Modified sequence Experiment N duplicates Sequence Length Missed cleavages Proteins Leading proteins Gene names Protein names Phospho (STY) All Phospho (STY) Probabilities Max Score Min PEP Intensity Reporter intensity corrected 1 Reporter intensity corrected 2 Reporter intensity corrected 3 Reporter intensity corrected 4 Reporter intensity corrected 5 Reporter intensity corrected 6 Reporter intensity corrected 7 Reporter intensity corrected 8 Reporter intensity corrected 9 Reporter intensity corrected 10 Phosphoproteome Fullproteome TMT Channel Normal 1 TMT Channel Normal 2 TMT Channel Normal 3 TMT Channel Normal 4 TMT Channel Normal 5 TMT Channel Normal 6 TMT Channel Normal 7 TMT Channel Normal 8 TMT Channel Normal 9 TMT Channel Normal 10 TMT Channel Ratio 1 TMT Channel Ratio 2 TMT Channel Ratio 3 TMT Channel Ratio 4 TMT Channel Ratio 5 TMT Channel Ratio 6 TMT Channel Ratio 7 TMT Channel Ratio 8 TMT Channel Ratio 9 TMT Channel Ratio 10 Curve signal Log EC50 Curve slope Curve top Curve bottom R2 Curve RMSE Log EC50 error Curve slope error Curve top error Curve bottom error EC50 pEC50 Curve effect size Regulation (ac)AAAAAAAAAAGAAGGRGS(ph)GPGR ddPTM_A459_Selumetinib_30min_R2 1 AAAAAAAAAAGAAGGRGSGPGR 22 1 Q86U42-2;Q86U42 Q86U42-2 PABPN1 Polyadenylate-binding protein 2 1 AAAAAAAAAAGAAGGRGS(1)GPGR 129.06 6.7935e-22 1861500.0 4225.7 4868.9 3464.7 3507.9 3520.7 4627.8 1719.4 2733.6 3248.3 3651.4 True False 3990.8525108173817 5242.328974018969 3241.784974080136 3030.117968534974 3078.398190542656 5265.237443014293 1799.3555069264648 2741.554323428158 3898.0507650852564 3545.974594523456 1.125459984112975 1.4783887572447447 0.9142155104796514 0.8545233158790276 0.8681388172653737 1.4848491726776991 0.5074360966109179 0.7731455063615863 1.0992889715300163 1.0 11.79196648460813 -5.278098447883944 24.272336666713024 0.9283172956735013 1.3019243580336237 0.2553691332720275 0.24836706265254446 644.5660816749629 939135.7310883254 0.06511030910331933 0.136191317325332 5.271103600618303e-06 5.278098447883944 0.3736070623601224 (ac)AAAAAAAGDS(ph)DSWDADAFSVEDPVRK ddPTM_A459_Selumetinib_30min_R1 6 AAAAAAAGDSDSWDADAFSVEDPVRK 26 1 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 AAAAAAAGDS(0.767)DS(0.233)WDADAFSVEDPVRK;AAAAAAAGDS(0.943)DS(0.057)WDADAFSVEDPVRK;AAAAAAAGDS(0.958)DS(0.042)WDADAFSVEDPVRK;AAAAAAAGDS(0.959)DS(0.041)WDADAFSVEDPVRK;AAAAAAAGDS(0.937)DS(0.063)WDADAFSVEDPVRK;AAAAAAAGDS(0.786)DS(0.214)WDADAFSVEDPVRK 99.414 1.4555e-11 48385800.0 10851.289999999999 11893.98 13167.320000000002 14826.8 12556.1 12184.53 11856.98 10998.329999999998 6662.61 9443.8 True False 11104.10394406524 10501.427292238706 11379.270266911495 12237.577713506087 11420.402971959498 12061.964690868077 10962.598452490642 10706.618560789271 11305.962552218805 10656.00372040187 1.0420514327341537 0.9854939588781099 1.0678740891507823 1.148420931017146 1.0717341389524966 1.1319407356976021 1.028772018116113 1.0047498895191351 1.0609946138224906 1.0 13.379378870769122 -10.435987848960194 6.612785748741587 0.9999999961553139 1.0607376819113865 0.12375333493571372 0.04805972716841846 3.038062126221789e-09 4.56621609699524e-10 0.05065948676319586 0.012286729553785394 3.6644782727601854e-11 10.435987848960194 0.060737685756072635 (ac)AAAAAAAGDS(ph)DSWDADAFSVEDPVRK ddPTM_A459_Selumetinib_30min_R2 1 AAAAAAAGDSDSWDADAFSVEDPVRK 26 1 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 AAAAAAAGDS(0.975)DS(0.025)WDADAFSVEDPVRK 83.245 3.9235e-09 2327500.0 5337.0 6889.5 6673.8 7580.9 8698.1 5205.6 6380.5 6342.4 4521.6 5958.7 True False 5040.390905703755 7417.902496765942 6244.414973884033 6548.368342218076 7605.366915999391 5922.624148268116 6677.205892720893 6360.855333959158 5426.046344059811 5786.6568484381105 0.8710367726512448 1.2818977677530894 1.0791058010584258 1.1316323939245785 1.3142937477020384 1.023496693063233 1.1538969853591978 1.0992280172403917 0.9376824107903284 1.0 12.498514378790121 -8.158705994525178 4.58226185217439 0.9700401030706252 1.130272085352405 0.20339132068693333 0.11868111016199684 0.3177000780036647 10.571876248967866 0.08256665393069221 0.028876494408275274 6.938953952353174e-09 8.158705994525178 0.16023198228177993 (ac)AAAAPDSRVS(ph)EEENLK ddPTM_A459_Selumetinib_30min_R2 1 AAAAPDSRVSEEENLK 16 1 Q9Y3B9 Q9Y3B9 RRP15 RRP15-like protein 1 AAAAPDS(0.006)RVS(0.994)EEENLK 76.332 0.0010784 0.0 15003.0 9411.0 16528.0 14340.0 18752.0 11140.0 13496.0 9894.6 8506.8 16241.0 True False 14169.193321767563 10132.793438865552 15464.606474325765 12386.86726212022 16396.20611499301 12674.43388114853 14123.59074181667 9923.391647860795 10208.39769985138 15772.080130814313 0.8983718827350395 0.6424513034947659 0.9805051931046287 0.7853667467691648 1.0395715707124342 0.8035993842299957 0.895480534252616 0.6291745645188052 0.6472448538926058 1.0 13.94508532480822 -10.5526834505967 4.917595603858725 1.0000017489724984 0.8159249236084131 0.1446537371675437 0.13591856555980772 4.694288175114493e-06 9.260800712109479e-07 0.1329336440665756 0.03224059824502573 2.8010221902474134e-11 10.5526834505967 -0.18407682536408532 (ac)AAAAPDSRVS(ph)EEENLKK ddPTM_A459_Selumetinib_30min_R1 1 AAAAPDSRVSEEENLKK 17 2 Q9Y3B9 Q9Y3B9 RRP15 RRP15-like protein 1 AAAAPDS(0.136)RVS(0.864)EEENLKK 63.682 0.0062106 14836000.0 2253.2 2886.2 3518.0 3542.0 3239.6 2683.2 2742.9 2785.0 1875.4 2170.6 True False 2305.69517603601 2548.2823622420233 3040.2749229907554 2923.4561915746185 2946.578751997834 2656.209444150673 2536.000844678542 2711.1327530450626 3182.4168262034163 2449.2176534344544 0.9414006847463361 1.0404474909237462 1.2413249262381731 1.1936285807327722 1.2030693751802528 1.0845134324529961 1.0354330253672615 1.106938270367002 1.2993605618270887 1.0 11.258105271539776 -5.009360592271498 4.775947136256654 1.1472113548024256 0.9577125863841941 0.35508366849514394 0.08801886792560973 0.1863900599960722 11.965991385120185 0.022841797777026343 0.08160142797805009 9.78677057901009e-06 5.009360592271498 -0.18949876841823154 (ac)AAADGDDSLYPIAVLIDELR ddPTM_A459_Selumetinib_30min_R1 1 AAADGDDSLYPIAVLIDELR 20 0 C9J9C1;P30153;M0QXG4;M0R0K6 C9J9C1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 65.472 0.0027382 5343700.0 0.0 138.02 65.564 131.05 0.0 0.0 0.0 0.0 0.0 0.0 False True 0.0 121.86055423624279 56.66076891727286 108.16457761317162 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)AAASVT(ph)PPGSLELLQPGFSK ddPTM_A459_Selumetinib_30min_R2 1 AAASVTPPGSLELLQPGFSK 20 0 B1AMX7;B1AMX8;Q12933-4;Q12933-3;Q12933;B1AMY1;Q12933-2 B1AMX7 TRAF2 TNF receptor-associated factor 2 1 AAAS(0.32)VT(0.68)PPGSLELLQPGFSK 118.52 0.0014787 1437000.0 8007.1 10596.0 8452.1 10410.0 10978.0 6334.5 6746.2 9359.0 6914.1 9831.5 True False 7562.097436960945 11408.679128490003 7908.301087950674 8992.140041748364 9598.845495434794 7207.019876134238 7059.911667341699 9386.233140534145 8297.113196095175 9547.63904969528 0.7920384712493184 1.1949214951579175 0.8282991268090588 0.9418181809078082 1.0053632573951512 0.7548483806961948 0.7394405706578341 0.983094678347074 0.8690225041928018 1.0 13.220928310753136 -6.737713688496044 24.99854033615182 0.8601095223658441 0.9584644630866396 0.09274998889777208 0.1278453102898984 509.0637138017562 536372.9459506136 0.04122408903585564 0.04120254799241216 1.8293058006285572e-07 6.737713688496044 0.09835494072079543 (ac)AADVSVTHRPPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AADVSVTHRPPLSPK 15 1 A0A087WZ13;Q8IY67-2;Q8IY67;Q8IY67-3 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 AADVS(0.001)VT(0.006)HRPPLS(0.993)PK 43.752 0.024659 370780000.0 7107.3 7699.8 8202.0 8782.9 8191.2 7131.2 7783.6 6909.0 2782.6 5435.2 True False 7272.886261601604 6798.303836460096 7088.213450361056 7249.131390451923 7450.307406273816 7059.466602611544 7196.476785387693 6725.750876405149 4721.868966936985 6132.86086333131 1.1858880257803606 1.1085044953665106 1.1557760086718825 1.1820146505841755 1.2148176148621905 1.1510886615446403 1.1734289992482623 1.0966742970835617 0.7699292503388235 1.0 12.582344505482707 -8.094163085696122 5.107889309416578 0.8889232141383251 1.164679985840424 0.7858117999985037 0.05804165790779622 0.09063592290466552 3.7008901058389925 0.03833041224254432 0.013969038274023612 8.05076063317468e-09 8.094163085696122 0.2757567717020989 (ac)AADVSVTHRPPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 AADVSVTHRPPLSPK 15 1 A0A087WZ13;Q8IY67-2;Q8IY67;Q8IY67-3 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 AADVS(0.007)VT(0.165)HRPPLS(0.828)PK;AADVSVT(0.004)HRPPLS(0.996)PK;AADVS(0.001)VT(0.038)HRPPLS(0.961)PK 48.71100000000001 0.021978 763826100.0 490282.0 426058.0 530155.0 653663.0 629236.0 429941.0 459573.0 481598.0 361737.0 544427.0 True False 463034.08919435 458735.27860760683 496045.4044891208 564632.9717684288 550185.7482387876 489161.47013419034 480944.05512662383 482999.37044715916 434094.5077762663 528707.9779187754 0.8757841919031629 0.8676534074885506 0.938221901704172 1.0679486509567528 1.0406231250842064 0.9252016057327954 0.9096591600902806 0.9135465902149894 0.8210477728840997 1.0 19.012111570811456 -10.28622952940935 13.070628174533017 1.0000046311638637 0.9335856958661405 0.07875948758370721 0.07136463538574954 0.0 0.0 0.07684222294753698 0.018636976571762134 5.173333433253221e-11 10.28622952940935 -0.06641893529772325 (ac)AAGGAAPETPAIS(ph)PSKR ddPTM_A459_Selumetinib_30min_R2 2 AAGGAAPETPAISPSKR 17 1 H0YNW5;H0YMM5 H0YNW5 DUT 1 AAGGAAPET(0.003)PAIS(0.739)PS(0.258)KR;AAGGAAPET(0.036)PAIS(0.798)PS(0.166)KR 71.143 0.0013521 20054200.0 77795.0 76598.0 86896.0 77903.0 78446.0 61547.0 71268.0 68130.0 52788.0 83390.0 True False 73471.46533805948 82472.82029861069 81305.20596521106 67292.47700982912 68590.91216386206 70024.54058196135 74582.10321486289 68328.24702047142 63347.075019955206 80982.31402675972 0.9072532221514643 1.0184053307165124 1.0039871908123623 0.8309527557781697 0.8469863202624334 0.8646893018989616 0.9209677953907077 0.8437428325139376 0.7822334516030606 1.0 16.305319247399993 -5.758393595994012 24.99864692197865 0.8643793140264574 0.9807342739734399 0.3859357308525678 0.06127664043687144 73.11651874601614 600099.6166261866 0.01631450071730508 0.026776483974906517 1.7442406515407904e-06 5.758393595994012 0.11635495994698253 (ac)AAGGDHGS(ph)PDSYR ddPTM_A459_Selumetinib_30min_R1 2 AAGGDHGSPDSYR 13 0 B4DEP1;A0A1W2PRX2;A0A096LP72;A0A096LNY4;A0A096LNY5;A0A1B0GTG9;A0A1B0GWF8;A0A1B0GWJ0;A0A1B0GTJ7;A0A0A6YY92;P30566-2;P30566 B4DEP1 ADSL Adenylosuccinate lyase 1 AAGGDHGS(0.993)PDS(0.007)YR;AAGGDHGS(0.973)PDS(0.027)YR 104.9 0.00010671 3573200.0 433.59 622.73 756.16 783.3100000000001 428.12 585.86 459.76 548.03 304.86 408.38 True False 443.69180338072636 549.8204821006773 653.4776252895651 646.5196130497783 389.39662159072486 579.9667803183193 425.0799330451003 533.4944641476794 517.3251539065658 460.7995509580588 0.9628737755022475 1.193187972856165 1.418138589612132 1.4030387219466354 0.8450455751988506 1.2586096907266884 0.922483392532191 1.157758211869953 1.1226685287148899 1.0 8.847995500671926 -6.248455463140432 24.996165980639702 1.0629273647075268 1.253074538260114 0.25416747320508737 0.16110513125101816 1175.8526449159115 2263708.519586954 0.048326229522367065 0.0619918441141312 5.643448118868081e-07 6.248455463140432 0.19014717355258726 (ac)AAGGDHGS(ph)PDSYR ddPTM_A459_Selumetinib_30min_R2 2 AAGGDHGSPDSYR 13 0 B4DEP1;A0A1W2PRX2;A0A096LP72;A0A096LNY4;A0A096LNY5;A0A1B0GTG9;A0A1B0GWF8;A0A1B0GWJ0;A0A1B0GTJ7;A0A0A6YY92;P30566-2;P30566 B4DEP1 ADSL Adenylosuccinate lyase 1 AAGGDHGS(0.981)PDS(0.019)YR;AAGGDHGS(0.775)PDS(0.225)YR 89.26 0.00032444 7051500.0 1295.1 0.0 1201.4 837.84 812.16 952.13 0.0 0.0 0.0 0.0 True False 1223.1235266960723 0.0 1124.1032319854164 723.7247466453841 710.1291999974782 1083.277264924412 0.0 0.0 0.0 0.0 0.0 (ac)AALGHLAGEAAAAPGPGT(ph)PCASR ddPTM_A459_Selumetinib_30min_R1 4 AALGHLAGEAAAAPGPGTPCASR 23 0 A0A3B3IRR6;A0A3B3IT54;A0A3B3ITA3;Q9H7E9;Q9H7E9-2 A0A3B3IRR6 C8orf33 UPF0488 protein C8orf33 1 AALGHLAGEAAAAPGPGT(0.998)PCAS(0.002)R;AALGHLAGEAAAAPGPGT(0.996)PCAS(0.004)R;AALGHLAGEAAAAPGPGT(0.995)PCAS(0.005)R;AALGHLAGEAAAAPGPGT(0.999)PCAS(0.001)R 165.41 5.2437e-44 83945000.0 119.53 61.756 406.034 285.12 146.469 308.15299999999996 0.0 0.0 135.32 0.0 True False 122.31481643510745 54.525578810414494 350.89681298511334 235.32914436526124 133.22090481120225 305.0532606005376 0.0 0.0 229.6281566182395 0.0 0.0 (ac)AALGHLAGEAAAAPGPGT(ph)PCASR ddPTM_A459_Selumetinib_30min_R2 3 AALGHLAGEAAAAPGPGTPCASR 23 0 A0A3B3IRR6;A0A3B3IT54;A0A3B3ITA3;Q9H7E9;Q9H7E9-2 A0A3B3IRR6 C8orf33 UPF0488 protein C8orf33 1 AALGHLAGEAAAAPGPGT(0.999)PCAS(0.001)R;AALGHLAGEAAAAPGPGT(0.997)PCAS(0.003)R;AALGHLAGEAAAAPGPGT(0.996)PCAS(0.004)R 156.36 7.566699999999997e-53 49275700.0 1320.0 1180.7 1134.1 581.58 1698.4 757.03 883.94 1866.02 662.2 1641.2 True False 1246.6396843786695 1271.2558934511285 1061.1332407147177 502.36780071854116 1485.031808111355 861.3040108658776 925.0449614938813 1871.44980926376 794.6585034139258 1593.8142916502975 0.782173739380797 0.7976185808541223 0.6657822346516789 0.31519845401710506 0.9317470773672729 0.5404042462023915 0.5803969548648316 1.174195650690262 0.49858914402825777 1.0 10.638267823574306 -7.677291360636146 24.998902937830092 0.877634786041444 0.6573344826321732 0.18533699672618098 0.2222361582322681 42.12238958859321 12508.092474512694 0.10029202136367908 0.05790359337668991 2.1023675246282333e-08 7.677291360636146 -0.22030030340927076 (ac)AALHT(ph)TPDSPAAQLER ddPTM_A459_Selumetinib_30min_R1 2 AALHTTPDSPAAQLER 16 0 A6NFI3 A6NFI3 ZNF316 Zinc finger protein 316 1 AALHT(0.688)T(0.014)PDS(0.299)PAAQLER;AALHT(0.934)T(0.016)PDS(0.05)PAAQLER 132.65 2.5817e-11 30982000.0 410.92 171.69 97.149 327.0 395.65 288.82 292.15 256.12800000000004 0.0 176.75 True False 420.49363648886793 151.5884549834844 83.95669940125894 269.8955885502261 359.86352735768094 285.9147330275783 270.11289028868566 249.33465341900398 0.0 199.4375841907951 2.108397161924084 0.7600796790562051 0.42096729030241586 1.353283482876659 1.8043917289602338 1.4336050759321948 1.354373055533394 1.2501888970961164 0.0 1.0 7.639793502300268 -8.175487907167073 8.85885561955972 0.5025115163258337 1.2875830958650045 0.29521900717749805 0.5001141266284849 0.44020926139079003 41.768513548326624 0.3492638451947729 0.13136742226346973 6.675934896972399e-09 8.175487907167073 0.7850715795391708 (ac)AALHT(ph)TPDSPAAQLER ddPTM_A459_Selumetinib_30min_R2 1 AALHTTPDSPAAQLER 16 0 A6NFI3 A6NFI3 ZNF316 Zinc finger protein 316 1 AALHT(0.611)T(0.278)PDS(0.111)PAAQLER 130.47 1.9364e-39 13769000.0 865.0 1446.2 552.33 538.0 971.63 707.85 747.72 0.0 0.0 1135.9 True False 816.9267628693553 1557.1188897340746 516.7936891314345 464.7234718982338 849.5651529175907 805.3499122774674 782.4904615790721 0.0 0.0 1103.1036155773645 0.7405711950656384 1.411579898520302 0.46849061306080897 0.4212872347943466 0.7701589777429279 0.7300763961832789 0.7093535462391867 0.0 0.0 1.0 10.107352595680899 -7.6760449907346855 7.64917555262739 0.2518903280444681 0.7547888428908253 0.20851000371034378 0.3623823229897525 0.30500113200721557 23.375530412512187 0.17264185374386207 0.09888758631368103 2.1084097179250465e-08 7.6760449907346855 0.5028985148463572 (ac)AALHTTPDS(ph)PAAQLER ddPTM_A459_Selumetinib_30min_R2 3 AALHTTPDSPAAQLER 16 0 A6NFI3 A6NFI3 ZNF316 Zinc finger protein 316 1 AALHTT(0.007)PDS(0.992)PAAQLER;AALHT(0.01)T(0.005)PDS(0.985)PAAQLER;AALHT(0.116)T(0.053)PDS(0.831)PAAQLER 133.9 6.9877e-40 92149000.0 16405.0 17529.5 34957.9 21776.7 18960.7 14451.17 24331.5 17473.0 15244.0 21725.9 True False 15493.275774418236 18873.956283773652 32708.74677328367 18810.675893097177 16578.687355191338 16441.68749283997 25462.962961952573 17523.843537189132 18293.225952947578 21098.61681633266 0.7343266105683635 0.894558939482854 1.55027919877494 0.8915596722215287 0.7857712901045534 0.7792779799722364 1.2068546096463266 0.8305683585676452 0.8670343706506202 1.0 14.36486080134319 (ac)AAPEEHDS(ph)PTEASQPIVEEEETK ddPTM_A459_Selumetinib_30min_R1 2 AAPEEHDSPTEASQPIVEEEETK 23 0 F5H1N9;Q9H0S4-2;Q9H0S4 F5H1N9 DDX47 Probable ATP-dependent RNA helicase DDX47 1 AAPEEHDS(0.365)PT(0.27)EAS(0.365)QPIVEEEETK;AAPEEHDS(0.688)PT(0.156)EAS(0.156)QPIVEEEETK 59.163 2.0652e-05 21191800.0 3177.1 3349.1 4198.9 4026.1000000000004 3152.7 3213.5 3406.7 3008.8999999999996 1836.89 2892.8 True False 3251.1202484395535 2956.9858150456507 3628.7124429067326 3323.01721425708 2867.5388416543938 3181.1751076245496 3149.7298762500927 2929.0941977153643 3117.0681688625314 3264.1190582581735 0.9960176667619605 0.9059062375695274 1.1116973303183115 1.0180441200053334 0.8785031398899382 0.9745891773084143 0.9649555730148146 0.8973613233576143 0.9549492874582484 1.0 11.672477965018695 -6.22111465593145 24.983982501350873 0.9423990501669522 1.0080428498325893 0.22479861339761298 0.05705456735711996 791.0794035110908 490128.74123529735 0.016994037837716712 0.021938991461224196 6.010150455361795e-07 6.22111465593145 0.06564379966563705 (ac)AASAAAAS(ph)AAAASAASGSPGPGEGSAGGEKR ddPTM_A459_Selumetinib_30min_R1 1 AASAAAASAAAASAASGSPGPGEGSAGGEKR 31 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AAS(0.003)AAAAS(0.856)AAAAS(0.076)AAS(0.015)GS(0.05)PGPGEGSAGGEKR 71.524 1.8645e-11 4845000.0 800.11 838.71 828.0 1190.0 832.29 838.48 791.02 631.48 415.48 501.37 True False 818.7510062569555 740.5134432942991 715.5621478784378 982.188839066572 757.009516452734 830.0456524789271 731.3527245461444 614.7310990638767 705.0392145414288 565.725723257363 1.4472578717876063 1.3089619454292 1.2648570119073592 1.7361572908710556 1.3381210811733784 1.4672227518657803 1.2927690831081997 1.0866239129526376 1.2462562431878115 1.0 9.143958960848538 -7.5552149517524505 3.320854741765619 1.1249795124607738 1.4236200821968963 0.5265698598849871 0.13369981577720214 0.20874013799331573 4.791223965901523 0.06865741405282438 0.03828963942208226 2.7847425339233914e-08 7.5552149517524505 0.2986405697361225 (ac)AASAAAASAAAAS(ph)AASGSPGPGEGSAGGEKR ddPTM_A459_Selumetinib_30min_R1 1 AASAAAASAAAASAASGSPGPGEGSAGGEKR 31 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AASAAAAS(0.042)AAAAS(0.544)AAS(0.042)GS(0.372)PGPGEGSAGGEKR 82.62700000000002 4.7421e-16 4436300.0 593.74 632.87 695.32 775.29 662.47 674.98 714.94 608.37 496.92 416.81 True False 607.5729867830727 558.7732861867194 600.8993631193672 639.900155495733 602.5497054685784 668.190314032805 661.0115001985042 592.2340513357367 843.2369463991694 470.3116235732124 1.2918519473684518 1.1880915932747222 1.277662156325223 1.3605875836834833 1.2811711964307444 1.4207395278819623 1.4054755763347746 1.25923753879654 1.7929323965940733 1.0 8.87747317807142 -6.006474463572116 1.0294730633547544 1.3902163116767794 1.2350031603035088 0.05867710328004272 0.18656128903922636 1.4383101472141582 3.100914695217457 0.0734203317921208 0.15354014583110404 9.852025708132657e-07 6.006474463572116 -0.15521315137327063 (ac)AASAAAASAAAAS(ph)AASGSPGPGEGSAGGEKR ddPTM_A459_Selumetinib_30min_R2 1 AASAAAASAAAASAASGSPGPGEGSAGGEKR 31 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AASAAAAS(0.036)AAAAS(0.371)AAS(0.294)GS(0.294)PGPGEGS(0.005)AGGEKR 51.104 1.4259e-08 31138000.0 31946.0 28977.0 36698.0 39065.0 31027.0 24057.0 19314.0 28730.0 28130.0 32885.0 True False 30170.56920997042 31199.44272425961 34336.8906337613 33744.279609116216 27129.11087510068 27370.633382297165 20212.13926996495 28813.599543492463 33756.78601787033 31935.52460450889 0.9447337904607561 0.9769510008254145 1.075194193895076 1.0566377107314515 0.8494963277124433 0.8570591440490312 0.6329045638132794 0.9022428753033338 1.0570293250515226 1.0 14.962874529390922 -6.267720739685389 24.578778149606514 0.864420158008633 1.0151925217112754 0.23959728552710513 0.11069411687191362 545.134959153364 2133093.419392454 0.03587451734803558 0.041689142231393646 5.398576505406825e-07 6.267720739685389 0.15077236370264235 (ac)AASAAAASAAAASAAS(ph)GSPGPGEGSAGGEKR ddPTM_A459_Selumetinib_30min_R2 2 AASAAAASAAAASAASGSPGPGEGSAGGEKR 31 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AASAAAASAAAAS(0.004)AAS(0.617)GS(0.373)PGPGEGS(0.006)AGGEKR;AASAAAAS(0.027)AAAAS(0.189)AAS(0.629)GS(0.134)PGPGEGS(0.021)AGGEKR 81.455 2.7053e-16 258460000.0 78579.0 86207.0 91769.0 102997.0 96068.0 64434.0 69167.0 71110.0 54780.0 101570.0 True False 74211.89375666025 92818.79970080598 85864.68245053256 88968.63092026471 83999.07898118313 73309.19862638463 72383.40255181043 71316.91832710571 65737.53068108563 98637.41018944704 0.7523706635659417 0.9410101048125088 0.8705082816511236 0.901976549763299 0.8515945301062859 0.7432190128023839 0.7338331614018243 0.7230209936588109 0.666456373447229 1.0 16.589847300580843 -6.697801178534538 4.851907054926612 0.7533917304948194 0.8722698512070813 0.16881551152280294 0.09481679925680073 0.2751257573976857 12.675270390951313 0.03027592913979873 0.0297307899871859 2.005389891443906e-07 6.697801178534538 0.11887812071226189 (ac)AASAAAASAAAASAASGS(ph)PGPGEGSAGGEK ddPTM_A459_Selumetinib_30min_R2 1 AASAAAASAAAASAASGSPGPGEGSAGGEK 30 0 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AASAAAASAAAASAAS(0.004)GS(0.996)PGPGEGSAGGEK 97.158 2.1918000000000004e-19 4744100.0 20748.0 15761.0 18054.0 18643.0 19966.0 16498.0 19229.0 19199.0 15352.0 15536.0 True False 19594.909220824717 16969.818020397423 16892.425295708945 16103.791239031192 17457.692581695304 18770.449746067203 20123.186601540638 19254.865911434452 18422.82897071972 15087.435312624295 1.2987568009275128 1.124764923180685 1.1196353088304105 1.0673643933078851 1.1571014039137397 1.244111365326695 1.3337711933520415 1.276218622480064 1.2210709500311534 1.0 13.881059964988324 -6.7278057442468775 5.84954382561673 1.2398754901101958 1.1444953511732525 0.05765460277227796 0.09943699524721217 0.32687859192324953 30.289488530167606 0.0328163504093756 0.0319952325346699 1.871519065691576e-07 6.7278057442468775 -0.0953801389369433 (ac)AASAAAASAAAASAASGS(ph)PGPGEGSAGGEKR ddPTM_A459_Selumetinib_30min_R1 6 AASAAAASAAAASAASGSPGPGEGSAGGEKR 31 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AASAAAAS(0.017)AAAAS(0.104)AAS(0.224)GS(0.654)PGPGEGS(0.001)AGGEKR;AAS(0.002)AAAAS(0.021)AAAAS(0.059)AAS(0.067)GS(0.844)PGPGEGS(0.007)AGGEKR;AASAAAASAAAAS(0.072)AAS(0.296)GS(0.63)PGPGEGS(0.002)AGGEKR;AAS(0.001)AAAAS(0.001)AAAAS(0.006)AAS(0.021)GS(0.954)PGPGEGS(0.016)AGGEKR;AASAAAAS(0.251)AAAAS(0.322)AAS(0.057)GS(0.369)PGPGEGS(0.001)AGGEKR;AASAAAASAAAAS(0.001)AAS(0.03)GS(0.965)PGPGEGS(0.004)AGGEKR 123.02 2.8733e-28 564683000.0 9003.69 9696.619999999999 12076.61 12371.779999999999 10848.519999999999 9923.58 9262.11 9607.199999999999 5850.540000000001 7988.54 True False 9213.458458869009 8561.335222563666 10436.672694070323 10211.280870073131 9867.273281461767 9823.757795089725 8563.461585732459 9352.385847416348 9927.939073464937 9013.946923969075 1.0221336487315462 0.9497876229776919 1.1578360491915105 1.132831262065701 1.0946673377034875 1.0898397647502531 0.9500235199922549 1.0375461411412714 1.101397551727918 1.0 13.13794323984604 (ac)AASAAAASAAAASAASGS(ph)PGPGEGSAGGEKR ddPTM_A459_Selumetinib_30min_R2 3 AASAAAASAAAASAASGSPGPGEGSAGGEKR 31 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 AASAAAASAAAAS(0.009)AAS(0.047)GS(0.94)PGPGEGS(0.004)AGGEKR;AASAAAAS(0.02)AAAAS(0.052)AAS(0.31)GS(0.587)PGPGEGS(0.031)AGGEKR;AAS(0.001)AAAAS(0.012)AAAAS(0.033)AAS(0.323)GS(0.63)PGPGEGS(0.001)AGGEKR 76.446 6.7122e-12 254904700.0 106910.0 112546.0 118062.1 122067.0 122515.0 84502.8 84155.7 82516.9 74577.9 100550.5 True False 100968.37019463914 121177.91630757244 110466.11302229503 105441.26402267977 107123.57040200343 96142.29365995685 88069.106801356 82757.01051759176 89495.56388063045 97647.34580342642 1.0340103907985196 1.2409750138167128 1.13127614594537 1.0798170001972534 1.0970453883882678 0.9845868606966606 0.9019098888632124 0.847509062706012 0.916518141320438 1.0 16.57529320964948 -6.841286107730859 1.76543547411362 0.902029810491524 1.1317030824571022 0.7090193850010912 0.06075923315196724 0.17696819061356697 1.1363683674164733 0.025887348334137077 0.022259523771143857 1.4411656169785333e-07 6.841286107730859 0.22967327196557819 (ac)AASEAAVVSS(ph)PSLK ddPTM_A459_Selumetinib_30min_R2 1 AASEAAVVSSPSLK 14 0 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 1 AASEAAVVS(0.147)S(0.766)PS(0.087)LK 95.264 0.00040888 1972700.0 12564.0 17323.0 11418.0 16205.0 17321.0 14273.0 13274.0 13483.0 10228.0 16199.0 True False 11865.743177676974 18651.6183977758 10683.378310978433 13997.85104481577 15144.981128295321 16238.976192606193 13891.267301932003 13522.233297769193 12273.885794197582 15731.292779943435 0.7542764185792262 1.1856379929280592 0.6791163612820921 0.8898093272195842 0.962729595091153 1.0322721990979677 0.8830340580554595 0.8595754644532028 0.780221051498459 1.0 13.941349614230313 -10.725996214505194 4.884761171212251 1.0000061313386674 0.8991821295960782 0.0503784904884923 0.1375877362951307 1.8592097182696102e-05 3.0331139330122437e-06 0.12803916627110526 0.031050083564112315 1.879333197796695e-11 10.725996214505194 -0.10082400174258921 (ac)AAT(ph)DLERFSNAEPEPR ddPTM_A459_Selumetinib_30min_R2 1 AATDLERFSNAEPEPR 16 1 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-2;Q92599-4;Q92599 A0A087X142 SEPT8 Septin-8 1 AAT(0.983)DLERFS(0.017)NAEPEPR 86.11399999999998 5.6878e-05 4494300.0 2255.9 3695.8 6522.9 4163.5 4664.5 2964.9 4203.2 3248.9 4429.9 3633.3 True False 2130.526109083212 3979.2559761299885 6103.223715596535 3596.4241175618918 4078.5038088409183 3373.288062317533 4398.657128482792 3258.3537611156517 5316.003781747738 3528.3971885529018 0.6038226410550459 1.1277800552159483 1.7297439572271183 1.019279838797539 1.1559083603378653 0.9560397772851124 1.2466445508893542 0.9234656947598343 1.5066341734412234 1.0 11.784797257604593 -8.24514518405126 24.953882092991364 1.2533172295068744 1.117448390510297 0.04026178960739202 0.2930278253572018 3004.2963981948787 4600972.371234191 0.19860952678155147 0.0745754869174775 5.686627958698545e-09 8.24514518405126 -0.13586883899657742 (ac)ACGLVAS(ph)NLNLKPGECLR ddPTM_A459_Selumetinib_30min_R2 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 1 ACGLVAS(1)NLNLKPGECLR 86.772 0.00034729 3375200.0 5348.4 4816.9 7897.1 6300.5 8607.4 5438.6 4735.6 5425.9 5180.9 6414.1 True False 5051.157339341573 5186.340741225323 7389.009183712361 5442.361031031272 7526.0614608676815 6187.717783304706 4955.814783413379 5441.688470693897 6217.224766440971 6228.908267166809 0.8109217735580924 0.832624357074423 1.1862446622726102 0.8737263092665042 1.2082472783454357 0.9933872065383877 0.7956153102359795 0.8736183352350162 0.9981243100356088 1.0 12.60476361074222 -10.405861979655482 17.919487362092955 0.9999999946486902 0.9553232968315899 0.009929178718775855 0.13975809287775667 0.0 0.0 0.13856815003837936 0.03360771287968671 3.9276973919930536e-11 10.405861979655482 -0.044676697817100264 (ac)ACRPRS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 ACRPRSPPR 9 2 E7EUV9;F8W8D3;Q14493;Q14493-2 E7EUV9 SLBP Histone RNA hairpin-binding protein 1 ACRPRS(1)PPR 60.019 0.033098 1982200.0 0.0 0.0 0.0 582.16 433.8 0.0 0.0 0.0 460.34 0.0 True False 0.0 0.0 0.0 502.86880371798475 379.302165778795 0.0 0.0 0.0 552.420862974278 0.0 0.0 (ac)ACS(ph)PDAVVSPSSAFLR ddPTM_A459_Selumetinib_30min_R1 1 ACSPDAVVSPSSAFLR 16 0 Q93100-4;Q93100-2;I3L3F2;H3BV13;H3BQ89 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 ACS(1)PDAVVSPSSAFLR 118.77 0.00036737 13358000.0 0.0 198.09 158.95 160.54 58.034 153.99 64.854 0.0 0.0 122.6 True False 0.0 174.8975307104574 137.36546304985237 132.50470270903145 52.784834946734875 152.44100041173314 59.962010565745025 0.0 0.0 138.33690422512854 0.0 1.2642868632207525 0.992977714943691 0.9578405954017462 0.38156727044312916 1.10195469000558 0.4334491284275327 0.0 0.0 1.0 7.112042266294288 -7.482298726016236 7.338050122598772 0.242743361862478 0.802368395784379 0.18061089826286614 0.4331200218872738 0.3235569643904373 50.42990350424958 0.17811311873622626 0.1172433972867263 3.2938307070582947e-08 7.482298726016236 0.559625033921901 (ac)ACS(ph)PDAVVSPSSAFLR ddPTM_A459_Selumetinib_30min_R2 2 ACSPDAVVSPSSAFLR 16 0 Q93100-4;Q93100-2;I3L3F2;H3BV13;H3BQ89 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 ACS(1)PDAVVSPSSAFLR;ACS(1)PDAVVSPSSAFLR 95.618 0.00071513 7031800.0 2470.91 1347.6 2255.51 1950.49 979.66 3008.1 3132.71 1218.3 0.0 0.0 True False 2333.586714036438 1450.9565867830447 2110.3929422136066 1684.8298972170762 856.586352528479 3422.4384701869744 3278.3872223471 1221.8450512995778 0.0 0.0 0.0 (ac)ADANKAEVPGAT(ph)GGDSPHLQPAEPPGEPR ddPTM_A459_Selumetinib_30min_R1 3 ADANKAEVPGATGGDSPHLQPAEPPGEPR 29 1 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;A0A087WWC8;Q9P2K5-4 A0A0A0MQW0 MYEF2 Myelin expression factor 2 1 ADANKAEVPGAT(0.943)GGDS(0.057)PHLQPAEPPGEPR;ADANKAEVPGAT(0.913)GGDS(0.087)PHLQPAEPPGEPR;ADANKAEVPGAT(0.781)GGDS(0.219)PHLQPAEPPGEPR 90.744 2.8711e-14 231820000.0 4925.4 4550.400000000001 9183.3 10141.900000000001 7971.0 6716.5 5162.3 5137.9 3207.28 3694.89 True False 5040.1522368399455 4017.6370525764314 7936.258300256113 8370.807552041402 7250.02445739435 6648.938108094069 4772.903554808425 5001.62620174874 5442.519909537004 4169.165122776389 1.208911637801368 0.9636550566509945 1.9035605610581068 2.0077898825141753 1.7389631362372888 1.5947888635474134 1.1448103911101477 1.1996709303799382 1.3054220087864128 1.0 12.025542796912275 -7.259271964912326 24.089650274641585 1.1791150597522082 1.5848625662672136 0.3096966192936408 0.2968424389281192 170.9514129325755 1900053.624396188 0.13295366272128417 0.09784743321907818 5.504628762920432e-08 7.259271964912326 0.40574750651500535 (ac)ADANKAEVPGAT(ph)GGDSPHLQPAEPPGEPR ddPTM_A459_Selumetinib_30min_R2 3 ADANKAEVPGATGGDSPHLQPAEPPGEPR 29 1 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;A0A087WWC8;Q9P2K5-4 A0A0A0MQW0 MYEF2 Myelin expression factor 2 1 ADANKAEVPGAT(0.863)GGDS(0.137)PHLQPAEPPGEPR;ADANKAEVPGAT(0.765)GGDS(0.235)PHLQPAEPPGEPR;ADANKAEVPGAT(0.765)GGDS(0.235)PHLQPAEPPGEPR 57.71100000000001 7.4612e-14 127342000.0 94808.0 137479.0 129491.0 139123.0 118153.0 64820.0 50188.0 49267.0 29554.200000000004 124929.0 True False 89538.95090649459 148023.1972353416 121159.6900391404 120174.20739943875 103309.5638387782 73748.36662262552 52521.84144563532 49410.35881340911 35465.86581334318 121321.97516547657 0.738027474283767 1.2200856195544625 0.9986623600043206 0.9905394899442386 0.8515321622308701 0.6078731122044193 0.43291284512965095 0.4072663567009692 0.2923284571073762 1.0 16.8884813652979 -6.717536713208582 2.049928788845722 0.48371183583005173 1.004640078583926 0.4995457287543906 0.2075966326740067 0.23011871257087946 1.9891920631482285 0.07752658265463722 0.07342049698640132 1.9162990609973414e-07 6.717536713208582 0.5209282427538743 (ac)ADANKAEVPGATGGDS(ph)PHLQPAEPPGEPR ddPTM_A459_Selumetinib_30min_R1 1 ADANKAEVPGATGGDSPHLQPAEPPGEPR 29 1 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;A0A087WWC8;Q9P2K5-4 A0A0A0MQW0 MYEF2 Myelin expression factor 2 1 ADANKAEVPGAT(0.091)GGDS(0.909)PHLQPAEPPGEPR 78.583 1.6602999999999993e-11 41930000.0 1169.3 1135.5 1786.4 2001.7 1373.2 1063.1 1111.0 769.43 661.77 867.39 True False 1196.5424149382686 1002.555132120372 1543.8166919928046 1652.140671562653 1248.994302458151 1052.406179217569 1027.1963755287684 749.0222169391247 1122.9753562315432 978.7279555940803 1.2225485213733132 1.0243450454133896 1.5773705892110947 1.6880489232166833 1.2761404181001665 1.0752795740658767 1.049521850947098 0.7653017497435987 1.1473825283246413 1.0 9.934764097963068 -6.790375990179267 2.8523391234788478 0.9807138368267517 1.3772594107718275 0.46326346963116904 0.19169836063819798 0.25710154148480874 4.286622975864429 0.07833920423187567 0.07152307322519948 1.6204066238854035e-07 6.790375990179267 0.3965455739450757 (ac)ADANKAEVPGATGGDS(ph)PHLQPAEPPGEPR ddPTM_A459_Selumetinib_30min_R2 1 ADANKAEVPGATGGDSPHLQPAEPPGEPR 29 1 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;A0A087WWC8;Q9P2K5-4 A0A0A0MQW0 MYEF2 Myelin expression factor 2 1 ADANKAEVPGAT(0.265)GGDS(0.735)PHLQPAEPPGEPR 67.72800000000001 6.4571e-14 48734000.0 77823.0 106340.0 115000.0 106080.0 100520.0 59567.0 42198.0 38115.0 32979.0 89585.0 True False 73497.90921015243 114495.93606300723 107601.02520253298 91631.72100179293 87891.77893979829 67771.81355461171 44160.29061375067 38225.90833972209 39575.72151025048 86998.44828021692 0.8448186222059956 1.3160687153203297 1.2368154527993 1.0532569581776046 1.0102683516458133 0.7790002568358766 0.5075986007418541 0.43938609360707986 0.45490146425117134 1.0 16.40870204857518 -6.832658812595582 1.8998243960338372 0.5532902072674732 1.1331839143088662 0.5985843653364769 0.19021345929597738 0.20524007488467297 1.5239796260863072 0.07770840885430931 0.0676492571110129 1.4700807386900907e-07 6.832658812595582 0.579893707041393 (ac)ADEAALALQPGGS(ph)PSAAGADR ddPTM_A459_Selumetinib_30min_R1 3 ADEAALALQPGGSPSAAGADR 21 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 ADEAALALQPGGS(0.978)PS(0.022)AAGADR;ADEAALALQPGGS(0.907)PS(0.093)AAGADR;ADEAALALQPGGS(0.888)PS(0.112)AAGADR 123.61 1.3065999999999999e-16 41141600.0 182.599 282.25 278.616 372.687 195.615 196.76 287.77 201.39 67.133 143.22 True False 186.85320142419636 249.20403878553492 240.7814775281389 307.60421165143157 177.92165778863324 194.78077304378598 266.0632772150438 196.04848299308634 113.91979779967684 161.60368208093723 1.1562434656075051 1.542069064123948 1.4899504418936844 1.9034480383768222 1.100975271711466 1.2052991029389566 1.6463936575516223 1.213143663984697 0.7049331817985527 1.0 7.3363162595190765 -8.048762446885409 4.8242635937705804 0.8682561300745331 1.4380938534272383 0.4846671419054023 0.2380428966501477 0.18173775863232725 9.279964848765694 0.16718764407673575 0.06269375187905878 8.937942432194598e-09 8.048762446885409 0.5698377233527052 (ac)ADEAALALQPGGS(ph)PSAAGADR ddPTM_A459_Selumetinib_30min_R2 2 ADEAALALQPGGSPSAAGADR 21 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 ADEAALALQPGGS(0.86)PS(0.14)AAGADR;ADEAALALQPGGS(0.653)PS(0.347)AAGADR 127.37 1.1617e-16 68231000.0 1910.0 1162.2 3637.8 1808.8 1768.3 2730.5 1425.4 1351.0 0.0 1118.8 True False 1803.849846335802 1251.3370029380033 3403.7479085371656 1562.4383196459585 1546.1503451974247 3106.6015899888753 1491.6839243765173 1354.9311863299106 0.0 1086.4973370085015 1.6602432283013386 1.1517165853193545 3.1327715150309037 1.438050758548461 1.423059488994704 2.859281366066125 1.3729292043030983 1.247063513345094 0.0 1.0 10.085468923157963 -7.852249178999423 2.362563888546657 0.5364757804807504 1.9135171729727027 0.41219944323844226 0.6524599482678325 0.29209588422901744 3.1843882006698827 0.45619183501816973 0.18066165977971171 1.405241027526384e-08 7.852249178999423 1.3770413924919525 (ac)ADEAALALQPGGSPS(ph)AAGADR ddPTM_A459_Selumetinib_30min_R1 1 ADEAALALQPGGSPSAAGADR 21 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 ADEAALALQPGGS(0.271)PS(0.729)AAGADR 94.313 3.2483e-08 27612000.0 511.62 689.0 599.43 601.22 556.36 670.56 718.88 607.88 200.71 726.91 True False 523.5397505607771 608.3315596925901 518.0306984332998 496.2282132971464 506.03733623333613 663.814775219766 664.6543028263914 591.7570477274803 340.5902107215995 820.215979203003 0.6382949903871615 0.741672407167318 0.6315784032111468 0.6049970079579858 0.6169562030784238 0.809317048254521 0.8103405928182847 0.7214649101356031 0.4152445445558719 1.0 9.679860039868007 -6.744545413001321 24.894824221565763 0.7375566932580124 0.6488191536622161 0.1189126513050861 0.1397973459978966 625.2560257959472 921370.6676966635 0.04592767275661251 0.045811723671999656 1.800754824526836e-07 6.744545413001321 -0.08873753959579633 (ac)ADEAALALQPGGSPS(ph)AAGADREAASSPAGEPLR ddPTM_A459_Selumetinib_30min_R1 2 ADEAALALQPGGSPSAAGADREAASSPAGEPLR 33 1 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 ADEAALALQPGGS(0.263)PS(0.737)AAGADREAASSPAGEPLR;ADEAALALQPGGS(0.068)PS(0.931)AAGADREAASSPAGEPLR 79.82600000000002 1.0214e-18 23940000.0 70.42699999999998 0.0 124.32 170.06 94.872 133.33 109.31 154.31 131.81 0.0 True False 72.0678120729132 0.0 107.43802684087856 140.36221342156404 86.29084435101201 131.988821253954 101.0646586940141 150.21719753047896 223.67194297849647 0.0 0.0 (ac)ADEAALALQPGGSPS(ph)AAGADREAASSPAGEPLRK ddPTM_A459_Selumetinib_30min_R1 1 ADEAALALQPGGSPSAAGADREAASSPAGEPLRK 34 2 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 ADEAALALQPGGS(0.28)PS(0.72)AAGADREAASSPAGEPLRK 52.96 2.6919e-11 5791800.0 362.98 171.97 896.02 939.39 468.2 415.29 477.46 390.25 274.56 272.44 True False 371.4367277638694 151.835672453316 774.345405485553 775.3431710342412 425.85139266742385 411.1125596531504 441.4448077947485 379.89930228934867 465.90826693100706 307.4103277903264 1.2082766718794598 0.4939185795894199 2.518931003559862 2.522176716076615 1.3852865508080192 1.3373414049171295 1.4360116361992958 1.2358052672467934 1.5155908075046407 1.0 8.26402182455486 -6.492320608653833 24.990017228201467 1.3315937109384586 1.696888816374568 0.09214066214916672 0.5662732184189958 2016.341610669672 1648937.680146969 0.19343812821343145 0.2190524352954799 3.218691783330188e-07 6.492320608653833 0.3652951054361093 (ac)ADEELEALRR ddPTM_A459_Selumetinib_30min_R2 1 ADEELEALRR 10 1 O14737;Q3HM38;X6R2P6;K7ESJ4;O14737-2 O14737 PDCD5 Programmed cell death protein 5 0 71.223 0.013454 18624000.0 6109.5 7120.0 4546.2 7667.7 7950.5 0.0 6113.3 5683.9 2710.1 6041.1 False True 5769.958448266272 7666.081105591626 4253.7024415283 6623.346032479718 6951.687111628192 0.0 6397.580563274138 5700.439207979702 3252.1957265208107 5866.677746337194 0.9835137871461737 1.3067159024335149 0.7250615468327131 1.1289773051903087 1.1849444288922149 0.0 1.0904946274351626 0.9716639390221695 0.554350497357945 1.0 12.518328032333587 (ac)ADELS(ph)EK ddPTM_A459_Selumetinib_30min_R1 1 ADELSEK 7 0 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin;Caveolin-1 1 ADELS(1)EK 72.87899999999998 0.010271 17503000.0 4588.3 4950.9 6254.1 4260.9 5444.5 5039.6 4695.0 6655.8 3693.7 6422.2 True False 4695.19846272236 4371.246326389031 5404.827571312247 3516.8138019989547 4952.045936304544 4988.906199590688 4340.852370033817 6479.26656291466 6267.939122825829 7246.551927525451 0.6479217301801181 0.6032174156905162 0.7458481806750655 0.485308576709513 0.683365824992517 0.688452418403396 0.5990231510720891 0.894117178447819 0.8649546964560567 1.0 12.82307897629096 -7.768743874836159 23.720393760837432 0.9096522206078645 0.6371386180848526 0.7615479432530825 0.0726373415468887 42.85915649809009 139174.34723598463 0.037106339675912405 0.018440826174485767 1.7031626524162414e-08 7.768743874836159 -0.27251360252301193 (ac)ADELS(ph)EKQVYDAHTK ddPTM_A459_Selumetinib_30min_R1 3 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin;Caveolin-1 1 ADELS(0.999)EKQVYDAHTK;ADELS(0.998)EKQVY(0.001)DAHT(0.001)K;ADELS(0.999)EKQVY(0.001)DAHTK 98.676 0.0003739 89128600.0 17222.4 10965.52 43996.0 28634.5 24734.1 21075.300000000003 14065.9 15490.599999999999 10442.369999999999 9938.46 True False 17623.648411043214 9681.67182066806 38021.58485272919 23634.02211113592 22496.905022160016 20863.30161684136 13004.897838478937 15079.73896743981 17719.939209470915 11214.158149798297 1.571553403797877 0.8633436136124225 3.3904983633045216 2.1075163909259667 2.0061162613944994 1.8604429630963084 1.1596856103472064 1.344705395269554 1.5801399420953979 1.0 13.453033700491003 -7.148126176936448 4.299395309689681 1.3014055658691328 2.003581669656246 0.24350362050599128 0.6013985462583542 0.37966625337084947 11.673639197982157 0.24983438714457268 0.19066564045072984 7.110069125766967e-08 7.148126176936448 0.7021761037871133 (ac)ADGDS(ph)GSERGGGGGPCGFQPASR ddPTM_A459_Selumetinib_30min_R1 1 ADGDSGSERGGGGGPCGFQPASR 23 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 ADGDS(0.5)GS(0.5)ERGGGGGPCGFQPASR 70.27199999999999 4.6325e-05 14228000.0 355.9 643.71 741.76 613.57 484.47 611.52 486.75 590.05 389.14 553.71 True False 364.1917775391514 568.3441339473401 641.0330661960268 506.4215176353583 440.64977404012586 605.3686640157355 450.03405561532685 574.3999572474833 660.3421583389129 624.7840720921365 0.5829082299099396 0.9096648895740843 1.026007375715388 0.8105544623433945 0.7052833030211172 0.9689246110077885 0.720303342734641 0.9193575555216409 1.0569126004248275 1.0 9.287213864434847 -8.01678430937877 5.752590748470727 1.0183892033619766 0.8294398897839225 0.312867317619976 0.12446897939623267 0.2228903460210723 25.550337212473554 0.07981484287999117 0.03240150736825316 9.620899778980282e-09 8.01678430937877 -0.1889493135780541 (ac)ADGDS(ph)GSERGGGGGPCGFQPASR ddPTM_A459_Selumetinib_30min_R2 1 ADGDSGSERGGGGGPCGFQPASR 23 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 ADGDS(0.572)GS(0.428)ERGGGGGPCGFQPASR 78.508 2.8545e-05 7992100.0 1581.0 3521.1 3734.1 3398.6 5748.4 2805.8 2888.6 1214.4 886.09 3133.0 True False 1493.134349244451 3791.1570478790263 3493.852071380679 2935.7048170879903 5026.234600651974 3192.2734814835335 3022.9256236523106 1217.933702945258 1063.3327594232046 3042.54214948841 0.4907522314836345 1.2460491462760812 1.1483331700000128 0.9648855045711088 1.6519851997768094 1.049212574432305 0.9935525869906526 0.40030134114988286 0.3494882592183643 1.0 11.571061533940187 -7.6510122304053745 4.782832943905951 0.5340281191042354 1.113493404042904 0.3381334119642013 0.3154753060543068 0.2120073469424707 7.93521720630987 0.15393760528271738 0.08538306871386467 2.233509322862402e-08 7.6510122304053745 0.5794652849386687 (ac)ADGDSGS(ph)ERGGGGGPCGFQPASR ddPTM_A459_Selumetinib_30min_R1 1 ADGDSGSERGGGGGPCGFQPASR 23 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 ADGDS(0.085)GS(0.915)ERGGGGGPCGFQPASR 71.316 3.6942e-05 13469000.0 753.45 391.67 883.83 1021.0 770.02 655.98 581.73 633.42 311.37 413.36 True False 771.0039190415104 345.8130943175571 763.8107405306762 842.701516543672 700.3718269580723 649.3814367821849 537.8496377464902 616.6196439618686 528.372148434978 466.4187824673666 1.65302931190481 0.7414218880470411 1.6376071660109803 1.8067486735541838 1.5015943896021693 1.3922711974568036 1.1531474673923992 1.322030044973609 1.1328277682984305 1.0 8.865482076141005 -7.165196072234981 3.752472463647653 1.1777039972855 1.4554120340546193 0.22483662848583696 0.2763156030310916 0.46001575149678614 11.911890649437323 0.1174527774236026 0.08818855895520782 6.836029493242327e-08 7.165196072234981 0.27770803676911937 (ac)ADGDSGS(ph)ERGGGGGPCGFQPASR ddPTM_A459_Selumetinib_30min_R2 1 ADGDSGSERGGGGGPCGFQPASR 23 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 ADGDS(0.226)GS(0.774)ERGGGGGPCGFQPASR 95.822 3.3292e-16 6604100.0 1165.1 1134.5 1471.2 900.31 779.08 1205.2 629.59 595.2 529.63 1440.3 True False 1100.3484062648392 1221.5125020075411 1376.5445937214465 777.6862248786227 681.2050053364311 1371.2053602836818 658.8671825089177 596.9319334593357 635.5707990986376 1398.7147966511839 0.7866853263433716 0.8733106312538467 0.9841495900502251 0.5560005704812492 0.4870220912564724 0.9803323476427321 0.4710518427962468 0.42677172993988177 0.45439627908443325 1.0 10.449886106061522 -5.768535852973815 24.996735090483522 0.603829250778418 0.880574737569528 0.2494494475773822 0.20138087846446662 208.05514040307943 732859.2217934375 0.05660817022257132 0.0860024714677727 1.7039786423647567e-06 5.768535852973815 0.27674548679111 (ac)ADGGS(ph)PFLGR ddPTM_A459_Selumetinib_30min_R1 1 ADGGSPFLGR 10 0 O60504-2;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 ADGGS(1)PFLGR 112.85 0.00013449 57444000.0 212.32 99.737 150.57 158.29 234.03 122.86 132.14 120.29 0.0 0.0 True False 217.2666428971975 88.05974567352665 130.1234210218073 130.6476229713005 212.8620278213524 121.62413994795463 122.17257341347567 117.09951844301285 0.0 0.0 0.0 (ac)ADGGS(ph)PFLGR ddPTM_A459_Selumetinib_30min_R2 1 ADGGSPFLGR 10 0 O60504-2;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 ADGGS(1)PFLGR 79.82 0.031718 6067300.0 13130.0 14888.0 5717.1 22765.0 21423.0 4588.6 13599.0 13813.0 7646.8 18891.0 True False 12400.287163554496 16029.86172753484 5349.268010307827 19664.36772818456 18731.65121595004 5220.637998836465 14231.380445907296 13853.193543134745 9176.373669443687 18345.56774528744 0.6759282315882456 0.8737729979303883 0.2915836721205825 1.0718865723431148 1.0210450543707907 0.2845721686742308 0.7757394398198996 0.7551248200913987 0.5001956765170643 1.0 14.1631439323036 -10.610280635429282 4.161237358641781 1.000046451548101 0.7006844301313148 0.11248173644096982 0.25696304735646164 130907226.8494231 188452725.64759618 77854.26868532832 0.0632661413358047 2.4531232271836515e-11 10.610280635429282 -0.29936202141678614 (ac)ADGGS(ph)PFLGRR ddPTM_A459_Selumetinib_30min_R2 1 ADGGSPFLGRR 11 1 O60504-2;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 ADGGS(1)PFLGRR 58.23 0.042974 10312000.0 19726.0 14135.0 20479.0 18764.0 13222.0 12221.0 17946.0 13565.0 12107.0 13734.0 True False 18629.707889434576 15219.109048811455 19161.403435849308 16208.310830294544 11560.934153820257 13904.331818807557 18780.524559324374 13604.471904193355 14528.738297844164 13337.463734782581 1.3967953922791503 1.1410796948689546 1.4366602089330192 1.2152468529698883 0.8668015436601085 1.042501940046266 1.4081031396056893 1.0200194110904646 1.0893179233136263 1.0 13.703196727845976 -6.005935585510673 24.43905921465125 1.083313846304356 1.3097160891999293 0.3751290293880536 0.1473602909336474 241.50623700105098 994385.831522346 0.04291208103979877 0.06131607264312566 9.864257812985793e-07 6.005935585510673 0.22640224289557342 (ac)ADHS(ph)FSDGVPSDSVEAAK ddPTM_A459_Selumetinib_30min_R1 2 ADHSFSDGVPSDSVEAAK 18 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;E9PKT8;C9JZI7;E9PNW0;E9PJJ2;E9PKI2;E9PP22;C9J1B1 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 ADHS(0.918)FS(0.082)DGVPSDSVEAAK;ADHS(1)FSDGVPSDSVEAAK 124.25 3.3763000000000005e-25 86534100.0 5004.530000000001 6147.42 6435.49 7704.299999999999 6095.1 5524.99 6314.54 5891.599999999999 3485.42 4555.1 True False 5121.125811879767 5427.677208541976 5561.585805616195 6358.888632622343 5543.799281177307 5469.413616889548 5838.229163934681 5735.335629386105 5914.503174995153 5139.791455431348 0.9963684044939495 1.056011173917652 1.0820644872155516 1.2371880625434215 1.0786039334959854 1.0641314271826885 1.1358883360462566 1.115869326434525 1.150728239906533 1.0 12.327494108610683 -5.059647883027825 2.2687197787013953 1.115623268362519 0.9976336986641434 0.2608843579441765 0.0589286255248627 0.47351168143379957 4.150939518316468 0.015633671099036312 0.08808818813302217 8.716700355451644e-06 5.059647883027825 -0.11798956969837548 (ac)ADHS(ph)FSDGVPSDSVEAAK ddPTM_A459_Selumetinib_30min_R2 5 ADHSFSDGVPSDSVEAAK 18 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;E9PKT8;C9JZI7;E9PNW0;E9PJJ2;E9PKI2;E9PP22;C9J1B1 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 ADHS(0.838)FS(0.124)DGVPS(0.033)DS(0.004)VEAAK;ADHS(0.875)FS(0.116)DGVPS(0.001)DS(0.008)VEAAK;ADHS(1)FSDGVPSDSVEAAK;ADHS(0.821)FS(0.179)DGVPSDSVEAAK;ADHS(1)FSDGVPSDSVEAAK 167.44 1.726999999999999e-67 199477100.0 181499.6 199620.8 207462.80000000002 226443.8 230374.0 168434.09999999998 174698.1 185794.6 151807.0 219810.5 True False 171412.57883246566 214931.0734779611 194114.86931641755 195601.7638026571 201432.35855030932 191634.36838247417 182821.90780771783 186335.23152604824 182172.6418419785 213463.99972873324 0.8030046239660745 1.006872698680303 0.9093564702389899 0.9163220217517933 0.9436362047290712 0.8977362394876897 0.856453116403914 0.8729117404472894 0.8534115451480375 1.0 17.703633257199904 -6.989999822158006 21.93275145508824 0.8839593076191281 0.9205750176551033 0.008367678989492422 0.061010734089950634 130.52119978166385 286256.5281142814 0.020197462599918652 0.01777627905339301 1.0232934113155595e-07 6.989999822158006 0.03661571003597519 (ac)ADHSFS(ph)DGVPSDSVEAAK ddPTM_A459_Selumetinib_30min_R1 3 ADHSFSDGVPSDSVEAAK 18 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;E9PKT8;C9JZI7;E9PNW0;E9PJJ2;E9PKI2;E9PP22;C9J1B1 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 ADHS(0.044)FS(0.956)DGVPSDSVEAAK;ADHS(0.349)FS(0.518)DGVPS(0.109)DS(0.024)VEAAK;ADHS(0.12)FS(0.681)DGVPS(0.183)DS(0.016)VEAAK 117.4 7.916099999999997e-96 74124000.0 3924.2 4360.12 4567.93 5273.0 4353.81 3744.35 4131.16 3436.73 2011.5300000000002 2800.0800000000004 True False 4015.6262248360117 3849.635123435203 3947.630195843422 4352.169536468934 3960.008654227589 3706.685238597785 3819.543275184003 3345.576756327672 3413.4194936615972 3159.497543088892 1.270969883682873 1.2184327004323592 1.2494487310105675 1.3774878685976197 1.2533665876366136 1.1731882009865193 1.2089084492370945 1.0588951916249503 1.0803678265641117 1.0 11.625479428592666 -7.662783762323883 0.9457600322159169 1.0133816857607016 1.2742782237417538 0.8010868341104341 0.04803648416250785 0.2562103455281175 0.4177164263723442 0.04382150125034243 0.01915978154363334 2.1737832484174457e-08 7.662783762323883 0.26089653798105217 (ac)ADHSFSDGVPS(ph)DSVEAAK ddPTM_A459_Selumetinib_30min_R1 1 ADHSFSDGVPSDSVEAAK 18 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;E9PKT8;C9JZI7;E9PNW0;E9PJJ2;E9PKI2;E9PP22;C9J1B1 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 ADHS(0.026)FS(0.006)DGVPS(0.742)DS(0.226)VEAAK 154.47 1.3574999999999989e-183 90754000.0 1883.5 2400.0 2510.9 2973.9 2008.9 2172.3 2297.6 2034.0 912.07 1619.9 True False 1927.3818853469827 2119.006884270271 2169.9335713864384 2454.5641920168728 1827.1953497001011 2150.4486342905907 2124.2901821916284 1980.0517126368618 1547.7161750428443 1827.8299441621996 1.0544645531728682 1.1593019859632152 1.1871638159320368 1.342884331147087 0.9996528153704204 1.1765036682754784 1.1621924615997654 1.0832800496352708 0.8467506400067498 1.0 10.835916137264686 -8.068582160961547 4.271320835837852 0.9264363065367592 1.1567605850743021 0.4989800660951391 0.09129898731811599 0.18314097508880328 6.326054297558856 0.06525490241842567 0.023608021775857847 8.539212850832142e-09 8.068582160961547 0.2303242785375429 (ac)ADKEAAFDDAVEER ddPTM_A459_Selumetinib_30min_R2 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS2;E9PIC4;E9PNS6 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 80.87100000000002 0.0014282 2258100.0 13335.0 18743.0 20367.0 17655.0 15664.0 15293.0 17071.0 15234.0 13128.0 19366.0 False True 12593.894084234515 20180.52783175615 19056.60939391292 15250.35854342625 13696.148282063266 17399.47193396809 17864.835325544766 15278.328417875537 15753.966826967724 18806.853261089233 0.6696438744641493 1.0730411702370755 1.0132800596333904 0.8108936849621061 0.7282530517957596 0.9251665705270871 0.9499109222331483 0.8123809020983803 0.8376715981275915 1.0 14.198970858692542 -4.915739125775882 0.005519115129002465 1.7444263060285408 2.6996686383349623e-07 0.03002432659957588 0.12250954780222525 194008.83187922975 174.71867831972165 26563.741877136123 28686.768686338186 1.2141179340203657e-05 4.915739125775882 -1.744426036061677 (ac)ADKPDMGEIAS(ph)FDK ddPTM_A459_Selumetinib_30min_R2 3 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 1 ADKPDMGEIAS(1)FDK;ADKPDMGEIAS(1)FDK;ADKPDMGEIAS(1)FDK 88.28200000000002 0.0013033 9707300.0 62487.0 52913.0 55478.0 45898.0 43296.0 36441.0 53989.0 46457.0 39250.2 46672.0 True False 59014.2226952802 56971.256957889 51908.60587987927 39646.61322153371 37856.76940884901 41460.41697153803 56499.59547717396 46592.18217862965 47101.336742218766 45324.45809158092 1.3020392340055837 1.256964988809684 1.1452669941468394 0.8747288967344129 0.8352393167582285 0.9147471082338071 1.2465586541159075 1.027969977809491 1.0392035277520042 1.0 15.46800215046731 -5.497937184341995 3.740352068296016 0.9932924886631068 1.2725816010158786 0.5390813722500116 0.10740299938958364 0.19337657263798133 5.782960749498414 0.033045791205682226 0.06908042246577918 3.1773336018572616e-06 5.497937184341995 0.27928911235277176 (ac)ADKPDMGEIASFDK ddPTM_A459_Selumetinib_30min_R1 1 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 0 95.018 6.4067e-05 27342000.0 2133.8 2176.4 2594.4 2729.5 2381.1 2080.7 2411.3 2113.1 1382.2 1702.2 False True 2183.5133883479657 1921.5860762190894 2242.0947300191065 2252.8440640606777 2165.729925417349 2059.770047124444 2229.413699651234 2057.0537236838504 2345.492448106199 1920.6939508320875 1.136835666818245 1.0004644807605165 1.1673357585406987 1.1729323472303828 1.1275767930018765 1.0724092957298614 1.1607334415175319 1.0709950550907337 1.221169279514875 1.0 10.907411938599022 -5.279898133475572 24.98521621189185 1.1280036711120833 1.0686500503729988 0.09587668661099158 0.06733577162094671 1496.682721053192 2025862.0634650358 0.016403295061827732 0.03423040510219774 5.249305716048903e-06 5.279898133475572 -0.05935362073908457 (ac)ADKPDMGEIASFDK ddPTM_A459_Selumetinib_30min_R2 3 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 0 ;; 103.08 0.00024565 55808600.0 255039.0 251801.0 286241.0 255169.0 259581.0 168822.0 211591.0 208320.0 172166.0 232126.0 False True 240864.95338200888 271113.32703217375 267824.5656956371 220414.54200892313 226970.1140964165 192075.69808646827 221430.40075961238 208926.17671076753 206604.01071996655 225423.9192442213 1.0684977627465477 1.2026821640806145 1.1880929343859001 0.9777779693827829 1.0068590540763338 0.8520644070533437 0.9822844066503769 0.9268145874281409 0.9165132582764409 1.0 17.78228107931767 -5.834383135457803 4.766793712817818 0.9452692527049715 1.158128105312972 0.743972854267392 0.05419976809032311 0.09506885164723654 4.016174325410193 0.015279918281751228 0.0235880828409884 1.464255501864585e-06 5.834383135457803 0.21285885260800042 (ac)ADLEEQLS(ph)DEEKVR ddPTM_A459_Selumetinib_30min_R1 2 ADLEEQLSDEEKVR 14 1 C9JUG7;F8W9N7;P47755-2;P47755 C9JUG7 CAPZA2 F-actin-capping protein subunit alpha-2 1 ADLEEQLS(1)DEEKVR;ADLEEQLS(1)DEEKVR 108.66 0.0014396 59387000.0 3919.6 4358.9 5630.9 6703.700000000001 4377.9 4304.7 4119.7 3927.5 2497.54 3837.0 True False 4010.919053786056 3848.557961602368 4866.254708319684 5533.024639034094 3981.919717981021 4261.398626354876 3808.9477122105027 3823.329941682044 4238.142966895639 4329.516325545011 0.9264127334780637 0.8889117564692175 1.1239719041149723 1.277977543678065 0.9197146790940365 0.9842666722866417 0.8797628709093787 0.8830847730319514 0.9788952502360944 1.0 12.079990147093662 (ac)ADLEEQLS(ph)DEEKVR ddPTM_A459_Selumetinib_30min_R2 2 ADLEEQLSDEEKVR 14 1 C9JUG7;F8W9N7;P47755-2;P47755 C9JUG7 CAPZA2 F-actin-capping protein subunit alpha-2 1 ADLEEQLS(1)DEEKVR;ADLEEQLS(1)DEEKVR 126.71 0.0019699 22612500.0 43447.0 44945.0 41756.0 42037.0 35046.0 25659.0 30658.0 35975.0 19073.9 32705.0 True False 41032.38967212126 48392.1369790471 39069.46442049531 36311.48808213022 30643.20816478481 29193.29434078906 32083.657747674522 36079.68129401816 22889.2129692946 31760.72167220505 1.2919224599367394 1.5236472734622022 1.2301189130310726 1.1432828402607649 0.9648146059477541 0.9191634447757893 1.010167781412602 1.1359843037065744 0.7206767278630754 1.0 14.954956073550555 -5.7976191667390875 1.6821567065830738 0.965246858829838 1.4075537777640421 0.7061955918278098 0.11485317183116421 0.19367361941939887 1.1163935187337921 0.03544820591322756 0.0728864543466088 1.5936055488070836e-06 5.7976191667390875 0.44230691893420415 (ac)ADQLTEEQIAEFK ddPTM_A459_Selumetinib_30min_R1 3 ADQLTEEQIAEFK 13 0 P0DP25;P0DP24;P0DP23;M0QZ52;F8WBR5;G3V479 P0DP25 CALM3;CALM2;CALM1 0 ;; 196.27 1.0567999999999993e-59 17369900.0 13552.899999999998 14743.3 14456.499999999998 15635.0 15419.1 13723.800000000001 13421.1 14289.7 8742.9 11699.7 False True 13868.65620064727 13017.147582025775 12493.386703870347 12904.640755299033 14024.44512746321 13585.751032213415 12408.735621610396 13910.690736512764 14836.062743848695 13201.47045972869 1.0505387443735033 0.9860377010072329 0.9463632662726198 0.9775154059288214 1.0623396211993974 1.02910892189298 0.9399510198097595 1.0537228242071641 1.1238189555554707 1.0 13.688411014194196 -7.979095193873441 24.134832488735988 1.070863293599808 0.9989500734025775 0.25256709373937036 0.04720966568126804 183.02649561593051 211305.66095281794 0.02594544625291196 0.012461726083154911 1.0493124025655318e-08 7.979095193873441 -0.07191322019723045 (ac)ADQLTEEQIAEFK ddPTM_A459_Selumetinib_30min_R2 1 ADQLTEEQIAEFK 13 0 P0DP25;P0DP24;P0DP23;M0QZ52;F8WBR5;G3V479 P0DP25 CALM3;CALM2;CALM1 0 178.54 3.0568e-17 8994200.0 93298.0 93675.0 99005.0 108760.0 98867.0 80228.0 84753.0 85370.0 73138.0 91006.0 False True 88112.87066148558 100859.57128740106 92635.12608849372 93946.70037853505 86446.44357780565 91278.67876272753 88694.1824348836 85618.41256623573 87767.64364646292 88378.42031801525 0.9969953111226232 1.141223965357996 1.048164537849414 1.0630049738441043 0.9781397230991717 1.032816364382574 1.0035728418287193 0.9687705693103804 0.9930890745800326 1.0 16.431406524044085 -6.248274858613838 21.92539150090981 0.9967162829122788 1.0669682470634134 0.44052159258303447 0.036441226879456355 134.74904327986386 224421.31549881332 0.01041852328053508 0.013333054488994365 5.645795475961734e-07 6.248274858613838 0.07025196415113466 (ac)ADQLTEEQVTEFK ddPTM_A459_Selumetinib_30min_R1 2 ADQLTEEQVTEFK 13 0 P27482 P27482 CALML3 Calmodulin-like protein 3 0 ; 112.75 0.0011352 6637200.0 2836.6000000000004 2963.3 3570.2 3376.3 3356.1 3163.6000000000004 3114.8 2943.4 1741.4 2896.0 False True 2902.687260937221 2616.3554583992063 3085.3864497048303 2786.6925860003917 3052.541347567579 3131.777056318977 2879.848128260132 2865.331470489352 2955.0286131761904 3267.729809428812 0.8882886377452976 0.8006645625503953 0.9441987647822526 0.8527916163568908 0.9341474129102347 0.9583953505832848 0.8812993411972208 0.8768569121662485 0.904306287701528 1.0 11.674072984574074 (ac)ADVLDLHEAGGEDFAMDEDGDES(ph)IHK ddPTM_A459_Selumetinib_30min_R1 1 ADVLDLHEAGGEDFAMDEDGDESIHK 26 0 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 1 ADVLDLHEAGGEDFAMDEDGDES(1)IHK 73.87 1.7748e-13 2637300.0 266.7 606.98 266.44 185.0 359.39 229.38 469.38 431.23 226.3 162.06 True False 272.9135910921372 535.9144994226539 230.25891145015837 152.69322288009724 326.8832379554579 227.07264546037626 433.974288699994 419.79237956754883 384.01457170194817 182.86197959807777 1.4924567244212752 2.930704898856336 1.2591951151150003 0.8350189755995747 1.7875954240128662 1.2417706838757379 2.3732341170857363 2.2956788529263066 2.100024141409792 1.0 7.514611332946267 -7.265152819452188 24.987398920049685 2.050207496245779 1.6114881802699907 0.05922904285013708 0.6260384096747059 834.4666192484752 5615013.880069486 0.2610122722103748 0.1836242855709825 5.43059206307014e-08 7.265152819452188 -0.4387193159757883 (ac)AEAEES(ph)PGDPGTASPR ddPTM_A459_Selumetinib_30min_R2 1 AEAEESPGDPGTASPR 16 0 B1AV70;Q96EC8-2;Q96EC8 B1AV70 YIPF6 Protein YIPF;Protein YIPF6 1 AEAEES(0.999)PGDPGT(0.001)ASPR 85.90899999999998 0.0056151000000000005 805780.0 964.51 1093.7 1018.1 1084.4 651.62 992.96 1226.9 877.6 538.22 1028.5 True False 910.9063954394469 1177.583273200219 952.5965544234666 936.7028493056605 569.7576700432883 1129.7312268065753 1283.953281056228 880.1536707054985 645.8790391232911 998.804532636077 0.9119966576797098 1.1789927205199033 0.9537367155406705 0.9378239872755525 0.5704396119825023 1.1310834000972665 1.2854900424486233 0.8812071250643693 0.6466520905934081 1.0 9.964058558094067 -5.497760198645723 22.67369751214483 0.927610330101292 1.050712284874848 0.05313534026342126 0.20473968078872368 783.8880276229369 707583.598710015 0.056856018764630936 0.11725475754378707 3.1786287074205273e-06 5.497760198645723 0.12310195477355601 (ac)AEAPAS(ph)PAPLSPLEVELDPEFEPQSRPR ddPTM_A459_Selumetinib_30min_R1 1 AEAPASPAPLSPLEVELDPEFEPQSRPR 28 1 O43524 O43524 FOXO3 Forkhead box protein O3 1 AEAPAS(0.978)PAPLS(0.022)PLEVELDPEFEPQSRPR 117.35 2.0316e-12 4144100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)AEAS(ph)PHPGR ddPTM_A459_Selumetinib_30min_R2 2 AEASPHPGR 9 0 U3KQF4;K7EIY6;Q9BV68 U3KQF4 RNF126 E3 ubiquitin-protein ligase RNF126 1 AEAS(1)PHPGR;AEAS(1)PHPGR 82.26100000000002 0.004379 7607800.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)AEDVSSAAPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AEDVSSAAPSPR 12 0 P54274;P54274-2;E5RFJ5 P54274 TERF1 Telomeric repeat-binding factor 1 1 AEDVSSAAPS(1)PR 98.654 0.0012790999999999998 3799200.0 29880.0 22898.0 34676.0 27820.0 25752.0 25732.0 29519.0 26998.0 32468.0 26421.0 True False 28219.389219117147 24654.202971325438 32444.98391237414 24030.868007823174 22516.803534199007 29276.349428161062 30891.69199078884 27076.559710240508 38962.50723171756 25658.157079997844 1.0998213601675992 0.9608719322458645 1.264509520742901 0.9365781000131438 0.8775690110554464 1.1410152855827602 1.2039715827786739 1.0552807680543979 1.5185232170120004 1.0 14.64712993084104 -6.987151945482858 24.230127455491736 1.1952567695238219 1.0299296445502482 0.19574126282418047 0.16090538910730232 264.1424880360616 498142.7379275689 0.05530356389496877 0.048741112589060165 1.0300256849807556e-07 6.987151945482858 -0.1653271249735737 (ac)AENHCELLS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 AENHCELLSPAR 12 0 H3BSS5;Q9NXV2 H3BSS5 KCTD5 BTB/POZ domain-containing protein KCTD5 1 AENHCELLS(1)PAR 67.118 0.0043996 12722000.0 5959.0 5772.2 10410.0 18076.0 10590.0 4853.1 5231.5 3612.8 11500.0 11463.0 True False 5627.822635767039 6214.909179451679 9740.23193355102 15614.017617160747 9259.589524198798 5521.570472944524 5474.775116020587 3623.312649868765 13800.321336847093 11132.033405549195 0.5055520793677849 0.5582905613949753 0.8749732936208782 1.4026204421356958 0.8317967784378905 0.4960073574870951 0.4918036908954542 0.32548524765139353 1.2396945673885407 1.0 13.4424295226478 -6.608455786026366 10.523673871021934 0.6552263500249488 0.8555994214285212 0.018645898648652404 0.33642217661485424 1.1950629154412926 138.17244298874118 0.11611184786614831 0.11608189542335785 2.4634526208023366e-07 6.608455786026366 0.2003730714035724 (ac)AEPPS(ph)PVHCVAAAAPTATVSEK ddPTM_A459_Selumetinib_30min_R1 1 AEPPSPVHCVAAAAPTATVSEK 22 0 Q6PCB5 Q6PCB5 RSBN1L Round spermatid basic protein 1-like protein 1 AEPPS(1)PVHCVAAAAPTATVSEK 91.657 0.00097596 0.0 608.55 704.64 597.47 516.9 731.24 428.85 543.03 701.41 456.68 572.64 True False 622.7280309678292 622.1404212217512 516.3368556677902 426.6331184147151 665.0994711109079 424.53615836464536 502.0688099040385 682.8063282992239 774.9526054124862 646.1439219859515 0.9637605644480064 0.9628511544449347 0.7991050261384591 0.6602756814665062 1.0293364194569774 0.6570303363062133 0.7770231875909445 1.0567403098068135 1.1993498337500963 1.0 9.335711736132529 -7.847043266675961 5.391689363126811 1.1063272574020857 0.8332986285206686 0.45337318687722283 0.12582162999217658 0.18495792852217957 8.765844150573663 0.07166347323720818 0.033786372372209196 1.4221870943867425e-08 7.847043266675961 -0.2730286288814171 (ac)AEPPS(ph)PVHCVAAAAPTATVSEK ddPTM_A459_Selumetinib_30min_R2 2 AEPPSPVHCVAAAAPTATVSEK 22 0 Q6PCB5 Q6PCB5 RSBN1L Round spermatid basic protein 1-like protein 1 AEPPS(1)PVHCVAAAAPTATVSEK;AEPPS(1)PVHCVAAAAPTATVSEK 86.49700000000001 2.9256e-05 14424700.0 59512.0 48925.0 57321.0 51570.0 63835.0 59746.0 69084.0 61969.0 63986.0 51483.0 True False 56204.56128541167 52677.390181330105 53633.02926638594 44546.07703678798 55815.47660785932 67975.46917981151 72296.54288734903 62149.31953047977 76784.98791821723 49996.55202110175 1.1241687479106508 1.0536204608489175 1.0727345606502898 0.89098298254621 1.1163865177002927 1.359603141255051 1.446030575405185 1.2430721123378423 1.5358056668749684 1.0 15.60954098336519 -6.664919129924603 4.346439464319805 1.3401612680440846 1.0359449808482055 0.4621157802575684 0.14371720842189423 0.17431050051332714 5.902240154450499 0.04610002107987041 0.04556491029605234 2.1631212815385676e-07 6.664919129924603 -0.3042162871958791 (ac)AEPPS(ph)PVHCVAAAAPTATVSEKEPFGK ddPTM_A459_Selumetinib_30min_R1 2 AEPPSPVHCVAAAAPTATVSEKEPFGK 27 1 Q6PCB5 Q6PCB5 RSBN1L Round spermatid basic protein 1-like protein 1 AEPPS(1)PVHCVAAAAPTATVSEKEPFGK;AEPPS(1)PVHCVAAAAPTATVSEKEPFGK 113.51 6.0029e-13 99757000.0 5459.2 4900.5 7514.200000000001 7559.5 6305.700000000001 5510.1 6286.4 6290.0 3204.2 4208.4 True False 5586.388738245951 4326.747181819357 6493.81291254609 6239.375234389705 5735.350548361754 5454.673396770509 5812.211786790325 6123.168767200523 5437.293374491301 4748.589133287364 1.176431268623696 0.9111647818694364 1.3675246963408136 1.3139429542665646 1.207800967271993 1.1486934842464112 1.2239870883010326 1.2894711661359426 1.1450334450660629 1.0 12.213283218577475 -12.057709085297457 0.989986059606363 0.3214706660241633 1.200471217062808 0.20230414514724937 0.11803636547212674 12117.270957502162 857.1738971311944 18026.988220913358 0.037663810505986814 8.75570084583864e-13 12.057709085297457 0.8790005510386447 (ac)AEPPS(ph)PVHCVAAAAPTATVSEKEPFGK ddPTM_A459_Selumetinib_30min_R2 4 AEPPSPVHCVAAAAPTATVSEKEPFGK 27 1 Q6PCB5 Q6PCB5 RSBN1L Round spermatid basic protein 1-like protein 1 AEPPS(0.999)PVHCVAAAAPTATVSEKEPFGK;AEPPS(0.999)PVHCVAAAAPTATVSEKEPFGK;AEPPS(1)PVHCVAAAAPTATVSEKEPFGK;AEPPS(1)PVHCVAAAAPTATVSEKEPFGK 127.96 5.6634e-14 161287000.0 377896.0 376950.0 411640.0 446399.0 418489.0 338101.0 333171.0 348940.0 263786.0 390399.0 True False 356894.0531575463 405860.8529147129 385155.5305597438 385598.68611877284 365914.6704808719 384671.343774704 348664.11166581203 349955.35762987344 316550.5707966558 379127.16649158177 0.9413571083819204 1.070513771594167 1.0159006386272662 1.0170695223111499 0.965150226155046 1.0146235294464063 0.9196495067666269 0.9230553454355108 0.8349456297895882 1.0 18.53232231147414 -7.291925224759514 5.658313419405407 0.9121309056597566 1.0065886753449595 0.4126222744248119 0.04915688533654692 0.17335905501235346 17.088022346394848 0.01982641144372498 0.013586592604725764 5.1059290443235276e-08 7.291925224759514 0.09445776968520292 (ac)AEQLS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 AEQLSPGK 8 0 O15541 O15541 RNF113A RING finger protein 113A 1 AEQLS(1)PGK 94.692 0.0015038 12693000.0 3011.0 3551.6 2269.6 2435.8 2227.6 2698.5 2729.1 2952.7 1917.7 2952.5 True False 3081.1504416138914 3135.777020905956 1961.4007860204158 2010.433255628871 2026.1139733147231 2671.3555400419636 2523.2417897889854 2874.384804278692 3254.1968367336526 3331.4821347854145 0.9248587616431426 0.9412558417060026 0.5887472021958636 0.6034651168130505 0.6081719461014693 0.8018519781778837 0.757393162473468 0.8627946025182078 0.9768015270906624 1.0 11.701948441775388 -8.019325507621309 1.6244718250967234 1.0033182191453947 0.734534068800089 0.40690921243725386 0.11734939615526499 0.4338722166393746 2.0510176660644452 0.11666940413015106 0.03842036079472236 9.564769145183307e-09 8.019325507621309 -0.2687841503453057 (ac)AESSES(ph)FTMASSPAQRR ddPTM_A459_Selumetinib_30min_R1 1 AESSESFTMASSPAQRR 17 1 P49736;F8WDM3 P49736 MCM2 DNA replication licensing factor MCM2 1 AESSES(0.484)FT(0.194)MAS(0.194)S(0.127)PAQRR 58.817 0.0067062 3513100.0 768.56 780.58 905.76 1008.2 681.33 659.23 963.69 842.58 416.43 743.64 True False 786.4659526425684 689.1893307182036 782.7627669835439 832.1367962579144 619.7038217985815 652.598744732949 890.9980874287297 820.2320413144383 706.651295156174 839.0934376670034 0.9372805427119544 0.8213499233582497 0.9328672253234633 0.9917093364137954 0.73853970723641 0.7777426391838076 1.061858009408393 0.9775216972200297 0.8421604358162202 1.0 9.71268766140891 -7.260173311423319 24.999981125909862 0.9685118402851478 0.8674061077334195 0.2509462090758643 0.08782768546366994 187.24914046783016 3697510.590238507 0.03665617381114215 0.026795936374317843 5.493216154656061e-08 7.260173311423319 -0.10110573255172828 (ac)AESSESFTMAS(ph)SPAQR ddPTM_A459_Selumetinib_30min_R2 2 AESSESFTMASSPAQR 16 0 P49736;F8WDM3 P49736 MCM2 DNA replication licensing factor MCM2 1 AESSESFTMAS(0.915)S(0.085)PAQR;AESSESFTMAS(0.686)S(0.313)PAQR 212.03 1.8865999999999996e-50 101052000.0 4854.1 5595.1 1647.3 6654.200000000001 1986.5 3368.4 4783.9 4486.9 1081.9 1820.7 True False 4584.328554501895 6024.2261789179365 1541.3145114446284 5747.88648086474 1736.938110464675 3832.366524709221 5006.360829118017 4499.956136153719 1298.3102308117295 1768.1316602532863 2.592752936647934 3.407114025691368 0.8717193103277353 3.2508249301080614 0.9823579032660142 2.1674667169074 2.8314411995772146 2.5450345340850333 0.7342836848618759 1.0 10.788009990682365 -8.792433730398276 0.12017849967342502 2.678716237981197e-21 3.358313504935378 0.2094680112326185 0.8805540119772058 23.9638664518859 1.5906483769573188 24.778265618427376 15.972827851122767 1.612747099896045e-09 8.792433730398276 3.358313504935378 (ac)AESSESFTMASS(ph)PAQR ddPTM_A459_Selumetinib_30min_R1 2 AESSESFTMASSPAQR 16 0 P49736;F8WDM3 P49736 MCM2 DNA replication licensing factor MCM2 1 AESSESFTMAS(0.087)S(0.913)PAQR;AES(0.001)S(0.005)ES(0.003)FT(0.2)MAS(0.079)S(0.712)PAQR 137.27 1.132e-06 28589000.0 1047.06 1193.45 1711.1499999999999 1802.1599999999999 1658.51 1451.4 1245.23 1318.49 1023.37 1224.09 True False 1071.4544607759021 1053.7203191801482 1478.7852286741415 1487.4465867329511 1508.4980633337223 1436.8002337657606 1151.3012985595753 1283.519362140893 1736.5841460124718 1381.2138751463092 0.7757339251043979 0.7628943917671908 1.0706417415025582 1.0769125719761459 1.0921538586295552 1.040244570098576 0.8335431023943488 0.9292690909327366 1.2572883731192745 1.0 10.431721016801404 -5.25698839203911 24.77827857973134 1.0311529711636043 0.7693141207583893 0.5126952941576768 0.10444003829667424 274.4974678714486 1528088.1386972917 0.028033126371389914 0.06899644229966814 5.53364899530917e-06 5.25698839203911 -0.26183885040521493 (ac)AESSESFTMASS(ph)PAQR ddPTM_A459_Selumetinib_30min_R2 2 AESSESFTMASSPAQR 16 0 P49736;F8WDM3 P49736 MCM2 DNA replication licensing factor MCM2 1 AESSESFT(0.001)MAS(0.289)S(0.71)PAQR;AES(0.004)SES(0.05)FT(0.078)MAS(0.27)S(0.599)PAQR 129.88 3.0641e-20 14496000.0 6031.8 5238.6 6285.4 6778.799999999999 8966.8 5312.9 5240.5 6147.3 3050.7 4815.3 True False 5696.576703208528 5640.383775246108 5881.004207026088 5855.515745917746 7840.310419790918 6044.703749295693 5484.193633853752 6165.187625259698 3660.925243679951 4676.269777348081 1.2181882086450246 1.2061715948400173 1.2576272300442881 1.2521766332391577 1.6766163615644023 1.292633666812023 1.1727710108641005 1.3183986208674179 0.7828729773918361 1.0 12.191142447041324 -8.253530793405906 24.94885100150337 0.8914364805797984 1.3013915616753966 0.5690072083175788 0.1419866186659186 385.3675275736213 1215710.911419657 0.10476844403142993 0.037998936337351824 5.57788051091093e-09 8.253530793405906 0.4099550810955982 (ac)AESSESFTMASS(ph)PAQRR ddPTM_A459_Selumetinib_30min_R1 1 AESSESFTMASSPAQRR 17 1 P49736;F8WDM3 P49736 MCM2 DNA replication licensing factor MCM2 1 AESS(0.002)ES(0.022)FT(0.218)MAS(0.179)S(0.579)PAQRR 55.975 0.0013203 3327600.0 770.07 763.15 847.8 821.9 799.48 612.39 585.06 591.19 424.55 560.2 True False 788.0111327046199 673.80004322119 732.6734166320529 678.3705939737941 727.1671751596585 606.2299126056321 540.9284531654914 575.5097207442415 720.4303420948386 632.1071268100898 1.2466417467578559 1.0659586241678722 1.1590969086671559 1.0731892826413327 1.150385977815638 0.9590619799921474 0.8557543970359441 0.9104623193358609 1.1397282383612242 1.0 9.304025270678013 -6.764865188183065 24.97166737538489 0.9600773148983014 1.1324479242852212 0.495119904402622 0.08319784606901813 73.81490453061521 538052.3642777458 0.028665338429707643 0.02628884335757311 1.7184417356334058e-07 6.764865188183065 0.17237060938691984 (ac)AESSESFTMASS(ph)PAQRR ddPTM_A459_Selumetinib_30min_R2 1 AESSESFTMASSPAQRR 17 1 P49736;F8WDM3 P49736 MCM2 DNA replication licensing factor MCM2 1 AESSES(0.001)FT(0.01)MAS(0.016)S(0.973)PAQRR 94.922 5.9764e-06 0.0 2345.8 1342.5 2940.0 2521.5 2670.1 834.57 2515.0 2553.1 1131.9 2815.8 True False 2215.4298269814267 1445.465433182128 2750.84360082997 2178.0673501698834 2334.658167003136 949.5244420278401 2631.952483377958 2560.529098311541 1358.3116279284554 2734.500537672987 0.810177140746412 0.5286030897665116 1.0059766172768394 0.7965137765243891 0.8537786461691063 0.3472387110356428 0.9624984333035473 0.9363790802142271 0.49673116140044915 1.0 11.41706163043119 -11.332334898090433 2.511808338415136 1.0816075266801328 0.7542552449599913 0.1144792084536369 0.20919271922255753 68360626.45952758 44487699.12093503 33866403.385153465 0.05084798291030254 4.652272038831021e-12 11.332334898090433 -0.3273522817201415 (ac)AFAETYPAAS(ph)SLPNGDCGRPR ddPTM_A459_Selumetinib_30min_R1 1 AFAETYPAASSLPNGDCGRPR 21 1 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 1 AFAETYPAAS(0.668)S(0.332)LPNGDCGRPR 73.928 0.00017339 4515400.0 0.0 152.07 0.0 180.35 171.16 191.37 118.27 165.51 0.0 0.0 True False 0.0 134.26557370457502 0.0 148.85525808878668 155.67860822075238 189.4449915500576 109.3487986802767 161.12013714775173 0.0 0.0 0.0 (ac)AFAETYPAASS(ph)LPNGDCGRPR ddPTM_A459_Selumetinib_30min_R1 1 AFAETYPAASSLPNGDCGRPR 21 1 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 1 AFAET(0.006)YPAAS(0.26)S(0.734)LPNGDCGRPR 75.91 0.00026596 3959500.0 219.44 180.18 211.64 359.21 294.46 207.41 350.78 209.87 143.14 287.33 True False 224.5525250440893 159.08444183659054 182.9004504553052 296.4807167068093 267.82614499113544 205.3236437132123 324.32038218540197 204.30356584616428 242.89812546803728 324.2116043312087 0.6926110048013288 0.49068090010150517 0.5641391239915564 0.9144667024439074 0.8260843887547255 0.6333013407609476 1.0003355149931097 0.6301550071522161 0.7491962725057087 1.0 8.340791919160328 -3.3452474433610733 0.10895554646797306 1.0598776365274996 3.230040859712433e-21 0.31354776596710265 0.14135313921160145 96.798105765902 1.1353644691827425 1.7140098651480726 15.235098492367236 0.0004515985685337378 3.3452474433610733 -1.0598776365274996 (ac)AFS(ph)QVQCLDDNHVNWR ddPTM_A459_Selumetinib_30min_R1 2 AFSQVQCLDDNHVNWR 16 0 A6ND36 A6ND36 FAM83G Protein FAM83G 1 AFS(1)QVQCLDDNHVNWR;AFS(1)QVQCLDDNHVNWR 243.53 9.924899999999993e-135 60221000.0 169.978 0.0 170.446 113.66 132.68 0.0 177.52 0.0 0.0 0.0 True False 173.93815668038738 0.0 147.30036939286023 93.81141466244244 120.67911742655662 0.0 164.1295234778281 0.0 0.0 0.0 0.0 (ac)AFS(ph)QVQCLDDNHVNWR ddPTM_A459_Selumetinib_30min_R2 2 AFSQVQCLDDNHVNWR 16 0 A6ND36 A6ND36 FAM83G Protein FAM83G 1 AFS(1)QVQCLDDNHVNWR;AFS(1)QVQCLDDNHVNWR 185.77 8.7341e-12 19454300.0 2232.24 1214.6 1015.5 922.88 3395.7 2155.2 0.0 0.0 0.0 1963.5 True False 2108.181037164728 1307.7559144454472 950.1638355928005 797.1821519432009 2969.1018080568338 2452.059237042309 0.0 0.0 0.0 1906.8086532143293 1.1056070222940004 0.6858348960400132 0.4983005683297579 0.41807139410626326 1.5571052727560182 1.2859492917177844 0.0 0.0 0.0 1.0 10.89694436223553 -7.2721403956321 24.9504961337507 0.1666666337782269 0.9005417074452218 0.36606163358806154 0.4289660923518079 769.4762202826959 1794104.0872112752 0.18633357145041485 0.12707011052492379 5.343915771612462e-08 7.2721403956321 0.7338750736669949 (ac)AGS(ph)PELVVLDPPWDK ddPTM_A459_Selumetinib_30min_R1 4 AGSPELVVLDPPWDK 15 0 Q5SY74;Q96IY1-2;Q96IY1 Q5SY74 NSL1 Kinetochore-associated protein NSL1 homolog 1 AGS(1)PELVVLDPPWDK;AGS(1)PELVVLDPPWDK;AGS(1)PELVVLDPPWDK;AGS(1)PELVVLDPPWDK 120.86 3.43e-06 57981400.0 28120.9 36630.9 23158.0 23097.800000000003 25569.399999999998 24710.6 32092.9 29001.3 16369.699999999999 29134.1 True False 28776.062256253776 32342.1371987566 20013.270797788504 19064.20282940492 23256.652284644217 24462.03379942966 29672.106714857964 28232.091314501202 27778.185304416147 32873.74552516574 0.8753508855334092 0.9838287874437011 0.6087919243174711 0.5799218350343059 0.7074536811401859 0.7441206777214758 0.9026080308416079 0.8588036094910079 0.844996055686785 1.0 15.004648221204468 -7.258213677740737 23.04178876991941 0.8898355667329361 0.7444726951522194 0.28523868014873843 0.11685466763562789 150.78924298298 1077127.5890344465 0.05131540610731001 0.037994714140843266 5.518058778192312e-08 7.258213677740737 -0.1453628715807167 (ac)AGS(ph)PELVVLDPPWDK ddPTM_A459_Selumetinib_30min_R2 3 AGSPELVVLDPPWDK 15 0 Q5SY74;Q96IY1-2;Q96IY1 Q5SY74 NSL1 Kinetochore-associated protein NSL1 homolog 1 AGS(1)PELVVLDPPWDK;AGS(1)PELVVLDPPWDK;AGS(1)PELVVLDPPWDK 71.153 0.00034909 11627100.0 78060.0 65189.0 81516.0 87862.0 89267.0 72819.0 79338.0 87637.0 70649.0 78785.0 True False 73721.73769893865 70188.78668432769 76271.34930791012 75895.04402959606 78052.48140289464 82849.15626493325 83027.37420526448 87892.00916091373 84780.77409799221 76510.27234198658 0.9635534607616648 0.9173772950460425 0.9968772424046731 0.9919588795914807 1.020156888920937 1.0828501027236324 1.0851794362219451 1.1487608979883501 1.108096618961674 1.0 16.223365837968252 -6.369909661087417 1.0650407448323633 1.0997489388780142 0.9483996652578346 0.6645719629096382 0.039561159236572475 0.27540107421562776 0.6593825173648242 0.017701512166410003 0.023972514731339954 4.2666826213086303e-07 6.369909661087417 -0.15134927362017958 (ac)AGS(ph)QDIFDAIVMADER ddPTM_A459_Selumetinib_30min_R1 2 AGSQDIFDAIVMADER 16 0 F5H8D9;F5H179;A6YPU5;F5H6T8;F5GZY6;B4DFA5;Q8WV07 F5H8D9 ORAOV1 Oral cancer-overexpressed protein 1 1 AGS(1)QDIFDAIVMADER;AGS(1)QDIFDAIVMADER 70.563 0.012535 1090880.0 0.0 164.92 0.0 66.717 151.33 0.0 137.85 0.0 0.0 71.52600000000002 True False 0.0 145.61108973077208 0.0 55.06612838319701 137.64222821948152 0.0 127.45186351632832 0.0 0.0 80.7070588222394 0.0 1.8041927416966892 0.0 0.6822963094774945 1.70545464334965 0.0 1.579191032063828 0.0 0.0 1.0 6.334622955286085 (ac)AHS(ph)PVAVQVPGMQNNIADPEELFTK ddPTM_A459_Selumetinib_30min_R1 1 AHSPVAVQVPGMQNNIADPEELFTK 25 0 Q8NBY1;B4E0Y9;Q9P289-3;Q9P289 Q8NBY1 STK26 Serine/threonine-protein kinase 26 1 AHS(1)PVAVQVPGMQNNIADPEELFTK 66.294 9.4907e-09 8352200.0 1252.4 2016.2 1987.9 2045.7 2017.7 1462.6 1554.4 1619.2 987.27 1287.3 True False 1281.5784832538152 1780.1423666940498 1717.9540987530768 1688.456897544945 1835.1993912538678 1447.887571934547 1437.1503565453813 1576.2535560971528 1675.3250826521526 1452.5374943638499 0.8823032026550836 1.2255397011102127 1.182726163984819 1.1624188044002388 1.2634437309706816 0.9967987591044324 0.9894067190153962 1.0851723705676082 1.1533782013564298 1.0 10.504359689073048 -6.785394567732785 24.993368749394605 1.0468029572458908 1.1511100505803311 0.17510600407824917 0.10599954131130616 408.25972467140093 425950.1784113349 0.03739684685535636 0.032997689096946455 1.639099931978752e-07 6.785394567732785 0.10430709333444033 (ac)AHS(ph)PVQSGLPGMQNLK ddPTM_A459_Selumetinib_30min_R1 8 AHSPVQSGLPGMQNLK 16 0 B4DR80;Q9Y6E0-2 B4DR80 STK24 1 AHS(0.998)PVQS(0.002)GLPGMQNLK;AHS(0.965)PVQS(0.035)GLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(0.828)PVQS(0.172)GLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(1)PVQSGLPGMQNLK 172.27 1.2761e-52 250640200.0 14325.129999999997 15651.029999999999 16352.99 18781.760000000002 16740.74 13955.98 15648.82 14567.369999999999 8060.629999999999 12282.670000000002 True False 14658.877657149256 13818.600131633546 14132.343778544233 15501.878193299975 15226.543022817705 13815.595512215978 14468.416908462734 14180.996026113487 13678.300384877919 13859.27033783735 1.0576947631311362 0.9970654872000895 1.0197033057333014 1.1185205148194652 1.0986540165283845 0.9968486922791213 1.043952282896333 1.023213753713844 0.986942317412962 1.0 13.758563684088514 -7.817027344263291 1.2107628202037355 0.9936581776718241 1.050855054571342 0.2541622521286031 0.037064467727148984 0.7750230047482113 2.054009539478354 0.03524302401517681 0.013326431878000056 1.5239567986572173e-08 7.817027344263291 0.05719687689951791 (ac)AHS(ph)PVQSGLPGMQNLK ddPTM_A459_Selumetinib_30min_R2 5 AHSPVQSGLPGMQNLK 16 0 B4DR80;Q9Y6E0-2 B4DR80 STK24 1 AHS(0.999)PVQS(0.001)GLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(1)PVQSGLPGMQNLK;AHS(1)PVQSGLPGMQNLK 181.26 1.8643999999999997e-62 183611000.0 113988.4 105700.0 128162.0 132772.0 134840.0 98033.7 95198.2 107216.1 95730.4 106680.3 True False 107653.3810597193 113806.85012093182 119916.1964522347 114688.22455552452 117900.19371510547 111536.95231367605 99625.10493165469 107528.08110041915 114879.15493086148 103600.16255029326 1.0391236694002133 1.0985199957160654 1.1574904276238054 1.1070274576050834 1.1380309722764208 1.0766098195987852 0.9616307781688194 1.0379142122312701 1.1088704120043515 1.0 16.660666741074387 -7.006608916175862 23.93433025766712 1.0286714959251744 1.109912825597215 0.420635521538389 0.04476303319164394 174.1636322437827 630739.8799596459 0.016553097061087586 0.014063346140678175 9.84897610575511e-08 7.006608916175862 0.08124132967204067 (ac)AKS(ph)PENSTLEEILGQYQR ddPTM_A459_Selumetinib_30min_R1 2 AKSPENSTLEEILGQYQR 18 1 Q86SQ7-2;Q86SQ7-3;Q86SQ7-4;Q86SQ7 Q86SQ7-2 SDCCAG8 Serologically defined colon cancer antigen 8 1 AKS(1)PENSTLEEILGQYQR;AKS(0.999)PENS(0.001)TLEEILGQYQR 82.705 0.00083423 7191400.0 1302.92 1435.88 2126.31 2023.94 1807.25 1648.2 1772.21 1708.4699999999998 881.9 1177.1 True False 1333.2755009590078 1267.766502077498 1837.5687809847846 1670.4968730591577 1643.7845565959026 1631.620604445864 1638.530772885544 1663.1558257073257 1496.5198885724603 1328.1922509249498 1.0038271944671548 0.95450526924444 1.383511144343077 1.257722194882426 1.237610410278463 1.2284521335744938 1.233654820485871 1.2521950979228407 1.1267343922013455 1.0 10.375248271242771 -5.240833584761371 24.822572087999525 1.2274741175082458 0.9791661628121826 0.49605358285361945 0.09440595425691307 542.4201283672759 653418.5865312812 0.022591281341550657 0.059616970573263636 5.743364973205274e-06 5.240833584761371 -0.24830795469606315 (ac)ALVT(ph)VSRSPPGSGASTPVGPWDQAVQR ddPTM_A459_Selumetinib_30min_R2 1 ALVTVSRSPPGSGASTPVGPWDQAVQR 27 1 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-2 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 ALVT(0.728)VS(0.194)RS(0.06)PPGS(0.007)GAS(0.008)T(0.003)PVGPWDQAVQR 57.21 8.509e-06 2471100.0 3118.4 4485.1 2646.4 3522.8 3285.1 2484.1 3077.0 4000.7 2519.2 3349.8 True False 2945.091811944274 4829.092748130476 2476.133505182459 3042.988562831039 2872.396368833379 2826.2622265853743 3220.08659695983 4012.3413746484625 3023.1103923291503 3253.082570174362 0.9053234119988599 1.484466700109503 0.7611652799362362 0.935416945985462 0.8829767787540115 0.8687951091367132 0.9898570133088372 1.2333967208318986 0.9293063815982742 1.0 11.667591726183234 -5.2762196790279345 24.998846327079633 0.9540423407890817 1.1948951166231412 0.24217111856791984 0.17309389356156357 984.1414814079003 1664539.7341695405 0.04447292360605524 0.09319522899674273 5.293955921639709e-06 5.2762196790279345 0.2408527758340595 (ac)AMVS(ph)EFLK ddPTM_A459_Selumetinib_30min_R1 1 AMVSEFLK 8 0 P04083;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 AMVS(1)EFLK 95.502 0.004403 2264900.0 506.18 577.38 658.35 691.55 698.04 539.92 602.92 699.83 338.08 455.38 True False 517.9730091451746 509.78008118332014 568.9496860576933 570.7837745012498 634.9024052489713 534.4888950081368 557.4412589863233 681.2682350317872 573.6970676137629 513.8324587768271 1.0080581720707251 0.9921134262262185 1.1072669239543025 1.1108363528843521 1.2356214450919467 1.040200722781278 1.0848696875111907 1.3258567523226135 1.1165060863991403 1.0 9.005154217882792 -5.388278555061806 2.407173591950304 1.142806742477381 0.9953938417344258 0.24303955225440554 0.08859813356386058 0.3968651708774777 4.386189221725223 0.024793583890742425 0.06897329974459658 4.0899824544478745e-06 5.388278555061806 -0.1474129007429551 (ac)ANDSGGPGGPS(ph)PSERDR ddPTM_A459_Selumetinib_30min_R1 2 ANDSGGPGGPSPSERDR 17 1 Q9GZT9;Q9GZT9-2;Q9GZT9-3 Q9GZT9 EGLN1 Egl nine homolog 1 1 ANDS(0.001)GGPGGPS(0.863)PS(0.136)ERDR;ANDSGGPGGPS(0.912)PS(0.088)ERDR 73.834 0.0014095999999999998 1784380.0 0.0 129.77 160.23 130.77 61.953 70.582 158.46 0.0 0.0 128.93 True False 0.0 114.57646807156375 138.4716460803891 107.93347435692067 56.34936208869052 69.87200916332846 146.50723462312212 0.0 0.0 145.47942138454994 0.0 0.7875785247227542 0.9518297829516589 0.7419157522741104 0.387335621439823 0.48028792318766356 1.0070650077432968 0.0 0.0 1.0 7.184671282659855 -7.7733274673480075 24.9988308684271 0.2500001115192535 0.6314225524121516 0.09602644412988093 0.3806542447703708 411.08088007502755 864426.8378032173 0.2009110469382494 0.09771834549468562 1.6852818075810468e-08 7.7733274673480075 0.3814224408928981 (ac)AQDQGEKENPMR ddPTM_A459_Selumetinib_30min_R1 1 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 0 68.557 0.0057229 5035700.0 1256.9 1249.8 1469.9 1772.5 1191.0 1158.0 1034.7 1318.2 706.94 1011.6 False True 1286.1833244983409 1103.4728349837433 1270.2956535827489 1462.9661489457962 1083.2742602881278 1146.3515713798745 956.6517459582514 1283.2370538829457 1199.6255471452723 1141.448713818435 1.1267990483740018 0.9667301050192147 1.112880183055521 1.2816748849379347 0.9490345445870285 1.0042952937806888 0.8381031354076427 1.1242178806178622 1.0509675403043044 1.0 10.156650324266746 (ac)AQES(ph)PKNSAAEIPVTSNGEVDDSR ddPTM_A459_Selumetinib_30min_R1 1 AQESPKNSAAEIPVTSNGEVDDSR 24 1 P53367;P53367-2;P53367-3 P53367 ARFIP1 Arfaptin-1 1 AQES(0.954)PKNS(0.046)AAEIPVTSNGEVDDSR 67.418 2.412e-07 5519200.0 406.95 298.09 549.59 728.2 242.23 364.24 366.63 380.9 146.46 509.0 True False 416.43114321314323 263.1894842217186 474.9586966817764 601.0335400069556 220.32033926917993 360.576076303459 338.97480392449364 370.797294662429 248.53192298483128 574.3351080798567 0.7250664940288516 0.4582507329242429 0.8269713796004565 1.0464858086359343 0.3836093879159937 0.6278147918015204 0.5902038707990004 0.6456114025522407 0.432729811373946 1.0 9.165748943566564 -10.702624867039168 4.813118868551044 1.0000404842870718 0.6408581886206302 0.2514785483480213 0.18757967842838816 8.286829464258567e-05 1.4122492466935397e-05 0.18469700174971015 0.04479056320871556 1.9832393598581e-11 10.702624867039168 -0.35918229566644166 (ac)AQQTSPDT(ph)LTVPEVDNPHCPNPWLNEDLVK ddPTM_A459_Selumetinib_30min_R1 1 AQQTSPDTLTVPEVDNPHCPNPWLNEDLVK 30 0 Q08499-6;Q08499-7;Q08499-12 Q08499-6 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 AQQT(0.095)S(0.095)PDT(0.405)LT(0.405)VPEVDNPHCPNPWLNEDLVK 50.294 0.00027931 3364400.0 281.46 237.64 218.38 426.63 341.53 319.4 387.17 411.67 0.0 216.4 True False 288.01747037417664 209.81699832416118 188.72519547547503 352.1270793369509 310.63867180201896 316.1871259919968 357.9654551876447 400.75117430738317 0.0 244.177047914501 1.1795435846002464 0.859282230316868 0.7729030926017153 1.4420973729695052 1.2721862044576344 1.2949092828033135 1.4660077932999946 1.6412319574266736 0.0 1.0 7.931783786430322 -8.257205000785117 24.999590528094274 0.5000000079161541 1.2297290127748994 0.43827224319000146 0.33537344014195974 320.4149743767806 1891745.207422975 0.25016479603103503 0.08704544882514793 5.530889720316606e-09 8.257205000785117 0.7297290048587454 (ac)AQY(ph)GHPSPLGMAAR ddPTM_A459_Selumetinib_30min_R2 2 AQYGHPSPLGMAAR 14 0 Q8TF42 Q8TF42 UBASH3B Ubiquitin-associated and SH3 domain-containing protein B 1 AQY(0.647)GHPS(0.353)PLGMAAR;AQY(0.795)GHPS(0.205)PLGMAAR 89.171 0.027958 0.0 3207.6000000000004 2737.0 3582.3 5408.5 6631.1 2402.21 1215.1 2442.6 1096.9 6662.1 True False 3029.3344330401683 2946.919099157905 3351.8187181133317 4671.852969817099 5798.04193521385 2733.0926224087807 1271.6045576749718 2449.7075616058 1316.3106499467467 6469.747862785427 0.4682306787355923 0.4554921090679359 0.518075632806851 0.722107425034292 0.8961774180667395 0.4224419066050125 0.19654623095736942 0.3786403448110766 0.20345625175260448 1.0 12.659493773665478 -6.97379278191069 24.98204152663064 0.3809681970383426 0.6097272725179848 0.08863839580130106 0.2440533801430361 396.26230842187306 377736.0100324402 0.08432620209831011 0.07436669823402133 1.0622022526047518e-07 6.97379278191069 0.22875907547964214 (ac)AS(ph)AVSPANLPAVLLQPR ddPTM_A459_Selumetinib_30min_R1 2 ASAVSPANLPAVLLQPR 17 0 P51610;A6NEM2;P51610-2;P51610-4;P51610-3 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 AS(0.996)AVS(0.004)PANLPAVLLQPR;AS(0.96)AVS(0.04)PANLPAVLLQPR 119.74 8.315100000000002e-07 14962100.0 534.75 871.24 531.12 338.69 564.74 510.42 467.63 494.41 335.74 636.25 True False 547.2086345576321 769.2348157715127 458.9968212333288 279.5441494987036 513.659366712945 505.28563822427964 432.35629260892694 481.2966407299854 569.7262585206009 717.9188850998206 0.7622151275231426 1.0714787307267408 0.6393435675807708 0.3893812452918484 0.7154838483480275 0.7038199561417359 0.602235575052203 0.670405321156951 0.793580264212419 1.0 9.487677038453926 -8.617258634131863 3.129483077632142 0.9997557187607669 0.693472489537943 0.2554751400566482 0.15895560277985626 0.6094180846778191 13.873323982435725 0.16610470831160726 0.044090907877302445 2.4140227903069565e-09 8.617258634131863 -0.3062832292228238 (ac)AS(ph)AVSPANLPAVLLQPR ddPTM_A459_Selumetinib_30min_R2 1 ASAVSPANLPAVLLQPR 17 0 P51610;A6NEM2;P51610-2;P51610-4;P51610-3 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 AS(0.517)AVS(0.483)PANLPAVLLQPR 110.84 0.00041329 10239000.0 1672.8 0.0 1258.9 1949.0 0.0 1453.5 1068.2 0.0 0.0 740.89 True False 1579.8324727489685 0.0 1177.9037445866827 1683.542837787468 0.0 1653.7064314406991 1117.8734165981448 0.0 0.0 719.4985806365997 2.1957409163353185 0.0 1.637117537528002 2.3398834731513976 0.0 2.298415140690797 1.5536839775404003 0.0 0.0 1.0 9.490848030721454 -7.758576109004611 24.997201989093405 0.24999986401249658 1.398074671377508 0.2633262598544742 0.8373751008802941 94.8888434139611 828431.9319308489 0.4020856597058294 0.2189587363806582 1.743507785381317e-08 7.758576109004611 1.1480748073650116 (ac)AS(ph)CASIDIEDATQHLR ddPTM_A459_Selumetinib_30min_R2 1 ASCASIDIEDATQHLR 16 0 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 AS(0.809)CAS(0.191)IDIEDATQHLR 124.42 1.0906e-06 3655400.0 0.0 0.0 657.78 0.0 0.0 0.0 823.13 0.0 0.0 0.0 True False 0.0 0.0 615.4591509367135 0.0 0.0 0.0 861.4071760011516 0.0 0.0 0.0 0.0 (ac)AS(ph)EAPSPPRS(ph)PPPPTSPEPELAQLR ddPTM_A459_Selumetinib_30min_R1 2 ASEAPSPPRSPPPPTSPEPELAQLR 25 1 Q8N302;Q8N302-2;Q8N302-3 Q8N302 AGGF1 Angiogenic factor with G patch and FHA domains 1 2 AS(0.578)EAPS(0.493)PPRS(0.929)PPPPTSPEPELAQLR;AS(0.643)EAPS(0.648)PPRS(0.694)PPPPT(0.01)S(0.005)PEPELAQLR 93.583 6.6191e-08 4443000.0 205.835 394.78999999999996 118.08 138.29 317.97 167.29 60.929 152.64 130.12 160.85 True False 210.6305550148109 348.5678032671081 102.04538456701208 114.14024752480354 289.20966964216325 165.6072144871669 56.33307647578067 148.5914913554034 220.80413641121288 181.49666431167972 1.1605202542626363 1.9205190607168474 0.5622438569547045 0.6288834450907226 1.5934709915412586 0.9124532129294329 0.31038078131861024 0.8187009492374522 1.2165740745076803 1.0 7.503799223256245 -6.987515470158705 24.963500014587492 0.7913215404186951 1.160724199399256 0.12009335796990395 0.431512622093682 480.55100206087565 960884.099623388 0.15908149616127454 0.14021008535830812 1.029163866328168e-07 6.987515470158705 0.369402658980561 (ac)AS(ph)EDNRVPSPPPTGDDGGGGGR ddPTM_A459_Selumetinib_30min_R1 1 ASEDNRVPSPPPTGDDGGGGGR 22 1 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 AS(0.649)EDNRVPS(0.34)PPPT(0.011)GDDGGGGGR 81.789 0.00015465 19870000.0 663.28 801.33 781.37 967.96 1068.5 924.17 906.58 615.34 419.38 555.34 True False 678.7331334817882 707.50991107179 675.2642457581832 798.9239568595618 971.8543636589968 914.8736888792222 838.1959407082545 599.0191842939857 711.6572296966988 626.6232984696812 1.0831597470751053 1.129083314967138 1.0776239048361134 1.274966888097949 1.5509387634204275 1.4600058617569704 1.3376392846472018 0.9559478330232704 1.135701834634436 1.0 9.291454601299503 -7.758730837912654 24.999537127705423 1.0343686051863479 1.2781873974976155 0.350425049345114 0.15135692942980397 91.59093294679619 845400.7320519676 0.0869322253038201 0.04725415510391218 1.7428867252108545e-08 7.758730837912654 0.24381879231126757 (ac)AS(ph)EELQKDLEEVK ddPTM_A459_Selumetinib_30min_R1 1 ASEELQKDLEEVK 13 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 1 AS(1)EELQKDLEEVK 79.65899999999998 0.0062198 4647900.0 732.81 1010.2 1235.0 1470.4 844.94 1133.7 903.81 892.6 521.03 808.08 True False 749.8830471999595 891.9253143707613 1067.2937833694093 1213.6222428264591 768.5153261862731 1122.2960073172403 835.6348840383945 868.9253484265798 884.1498554744412 911.804939365758 0.8224160835557333 0.9781975024078892 1.1705286265632733 1.331010823072139 0.8428505846007419 1.2308509845295397 0.9164623352661957 0.9529728463973833 0.9696699560428426 1.0 9.832581414264947 (ac)AS(ph)ESDTEEFYDAPEDVHLGGGYPVGSPGK ddPTM_A459_Selumetinib_30min_R1 2 ASESDTEEFYDAPEDVHLGGGYPVGSPGK 29 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 AS(0.455)ES(0.455)DT(0.052)EEFY(0.038)DAPEDVHLGGGYPVGSPGK;AS(0.435)ES(0.435)DT(0.111)EEFY(0.02)DAPEDVHLGGGYPVGSPGK 102.46 2.2286e-13 18829200.0 5231.6 5590.0 5850.1 6454.4 6252.0 5248.799999999999 5144.0 4719.0 3313.1000000000004 4553.4 True False 5353.486101078462 4935.520201279503 5055.688552299098 5327.260204093511 5686.507703880247 5196.001837529091 4755.98393854184 4593.836790527706 5622.088720749995 5137.8732438719435 1.0419653905365776 0.9606154077791251 0.9840041418556075 1.0368609639109827 1.1067824046968602 1.011313746154886 0.9256717152791593 0.8941125194178113 1.094244340779638 1.0 12.326955582706749 -7.020614250392281 24.28518171283825 0.9695131105318627 1.0245130730289786 0.1130914337403528 0.060863641991402435 1085.9722609059374 1279356.86967332 0.02375897719367763 0.01863823469233407 9.536428338270403e-08 7.020614250392281 0.05499996249711592 (ac)AS(ph)GVAVSDGVIK ddPTM_A459_Selumetinib_30min_R1 23 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 1 AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(0.999)GVAVS(0.001)DGVIK;AS(1)GVAVSDGVIK;AS(0.997)GVAVS(0.003)DGVIK;AS(1)GVAVSDGVIK;AS(0.995)GVAVS(0.005)DGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK 111.65 8.2342e-06 6802536616.0 144012.748 231265.336 182553.90000000002 211769.63 156537.62699999998 191856.2 184492.09999999998 151940.926 105291.12000000001 134194.8 True False 147367.96482837238 204188.68294878234 157764.0830767943 174788.03952878775 142378.82627681282 189926.30081949176 170575.71236155817 147910.9590687959 178671.3404808593 151420.00974804498 0.9732396997833048 1.3484920737261983 1.0418971927112246 1.1543259032912887 0.9402906954881576 1.2543012058678324 1.1265070755535367 0.9768257135560355 1.1799717935440575 1.0 17.208196340637457 -14.522878739055422 0.15398261802302338 0.5922709873875971 1.1454188810367156 0.05727407380981442 0.12499441205495143 384.8430587141215 3.4618208829248105 47.94122769794385 0.5612052797512364 3.0000000430001956e-15 14.522878739055422 0.5531478936491185 (ac)AS(ph)GVAVSDGVIK ddPTM_A459_Selumetinib_30min_R2 12 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 1 AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK 114.86 1.9602e-08 2302811000.0 4892770.0 4358422.0 4455612.0 4836683.0 4524893.0 4686198.0 3228730.0 3431150.0 3083586.0 4564686.0 True False 4620849.43071017 4692698.952864448 4168942.7748235473 4177918.4316564384 3956435.4882833348 5331679.237430031 3378872.3426071224 3441134.078442542 3700389.3625915656 4432891.6547014555 1.0424007150748587 1.0586089889852022 0.9404567265707999 0.9424815125416846 0.8925179761808979 1.202754240964887 0.7622275944920835 0.776272994354132 0.8347574564938871 1.0 22.07981667102539 -7.296667766106136 24.999957350309835 0.8246705775852403 1.003260347732235 0.3989314287341894 0.10068721076985143 601.7311233149604 427018.3949779861 0.04143852479157931 0.027938791694775148 5.050475095536362e-08 7.296667766106136 0.17858977014699473 (ac)AS(ph)GVQVADEVCR ddPTM_A459_Selumetinib_30min_R1 4 ASGVQVADEVCR 12 0 P60981;F6RFD5 P60981 DSTN Destrin 1 AS(1)GVQVADEVCR;AS(1)GVQVADEVCR;AS(1)GVQVADEVCR;AS(1)GVQVADEVCR 114.4 0.00041344 297220800.0 1528.0900000000001 1774.21 1417.65 1166.21 1909.85 1053.98 1521.429 1469.5300000000002 484.09999999999997 1228.32 True False 1563.6915238544584 1566.4846683921492 1225.1409165940443 962.553315972963 1737.1044047114033 1043.3779181372718 1406.666385620485 1430.5532906938297 821.4823427349223 1385.986836849999 1.1282152775767609 1.1302305525154746 0.8839484503175244 0.6944895076785906 1.2533339845127294 0.7528050702910054 1.0149204510610543 1.0321550339865557 0.5927057320413994 1.0 10.436697840476747 -5.257544472859301 23.181961639941367 0.9078849485412512 1.129222996872699 0.20119838604134033 0.18006115294636918 186.076845313636 1107466.953625959 0.04435679957386587 0.10819499114619428 5.526568115838382e-06 5.257544472859301 0.22133804833144777 (ac)AS(ph)GVQVADEVCR ddPTM_A459_Selumetinib_30min_R2 2 ASGVQVADEVCR 12 0 P60981;F6RFD5 P60981 DSTN Destrin 1 AS(1)GVQVADEVCR;AS(1)GVQVADEVCR 111.06 0.00045876 369600000.0 41040.0 26954.3 42032.9 41455.1 53568.8 25610.0 20409.0 25911.0 27255.0 33107.0 True False 38759.16109613682 29021.608138265205 39328.54897596126 35808.84386596374 46839.008432851806 29137.54503556677 21358.05893966628 25986.396720203044 32706.761568327624 32151.11488768363 1.2055308573757915 0.9026625745218786 1.223240597203276 1.1137667851039685 1.4568393225702658 0.9062685738070224 0.6643022804738903 0.8082580280958732 1.0172823456538003 1.0 14.972581145564396 -6.974429164840573 24.862081355422482 0.8463111519497699 1.1654450560025575 0.4733871693635354 0.15780043457599194 180.68420064890995 175675.5362265282 0.05595262914687381 0.04934397166730646 1.0606469200012675e-07 6.974429164840573 0.31913390405278763 (ac)AS(ph)GVTVNDEVIK ddPTM_A459_Selumetinib_30min_R1 4 ASGVTVNDEVIK 12 0 Q9Y281;G3V2U0;F8WDN3 Q9Y281 CFL2 Cofilin-2 1 AS(0.531)GVT(0.469)VNDEVIK;AS(1)GVTVNDEVIK;AS(0.981)GVT(0.019)VNDEVIK;AS(1)GVTVNDEVIK 160.59 4.4275e-25 362358200.0 14933.14 21271.8 18246.16 21151.4 14857.66 17543.379999999997 18053.699999999997 14299.619999999999 9754.35 13263.44 True False 15281.053107167752 18781.287767008464 15768.431690982667 17457.70505095184 13513.787276332918 17366.90952531456 16691.89487388274 13920.347625888062 16552.41952046352 14965.931720846167 1.0210559150074598 1.2549360853255702 1.0536217848046634 1.1664963716649104 0.9029699940104267 1.160429557561328 1.1153261410803086 0.9301357166088294 1.1060066175103234 1.0 13.86939447777747 (ac)AS(ph)GVTVNDEVIK ddPTM_A459_Selumetinib_30min_R2 2 ASGVTVNDEVIK 12 0 Q9Y281;G3V2U0;F8WDN3 Q9Y281 CFL2 Cofilin-2 1 AS(1)GVTVNDEVIK;AS(1)GVTVNDEVIK 122.94 0.00041393 80424000.0 222612.0 229660.0 207767.0 211189.0 204271.0 198599.0 160639.0 158179.0 161725.0 226177.0 True False 210240.11622644265 247274.18352670968 194399.4974196056 182424.69387865494 178608.65077408997 225954.20954777545 168109.03180013967 158639.27470205678 194074.51897405196 219646.68233157962 0.9571741034042264 1.1257815547308083 0.8850554688831551 0.8305369875938567 0.813163435377829 1.0287166969664214 0.7653611245826218 0.7222475341675055 0.8835759179875806 1.0 17.744825182745586 -5.394809761020685 5.7675207196855 0.8529688123728835 1.039787632375528 0.33956022646900297 0.09731180088665763 0.22694853163375772 9.596163981093039 0.0255253048314351 0.05410903406227105 4.028934797166076e-06 5.394809761020685 0.1868188200026445 (ac)AS(ph)PGHSDLGEVAPEIK ddPTM_A459_Selumetinib_30min_R1 1 ASPGHSDLGEVAPEIK 16 0 F8WDN0;S4R325;Q8TCY9-2 F8WDN0 URGCP;URGCP-MRPS24 Up-regulator of cell proliferation 1 AS(1)PGHSDLGEVAPEIK 101.56 6.6788e-16 17935000.0 4944.4 4977.5 5859.9 6336.8 5034.8 5247.8 4523.2 4788.8 2537.9 4315.6 True False 5059.594899872381 4394.731986023031 5064.157766126643 5230.1968364681115 4579.403228966136 5195.011896621163 4182.01138235079 4661.785467785349 4306.630939117868 4869.549297503793 1.0390273495056324 0.9024925547577552 1.0399643697462122 1.0740617903076146 0.9404162375589071 1.0668362879669802 0.8588087165468381 0.9573340740538459 0.8844003163343093 1.0 12.249572534106008 -7.260400660491847 24.99993836221946 0.9215802845604116 1.0066059407795531 0.3115126930830432 0.061897660665917086 117.48892089740188 2827779.2915924927 0.02374751369797417 0.017291790015780368 5.490341260322329e-08 7.260400660491847 0.08502565621914149 (ac)AS(ph)PGHSDLGEVAPEIK ddPTM_A459_Selumetinib_30min_R2 4 ASPGHSDLGEVAPEIK 16 0 F8WDN0;S4R325;Q8TCY9-2 F8WDN0 URGCP;URGCP-MRPS24 Up-regulator of cell proliferation 1 AS(0.995)PGHS(0.005)DLGEVAPEIK;AS(0.959)PGHS(0.041)DLGEVAPEIK;AS(0.999)PGHS(0.001)DLGEVAPEIK;AS(1)PGHSDLGEVAPEIK 102.62 2.8179000000000007e-15 19342500.0 155510.0 134023.0 161868.0 177865.0 169729.0 140647.0 134658.0 149659.0 121534.0 158971.0 True False 146867.3767558538 144302.13314813314 151453.58910855307 153639.48016576076 148406.12562348787 160019.84758365343 140919.86381976499 150094.48291261867 145844.19594368472 154381.09417373856 0.9513300675960431 0.9347137609073901 0.9810371530215293 0.9951962122567729 0.9612972781270319 1.0365248960055244 0.9128051888346868 0.9722335737801172 0.9447024373305288 1.0 17.236136562458476 -3.090066507993675 7.958344900009092 0.9684258268475585 0.9459422973312523 0.0 0.03414769218307717 0.0 0.0 0.007622043834986212 0.0 0.0008127060485737205 3.090066507993675 -0.022483529516306167 (ac)AS(ph)PGIEVELLGK ddPTM_A459_Selumetinib_30min_R1 2 ASPGIEVELLGK 12 0 Q8TCY9 Q8TCY9 URGCP Up-regulator of cell proliferation 1 AS(1)PGIEVELLGK;AS(1)PGIEVELLGK 90.15 0.00011479 8791100.0 5661.3 6366.9 6428.3 6479.4 5666.2 5178.8 5383.7 4948.9 2709.45 4112.7 True False 5793.19727502781 5621.460388108492 5555.3721681243505 5347.8944234016335 5153.693210448858 5126.705973974178 4977.603174558263 4817.639095707257 4597.738759601604 4640.605106090427 1.2483710944128161 1.2113636604697886 1.1971223668295679 1.1524131662017405 1.110564913977499 1.104749457618314 1.07261942370954 1.0381489020439354 0.9907627678915053 1.0 12.180097220755792 -6.318641856776052 0.4018582732021663 0.9846680558886829 1.2885749686600543 0.9757665062255042 0.013176749644623403 0.2630105592973652 0.07620404003413102 0.013653488126464936 0.033977907529885505 4.801292265107667e-07 6.318641856776052 0.3039069127713714 (ac)AS(ph)PPESDGFSDVRK ddPTM_A459_Selumetinib_30min_R1 4 ASPPESDGFSDVRK 14 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 AS(1)PPESDGFSDVRK;AS(1)PPESDGFSDVRK;AS(1)PPESDGFSDVRK;AS(1)PPESDGFSDVRK 160.77 4.8396e-06 107577600.0 8857.07 8843.54 12459.099999999999 13448.2 11472.9 8989.72 9010.05 8580.34 4903.63 7553.450000000001 True False 9063.422498141863 7808.134225549791 10767.222652937493 11099.724323979044 10435.178220705011 8899.29157881269 8330.414674467132 8352.761510327715 8321.101963035017 8523.008884333585 1.0634064355842254 0.9161241448313132 1.2633123817023197 1.3023246220453673 1.2243537889402234 1.0441490440272523 0.9774030260345655 0.980024968140206 0.9763103706638508 1.0 13.05714712076818 -6.9529541710192175 5.165336746887522 0.9849827245420899 1.1545828521042434 0.3857421040447535 0.10209227942832139 0.2388208715125228 14.40542933255549 0.042163452541159906 0.036556555261187736 1.114412125869352e-07 6.9529541710192175 0.16960012756215348 (ac)AS(ph)PPESDGFSDVRK ddPTM_A459_Selumetinib_30min_R2 3 ASPPESDGFSDVRK 14 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 AS(1)PPESDGFSDVRK;AS(0.991)PPES(0.009)DGFSDVRK;AS(0.999)PPES(0.001)DGFSDVRK 125.68 6.3802e-09 54270700.0 171205.0 177233.0 177973.0 182090.0 189988.0 132009.0 134813.0 127800.0 96481.0 181289.0 True False 161690.1114879166 190826.20120608425 166522.41094235124 157289.0278772293 166120.00892572998 150192.04149161026 141082.0716268917 128171.87684157118 115779.895904378 176054.71552461034 0.9184082971371151 1.0839028119040017 0.9458560109915 0.8934099118477867 0.943570346472818 0.8530986576761996 0.8013535519710071 0.728022969788925 0.6576358693908052 1.0 17.425664343914832 -6.794281158681542 1.1712615033450091 0.769501458536919 0.9785177565266622 0.3853370157472401 0.09453596914369368 0.42418372220767875 1.228408040749272 0.04830829993558422 0.04221276552658212 1.6059012691152965e-07 6.794281158681542 0.2090162979897432 (ac)AS(ph)PSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEER ddPTM_A459_Selumetinib_30min_R1 1 ASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEER 37 1 D6RIS4;P35548 D6RIS4 MSX2 Homeobox protein MSX-2 1 AS(0.408)PS(0.408)KGNDLFS(0.184)PDEEGPAVVAGPGPGPGGAEGAAEER 71.285 1.0392e-06 5867700.0 477.46 296.53 378.06 340.39 221.52 270.1 247.4 54.627 214.16 267.56 True False 488.58388902456613 261.8121297469431 326.72152853493054 280.94727641165576 201.48355511253249 267.3830392311782 228.73841881711735 53.178114506496485 363.4138783724666 301.9039322551012 1.6183422500496782 0.8672034437952219 1.0822036205174668 0.9305850185954597 0.6673763856188663 0.885656033804973 0.7576529961320251 0.17614250370731283 1.2037401290467162 1.0 8.237945737643118 -1.5228788087873024 0.7479425360672582 0.7609500872075543 138.47127699467117 0.41456718050034636 0.27035035526259976 349.84373139079366 1.523477261275854 0.09787163138300296 81150.02203848583 0.029999995613094604 1.5228788087873024 137.7103269074636 (ac)AS(ph)PSSFTYYCPPSSSPVWSEPLYSLRPEHAR ddPTM_A459_Selumetinib_30min_R1 1 ASPSSFTYYCPPSSSPVWSEPLYSLRPEHAR 31 1 P49356 P49356 FNTB Protein farnesyltransferase subunit beta 1 AS(0.868)PS(0.115)S(0.016)FTYYCPPSSSPVWSEPLYSLRPEHAR 121.62 2.3566999999999995e-34 137460000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)AS(ph)PSSFTYYCPPSSSPVWSEPLYSLRPEHAR ddPTM_A459_Selumetinib_30min_R2 2 ASPSSFTYYCPPSSSPVWSEPLYSLRPEHAR 31 1 P49356 P49356 FNTB Protein farnesyltransferase subunit beta 1 AS(0.319)PS(0.319)S(0.319)FT(0.019)Y(0.017)Y(0.006)CPPS(0.001)SSPVWSEPLYSLRPEHAR;AS(0.325)PS(0.325)S(0.325)FT(0.018)Y(0.004)Y(0.001)CPPSSSPVWSEPLYSLRPEHAR 68.23100000000001 1.0496e-11 9127100.0 1831.98 2988.0 695.09 4302.91 2611.1 1874.51 1573.51 786.39 852.2 678.28 True False 1730.1658855969952 3217.1699920656997 650.3686661567701 3716.846235066228 2283.07027446983 2132.7067373924356 1646.681332850913 788.6782647061272 1022.6638124574866 658.6962940169163 2.6266519203348695 4.884147704014679 0.9873574089670947 5.642731360153627 3.466043904007751 3.237769449690671 2.499909818543208 1.1973321724592436 1.552557410367369 1.0 9.36346962297384 -7.512185753056734 1.8972800224529036 1.214692663307212 3.554981826476096 0.41739733257134637 1.1762624796451195 0.33670240530634177 2.381570712806351 0.6852907783400282 0.3489015310784827 3.074781411871937e-08 7.512185753056734 2.340289163168884 (ac)AS(ph)PTDGTDLEASLLSFEK ddPTM_A459_Selumetinib_30min_R1 4 ASPTDGTDLEASLLSFEK 18 0 G3V5T8 G3V5T8 LIN52 1 AS(0.873)PT(0.126)DGT(0.001)DLEASLLSFEK;AS(0.99)PT(0.01)DGTDLEASLLSFEK;AS(0.999)PT(0.001)DGTDLEASLLSFEK;AS(0.904)PT(0.096)DGTDLEASLLSFEK 194.24 3.710099999999998e-164 52557530.0 13198.289999999999 16345.310000000001 15380.65 16959.530000000002 15357.939999999999 14684.210000000001 15528.09 13385.0 9141.33 11705.36 True False 13505.78447759821 14431.593506471536 13292.042209862922 13997.866455306461 13968.81703866453 14536.500179595918 14356.793669563023 13029.986319392528 15512.169353672865 13207.856975861749 1.0225568388786268 1.092652163999523 1.0063738753497276 1.0598136004113694 1.0576141961707708 1.100594911510804 1.0869888806186374 0.986532966188664 1.1744652733613337 1.0 13.689108782462306 -6.2130634800030995 3.0611017811884302 1.0700824450572768 1.0448037009713063 0.04419228962592825 0.053378753373800415 0.9714926678002894 18.23159394648942 0.01596373402226115 0.020621786522769033 6.122608921672175e-07 6.2130634800030995 -0.025278744085970528 (ac)ASAVS(ph)PANLPAVLLQPR ddPTM_A459_Selumetinib_30min_R1 1 ASAVSPANLPAVLLQPR 17 0 P51610;A6NEM2;P51610-2;P51610-4;P51610-3 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 AS(0.004)AVS(0.996)PANLPAVLLQPR 164.93 2.7242e-16 7612600.0 67.567 126.28 0.0 231.64 125.52 0.0 0.0 97.275 57.595 0.0 True False 69.14117963750444 111.49507889402072 0.0 191.18842242132823 114.1667381623559 0.0 0.0 94.69495100626884 97.73450842763454 0.0 0.0 (ac)ASCAS(ph)IDIEDATQHLR ddPTM_A459_Selumetinib_30min_R1 1 ASCASIDIEDATQHLR 16 0 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 AS(0.017)CAS(0.983)IDIEDATQHLR 123.68 1.0601e-06 7825700.0 0.0 0.0 64.806 59.115 65.889 0.0 161.06 0.0 0.0 0.0 True False 0.0 0.0 56.005701153876885 48.79167497598351 59.92935158364777 0.0 148.9111145298501 0.0 0.0 0.0 0.0 (ac)ASCAS(ph)IDIEDATQHLR ddPTM_A459_Selumetinib_30min_R2 1 ASCASIDIEDATQHLR 16 0 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 AS(0.004)CAS(0.996)IDIEDATQHLR 150.12 4.423e-08 3680700.0 623.8 691.07 822.84 578.38 717.44 0.0 0.0 570.48 0.0 959.01 True False 589.131693269253 744.0728468597194 769.8993702404529 499.60364623884897 627.3087732050226 0.0 0.0 572.1400023519518 0.0 931.3208894927797 0.6325764834826251 0.7989435813739343 0.8266746498725687 0.5364463010283657 0.6735688850989592 0.0 0.0 0.6143317612724798 0.0 1.0 9.863134528252738 -6.66539903479439 8.843816023674416 0.27912022213060333 0.7006730648190774 0.26585999051922193 0.3038395573270824 0.32942916100331 27.271461425435923 0.0958815736834793 0.09579199146668824 2.160732305546461e-07 6.66539903479439 0.4215528426884741 (ac)ASEDNRVPS(ph)PPPTGDDGGGGGR ddPTM_A459_Selumetinib_30min_R1 1 ASEDNRVPSPPPTGDDGGGGGR 22 1 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 AS(0.348)EDNRVPS(0.649)PPPT(0.003)GDDGGGGGR 81.327 0.00056676 24085000.0 149.07 113.6 184.62 104.88 159.44 130.89 175.11 181.97 114.59 0.0 True False 152.54304096027337 100.29965918879277 159.5496180450692 86.56467684143028 145.01868015141827 129.57336543861123 161.9013117181302 177.14356447813654 194.45086067753525 0.0 0.0 (ac)ASEDNRVPS(ph)PPPTGDDGGGGGR ddPTM_A459_Selumetinib_30min_R2 2 ASEDNRVPSPPPTGDDGGGGGR 22 1 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 AS(0.369)EDNRVPS(0.63)PPPT(0.002)GDDGGGGGR;AS(0.009)EDNRVPS(0.902)PPPT(0.088)GDDGGGGGR 110.25 0.00011328 74150000.0 0.0 0.0 0.0 0.0 1531.4 0.0 1325.1 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 1339.0118411102972 0.0 1386.7197756358375 0.0 0.0 0.0 0.0 (ac)ASEDNRVPSPPPT(ph)GDDGGGGGREETPTEGGALSLKPGLPIR ddPTM_A459_Selumetinib_30min_R1 1 ASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIR 41 3 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 AS(0.196)EDNRVPS(0.217)PPPT(0.569)GDDGGGGGREET(0.016)PT(0.002)EGGALSLKPGLPIR 44.313 2.3387e-05 147370000.0 1692.3 1748.6 1909.5 2140.6 1950.1 1899.3 1577.8 1542.7 790.43 1116.3 True False 1731.7272973574209 1543.8730990979145 1650.2003881327018 1766.7843940385746 1773.713799318118 1880.1947664264228 1458.785275705933 1501.7825846041728 1341.3019792769362 1259.5879786827973 1.3748363168473225 1.2256969145675762 1.3101112554744958 1.4026685106078682 1.408169837547166 1.4927061850753922 1.1581448063925193 1.1922808172356871 1.0648735951573551 1.0 10.298736178450435 -7.771849779001245 1.5537345236188194 1.0417444464421934 1.3595114382363063 0.7230526664365167 0.08048196832253736 0.23772356215513113 1.0762109194336582 0.0684108680255104 0.02652592485959861 1.6910257506063934e-08 7.771849779001245 0.31776699179411283 (ac)ASGEHS(ph)PGSGAAR ddPTM_A459_Selumetinib_30min_R1 7 ASGEHSPGSGAAR 13 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 1 AS(0.003)GEHS(0.952)PGS(0.045)GAAR;ASGEHS(0.826)PGS(0.174)GAAR;AS(0.001)GEHS(0.781)PGS(0.218)GAAR;AS(0.002)GEHS(0.823)PGS(0.175)GAAR;ASGEHS(0.939)PGS(0.061)GAAR;AS(0.004)GEHS(0.778)PGS(0.218)GAAR;ASGEHS(0.937)PGS(0.063)GAAR 116.9 9.9625e-24 38255900.0 1218.8600000000001 1048.75 1530.3799999999999 1747.0900000000001 1606.66 1403.9899999999998 1368.97 1464.12 867.8900000000001 1289.9549999999997 True False 1247.2570665112958 925.9618624493525 1322.562801775609 1441.9935284410224 1461.3378866788623 1389.8671353209238 1265.7074907359297 1425.2867814679846 1472.7459418223755 1455.5332894757394 0.8569072762056432 0.636166736373903 0.9086448323363154 0.990697731798636 1.0039879522131807 0.9548851581550103 0.8695833340863114 0.9792196384469852 1.0118256672458765 1.0 10.507332120352482 -5.446490075368804 5.698490404595571 0.9671537081116416 0.7483239505594551 0.6690553471533798 0.06270440008588292 0.12132531727735667 6.816254333489075 0.01612244857585857 0.03389873959705843 3.576925745839056e-06 5.446490075368804 -0.21882975755218648 (ac)ASGEHS(ph)PGSGAAR ddPTM_A459_Selumetinib_30min_R2 6 ASGEHSPGSGAAR 13 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 1 AS(0.414)GEHS(0.571)PGS(0.015)GAAR;AS(0.037)GEHS(0.951)PGS(0.012)GAAR;AS(0.015)GEHS(0.982)PGS(0.003)GAAR;AS(0.476)GEHS(0.506)PGS(0.019)GAAR;ASGEHS(0.999)PGS(0.001)GAAR;AS(0.007)GEHS(0.986)PGS(0.007)GAAR 131.08 1.226e-29 374593400.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)ASGEHSPGSGAAR ddPTM_A459_Selumetinib_30min_R2 1 ASGEHSPGSGAAR 13 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 91.549 0.004679600000000001 264010.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)ASGVAVSDGVIK ddPTM_A459_Selumetinib_30min_R1 3 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 0 ;; 91.087 0.0054996 16714400.0 12275.4 16520.5 15356.600000000002 16888.100000000002 13756.300000000001 15729.300000000001 15581.099999999999 12286.399999999998 8556.7 11352.2 False True 12561.392936229555 14586.272179827909 13271.258067765728 13938.9103638993 12512.045093872022 15571.077523061727 14405.805082584415 11960.52476014824 14520.09494335863 12809.365449792043 0.9806413116610304 1.1387193407043215 1.0360589772993933 1.0881811763849392 0.9767888302441361 1.215601005693418 1.1246306570805418 0.9337328072205494 1.1335530241737588 1.0 13.644911388787719 -13.29697369532616 0.6456788535205563 0.012269530145933138 1.0706749688543884 0.05851377067135077 0.0834969377425555 8890.454217013534 118.1867395691756 12581.190440089382 0.030864702821309962 5.046918651931361e-14 13.29697369532616 1.0584054387084552 (ac)ASLEVSRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ASLEVSRSPR 10 1 Q5QPJ9;Q5QPK2;O60762 Q5QPJ9 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 ASLEVSRS(1)PR;ASLEVS(0.075)RS(0.925)PR 120.03 0.00060795 372320000.0 259.38 472.64 527.522 525.11 409.38 511.034 435.722 191.69 212.44 350.53 True False 265.4230493343778 417.30308907562505 455.8874098709293 433.40939603550225 372.3516512819092 505.8934619417473 402.855138738205 186.60575850312688 360.4951639962962 395.5239399513401 0.6710669633980484 1.055064047771582 1.1526164760773152 1.0957854942707719 0.9414136887079915 1.2790463758122597 1.0185354109988054 0.4717938401556283 0.9114370271509903 1.0 8.62762120938761 -7.5609531928177525 24.997341187365603 0.7640017123615978 1.0469768282230218 0.22824089868420439 0.1956357090144008 200.96499982587773 131939.1616498021 0.08929483571880822 0.051554487149316715 2.7481903302800173e-08 7.5609531928177525 0.2829751158614241 (ac)ASLEVSRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ASLEVSRSPR 10 1 Q5QPJ9;Q5QPK2;O60762 Q5QPJ9 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 ASLEVS(0.214)RS(0.786)PR;ASLEVS(0.092)RS(0.908)PR 92.112 0.00065285 218640000.0 9589.8 1927.0 6928.6 5707.3 6938.6 8520.9 6201.4 7719.1 3492.6 5373.700000000001 True False 9056.837307011032 2074.7947037184076 6482.8214192892965 4929.95589435835 6066.911036128967 9694.576629971147 6489.777387840981 7741.561303034201 4191.2175913975825 5218.547318450644 1.735509281479497 0.3975808931314629 1.2422655240412783 0.9446988967462356 1.1625670260148562 1.857715574542191 1.2435984560101216 1.4834705581116827 0.8031387540703436 1.0 12.349432545836608 -6.5287565972658745 24.912863068649862 1.32839560235076 1.0442046943996728 0.04057555042512484 0.40500749717683737 356.7541264133151 1512063.1236290722 0.12702617283485648 0.1273760896709942 2.959670765586771e-07 6.5287565972658745 -0.28419090795108715 (ac)ASPS(ph)RQPPPGGSGLLQGSR ddPTM_A459_Selumetinib_30min_R1 1 ASPSRQPPPGGSGLLQGSR 19 1 Q96S90 Q96S90 LYSMD1 LysM and putative peptidoglycan-binding domain-containing protein 1 1 AS(0.168)PS(0.832)RQPPPGGSGLLQGSR 99.732 2.9360000000000004e-12 7787900.0 697.67 1091.3 776.44 905.63 1047.8 665.29 1129.1 772.89 417.49 673.54 True False 713.924353570496 963.5300886683946 671.0037126796313 747.4787212805539 953.0266750041146 658.5977866349891 1043.931077956375 752.3904464994614 708.450037736837 759.9954198351804 0.9393798106379696 1.2678103887485987 0.8829049428023544 0.9835305605429293 1.2539900243225106 0.866581257526287 1.3736018016829252 0.989993395832085 0.9321767200787577 1.0 9.56984691385597 -7.977584991323019 24.9970279275697 0.9644201052717619 1.082921708783754 0.08364505541249578 0.16356694292184343 531.1639692594199 592349.3552261427 0.08500112289591716 0.040829018404229235 1.0529676014649547e-08 7.977584991323019 0.11850160351199202 (ac)ASPS(ph)SFTYYCPPSSSPVWSEPLYSLRPEHAR ddPTM_A459_Selumetinib_30min_R2 1 ASPSSFTYYCPPSSSPVWSEPLYSLRPEHAR 31 1 P49356 P49356 FNTB Protein farnesyltransferase subunit beta 1 AS(0.126)PS(0.407)S(0.407)FT(0.041)Y(0.013)Y(0.005)CPPSSSPVWSEPLYSLRPEHAR 46.106 0.00023093 7607800.0 0.0 488.45 724.31 654.22 957.06 512.68 0.0 0.0 658.88 775.47 True False 0.0 525.912544385706 677.7086831691004 565.1141074075516 836.8255665750429 583.2970163543299 0.0 0.0 790.6744106453751 753.08016618697 0.0 0.6983486858358394 0.8999157242455421 0.7504036526003112 1.1112038321392748 0.7745483715335462 0.0 0.0 1.049920640784837 1.0 9.556659639272661 (ac)ASPSKGNDLFS(ph)PDEEGPAVVAGPGPGPGGAEGAAEER ddPTM_A459_Selumetinib_30min_R1 1 ASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEER 37 1 D6RIS4;P35548 D6RIS4 MSX2 Homeobox protein MSX-2 1 AS(0.019)PS(0.019)KGNDLFS(0.961)PDEEGPAVVAGPGPGPGGAEGAAEER 116.22 1.7927e-18 4026100.0 205.34 0.0 166.45 139.79 0.0 201.81 186.33 157.56 0.0 68.956 True False 210.12402247791323 0.0 143.84700424440348 115.3783006832908 0.0 199.7799746288192 172.2749780848564 153.3809969729911 0.0 77.80717428831944 2.7005738789495846 0.0 1.848762733772714 1.4828748343404576 0.0 2.567629225147308 2.2141271632160873 1.9712963280818816 0.0 1.0 6.281831281371135 -8.258860123515928 24.97964617985496 0.500000006202379 1.5489728812283177 0.18567529633230884 0.9152874066619558 377.61405779801873 3657223.107049461 0.6804604478337959 0.23020059417321237 5.509851277469324e-09 8.258860123515928 1.0489728750259386 (ac)ASYFDEHDCEPS(ph)DPEQETR ddPTM_A459_Selumetinib_30min_R2 1 ASYFDEHDCEPSDPEQETR 19 0 C9J1C6;Q9P0P0;F8WBU5;C9J391 C9J1C6 RNF181 E3 ubiquitin-protein ligase RNF181 1 AS(0.25)Y(0.188)FDEHDCEPS(0.559)DPEQET(0.003)R 85.054 2.5647e-15 4982900.0 1400.9 1688.7 2719.6 3261.8 5953.4 2560.7 2106.3 899.27 5536.4 1968.5 True False 1323.0435862470292 1818.2178599736772 2544.6238968765933 2817.5372130811534 5205.480667928719 2913.4131812798096 2204.247123554272 901.8867268178377 6643.834699940891 1911.6642902227682 0.6920899202928845 0.9511177612476082 1.3311039547535126 1.473866111059083 2.7230098373193545 1.5240192518009041 1.1530513672447211 0.4717809143742178 3.475419159065151 1.0 10.900613476728173 -5.363982935430713 1.8873152829725783 1.6778011662713344 0.7356247900646248 0.15701470057796962 0.8111533579362888 0.7539445648622095 4.943891796032128 0.2331543088750545 0.8080290767797823 4.32530825971738e-06 5.363982935430713 -0.9421763762067096 (ac)AT(ph)SPQKSPSVPKS(ph)PTPK ddPTM_A459_Selumetinib_30min_R2 1 ATSPQKSPSVPKSPTPK 17 2 Q9NVD7-2;Q9NVD7 Q9NVD7-2 PARVA Alpha-parvin 2 AT(0.69)S(0.154)PQKS(0.154)PS(0.008)VPKS(0.791)PT(0.204)PK 48.899 0.0085464 7434800.0 86485.0 65146.0 78871.0 70907.0 62464.0 48149.0 77712.0 68650.0 45207.0 64240.0 True False 81678.50992688572 70142.48872259447 73796.52572825196 61249.34427860242 54616.71388475486 54781.087696895935 81325.76198340661 68849.76013438078 54249.66318911709 62385.22428443523 1.3092604998017785 1.124344578818716 1.1829167334846593 0.9817924834147593 0.8754751547536141 0.8781099743607641 1.303606148991548 1.1036228678199753 0.8695915388838649 1.0 15.92891675197381 -5.731014368213907 7.2836193808611105 1.0081906012472357 1.1987339420322938 0.3395137053911833 0.12994336170863416 0.25729365386629993 45.16550646712793 0.03823059248171147 0.06514042777232594 1.8577429924405146e-06 5.731014368213907 0.19054334078505808 (ac)AT(ph)TGTPTADRGDAAATDDPAAR ddPTM_A459_Selumetinib_30min_R1 1 ATTGTPTADRGDAAATDDPAAR 22 1 Q86TI2-4;Q86TI2 Q86TI2-4 DPP9 Dipeptidyl peptidase 9 1 AT(0.462)T(0.171)GT(0.183)PT(0.183)ADRGDAAAT(0.001)DDPAAR 70.27199999999999 2.4506e-06 6831600.0 0.0 158.13 116.33 56.06 109.67 0.0 0.0 169.08 0.0 0.0 True False 0.0 139.61606608735738 100.53302495495012 46.2701733765311 99.75036786381114 0.0 0.0 164.59544915075747 0.0 0.0 0.0 (ac)ATAAETS(ph)ASEPEAESK ddPTM_A459_Selumetinib_30min_R2 1 ATAAETSASEPEAESK 16 0 A0A494C0L2;F8W667;A0A499FI31;Q15020-3;Q15020-2;Q15020-4;Q15020 A0A494C0L2 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 1 AT(0.044)AAET(0.183)S(0.77)AS(0.003)EPEAESK 84.759 0.00035867 7651800.0 42305.0 45881.0 47784.0 53236.0 49620.0 30930.0 36673.0 36410.0 33374.0 41525.0 True False 39953.857460333056 49399.925169332775 44709.62946328544 45985.164962777664 43386.29199157172 35190.32674541511 38378.3671661709 36515.94707200002 40049.73254747264 40326.06535509294 0.9907700418703785 1.2250122776506849 1.1087029956826393 1.1403335425326837 1.0758870623635561 0.8726446886286856 0.9517012589308801 0.9055172318563004 0.9931475385662587 1.0 15.299425027306233 -6.615231431246828 5.369374800716654 0.9398813417813532 1.1217408077846596 0.6237482092243892 0.06390957260244884 0.12348356353253313 5.692817631548331 0.02019636185561888 0.02018328468049358 2.4253173229748964e-07 6.615231431246828 0.18185946600330638 (ac)ATAATS(ph)PALKR ddPTM_A459_Selumetinib_30min_R1 1 ATAATSPALKR 11 1 A0A087WVI0;Q8WTW3 A0A087WVI0 COG1 Conserved oligomeric Golgi complex subunit 1 1 AT(0.001)AAT(0.118)S(0.881)PALKR 48.004 0.027478 10693000.0 4557.3 5528.9 5365.8 5755.5 5212.2 4494.0 4437.0 5063.7 2569.1 3685.7 True False 4663.476223037861 4881.573817684123 4637.15383222962 4750.409969115674 4740.757430288651 4448.794440225528 4102.313517750807 4929.394226784304 4359.575060360028 4158.795496758207 1.1213526192074252 1.1737951100238817 1.1150232887970313 1.1422562068316733 1.1399352129682945 1.0697314748208648 0.9864186688065262 1.1852937300299524 1.0482782968670445 1.0 12.021950028779163 -6.772087278656688 6.785458363242405 1.0647668326665813 1.1394896972733297 0.3696946901396738 0.05220739106512553 0.17845459063452696 37.30926056901525 0.017800114971476367 0.016403609291815113 1.6901012437226892e-07 6.772087278656688 0.07472286460674837 (ac)ATDTS(ph)QGELVHPK ddPTM_A459_Selumetinib_30min_R1 1 ATDTSQGELVHPK 13 0 Q5SSJ5;B0QZK9;B0QZK8;Q5SSJ5-5 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 AT(0.114)DT(0.132)S(0.754)QGELVHPK 80.52199999999998 0.0016512 4445800.0 1940.2 3877.1 3059.0 3774.8 2517.0 2624.5 2876.7 2095.7 1280.8 1831.1 True False 1985.4028850279892 3423.1673295851087 2643.604601884231 3115.6020417718455 2289.3377944124436 2598.099912855337 2659.7082029555436 2040.1152282070166 2173.4240540691785 2066.139521424412 0.9609239184676345 1.6567938873872134 1.2794898768800038 1.5079340041973186 1.1080267187542867 1.2574658612910068 1.287283929945796 0.9874043872896568 1.051925115188157 1.0 11.012721963875096 -7.5394739189910345 0.8512225385504376 0.9821028114215097 1.3460387266818992 0.30092058926391074 0.18555556627788272 0.702031159241041 0.9439308132189886 0.15258890335452227 0.07464324069613382 2.8875271807957715e-08 7.5394739189910345 0.3639359152603895 (ac)ATEIGS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 ATEIGSPPR 9 0 Q9C0J8;B9A053;Q9C0J8-3;Q9C0J8-2 Q9C0J8 WDR33 pre-mRNA 3 end processing protein WDR33 1 AT(0.001)EIGS(0.999)PPR 50.108 0.02353 5047600.0 433.27 532.67 532.67 616.92 378.61 339.7 499.56 454.49 385.55 435.39 True False 443.3643480033381 470.30474876843545 460.3363397468693 509.1865030226465 344.36479234902475 336.2829264229219 461.87778700193684 442.4354488084205 654.250190542139 491.27654755773864 0.9024740753602337 0.9573116223569813 0.9370207921288305 1.0364559545004597 0.7009591523571606 0.6845084058961706 0.9401584286855325 0.9005832885935229 1.3317350355814541 1.0 8.940391559476863 -8.162691444370282 7.545401555085531 1.164145221334458 0.8800380344716724 0.44070098678026637 0.1278034797731502 0.24036057525674726 15.839618463644584 0.0904388167836387 0.033819772819938775 6.875567588205785e-09 8.162691444370282 -0.2841071868627857 (ac)ATEIGS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 ATEIGSPPR 9 0 Q9C0J8;B9A053;Q9C0J8-3;Q9C0J8-2 Q9C0J8 WDR33 pre-mRNA 3 end processing protein WDR33 1 AT(0.059)EIGS(0.941)PPR 61.435 0.019353 2359000.0 10928.0 5440.0 10490.0 12165.0 11049.0 7803.8 12264.0 4614.1 10067.0 12090.0 True False 10320.665508250071 5857.230507643042 9815.084820648428 10508.10601420449 9660.925840686738 8878.70261415682 12834.300300654973 4627.526267094625 12080.681295481716 11740.930286407554 0.879033028600662 0.49887277794536805 0.8359716463022804 0.8949977350917157 0.8228415981543785 0.756217982525258 1.0931246492037527 0.39413625276796854 1.0289373159354749 1.0 13.519259103705618 -14.52287874526738 0.1429167558752715 1.7015458173636417 0.7223444680375146 0.09564454601847938 0.20141252193917628 353.35787857631595 3.055657406622067 70.97603970943263 1.1249837256430535 3.0000000000895032e-15 14.52287874526738 -0.9792013493261271 (ac)ATEPPS(ph)PLRVEAPGPPEMR ddPTM_A459_Selumetinib_30min_R1 1 ATEPPSPLRVEAPGPPEMR 19 1 Q8NFU5 Q8NFU5 IPMK Inositol polyphosphate multikinase 1 AT(0.002)EPPS(0.998)PLRVEAPGPPEMR 64.89 0.002195 9311300.0 320.71 470.72 280.45 431.62 378.41 224.08 446.36 290.11 0.0 279.64 True False 328.18191900697155 415.60788356820905 242.36643040157958 356.2456695108518 344.1828823137118 221.8259586483614 412.69070583350253 282.4153403899116 0.0 315.5345179242654 1.0400824644032822 1.3171550494769109 0.7681138405901835 1.129022814538338 1.090793123294113 0.703016456353609 1.307909855784959 0.8950378622528294 0.0 1.0 8.301654027357149 -8.018034045505212 24.257874467660564 0.48250611017991435 1.0456903715888686 0.35809181760721187 0.2909550390066178 487.7856229609663 656122.9637137552 0.17345214228577602 0.06853141555898823 9.593254244840356e-09 8.018034045505212 0.5631842614089542 (ac)ATFVELS(ph)TK ddPTM_A459_Selumetinib_30min_R1 3 ATFVELSTK 9 0 O60218;C9JRZ8 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 1 AT(0.001)FVELS(0.914)T(0.085)K;ATFVELS(0.975)T(0.025)K;ATFVELS(0.932)T(0.068)K 149.96 0.00061802 15605800.0 10756.599999999999 19365.399999999998 18872.5 19464.4 17194.2 15316.4 19237.1 18098.2 6804.599999999999 15779.3 True False 11007.207851299903 17098.08996526978 16309.718159222002 16065.307932039806 15638.98764588256 15162.330922178518 17786.030059121935 17618.176944761282 11546.909211679524 17804.72685839781 0.6182182933128357 0.9603118374829358 0.9160330449848676 0.9023057786737353 0.8783615592792003 0.8515902008924683 0.9989498968771285 0.9895224501268582 0.6485305449228662 1.0 14.119972683093303 -4.7547152448704235 24.99384883276819 0.9054243437829531 0.6182178037630424 0.43160204067841657 0.09875420940558408 217.2443339261768 807432.3049676743 0.02352508184882571 0.22372872532292304 1.7590766148160806e-05 4.7547152448704235 -0.28720654001991075 (ac)ATFVELS(ph)TK ddPTM_A459_Selumetinib_30min_R2 1 ATFVELSTK 9 0 O60218;C9JRZ8 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 1 ATFVELS(0.805)T(0.195)K 83.081 0.006779899999999999 1092600.0 22918.0 24060.0 25999.0 24071.0 22872.0 27234.0 17529.0 20501.0 23299.0 28896.0 True False 21644.309308022996 25905.324634906538 24326.25264557087 20792.488275208903 19998.614881725694 30985.236294362596 18344.13323305455 20560.65451587676 27959.451028452233 28061.697399175573 0.7713114784232149 0.923156011071077 0.8668845757807064 0.7409561859155308 0.712665901753799 1.1041825394094982 0.6537071857097811 0.7326946129951787 0.9963563725576221 1.0 14.77631465704999 -8.280824732741351 23.293969582054093 0.9981784036382396 0.8172742680779016 0.26852024668778474 0.12197662647774479 542.5710734328894 651953.8819976802 0.11615212769605654 0.030235621852992896 5.238117874943477e-09 8.280824732741351 -0.18090413556033802 (ac)ATFVELSTK ddPTM_A459_Selumetinib_30min_R2 2 ATFVELSTK 9 0 O60218;C9JRZ8 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 0 ; 101.54 0.00070736 4346500.0 49754.0 46895.0 52564.0 53286.0 56530.0 39869.0 37217.6 44551.0 31060.5 45611.0 False True 46988.87186104265 50491.69570880889 49182.089467355974 46028.35487652287 49428.196015387904 45360.59285525235 38948.29214527534 44680.63603418492 37273.467902881705 44294.091918390004 1.0608383607370857 1.1399194231555239 1.110353262416394 1.039153369738975 1.115909455971177 1.0240777243797508 0.8793112231996071 1.0087267646553655 0.8414997641571814 1.0 15.434826660079993 -7.0210309867336775 4.273082974679347 0.9337086417244226 1.0928788942052492 0.6668540100309643 0.05350686722362893 0.12109705555405756 5.208051084669984 0.019274161429856822 0.015581398690921757 9.527281848321707e-08 7.0210309867336775 0.1591702524808266 (ac)ATNFLAHEK ddPTM_A459_Selumetinib_30min_R2 1 ATNFLAHEK 9 0 P29692;E9PI39;E9PQ49;E9PK01;E9PL12;P29692-3;E9PL71;E9PPR1;E9PMW7;P29692-4;E9PQZ1;E9PK06;E9PN91;E9PK72;E9PKK3;E9PJD0;E9PNW6 P29692 EEF1D Elongation factor 1-delta 0 62.582 0.048153 2333900.0 33059.0 30282.0 37282.0 36921.0 39932.0 23781.0 26795.0 27320.0 23548.0 31967.0 False True 31221.71312566243 32604.532028023237 34883.316709572406 31892.29610772251 34915.38516339061 27056.616887575692 28041.02059328523 27399.49667693054 28258.257986093507 31044.029649759337 1.0057235957415236 1.0502673910529523 1.1236723164849456 1.0273246246551548 1.124705315556909 0.8715562120262774 0.9032661323174136 0.8826011631239036 0.9102638512108422 1.0 14.922028217306307 -6.766713562150048 24.99977285151502 0.9055580689645715 1.066463563525106 0.7181960403681801 0.0477266298383215 64.79758917499208 307140.45779817126 0.015869544026485417 0.014410735364296942 1.7111435234689026e-07 6.766713562150048 0.1609054945605346 (ac)ATSAT(ph)SPHAPGFPAEGR ddPTM_A459_Selumetinib_30min_R1 1 ATSATSPHAPGFPAEGR 17 0 Q9NUP7;Q5VVL2;Q9NUP7-2 Q9NUP7 TRMT13 tRNA:m(4)X modification enzyme TRM13 homolog 1 AT(0.005)S(0.007)AT(0.494)S(0.494)PHAPGFPAEGR 94.454 0.017715 7391300.0 160.4 200.14 285.28 207.48 326.08 259.04 196.35 177.22 132.38 0.0 True False 164.13700791593106 176.70751575743822 246.5405429308707 171.2475128819599 296.58612157409976 256.4342927895017 181.53916141770807 172.51954990831103 224.63919134734368 0.0 0.0 (ac)ATSAT(ph)SPHAPGFPAEGR ddPTM_A459_Selumetinib_30min_R2 1 ATSATSPHAPGFPAEGR 17 0 Q9NUP7;Q5VVL2;Q9NUP7-2 Q9NUP7 TRMT13 tRNA:m(4)X modification enzyme TRM13 homolog 1 AT(0.035)S(0.035)AT(0.465)S(0.465)PHAPGFPAEGR 87.13799999999998 0.00078815 7694700.0 3735.9 2620.9 6814.0 10068.0 11019.0 11402.0 6095.0 6207.4 7650.7 6507.5 True False 3528.273633992629 2821.914602478243 6375.59465852225 8696.72103173127 9634.69470889014 12972.522002949338 6378.429577013379 6225.462506309609 9181.053778418798 6319.611566484464 0.5583054586304854 0.4465329194351174 1.0088586286433627 1.3761480338211938 1.5245707125398251 2.0527404044495445 1.0093072192665846 0.9851020811667973 1.4527876724433122 1.0 12.625620170860607 -5.467716720342453 2.7547820093295026 1.3649274700960852 0.4965887185539036 0.5450490117886116 0.304027577665936 0.2129276963769231 3.1565517301001615 0.09082428172670037 0.2139689355041634 3.4063030206015063e-06 5.467716720342453 -0.8683387515421817 (ac)ATSATS(ph)PHAPGFPAEGR ddPTM_A459_Selumetinib_30min_R1 1 ATSATSPHAPGFPAEGR 17 0 Q9NUP7;Q5VVL2;Q9NUP7-2 Q9NUP7 TRMT13 tRNA:m(4)X modification enzyme TRM13 homolog 1 AT(0.006)S(0.006)AT(0.12)S(0.868)PHAPGFPAEGR 63.54600000000001 0.0036073 6839200.0 339.35 157.46 157.47 182.93 322.19 208.4 229.77 191.9 151.96 58.093 True False 347.2561947398453 139.02450999883203 136.0864389207943 150.98470952138484 293.04797138726457 206.30368521206043 212.43826391111168 186.81018862095075 257.86502128072476 65.54980242373892 5.297593309207079 2.1208989937166334 2.0760770267632487 2.303358727847295 4.4706156319570685 3.1472815719326617 3.240868104190913 2.8498970509985435 3.933879458763078 1.0 6.034519526856564 (ac)ATSATS(ph)PHAPGFPAEGR ddPTM_A459_Selumetinib_30min_R2 1 ATSATSPHAPGFPAEGR 17 0 Q9NUP7;Q5VVL2;Q9NUP7-2 Q9NUP7 TRMT13 tRNA:m(4)X modification enzyme TRM13 homolog 1 AT(0.081)S(0.246)AT(0.176)S(0.497)PHAPGFPAEGR 70.167 0.0012501 6442100.0 18570.0 19511.0 16275.0 13647.0 18292.0 12514.0 15656.0 16057.0 12204.0 23328.0 True False 17537.95374159992 21007.430962246945 15227.884218880186 11788.255057611901 15993.995427445187 14237.689909218376 16384.03502177546 16103.723211620554 14645.141008250608 22654.460026576955 0.7741501550257814 0.92729780085697 0.6721804095536013 0.5203502994016443 0.7059976449971405 0.628471828174916 0.7232145459461237 0.7108411850350245 0.6464572976389524 1.0 14.46750748389607 -10.247958910786156 6.1433233916972325 1.0000000044078536 0.7004481533482481 0.44864720715429585 0.09943830974284432 6.4444725023000184e-09 1.5176921333639977e-09 0.1042835244742329 0.025292469412462746 5.6499042682531863e-11 10.247958910786156 -0.2995518510596056 (ac)ATTATMATSGS(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 ATTATMATSGSAR 13 0 I3L3H2;P38919 I3L3H2 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 ATTATMATS(0.003)GS(0.997)AR 136.14 9.0697e-05 5431500.0 23236.0 28880.0 26495.0 15825.0 23453.0 32154.0 18651.0 19982.0 22349.0 28090.0 True False 21944.63614107785 31095.003136163792 24790.34054557484 13669.607700352324 20506.624467519778 36582.92163504939 19518.308456255367 20040.144311801814 26819.424483234434 27278.968713415084 0.8044525572657024 1.139889248117803 0.9087711784860693 0.5011042698850257 0.7517375265522833 1.3410668863393969 0.7155075641351784 0.734637167641407 0.983153900170916 1.0 14.735501483582894 -8.486009981514066 22.6671694472348 1.0000005464631965 0.8677301608535135 0.051412458597606236 0.22193714057345387 577.049651489916 354773.39327498194 0.2221414467647117 0.05735667493554211 3.265803261972067e-09 8.486009981514066 -0.13227038560968296 (ac)ATVVVEATEPEPSGSIANPAASTS(ph)PSLSHR ddPTM_A459_Selumetinib_30min_R1 5 ATVVVEATEPEPSGSIANPAASTSPSLSHR 30 0 P46821;D6RA32;D6RGJ3;D6RCL2 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ATVVVEATEPEPSGSIANPAAS(0.034)T(0.258)S(0.615)PS(0.089)LS(0.004)HR;ATVVVEATEPEPSGSIANPAAS(0.027)T(0.196)S(0.498)PS(0.268)LS(0.011)HR;ATVVVEATEPEPS(0.001)GS(0.003)IANPAAS(0.082)T(0.226)S(0.629)PS(0.056)LS(0.002)HR;ATVVVEATEPEPSGSIANPAAS(0.103)T(0.237)S(0.549)PS(0.103)LS(0.007)HR;ATVVVEATEPEPSGS(0.001)IANPAAS(0.103)T(0.235)S(0.552)PS(0.101)LS(0.007)HR 125.26 3.7571999999999996e-27 265414000.0 782.16 775.32 1041.588 835.47 1012.26 568.38 592.6110000000001 550.5400000000001 373.03 623.71 True False 800.3828061815749 684.5451739635109 900.1460706333414 689.5708482142423 920.7012617290187 562.6626132477488 547.9098751561469 535.9378907940501 633.0046649667594 703.7692539498772 1.1372801549505862 0.9726841150299308 1.2790357998467639 0.9798251974550651 1.3082430875768145 0.7994987136619383 0.7785362490347856 0.7615250137543232 0.8994491609487707 1.0 9.45895867723122 -6.7812960244445595 24.9998964613051 0.8285679422486283 1.1257083531275067 0.5869181143108524 0.11996524205744133 159.49385033206642 200804.46331751885 0.03964916207778604 0.03501300084054625 1.6546417396622088e-07 6.7812960244445595 0.29714041087887844 (ac)ATVVVEATEPEPSGSIANPAASTS(ph)PSLSHR ddPTM_A459_Selumetinib_30min_R2 4 ATVVVEATEPEPSGSIANPAASTSPSLSHR 30 0 P46821;D6RA32;D6RGJ3;D6RCL2 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ATVVVEATEPEPSGSIANPAAS(0.219)T(0.16)S(0.455)PS(0.16)LS(0.006)HR;ATVVVEATEPEPSGSIANPAAS(0.026)T(0.207)S(0.549)PS(0.207)LS(0.011)HR;ATVVVEATEPEPS(0.023)GS(0.023)IANPAAS(0.081)T(0.194)S(0.475)PS(0.194)LS(0.01)HR;ATVVVEATEPEPSGSIANPAAS(0.044)T(0.243)S(0.518)PS(0.189)LS(0.006)HR 97.845 1.3230999999999997e-17 70109000.0 5097.5 9862.0 9572.74 9768.51 14435.21 8069.5 5649.5 8959.689999999999 4225.18 5488.91 True False 4814.201356909296 10618.383688671995 8956.840330411254 8438.022086380337 12621.729867385244 9181.00037737237 5912.212944271878 8985.761214543467 5070.334061393013 5330.430906399118 0.9031542555274295 1.9920310149644287 1.6803220016713238 1.5829906126820992 2.367862953111916 1.722374895873932 1.109143528560578 1.68574762009506 0.9512052872322458 1.0 12.380036448302633 -7.977606440128117 1.1088567332493922 0.9847654322162731 1.7178593381478953 0.2904418038571941 0.39319051978388375 0.6292442996169045 1.4124312712009508 0.3566912821700917 0.12806898591096483 1.0529155991022704e-08 7.977606440128117 0.7330939059316222 (ac)ATVWDEAEQDGIGEEVLK ddPTM_A459_Selumetinib_30min_R1 1 ATVWDEAEQDGIGEEVLK 18 0 E9PN50;R4GNH3 E9PN50 PSMC3 0 66.393 0.0097597 1034100.0 100.77 55.26300000000001 280.89 165.96 169.7 120.54 152.73 167.28 110.27 110.35 False True 103.11774493571308 48.79278226892833 242.74668081832672 136.9782014550321 154.35066496296844 119.32747704156321 141.2094531363715 162.84319099798145 187.1201361978515 124.51449740002391 0.8281585444980745 0.3918642671156054 1.9495455219038622 1.1000984167728391 1.2396200296828954 0.9583420367365214 1.1340804170193308 1.3078251480614351 1.5027979882269964 1.0 6.96016991688312 -5.22977755922772 24.999151594720427 1.261317826428736 0.6100112968798991 0.4583897623774815 0.2884515642454455 588.0295366738474 464287.40224454604 0.07160352326044225 0.18940750954216748 5.891453317355762e-06 5.22977755922772 -0.6513065295488368 (ac)AVAVGRPS(ph)NEELR ddPTM_A459_Selumetinib_30min_R2 2 AVAVGRPSNEELR 13 1 D6RGI3;D6RER5;Q9NVA2 D6RGI3 SEPT11 Septin-11 1 AVAVGRPS(1)NEELR;AVAVGRPS(1)NEELR 65.809 0.013728 22046000.0 9766.2 9978.7 15046.4 14480.6 12195.0 8946.2 5550.7 5428.7 5124.5 6205.0 True False 9223.433701196182 10744.034203422347 14078.331005281647 12508.317299571689 10662.95507531675 10178.457844482142 5808.818548503392 5444.496618230334 6149.543190493302 6025.845527473852 1.530645559887563 1.7829919725682795 2.3363245773715593 2.075777953905734 1.7695367441300578 1.6891335494869786 0.9639839790149015 0.9035240935744282 1.0205278516442997 1.0 12.556947974586851 -7.146857836405437 2.42974598640683 0.9467362484124494 1.92685440906416 0.8261967428488995 0.20179156715932034 0.12773015826572415 1.4730178367419111 0.09862385953172556 0.07098011701143923 7.130864163241035e-08 7.146857836405437 0.9801181606517105 (ac)CDFTEDQTAEFK ddPTM_A459_Selumetinib_30min_R1 1 CDFTEDQTAEFK 12 0 P60660-2;F8W1R7;G3V1V0;P60660;G3V1Y7 P60660-2 MYL6 Myosin light polypeptide 6 0 104.22 0.004630899999999999 1951200.0 511.76 651.16 826.43 747.8 810.72 574.24 619.66 455.67 439.52 682.81 False True 523.6830122883845 574.9218844839287 714.2053452550451 617.2107679445228 737.390519144241 568.4636669682034 572.9185473088716 443.5841513752404 745.8333387292978 770.4553146326261 0.6797058860423212 0.7462105505211122 0.9269912630761687 0.8010987220444128 0.9570840840988276 0.7378282116715129 0.7436103514738613 0.5757428665240025 0.96804230506857 1.0 9.589567474577882 -8.491148441787034 24.253456178235957 1.0000001326089891 0.7800444712109585 0.39829153426975916 0.10461406924523599 399.41848675492656 305300.80253153306 0.10510277374459201 0.02713741948783002 3.2273908114853873e-09 8.491148441787034 -0.21995566139803058 (ac)CDFTEDQTAEFK ddPTM_A459_Selumetinib_30min_R2 1 CDFTEDQTAEFK 12 0 P60660-2;F8W1R7;G3V1V0;P60660;G3V1Y7 P60660-2 MYL6 Myosin light polypeptide 6 0 95.573 0.01493 1121700.0 13108.0 14718.0 14601.0 15248.0 14457.0 10737.0 14713.0 11538.0 9819.4 12897.0 False True 12379.50983548152 15846.82327417101 13661.587556366803 13171.196095732845 12640.78241278017 12215.924289218292 15397.183653256407 11571.573669781277 11783.554376959686 12524.630099569755 0.988413209577086 1.265252797742536 1.090777727386624 1.0516235602187805 1.0092739116674116 0.9753521015872503 1.229352366564928 0.9239054229776241 0.9408305301858355 1.0 13.612480375273591 -6.526862601406995 0.4422638138397221 0.9757125535299922 1.1419604930398315 0.1538017269444657 0.10137365882947207 2.546374286167412 0.9906185054525817 0.09781902593289209 0.18311769145263057 2.9726063322558464e-07 6.526862601406995 0.1662479395098393 (ac)DDDIAALVVDNGS(ph)GMCK ddPTM_A459_Selumetinib_30min_R1 2 DDDIAALVVDNGSGMCK 17 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5 P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 1 DDDIAALVVDNGS(1)GMCK;DDDIAALVVDNGS(1)GMCK 181.51 1.1183999999999993e-109 2789600.0 975.5699999999999 1318.73 1584.79 1634.97 1847.5700000000002 1249.19 1746.21 2414.0 539.36 981.52 True False 998.298882871227 1164.3324785390562 1369.5842226283462 1349.4531816879603 1680.457619714978 1236.62428277377 1614.4919738182637 2349.972878222904 915.2545267042092 1107.5076528144223 0.9013923112263182 1.0513087431768344 1.2366363511330412 1.218459464599365 1.517332738464211 1.1165830589352892 1.457770490086892 2.121857011327283 0.826409212052255 1.0 10.113100952416891 -5.0738257174677965 0.8530465710905393 1.395552829510641 0.7454304956953562 0.13767835472389278 0.33435284337992816 2.800860308541646 2.1233150133825083 0.12484625919581288 1.5737974720916543 8.436732562219243e-06 5.0738257174677965 -0.6501223338152847 (ac)DDDIAALVVDNGSGMCK ddPTM_A459_Selumetinib_30min_R1 9 DDDIAALVVDNGSGMCK 17 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5 P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 0 ;;;;;;;; 243.13 1.2033999999999988e-196 211376900.0 12848.529999999999 12940.0 13469.83 14426.14 13997.39 11534.04 12287.169999999998 11704.449999999999 7336.960000000001 10963.21 False True 13147.875750112711 11424.978784357203 11640.70107047998 11906.885461186412 12731.328545939914 11418.018029670417 11360.338874442674 11394.00996458826 12450.285249643503 12370.444794208577 1.0628458368989369 0.9235705727983193 0.9410090958030677 0.9625268661932683 1.0291730619015649 0.923007880445491 0.9183452222963882 0.9210671203934842 1.006454129723153 1.0 13.59460975463028 -6.822805849162771 24.999999644474272 0.9466272944211447 0.9769190408770316 0.07151803770029708 0.04784938756510801 189.24138673756644 77092.63552460623 0.016853339619174595 0.014863252972044414 1.5038140941634986e-07 6.822805849162771 0.030291746455886948 (ac)DDDIAALVVDNGSGMCK ddPTM_A459_Selumetinib_30min_R2 7 DDDIAALVVDNGSGMCK 17 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5 P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 0 ;;;;;; 182.92 1.1624999999999998e-62 113858000.0 241273.09999999998 210843.1 250907.0 246214.2 255838.6 189739.2 204141.46 209273.8 191525.0 209452.5 False True 227864.1069947448 227014.08780257925 234763.916786886 212679.40121681456 223697.86784189675 215874.05251903203 213634.44238862884 209882.75211085755 229835.35165562047 203405.06210204944 1.1202479655124027 1.1160690174401118 1.1541694899859654 1.045595419400684 1.0997654902495313 1.0613012787790248 1.0502906868731088 1.0318462576194796 1.129939192665278 1.0 17.633996058148682 -1.522878745582493 0.09228084435523246 0.9645868581575885 1.4346239611162421 0.42835335406518227 0.03581011698459223 140.22178826100603 0.9310177863704675 0.6012211474998687 8.33816490217008 0.02999999997912784 1.522878745582493 0.47003710295865364 (ac)EEEIAALVIDNGS(ph)GMCK ddPTM_A459_Selumetinib_30min_R1 2 EEEIAALVIDNGSGMCK 17 0 P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 EEEIAALVIDNGS(1)GMCK;EEEIAALVIDNGS(1)GMCK 177.04 8.177e-52 11176200.0 1681.13 2250.0 2830.3 2540.16 2730.1 1951.4299999999998 2635.2 3379.9 1238.45 2008.76 True False 1720.2970580904569 1986.568954003378 2445.960805725053 2096.568740708691 2483.162937038302 1931.8003859566738 2436.4247423883094 3290.2540725375275 2101.559197190798 2266.603912979357 0.7589755970328302 0.8764517446685757 1.0791302316733138 0.9249824059258939 1.0955433910701615 0.852288472147479 1.074923028428787 1.4516228678934135 0.9271841388592615 1.0 11.146316588089167 -3.646314372635382 0.44034769745044705 1.1052785353686632 2.1913960167088665e-13 0.27233459537186533 0.1551730893875173 17.74500094606239 1.2348418094910036 0.10731591325994862 12.646772918823446 0.0002257800824843821 3.646314372635382 -1.105278535368444 (ac)EEEIAALVIDNGSGMCK ddPTM_A459_Selumetinib_30min_R1 2 EEEIAALVIDNGSGMCK 17 0 P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ; 142.97 9.3707e-11 105497000.0 1131.8200000000002 1307.93 1244.42 1257.94 1434.8 1340.07 1081.77 1098.56 852.79 1081.73 False True 1158.1892038616522 1154.7969475598402 1075.4345991097657 1038.264393458322 1305.022593334515 1326.5901124862082 1000.1712179619758 1069.4226201742142 1447.12234468274 1220.5805824424824 0.9488838512767589 0.9461046359176026 0.8810844728970966 0.8506315833573801 1.0691818402706827 1.0868517257841281 0.8194225210109034 0.8761589652968355 1.185601643594009 1.0 10.253351829312063 -7.493907144474387 0.42129154327480717 1.0283814859278682 0.9193882998920255 0.09457003960665089 0.10655415758278419 3.3408832734393274 1.4553123608217897 0.12454861176878988 0.11916711308733341 3.2069549230232026e-08 7.493907144474387 -0.10899318603584263 (ac)EEEIAALVIDNGSGMCK ddPTM_A459_Selumetinib_30min_R2 1 EEEIAALVIDNGSGMCK 17 0 P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 85.973 4.0234e-06 1374800.0 3360.9 3506.4 6247.3 6171.9 6218.7 4169.4 4823.1 3868.1 3404.9 5211.5 False True 3174.1146327486886 3775.329605146976 5845.35551954594 5331.276572878644 5437.451310116625 4743.697003955181 5047.383706791338 3879.355530601571 4085.975140854845 5061.030453896857 0.627167661143929 0.7459606575257958 1.1549733938165052 1.0533974496781986 1.0743763270442157 0.9372986484012682 0.9973035635272633 0.7665149549958886 0.8073405560539069 1.0 12.305215440208837 -5.060307531800354 6.191708570505489 0.9712623967732017 0.6536634799942904 0.5282286062647049 0.11110895371397751 0.16107239434200196 12.808131572144942 0.03153100085032261 0.08887169439802786 8.703470631521914e-06 5.060307531800354 -0.3175989167789113 (ac)KEGMSNNSTTS(ph)IS(ph)QARK ddPTM_A459_Selumetinib_30min_R1 1 KEGMSNNSTTSISQARK 17 2 P50150 P50150 GNG4 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 2 KEGMSNNS(0.172)T(0.172)T(0.172)S(0.701)IS(0.782)QARK 57.885 0.024629 17406000.0 1011.9 1185.3 931.5 1021.5 1117.1 932.96 1018.5 1202.2 651.96 1005.2 True False 1035.4753011853531 1046.52452496898 805.0074163632435 843.1142009298347 1016.0585022400234 923.5752694599034 941.673725000946 1170.3137507040487 1106.3285027255938 1134.2272114771554 0.9129346313573334 0.9226762630796379 0.7097408775044692 0.7433380123474634 0.89581566370354 0.814277122003703 0.8302337622234982 1.0318159702586365 0.9754028924105711 1.0 10.147493958484162 -7.755416760693753 24.93746204372611 1.0027070867543098 0.8297267826071113 0.5806269149701188 0.06605275201678387 101.70240397322198 421117.83300584403 0.034481448667290054 0.01924099273126774 1.7562374722266723e-08 7.755416760693753 -0.17298030414719845 (ac)KIEEVKS(ph)T(ph)T(ph)K ddPTM_A459_Selumetinib_30min_R2 1 KIEEVKSTTK 10 2 Q9Y265;Q9Y265-2 Q9Y265 RUVBL1 RuvB-like 1 3 KIEEVKS(1)T(1)T(1)K 67.169 0.02843 0.0 11817.0 14730.0 10992.0 13233.0 11054.0 11605.0 14356.0 11894.0 9145.5 10482.0 True False 11160.258447199036 15859.743635584924 10284.7866871847 11430.642571801734 9665.29769598617 13203.48341029882 15023.582445874337 11928.609570842298 10974.855546620447 10179.357424493304 1.0963617821637262 1.558029939829367 1.0103571628635137 1.1229237853754521 0.9494997859815574 1.2970841733613698 1.47588711343655 1.1718430813854703 1.078148166819748 1.0 13.313358873207049 -8.34783121133088 3.062087335657687 1.0103688976511924 1.2161660144952313 0.13179025432249192 0.18139968459283484 0.5341699238794688 9.198097817665797 0.17756547916910553 0.048458294076103775 4.489198288472795e-09 8.34783121133088 0.2057971168440389 (ac)LIWS(ph)EVSWIPNK ddPTM_A459_Selumetinib_30min_R1 1 LIWSEVSWIPNK 12 0 B0QY08 B0QY08 LARGE 1 LIWS(0.866)EVS(0.134)WIPNK 68.786 0.013391 32534000.0 8798.4 6422.9 7840.8 9323.4 7534.2 6376.7 6073.5 5169.1 3861.8 4778.8 True False 9003.38560129381 5670.903882074797 6776.062426431473 7695.243211893504 6852.73294027105 6312.556187580354 5615.371005197095 5031.998676396854 6553.1925452875985 5392.205529453869 1.6697037143919267 1.0516854098195243 1.2566402355063353 1.4271049517418692 1.2708590024692745 1.1706816724806297 1.0413866783312002 0.9331986047101775 1.215308376042431 1.0 12.396659772033633 -6.925596610447988 2.245372634458341 1.0426215361736535 1.324369762684785 0.42258668267251964 0.1593435298517118 0.3190795621610344 3.2666046879244437 0.06452000593577831 0.05344786185210476 1.1868706478160194e-07 6.925596610447988 0.2817482265111315 (ac)LSMICS(ph)RNLTAPNPMK ddPTM_A459_Selumetinib_30min_R1 1 LSMICSRNLTAPNPMK 16 1 O43147-3 O43147-3 SGSM2 Small G protein signaling modulator 2 1 LS(0.005)MICS(0.759)RNLT(0.235)APNPMK 49.216 0.019951 4999000.0 704.71 740.62 1230.8 903.35 861.79 690.44 726.06 591.63 431.08 519.64 True False 721.128371873041 653.9078660951031 1063.6641203004615 745.5968804796532 783.8412466613818 683.4948004693621 671.2927096457407 575.9380505149194 731.5112751625087 586.3408557222333 1.2298791135486906 1.1152350372884101 1.8140713032699705 1.2716099743062492 1.336835458439741 1.1656953353991648 1.1448847595974987 0.9822580925313483 1.2475870784434078 1.0 9.195595775750599 -6.843646064807054 1.8869346313815774 1.0901288733857064 1.370380391444626 0.31442394293536235 0.1839219588835376 0.43376604974794103 3.1752047428167747 0.07945879525471446 0.06858729897148536 1.4333555593095756e-07 6.843646064807054 0.28025151805891957 (ac)MAAAMVPGRS(ph)ES(ph)WER ddPTM_A459_Selumetinib_30min_R1 2 MAAAMVPGRSESWER 15 1 O43598;O43598-2 O43598 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 2 MAAAMVPGRS(1)ES(1)WER;MAAAMVPGRS(1)ES(1)WER 78.324 0.025943 37179000.0 625.52 794.3900000000001 570.23 780.14 1016.97 732.38 1074.92 542.9300000000001 401.37 532.81 True False 640.0933989499579 701.3824494981085 492.795898049181 643.9031940415083 924.9852430606368 725.0129221478351 993.8379189769436 528.5297327148139 681.0955750950544 601.2013535088964 1.0646905487056357 1.1666348477170048 0.8196852771088925 1.07102751895581 1.5385614780505465 1.2059402692896741 1.6530866292572926 0.8791226593720449 1.1328909542865422 1.0 9.23170444703029 -6.021621854701772 24.642499591539746 1.2534793098081676 1.0175316120907258 0.16036913541075637 0.22929303062638615 1094.1706080558251 1247030.1860308729 0.06793454992180438 0.08861096807072132 9.514328568474111e-07 6.021621854701772 -0.23594769771744173 (ac)MAPS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 MAPSPTK 7 0 H3BMS0;Q15287-3;Q15287-2 H3BMS0 RNPS1 RNA-binding protein with serine-rich domain 1 1 MAPS(0.928)PT(0.072)K 54.539 0.047892 17873000.0 121420.0 112720.0 146260.0 148660.0 133810.0 119550.0 127860.0 119280.0 100560.0 125010.0 True False 114671.96248277131 121365.26154807389 136849.7908358476 128412.25154719589 116999.59152342218 136016.9273331514 133805.74334978344 119627.08505213313 120674.8098811605 121400.6364850133 0.9445746398284112 0.9997086099549093 1.1272576058754147 1.0577559991874357 0.9637477603988145 1.120397151706387 1.1021832110929792 0.9853909214627626 0.994021229007787 1.0 16.889416459880202 -7.810978891161144 24.997692425833975 0.9922793680857033 1.0467594815316823 0.1397634528665208 0.05895061269819937 238.23153528490855 120208.66187253705 0.03386993041598109 0.016270633079362593 1.545329548297648e-08 7.810978891161144 0.05448011344597903 (ac)MDDREDLVYQAK ddPTM_A459_Selumetinib_30min_R1 2 MDDREDLVYQAK 12 1 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 ; 60.398 0.012661 40815000.0 5750.799999999999 5631.6 6497.4 7693.1 6745.4 5775.799999999999 5628.3 6116.1 3637.7 4315.4 False True 5884.782450891122 4972.24965394019 5615.088767663484 6349.644502372303 6135.279760997093 5717.700696006808 5203.752799629673 5953.881160107332 6172.911212904007 4869.323625555623 1.2085420693761402 1.0211376438083477 1.1531557972844255 1.3040095484817493 1.2599860335421875 1.174228935205427 1.06868082711095 1.2227326869094584 1.2677143044070387 1.0 12.249505673021954 -10.656782816893937 3.857684971954735 0.9999261063209319 1.183661617683574 0.3083494348046485 0.08376973529639944 14676709.01593807 27144052.551383898 14729.341096439823 0.022480877585798885 2.204028383710792e-11 10.656782816893937 0.183735511362642 (ac)MDDREDLVYQAK ddPTM_A459_Selumetinib_30min_R2 1 MDDREDLVYQAK 12 1 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 72.928 0.001348 19953000.0 52267.0 40587.0 50672.0 56610.0 53147.0 37613.0 34802.0 37183.0 38935.0 48071.0 False True 49362.20938137869 43699.892392225745 47411.81868750211 48899.62034230304 46470.19871979166 42793.849333181344 36420.36195885472 37291.19637402297 46723.087934794945 46683.0653265424 1.057390062886745 0.9360973210852861 1.0156106578662343 1.047480922691261 0.9954401750343136 0.9166889327820172 0.7801621788136381 0.7988163612045516 1.0008573260554463 1.0 15.510611674660854 -6.83035867456277 3.7084898589772135 0.8750953436118794 1.0096157231521057 0.34593320605929545 0.07467638417942245 0.23083471869816505 6.312573803626486 0.02711645538797579 0.024281831640194956 1.4778873283463094e-07 6.83035867456277 0.13452037954022633 (ac)MDEETRHS(ph)LECIQANQIFPR ddPTM_A459_Selumetinib_30min_R2 1 MDEETRHSLECIQANQIFPR 20 1 Q13615-3;Q13615-2;Q13615;C9JLU3 Q13615-3 MTMR3 Myotubularin-related protein 3 1 MDEET(0.396)RHS(0.604)LECIQANQIFPR 59.9 0.0024504 2355500.0 3900.7 3548.4 3385.9 4005.1 4950.3 3313.9 2987.3 3607.1 3333.5 3403.9 True False 3683.9147097393015 3820.550870095689 3168.0548802891817 3459.598470817134 4328.399057756501 3770.3596444109626 3126.2153692226525 3617.5960638124466 4000.2931457721565 3305.6205626056803 1.1144396762934667 1.1557741724247113 0.9583843094780178 1.046580636009258 1.3094058969504376 1.1405905708182515 0.9457272273132249 1.09437728719864 1.2101489175814224 1.0 11.690705418287044 -9.82496009617763 10.368208774519156 0.9999999991411196 1.1052095924961218 0.08910340456979904 0.10351287815239422 0.0 0.0 0.10483840512796513 0.025427048115523324 1.4963731394550237e-10 9.82496009617763 0.10520959335500224 (ac)MDEPS(ph)PLAQPLELNQHSR ddPTM_A459_Selumetinib_30min_R1 2 MDEPSPLAQPLELNQHSR 18 0 Q13085;A0A0C4DGT1;A0A087X2F8;A0A087X126 Q13085 ACACA Acetyl-CoA carboxylase 1;Biotin carboxylase 1 MDEPS(1)PLAQPLELNQHSR;MDEPS(1)PLAQPLELNQHSR 149.31 9.1056e-06 18572600.0 0.0 0.0 0.0 126.49600000000001 122.54 0.0 0.0 132.74 0.0 0.0 True False 0.0 0.0 0.0 104.40584822400423 111.45627863619418 0.0 0.0 129.2193039997134 0.0 0.0 0.0 (ac)MDEPS(ph)PLAQPLELNQHSR ddPTM_A459_Selumetinib_30min_R2 3 MDEPSPLAQPLELNQHSR 18 0 Q13085;A0A0C4DGT1;A0A087X2F8;A0A087X126 Q13085 ACACA Acetyl-CoA carboxylase 1;Biotin carboxylase 1 MDEPS(1)PLAQPLELNQHSR;MDEPS(1)PLAQPLELNQHSR;MDEPS(1)PLAQPLELNQHSR 147.73 2.3596e-08 11807700.0 3203.1299999999997 2987.61 2617.3199999999997 3316.98 4591.009999999999 1246.76 2552.6 2341.15 2884.3 1666.59 True False 3025.1128577453364 3216.750080319746 2448.9244807225496 2865.201601890343 4014.2462796498526 1418.489873039565 2671.3009578809438 2347.962358901753 3461.2405940754866 1618.471216379154 1.8691174900923622 1.987523811215045 1.513109690144065 1.7703135977298232 2.480270417555235 0.8764381217807584 1.6505087831325058 1.450728524017015 2.138586438267947 1.0 10.660415992899127 -6.761024839268634 24.99999731590777 1.4656265286810681 1.8962194680876336 0.28196446458177626 0.39547976956690317 17.684259787400766 1066521.1071273782 0.1331441363884247 0.12544018526934592 1.733704836485701e-07 6.761024839268634 0.4305929394065655 (ac)MDHTEGSPAEEPPAHAPS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 MDHTEGSPAEEPPAHAPSPGK 21 0 D6R946;Q06330 D6R946 RBPJ Recombining binding protein suppressor of hairless 1 MDHT(0.008)EGS(0.008)PAEEPPAHAPS(0.984)PGK 40.626 0.022544 41794000.0 29639.0 18691.0 22712.0 30122.0 22536.0 73529.0 20155.0 24031.0 62035.0 47289.0 True False 27991.783034317712 20124.539598962514 21250.734646955865 26019.3316366517 19704.826205603786 83656.95232019492 21092.247436374826 24100.9262314538 74443.7334027226 45923.64369842241 0.6095287912722678 0.4382173969278017 0.4627406045240674 0.5665781183984215 0.42907802209694207 1.8216531961088431 0.45928950182799616 0.5248043119078926 1.6210328146344346 1.0 15.486949493189732 (ac)MDLAAAAEPGAGS(ph)QHLEVR ddPTM_A459_Selumetinib_30min_R1 3 MDLAAAAEPGAGSQHLEVR 19 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 MDLAAAAEPGAGS(1)QHLEVR;MDLAAAAEPGAGS(1)QHLEVR;MDLAAAAEPGAGS(1)QHLEVR 167.97 3.2975e-19 44430100.0 197.298 0.0 0.0 310.65999999999997 247.13 115.04 0.0 81.895 66.11399999999999 0.0 True False 201.89465952492125 0.0 0.0 256.4090628104377 224.77713513434523 113.8828020479627 0.0 79.72287856754956 112.19062922449221 0.0 0.0 (ac)MDLAAAAEPGAGS(ph)QHLEVR ddPTM_A459_Selumetinib_30min_R2 4 MDLAAAAEPGAGSQHLEVR 19 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 MDLAAAAEPGAGS(1)QHLEVR;MDLAAAAEPGAGS(1)QHLEVR;MDLAAAAEPGAGS(1)QHLEVR;MDLAAAAEPGAGS(1)QHLEVR 156.08 1.6561e-14 26995700.0 711.88 616.78 3320.75 1326.03 1204.04 2495.27 1797.87 583.65 1241.4 846.98 True False 672.3165594814299 664.0850427397195 3107.0965603592235 1145.4224264706604 1052.7777309458286 2838.9707926942096 1881.4745174118189 585.3483248715412 1489.714687614086 822.525486681677 0.8173808232906721 0.8073732103048193 3.7775079443364303 1.3925677015695281 1.2799332640658474 3.451529270111129 2.2874361316173566 0.7116476441757664 1.8111471458763633 1.0 9.683916572500525 -5.097750147406742 21.592391685589504 1.994788313738689 0.8094045587803963 0.19143506232658525 0.944959226665286 20.43228245780825 4504.836418319604 0.2420805901856312 0.6404890477133309 7.984539111678199e-06 5.097750147406742 -1.1853837549582926 (ac)MDLAAAAEPGAGS(ph)QHLEVRDEVAEK ddPTM_A459_Selumetinib_30min_R1 2 MDLAAAAEPGAGSQHLEVRDEVAEK 25 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 MDLAAAAEPGAGS(1)QHLEVRDEVAEK;MDLAAAAEPGAGS(1)QHLEVRDEVAEK 56.684 1.7796e-07 14033000.0 957.37 1153.29 1979.33 2291.31 1551.69 1541.87 1143.26 1135.83 596.74 673.02 True False 979.674858282263 1018.2622706500254 1710.5478576814353 1891.1757217156517 1411.339913473121 1526.360187705948 1057.0229777560937 1105.7040987041926 1012.6241958348227 759.4086727699513 1.2900496049233787 1.340862051174505 2.252473429678112 2.490326736482437 1.8584722088111576 2.009932520441902 1.391902694369543 1.4560066777630087 1.3334377551171033 1.0 9.568732665016626 -7.333741708627674 5.071537497551332 1.3222710580333128 1.8937355343288953 0.38183784539008025 0.35975111424025713 0.28350882775475666 13.687933494380102 0.17174994038170313 0.11467309411635773 4.6372263114708975e-08 7.333741708627674 0.5714644762955825 (ac)MDLFGDLPEPERS(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 MDLFGDLPEPERSPR 15 1 F8SNU6;E9PC05;F8SNU7;Q9H0C8 F8SNU6 ILKAP2;ILKAP;ILKAP3 Integrin-linked kinase-associated serine/threonine phosphatase 2C 1 MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR 135.55 3.7419e-05 40288300.0 753.96 861.05 1139.77 1265.3 1041.212 927.777 887.012 757.9169999999999 337.53999999999996 518.0260000000001 True False 771.5258010492231 760.2378657087147 984.9954943084638 1044.3391076226333 947.0345584409087 918.4444057341159 820.1039707025419 737.8145790986192 572.7807270538025 584.5196831005421 1.3199312586989724 1.3006197869609595 1.6851365707372365 1.7866620026942677 1.6201927596645382 1.5712805441594273 1.4030391010142893 1.2622578852861472 0.9799169191626341 1.0 9.191107796624763 -7.914232178022886 1.6166805937936313 0.9784548021419475 1.554920669098084 0.7007121976403571 0.14264508582121113 0.24602110813495237 1.1739183975267333 0.13749256665748974 0.0481981622651474 1.2183380894837807e-08 7.914232178022886 0.5764658669561364 (ac)MDLFGDLPEPERS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 MDLFGDLPEPERSPR 15 1 F8SNU6;E9PC05;F8SNU7;Q9H0C8 F8SNU6 ILKAP2;ILKAP;ILKAP3 Integrin-linked kinase-associated serine/threonine phosphatase 2C 1 MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR;MDLFGDLPEPERS(1)PR 77.726 0.0043247 13100600.0 1886.9099999999999 1981.7800000000002 3043.7799999999997 4676.360000000001 3729.7599999999998 1949.3200000000002 2460.05 537.44 1690.12 3031.7400000000002 True False 1782.0430960992085 2133.776153572945 2847.946508617091 4039.4317008290445 3261.1942043225413 2217.8211358348703 2574.447199496596 539.0038614220185 2028.1912258984369 2944.205788793485 0.6052712425477151 0.7247374357100737 0.9673055190154215 1.3719936684467886 1.107665169580064 0.7532833283177932 0.874411431869233 0.18307275377068616 0.6888754969568807 1.0 11.523662798480869 -7.5516900955713195 24.989736510440668 0.5673325724005909 0.932923671521284 0.18277611423577322 0.2751539267963037 302.0615633156778 261991.8569016995 0.1349313680988621 0.07790416272640505 2.8074362574148343e-08 7.5516900955713195 0.3655910991206931 (ac)MDLFGDLPEPERS(ph)PRPAAGK ddPTM_A459_Selumetinib_30min_R1 3 MDLFGDLPEPERSPRPAAGK 20 2 F8SNU6;E9PC05;F8SNU7;Q9H0C8 F8SNU6 ILKAP2;ILKAP;ILKAP3 Integrin-linked kinase-associated serine/threonine phosphatase 2C 1 MDLFGDLPEPERS(1)PRPAAGK;MDLFGDLPEPERS(1)PRPAAGK;MDLFGDLPEPERS(1)PRPAAGK 71.263 0.00039253 64042000.0 7070.7 7421.0 8421.0 9124.6 7755.8 6735.200000000001 7052.9 6372.699999999999 4213.95 5647.299999999999 True False 7235.433552812802 6552.145870070699 7277.474453241946 7531.159899955325 7054.289259397704 6667.450003072311 6520.89407467763 6203.675294553061 7150.765375269217 6372.185964360261 1.1354711857564577 1.0282414710928018 1.1420687490831214 1.1818801180752139 1.107043846311526 1.0463363813240019 1.023337063787701 0.9735552805976343 1.1221840378268246 1.0 12.637572655408775 -6.788970856642032 3.62532947192541 1.028675330832273 1.1197167851496799 0.4221737757634333 0.05065939803452296 0.23630888807946174 6.547517515504194 0.018652302600091472 0.01709182767783219 1.6256578419599777e-07 6.788970856642032 0.09104145431740696 (ac)MDNVQS(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 MDNVQSKR 8 1 F5GYR7 F5GYR7 ATF7IP 1 MDNVQS(1)KR 44.377 0.03262 0.0 54255.0 37669.0 78181.0 91302.0 113160.0 83074.0 59423.0 80494.0 97491.0 64357.0 True False 51239.72429997324 40558.09117507457 73150.91957703685 78866.51009526504 98943.82913676443 94516.68942931171 62186.287244440646 80728.2242135009 116991.9241261358 62498.846190432705 0.819850724025318 0.6489414388786459 1.1704363206025836 1.2618874571693754 1.5831304922859633 1.5122949492750841 0.9949989645402461 1.2916754329755729 1.8719053431748771 1.0 15.931541935552877 -5.45235363831068 2.5220729694482285 1.3730014747464865 0.7268217190701196 0.4866420541505122 0.2519642389573072 0.24045805995912706 2.9640286733018146 0.07103601043329337 0.1773049534682854 3.5289569604553646e-06 5.45235363831068 -0.6461797556763669 (ac)MDNYADLS(ph)DTELTTLLR ddPTM_A459_Selumetinib_30min_R1 2 MDNYADLSDTELTTLLR 17 0 P50402;Q5HY57;F8WEQ1 P50402 EMD Emerin 1 MDNY(0.006)ADLS(0.993)DT(0.001)ELTTLLR;MDNY(0.003)ADLS(0.979)DT(0.017)ELTTLLR 143.67 4.274800000000001e-05 4305700.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)MDRNPS(ph)PPPPGR ddPTM_A459_Selumetinib_30min_R1 3 MDRNPSPPPPGR 12 1 E9PL53;E9PMD2;J3KND1;E9PRZ1;Q96ER3 E9PL53 SAAL1 Protein SAAL1 1 MDRNPS(1)PPPPGR;MDRNPS(1)PPPPGR;MDRNPS(1)PPPPGR 89.029 0.0015738 467939000.0 65.705 113.05 96.463 215.243 0.0 0.0 0.0 62.28 0.0 0.0 True False 67.23579866032576 99.81405344448082 83.36385443333063 177.6548506615177 0.0 0.0 0.0 60.62813208604905 0.0 0.0 0.0 (ac)MDRNPS(ph)PPPPGR ddPTM_A459_Selumetinib_30min_R2 2 MDRNPSPPPPGR 12 1 E9PL53;E9PMD2;J3KND1;E9PRZ1;Q96ER3 E9PL53 SAAL1 Protein SAAL1 1 MDRNPS(1)PPPPGR;MDRNPS(1)PPPPGR 84.89200000000002 0.0015095 168695600.0 10579.099999999999 8487.4 15999.300000000001 12369.8 19634.6 9778.9 8841.7 10359.1 15342.3 9651.1 True False 9991.155973492707 9138.356288707637 14969.922456720717 10685.011900904787 17167.926012448883 11125.854710984146 9252.85656949618 10389.243265958678 18411.18869967906 9372.447666430771 1.06601352486373 0.975023453205124 1.5972265719165741 1.1400449787706168 1.8317441316785497 1.1870810173561748 0.9872401424696208 1.1084877329504603 1.9643949323528669 1.0 13.194210149524176 -5.235136839390044 24.448349059515852 1.3465448934665163 1.0205183561672433 0.14233674366400617 0.32528039616525456 1144.6434382374841 1063946.5463489573 0.08136073888211752 0.21509263906526402 5.819198350549198e-06 5.235136839390044 -0.326026537299273 (ac)MDS(ph)AGQDINLNSPNK ddPTM_A459_Selumetinib_30min_R1 1 MDSAGQDINLNSPNK 15 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 MDS(0.76)AGQDINLNS(0.24)PNK 133.75 4.2642e-05 11134000.0 6728.7 8928.6 5085.8 5416.6 4456.8 5922.7 6445.8 6497.4 3981.1 7083.9 True False 6885.465618228958 7883.235361206473 4395.176294299714 4470.692492174783 4053.6832269119473 5863.123015381335 5959.588116456651 6325.067845470377 6755.635931960341 7993.187568029264 0.8614167451504685 0.9862442603921153 0.54986527676134 0.5593128466115854 0.5071422623842406 0.7335150045561735 0.7455834190972199 0.7913073215958367 0.8451742029651828 1.0 12.964555228556394 -8.395814023912873 1.0833817726623556 0.9942187133481553 0.6949812716150822 0.31065253949701765 0.13807037584342113 0.6789740122526892 1.718205173882619 0.14704171775543012 0.048303894119367294 4.019629048715534e-09 8.395814023912873 -0.2992374417330731 (ac)MDSAGQDINLNS(ph)PNK ddPTM_A459_Selumetinib_30min_R1 1 MDSAGQDINLNSPNK 15 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 MDS(0.068)AGQDINLNS(0.932)PNK 141.82 2.6741e-05 12544000.0 4447.2 5411.7 3333.1 3671.1 3468.4 4089.3 4833.5 4401.4 2549.0 5352.8 True False 4550.811107255168 4778.095648168923 2880.4833274077564 3030.0113000817555 3154.6838323957536 4048.165354787328 4468.905203526827 4284.660574237896 4325.4668284059435 6039.884020687345 0.753460015402296 0.7910906288603156 0.47691037071932957 0.5016671329620891 0.522308677052502 0.670238921959737 0.7398991749212862 0.7093945114777713 0.7161506435538644 1.0 12.560305131499579 -8.909566158508294 0.6270877368476838 1.0049974457091873 0.6163863176636372 0.5365925061784678 0.10171275667343767 1.2469337865184262 0.9247985661884688 0.13383262252683148 0.047495980465896946 1.2314983704095066e-09 8.909566158508294 -0.3886111280455501 (ac)MDSAGQDINLNS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 5 MDSAGQDINLNSPNK 15 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 MDSAGQDINLNS(1)PNK;MDSAGQDINLNS(1)PNK;MDSAGQDINLNS(1)PNK;MDSAGQDINLNS(1)PNK;MDSAGQDINLNS(1)PNK 252.12 7.962099999999997e-96 50935500.0 303198.0 240886.0 279755.0 306235.0 297025.0 278853.0 360087.0 342099.0 279067.0 271466.0 True False 286347.4689577607 259361.18162943082 261755.86787421347 264525.26471515873 259710.06406280908 317262.46957449836 376831.75899885444 343094.45145246154 334888.1977834707 263628.07122662634 1.0861797365713903 0.9838147372647296 0.9928983156319364 1.003403254760989 0.9851381260516481 1.203447220541873 1.4294068049942723 1.3014336821419992 1.2703055339489473 1.0 18.0081444717298 -6.867638701415746 4.367173112688511 1.2801607713235006 1.0076369770267501 0.5426221204461319 0.10475396646704835 0.14397178462217286 4.834054850243614 0.03610059835634339 0.03187971468677626 1.3563172916099905e-07 6.867638701415746 -0.27252379429675044 (ac)MDSAGQDINLNS(ph)PNKGLLSDSMTDVPVDTGVAAR ddPTM_A459_Selumetinib_30min_R1 2 MDSAGQDINLNSPNKGLLSDSMTDVPVDTGVAAR 34 1 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 MDS(0.095)AGQDINLNS(0.848)PNKGLLS(0.021)DS(0.025)MT(0.011)DVPVDTGVAAR;MDS(0.065)AGQDINLNS(0.922)PNKGLLS(0.008)DS(0.004)MT(0.001)DVPVDTGVAAR 56.709 1.4969999999999995e-14 10938800.0 1207.94 1004.6500000000001 1501.42 1547.95 1390.67 1354.27 1322.0300000000002 982.13 722.69 877.75 True False 1236.082651757916 887.0251109508861 1297.5354107097153 1277.6295911202521 1264.8841440427307 1340.6472733787768 1222.3082127275406 956.0807219921545 1226.3521468107863 990.417762509026 1.2480416835685044 0.8956070302129727 1.3100889945901897 1.2899905872887742 1.27712182871034 1.3536179621642832 1.2341339775965512 0.9653307505007932 1.2382170365200917 1.0 9.951893378371624 -7.731678796207688 24.932570485459042 1.0763304103636204 1.228932090798187 0.22963344808451647 0.1356597895936839 314.89248959443273 263808.1500488112 0.06615230411559392 0.038186281014584905 1.8549030007407474e-08 7.731678796207688 0.15260168043456668 (ac)MDSAGQDINLNS(ph)PNKGLLSDSMTDVPVDTGVAAR ddPTM_A459_Selumetinib_30min_R2 2 MDSAGQDINLNSPNKGLLSDSMTDVPVDTGVAAR 34 1 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 MDS(0.371)AGQDINLNS(0.623)PNKGLLS(0.002)DS(0.002)MT(0.002)DVPVDTGVAAR;MDS(0.068)AGQDINLNS(0.921)PNKGLLS(0.009)DS(0.002)MT(0.001)DVPVDTGVAAR 56.68 3.5476999999999997e-25 5611000.0 1129.5 1191.75 1441.19 1186.4 1242.7 1325.9 0.0 669.59 0.0 1700.07 True False 1066.7269117467474 1283.1533929197783 1348.465404449029 1024.810273345846 1086.5809161210432 1508.530689678173 0.0 671.5383960434084 0.0 1650.9845617876674 0.6461156187867121 0.7772049615838893 0.8167643935985239 0.6207267451587755 0.658141173012851 0.9137158060671101 0.0 0.4067502577469739 0.0 1.0 10.689110914461104 -7.251234134743242 24.996323798691385 0.3022500770051719 0.7350383356076399 0.31867927596546575 0.27345126782574897 710.3513886665614 1739909.4397918568 0.09736085276859396 0.074545241547856 5.6074558807604274e-08 7.251234134743242 0.43278825860246795 (ac)MDT(ph)PLRR ddPTM_A459_Selumetinib_30min_R1 1 MDTPLRR 7 1 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 MDT(1)PLRR 62.464 0.02408 10348000.0 0.0 121.35 0.0 137.91 112.08 114.84 0.0 0.0 0.0 0.0 True False 0.0 107.14228558591556 0.0 113.82660739132005 101.94238378933115 113.68481386637725 0.0 0.0 0.0 0.0 0.0 (ac)MDVAES(ph)PERDPHSPEDEEQPQGLSDDDILR ddPTM_A459_Selumetinib_30min_R1 1 MDVAESPERDPHSPEDEEQPQGLSDDDILR 30 1 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 MDVAES(0.5)PERDPHS(0.5)PEDEEQPQGLSDDDILR 48.213 4.1688e-07 20171000.0 191.86 318.07 361.03 301.54 278.69 351.77 286.53 349.3 135.83 192.58 True False 196.3299647054273 280.8302165332688 312.00410899583625 248.88169960683524 253.4825387067157 348.2315131816049 264.9168114133736 340.0354293136951 230.49358936931327 217.2995188880527 0.9034993069016947 1.2923646493573029 1.4358251255796521 1.1453393955053022 1.1665121947982942 1.602541574705488 1.2191320660486695 1.564823663916499 1.0607183603018369 1.0 7.76354117009885 -4.761943436239362 7.535284962548238 1.30027861524837 0.8972446033818686 0.2421058550948082 0.19384610985924547 0.12888535045353106 53.29213542567643 0.04525013563531644 0.26636179010576994 1.7300416701380968e-05 4.761943436239362 -0.40303401186650145 (ac)MDVAES(ph)PERDPHSPEDEEQPQGLSDDDILR ddPTM_A459_Selumetinib_30min_R2 4 MDVAESPERDPHSPEDEEQPQGLSDDDILR 30 1 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 MDVAES(0.5)PERDPHS(0.5)PEDEEQPQGLSDDDILR;MDVAES(0.983)PERDPHS(0.017)PEDEEQPQGLSDDDILR;MDVAES(0.894)PERDPHS(0.105)PEDEEQPQGLS(0.001)DDDILR;MDVAES(0.977)PERDPHS(0.023)PEDEEQPQGLSDDDILR 107.87 1.5975e-18 31131300.0 4224.26 4945.52 4890.719999999999 5387.389999999999 6034.12 6975.6 5381.88 3838.6000000000004 2958.1000000000004 3739.85 True False 3989.492540252604 5324.825481646837 4576.056399813316 4653.6181882338815 5276.059899882761 7936.425581807878 5632.148083992904 3849.769690485562 3549.8026562197756 3631.870813202753 1.0984676342974005 1.4661384601813954 1.259972238874305 1.2813281164398311 1.452711335629828 2.1852169281343925 1.5507567239227358 1.0599963182860723 0.977403338057995 1.0 11.826497171083194 -7.804737556768377 6.39864208378169 1.0064443846960425 1.4818734624901424 0.3734274036787333 0.2719830003942514 0.232191302424555 23.457573515047784 0.1638330245246985 0.0791196023680467 1.5676981405746794e-08 7.804737556768377 0.47542907779409993 (ac)MEDLDQS(ph)PLVSSSDSPPRPQPAFK ddPTM_A459_Selumetinib_30min_R1 1 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.826)PLVS(0.037)S(0.129)S(0.007)DS(0.001)PPRPQPAFK 61.304 3.702e-06 3825600.0 1256.9 1433.4 1744.5 1180.0 1350.1 1422.0 1379.7 1529.6 731.31 1048.6 True False 1286.1833244983409 1265.5768616304185 1507.6064818525788 973.9351513433235 1227.9836933795148 1407.6959710726971 1275.6281181971576 1489.0300391589694 1240.9796572308953 1183.1980242289537 1.0870397838404935 1.0696238801236573 1.2741793435929967 0.8231379121664786 1.037851372495104 1.1897382705570696 1.0781188711234007 1.2584791460662852 1.0488351331042796 1.0 10.208475833119861 -6.738647100754451 24.947916337803743 1.1288820477716979 1.0579132126970499 0.04518175826982507 0.1222179808564892 679.8649419400018 744163.1585349638 0.04024887009518971 0.04022125005526562 1.8253783667887833e-07 6.738647100754451 -0.07096883507464802 (ac)MEDLDQSPLVS(ph)SSDSPPRPQPAFK ddPTM_A459_Selumetinib_30min_R1 1 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.019)PLVS(0.719)S(0.119)S(0.083)DS(0.06)PPRPQPAFK 69.081 3.9584e-06 82273000.0 2626.0 2893.3 2796.4 2575.5 2894.1 2755.4 3087.7 2976.4 1346.8 2287.6 True False 2687.180690693484 2554.551090941323 2416.6642395256836 2125.737273122652 2632.3291659948563 2727.6831777030293 2854.7923030784696 2897.4562032902422 2285.421233619901 2581.235743110963 1.0410442741873835 0.9896620631258269 0.9362431331487242 0.8235347270376264 1.0197941714623533 1.0567353969829831 1.1059789136647433 1.1225073924469073 0.8853981042682527 1.0 11.333846192806794 -6.504318645825902 24.688390059551164 1.0453819768588806 0.9462929140969342 0.20653237048892847 0.07964474612821926 945.0242510899001 1257060.670857718 0.025622558068548452 0.028549434057760587 3.130987647140131e-07 6.504318645825902 -0.0990890627619464 (ac)MEDLDQSPLVS(ph)SSDSPPRPQPAFK ddPTM_A459_Selumetinib_30min_R2 4 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.019)PLVS(0.476)S(0.476)S(0.028)DSPPRPQPAFK;MEDLDQS(0.002)PLVS(0.435)S(0.435)S(0.068)DS(0.061)PPRPQPAFK;MEDLDQS(0.003)PLVS(0.407)S(0.115)S(0.257)DS(0.219)PPRPQPAFK;MEDLDQS(0.156)PLVS(0.484)S(0.07)S(0.048)DS(0.243)PPRPQPAFK 86.575 6.244799999999999e-08 66502300.0 185002.0 74039.9 164177.0 198351.0 120925.0 120181.0 228710.0 168534.0 154712.0 141303.0 True False 174720.32946168366 79718.5222541984 153614.030562402 171335.25162543965 105733.32041678377 136734.8418555038 239345.46818026758 169024.4060376942 185658.72301445992 137223.21524071528 1.2732563448188516 0.5809404925715896 1.1194463727798112 1.248587939911519 0.7705206457326311 0.9964410294252705 1.7442053646710631 1.231747891500674 1.3529687574276676 1.0 17.066165049820597 -7.059366857378694 24.99841486118538 1.3542261641834772 0.9847091609950073 0.28258273182703497 0.2593287338001665 303.865154808061 127951.58214302863 0.09552423904942273 0.07399291339230712 8.72234263092218e-08 7.059366857378694 -0.3695170031884699 (ac)MEDLDQSPLVSS(ph)SDSPPRPQPAFK ddPTM_A459_Selumetinib_30min_R1 3 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.081)PLVS(0.042)S(0.68)S(0.136)DS(0.061)PPRPQPAFK;MEDLDQS(0.007)PLVS(0.053)S(0.528)S(0.182)DS(0.229)PPRPQPAFK;MEDLDQS(0.066)PLVS(0.293)S(0.522)S(0.117)DS(0.002)PPRPQPAFK 103.71 1.7551e-08 426850000.0 12262.699999999999 16564.199999999997 15966.0 14152.9 15625.699999999999 17015.9 15127.5 16507.4 8291.9 13172.699999999999 True False 12548.397050939448 14624.855763512342 13797.904894960317 11681.361697836372 14212.358193941394 16844.73549520106 13986.42049577988 16069.570128407942 14070.748683585423 14863.544357963701 0.8442398898090665 0.9839413407258092 0.9283051580875171 0.7859068750030436 0.9561890388766251 1.1332919719229595 0.9409882433785808 1.0811398507246401 0.9466617345577129 1.0 13.859490561235878 -6.523791589461892 24.999912095666733 1.023214148393322 0.8925951322589448 0.43597026944577255 0.0720921159929836 29.68941322947852 813062.598577166 0.02288619718601929 0.023073993190629662 2.993700918129602e-07 6.523791589461892 -0.1306190161343771 (ac)MEDLDQSPLVSS(ph)SDSPPRPQPAFK ddPTM_A459_Selumetinib_30min_R2 1 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.001)PLVS(0.06)S(0.571)S(0.209)DS(0.159)PPRPQPAFK 58.924 0.0012223 0.0 13570.0 5715.8 9693.5 13959.0 9792.9 7204.6 13248.0 11004.0 6948.7 7736.2 True False 12815.833725014047 6154.183480806262 9069.830763484799 12057.760119381885 8562.628352363216 8196.968253152852 13864.058250413975 11036.019818189729 8338.634162899954 7512.835804938471 1.7058583546561361 0.8191558607950523 1.2072446409014899 1.6049545647538128 1.1397331945860811 1.0910618128729335 1.8453828368378031 1.4689552793015037 1.1099183290307844 1.0 12.875141856781033 -7.140755394592671 19.85606684465444 1.4056007652639417 1.2488920004325157 0.010513427061137337 0.31753328757319693 13.752707748441413 2204.573633380514 0.11965086275340517 0.09268126124632131 7.231770001154667e-08 7.140755394592671 -0.15670876483142604 (ac)MEDLDQSPLVSSS(ph)DSPPRPQPAFK ddPTM_A459_Selumetinib_30min_R2 1 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.049)PLVS(0.05)S(0.297)S(0.54)DS(0.064)PPRPQPAFK 49.37 3.8005e-05 22195000.0 28552.0 12455.0 27686.0 30473.0 20642.0 21235.0 34794.0 26563.0 26720.0 19442.0 True False 26965.194142711956 13410.25845086287 25904.7129022376 26322.52483114291 18048.76741817863 24159.928497862576 36411.98994300301 26640.29393225863 32064.746619178677 18880.6589436175 1.4281913689155106 0.7102643234491628 1.3720237720301884 1.3941528688034 0.9559394866501687 1.2796125691380968 1.9285338531742229 1.4109832719193431 1.6982853572500964 1.0 14.204621495843476 -7.015514617784682 24.187465134904855 1.5523241232543898 1.1646853972253053 0.21468884877037242 0.30050472590068605 602.739129830903 939675.9694732565 0.10672676321323797 0.0854703706880846 9.649068337560128e-08 7.015514617784682 -0.38763872602908456 (ac)MEDLDQSPLVSSSDS(ph)PPRPQPAFK ddPTM_A459_Selumetinib_30min_R1 2 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.007)PLVS(0.059)S(0.401)S(0.102)DS(0.432)PPRPQPAFK;MEDLDQS(0.009)PLVS(0.025)S(0.044)S(0.044)DS(0.879)PPRPQPAFK 71.308 4.7025e-05 269591000.0 3228.2 4336.4 3992.5 3723.3999999999996 3724.8 4170.3 3747.1 4045.5 2193.45 3219.5 True False 3303.4107790162643 3828.6922720623347 3450.340429232686 3073.1780868743467 3387.8924976668513 4128.35056832944 3464.453230192484 3938.2001983640243 3722.124446750498 3632.7541855856575 0.9093405747418338 1.053936511106129 0.9497863750107927 0.8459636765593326 0.9325961308116061 1.1364244199924813 0.9536712513990152 1.084081112339046 1.0246012409866463 1.0 11.826848032129034 -6.710849403354987 24.99969483684294 1.0396307429909604 0.9402529459809466 0.3716735327802857 0.06591654254309173 122.22834087804846 60400.152893615996 0.021963646086526522 0.021963620797908985 1.946034774749489e-07 6.710849403354987 -0.09937779701001381 (ac)MEDLDQSPLVSSSDS(ph)PPRPQPAFK ddPTM_A459_Selumetinib_30min_R2 5 MEDLDQSPLVSSSDSPPRPQPAFK 24 1 Q9NQC3-5;Q9NQC3;Q9NQC3-2;Q9NQC3-4 Q9NQC3-5 RTN4 Reticulon-4 1 MEDLDQS(0.029)PLVS(0.043)S(0.182)S(0.202)DS(0.544)PPRPQPAFK;MEDLDQSPLVS(0.004)S(0.009)S(0.037)DS(0.951)PPRPQPAFK;MEDLDQS(0.002)PLVS(0.019)S(0.07)S(0.133)DS(0.776)PPRPQPAFK;MEDLDQS(0.001)PLVS(0.011)S(0.035)S(0.004)DS(0.948)PPRPQPAFK;MEDLDQS(0.001)PLVS(0.018)S(0.018)S(0.055)DS(0.91)PPRPQPAFK 73.839 3.525e-07 108616000.0 238841.0 87549.8 182940.0 242049.0 151939.1 148985.6 271697.0 203478.2 185160.0 164348.0 True False 225567.17337627732 94264.58814302308 171169.83957001145 209081.5086421849 132851.15190521194 169507.0140433792 284331.4488573916 204070.28787437064 222197.17380266145 159602.84621261482 1.4133029499723844 0.5906197187577005 1.072473603271383 1.310011153332799 0.8323858568802361 1.0620550827619362 1.7814935986706633 1.2786130869027144 1.3921880409742922 1.0 17.284126853943256 -7.039143674167916 24.601011720987668 1.3913605691876407 1.0261961711783918 0.23245395258072887 0.2789109252289611 574.5709137783863 361104.443615011 0.10206073148047301 0.07907252452610591 9.138108827181763e-08 7.039143674167916 -0.36516439800924894 (ac)MEDMNEY(ph)SNIEEFAEGSK ddPTM_A459_Selumetinib_30min_R1 1 MEDMNEYSNIEEFAEGSK 18 0 O14979-3;O14979-2;A0A087WU03 O14979-3 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 MEDMNEY(0.539)S(0.461)NIEEFAEGSK 72.937 0.0012485 1006000.0 681.57 702.27 1053.7 1099.2 859.53 1013.6 961.0 842.6 543.42 1069.2 True False 697.4492548956433 620.0479019235345 910.613327559795 907.2453545394753 781.7856632623467 1003.4041042751657 888.5109962944609 820.2515108494688 922.1440501735417 1206.442234889946 0.5781041435102494 0.5139474431447574 0.7547923151437608 0.7520006580524231 0.6480091965063398 0.8317050541310818 0.7364720585859734 0.6798929009015453 0.7643499402668554 1.0 10.236543124846584 -14.522878745065224 0.044080594876934415 2.270639075179793 2.183158236398099e-12 0.6573457186618313 0.07505096746072039 479.31214106055836 1.5663067453601867 77.08080486431862 20.455298912917122 3.000000001485951e-15 14.522878745065224 -2.27063907517761 (ac)MEDMNEYSNIEEFAEGSK ddPTM_A459_Selumetinib_30min_R1 2 MEDMNEYSNIEEFAEGSK 18 0 O14979-3;O14979-2;A0A087WU03 O14979-3 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 ; 193.23 1.0217999999999999e-17 4731000.0 1907.12 2066.79 2489.27 2319.0299999999997 2098.41 2132.6000000000004 2254.62 1789.08 1068.05 1666.65 False True 1951.5521853904634 1824.8092659753954 2151.2408065813524 1914.054944084496 1908.6091860043762 2111.1479802458744 2084.5521981950255 1741.627786649143 1812.402842714386 1880.5807620457624 1.0377390988874606 0.9703434719763395 1.1439236484803537 1.0177999172991214 1.014904132023622 1.1226042629242323 1.1084619391338322 0.9261116681607114 0.9637463486241292 1.0 10.876962549296618 -7.767617361280366 24.999986439136453 0.9586967451541123 1.058342495299647 0.40446188916453596 0.05334589915208413 152.40833398500183 616727.1186923732 0.028932200472329597 0.014438889287186115 1.7075862092813383e-08 7.767617361280366 0.09964575014553467 (ac)MEDS(ph)MDMDMSPLRPQNYLFGCELK ddPTM_A459_Selumetinib_30min_R1 16 MEDSMDMDMSPLRPQNYLFGCELK 24 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 MEDS(0.502)MDMDMS(0.449)PLRPQNY(0.048)LFGCELK;MEDS(0.639)MDMDMS(0.352)PLRPQNY(0.01)LFGCELK;MEDS(0.499)MDMDMS(0.499)PLRPQNY(0.002)LFGCELK;MEDS(0.99)MDMDMS(0.01)PLRPQNYLFGCELK;MEDS(0.511)MDMDMS(0.489)PLRPQNYLFGCELK;MEDS(0.509)MDMDMS(0.486)PLRPQNY(0.005)LFGCELK;MEDS(0.741)MDMDMS(0.142)PLRPQNY(0.116)LFGCELK;MEDS(0.769)MDMDMS(0.157)PLRPQNY(0.073)LFGCELK;MEDS(0.88)MDMDMS(0.107)PLRPQNY(0.013)LFGCELK;MEDS(0.472)MDMDMS(0.465)PLRPQNY(0.064)LFGCELK;MEDS(0.509)MDMDMS(0.485)PLRPQNY(0.007)LFGCELK;MEDS(0.517)MDMDMS(0.482)PLRPQNY(0.001)LFGCELK;MEDS(0.535)MDMDMS(0.451)PLRPQNY(0.015)LFGCELK;MEDS(0.518)MDMDMS(0.476)PLRPQNY(0.006)LFGCELK;MEDS(0.499)MDMDMS(0.499)PLRPQNY(0.003)LFGCELK;MEDS(0.812)MDMDMS(0.185)PLRPQNY(0.003)LFGCELK 69.548 1.3794e-05 351009900.0 45600.450000000004 52113.85 56188.47999999999 61468.23 48971.06999999999 45953.18 49719.079999999994 43287.78 28286.120000000006 40499.969999999994 True False 46662.851761970225 46012.336214928415 48558.39303722783 50733.95753208155 44541.64536504463 45490.93273134907 45968.72976653906 42139.64745587397 47999.47970353471 45698.53565261483 1.0211016851105648 1.0068667531209095 1.0625809414628224 1.1101878169082775 0.974684302876475 0.9954571209273775 1.0059125333025583 0.9221224893551436 1.0503504985019847 1.0 15.479860316374191 -6.301013329899542 24.98437490965332 0.9884536402227724 1.0479757155591725 0.3478213369834918 0.03924747228104395 599.0081918310334 378172.7544478768 0.012271015339879189 0.013914202141620362 5.000191875385331e-07 6.301013329899542 0.05952207533640008 (ac)MEDS(ph)MDMDMSPLRPQNYLFGCELK ddPTM_A459_Selumetinib_30min_R2 20 MEDSMDMDMSPLRPQNYLFGCELK 24 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 MEDS(0.995)MDMDMS(0.005)PLRPQNYLFGCELK;MEDS(0.996)MDMDMS(0.003)PLRPQNY(0.001)LFGCELK;MEDS(0.602)MDMDMS(0.378)PLRPQNY(0.02)LFGCELK;MEDS(0.495)MDMDMS(0.475)PLRPQNY(0.03)LFGCELK;MEDS(0.534)MDMDMS(0.46)PLRPQNY(0.006)LFGCELK;MEDS(0.848)MDMDMS(0.152)PLRPQNYLFGCELK;MEDS(0.529)MDMDMS(0.463)PLRPQNY(0.008)LFGCELK;MEDS(0.509)MDMDMS(0.482)PLRPQNY(0.01)LFGCELK;MEDS(0.742)MDMDMS(0.258)PLRPQNYLFGCELK;MEDS(0.604)MDMDMS(0.205)PLRPQNY(0.192)LFGCELK;MEDS(0.518)MDMDMS(0.467)PLRPQNY(0.015)LFGCELK;MEDS(0.51)MDMDMS(0.483)PLRPQNY(0.007)LFGCELK;MEDS(0.5)MDMDMS(0.5)PLRPQNY(0.001)LFGCELK;MEDS(0.522)MDMDMS(0.475)PLRPQNY(0.003)LFGCELK;MEDS(0.444)MDMDMS(0.489)PLRPQNY(0.067)LFGCELK;MEDS(0.79)MDMDMS(0.178)PLRPQNY(0.032)LFGCELK;MEDS(0.513)MDMDMS(0.485)PLRPQNY(0.002)LFGCELK;MEDS(0.521)MDMDMS(0.479)PLRPQNY(0.001)LFGCELK;MEDS(0.868)MDMDMS(0.113)PLRPQNY(0.02)LFGCELK;MEDS(0.988)MDMDMS(0.012)PLRPQNYLFGCELK 85.35 1.2528e-05 438653400.0 876950.8 886483.6000000001 928494.8 1017607.0 965607.6 775222.7 722471.6 767261.8 648568.78 863272.8300000001 True False 828213.3852481992 954474.0416259624 868756.4554367034 879007.1711300102 844299.3406465295 882002.5901539894 756067.9609503159 769494.4048109705 778300.6585258167 838347.9003457215 0.9879113252465439 1.138517841140119 1.0362720000592138 1.0484992814647969 1.0070990102060895 1.0520722838218661 0.9018546603844602 0.9178700208990124 0.9283743159669843 1.0 19.677189536912884 -7.2543048805598245 24.85763375099194 0.9301805832925408 1.047341066640806 0.5884015686359056 0.044093871369083874 328.1467006252929 1143313.142813345 0.016604185095322018 0.01258580095610444 5.567947343167662e-08 7.2543048805598245 0.11716048334826523 (ac)MEDSMDMDMS(ph)PLRPQNYLFGCELK ddPTM_A459_Selumetinib_30min_R1 1 MEDSMDMDMSPLRPQNYLFGCELK 24 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 MEDS(0.494)MDMDMS(0.474)PLRPQNY(0.032)LFGCELK 50.53100000000001 0.0029408 12635000.0 4069.9 4499.0 4767.1 5178.1 4326.3 4336.5 4491.6 4884.7 2670.5 3579.1 True False 4164.7207513531675 3972.2549884716427 4119.754003805922 4273.842039975305 3934.986928870303 4292.878747226969 4152.794995792093 4755.14188825825 4531.643454397048 4038.5123483862794 1.0312512113569043 0.9835936220571142 1.0201167282432864 1.0582713809660775 0.9743654567362302 1.0629851729789386 1.0282982042760074 1.1774488915846262 1.1221071185303706 1.0 11.979608235348055 -7.64973315986121 8.967326579442739 1.112110760350862 1.0216714825391255 0.3368743530921665 0.04875954463534975 0.24689728395758706 18.439509124181953 0.021927196062453743 0.012619359808749207 2.2400970810308107e-08 7.64973315986121 -0.09043927781173644 (ac)MEDSMDMDMS(ph)PLRPQNYLFGCELK ddPTM_A459_Selumetinib_30min_R2 1 MEDSMDMDMSPLRPQNYLFGCELK 24 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 MEDS(0.494)MDMDMS(0.5)PLRPQNY(0.007)LFGCELK 51.503 0.0095813 14870000.0 33168.0 37580.0 31973.0 40408.0 35095.0 25564.0 28171.0 37244.0 23775.0 29759.0 True False 31324.65534202402 40462.265161254676 29915.891989570264 34904.360692311966 30686.052346719265 29085.208953113204 29481.007319777516 37352.37387392389 28530.664329003477 28899.780346832296 1.0839063469026509 1.4000890205966476 1.0351598396438797 1.2077725253762295 1.0618091894972745 1.0064162635167306 1.0201118128224433 1.2924795076519702 0.9872277223771606 1.0 14.818770907094088 -5.2907176290919615 24.96073627977531 1.0864828483597686 1.2419978179066293 0.23719424639762676 0.11769496820611966 858.3836648436059 731800.857642924 0.029454199695083467 0.06132991993380579 5.120146305705849e-06 5.2907176290919615 0.15551496954686073 (ac)MEGAAAPVAGDRPDLGLGAPGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 MEGAAAPVAGDRPDLGLGAPGSPR 24 1 O60285;O60285-2 O60285 NUAK1 NUAK family SNF1-like kinase 1 1 MEGAAAPVAGDRPDLGLGAPGS(1)PR 61.985 2.1691e-06 6375300.0 54.668 138.8 111.79 121.74 142.52 53.972 0.0 121.95 0.0 121.74 True False 55.94165803458928 122.54923147363064 96.60953201851524 100.48039434282722 129.62909116394968 53.429090682655115 0.0 118.71548985057288 0.0 137.36651484801914 0.407243774776426 0.8921332219079579 0.703297540346008 0.7314766226252276 0.943673145579692 0.38895280077367106 0.0 0.8642243707057607 0.0 1.0 7.101886558193959 -6.782384531541749 24.900201396524533 0.4139846130333223 0.74224335637174 0.1552721820865327 0.3265610882140833 371.1351011151735 441212.99783103436 0.10763895212508195 0.09502642202193566 1.6504997711842265e-07 6.782384531541749 0.3282587433384177 (ac)MEGAAAPVAGDRPDLGLGAPGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 MEGAAAPVAGDRPDLGLGAPGSPR 24 1 O60285;O60285-2 O60285 NUAK1 NUAK family SNF1-like kinase 1 1 MEGAAAPVAGDRPDLGLGAPGS(1)PR 50.87300000000001 0.00087631 3497400.0 0.0 607.05 0.0 661.2 659.12 0.0 0.0 0.0 0.0 0.0 True False 0.0 653.6087830266002 0.0 571.1434193663803 576.3154529924374 0.0 0.0 0.0 0.0 0.0 0.0 (ac)MEGIS(ph)NFKTPSK ddPTM_A459_Selumetinib_30min_R2 2 MEGISNFKTPSK 12 1 Q96KB5;Q96KB5-2;E5RIE1 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 MEGIS(0.997)NFKT(0.002)PSK;MEGIS(0.992)NFKT(0.007)PSK 106.18 0.0021758000000000003 61805000.0 247450.0 230290.0 231540.0 280520.0 243520.0 224690.0 252990.0 221720.0 182233.0 254410.0 True False 233697.71962083442 247952.50250093994 216642.96848169112 242312.6920760082 212926.84050357828 255639.007967259 264754.5362901744 222365.16849227803 218684.69201544876 247064.5222634361 0.945897522962244 1.0035941228200989 0.8768679796555024 0.9807668452601171 0.8618268562110345 1.0347054511318312 1.0716007861617463 0.9000287311796955 0.8851319081024229 1.0 17.91452833322439 -6.778404692038879 24.999967798175803 0.9778768515317215 0.9371160172003625 0.10249222219874743 0.06547152171303358 714.2736519580412 1052541.8250897888 0.024216225290722086 0.021410653130627275 1.6656943321118942e-07 6.778404692038879 -0.04076083433135902 (ac)MEGSGEQPGPQPQHPGDHR ddPTM_A459_Selumetinib_30min_R1 1 MEGSGEQPGPQPQHPGDHR 19 0 Q9UJA5-3;Q9UJA5-2;Q9UJA5 Q9UJA5-3 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 47.752 0.026799 14020000.0 189.52 308.24 422.14 431.76 328.26 324.83 353.07 348.93 285.0 159.31 False True 193.93544725827462 272.15111750311166 364.81570664903865 356.3612211389772 298.56894095901 321.562505122042 326.4376456417122 339.67524291562444 483.62418442357597 179.7589903108094 1.0788636881134772 1.5139777823215026 2.029471271607945 1.9824389340572985 1.6609402425034439 1.7888535342018195 1.8159739608978134 1.8896147687985698 2.6904033205091626 1.0 7.4899201159467985 -4.942535952808525 2.9492057080990812 1.8812262675310494 1.0607415344927007 0.2767554386617671 0.39140124929643316 0.363958792456753 5.6618074660689395 0.09664692718036846 0.5970573034599531 1.1414688048961196e-05 4.942535952808525 -0.8204847330383487 (ac)MEITIRNS(ph)PYR ddPTM_A459_Selumetinib_30min_R1 2 MEITIRNSPYR 11 1 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;A0A087X1I0;Q9UQ88-9;A0A087WYI9 P21127 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 MEITIRNS(1)PYR;MEITIRNS(1)PYR 147.62 6.4007e-05 16592700.0 728.3299999999999 784.98 981.05 1104.51 796.29 947.44 1014.92 833.8399999999999 473.3 705.69 True False 745.2986719165214 693.0741766726982 847.8287985219099 911.6280627205198 724.2657100964177 937.9096138066919 938.3637672832201 811.7238545059589 803.1555315357137 796.2721855026994 0.9359848120853328 0.8703985763801977 1.064747474491605 1.144869906695277 0.9095705253589602 1.1778756446384908 1.1784459941807663 1.0194050090968638 1.008644463737822 1.0 9.637117853650835 -5.269838238489762 23.66282644082183 1.0693158757168624 0.9031916913927736 0.3730830608390828 0.0825045759826426 268.2816807384506 755857.4912003113 0.021850125210925646 0.046817784018105886 5.372318616680517e-06 5.269838238489762 -0.16612418432408882 (ac)MERPEEGKQS(ph)PPPQPWGR ddPTM_A459_Selumetinib_30min_R2 1 MERPEEGKQSPPPQPWGR 18 2 F5GWH4;Q96EP1-2;Q96EP1-4;Q96EP1;Q96EP1-5;Q96EP1-3 F5GWH4 CHFR E3 ubiquitin-protein ligase CHFR 1 MERPEEGKQS(1)PPPQPWGR 42.31399999999999 0.030775 7013800.0 25488.0 22910.0 26490.0 25175.0 22844.0 16232.0 22333.0 28324.0 16453.0 24322.0 True False 24071.478996548107 24667.12333273933 24785.662240131267 21746.121570702682 19974.132492048855 18467.810660574785 23371.52875199997 28406.41815070937 19744.05973523003 23619.7606638548 1.0191245939839082 1.0443426452871432 1.0493612781631882 0.92067493317071 0.8456534668708633 0.7818796694598174 0.9894904984268237 1.2026547836354484 0.8359127772807734 1.0 14.527706725706231 -5.758670504727521 24.717343841167946 0.939519862538428 1.038282841796526 0.14354963052136005 0.10985093858596805 136.27500141739276 1216474.3970042637 0.03269244519234234 0.05350666669083982 1.743128867849754e-06 5.758670504727521 0.09876297925809796 (ac)MERS(ph)PPQSPGPGK ddPTM_A459_Selumetinib_30min_R1 1 MERSPPQSPGPGK 13 1 Q86VQ6 Q86VQ6 TXNRD3 Thioredoxin reductase 3 1 MERS(0.998)PPQS(0.002)PGPGK 67.997 0.011054 6680100.0 2159.5 2688.0 3413.9 3856.2 2908.8 2886.9 2685.3 2879.0 1691.5 2579.7 True False 2209.8121483444697 2373.287710382702 2950.311131210388 3182.7870598390878 2645.6995535903498 2857.860407095475 2482.745659052566 2802.639567690034 2870.351957727995 2910.829623405905 0.7591691834435887 0.8153303413223355 1.0135636615372516 1.093429527529327 0.9089159778766674 0.9818027081061338 0.8529340360867821 0.9628318831009834 0.9860941137356752 1.0 11.507214682810204 -5.1419973052558765 4.48714568575117 0.9710367431322803 0.7725126143850387 0.6113049236300407 0.06033910176313175 0.1541238262599905 4.86422811898792 0.01652428305801457 0.04865542053647933 7.2111195358046065e-06 5.1419973052558765 -0.19852412874724157 (ac)MES(ph)GAYGAAK ddPTM_A459_Selumetinib_30min_R1 1 MESGAYGAAK 10 0 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 MES(0.994)GAY(0.006)GAAK 46.844 0.019578 2656100.0 4090.7 3511.7 4952.8 4257.5 4773.5 4273.5 4117.9 5111.3 2479.5 3569.3 True False 4186.005350883412 3100.548531454961 4280.236963783007 3514.0075481730487 4341.737767829875 4230.512470027544 3807.2834876596894 4975.731720157715 4207.530404485109 4027.4544229261933 1.0393675287930437 0.7698531642729856 1.0627648420843336 0.8725132997581897 1.078035233152393 1.0504184593487755 0.9453324824700223 1.2354532659223838 1.0447121091014309 1.0 11.97565254728967 -6.274890995115879 24.39738186956634 1.064652952046225 0.9332938935949612 0.2521529355142863 0.10333971684715111 743.0297616379885 1347640.400694306 0.030780518288127737 0.03510237273094319 5.310177092451706e-07 6.274890995115879 -0.13135905845126372 (ac)MES(ph)GAYGAAK ddPTM_A459_Selumetinib_30min_R2 1 MESGAYGAAK 10 0 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 MES(0.996)GAY(0.004)GAAK 50.878 0.023562 1898800.0 69223.0 31788.0 55475.0 58341.0 55009.0 34456.0 56521.0 48592.0 45509.0 45771.0 True False 65375.86278162467 34226.03738547001 51905.79889661313 50394.855156161495 48098.27763330045 39202.00123957396 59149.33849423677 48733.39467516133 54612.07162770217 44449.47230266005 1.470790526746305 0.7699987336727454 1.167748371525816 1.133755982816148 1.0820888334915517 0.8819452562371127 1.3307095771910213 1.0963773505190728 1.2286326203344815 1.0 15.439878671251188 -7.274880186900997 24.97181262032431 1.1719612988577948 1.076026125711985 0.038465448576064265 0.19043052403107677 2598.9834358494304 4828657.419853169 0.07466315538998343 0.05065931861066117 5.3103092475944536e-08 7.274880186900997 -0.0959351731458098 (ac)MES(ph)PTKEIEEFESNSLK ddPTM_A459_Selumetinib_30min_R1 4 MESPTKEIEEFESNSLK 17 1 Q14123;Q14123-2;F8W905 Q14123 PDE1C Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C 1 MES(0.838)PT(0.162)KEIEEFESNSLK;MES(0.5)PT(0.5)KEIEEFESNSLK;MES(0.5)PT(0.5)KEIEEFESNSLK;MES(0.5)PT(0.5)KEIEEFESNSLK 107.97 3.4725e-12 24811600.0 10168.8 12784.800000000001 14859.6 15018.1 12042.6 11974.599999999999 11881.7 11398.7 7717.389999999999 11232.130000000001 True False 10405.7132549596 11287.949672507732 12841.747937940141 12395.470759651826 10953.348956293721 11854.146396066884 10985.453802988455 11096.369447804223 13095.847174135646 12673.883295711203 0.821035906057369 0.8906464900404704 1.0132449256721294 0.9780325785267732 0.8642456854561928 0.9353207789185092 0.8667788353949807 0.8755303476369548 1.0332939690684413 1.0 13.629571015558069 -8.267083582444954 24.972391907246536 1.016646999294797 0.9094258641398741 0.3962290593512776 0.054666667942756146 550.1935679132934 2434254.7995838826 0.05081396863719878 0.014613904839109425 5.40650261712181e-09 8.267083582444954 -0.10722113515492293 (ac)MES(ph)PTKEIEEFESNSLK ddPTM_A459_Selumetinib_30min_R2 1 MESPTKEIEEFESNSLK 17 1 Q14123;Q14123-2;F8W905 Q14123 PDE1C Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C 1 MES(0.456)PT(0.456)KEIEEFES(0.088)NSLK 59.11600000000001 0.002158 0.0 3120.7 4132.7 3939.6 3985.6 2606.2 2740.6 4421.9 3398.6 3247.5 4542.3 True False 2947.2639871519036 4449.66480127507 3686.130425112158 3442.75440445651 2278.7858562763854 3118.092773310203 4627.5271118286255 3408.4893633314823 3897.0907427313896 4411.151996687266 0.6681392954414791 1.0087307815774036 0.8356389505236744 0.7804660567221413 0.5165965394046119 0.7068658653458012 1.0490518384548653 0.7726982352662584 0.8834632643939879 1.0 12.10693975742251 -8.374267306654977 0.7920491111991588 0.9897939850660928 0.7784665227405726 0.18519218893048628 0.14454639393266489 1.2508670535963662 1.758495253001492 0.14855845540183307 0.05652776265951277 4.224085433339234e-09 8.374267306654977 -0.21132746232552024 (ac)MESPT(ph)KEIEEFESNSLK ddPTM_A459_Selumetinib_30min_R2 1 MESPTKEIEEFESNSLK 17 1 Q14123;Q14123-2;F8W905 Q14123 PDE1C Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C 1 MES(0.131)PT(0.869)KEIEEFESNSLK 78.324 0.015634000000000002 0.0 3777.3 3764.1 2016.8 3196.9 3241.4 2590.9 3731.7 3584.5 2135.4 4260.4 True False 3567.3727877299584 4052.7943665108746 1887.041283725811 2761.4767050398973 2834.186353516337 2947.772957151504 3905.2314442232687 3594.930301554078 2562.539668061157 4137.391182151427 0.8622275802973358 0.9795531019630196 0.45609448095370986 0.6674439480010543 0.6850177391354548 0.7124714167391526 0.9438874093100774 0.8688881817756302 0.6193612243183269 1.0 12.014505652645992 -7.229965537121364 23.838687038601595 0.8471082371236585 0.7216606080559272 0.14113850379775206 0.15692187373035932 852.0131907037676 645325.7951894968 0.06251525963163146 0.048417749236213836 5.8889038413863624e-08 7.229965537121364 -0.12544762906773121 (ac)MESRDPAQPMSPGEAT(ph)QSGARPADR ddPTM_A459_Selumetinib_30min_R1 2 MESRDPAQPMSPGEATQSGARPADR 25 2 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 MESRDPAQPMS(0.204)PGEAT(0.793)QS(0.003)GARPADR;MESRDPAQPMS(0.083)PGEAT(0.909)QS(0.009)GARPADR 69.581 3.1857e-06 19418400.0 331.84000000000003 444.57000000000005 234.95 637.22 224.8 298.49 288.01 144.57 237.68 410.4 True False 339.57122635176154 392.5195377250141 203.04508048796984 525.9414891008408 204.46687969166356 295.48746160723573 266.28517382181866 140.73553397045777 403.32560053963323 463.0788376345249 0.7332903142072773 0.8476300487624567 0.43846763010193707 1.1357493505585952 0.44153794791424844 0.6380932091749848 0.5750320510910035 0.30391268728529175 0.8709653038775859 1.0 8.85511401821056 (ac)MET(ph)MASPGKDNYR ddPTM_A459_Selumetinib_30min_R1 4 METMASPGKDNYR 13 1 S4R3E5;O60684 S4R3E5 KPNA6 Importin subunit alpha-7 1 MET(0.955)MAS(0.045)PGKDNYR;MET(0.994)MAS(0.006)PGKDNYR;MET(1)MASPGKDNYR;MET(0.97)MAS(0.03)PGKDNYR 132.88 0.00063686 126069200.0 13745.0 14574.099999999999 17104.5 17623.0 14442.199999999999 13512.599999999999 13797.8 13091.3 8795.72 12598.900000000001 True False 14065.231756885742 12867.757596684727 14781.80284829317 14545.47387468083 13135.905559977507 13376.675512459155 12757.020837327493 12744.076197464583 14925.694426028542 14216.091538678409 0.9893880971867538 0.90515438520319 1.0397937300892865 1.0231696831091903 0.9240166697181158 0.9409531076853709 0.8973648490247019 0.8964542865239126 1.0499154697632245 1.0 13.79523725570033 -6.276131488736827 24.427610417293515 0.9430442699270067 0.9869618461374364 0.09079290258109796 0.054854017208179076 1296.2517597326978 2155186.4375189175 0.017238050755094582 0.019639732275737596 5.295031051395423e-07 6.276131488736827 0.04391757621042969 (ac)MET(ph)MASPGKDNYR ddPTM_A459_Selumetinib_30min_R2 5 METMASPGKDNYR 13 1 S4R3E5;O60684 S4R3E5 KPNA6 Importin subunit alpha-7 1 MET(0.952)MAS(0.048)PGKDNYR;MET(0.997)MAS(0.003)PGKDNYR;MET(0.907)MAS(0.093)PGKDNYR;MET(0.999)MAS(0.001)PGKDNYR;MET(0.937)MAS(0.063)PGKDNYR 158.25 0.00038234 44796000.0 326538.0 293982.0 306295.0 333959.0 345984.0 254962.0 268050.0 266025.0 202711.9 276959.0 True False 308390.32519518334 316529.47409888124 286588.31316878006 288473.20808859234 302518.3967837956 290080.70118540316 280514.8561309983 266799.08870719076 243259.94424372353 268962.4740440987 1.1465923872510932 1.1768536678725803 1.0655327074430148 1.0725407293855227 1.1247606115275217 1.078517373906376 1.0429516501436014 0.9919565532530266 0.9044382310516633 1.0 18.037045374776177 -7.532621755840748 1.3765460571587074 0.9508007423574437 1.1156531995811245 0.7482203928390563 0.03841000746762017 0.22755489649599428 0.8194388457615405 0.029125962890174273 0.013505409712628336 2.9334469874610858e-08 7.532621755840748 0.1648524572236808 (ac)MET(ph)PGASASSLLLPAASRPPR ddPTM_A459_Selumetinib_30min_R1 1 METPGASASSLLLPAASRPPR 21 1 Q96DF8;F8WEF8 Q96DF8 DGCR14 Protein DGCR14 1 MET(1)PGASASSLLLPAASRPPR 140.33 8.870100000000002e-08 7242300.0 446.12 496.79 495.32 491.95 596.5 474.22 382.67 480.95 415.99 315.64 True False 456.51372800159106 438.625595848595 428.05826459800494 406.04016754521 542.5466803206284 469.44977735730936 353.80489381061534 468.1936436542275 705.9046472925027 356.1554685939605 1.2817821660968098 1.2315565378799662 1.2018859805463724 1.140064391396784 1.523342270897897 1.318103521505973 0.9934001440645435 1.3145765962897442 1.9820126589078941 1.0 8.476363332112918 -8.020288163832445 24.767490195897192 1.5434357837700015 1.242619067264446 0.12389351826654105 0.2545816945150926 1098.2515372889304 1340720.5776045625 0.15681325538575527 0.06092297788881102 9.543591378509232e-09 8.020288163832445 -0.3008167165055555 (ac)MET(ph)PGASASSLLLPAASRPPR ddPTM_A459_Selumetinib_30min_R2 1 METPGASASSLLLPAASRPPR 21 1 Q96DF8;F8WEF8 Q96DF8 DGCR14 Protein DGCR14 1 MET(0.606)PGAS(0.386)AS(0.005)S(0.002)LLLPAASRPPR 45.347 0.0037299 2102300.0 5693.9 6383.3 6144.8 6841.2 8115.5 5509.8 5170.7 4868.8 3032.4 6953.7 True False 5377.455832487654 6872.878584455477 5749.450257952383 5909.416758271747 7095.958336509479 6268.724937015462 5411.147795547676 4882.96740192677 3638.964732335229 6752.928613117639 0.7963146274109705 1.0177626594637523 0.8514010124117131 0.8750894755192051 1.0507971789788362 0.92829723163938 0.8013038646723528 0.7230888525078664 0.5388720865886987 1.0 12.721297591169014 -7.442453764250063 3.1116651065398595 0.726214245663681 0.9249481622482473 0.2600440621462592 0.1261892995610888 0.29997124706109557 5.624191909340095 0.058605013441842574 0.035502867749943975 3.610324476861703e-08 7.442453764250063 0.1987339165845663 (ac)METMAS(ph)PGKDNYR ddPTM_A459_Selumetinib_30min_R1 3 METMASPGKDNYR 13 1 S4R3E5;O60684 S4R3E5 KPNA6 Importin subunit alpha-7 1 MET(0.014)MAS(0.986)PGKDNYR;MET(0.241)MAS(0.759)PGKDNYR;MET(0.084)MAS(0.916)PGKDNYR 97.631 0.0012751 102587600.0 4272.66 4297.65 5246.0 5308.030000000001 4357.33 4089.86 3879.45 4299.13 2611.57 3897.12 True False 4372.204664850885 3794.479140076717 4533.622014215323 4381.082204563475 3963.2102708490947 4048.7197216957675 3586.819963136885 4185.103106857675 4431.643548473959 4397.353313163403 0.9942809579941562 0.8629006745302925 1.0309887997045863 0.9962997950264263 0.9012717397497471 0.9207174028013608 0.8156770010723949 0.9517322827641889 1.0077979259041816 1.0 12.102419737765494 -4.44430433485021 21.718677716843107 0.9392948514528134 3.7929524179894307 0.049330659699699964 0.06564917513263417 1120.5061249811492 329845.995215061 0.016294315805691507 10191.191252471108 3.5949732663934985e-05 4.44430433485021 2.8536575665366173 (ac)METMAS(ph)PGKDNYR ddPTM_A459_Selumetinib_30min_R2 3 METMASPGKDNYR 13 1 S4R3E5;O60684 S4R3E5 KPNA6 Importin subunit alpha-7 1 METMAS(1)PGKDNYR;MET(0.049)MAS(0.951)PGKDNYR;MET(0.232)MAS(0.768)PGKDNYR 104.94 0.0012727 202161000.0 226145.0 224474.0 248330.0 245231.0 226430.0 182135.0 188817.0 219326.0 160336.0 221091.0 True False 213576.7662301624 241690.4340023283 232352.71816126016 211830.11475292884 197983.83909011664 207222.44299308714 197597.3646337873 219964.20234862604 192407.68016214948 214707.52836659472 0.9947334769999232 1.125672843616655 1.0821824457153537 0.9865984502939602 0.9221094416031663 0.9651382257974325 0.9203094373868751 1.0244829513991518 0.8961384895346094 1.0 17.712013252250806 -5.867220284170102 4.167557150360008 0.9547357238271725 1.073299173263054 0.5361286304808839 0.046738046390771934 0.1511372337383466 4.736008695174607 0.012660985513019233 0.019604491965293406 1.357624653403602e-06 5.867220284170102 0.11856344943588137 (ac)MEVAEPS(ph)SPTEEEEEEEEHSAEPR ddPTM_A459_Selumetinib_30min_R2 1 MEVAEPSSPTEEEEEEEEHSAEPR 24 0 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 MEVAEPS(0.493)S(0.493)PT(0.014)EEEEEEEEHSAEPR 80.293 1.0517e-06 2943200.0 1210.0 3174.2 2802.9 2991.4 1173.2 1062.4 2622.1 1004.8 1355.2 2455.5 True False 1142.7530440137798 3417.6509333383315 2622.5644655667757 2583.966159547169 1025.8121274589269 1208.7359564930164 2744.032845592581 1007.7238016464051 1626.2778674517563 2384.603334844809 0.47922144002543327 1.4332156981407365 1.0997906558481993 1.0836041876605589 0.4301814530196013 0.5068918334678423 1.150729266161646 0.42259598773562407 0.6819909389909475 1.0 11.219533586764442 -6.236319564292087 24.292489359076736 0.6828692706465267 1.0586073905047644 0.20493376156155763 0.30989795733397385 764.6055352992727 739422.4067963526 0.08907023324844117 0.11493428553781725 5.803372343240433e-07 6.236319564292087 0.3757381198582377 (ac)MEVAEPS(ph)SPTEEEEEEEEHSAEPRPR ddPTM_A459_Selumetinib_30min_R1 1 MEVAEPSSPTEEEEEEEEHSAEPRPR 26 1 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 MEVAEPS(0.333)S(0.333)PT(0.333)EEEEEEEEHSAEPRPR 45.243 0.0002245 3759000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)MEVAEPSSPT(ph)EEEEEEEEHSAEPRPR ddPTM_A459_Selumetinib_30min_R1 1 MEVAEPSSPTEEEEEEEEHSAEPRPR 26 1 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 MEVAEPS(0.165)S(0.165)PT(0.671)EEEEEEEEHSAEPRPR 64.619 3.0651e-05 6814600.0 176.26 157.43 191.9 150.23 114.16 0.0 134.21 0.0 0.0 57.56800000000001 True False 180.3665150577432 138.99802241277862 165.84103403124678 123.99515066636218 103.83424815658499 0.0 124.0864316469091 0.0 0.0 64.9574135598059 2.7766886822191714 2.13983308132803 2.5530732358756545 1.9088683472934247 1.5984972686910544 0.0 1.9102735907528625 0.0 0.0 1.0 6.0214222840802645 -6.371516247236419 1.4671060452765574 0.5693735524226854 2.4758076780181146 0.6639700554557721 0.5902978654601508 0.24633933442486958 1.068511845234307 0.22786684700263835 0.2863014594738884 4.250928035114407e-07 6.371516247236419 1.9064341255954291 (ac)MEVAEPSSPT(ph)EEEEEEEEHSAEPRPR ddPTM_A459_Selumetinib_30min_R2 1 MEVAEPSSPTEEEEEEEEHSAEPRPR 26 1 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 MEVAEPS(0.17)S(0.17)PT(0.66)EEEEEEEEHSAEPRPR 67.895 5.4805e-05 7255400.0 0.0 0.0 0.0 892.08 0.0 0.0 0.0 0.0 0.0 1023.6 True False 0.0 0.0 0.0 770.5771650761648 0.0 0.0 0.0 0.0 0.0 994.0460083678057 0.0 0.0 0.0 0.7751926556613107 0.0 0.0 0.0 0.0 0.0 1.0 9.957168816721216 -11.658281422861902 2.333043425321601 2.8809959739640956 0.09119912790287259 0.5843922610500165 0.2311677789838552 35686487.27915861 8962576.97430277 355344607.4199929 0.06173339142829916 2.1964361207423714e-12 11.658281422861902 -2.789796846061223 (ac)MEVKPPPGRPQPDS(ph)GR ddPTM_A459_Selumetinib_30min_R1 3 MEVKPPPGRPQPDSGR 16 2 P51991 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 MEVKPPPGRPQPDS(1)GR;MEVKPPPGRPQPDS(1)GR;MEVKPPPGRPQPDS(1)GR 68.26100000000001 0.0063021 61446300.0 7910.6 9717.9 8594.9 9425.3 7858.48 7704.299999999999 9517.6 8510.199999999999 4890.99 8063.14 True False 8094.901588651893 8580.123750270863 7427.759788406269 7779.348289793406 7147.68187152733 7626.801736944709 8799.679769336275 8284.481850974546 8299.65280622409 9098.122560634607 0.889733187776189 0.9430653074948671 0.8164057737081277 0.8550498454981008 0.7856216295055899 0.8382830288464183 0.9671973212814672 0.9105704826201738 0.9122379645812528 1.0 13.151353153939796 -8.111197605334324 0.8085285346449372 0.9860078262168511 0.8585150417882453 0.4130359097437224 0.04963189251637948 0.6529987123716131 0.8756637891479535 0.05108592506984014 0.020366839288640387 7.74109495441336e-09 8.111197605334324 -0.1274927844286058 (ac)MEVKPPPGRPQPDS(ph)GR ddPTM_A459_Selumetinib_30min_R2 5 MEVKPPPGRPQPDSGR 16 2 P51991 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 MEVKPPPGRPQPDS(1)GR;MEVKPPPGRPQPDS(1)GR;MEVKPPPGRPQPDS(1)GR;MEVKPPPGRPQPDS(1)GR;MEVKPPPGRPQPDS(1)GR 80.488 0.0017652999999999996 67897600.0 104921.0 111635.0 117414.0 133514.0 130951.0 98460.0 105752.0 111348.0 99809.0 120436.0 True False 99089.91085204112 120197.04553689924 109859.71107069735 115329.16287550339 114499.7646632066 112021.97126910996 110669.67754361268 111672.00424534632 119773.58889646688 116958.6997496921 0.8472213786927123 1.0276879427878187 0.9393034575949667 0.9860674162958707 0.9789760394759179 0.9577908399191558 0.9462286925253205 0.9547986125387847 1.0240673772263118 1.0 16.83563965223602 -4.746313874965508 24.988173570616098 0.9752476905859325 0.8472210344329638 0.6407048704893008 0.029553322042271554 528.7452671132877 873468.2078905941 0.007041663244575532 0.16274239568921017 1.7934369987043395e-05 4.746313874965508 -0.1280266561529687 (ac)MEVS(ph)PLQPVNENMQVNK ddPTM_A459_Selumetinib_30min_R2 2 MEVSPLQPVNENMQVNK 17 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 MEVS(1)PLQPVNENMQVNK;MEVS(1)PLQPVNENMQVNK 154.15 0.0027827 2813200.0 14075.0 12005.8 16850.8 17168.1 16985.7 13618.4 14081.400000000001 16904.5 10197.7 15751.8 True False 13292.767846689225 12926.606255268529 15766.63787376382 14829.775163375594 14851.804511915345 15494.210984473353 14736.213001764749 16953.689296309367 12237.524947544844 15297.004605908563 0.868978482333385 0.8450416658876828 1.0307009953879376 0.9694561481433758 0.970896256786034 1.0128918297173433 0.9633397767346422 1.1083012480600873 0.7999948527712427 1.0 13.900961557743416 -5.252127269375949 24.76728850874535 0.9854153066238658 0.8570100543925134 0.31645083097136073 0.07330721773267587 623.2167199844829 1657551.2650300637 0.017258664194984858 0.044336121299095255 5.5959358936458005e-06 5.252127269375949 -0.12840525223135235 (ac)MFPTGFSS(ph)PSPSAAAAAQEVR ddPTM_A459_Selumetinib_30min_R2 1 MFPTGFSSPSPSAAAAAQEVR 21 0 A0A669KAX4;Q13620-1;A0A669KAU9 A0A669KAX4 CUL4B Cullin-4B 1 MFPT(0.002)GFS(0.19)S(0.8)PS(0.006)PS(0.002)AAAAAQEVR 124.08 2.1465e-05 1305000.0 1068.5 481.87 0.0 0.0 1070.8 0.0 0.0 707.89 613.22 1026.0 True False 1009.1170475444001 518.8278795437411 0.0 0.0 936.2765309265413 0.0 0.0 709.9498427025015 735.881134798381 996.3767141318568 1.0127866631484297 0.5207145773130557 0.0 0.0 0.939681264773755 0.0 0.0 0.7125315481916706 0.7385571384409102 1.0 9.960547495176186 -7.938665283529305 8.517590523227028 0.8220520855883336 0.34156679556850067 0.25573967129742403 0.3668480495236047 0.3914876324880619 49.08142255856511 0.20879928676900736 0.09982268361908227 1.151687667818727e-08 7.938665283529305 -0.480485290019833 (ac)MGHQQLY(ph)WSHPR ddPTM_A459_Selumetinib_30min_R1 1 MGHQQLYWSHPR 12 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 1 MGHQQLY(0.706)WS(0.294)HPR 53.089 0.024215 10531000.0 2460.9 2693.3 1628.2 2253.2 2987.6 1972.2 2601.9 2187.4 929.51 1988.5 True False 2518.234181922161 2377.9671839188004 1407.0993830624072 1859.7209178023527 2717.3721075036215 1952.3614586143253 2405.6365881982933 2129.383046323437 1577.3105812756423 2243.743344630245 1.122336112081995 1.0598213871518691 0.6271213623563031 0.8288474358054635 1.2110886541488228 0.870135821588838 1.0721531916542475 0.9490314707426336 0.7029817314223938 1.0 11.13169194429608 -5.01994553883791 24.79293976701155 0.9134092766492787 1.106707607993608 0.1763755713799373 0.16065105199342256 1058.9517064146032 1316319.9664908356 0.04190353680732857 0.11441865977133346 9.551123509951829e-06 5.01994553883791 0.19329833134432928 (ac)MHRDS(ph)CPLDCK ddPTM_A459_Selumetinib_30min_R1 1 MHRDSCPLDCK 11 1 A0A087X2D0;P84103-2;P84103 A0A087X2D0 SRSF3 Serine/arginine-rich splicing factor 3 1 MHRDS(1)CPLDCK 63.473 0.016123 16472000.0 1354.7 1588.4 1459.4 1642.1 1438.4 1319.0 1260.5 1178.0 671.15 1093.9 True False 1386.2618742126665 1402.4293895728729 1261.2214959103785 1355.3380610346362 1308.2969739701468 1305.7320575561782 1165.4194701656277 1146.7556133167268 1138.8925311434484 1234.3127204883208 1.1231042597245788 1.1362026545574622 1.021800614200437 1.0980507925887981 1.0599396346272412 1.0578616228143565 0.9441849304644309 0.9290640809916028 0.9226936676897228 1.0 10.269492240851834 -7.172990691325974 2.6090064142517586 0.940549033053985 1.0869830580079958 0.7702562229939405 0.035958311663815204 0.13559960912908486 1.8021559474867712 0.016203292297151024 0.011579378696876143 6.714432444956524e-08 7.172990691325974 0.1464340249540108 (ac)MHRDS(ph)CPLDCK ddPTM_A459_Selumetinib_30min_R2 2 MHRDSCPLDCK 11 1 A0A087X2D0;P84103-2;P84103 A0A087X2D0 SRSF3 Serine/arginine-rich splicing factor 3 1 MHRDS(1)CPLDCK;MHRDS(1)CPLDCK 71.279 0.040742 25992300.0 163130.0 150982.0 166537.0 192104.0 161635.0 128895.0 128122.0 137583.0 118338.0 171739.0 True False 154063.88766113057 162561.8339163532 155822.19073177542 165939.1038021157 141328.96626476623 146649.11625768774 134079.92686892676 137983.34375190828 142008.906639984 166780.44883849035 0.9237526864454331 0.9747055787922574 0.9342953074953835 0.9949553737129618 0.8473952867318923 0.8792944093806959 0.8039307233113956 0.8273352465044084 0.851472145739966 1.0 17.347590650407867 -6.2718605835398815 24.822695140805028 0.8569421860339682 0.9565805518802248 0.3915201196992215 0.053055120017991536 561.43804348403 1337309.8570809846 0.015511608461798335 0.017776811895561427 5.347359918660776e-07 6.2718605835398815 0.09963836584625663 (ac)MIPLEKPGS(ph)GGSSPGATSGSGR ddPTM_A459_Selumetinib_30min_R1 1 MIPLEKPGSGGSSPGATSGSGR 22 1 Q9UEE5 Q9UEE5 STK17A Serine/threonine-protein kinase 17A 1 MIPLEKPGS(0.709)GGS(0.237)S(0.053)PGAT(0.001)SGSGR 77.554 0.00040329 4358900.0 611.42 569.23 899.0 977.55 816.53 798.99 720.68 630.98 527.57 473.6 True False 625.6648963837819 502.58428697215237 776.9207378535219 806.8392433861567 742.6750056700802 790.952886024876 666.318527377203 614.2443606881058 895.2477578117403 534.3911732546565 1.170799458705936 0.9404801428721448 1.4538427592689513 1.5098289114174215 1.389759118113594 1.480100955275245 1.2468741265299277 1.1494283428132082 1.6752667383320023 1.0 9.061752368232456 -5.265379649008433 24.983359263695785 1.3746890862459 1.0556397937795372 0.2943023280522393 0.1897915373539783 349.2282439136581 2214304.0754768103 0.04728771934103365 0.10471209221573277 5.4277564360725025e-06 5.265379649008433 -0.3190492924663628 (ac)MIPLEKPGSGGSS(ph)PGATSGSGR ddPTM_A459_Selumetinib_30min_R1 1 MIPLEKPGSGGSSPGATSGSGR 22 1 Q9UEE5 Q9UEE5 STK17A Serine/threonine-protein kinase 17A 1 MIPLEKPGS(0.288)GGS(0.288)S(0.42)PGAT(0.002)S(0.001)GSGR 73.722 0.00011089 0.0 552.04 636.81 511.05 739.52 673.49 562.55 316.76 548.81 364.27 323.81 True False 564.9014579171483 562.251989155063 441.6522169967102 610.3767145096732 612.5729484143168 556.8912577545328 292.8665381750609 534.2537760138821 618.1395847718451 365.3741676764996 1.5460903038369944 1.5388389188282134 1.2087669465120665 1.6705524596640273 1.6765633769617936 1.5241670238920708 0.801552392270828 1.4622100391259942 1.6917988173677967 1.0 8.513230827345966 (ac)MMEGLDDGPDFLSEEDR ddPTM_A459_Selumetinib_30min_R1 1 MMEGLDDGPDFLSEEDR 17 0 G3V5X9;Q9UNH7;G3V2U1;H0YJF8;G3V4Z5 G3V5X9 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 0 160.86 5.2143e-07 834660.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)MMRS(ph)RSK ddPTM_A459_Selumetinib_30min_R1 1 MMRSRSK 7 2 B8ZZZ9;F8WA32;A0A669KBL0;Q9BZW7-2;Q9BZW7 B8ZZZ9 TSGA10 Testis-specific gene 10 protein 1 MMRS(0.828)RS(0.172)K 47.082 0.045271 0.0 535.06 679.01 719.07 784.73 531.92 676.48 632.81 644.1 435.44 599.58 True False 547.5258569544766 599.5111935368151 621.4242435687788 647.6916367064797 483.80792991810364 669.6752253946962 585.0766322217462 627.0163756683397 738.9098767207078 676.5419334037733 0.8093006950800529 0.8861404798969278 0.9185302682456208 0.9573562328174635 0.7151189099011217 0.9898502847051479 0.8648046829531276 0.9267960265430054 1.0921863675221917 1.0 9.402035547832808 -8.095803107400855 4.38108839574584 1.043581873384869 0.8810565068150353 0.43827607448399286 0.0751859399291061 0.21086792787342212 6.767737302185392 0.052782612512893415 0.018805968178417794 8.020415961284943e-09 8.095803107400855 -0.16252536656983363 (ac)MNLLPNIES(ph)PVTR ddPTM_A459_Selumetinib_30min_R1 6 MNLLPNIESPVTR 13 0 E9PM69;P17980 E9PM69 PSMC3 26S protease regulatory subunit 6A 1 MNLLPNIES(0.941)PVT(0.059)R;MNLLPNIES(0.996)PVT(0.004)R;MNLLPNIES(0.967)PVT(0.033)R;MNLLPNIES(0.957)PVT(0.043)R;MNLLPNIES(0.918)PVT(0.082)R;MNLLPNIES(0.957)PVT(0.043)R 177.38 0.00015019 42452600.0 592.828 541.443 550.8499999999999 536.85 695.5079999999999 949.332 1091.34 343.265 0.0 555.61 True False 606.6397389575159 478.0506018499782 476.0475956024609 443.09922542259574 632.5994242019106 939.7825820044906 1009.0193451571248 334.1604971181377 0.0 626.9279555997036 0.9676386792757063 0.7625287683856543 0.7593338139580738 0.7067785404444727 1.0090464439359412 1.4990280360133534 1.6094661853002266 0.5330125959983522 0.0 1.0 9.292155852784644 -6.273400819403131 23.18164878682483 0.9796583488568897 0.7936215690127079 0.02104215595630432 0.4320728232880515 1271.7055424796029 2464598.458801722 0.14853581650352615 0.16996760157679097 5.328428967013482e-07 6.273400819403131 -0.18603677984418188 (ac)MNLLPNIES(ph)PVTR ddPTM_A459_Selumetinib_30min_R2 1 MNLLPNIESPVTR 13 0 E9PM69;P17980 E9PM69 PSMC3 26S protease regulatory subunit 6A 1 MNLLPNIES(0.871)PVT(0.129)R 106.55 0.00073305 4567600.0 0.0 783.97 3095.6 751.94 0.0 0.0 640.36 0.0 0.0 1081.7 True False 0.0 844.0979781391387 2896.4324662344407 649.5244748311494 0.0 0.0 670.1380088492677 0.0 0.0 1050.4685104058776 0.0 0.8035442945481517 2.757276812719806 0.6183188438273011 0.0 0.0 0.6379420251163372 0.0 0.0 1.0 10.036817200064581 -5.99164187502461 24.997615198196666 0.23500381402506157 1.238466885031417 0.24880518922136186 0.7069814013419061 252.08141366420975 753920.4358188977 0.20278205605363478 0.30022773095796923 1.0194316783980804e-06 5.99164187502461 1.0034630710063555 (ac)MNPVYS(ph)PGSSGVPYANAK ddPTM_A459_Selumetinib_30min_R2 1 MNPVYSPGSSGVPYANAK 18 0 A1KXE4-2;A1KXE4 A1KXE4-2 FAM168B Myelin-associated neurite-outgrowth inhibitor 1 MNPVY(0.443)S(0.553)PGS(0.003)S(0.001)GVPYANAK 78.486 0.0019601 2414000.0 15831.0 16664.0 19202.0 19339.0 18666.0 16566.0 15694.0 15533.0 13620.0 18554.0 True False 14951.176396514173 17942.075216794776 17966.564225556824 16704.994838364222 16321.010203842756 18847.816128824667 16423.802097071042 15578.198458373416 16344.380574596309 18018.29781091859 0.8297774048031425 0.9957697117161852 0.9971288305973932 0.9271128168522921 0.905802000561489 1.0460375517493896 0.9115068620476832 0.8645765888569928 0.9070990359972887 1.0 14.1371751056987 -10.336724351494432 4.260641070533828 1.0000005401087748 0.9353637288911901 0.09655534891690287 0.06179143387651814 87089359.3860178 203017234.1316597 804.2827280730216 0.01569324161289979 4.6054879306063726e-11 10.336724351494432 -0.06463681121758469 (ac)MNTAPS(ph)RPSPTR ddPTM_A459_Selumetinib_30min_R1 1 MNTAPSRPSPTR 12 1 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 MNTAPS(0.597)RPS(0.312)PT(0.091)R 82.705 0.0050039 36925000.0 5905.0 5001.4 5563.6 5836.2 5914.2 4972.6 5013.9 4910.7 3761.2 4651.7 True False 6042.575010870152 4415.833762912219 4808.0936786672455 4817.017229042291 5379.261654236817 4922.580158759555 4635.697486285949 4780.4522837983495 6382.481692820887 5248.791006395028 1.151231779567522 0.8413049324181608 0.9160383167874574 0.9177384321786347 1.0248572762151944 0.9378502883353474 0.8831933831310682 0.9107720764598813 1.2159908224664673 1.0 12.35776943888059 -8.24408535463513 24.979352951814747 1.1079954272176906 0.9423313978248603 0.31230190394012813 0.09475852611299498 768.0981252875537 1105603.8247197594 0.060884972107464116 0.022898039018303607 5.700522253093221e-09 8.24408535463513 -0.16566402939283031 (ac)MNTAPSRPS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 6 MNTAPSRPSPTR 12 1 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 MNTAPS(0.006)RPS(0.857)PT(0.137)R;MNTAPS(0.028)RPS(0.829)PT(0.142)R;MNTAPS(0.024)RPS(0.856)PT(0.12)R;MNTAPS(0.029)RPS(0.826)PT(0.145)R;MNT(0.001)APS(0.11)RPS(0.688)PT(0.202)R;MNTAPS(0.439)RPS(0.514)PT(0.047)R 106.54 0.00054904 585291000.0 1526.17 1814.27 2174.94 2343.9300000000003 1617.75 1401.614 1690.8200000000002 1258.5700000000002 1299.118 1722.33 True False 1561.726791590127 1601.8544249687586 1879.595094090254 1934.6066265153854 1471.4247981369613 1387.5150357236898 1563.280086113008 1225.1886351884839 2204.508362175391 1943.4078324148923 0.8036021907195436 0.8242502671085168 0.9671645152086559 0.9954712511945728 0.757136393913036 0.713959783726689 0.8044014540017909 0.6304331055751977 1.134351897427548 1.0 10.924372973059027 -8.279860271516226 24.99611594221277 1.067175990819665 0.8183880119948135 0.47893822749704806 0.10627833648768222 899.9106959998174 1221116.3886419276 0.10928727755210196 0.028429266120111606 5.2497633724817124e-09 8.279860271516226 -0.24878797882485149 (ac)MNTAPSRPS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 5 MNTAPSRPSPTR 12 1 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 MNTAPS(0.006)RPS(0.792)PT(0.202)R;MNTAPS(0.002)RPS(0.755)PT(0.243)R;MNT(0.001)APS(0.07)RPS(0.783)PT(0.147)R;MNTAPS(0.015)RPS(0.78)PT(0.205)R;MNTAPS(0.146)RPS(0.68)PT(0.174)R 89.46 0.0016165 828358800.0 106336.7 125191.2 138536.4 144790.6 163994.7 109528.2 103759.1 105246.3 121945.0 111646.9 True False 100426.93191353732 134792.96248684564 129623.1188510274 125069.8705022834 143392.21965478055 124614.7153519939 108584.10374475623 105552.54930853705 146337.4074279843 108423.36390351673 0.926248073274177 1.2432095595815913 1.195527552219979 1.1535324675369785 1.3225214058326187 1.1493345240873125 1.0014825203300513 0.9735221774014101 1.3496851800153178 1.0 16.726316147694625 -7.015394229005396 24.22271082357222 1.0784577585986599 1.1793621205681062 0.08155162788611003 0.13646350686564923 1105.9063188987047 1740133.674247757 0.05005692596176543 0.04008794881045284 9.651743482255904e-08 7.015394229005396 0.1009043619694463 (ac)MNY(ph)EGSPIKVTLATLK ddPTM_A459_Selumetinib_30min_R1 1 MNYEGSPIKVTLATLK 16 1 E5RI98 E5RI98 NPM1 1 MNY(0.987)EGS(0.013)PIKVTLATLK 72.089 0.0021193 22876000.0 1398.3 1309.9 1709.7 1825.8 1487.2 985.53 1225.9 1174.8 604.97 1132.1 True False 1430.8776693818347 1156.5362990440108 1477.532130709862 1506.9583045107115 1352.6830225864865 975.6164629896449 1133.429376022248 1143.6404877117925 1026.5899047394055 1277.41606258783 1.1201343957450458 0.9053716583937913 1.1566569217210487 1.1796926221969273 1.0589212569052704 0.7637421287886501 0.8872828589035516 0.8952764265348043 0.8036456835055816 1.0 10.3190127812522 -6.666541342757299 6.998185280234532 0.8650900547530873 1.0859505136396088 0.5853185309880686 0.09026383946653044 0.16107945489784156 10.162868424414565 0.03013019137847592 0.03005044434654273 2.1550564827323612e-07 6.666541342757299 0.2208604588865215 (ac)MQT(ph)PVNIPVPVLR ddPTM_A459_Selumetinib_30min_R1 1 MQTPVNIPVPVLR 13 0 Q9H840 Q9H840 GEMIN7 Gem-associated protein 7 1 MQT(1)PVNIPVPVLR 96.334 0.018234 2874500.0 438.64 443.75 465.74 437.17 393.7 348.32 399.65 272.92 144.27 223.42 True False 448.8594585551374 391.7955437062218 402.49506612669535 360.8264661972549 358.0899045133805 344.81621704925567 369.50407873993925 265.6812750309008 244.81565293610274 252.09813329509154 1.7804949710981335 1.5541390116031066 1.5965809062757232 1.4312936850464189 1.4204385404719402 1.367785681481559 1.465715251082082 1.0538803741157003 0.9711125177175971 1.0 7.977841625321892 -7.236104546545792 0.457719627638988 0.9242481906333001 1.6891925233548701 0.8389340286814895 0.10347936167350293 0.42426124900250733 0.19838437604745635 0.1101968261434054 0.11235285064847268 5.806246284869659e-08 7.236104546545792 0.76494433272157 (ac)MS(ph)GDEMIFDPTMSK ddPTM_A459_Selumetinib_30min_R1 4 MSGDEMIFDPTMSK 14 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 MS(1)GDEMIFDPTMSK;MS(1)GDEMIFDPTMSK;MS(1)GDEMIFDPTMSK;MS(1)GDEMIFDPTMSK 97.911 0.00026981 14009800.0 11091.2 12099.900000000001 12651.900000000001 14479.0 12159.1 10229.599999999999 11714.0 10780.4 6271.3 9179.6 True False 11349.603380281631 10683.238082909102 10933.841471912096 11950.514454491511 11059.311551863466 10126.699511733654 10830.403549004497 10494.468772325672 10641.938062370416 10357.891076875936 1.0957446159691426 1.031410545217984 1.055604986648486 1.1537594251373349 1.067718464094825 0.9776796682426581 1.045618598286233 1.0131858594028516 1.027423245078201 1.0 13.33844267189343 -6.601721134156007 7.599118989098872 1.0159751472858185 1.0822838064008642 0.508479388955285 0.03366849489274672 0.21948131886032485 18.14012100229319 0.011516836788680084 0.011511864215036216 2.501951379862604e-07 6.601721134156007 0.06630865911504569 (ac)MS(ph)PTPPLFSLPEAR ddPTM_A459_Selumetinib_30min_R1 4 MSPTPPLFSLPEAR 14 0 A0A087WWS1;Q96FV9;J3KRD7;J3QQZ3;J3KT14;Q96FV9-2 A0A087WWS1 THOC1 THO complex subunit 1 1 MS(0.999)PT(0.001)PPLFSLPEAR;MS(0.988)PT(0.012)PPLFSLPEAR;MS(0.998)PT(0.002)PPLFSLPEAR;MS(0.975)PT(0.025)PPLFSLPEAR 143.96 2.2769e-05 16671100.0 273.89 547.874 811.89 623.323 630.0699999999999 388.07 421.98 485.61 353.35 421.28 True False 280.2711041028325 483.7286573802877 701.6397973925425 514.4713392718426 573.0802797478933 384.166368139368 390.149708861953 472.73004531641413 599.6091423370898 475.35539161469967 0.5896032927086411 1.0176147486981173 1.476032058896385 1.0822877963459567 1.205582791017136 0.8081666368281247 0.8207537260420719 0.9944770873653759 1.261391272538893 1.0 8.892862713762208 -6.747951887428777 24.989345006086438 0.9668497711385945 1.0938497756831347 0.03688852188101821 0.2353505725728075 783.4047007760221 1451473.4088899067 0.08213982038362821 0.08169505482829524 1.7866854987849863e-07 6.747951887428777 0.1270000045445402 (ac)MS(ph)VMQSGT(ph)QMIK ddPTM_A459_Selumetinib_30min_R1 1 MSVMQSGTQMIK 12 0 Q4KWH8-2 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 2 MS(0.891)VMQS(0.117)GT(0.992)QMIK 59.294 0.031452 24936000.0 5056.6 5657.5 1124.1 1726.5 9288.3 2257.6 7552.6 4651.3 395.34 1274.1 True False 5174.408941569182 4995.117269899603 971.4533942393148 1424.9991854188534 8448.17490498255 2234.8905937367917 6982.901301366859 4527.932414448294 670.8631055088297 1437.6431457849624 3.5992304187169633 3.4745181963582743 0.6757263769437686 0.9912050772800052 5.876406067633559 1.5545516982356058 4.857186793426508 3.149552396033589 0.4666409097944359 1.0 10.489489896672065 -5.040675369869618 24.911171452615942 2.5097651420326885 3.568060260250682 0.06445041210446911 1.7404270119439267 1395.2414751541987 854500.353762115 0.44495280841051904 1.1775788530238458 9.105936766039815e-06 5.040675369869618 1.0582951182179934 (ac)MS(ph)VMQSGT(ph)QMIK ddPTM_A459_Selumetinib_30min_R2 1 MSVMQSGTQMIK 12 0 Q4KWH8-2 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 2 MS(1)VMQS(0.245)GT(0.755)QMIK 66.00399999999999 0.020381 31764000.0 3171.5 3365.9 34381.0 20173.0 63857.0 31284.0 8111.4 17106.0 65125.0 16894.0 True False 2995.240726520415 3624.0537069256798 32168.963891202424 17425.402599633973 55834.71277117687 35593.087032123054 8488.596172434176 17155.775627949242 78151.81974453626 16406.22632411657 0.18256731727012185 0.22089502091035093 1.9607777715412342 1.0621213102503193 3.4032635944502254 2.1694865308424083 0.5174008943151199 1.0456868806406054 4.763546363471523 1.0 14.001955815258741 -5.259570909497105 6.88285213229135 1.964957222595206 0.19193615423543353 0.2589903848256575 1.2095441257967625 0.17562734192493074 55.61751802163474 0.312842561671952 0.7457536814324907 5.5008409811385714e-06 5.259570909497105 -1.7730210683597725 (ac)MTTS(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 MTTSQK 6 0 O75531;E9PJJ8;Q9ULM3 O75531;Q9ULM3 BANF1;YEATS2 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed;YEATS domain-containing protein 2 1 MT(0.032)T(0.011)S(0.957)QK 91.626 0.008925200000000001 15460000.0 5382.6 8997.1 8986.6 10161.0 10284.0 10547.0 10777.0 10420.0 4575.2 8691.3 True False 5508.004107283608 7943.7153493616825 7766.269079860351 8386.5720955928 9353.81401578767 10440.906755909798 9964.082213387526 10143.627751069866 7763.780240613135 9806.913015431159 0.5616450455527416 0.8100118086968102 0.7919178101855437 0.855169417980617 0.9537979995406772 1.0646476357525607 1.01602636810473 1.0343344266548389 0.7916640260188749 1.0 13.259583366244653 -4.219273616213259 0.5904722016658835 0.9872938959807075 4.805312779517237e-09 0.7069920070380011 0.0799336996625198 3.792889700757513 0.6180387162512996 0.04044957435216011 2.9531955334072695 6.03568246712173e-05 4.219273616213259 -0.9872938911753947 (ac)MVIMS(ph)EFS(ph)ADPAGQGQGQQK ddPTM_A459_Selumetinib_30min_R2 1 MVIMSEFSADPAGQGQGQQK 20 0 P57059;A0A0B4J2F2;A0A2R8Y6E4 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 2 MVIMS(1)EFS(1)ADPAGQGQGQQK 42.083 0.032493 0.0 10613.0 9867.8 12867.0 11329.0 12844.0 10078.0 10150.0 12574.0 10661.0 8901.3 True False 10023.171947205166 10624.628530022053 12039.151228530343 9785.970656384929 11230.421893183138 11466.153021024686 10621.99511184345 12610.588258262249 12793.497893228427 8644.296340645124 1.1595127645123209 1.2290911962452618 1.3927277309921402 1.1320725563712688 1.2991713206751323 1.3264414556348918 1.2287865539615141 1.4588334042839075 1.4799929790784623 1.0 13.077532815657616 -6.504412091520321 23.56131489585118 1.3219664677143907 1.2370797172619108 0.04337121478329742 0.14050022115712607 1021.799641281545 1303700.4450263786 0.04314244764638561 0.04797836978057819 3.130314035448268e-07 6.504412091520321 -0.08488675045247995 (ac)MVS(ph)RS(ph)GLS(ph)AGPTK ddPTM_A459_Selumetinib_30min_R2 1 MVSRSGLSAGPTK 13 1 E9PQ29 E9PQ29 LBHD1 3 MVS(1)RS(1)GLS(0.999)AGPT(0.002)K 52.49 0.043489 5375800.0 19397.0 25345.0 22052.0 13496.0 16163.0 28487.0 17252.0 14387.0 14413.0 22634.0 True False 18318.99239234323 27288.880002980284 20633.198328402206 11657.821518101433 14132.459440946668 32410.82567076107 18054.252184189474 14428.863788103927 17296.002732867582 21980.497609805512 0.8334202763531211 1.241504195555914 0.9387047870653176 0.5303711374077752 0.6429544813690737 1.4745264755199439 0.8213759535696527 0.656439360211172 0.7868794892592343 1.0 14.423936426940893 -5.520949813797285 24.978371452807263 0.8385389671621211 1.0506228319154836 0.08018244092807902 0.26143960315212006 171.49417490987435 2220732.493066088 0.07401168748635074 0.130784592665503 3.0133542212611187e-06 5.520949813797285 0.2120838647533625 (ac)NKMALAS(ph)FMK ddPTM_A459_Selumetinib_30min_R1 1 NKMALASFMK 10 1 E5RFN6;Q8WWZ4;E5RFP5;Q8WWZ4-3;Q8WWZ4-5;Q8WWZ4-4 E5RFN6 ABCA10 ATP-binding cassette sub-family A member 10 1 NKMALAS(1)FMK 49.466 0.020305 11576000.0 697.02 763.76 875.23 826.03 943.43 795.33 796.68 572.39 453.62 668.75 True False 713.2592098351762 674.3386241376088 756.3785732942582 681.7793670034955 858.0969230760943 787.3297023018615 736.5857861892524 557.2083578152476 769.7600089060438 754.5905766766291 0.945226765190357 0.8936483504836937 1.0023694923749298 0.9035089862984919 1.1371688828335602 1.0433866080986887 0.9761396563330098 0.7384247498415722 1.0201028646504227 1.0 9.55955027366674 (ac)PEGAQGLSLS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 PEGAQGLSLSK 11 0 Q9H7P9;Q9H7P9-3;E7ESZ3;Q9H7P9-2;C9J7S4;C9JVL3;M0R391 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 PEGAQGLSLS(1)K 85.676 0.013621 385030.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)QMMNLLTGGQK ddPTM_A459_Selumetinib_30min_R1 1 QMMNLLTGGQK 11 0 H7C422 H7C422 RPL3 0 40.715 0.047623 0.0 221.8 322.03 317.76 308.21 394.04 234.64 314.11 353.88 184.53 455.22 False True 226.96750845232862 284.32657789231445 274.6099373307396 254.38690931824198 358.3991515734122 232.2797346360742 290.41642980858836 344.49395283575825 313.1339324620438 513.6519212182952 0.4418702609230005 0.5535394031388806 0.5346226228053649 0.4952515483926924 0.6977471255696859 0.4522123349313015 0.5653953928951923 0.6706758771945738 0.6096228195143186 1.0 9.004647230821694 -14.5228787452784 0.18857168439733152 2.9150268366429377 0.4772245947100015 0.8018287761466326 0.0689713118852616 56.59556485846618 0.5508360697651709 40.52389598299481 0.18622393830969716 3.0000000000133884e-15 14.5228787452784 -2.4378022419329364 (ac)RWAPRTRPR ddPTM_A459_Selumetinib_30min_R2 1 RWAPRTRPR 9 3 M0R1M7 M0R1M7 MAP1S 0 44.753 0.03013 0.0 1239.8 1273.5 2540.8 2061.4 2102.3 2433.1 2222.1 2186.5 1171.6 2402.0 False True 1170.8968793126312 1371.1733550520973 2377.327694213873 1780.6337638866532 1838.190279199542 2768.2374395172806 2325.4320530076184 2192.8623530054388 1405.9527372391362 2332.648018854505 0.5019603771543828 0.5878183694964147 1.0191540579625507 0.7633529574517934 0.7880272824453914 1.1867360258135646 0.9969065346385049 0.9400742569306658 0.6027281981143294 1.0 11.187752915274768 -5.1617231956355845 5.057588575257058 0.912597655274696 0.5252186049833044 0.47781397637152756 0.15418834328038544 0.19098076300188443 7.5335364238215865 0.04072366457571515 0.1150844252595266 6.890913595375411e-06 5.1617231956355845 -0.38737905029139164 (ac)S(ph)AADEVDGLGVARPHYGSVLDNER ddPTM_A459_Selumetinib_30min_R1 2 SAADEVDGLGVARPHYGSVLDNER 24 1 P46940;A0A0J9YXZ5;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 S(1)AADEVDGLGVARPHYGSVLDNER;S(1)AADEVDGLGVARPHYGSVLDNER 102.67 2.0283e-07 18758100.0 137.55 119.9 117.72 259.16999999999996 53.358 0.0 159.03 199.8 0.0 0.0 True False 140.75464737429127 105.86205226000226 101.73427058967359 213.91082472343143 48.53177832112003 0.0 147.0342390642125 194.5006549581342 0.0 0.0 0.0 (ac)S(ph)AADEVDGLGVARPHYGSVLDNER ddPTM_A459_Selumetinib_30min_R2 2 SAADEVDGLGVARPHYGSVLDNER 24 1 P46940;A0A0J9YXZ5;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 S(1)AADEVDGLGVARPHYGSVLDNER;S(1)AADEVDGLGVARPHYGSVLDNER 77.668 4.9645e-06 9087900.0 24580.5 27295.8 27233.9 22726.6 25332.5 18316.6 14559.5 12631.599999999999 10667.1 29790.9 True False 23214.414213537802 29389.300090169658 25481.70052402833 19631.197874428275 22150.004874576596 20839.54538846008 15236.545599101932 12668.355864726042 12800.818063676665 28930.759310946145 0.8024128908623036 1.015849593655498 0.8807822929966155 0.6785579895582167 0.7656212765281966 0.7203248682303094 0.5266555722005224 0.4378853568469212 0.44246395077620343 1.0 14.820316568000537 -6.288922264383463 0.9391148299608506 0.5706576586581584 0.9176475566562661 0.2985345842546916 0.16663961787695147 0.6044648998553463 1.1379225739176941 0.08014616883463409 0.12399517422444183 5.14135669966942e-07 6.288922264383463 0.34698989799810764 (ac)S(ph)AIQNLHSFDPFADASK ddPTM_A459_Selumetinib_30min_R2 2 SAIQNLHSFDPFADASK 17 0 K7EM18;P41567 K7EM18 EIF1 Eukaryotic translation initiation factor 1 1 S(1)AIQNLHSFDPFADASK;S(0.999)AIQNLHS(0.001)FDPFADASK 79.633 0.0022894 4867500.0 20294.9 17164.1 18763.9 18471.2 23863.0 20339.2 19654.6 21528.0 15527.900000000001 17670.6 True False 19166.990704921718 18480.53127871982 17556.651102589618 15955.390695402717 20865.11660207328 23140.740179125332 20568.577844851054 21590.642915847737 18633.91388577635 17160.403864267442 1.1169312130720028 1.0769286914745193 1.0230907874579378 0.9297794400180822 1.2158872697349532 1.3484962453191764 1.1986068630750786 1.2581663629027542 1.0858668614773777 1.0 14.066795886123476 -6.285733521882947 24.318092270378006 1.206317038852454 1.0385864184188587 0.3318393506634878 0.09990815808367383 562.7076017161593 563260.3972497411 0.030745619940610945 0.03488089073628468 5.179245270279065e-07 6.285733521882947 -0.16773062043359532 (ac)S(ph)APAGSSHPAASAR ddPTM_A459_Selumetinib_30min_R2 1 SAPAGSSHPAASAR 14 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 1 S(1)APAGSSHPAASAR 87.713 0.0018653 934500.0 735.83 0.0 676.73 583.41 0.0 0.0 2052.1 2161.6 980.12 887.61 True False 694.9355143608759 0.0 633.1899285679133 503.94855156161475 0.0 0.0 2147.5267161590064 2167.8898981278553 1176.1713868409204 861.9823930122595 0.8062061591912263 0.0 0.7345740860845028 0.5846390316634313 0.0 0.0 2.491381185472153 2.5150048489412966 1.3644958370097384 1.0 9.751514590674569 -7.257721314688663 24.999927160190285 1.968970894454132 0.3497941043169508 0.6643747207222983 0.515164883444624 178.99597994700892 1203557.558290264 0.19947988176152956 0.14842693997946577 5.524318192105531e-08 7.257721314688663 -1.6191767901371812 (ac)S(ph)CGRPPPDVDGMITLK ddPTM_A459_Selumetinib_30min_R1 1 SCGRPPPDVDGMITLK 16 1 Q9BRL6-2;Q9BRL6 Q9BRL6-2 SRSF8 Serine/arginine-rich splicing factor 8 1 S(1)CGRPPPDVDGMITLK 60.19600000000001 0.043073 0.0 848.82 1096.6 1223.7 1356.5 1006.4 949.56 983.89 971.86 608.66 842.12 True False 868.5958544837948 968.2095622044909 1057.5282613029522 1119.6127396586592 915.3712976943511 940.008288531498 909.6743851656165 946.0831157538156 1032.8515652324684 950.2143049434363 0.9141052181228738 1.018938103928172 1.1129365826227 1.1782739260332507 0.9633314221141311 0.9892592477730107 0.9573360245505533 0.9956523605589513 1.0869669714075196 1.0 9.892109115651676 (ac)S(ph)CINLPTVLPGSPSKTR ddPTM_A459_Selumetinib_30min_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ERV3;P04183;K7ENW5;K7ES52;K7ERJ1 K7ERV3 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 S(0.286)CINLPT(0.249)VLPGS(0.154)PS(0.236)KT(0.074)R 129.89 1.6332e-07 33976000.0 696.34 336.89 3632.7 3072.5 1532.3 1015.4 653.72 850.89 821.09 561.64 True False 712.563367158226 297.44676218408796 3139.3992929927563 2535.945552968101 1393.7037355495377 1005.1859979094347 604.4093740870082 828.3216331197535 1393.329759959136 633.731964836878 1.1243923404457579 0.4693573603481568 4.953828222631684 4.001605873897888 2.1992006287836148 1.5861374424567154 0.953730295492642 1.3070535795570337 2.198610512439242 1.0 9.307728975305881 -6.682136528028577 3.7108544403985633 1.3895368794281444 2.688490025047773 0.17989223936134913 1.23713108240264 0.4401824963574914 11.870214497209119 0.4754883069927143 0.46485004493205334 2.079043001010541e-07 6.682136528028577 1.2989531456196286 (ac)S(ph)DAAVDTSSEITTK ddPTM_A459_Selumetinib_30min_R1 4 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 S(0.999)DAAVDT(0.001)SSEITTK;S(1)DAAVDTSSEITTK;S(1)DAAVDTSSEITTK;S(0.988)DAAVDT(0.006)S(0.006)S(0.001)EITTK 133.42 5.9382e-05 195499000.0 11296.8 13098.7 13604.4 14045.699999999999 12730.1 10557.099999999999 11813.400000000001 11294.300000000001 6576.219999999999 9215.4 True False 11559.993460253672 11565.098114579581 11756.997203620076 11592.882165443149 11578.664702681695 10450.905159079854 10922.305726977092 10994.73847494322 11159.365031894764 10398.28635559747 1.1117210148796148 1.1122119279157963 1.1306668042750334 1.1148839115401565 1.113516622520096 1.0050603341438138 1.0503947817418529 1.057360616831318 1.0731927021693914 1.0 13.344058170417188 -6.723051050929817 13.466228225485525 1.0416169883038688 1.1170612971023026 0.7712686068412044 0.02155162621606018 0.7277672791943605 254.57930028773745 0.007097989938462699 0.007089595660362845 1.8921211884103227e-07 6.723051050929817 0.07544430879843378 (ac)S(ph)DAAVDTSSEITTK ddPTM_A459_Selumetinib_30min_R2 5 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 S(1)DAAVDTSSEITTK;S(1)DAAVDTSSEITTK;S(0.985)DAAVDT(0.007)S(0.007)S(0.001)EITTK;S(1)DAAVDTSSEITTK;S(1)DAAVDTSSEITTK 143.24 1.8736e-08 229414000.0 862691.0 821869.0 944183.0 1027951.0 967276.0 648185.0 697176.0 725055.5 658136.0 785765.0 True False 814746.0878456952 884903.7095746486 883435.2937287206 887942.3004856183 845758.1413228438 737466.6001124112 729596.0654280359 727165.2914656006 789781.5898562782 763077.9227873483 1.0677102082440217 1.159650519493866 1.1577261867329807 1.1636325386563002 1.108350950887799 0.9664368186916157 0.9561226234445221 0.9529371375461013 1.0349946791428424 1.0 19.541470861875098 -6.690896795381295 4.437395148461752 0.9772108517407765 1.1395000678902492 0.8270177075338888 0.03423248318702349 0.08107712209682547 3.0667411660312554 0.01176541242566782 0.01153878826198866 2.0375262126444965e-07 6.690896795381295 0.16228921614947267 (ac)S(ph)DEFSLADALPEHSPAK ddPTM_A459_Selumetinib_30min_R1 1 SDEFSLADALPEHSPAK 17 0 Q8NDC0 Q8NDC0 MAPK1IP1L MAPK-interacting and spindle-stabilizing protein-like 1 S(0.99)DEFS(0.01)LADALPEHSPAK 122.7 3.2591e-16 198740000.0 7886.6 9140.2 9406.1 9930.5 7945.2 7416.0 7099.0 6934.3 5145.7 6897.1 True False 8070.342435347766 8070.061134836299 8128.8032840089145 8196.324593571922 7226.558062838993 7341.401773189252 6563.516714562308 6750.3798382191735 8731.877072941736 7782.4099684431785 1.036997853887436 1.0369617082060074 1.0445097748602712 1.0531859188615251 0.9285758643070585 0.9433326955220598 0.8433784317681349 0.8673893903805152 1.122001681786046 1.0 12.926001266497003 -6.261690320736935 24.990496494039586 0.9384067330935897 1.042602663898524 0.2727377366480499 0.07202393053593846 28.156345341882663 2803986.9558190126 0.022008702600757216 0.0265474847844833 5.474061587586175e-07 6.261690320736935 0.10419593080493428 (ac)S(ph)DEFSLADALPEHSPAK ddPTM_A459_Selumetinib_30min_R2 9 SDEFSLADALPEHSPAK 17 0 Q8NDC0 Q8NDC0 MAPK1IP1L MAPK-interacting and spindle-stabilizing protein-like 1 S(0.973)DEFS(0.005)LADALPEHS(0.022)PAK;S(0.925)DEFS(0.006)LADALPEHS(0.069)PAK;S(0.85)DEFS(0.15)LADALPEHSPAK;S(0.897)DEFS(0.103)LADALPEHSPAK;S(0.927)DEFS(0.073)LADALPEHSPAK;S(1)DEFSLADALPEHSPAK;S(0.994)DEFS(0.006)LADALPEHSPAK;S(0.96)DEFS(0.016)LADALPEHS(0.024)PAK;S(0.718)DEFS(0.282)LADALPEHSPAK 158.3 2.7640999999999985e-93 108143500.0 556145.5 534946.1000000001 470854.50000000006 511258.3 525244.3999999999 457441.9 484545.5 470183.9 365799.39999999997 517310.69999999995 True False 525237.1595368317 575974.7457471808 440560.2340976166 441624.0375702389 459258.50272748654 520450.3694808758 507077.82585869374 471552.0573058654 438969.50128920574 502374.5959563857 1.0455089962041608 1.1465045214929315 0.8769556375734102 0.8790731878659308 0.9141754109862626 1.0359806679517276 1.009361997879997 0.9386463031797169 0.873789209929149 1.0 18.93840398640841 -5.258279161762155 24.99959795461629 0.9414708856739892 1.0960067643859739 0.5202039041324746 0.0595453927747083 222.75843395314982 1762158.590453347 0.016461956235098343 0.039910663728324504 5.517226814044923e-06 5.258279161762155 0.1545358787119847 (ac)S(ph)DEREVAEAATGEDASSPPPK ddPTM_A459_Selumetinib_30min_R2 2 SDEREVAEAATGEDASSPPPK 21 1 K7ERT7;Q99536-3;Q99536 K7ERT7 VAT1 Synaptic vesicle membrane protein VAT-1 homolog 1 S(0.752)DEREVAEAAT(0.238)GEDAS(0.008)S(0.001)PPPK;S(0.809)DEREVAEAAT(0.189)GEDAS(0.001)S(0.002)PPPK 60.918 4.2771e-06 0.0 28128.0 23037.0 26673.0 26127.0 25988.0 21389.0 24025.0 24488.0 21163.0 21328.3 True False 26564.75836530547 24803.86382436998 24956.888219366592 22568.457528411094 22723.15510433223 24335.140599989758 25142.210104634356 24559.256025793373 25396.191343625676 20712.49656142152 1.282547388072194 1.1975313430139038 1.2049193657248711 1.0896058551650616 1.0970746591048661 1.1749013706689355 1.2138667123046618 1.1857216706332114 1.2261289346899815 1.0 14.338213837487642 -11.903186225543106 1.9469752925922081 2.7460937060601177e-05 1.18177980984367 0.510387649654507 0.054468292116292796 891763.9445840503 79665.84195598449 3931970.3172724596 0.01605126175440457 1.2497230338720309e-12 11.903186225543106 1.1817523489066095 (ac)S(ph)DFDEFER ddPTM_A459_Selumetinib_30min_R1 1 SDFDEFER 8 0 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 1 S(1)DFDEFER 143.11 0.00026956 20897000.0 280.65 222.83 56.813 106.77 243.8 112.63 216.59 214.44 0.0 55.46 True False 287.1885989501625 196.74096000914346 49.09810665147069 88.12462382112425 221.74833304638605 111.49704445985778 200.25244192239066 208.75235460071227 0.0 62.57883122614706 4.589229190176496 3.1438899729233034 0.7845801158228762 1.408217796568618 3.543503908614609 1.7817054469574596 3.2000029083112693 3.3358301922630047 0.0 1.0 5.967602808755623 -8.26461630665397 24.981822160513783 0.49999981957888145 2.640759301990664 0.39836018530133677 1.0891756011369915 312.6713778358335 2458632.075292134 0.9528651244138101 0.28631277794089727 5.437304979483394e-09 8.26461630665397 2.1407594824117826 (ac)S(ph)DKPDMAEIEK ddPTM_A459_Selumetinib_30min_R2 1 SDKPDMAEIEK 11 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 S(1)DKPDMAEIEK 66.962 0.047575 67795000.0 141020.0 107450.0 132700.0 113940.0 109340.0 90489.0 118550.0 123510.0 78719.0 84868.0 True False 133182.67294778774 115691.06949379505 124162.22647283539 98421.17544253675 95603.73168799776 102953.03837264352 124062.80990236845 123869.39365181867 94464.9995926317 82417.64032645478 1.6159486296896342 1.4037173235674403 1.5065006226947417 1.194176089641638 1.1599911294391965 1.2491626545585193 1.5052943691539566 1.5029475869628666 1.1461745230566849 1.0 16.33066553841107 -5.74867343507583 24.69292065624555 1.2787764538723492 1.4982218150383189 0.35595821936505934 0.15552043962072143 265.40355051663437 513359.628245157 0.04391411393933933 0.07541884951417208 1.783719519645461e-06 5.74867343507583 0.2194453611659697 (ac)S(ph)DKPDMAEIEKFDK ddPTM_A459_Selumetinib_30min_R1 2 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 S(1)DKPDMAEIEKFDK;S(1)DKPDMAEIEKFDK 69.92 0.0088504 151075000.0 15102.9 18276.1 24728.0 26714.0 18366.1 20583.7 18931.8 17955.699999999997 12538.099999999999 17413.7 True False 15454.768184872295 16136.325715671615 21370.07342118118 22048.901383886056 16704.88949779832 20376.646666504268 17503.759083920384 17479.456507666513 21276.239953407836 19648.91801880196 0.7865455069884102 0.82123227855248 1.08759542895605 1.1221432835531993 0.850168415472724 1.0370365761110076 0.8908255949345972 0.8895887545024362 1.0828199259139204 1.0 14.26216225122489 -5.139732985430743 6.378038544195556 0.9879115701367707 0.7960580385261963 0.42872774561021054 0.08822024874830267 0.22534606413835023 10.677352386928842 0.02308817718586608 0.06301582091735397 7.248814974702122e-06 5.139732985430743 -0.1918535316105744 (ac)S(ph)DKPDMAEIEKFDK ddPTM_A459_Selumetinib_30min_R2 2 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 S(1)DKPDMAEIEKFDK;S(1)DKPDMAEIEKFDK 61.657 0.032264 64168000.0 242670.0 268480.0 228880.0 224539.0 197485.0 131259.0 144504.0 151228.0 113088.0 192641.0 True False 229183.37288497874 289071.5527007355 214154.10998570136 193956.40084861964 172675.1687616997 149338.73579943238 151223.722329244 151668.04844285705 135708.75994272748 187078.9537885721 1.2250622971945369 1.5451847834654382 1.144725826442927 1.0367622702648855 0.9230069190832075 0.7982658272090192 0.8083417149111811 0.8107167875990219 0.7254090168587279 1.0 17.513287740269853 -5.819744745970763 1.331192283490166 0.8198565218589154 1.3942818755878958 0.796445894381997 0.10721636163733775 0.17539060286515754 0.6251360325945611 0.03522123038231177 0.08045359957247372 1.5144510966401525e-06 5.819744745970763 0.5744253537289804 (ac)S(ph)DNDDIEVESDADKR ddPTM_A459_Selumetinib_30min_R1 1 SDNDDIEVESDADKR 15 1 A0A494C130;Q6V3B1;G3V563;G3V2R5;P61244-2 A0A494C130 MAX 1 S(1)DNDDIEVESDADKR 144.55 7.547e-05 13349000.0 1114.9 1385.6 1371.9 1159.4 1228.6 1073.3 1176.0 1151.7 766.03 990.42 True False 1140.8750007822416 1223.373307852036 1185.6035153072814 956.9325546334318 1117.473346926947 1062.5035764784286 1087.2933731969677 1121.1531747511674 1299.8969613824263 1117.5500545077637 1.0208715002790203 1.0946921821688633 1.0608952239096732 0.856277131188475 0.999931360943962 0.9507436129529063 0.9729258826584525 1.0032241242608062 1.1631666574030808 1.0 10.126123735106832 -10.137591130492275 7.229144581531801 0.9999971085146254 1.0090256631062087 0.0 0.07878924007885865 0.0 0.0 0.0790921810891873 0.019182671575952878 7.284653004388331e-11 10.137591130492275 0.009028554591583249 (ac)S(ph)DNDDIEVESDADKR ddPTM_A459_Selumetinib_30min_R2 2 SDNDDIEVESDADKR 15 1 A0A494C130;Q6V3B1;G3V563;G3V2R5;P61244-2 A0A494C130 MAX 1 S(1)DNDDIEVESDADKR;S(1)DNDDIEVESDADKR 105.36 0.00012148 92580000.0 99467.0 89812.0 92877.0 98776.0 100984.0 63762.0 79910.0 71099.0 64534.0 93829.0 True False 93939.02233794924 96700.29160890367 86901.39493683176 85322.53840189578 88297.4871115856 72544.63672619323 83625.97333866112 71305.88631892687 77442.60323061663 91119.9129729805 1.0309384554153895 1.0612421418529878 0.9537036647807198 0.9363764255042277 0.9690251475302458 0.7961447104070947 0.9177573881513524 0.7825499826812936 0.8498976865087705 1.0 16.47547874870358 -5.803757252738065 0.8712269631333405 0.8616036821307862 1.0600799980154039 0.4719172296112265 0.06526618066490994 0.5994054874941441 0.8450066513752129 0.02763860809151062 0.08543141971285104 1.5712407980503577e-06 5.803757252738065 0.19847631588461767 (ac)S(ph)DNGELEDKPPAPPVR ddPTM_A459_Selumetinib_30min_R1 2 SDNGELEDKPPAPPVR 16 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 S(1)DNGELEDKPPAPPVR;S(1)DNGELEDKPPAPPVR 90.434 0.00019979 104305000.0 5147.8 5595.700000000001 6458.799999999999 6923.900000000001 5708.8 5436.7 5679.200000000001 5693.3 3468.9 4838.6 True False 5267.733724124873 4940.552842629646 5581.73043564886 5714.770842700028 5192.440047970504 5382.011734128644 5250.813371649849 5542.295189555281 5886.469941568214 5459.681441955197 0.9648426891072266 0.9049159543748685 1.0223545998042618 1.0467223964359136 0.951051833916341 0.9857739487821219 0.9617435426359693 1.0151316058415485 1.0781709526737842 1.0 12.41460106080375 -1.5228787525512655 0.347024481958184 1.0136393271968924 0.14325483772968153 0.20153535071881645 0.04274312872771454 104.62613211303548 1.4759895359866217 0.03865257029643326 59.41242570047129 0.029999999497742097 1.5228787525512655 -0.8703844894672109 (ac)S(ph)DNGELEDKPPAPPVR ddPTM_A459_Selumetinib_30min_R2 2 SDNGELEDKPPAPPVR 16 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 S(1)DNGELEDKPPAPPVR;S(1)DNGELEDKPPAPPVR 72.152 0.0014387 55633100.0 68006.0 63851.0 71424.0 65901.0 63984.0 49082.0 54764.0 48773.0 42211.0 59764.0 True False 64226.49876958764 68748.16638667563 66828.65760057131 56925.170114434 55945.75789578242 55842.5999779652 57310.63451280733 48914.92135519522 50654.379473882844 58038.45803447983 1.1066196612499868 1.184527789243355 1.1514547399048636 0.9808180996231077 0.9639428715102293 0.9621654652642545 0.9874596337270003 0.8428018767510252 0.8727726612548836 1.0 15.82472156994721 -5.836537864727265 3.2055164302135575 0.935882322847274 1.1544627392552687 0.7830968388827959 0.049339839875088054 0.11338183854033719 2.3354479851842713 0.01550257299134498 0.02535328519502725 1.4570086673325415e-06 5.836537864727265 0.21858041640799464 (ac)S(ph)DQDHSMDEMTAVVK ddPTM_A459_Selumetinib_30min_R1 2 SDQDHSMDEMTAVVK 15 0 P08047;H3BUU5;P08047-3 P08047 SP1 Transcription factor Sp1 1 S(0.732)DQDHS(0.268)MDEMTAVVK;S(0.978)DQDHS(0.021)MDEMTAVVK 91.937 5.8514e-14 30872000.0 5473.5 6165.6 6170.700000000001 6875.0 6308.7 5127.2 5933.6 5296.0 2999.2 4352.9 True False 5601.021900422999 5443.7286856903265 5332.752833228837 5674.4103097333455 5738.079198891445 5075.625023125124 5486.023774831237 5155.532876167561 5089.423347098904 4911.637115836559 1.1403574344618541 1.1083328343085745 1.0857383612552476 1.155299175388463 1.1682620404488342 1.0333876268586333 1.1169440342289716 1.049656714162496 1.0361969394459354 1.0 12.261988259351767 -7.919793568916143 0.7472267837813911 1.0008649822460505 1.1252029803708643 0.5929386280684594 0.03484568093481184 0.46531112971619537 0.5143685989401501 0.033201922183708245 0.01475614009959755 1.2028360369615293e-08 7.919793568916143 0.12433799812481383 (ac)S(ph)DQDHSMDEMTAVVK ddPTM_A459_Selumetinib_30min_R2 6 SDQDHSMDEMTAVVK 15 0 P08047;H3BUU5;P08047-3 P08047 SP1 Transcription factor Sp1 1 S(0.993)DQDHS(0.007)MDEMTAVVK;S(0.865)DQDHS(0.135)MDEMTAVVK;S(0.978)DQDHS(0.022)MDEMTAVVK;S(0.991)DQDHS(0.007)MDEMT(0.002)AVVK;S(0.817)DQDHS(0.183)MDEMT(0.001)AVVK;S(0.967)DQDHS(0.026)MDEMT(0.007)AVVK 90.05 1.7346e-05 42450000.0 120654.6 116786.8 140987.7 136570.69999999998 142527.5 103610.29999999999 108420.7 118573.8 92422.00000000001 112897.4 True False 113949.10035063232 125743.97203125127 131916.70487780104 117969.5350624019 124621.92123798348 117881.67834434143 113462.47738154144 118918.8301270508 110908.9824864421 109637.75871932722 1.0393235111850667 1.1469038905944435 1.2032050492340685 1.0759936762699067 1.1366697266861843 1.0751923399503145 1.0348850497026805 1.0846521446273187 1.0115947624428296 1.0 16.742385215579226 -7.447646668296765 0.7187416315162982 1.008864800449643 1.1287246681528953 0.46028247190669136 0.045102055793091046 0.6424738807534716 0.6390169282999162 0.040300736662946895 0.022961011604557085 3.567412516256978e-08 7.447646668296765 0.1198598677032523 (ac)S(ph)DQEAKPSTEDLGDK ddPTM_A459_Selumetinib_30min_R1 2 SDQEAKPSTEDLGDK 15 1 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 S(0.971)DQEAKPS(0.002)T(0.027)EDLGDK;S(0.962)DQEAKPS(0.013)T(0.024)EDLGDK 79.283 0.0011255999999999998 73266000.0 5422.8 7681.1 4445.1 5557.6 4670.0 5537.700000000001 5915.4 5407.700000000001 3204.2 5126.200000000001 True False 5549.14068906802 6781.7932411534875 3841.4798351865306 4587.06948907259 4247.599324555467 5481.995765829306 5469.196615484139 5264.2702293148295 5437.293374491301 5784.197703416425 0.9593622095230997 1.1724691286308964 0.6641335639197755 0.7930346997584897 0.734345460226339 0.9477538713089589 0.94554109245847 0.9101124303212352 0.9400255062650736 1.0 12.497901148995359 -8.063894995856188 0.9497880551948636 0.9861975207660053 0.8762089429753632 0.0711466862110397 0.13210759761317403 1.736899834729055 3.018649390062643 0.13298532619499603 0.04933539220068644 8.631872247887775e-09 8.063894995856188 -0.10998857779064208 (ac)S(ph)DQEAKPSTEDLGDKK ddPTM_A459_Selumetinib_30min_R1 5 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 S(0.989)DQEAKPS(0.006)T(0.006)EDLGDKK;S(1)DQEAKPSTEDLGDKK;S(1)DQEAKPSTEDLGDKK;S(0.995)DQEAKPS(0.003)T(0.002)EDLGDKK;S(0.996)DQEAKPS(0.001)T(0.003)EDLGDKK 87.21600000000002 0.0016657 4674506600.0 21801.7 30283.4 24178.9 26375.0 19524.5 22145.1 23186.2 20797.8 12697.52 20743.3 True False 22309.63719127652 26737.805449629283 20895.538185190795 21769.10137006793 17758.512422330456 21922.34040014203 21437.246266683273 20246.17478322464 21546.76404983172 23405.90461185244 0.9531627835473284 1.1423530042111516 0.8927464471768194 0.930068789524347 0.7587193367154791 0.936615813987418 0.9158905251552524 0.8650028750852999 0.9205695916115425 1.0 14.514584904215347 -5.286244797144228 24.49211811590412 0.8951834644256038 1.0477578852333882 0.3888578296785431 0.07240794737213888 462.01789996945155 456181.7111435037 0.01793029986223392 0.03735285276430975 5.173151566574671e-06 5.286244797144228 0.15257442080778438 (ac)S(ph)DQEAKPSTEDLGDKK ddPTM_A459_Selumetinib_30min_R2 4 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 S(0.996)DQEAKPS(0.002)T(0.002)EDLGDKK;S(1)DQEAKPSTEDLGDKK;S(0.998)DQEAKPS(0.001)T(0.001)EDLGDKK;S(0.999)DQEAKPSTEDLGDKK 84.18799999999997 0.0048146000000000005 7546560000.0 569420.0 720873.0 517648.0 534564.0 459238.0 357545.0 445266.0 421865.0 259983.4 449398.0 True False 537773.915968865 776161.6411279697 484343.09125252685 461755.4610256656 401544.41680018924 406793.57827964553 465971.751277841 423092.5573064901 311987.3445431348 436422.71206377045 1.2322317356624763 1.7784629893747517 1.1098026703563362 1.0580463579498436 0.920081392880202 0.9321090929387849 1.0677073818508163 0.9694558638017616 0.7148742169439315 1.0 18.7353666579708 -5.454184928081123 4.776595242110894 0.9603126388986071 1.504169802158086 0.6671908830515574 0.15392417986814644 0.1150672152121683 5.00389033592801 0.03926412784633273 0.08311376581458021 3.514107735153031e-06 5.454184928081123 0.543857163259479 (ac)S(ph)DQEAKPSTEDLGDKKEGEYIK ddPTM_A459_Selumetinib_30min_R1 3 SDQEAKPSTEDLGDKKEGEYIK 22 3 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 S(0.976)DQEAKPS(0.02)T(0.004)EDLGDKKEGEYIK;S(0.954)DQEAKPS(0.035)T(0.012)EDLGDKKEGEYIK;S(0.983)DQEAKPS(0.01)T(0.007)EDLGDKKEGEYIK 111.66 0.0002386 134200000.0 2989.67 2239.9900000000002 12678.7 11965.099999999999 4452.1900000000005 5204.620000000001 3276.83 3021.49 2895.04 2222.5899999999997 True False 3059.323494114849 1977.7309294569018 10957.002179113957 9875.619897744062 4049.4902005979857 5152.266248216863 3029.656074909032 2941.3502700172803 4912.671434644313 2507.881076359938 1.219883798698821 0.7886063450534415 4.36902781491437 3.937834210256103 1.6147058322540615 2.054430051242747 1.2080541232467148 1.1728428025329258 1.9588932987902306 1.0 11.292253221871563 -6.483101465001873 24.82354414617448 1.5129267450626367 2.603514698234873 0.2014648979645185 1.052120818582731 894.296792028299 558098.0245628783 0.3595285714759154 0.40760031341067965 3.2877480965156413e-07 6.483101465001873 1.0905879531722364 (ac)S(ph)DSGEQNYGER ddPTM_A459_Selumetinib_30min_R1 1 SDSGEQNYGER 11 0 P62995;P62995-2 P62995 TRA2B Transformer-2 protein homolog beta 1 S(0.997)DS(0.003)GEQNYGER 94.309 0.001629 595070.0 0.0 173.37 202.24 0.0 169.54 124.69 0.0 158.06 0.0 0.0 True False 0.0 153.07175980247365 174.77691882480121 0.0 154.20513693471807 123.43573180946169 0.0 153.86773534876227 0.0 0.0 0.0 (ac)S(ph)DSGEQNYGER ddPTM_A459_Selumetinib_30min_R2 2 SDSGEQNYGER 11 0 P62995;P62995-2 P62995 TRA2B Transformer-2 protein homolog beta 1 S(0.998)DS(0.002)GEQNYGER;S(0.988)DS(0.012)GEQNYGER 116.05 1.7567e-05 19656700.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)S(ph)DTSESGAGLTR ddPTM_A459_Selumetinib_30min_R2 1 SDTSESGAGLTR 12 0 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 S(1)DTSESGAGLTR 128.03 0.000443 1134400.0 857.02 1220.4 457.9 816.67 577.54 764.49 1217.7 1065.4 1062.2 812.14 True False 809.390259322884 1314.0007557955087 428.4392125238241 705.4381371656704 504.9842619268909 869.7915581507406 1274.3254628267741 1068.5001376135356 1274.6696803477375 788.6914080068676 1.0262445502840272 1.6660518200853367 0.5432279446362289 0.8944412605538714 0.6402811756286987 1.1028287481270074 1.6157466023969642 1.3547759323431496 1.6161830437192213 1.0 9.623317115837915 -7.066030258285065 6.18916848463867 1.4212685786642762 0.9582710390217796 0.29432616177100357 0.3226975941796021 0.29598309560101554 21.702847855348992 0.1263896966672283 0.098441837344846 8.589536741630004e-08 7.066030258285065 -0.4629975396424967 (ac)S(ph)DVEENNFEGR ddPTM_A459_Selumetinib_30min_R1 2 SDVEENNFEGR 11 0 Q13595;F8WEH2 Q13595 TRA2A Transformer-2 protein homolog alpha 1 S(1)DVEENNFEGR;S(1)DVEENNFEGR 74.165 0.019751 7316300.0 2509.34 2194.3 3293.7 3036.6 2313.2 2320.47 2130.5 2117.71 1570.02 1830.4299999999998 True False 2567.802739674329 1937.390335897606 2846.4336309990495 2506.314814041639 2103.9714684286296 2297.128178618185 1969.7946697246105 2061.54145150846 2664.2092702761497 2065.383520398059 1.243257106641114 0.9380293377784942 1.3781622652099306 1.2134864006073796 1.0186831877225078 1.1122041770602789 0.9537185952490675 0.9981397794396759 1.2899344087739597 1.0 11.012193984758069 -6.257299886712183 24.734685817781077 1.0591051487628194 1.1882140712393774 0.1872756395803219 0.13356393929892826 558.2207006017438 3335530.0694954316 0.03985326728326655 0.04953621890491883 5.529681447371991e-07 6.257299886712183 0.12910892247655803 (ac)S(ph)DVEENNFEGR ddPTM_A459_Selumetinib_30min_R2 2 SDVEENNFEGR 11 0 Q13595;F8WEH2 Q13595 TRA2A Transformer-2 protein homolog alpha 1 S(1)DVEENNFEGR;S(1)DVEENNFEGR 149.72 0.00046546 26759000.0 0.0 1842.5 1917.9 2329.1 1391.6 0.0 0.0 0.0 0.0 0.0 True False 0.0 1983.8138254287314 1794.5044020516325 2011.8725620783948 1216.774766938153 0.0 0.0 0.0 0.0 0.0 0.0 (ac)S(ph)DVEENNFEGRES(ph)R ddPTM_A459_Selumetinib_30min_R2 5 SDVEENNFEGRESR 14 1 Q13595 Q13595 TRA2A Transformer-2 protein homolog alpha 2 S(1)DVEENNFEGRES(1)R;S(1)DVEENNFEGRES(1)R;S(1)DVEENNFEGRES(1)R;S(1)DVEENNFEGRES(1)R;S(1)DVEENNFEGRES(1)R 121.03 0.00046158 64900600.0 4567.57 5158.39 4976.719999999999 4763.38 5500.969999999999 3866.0299999999997 4355.9 2826.73 2781.62 7197.99 True False 4313.722744831424 5554.02192616191 4656.523253443033 4114.599426711172 4809.8889693042365 4398.54054017385 4558.457981052103 2834.9553163096584 3338.021724956576 6990.16532607599 0.6171131215937895 0.7945480066749329 0.6661535223026014 0.588626911492657 0.6880937352599531 0.6292469970296141 0.6521244875349815 0.4055634143207158 0.47753115545128494 1.0 12.771110862192605 -7.554387934976087 24.97319027974346 0.5706971582651776 0.6654226710421762 0.0 0.15715531541720054 562.3347353049138 445682.5470906124 0.0699605226293397 0.04039211302707407 2.7900505060110742e-08 7.554387934976087 0.09472551277699859 (ac)S(ph)EASSEDLVPPLEAGAAPYREEEEAAK ddPTM_A459_Selumetinib_30min_R1 1 SEASSEDLVPPLEAGAAPYREEEEAAK 27 1 Q03169;H0YKI8;H0YL88;H0YKY9 Q03169 TNFAIP2 Tumor necrosis factor alpha-induced protein 2 1 S(0.458)EAS(0.458)S(0.083)EDLVPPLEAGAAPYREEEEAAK 86.85600000000002 4.9575999999999996e-14 2998600.0 610.75 677.63 853.7 768.35 821.35 660.79 717.12 803.94 331.24 463.02 True False 624.9792866873748 598.2927645783597 737.7722290384332 634.1720962157987 747.0590375211206 654.1430525493155 663.0270610433756 782.6168996348474 562.0900871875971 522.4531271967294 1.1962399192455007 1.145160653528011 1.4121309465540353 1.213835391547004 1.4299063373006013 1.2520607466916325 1.2690651592055897 1.4979657674441549 1.0758670164413475 1.0 9.029157798845363 -8.462361178408438 7.783817546669741 1.0001493917513746 1.2987923158699493 0.5005031657422283 0.10683704841557105 0.20095527865797255 22.57777711517846 0.10075579944280666 0.02604850815208805 3.4485682193238813e-09 8.462361178408438 0.2986429241185746 (ac)S(ph)EASSEDLVPPLEAGAAPYREEEEAAKK ddPTM_A459_Selumetinib_30min_R2 2 SEASSEDLVPPLEAGAAPYREEEEAAKK 28 2 Q03169;H0YKI8;H0YL88;H0YKY9 Q03169 TNFAIP2 Tumor necrosis factor alpha-induced protein 2 1 S(0.487)EAS(0.455)S(0.058)EDLVPPLEAGAAPYREEEEAAKK;S(0.705)EAS(0.148)S(0.148)EDLVPPLEAGAAPYREEEEAAKK 58.98 9.5421e-06 0.0 24495.0 23706.0 22796.0 23801.0 24296.0 16214.0 18041.300000000003 18855.6 15265.7 23064.0 True False 23133.665961254163 25524.173973195928 21329.33017840815 20559.262740984894 21243.719271004153 18447.33132396251 18880.256198157756 18910.46667428737 18319.266559296233 22398.08239253133 1.0328413636413853 1.1395696080530089 0.9522837627171351 0.9179028088511901 0.948461519995475 0.8236120843145838 0.842940742304502 0.8442895397417187 0.8178944178455569 1.0 14.451087601064039 -5.628863532971054 1.1638745395643488 0.8626009514692422 1.099126757120264 0.6049263441448612 0.06258780091968164 0.3508652128659898 0.878166493920545 0.021199006239146976 0.07064816000138306 2.3503712548069324e-06 5.628863532971054 0.23652580565102188 (ac)S(ph)EGESQTVLSSGSDPK ddPTM_A459_Selumetinib_30min_R1 4 SEGESQTVLSSGSDPK 16 0 F8W6G1;Q9UHY1;C9JDW7;C9JHZ6 F8W6G1 NRBP1 Nuclear receptor-binding protein 1 S(0.828)EGES(0.172)QTVLSSGSDPK;S(0.5)EGES(0.5)QTVLSSGSDPK;S(0.963)EGES(0.037)QTVLSSGSDPK;S(0.981)EGES(0.019)QTVLSSGSDPK 89.189 8.959299999999998e-07 33023900.0 14041.8 15626.2 15851.900000000001 16419.4 15818.300000000001 14019.1 14480.0 14164.000000000002 7775.199999999999 11361.5 True False 14368.946619413473 13796.677239576715 13699.299048253879 13552.060020310648 14387.537557947699 13878.080582324352 13387.761942085115 13788.324708843911 13193.946521860304 12819.85919538172 1.1208349795752675 1.0761956921139109 1.0685998059314858 1.0571145762032004 1.1222851467144606 1.0825454765777653 1.044298672711474 1.0755441614999233 1.0291802991575247 1.0 13.646092796011557 -8.367519610102404 0.7477934246213984 0.9992967660346124 1.0865225731232429 0.6106898359994324 0.022396563696449465 0.4728928309197403 0.5987653919608944 0.022179002122287475 0.008738480656351515 4.290228167355097e-09 8.367519610102404 0.08722580708863048 (ac)S(ph)EGESQTVLSSGSDPK ddPTM_A459_Selumetinib_30min_R2 3 SEGESQTVLSSGSDPK 16 0 F8W6G1;Q9UHY1;C9JDW7;C9JHZ6 F8W6G1 NRBP1 Nuclear receptor-binding protein 1 S(0.964)EGES(0.036)QTVLSSGSDPK;S(0.988)EGES(0.012)QTVLSSGSDPK;S(0.935)EGES(0.065)QTVLSSGSDPK 88.803 7.510800000000002e-07 40330000.0 188736.0 186087.0 209206.0 213829.0 220155.0 146700.0 174964.0 183644.0 140621.0 188420.0 True False 178246.8086900701 200359.27453598706 195745.91372627037 184705.12132440045 192497.16068932807 166906.59338999016 183100.1726845888 184178.3736360993 168749.12927902365 182979.82502604733 0.9741336711011529 1.094980140610943 1.0697677391395788 1.0094288881198106 1.0520130329227604 0.9121584489778087 1.0006577099881058 1.0065501680848223 0.9222280612357241 1.0 17.48132506316791 -6.73215866692724 24.954534221255923 0.9707494132741533 1.0430637676840098 0.4129227969520741 0.04264996347879359 204.17186255168656 174005.28380963416 0.013790967866650827 0.013788889498307734 1.8528545702556335e-07 6.73215866692724 0.07231435440985645 (ac)S(ph)EKSVEAAAELSAK ddPTM_A459_Selumetinib_30min_R1 4 SEKSVEAAAELSAK 14 1 P20962;F5H7R9;F5GXR3 P20962 PTMS Parathymosin 1 S(0.776)EKS(0.224)VEAAAELSAK;S(0.766)EKS(0.234)VEAAAELSAK;S(0.953)EKS(0.047)VEAAAELSAK;S(0.822)EKS(0.178)VEAAAELSAK 80.014 0.00024146 95017200.0 5919.4 6014.0 12372.7 12915.300000000001 8120.1 8219.7 6839.599999999999 6656.1 4394.049999999999 5252.03 True False 6057.310502852632 5309.878084167254 10692.555298376275 10659.885305207143 7385.6383887200955 8137.017280890463 6323.683465406448 6479.5586059401285 7456.3819212856615 5926.179209604423 1.0221274599721333 0.8960036300558809 1.8042915882542154 1.7987787625340306 1.2462732103596126 1.3730629792131472 1.0670759762306545 1.0933787819711656 1.2582106712536256 1.0 12.532886539192518 -7.254892779936872 22.531095655740273 1.1124479108462686 1.3712255023284836 0.1639733434632814 0.277485734782795 280.03124128426026 963773.4550747772 0.11958597339505733 0.09012582468628534 5.560415177014583e-08 7.254892779936872 0.258777591482215 (ac)S(ph)EKSVEAAAELSAK ddPTM_A459_Selumetinib_30min_R2 2 SEKSVEAAAELSAK 14 1 P20962;F5H7R9;F5GXR3 P20962 PTMS Parathymosin 1 S(0.5)EKS(0.5)VEAAAELSAK;S(0.5)EKS(0.5)VEAAAELSAK 62.408 0.0053805 23806000.0 70163.0 77995.0 74108.0 64584.0 65833.0 43994.0 49179.0 44310.0 32005.0 63936.0 True False 66263.62134474285 83976.96570654765 69339.97196268951 55787.54778638576 57562.469985512726 50053.7741622306 51465.92094633978 44438.934764084595 38406.89429441664 62090.001554322014 1.0672188707672905 1.3525038428784208 1.1167655053450845 0.89849486857522 0.9270811490502511 0.8061487020327899 0.8288922476723194 0.7157180488263533 0.6185681000638207 1.0 15.92207334736155 -5.913736535015256 1.212467194601641 0.7814312384094514 1.230832824819753 0.6538557681311536 0.11861892308752538 0.27715510837342905 0.8229067203531242 0.043225043277283694 0.09260698712064092 1.2197293239857262e-06 5.913736535015256 0.4494015864103017 (ac)S(ph)ESGHSQPGLYGIER ddPTM_A459_Selumetinib_30min_R1 2 SESGHSQPGLYGIER 15 0 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 S(0.972)ES(0.028)GHSQPGLYGIER;S(0.461)ES(0.188)GHS(0.351)QPGLYGIER 124.39 2.8807e-05 29305000.0 828.61 817.75 727.82 733.3 740.6700000000001 565.6500000000001 583.79 635.46 154.56 685.5 True False 847.9150008056085 722.0074498383389 628.9860416290882 605.2429207458127 673.676529275909 559.9600745691076 539.7542502879744 618.6055365350146 262.2770313842381 773.4906023354457 1.0962188787367926 0.9334404938577654 0.8131786472000482 0.7824825782218519 0.8709563209195275 0.7239390793868564 0.6978161708212907 0.7997583094962272 0.3390823761689278 1.0 9.595239953270095 -1.5229011517962596 0.4462293387502934 0.7034206122857228 9.519801259209201 0.3461369828102545 0.1575074445753533 92.13809712746279 1.1192477372363123 0.09480728595456571 738.3314923334649 0.029998452252640296 1.5229011517962596 8.816380646923479 (ac)S(ph)ESGHSQPGLYGIER ddPTM_A459_Selumetinib_30min_R2 2 SESGHSQPGLYGIER 15 0 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 S(0.99)ES(0.007)GHS(0.003)QPGLYGIER;S(0.905)ES(0.092)GHS(0.002)QPGLYGIER 120.86 1.4541e-06 49014000.0 1570.1 1800.8 1278.2 1939.9 2183.0 2171.2 1522.0 1209.2 0.0 2028.3 True False 1482.8401276082939 1938.9155695153659 1195.9620035989344 1675.6822734858451 1908.7520237323881 2470.2630918087693 1592.7760157857854 1212.7185718061644 0.0 1969.7377088437083 0.752810955971779 0.9843521605998822 0.6071681514900773 0.85071340512109 0.9690386771611736 1.2541076310403194 0.8086234063726129 0.6156751563222417 0.0 1.0 10.943787817214957 -7.821740250787646 3.6083673723423146 0.4519809761001622 0.9009716141927778 0.25360491784381467 0.27623515833138096 0.27248547362225833 7.071936649970087 0.16024595460498775 0.07298554904549047 1.507508429357582e-08 7.821740250787646 0.44899063809261563 (ac)S(ph)ETAPAAPAAAPPAEK ddPTM_A459_Selumetinib_30min_R1 2 SETAPAAPAAAPPAEK 16 0 P16403 P16403 HIST1H1C Histone H1.2 1 S(0.5)ET(0.5)APAAPAAAPPAEK;S(0.5)ET(0.5)APAAPAAAPPAEK 56.956 0.0002642 38759000.0 11854.3 21086.0 13209.0 16168.1 13438.3 12535.4 13909.3 9993.3 7214.0 11647.099999999999 True False 12130.482125547516 18617.241317384556 11415.29035184335 13344.644847825415 12222.80813772457 12409.30525723254 12860.110302558323 9728.245221186804 12241.63111028658 13142.118737361296 0.9230233243184882 1.4166088200419478 0.8686035014575845 1.0154104611677541 0.930048524289828 0.9442393197951054 0.9785416308862543 0.7402341597729365 0.9314807874536433 1.0 13.681910261410223 -5.297769342151373 24.98172889560436 0.9226481649035252 1.1698163919320121 0.35005793602202906 0.13278564371086646 499.3822687956305 343391.4881878465 0.03251762852310326 0.06769458853605871 5.037680936813596e-06 5.297769342151373 0.24716822702848695 (ac)S(ph)ETAPAAPAAAPPAEK ddPTM_A459_Selumetinib_30min_R2 1 SETAPAAPAAAPPAEK 16 0 P16403 P16403 HIST1H1C Histone H1.2 1 S(0.5)ET(0.5)APAAPAAAPPAEK 63.966 0.00066391 14861000.0 113730.0 119410.0 124540.0 104290.0 102040.0 74235.0 79856.0 74434.0 68163.0 115980.0 True False 107409.34189726209 128568.36303633385 116527.23198889942 90085.5220897151 89220.82295082584 84460.19741176502 83569.462231662 74650.5906167879 81797.50463334852 112631.35604777066 0.9536362312081749 1.1414970710447965 1.034589621201723 0.7998263117022836 0.7921490611636102 0.7498817414214801 0.7419733293117543 0.6627869292910415 0.7262409643603643 1.0 16.781248997388886 -5.779962777108101 3.875909843475268 0.7616148640331849 1.0585835265794974 0.6193598387906041 0.09339457060866635 0.12271176678061105 4.006176108666192 0.025535411944183177 0.042234592420858696 1.6597291548618764e-06 5.779962777108101 0.2969686625463125 (ac)S(ph)ETAPAAPAAAPPAEKAPVK ddPTM_A459_Selumetinib_30min_R1 2 SETAPAAPAAAPPAEKAPVK 20 1 P16403 P16403 HIST1H1C Histone H1.2 1 S(0.5)ET(0.5)APAAPAAAPPAEKAPVK;S(0.5)ET(0.5)APAAPAAAPPAEKAPVK 94.09 4.5244e-09 23424000.0 5474.5 4851.700000000001 17998.8 18619.3 10693.1 7435.299999999999 6073.0 4495.4 4827.3 3218.3999999999996 True False 5602.045198477336 4283.660708505862 15554.661820331445 15367.788782548074 9725.910993020145 7360.507632712251 5614.908720599652 4376.167388882863 8191.575527957639 3631.5129898707455 1.5426201734932323 1.179580169602623 4.2832455408303725 4.231786813213368 2.678198045869117 2.0268432615393808 1.5461623671073528 1.2050534862711924 2.255692200690489 1.0 11.826355025229136 -6.8988094720503055 2.8674924005976603 1.5354291514882494 2.8636110679935256 0.280103056173144 0.9696463110384335 0.3991996730497351 6.625161027124845 0.418567569864328 0.3595590053851146 1.2623812283774165e-07 6.8988094720503055 1.3281819165052762 (ac)S(ph)ETAPAAPAAPAPAEKTPVK ddPTM_A459_Selumetinib_30min_R1 2 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 S(0.473)ET(0.473)APAAPAAPAPAEKT(0.053)PVK;S(0.5)ET(0.5)APAAPAAPAPAEKTPVK 134.99 6.1288e-05 984680000.0 4830.6 7020.700000000001 5256.1 5956.6 4293.5 4333.1 3783.2 3419.2999999999997 2455.15 3841.8999999999996 True False 4943.143581288634 6198.713180165121 4542.350489690649 4916.391629230206 3905.1536830789923 4289.512948140013 3497.8301781282066 3328.60905654829 4166.210232938745 4335.045288275052 1.1402749573708717 1.4299073638124866 1.0478207694799158 1.1341038679636206 0.9008334223499849 0.9894966863995192 0.8068728111304276 0.7678372047348943 0.9610534506310803 1.0 12.081831350041963 -5.94169854327053 1.0843759666480932 0.8763751123311588 1.2812457218470708 0.6215989939664579 0.11076869859350914 0.31854413959801847 0.7547621627761201 0.041899341005646455 0.09251493166694673 1.1436719160594367e-06 5.94169854327053 0.4048706095159119 (ac)S(ph)ETAPAAPAAPAPAEKTPVK ddPTM_A459_Selumetinib_30min_R2 3 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 S(0.499)ET(0.499)APAAPAAPAPAEKT(0.003)PVK;S(0.5)ET(0.5)APAAPAAPAPAEKT(0.001)PVK;S(0.498)ET(0.498)APAAPAAPAPAEKT(0.004)PVK 115.57 3.4597e-13 156843900.0 334638.0 339951.0 285627.0 294015.0 232759.0 171069.0 236668.0 189492.7 127756.8 318346.0 True False 316040.1596220525 366024.14858524903 267250.0697871643 253969.6497958355 203517.73352813863 194632.20194023338 247673.53094874517 190044.0923847949 153311.72982324395 309154.52381775813 1.022272473063837 1.1839521028681912 0.8644546632761037 0.8214974397254711 0.6583042389769759 0.6295628462320871 0.8011318349484834 0.6147220168022609 0.4959064739858663 1.0 18.23796859095765 -5.6158505235263885 1.6810939309262765 0.6853412987012443 1.1094804913683292 0.5553165768441573 0.13609646544135456 0.2593481573945055 1.4494902429347036 0.04033290973593467 0.10385664978983701 2.421862465497353e-06 5.6158505235263885 0.4241391926670849 (ac)S(ph)ETAPAETATPAPVEK ddPTM_A459_Selumetinib_30min_R1 2 SETAPAETATPAPVEK 16 0 P16401 P16401 HIST1H1B Histone H1.5 1 S(0.947)ET(0.053)APAETATPAPVEK;S(0.976)ET(0.024)APAETATPAPVEK 136.6 0.0023479 15782700.0 7738.5 13033.3 8703.8 9844.2 8635.8 7472.5 8093.200000000001 5780.4 4368.8 7254.6 True False 7918.791993500204 11507.355176983212 7521.871766551147 8125.09526852029 7854.693414774328 7397.333434487152 7482.7234081272945 5627.085014614611 7413.534515472694 8185.798575788072 0.9673817307113297 1.4057706246302748 0.9188928480111047 0.9925843145655537 0.9595512694396016 0.9036788977885383 0.9141103752857624 0.6874204101794521 0.9056580670577971 1.0 12.998907452140998 -5.759684275487794 1.0706346224815142 0.8690861419825882 1.1811063530164625 0.33429283883984584 0.13782466145151398 0.5965306823302903 1.3083138978340443 0.050458355654616434 0.14545873565944095 1.7390646389647869e-06 5.759684275487794 0.31202021103387434 (ac)S(ph)ETAPAETATPAPVEKSPAK ddPTM_A459_Selumetinib_30min_R1 5 SETAPAETATPAPVEKSPAK 20 1 P16401 P16401 HIST1H1B Histone H1.5 1 S(0.863)ET(0.134)APAET(0.003)ATPAPVEKSPAK;S(0.894)ET(0.082)APAET(0.001)AT(0.001)PAPVEKS(0.023)PAK;S(0.851)ET(0.145)APAET(0.001)ATPAPVEKS(0.003)PAK;S(0.765)ET(0.188)APAET(0.047)ATPAPVEKSPAK;S(0.76)ET(0.047)APAET(0.008)AT(0.052)PAPVEKS(0.134)PAK 146.1 1.5929e-16 1933506600.0 19979.3 30618.000000000004 25845.499999999996 29255.799999999996 19194.5 19439.4 18446.5 15115.0 12283.169999999998 18883.910000000003 True False 20444.778817049628 27033.230326077985 22335.823059169277 24146.823729381344 17458.36086406421 19243.857285563 17055.065653637652 14714.101099560552 20843.642362758346 21307.843793360098 0.9594954334807252 1.26869854069899 1.0482441712910209 1.133236378281782 0.8193396306718066 0.9031348958715254 0.8004125531909668 0.690548571796163 0.9782145281754692 1.0 14.379096989281312 -6.260603360299416 24.999999366949986 0.8484523224756272 1.110426172652239 0.5193531226714279 0.11095098932855348 53.97434951756352 1614023.5416945063 0.032053151562439604 0.038993506271210225 5.487779331741826e-07 6.260603360299416 0.2619738501766119 (ac)S(ph)ETAPAETATPAPVEKSPAK ddPTM_A459_Selumetinib_30min_R2 3 SETAPAETATPAPVEKSPAK 20 1 P16401 P16401 HIST1H1B Histone H1.5 1 S(0.952)ET(0.027)APAETAT(0.012)PAPVEKS(0.01)PAK;S(0.967)ET(0.018)APAET(0.007)AT(0.002)PAPVEKS(0.006)PAK;S(0.85)ET(0.137)APAET(0.002)ATPAPVEKS(0.011)PAK 112.96 1.9669e-09 166928300.0 158463.4 248503.0 150572.0 139073.0 102938.2 85487.6 113050.3 80350.1 57383.4 144356.0 True False 149656.63860725058 267562.3810369145 140884.36145039767 120131.0174856937 90006.18303681586 97262.74092083245 118307.36295491984 80583.90548832495 68861.68342615935 140188.06719806883 1.0675419213520063 1.9085959767094949 1.0049668582087308 0.8569275537265454 0.6420388328034223 0.6938018539296353 0.8439189249093919 0.5748271382789636 0.4912093076286307 1.0 17.097004026874963 -5.532046394680893 3.353343208864578 0.7127037069236467 1.4926095735299203 0.6109774941442341 0.23771385768647274 0.13590624840751608 3.190340282903731 0.06213558675254826 0.12799737688698232 2.937335846365855e-06 5.532046394680893 0.7799058666062736 (ac)S(ph)ETAPLAPTIPAPAEK ddPTM_A459_Selumetinib_30min_R1 4 SETAPLAPTIPAPAEK 16 0 P16402 P16402 HIST1H1D Histone H1.3 1 S(0.5)ET(0.5)APLAPTIPAPAEK;S(0.5)ET(0.5)APLAPTIPAPAEK;S(0.5)ET(0.5)APLAPT(0.001)IPAPAEK;S(0.5)ET(0.5)APLAPTIPAPAEK 90.697 0.00028025 57974800.0 21818.5 32947.2 25601.5 30061.0 24131.2 21930.2 22063.4 18340.6 12581.300000000001 20037.300000000003 True False 22326.828598589407 29089.72650726227 22124.956918973232 24811.41066485733 21948.53722070939 21709.602099028445 20399.139974654743 17854.147709335117 21349.547198204666 22609.282634830077 0.9875071650523957 1.2866275758103414 0.9785784571903785 1.097399287964795 0.9707754808149996 0.9602074709608144 0.9022462279820165 0.789682184866424 0.9442823791903613 1.0 14.464627597397774 -6.400963947538667 1.0991229424305862 0.8937291951476957 1.114719934438892 0.4125969543257172 0.09414974535144613 0.42404005647593135 1.0784017042458938 0.04100347532876511 0.05330205780568958 3.972245232417546e-07 6.400963947538667 0.2209907392911964 (ac)S(ph)ETAPLAPTIPAPAEK ddPTM_A459_Selumetinib_30min_R2 1 SETAPLAPTIPAPAEK 16 0 P16402 P16402 HIST1H1D Histone H1.3 1 S(0.5)ET(0.5)APLAPTIPAPAEK 68.515 0.0017058 3577500.0 48047.0 47749.0 44096.0 39807.0 37980.0 30481.0 27616.0 24836.0 23289.0 45420.0 True False 45376.74008738026 51411.1947627661 41258.911368094676 34385.21792909482 33208.61285449201 34679.481071031296 28900.198720065873 24908.26864817885 27947.450749028896 44108.6065846676 1.0287502508218764 1.1655592580119483 0.9353936694621522 0.7795580180727657 0.7528828368392736 0.7862293496953513 0.6552054339914638 0.5647031401993349 0.6336053870888678 1.0 15.428772565163383 -5.661574928014699 1.768248339839834 0.7080357108425549 1.1053880636928257 0.6069260858575205 0.11594838090636096 0.22531726128803994 1.4145323535026109 0.03545350155180094 0.08328795724033379 2.179842280629833e-06 5.661574928014699 0.3973523528502708 (ac)S(ph)FEGGDGAGPAMLATGTAR ddPTM_A459_Selumetinib_30min_R1 2 SFEGGDGAGPAMLATGTAR 19 0 Q96B36-3 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 S(1)FEGGDGAGPAMLATGTAR;S(1)FEGGDGAGPAMLATGTAR 204.07 8.1969e-30 7183900.0 207.82 262.89 281.84 433.67 392.32 148.24 370.445 331.96000000000004 106.66 230.91 True False 212.66180165267323 232.1107165857547 243.56767603630306 357.9376754941177 356.83472526972156 146.74884019115083 342.5020354030193 323.1553424419532 180.9942298618196 260.54954775386994 0.8162048389105852 0.8908505832641851 0.9348228701068062 1.373779684439315 1.3695465156086477 0.5632281516365486 1.3145370558331055 1.2402836436593023 0.6946633813880082 1.0 8.025413940403656 -5.538145710353968 24.981177510461375 1.0947812938648511 0.868354856216092 0.11182490621543517 0.2603174639440763 477.14715884126946 780748.0953595241 0.07114164860942487 0.12327354138035025 2.8963716615924025e-06 5.538145710353968 -0.22642643764875914 (ac)S(ph)FLFSSR ddPTM_A459_Selumetinib_30min_R1 1 SFLFSSR 7 0 Q9H8S9-2;Q9H8S9 Q9H8S9-2 MOB1A MOB kinase activator 1A 1 S(1)FLFSSR 71.296 0.010271 5241200.0 240.51 180.56 142.31 250.33 193.36 173.0 289.73 110.46 0.0 165.71 True False 246.11341504900605 159.41995125993333 122.98508365287508 206.61456477607973 175.87062214048075 171.25977707143213 267.87543283703866 107.53024197535285 0.0 186.9804926520885 1.3162518269055223 0.8526020495440848 0.6577428581371394 1.105005992044978 0.9405827294921096 0.9159232315752444 1.432638394719978 0.575088023623045 0.0 1.0 7.546743953887076 -7.9793834351053645 22.76641187588983 0.4291813720612008 1.0050656139118839 0.35569298966891627 0.30913696304800536 76.03932053477256 83968.1525886381 0.16147989199453786 0.07754937324164031 1.0486162050206186e-08 7.9793834351053645 0.5758842418506831 (ac)S(ph)GDEMIFDPTMSK ddPTM_A459_Selumetinib_30min_R1 15 SGDEMIFDPTMSK 13 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 S(0.999)GDEMIFDPT(0.001)MSK;S(1)GDEMIFDPTMSK;S(0.999)GDEMIFDPTMSK;S(0.961)GDEMIFDPT(0.036)MS(0.002)K;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK 138.22 9.4619e-05 1355406400.0 61632.01999999999 71633.99999999999 70812.01 75937.42 66585.48 59564.88 64569.52 56758.05999999999 34071.86 51376.13 True False 63067.92615096519 63247.05797825692 61196.12798452832 62676.37511891653 60562.83509062122 58965.71138778381 59698.98912118121 55252.651872638045 57817.45790980442 57970.75673138457 1.0879265634429969 1.0910166012032723 1.0556379015041832 1.0811722781080138 1.0447135505104306 1.017163044136365 1.0298121412802086 0.9531124827067338 0.9973555835696525 1.0 15.82303769775615 -6.806995004327174 0.88655272486164 0.9833209035777204 1.0841906915274448 0.8118523395340035 0.018544297491406805 0.23045030074358175 0.3907422348674064 0.011587599071841505 0.010282212372749917 1.559570442402965e-07 6.806995004327174 0.10086978794972445 (ac)S(ph)GDEMIFDPTMSK ddPTM_A459_Selumetinib_30min_R2 14 SGDEMIFDPTMSK 13 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 S(1)GDEMIFDPTMSK;S(0.999)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(0.999)GDEMIFDPT(0.001)MSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK;S(1)GDEMIFDPTMSK 123.96 0.00016443 102115400.0 1719479.7 1662738.0 1794791.6 1882902.1 1868366.8 1454950.1 1468778.2 1540712.1 1356518.7 1728193.1 True False 1623917.9018966143 1790264.6580546643 1679316.662477341 1626447.5857927087 1633645.8591728837 1655356.2695530048 1537079.296628791 1545195.3171323827 1627860.3442993101 1678295.6748180778 0.9675994082941566 1.0667158861913433 1.000608347905904 0.9691067016358788 0.9733957393115286 0.9863317259233481 0.9158572709754529 0.9206931414512983 0.9699484832884201 1.0 20.678565475218747 -6.002321117174892 1.1971726211395293 0.9516585049109361 1.0198573423052404 0.2952110940789032 0.03394043462153134 0.5199920841706465 1.5157143001412596 0.012937812716472237 0.02504715336651688 9.946696869970716e-07 6.002321117174892 0.06819883739430432 (ac)S(ph)GDEMIFDPTMSKK ddPTM_A459_Selumetinib_30min_R1 12 SGDEMIFDPTMSKK 14 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK 121.36 5.6084e-05 413298500.0 38529.5 31861.680000000004 85996.1 85245.8 60073.41 47177.80999999999 41077.950000000004 41293.02 28839.469999999998 27579.74 True False 39427.16238464381 28131.299693506833 74318.30196276437 70359.2212918498 54639.780672321955 46703.24406542414 37979.407159452705 40197.79497096764 48938.47423844975 31119.868278417187 1.2669450279128607 0.9039658986287213 2.388130351255598 2.2609099968667477 1.7557844455985927 1.500753269505791 1.2204231335321194 1.2917083906440034 1.5725797358978684 1.0 14.92554833336724 -6.970249206879926 3.537526163617187 1.298668913488999 1.7358310459522384 0.19463719495678256 0.4225481231303774 0.4608637216355241 12.214616221819014 0.17958384378708622 0.1500217955127369 1.0709046223552849e-07 6.970249206879926 0.4371621324632393 (ac)S(ph)GDEMIFDPTMSKK ddPTM_A459_Selumetinib_30min_R2 5 SGDEMIFDPTMSKK 14 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(1)GDEMIFDPTMSKK;S(0.999)GDEMIFDPT(0.001)MSKK 87.184 0.0023231 24825000.0 160131.0 226812.0 198888.6 227226.0 191503.0 110891.0 83650.4 91310.8 65717.5 198031.0 True False 151231.56007518226 244207.75108447307 186092.3240095348 196277.4268132865 167444.68108145817 126165.22868172723 87540.30935012302 91576.4993106833 78862.8363003694 192313.33048367026 0.7863810568660692 1.2698430757258883 0.967651714738185 1.0206126965803488 0.8706868143790805 0.6560399550276635 0.45519626294213783 0.47618383541259124 0.4100747259798811 1.0 17.553099243126724 -6.694812563504817 2.0686303363922507 0.5412020902206399 1.0271174775573415 0.5096754616710208 0.19028555492966814 0.22382526212937595 1.967574437529014 0.07001829362836953 0.06734643236765545 2.0192376553581242e-07 6.694812563504817 0.4859153873367016 (ac)S(ph)GEDEQQEQTIAEDLVVTK ddPTM_A459_Selumetinib_30min_R1 12 SGEDEQQEQTIAEDLVVTK 19 0 Q9UQ80;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK 172.99 1.1996999999999994e-101 663975400.0 63688.700000000004 71201.5 77879.5 81588.3 70995.7 65067.90000000001 68281.4 63223.38 37069.130000000005 53737.02 True False 65172.52279336262 62865.19527932061 67303.89166147196 67340.43500707165 64574.151470308934 64413.37600292624 63130.87902432951 61546.49058391894 62903.606187864956 60634.68995990062 1.0748388890330436 1.036785960658743 1.1099898705836853 1.110592551089248 1.064970423911025 1.0623188812464377 1.041167672599294 1.0150376067663793 1.0374194414033424 1.0 15.887855795592232 -7.2890175761305365 1.37303356757876 1.0174152733546726 1.0809579309976356 0.6172370736951636 0.021533343556601015 0.3242343594842833 1.1882771884668848 0.014388149204380073 0.008205187403872313 5.140228483811951e-08 7.2890175761305365 0.06354265764296296 (ac)S(ph)GEDEQQEQTIAEDLVVTK ddPTM_A459_Selumetinib_30min_R2 8 SGEDEQQEQTIAEDLVVTK 19 0 Q9UQ80;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK;S(1)GEDEQQEQTIAEDLVVTK 160.69 4.8088e-39 72498500.0 630540.0 599915.7 674499.4 706939.8 723237.5 543773.1 516101.3 533528.8 461094.0 658962.0 True False 595497.111051611 645927.3051569898 631102.8429434188 610653.3797008226 632377.9394247143 618672.9086442697 540101.0330853248 535081.280477552 553325.6840427975 639936.0548711073 0.9305572119569869 1.009362263995407 0.9861967272191474 0.9542412480944168 0.9881892645540727 0.9667730141707356 0.8439921910543221 0.8361480438624845 0.8646577729617776 1.0 19.287568226534823 -7.217718515916208 7.938564568647782 0.8725991875636344 0.9749275718977444 0.4334442298933171 0.04731591162408714 0.23340169348989 38.90958446643731 0.017225555836821223 0.01324844146832891 6.057333482026034e-08 7.217718515916208 0.10232838433410996 (ac)S(ph)GEENPASKPTPVQDVQGDGR ddPTM_A459_Selumetinib_30min_R2 1 SGEENPASKPTPVQDVQGDGR 21 1 M0QZT2;M0R389;Q15102;M0QXS6;M0R323 M0QZT2 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 1 S(0.995)GEENPAS(0.005)KPT(0.001)PVQDVQGDGR 90.229 4.9426e-06 0.0 7830.2 5154.8 6678.8 8141.9 7429.2 6039.1 5254.8 6978.7 4912.5 5739.1 True False 7395.028830774132 5550.156584705575 6249.09327932762 7032.959174439093 6495.877478109323 6870.931207508446 5499.158612188666 6999.006861614023 5895.137266718382 5573.397271027431 1.3268440183182728 0.9958300682345632 1.12123593123582 1.261880112332742 1.1655148847682695 1.2328084422092203 0.9866798192864009 1.2557882600613157 1.0577278058686888 1.0 12.444341276856855 -8.492751352055977 8.266156557961331 1.0000139704167699 1.1600359351263958 0.22469711874782516 0.10545874909303123 0.35140725659579064 86.80818923095957 0.09671780923134708 0.02499601037235874 3.215500992317956e-09 8.492751352055977 0.16002196470962593 (ac)S(ph)GGKYVDSEGHLYTVPIR ddPTM_A459_Selumetinib_30min_R1 2 SGGKYVDSEGHLYTVPIR 18 1 Q03135 Q03135 CAV1 Caveolin-1 1 S(0.491)GGKY(0.491)VDS(0.018)EGHLYTVPIR;S(0.908)GGKY(0.091)VDS(0.001)EGHLYTVPIR 76.051 0.0020094 14431300.0 2685.5 2016.04 5318.700000000001 4073.2 4435.8 3631.1 3676.3 3759.0 1692.3400000000001 2275.6 True False 2748.066924926639 1780.001099568432 4596.449753527838 3361.89208343358 4034.5826732040996 3594.574430775012 3398.9937311938907 3659.2991090471787 2871.777376376823 2567.6954262210647 1.0702464540239613 0.6932290650173022 1.7901070767931915 1.3093032955163815 1.5712855317664705 1.39992243397233 1.3237526914149107 1.425129737615591 1.118426020099776 1.0 11.326258368298268 -5.245714815403515 24.998497358709862 1.3872562296471525 0.8817377419203306 0.4273046532423317 0.2238678390877829 686.6971825764305 1091689.0059679528 0.053248198613542554 0.13983387863845878 5.6791741266181055e-06 5.245714815403515 -0.5055184877268218 (ac)S(ph)HPSPQAKPSNPSNPR ddPTM_A459_Selumetinib_30min_R2 1 SHPSPQAKPSNPSNPR 16 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 S(0.994)HPS(0.006)PQAKPSNPSNPR 101.93 0.0011680999999999998 0.0 448.79 2052.4 752.76 622.22 896.88 747.04 719.65 761.2 0.0 1072.9 True False 423.84804844871445 2209.8124804938543 704.3282411431187 537.4725626106308 784.2059161910687 849.937979046069 753.1151509594225 763.4149659765566 0.0 1041.9225892710233 0.40679418299708614 2.120898906741181 0.6759890306590809 0.5158469238935218 0.7526527635222258 0.8157400442202952 0.7228129601128395 0.7326983538294113 0.0 1.0 10.025032379722465 -5.469335398530874 24.998416450017274 0.6474986459069447 1.2974965989257918 0.22276023286959112 0.4565610390970275 395.99512091948435 184881.88515663822 0.11038530286321507 0.22978280473699286 3.393630867966788e-06 5.469335398530874 0.6499979530188471 (ac)S(ph)KGPAVGIDLGTTYSCVGVFQHGK ddPTM_A459_Selumetinib_30min_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 S(0.991)KGPAVGIDLGT(0.006)T(0.003)YSCVGVFQHGK 73.796 4.9315e-13 42287000.0 3483.6 3223.2 4091.9 4344.4 3219.4 2968.8 3504.0 3279.0 1550.1 2948.6 True False 3564.7611020943727 2845.826245574972 3536.2424551978033 3585.732094488078 2928.2058384312336 2938.9365674547253 3239.690458913416 3192.030268306919 2630.4064851753838 3327.0815317962 1.0714378556782334 0.8553521211842946 1.0628661850942627 1.0777409751519493 0.8801124380172239 0.8833377058445796 0.9737334140905155 0.9594084899337075 0.7906047567626933 1.0 11.70004150527926 -6.275135112656941 24.875654245003332 0.9139035000675201 1.008600697392501 0.27504237965467193 0.08093230243623384 1085.467556210056 1971537.9219335972 0.025046229093022666 0.028540950070547723 5.307193073154734e-07 6.275135112656941 0.09469719732498094 (ac)S(ph)KS(ph)ESPKEPEQLR ddPTM_A459_Selumetinib_30min_R1 1 SKSESPKEPEQLR 13 2 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 2 S(1)KS(1)ESPKEPEQLR 92.239 0.011415 4330000.0 3512.5 5390.8 5199.4 5522.0 2577.5 4067.7 3744.3 3329.6 3394.2 4393.2 True False 3594.3344158647606 4759.642629885075 4493.350038259843 4557.68636077782 2344.3655800945858 4026.782631176093 3461.864436446774 3241.288191934955 5759.70949744035 4957.110013391803 0.7250866747267144 0.960164817207352 0.9064454946775247 0.919424089533029 0.4729299074987648 0.8123246448631566 0.6983634470678336 0.6538665035027473 1.161908749630389 1.0 12.275283561629209 -8.265882243180409 24.980063649195937 1.080954400394914 0.773848970060938 0.4367055908803589 0.14180940859220958 395.4288263913103 2223259.648135349 0.12709623644001003 0.03728751249375699 5.4214787121149946e-09 8.265882243180409 -0.3071054303339761 (ac)S(ph)KS(ph)ESPKEPEQLR ddPTM_A459_Selumetinib_30min_R2 1 SKSESPKEPEQLR 13 2 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 2 S(1)KS(1)ES(0.001)PKEPEQLR 86.882 0.004607 3790000.0 31411.0 29029.0 23338.0 22103.0 17861.0 16513.0 20787.0 18614.0 12700.0 18316.0 True False 29665.30236819574 31255.430957053264 21836.458488493146 19092.533270198273 15617.141500634065 18787.515859910745 21753.636688659095 18668.163658286405 15240.35486764854 17787.16948931685 1.6677921906581603 1.7571896965296017 1.2276522412184996 1.0733879430150726 0.8780003760583647 1.056239772786486 1.2229959748078267 1.0495297562379833 0.8568173186184598 1.0 14.11854932924268 -5.401934636922323 2.7349659582393153 1.0269902604956131 1.7254408340698748 0.8781630724061662 0.1015825999902548 0.09080091555242101 1.2940165475195688 0.02990134793580925 0.07605772046684017 3.96337680192209e-06 5.401934636922323 0.6984505735742617 (ac)S(ph)KSESPKEPEQLR ddPTM_A459_Selumetinib_30min_R1 8 SKSESPKEPEQLR 13 2 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.497)KS(0.497)ES(0.007)PKEPEQLR;S(0.976)KS(0.024)ESPKEPEQLR;S(0.94)KS(0.054)ES(0.007)PKEPEQLR;S(0.971)KS(0.029)ESPKEPEQLR;S(0.995)KS(0.005)ESPKEPEQLR;S(0.997)KS(0.003)ESPKEPEQLR;S(0.976)KS(0.024)ESPKEPEQLR;S(0.999)KS(0.001)ESPKEPEQLR 160.53 0.00038117 178798000.0 18022.79 20589.26 72041.70000000001 80470.6 27781.6 31609.599999999995 21273.800000000003 20823.699999999997 18796.5 16828.44 True False 18442.685940755393 18178.6598675127 62258.83283673207 66417.92033024416 25268.759185239862 31291.636123220447 19669.100138365353 20271.387831089585 31896.28765795699 18988.534196886812 0.9712537971350673 0.9573492971612894 3.2787592865877695 3.4977908058397387 1.3307377453801936 1.6479226779047926 1.0358408887395911 1.0675593819354996 1.6797656589620495 1.0 14.21284092176663 -6.465631094695297 24.9989977806229 1.2986240589906755 2.1987564889661098 0.22652086763035062 0.7987898051866809 472.8363841693172 206478.5875963545 0.2742568137992596 0.3109770818749037 3.422700555250494e-07 6.465631094695297 0.9001324299754343 (ac)S(ph)LDIQSLDIQCEELSDAR ddPTM_A459_Selumetinib_30min_R1 2 SLDIQSLDIQCEELSDAR 18 0 E9PMN0;E9PMA9;E9PIK5;E9PMJ3;E9PLZ3;E9PIM9;P13489;E9PR82;E9PMI1 E9PMN0 RNH1 Ribonuclease inhibitor 1 S(0.999)LDIQS(0.001)LDIQCEELSDAR;S(1)LDIQSLDIQCEELSDAR 211.38 3.0879e-12 4160800.0 214.37 132.3 167.76 63.523 110.1 135.89 142.11 114.32 0.0 54.359 True False 219.36440390859187 116.81025449539867 144.97911343971833 52.42990052439145 100.14147443973378 134.523069978248 131.39052828658265 111.28786223630584 0.0 61.33650715149888 3.5764084734523602 1.9044164710403497 2.363667580249155 0.854791101731495 1.6326569459259896 2.1931974320934358 2.142126025566682 1.8143821258264508 0.0 1.0 5.93867410859555 -2.274492270842693 0.8845986154415537 1.5011422043210778 199.99995705698754 0.46903022269259254 0.6730175509410744 174.55435407484205 1.8592185530043424 0.22990415729187638 68083.87894579092 0.0053150545864765674 2.274492270842693 198.49881485266647 (ac)S(ph)LPLNPKPFLNGLTGKPVMVK ddPTM_A459_Selumetinib_30min_R2 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 1 S(1)LPLNPKPFLNGLTGKPVMVK 64.705 0.0013693 10685000.0 15781.0 13870.0 13081.0 13127.0 12832.0 9167.6 13111.0 12524.0 9948.2 12708.0 True False 14903.955196348323 14933.784400920757 12239.382701515928 11339.079954661926 11219.92944046449 10430.35368481304 13720.68747895364 12560.44276654019 11938.117975932379 12341.087020650724 1.2076695652019203 1.2100866298026738 0.9917588848563654 0.9188072278955566 0.9091524451363022 0.8451730116933465 1.1117892172702766 1.0177744266386268 0.9673473621858395 1.0 13.591181854282626 -5.2843496226606534 4.686787306625029 0.965963644496994 1.2122530270043113 0.6686546695920479 0.0673267710921901 0.11162282758557074 6.603129417712955 0.01926999992795025 0.045740970740953686 5.195775495296565e-06 5.2843496226606534 0.24628938250731724 (ac)S(ph)LYPSLEDLKVDK ddPTM_A459_Selumetinib_30min_R2 1 SLYPSLEDLKVDK 13 1 B4DHN5;E9PBU7;O00560-2;O00560 B4DHN5 SDCBP Syntenin-1 1 S(0.96)LY(0.04)PSLEDLKVDK 140.17 0.00042286 1702300.0 9404.8 11292.0 10501.0 11578.0 10394.0 8332.6 8996.4 9395.8 5815.0 9720.8 True False 8882.118866397357 12158.060090497274 9825.377092624329 10001.056426835978 9088.212796461034 9480.340014188361 9414.750426028404 9423.140222441576 6978.162484675299 9440.135246328417 0.940888942226957 1.2879116424974897 1.0408089329488945 1.0594187652900124 0.9627206135627921 1.0042589186289022 0.9973109685785608 0.9981997054657188 0.7392015371166785 1.0 13.204591813508694 -6.560910905855475 0.6728478887268937 0.9136092777711157 1.1181787484870476 0.27702777978773907 0.10786235314637437 0.9592288861537842 0.96512821625504 0.0747099301120689 0.09699188664166652 2.7484579327562795e-07 6.560910905855475 0.2045694707159319 (ac)S(ph)QGDSNPAAIPHAAEDIQGDDR ddPTM_A459_Selumetinib_30min_R1 1 SQGDSNPAAIPHAAEDIQGDDR 22 0 P68402-3;P68402-2;P68402-4;P68402 P68402-3 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 1 S(0.5)QGDS(0.5)NPAAIPHAAEDIQGDDR 110.35 2.3858999999999996e-56 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 172.7 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 168.11943499134023 0.0 0.0 0.0 (ac)S(ph)QGDSNPAAIPHAAEDIQGDDR ddPTM_A459_Selumetinib_30min_R2 2 SQGDSNPAAIPHAAEDIQGDDR 22 0 P68402-3;P68402-2;P68402-4;P68402 P68402-3 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 1 S(0.816)QGDS(0.184)NPAAIPHAAEDIQGDDR;S(0.5)QGDS(0.5)NPAAIPHAAEDIQGDDR 110.35 7.534899999999998e-23 44094000.0 115676.0 108679.0 121679.0 134282.0 130240.0 101987.0 104881.0 97433.0 82382.0 120633.0 True False 109247.19100771747 117014.32984193701 113850.30561407821 115992.55995062947 113878.08683962729 116034.78350419167 109758.17431775888 97716.51389909856 98860.70194540334 117150.01184782498 0.9325410154428915 0.9988418097126254 0.971833496371874 0.9901199165161074 0.9720706386914596 0.9904803394720783 0.9369028016858597 0.834114417555757 0.8438812799594164 1.0 16.83799757454309 -7.547196270199889 5.640376789272372 0.8794035037927506 0.9764405190416 0.3932369647590309 0.04553977472713028 0.1437387767712208 13.853556418664587 0.020310691901877342 0.011852360563666776 2.836636780761232e-08 7.547196270199889 0.09703701524884945 (ac)S(ph)QKQEEENPAEETGEEK ddPTM_A459_Selumetinib_30min_R2 1 SQKQEEENPAEETGEEK 17 1 A6NMQ3;Q5T5H1;O43768-2;O43768;O43768-9;O43768-3;O43768-4;A0A1W2PRU0;O43768-8 A6NMQ3 ENSA Alpha-endosulfine 1 S(1)QKQEEENPAEETGEEK 165.35 3.6863e-11 8058000.0 53901.0 42003.0 44232.0 44788.0 37382.0 36163.0 56304.0 47310.0 31973.0 36668.0 True False 50905.39820279896 45224.495039068126 41386.161276160296 38687.797136390545 32685.738960679853 41144.12499497077 58922.24756425945 47447.66426740787 38368.49340026193 35609.299565094465 1.429553482503719 1.2700192250734084 1.1622290183075805 1.0864520675468083 0.9178989578531224 1.1554320219008674 1.6546870700601253 1.3324514901134927 1.0774852038334426 1.0 15.119966437718748 (ac)S(ph)QKQEEENPAEETGEEKQDTQEK ddPTM_A459_Selumetinib_30min_R1 2 SQKQEEENPAEETGEEKQDTQEK 23 2 A6NMQ3;Q5T5H1;O43768-2;O43768;O43768-9;O43768-3;O43768-4;A0A1W2PRU0;O43768-8 A6NMQ3 ENSA Alpha-endosulfine 1 S(1)QKQEEENPAEETGEEKQDTQEK;S(1)QKQEEENPAEETGEEKQDTQEK 112.58 8.5725e-08 20584900.0 998.36 1272.74 1388.0900000000001 1362.77 943.9 1309.55 989.0799999999999 956.72 709.07 1090.33 True False 1021.6198455296066 1123.7270091192258 1199.5950022325858 1124.7878018611361 858.5244116590798 1296.3771159762653 914.4728992871237 931.344677735466 1203.2400015762275 1230.284476213575 0.830393185707608 0.9133879446952795 0.9750549774671288 0.9142501784001013 0.6978259323415551 1.0537214286943637 0.7433019898792683 0.7570157111970145 0.9780177063433476 1.0 10.264776230283104 -4.7349706582846265 22.43057052728851 0.8824655457874307 0.8303922724832575 0.019058297683079095 0.11489488588705087 4082.983374264671 3459402.102997024 0.02790812460613937 1.7340239486718125 1.8408963715334633e-05 4.7349706582846265 -0.05207327330417322 (ac)S(ph)QKQEEENPAEETGEEKQDTQEK ddPTM_A459_Selumetinib_30min_R2 3 SQKQEEENPAEETGEEKQDTQEK 23 2 A6NMQ3;Q5T5H1;O43768-2;O43768;O43768-9;O43768-3;O43768-4;A0A1W2PRU0;O43768-8 A6NMQ3 ENSA Alpha-endosulfine 1 S(1)QKQEEENPAEETGEEKQDTQEK;S(1)QKQEEENPAEETGEEKQDTQEK;S(0.996)QKQEEENPAEET(0.004)GEEKQDTQEK 77.668 3.3519e-05 45334800.0 198156.0 168771.0 169964.0 166671.0 156721.0 105868.0 134338.0 134126.0 86978.0 154468.0 True False 187143.28280131778 181715.19301570312 159028.70128281112 143970.12227648793 137032.3068764835 120450.35602598131 140584.983185697 134516.28445424532 104376.03036837303 150008.10748393726 1.2475544551574116 1.21136914573208 1.060134041753975 0.959748940849108 0.9134993379684948 0.8029589736600006 0.9371825666206123 0.8967267617095244 0.6958025944001028 1.0 17.194680950563175 -5.517106209426821 1.108326072096499 0.8634267808076532 1.283950545333244 0.7718044446435766 0.0765938925941602 0.2986012368410594 0.6252198574329668 0.02616616414749273 0.11010073851826271 3.0401414491860506e-06 5.517106209426821 0.4205237645255908 (ac)S(ph)RHEGVSCDACLK ddPTM_A459_Selumetinib_30min_R1 2 SRHEGVSCDACLK 13 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 S(1)RHEGVSCDACLK;S(1)RHEGVSCDACLK 80.763 0.0020078 20002600.0 2833.4 2914.3 4043.6000000000004 4295.5 3576.3 3109.7 2801.0 2651.1000000000004 1700.19 2301.6 True False 2899.4127071633375 2573.092401178686 3494.501329904896 3545.371561521392 3252.8242964470487 3078.41924138169 2589.718314901961 2580.784216013563 2885.0982530355077 2597.0327794825125 1.1164328498545473 0.9907816418441214 1.345574594788601 1.365162422873941 1.2525156871894432 1.1853601793948474 0.9971835301277912 0.9937434122521213 1.11092100023874 1.0 11.342648508342794 -7.185857322531469 4.806147898057371 1.0250440000451242 1.2170104556436092 0.4226445918802375 0.10543759435871794 0.2448554503580587 10.470544255993763 0.046488696370964526 0.0353416868145747 6.518425067591501e-08 7.185857322531469 0.19196645559848502 (ac)S(ph)RHEGVSCDACLK ddPTM_A459_Selumetinib_30min_R2 1 SRHEGVSCDACLK 13 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 S(0.935)RHEGVS(0.065)CDACLK 53.754 0.0028041 8427000.0 66061.0 74238.0 75494.0 85531.0 90109.0 62383.0 44635.0 49031.0 37447.0 73615.0 True False 62389.594083135795 79931.81588720673 70636.79823165218 73881.53025079527 78788.70183531923 70975.69199350903 46710.61594257461 49173.67209248099 44937.44635660117 71489.54367525975 0.8727093624564126 1.1180910071309993 0.9880717458838295 1.0334592508577352 1.1021010596069238 0.9928122120336244 0.6533908812561027 0.6878442575581643 0.6285876793497087 1.0 16.125444622964814 -7.2070288202664194 6.0935362727499 0.7166653217071711 1.02736541086313 0.574018923296326 0.11532780491983535 0.13573428562040202 11.429758256315562 0.04196029476398292 0.032096040406392835 6.208278340352261e-08 7.2070288202664194 0.3107000891559589 (ac)S(ph)SAPTTPPSVDKVDGFSR ddPTM_A459_Selumetinib_30min_R2 1 SSAPTTPPSVDKVDGFSR 18 1 Q16537-2;Q16537 Q16537-2 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1 S(0.378)S(0.378)APT(0.122)T(0.122)PPS(0.001)VDKVDGFSR 45.28 0.027835 18156000.0 34310.0 31848.0 40357.0 42230.0 40947.0 24412.0 27452.0 31932.0 25725.0 33675.0 True False 32403.18755381223 34290.6391925396 37760.47455737927 36478.20114918666 35802.871789175486 27774.531409928008 28728.572395106046 32024.916833372816 30870.718816555785 32702.715251842386 0.9908408920872929 1.0485563332729002 1.1546586962760512 1.1154486980138927 1.0947981387312615 0.8493035271241969 0.8784766700216904 0.9792739406116626 0.9439802957895556 1.0 14.99712280480616 -6.745953870076473 24.988485698596737 0.9256783716389315 1.0850873752695482 0.6324384779365111 0.057328422915162096 158.24605026681417 255356.30458302266 0.020179508249268962 0.020110443751642473 1.7949242701068687e-07 6.745953870076473 0.15940900363061672 (ac)S(ph)SILPFTPPIVKR ddPTM_A459_Selumetinib_30min_R1 1 SSILPFTPPIVKR 13 1 P84022 P84022 SMAD3 Mothers against decapentaplegic homolog 3 1 S(0.5)S(0.5)ILPFT(0.001)PPIVKR 85.86200000000002 0.016352000000000002 10340000.0 3400.3 1798.9 11620.0 11142.0 7145.0 4225.3 3757.5 4317.2 3013.1 2562.8 True False 3479.5203741679593 1588.2839517140792 10042.067824091124 9196.258861243485 6498.736011552202 4182.797318265444 3474.068749819396 4202.693831758045 5113.010631883071 2891.760343785965 1.203253368366095 0.5492446686071704 3.4726487088289613 3.1801594074021753 2.2473286991147736 1.4464536548658875 1.2013681414798913 1.4533340706428575 1.7681308352091827 1.0 11.497732277767765 -6.780674072074886 8.108772811013383 1.389489732357702 2.1758980507187817 0.176536211799881 0.813920809632087 0.36444564801081364 116.09740316890522 0.3166115634909924 0.28648843797336687 1.657013046777281e-07 6.780674072074886 0.7864083183610797 (ac)S(ph)SNSASAANGNDSKK ddPTM_A459_Selumetinib_30min_R2 1 SSNSASAANGNDSKK 15 1 A6NLN1;K7ES59 A6NLN1 PTBP1 1 S(0.444)S(0.444)NS(0.11)AS(0.001)AANGNDSKK 80.014 1.9807e-13 0.0 3024.5 3511.6 4193.4 3454.0 4464.7 2487.7 2551.5 3221.3 2421.6 3362.5 True False 2856.4103980327936 3780.92842842634 3923.601209428707 2983.5592415176593 3903.8044710755767 2830.35809390783 2670.149805701336 3230.6734496850777 2905.9876651572977 3265.4158881757985 0.8747462791419525 1.157870408518937 1.2015624789590276 0.9136843035281499 1.1954999316354797 0.8667680291985685 0.8177058901961172 0.9893604858675048 0.8899288068267185 1.0 11.673051031900481 -6.780690505977431 24.99898226649499 0.906147219281489 1.072400437049966 0.3196166130845386 0.11347593931113877 281.0331801266833 364939.6745986308 0.03898621261751476 0.03443503217672269 1.656950345829311e-07 6.780690505977431 0.166253217768477 (ac)S(ph)SPASTPSRR ddPTM_A459_Selumetinib_30min_R2 1 SSPASTPSRR 10 1 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IS57;E5RFR3;E5RG53;A0A3B3IS88 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 S(0.5)S(0.5)PASTPSRR 76.221 0.047166 330730.0 0.0 0.0 0.0 0.0 564.88 538.25 358.37 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 493.9147243087268 612.3890517529801 375.0349150966833 0.0 0.0 0.0 0.0 (ac)S(ph)SPPEGK ddPTM_A459_Selumetinib_30min_R1 1 SSPPEGK 7 0 P51397;B4DQ75 P51397 DAP Death-associated protein 1 1 S(0.986)S(0.014)PPEGK 72.138 0.032987 38205000.0 1171.3 1365.5 1147.2 1282.6 1241.7 1107.4 1208.2 1208.9 889.01 1297.0 True False 1198.5890110469459 1205.626625196272 991.4165411185317 1058.617987383853 1129.3884542399412 1096.260561438751 1117.0645012726 1176.836044939382 1508.5850392786076 1463.482583849851 0.8189977962661684 0.8238066093173035 0.677436514830605 0.7233553709939223 0.7717129446590074 0.749076602302241 0.7632919678032927 0.8041339595880848 1.0308185802321677 1.0 10.515189861742568 -8.193652951973236 3.8131113221386768 1.018989960847432 0.7601695402776019 0.8549927532196966 0.04122729831198004 0.08324562421454967 2.2762606299943906 0.035668869109869175 0.011533519013671561 6.4024625677307846e-09 8.193652951973236 -0.2588204205698301 (ac)S(ph)SSAGSGHQPSQSR ddPTM_A459_Selumetinib_30min_R2 2 SSSAGSGHQPSQSR 14 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 1 S(0.497)S(0.497)S(0.005)AGSGHQPSQSR;S(0.737)S(0.228)S(0.035)AGSGHQPSQSR 131.42 2.2567e-27 2532970.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)S(ph)SSGTPDLPVLLTDLK ddPTM_A459_Selumetinib_30min_R1 2 SSSGTPDLPVLLTDLK 16 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 S(0.45)S(0.45)S(0.1)GTPDLPVLLTDLK;S(0.25)S(0.25)S(0.25)GT(0.25)PDLPVLLTDLK 169.65 1.0096e-08 30387300.0 12869.3 16272.2 13681.1 15742.2 13386.4 12508.7 13015.300000000001 11310.7 7021.9 10020.6 True False 13169.129650701316 14367.04325925946 11823.281764903015 12993.120287692258 12175.602483560868 12382.87383499088 12033.545442321853 11010.70349366852 11915.651440715454 11306.841618909655 1.1647045297492409 1.270650438335662 1.0456750137129065 1.1491379047852281 1.07683497248235 1.0951664710931883 1.0642711597018262 0.9738089437154694 1.053844375142535 1.0 13.464908371911653 -5.043008522933375 0.308701896024377 0.9933174040235871 1.3566696477875042 0.5964700645075154 0.052168422298066335 4.201178615628614 0.37044239844083554 0.05697079849394773 0.5693061176736518 9.057148262701802e-06 5.043008522933375 0.36335224376391706 (ac)S(ph)SSGTPDLPVLLTDLK ddPTM_A459_Selumetinib_30min_R2 2 SSSGTPDLPVLLTDLK 16 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 S(0.333)S(0.333)S(0.333)GT(0.002)PDLPVLLTDLK;S(0.25)S(0.25)S(0.25)GT(0.25)PDLPVLLTDLK 126.12 6.5941e-11 43946000.0 321720.0 366090.0 363900.0 361860.0 370240.0 270470.0 247160.0 275710.0 227890.0 348140.0 True False 303840.09034720086 394167.92583511706 340487.07018436206 312574.0437566814 323727.14121240465 307724.7874177958 258653.42973824887 276512.2704537526 273474.3677786159 338088.29362364917 0.898700416659287 1.165872741733833 1.007095118659693 0.9245337672194898 0.9575224795353874 0.9101906017495737 0.7650469851114542 0.8178699933383634 0.808884462835144 1.0 18.367040537921895 -6.414337749354131 1.1164939087647425 0.837005494678739 1.0331407464240128 0.3687568484770025 0.08807743605392955 0.4500277919467899 1.1791963537371366 0.03914086130650393 0.04999666363973895 3.851786889876154e-07 6.414337749354131 0.1961352517452738 (ac)S(ph)TEAQRVDDSPSTSGGSSDGDQR ddPTM_A459_Selumetinib_30min_R1 2 STEAQRVDDSPSTSGGSSDGDQR 23 1 F8WF15;F8W8F0;C9J180;Q96LR5 F8WF15 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 1 S(0.496)T(0.496)EAQRVDDS(0.007)PS(0.001)TSGGSSDGDQR;S(0.375)T(0.375)EAQRVDDS(0.187)PS(0.027)T(0.008)S(0.027)GGSSDGDQR 125.97 3.4024999999999985e-78 4475300.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)S(ph)TVHEILCK ddPTM_A459_Selumetinib_30min_R1 3 STVHEILCK 9 0 P07355;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YNP5;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK 78.49600000000002 0.0022307 69446100.0 27827.9 44149.2 38159.4 45414.1 43416.5 37456.4 37021.2 34698.2 13740.0 23506.199999999997 True False 28476.235926332534 38980.19113959377 32977.56307458031 37483.37996323799 39489.48524080564 37079.622623690135 34228.661078060875 33777.891020362 23315.77647010503 26523.44973977746 1.0736248944128284 1.469650121761304 1.243336119476327 1.4132166189160462 1.4888517756264146 1.3979939633599578 1.2905056247916287 1.2735104728743105 0.8790627425488377 1.0 14.694980809554876 -8.161039322149605 3.8873515027517347 0.9393749718219716 1.3481442332912323 0.63784875230435 0.1184151211195981 0.1386056943028637 3.60245761936161 0.08997358578560348 0.03009419567037365 6.901773105660752e-09 8.161039322149605 0.40876926146926074 (ac)S(ph)TVHEILCK ddPTM_A459_Selumetinib_30min_R2 6 STVHEILCK 9 0 P07355;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YNP5;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK;S(0.5)T(0.5)VHEILCK 77.282 0.0022404 94093800.0 772439.0 682558.0 800766.0 848953.0 753302.0 496433.0 524723.0 570068.0 450753.0 641607.0 True False 729509.932698315 734908.003830115 749245.587368099 733324.1368743898 658665.468154674 564812.1395799118 549123.6592188987 571726.8035001627 540916.1950911176 623082.1388148143 1.1708086097379402 1.1794721081686093 1.2024828520895567 1.176930120753053 1.05710856903641 0.9064810309829459 0.881302199198657 0.9175785468472322 0.8681298361721823 1.0 19.24906283583961 -6.537645763468891 2.4026656577106986 0.9056750151378771 1.1847640632638914 0.9291437317455497 0.03480739028900097 0.06593422927071457 0.7673421000807205 0.01191529598123627 0.012664444872702936 2.899707798329555e-07 6.537645763468891 0.2790890481260143 (ac)S(ph)TVHEILCKLSLEGDHSTPPSAYGSVK ddPTM_A459_Selumetinib_30min_R1 1 STVHEILCKLSLEGDHSTPPSAYGSVK 27 1 P07355;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 S(0.342)T(0.342)VHEILCKLS(0.313)LEGDHS(0.003)T(0.001)PPSAYGSVK 53.089 7.524600000000001e-10 143810000.0 1120.3 1240.4 1152.7 1319.9 1534.2 1370.6 1452.7 812.63 243.34 883.02 True False 1146.4008102756707 1095.1733913536846 996.1696713278689 1089.4042425915693 1395.431880885009 1356.8130084052307 1343.1216694245202 791.0764126057485 412.9302071495889 996.3642183431726 1.1505840827784741 1.0991697325048655 0.9998047430731432 1.093379531837374 1.4005238799175619 1.361764085287445 1.3480227859426357 0.793963089041082 0.4144370096271015 1.0 9.96052940189364 -7.8759377651338776 5.410466737543813 0.6770389014003553 1.203161802030519 0.5876238159681674 0.18108601347854764 0.14258965639849902 6.1146934340780765 0.1066407385967787 0.0500105426075827 1.3306450871876483e-08 7.8759377651338776 0.5261229006301638 (ac)S(ph)VELEEALPVTTAEGMAK ddPTM_A459_Selumetinib_30min_R1 2 SVELEEALPVTTAEGMAK 18 0 Q92522 Q92522 H1FX Histone H1x 1 S(1)VELEEALPVTTAEGMAK;S(1)VELEEALPVTTAEGMAK 133.71 3.1837e-12 7145300.0 1845.24 2071.17 2134.6099999999997 2695.73 1999.8600000000001 1920.26 1993.4499999999998 1678.39 1213.29 1693.63 True False 1888.230501787984 1828.676453539189 1844.7416865734224 2224.971360619269 1818.9730161039606 1900.943927856579 1843.0824615641966 1633.8736450209356 2058.8645148044916 1911.0239078532172 0.9880726735172881 0.9569092495517051 0.9653158597297434 1.1642823260744708 0.9518316378089359 0.9947253511820469 0.964447620979612 0.8549728961038361 1.0773619871230986 1.0 10.900130111918074 (ac)S(ph)YGRPPPDVEGMTSLK ddPTM_A459_Selumetinib_30min_R1 1 SYGRPPPDVEGMTSLK 16 1 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 S(0.55)Y(0.45)GRPPPDVEGMTSLK 72.958 0.011142 12945000.0 798.72 878.61 757.93 870.34 979.97 730.79 829.68 792.54 376.51 705.89 True False 817.3286219614242 775.7419327452925 655.0072690114795 718.3514573052098 891.3318865277563 723.4389161042304 767.0965696207999 771.5192646672656 638.9099707976156 796.4978574508648 1.0261529448142233 0.9739410162734146 0.8223591098007269 0.9018874948442962 1.1190637591674146 0.9082747798211858 0.9630867960848487 0.9686394727243317 0.8021490137367123 1.0 9.637526670735392 (ac)S(ph)YGRPPPDVEGMTSLK ddPTM_A459_Selumetinib_30min_R2 2 SYGRPPPDVEGMTSLK 16 1 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 S(0.566)Y(0.434)GRPPPDVEGMTSLK;S(0.567)Y(0.433)GRPPPDVEGMTSLK 87.001 0.0038621 18039600.0 34258.0 31127.0 37831.0 38843.0 40534.0 27806.0 30574.0 33728.0 23978.0 33979.0 True False 32354.077505639747 33514.34081092 35396.99464727842 33552.51639208754 35441.7565414423 31636.024102263575 31995.75158123165 33826.14289602901 28774.270001297376 32997.93798195554 0.9804878572513265 1.0156495484429011 1.0727032297180137 1.0168064565257158 1.0740597355150836 0.958727303492821 0.9696288173742273 1.0250986869096597 0.8720020631904994 1.0 15.010088253834068 -6.78097216875706 24.995992836987693 0.966943612422645 1.032459987995638 0.35639761602389164 0.044879998452031035 279.02113758978584 357059.1210466415 0.01532574843686529 0.013536514106257514 1.655876074909155e-07 6.78097216875706 0.06551637557299295 (ac)SASAPAAEGEGT(ph)PTQPASEKEPEMPGPR ddPTM_A459_Selumetinib_30min_R1 2 SASAPAAEGEGTPTQPASEKEPEMPGPR 28 1 D6R9L5;H0Y8X0;A0A494C198;B4DFG0;H0Y993;P35659;P35659-2 D6R9L5 DEK Protein DEK 1 S(0.094)AS(0.094)APAAEGEGT(0.716)PT(0.094)QPAS(0.001)EKEPEMPGPR;S(0.2)AS(0.2)APAAEGEGT(0.499)PT(0.101)QPASEKEPEMPGPR 61.109 4.0915e-05 38710000.0 4607.0 5221.2 3788.8 3441.5 4168.4 3986.8 5191.0 5455.1 3128.5 5149.4 True False 4714.334136338496 4609.899476729972 3274.30177038868 2840.506629955972 3791.368955990794 3946.696411724771 4799.438690701925 5310.413027337927 5308.836003400546 5810.375649403563 0.811364775842406 0.7933909535097234 0.5635266922414539 0.4888679839912848 0.6525170117666969 0.6792497851890008 0.8260117727835014 0.9139534769809663 0.9136820618380328 1.0 12.504415723681289 -7.472191370022168 1.8100611763975614 0.9466693728145098 0.6533341761191164 0.6548022713476427 0.09159467030384313 0.2567078014491092 1.6440003208057146 0.06301966524004814 0.032812762917655336 3.371387171768163e-08 7.472191370022168 -0.29333519669539343 (ac)SASAPAAEGEGT(ph)PTQPASEKEPEMPGPR ddPTM_A459_Selumetinib_30min_R2 2 SASAPAAEGEGTPTQPASEKEPEMPGPR 28 1 D6R9L5;H0Y8X0;A0A494C198;B4DFG0;H0Y993;P35659;P35659-2 D6R9L5 DEK Protein DEK 1 S(0.115)AS(0.062)APAAEGEGT(0.508)PT(0.304)QPAS(0.011)EKEPEMPGPR;S(0.038)AS(0.028)APAAEGEGT(0.678)PT(0.25)QPAS(0.006)EKEPEMPGPR 44.161 3.8372e-05 42119000.0 143003.0 89806.0 130014.0 152126.0 103934.0 102987.0 116554.0 134462.0 121169.0 111815.0 True False 135055.4657463657 96693.83142819702 121649.04078854024 131406.17636801253 90876.88173825105 117172.5244270956 121973.9919473694 134853.26215861746 145406.18574473305 108586.61041974035 1.2437580031673359 0.8904765611011163 1.1202950374664722 1.2101508267001189 0.8369068837029489 1.0790697303669992 1.1232875902091453 1.2418958620896596 1.3390802529213044 1.0 16.728486692938525 -7.527238820168555 3.1540889299175165 1.2164454268003264 1.055635522782551 0.13635983699443655 0.1421233150290924 0.41306199155347223 8.492356868349711 0.07030188553395561 0.03984393699788859 2.9700323506385044e-08 7.527238820168555 -0.1608099040177755 (ac)SCINLPTVLPGS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 SCINLPTVLPGSPSK 15 0 K7ERV3;P04183;K7ENW5;K7ES52;K7ERJ1 K7ERV3 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 SCINLPTVLPGS(0.901)PS(0.099)K;SCINLPTVLPGS(0.5)PS(0.5)K;SCINLPTVLPGS(0.767)PS(0.233)K 158.29 2.3983000000000003e-09 136410000.0 23708.8 26111.8 26928.9 28174.199999999997 24715.9 22829.4 22554.4 22194.4 13951.0 20950.8 True False 24261.168910705892 23054.618316953518 23272.103289859508 23254.104865234785 22480.35120894657 22599.756963436732 20853.10344934839 21605.732414428512 23673.828059274765 23640.039258073597 1.0262744763598548 0.9752360419232322 0.9844358985957085 0.9836745451805032 0.9509439034145865 0.9559948998696529 0.8821095101281016 0.9139465539190962 1.001429303937794 1.0 14.528944810893197 -6.194084845348907 1.5504289329412067 0.941083231516255 0.9956587387052401 0.23052883770811805 0.03599286565276679 0.5223051916685221 2.5024441830007365 0.013213239665410017 0.019065340406432152 6.396098667669357e-07 6.194084845348907 0.054575507188985184 (ac)SCINLPTVLPGS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 SCINLPTVLPGSPSK 15 0 K7ERV3;P04183;K7ENW5;K7ES52;K7ERJ1 K7ERV3 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 SCINLPTVLPGS(0.815)PS(0.185)K;SCINLPT(0.004)VLPGS(0.748)PS(0.248)K;SCINLPTVLPGS(0.8)PS(0.2)K 130.21 2.6502e-05 67579300.0 143630.0 139776.0 158684.0 164410.0 157202.0 125801.0 131697.0 138428.0 105507.0 146678.0 True False 135647.61959644582 150496.3697493223 148474.44420207595 142017.07437693034 137452.87935628896 143128.94584222318 137821.17145265464 138830.80256201088 126611.34811188956 142443.0250247882 0.95229387028842 1.0565373048145577 1.0423426782479392 0.9970096770425668 0.9649674270282392 1.0048154047368456 0.9675529667294749 0.9746409312625262 0.8888560748401434 1.0 17.12002545370816 -6.874954601804788 0.8608842861348346 0.9511321047362145 1.0174481844106 0.25193019893781865 0.03896314092622165 0.7768701365805752 1.2302429427566843 0.02606067646436999 0.021737600467480224 1.3336608367220324e-07 6.874954601804788 0.06631607967438558 (ac)SCINLPTVLPGSPS(ph)KTR ddPTM_A459_Selumetinib_30min_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ERV3;P04183;K7ENW5;K7ES52;K7ERJ1 K7ERV3 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 SCINLPT(0.003)VLPGS(0.341)PS(0.501)KT(0.155)R 140.68 2.7368e-07 29041000.0 775.02 300.92 4387.4 3743.2 1343.8 1333.5 645.4 751.46 828.82 341.75 True False 793.0764580735967 265.6881465060875 3791.6151782631173 3089.520388566379 1222.25352726716 1320.086200721125 596.7169583854793 731.528839713912 1406.4470053822736 385.61694142689817 2.056643193991883 0.6889950050507682 9.832594917207231 8.011889667332115 3.1696053672965094 3.4233096601938975 1.547434498540048 1.8970350135734084 3.6472645630609444 1.0 8.59102462509693 -6.5024760901319745 21.411664024794536 2.421247265209983 5.217091951382801 0.2167381417435108 2.552868950654901 213.71718207873346 224286.47614317643 0.8760658860507303 0.977811089201699 3.1442995233497017e-07 6.5024760901319745 2.795844686172818 (ac)SDAAVDT(ph)SSEITTK ddPTM_A459_Selumetinib_30min_R2 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 SDAAVDT(0.667)S(0.29)S(0.04)EIT(0.002)T(0.001)K 127.3 6.607400000000001e-06 27267000.0 100420.0 106720.0 96218.0 115650.0 112240.0 77960.0 92514.0 85276.0 70994.0 92218.0 True False 94839.05841311067 114905.08084111499 90027.43863423735 99898.27049262209 98139.40776166893 88698.2823495817 96816.08431301333 85524.13904179829 85194.78373809773 89555.42672886104 1.0589984535526407 1.2830610610455002 1.0052706119843007 1.1154909773929742 1.0958510427156676 0.9904288951480914 1.0810744568962274 0.954985556606548 0.9513078866346576 1.0 16.450493236412875 -6.58490837170606 0.57882742757517 0.9676546687093781 1.1559680806296662 0.3913247778945659 0.07336967079873172 0.8897442928638768 0.6486488205430926 0.056619659953638594 0.07909539698629205 2.600708207758913e-07 6.58490837170606 0.18831341192028805 (ac)SDAAVDTS(ph)SEITTK ddPTM_A459_Selumetinib_30min_R1 3 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 SDAAVDT(0.101)S(0.785)S(0.101)EIT(0.006)T(0.007)K;SDAAVDT(0.02)S(0.347)S(0.347)EIT(0.125)T(0.161)K;SDAAVDT(0.14)S(0.798)S(0.061)EITTK 109.83 0.00016713 32014100.0 7003.4 7804.299999999999 8597.7 9346.3 7746.200000000001 6918.5 8138.700000000001 6932.900000000001 3965.0 5478.5 True False 7166.565593755805 6890.56892787936 7430.179563785567 7714.144156779741 7045.55757770269 6848.906171495391 7524.791306495036 6749.016970767011 6728.315407857817 6181.718840109031 1.1593160056482614 1.1146687686879377 1.2019601272668874 1.247896314327308 1.1397408649498564 1.1079290968488293 1.2172652139517748 1.0917702900004385 1.0884214539493915 1.0 12.593792323004982 -8.409735864469743 1.0683591922923619 1.0013869351822522 1.169944493878749 0.5861859529007645 0.04456063989255647 0.367575819302972 0.9097238596519285 0.043879699407642775 0.014460747899968854 3.892818320937438e-09 8.409735864469743 0.1685575586964969 (ac)SDAAVDTSSEITTK ddPTM_A459_Selumetinib_30min_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 97.214 0.0018923 6643700.0 2313.2 2521.8 2548.8 2550.4 3000.1 2219.6 2680.5 2218.5 1280.1 1959.3 False True 2367.093059296332 2226.546483646986 2202.6869595562357 2105.020516937299 2728.7414847106766 2197.272839235554 2478.307726917069 2159.6581732964005 2172.2362051951554 2210.7952401981606 1.070697555457086 1.007124695748582 0.9963324144658471 0.9521553505554948 1.2342805136789108 0.9938834674886514 1.121002832761179 0.976869378958326 0.9825587488601843 1.0 11.110349696234026 -11.018870432309907 3.5749862293315227 0.9994028793917965 1.0378342214028495 0.018676433110112467 0.08080734179989528 0.00038538948726397914 5.433291869092822e-05 0.07840566851583008 0.018721035588850587 9.57479683781561e-12 11.018870432309907 0.03843134201105303 (ac)SDEFS(ph)LADALPEHSPAK ddPTM_A459_Selumetinib_30min_R1 1 SDEFSLADALPEHSPAK 17 0 Q8NDC0 Q8NDC0 MAPK1IP1L MAPK-interacting and spindle-stabilizing protein-like 1 S(0.392)DEFS(0.584)LADALPEHS(0.024)PAK 97.836 7.6869e-28 0.0 689.79 998.19 900.4 1108.2 907.61 945.88 728.46 839.59 531.16 647.41 True False 705.8607649023071 881.3214507540586 778.1306255431717 914.6736734903985 825.5168357515602 936.3653059903244 673.5116757134892 817.3213458273271 901.3397256085137 730.5113798074267 0.9662556729621135 1.20644451970945 1.0651861792328248 1.25210051311113 1.1300533551841154 1.2817942770955377 0.9219728731550173 1.1188345156824042 1.2338476176046975 1.0 9.51276293708668 -9.808864805285083 10.394143385681604 0.9999959567541911 1.1325251413053636 0.10632656920611028 0.11358509394345888 0.0 0.0 0.10558899232072307 0.025609092249463138 1.5528703391231495e-10 9.808864805285083 0.13252918455117257 (ac)SDEFS(ph)LADALPEHSPAK ddPTM_A459_Selumetinib_30min_R2 1 SDEFSLADALPEHSPAK 17 0 Q8NDC0 Q8NDC0 MAPK1IP1L MAPK-interacting and spindle-stabilizing protein-like 1 S(0.035)DEFS(0.952)LADALPEHS(0.013)PAK 101.53 8.366899999999999e-08 33121000.0 59203.0 52160.0 56398.0 66823.0 57303.0 45945.0 57204.0 54465.0 37202.0 56467.0 True False 55912.73426838665 56160.50427916564 52769.41408149955 57721.59212389531 50104.08484468026 52273.50670281592 59864.09934757561 54623.48413283384 44643.43951072919 54836.65099111463 1.019623431734487 1.0241417603760214 0.962301911727796 1.0526097250769042 0.9136970245101 0.9532585553280045 1.0916804411938943 0.9961126937107204 0.8141168124574735 1.0 15.742852844429414 -4.978547119516765 0.3273604162956403 0.9574694000948533 1.0653072570599342 0.08039978129648528 0.0709814177882165 19.90330609281613 1.9056500026412553 0.07743305896413183 0.8485267795743219 1.0506374579876976e-05 4.978547119516765 0.10783785696508097 (ac)SDEFSLADALPEHS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 SDEFSLADALPEHSPAK 17 0 Q8NDC0 Q8NDC0 MAPK1IP1L MAPK-interacting and spindle-stabilizing protein-like 1 SDEFSLADALPEHS(1)PAK;SDEFSLADALPEHS(1)PAK 166.36 1.7994999999999982e-275 651300000.0 11309.0 11879.5 12391.0 12963.900000000001 9555.4 9930.4 9661.5 9200.5 6113.1 8201.1 True False 11572.47769651661 10488.642617370278 10708.370258890978 10699.998227542128 8691.115757142888 9830.509192081789 8932.725276481722 8956.472852564137 10373.484216841262 9253.791070478805 1.2505661310459901 1.1334427736142503 1.157187381618387 1.1562826679410316 0.9391951569848007 1.0623223625010094 0.9653044042650436 0.9678706580200234 1.1209983171042701 1.0 13.175828811165598 -6.176418311509506 6.596588694093608 1.008365288380848 1.1718882104289836 0.6719104206310542 0.05654524007742584 0.1490153082429933 9.700351973784203 0.016224636716707905 0.021022020649808407 6.661648115855398e-07 6.176418311509506 0.16352292204813557 (ac)SDEFSLADALPEHS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 7 SDEFSLADALPEHSPAK 17 0 Q8NDC0 Q8NDC0 MAPK1IP1L MAPK-interacting and spindle-stabilizing protein-like 1 SDEFS(0.014)LADALPEHS(0.985)PAK;S(0.253)DEFS(0.007)LADALPEHS(0.74)PAK;S(0.078)DEFS(0.058)LADALPEHS(0.864)PAK;S(0.014)DEFS(0.085)LADALPEHS(0.901)PAK;S(0.02)DEFS(0.002)LADALPEHS(0.978)PAK;S(0.001)DEFS(0.005)LADALPEHS(0.994)PAK;S(0.009)DEFS(0.488)LADALPEHS(0.502)PAK 89.561 3.645e-50 120264600.0 149562.9 131167.9 153110.2 152931.0 157327.2 121988.8 132387.0 129713.9 105131.6 151521.6 True False 141250.79276572596 141228.05615872663 143259.25642578094 132101.5339793101 137562.35061298672 138791.64989592947 138543.25781986397 130091.34597370776 126160.857622337 147146.77770760428 0.9599312670400826 0.959776750527023 0.9735806563868613 0.8977534950973196 0.9348648523336147 0.9432190908843596 0.9415310343741513 0.8840923872095425 0.857381042166153 1.0 17.16689642421658 -5.75115805517554 24.99910782262144 0.9200097105132873 0.9639642862777122 0.2114194401323798 0.036681038448613625 319.8667934524418 777750.9219725385 0.010054886609970731 0.017167890906548244 1.773543907850785e-06 5.75115805517554 0.043954575764424964 (ac)SDFDEFER ddPTM_A459_Selumetinib_30min_R1 1 SDFDEFER 8 0 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 0 89.296 0.00017195 2245600.0 210.66 275.67 258.3 390.06 342.76 315.92 258.21 313.95 229.54 281.23 False True 215.56796812699528 243.39442824449378 223.22427874033892 321.9433433330309 311.7574185191931 312.74213163240955 238.73301181393643 305.62302614667783 389.5126150617108 317.3286099121769 0.6793209354386778 0.7670106654166955 0.7034483238120822 1.0145424436269115 0.9824434632776236 0.9855465970085815 0.7523211092753584 0.9631121071348131 1.227473990351867 1.0 8.30983378830004 -3.7377113170197696 0.3393617636167153 1.031841061536708 5.246252193280331e-08 0.49161681331641705 0.11817883362763192 12.994455529582355 0.6915103126872674 0.11717230246631734 6.309753167650057 0.00018293157896275643 3.7377113170197696 -1.031841009074186 (ac)SDKPDMAEIEKFDK ddPTM_A459_Selumetinib_30min_R1 1 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 86.46700000000001 0.0022589000000000003 132420000.0 3315.1 3271.0 3976.4 4891.6 3579.0 3786.9 2999.0 2889.9 2198.3 2911.5 False True 3392.3353799382967 2888.0297993533554 3436.426720801716 4037.3738867042384 3255.28008192377 3748.807224230095 2772.783015491248 2813.250464281841 3730.3545425205134 3285.2193854115967 1.0326054311630941 0.8790980024585243 1.0460265564185982 1.2289510723797237 0.9908866654017763 1.141113205674213 0.8440176104536937 0.85633564588545 1.1354963260857378 1.0 11.681774000925689 -7.257407209052632 24.99673442749092 0.9469903680138989 1.05004568275466 0.13658082448732245 0.11424090476726242 695.908487785529 4314178.792511139 0.04619743361957377 0.034455337676004935 5.5283151278393536e-08 7.257407209052632 0.10305531474076113 (ac)SDQDHS(ph)MDEMTAVVK ddPTM_A459_Selumetinib_30min_R1 1 SDQDHSMDEMTAVVK 15 0 P08047;H3BUU5;P08047-3 P08047 SP1 Transcription factor Sp1 1 S(0.229)DQDHS(0.77)MDEMT(0.001)AVVK 97.203 3.8881e-55 17262000.0 1769.1 2379.9 2576.5 2596.7 2475.6 1834.6 2568.6 2086.7 1025.7 1601.2 True False 1810.316587930634 2101.2602016145065 2226.625451701446 2143.2350910959385 2251.682417102679 1816.1455896835218 2374.8484340082755 2031.353937443137 1740.5379858360063 1806.7296170087745 1.001985339083442 1.1630186287051394 1.232406570822618 1.1862511528671806 1.24627525663224 1.0052116114033358 1.3144459534238884 1.124326472716073 0.9633638422984645 1.0 10.819164902991044 -8.173688066964166 4.6440501152583655 0.9823160003670903 1.167728488196069 0.36938782258287683 0.09347200036670476 0.2174580145796496 7.88652697959803 0.06721033965838173 0.0233913112959046 6.703659284506181e-09 8.173688066964166 0.18541248782897868 (ac)SDSGEQNYGERES(ph)R ddPTM_A459_Selumetinib_30min_R1 2 SDSGEQNYGERESR 14 1 P62995 P62995 TRA2B Transformer-2 protein homolog beta 1 SDSGEQNYGERES(1)R;SDSGEQNYGERES(1)R 119.88 4.8106e-05 20332000.0 200.49900000000002 0.0 0.0 0.0 71.797 0.0 0.0 0.0 0.0 0.0 True False 205.17023659685952 0.0 0.0 0.0 65.30297402678988 0.0 0.0 0.0 0.0 0.0 0.0 (ac)SDSGEQNYGERES(ph)R ddPTM_A459_Selumetinib_30min_R2 4 SDSGEQNYGERESR 14 1 P62995 P62995 TRA2B Transformer-2 protein homolog beta 1 SDSGEQNYGERES(1)R;SDSGEQNYGERES(1)R;SDSGEQNYGERES(1)R;S(0.001)DS(0.002)GEQNY(0.029)GERES(0.968)R 121.45 3.5452e-08 462933800.0 1692.5 0.0 1866.62 0.0 2117.0 940.02 2087.9900000000002 2275.01 784.57 1109.8 True False 1598.4376256143155 0.0 1746.523701422189 0.0 1851.0435337798724 1069.4992223480479 2185.085672273695 2281.6299024518203 941.5059227174024 1077.7571903933094 1.4831147867647188 0.0 1.6205168631580407 0.0 1.717495879665034 0.9923378214324434 2.0274378048698374 2.117016636761363 0.8735788831748046 1.0 10.073816472332902 -6.298563068831368 24.943159385600904 1.5160197410568979 0.7808145284708123 0.21162780767667422 0.6351579987690712 780.1370559097631 524166.82308396423 0.18630141979127124 0.21125139409356442 5.028482362476592e-07 6.298563068831368 -0.7352052125860855 (ac)SDVEENNFEGRES(ph)R ddPTM_A459_Selumetinib_30min_R1 2 SDVEENNFEGRESR 14 1 Q13595 Q13595 TRA2A Transformer-2 protein homolog alpha 1 SDVEENNFEGRES(1)R;SDVEENNFEGRES(1)R 126.56 0.00026277 14492800.0 659.61 925.52 1005.23 1163.1799999999998 749.4300000000001 869.73 696.6400000000001 702.72 554.11 1072.94 True False 674.9776296223644 817.1596881374252 868.7252873331431 960.0524485928189 681.6441888226126 860.9813058516569 644.0918839319182 684.081582843744 940.2841994068337 1210.662300320632 0.5575275858871653 0.674969137075639 0.7175620213027776 0.7929977239223179 0.5630341249100478 0.7111655377586585 0.5320161400593186 0.5650473981576627 0.7766692653746703 1.0 10.24158078338931 -8.571908290086613 4.583486266817551 0.9998774070798552 0.6452195528266587 0.6517332325109402 0.08132114532912672 0.16456998864555977 11.273010101857873 0.08146571493528454 0.02123948946563868 2.6797341442110996e-09 8.571908290086613 -0.3546578542531965 (ac)SDVEENNFEGRES(ph)R ddPTM_A459_Selumetinib_30min_R2 2 SDVEENNFEGRESR 14 1 Q13595 Q13595 TRA2A Transformer-2 protein homolog alpha 1 SDVEENNFEGRES(1)R;SDVEENNFEGRES(1)R 138.31 4.1632e-08 23822000.0 1965.98 1529.81 2060.95 3235.1 2843.75 1039.7 2062.17 1769.79 1668.25 3237.0 True False 1856.7187020414967 1647.1415078855518 1928.3507207926957 2794.473799141222 2486.49270155244 1182.9092375431005 2158.064991112334 1774.9397958954944 2001.9466147995804 3143.5393992639574 0.5906459141171373 0.5239767340823599 0.6134329734324973 0.8889577779096813 0.7909850603859582 0.3762985244657892 0.6865080143794708 0.5646310004293527 0.6368447665291949 1.0 11.618174129778305 -10.926805392935384 2.7198636299236547 1.0088194193926805 0.6312244739613931 0.40880425321380187 0.1333885013547815 10642426.866821475 11666614.764564728 729156.0266430362 0.03687630924187327 1.1835717946398657e-11 10.926805392935384 -0.37759494543128735 (ac)SEET(ph)VPEAASPPPPQGQPYFDR ddPTM_A459_Selumetinib_30min_R2 1 SEETVPEAASPPPPQGQPYFDR 22 0 P35612;A0A1C7CYY0;P35612-5;P35612-6;P35612-4;P35612-3;C9J299;C9J080;C9JTM0;P35612-7;P35612-2;P35612-8 P35612 ADD2 Beta-adducin 1 S(0.384)EET(0.575)VPEAAS(0.04)PPPPQGQPYFDR 123.68 2.5134e-09 7447000.0 12394.0 13557.0 11732.0 14925.0 12146.0 6779.9 8112.7 9220.4 7124.2 11391.0 True False 11705.191097113044 14596.778307374392 10977.175892835781 12892.189252938924 10620.11089338231 7713.769683195596 8489.956625010074 9247.229837480612 8549.23906677966 11062.112232627665 1.058133460496687 1.3195290375305757 0.9923218696388413 1.1654364900505576 0.9600436761126259 0.6973143574193594 0.7674806082665636 0.8359370835350899 0.7728396609070469 1.0 13.433339263909378 -6.48560788693765 3.7344669427900516 0.8018347068453023 1.1349257884280919 0.6586571171823656 0.10775052502736199 0.1308926366720362 3.8313145881773525 0.03408800392152685 0.03717702295080383 3.2688283288832837e-07 6.48560788693765 0.33309108158278955 (ac)SEETVPEAAS(ph)PPPPQGQPYFDR ddPTM_A459_Selumetinib_30min_R1 2 SEETVPEAASPPPPQGQPYFDR 22 0 P35612;A0A1C7CYY0;P35612-5;P35612-6;P35612-4;P35612-3;C9J299;C9J080;C9JTM0;P35612-7;P35612-2;P35612-8 P35612 ADD2 Beta-adducin 1 S(0.154)EET(0.198)VPEAAS(0.648)PPPPQGQPYFDR;S(0.021)EET(0.026)VPEAAS(0.953)PPPPQGQPYFDR 69.986 4.323e-05 5198100.0 572.07 784.27 604.7 676.81 625.89 529.35 756.39 794.54 328.15 583.6600000000001 True False 585.3981179455528 692.4473038027687 522.5850613793376 558.6178387971819 569.2783600098546 524.0252196113444 699.3348933269175 773.4662181703503 556.8465828722678 658.5784463298415 0.8888813795955339 1.0514272182177737 0.7935046527739033 0.8482176146369121 0.8644047845512667 0.7956914207132924 1.061885485661132 1.1744481200087264 0.8455281006772845 1.0 9.363211486582138 -7.273828872880904 24.869876016760486 1.03500278023335 0.8765425211399738 0.33161212654000627 0.10119894197773079 824.9197701375281 1655884.6853982147 0.0423019191881647 0.028744230959097762 5.3231796972742746e-08 7.273828872880904 -0.15846025909337613 (ac)SEGES(ph)QTVLSSGSDPK ddPTM_A459_Selumetinib_30min_R2 1 SEGESQTVLSSGSDPK 16 0 F8W6G1;Q9UHY1;C9JDW7;C9JHZ6 F8W6G1 NRBP1 Nuclear receptor-binding protein 1 S(0.333)EGES(0.667)QTVLSSGSDPK 105.17 1.3206e-06 3955500.0 44083.0 40190.0 38627.0 44269.0 51513.0 33207.0 33504.0 34213.0 27856.0 35612.0 True False 41633.04333823096 43272.44376878192 36141.78087389772 38239.485831715465 45041.47640793701 37780.96282686708 35062.00238691654 34312.55416573293 33427.97836167067 34583.78902891198 1.2038311737162695 1.2512348988887898 1.0450497729928683 1.105705502648866 1.3023869758829034 1.0924471808245841 1.0138276739314125 0.9921571675401935 0.9665794090325078 1.0 15.077808320066884 -7.126826238842478 3.3039233438679596 0.9913345738607355 1.1751424539645954 0.6231540219345442 0.06849831333276703 0.18470308231263713 3.7593163356034434 0.02952505083205134 0.02230321286707297 7.467474722008112e-08 7.126826238842478 0.18380788010385984 (ac)SET(ph)APAAPAAAPPAEK ddPTM_A459_Selumetinib_30min_R2 1 SETAPAAPAAAPPAEK 16 0 P16403 P16403 HIST1H1C Histone H1.2 1 S(0.264)ET(0.736)APAAPAAAPPAEK 47.242 0.0017779 18357000.0 137840.0 126010.0 120860.0 113200.0 107810.0 77837.0 87103.0 78623.0 66080.0 119540.0 True False 130179.40461723915 135674.56181398913 113083.99918241861 97781.96471910816 94265.94396637128 88558.34021606446 91153.46209132018 78851.77991326174 79297.84642946579 116088.56959777969 1.1213800382611396 1.1687159406311096 0.9741182923885511 0.8423048458422762 0.8120174474798095 0.7628515065944808 0.785206178413138 0.6792381040309575 0.6830805711898654 1.0 16.824866401882097 -5.605007473307324 1.4860383911446764 0.7673216282767394 1.1648169095717718 0.728202621418488 0.08608153111953934 0.20629252464245804 0.8826519963177338 0.02649258118420573 0.07571104843932344 2.4830903760923916e-06 5.605007473307324 0.3974952812950323 (ac)SETAPAAPAAPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 S(0.213)ET(0.213)APAAPAAPAPAEKT(0.573)PVK;S(0.264)ET(0.264)APAAPAAPAPAEKT(0.471)PVK 106.39 5.791699999999999e-09 1061490000.0 3992.5 5894.9 4460.5 4757.1 3112.2 3431.7 3263.9 2586.2 2162.5 2961.6 True False 4085.5174819473477 5204.722367535341 3854.7885997726717 3926.3617868265455 2830.702059503538 3397.1802137342984 3017.7013952190327 2517.6055748384715 3669.6045572490602 3341.750208426923 1.2225681834760898 1.5574839658603277 1.1535238600575275 1.1749417347009965 0.8470717088205245 1.0165871180818953 0.9030302108186502 0.7533793425043565 1.098108574361837 1.0 11.70638818247408 -5.825207358068467 1.6135090325687038 0.9259539388838226 1.3817663558900188 0.6351844328711422 0.1302740574963681 0.2157434230329058 1.1437386526209878 0.04006845687816056 0.08155801734788978 1.4955214345400485e-06 5.825207358068467 0.45581241700619624 (ac)SETAPAAPAAPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 4 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 S(0.28)ET(0.28)APAAPAAPAPAEKT(0.44)PVK;S(0.267)ET(0.267)APAAPAAPAPAEKT(0.465)PVK;S(0.118)ET(0.118)APAAPAAPAPAEKT(0.764)PVK;S(0.182)ET(0.182)APAAPAAPAPAEKT(0.636)PVK 58.93 0.000262 827311400.0 440587.2 514677.0 355759.6 352760.0 290270.3 240264.1 288477.7 241169.7 190834.0 460174.0 True False 416101.12723430473 554151.07095261 332870.4146577657 304713.47945505806 253803.94986459304 273358.29887465556 301892.484657718 241871.4638992067 229006.13234746805 446887.5809443603 0.9311091759475665 1.2400234300124902 0.7448638737159485 0.681857121227534 0.5679369055820616 0.6116936574898688 0.6755445833150263 0.5412355908125379 0.512446848183907 1.0 18.76955242707097 -5.422374359532553 4.4259426448675585 0.6363968724910948 1.0820722147491126 0.5679342152010408 0.14667484920678478 0.13730515162560666 4.473343304967147 0.03667972311912016 0.07946682025742216 3.7811650978035207e-06 5.422374359532553 0.44567534225801786 (ac)SETAPAAPAAPAPAEKT(ph)PVKK ddPTM_A459_Selumetinib_30min_R1 6 SETAPAAPAAPAPAEKTPVKK 21 2 P10412 P10412 HIST1H1E Histone H1.4 1 S(0.001)ET(0.001)APAAPAAPAPAEKT(0.998)PVKK;S(0.001)ET(0.001)APAAPAAPAPAEKT(0.998)PVKK;SETAPAAPAAPAPAEKT(1)PVKK;S(0.161)ET(0.161)APAAPAAPAPAEKT(0.678)PVKK;S(0.265)ET(0.265)APAAPAAPAPAEKT(0.47)PVKK;S(0.012)ET(0.032)APAAPAAPAPAEKT(0.956)PVKK 77.689 0.00012911 832255000.0 34199.8 49128.0 38556.7 46274.9 31123.300000000003 31292.0 29256.9 22652.500000000004 18363.7 29166.300000000003 True False 34996.58879877343 43376.070921012426 33320.91191679298 38193.857402455214 28308.20301026493 30977.230890862756 27050.02847813469 22051.68211430998 31161.857668418324 32910.0787088203 1.0634003372770398 1.3180178420353372 1.012483507305091 1.1605519920017329 0.8601681953035861 0.9412688181314037 0.8219375200365278 0.6700586257911277 0.9468788556882597 1.0 15.006241856412469 -6.260320102390038 1.4813323183898146 0.8425740622793708 1.1651075447217605 0.5326007186585181 0.1170781504895278 0.28076709444224035 1.2328130170127378 0.04213060036498963 0.05807344049127636 5.491359768527986e-07 6.260320102390038 0.32253348244238966 (ac)SETAPAAPAAPAPAEKT(ph)PVKK ddPTM_A459_Selumetinib_30min_R2 3 SETAPAAPAAPAPAEKTPVKK 21 2 P10412 P10412 HIST1H1E Histone H1.4 1 S(0.003)ET(0.003)APAAPAAPAPAEKT(0.994)PVKK;SETAPAAPAAPAPAEKT(1)PVKK;SETAPAAPAAPAPAEKT(1)PVKK 69.649 0.00017138 397378000.0 189312.0 204639.0 160472.0 155758.0 139872.0 119977.0 132219.0 99186.0 82416.0 203960.0 True False 178790.79691598058 220334.15328190484 150147.40622870298 134543.4917024633 122300.02888845476 136502.7427072313 138367.4454869783 99474.61483887385 98901.50289544245 198071.1448482785 0.9026594815359574 1.112399049597455 0.7580478536826509 0.679268511349914 0.6174550512248312 0.6891601642015636 0.6985744722835175 0.502216589473802 0.4993231243813959 1.0 17.595659197085055 -5.449040726736271 3.748730142526953 0.6509772497109916 1.0055010723762523 0.46987690208256416 0.14008758570264346 0.17822122839963353 4.758386701785865 0.036546328904232026 0.08009629139029864 3.5559797017422464e-06 5.449040726736271 0.3545238226652607 (ac)SETAPAETATPAPVEKS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 SETAPAETATPAPVEKSPAK 20 1 P16401 P16401 HIST1H1B Histone H1.5 1 S(0.005)ETAPAET(0.009)AT(0.001)PAPVEKS(0.985)PAK;SETAPAETAT(0.007)PAPVEKS(0.993)PAK 88.471 2.7006e-05 1013695200.0 224598.6 319560.0 207622.1 214038.0 123088.6 122516.0 166059.0 119623.8 94380.5 221108.0 True False 212116.30895143238 344069.2244526494 194263.9201278504 184885.6551638557 107625.10964195439 139391.4669104843 173781.07253966611 119971.88545321372 113259.23721150415 214724.0375324236 0.9878554417523122 1.6023787015493993 0.9047143596976949 0.8610384626171056 0.5012252511584916 0.6491656384275841 0.809322861737941 0.5587259201713632 0.5274641745426469 1.0 17.712124178850402 -5.594033346404513 2.4573279631124496 0.6685200965116702 1.2932407858423816 0.5532314947007162 0.20733925997230204 0.18388269505835383 2.2272524194110788 0.05610007263176124 0.12051136604395407 2.5466347069933894e-06 5.594033346404513 0.6247206893307113 (ac)SETAPAETATPAPVEKS(ph)PAKK ddPTM_A459_Selumetinib_30min_R1 4 SETAPAETATPAPVEKSPAKK 21 2 P16401 P16401 HIST1H1B Histone H1.5 1 S(0.012)ET(0.001)APAET(0.002)AT(0.041)PAPVEKS(0.944)PAKK;S(0.022)ET(0.005)APAET(0.005)AT(0.017)PAPVEKS(0.952)PAKK;S(0.042)ET(0.011)APAET(0.05)AT(0.02)PAPVEKS(0.877)PAKK;SETAPAETATPAPVEKS(1)PAKK 81.553 0.00012217 818222000.0 21779.4 40057.4 31974.699999999997 36809.700000000004 25765.8 26366.1 24207.800000000003 18951.5 15881.099999999999 24343.9 True False 22286.817644664767 35367.46098581995 27632.711364454935 30381.576898646057 23435.287939321464 26100.880972503375 22381.786156188413 18448.84465685226 26949.066790348235 27468.67669466644 0.8113538883725029 1.2875560544453606 1.0059716990232859 1.1060444314940447 0.8531640675603375 0.9502052560679544 0.8148112268012626 0.671632087046787 0.9810835479956304 1.0 14.745499789707386 -6.266836862764991 24.33279656689358 0.8624668455124278 1.0661647148075477 0.2622698839458124 0.14093087136236643 361.41602372483374 1629324.7652433203 0.041591371574404 0.04858029102881721 5.409574886307275e-07 6.266836862764991 0.2036978692951199 (ac)SETAPAETATPAPVEKS(ph)PAKK ddPTM_A459_Selumetinib_30min_R2 2 SETAPAETATPAPVEKSPAKK 21 2 P16401 P16401 HIST1H1B Histone H1.5 1 SETAPAETATPAPVEKS(1)PAKK;S(0.006)ET(0.001)APAET(0.006)AT(0.008)PAPVEKS(0.98)PAKK 60.464 0.001225 263496000.0 622060.0 727800.0 566420.0 455380.0 412190.0 315480.0 403350.0 365890.0 220741.0 636230.0 True False 587488.3955034805 783619.9197541539 529977.1538714668 393356.45842568355 360407.00717464637 358934.5063576965 422106.57422286243 366954.67932365014 264895.36801886646 617860.3867759379 0.9508432779920691 1.2682799165085938 0.8577619883303164 0.6366429485441848 0.5833146369122141 0.58093141110835 0.6831746835647776 0.5939119697225764 0.42873013659464243 1.0 19.23692135453915 -5.5505032562204875 3.307451733201784 0.6238309694437355 1.1085264581352658 0.5865139265520718 0.15534536255386636 0.14194418767030675 3.2127489343535878 0.04036376503176483 0.0817913048811722 2.8151189080674504e-06 5.5505032562204875 0.48469548869153034 (ac)SETAPLAPTIPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 5 SETAPLAPTIPAPAEKTPVK 20 1 P16402 P16402 HIST1H1D Histone H1.3 1 SETAPLAPT(0.001)IPAPAEKT(0.999)PVK;SETAPLAPT(0.016)IPAPAEKT(0.983)PVK;S(0.001)ETAPLAPT(0.127)IPAPAEKT(0.872)PVK;SETAPLAPT(0.051)IPAPAEKT(0.949)PVK;S(0.272)ET(0.272)APLAPT(0.103)IPAPAEKT(0.353)PVK 82.885 0.00043377 228873600.0 38865.3 59057.4 43738.3 50269.0 36762.3 37246.100000000006 34580.1 28134.399999999998 22374.9 34315.6 True False 39770.78587129073 52142.932152959605 37798.87909728441 41490.4628159979 33437.15645591123 36871.43805075299 31971.695216401757 27388.184318589236 37968.571101961614 38720.34152224974 1.0271290052655495 1.3466547582747141 0.9762021100863525 1.0715417577646202 0.8635553081756097 0.9522498149858952 0.8257079860215067 0.7073332321423677 0.9805846128744463 1.0 15.240804057117616 -5.916367623209057 1.2095710182317814 0.865870056236345 1.1773849039655209 0.443205066125276 0.11978418618385939 0.39269847978261746 1.1605913342415115 0.0424546320089605 0.09078142161936785 1.2123621711507671e-06 5.916367623209057 0.3115148477291758 (ac)SETAPLAPTIPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 SETAPLAPTIPAPAEKTPVK 20 1 P16402 P16402 HIST1H1D Histone H1.3 1 S(0.003)ET(0.003)APLAPT(0.002)IPAPAEKT(0.993)PVK;S(0.101)ET(0.101)APLAPT(0.006)IPAPAEKT(0.792)PVK 86.539 1.4077e-08 0.0 87223.0 94317.0 76160.0 70044.0 65512.0 49800.0 58056.0 48751.0 40107.0 87010.0 True False 82375.49484133392 101550.81062304573 71259.9485167382 60503.88636736049 57281.79687528914 56659.49796061013 60755.71903578155 48892.857338837464 48129.520683211 84497.79522087038 0.9748833638322877 1.201816098959744 0.8433350045462189 0.7160410068595072 0.6779087753184467 0.6705440989614795 0.7190213528882148 0.5786287939352205 0.5695949883355458 1.0 16.366626077566586 -5.505249186910475 3.124642140348622 0.6855820581556734 1.0872043757845835 0.5942753918610715 0.1243386561325793 0.14840966879124767 2.9375113098929306 0.03265581199857278 0.07070011351685732 3.124286218336958e-06 5.505249186910475 0.4016223176289101 (ac)SETAPLAPTIPAPAEKT(ph)PVKK ddPTM_A459_Selumetinib_30min_R1 2 SETAPLAPTIPAPAEKTPVKK 21 2 P16402 P16402 HIST1H1D Histone H1.3 1 SETAPLAPT(0.001)IPAPAEKT(0.999)PVKK;S(0.008)ET(0.003)APLAPT(0.476)IPAPAEKT(0.513)PVKK 81.477 6.7181e-05 942160000.0 10410.8 15164.8 12709.2 14630.3 10135.6 9717.1 9008.5 7333.9 6134.9 8668.7 True False 10653.351384109576 13389.298166075747 10983.360446638468 12075.39274974426 9218.836769585523 9619.354796420881 8328.981592215041 7139.381148135439 10410.47722463226 9781.412085288513 1.0891424766913236 1.3688512506505663 1.122880863301702 1.2345244883308772 0.9424852658493841 0.9834321172183952 0.8515111641949976 0.7298926868517528 1.0643123031581376 1.0 13.255827038324876 -6.311990633524439 4.2248248622502835 0.909924485275583 1.2111650504264335 0.5957162037484058 0.11046767077001461 0.1434435295434676 5.490965245762331 0.03420640212549674 0.04006715734924723 4.875390047958837e-07 6.311990633524439 0.3012405651508505 (ac)SETAPLAPTIPAPAEKT(ph)PVKK ddPTM_A459_Selumetinib_30min_R2 4 SETAPLAPTIPAPAEKTPVKK 21 2 P16402 P16402 HIST1H1D Histone H1.3 1 SETAPLAPTIPAPAEKT(1)PVKK;SETAPLAPTIPAPAEKT(1)PVKK;SETAPLAPT(0.008)IPAPAEKT(0.992)PVKK;SETAPLAPTIPAPAEKT(1)PVKK 96.504 2.9738e-06 328487000.0 594320.0 591042.0 540152.0 496760.0 429877.0 338941.0 413934.0 330757.0 242979.0 592610.0 True False 561290.0736514633 636373.0209004324 505399.20839303144 429100.4310412018 375872.0081108597 385627.04614994285 433182.7511946604 331719.44811023097 291581.5894005025 575499.8095143074 0.9753088782516949 1.1057745117891504 0.8781917909226811 0.7456135066375448 0.6531227324437806 0.6700732819970739 0.7527070279315029 0.5764023595249933 0.506658012009739 1.0 19.13445592527423 -5.635622593725478 2.1469844882700477 0.6752975571149747 1.0420477285429053 0.5343804332637869 0.1273271144744391 0.21765773710144914 2.0200967915621075 0.036173528511463736 0.07894755501362963 2.3140748710053325e-06 5.635622593725478 0.36675017142793054 (ac)SGAGVAAGTRPPSS(ph)PTPGSR ddPTM_A459_Selumetinib_30min_R1 1 SGAGVAAGTRPPSSPTPGSR 20 1 B8ZZB0;F5GZA4;E7ESC5;Q96AQ1-2;Q96LY2-2;Q96AQ1;Q96LY2;F8WCQ0;F8WB40;F8WEI8;C9JC78;E9PG54 B8ZZB0 CCDC74B;CCDC74A Coiled-coil domain-containing protein 74A;Coiled-coil domain-containing protein 74B 1 S(0.01)GAGVAAGT(0.018)RPPS(0.204)S(0.572)PT(0.153)PGS(0.044)R 44.468 0.00037713 4462800.0 329.9 447.83 489.28 508.91 642.54 465.15 704.75 364.68 232.43 250.99 True False 337.58602812634433 395.3978554094811 422.8384634226597 420.03842192383934 584.422370449651 460.47101332240834 651.5901401025195 355.0075017524144 394.41673398446176 283.2070113496331 1.192011548434363 1.3961443028023868 1.493036706286359 1.483149798877264 2.063587224287158 1.6259167141661406 2.3007556804379368 1.2535265283885928 1.3926799767592433 1.0 8.145713172406557 -8.378984645082319 1.9232776650340775 1.0427874163676514 1.6367875581088482 0.251196199424385 0.32365186654551864 0.4551909828970047 3.41653401327475 0.3187288557548521 0.09126487066928689 4.178451397201255e-09 8.378984645082319 0.5940001417411969 (ac)SGDEMIFDPTMSK ddPTM_A459_Selumetinib_30min_R1 2 SGDEMIFDPTMSK 13 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 ; 80.763 0.0086443 5452400.0 4707.1 5253.0 5885.9 6124.4 5236.4 4379.2 5240.0 4397.2 2970.3 3843.8 False True 4816.766271577799 4637.976317946553 5086.62710893442 5054.888509226309 4762.768544561509 4335.149223995463 4844.742581251795 4280.571971881422 5040.382157871391 4337.189171782619 1.1105732493558886 1.069350709468895 1.1727934631091443 1.1654756822951096 1.0981233134924508 0.9995296613298705 1.11702358125656 0.9869461077995988 1.1621310388450856 1.0 12.082544654134896 -6.528709905941938 24.612055039435187 1.0554729799242542 1.1287701595586734 0.28220046500315843 0.057631937242105725 169.599084142841 715833.0080526064 0.018113724468361434 0.018168803650239713 2.959988979105463e-07 6.528709905941938 0.07329717963441928 (ac)SGEDEQQEQTIAEDLVVTK ddPTM_A459_Selumetinib_30min_R1 2 SGEDEQQEQTIAEDLVVTK 19 0 Q9UQ80;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 ; 176.91 6.677499999999996e-85 6226700.0 2001.63 2117.0 2226.96 2325.48 2741.1000000000004 1659.05 2236.6 1942.46 1003.37 1745.65 False True 2048.2640845060173 1869.1406558333997 1924.5510638156604 1919.3785726659926 2493.1679889805114 1642.361463296876 2067.89146130301 1890.9396508006887 1702.6456067546774 1969.7211815709268 1.0398751374915152 0.9489366684591825 0.97706776056536 0.9744417588763583 1.2657466510016997 0.8338040320950557 1.0498396832255157 0.9600037144813527 0.8644094517970068 1.0 10.943775712093343 -7.983274859049043 9.93070990202135 0.9255311652751601 1.0100076158589255 0.08823162861066092 0.10690658860894298 0.6132898001515923 345.6606138700956 0.058055652291249295 0.02734112893268127 1.0392622227756045e-08 7.983274859049043 0.0844764505837654 (ac)SGGSSCSQTPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SGGSSCSQTPSR 12 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 SGGSSCSQT(0.016)PS(0.984)R 172.57 1.5753e-06 3235800.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)SGYSS(ph)DRDR ddPTM_A459_Selumetinib_30min_R2 2 SGYSSDRDR 9 1 P17844-2;P17844;J3QR02;J3KRX8;J3QRQ7;X6RLV5;J3QS79;J3QKN9 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 1 SGYS(0.139)S(0.861)DRDR;SGYS(0.198)S(0.802)DRDR 66.19 0.026524 1253490000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)SHTILLVQPTK ddPTM_A459_Selumetinib_30min_R2 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 70.55199999999998 0.00022072 4013600.0 48175.0 39371.0 47925.0 51264.0 57944.0 37528.0 38996.0 34914.0 30839.0 46240.0 False True 45497.62635980482 42390.62910228199 44841.55767679464 44281.75476466744 50664.556694067534 42697.1413547345 40809.39126910807 35015.59395967614 37007.661713654605 44904.931054051754 1.0131988913431276 0.9440083328767767 0.9985887211989963 0.9861223194255838 1.1282626541188308 0.9508341367530494 0.9087953218319407 0.7797716896063844 0.8241335827708707 1.0 15.454586256957175 -7.2689740364046544 2.81707168074623 0.8530231529175138 1.0086547649792579 0.43932124015675356 0.07039300059968598 0.2316448138099016 3.6852863101058215 0.03170569534315096 0.021334800330142782 5.383019630692532e-08 7.2689740364046544 0.15563161206174403 (ac)SKGPAVGIDLGT(ph)TYSCVGVFQHGK ddPTM_A459_Selumetinib_30min_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 S(0.34)KGPAVGIDLGT(0.484)T(0.16)Y(0.007)S(0.008)CVGVFQHGK 64.377 7.0392e-13 46551000.0 3192.6 3171.9 3715.7 4144.4 3292.1 3416.2 3341.7 3362.7 1641.4 2656.1 True False 3266.981368281805 2800.532473423696 3211.1283488791205 3420.6583400231075 2994.3301362674633 3381.836129661426 3089.632878581895 3273.510272411 2785.335916887217 2997.0363076049257 1.090070667476366 0.934433949404415 1.0714345838023183 1.1413469804630823 0.9990970508663524 1.1283934469128978 1.0308960457842993 1.0922491209414202 0.9293634213971573 1.0 11.549320846152643 -8.260684607236422 24.99871389307664 0.9646817076081184 1.05897892031518 0.2902395493223119 0.060176675859039394 84.49736848254086 2798903.6494980296 0.04550162092168108 0.01489086370598567 5.486752785061953e-09 8.260684607236422 0.0942972127070616 (ac)SKGPAVGIDLGTT(ph)YSCVGVFQHGK ddPTM_A459_Selumetinib_30min_R2 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 S(0.29)KGPAVGIDLGT(0.125)T(0.537)Y(0.035)S(0.013)CVGVFQHGK 57.806 9.0887e-08 3223600.0 26982.0 22720.0 22503.0 24538.0 24470.0 15210.0 21505.0 21738.0 17654.0 18432.0 True False 25482.448457503975 24462.55094368564 21055.181479413877 21195.882069588984 21395.859835424428 17305.03943736708 22505.025111349078 21801.25398108038 21185.29329397379 17899.820267912663 1.4236147668579657 1.3666366800083112 1.1762789326526109 1.1841393797447712 1.1953114341476818 0.9667716869977856 1.2572765968880557 1.2179593791878152 1.1835478220946547 1.0 14.127657481011445 -5.205951457039421 2.2750694561980187 1.1516074553673872 1.4283472139512894 0.5650752292003166 0.08768858863722746 0.25429790755924403 2.407787767866597 0.024096559986629396 0.09610514622846955 6.223698462338023e-06 5.205951457039421 0.2767397585839022 (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_A459_Selumetinib_30min_R1 2 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 59.011 2.0655e-16 255520000.0 7524.700000000001 6882.9 7653.0 8811.2 8538.0 6544.0 6154.6 6542.799999999999 2617.3 4418.4 False True 7700.010869482588 6077.046868226597 6613.764634919916 7272.489326708716 7765.73940750633 6478.173301476602 5690.353566903116 6369.263689990395 4441.366939971313 4985.544678860587 1.5444673281400367 1.2189333883605804 1.3265881786123013 1.4587151043987425 1.5576511510235103 1.2993912839543835 1.1413704887714713 1.2775462061341003 0.8908488893507134 1.0 12.283535414674569 -7.762816368436714 1.0888083950797487 0.9660890326895525 1.402713681297619 0.6546912200945786 0.12236207213157402 0.3394308531134778 0.7276704628048742 0.10875873082618417 0.04324113046524388 1.726567777663621e-08 7.762816368436714 0.4366246486080666 (ac)SLLDGLASS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SLLDGLASSPR 11 0 E9PI10;E9PK87;F8W6N5;Q3YBR2 E9PI10 TBRG1 Transforming growth factor beta regulator 1 1 SLLDGLAS(0.146)S(0.854)PR;SLLDGLAS(0.09)S(0.91)PR 124.38 0.00041915 4463000.0 366.69 374.34 519.51 591.55 409.45000000000005 341.75 387.14 445.98 123.54 320.62 True False 375.23316354546614 330.51209877405523 448.9633954641634 488.2468972687651 372.41531979426867 338.3123052841732 357.93771811179795 434.15116165279625 209.6383569953984 361.7747001032686 1.0372012289371144 0.913585440551013 1.2410027437960887 1.3495882855528456 1.029412282528222 0.9351463913524134 0.9893940013207796 1.200059488761563 0.5794721326161203 1.0 8.49894770964158 -6.5154580340349 23.82732366804463 0.9592348508413153 1.1348576138033581 0.20414084718998116 0.17923226500309833 345.8758024311436 1110588.2069003454 0.05884370929291586 0.061327556088235924 3.05170090137972e-07 6.5154580340349 0.17562276296204282 (ac)SLLDGLASS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SLLDGLASSPR 11 0 E9PI10;E9PK87;F8W6N5;Q3YBR2 E9PI10 TBRG1 Transforming growth factor beta regulator 1 1 SLLDGLAS(0.048)S(0.952)PR 94.781 0.0023546 626750.0 761.93 817.69 1266.9 1088.8 1223.3 703.97 1230.9 825.94 639.14 1255.7 True False 719.5849808474544 880.4041937122496 1185.3890332964252 940.5035617152366 1069.6181175592442 800.935477496601 1288.139288982079 828.3433486582721 766.9858590636923 1219.4446782995847 0.590092354046644 0.7219714099207033 0.9720728249430328 0.7712556202440373 0.877135417943468 0.6568034546785999 1.056332699551638 0.6792791533711302 0.628963226222932 1.0 10.252008594536068 -4.9538861074828855 4.540754384967237 0.8219719169558157 0.6052575826164782 0.21816010953288856 0.14157450498177318 0.3120616165165764 13.945116205466096 0.034524132005051306 0.1525614950009343 1.1120233140599254e-05 4.9538861074828855 -0.2167143343393375 (ac)SLYPS(ph)LEDLKVDK ddPTM_A459_Selumetinib_30min_R2 1 SLYPSLEDLKVDK 13 1 B4DHN5;E9PBU7;O00560-2;O00560 B4DHN5 SDCBP Syntenin-1 1 S(0.158)LY(0.08)PS(0.761)LEDLKVDK 82.20200000000001 0.02782 0.0 10014.0 10393.0 9956.2 11063.0 9625.4 7598.2 7903.5 8186.0 5540.2 7344.0 True False 9457.461969218177 11190.109681237891 9315.628931490928 9556.200315260523 8416.171199832215 8644.783080407795 8271.028410488147 8209.819904734752 6648.3948061217625 7131.959637996449 1.3260677919196724 1.5690091151976122 1.3061808260748835 1.3399122822216512 1.1800643339306018 1.2121189012836782 1.1597132948458038 1.1511310104723338 0.9321974805776478 1.0 12.80008282298294 -6.629280765471188 0.42657538136105305 0.9747638014193 1.5018831277967832 0.7745753915486095 0.08169583434733489 0.628497657565293 0.23101039659663342 0.07772641774720493 0.13730314538308588 2.3481143061138962e-07 6.629280765471188 0.5271193263774833 (ac)SNGYEDHMAEDCR ddPTM_A459_Selumetinib_30min_R2 1 SNGYEDHMAEDCR 13 0 Q15717;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 130.01 3.5322e-12 4169500.0 4912.9 1917.5 4704.3 7939.0 6320.9 4971.8 1434.6 5470.8 4694.0 6796.2 False True 4639.860685896944 2064.5660842657207 4401.630459654565 6857.69450446112 5526.812032437034 5656.620320493202 1501.3117426059716 5486.719122260305 5632.931161318289 6599.976047351783 0.7030117461954536 0.3128141783323775 0.6669161263730198 1.039048392791175 0.8373988015690826 0.8570667953807046 0.22747230169242322 0.8313240961627174 0.8534775158128768 1.0 12.688245073310526 -14.502992554973066 0.04183733774539901 2.213229901459104 4.718051079905393e-06 0.1442313683705848 0.23635856579458786 1784.5807262379376 5.564703378225056 271.9234395492443 77.43289386420064 3.1405625314753547e-15 14.502992554973066 -2.213225183408024 (ac)SNRPNNNPGGS(ph)LRR ddPTM_A459_Selumetinib_30min_R2 1 SNRPNNNPGGSLRR 14 2 Q14669;Q14669-2;Q14669-3;Q14669-4;G5E9G6;F8W9P3;C9JLJ5;C9JSX9;C9JLD7 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 SNRPNNNPGGS(1)LRR 61.82100000000001 0.04322 1025400.0 885.64 750.4 895.37 1891.1 2727.1 2454.1 909.05 2109.8 3500.5 3518.2 True False 836.4196742978215 807.9532670837015 837.7628690051464 1633.5289176705394 2384.4973174166726 2792.129998898261 951.3226262484022 2115.9391687038074 4200.697812142025 3416.6204246186157 0.24480907164019775 0.23647732749648073 0.24520220711923615 0.4781124955819123 0.6979110995869098 0.8172198406294828 0.27843965908346247 0.619307650758425 1.2294891706066333 1.0 11.73835426262003 -6.601210438016931 0.2883078006061571 1.0782398773887936 3.79483901126816e-15 0.6043548837411633 0.2098936889015669 2.246746678557664 0.3635877726789526 0.3266674353547079 0.8354008673447363 2.5048952083400984e-07 6.601210438016931 -1.0782398773887898 (ac)SQGDS(ph)NPAAIPHAAEDIQGDDR ddPTM_A459_Selumetinib_30min_R1 1 SQGDSNPAAIPHAAEDIQGDDR 22 0 P68402-3;P68402-2;P68402-4;P68402 P68402-3 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 1 S(0.38)QGDS(0.62)NPAAIPHAAEDIQGDDR 90.561 1.0942e-11 10598000.0 362.86 382.18 336.92 303.13 277.6 282.76 241.75 269.45 167.27 247.94 True False 371.313931997349 337.4341879293382 291.16811456908613 250.19403595483166 252.4911290142607 279.9156911255383 223.5146028659584 262.3033107030495 283.8449730825667 279.7655141401174 1.3272326760451993 1.2061321745336278 1.0407577054806616 0.8942990587093048 0.902509838606496 1.0005367959159743 0.7989355069474848 0.937582716401843 1.014581707666822 1.0 8.128074326525663 -5.228837750235366 1.8143460787657495 0.9281277234132371 1.3308292385008682 0.8199062883120317 0.06221732082335135 0.16587641710053255 0.9345025959465643 0.0177689887663709 0.08328431123231202 5.904216168819256e-06 5.228837750235366 0.4027015150876311 (ac)SQPGQKPAAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 SQPGQKPAASPR 12 1 P20810-6;P20810-7;P20810-10;P20810-9;P20810-5;F8W7E0;E9PSG1 P20810-6;P20810-5 CAST Calpastatin 1 SQPGQKPAAS(1)PR;SQPGQKPAAS(1)PR;SQPGQKPAAS(1)PR;SQPGQKPAAS(1)PR 125.36 0.00053641 279162000.0 12134.1 16020.1 11031.3 10756.5 12541.0 11032.5 14410.1 12094.5 6817.9 11826.4 True False 12416.800921151498 14144.459244457572 9533.310050593496 8878.079199512249 11406.668764293376 10921.523066708527 13323.134555361927 11773.714571527298 11569.478340285956 13344.433638891196 0.9304854186515498 1.0599520089960783 0.7144034965117957 0.6653020607512226 0.8547885262848194 0.8184328658863943 0.998403897527191 0.8822940628378433 0.8669890872376714 1.0 13.703950455827226 -7.237811814654071 24.50893199614554 0.9271129480738006 0.8374790504258647 0.15441166632578662 0.10936993370376424 1417.235852504847 1470103.9223175664 0.04601308971312137 0.035618714345261177 5.783465980861343e-08 7.237811814654071 -0.08963389764793595 (ac)SQPGQKPAAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SQPGQKPAASPR 12 1 P20810-6;P20810-7;P20810-10;P20810-9;P20810-5;F8W7E0;E9PSG1 P20810-6;P20810-5 CAST Calpastatin 1 S(0.021)QPGQKPAAS(0.979)PR;SQPGQKPAAS(1)PR;SQPGQKPAAS(1)PR;SQPGQKPAAS(1)PR 97.957 0.0056089 459952000.0 135065.0 120625.0 125657.0 134618.0 139708.0 102397.0 133709.0 141016.0 106123.0 104924.0 True False 127558.62800803404 129876.54962949314 117572.36542499735 116282.79617099733 122156.63203463331 116501.25728258221 139926.73343935705 141426.33321354454 127350.56532436759 101894.57149470862 1.2518687319339494 1.2746169665793983 1.153862896720684 1.1412069795792397 1.1988531895536445 1.1433509712402306 1.3732501289003745 1.387967299326528 1.2498267911257754 1.0 16.636717667390208 -7.246025532564563 24.828873234813024 1.2850916730861885 1.1936281498221104 0.03378875827587269 0.10849502067021553 1463.8313985290247 2357964.3773615584 0.0404060124765893 0.031181245209487226 5.6751123992976194e-08 7.246025532564563 -0.09146352326407814 (ac)SQPGQKPAAS(ph)PRPR ddPTM_A459_Selumetinib_30min_R1 4 SQPGQKPAASPRPR 14 2 P20810-6;P20810-7;P20810-10;P20810-9;P20810-5;F8W7E0;E9PSG1 P20810-6;P20810-5 CAST Calpastatin 1 SQPGQKPAAS(1)PRPR;S(0.001)QPGQKPAAS(0.999)PRPR;SQPGQKPAAS(1)PRPR;SQPGQKPAAS(1)PRPR 97.631 0.00097058 2042623200.0 9439.3 9927.82 11352.0 12084.3 10106.1 8760.74 10339.199999999999 8850.349999999999 5595.419999999999 7995.639999999999 True False 9659.217324319497 8765.4662190817 9810.460752072508 9974.003855405188 9192.005039376867 8672.614909715481 9559.305819862328 8615.60996801163 9495.019066692501 9021.958278128932 1.070634226688391 0.9715702454899374 1.0873981512256676 1.1055253801809535 1.0188480988279633 0.9612785431229126 1.0595599674891023 0.9549600765609421 1.052434379984927 1.0 13.139224899019545 -6.506550975215838 24.80763285983219 1.0044080875070263 1.0555453717473564 0.23601522172460998 0.04523830835973162 1010.3176574691996 1535031.3071957855 0.014076788678604225 0.015528477425054116 3.1149352596997265e-07 6.506550975215838 0.05113728424033015 (ac)SQPGQKPAAS(ph)PRPR ddPTM_A459_Selumetinib_30min_R2 6 SQPGQKPAASPRPR 14 2 P20810-6;P20810-7;P20810-10;P20810-9;P20810-5;F8W7E0;E9PSG1 P20810-6;P20810-5 CAST Calpastatin 1 SQPGQKPAAS(1)PRPR;SQPGQKPAAS(1)PRPR;S(0.001)QPGQKPAAS(0.999)PRPR;SQPGQKPAAS(1)PRPR;S(0.008)QPGQKPAAS(0.992)PRPR;SQPGQKPAAS(1)PRPR 86.49799999999998 0.0053498 4648518800.0 404055.5 368074.0 375546.6 391934.8 398641.1 287544.19999999995 308916.9 313658.1 251211.09999999998 304135.4 True False 381599.7128723223 396304.09225555195 351384.34062022105 338552.60411475797 348560.24112134933 327150.80348363984 323282.1479572244 314570.79314210627 301460.3394245946 295354.2207633314 1.2920069734777881 1.3417925473735217 1.189704821932397 1.1462595768558244 1.1801430845325624 1.1076557586958853 1.094557399998261 1.0650627992689943 1.0206738831951756 1.0 18.172086703396985 -4.275985024823541 0.24979013303617492 0.9843117074060392 1.7215172970075272 0.9078561320554199 0.03189027270625014 3.55064098763092 0.15435910575115067 0.04580047333110566 0.8408702718822942 5.296817078591246e-05 4.275985024823541 0.737205589601488 (ac)SQSGAVSCCPGATNGS(ph)LGR ddPTM_A459_Selumetinib_30min_R1 2 SQSGAVSCCPGATNGSLGR 19 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3;E9PNY4;E9PM34;E9PN68;E9PLN2;E9PNT0;E9PLH1 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 1 SQSGAVSCCPGAT(0.062)NGS(0.938)LGR;SQSGAVSCCPGAT(0.259)NGS(0.74)LGR 131.9 1.9516e-16 11491000.0 429.921 357.87 302.97 452.22 480.96 376.52 467.46 173.5 343.162 195.44 True False 439.93732281935786 315.97041403075065 261.8283380950851 373.24826622074374 437.457252920385 372.7325506528072 432.19911584579484 168.89821639257397 582.3208504391688 220.52662774681173 1.9949396919289637 1.4327993732961746 1.1872867270962497 1.6925315098423075 1.9836935674844351 1.690192946135939 1.9598500202071103 0.7658858166846286 2.6405920064570876 1.0 7.7848090559834 -11.124663325157329 5.896932361610235 0.9969983745202229 1.669281027592303 0.15717625879698838 0.4835418334450162 0.01794126302250758 0.001211557457641036 0.4402015718601725 0.10646517760041171 7.504757695667506e-12 11.124663325157329 0.67228265307208 (ac)SQSGAVSCCPGATNGS(ph)LGR ddPTM_A459_Selumetinib_30min_R2 2 SQSGAVSCCPGATNGSLGR 19 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3;E9PNY4;E9PM34;E9PN68;E9PLN2;E9PNT0;E9PLH1 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 1 SQSGAVSCCPGAT(0.1)NGS(0.9)LGR;SQSGAVSCCPGAT(0.012)NGS(0.988)LGR 181.94 3.7862e-48 11717000.0 0.0 0.0 897.43 3193.5 1983.9 830.72 1304.8 807.93 0.0 2096.1 True False 0.0 0.0 839.6903308479048 2758.5397909052253 1734.6647457089698 945.1441394746599 1365.4757854121501 810.2809425399885 0.0 2035.580146678155 0.0 0.0 0.41250664200974246 1.355161473453581 0.8521721674971893 0.4643119265124649 0.6708042361488237 0.39805897294797193 0.0 1.0 10.99122431033495 -5.396569058078785 4.257366943859257 0.6639086699672307 0.006542338552937919 0.3735405689215223 0.34513764660332763 0.2529221345295393 7.456710959211313 0.09837771073711399 0.21665734029013456 4.012646872478309e-06 5.396569058078785 -0.6573663314142928 (ac)SRHEGVS(ph)CDACLK ddPTM_A459_Selumetinib_30min_R2 1 SRHEGVSCDACLK 13 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 S(0.026)RHEGVS(0.974)CDACLK 59.185 0.014999 8678200.0 55761.0 57941.0 78067.0 80035.0 77009.0 53374.0 44990.0 52320.0 38770.0 65991.0 True False 52662.02684896892 62384.88839032084 73044.25421292274 69134.0949319241 67334.44095080512 60725.78401906838 47082.124145993774 52472.242537957725 46525.08332430975 64085.66836479076 0.8217442088487589 0.973460837378044 1.1397907843784603 1.0787762177714446 1.0506942139937057 0.947571985570984 0.7346747774867729 0.8187827930462288 0.7259826496538663 1.0 15.967714139033026 -7.06483360428349 4.519835768548656 0.8060158396869326 1.020211317473998 0.42698276383408507 0.10479925279159667 0.2001049249092731 8.041028375270525 0.041481172630346376 0.032475974087172496 8.613236967894893e-08 7.06483360428349 0.21419547778706538 (ac)SS(ph)PASTPSR ddPTM_A459_Selumetinib_30min_R2 1 SSPASTPSR 9 0 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IS57;E5RFR3;E5RG53;A0A3B3IS88 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 S(0.194)S(0.767)PAS(0.039)T(0.001)PSR 110.41 0.0028435 68789000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)SS(ph)PASTPSRR ddPTM_A459_Selumetinib_30min_R2 1 SSPASTPSRR 10 1 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IS57;E5RFR3;E5RG53;A0A3B3IS88 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 S(0.223)S(0.777)PASTPSRR 75.043 0.013900999999999998 37292000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)SS(ph)SPLSK ddPTM_A459_Selumetinib_30min_R1 1 SSSPLSK 7 0 P22314;Q5JRR9 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 S(0.032)S(0.741)S(0.222)PLS(0.005)K 65.24600000000001 0.0090972 661850000.0 19875.0 22741.0 29252.0 32501.0 29367.0 27324.0 27990.0 27185.0 16610.0 23744.0 True False 20338.048829982097 20078.47314799592 25279.73906973438 26825.31046932997 26710.760035164963 27049.145368207002 25878.691765121715 26463.96549067506 28185.956853598567 26791.7736861456 0.7591154310361761 0.7494267973149825 0.9435634745902204 1.001251756736125 0.9969761744060069 1.0096063696669135 0.9659193179324275 0.9877645952331982 1.0520377330663224 1.0 14.709502474111671 -5.344596380066715 3.076377439305461 0.9992533279339662 0.748106343497036 0.9535978420189544 0.021494554314759197 0.04730107670277001 0.8575451106375332 0.005974191308537952 0.01532363812193718 4.522760805918646e-06 5.344596380066715 -0.2511469844369302 (ac)SS(ph)SPLSK ddPTM_A459_Selumetinib_30min_R2 2 SSSPLSK 7 0 P22314;Q5JRR9 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 S(0.276)S(0.587)S(0.132)PLS(0.005)K;S(0.041)S(0.627)S(0.329)PLS(0.003)K 69.423 0.015842 866903700.0 81720.0 85764.0 92294.0 104862.0 107784.0 82150.0 94904.0 92743.0 74712.0 90908.0 True False 77178.32955107934 92341.8230252755 86355.90452210917 90579.61470296017 94243.21031881437 93465.4168165488 99317.22404870832 93012.86677556974 89656.48762769728 88283.24983264983 0.8742126020210965 1.0459721770587187 0.9781686184616657 1.0260113314208905 1.0675095275430193 1.0586993228468855 1.1249837793349762 1.053573208415927 1.015554907614418 1.0 16.42985211781164 -3.725372404570678 0.9313689591857953 1.0536069232868897 1.1960819342911118e-22 0.5843091933596078 0.040694411507052726 9.029287584746912 1.3844361801637082 0.013661468932782209 15.231607895727398 0.0001882034565500489 3.725372404570678 -1.0536069232868897 (ac)SSAPT(ph)TPPSVDKVDGFSR ddPTM_A459_Selumetinib_30min_R2 1 SSAPTTPPSVDKVDGFSR 18 1 Q16537-2;Q16537 Q16537-2 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1 S(0.106)S(0.106)APT(0.393)T(0.393)PPS(0.001)VDKVDGFSR 64.827 0.013654 4393400.0 18113.0 20086.0 25519.0 27358.0 25569.0 16498.0 18285.0 16494.0 13652.0 19874.0 True False 17106.351972083972 21626.531613330542 23877.1353229864 23631.793204817623 22356.793630239757 18770.449746067203 19135.288731040135 16541.994809271317 16382.781468751 19300.185981146722 0.8863309394424601 1.1205348816045761 1.2371453490816433 1.2244334447296108 1.1583719271969122 0.9725527911701478 0.9914561833617735 0.8570899174458874 0.8488406010571311 1.0 14.23632712925966 -6.97689679597464 2.238415258745919 0.9093425105564508 1.1367250866168694 0.4640663516015556 0.1020796092875379 0.27758328223825385 2.803191570598761 0.045896244192709865 0.03670323248746499 1.054637486502281e-07 6.97689679597464 0.22738257606041867 (ac)SSAPTT(ph)PPSVDKVDGFSR ddPTM_A459_Selumetinib_30min_R1 1 SSAPTTPPSVDKVDGFSR 18 1 Q16537-2;Q16537 Q16537-2 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1 S(0.268)S(0.268)APT(0.087)T(0.371)PPS(0.005)VDKVDGFSR 87.669 0.027412 0.0 1637.1 1865.3 2364.1 2363.9 2123.2 1519.4 1986.2 1862.3 1106.4 1568.3 True False 1675.241244757922 1646.9098088455562 2043.0682050717587 1951.0892408987136 1931.156934881406 1504.11621550482 1836.3793349012062 1812.905754397064 1877.4799917412067 1769.6065815356365 0.946674397709447 0.9306643781898652 1.1545324403680826 1.1025553709263385 1.0912916775013228 0.8499720961704222 1.0377331063651591 1.0244682480915352 1.0609589788663418 1.0 10.789212941040816 (ac)SSAPTT(ph)PPSVDKVDGFSR ddPTM_A459_Selumetinib_30min_R2 1 SSAPTTPPSVDKVDGFSR 18 1 Q16537-2;Q16537 Q16537-2 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1 S(0.02)S(0.02)APT(0.268)T(0.662)PPS(0.026)VDKVDGFS(0.004)R 42.149 0.045853 18265000.0 16620.0 19271.0 28093.0 21466.0 24243.0 17507.0 18430.0 17090.0 12560.0 18723.0 True False 15696.326935131425 20749.023733968577 26285.526965345685 18542.293769084557 21197.37760483017 19918.43033727715 19287.031518352185 17139.729070598198 15072.350955721708 18182.418341803866 0.8632694859431005 1.1411586370919502 1.4456562637166732 1.019792495173939 1.1658172860369458 1.0954775081531347 1.0607517193688512 0.9426539830068488 0.8289519398565542 1.0 14.150256476644495 -7.627018642729092 1.9813786417080723 0.9047173191486169 1.1360707649433666 0.27829839413889135 0.14182672832212087 0.43055506052860776 3.3452037594093933 0.09388656806536545 0.04362005407031431 2.360376908357054e-08 7.627018642729092 0.2313534457947497 (ac)SSDASQGVITT(ph)PPPPSMPHK ddPTM_A459_Selumetinib_30min_R1 2 SSDASQGVITTPPPPSMPHK 20 0 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 S(0.003)S(0.003)DAS(0.009)QGVIT(0.034)T(0.951)PPPPS(0.001)MPHK;SSDASQGVIT(0.014)T(0.985)PPPPSMPHK 83.792 6.2477e-08 24420000.0 3176.9 3942.4 3594.2000000000003 3896.7 4238.6 3310.3 4450.0 4247.0 2193.5 2925.5 True False 3250.9155888286864 3480.8219752279624 3106.127381527395 3216.214495118244 3855.219378385609 3277.0013875119175 4114.332917284445 4134.355763799781 3722.2092930986423 3301.016421783143 0.9848226041458488 1.0544697543030375 0.9409608995066819 0.9743103590441726 1.1678885790889513 0.9927249576485739 1.2463836562987969 1.2524493172822464 1.1275949033564576 1.0 11.688694600310138 -6.587871594305939 1.3342631100437752 1.163320546600686 0.991492717406182 0.3321085311811809 0.09000868723075343 0.44360412932832544 1.6448557470793057 0.039373038954497896 0.04152430072546612 2.583023787568298e-07 6.587871594305939 -0.171827829194504 (ac)SSDASQGVITT(ph)PPPPSMPHK ddPTM_A459_Selumetinib_30min_R2 1 SSDASQGVITTPPPPSMPHK 20 0 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 S(0.005)S(0.005)DAS(0.006)QGVIT(0.017)T(0.965)PPPPS(0.002)MPHK 80.459 0.00076625 14699000.0 46016.0 40002.0 39247.0 44457.0 47781.0 35202.0 31819.0 37586.0 33306.0 44577.0 True False 43458.61493664305 43070.0247732972 36721.89074890267 38401.8799073974 41778.32361244032 40050.755968060206 33298.64654815237 37695.36903730271 39968.13064739388 43289.94618504463 1.0038962569017165 0.9949198039931173 0.8482775790926941 0.8870854157047691 0.9650814402461296 0.9251745381447606 0.7692004606754639 0.8707649779967923 0.9232658889560289 1.0 15.40174438664586 -7.02682396258899 24.843631307792567 0.875345283484823 0.9359160330568675 0.08299332348839228 0.06938385257776263 1410.8775991482398 1306712.6171153013 0.02702038311065451 0.02099468740853304 9.401042962716992e-08 7.02682396258899 0.06057074957204456 (ac)SSILPFT(ph)PPVVKR ddPTM_A459_Selumetinib_30min_R1 1 SSILPFTPPVVKR 13 1 K7ESI8;K7EL92;K7ERC7;K7EJX0;B7Z5N5;Q15796-2;Q15796 K7ESI8 SMAD2 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 2 1 SSILPFT(1)PPVVKR 89.663 0.010318 50094000.0 1154.4 988.0 3739.5 3382.6 2285.2 1651.1 1297.9 1501.4 1060.7 783.43 True False 1181.2952739286213 872.3245006912613 3231.6964396031644 2791.8924092660377 2078.5040634848297 1634.4914330788538 1199.998358054715 1461.5779947654794 1799.9304295371455 883.9908717544246 1.3363206699002983 0.9868026113889508 3.6558029532469423 3.1582819443882606 2.3512732200047477 1.8489913021781978 1.357478223358938 1.653385845336546 2.0361414207421498 1.0 9.787887661945032 -6.901619173726458 3.7186775897319904 1.56898519631606 2.3471029088620887 0.1878088666153267 0.7643320621362439 0.45775651812018614 12.17705183508647 0.3132370969574974 0.27253007704131543 1.2542405174438663e-07 6.901619173726458 0.7781177125460288 (ac)SSPKRSSKPSMSLAPS(ph)GSS(ph)MPT(ph)ADPK ddPTM_A459_Selumetinib_30min_R1 1 SSPKRSSKPSMSLAPSGSSMPTADPK 26 3 B3KS81 B3KS81 SRRM5 Serine/arginine repetitive matrix protein 5 3 S(0.022)S(0.022)PKRS(0.036)S(0.036)KPS(0.108)MS(0.108)LAPS(0.494)GS(0.48)S(0.847)MPT(0.847)ADPK 42.041 0.0062153 3534400.0 114.59 269.89 172.15 315.98 277.6 221.89 177.34 171.07 62.697 210.05 True False 117.25972404667421 238.29115333154286 148.7729755522623 260.8000246792063 252.4911290142607 219.65798806000043 163.96310102274686 166.53266788632646 106.39222979229795 237.0119635602631 0.4947417939806213 1.0053971527515508 0.6277023881726334 1.1003664994864057 1.0653096376295867 0.9267801707577086 0.6917925093728752 0.7026340163794456 0.4488897024189518 1.0 7.888816073090024 -10.567128146784453 4.672301626348689 1.0000060618633644 0.8032595290570607 0.07343178560253316 0.2207241821916857 52388214.67155512 118483995.66094701 2039.883292400776 0.054782803025315546 2.7093920566640502e-11 10.567128146784453 -0.19674653280630372 (ac)SSS(ph)PLSK ddPTM_A459_Selumetinib_30min_R1 1 SSSPLSK 7 0 P22314;Q5JRR9 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 S(0.038)S(0.281)S(0.632)PLS(0.049)K 54.722 0.020982 576470000.0 11244.0 12668.0 16837.0 17706.0 16928.0 16189.0 16469.0 16295.0 9880.7 14828.0 True False 11505.963322984591 11184.824670806576 14550.627879020858 14613.97948278379 15396.865388881144 16026.153358435922 15226.730070732032 15862.803666380363 16766.826242224644 16731.318236951105 0.6876901843617844 0.6684963200392005 0.8696641635137754 0.8734505719046588 0.9202422170703308 0.9578535971566289 0.9100735432252917 0.9480904876549041 1.002122247916791 1.0 14.030263497310024 -5.293495433150208 0.8539743576506116 0.9600090746244043 0.5918563423042439 0.8974865204673095 0.035690759447984007 0.36080091790756613 0.33670066472558646 0.013854353239961334 0.10838727330788615 5.087501694096229e-06 5.293495433150208 -0.36815273232016044 (ac)SSSGT(ph)PDLPVLLTDLK ddPTM_A459_Selumetinib_30min_R1 2 SSSGTPDLPVLLTDLK 16 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 S(0.122)S(0.122)S(0.236)GT(0.519)PDLPVLLTDLK;S(0.137)S(0.137)S(0.137)GT(0.589)PDLPVLLTDLK 146.59 3.582e-15 49546000.0 12440.2 16292.8 12849.099999999999 15065.099999999999 11092.1 11901.7 12116.400000000001 10173.099999999999 7006.799999999999 8678.9 True False 12730.032455584582 14385.231401682777 11104.262795054156 12434.26309195109 10088.821513469306 11781.979703878987 11202.450193030394 9903.276341114093 11890.027843575826 9792.921354644923 1.2999218511590054 1.4689417877189073 1.1339070735809846 1.2697194883581233 1.0302157188961834 1.203111847547987 1.1439334379742478 1.0112688525183373 1.2141451373890813 1.0 13.257523583220177 -5.5104384445446914 1.3958364925304783 1.1129748550893714 1.3912623522159595 0.49871345640621834 0.09868823866767194 0.3866524072022905 1.3810716154520652 0.02940075772126046 0.1028618182614824 3.0871771809007425e-06 5.5104384445446914 0.27828749712658807 (ac)SSSGT(ph)PDLPVLLTDLK ddPTM_A459_Selumetinib_30min_R2 2 SSSGTPDLPVLLTDLK 16 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 S(0.163)S(0.163)S(0.163)GT(0.51)PDLPVLLTDLK;S(0.135)S(0.135)S(0.135)GT(0.595)PDLPVLLTDLK 99.927 1.1169e-06 45616000.0 334250.0 345270.0 393070.0 393980.0 400040.0 264440.0 274540.0 284730.0 226650.0 355800.0 True False 315673.7231087654 371751.0987819693 367780.30414225755 340319.2443465917 349783.39879702445 300864.20965268597 287306.65399068984 285558.5171604111 271986.33313012094 345527.1295205794 0.9136003981706565 1.0758955434202107 1.0644035524867599 0.9849277097829809 1.0123181912874704 0.8707397594803526 0.8315024478376828 0.8264431147754591 0.7871634667515205 1.0 18.398439464611016 -6.792281200738012 4.090600075985488 0.8473136263221118 1.0168080074230912 0.5406470249039456 0.06716390557790654 0.14782805963103915 5.396216734637309 0.023223066863641017 0.02121214805399089 1.6133136163503017e-07 6.792281200738012 0.16949438110097936 (ac)SSSPVNVKK ddPTM_A459_Selumetinib_30min_R2 2 SSSPVNVKK 9 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 ; 44.447 0.028717000000000006 0.0 81736.0 81217.0 89693.0 92998.0 97458.0 67093.0 59711.0 64395.0 51727.0 76622.0 False True 77193.44033513243 87446.08274618456 83922.25003035477 80331.51196950197 85214.45475442562 76334.4517403859 62487.67981510188 64582.37878883388 62073.84537313829 74409.72377213578 1.0374106557836607 1.1751969811629714 1.1278398275922796 1.0795835261464002 1.1452059009838158 1.0258666189131975 0.8397784139940814 0.8679292908895067 0.834216849980877 1.0 16.183203542834228 -7.071971109728566 3.5335970643593524 0.8753382645164142 1.1145527547593512 0.7856239511066944 0.055821125733585136 0.09980223588755313 2.4111264593658848 0.021215143082295364 0.016516695430879143 8.472837755384949e-08 7.071971109728566 0.23921449024293706 (ac)STGPTAAT(ph)GSNRR ddPTM_A459_Selumetinib_30min_R2 2 STGPTAATGSNRR 13 1 Q15836 Q15836 VAMP3 Vesicle-associated membrane protein 3 1 STGPTAAT(0.5)GS(0.5)NRR;STGPTAAT(0.684)GS(0.316)NRR 115.24 0.00067774 16249800.0 595.88 545.58 882.0 1841.44 2020.0100000000002 1851.5500000000002 397.14 2233.3 1746.2400000000002 817.11 True False 562.7633750966372 587.4242316838032 825.2530802489913 1590.632695338819 1766.238284681475 2106.584205802564 415.60779691798103 2239.7985332572835 2095.5367940222513 793.5179111932575 0.7092005954224502 0.7402784781511237 1.0399930091155873 2.004532818858361 2.225832914124753 2.65474058756251 0.5237535171613307 2.8226187483142913 2.640818517720759 1.0 9.632118977546025 -5.690515792768912 3.402571302018668 2.042580430127656 0.7527060342328538 0.3713442336364089 0.6910951964242084 0.2436385479294224 5.61611688520285 0.19451896059507293 0.35173031950653905 2.0393145002315765e-06 5.690515792768912 -1.2898743958948025 (ac)STNENANT(ph)PAAR ddPTM_A459_Selumetinib_30min_R1 1 STNENANTPAAR 12 0 P52292;J3QLL0;J3KS65;J3QL07 P52292 KPNA2 Importin subunit alpha-1 1 STNENANT(1)PAAR 132.79 0.022272 379730.0 0.0 0.0 65.337 64.819 58.234 0.0 125.92 0.0 58.512 0.0 True False 0.0 0.0 56.46459427045111 53.49957845332446 52.96674498204775 0.0 116.4217530212264 0.0 99.2905904526044 0.0 0.0 (ac)STNENANT(ph)PAAR ddPTM_A459_Selumetinib_30min_R2 2 STNENANTPAAR 12 0 P52292;J3QLL0;J3KS65;J3QL07 P52292 KPNA2 Importin subunit alpha-1 1 STNENANT(1)PAAR;STNENANT(1)PAAR 199.4 8.907200000000001e-17 24958000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)STSS(ph)LRR ddPTM_A459_Selumetinib_30min_R2 1 STSSLRR 7 1 Q9Y6I3-3;Q9Y6I3 Q9Y6I3-3 EPN1 Epsin-1 1 STS(0.02)S(0.98)LRR 57.177 0.04602 3940300.0 0.0 3408.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 3669.813320266643 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 (ac)STVHEILCKLSLEGDHS(ph)TPPSAYGSVK ddPTM_A459_Selumetinib_30min_R2 1 STVHEILCKLSLEGDHSTPPSAYGSVK 27 1 P07355;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 S(0.007)T(0.007)VHEILCKLS(0.013)LEGDHS(0.767)T(0.205)PPSAY(0.001)GSVK 49.618 8.7013e-08 165680000.0 51999.0 42294.0 66464.0 85384.0 74153.0 41673.0 38516.0 40964.0 30102.0 68847.0 True False 49109.103748489695 45537.81380335566 62187.77860053164 73754.5519043843 64837.23720376896 47413.07748017083 40307.07031800611 41083.19845804473 36123.24112015403 66859.20822401179 0.7345151857609447 0.6811001059237974 0.9301303478224192 1.1031322964111339 0.9697577779642825 0.7091480551386925 0.6028649065504524 0.6144733021724617 0.5402881978369098 1.0 16.028838649580216 -6.894273026992856 5.628637643313786 0.6572793433009243 0.886341505636905 0.25136365015489237 0.16041700458795743 0.2745523155258667 12.709612346766699 0.06006521217769792 0.05291451174602178 1.275636604913025e-07 6.894273026992856 0.22906216233598065 (ac)SVCTLSVPVSSLS(ph)PGRR ddPTM_A459_Selumetinib_30min_R2 4 SVCTLSVPVSSLSPGRR 17 1 P86452 P86452 ZBED6 Zinc finger BED domain-containing protein 6 1 SVCTLSVPVS(0.057)S(0.069)LS(0.874)PGRR;SVCTLSVPVS(0.071)S(0.071)LS(0.858)PGRR;SVCTLSVPVS(0.185)S(0.185)LS(0.63)PGRR;SVCTLSVPVS(0.176)S(0.176)LS(0.649)PGRR 98.421 1.6267000000000002e-05 4958600.0 6116.389999999999 6193.0599999999995 8427.98 6920.099999999999 9484.9 3999.43 5481.93 7164.76 6604.67 7029.070000000001 True False 5776.465529649131 6668.04778817349 7885.732942490805 5977.57044216165 8293.32206591815 4550.3151792892195 5736.850607238217 7185.608265410129 7925.788549898602 6826.12248538286 0.8462293991967745 0.9768426808121501 1.1552287494660323 0.8756904750774309 1.2149389472100864 0.6666032127365209 0.8404259694318175 1.0526632478097273 1.1610967378435584 1.0 12.73685058651009 -7.977903196224825 20.840148942416313 1.0893256028858174 0.9467951031691793 0.13468829894124645 0.15309145603770555 66.9253235429804 63118.41283757424 0.08481995640053681 0.04072990415231327 1.0521963811336876e-08 7.977903196224825 -0.14253049971663811 (ac)SVPAFIDISEEDQAAELR ddPTM_A459_Selumetinib_30min_R1 1 SVPAFIDISEEDQAAELR 18 0 E9PRI2;E7ESM3;Q7L2H7 E9PRI2 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 119.88 0.00019328 1292600.0 0.0 0.0 0.0 0.0 117.78 0.0 67.001 73.118 0.0 0.0 False True 0.0 0.0 0.0 0.0 107.12681979574793 0.0 61.947060627185415 71.17867311926354 0.0 0.0 0.0 (ac)TECFLPPT(ph)SSPSEHRR ddPTM_A459_Selumetinib_30min_R2 1 TECFLPPTSSPSEHRR 16 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 TECFLPPT(0.525)S(0.276)S(0.187)PS(0.013)EHRR 61.657 0.013432 8517900.0 6932.0 2937.8 2591.2 4577.5 5649.4 964.34 5988.2 2899.3 2674.7 1233.7 True False 6546.74719099465 3163.119813484139 2424.4850130852437 3954.0366033720547 4939.6718657232 1097.1690815930688 6266.663165393195 2907.7364829950475 3209.714737362168 1198.0798754624489 5.464366212200718 2.640157704229195 2.0236422151314515 3.300311343470175 4.122990434019709 0.9157728996737974 5.230588789394627 2.42699718319923 2.679049037630521 1.0 10.226508379843972 (ac)TECFLPPTS(ph)SPSEHRR ddPTM_A459_Selumetinib_30min_R1 1 TECFLPPTSSPSEHRR 16 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 TECFLPPT(0.035)S(0.482)S(0.482)PS(0.001)EHRR 86.22200000000002 0.0069735 4955500.0 669.15 519.06 931.84 669.12 751.24 577.15 679.36 416.23 434.88 574.23 True False 684.7398930607557 458.28821389555264 805.3012462307291 552.2707529380041 683.2904746421942 571.3443950102717 628.115328244126 405.19022829441536 737.9595976214902 647.9380139738631 1.0567984564776238 0.7073025567443236 1.2428677263303984 0.8523512142016132 1.0545614856759387 0.8817886629404011 0.9694065091070011 0.6253533818911884 1.1389354872011852 1.0 9.339711991758142 -6.80162400933464 24.976460787177903 0.9025757164147065 0.9746761457455664 0.019903924075296286 0.1784972370463163 614.3456331776791 381837.879198047 0.05933054897461016 0.05232528908822092 1.5789776788460863e-07 6.80162400933464 0.07210042933085992 (ac)TECFLPPTSS(ph)PSEHR ddPTM_A459_Selumetinib_30min_R1 1 TECFLPPTSSPSEHR 15 0 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 TECFLPPT(0.001)S(0.228)S(0.77)PS(0.001)EHR 150.9 6.1653e-05 10624000.0 147.62 234.49 143.87 179.14 204.6 88.57600000000002 186.78 146.66 0.0 128.18 True False 151.05925878148219 207.03580178855654 124.33324422134172 147.85656187427364 186.0939661250639 87.68500586057326 172.69103422255932 142.77010038118104 0.0 144.63315157893132 1.0444303891078797 1.4314546805375388 0.8596455436669979 1.0222868011942836 1.2866619035367282 0.6062580044985089 1.1939934402128813 0.9871187817079852 0.0 1.0 7.176254462235148 -8.035667585452737 22.93837793653301 0.4978519071612653 1.0614861479575328 0.3418921541554215 0.3090223336501357 231.94223703295313 149162.7946301659 0.1940198131344962 0.07343668714869511 9.211543653144525e-09 8.035667585452737 0.5636342407962676 (ac)TECFLPPTSS(ph)PSEHR ddPTM_A459_Selumetinib_30min_R2 4 TECFLPPTSSPSEHR 15 0 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 TECFLPPT(0.011)S(0.188)S(0.612)PS(0.188)EHR;TECFLPPT(0.012)S(0.213)S(0.663)PS(0.112)EHR;TECFLPPTS(0.025)S(0.744)PS(0.231)EHR;TECFLPPT(0.003)S(0.369)S(0.548)PS(0.08)EHR 115.09 0.00020849 42942200.0 2054.0 1794.22 3485.8999999999996 4166.4 2821.26 2816.1 1341.1 882.54 1710.75 1154.2 True False 1939.8469028134743 1931.8309046733991 3261.6209891609474 3598.929132559112 2466.8280964155906 3203.992212989444 1403.4638073392348 885.1080452876381 2052.947802348799 1120.8752470282552 1.730653708302093 1.7235021558333166 2.909887605965419 3.210820421006576 2.200805221594305 2.858473520121082 1.2521141947421879 0.7896579459973802 1.8315578007380584 1.0 10.130410000352992 -7.275822477647406 23.15666911204602 1.200803529933532 2.4521564740415704 0.5719543242003697 0.5171759642697924 238.3057704375559 383667.30525093904 0.22908940359776583 0.15544907771048522 5.298799935473737e-08 7.275822477647406 1.2513529441080384 (ac)TECFLPPTSS(ph)PSEHRR ddPTM_A459_Selumetinib_30min_R1 2 TECFLPPTSSPSEHRR 16 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 TECFLPPT(0.135)S(0.05)S(0.581)PS(0.234)EHRR;TECFLPPT(0.008)S(0.008)S(0.782)PS(0.203)EHRR 97.452 5.5531e-05 11920000.0 475.02000000000004 608.21 364.21000000000004 636.22 442.72 413.16999999999996 591.55 476.46 436.40999999999997 270.82 True False 486.0870417719799 537.0004904508419 314.75228246232626 525.1161203285164 402.67605416856435 409.0138849283444 546.9289072403628 463.822733039803 740.5558958747106 305.5823850101903 1.590690647158115 1.7573018498200883 1.0300079386180265 1.7184109624349104 1.3177332003450928 1.3384733708217669 1.789791997408896 1.5178320341479625 2.4234246874210865 1.0 8.2554175728379 -7.269016865951066 24.280726691509997 1.7259148569980713 1.45824126666481 0.07213750416025744 0.38118107585177685 951.5906550604996 3049186.7200736287 0.14887453140210952 0.10266967976404032 5.382488790604281e-08 7.269016865951066 -0.26767359033326144 (ac)TEVMMNTQPMEEIGLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 TEVMMNTQPMEEIGLSPR 18 0 B5MBX5 B5MBX5 LBH 1 TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR 314.42 4.015599999999996e-256 67395200.0 0.0 0.0 0.0 306.3 114.47 0.0 0.0 0.0 184.686 50.892 True False 0.0 0.0 0.0 252.8104549631017 104.11620871131996 0.0 0.0 0.0 313.3986530682544 57.424483930059075 0.0 0.0 0.0 4.402485449778105 1.8130978562755513 0.0 0.0 0.0 5.457578921387653 1.0 5.843594081146373 -5.608692469313063 24.999470419963867 1.6628939037849464 1.546337118972523e-05 0.1799964593561013 1.7510789292602231 43.74232946066116 12735.307508047154 0.48965014841469096 0.8480990374031372 2.462110445763106e-06 5.608692469313063 -1.6628784404137567 (ac)TEVMMNTQPMEEIGLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 9 TEVMMNTQPMEEIGLSPR 18 0 B5MBX5 B5MBX5 LBH 1 TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR;TEVMMNTQPMEEIGLS(1)PR 190.8 5.954199999999999e-33 11837900.0 1069.86 735.25 1549.1399999999999 1217.19 1960.07 867.55 1407.1599999999999 1464.78 1435.52 754.58 True False 1010.4014641889111 791.6413107986298 1449.4700189761013 1051.4066222301335 1713.8284833518737 987.0471376652072 1472.595728234642 1469.0422672926165 1722.664111780066 732.7933147657087 1.3788355377013233 1.0803064040666586 1.9780066080973064 1.4347928686635099 2.3387610787631505 1.3469652598847595 2.0095649053587032 2.004715705904473 2.350818541966151 1.0 9.517262531639776 -5.262091541100103 24.999634295084363 1.840202676049781 1.2295709429020754 0.23221703290658458 0.4173928353618875 71.16724528590788 2728219.742873802 0.10157518859017818 0.2339003855154327 5.469006743786909e-06 5.262091541100103 -0.6106317331477056 (ac)VDYS(ph)VWDHIEVSDDEDETHPNIDTASLFR ddPTM_A459_Selumetinib_30min_R1 1 VDYSVWDHIEVSDDEDETHPNIDTASLFR 29 0 Q16543;K7EQA9;K7EKQ2;K7EJ06 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 VDY(0.322)S(0.357)VWDHIEVS(0.322)DDEDETHPNIDTASLFR 57.351000000000006 3.8738e-07 5965200.0 57.71100000000001 115.27 123.46 104.9 128.27 0.0 144.43 0.0 0.0 0.0 True False 59.055554013942015 101.77413481243084 106.69481011723671 86.58118421687678 116.66800114790783 0.0 133.5355288187399 0.0 0.0 0.0 0.0 (ac)VDYSVWDHIEVS(ph)DDEDETHPNIDTASLFR ddPTM_A459_Selumetinib_30min_R1 3 VDYSVWDHIEVSDDEDETHPNIDTASLFR 29 0 Q16543;K7EQA9;K7EKQ2;K7EJ06 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 VDY(0.023)S(0.028)VWDHIEVS(0.949)DDEDETHPNIDTASLFR;VDY(0.105)S(0.117)VWDHIEVS(0.76)DDEDET(0.018)HPNIDTASLFR;VDY(0.274)S(0.294)VWDHIEVS(0.43)DDEDET(0.002)HPNIDTASLFR 84.291 1.0322999999999999e-13 33913000.0 70.498 321.1 341.136 366.67 571.9 73.188 0.0 133.22 67.52199999999999 220.05100000000002 True False 72.14046623477124 283.50546272465976 294.8116049259164 302.6379677483528 520.1717459771457 72.45179516938714 0.0 129.6865728404537 114.579902388241 248.29668932825257 0.290541393966797 1.141801219708816 1.1873360282149001 1.2188562343183729 2.094960457928094 0.29179525254807004 0.0 0.5223048812745376 0.46146367355210427 1.0 7.955921215197838 AAAAAAALQAK ddPTM_A459_Selumetinib_30min_R2 1 AAAAAAALQAK 11 0 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 128.61 0.038005 3144800.0 40386.0 40679.0 54068.0 47036.0 63395.0 40588.0 34098.0 32805.0 47337.0 42989.0 False True 38141.5077979674 43798.94849639911 50589.32374478735 40629.61565837424 55430.753341509226 46178.62857882017 35683.62456390518 32900.4571188399 56805.72270628966 41747.79587116416 0.9136172821117083 1.0491319980476315 1.2117843035572127 0.9732158263818123 1.3277528114914467 1.1061333326753293 0.8547427192090972 0.7880765063710763 1.3606879482115664 1.0 15.349412410197635 AAAAAAGS(ph)GTPR ddPTM_A459_Selumetinib_30min_R2 1 AAAAAAGSGTPR 12 0 Q9NR33 Q9NR33 POLE4 DNA polymerase epsilon subunit 4 1 AAAAAAGS(0.5)GT(0.5)PR 92.943 0.020976 6743400.0 21303.0 13375.0 15032.0 18326.0 19068.0 16416.0 17210.0 21772.0 24534.0 18647.0 True False 20119.064542665743 14400.81949259662 14064.857485604109 15829.967185886688 16672.507369917163 18677.154990389077 18010.299100968048 21835.35291545137 29441.485537235385 18108.612659275586 1.1110218613219034 0.7952469779743307 0.7766943691514553 0.8741678605499504 0.9206949026753398 1.0313962390057678 0.994570895067592 1.2057993246802854 1.6258277810230195 1.0 14.144388402024653 -7.759862344166263 2.5202259524907094 1.3385219158237815 0.9092312629690362 0.47520453152722186 0.1698958817568958 0.22284012541314227 2.831347065072916 0.10616664998830352 0.046792917427366666 1.7383517368262053e-08 7.759862344166263 -0.4292906528547453 AAAAAAGSGT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AAAAAAGSGTPR 12 0 Q9NR33 Q9NR33 POLE4 DNA polymerase epsilon subunit 4 1 AAAAAAGS(0.005)GT(0.995)PR;AAAAAAGS(0.005)GT(0.995)PR 119.74 0.0098266 8937700.0 4091.4 6266.1 4757.200000000001 4487.3 5327.4 4867.3 5965.6 5225.5 2079.0 4166.6 True False 4186.721659521447 5532.462098969142 4111.198369429113 3703.6772920533003 4845.537610628864 4818.339381154807 5515.609989067885 5086.902765183835 3527.9111558477684 4701.423696120884 0.8905220907819656 1.1767631374160006 0.874458171643036 0.7877778161345427 1.030653249701125 1.0248681447558936 1.1731786679041034 1.0819919866786325 0.7503920905402817 1.0 12.198881987901203 AAAAAAGSGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AAAAAAGSGTPR 12 0 Q9NR33 Q9NR33 POLE4 DNA polymerase epsilon subunit 4 1 AAAAAAGS(0.01)GT(0.99)PR 123.26 0.0078149 3798200.0 22468.0 14569.0 21853.0 21189.0 19312.0 19719.0 23534.0 23942.0 25108.0 21925.0 True False 21219.318506530268 15686.395453281513 20447.0017717474 18303.021646936213 16885.85390852949 22435.113258740384 24628.37763173631 24011.667256188524 30130.301576135393 21291.96828200874 0.9965879258076925 0.7367282932943398 0.9603152466192936 0.8596209333263884 0.7930621389661602 1.0536890230903442 1.15669802366495 1.1277335631050076 1.4151017499680787 1.0 14.37802170178859 -7.007234633563577 2.87670271448854 1.1855993722384177 0.8666975222037164 0.5932888991667293 0.11905401451342632 0.17686133478993724 2.966570961762831 0.04585013870094987 0.03679969626992727 9.83479623818358e-08 7.007234633563577 -0.3189018500347013 AAAAAASSSCSSGSCSSGSS(ph)PSLK ddPTM_A459_Selumetinib_30min_R2 1 AAAAAASSSCSSGSCSSGSSPSLK 24 0 A0A3B3IRW6 A0A3B3IRW6 1 AAAAAASSSCSSGS(0.013)CS(0.059)S(0.274)GS(0.151)S(0.479)PS(0.023)LK 100.7 0.00022561 0.0 5616.2 6549.2 5853.6 6082.4 7938.2 4535.0 4646.8 5929.6 5877.9 7003.1 True False 5304.074087429911 7051.5025810029065 5476.98574891779 5253.966627274758 6940.932347591587 5159.655085368815 4862.885407459516 5946.854154301879 7053.6442422481405 6800.9023067610215 0.7799074076033912 1.0368480920528376 0.805332219442841 0.7725396411078572 1.0205899209420133 0.7586721368191712 0.7150353273895945 0.8744213467659868 1.0371630004500814 1.0 12.731510452661958 -8.201954183956744 5.159711591918039 1.0187483135763573 0.8454551538194082 0.3174740688021227 0.10204673295142333 0.24264092442130222 13.328667944965224 0.0759743650510385 0.026568240059360263 6.281246195373412e-09 8.201954183956744 -0.17329315975694914 AAAAAATAPPS(ph)PGPAQPGPR ddPTM_A459_Selumetinib_30min_R1 2 AAAAAATAPPSPGPAQPGPR 20 0 Q6SPF0 Q6SPF0 SAMD1 Atherin 1 AAAAAAT(0.091)APPS(0.909)PGPAQPGPR;AAAAAAT(0.008)APPS(0.992)PGPAQPGPR 171.25 1.5695999999999998e-09 110701000.0 5020.5 5522.5 5984.6 6672.1 6221.4 5303.5 5517.9 4607.9 2651.7 4832.5 True False 5137.467881807558 4875.923132659403 5171.924191054713 5506.942985828631 5658.675468477383 5250.15160519272 5101.680360513222 4485.683523431366 4499.741227494719 5452.798447536166 0.9421708745036983 0.8942056413001248 0.9484898884153026 1.0099296790104042 1.0377562132402385 0.9628361759024833 0.9356077268578309 0.8226387911803729 0.8252168626419552 1.0 12.412781114589468 -10.201515336788809 4.738229767704219 1.0000000237796878 0.9337652850139632 0.08847752003331899 0.06591504413839114 102629987.3407467 261766323.18836576 69.36864408349038 0.018738738654332433 6.287596495434294e-11 10.201515336788809 -0.06623473876572461 AAAAAATAPPS(ph)PGPAQPGPR ddPTM_A459_Selumetinib_30min_R2 2 AAAAAATAPPSPGPAQPGPR 20 0 Q6SPF0 Q6SPF0 SAMD1 Atherin 1 AAAAAAT(0.022)APPS(0.978)PGPAQPGPR;AAAAAAT(0.001)APPS(0.999)PGPAQPGPR 119.8 0.00025307 296350000.0 224388.0 240605.0 273050.0 249272.0 274490.0 179604.0 193094.0 213980.0 192558.0 222125.0 True False 211917.413256334 259058.6298329875 255482.26027436164 215320.72358181558 240006.11222826497 204342.82071721734 202073.2536085023 214602.64637370378 231074.9805200527 215711.6740999406 0.982410498368073 1.200948585253499 1.1843691879003038 0.9981876246626138 1.1126245866372007 0.9472960680957119 0.9367747686890625 0.9948587496209269 1.0712214880544395 1.0 17.7187447302599 -6.3084974652588475 1.5316135129726052 0.9911553107034413 1.1198873598629808 0.2851468391363635 0.07603099362444156 0.46460752293817 2.1770939779756646 0.02881046153241306 0.037847288069742635 4.914762486709834e-07 6.3084974652588475 0.1287320491595395 AAAAGLGHPAS(ph)PGGSEDGPPGSEEEDAAR ddPTM_A459_Selumetinib_30min_R2 2 AAAAGLGHPASPGGSEDGPPGSEEEDAAR 29 0 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 AAAAGLGHPAS(0.998)PGGS(0.002)EDGPPGSEEEDAAR;AAAAGLGHPAS(0.904)PGGS(0.096)EDGPPGSEEEDAAR 144.06 6.5786e-15 15341700.0 26360.0 27375.0 35238.0 37427.0 40010.0 25673.0 24687.5 26480.0 27591.3 28408.0 True False 24895.01672744071 29474.57447550151 32970.825444233495 32329.378034823796 34983.58610606174 29209.222713709718 25835.51766735321 26557.052416 33110.33096533473 27587.78722715184 0.902392661015563 1.068392119774387 1.1951239573061403 1.171872820702535 1.2680823517310214 1.0587736694214485 0.9364838671050048 0.9626380034518538 1.2001807427580715 1.0 14.751742124590104 -6.99041721849232 24.936102807874835 1.0182716511303778 1.1289918352812114 0.14205318632524333 0.11125962194814495 369.1330522157132 960544.684210743 0.04118842155326269 0.03627733445400686 1.0223104061143538e-07 6.99041721849232 0.11072018415083362 AAAAPGAS(ph)PSPGGDAAWSEAGPGPR ddPTM_A459_Selumetinib_30min_R1 3 AAAAPGASPSPGGDAAWSEAGPGPR 25 0 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.864)PS(0.136)PGGDAAWSEAGPGPR;AAAAPGAS(0.89)PS(0.11)PGGDAAWSEAGPGPR;AAAAPGAS(0.991)PS(0.009)PGGDAAWSEAGPGPR 228.01 7.467699999999997e-39 19765200.0 3956.4500000000003 7428.0 4445.3 4028.8599999999997 4849.2 4517.4 6117.4 5362.4 2534.52 6013.5 True False 4048.6275870884388 6558.32630681649 3841.652676285051 3325.2952320686945 4410.590716195794 4471.959057471027 5655.9595928530025 5220.171732469963 4300.895325983301 6785.3913014503305 0.5966682549646138 0.9665361974650883 0.5661652372891043 0.49006683392863953 0.6500127288536861 0.6590569148923183 0.8335495097598985 0.7693250839276119 0.633846322917886 1.0 12.728216300362796 -7.247599143755226 22.379665943952702 0.789957304049749 0.6571953955033615 0.21254578273884428 0.14368135449152838 378.9884794738501 612824.8029293033 0.056560658128925634 0.04349232365967251 5.654586555314928e-08 7.247599143755226 -0.13276190854638747 AAAAPGAS(ph)PSPGGDAAWSEAGPGPR ddPTM_A459_Selumetinib_30min_R2 2 AAAAPGASPSPGGDAAWSEAGPGPR 25 0 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.976)PS(0.024)PGGDAAWSEAGPGPR;AAAAPGAS(0.991)PS(0.009)PGGDAAWSEAGPGPR 228.65 6.879699999999999e-39 24010400.0 53663.0 44104.0 55395.0 62412.0 71951.0 58143.0 61571.0 70704.0 66649.0 58760.0 True False 50680.62529000947 47486.63498328834 51830.94600951568 53911.37793329479 62911.87212989881 66151.6704803967 64434.173500621946 70909.73693432273 79980.66232865404 57063.446123185124 0.8881451915925862 0.832172576482273 0.9083038184834853 0.9447620428831823 1.1024898845766948 1.1592652560378578 1.129167231883005 1.24264729440362 1.4016093973013235 1.0 15.800279255012775 -6.333492661875019 1.0599405478358652 1.2180313149745314 0.8521647481282054 0.6837336746292715 0.0954090893462653 0.28123412330214376 0.6653679888881836 0.0427076483104763 0.060213504363926335 4.6398862977271e-07 6.333492661875019 -0.365866566846326 AAAAPGAS(ph)PSPGGDAAWSEAGPGPRPLAR ddPTM_A459_Selumetinib_30min_R1 1 AAAAPGASPSPGGDAAWSEAGPGPRPLAR 29 1 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.767)PS(0.233)PGGDAAWSEAGPGPRPLAR 122.68 7.3394e-14 163400000.0 2140.2 2317.4 2739.8 3158.0 2777.2 2026.2 2026.7 2079.9 1280.4 1697.9 True False 2190.062495895733 2046.0777306699697 2367.750208644137 2606.5145830018773 2526.002750354484 2005.8182676424042 1873.8243872944688 2024.7342955326485 2172.745283284023 1915.8420039465389 1.1431331453138167 1.0679783230846551 1.2358796830671264 1.3605060217035578 1.318481766842487 1.0469643444034105 0.9780683289303002 1.0568378244979477 1.1340941887735398 1.0 10.903762874169658 -6.782866868636676 24.48228677017165 1.0426748958937797 1.2245722454861456 0.5309657807323376 0.08552804738387285 175.3589200946627 200357.271716568 0.0343209007571047 0.030298451996446065 1.648667707043576e-07 6.782866868636676 0.18189734959236592 AAAAPGASPS(ph)PGGDAAWSEAGPGPR ddPTM_A459_Selumetinib_30min_R1 1 AAAAPGASPSPGGDAAWSEAGPGPR 25 0 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.166)PS(0.834)PGGDAAWSEAGPGPR 217.73 1.6006e-34 8255600.0 2606.0 4862.0 2420.0 2465.2 3525.8 2940.4 3996.4 3432.6 1651.1 3854.8 True False 2666.7147296067105 4292.75477971752 2091.3772921084783 2034.6990975352194 3206.8920125305494 2910.8222456695885 3694.948330479901 3341.5562973438005 2801.7961084272497 4349.601128931693 0.6130940862298524 0.9869306753587002 0.48082047758299673 0.4677898127258769 0.7372841595059534 0.6692159026509441 0.8494913029846989 0.7682443052346092 0.6441501244311567 1.0 12.086667392359871 -7.206365719027037 8.217401253001034 0.7960465400717888 0.6605509928545703 0.184435819420395 0.15890083363724045 0.7234918944238602 100.8725007382558 0.06254064364125496 0.04828721958667734 6.217764671936781e-08 7.206365719027037 -0.13549554721721846 AAAAPGASPS(ph)PGGDAAWSEAGPGPR ddPTM_A459_Selumetinib_30min_R2 2 AAAAPGASPSPGGDAAWSEAGPGPR 25 0 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.413)PS(0.556)PGGDAAWS(0.031)EAGPGPR;AAAAPGAS(0.082)PS(0.918)PGGDAAWSEAGPGPR 237.84 7.1238e-45 21550300.0 52963.0 40256.0 54401.0 62872.0 67523.0 59405.0 70223.0 78567.0 74769.0 57800.0 True False 50019.52848768744 43343.505756558465 50900.898887330324 54308.72513975051 59040.15707672097 67587.49952510136 73488.50864423465 78795.61696253301 89724.88922041073 56131.163817564666 0.8911186778570809 0.7721825597173051 0.9068206576433451 0.9675324979233038 1.0518249232923622 1.2040993795313355 1.3092283082368317 1.4037766474721862 1.5984861727084634 1.0 15.776514351844536 -6.640809381942008 1.0839859643748266 1.373223316024856 0.8458556203635311 0.6639382784236627 0.14347755204974746 0.2715687330773605 0.6822305263412448 0.07081436307296969 0.07229173154455312 2.2866022055591997e-07 6.640809381942008 -0.5273676956613248 AAAAPGASPS(ph)PGGDAAWSEAGPGPRPLAR ddPTM_A459_Selumetinib_30min_R1 1 AAAAPGASPSPGGDAAWSEAGPGPRPLAR 29 1 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.034)PS(0.966)PGGDAAWSEAGPGPRPLAR 104.05 5.2342e-09 206050000.0 1378.0 1806.5 2464.3 2145.3 1898.4 1558.5 1524.4 1780.1 850.82 1189.5 True False 1410.1047188787595 1594.9941401809338 2129.6615954309614 1770.6636272685005 1726.6900551897425 1542.82290500478 1409.4132806985192 1732.885965420293 1443.7793985658477 1342.1839117111786 1.0506046947627223 1.1883573676184527 1.586713696125154 1.3192406881192937 1.2864779857093869 1.1494869604254179 1.0500895357191613 1.2910942757546542 1.0756941623038403 1.0 10.390366653916004 -6.77603288804595 4.2742364548299765 1.1249977275059246 1.3009635197686935 0.261268640526241 0.14445474507390965 0.320197516608056 13.521531722905019 0.05386009951297315 0.04976094143814579 1.674816041551511e-07 6.77603288804595 0.17596579226276887 AAAAPGASPS(ph)PGGDAAWSEAGPGPRPLAR ddPTM_A459_Selumetinib_30min_R2 3 AAAAPGASPSPGGDAAWSEAGPGPRPLAR 29 1 P52701-2;P52701;P52701-3;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 AAAAPGAS(0.271)PS(0.728)PGGDAAWS(0.001)EAGPGPRPLAR;AAAAPGAS(0.121)PS(0.874)PGGDAAWS(0.005)EAGPGPRPLAR;AAAAPGAS(0.339)PS(0.661)PGGDAAWSEAGPGPRPLAR 78.352 2.3205e-05 303351000.0 71474.0 70491.0 87655.0 98870.0 93184.0 72757.0 63900.0 66943.0 58693.0 76299.0 True False 67501.76121309174 75897.43303571074 82015.37273154789 85403.73543973667 81477.39284447035 82778.61632771304 66871.47661544778 67137.79304698971 70433.24001944071 74096.04962139059 0.9110035090670319 1.0243114636141157 1.1068791541603467 1.152608484205637 1.0996185796786238 1.1171798867913723 0.9024971905674016 0.9060913961006618 0.950566735734688 1.0 16.177109007862597 -7.2649313494584105 24.955237937035488 0.931963108930832 1.0735554971458352 0.46533986339103506 0.06730753420561351 274.61590761718685 1962519.1559957173 0.02952462411433854 0.02079233583711023 5.433362118773324e-08 7.2649313494584105 0.1415923882150032 AAAGAQASQAQLGEAAGPASETPAGTESPHS(ph)SASPCQEHK ddPTM_A459_Selumetinib_30min_R2 1 AAAGAQASQAQLGEAAGPASETPAGTESPHSSASPCQEHK 40 0 Q9Y261;Q9Y261-2 Q9Y261 FOXA2 Hepatocyte nuclear factor 3-beta 1 AAAGAQASQAQLGEAAGPAS(0.091)ET(0.091)PAGT(0.029)ES(0.048)PHS(0.366)S(0.263)AS(0.112)PCQEHK 83.868 3.65e-10 11769000.0 12264.0 8542.9 23583.0 33462.0 38055.0 21094.0 17458.0 16986.0 21812.0 30972.0 True False 11582.415976681817 9198.112960247005 22065.695455228968 28904.417874830313 33274.190683983514 23999.507027733154 18269.831592370727 17035.426447816324 26175.00947820077 30077.757885079798 0.38508242605501275 0.30581112446582226 0.7336216861488453 0.9609897780701425 1.1062723096288145 0.7979154270550936 0.6074199966026576 0.5663795324407084 0.8702447030197352 1.0 14.876409406384258 -5.335601500013836 4.302259040818168 0.8260277462106316 0.34335362410039544 0.6039849875825991 0.15829288186049095 0.15850603430030047 5.542609929287408 0.0473627954640551 0.10754951634642682 4.617410646626922e-06 5.335601500013836 -0.48267412211023614 AAAGEEETAAAGS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 AAAGEEETAAAGSPGR 16 0 Q9NS37;E9PIM0 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 AAAGEEETAAAGS(1)PGR 155.37 9.1547e-05 9492800.0 6289.1 5099.5 7232.6 7002.3 7237.5 6358.1 4696.2 7337.7 5151.8 6616.7 True False 5939.576999262037 5490.615252523101 6767.262390259469 6048.574660358743 6328.260545929065 7233.87056191477 4914.582605343761 7359.0514921783715 6182.303953319036 6425.6586787487895 0.9243530190773528 0.854482867364539 1.0531624427298707 0.9413158965886012 0.9848423114751109 1.1257788381818246 0.764837170949879 1.1452602542547954 0.9621276607432345 1.0 12.649628633732444 -5.2541587636515015 24.94678892393784 0.9962145787357096 0.8894179397750239 0.15331743153623245 0.10126225396675576 976.7604732387828 3346816.054312265 0.024385645768488555 0.06175562720560669 5.5698209753743614e-06 5.2541587636515015 -0.1067966389606857 AAAGEEETAAAGS(ph)PGRK ddPTM_A459_Selumetinib_30min_R1 2 AAAGEEETAAAGSPGRK 17 1 Q9NS37;E9PIM0 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 AAAGEEET(0.001)AAAGS(0.999)PGRK;AAAGEEETAAAGS(1)PGRK 195.6 1.6926e-07 10003400.0 2503.4 2719.8 3277.5 3250.8 3111.5 2373.1 2701.3 2310.5 1455.67 1749.25 True False 2561.724349231559 2401.364551599283 2832.433502018818 2683.1088050736225 2830.065374379944 2349.228768602403 2497.5387661708946 2249.2180344382846 2470.1656720697074 1973.7832766378954 1.2978751920500364 1.2166303058812624 1.4350276119694008 1.35937356285842 1.4338278208540824 1.1902161683140988 1.2653561288781179 1.139546606286765 1.251487790633904 1.0 10.946747873805624 -8.410187146853676 0.5270592226810362 1.0041269781191784 1.3423329100899308 0.5847180352697168 0.08179611734690613 0.679266951458276 0.4688769148558303 0.09337724520088359 0.04580540615741816 3.8887753317161665e-09 8.410187146853676 0.33820593197075244 AAAGEEETAAAGS(ph)PGRK ddPTM_A459_Selumetinib_30min_R2 2 AAAGEEETAAAGSPGRK 17 1 Q9NS37;E9PIM0 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 AAAGEEETAAAGS(1)PGRK;AAAGEEETAAAGS(1)PGRK 156.0 0.00056949 0.0 14433.0 16006.2 16361.6 16780.9 17565.199999999997 13100.599999999999 9391.400000000001 13867.900000000001 9679.1 18713.4 True False 13630.871639876765 17233.824071955147 15308.912469163131 14495.312471332853 15358.502541119624 14905.08873459377 9828.118708706059 13908.25329304557 11615.19045665016 18173.09551874766 0.7500577777635591 0.9483152748620318 0.8423943215051177 0.7976248436255261 0.845123084577173 0.8201733556739103 0.540805978737481 0.7653210912085721 0.6391421012819605 1.0 14.149516561871915 -7.029429812128789 24.94055224781943 0.71157912454071 0.8402088709679532 0.12655176640915755 0.11922329021267015 1036.984077525308 878798.320758152 0.042294910194583805 0.032819082041233814 9.34480380742116e-08 7.029429812128789 0.12862974642724312 AAAGPLDMSLPST(ph)PDIK ddPTM_A459_Selumetinib_30min_R2 1 AAAGPLDMSLPSTPDIK 17 0 K7ELQ4;P17544-2;P17544;P17544-4 K7ELQ4 ATF7 Cyclic AMP-dependent transcription factor ATF-7 1 AAAGPLDMSLPS(0.033)T(0.967)PDIK 118.51 0.0029062 0.0 14461.0 13148.0 12024.0 12717.0 12916.0 9571.5 12762.0 12321.0 10635.0 13670.0 True False 13657.315511969644 14156.409322516674 11250.388930741341 10984.922661951385 11293.376609494962 10889.887243573896 13355.458287423253 12356.85207014865 12762.297166727727 13275.311581074553 1.0287755152534184 1.0663711534046572 0.8474670339775703 0.8274700442897043 0.8507052011942935 0.8203112354137625 1.0060372749716064 0.9308144667402557 0.9613557534063317 1.0 13.696458102062556 -10.300804144905555 14.78563838375848 0.9999995032188858 0.9225612597269112 0.06229931824813617 0.0841450946270682 0.0 0.0 0.08950033925822008 0.02170702072295626 5.002600879170716e-11 10.300804144905555 -0.07743824349197459 AAAGVGGS(ph)LR ddPTM_A459_Selumetinib_30min_R2 2 AAAGVGGSLR 10 0 Q9BRK4 Q9BRK4 LZTS2 Leucine zipper putative tumor suppressor 2 1 AAAGVGGS(1)LR;AAAGVGGS(1)LR 86.189 0.035409 40994000.0 72362.0 80493.0 89341.0 95022.0 91499.0 72070.0 65455.0 60373.0 58257.0 82243.0 True False 68340.40972803725 86666.55427421177 83592.89732712612 82079.83967790692 80004.07760856154 81996.98831367819 68498.7871966219 60548.675434711826 69910.02783658271 79868.43089702362 0.8556623557078549 1.085116526027075 1.0466325228663194 1.0276881460678065 1.0016983770685668 1.0266507979779766 0.8576453353007412 0.7581052332526572 0.8753149029147633 1.0 16.285337750184702 -7.265826353817803 22.825411946724024 0.8526084292832882 1.0132491781697928 0.39811214366962044 0.07926573235161462 95.64219306380836 497617.98496955907 0.03109845481753751 0.02184114365827442 5.422176447176783e-08 7.265826353817803 0.1606407488865046 AAALPEET(ph)RS(ph)S(ph)RRR ddPTM_A459_Selumetinib_30min_R1 1 AAALPEETRSSRRR 14 3 H3BS19;Q96JG9 H3BS19 ZNF469 Zinc finger protein 469 3 AAALPEET(1)RS(1)S(1)RRR 94.692 0.039127 0.0 813.73 764.47 783.09 1157.3 993.78 673.12 773.94 609.91 180.48 443.18 True False 832.6883257570486 674.9654970075389 676.7506792054664 955.1992802115486 903.8927744661095 666.3490239440599 715.5610826973317 593.7332055331111 306.26137826234003 500.066469938764 1.6651552859743146 1.3497515582082364 1.3533214480233766 1.910144626030452 1.8075452540875143 1.3325209027225084 1.4309319374781442 1.187308570410284 0.6124413386481271 1.0 8.96597606361688 -7.874080927196185 1.8635790404434107 0.8083882578389565 1.5705014901444756 0.6739458958073734 0.2074616537731917 0.22101813896155312 1.4443467005185773 0.17362805718922614 0.06363552791186244 1.3363464761954532e-08 7.874080927196185 0.7621132323055191 AAAPPQPS(ph)PPPTK ddPTM_A459_Selumetinib_30min_R2 1 AAAPPQPSPPPTK 13 0 J3KR72;P49848-4;P49848-2;P49848;P49848-3 J3KR72 TAF6 Transcription initiation factor TFIID subunit 6 1 AAAPPQPS(0.989)PPPT(0.011)K 103.83 0.008165899999999999 7138100.0 46246.0 38960.0 42695.0 47836.0 43468.0 29134.0 45367.0 40370.0 38900.0 38224.0 True False 43675.832457406024 41948.106723855315 39948.05018280123 41320.65427829726 38007.161231149505 33146.94404787984 47476.65539300507 40487.470016386746 46681.086956813226 37120.37380212099 1.1766000172905176 1.13005615049756 1.0761758595361632 1.1131529681938785 1.0238895069795295 0.8929582504900824 1.2789918454509839 1.0907074975110669 1.2575597219375512 1.0 15.179923618025466 -10.200199519157936 10.905198921395767 0.9999971490973019 1.1095943391859195 0.09514507404125983 0.1054800459092248 0.0 0.0 0.10294380365241683 0.024967539762456456 6.306675430421703e-11 10.200199519157936 0.10959719008861768 AAAPPQPSPPPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 AAAPPQPSPPPTK 13 0 J3KR72;P49848-4;P49848-2;P49848;P49848-3 J3KR72 TAF6 Transcription initiation factor TFIID subunit 6 1 AAAPPQPS(0.246)PPPT(0.754)K 108.66 0.014336000000000003 0.0 38115.0 32281.0 36603.0 42778.0 42824.0 27360.0 31288.0 36911.0 29764.0 37937.0 True False 35996.720886434094 34756.84890022515 34248.00283033311 36951.56260383392 37444.06626858258 31128.591650648486 32742.953995995842 37018.40489905499 35717.631675644974 36841.660237836506 0.9770656548606174 0.9434115801472419 0.9295998771293239 1.0029831002535694 1.016351218345133 0.8449291223493592 0.8887480581661931 1.0047974130394093 0.9694902847772003 1.0 15.16905045625892 -7.809886821755705 24.999378765590006 0.990357957793664 0.9440974019723063 0.17055199277978828 0.04860096895821201 248.89904270962583 128431.16790237003 0.02882247589639575 0.01384591475604167 1.5492202970520116e-08 7.809886821755705 -0.046260555821357685 AAAPS(ph)PDRR ddPTM_A459_Selumetinib_30min_R2 1 AAAPSPDRR 9 1 Q9UL51 Q9UL51 HCN2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 1 AAAPS(1)PDRR 67.214 0.042581 2232300.0 9400.3 4828.9 10072.0 10599.0 8462.2 7599.4 10380.0 9855.9 8566.0 7362.8 True False 8877.868958382423 5199.261102639238 9423.97848556444 9155.397915705173 7399.10278297215 8646.148369515282 10862.690567579799 9884.579037267922 10279.439354037588 7150.2168331481835 1.2416223403498616 0.7271473332858417 1.317998978978535 1.2804364020488206 1.0348081681481516 1.2092148491821963 1.5192113499580464 1.3824166830078943 1.4376402274099473 1.0 12.803771277513153 -7.026152152925657 9.173369950843302 1.3665767118290448 1.1186870637045807 0.19533299862835374 0.20107711268880837 0.5193989827356378 173.64555984282998 0.07419998686746157 0.05899382160954452 9.415596679548691e-08 7.026152152925657 -0.24788964812446412 AAASPPT(ph)PIR ddPTM_A459_Selumetinib_30min_R2 2 AAASPPTPIR 10 0 Q6PGN9-4;Q5T2Z1;Q6PGN9-2 Q6PGN9-4 PSRC1 1 AAAS(0.091)PPT(0.909)PIR;AAAS(0.148)PPT(0.852)PIR 101.97 0.036914 8498800.0 78826.0 72666.0 81930.0 87031.0 87590.0 69236.0 60792.0 69293.0 64147.0 78802.0 True False 74445.16648547957 78239.24854198315 76658.7129986391 75177.22766315108 76586.16113546494 78772.63053816879 63618.948457062725 69494.63115792634 76978.19241693318 76526.78150781558 0.9727988688231528 1.0223773560108846 1.001723991107741 0.9823649470410999 1.0007759326405656 1.0293472296378208 0.8313292053261825 0.9081086358091375 1.0058987311399146 1.0 16.22367710496097 -7.196331714564924 24.99999803317315 0.9286741112173171 1.0016094371281785 0.2993566656312907 0.04832374423786491 225.82990555234986 86713.707878209 0.018299280648229905 0.014174560283294267 6.363093215478218e-08 7.196331714564924 0.07293532591086138 AAAT(ph)PESQEPQAK ddPTM_A459_Selumetinib_30min_R1 3 AAATPESQEPQAK 13 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 AAAT(0.903)PES(0.097)QEPQAK;AAAT(1)PESQEPQAK;AAAT(1)PESQEPQAK 203.29 0.00014065 44070000.0 15364.4 17140.2 18832.1 18947.2 16947.699999999997 16249.900000000001 15963.400000000001 15057.300000000001 8708.0 13450.0 True False 15722.36062608187 15133.417415737204 16274.804257320688 15638.427202993393 15414.78352735946 16086.440759728708 14759.267885792924 14657.931490996567 14776.839992843852 15176.438514094441 1.0359716880531904 0.9971652704738807 1.0723730895233547 1.030441179494774 1.0157049371658353 1.059961515001635 0.9725119547702784 0.9658347363502752 0.973669809232286 1.0 13.889545649822217 -7.276030466112089 24.761247489655737 0.9751570127656106 1.0341153413204538 0.6316466560824394 0.021368584046657643 452.90903975018284 768588.4955387913 0.00873525558210645 0.005918285527966725 5.296262888723511e-08 7.276030466112089 0.058958328554843176 AAAT(ph)PESQEPQAK ddPTM_A459_Selumetinib_30min_R2 2 AAATPESQEPQAK 13 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 AAAT(1)PESQEPQAK;AAAT(0.995)PES(0.005)QEPQAK 168.0 1.2605e-06 0.0 117456.0 105164.0 110920.0 111033.0 102626.0 70720.0 90249.0 94580.0 78769.0 92220.0 True False 110928.26573362201 113229.7406444433 103783.5279605645 95910.11385739157 89733.20439191945 80461.03806775811 94445.75732500092 94855.21214143805 94525.00098974879 89557.36898366446 1.2386280100954692 1.2643263410864243 1.1588496752232074 1.0709349207755965 1.0019633829158945 0.8984301234043002 1.0545838761992674 1.0591558597343333 1.0554687130993146 1.0 16.45052452486842 -5.672592979692272 1.9299678582195354 1.0120720467817104 1.2531547063181336 0.8190623039804431 0.04513260127622723 0.14630316866084678 1.1008906298264611 0.015073159714212496 0.033283426733854336 2.125235297118345e-06 5.672592979692272 0.24108265953642327 AAATGNAS(ph)PGKLEHSK ddPTM_A459_Selumetinib_30min_R1 2 AAATGNASPGKLEHSK 16 1 H0Y6H0;Q8NB78 H0Y6H0 KDM1B Lysine-specific histone demethylase 1B 1 AAAT(0.06)GNAS(0.939)PGKLEHS(0.001)K;AAAT(0.016)GNAS(0.957)PGKLEHS(0.027)K 75.358 0.017039 111108000.0 8885.6 9261.2 11990.1 12149.3 9977.0 9571.6 9595.6 9789.900000000001 5663.4 8227.5 True False 9092.617191632147 8176.894398584929 10361.9102769049 10027.652825606305 9074.582111582411 9475.31839431746 8871.796166538119 9530.240049923115 9610.376161629745 9283.579767636582 0.9794300710734293 0.8807910960263776 1.1161546015931785 1.0801493687342065 0.9774873851159489 1.0206535228306324 0.9556438775337528 1.0265695225829172 1.0352015496363165 1.0 13.18046550350258 -5.244901313503245 24.998024611425347 1.0248601172926544 0.9301105883832216 0.38170014858490986 0.0490276132894603 897.5947286313279 1356749.324767255 0.012913076296430327 0.03397008630973084 5.689822082903225e-06 5.244901313503245 -0.09474952890943278 AAAYDIS(ph)EDEED ddPTM_A459_Selumetinib_30min_R2 2 AAAYDISEDEED 12 0 P49585 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 1 AAAYDIS(1)EDEED;AAAYDIS(1)EDEED 101.95 0.012057 9180400.0 93290.0 100290.0 98112.0 95979.0 115266.0 80847.0 82334.0 81659.0 82815.0 85297.0 True False 88105.31526945914 107981.92051682365 91799.58073626892 82906.49462699004 100785.25458888561 91982.94039400492 86162.694141726 81896.61417062487 99380.31404443405 82834.25398177883 1.0636338354521764 1.303590185535764 1.1082321180373302 1.0008721107722791 1.2167098723561327 1.1104456909123432 1.0401819295756478 0.9886805305042017 1.1997490080165976 1.0 16.337939860202198 -1.5228787452803532 0.08188743997120107 0.9254385647848803 1.5877462782108902 0.12951422910788257 0.09432651921249967 346.06632760304626 2.0687243254892427 2.4591818564535437 25.88625902320927 0.029999999999998923 1.5228787452803532 0.6623077134260099 AADAEAEVAS(ph)LNRR ddPTM_A459_Selumetinib_30min_R2 1 AADAEAEVASLNRR 14 1 J3KN67;A0A2R2Y2Q3;A0A494C0P6;P06753 J3KN67 TPM3 Tropomyosin alpha-3 chain 1 AADAEAEVAS(1)LNRR 79.32600000000002 0.018619 4047800.0 23777.0 21392.0 25874.0 25754.0 31254.0 21605.0 20071.0 26842.0 19643.0 19388.0 True False 22455.569526872434 23032.697613878663 24209.295009481164 22246.260771871985 27327.593105694927 24580.892639337006 21004.341269931996 26920.10577606768 23572.14887127718 18828.218063926353 1.1926550590518097 1.2233073536580619 1.28579852470822 1.1815383004562912 1.4514168580856213 1.305534732807902 1.115577756674433 1.4297744844821434 1.2519585651304883 1.0 14.200608846735532 -8.56981481011329 22.110650135124164 0.9999999990219272 1.2750536122222182 0.39965543463938613 0.09986588683804752 8315.269738932793 3917151.1491668043 0.09534623911344325 0.024618292973176713 2.6926827607479985e-09 8.56981481011329 0.2750536132002911 AADAEAEVASLNRR ddPTM_A459_Selumetinib_30min_R2 1 AADAEAEVASLNRR 14 1 J3KN67;A0A2R2Y2Q3;A0A494C0P6;P06753 J3KN67 TPM3 Tropomyosin alpha-3 chain 0 129.76 0.0013888 4481100.0 20138.0 22710.0 26215.0 30517.0 34216.0 15083.0 10824.0 15107.0 16265.0 23873.0 False True 19018.81057880124 24451.783975840703 24528.355440733896 26360.531955238683 29917.480185078963 17160.546340158297 11327.3374473491 15150.958868901518 19518.454482071127 23183.72446049691 0.8203518210030348 1.0546961087941007 1.0579989199978685 1.1370274866816497 1.2904518528097502 0.7401979940452798 0.48859006526970755 0.6535170349663817 0.841903315204117 1.0 14.500824733169898 -6.863816005639316 7.900156466958824 0.7034022383859247 1.0732679299591885 0.4888785349891108 0.16491118033007476 0.19094905181083743 13.160171152542128 0.05893561653037683 0.05201048001548884 1.3683084040090193e-07 6.863816005639316 0.36986569157326377 AADEEAFEDNSEEYIRR ddPTM_A459_Selumetinib_30min_R1 2 AADEEAFEDNSEEYIRR 17 1 P55060-4;P55060-3;P55060 P55060-4 CSE1L Exportin-2 0 ; 231.17 2.448e-16 25848000.0 3182.9 3083.2 5172.0 5043.1 4332.7 3348.6 3021.9 3391.4 2102.4 2245.16 False True 3257.055377154718 2722.2175106592053 4469.670807762421 4162.417255711454 3940.8080500003157 3314.916124285535 2793.955650054353 3301.4490551802605 3567.61924677939 2533.348155710356 1.2856722317511202 1.0745532565364628 1.7643334169002587 1.6430498296608205 1.5555730234383458 1.3085118667220952 1.1028707774557431 1.3031959494941696 1.4082625156505668 1.0 11.306829643592128 -6.94255065603547 5.752679680637371 1.2255013049845718 1.468134834433756 0.26416662929530577 0.2048718849455916 0.3208663990650023 21.861610027086268 0.07935014324841934 0.06941305843697115 1.1414301606317105e-07 6.94255065603547 0.24263352944918415 AADEEAFEDNSEEYIRR ddPTM_A459_Selumetinib_30min_R2 2 AADEEAFEDNSEEYIRR 17 1 P55060-4;P55060-3;P55060 P55060-4 CSE1L Exportin-2 0 ; 148.18 0.00048052 8217000.0 27250.0 23152.9 31113.0 33893.0 31128.0 23661.0 21779.0 26146.0 20518.2 29889.0 False True 25735.55409039299 24928.652981692732 29111.223453273087 29276.714931313858 27217.42235214922 26920.087976827246 22791.766654269803 26222.080531296688 24622.41332640838 29026.026909051725 0.8866371608843026 0.8588379339619081 1.002935177607611 1.008636663331417 0.9376902473573298 0.9274465313898078 0.785218270681139 0.9033988913969955 0.8482874147246765 1.0 14.825059488514153 -7.024423403818935 24.629392759600318 0.8733412396403909 0.9409879203247904 0.1267214376075093 0.06592918237065232 1102.528599222255 1111823.7788773756 0.02543221478753741 0.019808712050969464 9.453151022307367e-08 7.024423403818935 0.0676466806843995 AADGGERPLAAS(ph)PPGTVK ddPTM_A459_Selumetinib_30min_R1 2 AADGGERPLAASPPGTVK 18 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785;O95785-2 B9EGQ5 WIZ Protein Wiz 1 AADGGERPLAAS(1)PPGTVK;AADGGERPLAAS(0.972)PPGT(0.028)VK 127.01 0.0035563 16040300.0 4069.1000000000004 4278.4 5502.0 5528.0 4579.200000000001 4012.1 3995.1 4187.4 2541.13 3700.6000000000004 True False 4163.9021129096955 3777.4829390257996 4754.858620322664 4562.638573411772 4165.0121685234235 3971.7419166953323 3693.746390526539 4076.3365494078644 4312.112013208004 4175.608056896497 0.9971965893763741 0.9046545766638351 1.1387224460565613 1.092688420762109 0.9974624322425154 0.9511768974905448 0.8846008390145459 0.9762258559385921 1.032690797232766 1.0 12.027770584474801 -6.522940269618844 7.918763120445131 0.9633768585781568 1.0333510992235906 0.16699034605853802 0.0672019266894683 0.21879740212710352 120.14793207555459 0.02353542670366256 0.024566897759046028 2.9995750350279446e-07 6.522940269618844 0.06997424064543378 AADGGERPLAASPPGT(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 AADGGERPLAASPPGTVK 18 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785;O95785-2 B9EGQ5 WIZ Protein Wiz 1 AADGGERPLAAS(0.353)PPGT(0.647)VK 122.13 0.0089895 0.0 13232.0 12977.0 14962.0 14854.0 15660.0 13104.0 13396.0 10965.0 9528.2 12227.0 True False 12496.618411892849 13972.294172368322 13999.361209393883 12830.859575420765 13692.650797823719 14908.957053731636 14018.940543670427 10996.906334646535 11434.10624015187 11873.974740438813 1.05243767862614 1.176715840971375 1.1789953672140392 1.0805867332463763 1.153164891886716 1.2555995258232007 1.180644295622979 0.9261352306228786 0.9629552437239994 1.0 13.535515328720123 -7.759944862238667 24.999999999847383 0.9584088955774291 1.1569036817167544 0.7133763684627646 0.05543334214953175 20.913744724451483 349861.83603660204 0.028832013411763564 0.015492415631674994 1.7380214728839796e-08 7.759944862238667 0.19849478613932525 AADKS(ph)PESQNLIDGTK ddPTM_A459_Selumetinib_30min_R1 2 AADKSPESQNLIDGTK 16 1 Q9HCE3 Q9HCE3 ZNF532 Zinc finger protein 532 1 AADKS(0.825)PES(0.175)QNLIDGTK;AADKS(0.99)PES(0.01)QNLIDGTK 97.621 0.004138 58785000.0 10655.4 12326.9 11558.599999999999 12728.4 10961.400000000001 10583.1 11547.5 10799.5 6716.1 10994.6 True False 10903.650088200819 10883.660817379665 9989.005606845063 10505.623881659616 9969.943305392359 10476.643622685977 10676.46277805441 10513.062178280132 11396.731175463774 12405.86400647307 0.8789109797198782 0.8772997037288852 0.8051841936710776 0.8468272646047098 0.803647637938824 0.8444912516548244 0.8605980826876467 0.847426843692199 0.9186567875899047 1.0 13.598734594783567 -8.542585364944072 1.7771474595177466 1.0001221247270986 0.8428624945728869 0.8045491736543312 0.024117970350902056 0.16649153585112883 1.1835372259911456 0.024075092236436266 0.006861118743611722 2.8669137994817233e-09 8.542585364944072 -0.15725963015421174 AADKS(ph)PESQNLIDGTK ddPTM_A459_Selumetinib_30min_R2 2 AADKSPESQNLIDGTK 16 1 Q9HCE3 Q9HCE3 ZNF532 Zinc finger protein 532 1 AADKS(0.999)PES(0.001)QNLIDGTK;AADKS(1)PESQNLIDGTK 84.113 0.0095976 60325000.0 254610.0 216220.0 230020.0 229680.0 207845.0 171388.0 213090.0 194023.0 158905.0 203040.0 True False 240459.79548458534 232803.37874312047 215220.7636268403 198397.1877799 181733.65294212478 194995.14129463944 222999.10722982476 194587.57480776333 190690.44017666846 197177.7076387251 1.2195080182449578 1.1806779860209642 1.0915065714283188 1.0061846755182349 0.9216744383452444 0.9889309680580898 1.1309549639273138 0.9868639672203335 0.9670993869451875 1.0 17.5891369282976 -5.420830816821667 2.071374651637792 1.0011770149451233 1.2119763635524445 0.7190360039573154 0.05016208056260748 0.1962915208434147 1.601800430444806 0.01571203003513869 0.04615174973692505 3.7946277919801228e-06 5.420830816821667 0.2107993486073212 AADPPAENS(ph)SAPEAEQGGAE ddPTM_A459_Selumetinib_30min_R1 1 AADPPAENSSAPEAEQGGAE 20 0 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 AADPPAENS(0.5)S(0.5)APEAEQGGAE 132.51 0.00014339 41277000.0 5994.4 5303.4 6227.0 6215.8 6129.7 5225.4 5967.7 5430.4 3232.6 4382.1 True False 6134.057856928036 4682.475462516227 5381.407602462603 5130.3272150168 5575.269717286429 5172.837220283591 5517.551584377168 5286.368151574836 5485.486100237374 4944.585220268647 1.2405606504229212 0.9469905470173735 1.0883435844938723 1.0375647271659445 1.1275505363791698 1.0461620115433146 1.1158775384757937 1.0691226697651333 1.10939256901701 1.0 12.271633789314947 -11.396142146426305 2.4009531059204874 0.9594807031350874 1.0816560630092562 0.11406213638275498 0.07130068600851436 31275013.900123008 18052708.48250718 7219572.635481545 0.016914217243777473 4.016593245312476e-12 11.396142146426305 0.12217535987416883 AADPPAENSS(ph)APEAEQGGAE ddPTM_A459_Selumetinib_30min_R1 1 AADPPAENSSAPEAEQGGAE 20 0 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 AADPPAENS(0.23)S(0.77)APEAEQGGAE 174.4 3.7947e-10 28300000.0 1717.8 2328.4 2178.4 2584.2 2312.7 1693.8 1645.6 1712.6 1082.0 1719.9 True False 1757.821397743058 2055.7898455562076 1882.585245094673 2132.917981441878 2103.516693340347 1676.761909847351 1521.4710671198395 1667.176284691195 1836.0749738466986 1940.6659182446867 0.9057825879340378 1.0593218679367797 0.9700717817507986 1.0990649969115145 1.083914894142603 0.864013684212049 0.783994325255114 0.8590743357821935 0.9461056416693351 1.0 10.922336067023275 -6.7723040817213676 24.99727067854076 0.8751645053883557 1.0268292796442213 0.43104479561318687 0.07531138577496516 185.58219215335603 426980.99637842964 0.026466445010520544 0.02356659312821466 1.6892577430563208e-07 6.7723040817213676 0.15166477425586566 AADPPAENSS(ph)APEAEQGGAE ddPTM_A459_Selumetinib_30min_R2 2 AADPPAENSSAPEAEQGGAE 20 0 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 AADPPAENS(0.195)S(0.805)APEAEQGGAE;AADPPAENS(0.234)S(0.766)APEAEQGGAE 163.0 4.2889e-07 81698000.0 205400.0 180235.0 222240.0 234260.0 241190.0 190170.0 166595.0 178783.0 177737.0 213890.0 True False 193984.69028134728 194058.44495313306 207941.32035661678 202353.38387895934 210889.55593404226 216364.19130861934 174341.99760172993 179303.22893088122 213289.36638671212 207714.43994703944 0.933900841611239 0.9342559188596218 1.0010922707618939 0.9741902581763358 1.015285966578984 1.0416425134611984 0.8393349910876758 0.8632198559551172 1.0268393783364032 1.0 17.664241987758757 -9.429594927485358 12.384301862576303 1.0 0.9575972870425807 0.03519875236726 0.06430598920383258 0.0 0.0 0.06604438533789209 0.016018116278066083 3.718819268420224e-10 9.429594927485358 -0.042402712957419264 AADPPAENSSAPEAEQGGAE ddPTM_A459_Selumetinib_30min_R1 1 AADPPAENSSAPEAEQGGAE 20 0 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 93.348 0.017554 5793000.0 1561.4 2300.4 1533.5 2035.1 2264.1 1731.3 1731.4 2011.2 1366.5 2059.7 False True 1597.7775820444817 2031.068098573053 1325.2591229125424 1679.707988558303 2059.3125547593204 1713.884693894627 1600.799104041863 1957.8564427017004 2318.8506947888295 2324.0825581769764 0.6874874459269587 0.8739225254399888 0.5702289353920728 0.7227402411538579 0.8860754741753482 0.7374457021178318 0.6887875382953431 0.8424212108185409 0.9977488478755889 1.0 11.182445603041785 -8.105799417703407 2.9938263925052375 1.001801422716888 0.7422423541202756 0.5881952476702714 0.08644833376002986 0.19414880309827043 3.143129911120228 0.0708544262031638 0.023204514447340382 7.837915594328021e-09 8.105799417703407 -0.2595590685966125 AADPPAENSSAPEAEQGGAE ddPTM_A459_Selumetinib_30min_R2 1 AADPPAENSSAPEAEQGGAE 20 0 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 174.94 1.2819e-10 0.0 26641.0 24015.0 28499.0 35126.0 28446.0 25413.0 23941.0 26122.0 23638.0 25416.0 False True 25160.39987237281 25856.87327960435 26665.405367365063 30341.778204270195 24872.359169533433 28913.41007375472 25054.303938191515 26198.0106952701 28366.260500903627 24682.17404130145 1.0193753528465983 1.0475930214387614 1.08035075527565 1.2292992567631342 1.007705363713656 1.1714288224924194 1.0150768686853666 1.0614142275891967 1.149261019448185 1.0 14.591181854282626 -5.175650035015169 3.3623336186460944 1.0939988654507433 1.0266414310223002 0.09174851220484481 0.07152431997117915 0.5639327126127025 12.025273281777052 0.018030804287644746 0.05815320536187336 6.673443147709104e-06 5.175650035015169 -0.06735743442844311 AADPVPSFDESS(ph)QDTSEK ddPTM_A459_Selumetinib_30min_R1 2 AADPVPSFDESSQDTSEK 18 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 AADPVPSFDES(0.002)S(0.998)QDTSEK;AADPVPSFDES(0.226)S(0.774)QDTSEK 305.43 3.115099999999998e-96 19029200.0 6813.9 15303.8 8305.4 11068.400000000001 7517.299999999999 10075.5 9210.1 7131.6 4023.0 6434.5 True False 6972.650612458621 13512.023981456392 7177.5722982966 9135.511719600378 6837.361542287111 9974.149617822051 8515.374741905955 6942.446801298449 6826.737171705422 7260.430752337602 0.9603632140164238 1.861049907693975 0.9885876669212327 1.258260292154025 0.9417294614490638 1.3737683008147592 1.1728470434298 0.956203156274609 0.9402661363456231 1.0 12.82583942872694 -6.602070157289255 0.40021751672258987 0.9517472656311653 1.3871983383638367 0.14549921972051827 0.2576923516130382 2.8200661168170016 0.8922457775470053 0.2576618627596347 0.49713826600745387 2.499941480707592e-07 6.602070157289255 0.43545107273267136 AADPVPSFDESS(ph)QDTSEK ddPTM_A459_Selumetinib_30min_R2 1 AADPVPSFDESSQDTSEK 18 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 AADPVPSFDES(0.213)S(0.786)QDT(0.001)SEK 180.02 1.4363e-09 7740500.0 75486.0 68800.0 78468.0 61434.0 56728.0 48160.0 51581.0 60392.0 44801.0 64137.0 True False 71290.79031440026 74076.73877313249 73419.45430949856 53066.5832204389 49601.32148524549 54793.60284704792 53979.61870581251 60567.73072156618 53762.45184452929 62285.19816206134 1.144586393205446 1.189315294147262 1.178762474488188 0.8519934878004835 0.7963580906684544 0.879721096888528 0.8666524358702633 0.9724257529690049 0.8631657830588174 1.0 15.926601732599671 -5.758359587305497 24.999155039606993 0.8835877899425107 1.1727308533872614 0.8383726584823046 0.0564566900485051 28.664876374473405 232672.14380694227 0.01572235893019304 0.02581187180846929 1.7443772447100167e-06 5.758359587305497 0.2891430634447506 AADRLPNLS(ph)SPSAEGPPGPPSGPAPR ddPTM_A459_Selumetinib_30min_R1 3 AADRLPNLSSPSAEGPPGPPSGPAPR 26 1 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 AADRLPNLS(0.827)S(0.17)PS(0.003)AEGPPGPPSGPAPR;AADRLPNLS(0.541)S(0.418)PS(0.041)AEGPPGPPSGPAPR;AADRLPNLS(0.499)S(0.499)PS(0.002)AEGPPGPPSGPAPR 123.87 4.2199e-09 29576000.0 2893.34 3185.87 3715.2000000000003 3745.3 3368.6 3023.5199999999995 2974.06 3148.46 1609.8600000000001 2545.7599999999998 True False 2960.7491925403974 2812.866859329219 3210.6962461328194 3091.2536629882625 3063.910724774636 2993.1061339365106 2749.7242597705554 3064.9526131605962 2731.8148404776766 2872.53309380231 1.0307102114605469 0.9792287042395352 1.117722978739608 1.076142053735728 1.066623298922208 1.0419744651138556 0.9572471995895458 1.0669860061050105 0.9510124866347954 1.0 11.488107798591596 -7.045633411422978 11.526587999176684 0.9993991033954622 1.0546516671057065 0.2941825455495195 0.04419431839728018 1.6479967645896234 413.92271804960416 0.01700718623941346 0.013213387418983221 9.002571692307637e-08 7.045633411422978 0.05525256371024423 AADRLPNLS(ph)SPSAEGPPGPPSGPAPR ddPTM_A459_Selumetinib_30min_R2 2 AADRLPNLSSPSAEGPPGPPSGPAPR 26 1 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 AADRLPNLS(0.497)S(0.497)PS(0.007)AEGPPGPPSGPAPR;AADRLPNLS(0.544)S(0.366)PS(0.09)AEGPPGPPSGPAPR 103.78 2.0268e-07 65918000.0 22136.9 18776.7 18655.5 24312.0 19869.9 16937.3 12452.2 14971.3 13414.1 21448.3 True False 20906.61971903194 20216.812513393572 17455.225440572613 21000.663659460733 17373.665522840212 19270.259333498834 13031.251973566199 15014.864004367855 16097.294821269617 20829.03184962409 1.0037249868341456 0.9706074031356591 0.8380238489523282 1.0082400282008182 0.8341081644250192 0.9251634676359963 0.6256292691684265 0.7208623095287472 0.7728297185142636 1.0 14.34630816284512 -7.215861076975905 19.86634791156636 0.7565691475137188 0.9268455009147089 0.3227179875935111 0.10434854066233587 42.62866587940004 18580.23087262735 0.03816480056946768 0.02956152887222711 6.083295638873833e-08 7.215861076975905 0.17027635340099 AADRLPNLSS(ph)PSAEGPPGPPSGPAPR ddPTM_A459_Selumetinib_30min_R1 1 AADRLPNLSSPSAEGPPGPPSGPAPR 26 1 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 AADRLPNLS(0.069)S(0.879)PS(0.052)AEGPPGPPSGPAPR 118.98 4.2589e-09 14514000.0 706.9 626.43 629.01 803.39 646.6 818.72 784.11 619.91 344.27 471.16 True False 723.3693946120432 553.0872843805937 543.593896904609 663.0930179980612 588.1151441665022 810.484420138283 724.9639514094174 603.4679730485335 584.2010455140503 531.6379754870441 1.3606428208017873 1.0403457049393425 1.022488840092004 1.2472642071714095 1.1062323823419844 1.524504376113806 1.3636421490493857 1.135110734886244 1.0988700439972374 1.0 9.054300351367814 -8.285419844786508 2.3545788423827876 1.017716265897223 1.22740255451588 0.20403019443552106 0.1491111138836955 0.5305648264457342 5.4255894970092085 0.1502731213502692 0.04296071808968708 5.1829874257275505e-09 8.285419844786508 0.209686288618657 AADS(ph)DDGAVSAPAASDGGVSK ddPTM_A459_Selumetinib_30min_R1 1 AADSDDGAVSAPAASDGGVSK 21 0 Q96GM8 Q96GM8 TOE1 Target of EGR1 protein 1 1 AADS(0.995)DDGAVS(0.001)APAAS(0.005)DGGVSK 60.938 0.018808 4667200.0 1805.0 1319.4 1207.6 998.81 2027.1 1100.5 2404.3 1951.5 208.58 801.79 True False 1847.0529880813947 1164.9240346275806 1043.6145528719837 824.3865834857833 1843.7491629135736 1089.429969174053 2222.941715286966 1899.7398806346298 353.9450259195419 904.7075565959686 2.0416022554637134 1.287624963596741 1.153538008236234 0.9112188546181716 2.037950439864591 1.204179141902071 2.4570831746459088 2.099838634909325 0.39122589762739146 1.0 9.821307711438767 -6.261154246404151 24.999999623816734 1.6165966254000688 1.330222539358867 0.009183003202249629 0.6232134322395447 99.78332750458077 8748814.028092459 0.18859972208789147 0.22839027471845189 5.480822704508771e-07 6.261154246404151 -0.28637408604120185 AADSGS(ph)WER ddPTM_A459_Selumetinib_30min_R2 1 AADSGSWER 9 0 Q674X7-3 Q674X7-3 KAZN Kazrin 1 AADS(0.16)GS(0.84)WER 88.134 0.031598 16143000.0 46556.0 53321.0 39334.0 48174.0 36798.0 39880.0 35958.0 38764.0 29460.0 38903.0 True False 43968.60389843435 57410.549245962204 36803.29326362109 41612.618095214755 32175.1062617061 45373.108005404254 37630.11824942526 38876.79682227434 35352.82318117528 37779.769307867085 1.1638134563537033 1.5196109001652187 0.9741534672621026 1.1014524137538748 0.8516490929182594 1.200989546433148 0.9960388572724644 1.0290374328511003 0.935760694912808 1.0 15.205326271868314 -5.276905824143439 24.992748033538813 1.0159432686929757 1.3417121837713404 0.5536044770902199 0.11867599672498558 473.37952228432266 764949.6856126656 0.028776689050893083 0.060249320453979766 5.285598564561226e-06 5.276905824143439 0.3257689150783647 AADVEPSS(ph)PEPK ddPTM_A459_Selumetinib_30min_R2 1 AADVEPSSPEPK 12 0 F5H3D4;F5GW90;C9IYD2;F8W0I5;E7EUG2;Q92617-4;Q92617-2;Q92617-3;Q92617-5;Q92617-6;Q92617;A8MRT5;C9JG80;A6NJU9;E5RHQ5 F5H3D4 NPIPB4;NPIPB5;NPIPB3;NPIPB11 Nuclear pore complex-interacting protein family member B3;Nuclear pore complex-interacting protein family member B5;Nuclear pore complex-interacting protein family member B4;Putative NPIP-like protein LOC613037;Nuclear pore complex-interacting protein family member B11 1 AADVEPS(0.212)S(0.788)PEPK 99.539 0.015397 0.0 26037.0 28372.0 31013.0 27410.0 31950.0 26141.0 26481.0 27085.0 20225.0 33247.0 True False 24589.96777436926 30548.041169641212 29017.65734440129 23676.71071511264 27936.155363375976 29741.685465628703 27712.418971106017 27163.812865836877 24270.565133715885 32287.072723919955 0.76160412511326 0.9461384570490846 0.8987391824748328 0.7333185921674371 0.865242742885124 0.9211638887161953 0.8583131461953566 0.8413216366224647 0.7517115392048217 1.0 14.978669025886203 AAEAGGAEEQYGFLT(ph)TPTK ddPTM_A459_Selumetinib_30min_R1 4 AAEAGGAEEQYGFLTTPTK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AAEAGGAEEQYGFLT(0.5)T(0.5)PTK;AAEAGGAEEQYGFLT(0.529)T(0.349)PT(0.122)K;AAEAGGAEEQYGFLT(0.5)T(0.5)PTK;AAEAGGAEEQYGFLT(0.5)T(0.5)PTK 270.95 2.3242999999999997e-58 211565500.0 15049.1 16734.1 18592.4 19727.5 16988.1 14652.3 15512.4 14500.0 9034.8 13270.9 True False 15399.714749548872 14774.863792527973 16067.654200742838 16282.462456038471 15451.529354492654 14504.91116522395 14342.287178895105 14115.4128973621 15331.39572431622 14974.349284512718 1.0284062737521482 0.9866781862640893 1.0730118481582953 1.087356929284311 1.0318664978967373 0.9686505162682236 0.9577903457700612 0.9426394849732149 1.0238438701421757 1.0 13.870205691117512 -6.707733269267001 5.182466004405074 0.9736104258772138 1.0436478390336454 0.47744838018220004 0.03279357691961207 0.17515917758974384 9.871503508715332 0.011757227684351942 0.011532715194067487 1.9600481070684766e-07 6.707733269267001 0.07003741315643164 AAEAGGAEEQYGFLT(ph)TPTK ddPTM_A459_Selumetinib_30min_R2 2 AAEAGGAEEQYGFLTTPTK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AAEAGGAEEQYGFLT(0.962)T(0.038)PTK;AAEAGGAEEQYGFLT(0.701)T(0.299)PTK 220.64 6.5178e-19 419660000.0 382380.0 392140.0 418040.0 422520.0 421060.0 366760.0 383210.0 375060.0 308590.0 443840.0 True False 361128.8503884209 422215.87707116513 391143.7615275373 364972.04711234465 368162.6784758397 417277.8608842049 401030.02431620896 376151.36250547465 370316.6227250119 431025.1859651885 0.8378370038394631 0.9795619625468132 0.9074730996325765 0.8467534125530692 0.8541558369760188 0.9681055178940429 0.9304097240122714 0.8726899836796412 0.8591530954177706 1.0 18.717412646780097 -6.742467950379292 24.996784584822827 0.9183859504168915 0.8895073761743951 0.11553220091341942 0.05390192540290481 809.652443020358 1066796.9750245214 0.018437725322093715 0.018408868698742423 1.8093894328007344e-07 6.742467950379292 -0.028878574242496402 AAEAGGAEEQYGFLTT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 4 AAEAGGAEEQYGFLTTPTK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AAEAGGAEEQYGFLT(0.228)T(0.772)PTK;AAEAGGAEEQYGFLT(0.099)T(0.901)PTK;AAEAGGAEEQYGFLT(0.053)T(0.947)PTK;AAEAGGAEEQYGFLT(0.363)T(0.637)PTK 226.79 4.3318999999999996e-23 1313683400.0 28988.699999999997 35754.8 36399.0 37343.3 32114.399999999998 28375.4 29463.6 27644.4 16425.2 25578.7 True False 29664.080307808912 31568.611394044437 31456.215725395272 30821.993675558577 29209.658190257836 28089.969238801823 27241.136930719542 26911.18071033357 27872.364750856555 28861.975302637013 1.0277910640821113 1.0937786157401406 1.0898843684659807 1.067910056479831 1.0120463995958398 0.9732517939004454 0.9438417379641586 0.9324095259645931 0.9657123068880861 1.0 14.81688242025861 -6.529394684187168 1.9741586240636908 0.9555269130531906 1.07424457046373 0.8163602312111211 0.023813159618115448 0.12590640000919906 0.9894169173758219 0.008815593683674733 0.009506954539867626 2.9553254639402223e-07 6.529394684187168 0.11871765741053941 AAEAGGAEEQYGFLTT(ph)PTK ddPTM_A459_Selumetinib_30min_R2 8 AAEAGGAEEQYGFLTTPTK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AAEAGGAEEQYGFLT(0.206)T(0.768)PT(0.026)K;AAEAGGAEEQYGFLT(0.191)T(0.757)PT(0.052)K;AAEAGGAEEQYGFLT(0.102)T(0.898)PTK;AAEAGGAEEQYGFLT(0.09)T(0.91)PT(0.001)K;AAEAGGAEEQYGFLT(0.242)T(0.649)PT(0.109)K;AAEAGGAEEQYGFLT(0.027)T(0.967)PT(0.006)K;AAEAGGAEEQYGFLT(0.012)T(0.987)PT(0.002)K;AAEAGGAEEQYGFLT(0.332)T(0.667)PT(0.001)K 185.63 1.215e-14 473681200.0 336512.0 363032.0 363478.1 409418.0 415591.0 345012.69999999995 340372.7 323542.3 312003.4 394792.0 True False 317810.0102042684 390875.3870681377 340092.31477103283 353654.56211455684 363380.7431493204 392535.0677115378 356200.70498570974 324483.7545276886 374412.7981033776 383393.32916719664 0.8289398537387499 1.0195153575498914 0.8870585085811955 0.9224327478069635 0.9478014235110783 1.0238442817046367 0.9290738202447224 0.846346897147452 0.9765761937399211 1.0 18.548465709561995 -4.733942378200638 24.676949076423583 0.9442032859203797 0.8289391360445364 0.30291399697188126 0.05452804928056395 3542.285756143583 3178795.502945023 0.013538508591516072 1.2464813570085218 1.8452602303981513e-05 4.733942378200638 -0.11526414987584332 AAEDDEDDDVDTK ddPTM_A459_Selumetinib_30min_R1 4 AAEDDEDDDVDTK 13 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ;;; 340.8 3.085899999999998e-138 377644500.0 10141.099999999999 10787.7 11247.8 11925.5 10270.2 9291.1 9652.6 9422.400000000001 6224.039999999999 8683.3 False True 10377.36789885442 9524.671068934333 9720.410539742867 9842.935294359995 9341.262223351083 9197.639969643838 8924.496610647155 9172.487343731354 10561.741294104257 9797.88613750456 1.0591435492531096 0.9721148965464694 0.9920926211353763 1.0045978444965793 0.9533956704798189 0.9387371766280191 0.9108593920565962 0.9361700284126298 1.0779612199896664 1.0 13.258254810635576 -1.5228919458210721 1.0504614453067798 0.9682157593355508 123.3337685012301 0.21173215604045126 0.045255961393950814 3339.7853692761187 3.572586666946158 0.014637444757014671 984946.232359228 0.02999908815280859 1.5228919458210721 122.36555274189455 AAEDDEDDDVDTK ddPTM_A459_Selumetinib_30min_R2 2 AAEDDEDDDVDTK 13 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ; 303.31 4.440399999999998e-73 644980000.0 260590.0 239003.0 248928.0 232068.0 229112.0 170629.0 205574.0 203946.0 151775.0 213782.0 False True 246107.45102442225 257333.76158423 232912.24349231424 200459.93806037089 200328.90227273235 194131.59593415575 215133.5983371531 204539.44909492208 182134.24094782321 207609.55818765782 1.185434106082757 1.23950825689647 1.1218763024474305 0.9655621822535531 0.9649310177311562 0.9350802421085094 1.0362412993658716 0.9852121014102796 0.8772921754555851 1.0 17.663513340254468 -5.615825082339202 3.003978143688222 0.9663364727012995 1.2103106481292945 0.8563238682716262 0.04154715822219108 0.08617971026704832 1.5522912358278012 0.011840693671285768 0.02322020039380646 2.422004343563152e-06 5.615825082339202 0.24397417542799493 AAEDDEDDDVDTKK ddPTM_A459_Selumetinib_30min_R1 3 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ;; 167.22 0.00029557 37802300.0 10820.099999999999 13186.2 15281.900000000001 15951.2 10224.599999999999 12685.599999999999 11863.900000000001 11744.3 7875.900000000001 11597.099999999999 False True 11072.18727775041 11642.353573901926 13206.701917468 13165.622361108142 9299.786735299742 12557.994381603237 10968.996471319313 11432.803013137216 13364.827067023294 13085.700750320042 0.8461287239416363 0.8897004291968991 1.0092468236479426 1.0061075529933807 0.7106831275407466 0.9596730523809435 0.8382429554680929 0.8736867234914875 1.02133063578551 1.0 13.675703563541207 -8.264290162505496 24.685382855549715 1.010665336491588 0.8938020691953718 0.24465585833949843 0.08355839888288094 322.6309239660145 2793619.2619095976 0.07060462503684904 0.0213786051079086 5.441389791314567e-09 8.264290162505496 -0.11686326729621632 AAEDDEDDDVDTKK ddPTM_A459_Selumetinib_30min_R2 5 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ;;;; 275.95 3.9155999999999996e-44 135245600.0 439996.0 393260.0 395420.0 389240.0 334659.0 281198.0 355457.0 306160.0 220528.0 350697.0 False True 415542.78376354364 423421.7774697975 369979.10770074435 336224.8405235469 292616.1445305802 319930.4720387081 371986.4548246833 307050.87491248356 264639.76206714945 340571.46638976573 1.220133877240254 1.243268503842345 1.0863479305025605 0.9872372576825201 0.8591916041366096 0.9393930602294347 1.0922419860005677 0.901575455417279 0.7770461949512925 1.0 18.37759804326894 -5.56685514910468 2.012425739697097 0.931879383218404 1.237067731978637 0.6954709183316338 0.07911357428665228 0.1952644443221125 1.5660095857540546 0.024606787469064258 0.06027772143094537 2.7110957169664204e-06 5.56685514910468 0.30518834876023293 AAEDSPYWVS(ph)PAYSK ddPTM_A459_Selumetinib_30min_R2 1 AAEDSPYWVSPAYSK 15 0 Q9NW82 Q9NW82 WDR70 WD repeat-containing protein 70 1 AAEDS(0.001)PY(0.001)WVS(0.997)PAYS(0.001)K 94.007 0.011887 3030900.0 14592.0 13314.0 12513.0 14466.0 13533.0 13100.0 12514.0 13129.0 11154.0 14147.0 True False 13781.035056404195 14335.140988742538 11707.927203124282 12495.705844758098 11832.863553444982 14904.406090040025 13095.925796020569 13167.203216377044 13385.111668799354 13738.53935167971 1.0030931748737386 1.043425405117021 0.852195921518603 0.909536707279609 0.8612897812894691 1.084861040065207 0.9532254820392844 0.9584136187495934 0.974274726458665 1.0 13.745941008006472 -6.745882647601422 24.990172428287014 0.988997770886289 0.9340989794315645 0.17878871197255752 0.06408409969919529 514.8348175577153 827023.839632492 0.022587535327937294 0.022511512867570527 1.7952186543034737e-07 6.745882647601422 -0.05489879145472454 AAEEAFVNDIDESS(ph)PGTEWER ddPTM_A459_Selumetinib_30min_R1 2 AAEEAFVNDIDESSPGTEWER 21 0 P09496-2;P09496-5 P09496-2 CLTA Clathrin light chain A 1 AAEEAFVNDIDES(0.09)S(0.868)PGT(0.043)EWER;AAEEAFVNDIDES(0.017)S(0.983)PGTEWER 263.5 4.5888999999999985e-49 10401200.0 4517.0 5076.6 5607.4 5717.799999999999 5874.799999999999 4768.4 4692.5 4249.2 3026.6099999999997 3962.95 True False 4622.237311448008 4482.229311952689 4845.945879243425 4719.293566399026 5343.425377280179 4720.434225360794 4338.540947046578 4136.497412653175 5135.936115151715 4471.6332349019 1.033679881294963 1.002369621231027 1.0837082615407605 1.055384759546935 1.194960565095944 1.0556398473195334 0.9702363139229504 0.9250529270529323 1.1485593395864426 1.0 12.126586147286988 -7.016701067363322 24.381653359514697 1.0058910438721316 1.0751186026823853 0.1497459062562111 0.07073181221404505 989.17582870217 1444081.4806738251 0.027149034819329104 0.021583094419232205 9.622744011126297e-08 7.016701067363322 0.06922755881025378 AAEEAFVNDIDESSPGTEWER ddPTM_A459_Selumetinib_30min_R2 3 AAEEAFVNDIDESSPGTEWER 21 0 P09496-2;P09496-5 P09496-2 CLTA Clathrin light chain A 0 ;; 203.52 7.327099999999999e-16 8378700.0 26420.9 26508.6 28959.699999999997 30349.3 33206.1 26210.899999999998 25564.5 27072.8 24180.600000000002 27358.1 False True 24952.5321492427 28541.724381416596 27096.46443093731 26215.672984537316 29034.4528516995 29821.213556139694 26753.299905095722 27151.577365856676 29017.39566241435 26568.20056811965 0.9391878868599155 1.0742814255800621 1.0198833135674061 0.9867312209316371 1.0928272231781935 1.1224400944911368 1.006966950452722 1.0219577082851838 1.0921852079524572 1.0 14.697412898707894 -4.752430633244746 24.991180255190887 1.0469570610041203 0.9391876785205556 0.34776198429646565 0.04402641467997649 420.7546270432985 1167131.5014234341 0.011232369979474924 0.1338351577406508 1.7683546418337982e-05 4.752430633244746 -0.10776938248356471 AAEEEDEADPKR ddPTM_A459_Selumetinib_30min_R1 4 AAEEEDEADPKR 12 1 P20962 P20962 PTMS Parathymosin 0 ;;; 129.0 0.0032082 78175000.0 19030.7 20072.0 22840.0 24590.199999999997 20002.9 19146.4 20135.3 19481.7 11645.300000000001 17394.0 False True 19474.078282703922 17721.960908780355 19738.453451139532 20295.983185222536 18193.641226798827 18953.804599540283 18616.47810997698 18964.982030519932 19761.223560939892 19626.68933190772 0.992224310141003 0.9029521285573726 1.0056944967814878 1.0341012099389948 0.9269847257031198 0.9657158310814291 0.9485286996269712 0.9662853326815526 1.0068546572861605 1.0 14.260529216273422 -8.258703512233078 23.27841246967985 1.0034273350287655 0.967047907773211 0.13746794407142737 0.03564504634938007 177.38927685603016 1509426.2679067468 0.02707561662360944 0.009201738089706181 5.5118385476695185e-09 8.258703512233078 -0.03637942725555443 AAEEEDEADPKR ddPTM_A459_Selumetinib_30min_R2 3 AAEEEDEADPKR 12 1 P20962 P20962 PTMS Parathymosin 0 ;; 110.93 0.0094858 66042000.0 257885.0 245068.0 233814.0 255598.0 252649.0 173877.0 194801.0 198258.0 135441.0 211123.0 False True 243552.78409544926 263863.9275821806 218770.66179743456 220785.1114688571 220908.97390928242 197826.97845174719 203859.63249085852 198834.89795662122 162532.98453773107 205027.33042656968 1.187903991086093 1.2869695324676882 1.067031704223389 1.0768569780892263 1.0774611045740594 0.9648810138636552 0.9943046718050628 0.969797038974927 0.7927381398351772 1.0 17.645456710229773 -5.818090180387165 0.529993168154017 0.9157941882615296 1.299837855302421 0.7108756888314682 0.06838083842346082 0.863566279428595 0.3888980414408018 0.04831169266442249 0.18328335220669956 1.5202318238349646e-06 5.818090180387165 0.38404366704089143 AAEELHRVDLVLPEDTT(ph)EYFVR ddPTM_A459_Selumetinib_30min_R1 1 AAEELHRVDLVLPEDTTEYFVR 22 1 B0QY93;Q09327 B0QY93 MGAT3 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase 1 AAEELHRVDLVLPEDT(0.282)T(0.387)EY(0.33)FVR 60.062 0.021975 26788000.0 3011.5 3282.1 2108.7 2874.9 6166.7 2595.8 4811.5 3188.3 304.44 1022.8 True False 3081.6620906410626 2897.8302061931045 1822.3501222599798 2372.8526835567127 5608.923073819315 2569.6886087978232 4448.564681239128 3103.735926942039 516.6124445821524 1154.0863429156723 2.670217969008785 2.510930160452341 1.579041406603957 2.0560443316242365 4.860054976171876 2.226599963314519 3.854620331092662 2.6893446456534535 0.44763760333302954 1.0 10.172535447845155 -8.25200489444461 17.884827480269816 0.7238159005292727 2.8142670531750027 0.4645240611992205 0.8941219865811687 11.625151436056324 22046.193325236785 0.6530051743703267 0.2343379126351569 5.5975129313234746e-09 8.25200489444461 2.09045115264573 AAEEQGDDQDS(ph)EK ddPTM_A459_Selumetinib_30min_R2 1 AAEEQGDDQDSEK 13 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 AAEEQGDDQDS(1)EK 171.15 0.00020919 5633700.0 11362.0 5474.8 8550.6 8810.7 8728.9 9060.7 24893.0 45515.0 13007.0 12632.0 True False 10730.545525689724 5894.699555743402 8000.463705189369 7610.667460694742 7632.297544643899 10308.729180154629 26050.573824543713 45647.4411145861 15608.76344594525 12267.28133812244 0.8747289012067346 0.4805220809132931 0.6521790350015624 0.6204037594738645 0.6221669931809075 0.8403434221499989 2.1235816727857704 3.7210723269816715 1.2723897834998408 1.0 13.58252793542937 -7.250489628850229 4.448861890104159 2.2717013295878905 0.6526593794653401 0.4641576400229731 0.693385574922608 0.15083559773019903 7.84482664492834 0.2727122699983697 0.19566467147039018 5.6170769203066094e-08 7.250489628850229 -1.6190419501225504 AAEEQGDDQDS(ph)EKSKPAGSDGER ddPTM_A459_Selumetinib_30min_R2 2 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 AAEEQGDDQDS(0.935)EKS(0.062)KPAGS(0.003)DGER;AAEEQGDDQDS(0.997)EKS(0.003)KPAGSDGER 93.255 0.00012259 6705700.0 17159.1 15202.8 13526.4 14392.5 11559.599999999999 7765.400000000001 9992.8 10178.4 7696.1 13146.6 True False 16205.465915319715 16368.805875293314 12656.12615043078 12432.216671552664 10107.379703864815 8835.013362717315 10457.485000357556 10208.017458875176 9235.535047000785 12767.023499031067 1.2693221655423133 1.2821160606883506 0.9913137663913046 0.973775655108349 0.7916786324261014 0.6920182580840267 0.8191012573252653 0.7995612649769068 0.7233898369264928 1.0 13.640134594196928 -5.528274013491442 1.241099828183203 0.7906088017815313 1.3227418666031943 0.8113590292953181 0.08657097382648503 0.21488307193527184 0.5913639027969699 0.027786636303504166 0.10424394423211396 2.962961350646254e-06 5.528274013491442 0.532133064821663 AAEEQGDDQDSEKS(ph)KPAGSDGER ddPTM_A459_Selumetinib_30min_R1 1 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 AAEEQGDDQDS(0.398)EKS(0.6)KPAGS(0.002)DGER 74.703 0.0010883 6547300.0 1185.8 1332.0 1090.9 1369.1 1175.1 1327.6 1325.9 1204.4 891.0 1283.4 True False 1213.426832834857 1176.0488207699993 942.7617718847688 1130.0123861899528 1068.8124124807548 1314.2455493643538 1225.8862955117859 1172.4553995574418 1511.9619239347583 1448.1368913746321 0.8379227406347071 0.8121116365274312 0.6510170257384024 0.7803215241048779 0.7380603441890037 0.9075423443682986 0.8465265285439441 0.8096302266317503 1.0440738944917982 1.0 10.499982270489706 -7.921192052818095 0.7689970232005607 1.0190240537268591 0.766625784539706 0.5917056884125143 0.07090908697008792 0.45604695699337494 0.5287241628408639 0.06753419695264525 0.029425865275177248 1.1989689802870888e-08 7.921192052818095 -0.25239826918715313 AAEEQGDDQDSEKS(ph)KPAGSDGER ddPTM_A459_Selumetinib_30min_R2 1 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 AAEEQGDDQDS(0.155)EKS(0.835)KPAGS(0.009)DGER 52.273 0.036595 3641300.0 3643.8 2353.3 3357.0 3122.8 1145.5 906.05 2852.6 3032.0 806.07 1999.0 True False 3441.2921832871157 2533.7905429478624 3141.0142748252388 2697.4692528695277 1001.5920491000685 1030.8501631970046 2985.251552319664 3040.8226180253805 967.3065234775956 1941.283675974252 1.772688981974811 1.3052139542028833 1.6180089049833948 1.3895286331688628 0.5159431676554999 0.5310146971073985 1.5377719337291014 1.5663978715008327 0.4982819025623051 1.0 10.92279523631376 -6.020586665438751 22.230601906557187 0.9767673150397671 1.5333741902101152 0.3660129208994024 0.37675249345515904 232.50426548643642 251072.0152355788 0.11802379864588544 0.15469863186283778 9.537034079991995e-07 6.020586665438751 0.5566068751703481 AAEMMAS(ph)LLK ddPTM_A459_Selumetinib_30min_R1 1 AAEMMASLLK 10 0 P33176 P33176 KIF5B Kinesin-1 heavy chain 1 AAEMMAS(1)LLK 93.162 0.027706 0.0 557.75 686.0 754.56 685.01 694.71 775.92 612.97 656.07 373.28 706.04 True False 570.7444898074225 605.6828010872524 652.0948965013938 565.3858627302457 631.873603161012 768.1149492789916 566.7331793950217 638.6688923843002 633.4288967074821 796.667111411988 0.7164152776381753 0.7602708740087928 0.8185287018383891 0.7096889712544721 0.7931463394304039 0.9641604859495312 0.7113801627765974 0.8016759864133758 0.7950985896541058 1.0 9.637833207542382 -14.522878745280183 0.20205874609476226 1.9603888812036978 0.7549348858186292 0.4715400550389601 0.06951620736842222 133.03301836546004 1.3149541185510352 51.73060171261317 0.16586897428577604 3.0000000000010687e-15 14.522878745280183 -1.2054539953850685 AAEPHFGT(ph)LPK ddPTM_A459_Selumetinib_30min_R1 1 AAEPHFGTLPK 11 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 AAEPHFGT(1)LPK 101.2 0.021022 6100200.0 7500.2 8856.1 7536.4 8954.5 7703.5 7735.1 7516.4 6240.8 4955.1 5608.7 True False 7674.940067151289 7819.223694910806 6512.998274481961 7390.7646717828675 7006.719785163392 7657.291916908867 6949.431896511641 6075.273711024646 8408.442793814947 6328.631278364423 1.2127330112262138 1.2355315629845973 1.0291322069509452 1.167829874533778 1.1071461548276855 1.2099443908332457 1.0980939781196508 0.9599664514812348 1.3286352805164583 1.0 12.627677799887012 -14.522878745280336 0.09345043204864928 0.6266356021681851 1.2352872869008595 0.1312924970533661 0.1031776649691309 429.22334793379633 2.757221585055347 33.294152379840526 2.102519204039647 3.0000000000000132e-15 14.522878745280336 0.6086516847326744 AAEPHFGT(ph)LPK ddPTM_A459_Selumetinib_30min_R2 2 AAEPHFGTLPK 11 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 AAEPHFGT(1)LPK;AAEPHFGT(1)LPK 126.32 0.0043129 5788300.0 122346.0 83714.0 104112.0 102373.0 98768.0 97952.0 59703.0 72011.0 68674.0 91150.0 True False 115546.49910984283 90134.59461706418 97413.54726857482 88429.6207967248 86359.8808428769 111443.99888027472 62479.30779925012 72220.54008793725 82410.71891188172 88518.26266385849 1.3053407922003852 1.0182598698230623 1.100490953358354 0.9989986036274763 0.9756165365651392 1.25899442133738 0.7058352244949795 0.8158829366340974 0.9310024443750131 1.0 16.433687515382992 -7.264704868374564 24.99998064263376 0.847837066290834 1.093930430729314 0.4853731234149802 0.12327831831147132 253.23996717406965 1938745.8888011375 0.04921975661709008 0.034756445002583465 5.4361963124152126e-08 7.264704868374564 0.24609336443848007 AAES(ph)AEIEPR ddPTM_A459_Selumetinib_30min_R2 2 AAESAEIEPR 10 0 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 AAES(1)AEIEPR;AAES(1)AEIEPR 113.38 0.005492 0.0 36665.0 39718.0 46418.0 44584.0 50216.0 37249.0 32125.0 39379.0 39402.0 36627.0 True False 34627.306081624156 42764.24288650114 43431.516416097096 38511.58228831017 43907.41714326411 42379.71163724434 33618.87615447988 39493.586370455625 47283.50098386517 35569.48334162527 0.973511640555697 1.2022733778777208 1.2210330973593664 1.0827141321797582 1.234412564319745 1.191462671251381 0.9451606544742053 1.1103221823927412 1.3293277422596559 1.0 15.118352398484257 AAES(ph)ETPGKSPEK ddPTM_A459_Selumetinib_30min_R2 1 AAESETPGKSPEK 13 1 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AAES(0.866)ET(0.13)PGKS(0.004)PEK 136.01 0.0053006 210580000.0 45264.0 36357.0 34549.0 35249.0 35596.0 28254.0 48858.0 43027.0 27698.0 31345.0 True False 42748.40808614853 39145.46499381949 32326.154954107005 30448.025392083364 31124.11224772244 32145.73203572449 51129.99381029031 43152.2014464967 33238.37394678181 30439.98840590944 1.4043503406147686 1.2859881702918132 1.061963445026523 1.0002640272416254 1.0224745105908184 1.0560362772504837 1.6796982025250784 1.4176155677549267 1.091931228867653 1.0 14.893680188892217 AAES(ph)PDQKDTDGGPKEEESPV ddPTM_A459_Selumetinib_30min_R1 1 AAESPDQKDTDGGPKEEESPV 21 2 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 AAES(0.862)PDQKDT(0.137)DGGPKEEESPV 65.21300000000001 0.011589 5371100.0 1088.5 916.79 1422.6 1138.1 1593.3 925.24 1281.7 1503.9 495.72 977.23 True False 1113.8599321476995 809.4518005958922 1229.4187337824467 939.3521997829121 1449.186296319963 915.9329256507042 1185.02033709741 1464.0116866443348 841.2006340437017 1102.6669895262833 1.0101507914245487 0.734085456701339 1.114950157627025 0.8518911046629474 1.3142556275694333 0.8306523495767277 1.074685601685153 1.327700657179634 0.7628782234653546 1.0 10.106781440869616 -5.275789845250196 24.92854563509378 1.0439366609488465 0.8721181048444406 0.10324549438485109 0.18999599724819233 1382.7878801240888 2402074.5809520776 0.046840340221819404 0.09822798156967331 5.299198096278966e-06 5.275789845250196 -0.17181855610440588 AAESETPGKS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 4 AAESETPGKSPEK 13 1 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AAES(0.169)ET(0.054)PGKS(0.777)PEK;AAESET(0.082)PGKS(0.918)PEK;AAES(0.008)ET(0.183)PGKS(0.809)PEK;AAESET(0.002)PGKS(0.998)PEK 194.23 0.00091486 477176000.0 19328.059999999998 24695.100000000002 16490.98 15207.120000000003 12909.19 16645.48 16363.470000000001 16202.98 10046.650000000001 17650.98 True False 19778.366192142093 21803.786211559494 14251.595494469042 12551.48196499667 11741.556043802608 16478.041584086604 15129.160283594725 15773.22433570346 17048.431271716203 19916.655218104894 0.9930566139520711 1.094751401416998 0.7155616913784737 0.630200293550644 0.5895345335460318 0.8273498438185305 0.7596235471226023 0.7919615097501452 0.8559886730488069 1.0 14.281687762626882 -5.262938495824022 24.998384188715654 0.7539046381454833 1.043904023702926 0.4788043363399118 0.1126147035294478 98.17549814539488 1637150.5403057288 0.029579220928113378 0.06736136350829484 5.458351560278942e-06 5.262938495824022 0.28999938555744276 AAESETPGKS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 AAESETPGKSPEK 13 1 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AAES(0.209)ET(0.241)PGKS(0.549)PEK;AAES(0.247)ET(0.196)PGKS(0.557)PEK 158.29 0.001731 30484100.0 91888.0 72261.0 66259.0 73515.0 60997.0 65968.0 89339.0 82396.0 56098.0 63896.0 True False 86781.23281680838 77803.18634426336 61995.96807734458 63502.13017955141 53334.011539901265 75054.49320211905 93493.44052187001 82635.75871860796 67319.1675090825 62051.15645825456 1.3985433595454613 1.2538555408972292 0.9991105986727724 1.023383508126444 0.8595168016857537 1.2095583303529982 1.5067155208423635 1.3317359971236291 1.0848978705879888 1.0 15.92117047791542 -6.990023249902896 24.98273886395317 1.27271845900806 1.0974327095919902 0.0748883874397891 0.1883560067292273 412.8423475163552 1033791.9217503475 0.06978209804040769 0.06147654505311533 1.023238211879735e-07 6.990023249902896 -0.17528574941606978 AAESPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AAESPSPR 8 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 AAES(0.013)PS(0.987)PR 81.95 0.042493 5223900.0 23360.0 17447.0 18199.0 20960.0 16174.0 19793.0 35717.0 77252.0 25992.0 43291.0 True False 22061.744717489175 18785.128799052953 17028.096153573006 18105.211841983237 14142.077522605421 22519.306087035275 37377.91127189283 77476.79053024284 31191.126277159103 42041.076346473914 0.5247664102524707 0.44682796996534335 0.4050347334887203 0.4306552880038659 0.3363871420906556 0.5356500842520419 0.8890807400802383 1.8428831339077028 0.7419202596076058 1.0 15.359511985572707 -7.387820109298101 3.4007800371087797 1.2381592222866658 0.4365183155131148 0.6098063372448165 0.2683052613866614 0.14711085139292857 3.1444256510081248 0.11512717977014077 0.07312639710996909 4.094302161949669e-08 7.387820109298101 -0.8016409067735509 AAET(ph)SDDDLIPFGDRPTVSR ddPTM_A459_Selumetinib_30min_R2 1 AAETSDDDLIPFGDRPTVSR 20 1 Q5TC82-2;Q5TC82 Q5TC82-2 RC3H1 Roquin-1 1 AAET(0.5)S(0.5)DDDLIPFGDRPTVSR 88.76799999999999 0.0026752 2624400.0 5223.9 5066.7 4464.6 6173.1 6973.0 4554.0 2886.3 2694.6 2918.7 5212.6 True False 4933.576550928587 5455.299597991726 4177.352496688942 5332.313130808528 6096.989400589069 5181.272162903989 3020.5186690949477 2702.440839884956 3502.521555291794 5062.09869403871 0.9746108974008201 1.0776754717200716 0.8252214642927302 1.0533799226569862 1.2044390615633551 1.0235423045002305 0.5966929630692518 0.5338577936197564 0.6919109576856879 1.0 12.305519920125734 -7.253883492331325 24.319747818084547 0.6667702411394163 1.0289692645236406 0.531429696995382 0.14577584092197154 280.18057095492185 901804.9249725749 0.056104091681300684 0.04256200170985434 5.5733524454754495e-08 7.253883492331325 0.3621990233842243 AAETS(ph)DDDLIPFGDRPTVSR ddPTM_A459_Selumetinib_30min_R2 1 AAETSDDDLIPFGDRPTVSR 20 1 Q5TC82-2;Q5TC82 Q5TC82-2 RC3H1 Roquin-1 1 AAET(0.452)S(0.548)DDDLIPFGDRPTVSR 86.35700000000001 0.0012553 3261500.0 9803.8 8785.6 12299.0 14889.0 12023.0 8543.6 9822.2 8967.0 9349.2 9922.1 True False 9258.94404372091 9459.427269843505 11507.6957301387 12861.09251504239 10512.563253016258 9720.403348921065 10278.95176232006 8993.092485433233 11219.301238474001 9635.623192288213 0.9609076505950571 0.9817141124213197 1.1942866071546658 1.3347442358824964 1.091010206940211 1.0087986168554937 1.0667656421586442 0.9333171613259822 1.1643565771078794 1.0 13.234162261753797 -6.53572116960935 16.260184867623902 1.0344191707348938 1.1260428906714868 0.10917531236772804 0.11238622389574092 8.707837030101308 11018.56192022452 0.0400288855037433 0.040182301234737004 2.9125864878504665e-07 6.53572116960935 0.09162371993659302 AAEVVASAMRPGPES(ph)PSTR ddPTM_A459_Selumetinib_30min_R2 2 AAEVVASAMRPGPESPSTR 19 1 A0A1B0GV70;Q96N21-2 A0A1B0GV70 ENTHD2 AP-4 complex accessory subunit tepsin 1 AAEVVASAMRPGPES(0.714)PS(0.262)T(0.024)R;AAEVVAS(0.002)AMRPGPES(0.568)PS(0.396)T(0.034)R 84.37100000000002 0.0022178 29992000.0 48569.0 43488.0 51461.0 47453.0 53782.0 40422.0 36204.0 40914.0 36165.0 40586.0 True False 45869.72941711183 46823.38976404051 48150.05528650038 40989.819539009135 47025.42434281962 45989.763585618144 37887.557736865034 41033.05296632269 43399.010534528294 39414.17672490796 1.1637875817440138 1.187983453031261 1.2216430555575133 1.0399765501915317 1.1931093898277902 1.1668330384420973 0.9612672618104396 1.0410734506193982 1.1011015360648673 1.0 15.266427019688134 -7.243226955352817 24.685110832681136 1.029283351662604 1.1619414500152354 0.5906385397862836 0.05558529074723698 511.3678292090288 693108.7659522129 0.02152669447049425 0.016642510423010994 5.711800690931607e-08 7.243226955352817 0.13265809835263132 AAFDDAIAELDT(ph)LSEESYK ddPTM_A459_Selumetinib_30min_R1 1 AAFDDAIAELDTLSEESYK 19 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 AAFDDAIAELDT(0.783)LS(0.184)EES(0.033)YK 122.77 0.00056685 2118400.0 530.23 1124.2 879.59 716.18 752.27 909.48 872.09 737.7 428.67 642.23 True False 542.583327352021 992.5781413735989 760.1465092420239 591.1126073636109 684.227311324056 900.3314569417695 806.3075491763134 718.1337996126907 727.4216811819445 724.6664763499534 0.7487352389818548 1.3697034066941804 1.048960499829906 0.8157029842762491 0.9441961697613169 1.2424080405604199 1.1126602036809747 0.9909852643244008 1.0038020315854386 1.0 9.501173345416069 AAFDDAIAELDTLSEESYK ddPTM_A459_Selumetinib_30min_R1 2 AAFDDAIAELDTLSEESYK 19 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 ; 244.44 3.4963999999999996e-29 16492800.0 2463.2 2722.2 2132.58 2450.5 2884.1 2164.96 2337.5 2546.6000000000004 2062.87 2849.2 False True 2520.5877674471426 2403.4835584835537 1842.9873494234303 2022.5661765820448 2623.2336642292107 2143.182468026403 2161.1804930679523 2479.0558954773996 3500.5397239363547 3214.922573558209 0.7840275184784338 0.7476023149831035 0.5732602596969079 0.6291181607971078 0.8159554714643938 0.6666357957275386 0.6722340720871555 0.7711090512309391 1.0888410665710155 1.0 11.650568277553198 -8.159112907150043 4.014271607310281 1.0440744757413944 0.6975390265761069 0.783920399224401 0.07140000534345514 0.10345146945425136 2.822231217317979 0.057188832409356224 0.019324847413823485 6.93245553771927e-09 8.159112907150043 -0.34653544916528756 AAFTTPDHAPLS(ph)PQSSVASSGSEQTEEQGSSR ddPTM_A459_Selumetinib_30min_R1 4 AAFTTPDHAPLSPQSSVASSGSEQTEEQGSSR 32 0 M0QZ22;Q5PRF9;A0A087WZT0;M0R0X3 M0QZ22 SAMD4B Protein Smaug homolog 2 1 AAFTTPDHAPLS(0.991)PQS(0.008)SVASSGSEQTEEQGSSR;AAFTTPDHAPLS(0.999)PQS(0.001)SVASSGSEQTEEQGSSR;AAFTTPDHAPLS(1)PQSSVASSGSEQTEEQGSSR;AAFTTPDHAPLS(0.999)PQS(0.001)SVASSGSEQTEEQGSSR 167.5 1.3235999999999999e-28 136757700.0 5460.53 6224.540000000001 6847.71 7212.0 7976.299999999999 5773.45 8058.41 6492.049999999999 3022.0 5302.5 True False 5587.749724658227 5495.767963089864 5917.828593778573 5952.5595860068215 7254.845073330145 5715.374334873181 7450.557645836891 6319.859744849624 5128.113281852789 5983.127525723849 0.9339178716539576 0.9185443464912568 0.9890861540783595 0.9948909764022906 1.2125506337845342 0.9552486237842182 1.24526138107603 1.056280301176605 0.8570957680251653 1.0 12.546684097908786 -5.722446788068927 2.3064358329425994 1.0628497704542927 0.931630575863996 0.16203151989849784 0.10808653178893858 0.49007987944546993 5.304690750042498 0.031944669721473876 0.06202470930517128 1.8947556550700124e-06 5.722446788068927 -0.13121919459029674 AAFTTPDHAPLS(ph)PQSSVASSGSEQTEEQGSSR ddPTM_A459_Selumetinib_30min_R2 4 AAFTTPDHAPLSPQSSVASSGSEQTEEQGSSR 32 0 M0QZ22;Q5PRF9;A0A087WZT0;M0R0X3 M0QZ22 SAMD4B Protein Smaug homolog 2 1 AAFTTPDHAPLS(0.967)PQS(0.013)S(0.017)VAS(0.002)S(0.001)GSEQTEEQGSSR;AAFTTPDHAPLS(0.748)PQS(0.184)S(0.067)VAS(0.001)SGSEQTEEQGSSR;AAFTTPDHAPLS(0.922)PQS(0.036)S(0.036)VAS(0.003)S(0.002)GS(0.001)EQTEEQGSSR;AAFTTPDHAPLS(0.865)PQS(0.095)S(0.039)VAS(0.001)SGSEQTEEQGSSR 99.29 4.5941e-09 190491000.0 273249.0 247923.0 295672.0 334462.0 325672.0 216761.0 232784.0 264394.0 231264.0 292395.0 True False 258062.9144824142 266937.8969019091 276648.78542333294 288907.6986208684 284758.1718153799 246617.86018955475 243608.9172527455 265163.34276721696 277523.26205605274 283952.7966165539 0.9088232887908441 0.9400784217750758 0.9742773753938961 1.0174497383486083 1.0028362995836717 0.8685171025893583 0.8579204718371264 0.9338289530047842 0.9773570303335187 1.0 18.115291595197526 -6.748798306382754 24.99986838275095 0.9190387471822133 0.9701222663834778 0.13655502586538437 0.049446887597034 406.91304607838435 804738.2763390486 0.01747492962342801 0.01736308645079612 1.7832067261867485e-07 6.748798306382754 0.051083519201264416 AAGARPLTS(ph)PESLSR ddPTM_A459_Selumetinib_30min_R2 1 AAGARPLTSPESLSR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 AAGARPLT(0.037)S(0.843)PES(0.118)LS(0.002)R 139.0 0.0018765 14556000.0 29658.0 26421.0 32109.0 31465.0 29330.0 22275.0 20396.0 20415.0 16185.0 32900.0 True False 28009.72709038074 28447.405743094972 30043.141897635876 27179.412719847453 25645.30318647315 25343.179057682544 21344.45441390727 20474.40427011482 19422.45224668438 31950.091515534223 0.8766712632657823 0.890370086397523 0.9403147369086194 0.8506834074835982 0.8026675971805693 0.7932114700003479 0.6680561275866624 0.6408245891928075 0.6078997375403802 1.0 14.9635324430791 -6.620008748162679 1.4060441715408418 0.7036529393906266 0.8977060683968716 0.2991613110969813 0.10439507573568026 0.42122090261499073 1.7309432352794136 0.04368186399971935 0.044653347845536956 2.398784598881583e-07 6.620008748162679 0.19405312900624505 AAGGAPS(ph)PPPPVR ddPTM_A459_Selumetinib_30min_R1 3 AAGGAPSPPPPVR 13 0 Q4KMP7;Q4KMP7-2 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 AAGGAPS(1)PPPPVR;AAGGAPS(1)PPPPVR;AAGGAPS(1)PPPPVR 122.46 0.0026431 163467000.0 6136.0 8119.6 6931.900000000001 7739.0 7687.099999999999 6459.6 7284.5 6482.700000000001 3895.6800000000003 5880.5 True False 6278.9568614224 7168.953457300369 5990.586054201144 6387.5289290220135 6991.803162267736 6394.622288847533 6735.024300215404 6310.757737222709 6610.684430790298 6635.319455920627 0.9462930764877872 1.0804232569245158 0.9028331030627028 0.9626558256094946 1.0537251761147721 0.9637248562526523 1.0150263819183283 0.9510857433686459 0.996287288759195 1.0 12.69595021014872 -5.248161690392178 24.99491717306521 0.9815083216154615 1.0133581395818771 0.06713389194300512 0.04866368463109745 2347.966054515759 4419969.375754833 0.011901949045663012 0.031103011176341996 5.647266845995315e-06 5.248161690392178 0.03184981796641562 AAGGAPS(ph)PPPPVR ddPTM_A459_Selumetinib_30min_R2 5 AAGGAPSPPPPVR 13 0 Q4KMP7;Q4KMP7-2 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 AAGGAPS(1)PPPPVR;AAGGAPS(1)PPPPVR;AAGGAPS(1)PPPPVR;AAGGAPS(1)PPPPVR;AAGGAPS(1)PPPPVR 175.88 3.9105e-07 186720000.0 303022.0 252948.0 307439.0 337721.0 331532.0 229151.0 271209.0 287217.0 275229.0 268878.0 True False 286181.25033317646 272348.2982439875 287658.70945427375 291722.8171987793 289881.98622631497 260714.4702243328 283820.75589043845 288052.75391866575 330282.49054078985 261114.79351105783 1.095997842500858 1.0430213262982126 1.1016561167840988 1.1172205652393468 1.1101706737042414 0.9984668686084687 1.0869577785083213 1.1031652019611333 1.264893827345722 1.0 17.994324670580276 -8.011898773652383 24.362602085703877 1.1496411015330905 1.0793261316348286 0.07835470893779628 0.06837696942273788 721.5466020158168 1477349.711129475 0.039350673772431954 0.016670021883423914 9.729739803422549e-09 8.011898773652383 -0.07031496989826191 AAGHPGDPESQQR ddPTM_A459_Selumetinib_30min_R1 1 AAGHPGDPESQQR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 92.792 0.036704 0.0 1851.9 569.66 705.83 657.47 835.64 434.74 649.61 786.48 743.53 889.66 False True 1895.0456668298793 502.96394237225064 609.9821628466642 542.6552067404191 760.0565095442249 430.3669103123373 600.6093946959883 765.6199955529199 1261.7161047174084 1003.8565270222505 1.8877654483665829 0.5010317000818808 0.6076387874431223 0.5405704820688895 0.7571365918183428 0.4287135648646315 0.5983020267623121 0.7626787045196449 1.2568689556266066 1.0 9.971337376117777 -10.828886160858756 13.725796314402649 0.999940286493643 0.7711232774966689 0.007105912627824562 0.42226157408766296 8.230983664269753e-10 0.0 0.3987715402586719 0.09671630476333823 1.482906740111264e-11 10.828886160858756 -0.2288170089969741 AAGISLIVPGKS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 AAGISLIVPGKSPTR 15 1 P47736-4;F2Z357;J3KPC5;P47736;P47736-3 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 AAGISLIVPGKS(0.955)PT(0.045)R;AAGISLIVPGKS(0.746)PT(0.254)R 110.37 0.0046806 108536000.0 5307.5 6283.099999999999 6938.0 7193.0 6806.9 5678.700000000001 6322.1 6288.2 3170.8199999999997 5242.8 True False 5431.154423402768 5547.471731066057 5995.857707706043 5936.877579332647 6191.217096855802 5621.577433847062 5845.218907048087 6121.416509047749 5380.649952470041 5915.764449196603 0.918081588617064 0.9377438501324098 1.0135389532827523 1.0035689605827547 1.0465624772630369 0.9502706678273011 0.9880749913634415 1.0347633956046163 0.9095443198724328 1.0 12.53034889376888 -5.1390648299238 4.624400156199589 0.9949553584822894 0.9227081107275469 0.3297667950048261 0.03755402533019383 0.23750040112450135 7.753416176902842 0.00935101784852889 0.02730276444254026 7.259975750297736e-06 5.1390648299238 -0.07224724775474256 AAGISLIVPGKS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 AAGISLIVPGKSPTR 15 1 P47736-4;F2Z357;J3KPC5;P47736;P47736-3 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 AAGISLIVPGKS(0.756)PT(0.244)R;AAGISLIVPGKS(0.832)PT(0.168)R 118.05 0.0011384 193964000.0 428250.0 318680.0 376110.0 338740.0 330610.0 258308.0 261530.0 292470.0 207880.0 303480.0 True False 404449.5794205793 343121.7312822947 351911.4920776048 292603.0276409073 289075.81610909995 293887.58231343975 273691.66321186366 293321.03927898523 249461.80865250187 294717.7438642647 1.3723285680649508 1.1642384567124096 1.1940627919562294 0.9928246050080672 0.9808565046637872 0.9971831979305349 0.9286568892096133 0.9952608737873525 0.8464431268427262 1.0 18.168974396840888 -4.494887859235143 0.5583571645541598 0.9362210730136233 1.7758809238646502 0.8560742292280944 0.05499196620272972 1.7801584657751746 0.3351647758843163 0.0280191893797462 1.0391125275963407 3.1997212147359716e-05 4.494887859235143 0.8396598508510269 AAGMS(ph)SPGAQSHPEELPR ddPTM_A459_Selumetinib_30min_R2 1 AAGMSSPGAQSHPEELPR 18 0 M0R300;M0R0P8;Q13459-2;Q13459;M0QZY4;M0R2J3 M0R300 MYO9B Unconventional myosin-IXb 1 AAGMS(0.5)S(0.5)PGAQSHPEELPR 250.38 1.4220999999999992e-79 0.0 13335.0 11992.0 16043.0 15870.0 18917.0 14292.0 13938.0 14647.0 10018.0 17065.0 True False 12593.894084234515 12911.747839642521 15010.810846297689 13708.478622723 16540.477339874276 16260.593270141364 14586.144617623046 14689.620345058624 12021.879926307322 16572.289109805213 0.7599369043582018 0.779116738435556 0.9057777562796889 0.8271928236282216 0.998080423910049 0.9811917449907732 0.880152676614419 0.8863965773061077 0.7254206010197117 1.0 14.016485273555361 -5.223592274200953 4.319148178669928 0.8998931104095438 0.7643905993171322 0.3047697653773652 0.07920805781920294 0.2637575620452705 11.372339213310243 0.02108069693137719 0.05825480894552681 5.975960604424213e-06 5.223592274200953 -0.13550251109241163 AAGMSS(ph)PGAQSHPEELPR ddPTM_A459_Selumetinib_30min_R1 2 AAGMSSPGAQSHPEELPR 18 0 M0R300;M0R0P8;Q13459-2;Q13459;M0QZY4;M0R2J3 M0R300 MYO9B Unconventional myosin-IXb 1 AAGMS(0.085)S(0.912)PGAQS(0.003)HPEELPR;AAGMS(0.191)S(0.792)PGAQS(0.017)HPEELPR 168.16 1.1855e-07 12243200.0 2080.3 3105.7 3198.1 3319.3999999999996 2969.1 2709.0 2822.7 2691.9 1589.1599999999999 2064.4 True False 2128.766942440845 2742.083200199241 2763.815585905839 2739.729102855106 2700.5454292371787 2681.749919575199 2609.7814664311936 2620.5020674764846 2696.6884523458593 2329.385848958854 0.9138747637675924 1.1771700259211446 1.186499689238328 1.1761594173329677 1.1593379561587958 1.1512690869886748 1.1203731951911986 1.1249755246206843 1.1576821648294875 1.0 11.185733917887557 -10.293979522245456 14.976002609191683 0.9999999623272201 1.1352297069375872 0.20764186650043026 0.07531885551107714 0.0 0.0 0.07107820933645595 0.017238997927880664 5.0818340374381587e-11 10.293979522245456 0.13522974461036708 AAGMSS(ph)PGAQSHPEELPR ddPTM_A459_Selumetinib_30min_R2 1 AAGMSSPGAQSHPEELPR 18 0 M0R300;M0R0P8;Q13459-2;Q13459;M0QZY4;M0R2J3 M0R300 MYO9B Unconventional myosin-IXb 1 AAGMS(0.241)S(0.759)PGAQSHPEELPR 98.188 0.0022046999999999995 14037000.0 24986.0 29088.0 35811.0 33941.0 36308.0 30035.0 29870.0 32992.0 23064.0 34045.0 True False 23597.3781468829 31318.95606733838 33506.95924806872 29318.177248509226 31746.664442361674 34172.04861941619 31259.014186282137 33088.0012578804 27677.4444620036 33062.03239046693 0.7137304164545838 0.9472786094169109 1.0134573353612129 0.8867627041876227 0.9602151515499535 1.0335737445248323 0.9454655968244507 1.0007854588945646 0.8371368140690615 1.0 15.012887792308057 -4.763039036753181 5.620410775446457 0.9605732362031504 0.7027471959065458 0.6261548198424737 0.05675824307786591 0.0901136501625495 9.473571888048223 0.01354995221931099 0.09021697484839047 1.7256827712532915e-05 4.763039036753181 -0.2578260402966046 AAGS(ph)PSPLPAPDPAPK ddPTM_A459_Selumetinib_30min_R1 4 AAGSPSPLPAPDPAPK 16 0 J3KRY8;Q9BZE9-3;Q9BZE9;Q9BZE9-2;J3KRF7 J3KRY8 ASPSCR1 Tether containing UBX domain for GLUT4 1 AAGS(0.765)PS(0.235)PLPAPDPAPK;AAGS(0.986)PS(0.014)PLPAPDPAPK;AAGS(0.941)PS(0.059)PLPAPDPAPK;AAGS(0.77)PS(0.23)PLPAPDPAPK 213.51 2.032e-08 81939500.0 19144.8 21542.0 23511.2 25207.1 22602.4 20336.199999999997 20411.0 20329.9 11459.46 17197.9 True False 19590.83659070398 19019.852625395888 20318.50817777723 20805.153180869715 20558.01691077784 20131.63629179224 18871.381837009616 19790.685011178033 19445.866654156456 19405.41798673197 1.0095549915028261 0.9801310457935148 1.047053363739424 1.072131154046503 1.0593957277722095 1.0374234817078822 0.9724800491240391 1.019853580309864 1.0020844007303602 1.0 14.244171888214723 -10.410762198976066 8.989712066604632 1.000001629721565 1.0231997584315677 0.04372802627392813 0.030897210699293434 0.0 0.0 0.03319613204018901 0.008051244633155883 3.883629586746274e-11 10.410762198976066 0.023198128710002708 AAGS(ph)PSPLPAPDPAPK ddPTM_A459_Selumetinib_30min_R2 1 AAGSPSPLPAPDPAPK 16 0 J3KRY8;Q9BZE9-3;Q9BZE9;Q9BZE9-2;J3KRF7 J3KRY8 ASPSCR1 Tether containing UBX domain for GLUT4 1 AAGS(0.917)PS(0.083)PLPAPDPAPK 183.23 8.798200000000002e-07 40137000.0 129860.0 114820.0 110610.0 111100.0 112350.0 87276.0 94454.0 92611.0 75609.0 103030.0 True False 122642.90107076809 123626.32479550983 103493.47302306205 95967.98834180985 98235.58857825649 99297.47678735362 98846.29815705022 92880.48267742369 90732.91269197155 100055.25619591176 1.2257517069431008 1.2355805131660957 1.0343631804851725 0.9591498936737627 0.9818133730616581 0.9924263908027542 0.9879170961643998 0.9282918879899762 0.906828048236799 1.0 16.610437432670885 -5.359985944242795 2.908689802626219 0.965580246872887 1.2376450739554175 0.9306028076741206 0.028532677074385622 0.06431161070796641 1.0359017394562988 0.008481295246098211 0.02196561367039062 4.365299601190551e-06 5.359985944242795 0.27206482708253044 AAGS(ph)PSSSDQDEK ddPTM_A459_Selumetinib_30min_R2 1 AAGSPSSSDQDEK 13 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 AAGS(0.955)PS(0.029)S(0.007)S(0.009)DQDEK 113.37 0.0052379 0.0 2778.2 1233.7 2007.1 2321.4 3328.1 3366.1 4368.9 10777.0 3526.1 4845.5 True False 2623.7987660157705 1328.320823029268 1877.96537116525 2005.2213153616376 2909.9943244085016 3829.7497205865416 4572.062506811115 10808.35928577161 4231.418527465787 4705.597824879059 0.5575909509613066 0.28228524248423376 0.399091771344381 0.426135294597382 0.6184111844456858 0.8138710240680146 0.9716220291156361 2.2969152248044917 0.8992308065712226 1.0 12.200162307126844 -7.169564650658063 1.8173136194100457 1.445202048608293 0.43809474127904763 0.526240302301159 0.3753288535430028 0.24906976579121132 1.6156573885212233 0.1813103454527932 0.12160442373886009 6.767610403078413e-08 7.169564650658063 -1.0071073073292454 AAGSPS(ph)PLPAPDPAPK ddPTM_A459_Selumetinib_30min_R1 1 AAGSPSPLPAPDPAPK 16 0 J3KRY8;Q9BZE9-3;Q9BZE9;Q9BZE9-2;J3KRF7 J3KRY8 ASPSCR1 Tether containing UBX domain for GLUT4 1 AAGSPS(1)PLPAPDPAPK 113.43 0.0022733 24574000.0 8666.0 10173.0 10716.0 12101.0 10540.0 9464.3 9728.1 9186.0 6030.7 8428.5 True False 8867.90093889937 8981.940430700612 9260.82605877457 9987.787513903007 9586.658860988142 9369.097734896846 8994.301584861763 8942.357439666774 10233.657435099147 9510.380075542387 0.9324444310805975 0.9444354862114553 0.9737598271798212 1.0501985656270834 1.0080205822311896 0.9851444064776261 0.9457352401711252 0.9402734032327075 1.0760513621760286 1.0 13.215287283176227 -5.3576796394614945 3.60028771175628 0.9964445453737131 0.9375677002513049 0.27852929906257096 0.039264251615100026 0.3352753195258934 7.993635299246658 0.010999293832606427 0.025984295065866317 4.388543025295256e-06 5.3576796394614945 -0.058876845122408206 AAGSPS(ph)PLPAPDPAPK ddPTM_A459_Selumetinib_30min_R2 4 AAGSPSPLPAPDPAPK 16 0 J3KRY8;Q9BZE9-3;Q9BZE9;Q9BZE9-2;J3KRF7 J3KRY8 ASPSCR1 Tether containing UBX domain for GLUT4 1 AAGS(0.006)PS(0.994)PLPAPDPAPK;AAGS(0.029)PS(0.971)PLPAPDPAPK;AAGS(0.019)PS(0.981)PLPAPDPAPK;AAGS(0.287)PS(0.713)PLPAPDPAPK 220.52 8.0625e-11 55785000.0 476106.0 437035.0 457282.0 511943.0 458064.0 344204.0 380587.0 411024.0 322206.0 426849.0 True False 449645.93452332675 470554.1792109883 427860.9739709964 442215.4802490664 400517.9051758824 391614.9766271858 398285.0496188332 412220.0117913142 386656.20318783994 414524.76028310787 1.0847263604138682 1.1351654335186492 1.0321722969667246 1.0668011241283792 0.966209846915636 0.9447324120270274 0.9608233036473298 0.994440022134698 0.9327698613799703 1.0 18.661098753409405 -5.978300580118391 1.3866835912825055 0.9631338568377997 1.1028057804624607 0.7705194307227211 0.030236180101720637 0.18691092700284886 0.7291649981317506 0.010369866168303295 0.019176319151909624 1.0512340510195783e-06 5.978300580118391 0.13967192362466097 AAGTDGSDFQHR ddPTM_A459_Selumetinib_30min_R2 1 AAGTDGSDFQHR 12 0 A0A3B3ITE9;Q8N5M9 A0A3B3ITE9 JAGN1 Protein jagunal homolog 1 0 104.59 0.019001 0.0 6150.2 3461.8 6691.5 6903.2 5822.5 3650.2 7015.7 6111.9 6263.6 5439.7 False True 5808.396505201284 3727.3089285585816 6260.976175154335 5962.972251315777 5091.025496189565 4152.98191678352 7341.943951345815 6129.684617120487 7516.495019606563 5282.641726962052 1.0995249735668868 0.7055767021895097 1.1851979556362804 1.1287860429529772 0.9637271954684153 0.7861562701833694 1.3898243210159982 1.1603445650753137 1.4228667034607243 1.0 12.36704385312471 -7.269406926263821 24.98951901384596 1.256620941652159 0.9813725126368259 0.3496848404145375 0.17669859297807636 678.646273650349 2128505.592737072 0.07156023317001456 0.04922817205826982 5.377656694404669e-08 7.269406926263821 -0.2752484290153331 AAHTEDINACT(ph)LTTSPR ddPTM_A459_Selumetinib_30min_R2 1 AAHTEDINACTLTTSPR 17 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 AAHTEDINACT(0.454)LT(0.182)T(0.182)S(0.182)PR 95.307 0.0087402 21272000.0 32439.0 26415.0 33879.0 35421.0 46596.0 29719.0 35261.0 40447.0 43454.0 54338.0 True False 30636.170243605815 28440.945562388046 31699.262024666175 30596.59869536682 40742.193906474706 33812.52248777857 36900.706368345986 40564.6940736387 52146.014206204716 52769.12075292091 0.5805700342640259 0.5389694798129409 0.6007161304257952 0.5798201345561214 0.7720840014985376 0.6407634238610458 0.6992859809267038 0.7687202950296141 0.9881918338258137 1.0 15.687406324877552 -7.89966211187496 0.5899428539263369 1.0279736119322052 0.5760199228119152 0.8504928556051347 0.0609059094190821 0.28502722470878283 0.21727648488547252 0.061510687208930534 0.03340112583218926 1.2599052572269113e-08 7.89966211187496 -0.45195368912029 AAHTEDINACTLTTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AAHTEDINACTLTTSPR 17 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 AAHTEDINACT(0.076)LT(0.161)T(0.161)S(0.602)PR;AAHTEDINACT(0.035)LT(0.267)T(0.048)S(0.65)PR 153.48 0.00012519 28360700.0 5957.799999999999 7910.5 5594.3 5791.700000000001 6408.0 6522.5 8554.5 8144.099999999999 4245.3 6569.200000000001 True False 6096.60514813924 6984.334982508319 4834.624787290272 4780.288318673835 5828.39753142429 6456.889571956165 7909.227177732537 7928.092012234942 7203.964035555814 7412.420809426708 0.8224850295042496 0.9422475007929969 0.6522329090034747 0.6449024470648682 0.7863014906023759 0.8710905300660547 1.067023497596631 1.0695685277544458 0.9718773691847352 1.0 12.855729071375345 -7.038581396760754 2.9109441591981735 1.0324461613061193 0.7664342094235442 0.6758168140488462 0.08384820611474708 0.1731356722874946 2.933766273731532 0.03780846783553875 0.029749557843555367 9.14994752177499e-08 7.038581396760754 -0.2660119518825751 AAHTEDINACTLTTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AAHTEDINACTLTTSPR 17 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 AAHTEDINACTLTT(0.004)S(0.996)PR 214.34 9.9316e-10 6288200.0 15807.0 16175.0 19468.0 19745.0 22015.0 18788.0 22476.0 21485.0 20064.0 22933.0 True False 14928.51022043457 17415.57048917761 18215.45007515574 17055.696937975157 19249.278883402887 21375.876459516927 23521.1785353491 21547.517792966784 24077.36063500003 22270.864702910225 0.6703156980915878 0.7819889672672587 0.8179049317638507 0.7658300279533564 0.8643256173563618 0.9598134937582219 1.0561412342591032 0.9675204838432286 1.0811147638939114 1.0 14.44286995376774 -6.63447482398936 1.3577060160950618 1.0288258105845833 0.7546717217256407 0.8796746039098716 0.04494624588000037 0.13596441068887663 0.5230413771659713 0.019805383892337557 0.02002036502189699 2.3201986833726153e-07 6.63447482398936 -0.27415408885894266 AAHVPENS(ph)DTEQDVLTVKPVR ddPTM_A459_Selumetinib_30min_R1 2 AAHVPENSDTEQDVLTVKPVR 21 1 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BS99 H3BSS6 ZNF106 Zinc finger protein 106 1 AAHVPENS(0.983)DT(0.017)EQDVLTVKPVR;AAHVPENS(1)DTEQDVLTVKPVR 202.79 3.5779e-17 23673700.0 4556.7 5449.8 4699.8 5578.9 5623.0 4631.9 5500.7 5013.5 2455.89 4785.0 True False 4662.862244205256 4811.734882456718 4061.5929741534815 4604.649843923106 5114.4006428212815 4585.30729142871 5085.777770361025 4880.525693856888 4167.465958891281 5399.201359846986 0.8636207345186699 0.8911938195602105 0.7522581032741086 0.8528390658231726 0.9472513251415806 0.8492565818213268 0.9419500091593467 0.9039347430441459 0.7718671116591561 1.0 12.398530306864258 -6.016012612551488 24.379626076625847 0.89718232577393 0.8347924229741643 0.17619849735470916 0.06629706047898871 943.2802252012845 1436172.0014097157 0.018928226807984554 0.025211423259308266 9.638010330158118e-07 6.016012612551488 -0.06238990279976564 AAHVPENS(ph)DTEQDVLTVKPVR ddPTM_A459_Selumetinib_30min_R2 6 AAHVPENSDTEQDVLTVKPVR 21 1 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BS99 H3BSS6 ZNF106 Zinc finger protein 106 1 AAHVPENS(0.971)DT(0.029)EQDVLTVKPVR;AAHVPENS(0.988)DT(0.011)EQDVLTVKPVR;AAHVPENS(0.986)DT(0.014)EQDVLTVKPVR;AAHVPENS(0.989)DT(0.011)EQDVLTVKPVR;AAHVPENS(0.996)DT(0.004)EQDVLTVKPVR;AAHVPENS(0.973)DT(0.027)EQDVLT(0.001)VKPVR 102.84 0.00011113 147959500.0 308162.0 269448.0 355819.0 373338.0 392157.0 280513.1 317067.0 321571.0 289190.0 327924.0 True False 291035.58971022675 290113.7951881254 332925.99292643426 322488.72035602754 342890.73173193826 319151.2332806107 331811.24375634117 322506.7183710549 347036.0806437226 318455.9820711264 0.9138958163619129 0.9110012419968583 1.045438024938957 1.0126634087972648 1.0767288135141841 1.0021831940633132 1.0419375437646259 1.0127199252894667 1.08974583672984 1.0 18.280734447118135 -5.2589999156939005 24.998554098626364 1.0353743990776823 0.9124485151667412 0.7461943557530182 0.0286304047264572 90.26808375247639 925013.5877848875 0.006828688541175743 0.016376797800455336 5.508078033292879e-06 5.2589999156939005 -0.12292588391094106 AAIPPPVYEEQDRPRS(ph)PTGPSNSFLANMGGTVAHK ddPTM_A459_Selumetinib_30min_R1 1 AAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHK 35 2 H0Y6J6;Q5W012;Q96I25 H0Y6J6 RBM17 Splicing factor 45 1 AAIPPPVY(0.012)EEQDRPRS(0.534)PT(0.322)GPS(0.066)NS(0.066)FLANMGGTVAHK 58.666 0.00020065 87840000.0 1205.4 1063.6 1607.4 1947.0 1396.2 1143.9 1145.9 948.61 523.02 597.97 True False 1233.4834746998959 939.0732175457741 1389.123908816186 1606.9929997164834 1269.9139565191301 1132.3934045780995 1059.463840430617 923.4497812804591 887.526740130591 674.7252742210449 1.8281269752699345 1.3917860400737367 2.0587992800772112 2.3816997244867113 1.8821200346840679 1.6783029298634504 1.5702151392709338 1.3686307843537668 1.3153897949876274 1.0 9.398156393868065 -7.760562792300759 0.9534487718340514 1.08096513113897 1.9051475482745805 0.6170536528468942 0.2377069018845229 0.4267557143769161 0.7057706410061855 0.23621021542945986 0.0979548272393222 1.7355503108552927e-08 7.760562792300759 0.8241824171356105 AAIPPPVYEEQDRPRS(ph)PTGPSNSFLANMGGTVAHK ddPTM_A459_Selumetinib_30min_R2 3 AAIPPPVYEEQDRPRSPTGPSNSFLANMGGTVAHK 35 2 H0Y6J6;Q5W012;Q96I25 H0Y6J6 RBM17 Splicing factor 45 1 AAIPPPVY(0.071)EEQDRPRS(0.835)PT(0.065)GPS(0.016)NS(0.01)FLANMGGT(0.003)VAHK;AAIPPPVY(0.016)EEQDRPRS(0.8)PT(0.081)GPS(0.081)NS(0.022)FLANMGGT(0.001)VAHK;AAIPPPVY(0.019)EEQDRPRS(0.804)PT(0.126)GPS(0.025)NS(0.025)FLANMGGTVAHK 80.342 1.0651e-06 18445500.0 95598.0 107307.0 118319.0 125704.0 114008.0 75042.0 54017.7 62267.0 48197.2 115135.0 True False 90285.04586911507 115537.10185361236 110706.48435598685 108582.89834850478 99685.29579554833 85378.35433654832 56529.63008404192 62448.18666114324 57837.9867422858 111810.75339334438 0.807480882912013 1.0333272815644028 0.990123767134698 0.9711310858135069 0.8915537438949246 0.7635969863845898 0.5055831247748921 0.558516822093612 0.5172846527454724 1.0 16.770699420410438 -6.878829976303139 2.55136602721584 0.6095368150852116 0.9546541644087313 0.4731042366474736 0.14415758468141462 0.20888532478326619 2.7635989264805882 0.053857378933705236 0.046459311845895454 1.3218130148081266e-07 6.878829976303139 0.3451173493235197 AAISQLRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AAISQLRSPR 10 1 C9JIG9;O95747 C9JIG9 OXSR1 Serine/threonine-protein kinase OSR1 1 AAIS(0.005)QLRS(0.995)PR 79.148 0.02792 5442700.0 24243.0 26213.0 31001.0 34568.0 32848.0 20669.0 23869.0 21587.0 21244.0 28359.0 True False 22895.67111241824 28223.45281192041 29006.429411336692 29859.778766873882 28721.340575154132 23515.967135499024 24978.955795526228 21649.81459607976 25493.393606954774 27540.201984469135 0.8313545095032308 1.0248092162808604 1.05323953062125 1.0842251187450562 1.0428877969504755 0.8538778019406134 0.9069997311425936 0.7861167687981676 0.925679253236101 1.0 14.749251520028984 -6.761365865492611 24.999999906611727 0.8819460624566586 1.0151012528513286 0.31320140320803647 0.08204263936281014 2.149366409349112 730967.0894025646 0.028100658258355702 0.026403235281920193 1.7323439931719858e-07 6.761365865492611 0.13315519039466994 AAKLS(ph)EGS(ph)QPAEEEEDQETPSR ddPTM_A459_Selumetinib_30min_R2 1 AAKLSEGSQPAEEEEDQETPSR 22 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 2 AAKLS(1)EGS(1)QPAEEEEDQETPSR 78.418 0.0028376 9173200.0 36827.0 40619.0 39174.0 40500.0 33900.0 26697.0 27520.0 31668.0 18465.0 31667.0 True False 34780.30277016156 43734.34668932954 36653.58748942628 34983.830133603115 29641.178930154812 30374.269418763255 28799.73452984546 31760.14863708039 22158.515955207098 30752.69142925294 1.1309677674935932 1.4221307032570176 1.191882264150715 1.1375859642751587 0.9638564155708069 0.9876946701930057 0.9364947648923578 1.0327599686728273 0.7205390788699948 1.0 14.908425058024672 -6.053145882222643 1.505059104036242 0.9339177379509964 1.2803831698409325 0.6484069834024342 0.10411507625838932 0.23316659326764608 1.0639904368918103 0.034919431258870176 0.05779897196703096 8.848183439117013e-07 6.053145882222643 0.34646543188993606 AAKLS(ph)EGSQPAEEEEDQETPSR ddPTM_A459_Selumetinib_30min_R1 4 AAKLSEGSQPAEEEEDQETPSR 22 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AAKLS(0.93)EGS(0.069)QPAEEEEDQET(0.001)PSR;AAKLS(0.9)EGS(0.1)QPAEEEEDQETPSR;AAKLS(0.975)EGS(0.025)QPAEEEEDQETPSR;AAKLS(0.581)EGS(0.418)QPAEEEEDQETPSR 130.48 1.3343e-05 84344000.0 7437.34 7788.31 12666.699999999999 12617.1 8760.61 9078.58 8219.759999999998 8346.06 4913.3099999999995 6090.639999999999 True False 7610.615551455552 6876.45104451291 10946.631713202676 10413.760337299864 7968.214372311317 8987.257727891109 7599.736885433257 8124.695376976402 8337.528216035787 6872.43297185756 1.1074121177493954 1.00058466523745 1.5928320811609014 1.5152945659774275 1.1594459203808831 1.3077257740735635 1.1058291752795535 1.1822152955506187 1.2131843628272194 1.0 12.746605215590527 -7.257998405172616 24.356836889532605 1.140491815096484 1.2871837584285533 0.15681857084474582 0.17453245003415466 478.33614466453486 3385909.867766224 0.07443131020004828 0.055226362340802866 5.520794666374739e-08 7.257998405172616 0.14669194333206925 AAKLS(ph)EGSQPAEEEEDQETPSR ddPTM_A459_Selumetinib_30min_R2 3 AAKLSEGSQPAEEEEDQETPSR 22 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AAKLS(0.999)EGS(0.001)QPAEEEEDQETPSR;AAKLS(0.63)EGS(0.37)QPAEEEEDQETPSR;AAKLS(0.523)EGS(0.477)QPAEEEEDQETPSR 90.765 0.00021546 40423000.0 82932.0 93073.0 108896.0 104304.0 102142.0 54729.0 51016.0 59304.0 47806.5 97499.0 True False 78322.97144309976 100211.3998231363 101889.74991700005 90097.61526556415 89310.00879893429 62267.42296960311 53388.34508628622 59476.56482169429 57369.13582521571 94683.95053717555 0.827204304412161 1.0583778903879861 1.0761037043653485 0.9515616401133297 0.9432433722108869 0.6576343996668705 0.5638584446824964 0.628158885262631 0.6059013750455099 1.0 16.530832281032737 -6.726227246139244 4.58073905191006 0.6582519914399726 0.985346519189808 0.5302351531714998 0.1301742188090314 0.1375251594498557 6.540934860984678 0.042990778975279205 0.04144914093170914 1.87833371479296e-07 6.726227246139244 0.3270945277498354 AAKLSEGS(ph)QPAEEEEDQETPSR ddPTM_A459_Selumetinib_30min_R2 1 AAKLSEGSQPAEEEEDQETPSR 22 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AAKLS(0.027)EGS(0.972)QPAEEEEDQET(0.001)PSR 82.831 0.00047496 12439000.0 50418.0 61397.0 74425.0 69494.0 68837.0 36846.0 44341.0 41400.0 37339.0 69116.0 True False 47615.96939924529 66105.95247752938 69636.57652781313 60028.79731616329 60189.08064941198 41921.20204531409 46402.944360024674 41520.46714586104 44807.84333882904 67120.44149506577 0.709410849193322 0.9848855431379878 1.0374868665447072 0.8943444944499687 0.896732490262846 0.6245668400199043 0.6913384853619579 0.6185964546868086 0.6675737277759565 1.0 16.034464584907745 -6.704432726782186 7.390778067615512 0.6949949907908186 0.9170790700832465 0.32539825848876724 0.1294790294235271 0.22481067612788996 24.350829675153076 0.04149601736481712 0.04126932472990542 1.9750007878970807e-07 6.704432726782186 0.2220840792924279 AAKNS(ph)EEEEEEK ddPTM_A459_Selumetinib_30min_R1 4 AAKNSEEEEEEK 12 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK 186.42 0.0005235 117648000.0 11867.460000000001 24198.4 12173.740000000002 9175.56 6980.900000000001 13280.41 8984.1 15903.8 22825.0 16400.100000000002 True False 12143.948727942621 21365.240078469033 10520.612973567218 7573.220692593003 6349.478827578001 13146.821133047504 8306.422103859597 15481.97956117705 38732.35792795831 18505.212585501882 0.6562447565426476 1.1545525337659654 0.5685215949267025 0.4092479704084204 0.34311839424922747 0.7104388059474405 0.4488693153607626 0.8366280305964483 2.0930512280795743 1.0 14.175644088777839 -8.076959192722358 6.678786141257964 1.5369768746672279 0.6190035424396392 0.5640138563182432 0.3235534620877246 0.17674398630859814 12.722094143566963 0.21672657160743772 0.08109240717159175 8.376079819425861e-09 8.076959192722358 -0.9179733322275887 AAKNS(ph)EEEEEEK ddPTM_A459_Selumetinib_30min_R2 5 AAKNSEEEEEEK 12 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK;AAKNS(1)EEEEEEK 177.39 0.00049203 110934600.0 100969.9 65955.2 64867.3 49964.57 48555.2 75353.40000000001 192335.4 368667.0 87845.6 185281.2 True False 95358.39717253477 71013.7517606064 60693.808540176164 43159.309372309224 42455.26168700451 85732.64685994071 201279.37720536505 369739.75993389264 105417.1746111423 179931.6503376291 0.5299701136159282 0.39467070761233 0.33731591093778385 0.23986502258676454 0.23595216076404674 0.47647340920326925 1.1186435339623597 2.0548900609764984 0.5858734381268352 1.0 17.45708945629527 -7.270862189567947 3.8376398437797374 1.2962892251878257 0.34768172808563985 0.5641359929755017 0.3521193489477725 0.14717181045550987 4.955103250855587 0.14328407575645136 0.09939985949319889 5.359667036188888e-08 7.270862189567947 -0.9486074971021858 AAKPGPAEAPS(ph)PTASPSGDAS(ph)PPATAPYDPR ddPTM_A459_Selumetinib_30min_R2 2 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 2 AAKPGPAEAPS(0.647)PT(0.303)AS(0.072)PS(0.489)GDAS(0.413)PPAT(0.057)APY(0.019)DPR;AAKPGPAEAPS(0.921)PT(0.13)AS(0.029)PS(0.309)GDAS(0.58)PPAT(0.029)APY(0.002)DPR 64.221 0.0008511000000000001 27188000.0 59429.0 63844.0 72615.0 70921.0 70524.0 48230.0 49425.0 53563.0 50495.0 66449.0 True False 56126.174093136295 68740.62950918426 67943.02995723407 61261.43745445103 61664.14462744064 54873.2447116512 51723.360433779526 53718.85946216799 60595.41094818212 64530.444714763864 0.8697627041193354 1.0652433872574436 1.0528833368118637 0.9493416282072371 0.955582204647856 0.8503466070038844 0.8015342318250874 0.8324576050826084 0.9390205075453099 1.0 15.977692347470347 -6.510678204742001 2.358735500868821 0.8696384986808924 0.9962218889613559 0.2719726288838684 0.07407329106801755 0.32688366033757765 3.6456810040019954 0.02625766671760354 0.028419763816605874 3.085473318745228e-07 6.510678204742001 0.1265833902804635 AAKPGPAEAPS(ph)PTASPSGDASPPATAPYDPR ddPTM_A459_Selumetinib_30min_R1 1 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 AAKPGPAEAPS(0.451)PT(0.451)AS(0.098)PSGDASPPATAPYDPR 115.5 4.9238e-16 106860000.0 1444.8 1619.7 1836.4 1924.6 1808.8 1623.1 1711.1 1670.9 953.63 1256.5 True False 1478.461028908586 1430.0647710218982 1587.0269666231443 1588.5047392164056 1645.194359369577 1606.7730876568862 1582.0303493854858 1626.5823041518847 1618.240459620542 1417.7840143464434 1.0427970790671617 1.0086619376091046 1.1193714631877245 1.1204137746951952 1.1603984406101255 1.1332989167588838 1.1158472188831634 1.147270873202567 1.1413871529412771 1.0 10.469422053371524 -5.270465530279684 22.147520568154416 1.1246854769167307 1.0257295053274091 0.41334180745794435 0.04288627643585381 97.86807915134217 240143.1565566043 0.010336693654200823 0.022131032913788973 5.364564480114579e-06 5.270465530279684 -0.09895597158932157 AAKPGPAEAPS(ph)PTASPSGDASPPATAPYDPR ddPTM_A459_Selumetinib_30min_R2 2 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 AAKPGPAEAPS(0.615)PT(0.31)AS(0.052)PS(0.008)GDAS(0.01)PPAT(0.002)APY(0.002)DPR;AAKPGPAEAPS(0.685)PT(0.294)AS(0.017)PS(0.001)GDAS(0.001)PPATAPYDPR 59.678 0.0010989 190840000.0 65453.9 64694.7 63218.8 80740.0 70565.7 52006.9 53002.3 59827.4 48190.7 64888.2 True False 61816.23427072194 69656.57546375255 59151.37123542509 69743.07271573113 61700.605900637835 59170.37840336657 55467.011972065004 60001.48782904079 57830.18656066067 63014.70906620936 0.9809810310442252 1.1054018418233844 0.9386914914305948 1.106774493594064 0.9791460885078307 0.9389931220851379 0.8802232493652551 0.9521822558285147 0.9177252012684638 1.0 15.943401005304654 -6.555509348640572 4.199243586711368 0.9322247892053771 1.0328671925555135 0.3940263172858176 0.05515115292679138 0.19495732502658253 7.753217969546896 0.017269419674363278 0.017792676107833746 2.7828554693485346e-07 6.555509348640572 0.10064240335013641 AAKPGPAEAPSPT(ph)ASPSGDAS(ph)PPATAPYDPR ddPTM_A459_Selumetinib_30min_R1 1 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 2 AAKPGPAEAPS(0.162)PT(0.737)AS(0.121)PS(0.327)GDAS(0.606)PPAT(0.047)APY(0.001)DPR 83.319 1.5686e-05 18899000.0 2623.6 3049.5 3175.9 3717.6 3061.2 2444.9 3055.1 2490.7 1832.2 2322.2 True False 2684.724775363072 2692.4631223259103 2744.6302239699658 3068.3909479948643 2784.315000498755 2420.3065257915873 2824.651347324878 2424.638545066189 3109.10958140658 2620.276990143503 1.0245957910030112 1.0275490463237071 1.0474580490132275 1.171017781531112 1.0626033091052212 0.9236834635788013 1.0779972338612118 0.9253367312642014 1.186557601773355 1.0 11.355503612143936 -6.5538792264704915 24.999290142836742 1.0183525487122607 1.0700307579429533 0.06840622285432851 0.08023612685566187 519.7842144665038 419158.90194776125 0.02565701078842733 0.025657258966128128 2.7933205314549314e-07 6.5538792264704915 0.05167820923069266 AAKPGPAEAPSPT(ph)ASPSGDASPPATAPYDPR ddPTM_A459_Selumetinib_30min_R1 3 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 AAKPGPAEAPS(0.182)PT(0.788)AS(0.005)PS(0.023)GDAS(0.003)PPATAPYDPR;AAKPGPAEAPS(0.006)PT(0.971)AS(0.023)PSGDASPPATAPYDPR;AAKPGPAEAPS(0.417)PT(0.56)AS(0.021)PS(0.001)GDASPPATAPYDPR 106.54 6.347499999999999e-11 257373000.0 9384.3 11143.1 12108.3 12896.7 11923.7 9312.3 10037.6 9254.8 5859.7 8800.099999999999 True False 9602.93593133087 9838.460671713357 10464.059366131029 10644.533446041889 10845.203440300213 9218.626716891897 9280.455750681876 9009.332640172874 9943.482924445003 9929.678555232904 0.9670943402563781 0.9908136116378636 1.0538165266806656 1.0719917454359345 1.0922008582629124 0.9283912531119867 0.9346179434772448 0.9073136245105325 1.0013902131005867 1.0 13.277531300071571 -6.7771440965534335 24.999580207815292 0.9473169014107312 1.0357985131995417 0.4536276142611907 0.0440214485207967 222.15093724660233 353629.36396414327 0.016467750207608826 0.014571085811531515 1.6705362474821014e-07 6.7771440965534335 0.08848161178881053 AAKPGPAEAPSPT(ph)ASPSGDASPPATAPYDPR ddPTM_A459_Selumetinib_30min_R2 1 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 AAKPGPAEAPS(0.281)PT(0.681)AS(0.036)PS(0.002)GDAS(0.001)PPATAPYDPR 76.711 3.7332e-05 53046000.0 67934.0 54310.0 67237.0 69458.0 71277.0 57200.0 59072.0 62133.0 51394.0 70114.0 True False 64158.500241348826 58475.40236582599 62911.044622110465 59997.70057826677 62322.54603553519 65078.78079009842 61818.965048947364 62313.796743328116 61674.23606834083 68089.62664195045 0.9422654140655893 0.8588004553662646 0.9239446259990295 0.8811577260331429 0.9153016268286874 0.9557811372988637 0.9079057721086152 0.9151731301304594 0.9057802063250402 1.0 16.055147401984286 -6.5225408439679216 24.99052576269055 0.9304490238009693 0.8998568169574855 0.187388236336697 0.03353080438354229 22.282077411779802 1648141.7959418125 0.010352312089953311 0.010457014478432147 3.0023350478447526e-07 6.5225408439679216 -0.030592206843483738 AAKPGPAEAPSPTASPSGDAS(ph)PPATAPYDPR ddPTM_A459_Selumetinib_30min_R2 2 AAKPGPAEAPSPTASPSGDASPPATAPYDPR 31 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 AAKPGPAEAPSPTASPS(0.031)GDAS(0.773)PPAT(0.174)APY(0.022)DPR;AAKPGPAEAPSPTASPS(0.138)GDAS(0.837)PPAT(0.019)APY(0.006)DPR 119.8 2.6479e-16 157617000.0 71892.6 63484.0 73430.9 77906.0 72595.8 53443.2 51500.5 58532.9 48277.0 70970.8 True False 67897.09710088023 68353.0186667666 68706.43583951896 67295.06840465391 63475.66658931357 60804.51569093338 53895.37529630474 58703.22104835675 57933.74897208411 68921.68859971648 0.9851339756809083 0.9917490423623745 0.9968768501676205 0.9763990083802262 0.920982463995734 0.882226145735836 0.7819799019916417 0.8517379977338256 0.8405735574552134 1.0 16.07267042795784 -6.5159117977080045 1.9658148402197975 0.8548871099654828 0.9905060611267553 0.5185468409991112 0.05204030147316517 0.23304491379161277 1.8120205942870917 0.018499927998688912 0.020144139282258777 3.0485140594891396e-07 6.5159117977080045 0.13561895116127254 AALAACPS(ph)SPFPPAMPR ddPTM_A459_Selumetinib_30min_R1 1 AALAACPSSPFPPAMPR 17 0 Q8N2G8-3;Q8N2G8 Q8N2G8-3 GHDC GH3 domain-containing protein 1 AALAACPS(0.5)S(0.5)PFPPAMPR 89.74700000000001 0.0093614 15654000.0 2018.6 2643.9 2241.5 2629.4 2487.8 1839.1 2080.5 1877.6 1174.8 1674.1 True False 2065.6294524881437 2334.3509588842367 1937.1166116781646 2170.224649950962 2262.778929256764 1820.6003237691953 1923.5662099798403 1827.7999486956592 1993.5497960028663 1888.9870421149067 1.0935117110043637 1.2357686457556116 1.0254790363778103 1.148882761800834 1.1978795400964533 0.9637971479840615 1.0183056670554071 0.9676085160696801 1.0553538756787295 1.0 10.883397089966621 -6.766934286312725 24.999951592768454 1.000069350938756 1.1397053103616173 0.5904751244427884 0.05799696069560167 95.00369049238212 432231.7410779869 0.019537442439587587 0.017724458493968677 1.710274079404132e-07 6.766934286312725 0.13963595942286133 AALAPAKES(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AALAPAKESPR 11 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;H0YAB7;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AALAPAKES(1)PR;AALAPAKES(1)PR 156.0 0.0019574 1770470000.0 12713.3 13883.7 15087.4 16503.300000000003 14227.5 11815.9 13491.7 13123.599999999999 7390.7 10259.3 True False 13009.495154224487 12258.189949642978 13038.613949155973 13621.3084603087 12940.62513706914 11697.042773978807 12474.010206770017 12775.519496539382 12541.478104629197 11576.181089044545 1.123815795049751 1.0589148403391746 1.1263312010120026 1.1766668433685459 1.1178665086118837 1.0104405489171764 1.0775583165829323 1.1036039777081463 1.0833864819632262 1.0 13.49887177514118 -6.622977122054463 12.433480707941 1.0629033196506081 1.121054225695119 0.39627028730690816 0.03998713534704365 0.6377202077748908 74.99842689646908 0.013811432098409328 0.013809772391788041 2.3824449694811243e-07 6.622977122054463 0.0581509060445109 AALAPAKES(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 AALAPAKESPR 11 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;H0YAB7;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AALAPAKES(1)PR;AALAPAKES(1)PR;AALAPAKES(1)PR;AALAPAKES(1)PR;AALAPAKES(1)PR;AALAPAKES(1)PR 147.52 0.0020016 2980880000.0 2657040.0 2790890.0 2958400.0 3120330.0 3076700.0 2398440.0 2543280.0 2710020.0 1895730.0 2644620.0 True False 2509372.3537738635 3004942.288874245 2768059.764862369 2695335.6711305124 2690177.4399530133 2728803.3391294354 2661547.559413711 2717905.7095320355 2274928.97112184 2568262.9490520377 0.9770698731218659 1.1700290618541953 1.077794532636963 1.0494780809439228 1.0474696295976917 1.0625093276125228 1.0363220636719093 1.0582661368592465 0.885785068059924 1.0 21.292361488245746 -8.239173781419133 22.14063522794205 0.9428926282738245 1.0626806719111235 0.44960017477070136 0.051695086364393385 134.17483552047054 133423.04168286367 0.033509713334512616 0.012627739798759016 5.765357184766099e-09 8.239173781419133 0.119788043637299 AALEEVYPDLTPEETRR ddPTM_A459_Selumetinib_30min_R2 1 AALEEVYPDLTPEETRR 17 1 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 0 108.06 0.0052357 0.0 7197.2 7111.8 10629.0 9555.3 12689.0 10379.0 5320.3 8801.9 9856.8 8715.8 False True 6797.208436674363 7657.252191958781 9945.141711980183 8253.851656188093 11094.894378900717 11808.613038818736 5567.70449197445 8827.512071767012 11828.435422002995 8464.152207632013 0.8030583890664692 0.9046685366851436 1.1749719839646529 0.9751539733354164 1.310809884644631 1.3951324065475887 0.6577982478805291 1.042929268664068 1.3974743284197386 1.0 13.04714985578386 -5.103597351804133 3.6765093183106194 1.1157041577370141 0.8181860324191627 0.2061504217785305 0.21177393384948118 0.38369062108430957 9.1772265039783 0.056514915643047815 0.1893371989352586 7.877758231887776e-06 5.103597351804133 -0.2975181253178515 AALEQPCEGS(ph)LTRPK ddPTM_A459_Selumetinib_30min_R1 3 AALEQPCEGSLTRPK 15 1 D6RGY3;D6R960;Q6PUV4 D6RGY3 CPLX2 Complexin-2 1 AALEQPCEGS(0.963)LT(0.037)RPK;AALEQPCEGS(0.938)LT(0.062)RPK;AALEQPCEGS(0.951)LT(0.049)RPK 192.78 0.00014403 385318000.0 16413.4 18352.0 19332.1 23013.9 18348.3 18155.800000000003 19646.4 18001.6 10872.6 17106.6 True False 16795.80028508319 16203.339308386656 16706.907003624092 18994.95438940688 16688.699504655473 17973.16913614744 18164.45623059261 17524.139090562316 18450.008096714977 19302.39874239465 0.8701405721245353 0.8394469270183813 0.8655352749982326 0.9840722203964984 0.864591998506455 0.9311365585186173 0.9410465752475244 0.9078736443296724 0.9558401700713222 1.0 14.236492524385682 -1.5228787454086399 0.09835705869197985 1.0436991144313064 0.4909237745856693 0.5424033520769618 0.0353785234771912 105.98294947155281 0.743420479120307 0.48695626576762596 7.9013582081792375 0.02999999999113719 1.5228787454086399 -0.552775339845637 AALEQPCEGS(ph)LTRPK ddPTM_A459_Selumetinib_30min_R2 4 AALEQPCEGSLTRPK 15 1 D6RGY3;D6R960;Q6PUV4 D6RGY3 CPLX2 Complexin-2 1 AALEQPCEGS(0.985)LT(0.015)RPK;AALEQPCEGS(0.937)LT(0.063)RPK;AALEQPCEGS(0.771)LT(0.229)RPK;AALEQPCEGS(0.967)LT(0.033)RPK 136.66 0.00022261 472881000.0 360216.0 274464.0 312793.0 344457.0 316625.0 201339.0 234332.0 264565.0 172292.0 254500.0 True False 340196.6367788991 295514.50625914335 292668.23892326816 297541.36237853207 276847.7368365856 229071.61967653202 245228.9023200491 265334.8403489064 206755.21424070044 247151.9237295884 1.376467686940248 1.195679571494936 1.1841633053339276 1.2038804225698656 1.1201520613672735 0.9268453840851417 0.9922192739570043 1.0735697960385375 0.8365511023370127 1.0 17.915038610306915 -5.9493577326692435 0.5865852290940204 0.9472643160778024 1.3560496725863802 0.7563884744414935 0.07399508439987736 0.640896003410677 0.3966994693398986 0.050043216915402165 0.1518381408355919 1.1236790071197638e-06 5.9493577326692435 0.40878535650857784 AALEQPCEGSLT(ph)RPK ddPTM_A459_Selumetinib_30min_R2 1 AALEQPCEGSLTRPK 15 1 D6RGY3;D6R960;Q6PUV4 D6RGY3 CPLX2 Complexin-2 1 AALEQPCEGS(0.119)LT(0.881)RPK 103.88 0.0074267 452410000.0 58695.0 52196.0 49032.0 59171.0 60953.0 31363.0 46608.0 52057.0 21345.0 39279.0 True False 55432.96687470149 56199.265363407336 45877.33450200514 51111.80772433163 53295.53921326625 35682.96856503247 48775.364351999895 52208.477251499724 25614.596429130543 38144.913210901774 1.4532204220314966 1.4733095616887038 1.2027117285167515 1.3399377117923008 1.3971860132069838 0.9354581138445038 1.2786859438458482 1.3686877975797465 0.6715075293921476 1.0 15.219203059814838 -6.602387261679675 0.3143864175147567 0.9275078665015378 1.5534044848202384 0.4160700578361435 0.19023693965216681 2.624884063140649 0.50096320802072 0.24529989324769585 0.590828291377702 2.498116790069252e-07 6.602387261679675 0.6258966183187006 AALEQPCEGSLTRPK ddPTM_A459_Selumetinib_30min_R2 2 AALEQPCEGSLTRPK 15 1 D6RGY3;D6R960;Q6PUV4 D6RGY3 CPLX2 Complexin-2 0 ; 135.02 0.0011593 15853000.0 36380.0 35105.0 41745.0 46312.0 42104.0 29544.0 32421.0 30103.0 23719.0 36650.0 False True 34358.14524067879 37797.440619633984 39059.17214851943 40004.22570734391 36814.51910546424 33613.417826270415 33928.64074099274 30190.59474618006 28463.46276423274 35591.81927186409 0.9653382699613632 1.061969896254038 1.0974199394015336 1.1239724893458283 1.0343533952074968 0.9444141522948889 0.9532707637626683 0.8482453373785872 0.7997192429759713 1.0 15.11925805747767 -6.99920258579314 1.5790581757782833 0.8790140322170518 1.0658588630448664 0.5782689736694627 0.06381495624618601 0.26361506952460834 1.330615241818239 0.03196304719415222 0.023927029225402085 1.0018378007552494e-07 6.99920258579314 0.18684483082781467 AALHS(ph)PVSEGAPVIPPSSGLPLPTPDAR ddPTM_A459_Selumetinib_30min_R2 2 AALHSPVSEGAPVIPPSSGLPLPTPDAR 28 0 E9PCV4;M0R344;Q9NRA0-4;Q9NRA0-2;Q9NRA0;Q9NRA0-5;Q9NRA0-3 E9PCV4 SPHK2 Sphingosine kinase 2 1 AALHS(0.917)PVS(0.083)EGAPVIPPSSGLPLPTPDAR;AALHS(0.97)PVS(0.03)EGAPVIPPSSGLPLPTPDAR 97.913 6.6593e-07 6494600.0 16394.0 15387.400000000001 16164.5 21482.5 21942.3 14958.8 14238.8 16854.4 19205.4 19469.3 True False 15482.887110381747 16567.56410171075 15124.493668576892 18556.54644062048 19185.712107349136 17019.238917533632 14900.932413646939 16903.44351360387 23047.016643711595 18907.1707216836 0.81888968679091 0.8762582379768917 0.7999342625722122 0.9814554865863137 1.0147320500653274 0.9001473127872696 0.7881101108669778 0.894022895462526 1.2189563940034789 1.0 14.206645873393372 -3.3769061783204277 0.15518742315217884 1.0596467810363597 0.4872812122156039 0.25112807975551177 0.10693108648029044 62.89259922096618 1.077554464293532 0.4230006114312323 7.446771071444798 0.00041984967532785014 3.3769061783204277 -0.5723655688207558 AALLKAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AALLKASPK 9 1 P50914 P50914 RPL14 60S ribosomal protein L14 1 AALLKAS(1)PK 68.355 0.043749 646700000.0 575180.0 745130.0 622470.0 516270.0 395720.0 352890.0 421400.0 303690.0 191450.0 549850.0 True False 543213.7982279718 802279.0750294208 582420.9578940937 445953.135384574 346006.11581831437 401497.3942835286 440995.93498825876 304573.68762141396 229745.34955994575 533974.4018181302 1.0173030699194239 1.5024672948698283 1.0907282369922748 0.8351582657635789 0.647982589877338 0.7519038233227465 0.8258746739295201 0.5703900535013862 0.43025536201302067 1.0 19.026411056695657 -5.749809747941654 2.5390841580937877 0.6942046393065575 1.26723030493753 0.6091016071143094 0.1808597673611653 0.16995243076254066 2.233065265071563 0.051981726329559004 0.09559755305641535 1.7790585943193344e-06 5.749809747941654 0.5730256656309725 AALPSLTNPPSLS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 1 AALPSLTNPPSLSPIR 16 0 P42858 P42858 HTT Huntingtin 1 AALPSLTNPPS(0.029)LS(0.971)PIR 138.98 0.00040327 2853300.0 20254.0 17194.0 18873.0 19484.0 19948.0 12022.0 11544.0 12025.0 8341.8 18133.0 True False 19128.36376318604 18512.724512576173 17658.7317273687 16830.245588225273 17441.953902617333 13677.921375149699 12080.81887400204 12059.990759154089 10010.39308936619 17609.453174807957 1.0862554091430296 1.0512946840995854 1.002798414696445 0.9557506085596447 0.990488104853236 0.7767374284351601 0.6860416819350661 0.6848589016044566 0.5684670040570616 1.0 14.104062489499858 -6.79674875693405 2.485832223516304 0.7077197365312233 1.0228634052623775 0.6171944760775986 0.10764953835044586 0.17472647196439128 2.2114070112051554 0.03978581131964343 0.036028375326044505 1.5968026440492642e-07 6.79674875693405 0.3151436687311542 AALPSLTNPPSLS(ph)PIRR ddPTM_A459_Selumetinib_30min_R2 1 AALPSLTNPPSLSPIRR 17 1 P42858 P42858 HTT Huntingtin 1 AALPSLTNPPS(0.247)LS(0.753)PIRR 129.06 0.00049668 5693500.0 33863.0 30290.0 37231.0 37156.0 35612.0 33140.0 37544.0 32270.0 21661.0 33846.0 True False 31981.03002432946 32613.145602299188 34835.59799404783 32095.288702324902 31138.102184680607 37704.73418503253 39289.87039202465 32363.900357413906 25993.80525890825 32868.77803753104 0.9729911464250995 0.9922226364807368 1.0598385481282873 0.9764673534768182 0.9473459022153403 1.1471291735269131 1.1953553718109544 0.9846395968982893 0.7908357660642985 1.0 15.004430201895152 -8.008211442482615 24.82663753482736 0.8928577850518944 1.0420374623945257 0.3041633178645672 0.08790353560274589 413.8853396499296 1251342.0775659021 0.0540897192047792 0.024001226418606855 9.812700813229308e-09 8.008211442482615 0.14917967734263127 AALS(ph)LPAK ddPTM_A459_Selumetinib_30min_R2 1 AALSLPAK 8 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 AALS(1)LPAK 82.287 0.041681 1358000.0 17968.0 19024.0 21737.0 19924.0 26034.0 14404.0 19328.0 22655.0 15937.0 25035.0 True False 16969.41049160298 20483.079628198757 20338.465085456133 17210.31682918293 22763.37617308702 16388.02025350659 20226.790297705422 22720.922299262846 19124.845316985422 24312.174501258316 0.6979799561213539 0.8425029866060982 0.836554750970691 0.7078888327447709 0.9362953598374701 0.6740664128031165 0.8319613820087772 0.9345491617003197 0.7866365600491879 1.0 14.56939131454025 -14.522878745280298 0.148151561134923 1.6977688101750716 0.7469126903810724 0.3547209777665282 0.08409770731710028 151.59115862545875 1.336880914866288 30.91978138276532 0.42451858382339075 3.0000000000002712e-15 14.522878745280298 -0.9508561197939992 AAMYDIIS(ph)SPSKDSTK ddPTM_A459_Selumetinib_30min_R1 1 AAMYDIISSPSKDSTK 16 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 AAMYDIIS(0.924)S(0.075)PS(0.001)KDSTK 213.51 9.6457e-08 29749000.0 1778.8 2393.6 2810.9 2646.4 1708.6 2158.3 1759.1 1898.5 1089.0 1383.0 True False 1820.2425790577186 2113.3561992455484 2429.19521916848 2184.2559190804827 1554.057431677831 2136.5894615796064 1626.4096707404647 1848.145612802892 1847.953462586926 1560.52152156079 1.166432217632707 1.3542627705203505 1.556656018905056 1.3996961201123654 0.9958577374335127 1.3691509101666535 1.0422218779230774 1.1843128000916183 1.1841896680403705 1.0 10.607812538641364 -6.2388731891392295 24.43503666509467 1.146144225967003 1.381575766731633 0.42297221413377706 0.13615965029864652 607.4419217328447 657747.5933103362 0.039860662827705944 0.05141742969620057 5.769348996353697e-07 6.2388731891392295 0.23543154076463013 AAMYDIISS(ph)PSKDSTK ddPTM_A459_Selumetinib_30min_R1 1 AAMYDIISSPSKDSTK 16 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 AAMYDIIS(0.341)S(0.525)PS(0.134)KDSTK 224.33 1.1867000000000002e-10 27398000.0 2166.6 2093.0 2834.4 3043.1 1815.0 2276.0 2043.9 1543.1 1108.3 1643.3 True False 2217.077564530277 1847.9505869906973 2449.504048244741 2511.6797110617504 1650.8335704642757 2253.105506442656 1889.7269774466686 1502.1719753047898 1880.7041529706971 1854.233562097503 1.1956840874039223 0.9966115514058012 1.321033174199409 1.3545649061710145 0.8903050857287138 1.2151141865288806 1.0191418255362694 0.8101309382004378 1.014275758682337 1.0 10.8566072641471 -7.467956466038019 4.9837076963153955 0.9298889646408339 1.1569140667683686 0.34165983186639437 0.13942634355259495 0.23718948414660632 12.618202370059294 0.062414883529080915 0.04010371379700754 3.4044231415014746e-08 7.467956466038019 0.22702510212753468 AAMYDIISS(ph)PSKDSTK ddPTM_A459_Selumetinib_30min_R2 2 AAMYDIISSPSKDSTK 16 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 AAMYDIIS(0.367)S(0.627)PS(0.005)KDSTK;AAMY(0.002)DIIS(0.16)S(0.822)PS(0.015)KDS(0.001)TK 70.335 0.023564 79386000.0 427610.0 341860.0 376840.0 380960.0 371070.0 299900.0 306120.0 305980.0 217560.0 340420.0 True False 403845.14805845666 368079.562746847 352594.5246723685 329072.59080734383 324452.86919210997 341208.50277885486 320355.1865652728 306870.35114228405 261078.0791343001 330591.1900826187 1.2215847251027196 1.1133979784968242 1.0665575346525444 0.9954064133563411 0.9814322913778354 1.0321161392521767 0.9690372767804618 0.9282472139248281 0.789730903201182 1.0 18.334688753230772 -2.0574071953417215 0.3343867070941643 0.9125922855281642 3.213128858027373 0.7196378648356445 0.057311405421172634 22.20024341725118 0.4416681193930005 0.05286523891563827 29.82301561146495 0.008761789288506776 2.0574071953417215 2.3005365724992086 AAPEAS(ph)SPPAS(ph)PLQHLLPGK ddPTM_A459_Selumetinib_30min_R1 3 AAPEASSPPASPLQHLLPGK 20 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 2 AAPEAS(0.613)S(0.387)PPAS(1)PLQHLLPGK;AAPEAS(0.987)S(0.013)PPAS(1)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK 144.63 0.00012394 85633000.0 49108.3 61387.0 65555.0 68874.4 63013.5 56697.4 63747.3 59886.3 34500.3 45924.4 True False 50252.427841882265 54199.78150195794 56652.99106783939 56846.778972610635 57313.94005093702 56127.07563312031 58938.789837754346 58297.92078588244 58544.48929778486 51819.24408153748 0.9697638152113945 1.0459392540862753 1.0932809243356778 1.0970206142560153 1.106035818676815 1.0831318871576834 1.1373919261541963 1.1250245313140959 1.1297827734743722 1.0 15.661200349761176 -4.6514278023872295 1.2800854771015229 1.104457939552337 0.8769444036501834 0.5269120929472941 0.03681528166374782 1.2966353954611178 1.507651714822151 0.010277217942154809 0.4203628879699943 2.231373122677527e-05 4.6514278023872295 -0.22751353590215362 AAPEAS(ph)SPPAS(ph)PLQHLLPGK ddPTM_A459_Selumetinib_30min_R2 12 AAPEASSPPASPLQHLLPGK 20 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 2 AAPEAS(0.502)S(0.502)PPAS(0.996)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.559)S(0.449)PPAS(0.992)PLQHLLPGK;AAPEAS(0.5)S(0.5)PPAS(1)PLQHLLPGK;AAPEAS(0.505)S(0.505)PPAS(0.991)PLQHLLPGK;AAPEAS(0.8)S(0.2)PPAS(1)PLQHLLPGK;AAPEAS(0.529)S(0.529)PPAS(0.943)PLQHLLPGK 149.47 0.00029751 55514100.0 324060.0 311684.0 355759.8 357303.0 343433.0 257326.90000000002 278314.4 287437.6 269747.80000000005 366741.0 True False 306050.0425149636 335589.16057798057 332870.60178998363 308637.7150179459 300287.876210025 292771.3446939783 291256.57106952113 288273.99582814384 323704.897383267 356152.2344224472 0.8593236625660046 0.9422632462833971 0.9346301093120526 0.8665892985858897 0.8431447206753752 0.8220398930495263 0.8177867297163982 0.8094122904931993 0.9088947536948678 1.0 18.442134515910915 -4.398619885381339 14.134668302490622 0.8743959520322125 0.00014856996629799809 0.0 0.06033812116723181 524571.4817074308 525630.3822455697 0.015571576408244222 14539697.492184091 3.993743002957214e-05 4.398619885381339 -0.8742473820659146 AAPEAS(ph)SPPASPLQHLLPGK ddPTM_A459_Selumetinib_30min_R1 2 AAPEASSPPASPLQHLLPGK 20 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 AAPEAS(0.84)S(0.16)PPASPLQHLLPGK;AAPEAS(0.833)S(0.167)PPASPLQHLLPGK 177.29 2.6693e-13 1243620000.0 14143.699999999999 19383.1 16921.0 19874.8 19742.8 14506.5 16981.2 15279.7 5232.0 10824.6 True False 14473.220691150595 17113.71764104127 14623.221140399828 16404.039276201926 17957.06722587444 14360.577780848147 15700.294412357454 14874.432720539557 8878.32186983912 12214.042850532844 1.1849656062504474 1.4011509416224681 1.1972465889754007 1.3430474640496526 1.4701984793749971 1.1757431963014326 1.2854297798433318 1.2178140278827212 0.7268946063548318 1.0 13.576253191259887 -8.139190783455003 4.977193516843593 0.8687491449980902 1.2954117300477004 0.7067229913224125 0.10914590912907517 0.11158299537442652 3.942662353350618 0.07517578030667765 0.026943580932964242 7.257870526690911e-09 8.139190783455003 0.4266625850496102 AAPEAS(ph)SPPASPLQHLLPGK ddPTM_A459_Selumetinib_30min_R2 2 AAPEASSPPASPLQHLLPGK 20 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 AAPEAS(0.837)S(0.163)PPASPLQHLLPGK;AAPEAS(0.765)S(0.234)PPAS(0.001)PLQHLLPGK 153.83 3.4714e-06 720720000.0 355280.0 348010.0 429510.0 479800.0 466580.0 317130.0 301380.0 313130.0 320830.0 391840.0 True False 335534.9598985254 374701.24797148025 401875.79421513 414450.41229883325 407964.0491218772 360811.77888048784 315394.7671731403 314041.1564585376 385004.9647391871 380526.56107741426 0.8817648863945248 0.9846914415397434 1.0561044492591214 1.0891497590217296 1.072104002324508 0.9481907855758966 0.8288377197117035 0.8252805154241234 1.0117689646922223 1.0 18.537637633020474 -6.97310468829898 7.183358623643447 0.8999440690465198 1.020495313347601 0.25821621234904923 0.0789495034028503 0.21711322750676929 41.06393764330922 0.02935243420362119 0.025542551296091794 1.0638865335092736e-07 6.97310468829898 0.1205512443010811 AAPEASS(ph)PPAS(ph)PLQHLLPGK ddPTM_A459_Selumetinib_30min_R2 1 AAPEASSPPASPLQHLLPGK 20 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 2 AAPEAS(0.285)S(0.715)PPAS(1)PLQHLLPGK 135.29 0.007610600000000001 0.0 8313.8 8704.8 9529.3 10143.0 10880.0 7283.2 9788.7 10943.0 7687.6 10853.0 True False 7851.752278778313 9372.43016965646 8916.195212717352 8761.50590234905 9513.157131565911 8286.394689693092 10243.893945941072 10974.842318288827 9225.334809490936 10539.645690519537 0.744973076831321 0.8892547667031167 0.8459672625178959 0.8312903639853916 0.9026069197110718 0.7862118834930802 0.971939118898039 1.0412913906736687 0.8752983810251961 1.0 13.363538748505402 -7.278010674773449 23.389089804650478 0.9755732183880422 0.8395469203846262 0.5794747729861112 0.05773167353203201 255.01792784107863 359935.41532702494 0.022827108126732512 0.01545148268437387 5.2721690249657906e-08 7.278010674773449 -0.13602629800341604 AAPEASSPPAS(ph)PLQHLLPGK ddPTM_A459_Selumetinib_30min_R2 1 AAPEASSPPASPLQHLLPGK 20 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 AAPEAS(0.007)S(0.001)PPAS(0.991)PLQHLLPGK 103.31 0.00096923 0.0 23823.0 22621.0 20408.0 25353.0 23808.0 14953.0 20607.0 17372.0 21321.0 25147.0 True False 22499.01303102504 24355.957962020795 19094.971498550356 21899.877663635547 20817.026193779508 17012.6400201808 21565.266331995856 17422.549643910592 25585.795758514512 24420.94077024739 0.921300012259811 0.9973390538539053 0.7819097420609697 0.8967663395800332 0.8524252357690242 0.6966414676746483 0.8830645197038981 0.7134266369106016 1.0476990218856062 1.0 14.575831158024952 -5.253627454613751 24.70098301195947 0.8449329671728038 0.9593195361409325 0.11169863502224553 0.107472737005218 890.430025477585 2815483.523845257 0.025730671631906628 0.06534882273889049 5.576639176532534e-06 5.253627454613751 0.11438656896812871 AAPPPPALT(ph)PDSQTVDSSCK ddPTM_A459_Selumetinib_30min_R2 2 AAPPPPALTPDSQTVDSSCK 20 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 AAPPPPALT(0.657)PDS(0.294)QT(0.049)VDSSCK;AAPPPPALT(0.985)PDS(0.014)QT(0.001)VDSSCK 185.96 2.8436e-15 25398000.0 99655.0 85190.0 88032.0 103290.0 91773.0 66593.0 80711.0 87122.0 63057.0 81960.0 True False 94116.57405057304 91723.7990709764 82368.11696199459 89221.72381481164 80243.65527897043 75765.5812789339 84464.22142581241 87375.51059617639 75670.16195978853 79593.60184234615 1.1824640658553567 1.152401662292617 1.0348585194717537 1.1209660292988908 1.008167156926908 0.9519054236169064 1.0611936069071692 1.0977705314711619 0.9507065920910462 1.0 16.280364843467744 -4.881500724774547 0.7494291960569583 1.0181293272741991 1.2787617045472555 0.557797482950018 0.051109513582224646 1.995235947866374 0.9383608302525274 0.021610325593670706 0.4282900996374584 1.3137093025678066e-05 4.881500724774547 0.2606323772730563 AAPPPPPPPPPLES(ph)SPR ddPTM_A459_Selumetinib_30min_R1 4 AAPPPPPPPPPLESSPR 17 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR 184.92 5.9589e-08 252355000.0 2905.04 3019.23 3295.02 3731.2200000000003 3209.58 2883.1099999999997 2884.4800000000005 2587.45 1359.5 2553.35 True False 2972.72177977616 2665.737147998052 2847.5743822492905 3079.6324706739274 2919.2740556973713 2854.10853105443 2666.9013512918295 2518.8224207779003 2306.9722060486006 2881.097344235172 1.0318019228764765 0.9252506352595002 0.9883645160227029 1.0689095517150808 1.0132507537583164 0.99063245355637 0.9256547185495381 0.8742580065258286 0.8007269211728141 1.0 11.492402690620755 -7.397704756755814 2.5318826412504256 0.8792796207377797 1.003432957807615 0.4433771672695379 0.05694952323233954 0.25733802617231066 3.2116150291367807 0.028603125825671795 0.01718474339937274 4.0021673371783755e-08 7.397704756755814 0.12415333706983545 AAPPPPPPPPPLES(ph)SPR ddPTM_A459_Selumetinib_30min_R2 6 AAPPPPPPPPPLESSPR 17 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR;AAPPPPPPPPPLES(0.5)S(0.5)PR 181.69 7.254800000000001e-08 134576100.0 219731.1 180133.3 227736.3 237510.7 232033.2 174003.2 182101.9 181752.0 155919.9 224922.7 True False 207519.32511528645 193948.94489015036 213083.9943985358 205161.33293118974 202883.11501287276 197970.56135621763 190569.99917806927 182280.8682293366 187108.23676600598 218428.59723164293 0.9500556600435097 0.887928354383323 0.9755315791940962 0.9392604060612847 0.9288303710421021 0.9063399383839397 0.8724590167832754 0.8345100895192228 0.8566105314844751 1.0 17.736802224391532 -6.943647914905455 2.549705207386764 0.8775386297946915 0.9365336068358768 0.1556865928826877 0.04631222006194565 0.4012468319892197 5.287376995820097 0.017986686540715887 0.014899324521514122 1.138549940915285e-07 6.943647914905455 0.05899497704118528 AAPQS(ph)PSVPK ddPTM_A459_Selumetinib_30min_R1 5 AAPQSPSVPK 10 0 E9PF10;O75694-2;O75694 E9PF10 NUP155 Nuclear pore complex protein Nup155 1 AAPQS(0.63)PS(0.37)VPK;AAPQS(0.923)PS(0.077)VPK;AAPQS(0.976)PS(0.024)VPK;AAPQS(0.938)PS(0.062)VPK;AAPQS(0.614)PS(0.386)VPK 160.72 0.00043736 457401700.0 24231.600000000002 28228.5 26379.6 27775.5 25751.9 23354.3 24575.5 24891.7 13288.0 20749.0 True False 24796.149133514176 24923.494096926373 22797.395212770585 22925.030335708878 23422.64519186723 23119.376946007775 22721.750249151428 24231.491256363304 22548.765482878865 23412.336262375153 1.0591061419770773 1.0645453669217853 0.9737343149904775 0.9791859333812234 1.0004403204095715 0.9874869678495871 0.9705033275840339 1.0349881782325405 0.9631147114145934 1.0 14.514981284352617 -5.255167214025753 24.836981336690897 0.9893202134923925 1.0618257651943943 0.6965439784449536 0.019307664496148496 232.8730709664353 922142.3761396658 0.004725105851841939 0.011880995826031382 5.5569026169830845e-06 5.255167214025753 0.07250555170200179 AAPQS(ph)PSVPK ddPTM_A459_Selumetinib_30min_R2 2 AAPQSPSVPK 10 0 E9PF10;O75694-2;O75694 E9PF10 NUP155 Nuclear pore complex protein Nup155 1 AAPQS(0.698)PS(0.302)VPK;AAPQS(0.739)PS(0.261)VPK 119.39 0.005416300000000001 260960000.0 1342220.0 1191560.0 1451650.0 1472610.0 1438050.0 1120020.0 1143310.0 1235430.0 887950.0 1226580.0 True False 1267624.7857323769 1282948.8205307212 1358252.4194370182 1272037.9776060577 1257389.3026698856 1274292.5884707344 1196476.180425786 1239024.8967635545 1065564.8113959448 1191165.4483624278 1.0641886796456888 1.0770534204920685 1.140271841585311 1.0678936157481822 1.0555958489213233 1.0697863930007263 1.0044584336043823 1.0401786741438162 0.8945565142615962 1.0 20.183942381312562 -7.507411647846889 1.0288830479566735 0.9599156845602197 1.08681210427738 0.6161312062679727 0.038151967183400505 0.35212589969195446 0.6911724402277668 0.029742564561185073 0.014011638819166648 3.1087682811040636e-08 7.507411647846889 0.12689641971716026 AAPS(ph)TAPAEATPPKPGEAEAPPK ddPTM_A459_Selumetinib_30min_R2 1 AAPSTAPAEATPPKPGEAEAPPK 23 1 O95817 O95817 BAG3 BAG family molecular chaperone regulator 3 1 AAPS(0.418)T(0.418)APAEAT(0.164)PPKPGEAEAPPK 58.93 0.0073831 8535700.0 25420.0 22250.0 20831.0 25834.0 23810.0 22639.0 31042.0 26797.0 21166.0 20807.0 True False 24007.258164322542 23956.503454973838 19490.756139077916 22315.364633864287 20818.774935899277 25757.31675361955 32485.514508556065 26874.974833517837 25399.791427452667 20206.247846921582 1.1881106450933712 1.1855988126278283 0.964590570537188 1.1043794376333966 1.0303137471943369 1.2747204205724751 1.6076965280570499 1.3300329203678571 1.2570266196810171 1.0 14.302513828174328 -6.889481285318754 5.511891333026986 1.341108524824422 1.0941467388429964 0.2824866166560337 0.15278425034207765 0.22855133720737608 10.215340274165985 0.05383864910189373 0.04744290427574174 1.2897891364830929e-07 6.889481285318754 -0.2469617859814257 AAPSTAPAEAT(ph)PPKPGEAEAPPK ddPTM_A459_Selumetinib_30min_R1 2 AAPSTAPAEATPPKPGEAEAPPK 23 1 O95817 O95817 BAG3 BAG family molecular chaperone regulator 3 1 AAPST(0.002)APAEAT(0.998)PPKPGEAEAPPK;AAPST(0.001)APAEAT(0.999)PPKPGEAEAPPK 113.52 1.6841e-05 45257000.0 7272.7 10145.8 5945.3 6581.299999999999 5852.799999999999 6582.400000000001 6996.5 7740.9 4031.46 7726.400000000001 True False 7442.13975978923 8957.925019345543 5137.960915195262 5431.999501301538 5323.415273395765 6516.187032341012 6468.748372085532 7535.5861860131145 6841.093173811468 8718.158701509241 0.8536366467498334 1.0275019446244762 0.5893401452196328 0.6230672883210051 0.6106123386437327 0.7474269803339282 0.7419856180142369 0.8643552433507082 0.7846947283291796 1.0 13.089807750776162 -8.754830392077581 0.8873326791935593 0.996845940162342 0.7399568502126331 0.2573245787190558 0.12613120097850578 1.408870850069845 2.203806764226288 0.13463644002821593 0.045758820412364204 1.758610281675445e-09 8.754830392077581 -0.2568890899497088 AAPSTAPAEAT(ph)PPKPGEAEAPPK ddPTM_A459_Selumetinib_30min_R2 2 AAPSTAPAEATPPKPGEAEAPPK 23 1 O95817 O95817 BAG3 BAG family molecular chaperone regulator 3 1 AAPS(0.001)T(0.002)APAEAT(0.997)PPKPGEAEAPPK;AAPS(0.004)T(0.003)APAEAT(0.993)PPKPGEAEAPPK 114.21 1.576e-05 43334000.0 73472.0 61124.0 67554.0 74546.0 74131.0 58187.0 87619.0 86581.0 63470.0 59078.0 True False 69388.72037171938 65812.01425536272 63207.64918723388 64392.70620097723 64818.001040451454 66201.73108100446 91693.45711375473 86832.93637574374 76165.77349997274 57372.264636921886 1.2094471224178296 1.1471050458239964 1.101710897891882 1.1223664711247487 1.1297793707577977 1.153897819790791 1.5982192387564471 1.5135002413668444 1.32757132705123 1.0 15.80806584569993 -7.148263910798328 8.83600052977762 1.4022829523083151 1.1394867918949076 0.31726304752143775 0.14999852792909263 0.3163187073315708 22.61199251366107 0.05482776940682028 0.04245906571159106 7.107814567979464e-08 7.148263910798328 -0.2627961604134075 AAPSTAPAEAT(ph)PPKPGEAEAPPKHPGVLK ddPTM_A459_Selumetinib_30min_R1 2 AAPSTAPAEATPPKPGEAEAPPKHPGVLK 29 2 O95817 O95817 BAG3 BAG family molecular chaperone regulator 3 1 AAPS(0.214)T(0.053)APAEAT(0.733)PPKPGEAEAPPKHPGVLK;AAPS(0.035)T(0.1)APAEAT(0.865)PPKPGEAEAPPKHPGVLK 70.316 0.00041933 31651600.0 4500.16 4409.8 6590.8 7030.1 4528.35 4143.26 4265.87 4764.5 2624.54 3699.15 True False 4605.004972212945 3893.4985659395998 5695.80556067296 5802.425006320926 4118.761542045129 4101.582566179086 3944.0919914283595 4638.129982722874 4453.652691182634 4173.971935272302 1.103266874723853 0.9328042033626168 1.3646008284196516 1.3901447101949396 0.9867726965865258 0.9826569583562632 0.9449253738624034 1.1112029631843443 1.0670059023509189 1.0 12.02720518487723 -6.336444229691559 24.999972062179584 1.0158235952013137 1.1907107136354966 0.32780254236614104 0.1277152626039722 179.66524474337388 59883.403407398175 0.04352804732981851 0.049356171199801846 4.6084594482855244e-07 6.336444229691559 0.17488711843418292 AAPT(ph)TPPPPVK ddPTM_A459_Selumetinib_30min_R2 1 AAPTTPPPPVK 11 0 C9JC20;C9JMQ4;C9JSC3;Q9NZQ3-5;Q9NZQ3-4;Q9NZQ3-3;Q9NZQ3-2;Q9NZQ3 C9JC20 NCKIPSD NCK-interacting protein with SH3 domain 1 AAPT(0.971)T(0.029)PPPPVK 117.25 0.01322 19071000.0 65033.0 54599.0 65169.0 59804.0 75174.0 40882.0 55398.0 55429.0 45389.0 57612.0 True False 61418.72620772578 58786.567736544515 60976.09749064228 51658.5920323457 65729.9700559131 46513.12441015388 57974.11676905451 55590.28921323505 54468.06827462201 55948.591866047325 1.0977707241457497 1.0507247059459852 1.0898593772767662 0.9233224699564775 1.1748279601617937 0.8313546929208883 1.036203322290161 0.9935958593261807 0.9735377863491186 1.0 15.771814200948883 -5.504849110870166 0.7006455337268408 0.9830737409305152 1.1095874041261902 0.16055290304903425 0.08407895816875147 2.6019133972273942 1.813102006509651 0.039856953514936726 0.22674367057999636 3.12716566539785e-06 5.504849110870166 0.12651366319567492 AAPTT(ph)PPPPVK ddPTM_A459_Selumetinib_30min_R1 2 AAPTTPPPPVK 11 0 C9JC20;C9JMQ4;C9JSC3;Q9NZQ3-5;Q9NZQ3-4;Q9NZQ3-3;Q9NZQ3-2;Q9NZQ3 C9JC20 NCKIPSD NCK-interacting protein with SH3 domain 1 AAPT(0.021)T(0.979)PPPPVK;AAPT(0.028)T(0.972)PPPPVK 107.11 0.025098 31827000.0 6896.9 7758.8 6859.4 7283.099999999999 7640.7 5538.2 6729.8 6401.1 3078.3 6408.8 True False 7057.58435096873 6850.396089031736 5927.931155987148 6011.243305719114 6949.6000340751525 5482.490736283268 6222.165767806937 6231.322034296863 5223.650269863484 7231.431906998398 0.9759594561263278 0.9473083861029093 0.8197451393064 0.8312659765075827 0.9610268233805126 0.758147322244361 0.8604334311418022 0.8616996072750608 0.7223535168474956 1.0 12.82006563039802 -5.16377102190457 4.832097015858029 0.8471597342303695 0.9682462180773459 0.23931002080131936 0.07837103164869298 0.28632402041448374 10.711612162039282 0.019026077635924378 0.05429103036590018 6.858497396211134e-06 5.16377102190457 0.1210864838469764 AAPWGSNPS(ph)PSAESTQAMDR ddPTM_A459_Selumetinib_30min_R1 2 AAPWGSNPSPSAESTQAMDR 20 0 Q96N67-2;Q96N67-6;Q96N67;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 AAPWGSNPS(0.928)PS(0.069)AES(0.001)T(0.001)QAMDR;AAPWGSNPS(0.772)PS(0.228)AESTQAMDR 260.98 1.2032999999999995e-47 22021300.0 1165.03 1237.78 1632.85 1838.83 1273.04 1277.1799999999998 1359.25 1307.1 540.77 941.23 True False 1192.172932246242 1092.860142171689 1411.117938603029 1517.712859614105 1157.893756773467 1264.3327287866566 1256.7206781615469 1272.4314619408274 917.6471937218839 1062.0460388565878 1.122524719860309 1.029013905412496 1.3286786890352291 1.4290462033530051 1.0902481760772538 1.1904688521298505 1.1833015068862254 1.1980944473092177 0.8640371134097299 1.0 10.052630591849764 -8.252080640041953 24.453734643160985 0.9320185561337254 1.198829574014041 0.47042921248888636 0.11218944948267064 396.91587696834125 1037122.41728602 0.08287908178884014 0.030338276581083474 5.596536750398999e-09 8.252080640041953 0.2668110178803157 AAPWGSNPS(ph)PSAESTQAMDR ddPTM_A459_Selumetinib_30min_R2 3 AAPWGSNPSPSAESTQAMDR 20 0 Q96N67-2;Q96N67-6;Q96N67;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 AAPWGSNPS(0.608)PS(0.391)AES(0.001)TQAMDR;AAPWGSNPS(0.591)PS(0.396)AES(0.012)T(0.002)QAMDR;AAPWGSNPS(0.591)PS(0.404)AES(0.004)T(0.001)QAMDR 169.6 2.1944e-09 40167000.0 43099.0 35733.5 54455.0 46955.0 51947.0 34336.0 37280.0 40493.0 28593.3 37458.0 True False 40703.73011896686 38474.144548687975 50951.424586121066 40559.647998107015 45420.953447927765 39065.47232882551 39013.5938689186 40610.82792602296 34312.75896355391 36376.49021242798 1.1189570483922189 1.0576651107352664 1.4006690664376844 1.1149961901560768 1.2486348513197063 1.0739208785865448 1.072494725057055 1.1164031408436519 0.9432674445274272 1.0 15.15071873074678 -7.540548859229406 0.9372544987462277 0.9891206727874813 1.1865589889945136 0.372917672820145 0.09665555313367397 0.648210449127413 1.049878645870883 0.08129163605877356 0.038296901315121396 2.8803889804889232e-08 7.540548859229406 0.19743831620703234 AAPWGSNPSPS(ph)AESTQAMDR ddPTM_A459_Selumetinib_30min_R1 2 AAPWGSNPSPSAESTQAMDR 20 0 Q96N67-2;Q96N67-6;Q96N67;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 AAPWGSNPS(0.205)PS(0.753)AES(0.035)T(0.008)QAMDR;AAPWGS(0.002)NPS(0.24)PS(0.741)AES(0.017)T(0.001)QAMDR 174.65 2.8447000000000005e-10 22798600.0 1837.4499999999998 1737.77 2117.88 2128.86 2395.7 1751.3600000000001 2115.6400000000003 1768.72 1051.0900000000001 1718.1399999999999 True False 1880.259009944686 1534.3110805326453 1830.2835286821096 1757.0945646514797 2179.0093579951867 1733.7429085076506 1956.055571488464 1721.8077999877428 1783.6229614237761 1938.6800051008336 0.9698655812189547 0.7914204904861767 0.9440874841987726 0.9063355272806306 1.1239654570439814 0.8942903954990118 1.0089625757432448 0.8881340888942573 0.9200192691578347 1.0 10.920858979209422 -5.672915837116008 2.636912741103404 0.9657653015172254 0.8812219184025458 0.1368779519673471 0.07843349371483145 0.4924922941133304 6.9093182533281725 0.02208262081172281 0.04290110844407316 2.12365597009227e-06 5.672915837116008 -0.08454338311467957 AAPWGSNPSPS(ph)AESTQAMDR ddPTM_A459_Selumetinib_30min_R2 1 AAPWGSNPSPSAESTQAMDR 20 0 Q96N67-2;Q96N67-6;Q96N67;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 AAPWGSNPS(0.412)PS(0.552)AES(0.028)T(0.007)QAMDR 187.63 1.3097000000000004e-15 16055000.0 11331.0 12307.0 19065.0 20872.0 18509.0 18092.0 20577.0 12927.0 12744.0 17168.0 True False 10701.268381586893 13250.907326757875 17838.378656402518 18029.19759379171 16183.733947440573 20584.008777175874 21533.871272551987 12964.615429819953 15293.156097111249 16672.31523217907 0.6418585680849221 0.7947850758713122 1.0699401017785966 1.0813853590648126 0.9706950547698684 1.2346220960030125 1.2915945369716664 0.7776133817813784 0.9172784873689337 1.0 14.025166840325655 -5.085167925822176 2.851814594145142 1.0501331140734067 0.6510600990435629 0.4758770496441277 0.14005949746219665 0.2581968557062755 3.85416949223409 0.04006572464483172 0.168960297957036 8.219247801886875e-06 5.085167925822176 -0.3990730150298438 AAQDRDQIYR ddPTM_A459_Selumetinib_30min_R1 1 AAQDRDQIYR 10 1 P62995;H7C2L4;P62995-3 P62995 TRA2B Transformer-2 protein homolog beta 0 107.21 0.011229 0.0 1950.0 2285.4 2808.8 2907.3 2799.1 2207.8 2333.4 2060.9 1300.5 1964.2 False True 1995.4312059605074 2017.8243055463643 2427.3803876340075 2399.594631780037 2545.921899221244 2185.5915365220117 2157.389759368883 2006.2382372533473 2206.8535152381046 2216.3242029282014 0.900333625975906 0.910437337137058 1.0952280286552658 1.0826911643204993 1.1487136655628176 0.9861334969109727 0.9734089247947325 0.9052097317724144 0.9957268491326385 1.0 11.11395321828101 -10.123603537161621 11.722471240006767 1.000000255151947 1.0028079653511963 0.0 0.08121729434553124 0.0 0.0 0.08746357552705232 0.021213032958366157 7.523093558913884e-11 10.123603537161621 0.0028077101992494136 AAQDRDQIYR ddPTM_A459_Selumetinib_30min_R2 1 AAQDRDQIYR 10 1 P62995;H7C2L4;P62995-3 P62995 TRA2B Transformer-2 protein homolog beta 0 102.06 0.044218 11438000.0 40367.0 41488.0 41501.0 51469.0 56161.0 30888.0 33219.0 32372.0 28262.0 56885.0 False True 38123.56374190436 44669.99619505409 38830.8708428723 44458.833411022715 49105.55309428981 35142.541626653125 34763.74932219975 32466.197160526885 33915.1897062585 55242.58224502016 0.690111906297447 0.8086152815400092 0.7029155637700608 0.8047928175014023 0.8889076342682447 0.6361495100063149 0.6292926201025574 0.587702381770062 0.6139320127330902 1.0 15.753493137686583 -6.793769224109441 24.99672874757299 0.6636389886511725 0.7779086398038921 0.08449041468604512 0.12273138795462854 341.8452657308513 264304.96300005517 0.04105708877645244 0.03621172730546455 1.607795378177289e-07 6.793769224109441 0.11426965115271959 AAQEEYVKR ddPTM_A459_Selumetinib_30min_R1 3 AAQEEYVKR 9 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;; 164.46 0.013652 49789000.0 5774.18 5763.139999999999 8028.1 8821.7 7800.83 6472.81 6362.85 6029.5599999999995 4439.9 5365.13 False True 5908.707159401565 5088.388889588904 6937.928115196731 7281.155698818129 7095.246303848395 6407.699408241253 5882.895101740074 5869.636482028869 7534.1860225341525 6053.796696291714 0.9760332987430805 0.8405285385130002 1.1460457731338412 1.2027420252282737 1.1720324714892765 1.0584596295026432 0.9717695186796863 0.9695793857141497 1.2445389894162218 1.0 12.563624510838961 -5.26462117918658 24.972581058494086 1.095360230811641 0.9082809148781097 0.37663366853606617 0.09641799863454054 275.58394437473066 2162960.3748370865 0.026499372911183375 0.05915244505422908 5.437243976412186e-06 5.26462117918658 -0.18707931593353133 AAQGDVELLS(ph)HLPDQR ddPTM_A459_Selumetinib_30min_R1 1 AAQGDVELLSHLPDQR 16 0 H0YG18;Q96KJ4 H0YG18 MSLNL Mesothelin-like protein 1 AAQGDVELLS(1)HLPDQR 81.51 0.014206 7482100.0 2032.9 1312.8 1684.4 1886.5 1454.1 1785.4 1245.5 1192.6 1053.9 1130.7 True False 2080.2626146651883 1159.0967656958373 1455.6677317469102 1557.0581889908294 1322.576911742206 1767.4404970134967 1151.550932242197 1160.968373889243 1788.3913261894952 1275.8363589506762 1.63050895992345 0.9084995560474132 1.1409517541451304 1.220421551766597 1.0366352255629179 1.3853191160558749 0.9025851349692692 0.9099665217599634 1.4017403671269995 1.0 10.31722758298902 -4.74792842106175 24.98563316729737 1.1035699150636273 1.6305102621181662 0.445414738114319 0.1773348870827846 631.0468929778718 1166918.3893516455 0.042655235907835966 0.8216235156620362 1.7867820419191317e-05 4.74792842106175 0.5269403470545388 AAQMHS(ph)GYQR ddPTM_A459_Selumetinib_30min_R2 1 AAQMHSGYQR 10 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 AAQMHS(1)GYQR 81.494 0.032794 0.0 7592.0 7822.5 7169.6 8742.4 8742.7 6266.4 6392.4 6799.5 5978.8 7120.9 True False 7170.0670331839865 8422.460596698098 6708.315741670254 7551.670038518814 7644.363865270338 7129.539719284485 6689.659266300299 6819.285419282182 7174.727061629687 6915.301114679866 1.036840900241249 1.2179456045404617 0.9700684945489616 1.0920233137047435 1.10542747719876 1.0309803725176667 0.9673706401734883 0.9861154715021938 1.0375147723356701 1.0 12.755576357035295 -6.945894382762489 4.583241214220799 0.9966357451770644 1.085511911509182 0.31642018777104974 0.06031716568554294 0.24545334534169028 10.848324858364993 0.021532151667610216 0.018602655075359492 1.1326757882002476e-07 6.945894382762489 0.08887616633211759 AAQQAASSSGQGQQAQT(ph)PTGK ddPTM_A459_Selumetinib_30min_R2 1 AAQQAASSSGQGQQAQTPTGK 21 0 H0Y9X2;U3KQK7;U3KPX3;A0A590UJ43;P48729;P48729-2 H0Y9X2 CSNK1A1 Casein kinase I isoform alpha 1 AAQQAASSSGQGQQAQT(0.995)PT(0.005)GK 108.12 0.00017161 1668000.0 12929.0 11702.0 12696.0 15346.0 15551.0 12698.0 13463.0 14425.0 10169.0 15226.0 True False 12210.457938887743 12599.505772139486 11879.153182359625 13255.848326673413 13597.344352296086 14447.034239032684 14089.056176428405 14466.974361812698 12203.084145599847 14786.38581810104 0.8257905676950533 0.8521017865444548 0.8033845003433855 0.8964900882300806 0.9195853888548366 0.9770497278210519 0.9528397506834303 0.9783982739110372 0.825291879687138 1.0 13.851981842433364 -6.043343317177731 2.4003443168158674 0.9443186366477309 0.8295909752512899 0.5463809074623631 0.046609962651480194 0.22360799842798987 2.5622755183713113 0.014252785436268085 0.021123906976165358 9.05016886794955e-07 6.043343317177731 -0.11472766139644097 AAQQQQPSAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AAQQQQPSASPR 12 0 Q86U86-8;Q86U86 Q86U86-8 PBRM1 Protein polybromo-1 1 AAQQQQPSAS(1)PR;AAQQQQPSAS(1)PR 228.7 7.203e-10 17185300.0 2479.0699999999997 3225.6 3076.04 3480.3 3473.56 2857.6000000000004 2996.83 2547.89 1288.29 2240.29 True False 2536.8275075694964 2847.945252459243 2658.3306634782516 2872.5309383221743 3159.3771113068265 2828.855138493206 2770.776700338325 2480.31168048689 2186.1340370212233 2527.853043772538 1.0035502316161407 1.12662611439192 1.051615982988865 1.136352030193671 1.2498262583301953 1.1190742062566486 1.0960988049381426 0.9811929877004646 0.8648184839727323 1.0 11.303696879829344 -7.815432207467816 3.1401331114903197 0.9294644636424396 1.1185122171107673 0.5617061225830173 0.06691946754970934 0.18290213755500384 3.609712758088621 0.04290620621939802 0.019066822024374284 1.52956448985556e-08 7.815432207467816 0.1890477534683277 AAQQQQPSAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 AAQQQQPSASPR 12 0 Q86U86-8;Q86U86 Q86U86-8 PBRM1 Protein polybromo-1 1 AAQQQQPS(0.001)AS(0.999)PR;AAQQQQPSAS(1)PR;AAQQQQPSAS(1)PR 175.88 0.00010348 43720200.0 14041.8 14420.300000000001 17391.6 16388.100000000002 15411.7 14435.609999999999 12629.599999999999 12450.2 11043.7 17091.2 True False 13261.412969779092 15526.290641427375 16272.643390542347 14156.012508950647 13475.544463653885 16423.984244079595 13216.901425077622 12486.428020758438 13252.748586759852 16597.732647729437 0.7989894313421929 0.935446483622651 0.9804136345555872 0.8528883317618196 0.8118906810742812 0.9895317988705156 0.7963076466884582 0.7522972134670801 0.7984674092562168 1.0 14.018698553573905 -7.324770187136452 24.999933447561727 0.816126096899979 0.8949153244212937 0.07919339372593004 0.08622906898106333 413.37256052703185 163177.5444360895 0.03523741808968772 0.023757067172410794 4.734016996761483e-08 7.324770187136452 0.07878922752131479 AARQLMERT(ph)QSSNMETRLDAMK ddPTM_A459_Selumetinib_30min_R1 1 AARQLMERTQSSNMETRLDAMK 22 3 Q5JVZ5;Q96JJ3;Q5JVZ4 Q5JVZ5 ELMO2 Engulfment and cell motility protein 2 1 AARQLMERT(0.946)QS(0.018)S(0.018)NMET(0.018)RLDAMK 49.902 0.036916 0.0 554.86 665.39 781.26 1007.9 642.48 633.2 740.21 566.64 569.12 561.87 True False 567.7871584303834 587.485829468581 675.1691831539956 831.8891856262161 584.367797439057 626.8305828996001 684.3753637535101 551.6108664938796 965.7550731198087 633.9914875772671 0.8955753658461936 0.926646242071163 1.0649499187033014 1.3121456706070211 0.9217281444458475 0.9887050460172082 1.0794709032589378 0.8700603672169219 1.5232934385449588 1.0 9.308319659614947 -8.243569232176188 24.894400477676196 1.2616468417095805 1.0157163686787336 0.2656048170239361 0.16864857498155217 903.5091097146936 1258658.2012118222 0.11095288991731724 0.04173189773124093 5.707300871374769e-09 8.243569232176188 -0.24593047303084692 AAS(ph)ADYLRPR ddPTM_A459_Selumetinib_30min_R1 2 AASADYLRPR 10 1 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B0QYZ7 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 AAS(1)ADYLRPR;AAS(1)ADYLRPR 133.42 0.010795 46009000.0 10191.1 11419.8 11840.8 12982.4 12588.2 9903.4 11216.8 10414.3 5650.5 8699.3 True False 10428.53280157135 10082.764507079013 10232.884396858712 10715.26754983013 11449.599532627224 9803.780787567754 10370.70774530251 10138.078933586072 9588.485803808466 9815.93989335776 1.0624079726311404 1.0271827880590232 1.0424762690104785 1.0916191079247466 1.1664292627112487 0.9987612897061203 1.0565170384060878 1.0328179515897706 0.9768280885966705 1.0 13.260910699532895 -7.860930668220338 1.32858284626206 0.9887177456176918 1.0680540896214852 0.33275733037039457 0.04215622629997346 0.5701705918041441 1.8216491011476472 0.0385104555902062 0.014040193570209495 1.3774293473623691e-08 7.860930668220338 0.07933634400379341 AAS(ph)ADYLRPR ddPTM_A459_Selumetinib_30min_R2 4 AASADYLRPR 10 1 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B0QYZ7 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 AAS(1)ADYLRPR;AAS(1)ADYLRPR;AAS(0.999)ADY(0.001)LRPR;AAS(1)ADYLRPR 114.76 0.0037711 69091500.0 202781.0 186378.0 202471.0 231283.0 232196.0 164141.0 169246.0 174374.0 164614.0 181808.0 True False 191511.24381665993 200672.59330027466 189444.23629375637 199781.8564145715 203025.4626214223 186749.9328263555 177116.27435458667 174881.39947083022 197541.39969945658 176558.7306460864 1.0846886082373688 1.1365770050903046 1.0729814130432276 1.1315320159105362 1.1499032751225922 1.0577213154114564 1.0031578370917147 0.9904998684057239 1.1188424326375008 1.0 17.42978863707149 -6.949188323590277 5.69179368671097 1.027598292082185 1.114544302789497 0.5210454146150824 0.0396606298873032 0.15423970336832626 11.091182130590331 0.013963544152288319 0.01218353823294136 1.1241174160021984e-07 6.949188323590277 0.08694601070731212 AAS(ph)APT(ph)AS(ph)S(ph)SSKTT(ph)WPR ddPTM_A459_Selumetinib_30min_R2 1 AASAPTASSSSKTTWPR 17 1 Q9BV86-2 Q9BV86-2 5 AAS(0.988)APT(0.99)AS(0.996)S(0.492)S(0.492)S(0.04)KT(0.01)T(0.992)WPR 54.768 0.028069 4848200.0 3343.5 1603.2 12756.0 24547.0 34498.0 25803.0 13504.0 25782.0 55990.0 10422.0 True False 3157.6816550909716 1726.1602848995076 11935.29284768269 21203.656254063117 30164.052823966984 29357.129033687237 14131.962757668365 25857.021351560117 67189.56449131039 10121.089780392029 0.3119902820354848 0.1705508322081742 1.1792497751383832 2.094997348520884 2.9803166930111566 2.9005897260749447 1.3962886472014855 2.554766523428525 6.638570148985268 1.0 13.305077019000683 -5.710310304876654 1.3798919487661196 2.948583288493851 0.1074280019888135 0.36656262315739463 1.4167905724626926 0.5052842554106786 1.9026113285812614 0.4747920593728171 1.2285646441110036 1.9484519267886944e-06 5.710310304876654 -2.8411552865050376 AAS(ph)DDGSLK ddPTM_A459_Selumetinib_30min_R2 1 AASDDGSLK 9 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5;A0A1B0GV45 Q92614;A0A1B0GV45 MYO18A Unconventional myosin-XVIIIa 1 AAS(1)DDGSLK 82.417 0.041393 4931700.0 26248.0 23941.0 30205.0 31084.0 27687.0 23152.0 40352.0 96787.0 34550.0 49740.0 True False 24789.24123906919 25777.197717551837 28261.643184717414 26850.305577109128 24208.71153507952 26340.97784706921 42228.44795597109 97068.63414604963 41460.96540765805 48303.876959959605 0.5131936150718847 0.533646558824238 0.5850802246814321 0.5558623296296915 0.5011753312295569 0.5453180884197756 0.8742248161772893 2.0095412678057385 0.8583361836985914 1.0 15.559851366673401 -7.529717865490547 24.990490538699007 1.34874001309297 0.5540889496608712 0.5819720162838147 0.2836731417689572 105.48669816291586 385446.7792679464 0.12278889234992961 0.07109950882883723 2.953127069323091e-08 7.529717865490547 -0.7946510634320989 AAS(ph)DSNPAGPLR ddPTM_A459_Selumetinib_30min_R1 3 AASDSNPAGPLR 12 0 Q9BUU2-2;Q9BUU2 Q9BUU2-2 METTL22 Methyltransferase-like protein 22 1 AAS(0.619)DS(0.381)NPAGPLR;AAS(0.69)DS(0.31)NPAGPLR;AAS(0.996)DS(0.004)NPAGPLR 157.5 0.00044524 22348600.0 4982.799999999999 5097.3 6014.4 5895.0 5795.200000000001 4656.799999999999 5221.7 4813.0 3198.38 4202.799999999999 True False 5098.889545158987 4500.505746329522 5197.677514734395 4865.548912854994 5271.025183225664 4609.956820036101 4827.822964985215 4685.343605172675 5427.417259567286 4742.270318738743 1.0752001051081141 0.9490192342149063 1.0960314712968053 1.0259956910573242 1.1114982548332564 0.9720991234557391 1.018040440653165 0.9879958944261092 1.1444765681368338 1.0 12.211362186281798 -7.849112813022739 0.002757732237160004 0.589759241210356 1.479567579611551 0.003662102524565003 0.06172366484063345 231161.24315305267 638.725964038845 102976.58431283869 103101.71929342663 1.415426058883512e-08 7.849112813022739 0.8898083384011951 AAS(ph)DSNPAGPLR ddPTM_A459_Selumetinib_30min_R2 2 AASDSNPAGPLR 12 0 Q9BUU2-2;Q9BUU2 Q9BUU2-2 METTL22 Methyltransferase-like protein 22 1 AAS(0.917)DS(0.083)NPAGPLR;AAS(0.878)DS(0.122)NPAGPLR 131.35 0.0020376 22434000.0 49001.0 43114.0 53926.0 51219.0 53202.0 36807.0 37976.0 43263.0 41272.0 41601.0 True False 46277.72058654481 46420.70516664007 50456.459870189436 44242.88384229676 46518.289128085395 41876.83014932086 39741.95924801639 43388.88816742479 49527.553236030755 40399.87103762122 1.14549178989829 1.1490310234755978 1.248926260759677 1.095124382973818 1.151446475776286 1.0365585105537654 0.9837150027287918 1.0739858086928082 1.225933448894172 1.0 15.302063067237379 -6.399878685789915 1.879648439814764 1.0662105682763778 1.1709146828686896 0.2854961037879381 0.07181993798691153 0.4671341075688551 3.2709745353081177 0.026773550287694573 0.03177066363241632 3.982183918675745e-07 6.399878685789915 0.10470411459231177 AAS(ph)EELLEK ddPTM_A459_Selumetinib_30min_R1 3 AASEELLEK 9 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AAS(1)EELLEK;AAS(1)EELLEK;AAS(1)EELLEK 163.9 0.0008675000000000001 99053600.0 9271.9 10694.3 11977.4 13251.2 10543.8 9528.300000000001 10419.4 9565.7 5155.9 7632.5 True False 9487.917230023198 9442.20638435481 10350.9348671488 10937.126675831052 9590.115151659083 9432.453953004197 9633.45626929293 9311.986562227345 8749.185727963204 8612.20572184579 1.1016826044872652 1.096374922907802 1.2018912693751074 1.2699565046487276 1.113549241785147 1.0952425264386982 1.1185817641184101 1.0812545430268212 1.01590533372536 1.0 13.072167066585012 -7.865517902788027 0.858805932018155 0.997291088995878 1.158420961842604 0.544753320232988 0.05065610771897557 0.5064649638026787 0.6997972568717689 0.051712567076202864 0.02152420691871895 1.3629568202994184e-08 7.865517902788027 0.16112987284672597 AAS(ph)EELLEK ddPTM_A459_Selumetinib_30min_R2 4 AASEELLEK 9 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AAS(1)EELLEK;AAS(1)EELLEK;AAS(1)EELLEK;AAS(1)EELLEK 147.28 0.0016555999999999995 71532800.0 127687.0 111589.0 121512.0 124290.0 119129.0 90424.0 101961.0 95475.0 82009.6 121701.0 True False 120590.66771156006 120147.51748481243 113694.05021226213 107361.4875877908 104162.94999322745 102879.0852126549 106702.38853188853 95752.81644326299 98413.81153967799 118187.17591282794 1.0203363163572408 1.0165867536544777 0.9619829675608813 0.9084021744201596 0.8813388524492334 0.8704758736983113 0.9028254352281815 0.8101794099377414 0.8326945015782904 1.0 16.85071397652853 -5.6337047991348985 1.3596703531931396 0.8722155622375583 1.0284628115923136 0.5593380280933974 0.04769204399366474 0.3218023466097248 1.1452282868463202 0.015262727323494797 0.04469208317531688 2.32431615558907e-06 5.6337047991348985 0.1562472493547553 AAS(ph)GEDSTEEALAAAAAPWEGGPVPGVDR ddPTM_A459_Selumetinib_30min_R1 1 AASGEDSTEEALAAAAAPWEGGPVPGVDR 29 0 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 AAS(0.648)GEDS(0.275)T(0.077)EEALAAAAAPWEGGPVPGVDR 134.17 1.5775e-14 0.0 154.46 291.01 239.35 224.6 163.14 166.4 216.57 173.24 148.74 0.0 True False 158.05861747315905 256.9384139131212 206.84758465543985 185.3778262641613 148.3840158047064 164.7261670791116 200.23395053849273 168.64511243717303 252.40091646021986 0.0 0.0 AAS(ph)GFNAMEDAQTLR ddPTM_A459_Selumetinib_30min_R1 2 AASGFNAMEDAQTLR 15 0 P09525;Q6P452;B4E1S2 P09525 ANXA4 Annexin A4;Annexin 1 AAS(1)GFNAMEDAQTLR;AAS(0.89)GFNAMEDAQT(0.11)LR 215.49 9.5318e-08 21554000.0 2327.17 2962.2 2581.3999999999996 2919.5 2943.2 2132.2599999999998 2780.8999999999996 2302.04 956.44 1684.89 True False 2381.388533115445 2615.384246910581 2230.8600586152165 2409.6641308023995 2676.988079664163 2110.811400337179 2571.134474084566 2240.9824211202354 1623.0088243862633 1901.1620437184076 1.2525962955045018 1.375676658153376 1.1734192074716396 1.2674690927920236 1.4080799101313572 1.1102743226499128 1.3524015391427582 1.1787435103307589 0.8536930503892686 1.0 10.892665788613664 -8.111450640930828 4.306317527537215 0.9320284842131711 1.274886049794146 0.6938747502087883 0.09154588422420654 0.12040268365051604 3.599865241562525 0.06372076622736704 0.02245531199134522 7.736586027530596e-09 8.111450640930828 0.342857565580975 AAS(ph)GFNAMEDAQTLR ddPTM_A459_Selumetinib_30min_R2 3 AASGFNAMEDAQTLR 15 0 P09525;Q6P452;B4E1S2 P09525 ANXA4 Annexin A4;Annexin 1 AAS(1)GFNAMEDAQTLR;AAS(1)GFNAMEDAQTLR;AAS(1)GFNAMEDAQTLR 166.36 8.0126e-05 13148800.0 22895.8 21666.0 26376.5 28894.800000000003 25768.699999999997 19433.4 18549.7 21412.0 22480.9 23136.699999999997 True False 21623.343095149343 23327.712532829795 24679.464706561805 24959.27839368976 22531.405530899123 22110.174451159073 19412.297805533224 21474.305375052583 26977.708168828336 22468.683354634057 0.9623769561330185 1.0382322882314583 1.0983938986114103 1.1108473958952307 1.002791537682698 0.9840440626708533 0.8639713106077278 0.9557438251326645 1.2006804200774104 1.0 14.455627965865489 -6.493930033130044 21.080543042507415 0.9899927193169147 1.0549886364003302 0.07012821657436819 0.08685685810222625 248.63180821128944 181053.5022554556 0.028170634427864875 0.03183242251439497 3.206785911083714e-07 6.493930033130044 0.06499591708341557 AAS(ph)GGSGSENVGPPAAAVPGPLSR ddPTM_A459_Selumetinib_30min_R1 1 AASGGSGSENVGPPAAAVPGPLSR 24 0 Q9UL54-2 Q9UL54-2 1 AAS(0.544)GGS(0.238)GS(0.218)ENVGPPAAAVPGPLSR 141.0 3.7516e-08 5044700.0 557.47 653.96 638.61 467.83 440.1 549.44 725.27 557.88 409.95 485.45 True False 570.4579663522076 577.3940591822441 551.8902696336344 386.13227275673444 400.2930327059658 543.913132451605 670.562299981773 543.0832101503703 695.6552084366482 547.7622361834312 1.0414335430038228 1.0540961407001594 1.0075361775192198 0.7049267862040581 0.7307788055909684 0.992973039253956 1.2241849760471972 0.9914579251288618 1.269994830756627 1.0 9.097405996984714 -7.006350769520793 24.81933689566176 1.118966387291614 0.9053312629223839 0.3529549709143892 0.13639029661494384 323.66978871905656 1264931.5086474188 0.052806752338913174 0.04498964966990434 9.854832123098857e-08 7.006350769520793 -0.21363512436923016 AAS(ph)GGSGSENVGPPAAAVPGPLSR ddPTM_A459_Selumetinib_30min_R2 1 AASGGSGSENVGPPAAAVPGPLSR 24 0 Q9UL54-2 Q9UL54-2 1 AAS(0.759)GGS(0.236)GS(0.004)ENVGPPAAAVPGPLSR 137.04 7.2324e-08 7264700.0 13400.0 9630.6 9036.4 15965.0 9233.4 5938.2 8844.1 11204.0 8276.1 8513.7 True False 12655.28164445013 10369.236052740265 8455.007862088409 13790.539458838854 8073.417744356678 6756.13314838745 9255.368174251684 11236.601785077944 9931.551253554808 8267.88735975087 1.5306548207293744 1.25415787631784 1.022632202665032 1.6679641193435892 0.976478922978451 0.8171535066233688 1.1194356879253091 1.359065659237105 1.2012199515323425 1.0 13.01330301853481 -1.5228796939988873 0.7207440452085007 1.1347864047456953 55.15579243997251 0.21596549708077506 0.22238554045354006 567.920021334424 2.770150198333294 0.0900776565570992 49606.54717612614 0.029999934464915876 1.5228796939988873 54.02100603522681 AAS(ph)KDTISNNR ddPTM_A459_Selumetinib_30min_R1 1 AASKDTISNNR 11 1 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 AAS(0.976)KDT(0.024)ISNNR 158.25 0.0027099 5106700.0 1361.0 1642.2 1767.3 1678.0 1172.5 1575.2 1302.2 1236.9 619.13 1205.2 True False 1392.7086519550005 1449.9304605619313 1527.3103670840137 1384.968799961099 1066.4475820216885 1559.3549181671667 1203.9740055927655 1204.0933939825634 1050.6183905339244 1359.899159642128 1.0241264156097476 1.0662043948490239 1.1231056040110663 1.0184349259584573 0.7842107809687414 1.1466695211264986 0.885340649750533 0.8854284418408152 0.7725708065077456 1.0 10.40928396019797 -6.38486217210604 0.7221250226549322 0.8868257446997408 1.0801602260528114 0.26691340932131136 0.10758787938937056 1.0038833826381326 1.1520426598343267 0.06893134086695409 0.10617290141369733 4.122283233080403e-07 6.38486217210604 0.19333448135307052 AAS(ph)LDSVATSR ddPTM_A459_Selumetinib_30min_R1 2 AASLDSVATSR 11 0 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4;Q9Y2J4-3 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 AAS(1)LDSVATSR;AAS(0.993)LDS(0.007)VATSR 196.02 2.0263e-05 23262000.0 2029.8 2085.1400000000003 2320.7 2765.7 2522.8 1750.59 2615.0 2434.4 1189.78 1525.37 True False 2077.0903906967374 1841.0108394447132 2005.5616866926234 2282.722413618838 2294.613185436515 1732.9806540085447 2417.748444651422 2369.8318039543647 2018.9697619069534 1721.1660978620253 1.2067925305273148 1.0696299687354724 1.1652342497239894 1.3262650341848814 1.3331735898625974 1.0068642742621965 1.4047153541164143 1.3768757163518908 1.17302436087653 1.0 10.749170613300532 -14.521410232273736 0.004378978176312974 0.7611756318360036 1.6417756734844284 0.004331920041278581 0.1420851114655222 1917572.2458757139 636.3315655128428 68359.24308199459 59866.912687834105 3.01016129837787e-15 14.521410232273736 0.8806000416484249 AAS(ph)LDSVATSR ddPTM_A459_Selumetinib_30min_R2 4 AASLDSVATSR 11 0 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4;Q9Y2J4-3 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 AAS(1)LDSVATSR;AAS(1)LDSVATSR;AAS(0.983)LDS(0.017)VATSR;AAS(1)LDSVATSR 148.78 0.00064275 28779800.0 186272.0 166029.0 240981.0 306583.0 311142.0 238894.0 217580.0 281028.0 222510.0 243638.0 True False 175919.74794589658 178762.89043262266 225476.54482027437 264825.8665148263 272053.56031522754 271799.4800361847 227697.9011265907 281845.74495331006 267018.217448857 236603.53789245384 0.7435212064574429 0.7555376898627688 0.952971992002769 1.1192810930629478 1.1498287926653372 1.1487549275773252 0.9623605088698585 1.191215260193703 1.1285470193189922 1.0 17.85211212064933 -5.4460276789983855 2.421497986598253 1.1066219741967303 0.7400425092541754 0.8131752176240317 0.06678694118967869 0.11607991233089791 1.3154079683768993 0.018789555338676236 0.04828539652355106 3.580736151804839e-06 5.4460276789983855 -0.3665794649425549 AAS(ph)LGSSQSSR ddPTM_A459_Selumetinib_30min_R2 1 AASLGSSQSSR 11 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;H0YA91;H0Y944;P20810-5;F8W7E0;E9PSG1;D6RGF7;D6RBR1;E7EN75 P20810-6;P20810-5 CAST Calpastatin 1 AAS(0.984)LGS(0.016)SQSSR 117.95 0.005450899999999999 5953800.0 13125.0 11400.0 11065.0 14435.0 14911.0 9346.2 7708.6 11709.0 9658.9 14219.0 True False 12395.56504353791 12274.343343222547 10353.089946661095 12468.928098236076 13037.746873968676 10633.554213643674 8067.065174301117 11743.071251470703 11590.94989221499 13808.460524601252 0.8976790005992256 0.8889002015361878 0.7497642425972074 0.9029919067387233 0.9441854036328331 0.7700752878786783 0.5842117707422037 0.8504258118093008 0.8394092789391309 1.0 13.753264865160936 -6.789028719349886 24.98539390348533 0.7854377171469913 0.8717899586602188 0.06951364630210932 0.10768899581804481 470.81773170298095 426377.50509578834 0.03830645239238146 0.033790313192859495 1.6254412638023874e-07 6.789028719349886 0.08635224151322751 AAS(ph)LNYLNQPSAAPLQVSR ddPTM_A459_Selumetinib_30min_R1 3 AASLNYLNQPSAAPLQVSR 19 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 AAS(0.609)LNYLNQPS(0.39)AAPLQVSR;AAS(1)LNYLNQPSAAPLQVSR;AAS(0.995)LNY(0.001)LNQPS(0.004)AAPLQVSR 276.05 1.1002e-59 118592400.0 2584.17 3359.15 3205.54 3010.8300000000004 3567.1600000000003 2719.2799999999997 3204.77 3103.97 1419.28 2699.9700000000003 True False 2644.3761330804973 2965.8591563735336 2770.2452747708335 2485.04506077883 3244.511007833249 2691.9265121086914 2963.0316187248704 3021.642632484482 2408.4144998901497 3046.537449434914 0.8679939692095329 0.9735180366562226 0.9093094441641187 0.8156949002021189 1.0649831363258169 0.8836019766006824 0.9725899214777312 0.9918284881234434 0.7905415705087997 1.0 11.572954759395108 -6.2318931431054505 24.996147109224914 0.9479328526960259 0.8987412114595439 0.11652803267304135 0.07835967676181656 1923.4051469446508 1627202.0416926872 0.02244268833494761 0.028968869575942986 5.862823998488098e-07 6.2318931431054505 -0.04919164123648201 AAS(ph)LNYLNQPSAAPLQVSR ddPTM_A459_Selumetinib_30min_R2 3 AASLNYLNQPSAAPLQVSR 19 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 AAS(0.993)LNY(0.007)LNQPSAAPLQVSR;AAS(0.999)LNYLNQPS(0.001)AAPLQVSR;AAS(1)LNYLNQPSAAPLQVSR 224.8 6.375900000000001e-20 129194000.0 59200.0 58453.6 78066.0 71029.0 72599.0 48874.8 49209.0 61777.0 51506.0 56340.4 True False 55909.90099637668 62936.80316205207 73043.31855183412 61354.727668140695 63478.46457670521 55606.86005873958 51497.31600578367 61956.76084226711 61808.63919788234 54713.706262060936 1.0218627984839184 1.1502931799320113 1.33500951666444 1.12137765579746 1.1601931017552334 1.016324132611319 0.9412141769217425 1.1323809896100676 1.1296737768382747 1.0 15.73961466557136 -6.7503739861466 23.284907196618 1.0457734097124538 1.1651605837053673 0.28640302457958056 0.08943199823884224 128.46064270968134 270318.12425033265 0.031331704633073235 0.031000098354317385 1.7767487306858065e-07 6.7503739861466 0.11938717399291354 AAS(ph)LSSIPSGIER ddPTM_A459_Selumetinib_30min_R2 1 AASLSSIPSGIER 13 0 A0A494C1D7;Q03001-13 A0A494C1D7 DST Dystonin 1 AAS(0.993)LS(0.005)S(0.002)IPSGIER 85.536 0.027675 2447300.0 16039.0 9646.3 12212.0 14689.0 10978.0 12184.0 14913.0 12794.0 11674.0 11569.0 True False 15147.61658920414 10386.14019225681 11426.293215420263 12688.332860061644 9598.845495434794 13862.235404660123 15606.484049548893 12831.228421839283 14009.126198813308 11234.97291012813 1.348255728818788 0.9244472839710977 1.0170289956925185 1.1293603430608485 0.854371930597323 1.2338468027958984 1.3890985028971385 1.1420791598235325 1.2469212263239484 1.0 13.455709025431673 AAS(ph)LTEDR ddPTM_A459_Selumetinib_30min_R2 2 AASLTEDR 8 0 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 AAS(0.954)LT(0.046)EDR;AAS(0.654)LT(0.346)EDR 109.44 0.01245 47043000.0 122456.0 82155.0 110508.0 123538.0 131925.0 94136.0 145149.0 165817.0 150947.0 86757.0 True False 115650.38575020793 88456.0243300394 103398.03559201326 106711.91128506332 115351.40207553605 107102.37951847397 151898.71610728698 166299.50001751803 181140.61781157003 84252.09998824328 1.3726706606285901 1.0498969680563779 1.2272457969171289 1.2665786526383809 1.369121981429928 1.271213174905068 1.8029071812866773 1.9738321067453966 2.1499834168744374 1.0 16.362425025545633 -7.259051433166104 5.904210019059827 1.8153599753136287 1.252185359955214 0.367864833029402 0.2952720788942582 0.14187718813241898 21.65871852243795 0.11371899142535014 0.08192920905095268 5.5074246853019445e-08 7.259051433166104 -0.5631746153584147 AAS(ph)LTEDRDR ddPTM_A459_Selumetinib_30min_R1 1 AASLTEDRDR 10 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 AAS(0.998)LT(0.002)EDRDR 156.01 0.0024486 5186400.0 3684.1 4112.4 5383.5 4918.5 4191.4 4275.4 4041.9 4593.9 2833.0 3341.9 True False 3769.9323619892884 3630.9182961971087 4652.45026944876 4059.5763066797767 3812.288610051773 4232.393357752606 3737.0162288476404 4472.054848909771 4807.394085866629 3770.8654178626193 0.9997525618737516 0.9628872669380933 1.2337884686655924 1.0765635621599041 1.0109850624721137 1.1223931084105323 0.9910234958652634 1.1859492061757526 1.2748781919115875 1.0 11.88067994629336 -7.781399155701838 24.78368974044649 1.1728103527460483 1.0614922280590458 0.16230452891996028 0.09753333081521841 359.09881059912556 445879.63686071837 0.05232816798989481 0.02519082863285974 1.6542488610274795e-08 7.781399155701838 -0.11131812468700253 AAS(ph)LTEDRDR ddPTM_A459_Selumetinib_30min_R2 1 AASLTEDRDR 10 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 AAS(0.913)LT(0.087)EDRDR 125.23 0.017381999999999998 1636200.0 18153.0 15959.0 22164.0 21972.0 22963.0 12104.0 17388.0 14452.0 16925.0 16664.0 True False 17144.128932216663 17183.003983727074 20737.992370338598 18979.37569618587 20078.18264817535 13771.216130827823 18196.57645366836 14494.052927342598 20310.472924011934 16182.86702172833 1.0593999758632182 1.061802210983745 1.2814782660262989 1.1728067511586628 1.2407061505984616 0.850975053575955 1.1244346523540156 0.8956418481275163 1.2550602372707858 1.0 13.98217960360978 -6.731276875973116 24.997346986585914 1.024900435022073 1.1647037205095179 0.23897610723639384 0.12313184399352944 299.25151013126043 248005.74120608295 0.03922695604151516 0.039222154328240964 1.8566204255778306e-07 6.731276875973116 0.13980328548744492 AAS(ph)PAKPSSLDLVPNLPK ddPTM_A459_Selumetinib_30min_R1 3 AASPAKPSSLDLVPNLPK 18 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 AAS(1)PAKPSSLDLVPNLPK;AAS(0.985)PAKPS(0.012)S(0.003)LDLVPNLPK;AAS(0.999)PAKPS(0.001)S(0.001)LDLVPNLPK 125.75 0.00044568 882250000.0 20050.9 27316.8 26044.5 27354.2 22343.7 20341.699999999997 21342.4 19391.6 12129.0 17479.3 True False 20518.046957740287 24118.5363567642 22507.799952198035 22577.302471928415 20322.716280100638 20137.08096678583 19732.525585135183 18877.27177520598 20582.027132889638 19722.938417800073 1.0403138986238798 1.2228672952199189 1.1411991192896798 1.1447230627436458 1.0304101675721535 1.0209980146067885 1.0004860922410252 0.9571226850340477 1.0435578460415529 1.0 14.267586886893131 -6.343717951582579 2.8395786120050337 1.0022744063930167 1.1455099162924274 0.6512573120859728 0.04615209917694055 0.1575506964145233 2.4814438225994984 0.014674163294232021 0.017398451161604347 4.5319180545661495e-07 6.343717951582579 0.1432355098994107 AAS(ph)PAKPSSLDLVPNLPK ddPTM_A459_Selumetinib_30min_R2 2 AASPAKPSSLDLVPNLPK 18 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 AAS(0.805)PAKPS(0.097)S(0.097)LDLVPNLPK;AAS(0.998)PAKPS(0.002)SLDLVPNLPK 98.376 0.0018078 560570000.0 770900.0 907910.0 834500.0 827860.0 884870.0 699930.0 779730.0 697750.0 556620.0 831990.0 True False 728056.4641572097 977543.7776092268 780809.1785349022 715104.0398618445 773704.7197618316 796339.0041680699 815988.9900056827 699780.3369812691 667959.5532622475 807968.286930376 0.9010953473473986 1.2098788942856904 0.9663859227709836 0.8850644900663858 0.9575929306597935 0.9856067583958179 1.009927002340375 0.8660987668709952 0.8267150630378723 1.0 19.62393914218348 -5.503939183034453 24.66975446281173 0.9332188718890256 1.0636484615210957 0.22584748508426677 0.08925038398967908 813.0519291330961 1059039.7654415942 0.022837815884918355 0.04631677780323436 3.1337245285853732e-06 5.503939183034453 0.13042958963207008 AAS(ph)PESASSTPESLQAR ddPTM_A459_Selumetinib_30min_R1 2 AASPESASSTPESLQAR 17 0 Q96BT3 Q96BT3 CENPT Centromere protein T 1 AAS(1)PESASSTPESLQAR;AAS(0.99)PES(0.01)ASSTPESLQAR 298.1 4.9801999999999984e-89 21240000.0 1911.9 2429.3 2120.9 1935.02 2103.66 2120.83 2018.54 1983.6 1118.5 1570.38 True False 1956.4435500902025 2144.87642664907 1832.8934292697822 1597.1050818240312 1913.3843244313387 2099.496375759569 1866.2799026641217 1930.9884843591353 1898.0128079921724 1771.9535697965528 1.1041167124457059 1.2104585939547696 1.034391341010265 0.9013244528790917 1.0798162869758627 1.1848484133817476 1.053232959641487 1.0897511747900044 1.0711413889981853 1.0 10.791125086353073 -7.934518247713506 0.008599679453508419 2.332048947301999e-07 2.128180137789478 0.07732851323600154 0.08001307462964502 4634.171407354273 40.87353194446999 5053.785371055614 5055.218309686306 1.1627376953282758e-08 7.934518247713506 2.128179904584583 AAS(ph)PESASSTPESLQAR ddPTM_A459_Selumetinib_30min_R2 2 AASPESASSTPESLQAR 17 0 Q96BT3 Q96BT3 CENPT Centromere protein T 1 AAS(1)PESASSTPESLQAR;AAS(0.982)PES(0.013)AS(0.002)S(0.002)T(0.002)PESLQAR 189.04 7.006300000000001e-08 30940000.0 44931.8 35752.0 43323.0 47249.0 44813.0 38504.4 33366.3 40793.1 33736.4 42973.2 True False 42434.67043224658 38494.063439201105 40535.645346515885 40813.60469092877 39183.19030669694 43808.03159185781 34917.89906406913 40911.80116733873 40484.62267377468 41732.45205821749 1.0168266741922924 0.922401189978035 0.9713219172927573 0.9779824256191102 0.9389141632999594 1.0497353841261197 0.8367085407624278 0.9803354260196852 0.9700993034700652 1.0 15.348882070538977 -4.733420897884772 23.57237642964015 0.959296660309168 1.0168273016673806 0.09183741178227478 0.05262469686139981 3532.678188212265 2971769.6167475996 0.012421492824653475 1.0248729991758647 1.847477262576911e-05 4.733420897884772 0.05753064135821251 AAS(ph)PFR ddPTM_A459_Selumetinib_30min_R1 4 AASPFR 6 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 AAS(1)PFR;AAS(1)PFR;AAS(1)PFR;AAS(1)PFR 122.74 0.0175 1106780000.0 8333.3 9439.1 10612.8 10429.4 9848.3 8101.1 8288.4 8737.0 4918.7 6991.1 True False 8527.449676220875 8333.965783881464 9171.640051937542 8608.101074084796 8957.523003858583 8019.610289210287 7663.199314970872 8505.266378224314 8346.674652365755 7888.475784080722 1.0810009321990477 1.0564735206134193 1.162663143423258 1.0912248842110042 1.1355201244244475 1.016623554247856 0.9714423324256801 1.0781888175898697 1.0580845883066152 1.0 12.945530853446032 -6.770792012605 24.999622377051516 1.0264155504417047 1.105056076696702 0.5211738741026233 0.038569383205996136 176.84323074394172 472699.4422519915 0.014034653931923899 0.012538125336174984 1.69514942785097e-07 6.770792012605 0.07864052625499718 AAS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 5 AASPFR 6 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 AAS(1)PFR;AAS(1)PFR;AAS(1)PFR;AAS(1)PFR;AAS(1)PFR 125.81 0.014951 1398665000.0 3953475.0 3081026.0 3601209.0 4174547.0 3991045.0 3064127.0 2924747.0 2799094.0 2485146.0 3065975.0 True False 3733756.6865143604 3317330.7871399717 3369511.133639893 3605966.4971047523 3489654.246705005 3486182.680874505 3060753.5307762325 2807238.90012504 2982244.640780882 2977452.3353902684 1.2540105653865856 1.1141507616124957 1.1316759276343666 1.2110912588738727 1.1720269054273877 1.1708609536540424 1.0279773396859586 0.9428325238855864 1.001609532194236 1.0 21.50564698218384 -7.3463288626749925 3.3597943439452655 0.9797168360990164 1.173256733137854 0.8381169915571021 0.03962126289735345 0.0959198434648395 2.0826249234497958 0.017885104855417666 0.011600657019517293 4.504754598902701e-08 7.3463288626749925 0.19353989703883767 AAS(ph)PHQVTPQADEK ddPTM_A459_Selumetinib_30min_R1 3 AASPHQVTPQADEK 14 0 Q96L73-2;Q96L73-3;Q96L73 Q96L73-2 NSD1 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 1 AAS(1)PHQVTPQADEK;AAS(1)PHQVTPQADEK;AAS(1)PHQVTPQADEK 180.56 7.3881e-05 18619500.0 7632.700000000001 8778.4 6510.139999999999 7476.200000000001 7157.6 7033.099999999999 7304.1 6924.3 3824.2 7316.700000000001 True False 7810.527059351171 7750.620847032559 5626.098745639291 6170.622015655044 6510.19634377692 6962.353399543867 6753.145856435352 6740.645070703748 6489.388091482942 8255.8697156933 0.9460574510404892 0.9388012546152067 0.6814665128429575 0.7474224071057615 0.7885536676289733 0.8433216171409983 0.8179811563157942 0.8164669868627756 0.7860332484592735 1.0 13.01120448870738 -9.598255773466647 11.073886607075833 0.9999999997989453 0.815656662035558 0.340891571142087 0.07564085848241811 0.0 0.0 0.07849856439380691 0.019038698379706797 2.5219950308311055e-10 9.598255773466647 -0.1843433377633873 AAS(ph)PHQVTPQADEK ddPTM_A459_Selumetinib_30min_R2 2 AASPHQVTPQADEK 14 0 Q96L73-2;Q96L73-3;Q96L73 Q96L73-2 NSD1 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 1 AAS(1)PHQVTPQADEK;AAS(1)PHQVTPQADEK 144.15 0.000352 49223000.0 142446.0 123938.0 143933.0 151679.0 151169.0 122760.0 129343.0 140887.0 124760.0 132800.0 True False 134529.42157651822 133443.64607651872 134672.50748240144 131020.05853913058 132177.79875199328 139669.07569567274 135357.70578829214 141296.9578449016 149715.4860856563 128965.71894416238 1.0431409422434557 1.034721840571409 1.0442504301527595 1.0159293462773442 1.0249064622298707 1.0829938129228323 1.049563456835357 1.0956164087766471 1.1608936646992047 1.0 16.97662810069078 -7.076681457645999 1.5178146467903115 1.0894927488259634 1.0328969556280883 0.21315299549239008 0.03947145836784762 0.5377674831763919 2.4788417373231293 0.020091007927020076 0.014009078829913379 8.381438108048539e-08 7.076681457645999 -0.05659579319787511 AAS(ph)PPASASDLIEQQQK ddPTM_A459_Selumetinib_30min_R1 4 AASPPASASDLIEQQQK 17 0 Q5VSL9;Q5VSL9-3;Q5VSL9-2 Q5VSL9 STRIP1 Striatin-interacting protein 1 1 AAS(1)PPASASDLIEQQQK;AAS(1)PPASASDLIEQQQK;AAS(1)PPASASDLIEQQQK;AAS(1)PPASASDLIEQQQK 278.89 1.2919e-63 144899700.0 9377.3 11438.3 11059.7 13050.3 11115.400000000001 9809.6 10962.0 10122.9 6044.5 8946.08 True False 9595.772844950496 10099.098518478591 9557.853486583537 10771.310089470988 10110.014032583264 9710.924330404163 10135.127514443167 9854.407808186665 10257.075027187027 10094.396510198514 0.9506039152767328 1.0004658038026668 0.9468474392626741 1.0670583505005553 1.0015471477040723 0.9620113813235963 1.0040350113256897 0.9762255522884022 1.0161157248800516 1.0 13.301267041801886 -3.4100156784453017 1.1852313958335798 0.9978952805365113 1.5978899049805886e-11 0.16570718407253204 0.030954719777059124 67.34372522976412 5.393184622274415 0.009152778047366833 162.60186018401023 0.0003890311003467429 3.4100156784453017 -0.9978952805205324 AAS(ph)PPASASDLIEQQQK ddPTM_A459_Selumetinib_30min_R2 3 AASPPASASDLIEQQQK 17 0 Q5VSL9;Q5VSL9-3;Q5VSL9-2 Q5VSL9 STRIP1 Striatin-interacting protein 1 1 AAS(0.999)PPAS(0.001)ASDLIEQQQK;AAS(1)PPASASDLIEQQQK;AAS(1)PPASASDLIEQQQK 190.24 7.449399999999999e-08 173058000.0 95049.0 82614.0 98743.0 98723.0 104478.0 80153.0 81826.0 78567.0 66403.0 93703.0 True False 89766.55709129399 88950.22815412178 92389.98288324944 85276.75709332584 91352.53959482918 91193.34819350977 85631.07113514299 78795.61696253301 79685.45545483989 90997.55092036774 0.9864722312125631 0.9775013421181239 1.0153018619600018 0.9371324418165036 1.0039010794342378 1.0021516762941607 0.9410261075056737 0.8659092048695609 0.8756879130139766 1.0 16.473540097140052 -7.495479541424955 4.843209747165324 0.9026104124437386 0.9858160007459029 0.40856767413764916 0.039372917818680415 0.16193746483365346 9.846149352366924 0.017085807036026728 0.010637711578618028 3.195364887265485e-08 7.495479541424955 0.08320558830216429 AAS(ph)PPRPLLSNASATPVGR ddPTM_A459_Selumetinib_30min_R1 3 AASPPRPLLSNASATPVGR 19 1 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 AAS(0.862)PPRPLLS(0.01)NAS(0.121)AT(0.007)PVGR;AAS(0.776)PPRPLLS(0.067)NAS(0.103)AT(0.054)PVGR;AAS(0.994)PPRPLLS(0.005)NASAT(0.001)PVGR 110.56 0.0030871 110319300.0 3217.54 3772.03 3394.29 3977.25 3404.25 2899.88 3424.58 2451.6 1666.51 2442.11 True False 3292.5024217570144 3330.398974030826 2933.364061500368 3282.6979497290085 3096.3361885691534 2870.709840080373 3166.2611734548236 2386.575604080889 2827.9457529253777 2755.5786066658125 1.1948497545279129 1.2086024205495387 1.0645183753439251 1.1912917097658116 1.1236609912266846 1.0417811464844644 1.149036781529498 0.8660887402405085 1.0262620511294824 1.0 11.428139567277764 -7.202419918474321 0.9314753102963068 0.9666507345556904 1.1653051315507055 0.5261401449842547 0.07056986361941701 0.439816173991706 0.7527591335904368 0.05082935660682109 0.030768669445049916 6.274513839189105e-08 7.202419918474321 0.19865439699501508 AAS(ph)PPRPLLSNASATPVGR ddPTM_A459_Selumetinib_30min_R2 1 AASPPRPLLSNASATPVGR 19 1 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 AAS(0.952)PPRPLLS(0.016)NAS(0.028)AT(0.004)PVGR 53.718 0.035187 231480000.0 21373.0 20747.0 19761.0 21113.0 34700.0 20741.0 16012.0 20744.0 18935.0 21436.0 True False 20185.174222897946 22338.22818788055 18489.59877415002 18237.372978043517 30340.675778064062 23597.884481948087 16756.589727176088 20804.361605645918 22722.52908810433 20817.086982583336 0.9696445155744374 1.0730717610283265 0.8881933764132987 0.876077089618824 1.4574890234857865 1.1335824508823598 0.8049440222445882 0.99938870520414 1.0915326004601502 1.0 14.345480580280427 -1.5829310662237037 19.784375857585484 1.030959781142131 0.006733387449832096 0.0 0.1729363792287656 0.0 0.0 0.041446875564808236 0.0 0.026125760049308 1.5829310662237037 -1.0242263936922988 AAS(ph)PQDLAGGYTSSLACHR ddPTM_A459_Selumetinib_30min_R1 2 AASPQDLAGGYTSSLACHR 19 0 P51948;P51948-2;H0YJ92 P51948 MNAT1 CDK-activating kinase assembly factor MAT1 1 AAS(1)PQDLAGGYTSSLACHR;AAS(1)PQDLAGGYTSSLACHR 199.36 5.2537e-22 10629000.0 1626.5 2075.15 2480.79 2164.38 2365.65 1970.99 1684.87 1861.95 1201.03 1976.29 True False 1664.3942853819317 1832.1904732889375 2143.912344004048 1786.4116634444595 2151.67737518943 1951.1636301157348 1557.7788994033801 1812.565037534024 2038.0601902394626 2229.966072194774 0.7463765059635208 0.8216225780895678 0.9614102971055384 0.8010936514770559 0.9648924268483194 0.8749745812030958 0.6985661884398919 0.8128218003559416 0.9139422413873616 1.0 11.122806045099729 -8.533423195774319 3.853819304685989 0.9996487758062217 0.8394401866499788 0.3016056635022616 0.07935117615152315 0.2598770446730124 11.51910179230177 0.07964427090838913 0.02091062054911871 2.9280386441389433e-09 8.533423195774319 -0.16020858915624292 AAS(ph)PQDLAGGYTSSLACHR ddPTM_A459_Selumetinib_30min_R2 1 AASPQDLAGGYTSSLACHR 19 0 P51948;P51948-2;H0YJ92 P51948 MNAT1 CDK-activating kinase assembly factor MAT1 1 AAS(1)PQDLAGGYTSSLACHR 192.16 2.0077000000000007e-15 11581000.0 47692.0 32331.0 35170.0 52422.0 48683.0 38254.0 36611.0 37413.0 45283.0 46181.0 True False 45041.46956620263 34810.68373944984 32907.2004902007 45282.03316700598 42567.00630845799 43523.14126476265 38313.48404332021 37521.865635944414 54340.86531273458 44847.63453735216 1.0043220792099754 0.7761988809121502 0.7337555442928289 1.0096860990358816 0.9491471902047652 0.9704668197943331 0.8543033414930755 0.836652055855781 1.2116774022379222 1.0 15.452744272581862 -8.252749198218568 24.839421001988622 1.1058387070660054 0.8899051269885757 0.4197847667269856 0.10062673116829399 500.6688118019558 1431088.2701828189 0.07184615466480554 0.026200503144387665 5.587928001961972e-09 8.252749198218568 -0.2159335800774297 AAS(ph)PSPQSVR ddPTM_A459_Selumetinib_30min_R1 4 AASPSPQSVR 10 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 AAS(0.687)PS(0.313)PQSVR;AAS(0.871)PS(0.129)PQSVR;AAS(0.981)PS(0.019)PQSVR;AAS(0.978)PS(0.022)PQSVR 150.09 0.00072349 616880000.0 20781.5 23156.1 20458.6 22293.6 22806.8 17589.1 21344.1 19810.7 10832.0 16655.8 True False 21265.668516240163 20444.97304702117 17680.434491045668 18400.44126270127 20743.928966867592 17412.169623625003 19734.097352766497 19285.255881777317 18381.11286202165 18793.734171230808 1.1315297067888381 1.0878611382254229 0.9407621886080859 0.9790731897691953 1.1037683505506912 0.9264880233476599 1.0500359946016042 1.0261534885014456 0.978044740579507 1.0 14.197964127258794 -5.065533447803668 5.759022734728129 1.0036741779359253 1.1220581831795882 0.45229200045413565 0.04898103033467281 0.16636782370415107 10.709053014347278 0.012216755508525048 0.03488513239816293 8.599368350870127e-06 5.065533447803668 0.11838400524366288 AAS(ph)PSPQSVR ddPTM_A459_Selumetinib_30min_R2 3 AASPSPQSVR 10 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 AAS(0.633)PS(0.364)PQS(0.003)VR;AAS(0.899)PS(0.101)PQSVR;AAS(0.905)PS(0.095)PQSVR 122.55 0.0044309 436788000.0 203757.0 205355.0 209479.0 224888.0 223219.0 153674.0 171021.0 162691.0 159702.0 193043.0 True False 192433.00164389733 221105.06817960236 196001.34920348995 194257.86644656162 195176.23361682091 174841.1985863213 178973.81537168243 163164.40387505502 191646.8624467093 187469.34700405068 1.026477153300904 1.1794198449671076 1.0455114520629067 1.0362113569551414 1.04111011605862 0.9326388627285477 0.954683089432297 0.8703524415195701 1.0222837253632102 1.0 17.516295195162776 -6.326915800714877 1.2385620676101206 0.9470813718525338 1.0946037562519386 0.4879691617743108 0.055740501104185894 0.34124021399039955 1.0749638315909584 0.02225480697443554 0.030201392784890146 4.7106864645802206e-07 6.326915800714877 0.1475223843994048 AAS(ph)PVLLSSNSQK ddPTM_A459_Selumetinib_30min_R1 2 AASPVLLSSNSQK 13 0 G3V1Z7;P41970 G3V1Z7 ELK3 ETS domain-containing protein Elk-3 1 AAS(0.999)PVLLS(0.001)SNSQK;AAS(1)PVLLSSNSQK 182.02 0.0001166 19408600.0 4495.7 5354.5 6136.0 6998.9 6032.4 4892.6 5078.3 4687.4 2946.0699999999997 4073.7 True False 4600.4410628905935 4727.592650760482 5302.764902635383 5776.673500624392 5486.770485106723 4843.384886125371 4695.239742437215 4563.074925178971 4999.265617560574 4596.5990761982575 1.0008358324553974 1.0284979334483455 1.1536278919981813 1.2567277251863669 1.1936587016078648 1.0536887829101738 1.0214594887663209 0.9927067489542696 1.0876009707801955 1.0 12.166351121796826 -6.939884535742261 7.384919269508789 1.0265637938389598 1.1297950978593891 0.30532917200592 0.07298263825333838 0.32210749811572503 33.19767964099147 0.02935190154227734 0.02583408761965666 1.1484589174096859e-07 6.939884535742261 0.10323130402042935 AAS(ph)PVLLSSNSQK ddPTM_A459_Selumetinib_30min_R2 4 AASPVLLSSNSQK 13 0 G3V1Z7;P41970 G3V1Z7 ELK3 ETS domain-containing protein Elk-3 1 AAS(1)PVLLSSNSQK;AAS(1)PVLLSSNSQK;AAS(1)PVLLSSNSQK;AAS(0.993)PVLLS(0.003)S(0.003)NSQK 182.02 0.0001166 55696000.0 140271.0 106255.0 134819.0 149546.0 134383.0 98964.0 104091.0 110930.0 93572.2 110810.0 True False 132475.29936930336 114404.41683632568 126144.8923198282 129177.57681876051 117500.60614073725 112595.3926942534 108931.43775240361 111252.78793454976 112289.25462571494 107610.6273810437 1.2310614907969557 1.0631330717107106 1.1722345217183394 1.2004165384274674 1.0919052234931559 1.0463222400475272 1.0122739770551006 1.033845732918268 1.0434773716921513 1.0 16.715461036651277 -6.588382646352414 2.757354285833313 1.0271337916760044 1.1594213149621673 0.7026807096298145 0.0425667024266083 0.1585987346959179 2.4483624717185313 0.014813743108785376 0.015187546045426796 2.579986025707947e-07 6.588382646352414 0.1322875232861629 AAS(ph)QVLNSMWQYR ddPTM_A459_Selumetinib_30min_R1 1 AASQVLNSMWQYR 13 0 D6R9A8;B4DRK2;E9PHB5;E7EPC8;Q9UQB3-2;Q9UQB3 D6R9A8 CTNND2 Catenin delta-2 1 AAS(1)QVLNSMWQYR 98.048 0.016069999999999997 0.0 272.1 480.18 487.14 488.78 519.5 423.87 277.15 369.45 288.98 299.89 True False 278.4394005855665 423.9603023703744 420.98906366848144 403.42374853694014 472.5113167251744 419.60625264316707 256.24435236525477 359.6509858572709 490.3779537358767 338.3838026759691 0.8228508527407135 1.2528977422017802 1.2441170657084133 1.1922076214837394 1.396376874390893 1.240030549112823 0.757259509287536 1.0628492942425702 1.449176792322577 1.0 8.402516702800211 AAS(ph)SSS(ph)PGSPVASSPSR ddPTM_A459_Selumetinib_30min_R1 1 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 2 AAS(0.444)S(0.141)S(0.421)S(0.714)PGS(0.265)PVAS(0.012)S(0.003)PSR 127.2 0.020212 4352000.0 929.41 798.08 838.42 1110.8 1021.5 752.26 696.95 705.03 540.73 717.96 True False 951.0634446829514 704.6404225826739 724.5671691114012 916.8196322984429 929.1055053604733 744.6929473974309 644.3785003823358 686.3303141398068 917.5793166433684 810.1171595226208 1.1739825943736166 0.8698006384630818 0.8943980023066889 1.131712396807764 1.1468779477624804 0.9192410488333038 0.7954139630396793 0.8471988354675043 1.1326501430781593 1.0 9.661986756092256 -6.88671092518256 23.033825514073413 0.9203498568914142 1.0306308973996918 0.1331627688785546 0.12691880779155273 9.483979403172725 1881.1108926801967 0.04672624399492762 0.04120870294044347 1.2980429860479628e-07 6.88671092518256 0.11028104050827758 AAS(ph)YTEEDENHTAK ddPTM_A459_Selumetinib_30min_R1 3 AASYTEEDENHTAK 14 0 Q14126 Q14126 DSG2 Desmoglein-2 1 AAS(0.977)YT(0.023)EEDENHTAK;AAS(0.991)YT(0.009)EEDENHTAK;AAS(0.999)YT(0.001)EEDENHTAK 119.04 0.0015016 38735600.0 12978.3 11244.400000000001 14599.9 9616.7 12507.7 11519.3 11316.0 14472.6 6384.5 10862.8 True False 13280.669138624242 9927.900420620259 12617.313771510162 7937.323872816383 11376.38074341379 11403.426300687566 10462.425009436127 14088.739634369833 10834.030194569543 12257.146192632357 1.083504180329277 0.8099683453712755 1.0293842933108115 0.6475670395109937 0.9281426985224354 0.9303492119186803 0.8535775656918395 1.1494306597108572 0.8838949967882218 1.0 13.581335497811708 -7.721521946056239 24.999792595316606 1.0124981190531444 0.8920342591870091 0.14256847716931997 0.12716963516090013 263.8092140142959 165220.22273889746 0.05679011524444138 0.03278722523043129 1.8987948885167834e-08 7.721521946056239 -0.12046385986613528 AAS(ph)YTEEDENHTAK ddPTM_A459_Selumetinib_30min_R2 2 AASYTEEDENHTAK 14 0 Q14126 Q14126 DSG2 Desmoglein-2 1 AAS(0.999)YT(0.001)EEDENHTAK;AAS(0.999)YT(0.001)EEDENHTAK 174.59 8.3015e-05 13085500.0 115502.0 62726.0 99887.0 102768.0 81421.0 62729.3 127935.0 86196.0 79582.0 70009.0 True False 109082.86123114022 67536.88250412076 93460.37916874267 88770.82111531188 71192.16606702452 71369.69167511043 133884.2309983931 86446.81608948403 95500.62370686662 67987.65826477318 1.6044509255830617 0.9933697413301557 1.3746668373952189 1.3056902293884003 1.0471336693164457 1.049744813936173 1.9692431599422104 1.2715074808551714 1.4046758800684989 1.0 16.052985258615294 AASAPAKES(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 AASAPAKESPR 11 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR 126.5 0.0017305999999999995 4296249000.0 40679.299999999996 48975.5 49312.4 54346.5 50502.5 47954.600000000006 47981.7 46344.6 30133.7 40781.899999999994 True False 41627.04854186121 43241.42569190773 42616.04693362401 44855.90398515249 45934.55779194053 47472.220263293035 44362.401738711706 45115.39065952325 51134.68802163051 46016.65411434559 0.9046083280723374 0.9396907820472613 0.9261005119522272 0.9747754339915982 0.9982159432495666 1.0316312903874008 0.9640510070218649 0.9804144070843827 1.111221339443047 1.0 15.48986846810653 -5.664748926321357 0.5563500020432609 1.0248057325304516 0.8831346138735257 0.545099535765492 0.03756346269133745 1.4292258487778817 0.6545051294283907 0.02518233932721276 0.1175156290891505 2.163969192819472e-06 5.664748926321357 -0.14167111865692594 AASAPAKES(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 AASAPAKESPR 11 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR;AASAPAKES(1)PR 85.67200000000003 0.018997 3644390000.0 417100.0 390603.0 375105.0 445500.0 459955.0 324808.0 360211.0 400889.0 333225.0 433434.0 True False 393919.2517835931 420560.99411339907 350971.1526834445 384822.131469635 402171.3408501284 369547.3536865434 376961.52524455567 402055.52061925305 399879.3110844249 420919.6342232227 0.935853829937259 0.9991479606065765 0.8338198652365952 0.9142413424828636 0.9554587340462439 0.8779522826691534 0.8955665039009439 0.9551835740834898 0.9500134433556985 1.0 18.683185281658695 -8.440112332536952 1.433483323240044 0.9975211589564648 0.917062240901098 0.2567983025833811 0.04289931730901114 0.5794407043225903 2.572315120750841 0.0414897160255202 0.012480209193032391 3.6298415487850876e-09 8.440112332536952 -0.08045891805536676 AASAPAKGT(ph)PGKGATPAPPGK ddPTM_A459_Selumetinib_30min_R2 1 AASAPAKGTPGKGATPAPPGK 21 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AAS(0.199)APAKGT(0.64)PGKGAT(0.161)PAPPGK 60.764 0.024884 20111000.0 119690.0 154850.0 141410.0 160850.0 151580.0 110380.0 74947.0 77952.0 59097.0 169540.0 True False 113038.10895703264 166726.4970787727 132311.8345555667 138941.95251827326 132537.16525760648 125583.84307012359 78432.18400466311 78178.8274143517 70918.05130814371 164644.93968217817 0.6865568366403206 1.0126427049662907 0.8036191990532744 0.843888386648745 0.8049877847047663 0.7627555594028214 0.47637166472327924 0.4748328589099911 0.43073325815564173 1.0 17.328998646208426 -7.099760231988354 3.967779943861275 0.5528894760243566 0.8363494543961066 0.2895111464420014 0.16831897774898802 0.2427467245176816 6.786374312287691 0.06301474602209685 0.048605241836481676 7.947668934977744e-08 7.099760231988354 0.2834599783717501 AASDGQYENQS(ph)PEATSPR ddPTM_A459_Selumetinib_30min_R1 1 AASDGQYENQSPEATSPR 18 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 AASDGQYENQS(0.999)PEATSPR 177.12 2.1007e-09 5407400.0 682.64 546.05 412.36 751.61 1242.3 441.54 1003.5 879.16 220.65 309.7 True False 698.5441838137853 482.11821214824204 356.36377693134415 620.3554229670809 1129.9341843458787 437.09850848624365 927.8051870775148 855.8418208858518 374.42693436162085 349.4530117334609 1.9989645542004584 1.3796367350125147 1.019775949743865 1.7752184188935993 3.233436675050653 1.2508076731633173 2.6550212930635197 2.4490898408356827 1.07146575301863 1.0 8.44895467027817 -3.0782905590223986 15.019046073207296 1.840645480086019 7.26067651974225 0.0 0.7439900678302681 0.0 0.0 0.17010880935077827 0.0 0.0008350441559709273 3.0782905590223986 5.420031039656231 AASDGQYENQS(ph)PEATSPR ddPTM_A459_Selumetinib_30min_R2 2 AASDGQYENQSPEATSPR 18 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 AASDGQYENQS(0.998)PEAT(0.002)SPR;AASDGQYENQS(1)PEATSPR 204.51 5.4498e-11 18231500.0 35974.0 28153.0 35117.0 35815.0 40757.0 17931.6 22150.3 26654.1 18154.5 19046.5 True False 33974.709095332 30312.244573837223 32857.61045249864 30936.935215678917 35636.74128779702 20401.51513314212 23180.332839986786 26731.659018176222 21785.907279112223 18496.57805624993 1.8368105166269963 1.6388028359437445 1.776415634966391 1.6725761447115581 1.9266667152930748 1.1029886215222666 1.2532227728552325 1.4452218641135994 1.1778344736447528 1.0 14.17497077040366 -6.764361563740951 24.999991125870764 1.227265444642818 1.7578672510672917 0.8246011981715212 0.13199890085939556 32.714723099857835 279879.9431491175 0.04468768693610543 0.04112706520984167 1.7204356620923097e-07 6.764361563740951 0.5306018064244737 AASDPLLS(ph)SVSPAVSK ddPTM_A459_Selumetinib_30min_R2 1 AASDPLLSSVSPAVSK 16 0 P19532 P19532 TFE3 Transcription factor E3 1 AASDPLLS(0.614)S(0.347)VS(0.039)PAVSK 241.66 1.4177e-21 72274000.0 47620.0 45266.0 45843.0 48544.0 53817.0 32813.0 45097.0 44844.0 34048.0 38355.0 True False 44973.47103796379 48737.75664686945 42893.51129008446 41932.223456929125 47056.027329915676 37332.69290324299 47194.099858010224 44974.48861567616 40858.55138060608 37247.59149174208 1.2074195736369844 1.308480755263727 1.151578117462819 1.125770063984557 1.2633307401996223 1.002284749378219 1.2670376249286701 1.207446892925873 1.0969447887567323 1.0 15.1848595204193 -14.522878744449121 0.12381616351726303 0.40281174999822633 1.2657517578357338 0.34074362176043616 0.0829145852549949 181.47823450426182 1.4366441563670993 27.050985282350183 0.7270485839165368 3.000000005741838e-15 14.522878744449121 0.8629400078375075 AASDPLLSS(ph)VSPAVSK ddPTM_A459_Selumetinib_30min_R1 2 AASDPLLSSVSPAVSK 16 0 P19532 P19532 TFE3 Transcription factor E3 1 AASDPLLS(0.147)S(0.85)VS(0.004)PAVSK;AASDPLLS(0.03)S(0.829)VS(0.14)PAVSK 216.0 1.4662e-10 103982000.0 20510.3 21050.4 25173.0 24893.0 23449.0 20328.7 22117.4 20941.9 12151.400000000001 17530.0 True False 20988.150083903496 18585.809381934534 21754.644865391216 20545.904849482482 21328.042090257197 20124.21173498278 20449.0667111791 20386.45278312187 20620.038296858384 19780.146256659897 1.0610715316039117 0.9396194113416511 1.0998222451498059 1.0387134949805923 1.0782550246854787 1.0173944860598307 1.0338177709021732 1.030652277217507 1.0424613665288596 1.0 14.27176547313777 -5.265106507799227 24.996354238830037 1.0436493923758257 1.000345475577742 0.163378108368342 0.038228524378628684 463.2027524218036 3157379.496008252 0.009298428965899925 0.02068027698378409 5.431171193396413e-06 5.265106507799227 -0.043303916798083764 AASDPLLSS(ph)VSPAVSK ddPTM_A459_Selumetinib_30min_R2 2 AASDPLLSSVSPAVSK 16 0 P19532 P19532 TFE3 Transcription factor E3 1 AASDPLLS(0.049)S(0.795)VS(0.156)PAVS(0.001)K;AASDPLLS(0.11)S(0.723)VS(0.166)PAVSK 147.75 0.0003082 24008000.0 80071.0 76997.0 100057.0 96748.0 104425.0 64888.9 83284.0 85313.0 70414.0 92438.0 True False 75620.97436960942 82902.42231562323 93619.44155382444 83570.75550039094 91306.19792865527 73826.75697221346 87156.8710241153 85561.2467056726 84498.76753154384 89769.07475723245 0.8423944946978174 0.9235075947905323 1.0428919068956068 0.9309526217842394 1.0171230813682746 0.8224074623902197 0.9709008504300454 0.953126084200608 0.9412903915970907 1.0 16.453930904933472 -11.208818654092086 0.007251946796237166 1.9608845098103906 1.1175319625583993e-07 0.08824751212967674 0.06389227279856331 41920.65922553308 46.02294674712794 6568.174308948594 5889.37608453492 6.18274515662163e-12 11.208818654092086 -1.9608843980571944 AASDPLLSSVS(ph)PAVSK ddPTM_A459_Selumetinib_30min_R1 2 AASDPLLSSVSPAVSK 16 0 P19532 P19532 TFE3 Transcription factor E3 1 AASDPLLS(0.285)S(0.046)VS(0.668)PAVSK;AASDPLLS(0.114)S(0.383)VS(0.503)PAVSK 210.91 4.2047e-08 88340000.0 11863.0 12299.099999999999 13911.0 14208.3 12722.8 11350.4 11864.1 11690.1 6992.7 9673.2 True False 12139.384818620256 10859.115654303529 12021.96260765332 11727.087127823172 11572.02498639278 11236.225281338631 10969.181385158288 11380.04057320363 11866.101173399078 10914.849444947093 1.1121898547340978 0.9948937645979747 1.1014318308548685 1.0744158393547145 1.0602093088649902 1.029443909236908 1.0049778002422514 1.042620022438504 1.0871520705118252 1.0 13.414004610058985 -6.670702121233102 4.746429494983996 1.0338066644962396 1.067407779103273 0.19424983448101363 0.03660416024941692 0.4073646864593447 15.898950030896426 0.012200436206537588 0.012069713138447482 2.1345084517559095e-07 6.670702121233102 0.03360111460703341 AASDPLLSSVS(ph)PAVSK ddPTM_A459_Selumetinib_30min_R2 3 AASDPLLSSVSPAVSK 16 0 P19532 P19532 TFE3 Transcription factor E3 1 AASDPLLS(0.003)S(0.043)VS(0.948)PAVS(0.006)K;AASDPLLS(0.001)S(0.016)VS(0.983)PAVS(0.001)K;AASDPLLS(0.025)S(0.395)VS(0.578)PAVS(0.002)K 149.19 0.00026633 95218000.0 151056.0 136148.0 158549.0 168075.0 180485.0 113147.0 131588.0 144947.0 121062.0 151223.0 True False 142660.91224507883 146590.11381518107 148348.12995509867 145182.89505445288 157810.86074362815 128731.97220379833 137707.10273667527 145368.7717727324 145277.78275490287 146856.79906546025 0.9714287193573439 0.9981840456010463 1.0101550006477649 0.9886017942535896 1.074590088765895 0.8765816293355072 0.937696474477109 0.989867494714599 0.9892479182400432 1.0 17.16405053445405 -6.752574497638286 24.99999905889057 0.9567340269463378 1.0069899664159518 0.2662852768057924 0.04132050632240103 279.3425849060302 787777.8740501279 0.014068858273327071 0.013873196092289656 1.7677689536739235e-07 6.752574497638286 0.05025593946961404 AASDS(ph)NPAGPLR ddPTM_A459_Selumetinib_30min_R1 1 AASDSNPAGPLR 12 0 Q9BUU2-2;Q9BUU2 Q9BUU2-2 METTL22 Methyltransferase-like protein 22 1 AAS(0.141)DS(0.859)NPAGPLR 149.57 0.0017772000000000005 0.0 1377.0 1376.4 1660.9 1756.1 1780.5 1261.0 1279.1 1591.1 714.56 1143.0 True False 1409.0814208244199 1215.2504481289996 1435.3589026706495 1449.4301010796698 1619.4540893728056 1248.3154848963923 1182.616457190682 1548.8988593788147 1212.5561306024927 1289.7151837628212 1.0925524011536722 0.9422626510323261 1.1129270405911669 1.123837355198743 1.2556680031074392 0.9679001229204398 0.9169593969889753 1.2009619479393967 0.9401735715515015 1.0 10.332836785705346 AASEDMT(ph)SDEER ddPTM_A459_Selumetinib_30min_R2 2 AASEDMTSDEER 12 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 AASEDMT(0.63)S(0.37)DEER;AASEDMT(0.5)S(0.5)DEER 197.38 0.00028903 4852800.0 40655.0 39064.0 43366.0 41577.0 48966.0 27567.0 23428.0 13447.7 10361.3 10739.5 True False 38395.55785485971 42060.0831894426 40575.878773330776 35914.14087567449 42814.45331840589 31364.10402168956 24517.44842170131 13486.830580613421 12433.849518910774 10429.42273042796 3.681465297483842 4.032829455338101 3.8905201008824957 3.443540625781193 4.1051604125216095 3.007271335371653 2.3507963053574743 1.2931521647181334 1.1921896197221804 1.0 13.34837168630484 -7.415979783763356 1.319588416988817 1.0297723273206234 3.844652836900326 0.9655227711550461 0.21926070754597957 0.07078504060635363 0.2358739923635456 0.1447334610741111 0.07351899245964108 3.8372510732877084e-08 7.415979783763356 2.8148805095797025 up AASEQQADTS(ph)GGDSPK ddPTM_A459_Selumetinib_30min_R2 2 AASEQQADTSGGDSPK 16 0 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 1 AASEQQADT(0.057)S(0.943)GGDSPK;AASEQQADT(0.043)S(0.956)GGDS(0.001)PK 163.41 3.2193e-05 10573000.0 34870.0 27250.0 34995.0 36925.0 35434.0 33267.0 39839.0 40141.0 32151.0 33481.0 True False 32932.06499566986 29339.987377439866 32743.459799675104 31895.75130082212 30982.4641360208 37849.22728224131 41691.59243948086 40257.803664299696 38582.09837399749 32514.31653591493 1.0128481390434116 0.9023713398690469 1.0070474574948258 0.980975603949431 0.9528868337674555 1.1640788217225324 1.2822533850105329 1.2381562324962727 1.1866187724223007 1.0 14.988787477613043 -6.8125049426934625 5.092375058338772 1.1992476864001507 0.9695668911304761 0.6387300259645345 0.07544985924054627 0.11080252638865555 6.13908856305147 0.02554020487275491 0.022898620060146965 1.5399090002981066e-07 6.8125049426934625 -0.22968079526967455 AASEQQADTS(ph)GGDSPKV ddPTM_A459_Selumetinib_30min_R1 1 AASEQQADTSGGDSPKV 17 1 U3KQ26 U3KQ26 FOXK1 1 AASEQQADT(0.104)S(0.843)GGDS(0.053)PKV 186.17 9.899600000000001e-14 0.0 796.83 908.06 886.62 869.22 620.59 633.76 568.92 673.77 476.71 701.57 True False 815.3945886387243 801.743913054359 766.2218738550491 717.4270442802062 564.4577440740635 627.3849498080397 526.00590635988 655.8994308865971 808.942052479168 791.6233433705012 1.0300284794117012 1.012784577120689 0.9679121772643793 0.9062732299247408 0.7130382760957593 0.7925296229098269 0.6644648755812333 0.8285498859772992 1.0218774613630377 1.0 9.628670344944783 -5.851718450546008 2.6719452811979885 0.81708695245306 1.0116129638947766 0.3196813115446072 0.10621502789910837 0.29345683514852355 4.245927448470027 0.032334302333900763 0.05416210466906108 1.406959348426916e-06 5.851718450546008 0.19452601144171666 AASEQQADTSGGDS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AASEQQADTSGGDSPK 16 0 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 1 AASEQQADTS(0.001)GGDS(0.998)PK 213.69 1.8826e-08 1715800.0 529.77 783.04 525.48 485.44 540.81 537.08 678.97 802.28 407.3 692.79 True False 542.1126102470247 691.3613127745803 454.1227022550261 400.66701683737546 491.8938309877607 531.6774628296228 627.7547462581168 781.0009282272865 691.1583519849911 781.7163448460585 0.6934901819838264 0.8844145543748716 0.5809302891632071 0.5125478307816089 0.629248491771818 0.6801411616055242 0.8030467194359855 0.9990848130226663 0.8841549195457838 1.0 9.610501393059835 -7.493027653242887 2.58672201404035 0.9572010999691339 0.6604293610715951 0.6605781819499135 0.09542074619502153 0.19583352249186758 2.6070771790465215 0.055564157854403357 0.031137377000608098 3.213455918710979e-08 7.493027653242887 -0.29677173889753883 AASEQQADTSGGDS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AASEQQADTSGGDSPK 16 0 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 1 AASEQQADTSGGDS(1)PK;AASEQQADTSGGDS(0.999)PK 237.16 1.6251999999999994e-64 2464000.0 15439.4 10608.4 12367.5 12809.8 13170.3 9843.0 17324.4 16464.9 12080.5 13150.6 True False 14581.339956815164 11422.030168617726 11571.788514715867 11065.083141862453 11515.729170024117 11198.78390414229 18130.018927647357 16512.81013308908 14496.9375573723 12770.908008637816 1.1417621947439314 0.8943788617764881 0.9061053847454774 0.866428850194395 0.9017157716769443 0.8768980166929248 1.419634290324918 1.2930020419785628 1.1351532363687105 1.0 13.640573483524161 -7.245169099669001 24.927395446447388 1.2363642341190988 0.924113444810627 0.5420243772513373 0.1255170854436184 536.0380161182594 821254.9516122291 0.047166582877062574 0.03642147605937329 5.686314817542849e-08 7.245169099669001 -0.31225078930847183 AASEQQADTSGGDS(ph)PKV ddPTM_A459_Selumetinib_30min_R1 1 AASEQQADTSGGDSPKV 17 1 U3KQ26 U3KQ26 FOXK1 1 AASEQQADTSGGDS(1)PKV 246.42 4.4917999999999996e-30 5598600.0 1292.9 1589.6 1653.4 1826.1 1610.0 1510.6 1468.7 1533.4 1032.0 1385.7 True False 1323.0220544545334 1403.4888930150091 1428.877361476099 1507.2059151424096 1464.3757842685868 1495.4047355150594 1357.9147765428456 1492.7292508148294 1751.2286257022108 1563.5680928610172 0.8461557002187653 0.8976192974409607 0.9138568176212517 0.9639528473521891 0.9365602885826813 0.9564052517717777 0.8684717875370128 0.9546941112640851 1.120020697338363 1.0 10.6106263341737 -1.522878745280402 0.15112146873218266 1.0411344511028624 0.3745367077622486 0.42630808170128265 0.055217933965383194 74.40188299511581 0.7384335175083644 0.20103566709385257 10.88652027391986 0.029999999999995548 1.522878745280402 -0.6665977433406138 AASEQQADTSGGDS(ph)PKV ddPTM_A459_Selumetinib_30min_R2 2 AASEQQADTSGGDSPKV 17 1 U3KQ26 U3KQ26 FOXK1 1 AASEQQADTSGGDS(1)PKV;AASEQQADT(0.002)S(0.007)GGDS(0.991)PKV 140.27 0.00090564 21802000.0 63979.0 50464.0 55800.0 60375.0 58926.0 46461.0 55797.0 60637.0 38617.0 54254.0 True False 60423.30330822945 54334.426532665144 52209.888750446364 52151.82084731579 51523.18907487613 52860.58101903431 58391.67105965797 60813.44363100427 46341.47904913259 52687.54605117914 1.1468232597042196 1.0312574907149077 0.9909341516822819 0.9898320334877058 0.9779007172744013 1.0032841720828503 1.1082632507298407 1.1542280517663865 0.8795528074911259 1.0 15.685174366582176 AASGEDSTEEALAAAAAPWEGGPVPGVDRS(ph)PFAK ddPTM_A459_Selumetinib_30min_R1 2 AASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAK 34 1 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 AASGEDSTEEALAAAAAPWEGGPVPGVDRS(1)PFAK;AASGEDSTEEALAAAAAPWEGGPVPGVDRS(1)PFAK 134.64 8.814800000000001e-26 14890200.0 3320.33 4047.1 4405.5 4226.8 4154.67 3489.2 3679.6000000000004 3403.4300000000003 2049.39 3048.3900000000003 True False 3397.687228762488 3573.2636505542546 3807.2572976792985 3488.6687268626747 3778.880832066566 3454.101815940123 3402.0448095370434 3313.1599805013147 3477.6651484766035 3439.680550333112 0.9877915053575085 1.0388359030050642 1.106863629330517 1.0142420715565632 1.0986138906709242 1.0041926177143439 0.9890583615991828 0.9632173488263192 1.0110430598387437 1.0 11.748058869981776 -6.979486698450766 23.44823669257573 0.9890303230785961 1.0500894999549903 0.3942197307837705 0.03484514998723291 114.24340698141917 130587.5479051516 0.01211934370455677 0.010686558842472197 1.0483669024172841e-07 6.979486698450766 0.06105917687639428 AASGEDSTEEALAAAAAPWEGGPVPGVDRS(ph)PFAK ddPTM_A459_Selumetinib_30min_R2 3 AASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAK 34 1 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 AASGEDSTEEALAAAAAPWEGGPVPGVDRS(1)PFAK;AASGEDSTEEALAAAAAPWEGGPVPGVDRS(1)PFAK;AASGEDSTEEALAAAAAPWEGGPVPGVDRS(1)PFAK 145.43 2.5772e-27 10879900.0 34156.5 34354.6 37561.1 40175.7 41802.8 31766.8 32362.5 31540.2 30330.1 43825.4 True False 32258.21846930303 36989.48735255026 35144.45971943351 34703.70035305183 36551.15854222638 36142.38834970102 33867.42037507721 31631.97676023882 36396.96749380054 42560.04682993595 0.7579460285418012 0.8691129382529847 0.8257617727693275 0.8154055960446427 0.8588138703953909 0.8492093181692444 0.7957561820927201 0.7432317188614904 0.8551909644093622 1.0 15.377212117824623 -8.548272553581223 22.994068513869546 1.0000000011387475 0.8174435812340314 0.6735505099914465 0.03870572773096624 1564.7096005881308 1416841.364308208 0.03806675918945799 0.009828794896939278 2.8296156344632256e-09 8.548272553581223 -0.18255641990471616 AASGEDSTEEALAAAAAPWEGGPVPGVDT(ph)SPFAK ddPTM_A459_Selumetinib_30min_R1 1 AASGEDSTEEALAAAAAPWEGGPVPGVDTSPFAK 34 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;Q5SRD0 A0A0A0MR88 FAM21C;FAM21D WASH complex subunit FAM21C;Putative WASH complex subunit FAM21 1 AASGEDSTEEALAAAAAPWEGGPVPGVDT(0.602)S(0.398)PFAK 131.39 4.6671e-25 6836400.0 3445.7 3570.3 3905.1 3951.5 3397.2 3223.9 3616.0 3541.0 2135.6 3353.7 True False 3525.9781058349363 3152.287616212562 3374.808869178853 3261.4447038416447 3089.923859824376 3191.4704930669955 3343.2422087416985 3447.081177210978 3623.957221947325 3784.1800628043534 0.9317680573640381 0.8330173416421647 0.8918203714328207 0.8618629794864139 0.8165372177175197 0.8433717318149716 0.8834786276697711 0.9109189097773638 0.9576598263830258 1.0 11.8857650227935 -8.19417822215341 1.3988817721716824 0.9973744895308541 0.8613032128969869 0.6947403307697793 0.030474403448758014 0.22350355104566744 0.8190192203584014 0.028423774920672707 0.008973813278094885 6.394723602873747e-09 8.19417822215341 -0.1360712766338672 AASGFNAMEDAQTLR ddPTM_A459_Selumetinib_30min_R1 2 AASGFNAMEDAQTLR 15 0 P09525;Q6P452;B4E1S2 P09525 ANXA4 Annexin A4;Annexin 0 ; 224.66 7.6097e-08 34495000.0 3755.2 4720.1 4102.8 4708.1 4582.0 3250.4 4205.9 4304.7 2070.32 3266.2 False True 3842.688853652769 4167.46849768504 3545.66229506722 3885.9187169826264 4167.558909017804 3217.7039271270683 3888.6455768104843 4190.525372363763 3513.181829809884 3685.4485854821755 1.042665163961315 1.1307900248837146 0.9620707528072415 1.0543950422453723 1.130814556858769 0.8730833852362884 1.055134941273838 1.137046217079571 0.953257588139775 1.0 11.84762451664531 -5.249009078799534 24.96783511385522 1.0267100550846362 1.086727585461907 0.09680556289348152 0.07896665975175142 2035.7526255762775 4089046.100678044 0.019841895716729455 0.05169461583020971 5.6362587326823295e-06 5.249009078799534 0.060017530377270756 AASGGS(ph)GSENVGPPAAAVPGPLSR ddPTM_A459_Selumetinib_30min_R2 1 AASGGSGSENVGPPAAAVPGPLSR 24 0 Q9UL54-2 Q9UL54-2 1 AAS(0.418)GGS(0.522)GS(0.06)ENVGPPAAAVPGPLSR 86.073 9.9874e-05 7966400.0 25421.0 15941.0 19208.0 23240.0 26238.0 20046.0 20521.0 28250.0 18358.0 18907.0 True False 24008.202588325872 17163.623441606196 17972.178192089137 20074.671908763863 22941.747869303876 22807.154540529933 21475.267161590084 28332.20282296074 22030.112965377313 18361.105783714444 1.307557555145735 0.9347815781786756 0.978817855732291 1.0933258674741302 1.249475284307347 1.2421449344711555 1.169606417748422 1.5430553669643499 1.1998249574335076 1.0 14.164365326135703 -6.22487415290619 3.8132082429166605 1.259838814381245 1.0568361815518625 0.17934103449136907 0.15615347827679826 0.31812049741153353 10.025025306536243 0.04739298500767842 0.060259788656995696 5.958347757287866e-07 6.22487415290619 -0.20300263282938236 AASGGSGS(ph)ENVGPPAAAVPGPLSR ddPTM_A459_Selumetinib_30min_R1 1 AASGGSGSENVGPPAAAVPGPLSR 24 0 Q9UL54-2 Q9UL54-2 1 AAS(0.038)GGS(0.128)GS(0.834)ENVGPPAAAVPGPLSR 293.56 2.864499999999999e-100 6989500.0 589.13 289.76 531.66 460.9 476.67 395.87 551.36 491.72 315.13 381.0 True False 602.8555827525712 255.83476449423054 459.46349219933654 380.4124671645234 433.555282662924 391.8879072212015 509.7704712975171 478.67798826833695 534.7525938154437 429.90506125427373 1.4022993378903332 0.5950959585072512 1.0687557175038236 0.8848755259001773 1.0084907616532834 0.911568489279575 1.1857745284743362 1.1134504601359316 1.2438853179706026 1.0 8.74787428498419 -7.263386464863879 24.84919466757463 1.1452317856760463 0.9622943323391013 0.13009440059710498 0.19594706893466615 281.85852844816213 3597108.6874755863 0.07334390649229484 0.052239531606657244 5.452724245262621e-08 7.263386464863879 -0.182937453336945 AASIENVLQDS(ph)SPEHCGR ddPTM_A459_Selumetinib_30min_R2 2 AASIENVLQDSSPEHCGR 18 0 K7EPJ5;O60291-4;O60291;O60291-3;O60291-2 K7EPJ5 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 AASIENVLQDS(0.87)S(0.13)PEHCGR;AASIENVLQDS(0.797)S(0.203)PEHCGR 171.83 3.9539e-08 12291300.0 101983.0 64201.0 95398.0 116488.0 88363.0 73678.0 107567.0 102770.0 110277.0 85209.0 True False 96315.1931302953 69125.01026124838 89260.19654148874 100622.13344699172 77262.0499647572 83826.47571770752 112569.07863996687 103069.04368551065 132335.4813968251 82748.79477043032 1.163946778892698 0.8353597227974333 1.0786887807746683 1.215995154082272 0.9336939610915787 1.0130235243941257 1.3603712169133926 1.245565497013639 1.5992436115107531 1.0 16.33645067888458 -7.259489884443034 24.814775873046155 1.321758881784811 1.0357209639983822 0.35854989010162774 0.170199616702223 159.80664668497667 2034167.0065817977 0.06452553247307237 0.04739902361557042 5.501867352727719e-08 7.259489884443034 -0.28603791778642873 AASIENVLQDSS(ph)PEHCGR ddPTM_A459_Selumetinib_30min_R1 1 AASIENVLQDSSPEHCGR 18 0 K7EPJ5;O60291-4;O60291;O60291-3;O60291-2 K7EPJ5 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 AASIENVLQDS(0.085)S(0.915)PEHCGR 224.38 4.1774e-15 15650000.0 4118.3 4527.0 4720.8 4469.2 4969.4 4347.3 4086.0 4440.3 1954.8 3998.4 True False 4214.248377183162 3996.976735454795 4079.741289498228 3688.7381172742184 4519.91864741883 4303.570109032586 3777.7897303425293 4322.5288198728895 3317.1528270568638 4511.633587714142 0.9340848043731201 0.885926717617132 0.9042714152603124 0.8176058728082901 1.0018363769006529 0.953882895266995 0.8373440920889542 0.9580850784611115 0.7352442884745718 1.0 12.13943418869021 -10.538279845947223 4.0991962954828205 1.0000092994063927 0.8954057964051048 0.1578760916457731 0.07444188885980545 63433612118.690735 172684903700.626 9532000.472575072 0.01776541005097148 2.895477230378832e-11 10.538279845947223 -0.10460350300128796 AASIENVLQDSS(ph)PEHCGR ddPTM_A459_Selumetinib_30min_R2 2 AASIENVLQDSSPEHCGR 18 0 K7EPJ5;O60291-4;O60291;O60291-3;O60291-2 K7EPJ5 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 AASIENVLQDS(0.21)S(0.79)PEHCGR;AASIENVLQDS(0.072)S(0.928)PEHCGR 200.27 1.0958e-10 9825800.0 124999.0 75750.0 117810.0 139130.0 116266.0 93880.0 129081.0 115164.0 105367.0 99689.0 True False 118052.05599064338 81559.78142536027 110230.23286182959 120180.2539873633 101659.62564877231 106811.11784221049 135083.5222691491 115499.10817357361 126443.3441999627 96810.71954687206 1.2194109964598194 0.8424664314768586 1.1386159856859686 1.2413940785676798 1.0500864586545358 1.1032984605645515 1.395336414205111 1.1930404888443509 1.3060882595624512 1.0 16.56287918098407 -7.045190774839291 24.54882954942411 1.2410765809262996 1.0925891100029725 0.15626801951825886 0.13898237696218235 570.7420327317027 310040.285385176 0.05151179501437095 0.03990293567059098 9.011751866451545e-08 7.045190774839291 -0.14848747092332704 AASLNYLNQPS(ph)AAPLQVSR ddPTM_A459_Selumetinib_30min_R1 1 AASLNYLNQPSAAPLQVSR 19 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 AAS(0.002)LNYLNQPS(0.998)AAPLQVSR 197.51 2.8408e-15 111810000.0 1067.2 1441.0 1823.1 1600.3 1739.4 1345.3 1738.3 1576.3 884.58 1406.2 True False 1092.0636835902849 1272.2870500972754 1575.5330335714746 1320.8376463514571 1582.0715771160114 1331.7675034346687 1607.1786314866415 1534.4914034559915 1501.0676528330064 1586.699467547927 0.6882612025312844 0.8018450097947394 0.9929624770129223 0.8324434925239304 0.9970833226287852 0.8393319155093508 1.0129067692764546 0.9670964381348048 0.9460314845587896 1.0 10.631813181747008 -4.058302970362183 0.8588155314870441 0.9523009261736003 3.6503942582524786e-14 0.6358378843503163 0.06315888956586758 4.251892940193637 0.9972320782062316 0.020875994443858816 5.138202182283679 8.743735862496982e-05 4.058302970362183 -0.9523009261735638 AASLNYLNQPS(ph)AAPLQVSR ddPTM_A459_Selumetinib_30min_R2 1 AASLNYLNQPSAAPLQVSR 19 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 AAS(0.116)LNY(0.004)LNQPS(0.88)AAPLQVSR 146.67 4.4932e-05 74679000.0 29307.0 25286.0 29427.0 33845.0 32313.0 23666.0 21937.0 26458.0 21732.0 26134.0 True False 27678.23426521641 27225.354892695188 27533.698857695057 29235.252614118446 28253.55205811479 26925.776681441777 22957.113967340847 26534.988399642305 26079.00724281402 25379.443515713414 1.0905768776245912 1.0727325394600908 1.0848818982436654 1.1519264634789077 1.1132455304081788 1.0609285686177858 0.9045554506790976 1.0455307415709665 1.0275641870030554 1.0 14.631372815713407 -7.011112849382668 18.67316288059934 0.9959973728825996 1.101190624762986 0.6235150343191678 0.03966812250397938 13.185744553108572 22156.351686948077 0.015024397170115639 0.012376515859737041 9.747363241489458e-08 7.011112849382668 0.10519325188038631 AASLTEDRDR ddPTM_A459_Selumetinib_30min_R1 1 AASLTEDRDR 10 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 148.94 0.0021618 8535500.0 1929.5 1674.7 2237.2 2377.4 2245.6 1825.7 1986.6 1569.1 1095.0 1397.0 False True 1974.4535958465656 1478.6253454530925 1933.4005280599545 1962.2317193250979 2042.4858764928804 1807.33511560297 1836.749162579163 1527.4823708448869 1858.135024364264 1576.318557932338 1.2525727023327458 0.9380244481753801 1.226529065670585 1.244819271746038 1.2957316693473528 1.1465544870407776 1.1652144506808526 0.9690188338888113 1.1787814176352687 1.0 10.622343402900333 -7.628662157692825 8.187947984198917 1.0558330287223827 1.1803970300218258 0.2494300885090701 0.10510453099126649 0.3854390813622335 27.00679440644668 0.05049485169543544 0.029018401997212957 2.3514613363860514e-08 7.628662157692825 0.12456400129944312 AASLTEDRDR ddPTM_A459_Selumetinib_30min_R2 1 AASLTEDRDR 10 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 104.01 0.038342 9208300.0 19820.0 17429.0 20885.0 22487.0 19947.0 13637.0 15885.0 18153.0 14785.0 22912.0 False True 18718.48374574639 18765.748256932075 19541.281837868675 19424.23180776131 17441.079531557465 15515.37296563938 16623.683975530348 18205.82222460908 17742.41312741603 22250.47102747477 0.8412623590140137 0.8433865617388604 0.8782412657124965 0.8729807015670079 0.7838521490183874 0.6973053714899372 0.7471160477907863 0.8182218795336342 0.7973949452803848 1.0 14.44154825683339 -6.26554244520767 24.105730681889618 0.7897157206638181 0.8592314647682616 0.07431870212822067 0.07523576342646762 397.98915512944905 2338203.1772429477 0.02231418837804308 0.026236904705132822 5.425722211456198e-07 6.26554244520767 0.0695157441044435 AASPYSQRPAS(ph)PTAIR ddPTM_A459_Selumetinib_30min_R1 4 AASPYSQRPASPTAIR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AASPYS(0.001)QRPAS(0.947)PT(0.052)AIR;AASPYSQRPAS(0.972)PT(0.028)AIR;AASPYS(0.001)QRPAS(0.757)PT(0.242)AIR;AASPYS(0.002)QRPAS(0.936)PT(0.061)AIR 252.1 6.8865e-29 31069300.0 5395.32 5791.5 5687.360000000001 5599.889999999999 6101.599999999999 4990.0 5971.0 5536.199999999999 2594.86 4057.85 True False 5521.020458534792 5113.428487604692 4915.047750432267 4621.974334454203 5549.711357324971 4939.805130557495 5520.602662720322 5389.361991888002 4403.287898924072 4578.714574306184 1.2058014031965285 1.1167825389901125 1.073455807447235 1.0094480141633582 1.2120675502394518 1.0788628665079059 1.2057101557934222 1.1770469428539683 0.9616864793524076 1.0 12.160726918451122 -8.267698951054784 24.97573950391757 0.9808432157657186 1.131128426306155 0.4764447205289555 0.06449949991992435 486.5202456852626 1941190.871142127 0.05835005662010397 0.016539715930304618 5.398847359734745e-09 8.267698951054784 0.1502852105404363 AASPYSQRPAS(ph)PTAIR ddPTM_A459_Selumetinib_30min_R2 2 AASPYSQRPASPTAIR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AASPYSQRPAS(0.807)PT(0.193)AIR;AASPYS(0.001)QRPAS(0.997)PT(0.002)AIR 182.49 4.3483e-06 27388000.0 30050.0 22415.5 27584.0 30553.0 27838.0 18108.5 25035.0 23944.0 21319.0 20154.0 True False 28379.94129968106 24134.696772807452 25809.275471188408 26391.628693135204 24340.74156512241 20602.781502403803 26199.177105911374 24013.67307585742 25583.395702629845 19572.10165361936 1.4500201256839944 1.233117280910114 1.3186767536748227 1.3484310045086418 1.2436447549627974 1.0526606629694182 1.3385980498965222 1.2269338010216548 1.3071358485356552 1.0 14.256511060524788 -14.522878745280334 0.12256685155330169 0.1645854985977167 1.3938018146699318 0.4550831076677395 0.09562006725223797 151.02821190678807 1.187504972741037 31.693207255592807 0.8819602308657387 3.000000000000026e-15 14.522878745280334 1.2292163160722152 AASS(ph)SSPGSPVASSPSR ddPTM_A459_Selumetinib_30min_R1 2 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AAS(0.037)S(0.481)S(0.481)SPGSPVASSPSR;AASS(0.917)S(0.081)S(0.001)PGSPVASSPSR 267.5 1.8927999999999996e-51 21960000.0 3727.6299999999997 4649.34 4603.6 4889.3 4454.6 4173.8 4277.4 4054.0 2365.31 3267.3999999999996 True False 3814.476526294652 4104.993111380475 3978.4564057647085 4035.4755385278904 4051.6822165235053 4131.81536150719 3954.752274245503 3946.4747507521306 4013.7583145927315 3686.802617171166 1.034629982231446 1.1134290434376932 1.0791075137126067 1.0945732542699171 1.0989691169396822 1.1207042498731532 1.0726780587130893 1.0704328819697453 1.0886827235878536 1.0 11.848154464627596 -9.812775284826726 0.7018460725631138 0.9944339171928342 1.0892516384472417 0.5520646762619184 0.023140554426314408 6.658034130076893 2.8374641839688217 0.12556549996443703 0.008158252192559716 1.5389507271510325e-10 9.812775284826726 0.09481772125440746 AASS(ph)SSPGSPVASSPSR ddPTM_A459_Selumetinib_30min_R2 1 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AAS(0.267)S(0.362)S(0.362)S(0.006)PGS(0.004)PVASSPSR 217.32 9.4785e-12 16412000.0 40484.0 35362.0 40039.0 49296.0 43864.0 39221.0 32946.0 39429.0 40543.0 46671.0 True False 38234.061350292446 38074.15169324873 37462.93433116707 42581.79975965677 38353.41217086459 44623.33673721069 34478.05428126052 39543.73186217768 48652.73286606886 45323.48696417925 0.8435816374964745 0.8400534522716683 0.8265677872661331 0.9395084670627984 0.8462149481388457 0.984552154437678 0.7607105408396698 0.8724777044058964 1.0734552022557495 1.0 15.467971238775144 -8.251431166078683 23.005615201647963 1.036727594270155 0.8646202253987421 0.566890184599137 0.06031716653279754 143.61356264787324 330126.2967759914 0.040790688597110714 0.014947432398130421 5.604912459232344e-09 8.251431166078683 -0.17210736887141298 AASSLNLS(ph)NGETESVK ddPTM_A459_Selumetinib_30min_R1 2 AASSLNLSNGETESVK 16 0 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819;O95819-6;E7EN19 G5E948;O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 AASSLNLS(1)NGETESVK;AASSLNLS(1)NGETESVK 320.0 1.9588999999999994e-117 36713000.0 4525.7 4683.7 5172.9 5061.2 4723.1 3762.1000000000004 3972.2 3743.6000000000004 2348.0 3739.3999999999996 True False 4631.140004520755 4135.330226606944 4470.448592705764 4177.356430490533 4295.89643893103 3724.256689713495 3672.573755963434 3644.3075670734315 3984.3845088651074 4219.388414840501 1.09758560938169 0.9800781108613025 1.0595015564298915 0.9900383704419975 1.0181324913870062 0.8826532007848528 0.8704042849068357 0.8637051650081832 0.9443037988280873 1.0 12.04281818529622 -6.75204111369552 19.668465801310756 0.9010817795466223 1.0258686656512077 0.581902743883704 0.049036328923029227 9.524532355132179 19931.85057496503 0.015546944607860463 0.01525034911738403 1.7699413939592904e-07 6.75204111369552 0.12478688610458544 AASSLNLS(ph)NGETESVK ddPTM_A459_Selumetinib_30min_R2 4 AASSLNLSNGETESVK 16 0 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819;O95819-6;E7EN19 G5E948;O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 AASSLNLS(0.958)NGET(0.041)ES(0.001)VK;AASSLNLS(0.88)NGET(0.055)ES(0.065)VK;AASSLNLS(0.99)NGET(0.01)ESVK;AASSLNLS(0.946)NGET(0.054)ESVK 175.26 1.5013e-06 34726800.0 162838.0 135425.0 153542.0 162693.0 140442.0 126867.0 153845.0 145917.0 114375.0 138549.0 True False 153788.11585216186 145811.66203999255 143663.2748838894 140533.93273892094 122798.42039259001 144341.77766603875 160999.09733808428 146341.59431214025 137253.1959045119 134548.73037646676 1.1429919511084452 1.0837089404858162 1.067741586872802 1.044483529095426 0.9126687412731473 1.0727843901772323 1.1965857789041152 1.0876475303979243 1.0201002679139228 1.0 17.037769251976144 -9.133610910723277 0.006455347566993312 1.095513510233938e-05 2.0941830741179857 0.07628667911444864 0.07072417811902429 26273.082475921914 65.84784274516606 10868.075308378564 10489.701342647515 7.351722222042962e-10 9.133610910723277 2.0941721189828835 AASSS(ph)SPGSPVASSPSR ddPTM_A459_Selumetinib_30min_R2 1 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AAS(0.005)S(0.061)S(0.842)S(0.061)PGS(0.031)PVASSPSR 301.75 2.951099999999999e-89 13243000.0 39081.0 30126.0 45439.0 42668.0 36432.0 30680.0 33436.0 36954.0 32940.0 43981.0 True False 36909.03447363849 32436.567329642316 42515.504210242514 36856.54479359453 31855.0864537876 34905.89151468913 34990.84025217709 37061.53002193598 39528.920420499424 42711.15425363862 0.8641544607868835 0.7594401953414547 0.9954192283768721 0.8629255153050487 0.7458259326033977 0.8172546990278412 0.8192436112680372 0.8677248524319302 0.9254940802058025 1.0 15.382325266372842 -8.43659621335004 1.8439090859315372 0.9984089521093198 0.837625696165348 0.39067969557659876 0.06466145540954453 0.3576404144310462 2.6123115022255505 0.06377618868122452 0.01824121179764973 3.6593486257815274e-09 8.43659621335004 -0.1607832559439718 AASSSS(ph)PGSPVASSPSR ddPTM_A459_Selumetinib_30min_R2 1 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AAS(0.001)S(0.009)S(0.115)S(0.502)PGS(0.373)PVASSPSR 95.9 0.0062088 4901600.0 8659.7 6569.4 10956.0 11603.0 12622.0 7117.8 7865.2 10215.0 9682.2 11517.0 True False 8178.428541525731 7073.251856049669 10251.102887990864 10022.65138370857 11036.311517888316 8098.212341044797 8230.94738459813 10244.723958815715 11618.910543271399 11184.474285240349 0.7312304836999302 0.632417016272631 0.9165475843168407 0.8961218138732738 0.9867528179176418 0.724058380797714 0.7359261754001387 0.9159772464527206 1.0388427964472462 1.0 13.449209825137238 -1.8393354196676712 0.1503471235180549 1.017180173086481 6.87165124415173e-17 0.3510204297048144 0.10732477349798891 85.63097895195529 0.92228721065827 0.42881012054743944 18.663168701649678 0.014476533521912645 1.8393354196676712 -1.017180173086481 AASSSSPGS(ph)PVASSPSR ddPTM_A459_Selumetinib_30min_R1 2 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AAS(0.029)S(0.057)S(0.341)S(0.194)PGS(0.379)PVASSPSR;AAS(0.015)S(0.176)S(0.176)S(0.028)PGS(0.605)PVASSPSR 262.73 1.9893999999999996e-40 26252000.0 4686.700000000001 5996.4 5951.700000000001 7352.8 6411.1 5270.9 5865.5 5949.700000000001 2983.3999999999996 4202.9 True False 4795.890991269288 5294.33870034927 5143.491830347951 6068.771509150157 5831.217136971638 5217.879531594289 5423.060612658855 5791.894628650709 5062.611901085248 4742.383154712827 1.011282900350067 1.1163878007385228 1.0845795589579292 1.2796881464795202 1.229596375226823 1.1002652804231834 1.1435306755569914 1.2213046562665253 1.0675248574240968 1.0 12.211396512870683 -8.509464633349289 6.707153594073771 1.0000337595347357 1.150295203391359 0.29545175548306324 0.07444673578269914 0.16759692413061195 41.42085564420735 0.07528110735042717 0.019485736562536975 3.094107272960297e-09 8.509464633349289 0.1502614438566232 AASSSSPGS(ph)PVASSPSR ddPTM_A459_Selumetinib_30min_R2 1 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AAS(0.001)SS(0.014)S(0.014)PGS(0.971)PVASSPSR 190.24 7.449399999999999e-08 7358800.0 7669.2 6273.3 12368.0 9846.7 16299.0 9197.4 6988.9 8085.9 9653.7 8302.2 True False 7242.976566240069 6754.441938161226 11572.256345260232 8505.562473495056 14251.373905091239 10464.258364315574 7313.897698242622 8109.428630307194 11584.709746914861 8062.493914293866 0.8983543607269101 0.8377608727476228 1.4353196998690398 1.0549542813813082 1.7676136015216344 1.297893489973823 0.9071507868397805 1.0058213645197447 1.4368643089920994 1.0 12.977010451115248 -5.244556363717864 24.26215898991176 1.2410816467878318 0.8680574968428204 0.2617828705211447 0.24859194888880803 781.8326841722512 1123545.1102456339 0.0652554502681713 0.17154222342563225 5.6943431686151515e-06 5.244556363717864 -0.37302414994501143 AASSSSPGSPVAS(ph)SPSR ddPTM_A459_Selumetinib_30min_R2 1 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AASSSSPGSPVAS(0.554)S(0.41)PS(0.035)R 103.6 0.0052368 0.0 5704.7 7890.0 6246.4 8678.3 8852.4 5253.9 5936.8 5929.4 5511.2 6462.2 True False 5387.655611723483 8495.137629651397 5844.513424566093 7496.300569097482 7740.2823705398905 5977.577034844371 6212.872963546021 5946.65357233499 6613.593995794065 6275.619495188002 0.8585057803225022 1.3536731530911443 0.931304619256717 1.1945116453993858 1.233389369204898 0.952507882198377 0.9900015398176877 0.9475803268338281 1.053855161369362 1.0 12.615542165800623 -6.784238791965183 24.984226988712944 0.9855885053184131 1.1218691014760893 0.1745644227337504 0.1358485869451209 379.68539110327146 416066.77455660386 0.04492170613798709 0.03964414862292448 1.6434678323279747e-07 6.784238791965183 0.13628059615767618 AASSSSPGSPVASS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AASSSSPGSPVAS(0.002)S(0.998)PSR;AASSSSPGSPVAS(0.002)S(0.998)PSR 292.38 6.455699999999999e-76 73799000.0 8051.8 9600.3 10609.099999999999 11135.5 9466.2 8131.599999999999 8606.3 9267.5 4082.0 6507.8 True False 8239.391273924528 8476.292412941617 9168.442491614898 9190.89396422337 8609.983881393357 8049.803486902065 7957.1198620281175 9021.695794917465 6926.855862515914 7343.139521340058 1.122052937981071 1.154314498357069 1.2485725574150248 1.251630033381977 1.1725208075335753 1.0962345824300839 1.0836127842735055 1.2285883672371085 0.943309853011185 1.0 12.84218129643293 -8.09094366806838 0.7512265000184319 0.9832044002891742 1.18733579318264 0.47667132163548465 0.07090952915475597 0.5837271788432381 0.6873530042360974 0.06899978610131617 0.028970596413643353 8.110662536775015e-09 8.09094366806838 0.20413139289346582 AASSSSPGSPVASS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 4 AASSSSPGSPVASSPSR 17 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 AASSSSPGSPVAS(0.025)S(0.974)PS(0.001)R;AASSSSPGSPVAS(0.025)S(0.974)PS(0.001)R;AASSSSPGSPVAS(0.005)S(0.995)PSR;AASSSSPGS(0.001)PVAS(0.309)S(0.684)PS(0.007)R 265.43 5.852199999999999e-41 55265700.0 85640.0 69866.0 95717.0 103204.0 118108.0 72093.0 80658.0 87443.0 68973.0 82696.0 True False 80880.47164408283 75224.49754540247 89558.67242878987 89147.43716316966 103270.2171410832 82023.156354905 84408.75682079497 87697.44465303203 82769.52726663953 80308.35160998821 1.0071240415551435 0.9366958235019551 1.1151850415723283 1.1100643379670876 1.285921265606442 1.021352757347637 1.0510582664019812 1.0920090239048663 1.0306465717115432 1.0 16.29326240713995 -5.265924069719371 24.718677029726457 1.09568276852744 0.9719099286598794 0.26078978307282874 0.07757101110041559 376.66800931220433 2076129.2759773515 0.02076213358319411 0.04564749024207057 5.420956599169127e-06 5.265924069719371 -0.1237728398675606 AASVAAATTS(ph)PTPR ddPTM_A459_Selumetinib_30min_R2 2 AASVAAATTSPTPR 14 0 Q9Y2D9 Q9Y2D9 ZNF652 Zinc finger protein 652 1 AASVAAAT(0.002)T(0.226)S(0.772)PTPR;AASVAAAT(0.005)T(0.148)S(0.847)PTPR 184.0 7.7708e-05 38376000.0 230390.0 187582.0 226100.0 247230.0 212870.0 188363.0 201070.0 210160.0 191385.0 207109.0 True False 217585.84612424357 201968.93622880452 211552.97215906638 213556.84750446133 186127.3675180548 214308.29346093215 210420.15341264658 210771.53080613932 229667.34774369467 201129.22503619394 1.0818211330804273 1.0041749834836755 1.051826118859637 1.0617892425431013 0.9254118464612017 1.065525377639011 1.0461938257594376 1.0479408488160296 1.1418894877279282 1.0 17.617763201785742 -7.50860131058785 1.9028561335008014 1.0710709733812545 1.027955582786221 0.06851519004489492 0.05236807708728647 0.830988549733649 5.9121724405323155 0.03112741965446537 0.015911030006552716 3.1002640861929855e-08 7.50860131058785 -0.04311539059503344 AAT(ph)PLPSLR ddPTM_A459_Selumetinib_30min_R1 3 AATPLPSLR 9 0 Q9Y3Q8 Q9Y3Q8 TSC22D4 TSC22 domain family protein 4 1 AAT(0.985)PLPS(0.015)LR;AAT(0.911)PLPS(0.089)LR;AAT(0.973)PLPS(0.027)LR 115.7 0.018905 35603000.0 10552.599999999999 11897.400000000001 12935.0 13965.3 13237.5 11044.2 12743.5 10883.6 6629.1 9656.6 True False 10798.455048214806 10504.446877048795 11178.498046869086 11526.522516148225 12040.170462270451 10933.10537533127 11782.247535149292 10594.931573084836 11249.09852969237 10896.118673249404 0.9910368427544417 0.9640540078585794 1.0259155927066892 1.0578558165346068 1.1049962673249658 1.0033944841453195 1.0813251845425826 0.9723583131575099 1.0323950084454891 1.0 13.411526700968757 -5.371318873460933 4.80497462991875 1.0384717292429415 0.9779598150272432 0.2704852869698011 0.03762964583572705 0.26901587499195767 9.524494274485832 0.01000755863399336 0.02175766454146983 4.2528603930754784e-06 5.371318873460933 -0.06051191421569835 AAT(ph)PLPSLR ddPTM_A459_Selumetinib_30min_R2 2 AATPLPSLR 9 0 Q9Y3Q8 Q9Y3Q8 TSC22D4 TSC22 domain family protein 4 1 AAT(0.999)PLPS(0.001)LR;AAT(0.999)PLPS(0.001)LR 115.23 0.019252 37467000.0 105891.0 88905.0 107683.0 116730.0 131347.0 89770.0 90609.0 94934.0 90394.0 91063.0 True False 100006.00213525887 95723.72762536856 100754.79301638565 100831.1726295184 114846.01560292156 102135.00264907569 94822.49803832744 95210.24222283026 108475.32581938777 88433.77457991181 1.1308575553889764 1.0824340369964565 1.1393248054264622 1.1401884982123416 1.2986668967651351 1.1549320735686 1.0722430257982776 1.0766275970364128 1.2266277939020427 1.0 16.432309847729258 -10.0989314055176 7.456640258672331 1.0000000024344406 1.1450036378810249 0.30336389532172914 0.0667183368777391 0.0 0.0 0.06835669082127678 0.016578932733753732 7.962851094446598e-11 10.0989314055176 0.14500363544658423 AAT(ph)SPAPGPSDATAR ddPTM_A459_Selumetinib_30min_R2 1 AATSPAPGPSDATAR 15 0 Q8IXZ2;Q8IXZ2-2 Q8IXZ2 ZC3H3 Zinc finger CCCH domain-containing protein 3 1 AAT(0.616)S(0.384)PAPGPSDATAR 150.9 0.0006005 5648800.0 18990.0 19261.0 20654.0 21547.0 20602.0 19160.0 15101.0 17710.0 16111.0 20549.0 True False 17934.611822993123 20738.256766123646 19325.1441263749 18612.261429351765 18013.79257578317 21799.116082837172 15803.226422063834 17761.53316795166 19333.650178951622 19955.6969772861 0.8987213948681717 1.0392148562752916 0.9684023639149809 0.9326790966277221 0.902689221844106 1.0923755811510507 0.7919155336970352 0.8900482497889263 0.9688286107449666 1.0 14.284513047179113 -7.266971013270602 24.96720903745978 0.9035354667524066 0.9702378661288206 0.12549954872486146 0.07548273096608794 888.5351174998441 4010410.8724107984 0.03022782345042977 0.021037661346259413 5.407904164788722e-08 7.266971013270602 0.06670239937641398 AAT(ph)SPGVGQSAPGTR ddPTM_A459_Selumetinib_30min_R1 2 AATSPGVGQSAPGTR 15 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 AAT(0.5)S(0.5)PGVGQSAPGTR;AAT(0.61)S(0.39)PGVGQSAPGTR 165.89 0.00019477 24997000.0 5840.4 8299.3 6537.700000000001 7467.5 6902.4 6380.8 7246.0 6894.6 3242.8999999999996 5897.5 True False 5976.469956559871 7327.614097760101 5649.916249015542 6163.441307335818 6278.079138717697 6316.614945302858 6699.428386211935 6711.732811182947 5502.964447955134 6654.501571514643 0.8981093313048172 1.1011514565007834 0.8490367292421505 0.9262063042736567 0.9434334143960135 0.9492243524807107 1.0067513418119256 1.008600379615701 0.8269536626922149 1.0 12.700114895617693 -8.221449600582254 24.999848704007064 0.9134761470147184 0.9607781071874776 0.05786408185591907 0.07557828011888261 1390.7135049734168 869415.2876199747 0.0491239125790377 0.018566630679232716 6.00551698256581e-09 8.221449600582254 0.04730196017275923 AAT(ph)SPGVGQSAPGTR ddPTM_A459_Selumetinib_30min_R2 2 AATSPGVGQSAPGTR 15 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 AAT(0.588)S(0.412)PGVGQSAPGTR;AAT(0.89)S(0.11)PGVGQSAPGTR 156.0 0.00039077 20942200.0 52686.0 51931.0 61627.0 64536.0 74486.0 58911.0 52275.0 61240.0 58069.0 67659.0 True False 49757.92303876863 55913.940715516634 57661.985914404286 55746.08546919039 65128.402766711246 67025.45550918682 54705.8910809474 61418.19826117223 69684.42258342388 65705.50887080647 0.7572869291158707 0.8509779724171603 0.8775822135063626 0.8484233122492238 0.9912167774968464 1.0200888275741946 0.8325921527906117 0.9347496019235743 1.0605567749340614 1.0 16.003726713375784 -2.7371359663140895 0.31120185718746834 0.9909833241432217 2.670005933613613e-10 0.565009462771779 0.061586597461947674 22.000630283184723 0.6208003983612759 0.06499705748909053 10.620367826817864 0.0018317408621392204 2.7371359663140895 -0.990983323876221 AATAARPPAPPPAPQPPS(ph)PTPS(ph)PPRPTLAR ddPTM_A459_Selumetinib_30min_R1 1 AATAARPPAPPPAPQPPSPTPSPPRPTLAR 30 2 Q96B36-3;Q96B36;H9KV91 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 2 AATAARPPAPPPAPQPPS(0.855)PT(0.416)PS(0.713)PPRPT(0.016)LAR 107.51 7.788300000000001e-10 33196000.0 2176.7 2693.1 2531.4 3077.0 2433.1 2346.0 2359.4 2293.1 1402.3 2148.7 True False 2227.4128748790977 2377.7906000117764 2187.6497839848785 2539.659712443564 2213.0265345986945 2322.401369997572 2181.4285584361633 2232.279538961449 2379.6006800602827 2424.5065751103893 0.9187077064444266 0.980731759782303 0.9023072184843521 1.0474954939348562 0.9127739876300125 0.9578861917055563 0.899741242539976 0.9207149866606618 0.9814783364536506 1.0 11.24347545090047 AATAARPPAPPPAPQPPS(ph)PTPSPPRPTLAR ddPTM_A459_Selumetinib_30min_R1 1 AATAARPPAPPPAPQPPSPTPSPPRPTLAR 30 2 Q96B36-3;Q96B36;H9KV91 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 AATAARPPAPPPAPQPPS(0.814)PT(0.155)PS(0.029)PPRPT(0.002)LAR 101.49 3.7193e-08 65293000.0 803.52 1114.2 1692.3 1534.3 1156.4 1365.2 981.74 847.81 697.96 903.84 True False 822.2404526222505 983.7489460224725 1462.4949551385046 1266.3633073780175 1051.8038241790018 1351.4673275024224 907.6865613965911 825.3233247250037 1184.3871430185225 1019.8566681471467 0.8062313835885183 0.9645952973075385 1.4340200940153025 1.2417071407482374 1.0313251430614225 1.3251541806926053 0.8900138516970784 0.809254231993632 1.1613270570366434 1.0 9.994150693051528 -7.289136500085755 24.852395858105734 0.9492532895583905 1.1400340075564221 0.15860724518018554 0.18860404870219596 1260.6229370464612 1131141.185406886 0.08243910252676469 0.05559509063980782 5.138821114760018e-08 7.289136500085755 0.19078071799803165 AATAARPPAPPPAPQPPS(ph)PTPSPPRPTLAR ddPTM_A459_Selumetinib_30min_R2 3 AATAARPPAPPPAPQPPSPTPSPPRPTLAR 30 2 Q96B36-3;Q96B36;H9KV91 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 AATAARPPAPPPAPQPPS(0.612)PT(0.286)PS(0.064)PPRPT(0.037)LAR;AATAARPPAPPPAPQPPS(0.592)PT(0.406)PS(0.002)PPRPTLAR;AATAARPPAPPPAPQPPS(0.87)PT(0.129)PSPPRPTLAR 104.33 2.3422e-09 75996000.0 52622.0 65681.4 57922.9 59191.5 64875.0 42493.0 49320.0 49290.0 43661.0 54304.0 True False 49697.47990255628 70718.95218101211 54196.203675685094 51129.515588967144 56724.8225101414 48346.025036951985 51613.47772572596 49433.42573960125 52394.41999026795 52736.1024212635 0.9423806011594434 1.340996943917073 1.027686939068005 0.9695353513336517 1.075635473721881 0.9167538520529456 0.9787124067954462 0.9373735158643314 0.9935209009519484 1.0 15.686503329111796 -5.505326720715571 24.594871352289008 0.9815496772997625 1.1523520873774933 0.2941191087001407 0.09762847686834605 603.5214152459243 845685.9258755229 0.02370902665872047 0.0476756042371954 3.123728494978822e-06 5.505326720715571 0.17080241007773078 AATAARPPAPPPAPQPPSPT(ph)PS(ph)PPRPTLAR ddPTM_A459_Selumetinib_30min_R1 2 AATAARPPAPPPAPQPPSPTPSPPRPTLAR 30 2 Q96B36-3;Q96B36;H9KV91 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 2 AATAARPPAPPPAPQPPS(0.023)PT(0.985)PS(0.987)PPRPT(0.005)LAR;AATAARPPAPPPAPQPPS(0.209)PT(0.764)PS(0.624)PPRPT(0.403)LAR 97.068 1.833e-06 50897000.0 3839.0 3629.5 3917.5 4688.5 3899.7 3508.7799999999997 3842.7 3357.4 2029.49 3289.8799999999997 True False 3928.4412306063546 3204.5564526912267 3385.5250172871743 3869.7414890450573 3546.972823547953 3473.4848589173375 3552.8420452244814 3268.350845627829 3443.8963019150956 3712.16814414491 1.0582605846673636 0.8632573548010416 0.912007453818346 1.0424477929828375 0.9554989660537024 0.9357024585203555 0.9570800425159273 0.8804425658312109 0.9277317643456018 1.0 11.858046344058078 -6.730082529299677 4.946186714451451 0.9335987735687207 0.9621120881432609 0.03833440317083414 0.05985023462391561 0.7259548455168434 43.089223503562145 0.020723748870180286 0.019999902870736885 1.8617333164947508e-07 6.730082529299677 0.028513314574540205 AATAARPPAPPPAPQPPSPT(ph)PSPPRPTLAR ddPTM_A459_Selumetinib_30min_R1 1 AATAARPPAPPPAPQPPSPTPSPPRPTLAR 30 2 Q96B36-3;Q96B36;H9KV91 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 AATAARPPAPPPAPQPPS(0.2)PT(0.548)PS(0.126)PPRPT(0.126)LAR 104.77 3.2764e-10 56918000.0 2574.3 2957.5 4441.6 4264.4 3597.9 3106.5 2859.0 3210.8 1994.4 2483.2 True False 2634.276181284172 2611.2345250955514 3838.4551159624057 3519.7025927020914 3272.4705802608373 3075.2514304763235 2643.3433282058963 3125.6391538517396 3384.351134787298 2801.9429084163066 0.9401605483721643 0.9319370916702417 1.3699262409782462 1.2561649925592064 1.167929071799139 1.0975425021113276 0.9433965696681333 1.1155256391781339 1.2078587056936774 1.0 11.452211844790634 -6.990575143469357 18.42439329654749 1.0683437585231363 1.1410933242056842 0.04727820653066528 0.13871542081124 31.3774823291751 61328.52311672525 0.053762364551511926 0.047213393942141774 1.0219387251386496e-07 6.990575143469357 0.07274956568254787 AATEALGEKS(ph)PDSATVSGYDIMK ddPTM_A459_Selumetinib_30min_R1 1 AATEALGEKSPDSATVSGYDIMK 23 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AATEALGEKS(0.991)PDS(0.008)AT(0.001)VSGYDIMK 113.8 6.5193e-06 114880000.0 3130.9 3779.3 4333.6 4229.3 3578.2 3203.3 3623.1 3358.1 1844.2 2842.8 True False 3203.8438783291053 3336.8177990510953 3745.1209227608692 3490.7321487934887 3254.5524417825204 3171.07771036369 3349.8066500254545 3269.0322793539053 3129.472704961258 3207.7010712169285 0.9987975210899687 1.0402521073402837 1.1675405031866188 1.0882348670567312 1.0146059029583507 0.9885826764900683 1.0443013783558748 1.019119988669552 0.9756123265482489 1.0 11.647323986564894 -6.290120615223084 7.680697397070292 1.0087980626553268 1.07802668591468 0.3599775022957168 0.04336595455212353 0.2829543484199624 65.25432851819076 0.01437293223561078 0.016568125588016507 5.127189684100544e-07 6.290120615223084 0.0692286232593533 AATEALGEKS(ph)PDSATVSGYDIMK ddPTM_A459_Selumetinib_30min_R2 5 AATEALGEKSPDSATVSGYDIMK 23 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AAT(0.011)EALGEKS(0.947)PDS(0.023)AT(0.01)VS(0.004)GY(0.005)DIMK;AAT(0.001)EALGEKS(0.979)PDS(0.012)AT(0.006)VS(0.002)GYDIMK;AAT(0.001)EALGEKS(0.996)PDS(0.003)ATVSGYDIMK;AAT(0.024)EALGEKS(0.955)PDS(0.019)AT(0.002)VSGYDIMK;AAT(0.003)EALGEKS(0.405)PDS(0.273)AT(0.007)VS(0.087)GY(0.225)DIMK 90.397 9.327e-05 59620200.0 159236.0 133236.0 162705.0 158053.0 147702.0 106626.0 137448.0 126569.0 98592.0 142411.0 True False 150386.30059221367 143454.77277873686 152236.73743980957 136525.90874336724 129146.35428736643 121312.76364554265 143839.60434804522 126937.29483537418 118313.15489064601 138299.22440178558 1.0873980041660452 1.037278216123421 1.1007779551787857 0.9871776890572681 0.9338183554245516 0.8771760230057832 1.040060817189862 0.9178453124697009 0.8554867563604244 1.0 17.0774335401455 -5.955556474917938 3.683071111630213 0.936424423937326 1.0709450667008469 0.5760833503981357 0.052652311917482306 0.16678192902558664 4.755350620237171 0.015509194055222416 0.023285767577036653 1.1077545054905064e-06 5.955556474917938 0.13452064276352094 AATEALGEKSPDS(ph)ATVSGYDIMK ddPTM_A459_Selumetinib_30min_R1 1 AATEALGEKSPDSATVSGYDIMK 23 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AATEALGEKS(0.229)PDS(0.766)AT(0.004)VS(0.001)GYDIMK 119.87 5.846e-06 141300000.0 2552.0 2815.9 3209.8 3175.4 2287.7 2553.2 3009.2 2337.4 1838.2 2311.0 True False 2611.456634672419 2486.2131189236065 2773.926790169337 2620.8759996403287 2080.7779389262405 2527.517126120119 2782.213621279181 2275.404559054769 3119.291143183918 2607.6393610462665 1.001463880965741 0.9534344189090856 1.0637693354407531 1.0050761001662252 0.7979546443459755 0.9692740353121531 1.0669472408036018 0.8725917368196979 1.1962126319232889 1.0 11.3485286419585 -8.260788540658535 24.997730355773648 1.0981063064307477 0.9682663332965565 0.26015543238993166 0.08885167140762305 79.35791397461851 3048379.6843206706 0.0683031995825872 0.02225127919340904 5.485439876916086e-09 8.260788540658535 -0.12983997313419116 AATEALGEKSPDSATVSGY(ph)DIMK ddPTM_A459_Selumetinib_30min_R1 2 AATEALGEKSPDSATVSGYDIMK 23 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AATEALGEKS(0.006)PDS(0.134)AT(0.033)VS(0.17)GY(0.657)DIMK;AATEALGEKS(0.006)PDS(0.031)AT(0.031)VS(0.204)GY(0.728)DIMK 73.722 0.001513 24660200.0 4522.1 4618.3 5747.3 5704.6 4656.7 4809.8 4329.0 4824.4 2949.7 4329.9 True False 4627.456131525138 4077.587289010581 4966.8482276591185 4708.398698604342 4235.502307207158 4761.417778948986 4002.460044702104 4696.441240140254 5005.425462435865 4885.684841797587 0.947145851884822 0.8345989193012124 1.0166124890347346 0.9637131438203828 0.8669209014408699 0.9745650677699301 0.8192219052814469 0.9612656960517935 1.0245084618667752 1.0 12.25434508812804 -8.000519264315797 24.999934193752434 1.0057985357058032 0.9180440342843565 0.2872133174003737 0.059639844325658754 22.734298311166945 1094515.0138965286 0.03248276879083413 0.015330561190866464 9.988050642321164e-09 8.000519264315797 -0.0877545014214467 AATEALGEKSPDSATVSGY(ph)DIMK ddPTM_A459_Selumetinib_30min_R2 1 AATEALGEKSPDSATVSGYDIMK 23 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AATEALGEKS(0.001)PDS(0.004)AT(0.018)VS(0.268)GY(0.709)DIMK 78.554 0.00090921 4172800.0 80787.0 69406.0 73714.0 76419.0 74415.0 54703.0 64003.0 66591.0 46520.0 70224.0 True False 76297.18195598459 74729.21702453558 68971.32149373494 66010.60036987213 65066.32242145933 62237.84170560757 66979.26631953863 66784.76878526651 55825.299877402394 68196.45065613584 1.1187852332769448 1.0957933485620774 1.0113623338186057 0.9679477411913219 0.9541013028601821 0.9126258200654295 0.9821517934601234 0.9792997750280671 0.8185953864210325 1.0 16.057409034428773 -5.381787905793606 1.275567366704535 0.9399456352009384 1.135891371357867 0.6532662396956305 0.04758314305254546 0.3719014257578329 0.9929990912022151 0.01495613091535154 0.07196418984649836 4.151567411393409e-06 5.381787905793606 0.19594573615692867 AATESVPCS(ph)PSPLAGEIR ddPTM_A459_Selumetinib_30min_R1 2 AATESVPCSPSPLAGEIR 18 0 Q8N9M1-2;Q8N9M1;J3QKZ5;J3QS16;J9JIE4 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 AATESVPCS(0.782)PS(0.218)PLAGEIR;AATES(0.001)VPCS(0.5)PS(0.5)PLAGEIR 145.04 9.9776e-05 5156100.0 3079.2 3829.3 2756.6 3683.8 3233.2 3720.7 3649.3 2995.0 1730.9 2683.0 True False 3150.939368919793 3380.9637758067274 2382.26886091993 3040.4934834902833 2940.757630867824 3683.2731361253045 3374.030362931716 2915.562870868928 2937.210880065851 3027.3891846331157 1.0408108032207462 1.1167919185839532 0.7869053879865244 1.0043285808523346 0.97138407106525 1.2166500279585541 1.1145016901223452 0.9630617978250655 0.9702125167702239 1.0 11.56385843675139 AATESVPCS(ph)PSPLAGEIR ddPTM_A459_Selumetinib_30min_R2 3 AATESVPCSPSPLAGEIR 18 0 Q8N9M1-2;Q8N9M1;J3QKZ5;J3QS16;J9JIE4 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 AATESVPCS(0.913)PS(0.087)PLAGEIR;AATES(0.021)VPCS(0.803)PS(0.176)PLAGEIR;AAT(0.008)ES(0.004)VPCS(0.894)PS(0.094)PLAGEIR 260.58 1.2443e-42 21707900.0 93043.0 87224.0 92297.0 92014.0 102629.0 81955.0 82349.0 80236.0 77421.0 106866.0 True False 87872.04254063978 93913.80033063529 86358.71150537553 79481.53446699637 89735.82750509898 93243.55733658234 86178.39167144775 80469.47347621522 92907.36332348152 103780.5009087868 0.846710526266114 0.9049272214746449 0.8321284899296895 0.7658619275392888 0.8646694390497136 0.8984689466717314 0.8303909782357899 0.7753814326540999 0.8952294748041183 1.0 16.663175878780116 -8.536001113556592 21.998106995137626 1.000000003091917 0.8413335798657844 0.5702727248728667 0.04258192751538008 306.0866002164992 513119.4819241191 0.04325995396881869 0.011169672098002112 2.9107096548263045e-09 8.536001113556592 -0.15866642322613256 AATESVPCSPS(ph)PLAGEIR ddPTM_A459_Selumetinib_30min_R1 2 AATESVPCSPSPLAGEIR 18 0 Q8N9M1-2;Q8N9M1;J3QKZ5;J3QS16;J9JIE4 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 AATESVPCS(0.019)PS(0.981)PLAGEIR;AATES(0.117)VPCS(0.244)PS(0.639)PLAGEIR 149.74 0.00016208 31414000.0 2942.3 4106.7 3263.1 3835.8999999999996 3220.6 3340.1 3571.3 3347.2 1758.0500000000002 2736.7 True False 3010.849865280822 3625.885654846964 2819.9889429252794 3166.032073760893 2929.2972986431128 3306.501626568153 3301.913965729873 3258.421382762095 2983.2824471083054 3087.9821027154103 0.9750217990684719 1.1741925743865385 0.9132141473376831 1.0252753961808425 0.9486121360830562 1.0707645046454732 1.069278854571839 1.0551943872656546 0.9660944746036457 1.0 11.592448675740053 AATESVPCSPS(ph)PLAGEIR ddPTM_A459_Selumetinib_30min_R2 1 AATESVPCSPSPLAGEIR 18 0 Q8N9M1-2;Q8N9M1;J3QKZ5;J3QS16;J9JIE4 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 AATESVPCS(0.003)PS(0.997)PLAGEIR 153.86 9.4977e-05 0.0 9376.7 8514.6 11139.0 12199.0 12935.0 10138.0 9777.7 10048.0 7697.2 9594.7 True False 8855.58055190414 9167.642441245845 10422.328867226197 10537.475155551225 11309.989659632816 11534.41747639891 10232.382424144993 10077.23801646406 9236.855077737344 9317.676080975563 0.9504065686491389 0.9838979549808509 1.1185545383473963 1.1309123717088851 1.213820867064168 1.2379071107600956 1.0981689356037003 1.0815183881568213 0.991326055710046 1.0 13.185754462233056 -5.215423405018901 3.76016238290217 1.1213650453168782 0.9580437855998506 0.3587972823036356 0.07492162047287985 0.24087558999878944 7.130260471738665 0.020994457443551356 0.06107825519166851 6.0894293340185555e-06 5.215423405018901 -0.1633212597170276 AATS(ph)PAPGPSDATAR ddPTM_A459_Selumetinib_30min_R1 1 AATSPAPGPSDATAR 15 0 Q8IXZ2;Q8IXZ2-2 Q8IXZ2 ZC3H3 Zinc finger CCCH domain-containing protein 3 1 AAT(0.038)S(0.961)PAPGPS(0.001)DATAR 100.73 0.0074021 7918600.0 1645.7 1773.6 2000.2 2079.2 2248.4 1706.7 1778.1 1865.8 1014.6 1595.6 True False 1684.0416080252346 1565.9460874757299 1728.58382631214 1716.1067514178283 2045.0326169872608 1689.5321475596138 1643.9764854434763 1816.3129230274612 1721.7020965479285 1800.4108024601564 0.9353651987224748 0.8697715462137617 0.9601052292899659 0.9531751026337258 1.1358699993317318 0.9384148024722838 0.9131118760213381 1.0088324956424253 0.956282918429129 1.0 10.81411041069067 -5.537806661871021 2.773654279489892 0.9880881729156531 0.9032746298259816 0.23505570018792932 0.05924457632977892 0.3935763315379379 6.0817226388322485 0.017218561962062475 0.037430206079137364 2.8986337070028004e-06 5.537806661871021 -0.08481354308967148 AATTATPAATTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AATTATPAATTSPK 14 0 Q92766;Q92766-2;A0A087X055;Q92766-5;Q92766-3 Q92766 RREB1 Ras-responsive element-binding protein 1 1 AATTAT(0.002)PAAT(0.04)T(0.199)S(0.758)PK 80.905 0.033010000000000005 7859500.0 3323.1 4096.0 3690.8 3848.2 2842.2 3159.2 3055.1 3073.2 2832.2 3760.0 True False 3400.5217643730102 3616.438415821261 3189.609632113213 3176.1841096604862 2585.1235118311674 3127.421316324094 2824.651347324878 2991.6887528395305 4806.036544296317 4242.632625501495 0.8015121893734686 0.8524043288791201 0.7517996285940949 0.7486351965921276 0.6093206129356054 0.7371416741402211 0.665777972466092 0.7051491413272913 1.1327958295065026 1.0 12.050744044055868 -8.257374101839591 24.99971857999596 1.0663979343135999 0.7326767144169952 0.7830633656145984 0.0699861693526458 148.62779898226557 914012.2003816749 0.05515930650019093 0.019136978735419717 5.528736579390716e-09 8.257374101839591 -0.33372121989660464 AATTATPAATTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 AATTATPAATTSPK 14 0 Q92766;Q92766-2;A0A087X055;Q92766-5;Q92766-3 Q92766 RREB1 Ras-responsive element-binding protein 1 1 AATTATPAAT(0.146)T(0.146)S(0.708)PK;AATTATPAATT(0.023)S(0.977)PK;AATTATPAAT(0.001)T(0.225)S(0.774)PK;AATTATPAATT(0.028)S(0.972)PK 246.77 6.828599999999998e-79 29329900.0 212077.0 188781.0 180991.0 146422.0 124859.0 133801.0 181424.0 188467.0 125499.0 122709.0 True False 200290.609351496 203259.8956734117 169346.2361081014 126479.07100796144 109173.09616637748 152230.8732254537 189860.5754848359 189015.40776760833 150602.30673504123 119166.072333729 1.6807687408759664 1.7056859531643775 1.421094383591338 1.0613681271104758 0.916142439104934 1.2774682444775514 1.5932435446317668 1.5861511927511018 1.2638018840905816 1.0 16.862614020278123 -5.403770368272304 3.7816848172162856 1.2678589525471302 1.6916901825265094 0.41129315377001974 0.21188918738882506 0.2687304696006179 6.721132262690392 0.06464635978312007 0.14563397637666886 3.9466592517938015e-06 5.403770368272304 0.42383122997937916 AAVEEGIVLGGGCALLR ddPTM_A459_Selumetinib_30min_R1 1 AAVEEGIVLGGGCALLR 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 170.4 1.2e-05 7533700.0 802.92 915.07 1093.5 1378.5 1442.1 1131.7 935.03 882.51 935.95 945.36 False True 821.6264737896466 807.9331789954987 945.0087061655457 1137.7708526498063 1311.6623096234346 1120.316125501386 864.4999343030277 859.1029680035191 1588.2387909166505 1066.7061645861954 0.7702462974969101 0.7574093089720899 0.8859128572976238 1.0666206781425875 1.2296378826424654 1.0502574773588071 0.8104386784324912 0.8053792098752787 1.4889187328665827 1.0 10.058947110051344 -5.5643676397139705 3.1182471054039245 1.0518066625653995 0.7680911234081323 0.30268210999422007 0.18585860366816914 0.3327919279286618 6.585472245701891 0.05352591445468501 0.10879043369289194 2.7266686213434715e-06 5.5643676397139705 -0.2837155391572671 AAVGQES(ph)PGGLEAGNAK ddPTM_A459_Selumetinib_30min_R1 2 AAVGQESPGGLEAGNAK 17 0 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 AAVGQES(1)PGGLEAGNAK;AAVGQES(1)PGGLEAGNAK 133.78 0.00060336 214530000.0 11002.7 14448.2 14575.8 15291.199999999999 12476.2 12961.9 12498.9 11275.8 6039.6 10136.7 True False 11259.041502472664 12756.598027214051 12596.486419138333 12620.878971373746 11347.729912852019 12831.515054463565 11556.097910077882 10976.729155039686 10248.760085068865 11437.844184819416 0.9843674490177036 1.115297412789109 1.1012990049170888 1.1034316229035959 0.9921213936375354 1.1218473382854666 1.010338812397481 0.9596851450038344 0.896039491311769 1.0 13.481527536826869 -7.595465516159918 3.0590688706112292 0.9447655305326527 1.0713323044386394 0.5149343682934207 0.05111151521573313 0.19344384019803787 3.6508989530914837 0.026554301471903994 0.014145543857734692 2.538250520069756e-08 7.595465516159918 0.1265667739059867 AAVGQES(ph)PGGLEAGNAK ddPTM_A459_Selumetinib_30min_R2 4 AAVGQESPGGLEAGNAK 17 0 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 AAVGQES(1)PGGLEAGNAK;AAVGQES(1)PGGLEAGNAK;AAVGQES(1)PGGLEAGNAK;AAVGQES(1)PGGLEAGNAK 196.65 8.578799999999999e-08 343440000.0 1816973.0 1460365.0 1949482.0 1880389.0 1981542.0 1494961.0 1620614.0 1705119.0 1417194.0 1691810.0 True False 1715992.9145792164 1572370.2996864237 1824054.450555517 1624276.7743480443 1732602.978749759 1700878.307845215 1695975.7621857175 1710080.6139923516 1700672.3997088422 1642963.0494497216 1.0444500959129632 0.9570332699892785 1.1102224430223482 0.9886264787829916 1.0545599180274081 1.0352504935609423 1.0322665276944307 1.0408515362321202 1.035125166252795 1.0 20.6478686034922 -5.222997957504813 24.999993570019427 1.0372237401186537 1.0007417323310221 0.1377907758448107 0.03639168350749219 1004.3401791340722 653159.532734901 0.008363326907218313 0.022125095422924367 5.984144094080216e-06 5.222997957504813 -0.036482007787631554 AAVGYS(ph)YS(ph)SKTLSVFQAMENRMLDRQK ddPTM_A459_Selumetinib_30min_R2 1 AAVGYSYSSKTLSVFQAMENRMLDRQK 27 3 Q03001-3 Q03001-3 DST Dystonin 2 AAVGY(0.079)S(0.851)Y(0.079)S(0.451)S(0.427)KT(0.103)LS(0.008)VFQAMENRMLDRQK 41.432 0.043427 78107000.0 28009.0 35096.0 21264.0 22352.0 17620.0 18396.0 25892.0 17183.0 11893.0 16868.0 True False 26452.37190891072 37787.750348573536 19895.89739049267 19307.61904064932 15406.418075201404 20929.88201773864 27096.029304024665 17232.999685201226 14271.93231818458 16380.977011672669 1.6148226012442013 2.3068068724867232 1.2145733051401855 1.1786610180144443 0.9405066660079665 1.277694364800374 1.6541155808177206 1.0520129338391373 0.8712503721856616 1.0 13.999733785848266 -5.317754596826094 8.769245721610865 1.1657631839538911 1.9596886698503992 0.6109537741894471 0.25898397970006903 0.23361644179562285 34.7978125494 0.06852700871442609 0.1434534485327282 4.811111291237783e-06 5.317754596826094 0.7939254858965081 AAVLS(ph)DSEDEEK ddPTM_A459_Selumetinib_30min_R1 1 AAVLSDSEDEEK 12 0 Q96ST2;Q96ST2-3;Q96ST2-2 Q96ST2 IWS1 Protein IWS1 homolog 1 AAVLS(0.999)DS(0.001)EDEEK 138.89 0.0012031 3431700.0 1825.9 2410.1 1884.1 1924.9 2426.3 1962.4 1877.2 2021.8 1084.4 2070.8 True False 1868.4399174170728 2127.924371574906 1628.2495686204902 1588.7523498481048 2206.841593398057 1942.6600377166378 1735.60129265761 1968.1752962680475 1840.1475985576342 2336.607351300132 0.799637952169173 0.9106897529834823 0.6968434673949399 0.6799398063025409 0.9444640290847878 0.8314020054057031 0.7427868835950932 0.842321794105851 0.7875296624115051 1.0 11.190199605464434 -11.221697429965655 2.485341835568727 1.0348634950644557 0.8045674614708039 0.34994676346149756 0.08015385953395882 15145761.742873503 11697101.500810338 3305084.5254259338 0.021966339777400447 6.002090922477007e-12 11.221697429965655 -0.2302960335936518 AAVLS(ph)DSEDEEK ddPTM_A459_Selumetinib_30min_R2 2 AAVLSDSEDEEK 12 0 Q96ST2;Q96ST2-3;Q96ST2-2 Q96ST2 IWS1 Protein IWS1 homolog 1 AAVLS(0.998)DS(0.002)EDEEK;AAVLS(1)DSEDEEK 210.93 5.4659000000000005e-06 9805700.0 72395.0 62244.0 66684.0 66730.0 63176.0 38102.0 58809.0 57794.0 45368.0 51489.0 True False 68371.5757201467 67017.91465399499 62393.624040049595 57641.25888432934 55239.26607939409 43350.20464448128 61543.735027822775 57962.17097168823 54442.867687833015 50002.37878551191 1.3673664609723974 1.34029452761582 1.2478131152057914 1.152770333819214 1.1047327631420518 0.8669628465164525 1.2308161436042508 1.1591882702285088 1.0888055530591623 1.0 15.609709110045358 -5.643793142800712 1.6221199343347843 1.0818546218752378 1.36297712588172 0.6042869082515506 0.09066060113561947 0.29122447076089414 1.5211288990048049 0.029719024912834624 0.07546532109766291 2.270946260341161e-06 5.643793142800712 0.2811225040064822 AAVPELSAQPAGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AAVPELSAQPAGSPR 15 0 A6NIX2 A6NIX2 WTIP Wilms tumor protein 1-interacting protein 1 AAVPELS(0.001)AQPAGS(0.999)PR;AAVPELS(0.002)AQPAGS(0.998)PR 112.57 0.0029751 16235600.0 4922.9 6015.9 5258.7 6537.7 5969.9 5303.299999999999 6213.8 5243.7 2701.3999999999996 4622.7 True False 5037.593991704095 5311.5556312839635 4544.59742397143 5396.013422828176 5429.92359907145 5249.953617011131 5745.088063240923 5104.620042061904 4584.078497550339 5216.068573911109 0.9657836971124807 1.0183063270775323 0.8712687265466303 1.0344981754682225 1.0409992740950467 1.0064962802194557 1.1014211147406647 0.9786336145182927 0.8788378512656533 1.0 12.348747120985522 -4.713893966274579 21.5405131151987 0.9945218962006107 0.965781737994444 0.012926166131152717 0.06689646302103379 14226.279577543064 6442550.3267654795 0.01712873470783155 7.813460292568079 1.932440067905595e-05 4.713893966274579 -0.02874015820616671 AAVPELSAQPAGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AAVPELSAQPAGSPR 15 0 A6NIX2 A6NIX2 WTIP Wilms tumor protein 1-interacting protein 1 AAVPELSAQPAGS(1)PR 105.63 0.0046841 7845000.0 22648.0 20015.0 28258.0 30697.0 28982.0 20026.0 22426.0 26591.0 20578.0 23721.0 True False 21389.314827127353 21550.086141631513 26439.91104498411 26516.01564472135 25341.02205763264 22784.39972207188 23468.853436275982 26668.375407622985 24694.174997359958 23036.113095440338 0.9285123205685709 0.9354914195961748 1.1477592133465218 1.1510629217204966 1.1000563312327427 0.9890730969966335 1.0187853019753275 1.1576768744420516 1.071976634905817 1.0 14.491609689602448 -5.243627825248709 23.719772329926506 1.0830651979634203 0.9320017794376821 0.5003966364316819 0.05888817127433996 356.83642081485306 475197.3034561859 0.01593562005420272 0.041919253243466584 5.7065309197627485e-06 5.243627825248709 -0.15106341852573812 AAVPS(ph)GASTGIYEALELR ddPTM_A459_Selumetinib_30min_R1 2 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 1 AAVPS(0.995)GAS(0.004)TGIYEALELR;AAVPS(1)GASTGIYEALELR 216.0 3.8054000000000005e-14 22547000.0 1630.25 3196.2000000000003 2758.44 2803.7 2606.17 2365.24 2756.59 2749.1800000000003 887.46 1834.1599999999999 True False 1668.231653085703 2821.987418126933 2383.8589990263263 2314.086426967183 2370.442383656684 2341.4478330660927 2548.658196956659 2676.262815804823 1505.9548024861272 2069.592302231335 0.8060677705880023 1.3635475040588436 1.1518495678864693 1.1181363713385704 1.1453668343765033 1.13135704580156 1.2314783903133086 1.2931352773777738 0.7276577134841867 1.0 11.015130877758853 -8.260835149957456 24.99998753530075 0.8638288523798625 1.1621517338885587 0.37081530781718075 0.1515511987600368 51.5806576521773 2134405.6396700107 0.11001598387674721 0.03585593026306867 5.484851200802395e-09 8.260835149957456 0.29832288150869624 AAVPS(ph)IK ddPTM_A459_Selumetinib_30min_R2 1 AAVPSIK 7 0 P00558-2;P00558 P00558-2 PGK1 Phosphoglycerate kinase 1 1 AAVPS(1)IK 86.13600000000002 0.035301 14634000.0 147820.0 128680.0 119870.0 113110.0 116170.0 95214.0 103990.0 109380.0 84043.0 130600.0 True False 139604.7561703446 138549.34222858553 112157.69470458804 97704.22287436663 101575.68602702308 108328.8642333643 108825.74105227596 109698.27769116628 100853.94835762071 126829.23866044916 1.100730065439393 1.0924085304928288 0.884320491782339 0.7703603988031746 0.8008854038694058 0.8541316290905554 0.8580493126165278 0.8649289300305084 0.7951947786080288 1.0 16.95252785089029 -5.299043392736889 3.9087275388415454 0.8412854365064507 1.1020550582938202 0.7293006753428983 0.05937285972308784 0.0958052280401748 3.1908623798425158 0.015021416873462522 0.03685851161263568 5.02292400234288e-06 5.299043392736889 0.2607696217873695 AAVPSGAS(ph)TGIYEALELR ddPTM_A459_Selumetinib_30min_R1 2 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 1 AAVPS(0.001)GAS(0.951)T(0.048)GIYEALELR;AAVPS(0.25)GAS(0.747)T(0.003)GIYEALELR 170.0 8.9086e-08 12030800.0 1361.45 2171.37 2397.64 2503.2 2186.02 1934.23 1988.1399999999999 1940.25 928.47 1290.79 True False 1393.169136079454 1917.1449909574735 2072.0536572937913 2066.0631108835655 1988.2948769731775 1914.7734023403254 1838.172999139303 1888.7882671797786 1575.5457772342365 1456.4754698593283 0.9565345691774756 1.3162906143161055 1.4226491967584718 1.4185361536388343 1.3651413416287843 1.3146623077182764 1.2620693153979727 1.2968212004025064 1.0817523602964687 1.0 10.508265688295985 -8.35257035935 2.625678982543937 0.9998848520537413 1.3078240620762491 0.40268897243330515 0.12435176383521326 0.2674099809314462 3.482515214925527 0.12122281108361531 0.033527625469089765 4.440477160821049e-09 8.35257035935 0.3079392100225078 AAVPSGAS(ph)TGIYEALELR ddPTM_A459_Selumetinib_30min_R2 2 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 1 AAVPS(0.021)GAS(0.493)T(0.138)GIY(0.348)EALELR;AAVPS(0.004)GAS(0.982)T(0.014)GIYEALELR 90.706 0.0056455 2628300.0 9154.6 8624.1 10041.4 10648.0 10817.9 8978.5 9085.1 7687.200000000001 6684.299999999999 8704.6 True False 8645.8239807674 9285.54073914786 9395.347256249677 9197.724031175454 9458.858688746954 10215.206876291939 9507.575151784127 7709.568479315533 8021.346774946697 8453.275580733103 1.0227779631925353 1.0984547528903086 1.1114445715769359 1.0880662700905095 1.1189578049845905 1.208431782299239 1.1247208328868405 0.9120214295257754 0.9489039719974506 1.0 13.045294767877234 -7.756290156922215 24.99988267454712 0.9478470108386724 1.1132275980737247 0.6979301315355824 0.04718998863616497 68.05170916955821 330401.31139365566 0.024327268887235638 0.013496028441568275 1.7527091063339573e-08 7.756290156922215 0.16538058723505233 AAVPSGAST(ph)GIYEALELR ddPTM_A459_Selumetinib_30min_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 1 AAVPS(0.013)GAS(0.303)T(0.684)GIYEALELR 166.36 3.4504e-07 4730900.0 1092.6 1632.2 1524.5 1530.7 1709.3 1438.3 1436.4 1410.6 859.16 1195.5 True False 1118.0554541704878 1441.1012652108068 1317.4812734790808 1263.3919797976482 1554.6941168014257 1423.8320078719116 1328.051191547725 1373.1863057254457 1457.9317694363485 1348.9540701561273 0.8288313730660115 1.0683101056539415 0.9766687410836724 0.9365715317879013 1.1525181999869618 1.0555081446969636 0.9845043807859352 1.017963721749632 1.0807868123097832 1.0 10.397625512202497 -4.75459879055823 24.914605065644707 1.029444679061684 0.8288310143663961 0.5149936156044471 0.05865330071289534 193.19919087224812 703599.5927689151 0.014932309785513298 0.14285413410235587 1.7595483673558717e-05 4.75459879055823 -0.20061366469528796 AAVPSGAST(ph)GIYEALELR ddPTM_A459_Selumetinib_30min_R2 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 1 AAVPS(0.007)GAS(0.407)T(0.586)GIYEALELR 130.64 0.0014289 0.0 3957.2 4263.0 5499.2 5337.6 7317.5 3631.9 2432.8 4615.5 4603.3 7442.3 True False 3737.274665926718 4589.958392294535 5145.387459076246 4610.60967212642 6398.210230719993 4132.16125789438 2545.9300205017485 4628.930340862842 5524.088626948543 7227.421461582384 0.5170965448455351 0.6350755129879476 0.7119257520025276 0.6379328639728955 0.885268731694963 0.5717338168057626 0.3522597974996657 0.6404677471029033 0.7643235774075211 1.0 12.819265311076103 -8.58477403889479 2.6691815770861314 0.9987078797643208 0.6224405337771967 0.4566219066145645 0.12831015841245214 0.3246580413460402 5.579317954281406 0.13261202871160624 0.035689270320605086 2.6015127643346625e-09 8.58477403889479 -0.3762673459871242 AAVPSGASTGIY(ph)EALELR ddPTM_A459_Selumetinib_30min_R1 2 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 1 AAVPSGAST(0.004)GIY(0.996)EALELR;AAVPSGAST(0.007)GIY(0.993)EALELR 206.45 2.766600000000001e-10 27356000.0 2769.58 3568.3 3263.6899999999996 3486.7999999999997 3499.3 2964.08 3283.7 3168.18 2100.39 2658.02 True False 2834.1058253354404 3150.5217771423363 2820.4988241659184 2877.895835342288 3182.788932851593 2934.2640463693087 3036.0078652779634 3084.149574701011 3564.208423583979 2999.202758307312 0.9449530604376182 1.0504530807114973 0.9404161877197492 0.9595536104956482 1.0612116583434636 0.9783480087306091 1.012271630141946 1.0283231322585344 1.18838528462662 1.0 11.550363342219363 -8.026296375336328 12.543237845677075 1.0989416531513336 0.9954272392002581 0.33142572713194407 0.057080010161380826 1.7083556973378735 810.4393368052841 0.03491497866138179 0.013678179136894167 9.41247042614869e-09 8.026296375336328 -0.10351441395107552 AAVPSGASTGIYEALELR ddPTM_A459_Selumetinib_30min_R2 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798;F5H1C3;E5RI09;P09104-2;K7EPM1;K7EKN2;E5RGZ4;F5H0C8;P09104;E5RG95;P13929-3;P13929-2;P13929 P06733;P13929-3 ENO1;ENO2;ENO3 Alpha-enolase;Enolase;Gamma-enolase;Beta-enolase 0 199.38 2.616e-09 5143200.0 7052.2 6323.8 6711.3 8042.8 7973.7 6819.3 6294.0 4402.3 4621.7 5936.3 False True 6660.266956193369 6808.815125778134 6279.502264710943 6947.356765396132 6971.972520217561 7758.596675558006 6586.683471324399 4415.109964160001 5546.169141087497 5764.903594640295 1.1553128073790349 1.1810804836542934 1.0892640547448316 1.2051123928343188 1.209382326306288 1.3458328570786984 1.142548763078731 0.7658601556259824 0.9620575695739028 1.0 12.493080766832753 -7.637842588603765 6.40947564551076 0.9002490615115162 1.19672547327631 0.7099911198886509 0.08261836091370615 0.11006861744514926 5.73318515385142 0.039851973609665775 0.022702153405396573 2.302276133400045e-08 7.637842588603765 0.2964764117647938 AAVQELSS(ph)SILAGEDPEER ddPTM_A459_Selumetinib_30min_R1 3 AAVQELSSSILAGEDPEER 19 0 E7ES96;P49768-7;P49768-2;P49768 E7ES96 PSEN1 Presenilin;Presenilin-1;Presenilin-1 NTF subunit;Presenilin-1 CTF subunit;Presenilin-1 CTF12 1 AAVQELS(0.002)S(0.737)S(0.261)ILAGEDPEER;AAVQELS(0.001)S(0.819)S(0.18)ILAGEDPEER;AAVQELS(0.003)S(0.907)S(0.089)ILAGEDPEER 260.44 2.5629e-47 10684500.0 2120.42 2413.94 2600.13 2024.95 2427.0 2444.12 2410.9 2804.41 1238.79 2030.3899999999999 True False 2169.821660380913 2131.314782589741 2247.0466274917426 1671.3304955192048 2207.4782785216516 2419.5343718834015 2229.0438719732733 2730.0279367924986 2102.1361523581804 2291.010334173399 0.9471025197988855 0.9302947048288734 0.9808103411731146 0.7295167859302669 0.9635392060848622 1.0560992832694378 0.9729523427826513 1.1916261991797161 0.9175585640108583 1.0 11.161768250955085 -6.5248206611699375 14.302463164670703 1.03328425823461 0.8979605459149429 0.3146229012643683 0.09079137780303051 0.36371375762925745 2606.6623796500708 0.02895013414478456 0.029574963789769284 2.9866156660955987e-07 6.5248206611699375 -0.1353237123196671 AAVVTS(ph)PPPTTAPHK ddPTM_A459_Selumetinib_30min_R1 3 AAVVTSPPPTTAPHK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;P35611-5;A0A0A0MSR2;D6RJE2;D6RAH3;D6RF25 P35611 ADD1 Alpha-adducin 1 AAVVT(0.151)S(0.849)PPPTTAPHK;AAVVT(0.184)S(0.816)PPPTTAPHK;AAVVT(0.038)S(0.962)PPPTTAPHK 128.64 0.00063005 482630000.0 24933.3 29000.5 27892.1 29794.3 27293.7 23675.9 28730.5 27538.8 15457.0 20511.0 True False 25514.19737824366 25605.107978033313 24104.506020338387 24591.284813278267 24824.989654094123 23437.74194199724 26563.335253941743 26808.3815653707 26229.40006538669 23143.78664405881 1.1024210415797864 1.1063491196072852 1.041510898413255 1.0625437052061246 1.0726416569549084 1.0127012620043268 1.1477523389959505 1.1583403346078036 1.1333236202348063 1.0 14.498337308198478 -7.28209124675749 24.96326865417738 1.1230491013070485 1.0671612870242682 0.14015185979574463 0.04853504013502932 1203.3067793898736 1454509.0902707889 0.019707051178361086 0.013306044907853042 5.2228644330072245e-08 7.28209124675749 -0.055887814282780335 AAVVTS(ph)PPPTTAPHK ddPTM_A459_Selumetinib_30min_R2 4 AAVVTSPPPTTAPHK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;P35611-5;A0A0A0MSR2;D6RJE2;D6RAH3;D6RF25 P35611 ADD1 Alpha-adducin 1 AAVVT(0.054)S(0.946)PPPTTAPHK;AAVVT(0.023)S(0.977)PPPTTAPHK;AAVVT(0.05)S(0.95)PPPTTAPHK;AAVVT(0.154)S(0.846)PPPTTAPHK 154.81 0.00011969 687760000.0 393801.0 362948.0 422880.0 407912.0 426254.0 306031.0 335309.0 370868.0 327173.0 400998.0 True False 371915.1169303066 390784.9445382396 395672.3611969302 352353.6819125502 372704.161760891 348183.9923771783 350901.5329021784 371947.16447949724 392616.74197741575 389420.14582207333 0.9550484763575513 1.0035046946872386 1.0160551924237466 0.9048162651388383 0.9570746808029292 0.8941088336407333 0.9010872618349485 0.9551307719181032 1.0082086049980654 1.0 18.57096799518171 -1.5374667112886051 19.605913645280474 0.9560245270156129 0.004058032835378422 0.0 0.04471226219131588 0.0 0.0 0.010883098436442274 0.0 0.02900903544691213 1.5374667112886051 -0.9519664941802345 AAWSLVLR ddPTM_A459_Selumetinib_30min_R1 1 AAWSLVLR 8 0 Q96KJ9 Q96KJ9 COX4I2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial 0 107.32 0.018761 1819700.0 964.45 975.16 972.08 1266.9 1051.7 1084.0 874.66 791.45 625.53 798.35 False True 986.9198085069811 860.9878138604155 840.0768752532275 1045.659697658353 956.5739206927165 1073.0959441932505 808.6836920071939 770.4581750080847 1061.478723096418 900.8259990875322 1.0955720744146542 0.9557759375645577 0.9325628657522775 1.1607787727236185 1.0618853381914517 1.1912355385837161 0.8977135349405198 0.855279683078086 1.1783393509641316 1.0 9.815104655973249 -10.004042337207357 7.096902314761515 1.0000000021958904 1.0306664987482992 0.006627939960697993 0.11548860810527428 0.0 0.0 0.11370155468891231 0.02757667763407815 9.907353583262348e-11 10.004042337207357 0.03066649655240883 AAYEAELGDAR ddPTM_A459_Selumetinib_30min_R1 4 AAYEAELGDAR 11 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;; 202.44 0.0002547 25694900.0 7699.6 8954.400000000001 8659.0 8990.9 9128.7 7717.2 9326.7 8136.4 4960.6900000000005 6800.3 False True 7878.985699186432 7906.014685212382 7483.155360482365 7420.808095095493 8303.010696802889 7639.571974656974 8623.17951003075 7920.596241248066 8417.928615537498 7673.184745531339 1.026820800030254 1.030343325151481 0.9752346136120804 0.967109269644156 1.0820814267033443 0.9956194498126817 1.1238071017451603 1.032243651615558 1.0970579876158824 1.0 12.905609775422596 -6.266548179938179 24.995256826964386 1.0572049527825171 1.000292997268746 0.29243806133044015 0.04203216359887943 534.3422549307865 2614314.165725408 0.012497435316293 0.01461900655082854 5.413171916843174e-07 6.266548179938179 -0.05691195551377115 AAYEAELGDAR ddPTM_A459_Selumetinib_30min_R2 4 AAYEAELGDAR 11 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;; 172.59 0.0033059 33515100.0 158627.0 136091.0 157487.0 159003.0 161525.0 119645.0 117203.0 135168.0 118396.0 133300.0 False True 149811.1463741934 146528.7420984651 147354.45787888044 137346.51710452602 141232.78544817874 136125.01272082733 122653.17173333876 135561.31650173306 142078.50826063918 129451.28264500611 1.1572781923298519 1.1319219022363065 1.1383004854650236 1.0609900056469197 1.091011093613348 1.0515539895739974 0.947485179190462 1.0471994848709416 1.0975442294400486 1.0 16.982049734432827 -5.9899870407747455 0.9474527762888401 1.027524147875475 1.154987997612151 0.5911570848589901 0.0394747864106311 0.4666522507348605 0.8462006208380846 0.018125804474898827 0.040614465540417255 1.0233235275115627e-06 5.9899870407747455 0.12746384973667602 AAYLQETGKPLDETLKK ddPTM_A459_Selumetinib_30min_R1 2 AAYLQETGKPLDETLKK 17 2 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 0 ; 115.09 0.001062 85558000.0 7458.700000000001 8263.3 9597.099999999999 9738.900000000001 7768.299999999999 6891.5 8171.7 7726.7 4422.7 6910.5 False True 7632.473197896229 7295.828994496053 8293.866533096809 8038.183936794485 7065.658636604761 6822.177766981358 7555.302089926586 7521.762816141216 7504.9988787724515 7797.529988970238 0.9788321697630551 0.935658984937044 1.063653047160915 1.0308628435112985 0.9061406171697033 0.8749152329816576 0.9689353039505729 0.9646340349804232 0.9624841314350085 1.0 12.928801480816237 -4.390073990368178 19.756281098076148 0.9660436677148594 6.358005948321361 0.0035084633673264642 0.052650891716838094 2791.761536731231 414023.01149278984 0.013885042751076038 2116.1716612382947 4.073108786970705e-05 4.390073990368178 5.391962280606502 AAYLQETGKPLDETLKK ddPTM_A459_Selumetinib_30min_R2 1 AAYLQETGKPLDETLKK 17 2 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 0 96.707 0.0037324 6678000.0 35854.0 39678.0 45215.0 45828.0 39769.0 28860.0 29610.0 27769.0 23694.0 43270.0 False True 33861.37821493393 42721.17501512143 42305.91612636976 39586.1473422905 34772.86268062907 32835.20303500418 30986.923671101926 27849.803192594576 28433.462065674383 42020.68267103844 0.805826465981523 1.0166701800055662 1.0067879300668265 0.9420634036860643 0.8275177952926328 0.7814057494509701 0.7374207580986964 0.6627641775984106 0.6766539774774134 1.0 15.358811979878386 -6.481256524742918 2.038112819327877 0.7455725045906283 0.9548809591455693 0.369271898312052 0.10296717118013542 0.2976092439665683 2.4696437798436355 0.03652510089711319 0.04064137037490023 3.301744592639658e-07 6.481256524742918 0.20930845455494096 ACANPAAGSVILLENLR ddPTM_A459_Selumetinib_30min_R1 1 ACANPAAGSVILLENLR 17 0 P00558-2;P00558 P00558-2 PGK1 Phosphoglycerate kinase 1 0 157.09 0.0023 0.0 994.07 1033.7 965.55 926.2 999.69 910.99 1038.3 769.08 608.39 813.09 False True 1017.2298968764939 912.6739234459072 834.4336133865048 764.4565569272766 909.2682160096044 901.8262677127399 959.9801950598745 748.6815000760855 1032.3933949524878 917.4580216672898 1.1087481637883434 0.9947854854299617 0.9095060413446434 0.8332332802955226 0.9910733728799906 0.9829618864456137 1.046347813620191 0.8160389711515215 1.1252758933605778 1.0 9.841498338664731 ACAS(ph)PSAQVEGS(ph)PVAGSDGSQPAVK ddPTM_A459_Selumetinib_30min_R2 2 ACASPSAQVEGSPVAGSDGSQPAVK 25 0 F8WDB4;Q9UFC0 F8WDB4 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 2 ACAS(0.711)PS(0.289)AQVEGS(1)PVAGSDGSQPAVK;ACAS(0.846)PS(0.154)AQVEGS(1)PVAGSDGSQPAVK 135.2 1.8239e-07 10491700.0 88340.0 78785.0 93617.0 101615.0 104262.0 70314.0 79032.0 77788.0 66744.0 87730.0 True False 83430.41645303908 84827.55616629726 87593.78414248266 87774.86170434774 91163.67544589387 79999.11525305912 82707.14459893705 78014.35020150339 80094.66498317609 85197.00695008546 0.9792646413261751 0.9956635708575461 1.0281321759789215 1.0302575741395772 1.07003378063861 0.9389897382184842 0.970775236827191 0.915693555375834 0.9401112533225646 1.0 16.37851512767525 -6.783377389576563 24.9988976147049 0.9489486101509343 1.0202282608283793 0.549265586815924 0.030481012566400838 181.50103907244957 206823.43763049922 0.011024311952812888 0.00973035739251462 1.6467308072863715e-07 6.783377389576563 0.0712796506774449 ACFHCETCK ddPTM_A459_Selumetinib_30min_R1 2 ACFHCETCK 9 0 Q14847;Q14847-2;F6S2S5;K7ESD6 Q14847 LASP1 LIM and SH3 domain protein 1 0 ; 113.66 0.012627 29641000.0 13188.400000000001 14002.8 13348.099999999999 11734.5 12940.1 11486.0 12365.6 12383.400000000001 7320.0 10746.3 False True 13495.6640598408 12363.345666274883 11535.501335864952 9685.289858845957 11769.670239760215 11370.461268453584 11432.852836398324 12054.952005047844 12421.50536835289 12125.692282826249 1.112980912352102 1.0195991600236487 0.951327236977868 0.7987411879619722 0.9706390336516891 0.9377164621402848 0.9428618646863404 0.9941660833766502 1.0243955626307295 1.0 13.565779495879257 -10.436905096048447 15.598432028876504 0.9999999998266621 0.9668334589619978 0.006712187864403751 0.07624705843638874 0.0 0.0 0.0784760281629242 0.019033232540863695 3.656746917341667e-11 10.436905096048447 -0.03316654086466431 ACFHCETCK ddPTM_A459_Selumetinib_30min_R2 3 ACFHCETCK 9 0 Q14847;Q14847-2;F6S2S5;K7ESD6 Q14847 LASP1 LIM and SH3 domain protein 1 0 ;; 172.25 0.00071352 21436900.0 332433.0 291320.0 301265.0 360879.0 339046.0 269517.0 315849.0 315938.0 265767.0 282079.0 False True 313957.7046947382 313663.30725856026 281881.9378925312 311726.657649001 296452.0103703028 306640.5203182682 330536.6043429205 316857.3272736483 318927.82615042134 273934.64634074026 1.14610440442139 1.145029704889547 1.0290116334605792 1.1379599543653642 1.0821997667339742 1.1193929808237764 1.2066257728194574 1.1566894933016891 1.1642478613446918 1.0 18.063472219278665 -7.014089402478795 24.592264668670264 1.14752840155296 1.106725517519013 0.007537084922404458 0.060212168430672106 1336.2020982063054 2332260.3053660584 0.02139868418869898 0.01726817831729645 9.680785501807329e-08 7.014089402478795 -0.04080288403394716 ACKVDS(ph)PTVTTTLK ddPTM_A459_Selumetinib_30min_R1 1 ACKVDSPTVTTTLK 14 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9 Q07866-6 KLC1 Kinesin light chain 1 1 ACKVDS(0.863)PT(0.103)VT(0.031)T(0.004)TLK 164.63 0.0012302 13038000.0 1721.1 1582.5 2591.5 3046.9 2334.7 1757.3 1497.4 1887.3 1245.5 1590.3 True False 1761.198281322374 1397.220164315709 2239.588534090546 2514.816112396585 2123.5267972247643 1739.6231575007382 1384.4499124363433 1837.242673185619 2113.52253227917 1794.4304958337837 0.981480355695823 0.7786426766373526 1.2480776153160056 1.401456405380624 1.1833987452593229 0.969456973418422 0.7715260722834837 1.023858364785504 1.1778235697544361 1.0 10.809310328597435 -6.775404714494562 24.00057207838022 0.9764611434966571 1.1226302218839974 0.11451874278903429 0.17911434482355287 349.65127151509927 600899.0113930417 0.07081577443057996 0.06280043650935108 1.6772402869068278e-07 6.775404714494562 0.14616907838734028 ACLISLGYDVENDR ddPTM_A459_Selumetinib_30min_R1 2 ACLISLGYDVENDR 14 0 O43707;O43707-2;F5GXS2;O43707-3 O43707 ACTN4 Alpha-actinin-4 0 ; 240.0 2.2369e-18 28251000.0 1824.9099999999999 2650.3 2213.9 1754.48 2080.31 1870.74 2344.2 2163.8199999999997 1633.52 2069.1 False True 1867.4268523432768 2340.001643908958 1913.264540082215 1448.0930036685038 1892.1463278085605 1851.9220540960166 2167.375106673753 2106.428464522072 2771.9641324196473 2334.6891397407303 0.7998610267021058 1.0022754653190435 0.819494341886854 0.6202508843765453 0.8104489354067435 0.7932199720180626 0.9283356271209804 0.9022308060918093 1.1872947388308308 1.0 11.189014754763999 -7.867363512461052 1.7307946606001448 1.0828412069764068 0.8121231433409526 0.50872301697841 0.10304369823495102 0.3249563892921731 1.8150026544310833 0.08715650752605918 0.03176717147808403 1.3571769889591034e-08 7.867363512461052 -0.27071806363545425 ACLISLGYDVENDRQGEAEFNR ddPTM_A459_Selumetinib_30min_R1 1 ACLISLGYDVENDRQGEAEFNR 22 1 O43707;O43707-2;F5GXS2;O43707-3 O43707 ACTN4 Alpha-actinin-4 0 156.0 1.8515e-08 7742400.0 1006.2 993.87 1663.5 1448.2 1412.6 1037.0 1209.4 1040.4 649.5 704.71 False True 1029.642502275623 877.5072383623718 1437.605836951427 1195.2990560808487 1284.8305794147868 1026.5687215206653 1118.1739843064736 1012.8052123045186 1102.1540623968851 795.1663929566911 1.2948767847784315 1.103551717143767 1.8079308301825157 1.5032062052274773 1.6158009075777997 1.2910112029553262 1.406213836765326 1.2737022355013956 1.386067208271608 1.0 9.63511297366274 -9.092852893608628 0.5969625423046468 0.9883037973285943 1.4463505159188197 0.3173880051530773 0.18484341672719407 2.5515388458494743 1.4991764136566472 0.2765837935525184 0.08274676435010338 8.075085072355581e-10 9.092852893608628 0.4580467185902254 ACPEEPAAPS(ph)PEPR ddPTM_A459_Selumetinib_30min_R1 3 ACPEEPAAPSPEPR 14 0 O94819 O94819 KBTBD11 Kelch repeat and BTB domain-containing protein 11 1 ACPEEPAAPS(1)PEPR;ACPEEPAAPS(1)PEPR;ACPEEPAAPS(1)PEPR 199.33 8.3176e-05 38067100.0 4749.6 5647.4 6073.299999999999 7430.6 6204.7 5323.599999999999 5705.9 5352.0 2830.56 4350.5 True False 4860.256438887195 4986.199782594965 5248.579218248935 6132.985199637033 5643.485980528759 5270.049417442059 5275.499369153552 5210.047574253926 4803.253584077183 4908.929052458581 0.9900848814372233 1.0157408529051124 1.0691902779935765 1.2493529920880393 1.1496369004767513 1.0735639812929492 1.0746741932461579 1.0613409806044218 0.9784728059313729 1.0 12.261192600600959 -8.05426872997704 1.9956692836827798 0.9875089842134944 1.0945267479891567 0.24593257005410796 0.06786829202595339 0.5458241645875503 3.908497263268959 0.06639716654074405 0.021428294880717503 8.825336428772145e-09 8.05426872997704 0.1070177637756623 ACPEEPAAPS(ph)PEPR ddPTM_A459_Selumetinib_30min_R2 4 ACPEEPAAPSPEPR 14 0 O94819 O94819 KBTBD11 Kelch repeat and BTB domain-containing protein 11 1 ACPEEPAAPS(1)PEPR;ACPEEPAAPS(1)PEPR;ACPEEPAAPS(1)PEPR;ACPEEPAAPS(1)PEPR 137.93 0.00058291 92045600.0 120503.0 109409.0 121731.0 115962.0 115498.0 84451.0 87604.0 95931.0 82219.0 104467.0 True False 113805.92567172935 117800.31849461714 113898.95999069161 100167.77555439214 100988.10867477924 96083.35868015038 91677.75958403283 96210.14332776802 98665.09739080288 101450.76627213696 1.1217847814618793 1.161157503518734 1.122701820557599 0.9873535630642428 0.995439584989268 0.9470934741134557 0.9036674926447722 0.9483431901311499 0.972541667414698 1.0 16.63042023645437 -5.798810100443609 2.446599294775655 0.9555364055207675 1.145443503632275 0.8895231007187322 0.02760531269778852 0.08622878745899157 1.0524543553696315 0.008684288826667422 0.015484021263652685 1.589241508254893e-06 5.798810100443609 0.18990709811150752 ACPGPPPPS(ph)PEPLAR ddPTM_A459_Selumetinib_30min_R1 2 ACPGPPPPSPEPLAR 15 0 A0A087WSV0;Q9HB09-3;Q9HB09 A0A087WSV0 BCL2L12 Bcl-2-like protein 12 1 ACPGPPPPS(1)PEPLAR;ACPGPPPPS(1)PEPLAR 170.42 5.267e-05 22108000.0 9232.2 8554.3 11989.8 11307.7 12275.3 10994.2 11176.8 10218.1 5497.9 8401.599999999999 True False 9447.29229726595 7552.758579213819 10361.65101525712 9333.022466817703 11165.001282380235 10883.608329934912 10333.724977506692 9947.082794933489 9329.5347492715 9480.027198514186 0.9965469612520346 0.7967022057064952 1.092998026090169 0.9844932162515817 1.1777393723227014 1.14805665659279 1.0900522499688932 1.049267326626711 0.9841253146123595 1.0 13.210675482931745 -5.278442549877535 24.861121955185574 1.0724930545902 0.8966245798152596 0.4358975664614645 0.07670195849198815 577.010468115048 843673.2549769473 0.020086542607587445 0.04198642400956863 5.266928832194974e-06 5.278442549877535 -0.1758684747749405 ACPGPPPPS(ph)PEPLAR ddPTM_A459_Selumetinib_30min_R2 3 ACPGPPPPSPEPLAR 15 0 A0A087WSV0;Q9HB09-3;Q9HB09 A0A087WSV0 BCL2L12 Bcl-2-like protein 12 1 ACPGPPPPS(1)PEPLAR;ACPGPPPPS(1)PEPLAR;ACPGPPPPS(1)PEPLAR 145.52 0.000328 36842000.0 182664.0 151996.0 213331.0 208568.0 203996.0 141479.0 201759.0 176114.0 156595.4 172761.0 True False 172512.26614192812 163653.604455829 199605.51571723065 180160.67860013188 178368.19873262133 160966.4480315092 211141.19327787377 176626.4625827579 187918.8556410525 167772.9410430157 1.028248447392344 0.975446954904781 1.1897360472810292 1.0738363259301753 1.0631523630910726 0.959430329055498 1.2584937235125346 1.0527708549704224 1.1200784493184248 1.0 17.356150526502056 -7.212249615737285 24.999996019282378 1.1122346325071484 1.0532602011817125 0.10285878161419959 0.08498074963235441 924.1433540319789 469682.8754191002 0.032076970053566446 0.024846744748895967 6.134093397679588e-08 7.212249615737285 -0.058974431325435894 ACQS(ph)IYPLHDVFVR ddPTM_A459_Selumetinib_30min_R2 1 ACQSIYPLHDVFVR 14 0 D6RAT0;P61247;D6RG13;D6R9B6;D6RB09;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 1 ACQS(0.999)IY(0.001)PLHDVFVR 76.155 0.028318 1961900.0 7050.0 5530.7 7821.1 6236.6 7788.4 7179.7 5389.2 6316.0 6060.3 8327.7 True False 6658.189223386078 5954.8869059965755 7317.898940969825 5387.164321264919 6809.951562820577 8168.638504172543 5639.80847849721 6334.378514329914 7272.529338929958 8087.257663036906 0.8232938161247867 0.7363295636311422 0.9048677865695486 0.6661299226172973 0.8420594281230459 1.01006284757163 0.6973697034872713 0.7832541979318172 0.8992577758674992 1.0 12.98143486165001 -8.528362829527643 3.5538060314183775 0.9994787057675009 0.8087690823128717 0.2918728348026167 0.09480499987265659 0.26453433157299805 9.18365191914859 0.09065867981352713 0.023906918252391038 2.9623554678027684e-09 8.528362829527643 -0.19070962345462916 ACS(ph)VEELYAIPPDADVAK ddPTM_A459_Selumetinib_30min_R2 1 ACSVEELYAIPPDADVAK 18 0 Q9H792;H0YN99 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 ACS(1)VEELYAIPPDADVAK 164.57 2.6947e-06 0.0 11793.0 15958.0 14333.0 16089.0 16639.0 14350.0 13828.0 15444.0 12475.0 16461.0 True False 11137.592271119425 17181.927286942577 13410.830384590452 13897.650444926934 14548.660065452676 16326.582243669798 14471.029399662188 15488.939483108157 14970.348580623271 15985.728159185683 0.6967209851319515 1.0748291923799254 0.8389252119794337 0.8693786298962615 0.9101030569628921 1.021322399648605 0.9052468086257852 0.9689229873590675 0.936482119021963 1.0 13.964496840760162 -6.534743819916456 23.606703662237038 0.9611954858283371 0.8832998737219151 0.19481522397885798 0.09087344417482104 222.88171550726534 443438.6306785219 0.028268144940941854 0.0282937820598709 2.919148443131822e-07 6.534743819916456 -0.07789561210642204 ACTGLSGPGSGSKS(ph)PPATR ddPTM_A459_Selumetinib_30min_R1 2 ACTGLSGPGSGSKSPPATR 19 1 I3L2J0;I3L2I4 I3L2J0 CIC 1 ACTGLSGPGS(0.002)GS(0.022)KS(0.935)PPAT(0.041)R;ACTGLS(0.003)GPGS(0.033)GS(0.077)KS(0.6)PPAT(0.287)R 87.05 0.0018924 55752000.0 4114.5 3584.6 5834.3 6513.700000000001 4985.5 4226.1 3942.0 3455.1 2626.8 2710.7 True False 4210.359844576676 3164.9133655646724 5042.0341055159115 5376.204572292377 4534.562405261516 4183.589270991786 3644.6517662775923 3363.459524253502 4457.487746118769 3058.6447494539652 1.376544250628752 1.0347436936341425 1.6484536513813919 1.757708074222136 1.4825397444639603 1.367791820785545 1.1915904149797854 1.0996568087398684 1.4573407869333395 1.0 11.578676837467501 -7.105399654322833 3.19567054037636 1.1952272079273405 1.4616896526169016 0.2781525849978447 0.20713263875349494 0.40111105082488835 7.7604271473707565 0.091545449183144 0.06971080695284025 7.845133632543124e-08 7.105399654322833 0.26646244468956115 ACTGLSGPGSGSKS(ph)PPATR ddPTM_A459_Selumetinib_30min_R2 1 ACTGLSGPGSGSKSPPATR 19 1 I3L2J0;I3L2I4 I3L2J0 CIC 1 ACTGLSGPGS(0.035)GS(0.035)KS(0.879)PPAT(0.051)R 61.985 0.01847 24266000.0 27196.0 27275.0 26537.0 33544.0 24809.0 17370.0 9449.9 14846.0 10349.0 23895.0 True False 25684.555194213845 29366.904797052182 24829.638311300976 28975.24933337242 21692.271624725967 19762.55983083933 9889.339074621608 14889.199402112388 12419.08917522005 23205.089263334048 1.1068500923544198 1.2655372476181037 1.0700083085021288 1.2486592490361887 0.9348066442908083 0.8516476539508858 0.42617112834155646 0.6416350841467586 0.5351881664529183 1.0 14.502153626702961 -6.721271145548067 1.930391599390659 0.6252240941132954 1.1698768371777564 0.6809378665064629 0.1561421182729186 0.17047951408280576 1.3091812121120017 0.0586256379349856 0.05530190097401082 1.8998917393287e-07 6.721271145548067 0.544652743064461 ACTLTVFPPEENPGS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 ACTLTVFPPEENPGSPSR 18 0 Q9P2J3 Q9P2J3 KLHL9 Kelch-like protein 9 1 ACTLTVFPPEENPGS(1)PSR;ACTLTVFPPEENPGS(0.986)PS(0.014)R 238.88 6.055899999999999e-25 21617500.0 2311.2 2831.8999999999996 2707.7 2299.3 2689.1000000000004 2262.3 2566.8 2703.1 1426.1100000000001 1826.87 True False 2365.046463187655 2500.3398314854057 2340.0092123314575 1897.770418206529 2445.871379799166 2239.543316004051 2373.184209457463 2631.4050070937583 2420.0045110466867 2061.3665597207223 1.1473197001449735 1.2129525530986378 1.1351737522357432 0.9206370450016625 1.1865290858946198 1.0864362310735596 1.1512674435637427 1.2765342460247662 1.1739806778346853 1.0 11.009385357646439 -7.51753842890611 24.99342135618645 1.1779346365305883 1.1150058796571964 0.007542667357643196 0.09805802685767331 698.7351231733493 3270227.838086437 0.04499755862130463 0.02693879024597347 3.037117338218443e-08 7.51753842890611 -0.06292875687339183 ACTLTVFPPEENPGS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 3 ACTLTVFPPEENPGSPSR 18 0 Q9P2J3 Q9P2J3 KLHL9 Kelch-like protein 9 1 ACTLTVFPPEENPGS(0.587)PS(0.413)R;ACTLTVFPPEENPGS(0.998)PS(0.002)R;ACTLTVFPPEENPGS(0.691)PS(0.309)R 189.77 2.224e-10 11248700.0 72915.2 57967.2 69001.4 72847.2 76506.0 65044.0 61364.7 67355.8 62988.6 68343.7 True False 68862.86508667233 62413.09784607457 64561.925047043864 62925.28569157068 66894.63230768204 74003.22058935586 64218.280141846255 67551.79422664696 75588.0800485328 66370.43980274204 1.0375532434520243 0.9403749324484064 0.9727512012716321 0.9480920403509361 1.0078979814884148 1.1150027152042237 0.9675735211746047 1.017799406293163 1.1388817110928644 1.0 16.018253213809302 -6.5242766020326135 24.973692712260085 1.045891429600938 0.9728393945876145 0.2961559033297909 0.05320404587150001 58.36128477842708 1042628.3806319551 0.017149640369531392 0.01727949287190396 2.9903594708721414e-07 6.5242766020326135 -0.07305203501332358 ADAASSLT(ph)VDVTPPTAK ddPTM_A459_Selumetinib_30min_R1 3 ADAASSLTVDVTPPTAK 17 0 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 ADAAS(0.058)S(0.024)LT(0.893)VDVT(0.024)PPT(0.001)AK;ADAAS(0.01)S(0.001)LT(0.986)VDVT(0.003)PPTAK;ADAAS(0.042)S(0.004)LT(0.788)VDVT(0.163)PPT(0.003)AK 254.68 1.0178e-30 96764000.0 27703.3 32788.6 34945.7 39354.4 33185.3 30275.6 30933.7 28395.0 16608.199999999997 25645.1 True False 28348.73298876192 28949.69546899341 30200.26588298977 32481.892813581067 30183.69547434059 29971.05495204538 28600.346104135264 27641.87236004114 28182.902385065354 28936.898389427763 0.9796742072094108 1.0004422408854408 1.0436593955772255 1.1225077538181663 1.0430867561593384 1.0357383347966362 0.9883694416463287 0.9552465502018085 0.9739434408548124 1.0 14.820622673983266 -7.313609979968786 3.3719674733826404 0.9732259111597594 1.0407671711945627 0.38221149345142913 0.03622661257049329 0.2773744288879636 6.379030032675468 0.018039387807428368 0.011956167135415925 4.857245113427653e-08 7.313609979968786 0.06754126003480332 ADAASSLTVDVT(ph)PPTAK ddPTM_A459_Selumetinib_30min_R1 1 ADAASSLTVDVTPPTAK 17 0 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 ADAASSLTVDVT(0.999)PPT(0.001)AK 199.65 1.3974e-07 19474000.0 3382.1 4048.6 3974.0 4395.6 3795.6 3819.0 4186.7 3322.5 1751.7 3118.5 True False 3460.896349578992 3574.5880298569214 3434.3526276194602 3627.9909756311126 3452.2886501676057 3780.5843273745604 3870.893848268492 3234.3765069990054 2972.5069608939566 3518.7898517623444 0.9835473260347284 1.01585720672311 0.9760039025630943 1.0310337157003213 0.981101115896014 1.0743990083639405 1.1000639456572834 0.9191729666320102 0.8447526240889923 1.0 11.780863641070395 -7.876095571450245 8.718653866469177 0.909259209794051 1.0215943037395885 0.4455015276125244 0.051618759975840166 0.2214404581746395 15.907591946408157 0.02833280292032579 0.013575803417862327 1.3301616685332997e-08 7.876095571450245 0.11233509394553753 ADAASSLTVDVT(ph)PPTAK ddPTM_A459_Selumetinib_30min_R2 3 ADAASSLTVDVTPPTAK 17 0 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 ADAAS(0.007)S(0.003)LT(0.016)VDVT(0.963)PPT(0.011)AK;ADAASSLT(0.017)VDVT(0.982)PPT(0.001)AK;ADAASSLTVDVT(0.999)PPT(0.001)AK 248.75 4.4905e-30 40336400.0 96104.0 98085.0 114302.0 122055.0 114225.0 87748.0 86448.0 96827.0 80351.0 106634.0 True False 90762.9244147936 105607.8041070159 106947.93376260764 105430.89844338088 99875.03431554374 99834.49050296437 90468.0032934622 97108.75053942729 96423.44519452208 103555.19935159502 0.8764690231210067 1.0198213587369167 1.0327625694533547 1.018113036366406 0.9644618033754517 0.9640702845252807 0.8736210625822987 0.9377486707327899 0.9311308924928153 1.0 16.66004046537283 -6.799851698892333 2.590342509695662 0.9301898593240564 0.9912049780336801 0.14378556683662758 0.050360422365037585 0.4281239813560647 5.878687544352745 0.019244066422707866 0.01742077846639402 1.5854344877361677e-07 6.799851698892333 0.06101511870962373 ADADPSPT(ph)SPPTAR ddPTM_A459_Selumetinib_30min_R2 2 ADADPSPTSPPTAR 14 0 Q9NWZ5;Q9NWZ5-3;Q9NWZ5-2 Q9NWZ5 UCKL1 Uridine-cytidine kinase-like 1 1 ADADPS(0.034)PT(0.483)S(0.483)PPT(0.001)AR;ADADPS(0.03)PT(0.484)S(0.484)PPT(0.002)AR 123.68 0.0037259 33038400.0 101291.0 105447.0 115063.0 121988.0 140671.0 100020.0 100023.0 103761.0 85180.0 106770.0 True False 95661.6517199999 113534.44583445531 107659.97185112227 105373.02395896244 122998.65136530391 113796.84710883978 104674.26769181446 104062.92733144184 102218.38012805511 103687.27267822463 0.9225978198584619 1.0949699312353376 1.0383142411820034 1.016258034734593 1.1862463751651446 1.0975006302074166 1.0095189601201373 1.0036229581848777 0.9858334344010766 1.0 16.661879292687438 -7.407513724352514 5.917938964951354 0.99803777729784 1.0636340551639716 0.17488510459032824 0.06335659309872081 0.41922650981962445 18.886499581479633 0.027822634066475723 0.01850542304669696 3.9127876193978425e-08 7.407513724352514 0.06559627786613154 ADADPSPTS(ph)PPTAR ddPTM_A459_Selumetinib_30min_R1 1 ADADPSPTSPPTAR 14 0 Q9NWZ5;Q9NWZ5-3;Q9NWZ5-2 Q9NWZ5 UCKL1 Uridine-cytidine kinase-like 1 1 ADADPS(0.001)PT(0.027)S(0.953)PPT(0.018)AR 132.31 0.00081845 16571000.0 4527.8 5316.5 5501.1 5927.5 5886.1 4427.2 5115.6 4903.4 2777.5 4126.3 True False 4633.28893043487 4694.041708426205 4754.080835379321 4892.373397955549 5353.70329427536 4382.666387575976 4729.726173406812 4773.345903512089 4713.214639426249 4655.950798565642 0.9951327088469764 1.0081811237937262 1.0210762615541191 1.050778586290633 1.1498625148540391 0.9413042742904721 1.0158453939985574 1.0252139917334635 1.0122990648608763 1.0 12.184860097409915 -10.106616251422349 15.130080021176411 1.0000153299168455 1.0256277619759882 0.020728103051526503 0.049704987977035445 0.0 0.0 0.04911498492618337 0.011912133567721958 7.82318766894194e-11 10.106616251422349 0.025612432059142654 ADAPDAGAQS(ph)DSELPSYHQNDVSLDR ddPTM_A459_Selumetinib_30min_R1 6 ADAPDAGAQSDSELPSYHQNDVSLDR 26 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 ADAPDAGAQS(0.991)DS(0.009)ELPSYHQNDVSLDR;ADAPDAGAQS(0.968)DS(0.032)ELPSYHQNDVSLDR;ADAPDAGAQS(0.997)DS(0.003)ELPSYHQNDVSLDR;ADAPDAGAQS(0.995)DS(0.005)ELPSYHQNDVSLDR;ADAPDAGAQS(0.593)DS(0.407)ELPSYHQNDVSLDR;ADAPDAGAQS(0.934)DS(0.066)ELPSYHQNDVSLDR 215.86 3.563599999999999e-35 325325000.0 14871.779999999999 18715.2 18308.190000000002 20740.5 22674.399999999998 16914.399999999998 19810.1 17828.96 7152.75 12450.07 True False 15218.263538553523 16524.015683539565 15822.038357689067 17118.561022403563 20623.504523490457 16744.256493046432 18315.808207796985 17356.078064176054 12137.694333809583 14048.157758451442 1.0832924715269616 1.176240754671098 1.1262714036771442 1.2185626981662383 1.4680575829299223 1.1919183127747126 1.3037871956398057 1.2354700425922076 0.8640061239707737 1.0 13.778093330849254 -8.25396940995338 24.718733110919693 0.9320030535564934 1.2298546550813505 0.5599899622677126 0.1039886793423139 330.36010933201254 1093198.5098798466 0.07697721271394047 0.027805545486183934 5.57224996352815e-09 8.25396940995338 0.2978516015248571 ADAPDAGAQS(ph)DSELPSYHQNDVSLDR ddPTM_A459_Selumetinib_30min_R2 2 ADAPDAGAQSDSELPSYHQNDVSLDR 26 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 ADAPDAGAQS(0.762)DS(0.238)ELPSYHQNDVSLDR;ADAPDAGAQS(0.875)DS(0.125)ELPSYHQNDVSLDR 133.15 3.4483e-09 70057000.0 36337.0 32887.0 60770.0 82850.0 88855.0 43025.0 37522.0 51812.0 48856.0 67059.0 True False 34317.53500853614 35409.327151628066 56860.124361373244 71565.68707577836 77692.24052622133 48951.30320793678 39266.847348432464 51962.76434206169 58628.56515069585 65122.832429793656 0.5269662532804069 0.5437313739355771 0.8731211810031742 1.0989338824126007 1.1930107709915452 0.751676507017861 0.6029659012568979 0.7979192919484988 0.9002766458891509 1.0 15.990875828593888 -5.267075923649474 5.461932071611796 0.8974657266999901 0.531064429941037 0.4569093372807598 0.1601524559338202 0.16077390298201844 17.90665948613322 0.04795364580686745 0.11465745713342183 5.406597961789176e-06 5.267075923649474 -0.36640129675895317 ADAPDAGAQSDSELPSYHQNDVS(ph)LDR ddPTM_A459_Selumetinib_30min_R2 1 ADAPDAGAQSDSELPSYHQNDVSLDR 26 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 ADAPDAGAQSDSELPSY(0.002)HQNDVS(0.997)LDR 124.48 5.0699e-09 3123700.0 11282.0 7051.4 15875.0 20276.0 21017.0 18754.0 17391.0 16926.0 17694.0 16273.0 True False 10654.991605424355 7592.219706175391 14853.619783393113 17514.37382194906 18376.656565636098 21337.1932681382 18199.715959612746 16975.251857749852 21233.29441166718 15803.156207668344 0.6742318727605889 0.4804242650269655 0.9399147605834285 1.1082832816301822 1.1628472391305595 1.350185557096785 1.151650703217215 1.0741684531038653 1.3436109934396465 1.0 13.947925101902058 -5.510713631411821 2.356644026783487 1.183916051683044 0.5716939457274773 0.8076984509193623 0.11426803871115404 0.11434133665358474 1.2506933931388045 0.03156609287578804 0.07597605568813273 3.0852216379367237e-06 5.510713631411821 -0.6122221059555667 ADDADEFGYSR ddPTM_A459_Selumetinib_30min_R1 1 ADDADEFGYSR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 153.1 0.007847100000000001 15639000.0 2239.0 2280.8 2506.4 2909.3 2477.9 1991.9 2128.6 1879.8 1254.9 1579.3 False True 2291.1643436644003 2013.7628756848467 2166.044646669708 2401.245369324686 2253.7743825087778 1971.8632945004945 1968.0379882543082 1829.941597549053 2129.4736457303334 1782.0185386847113 1.2857129675853338 1.1300459742529858 1.2155006245156363 1.347486188946732 1.2647311650148514 1.1065335470392499 1.104386932869338 1.0268925703206844 1.194978390798378 1.0 10.7992966302365 -6.807998320696354 5.749304761001412 1.087649035571932 1.2458173941786674 0.5684160983926387 0.07069832858619444 0.15568708931220102 11.830485542172827 0.025511517807780125 0.022829979995375504 1.5559716481305388e-07 6.807998320696354 0.1581683586067355 ADDADEFGYSR ddPTM_A459_Selumetinib_30min_R2 2 ADDADEFGYSR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 ; 210.08 0.00025982 35529000.0 76172.0 66176.0 84542.0 100278.0 99089.0 60002.0 62119.0 68456.0 57873.0 65746.0 False True 71938.66518067574 71251.48641062235 79102.65976236998 86619.96341080137 86640.55395310059 68266.73085607492 65007.656586463345 68655.19562649907 69449.21710672637 63847.74215137722 1.1267221479831766 1.1159593747526972 1.2389265007182984 1.3566644722601666 1.3569869667071965 1.069211354321985 1.01816688258664 1.075295590934505 1.0877317625746037 1.0 15.96234798233405 -6.871609025167965 8.049355049083923 1.050730167609005 1.2384073971548581 0.5940089877388488 0.07822776384832623 0.20311766657380675 13.70212924791998 0.03157403505198576 0.0278595227222603 1.343974333369401e-07 6.871609025167965 0.18767722954585309 ADDGRPFPQVIK ddPTM_A459_Selumetinib_30min_R2 2 ADDGRPFPQVIK 12 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 109.16 0.021862 78053000.0 444470.0 399480.0 440080.0 456740.0 458800.0 354570.0 353970.0 374570.0 336030.0 375110.0 False True 419768.1367543842 430118.83146934607 411765.7319228747 394531.22407955315 401161.44227595924 403408.79903400707 370430.306378249 375659.93668659875 403245.38946267177 364279.5996471743 1.1523240312138088 1.180738179919877 1.130356276666861 1.083045068847334 1.1012459733251796 1.107415291508862 1.0168845763996448 1.0312406652759225 1.1069667086854111 1.0 18.47468667810398 -1.5228788353239462 0.1625550593782038 0.9937475777521548 1.7303903152874331 0.6843798187661583 0.03148111633516574 35.43557919286984 0.37131171484517345 0.09253973489752819 6.2730406791174635 0.029999993780008515 1.5228788353239462 0.7366427375352783 ADDLLPLGDQTQDGDFGSR ddPTM_A459_Selumetinib_30min_R2 1 ADDLLPLGDQTQDGDFGSR 19 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 98.531 0.046389 0.0 6221.7 5121.1 5773.6 7512.5 6105.4 5941.8 5793.2 5332.9 4192.0 4912.0 False True 5875.92282143846 5513.87190306816 5402.132861820376 6489.284540214651 5338.385069031479 6760.2290157099105 6062.595279008021 5348.417856090877 5030.517134266352 4770.177797091306 1.231803733819188 1.1559049028382826 1.1324804004400872 1.3603863034563615 1.1191165814168702 1.4171859631379087 1.2709369622878182 1.1212198126770372 1.0545764431115736 1.0 12.219827324939311 -8.024955755976444 2.769454445190092 1.027383862570805 1.2397529595013415 0.47684518036362844 0.09076597913710177 0.2567570178286178 3.745425730866858 0.0718046111270902 0.02498322356331781 9.441570579807995e-09 8.024955755976444 0.21236909693053652 ADDTDSQSWR ddPTM_A459_Selumetinib_30min_R1 2 ADDTDSQSWR 10 0 O75369-8 O75369-8 FLNB Filamin-B 0 ; 148.94 0.010626 12074000.0 6291.700000000001 5965.9 7880.5 7527.1 5978.6 6550.7 6163.3 5498.799999999999 3441.3 4469.5 False True 6438.2843684829395 5267.409654528335 6810.371384487966 6212.63328616638 5437.836685607562 6484.805905559712 5698.397318898699 5352.953961380321 5839.6347573924595 5043.203861616735 1.276625840467011 1.0444570156320678 1.3504057284538797 1.231882243240263 1.078250420728445 1.2858504402161592 1.1299161158779578 1.0614193096815023 1.157921614439835 1.0 12.300124829251196 -8.274764371646976 0.5103605128858383 1.0019951046532827 1.2164221859524347 0.3172486179181273 0.09315235804912453 1.1158724280574635 0.737635063412234 0.10030977722147585 0.05344969849268525 5.311725560377005e-09 8.274764371646976 0.214427081299152 ADDTDSQSWRS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 2 ADDTDSQSWRSPLK 14 1 O75369-8 O75369-8 FLNB Filamin-B 1 ADDTDSQSWRS(1)PLK;ADDTDSQSWRS(1)PLK 112.84 0.001916 297480000.0 9546.6 8881.8 15758.300000000001 18049.4 11682.1 11537.8 9539.9 9300.2 6193.3 6433.299999999999 True False 9769.017205550053 7841.914726963205 13618.409414145883 14897.411119200142 10625.45611764227 11421.740207484223 8820.297662382449 9053.528484692897 10509.57775926502 7259.076720648607 1.3457658021111507 1.0802909279986947 1.876052552993139 2.0522459938774475 1.4637475985641426 1.5734425529619802 1.215071558245543 1.247201101889436 1.4477843620760047 1.0 12.825570348689313 -7.257516032749199 23.41012319414883 1.2481143371619345 1.5748624518964134 0.2709533451729139 0.2702899983094191 223.56841982340907 1334014.8722756626 0.1159561236027355 0.08626748359792918 5.5269300392768966e-08 7.257516032749199 0.32674811473447885 ADDTDSQSWRS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 4 ADDTDSQSWRSPLK 14 1 O75369-8 O75369-8 FLNB Filamin-B 1 ADDTDS(0.001)QS(0.002)WRS(0.997)PLK;ADDTDSQSWRS(0.999)PLK;ADDT(0.002)DS(0.001)QS(0.001)WRS(0.995)PLK;ADDTDSQSWRS(1)PLK 88.803 0.011178 326261700.0 475387.0 652582.0 525821.0 564356.0 534334.0 322475.0 241553.0 261396.0 181921.0 605365.0 True False 448966.89366494166 702632.9410181452 491990.2493306186 487489.7392315988 467206.1859134321 366893.0041134089 252785.69312818896 262156.61908356263 218310.28329744047 587886.5395228373 0.7636965017592496 1.1951846041388237 0.8368795953891823 0.8292241894622621 0.7947216928842148 0.6240881181106825 0.42999061236095737 0.4459306370517415 0.3713476472426699 1.0 19.16517822020853 -6.565773891133464 1.3701900710608812 0.5148449741576554 0.9448008230781104 0.3871887259212189 0.19592967426762262 0.3647375599286516 1.4195890570892102 0.08093507074273673 0.08686949775192308 2.717853910164928e-07 6.565773891133464 0.429955848920455 ADEASELACPT(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 ADEASELACPTPK 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 ADEASELACPT(1)PK;ADEASELACPT(1)PK;ADEASELACPT(1)PK;ADEAS(0.007)ELACPT(0.993)PK 141.85 0.0018864 343998000.0 15293.5 17903.0 15363.2 15283.499999999998 13969.2 14606.0 15962.900000000001 17765.800000000003 10241.3 15081.6 True False 15649.808794029257 15806.908437121105 13276.961824016942 12614.52363182685 12705.688326462572 14459.076901186923 14758.805601195489 17294.59327254866 17378.73810504268 17017.470267224293 0.9196319163942271 0.9288635848281906 0.7801959759899458 0.7412690272844177 0.7466261510639317 0.849660770616133 0.8672737703923596 1.0162846181584408 1.021229232791092 1.0 14.054728968618859 -7.675733556719078 3.0040354875749684 1.0180512158696255 0.8238666334915049 0.6539425391600164 0.0601216033244959 0.17912669168074882 3.228421281863493 0.03914824159133944 0.019539776835234442 2.109922207778397e-08 7.675733556719078 -0.19418458237812064 ADEASELACPT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ADEASELACPTPK 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 ADEASELACPT(1)PK;ADEASELACPT(1)PK 157.68 0.00085323 30724000.0 168978.0 116722.0 134736.0 142406.0 130898.0 114147.0 142495.0 131131.0 98561.0 151902.0 True False 159586.8792325295 125674.20207961617 126067.23244946479 123010.05713594801 114453.42299703266 129869.71312670202 149121.29984848594 131512.56950009425 118275.95402443384 147516.194571206 1.0818261662484587 0.8519349515822365 0.8545992717336007 0.8338749348402633 0.7758702244843094 0.8803759716294333 1.0108808750249123 0.89151275819153 0.8017828440344026 1.0 17.1705138190473 -9.50268491622587 15.096190261432325 1.0000024053674756 0.8837359700233449 0.12732767378702858 0.08841664404865558 0.0 0.0 0.08727868486818519 0.021168190386854434 3.1427879822696354e-10 9.50268491622587 -0.11626643534413073 ADEGIS(ph)FR ddPTM_A459_Selumetinib_30min_R1 2 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 ADEGIS(1)FR;ADEGIS(1)FR 144.77 0.0020674 22972000.0 6271.0 8256.2 9341.9 10022.2 11363.2 7814.4 10512.7 11678.3 3606.7 6628.6 True False 6417.102098758128 7289.56026579675 8073.321291383558 8272.010909994116 10335.400566335902 7735.794230907505 9719.718575176677 11368.553547535423 6120.306477054423 7479.445378031709 0.8579649659059149 0.9746124073861572 1.0794010629579773 1.1059658158999723 1.381840503400503 1.0342737783243572 1.2995239732246724 1.5199728018506062 0.8182834645775625 1.0 12.868715578835268 -5.256492369973896 1.2643718453571624 1.2002028058443504 0.8378547270893995 0.21191131462421364 0.19113348676577055 0.978780219439657 2.3168711465990475 0.058589085840233146 0.37019434743832375 5.539972769117936e-06 5.256492369973896 -0.3623480787549509 ADEGIS(ph)FR ddPTM_A459_Selumetinib_30min_R2 1 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 ADEGIS(1)FR 102.95 0.015806 7670400.0 12011.0 12286.0 14798.0 17475.0 20989.0 14116.0 15852.0 16575.0 13400.0 15661.0 True False 11343.476703842573 13228.29669428353 13845.912790844186 15094.874853943571 18352.174175959273 16060.350867710293 16589.1494101421 16623.230505861044 16080.374427282712 15208.826237835303 0.7458482677396351 0.8697776204040802 0.9103866777305556 0.9925075490961786 1.206679193316326 1.0559888459871174 1.0907580342310008 1.0929989103634505 1.0573054209324346 1.0 13.892621194926322 -5.554924127578254 1.4539349867618494 1.087540232992767 0.7823840496983121 0.7907667996289889 0.05706010116700923 0.19571064799313803 0.7824662261017612 0.017945165866975442 0.056379155976519386 2.7866079540608707e-06 5.554924127578254 -0.30515618329445493 ADEGISFR ddPTM_A459_Selumetinib_30min_R1 3 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 ;; 161.9 0.0053736 177493000.0 20028.3 20513.4 21340.5 23498.3 22812.2 19022.9 19933.2 19356.2 12233.099999999999 15925.4 False True 20494.92042171224 18111.68159157906 18442.577314975613 19394.763022721014 20748.840537821023 18831.546897411252 18429.62267568861 18842.8106982014 20758.677229726458 17969.580216532315 1.140534179137728 1.0079078850665644 1.0263221006135765 1.0793108569602259 1.154664732720453 1.0479681033442236 1.0256011800839426 1.0485949293832528 1.1552121407170173 1.0 14.133269086304878 -11.948995303786926 2.428691203631934 0.2195041807318644 1.0720211204179817 0.1534291579309185 0.052895127307500504 11967646.939159984 8673289.074021043 45743769.89625212 0.013950832885953253 1.1246171348700845e-12 11.948995303786926 0.8525169396861173 ADEGISFR ddPTM_A459_Selumetinib_30min_R2 2 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 ; 139.97 0.03284 145571000.0 197304.0 176011.0 185503.0 191845.0 197335.0 162614.0 150122.0 161911.0 149866.0 170048.0 False True 186338.63355049182 189510.47773543364 173567.93894039487 165715.38004891571 172544.01310271674 185012.60243708148 157102.97046109967 162382.13420419104 179843.38760590632 165138.27240223612 1.12837945341112 1.1475866555866154 1.051046110726084 1.0034946934970586 1.0448456956267658 1.120349630317292 0.9513419764888636 0.9833101184967479 1.089047287401991 1.0 17.33331499205964 -5.346213958124276 4.100886656455028 1.0282251613518754 1.1384344822659775 0.46031368960486674 0.04702455439652316 0.19476164512161043 5.971775122929115 0.012868233042601271 0.029382982839771886 4.505946613320957e-06 5.346213958124276 0.11020932091410218 ADEGLPANESFLNGNLAGASLS(ph)PLHTK ddPTM_A459_Selumetinib_30min_R1 1 ADEGLPANESFLNGNLAGASLSPLHTK 27 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 ADEGLPANESFLNGNLAGAS(0.077)LS(0.846)PLHT(0.077)K 106.61 1.3630999999999998e-09 15274000.0 1448.1 1679.7 1868.9 2443.6 1835.6 1591.5 1761.6 1753.4 949.1 1341.9 True False 1481.837912487904 1483.039943128655 1615.1136451328653 2016.8711320530028 1669.5703041015013 1575.4909549663835 1628.7210937277025 1706.894136154117 1610.5533804786517 1514.1459362128885 0.978662543053286 0.9794564101515641 1.0666829441635675 1.3320189843110548 1.1026482085850675 1.0405146011928865 1.075669824667881 1.1272982975625991 1.0636711706316058 1.0 10.564288546329262 -5.363992918414257 4.578033912926408 1.1128396311458661 0.9796759637050395 0.2540533075450213 0.08416019999844455 0.2839691938420469 9.657845199263994 0.023181753700761167 0.05097811022092958 4.325208836430404e-06 5.363992918414257 -0.13316366744082664 ADEGLPANESFLNGNLAGASLS(ph)PLHTK ddPTM_A459_Selumetinib_30min_R2 2 ADEGLPANESFLNGNLAGASLSPLHTK 27 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 ADEGLPANESFLNGNLAGAS(0.304)LS(0.665)PLHT(0.031)K;ADEGLPANES(0.002)FLNGNLAGAS(0.345)LS(0.55)PLHT(0.104)K 79.877 7.0344e-05 6006600.0 27764.0 23064.0 28464.8 28821.0 34027.0 20956.6 20947.7 22801.9 23074.1 26872.0 True False 26220.988028098003 24832.934637551283 26633.405758130917 24895.53008100187 29752.22405476038 23843.181424926173 21921.80955708008 22868.24975394226 27689.564744221192 26096.135538159117 1.004784328689446 0.9515943309398928 1.0205881142510995 0.9539929789450373 1.1401007636266733 0.9136671362723973 0.8400404544582809 0.8763079008577007 1.061059968198436 1.0 14.67154855980363 ADEHVIDQGDDGDNFYVIER ddPTM_A459_Selumetinib_30min_R1 2 ADEHVIDQGDDGDNFYVIER 20 0 P13861;P13861-2;H7C1L0 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 0 ; 164.5 2.0913e-07 7978500.0 3571.7000000000003 3239.3 3932.4 4197.1 3676.2000000000003 3478.5 3416.1 3070.3 1824.34 2959.4 False True 3654.9136606816155 2860.0412500902876 3398.4016791270165 3464.15527432463 3343.688359085824 3443.5094482253 3158.4208266821097 2988.865670260056 3095.771735478268 3339.2678169971086 1.0945254651567171 0.8564875316476492 1.0177086311642667 1.0373996529094898 1.0013238057954543 1.0312169124912933 0.9458423222616422 0.8950661744010227 0.9270809965348007 1.0 11.705316090180206 -7.406158735350517 5.761877565789467 0.9309876560899546 1.001077594291797 0.19905133972334577 0.06183789284724015 0.36179036407817916 15.743186422027016 0.02584745977559031 0.01717005531743021 3.925014492509376e-08 7.406158735350517 0.0700899382018425 ADEHVIDQGDDGDNFYVIER ddPTM_A459_Selumetinib_30min_R2 3 ADEHVIDQGDDGDNFYVIER 20 0 P13861;P13861-2;H7C1L0 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 0 ;; 175.16 1.2872999999999998e-10 6504200.0 56362.0 47233.0 60764.0 65573.0 63708.0 47587.0 48363.0 49990.0 45352.0 55283.0 False True 53229.62567496252 50855.61922196761 56854.510394840916 56641.84428026564 55704.431483253764 54141.677298224015 50611.97532946648 50135.46262371002 54423.66724075562 53686.83614751608 0.9914837508528669 0.9472642247390199 1.0590028110172292 1.055041577131311 1.0375808201882843 1.0084721168790458 0.9427259820340174 0.9338501990683917 1.0137246138180864 1.0 15.712280766590162 -7.11220165983941 5.94318189251192 0.9673586128790419 1.0188758317669755 0.24508086095690496 0.03755377301163282 0.3306932259174084 15.20915059328206 0.015569074004367514 0.01204550010239376 7.723218826979875e-08 7.11220165983941 0.05151721888793359 ADFDNTVAIHPTSSEELVTLR ddPTM_A459_Selumetinib_30min_R2 1 ADFDNTVAIHPTSSEELVTLR 21 0 P00390-5;P00390-4;P00390-2;P00390-3;P00390 P00390-5 GSR Glutathione reductase, mitochondrial 0 93.062 0.00076409 4190400.0 10192.0 9437.8 10150.0 12517.0 11026.0 10205.0 9230.6 9628.6 6783.3 9246.5 False True 9625.569441808633 10161.64891268997 9496.960050484424 10812.163006970626 9640.815306309345 11610.646118233473 9659.841190086907 9656.617631899466 8140.149541237818 8979.529519707814 1.071945854254716 1.1316460278222484 1.0576233453702646 1.2040901456185027 1.0736437009478252 1.293012745573253 1.0757625072545258 1.075403517601408 0.9065229445899401 1.0 13.132424141948578 -8.003557445607587 2.546717950812427 0.9557751248293492 1.1345738607880214 0.4774732378159696 0.07220491244564677 0.24351592635114913 2.986569525811726 0.0547336509524995 0.019084712723700815 9.918421362306256e-09 8.003557445607587 0.17879873595867213 ADFREPVAVSVAS(ph)PEPTDTALTLENVCDEPR ddPTM_A459_Selumetinib_30min_R1 1 ADFREPVAVSVASPEPTDTALTLENVCDEPR 31 1 Q86TB3 Q86TB3 ALPK2 Alpha-protein kinase 2 1 ADFREPVAVS(0.039)VAS(0.919)PEPT(0.034)DT(0.006)ALT(0.001)LENVCDEPR 71.098 8.6106e-05 6175800.0 690.98 661.35 613.95 655.63 821.24 577.05 473.92 529.89 285.1 370.29 True False 707.0784895869708 583.918834546726 530.5789621859506 541.1365281993412 746.9589870016986 571.2454009194795 438.1718328448192 515.8355958747037 483.79387711986465 417.8203284300396 1.6923027470774799 1.3975357224498908 1.2698734984475306 1.2951416945955272 1.78775166303755 1.367203465341035 1.0487087463916618 1.2345871198104617 1.157899327056969 1.0 8.706738876080529 -7.105668091396292 5.160814125571025 1.1330213352668246 1.4707446573467151 0.5445332115938648 0.16226437986584344 0.2055042127369969 8.185847190947742 0.06531063409151355 0.05051122269571503 7.840286059986204e-08 7.105668091396292 0.33772332207989053 ADFS(ph)PFGNSQGPSR ddPTM_A459_Selumetinib_30min_R1 1 ADFSPFGNSQGPSR 14 0 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 ADFS(0.997)PFGNS(0.003)QGPSR 95.751 0.012279 4113000.0 1371.5 1376.5 1309.4 1606.7 1401.1 1297.9 1310.5 1561.8 644.25 1044.8 True False 1403.4532815255568 1215.3387400825106 1131.590672019356 1326.120006494337 1274.3707523842963 1284.8443043989116 1211.6479299103967 1520.3759905586296 1093.245195841714 1178.9102572138195 1.1904665965350167 1.0309001322583997 0.9598615883567793 1.1248693430053158 1.080973504629677 1.0898576007264977 1.027769435795688 1.289645230631731 0.9273353838021884 1.0 10.203238184149937 -4.750527261506948 24.62132552008064 1.067706669047261 1.1904669157815566 0.1390713501399874 0.09594765841761282 832.7728948988661 1878861.133172004 0.022835845790658556 0.32678510125136373 1.7761217741805528e-05 4.750527261506948 0.12276024673429564 ADFTVVAGDEGSSTTGGS(ph)SEENKGPSGSAVSR ddPTM_A459_Selumetinib_30min_R1 2 ADFTVVAGDEGSSTTGGSSEENKGPSGSAVSR 32 1 P49916-4;P49916-3;P49916-2;P49916 P49916-4 LIG3 DNA ligase 3 1 ADFT(0.003)VVAGDEGS(0.059)S(0.059)T(0.059)T(0.059)GGS(0.546)S(0.211)EENKGPS(0.001)GS(0.001)AVSR;ADFTVVAGDEGS(0.013)S(0.019)T(0.182)T(0.182)GGS(0.331)S(0.273)EENKGPSGSAVSR 71.688 4.7779e-05 18448900.0 2440.2 2794.3 2563.2 2946.6 2613.3999999999996 2225.56 2498.08 2098.3999999999996 1123.27 1844.09 True False 2497.051912197351 2467.142056965175 2215.131518649773 2432.0316245324025 2377.0184314332437 2203.1728870468005 2309.6478143842546 2042.7436154361792 1906.1071496051568 2080.7969144577255 1.2000459510716381 1.1856717202063587 1.0645592096271714 1.1687981694101137 1.1423596483238327 1.0588120694233956 1.1099823333725818 0.9817121513603054 0.9160467013196747 1.0 11.022920449734292 -7.550474426146946 1.1181303056014422 0.9492762593584125 1.1491114471483197 0.7241087909882116 0.04750583659224888 0.27178592262937085 0.6292695250118308 0.03831279954902367 0.017343538916864704 2.8153057922726232e-08 7.550474426146946 0.19983518778990716 ADGATS(ph)DDLDLHDDR ddPTM_A459_Selumetinib_30min_R2 2 ADGATSDDLDLHDDR 15 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 ADGAT(0.196)S(0.804)DDLDLHDDR;ADGAT(0.016)S(0.984)DDLDLHDDR 308.2 2.0639999999999992e-94 38273000.0 132735.0 133279.0 153592.0 162370.0 202784.0 132177.0 134839.0 139827.0 130854.0 137805.0 True False 125358.12008030507 143501.07074046967 143710.05793832542 140254.92589612672 177308.46100803887 150383.18196665813 141109.28067840953 140233.87342039403 157028.45636624258 133826.21158961105 0.9367232217910041 1.072294201830411 1.0738558331085692 1.0480377814641413 1.3249157911737774 1.1237199363292176 1.0544218430925372 1.047880469413814 1.173375936604879 1.0 17.030001188523762 -4.107675141852773 1.1093972431651127 1.115561248248949 0.4254353065700289 0.25678476399182804 0.08622808491945785 9.029239197138958 3.1718471826513914 0.02722392112803994 10.480098575539118 7.80413652216135e-05 4.107675141852773 -0.69012594167892 ADGATSDDLDLHDDR ddPTM_A459_Selumetinib_30min_R1 1 ADGATSDDLDLHDDR 15 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 160.63 0.00017892 15789000.0 2508.3 3242.7 2302.3 2486.3 3084.4 2723.5 2476.0 2932.7 2029.3 2282.2 False True 2566.7385096978182 2863.0431765096673 1989.6603056286588 2052.114378631274 2805.416564595049 2696.104062740148 2289.2333265609623 2854.915269247848 3443.5738857921497 2575.1426005105086 0.9967364561438173 1.1117998575853951 0.7726408258844457 0.7968934917330222 1.0894218300916187 1.0469727238428115 0.8889734207756625 1.1086435635377536 1.3372361923217297 1.0 11.330436609522227 -7.935769470376617 5.595881279392304 1.186098124301807 0.959769580662566 0.31077068432840127 0.1316030649458881 0.2194894015469125 13.069599587112803 0.0767310818577805 0.03559087282345833 1.1593926147642651e-08 7.935769470376617 -0.22632854363924093 ADGATSDDLDLHDDR ddPTM_A459_Selumetinib_30min_R2 2 ADGATSDDLDLHDDR 15 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 ; 254.45 2.1898e-28 51678000.0 271350.0 217580.0 253020.0 302050.0 293730.0 191892.0 228820.0 227920.0 216780.0 243570.0 False True 256269.45330011504 234267.6863700319 236740.96866734631 260910.26893468646 256829.01142048254 218323.38117785976 239460.58339822834 228583.2094658127 260142.05733927927 236537.50122913928 1.0834199734437076 0.9904039957837022 1.0008601910358812 1.1030397614707899 1.0857855946135426 0.9229969034227893 1.0123577959262258 0.9663719633377665 1.0997920244675017 1.0 17.851709404505847 -6.724824980517367 24.999874563554055 0.9989550359726833 1.049157333061568 0.19308774392810857 0.05327625673201899 318.20583852624213 217266.42648087192 0.017851158924926766 0.017850674226748 1.8844083478752678e-07 6.724824980517367 0.050202297088884684 ADGGTGDSS(ph)PSPGSSLPSPLSDPR ddPTM_A459_Selumetinib_30min_R1 2 ADGGTGDSSPSPGSSLPSPLSDPR 24 0 Q8TD16;Q8TD16-2 Q8TD16 BICD2 Protein bicaudal D homolog 2 1 ADGGT(0.005)GDS(0.229)S(0.756)PS(0.008)PGS(0.001)SLPSPLSDPR;ADGGTGDS(0.12)S(0.868)PS(0.012)PGS(0.001)SLPSPLSDPR 181.6 2.0357e-20 11994900.0 3057.0299999999997 3588.29 3687.7 4203.8099999999995 4083.8 3248.4900000000002 3743.13 3400.08 2150.36 2768.4300000000003 True False 3128.252851055104 3168.171338649237 3186.930595086132 3469.6934987869286 3714.421011053449 3215.813139992928 3460.7826904887484 3309.898833383648 3649.003863919581 3123.7849572917853 1.0014302821174965 1.0142091667526094 1.020214463753962 1.1107337880886123 1.1890770529459638 1.0294604730989318 1.1078812203158597 1.05957960571435 1.1681354234713848 1.0 11.60907942580938 -5.7237033967428665 6.529557885789393 1.0992085505020603 1.0111998383936363 0.32781208218286306 0.054290758010215615 0.2064787388434574 23.981726270749757 0.014313996704619844 0.024515556507182283 1.889281201195082e-06 5.7237033967428665 -0.08800871210842409 ADGGTGDSS(ph)PSPGSSLPSPLSDPR ddPTM_A459_Selumetinib_30min_R2 3 ADGGTGDSSPSPGSSLPSPLSDPR 24 0 Q8TD16;Q8TD16-2 Q8TD16 BICD2 Protein bicaudal D homolog 2 1 ADGGT(0.008)GDS(0.125)S(0.812)PS(0.029)PGS(0.013)S(0.013)LPSPLSDPR;ADGGT(0.003)GDS(0.122)S(0.583)PS(0.223)PGS(0.052)S(0.016)LPSPLSDPR;ADGGTGDS(0.138)S(0.841)PS(0.014)PGS(0.006)S(0.001)LPSPLSDPR 140.8 3.9324e-08 13278000.0 42497.9 44195.7 42365.5 48822.0 44310.4 36737.3 40129.5 33915.9 35621.4 44471.0 True False 40136.03685057293 47585.36807842639 39639.74985406876 42172.35937735237 38743.73141199797 41797.529606994474 41995.60126509571 34014.58965392052 42746.67534507526 43187.006680465725 0.9293544502292906 1.1018445531662682 0.9178628689725455 0.976505727506873 0.8971154611074833 0.9678265019904763 0.9724128735250154 0.7876116514763211 0.989804078373655 1.0 15.398309705427526 -5.30645794037852 24.99490671495837 0.9331746182036805 1.0155997589323367 0.15621747451316936 0.0706330120291432 612.822325794327 340245.9500415212 0.01758315860854698 0.036602787657602 4.937897374246142e-06 5.30645794037852 0.08242514072865614 ADGGTGDSSPSPGSSLPS(ph)PLSDPR ddPTM_A459_Selumetinib_30min_R2 1 ADGGTGDSSPSPGSSLPSPLSDPR 24 0 Q8TD16;Q8TD16-2 Q8TD16 BICD2 Protein bicaudal D homolog 2 1 ADGGTGDSSPSPGSS(0.001)LPS(0.944)PLS(0.055)DPR 180.03 5.0221e-17 0.0 10478.0 8701.7 11854.0 12845.0 12447.0 8249.2 7166.2 8223.5 8475.9 10701.0 True False 9895.67470675735 9369.092409624523 11091.326545659344 11095.488841139062 10883.296582408168 9385.45242121818 7499.44249955591 8247.429023526285 10171.316836433252 10392.034325462972 0.9522365300998457 0.9015648059079255 1.0672911769048856 1.0676917044002114 1.0472729632677873 0.9031390897373747 0.7216529761820052 0.7936298866255772 0.9787608968449124 1.0 13.343190480757102 -6.924364438570801 5.419125297375166 0.8505127886677688 1.0069848894988593 0.3238602292562224 0.09048523520054566 0.2185911436754516 11.323893956570782 0.0336163235782383 0.02947547423759508 1.1902427956225882e-07 6.924364438570801 0.15647210083109053 ADGYEPPVQES(ph)V ddPTM_A459_Selumetinib_30min_R2 3 ADGYEPPVQESV 12 0 D6RAT0;P61247;D6R9B6;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 1 ADGYEPPVQES(1)V;ADGYEPPVQES(1)V;ADGYEPPVQES(1)V 128.54 0.0024364 17747500.0 105078.0 97072.0 111982.0 129565.0 122230.0 96512.0 100112.0 99701.0 86117.0 122786.0 True False 99238.18542056205 104517.11026432467 104777.20003678289 111918.02348790815 106874.37464993574 109805.65195129327 104767.40636816455 99991.11340361096 103342.80631002266 119240.84914365923 0.8322499054078495 0.876521016203133 0.8787022298922846 0.9385879444138421 0.896289949438178 0.9208727775747504 0.8786200963894736 0.8385642514432572 0.8666728478721004 1.0 16.863519028704296 -4.760604094336729 1.697687106092617 0.8976310485452537 0.8079278016514851 0.20348780392580734 0.04218665086171627 1.8123785770565155 4.9957313030876005 0.011640237018575323 0.27260603661768246 1.7353852653482885e-05 4.760604094336729 -0.08970324689376852 ADGYEPPVQESV ddPTM_A459_Selumetinib_30min_R2 1 ADGYEPPVQESV 12 0 D6RAT0;P61247;D6R9B6;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 0 125.71 0.039305 1461000.0 23215.0 19912.0 24587.0 24873.0 26308.0 21101.0 20412.0 20121.0 18691.0 24557.0 False True 21924.803237008196 21439.186372828706 23005.09918830152 21485.25449168173 23002.953843495947 24007.47121419347 21361.198445610687 20179.548778789132 22429.72227017472 23847.975603251478 0.9193569970785666 0.8989939745621699 0.964656269824637 0.9009257158394774 0.9645663106246922 1.0066880146808035 0.8957237629301441 0.8461744977648256 0.9405294035572818 1.0 14.541579184098595 -5.225471691672654 24.88171257405508 0.9347096647326907 0.9091754833379992 0.055656053906370406 0.04687521495745581 2188.071824648959 1513657.0356473823 0.012499491186054996 0.033066150928656675 5.950155399957786e-06 5.225471691672654 -0.025534181394691435 ADHGEPIGR ddPTM_A459_Selumetinib_30min_R1 4 ADHGEPIGR 9 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;;; 109.44 0.016059999999999998 44554600.0 23266.399999999998 26979.7 26397.6 29049.100000000002 28176.800000000003 24352.0 24318.8 23051.0 15333.099999999999 19675.8 False True 23808.461851466447 23820.90418147776 22812.95091163752 23976.22000414179 25628.21341501808 24107.04098984691 22484.41333682179 22439.612599799555 26019.150814684646 22201.380588521894 1.0723865462571915 1.07294697672059 1.0275464996727188 1.0799427498908554 1.1543522400705053 1.085835220639848 1.0127484300884526 1.010730504363356 1.171960937786749 1.0 14.438361772624106 -9.794234249450156 10.51655232701718 1.0 1.073807439350504 0.1658841493856501 0.0511406100363479 0.0 0.0 0.050634802569686194 0.012280743489830163 1.606074735889292e-10 9.794234249450156 0.07380743935050393 ADHGEPIGR ddPTM_A459_Selumetinib_30min_R2 2 ADHGEPIGR 9 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 109.44 0.016059999999999998 179553000.0 357940.0 309910.0 340060.0 382600.0 414860.0 289270.0 337690.0 352250.0 276890.0 365410.0 False True 338047.12774734956 333679.1004822895 318180.9098293328 330489.21997818694 362741.5779045432 329114.3167683879 353393.25412004057 353274.9891818735 332275.73695300845 354859.6638508011 0.9526220142323071 0.9403128461018413 0.8966387060635617 0.9313237136952803 1.0222113552388867 0.9274492152671437 0.9958676347859668 0.9955343623681223 0.9363581460549205 1.0 18.436889070053994 -6.0984206863496055 11.815538315862854 0.9775370627612325 0.9280904478795386 0.3895926368444407 0.03017486889303593 0.7293565630011105 84.599831451344 0.008644473334230476 0.011164024051706809 7.972220711164897e-07 6.0984206863496055 -0.049446614881693884 ADHGVPLPGS(ph)PPPTVALPLPSR ddPTM_A459_Selumetinib_30min_R2 1 ADHGVPLPGSPPPTVALPLPSR 22 0 A0A1W2PRX0;V9GYJ6;V9GY36;Q9UK80-2;Q9UK80-3;Q9UK80 A0A1W2PRX0 USP21 Ubiquitin carboxyl-terminal hydrolase 21 1 ADHGVPLPGS(1)PPPTVALPLPSR 106.36 4.114100000000001e-05 2690300.0 15306.0 15016.0 15102.0 16560.0 15734.0 11869.0 11858.0 13184.0 12924.0 12180.0 True False 14455.353794772665 16167.678915949973 14130.353761814358 14304.499432406614 13757.354256255327 13503.847013945424 12409.42049618123 13222.363257271307 15509.16112673147 11828.331752559472 1.2220957356598277 1.3668604545566228 1.194619330723182 1.2093420891167799 1.1630849171336815 1.141652711171497 1.0491268553992004 1.1178552930264394 1.3111875327114935 1.0 13.529958992362827 -5.857155495978419 1.2013307112450715 1.128667611299097 1.2927250117172675 0.3475825419794841 0.0847385116554161 0.56493162457297 1.632657372910589 0.03059571740553782 0.07095286248737774 1.3894550578714952e-06 5.857155495978419 0.16405740041817052 ADIKS(ph)PSLDVTVPEAELNLETPEISVGGK ddPTM_A459_Selumetinib_30min_R1 1 ADIKSPSLDVTVPEAELNLETPEISVGGK 29 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ADIKS(0.704)PS(0.275)LDVT(0.021)VPEAELNLETPEISVGGK 85.76 2.357e-06 15959000.0 1368.8 1398.4 2183.5 2040.6 1686.0 1307.0 1278.3 1340.2 909.78 1073.5 True False 1400.6903767788438 1234.674677901477 1886.992693106969 1684.2475168060894 1533.501597687477 1293.8527666610505 1181.8768018347653 1304.6535424168749 1543.8302122978264 1211.2941817754934 1.1563585443180588 1.0193020791131953 1.5578318805602194 1.390452907432734 1.2660026117187302 1.0681573362835313 0.9757140912725193 1.0770740601631035 1.274529536693479 1.0 10.242333573349642 -6.737254942524185 6.2124704005473195 1.0770580796525937 1.2866342966453475 0.30183099188433704 0.15109096071561728 0.23239147815997108 29.15476047370761 0.0549734446411337 0.05328851204018812 1.8312391202435785e-07 6.737254942524185 0.20957621699275375 ADIKS(ph)PSLDVTVPEAELNLETPEISVGGK ddPTM_A459_Selumetinib_30min_R2 1 ADIKSPSLDVTVPEAELNLETPEISVGGK 29 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ADIKS(0.769)PS(0.229)LDVT(0.002)VPEAELNLETPEISVGGK 114.26 3.9696e-12 5494000.0 65850.0 67998.0 64199.0 68250.0 57015.0 47471.0 65045.0 60477.0 54119.0 71946.0 True False 62190.32061843591 73213.22795196911 60068.50623458613 58954.23226218304 49852.26597943289 54009.69935116718 68069.72138422231 60652.9780574937 64944.312211202465 69868.73204184262 0.8901023218968922 1.0478682783039994 0.8597337389579736 0.8437856325613128 0.7135132486671952 0.7730167382860496 0.9742515628229388 0.8680990234826383 0.9295189752736454 1.0 16.09235933843189 -10.042999989357494 21.54633620529256 0.9999999999999958 0.8758804936417011 0.14264381284300032 0.08979500872237073 0.0 0.0 0.09470876063772954 0.02297024845768819 9.05732623093428e-11 10.042999989357494 -0.12411950635829472 ADIPVKS(ph)SPQAAVPYK ddPTM_A459_Selumetinib_30min_R2 1 ADIPVKSSPQAAVPYK 16 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 ADIPVKS(0.674)S(0.326)PQAAVPYK 70.555 0.023247 14034000.0 116620.0 102470.0 112390.0 120870.0 110140.0 105160.0 109970.0 97947.0 99434.0 113630.0 True False 110138.72726684877 110329.11950701887 105158.94976097945 104407.29748761986 96303.22853590695 119644.83545256566 115083.82290142089 98232.00955400127 119323.57841809148 110349.20665380395 0.998092606251212 0.9998179674562764 0.9529651635003795 0.9461535850925915 0.8727133747144814 1.084238292966842 1.0429057570161855 0.8901922590361915 1.0813270166267948 1.0 16.75171673195885 -6.769553428955325 24.999326345490207 1.0143179760262475 0.9560091526516712 0.2256842943462346 0.060451101148678875 334.7411206699414 1031328.8183843577 0.021604837195824324 0.01938163749491866 1.6999907998916114e-07 6.769553428955325 -0.058308823374576324 ADIPVKS(ph)SPQAAVPYKK ddPTM_A459_Selumetinib_30min_R2 1 ADIPVKSSPQAAVPYKK 17 2 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 ADIPVKS(0.591)S(0.408)PQAAVPY(0.002)KK 53.981 0.03284 13315000.0 97027.0 107490.0 113750.0 126850.0 111500.0 69937.0 69103.0 79490.0 48688.0 100260.0 True False 91634.62776985552 115734.13736517445 106431.44884163569 109572.8111715446 97492.3731773528 79570.18692512429 72316.42642499681 79721.30273972201 58426.96045638361 97365.23329323604 0.9411432055411239 1.18865978594861 1.093115532534029 1.1253792289650542 1.0013058037229146 0.8172340807265547 0.7427335608306977 0.818786131797419 0.6000803210774264 1.0 16.571119093238842 -6.692142859157744 2.642346397094859 0.7746437924707231 1.0938784706448825 0.620083615723966 0.10864846475628617 0.1641450640004625 2.3367731005900563 0.037622734958829444 0.03633880522091976 2.0316885864569422e-07 6.692142859157744 0.3192346781741594 ADLEEEPLLHNSK ddPTM_A459_Selumetinib_30min_R1 1 ADLEEEPLLHNSK 13 0 B8ZZB0;F5GZA4;E7ESC5;Q96AQ1-2;Q96LY2-2;Q96AQ1;Q96LY2;C9IYK9 B8ZZB0 CCDC74B;CCDC74A Coiled-coil domain-containing protein 74A;Coiled-coil domain-containing protein 74B 0 74.611 0.027528 15445000.0 4440.2 5227.3 6320.6 6419.5 5403.2 4338.9 4483.4 4543.3 2802.0 3891.8 False True 4543.648020874794 4615.285285894157 5462.297236570602 5298.454833939372 4914.481514012442 4295.254605405996 4145.213528393952 4422.796925281736 4754.789350017047 4391.350439342215 1.0346812634601286 1.0509945288232303 1.2438764138780063 1.2065661593459693 1.1191276082144306 0.9781170199774323 0.9439496085889396 1.0071610057939786 1.082762447610369 1.0 12.100448953931263 -6.706436978127675 5.881247643113136 0.9992311718843865 1.138471804690238 0.47869488565998064 0.06701171735330577 0.18585589663315394 13.457450331216924 0.024819609090172518 0.024496082421853964 1.9659072390195265e-07 6.706436978127675 0.13924063280585153 ADLGPGS(ph)PPWAVK ddPTM_A459_Selumetinib_30min_R2 1 ADLGPGSPPWAVK 13 0 A0A087WVC5;A0A0C4DH65;A5PL33-3;A5PL33-2;A5PL33 A0A087WVC5 KRBA1 Protein KRBA1 1 ADLGPGS(1)PPWAVK 87.49799999999998 0.035920999999999995 0.0 14603.0 15997.0 16514.0 15240.0 15566.0 14238.0 15374.0 15855.0 10498.0 14436.0 True False 13791.423720440695 17223.918461537804 15451.507219083705 13164.285709533628 13610.459918194385 16199.155260304562 16088.921463003066 15901.135425063456 12597.893338627895 14019.195170767527 0.9837528868417657 1.2285953830967904 1.1021679226852337 0.939018649015135 0.9708445993087088 1.155498233884541 1.1476351721353648 1.134240249270522 0.8986174445232565 1.0 13.775115907466365 -8.261245915529063 24.999875669584924 0.9493087185405568 1.0843006420887364 0.25776547771541813 0.09052222796855688 24.98053860681167 3229180.0658882097 0.07520716105787088 0.024251630840362637 5.479665956677153e-09 8.261245915529063 0.13499192354817968 ADLINNLGT(ph)IAK ddPTM_A459_Selumetinib_30min_R1 2 ADLINNLGTIAK 12 0 P07900;P07900-2;Q14568;P08238;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 ADLINNLGT(1)IAK;ADLINNLGT(1)IAK 126.48 0.0063803 35484000.0 3473.5 4156.0 4197.7 4541.8 4390.6 3877.4 3551.6 4379.5 2360.8 3726.0 True False 3554.425791745553 3669.413587928018 3627.6753963156057 3748.659890145005 3993.47100522339 3838.3968763975213 3283.6999525904366 4263.341433379124 4006.1051739900972 4204.268394313452 0.8454326551923151 0.8727829062700041 0.8628553308400277 0.8916319175091946 0.9498611008338148 0.9129761747820868 0.7810395637518899 1.0140507297644397 0.9528661822372275 1.0 12.037639056432507 -7.788385788347054 24.99999553582364 0.9875939079799213 0.8784555903508372 0.5883575012858588 0.044022609150906736 172.65345647421643 160179.76401223315 0.024617593030124712 0.011830687597457945 1.6278493545160563e-08 7.788385788347054 -0.1091383176290841 ADLINNLGT(ph)IAK ddPTM_A459_Selumetinib_30min_R2 1 ADLINNLGTIAK 12 0 P07900;P07900-2;Q14568;P08238;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 ADLINNLGT(1)IAK 128.96 0.0055582 7552300.0 59203.0 51902.0 63535.0 58529.0 65204.0 52577.0 53455.0 49790.0 35139.0 51085.0 True False 55912.73426838665 55882.71650876635 59447.2272716776 50557.2492318434 57012.490588844055 59819.004503514036 55940.76341907302 49934.88065682177 42167.78186569306 49610.043315229945 1.1270446573309445 1.1264395830835878 1.1982901706805749 1.0190930274056558 1.1492126750742346 1.2057841619571819 1.127609646772866 1.006547814109489 0.8499847822698401 1.0 15.59834459641802 -7.895892354282708 3.3718573414909057 0.9245772878389186 1.1373235453570245 0.6849437687574979 0.05877389689125476 0.13216868934448803 2.8962959618337525 0.03709575020831005 0.01571637118924529 1.2708890730895513e-08 7.895892354282708 0.21274625751810594 ADLLLSTQPGREEGSPLELER ddPTM_A459_Selumetinib_30min_R2 1 ADLLLSTQPGREEGSPLELER 21 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 107.15 0.00037722 3770000.0 7751.5 4260.9 9007.1 8050.0 6107.2 5124.6 7104.3 7650.6 1649.8 5923.7 False True 7320.7026617130705 4587.697329047101 8427.592992188987 6953.576112975434 5339.958936939272 5830.467133512905 7434.66402690339 7672.861979374986 1979.8060992635076 5752.667389379028 1.272575340481019 0.797490454170395 1.4649887472633292 1.2087568500507446 0.9282578976838246 1.0135241165302755 1.292385518521335 1.3337920411566213 0.34415445310096715 1.0 12.490015342826977 -8.250365068763358 24.999442314808636 0.6720771943256232 1.1546905521626392 0.40069227617877234 0.2404164426767526 624.5721245683852 1409933.5400454411 0.16036118882335973 0.059355234261405446 5.618688186309819e-09 8.250365068763358 0.482613357837016 ADLNQGIGEPQS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 6 ADLNQGIGEPQSPSR 15 0 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 ADLNQGIGEPQS(0.988)PS(0.012)R;ADLNQGIGEPQS(0.998)PS(0.002)R;ADLNQGIGEPQS(0.986)PS(0.014)R;ADLNQGIGEPQS(0.985)PS(0.015)R;ADLNQGIGEPQS(0.999)PS(0.001)R;ADLNQGIGEPQS(0.997)PS(0.003)R 234.82 1.6062e-14 410146100.0 16631.03 20780.12 16984.32 16773.899999999998 18177.58 15333.03 18590.24 17394.34 9146.11 15943.599999999999 True False 17018.500640648916 18347.173889984304 14677.942632191687 13844.653250099795 16533.421098512412 15178.793639477355 17187.963229711906 16932.985598420786 15520.280664555477 17990.116363815334 0.9459916932432583 1.0198474272732967 0.8158892547084557 0.7695699666482662 0.9190280242859982 0.8437295975476529 0.9554114538293454 0.9412382474901151 0.8627115217427057 1.0 14.13491689782069 -7.277288772594184 24.003852066649237 0.9349434922318888 0.8848410223273337 0.11623247709287032 0.07264651987241819 1357.3909689389154 2055753.182976115 0.0326200720806972 0.02208830356930653 5.2809399291740175e-08 7.277288772594184 -0.050102469904555025 ADLNQGIGEPQS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 4 ADLNQGIGEPQSPSR 15 0 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 ADLNQGIGEPQS(0.999)PS(0.001)R;ADLNQGIGEPQS(0.614)PS(0.386)R;ADLNQGIGEPQS(0.962)PS(0.038)R;ADLNQGIGEPQS(0.997)PS(0.003)R 227.41 1.0436e-13 596420000.0 315683.7 289089.1 342977.0 384764.0 411259.0 345808.2 357123.7 351483.0 292824.0 326626.0 True False 298139.26373597793 311261.30440203444 320910.23322512273 332358.479445079 359592.96771789173 393440.14061570854 373730.6596771871 352505.757338857 351396.9821861674 317195.45870373433 0.9399228631909412 0.9812918056079659 1.0117113105482953 1.047803397953144 1.1336636696736486 1.240371291012675 1.1782345850867226 1.1113203158059808 1.107824757713123 1.0 18.275012590521257 -5.931149898959455 1.8262513654259005 1.1420963906220554 0.9678750275080342 0.5655767337589929 0.05940746114208452 0.24308546904685177 1.6449260616485992 0.019624834850018792 0.03404645732877649 1.1717908461433694e-06 5.931149898959455 -0.17422136311402114 ADLNQGIGEPQS(ph)PSRR ddPTM_A459_Selumetinib_30min_R2 3 ADLNQGIGEPQSPSRR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 ADLNQGIGEPQS(0.969)PS(0.031)RR;ADLNQGIGEPQS(0.946)PS(0.054)RR;ADLNQGIGEPQS(0.849)PS(0.151)RR 120.08 0.0029319000000000003 75362400.0 59651.0 58031.0 60492.0 59208.0 66668.0 53963.0 52019.0 56418.0 43501.0 61313.0 True False 56335.83622187273 62481.79110092525 56600.010578709705 51143.76826050304 58292.56982051805 61395.913422658756 54437.98657369304 56582.167039497275 52202.41551949445 59542.734379694506 0.9461412346740427 1.049360459371732 0.9505779532693356 0.8589422167676647 0.9790039108515851 1.0311235125875615 0.9142674944444219 0.950278277088886 0.8767218379090215 1.0 15.86163785549966 ADLNQGIGEPQSPS(ph)RR ddPTM_A459_Selumetinib_30min_R1 1 ADLNQGIGEPQSPSRR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 ADLNQGIGEPQS(0.053)PS(0.947)RR 79.317 0.012765 29057000.0 2580.3 2683.7 4324.5 3811.4 3508.0 3108.8 3174.5 2880.0 1707.4 3060.6 True False 2640.415969610204 2369.491156381718 3737.2566527781455 3145.810538838932 3190.702019387701 3077.5282945645577 2935.044909195387 2803.6130444415726 2897.3330964379406 3453.4578227685847 0.764571656906301 0.6861213537225519 1.0821781659351621 0.9109161600580903 0.9239151549358618 0.8911440221665571 0.8498858419074033 0.8118277935689275 0.8389658264640952 1.0 11.753825888721606 -5.22535690803453 24.980700138662606 0.9040781865135167 0.7253464308350935 0.4814551566205234 0.07764790899409892 535.0072657891608 370395.87251659605 0.020418208137575954 0.05401777031698739 5.951728228478957e-06 5.22535690803453 -0.17873175567842314 ADLNQGIGEPQSPS(ph)RR ddPTM_A459_Selumetinib_30min_R2 1 ADLNQGIGEPQSPSRR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 ADLNQGIGEPQS(0.243)PS(0.757)RR 127.91 0.0017919 71502000.0 11013.0 8572.9 8602.8 14249.0 13456.0 10715.0 13053.0 8639.6 10245.0 13430.0 True False 10400.941548532031 9230.4138637818 8049.305214020427 12308.261619103982 11765.536981833711 12190.893988914413 13659.990364028808 8664.739805637228 12294.28626921727 13042.241004669439 0.7974811648403247 0.7077321957535586 0.6171719423938402 0.9437229088695206 0.9021100727721074 0.9347238702727374 1.047365277112898 0.6643597371444862 0.94265136373539 1.0 13.670904163883938 -5.771488637447711 24.999941812618157 0.9105566319233521 0.707488804331766 0.46829382498238037 0.10313630504396186 180.81807078172545 449828.6672761452 0.029132942800254403 0.04378588745112942 1.6924325233814228e-06 5.771488637447711 -0.20306782759158615 ADNDAGNAAIDSLLNYET(ph)VK ddPTM_A459_Selumetinib_30min_R1 2 ADNDAGNAAIDSLLNYETVK 20 0 A0A2R8YF35;A0A2R8Y473;B4DGL8;A0A087WW65;A0A5F9ZA98;O75027-3;O75027;O75027-2 A0A2R8YF35 ABCB7 ATP-binding cassette sub-family B member 7, mitochondrial 1 ADNDAGNAAIDS(0.002)LLNYET(0.998)VK;ADNDAGNAAIDS(0.004)LLNY(0.001)ET(0.995)VK 68.705 0.017625 31490000.0 8461.9 7334.1 3415.3 3598.5 13745.7 4209.799999999999 14247.0 10290.3 880.4 2636.7 True False 8659.04580600883 6475.420162469411 2951.521018900036 2970.089527210973 12502.40386200044 4167.45323419257 13172.337319674503 10017.367816394837 1493.974498128126 2975.1461286329227 2.9104606737376137 2.1765049118595265 0.9920591766886615 0.9983003855261814 4.202282281759816 1.4007558129951456 4.427458938202535 3.367017075224406 0.5021516367717394 1.0 11.538744814889936 -6.210054515875359 24.999669978081 2.6447195199289433 1.7428961915250105 0.05689819972176613 1.3280975317361794 894.0170811692008 434954.77223188174 0.38761060431634836 0.5004026568445091 6.165176071258732e-07 6.210054515875359 -0.9018233284039328 ADNDAGNAAIDSLLNYET(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 ADNDAGNAAIDSLLNYETVK 20 0 A0A2R8YF35;A0A2R8Y473;B4DGL8;A0A087WW65;A0A5F9ZA98;O75027-3;O75027;O75027-2 A0A2R8YF35 ABCB7 ATP-binding cassette sub-family B member 7, mitochondrial 1 ADNDAGNAAIDS(0.006)LLNY(0.011)ET(0.983)VK 63.536 0.027062 117810000.0 17706.0 18939.0 68541.0 99793.0 129510.0 88001.0 50369.0 94193.0 146730.0 64141.0 True False 16721.97140273387 20391.560401516832 64131.14668179829 86201.02124747289 113239.79596591006 100122.3389564589 52711.25830428004 94467.08603550933 176080.099978746 62289.08267166807 0.26845749986200695 0.32736973361773153 1.0295728228948229 1.3838865102869955 1.8179718035471522 1.6073818181624808 0.8462359059311615 1.5165913830109639 2.8268212088927633 1.0 15.926691705629581 -5.4641213573708445 1.7724296522263672 1.5906634453506066 0.2173490022976069 0.5093571287842944 0.5008608633625931 0.32671527206120426 1.9408927506010687 0.15180518260914094 0.46950502814994327 3.4346195896546878e-06 5.4641213573708445 -1.3733144430529998 ADPSLLGFSVNAS(ph)SER ddPTM_A459_Selumetinib_30min_R2 2 ADPSLLGFSVNASSER 16 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 ADPSLLGFSVNAS(0.768)S(0.232)ER;ADPSLLGFS(0.006)VNAS(0.832)S(0.161)ER 168.55 7.5675e-06 1728700.0 11221.6 11781.2 11737.2 13126.3 12275.4 8432.8 11892.0 10430.5 9861.900000000001 9779.3 True False 10597.948395624 12684.780157471361 10982.041330497115 11338.475295869504 10733.25450853163 9594.341654663314 12445.001563550954 10460.851028137766 11834.555564508913 9496.946199327162 1.115932234761406 1.3356693711047927 1.156376070791595 1.1939075001470274 1.1301795633307956 1.010255449835343 1.310421403085621 1.1014962924480813 1.2461432671217372 1.0 13.21324796533189 -11.699018818033583 2.311673246238084 0.5463463416340012 1.1776308569531178 0.24459273789281166 0.09374939697094428 7628916.389979322 1658234.6960823229 18127172.15828243 0.02251368281399297 1.9997752172480784e-12 11.699018818033583 0.6312845153191166 ADQEQQDPLEYLQS(ph)DEEDDEKR ddPTM_A459_Selumetinib_30min_R1 2 ADQEQQDPLEYLQSDEEDDEKR 22 1 Q7RTV3 Q7RTV3 ZNF367 Zinc finger protein 367 1 ADQEQQDPLEYLQS(1)DEEDDEKR;ADQEQQDPLEY(0.002)LQS(0.998)DEEDDEKR 132.88 1.0763e-05 10717200.0 1428.1100000000001 1871.87 1474.2 1295.68 1542.9099999999999 1431.74 1646.33 1305.31 864.73 1391.33 True False 1461.382184381673 1652.7105901912453 1274.0117372009588 1069.4138109258622 1403.3540629228853 1417.3379955159094 1522.1460026321126 1270.688938555566 1467.3836526196435 1569.92075820186 0.9308636609503119 1.0527350387316428 0.8115134031734018 0.681189674917565 0.8939012084471352 0.9028086214614333 0.969568683438222 0.8093968640882071 0.9346864451300972 1.0 10.616476025540546 -6.516077500613108 24.107561951653416 0.9125032035316935 0.8667653113835789 0.057102951216522646 0.09915320714430839 825.1981802595188 2925001.1662906893 0.03500875555768291 0.03633990337373994 3.0473511359409014e-07 6.516077500613108 -0.04573789214811452 ADQEQQDPLEYLQS(ph)DEEDDEKR ddPTM_A459_Selumetinib_30min_R2 2 ADQEQQDPLEYLQSDEEDDEKR 22 1 Q7RTV3 Q7RTV3 ZNF367 Zinc finger protein 367 1 ADQEQQDPLEY(0.001)LQS(0.999)DEEDDEKR;ADQEQQDPLEY(0.001)LQS(0.999)DEEDDEKR 129.5 1.3148e-05 8499700.0 22266.4 22296.6 31065.0 28442.0 23075.0 20300.4 20956.7 18091.2 16073.7 26051.0 True False 21028.92262746151 24006.677525131206 29066.31172101462 24568.15053481332 20176.11220688266 23096.595831316685 21931.228074913255 18143.842396840617 19288.889136702554 25298.839941373302 0.8312208257846305 0.948924044768989 1.1489187562896928 0.9711176714721601 0.7975113583720881 0.9129507868676973 0.8668867080757837 0.7171808050838125 0.7624416448106708 1.0 14.626783612326808 -6.216069286946186 7.258334635248251 0.8334444606210342 0.9862865591972718 0.2766292556621823 0.10349446036450981 0.3247241548301299 44.73962196025072 0.031823065613354976 0.040921468432760205 6.080379877132989e-07 6.216069286946186 0.15284209857623765 ADRDESSPYAAMLAAQDVAQR ddPTM_A459_Selumetinib_30min_R1 5 ADRDESSPYAAMLAAQDVAQR 21 1 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 ;;;; 203.71 1.4009e-16 129426000.0 18323.3 21534.3 21303.1 22028.5 20118.5 18655.300000000003 20056.5 18703.600000000002 10428.0 16518.2 False True 18750.197239064702 19013.05414497553 18410.256029552125 18181.636001157964 18298.78522720966 18467.644619657167 18543.622057419205 18207.519770144954 17695.554369014204 18638.47187089329 1.0059943416469614 1.0200972631596052 0.9877556570666313 0.9754896285006743 0.9817749735044482 0.9908346965127064 0.9949110734972749 0.9768783565662735 0.9494101496941072 1.0 14.18599596085828 -5.3723887380211846 4.676151551608372 0.9813858432528767 1.0128510144881981 0.46263376500217146 0.013439130459765433 0.18858711339971332 6.428237267616605 0.003628644328759953 0.0079228813116053 4.242396560207551e-06 5.3723887380211846 0.03146517123532144 ADRDESSPYAAMLAAQDVAQR ddPTM_A459_Selumetinib_30min_R2 6 ADRDESSPYAAMLAAQDVAQR 21 1 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 ;;;;; 163.15 1.2439e-07 52407100.0 210646.0 185901.0 210336.0 224586.0 251403.0 215306.0 206954.0 210996.1 174801.1 224749.0 False True 198939.1386027493 200159.00893407135 196803.2107565214 193996.9993675404 219819.50756866383 244962.44714672933 216577.77107157107 211610.06371871548 209766.20435081274 218259.91240196937 0.9114781382133198 0.9170672100584298 0.9016919716987188 0.8888347715005771 1.0071455868809391 1.1223428271866154 0.9922929441697003 0.9695324321811013 0.9610844338858078 1.0 17.73568765062108 -6.269234449223051 22.792451975355274 1.0120681646419887 0.9054268157054587 0.5952634210365397 0.041942133199900804 133.56970753923198 390551.25410688395 0.014189653033832026 0.016423002794840547 5.37979281760102e-07 6.269234449223051 -0.10664134893652999 ADRDQS(ph)PFSK ddPTM_A459_Selumetinib_30min_R1 2 ADRDQSPFSK 10 1 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 ADRDQS(0.975)PFS(0.025)K;ADRDQS(1)PFSK 165.35 0.0017049 326470000.0 11671.1 12441.900000000001 13685.1 13625.5 11556.099999999999 11104.4 13186.8 11283.8 7492.299999999999 9263.6 True False 11943.01392199266 10985.196563917609 11826.73858687345 11246.06220731225 10510.852795395158 10992.699817988507 12192.109059246417 10984.51696905202 12713.885884058793 10452.673295105224 1.1425798534797154 1.0509461315567716 1.1314558728638033 1.0759029666198938 1.0055659924162346 1.0516639626664852 1.166410612389056 1.0508811151876187 1.2163286391063661 1.0 13.351584341603246 -7.222180610643544 24.997475058556823 1.112645285444696 1.074464334717997 0.05132032135096287 0.06622272997364019 1513.8209394526486 963905.9209378192 0.02419738163629472 0.018742496759907405 5.99541692175082e-08 7.222180610643544 -0.038180950726699026 ADRDQS(ph)PFSK ddPTM_A459_Selumetinib_30min_R2 3 ADRDQSPFSK 10 1 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 ADRDQS(0.99)PFS(0.01)K;ADRDQS(0.998)PFS(0.002)K;ADRDQS(1)PFSK 149.23 0.0035907 501467000.0 858666.0 787037.0 862002.0 936766.0 859575.0 597703.0 740805.0 724989.0 593425.0 758782.0 True False 810944.781232344 847400.207177178 806541.7297968132 809176.8547885147 751587.5038020003 680031.1628423808 775253.9003772595 727098.5979616103 712126.5816798693 736873.9921076013 1.1005202923676083 1.149993372345047 1.0945449811438572 1.0981210674488773 1.0199674732070751 0.9228594985383607 1.05208476439762 0.9867339677466002 0.966415682066686 1.0 19.491058409219818 -6.288479144683348 2.976296984307309 0.9874947294506257 1.115569152211014 0.7614703189072011 0.03320653340280908 0.12624897917039707 2.257436979337443 0.010651410689515643 0.013048951649309177 5.146605210058916e-07 6.288479144683348 0.12807442276038838 ADREVQAEQPSSS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 ADREVQAEQPSSSSPR 16 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 ADREVQAEQPSS(0.001)S(0.645)S(0.354)PR 132.62 0.0010058 0.0 655.11 617.68 1248.4 1226.3 1177.2 978.68 800.18 624.65 502.69 425.87 True False 670.3727883778404 545.3617384483588 1078.8741369703407 1012.149725501963 1070.722467851541 968.8353677703416 739.8217783713858 608.0822528508437 853.0282149750428 480.53456282508574 1.3950563398326368 1.1349063743555738 2.2451540855408774 2.106299533485138 2.228190333608289 2.0161616722728786 1.539580782747318 1.2654287535029718 1.7751651618148943 1.0 8.908496391477325 -7.441757236771558 4.792794988559744 1.3908939355365881 1.8658376537866475 0.26901048252204507 0.3780445523080244 0.35213186810485014 14.298521899320237 0.1816371054393459 0.11786851846452587 3.6161194107952964e-08 7.441757236771558 0.4749437182500593 ADREVQAEQPSSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ADREVQAEQPSSSSPR 16 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 ADREVQAEQPSSS(0.224)S(0.776)PR;ADREVQAEQPSSS(0.099)S(0.901)PR 198.61 4.3879e-06 21200700.0 4996.4 4156.9 11156.0 12457.6 8814.5 6162.299999999999 5853.5 5296.0 3837.9 3875.1 True False 5112.806398697993 3670.2082155096164 9641.076475521566 10282.114018114053 8017.2300313263695 6100.31285692073 5411.965782320111 5155.532876167561 6512.635990874528 4372.5068316704355 1.1693078125494294 0.8393830717258093 2.2049311405737404 2.351537553615659 1.8335546037931598 1.3951522757461807 1.237726089555947 1.1790794330669998 1.4894513014143183 1.0 12.094244922899206 -6.93509911184271 4.665247764371668 1.249497394284766 1.6977648336623872 0.19859510690701843 0.42960525544228434 0.4040642934017516 17.41116314190513 0.1768053641417585 0.15362337657081232 1.1611835858859864e-07 6.93509911184271 0.44826743937762115 ADREVQAEQPSSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ADREVQAEQPSSSSPR 16 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 ADREVQAEQPS(0.005)S(0.043)S(0.236)S(0.715)PR;ADREVQAEQPS(0.001)S(0.003)S(0.096)S(0.899)PR 111.73 0.0014138 13228300.0 20380.0 29172.0 27086.0 32616.0 29747.0 17850.0 9153.2 16293.8 10092.8 32114.0 True False 19247.361187603994 31409.39859723578 25343.31624900699 28173.644534261704 26009.915918445877 20308.675473833155 9578.84193672171 16341.2122604162 12111.642016393944 31186.785377807475 0.6171639992527227 1.0071380623790331 0.8126299630432992 0.9033840517051198 0.8340043901079507 0.6511948964218933 0.3071442542307684 0.5239787320960823 0.3883581417471963 1.0 14.92864723208495 -6.90460892721455 3.72293882829698 0.5108839147369122 0.8470213203475521 0.30478351956996286 0.19515514181814514 0.22845790314530096 6.108101502781466 0.067645027196003 0.05878540849234673 1.2456357749713658e-07 6.90460892721455 0.33613740561063987 ADS(ph)EASSGPVTEDK ddPTM_A459_Selumetinib_30min_R2 1 ADSEASSGPVTEDK 14 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 ADS(1)EASSGPVTEDK 122.97 0.0020043 0.0 7142.3 7645.3 5929.9 8733.5 8138.4 5976.4 7890.9 9384.5 6397.0 8622.8 True False 6745.359558892247 8231.669926485902 5548.376689986949 7543.982233872166 7115.9814337808775 6799.594851642381 8257.842485521714 9411.807341312386 7676.578747113994 8373.837359275032 0.8055278923492525 0.9830224272708541 0.6625847209513156 0.9008990633805777 0.8497873947717736 0.8120046473211009 0.9861479428395108 1.1239539219002954 0.9167336810776793 1.0 13.031673182290577 -7.342343713232884 4.866799628068326 1.0213921527495802 0.8381789943155687 0.46719908757858786 0.08943992713693903 0.1915116744746514 8.07942972410206 0.03683415695756014 0.024497394517790073 4.546281118754572e-08 7.342343713232884 -0.18321315843401142 ADS(ph)LLAVVK ddPTM_A459_Selumetinib_30min_R1 2 ADSLLAVVK 9 0 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 ADS(1)LLAVVK;ADS(1)LLAVVK 132.25 0.0034083 18655000.0 7284.0 9227.3 7965.9 8698.0 7569.0 8214.2 9301.2 8584.1 5034.799999999999 7585.2 True False 7453.70302780325 8146.963426344608 6884.174533556582 7179.05758168155 6884.385286415482 8131.572605896867 8599.60299556092 8356.421782913516 8543.687872757258 8558.83430610477 0.870878295013462 0.9518776897612813 0.8043355306745801 0.8387891767645197 0.804360154688945 0.9500794518357306 1.0047633460349932 0.9763504566215425 0.9982303158577671 1.0 13.063198602863125 -6.931774707194033 5.269165940992797 0.991083290070131 0.8563496373169951 0.7409275685469026 0.039609917631158495 0.11378701061047455 5.961087383404127 0.015237727017747709 0.013326227050314086 1.1701062330660513e-07 6.931774707194033 -0.13473365275313587 ADS(ph)LLAVVK ddPTM_A459_Selumetinib_30min_R2 1 ADSLLAVVK 9 0 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 ADS(1)LLAVVK 91.937 0.026557 2906400.0 36589.0 29627.0 34843.0 36878.0 28858.0 25211.0 27334.0 27636.0 23615.0 28265.0 True False 34555.52985737208 31899.295634180206 32601.239314190025 31855.152781901645 25232.60004620669 28683.58640732816 28605.085161293468 27716.4161846139 28338.65985822994 27448.91600871046 1.2589032603839967 1.162133164896475 1.1877058935166898 1.1605249829098145 0.9192567035506809 1.0449806614667732 1.0421207581463732 1.0097453821425426 1.0324145350307143 1.0 14.744461556111911 -6.10993377777411 5.777761429669911 1.0125750970148346 1.1950715473872529 0.8327311724828956 0.04067400077159193 0.09161057325148232 4.112446439945095 0.011958039012739447 0.015608785747950884 7.763654896069532e-07 6.10993377777411 0.18249645037241824 ADS(ph)PAGPESSR ddPTM_A459_Selumetinib_30min_R2 1 ADSPAGPESSR 11 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 ADS(0.999)PAGPESSR 81.23899999999998 0.042264 4479600.0 14325.0 17372.0 17309.0 19627.0 23567.0 19052.0 17682.0 16057.0 12381.0 15487.0 True False 13528.87384751851 18704.376540215977 16195.357784614269 16953.768741536507 20606.302768346846 21676.240063163557 18504.24803621831 16103.723211620554 14857.54595404382 15039.850069941594 0.8995351539146724 1.2436544548803878 1.0768297362872024 1.1272564994128524 1.3701135764332038 1.441253733405584 1.2303479057414677 1.070736951281529 0.9878785948629818 1.0 13.876502564621523 -7.915444674630271 3.8338580303177854 1.0019900107364164 1.2082902603125902 0.25724443565176625 0.14211120004927882 0.32980362780045275 9.234048360070123 0.0948354099287571 0.04106335035366176 1.214941383662548e-08 7.915444674630271 0.20630024957617388 ADS(ph)PAGPESSRR ddPTM_A459_Selumetinib_30min_R1 1 ADSPAGPESSRR 12 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 ADS(1)PAGPESSRR 103.13 0.0056335000000000005 2169400.0 522.7 355.16 777.42 589.71 501.43 513.12 452.5 402.26 271.67 421.22 True False 534.8778930028501 313.5777020905953 671.850634062386 486.7282187276875 456.0757450346568 507.95847867568364 418.36756069015985 391.59075807537096 461.0041480082554 475.28769003024973 1.1253771225777123 0.6597639885658255 1.4135662424154642 1.0240707448087065 0.9595782819572495 1.0687389750055478 0.8802406825717132 0.8239025884521607 0.9699475868582137 1.0 8.892657226040901 -7.263634844067289 24.719059186602788 0.9038479261651744 1.036830242948876 0.09992945207927306 0.1787907467641346 402.0251247224914 4526413.3444148125 0.07111538075721535 0.05056599357649168 5.449606646143651e-08 7.263634844067289 0.13298231678370165 ADS(ph)PLEQPEGSPLTQDDR ddPTM_A459_Selumetinib_30min_R2 2 ADSPLEQPEGSPLTQDDR 18 0 P09603-3;P09603-2;P09603 P09603-3 CSF1 Macrophage colony-stimulating factor 1;Processed macrophage colony-stimulating factor 1 1 ADS(1)PLEQPEGSPLTQDDR;ADS(1)PLEQPEGSPLTQDDR 312.86 1.1364999999999997e-111 4981000.0 13441.7 6259.8 12606.4 14966.7 12334.099999999999 9473.099999999999 24933.2 15853.5 10884.4 9387.900000000001 True False 12694.66412538846 6739.906531570573 11795.317948810523 12928.209641002419 10784.580089746974 10777.933536760165 26092.643204198514 15899.631060311784 13061.584135545962 9116.846934306495 1.3924401952629826 0.7392804310675056 1.2937935707163186 1.4180571127451804 1.1829287216795135 1.1821996809229118 2.8620249294756137 1.7439835476980337 1.4326865669308877 1.0 13.154319238572867 ADS(ph)PVNGLPK ddPTM_A459_Selumetinib_30min_R1 2 ADSPVNGLPK 10 0 Q96S94;Q96S94-3;A0A0A0MSF3 Q96S94 CCNL2 Cyclin-L2 1 ADS(1)PVNGLPK;ADS(1)PVNGLPK 142.76 0.0011637000000000002 125218000.0 19704.7 20272.5 22554.7 21785.0 17661.2 17733.3 18188.1 17368.0 11801.1 16119.2 True False 20163.78117132823 17898.98627557044 19491.8956240988 17980.65870509685 16063.747578338112 17554.919102548134 16816.156973676687 16907.344220785162 20025.6047817581 18188.256334304173 1.108615405496463 0.9840957784288453 1.071674781014378 0.9885861720116742 0.88319337945776 0.9651787823903973 0.9245612479059017 0.9295747712163518 1.101018394159564 1.0 14.150719621360741 -5.9279630138305395 5.603433735252207 0.9593280513764122 1.046654153866134 0.27925963285567845 0.06171234773764865 0.25753808750959056 14.490471179050479 0.017221748455870763 0.02578702999827784 1.1804211605256475e-06 5.9279630138305395 0.08732610248972184 ADS(ph)PVNGLPK ddPTM_A459_Selumetinib_30min_R2 3 ADSPVNGLPK 10 0 Q96S94;Q96S94-3;A0A0A0MSF3 Q96S94 CCNL2 Cyclin-L2 1 ADS(1)PVNGLPK;ADS(1)PVNGLPK;ADS(1)PVNGLPK 104.94 0.012817 115672000.0 551000.0 529450.0 593840.0 601830.0 608960.0 471480.0 536260.0 505760.0 415230.0 507600.0 True False 520377.6258277622 570057.1125499277 555632.9809241061 519859.7157853424 532457.0006285268 536422.090330692 561197.1525790311 507231.67786692426 498287.6024955682 492944.2690968125 1.0556520451717877 1.1564331878619942 1.1271720065681132 1.0546013989326728 1.08015658971776 1.088200277312364 1.1384596348128229 1.028983821632189 1.0108396298197075 1.0 18.91106502318496 -7.896891648023146 5.802412332139139 1.0101039004045935 1.100127593838668 0.614337917630132 0.03180049932152948 0.1429903292115673 6.801555659970715 0.01849512268572347 0.008700919042826183 1.2679681713298261e-08 7.896891648023146 0.09002369343407457 ADS(ph)VPGTYR ddPTM_A459_Selumetinib_30min_R2 1 ADSVPGTYR 9 0 A0A0U1RQC1;H0YKX3;H0YMA4;A0A0U1RQM0;Q15004-2;Q15004 A0A0U1RQC1 KIAA0101 PCNA-associated factor 1 ADS(0.927)VPGT(0.073)YR 100.69 0.017694 7666100.0 40666.0 52195.0 49432.0 62938.0 56899.0 39687.0 48385.0 47399.0 47004.0 53869.0 True False 38405.94651889618 56198.188666622846 46251.59893749217 54365.73582589419 49750.83893648609 45153.524007283835 50634.99837305862 47536.92324267313 56406.113401492286 52313.66200152929 0.7341475448186643 1.0742545353636304 0.8841208427760247 1.0392263463472489 0.9510104441748262 0.8631306293557477 0.9679115633613721 0.9086904151593036 1.078229113454978 1.0 15.674900142999293 -4.74386065918448 24.985367926006802 0.9660566151292664 0.7341468302494344 0.49807186888938393 0.07184941237648913 937.5549483210018 1332515.1016394051 0.01693321719584385 0.5154972330838234 1.8035963212483484e-05 4.74386065918448 -0.23190978487983205 ADSEGSNSGGT(ph)WPK ddPTM_A459_Selumetinib_30min_R1 1 ADSEGSNSGGTWPK 14 0 Q8TDM6-4;Q8TDM6;Q8TDM6-3 Q8TDM6-4 DLG5 Disks large homolog 5 1 ADSEGSNSGGT(1)WPK 162.7 3.9568e-06 0.0 2578.1 3060.8 2565.3 2580.9 2577.5 2432.0 2476.2 2589.8 1543.5 2171.7 True False 2638.164713890661 2702.4401130726847 2216.946350184248 2130.194264493206 2344.3655800945858 2407.5362880793227 2289.4182403999434 2521.110091144024 2619.2067672203134 2450.4588491493605 1.0766002925560083 1.102830236880246 0.9047066229877017 0.8693042387684538 0.9567047334454919 0.9824838678335946 0.9342814474091985 1.0288318418483906 1.0688638040706258 1.0 11.25883620426157 -9.911478397160964 10.562076026221362 0.9999902099403583 0.9868541983036866 0.0 0.07365507607912439 0.0 0.0 0.07815760412453757 0.018956003367686998 1.2260878896848423e-10 9.911478397160964 -0.013136011636671663 ADSEGSNSGGT(ph)WPK ddPTM_A459_Selumetinib_30min_R2 2 ADSEGSNSGGTWPK 14 0 Q8TDM6-4;Q8TDM6;Q8TDM6-3 Q8TDM6-4 DLG5 Disks large homolog 5 1 ADSEGSNSGGT(1)WPK;ADSEGSNS(0.001)GGT(0.999)WPK 142.54 0.00072513 6912600.0 62285.0 46864.0 50121.0 48749.0 58219.0 40425.0 56545.0 51406.0 45147.0 49905.0 True False 58823.449046610134 50458.31810848958 46896.26942761866 42109.30210328444 50905.008735536365 45993.17680838688 59174.45454179191 51555.58294927861 54177.661512577026 48464.112981238155 1.2137527219240012 1.0411480785385143 0.9676493913294885 0.8688759478500341 1.0503650145261743 0.9490151367506129 1.220995307697059 1.0637888486525535 1.1178923574553143 1.0 15.564629226060518 -7.23907308649046 24.965844976046757 1.1059848982992682 1.009111699785729 0.15217416636892633 0.09797213940009447 1397.8204324703338 1560285.2879458612 0.038187834767338884 0.029555589833331564 5.766694087632135e-08 7.23907308649046 -0.09687319851353915 ADSEPES(ph)PLNASYVYK ddPTM_A459_Selumetinib_30min_R1 2 ADSEPESPLNASYVYK 16 0 Q5T1V6;Q5T1V6-2 Q5T1V6 DDX59 Probable ATP-dependent RNA helicase DDX59 1 ADSEPES(1)PLNASYVYK;ADS(0.004)EPES(0.996)PLNASYVYK 233.37 1.3598e-15 25445900.0 4858.3 5081.299999999999 5418.9 5291.2 5428.0 4539.2 5045.3 5278.1 2843.51 3944.4 True False 4971.488937393818 4486.379033767718 4683.04314388704 4367.191248125245 4937.038358391237 4493.539769263844 4664.728959005666 5138.107642314953 4825.228788246605 4450.702161709599 1.1170122728419496 1.0080160097804467 1.0522032195675377 0.9812364632477955 1.1092717910593297 1.0096249099575314 1.0480883216894152 1.1544487713689897 1.0841500089040206 1.0 12.119817244404972 -7.561507256220621 24.999753826720124 1.0918334006164159 1.0433555400940613 0.05914294454103475 0.053392001278834846 304.36516681204364 196977.2814984034 0.02355659114726529 0.01360044054412379 2.7446864846940482e-08 7.561507256220621 -0.04847786052235459 ADSGPTQPPLSLS(ph)PAPETK ddPTM_A459_Selumetinib_30min_R1 3 ADSGPTQPPLSLSPAPETK 19 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 O15027 SEC16A Protein transport protein Sec16A 1 ADSGPTQPPLS(0.005)LS(0.995)PAPETK;ADSGPTQPPLS(0.004)LS(0.996)PAPETK;ADSGPTQPPLS(0.215)LS(0.785)PAPETK 230.62 6.6308e-30 233670000.0 10865.5 12025.6 14092.0 14579.2 13360.800000000001 10555.609999999999 12482.8 12944.0 7733.5 10607.18 True False 11118.645009417387 10617.637161450231 12178.383801815156 12033.216405478453 12152.317999040835 10449.430147127048 11541.212346040063 12600.683071962407 13123.184667507807 11968.714875682705 0.9289756774144201 0.8871158910320849 1.0175180817915919 1.0053891775738428 1.015340253758669 0.8730620000278856 0.964281668158775 1.052801675271227 1.0964572891756894 1.0 13.546980632748696 -7.754431958771699 5.809434816905508 1.0568799841989873 0.9563045437026224 0.40584587583816334 0.051885370947989486 0.16059701249150898 18.735586459500965 0.02821464130164513 0.014774644660876936 1.7602244178229893e-08 7.754431958771699 -0.10057544049636491 ADSGPTQPPLSLS(ph)PAPETK ddPTM_A459_Selumetinib_30min_R2 4 ADSGPTQPPLSLSPAPETK 19 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 O15027 SEC16A Protein transport protein Sec16A 1 ADSGPT(0.001)QPPLS(0.36)LS(0.578)PAPET(0.061)K;ADSGPTQPPLS(0.013)LS(0.987)PAPETK;ADSGPTQPPLS(0.088)LS(0.912)PAPETK;ADSGPTQPPLS(0.169)LS(0.83)PAPETK 165.9 6.9589e-09 384362000.0 675711.0 612531.0 739820.0 750410.0 796060.0 430957.0 539764.0 601198.0 457206.0 550126.0 True False 638157.6877054506 659510.1581024083 692220.7866551132 648202.8634705459 696051.8259333052 490317.4149118604 564864.095522075 602947.3866463129 548659.9754030025 534242.4329809957 1.1945095490536435 1.2344773035388386 1.2957053650579964 1.2133122033262453 1.3028763403338002 0.9177807389352433 1.0573179153333343 1.1286025770771397 1.026986891216332 1.0 19.027135043109254 -6.750687910241194 24.99999695443703 1.036124046019487 1.248118751375389 0.7834519447991026 0.05824905015074405 103.31259879571942 240228.6198789067 0.01965778125029308 0.019469114000360634 1.775464895126986e-07 6.750687910241194 0.21199470535590215 ADT(ph)PGPEDGGVK ddPTM_A459_Selumetinib_30min_R1 2 ADTPGPEDGGVK 12 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ADT(1)PGPEDGGVK;ADT(1)PGPEDGGVK 187.62 0.00027613 12291300.0 6237.2 6706.4 6042.5 6628.5 5177.299999999999 5422.7 5997.1 6284.2 3636.8 5276.8 True False 6382.514624521478 5921.211570279226 5221.961689076647 5470.956907355272 4709.014129126555 5368.152561417659 5544.733918707088 6117.5226020415785 6171.383978637402 5954.12868038465 1.071947713449343 0.99447154875677 0.8770320511009341 0.9188509689719767 0.7908821562153983 0.901584908485865 0.9312418686841156 1.0274421213292242 1.0364881765099367 1.0 12.539674686040973 -7.734322121476441 5.474841345969939 1.0246254641946502 0.92019434286032 0.2780983563148054 0.0694874880276854 0.2371848406515399 19.494682925542875 0.03845503086536462 0.020676472973801915 1.8436474562803636e-08 7.734322121476441 -0.10443112133433019 ADT(ph)PGPEDGGVK ddPTM_A459_Selumetinib_30min_R2 2 ADTPGPEDGGVK 12 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ADT(1)PGPEDGGVK;ADT(1)PGPEDGGVK 166.45 0.0010991 22256000.0 206090.0 167298.0 177400.0 170940.0 157555.0 128737.0 162412.0 151312.0 116078.0 157345.0 True False 194636.34284363638 180129.21865214396 165986.27713851587 147657.67711205222 137761.53234042882 146469.35319186893 169964.47981327283 151752.29286894976 139296.8434903073 152802.04101859347 1.2737810407908907 1.178840396707955 1.0862831152780092 0.9663331466500812 0.9015686663744598 0.9585562615230122 1.1123181253357144 0.9931300122521532 0.911616380002131 1.0 17.22130428841085 -5.288618486905696 1.7573211193162501 0.9792347656012058 1.2671909323832034 0.7594139714867911 0.05651856990569705 0.22457023531143364 1.2112284925184924 0.017878665437090446 0.07621240149165559 5.144954200424742e-06 5.288618486905696 0.28795616678199754 ADT(ph)SQEICSPR ddPTM_A459_Selumetinib_30min_R1 1 ADTSQEICSPR 11 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ADT(0.618)S(0.382)QEICSPR 133.88 0.0040609 9650400.0 1921.9 2015.0 2520.8 2528.0 2091.1 2185.5 2141.4 1861.5 1150.0 1824.4 True False 1966.6765306335903 1779.0828632519137 2178.489205763246 2086.53225643722 1901.96037421369 2163.5158542752306 1979.8724739489683 1812.12697299583 1951.4660073231998 2058.5795111608845 0.9553561181246443 0.8642283932227832 1.0582487554900133 1.0135786570908656 0.923918830388595 1.0509751226733866 0.9617663360656244 0.8802802919057162 0.9479672739105032 1.0 11.00743345746126 -9.939977269511498 9.22958828606773 0.9999981134644623 0.9624104627409615 0.033498990568696985 0.06145920219199754 0.0 0.0 0.0612891953846814 0.014864813310597642 1.1482137161486998e-10 9.939977269511498 -0.03758765072350079 ADT(ph)SQEICSPR ddPTM_A459_Selumetinib_30min_R2 1 ADTSQEICSPR 11 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ADT(0.609)S(0.391)QEICSPR 113.76 0.01617 16859000.0 53691.0 40316.0 51710.0 56775.0 53146.0 46635.0 41639.0 50989.0 44068.0 45680.0 True False 50707.069162102394 43408.1075636281 48383.03489759105 49042.14705766214 46469.324348731745 53058.54793961958 43575.296006113225 51137.36954831664 52882.83136279812 44361.09970910648 1.143052572966157 0.9785173913242113 1.0906635591736458 1.1055214451231183 1.047524174410683 1.1960602484506868 0.9822861987609396 1.1527525215480428 1.1920991974854558 1.0 15.437007509819338 -5.499167117094984 24.666973595678204 1.100136145473471 1.054236357458161 0.029186021780680194 0.07794977869832416 1987.4157123811863 2067486.149965477 0.019469468813972806 0.04010632020066452 3.1683480438949167e-06 5.499167117094984 -0.04589978801531003 ADTS(ph)QEICSPR ddPTM_A459_Selumetinib_30min_R1 2 ADTSQEICSPR 11 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ADT(0.053)S(0.947)QEICSPR;ADT(0.095)S(0.905)QEICSPR 111.31 0.008318700000000002 38480000.0 5687.6 7203.700000000001 7000.7 7559.1 6533.0 6086.6 6151.4 5608.6 3495.1000000000004 5547.0 True False 5820.110013856915 6360.287455090728 6050.043392092489 6239.0450868807775 5942.091303494828 6025.374330190632 5687.3949454794465 5459.841708699656 5930.92942799593 6259.01148235553 0.929876871174322 1.0161808255218416 0.9666132438241833 0.9968099762189224 0.949365777686442 0.9626718767294911 0.9086730327165082 0.8723169344058924 0.9475824488763954 1.0 12.61171910761622 -6.9231610197659315 2.056212071301528 0.9227139079357987 0.977148477677634 0.16865069415625478 0.03804498834267477 0.41229475773030955 3.5451349565401675 0.015550890011176214 0.012787609981160582 1.1935455014449022e-07 6.9231610197659315 0.05443456974183536 ADTS(ph)QEICSPR ddPTM_A459_Selumetinib_30min_R2 3 ADTSQEICSPR 11 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ADT(0.052)S(0.948)QEICSPR;ADT(0.04)S(0.956)QEICS(0.004)PR;ADT(0.099)S(0.901)QEICSPR 149.32 0.00063322 58998000.0 192536.0 168649.0 225380.0 228989.0 237313.0 186187.0 175442.0 207109.0 164222.0 200807.0 True False 181835.61990267536 181583.83600799486 210879.29617518993 197800.3031719421 207499.6193348622 211832.5692126932 183600.40063172788 207711.6529012592 197070.988746061 195009.18015075647 0.9324464610440546 0.9311553223679889 1.081381379133868 1.0143127775781011 1.0640505189265945 1.086269728681137 0.9414961925884271 1.0651378193615437 1.0105728796650013 1.0 17.573182515571844 -5.244020805136466 24.34320418156867 1.0343189603421705 0.9318008522867169 0.48274656923066084 0.0418405753210366 470.4496073103651 657469.5485560794 0.010304853049878314 0.027120531870325006 5.701369588750857e-06 5.244020805136466 -0.10251810805545358 ADTSQEICS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ADTSQEICSPR 11 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ADTSQEICS(1)PR;ADT(0.002)S(0.033)QEICS(0.965)PR 113.52 0.0070489 26459800.0 5797.9 7109.799999999999 5738.2 6791.2 6383.2 6038.9 6694.0 6324.9 3109.8 5132.0 True False 5932.979789250478 6277.381310743654 4958.983957676392 5605.244406612522 5805.840687045495 5978.154148882491 6189.066190629685 6157.143105829342 5277.1034691945115 5790.742189913208 1.024562930738832 1.0840374350766495 0.856364140388491 0.9679664925121686 1.0026073509469282 1.0323640654035218 1.068786346836561 1.0632735673424318 0.9113000192594665 1.0 12.49953255258055 -6.518571006907357 5.007204879745422 1.022202963136186 0.9815943917658423 0.04257147420897478 0.06705811128074367 0.5671024484999087 41.58297193543642 0.022880465683237573 0.0242553010404679 3.029904869519594e-07 6.518571006907357 -0.04060857137034368 ADTSS(ph)QGALVFLSK ddPTM_A459_Selumetinib_30min_R2 2 ADTSSQGALVFLSK 14 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 ADTS(0.027)S(0.973)QGALVFLSK;ADT(0.018)S(0.437)S(0.545)QGALVFLSK 178.03 5.093700000000001e-10 3002300.0 29649.0 29725.0 34749.0 39321.0 38830.0 27948.0 26731.0 30533.0 23776.0 31287.0 True False 28001.227274350884 32004.81191906053 32513.287171850567 33965.41196749157 33951.828255395616 31797.58331331592 27974.044466471623 30621.845974989745 28531.86435694578 30383.663016611536 0.921588264688227 1.0533559400511607 1.0700910931665715 1.1178840401475556 1.117436967255504 1.0465355443131186 0.9206936125896831 1.0078391785166914 0.9390528173428817 1.0 14.891008189393856 -7.12899147760264 6.328872023920559 0.9680073982044887 1.0621147214075617 0.3648581046595304 0.05637880362675603 0.2675564863757657 12.628089290683102 0.022540060959399807 0.017431090645003276 7.4303371870934e-08 7.12899147760264 0.09410732320307302 ADVEAS(ph)PGNPPDR ddPTM_A459_Selumetinib_30min_R2 1 ADVEASPGNPPDR 13 0 Q9NW97 Q9NW97 TMEM51 Transmembrane protein 51 1 ADVEAS(1)PGNPPDR 89.624 0.022212 8386300.0 40059.0 21715.0 29420.0 30744.0 27324.0 20997.0 45030.0 51711.0 25685.0 35952.0 True False 37832.68114888265 23380.470675269964 27527.149230074054 26556.614163641836 23891.3148403407 23889.14615821149 47123.98422525224 51861.47044878313 30822.717698862412 34913.97234548592 1.0835971563050772 0.6696594258571342 0.7884278808977484 0.7606299821989572 0.6842909367037304 0.6842288216826222 1.3497170633849396 1.485407330211407 0.8828189870193195 1.0 15.091516888749041 -7.257946878765791 24.963353654368763 1.2199364634488221 0.7688868470147019 0.5038915651355318 0.1931321359504299 221.08093978729318 1580227.8898242475 0.07410123402493328 0.0550556379231389 5.521449714043136e-08 7.257946878765791 -0.4510496164341202 ADVLEAHEAEAEEPEAGKS(ph)EAEDDEDEVDDLPSSR ddPTM_A459_Selumetinib_30min_R1 1 ADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSR 35 1 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 ADVLEAHEAEAEEPEAGKS(1)EAEDDEDEVDDLPSSR 94.495 1.3234e-11 22369000.0 3008.9 3898.1 3949.2 4427.2 3269.6 3409.5 3716.6 3200.3 1874.9 3741.1 True False 3079.00151569978 3441.7086398224747 3412.920331402814 3654.0726288365745 2973.865257294766 3375.2035255783126 3436.253869748173 3115.4176479605458 3181.5683627219705 4221.306626399904 0.7293953716708974 0.8153183230751704 0.8084985606254067 0.8656259666104641 0.704489277963443 0.7995636953899316 0.814026123631475 0.7380221158247147 0.7536927885845944 1.0 12.043473911948645 -10.680875575607264 5.4609776063483375 1.0000054669241774 0.7832776686249459 0.6654060862904854 0.04657132581260611 3.10203689860241e-06 4.78314939008143e-07 0.04512509714509948 0.010944167673938836 2.0850881706058723e-11 10.680875575607264 -0.2167277982992315 ADVLEAHEAEAEEPEAGKS(ph)EAEDDEDEVDDLPSSR ddPTM_A459_Selumetinib_30min_R2 1 ADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSR 35 1 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 ADVLEAHEAEAEEPEAGKS(0.999)EAEDDEDEVDDLPSSR 76.423 2.3277e-06 8838200.0 108860.0 95902.0 95449.0 98474.0 93590.0 74560.0 96050.0 93414.0 60626.0 85626.0 True False 102809.99700110762 103257.37502646753 89307.91525701374 85061.67132287512 81832.38749478427 84829.96321170864 100516.5153194642 93685.81927447986 72752.89403197315 83153.75489693426 1.236384299524856 1.2417644296935346 1.074009410251014 1.0229444410334283 0.9841093477523922 1.0201579389511872 1.2088030834452441 1.1266577124580803 0.874920129850389 1.0 16.343493790973902 -5.304831348680221 3.982547392048557 1.044263704348782 1.24243179615718 0.4820601744401577 0.08327964980096222 0.19265594943745268 6.584906676457972 0.02323215526621893 0.05609703025242687 4.956426283291373e-06 5.304831348680221 0.19816809180839812 ADVPVEKYDGES(ph)DKEQFDDDQK ddPTM_A459_Selumetinib_30min_R1 1 ADVPVEKYDGESDKEQFDDDQK 22 2 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 ADVPVEKY(0.081)DGES(0.919)DKEQFDDDQK 85.855 0.00068732 5911700.0 602.89 756.69 603.06 759.1 549.96 576.55 486.52 653.52 449.59 565.87 True False 616.9361639802725 668.0963830243627 521.1677643714623 626.537435071794 500.2162151033244 570.7504304655151 449.82140470050064 636.1865266678672 762.9213932455978 638.5049265405671 0.9662198964115208 1.046344914900066 0.8162313910327366 0.9812570099754543 0.7834179413673535 0.8938857113567671 0.7044916742266066 0.9963690180352075 1.1948559228495255 1.0 9.318553941211299 -7.9983061331885885 24.99983576405813 1.0968228322774516 0.8856265364423633 0.4060142300809625 0.10420957604973063 48.90384849803686 721777.2753670983 0.05755142638925965 0.027330363234764878 1.0039078884303633e-08 7.9983061331885885 -0.21119629583508825 ADVTLSALNDSDANSDVVDIEGLGET(ph)PPAK ddPTM_A459_Selumetinib_30min_R1 1 ADVTLSALNDSDANSDVVDIEGLGETPPAK 30 0 H0YIS7;Q8IXM2;Q8IXM2-3;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 ADVTLSALNDS(0.003)DANS(0.102)DVVDIEGLGET(0.895)PPAK 80.729 2.6697e-05 2200100.0 880.33 1197.9 1141.3 1209.5 1201.8 1091.9 1065.1 1095.5 630.2 1061.3 True False 900.8399761760072 1057.6493111113982 986.3177287121515 998.2835301269058 1093.0974021950235 1080.9164773658779 984.7586494830703 1066.4437813144943 1069.403372013114 1197.5281929374307 0.7522494931550016 0.8831936628707489 0.8236279818121036 0.8336200650760502 0.9127947121760468 0.9026229893715365 0.8223260673868098 0.8905375151950302 0.893008931497439 1.0 10.225843905827912 -14.522878745026608 0.06721870711317737 1.4796526950858815 0.6787014118376277 0.6110838266391379 0.03969413936900556 242.94451390755506 1.1763144232222018 18.427785151515913 2.47602997100048 3.0000000017527024e-15 14.522878745026608 -0.8009512832482538 ADVTPPPDGS(ph)TTHNLEVSPK ddPTM_A459_Selumetinib_30min_R2 1 ADVTPPPDGSTTHNLEVSPK 20 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 ADVTPPPDGS(0.6)T(0.157)T(0.157)HNLEVS(0.085)PK 63.43600000000001 0.013404 11895000.0 29872.0 33875.0 33918.0 37508.0 39757.0 26294.0 33098.0 34962.0 28926.0 33861.0 True False 28211.833827090617 36473.10357470732 31735.752807126155 32399.345695090993 34762.37022791046 29915.759826833004 34637.12258244278 35063.73363172932 34712.008259968636 32883.34494855634 0.8579368635163493 1.1091664680636018 0.9651011129425698 0.9852813254180033 1.057142157596611 0.9097541589407674 1.0533333101188491 1.0663067789053713 1.0556106233801066 1.0 15.005069439373326 ADVTPPPDGSTTHNLEVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 ADVTPPPDGSTTHNLEVSPK 20 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 ADVTPPPDGS(0.026)T(0.026)T(0.022)HNLEVS(0.926)PK;ADVTPPPDGS(0.133)T(0.034)T(0.133)HNLEVS(0.701)PK;ADVTPPPDGS(0.012)T(0.012)T(0.012)HNLEVS(0.963)PK 79.172 0.0031303 12689000.0 9565.3 10751.4 10047.0 9555.5 10084.6 8763.2 9608.2 9566.599999999999 4751.8 7346.299999999999 True False 9788.15287916618 9492.621089809742 8682.67258422062 7886.811303950106 9172.44971058074 8675.050164348979 8883.445738393797 9312.862691303735 8063.457542259464 8289.26916402171 1.180822179312278 1.1451698457339272 1.047459361303698 0.951448330111126 1.1065450438492621 1.0465398085999777 1.0716802124065434 1.1234841705617153 0.9727585608219423 1.0 13.017029194595365 -5.19142643534469 3.7836321085124234 1.044709618151191 1.1718015016903869 0.47766532111902693 0.051768281526053964 0.20448734888362247 5.688612379542799 0.013455474048515664 0.040398318006943955 6.4353706378207245e-06 5.19142643534469 0.12709188353919587 ADVTPPPDGSTTHNLEVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ADVTPPPDGSTTHNLEVSPK 20 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 ADVTPPPDGS(0.011)T(0.013)T(0.043)HNLEVS(0.932)PK 84.318 0.0017058 17673000.0 47020.0 40738.0 46693.0 50597.0 46997.0 33682.0 46393.0 54989.0 36505.0 55401.0 True False 44406.81663597351 43862.473606684194 43688.82321549449 43705.60131530658 41092.81670148925 38321.3897652464 48550.366425985514 55149.008886081014 43807.02003492201 53801.4291809152 0.8253835876115684 0.8152659562107577 0.8120383395129601 0.8123501918199995 0.7637867121207622 0.7122745686993761 0.9023991958044049 1.02504728453652 0.8142352480565986 1.0 15.715356876584748 -7.455892504726933 6.729825309266907 0.9444654434252022 0.7927299974055838 0.5894739684371362 0.060176393512516774 0.16841104947969404 14.139709110315755 0.024881272696108715 0.016536154591093925 3.500317951314526e-08 7.455892504726933 -0.15173544601961841 ADVVPQQADPEFPRAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ADVVPQQADPEFPRASPR 18 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 ADVVPQQADPEFPRAS(1)PR;ADVVPQQADPEFPRAS(1)PR 160.98 6.3329999999999985e-06 134525000.0 10981.2 12170.9 14985.2 15648.7 12594.7 11312.8 11590.6 9911.0 6621.2 8578.0 True False 11237.040594304375 10745.92536990209 12950.292147811559 12915.948307479883 11455.511608774888 11199.003503200562 10716.311710354401 9648.128084534877 11235.692806685547 9679.069856795699 1.1609628570264756 1.1102229376263204 1.337968662218005 1.3344204038791563 1.1835343455788725 1.157033027852125 1.107163381286111 0.9968032287483598 1.1608236093881417 1.0 13.240652698126425 -7.07370674033174 1.743355420858445 1.059850331220769 1.2328375030233427 0.48415496836421934 0.07864513379064246 0.34466353161367663 2.086525962575611 0.041001548332731605 0.029413925261265118 8.439044163741579e-08 7.07370674033174 0.17298717180257372 ADVVPQQADPEFPRAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 ADVVPQQADPEFPRASPR 18 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 ADVVPQQADPEFPRAS(1)PR;ADVVPQQADPEFPRAS(1)PR;ADVVPQQADPEFPRAS(1)PR;ADVVPQQADPEFPRAS(1)PR 106.31 0.00091827 189369000.0 678480.0 693420.0 777140.0 783990.0 827590.0 562160.0 511630.0 502912.0 449964.0 746510.0 True False 640772.7977706365 746603.084303279 727139.6584860542 677209.2095418157 723620.7454515286 639592.4372196101 535421.8087756124 504375.39065843704 539969.3730446158 724956.3166340877 0.8838778048664941 1.0298594096947737 1.0030116874656718 0.9341379528714807 0.9981577218490073 0.8822496232451424 0.7385573399257097 0.6957321139019939 0.744830220325066 1.0 19.46753454035877 -7.027766498116075 3.5428539551403238 0.7706861725761066 0.9722926277750625 0.467353767689201 0.08632779524648708 0.17904975871761972 4.706448048752242 0.03245563482108472 0.025982229676611828 9.380662301368532e-08 7.027766498116075 0.20160645519895593 ADYDTLS(ph)LR ddPTM_A459_Selumetinib_30min_R1 3 ADYDTLSLR 9 0 Q9Y446;Q9Y446-2;E9PKC4;E9PK71;E9PJR7;E9PRW6;E9PQ15 Q9Y446 PKP3 Plakophilin-3 1 ADYDTLS(1)LR;ADYDTLS(1)LR;ADYDTLS(1)LR 135.8 0.0026956 52882100.0 17398.9 14709.9 14395.3 15301.8 14326.7 15095.199999999999 15416.5 14301.2 10251.800000000001 12752.6 True False 17804.26051763399 12987.658069553016 12440.497327722807 12629.627880360387 13030.85251458432 14943.355993344978 14253.620993104641 13921.8857191555 17396.555838153035 14389.520430843177 1.2373074282219647 0.9025775481519632 0.8645526018405213 0.8776962332455116 0.9055793469428888 1.038488813102811 0.9905556659520603 0.9675017166878386 1.2089739836544127 1.0 13.812730890767797 -8.178884529950277 10.879773714844502 1.1043318423762591 0.964300051060484 0.17522737799207866 0.11281711047884463 0.9390634583699221 120.08527418903084 0.07612531786236972 0.028734220549353717 6.623925969797e-09 8.178884529950277 -0.14003179131577514 ADYDTLS(ph)LR ddPTM_A459_Selumetinib_30min_R2 2 ADYDTLSLR 9 0 Q9Y446;Q9Y446-2;E9PKC4;E9PK71;E9PJR7;E9PRW6;E9PQ15 Q9Y446 PKP3 Plakophilin-3 1 ADYDTLS(1)LR;ADYDTLS(1)LR 121.29 0.0063098 17195800.0 93267.0 66553.0 69712.0 90053.0 70215.0 83276.0 68063.0 78311.0 61399.0 65237.0 True False 88083.59351738279 71657.40109837623 65226.805816686756 77787.62604991018 61393.963969935685 94746.51309573837 71228.06436427595 78538.87204491599 73680.5156313979 63353.4383039181 1.390352218846112 1.1310735931114344 1.0295701001069866 1.227835901766667 0.969070749963365 1.4955228261049056 1.124296743336673 1.2396939163451646 1.1630073695122736 1.0 15.951135298669342 -8.562096261722116 18.4430340993227 0.9999999952222501 1.1938225021820075 0.14007390867263958 0.14804444316001825 909.3810932465715 427662.0571070123 0.1375856140586337 0.03552445279862135 2.7409665671424815e-09 8.562096261722116 0.19382250695975733 AEADKIYSFTDNAPS(ph)PSIGGSSR ddPTM_A459_Selumetinib_30min_R1 2 AEADKIYSFTDNAPSPSIGGSSR 23 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 AEADKIYSFTDNAPS(0.821)PS(0.167)IGGS(0.007)S(0.004)R;AEADKIYSFTDNAPS(0.871)PS(0.121)IGGS(0.006)S(0.002)R 144.23 3.3450000000000004e-07 24071000.0 3641.8999999999996 3499.6000000000004 4973.799999999999 5288.1 4915.799999999999 3814.0 3516.6 3595.3 2111.63 2743.3 True False 3726.7491840961943 3089.8652050801 4298.38527912775 4364.632604931038 4471.16675795498 3775.6346228349234 3251.340030769096 3499.9409648197184 3583.281882646862 3095.4292770048537 1.2039522956577473 0.9982024877886606 1.388623319892768 1.4100249801714964 1.4444415807429767 1.219745077325184 1.0503680555464352 1.1306803197927595 1.157604184100131 1.0 11.59592378226332 -7.068483834510728 5.386243308636136 1.0982235766751411 1.2894438467336053 0.36954398441184355 0.12543380672143112 0.2900791861557947 15.99764486722197 0.05385119381117756 0.04199805668269057 8.541146390360871e-08 7.068483834510728 0.1912202700584642 AEADKIYSFTDNAPS(ph)PSIGGSSR ddPTM_A459_Selumetinib_30min_R2 2 AEADKIYSFTDNAPSPSIGGSSR 23 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 AEADKIYSFTDNAPS(0.878)PS(0.121)IGGSSR;AEADKIYSFTDNAPS(0.879)PS(0.12)IGGS(0.001)SR 130.62 4.2829e-06 30994000.0 89780.0 99078.0 90405.0 119274.0 121600.0 72120.0 69841.0 62102.0 53581.0 114669.0 True False 84790.38701781578 106676.96401401791 84588.44072552168 103028.67544087365 106323.52088220707 82053.87535982339 73088.74488731606 62282.70653846042 64298.69717822647 111358.2080241581 0.7614201819718697 0.9579622904031947 0.7596066982971836 0.9252005511665791 0.9547883606311373 0.7368462263870355 0.6563390897190098 0.5593005459009253 0.5774042014422276 1.0 16.764848375080007 -6.950146640637687 5.042694782876413 0.6653554166442565 0.8727627070962164 0.2738689968585929 0.1316218051944208 0.21446289947252176 11.971690460023135 0.045678694827618826 0.039605461654494994 1.1216396658668381e-07 6.950146640637687 0.20740729045195994 AEAES(ph)DALPDDTVIESEALPSDIAAEAR ddPTM_A459_Selumetinib_30min_R1 2 AEAESDALPDDTVIESEALPSDIAAEAR 28 0 G3V529;Q9GZR7-2;Q9GZR7;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AEAES(1)DALPDDTVIESEALPSDIAAEAR;AEAES(1)DALPDDTVIESEALPSDIAAEAR 156.52 2.3328e-17 3944300.0 1181.85 1997.3600000000001 1177.67 1381.55 1276.35 1347.02 1477.12 1330.52 549.05 1359.42 True False 1209.3848055202193 1763.5081626525268 1017.7488824782611 1140.2882274053964 1160.9043678578946 1333.4702017963039 1365.6996491638645 1295.230287461945 931.6977489746108 1533.914798872139 0.7884302351144007 1.1496780420589225 0.6634976618170672 0.7433843315442491 0.7568245437826713 0.8693248169825217 0.8903360539764267 0.8443951961440788 0.6073986310450046 1.0 10.583002635391885 -5.271685935361184 24.998997455693136 0.7939195994647299 0.9690541522741464 0.20738010071498547 0.13452837248712948 906.0483350779291 2210530.3685569093 0.03379980796649439 0.0716106993451162 5.349510750680103e-06 5.271685935361184 0.17513455280941648 AEAGAGS(ph)ATEFQFR ddPTM_A459_Selumetinib_30min_R1 2 AEAGAGSATEFQFR 14 0 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 AEAGAGS(0.512)AT(0.488)EFQFR;AEAGAGS(0.5)AT(0.5)EFQFR 217.39 1.1915e-08 56768000.0 2040.3999999999999 2112.31 1855.49 2005.12 2094.45 1753.95 1959.05 1525.4299999999998 846.41 1817.66 True False 2087.9373500727293 1864.9997632137229 1603.524649477008 1654.9634327640026 1905.0073673051816 1736.3068554591819 1811.2772812597952 1484.9706411050374 1436.2959506595034 2050.974366507726 1.0180221577454143 0.9093237797941526 0.7818355390795996 0.8069157078652199 0.9288304127120379 0.8465765754135969 0.8831301408919742 0.7240317896481344 0.7002993182723881 1.0 11.002093745498241 -7.7381171230539545 24.68351513253901 0.7841241585162363 0.8768225277060746 0.09084784772678367 0.09787883692952558 361.3739205118956 382466.99074686697 0.04566923075001279 0.026345058269485553 1.8276072699502606e-08 7.7381171230539545 0.09269836918983831 AEAGAGS(ph)ATEFQFR ddPTM_A459_Selumetinib_30min_R2 4 AEAGAGSATEFQFR 14 0 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 AEAGAGS(0.939)AT(0.061)EFQFR;AEAGAGS(0.979)AT(0.021)EFQFR;AEAGAGS(0.987)AT(0.013)EFQFR;AEAGAGS(0.986)AT(0.014)EFQFR 120.92 0.0019956 56821500.0 64867.5 62656.9 70201.9 70375.9 76323.4 70845.6 72912.8 70857.5 59063.5 56083.8 True False 61262.42403517677 67462.48275631231 65685.18618404945 60790.58101480097 66734.97215214679 80603.93832767471 76303.38967397221 71063.68359390942 70877.85037207548 54464.51497078779 1.1248135426898607 1.2386502072495462 1.206018014101106 1.1161502318969734 1.2252926917267195 1.4799349332479483 1.4009743723027326 1.3047703377515552 1.3013583323029871 1.0 15.73302896266513 -6.535934407964369 24.999486087866956 1.3262270358934658 1.1776879276167094 0.17429796257830288 0.12158033771338218 319.5193073751495 611823.8338915268 0.03839063222026962 0.038409821886326134 2.9111567604913507e-07 6.535934407964369 -0.14853910827675643 AEAPAGPALGLPS(ph)PEAESGVDR ddPTM_A459_Selumetinib_30min_R1 5 AEAPAGPALGLPSPEAESGVDR 22 0 Q53F19 Q53F19 C17orf85 Uncharacterized protein C17orf85 1 AEAPAGPALGLPS(0.984)PEAES(0.016)GVDR;AEAPAGPALGLPS(0.987)PEAES(0.013)GVDR;AEAPAGPALGLPS(0.998)PEAES(0.002)GVDR;AEAPAGPALGLPS(0.996)PEAES(0.004)GVDR;AEAPAGPALGLPS(0.994)PEAES(0.006)GVDR 188.26 1.195e-21 168753000.0 11204.63 11129.349999999999 6820.219999999999 6579.87 9254.9 7790.17 10906.019999999999 10564.9 5941.120000000001 10292.38 True False 11465.67607858528 9826.320528105554 5894.071584786815 5430.819223957114 8417.795929085301 7711.807962708426 10083.370130912925 10284.684532368323 10081.646717763488 11613.507229271032 0.9872707574234635 0.8461113713641131 0.50751865637378 0.46762955554624486 0.7248280612310497 0.6640378148016608 0.8682450470688559 0.8855795522688009 0.8680966497660072 1.0 13.503516105256058 -7.338280830909957 4.121220796487255 0.9023254776480949 0.687819426388184 0.3270169584972664 0.1446020126616921 0.3176344141083445 10.250204058069407 0.07004474780579983 0.04631946829220798 4.589011743644357e-08 7.338280830909957 -0.21450605125991085 AEAPAGPALGLPS(ph)PEAESGVDR ddPTM_A459_Selumetinib_30min_R2 6 AEAPAGPALGLPSPEAESGVDR 22 0 Q53F19 Q53F19 C17orf85 Uncharacterized protein C17orf85 1 AEAPAGPALGLPS(0.855)PEAES(0.145)GVDR;AEAPAGPALGLPS(0.998)PEAES(0.002)GVDR;AEAPAGPALGLPS(0.989)PEAES(0.011)GVDR;AEAPAGPALGLPS(1)PEAESGVDR;AEAPAGPALGLPS(0.992)PEAES(0.008)GVDR;AEAPAGPALGLPS(0.998)PEAES(0.002)GVDR 230.39 1.6007e-30 134595000.0 95728.6 60927.9 88548.3 102338.7 113556.5 94723.70000000001 114550.7 114676.5 103712.0 76271.5 True False 90408.38764394849 65600.87401592353 82851.19878209932 88399.99251589547 99290.51726200953 107771.02985886445 119877.53452790595 115010.18962928343 124457.29795539874 74069.34361784399 1.2205911815609538 0.8856683590229585 1.1185626162635482 1.1934761157327052 1.3405075894055787 1.4550018211974733 1.618450072224298 1.5527367195620243 1.680280827079124 1.0 16.1765889320412 -6.295911562716256 1.456090794654383 1.509688392154095 1.0522634802770001 0.4371311193217746 0.19089054833739794 0.32238848488576877 1.3717900520036987 0.06906527610089502 0.09269001199521656 5.059276757783221e-07 6.295911562716256 -0.4574249118770948 AEAPAGPALGLPS(ph)PEAESGVDRGEPEPMEVEEGELEIVPVRR ddPTM_A459_Selumetinib_30min_R2 2 AEAPAGPALGLPSPEAESGVDRGEPEPMEVEEGELEIVPVRR 42 2 Q53F19 Q53F19 C17orf85 Uncharacterized protein C17orf85 1 AEAPAGPALGLPS(0.529)PEAES(0.471)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.79)PEAES(0.21)GVDRGEPEPMEVEEGELEIVPVRR 71.811 1.8291e-08 16812900.0 13624.1 18898.7 19891.1 21169.4 17636.3 12798.9 8739.5 10028.7 5485.1 18729.8 True False 12866.927063593514 20348.169521101758 18611.328281792183 18286.0912007481 15420.670323477549 14561.832298153677 9145.904066990715 10057.881856659344 6582.273266499131 18189.02200813535 0.7074007089462292 1.118706080623834 1.0232176459772244 1.0053366911409163 0.8478009601934832 0.8005835768212634 0.5028254989685567 0.5529644118392283 0.3618816483676306 1.0 14.150780353437998 -6.9176735352342575 1.9223223345791711 0.5677033238529315 0.9713325363809876 0.414790291916725 0.18503922612873042 0.2817820232730474 2.122161145087525 0.07670749021291483 0.06285517366495567 1.2087221056876231e-07 6.9176735352342575 0.40362921252805606 AEAPAGPALGLPSPEAES(ph)GVDRGEPEPMEVEEGELEIVPVRR ddPTM_A459_Selumetinib_30min_R1 8 AEAPAGPALGLPSPEAESGVDRGEPEPMEVEEGELEIVPVRR 42 2 Q53F19 Q53F19 C17orf85 Uncharacterized protein C17orf85 1 AEAPAGPALGLPS(0.124)PEAES(0.876)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.109)PEAES(0.891)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.135)PEAES(0.865)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.099)PEAES(0.901)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.003)PEAES(0.997)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.372)PEAES(0.628)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.305)PEAES(0.695)GVDRGEPEPMEVEEGELEIVPVRR;AEAPAGPALGLPS(0.111)PEAES(0.889)GVDRGEPEPMEVEEGELEIVPVRR 72.811 1.1988e-08 191942600.0 3761.46 4008.1600000000008 6038.929999999999 5994.3 5496.96 4416.24 4359.68 3899.77 2203.49 2892.9 True False 3849.094699472932 3538.8827638569696 5218.876475468039 4947.508031946847 4999.760938567109 4371.816635225095 4030.8258276014944 3796.3354313617765 3739.1615934579104 3264.2318942322545 1.1791731789258302 1.0841395092395274 1.5988068999293679 1.5156729645001212 1.531680683410224 1.339309453764572 1.2348466525076773 1.163010335775998 1.1454950857090866 1.0 11.672527836081523 -7.686038028894617 1.4079863949466767 1.072055907530449 1.3858950176773888 0.403885631049164 0.15145032638368935 0.5077618273209767 1.885070733810923 0.1329092015307861 0.05457394466487929 2.060449482593944e-08 7.686038028894617 0.31383911014693977 AEAPLPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AEAPLPSPK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 AEAPLPS(1)PK;AEAPLPS(1)PK 103.43 0.015244 272740000.0 24469.0 22207.0 24410.0 22703.0 18223.5 22307.0 24000.0 30388.0 24979.0 18145.0 True False 25039.080091614192 19606.994116245784 21095.256074532226 18738.34723809106 16575.18764262025 22082.611833135477 22189.660677489144 29582.01152586479 42387.538606022805 20474.08749726719 1.22296439804491 0.9576492294888773 1.0303392557713718 0.915222582720338 0.8095690538019166 1.0785639084566276 1.0837924122601772 1.4448512799319282 2.070301722197902 1.0 14.321511533857565 -7.785864262354306 3.4353295505974804 1.5967698703147506 0.996630232956544 0.4229932475289353 0.2622855558965137 0.19064029118318288 4.6505866957673225 0.14562280501607305 0.06785371794898239 1.6373281842613368e-08 7.785864262354306 -0.6001396373582066 AEAPLPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 AEAPLPSPK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 AEAPLPS(1)PK;AEAPLPS(1)PK;AEAPLPS(1)PK;AEAPLPS(1)PK 124.39 0.005326300000000001 264263000.0 902300.0 844930.0 756270.0 746870.0 604550.0 542780.0 886800.0 827290.0 730660.0 1044170.0 True False 852153.7781930852 909733.414121843 707612.4115645165 645145.0175773873 528601.0242544267 617543.0181337352 928037.9571608626 829697.2769347674 876812.4163461468 1014022.099020527 0.8403700264680671 0.8971534397530198 0.6978274065703495 0.6362238241164087 0.5212914242845571 0.6090035106041946 0.9152048639347024 0.8182240581701284 0.8646876800743151 1.0 19.951657663282695 -7.272750750073612 24.850275526336418 0.8843811668001841 0.6980956808461851 0.43602925453120756 0.1104417327038392 830.4839233449817 1824506.39543092 0.052583690502658 0.03581110988547484 5.336410744580526e-08 7.272750750073612 -0.18628548595399896 AEAPPLEREDS(ph)GTFSLGK ddPTM_A459_Selumetinib_30min_R1 4 AEAPPLEREDSGTFSLGK 18 1 G5E9Q4;O75569 G5E9Q4 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 1 AEAPPLEREDS(0.872)GT(0.119)FS(0.008)LGK;AEAPPLEREDS(0.632)GT(0.312)FS(0.056)LGK;AEAPPLEREDS(0.629)GT(0.282)FS(0.09)LGK;AEAPPLEREDS(0.822)GT(0.142)FS(0.036)LGK 100.76 0.0014892000000000002 70799400.0 11856.499999999998 9237.5 13165.8 15202.399999999998 13368.5 11646.5 10461.2 10709.199999999999 5670.4400000000005 9556.2 True False 12132.733381267062 8155.969205602761 11377.956674562733 12547.586224391303 12159.321535400368 11529.346784175917 9672.103261639559 10425.15722761587 9622.322527448498 10782.83135527059 1.125189941446747 0.7563847506171157 1.0551919342595717 1.1636634025865675 1.1276557274038193 1.0692318561154566 0.8969910539231319 0.966829294100024 0.8923743876180683 1.0 13.396448430169551 -7.256360935849832 24.150861463563807 0.9362844571600737 1.0452203962109583 0.19579514599546166 0.1094468818216265 502.4791131535823 2389579.638167112 0.04562463205435817 0.034203171285915455 5.541649630536714e-08 7.256360935849832 0.10893593905088461 AEAPPLEREDS(ph)GTFSLGK ddPTM_A459_Selumetinib_30min_R2 2 AEAPPLEREDSGTFSLGK 18 1 G5E9Q4;O75569 G5E9Q4 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 1 AEAPPLEREDS(0.902)GT(0.07)FS(0.028)LGK;AEAPPLEREDS(0.852)GT(0.146)FS(0.002)LGK 100.47 0.0015286 42501000.0 104093.0 99073.0 96518.0 121892.0 94208.0 70222.0 42435.0 44773.0 38292.0 97449.0 True False 98307.92777729465 106671.58053009544 90308.13696085263 105290.09932457177 82372.74880979415 79894.44308815185 44408.3115833573 44903.282017430814 45951.46996787383 94635.39416709109 1.0388071888168948 1.1271848283502988 0.9542744314183537 1.112586894694689 0.870422208675481 0.8442342718738808 0.4692568987978077 0.4744871875119814 0.4855632543437241 1.0 16.530092240061542 -6.868818987005641 1.825100506174759 0.567081927817868 1.0487813310909153 0.5920467618978864 0.16063666350684608 0.21108800133509928 1.4435063970806197 0.06619712342025677 0.05592403354200301 1.3526362215520385e-07 6.868818987005641 0.4816994032730473 AEAPS(ph)SPDVAPAGKEDS(ph)PSASGR ddPTM_A459_Selumetinib_30min_R1 1 AEAPSSPDVAPAGKEDSPSASGR 23 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 2 AEAPS(0.5)S(0.5)PDVAPAGKEDS(0.862)PS(0.131)AS(0.007)GR 97.877 0.00012433 5961200.0 3001.1 2888.0 2894.7 2756.8 2712.1 3003.8 2891.7 2698.4 1652.9 2823.9 True False 3071.0197908759387 2549.871617405224 2501.6156394489317 2275.3766315451476 2466.791033860144 2973.5844992321854 2673.5767408789725 2626.8296663615083 2804.8505769604503 3186.3750721153383 0.9637973312530284 0.800242143406062 0.7850976683006073 0.7140956667209281 0.7741684447156172 0.9332186048198376 0.8390652953181891 0.8243943688078238 0.8802637836036028 1.0 11.637700382922638 -6.749835195164021 24.999495790322875 0.8808928687431662 0.8006466197911164 0.24062004028791562 0.07544453364972195 367.45311703427626 791622.1603732589 0.025588677252978177 0.025379724977194755 1.778954354511509e-07 6.749835195164021 -0.08024624895204979 AEAPS(ph)SPDVAPAGKEDS(ph)PSASGR ddPTM_A459_Selumetinib_30min_R2 2 AEAPSSPDVAPAGKEDSPSASGR 23 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 2 AEAPS(0.5)S(0.5)PDVAPAGKEDS(0.845)PS(0.145)AS(0.01)GR;AEAPS(0.745)S(0.255)PDVAPAGKEDS(0.897)PS(0.102)AS(0.001)GR 158.14 3.1889e-09 42384000.0 191238.0 178866.0 172573.0 183171.0 182816.0 137606.0 153813.0 148127.0 112626.0 181845.0 True False 180609.75754636948 192584.44705516126 161469.84106327585 158222.7938124005 159849.01968422378 156559.97743710293 160965.60927467735 148558.02504625518 135154.34703336892 176594.66235994914 1.0227362205219797 1.0905451188701303 0.9143528966586505 0.8959658898970476 0.9051746952487552 0.8865498840389074 0.9114975907175754 0.8412373458007044 0.7653365352452538 1.0 17.43008221208227 -5.364167794448489 4.333000783881975 0.8832566782469166 1.0561848291470715 0.5726122482293304 0.057764819019711824 0.1463231789220093 4.601991459932352 0.015274001600256616 0.03398667377163575 4.3234675683811685e-06 5.364167794448489 0.1729281509001549 AEAPS(ph)SPDVAPAGKEDSPSASGR ddPTM_A459_Selumetinib_30min_R1 2 AEAPSSPDVAPAGKEDSPSASGR 23 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 AEAPS(0.5)S(0.5)PDVAPAGKEDSPSASGR;AEAPS(0.5)S(0.5)PDVAPAGKEDSPSASGR 109.42 9.271e-06 18744600.0 3862.0 4455.0 3736.9 3658.3 4019.0 3274.0 3576.5 3560.8999999999996 1976.04 2866.7 True False 3951.977085856147 3933.4065289266887 3229.449505322386 3019.446579795999 3655.482159612081 3241.066532554153 3306.7217255433306 3466.4533645666684 3353.19555574864 3234.668869022641 1.221756305167101 1.216015205326155 0.9983864302926834 0.9334638882861379 1.1300947044748322 1.0019778418720942 1.0222751877976495 1.0716563286473466 1.0366426028522084 1.0 11.659402316672734 -5.255680666347871 24.536667044148604 1.0265342449097217 1.2188857928234729 0.7189929400730373 0.04864056543795187 185.22433221386297 789194.5012858205 0.012565994880925822 0.03135606388406828 5.550336752782545e-06 5.255680666347871 0.1923515479137512 AEAPSS(ph)PDVAPAGK ddPTM_A459_Selumetinib_30min_R1 4 AEAPSSPDVAPAGK 14 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 AEAPS(0.016)S(0.984)PDVAPAGK;AEAPS(0.044)S(0.956)PDVAPAGK;AEAPS(0.48)S(0.52)PDVAPAGK;AEAPS(0.006)S(0.994)PDVAPAGK 253.06 9.7811e-28 118354000.0 31024.600000000002 36881.2 16263.2 16521.1 24006.5 21618.5 32640.5 30172.199999999997 15278.9 29264.1 True False 31747.412816637123 32563.13195839529 14054.746767363062 13636.000024456072 21835.116313691826 21401.03751802749 30178.4008059827 29371.935242881977 25927.177373296043 33020.43229147296 0.9614475224431095 0.9861509889076844 0.4256378790956197 0.41295643570291385 0.6612607648789148 0.6481150013155338 0.913931124208081 0.8895078957057401 0.7851858856490912 1.0 15.011071387162275 -7.2610120739669295 24.50243804121768 0.8879485587674999 0.6714868972099103 0.24629178511968441 0.18297935386676595 49.38648413432937 2832048.911649655 0.08153794467503604 0.059220852679128355 5.4826172230046915e-08 7.2610120739669295 -0.2164616615575896 AEAPSS(ph)PDVAPAGK ddPTM_A459_Selumetinib_30min_R2 2 AEAPSSPDVAPAGK 14 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 AEAPS(0.018)S(0.982)PDVAPAGK;AEAPS(0.056)S(0.944)PDVAPAGK 252.2 1.227e-27 150378000.0 1267980.0 955060.0 1116000.0 1287640.0 1313760.0 1205100.0 1348110.0 1521330.0 1415450.0 1057290.0 True False 1197510.747726109 1028310.030998081 1044197.7750089255 1112261.2106971028 1148713.7236365844 1371091.5861913909 1410799.7862292866 1525756.818430262 1698579.550977409 1026763.2905306738 1.1662968074240228 1.0015064236145488 1.0169800426632323 1.0832693581421675 1.1187717112898354 1.3353531420886249 1.3740263206139038 1.4859869187976984 1.6543049080957235 1.0 19.969672191156455 -6.800440498547442 1.9702841990161963 1.4207501878627333 1.0572014557805647 0.45223451420396144 0.1596738812261728 0.2641090886192726 2.1110600409705804 0.06290546125823383 0.056173051576992886 1.583286473426719e-07 6.800440498547442 -0.36354873208216865 AEAPSS(ph)PDVAPAGKEDS(ph)PSASGR ddPTM_A459_Selumetinib_30min_R1 1 AEAPSSPDVAPAGKEDSPSASGR 23 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 2 AEAPS(0.334)S(0.665)PDVAPAGKEDS(0.83)PS(0.158)AS(0.013)GR 79.78399999999998 0.0012049 3894100.0 1884.9 1912.7 1497.8 1555.5 1241.1 1467.2 1531.5 1498.8 919.07 1347.4 True False 1928.8145026230568 1688.760194809894 1294.4069868264799 1283.8611253513043 1128.8427241340012 1452.4413001110129 1415.9777219822763 1459.0469552114698 1559.5946637830725 1520.3519147874247 1.2686631850578773 1.1107692754450316 0.8513864285213621 0.8444499677108069 0.7424877840153448 0.9553323056222105 0.9313486622472259 0.9596771254209743 1.025811622042213 1.0 10.570189586590788 -5.03338928895701 3.205582303357304 0.9064398643235234 1.257831497191318 0.6734584630523144 0.08008902706565198 0.15166270069681523 3.0232341611303837 0.02264994923018725 0.09746706389460406 9.259994122845395e-06 5.03338928895701 0.3513916328677946 AEAPSS(ph)PDVAPAGKEDS(ph)PSASGR ddPTM_A459_Selumetinib_30min_R2 2 AEAPSSPDVAPAGKEDSPSASGR 23 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 2 AEAPS(0.379)S(0.621)PDVAPAGKEDS(0.796)PS(0.192)AS(0.012)GR;AEAPS(0.476)S(0.524)PDVAPAGKEDS(0.834)PS(0.156)AS(0.01)GR 105.75 4.153100000000001e-05 13269200.0 92566.0 79164.0 93319.0 91568.0 97679.0 69644.0 70503.0 76944.0 53458.0 83334.0 True False 87421.5522910576 85235.62424762028 87314.95713804472 79096.28043638934 85407.69075866051 79236.82883471344 73781.5291990442 77167.89430123514 64151.0937413193 80927.93089226515 1.0802395579276214 1.053228759315368 1.0789223964502719 0.9773668937821456 1.0553549289720383 0.9791036044180719 0.9116942492606841 0.9535384563824381 0.792694104915645 1.0 16.30435008968631 -6.998842454665651 1.1865709376777651 0.9006645130823108 1.0555166263349798 0.55821018744337 0.056028717512057076 0.3352168137519697 0.9676193389747986 0.0308883530466903 0.02227234289745942 1.0026689018255768e-07 6.998842454665651 0.154852113252669 AEAPSS(ph)PDVAPAGKEDSPSASGR ddPTM_A459_Selumetinib_30min_R2 1 AEAPSSPDVAPAGKEDSPSASGR 23 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 AEAPS(0.312)S(0.688)PDVAPAGKEDSPSASGR 142.23 9.5574e-07 28460000.0 129560.0 142980.0 154190.0 152020.0 149450.0 92198.0 75983.0 89228.0 56262.0 130420.0 True False 122359.57386977292 153946.10624683843 144269.58326937832 131314.6137508725 130674.75490004824 104897.43760988627 79516.36005745818 89487.63870750932 67515.9720916254 126654.43572814522 0.9660899214963863 1.215481363615822 1.1390803838804568 1.036794431998655 1.0317424269334896 0.8282176380702623 0.6278213597519349 0.7065495826738213 0.5330723057859865 1.0 16.950538078853477 -6.8202455185101 2.1351730396527313 0.6912155791378553 1.099762569249507 0.644470798098874 0.12756364953641994 0.17582905309855035 1.6453958349324267 0.04895592155105561 0.04333883160792516 1.5127058328183206e-07 6.8202455185101 0.40854699011165174 AEASPNDT(ph)AGAR ddPTM_A459_Selumetinib_30min_R2 1 AEASPNDTAGAR 12 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 AEAS(0.162)PNDT(0.838)AGAR 115.37 0.0099023 0.0 70818.0 51220.0 59857.0 67744.0 73382.0 57508.0 54764.0 64622.0 46605.0 68969.0 True False 66882.21906691566 55148.409301741965 56005.865787373994 58517.1503350817 64163.097116596386 65429.20499435281 57310.63451280733 64810.039321251985 55927.30225250083 66977.68576701754 0.9985746491684714 0.8233848134672223 0.8361869351860093 0.8736812815335859 0.9579772185588538 0.9768806468164467 0.8556675832629224 0.9676362892963228 0.8350139544540914 1.0 16.031392908025744 -6.239897764543434 22.65169757300243 0.9289855775728595 0.8753610298454556 0.11318402668160676 0.06580131384001073 511.7502835528548 538118.857084084 0.01886589401769325 0.02432062901543117 5.755754152034913e-07 6.239897764543434 -0.05362454772740388 AEASS(ph)PVPY(ph)LSPETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R1 1 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 2 AEAS(0.099)S(0.582)PVPY(0.734)LS(0.36)PET(0.224)NPASSTSAVNHNVNLTNVR 124.17 1.8613000000000003e-18 6986100.0 278.04 169.78 234.85 415.99 213.06 151.3 297.62 136.65 0.0 221.6 True False 284.5177910283385 149.90207867141933 202.9586599387092 343.3451555994144 193.78876061879822 149.77805936940857 275.17028378476346 133.02559809824345 0.0 250.04451856679032 1.1378685390071444 0.5995015588849169 0.8116900986353602 1.373136102192547 0.7750170318852024 0.5990055699997311 1.1004851670494096 0.532007655519593 0.0 1.0 7.966041168652695 -7.900354087650589 6.346779811318628 0.42548101147180845 0.896548199975032 0.23994744268831114 0.3221691433852221 0.260543990617065 13.967466744255633 0.17372577336599776 0.08225383181717287 1.2578994068887866e-08 7.900354087650589 0.47106718850322354 AEASS(ph)PVPYLS(ph)PETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R1 2 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 2 AEAS(0.197)S(0.79)PVPY(0.076)LS(0.873)PET(0.062)NPAS(0.002)STSAVNHNVNLTNVR;AEAS(0.163)S(0.749)PVPY(0.442)LS(0.567)PET(0.078)NPASSTSAVNHNVNLTNVR 164.69 1.2791999999999999e-30 21203600.0 2629.8599999999997 2674.76 2994.0600000000004 2987.66 3488.8 2675.42 3421.57 2349.77 885.5699999999999 1571.1100000000001 True False 2691.130621183232 2361.5978557378107 2587.4830971943447 2465.921266324062 3173.2386559976694 2648.507703886999 3163.47822017819 2287.4464664713464 1502.7476105262663 1772.7772724073552 1.518030867763096 1.3321458326972246 1.4595646827537754 1.3909932763157815 1.7899815760208546 1.4939878489588483 1.7844758444371993 1.2903180236314133 0.8476798715303924 1.0 10.791795575451435 -8.06305935572084 4.2750517415485225 0.9407310058632175 1.5312013583255566 0.7359437799431063 0.1459890843719319 0.11771634212007705 4.1839867127357 0.1079194580779756 0.03925374359864674 8.648497103060777e-09 8.06305935572084 0.5904703524623391 AEASS(ph)PVPYLS(ph)PETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R2 2 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 2 AEAS(0.175)S(0.818)PVPY(0.231)LS(0.466)PET(0.306)NPAS(0.002)S(0.001)TSAVNHNVNLTNVR;AEAS(0.224)S(0.767)PVPY(0.25)LS(0.374)PET(0.361)NPAS(0.017)S(0.006)T(0.001)S(0.001)AVNHNVNLTNVR 114.61 1.211e-15 22999000.0 71445.0 71834.0 100452.0 133273.0 134581.0 89441.0 87921.0 91561.0 86205.0 121820.0 True False 67474.37291699555 77343.43681728476 93989.0276838679 115120.98749125145 117673.73161059478 101760.68588544031 92009.5007121564 91827.42735126043 103448.40876894828 118302.74007362865 0.5703534244008313 0.6537755319035565 0.794478873653911 0.9731049967194593 0.994683060910995 0.8601718423605997 0.7777461507222233 0.7762071047053462 0.8744379775528833 1.0 16.852123963540173 -5.28066259728244 2.5397224509286236 0.8822761053222198 0.5879317225800422 0.6750578370529773 0.07746616310885768 0.19405614517639697 2.4004474543760352 0.023583956647918194 0.07486781273670357 5.240073790186757e-06 5.28066259728244 -0.29434438274217756 AEASS(ph)PVPYLSPETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R1 4 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.138)S(0.617)PVPY(0.087)LS(0.132)PET(0.027)NPASSTSAVNHNVNLTNVR;AEAS(0.163)S(0.558)PVPY(0.238)LS(0.021)PET(0.021)NPASSTSAVNHNVNLTNVR;AEAS(0.114)S(0.316)PVPY(0.208)LS(0.072)PET(0.289)NPAS(0.001)STSAVNHNVNLTNVR;AEAS(0.218)S(0.496)PVPY(0.073)LS(0.032)PET(0.014)NPAS(0.027)S(0.081)T(0.039)S(0.019)AVNHNVNLTNVR 130.84 3.8458e-25 659591200.0 7247.1 7930.7 7967.4 9043.2 9271.9 8379.5 8745.7 7033.6 3217.4300000000003 5282.200000000001 True False 7415.943329598155 7002.169957117594 6885.470841795498 7463.974881888082 8433.258282086897 8295.209837977258 8086.004807796535 6847.046079647309 5459.743718210334 5960.221822985106 1.2442394846781002 1.174817005990331 1.1552373462414176 1.2522981700284836 1.4149235603219883 1.3917619317434566 1.3566617229938525 1.1487904784419665 0.9160302888653038 1.0 12.54115030947122 -8.051634835473033 3.8145640864307846 0.9646365781711306 1.2824620524713255 0.7063306309333497 0.08356693078668671 0.14894718030775664 4.309243598920485 0.0714977613828506 0.025867284734511845 8.879022663715938e-09 8.051634835473033 0.3178254743001949 AEASS(ph)PVPYLSPETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R2 3 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.2)S(0.651)PVPY(0.083)LS(0.04)PET(0.025)NPASSTSAVNHNVNLTNVR;AEAS(0.127)S(0.412)PVPY(0.389)LS(0.036)PET(0.036)NPASSTSAVNHNVNLTNVR;AEAS(0.202)S(0.623)PVPY(0.075)LS(0.018)PET(0.082)NPASSTSAVNHNVNLTNVR 116.76 1.1195e-18 134075500.0 203730.0 180321.0 270899.0 360283.0 356254.0 214646.0 197426.0 232684.0 240942.0 270745.0 True False 192407.50219580767 194151.040876599 253469.65327253006 311211.8338771585 311498.187568831 244211.53813761284 206606.7001921976 233361.07191709004 289137.1324819671 262927.8883700098 0.7317881088560636 0.7384193517097609 0.9640272655893792 1.1836394982916394 1.1847285942161825 0.9288156522747483 0.7857922621789241 0.8875478115455318 1.099682252325679 1.0 18.00430764902584 -5.29024118291956 4.613441750091159 1.004450357771173 0.7313041216043545 0.4531945139335173 0.11888589998334302 0.19146781709188435 10.431700066047414 0.03595496697151438 0.08474626390040335 5.125766484692175e-06 5.29024118291956 -0.27314623616681843 AEASSPVPY(ph)LSPETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R1 1 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.067)S(0.178)PVPY(0.41)LS(0.172)PET(0.172)NPASSTSAVNHNVNLTNVR 75.26100000000002 7.8815e-05 398210000.0 615.28 707.78 608.2 645.24 432.87 568.09 711.83 430.08 201.76 487.56 True False 629.6148268735287 624.9127885620047 525.6097806034619 532.5609466548866 393.7169849294058 562.3755303844505 658.1360900023791 418.67288130327535 342.3719840326336 550.1430752365716 1.1444565154306139 1.1359095782370445 0.9554056103995131 0.9680408072497789 0.7156628932575408 1.0222350433887015 1.1962998711187423 0.761025449830916 0.622332624809296 1.0 9.103663057668388 -5.350323943638169 1.984436995270535 0.8971507991915498 1.1587848761111885 0.26987030709776416 0.15733909272505125 0.5381155644623143 3.9223868494009615 0.04815396041851134 0.16381365845066762 4.463505316105903e-06 5.350323943638169 0.2616340769196387 AEASSPVPYLS(ph)PETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R1 2 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.017)S(0.056)PVPY(0.31)LS(0.486)PET(0.131)NPASSTSAVNHNVNLTNVR;AEAS(0.001)S(0.002)PVPY(0.14)LS(0.717)PET(0.14)NPASSTSAVNHNVNLTNVR 138.78 9.4186e-26 182033000.0 4227.6 4319.5 4041.8 5143.700000000001 6271.299999999999 4004.8999999999996 5350.2 4156.3 1185.71 2809.5299999999997 True False 4326.094854522384 3813.7709319189275 3492.945760018204 4245.449354207333 5704.06202228794 3964.6143421582583 4946.630106529266 4046.0614224349033 2012.0632691679928 3170.1605426396854 1.3646295814786058 1.2030213866529704 1.101819833108435 1.3391906488976395 1.7992975262818582 1.250603648879264 1.5603721136502364 1.2762954329959217 0.6346881308076012 1.0 11.630340187552116 -8.15001289236386 5.5089772490682085 0.8243388694493374 1.3700356734798484 0.5425817072640088 0.2012034796105352 0.17070496825323672 6.99342947421686 0.1469982399016189 0.05341953815738432 7.079247687839994e-09 8.15001289236386 0.545696804030511 AEASSPVPYLS(ph)PETNPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R2 1 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.086)S(0.244)PVPY(0.263)LS(0.321)PET(0.086)NPASSTSAVNHNVNLTNVR 95.746 5.9172e-11 432140000.0 47514.0 38734.0 56513.0 54029.0 71683.0 39614.0 32750.0 57973.0 43563.0 63532.0 True False 44873.362093612195 41704.773250559825 52877.01510670205 46670.15699477641 62677.5406858492 45070.468919911866 34272.93989289387 58141.69183205319 52276.81725191916 61697.66608404014 0.7273105279620937 0.6759538228521087 0.8570342844845503 0.7564331028536098 1.0158818746964324 0.7305052489103899 0.5554981584912746 0.9423645256346771 0.8473062365229735 1.0 15.912928295299075 -14.522878743462599 0.16122361242423294 1.8075550892230017 0.7330909245787305 0.23229898007842298 0.12340560741914988 217.6022822183046 2.000454566219407 55.84411142805015 0.536694328964283 3.0000000125564965e-15 14.522878743462599 -1.0744641646442712 AEASSPVPYLSPET(ph)NPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R1 2 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.003)S(0.013)PVPY(0.034)LS(0.173)PET(0.777)NPASSTSAVNHNVNLTNVR;AEASSPVPY(0.016)LS(0.222)PET(0.76)NPASSTSAVNHNVNLTNVR 124.31 1.2902e-19 45477000.0 3120.6 3572.2 3821.0 4158.5 3685.3 3120.9 3678.7 3480.0 1795.5 2839.1 True False 3193.3039083694152 3153.9651633292756 3302.1291872506176 3432.296039712891 3351.9652656925614 3089.506579550476 3401.212697261639 3387.6990953669024 3046.8323618685286 3203.5261401758753 0.9968090687076776 0.9845292422543246 1.0307795356617033 1.0714119034859682 1.0463361680290633 0.964408106681115 1.06170905072587 1.0574906984155015 0.9510870923317192 1.0 11.645445047334773 -5.263574946190533 24.567995093045255 1.0268222718568183 0.9906691540795073 0.09325874726074057 0.0386891510582039 296.0493945288147 3405876.4738032133 0.010049091793037061 0.022824186623363434 5.4503583074974125e-06 5.263574946190533 -0.036153117777311006 AEASSPVPYLSPET(ph)NPASSTSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R2 2 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.093)S(0.28)PVPY(0.248)LS(0.089)PET(0.29)NPASSTSAVNHNVNLTNVR;AEAS(0.062)S(0.169)PVPY(0.13)LS(0.152)PET(0.178)NPAS(0.075)S(0.094)T(0.117)S(0.024)AVNHNVNLTNVR 79.054 9.4831e-06 397914000.0 397691.0 493933.0 756771.0 895729.0 965353.0 712824.0 600857.0 632473.0 599569.0 915503.0 True False 375588.9263032097 531816.0728550834 708081.1777699661 773729.1649812876 844076.7257746825 811009.0356279908 628798.041075559 634313.3917184577 719499.5533575721 889070.0496275397 0.42245144402351203 0.598171171189355 0.7964290081153945 0.8702679449222565 0.9493928247029507 0.9121992535545977 0.7072536537913777 0.7134571589541141 0.8092720631619452 1.0 19.761937567585115 -5.050530529611621 1.9842094683157407 0.8408319582461099 0.39899260390463154 0.7127965200283022 0.08877807237384466 0.2697362397688883 1.6798030285637386 0.02676239278230061 0.17875869553969367 8.901628600066715e-06 5.050530529611621 -0.44183935434147836 AEASSPVPYLSPETNPAS(ph)STSAVNHNVNLTNVR ddPTM_A459_Selumetinib_30min_R2 1 AEASSPVPYLSPETNPASSTSAVNHNVNLTNVR 33 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 AEAS(0.061)S(0.143)PVPY(0.146)LS(0.162)PET(0.162)NPAS(0.163)S(0.045)T(0.054)S(0.065)AVNHNVNLTNVR 68.942 0.00073822 15663000.0 52946.0 40273.0 68973.0 77962.0 82702.0 53856.0 39512.0 45086.0 56602.0 68451.0 True False 50003.47327963111 43361.8096018949 64535.352272124364 67343.44110804862 72312.23539473939 61274.17514390806 41349.38629154268 45217.19279561087 67923.98159201913 66474.64177294308 0.7522187701353484 0.6523060289667374 0.9708266272807797 1.0130696354569775 1.0878168496452485 0.9217676622192532 0.622032480186647 0.680217171384825 1.0218028977730569 1.0 16.02051647707367 -10.893208361872224 0.014354159947017766 1.8539876600602987 8.319089332956423e-06 0.058635011985841534 0.162184768499869 14732.950997112488 35.37290598226847 2514.0665326303056 2068.761585080752 1.2787676414059674e-11 10.893208361872224 -1.8539793409709657 AEDEALLS(ph)EEDDPIDR ddPTM_A459_Selumetinib_30min_R2 1 AEDEALLSEEDDPIDR 16 0 Q04721 Q04721 NOTCH2 Neurogenic locus notch homolog protein 2;Notch 2 extracellular truncation;Notch 2 intracellular domain 1 AEDEALLS(1)EEDDPIDR 99.747 0.0063838 3795200.0 12932.0 6300.4 11442.0 12096.0 9492.8 6631.5 15275.0 9819.2 11827.0 9557.4 True False 12213.29121089769 6783.620421020994 10705.834177107663 10448.503933236128 8300.229597291249 7544.92893023667 15985.31776683828 9847.77224634393 14192.730473990496 9281.453028892603 1.315881379012365 0.7308791414344277 1.1534653188224997 1.1257401077946056 0.894281269479373 0.8129038531736099 1.722286124497635 1.0610162240425511 1.5291496309693517 1.0 13.180134964312453 -7.237023130040742 24.99415824576334 1.3331978079637212 1.00017360205602 0.282818256691475 0.25152136005497555 946.0849331449718 968479.2105925855 0.09016284032172356 0.06980718350411676 5.793978375211683e-08 7.237023130040742 -0.3330242059077013 AEDEDIVLT(ph)PDGTR ddPTM_A459_Selumetinib_30min_R1 1 AEDEDIVLTPDGTR 14 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 AEDEDIVLT(0.997)PDGT(0.003)R 170.26 0.00038025 12970000.0 1498.4 1944.3 897.66 1188.0 1525.8 1251.2 1577.8 1504.7 722.04 1306.6 True False 1533.3098046211414 1716.6604521194515 775.7627024934287 980.5381015219223 1387.7916594018689 1238.614063998704 1458.785275705933 1464.7904680455679 1225.2491442849068 1474.3148373617698 1.040015175703543 1.164378468300129 0.5261852372601951 0.6650805354957682 0.9413129572006947 0.8401286025277727 0.9894665906750104 0.9935397995904013 0.8310634290823821 1.0 10.525828927004651 -7.253340605053145 23.291241581100298 0.9529791035320078 0.8558300008388191 0.060496860049115586 0.17371877980557815 812.0448905470566 2335363.7024378045 0.07316607938015487 0.0555394426467383 5.580323738421828e-08 7.253340605053145 -0.09714910269318866 AEDEDIVLT(ph)PDGTR ddPTM_A459_Selumetinib_30min_R2 2 AEDEDIVLTPDGTR 14 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 AEDEDIVLT(0.996)PDGT(0.004)R;AEDEDIVLT(0.993)PDGT(0.007)R 184.51 0.00018307 33181000.0 79796.0 60476.0 75291.0 76071.0 83634.0 80171.0 75475.0 69010.0 70404.0 65922.0 True False 75361.25776869718 65114.31473901112 70446.85903064256 65709.99857020541 73127.14922255355 91213.82753012209 78984.73705087519 69210.80767477945 84486.76725212048 64018.660574074325 1.1771764215763094 1.0171146061962517 1.1004113238066007 1.0264194530307937 1.1422786507371554 1.424800623945903 1.2337767823099643 1.0811036509377985 1.3197209453384775 1.0 15.966204872063129 -6.527406630942058 24.99438202048135 1.2255647584950649 1.0780993216987196 0.21543666501823722 0.11708128301251472 175.74254451811709 970105.0635843258 0.0374352364062313 0.03757359520559812 2.9688849560293976e-07 6.527406630942058 -0.14746543679634527 AEDGAT(ph)PSPSNET(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 2 AEDGAT(0.882)PS(0.119)PS(0.029)NET(0.97)PK 147.75 0.0026092 5775600.0 46082.0 34685.0 37829.0 39642.0 32787.0 33431.0 49396.0 41613.0 28751.0 33069.0 True False 43520.94692086198 37345.22797014685 35395.12332510097 34242.69121373569 28668.003940501043 38035.816793597565 51693.01187631708 41734.086940597015 34502.00337006008 32114.21204641948 1.3551927370335175 1.1628878801748646 1.1021638417887725 1.066278417924114 0.8926890032071434 1.1843920298781954 1.609661535571772 1.2995519516490857 1.0743531032363232 1.0 14.970924278495385 -7.005288586036916 24.971228291257333 1.2888789474149007 1.1073023397120187 0.07987609418482788 0.18568667638862554 431.2115279705308 2036067.367176849 0.0681796689167148 0.058420935273406145 9.878964253496797e-08 7.005288586036916 -0.18157660770288198 AEDGAT(ph)PSPSNETPK ddPTM_A459_Selumetinib_30min_R2 1 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.658)PS(0.338)PS(0.003)NETPK 123.1 0.0034655000000000003 5351200.0 19559.0 19305.0 17422.0 22974.0 22267.0 16433.0 19817.0 15900.0 16280.0 16767.0 True False 18471.989080880594 20785.631424641342 16301.087487639366 19844.901567639467 19469.620390494303 18696.49658607845 20738.529766640542 15946.266367613302 19536.454901206154 16282.8931441022 1.134441460581058 1.276531832561345 1.0011173900962285 1.2187577104396496 1.1957101369019525 1.1482293976025064 1.273639124393088 0.9793263535226953 1.199814721395652 1.0 13.991069439953083 -9.059279843362228 0.6130808857032051 0.997076506676121 1.1706177468111416 0.19574836342320512 0.09579896676450192 2.9402025127131246 1.8596873212690994 0.12184530175023907 0.038015369360749375 8.724090389952434e-10 9.059279843362228 0.1735412401350206 AEDGAT(ph)PSPSNETPKK ddPTM_A459_Selumetinib_30min_R1 1 AEDGATPSPSNETPKK 16 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.633)PS(0.348)PS(0.018)NETPKK 79.676 0.030341000000000007 9303400.0 3540.0 5953.8 4286.6 4801.7 4484.5 3681.0 4051.8 4253.8 2420.5 3594.0 True False 3622.4751123590786 5256.726328153472 3704.5032646083505 3963.173234072234 4078.8777668027824 3643.972482080588 3746.1694638771064 4140.975405710268 4107.4117136746145 4055.3249085245675 0.8932638429893474 1.2962528149356116 0.9134911130847331 0.977276376978174 1.0058078844012486 0.8985648657696234 0.9237655547653912 1.0211205018383749 1.0128440522831 1.0 11.98560179100081 AEDGATPS(ph)PSNETPK ddPTM_A459_Selumetinib_30min_R1 3 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.005)PS(0.758)PS(0.221)NET(0.016)PK;AEDGAT(0.185)PS(0.798)PS(0.017)NETPK;AEDGAT(0.001)PS(0.997)PS(0.001)NETPK 281.68 2.7832999999999995e-55 217578500.0 17218.899999999998 18578.6 18901.8 19185.600000000002 17939.3 16729.2 19055.1 18163.8 10063.3 15748.6 True False 17620.066867853027 16403.408875043187 16335.039380155384 15835.195118315654 16316.693482440658 16560.919436898286 17617.758465650975 17682.03701966246 17076.685105648306 17770.086214354484 0.9915577592200835 0.9230911250049362 0.9192436763171197 0.8911152668198173 0.9182112729008715 0.9319549290380231 0.9914278553932698 0.9950450890541601 0.9609793053144529 1.0 14.117163060393809 -7.227660563864417 5.67842797993687 0.9865560367174311 0.9259137280213585 0.5462676976394994 0.025663341707664024 0.15017652360722664 14.375224694276314 0.010465911053760114 0.007862868024118657 5.92024167994241e-08 7.227660563864417 -0.06064230869607257 AEDGATPS(ph)PSNETPK ddPTM_A459_Selumetinib_30min_R2 3 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.001)PS(0.996)PS(0.001)NET(0.003)PK;AEDGATPS(1)PSNETPK;AEDGAT(0.002)PS(0.94)PS(0.058)NETPK 276.34 3.4037999999999997e-46 244440000.0 684514.0 736461.6 734440.0 805926.0 740767.0 578711.0 698534.0 689929.9 569821.6 743273.0 True False 646471.4522066512 792945.8366227227 687186.9299978119 696157.4885001061 647705.2269189961 658423.1872345915 731017.2151188625 691937.481784956 683801.8421457696 721812.7772348223 0.8956220679318055 1.0985477974779037 0.952029323490701 0.9644571424282645 0.8973313404069636 0.9121800112169409 1.0127518356204517 0.9586107417434269 0.9473396200678686 1.0 19.461265155896065 -5.422708129364852 20.308716515262045 0.9528048761807241 1.004136986873843 0.07619144720782389 0.05607004815624726 17.67724248054031 3574.8550619481134 0.014050445542725854 0.02924828687907741 3.778260262356963e-06 5.422708129364852 0.05133211069311894 AEDGATPS(ph)PSNETPKK ddPTM_A459_Selumetinib_30min_R1 2 AEDGATPSPSNETPKK 16 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.004)PS(0.985)PS(0.011)NETPKK;AEDGAT(0.105)PS(0.81)PS(0.083)NET(0.002)PKK 222.45 9.4199e-11 12401000.0 3511.8999999999996 4185.8 4320.7 4304.4 4286.1 3794.0 3913.6 4171.6 2210.9300000000003 3474.7000000000003 True False 3593.7204370321588 3695.7245900743724 3733.9726719062396 3552.7173435950863 3898.423011772415 3755.83580467638 3618.3940011425616 4060.9556167334963 3751.7867300618136 3920.7115914441592 0.9165990288279389 0.9426157736619145 0.9523711665133889 0.9061409544501778 0.9943151697971402 0.9579474840415261 0.9228921630039506 1.0357700437837305 0.9569147443155532 1.0 11.936899805400403 -6.861471609472324 0.35819857902356916 1.002327073777956 0.9173556213537369 0.33309009399018197 0.031663709634608364 2.0028316197923144 0.5507170268758464 0.03612540218775436 0.06351330428679684 1.3757147400175395e-07 6.861471609472324 -0.084971452424219 AEDGATPS(ph)PSNETPKK ddPTM_A459_Selumetinib_30min_R2 1 AEDGATPSPSNETPKK 16 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.008)PS(0.835)PS(0.156)NET(0.001)PKK 89.557 0.006705199999999999 24480000.0 63759.0 92837.0 54468.0 72022.0 57977.0 42515.0 43903.0 66089.0 40739.0 55443.0 True False 60215.530027499706 99957.29938199556 50963.588180274426 62212.47935512005 50693.41093904381 48371.05533725582 45944.576492144115 66281.30804837713 48887.93834276644 53842.2165317861 1.1183701917611635 1.856485594774597 0.9465358498045441 1.155459105558786 0.9415179055475293 0.8983852904476853 0.8533188165650728 1.2310285927632183 0.9079852482281284 1.0 15.716450182395025 -5.288462528616679 24.946323902624684 0.9958000375531157 1.4874279632124408 0.4979820563345495 0.19902860984843013 468.5072212389249 432500.04525583365 0.04858580398754866 0.10118162777912396 5.146802122464655e-06 5.288462528616679 0.491627925659325 AEDGATPSPS(ph)NETPK ddPTM_A459_Selumetinib_30min_R2 1 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.005)PS(0.11)PS(0.806)NET(0.079)PK 105.63 0.0057131 725500000.0 160040.0 130490.0 124530.0 125830.0 111850.0 96443.0 123870.0 108500.0 73038.0 112790.0 True False 151145.6174908804 140498.16340851845 116517.87537801205 108691.73693114298 97798.40304831321 109727.14782761283 129630.2004437484 108815.71703685814 87647.64085222961 109533.45963638616 1.379903620251131 1.282696300061411 1.063765134095205 0.9923153828242309 0.8928632709399543 1.001768301593592 1.1834758152812537 0.9934472753630654 0.8001905640814229 1.0 16.741012117576524 -5.230030343280962 2.0526249790290487 0.9857686160637895 1.383096995342743 0.7022545670867508 0.09108123733816045 0.21984514348716497 1.6580685174036223 0.027266464763330407 0.11330499017069864 5.888025154722727e-06 5.230030343280962 0.3973283792789535 AEDGATPSPS(ph)NETPKKK ddPTM_A459_Selumetinib_30min_R1 1 AEDGATPSPSNETPKKK 17 2 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGATPS(0.006)PS(0.716)NET(0.278)PKKK 61.477 0.021952 25026000.0 5164.5 3879.1 15567.0 17876.0 8121.4 9040.1 4905.9 5052.1 4329.0 3311.6 True False 5284.822801632334 3424.933168655336 13453.086903410205 14754.292174079026 7386.820803949629 8949.164801754065 4535.8440132372525 4918.101896466418 7345.99682234968 3736.676117715625 1.4143111779415207 0.9165721247334464 3.6002817690377187 3.9485070980941472 1.9768426728044814 2.3949533006957626 1.2138713311899747 1.316170238343548 1.9659174600448306 1.0 11.867539805936188 -7.253412300901976 22.601730874305254 1.4003372527559255 2.418027834645659 0.23659218666304738 0.8785834639607311 272.7961230765287 768110.6776173648 0.37671820212357215 0.28567047514014815 5.5794025822906664e-08 7.253412300901976 1.0176905818897337 AEDGATPSPSNET(ph)PK ddPTM_A459_Selumetinib_30min_R1 7 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGATPSPS(0.001)NET(0.999)PK;AEDGATPSPSNET(1)PK;AEDGATPSPSNET(1)PK;AEDGATPSPSNET(0.999)PK;AEDGATPSPSNET(1)PK;AEDGATPSPSNET(1)PK;AEDGAT(0.002)PS(0.047)PS(0.205)NET(0.746)PK 262.73 3.1460000000000006e-36 1402954600.0 34697.0 41109.2 39713.6 38488.8 28951.499999999996 33710.5 32089.9 32019.100000000002 23269.599999999995 34475.8 True False 35505.37259139063 36296.11575285139 34320.711251189794 31767.45360425669 26332.841936802484 33371.40297668506 29669.33300727329 31169.84945530527 39486.81165565908 38901.1047527299 0.912708593164029 0.9330356035789521 0.8822554389996167 0.8166208596435143 0.676917586381774 0.8578523203596989 0.7626861292465282 0.8012587214021964 1.0150563051268635 1.0 15.247523506448658 -8.265342151271376 24.808289386684137 1.0075281872456805 0.8286457882607249 0.5004659137376658 0.07076081465400198 285.7808534503818 1816545.6322614246 0.0663106001670118 0.01964316511835127 5.428225098187466e-09 8.265342151271376 -0.17888239898495562 AEDGATPSPSNET(ph)PK ddPTM_A459_Selumetinib_30min_R2 7 AEDGATPSPSNETPK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGATPSPSNET(1)PK;AEDGATPSPSNET(1)PK;AEDGAT(0.093)PS(0.284)PS(0.022)NET(0.601)PK;AEDGATPSPS(0.008)NET(0.992)PK;AEDGATPSPSNET(1)PK;AEDGATPSPSNET(1)PK;AEDGATPS(0.02)PS(0.006)NET(0.974)PK 254.89 1.9058999999999997e-78 976774600.0 577702.9 495232.5 482925.6 442361.0 393848.3 314973.1 470786.2 381160.1 265221.3 392493.3 True False 545596.485545941 533215.240326532 451854.69266563706 382110.66868471174 344369.55550552445 358357.7854838763 492678.691145158 382269.2127865482 318272.9709022897 381160.99860893673 1.431406905578269 1.3989239252508094 1.1854693799069158 1.0024915195396193 0.9034753208285102 0.9401743273622387 1.2925737232907089 1.0029074700235752 0.8350092797107794 1.0 18.540040980903775 -5.447649385902273 2.2811918754510083 1.0022952258652307 1.4292499281209299 0.6881820743319909 0.11263922221910387 0.19081323204174164 1.9159748307289446 0.034336389403577215 0.09112368101270897 3.5673901931790346e-06 5.447649385902273 0.4269547022556992 AEDGATPSPSNET(ph)PKK ddPTM_A459_Selumetinib_30min_R1 2 AEDGATPSPSNETPKK 16 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGATPSPS(0.001)NET(0.998)PKK;AEDGATPSPSNET(1)PKK 117.84 0.002259 633990000.0 8334.400000000001 10503.0 10695.4 10950.4 8879.8 10101.1 9187.5 8860.7 5723.5 9680.099999999999 True False 8528.57530408065 9273.303877287772 9243.023425626876 9038.118204466042 8076.623657856021 9999.49210506499 8494.479478101319 8625.685452390087 9712.361472099421 10922.63512715878 0.7808166440417499 0.8489987781638885 0.8462265120112268 0.827466824557112 0.7394391155458225 0.915483488064302 0.7776950689289318 0.7897073693272606 0.8891958175870901 1.0 13.415033333450232 -8.571474041857268 3.701848123428586 0.9998371321431663 0.8181929579127212 0.6033021270673613 0.04628298288424589 0.16678949164926968 6.600646600050018 0.04312004087648263 0.011338418770872901 2.6824149329907003e-09 8.571474041857268 -0.1816441742304451 AEDGATPSPSNET(ph)PKK ddPTM_A459_Selumetinib_30min_R2 3 AEDGATPSPSNETPKK 16 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGAT(0.001)PSPS(0.053)NET(0.945)PKK;AEDGAT(0.001)PS(0.106)PS(0.066)NET(0.827)PKK;AEDGATPS(0.058)PS(0.015)NET(0.927)PKK 117.37 0.002305 577477000.0 136888.0 184217.0 116942.0 142163.0 124377.0 104518.0 131431.0 120954.0 93117.0 125059.0 True False 129280.31296608131 198345.8515489852 109418.07903682248 122800.15415514637 108751.64931551224 118914.40578006118 137542.80192558575 121305.95611498725 111743.0019063647 121448.22172769558 1.064489138885429 1.6331721348189452 0.90094426645582 1.0111317597591674 0.8954569096890452 0.9791366566624946 1.1325221561002066 0.9988285904010409 0.9200875921996505 1.0 16.889981840298468 -5.283084514852346 24.96602947847626 0.9832642675915253 1.3488307014239667 0.5166819956067566 0.14274878151697964 496.26090845979604 572398.7969106795 0.034773363100139676 0.07248732546871975 5.210932951070194e-06 5.283084514852346 0.36556643383244136 AEDGATPSPSNET(ph)PKKK ddPTM_A459_Selumetinib_30min_R1 4 AEDGATPSPSNETPKKK 17 2 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 AEDGATPS(0.001)PS(0.025)NET(0.975)PKKK;AEDGATPSPS(0.018)NET(0.982)PKKK;AEDGAT(0.001)PSPS(0.013)NET(0.985)PKKK;AEDGATPS(0.002)PS(0.004)NET(0.994)PKKK 105.92 0.0084618 78098000.0 6575.0 5780.9 23578.5 24355.3 10515.9 11556.6 6330.0 6226.2 5601.1 4226.25 True False 6728.184707277101 5104.069540532504 20376.669207429666 20102.104060603415 9564.738701732942 11440.351096553248 5852.523003687761 6061.060950452127 9504.657611841718 4768.730354661087 1.4108964455708402 1.0703204335182523 4.2729757591584 4.215399606512679 2.0057201792473136 2.3990350147122776 1.2272706922854937 1.2710009792287544 1.9931212094119781 1.0 12.219389493271608 -7.04768077648382 2.1922558201664146 1.393031111550389 2.703142411913168 0.24709393378780897 1.0081284834949327 0.5106477737004467 4.878666011557805 0.4924383014167826 0.37391915210611315 8.960231357831421e-08 7.04768077648382 1.3101113003627791 AEDGS(ph)VIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R1 1 AEDGSVIDYELIDQDAR 17 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 1 AEDGS(1)VIDYELIDQDAR 255.23 2.9789e-31 4531800.0 459.35 622.49 597.66 479.08 633.15 634.39 508.3 560.39 390.77 421.11 True False 470.05196126049196 549.6085814122503 516.501054711386 395.4176714453889 575.8816942917114 628.0086125800339 469.95852176532225 545.5266367967412 663.1081492884234 475.16357045875947 0.989242421944653 1.156672387324676 1.0869963246818695 0.8321716899795628 1.2119651633556647 1.3216682667269841 0.98904577493512 1.1480817779655283 1.3955365910063513 1.0 8.892280422518768 AEDGSVIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R1 3 AEDGSVIDYELIDQDAR 17 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 ;; 445.33 0.0 64091000.0 9025.8 10280.5 9625.6 9899.900000000001 10323.7 8680.5 9017.699999999999 9074.6 5695.3 6998.300000000001 False True 9236.083578850445 9076.854280725218 8318.49638963611 8171.068309138782 9389.923157797268 8593.182051263388 8337.487628808072 8833.912129544975 9664.508131745932 7896.599974214656 1.169627891625472 1.149463605901848 1.0534276038800374 1.0347577863663306 1.189109640662927 1.088212911800437 1.0558325932721777 1.118698193955752 1.2238821978198409 1.0 12.947015892863243 -11.76592506499252 2.5351846696477103 0.5213366098500655 1.1158394000637148 0.2635585887218428 0.0599226475717868 7327904.854469273 5927576.779643609 21938470.045995485 0.0154778071592334 1.714253066469316e-12 11.76592506499252 0.5945027902136494 AEDGSVIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R2 2 AEDGSVIDYELIDQDAR 17 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 ; 420.7 0.0 65577000.0 152681.0 128015.0 149964.0 180326.0 169334.0 110589.0 137783.0 124084.0 107627.0 137153.0 False True 144195.60125046948 137833.3388668977 140315.47950845785 155765.28772029944 148060.74905483273 125821.63092301023 144190.18251183495 124445.06389678804 129155.40734963848 133193.03652370992 1.0826061558015534 1.0348389260001725 1.0534745897431361 1.169470204942519 1.1116252990333784 0.9446562238305342 1.082565472453715 0.9343210962431611 0.9696858838911395 1.0 17.023159133157407 -6.753953443441209 24.999986743607433 0.9881607849764086 1.0896571906734096 0.5161798429092171 0.05040016020752525 154.15379350806148 514810.2471092496 0.017570622986163537 0.017244089391504583 1.7621649411406134e-07 6.753953443441209 0.10149640569700102 AEDMYSAQSHQAAT(ph)PPKDGK ddPTM_A459_Selumetinib_30min_R1 4 AEDMYSAQSHQAATPPKDGK 20 1 J9JIE0;A8MXZ4;A0A0C4DFY5;Q9NQ84;Q9NQ84-2 J9JIE0 GPRC5C G-protein coupled receptor family C group 5 member C 1 AEDMYSAQSHQAAT(1)PPKDGK;AEDMYSAQSHQAAT(1)PPKDGK;AEDMYSAQSHQAAT(1)PPKDGK;AEDMYSAQSHQAAT(1)PPKDGK 145.25 3.7502e-05 22588300.0 10358.2 6719.3099999999995 10801.15 7454.85 10053.43 7540.249999999999 8247.83 9560.250000000002 3665.35 7240.32 True False 10599.525906451348 5932.61006147753 9334.413156470036 6153.000392365907 9144.099031577225 7464.401930999229 7625.689542733974 9306.681113931449 6219.831243427903 8169.685598689089 1.2974215198871488 0.7261736072719223 1.1425669989023617 0.7531502060927804 1.1192718399156623 0.9136706475212425 0.9334128529937058 1.139172493421877 0.7613305516219547 1.0 12.996064843578964 -4.733962592764837 24.744842588482943 0.9521091649090164 1.2974235981417221 0.32756217862419224 0.1517757894538178 3059.079520551587 2754757.097711978 0.03401633200834309 3.128136177424266 1.84517434336791e-05 4.733962592764837 0.3453144332327057 AEDMYSAQSHQAAT(ph)PPKDGK ddPTM_A459_Selumetinib_30min_R2 2 AEDMYSAQSHQAATPPKDGK 20 1 J9JIE0;A8MXZ4;A0A0C4DFY5;Q9NQ84;Q9NQ84-2 J9JIE0 GPRC5C G-protein coupled receptor family C group 5 member C 1 AEDMYSAQSHQAAT(1)PPKDGK;AEDMY(0.001)S(0.001)AQS(0.001)HQAAT(0.997)PPKDGK 92.633 0.00077835 47986000.0 305080.0 90649.0 185076.0 216400.0 115183.0 117183.0 354040.0 232713.0 161336.0 134167.0 True False 288124.8749320033 97601.48681752465 173168.41165551258 186925.94668917856 100712.68179091501 133323.89456863815 370503.56151695066 233390.15630228896 193607.7081044842 130293.25010227018 2.2113568792385445 0.7490908910547169 1.3290666363728643 1.434655644420997 0.7729692958911019 1.0232601801243668 2.843612859654156 1.7912682055217415 1.4859381276659922 1.0 16.9914028208431 AEDNADTLALVFEAPNQEK ddPTM_A459_Selumetinib_30min_R2 4 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 ;;; 307.07 9.405199999999994e-197 0.0 54834.0 46839.0 52061.0 52748.0 54777.0 38437.8 41927.7 43199.5 36104.7 45608.0 False True 51786.54579789389 50431.400688877235 48711.45193973099 45563.631404624626 47895.4235474068 43732.258046392395 43877.42112816139 43325.20339293779 43326.64884960554 44291.17853618494 1.1692293479069515 1.1386330722194684 1.0998003112501236 1.0287292619093467 1.081376136972225 0.9873807717865101 0.9906582434313523 0.978190349067863 0.9782229843852224 1.0 15.434731765702194 -5.419656956319632 0.5385145995491685 0.9776175863073527 1.2313604877644175 0.8943850717621725 0.02204423454679395 0.6592696915083769 0.23601897796783475 0.014204666777812963 0.09707471610590243 3.8048982171835156e-06 5.419656956319632 0.2537429014570648 AEDQTES(ph)SCESHR ddPTM_A459_Selumetinib_30min_R1 1 AEDQTESSCESHR 13 0 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 1 AEDQT(0.001)ES(0.653)S(0.345)CES(0.001)HR 88.385 0.015788 343110.0 366.84 367.72 612.25 384.34 490.18 323.39 414.31 373.46 398.81 429.52 True False 375.38665825361676 324.66717145161 529.1098128485194 317.2222339553327 445.84330554830797 320.1369902146267 383.05826313710526 363.55462763095505 676.7514420700566 484.6530758790966 0.7745471491596644 0.6698960299853801 1.091728989625794 0.6545346552891127 0.9199225750081276 0.6605487639461289 0.7903762138356147 0.7501337466424102 1.3963626266944018 1.0 8.920808597276682 -8.247169873400303 24.833266032391517 1.1981813145036133 0.7907357043417867 0.5297199804726498 0.15422393716669397 451.02027213697954 784915.7431897726 0.09771174310254235 0.03654699391852496 5.6601784900663985e-09 8.247169873400303 -0.40744561016182657 AEDQTES(ph)SCESHR ddPTM_A459_Selumetinib_30min_R2 3 AEDQTESSCESHR 13 0 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 1 AEDQTES(0.996)S(0.004)CESHR;AEDQTES(0.993)S(0.007)CESHR;AEDQTES(0.94)S(0.06)CESHR 178.22 7.020000000000001e-05 6872600.0 41057.2 28520.600000000002 38200.9 44755.0 42973.9 36489.4 38249.7 46038.0 31953.2 43664.0 True False 38775.40518899388 30708.038311816905 35743.095683995096 38659.29179331872 37575.13449045955 41515.4836322066 40028.386840342646 46171.96295799884 38344.7328470037 42403.30686730354 0.9144429539502007 0.724189705484865 0.8429317976508097 0.911704644033983 0.8861368904092028 0.9790624057252119 0.9439921033896498 1.088876466698432 0.9042863795269389 1.0 15.371889158843274 -6.356045808300115 0.980509564413572 0.9945089128479447 0.8145906436312299 0.5094739960629637 0.06447863300780986 0.4091373402396645 0.8404792211746341 0.029957835776483335 0.042254821637193136 4.4050839732759325e-07 6.356045808300115 -0.17991826921671483 AEDQTES(ph)SCESHRK ddPTM_A459_Selumetinib_30min_R1 1 AEDQTESSCESHRK 14 1 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 1 AEDQT(0.026)ES(0.755)S(0.219)CESHRK 84.895 0.012984 12847000.0 2570.4 3019.6 3068.7 2693.7 3077.3 3607.9 3044.0 3716.1 3482.6 2811.6 True False 2630.285318872251 2666.0638282260456 2651.9873951625154 2223.2958620114473 2798.958758341444 3571.6078017111004 2814.3886292615402 3617.536956406019 5909.717840959809 3172.496247303194 0.8290901277213948 0.8403678429855842 0.8359308217990356 0.7008033071438233 0.8822575474189202 1.125803633257935 0.8871211846677309 1.1402809253064161 1.8627974252084338 1.0 11.631402742187799 -7.98613843296607 4.574673191275463 1.4576760181365755 0.8770893696783493 0.5126834533778661 0.2181508658544294 0.13589352371128466 7.198660953519381 0.13152320866556103 0.05508773585548735 1.0324322617192903e-08 7.98613843296607 -0.5805866484582263 AEDQTESSCESHR ddPTM_A459_Selumetinib_30min_R2 1 AEDQTESSCESHR 13 0 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 0 115.06 0.0074762 0.0 0.0 591.14 0.0 735.8 1049.5 501.29 523.05 919.15 819.99 906.43 False True 0.0 636.4785371853136 0.0 635.5827706742017 917.6524273509576 570.338147242455 547.3728614039126 921.8245743265263 984.010912434892 880.2590107120268 0.0 0.7230582469930944 0.0 0.7220406300187594 1.042480015749778 0.6479208281902369 0.6218315913189594 1.047219696826367 1.117865197016208 1.0 9.781784279989255 -5.735433182379859 0.45647184398604296 1.029388700311851 6.2979392022804526e-15 0.5469867649701107 0.25995411586761125 1.8873249021927423 0.5658847826472557 0.2177858574179663 0.9680900690914669 1.838936858523986e-06 5.735433182379859 -1.0293887003118447 AEDS(ph)DSEPEPEDNVR ddPTM_A459_Selumetinib_30min_R2 1 AEDSDSEPEPEDNVR 15 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 AEDS(0.999)DS(0.001)EPEPEDNVR 205.52 3.0147e-06 2259000.0 5512.7 4904.4 5383.6 7122.3 4703.1 5595.1 3693.4 5320.7 4710.7 5636.3 True False 5206.326203086583 5280.5517098684795 5037.225037220485 6152.230453347198 4112.254531752537 6365.774237739156 3865.150418333258 5336.182356110696 5652.971627955271 5473.565374133905 0.9511763991510547 0.9647371226846877 0.9202822461981716 1.1239895813468164 0.7512935811793843 1.1630032351164579 0.7061485803382498 0.9749006344799622 1.0327768541267774 1.0 12.418265167396449 AEEDEILNRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 5 AEEDEILNRSPR 12 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR 138.31 0.00068846 3443190000.0 18052.8 26884.800000000003 28195.8 24759.199999999997 29550.2 28985.1 29870.2 27214.8 13225.2 22701.300000000003 True False 18473.395115366086 23737.115117595575 24366.965228443067 20435.470507745427 26877.389627511548 28693.536210365135 27617.066765364016 26492.97509787103 22442.198469609382 25615.23298438752 0.7211878621844126 0.9266796492564929 0.9512685378772361 0.7977858534490334 1.0492736741412156 1.1201747111905576 1.078150129737122 1.0342664114754878 0.8761270484359014 1.0 14.644714393492691 -6.272000504747311 24.59117726219246 1.035328368886172 0.8620509923972018 0.5075390909079902 0.08481180899864418 500.5992444143362 1165623.7565319443 0.027058787501324903 0.03097984555501351 5.345637381140005e-07 6.272000504747311 -0.17327737648897024 AEEDEILNRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 8 AEEDEILNRSPR 12 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR;AEEDEILNRS(1)PR 163.33 0.00027488 4866560800.0 1951433.0 585380.0 1592025.0 1750086.0 818191.0 821771.0 2236145.0 1400035.0 1362833.0 1205061.0 True False 1842980.16606524 630276.7637066325 1489595.8447657593 1511721.2677332568 715402.5318596542 934962.4959555939 2340130.173337258 1404108.87006173 1635437.680735597 1170267.7578055044 1.5748363173921935 0.5385748342657347 1.2728675423469424 1.2917738335097335 0.6113152542125768 0.7989304069257135 1.999653632879273 1.1998184694883216 1.397490163962462 1.0 20.158407226195074 -7.206196966199803 24.999930239127853 1.4158977118794371 0.9990648154372982 0.19488132569403582 0.38149521413716775 457.62183606262255 207096.5818504367 0.1415836942853943 0.10967020655785645 6.220181164185566e-08 7.206196966199803 -0.41683289644213894 AEEDMDEAIEKGEAEQS(ph)EEEADEEDKAEDAR ddPTM_A459_Selumetinib_30min_R1 1 AEEDMDEAIEKGEAEQSEEEADEEDKAEDAR 31 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AEEDMDEAIEKGEAEQS(1)EEEADEEDKAEDAR 86.99700000000001 4.3723e-07 4972500.0 1761.9 1504.5 522.84 414.45 794.06 755.01 1290.9 1647.7 988.33 2474.0 True False 1802.9488419393958 1328.3524405769263 451.84119975454405 342.074087690034 722.2374132026797 747.4152848942315 1193.526373690448 1603.997643516105 1677.1238252328155 2791.5619988007193 0.6458566360746991 0.47584558077076516 0.16185963268903186 0.12253859589612989 0.2587216094476711 0.2677408867205271 0.4275478653897703 0.5745878630692054 0.6007832983660486 1.0 11.44685688246724 -8.4494271117316 0.9137264101257955 0.9880652635602931 0.31134196090685196 0.6556003783524722 0.14849019743862038 0.3848010194299202 0.7123135683182936 0.1564195336811302 0.054664489265258985 3.552817409252012e-09 8.4494271117316 -0.6767233026534412 AEEGDADEKLFEES(ph)DDKEDEDADGK ddPTM_A459_Selumetinib_30min_R2 1 AEEGDADEKLFEESDDKEDEDADGK 25 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 AEEGDADEKLFEES(1)DDKEDEDADGK 42.289 0.034369 3242500.0 22813.0 13298.0 14857.0 17449.0 10674.0 11528.0 21828.0 18310.0 10957.0 13214.0 True False 21545.144787674682 14317.91384019064 13901.11679507853 15072.41609879608 9333.03669322927 13115.877359235226 22843.045251361462 18363.279068616313 13148.70616415946 12832.477485904841 1.6789544194673096 1.1157560070467607 1.083276149157283 1.174552311925081 0.7272981155416522 1.022084579820356 1.7800962656238595 1.4310002950549876 1.0246428391245543 1.0 13.647512108946408 AEEKENDTVTIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AEEKENDTVTISPK 14 1 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 AEEKENDTVT(0.001)IS(0.999)PK;AEEKENDTVT(0.006)IS(0.994)PK 178.22 0.00033829 50748000.0 7382.299999999999 7763.36 9459.9 8955.2 6543.99 6893.7300000000005 6798.780000000001 6799.8 4844.209999999999 7383.31 True False 7554.293226544745 6854.422202111855 8175.297539511159 7391.3424299235 5952.087259935271 6824.3853352060305 6285.942550870824 6619.447215136738 8220.270562900103 8331.029758029636 0.9067658435937942 0.8227580984818121 0.9813069664805388 0.8872063411848405 0.7144479653548848 0.819152677810151 0.7545216778048703 0.7945533034204763 0.9867052215216516 1.0 13.024279115785124 -8.272558882755055 23.294292691933773 0.9933527463133883 0.8340510794792776 0.4331949640206392 0.0724051046845685 331.67702453173973 694813.2208754058 0.07251075067283787 0.019549644713975682 5.338768842754202e-09 8.272558882755055 -0.15930166683411073 AEEKENDTVTIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 AEEKENDTVTISPK 14 1 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 AEEKENDTVT(0.001)IS(0.999)PK;AEEKENDTVT(0.046)IS(0.954)PK;AEEKENDTVTIS(1)PK 180.7 6.993e-10 48834000.0 263459.1 261648.5 232782.4 217939.9 200072.3 157210.4 204237.4 195375.2 115125.8 204555.9 True False 248817.09793233947 281716.09861747077 217805.4338183135 188256.10965270273 174937.42900494425 178864.70558607866 213734.84378873062 195943.70948589436 138154.17688361643 198649.83966694452 1.2525411465194494 1.4181541706240226 1.0964289434287244 0.9476781353981062 0.8806321177920083 0.9004019630016439 1.075937660695209 0.9863773855262745 0.6954658363442182 1.0 17.59986810344401 -5.502609357806513 2.9927705081139773 0.9295673794393204 1.3343081479908454 0.7165996859985415 0.1019975397319485 0.13255763498410167 2.3838475831371353 0.028508180755154704 0.06273167113577506 3.1433348111159027e-06 5.502609357806513 0.40474076855152497 AEEKS(ph)PISINVK ddPTM_A459_Selumetinib_30min_R2 1 AEEKSPISINVK 12 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 1 AEEKS(0.971)PIS(0.029)INVK 127.32 0.012387 56330000.0 31531.0 45342.0 29801.0 32508.0 29596.0 25051.0 26426.0 32117.0 19154.0 27375.0 True False 29778.633248593793 48819.585602490944 27883.636104875488 28080.354320572093 25877.885888403005 28501.54785966357 27654.86136212561 32210.455152744416 22985.33520747559 26584.612621208184 1.1201454643291489 1.8363850659815353 1.0488637356570316 1.0562634378268376 0.973415947680901 1.0721069464418724 1.0402582033511982 1.2116202561119191 0.8646104998776161 1.0 14.698303823832394 -5.355257410243858 11.376203307488916 1.0408649655937119 1.478004073974346 0.4937929200449669 0.1800530685076016 0.43663662031995626 51.03131416247063 0.04277495108838044 0.08908709717506978 4.413088021267176e-06 5.355257410243858 0.4371391083806342 AEENTDQAS(ph)PQEDYAGFER ddPTM_A459_Selumetinib_30min_R1 2 AEENTDQASPQEDYAGFER 19 0 Q9NU22 Q9NU22 MDN1 Midasin 1 AEENTDQAS(1)PQEDYAGFER;AEENTDQAS(1)PQEDYAGFER 281.53 1.0029999999999996e-71 25297000.0 1360.67 2259.3999999999996 2123.8 1986.1100000000001 1690.65 2112.8 1718.17 1621.91 792.5799999999999 1292.9699999999998 True False 1392.37096359707 1994.8683976334362 1835.3996251983417 1639.2731724021085 1537.731006008501 2091.5471502689115 1588.567053593397 1578.891678093831 1344.95037224715 1458.9352940943259 0.9543747205467549 1.367345355005484 1.2580404577419704 1.1236092368440043 1.05400905182919 1.4336120037230964 1.088853672965355 1.0822218671966335 0.9218711602162348 1.0 10.510700183709991 -7.826986765379964 2.2727196311966424 0.9718198808163866 1.1998817020798151 0.3004173484947791 0.1363463955092872 0.3769182929995405 3.811172673142082 0.09482784373355409 0.038035071036594384 1.4894064649518813e-08 7.826986765379964 0.22806182126342855 AEENTDQAS(ph)PQEDYAGFER ddPTM_A459_Selumetinib_30min_R2 2 AEENTDQASPQEDYAGFER 19 0 Q9NU22 Q9NU22 MDN1 Midasin 1 AEENT(0.013)DQAS(0.987)PQEDYAGFER;AEENTDQAS(1)PQEDYAGFER 157.88 2.6758e-06 29548000.0 86626.0 66933.0 106490.0 121160.0 120651.0 95445.0 81834.0 94603.0 83258.0 100370.0 True False 81811.67371135358 72066.54587648377 99638.54933754538 104657.79898734204 105493.74274637488 108591.68238655491 85639.44315099478 94878.27906763021 99911.92642288853 97472.05730742171 0.8393346357030702 0.73935595356513 1.0222268010953197 1.0737210425061297 1.0822972825294248 1.1140801311299144 0.878605064022528 0.9733895199153244 1.02503147243288 1.0 16.57270107470123 -5.269163527068727 24.630058538512014 1.0225052592836892 0.7893452909880437 0.6654904193558235 0.06573776808223827 260.263585681921 829907.4472737809 0.01856180580465761 0.03986809591219317 5.380671432614855e-06 5.269163527068727 -0.23315996829564545 AEEPPS(ph)PPVPK ddPTM_A459_Selumetinib_30min_R2 2 AEEPPSPPVPK 11 0 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 AEEPPS(1)PPVPK;AEEPPS(1)PPVPK 132.14 0.002068 39755000.0 437340.0 390180.0 429560.0 447200.0 411560.0 325640.0 368760.0 370450.0 303470.0 363950.0 True False 413034.3936107332 420105.5513735593 401922.577269566 386290.5885369711 359856.15340691735 370493.95413439913 385908.07068407733 371527.94816870097 364172.47966025985 353441.81784433743 1.1686064657822735 1.188613033782499 1.1371675816996292 1.0929396835184366 1.0181482078201762 1.0482459500521577 1.091857418111285 1.0511714500414011 1.0303604759656606 1.0 18.431113218422205 -5.775680897462711 2.022226365406236 1.0456231591482767 1.1775818171631236 0.8404813259878622 0.024516556377085184 0.12433445585456823 1.0380191951558564 0.00764086149120727 0.014808529972949 1.6761740105419638e-06 5.775680897462711 0.13195865801484685 AEEQQLPPPLS(ph)PPS(ph)PSTPNHR ddPTM_A459_Selumetinib_30min_R1 8 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 AEEQQLPPPLS(0.999)PPS(0.687)PS(0.173)T(0.141)PNHR;AEEQQLPPPLS(0.999)PPS(0.737)PS(0.149)T(0.115)PNHR;AEEQQLPPPLS(1)PPS(0.707)PS(0.163)T(0.13)PNHR;AEEQQLPPPLS(0.998)PPS(0.739)PS(0.145)T(0.118)PNHR;AEEQQLPPPLS(0.999)PPS(0.881)PS(0.065)T(0.055)PNHR;AEEQQLPPPLS(0.996)PPS(0.866)PS(0.093)T(0.044)PNHR;AEEQQLPPPLS(1)PPS(0.703)PS(0.165)T(0.132)PNHR;AEEQQLPPPLS(1)PPS(0.7)PS(0.167)T(0.134)PNHR 132.94 0.00017901 23607900.0 11619.07 13614.77 10357.74 11589.519999999999 16409.429999999997 11721.59 14306.53 11834.03 4567.49 8324.060000000001 True False 11889.771724225424 12020.746399065149 8951.215798993257 9565.627894234298 14925.199953820169 11603.681446952185 13227.37692384661 11520.153082053106 7750.696933729257 9392.534184210632 1.2658747352991044 1.2798192866066633 0.9530139175900733 1.0184288613305923 1.5890493088553517 1.2354154075327843 1.4082862691181428 1.2265223480814282 0.8251976284269059 1.0 13.197298746239957 -8.247370087093959 20.66156743509242 0.9125991356083876 1.247108323578688 0.3744826787275478 0.17290124992115946 77.42776160288531 113711.96098553842 0.12551729818435592 0.04656617731839023 5.657569697849526e-09 8.247370087093959 0.3345091879703004 AEEQQLPPPLS(ph)PPS(ph)PSTPNHR ddPTM_A459_Selumetinib_30min_R2 2 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 AEEQQLPPPLS(1)PPS(0.949)PS(0.04)T(0.011)PNHR;AEEQQLPPPLS(0.998)PPS(0.723)PS(0.157)T(0.123)PNHR 128.55 0.00023521 15782400.0 179605.0 149415.0 236460.0 279630.0 311300.0 207156.0 197649.0 206540.0 242270.0 252150.0 True False 169623.2731157811 160874.6500550526 221246.42103818222 241543.91161134405 272191.7109426899 235689.85862506318 206840.07013406346 207140.9972054623 290730.7695893862 244869.77433562145 0.6927080877009075 0.6569804317071648 0.9035268711235026 0.9864178307294108 1.1115774157149372 0.9625110296464104 0.8446941673191808 0.8459230942956332 1.1872872851628764 1.0 17.90165517930118 -5.370336591218281 3.243140726133603 0.9811969185324133 0.6708388571658012 0.6099801288925624 0.0993405126492268 0.1730524200719209 3.3922936040300797 0.0280977309614001 0.06836132803805464 4.262490349945217e-06 5.370336591218281 -0.31035806136661215 AEEQQLPPPLS(ph)PPSPST(ph)PNHR ddPTM_A459_Selumetinib_30min_R1 1 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 AEEQQLPPPLS(0.995)PPS(0.097)PS(0.265)T(0.644)PNHR 73.60300000000002 0.012023 1850700.0 769.65 939.19 891.22 587.15 1013.8 772.73 1000.1 794.53 319.22 580.68 True False 787.5813475217973 829.2291981824143 770.1972191210406 484.61527467053554 922.1019690009279 764.9570377827042 924.6616518148704 773.4564834028346 541.6930250936626 655.2159343021827 1.2020180009214614 1.2655815507074915 1.1754860936666858 0.7396268150692334 1.4073253117431945 1.167488453401851 1.4112319365365442 1.1804604297766053 0.826739700203683 1.0 9.355826632314098 -8.246686395775733 21.95083264161272 0.9133699780999219 1.1938132814891371 0.281651506242693 0.1790470236639766 183.5348209458068 273084.9395047525 0.12429749059843218 0.046332262502218904 5.666483183244354e-09 8.246686395775733 0.2804433033892152 AEEQQLPPPLS(ph)PPSPSTPNHR ddPTM_A459_Selumetinib_30min_R1 3 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEEQQLPPPLS(0.468)PPS(0.059)PS(0.139)T(0.334)PNHR;AEEQQLPPPLS(1)PPSPSTPNHR;AEEQQLPPPLS(0.999)PPSPSTPNHR 148.17 1.699e-06 93227400.0 7553.4 8287.099999999999 7438.8 8378.4 10691.0 6976.17 9040.4 7820.64 2978.1800000000003 5920.68 True False 7729.379523642101 7316.8424794317325 6428.6518184035385 6915.269722046524 9724.000937649356 6905.996063655561 8358.4753495322 7613.211222181093 5053.753942338967 6680.656950306968 1.1569789589760249 1.0952279893814234 0.9622783906166819 1.035118218684882 1.455545616244006 1.033730082988057 1.2511457199053064 1.1395902047973405 0.7564755951294212 1.0 12.705774263461409 -8.242976698182954 23.888701008332188 0.8782378346242068 1.140729747146237 0.35877926442526686 0.14061868784102907 433.14595659568823 560446.7774505661 0.09594093367695196 0.03608609416210137 5.7150929984730015e-09 8.242976698182954 0.2624919125220302 AEEQQLPPPLS(ph)PPSPSTPNHR ddPTM_A459_Selumetinib_30min_R2 4 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEEQQLPPPLS(0.914)PPS(0.018)PS(0.018)T(0.05)PNHR;AEEQQLPPPLS(0.997)PPS(0.001)PS(0.001)T(0.002)PNHR;AEEQQLPPPLS(0.997)PPS(0.002)PS(0.001)TPNHR;AEEQQLPPPLS(0.94)PPS(0.016)PS(0.022)T(0.022)PNHR 126.86 4.2547e-05 106924000.0 153649.0 149439.0 213786.0 239171.0 287406.0 198380.0 167125.0 196876.0 181369.0 231218.0 True False 145109.80368568032 160900.49077788007 200031.24151259754 206595.4972070123 251299.4888377602 225705.0442856592 174896.64365190503 197448.8765654235 217647.8678732714 224542.13556348914 0.6462475442371957 0.7165714816691301 0.8908405587691529 0.9200745182571649 1.1191640633822397 1.005179022276829 0.7789034481791197 0.8793399780844027 0.969296329738218 1.0 17.77662666802059 -5.24198880424855 2.079964191285651 0.9495430776651066 0.6444277638807197 0.6276047415550052 0.08344010352268938 0.2652335954977363 2.0726267365317885 0.026034714885441616 0.10428751868736638 5.728107973826452e-06 5.24198880424855 -0.30511531378438694 AEEQQLPPPLSPPS(ph)PSTPNHR ddPTM_A459_Selumetinib_30min_R1 2 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEEQQLPPPLS(0.074)PPS(0.759)PS(0.108)T(0.059)PNHR;AEEQQLPPPLS(0.007)PPS(0.479)PS(0.479)T(0.034)PNHR 149.04 1.5036e-06 65442000.0 8931.2 10197.3 8805.0 9550.0 11830.6 8558.1 10991.3 9523.7 2920.3 7114.4 True False 9139.27958291 9003.395375403845 7609.329362402953 7882.2717757023165 10760.52431886208 8472.013284133087 10162.217391853608 9271.100538662578 4955.535809726907 8027.602540124429 1.1384818240849701 1.1215547020922003 0.9478956294073084 0.9818961185863769 1.340440594197043 1.0553603322769602 1.2659093846587095 1.154902786021451 0.6173120536246798 1.0 12.970753472913872 -8.241634048804439 24.644987949202335 0.8086560133231111 1.124412714297986 0.44923382018542846 0.1404591277235441 522.1555324618303 649752.7433348596 0.09405983658685288 0.03543964644605901 5.7327889167230985e-09 8.241634048804439 0.31575670097487496 AEEQQLPPPLSPPS(ph)PSTPNHR ddPTM_A459_Selumetinib_30min_R2 3 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEEQQLPPPLS(0.003)PPS(0.608)PS(0.194)T(0.194)PNHR;AEEQQLPPPLS(0.002)PPS(0.946)PS(0.026)T(0.026)PNHR;AEEQQLPPPLS(0.001)PPS(0.688)PS(0.17)T(0.141)PNHR 228.65 8.037300000000001e-25 49651800.0 158019.0 125688.0 199057.0 214587.0 247312.0 177233.0 155377.0 174254.0 184237.0 195298.0 True False 149236.93658017635 135327.86544938202 186249.88933687482 185359.88041677745 216242.45556266812 201645.23698901263 162602.33837368462 174761.05029069728 221089.54801188738 189659.23929485746 0.7868687923405736 0.7135316262604634 0.9820238129676234 0.9773311392892601 1.140163043818195 1.0631975417528745 0.8573393997478378 0.9214475969662705 1.1657198923389447 1.0 17.53305012901224 -5.316615094101547 5.095170180599709 1.011862148681632 0.7497723131597628 0.5833358506643302 0.08910530861954317 0.13890682495970985 7.870531277461736 0.02472693348764558 0.054744264105215705 4.823751269752145e-06 5.316615094101547 -0.26208983552186915 AEEQQLPPPLSPPSPS(ph)TPNHR ddPTM_A459_Selumetinib_30min_R2 1 AEEQQLPPPLSPPSPSTPNHR 21 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEEQQLPPPLS(0.016)PPS(0.231)PS(0.377)T(0.377)PNHR 140.07 1.3701e-05 7053800.0 44284.0 47400.0 61981.0 75847.0 83485.0 55543.0 49060.0 54432.0 55165.0 63771.0 True False 41822.8725628977 51035.42758497794 57993.209939810346 65516.507756627005 72996.86793463043 63193.54408084677 51341.387210545756 54590.38810829727 66199.54143888444 61929.76553304352 0.6753274811057132 0.8240855935058764 0.9364351607122948 1.0579162894080347 1.178704090130648 1.0204066418938553 0.8290260227636711 0.881488693496987 1.0689454556963034 1.0 15.918345363551673 -5.0460238038906775 1.8911994012566518 0.9996806968875512 0.6571013714714491 0.5640099563001184 0.09251019455471947 0.4149632157506656 2.2755191033712325 0.029303046913585717 0.20895951258410794 8.99448280983494e-06 5.0460238038906775 -0.34257932541610214 AEEYEFLTPVEEAPK ddPTM_A459_Selumetinib_30min_R2 2 AEEYEFLTPVEEAPK 15 0 J3KTF8;J3QQX2;P52565;J3KRE2 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 0 ; 121.04 0.023842 7408700.0 93454.0 86564.0 97834.0 99202.0 98929.0 68707.0 75582.0 84044.0 70084.0 93583.0 False True 88260.2008060032 93203.1804528698 91539.46695360505 85690.51646700477 86500.65458351866 78170.76558995266 79096.71276289181 84288.55412576687 84102.75831057312 90881.01563216546 0.9711621309694664 1.0255517041106048 1.007245202057431 0.9428868710472066 0.9518011433061442 0.860144058098375 0.8703326235154568 0.9274605212041079 0.9254161358734494 1.0 16.47169133718365 -6.021237023454538 1.9089133657748778 0.9116284676065536 1.004287338421187 0.42745647362144945 0.039671047305673064 0.2861079600106121 2.0890634418726064 0.012962855682306504 0.020505856777267024 9.522763015057838e-07 6.021237023454538 0.09265887081463342 AEFEVHEVYAVDVLVSSGEGK ddPTM_A459_Selumetinib_30min_R1 2 AEFEVHEVYAVDVLVSSGEGK 21 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 ; 161.51 2.2073e-08 12607000.0 3551.3 3781.1 3974.0 3114.8 4093.7 2611.94 3150.2 3418.1 2060.69 2574.1000000000004 False True 3634.0383803731042 3338.4070542143 3434.3526276194602 2570.858652037442 3723.4255578014345 2585.666255051771 2912.57787775943 3327.440884446441 3496.8404231572567 2904.5108088572874 1.2511705479942188 1.1493870306950997 1.182420329491088 0.8851262127163118 1.2819458431508919 0.8902243528124592 1.0027774277436126 1.1456114655519376 1.2039343811335335 1.0 11.504079483381238 -5.567391555560995 24.99982783190085 1.0621908732758014 1.1916863205161208 0.20620136093632724 0.12206232330413957 208.45966175463514 117076.70569281378 0.032529106769658214 0.056342072724754014 2.7077492514016905e-06 5.567391555560995 0.12949544724031936 AEFT(ph)SPPSLFK ddPTM_A459_Selumetinib_30min_R1 1 AEFTSPPSLFK 11 0 Q6UN15;Q6UN15-5;Q6UN15-3;A0A0B4J203;Q6UN15-4 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 AEFT(0.912)S(0.057)PPS(0.031)LFK 117.25 0.01322 103460000.0 4438.4 5122.1 6005.6 6219.4 5636.3 5200.1 5067.7 5045.0 3140.1 4455.8 True False 4541.806084376987 4522.402150800311 5190.072506399456 5133.298542597172 5126.497660169586 5147.79171531303 4685.439308971325 4911.190211530466 5328.52035617007 5027.745333167436 0.903348475988876 0.8994891051793262 1.0322862759498113 1.0209941439820776 1.019641473554894 1.0238767825716355 0.9319165945144519 0.9768176162646763 1.0598230425511923 1.0 12.295695860458444 -5.253141428029324 24.77242944824513 1.00604694299209 0.9014187717105607 0.6297166332390265 0.0327111312729261 361.53950565554646 1079321.0538801723 0.008863611711019771 0.02258283912011332 5.582883584867758e-06 5.253141428029324 -0.10462817128152924 AEFTS(ph)PPSLFK ddPTM_A459_Selumetinib_30min_R1 1 AEFTSPPSLFK 11 0 Q6UN15;Q6UN15-5;Q6UN15-3;A0A0B4J203;Q6UN15-4 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 AEFT(0.042)S(0.61)PPS(0.348)LFK 136.93 0.0013747 88807000.0 11257.0 12548.0 13325.0 15096.0 12586.0 11042.0 11372.0 10662.0 6530.9 9643.7 True False 11519.266197690997 11078.874326593057 11515.53818898573 12459.766987015944 11447.598522238777 10930.92750533383 10514.200884350272 10379.209124943078 11082.460301936591 10881.562832592766 1.0586040236047862 1.0181326429884958 1.0582614249576414 1.145034695723678 1.0520178671349123 1.0045365425445327 0.9662399644339541 0.9538344155726396 1.0184621889736363 1.0 13.409598153868574 -6.803729018287776 3.3224805571677862 0.9815990363112318 1.0687332524538546 0.5754545108044306 0.03383260709427207 0.1842707109485721 4.17704257001854 0.01331967698177478 0.012096830569186196 1.5713429512301859e-07 6.803729018287776 0.08713421614262284 AEGAAT(ph)EEEGTPK ddPTM_A459_Selumetinib_30min_R1 4 AEGAATEEEGTPK 13 0 P80723;P80723-2;U3KQP0 P80723 BASP1 Brain acid soluble protein 1 1 AEGAAT(0.999)EEEGT(0.001)PK;AEGAAT(1)EEEGTPK;AEGAAT(1)EEEGTPK;AEGAAT(1)EEEGTPK 190.57 3.6551000000000006e-15 18680100.0 9153.5 10093.8 8885.7 8799.8 8292.0 9315.8 8461.9 9084.7 5321.3 8943.0 True False 9366.758740389498 8912.013203519693 7679.0707456563305 7263.080122704212 7541.990064071504 9222.091510069642 7823.612070285221 8843.744244735542 9029.857447625172 10090.921162196775 0.9282362422451402 0.8831714231309645 0.7609880824779539 0.719763835824385 0.7474035266795828 0.9138998672012228 0.775311980396251 0.8764060389121379 0.8948496675856884 1.0 13.300770258203194 -8.530506722806894 1.0691921996203564 0.9990405027590347 0.8141235598740668 0.3958974015081699 0.06842458656729467 0.6069153712831941 1.522061145504753 0.0700485497123776 0.0227448539927608 2.947767845293658e-09 8.530506722806894 -0.18491694288496785 AEGAAT(ph)EEEGTPK ddPTM_A459_Selumetinib_30min_R2 3 AEGAATEEEGTPK 13 0 P80723;P80723-2;U3KQP0 P80723 BASP1 Brain acid soluble protein 1 1 AEGAAT(1)EEEGTPK;AEGAAT(1)EEEGTPK;AEGAAT(1)EEEGTPK 176.25 0.00023553 23217400.0 116502.0 91499.0 97459.0 100771.0 76018.0 64002.0 112680.0 83522.8 66435.0 89965.0 True False 110027.2852344573 98516.67908434402 91188.594045336 87045.81596032892 66467.93923045753 72817.6945476901 117919.84327118407 83765.83752005614 79723.85634899451 87367.47669285817 1.2593620578199836 1.1276127320316354 1.0437361532817415 0.9963183012179687 0.7607858409843595 0.8334645488696203 1.349699541921455 0.9587759735185709 0.9125118335426473 1.0 16.414808703368465 -5.045231363030196 1.5788777434022914 0.9746798922269575 1.287670870001006 0.2815229882160719 0.14588393581539572 0.9402903415334009 3.2201273053614257 0.04517328499391635 0.39125267538960845 9.01090968763311e-06 5.045231363030196 0.3129909777740485 AEGAATEEEGT(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 AEGAATEEEGTPK 13 0 P80723;P80723-2;U3KQP0 P80723 BASP1 Brain acid soluble protein 1 1 AEGAATEEEGT(1)PK;AEGAATEEEGT(1)PK;AEGAAT(0.006)EEEGT(0.994)PK 172.57 0.00040255 66105100.0 16711.8 17792.9 10756.1 8485.6 10469.2 12049.9 13131.8 14579.9 8150.9 14936.6 True False 17101.152424497865 15709.698996305213 9295.480699028105 7003.749254439745 9522.26270848738 11928.688946433818 12141.257753527163 14193.19368981031 13831.481981817973 16853.858104804687 1.0146728611428548 0.9321129262282505 0.5515342921024211 0.41555762549366193 0.5649900841263628 0.7077720052142361 0.7203844768377361 0.8421332137455295 0.8206715575631257 1.0 14.040791263629663 -8.278999325794917 1.0767761173559112 0.9838274807899944 0.6850309152646024 0.22831213545954698 0.16825193898981994 0.7926059602959491 1.8866088657030453 0.17939165510894328 0.06016314519050512 5.260180829882104e-09 8.278999325794917 -0.298796565525392 AEGAATEEEGT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AEGAATEEEGTPK 13 0 P80723;P80723-2;U3KQP0 P80723 BASP1 Brain acid soluble protein 1 1 AEGAATEEEGT(1)PK;AEGAAT(0.001)EEEGT(0.999)PK 167.03 0.00074065 73021000.0 194158.0 99171.0 115674.0 115607.0 81223.0 87566.0 195750.0 132285.0 95627.0 83726.0 True False 183367.47563605566 106777.09681497555 108231.66077632857 99861.12716680147 71019.04059716713 99627.42165499585 204852.76287126646 132669.92744903947 114755.0720416239 81308.61283372717 2.2552035909287342 1.3132323021342205 1.3311217225862402 1.228174035769291 0.8734504023872379 1.225299733728454 2.519447272949818 1.6316835674019445 1.4113519840301962 1.0 16.311120561300804 AEGAATEEEGT(ph)PKESEPQAAAEPAEAK ddPTM_A459_Selumetinib_30min_R2 1 AEGAATEEEGTPKESEPQAAAEPAEAK 27 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 AEGAAT(0.176)EEEGT(0.647)PKES(0.176)EPQAAAEPAEAK 51.58600000000001 0.031905 11722000.0 46293.0 43042.0 45215.0 23903.0 21672.0 22864.0 31550.0 19577.0 11660.0 34354.0 True False 43720.22038556191 46343.18299815659 42305.91612636976 20647.370165025084 18949.369609861784 26013.3084612729 33017.13751513896 19633.96582885318 13992.325807620626 33362.110757588525 1.3104752485007962 1.3890962515798073 1.2680827191590953 0.6188868059053682 0.5679907289904184 0.77972609857594 0.9896597297168586 0.5885109000301262 0.41940769003765566 1.0 15.025922947803611 -5.719787390811017 6.146161752488124 0.7005760885195453 1.3379373354386115 0.7236667948768764 0.17374932646713342 0.09832227919965922 9.281864812053911 0.04915762967620142 0.08440685962078537 1.9063937660538333e-06 5.719787390811017 0.6373612469190661 AEGAATEEEGTPKES(ph)EPQAAAEPAEAK ddPTM_A459_Selumetinib_30min_R1 2 AEGAATEEEGTPKESEPQAAAEPAEAK 27 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 AEGAATEEEGT(0.005)PKES(0.995)EPQAAAEPAEAK;AEGAAT(0.002)EEEGT(0.036)PKES(0.962)EPQAAAEPAEAK 160.98 1.9055e-17 41976000.0 6113.7 6128.9 9433.1 8660.5 6619.4 8185.0 5852.1 5714.2 3512.8999999999996 4815.5 True False 6256.137314810648 5411.325538751694 8152.136832309296 7148.106252719365 6020.67643874999 8102.66633138539 5410.671385447258 5562.640853662518 5961.134727935362 5433.616331942139 1.1513763454429464 0.9958976137016876 1.5003151371557135 1.3155338573867277 1.1080422449698464 1.4912106112006718 0.9957772236585796 1.0237456076833935 1.0970842186431429 1.0 12.407696985012945 -7.3122954565080205 24.997997517966873 1.031130427283566 1.254860157545054 0.3620955304628145 0.15024661665573028 435.2923081572426 213963.64955666094 0.06405682751282993 0.043187184348288235 4.87196930562612e-08 7.3122954565080205 0.223729730261488 AEGAATEEEGTPKES(ph)EPQAAAEPAEAK ddPTM_A459_Selumetinib_30min_R2 1 AEGAATEEEGTPKESEPQAAAEPAEAK 27 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 AEGAAT(0.224)EEEGT(0.308)PKES(0.468)EPQAAAEPAEAK 51.956 0.011595 12991000.0 38956.0 42191.0 39471.0 29987.0 15521.0 15968.0 22334.0 22787.0 6742.3 31278.0 True False 36790.98147322383 45426.914034552865 36931.4788327754 25902.718869539676 13571.113220499483 18167.44705692817 23372.57525398142 22853.306397409076 8090.948395602106 30374.92286999632 1.211228803137642 1.4955400620761599 1.2158542423577807 0.8527665726231625 0.446786754935425 0.5981067716512154 0.7694694519559862 0.7523741375482823 0.2663693478410168 1.0 14.890593124886301 -5.810890589070274 2.7514615406240845 0.631437974329238 1.352673216417565 0.6989775382211847 0.1966804243085194 0.13564648776065555 2.0893133795905054 0.05584907450845238 0.09585095612719831 1.545643781402454e-06 5.810890589070274 0.721235242088327 AEGDSAGTAGT(ph)PGGTPAGDK ddPTM_A459_Selumetinib_30min_R2 2 AEGDSAGTAGTPGGTPAGDK 20 0 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 AEGDS(0.002)AGTAGT(0.916)PGGT(0.081)PAGDK;AEGDSAGT(0.001)AGT(0.935)PGGT(0.064)PAGDK 236.66 1.5810999999999995e-29 11266100.0 62506.0 50867.0 55578.0 66512.0 68699.0 57745.0 64903.0 71950.0 59775.0 57856.0 True False 59032.166751343226 54768.33533681589 52002.17198875105 57452.95086040033 60068.41744314758 65698.8495930809 67921.11810285466 72159.36258803633 71731.6702530466 56185.5469520592 1.050664627358935 0.9747762246320649 0.9255435749895314 1.0225574721097321 1.0691079948799194 1.169319391856041 1.2088717078932938 1.2843047100637273 1.2766925685399533 1.0 15.77791144198432 -6.641591026784672 1.7135790191502676 1.2159360098122804 0.9845332190293942 0.566205044612282 0.0799404038902536 0.23317566396901684 1.4091360420043808 0.031412999741156064 0.031390022662109704 2.2824904715728322e-07 6.641591026784672 -0.23140279078288628 AEGEPQEES(ph)PLK ddPTM_A459_Selumetinib_30min_R1 4 AEGEPQEESPLK 12 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEPQEES(1)PLK;AEGEPQEES(1)PLK;AEGEPQEES(1)PLK;AEGEPQEES(1)PLK 192.39 0.00010416 120825000.0 17507.800000000003 21126.0 12375.0 12035.9 12358.3 14038.4 17309.9 16516.6 10069.4 17895.2 True False 17915.697675751493 18652.55809878906 10694.542971009272 9934.056006824669 11240.493947035073 13897.18644184736 16004.20030671956 16078.526114522128 17087.03636012194 20192.223234009147 0.8872573103082888 0.9237495981806068 0.529636724350233 0.491974355260348 0.5566744095867091 0.6882444929808794 0.7925922827439909 0.7962731952884493 0.8462186735011311 1.0 14.301512144706088 -8.221368543384914 0.9804786014623669 0.985561279723479 0.6750999829228655 0.3467515889253868 0.1354977998086915 0.6602968832825075 1.2936259766551559 0.14545536184781674 0.051218207627186985 6.006637963434417e-09 8.221368543384914 -0.3104612968006134 AEGEPQEES(ph)PLK ddPTM_A459_Selumetinib_30min_R2 4 AEGEPQEESPLK 12 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEPQEES(1)PLK;AEGEPQEES(1)PLK;AEGEPQEES(1)PLK;AEGEPQEES(1)PLK 135.14 0.0015151 219897000.0 346812.0 251842.0 293035.0 308965.0 309465.0 244245.0 359337.0 334879.0 287172.0 254280.0 True False 327537.577438436 271157.4716003382 274181.4471323843 266883.43400564644 270587.2400477981 277887.531714643 376046.8825127574 335853.44244779745 344614.42425609176 246938.27570121692 1.3263945271681585 1.0980779339709381 1.1103238100849553 1.080769812811693 1.0957687271421432 1.1253319515799696 1.5228375651563855 1.3600704123088778 1.395548840201096 1.0 17.91379094754982 -7.225572808207691 24.45944605937658 1.349620083447487 1.1315881512880337 0.2719983078645818 0.1406721282906793 481.0135439871784 328030.58866225387 0.050943133217176015 0.03945904447291584 5.948770189955114e-08 7.225572808207691 -0.21803193215945327 AEGEPQEES(ph)PLKSK ddPTM_A459_Selumetinib_30min_R1 1 AEGEPQEESPLKSK 14 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEPQEES(1)PLKSK 197.45 0.0004981 19963000.0 2239.2 2231.0 2396.7 2751.1 1728.3 2048.7 1859.4 2084.6 1431.4 1624.2 True False 2291.369003275266 1969.793482836239 2071.2413041307404 2270.6720295428954 1571.9755701561485 2028.0919380707676 1719.1439609884726 2029.309636264899 2428.981254680372 1832.6818910477475 1.2502819035142463 1.0748147250530775 1.1301695696608909 1.238988632252348 0.857746004822172 1.1066251857332992 0.938048206503331 1.10728962084344 1.325369812702039 1.0 10.839740675539627 -1.5228846720034483 0.9299191507424173 1.0768301396235564 98.59393614321 0.11819615090785429 0.12915353128631774 2539.12147845753 4.873114957920905 0.042525335061521265 526226.5624500609 0.029999590599264953 1.5228846720034483 97.51710600358645 AEGEPQEES(ph)PLKSK ddPTM_A459_Selumetinib_30min_R2 2 AEGEPQEESPLKSK 14 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEPQEES(0.715)PLKS(0.285)K;AEGEPQEES(0.98)PLKS(0.02)K 72.359 0.028644 63855000.0 105207.0 112147.0 97264.0 97328.0 93146.0 69885.0 83380.0 70649.0 49056.0 98318.0 True False 99360.01611698997 120748.31429055957 91006.14013303605 84071.75849983518 81444.16674419465 79511.02439713333 87257.33521433554 70854.57689342849 58868.57073916273 95479.30387915771 1.0406445384514307 1.2646543217720072 0.9531504361219153 0.880523370868305 0.8530033571178266 0.8327566411435671 0.9138874255385417 0.7420935638900842 0.6165584409126931 1.0 16.542900427601438 -5.542496841952098 2.6218267568404814 0.8252811546605187 1.152767896072447 0.5644346161747471 0.10988287008440964 0.190846574975492 2.6229288048817088 0.03107280903455631 0.06868487159117162 2.8674982270178683e-06 5.542496841952098 0.32748674141192835 AEGEPQEESPLKS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 AEGEPQEESPLKSK 14 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEPQEES(0.286)PLKS(0.714)K 80.738 0.018343 30676000.0 3424.7 3379.5 4678.4 4206.5 3036.2 3626.8 3295.6 3214.3 1896.7 2681.5 True False 3504.4888466938232 2983.8265689130744 4043.098976611698 3471.9137407844823 2761.576246084648 3590.3176848709268 3047.0102386972194 3129.046322482138 3218.561370512967 3025.696645021879 1.1582419713026064 0.9861618393973195 1.336253911397143 1.1474758206500166 0.9127075745112178 1.1866086082284582 1.0070441938422372 1.0341573163424358 1.0637422544683734 1.0 11.56305163551447 -6.038423901022684 24.825200475470975 1.0409442183882955 1.1593220923179697 0.260953449105799 0.10116556376964676 727.3412264378344 469924.7735566062 0.02934131775112564 0.03788863456999889 9.153266327634598e-07 6.038423901022684 0.11837787392967414 AEGEPQEESPLKS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 AEGEPQEESPLKSK 14 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEPQEES(0.305)PLKS(0.695)K 62.438 0.045099 52101000.0 101090.0 107150.0 115060.0 108550.0 96962.0 59049.0 77167.0 72849.0 51191.0 99731.0 True False 95471.82249533315 115368.06045844693 107657.16486785581 93765.30274080546 84780.76670872184 67182.46375654769 80755.4184035097 73060.97852919878 61430.63039604699 96851.50689774299 0.9857546418573897 1.1911849815641375 1.1115693324371458 0.9681346810618447 0.875368586657453 0.6936646202880432 0.8338065249596195 0.7543607824949741 0.6342764543757301 1.0 16.563486875223496 -6.177001430445244 1.8706407860352459 0.7721547675921137 1.1053736537454644 0.6285860845840767 0.1039081371648819 0.2014684104519849 1.3899528658793139 0.03395927623143161 0.0476344703032574 6.652709649805897e-07 6.177001430445244 0.3332188861533507 AEGEWEDQEALDY(ph)FSDKESGK ddPTM_A459_Selumetinib_30min_R1 1 AEGEWEDQEALDYFSDKESGK 21 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEWEDQEALDY(0.511)FS(0.487)DKES(0.002)GK 106.7 0.0012486 114180000.0 2170.9 2216.3 2377.5 2477.5 1662.5 1940.6 1851.3 2173.6 1137.8 1998.1 True False 2221.4777461639324 1956.8145656700833 2054.648558672689 2044.8511334348173 1512.1271685382144 1921.0793259238221 1711.6549505098194 2115.949067152155 1930.7634983759453 2254.5755981421635 0.985319697416443 0.8679303400970702 0.9113238697188862 0.9069782956578767 0.670692599433903 0.8520802440631611 0.7591916420634879 0.9385132478572725 0.8563755857053323 1.0 11.13864017043537 -3.66047712388312 0.9220122842614682 0.8458546185137563 1.8188787993978741 0.13914977950903684 0.08814115707488186 25.64100944819488 3.505799471306387 0.029053179202422258 40.35729268349326 0.00021853594286937156 3.66047712388312 0.9730241808841178 AEGEWEDQEALDYFS(ph)DKESGK ddPTM_A459_Selumetinib_30min_R1 4 AEGEWEDQEALDYFSDKESGK 21 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEWEDQEALDY(0.037)FS(0.93)DKES(0.033)GK;AEGEWEDQEALDY(0.001)FS(0.994)DKES(0.005)GK;AEGEWEDQEALDYFS(0.995)DKES(0.005)GK;AEGEWEDQEALDY(0.321)FS(0.659)DKES(0.02)GK 142.32 7.1247000000000014e-06 483245100.0 19051.1 21094.600000000002 22277.399999999998 21925.0 15581.6 17359.6 17738.600000000002 17458.78 11038.569999999998 17126.1 True False 19494.953563012426 18624.834425386518 19252.251440998934 18096.210333222334 14172.247031154917 17184.97818525569 16400.563120571205 16995.71644029016 18731.64706474579 19324.40175734073 1.0088257224111432 0.9637987586503955 0.996266362227002 0.9364434956620665 0.7333860685116075 0.8892890140170917 0.8486970684275466 0.8794950888367877 0.9693261038536538 1.0 14.238136131599845 -6.004853677224167 23.818157771296608 0.8749041296673183 0.9835984829620026 0.30466866348710575 0.06833416227560891 129.10555419951854 633566.3597137678 0.01916290381397909 0.02754106951027275 9.888862147149961e-07 6.004853677224167 0.10869435329468424 AEGEWEDQEALDYFS(ph)DKESGK ddPTM_A459_Selumetinib_30min_R2 4 AEGEWEDQEALDYFSDKESGK 21 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 AEGEWEDQEALDY(0.149)FS(0.805)DKES(0.045)GK;AEGEWEDQEALDY(0.002)FS(0.988)DKES(0.009)GK;AEGEWEDQEALDY(0.035)FS(0.94)DKES(0.025)GK;AEGEWEDQEALDY(0.44)FS(0.557)DKES(0.003)GK 101.76 0.00012829 141263500.0 224979.0 180438.0 179534.0 206148.0 166304.0 150446.0 195648.0 191341.0 135282.0 186643.0 True False 212475.56784229417 194277.01440038538 167982.97790183921 178070.28677486465 145411.40474337654 171168.57088718802 204746.019669157 191897.77063179226 162342.18009490025 181254.13163324777 1.1722522732459435 1.0718487498728486 0.9267815105133074 0.9824343598146201 0.8022515317753092 0.9443567953172675 1.1296074623194965 1.0587221869241634 0.8956605768490054 1.0 17.46765435573741 -4.982774008811375 3.1448325931893253 0.9694532291259225 1.1703352185174531 0.3755582274637034 0.08430183581417174 0.30980978918178553 5.901184549419039 0.02386580559438845 0.12181518110407134 1.0404614436044994e-05 4.982774008811375 0.20088198939153068 AEGFVDALHR ddPTM_A459_Selumetinib_30min_R2 2 AEGFVDALHR 10 0 Q96I24;A0A494C1K6 Q96I24 FUBP3 Far upstream element-binding protein 3 0 ; 116.77 0.008757700000000002 4852600.0 85420.0 76123.0 80409.0 98738.0 95576.0 70420.0 67430.0 74821.0 67499.0 82232.0 False True 80672.69836335306 81961.38932597631 75235.57248269966 85289.71406744972 83568.8884197191 80119.71579088691 70565.6286100102 75038.71672271674 81000.6860796386 79857.74849560497 1.0102050193387675 1.0263423508676446 0.9421198806630555 1.0680205199141533 1.0464718827418276 1.0032804242570945 0.8836415994609944 0.9396548003960635 1.014312168894876 1.0 16.28514477683953 -7.0214896125985256 24.51180636273111 0.9528144582396222 1.0182857064533715 0.2771037250940328 0.04490652179670215 748.4089413772851 853659.2261775016 0.017296782187693056 0.013538029416896484 9.517226110239194e-08 7.0214896125985256 0.06547124821374928 AEGLEEADTGASGCHSHPEEQPTS(ph)ISPSR ddPTM_A459_Selumetinib_30min_R2 2 AEGLEEADTGASGCHSHPEEQPTSISPSR 29 0 Q9BV36;Q9BV36-4;Q9BV36-2;Q9BV36-3 Q9BV36;Q9BV36-2 MLPH Melanophilin 1 AEGLEEADTGASGCHSHPEEQPT(0.034)S(0.325)IS(0.321)PS(0.321)R;AEGLEEADTGASGCHSHPEEQPT(0.26)S(0.318)IS(0.318)PS(0.103)R 121.91 7.035e-14 98369000.0 121290.0 95877.0 157823.0 174850.0 203667.0 157182.0 112295.0 113036.0 123853.8 163263.0 True False 114549.18736233989 103230.45760685526 147668.8400046902 151035.12836692628 178080.5306539185 178832.3937438678 117516.94000832114 113364.91604588291 148628.02076431282 158549.1729817829 0.7224836636360219 0.6510942672574918 0.9313756560663811 0.9526074814926977 1.123188013565859 1.1279301580741479 0.741201847970684 0.7150142376265084 0.9374253928236509 1.0 17.274570826566723 -5.267678759867818 23.368133464779692 0.9373632396427978 0.6867889528850122 0.3844344668513451 0.12864866987152282 214.1111920937148 801912.4436049632 0.03809822864665262 0.08286785922846077 5.399098368382218e-06 5.267678759867818 -0.2505742867577856 AEGLEEADTGASGCHSHPEEQPTSIS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 4 AEGLEEADTGASGCHSHPEEQPTSISPSR 29 0 Q9BV36;Q9BV36-4;Q9BV36-2;Q9BV36-3 Q9BV36;Q9BV36-2 MLPH Melanophilin 1 AEGLEEADTGASGCHSHPEEQPT(0.018)S(0.052)IS(0.754)PS(0.176)R;AEGLEEADTGASGCHSHPEEQPT(0.008)S(0.02)IS(0.486)PS(0.486)R;AEGLEEADTGASGCHSHPEEQPT(0.014)S(0.038)IS(0.802)PS(0.145)R;AEGLEEADTGASGCHS(0.001)HPEEQPT(0.142)S(0.117)IS(0.633)PS(0.107)R 149.64 6.305500000000002e-16 121875000.0 10149.51 11078.509999999998 8389.6 9351.47 13440.649999999998 9344.060000000001 11977.76 9486.07 3305.43 6464.370000000001 True False 10385.973835491406 9781.432898940424 7250.338400774091 7718.411313332662 12224.945580639482 9250.06724012767 11074.267919850095 9234.468608502038 5609.0732909446315 7294.1348577960425 1.4238801500072042 1.3409997332974908 0.9939956611886409 1.0581667961736612 1.6759966492219898 1.2681513874453676 1.5182428260170993 1.2660128704135691 0.7689840399577476 1.0 12.832521157886292 -8.192546439391322 6.12838569616555 0.8867764422305703 1.3184896158072077 0.44073595813925315 0.1957711247655047 0.20200311212836417 13.92619263341316 0.14380999165466343 0.05239868403538143 6.418795812372646e-09 8.192546439391322 0.4317131735766374 AEGLEEADTGASGCHSHPEEQPTSIS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 5 AEGLEEADTGASGCHSHPEEQPTSISPSR 29 0 Q9BV36;Q9BV36-4;Q9BV36-2;Q9BV36-3 Q9BV36;Q9BV36-2 MLPH Melanophilin 1 AEGLEEADTGASGCHSHPEEQPT(0.008)S(0.021)IS(0.485)PS(0.485)R;AEGLEEADTGASGCHSHPEEQPT(0.033)S(0.088)IS(0.623)PS(0.256)R;AEGLEEADTGASGCHSHPEEQPT(0.001)S(0.003)IS(0.854)PS(0.142)R;AEGLEEADTGASGCHSHPEEQPT(0.018)S(0.048)IS(0.467)PS(0.467)R;AEGLEEADTGASGCHSHPEEQPT(0.071)S(0.071)IS(0.428)PS(0.428)R 132.9 6.1551e-14 181798000.0 212450.0 146697.59999999998 260368.0 302971.0 343704.0 244367.7 187958.8 221990.0 241292.0 287683.0 True False 200642.87950473375 157948.83421287077 243616.20634724357 261705.827145874 300524.8307672541 278027.1325258835 196699.25663329658 222635.95414757702 289557.14226178324 279376.84429979994 0.7181800625159307 0.5653612224332218 0.8719985615050417 0.9367484545893033 1.0756969909960048 0.995168848809574 0.7040642796516742 0.7969019576606924 1.036439304722974 1.0 18.09185292468227 -5.375037748111136 4.83676619311986 0.9237144552448938 0.6437218921457767 0.5166010189640142 0.11119347334988355 0.18501617884513918 6.537172930000706 0.03178215844264597 0.06894943026099135 4.216598519044031e-06 5.375037748111136 -0.27999256309911713 AEGSSTAS(ph)SGSQLAEGK ddPTM_A459_Selumetinib_30min_R1 2 AEGSSTASSGSQLAEGK 17 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DH52;Q9NZB2-2;Q9NZB2-5 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 AEGS(0.001)S(0.005)T(0.054)AS(0.616)S(0.162)GS(0.162)QLAEGK;AEGSST(0.005)AS(0.596)S(0.341)GS(0.058)QLAEGK 263.47 1.6019999999999997e-40 9739700.0 4472.0 4973.9 5089.1 5196.4 4813.3 4224.1 5287.8 4323.5 2343.3999999999996 4237.0 True False 4576.188899002767 4391.553475696623 4398.028172425316 4288.94628850885 4377.937864857138 4181.609389175935 4888.936988767797 4208.826735292761 3976.5786448358135 4780.860221874956 0.9571894359229101 0.91856972843568 0.919924023777566 0.8971076520674375 0.9157217868085256 0.874656274208325 1.0226061340171237 0.8803492551476741 0.8317705308849797 1.0 12.223054510854759 -4.74937524689798 3.8919410382995925 0.9150826811052379 0.9627831057036684 0.04413880396563663 0.05376016352100382 1.0116988803914262 26.948212144873526 0.01320529574705318 0.14416178274421093 1.7808393897529468e-05 4.74937524689798 0.04770042459843049 AEGSSTASS(ph)GSQLAEGK ddPTM_A459_Selumetinib_30min_R2 1 AEGSSTASSGSQLAEGK 17 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DH52;Q9NZB2-2;Q9NZB2-5 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 AEGSSTAS(0.26)S(0.566)GS(0.173)QLAEGK 152.68 0.00015978 4123000.0 17882.0 14932.0 14971.0 19733.0 18268.0 15449.0 15737.0 13300.0 10154.0 15811.0 True False 16888.19002731769 16077.236386052557 14007.78215919234 17045.331358676318 15973.0105220079 17576.959517941086 16468.801682273912 13338.700798066471 12185.08372646482 15354.495348088501 1.0998857106313247 1.047070321855549 0.912291927649461 1.1101199337559675 1.0402823511875563 1.1447435503068657 1.0725719933429223 0.8687163267614015 0.7935841231005847 1.0 13.906373475987339 -7.763100604790071 24.99936576025504 0.8733626142483789 1.0590540671534727 0.5268321686942956 0.07500580703192682 32.90324088061017 495121.5505041006 0.03859547637747799 0.02008006435557588 1.7254381460641083e-08 7.763100604790071 0.1856914529050938 AEGSSTASSGS(ph)QLAEGK ddPTM_A459_Selumetinib_30min_R2 1 AEGSSTASSGSQLAEGK 17 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DH52;Q9NZB2-2;Q9NZB2-5 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 AEGSS(0.001)T(0.008)AS(0.123)S(0.306)GS(0.562)QLAEGK 105.0 0.0027007 3859900.0 15549.0 14862.0 16211.0 17650.0 18161.0 14127.0 13918.0 17014.0 10839.0 15648.0 True False 14684.84882757873 16001.867611138028 15168.00190920225 15246.039552051723 15879.45281860003 16072.866017862245 14565.214577993804 17063.507923180678 13007.102866963969 15196.20158161335 0.9663499624371046 1.0530175929292418 0.9981442946607645 1.0032796334117253 1.0449619750907608 1.057689708282734 0.9584773207810688 1.122879808584974 0.8559443487971309 1.0 13.891423134521366 -8.271254375101003 24.999534309724744 0.9279721926565504 1.0243323816925503 0.32758211669346926 0.055925519872912166 831.1168363887184 2116892.773083182 0.046686431658218217 0.012669805722037596 5.354829224154854e-09 8.271254375101003 0.09636018903599985 AEGYEVAHGGR ddPTM_A459_Selumetinib_30min_R1 2 AEGYEVAHGGR 11 0 A8MU39;H0YDU8;P53041 A8MU39 PPP5C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 5 0 ; 147.62 0.00093186 5956600.0 7413.0 6517.0 8354.5 8287.0 8151.5 7441.8 7339.799999999999 7491.2 3976.7 5907.5 False True 7585.708476812948 5753.986610328898 7220.004787983589 6839.831016256029 7414.198264264213 7366.942248613782 6786.152976693121 7292.509041153029 6748.169453323625 6665.7851689228955 1.1380067440785375 0.8632121294810147 1.083143936537974 1.0261103295294554 1.11227681006441 1.1051874703312985 1.0180575588201375 1.0940210127311085 1.0123592768613097 1.0 12.702559106352078 AEGYEVAHGGR ddPTM_A459_Selumetinib_30min_R2 2 AEGYEVAHGGR 11 0 A8MU39;H0YDU8;P53041 A8MU39 PPP5C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 5 0 ; 107.03 0.015149 5913500.0 58115.0 49661.0 68830.0 69720.0 67260.0 53036.0 58321.0 62041.0 51337.0 52575.0 False True 54885.200952777544 53469.83901471706 64401.552736437756 60224.015726291655 58810.197487970785 60341.227587126894 61033.04206086915 62221.52903855953 61605.83447562778 51057.02314374505 1.0749784764821622 1.047257276715468 1.2613652103281219 1.1795442040703785 1.1518532391204552 1.1818399090217864 1.1953897486157348 1.2186673880962884 1.2066084288185739 1.0 15.639821804075638 -5.240668488314337 24.919812696272036 1.1826106753285048 1.0611178460830961 0.31779320144835843 0.06551982431249762 796.2523661426578 955297.9040528316 0.015397665294254074 0.04064435463707025 5.745548720509593e-06 5.240668488314337 -0.12149282924540872 AEHENLFR ddPTM_A459_Selumetinib_30min_R2 2 AEHENLFR 8 0 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 0 ; 136.8 0.0036134 1470800.0 21484.8 19450.5 21992.6 25297.7 26342.6 19360.0 18408.1 22780.8 19449.9 22473.6 False True 20290.76082646881 20942.29080678509 20577.620059732388 21852.109619033374 23033.207082168006 22026.664267417917 19264.11312495815 22847.088356435543 23340.4234756124 21824.728774574764 0.9297142262820244 0.9595670591417526 0.9428579971039446 1.001254578910988 1.0553719736944034 1.00925260033831 0.8826736553720812 1.0468440910501395 1.0694485011334198 1.0 14.41367610451494 -5.788993166469277 5.836114230877253 1.008200056001017 0.9453583231244633 0.2733700126839316 0.048756289997691334 0.25847705852812797 25.650549653173098 0.014651543723611866 0.022817691427696584 1.6255743336134783e-06 5.788993166469277 -0.06284173287655359 AEHMETNAVGPS(ph)PSSDTR ddPTM_A459_Selumetinib_30min_R1 5 AEHMETNAVGPSPSSDTR 18 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEHMETNAVGPS(0.993)PS(0.006)SDTR;AEHMETNAVGPS(0.489)PS(0.489)S(0.021)DTR;AEHMET(0.001)NAVGPS(0.993)PS(0.004)S(0.001)DTR;AEHMETNAVGPS(0.994)PS(0.006)SDTR;AEHMETNAVGPS(0.999)PS(0.001)SDTR 354.93 4.458399999999997e-184 80959000.0 9766.3 11832.16 10189.650000000001 10389.34 10973.54 9324.51 10460.23 9642.96 5811.7 8666.25 True False 9993.835788088267 10446.84520657805 8805.951497740978 8575.03680106546 9980.985244535837 9230.713895377688 9671.206429520516 9387.1973760515 9862.030430226301 9778.647603923493 1.0220059248354991 1.0683323123727717 0.9005285653414651 0.8769143902501295 1.0206917816049697 0.9439663099909688 0.9890126754992308 0.959968878752218 1.0085270304933938 1.0 13.255419237567018 -8.269771585460031 23.318274273786646 1.0042635258966126 0.9714569519879029 0.05086222201580659 0.05437417133018946 999.0317828142479 2795773.774665248 0.051872364292421924 0.014374761007928111 5.373143192646698e-09 8.269771585460031 -0.03280657390870967 AEHMETNAVGPS(ph)PSSDTR ddPTM_A459_Selumetinib_30min_R2 2 AEHMETNAVGPSPSSDTR 18 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEHMET(0.002)NAVGPS(0.928)PS(0.061)S(0.009)DTR;AEHMETNAVGPS(0.874)PS(0.11)S(0.012)DT(0.005)R 269.99 5.534400000000001e-54 26273000.0 17530.9 19184.4 22919.0 26901.0 21554.6 17829.9 22990.8 18330.1 19232.9 20095.8 True False 16556.602759753052 20655.781792431444 21444.41649232044 23237.0373931866 18846.718447431107 20285.8068812828 24059.917755405942 18383.43755628859 23080.0174121258 19515.582038841098 0.848378630306854 1.0584250959731076 1.098835609905995 1.190691486779069 0.9657266900839147 1.039467172483442 1.2328567863115962 0.9419876650207386 1.1826456093490088 1.0 14.252338870357455 -4.76210301921238 4.139972214860091 1.0829672396034264 0.8244288636586018 0.35788989848787345 0.09309227577760816 0.2508896963212872 8.408725763272432 0.022171270515043813 0.1988391664252345 1.7294060772704395e-05 4.76210301921238 -0.25853837594482465 AEHMETNAVGPSPS(ph)SDTR ddPTM_A459_Selumetinib_30min_R2 2 AEHMETNAVGPSPSSDTR 18 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 AEHMETNAVGPS(0.229)PS(0.34)S(0.34)DT(0.092)R;AEHMETNAVGPS(0.074)PS(0.852)S(0.074)DTR 281.36 4.6231999999999986e-67 31483200.0 28316.0 33411.0 33405.0 44103.0 42236.0 30837.0 35811.0 37772.0 32517.0 38344.0 True False 26742.310077929076 35973.516266702514 31255.758668614006 38096.09531808144 36929.93608536928 35084.51683958505 37476.2824581503 37881.91026650879 39021.30860089195 37236.909090323505 0.7181667525911385 0.9660714905053894 0.8393757546524242 1.0230735108994642 0.9917562168167713 0.9421973438902376 1.0064283898334891 1.017321555197311 1.0479201833385292 1.0 15.184445704188095 -3.7446003063838895 0.6365137674323945 1.0067011185699062 8.960432437685089e-18 0.6884876989249458 0.05380063406314165 6.452375904214119 0.7311418666706954 0.02280580192725236 6.391063582455649 0.00018005272294715192 3.7446003063838895 -1.0067011185699062 AEIDMLDIR ddPTM_A459_Selumetinib_30min_R1 1 AEIDMLDIR 9 0 P09525;Q6P452;P09525-2 P09525 ANXA4 Annexin A4;Annexin 0 127.68 0.042483 0.0 1943.5 2796.2 2153.0 2600.0 2240.8 2456.0 2232.5 2186.4 1072.0 1900.6 False True 1988.7797686073072 2468.8196040818866 1860.6344255824604 2145.958808044609 2038.120035645372 2431.294869869578 2064.1007276039372 2128.4095695718943 1819.1057042178 2144.560523411741 0.9273600567091457 1.1512007132138606 0.867606395469041 1.0006520145351943 0.9503672260100009 1.1337030796415466 0.9624819188223227 0.9924688747817886 0.8482417186920045 1.0 11.066466316697037 -8.041924300847697 21.29101817205787 0.9228651681223287 1.001378433314546 0.10010864671157449 0.08886183492495829 192.79379625718138 97904.46319899707 0.05668923366247588 0.021439288150932524 9.079787804829321e-09 8.041924300847697 0.07851326519221724 AEISFEDRK ddPTM_A459_Selumetinib_30min_R2 1 AEISFEDRK 9 1 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 96.034 0.029555 16308000.0 75484.0 72328.0 82744.0 83211.0 86608.0 56963.0 58834.0 62471.0 57250.0 90608.0 False True 71288.90146639363 77875.32502882477 77420.34112485552 71877.51825301856 75727.52875465633 64809.136191370235 61569.897577359305 62652.78026736924 68701.59969865195 87991.91161214345 0.810175619102646 0.8850282213675361 0.8798574744700854 0.8168650610733975 0.8606192020063518 0.7365351542428151 0.6997222409344982 0.7120288571924008 0.7807717600394839 1.0 16.425083294056712 -6.75457638078763 24.945773952787412 0.7624328191589395 0.8521882073834658 0.1007980926170331 0.08297365365367168 238.66537586485262 867505.3110000164 0.02625685567809448 0.025701289492653313 1.7596391631045225e-07 6.75457638078763 0.08975538822452633 AEISS(ph)IR ddPTM_A459_Selumetinib_30min_R1 2 AEISSIR 7 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 AEIS(0.079)S(0.921)IR;AEIS(0.006)S(0.994)IR 95.815 0.023547 20842100.0 13871.8 17284.5 10354.1 9416.1 11754.8 13130.3 19486.2 16461.4 10014.1 13502.900000000001 True False 14194.985950175895 15260.822704653958 8948.070091000169 7771.754897088025 10691.580415478498 12998.221103358524 18016.340245570387 16024.790197836992 16993.196299074138 15236.128744384081 0.931666185572766 1.0016207503024006 0.5872928905446771 0.5100872424665376 0.7017255232513923 0.8531183558126317 1.1824749283646656 1.0517625879043326 1.1153224407701134 1.0 13.89520876330236 -7.080584776662368 4.171183471845465 1.0898118979854585 0.7407437898205494 0.5609163699810538 0.14233893811846698 0.19327396040683623 6.200917007580898 0.06307983491491519 0.04904834936177443 8.306445565064209e-08 7.080584776662368 -0.3490681081649091 AEISS(ph)IR ddPTM_A459_Selumetinib_30min_R2 3 AEISSIR 7 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 AEIS(0.027)S(0.973)IR;AEIS(0.089)S(0.911)IR;AEIS(0.384)S(0.616)IR 90.601 0.029436 43937500.0 134524.0 106678.0 123743.0 137336.0 136452.0 163850.0 163927.0 157039.0 154364.0 171675.0 True False 127047.69462223962 114859.85957616611 115781.5101011912 118630.59988218572 119309.6798636425 186418.85021779058 171549.93031518828 157495.95749079413 185241.11329052743 166718.2966847823 0.7620500997707006 0.6889457357720851 0.6944739263987424 0.7115631711766047 0.7156363892634037 1.118166715500078 1.0289808240995961 0.9446831009110833 1.111102482295429 1.0 17.3470529176207 -6.752058371467873 24.99993413492122 1.0364039559554985 0.7118327495594536 0.9126689778632614 0.05041783472396344 52.54479272037496 140029.1415073844 0.016486338434154944 0.01627410206878313 1.7698710623293918e-07 6.752058371467873 -0.32457120639604486 AEISS(ph)IRENK ddPTM_A459_Selumetinib_30min_R1 1 AEISSIRENK 10 1 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 AEIS(0.005)S(0.995)IRENK 139.31 0.0073191 10704000.0 3555.7 4254.2 3474.6 3960.5 3682.1 4137.5 4642.8 4450.8 2854.0 3430.9 True False 3638.540891812194 3756.116286276078 3002.7684046116196 3268.873022792568 3349.054705127553 4095.8805065494253 4292.589858060277 4332.750325764081 4843.029552087314 3871.2894347960305 0.9398782894164823 0.97024940902513 0.7756507115231566 0.8443886921528505 0.865100572182872 1.058014538963354 1.108826898727205 1.1192008241027744 1.2510120035348073 1.0 11.918598458614955 -6.882090345369817 3.1503103946992383 1.1267408160404235 0.8753742193763555 0.700345134698654 0.07529824458594966 0.14250587232766976 2.8169780216697142 0.029309197801234567 0.025535949812191955 1.3119269532186737e-07 6.882090345369817 -0.251366596664068 AEITFDDHK ddPTM_A459_Selumetinib_30min_R1 1 AEITFDDHK 9 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7 O75369-8 FLNB Filamin-B 0 96.665 0.035923000000000004 0.0 3231.0 3852.6 3701.9 3879.4 3653.0 3002.9 3812.8 3140.9 2150.1 3062.5 False True 3306.276013568411 3401.5358009748525 3199.20231308115 3201.9356153570225 3322.5867949895305 2972.6935524150476 3525.1974262971094 3057.5931289189384 3648.562662909227 3455.60170627615 0.9567873541570113 0.9843541270386857 0.9258018096445199 0.9265927868774886 0.9615074529437133 0.8602535260403326 1.020139971540863 0.8848222071906209 1.0558400455360977 1.0 11.754721226268163 -8.273353205221996 24.986561270901078 1.0279200292244959 0.9413142452297256 0.3759629740612247 0.045267777115071066 841.316983426729 1764453.4733858227 0.03929684553848834 0.010464802208478403 5.32901318509787e-09 8.273353205221996 -0.08660578399477026 AEITFDDHK ddPTM_A459_Selumetinib_30min_R2 4 AEITFDDHK 9 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7 O75369-8 FLNB Filamin-B 0 ;;; 162.64 0.0013269 26898300.0 211316.0 192435.0 205738.0 223872.0 223659.0 172926.0 181288.0 184068.0 147968.0 184780.0 False True 199571.9026849717 207194.1457239504 192501.04107059713 193380.2473992593 195560.95688317087 196744.98683406573 189718.25121535698 184603.607405902 177565.73457135595 179444.92128390275 1.1121624465995654 1.154639229918049 1.0727583689372746 1.0776579577491037 1.0898104860475304 1.096408777837698 1.057250602903387 1.0287480196435184 0.9895277798942345 1.0 17.453181566483458 -7.662292316058284 1.0169142625376482 0.9898282985281937 1.1049951889985425 0.8001981719517731 0.02157328003293593 0.25305459744893416 0.4760291547370929 0.02001759062075037 0.008561919006738604 2.1762444869857133e-08 7.662292316058284 0.11516689047034889 AEKDEPGAWEETFK ddPTM_A459_Selumetinib_30min_R2 1 AEKDEPGAWEETFK 14 1 F5H6X6;Q14697;Q14697-2;E9PKU7 F5H6X6 GANAB Neutral alpha-glucosidase AB 0 131.86 0.001572 0.0 18509.0 14124.0 18159.0 19355.0 16115.0 11704.0 11386.0 14142.0 11808.0 15691.0 False True 17480.343877397576 15207.265384182041 16990.669710024296 16718.815610762675 14090.489630072103 13316.119761666294 11915.471560930984 14183.150878665869 14169.929943086136 15237.960059885932 1.1471577434708429 0.9979856440374394 1.1150225911637863 1.0971820076346772 0.924696585021603 0.8738781115932375 0.7819597580058351 0.9307775334050876 0.929909901810847 1.0 13.895382158465246 -6.325890694189764 4.295977243383276 0.8925470992686165 1.0851326841134707 0.6660468671876458 0.0630664455100712 0.13237153732053125 4.8970876433740935 0.020000652605518095 0.023211139570341932 4.7218186784164664e-07 6.325890694189764 0.19258558484485422 AELEEMEEVHPS(ph)DEEEEDATK ddPTM_A459_Selumetinib_30min_R2 1 AELEEMEEVHPSDEEEEDATK 21 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 AELEEMEEVHPS(1)DEEEEDATK 98.188 0.00022286 8446800.0 30385.0 18179.0 26396.0 29542.0 29497.0 23988.0 32820.0 36497.0 27230.0 19727.0 True False 28696.323340792336 19573.270845301988 24697.710097791783 25518.328637207494 25791.323153474215 27292.12925861679 34346.19503159624 36603.20022759639 32676.760869769263 19157.43025309859 1.497921326695207 1.0217064912521938 1.2891974430546125 1.3320329658034415 1.346283025057739 1.4246237046433963 1.792839361951531 1.9106529291252963 1.7056964550077904 1.0 14.2256164328078 -7.02143480100023 3.159478356597273 1.6763703144883353 1.2847168384551035 0.21748652018523573 0.2550529909266675 0.2928875071945808 5.975531169759067 0.09754174039673529 0.07802618427167968 9.51842733962649e-08 7.02143480100023 -0.39165347603323175 AELEEMEEVHPS(ph)DEEEEDATKAEGFYQK ddPTM_A459_Selumetinib_30min_R2 1 AELEEMEEVHPSDEEEEDATKAEGFYQK 28 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 AELEEMEEVHPS(0.958)DEEEEDAT(0.041)KAEGFY(0.001)QK 64.152 0.00046475 3172900.0 12128.0 10862.0 11052.0 12282.0 12843.0 8166.4 8223.2 7171.1 6078.6 12410.0 True False 11453.974312230688 11695.080473165204 10340.926352507768 10609.170412368236 11229.547522123241 9291.247472801746 8605.59509396168 7191.966713760485 7294.48985027468 12051.691054947703 0.9504039109539214 0.9704099134174123 0.8580477466075105 0.8803055408570853 0.9317818944182992 0.770949689171406 0.7140570609324355 0.5967599634748265 0.6052669137481747 1.0 13.556947974586851 -6.924780295008173 2.755259020443102 0.6967079272419482 0.9168310140715757 0.39399707881482704 0.10969851941259104 0.24335945522811017 3.745170799183088 0.041863299383087596 0.03531612458276721 1.1891036302709968e-07 6.924780295008173 0.22012308682962756 AELGMGDSTS(ph)QSPPIKR ddPTM_A459_Selumetinib_30min_R1 1 AELGMGDSTSQSPPIKR 17 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 AELGMGDS(0.22)T(0.22)S(0.502)QS(0.058)PPIKR 57.537 0.036302 8207400.0 2235.0 3049.3 2998.9 3332.2 2921.9 2497.0 2578.1 2443.8 1646.4 2054.6 True False 2287.071151447044 2692.2865384188904 2591.665851778561 2750.2938231408643 2657.614660903345 2471.8824470946015 2383.631841359783 2378.982485418862 2793.8205517016654 2318.327923498769 0.9865175363092927 1.1613053145457315 1.1179030479291627 1.1863264878379165 1.1463497609486288 1.066235031739639 1.0281685421631201 1.026163064036495 1.2051015403745358 1.0 11.178868932173318 -6.775905571429492 23.20941221010489 1.064458456005928 1.1255967272539962 0.12353153938160966 0.07177613278176377 203.61832079252406 326679.0074706587 0.024890287680774774 0.02207467220333881 1.6753070981474196e-07 6.775905571429492 0.06113827124806814 AELGMGDSTSQS(ph)PPIK ddPTM_A459_Selumetinib_30min_R2 1 AELGMGDSTSQSPPIK 16 0 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 AELGMGDS(0.002)T(0.007)S(0.007)QS(0.984)PPIK 133.23 0.00053285 0.0 7269.2 6695.5 9160.0 9302.3 13304.0 9610.0 11864.0 12550.0 10454.0 10666.0 True False 6865.206964913196 7209.0233205742625 8570.655572653925 8035.310692637441 11632.632580730957 10933.6902691057 12415.69950807001 12586.51842223566 12545.092109165189 10358.044866403894 0.6627898462942899 0.6959830174086793 0.827439510370598 0.7757555403819312 1.123052924636498 1.0555747160903792 1.1986528025515777 1.2151442269824273 1.2111447933436683 1.0 13.338464092252128 -6.189382099002784 1.24121376339687 1.1692550765635767 0.6909812498934308 0.855660240275401 0.0787146891646968 0.1513930352637066 0.4757688891860352 0.029936664487113133 0.0464895002391161 6.465735000604416e-07 6.189382099002784 -0.47827382667014595 AELGMGDSTSQS(ph)PPIKR ddPTM_A459_Selumetinib_30min_R1 1 AELGMGDSTSQSPPIKR 17 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 AELGMGDS(0.001)T(0.01)S(0.03)QS(0.959)PPIKR 100.53 0.0022321 14267000.0 1859.5 2384.1 2437.1 2638.1 2128.8 1742.9 1891.8 1832.5 1155.7 1719.7 True False 1902.8227320428548 2104.968463661979 2106.1552060320555 2177.405358270188 1936.2504158701663 1725.3680084265843 1749.1000029030815 1783.8961472011063 1961.1384910116722 1940.440246296521 0.9806139280374842 1.0847891181805123 1.0854007022642487 1.1221192522809877 0.9978407835879763 0.8891631740372224 0.9013933854656813 0.9193254729723365 1.0106667776833917 1.0 10.922168292277082 -6.509517634578632 5.804604608425877 0.9366842595004796 1.069953211110014 0.5807710841591177 0.0494797366200438 0.11284048180818168 13.821119404557002 0.016201152258478096 0.0173723370773545 3.093729691642369e-07 6.509517634578632 0.13326895160953445 AELGMGDSTSQS(ph)PPIKR ddPTM_A459_Selumetinib_30min_R2 3 AELGMGDSTSQSPPIKR 17 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 AELGMGDSTS(0.003)QS(0.996)PPIKR;AELGMGDSTS(0.012)QS(0.987)PPIKR;AELGMGDS(0.001)T(0.001)S(0.005)QS(0.994)PPIKR 94.176 0.0035581 48222000.0 76100.0 73010.0 86198.0 80075.0 87759.0 62157.0 59891.0 68244.0 57275.7 82021.0 True False 71870.66665243695 78609.6322358488 80652.11452528638 69168.64686292027 76733.92984458568 70718.56254493262 62676.05017176506 68442.57874159754 68732.44041676985 79652.84061384911 0.902298852100711 0.9869030612096095 1.0125453644055418 0.8683763985046634 0.9633545929213738 0.8878347840445617 0.786865222743452 0.8592609907461045 0.8629000533700922 1.0 16.281438192228315 -6.890377044620592 4.933566385186478 0.8619796975962674 0.9479220363175447 0.20968902860614425 0.0625604803216767 0.2695484957944401 10.58722826476298 0.021928787689447452 0.01929824044205874 1.287131608003187e-07 6.890377044620592 0.08594233872127732 AELGSWS(ph)SQEHLEWEPACQTPQPSAR ddPTM_A459_Selumetinib_30min_R2 1 AELGSWSSQEHLEWEPACQTPQPSAR 26 0 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6;H3BTL6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 AELGS(0.026)WS(0.487)S(0.487)QEHLEWEPACQTPQPSAR 152.2 2.2301e-11 15759000.0 16272.0 13279.0 16771.0 20665.0 21914.0 11383.0 14284.0 15939.0 18120.0 18754.0 True False 15367.66738197705 14297.456601285281 15691.97211888416 17850.391350886628 19160.967406354353 12950.904925414168 14948.234303209047 15985.379851156498 21744.506315101706 18212.52329125618 0.8437967181271941 0.7850343619409113 0.8616034070588047 0.9801163224568991 1.0520764805584912 0.7110988806055165 0.8207667912982537 0.8777136257023247 1.1939315583767147 1.0 14.152643196844497 -8.240706164158079 21.284418430177414 1.0969655138801062 0.8669104020359079 0.46010720349149403 0.09984791109628276 96.32356964548893 98885.98691237885 0.0710951932492767 0.026741166051306144 5.7450503052278425e-09 8.240706164158079 -0.23005511184419836 AELGSWSS(ph)QEHLEWEPACQTPQPSAR ddPTM_A459_Selumetinib_30min_R1 3 AELGSWSSQEHLEWEPACQTPQPSAR 26 0 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6;H3BTL6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 AELGS(0.02)WS(0.205)S(0.775)QEHLEWEPACQTPQPSAR;AELGS(0.002)WS(0.046)S(0.952)QEHLEWEPACQTPQPSAR;AELGS(0.007)WS(0.177)S(0.816)QEHLEWEPACQTPQPSAR 170.83 1.8169e-17 117110000.0 6598.2 7696.2 6725.6 7603.2 8397.9 6334.5 7196.299999999999 6433.5 2553.37 5701.4800000000005 True False 6751.925222137756 6795.125326133684 5812.300461076362 6275.443849740298 7638.311427769666 6270.78068126582 6653.477297225628 6262.862681046829 4332.882399233775 6433.320495118155 1.0495241496613406 1.05623920513366 0.9034681958542177 0.9754595398289795 1.1873046638304283 0.9747346935419001 1.0342213328676126 0.9735039138496712 0.6735063801844986 1.0 12.65134784730903 -8.020462754755492 22.170827487524207 0.8323369558358311 1.0231352968984573 0.3548432590987517 0.10056867384975594 183.17903707290796 198465.0779537969 0.0633350481414662 0.024728498706175647 9.539755526057896e-09 8.020462754755492 0.19079834106262616 AELGSWSS(ph)QEHLEWEPACQTPQPSAR ddPTM_A459_Selumetinib_30min_R2 3 AELGSWSSQEHLEWEPACQTPQPSAR 26 0 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6;H3BTL6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 AELGS(0.031)WS(0.447)S(0.522)QEHLEWEPACQTPQPSAR;AELGS(0.101)WS(0.224)S(0.675)QEHLEWEPACQTPQPSAR;AELGS(0.062)WS(0.17)S(0.768)QEHLEWEPACQTPQPSAR 112.85 8.717799999999998e-09 67215000.0 89827.0 72837.0 89718.0 104491.0 127263.0 97202.0 95831.0 98101.0 94504.0 101815.0 True False 84834.77494597183 78423.36369213175 83945.64155757232 90259.14554297093 111275.08419434488 110590.69318809689 100287.33138552403 98386.45766850525 113407.44066238264 98875.33640286078 0.8579973331298552 0.7931539506738176 0.8490048642215644 0.9128580374707018 1.1254078948562276 1.118486138317676 1.0142805580646541 0.9950556048440268 1.1469740057349773 1.0 16.593323077614407 -6.053135360812138 3.467997498862476 1.065877940538589 0.8322702807809212 0.8013401502864668 0.05300992010886949 0.10510493930926873 2.5332171178978293 0.016535595783452345 0.02312408037934959 8.848397801725252e-07 6.053135360812138 -0.23360765975766773 AELPGS(ph)SSPLLAQPR ddPTM_A459_Selumetinib_30min_R1 1 AELPGSSSPLLAQPR 15 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 AELPGS(0.454)S(0.454)S(0.092)PLLAQPR 113.52 0.0027419 3935600.0 2063.6 1821.9 1967.9 1873.3 2054.0 1750.1 1869.2 1944.2 1141.6 1720.4 True False 2111.6778649333887 1608.591101021668 1700.66998890094 1546.1633211961419 1868.216062663153 1732.4955829636601 1728.2047390984465 1892.633500348371 1937.2118208349264 1941.2300981151 1.0878039996308477 0.8286452505468473 0.8760785187455421 0.7964863736130194 0.9623877480970224 0.8924730688267623 0.8902626951727683 0.9749660806238707 0.9979300355562819 1.0 10.922755418548157 -7.8466835761340015 4.148009452012989 0.9952149756284931 0.8982963789297801 0.2172151472750934 0.0747999967324821 0.3233480146695612 10.292314953480458 0.04294476630276477 0.01968587958711752 1.42336546335735e-08 7.8466835761340015 -0.09691859669871306 AELPGSS(ph)SPLLAQPR ddPTM_A459_Selumetinib_30min_R1 1 AELPGSSSPLLAQPR 15 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 AELPGS(0.244)S(0.378)S(0.378)PLLAQPR 148.18 0.00030965 4085200.0 1550.7 1906.1 2084.3 1699.0 1869.8 1990.9 1730.6 2043.2 1084.7 1528.2 True False 1586.828292863057 1682.9329258781515 1801.263508240374 1402.3015441799198 1700.6769201400025 1970.8733535925676 1600.059448685947 1989.0076987510506 1840.6566766464994 1724.3593559285603 0.9202422264288157 0.9759757559188695 1.044598680691126 0.8132304553332425 0.9862659510576293 1.1429597588324394 0.927915311379119 1.1534763284187814 1.0674437844513642 1.0 10.751844747598858 -6.532173381692753 24.728655802880024 1.0603335197589694 0.9426382618425719 0.3292937430901135 0.080921707768903 210.36165601061114 559668.8016842268 0.025974496952039787 0.026009961932322252 2.9364770996168117e-07 6.532173381692753 -0.11769525791639746 AELPGSS(ph)SPLLAQPR ddPTM_A459_Selumetinib_30min_R2 4 AELPGSSSPLLAQPR 15 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 AELPGS(0.094)S(0.453)S(0.453)PLLAQPR;AELPGS(0.065)S(0.468)S(0.468)PLLAQPR;AELPGS(0.056)S(0.472)S(0.472)PLLAQPR;AELPGS(0.2)S(0.685)S(0.115)PLLAQPR 245.39 6.305100000000001e-21 34790700.0 158370.0 133819.0 155390.0 168876.0 172728.0 156150.0 158485.0 142119.0 131673.0 135061.0 True False 149568.42940534084 144082.48700409653 145392.3765758398 145874.79747265123 151028.36443208784 177658.24511143126 165854.86653206986 142532.54276093296 158011.2792510143 131161.43799937866 1.1403384385435709 1.0985125598026693 1.108499409533224 1.1121774791257037 1.15146926364747 1.354500589664722 1.2645093638944058 1.0866954871416412 1.2047083476758071 1.0 17.00098409847469 -6.52788759658857 24.999382943471183 1.1993564370628251 1.1155776312032362 0.09461072345812016 0.09041278119956687 265.4940233995956 1325077.6081553297 0.02993343627040637 0.030033908432514845 2.9655988418099496e-07 6.52788759658857 -0.08377880585958897 AENGERS(ph)DLEEDNER ddPTM_A459_Selumetinib_30min_R1 1 AENGERSDLEEDNER 15 1 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 AENGERS(1)DLEEDNER 121.95 0.00088806 9287600.0 2336.0 2993.0 2094.3 2068.2 2269.1 1858.4 2705.6 2546.3 1464.1 2702.5 True False 2390.424254935256 2642.57816859205 1809.905563166442 1707.0276949222553 2063.860305642142 1839.7061832921943 2501.514413708942 2478.763852451937 2484.4707663668655 3049.392199579201 0.7839018724010383 0.8665917650595129 0.5935299380041041 0.5597927662954655 0.6768103840256898 0.6033025806080514 0.8203321350576475 0.8128714478885308 0.8147429401536832 1.0 11.574306000112882 -8.321931492841015 0.8664015159940434 0.9873163025939273 0.6845874958198896 0.501016088006866 0.09418325463059632 0.5245153248225269 0.8565101893740991 0.09880646484068235 0.036180694324925204 4.765061466546531e-09 8.321931492841015 -0.3027288067740377 AENGERS(ph)DLEEDNER ddPTM_A459_Selumetinib_30min_R2 2 AENGERSDLEEDNER 15 1 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 AENGERS(1)DLEEDNER;AENGERS(1)DLEEDNER 120.21 0.0010001 88222000.0 42011.0 26603.8 35944.0 39539.0 47401.0 43330.0 53238.0 53922.0 53395.0 30922.0 True False 39676.196803357765 28644.22591530036 33631.40217286817 34153.71999142059 41446.06260968339 49298.314189422446 55713.67248909572 54078.90409273237 64075.49198095222 30029.201514995424 1.3212538063506285 0.9538790400735944 1.1199565914556184 1.137350254696767 1.3801919637785516 1.6416791556979886 1.8553164812349228 1.8008771916804867 2.1337727527971526 1.0 14.87407849328328 -6.619543128206316 1.9420788141074288 1.764709095360902 1.1146899367701666 0.45268318924515305 0.28326272963019034 0.2611365534353484 2.0132154851512802 0.10320822851970414 0.10457248053722584 2.401357785931838e-07 6.619543128206316 -0.6500191585907353 AENNS(ph)EVGASGYGVPGPTWDR ddPTM_A459_Selumetinib_30min_R1 1 AENNSEVGASGYGVPGPTWDR 21 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 AENNS(0.854)EVGAS(0.146)GYGVPGPTWDR 230.62 5.9397e-25 8427500.0 2013.5 2870.6 2634.0 2521.1 2689.8 2317.7 2197.5 2481.9 1412.5 1684.4 True False 2060.410632411017 2534.508817494265 2276.317267526336 2080.83721190818 2446.50806492276 2294.386042303228 2031.7408057825999 2416.0719496526203 2396.909335081758 1900.6091474454045 1.0840790886334524 1.3335244760348968 1.197677739574135 1.094826474293791 1.2872231348623646 1.2071845731075725 1.0689945423620888 1.2712092609361825 1.2611269067621962 1.0 10.8922461627726 -10.98055667622726 3.4676990609089455 0.9973372957680895 1.202299376242534 0.3227452474389271 0.08716833524188862 62546005.14188448 74908122.39047594 1571832.332513191 0.021219483266647472 1.0457872044072625e-11 10.98055667622726 0.20496208047444453 AENNS(ph)EVGASGYGVPGPTWDR ddPTM_A459_Selumetinib_30min_R2 4 AENNSEVGASGYGVPGPTWDR 21 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 AENNS(0.972)EVGAS(0.005)GY(0.01)GVPGPT(0.013)WDR;AENNS(0.994)EVGAS(0.001)GY(0.005)GVPGPTWDR;AENNS(0.939)EVGAS(0.061)GYGVPGPTWDR;AENNS(0.9)EVGAS(0.1)GYGVPGPTWDR 235.25 9.8064e-26 15035700.0 38502.5 33248.0 37117.7 35954.2 39847.0 33610.4 27940.9 34767.4 25276.9 33897.5 True False 36362.685187719486 35798.0146908301 34729.58759269612 31057.175935545514 34841.06362330024 38239.92751516651 29240.207213843012 34868.56737794708 30332.986295595703 32918.791098717964 1.104617878544624 1.0874644388816657 1.055007988858032 0.943448252471065 1.058394383889059 1.161644344729773 0.8882527649984626 1.059229887069123 0.9214489743755212 1.0 15.006623735117353 -7.267331021993829 24.99979719416107 0.9721687375171335 1.0625475872430354 0.3532586525200694 0.06666205074724844 643.6443274279968 2731141.0861350307 0.027742561744300294 0.01929286842936883 5.4034231362731044e-08 7.267331021993829 0.09037884972590193 AENNSEVGAS(ph)GYGVPGPTWDR ddPTM_A459_Selumetinib_30min_R1 1 AENNSEVGASGYGVPGPTWDR 21 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 AENNS(0.081)EVGAS(0.918)GYGVPGPT(0.001)WDR 202.21 7.48e-17 7178800.0 501.45 605.24 538.43 785.89 594.34 536.96 438.41 603.28 246.75 492.9 True False 513.1328093481524 534.3782194315579 465.3141633842845 648.6490644823763 540.5820519392494 531.5586699206717 405.34038073408396 587.2790546703866 418.71672809304306 556.1685162525763 0.9226211019739207 0.960820693397318 0.836642402053856 1.1662815235442079 0.9719752847242281 0.9557510977109529 0.7288085695055853 1.055937251945563 0.7528594587020611 1.0 9.119378268274737 -7.0250631166774316 24.763612150472703 0.8823794831885788 0.973324729456562 0.10830550230356373 0.11956578110440468 1505.0422610688563 1487052.4385262285 0.0437634730150756 0.0340662084023527 9.439236844526495e-08 7.0250631166774316 0.09094524626798317 AENSHNAGQVDTR ddPTM_A459_Selumetinib_30min_R2 1 AENSHNAGQVDTR 13 0 Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;E9PDP5;D6RHC4;Q8IWZ3-5;Q8IWZ3-3;Q8IWZ3-2 Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 0 108.36 0.008856999999999999 727470.0 4213.2 2991.8 5615.0 4564.6 4286.9 3237.1 3685.2 3964.7 3567.4 5808.0 False True 3979.047210775918 3221.2614398467736 5253.737013149754 3942.893605625798 3748.3412966277465 3682.981141531951 3856.5691020852682 3976.2366206085794 4280.979681484206 5640.30794900373 0.7054663055194978 0.5711144620065928 0.9314627961187372 0.6990564418246431 0.6645632349364596 0.652975187672597 0.6837515144481552 0.7049680011374057 0.7589975086804209 1.0 12.461558217564884 -8.814758566466818 2.0393943875829015 0.9999336137044901 0.7012897090249243 0.5182970297133349 0.08601409068964758 1.113304317535276 6.623914137236061 0.08320049070288502 0.022955886437382333 1.5319388623783522e-09 8.814758566466818 -0.2986439046795658 AENYDIPSADR ddPTM_A459_Selumetinib_30min_R2 2 AENYDIPSADR 11 0 P22314;P22314-2;Q5JRR6 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 ; 132.03 0.028948 23798800.0 74210.0 73126.0 103588.0 135933.0 136475.0 94454.0 81402.0 99325.0 95982.0 110197.0 False True 70085.70528616745 78734.52906285027 96923.26085808649 117418.69090249586 119329.79039801982 107464.18113195716 85187.35429500294 99614.01930586119 115181.08196115284 107015.32628380897 0.6549127841772618 0.7357313367810805 0.9056951394143498 1.0972137821744965 1.1150719671830218 1.004194304346256 0.7960294777692181 0.9308388131404728 1.0763045440396823 1.0 16.707457902560783 -5.2869974125419015 2.6920967748626468 0.9961843640151677 0.6728173266273166 0.6566900275082841 0.08807416968750842 0.19083880181276386 2.686416848931637 0.027025204884358795 0.08160954079782856 5.164194460086012e-06 5.2869974125419015 -0.3233670373878511 AEPEAGEEQAGDDRDS(ph)GGPVLQFDYEAVANR ddPTM_A459_Selumetinib_30min_R1 1 AEPEAGEEQAGDDRDSGGPVLQFDYEAVANR 31 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 AEPEAGEEQAGDDRDS(1)GGPVLQFDYEAVANR 120.18 2.4515e-16 4999400.0 153.01 210.26 247.99 353.1 354.86 221.9 193.07 142.26 61.615 173.4 True False 156.57483529436786 185.64266145277787 214.31432011156272 291.4377135079048 322.76297565562163 219.66788746907966 178.50657445845118 138.48680267439528 104.55615481845129 195.65757905903172 0.8002492724655852 0.948814057424107 1.0953540422111738 1.4895293855188472 1.6496318579013034 1.1227159639075561 0.9123417314930289 0.7078018819430067 0.5343833615916597 1.0 7.612187185825341 -7.41027336132086 2.7242003438325453 0.7230083174954879 1.2062595809398007 0.38100751615151107 0.252670552975728 0.3137328256736607 4.512492412960347 0.1399281814644813 0.08451167721718904 3.888003423641656e-08 7.41027336132086 0.4832512634443128 AEPSEVDMNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 AEPSEVDMNSPK 12 0 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 AEPSEVDMNS(1)PK;AEPSEVDMNS(1)PK;AEPS(0.004)EVDMNS(0.996)PK;AEPS(0.001)EVDMNS(0.999)PK 180.95 0.00010345 482696000.0 17971.5 20803.3 21850.2 22906.0 13661.1 17192.4 15654.4 13878.3 10418.900000000001 14257.9 True False 18390.20098354836 18367.639964808215 18883.062854557305 18905.897098873007 12425.455917063106 17019.460065450232 14473.576004570246 13510.202400928294 17680.1123336519 16088.040348706858 1.1430976417849763 1.1416952945598864 1.1737329373415644 1.1751522677149828 0.772341170692169 1.0578951629008215 0.8996481666416022 0.8397668148572385 1.0989599696692092 1.0 13.973700984580233 -6.231837919375747 24.997420743981806 0.9401571905935756 1.1583188029226763 0.5669762849918063 0.09141779980117141 492.5683120979984 415957.06729836913 0.025639248198299724 0.03309530019333852 5.863569546973822e-07 6.231837919375747 0.2181616123291007 AEPSEVDMNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 AEPSEVDMNSPK 12 0 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 AEPSEVDMNS(1)PK;AEPS(0.007)EVDMNS(0.993)PK;AEPSEVDMNS(1)PK;AEPSEVDMNS(1)PK;AEPSEVDMNS(1)PK;AEPSEVDMNS(1)PK 196.37 0.00010945 486656000.0 1788097.0 1657797.0 1535949.0 1366968.0 1421056.0 1160477.0 1447195.0 1235736.0 1062117.0 1404061.0 True False 1688721.7270594295 1784944.6992424806 1437127.713554825 1180784.6002486737 1242530.2408781718 1320322.172988653 1514492.435062491 1239331.7871728928 1274570.078028526 1363522.1107414155 1.2384997014395216 1.3090691270652857 1.0539819649667332 0.8659812634843316 0.9112651940807514 0.9683173911061314 1.110720847965557 0.9089194648255509 0.9347630434357079 1.0 20.378906664368955 -5.40027832131403 3.8879866100308402 0.9581812946961535 1.2724301117468977 0.784998109780825 0.06522585250112174 0.10257680554141932 2.668257112797079 0.01849566194430031 0.04146597408125385 3.978521219196273e-06 5.40027832131403 0.31424881705074414 AEPYVAS(ph)EYK ddPTM_A459_Selumetinib_30min_R2 2 AEPYVASEYK 10 0 Q6ZSL5;A0A088AWN3;A0A0A0MSY4;Q9BZ29-3;Q9BZ29-5;Q9BZ29;Q9BZ29-4;A0A0A0MT38;Q9BZ29-6 Q6ZSL5 DOCK9 Dedicator of cytokinesis protein 9 1 AEPYVAS(1)EYK;AEPYVAS(1)EYK 126.1 0.0035135 10561200.0 65353.0 38577.0 53577.0 47314.0 35408.0 37659.0 35061.0 35269.0 23874.0 37315.0 True False 61720.94188878729 41535.7318553944 50129.91415022698 40869.75157879748 30959.730488463734 42846.185415634915 36691.405972053515 35371.62695090275 28649.46709529458 36237.61899398662 1.7032284019275505 1.1462047730643385 1.383366665413246 1.127826626401131 0.8543533308190387 1.1823675673267864 1.0125225384742358 0.9761024022238443 0.7906001522906005 1.0 15.145200545242194 -1.5228787458637034 0.4160450639044065 0.942366128691586 13.268285157686028 0.7015108097317195 0.13819641159307014 43.84289095862986 0.5658841800616261 0.09394341615785086 448.4455480852549 0.029999999959702515 1.5228787458637034 12.325919028994443 AEQGS(ph)EEEGEGEEEEEEGGESK ddPTM_A459_Selumetinib_30min_R2 1 AEQGSEEEGEGEEEEEEGGESK 22 0 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 AEQGS(1)EEEGEGEEEEEEGGESK 96.61 0.00072103 0.0 12593.0 10274.0 10655.0 10609.0 12251.0 10483.0 10870.0 12433.0 10983.0 10511.0 True False 11893.131473773168 11061.982763883198 9969.46890028684 9164.035898454213 10711.91985467039 11926.938094800731 11375.476538496381 12469.177971606041 13179.90689066015 10207.520119142253 1.1651342671830618 1.083709131578253 0.9766788391228352 0.8977729939781176 1.049414522787198 1.1684462000162055 1.114421172402477 1.2215678074660348 1.2911957788791182 1.0 13.317344790684215 -6.725963470151931 4.660419249260054 1.1710258827431215 1.0245176458646317 0.2945448479583943 0.09550591761668323 0.24252610601833596 12.033173216462924 0.03423222974515037 0.033039074366447325 1.879474898584096e-07 6.725963470151931 -0.1465082368784898 AEQGS(ph)EEEGEGEEEEEEGGESKADDPYAHLSK ddPTM_A459_Selumetinib_30min_R1 2 AEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 32 1 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 AEQGS(1)EEEGEGEEEEEEGGESKADDPYAHLSK;AEQGS(1)EEEGEGEEEEEEGGESKADDPYAHLSK 122.08 2.4848e-17 32647000.0 2867.21 3578.8999999999996 4377.3 5545.6 6063.6 4552.0 5146.3 2866.9 766.22 1692.31 True False 2934.01041438053 3159.88072421453 3782.8867027877864 4577.165063804687 5515.148450615528 4506.211012885312 4758.110447690098 2790.8604989963706 1300.2193775053763 1909.5344729953297 1.5365056016915941 1.6547911383123055 1.9810517988993848 2.397005724973828 2.8882162268400258 2.359847950698051 2.4917646237757842 1.4615397304760762 0.6809090885203183 1.0 10.89900524995924 -7.979644997561739 3.9589753479093757 0.8776245365201842 2.1973685056511827 0.6672739597357333 0.38446162448987653 0.14365973520103245 4.988187443858117 0.288409823243183 0.11735185001879449 1.0479848452785209e-08 7.979644997561739 1.3197439691309985 AEQGS(ph)EEEGEGEEEEEEGGESKADDPYAHLSK ddPTM_A459_Selumetinib_30min_R2 1 AEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 32 1 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 AEQGS(1)EEEGEGEEEEEEGGESKADDPYAHLSK 79.771 3.9396e-06 11976000.0 29050.0 33265.0 45752.0 55475.0 50822.0 23367.0 15315.0 15188.0 13274.0 59529.0 True False 27435.517296363912 35816.318536166495 42808.36613101113 47919.20930028726 44437.286005555376 26585.59214549352 16027.177846096776 15232.194565491245 15929.170906548554 57810.24309508316 0.474578825957183 0.6195496960159422 0.7404979436014867 0.8289051686129798 0.7686749549291348 0.4598768440009321 0.27723768294376727 0.2634860839529451 0.27554236159064605 1.0 15.819037518524782 -6.877711828053791 5.187570466213895 0.389983112955526 0.692647379437215 0.19030293194464398 0.22233665488888915 0.2688398497187731 11.1297257093441 0.07725767547833601 0.06814594330354808 1.325220580952108e-07 6.877711828053791 0.302664266481689 AEQLVLSGADS(ph)DEDTSR ddPTM_A459_Selumetinib_30min_R2 1 AEQLVLSGADSDEDTSR 17 0 H7C1N2;J3KR05;O75128-2 H7C1N2 COBL Protein cordon-bleu 1 AEQLVLSGADS(1)DEDTSR 152.04 0.00040491 0.0 8594.0 7493.0 7156.8 6856.8 9637.6 6397.2 6566.3 6834.8 8545.8 7175.5 True False 8116.379884507787 8067.6890062075945 6696.339279734665 5922.8920113602435 8426.838526762824 7278.356232000308 6871.6459608766145 6854.688136437947 10255.19878960243 6968.324670812028 1.164753404574356 1.1577659462396226 0.9609683239621973 0.849973600709113 1.2093062428706889 1.0444915493801399 0.9861259751084263 0.9836924167942309 1.4716878552685717 1.0 12.766596128756486 -8.207233125220943 24.999195672835864 1.2358483146358015 1.0426621022306268 0.21174502154195873 0.14752971053877798 400.095362497255 184518.92567832395 0.09676291035460181 0.03657289266507854 6.205358469662148e-09 8.207233125220943 -0.19318621240517464 AEQPS(ph)PPNS(ph)DSGQDAHPDPDANPDAAR ddPTM_A459_Selumetinib_30min_R2 1 AEQPSPPNSDSGQDAHPDPDANPDAAR 27 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 2 AEQPS(0.96)PPNS(0.851)DS(0.19)GQDAHPDPDANPDAAR 73.23899999999998 0.0010747 7334700.0 20120.0 16285.0 21934.0 21615.0 22166.0 17312.0 16583.0 17274.0 15454.0 20373.0 True False 19001.81094674154 17534.007135471857 20522.790319933534 18670.999712045224 19381.308913445766 19696.57085731091 17354.142358591125 17324.264480135364 18545.23182083784 19784.77855458901 0.9604257583329957 0.8862372195419344 1.0373019977609679 0.943705266173654 0.9796070681291673 0.9955416383845428 0.8771461510528705 0.8756360063538371 0.9373484656231513 1.0 14.272103297274308 -7.257799226120994 24.983551143620783 0.9121689899358211 0.9661503811863091 0.1534473997917627 0.04892821412275059 493.8634601374322 3389558.277449584 0.018817423561225063 0.014006268616015671 5.523327231003833e-08 7.257799226120994 0.053981391250488064 AEQPS(ph)PPNSDSGQDAHPDPDANPDAAR ddPTM_A459_Selumetinib_30min_R2 1 AEQPSPPNSDSGQDAHPDPDANPDAAR 27 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 1 AEQPS(0.755)PPNS(0.136)DS(0.109)GQDAHPDPDANPDAAR 52.697 0.011343 7270500.0 3636.7 4640.0 5271.5 5587.5 7507.8 4814.3 4899.7 3828.1 5087.8 5077.7 True False 3434.5867728635667 4995.873080048475 4932.337429175235 4826.472861024873 6564.603043416405 5477.426125135856 5127.545758571358 3839.2391372239285 6105.502165009622 4931.093607551005 0.6965162388327346 1.0131369383047752 1.0002522405217222 0.978783459643531 1.3312671723294807 1.110793377912812 1.0398394690215422 0.7785776224861934 1.238163914726794 1.0 12.267691924616878 -4.331577164715161 1.4862141825995285 1.0634440240857495 5.813877068355194e-14 0.36750578481288365 0.1419476065894944 4.410091677942384 3.661190957349589 0.040890963533744405 9.619654297122347 4.660396155078546e-05 4.331577164715161 -1.0634440240856913 AEQPSPPNS(ph)DSGQDAHPDPDANPDAAR ddPTM_A459_Selumetinib_30min_R2 1 AEQPSPPNSDSGQDAHPDPDANPDAAR 27 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 1 AEQPS(0.065)PPNS(0.896)DS(0.039)GQDAHPDPDANPDAAR 101.85 1.1928e-05 0.0 12482.0 10013.0 16256.0 22774.0 23611.0 14657.0 14619.0 16304.0 22103.0 13645.0 True False 11788.300409404965 10780.964903130474 15210.106658194549 19672.141912658713 20644.77509498187 16675.868707001267 15298.81246699895 16351.441940727502 26524.21760942014 13251.033396032351 0.8896136668808516 0.8135942745686937 1.147843055225322 1.4845741705359359 1.5579747237799102 1.258457978982559 1.1545373111488608 1.2339748495104903 2.0016716294264314 1.0 13.693817253730636 -5.47688796317665 3.3811934721789108 1.3854469006703192 0.8560981052828966 0.4033489874943609 0.25820620333615696 0.23622161699175256 5.404059175912264 0.07032759151686517 0.15365934188764482 3.3351243931095115e-06 5.47688796317665 -0.5293487953874225 AES(ph)DGEEKEEVK ddPTM_A459_Selumetinib_30min_R1 1 AESDGEEKEEVK 12 1 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 AES(1)DGEEKEEVK 131.53 0.011973 0.0 825.67 1106.9 520.22 510.42 610.47 785.06 902.84 935.64 464.84 1061.8 True False 844.9065045258528 977.3036334161507 449.5769813639144 421.2847287700499 555.2530962872323 777.1630091774477 834.7380519193462 910.8237878129568 788.7995294296664 1198.0923728078421 0.7052098182928375 0.8157164302162676 0.3752440058609909 0.3516295891131746 0.4634476513575865 0.6486670200195775 0.6967226157721538 0.760228350071502 0.6583795601511431 1.0 10.226523428727237 -8.553037448710342 0.6271026431747039 0.9913858740814607 0.5509107135234286 0.4394317625308115 0.1433682159161569 0.9240108399229745 0.8389281494722517 0.16705485749088164 0.0697799428069414 2.7987399771213673e-09 8.553037448710342 -0.44047516055803215 AES(ph)DGEEKEEVK ddPTM_A459_Selumetinib_30min_R2 1 AESDGEEKEEVK 12 1 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 AES(1)DGEEKEEVK 142.1 0.0044453 3607600.0 31419.0 18619.0 27560.0 29880.0 28580.0 28085.0 43138.0 43973.0 27734.0 23127.0 True False 29672.857760222265 20047.01743047899 25786.81960505916 25810.29245412497 24989.52489155822 31953.45381975374 45144.002476325346 44100.954149877965 33281.57495270585 22459.26341883769 1.3211857043955493 0.8925946081412701 1.1481596312473226 1.1492047612067549 1.1126600381114136 1.4227293755748376 2.0100393158246166 1.9635975288881613 1.4818640456743988 1.0 14.455022992977385 -6.9486642211032965 3.9285080398891457 1.6986045937302687 1.117051745862356 0.38592062759445767 0.28306043216450455 0.18911651668853122 6.099974954000631 0.10193112043329712 0.08701823221470259 1.1254748091834984e-07 6.9486642211032965 -0.5815528478679128 AES(ph)GPDLR ddPTM_A459_Selumetinib_30min_R1 1 AESGPDLR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 AES(1)GPDLR 86.882 0.03325 31285000.0 5785.4 6653.8 7178.7 7460.5 7378.1 6383.0 7207.2 6324.8 3268.1 6056.8 True False 5920.188563571241 5874.770002732302 6203.871969776499 6157.663725929542 6710.752157709352 6318.792815300295 6663.55510144999 6157.04575815419 5545.727007419958 6834.249278228049 0.8662529449183625 0.8596072170571284 0.9077620258219509 0.9010007500818102 0.9819296728154001 0.9245774565803665 0.975023712213448 0.9009103278934769 0.8114610371452279 1.0 12.738567155476467 -5.472304669575026 1.89611730072372 0.928492321772402 0.8606996612084294 0.2078484791085119 0.050320001585027356 0.6100262701809097 4.199237764214536 0.015069241272038757 0.043713932416599835 3.370507752724338e-06 5.472304669575026 -0.0677926605639726 AES(ph)GPDLR ddPTM_A459_Selumetinib_30min_R2 2 AESGPDLR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 AES(1)GPDLR;AES(1)GPDLR 125.57 0.005056399999999999 104406000.0 1207760.0 988950.0 1202720.0 1256780.0 1244130.0 966140.0 1000430.0 1139280.0 803730.0 948970.0 True False 1140637.53424635 1064799.2850245556 1125338.3046225223 1085604.3959335724 1087831.2667366823 1099217.0152542957 1046951.977314438 1142595.116182043 964498.4580925335 921570.7703798326 1.2377101910211705 1.1554178140716098 1.2211089379046878 1.1779935202221443 1.180409906325831 1.192764625988783 1.1360516315886717 1.2398343707354276 1.0465809996285016 1.0 19.813735433733527 -8.397458042762915 4.567575911755013 1.0025344656772572 1.1892651131938212 0.8170009929830845 0.032298171052683046 0.07875815673269221 2.3862081695290582 0.028529267884781603 0.00746404543235162 4.004441534150026e-09 8.397458042762915 0.18673064751656399 AES(ph)KESVGSR ddPTM_A459_Selumetinib_30min_R1 1 AESKESVGSR 10 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 AES(0.995)KES(0.005)VGSR 133.88 0.010427 4385500.0 1370.3 2077.5 1663.7 1243.9 1608.8 1523.8 1395.0 1695.8 1993.4 1821.5 True False 1402.2253238603505 1834.2653341964524 1437.7786780499491 1026.6762158948811 1463.2843240567101 1508.4719554997007 1289.7740268790571 1650.8218752652858 3382.6542078244056 2055.3072679124934 0.6822460786043654 0.8924530958621355 0.6995443944059287 0.49952444187950623 0.7119540454614939 0.7339398731518159 0.6275334335722158 0.8031995512485927 1.6458143561473677 1.0 11.005138377233651 -8.116450145084292 6.1493532305365814 1.3150012568101959 0.6967863250586844 0.6775492667994523 0.17141934674215134 0.12339866888285805 5.7003484531989335 0.11182993931930053 0.041355796741870385 7.648034791571934e-09 8.116450145084292 -0.6182149317515114 AES(ph)LDDQMLSR ddPTM_A459_Selumetinib_30min_R1 3 AESLDDQMLSR 11 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AES(1)LDDQMLSR;AES(1)LDDQMLSR;AES(1)LDDQMLSR 168.89 0.00045325 43962500.0 6647.4 7550.999999999999 8637.2 9199.5 8097.0 6338.4 7046.5 7358.7 2895.74 5869.700000000001 True False 6802.271486411226 6666.925409635339 7464.315680743534 7592.980021002461 7364.627779641455 6274.641450806735 6514.976831830301 7163.523371573687 4913.8592835183335 6623.133170719719 1.0270473673220797 1.0066120124398559 1.1270067335717495 1.1464332401725439 1.1119552619294775 0.9473826494303882 0.9836699133021262 1.081591323460471 0.7419236722042775 1.0 12.693298151319206 -6.765795736887178 24.989253301701066 0.9580602252053637 1.0854008854238777 0.3534541519666997 0.08959783045767186 134.9211872509706 773938.6010635071 0.031022121047752066 0.028307024214134918 1.7147636281360022e-07 6.765795736887178 0.12734066021851398 AES(ph)LDDQMLSR ddPTM_A459_Selumetinib_30min_R2 2 AESLDDQMLSR 11 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AES(1)LDDQMLSR;AES(1)LDDQMLSR 201.48 1.8715e-05 38972000.0 73787.0 66720.0 86315.0 88054.0 78164.0 43238.0 47471.0 55169.0 56947.0 68846.0 True False 69686.21393276438 71837.2094613867 80761.58687266636 76060.89329837759 68344.33952497406 49193.64202451531 49678.495562002 55329.53265628035 68337.99123212452 66858.23709661006 1.0422981065454642 1.0744705900274043 1.2079526828678713 1.1376443143194115 1.0222276639782857 0.7357902954191056 0.7430422595530995 0.8275649352873193 1.0221327124341646 1.0 16.028817694338613 -6.570313627367523 5.313017822882918 0.8480493004240298 1.1154219868794646 0.5964711657563413 0.0968786256645878 0.1306088406946338 8.373400379889116 0.0336294433979609 0.03399314459575922 2.6895918037631364e-07 6.570313627367523 0.26737268645543477 AES(ph)LPLSSNLQSK ddPTM_A459_Selumetinib_30min_R1 2 AESLPLSSNLQSK 13 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 AES(0.992)LPLS(0.003)S(0.004)NLQS(0.002)K;AES(0.999)LPLS(0.001)SNLQSK 165.64 0.00035285 22524500.0 9785.8 9745.6 11169.9 10990.5 10738.3 9625.1 9506.8 8798.400000000001 5455.799999999999 7553.599999999999 True False 10013.790100147871 8604.580621393472 9653.088931868795 9071.215492236268 9767.022661000849 9528.28023289157 8789.694422031409 8565.037850769017 9258.094124133837 8523.17813829471 1.1748892182783122 1.0095507194356317 1.1325691866625884 1.064299647977463 1.145936703718245 1.1179257406437308 1.031269589748364 1.0049112797826236 1.086225580870725 1.0 13.0571757702075 -7.268556568757553 24.027846367795682 1.0310108759931316 1.1039940869673486 0.38068155578781315 0.04794029912822397 362.51326505406524 1223847.9237800846 0.018751805435504976 0.01296037498121713 5.3881965718299534e-08 7.268556568757553 0.072983210974217 AES(ph)LPLSSNLQSK ddPTM_A459_Selumetinib_30min_R2 2 AESLPLSSNLQSK 13 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 AES(0.993)LPLS(0.006)SNLQSK;AES(0.999)LPLS(0.001)SNLQSK 172.09 0.00018471 26163000.0 110933.0 85042.0 100998.0 119320.0 110578.0 92854.0 95633.0 85812.0 76963.0 98214.0 True False 104767.78795998407 91564.4479468712 94499.89863830779 103068.41016151926 96686.20306013746 105643.79565531123 100080.12399319443 86061.6987130586 92357.75052589252 95378.30662938218 1.098444621868652 0.9600133529594864 0.9907902748317007 1.0806273858689799 1.0137127243812103 1.107629180981566 1.0492965070357394 0.9023194241377578 0.9683307849527374 1.0 16.541373548535866 -7.744424059741426 24.996940232595016 0.9514938258834342 1.0405505951323208 0.388529909453709 0.049265571447295244 232.49883402949618 341561.3142561159 0.023518022434701222 0.013535152747738824 1.8012580729247092e-08 7.744424059741426 0.08905676924888661 AES(ph)MLQQADK ddPTM_A459_Selumetinib_30min_R1 1 AESMLQQADK 10 0 A0A0A0MSQ0;P13797-3;P13797-2;P13797;H7C4N2 A0A0A0MSQ0 PLS3 Plastin-3 1 AES(1)MLQQADK 93.766 0.024759 5853600.0 1030.5 1170.6 1175.9 1127.6 1138.0 1039.6 1162.6 1103.3 536.41 1041.3 True False 1054.508644996053 1033.5456078028235 1016.2192387563477 930.685827673501 1035.0681009302182 1029.1425678812766 1074.9041459853706 1074.0368999765244 910.2485921636846 1174.9609981209326 0.8974839562185347 0.8796424812872351 0.864896145813815 0.7920993370519609 0.8809382631300618 0.8758950888813692 0.9148424055814799 0.9141042993717987 0.77470536776915 1.0 10.198397153153309 -6.727755016357172 3.0092073261379393 0.8928350051036161 0.8588777256773403 0.08071843933469591 0.05763873377904541 0.7840690172309588 14.562479940939843 0.020584398476585535 0.019525103279297535 1.8717376817725097e-07 6.727755016357172 -0.0339572794262758 AES(ph)MLQQADK ddPTM_A459_Selumetinib_30min_R2 2 AESMLQQADK 10 0 A0A0A0MSQ0;P13797-3;P13797-2;P13797;H7C4N2 A0A0A0MSQ0 PLS3 Plastin-3 1 AES(1)MLQQADK;AES(1)MLQQADK 131.53 0.0025934 15918800.0 63980.0 53865.0 65450.0 75179.0 64466.0 49799.0 51076.0 55112.0 46905.0 57924.0 True False 60424.247732232754 57996.27229672653 61239.01825657197 64939.490508991395 56367.204746647745 56658.36021968722 53451.135205173974 55272.36679571723 56287.31063520116 56251.58361537396 1.0741786070484667 1.0310158144752344 1.0886630085883469 1.1544473299280231 1.0020554289113772 1.0072313804904525 0.9502156520721561 0.9825921910687488 1.0006351291382567 1.0 15.779606091734891 -6.431281245809653 7.76179794688913 0.986819910206274 1.0831214226777892 0.6909711842597894 0.031714715539928 0.1817067544880412 13.736721218532507 0.010514785643433673 0.011908462342838056 3.704407494715808e-07 6.431281245809653 0.0963015124715152 AES(ph)PAEKVPEESVLPLVQK ddPTM_A459_Selumetinib_30min_R1 4 AESPAEKVPEESVLPLVQK 19 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AES(1)PAEKVPEESVLPLVQK;AES(0.999)PAEKVPEES(0.001)VLPLVQK;AES(1)PAEKVPEESVLPLVQK;AES(0.924)PAEKVPEES(0.076)VLPLVQK 131.56 0.00014566 188706500.0 16938.899999999998 18502.5 12338.599999999999 12310.8 12714.3 12619.2 17291.3 17018.4 9238.9 16280.4 True False 17333.54341263818 16336.21869842112 10663.085891078374 10160.949882336767 11564.293809891986 12492.262305316863 15987.003319694499 16567.016748445996 15677.738517442014 18370.14792452515 0.9435712485198311 0.889280737724021 0.5804572687649713 0.553122921169913 0.6295155519380996 0.6800305776873473 0.8702707994175146 0.9018444933874552 0.853435616406299 1.0 14.16507562326162 -7.3391090575835225 4.451638848079671 0.9035772647984002 0.7036321720741374 0.3787383305042151 0.1216960378970748 0.28497926268101315 10.522280787478444 0.05951781154916651 0.03948769775325421 4.580268551487126e-08 7.3391090575835225 -0.19994509272426275 AES(ph)PAEKVPEESVLPLVQK ddPTM_A459_Selumetinib_30min_R2 3 AESPAEKVPEESVLPLVQK 19 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AES(1)PAEKVPEESVLPLVQK;AES(0.993)PAEKVPEES(0.007)VLPLVQK;AES(1)PAEKVPEESVLPLVQK 136.46 9.6175e-05 54199400.0 267140.0 189760.0 219142.0 256431.0 234634.0 226464.0 277724.0 289242.0 226023.0 203472.0 True False 252293.42824614947 204313.98182543038 205042.6423037687 221504.65543185122 205157.17926542592 257657.36036449063 290638.7162996657 290083.64633340953 271233.91561027785 197597.23467625494 1.2768064728208837 1.0339921110747334 1.0376797157091413 1.120990664645517 1.0382593643152813 1.3039522581712175 1.470864290058769 1.4680551922130143 1.3726604831017493 1.0 17.592203231345387 -6.874732922373058 4.932600031460091 1.3692105779165196 1.0960368127630995 0.36465725959782636 0.14181098908277126 0.18843372951780557 7.359973517914266 0.04858992019831988 0.04286867533099891 1.3343417586667085e-07 6.874732922373058 -0.27317376515342007 AES(ph)PDLR ddPTM_A459_Selumetinib_30min_R1 2 AESPDLR 7 0 Q6UN15;Q6UN15-5;A0A0B4J203;Q6UN15-4 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 AES(1)PDLR;AES(1)PDLR 143.37 0.0032839 221230000.0 16069.5 18837.6 18566.3 20258.6 19106.8 16136.3 18460.3 16520.3 9287.5 14382.7 True False 16443.888084196107 16632.085034637355 16045.0984373858 16720.815811020213 17378.593313579524 15973.98347258815 17067.82470852721 16082.127978502822 15760.20916783845 16228.859644361806 1.0132497565784917 1.0248461937013325 0.988676887285802 1.030313662046447 1.0708450066371211 0.9842948810108044 1.0516958728185732 0.9909585966559294 0.971122402510507 1.0 13.986274008934782 -7.929983083122082 9.528627626666276 0.9840597815102988 1.0226894707563101 0.3010221281989962 0.025228918393737174 0.3863661843211989 48.99857651509134 0.013525916209032762 0.0064840142618151865 1.1749433210877063e-08 7.929983083122082 0.03862968924601129 AES(ph)PDLR ddPTM_A459_Selumetinib_30min_R2 2 AESPDLR 7 0 Q6UN15;Q6UN15-5;A0A0B4J203;Q6UN15-4 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 AES(1)PDLR;AES(1)PDLR 131.11 0.004056499999999999 504720000.0 355420.0 342460.0 403280.0 410150.0 402240.0 266335.0 303920.0 322190.0 259668.0 358350.0 True False 335667.17925898964 368725.58081754367 377333.4038580646 354286.86245178606 351707.0151287747 303020.2287015882 318052.8822060551 323127.5195585742 311608.8557301235 348003.5043948844 0.964551146812888 1.0595455969867063 1.0842804715836976 1.0180554447801533 1.0106421650561537 0.8707390151960853 0.9139358603847738 0.9285180047839889 0.8954187293945657 1.0 18.408742308521347 -6.630741136229791 5.555675794127583 0.9171749155714398 1.0346500083237906 0.6090960130866983 0.04242293138938008 0.1330743222483173 6.039136985399067 0.01397079340767508 0.013937142524933875 2.3402317318539306e-07 6.630741136229791 0.1174750927523508 AES(ph)PEEVACR ddPTM_A459_Selumetinib_30min_R1 2 AESPEEVACR 10 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AES(1)PEEVACR;AES(1)PEEVACR 147.28 0.00083069 172779000.0 4590.4 5896.1 6173.3 6124.9 6055.9 5585.8 5777.8 5097.5 2860.4 3987.0 True False 4697.347388636471 5205.781870977476 5334.999767509619 5055.301193612473 5508.144914255981 5529.61192350061 5341.975894266533 4962.297740986435 4853.88988464981 4498.770286668738 1.0441403070870676 1.1571566315363633 1.1858795687610213 1.1237073403354045 1.2243667854254163 1.229138535898705 1.1874302429035946 1.1030342570927159 1.0789370373129301 1.0 12.135314987488199 -8.335905418980126 1.6105723656153375 1.0059343053702459 1.1672224748573081 0.49984017243010925 0.0516917492832117 0.3061922273102987 1.5861169239279562 0.05109296076318187 0.015201964403534244 4.6141805163284e-09 8.335905418980126 0.16128816948706226 AES(ph)PEEVACR ddPTM_A459_Selumetinib_30min_R2 2 AESPEEVACR 10 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AES(1)PEEVACR;AES(1)PEEVACR 152.67 0.00062478 246180000.0 271760.0 249932.0 327360.0 363340.0 412520.0 291130.0 258921.0 329120.0 285480.0 333070.0 True False 256656.66714147487 269100.9807419554 306298.0140026186 313852.46520353935 360695.54962440894 331230.5148849887 270961.3395422281 330077.6847112511 342583.97697766137 323453.4036802129 0.7934888432808775 0.8319621240035122 0.9469617896043065 0.9703173985265412 1.1151391375711601 1.0240439924770888 0.8377136751670052 1.0204798618770679 1.059144758038664 1.0 18.303198368659622 -5.311633527910447 1.8874832636637497 1.0035288855886875 0.7905104256710856 0.5655347961527377 0.06676772552506591 0.3120657620009814 2.0059048009590135 0.020639530459654432 0.07867218629823812 4.879400564370923e-06 5.311633527910447 -0.21301845991760182 AES(ph)PESSAIEST(ph)QSTPQKGR ddPTM_A459_Selumetinib_30min_R2 1 AESPESSAIESTQSTPQKGR 20 1 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 2 AES(0.935)PES(0.029)S(0.036)AIES(0.266)T(0.638)QS(0.071)T(0.025)PQKGR 102.92 0.0020633 8038400.0 31392.0 45444.0 41324.0 45990.0 40059.0 17891.0 12385.0 12521.0 15851.0 35503.0 True False 29647.358312132725 48929.40867450924 38665.25883016926 39726.08266282486 35026.43028799618 20355.322851672212 12960.927040411925 12557.434037036857 19021.642913944645 34477.936142128 0.8598936487937608 1.4191513225388002 1.1214493428719141 1.152217537008668 1.015908555071485 0.5903869294194902 0.3759194572141223 0.36421652343897537 0.5517048014571391 1.0 15.073385796475511 -6.718448691771089 3.0261649969027093 0.5133483890224764 1.152094914930743 0.621271000735275 0.2092349512127252 0.14657839900969624 2.7454544858023806 0.07231425215261533 0.06897016696865628 1.9122792309171152e-07 6.718448691771089 0.6387465259082665 AES(ph)PESSAIESTQS(ph)TPQK ddPTM_A459_Selumetinib_30min_R2 1 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 2 AES(1)PESSAIES(0.017)T(0.054)QS(0.831)T(0.097)PQK 136.33 0.006411399999999999 25526000.0 81835.0 74348.0 93396.0 87621.0 87968.0 70115.0 81775.0 78172.0 67624.0 92034.0 True False 77286.93831146091 80050.25253350085 87387.00304187593 75686.86864534415 76916.67339610193 79772.7048094012 85577.69953408846 78399.46757792882 81150.68957243023 89376.73928695044 0.8647321319624969 0.8956497313746675 0.9777376500759742 0.8468296029724918 0.8605893883547869 0.8925443627260243 0.9574940886949915 0.8771797696291168 0.9079620740234225 1.0 16.447611791698385 -14.522878532776561 0.3115920071968186 1.9118254720006767 0.8939199306243238 0.3839951053028411 0.03922724125773919 336.8869734152436 3.0415216294165797 201.67719451435067 0.03791130352680402 3.000001467924443e-15 14.522878532776561 -1.017905541376353 AES(ph)PESSAIESTQST(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 2 AES(0.996)PES(0.002)SAIES(0.001)T(0.007)QS(0.15)T(0.843)PQK 257.88 3.0822999999999997e-40 10532000.0 2801.9 4213.3 2635.2 2999.6 2759.5 3183.3 3432.9 2877.7 1151.6 2567.5 True False 2867.178818451667 3720.0048772899704 2277.3543141174655 2475.7761694656215 2509.9037122292953 3151.2788922051436 3173.9535891563532 2801.3740479130256 1954.1810904638232 2897.0636345678413 0.989684446085482 1.284060464845429 0.7860905390354608 0.8545812180045318 0.8663612639643316 1.0877492833101763 1.095576069260148 0.9669701467675598 0.6745385455626455 1.0 11.500375658696425 -5.262983758750143 24.995780033533034 0.9238156870510857 1.1368724489232935 0.28220612311879845 0.14020434999940204 175.8513474982805 2846208.3986964053 0.037657198322724655 0.08579292247593973 5.457782711031266e-06 5.262983758750143 0.2130567618722078 AES(ph)PESSAIESTQST(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 2 AES(1)PESSAIESTQS(0.157)T(0.842)PQK;AES(0.98)PES(0.009)S(0.011)AIESTQS(0.292)T(0.708)PQK 236.66 1.3427e-22 28662000.0 93723.0 79553.0 105038.0 94791.0 97054.0 81151.0 81627.0 90176.0 74535.0 92083.0 True False 88514.25086289553 85654.45929678802 98279.96943672738 81880.30227640437 84861.20884623134 92328.81363456772 85422.81724083198 90438.39723055952 89444.08268190408 89424.32452963355 0.9898229741010071 0.9578429554522799 1.0990294861456764 0.9156379173909306 0.948972321486308 1.0324798551200873 0.9552525858053806 1.011340009625568 1.0002209482976188 1.0 16.44837969535392 AES(ph)PESSAIESTQSTPQK ddPTM_A459_Selumetinib_30min_R1 2 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 AES(0.996)PES(0.004)SAIESTQSTPQK;AES(1)PESSAIESTQSTPQK 292.2 6.7161e-81 99855000.0 7033.6 10577.0 10539.800000000001 12686.0 9656.199999999999 8625.2 9949.3 8182.299999999999 3609.7 6605.54 True False 7197.469194996835 9338.639922886106 9108.553050977256 10470.628245713044 8782.798414940578 8538.438319055005 9198.816290772615 7965.278824143853 6125.397257943087 7453.4254024082875 0.9656592514726517 1.2529326341508273 1.2220626838277844 1.404807545578958 1.178357324419287 1.1455723855901392 1.2341729867988445 1.0686735821586382 0.8218231118223711 1.0 12.863687888133386 -7.998091819083434 3.831850245055463 0.9136889208834136 1.2073047195965279 0.5225877722284555 0.11037448875042108 0.16908737339706506 5.4560565678278135 0.07518550619583371 0.02944275298098103 1.0044034156005168e-08 7.998091819083434 0.2936157987131143 AES(ph)PESSAIESTQSTPQK ddPTM_A459_Selumetinib_30min_R2 5 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 AES(0.951)PES(0.049)SAIESTQSTPQK;AES(0.949)PES(0.048)S(0.003)AIESTQSTPQK;AES(0.984)PES(0.016)SAIESTQSTPQK;AES(0.899)PES(0.1)S(0.001)AIESTQSTPQK;AES(1)PESSAIESTQSTPQK 237.34 3.2244999999999996e-65 253782000.0 452271.5 369364.8 475006.0 455232.0 478057.8 318779.5 345996.4 393918.5 296206.8 408979.9 True False 427136.0606162628 397693.892464977 444444.63110742887 393228.61628099816 417999.90527304256 362688.4825328175 362085.9181788603 395064.7376182819 355456.4367094951 397171.5876296052 1.0754446539479101 1.001315060924899 1.1190242327251003 0.9900723730714489 1.052441610357238 0.9131783184628353 0.9116611798438483 0.9946953657387796 0.8949694484213385 1.0 18.599402895258805 -6.7544594815365375 24.982858376111757 0.9406168398630025 1.0458503207601528 0.5603365227816084 0.04636173000911935 117.05293545318311 418962.186151865 0.014624989942912307 0.014323616983808329 1.760112869761335e-07 6.7544594815365375 0.10523348089715034 AES(ph)PMSR ddPTM_A459_Selumetinib_30min_R2 1 AESPMSR 7 0 Q6ZUT6 Q6ZUT6 C15orf52 Uncharacterized protein C15orf52 1 AES(0.999)PMS(0.001)R 96.034 0.023406 12092000.0 27127.0 21651.0 24144.0 26853.0 33855.0 24285.0 28325.0 33946.0 23253.0 28869.0 True False 25619.389937984975 23311.562081062402 22590.601325999578 23195.57507599124 29601.832232459885 27630.038312719233 29642.16862492271 34044.77723993718 27904.24974310483 28035.476959330015 0.9138203703525372 0.8315022467739567 0.8057862314513462 0.8273650956479237 1.0558704699549832 0.985538371713849 1.0573092324387225 1.2143462830799927 0.9953192443839799 1.0 14.77496599370919 -6.264208106099471 24.177185325631406 1.0591172475067014 0.8409078708392306 0.6994819509532663 0.06626491181534154 85.5585520627401 747117.8963862072 0.020878656380424555 0.024770286019510056 5.442417994740289e-07 6.264208106099471 -0.21820937666747087 AES(ph)PSPAPPPGLR ddPTM_A459_Selumetinib_30min_R1 2 AESPSPAPPPGLR 13 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 1 AES(0.68)PS(0.32)PAPPPGLR;AES(0.854)PS(0.146)PAPPPGLR 124.48 0.0022503 281190000.0 8715.7 9841.4 10462.0 11944.2 9826.9 9218.9 9301.0 9258.1 5012.1 7003.900000000001 True False 8918.7588522 8689.164312857269 9041.317863652439 9858.36969040248 8938.058630080106 9126.166236091474 8599.418081721935 9012.545113452961 8505.167630699663 7902.918788763281 1.1285398585749213 1.099487992362 1.1440479277742022 1.2474340119019756 1.130981966155167 1.1547842613627082 1.0881319056383278 1.1404071526418058 1.07620587507399 1.0 12.948169867618601 -8.651809341513681 0.7449118335859377 0.9992020190176384 1.1503904328877737 0.5641455866861134 0.0398210932015432 0.6775630674857905 0.8152268273891917 0.04178222063025473 0.015564634673266943 2.229413663537296e-09 8.651809341513681 0.15118841387013526 AES(ph)PSPAPPPGLR ddPTM_A459_Selumetinib_30min_R2 4 AESPSPAPPPGLR 13 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 1 AES(0.85)PS(0.15)PAPPPGLR;AES(0.953)PS(0.047)PAPPPGLR;AES(0.9)PS(0.1)PAPPPGLR;AES(0.972)PS(0.028)PAPPPGLR 166.62 0.00032724 290187000.0 434448.0 406104.0 463280.0 488340.0 474231.0 333024.0 356518.0 377757.0 323329.0 428020.0 True False 410303.11939313903 437250.8709698289 433473.06918112433 421827.2495665121 414653.8621010686 378895.03310912155 373096.79342701484 378856.2103289625 388003.83456708054 415661.950470484 0.9871077180115252 1.0519386498449248 1.0428500099431284 1.0148324836782623 0.9975747398378073 0.911546107793253 0.8975966960764871 0.9114527079039556 0.9334600728498303 1.0 18.665051164713397 -6.62587197620372 3.4851940127125807 0.9231411939359753 1.0260001149439142 0.6686516631585975 0.031090472332836024 0.12869482824790845 3.0584550261973873 0.010529038856314598 0.010530443314601021 2.36661723955177e-07 6.62587197620372 0.10285892100793892 AESCGS(ph)FDETESEESSK ddPTM_A459_Selumetinib_30min_R1 2 AESCGSFDETESEESSK 17 0 A8MXB7;Q9Y343-2;Q9Y343 A8MXB7 SNX24 Sorting nexin-24 1 AESCGS(0.963)FDET(0.035)ES(0.002)EESSK;AESCGS(0.942)FDET(0.054)ES(0.004)EESSK 290.37 9.294599999999999e-76 13863300.0 2847.08 3091.16 3246.15 3929.71 3301.28 2985.42 2749.67 3101.71 2004.3 2924.66 True False 2913.4114245466913 2729.245550158704 2805.340659825594 3243.4599182926872 3002.679806888322 2955.3893853444793 2542.260178127984 3019.4425750259993 3401.1507117199044 3300.068599600852 0.8828335947013564 0.8270269140734864 0.8500855588774439 0.9828462107378582 0.9098840573348992 0.8955539244553697 0.7703658579810959 0.9149635784514314 1.0306303063309892 1.0 11.688280299216604 -8.14458756009088 4.506210386141089 1.0137366318879633 0.8757867129036235 0.5230803131460099 0.05294351334010978 0.18972297963183907 5.955429343430602 0.041605391021755374 0.014588715703689827 7.168238388876829e-09 8.14458756009088 -0.13794991898433973 AESCGS(ph)FDETESEESSK ddPTM_A459_Selumetinib_30min_R2 1 AESCGSFDETESEESSK 17 0 A8MXB7;Q9Y343-2;Q9Y343 A8MXB7 SNX24 Sorting nexin-24 1 AESCGS(0.989)FDET(0.01)ESEESSK 287.88 1.2831999999999992e-75 13142000.0 42950.0 39832.0 36749.0 48197.0 42641.0 36876.0 41031.0 39220.0 27968.0 33101.0 True False 40563.0109424726 42886.98631993338 34384.6093492859 41632.48545553753 37284.05636462332 41955.334273001194 42939.022801384046 39334.12370677948 33562.38149121217 32145.288123273487 1.2618649049564625 1.3341608933622469 1.0696625028658904 1.295134929134302 1.1598606993859644 1.3051783549771683 1.3357796836885651 1.2236357489140441 1.0440840151285715 1.0 14.972319661445587 -8.28224706597245 3.5944019557240776 1.0058782930162267 1.2500982166673413 0.5789793880230554 0.07779757849315928 0.16360838076031664 4.318682892727559 0.07021365917256576 0.019946800738548893 5.2209908732622425e-09 8.28224706597245 0.24421992365111467 AESCGSFDET(ph)ESEESSK ddPTM_A459_Selumetinib_30min_R2 1 AESCGSFDETESEESSK 17 0 A8MXB7;Q9Y343-2;Q9Y343 A8MXB7 SNX24 Sorting nexin-24 1 AES(0.008)CGS(0.337)FDET(0.579)ES(0.076)EESSK 261.64 5.9787e-40 17700000.0 129340.0 107820.0 125660.0 114910.0 113830.0 99471.0 125500.0 129090.0 99790.0 115670.0 True False 122151.8005890431 116089.44730405722 117575.17240826311 99259.05976919344 99529.65774688862 113172.22734216574 131335.99867353222 129465.63052800002 119750.78836556301 112330.30655324766 1.0874340535262386 1.033465062690162 1.0466914585738198 0.8836356172689862 0.8860445662516626 1.0074950457694958 1.1691946964577662 1.1525440862803107 1.0660594815415896 1.0 16.77738769171522 -7.121260619234385 6.255973037921899 1.1089153608357218 0.9837942850125159 0.3223021519435948 0.0748762513422069 0.2761793862086637 13.031366403260218 0.031026606671461652 0.02400040085456715 7.563788573887069e-08 7.121260619234385 -0.12512107582320597 AESEASLLNVST(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AESEASLLNVSTPK 14 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 AESEASLLNVS(0.025)T(0.975)PK;AESEASLLNVS(0.037)T(0.963)PK 146.59 0.0011575 7330000.0 57655.0 62917.0 61667.0 53209.0 49715.0 41398.0 48086.0 51923.0 38312.0 66335.0 True False 54450.765911251634 67742.53158995908 57699.41235795297 45961.84240935526 43469.35724226092 47100.19872637228 50322.09428060136 52074.0873336846 45975.470526720506 64419.73619097142 0.8452497500119077 1.0515803943862372 0.895679115898641 0.7134745518532087 0.6747832234735736 0.7311454767021148 0.7811595833212078 0.8083561096759491 0.71368610374974 1.0 15.975215132217452 -5.61283804366898 5.053167872037131 0.7616693744565602 0.9542406852048414 0.35370784401219113 0.09702155570777043 0.182620929063462 7.774065966556715 0.025199314093381456 0.04480004414132581 2.4387200920046202e-06 5.61283804366898 0.19257131074828115 AESGDS(ph)LGSEDRDLLYSIDAYR ddPTM_A459_Selumetinib_30min_R1 4 AESGDSLGSEDRDLLYSIDAYR 22 1 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 AES(0.1)GDS(0.873)LGS(0.027)EDRDLLYSIDAYR;AES(0.093)GDS(0.714)LGS(0.193)EDRDLLYSIDAYR;AES(0.076)GDS(0.715)LGS(0.208)EDRDLLYSIDAYR;AES(0.014)GDS(0.785)LGS(0.201)EDRDLLYSIDAYR 88.28200000000002 0.00027561 84196000.0 4681.38 5625.7 6256.8 6494.5 5377.6 5264.46 5865.9 5179.7 3037.6299999999997 4041.66 True False 4790.447045620206 4967.040428683023 5407.160926142288 5360.357491863739 4891.197029492396 5211.504312147232 5423.430440336819 5042.3175299632 5154.636250282761 4560.446430102225 1.050433793937324 1.089156622013359 1.1856648266825673 1.1754019204088277 1.0725259257968647 1.1427618747470765 1.189232353336787 1.105663142248592 1.1302920293632779 1.0 12.154959343913804 -9.502781645009685 1.6131524601247604 0.9999303725197929 1.129253067266429 0.410489670888172 0.0454895211766944 32.35440439231912 51.31885948881773 0.052375941359542905 0.012977178834415059 3.1420880788162945e-10 9.502781645009685 0.12932269474663605 AESMLQQADK ddPTM_A459_Selumetinib_30min_R1 1 AESMLQQADK 10 0 A0A0A0MSQ0;P13797-3;P13797-2;P13797;H7C4N2 A0A0A0MSQ0 PLS3 Plastin-3 0 183.43 0.024154 10955000.0 2052.1 1906.8 2413.6 2365.3 2089.4 2098.2 2037.9 2219.0 1347.1 1605.9 False True 2099.909937308491 1683.5509695527287 2085.8463769557943 1952.2447571799685 1900.4141389135318 2077.094013013173 1884.1795622772975 2160.144911672171 2285.9303117087684 1812.032907790653 1.1588696476096763 0.9290951407750216 1.151108441788175 1.0773782025627066 1.0487746280671242 1.1462783065820252 1.039815311397744 1.1921113034894926 1.261528034000178 1.0 10.823393440639657 -7.767236873094636 24.998170692928735 1.170114768730197 1.0771766815360369 0.11192633289634724 0.08878327048178687 236.48409495227614 1019671.0193590989 0.0440498222805613 0.022052426670972906 1.709082892060681e-08 7.767236873094636 -0.09293808719416008 AESPES(ph)SAIESTQSTPQK ddPTM_A459_Selumetinib_30min_R1 1 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 AES(0.033)PES(0.904)S(0.063)AIESTQSTPQK 334.43 1.4515999999999992e-144 108750000.0 2713.9 3969.3 4225.7 4695.4 3791.7 3568.7 3758.9 2988.2 1539.1 1954.7 True False 2777.1285896698605 3504.5725107224916 3651.873150108596 3875.4365335740995 3448.7414044790053 3532.8021181203476 3475.36314669225 2908.9432289584424 2611.7402885835972 2205.6047853903647 1.2591233969318503 1.588939475438355 1.6557241688529705 1.7570856570698794 1.5636261887546734 1.601738507968954 1.575696230672239 1.3188868868198413 1.1841379316382612 1.0 11.106958587269482 -8.14321601861656 1.4406369048056566 1.0178220400977416 1.5893083128166698 0.7192184756935602 0.12250254070732751 0.21475706926358162 0.8145609108948014 0.11649301740050037 0.037068037136284725 7.190912121693537e-09 8.14321601861656 0.5714862727189283 AESPESSAIESTQS(ph)TPQK ddPTM_A459_Selumetinib_30min_R2 1 AESPESSAIESTQSTPQK 18 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 AESPESSAIESTQS(0.5)T(0.5)PQK 211.45 9.353e-12 2682300.0 20430.0 14853.0 16180.0 15140.0 18070.0 16069.0 15888.0 13124.0 14504.0 16729.0 True False 19294.58238776986 15992.177340077584 15138.996415452 13077.905882043244 15799.885052150352 18282.358890141462 16626.823481474737 13162.188667204848 17405.205275620036 16245.990302838045 1.1876519700002068 0.9843768857404697 0.9318604857721317 0.8049928405877872 0.9725405935635846 1.1253459191679858 1.0234416721626483 0.8101807536414396 1.0713539126377223 1.0 13.987796067904315 -4.764534141688679 4.444812339529243 0.9623939147499071 1.2065338690951932 0.3168651815495881 0.09620600320890811 0.25899414672936694 11.096893881533969 0.025119008770362983 0.20300158186573997 1.7197521390826328e-05 4.764534141688679 0.24413995434528613 AESPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 AESPSPPR 8 0 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 AESPS(1)PPR 150.81 0.0012315 3522700.0 828.97 915.13 820.35 1075.1 1165.8 866.12 793.19 1140.4 575.48 712.25 True False 848.2833881051707 807.9861541676049 708.9509758599962 887.3539671264464 1060.3535958387076 857.4076191740388 733.3590396990677 1110.15288745874 976.5475286037874 803.6742254025107 1.055506524027591 1.0053652694447612 0.8821372559321864 1.1041214699675428 1.3193823595719298 1.0668596703404496 0.9125078502197498 1.3813468845572758 1.21510370463193 1.0 9.65046700381472 -5.967685389633414 10.878673219784178 1.157707465846645 0.9848715283012995 0.22954836373532828 0.13735349396818744 0.8128219771218079 267.9898789349107 0.039914731912423604 0.05911298488234948 1.0772453060034485e-06 5.967685389633414 -0.17283593754534554 AESPS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 AESPSPPR 8 0 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 AES(0.037)PS(0.963)PPR 106.18 0.013838 8437200.0 34466.0 25978.0 34072.0 37779.0 39888.0 33251.0 29759.0 31180.0 26995.0 29546.0 True False 32550.517698329706 27970.429067564495 31879.84461478867 32633.435027589934 34876.912836755604 37831.02342747487 31142.852466339802 31270.728637873126 32394.75430332066 28692.930210272763 1.1344438319748826 0.9748195413499596 1.1110696739984722 1.1373336493846966 1.2155228685660284 1.3184789127577654 1.085384177848448 1.0898408914220077 1.12901519872385 1.0 14.808407687633872 -4.380798687516072 21.720623154403068 1.1250379175222152 12.604340883737482 0.0 0.09326325733996021 17437.519042425793 2780014.6507660737 0.024000448487192134 428638.2589525064 4.161034460242452e-05 4.380798687516072 11.479302966215267 AESSAGDGPVPYSQGSSSLIMPRPNS(ph)VAATSSTK ddPTM_A459_Selumetinib_30min_R2 1 AESSAGDGPVPYSQGSSSLIMPRPNSVAATSSTK 34 1 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 AESSAGDGPVPY(0.036)S(0.036)QGS(0.068)S(0.068)S(0.068)LIMPRPNS(0.555)VAAT(0.071)S(0.071)S(0.022)T(0.007)K 92.788 4.3612e-08 0.0 11413.0 9494.6 11851.0 13364.0 13294.0 8532.6 8797.7 9018.4 7227.7 11851.0 True False 10778.711149858911 10222.805290049195 11088.519562393185 11543.800145814123 11623.888870132096 9707.888198769118 9206.810482311834 9044.64205092351 8673.441958811287 11508.830837404132 0.9365600469882394 0.8882574984788806 0.9634792377306547 1.0030384761844218 1.009997369355193 0.8435164558347767 0.7999779136894909 0.7858871312564683 0.7536336298055816 1.0 13.490453659522379 -6.874952964190215 5.829024661333513 0.8179130498407363 0.958379994378176 0.43083040733602507 0.06989638434583759 0.1843901603914246 8.729419865010716 0.02458706426930291 0.021698836928918473 1.3336658656289843e-07 6.874952964190215 0.1404669445374397 AESSSGGGTVPSSAGILEQGPSPGDGS(ph)PPKPK ddPTM_A459_Selumetinib_30min_R1 5 AESSSGGGTVPSSAGILEQGPSPGDGSPPKPK 32 1 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 AESSSGGGTVPSSAGILEQGPS(0.002)PGDGS(0.998)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.378)PGDGS(0.622)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.248)PGDGS(0.752)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.005)PGDGS(0.995)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.231)PGDGS(0.769)PPKPK 117.97 8.0015e-17 137089600.0 19703.050000000003 27254.65 18850.760000000002 19064.1 16158.19 20320.55 21367.559999999998 21565.08 13143.009999999998 22766.289999999997 True False 20162.09272953857 24063.662907656962 16290.930331812742 15734.912812478173 14696.684567460137 20116.143716583174 19755.787746078753 20993.104025147946 22302.728042529474 25688.56508394372 0.7848664440249568 0.9367460902943785 0.634170506549436 0.6125259531258544 0.5721099843231842 0.7830777488290497 0.7690498741958474 0.8172159074104686 0.8681967237037107 1.0 14.64883868574401 -8.313820665970265 0.9922008115539539 0.9939304333378307 0.7170289723337122 0.4461610561492978 0.09838403738302703 0.5362647477845444 1.1169917414740955 0.1039515956110505 0.0357911413028814 4.854889326264719e-09 8.313820665970265 -0.2769014610041185 AESSSGGGTVPSSAGILEQGPSPGDGS(ph)PPKPK ddPTM_A459_Selumetinib_30min_R2 5 AESSSGGGTVPSSAGILEQGPSPGDGSPPKPK 32 1 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 AESSSGGGTVPSSAGILEQGPS(0.012)PGDGS(0.988)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.005)PGDGS(0.995)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.057)PGDGS(0.943)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.013)PGDGS(0.987)PPKPK;AESSSGGGTVPSSAGILEQGPS(0.057)PGDGS(0.943)PPKPK 102.31 1.6146e-09 135211700.0 483463.0 344153.0 400073.0 403124.0 394791.0 353622.0 430303.0 429067.0 326791.0 386994.0 True False 456594.0619157312 370548.4284736897 374332.73874654673 348217.81577231234 345193.8251036797 402330.22063909454 450312.9421292182 430315.5139341345 392158.33130344364 375820.47768883465 1.2149259793495713 0.9859718947526058 0.9960413574283206 0.9265535979139053 0.9185072277766815 1.0705383142325975 1.1982128938223013 1.145002839069402 1.043472494407652 1.0 18.519684152837264 -6.991112319537557 24.651485584234948 1.1124156279553037 1.0011806081546106 0.16421015763547553 0.09174007046069436 247.3191223190326 685977.6778677889 0.03295923886635682 0.029023347770556204 1.0206754770756123e-07 6.991112319537557 -0.11123501980069306 AESSSGGGTVPSSAGILEQGPSPGDGS(ph)PPKPKDPVSAAVPAPGR ddPTM_A459_Selumetinib_30min_R1 1 AESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGR 44 2 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 AESSSGGGTVPSSAGILEQGPS(0.079)PGDGS(0.915)PPKPKDPVS(0.005)AAVPAPGR 81.956 1.3380000000000002e-10 71891000.0 1690.9 1523.0 3076.4 3310.3 1888.6 1740.8 1588.1 1605.3 1203.3 1595.3 True False 1730.2946800813463 1344.6864519765088 2658.6417774555894 2732.2182470269513 1717.7764634594107 1723.289132519937 1468.3083384133552 1562.7222292507145 2041.912214445222 1800.0722945379082 0.9612362155296245 0.74701802591862 1.4769638894631631 1.5178380642363767 0.9542819300490243 0.9573444009715832 0.8156940934365532 0.8681441484281479 1.134350115071015 1.0 10.813839133926407 -6.475157007226239 24.99954909842711 0.9401141171666099 1.175329467742906 0.18819441085796995 0.22357390682584607 725.0057940800666 379802.04594818724 0.07616668502475613 0.08636262476784802 3.348443635024136e-07 6.475157007226239 0.23521535057629617 AET(ph)EEAEEPEEDGEEHVCVSASK ddPTM_A459_Selumetinib_30min_R1 5 AETEEAEEPEEDGEEHVCVSASK 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AET(1)EEAEEPEEDGEEHVCVSASK;AET(1)EEAEEPEEDGEEHVCVSASK;AET(1)EEAEEPEEDGEEHVCVSASK;AET(1)EEAEEPEEDGEEHVCVSASK;AET(1)EEAEEPEEDGEEHVCVSASK 207.83 6.1009e-36 24512300.0 9257.9 8850.699999999999 5962.42 5023.969999999999 8086.1 6796.300000000001 10450.099999999999 12318.9 6462.37 12086.8 True False 9473.59105726246 7814.455929421196 5152.756113228696 4146.627951096877 7354.713682716908 6727.935392546671 9661.840543576223 11992.162754573375 10966.169897169766 13638.258515401983 0.6946334861275526 0.5729804813859599 0.3778162811189989 0.30404380049065644 0.5392707341931574 0.49331337904679445 0.7084365304166141 0.8793030826502052 0.804074060099787 1.0 13.73537181631666 -7.496891307119934 1.8553192330769845 0.897394264500335 0.4827205018680413 0.7292581672045235 0.10903934627850981 0.202028074082272 1.3631895046131504 0.07167868940514498 0.03676491731341364 3.18499454523746e-08 7.496891307119934 -0.4146737626322937 AET(ph)EEAEEPEEDGEEHVCVSASK ddPTM_A459_Selumetinib_30min_R2 3 AETEEAEEPEEDGEEHVCVSASK 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AET(1)EEAEEPEEDGEEHVCVSASK;AET(1)EEAEEPEEDGEEHVCVSASK;AET(1)EEAEEPEEDGEEHVCVSASK 156.7 2.6301e-09 56013400.0 154166.0 108194.0 141493.0 173304.0 177837.0 165686.0 240966.0 243440.0 229711.0 123751.0 True False 145598.07089539545 116492.13190145775 132389.4944259301 149699.69623392494 155495.52617704842 188507.74255224183 252171.3964650706 244148.37009633862 275659.6186616075 120177.98708628795 1.211520299394396 0.9693300306138115 1.1016118478575805 1.2456498886642224 1.2938769399208063 1.568571309293881 2.098316027576758 2.0315564939612427 2.293761323058969 1.0 16.874813137292833 -6.863183383921389 2.0182899608203404 1.940976243602823 1.127479548903754 0.4847005643105612 0.3330489540807182 0.24027235310943812 2.0052381250559232 0.13199185699846955 0.11299538268787795 1.3703030238258206e-07 6.863183383921389 -0.8134966946990692 AET(ph)FGGFDSHQMNASK ddPTM_A459_Selumetinib_30min_R2 1 AETFGGFDSHQMNASK 16 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 AET(0.992)FGGFDS(0.008)HQMNASK 81.854 0.028394 5300000.0 45125.0 31359.0 38245.0 41163.0 37706.0 29406.0 28572.0 36662.0 31157.0 29420.0 True False 42617.13314968745 33764.13446492245 35784.35833800755 35556.52838986432 32969.03518408311 33456.409578909675 29900.654614343926 36768.68035027916 37389.27059931695 28570.568157660084 1.4916445803427723 1.181780294973585 1.252490259925523 1.2445159715989484 1.153950982078869 1.1710095996092273 1.046554427946412 1.2869425678684332 1.3086638807108384 1.0 14.802242105711326 -2.675911219559775 1.5224850639504688 1.1855294112141008 199.99786853670426 0.47858968585404904 0.09527907776764577 815.4968555352625 3.8340178159222775 0.02662328371532065 564389.2987091787 0.002109059249289065 2.675911219559775 198.81233912549015 AET(ph)PPLPIPPPPPDIQPLER ddPTM_A459_Selumetinib_30min_R1 3 AETPPLPIPPPPPDIQPLER 20 0 U3KPW8;A0A669KB72;Q8IX15;Q8IX15-3 U3KPW8 HOMEZ Homeobox and leucine zipper protein Homez 1 AET(1)PPLPIPPPPPDIQPLER;AET(1)PPLPIPPPPPDIQPLER;AET(1)PPLPIPPPPPDIQPLER 156.83 3.6918e-06 15769900.0 3516.4 4259.3 4061.3999999999996 5010.1 3890.6000000000004 3618.3 4029.9 3770.7 2139.31 2995.59 True False 3598.3252782766845 3760.61917590515 3509.8841876732968 4135.18008622473 3538.695916941218 3581.9031871535426 3725.921398508898 3670.6887870402256 3630.2528209796496 3380.1031560175597 1.064560787699815 1.1125752683642691 1.0383955831125122 1.2233887237621477 1.0469195032232426 1.0597023291365295 1.1023099670421839 1.085969456436659 1.0740065179717226 1.0 11.722851560874878 -9.927686411322163 0.44677993413831957 0.9812607403929163 1.0970923555259602 0.23654580223148536 0.04947376208466043 11.197075494596257 2.1738125755816267 0.37566545986704986 0.027762727992599955 1.1811732111872616e-10 9.927686411322163 0.11583161513304385 AET(ph)PPLPIPPPPPDIQPLER ddPTM_A459_Selumetinib_30min_R2 5 AETPPLPIPPPPPDIQPLER 20 0 U3KPW8;A0A669KB72;Q8IX15;Q8IX15-3 U3KPW8 HOMEZ Homeobox and leucine zipper protein Homez 1 AET(1)PPLPIPPPPPDIQPLER;AET(1)PPLPIPPPPPDIQPLER;AET(1)PPLPIPPPPPDIQPLER;AET(1)PPLPIPPPPPDIQPLER;AET(1)PPLPIPPPPPDIQPLER 174.78 5.4933e-10 6565300.0 27409.0 27598.4 27559.4 29936.8 31188.2 21167.1 21694.800000000003 25545.5 16776.0 25335.2 True False 25885.71750692042 29715.108537157277 25786.25820840595 25859.3561961395 27270.05948995438 24082.675889197406 22703.651187430645 25619.833175714808 20131.668760604076 24603.70694724507 1.0521063985367822 1.2077492469273838 1.0480639467742194 1.0510349619911656 1.1083719842878337 0.9788230668181485 0.9227735981456575 1.0412997208367218 0.8182372194470582 1.0 14.586588076882503 -6.8406178136986515 4.353557523828748 0.9493617419139653 1.095169357090865 0.5125123307498414 0.06928426481430085 0.1783835436234038 6.330803889069799 0.024109597278425043 0.02146018881046668 1.443384995372423e-07 6.8406178136986515 0.14580761517689966 AET(ph)PTAAEDDNEGDKK ddPTM_A459_Selumetinib_30min_R2 1 AETPTAAEDDNEGDKK 16 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 AET(0.978)PT(0.022)AAEDDNEGDKK 85.93700000000003 0.019858 6012800.0 26825.0 18574.0 20553.0 19358.0 23001.0 17099.0 30992.0 29557.0 19461.0 17507.0 True False 25334.173888983194 19998.566075176794 19230.642356414406 16721.40700558738 20111.408748451056 19454.232040732382 32433.189409482937 29643.005976575252 23353.743785772298 17001.527421351293 1.4901116388617757 1.176280552890894 1.1311126276962438 0.9835238088424854 1.1829177608591939 1.1442637804589764 1.9076632708160008 1.7435495789247861 1.3736262164565052 1.0 14.053376743807707 -7.224329408365707 24.865023380837663 1.5681723173305007 1.1726574312674771 0.2641510385311707 0.25414141751174996 579.427407824935 388237.8007354497 0.09510566369499018 0.07366655145330112 5.965826125124948e-08 7.224329408365707 -0.39551488606302354 AET(ph)PTESVS(ph)EPEVATK ddPTM_A459_Selumetinib_30min_R2 1 AETPTESVSEPEVATK 16 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 2 AET(1)PT(0.002)ES(0.293)VS(0.704)EPEVATK 187.56 0.00014827 6144800.0 39654.0 36282.0 38440.0 40853.0 37421.0 34115.0 33115.0 34370.0 28028.0 34607.0 True False 37450.18942753919 39064.71273498251 35966.81225030751 35288.750924644155 32719.839432015437 38814.031584863755 34654.91311612766 34470.0110097402 33634.38316775224 33607.805990215566 1.1143300886241214 1.162370216798908 1.0701922125109486 1.0500165031575692 0.9735785621215902 1.1549112011704634 1.0311566642052428 1.0256549034999682 1.0007908037062703 1.0 15.036508742178919 -1.5228787452816932 0.235731868026211 1.0034809925189687 1.8317940298478914 0.40474794823449756 0.04830523475514788 52.80019526612424 0.6995319882683994 0.06984914324212411 17.0096658033355 0.029999999999906355 1.5228787452816932 0.8283130373289227 AET(ph)PTESVSEPEVATK ddPTM_A459_Selumetinib_30min_R2 1 AETPTESVSEPEVATK 16 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 AET(0.806)PT(0.187)ES(0.006)VSEPEVATK 101.54 0.007349 4653700.0 64432.0 55242.0 66657.0 65955.0 55846.0 56718.0 47870.0 59453.0 48340.0 59748.0 True False 60851.12738173212 59478.883768973676 62368.36119065422 56971.8152212789 48830.12621042549 64530.38966525876 50096.04985260547 59625.998387026026 58009.350732451225 58022.91999605285 1.048742934445072 1.025092907647872 1.0748918047367657 0.9818846625635963 0.8415661640907987 1.112153432982149 0.8633838120524334 1.0276283646373232 0.9997661395944474 1.0 15.824335280356339 -5.844581142223567 6.918246788460231 0.9712765541402085 1.0468355372944846 0.17505859309564042 0.0737806699043398 0.36376071679334016 25.01505479464583 0.01994338632702495 0.029856129785591625 1.430272728168451e-06 5.844581142223567 0.07555898315427612 AETFAGYDCTNS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 AETFAGYDCTNSPTK 15 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 AETFAGYDCT(0.002)NS(0.993)PT(0.004)K 151.38 0.00024757 6294100.0 2914.9 3296.7 3005.4 2460.8 3123.0 2683.5 2998.7 2872.9 1570.5 2938.3 True False 2982.8114985919433 2910.7208314057507 2597.2831874805047 2031.0674749369923 2840.5252014104312 2656.5064264230523 2772.5056447327806 2796.7013595056237 2665.0237952183365 3315.459426465705 0.8996676221647008 0.8779238280435218 0.7833856046458154 0.6126051366287174 0.8567516099687108 0.801248359493544 0.836235733304776 0.8435335800465278 0.803817345476993 1.0 11.694993084519808 -10.228843824437217 0.5464248745221105 1.0380553152931995 0.8050383675268702 0.3571114454439144 0.07517758884047977 16.77292765006274 3.6322803948267772 1.2270138158397035 0.03557502169058472 5.904133590864719e-11 10.228843824437217 -0.2330169477663293 AETFAGYDCTNS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 AETFAGYDCTNSPTK 15 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 AETFAGYDCTNS(0.5)PT(0.5)K 123.02 0.0014904000000000002 4367500.0 24941.0 16421.0 20458.0 22562.0 23726.0 17829.0 18849.0 22153.0 14940.0 20488.0 True False 23554.879066733618 17680.437898162923 19141.75455298624 19489.0166783791 20745.3277668688 20284.78291445217 19725.51584858494 22217.461562373417 17928.417458477885 19896.45820578313 1.183872969908138 0.8886223726504201 0.9620684422829825 0.9795219067036965 1.0426643552488621 1.0195172781332595 0.9914084026699534 1.1166540965525042 0.9010858753376915 1.0 14.280224017166601 -6.24056179283478 23.724653930602884 1.0170784980929557 0.9923534261662773 0.0 0.08573359767952773 2495.3566753330397 2835636.619354699 0.02423738031390392 0.03124904137081039 5.746960434013315e-07 6.24056179283478 -0.024725071926678388 AETFAGYDCTNSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 AETFAGYDCTNSPTK 15 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 AETFAGYDCTNS(0.104)PT(0.896)K 137.19 0.00094162 4080700.0 19272.0 16894.0 21009.0 15325.0 21056.0 13394.0 19474.0 18977.0 14792.0 16023.0 True False 18200.939391928565 18189.715477228223 19657.30381286968 13237.708562900447 18410.757036971663 15238.901921373741 20379.579586998934 19032.219928188526 17750.813323012375 15560.37435724634 1.169698040295061 1.1689767263701736 1.2632924736618198 0.8507320106174536 1.1831821403704161 0.9793403147962895 1.3097101084530354 1.2231209539843348 1.140770325666745 1.0 13.925589149182423 -7.262724230991603 24.994383459182313 1.186993748439725 1.1050840261300423 0.04929734614094927 0.13166649676269218 324.1519501795418 6305719.721075442 0.052248415180081755 0.037470640297005135 5.46104517343925e-08 7.262724230991603 -0.08190972230968274 AETPTESVS(ph)EPEVATK ddPTM_A459_Selumetinib_30min_R1 2 AETPTESVSEPEVATK 16 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 AETPTES(0.044)VS(0.956)EPEVATK;AETPTESVS(1)EPEVATK 287.43 1.8215999999999997e-74 110612000.0 8715.099999999999 9911.7 8662.4 8351.5 8590.5 8588.5 8193.1 9214.7 4743.0 8209.5 True False 8918.144873367397 8751.23355617568 7486.093659157229 6893.067302070984 7813.490791775957 8502.107487734074 7575.087870697348 8970.296222436036 8048.5245849860285 9263.269292301733 0.9627426982802764 0.9447240795912539 0.8081481195174331 0.7441289985814714 0.8434917031149447 0.9178301115352197 0.8177553336371908 0.9683726057592676 0.8688643642989823 1.0 13.177305739419513 -8.75405178067691 0.7328144139463945 0.9981371368751704 0.8615268117937318 0.2275727168746483 0.06978803370701799 1.5902684316202715 1.7505636255520387 0.07563867732056347 0.02768475945375716 1.7617659795621192e-09 8.75405178067691 -0.13661032508143856 AETPTESVS(ph)EPEVATK ddPTM_A459_Selumetinib_30min_R2 2 AETPTESVSEPEVATK 16 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 AETPTES(0.046)VS(0.946)EPEVAT(0.008)K;AETPTES(0.008)VS(0.992)EPEVATK 147.75 0.0003082 125584000.0 82397.0 76362.0 87686.0 96439.0 100575.0 70351.0 78061.0 78230.0 64128.0 75221.0 True False 77817.70460132512 82218.71985747019 82044.37822529828 83303.84183344587 87939.86934809205 80041.2116672065 81690.99117493708 78457.63634832622 76955.39188602866 73049.17428237064 1.0652783603072882 1.125525656726177 1.123139022874602 1.1403803349157096 1.2038448101844603 1.0957168572201545 1.1183013631223484 1.0740386475150183 1.0534738091433942 1.0 16.156580345042812 -8.222613641199398 1.092537505166943 1.003171716498126 1.1298229382740255 0.6017306420957784 0.03339323055726764 0.3313159581028391 0.787776081310966 0.03247425289750474 0.010950506760190942 5.989441932569742e-09 8.222613641199398 0.1266512217758995 AETSEGSGSAPAVPEASAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AETSEGSGSAPAVPEASASPK 21 0 I6LM39;A0A087X1U4;P51608;P51608-2;A0A087WVW7;A0A0D9SFX7;B5MCB4 I6LM39 MECP2 Methyl-CpG-binding protein 2 1 AETSEGSGSAPAVPEAS(0.083)AS(0.917)PK;AETSEGSGSAPAVPEAS(0.015)AS(0.985)PK 329.54 8.008599999999995e-156 23571000.0 7903.9 5983.6 4513.2 3555.1 4084.8 4048.6000000000004 4420.4 5357.5 5705.9 7868.3 True False 8088.0454916878225 5283.03733029983 3900.3322292330517 2934.2685224920756 3715.3305612300123 4007.874759834681 4086.9656691155415 5215.401696387407 9682.495557552556 8878.27294873229 0.9109931107538992 0.5950523666941534 0.43931204320430045 0.33049992261288313 0.41847446937982646 0.4514250443727298 0.4603334108689585 0.5874342596250213 1.0905832264297641 1.0 13.116063347428419 -8.200463200256463 4.387595483020461 1.0492786324866983 0.5040291953252435 0.6575624056237617 0.150618416658957 0.12914476491731947 4.916589087771642 0.12380493930303939 0.04145504744696771 6.3028475061718746e-09 8.200463200256463 -0.5452494371614548 AETSEGSGSAPAVPEASAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AETSEGSGSAPAVPEASASPK 21 0 I6LM39;A0A087X1U4;P51608;P51608-2;A0A087WVW7;A0A0D9SFX7;B5MCB4 I6LM39 MECP2 Methyl-CpG-binding protein 2 1 AETSEGSGSAPAVPEASAS(1)PK;AETSEGSGSAPAVPEAS(0.081)AS(0.919)PK 316.28 6.4415e-119 29413000.0 151765.0 111447.0 100690.0 104922.0 73037.0 89826.0 154398.0 112947.0 82663.0 88404.0 True False 143330.50886343088 119994.62654141418 94211.71502298281 90631.44259945439 63861.43910093556 102198.7161407584 161577.81293383305 113275.65707061745 99197.90979719906 85851.54681882344 1.6695157417012882 1.3976990629492616 1.097379354408165 1.0556762918985978 0.7438589223756837 1.1904120534535407 1.882060590880422 1.3194364139957595 1.1554586198259313 1.0 16.389556507576998 -7.038702293217987 24.990210594925955 1.3901982423145955 1.1688703318962792 0.03869853053521988 0.30916987697190773 1410.734451654748 910912.2487805438 0.12466169934699073 0.09658284951491714 9.147400765296895e-08 7.038702293217987 -0.22132791041831634 AEVDNRS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 2 AEVDNRSPQK 10 1 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 AEVDNRS(1)PQK;AEVDNRS(1)PQK 127.52 0.015538 11923800.0 5208.299999999999 5123.700000000001 4729.200000000001 4439.9 4339.8 5030.8 4078.1 4049.4 3311.3 4320.1 True False 5329.643256412368 4523.814822056495 4087.000615636124 3664.5548122451014 3947.2658562539186 4980.194719600927 3770.4856337028546 3941.9967576950376 5619.034252216792 4874.626916337503 1.0933438287451005 0.9280330371324937 0.8384232651607412 0.7517610834919904 0.8097575309865259 1.0216565913813034 0.7734921458431874 0.8086766075334466 1.1527106276347794 1.0 12.25107608987372 -8.259427187277025 24.997639505136025 1.0763553200853875 0.8732851960473577 0.3445006439402907 0.10920148093384298 193.65415279054233 2405864.6804129337 0.08523035823988909 0.028508266111448317 5.502661690224291e-09 8.259427187277025 -0.20307012403802982 AEVDNRS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 1 AEVDNRSPQK 10 1 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 AEVDNRS(1)PQK 110.98 0.04334 5266800.0 25172.0 22503.0 19764.0 20793.0 23562.0 21085.0 24769.0 32158.0 19942.0 28029.0 True False 23773.041011499896 24228.907741450606 18492.405757416163 17960.957530074313 20601.930913047414 23989.267359427016 25920.80757884238 32251.57445595652 23930.957226035214 27219.729941912097 0.8733753443635347 0.8901230024381573 0.6793750634881256 0.6598506880267972 0.7568749196635195 0.8813190803369833 0.9522801157160021 1.1848601923965654 0.8791768793116154 1.0 14.732365132894042 -7.131606002183771 2.2821894292904243 1.0257745523508814 0.7685661317574528 0.5512214600656619 0.09854863379353346 0.23584479519657428 2.40718271910041 0.04651262461001559 0.03350197469016614 7.385739705599868e-08 7.131606002183771 -0.25720842059342863 AEVPGATGGDS(ph)PHLQPAEPPGEPR ddPTM_A459_Selumetinib_30min_R1 2 AEVPGATGGDSPHLQPAEPPGEPR 24 0 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;A0A087WWC8;Q9P2K5-4 A0A0A0MQW0 MYEF2 Myelin expression factor 2 1 AEVPGATGGDS(1)PHLQPAEPPGEPR;AEVPGAT(0.001)GGDS(0.999)PHLQPAEPPGEPR 137.28 4.6465e-08 90547000.0 6945.799999999999 8618.5 5839.799999999999 6833.3 7688.1 5909.6 7962.599999999999 7165.5 3689.6 7150.0 True False 7107.623625825896 7609.442013368055 5046.787235725247 5639.9924319274 6992.7127124443 5850.154789487488 7361.974671273959 6975.44766317573 6260.981722277982 8067.772146897792 0.8809896333721955 0.9431900002646985 0.62554905416681 0.6990768119419537 0.8667464307520296 0.7251264268459765 0.9125164341812473 0.8646064286604722 0.7760484069552517 1.0 12.977954624043983 -7.273265869583038 24.46814539920442 0.8770100198165537 0.7889362422103382 0.1787666029812658 0.1019306633596409 1226.18073767342 2536865.4520822084 0.044234287441607276 0.03009746035760914 5.330084945368372e-08 7.273265869583038 -0.08807377760621549 AEVPGATGGDS(ph)PHLQPAEPPGEPR ddPTM_A459_Selumetinib_30min_R2 3 AEVPGATGGDSPHLQPAEPPGEPR 24 0 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;A0A087WWC8;Q9P2K5-4 A0A0A0MQW0 MYEF2 Myelin expression factor 2 1 AEVPGAT(0.093)GGDS(0.907)PHLQPAEPPGEPR;AEVPGAT(0.035)GGDS(0.965)PHLQPAEPPGEPR;AEVPGAT(0.044)GGDS(0.956)PHLQPAEPPGEPR 102.28 2.1954e-06 381066900.0 157960.0 151960.0 190107.0 195995.0 192837.0 144215.0 160042.0 170655.0 148111.7 158794.0 True False 149181.2155639806 163614.8433715873 177875.72259285118 169300.1428897662 168611.09207534706 164079.30719657405 167484.27011720662 171151.57779654383 177738.1785866697 154209.20462363944 0.9673950133396377 1.0609927194093447 1.1534702032020194 1.0978601653705269 1.0933918794721538 1.0640046266824568 1.0860847802565747 1.1098661601572597 1.1525782719679718 1.0 17.23452935556881 -4.828531968701173 3.5780420261865036 1.0977588333161719 0.9587993307631776 0.4569503638992769 0.04153584266066451 0.21121421945136873 4.540396573711129 0.01006544299871952 0.07278611228940268 1.4841166292467849e-05 4.828531968701173 -0.13895950255299427 AFAAVPTSHPPEDAPAQPPTPGPAAS(ph)PEQLSFR ddPTM_A459_Selumetinib_30min_R1 3 AFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFR 33 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 AFAAVPTSHPPEDAPAQPPT(0.148)PGPAAS(0.797)PEQLS(0.055)FR;AFAAVPTSHPPEDAPAQPPT(0.016)PGPAAS(0.888)PEQLS(0.096)FR;AFAAVPTSHPPEDAPAQPPT(0.02)PGPAAS(0.924)PEQLS(0.056)FR 115.9 1.2399e-18 127298000.0 6724.6 7772.5 8729.9 8078.3 9339.7 7468.6 7995.0 8135.900000000001 3499.91 6389.599999999999 True False 6881.270096206169 6862.492086662783 7544.42752990819 6667.5765534718375 8494.925784057958 7393.472664946235 7391.930713188572 7920.109502872296 5939.091646687425 7209.76739997456 0.9544371842329407 0.9518326606052502 1.0464176042537532 0.9247977339040597 1.1782524057694195 1.0254800543180247 1.0252661844839341 1.098524968073206 0.8237563456913161 1.0 12.815737000949792 -2.5767232671807703 18.646751586165443 1.009357417658084 0.37809048306295034 0.0 0.09293752943345149 0.0 0.0 0.020497887139852684 0.0 0.002650188302976899 2.5767232671807703 -0.6312669345951336 AFAAVPTSHPPEDAPAQPPTPGPAAS(ph)PEQLSFR ddPTM_A459_Selumetinib_30min_R2 2 AFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFR 33 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 AFAAVPTSHPPEDAPAQPPT(0.01)PGPAAS(0.945)PEQLS(0.045)FR;AFAAVPTSHPPEDAPAQPPT(0.008)PGPAAS(0.947)PEQLS(0.045)FR 129.82 7.0802e-25 98738000.0 220385.0 137200.0 216605.0 222723.0 191695.0 127637.0 231329.0 176677.0 160293.0 163635.0 True False 208136.8839710552 147722.79883246758 202668.87012169222 192387.7431813946 167612.5603249564 145217.83817667485 242086.25686971762 177191.10081954813 192356.07896062918 158910.4323752107 1.3097748263601328 0.9295978660713258 1.275365418698009 1.210667797612803 1.0547612124621166 0.9138345167534021 1.5234132413542032 1.1150375602853695 1.2104685393243941 1.0 17.27785431430219 AFEDDDITHVEGSVDPIR ddPTM_A459_Selumetinib_30min_R2 1 AFEDDDITHVEGSVDPIR 18 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 114.58 0.0015237 2402700.0 9823.0 7604.7 11741.0 11550.0 13384.0 11405.0 11117.0 14819.0 10858.0 9245.5 False True 9277.076984584603 8187.9560370354775 10985.596842634244 9976.870075138664 11702.582265521887 12975.935225718049 11633.962527917598 14862.120836582491 13029.903397868327 8978.558392306124 1.0332479424017873 0.9119455127731723 1.2235368265854332 1.1111884156913219 1.303392120894377 1.4452136588917597 1.2957494978132496 1.6552903247049202 1.4512244425601628 1.0 13.132268107442597 -5.993507548887074 1.0027068739194134 1.4126807219038346 0.9782485034636456 0.41422538721488666 0.16960190297172803 0.49645883184799033 1.0120647417165052 0.06883380977002189 0.14860634430537098 1.015061722662321e-06 5.993507548887074 -0.4344322184401891 AFFS(ph)EVER ddPTM_A459_Selumetinib_30min_R1 2 AFFSEVER 8 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 AFFS(1)EVER;AFFS(1)EVER 114.86 0.010127 5507900.0 1600.54 2961.2 2916.7 3053.7 2883.3 2767.8 2840.5 2564.4 865.79 1930.74 True False 1637.8294678912982 2614.501327375467 2520.628160286281 2520.428620048394 2622.5060240879593 2739.958444961328 2626.238798100329 2496.383781654853 1469.182395200307 2178.5692860002005 0.7517913147937162 1.200100150211714 1.157010785236072 1.1569191929056517 1.2037744408408584 1.2576870804930076 1.2054878469906452 1.1458822070507346 0.6743794675898005 1.0 11.089165281311708 -8.239808188381273 23.667114435883562 0.837189800374442 1.1472313297806256 0.378053795508666 0.15204112346251386 337.31334427670527 369063.038355643 0.0997984423380452 0.03762649223068917 5.7569414375362884e-09 8.239808188381273 0.31004152940618357 AFFSEVER ddPTM_A459_Selumetinib_30min_R2 1 AFFSEVER 8 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 157.33 0.0075260000000000014 8893100.0 29748.0 28031.0 30997.0 39004.0 31906.0 25536.0 25060.0 28326.0 23472.0 32996.0 False True 28094.725250679297 30180.887566129055 29002.686766981813 33691.587914347074 27897.683036740957 29053.35220727189 26225.339655447962 28408.423970378262 28167.05586247609 32043.31974609627 0.8767732392678191 0.9418776770096017 0.9051086777772179 1.0514387454643057 0.8706239945734598 0.9066898323108786 0.8184339158130739 0.8865630713509066 0.8790305151171981 1.0 14.967736000864338 AFGFSHLEALLDDSK ddPTM_A459_Selumetinib_30min_R1 2 AFGFSHLEALLDDSK 15 0 J3KR44;F5H6Q1;F5GYJ8;Q96FW1;F5GYN4 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 ; 103.3 0.0080683 6807300.0 4229.7 5301.700000000001 4738.1 4893.9 4387.3 4480.7 4892.6 4783.6 3415.4 4827.7 False True 4328.243780436494 4680.97449930654 4094.6920445203245 4039.272234880583 3990.469489640727 4435.628226150094 4523.547242945144 4656.723388677334 5795.684349053613 5447.382320780205 0.7945548018404146 0.8593071357319572 0.7516806795256954 0.7415070206238168 0.7325480854204464 0.8142678381925647 0.8304075198998068 0.854855252386686 1.0639393396246002 1.0 12.411347409952674 -8.08302086195725 2.391408570404767 1.0343953396888432 0.7863242981871144 0.83546906646364 0.042158242459070044 0.1225163524443011 1.268101172970694 0.038326321197667414 0.012319846656129093 8.259982706145964e-09 8.08302086195725 -0.24807104150172887 AFGPGLQGGSAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 1 AFGPGLQGGSAGSPAR 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 AFGPGLQGGSAGS(1)PAR 147.75 0.0003082 106780000.0 1222.4 1534.0 1444.8 1357.0 1369.0 1310.2 1589.4 1111.8 753.88 1175.1 True False 1250.879541623654 1354.3985668627474 1248.6040957183184 1120.0254240448219 1245.1741917165814 1297.0205775664185 1469.5102783667187 1082.3114523646334 1279.2792987833175 1325.9355314432992 0.9433939373070833 1.0214663795821701 0.94167783131899 0.8447057926154665 0.9390910509511666 0.9781927905307686 1.1082818459258998 0.8162625004750589 0.9648125934077687 1.0 10.372794916275408 -6.749916085535654 21.541925206237554 0.9704495814524926 0.9377141137191005 0.04945383614193932 0.07710460906318188 175.99196975077447 328998.721071641 0.026766461962314293 0.026457785179675005 1.778623042730062e-07 6.749916085535654 -0.03273546773339209 AFGPGLQGGSAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 6 AFGPGLQGGSAGSPAR 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 AFGPGLQGGS(0.216)AGS(0.784)PAR;AFGPGLQGGS(0.005)AGS(0.995)PAR;AFGPGLQGGSAGS(1)PAR;AFGPGLQGGS(0.021)AGS(0.979)PAR;AFGPGLQGGSAGS(1)PAR;AFGPGLQGGSAGS(1)PAR 208.07 6.586000000000001e-08 565773000.0 249057.0 262358.0 283441.0 339587.0 307091.0 222954.0 245478.0 254718.0 237200.0 257040.0 True False 235215.4089941651 282480.01498606836 265204.7146472275 293334.66477974964 268511.48315162724 253663.8897250981 256893.21340542927 255459.18720916475 284646.62792175007 249618.58732987524 0.9422992554770127 1.131646557284479 1.0624397705478354 1.175131499290567 1.0756870552944229 1.0162059341753942 1.029142966288566 1.0233980968395235 1.140326251208147 1.0 17.929365839927904 -6.573064447840292 10.218406802622352 1.0428042410322187 1.0861902611093974 0.06192985958978692 0.06622626236484054 1.1735673824654198 231.44561999671373 0.02139919960681197 0.02140479848466358 2.672609772933801e-07 6.573064447840292 0.04338602007717873 AFGS(ph)GYR ddPTM_A459_Selumetinib_30min_R1 1 AFGSGYR 7 0 E7EX17;P23588;P23588-2;F8VX11;F8VP89 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 AFGS(0.994)GY(0.006)R 85.161 0.036582 12843000.0 4164.8 4150.2 4042.8 5418.1 4031.0 3152.1 3348.6 3856.1 1653.2 3337.1 True False 4261.8317367099135 3664.2926546243652 3493.8099655108113 4471.93054533327 3666.3967617308526 3120.3927358778087 3096.0124060266726 3753.8237016219286 2805.3596550493185 3765.449291106661 1.131825555791077 0.9731355732976646 0.9278600494667623 1.187622033815512 0.973694366404096 0.828690680617486 0.8222159340557096 0.9969125624630798 0.7450265395088688 1.0 11.878606301320017 -6.5499355737591225 6.652285358489683 0.8768404293537028 1.0451628353036788 0.41074196550841013 0.09953034709561184 0.17734597138083277 27.007009576133306 0.031908443386584856 0.03236377418908932 2.818801060653845e-07 6.5499355737591225 0.16832240594997605 AFHAALRNS(ph)PVNTK ddPTM_A459_Selumetinib_30min_R1 1 AFHAALRNSPVNTK 14 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 AFHAALRNS(0.969)PVNT(0.031)K 67.87899999999999 0.035744 28349000.0 2306.1 2261.0 3072.3 3724.3 2740.3 2593.0 2510.8 2398.4 1668.3 2131.8 True False 2359.8276431105287 1996.2810688896182 2655.0985349359016 3073.920918769438 2492.440348839261 2566.9167742556256 2321.408334543324 2334.7866408988452 2830.9832521889534 2405.43729549045 0.9810389352217048 0.8299035990803459 1.1037903752109852 1.2779052376597864 1.0361693291743328 1.0671310281369237 0.9650670748704787 0.970628768946064 1.1769100186050527 1.0 11.232083476655886 -5.271412245439378 24.810335425385606 1.075346680795657 0.9054712648943575 0.3277403723121157 0.09694431195631154 659.8436549240315 1641550.7477255503 0.026622226321563473 0.0564991987854593 5.352883044533769e-06 5.271412245439378 -0.16987541590129962 AFHAALRNS(ph)PVNTK ddPTM_A459_Selumetinib_30min_R2 1 AFHAALRNSPVNTK 14 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 AFHAALRNS(0.999)PVNT(0.001)K 73.082 0.021408 12953000.0 99918.0 109250.0 93301.0 109290.0 112100.0 85907.0 78270.0 78756.0 60336.0 99167.0 True False 94364.95756344526 117629.12370588293 87298.11523844814 94404.51346423417 98016.99581328472 97739.90946389842 81909.71008906262 78985.16692124229 72404.88592869624 96303.79104319074 0.9798675269296934 1.2214381431062056 0.9064867986276501 0.9802782677775917 1.01778958804774 1.0149123768145702 0.8505346383750085 0.8201667459364989 0.7518383767075565 1.0 16.555304971092312 -7.265702142243361 4.74619836448492 0.8387287383829727 1.0231241300801859 0.4138228865549324 0.09517159832638387 0.17878570889847245 11.65672042382867 0.039107283378424465 0.02763425315664515 5.4237274532874706e-08 7.265702142243361 0.1843953916972132 AFHNEAQVNPER ddPTM_A459_Selumetinib_30min_R1 2 AFHNEAQVNPER 12 0 F5H282;E7EQR6;P17987 F5H282 TCP1 T-complex protein 1 subunit alpha 0 ; 128.36 0.0034588 19957600.0 8182.1 9377.8 7250.0 8515.3 8585.0 7636.9 8519.0 7383.0 4359.0 7085.6 False True 8372.727010404855 8279.84281637906 6265.489821399371 7028.262706977794 7808.488265804855 7560.079719750403 7876.404971313754 7187.178856636164 7396.904631236374 7995.105779588667 1.047231549053453 1.0356139173939787 0.7836656567315259 0.879070634052247 0.9766585309902662 0.9455884547583001 0.9851533160977114 0.8989473128654378 0.9251790826983819 1.0 12.964901406132354 -10.875413989907727 15.869238285941988 0.9999969854260135 0.9392947998950835 0.052117300265638766 0.07358052035681781 0.0 0.0 0.07518305471196689 0.018234569166707713 1.332250862551311e-11 10.875413989907727 -0.060702185530929986 AFHNEAQVNPER ddPTM_A459_Selumetinib_30min_R2 2 AFHNEAQVNPER 12 0 F5H282;E7EQR6;P17987 F5H282 TCP1 T-complex protein 1 subunit alpha 0 ; 136.27 0.001996 20083500.0 157957.0 147399.0 155811.0 168343.0 167538.0 140830.0 146890.0 153536.0 124923.0 159161.0 False True 149178.38229197098 158704.0293375141 145786.2898941896 145414.39299212716 146490.37863127666 160228.0541725448 153720.67605701296 153982.76434074691 149911.0906402566 154565.60838005866 0.9651460234618225 1.0267745263699253 0.9432000522116035 0.9407939742621804 0.9477553264699999 1.0366345777164274 0.9945335037211633 0.9962291479623423 0.9698864592933432 1.0 17.23785982255403 -6.737574963879547 24.999950090822797 0.9989133888072549 0.9656543509802723 0.28706581502310724 0.02733417087483687 349.59197256562743 366225.58546718495 0.009603098370046215 0.00959792895107679 1.8298902203961777e-07 6.737574963879547 -0.033259037826982585 AFKPEETSSNSDPPS(ph)PPVLNNSHPVPR ddPTM_A459_Selumetinib_30min_R1 2 AFKPEETSSNSDPPSPPVLNNSHPVPR 27 1 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 AFKPEETSSNSDPPS(0.999)PPVLNNSHPVPR;AFKPEETSSNSDPPS(1)PPVLNNSHPVPR 126.62 3.0298e-12 27733000.0 6388.0 9064.099999999999 9581.4 11401.2 8353.0 8113.0 7483.299999999999 6722.700000000001 4299.1 6269.0 True False 6536.827971115759 8002.87095821423 8280.298506862884 9410.194447030084 7597.472624841926 8031.390586014616 6918.828656160602 6544.392157592834 7295.258706159278 7073.6872152310825 0.9241047521921302 1.1313577650114959 1.1705774166878233 1.3303096618080634 1.0740470130603212 1.1353895559194933 0.9781078022877462 0.9251740935761806 1.031323337346767 1.0 12.78824671192659 -7.261157693621412 8.199045145415573 0.9772276441957759 1.1366359246904219 0.3432966514860325 0.09691792317725664 0.12992132901323045 105.37850910909565 0.04053197145004716 0.02929152699218654 5.480779200590497e-08 7.261157693621412 0.15940828049464595 AFKPEETSSNSDPPS(ph)PPVLNNSHPVPR ddPTM_A459_Selumetinib_30min_R2 3 AFKPEETSSNSDPPSPPVLNNSHPVPR 27 1 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 AFKPEETSSNS(0.007)DPPS(0.993)PPVLNNSHPVPR;AFKPEETSSNSDPPS(1)PPVLNNSHPVPR;AFKPEETSSNSDPPS(1)PPVLNNSHPVPR 187.18 2.2953e-27 12701000.0 65912.0 59901.0 67018.0 66156.0 63171.0 52280.0 49171.0 51813.0 45747.0 63580.0 True False 62248.874906641555 64495.21408792749 62706.134843681335 57145.43867453459 55234.89422409463 59481.09544941166 51457.5489304881 51963.767251896104 54897.67827797774 61744.280199321125 1.0081723311971815 1.0445536635899857 1.0155780363987592 0.9255179344557798 0.8945750771696895 0.9633458396048424 0.833397826719727 0.8415964536981911 0.8891135842989605 1.0 15.914017875594471 -5.817682493840146 2.817991960346078 0.8955681731030147 1.028705732661586 0.5513036601168164 0.04798690295764393 0.18500397900481177 2.9844687533501855 0.014280923150623818 0.02425948609505951 1.521659585602299e-06 5.817682493840146 0.13313755955857132 AFLAELEQNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AFLAELEQNSPK 12 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 AFLAELEQNS(1)PK 135.91 0.0014508 38532000.0 4269.3 4400.8 5755.1 6275.0 3798.7 4090.4 4128.0 3891.6 3099.6 4660.7 True False 4368.766383388305 3885.552290123584 4973.589030501451 5179.189046338436 3455.108255714957 4049.254289786044 3816.621636528133 3788.382126301677 5259.794814173036 5258.94624406245 0.8307303746108469 0.7388461698977281 0.9457387087987107 0.984833996389664 0.6569963059835239 0.7699744591148475 0.7257388570642348 0.7203690531309204 1.000161357441435 1.0 12.360558034604693 -8.276021630957924 24.120487450875668 1.000080794573434 0.7980604110873938 0.41523883857090216 0.09655111668922656 610.0101193136434 1009001.552221488 0.09794954332259877 0.025804108162015893 5.296370635372493e-09 8.276021630957924 -0.20202038348604023 AFLAELEQNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AFLAELEQNSPK 12 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 AFLAELEQNS(1)PK 150.34 0.00055203 6310100.0 42461.0 37464.0 41207.0 42569.0 35306.0 25555.0 34793.0 34570.0 24469.0 36664.0 True False 40101.18760485053 40337.36833425344 38555.786482789306 36771.028764379065 30870.544640355336 29074.96928480708 36410.94344102156 34670.59297662842 29363.483720983622 35605.41505548772 1.1262665395799085 1.1328998207545513 1.082862997740757 1.0327369785487641 0.867018249674845 0.8165884104846539 1.022623760579072 0.973744946452598 0.8246915160298895 1.0 15.119809049943445 -5.968377039348111 2.6824843825014604 0.9170091779125125 1.1184832649229384 0.6387390067708287 0.06675392895937432 0.17994153900650858 2.6259473739873784 0.021111259734366068 0.03247945632969877 1.075531069565611e-06 5.968377039348111 0.2014740870104259 AFLSPPTLLEGPLRLS(ph)PLLPGGGGR ddPTM_A459_Selumetinib_30min_R1 1 AFLSPPTLLEGPLRLSPLLPGGGGR 25 1 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5 G3V599 MIA2 Melanoma inhibitory activity protein 2 1 AFLS(0.007)PPT(0.18)LLEGPLRLS(0.813)PLLPGGGGR 46.2 0.033368 5655500.0 218.79 441.51 495.35 406.57 432.12 468.94 489.19 444.64 138.47 374.9 True False 223.8873813087691 389.8178039475694 428.0841907627832 335.5701817641141 393.0348222969825 464.22288936345336 452.29000445087166 432.8467028057298 234.97347655134217 423.0220668352421 0.5292569793905536 0.9215070193947944 1.0119665717805513 0.7932687395591858 0.9291118669940711 1.097396390775657 1.0691877325327068 1.0232248781818614 0.5554638752281905 1.0 8.724589112891596 -4.762600342422989 5.632557453607883 0.9427260738462913 0.5108562615239726 0.392605917184633 0.15065622203204762 0.1498276318110205 15.889128615379752 0.037663145681947126 0.25180902780365044 1.727426817669384e-05 4.762600342422989 -0.4318698123223187 AFMES(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AFMESPK 7 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AFMES(1)PK 83.948 0.038343 7285800.0 4364.3 11925.0 5614.9 8048.5 4481.5 5895.0 5622.3 4404.8 3684.5 5660.0 True False 4465.9796985504845 10528.815456217904 4852.427420437973 6642.980564056559 4076.149116273087 5835.701652231751 5198.205384460299 4287.970395193141 6252.327394767242 6386.516133068738 0.6992826144172863 1.6486007765173813 0.7597925565884961 1.0401571726500265 0.6382429843349486 0.9137535286280849 0.8139344325060911 0.6714099371002074 0.9789887419830227 1.0 12.640813435210113 AFMES(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AFMESPK 7 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AFMES(1)PK;AFMES(1)PK 82.75 0.040577 32047000.0 237930.0 279480.0 201252.0 143299.0 118238.0 128481.0 164062.0 142465.0 87311.0 205036.0 True False 224706.80310925512 300915.21733016067 188303.6654266099 123781.42899543662 103383.88537886862 146178.0915156054 171691.2080826857 142879.5495636496 104775.63967317023 199116.07793249414 1.1285216414589934 1.511255245958487 0.9456979435405013 0.6216546161450707 0.5192141511240425 0.7341350484271985 0.8622669242254449 0.7175691237354008 0.5262038141826602 1.0 17.603250192818038 -5.485176654515716 4.2691614105028055 0.7017885716650355 1.3138266072004765 0.6887030587221639 0.16204926352187726 0.10819208822032682 4.362579606406007 0.04288855673567656 0.08920187902727335 3.272075721817347e-06 5.485176654515716 0.612038035535441 AFMGT(ph)PVQK ddPTM_A459_Selumetinib_30min_R1 2 AFMGTPVQK 9 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AFMGT(1)PVQK;AFMGT(1)PVQK 151.15 0.0029099 98374000.0 5053.6 9419.8 7688.9 9330.2 6821.8 6511.299999999999 7812.9 5855.4 3462.5 5759.8 True False 5171.339047406165 8316.925436853786 6644.789612104495 7700.855719545316 6204.769394486611 6445.802233787376 7223.566662798122 5700.095770980277 5875.609609005719 6499.126435203065 0.7956975601205682 1.2796989748967584 1.0224127316730496 1.1849062787627862 0.9547082144575548 0.9917951740211033 1.111467323311494 0.877055682453757 0.9040614408084117 1.0 12.666030099373035 -7.765132347079948 24.99993924957863 0.9179189038359001 1.0559838540988344 0.1585229505563286 0.12712196751538188 153.74875541271768 1040786.016431514 0.06274998888199763 0.031991858233299954 1.717384950805675e-08 7.765132347079948 0.1380649502629343 AFMGT(ph)PVQK ddPTM_A459_Selumetinib_30min_R2 1 AFMGTPVQK 9 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AFMGT(1)PVQK 99.522 0.043808 6478400.0 38493.0 40612.0 47988.0 39929.0 48253.0 36643.0 34918.0 32221.0 34836.0 46060.0 True False 36353.71315968797 43726.80981183809 44900.50432538385 34490.601318633075 42191.026752706755 41690.24063796461 36541.756188704356 32314.757775526283 41804.17339916568 44730.12812174792 0.8127343847694612 0.9775695185316937 1.0038089808992319 0.771082104320279 0.9432350973346163 0.9320393745461841 0.8169383304524372 0.722438301262427 0.9345864891194079 1.0 15.448959270249341 -7.25802872195506 24.747344436941333 0.845360639020455 0.9098683673047258 0.014152310895742315 0.09565674549457379 673.3114610230552 4885496.935356756 0.03695006190862668 0.027440381329313666 5.520409289870928e-08 7.25802872195506 0.06450772828427076 AFQLEEGEET(ph)EPDCK ddPTM_A459_Selumetinib_30min_R1 6 AFQLEEGEETEPDCK 15 0 P38432 P38432 COIL Coilin 1 AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK 268.93 1.7897e-44 147278500.0 23059.0 24308.899999999998 20088.41 19663.329999999998 15923.529999999999 22396.6 20584.800000000003 20241.72 16103.630000000001 18624.25 True False 23596.22983499661 21462.80268709899 17360.514259737552 16229.498541918396 14483.249523027556 22171.310538485766 19032.071963082435 19704.843831227045 27326.68394740008 21014.853903057512 1.1228357781523062 1.0213158171885413 0.8261068261441361 0.7722870031257805 0.6891910640844544 1.055030438982019 0.9056485498723074 0.9376626609980919 1.300350888636168 1.0 14.359121806343069 -8.123190511610545 6.953823584339222 1.1480136421319291 0.9066119978419508 0.30575739525397494 0.14105820439482156 0.30348161673634855 15.710125003104803 0.1009735407353185 0.037658381431348975 7.530251623291718e-09 8.123190511610545 -0.24140164428997835 AFQLEEGEET(ph)EPDCK ddPTM_A459_Selumetinib_30min_R2 5 AFQLEEGEETEPDCK 15 0 P38432 P38432 COIL Coilin 1 AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK;AFQLEEGEET(1)EPDCK 208.38 3.8075e-06 85408200.0 269521.0 197572.0 195933.0 224362.0 188662.0 209915.0 183307.0 180158.0 122819.3 175193.0 True False 254542.10179804786 212725.13710589192 183326.88409572036 193803.50855396237 164960.59290032042 238828.88583135503 191831.13871592944 180682.22995323752 147386.5918579671 170134.72288392042 1.496120824034944 1.2503334622117679 1.0775394992167513 1.1391179017947484 0.9695880423708086 1.4037633340391267 1.127524913575767 1.0619950289425248 0.8662934253493103 1.0 17.376318085868327 -4.819317221457119 1.98755865868403 1.0930595265072698 1.5974915883441196 0.4822368738069579 0.133119839374977 0.6355478557652078 2.9399687076901135 0.03684112245060573 0.5784281209976202 1.5159426738674118e-05 4.819317221457119 0.5044320618368499 AFQLEEGEET(ph)EPDCKYSK ddPTM_A459_Selumetinib_30min_R1 1 AFQLEEGEETEPDCKYSK 18 1 P38432 P38432 COIL Coilin 1 AFQLEEGEET(1)EPDCKYSK 105.72 0.0023698 17180000.0 1371.5 786.51 3137.8 3089.1 1643.8 1707.4 1267.8 1091.1 1262.5 820.02 True False 1403.4532815255568 694.4250435614209 2711.703994701647 2549.646674588693 1495.118580236461 1690.225106195163 1172.1688252883648 1062.1604836077086 2142.370290648295 925.2775546712062 1.5167916636908678 0.7505045810910027 2.9306925051967143 2.755547956088376 1.6158595576953616 1.826722260431118 1.2668294171524461 1.1479371549060684 2.315381238670139 1.0 9.853742384251127 -6.9259695892363125 2.3812306166402206 1.4552857946136528 1.9610295288283572 0.10231373658031828 0.6663663689606488 0.7833539776422683 9.014590089590557 0.2912121212792773 0.24251779394266493 1.185851782599433e-07 6.9259695892363125 0.5057437342147044 AFRLHS(ph)S(ph)LIQHQR ddPTM_A459_Selumetinib_30min_R1 3 AFRLHSSLIQHQR 13 1 Q9Y2G7 Q9Y2G7 ZFP30 Zinc finger protein 30 homolog 2 AFRLHS(1)S(1)LIQHQR;AFRLHS(1)S(1)LIQHQR;AFRLHS(1)S(1)LIQHQR 106.42 0.01374 327291000.0 15259.3 16409.5 10887.900000000001 14347.500000000002 42757.0 10527.5 24486.299999999996 16383.9 3647.53 6635.55 True False 15614.81200057086 14488.268111430407 9409.382982953688 11841.97846093079 38889.63689936145 10421.60290820522 22639.27867696678 15949.345749592465 6189.59200494921 7487.287478230437 2.0855098787072754 1.9350489951875867 1.2567145325075089 1.5816112971969858 5.194088915703384 1.3919063397133358 3.0236956631879455 2.130190111701437 0.826680159262707 1.0 12.870227433187301 AFRLHS(ph)S(ph)LIQHQR ddPTM_A459_Selumetinib_30min_R2 3 AFRLHSSLIQHQR 13 1 Q9Y2G7 Q9Y2G7 ZFP30 Zinc finger protein 30 homolog 2 AFRLHS(1)S(1)LIQHQR;AFRLHS(1)S(1)LIQHQR;AFRLHS(1)S(1)LIQHQR 120.92 0.005802300000000001 371548000.0 64219.7 79295.6 287452.0 341087.0 537472.0 269853.0 108250.0 199606.0 373096.0 250674.0 True False 60650.62616582789 85377.31754445963 268957.6512740737 294630.36219210643 469949.9622993563 307022.8012683644 113283.83949330566 200186.820413448 447725.6251732447 243436.39029072993 0.2491436308819498 0.3507171521993719 1.10483749349415 1.2102971204931063 1.930483613144719 1.2612033924003507 0.46535293822757406 0.8223372856226218 1.8391893859358384 1.0 17.893185321074185 -5.266930919749142 3.5067608529005256 1.2087745002233137 0.26180419528677035 0.4426152447354226 0.4082917551981256 0.22786778051179463 6.040857935697139 0.11701574162655291 0.3178920034894514 5.408403438759248e-06 5.266930919749142 -0.9469703049365433 AFS(ph)DPFVEAEK ddPTM_A459_Selumetinib_30min_R1 2 AFSDPFVEAEK 11 0 A0A087WYC1;P34932;A0A087WTS8;P34932-2 A0A087WYC1 HSPA4 Heat shock 70 kDa protein 4 1 AFS(1)DPFVEAEK;AFS(1)DPFVEAEK 190.35 1.9799e-05 39121000.0 9952.1 9916.5 11866.2 11097.5 9433.8 8755.0 10005.8 9222.900000000001 5464.6 8149.200000000001 True False 10183.964566584398 8755.47156994422 10254.83521637092 9159.529950875023 8580.51445567267 8666.932648903974 9251.054450284204 8978.278731798675 9273.027081407272 9195.229199929998 1.107526995266407 0.9521754574655817 1.1152343235173507 0.9961176335816353 0.9331485131156918 0.9425466685452446 1.0060711102616813 0.9764061924489088 1.0084606788787676 1.0 13.166669820308682 -5.983830871131985 24.91336876570801 0.9751904319374517 1.0490281729854254 0.35951429967236037 0.0476408140916242 259.05252026557696 399144.53935383435 0.012845389669555379 0.019046989169224572 1.0379325429399928e-06 5.983830871131985 0.07383774104797369 AFS(ph)DPFVEAEK ddPTM_A459_Selumetinib_30min_R2 2 AFSDPFVEAEK 11 0 A0A087WYC1;P34932;A0A087WTS8;P34932-2 A0A087WYC1 HSPA4 Heat shock 70 kDa protein 4 1 AFS(1)DPFVEAEK;AFS(1)DPFVEAEK 136.38 0.0014205 4851300.0 39260.0 36222.0 42756.0 44231.0 42782.0 34059.0 35392.0 38256.0 31439.0 37313.0 True False 37078.086370232224 39000.11092791288 40005.12550921297 38206.66149726911 37407.34268406735 38750.31809318114 37037.798127917566 38367.31862637827 37727.678479055285 36235.67673918323 1.0232480722552109 1.0762903976825784 1.1040258968298409 1.0543934855218136 1.0323345953579817 1.0693968370481326 1.0221362331524213 1.0588271581772337 1.0411749379102582 1.0 15.145123217963357 -9.72579081858099 0.256698922047884 0.977258344800261 1.0685773221972552 0.3487151103820566 0.023434821100430575 9.280629686495864 0.8708816725537437 0.2314229733337697 0.04258992706269669 1.880222222845372e-10 9.72579081858099 0.09131897739699424 AFS(ph)EDEALAQQENR ddPTM_A459_Selumetinib_30min_R1 1 AFSEDEALAQQENR 14 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 AFS(1)EDEALAQQENR 211.13 1.7074e-30 0.0 949.77 942.19 1272.6 1199.6 912.72 921.69 981.34 904.97 617.1 709.12 True False 971.8977930692887 831.8779567877524 1099.787909891425 990.1123792808907 830.1646371538039 912.4186354275629 907.3167337186339 880.9672558431566 1047.1736287992583 800.1424594137288 1.2146559423698207 1.0396623088809416 1.374490126042366 1.237420121419821 1.0375210406432782 1.1403202325947055 1.1339439909031106 1.1010130077194613 1.3087339841539358 1.0 9.644113073765332 -6.225991865240241 24.552368138222977 1.126993654214172 1.2152027243287602 0.16074884120921606 0.1071186354361112 1036.4758075432176 717904.0997773274 0.03145416535736242 0.040605432547227115 5.943032903923176e-07 6.225991865240241 0.08820907011458812 AFS(ph)PQPPK ddPTM_A459_Selumetinib_30min_R2 2 AFSPQPPK 8 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 AFS(1)PQPPK;AFS(1)PQPPK 89.24700000000001 0.029935000000000007 10520500.0 124401.0 117001.0 132751.0 138839.0 140511.0 100897.0 112965.0 118700.0 84003.0 106253.0 True False 117487.29043665976 125974.60048248935 124209.94518836003 119928.88868936607 122858.75199572227 114794.6458982266 118218.09633590098 119045.39734815729 100805.94723992763 103185.19981155201 1.13860602732977 1.2208591998906608 1.2037573742669072 1.1622683185998883 1.1906625390085035 1.1125107680934574 1.145688495557538 1.1537061280645955 0.9769419201981522 1.0 16.654876529600017 -8.23561014148639 5.578786741207832 0.9870630334592188 1.167988922272145 0.8419372493483994 0.030777509663935027 0.06330938436938444 6.419620457922019 0.025100726845440745 0.008468623496588694 5.8128599358832435e-09 8.23561014148639 0.18092588881292615 AFS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 3 AFSPVR 6 0 Q14602;Q02363 Q14602 ID2B;ID2 Putative DNA-binding protein inhibitor ID-2B;DNA-binding protein inhibitor ID-2 1 AFS(1)PVR;AFS(1)PVR;AFS(1)PVR 101.6 0.030237 41672000.0 252797.0 271923.0 257636.0 287347.0 293334.0 258694.0 217076.0 200558.0 196215.0 272875.0 True False 238747.5547665715 292778.61972974543 241059.98025286692 248209.84289877658 256482.76048076784 294326.7503096806 227170.4641279336 201141.5905758358 235463.48270517035 264996.3897356043 0.900946443099764 1.1048400320542495 0.9096726958936326 0.9366536772309381 0.9678726594602637 1.1106821138330984 0.8572587134284703 0.7590352109193694 0.8885535495034483 1.0 18.015613179222008 -7.3791334080236215 14.07254730848522 0.8559260348194628 0.9868600393189983 0.2714549222632159 0.08756784250264596 1.1172169427620036 128.48230565713408 0.03559727919823419 0.023996536483046216 4.1770203583624406e-08 7.3791334080236215 0.13093400449953552 AFS(ph)SGVDLSMASPKLVT(ph)S(ph)DT(ph)AAGK ddPTM_A459_Selumetinib_30min_R1 1 AFSSGVDLSMASPKLVTSDTAAGK 24 1 J3QS68;Q8IUD6-3;Q8IUD6 J3QS68 RNF135 E3 ubiquitin-protein ligase RNF135 4 AFS(0.485)S(0.485)GVDLS(0.031)MAS(0.007)PKLVT(0.998)S(0.998)DT(0.998)AAGK 44.238 0.04682 0.0 492.82 271.67 691.1 595.35 394.75 512.71 386.31 494.03 284.83 445.96 True False 504.3017471392092 239.8627501040434 597.2524159405664 491.38329860359926 359.04493219877315 507.55260290343364 357.1703256800347 480.9267195643996 483.3357068398842 503.20331001825735 1.0021828892995797 0.4766716460894119 1.1869008093744389 0.976510465691831 0.713518621699341 1.0086432119952042 0.7097932755392165 0.9557304373593061 0.9605177414718271 1.0 8.974997601918833 -14.522878745280327 0.11282532696434881 1.4044892350487812 0.8145912304873836 0.03536528337727629 0.1907842249323303 649.4339177897318 4.819857114669756 59.5502437995765 2.1755964395719687 3.0000000000000748e-15 14.522878745280327 -0.5898980045613976 AFS(ph)SPQEEEEAGFTGR ddPTM_A459_Selumetinib_30min_R1 1 AFSSPQEEEEAGFTGR 16 0 A0A024RAC6;Q14241 A0A024RAC6 TCEB3 Transcription elongation factor B polypeptide 3 1 AFS(0.5)S(0.5)PQEEEEAGFTGR 271.41 1.459e-50 10743000.0 1378.0 4275.1 2802.8 4201.3 3152.7 3455.8 3380.5 2666.2 1209.7 2033.0 True False 1410.1047188787595 3774.5693045599323 2422.195154678365 3467.6218231683943 2867.5388416543938 3421.0377896153464 3125.5061633438368 2595.4837149618475 2052.772547007719 2293.955353096951 0.6147045176685979 1.6454414858005324 1.0559033554895842 1.5116343997222685 1.2500412607346856 1.4913271023329984 1.3624965102848456 1.1314447386510023 0.8948615953821317 1.0 11.1636215973356 -8.012204189210482 3.8639328010690344 0.955552824335366 1.2971061169334266 0.18470124708627456 0.27242449849650446 0.335178410307941 10.965404471915054 0.1748586218272255 0.0670779720143104 9.722899814902959e-09 8.012204189210482 0.34155329259806055 AFS(ph)SPQEEEEAGFTGR ddPTM_A459_Selumetinib_30min_R2 1 AFSSPQEEEEAGFTGR 16 0 A0A024RAC6;Q14241 A0A024RAC6 TCEB3 Transcription elongation factor B polypeptide 3 1 AFS(0.922)S(0.078)PQEEEEAGFTGR 276.14 1.495e-51 11186000.0 15070.0 15014.0 17636.0 13611.0 19178.0 10685.0 9841.7 10784.0 10313.0 16397.0 True False 14232.469729989816 16165.525522380985 16501.31896062495 11757.158319715356 16768.68818650468 12156.761761227295 10299.358550958583 10815.379654612696 12375.88816929601 15923.576005477647 0.8937985867680666 1.0151944209529384 1.0362822367883044 0.7383491192977595 1.053073014550018 0.7634442010416138 0.6467993462910369 0.6792054530271496 0.7772053315812197 1.0 13.958876742191674 -6.857279783697049 7.683752736485322 0.7433954786984684 0.9440660669801693 0.3212828545565638 0.12283198032239338 0.2467743960893551 17.30583798207275 0.04195263249020742 0.03703130880213808 1.3890574762810224e-07 6.857279783697049 0.2006705882817008 AFSASSASGAAGCCCASSGAGAAASSSSSSGS(ph)PHLYR ddPTM_A459_Selumetinib_30min_R2 2 AFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYR 37 0 Q15464;Q15464-2 Q15464 SHB SH2 domain-containing adapter protein B 1 AFSASSASGAAGCCCASS(0.001)GAGAAAS(0.002)S(0.004)S(0.003)S(0.009)S(0.032)S(0.086)GS(0.864)PHLYR;AFSASSASGAAGCCCAS(0.001)S(0.002)GAGAAAS(0.002)S(0.005)S(0.024)S(0.024)S(0.071)S(0.214)GS(0.654)PHLY(0.003)R 135.65 9.8916e-35 10076500.0 16423.6 13615.6 25988.3 36346.8 40561.0 26110.9 23055.1 24170.5 22182.8 33062.3 True False 15510.842060879928 14659.872738945687 24316.24107192161 31396.303138272742 35465.36456005927 29707.439463849325 24127.207832813965 24240.832153358308 26619.979839218424 32107.70549282816 0.4830878389720049 0.456584253341312 0.75733350292979 0.9778432515299381 1.1045748681101208 0.9252433024367007 0.7514460302435256 0.7549848792145218 0.8290838423556762 1.0 14.970631949241097 -5.394230884160262 3.2730771418406617 0.8976722448296894 0.46623461660136284 0.7302035389690529 0.10457452385880521 0.14399465046104026 2.8458300777685865 0.03278808857566011 0.07776550936623902 4.034308598267644e-06 5.394230884160262 -0.4314376282283266 AFSS(ph)PQEEEEAGFTGR ddPTM_A459_Selumetinib_30min_R1 1 AFSSPQEEEEAGFTGR 16 0 A0A024RAC6;Q14241 A0A024RAC6 TCEB3 Transcription elongation factor B polypeptide 3 1 AFS(0.002)S(0.998)PQEEEEAGFTGR 291.13 1.1128999999999996e-74 10944000.0 1813.4 4077.4 2667.6 3643.7 2857.9 2908.8 2851.3 2012.1 864.52 1863.3 True False 1855.6486917378402 3600.016112468167 2305.3545720779257 3007.396195720055 2599.403449603225 2879.5401129790844 2636.224145405201 1958.7325717780882 1467.0272979574381 2102.472705078972 0.8826029880222104 1.7122772170937388 1.0964967899506373 1.4304091503566476 1.2363553844593609 1.3695969065486273 1.2538684278929464 0.9316328183696992 0.6977628267960484 1.0 11.037871355771369 -7.791076838833927 3.584720584743178 0.8394850944407442 1.3035197967422598 0.43289343105267364 0.2142052968388638 0.1898268550787762 5.070121287582896 0.11443444765660754 0.05349653514929307 1.617793779377595e-08 7.791076838833927 0.46403470230151567 AFSS(ph)PQEEEEAGFTGR ddPTM_A459_Selumetinib_30min_R2 1 AFSSPQEEEEAGFTGR 16 0 A0A024RAC6;Q14241 A0A024RAC6 TCEB3 Transcription elongation factor B polypeptide 3 1 AFS(0.001)S(0.999)PQEEEEAGFTGR 202.32 4.9111e-07 9747600.0 25308.0 32992.0 34370.0 29014.0 34082.0 24645.0 24671.0 23486.0 18882.0 31991.0 True False 23901.482675951043 35522.38031399986 32158.671619226552 25062.243148058304 29800.31446305417 28039.62504496461 25818.250384659066 23554.340371683404 22658.927607160607 31067.336707399834 0.7693444372480768 1.1433995983807295 1.0351280485387335 0.8067071659248088 0.959216901780838 0.9025435720174216 0.8310416379692275 0.7581705697377358 0.7293488920717026 1.0 14.923110949180552 AFSSGVDLSMAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AFSSGVDLSMASPK 14 0 J3QS68;Q8IUD6-3;Q8IUD6 J3QS68 RNF135 E3 ubiquitin-protein ligase RNF135 1 AFSSGVDLS(0.002)MAS(0.998)PK 123.72 0.0015869000000000002 1559300.0 8736.4 8320.2 6969.1 10181.0 10389.0 7971.4 7708.9 6608.2 5091.4 7680.7 True False 8250.865862580153 8958.332586340368 6520.715693382364 8794.33023679539 9083.840941161596 9069.387992835502 8067.379124895557 6627.428767953598 6109.822265602031 7458.938234144792 1.1061716297381512 1.2010198107462262 0.8742150006729477 1.1790324521709499 1.2178463818856262 1.2159087135644255 1.0815720510950881 0.8885217386055309 0.8191276122428645 1.0 12.864754564827123 -7.70343373469512 4.29673487760916 0.8883093061625899 1.1307735166263757 0.49768546124278445 0.10304535095137518 0.17412268329371902 6.4700642924364535 0.05513437130662638 0.02927461748411882 1.9795490407639923e-08 7.70343373469512 0.24246421046378586 AFVDFLSDEIKEER ddPTM_A459_Selumetinib_30min_R1 1 AFVDFLSDEIKEER 14 1 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 183.06 0.00021605 17883000.0 3188.0 4375.7 2934.9 3455.0 3138.7 3141.9 3323.6 4007.9 2136.9 3221.6 False True 3262.2741972318477 3863.391009792258 2536.3567002517248 2851.649108382356 2854.8051391824906 3110.295338616951 3072.8981761542877 3901.597472506038 3626.163226999085 3635.1237410413883 0.8974314025132122 1.0627949101632166 0.6977360004600863 0.7844709868295755 0.7853391913323555 0.8556229609190458 0.8453352334228835 1.073305271140044 0.9975350181505138 1.0 11.82778875954926 -7.752064756854218 24.550187039599777 1.026565108197344 0.8450828922953134 0.4411939789511934 0.0910699582729849 147.49869776518725 386271.69177931483 0.04649232166234247 0.026361553079062666 1.7698450402915714e-08 7.752064756854218 -0.1814822159020305 AFVEDS(ph)EDEDGAGEGGSSLLQK ddPTM_A459_Selumetinib_30min_R1 4 AFVEDSEDEDGAGEGGSSLLQK 22 0 A0A494C108;Q8N9T8;H0YFD2;F8WFC1 A0A494C108 KRI1 Protein KRI1 homolog 1 AFVEDS(1)EDEDGAGEGGSSLLQK;AFVEDS(1)EDEDGAGEGGSSLLQK;AFVEDS(1)EDEDGAGEGGSSLLQK;AFVEDS(1)EDEDGAGEGGSSLLQK 183.99 5.5152e-17 20640700.0 10508.460000000001 11889.67 13327.27 13645.619999999999 12255.88 10573.779999999999 11027.58 11058.86 6458.21 9700.86 True False 10753.286672096288 10497.621909042371 11517.499935453949 11262.668627011415 11147.337817951351 10467.417373424085 10195.760762244412 10765.543108560116 10959.11068100414 10946.059875378303 0.982388804238534 0.9590320196087513 1.052205091748221 1.0289244490928906 1.0183881638566399 0.9562726216187744 0.9314548685393556 0.9835085164092482 1.001192283412883 1.0 13.418124032827723 -6.756729399568632 24.999980165002373 0.970765514759117 1.0090542888995009 0.2301288876975246 0.03042270868301942 179.33000203927844 951859.4635639191 0.011092509934275673 0.010750069735360593 1.7509373237497844e-07 6.756729399568632 0.0382887741403839 AFVEDS(ph)EDEDGAGEGGSSLLQK ddPTM_A459_Selumetinib_30min_R2 1 AFVEDSEDEDGAGEGGSSLLQK 22 0 A0A494C108;Q8N9T8;H0YFD2;F8WFC1 A0A494C108 KRI1 Protein KRI1 homolog 1 AFVEDS(1)EDEDGAGEGGSSLLQK 96.133 0.00077558 0.0 16072.0 14044.0 16946.0 18522.0 16929.0 11708.0 13538.0 15901.0 14903.0 15204.0 True False 15178.782581313608 15121.129641422582 15855.71280940974 15999.271647767833 14802.227672819783 13320.670725357913 14167.543825038081 15947.26927744774 17884.016424611513 14765.021015263896 1.028023093609008 1.0241183961601237 1.0738699791228405 1.0835928801745682 1.0025199190382068 0.9021775662619896 0.9595342810817438 1.0800708824566962 1.2112421923492853 1.0 13.849895789431098 -7.973730320082213 9.501117828142808 1.1189352127299297 1.0123213029297284 0.25174556504153955 0.06850902209876954 0.3663408976637193 125.89877150068834 0.039737165360293834 0.018867763560105697 1.0623550334229424e-08 7.973730320082213 -0.10661390980020125 AFVHWYVGEGMEEGEFSEAR ddPTM_A459_Selumetinib_30min_R1 1 AFVHWYVGEGMEEGEFSEAR 20 0 Q9BQE3;F5H5D3;Q9NY65;Q9NY65-2;C9J2C0;P68363;P68363-2;P68366-2;P68366 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA8;TUBA1B;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 195.92 2.4143000000000002e-15 18566000.0 2847.9 4217.7 2839.2 3345.2 3309.4 2865.0 3178.7 2764.9 1530.0 2558.2 False True 2914.250528951248 3723.8897232444638 2453.6522346092524 2761.023617181088 3010.065354322026 2836.1807012118675 2938.9280998139466 2691.5658703390664 2596.2982532213023 2886.569888978172 1.0095894577431743 1.2900743326754156 0.850023498124215 0.9565067617879411 1.0427827733585797 0.982543576042033 1.018138556435337 0.9324443799598644 0.8994406347598866 1.0 11.495140440637126 -5.266464795828391 24.998826631679865 0.9635020230371962 1.1498318934933958 0.45678613244659594 0.08264135136674829 327.5204140445722 1629251.590471867 0.020753504243687385 0.04538787762209111 5.414211340263317e-06 5.266464795828391 0.18632987045619953 AFYPEEISSMVLTK ddPTM_A459_Selumetinib_30min_R1 1 AFYPEEISSMVLTK 14 0 A0A0G2JIW1;P0DMV9;P0DMV8;Q53FA3;P34931 A0A0G2JIW1;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 204.49 0.00032137 5931800.0 1856.5 1597.5 1930.3 1920.2 1967.8 2055.0 1967.9 2005.9 1151.0 1259.0 False True 1899.7528378798374 1410.4639573423988 1668.175862378925 1584.8731166181774 1789.8128374433074 2034.3285657907109 1819.4597186346202 1952.6970159185262 1953.1629342860895 1420.6049136985062 1.3372844339485515 0.9928615223991407 1.1742714996218582 1.115632574078604 1.2598948660423668 1.4320157182156945 1.2807640612038336 1.3745531900454524 1.3748811618573689 1.0 10.472289665209885 -6.421530730253434 4.594453284258453 1.318016459242245 1.146009227198081 0.17367206852701245 0.13569160267205096 0.3038174164397183 10.530967289305682 0.040375401323181424 0.045566825509291344 3.78851725621848e-07 6.421530730253434 -0.1720072320441639 AGAAAGDS(ph)DEESRADDK ddPTM_A459_Selumetinib_30min_R1 4 AGAAAGDSDEESRADDK 17 1 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 AGAAAGDS(1)DEESRADDK;AGAAAGDS(0.73)DEES(0.27)RADDK;AGAAAGDS(0.812)DEES(0.188)RADDK;AGAAAGDS(0.998)DEES(0.002)RADDK 242.1 4.5401e-22 26693200.0 4230.75 5844.07 3280.4500000000003 3866.5200000000004 3627.9800000000005 3502.99 3936.14 3744.75 2088.73 3793.84 True False 4329.31824339355 5159.8435675655655 2834.9829082220094 3191.30486556948 3299.8298495718936 3467.753101060437 3639.233790795507 3645.4270653377043 3544.4222551966864 4280.81631913101 1.0113300643257654 1.2053410337897879 0.6622528734887417 0.7454897915865971 0.7708412610055054 0.8100681838561993 0.8501261253681304 0.8515728761933222 0.8279781216859572 1.0 12.063670218500139 -5.255948840294654 24.989493732547675 0.8065387824300955 1.1083355609294578 0.6136264421612196 0.09298771790390178 268.41768083068 1221659.6585459723 0.023194647618763234 0.0578246683707739 5.5469105147947016e-06 5.255948840294654 0.3017967784993624 AGAAAGDS(ph)DEESRADDK ddPTM_A459_Selumetinib_30min_R2 2 AGAAAGDSDEESRADDK 17 1 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 AGAAAGDS(1)DEESRADDK;AGAAAGDS(1)DEESRADDK 84.208 0.006832600000000001 39915300.0 102166.0 68748.0 75312.0 86846.0 57941.0 71319.0 106558.0 99829.0 77584.0 81420.0 True False 96488.02272290246 74020.75054033898 70466.50791350551 75017.42498229361 50661.93358088789 81142.54488057733 111513.15814067132 100119.48586241947 93102.9678780822 79069.1930454347 1.2202985639104544 0.9361515868488149 0.891200544730665 0.9487566787128728 0.6407291086400306 1.0262219931086338 1.4103237157940094 1.2662262254894756 1.177487265167654 1.0 16.27082808059651 -7.011397951337528 24.61094080673523 1.2332060081764784 0.9177234716600168 0.40964286830417507 0.16131779886079675 413.81216861439907 893520.5658997657 0.05957826407733598 0.04901353766391224 9.740966475088843e-08 7.011397951337528 -0.31548253651646163 AGAAAGDSDEES(ph)RADDKGVMDYYLK ddPTM_A459_Selumetinib_30min_R1 1 AGAAAGDSDEESRADDKGVMDYYLK 25 2 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 AGAAAGDS(0.34)DEES(0.64)RADDKGVMDY(0.015)Y(0.005)LK 69.72 0.00146 16763000.0 1792.6 1627.4 2465.5 2360.4 1891.1 1983.5 1588.9 1725.5 818.47 1520.4 True False 1834.3640922075942 1436.8632514422657 2130.6986420220887 1948.2004501955769 1720.0503389008218 1963.5477908739058 1469.0479937692714 1679.734134786089 1388.8838113163642 1715.5581499501266 1.0692520636860496 0.8375485561267842 1.241985672175572 1.1356073533573978 1.002618499962141 1.1445533285659764 0.856309064086215 0.9791181574550073 0.8095813081921711 1.0 10.744462312465473 -7.266408122577862 24.981303835076407 0.9095119764842983 1.0687480233308686 0.33309982708199315 0.11131229132663856 521.4443443007075 2621649.2506776815 0.045717891260026636 0.031895252524867475 5.414917913774986e-08 7.266408122577862 0.15923604684657033 AGAAAGDSDEES(ph)RADDKGVMDYYLK ddPTM_A459_Selumetinib_30min_R2 1 AGAAAGDSDEESRADDKGVMDYYLK 25 2 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 AGAAAGDS(0.02)DEES(0.98)RADDKGVMDYYLK 75.057 0.00035526 5657200.0 12740.0 12122.0 12344.0 15323.0 12453.0 10200.0 8920.6 12448.0 6892.9 14235.0 True False 12031.961802260801 13051.718421626634 11549.800479130996 13235.980966350631 10888.54280876748 11604.95741361895 9335.425575833558 12484.22161912267 8271.672603717685 13823.998563028255 0.8703676976963679 0.944134821927206 0.8354891261360867 0.957464000448448 0.7876550882961217 0.8394790668349716 0.675305739744562 0.9030832549788622 0.5983560086471617 1.0 13.754887352198761 -6.280825087681539 24.156965630083146 0.7914752623980007 0.9001422042807011 0.16785313246474942 0.10924099827526935 846.8959205129088 1055333.0923129187 0.031201231311650503 0.035440138613804906 5.238113593936331e-07 6.280825087681539 0.10866694188270043 AGAAS(ph)PLNSPLSSAVPSLGK ddPTM_A459_Selumetinib_30min_R2 2 AGAASPLNSPLSSAVPSLGK 20 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 AGAAS(0.998)PLNS(0.002)PLSSAVPSLGK;AGAAS(0.996)PLNS(0.004)PLSSAVPSLGK 229.51 6.7769e-24 58164000.0 112977.0 91677.0 115212.0 105740.0 123895.0 106783.0 108609.0 111210.0 107950.0 101859.0 True False 106698.19062276436 98708.3311119838 107799.38535334093 91338.02958832578 108330.20246464682 121491.3889704383 113659.53370465066 111533.6026881933 129543.0163750124 98918.06600853505 1.0786522111497612 0.9978797109060629 1.0897846035934382 0.9233705557935672 1.0951508337748905 1.2282022270831248 1.1490270512854917 1.1275352136238666 1.3095991622383205 1.0 16.593946412775367 -6.523888902121285 13.489973443091664 1.1690679219624758 1.023449805754808 0.377276010565158 0.08489627040710693 0.12640316052915934 1409.5782473275308 0.025934703141143794 0.026603201310592572 2.9930301926802804e-07 6.523888902121285 -0.14561811620766774 AGADGGT(ph)PTDR ddPTM_A459_Selumetinib_30min_R2 1 AGADGGTPTDR 11 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 AGADGGT(0.937)PT(0.063)DR 113.61 0.016368999999999998 2692100.0 16436.0 16086.0 16037.0 16692.0 15752.0 14698.0 33289.0 54527.0 27405.0 38516.0 True False 15522.552918521062 17319.7444753577 15005.196879765377 14418.52080469391 13773.092935333278 16722.51608484032 34837.0044609021 54685.664542569204 32886.76575967779 37403.94300341385 0.4149977695427544 0.46304595410641414 0.40116617861373216 0.3854813061654472 0.3682256957261487 0.4470789639293927 0.9313725148635408 1.4620294052308351 0.8792325920472135 1.0 15.190902741951838 -7.340940116501633 3.4782119445755457 1.1373761007195182 0.4079192424715099 0.8373602545259373 0.1425756457778071 0.08428726247922384 1.9698253688900296 0.05992390073751925 0.039115953796691354 4.560998017808845e-08 7.340940116501633 -0.7294568582480083 down AGAES(ph)PTMSVDGR ddPTM_A459_Selumetinib_30min_R1 2 AGAESPTMSVDGR 13 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 AGAES(0.964)PT(0.036)MSVDGR;AGAES(0.77)PT(0.23)MSVDGR 226.42 7.1131e-13 135616000.0 5959.7 7791.0 6552.3 6926.9 6577.8 5551.8 6474.1 6028.0 3017.5 4889.299999999999 True False 6098.549414442485 6878.826098062366 5662.533649207595 5717.246949017007 5982.839151404912 5495.953932631079 5985.753424672187 5868.11785829646 5120.477110519789 5516.889280815018 1.1054326277038384 1.246866802635225 1.0263997265450036 1.0363171450438082 1.0844588040238972 0.9962052259673324 1.0849870497650995 1.0636642425837401 0.9281457085474323 1.0 12.429639311784905 -5.278323605480913 24.780325947683664 1.0330773552548933 1.1761497123654865 0.5408843999657569 0.05458154200752349 457.8480011205495 671965.6148993194 0.013606329902842869 0.028453266911918067 5.26837153408238e-06 5.278323605480913 0.14307235711059318 AGAES(ph)PTMSVDGR ddPTM_A459_Selumetinib_30min_R2 4 AGAESPTMSVDGR 13 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 AGAES(0.768)PT(0.229)MS(0.004)VDGR;AGAES(0.437)PT(0.437)MS(0.127)VDGR;AGAES(0.959)PT(0.041)MSVDGR;AGAES(0.624)PT(0.358)MS(0.018)VDGR 206.74 1.1918e-05 195856000.0 215911.0 212746.0 262490.0 273375.0 312214.0 219309.0 232103.0 231715.0 240162.0 232283.0 True False 203911.53098021424 229062.93411379188 245601.6791775031 236140.85340182067 272990.88609142636 249516.82406111338 242896.24940336918 232389.25228751692 288201.11068694526 225576.38624628657 0.9039577873083825 1.0154561739618377 1.0887738883685845 1.046833213934014 1.2101926563952141 1.1061300706745447 1.0767804797536416 1.0302020355703012 1.277620922485585 1.0 17.783256526090014 -4.5795022211509195 1.0738294595666718 1.1122719907475311 0.723709974682787 0.3979881820630473 0.07825263618234556 2.5004766706478057 1.7846899460477301 0.02380379050720009 1.2281730020316255 2.6332844759999258e-05 4.5795022211509195 -0.38856201606474416 AGAGMITQHSS(ph)NASPINR ddPTM_A459_Selumetinib_30min_R2 1 AGAGMITQHSSNASPINR 18 0 Q9NWH9;Q9NWH9-3;H7C3F4;H0YKH2 Q9NWH9 SLTM SAFB-like transcription modulator 1 AGAGMITQHS(0.088)S(0.908)NAS(0.004)PINR 113.33 0.0021945 1745500.0 9145.9 11861.0 11636.0 15864.0 19055.0 9790.8 8625.9 12721.0 11368.0 16998.0 True False 8637.60749193854 12770.700560873905 10887.35242831889 13703.295833073587 16661.140546138642 11139.393827966702 9027.021441896588 12758.016003925086 13641.917648458942 16507.223573892108 0.5232622829195707 0.7736431571128713 0.659550794813149 0.8301393490996739 1.0093242192763396 0.6748193467001206 0.5468528006232231 0.7728747324960944 0.8264210869497797 1.0 14.010809866668387 -14.522878745272186 0.22830468901292608 2.388334837342673 0.7092975330744034 0.27697091574918287 0.13397177783129574 245.3669627679619 2.4497873603090827 157.26232450056787 0.25207562248563453 3.000000000056311e-15 14.522878745272186 -1.6790373042682696 AGAGMITQHSSNAS(ph)PINR ddPTM_A459_Selumetinib_30min_R1 2 AGAGMITQHSSNASPINR 18 0 Q9NWH9;Q9NWH9-3;H7C3F4;H0YKH2 Q9NWH9 SLTM SAFB-like transcription modulator 1 AGAGMITQHS(0.13)S(0.008)NAS(0.862)PINR;AGAGMITQHSSNAS(1)PINR 199.01 1.4390999999999999e-21 5152900.0 2310.7200000000003 2913.38 2758.2400000000002 3651.6 3896.91 2323.8599999999997 3724.2200000000003 2282.75 1043.91 1516.08 True False 2364.5552801215736 2572.280115206383 2383.686157927808 3013.916609021423 3544.4351785553417 2300.484078296058 3443.299087013277 2222.204054582988 1771.4390258302287 1710.6836358697624 1.382228268594715 1.5036562350107239 1.3934114455452022 1.7618199799339627 2.0719407751587253 1.3447747029662933 2.0128204974981254 1.2990152053761557 1.0355152692681113 1.0 10.740357265317707 -7.9821883671790275 8.359865953736964 1.0659947874061564 1.6361636772039607 0.5217856221003285 0.24058263608995387 0.13983296835867037 52.99903023555825 0.13762474482633988 0.06415478154181099 1.0418654415622545e-08 7.9821883671790275 0.5701688897978043 AGAGMITQHSSNAS(ph)PINR ddPTM_A459_Selumetinib_30min_R2 2 AGAGMITQHSSNASPINR 18 0 Q9NWH9;Q9NWH9-3;H7C3F4;H0YKH2 Q9NWH9 SLTM SAFB-like transcription modulator 1 AGAGMITQHS(0.008)S(0.005)NAS(0.987)PINR;AGAGMITQHSSNAS(1)PINR 205.98 2.0762e-11 6833400.0 12158.5 13851.3 18830.8 20107.4 26857.0 15933.699999999999 10391.099999999999 14491.6 14315.5 21778.2 True False 11482.77924433186 14913.650171050738 17619.246829424832 17368.73743280028 23482.983555373663 18128.422543272576 10874.30673957403 14533.768156786475 17179.000008489973 21149.406779440953 0.5429362328731655 0.7051569023462205 0.8330846823823096 0.8212399342417581 1.110337694114482 0.85715985948575 0.5141660403517698 0.6871950739968059 0.8122686460023759 1.0 14.368329577251115 -14.522872070049509 0.022548304805235595 1.9513917354266874 2.3391658697038405e-07 0.1283773585510296 0.16422463557920972 8357.373136959552 14.196220697675535 860.3786215789353 434.9851910791065 3.000046111215366e-15 14.522872070049509 -1.9513915015101004 AGAGPGGPPQKPAPS(ph)SQR ddPTM_A459_Selumetinib_30min_R2 1 AGAGPGGPPQKPAPSSQR 18 1 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 AGAGPGGPPQKPAPS(0.5)S(0.5)QR 65.51100000000001 0.018274 3004200.0 6816.3 6882.0 8267.4 10606.0 12271.0 8154.4 7320.2 9307.7 9795.8 10104.0 True False 6437.477333810854 7409.827270882246 7735.484484864524 9161.444503629496 10729.407275868129 9277.594581726891 7660.603804701121 9334.783866027312 11755.23371752059 9812.271266655254 0.6560639385997348 0.7551592357686684 0.7883480057417275 0.9336721595501092 1.0934682688940276 0.9455093861147786 0.7807166757337742 0.9513377292930564 1.1980135279655433 1.0 13.260371403356686 -5.652010839183832 2.1563527180947637 0.9821236334631926 0.7052718924515479 0.5679606498181933 0.10355599878141483 0.2578502659320742 2.4202428803063647 0.032742890581640476 0.07006243661426712 2.2283795323609813e-06 5.652010839183832 -0.2768517410116448 AGALHAQVER ddPTM_A459_Selumetinib_30min_R1 1 AGALHAQVER 10 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 0 140.17 0.0020337 1110400.0 909.23 1326.9 1086.0 1315.7 1071.7 1236.3 1031.6 1134.7 588.91 848.38 False True 930.4132899463971 1171.5459311409252 938.5271649709953 1085.9376937478053 974.7649242240032 1223.8639444705864 953.7855814540756 1104.604069974949 999.3372577153958 957.2778369209999 0.9719365204766358 1.223830622579856 0.9804125080234652 1.1344017921073244 1.0182675150604645 1.278483526169411 0.9963518893551773 1.15390122634387 1.0439364823588482 1.0 9.9027938979491 -8.51913192772247 21.735178636892567 0.9999999905457702 1.0969482102795824 0.0864409769351494 0.09960893454134172 106.06025651925756 615240.9892044124 0.08701316339468224 0.022466702191932073 3.0259940677048773e-09 8.51913192772247 0.09694821973381229 AGAPGALS(ph)PSYDGGLHGLQSK ddPTM_A459_Selumetinib_30min_R1 2 AGAPGALSPSYDGGLHGLQSK 21 0 K7ENH8;A0A0A0MRB7;P15923-2;X6REB3;P15923;P15923-3 K7ENH8 TCF3 Transcription factor E2-alpha 1 AGAPGALS(0.973)PS(0.027)YDGGLHGLQSK;AGAPGALS(0.996)PS(0.004)YDGGLHGLQSK 147.78 1.7859e-06 86486000.0 9614.3 9729.3 10179.900000000001 11079.900000000001 11455.5 9253.7 10074.8 9305.2 5079.3 8044.799999999999 True False 9838.294483828782 8590.189032971142 8797.525494188065 9145.00346048211 10419.352047632796 9160.616179687353 9314.849724731983 9058.3958684506 8619.20112260585 9077.428442987884 1.0838195581071917 0.9463240704041986 0.9691649512240398 1.0074442908494008 1.1478308105729567 1.0091642404257926 1.0261551256763144 0.9979033076760867 0.9495201396232426 1.0 13.148067937024015 -7.949939045901167 3.7956494419708156 0.9739444207724317 1.0248782644240402 0.13072915302286636 0.05452581477734399 0.5021875849333902 14.830864006224822 0.03690808044487808 0.015420231394588056 1.12217594288697e-08 7.949939045901167 0.05093384365160847 AGAPGALS(ph)PSYDGGLHGLQSK ddPTM_A459_Selumetinib_30min_R2 2 AGAPGALSPSYDGGLHGLQSK 21 0 K7ENH8;A0A0A0MRB7;P15923-2;X6REB3;P15923;P15923-3 K7ENH8 TCF3 Transcription factor E2-alpha 1 AGAPGALS(0.963)PS(0.036)Y(0.001)DGGLHGLQSK;AGAPGALS(0.999)PS(0.001)YDGGLHGLQSK 153.57 4.9136e-07 21688000.0 118568.0 112118.0 131347.0 140425.0 159255.0 112487.0 108896.0 109925.0 100006.0 134828.0 True False 111978.46522531056 120717.09008380918 122896.2770198008 121298.87275336352 139247.96314223605 127981.06319468183 113959.87977333047 110244.8635509365 120009.99440110734 130935.16531478579 0.8552207113810811 0.9219608024596678 0.9386040543374393 0.9264040906180145 1.0634878934735768 0.9774384359388718 0.8703535028145842 0.8419805579799207 0.9165604527445865 1.0 16.998493089000135 -10.565594898295481 24.120759823258787 0.9999999999999958 0.9257723777313325 0.12362509039671066 0.060802337027168245 0.0 0.0 0.06501623673681975 0.015768753614474777 2.718974294301402e-11 10.565594898295481 -0.0742276222686633 AGAPVGGS(ph)PGLAK ddPTM_A459_Selumetinib_30min_R1 2 AGAPVGGSPGLAK 13 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 AGAPVGGS(1)PGLAK;AGAPVGGS(1)PGLAK 159.66 0.00036422 17840500.0 4544.4 5898.299999999999 5323.4 6396.9 5138.3 4558.6 4720.8 4731.7 2826.54 4048.5 True False 4650.275678136892 5207.724293954724 4600.511519343088 5279.801499684836 4673.541672240545 4512.744622877632 4364.706255262117 4606.199945272293 4796.431937686361 4568.164410729468 1.017974674294683 1.140003692013162 1.0070809860822096 1.1557818469238785 1.0230677471379035 0.9878682589178119 0.9554617265986578 1.0083262183938673 1.049969201288104 1.0 12.157398859678876 -6.507034725210065 23.70125070508287 0.9988666604065309 1.0805286274892183 0.38146005541722805 0.04818202353464546 355.85799442620765 532332.8730705527 0.014394402723548786 0.015831525192788035 3.1114675412125177e-07 6.507034725210065 0.08166196708268736 AGAPVGGS(ph)PGLAK ddPTM_A459_Selumetinib_30min_R2 4 AGAPVGGSPGLAK 13 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 AGAPVGGS(1)PGLAK;AGAPVGGS(1)PGLAK;AGAPVGGS(1)PGLAK;AGAPVGGS(1)PGLAK 184.11 0.00011058 73192000.0 158618.0 145068.0 160840.0 184976.0 181033.0 143320.0 149545.0 158376.0 120692.0 157433.0 True False 149802.64655816345 156194.24913286013 150491.72950935143 159781.94969860138 158290.01608444564 163061.02907057534 156499.1388177957 158836.84793944188 144833.77241623917 152887.50022994235 0.9798227214969224 1.021628641307788 0.9843298456905392 1.0450949191941121 1.035336543840261 1.0665425808214015 1.0236228506740017 1.0389132381689263 0.9473225227596083 1.0 17.222110934154237 -4.7611673781691435 23.748724751840477 1.021319171806369 0.9798226683491903 0.10510465504247501 0.032280187332517966 7.539505558980164 655889.9248616247 0.00801592282610408 0.04513011544103312 1.7331359141472974e-05 4.7611673781691435 -0.0414965034571787 AGAVTST(ph)PNR ddPTM_A459_Selumetinib_30min_R2 3 AGAVTSTPNR 10 0 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 AGAVT(0.004)S(0.026)T(0.969)PNR;AGAVT(0.003)S(0.02)T(0.977)PNR;AGAVT(0.006)S(0.032)T(0.962)PNR 128.51 0.0072613 55628000.0 272722.0 246300.0 253559.0 281104.0 278325.0 230682.0 203114.0 223553.0 178452.0 229771.0 True False 257565.20303266603 265190.4180206764 237245.28999416577 242817.15026855248 243359.3252429301 262456.3515772984 212559.20346275542 224203.5022188084 214147.3863654812 223136.9142132466 1.154292215345943 1.1884650236188186 1.0632274396670922 1.0881980291100464 1.090627815218227 1.1762121588114962 0.9525954242587477 1.0047799711191778 0.9597129507707794 1.0 17.767569677158264 -7.2677466097200405 24.992958621677158 0.9796704113382363 1.1233448349577415 0.764362372974586 0.040110197578282464 269.03016840335965 1066051.774385803 0.017401150362386122 0.012052950221099477 5.39825493281612e-08 7.2677466097200405 0.14367442361950522 AGAVTSTPNRNS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 AGAVTSTPNRNSSK 14 1 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 AGAVTSTPNRNS(0.772)S(0.227)K 67.415 0.036481 2566800.0 8833.4 6618.9 9128.1 8655.3 9274.1 5386.7 6922.0 9320.1 6818.6 9248.2 True False 8342.47499090192 7126.548346882083 8540.807983923829 7476.433208774692 8109.004646494062 6128.669029405998 7243.886715682789 9347.219947974383 8182.510527602233 8981.180436290686 0.9288840203223265 0.7934979591419294 0.9509671968522732 0.8324555176025982 0.9028885127090442 0.6823901460259714 0.8065628752332009 1.0407562807896191 0.9110729469968971 1.0 13.132689361884713 -7.755279780074691 24.999966668958603 0.9819359676591568 0.8405822230685921 0.4070077475441386 0.07819007472055728 145.12767025180628 589036.323132443 0.038197246629974764 0.021340205035748874 1.7567914936321795e-08 7.755279780074691 -0.1413537445905647 AGCECLNESDEHGFDNCLR ddPTM_A459_Selumetinib_30min_R2 1 AGCECLNESDEHGFDNCLR 19 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 94.387 0.0025595 9178400.0 3232.1 3898.7 7261.5 3164.3 6770.6 2256.4 2985.6 8043.4 3515.7 2164.9 False True 3052.4728211214388 4197.717753703659 6794.30299572341 2733.316881278034 5920.016698068028 2567.1986184401776 3124.4363158541646 8066.804962343446 4218.938236865508 2102.393711914286 1.451903515418185 1.9966373234067198 3.231698685750451 1.3000975344381502 2.815845892479241 1.221083664725516 1.4861328295209184 3.8369620859445983 2.006730810198272 1.0 11.03781715045987 -4.817469938077573 4.648555103739609 2.1815469540064276 1.431806714798174 0.04162581065495896 0.8868246786571121 0.5689277333512073 23.039083196541448 0.21580192804999135 1.1802716617746634 1.5224045102781436e-05 4.817469938077573 -0.7497402392082537 AGCFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AGCFSPK 7 0 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 AGCFS(1)PK;AGCFS(1)PK 94.309 0.024564 29010000.0 10092.3 14013.8 15086.9 16233.900000000001 11836.3 12890.8 11949.6 11786.0 6240.200000000001 11168.2 True False 10327.430953802688 12373.057781161127 13038.18184640967 13398.954113044387 10765.708754868494 12761.130255909928 11048.23205132184 11473.396993676526 10589.163633824557 12601.747257480267 0.8195237329230224 0.9818525580900386 1.0346328632063575 1.0632616127966625 0.8543028625239314 1.012647690449041 0.8767222374471701 0.9104608082713321 0.8402932877057139 1.0 13.621336159698425 -7.27538709218658 24.764318340638546 0.8994074832269177 0.965123358744844 0.09403765912173245 0.080456007749902 1538.4941501840428 2731601.725271083 0.03356292473736727 0.022758490785272232 5.3041147099928e-08 7.27538709218658 0.06571587551792635 AGCFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AGCFSPK 7 0 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 AGCFS(1)PK;AGCFS(1)PK 105.1 0.017692 23296800.0 154152.0 153018.0 157141.0 127210.0 121044.0 115854.0 123981.0 138127.0 92733.0 140650.0 True False 145584.84895934878 164753.98856958104 147030.71914218474 109883.77855051022 105837.37057291015 131811.83688209899 129746.36216369073 138528.9267018443 111282.1911765081 136589.0690474127 1.0658601744244518 1.206201855819017 1.0764457226891821 0.8044844240966856 0.7748597403220602 0.9650247842039582 0.9499029685798157 1.0142021441976314 0.8147225246690855 1.0 17.059482506658554 -5.605865963641842 5.889472767761608 0.9037904345960747 1.1373801332758973 0.5751817141367791 0.08475652890998897 0.1410207257488465 7.7410690555633845 0.023994357300496674 0.04218323028677985 2.4781867827032757e-06 5.605865963641842 0.2335896986798226 AGDGS(ph)SVKEVETYHR ddPTM_A459_Selumetinib_30min_R2 1 AGDGSSVKEVETYHR 15 1 Q6PL18 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 AGDGS(0.5)S(0.5)VKEVETYHR 65.495 0.028202 3682000.0 46688.0 48476.0 44467.0 47488.0 44904.0 30863.0 31512.0 28497.0 24035.0 38169.0 True False 44093.267866872215 52193.95332509266 41606.041632008935 41020.05247863072 39262.75807314664 35114.09810358055 32977.37043984339 28579.921552067688 28842.67159401043 37066.961795028124 1.1895571077742484 1.4080990401563895 1.1224562148384563 1.1066472808174106 1.0592386365589057 0.947315247949199 0.8896701764282909 0.7710349100125379 0.7781234338412695 1.0 15.17784624860788 -6.294644173794858 0.7915444208766732 0.8313046529476148 1.300364405651487 0.7683992788596796 0.08894019676864598 0.29966456487387144 0.4070657254489808 0.049275724118278325 0.08133780863843867 5.074062661746712e-07 6.294644173794858 0.4690597527038721 AGDLLEDS(ph)PK ddPTM_A459_Selumetinib_30min_R1 10 AGDLLEDSPK 10 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK 156.36 0.0005099999999999999 4762166900.0 91402.8 127540.70000000001 84936.59999999999 83342.1 62011.7 80993.90000000001 86823.59999999999 83481.2 69436.4 104968.6 True False 93532.30740111126 112608.17555193733 73402.67624334748 68787.96675997482 56402.75268405485 80179.1749025772 80274.42594991864 81267.00739084589 117828.49936599696 118442.34229074896 0.7896864043055715 0.9507425585649929 0.6197334063451788 0.5807717529860735 0.47620429985755386 0.6769468869988707 0.6777510845983037 0.6861313768293598 0.9948173692542727 1.0 16.853825400779492 -8.260442757201895 6.270182520756317 1.0009365408472692 0.6780234846763038 0.5307782651578437 0.11850513012267236 0.12089452256848228 24.764474798968052 0.10741069543805676 0.03384583817652613 5.489809100434368e-09 8.260442757201895 -0.32291305617096544 AGDLLEDS(ph)PK ddPTM_A459_Selumetinib_30min_R2 10 AGDLLEDSPK 10 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK;AGDLLEDS(1)PK 174.9 6.9555e-05 5618889000.0 1458866.0 1230099.0 1141662.0 1015359.0 1008400.0 812376.0 1327295.0 1126179.0 807039.0 967267.0 True False 1377788.068023312 1324443.6379083071 1068208.7098676008 877065.3526080285 881715.7767896197 924273.4199849117 1389016.8474851456 1129455.994441029 968469.3505537162 939339.4884485155 1.4667626400961502 1.4099733421149567 1.1371913168815413 0.9337043352203326 0.9386550737326379 0.983960997436094 1.4787165498379626 1.2023938185613001 1.0310110055665964 1.0 19.841287133683913 -5.26027210581407 3.879016577609023 1.092239738569887 1.451416050239567 0.4586610260453461 0.153258077162662 0.21351188233988552 7.456163714430307 0.04502573114156993 0.11921729678087031 5.4919666862808e-06 5.26027210581407 0.35917631166968 AGDLLEDS(ph)PKRPK ddPTM_A459_Selumetinib_30min_R1 2 AGDLLEDSPKRPK 13 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 AGDLLEDS(1)PKRPK;AGDLLEDS(1)PKRPK 191.01 0.0037119 564330000.0 9722.2 9291.3 15773.4 17314.4 9554.2 10767.2 8976.0 8797.099999999999 5922.9 7951.8 True False 9948.708343891927 8203.470276591812 13631.458917084241 14290.765071541378 8690.02429693101 10658.891743835402 8298.933093380943 8563.772330992004 10050.728708499642 8972.490987091167 1.1088011521221093 0.9142912808042098 1.519250221225743 1.592731058978123 0.9685185874729163 1.187952348926344 0.9249307806851765 0.9544475824286487 1.1201715023129863 1.0 13.131292853510304 AGDLLEDS(ph)PKRPK ddPTM_A459_Selumetinib_30min_R2 3 AGDLLEDSPKRPK 13 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 AGDLLEDS(1)PKRPK;AGDLLEDS(1)PKRPK;AGDLLEDS(1)PKRPK 187.08 0.0045105 390287000.0 920442.0 1159361.0 1100301.0 947145.0 866317.0 599579.0 532713.0 606651.0 353636.0 949790.0 True False 869287.5184612653 1248280.2607668298 1029508.8315771461 818142.2170837414 757482.5134877557 682165.564813749 557485.2100507844 608416.2539735201 424373.0814154132 922367.0948492181 0.9424528729565858 1.3533443113242125 1.116159539218431 0.8870028231194494 0.8212375720228652 0.7395814189634167 0.6044070882015994 0.6596248471688808 0.4600913061461571 1.0 19.814981520660865 -6.110763329427222 1.3085079700677638 0.66424960858747 1.1726220573750716 0.5810384026701771 0.16084636440020467 0.2804124025294926 0.9736655387186742 0.05834482742404346 0.0962113037044466 7.748839589787408e-07 6.110763329427222 0.5083724487876017 AGDNIPEEQPVASTPTTVS(ph)DGENKK ddPTM_A459_Selumetinib_30min_R2 1 AGDNIPEEQPVASTPTTVSDGENKK 25 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 AGDNIPEEQPVAS(0.001)T(0.001)PT(0.069)T(0.167)VS(0.763)DGENKK 69.095 0.00073281 8276100.0 59405.0 15024.0 38700.0 34446.0 14800.0 25269.0 81683.0 49176.0 41750.0 28540.0 True False 56103.50791705672 16176.292490225918 36210.0841333741 29754.395377335637 12940.691686321268 28749.575380856582 85481.42135179389 49319.09401847492 50101.16659246664 27715.976044174677 2.0242299180673635 0.5836450596018551 1.306469744224819 1.073546727342817 0.46690369719240443 1.037292546906323 3.084193073898991 1.7794464080885497 1.8076638005680794 1.0 14.75843019393226 -7.108885389461938 24.48290186070276 1.9939387757682254 1.0410355530859219 0.3000054863004954 0.6192192303069063 25.47281641282997 5708.345936197205 0.2269898670974701 0.17582563911043267 7.782419023824045e-08 7.108885389461938 -0.9529032226823035 AGDNIPEEQPVASTPTTVS(ph)DGENKKDK ddPTM_A459_Selumetinib_30min_R2 1 AGDNIPEEQPVASTPTTVSDGENKKDK 27 2 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 AGDNIPEEQPVAS(0.008)T(0.008)PT(0.183)T(0.183)VS(0.618)DGENKKDK 75.26100000000002 5.6793e-05 13137000.0 119030.0 38191.0 74269.0 80667.0 29375.0 36335.0 123820.0 62768.0 46347.0 54668.0 True False 112414.78911484321 41120.12689658004 69490.61339797324 69680.01544166318 25684.64988416805 41339.81643371025 129577.87534467531 62950.64448819825 55617.695043378466 53089.592795477954 2.1174543483109636 0.7745421415265132 1.308930992665144 1.3124985853648958 0.4837982084947506 0.7786802319800704 2.440739672723812 1.1857435925475819 1.0476195449010084 1.0 15.69614145538296 AGDPGEMPQS(ph)PTGLGQPK ddPTM_A459_Selumetinib_30min_R1 5 AGDPGEMPQSPTGLGQPK 18 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9;H0YHL2 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 AGDPGEMPQS(0.657)PT(0.343)GLGQPK;AGDPGEMPQS(0.997)PT(0.003)GLGQPK;AGDPGEMPQS(0.897)PT(0.103)GLGQPK;AGDPGEMPQS(0.985)PT(0.015)GLGQPK;AGDPGEMPQS(0.99)PT(0.01)GLGQPK 261.66 1.02e-42 93840300.0 21569.0 26351.000000000004 25363.2 29289.800000000003 25280.399999999998 23634.6 24323.2 22796.199999999997 12931.5 19797.100000000002 True False 22071.515734031895 23265.81266975245 21919.016750085022 24174.886267640406 22993.792283617116 23396.857382499824 22488.481441279335 22191.570723506607 21943.811020608675 22338.250625083954 0.9880592757450515 1.0415234863390297 0.981232466139127 1.0822193140090417 1.029346150221676 1.04738986840031 1.0067252722120812 0.9934336889652121 0.982342412971571 1.0 14.447228588050303 -7.50826646497814 4.177237746945264 0.9917655212402552 1.0292862044236353 0.26598509101527046 0.027318634760535764 0.28058219814420077 11.540865405012047 0.012651447816932393 0.0076137179108334094 3.102655344109304e-08 7.50826646497814 0.03752068318338009 AGDPGEMPQS(ph)PTGLGQPK ddPTM_A459_Selumetinib_30min_R2 6 AGDPGEMPQSPTGLGQPK 18 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9;H0YHL2 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 AGDPGEMPQS(0.5)PT(0.5)GLGQPK;AGDPGEMPQS(0.807)PT(0.193)GLGQPK;AGDPGEMPQS(0.906)PT(0.094)GLGQPK;AGDPGEMPQS(0.993)PT(0.007)GLGQPK;AGDPGEMPQS(0.997)PT(0.003)GLGQPK;AGDPGEMPQS(0.989)PT(0.011)GLGQPK 194.92 2.7837e-10 145434000.0 478782.0 432302.0 470033.0 530452.0 521450.0 361611.0 422163.0 446718.0 359993.0 434893.0 True False 452173.2131562033 465458.17332998104 439791.58851323614 458203.5225192599 455940.78917785356 411419.63287217217 441794.416000115 448017.87542185385 432001.65904483385 422336.5091022857 1.0706467553973444 1.1021026202999933 1.0413297904271945 1.0849252021645317 1.0795675470893975 0.9741512372365857 1.0460720455808776 1.06080782922167 1.022884950114998 1.0 18.688033441500586 -6.688090677208622 24.999999635914754 1.0261618690582321 1.0757821988703582 0.5138118478645382 0.026459595994922872 38.15764756444171 13004.48206489262 0.008752282708978616 0.008752280181156097 2.0507339573009658e-07 6.688090677208622 0.04962032981212605 AGDPGEMPQSPT(ph)GLGQPK ddPTM_A459_Selumetinib_30min_R1 1 AGDPGEMPQSPTGLGQPK 18 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9;H0YHL2 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 AGDPGEMPQS(0.098)PT(0.902)GLGQPK 114.24 0.011291 5592100.0 2509.9 3201.4 3260.4 3616.8 2941.6 2655.2 3027.1 3020.7 1580.5 2532.2 True False 2568.3757865847583 2826.5785997095168 2817.6555880952415 2985.193775744518 2675.5327993816613 2628.4910987287076 2798.763409867809 2940.5812233835645 2681.993064847232 2857.232535716724 0.898903310976225 0.9892714591395628 0.9861485030963519 1.0447850283196132 0.9364070883052981 0.919943009843041 0.9795364482526276 1.029171125074681 0.9386681102504195 1.0 11.480402739373034 -1.5229022821202591 0.004189075920164475 1.8991780692281381 1.9484610017049466e-05 0.05139141802636593 0.04392098260402703 322715.83582898125 105.14745202289728 22402.490722756847 25351.383733307095 0.029998374176754425 1.5229022821202591 -1.8991585846181211 AGDPGEMPQSPT(ph)GLGQPK ddPTM_A459_Selumetinib_30min_R2 3 AGDPGEMPQSPTGLGQPK 18 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9;H0YHL2 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 AGDPGEMPQS(0.363)PT(0.637)GLGQPK;AGDPGEMPQS(0.089)PT(0.911)GLGQPK;AGDPGEMPQS(0.074)PT(0.926)GLGQPK 148.62 0.0019366 13383500.0 103738.0 98640.0 108179.0 122148.0 110326.0 75307.0 88708.0 97771.0 75894.0 96744.0 True False 97972.65725611705 106205.37082240978 101218.88091638955 105511.23168294708 96465.86155304608 85679.85568111786 92833.09777156738 98055.49742313965 91074.92065553693 93950.74934890108 1.0428086836463641 1.1304366549328861 1.0773610813948604 1.1230483249379344 1.0267705390491855 0.911965644498822 0.9881038567006728 1.043690424000717 0.9693900398528563 1.0 16.51961704814137 -6.472388600318024 5.512198080854642 0.9839175454559607 1.0935640024401907 0.6546195085161925 0.037901746632306325 0.130195914281738 9.101104498568846 0.012133391030959551 0.013508239828900894 3.3698564391611725e-07 6.472388600318024 0.10964645698423003 AGDRNS(ph)EDDGVVMTFSSVK ddPTM_A459_Selumetinib_30min_R1 3 AGDRNSEDDGVVMTFSSVK 19 1 Q9NY61 Q9NY61 AATF Protein AATF 1 AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK 158.89 1.2725e-06 59459000.0 11556.400000000001 12955.599999999999 8955.9 6371.9 9807.4 8602.0 14233.6 14865.3 8169.900000000001 14857.5 True False 11825.641635160006 11438.752329104967 7739.737971237323 5259.167280376711 8920.322401637102 8515.471689991093 13159.948092462895 14471.023954700464 13863.723594112882 16764.60484930545 0.7053934012438078 0.6823156544354142 0.4616713630180181 0.31370660553294194 0.5320926130869507 0.5079434777339166 0.7849840906335531 0.8631890870544432 0.8269639349529463 1.0 14.033130857988874 -7.3932312667862075 2.8948058606077023 0.8811338897760902 0.5257936835269098 0.6885401318593216 0.11176563126648484 0.1804201383597532 2.9040029246805226 0.059780822024326746 0.03693372560362068 4.0436050775322756e-08 7.3932312667862075 -0.3553402062491804 AGDRNS(ph)EDDGVVMTFSSVK ddPTM_A459_Selumetinib_30min_R2 7 AGDRNSEDDGVVMTFSSVK 19 1 Q9NY61 Q9NY61 AATF Protein AATF 1 AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK;AGDRNS(1)EDDGVVMTFSSVK 166.61 3.6168e-06 91266700.0 334192.5 212077.4 287313.6 374763.5 373944.9 330895.8 485949.0 499135.8 429890.6 249915.2 True False 315619.41872857476 228343.05464367953 268828.1557793946 323720.0647969028 326966.5985521782 376473.69287699764 508546.59138967644 500588.2025416197 515880.73214695766 242699.4988183288 1.3004535248951201 0.9408468322161815 1.107658471023973 1.3338307922886212 1.3472075556156258 1.5511927083079997 2.0953755317407796 2.0625844098521684 2.1255945507045193 1.0 17.88881160372084 -6.807457108455367 1.7784225841279448 1.9058100359492989 1.1532634461717113 0.4360071413194526 0.32479918603162994 0.2800042202592692 1.8282450504794299 0.13294544835560188 0.11733680293783075 1.5579118888420185e-07 6.807457108455367 -0.7525465897775876 AGDSAVLVLPPS(ph)PGPR ddPTM_A459_Selumetinib_30min_R1 3 AGDSAVLVLPPSPGPR 16 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;A0A087WVI1 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 AGDSAVLVLPPS(1)PGPR;AGDSAVLVLPPS(1)PGPR;AGDSAVLVLPPS(1)PGPR 170.47 9.6093e-06 48371700.0 7655.7 9059.1 9192.0 9802.099999999999 8281.300000000001 8298.1 8528.5 7891.5 4960.8 5772.0 True False 7834.062914600953 7998.456360538673 7943.7768880417925 8090.347243205416 7532.25787718227 8214.62864807197 7885.188378665259 7682.191784795378 8418.11527750342 6512.892424041124 1.2028546465289331 1.2280958811808202 1.2197003068435195 1.2422049554114256 1.1565150146466951 1.2612873226263042 1.2107045326832915 1.1795361084789309 1.2925309876806075 1.0 12.669082681982067 -10.663617141142034 4.440909473200218 0.9999676501390172 1.2199509820655523 0.7647784568139053 0.03684217326817271 24472025.100602463 0.5552527927858878 8409.628247435881 0.008293942452220102 2.169615919674435e-11 10.663617141142034 0.21998333192653508 AGDSAVLVLPPS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 3 AGDSAVLVLPPSPGPR 16 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;A0A087WVI1 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 AGDSAVLVLPPS(1)PGPR;AGDSAVLVLPPS(1)PGPR;AGDSAVLVLPPS(1)PGPR 138.98 0.00040327 12619700.0 51854.0 57412.0 64012.0 63684.0 74628.0 53563.0 55461.0 51775.0 60489.0 66421.0 True False 48972.1622680087 61815.31579132396 59893.53761099595 55010.129338972416 65252.56345721518 60940.81705349721 58040.04639388664 51925.65667818736 72588.49020387349 64503.25314751667 0.759220037414409 0.9583286543696411 0.9285351464990693 0.8528272087791632 1.0116166282029972 0.9447712181915493 0.8998002978415848 0.8050083390280365 1.1253461904916047 1.0 15.97708430258824 -4.7575011102574445 24.958596951635904 0.9381643775096207 0.7592197734635171 0.3037309937735605 0.08442964580202551 144.35186795050979 914692.605629616 0.019945203984810592 0.14735876929145106 1.7478287941541908e-05 4.7575011102574445 -0.17894460404610357 AGDT(ph)SDQEGHSLEEK ddPTM_A459_Selumetinib_30min_R2 1 AGDTSDQEGHSLEEK 15 0 A0A087WU18;Q99607 A0A087WU18 ELF4 ETS-related transcription factor Elf-4 1 AGDT(0.5)S(0.5)DQEGHSLEEK 99.092 0.011467 17658000.0 156930.0 123470.0 157250.0 137010.0 152760.0 106570.0 123400.0 145220.0 101590.0 135130.0 True False 148208.45884056395 132939.75198137626 147132.70620085456 118349.00164456709 133568.92310827266 121249.05015385992 129138.34451246119 145642.56615753475 121910.83866176492 131228.44579009534 1.1293927772156103 1.013040664933411 1.1211952204036513 0.9018547840905669 1.0178351370702126 0.9239540209734876 0.9840728032321792 1.1098399076561138 0.9289970473076068 1.0 17.001720954698513 -5.744991110227248 24.999516132232436 0.9848067757641206 1.0803926665377008 0.37687612049874575 0.06265502843384761 283.7409952019899 431250.9004335526 0.01662800954703373 0.02869315053191918 1.7989077374186895e-06 5.744991110227248 0.09558589077358026 AGDTS(ph)DQEGHSLEEK ddPTM_A459_Selumetinib_30min_R1 2 AGDTSDQEGHSLEEK 15 0 A0A087WU18;Q99607 A0A087WU18 ELF4 ETS-related transcription factor Elf-4 1 AGDT(0.118)S(0.882)DQEGHSLEEK;AGDT(0.028)S(0.972)DQEGHSLEEK 302.15 1.0149999999999996e-80 19526300.0 5552.5 6613.6 7798.200000000001 7234.9 5928.0 5192.2 5918.0 6012.299999999999 3433.8999999999996 4878.5 True False 5681.862446715755 5839.276637420774 6739.247272446426 5971.460530893058 5391.813446673405 5139.971182140405 5471.600495390866 5852.83427329725 5827.077497867076 5504.7029956141105 1.0321832896784435 1.060779599203306 1.2242708240237379 1.084792501185048 0.9794921635135174 0.9337417815703578 0.9939865056753072 1.0632425178907043 1.0585634688210823 1.0 12.42644901042923 -6.151841294348213 5.350063167277039 1.0042310061453303 1.1089108925155078 0.3951705756975379 0.05815290861817288 0.24993952101743352 10.280805274758626 0.018871885512234315 0.024601021127933734 7.049506343168696e-07 6.151841294348213 0.10467988637017744 AGEAPTENPAPPTQQS(ph)SAE ddPTM_A459_Selumetinib_30min_R1 1 AGEAPTENPAPPTQQSSAE 19 0 P16989-2;P16989 P16989-2 YBX3 Y-box-binding protein 3 1 AGEAPTENPAPPT(0.089)QQS(0.455)S(0.455)AE 114.58 0.00048321 4032400.0 926.8 1148.2 895.08 1077.6 896.93 809.66 881.43 679.27 364.84 735.49 True False 948.3926367611278 1013.7682102163022 773.5330523225027 889.4173890572583 815.8028398658525 801.5155555124612 814.9430254566354 661.2535530200789 619.1068331406921 829.8973057792803 1.1427831252814822 1.221558623165267 0.9320828576448371 1.0717198174563156 0.9830166144470214 0.9658008887736196 0.9819805652837942 0.7967896129017511 0.7460041487414467 1.0 9.69678901345204 -5.74346748665292 0.48420991842166067 0.8544503400608445 1.2474999861773717 0.5435248320999162 0.09172600999727887 1.5322128293170858 0.5314227221523294 0.0725915191833243 0.31386800248826113 1.8052298801534022e-06 5.74346748665292 0.39304964611652715 AGEAPTENPAPPTQQSS(ph)AE ddPTM_A459_Selumetinib_30min_R1 1 AGEAPTENPAPPTQQSSAE 19 0 P16989-2;P16989 P16989-2 YBX3 Y-box-binding protein 3 1 AGEAPTENPAPPT(0.003)QQS(0.233)S(0.764)AE 75.483 0.0092621 3245600.0 1127.2 1203.1 1255.6 1279.1 1329.8 1177.2 1071.9 1159.7 559.89 858.32 True False 1153.4615668506078 1062.2404926939837 1085.0964165171094 1055.7291966807159 1209.5198247952585 1165.358436812081 991.0457200083589 1128.9409887635052 950.0924372523358 968.4937327447994 1.1909850604624903 1.0967964549274856 1.1203959094725862 1.090073338614885 1.248866961035844 1.20326894992841 1.0232856305632925 1.1656667984458542 0.9810000882088181 1.0 9.919598902756839 -8.200185922509439 1.4371789206409498 0.9859171359273725 1.146432656536928 0.4384869918294836 0.06469513368665777 0.3979557196009482 1.5362829866106438 0.06089977050029136 0.019084463788119232 6.3068728793760405e-09 8.200185922509439 0.16051552060955554 AGEAPTENPAPPTQQSS(ph)AE ddPTM_A459_Selumetinib_30min_R2 2 AGEAPTENPAPPTQQSSAE 19 0 P16989-2;P16989 P16989-2 YBX3 Y-box-binding protein 3 1 AGEAPTENPAPPTQQS(0.192)S(0.807)AE;AGEAPTENPAPPTQQS(0.068)S(0.932)AE 134.33 0.00038642 0.0 31407.0 30995.0 37362.0 36863.0 37303.0 32741.0 28375.0 32260.0 28354.0 34835.0 True False 29661.524672182473 33372.216835366904 34958.16959666984 31842.19580777808 32616.66364694881 37250.77555679394 29694.49372399585 32353.87125906949 34025.59227695328 33829.22303780042 0.8768018301525577 0.9864907863262818 1.0333719328288429 0.941262995375269 0.9641564516720734 1.1011419184877618 0.8777764032835024 0.9563882452433984 1.0058047221165394 1.0 15.045982422410455 -4.760471767936098 24.80939625031708 0.9835399534724057 0.8768016989890044 0.25271812066755706 0.055834590234365926 32.03633504130798 820939.0537403675 0.013750434476816677 0.08127091346652932 1.7359141053023056e-05 4.760471767936098 -0.10673825448340135 AGEARPGPTAES(ph)ASGPSEDPSVNFLK ddPTM_A459_Selumetinib_30min_R1 1 AGEARPGPTAESASGPSEDPSVNFLK 26 1 Q13501;Q13501-2;E7EMC7;E9PFW8 Q13501 SQSTM1 Sequestosome-1 1 AGEARPGPT(0.005)AES(0.8)AS(0.151)GPS(0.043)EDPS(0.001)VNFLK 89.39200000000002 2.8588e-05 11365000.0 923.05 817.15 1813.9 1793.2 1216.7 877.49 950.94 974.42 565.64 606.7 True False 944.5552690573571 721.4776981172716 1567.5823430394923 1480.0512825329208 1106.6496998258322 868.6632472971731 879.2098301938141 948.5752162377635 959.8497672889524 684.5758547584461 1.3797671397432578 1.0539046814203612 2.2898592349457267 2.1619974941347584 1.6165479575909314 1.268907223734443 1.284313234366183 1.3856393117640267 1.4021087080665988 1.0 9.419066598636423 -6.675425179128518 4.670781721096917 1.2932910696427506 1.7326306894948398 0.2827153072001496 0.3449893929122363 0.3284025533276539 12.727575218478677 0.12868861026162826 0.12709469738977663 2.1114209230777725e-07 6.675425179128518 0.43933961985208914 AGEARPGPTAESASGPS(ph)EDPSVNFLK ddPTM_A459_Selumetinib_30min_R1 1 AGEARPGPTAESASGPSEDPSVNFLK 26 1 Q13501;Q13501-2;E7EMC7;E9PFW8 Q13501 SQSTM1 Sequestosome-1 1 AGEARPGPT(0.004)AES(0.395)AS(0.093)GPS(0.507)EDPSVNFLK 91.091 1.972e-05 10965000.0 812.17 736.34 1158.7 1199.5 912.86 800.85 604.95 788.19 404.3 436.26 True False 831.0919807922796 650.1289704848209 1001.3549042835108 990.0298424036578 830.291974178523 792.7941761136213 559.318134451961 767.2846407980571 686.0675710963216 492.25822053225573 1.6883252450180697 1.3207071885602377 2.034206565815788 2.011200221975338 1.6867000682706064 1.6105250111545322 1.136229139753515 1.558703560030807 1.393714807554679 1.0 8.943271488582289 -7.045799745502478 3.870756555070578 1.3191202793325623 1.7501965580089007 0.4782428904079744 0.2328396617974656 0.23787385742847864 7.398667940143134 0.09560353207888365 0.07571947903039702 8.999124382205662e-08 7.045799745502478 0.43107627867633846 AGELTEDEVER ddPTM_A459_Selumetinib_30min_R1 1 AGELTEDEVER 11 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 157.75 0.0078155 13109000.0 1742.4 1697.2 2104.6 2312.1 1891.5 2177.7 2028.9 1922.5 974.17 1690.8 False True 1782.9945298797904 1498.491034993126 1818.8068797402905 1908.3351384922864 1720.4141589714477 2155.794315193398 1875.8584395232376 1871.5090548399046 1653.0953394382973 1907.830649786683 0.9345664564510218 0.7854423741230252 0.9533376979469607 1.0002644305487283 0.901764608490701 1.1299715283609895 0.9832415889392383 0.9809618348720629 0.8664790764437778 1.0 10.897717399634299 -5.447881784237483 6.754574411826282 0.9822893762132806 0.8607107859127463 0.29609027044928626 0.07313261162422385 0.2875276791708859 21.67966942872878 0.018946236845343835 0.03960847751965868 3.565481732917154e-06 5.447881784237483 -0.1215785903005343 AGEPDGES(ph)LDEQPSSSSSK ddPTM_A459_Selumetinib_30min_R1 4 AGEPDGESLDEQPSSSSSK 19 0 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 AGEPDGES(1)LDEQPSSSSSK;AGEPDGES(1)LDEQPSSSSSK;AGEPDGES(0.992)LDEQPS(0.007)SSSSK;AGEPDGES(1)LDEQPSSSSSK 298.42 3.9105999999999977e-100 90662000.0 17909.0 20587.1 15013.5 16006.5 14851.7 15096.3 17357.1 15999.4 8652.6 13762.0 True False 18326.244855152174 18176.752761316875 12974.749163252332 13211.26525421772 13508.366357280594 14944.444928343695 16047.83997271861 15575.043938624496 14682.830239099761 15528.486753231799 1.1801693974680505 1.1705424392066996 0.8355449806177682 0.8507760906881788 0.8699087407515239 0.9623890058207667 1.0334451919069785 1.0029981791614697 0.9455416018591741 1.0 13.922629625889053 -3.006988365994287 8.095701607441033 0.9799899133725555 1.0677104638905717 0.0 0.11460551246287037 0.0 0.0 0.028796827980932475 0.0 0.0009840374660872269 3.006988365994287 0.0877205505180162 AGEPDGES(ph)LDEQPSSSSSK ddPTM_A459_Selumetinib_30min_R2 4 AGEPDGESLDEQPSSSSSK 19 0 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 AGEPDGES(1)LDEQPSSSSSK;AGEPDGES(1)LDEQPSSSSSK;AGEPDGES(0.991)LDEQPS(0.006)S(0.001)S(0.002)SSK;AGEPDGES(1)LDEQPSSSSSK 274.27 4.1894e-59 123713000.0 369629.0 376379.0 396435.0 417070.0 397631.0 454318.0 451890.0 434083.0 372474.0 395338.0 True False 349086.49992212333 405246.05905076745 370928.80370579235 360264.3465141196 347677.0389137574 516896.1806118168 472903.78040304803 435346.1096636903 446979.2077931116 383923.56472851854 0.9092604153354605 1.0555383838898416 0.9661527391997543 0.9383751861359984 0.9055892132060404 1.346351795252074 1.2317654446073127 1.1339395381253399 1.1642400958356938 1.0 18.55045958808251 -6.744134042735957 24.999982586439508 1.1871622534900015 0.9602674165770646 0.5982222316144883 0.08994472347106011 165.45923343806635 239028.59687477056 0.029516864498526366 0.02944952285748695 1.802461334669736e-07 6.744134042735957 -0.22689483691293688 AGEPDGES(ph)LDEQPSSSSSKR ddPTM_A459_Selumetinib_30min_R1 1 AGEPDGESLDEQPSSSSSKR 20 1 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 AGEPDGES(1)LDEQPSSSSSKR 100.47 0.000389 10236000.0 1727.6 1446.2 3109.6 3183.3 2144.6 1956.9 1959.4 1588.8 1020.2 1401.5 True False 1767.8497186755767 1276.8782316798608 2687.3333998101366 2627.396412941695 1950.6213086598818 1937.2153627230373 1811.6008804780106 1546.6598628502688 1731.2048875401122 1581.3961767660503 1.1179043838912164 0.8074372825986417 1.6993422896125399 1.6614409795239997 1.2334804758722104 1.2250031909680192 1.1455705452524414 0.9780344012296671 1.0947319292755722 1.0 10.626983126523363 -7.283053718025938 1.7697728758491065 1.0280426027371399 1.314241439844116 0.201594779314745 0.24109513660622936 0.6759147124865953 4.127016111542808 0.14583728758466827 0.08867228729676839 5.211302483482766e-08 7.283053718025938 0.28619883710697613 AGEPDGESLDEQPS(ph)SSSSKR ddPTM_A459_Selumetinib_30min_R2 1 AGEPDGESLDEQPSSSSSKR 20 1 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 AGEPDGESLDEQPS(0.222)S(0.222)S(0.222)S(0.222)S(0.11)KR 70.17399999999999 0.037464 0.0 16495.0 11353.0 13006.0 17254.0 11147.0 9939.1 10882.0 7962.8 9064.7 9797.0 True False 15578.273934716779 12223.73859435136 12169.208119862104 14903.975435189845 9746.614204555623 11308.120806833345 11388.034562273931 7985.970429687502 10877.893288879814 9514.135154337044 1.637382030211688 1.2847976611704046 1.2790661392186276 1.5665086940031356 1.0244351216844552 1.1885600344534215 1.1969595110368667 0.839379544240243 1.1433402103733092 1.0 13.215856804508055 -6.09041665903633 0.45572963203118194 0.9758380345067993 1.5861824636576338 0.562303321959313 0.15384135089858642 1.305918876307907 0.46905926346477095 0.13259469068547317 0.3826832855855553 8.120510663085467e-07 6.09041665903633 0.6103444291508345 AGEPNS(ph)PDAEEANS(ph)PDVTAGCDPAGVHPPR ddPTM_A459_Selumetinib_30min_R1 3 AGEPNSPDAEEANSPDVTAGCDPAGVHPPR 30 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 2 AGEPNS(0.973)PDAEEANS(0.994)PDVT(0.033)AGCDPAGVHPPR;AGEPNS(1)PDAEEANS(0.997)PDVT(0.003)AGCDPAGVHPPR;AGEPNS(1)PDAEEANS(1)PDVTAGCDPAGVHPPR 148.76 4.9235e-19 80525000.0 2465.0499999999997 2302.2599999999998 2719.75 3069.7 2855.3 2389.7200000000003 2699.77 2440.02 1400.3600000000001 2038.1999999999998 True False 2522.4808688476683 2032.7103289083625 2350.4228885173707 2533.634520405592 2597.0386191441603 2365.6815864921564 2496.1241753027043 2375.30274329803 2376.3086417522763 2299.8228237492413 1.0968153036830215 0.8838551856766845 1.0220017230221412 1.101665090998264 1.1292342141862863 1.028636450626901 1.0853549888827725 1.0328198845447316 1.0332572653915773 1.0 11.167307006203863 -5.522782385962082 24.99938242321237 1.062792932193498 0.9809835479465642 0.16980577856363466 0.060138013140212464 4.340497284591069 1126043.2931024476 0.015581710895798 0.027371253203073254 3.0006657004379457e-06 5.522782385962082 -0.08180938424693374 AGEPNS(ph)PDAEEANS(ph)PDVTAGCDPAGVHPPR ddPTM_A459_Selumetinib_30min_R2 5 AGEPNSPDAEEANSPDVTAGCDPAGVHPPR 30 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 2 AGEPNS(1)PDAEEANS(0.996)PDVT(0.004)AGCDPAGVHPPR;AGEPNS(1)PDAEEANS(0.998)PDVT(0.002)AGCDPAGVHPPR;AGEPNS(1)PDAEEANS(1)PDVTAGCDPAGVHPPR;AGEPNS(0.997)PDAEEANS(0.999)PDVT(0.004)AGCDPAGVHPPR;AGEPNS(0.983)PDAEEANS(1)PDVT(0.018)AGCDPAGVHPPR 124.44 2.5621000000000003e-16 254447400.0 123873.6 125729.1 139342.5 147442.7 145994.5 108642.6 114527.6 123199.1 106839.6 130997.9 True False 116989.20121731023 135372.11768722493 130377.35525464272 127360.74990715548 127653.36570261022 123607.13199067042 119853.3603321341 123557.58898429113 128210.50534784432 127215.65025358068 0.919613278587297 1.0641152831226808 1.0248531135497856 1.0011405802138775 1.0034407358540953 0.9716346357093851 0.9421274826896595 0.9712451945810292 1.0078202256741255 1.0 16.95691663841089 -6.7166834166457 5.455837576471317 0.974455509651725 1.0075528858454428 0.08145838651929438 0.037563699191936875 0.3812364609547956 26.130270901070112 0.012528359565704783 0.012263702227854214 1.9200678835486758e-07 6.7166834166457 0.033097376193717776 AGEPNS(ph)PDAEEANSPDVTAGCDPAGVHPPR ddPTM_A459_Selumetinib_30min_R1 4 AGEPNSPDAEEANSPDVTAGCDPAGVHPPR 30 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 AGEPNS(1)PDAEEANSPDVTAGCDPAGVHPPR;AGEPNS(0.998)PDAEEANS(0.002)PDVTAGCDPAGVHPPR;AGEPNS(0.984)PDAEEANS(0.016)PDVTAGCDPAGVHPPR;AGEPNS(0.998)PDAEEANS(0.002)PDVTAGCDPAGVHPPR 202.03 9.681800000000001e-48 657678600.0 5487.530000000001 5466.13 6129.7 6375.45 5966.709999999999 4653.3 5872.94 5021.19 2779.9300000000003 4222.29 True False 5615.3787721253675 4826.152958465106 5297.320408031957 5262.097339518464 5427.022134008209 4606.492026858353 5429.939407468879 4888.011730076244 4717.338171946071 4764.262050087423 1.1786460763681812 1.0129906599861667 1.1118868677542104 1.1044936832183498 1.1391107535549236 0.9668846882118555 1.139723077862445 1.0259745745905289 0.9901508612145945 1.0 12.218037053020321 -7.850310536608271 0.76657166591583 0.9884350726906744 1.0979909334569415 0.29328600751890643 0.06026562751841658 0.8464397111204718 0.9597619128655485 0.05390031686015595 0.024144927016454616 1.4115278890773871e-08 7.850310536608271 0.10955586076626711 AGEPNS(ph)PDAEEANSPDVTAGCDPAGVHPPR ddPTM_A459_Selumetinib_30min_R2 1 AGEPNSPDAEEANSPDVTAGCDPAGVHPPR 30 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 AGEPNS(0.776)PDAEEANS(0.223)PDVT(0.001)AGCDPAGVHPPR 71.173 0.00013754 11692000.0 49022.0 44087.0 50424.0 55131.0 43564.0 45387.0 55843.0 51815.0 47846.0 44213.0 True False 46297.55349061451 47468.33113795194 47179.77473750013 47622.06269372031 38091.100852898635 51638.6472678356 58439.81015080527 51965.773071564996 57416.53692893796 42936.45581083022 1.0782807433988646 1.1055484259597086 1.0988278805629685 1.109128869498078 0.8871505608362439 1.2026760544779374 1.3610767131847084 1.2102948902097606 1.337244442855372 1.0 15.389915488418067 -6.980935372550742 24.81959129940819 1.249992584330839 1.0620070094358076 0.3592906367330436 0.10969798670539525 213.37137478729505 277779.83399377484 0.03668087058545827 0.032344895441535064 1.0448756958148473e-07 6.980935372550742 -0.18798557489503143 AGEPNSPDAEEANS(ph)PDVTAGCDPAGVHPPR ddPTM_A459_Selumetinib_30min_R1 3 AGEPNSPDAEEANSPDVTAGCDPAGVHPPR 30 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 AGEPNSPDAEEANS(0.994)PDVT(0.006)AGCDPAGVHPPR;AGEPNSPDAEEANS(0.999)PDVT(0.001)AGCDPAGVHPPR;AGEPNS(0.001)PDAEEANS(0.999)PDVTAGCDPAGVHPPR 201.29 1.1587e-47 188743700.0 2401.8599999999997 2130.79 2375.67 2383.37 2325.23 1725.6599999999999 1776.48 1859.4499999999998 971.9300000000001 1874.77 True False 2457.8186647940042 1881.316116222603 2053.067062621218 1967.1591708958772 2114.9133570527006 1708.3014271739157 1642.4786833477476 1810.1313456551675 1649.294223041425 2115.4149913062342 1.161861230489031 0.8893366663062744 0.9705268569329192 0.9299164367182576 0.999762867212535 0.8075490786415707 0.7764333192767741 0.8556861670614525 0.7796551645041585 1.0 11.046724996314708 -6.760616881397764 24.99913299570277 0.8306306541194428 0.9802217992315753 0.3959862977634727 0.08924227908456295 21.835962212203025 663691.8466470946 0.02879129440455845 0.02720351456085647 1.7353341706382367e-07 6.760616881397764 0.14959114511213245 AGEPNSPDAEEANS(ph)PDVTAGCDPAGVHPPR ddPTM_A459_Selumetinib_30min_R2 3 AGEPNSPDAEEANSPDVTAGCDPAGVHPPR 30 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 AGEPNSPDAEEANS(1)PDVTAGCDPAGVHPPR;AGEPNS(0.004)PDAEEANS(0.996)PDVTAGCDPAGVHPPR;AGEPNS(0.055)PDAEEANS(0.944)PDVT(0.001)AGCDPAGVHPPR 151.06 5.2154e-20 657886800.0 265063.0 277139.8 276507.8 298278.7 338167.6 213108.9 219162.1 208782.3 208323.4 259051.2 True False 250331.8595912601 298395.5315150904 258717.5891869292 257652.6265005424 295683.96283129836 242462.71656501756 229353.57191146226 209389.82192722967 249993.90104213313 251571.71876015016 0.9950715478870176 1.186125105738067 1.0284049036274698 1.0241716667134186 1.1753465941583245 0.9637916287250986 0.9116826527314431 0.8323265546667551 0.9937281594060208 1.0 17.940610220589647 -6.935837873515264 7.082318263629864 0.9227835109335206 1.0811573267771044 0.4878908210558691 0.07257255565283127 0.1719165373859288 15.557490830918525 0.024839917233576935 0.021860796315643586 1.159210020115034e-07 6.935837873515264 0.1583738158435838 AGEQQLS(ph)EPEDMEMEAGDTDDPPR ddPTM_A459_Selumetinib_30min_R2 2 AGEQQLSEPEDMEMEAGDTDDPPR 24 0 Q93009;H3BMF6 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 AGEQQLS(1)EPEDMEMEAGDTDDPPR;AGEQQLS(1)EPEDMEMEAGDTDDPPR 154.19 1.41e-10 13835900.0 69698.0 67673.0 73979.0 73600.0 81154.0 62424.0 63716.0 58454.0 58780.0 72180.0 True False 65824.46418320043 72863.30149700855 69219.27168224515 63575.553032918346 70958.70899403495 71022.339371348 66678.92025085869 58624.091462419325 70537.64245042358 70095.9758538376 0.9390619558597197 1.03947909433405 0.9874928031044101 0.9069786426182941 1.01230788400744 1.0132156447816922 0.9512517578740315 0.8363403283615144 1.0063008837698033 1.0 16.097044002353726 -7.514156764439678 24.690114869987937 0.9315515871543566 0.983597250138566 0.06199561253599406 0.056596055925622744 687.3883569555867 1945873.0157856785 0.024658350142527485 0.015174199823683678 3.0608583762240836e-08 7.514156764439678 0.05204566298420943 AGFAGDDAPR ddPTM_A459_Selumetinib_30min_R1 3 AGFAGDDAPR 10 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38;P0CG39 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 ;; 180.45 0.0017024000000000002 566961000.0 21179.800000000003 22353.0 22634.1 24331.0 23578.1 20820.9 21441.5 19800.9 12588.5 16951.2 False True 21673.248131283286 19735.900368372226 19560.513540211785 20082.04759943592 21445.465018051655 20611.460649864624 19824.150392349307 19275.715809612222 21361.76507233747 19127.051638670473 1.1331201766332346 1.031831812931942 1.0226622434931347 1.049929073168531 1.1212112260257554 1.0776078320504463 1.036445698315022 1.0077724561918986 1.1168352277121962 1.0 14.223326884488625 -11.93088337848118 2.2352042200069286 0.48610589282700756 1.0629325753741985 0.17696738608260665 0.04236248636489057 1108570.2595650821 568590.9099050802 2755019.59731435 0.010693881381836577 1.1725101785741894e-12 11.93088337848118 0.5768266825471909 AGFAGDDAPR ddPTM_A459_Selumetinib_30min_R2 3 AGFAGDDAPR 10 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38;P0CG39 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 ;; 167.23 0.0041864 682608000.0 1113409.0 975613.0 1076871.0 1238546.0 1217691.0 929860.0 925491.0 993179.0 769960.0 1037248.0 False True 1051530.1851093704 1050439.3800097716 1007586.2922684953 1069853.8981889782 1064713.7702843407 1057939.7745713433 968528.1653256246 996068.9864603649 923973.514479896 1007299.9551460425 1.0439096911871848 1.0428267912088556 1.0002842620224393 1.0621006113654263 1.056997734234957 1.0502728300210822 0.9615091913562166 0.9888504227283031 0.917277430381633 1.0 19.942061924331007 -7.263018433177946 24.987774661158586 0.9659801259673565 1.0423356904378882 0.6792968889537578 0.02551864370023824 82.0272058324153 1298020.6783107126 0.010135263529274997 0.007242027216863616 5.4573469745761505e-08 7.263018433177946 0.07635556447053171 AGFS(ph)PDSSKADSDAASSGGSDSK ddPTM_A459_Selumetinib_30min_R2 1 AGFSPDSSKADSDAASSGGSDSK 23 1 O95402;B8ZZF3 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 AGFS(0.738)PDS(0.129)S(0.129)KADS(0.003)DAASSGGSDSK 51.16 0.021813 6769900.0 14267.0 13806.0 12119.0 14874.0 13324.0 11248.0 10432.0 8719.2 4323.2 12304.0 True False 13474.097255326109 14864.875806713195 11339.276734169529 12848.135540918844 11650.120001928684 12797.309900822142 10917.10867061584 8744.571428458741 5187.960800300641 11948.751550368786 1.1276573287617018 1.2440526312771483 0.9489925944455304 1.075270122301798 0.9750073012078919 1.0710164862727576 0.9136610318321411 0.7318397567810211 0.43418433954637875 1.0 13.54457226753096 -7.595941290363503 2.4136423315058755 0.6801030477837079 1.0714841866472316 0.5253826289182659 0.1487864240729603 0.2160997055092352 2.5256508738823724 0.0841100845622086 0.04243925944143202 2.5354713623242977e-08 7.595941290363503 0.39138113886352366 AGFSPDS(ph)SKADSDAASSGGSDSK ddPTM_A459_Selumetinib_30min_R2 1 AGFSPDSSKADSDAASSGGSDSK 23 1 O95402;B8ZZF3 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 AGFS(0.059)PDS(0.464)S(0.464)KADS(0.001)DAAS(0.003)S(0.008)GGS(0.001)DSK 65.223 0.0024422 5330500.0 20444.0 20531.0 24349.0 23474.0 23503.0 16050.0 15776.0 17351.0 14779.0 22928.0 True False 19307.804323816308 22105.661682429996 22782.411849186705 20276.800705091344 20550.343020514112 18260.741812606288 16509.615259550956 17401.488537387322 17735.212959762037 22266.009065901788 0.8671425699446211 0.992798557523389 1.0231924267054997 0.9106616567467081 0.9229468540900286 0.8201174156787183 0.7414716849654847 0.7815270570439136 0.7965151234453497 1.0 14.44255537383128 -6.678141536089963 2.69884782632845 0.8070036821814077 0.9549016809184429 0.3523908957788272 0.0762181406320951 0.2530691526526395 3.7481752415702614 0.02699868815328002 0.026294199903761327 2.098255952895637e-07 6.678141536089963 0.14789799873703513 AGFSPDSS(ph)KADSDAASSGGSDSK ddPTM_A459_Selumetinib_30min_R1 1 AGFSPDSSKADSDAASSGGSDSK 23 1 O95402;B8ZZF3 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 AGFS(0.002)PDS(0.395)S(0.573)KADS(0.029)DAASS(0.001)GGSDSK 75.868 0.00048509 11236000.0 1385.5 1527.8 2303.6 2310.6 1565.4 1701.4 1547.7 1600.3 806.28 1194.3 True False 1417.7794542862991 1348.924465745049 1990.7837727690473 1907.0970853337983 1423.8098463938172 1684.285460747598 1430.955742939582 1557.8548454930035 1368.1982716387383 1347.6000384671372 1.0520773328998931 1.0009828044227562 1.4772808815243996 1.415180343496484 1.056552245288867 1.2498407633346704 1.0618549288313022 1.1560216689107743 1.0152851236150386 1.0 10.396176659416012 -7.780645167383994 0.9302221023925433 1.0071417987113016 1.2182173907534144 0.20041858878357033 0.14865155552480486 1.026300736061207 1.6216814778419537 0.14353138120887765 0.05955848522727239 1.6571233337963567e-08 7.780645167383994 0.2110755920421128 AGGAS(ph)PAASSTAQPPTQHR ddPTM_A459_Selumetinib_30min_R1 6 AGGASPAASSTAQPPTQHR 19 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR 191.66 1.9717e-15 542795000.0 6280.89 6429.79 7318.89 7781.02 7326.41 6067.64 7104.03 6654.360000000001 4045.1100000000006 5378.3 True False 6427.222516515538 5676.987197671723 6325.024937785056 6422.210924835108 6663.73750908274 6006.60505057633 6568.167297612634 6477.864756392447 6864.256226854916 6068.657194078377 1.059084787782549 0.9354601876690557 1.0422445584761049 1.0582589721992732 1.0980579881139152 0.9897749796177981 1.0823098236660433 1.0674296717094784 1.131099682735888 1.0 12.567161612715374 -5.504879013958095 20.62847449382378 1.06226426645794 0.9951673479466546 0.21360410928296936 0.04821407770729785 99.73669128352475 114299.06269210369 0.012120537362646672 0.024273431663603053 3.126950353680849e-06 5.504879013958095 -0.06709691851128541 AGGAS(ph)PAASSTAQPPTQHR ddPTM_A459_Selumetinib_30min_R2 6 AGGASPAASSTAQPPTQHR 19 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 AGGAS(0.992)PAASSTAQPPT(0.007)QHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR;AGGAS(1)PAASSTAQPPTQHR 141.5 6.8248e-05 533924700.0 56554.299999999996 52463.100000000006 60756.100000000006 62523.40000000001 64057.0 48524.600000000006 47235.0 46947.5 48919.1 55888.200000000004 True False 53411.238410800404 56486.85107454548 56847.11867224003 54007.605061119095 56009.58698315418 55208.42318753861 49431.521094376825 47084.10945242301 58704.286913857126 54274.56245101764 0.9840933947464545 1.0407610586547686 1.047398930641663 0.9950813534399384 1.0319675452695245 1.0172062324291193 0.9107677494219945 0.8675170710941436 1.081616953924544 1.0 15.727988569762665 -7.163222327605281 8.21447708232554 0.9540445464205233 1.021405440209087 0.1759963225572274 0.055679066928671916 0.4425752075127526 33.3526219199452 0.02084830016544491 0.016138640549232752 6.867168002988941e-08 7.163222327605281 0.0673608937885638 AGGDLSLS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 AGGDLSLSPGR 11 0 A0A1B0GVM0;A0A1B0GTT1;Q9BUH8 A0A1B0GVM0 BEGAIN Brain-enriched guanylate kinase-associated protein 1 AGGDLS(0.002)LS(0.998)PGR 108.98 0.0096569 3224900.0 21157.0 20091.0 17978.0 24784.0 23113.0 19157.0 26445.0 21440.0 16273.0 21548.0 True False 19981.17863818144 21631.91509725299 16821.31505296639 21408.37644521531 20209.33830715833 21795.70286006845 27674.744899773374 21502.38685041694 19528.054705609826 20925.853251572382 0.9548561006314065 1.0337411257353415 0.8038532455876047 1.023058710574044 0.9657593439177821 1.041568178751837 1.3225145262687854 1.0275512588143203 0.9332023153771508 1.0 14.352998829408229 -6.833856685164403 4.305516219546877 1.086219394393805 0.9552431821758172 0.1876742852069987 0.11155378528193964 0.34067770764149885 12.129807289534252 0.04136023601146913 0.036912696885566296 1.4660315436406522e-07 6.833856685164403 -0.13097621221798783 AGGDSGNVDDDCER ddPTM_A459_Selumetinib_30min_R2 1 AGGDSGNVDDDCER 14 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 0 153.81 0.0010885 0.0 3587.7 4642.5 4423.2 4939.8 4437.1 3910.3 4012.0 4401.7 2561.3 4018.9 False True 3388.3099967010253 4998.564822009708 4138.6161276160265 4266.990718369697 3879.671829822712 4448.9083308308 4198.565949627185 4414.508218259337 3073.6315687014344 3902.8639146437845 0.8681599130289628 1.280742790763159 1.0604049277987084 1.093297335415587 0.9940576752537914 1.1399086486562402 1.0757653972699146 1.1310945794691514 0.7875323444327589 1.0 11.930317444315373 -8.249962310947188 24.879308832269782 0.8937661641772298 1.0858156894860447 0.31249332354394677 0.11051711667776719 654.9455305846508 1419760.5692703275 0.07008207864414762 0.02596325710617033 5.623901285540795e-09 8.249962310947188 0.19204952530881492 AGGEEEDDDDEAAGGR ddPTM_A459_Selumetinib_30min_R1 1 AGGEEEDDDDEAAGGR 16 0 Q6DD87 Q6DD87 ZNF787 Zinc finger protein 787 0 200.21 5.470600000000001e-20 0.0 77.212 190.22 0.0 229.89 144.6 0.0 289.27 153.74 0.0 234.7 False True 79.01088937160144 167.94895396912116 0.0 189.74402706975974 131.5209555312035 0.0 267.45013100738686 149.66231578209982 0.0 264.8260311715959 0.298350162263338 0.634185971923196 0.0 0.7164855593323972 0.4966315242854037 0.0 1.0099087685005204 0.5651344587236784 0.0 1.0 8.048901129126676 -10.981060876522383 3.0892734192523563 1.0120422063514938 0.42895398881264285 0.22577476135428098 0.3247291710429621 171113298.29561737 208078897.39602867 17869353.095011286 0.07888983635990013 1.0445737875270324e-11 10.981060876522383 -0.583088217538851 AGGGATPVSS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 AGGGATPVSSPSR 13 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 AGGGATPVS(0.109)S(0.889)PS(0.002)R;AGGGATPVS(0.029)S(0.672)PS(0.299)R 121.56 0.0028177 7579100.0 42487.0 44426.0 52052.0 53147.0 60895.0 39494.0 33650.0 35683.0 36648.0 42060.0 True False 40125.742628936765 47833.33134789518 48703.0309899325 45908.28691631125 53244.8256917928 44933.94000916339 35214.79167621004 35786.831622361344 43978.62403067587 40845.61851499601 0.9823756889421335 1.1710761909587368 1.1923685516489788 1.1239464252317917 1.3035627229452913 1.1000920451887979 0.8621436755396746 0.8761486035331455 1.076703588526383 1.0 15.317893709188274 -7.089760871654622 5.6805147607259565 0.9453812802217954 1.1601846346873752 0.509236799771619 0.09318825261904458 0.17962428389561963 8.96972090276345 0.03596893536830955 0.027892790982357328 8.132781947460559e-08 7.089760871654622 0.21480335446557985 AGGGGGLGAGS(ph)PALSGGQGR ddPTM_A459_Selumetinib_30min_R1 4 AGGGGGLGAGSPALSGGQGR 20 0 A0A3B3ITT1;Q6IQ22 A0A3B3ITT1 RAB12 Ras-related protein Rab-12 1 AGGGGGLGAGS(0.981)PALS(0.019)GGQGR;AGGGGGLGAGS(0.996)PALS(0.004)GGQGR;AGGGGGLGAGS(1)PALSGGQGR;AGGGGGLGAGS(1)PALSGGQGR 265.93 1.3503999999999998e-48 131341000.0 7847.699999999999 8993.3 8797.3 7930.9 9180.8 8156.0 8263.2 8551.5 4202.299999999999 7345.6 True False 8030.536141033994 7940.360255128259 7602.674980109883 6545.917196431156 8350.398261001888 8073.958045055491 7639.900171259511 8324.686440813237 7130.996176151551 8288.479312203131 0.9688793129049176 0.9579996469844189 0.9172581234432788 0.7897609380279926 1.0074704836033788 0.9741181392789627 0.9217493201691754 1.0043683680982105 0.8603503619358236 1.0 13.016891719315872 AGGGGGLGAGS(ph)PALSGGQGR ddPTM_A459_Selumetinib_30min_R2 3 AGGGGGLGAGSPALSGGQGR 20 0 A0A3B3ITT1;Q6IQ22 A0A3B3ITT1 RAB12 Ras-related protein Rab-12 1 AGGGGGLGAGS(0.79)PALS(0.21)GGQGR;AGGGGGLGAGS(1)PALSGGQGR;AGGGGGLGAGS(0.982)PALS(0.018)GGQGR 216.9 2.4287e-19 130459500.0 190499.0 105932.0 146096.0 173881.0 153694.0 121839.0 166274.0 131116.0 113493.0 130509.0 True False 179911.82820791844 114056.64377493429 136696.34241729774 150198.10783854398 134385.58567820693 138621.21630567836 174006.07046568068 131497.52585257762 136194.77125937285 126740.86606689513 1.419525002401034 0.8999200282782825 1.0785498526193438 1.185080333593964 1.060317716365271 1.0937373288305656 1.372927895047194 1.0375305924071236 1.0745923985361425 1.0 16.951522253580073 AGGIETIANEYSDR ddPTM_A459_Selumetinib_30min_R1 1 AGGIETIANEYSDR 14 0 A0A087WYC1;P34932;A0A087WTS8;P34932-2 A0A087WYC1 HSPA4 Heat shock 70 kDa protein 4 0 125.23 0.019346 3190500.0 682.88 866.16 885.53 1084.4 968.34 645.58 927.73 779.0 488.33 850.86 False True 698.7897753468266 764.7495845331406 765.2798898681075 895.0298967090679 880.7538179743127 639.0860513397405 857.7505791802919 758.338389451384 828.6603437879462 960.076169078245 0.7278482664742364 0.7965509499807347 0.7971033075457351 0.9322488418480097 0.9173791063056085 0.6656618213462351 0.8934193002663586 0.7898731516057247 0.8631193758132032 1.0 9.907005058517106 -14.522878745177545 0.2375842586534284 2.0005192801572154 0.8037845871961731 0.3331242004416445 0.078612476235884 213.2332668029406 2.124594503044948 102.95854120639015 0.12943227819761818 3.000000000710066e-15 14.522878745177545 -1.1967346929610423 AGGKPSQS(ph)PSQEAAGEAVLGAK ddPTM_A459_Selumetinib_30min_R2 1 AGGKPSQSPSQEAAGEAVLGAK 22 1 P00519;P00519-2 P00519 ABL1 Tyrosine-protein kinase ABL1 1 AGGKPS(0.011)QS(0.983)PS(0.007)QEAAGEAVLGAK 107.91 3.1279e-05 4275400.0 23760.0 23312.0 31198.0 27887.0 30305.0 22232.0 26132.0 26240.0 18205.0 25296.0 True False 22439.514318816047 25099.95544010561 29190.75464581408 24088.74249224173 26497.814969862586 25294.256197997707 27347.18977957564 26316.35405573414 21846.50869020013 24565.63875309888 0.9134512863413891 1.0217505716980115 1.1882758245857439 0.9805868568837035 1.0786536119082175 1.02966002440327 1.1132293385257843 1.0712668341430533 0.8893116482649678 1.0 14.584354131927503 -8.248871232609075 24.84535617145375 0.9446558217345773 1.05342597864099 0.24043915255127601 0.07436949412399849 843.7922966744572 1668060.5597042998 0.05023007969392932 0.018703625321915912 5.638047979704899e-09 8.248871232609075 0.10877015690641278 AGGLDWPEATEVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 4 AGGLDWPEATEVSPSR 16 0 Q9Y446;Q9Y446-2;E9PKC4;E9PK71;E9PJR7;E9PRW6 Q9Y446 PKP3 Plakophilin-3 1 AGGLDWPEAT(0.007)EVS(0.986)PS(0.007)R;AGGLDWPEATEVS(0.998)PS(0.002)R;AGGLDWPEATEVS(0.916)PS(0.084)R;AGGLDWPEATEVS(0.981)PS(0.019)R 316.86 2.6921999999999987e-103 276517000.0 11500.300000000001 11656.300000000001 13509.099999999999 13609.7 13521.400000000001 10178.9 11613.6 11382.8 6093.5 9799.0 True False 11768.234614311614 10291.574977133148 11674.638420174655 11233.021380709508 12298.391757397065 10076.509507701736 10737.576801837002 11080.8911674547 10340.22444836862 11056.797100342856 1.0643439060617923 0.9307917006828335 1.055878869280566 1.0159380947997307 1.1122924338564293 0.9113407269985335 0.9711290443689199 1.002179118138208 0.9351916612495299 1.0 13.4326459100897 -6.7780154112461934 24.999075635946948 0.9645518837914289 1.0300191221860806 0.3370505635259463 0.05006923449333261 318.12127789035407 479769.80105502874 0.017389156794704163 0.015377697538941196 1.6671880501567824e-07 6.7780154112461934 0.06546723839465174 AGGLDWPEATEVS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 3 AGGLDWPEATEVSPSR 16 0 Q9Y446;Q9Y446-2;E9PKC4;E9PK71;E9PJR7;E9PRW6 Q9Y446 PKP3 Plakophilin-3 1 AGGLDWPEATEVS(0.899)PS(0.101)R;AGGLDWPEAT(0.005)EVS(0.982)PS(0.013)R;AGGLDWPEATEVS(0.994)PS(0.006)R 203.52 3.5069e-07 86364000.0 110422.0 99708.0 107590.0 116410.0 110627.0 89352.0 90964.0 91940.0 80190.0 92184.0 True False 104285.18729428887 107355.2829882486 100667.77653513466 100554.75718154894 96729.04724207171 101659.4269433021 95194.0062417466 92207.53017851363 96230.24069580622 89522.40839720365 1.1649059622210338 1.1992001210682575 1.1244980819604398 1.123235611975447 1.08050094913547 1.1355752013758107 1.0633539461916455 1.0299938510299713 1.0749290866800687 1.0 16.44996122882135 -3.86466485193024 0.15985186929182618 0.9744960135886543 1.4539154575770188 0.8079091732224354 0.02544684713485138 12.335160149609345 0.2537080050790667 0.09140663305930535 1.2433917521356963 0.00013656366013091721 3.86466485193024 0.47941944398836445 AGGLDWPEATEVSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 AGGLDWPEATEVSPSR 16 0 Q9Y446;Q9Y446-2;E9PKC4;E9PK71;E9PJR7;E9PRW6 Q9Y446 PKP3 Plakophilin-3 1 AGGLDWPEATEVS(0.454)PS(0.546)R 225.17 1.2782e-11 30423000.0 45082.0 40228.0 41483.0 47391.0 43080.0 35659.0 39087.0 44704.0 29917.0 37070.0 True False 42576.52291754484 43313.35824659265 38814.02894327539 40936.26404596505 37667.90525991351 40570.70356982725 40904.622949421166 44834.08123885442 35901.235950822134 35999.69278057307 1.1826912850912135 1.2031591077901183 1.0781766716692944 1.1371281498284331 1.046339630993759 1.1269736055003472 1.1362492229793417 1.245401773624267 0.9972650647228839 1.0 15.135696974275652 -14.522878745277279 0.17069058896405537 0.48578740230852435 1.160941850374255 0.29090762455120656 0.06715466109336876 188.01901144784821 1.770488728629492 32.65671785982701 0.24280447551039522 3.000000000021131e-15 14.522878745277279 0.6751544480657307 AGGPATPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 AGGPATPLSPTR 12 0 Q03252 Q03252 LMNB2 Lamin-B2 1 AGGPATPLS(0.5)PT(0.5)R;AGGPATPLS(0.932)PT(0.068)R 98.368 0.015348 155879000.0 4483.3 4962.799999999999 5547.6 6072.6 5125.0 4575.0 5068.0 5185.1 2562.3 4497.2 True False 4587.752167016795 4381.753068856871 4794.266390785534 5012.134406819885 4661.444654892241 4528.979653767644 4685.716679729791 5047.574304421533 4348.0359570123765 5074.4594264375855 0.9040868753654667 0.8634915959773446 0.9447836681495048 0.9877178997051407 0.9186091094957689 0.8925048508954413 0.9233922839775857 0.9947018746714216 0.8568471223475367 1.0 12.309038427287772 AGGPATPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 AGGPATPLSPTR 12 0 Q03252 Q03252 LMNB2 Lamin-B2 1 AGGPATPLS(0.941)PT(0.059)R;AGGPATPLS(0.665)PT(0.335)R 101.72 0.012273 127591000.0 95096.0 73023.0 95294.0 102517.0 110376.0 80091.0 73886.0 84696.0 86124.0 84650.0 True False 89810.94501944998 78623.62929404726 89162.88778826217 88554.00774831092 96509.58010604039 91122.80825628976 77321.84540233159 84942.45133782235 103351.20650561928 82205.93455288661 1.0925116964842816 0.9564227901753893 1.0846283577118128 1.077221592698278 1.1739977245067585 1.108469951128243 0.9405871464497143 1.0332885551367976 1.2572231806345928 1.0 16.3269549272395 -5.408857082635832 24.02780633797216 1.0842868628089364 1.0234778842941907 0.06848861885911739 0.08843456159414911 44.83374268717355 9384.22241908281 0.02343373522676782 0.04878120604383927 3.900703296648952e-06 5.408857082635832 -0.06080897851474565 AGGPS(ph)DDDNADKPK ddPTM_A459_Selumetinib_30min_R1 4 AGGPSDDDNADKPK 14 1 E7EVA0 E7EVA0 MAP4 Microtubule-associated protein 1 AGGPS(1)DDDNADKPK;AGGPS(1)DDDNADKPK;AGGPS(1)DDDNADKPK;AGGPS(1)DDDNADKPK 209.53 2.4267e-05 71717400.0 5961.170000000001 7968.0 8820.0 10306.2 6284.5 7920.3 6967.699999999999 6412.33 4428.45 6070.849999999999 True False 6100.053662582359 7035.1028557773 7622.29244479206 8506.415641334374 5716.068084618593 7840.628973057019 6442.12077927255 6242.254178216683 7514.756208809065 6850.1027325866335 0.8905054275410769 1.0270069122190828 1.112726734525023 1.2417938786331615 0.834449979476465 1.1446002022361434 0.9404414839834048 0.9112643155732025 1.0970282493809338 1.0 12.741909909331147 -7.325651558296144 24.999981552757102 0.9797889023540474 1.044057458964896 0.04645040138674428 0.11921648290299842 691.7130617671654 269304.1789713947 0.04990312235867903 0.03364467907042208 4.724419372893137e-08 7.325651558296144 0.06426855661084874 AGGPS(ph)DDDNADKPK ddPTM_A459_Selumetinib_30min_R2 4 AGGPSDDDNADKPK 14 1 E7EVA0 E7EVA0 MAP4 Microtubule-associated protein 1 AGGPS(1)DDDNADKPK;AGGPS(1)DDDNADKPK;AGGPS(1)DDDNADKPK;AGGPS(1)DDDNADKPK 238.64 9.3314e-19 30961600.0 181145.0 184412.0 161036.0 143777.0 134259.0 113459.0 133928.0 142330.0 90858.0 158138.0 True False 171077.6860808895 198555.80742196066 150675.11908274016 124194.32457084111 117392.1841293112 129086.9473717442 140155.91737329745 142744.15673600015 109032.13878463063 153572.14504813254 1.1139890377077848 1.2929155046947436 0.9811357328864267 0.8087034568144904 0.7644106559331978 0.840562247348214 0.9126389250431438 0.9294924980780942 0.7099734053363506 1.0 17.228557037857897 -5.4696229031503165 3.98732155854789 0.849135449070635 1.1998478803460084 0.7104884084990064 0.08867921249176339 0.10945255804632344 3.531601669509466 0.023383768684060537 0.0498591905267767 3.391385014727445e-06 5.4696229031503165 0.35071243127537344 AGGPT(ph)TPLSPTR ddPTM_A459_Selumetinib_30min_R1 1 AGGPTTPLSPTR 12 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 AGGPT(0.5)T(0.5)PLSPTR 121.21 0.008987799999999999 37051000.0 4163.6 3806.0 4532.1 4597.0 5190.6 3227.9 3822.2 3823.2 2441.6 3412.8 True False 4260.603779044706 3360.3917506386033 3916.665713043323 3794.220246377337 4721.111146474858 3195.4302566987053 3533.8883767291277 3721.796316496189 4143.21687259159 3850.866123487101 1.1064014282549435 0.872632712454736 1.017086958477964 0.9852900944116777 1.22598682869809 0.8297952082024409 0.9176866355273503 0.966482915050281 1.0759181804117757 1.0 11.910967252944078 AGGPTT(ph)PLSPTR ddPTM_A459_Selumetinib_30min_R1 2 AGGPTTPLSPTR 12 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 AGGPT(0.211)T(0.789)PLSPTR;AGGPT(0.038)T(0.962)PLSPTR 110.98 0.016350999999999997 44739000.0 7209.5 7471.900000000001 8676.8 8903.3 9124.3 7026.0 7517.6 7475.0 4259.0 6386.6 True False 7377.467322755022 6597.086474407928 7498.538218250766 7348.505790639839 8299.008676025998 6955.324819097587 6950.541379545519 7276.7387177780465 7227.211934947397 7206.382320752092 1.0237407612291483 0.9154505243789821 1.0405412708478368 1.0197218886761636 1.1516192600727677 0.9651617843072885 0.9644980060980345 1.0097630674996734 1.0028904397890912 1.0 12.815059477867466 -5.289659737948315 24.94227357059152 1.0204768276389462 0.9695955957763078 0.11432464153498567 0.05522828005777909 1367.4953548435715 1208644.5281943055 0.014951901991533166 0.031135554557910932 5.1326335927209695e-06 5.289659737948315 -0.050881231862638376 AGGPTT(ph)PLSPTR ddPTM_A459_Selumetinib_30min_R2 2 AGGPTTPLSPTR 12 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 AGGPT(0.225)T(0.775)PLSPTR;AGGPT(0.03)T(0.967)PLS(0.002)PTR 145.14 0.0016165 65903000.0 153661.0 133397.0 184312.0 184467.0 195873.0 127641.0 138804.0 148150.0 134113.0 137488.0 True False 145121.13677372033 143628.12096104023 172453.56658373264 159342.2763766759 171265.68261316261 145222.3891403663 145258.661034908 148581.09197244703 160939.34743031065 133518.3642032754 1.0869002001311239 1.0757180992898714 1.2916093423761559 1.1934109388434748 1.2827125589437172 1.087658540508121 1.0879302027229643 1.11281390285938 1.205372372487189 1.0 17.026678659217914 -6.835404746148344 24.999999450795368 1.1051288802658408 1.1862210470343273 0.22674290701708033 0.08019080689116592 71.84904677104149 24282.478059186826 0.02934834495204996 0.02588281237960837 1.4608151150310567e-07 6.835404746148344 0.08109216676848652 AGGPTTPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 AGGPTTPLSPTR 12 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 AGGPTTPLS(0.925)PT(0.074)R;AGGPTTPLS(0.879)PT(0.121)R 154.23 0.00044769 192321000.0 3650.6000000000004 3459.0 4758.7 4397.7 4455.5 4412.4 3915.1000000000004 3719.3 2781.6 3643.3 True False 3735.6518771689407 3054.0186719545254 4112.494677668026 3629.7242500529946 4052.500811682417 4368.015262138653 3619.780854934906 3620.652082010955 4720.172039974101 4110.953043747235 0.9087070169412108 0.7428979702406701 1.000375006453342 0.8829398466552203 0.985781342807181 1.0625310519618827 0.8805210899795116 0.8807330182274817 1.1481941023757225 1.0 12.005257177862918 -5.2751731583868535 24.78154049211799 0.9719904587279681 0.8258024888493541 0.3212534913429508 0.08910478974874535 726.2858087572733 1310526.6089359287 0.0227744507047155 0.04782183073472107 5.306728164668335e-06 5.2751731583868535 -0.14618796987861393 AGGPTTPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 3 AGGPTTPLSPTR 12 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 AGGPTTPLS(0.987)PT(0.013)R;AGGPTT(0.007)PLS(0.992)PT(0.001)R;AGGPTTPLS(0.978)PT(0.022)R 157.5 0.00044524 215647000.0 328711.0 261293.0 353177.0 318727.0 401999.0 281384.0 306592.0 291412.0 245333.0 280247.0 True False 310442.55855439184 281333.3329105837 330453.9763300429 275315.83276525716 351496.29170334246 320142.0918503678 320849.1355005225 292259.9606741464 294406.45517675695 272155.5409408479 1.1406806471078446 1.0337225982539542 1.2142099888455549 1.0116120796713677 1.2915272292021385 1.1763203157416133 1.178918255315838 1.0738710652878758 1.0817580790712074 1.0 18.054071883296096 -8.33368741955778 1.5037709759285847 1.0076385546308506 1.1472613332237982 0.25450717731431227 0.07844747659322521 0.5344438137214934 2.4312097638197825 0.07314918975288154 0.022083635302890543 4.6378060251204074e-09 8.33368741955778 0.13962277859294758 AGGS(ph)PASYHGSTSPR ddPTM_A459_Selumetinib_30min_R1 1 AGGSPASYHGSTSPR 15 0 I3L2B2;O95208-3;O95208-2;F6PQP6 I3L2B2 EPN2 Epsin-2 1 AGGS(0.871)PAS(0.064)YHGS(0.032)T(0.025)S(0.008)PR 106.55 0.0044575000000000005 704570.0 210.59 227.73 177.15 334.29 331.15 247.97 124.81 331.07 0.0 0.0 True False 215.49633726319158 201.0672657311953 153.09400301529632 275.912526900474 301.197540969281 245.47564693874585 115.39548121489253 322.2889481330805 0.0 0.0 0.0 AGGS(ph)PASYHGSTSPR ddPTM_A459_Selumetinib_30min_R2 2 AGGSPASYHGSTSPR 15 0 I3L2B2;O95208-3;O95208-2;F6PQP6 I3L2B2 EPN2 Epsin-2 1 AGGS(0.999)PAS(0.001)YHGSTSPR;AGGS(0.99)PAS(0.01)YHGSTSPR 83.964 0.014875 28603000.0 9709.0 10745.0 25357.0 33391.0 56270.0 18815.9 12727.7 17903.9 26622.0 30241.0 True False 9169.412648206437 11569.106949379495 23725.55822661412 28843.08819731214 49200.859539817444 21407.619431265954 13319.563269459088 17955.99738484981 31947.143880829874 29367.86375444591 0.31222606876941494 0.39393764034430606 0.8078748398246155 0.9821309591490349 1.6753298759215702 0.7289471107010677 0.45354212280566986 0.6114165311779447 1.0878266171468973 1.0 14.841950706058102 -5.286597523282982 3.0973938703403743 0.9191312154766904 0.32511589994770085 0.35399176648348696 0.3097764315585264 0.31561054248459497 6.105108211797455 0.09277380931395086 0.2582524695875458 5.1689517319986174e-06 5.286597523282982 -0.5940153155289896 AGGS(ph)VESLR ddPTM_A459_Selumetinib_30min_R1 1 AGGSVESLR 9 0 O94885 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 AGGS(0.999)VES(0.001)LR 97.597 0.02045 6108200.0 1657.2 1574.6 1608.4 1780.0 1563.6 1321.7 1715.3 1469.0 835.42 1145.5 True False 1695.8095356501303 1390.2450999883188 1389.988114308793 1469.1564147382333 1422.1726560760017 1308.4048980075834 1585.9135400040461 1430.037348015512 1417.6467233373464 1292.5360831148837 1.3120016979049418 1.0755948078741184 1.0753959850459722 1.1366463450658275 1.1002962893296617 1.0122772703215042 1.2269781561394804 1.1063809874996013 1.0967946983119872 1.0 10.335988840795544 -1.5229181011725148 0.013524113447281237 1.4726163631845366e-06 2.4298464293899293 0.2403249700653729 0.0776313501670044 12355.646454335543 12.955561948649374 951.7202187104692 1419.0556007403306 0.02999728151445737 1.5229181011725148 2.4298449567735663 AGGSAALS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 AGGSAALSPSK 11 0 Q92522 Q92522 H1FX Histone H1x 1 AGGSAALS(0.999)PS(0.001)K;AGGS(0.001)AALS(0.993)PS(0.006)K;AGGSAALS(0.999)PS(0.001)K 153.49 0.00055963 1419590000.0 27764.1 41435.0 37805.0 41022.0 30234.3 28907.0 28623.4 26208.199999999997 17131.199999999997 24661.7 True False 28410.949510465733 36583.77093739111 32671.288648000424 33858.27777830998 27499.6129032992 28616.221825455985 26464.313893168463 25513.073399768633 29070.39518665669 27827.269420300603 1.0209751119072905 1.314673401289688 1.1740745437339246 1.2167301529631802 0.9882253442818083 1.0283517722576052 0.9510208671017562 0.9168371145016581 1.044672933861387 1.0 14.764211729215617 -6.266744454100938 24.125692859406488 0.9841766773336894 1.1905791170432156 0.6121293169585995 0.07525498003483558 167.17273907910075 760243.7354950644 0.022144345827166474 0.025872289361009257 5.410726051694146e-07 6.266744454100938 0.2064024397095262 AGGSAALS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 5 AGGSAALSPSK 11 0 Q92522 Q92522 H1FX Histone H1x 1 AGGSAALS(1)PSK;AGGSAALS(0.98)PS(0.02)K;AGGSAALS(0.997)PS(0.003)K;AGGSAALS(0.999)PS(0.001)K;AGGSAALS(0.983)PS(0.017)K 161.25 0.00060989 2116007000.0 1664133.0 1806729.0 1859153.0 1805530.0 1649331.0 1209206.0 1445037.0 1504490.0 1162648.0 1927046.0 True False 1571647.1499122188 1945299.3047506216 1739537.120072733 1559613.6992870248 1442127.2945737788 1375763.150420834 1512234.0837864939 1508867.8168182713 1395210.087099358 1871407.1749131924 0.8398210560377496 1.0394847956275772 0.9295342795473804 0.8333908943997553 0.7706111817385084 0.7351490198730539 0.8080732531425935 0.8062744639676088 0.7455406315646281 1.0 20.83569205912569 -5.805467200684841 3.468557361785465 0.7978359034770188 0.9495627309010406 0.30663874022121573 0.08292551179009681 0.22617644345894738 5.581892739713355 0.022434643312378412 0.03698381952364182 1.5650665136150622e-06 5.805467200684841 0.15172682742402177 AGGSAALS(ph)PSKK ddPTM_A459_Selumetinib_30min_R2 1 AGGSAALSPSKK 12 1 Q92522 Q92522 H1FX Histone H1x 1 AGGSAALS(0.5)PS(0.5)KK 75.02 0.025902 374000000.0 3756500.0 3322100.0 2915800.0 3045300.0 3241100.0 2294000.0 2806800.0 2654600.0 2074000.0 3573900.0 True False 3547728.768460964 3576894.387764881 2728200.6024830057 2630524.886564487 2833924.0421983697 2609977.6771413577 2937321.7615686893 2662324.4465073114 2488857.9524018136 3470712.220892634 1.0221904158762325 1.0305937686890496 0.7860636171619376 0.7579207722062135 0.8165252149512735 0.752000601326173 0.8463167138683825 0.7670830299559055 0.7171029442947313 1.0 21.726800316310637 -5.26067910449074 24.982061928738165 0.7953173177687652 1.02639211548619 0.5832969174815379 0.07433448555415281 38.24243773189258 1256557.6814943375 0.01769900857938189 0.04158582137613405 5.486822305623996e-06 5.26067910449074 0.23107479771742467 AGGSAALSPS(ph)KK ddPTM_A459_Selumetinib_30min_R2 2 AGGSAALSPSKK 12 1 Q92522 Q92522 H1FX Histone H1x 1 AGGS(0.292)AALS(0.203)PS(0.505)KK;AGGSAALS(0.072)PS(0.927)KK 147.52 0.0011265999999999995 108267000.0 327760.0 333990.0 285900.0 334770.0 284950.0 195537.0 264710.0 239220.0 169788.0 311630.0 True False 309544.4113272369 359605.9590528857 267505.50526438403 289173.7484895392 249152.03351467906 222470.4468418438 277019.5395129138 239916.09059499716 203750.34427309484 302632.4321880224 1.0228395188487933 1.1882598188599502 0.8839287426345158 0.9555279531635873 0.8232826591430341 0.7351176647968292 0.9153663323856989 0.7927639772790107 0.6732601089710929 1.0 18.207207079471893 -5.606921183702643 1.3231765974159138 0.815505243120111 1.1114474509822454 0.48765813500022737 0.10316531453164014 0.38715667159312767 1.2830253436849697 0.032869355050486444 0.1025233652867158 2.472172757263717e-06 5.606921183702643 0.29594220786213443 AGGSPAPGPETPAIS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 1 AGGSPAPGPETPAISPSKR 19 1 P33316;H0YKI0 P33316 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 AGGSPAPGPET(0.05)PAIS(0.922)PS(0.029)KR 113.28 0.00096507 4334100.0 830.17 937.75 1093.7 818.5 807.59 886.18 545.6 716.32 494.34 577.06 True False 849.5113457703768 827.9577940518523 945.1815472640675 675.5643401478894 734.5436270915953 877.2658337870614 504.44495273491975 697.3208666647187 838.8588748349134 651.1312720403974 1.3046698603621536 1.271568160836981 1.451599067423422 1.0375240280365094 1.128103745946367 1.3472948873090436 0.7747208195886236 1.070937453947774 1.288309916687382 1.0 9.346804618618426 -5.770169664336749 24.99783282078568 1.094238709960778 1.3355079520052338 0.3573525830582862 0.15365433321931124 211.15700786785317 604616.7274336973 0.04376016714354728 0.0660445401490078 1.6975803350109915e-06 5.770169664336749 0.24126924204445577 AGGSPAPGPETPAIS(ph)PSKR ddPTM_A459_Selumetinib_30min_R2 3 AGGSPAPGPETPAISPSKR 19 1 P33316;H0YKI0 P33316 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 AGGSPAPGPET(0.068)PAIS(0.741)PS(0.191)KR;AGGSPAPGPET(0.107)PAIS(0.725)PS(0.167)KR;AGGSPAPGPET(0.002)PAIS(0.988)PS(0.01)KR 142.23 0.00016641 28529900.0 76958.0 71484.0 78556.0 79480.0 74447.4 57556.5 72019.0 68682.1 51059.6 79193.9 True False 72680.98244728305 76966.59294271232 73501.79248530598 68654.68688935247 65094.65204379957 65484.38542911362 75368.02620294108 68881.95354006632 61272.94672442418 76907.36633653709 0.9450457857214886 1.0007701031643192 0.9557184959847833 0.8926932511110585 0.8464033439781757 0.851470912975515 0.9799844903430961 0.8956483211068161 0.7967110257852463 1.0 16.230834168480634 -5.705100030391927 4.112451574798367 0.8897923493193047 0.9736841568055123 0.24529194589218184 0.05824453730389975 0.2804990083617822 9.604898142916204 0.01616530415496799 0.028340469597188955 1.971968483281481e-06 5.705100030391927 0.08389180748620761 AGHDDVPPLS(ph)PLLPPMQNNQIQR ddPTM_A459_Selumetinib_30min_R1 2 AGHDDVPPLSPLLPPMQNNQIQR 23 0 O14544 O14544 SOCS6 Suppressor of cytokine signaling 6 1 AGHDDVPPLS(1)PLLPPMQNNQIQR;AGHDDVPPLS(1)PLLPPMQNNQIQR 146.75 8.862399999999997e-08 27707000.0 2582.1 2996.21 3542.0 3956.3 3086.96 3091.0 4611.299999999999 4714.1 3384.6 2658.77 True False 2642.2579061080146 2645.41234029976 3061.015854813319 3265.406473948804 2807.745013047054 3059.9073464034486 4263.465928421071 4589.066754445148 5743.418998596615 3000.049028112928 0.8807382417246797 0.8817897026048807 1.020321943451284 1.088451036416158 0.935899709216807 1.0199524466865704 1.4211320843322515 1.5296639193032566 1.914441712377382 1.0 11.550770362729047 -7.3072042821953875 2.8736167944002715 1.5353980160479246 0.9660134545911582 0.5575027617409261 0.21540941944810948 0.1865335896465636 3.0633228177266285 0.09559743181275619 0.06260440219174036 4.9294188082250815e-08 7.3072042821953875 -0.5693845614567664 AGHDDVPPLS(ph)PLLPPMQNNQIQR ddPTM_A459_Selumetinib_30min_R2 4 AGHDDVPPLSPLLPPMQNNQIQR 23 0 O14544 O14544 SOCS6 Suppressor of cytokine signaling 6 1 AGHDDVPPLS(1)PLLPPMQNNQIQR;AGHDDVPPLS(1)PLLPPMQNNQIQR;AGHDDVPPLS(1)PLLPPMQNNQIQR;AGHDDVPPLS(1)PLLPPMQNNQIQR 120.11 7.0238e-06 37090500.0 111893.0 103043.0 129030.0 124852.0 142374.0 96798.0 123756.0 153566.0 168027.0 229722.0 True False 105674.43500316843 110946.06676453337 120728.35027724161 107846.94221828703 124487.70528029093 110131.0458552437 129510.89921786173 154012.85163578021 201637.09506664402 223089.32897056435 0.4736866415386085 0.49731678012789315 0.5411659573065961 0.48342492541414633 0.558017301207251 0.4936634412925013 0.580533814931821 0.6903640454093684 0.9038401612353639 1.0 17.76726198125312 -8.136723220071374 1.3669104693554117 1.003971650896977 0.5084706363208309 0.9793010248374318 0.02543532806800062 0.050144385190177096 0.17223483079935661 0.022720300007664607 0.007323580628134546 7.29922548508175e-09 8.136723220071374 -0.49550101457614604 AGHSENGVEEDTEGR ddPTM_A459_Selumetinib_30min_R1 1 AGHSENGVEEDTEGR 15 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 0 120.29 0.0025419 1399600.0 553.99 859.82 932.5 948.77 594.02 541.05 598.62 584.26 546.85 651.5 False True 566.8968891231086 759.1518746805268 805.8716218558501 783.0851301186481 540.290995882749 535.6075282340947 553.4656114482732 568.7635268560533 927.9645096562539 735.1263711474 0.7711556969970816 1.0326821407530618 1.096235495671349 1.0652387954691287 0.7349634254576556 0.7285924560128454 0.7528849911674546 0.7736949035963923 1.2623197127425427 1.0 9.521848466059003 -4.726134553776315 23.281323673622797 0.9216076531124215 0.7711530084045259 0.06843388865222344 0.17553599747606913 8198.381217979591 5405556.764883084 0.04667141095642378 8.28208257344533 1.878734654199282e-05 4.726134553776315 -0.1504546447078956 AGIIAS(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 1 AGIIAS(1)AR 88.177 0.031435000000000005 4512800.0 23964.0 20366.0 26985.0 25084.0 28394.0 17901.0 16319.0 20023.0 17087.0 23608.0 True False 22632.176815492738 21928.006712988623 25248.8144790465 21667.51592768644 24826.89187441933 20366.70026090125 17077.86583548503 20081.263615013904 20504.877450670134 22926.37569904959 0.9871676671699554 0.956453257193096 1.101299865730334 0.9450912002887863 1.0828964944270945 0.8883523731902181 0.7449003741220638 0.8759022306280347 0.8943793698504279 1.0 14.48472068500114 -6.884897432326061 6.642953171919029 0.8615071659191632 1.0117876368094971 0.440218391385475 0.07440412020678293 0.18320028177255693 9.962095912666737 0.025451726653083484 0.022452239878461656 1.3034745847350335e-07 6.884897432326061 0.15028047089033392 AGISTTSVCEGQIANPS(ph)PISR ddPTM_A459_Selumetinib_30min_R2 2 AGISTTSVCEGQIANPSPISR 21 0 B4DRX9;Q8WU58 B4DRX9 FAM222B Protein FAM222B 1 AGISTTSVCEGQIANPS(0.999)PIS(0.001)R;AGISTTSVCEGQIANPS(0.996)PIS(0.004)R 266.28 6.816199999999996e-114 3337500.0 13933.7 11266.4 13916.1 12951.5 14490.599999999999 14043.2 11713.4 10397.0 9556.6 11720.3 True False 13159.320735020507 12130.496652814252 13020.753276704067 11187.483357416324 12670.161280392354 15977.523328522904 12258.096309661774 10427.253548683992 11468.18703371417 11381.904486003517 1.15616158536585 1.0657703785628574 1.1439872204793025 0.9829184009735562 1.1131846428664924 1.4037653670500119 1.076981126026468 0.9161255536370496 1.0075806775409824 1.0 13.474454357460058 -7.536118494967545 14.882993996220158 0.9764020311020554 1.1409961411095921 0.3525341657324015 0.10289305359764082 2.4951431561366944 2797.232261951135 0.05101666437663191 0.029643715031243037 2.9099230525274742e-08 7.536118494967545 0.16459411000753676 AGLAS(ph)PEEEDAVGKEPLK ddPTM_A459_Selumetinib_30min_R1 2 AGLASPEEEDAVGKEPLK 18 1 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 1 AGLAS(1)PEEEDAVGKEPLK;AGLAS(1)PEEEDAVGKEPLK 143.33 0.0001617 71820000.0 9615.8 10132.0 10830.6 11909.1 9204.3 8391.4 9841.5 9239.2 5180.9 8279.8 True False 9839.829430910288 8945.740729760992 9359.864008227314 9829.399246493867 8371.772690151147 8306.990134781594 9099.147731562898 8994.146402848823 8791.608902035452 9342.592982081722 1.053222531451624 0.9575222582122696 1.0018486330485248 1.0521061192910575 0.8960866331442969 0.8891525244344558 0.9739424321507176 0.9627034400512589 0.941024501323882 1.0 13.189607301750382 -6.259708720881017 24.999910095478533 0.9407263498506291 1.0109621076052082 0.43400438259189356 0.040211899287300866 164.11162390504657 2370646.4248128626 0.0124545063009667 0.015212580634219902 5.499095717786323e-07 6.259708720881017 0.07023575775457913 AGLAS(ph)PEEEDAVGKEPLK ddPTM_A459_Selumetinib_30min_R2 2 AGLASPEEEDAVGKEPLK 18 1 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 1 AGLAS(1)PEEEDAVGKEPLK;AGLAS(1)PEEEDAVGKEPLK 151.38 6.6575e-05 53650000.0 195981.0 183938.0 195603.0 192459.0 214497.0 143774.0 192024.0 181485.0 142624.0 193518.0 True False 185089.16059410316 198045.45314611096 183018.11593644344 166245.75218970692 187549.96923248988 163577.5634495738 200953.49648833758 182013.09130354098 171152.78524752005 187930.63251985272 0.9848802087895416 1.0538220964333196 0.973859947590554 0.8846123165798687 0.9979744478999578 0.8704145846595482 1.0692961216267345 0.9685120986559409 0.9107231905338249 1.0 17.519840718323813 -5.505591279025141 23.441955949573142 0.9565103077638706 1.0179736570845908 0.15123834955537618 0.05790842144572161 568.2213362875435 770509.0813057262 0.014845714284396508 0.02975899989403177 3.1218261989447893e-06 5.505591279025141 0.06146334932072017 AGLCDRCMVT(ph)QELAR ddPTM_A459_Selumetinib_30min_R2 1 AGLCDRCMVTQELAR 15 1 Q8NC74 Q8NC74 RBBP8NL RBBP8 N-terminal-like protein 1 AGLCDRCMVT(1)QELAR 117.48 0.022138 16099000.0 9266.9 5717.2 25638.0 43369.0 44145.0 44333.0 21955.0 41025.0 62533.0 24783.0 True False 8751.882796339913 6155.690856304553 23988.4789925438 37462.067384302085 38599.11043869272 50439.468335095014 22975.951003007165 41144.375957945624 75041.34731800508 24067.450396032953 0.363639797831784 0.25576829930100103 0.9967187465980124 1.5565449089063863 1.6037889266847736 2.0957545359025223 0.9546483164994618 1.7095444378573423 3.1179599867534855 1.0 14.554795696441857 -5.561737081304806 1.7149169783212097 1.7602190738964796 0.24859249939655279 0.501619687039655 0.5687103335678049 0.3204703615666726 1.8376444260706182 0.17308799472669958 0.474073956635436 2.743234403326207e-06 5.561737081304806 -1.5116265744999269 AGLES(ph)GAEPGDGDSDTTKK ddPTM_A459_Selumetinib_30min_R1 1 AGLESGAEPGDGDSDTTKK 19 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLES(1)GAEPGDGDSDTTKK 116.45 0.001178 0.0 2155.9 2659.0 2523.9 3139.1 2218.7 2450.4 2285.2 2281.5 1454.3 1838.3 True False 2206.1282753488513 2347.683043864437 2181.1682427903274 2590.915113204935 2018.018976743301 2425.751200785188 2112.8255241749257 2220.9872086435607 2467.840882130548 2074.263711558351 1.063571745027267 1.131815125908302 1.0515385438390865 1.2490770092383454 0.9728844820927833 1.1694516889382265 1.0185906027289096 1.070735218606789 1.1897430728692209 1.0 11.018383607536386 -6.286140495201504 24.99984695925367 1.076149657781082 1.1193829907745951 0.09131006279013976 0.08130586260070541 2371.6950269249687 2400369.689792128 0.023994726171808867 0.027216479321082326 5.174394121059503e-07 6.286140495201504 0.04323333299351306 AGLES(ph)GAEPGDGDSDTTKK ddPTM_A459_Selumetinib_30min_R2 2 AGLESGAEPGDGDSDTTKK 19 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLES(1)GAEPGDGDSDTTKK;AGLES(1)GAEPGDGDSDTTKK 97.69 0.00078118 23218000.0 93153.0 84846.0 92920.0 93815.0 88352.0 72932.0 83609.0 80611.0 60988.0 87782.0 True False 87975.92918100473 91353.41537711048 86941.62836364638 81037.23516009822 77252.43188309848 82977.72098922136 87496.98416809042 80845.56466413061 73187.30414709829 85247.50557497352 1.0320059054822621 1.0716256711671983 1.019872989564286 0.950611218633577 0.9062134001698909 0.9733741817963703 1.02638761777186 0.9483628185815772 0.8585272220397285 1.0 16.379369999642087 -5.643759500181403 3.6153962391421346 0.9517383945917413 1.0509098305962732 0.46402705492781915 0.04473207840517252 0.20961617207089078 5.222433787464758 0.01306112513267163 0.024041627788473456 2.2711221859928866e-06 5.643759500181403 0.09917143600453193 AGLESGAEPGDGDS(ph)DTTK ddPTM_A459_Selumetinib_30min_R1 6 AGLESGAEPGDGDSDTTK 18 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLES(0.001)GAEPGDGDS(0.843)DT(0.143)T(0.013)K;AGLESGAEPGDGDS(1)DTTK;AGLESGAEPGDGDS(1)DTTK;AGLESGAEPGDGDS(0.858)DT(0.04)T(0.101)K;AGLESGAEPGDGDS(0.999)DT(0.001)TK;AGLESGAEPGDGDS(0.999)DT(0.001)TK 304.2 5.436999999999998e-96 294203000.0 33361.78 42001.42 40980.85 43913.06999999999 33121.64 38580.0 37195.560000000005 35201.71 21951.629999999997 34766.41 True False 34139.04456327651 37083.87422046957 35415.87566169577 36244.47667491518 30125.7935101005 38191.92022783727 34389.868962882865 34268.046299531066 37250.31282637928 39229.017377011034 0.8702498009364531 0.9453174384684293 0.902797929433995 0.9239200749431759 0.7679466763231954 0.9735630097688471 0.8766436495815977 0.8735382273330355 0.9495601806281462 1.0 15.25963357825613 -8.503628030377328 3.742545510290528 0.9996811509667779 0.8933296074909169 0.3104845876726411 0.0521036592181833 0.2320882549577042 8.286541059980257 0.048435847863011056 0.0127423305457675 3.1359705071409063e-09 8.503628030377328 -0.10635154347586095 AGLESGAEPGDGDS(ph)DTTK ddPTM_A459_Selumetinib_30min_R2 4 AGLESGAEPGDGDSDTTK 18 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLESGAEPGDGDS(0.986)DT(0.01)T(0.003)K;AGLESGAEPGDGDS(0.997)DT(0.003)TK;AGLESGAEPGDGDS(0.998)DT(0.001)TK;AGLESGAEPGDGDS(0.851)DT(0.132)T(0.017)K 284.07 2.3225999999999994e-67 417655000.0 770927.0 698071.0 674845.0 725250.0 670800.0 531524.0 685978.0 678493.0 527368.0 615832.0 True False 728081.963605298 751610.8010479555 631426.207415682 626469.6988739679 586528.106971913 604736.6063055288 717877.3362396205 680467.3022994379 632856.3358930758 598051.3300363069 1.2174238682172935 1.2567663732180419 1.0558060415605948 1.047518277128379 0.9807320501006255 1.0111784322406172 1.2003607385941923 1.1378075227391062 1.0581973554923052 1.0 19.18990978897854 -5.263346894402757 24.850992221613502 1.0661570773604092 1.2370951319206338 0.5569057412180745 0.06255643860769912 116.94190068547327 1523537.25728091 0.01797204065450912 0.04075298532458807 5.453221089343706e-06 5.263346894402757 0.1709380545602246 AGLESGAEPGDGDS(ph)DTTKK ddPTM_A459_Selumetinib_30min_R1 1 AGLESGAEPGDGDSDTTKK 19 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLESGAEPGDGDS(0.878)DT(0.024)T(0.099)KK 88.62700000000002 0.0092526 0.0 1761.0 2287.2 2639.8 2376.6 1847.8 2353.3 1422.5 1877.3 1098.3 1456.0 True False 1802.0278736904897 2019.413560709567 2281.329659383455 1961.5714243072384 1680.6668162555868 2329.6279386254423 1315.199679738679 1827.5079056701961 1863.7348833418016 1642.8917826410047 1.0968634043525791 1.2291823369298802 1.3886061659619109 1.1939748223427993 1.0229930139122476 1.4180044986776217 0.8005394473544998 1.1123726620218495 1.1344234008802356 1.0 10.682021737689565 -7.25715288478049 24.989934298245174 1.0211982707730742 1.221983130457703 0.3605946745918932 0.13876179283997148 444.1974269298547 2589647.7322700745 0.054313692626228725 0.04057578630188936 5.5315534753999653e-08 7.25715288478049 0.20078485968462867 AGLESGAEPGDGDS(ph)DTTKK ddPTM_A459_Selumetinib_30min_R2 2 AGLESGAEPGDGDSDTTKK 19 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLESGAEPGDGDS(0.56)DT(0.22)T(0.22)KK;AGLESGAEPGDGDS(0.779)DT(0.173)T(0.048)KK 74.214 0.0051416000000000005 82895000.0 45986.0 46089.0 45247.0 39169.0 40292.4 32787.0 42682.0 39275.0 28306.5 37533.0 True False 43430.28221654356 49623.87810050733 42335.85728120873 33834.114629706186 35230.50849337374 37303.111639247494 44666.7975727785 39389.28374767373 33968.590949692385 36449.3247675546 1.19152501434548 1.3614484881947682 1.1614990826632277 0.9282507932718593 0.9665613483390015 1.0234239420658044 1.2254492465259244 1.0806588050359753 0.931940198242837 1.0 15.153604468079067 -5.5320489231950205 6.355464471332282 1.0322258664325505 1.2739683730158207 0.5680698649065961 0.08972044785762726 0.10785387585217891 18.995141772713815 0.025854227025712558 0.04761112889228096 2.9373187448969796e-06 5.5320489231950205 0.24174250658327012 AGLESGAEPGDGDS(ph)DTTKKK ddPTM_A459_Selumetinib_30min_R1 1 AGLESGAEPGDGDSDTTKKK 20 2 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLESGAEPGDGDS(0.518)DT(0.241)T(0.241)KKK 83.727 0.0031605 22324000.0 1344.6 788.41 5399.0 5134.2 2522.5 2156.4 1396.8 1887.8 1644.7 1209.1 True False 1375.926563863845 696.1025906781349 4665.845454584162 4237.608350870244 2294.3403203835464 2134.708573854545 1291.438251429868 1837.7294115613895 2790.9357758647543 1364.2997626313456 1.0085221749288256 0.510227011500428 3.419956216649247 3.1060683780352676 1.6816981012724195 1.5646917432114043 0.9465942066419857 1.3470129233306711 2.045691022097544 1.0 10.413944951419841 -6.654367773351214 3.7156525182317908 1.37149931443946 2.0390289242614896 0.1042782159026584 0.8536576466335967 0.5952983964870614 15.67344076896791 0.326406166267847 0.3227337447925191 2.2163187809090177e-07 6.654367773351214 0.6675296098220296 AGLESGAEPGDGDSDT(ph)TKK ddPTM_A459_Selumetinib_30min_R1 2 AGLESGAEPGDGDSDTTKK 19 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AGLESGAEPGDGDS(0.19)DT(0.572)T(0.238)KK;AGLESGAEPGDGDS(0.266)DT(0.599)T(0.134)KK 139.16 0.00017032 153184000.0 11196.0 13415.6 15075.6 14731.300000000001 10212.3 12479.599999999999 10801.0 10453.400000000001 7149.5 10770.9 True False 11456.84501637634 11844.89531525676 13028.416324343218 12158.75499574906 9288.599268127999 12354.066554570198 9986.271874065016 10176.141874571373 12132.179321180187 12153.449932450543 0.9426825370618246 0.9746117671189048 1.071993252677699 1.0004365067802148 0.764276754317044 1.0165069690692512 0.8216820680193027 0.837304792559385 0.9982498293580359 1.0 13.569078281359584 -6.082662024739289 24.999999951256793 0.8979210661084452 1.0012523564257154 0.21479135453818654 0.08428554354612594 124.52990372324659 37660.77385129166 0.02396251472479163 0.030935483343508798 8.266810363826149e-07 6.082662024739289 0.10333129031727017 AGLGS(ph)PERPPK ddPTM_A459_Selumetinib_30min_R1 1 AGLGSPERPPK 11 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 AGLGS(1)PERPPK 151.13 0.0028548 201750000.0 4373.5 4592.7 5510.9 4970.2 4942.3 4561.5 4442.9 4578.2 2488.1 3844.0 True False 4475.394040650402 4054.9845489116938 4762.550049206866 4102.247872208967 4495.269837633935 4515.615451510623 4107.768476000686 4456.771263910561 4222.12397636596 4337.414843730782 1.0318113903997566 0.934885108988985 1.0980158045271058 0.9457817663298402 1.0363937966716081 1.041084520203874 0.9470545529990005 1.0275178705473134 0.9734194510973601 1.0 12.082619718264619 -7.23776528673333 24.94102548827244 0.9892911037891244 1.0126815239697586 0.07183354850587742 0.04812125986105397 2574.637662518897 2712423.858902034 0.017392884283402278 0.013464511722992343 5.784085622770341e-08 7.23776528673333 0.023390420180634197 AGLLNTS(ph)GTK ddPTM_A459_Selumetinib_30min_R2 2 AGLLNTSGTK 10 0 A0A087WT26;H3BQD9;Q08AM6 A0A087WT26 VAC14 Protein VAC14 homolog 1 AGLLNT(0.006)S(0.964)GT(0.031)K;AGLLNT(0.021)S(0.968)GT(0.012)K 120.57 0.0050461 11220800.0 151751.0 140126.0 134234.0 158836.0 145461.0 126243.0 139068.0 140029.0 108232.0 139434.0 True False 143317.28692738453 150873.2136238947 125597.53058292856 137202.2627926168 127186.88874216082 143631.8273301467 145534.93755801432 140436.46120695097 129881.4242547511 135408.17812696012 1.0584093878953806 1.1142104982937915 0.9275475995634991 1.0132494557601575 0.939285134040494 1.060732293403106 1.074786911478561 1.0371342643372417 0.9591844898243362 1.0 17.046955349146685 -5.236000437496532 24.997556187296464 1.0057481519004008 1.0863099509700238 0.3295667304754034 0.04808505717628953 973.6354108108217 956738.9355628086 0.01271898049233546 0.03362374775172664 5.807638324752172e-06 5.236000437496532 0.08056179906962302 AGLQMKS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 AGLQMKSPEK 10 1 Q9BRQ0 Q9BRQ0 PYGO2 Pygopus homolog 2 1 AGLQMKS(1)PEK 149.23 0.0035907 32345000.0 1681.1 1892.7 2963.3 2961.4 2539.7 3612.0 2240.7 2230.4 3129.3 1788.0 True False 1720.2663591488256 1671.1018041076422 2560.9001362417603 2444.247082362812 2309.9845834204543 3575.666559433599 2071.682195002081 2171.242546639753 5310.193544970863 2017.5072165948607 0.852669246979093 0.8283002857992846 1.269338773699177 1.2115183838044459 1.144969675657089 1.7723190926021035 1.026852433518754 1.0762006345158786 2.6320567784304547 1.0 10.978358118674187 -5.119023766842302 0.49409301997773675 1.5157779152697013 0.4515140562109783 0.20529035692578945 0.46013010337762345 5.62418775795511 1.3474215673695311 0.30855184247758805 3.350944542649049 7.602846690887655e-06 5.119023766842302 -1.064263859058723 AGLQS(ph)LEASGR ddPTM_A459_Selumetinib_30min_R1 3 AGLQSLEASGR 11 0 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 AGLQS(1)LEASGR;AGLQS(1)LEASGR;AGLQS(1)LEASGR 167.22 0.00054941 36126100.0 2942.5099999999998 3590.7 2929.1 2785.34 2844.48 2808.05 3061.5199999999995 2871.26 2015.37 2995.73 True False 3011.064757872234 3170.299174728856 2531.344308394606 2298.932656307297 2587.197286233734 2779.803566505404 2830.587081556105 2795.104857633097 3419.9356931990956 3380.2611263812764 0.8907787432078409 0.9378858781016145 0.7488605802192937 0.6801050482062636 0.7653838533484679 0.8223635578950997 0.8373871058258678 0.8268902173913955 1.0117371307524672 1.0 11.722918984182517 -8.236771820147778 4.676353790339333 1.0092521975586344 0.8095629757093175 0.5590584557576329 0.06827301457454804 0.1535826522346487 8.73294227057729 0.06178795519653063 0.019883207520731746 5.797332102965181e-09 8.236771820147778 -0.19968922184931692 AGLQS(ph)LEASGR ddPTM_A459_Selumetinib_30min_R2 2 AGLQSLEASGR 11 0 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 AGLQS(1)LEASGR;AGLQS(1)LEASGR 147.7 0.00066196 11741300.0 30410.0 20257.4 35509.0 26619.0 31458.0 18319.0 29252.0 21838.0 18679.0 23266.0 True False 28719.93394087525 21811.077442192676 33224.389599275986 22993.446279663756 27505.9648019118 20842.275966675053 30612.275961738353 21901.544964524488 22415.321934866708 22594.250127672316 1.271116933670682 0.9653375225531186 1.47047985268537 1.0176680416360675 1.217387815328461 0.9224592915853609 1.3548701899270361 0.969341528962741 0.9920808085333859 1.0 14.46366805627332 -7.842790094725397 24.99999999536883 0.9855291114240868 1.1635271056834955 0.2155307147227642 0.1626319240564081 46.9239658448344 14416.310159565428 0.08273704748557129 0.03974559832035084 1.4361834086283241e-08 7.842790094725397 0.17799799425940865 AGLQSLEAS(ph)GR ddPTM_A459_Selumetinib_30min_R2 2 AGLQSLEASGR 11 0 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 AGLQSLEAS(1)GR;AGLQSLEAS(1)GR 116.98 0.0057309 24026000.0 57614.0 29327.0 40168.0 49796.0 52358.0 46386.0 60175.0 55742.0 55584.0 35871.0 True False 54412.044527115664 31576.286598832256 37583.63461161164 43013.69889710867 45780.31995354115 52775.25044981655 62973.25673450041 55904.19999141514 66702.35314672258 34835.31102594918 1.5619795811951722 0.9064448018078769 1.0788947623753153 1.234772925238627 1.3141929440342563 1.5149929452475313 1.8077420548245138 1.6048141482007015 1.9147913764006677 1.0 15.088262823954896 -6.684096919957482 2.0957092918832334 1.6351530330805117 1.1677984288610679 0.28726890151148343 0.274040083400474 0.3339176233841814 3.0096134862485155 0.1006307662157372 0.0975004796264856 2.0696794142427227e-07 6.684096919957482 -0.46735460421944386 AGLREGS(ph)EEK ddPTM_A459_Selumetinib_30min_R1 1 AGLREGSEEK 10 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 AGLREGS(1)EEK 127.87 0.015258 19745000.0 3901.1 4217.2 4644.2 5163.8 4376.3 3942.1 3255.2 4436.1 2393.2 3187.8 True False 3991.988039780791 3723.448263476908 4013.543148764545 4262.039266531064 3980.4644376985207 3902.4460531404184 3009.657643223443 4318.440217516411 4061.0856075877227 3596.985181801508 1.1098149806059112 1.035158076912639 1.1158075293361116 1.184892083541048 1.1066112971043576 1.0849213593885099 0.8367167200049712 1.2005721456304612 1.1290248367255644 1.0 11.812572500797733 -7.008911605510338 24.976401017587087 1.0443679639394996 1.1092121269259807 0.10693533583664316 0.09376362464053509 1136.5112274621029 3185282.535119131 0.03545596686139616 0.029719781527814123 9.796893670099297e-08 7.008911605510338 0.0648441629864811 AGLS(ph)PAEPLLSR ddPTM_A459_Selumetinib_30min_R1 1 AGLSPAEPLLSR 12 0 O95402;B8ZZF3 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 AGLS(1)PAEPLLSR 116.71 0.004944 8861800.0 2203.1 2876.4 3732.2 3514.0 2949.4 2530.1 2977.5 2671.0 1584.9 2390.5 True False 2254.42794351364 2539.6297507979193 3225.3877395071354 2900.3458659495222 2682.627290758864 2504.649491146997 2752.9047778009985 2600.156403369253 2689.459543483948 2697.343960441843 0.8357954997865195 0.9415298115639322 1.1957643470055614 1.0752599254988697 0.994544014445763 0.928561402579417 1.0205983434719441 0.963969164297211 0.997076970133018 1.0 11.397323787838564 -9.081336499300747 15.33123123507637 0.9999999999921633 0.9993978072129627 0.0 0.0901003286029245 0.0 0.0 0.09276742449837606 0.022499405293585274 8.292080330086815e-10 9.081336499300747 -0.0006021927792005943 AGLS(ph)PAEPLLSR ddPTM_A459_Selumetinib_30min_R2 2 AGLSPAEPLLSR 12 0 O95402;B8ZZF3 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 AGLS(1)PAEPLLSR;AGLS(1)PAEPLLSR 128.57 0.002433 5372800.0 39220.0 37761.0 39826.0 44466.0 45641.0 30890.0 38237.0 39876.0 35885.0 38377.0 True False 37040.30941009956 40657.14727924792 37263.638519270185 38409.65409187154 39907.16954428302 35144.817108498966 40015.09626517809 39992.03255817284 43063.002710674635 37268.95629457921 0.9938649506932151 1.0909118827446616 0.9998573135435563 1.0306071838523216 1.0707884929443954 0.943005133567714 1.0736843808797054 1.0730655358864907 1.155465754669877 1.0 15.185686796960228 -7.494043163803191 24.583034975054606 1.0832344193330248 1.0248316325549454 0.2009458584602819 0.05199899803247002 837.6225623866854 714095.7260116579 0.020802350698556196 0.013991820186654253 3.205950674587768e-08 7.494043163803191 -0.05840278677807942 AGLS(ph)PANCQSDR ddPTM_A459_Selumetinib_30min_R1 4 AGLSPANCQSDR 12 0 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 1 AGLS(1)PANCQSDR;AGLS(1)PANCQSDR;AGLS(1)PANCQSDR;AGLS(1)PANCQSDR 201.08 8.4836e-05 92808600.0 10314.2 12860.599999999999 10618.0 10421.1 10881.2 9192.7 10543.1 9722.1 5804.43 9388.4 True False 10554.500792060448 11354.874973269269 9176.133920499107 8601.250513274492 9896.997381231899 9100.229784303785 9747.825478701492 9464.238326168557 9849.69377120609 10593.492590760166 0.9963192687996282 1.0718726497409545 0.86620478014047 0.8119371812065698 0.9342525419675317 0.8590396138324737 0.9201710762703247 0.8934011370738518 0.9297871959430234 1.0 13.370890692454894 -5.263659431439277 24.997427549147137 0.8951136455764636 1.0340959642923493 0.5124702558904708 0.0512597382965866 129.96128719468055 1463361.5167093812 0.01277347553250426 0.028812248272073834 5.449298128033197e-06 5.263659431439277 0.13898231871588573 AGLS(ph)PANCQSDR ddPTM_A459_Selumetinib_30min_R2 6 AGLSPANCQSDR 12 0 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 1 AGLS(0.999)PANCQS(0.001)DR;AGLS(0.999)PANCQS(0.001)DR;AGLS(0.833)PANCQS(0.167)DR;AGLS(1)PANCQSDR;AGLS(1)PANCQSDR;AGLS(0.949)PANCQS(0.051)DR 148.62 0.00059809 172000100.0 85119.0 83714.0 94722.0 89339.0 96358.0 77482.0 78376.0 78592.0 78559.0 90341.0 True False 80388.42673835448 90134.59461706418 88627.68964551577 77170.87408162872 84252.64658855033 88154.44218843374 82020.6392990977 78820.68970839395 94272.99512185852 87732.62059589289 0.9162889036295102 1.0273783457607528 1.0102022377029598 0.8796143732795483 0.9603343205331601 1.0048080359355023 0.9348933012829371 0.8984194154127874 1.0745489474900265 1.0 16.420825742420867 -8.270949345418433 24.993715336746636 1.0372744724944987 0.9571015799009268 0.3108591944678285 0.04942710130669317 950.8112030985569 2498855.8823854835 0.045968959174146624 0.012503947914723958 5.3585915459648036e-09 8.270949345418433 -0.08017289259357185 AGLS(ph)WSAPER ddPTM_A459_Selumetinib_30min_R1 1 AGLSWSAPER 10 0 Q9UMX3 Q9UMX3 BOK Bcl-2-related ovarian killer protein 1 AGLS(0.843)WS(0.157)APER 84.81700000000002 0.037337 6272300.0 4561.6 3124.2 3149.5 3163.1 3402.7 2649.2 2710.5 3012.7 2037.6 2476.3 True False 4667.876404671516 2758.4172115988245 2721.815198965147 2610.7239637407342 3094.9263857954784 2622.5514532811444 2506.04480276393 2932.793409371225 3457.658379584134 2794.157226204616 1.6705847333480321 0.9872090180643348 0.9741095359412779 0.9343511307296603 1.1076421744525113 0.9385840670259745 0.8968875406370609 1.0496164574657534 1.2374602070194778 1.0 11.448197487615538 -4.760310197343681 24.99999258537456 1.0087115652209164 1.6705855210723737 0.8142221606894773 0.09406059205774527 11.705337083303093 259040.9375545235 0.023934398469874055 0.1432510011553624 1.7365600376377747e-05 4.760310197343681 0.6618739558514573 AGLVGPEFHEK ddPTM_A459_Selumetinib_30min_R2 1 AGLVGPEFHEK 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 95.618 0.029568 3711400.0 48722.0 38791.0 45324.0 53623.0 51222.0 36981.0 36019.0 39166.0 31852.0 43224.0 False True 46014.22628961935 41766.14496727593 42407.90318503997 46319.45489516543 44787.03442950998 42074.79706990609 37693.95487029447 39279.96657571964 38223.29001923949 41976.01081056084 1.0962029359407952 0.9950003385449838 1.0102890285698725 1.103474436963691 1.0669673836238367 1.0023533979870332 0.8979880208342943 0.935771785294021 0.9105984413750629 1.0 15.357277446196566 -7.038277433308953 4.1231694144363935 0.9314347814418642 1.0506945541854282 0.654998551806641 0.04029901475883896 0.1374827319275876 5.09011001150347 0.015834307800585413 0.01261349058457117 9.156353827349318e-08 7.038277433308953 0.11925977274356403 AGLY(ph)S(ph)DVYKTT(ph)DPK ddPTM_A459_Selumetinib_30min_R2 1 AGLYSDVYKTTDPK 14 1 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 3 AGLY(0.999)S(1)DVY(0.001)KT(0.001)T(0.999)DPK 90.561 0.038545 11145000.0 48028.0 36863.0 46232.0 53608.0 48968.0 56260.0 49209.0 49654.0 33639.0 32778.0 True False 45358.79603131719 39690.273566773045 43257.483453595654 46306.49792104188 42816.20206052569 64009.304322568794 51497.31600578367 49798.48491933782 40367.739952191296 31831.613972528303 1.4249606089865026 1.2468822222155314 1.3589472243200813 1.4547329570220933 1.3450842328471764 2.0108720964576556 1.6178041129245755 1.5644348088135116 1.268165038286464 1.0 14.958172687988284 AGMS(ph)SNQSISSPVLDAVPR ddPTM_A459_Selumetinib_30min_R1 1 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMS(0.619)S(0.078)NQS(0.014)IS(0.028)S(0.262)PVLDAVPR 104.2 0.02123 0.0 1289.4 1248.5 1036.6 1247.7 1280.2 1218.5 1223.8 1199.3 845.49 974.86 True False 1319.440511264348 1102.3250395880968 895.8354136362188 1029.8126172297154 1164.4061360376681 1206.2429963094805 1131.4877807129674 1167.4906681245766 1434.7347778536457 1099.9927769405288 1.1994992502897897 1.0021202526929813 0.8144011782766937 0.9361994358671979 1.0585579836953982 1.0965917427789584 1.0286320096210426 1.0613621221875507 1.3043129081666822 1.0 10.103278335042665 -6.455487202022798 4.4032448435755285 1.096307376046119 0.9772587384761856 0.16210120810983064 0.11690378420550256 0.4115169820722869 15.490083486451017 0.03910429536378409 0.04359367351890087 3.5035861266823553e-07 6.455487202022798 -0.11904863756993345 AGMS(ph)SNQSISSPVLDAVPR ddPTM_A459_Selumetinib_30min_R2 1 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMS(0.394)S(0.394)NQS(0.175)IS(0.016)S(0.021)PVLDAVPR 101.39 0.0044975 53358000.0 19129.0 14038.0 17182.0 15788.0 18433.0 12836.0 17159.0 17140.0 15894.0 17750.0 True False 18065.886759454224 15114.669460715615 16076.528826347114 13637.647164180897 16117.281746889186 14604.042486393404 17956.92749991347 17189.874562320245 19073.24411546502 17237.51137996146 1.0480565530158692 0.8768475406656648 0.9326479021232739 0.7911610245568632 0.9350121018992025 0.8472245305300015 1.0417354978972386 0.9972364446008957 1.1064963900553297 1.0 14.073263883735901 -7.274816515223008 24.43295252536446 1.0361368051370585 0.9012962519773331 0.46670558108773363 0.06863705758513589 515.6953720555978 941898.3762186291 0.027785024427197574 0.0188602967834689 5.311087846221107e-08 7.274816515223008 -0.13484055315972543 AGMSSNQS(ph)ISS(ph)PVLDAVPR ddPTM_A459_Selumetinib_30min_R2 1 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AGMS(0.001)S(0.002)NQS(0.888)IS(0.132)S(0.977)PVLDAVPR 122.13 0.043138 0.0 9434.9 7304.0 8653.4 11074.0 8578.6 7812.9 8554.8 7826.2 8397.2 9112.2 True False 8910.5460288972 7864.193313938374 8096.64966510954 9565.702096284465 7500.879574342948 8889.056056555242 8952.61515101461 7848.97294630284 10076.874637371522 8849.107109661123 1.0069429512463468 0.8886990762438103 0.9149679809243039 1.080979355062952 0.8476425340307803 1.004514460769777 1.0116970040107753 0.8869790871593842 1.13874479227062 1.0 13.111316176755915 -8.261288612045155 24.999999999326757 1.069372392979336 0.9558589258313556 0.2709450747717298 0.07484166870654428 17.033021210698504 2825784.1386497985 0.05545293097441293 0.017937006359717116 5.479127264257352e-09 8.261288612045155 -0.11351346714798038 AGMSSNQS(ph)ISSPVLDAVPR ddPTM_A459_Selumetinib_30min_R1 4 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMS(0.001)SNQS(0.546)IS(0.302)S(0.152)PVLDAVPR;AGMSS(0.006)NQS(0.813)IS(0.066)S(0.114)PVLDAVPR;AGMS(0.001)SNQS(0.68)IS(0.314)S(0.005)PVLDAVPR;AGMS(0.033)S(0.102)NQS(0.471)IS(0.098)S(0.295)PVLDAVPR 152.59 6.1055e-05 283584000.0 10576.3 12267.5 10614.4 11177.599999999999 11541.1 9252.4 12005.9 11436.7 6417.94 10350.8 True False 10822.70721210263 10831.215396993968 9173.022780725718 9225.641989538244 10497.209542746696 9159.32925650705 11100.285296994463 11133.361564362829 10890.775432208571 11679.426005330024 0.9266471834457942 0.9273756597328527 0.7854001366624966 0.7899054273153517 0.8987778627097075 0.7842276882722744 0.9504135984019023 0.9532456097827073 0.9324752284263332 1.0 13.511681753115639 -7.353478979771142 8.595318820935688 0.955752503072389 0.8518199342450999 0.4874431591968249 0.0537109744686927 0.3376791457505096 28.964974463220486 0.02368263801212469 0.015930720166645502 4.431196613454533e-08 7.353478979771142 -0.10393256882728907 AGMSSNQS(ph)ISSPVLDAVPR ddPTM_A459_Selumetinib_30min_R2 2 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMS(0.001)S(0.007)NQS(0.545)IS(0.336)S(0.11)PVLDAVPR;AGMSS(0.001)NQS(0.464)IS(0.133)S(0.401)PVLDAVPR 111.73 0.0022833000000000003 86889000.0 39642.0 36606.0 41334.0 53204.0 59284.0 36986.0 43879.0 46945.0 37266.0 39181.0 True False 37438.85633949941 39413.56249315828 38674.615441056434 45957.52341798077 51836.21391431557 42080.48577452062 45919.460444589036 47081.60217783685 44720.24129903859 38049.74272553636 0.983945058697415 1.0358430746157612 1.0164225214353606 1.2078274418170312 1.3623275796691967 1.105933516503887 1.2068270940967774 1.237369790315006 1.1753099520703318 1.0 15.215599078485953 -5.759553405442759 24.42689842720588 1.1999685202425743 1.0144474400930876 0.4378389889096369 0.08871202283193019 30.95549994559624 400913.38676181977 0.023554031142312196 0.038260678965103434 1.7395887666516228e-06 5.759553405442759 -0.18552108014948665 AGMSSNQSIS(ph)SPVLDAVPR ddPTM_A459_Selumetinib_30min_R1 7 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMSSNQS(0.222)IS(0.737)S(0.041)PVLDAVPR;AGMSSNQS(0.022)IS(0.649)S(0.33)PVLDAVPR;AGMS(0.001)S(0.005)NQS(0.009)IS(0.703)S(0.282)PVLDAVPR;AGMSSNQS(0.133)IS(0.813)S(0.054)PVLDAVPR;AGMSSNQS(0.037)IS(0.481)S(0.481)PVLDAVPR;AGMSSNQS(0.007)IS(0.907)S(0.086)PVLDAVPR;AGMSSNQS(0.001)IS(0.5)S(0.5)PVLDAVPR 338.74 1.3276999999999991e-173 571305500.0 15077.22 16316.56 13723.439999999999 14301.399999999998 16569.11 12543.5 16790.190000000002 16141.009999999998 8564.43 13813.589999999998 True False 15428.489890836867 14406.209569837041 11859.872225459985 11803.928960526604 15070.436926013957 12417.323778586751 15523.692450440481 15712.897981410388 14533.212188781776 15586.69883226096 0.9898497466893608 0.9242630350962725 0.7608969899971839 0.7573078230070839 0.9668780469936036 0.7966615581797016 0.9959576827333014 1.0080965925182455 0.9324111760407724 1.0 13.928027785928112 -7.27926725639105 24.163960207788325 0.984791099674716 0.8634962494895251 0.3570173639449975 0.07762595088469279 641.3491193960674 869282.2492780536 0.033997474398866835 0.022985205937910914 5.2569366515832196e-08 7.27926725639105 -0.12129485018519093 AGMSSNQSIS(ph)SPVLDAVPR ddPTM_A459_Selumetinib_30min_R2 2 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMS(0.007)S(0.002)NQS(0.092)IS(0.45)S(0.45)PVLDAVPR;AGMSSNQS(0.3)IS(0.462)S(0.238)PVLDAVPR 134.4 0.00078643 21245400.0 106167.0 90089.0 102505.0 124895.0 120228.0 89920.0 107091.0 111960.0 96295.0 97970.0 True False 100266.66316017439 96998.53661820845 95909.93989900558 107884.08554410769 105123.88378804276 102305.66378751147 112070.94369679074 112285.78506402436 115556.69070710338 95141.3515433705 1.0538704940981156 1.0195202721499215 1.0080783838275065 1.1339347591139524 1.1049231704483584 1.0753017707644723 1.177941472123221 1.180199600305641 1.214579032487535 1.0 16.53778489939542 -6.074181004991878 0.9765854360270988 1.1474968073601965 1.0218455354916927 0.302960137431574 0.0615644178626704 0.6381279883864054 1.2533603579611525 0.026807798088476137 0.05289615965794054 8.429833464488457e-07 6.074181004991878 -0.1256512718685039 AGMSSNQSIS(ph)SPVLDAVPRT(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 AGMSSNQSISSPVLDAVPRTPSR 23 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AGMSSNQSIS(0.889)S(0.111)PVLDAVPRT(0.914)PS(0.086)R 197.98 3.0534e-22 71587000.0 2909.9 2629.6 3913.3 4062.3 3995.7 3119.7 2973.3 2791.6 1626.7 1896.4 True False 2977.695008320248 2321.725209532125 3381.895354218226 3352.8955638152383 3634.2896404981325 3088.3186504609625 2749.021587182438 2717.5576996052428 2760.391090532739 2139.8214125002764 1.3915623943780229 1.0850088684827688 1.5804568243228518 1.566904389417033 1.6984079228610218 1.4432599993718231 1.2846967373647977 1.2699927590825955 1.290010032803325 1.0 11.063274680329902 -8.393990499083758 0.8405460228340413 1.0169349734574655 1.4543466010492894 0.4182990874410969 0.15957228957296626 0.6637059510173844 1.043537344564172 0.16947648201768667 0.062225705985903365 4.036542234804913e-09 8.393990499083758 0.43741162759182384 AGMSSNQSIS(ph)SPVLDAVPRT(ph)PSR ddPTM_A459_Selumetinib_30min_R2 4 AGMSSNQSISSPVLDAVPRTPSR 23 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AGMSSNQSIS(0.697)S(0.303)PVLDAVPRT(0.636)PS(0.364)R;AGMSSNQSIS(0.544)S(0.456)PVLDAVPRT(0.588)PS(0.412)R;AGMS(0.026)S(0.081)NQS(0.103)IS(0.591)S(0.203)PVLDAVPRT(0.765)PS(0.23)R;AGMS(0.121)S(0.144)NQS(0.028)IS(0.385)S(0.322)PVLDAVPRT(0.84)PS(0.16)R 163.75 1.175e-09 62593500.0 124366.0 146545.0 153301.0 143537.0 160821.0 109490.0 75806.3 74024.6 70730.7 154246.0 True False 117454.2355965437 157784.530283557 143437.78056150835 123987.01298486392 140617.22822201852 124571.25364873905 79331.44315733366 74239.99933056775 84878.81638088098 149792.51720076238 0.784112836818967 1.0533538873112276 0.9575764079674489 0.8277250112479776 0.9387466800731675 0.831625344020222 0.5296088525637641 0.49561887815174455 0.5666425664448944 1.0 17.19260603103063 -7.105007798210658 4.260485505363586 0.607547604441394 0.9158195937236518 0.4022317233000997 0.14881629669875304 0.19585133617004163 6.026256552746397 0.05609969431983744 0.043273928886064315 7.852215350113568e-08 7.105007798210658 0.30827198928225785 AGMSSNQSISS(ph)PVLDAVPR ddPTM_A459_Selumetinib_30min_R1 5 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMSSNQS(0.334)IS(0.159)S(0.507)PVLDAVPR;AGMSSNQS(0.012)IS(0.07)S(0.918)PVLDAVPR;AGMSSNQS(0.002)IS(0.023)S(0.975)PVLDAVPR;AGMSSNQS(0.024)IS(0.19)S(0.786)PVLDAVPR;AGMSSNQSIS(0.076)S(0.924)PVLDAVPR 335.14 4.325499999999999e-155 477429000.0 10770.26 14125.8 11882.98 11607.900000000001 12712.869999999999 10824.25 13352.52 12755.4 6786.77 11401.949999999999 True False 11021.186102722175 12471.944769093736 10269.336584536868 9580.79817226963 11562.993153139492 10715.36787263266 12345.32866622447 12417.085356621545 11516.653003931198 12865.50134689808 0.8566464536090095 0.9694099306981744 0.7982072604588273 0.7446890652714125 0.8987596240023226 0.8328760445247767 0.9595684096058157 0.965145859598806 0.8951577317822835 1.0 13.651220057110143 -7.264994250101805 24.641706241940025 0.9520634947237292 0.8505832268310429 0.41926154308308583 0.06042476418854333 286.127866823145 1983370.0157648853 0.025844510463005482 0.018203697239912216 5.43257523973362e-08 7.264994250101805 -0.10148026789268627 AGMSSNQSISS(ph)PVLDAVPR ddPTM_A459_Selumetinib_30min_R2 12 AGMSSNQSISSPVLDAVPR 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMS(0.003)S(0.001)NQS(0.302)IS(0.157)S(0.538)PVLDAVPR;AGMS(0.034)S(0.094)NQS(0.262)IS(0.161)S(0.449)PVLDAVPR;AGMSSNQS(0.064)IS(0.337)S(0.599)PVLDAVPR;AGMS(0.046)S(0.01)NQS(0.301)IS(0.158)S(0.484)PVLDAVPR;AGMS(0.008)S(0.015)NQS(0.127)IS(0.066)S(0.785)PVLDAVPR;AGMSSNQS(0.011)IS(0.188)S(0.801)PVLDAVPR;AGMS(0.001)S(0.009)NQS(0.101)IS(0.307)S(0.583)PVLDAVPR;AGMSSNQS(0.002)IS(0.057)S(0.941)PVLDAVPR;AGMSSNQS(0.001)IS(0.036)S(0.964)PVLDAVPR;AGMSS(0.001)NQS(0.021)IS(0.085)S(0.893)PVLDAVPR;AGMSSNQSIS(0.027)S(0.973)PVLDAVPR;AGMSSNQS(0.005)IS(0.082)S(0.912)PVLDAVPR 287.31 2.8764e-85 1226268700.0 409003.7 385112.4 473198.1 558370.6 585241.3 395062.7 424437.6 532885.5 460462.6 429215.6 True False 386272.9117255364 414649.2827484612 442753.04942513636 482319.5610369886 511718.0557703957 449479.0009028747 444174.7894071489 534436.1085810562 552567.986400008 416823.0303919435 0.9267072199977038 0.9947849627180189 1.0622087004377145 1.1571327058954923 1.2276626252854148 1.0783449284945326 1.065619596377595 1.2821654985774653 1.3256656809016092 1.0 18.669075466339052 -5.374036711386184 1.4835283297599466 1.1715642105656834 0.9273519635448312 0.42682708164373395 0.09468181710814831 0.49797997734056815 1.8955912762334381 0.030196151425626767 0.127942598999885 4.226328871367371e-06 5.374036711386184 -0.2442122470208522 AGMSSNQSISS(ph)PVLDAVPRT(ph)PSR ddPTM_A459_Selumetinib_30min_R1 5 AGMSSNQSISSPVLDAVPRTPSR 23 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AGMSSNQS(0.002)IS(0.449)S(0.548)PVLDAVPRT(0.909)PS(0.091)R;AGMSSNQS(0.002)IS(0.445)S(0.553)PVLDAVPRT(0.902)PS(0.098)R;AGMSSNQSIS(0.43)S(0.57)PVLDAVPRT(0.907)PS(0.093)R;AGMSSNQSIS(0.455)S(0.545)PVLDAVPRT(0.794)PS(0.206)R;AGMS(0.004)S(0.011)NQS(0.011)IS(0.447)S(0.528)PVLDAVPRT(0.831)PS(0.169)R 186.45 1.5059e-21 127817000.0 9753.880000000001 10205.6 13703.099999999999 14962.9 12036.1 9995.1 10528.7 9484.58 6116.409999999999 7961.65 True False 9981.126426253384 9010.723607545277 11842.29428574037 12349.910403419504 10947.436880146046 9894.558368824684 9734.511682295 9233.018128142246 10379.101045088422 8983.60533053829 1.111037947351069 1.0030186407360084 1.3182117702215208 1.3747164917672878 1.218601716944536 1.101401720664393 1.0835863023951116 1.0277631071743678 1.155338047833243 1.0 13.133078833039265 -6.848031439937588 4.264880722647579 1.0721684183398101 1.2096085640907634 0.2926783843349815 0.10291225173701199 0.328708965017077 11.050158096439718 0.04145960444869137 0.036821010090112044 1.4189547953895386e-07 6.848031439937588 0.1374401457509533 AGMSSNQSISS(ph)PVLDAVPRT(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 AGMSSNQSISSPVLDAVPRTPSR 23 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AGMSSNQSIS(0.212)S(0.788)PVLDAVPRT(0.957)PS(0.043)R 150.92 2.3104e-07 38762000.0 16736.0 18139.0 20738.0 20168.0 19010.0 13389.0 8847.1 9727.2 7598.2 20589.0 True False 15805.880119516225 19530.202973922256 19403.739657827176 17421.08360825945 16621.793848443733 15233.21321675922 9258.507680196075 9755.504541575348 9118.052311446232 19994.542073353627 0.790509733182659 0.9767767074770776 0.9704518156325369 0.871291952791268 0.8313165556612224 0.7618685719769624 0.46305174913381614 0.4879083754849448 0.4560270636854294 1.0 14.287318619633874 -6.956189184419866 2.4739404235033073 0.5605185503476852 0.9012743600997348 0.40778038759944246 0.1580672235225361 0.24049253324123915 2.978832191510196 0.06169055195015932 0.05054626995870719 1.106141829002856e-07 6.956189184419866 0.34075580975204967 AGMSSNQSISSPVLDAVPRT(ph)PSR ddPTM_A459_Selumetinib_30min_R1 3 AGMSSNQSISSPVLDAVPRTPSR 23 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMSSNQSISS(0.001)PVLDAVPRT(0.499)PS(0.499)R;AGMSSNQSISSPVLDAVPRT(0.819)PS(0.181)R;AGMSSNQSISSPVLDAVPRT(0.813)PS(0.187)R 102.24 5.0267e-05 39014300.0 3630.35 3683.3599999999997 4689.099999999999 4761.0 4094.4 3926.6 3778.8 3174.4900000000002 2140.25 2632.7799999999997 True False 3714.9300915685826 3252.1104988523903 4052.3459753825887 3929.5807250386115 3724.06224292503 3887.1019690675435 3493.762073670667 3090.29221300324 3631.8479323247648 2970.7229584488887 1.2505138121355714 1.0947202227670612 1.3640942060441916 1.3227691642745354 1.2535878622857126 1.3084700335359196 1.1760645884983076 1.0402492107903532 1.2225468288773285 1.0 11.536598354289078 -7.506036939375369 4.926676015524193 1.0988435227178015 1.2635753241532697 0.4659623517822402 0.08546195813669749 0.18059507658756352 12.236769383670493 0.03944596239031452 0.024259016143147124 3.1186243149312487e-08 7.506036939375369 0.16473180143546817 AGMSSNQSISSPVLDAVPRT(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 AGMSSNQSISSPVLDAVPRTPSR 23 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AGMSSNQSISSPVLDAVPRT(0.5)PS(0.5)R 95.141 0.0073976 0.0 11315.0 11271.0 13805.0 14276.0 13246.0 10643.0 8338.1 9056.6 7004.2 14120.0 True False 10686.157597533816 12135.449458022918 12916.80132974753 12331.584172526382 11581.91905925753 12108.976642465333 8725.838171631705 9082.953206599157 8405.235713699514 13712.318911834134 0.7793107545297352 0.885003443695411 0.9419851895801483 0.8993069846037393 0.8446360629245572 0.8830728573571119 0.636350294048445 0.6623936669646956 0.6129696784141703 1.0 13.743184947727675 -7.2495089905879535 24.122676644119274 0.6997945502856252 0.8759489944216912 0.2828612606566142 0.1088321802439514 477.4484695008358 965379.4719542606 0.039626658086459 0.030427699272723274 5.629774627428571e-08 7.2495089905879535 0.17615444413606596 AGMTHIVR ddPTM_A459_Selumetinib_30min_R1 2 AGMTHIVR 8 0 H7C422;H7C3M2;F8WCR1;P39023 H7C422;P39023 RPL3 60S ribosomal protein L3 0 ; 148.04 0.0022808000000000004 21334800.0 17003.2 17664.9 19821.8 19239.1 18606.0 16379.4 16995.4 16747.8 9695.5 14198.3 False True 17399.34147753216 15596.68529581079 17130.108433353664 15879.352347635015 16923.090585156093 16214.63810730529 15713.423294924956 16303.593939478678 16452.555368697456 16020.790108153697 1.0860476518369002 0.9735278466617535 1.0692424229835822 0.9911716114146769 1.0563205978551067 1.0120997777165146 0.9808145034574601 1.0176523023780861 1.0269503100426998 1.0 13.967657679418819 -6.978784586387185 24.439686606700988 1.0062012749629965 1.0315646417242852 0.1435162601320702 0.03353405716356668 389.6279088623773 448840.0981913233 0.010985113612012914 0.009687216991575844 1.0500631394032928e-07 6.978784586387185 0.025363366761288697 AGMTHIVR ddPTM_A459_Selumetinib_30min_R2 2 AGMTHIVR 8 0 H7C422;H7C3M2;F8WCR1;P39023 H7C422;P39023 RPL3 60S ribosomal protein L3 0 ; 131.03 0.005158 12484600.0 127067.0 123997.0 133703.0 140913.0 147233.0 116455.0 118779.0 121922.0 106588.0 123558.0 False True 120005.12482950326 133507.17118680404 125100.69454481971 121720.40631151665 128736.27426027956 132495.61917676416 124302.45885612337 122276.77283472626 127908.57831755304 119990.55949776225 1.0001213873141517 1.1126472928005129 1.0425878091447083 1.0144165242748673 1.0728866904123437 1.1042170295008509 1.0359353217153848 1.019053276745548 1.065988681550722 1.0 16.87256137775786 -9.647093626134172 0.562544048685086 0.9953998314284936 1.0556837235118037 0.1545946260912764 0.03561618652026117 10.039633285162706 3.4406530946027187 0.14226960592045587 0.015630627506600672 2.2537532908169278e-10 9.647093626134172 0.06028389208331009 AGNALT(ph)PELAPVQIK ddPTM_A459_Selumetinib_30min_R1 2 AGNALTPELAPVQIK 15 0 P0C1Z6-2;P0C1Z6 P0C1Z6-2 TFPT TCF3 fusion partner 1 AGNALT(1)PELAPVQIK;AGNALT(1)PELAPVQIK 152.94 0.00050796 21704200.0 4663.299999999999 5654.700000000001 5297.2 5190.0 5005.6 4696.6 5680.299999999999 5310.4 3038.0 4673.3 True False 4771.945816797763 4992.645095201294 4577.8693354367915 4283.663928365972 4552.844363810457 4649.356468171608 5251.830397764232 5169.550941389768 5155.264113259031 5273.163576796843 0.9049493244995176 0.9468026209484766 0.868144761444627 0.8123518009596932 0.8633990388320288 0.8817015441413324 0.9959543870160823 0.9803509536736174 0.9776416070124209 1.0 12.364453035366799 -7.2570736748199005 23.012909919453914 0.9868493248104033 0.8783065997617419 0.7310070923395513 0.03235962467184207 74.29721291301308 391644.94324784866 0.01449928820294462 0.010809386773709814 5.53256245458444e-08 7.2570736748199005 -0.10854272504866147 AGNALT(ph)PELAPVQIK ddPTM_A459_Selumetinib_30min_R2 2 AGNALTPELAPVQIK 15 0 P0C1Z6-2;P0C1Z6 P0C1Z6-2 TFPT TCF3 fusion partner 1 AGNALT(1)PELAPVQIK;AGNALT(1)PELAPVQIK 122.16 0.0037213 13799500.0 86111.0 73966.0 79853.0 95443.0 86892.0 75315.0 72344.0 78550.0 75741.0 81908.0 True False 81325.29534964524 79638.95436182432 74715.34491737263 82443.49875164137 75975.85013566395 85688.95760850105 75708.1393469165 78778.56749534747 90891.3163803598 79543.10321745819 1.0224053633828545 1.001205021434782 0.9393063872943548 1.0364631931225257 0.9551532070349086 1.0772644533900202 0.9517876004905478 0.9903884096648756 1.1426674683772067 1.0 16.279449226695164 -8.214777023789416 24.985835139429806 1.0713339090116467 0.9961033409257561 0.25489361679303046 0.05100022279633752 446.42254562075505 239041.95183069963 0.03182673165164305 0.012029273860562562 6.098499270605734e-09 8.214777023789416 -0.07523056808589057 AGNS(ph)DSEEDDANGR ddPTM_A459_Selumetinib_30min_R2 1 AGNSDSEEDDANGR 14 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 AGNS(0.995)DS(0.005)EEDDANGR 184.21 1.1365999999999999e-14 0.0 2847.7 1109.3 2711.7 2557.0 2934.7 960.93 2301.4 4259.0 3077.2 2712.7 True False 2689.436234246314 1194.3797430383127 2537.232174275723 2208.7321889289683 2566.0167494491234 1093.2893850459668 2408.4196601375875 4271.392984884593 3692.7259841518194 2634.377302558955 1.0209001693242181 0.45338218708388056 0.9631240641995861 0.8384266698560879 0.974050583778023 0.415008656498816 0.9142273044176782 1.6214051725755039 1.4017452931153092 1.0 11.363246271694813 -7.622904698915344 6.016447171169129 1.3778176558775068 0.7738274223282952 0.5223845859195688 0.24026576113161613 0.14814258086486118 7.542903905065698 0.11050774393970463 0.06281149594249778 2.3828423001823565e-08 7.622904698915344 -0.6039902335492117 AGNSDS(ph)EEDDANGR ddPTM_A459_Selumetinib_30min_R2 1 AGNSDSEEDDANGR 14 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 AGNS(0.118)DS(0.882)EEDDANGR 159.64 0.00029672 1480400.0 2276.9 2527.5 2695.9 3665.9 2308.1 2910.7 2492.9 3493.8 3266.6 2691.8 True False 2150.3590131528736 2721.3511228065763 2522.448729073985 3166.598095969771 2018.1358433241978 3311.622504296144 2608.8247895876384 3503.966379570275 3920.011276429977 2614.0807398636784 0.8226061958839926 1.0410356043358064 0.9649467557017875 1.2113620087093813 0.7720250612570756 1.2668401758963428 0.9979893695722979 1.3404201049096147 1.4995754402881991 1.0 11.352087986316487 -7.43948067753331 1.4875603093515757 1.3010096343766866 0.9937845779171856 0.2774160869778406 0.18694216994185553 0.49550014568318457 2.1140471463735615 0.11695958394962258 0.059617520243016475 3.635124774466781e-08 7.43948067753331 -0.30722505645950104 AGNWPGS(ph)PQVSGPSPAAR ddPTM_A459_Selumetinib_30min_R2 1 AGNWPGSPQVSGPSPAAR 18 0 H7C3E5;O60244 H7C3E5 MED14 Mediator of RNA polymerase II transcription subunit 14 1 AGNWPGS(0.88)PQVS(0.114)GPS(0.005)PAAR 108.25 0.0015321 6647200.0 20719.0 18418.0 20088.0 21703.0 25798.0 17684.0 21106.0 22516.0 18682.0 20639.0 True False 19567.520924728517 19830.60137679586 18795.55995016068 18747.013960236767 22557.02460295379 20119.81048063112 22087.47082074558 22581.517832275542 22418.92201869371 20043.098443438008 0.9762722555072221 0.9893979931674827 0.9377572037178831 0.9353351236158015 1.1254260246543282 1.0038273542092104 1.1019988193480579 1.1266480527449885 1.1185357434610381 1.0 14.290817930170881 -6.256475096244955 24.988635522724714 1.0830891113138534 0.9602459193503277 0.6234683023519418 0.04552257084979265 277.1982092573241 1395326.9451301987 0.013699136853430974 0.01715466260737026 5.5401931216554e-07 6.256475096244955 -0.12284319196352578 AGNWPGSPQVS(ph)GPSPAAR ddPTM_A459_Selumetinib_30min_R2 1 AGNWPGSPQVSGPSPAAR 18 0 H7C3E5;O60244 H7C3E5 MED14 Mediator of RNA polymerase II transcription subunit 14 1 AGNWPGS(0.019)PQVS(0.98)GPS(0.001)PAAR 210.57 1.1189e-11 4650000.0 28873.0 24295.0 27906.0 32608.0 31985.0 21711.0 21941.0 26959.0 20654.0 22260.0 True False 27268.354247776773 26158.34837926242 26110.5583417555 28166.73414806249 27966.758350472006 24701.493177164808 22961.29997526669 27037.446226697284 24785.377120977402 21617.29596157422 1.2614137446352025 1.2100657004354356 1.2078549689178641 1.3029721292677037 1.2937213979113882 1.142672664567895 1.0621726239989269 1.2507321116738024 1.1465530732906928 1.0 14.399898451798455 -6.816918701376961 7.886527085821004 1.1318536561140138 1.2526153916123153 0.49974940934452505 0.06693097206180158 0.2426040461228694 30.03339912697243 0.02373451957028009 0.021007680207593436 1.5243380786019588e-07 6.816918701376961 0.12076173549830149 AGPDLPSLPSHALEDEGWAAAAPS(ph)PGSAR ddPTM_A459_Selumetinib_30min_R1 6 AGPDLPSLPSHALEDEGWAAAAPSPGSAR 29 0 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 AGPDLPSLPSHALEDEGWAAAAPS(0.979)PGS(0.021)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.822)PGS(0.178)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.806)PGS(0.194)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.76)PGS(0.24)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.981)PGS(0.019)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.602)PGS(0.398)AR 297.91 4.170699999999997e-126 506292000.0 16729.12 20335.489999999998 19761.500000000004 21858.09 23884.47 17090.23 21318.840000000004 18215.32 8756.809999999998 14892.939999999999 True False 17118.875946799 17954.601377087183 17077.996842149463 18040.984908666072 21724.123905645672 16918.317802887294 19710.742734903455 17732.190541901917 14859.6669979025 16804.593918520277 1.018702149531406 1.0684341117757976 1.0162695346852666 1.0735745830063275 1.2927491143778012 1.0067674282948118 1.1729377591909746 1.0551989906973795 0.8842621886581692 1.0 14.036568060022471 -8.094971416390866 5.632901536864391 0.9455107518681234 1.093959957605162 0.32528062963745186 0.08541453922646126 0.26768592011072223 12.524227647666164 0.05946917017716497 0.02189466403606527 8.035790089557737e-09 8.094971416390866 0.14844920573703857 AGPDLPSLPSHALEDEGWAAAAPS(ph)PGSAR ddPTM_A459_Selumetinib_30min_R2 4 AGPDLPSLPSHALEDEGWAAAAPSPGSAR 29 0 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 AGPDLPSLPSHALEDEGWAAAAPS(0.747)PGS(0.253)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.98)PGS(0.02)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.824)PGS(0.176)AR;AGPDLPSLPSHALEDEGWAAAAPS(0.925)PGS(0.075)AR 169.14 1.6837e-23 261545200.0 173840.0 167029.0 205218.0 227213.0 242013.0 186054.0 158785.0 180456.0 160432.0 207215.0 True False 164178.66873665736 179839.5872171156 192014.4973044641 196266.19743571256 211609.1633163291 211681.24966994682 166168.81712650837 180981.09708390082 192522.88284461322 201232.16454077244 0.8158669321642787 0.8936920577658329 0.9541938672808904 0.9753222000250675 1.051567296904239 1.0519255217127939 0.8257567447317312 0.8993646592080041 0.9567202305057222 1.0 17.618501395458665 -4.930893498488272 2.007200950120606 0.963056664499964 0.7972024425756924 0.3558749986690348 0.06344898763258765 0.6806431936925735 3.852029714614324 0.019263626602060477 0.18821973005212933 1.172482856852251e-05 4.930893498488272 -0.16585422192427157 AGPGS(ph)SPLFSLLPGYR ddPTM_A459_Selumetinib_30min_R1 1 AGPGSSPLFSLLPGYR 16 0 Q9H0W8-2;Q9H0W8 Q9H0W8-2 SMG9 Protein SMG9 1 AGPGS(0.637)S(0.363)PLFSLLPGYR 227.74 4.0975e-15 29991000.0 1277.1 1492.7 1757.2 1685.1 1442.2 1203.7 1130.1 1239.0 723.02 876.36 True False 1306.8539451959819 1317.9339900625969 1518.5818916086864 1390.8289182446042 1311.753264641091 1191.591870872155 1044.8556471512702 1206.1376951608029 1226.9121327085393 988.849342469279 1.321590548801505 1.3327955366502573 1.5357060235451032 1.406512456964913 1.3265451149165766 1.2050287335951528 1.0566378539951662 1.219738582369816 1.2407472807179991 1.0 9.949606923671999 -6.715034950967967 2.501810554443969 1.1458231380139112 1.4019189439331403 0.6715272316244529 0.08592390400490525 0.18281065991179715 2.3419753365840394 0.03304863712103674 0.0314649202768642 1.9273697968964988e-07 6.715034950967967 0.2560958059192291 AGPGSS(ph)PLFSLLPGYR ddPTM_A459_Selumetinib_30min_R1 1 AGPGSSPLFSLLPGYR 16 0 Q9H0W8-2;Q9H0W8 Q9H0W8-2 SMG9 Protein SMG9 1 AGPGS(0.026)S(0.974)PLFSLLPGYR 209.22 5.6273e-08 27219000.0 1058.7 1171.9 1085.3 1223.8 1183.8 1002.0 966.05 1102.5 605.62 865.31 True False 1083.3656501284052 1034.6934031984704 937.9222211261706 1010.0863035711515 1076.7254990168656 991.9207897432077 893.1800707286825 1073.2581185752904 1027.6929072652845 976.380967333164 1.1095726835883062 1.059723036208477 0.960610921869936 1.0345206813381957 1.1027719046570288 1.0159157367154426 0.9147864415754313 1.0992206469435097 1.0525531955751568 1.0 9.931300362606121 AGPSAQEPGS(ph)QTPLK ddPTM_A459_Selumetinib_30min_R1 2 AGPSAQEPGSQTPLK 15 0 A0A087X2D8;O60271-4;O60271-2;O60271-9;O60271 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 AGPS(0.001)AQEPGS(0.532)QT(0.468)PLK;AGPSAQEPGS(0.5)QT(0.5)PLK 188.39 2.4909e-05 8665000.0 2315.6 3221.2 2842.2 2874.3 2850.2 2531.1 2671.8 2805.0 1444.4 1859.85 True False 2369.5489746267444 2844.0604065047482 2456.2448510870754 2372.357462293316 2592.3999132436816 2505.6394320549234 2470.2639749214786 2730.6022880759083 2451.041305197941 2098.5798639731274 1.1291202280672825 1.3552309613417537 1.1704319160085717 1.130458508165546 1.23531153507574 1.193969062159556 1.177112206844805 1.301166724675518 1.167952360201111 1.0 11.03519765242036 -8.548482095509394 22.39176048639271 0.9999999977466897 1.2128136487739023 0.46710609072019693 0.06768160189886964 1558.017368534136 1362584.5841303365 0.06317240022201237 0.016311043581685544 2.8282507078418826e-09 8.548482095509394 0.2128136510272126 AGPSAQEPGSQT(ph)PLK ddPTM_A459_Selumetinib_30min_R1 2 AGPSAQEPGSQTPLK 15 0 A0A087X2D8;O60271-4;O60271-2;O60271-9;O60271 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 AGPSAQEPGS(0.029)QT(0.971)PLK;AGPSAQEPGS(0.426)QT(0.574)PLK 221.34 4.0938e-09 16083500.0 6468.799999999999 6488.700000000001 6511.7 6766.9 6760.4 5128.1 6399.5 6084.5 3553.4 5273.5 True False 6619.510453906328 5728.999987485208 5627.446906207762 5585.187945445031 6148.923013645561 5076.515969942261 5916.7805627329935 5923.119294758597 6029.860269932403 5950.405093239931 1.1124470267455482 0.9627915911126362 0.9457250083025319 0.9386231454712534 1.0333620849832827 0.8531378772362124 0.9943492031248196 0.995414463712339 1.0133529021045538 1.0 12.538772172597717 -7.501408574177809 24.954511931280372 1.001606614556953 0.969427052966674 0.0382143477325293 0.063086583214415 2563.628557627882 2979685.0910072946 0.02657400169150974 0.017694779554996584 3.152037863933768e-08 7.501408574177809 -0.03217956159027913 AGPSAQEPGSQT(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 AGPSAQEPGSQTPLK 15 0 A0A087X2D8;O60271-4;O60271-2;O60271-9;O60271 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 AGPSAQEPGS(0.386)QT(0.613)PLK;AGPSAQEPGS(0.034)QT(0.966)PLK 192.23 6.9377e-05 38957000.0 86746.0 88375.0 91353.0 93842.0 90159.0 76911.0 84079.0 81909.0 56595.0 88772.0 True False 81925.00459175148 95153.0783295872 85475.4474376259 81060.55771352063 78832.42038831342 87504.79212145561 87988.84009937792 82147.34162923503 67915.58139642289 86208.92170264469 0.9503077288720828 1.1037497796085776 0.9914918983959837 0.9402803806445694 0.9144345948349221 1.0150317437362306 1.0206465683780688 0.9528867779205148 0.787802237344762 1.0 16.39554956011809 -5.872692634535312 0.4992149273033534 0.9331481761840092 1.0408862098522071 0.11951728356984692 0.07366819211106847 3.761652729339935 1.5141103810847463 0.05924224075638359 0.2134630795927534 1.340625159283809e-06 5.872692634535312 0.1077380336681979 AGQAVDDFIEK ddPTM_A459_Selumetinib_30min_R1 1 AGQAVDDFIEK 11 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 154.15 0.007591 5947000.0 5716.0 6137.5 7412.7 7727.0 6047.4 6207.2 6388.8 6099.3 4041.3 6195.1 False True 5849.171678600136 5418.918646753659 6406.096055046496 6377.624503754117 5500.413737755185 6144.761203686667 5906.88767234761 5937.526750681422 6857.790935126305 6990.3014303841255 0.8367552868573104 0.7752052898891777 0.9164262970408807 0.9123532893779172 0.7868635984489915 0.879040949075211 0.8450118683970712 0.849394952394084 0.981043665058298 1.0 12.77113895238642 -8.28879620557997 4.67666173107673 0.9965180183329448 0.8502446370956163 0.6246402131981399 0.04359822675524879 0.1330140021122069 7.359080455120053 0.04011986148812025 0.011325361245705125 5.14284925223696e-09 8.28879620557997 -0.14627338123732858 AGQAVDDFIEK ddPTM_A459_Selumetinib_30min_R2 2 AGQAVDDFIEK 11 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 ; 167.6 0.007310600000000001 17146600.0 86402.0 79314.0 83661.0 88692.0 90882.0 68011.0 68009.0 77850.0 64749.0 75042.0 False True 81600.12273461052 85397.12876529396 78278.34234320943 76611.99659776615 79464.59066461146 77378.89790761168 71171.55325727694 78076.53061123868 77700.60923821837 72875.34247746854 1.1197219794862643 1.1718247333341436 1.0741403015349311 1.051274601165036 1.0904180750736117 1.0617980688260305 0.9766204979315415 1.0713710283471838 1.0662126117931 1.0 16.153143137819832 -5.420916279797542 4.055979872710577 1.0487176724075806 1.1451025885942714 0.5690006196226862 0.03430254561162836 0.16551465266738874 4.713617103176742 0.00933232952280003 0.020517373470727372 3.7938811366800586e-06 5.420916279797542 0.09638491618669076 AGQDMGLEHGFEKPLDSAMS(ph)AEEDTDVR ddPTM_A459_Selumetinib_30min_R1 2 AGQDMGLEHGFEKPLDSAMSAEEDTDVR 28 1 Q99549-2;Q99549;A0A0A0MT47 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 AGQDMGLEHGFEKPLDS(0.189)AMS(0.77)AEEDT(0.04)DVR;AGQDMGLEHGFEKPLDS(0.26)AMS(0.689)AEEDT(0.051)DVR 68.271 0.00029241 27763000.0 4621.6 5576.6 5541.6 6394.9 5640.8 5022.2 4938.3 4679.3 3050.4 4148.299999999999 True False 4729.274287931841 4923.689079508994 4789.081157829893 5278.150762140182 5130.590635964128 4971.681227792753 4565.800055151859 4555.189763491478 5176.3060075988615 4680.7747128637875 1.0103614418644773 1.051896188461629 1.023138572482127 1.12762332859872 1.0960986056141835 1.062149223744841 0.9754368315578288 0.9731700504561402 1.1058652306792818 1.0 12.19253161402391 -7.175785012698165 9.505601200744008 1.0114256327305091 1.064312432189566 0.20409994500423445 0.04646492106117432 0.69586859289194 73.19679904995681 0.01834003164633931 0.014202114440018834 6.671369379867759e-08 7.175785012698165 0.05288679945905694 AGQEPS(ph)PKPGTDVIPAAPR ddPTM_A459_Selumetinib_30min_R1 3 AGQEPSPKPGTDVIPAAPR 19 1 Q4VC44-2;Q4VC44;Q4VC44-3;I3L0R3;I3L231 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 AGQEPS(0.971)PKPGT(0.029)DVIPAAPR;AGQEPS(0.964)PKPGT(0.036)DVIPAAPR;AGQEPS(0.963)PKPGT(0.037)DVIPAAPR 75.73 0.005013 22337200.0 2924.87 2767.2 4082.5699999999997 3759.3 3094.89 3016.8 3089.25 2950.28 2042.94 3050.45 True False 2993.013780193699 2443.2149375636213 3528.1794179517824 3102.808825800811 2814.9577459472102 2986.4537310352407 2856.2253853305547 2872.0289905399595 3466.7199695659624 3442.0049713992103 0.8695553333198727 0.7098231867371271 1.0250361191423676 0.9014539059597835 0.8178250087776314 0.8676494531096557 0.8298144276559455 0.8344058228865516 1.0071804074578967 1.0 11.749033465772861 -8.266116796970849 24.61328058878867 1.0035902388047344 0.8572763943789672 0.3850259949879833 0.07413178462203754 354.5711337850858 1865762.8594344745 0.06432369897819525 0.018741101834333883 5.4185514701031025e-09 8.266116796970849 -0.14631384442576723 AGQEPS(ph)PKPGTDVIPAAPR ddPTM_A459_Selumetinib_30min_R2 2 AGQEPSPKPGTDVIPAAPR 19 1 Q4VC44-2;Q4VC44;Q4VC44-3;I3L0R3;I3L231 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 AGQEPS(0.998)PKPGT(0.002)DVIPAAPR;AGQEPS(0.959)PKPGT(0.041)DVIPAAPR 78.166 0.004218199999999999 34149000.0 56232.0 61537.0 59557.0 71262.0 63720.0 52632.0 53729.0 66809.0 44500.0 52050.0 True False 53106.85055453131 66256.69002735846 55725.167460758705 61555.99266619318 55714.923935972394 59881.58025427375 56227.504961993756 67003.40312917459 53401.24343388664 50547.18125785884 1.0506392094074386 1.310789016886222 1.102438673612385 1.2177927855595854 1.1022360208722835 1.1846670529222367 1.112376665973867 1.3255616131662575 1.0564633300018893 1.0 15.625343022643275 -8.509440607711037 24.237704967844017 0.9999999674161103 1.1759946418875893 0.3330588014147571 0.08542490498162593 415.5832853554125 749566.431531092 0.07479859437657159 0.019312914006992254 3.0942784470401336e-09 8.509440607711037 0.17599467447147898 AGQHS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 2 AGQHSPLR 8 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 AGQHS(1)PLR;AGQHS(1)PLR 80.916 0.029761000000000006 5425400.0 10991.1 7322.4 7481.4 9996.5 10010.3 15065.9 44595.0 128634.0 31339.0 25760.0 True False 10380.258662859385 7884.004534773051 7000.0548691324275 8634.959455075645 8752.716620782552 17141.090970376634 46668.75586331611 129008.30364349477 37607.67568482183 25016.24186748211 0.4149407699944085 0.315155432879838 0.27982040252943013 0.3451741273056677 0.34988135576670915 0.6851984826968691 1.8655382415365707 5.156981785149309 1.5033303516987082 1.0 14.610577452571112 -7.358541440412633 3.515410589611706 2.8498988076838088 0.3726244090531366 0.4609367418687519 1.0434144011506918 0.18328561826147283 4.2438520118836225 0.4443336560293671 0.2875579322104973 4.3798431667942595e-08 7.358541440412633 -2.477274398630672 AGQS(ph)AAGAAPGGGVDTR ddPTM_A459_Selumetinib_30min_R2 1 AGQSAAGAAPGGGVDTR 17 0 P21333-2;P21333 P21333-2 FLNA Filamin-A 1 AGQS(1)AAGAAPGGGVDTR 91.926 0.015724000000000002 0.0 4673.8 5737.0 6282.4 5505.2 7546.5 4665.6 5256.5 7446.2 4001.4 6155.3 True False 4414.048906703809 6177.009452637522 5878.197223759929 4755.382263000294 6598.441203434018 5308.244049900055 5500.93766555715 7467.8672092152265 4801.791808457392 5977.580495609965 0.7384340386458301 1.0333628224954932 0.9833739969000795 0.7955362987571186 1.1038648845097148 0.888025523671077 0.9202615790112957 1.2493126967842179 0.8033002335951659 1.0 12.545345937425905 -4.753090578272334 24.919026416504728 0.9772340348450996 0.7384335757845374 0.23061228912150478 0.1297072365139575 444.41542255401623 1326359.211744131 0.030654786327591728 0.34066068291035456 1.7656695268646887e-05 4.753090578272334 -0.23880045906056224 AGQTQPNPGILPIQPALT(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 AGQTQPNPGILPIQPALTPR 20 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 AGQTQPNPGILPIQPALT(1)PR;AGQTQPNPGILPIQPALT(1)PR;AGQTQPNPGILPIQPALT(1)PR;AGQTQPNPGILPIQPALT(1)PR 150.13 3.4315e-05 49313100.0 94624.0 84649.0 94562.0 105168.0 119521.0 91685.0 93261.0 87878.0 80982.0 92649.0 True False 89365.17688988417 91141.30611056548 88477.98387132102 90843.93697508067 104505.70344870295 104313.77651643654 97597.82129316563 88133.71043101403 97180.66282613503 89973.98263898876 0.993233535614986 1.0129740113457073 0.9833729849030882 1.0096689544085484 1.1615102542256155 1.1593771161046045 1.0847338133821054 0.9795466183223362 1.0800973789952404 1.0 16.457220263834948 -6.032315781456941 24.284798359279055 1.0813923955948979 0.9978964469267612 0.32660952081326344 0.054745430032315884 564.2196132456536 424001.31849842035 0.01752079967894998 0.022643020522960404 9.282911681262332e-07 6.032315781456941 -0.0834959486681367 AGS(ph)EECVFYTDETASPLAPDLAK ddPTM_A459_Selumetinib_30min_R1 2 AGSEECVFYTDETASPLAPDLAK 23 0 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 AGS(1)EECVFYTDETASPLAPDLAK;AGS(1)EECVFYTDETASPLAPDLAK 218.85 1.0408e-26 25775000.0 14998.3 15721.7 18369.0 19382.4 14368.7 15761.5 14142.7 13979.7 8522.2 11946.5 True False 15347.731208388466 13880.996055179965 15874.590693694478 15997.627692709175 13069.053622000021 15602.95362029698 13075.904752646902 13608.912943534679 14461.550963138929 13479.949643764261 1.1385599808592928 1.0297513286039035 1.1776446584159135 1.1867720663266406 0.9695179854062498 1.1574934649340332 0.9700262314181368 1.0095670461076296 1.0728193610002654 1.0 13.718527486690343 -6.730259871731247 1.2354040462755853 1.021302369116708 1.1210988279105116 0.2731478335559139 0.0702184159223858 0.6385398412624781 2.0548112596894366 0.034300546954765164 0.0318420234320958 1.860973240266369e-07 6.730259871731247 0.09979645879380361 AGS(ph)ISPGSPPYPQSR ddPTM_A459_Selumetinib_30min_R2 1 AGSISPGSPPYPQSR 15 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5 Q63HR2-6 TNS2 Tensin-2 1 AGS(0.958)IS(0.042)PGSPPYPQSR 160.46 5.7409e-05 0.0 13320.0 11003.0 15236.0 15607.0 17668.0 13949.0 10379.0 14532.0 10198.0 13776.0 True False 12579.727724184757 11846.894719778738 14255.732347702515 13481.299676423312 15448.387886075958 15870.348133585368 10861.644065598339 14574.285714097896 12237.884955927539 13378.251085653472 0.9403118272817415 0.8855338895891314 1.0655901325540251 1.007702695226011 1.154738970525262 1.1862797335747692 0.8118881904710337 1.0894014188242456 0.914759700470203 1.0 13.707601906965976 -5.260114018828371 24.935098518893707 1.0336104840600018 0.9129228530751713 0.1638213606607134 0.10426064178255177 189.8021799770706 3570814.180825075 0.02713465839051934 0.06404682882291635 5.4939661740295205e-06 5.260114018828371 -0.12068763098483049 AGS(ph)ISSEEVDGSQGNMMR ddPTM_A459_Selumetinib_30min_R2 2 AGSISSEEVDGSQGNMMR 18 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 AGS(0.946)IS(0.047)S(0.007)EEVDGSQGNMMR;AGS(0.333)IS(0.333)S(0.333)EEVDGSQGNMMR 252.25 4.0147e-33 7468500.0 21174.2 18695.5 20433.6 21487.0 27399.0 16235.4 16420.0 15573.8 15127.3 16337.400000000001 True False 19997.422731038507 20129.38473449273 19118.92442242151 18560.433532857533 23956.892669832203 18471.67897971265 17183.562535612742 15619.117179618625 18153.182692077145 15865.696812337044 1.2604188122067645 1.2687362536034519 1.2050478871848087 1.1698467298596733 1.5099804914463957 1.1642526135599172 1.0830638413719678 0.9844583168558546 1.144178091060039 1.0 13.953623264538182 -7.089664220113806 3.9979076469715125 1.0537433989722171 1.2762153717776439 0.5603360709072794 0.09505617265006135 0.1842501150198142 5.340941699531487 0.03772605942747824 0.02921343504286811 8.134592086461209e-08 7.089664220113806 0.22247197280542674 AGS(ph)ISTLDSLDFAR ddPTM_A459_Selumetinib_30min_R1 3 AGSISTLDSLDFAR 14 0 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 AGS(0.991)IS(0.007)T(0.002)LDSLDFAR;AGS(0.485)IS(0.485)T(0.03)LDSLDFAR;AGS(0.523)IS(0.238)T(0.238)LDSLDFAR 273.08 1.3798e-44 45414800.0 4255.6 5359.5 5901.8 5273.9 4531.3 4431.5 4541.0 4492.5 2562.7 3469.3900000000003 True False 4354.747200043868 4732.00724843605 5100.367976266872 4352.9123683640255 4121.444715065993 4386.923133480066 4198.468714019928 4373.344306303391 4348.714727797536 3914.7200012203807 1.1124032366775434 1.2087728488783072 1.3028691642510513 1.111934536060572 1.0528070242012628 1.1206224537418972 1.072482505188389 1.1171537951475554 1.1108622651024496 1.0 11.934693407683703 -5.956456334357365 13.149760431823545 1.0862168189072874 1.2080314726945067 0.5274926368162451 0.054429744635656176 1.0051985344964802 302.0073869778801 0.015105935039947498 0.02240530979758659 1.1054616111704823e-06 5.956456334357365 0.12181465378721934 AGS(ph)ISTLDSLDFAR ddPTM_A459_Selumetinib_30min_R2 4 AGSISTLDSLDFAR 14 0 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 AGS(0.982)IS(0.004)T(0.014)LDS(0.001)LDFAR;AGS(0.832)IS(0.117)T(0.046)LDS(0.004)LDFAR;AGS(0.333)IS(0.333)T(0.333)LDS(0.001)LDFAR;AGS(0.976)IS(0.007)T(0.017)LDSLDFAR 214.48 1.16e-06 19610700.0 36942.5 37200.8 43398.9 46998.1 54807.2 31999.4 37930.4 42502.2 34611.3 43525.0 True False 34889.383742544676 40053.98174057486 40606.6620231496 40596.877703755395 47921.829553415315 36407.02688836845 39694.23875766173 42625.87436538201 41534.52712052316 42268.3201584689 0.8254263148320131 0.947612339227293 0.9606878596289242 0.9604563784780878 1.1337528762380606 0.8613312937886868 0.939101402867286 1.008459153464642 0.9826396451244179 1.0 15.367289156994959 -4.389493928696694 1.4474783851584152 0.9813874789049765 0.5804503002289838 0.34590441842522834 0.0642186806667645 3.855673438112766 3.4951244009901625 0.01840962881596075 2.948256524522769 4.0785526342257854e-05 4.389493928696694 -0.40093717867599266 AGS(ph)PDVLR ddPTM_A459_Selumetinib_30min_R2 1 AGSPDVLR 8 0 Q8NDX6 Q8NDX6 ZNF740 Zinc finger protein 740 1 AGS(1)PDVLR 91.265 0.027107 11546000.0 70737.0 61760.0 69262.0 69696.0 54886.0 46787.0 66128.0 56582.0 46891.0 48873.0 True False 66805.7207226469 66496.79341030041 64805.75832676378 60203.28456769398 47990.72999293443 53231.484559900964 69203.08303014614 56746.64425234565 56270.510244008496 47461.90950269617 1.407564959409226 1.4010560069548597 1.3654266970249556 1.2684547503145445 1.0111419977784126 1.1215622194230732 1.4580762500972473 1.1956249726767112 1.1855930541693003 1.0 15.534482524216434 -1.5228787452803376 0.23773664436218558 1.1219232681713 3.007499039241662 0.3801806211332134 0.12373862252316405 63.854170672444376 0.8493800058328105 0.18808641540751164 47.35593406596374 0.029999999999999995 1.5228787452803376 1.885575771070362 AGS(ph)PFSPPPSSSSLTGEAAISR ddPTM_A459_Selumetinib_30min_R1 3 AGSPFSPPPSSSSLTGEAAISR 22 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;C9J0X3;C9K0F0;C9J760;Q96JY6-2;A0A087WXJ0 Q96JY6;A0A087WXJ0 PDLIM2 PDZ and LIM domain protein 2 1 AGS(1)PFSPPPSSSSLTGEAAISR;AGS(1)PFSPPPSSSSLTGEAAISR;AGS(1)PFSPPPSSSSLTGEAAISR 196.01 3.479100000000001e-22 39052200.0 7571.22 9026.32 9017.3 9627.48 7906.629999999999 7748.360000000001 7485.3099999999995 6733.66 4110.13 6376.800000000001 True False 7747.614694970419 7969.514258177679 7792.800188483383 7946.221348182044 7191.476712528902 7670.418533347985 6920.687040242346 6555.061462789742 6974.590417982003 7195.324395292007 1.0767568311499316 1.107596241719447 1.0830366722009521 1.1043590131087568 0.9994652523567079 1.066028174958566 0.9618311364489196 0.911016807953621 0.9693225815566519 1.0 12.81284401581517 -6.894990269601313 1.115465895819397 0.9511498206077326 1.0923848778609453 0.7146130397620323 0.03467194448080595 0.24641152770238306 0.6419749882506134 0.019495585383807933 0.015460274776613317 1.273531614263211e-07 6.894990269601313 0.14123505725321273 AGS(ph)PFSPPPSSSSLTGEAAISR ddPTM_A459_Selumetinib_30min_R2 1 AGSPFSPPPSSSSLTGEAAISR 22 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;C9J0X3;C9K0F0;C9J760;Q96JY6-2;A0A087WXJ0 Q96JY6;A0A087WXJ0 PDLIM2 PDZ and LIM domain protein 2 1 AGS(1)PFSPPPSSSSLTGEAAISR 187.75 1.253e-21 6164300.0 26706.0 23723.0 23028.0 24733.0 27857.0 18424.0 20577.0 19553.0 20971.0 27329.0 True False 25221.787432588433 25542.47781853231 21546.403550990664 21364.322733195204 24357.354615260254 20961.738763579942 21533.871272551987 19609.895992826598 25165.78597869743 26539.940760730537 0.9503332226689635 0.9624165347168329 0.8118482156852252 0.8049875817660691 0.9177622073407294 0.7898185965281315 0.8113760112235928 0.7388824326933734 0.948223140570594 1.0 14.695877530050485 -5.254351619079108 24.10529527869985 0.8404114775063526 0.9563749050268504 0.21252071752683177 0.07676558490275949 422.41939961150047 1436620.7197594594 0.01856668059172698 0.0468665838030465 5.567348156159071e-06 5.254351619079108 0.11596342752049782 AGS(ph)PGEEQAHSCSTLSLLSEK ddPTM_A459_Selumetinib_30min_R2 1 AGSPGEEQAHSCSTLSLLSEK 21 0 Q9NZ71-9;A0A0C4DGC7;Q9NZ71-5;Q9NZ71-8;Q9NZ71-4;Q9NZ71;Q9NZ71-7;Q9NZ71-6;Q9NZ71-2 Q9NZ71-9 RTEL1 Regulator of telomere elongation helicase 1 1 AGS(0.998)PGEEQAHS(0.002)CSTLSLLSEK 98.76 0.00021190000000000005 2776100.0 10496.0 10078.0 11627.0 13433.0 13043.0 9002.2 10850.0 8886.4 10715.0 9331.0 True False 9912.674338817056 10850.95019412253 10878.931478520428 11603.40222678249 11404.42173410056 10242.171336164753 11354.546498867128 8912.25795277728 12858.299402114493 9061.589785150443 1.0939222116478189 1.1974664988592152 1.2005543990027145 1.2805040287519311 1.2585453551196282 1.1302841531128425 1.253041328076254 0.9835203495287461 1.418989350321933 1.0 13.14554846671571 AGS(ph)PINLSQHSLVIK ddPTM_A459_Selumetinib_30min_R1 2 AGSPINLSQHSLVIK 15 0 P48552 P48552 NRIP1 Nuclear receptor-interacting protein 1 1 AGS(1)PINLSQHSLVIK;AGS(0.99)PINLS(0.01)QHSLVIK 105.01 0.0032 18004000.0 6650.0 7037.400000000001 7033.2 8142.2 9311.9 6736.200000000001 8082.2 6101.099999999999 2596.44 4484.299999999999 True False 6804.932061352503 6213.457936401501 6078.130070602209 6720.317618023391 8469.640289149474 6668.439943980235 7472.553146983447 5939.279008834196 4405.969043525436 5059.903585780946 1.3448738589556009 1.2279795120725636 1.201234364955614 1.3281513183192752 1.6738738486935556 1.3178986182107315 1.4768172990454584 1.173792920783001 0.870761461919322 1.0 12.30489417992932 -8.031628592000995 4.050347486209261 0.9460137203882582 1.3633339265362239 0.638869067284705 0.12951584446345757 0.1503262061924852 5.3548829413781345 0.09772083978084385 0.03670385001777071 9.29761177264214e-09 8.031628592000995 0.4173202061479657 AGS(ph)PINLSQHSLVIK ddPTM_A459_Selumetinib_30min_R2 2 AGSPINLSQHSLVIK 15 0 P48552 P48552 NRIP1 Nuclear receptor-interacting protein 1 1 AGS(1)PINLSQHSLVIK;AGS(1)PINLSQHSLVIK 133.95 0.00032642 15546500.0 103224.0 90411.0 130621.0 170356.0 160830.0 106527.0 82752.0 92709.0 93213.0 132124.0 True False 97487.22331841192 97345.23298281511 122216.98706939156 147153.21891950816 140625.09756155752 121200.12729417492 86600.13196997714 92978.76784119886 111858.20458882887 128309.23682062136 0.7597833619313069 0.7586767359461853 0.9525190087464485 1.146863800033594 1.0959857688044232 0.9445939380312495 0.6749329519514304 0.724645942452178 0.871786064359565 1.0 16.969265506404817 -7.153663091814191 9.489137867786361 0.7950548213322888 0.9518248943707185 0.14924240082049833 0.1415279979106262 0.6624682056440807 53.82503479062434 0.059712273071124235 0.046246512462457014 7.01999670341997e-08 7.153663091814191 0.1567700730384297 AGS(ph)PLCNSNLQDSEEDIEPSYSLFR ddPTM_A459_Selumetinib_30min_R1 2 AGSPLCNSNLQDSEEDIEPSYSLFR 25 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 AGS(0.999)PLCNS(0.001)NLQDSEEDIEPSYSLFR;AGS(0.999)PLCNS(0.001)NLQDSEEDIEPSYSLFR 238.35 4.4301999999999996e-45 44640000.0 3950.0 4451.6 4709.7 4789.1 3608.3 3733.5 3731.3999999999996 3520.1000000000004 1934.75 2948.3 True False 4042.0273146379527 3930.4046025073067 4070.1486085302895 3952.7735875409417 3281.9299020971084 3695.9443797467725 3449.9374938326264 3426.7355131037457 3283.1294414509225 3326.7430238739503 1.2150103827169263 1.181457231382543 1.223463483449543 1.1881812208440394 0.986529430901261 1.1109798241773696 1.0370315558113707 1.0300571725895904 0.9868900055970539 1.0 11.699894713401276 -6.212892038664561 7.156168664218871 1.0316981770049525 1.2029307091204993 0.855920224276172 0.03547903771412692 0.09517367332707234 12.017359264992153 0.010504516011378301 0.013522666819728656 6.12502634929906e-07 6.212892038664561 0.1712325321155468 AGS(ph)PLCNSNLQDSEEDIEPSYSLFR ddPTM_A459_Selumetinib_30min_R2 2 AGSPLCNSNLQDSEEDIEPSYSLFR 25 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 AGS(0.994)PLCNS(0.006)NLQDSEEDIEPSYSLFR;AGS(0.978)PLCNS(0.022)NLQDSEEDIEPSYSLFR 196.75 4.231399999999999e-31 8602000.0 22570.4 22400.4 26302.0 24607.6 24370.2 20253.3 24843.4 23985.4 19833.7 22944.2 True False 21316.027524469937 24118.43865136162 24609.75795545233 21256.002429522265 21308.597603647744 23043.0082338479 25998.667326263178 24055.193543003283 23800.994199880388 22281.741329809127 0.9566589616563212 1.0824306006593527 1.1044809106785884 0.953965047654754 0.9563255083273279 1.0341655031700925 1.166814879566053 1.079592173113579 1.0681837585125702 1.0 14.44357436400982 -7.017753305294448 24.569520496214217 1.0874532200666809 1.014647530171802 0.2088026278395687 0.06122950579520997 937.2118683163262 1297043.268367816 0.02396295767281751 0.018985047321922063 9.599457599943088e-08 7.017753305294448 -0.07280568989487879 AGS(ph)PNTPPPR ddPTM_A459_Selumetinib_30min_R2 2 AGSPNTPPPR 10 0 Q1RMZ1 Q1RMZ1 C7orf60 Probable methyltransferase BTM2 homolog 1 AGS(0.983)PNT(0.017)PPPR;AGS(0.844)PNT(0.156)PPPR 89.9 0.032646 8200100.0 75940.0 76425.0 90084.0 85313.0 90238.0 59222.0 63659.0 68985.0 61888.0 78319.0 True False 71719.55881190614 82286.55175489318 84288.09351604315 73693.22222686622 78901.49570204454 67379.29293621004 66619.26963791535 69185.73492891851 74267.32929519952 76057.72697280005 0.9429621639567886 1.0818960154347066 1.1082121024493208 0.9689117090393795 1.0373896097402633 0.8858967473522629 0.8759040309177251 0.9096476805527054 0.9764600159791679 1.0 16.214807203423682 -6.752068954608142 24.99796423436683 0.920579820351793 1.0320630565928717 0.41768922678012277 0.05743340197104906 178.63423785405797 476551.0646988513 0.019289818321258107 0.019039364483292673 1.7698279336085087e-07 6.752068954608142 0.1114832362410787 AGS(ph)PSRDVGPSLGLK ddPTM_A459_Selumetinib_30min_R1 2 AGSPSRDVGPSLGLK 15 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 AGS(0.942)PS(0.04)RDVGPS(0.018)LGLK;AGS(0.958)PS(0.042)RDVGPSLGLK 157.83 0.00071852 49931400.0 3303.1000000000004 2536.1 6243.8 6285.799999999999 5118.4 3625.6000000000004 3591.6000000000004 4124.0 2136.6 2823.7 True False 3380.055803286235 2239.172232999098 5395.926254738396 5188.103029079543 4655.441623726918 3589.129755781412 3320.682720386253 4014.61812336009 3625.654148910216 3186.1494001671717 1.0608591684711612 0.7027831880330573 1.6935571993125247 1.6283301181066188 1.461149820370211 1.1264788008977533 1.042224423064412 1.2600219321634605 1.1379422913187889 1.0 11.637598201816221 -6.804451600454852 21.081679356542583 1.1251387768897976 1.3147057238828568 0.11356246830933381 0.2726014598373336 78.72344343121513 38582.598553490694 0.10712570678253237 0.09447902120046886 1.5687307136763014e-07 6.804451600454852 0.1895669469930592 AGS(ph)PSRDVGPSLGLK ddPTM_A459_Selumetinib_30min_R2 2 AGSPSRDVGPSLGLK 15 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 AGS(0.995)PS(0.005)RDVGPSLGLK;AGS(0.973)PS(0.027)RDVGPSLGLK 160.64 0.00060427 20372800.0 100325.0 134482.0 125025.0 138495.0 117796.0 108711.0 70183.0 70406.0 54935.9 129392.0 True False 94749.33813279544 144796.3369722155 116981.02761692778 119631.7420827994 102997.41337039879 123684.95346979692 73446.64856497613 70610.86980365922 65924.61503729547 125656.11675920998 0.7540368155285267 1.1523222323484912 0.9309616645331644 0.952056654050874 0.8196768770737106 0.9843130335374733 0.5845051594720148 0.5619373861359104 0.5246431032372606 1.0 16.93912137568634 -7.261393156802016 24.99999999450175 0.6312661841322716 0.9379599720134221 0.3932077679595214 0.15826948423129814 3.668780484237872 1985002.2120278266 0.06006450559420055 0.043472561947681045 5.4778084699547785e-08 7.261393156802016 0.3066937878811504 AGS(ph)SPAQGAQNEPPR ddPTM_A459_Selumetinib_30min_R1 3 AGSSPAQGAQNEPPR 15 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 AGS(0.5)S(0.5)PAQGAQNEPPR;AGS(0.607)S(0.393)PAQGAQNEPPR;AGS(0.615)S(0.385)PAQGAQNEPPR 167.92 6.959e-05 4705600.0 4746.4400000000005 5374.6 6018.93 6142.6 6349.83 4951.62 6280.41 5409.370000000001 2787.41 4165.4 True False 4857.022817035483 4745.339333416247 5201.592365615906 5069.910220882625 5775.4889976535405 4901.811198511242 5806.673617312898 5265.895935489901 4730.031185628487 4700.069664431898 1.033393792817868 1.009631701701558 1.1067053760882133 1.0786883137604366 1.2288092326290294 1.04292309443965 1.235444159744121 1.120386783910871 1.0063746972567928 1.0 12.198466425236528 -5.289397902320982 6.95607099945344 1.1131908664806502 1.0214131534453224 0.13918153637632735 0.07683611936052377 0.2890825793869576 55.17378595249973 0.01945868086051007 0.042395720721357326 5.13572898442829e-06 5.289397902320982 -0.09177771303532789 AGS(ph)SPAQGAQNEPPR ddPTM_A459_Selumetinib_30min_R2 1 AGSSPAQGAQNEPPR 15 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 AGS(0.5)S(0.5)PAQGAQNEPPR 169.15 6.1281e-05 4728100.0 9340.8 11412.0 12554.0 12272.0 10817.0 9063.8 8352.4 9681.4 8634.4 12431.0 True False 8821.675730185052 12287.263704636463 11746.289307761714 10600.532429619198 9458.07175479305 10312.256177015634 8740.803149966612 9709.571271157953 10361.521265293275 12072.084730383149 0.7307499845476205 1.017824508281635 0.9730124970212087 0.878102884992156 0.7834663163843505 0.8542233100022599 0.7240508450017475 0.8042994634324262 0.8583042197521435 1.0 13.559387216410927 -6.014961045571769 8.534736272305393 0.8234237361010835 0.9195474156688912 0.08246986124694766 0.09661484234783485 0.3382062495073188 161.8397872973137 0.02709867841992912 0.036978965085956585 9.661375336653105e-07 6.014961045571769 0.09612367956780765 AGS(ph)SSPEPWARPSCTPQEGGCPRPK ddPTM_A459_Selumetinib_30min_R2 1 AGSSSPEPWARPSCTPQEGGCPRPK 25 2 Q86VE0 Q86VE0 MYPOP Myb-related transcription factor, partner of profilin 1 AGS(0.35)S(0.322)S(0.322)PEPWARPS(0.003)CT(0.003)PQEGGCPRPK 40.012 0.042027 4742100.0 13326.0 12186.0 14966.0 15999.0 16547.0 10185.0 10391.0 11771.0 8338.4 11498.0 True False 12585.39426820466 13120.627015834201 14003.103853748755 13819.908600185598 14468.21792794311 11587.89129977539 10874.202089375878 11805.251661206046 10006.312994362255 11166.022864608283 1.127115215579148 1.1750492699975756 1.2540816030507027 1.2376751120570462 1.2957360112347103 1.0377814410988049 0.9738652894794477 1.0572476703969376 0.8961393967836271 1.0 13.446827794982637 -6.886061157539076 5.418756670662759 0.9893105903013488 1.217904457499109 0.8009945248754611 0.05647085346469348 0.09501324217136861 4.1450244159911005 0.02069451670394391 0.018240293454620072 1.2999865004749308e-07 6.886061157539076 0.2285938671977601 AGS(ph)STPGDAPPAVAEVQGR ddPTM_A459_Selumetinib_30min_R2 1 AGSSTPGDAPPAVAEVQGR 19 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AGS(0.958)S(0.035)T(0.007)PGDAPPAVAEVQGR 191.41 5.7343e-16 0.0 18956.0 15043.0 23881.0 26055.0 26660.0 18515.0 16622.0 12986.0 16979.0 22808.0 True False 17902.501406880336 16196.749729131296 22344.522459666827 22506.264052618015 23310.73245657603 21065.273187564188 17394.95593586815 13023.787110051966 20375.274432898 22149.47377769921 0.8082585431399791 0.7312476084844369 1.0088060187761207 1.0161082957771228 1.0524282739414788 0.9510507291949016 0.7853439820038497 0.5879953285014259 0.9198988037996852 1.0 14.434984803507085 -7.265299865040681 23.673776275364787 0.7889757884158132 0.9323767574538164 0.1036870455494372 0.13621679220000135 284.90435851967993 1747109.1804341634 0.05805268677178194 0.04086317843467822 5.428753657410626e-08 7.265299865040681 0.14340096903800326 AGSALPGFANSPAGS(ph)TSVVLVPPAHGTLVPDGNK ddPTM_A459_Selumetinib_30min_R2 1 AGSALPGFANSPAGSTSVVLVPPAHGTLVPDGNK 34 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 AGSALPGFANS(0.134)PAGS(0.344)T(0.261)S(0.261)VVLVPPAHGTLVPDGNK 85.93700000000003 1.2826e-08 6008300.0 36420.0 27649.0 53206.0 64539.0 65373.0 48022.0 39302.0 44556.0 45921.0 54633.0 True False 34395.922200811474 29769.58939445264 49782.783886312725 55748.676864015106 57160.259297964905 54636.594599687145 41129.62087543558 44685.6505833571 55106.48313994396 53055.60333641887 0.6482995204617933 0.5611017031638946 0.9383134062324462 1.0507594553306612 1.07736517358061 1.0297987613719781 0.7752172869402287 0.8422418702886298 1.0386552913274913 1.0 15.695217505407077 -5.287257435675376 7.291542318659069 0.9660270203421611 0.6043454560142131 0.7110727605897913 0.0928981435816914 0.10491157390348413 23.893617815054938 0.02708615961232136 0.05893350400889232 5.161103451163939e-06 5.287257435675376 -0.36168156432794807 AGSATVLSGS(ph)IAGLEGGSQLALR ddPTM_A459_Selumetinib_30min_R1 1 AGSATVLSGSIAGLEGGSQLALR 23 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 AGSATVLS(0.001)GS(0.999)IAGLEGGSQLALR 273.8 3.158099999999998e-66 26147000.0 825.41 1291.9 1064.8 1073.4 719.26 792.02 899.42 562.1 441.3 463.37 True False 844.6404470317245 1140.643747411985 920.2060085277307 885.9508402134943 654.2030599956665 784.052997896622 831.5760252728036 547.191282041878 748.8538687232417 522.8480531060184 1.6154606333791894 2.18159700631169 1.7599874438877172 1.6944709556637658 1.2512297905850922 1.4995809838802991 1.5904735999928916 1.0465588975444144 1.4322590746482056 1.0 9.030247929974449 -6.191069510605345 0.2974420526768569 1.0234940677038016 2.213333122266839 0.5891630517353483 0.21384395383042354 2.338974046056855 0.3283346677361109 0.27981501590957236 0.9687007108831331 6.440661718441565e-07 6.191069510605345 1.1898390545630373 AGSCCLS(ph)PGGR ddPTM_A459_Selumetinib_30min_R1 2 AGSCCLSPGGR 11 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 AGSCCLS(1)PGGR;AGSCCLS(1)PGGR 126.71 0.0031068000000000003 26321000.0 4903.5 5209.3 5050.2 5572.299999999999 5121.6 4306.2 5316.799999999999 5103.8 3100.2 4051.0 True False 5017.7420094499275 4599.392734262131 4364.410578762909 4599.20241002576 4658.352184291924 4262.883537716767 4915.74949541976 4968.430644521146 5260.8129703507675 4570.985310081529 1.0977375049495466 1.006214726640654 0.9548073954945754 1.0061730891766372 1.0191133570299826 0.9325962015924163 1.0754244789581444 1.0869495978390111 1.1509144338634802 1.0 12.158289467177305 -7.4379272056562264 9.172174478048062 1.0876257230990463 1.0016750490984754 0.3234105438445548 0.05312882927766225 0.429783403175783 43.65642532899349 0.02193236700248052 0.014750597163513861 3.648150903448708e-08 7.4379272056562264 -0.08595067400057088 AGSCCLS(ph)PGGR ddPTM_A459_Selumetinib_30min_R2 1 AGSCCLSPGGR 11 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 AGSCCLS(1)PGGR 125.36 0.0033649 14104000.0 17394.0 19507.0 19751.0 22012.0 25909.0 13022.0 14366.0 17911.0 17228.0 22294.0 True False 16427.311113698925 21003.124175108973 18480.24216326284 19013.927627182027 22654.079790601198 14815.66229805352 15034.047465688956 17963.118044674324 20674.08139053929 21650.314293231608 0.7587562421130526 0.9701071259586767 0.8535784706386546 0.8782287115862435 1.0463626293722392 0.6843162689183334 0.6944031972038831 0.8296931768002099 0.9549090655465675 1.0 14.402100347965442 -3.6081782188086775 15.417839595213977 0.8602156259509901 0.2798386805778281 0.0 0.12052462913220646 0.0 0.0 0.028050550001419965 0.0 0.00024650275711468025 3.6081782188086775 -0.580376945373162 AGSFTGTS(ph)DPEAAPAR ddPTM_A459_Selumetinib_30min_R1 1 AGSFTGTSDPEAAPAR 16 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 AGSFT(0.005)GT(0.058)S(0.936)DPEAAPAR 101.2 0.0082759 0.0 1150.0 1251.3 1473.2 1303.6 1091.5 1435.3 1324.0 1167.1 760.04 968.59 True False 1176.7927624895306 1104.7972142864119 1273.1475317083525 1075.9507316026738 992.7740177199771 1420.8621851481298 1224.1296140414845 1136.1447167249175 1289.7323688747174 1092.9179613655572 1.0767439131654266 1.0108692997469015 1.16490676950501 0.9844752942465294 0.9083701181738708 1.3000629831106623 1.1200562689188343 1.0395516927046842 1.1800815930074464 1.0 10.09396939548607 -6.743774940610467 24.999441414789644 1.1299291936997524 1.0331304833966828 0.20515223898704038 0.0971098218330435 423.8763890712493 599886.3586192941 0.03221909932732926 0.03215379471635414 1.8039523399623816e-07 6.743774940610467 -0.09679871030306963 AGSGLVLSGSEIPKETLS(ph)PPGNGCAIYR ddPTM_A459_Selumetinib_30min_R1 1 AGSGLVLSGSEIPKETLSPPGNGCAIYR 28 1 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;Q6W2J9-3 H7BYY2 BCOR BCL-6 corepressor 1 AGSGLVLS(0.001)GS(0.001)EIPKET(0.243)LS(0.739)PPGNGCAIY(0.015)R 48.51 0.019783 9964000.0 732.01 660.32 1202.1 1175.2 734.6 839.21 662.35 711.85 584.82 649.43 True False 749.064408756488 583.00942742556 1038.8614226626453 969.9733812361634 668.1555597041641 830.7683093417141 612.3884062389554 692.969425585325 992.3968264371774 732.7906664838927 1.0222079005873268 0.7956016009633156 1.4176782950134372 1.3236704909061285 0.911795947006444 1.1337048182231113 0.8356935128245335 0.9456580948422287 1.3542705602391718 1.0 9.517257317795886 -6.290984167708635 24.98727197223722 1.0229212842115185 1.1350540478563196 0.06347434715917655 0.20478727630944718 2305.177004551728 1949579.070764436 0.06677795398888331 0.07573070982729141 5.117004893429904e-07 6.290984167708635 0.11213276364480107 AGSIS(ph)PGSPPYPQSR ddPTM_A459_Selumetinib_30min_R1 1 AGSISPGSPPYPQSR 15 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5 Q63HR2-6 TNS2 Tensin-2 1 AGS(0.161)IS(0.837)PGS(0.002)PPYPQSR 136.33 0.00059494 0.0 1224.6 1613.9 1516.0 1907.4 1691.3 1295.6 1549.4 1665.7 1030.7 1078.7 True False 1253.1307973431994 1424.943837718245 1310.135526791924 1574.30839633242 1538.3222136232673 1282.5674403106789 1432.527510570904 1621.5202250438647 1749.0226206504535 1217.1616524277836 1.0295516580264181 1.1707104268985253 1.0763858064199543 1.2934258922734394 1.2638602362758375 1.0537363198655127 1.1769410478168991 1.3322143544446512 1.436968226169306 1.0 10.249305071175897 -3.1226927671722486 0.5305392987037567 1.2337751890912023 6.953193785173319e-13 0.15368855618511612 0.12707143800883883 40.5115403243735 2.139320537501912 0.06845948184385035 45.39928256503757 0.0007538886984116312 3.1226927671722486 -1.233775189090507 AGSIS(ph)PGSPPYPQSR ddPTM_A459_Selumetinib_30min_R2 2 AGSISPGSPPYPQSR 15 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5 Q63HR2-6 TNS2 Tensin-2 1 AGS(0.007)IS(0.941)PGS(0.051)PPYPQSR;AGS(0.011)IS(0.959)PGS(0.029)PPYPQSR 160.87 4.1081e-05 0.0 21981.2 20419.1 27567.0 28808.0 28038.6 20901.5 18454.0 20476.2 21494.2 23294.6 True False 20759.572901715455 21985.179312245225 25793.36923268019 24884.300703428107 24516.140399735657 23780.491900074176 19312.14756590728 20535.782351982598 25793.640598126876 22622.024371360592 0.9176708751139445 0.9718484496055264 1.1401883761266967 1.1000032665039274 1.083728847484269 1.0512097197711536 0.8536878596221651 0.9077782790288579 1.1402003717572482 1.0 14.465440416739414 -7.112193247846545 22.682986536884275 0.9655448446082158 1.049553351610792 0.11484140447203339 0.09105117770955742 23.344773763461724 4684.1814852305915 0.036481485287503376 0.028258453768490437 7.723368421997945e-08 7.112193247846545 0.08400850700257623 AGSISPGS(ph)PPYPQSR ddPTM_A459_Selumetinib_30min_R1 1 AGSISPGSPPYPQSR 15 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5 Q63HR2-6 TNS2 Tensin-2 1 AGSIS(0.005)PGS(0.995)PPYPQSR 188.0 2.4421e-05 11331000.0 971.73 1397.4 1527.2 1112.5 1422.7 1087.1 1071.0 1228.0 638.61 1115.7 True False 994.3694183425672 1233.7917583663655 1319.81462830912 918.2227592113954 1294.0170361980863 1076.1647610078262 990.2136077329537 1195.4294508938374 1083.6745277710158 1258.910962838302 0.7898647701825492 0.9800468776478809 1.0483780563269594 0.7293786346424361 1.027886065334307 0.8548378660406118 0.7865636545895577 0.9495742639325808 0.8608031542816947 1.0 10.29796053593665 -3.40494006514265 14.61120367895317 0.9016295763674455 0.3005624596432438 0.0 0.10717215585452664 0.0 0.0 0.023381770810533005 0.0 0.000393604391124705 3.40494006514265 -0.6010671167242017 AGSLQLSSMSAGNS(ph)SLRR ddPTM_A459_Selumetinib_30min_R1 1 AGSLQLSSMSAGNSSLRR 18 1 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2;A0A0B4J1Z0 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 AGSLQLSSMSAGNS(0.625)S(0.375)LRR 108.96 0.00076078 7925700.0 888.39 1014.9 1227.2 1107.6 975.66 1030.3 817.29 776.92 464.4 885.72 True False 909.0877584939772 896.0750361857899 1060.552980527077 914.1784522270041 887.411725266764 1019.9361174375525 755.6411572960458 756.3135578081767 788.052881565995 999.4107896434001 0.9096237182093551 0.8966033241501411 1.0611782377349488 0.9147174132002239 0.8879349057091944 1.0205374286598168 0.7560866513815268 0.7567594483125774 0.7885174842340658 1.0 9.964933983274781 -7.26753535525413 24.99818347472029 0.8050708476027224 0.9469190443917682 0.3317229707013908 0.08361719775389691 507.34253772407067 2080484.0191131525 0.0332286486986487 0.023043675399986217 5.4008814521934e-08 7.26753535525413 0.1418481967890458 AGSLQLSSMSAGNS(ph)SLRR ddPTM_A459_Selumetinib_30min_R2 1 AGSLQLSSMSAGNSSLRR 18 1 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2;A0A0B4J1Z0 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 AGSLQLS(0.001)S(0.001)MS(0.224)AGNS(0.387)S(0.387)LRR 59.57899999999999 0.026884 5184800.0 28418.0 33846.0 35759.0 39135.0 41525.0 32065.0 22180.0 25594.0 18917.0 36455.0 True False 26838.641326267432 36441.879367957044 33458.30487145541 33804.74548835948 36308.258261789895 36481.66269291096 23211.413948836223 25668.47430268522 22700.9285851423 35402.449428534965 0.7581012545599469 1.0293603961364404 0.9450844619945268 0.95487024299263 1.0255860497755511 1.0304841411200811 0.6556442936439149 0.7250479759741144 0.6412248008705571 1.0 15.111561560652916 -7.26001959576743 24.99728103938137 0.73256659543713 0.9629709475400624 0.4034372741661594 0.11877748899965955 110.76139053207189 1950133.0399454702 0.04474998551996972 0.0327552244595456 5.495160786261321e-08 7.26001959576743 0.23040435210293242 AGSNEDPILAPS(ph)GTPPPTIPPDETFGGR ddPTM_A459_Selumetinib_30min_R1 1 AGSNEDPILAPSGTPPPTIPPDETFGGR 28 0 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 AGSNEDPILAPS(0.97)GT(0.03)PPPTIPPDETFGGR 159.89 1.4354e-17 49000000.0 6239.7 7461.7 7156.1 8819.7 8486.7 7278.2 7174.5 7121.8 4024.1 5458.2 True False 6385.072869657322 6588.08069514978 6184.340925643588 7279.504961273477 7719.07948344858 7204.987916076861 6633.321688776914 6932.906729133337 6828.603791364598 6158.8131373702845 1.0367375543372384 1.0696997210671642 1.004144920085074 1.1819655506518112 1.2533388026681556 1.1698662965366857 1.0770454535351006 1.1256887608857666 1.1087532027770375 1.0 12.588436641133235 -5.759604800923709 24.9999342573295 1.140663064835714 1.0401446245975603 0.2962864203730743 0.06520078278662635 58.90991985605474 802741.036446621 0.01861584278884334 0.030252089217741477 1.739382911604117e-06 5.759604800923709 -0.1005184402381536 AGSNEDPILAPS(ph)GTPPPTIPPDETFGGR ddPTM_A459_Selumetinib_30min_R2 1 AGSNEDPILAPSGTPPPTIPPDETFGGR 28 0 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 AGSNEDPILAPS(0.91)GT(0.09)PPPTIPPDETFGGR 94.957 9.6396e-07 4461800.0 27540.0 28836.0 29410.0 32770.0 35821.0 24024.0 24659.0 21690.0 24650.0 28997.0 True False 26009.437051354973 31047.628477646085 27517.792619186872 28306.6694685969 31320.845736196912 27333.087931841317 25805.692360881523 21753.114309027205 29580.68877854616 28159.78126674608 0.9236377514788991 1.1025521890083099 0.9772019306017362 1.005216240867051 1.112254581791931 0.9706427643356377 0.9164024434861466 0.7724887527700893 1.0504587552843683 1.0 14.781348507324152 -6.99834319621569 24.898901755797162 0.9198274040318717 1.0265227952988212 0.19121088002177955 0.08474364914624452 70.0054550637488 1052040.170584336 0.028877465716112025 0.025285306216338968 1.0038222178100862e-07 6.99834319621569 0.10669539126694949 AGSNEDPILAPSGT(ph)PPPTIPPDETFGGR ddPTM_A459_Selumetinib_30min_R1 3 AGSNEDPILAPSGTPPPTIPPDETFGGR 28 0 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 AGSNEDPILAPS(0.062)GT(0.938)PPPTIPPDETFGGR;AGSNEDPILAPS(0.031)GT(0.969)PPPTIPPDETFGGR;AGSNEDPILAPS(0.21)GT(0.789)PPPT(0.001)IPPDETFGGR 179.61 2.5098999999999998e-26 61629100.0 10128.42 12205.35 11583.710000000001 12396.72 11732.480000000001 10513.75 10370.33 9807.15 5701.11 8829.01 True False 10364.392479525402 10776.341947886727 10010.70580676442 10231.865567254916 10671.279255537587 10407.991220721211 9588.087658899416 9547.032523887212 9674.367277400326 9962.299435340146 1.0403614694373546 1.081712311282158 1.0048589556797054 1.0270586257384027 1.071166282924845 1.04473784273137 0.9624372085109933 0.958316158418224 0.9710978213605573 1.0 13.282263059192768 -7.257894530675631 24.40670131504117 0.9694891409543334 1.0452037600365727 0.7087473370496626 0.0225734509850462 117.58955439167644 809623.731632964 0.009039722683798565 0.006717982132930612 5.522115287242623e-08 7.257894530675631 0.07571461908223931 AGSNEDPILAPSGT(ph)PPPTIPPDETFGGR ddPTM_A459_Selumetinib_30min_R2 4 AGSNEDPILAPSGTPPPTIPPDETFGGR 28 0 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 AGSNEDPILAPS(0.014)GT(0.986)PPPTIPPDETFGGR;AGSNEDPILAPS(0.018)GT(0.982)PPPTIPPDETFGGR;AGSNEDPILAPS(0.067)GT(0.933)PPPTIPPDETFGGR;AGSNEDPILAPS(0.354)GT(0.646)PPPTIPPDETFGGR 132.99 3.6673e-12 57636000.0 299569.0 288277.0 325271.0 374923.0 375371.0 264426.0 263216.0 297823.0 249772.0 308388.0 True False 282920.15424972266 310386.91894334776 304343.41798828676 323857.84062175045 328213.5391206823 300848.28127976524 275456.0655526094 298689.6156227482 299733.37921277963 299484.03715174965 0.9446919339689748 1.0364055523469304 1.0162258425616015 1.0813859853827552 1.0959299942733685 1.0045553150043998 0.9197687735624948 0.9973473660347416 1.0008325721243823 1.0 18.192119582172914 -6.996786593812412 24.99126954816027 0.9768226816640976 1.037921034297192 0.26107209679040533 0.04382802597852058 128.61432110699096 1000250.720358055 0.016172805141205955 0.014193389907046617 1.007426582469308e-07 6.996786593812412 0.06109835263309449 AGSNMLLIGVHGPTT(ph)PCEEVSMK ddPTM_A459_Selumetinib_30min_R2 1 AGSNMLLIGVHGPTTPCEEVSMK 23 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 AGSNMLLIGVHGPT(0.228)T(0.772)PCEEVSMK 126.16 1.3237e-05 5357900.0 33315.0 40901.0 40460.0 30029.0 27176.0 34144.0 30213.0 28320.0 19801.0 33010.0 True False 31463.485670511636 44037.97518255658 37856.84764951721 25938.99839708564 23761.907923477476 38847.02607162798 31617.964365923755 28402.406511371624 23761.753286166026 32056.915529719878 0.9814882421030784 1.3737433703417006 1.1809260817504488 0.8091545293257446 0.7412412432957837 1.2118142194813788 0.9863071304103113 0.8859993558968526 0.7412364194595257 1.0 14.96834799767903 -5.726405096730186 11.670125729386632 0.9147186774233996 1.19849887457075 0.3732464729482915 0.15840887472451487 0.7841554566032449 257.89463444276777 0.04408818439663953 0.07608300535875778 1.8775646643390082e-06 5.726405096730186 0.2837801971473505 AGSPS(ph)RDVGPSLGLK ddPTM_A459_Selumetinib_30min_R1 1 AGSPSRDVGPSLGLK 15 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 AGS(0.123)PS(0.877)RDVGPSLGLK 106.54 0.0024523 45372000.0 4044.3 2604.8 7591.7 6772.3 5325.0 4467.1 3981.6 3869.4 2546.2 2791.0 True False 4138.524321162093 2299.828805061332 6560.788838223117 5589.644936815581 4843.3546902051075 4422.165029802278 3681.264706395448 3766.7709424174413 4320.715432909852 3149.2520366422 1.3141292830835718 0.7302777860591491 2.083284780604086 1.7749119066301788 1.5379380989046516 1.4041953385595918 1.1689330239571714 1.1960843078262016 1.3719814681827407 1.0 11.620793506556936 -7.117104046618316 3.6787949212790036 1.201036134001453 1.493732887435109 0.15544257897204505 0.33397042825081164 0.5506563729307546 13.384157081309315 0.14453162673685446 0.1104402047406668 7.636528086282068e-08 7.117104046618316 0.292696753433656 AGSQEAEVGS(ph)DGER ddPTM_A459_Selumetinib_30min_R2 1 AGSQEAEVGSDGER 14 0 J3KN78;Q9UK96 J3KN78 FBXO10 F-box only protein 10 1 AGSQEAEVGS(1)DGER 109.14 0.006458 0.0 8308.1 8519.0 9468.0 8978.2 10499.0 5528.8 7497.4 9632.5 7526.0 8835.8 True False 7846.369061959413 9172.379907097622 8858.83918797896 7755.353671741125 9180.021757749122 6290.342014550635 7846.043955816261 9660.52898025378 9031.410294009682 8580.687495834563 0.9144219581202997 1.0689562941839208 1.0324160147167023 0.9038149536975807 1.0698468814072883 0.7330813547986964 0.9143840699973131 1.1258455671463876 1.0525275857434406 1.0 13.06687752761955 -7.754588271820343 24.999265188014082 1.0668899375338092 0.9507261524500754 0.21329960840647755 0.09757373564525158 245.35684521849257 895301.3503639236 0.04883622908121894 0.027401673460217362 1.7595909846420355e-08 7.754588271820343 -0.11616378508373382 AGSRPQS(ph)PSGDADAR ddPTM_A459_Selumetinib_30min_R1 1 AGSRPQSPSGDADAR 15 1 O94819 O94819 KBTBD11 Kelch repeat and BTB domain-containing protein 11 1 AGS(0.004)RPQS(0.966)PS(0.03)GDADAR 122.16 0.007553499999999999 3129800.0 942.68 940.14 786.14 854.8 860.99 748.79 914.03 912.69 486.41 670.15 True False 964.6426098640263 830.0679717407718 679.386505957917 705.5252265832821 783.1136065201304 741.2578524469232 845.0839812102251 888.4824963650627 825.4022440191985 756.1702803137839 1.2756949525492245 1.0977262573666913 0.8984570322917157 0.9330242736999848 1.0356312948389956 0.9802790082404818 1.1175842309744641 1.1749767472960904 1.0915560496197838 1.0 9.562567338112707 -7.282256009424015 23.062208906143567 1.110610683360179 1.0285126045828974 0.06051911370958851 0.10539862439331 737.616297328656 817179.2050301504 0.046843627478347284 0.03163390921415193 5.2208833582000935e-08 7.282256009424015 -0.08209807877728159 AGSRPQS(ph)PSGDADAR ddPTM_A459_Selumetinib_30min_R2 3 AGSRPQSPSGDADAR 15 1 O94819 O94819 KBTBD11 Kelch repeat and BTB domain-containing protein 11 1 AGS(0.019)RPQS(0.93)PS(0.05)GDADAR;AGS(0.018)RPQS(0.963)PS(0.019)GDADAR;AGS(0.006)RPQS(0.929)PS(0.065)GDADAR 112.57 0.014122999999999997 4100130.0 13944.800000000001 9084.3 14200.999999999998 13171.6 16030.8 10390.4 10470.2 12879.3 9277.0 12691.8 True False 13169.803841457333 9781.03659937163 13287.32312087972 11377.605357722636 14016.867586829656 11821.58328533983 10957.085046307711 12916.776630717099 11132.659221037437 12325.35475674338 1.0685131666698635 0.7935703914745564 1.0780479250392394 0.9231057103243039 1.137238470086293 0.9591272234068614 0.888987397325252 1.0479841664314078 0.9032323564517766 1.0 13.589341551380121 -5.304204229144229 24.999871638830435 0.9917718534208322 0.9310406378799475 0.059979889228580996 0.09685712294116124 1226.3605515404765 716915.0391374498 0.023897204205787916 0.049746373536131774 4.963588513361708e-06 5.304204229144229 -0.060731215540884675 AGSS(ph)PAQGAQNEPPR ddPTM_A459_Selumetinib_30min_R1 2 AGSSPAQGAQNEPPR 15 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 AGS(0.144)S(0.856)PAQGAQNEPPR;AGS(0.309)S(0.691)PAQGAQNEPPR 93.716 0.012186 7135100.0 1629.25 1871.1599999999999 2363.04 2071.06 1730.3 1928.92 1684.6599999999999 1619.84 1490.5700000000002 1345.01 True False 1667.208355031364 1652.0837173213163 2042.152147249595 1709.3882496111041 1573.794670509277 1909.516816119231 1557.584739872452 1576.8765812181387 2529.388423074559 1517.6551350068528 1.098542295001582 1.088576501481581 1.3455969674166943 1.126335100894569 1.0369909699558792 1.2582020592646752 1.0263100647469683 1.039021675507999 1.6666424174574666 1.0 10.567628281252162 AGSS(ph)PAQGAQNEPPR ddPTM_A459_Selumetinib_30min_R2 2 AGSSPAQGAQNEPPR 15 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 AGS(0.042)S(0.958)PAQGAQNEPPR;AGS(0.193)S(0.807)PAQGAQNEPPR 116.0 0.0028921 5241500.0 25583.0 20522.4 28973.2 30920.0 32332.3 31780.7 21927.3 24762.8 28164.5 28512.0 True False 24161.199276863266 22096.40209008336 27109.09585563498 26708.642660024907 28270.427419570606 36158.20294852938 22946.962898120666 24834.85564829777 33798.18698188087 27688.784476927412 0.8725987699819896 0.798027161809718 0.9790641361748661 0.9646014862906228 1.021006445520491 1.305879027613487 0.8287457658981735 0.8969283454458692 1.2206453847782417 1.0 14.757014101091055 -5.522505481822962 1.7269639210887837 1.0370786830761418 0.8307629178533918 0.25253567598355553 0.13396197025300344 0.5777752361452615 3.3176825089896687 0.04144596619798944 0.11959525415184641 3.00257952097092e-06 5.522505481822962 -0.20631576522274997 AGSS(ph)TPGDAPPAVAEVQGR ddPTM_A459_Selumetinib_30min_R1 1 AGSSTPGDAPPAVAEVQGR 19 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AGS(0.078)S(0.461)T(0.461)PGDAPPAVAEVQGR 242.1 5.7133e-30 21767000.0 1826.7 2365.3 2072.1 2451.8 2220.5 1865.6 1717.5 1998.6 904.17 1668.4 True False 1869.258555860543 2088.369576401863 1790.720201230569 2023.639155986068 2019.6561670611163 1846.8337578292696 1587.947592232818 1945.5906356322675 1534.3104520360157 1882.555391592206 0.9929368156756244 1.109327027363368 0.9512178017328002 1.0749426896143215 1.0728269542990472 0.9810249228668251 0.8435064377520292 1.0334838721461197 0.8150147713520102 1.0 10.878476599492732 -6.995520715917315 7.336545705407782 0.9237686533475445 1.0399468271981294 0.364490599039089 0.07302552229798626 0.13553213184578014 47.79177837790354 0.02460160330816838 0.020864411069338205 1.0103673046942339e-07 6.995520715917315 0.11617817385058482 AGSS(ph)TPGDAPPAVAEVQGR ddPTM_A459_Selumetinib_30min_R2 1 AGSSTPGDAPPAVAEVQGR 19 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AGS(0.008)S(0.908)T(0.084)PGDAPPAVAEVQGR 245.18 1.5159999999999999e-30 35312000.0 45793.0 48178.0 52802.0 59661.0 70458.0 41324.0 44890.0 49278.0 44008.0 52881.0 True False 43248.008383903354 51873.09768331369 49404.77680647076 51535.06887903444 61606.43613748813 47016.005898077376 46977.47394784752 49421.390821587964 52810.82968625805 51354.18812866157 0.8421515354414876 1.0101045226019747 0.962039876527562 1.0035222200362646 1.199638011667925 0.9155242758445443 0.9147739582631754 0.9623633947394666 1.0283646107683961 1.0 15.64819431813892 -4.758802684644977 24.861051811667895 0.9983392055406664 0.842151312573554 0.2775083777691336 0.07618670878754256 97.52607189974177 919362.9894032998 0.0198933984215242 0.13229260109027907 1.742598417705297e-05 4.758802684644977 -0.15618789296711233 AGSSPCLGSSSAASS(ph)PPPPASR ddPTM_A459_Selumetinib_30min_R1 2 AGSSPCLGSSSAASSPPPPASR 22 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 AGSSPCLGS(0.002)S(0.099)S(0.099)AAS(0.23)S(0.571)PPPPASR;AGSSPCLGSSSAAS(0.094)S(0.906)PPPPASR 283.64 1.2612999999999996e-78 20545400.0 1609.0 1697.5900000000001 1959.48 2171.7 2171.1 1974.4099999999999 1761.1599999999999 1569.8000000000002 978.98 1326.5900000000001 True False 1646.486569431004 1498.8353736118204 1693.3933786531902 1792.4533628578765 1974.7243883388364 1954.5492280208452 1628.3142832819485 1528.163804570967 1661.2575581297963 1496.8707485808595 1.099952398022335 1.0013124880907878 1.131288977527718 1.1974670254978597 1.3192350710380414 1.3057568463235036 1.0878122141311846 1.0209056500167268 1.1098203099397774 1.0 10.547733937967676 -7.5075356736606915 23.819573418232114 1.0500895329990478 1.1753296341204853 0.3058785263820021 0.09112727192245137 563.6466969240356 875048.2908982864 0.04554213408052005 0.029530375780659916 3.107880605846589e-08 7.5075356736606915 0.12524010112143746 AGSSPCLGSSSAASS(ph)PPPPASR ddPTM_A459_Selumetinib_30min_R2 2 AGSSPCLGSSSAASSPPPPASR 22 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 AGSSPCLGSS(0.001)S(0.001)AAS(0.087)S(0.911)PPPPASR;AGSSPCLGSSSAAS(0.315)S(0.684)PPPPASR 188.34 1.1865e-21 15516600.0 19519.9 16036.2 19565.0 26416.0 30442.0 20753.0 21258.9 20907.6 19493.8 22421.9 True False 18435.062102350905 17266.12497548994 18306.20920076134 22818.095229858278 26617.603805067047 23611.537373022948 22247.480973711183 20968.43765456049 23393.104702280867 21774.521487907503 0.8466345454520703 0.7929508340781999 0.8407169457628589 1.0479263685555764 1.222419689904513 1.0843653848437327 1.0217207751759936 0.9629804111289118 1.074333813272188 1.0 14.41035339437321 -5.757016107603792 5.074004487132354 1.0650180483504421 0.8200477242066442 0.7243397360939137 0.06576379944808385 0.09703920577917258 6.981037691288102 0.020191488766808447 0.033298993052516566 1.749781789539719e-06 5.757016107603792 -0.24497032414379794 AGSST(ph)PGDAPPAVAEVQGR ddPTM_A459_Selumetinib_30min_R1 3 AGSSTPGDAPPAVAEVQGR 19 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AGSS(0.004)T(0.996)PGDAPPAVAEVQGR;AGSS(0.004)T(0.996)PGDAPPAVAEVQGR;AGSS(0.081)T(0.919)PGDAPPAVAEVQGR 281.49 2.3649e-71 54243000.0 8891.3 9590.2 11034.1 11188.4 10576.8 9119.8 10049.2 9408.8 4767.6 7129.700000000001 True False 9098.44999054188 8467.37492563698 9535.729825972798 9234.555972279351 9620.1303074857 9028.06309211588 9291.180753342669 9159.248059910373 8090.26898827312 8044.866444159049 1.1309634602011052 1.0525190174890586 1.1853185994027515 1.1478818245620563 1.1958098216124355 1.1222141666094008 1.1549204474473909 1.138520834806452 1.0056436666076707 1.0 12.973852755088895 -8.263508309971462 5.960117189030272 1.0008272719650686 1.1416871880537725 0.6938244409548916 0.03673357664840238 0.08447652485697173 13.617572497679964 0.031082279710465177 0.009613477427897919 5.4511946504628095e-09 8.263508309971462 0.14085991608870385 AGSST(ph)PGDAPPAVAEVQGR ddPTM_A459_Selumetinib_30min_R2 3 AGSSTPGDAPPAVAEVQGR 19 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 AGS(0.002)S(0.044)T(0.954)PGDAPPAVAEVQGR;AGSS(0.03)T(0.97)PGDAPPAVAEVQGR;AGSS(0.004)T(0.996)PGDAPPAVAEVQGR 224.36 2.0253e-19 59428000.0 83823.0 72435.0 98089.0 97263.0 113913.0 82690.0 79849.0 84311.0 73959.0 98952.0 True False 79164.4532300554 77990.53158476546 91778.06053122827 84015.61161196635 99602.23054485908 94079.79691491678 83562.13671779177 84556.33105156253 88752.86658711951 96094.99865182795 0.8238144996170361 0.8115982379826163 0.9550763496418702 0.8742974430581167 1.0364975486990593 0.9790290674313586 0.8695784160480055 0.8799243689874809 0.9235950656359286 1.0 16.552173726178353 -5.257396150759457 24.71954516400781 0.935475773414153 0.8177063529800491 0.4579326875719125 0.05294981292006282 275.51756894520753 1684443.8672715295 0.01430289951201256 0.0350840350518265 5.528455895245601e-06 5.257396150759457 -0.11776942043410388 AGT(ph)EDEEEEEEGRR ddPTM_A459_Selumetinib_30min_R1 2 AGTEDEEEEEEGRR 14 1 F8WBH7;O95456-2;O95456 F8WBH7 PSMG1 Proteasome assembly chaperone 1 1 AGT(1)EDEEEEEEGRR;AGT(1)EDEEEEEEGRR 162.79 0.00034072 13413100.0 1305.18 1757.56 1618.94 1239.52 1253.48 1393.37 1464.3400000000001 1250.42 1039.34 1444.2199999999998 True False 1335.5881545618138 1551.7840581325222 1399.0968402008675 1023.0611006720978 1140.1029553198687 1379.3539628787355 1353.883654853102 1217.254799663415 1763.6840696098218 1629.5997048940867 0.8195805083608666 0.9522486126329889 0.8585524629140747 0.6277990218086043 0.6996214787569367 0.8464372929966777 0.8308074987906895 0.7469655253420218 1.082280552894706 1.0 10.670301908819397 -8.26296131548501 24.996056531794444 1.0411403015631002 0.7987167834389272 0.5549961767507106 0.08717264381285586 112.0990222045491 1841002.5853301398 0.07804120713129202 0.02424117368029785 5.4580647630364954e-09 8.26296131548501 -0.24242351812417307 AGT(ph)EDEEEEEEGRR ddPTM_A459_Selumetinib_30min_R2 3 AGTEDEEEEEEGRR 14 1 F8WBH7;O95456-2;O95456 F8WBH7 PSMG1 Proteasome assembly chaperone 1 1 AGT(1)EDEEEEEEGRR;AGT(1)EDEEEEEEGRR;AGT(1)EDEEEEEEGRR 180.3 0.00047988 28040700.0 45437.0 36446.0 37189.8 42217.0 39409.9 34441.5 37995.2 35631.2 30106.800000000003 40727.3 True False 42911.79343872241 39241.29100763936 34797.048757192664 36466.97177161293 34458.876033023844 39185.50399619184 39762.05208606051 35734.880892937275 36129.00125427723 39551.39702676648 1.0849627741260763 0.9921594167984192 0.8797931646673239 0.9220147583392274 0.8712429553298393 0.9907489227162565 1.0053261091928427 0.9035048969004466 0.9134696615097279 1.0 15.271441033741633 -4.894573504591481 3.3900990893345844 0.9338765817646089 1.0883953677175962 0.495334184953665 0.04616234678444781 0.22396593091223602 4.460665494717627 0.012196397494855682 0.07623488679287456 1.2747543287793495e-05 4.894573504591481 0.1545187859529873 AGT(ph)GYASPDRTHVLAAGK ddPTM_A459_Selumetinib_30min_R1 1 AGTGYASPDRTHVLAAGK 18 1 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 AGT(0.871)GY(0.001)AS(0.114)PDRT(0.014)HVLAAGK 66.325 0.017967 22634000.0 5792.4 5847.9 7993.4 8127.7 7355.9 5769.4 6113.0 6617.3 3326.9 4664.8 True False 5927.351649951616 5163.225149385049 6907.940184603268 6708.349770824681 6690.560143789627 5711.365074196069 5651.891488395464 6441.787707980287 5645.506312837874 5263.5725189998375 1.1261081002599937 0.9809355016478701 1.3124052456136552 1.2744860542169132 1.271106291333275 1.0850738834849984 1.0737747923095802 1.223843251846054 1.072561704519008 1.0 12.36182661002666 -6.7900395540829885 24.99094912947979 1.1039611504242657 1.192386183130249 0.19493524488559288 0.10192130579360459 454.7155552590258 397329.3375005393 0.03866089807696697 0.03410155165406506 1.62166239506775e-07 6.7900395540829885 0.08842503270598323 AGT(ph)PVSELTK ddPTM_A459_Selumetinib_30min_R1 3 AGTPVSELTK 10 0 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 AGT(1)PVSELTK;AGT(0.999)PVS(0.001)ELTK;AGT(1)PVSELTK 168.85 0.00059216 107351300.0 15701.699999999999 18408.6 16829.5 15557.800000000001 11797.1 13886.7 14256.400000000001 14304.6 10167.2 16107.6 True False 16067.519059810315 16253.312554074033 14544.146337826307 12840.922286075553 10730.054387947168 13747.012406114785 13181.028270106508 13925.195540110743 17252.995817092557 18175.167361310607 0.8840369246895171 0.8942593061713634 0.8002207654377017 0.7065091633439351 0.5903689454210025 0.7563623560010779 0.7252218374706635 0.7661660145013708 0.9492620053567665 1.0 14.149681028438263 -8.32197666987217 3.558180793123895 0.9954016741239103 0.7605009190142846 0.5104320221827575 0.08250082160208902 0.21424367072639833 5.106381993375612 0.0879760062374064 0.024050329412220166 4.764565811770806e-09 8.32197666987217 -0.23490075510962571 AGT(ph)PVSELTK ddPTM_A459_Selumetinib_30min_R2 4 AGTPVSELTK 10 0 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 AGT(1)PVSELTK;AGT(0.999)PVSELTK;AGT(1)PVSELTK;AGT(0.996)PVS(0.004)ELTK 164.9 0.00085996 114554000.0 1138970.0 969320.0 933170.0 847800.0 824530.0 723730.0 966370.0 837710.0 561890.0 790270.0 True False 1075670.6070581623 1043663.7271449529 873130.858158675 732328.177463427 720945.1700082747 823417.2381331808 1011308.1198258272 840147.5974096447 674283.7005183506 767452.8517319525 1.4016113232632312 1.3599059861327771 1.1376996726095072 0.9542321405292093 0.939399949301483 1.0729222469822484 1.3177462531327537 1.0947220998835798 0.8785995113532485 1.0 19.54971859604423 -5.319072957672488 3.122202494019062 1.049652355042376 1.3931591356868958 0.5874781888551308 0.11339723730669456 0.19359311989022127 3.707422081017963 0.033607890316847015 0.0885188601958515 4.796528643843361e-06 5.319072957672488 0.3435067806445198 AGT(ph)S(ph)T(ph)YIDTRT(ph)VFLSK ddPTM_A459_Selumetinib_30min_R2 1 AGTSTYIDTRTVFLSK 16 1 Q9Y6Q1 Q9Y6Q1 CAPN6 Calpain-6 4 AGT(0.995)S(0.996)T(0.664)Y(0.424)IDT(0.248)RT(0.674)VFLSK 90.725 0.017477 25034000.0 22521.0 25536.0 87186.0 130120.0 162230.0 102180.0 41195.0 87174.0 116810.0 101000.0 True False 21269.372978706062 27494.529088818486 81576.54768093926 112397.43153047976 141849.21704539855 116254.36750231213 43110.649126343895 87427.66190756731 140175.26394409666 98083.86757048478 0.21684884074765423 0.28031652676277713 0.8317019883246032 1.1459318878276186 1.4462033416806614 1.1852547251847476 0.4395284382048233 0.8913561839793915 1.4291367929936516 1.0 16.581728246983012 -5.344253309355463 2.8306117971073594 1.0635999900679272 0.21797405835375402 0.594384979676274 0.26989438689427786 0.20259409488047395 3.1138669943949737 0.08087547002030544 0.2168948018905036 4.526334970099851e-06 5.344253309355463 -0.8456259317141731 AGTAT(ph)SPAGSSPAVAGGTQR ddPTM_A459_Selumetinib_30min_R2 1 AGTATSPAGSSPAVAGGTQR 20 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AGT(0.005)AT(0.581)S(0.411)PAGSS(0.003)PAVAGGTQR 158.92 2.7805000000000003e-06 3629800.0 12245.0 8730.7 9547.2 16212.0 17050.0 13695.0 16193.0 19000.0 18028.0 9117.9 True False 11564.471920618793 9400.316616374826 8932.943546205406 14003.897632740101 14908.026571066051 15581.361939167784 16946.006585820767 19055.28685438067 21634.103744406904 8854.642535850744 1.306034870837131 1.0616257605335002 1.0088429329628652 1.5815316740389027 1.6836395722025277 1.7596827738761724 1.9137990627187542 2.1520108550096153 2.443249815767783 1.0 13.112218350852716 -6.189149296807973 1.2788161037465127 1.9432780955882252 1.1073288627211284 0.4124931868769224 0.36212231063792144 0.39222967400028974 1.3038415654609476 0.13763912198710881 0.2115370140930758 6.469201866689312e-07 6.189149296807973 -0.8359492328670968 AGTATS(ph)PAGSSPAVAGGTQR ddPTM_A459_Selumetinib_30min_R2 1 AGTATSPAGSSPAVAGGTQR 20 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 AGT(0.01)AT(0.04)S(0.649)PAGS(0.15)S(0.15)PAVAGGT(0.001)QR 56.817 0.040398 4969000.0 14180.0 10072.0 11839.0 17868.0 20924.0 16290.0 20006.0 22362.0 25539.0 11828.0 True False 13391.932367037518 10844.490013415567 11077.29162932858 15434.34757598076 18295.340057066634 18533.799634103194 20936.31864113693 22427.069717771607 30647.51361928159 11486.494907165314 1.1658850219559656 0.9441078502242436 0.9643752701634446 1.3436951568535291 1.5927696137882708 1.6135296088053588 1.8226899337305051 1.9524728734943786 2.668134523801823 1.0 13.487651007689458 -6.412890437958546 1.0276062730682913 1.9360606836385068 0.9952314726808253 0.4371299890656464 0.38813283608067906 0.44760748307368664 1.00722428146699 0.18071968687736997 0.23613602260727365 3.864644604358188e-07 6.412890437958546 -0.9408292109576815 AGTDS(ph)PVSCASVTEER ddPTM_A459_Selumetinib_30min_R1 4 AGTDSPVSCASVTEER 16 0 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 AGTDS(0.998)PVS(0.002)CASVTEER;AGTDS(1)PVSCASVTEER;AGT(0.039)DS(0.951)PVS(0.008)CAS(0.002)VTEER;AGT(0.001)DS(0.976)PVS(0.023)CASVTEER 340.47 1.544299999999999e-153 117391000.0 9017.1 11263.900000000001 10690.2 11359.1 10064.5 9016.1 10014.8 8496.900000000001 5081.07 8672.8 True False 9227.180885777692 9945.117351554958 9238.529557065316 9375.44642171521 9154.167752031792 8925.406219963814 9259.375573038267 8271.534610179036 8622.204683330172 9786.0383602259 0.9428923683030292 1.0162557089471072 0.9440520481315643 0.9580430892055882 0.9354314192388345 0.9120551025264712 0.9461822273936523 0.8452383186844667 0.8810720299619934 1.0 13.256509222654705 -6.34635909545459 1.0290888750114213 0.9054115251502817 0.9758814668183055 0.2109354920900014 0.04262168624464676 0.6684819428298634 1.4996941997378428 0.019454888936739367 0.027304435879052107 4.504441017868784e-07 6.34635909545459 0.07046994166802378 AGTDS(ph)PVSCASVTEER ddPTM_A459_Selumetinib_30min_R2 4 AGTDSPVSCASVTEER 16 0 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 AGT(0.226)DS(0.774)PVSCASVTEER;AGT(0.008)DS(0.992)PVSCASVTEER;AGT(0.002)DS(0.992)PVS(0.005)CASVTEER;AGT(0.007)DS(0.989)PVS(0.003)CASVTEER 254.72 5.7234e-30 123565000.0 128678.0 125042.0 143428.0 151352.0 145765.0 130128.0 119780.0 127271.0 122361.0 153371.0 True False 121526.59189884725 134632.31932659954 134199.99863259893 130737.59650323729 127452.6975443662 148051.95081562808 125350.00733956734 127641.3375391516 146836.61905199557 148942.7807242859 0.8159280450377123 0.9039197379819499 0.90101714215355 0.8777706167931095 0.8557158455386913 0.9940189789372412 0.8415984093355144 0.8569823721462119 0.9858592564067329 1.0 17.184398672104948 -14.522878745270672 0.11965693095072534 1.3712308856138242 0.8369383913492286 0.3629725342247828 0.05104647546797508 185.21417122704491 1.4327047843955305 16.434315890512202 0.4959760080641832 3.000000000066766e-15 14.522878745270672 -0.5342924942645956 AGTEDEEEEEEGRR ddPTM_A459_Selumetinib_30min_R1 3 AGTEDEEEEEEGRR 14 1 F8WBH7;O95456-2;O95456 F8WBH7 PSMG1 Proteasome assembly chaperone 1 0 ;; 171.62 0.00018631 13092000.0 4681.73 5533.15 4582.950000000001 4903.51 5009.889999999999 4529.68 5395.51 4732.3099999999995 2506.5 4788.549999999999 False True 4790.805199939225 4885.326225708353 3960.610562342377 4047.2040287826258 4556.74633406792 4484.1155318203755 4988.52233674998 4606.793766090732 4253.34743248313 5403.207036926911 0.8866595648098667 0.904153069153333 0.7330110682923201 0.7490373774543505 0.8433410570659128 0.8298988917461005 0.923252117243913 0.8526035990489934 0.7871894235061985 1.0 12.399600248031305 -7.085595621835835 7.961018160690615 0.8785182600429491 0.820346066602993 0.16517121861109263 0.07101795909475894 0.7019836008631358 58.956687611656825 0.028260805165891346 0.021903328633040633 8.211157417896073e-08 7.085595621835835 -0.058172193439956055 AGTEDEEEEEEGRR ddPTM_A459_Selumetinib_30min_R2 1 AGTEDEEEEEEGRR 14 1 F8WBH7;O95456-2;O95456 F8WBH7 PSMG1 Proteasome assembly chaperone 1 0 144.28 0.00071854 6869600.0 16370.0 15471.0 17917.0 20421.0 25615.0 15380.0 18271.0 19926.0 17349.0 18162.0 False True 15460.220934302139 16657.57595289439 16764.239726554624 17639.624571810116 22397.01469899455 17498.455394260724 19120.637703299657 19983.981361073114 20819.28477156178 17637.615869456917 0.8765482278744161 0.9444346716803338 0.950482188218266 1.0001138874079165 1.2698436605470862 0.9921100178036433 1.0840828967372451 1.133031896656702 1.1803910985279231 1.0 14.106367940117803 -6.020249484306478 11.003428164405793 1.1117279923623347 0.9340280602888269 0.5361449745230981 0.07836339845060086 0.514772632210895 278.1874345428309 0.022471114429982147 0.030045961186471366 9.544441396284784e-07 6.020249484306478 -0.17769993207350776 AGTFIAPPVYSNITPYQS(ph)HLRSPVR ddPTM_A459_Selumetinib_30min_R1 1 AGTFIAPPVYSNITPYQSHLRSPVR 25 1 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 AGTFIAPPVYS(0.005)NIT(0.005)PY(0.062)QS(0.464)HLRS(0.464)PVR 79.78399999999998 0.000115 27759000.0 1943.9 1866.9 2719.7 3179.4 2618.2 2108.1 2266.2 1875.4 1296.1 1287.3 True False 1989.189087829043 1648.3224801017357 2350.3796782427407 2624.1774747296267 2381.3842722807544 2086.8944280016535 2095.2587094719133 1825.6582998422666 2199.38703660139 1452.5374943638499 1.3694579971584306 1.1347882491829455 1.6181197988779683 1.8066159978052103 1.63946492363951 1.4367232764037015 1.4424816692181486 1.2568751628967954 1.5141688563190092 1.0 10.504359689073048 -9.404332664095962 0.5916511563314497 0.9756978541351014 1.4971217100431493 0.37221412075720206 0.1829948346493261 4.240232631915712 1.903822787032341 0.47149468191128113 0.08614621999570758 3.9415526844839356e-10 9.404332664095962 0.521423855908048 AGTGYAS(ph)PDRTHVLAAGK ddPTM_A459_Selumetinib_30min_R1 1 AGTGYASPDRTHVLAAGK 18 1 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 AGTGYAS(0.533)PDRT(0.467)HVLAAGK 116.61 0.0049235 21163000.0 3126.8 3227.1 4149.2 4098.4 3626.2 3375.6 3621.2 3211.2 1753.4 2456.8 True False 3199.6483563063166 2849.2696317619116 3585.761429924172 3382.6913764961646 3298.2108502576066 3341.644528799575 3348.0499685551545 3126.0285445523564 2975.391736730869 2772.1542112585316 1.1542100880649444 1.0278178682088435 1.2934927701212806 1.2202392503122887 1.189764565355926 1.2054324089288309 1.2077430450866482 1.1276531918233976 1.07331393204856 1.0 11.436791799579382 -8.323568887021235 1.6938278727447191 1.0038873891643594 1.1856920159958588 0.4756872510921817 0.0636784466708563 0.32149695995946653 1.8121255771604978 0.06297949585109647 0.01860328390837583 4.7471298683657955e-09 8.323568887021235 0.18180462683149945 AGTGYAS(ph)PDRTHVLAAGK ddPTM_A459_Selumetinib_30min_R2 1 AGTGYASPDRTHVLAAGK 18 1 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 AGT(0.157)GY(0.316)AS(0.375)PDRT(0.152)HVLAAGK 54.008 0.040037 8720900.0 52425.0 53357.0 55821.0 64095.0 57467.0 47678.0 49526.0 43018.0 35411.0 58695.0 True False 49511.428373902825 57449.310330203945 52229.53763330946 55365.15042995783 50247.48169850162 54245.21172220825 51829.05713390723 43143.17525798672 42494.18946600804 57000.32284207537 0.8686166306650365 1.0078769288618334 0.9163024879353086 0.9713129271802909 0.8815297737473677 0.9516649909597809 0.9092765540557444 0.7568935245773756 0.7455078734157716 1.0 15.798682470078445 -7.619992918027389 6.2404096736854076 0.8143260305025888 0.9345694517854729 0.24301695502216536 0.07555368446485611 0.2311147300888507 12.483527797910654 0.034003437143176794 0.019368717058969837 2.3988720367339757e-08 7.619992918027389 0.12024342128288412 AGTGYASPDRT(ph)HVLAAGK ddPTM_A459_Selumetinib_30min_R1 2 AGTGYASPDRTHVLAAGK 18 1 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 AGTGYASPDRT(1)HVLAAGK;AGT(0.004)GYAS(0.405)PDRT(0.591)HVLAAGK 188.1 2.1162e-09 28126400.0 2390.0 2455.5 2978.1 2721.3999999999996 2890.7 2517.1 2544.23 2211.7599999999998 1653.79 1868.3400000000001 True False 2445.682349869547 2168.0089184690187 2573.6903775323394 2246.1585770048478 2629.236695394536 2491.78025934394 2352.316682728675 2153.0969399910055 2806.3608419574234 2108.15963817273 1.1601030138255415 1.0283893492753535 1.2208232863063033 1.065459435013057 1.2471715366268254 1.1819694363865714 1.1158152542791167 1.0213158913606872 1.3311899114005745 1.0 11.04176840233928 -5.257912505796752 24.98129631373581 1.1493916349182902 1.0942461940764432 0.04223677099016876 0.10214832837340061 1013.8858159094998 7181419.6289388845 0.024685489507674244 0.05998417037357946 5.521886735784716e-06 5.257912505796752 -0.05514544084184703 AGTLSITEFADMLSGNAGGFRS(ph)R ddPTM_A459_Selumetinib_30min_R1 5 AGTLSITEFADMLSGNAGGFRSR 23 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 AGTLSITEFADMLS(0.004)GNAGGFRS(0.996)R;AGTLSITEFADMLS(0.017)GNAGGFRS(0.983)R;AGTLSITEFADMLS(0.267)GNAGGFRS(0.733)R;AGTLSITEFADMLS(0.003)GNAGGFRS(0.997)R;AGTLSITEFADMLS(0.01)GNAGGFRS(0.99)R 112.06 7.6088e-06 73406000.0 4152.46 2702.33 20778.0 25545.499999999996 10067.060000000001 7881.42 3534.83 3505.0699999999997 2826.42 1935.5899999999997 True False 4249.204238719372 2385.939947320866 17956.461725384284 21084.45797342445 9156.4962004838 7802.140070556799 3268.194927192041 3412.1041575280665 4796.228306450817 2184.0418307432005 1.9455690723988672 1.092442421997459 8.221665662545455 9.653870945434084 4.192454591113745 3.572340035218938 1.496397587806236 1.5622888305060405 2.196033170673624 1.0 11.092784772983881 -6.977076213987912 2.3892747184078553 1.6157050815781377 5.251953713554036 0.313481508112348 2.4096917810481844 0.41837261229742523 4.816168694445448 1.1351858542157145 0.9141292229070563 1.054201879121028e-07 6.977076213987912 3.636248631975898 AGTQIENIDEDFR ddPTM_A459_Selumetinib_30min_R2 2 AGTQIENIDEDFR 13 0 O43707;F5GXS2;O43707-3;K7EP19 O43707 ACTN4 Alpha-actinin-4 0 ; 141.34 0.011547 13885900.0 52755.0 37939.0 54193.0 51988.0 55025.0 39452.0 51358.0 59058.0 55710.0 46149.0 False True 49823.08829499751 40848.79930688771 50706.28138087702 44907.144715697774 48112.26757025862 44886.15489040146 53746.24876394638 59229.849002421804 66853.5566674567 44816.55846049812 1.111711608532195 0.9114666701347083 1.1314184560951992 1.0020212675473397 1.0735377553067886 1.0015529177673177 1.1992497998550915 1.3216063668661158 1.491715539165781 1.0 15.451744245653302 -7.460753359182136 3.353669893080705 1.3020800286438563 1.0373648175323724 0.4052255600899759 0.12744792612977865 0.21193899962717314 4.695285845209769 0.05744309580370742 0.034833840974067304 3.46135896564241e-08 7.460753359182136 -0.2647152111114839 AGTQIENIDEDFRDGLK ddPTM_A459_Selumetinib_30min_R1 2 AGTQIENIDEDFRDGLK 17 1 O43707;F5GXS2;O43707-3;K7EP19 O43707 ACTN4 Alpha-actinin-4 0 ; 261.64 7.2043000000000004e-40 33492000.0 6142.5 5035.8 6678.6 5869.799999999999 6025.8 4733.3 5715.700000000001 5965.4 3607.1000000000004 4953.6 False True 6285.608298775598 4446.206194920093 5771.682802923839 4844.749619792404 5480.767453941396 4685.687299492542 5284.560147263533 5807.178213649916 6120.985247839582 5589.442812150057 1.1245500687675436 0.7954650122289736 1.0326043215573542 0.8667679020279311 0.9805570319151619 0.8383102675828482 0.945453835895094 1.0389547596813329 1.0950975711808133 1.0 12.448488758747917 -7.765044939160692 4.684334193400485 1.0528115659822177 0.9325831517663636 0.2073189155038766 0.0926337955325879 0.2551663113965219 14.224536370705357 0.04598088726561794 0.02306203987493599 1.717730633651233e-08 7.765044939160692 -0.12022841421585406 AGTQIENIDEDFRDGLK ddPTM_A459_Selumetinib_30min_R2 2 AGTQIENIDEDFRDGLK 17 1 O43707;F5GXS2;O43707-3;K7EP19 O43707 ACTN4 Alpha-actinin-4 0 ; 200.0 1.597e-07 8945000.0 46779.0 45533.0 39765.0 49951.0 50599.0 34996.0 37822.0 42045.0 32107.0 39066.0 False True 44179.21045117404 49025.23468832911 37206.563192858404 43147.58762971876 44242.30125920067 39816.38133794203 39580.79794287122 42167.34398907555 38529.297144534794 37938.06307434223 1.1645088565697688 1.2922440081419235 0.9807185759575969 1.137316566351005 1.1661718515387793 1.0495101254884602 1.0433004411772404 1.1114785672227323 1.0155841922934759 1.0 15.211358403465585 -1.5228787453174348 0.19484072783440298 1.0049165493711276 1.9579893883649024 0.37059701082683594 0.07270598684486937 59.24255937986417 0.7039251290757162 0.14030158536161003 17.10157177896014 0.02999999999743741 1.5228787453174348 0.9530728389937748 AGTQIENIEEDFR ddPTM_A459_Selumetinib_30min_R2 2 AGTQIENIEEDFR 13 0 P12814-4;P12814-3;P12814;P12814-2;A0A494C1A0;P35609;P35609-2;G3V2N5;Q08043;A0A087WSZ2;A0A494C033;A0A494C166;G3V5M4;A0A494C0Q3;G3V380 P12814-4 ACTN1;ACTN2;ACTN3 Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 0 ; 148.62 0.0075015 2835000.0 12927.7 10095.8 10017.0 12118.2 13945.3 10708.9 11225.599999999999 11244.099999999999 11125.0 12708.400000000001 False True 12209.230187683432 10870.115396886511 9372.517125684972 10467.680254938992 12193.366741436215 12183.953769284697 11747.612643104407 11276.818469439042 13350.31085847166 12341.475471611395 0.9892844835099205 0.8807792408525711 0.7594324639095382 0.8481708916423633 0.9879991067100633 0.9872363962729547 0.9518807269136477 0.9137334101889729 1.0817434989180061 1.0 13.59122726417674 -6.26359143329477 24.632097830623053 0.9810315017780278 0.8623723497408045 0.4316463332707209 0.06573611331765336 158.30617604830115 1811949.0348840503 0.020775805779872744 0.024742097815763857 5.450151399688033e-07 6.26359143329477 -0.11865915203722333 AGTVS(ph)PGKEDPVSSR ddPTM_A459_Selumetinib_30min_R1 1 AGTVSPGKEDPVSSR 15 1 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 AGTVS(1)PGKEDPVSSR 125.33 0.006655299999999999 0.0 472.44 445.22 900.01 695.57 658.53 607.05 537.36 623.25 407.96 551.46 True False 483.44693279178614 393.0934354228375 777.793585401055 574.1017569659962 598.9660777729144 600.9436281572996 496.826502568982 606.7193853986846 692.2783237804975 622.2452626752806 0.7769395153178907 0.6317339142652079 1.24997911925759 0.9226293736616068 0.9625884095890426 0.9657664978815639 0.7984415991098537 0.9750486211661233 1.1125489663097101 1.0 9.281339531387792 -5.232342298734501 24.987733372426444 0.9851958317693986 0.7043366502457118 0.500128583318755 0.11699309569219692 599.3186206802144 514675.72193412087 0.029720544572578278 0.07860657554384051 5.856763688571733e-06 5.232342298734501 -0.28085918152368683 AGTVS(ph)PGKEDPVSSR ddPTM_A459_Selumetinib_30min_R2 1 AGTVSPGKEDPVSSR 15 1 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 AGT(0.009)VS(0.991)PGKEDPVSSR 107.09 0.020526 2129300.0 7910.2 6870.3 7467.3 6633.1 6655.9 3538.7 10112.0 7381.2 4462.6 6981.4 True False 7470.582751039504 7397.229918503669 6986.862047781508 5729.660337264271 5819.7263374990325 4026.1238038797433 10582.228036547867 7402.678069976561 5355.244695462074 6779.828842144392 1.101883679511389 1.0910644045350264 1.0305366419208355 0.8451039798597684 0.8583883860493314 0.5938385610640755 1.560839998019893 1.0918679869852244 0.7898790397440569 1.0 12.72703313741805 -9.666080113392646 15.778135053633289 0.9999884746694325 0.9988778821030281 0.0 0.24406566431254956 0.0 0.0 0.24283701116884818 0.05889662628579158 2.157346411274933e-10 9.666080113392646 -0.0011105925664044447 AGVDYAPNLPPFPS(ph)PADVK ddPTM_A459_Selumetinib_30min_R1 3 AGVDYAPNLPPFPSPADVK 19 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 AGVDYAPNLPPFPS(1)PADVK;AGVDYAPNLPPFPS(1)PADVK;AGVDYAPNLPPFPS(1)PADVK 147.1 4.2837e-05 20144000.0 11662.199999999999 13275.900000000001 10601.2 10756.6 11962.0 10577.7 14272.999999999998 13942.3 8416.8 12504.5 True False 11933.90656930904 11721.551456201532 9161.615268223313 8878.161736389484 10880.03921206263 10471.297941783163 13196.376118741768 13572.504913027 14282.694861250355 14109.57437914453 0.8458020241169456 0.8307515975483462 0.649319038408782 0.6292295924611563 0.7711103765216688 0.7421413049326895 0.9352781142886516 0.9619358138179295 1.0122697168216297 1.0 13.784386848678192 -7.349757827265909 2.5046747675269314 0.9901514566130734 0.7372655894018498 0.7543120809354046 0.06545811810146548 0.1631595503316036 1.9988254119981053 0.0359434603503445 0.022331293469368102 4.469327428015855e-08 7.349757827265909 -0.2528858672112235 AGVDYAPNLPPFPS(ph)PADVK ddPTM_A459_Selumetinib_30min_R2 1 AGVDYAPNLPPFPSPADVK 19 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 AGVDYAPNLPPFPS(1)PADVK 117.65 0.00045755 3112900.0 17595.0 17157.0 17098.0 18879.0 21218.0 19199.0 26429.0 24250.0 23427.0 19538.0 True False 16617.14033836567 18472.88673154992 15997.933294894845 16307.647631908478 18552.405148673293 21843.48797883041 27658.000868069983 24320.563485196373 28113.054605071047 18973.887174179563 0.8757899836665494 0.9735952660606402 0.8431552874766476 0.8594784759814841 0.9777862057660046 1.151239478674455 1.4576876427149896 1.2817912988484923 1.481670800874606 1.0 14.21172765304936 -6.856103328867058 2.512766605242742 1.328325627656192 0.8948960418580403 0.6824872626819518 0.1289051258585634 0.14767890798489153 1.899549478616713 0.04722674754410902 0.04126717185341914 1.3928253776187112e-07 6.856103328867058 -0.43342958579815183 AGVLAGHDNR ddPTM_A459_Selumetinib_30min_R1 2 AGVLAGHDNR 10 0 B3KVK2;E7EP32;P62879-2;P62873-2;Q9HAV0;P62879;P62873 B3KVK2 GNB1;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein subunit beta-4 0 ; 142.36 0.0016969 11599400.0 11608.7 11124.5 12858.5 12011.900000000001 11666.7 10306.400000000001 9911.8 11787.5 6838.4 9506.5 False True 11879.160123401927 9822.038368360261 11112.386326684662 9914.247156288864 10611.449044923178 10202.726973462479 9164.144945964035 11474.85720880384 11604.265343025198 10726.75187615159 1.1074331037536578 0.9156582049965427 1.0359507197505369 0.9242543568413157 0.989250909076702 0.9511478489724222 0.854326179235893 1.0697420189531452 1.081806074849606 1.0 13.388925665189193 AGVLAGHDNR ddPTM_A459_Selumetinib_30min_R2 3 AGVLAGHDNR 10 0 B3KVK2;E7EP32;P62879-2;P62873-2;Q9HAV0;P62879;P62873 B3KVK2 GNB1;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein subunit beta-4 0 ;; 131.12 0.0037432 12383600.0 113003.0 68953.0 77555.0 109612.0 75853.0 82645.0 118145.0 101934.0 87827.0 75356.0 False True 106722.74564685045 74241.47338116002 72565.19573549954 94682.656508753 66323.66800557615 94028.59857338612 123638.9765998763 102230.61106391782 105394.85409141467 73180.27648159867 1.458353955162852 1.0145011326901474 0.9915949928632232 1.2938275319656813 0.9063052395306729 1.284889906053167 1.689512291347595 1.3969694565122874 1.4402084708974339 1.0 16.15916724586703 -6.997635408374725 24.985938452542268 1.4251030317854934 1.1242433396736524 0.2184447651737932 0.2166031323829472 90.27301831542553 953873.9883141883 0.07284397851954322 0.06384899581985565 1.0054595225991405e-07 6.997635408374725 -0.30085969211184094 AGVLAHLEEER ddPTM_A459_Selumetinib_30min_R1 4 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35579-2;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 ;;; 185.96 2.6794e-05 43745400.0 17911.5 23915.999999999996 19468.600000000002 23557.800000000003 20961.2 18517.0 18419.500000000004 15947.6 9424.5 14168.800000000001 False True 18328.80310028803 21115.90360175323 16824.871053364925 19443.87246467436 19065.263161000425 18330.735792090807 17030.102285375473 15524.617842894593 15992.688161754353 15987.503495799363 1.14644560391207 1.320775542429206 1.0523763799511021 1.2161919132516932 1.1925103357137483 1.1465664915668112 1.0652133580361716 0.971047033514245 1.0003242949067284 1.0 13.964657054113554 -7.358358728058197 1.956561598019457 0.9880023333667689 1.187080561117706 0.6499704395290306 0.06314869093980345 0.20703743323734636 1.5457230944875167 0.03327195209737866 0.019475168763803657 4.381686201535023e-08 7.358358728058197 0.1990782277509371 AGVLAHLEEER ddPTM_A459_Selumetinib_30min_R2 4 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35579-2;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 ;;; 193.83 2.8629e-05 28158500.0 139426.0 152793.0 165868.0 156545.0 193663.0 130306.0 121715.0 135263.0 117197.0 152283.0 False True 131677.26108650013 164511.7317930707 155196.23346342365 135223.30094481207 169333.32257081327 148254.4686999048 127374.98867369698 135656.59293600483 140639.67475778004 147886.19411124923 0.8903959012390587 1.112421161297279 1.0494301675427211 0.9143740682317422 1.1450245480212315 1.0024902567198295 0.8613041226679858 0.9173039697942018 0.950999351920451 1.0 17.174127850626917 -7.019606146687907 24.258332323128844 0.9264228822451731 1.0279338767759865 0.22129572592696256 0.07966438628312404 708.5405804158065 876662.529084248 0.029147446239125498 0.022940480551858364 9.558590432559738e-08 7.019606146687907 0.10151099453081336 AGVLT(ph)PPDLGPHPPPPAPR ddPTM_A459_Selumetinib_30min_R1 2 AGVLTPPDLGPHPPPPAPR 19 0 I3L2J0 I3L2J0 CIC 1 AGVLT(1)PPDLGPHPPPPAPR;AGVLT(1)PPDLGPHPPPPAPR 170.98 4.3915e-09 19504100.0 6702.3 7380.9 7850.6 7981.599999999999 7417.900000000001 6909.5 7046.5 6275.700000000001 3793.5 5077.4 True False 6858.450549594416 6516.740796712678 6784.531640259022 6587.763393188023 6746.952254736612 6839.9967033240455 6514.976831830301 6109.248049653471 6437.292433722227 5729.133748064173 1.197118247049448 1.1374740202067426 1.1842159632861529 1.14987076282064 1.1776566146699492 1.1938971935565692 1.1371661263854518 1.0663476047696976 1.1236065898963057 1.0 12.484101302902886 -8.421774532911225 0.6527667284136983 1.0028349364377729 1.1743871108430854 0.7687099065347347 0.028386530604446777 0.35251281000390206 0.35144021848602264 0.028236504621271245 0.011963971905334833 3.786391069022152e-09 8.421774532911225 0.17155217440531256 AGVLT(ph)PPDLGPHPPPPAPR ddPTM_A459_Selumetinib_30min_R2 2 AGVLTPPDLGPHPPPPAPR 19 0 I3L2J0 I3L2J0 CIC 1 AGVLT(1)PPDLGPHPPPPAPR;AGVLT(1)PPDLGPHPPPPAPR 143.33 0.00010445 16545300.0 100222.0 86263.0 113857.0 109752.0 105599.0 81600.0 73400.0 80667.0 76418.0 95702.0 True False 94652.06246045377 92879.09472073753 106531.56457812828 94803.58826723967 92332.70955296207 92839.6593089516 76813.24543934072 80901.72761485924 91703.73529732025 92938.83459634215 1.0184339288474256 0.9993572129899834 1.146254577441421 1.020064310887872 0.9934782371006411 0.998932897234818 0.8264924535901584 0.8704835601418585 0.986710622051737 1.0 16.503993933881418 -6.838611323580421 2.09348111145223 0.9119442701101944 1.0447323285860184 0.4109460614724697 0.06295297164721643 0.28902957882350816 2.5982501994602796 0.026095894355668645 0.022787270819445444 1.4500690275434368e-07 6.838611323580421 0.13278805847582398 AGVNSDS(ph)PNNCSGK ddPTM_A459_Selumetinib_30min_R1 3 AGVNSDSPNNCSGK 14 0 Q9Y4C1;F8WE62 Q9Y4C1 KDM3A Lysine-specific demethylase 3A 1 AGVNS(0.008)DS(0.99)PNNCS(0.002)GK;AGVNSDS(0.999)PNNCSGK;AGVNS(0.163)DS(0.832)PNNCS(0.004)GK 189.04 7.493e-05 11046000.0 3607.7200000000003 4138.1900000000005 4900.099999999999 4891.09 4379.8 3937.96 4371.54 3778.8 2219.36 3223.02 True False 3691.772856598896 3653.688791007661 4234.693334322628 4036.9529486303527 3983.647863316492 3898.3476977815994 4041.7912182529553 3678.5739487277165 3766.091824358972 3636.726011873359 1.0151363739104395 1.0046642994492632 1.1644246282224717 1.1100514406227782 1.0953940028230023 1.0719387946889827 1.1113818321911302 1.0115070359212464 1.0355720535622572 1.0 11.828424523020564 -7.773571888915601 24.8984400726127 1.0176546277405365 1.0832864339535917 0.31579835667296063 0.044565539711140675 296.9829311197421 609461.7964251812 0.025883132017325963 0.012581484313307878 1.6843335953753224e-08 7.773571888915601 0.0656318062130552 AGVNSDS(ph)PNNCSGK ddPTM_A459_Selumetinib_30min_R2 4 AGVNSDSPNNCSGK 14 0 Q9Y4C1;F8WE62 Q9Y4C1 KDM3A Lysine-specific demethylase 3A 1 AGVNS(0.005)DS(0.994)PNNCS(0.001)GK;AGVNSDS(1)PNNCSGK;AGVNSDS(0.999)PNNCSGK;AGVNS(0.002)DS(0.998)PNNCSGK 244.0 5.900000000000001e-20 12150100.0 51979.7 52525.2 58979.8 68836.0 62624.0 50024.2 56680.0 51245.0 46153.5 58306.0 True False 49090.87636522572 56553.713944862546 55185.10388035082 59460.418051276705 54756.61325433669 56914.579475525185 59315.73230928931 51394.11446593353 55385.48963653674 56622.554282818804 0.8669844903150465 0.9987842240812307 0.9746134659470113 1.0501189641548723 0.9670459757226406 1.005157400551868 1.0475636971977387 0.907661533763203 0.9781524401018159 1.0 15.789089211238126 -4.759506423678466 24.94983369016789 0.991857948241997 0.8669843283285225 0.48476706477084386 0.03870207128904233 43.494906195149746 561262.9138172693 0.009643183696282457 0.06081009663132303 1.739776964691584e-05 4.759506423678466 -0.12487361991347457 AGVNTVTTLVENK ddPTM_A459_Selumetinib_30min_R2 1 AGVNTVTTLVENK 13 0 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 146.36 0.0088745 0.0 12770.0 10252.0 12068.0 11355.0 11525.0 8943.1 6519.7 8829.4 8619.8 10245.0 False True 12060.294522360315 11038.295434624348 11291.558018644926 9808.429411532432 10077.126465192741 10174.930847621139 6822.8789685404645 8855.092092214147 10344.00085733519 9949.200230293256 1.2121873359869886 1.109465603176326 1.13492117529854 0.9858510417418069 1.012857941536846 1.022688317865046 0.6857716007932185 0.8900305438875603 1.0396816445446386 1.0 13.280364843467742 -5.891726803789574 0.894653769144307 0.9071784975332394 1.191133680278341 0.4872299847814924 0.09808570946947795 0.6054352872077887 0.9414453405709816 0.04530590683465088 0.12064970344848162 1.2831374961250906e-06 5.891726803789574 0.28395518274510156 AGVRPSSS(ph)GSAWEACSEAPSK ddPTM_A459_Selumetinib_30min_R2 1 AGVRPSSSGSAWEACSEAPSK 21 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 AGVRPS(0.228)S(0.228)S(0.392)GS(0.152)AWEACSEAPSK 85.182 0.00061661 6025100.0 22222.0 21252.0 23684.0 26803.0 23253.0 17415.0 17871.0 22526.0 19941.0 21537.0 True False 20986.990201714223 22881.960064049603 22160.197225189466 23152.38516224604 20331.750255542458 19813.758172370006 18702.036910714698 22591.54693061994 23929.75719809288 20915.17085015382 1.003433840061597 1.094036488058682 1.0595274303019375 1.1069661026496356 0.9721053870995717 0.9473390542360445 0.8941852325618059 1.0801512018465673 1.144133957572567 1.0 14.352262162549945 -4.456598864128406 17.235942101451773 1.0309729634253466 0.6213445816025444 0.013273165864166825 0.07478065450493733 12165872.704895254 59558935.178394206 0.020339014477506107 181016352.63706502 3.494629477254118e-05 4.456598864128406 -0.40962838182280226 AGVVNGTGAPGQS(ph)PGAGR ddPTM_A459_Selumetinib_30min_R1 2 AGVVNGTGAPGQSPGAGR 18 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;Q13330-2 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 AGVVNGTGAPGQS(1)PGAGR;AGVVNGTGAPGQS(1)PGAGR 214.94 2.0651e-12 21922000.0 4392.2 5760.1 5211.4 5937.7 6170.0 4273.4 5722.5 5483.7 1935.01 3779.2 True False 4494.529714266538 5085.704814202158 4503.720504171129 4900.792159433262 5611.924589401979 4230.413475936753 5290.847217788816 5338.254462432035 3283.5706424612736 4264.297132525334 1.053990745622564 1.1926244011965421 1.0561460339664481 1.1492614156863392 1.3160256930967131 0.9920541051583535 1.240731368701682 1.2518486157344058 0.7700145042465016 1.0 12.058092252000664 -8.258881665573343 24.998917048193253 0.8850072457676749 1.1568296734286692 0.502012551305246 0.10819460851156501 166.91253364748727 1631435.3496935288 0.07756633579246018 0.02629312736588418 5.5095779822887145e-09 8.258881665573343 0.2718224276609943 AGVVNGTGAPGQS(ph)PGAGR ddPTM_A459_Selumetinib_30min_R2 2 AGVVNGTGAPGQSPGAGR 18 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;Q13330-2 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 AGVVNGT(0.001)GAPGQS(0.999)PGAGR;AGVVNGT(0.002)GAPGQS(0.998)PGAGR 117.27 0.0010226 12014000.0 19924.3 20347.9 21609.0 19260.2 19569.2 17022.2 20732.9 19521.6 16805.7 21764.3 True False 18816.987169292366 21908.518501189297 20218.700466100276 16636.927534301805 17110.742145132313 19366.853537853378 21697.020931461957 19578.404624025152 20167.30959049141 21135.90810855749 0.8902852469193769 1.0365543977889926 0.9566042945613557 0.7871404175705069 0.8095579360606951 0.9163009906355593 1.0265478454969854 0.926310074942948 0.9541728458937653 1.0 14.3674084789334 -7.019025728978043 24.057600904365795 0.9707322454668909 0.8973292527386607 0.2288899263726919 0.07000835568251357 895.7350426478779 1132633.6946738479 0.02974444169819098 0.023450715853671738 9.571373657718067e-08 7.019025728978043 -0.07340299272823014 AGWGS(ph)PCHLSGESVILLGPTVGTESK ddPTM_A459_Selumetinib_30min_R2 2 AGWGSPCHLSGESVILLGPTVGTESK 26 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2;A8MXE8;Q7Z5J4-4 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 AGWGS(0.969)PCHLS(0.03)GES(0.001)VILLGPTVGTESK;AGWGS(0.647)PCHLS(0.206)GES(0.146)VILLGPTVGTESK 64.726 0.0011606 9084700.0 14062.1 13147.5 27299.0 43388.0 56191.0 22749.1 20072.2 23888.0 28764.0 38226.0 True False 13280.58477704642 14155.87097412442 25542.612060903848 37478.479551525255 49131.7842260864 25882.582029231264 21005.597072309753 23957.510125128712 34517.60373331043 37122.316056924334 0.3577520528805806 0.3813304900593335 0.6880662300740109 1.0095943231035147 1.3235107462246276 0.697224332381154 0.5658482364111985 0.6453667946900629 0.9298343260797692 1.0 15.17999910239649 -5.385835438851182 3.2326283249632 0.8638504108308898 0.36310006852389726 0.49086742111384984 0.2057445394446122 0.24042185701130617 4.654762053896575 0.0629847362643208 0.15121755130674738 4.113055418516692e-06 5.385835438851182 -0.5007503423069926 AGYS(ph)TDESSSSSLHATR ddPTM_A459_Selumetinib_30min_R2 1 AGYSTDESSSSSLHATR 17 0 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 AGYS(0.583)T(0.417)DESSSSSLHATR 133.35 0.00042095 20826000.0 15775.0 17397.0 39896.0 51288.0 71274.0 33229.0 25056.0 28695.0 27687.0 49938.0 True False 14898.288652328407 18731.29395982829 37329.13479548041 44302.485923265114 62319.9229223555 37805.993127171 26221.153647522107 28778.497699287032 33225.17363941614 48496.160185493856 0.30720553122852756 0.38624282599246246 0.769733823310949 0.9135256431398222 1.2850486035180286 0.7795667323467705 0.540685150066074 0.5934180683421456 0.6851093676763802 1.0 15.56558290209355 -5.250759962225209 3.6871440366510932 0.8183439510288679 0.3252965858660704 0.4722111269791942 0.20185132874600623 0.221084778943041 6.677447274419655 0.06058109002876498 0.16645580656246686 5.613581571134878e-06 5.250759962225209 -0.4930473651627975 AGYST(ph)DESSSSSLHATR ddPTM_A459_Selumetinib_30min_R1 2 AGYSTDESSSSSLHATR 17 0 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 AGYS(0.003)T(0.975)DES(0.011)S(0.011)SSSLHATR;AGYS(0.318)T(0.682)DESSSSSLHATR 282.09 1.8010999999999994e-63 17494200.0 3501.67 4295.6 2872.5 3563.7 8457.0 3851.7 6598.0 4357.6 739.86 1617.22 True False 3583.2520979362744 3792.6691550297396 2482.430277513059 2941.3666939340674 7692.065843204616 3812.955395063786 6100.307547919727 4242.022292520347 1255.488382763602 1824.8059400567906 1.9636346086339231 2.0783958840640917 1.360380423485361 1.6118791754056476 4.215278827383271 2.0895128141379904 3.3429897470247583 2.324642965809465 0.6880119990866148 1.0 10.833527332652595 AGYST(ph)DESSSSSLHATR ddPTM_A459_Selumetinib_30min_R2 2 AGYSTDESSSSSLHATR 17 0 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 AGYS(0.001)T(0.999)DESSSSSLHATR;AGYS(0.003)T(0.997)DESSSSSLHATR 293.38 1.178599999999999e-75 8558900.0 12682.3 11082.8 26594.0 39720.0 50113.0 23458.0 13007.5 19012.0 22049.0 32258.0 True False 11977.468537269388 11932.815123181299 24882.97099335791 34310.06747917819 43817.35692409579 26689.12656947777 13612.37452387227 19067.32177239397 26459.416100534057 31326.627723650523 0.3823414586124383 0.38091604460101 0.7943073609092027 1.0952365438708003 1.3987256244314863 0.8519629627841621 0.43453047815917306 0.6086618049219131 0.844630208330982 1.0 14.935101853113464 -5.302655292534912 4.276475238925378 0.8786056046951016 0.3744389260817093 0.39796853362845463 0.2461294296980154 0.23389588450857265 9.64215468285861 0.07564545301870267 0.17875663281283874 4.981323048230732e-06 5.302655292534912 -0.5041666786133923 AHAS(ph)PFSGALTPSAPPGPEMNR ddPTM_A459_Selumetinib_30min_R1 1 AHASPFSGALTPSAPPGPEMNR 22 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3 O15027 SEC16A Protein transport protein Sec16A 1 AHAS(0.984)PFS(0.016)GALTPSAPPGPEMNR 127.49 3.0236e-05 0.0 453.42 429.77 624.09 594.04 416.84 425.27 626.19 595.31 141.29 391.21 True False 463.98380379826347 379.4523286053476 539.3420058809834 490.302065511854 379.1368955990791 420.9921699142657 578.955984151539 579.5204449605948 239.75881058669117 441.42561420809545 1.0511030372141787 0.8596065030935595 1.221818554522594 1.110724094231463 0.8588919251530963 0.9537103338905994 1.3115595595651355 1.312838281938481 0.5431465752543867 1.0 8.786026535791983 -5.227541071425241 24.76240605640741 1.0530641208015499 0.9553548687626924 0.019136545136136274 0.222451447536224 2589.172487388251 1891358.3480611346 0.05637988486145676 0.14914316968635502 5.9218708082830225e-06 5.227541071425241 -0.0977092520388575 AHAS(ph)PFSGALTPSAPPGPEMNR ddPTM_A459_Selumetinib_30min_R2 4 AHASPFSGALTPSAPPGPEMNR 22 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3 O15027 SEC16A Protein transport protein Sec16A 1 AHAS(1)PFSGALTPSAPPGPEMNR;AHAS(0.994)PFS(0.006)GALTPSAPPGPEMNR;AHAS(0.791)PFS(0.209)GALTPSAPPGPEMNR;AHAS(0.874)PFS(0.12)GALT(0.002)PS(0.004)APPGPEMNR 132.39 1.4317e-05 15372100.0 45091.2 43919.3 45652.5 53691.2 62534.1 33359.9 41270.899999999994 45519.0 37471.3 41665.3 True False 42585.21161837533 47287.769087192435 42715.26785268372 46378.36593751388 54678.00729605289 37954.9234139791 43190.07862673688 45651.45275392386 44966.60703559991 40462.3145295498 1.0524660319981243 1.1686867060622044 1.0556802879254121 1.1462113939044085 1.3513316757033587 0.9380314461808766 1.0674149298897615 1.1282462035280856 1.1113206834166791 1.0 15.304291226998739 AHAWPS(ph)PYKDYEVK ddPTM_A459_Selumetinib_30min_R2 2 AHAWPSPYKDYEVK 14 1 Q8NFJ5 Q8NFJ5 GPRC5A Retinoic acid-induced protein 3 1 AHAWPS(0.551)PY(0.449)KDYEVK;AHAWPS(0.982)PY(0.017)KDY(0.001)EVK 85.473 0.013504 26691000.0 261800.0 86774.0 145422.0 168519.0 95631.0 104210.0 315540.0 174746.0 116677.0 117945.0 True False 247250.2040684359 93429.28677761358 136065.70684350168 145566.4214885102 83616.97882801286 118563.98157580699 330213.23523064866 175254.4819292422 140015.66022776614 114539.6213920878 2.158643455106754 0.8156940423068966 1.187935713334747 1.270882684256591 0.7300266738422183 1.0351350924231113 2.882960771279965 1.5300773636165386 1.2224211895067272 1.0 16.805487214227227 AHEAQDAGYR ddPTM_A459_Selumetinib_30min_R1 1 AHEAQDAGYR 10 0 E5RJH4;H0YC26;G3V111;E7ETC2;Q5F2F8;H0YB04;P16298-2;P16298;Q08209;P48454-3;P16298-3;P48454-2;P48454;Q08209-2;Q08209-3;Q08209-5;P16298-4 E5RJH4 PPP3CC;PPP3CA;PPP3CB Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform 0 99.815 0.025418 487150.0 141.7 0.0 140.31 0.0 144.97 154.53 118.08 191.34 0.0 0.0 False True 145.00133429979695 0.0 121.25667266766142 0.0 131.85748909653233 152.97556850201389 109.17313053324662 186.2650416400871 0.0 0.0 0.0 AHEAQDAGYR ddPTM_A459_Selumetinib_30min_R2 1 AHEAQDAGYR 10 0 E5RJH4;H0YC26;G3V111;E7ETC2;Q5F2F8;H0YB04;P16298-2;P16298;Q08209;P48454-3;P16298-3;P48454-2;P48454;Q08209-2;Q08209-3;Q08209-5;P16298-4 E5RJH4 PPP3CC;PPP3CA;PPP3CB Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform 0 136.63 0.0025769 1296600.0 3605.1 3794.2 3219.3 3685.5 3217.5 2141.3 4478.4 5140.0 3357.9 3973.9 False True 3404.742974358743 4085.202939724121 3012.1737429088166 3183.5285421578837 2813.288885185047 2436.2446382139474 4686.654473781246 5154.956549027193 4029.573827565122 3859.1631815678243 0.8822490302095833 1.058572220847232 0.7805251038089274 0.8249271648742624 0.7289893567138873 0.6312883191490748 1.2144224675871949 1.3357705560750452 1.0441574087385614 1.0 11.914072333014252 -7.277822274846342 24.799571737557304 1.1765685257859217 0.8233030640042804 0.5877555998604387 0.13487435921658714 531.2596071982667 804189.6261890819 0.05912909001070011 0.039999053079631454 5.2744566242275465e-08 7.277822274846342 -0.3532654617816413 AHFNAMFQPS(ph)SPTR ddPTM_A459_Selumetinib_30min_R2 1 AHFNAMFQPSSPTR 14 0 Q8WUA4;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 AHFNAMFQPS(0.868)S(0.131)PT(0.001)R 144.17 0.00099512 22801000.0 28605.0 26575.0 26204.0 28843.0 33887.0 27096.0 25201.0 29976.0 26281.0 28407.0 True False 27015.248614887758 28613.217047906932 24518.063168757995 24914.53364304974 29629.812106376274 30828.228047001867 26372.896434834165 30063.225197206055 31537.93435249381 27586.816099750155 0.9792811362211686 1.0372062127229706 0.8887601628293759 0.9031319001425244 1.074056969794518 1.1174985882941768 0.9559963839057534 1.0897678473841108 1.1432248737388524 1.0 14.75169133888066 -6.275243466410121 24.710942296233384 1.0652448473730396 0.953650329959288 0.42573577360101467 0.06331181442077674 694.7324314840106 1243649.8800084118 0.020400450124231608 0.02325418135983308 5.305869126887793e-07 6.275243466410121 -0.11159451741375159 AHFNAMFQPSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 AHFNAMFQPSSPTR 14 0 Q8WUA4;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 AHFNAMFQPS(0.002)S(0.989)PT(0.008)R;AHFNAMFQPS(0.025)S(0.974)PT(0.001)R 227.91 3.634e-13 159140000.0 4699.5 5928.200000000001 4492.5 4604.9 4822.3 4363.7 5302.2 4541.6 2227.31 4289.7 True False 4808.989206364825 5234.123588054592 3882.4431755360897 3800.7406596787 4386.123816446214 4319.805139922592 4902.250785174292 4421.142014804117 3779.5823937139453 4840.324780216427 0.9935261422994428 1.0813579306594705 0.8021038570396288 0.7852243046196492 0.9061631224361965 0.892461835945116 1.0127937706186518 0.9133978019149437 0.7808530553904169 1.0 12.240888138584971 -5.252245271959981 24.974532479765806 0.8853226450019492 1.037442045019228 0.36833126800482385 0.07898699500770813 708.8907479511022 1925594.325870973 0.02088913520217511 0.05363884276767979 5.594415622905461e-06 5.252245271959981 0.15211940001727886 AHFNAMFQPSS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 4 AHFNAMFQPSSPTR 14 0 Q8WUA4;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 AHFNAMFQPS(0.092)S(0.898)PT(0.01)R;AHFNAMFQPS(0.232)S(0.69)PT(0.078)R;AHFNAMFQPS(0.328)S(0.601)PT(0.07)R;AHFNAMFQPS(0.113)S(0.444)PT(0.444)R 191.63 0.00010737 220107000.0 157582.0 140858.0 182917.0 179359.0 183112.0 148616.0 147949.0 159020.0 137494.0 168035.0 True False 148824.22329072675 151661.35567014388 171148.31936497107 154929.9947884671 160107.83351795017 169086.50499827391 154828.9216553819 159482.72187282177 164996.64190334422 163183.39294263814 0.9120059376571555 0.9293920964338298 1.048809663034355 0.9494225606825552 0.9811527425111876 1.0361747108525365 0.9488031769863189 0.9773220117373266 1.0111117248392028 1.0 17.316134717172694 -5.075953961461025 8.823988080505138 0.9910952777969282 0.9162656079487067 0.47287074293405107 0.031106254418133583 0.27780812295827156 30.294602796631832 0.007675242454235119 0.020510810745349377 8.395489804197494e-06 5.075953961461025 -0.07482966984822148 AHGLSLIPSTGLCS(ph)PDLVNR ddPTM_A459_Selumetinib_30min_R1 2 AHGLSLIPSTGLCSPDLVNR 20 0 O75030-11;O75030-10;O75030-9;O75030-12;O75030-4;O75030-3;O75030-8;O75030-7;O75030-6;O75030-2;O75030-5;O75030 O75030-11 MITF Microphthalmia-associated transcription factor 1 AHGLSLIPS(0.002)T(0.006)GLCS(0.991)PDLVNR;AHGLSLIPSTGLCS(1)PDLVNR 140.4 4.4951e-05 21392000.0 2162.31 2630.1000000000004 3088.7 3188.6 3072.4 2551.7 2545.4 2124.89 1153.85 1790.31 True False 2212.6876158771624 2322.1666692996823 2669.2715050146508 2631.7708674350183 2794.5019624762785 2526.0322147582265 2353.3984286867017 2068.5310145845324 1957.9991761303258 2020.1137275961646 1.0953282410046048 1.1495227410106983 1.3213471442476419 1.3027835173253812 1.3833389300322203 1.2504405966113996 1.1649831376014306 1.023967604559562 0.9692519531859466 1.0 10.980220800223522 -7.661859525185498 2.2995243970182475 0.9850785547629854 1.2568482313297948 0.6790393249528313 0.07786798416843822 0.19737979811176826 2.0878119896446368 0.054471762793990394 0.025581173406301245 2.178414277865045e-08 7.661859525185498 0.2717696765668094 AHGS(ph)FSHVR ddPTM_A459_Selumetinib_30min_R1 1 AHGSFSHVR 9 0 Q8N3D4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 AHGS(1)FSHVR 94.767 0.015197 4268000.0 812.15 1027.4 1247.8 1313.3 1461.0 1078.4 1158.0 819.15 500.26 828.61 True False 831.0715148311933 907.1115303746988 1078.3556136747775 1083.956808694226 1328.8528079604996 1067.5522751088586 1070.6511276888507 797.4234810258041 848.9046824552213 934.9701648448919 0.8888749032639615 0.9702037182386298 1.1533583147582818 1.1593490888279312 1.4212783016246848 1.1418035732572938 1.145117959851123 0.8528865529715526 0.9079484184354176 1.0 9.868776518713963 -7.754120656131755 24.96289523119244 0.9103131046797586 1.1340750494220697 0.3255212645269707 0.1349081528693604 192.67364332856684 657182.6077967084 0.07181348941257078 0.0403780684396581 1.7614866004385268e-08 7.754120656131755 0.22376194474231115 AHGS(ph)FSHVR ddPTM_A459_Selumetinib_30min_R2 3 AHGSFSHVR 9 0 Q8N3D4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 AHGS(1)FSHVR;AHGS(0.987)FS(0.013)HVR;AHGS(0.977)FS(0.023)HVR 90.913 0.018465 14826300.0 17114.300000000003 12687.1 13236.9 13570.900000000001 14599.899999999998 10345.0 8448.6 10351.2 9097.699999999999 12687.099999999999 True False 16163.15571997111 13660.159774543748 12385.252265247007 11722.52000889172 12765.73003723797 11769.929847440004 8841.476640583298 10381.320278266587 10917.494210976853 12320.790457955445 1.311860288114443 1.1087080671616716 1.0052319538678576 0.9514422024215642 1.0361129085670986 0.9552901567155738 0.7176062827100854 0.8425855722238538 0.8861033915179936 1.0 13.588807196717807 -1.522878745310287 0.45507643087915206 0.868235716030372 11.299096038135128 0.7177634700977416 0.08036532046680196 48.54077010043666 0.5780216398469197 0.052546161667620356 471.9769765492587 0.029999999997931168 1.522878745310287 10.430860322104756 AHIAQLCEK ddPTM_A459_Selumetinib_30min_R2 2 AHIAQLCEK 9 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 ; 96.331 0.030319 10702000.0 197789.0 170015.0 209468.0 225418.0 213185.0 167924.0 164908.0 182248.0 157126.0 179678.0 False True 186796.67919210027 183054.6038156123 195991.05693151383 194715.67953226084 186402.79440191906 191054.00673770095 172576.5487590028 182778.31150721957 188555.59046725588 174490.22928049098 1.0705280173128022 1.0490822584762278 1.1232208115014883 1.1159116492377215 1.068270671490028 1.0949266759835812 0.9890327353607177 1.0474988328051629 1.0806083025093343 1.0 17.41278672827439 -7.232495229653715 24.726619679735 1.0332431947509046 1.0873775352915487 0.4477670067129108 0.03126945074621505 636.8822422456776 544081.1118099819 0.012348180193525056 0.009563088387335316 5.854701671646581e-08 7.232495229653715 0.05413434054064403 AHLDHIPDYTPPLLT(ph)TISPEQESDER ddPTM_A459_Selumetinib_30min_R2 1 AHLDHIPDYTPPLLTTISPEQESDER 26 0 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;K7EM61 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 AHLDHIPDYTPPLLT(0.759)T(0.144)IS(0.061)PEQES(0.036)DER 112.01 2.1305e-08 3206500.0 6840.3 7056.3 8182.5 9698.3 10371.0 6938.3 7489.1 7459.0 7381.8 6272.7 True False 6460.143509890462 7597.495520419405 7656.046858432392 8377.374809499333 9068.102262083645 7893.987845383566 7837.357989370122 7480.704455096076 8858.366264725035 6091.590852568126 1.0605018731957285 1.2472104092835472 1.25682223966252 1.3752359625347381 1.488626285243807 1.295882805729734 1.2865864072381035 1.2280379027659614 1.454195870852107 1.0 12.57260332977132 -4.619491654554401 1.5655927129293188 1.3167604695360713 0.8820504171637339 0.22918537668151417 0.12812922674632504 2.2013992823031874 3.7924585916636806 0.03435463615009595 1.6583489794004436 2.4016424176398597e-05 4.619491654554401 -0.4347100523723374 AHLDHIPDYTPPLLTT(ph)ISPEQESDER ddPTM_A459_Selumetinib_30min_R1 1 AHLDHIPDYTPPLLTTISPEQESDER 26 0 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;K7EM61 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 AHLDHIPDYTPPLLT(0.047)T(0.523)IS(0.219)PEQES(0.212)DER 112.01 2.1305e-08 6387000.0 1173.4 1642.6 1598.9 1757.6 1442.7 960.18 1429.7 1411.7 801.69 1227.6 True False 1200.7379369610571 1450.283628375977 1381.7781621290271 1450.6681542381568 1312.2080397293723 950.5214609736861 1321.8565779419262 1374.257130152142 1360.4093768790751 1385.1744178366046 0.866849633879606 1.0470043408981387 0.9975481385854051 1.0472819419404538 0.9473233282627377 0.6862106668546702 0.9542889046467018 0.9921184743640347 0.9821213555212722 1.0 10.43585193306999 -4.488960258325972 14.51383296490568 0.9558940239589915 0.5902260347146202 0.07562099855026705 0.0975389544766016 1033169.7421916556 14790188.245215964 0.026251196568838796 9231714.054720623 3.243692985672001e-05 4.488960258325972 -0.36566798924437127 AHLDHIPDYTPPLLTTIS(ph)PEQESDER ddPTM_A459_Selumetinib_30min_R1 1 AHLDHIPDYTPPLLTTISPEQESDER 26 0 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;K7EM61 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 AHLDHIPDYTPPLLT(0.07)T(0.059)IS(0.813)PEQES(0.059)DER 143.35 4.5443e-10 5110400.0 1473.1 2008.6 2377.4 2345.3 1951.3 1519.3 2083.0 1649.3 1028.5 1346.7 True False 1507.4203638463714 1773.432178227193 2054.562138123428 1935.7373817334715 1774.805259529996 1504.0172214140284 1925.8776329670786 1605.555206318573 1745.2893813320966 1519.5620629688465 0.9920097379249169 1.1670679476969485 1.3520751723093984 1.2738784607135571 1.1679715510023116 0.9897701831773509 1.2673899144365268 1.0565907411387445 1.148547613726441 1.0 10.569439884240207 -6.531406754582693 24.981448646768467 1.1038120896597567 1.2072554535419362 0.15549091306972795 0.11319384425317927 380.5975434609097 1114891.490497192 0.03814169808200755 0.038202178624822565 2.941665217673627e-07 6.531406754582693 0.10344336388217945 AHLDHIPDYTPPLLTTIS(ph)PEQESDER ddPTM_A459_Selumetinib_30min_R2 3 AHLDHIPDYTPPLLTTISPEQESDER 26 0 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;K7EM61 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 AHLDHIPDYTPPLLT(0.159)T(0.136)IS(0.65)PEQES(0.054)DER;AHLDHIPDYTPPLLTT(0.003)IS(0.673)PEQES(0.324)DER;AHLDHIPDYTPPLLT(0.021)T(0.267)IS(0.608)PEQES(0.104)DER 110.47 1.0605e-08 9162400.0 24965.1 23653.199999999997 28383.4 32311.0 28046.9 23510.3 19376.2 20757.6 18624.5 26690.699999999997 True False 23577.63968521358 25467.324382974693 26557.2429455093 27910.186060416057 24523.397679532693 26748.630419745627 20277.231693211914 20818.001179394327 22349.920412009473 25920.0701402331 0.909628699214683 0.9825330041620661 1.0245822176340171 1.0767789558213388 0.946116177419887 1.0319659736655742 0.7822984885267583 0.8031614523712516 0.8622631146864821 1.0 14.661782001739176 -7.2547838138735905 24.99585225029702 0.8455275502475017 0.9974920683965685 0.4603292375559578 0.06980443389993998 417.0338617648967 1566229.1927534472 0.0265862461439843 0.020103436801905555 5.561810480419261e-08 7.2547838138735905 0.15196451814906675 AHLGS(ph)SDNVATMSNEER ddPTM_A459_Selumetinib_30min_R1 2 AHLGSSDNVATMSNEER 17 0 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 AHLGS(0.749)S(0.251)DNVATMSNEER;AHLGS(0.956)S(0.044)DNVATMSNEER 122.3 0.00092226 5549100.0 2799.2700000000004 3895.44 3829.24 3889.4300000000003 4144.88 3308.29 4126.1 3224.9900000000002 1859.59 2891.8700000000003 True False 2864.4875445687553 3439.3600738590744 3309.2502405096975 3210.2140641434403 3769.9763358380005 3275.0116062869843 3814.864955057831 3139.452788956122 3155.5884109201293 3263.0696836992065 0.8778505585946926 1.0540259348553092 1.0141524886952884 0.9838018722616289 1.1553465605319635 1.003659720369269 1.1691031221659591 0.9621163791381416 0.9670613001873652 1.0 11.672014081547525 -4.75793884446714 24.91344535607782 1.0379994520862459 0.8778503233954459 0.3129705354598228 0.06937943651624288 116.81693636343093 831256.2553452202 0.017027271282666994 0.1214004461172861 1.746068009605453e-05 4.75793884446714 -0.1601491286908 AHLGS(ph)SDNVATMSNEER ddPTM_A459_Selumetinib_30min_R2 1 AHLGSSDNVATMSNEER 17 0 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 AHLGS(0.968)S(0.032)DNVATMSNEER 114.54 0.0017023 8776000.0 15536.0 13138.0 14921.0 18317.0 19769.0 10366.0 10321.0 10720.0 10155.0 16187.0 True False 14672.571315535602 14145.642354671736 13960.99910475645 15822.193001412552 17285.441482897655 11793.822406820978 10800.946950673519 10751.19342520847 12186.283754407164 15719.639251123177 0.9333910963947368 0.8998706731556211 0.888124649791752 1.0065239251773572 1.0996080257797647 0.7502603729267071 0.6870989071776431 0.6839338520087407 0.7752266804428383 1.0 13.940280489220559 -6.78935664926241 24.73389326057621 0.7537868587332054 0.9598374540519727 0.4504588296956603 0.10078360600763488 162.0380292601154 143559.73960854838 0.0354383413599738 0.031260458293741335 1.624214378262499e-07 6.78935664926241 0.20605059531876735 AHLGSS(ph)DNVATMSNEER ddPTM_A459_Selumetinib_30min_R2 1 AHLGSSDNVATMSNEER 17 0 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 AHLGS(0.308)S(0.692)DNVATMSNEER 168.68 1.1317e-06 4269000.0 8912.6 3906.3 7155.7 8202.8 7339.2 6241.1 6979.9 5688.8 4505.6 8144.8 True False 8417.27337196464 4205.900649265811 6695.31005253708 7085.564489380733 6417.184082719535 7100.754873935018 7304.479180409466 5705.353466168463 5406.84589698246 7909.638461268178 1.0641792811621218 0.5317437288519842 0.8464748528422119 0.8958139520633263 0.8113119346912155 0.8977344424408156 0.9234909049481783 0.7213165929272708 0.683576869342213 1.0 12.949396037254479 -4.466918728705849 22.38080808298003 0.8125427432507087 5.564975015619844 0.2551235992675561 0.12907239684921323 441.30267974353967 188116.27183651595 0.03067401715489121 6738.782712026814 3.412567664147893e-05 4.466918728705849 4.752432272369135 AHLGTALK ddPTM_A459_Selumetinib_30min_R2 2 AHLGTALK 8 0 D6RD47;P62266;D6RDJ2;D6RIX0;D6R9I7 D6RD47 RPS23 40S ribosomal protein S23 0 ; 141.52 0.0031937 4008700.0 185685.0 142599.0 162152.0 186355.0 187936.0 142160.0 155236.0 166133.0 139182.0 167948.0 False True 175365.37105594925 153535.88477194676 151719.31685774843 160973.12751969375 164325.79951084265 161741.24960000694 162454.78159429823 166616.41952520143 167022.28907000448 163098.90485869098 1.075208758807338 0.9413667424987947 0.9302289122615395 0.9869663297810675 1.0075223966293008 0.9916758775305063 0.9960507198687151 1.021566758339414 1.0240552455867973 1.0 17.315387569421986 -6.964193076112631 1.0882765035059665 1.0145815829991935 0.9793223636018459 0.07447690591939649 0.03757265999256629 1.149164554203539 2.820425806861863 0.02314515892281766 0.017177661633045578 1.0859427341857053e-07 6.964193076112631 -0.03525921939734766 AHLPLGQSNS(ph)CGSVLPPSLAAMAK ddPTM_A459_Selumetinib_30min_R1 2 AHLPLGQSNSCGSVLPPSLAAMAK 24 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PRT1;A0A1W2PRJ2 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 AHLPLGQS(0.021)NS(0.952)CGS(0.027)VLPPSLAAMAK;AHLPLGQS(0.093)NS(0.853)CGS(0.054)VLPPSLAAMAK 128.58 8.3979e-08 64064000.0 7847.7 7935.4 8999.5 8885.900000000001 8793.9 7052.6 8405.7 8489.599999999999 3560.5 6840.1 True False 8030.536141033994 7006.319678932625 7777.417330714982 7334.144374001382 7998.493297689142 6981.657247248451 7771.6512815321075 8264.428229892768 6041.908451368915 7718.093463216168 1.0404818468844546 0.9077785482028947 1.0076863370185327 0.950253376556703 1.0363301942130319 0.9045831435603217 1.0069392549560576 1.0707862335796254 0.7828239551858474 1.0 12.914028799142711 -8.25242583054809 24.9998177878032 0.8914119696331705 0.9862695853300371 0.23348966265634807 0.07154538685083929 822.4343002484017 2281105.150964699 0.046255015412255636 0.016895748724732863 5.592090219572174e-09 8.25242583054809 0.09485761569686657 AHLPLGQSNS(ph)CGSVLPPSLAAMAK ddPTM_A459_Selumetinib_30min_R2 1 AHLPLGQSNSCGSVLPPSLAAMAK 24 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PRT1;A0A1W2PRJ2 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 AHLPLGQS(0.302)NS(0.393)CGS(0.302)VLPPS(0.002)LAAMAK 52.451 0.0174 16618000.0 23889.0 12809.0 17923.0 21148.0 20177.0 15555.0 14874.0 19772.0 13203.0 17655.0 True False 22561.345015243973 13791.409112573469 16769.85369308692 18267.60591766516 17642.18487533136 17697.56005576889 15565.670472271868 19829.533246569197 15843.968922642798 17145.254276801108 1.3158944539989277 0.804386385288805 0.9781046942988687 1.0654613587377753 1.0289835653941066 1.0322133326255238 0.9078704941304637 1.1565610475313937 0.9241023006629273 1.0 14.065521680216095 -4.737432918919731 24.936483848028562 0.9956951405928627 1.3158958978161075 0.5363042746543638 0.09107831588248422 1702.194547297605 1768044.751757311 0.022082147883986415 1.3911659961937777 1.8304888215884133e-05 4.737432918919731 0.3202007572232448 AHLPLGQSNSCGSVLPPS(ph)LAAMAK ddPTM_A459_Selumetinib_30min_R2 1 AHLPLGQSNSCGSVLPPSLAAMAK 24 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PRT1;A0A1W2PRJ2 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 AHLPLGQS(0.084)NS(0.304)CGS(0.105)VLPPS(0.507)LAAMAK 45.992 0.044173 14081000.0 15332.0 11501.0 14042.0 12343.0 14745.0 8483.6 9316.7 11173.0 8247.3 11223.0 True False 14479.908818858905 12383.089718456364 13138.55300777362 10661.862107137373 12892.601278027501 9652.138893546833 9749.945010690819 11205.511580210281 9896.990448815568 10898.962829144091 1.3285584184340253 1.1361713873675834 1.205486541585481 0.9782455701773103 1.1829200154304933 0.8856015975884218 0.8945754897538717 1.028126414950831 0.9080671807000548 1.0 13.411903230841116 -5.057235452441545 0.5264602847837898 0.9428612427288007 1.4640961770743925 0.6389473048420657 0.086261221517878 2.102920671686203 0.5493397313394464 0.05276127996676095 0.6516905918167301 8.765254846414435e-06 5.057235452441545 0.5212349343455919 AHLS(ph)ENELEALEK ddPTM_A459_Selumetinib_30min_R1 2 AHLSENELEALEK 13 0 P98175-5;P98175-2;P98175;P98175-4;P98175-3 P98175-5 RBM10 RNA-binding protein 10 1 AHLS(1)ENELEALEK;AHLS(1)ENELEALEK 222.57 7.419399999999999e-09 11643300.0 2405.12 2620.3999999999996 2198.17 1885.8600000000001 2354.7400000000002 2214.01 2159.0 2107.48 1328.66 2539.2 True False 2461.1546164511487 2313.6023498090904 1899.6705876835103 1556.5299529765427 2141.7541827631144 2191.7390695602385 1996.144891779127 2051.5827843401844 2254.6389785130805 2865.1310539024976 0.8590024575311812 0.807503149518348 0.663030958076432 0.5432665814209253 0.7475239849311269 0.7649699187668729 0.6967028223927998 0.7160519870620903 0.7869235075450086 1.0 11.484385415438688 -8.731189378704501 2.3432551011152194 0.9999188125514716 0.7206303213870207 0.5118647099465939 0.0805302570121199 0.7731739540071462 7.079982313306556 0.08406434935322753 0.02284663284540138 1.8569945164039287e-09 8.731189378704501 -0.279288491164451 AHLS(ph)ENELEALEK ddPTM_A459_Selumetinib_30min_R2 4 AHLSENELEALEK 13 0 P98175-5;P98175-2;P98175;P98175-4;P98175-3 P98175-5 RBM10 RNA-binding protein 10 1 AHLS(1)ENELEALEK;AHLS(1)ENELEALEK;AHLS(1)ENELEALEK;AHLS(1)ENELEALEK 145.33 0.00041679 19987200.0 183055.0 153722.0 176440.0 185285.0 199177.0 153833.0 178331.0 192781.0 178649.0 155657.0 True False 172881.5359272253 165511.98310586467 165088.04249334664 160048.86336554668 174154.604595028 175022.09939306305 186623.74485617288 193341.96079338744 214383.79187012123 151162.77796454466 1.1436779493942273 1.0949255189308946 1.092120988488768 1.0587848776045004 1.1520997889829472 1.1578386012072006 1.2345879545819516 1.2790315406795179 1.4182313579894987 1.0 17.205743411238394 -7.05117859227641 1.7114438201063107 1.2602189163915933 1.1005293191354866 0.2489304776255915 0.09931951458145873 0.4265903013965043 2.499682923098234 0.04619651588466064 0.033621903647998254 8.888355322683958e-08 7.05117859227641 -0.15968959725610676 AHPS(ph)PGMDSR ddPTM_A459_Selumetinib_30min_R2 1 AHPSPGMDSR 10 0 A0A0X1KG68;Q5XG87-2;Q5XG87 A0A0X1KG68 PAPD7 Non-canonical poly(A) RNA polymerase PAPD7 1 AHPS(1)PGMDSR 71.268 0.047357 4290600.0 2212.7 2288.1 1178.6 2003.4 3139.5 878.48 1943.5 2568.7 2377.7 2152.9 True False 2089.7269921399097 2463.589912598902 1102.7701591626542 1730.533463942234 2745.0879425138924 999.4826459525462 2033.8766009721908 2576.174491728822 2853.306438488814 2090.7401830940316 0.999515391265584 1.1783338420143148 0.5274544240742021 0.8277133036115769 1.3129742111004479 0.47805205736919354 0.9728021766732918 1.2321829907704787 1.3647350644336307 1.0 11.02979807358559 -7.6902790933052705 4.794573891438846 1.224500950421476 0.8885050852114298 0.22651553432821125 0.255158169232508 0.2896686173447967 12.435275407684765 0.12787596954403938 0.06990327450663873 2.0404262717009925e-08 7.6902790933052705 -0.3359958652100463 AHQGTGAGIS(ph)PVILNSGEGK ddPTM_A459_Selumetinib_30min_R1 2 AHQGTGAGISPVILNSGEGK 20 0 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 AHQGTGAGIS(1)PVILNSGEGK;AHQGT(0.005)GAGIS(0.995)PVILNSGEGK 174.0 5.306599999999999e-10 14799600.0 7679.700000000001 9912.8 9677.3 9070.8 9688.0 7915.4 8994.4 8967.1 4604.4 7331.3 True False 7858.622067905089 8752.2047676643 8363.175813603882 7486.755060004247 8811.722110555325 7835.778262608173 8315.945166567015 8729.263378754178 7813.330507929519 8272.34376790934 0.9499873661429317 1.0580078649072189 1.0109802068486207 0.9050343252232088 1.065202602524617 0.9472258990257727 1.0052707430784993 1.0552346014218308 0.9445123083786171 1.0 13.014080424612917 AHQGTGAGIS(ph)PVILNSGEGK ddPTM_A459_Selumetinib_30min_R2 2 AHQGTGAGISPVILNSGEGK 20 0 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 AHQGTGAGIS(1)PVILNSGEGK;AHQGT(0.004)GAGIS(0.996)PVILNSGEGK 172.77 6.5826e-10 43580000.0 265740.0 220310.0 288290.0 262760.0 269870.0 196622.0 234100.0 247730.0 182529.0 222870.0 True False 250971.23464150593 237207.06859169833 269741.73526641936 226971.6347137171 235966.517931589 223704.89574319436 244986.11386034978 248450.85328609103 219039.9002863799 216435.16401419812 1.1595677429987405 1.0959728733180232 1.2462934869895925 1.048681880079467 1.0902411306700128 1.0335884964077249 1.1319145619252458 1.1479227713191407 1.0120347184989353 1.0 17.72357538592859 -4.395331694963884 0.015747088081787316 2.963627816511945e-07 2.305102120247419 0.33677116988016553 0.05931326483493781 3478.016171252977 7.6545515102627615 491.7190262446845 635.7741893500531 4.024095742499802e-05 4.395331694963884 2.305101823884637 AHS(ph)DSNLSASAAER ddPTM_A459_Selumetinib_30min_R2 1 AHSDSNLSASAAER 14 0 Q6PEV8 Q6PEV8 FAM199X Protein FAM199X 1 AHS(0.901)DS(0.099)NLSASAAER 98.552 0.0068226 2083200.0 10351.0 9877.9 14536.0 13493.0 16458.0 11543.0 10353.0 9965.1 10250.0 13485.0 True False 9775.732858336069 10635.503167545436 13600.769585600152 11655.230123276715 14390.398903613213 13132.94347307878 10834.43501408031 9994.096791188887 12300.286408928938 13095.653011762273 0.7464868570933948 0.8121399641539695 1.0385713162515984 0.890007555393244 1.0988683718702705 1.0028475450046679 0.8273306420343469 0.7631613927318 0.9392648383307841 1.0 13.676800380692098 -5.061748502509069 6.096938640290514 0.9377841494469522 0.7610468142204153 0.3366155003136493 0.09458286389951116 0.24100772159488912 18.215079911352905 0.026304697905307067 0.0743005699128157 8.674640738985697e-06 5.061748502509069 -0.1767373352265369 AHS(ph)GAAPWQPLAAPSGASAQAAEQLQR ddPTM_A459_Selumetinib_30min_R2 2 AHSGAAPWQPLAAPSGASAQAAEQLQR 27 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C3C1;H7C2I6;H7C224 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 AHS(1)GAAPWQPLAAPSGASAQAAEQLQR;AHS(1)GAAPWQPLAAPSGASAQAAEQLQR 92.424 1.0451e-05 7242700.0 25784.8 22196.4 20234.9 23748.9 24502.9 16865.2 20454.8 20330.4 19686.4 22281.2 True False 24351.784040732655 23898.792507325004 18933.00856409331 20514.2588508624 21424.62664329469 19188.22821295747 21405.988730417255 20389.558098121095 23624.230083974515 21637.883862489987 1.12542354860067 1.1044884360782794 0.8749935383891365 0.9480714001993776 0.9901442663917341 0.8867885757636828 0.9892829107713842 0.9423083249590359 1.0917994677348244 1.0 14.401271793207147 -5.157868529216025 7.088338312333278 0.9618466760887413 1.1189207769921605 0.5143738491021927 0.05811163122316151 0.18891990852467958 11.23234722736171 0.014421243429877231 0.03889473115837621 6.952347490536665e-06 5.157868529216025 0.15707410090341922 AHS(ph)IQIMK ddPTM_A459_Selumetinib_30min_R2 2 AHSIQIMK 8 0 M0R0P7;M0R3D6;M0R1A7;M0R117;Q02543 M0R0P7 RPL18A 60S ribosomal protein L18a 1 AHS(1)IQIMK;AHS(1)IQIMK 79.693 0.031715 12215100.0 235360.0 205268.0 246790.0 247560.0 252410.0 202340.0 202144.0 210140.0 183631.0 232410.0 True False 222279.63342072978 221011.39555935148 230911.80008463495 213841.90093517958 220699.99922596957 230210.4983403584 211544.0965407371 210751.4726094505 220362.3310788326 225699.71942630102 0.9848467423253132 0.9792276043635915 1.023092986874695 0.9474619706162575 0.977847911317568 1.019985753307639 0.9372811675550787 0.9337693159085576 0.9763518166480872 1.0 17.784045099512703 -7.277589458172663 24.801107395798454 0.9563313533902559 0.9875008832016549 0.18074222852839228 0.026969569201307452 1120.322096871086 1720432.0383529703 0.01111322563571162 0.007514579626676953 5.277284914028574e-08 7.277589458172663 0.031169529811398977 AHS(ph)LLFENSDSFSEDSSTLGR ddPTM_A459_Selumetinib_30min_R1 3 AHSLLFENSDSFSEDSSTLGR 21 0 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 AHS(1)LLFENSDSFSEDSSTLGR;AHS(1)LLFENSDSFSEDSSTLGR;AHS(0.997)LLFENS(0.003)DSFSEDSSTLGR 218.78 1.3405e-20 26984800.0 4338.8099999999995 5198.799999999999 6047.36 6134.2 5713.420000000001 4788.77 4995.04 4658.2 2551.59 3519.8 True False 4439.89583114539 4590.122079143448 5226.161727770715 5062.977123195097 5196.64216978623 4740.599321655271 4618.260111270225 4534.649404033936 4329.861869239829 3971.6006157553606 1.1179109534660407 1.1557360679556774 1.3158829986677167 1.2747951299811568 1.3084503384280692 1.1936243797649966 1.162820877041252 1.1417687332520188 1.090205760383671 1.0 11.955504837377568 -8.146872263295405 0.9353954009812027 1.0070468136808866 1.234200203399996 0.6011383462109525 0.06012999602235261 0.3996434175710728 0.6981351029101811 0.06246432453065427 0.022843185964603555 7.130627285987844e-09 8.146872263295405 0.22715338971910937 AHS(ph)LLFENSDSFSEDSSTLGR ddPTM_A459_Selumetinib_30min_R2 2 AHSLLFENSDSFSEDSSTLGR 21 0 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 AHS(1)LLFENSDSFSEDSSTLGR;AHS(1)LLFENSDSFSEDSSTLGR 185.58 8.300999999999998e-17 7910500.0 22091.0 19339.6 26001.0 22123.8 28758.0 19268.6 17370.3 23530.5 16610.4 16786.8 True False 20863.270657279692 20822.88513338481 24328.123967748325 19110.50027431626 25145.16294021806 21922.674747064517 18178.053368596477 23598.96985931602 19932.944133353492 16302.121466655612 1.2797886888496974 1.2773113717730529 1.4923287142418311 1.1722707571161772 1.542447281579273 1.3447743468176945 1.1150728698579446 1.4476011547077106 1.2227208694355745 1.0 13.992772100463977 -9.493022752539812 0.623683790490563 0.9813576940426378 1.3407769346650886 0.3725092871526414 0.1291589504801712 4.520426377678419 2.0593594763460965 0.32711880378212876 0.0501006776205213 3.2134921804707147e-10 9.493022752539812 0.3594192406224508 AHS(ph)NPMADHTLR ddPTM_A459_Selumetinib_30min_R2 1 AHSNPMADHTLR 12 0 F8VSD9;H0YHX0;Q9UBP6-2;Q9UBP6 F8VSD9 METTL1 tRNA (guanine-N(7)-)-methyltransferase 1 AHS(1)NPMADHTLR 115.26 0.0035061 14445000.0 66575.0 49421.0 61159.0 54571.0 63961.0 39227.0 41709.0 41455.0 38321.0 53919.0 True False 62875.02802084077 53211.43178643873 57224.09652488436 47138.3356597742 55925.647361405034 44630.1631827481 43648.55114481558 41575.62718675533 45986.27077820157 52362.218371613686 1.2007708988686818 1.016218056477252 1.0928508818852176 0.900235649399617 1.0680534381584401 0.8523352251046483 0.8335886542285629 0.7940004927158334 0.878233814538526 1.0 15.676238599176575 -5.538305377865288 0.6147602345491553 0.8585301516765528 1.209161032608815 0.5617741778388401 0.08302827450249246 1.1825001171790912 0.6242611767470795 0.04689498011719641 0.2610755580896464 2.895307011972973e-06 5.538305377865288 0.35063088093226213 AHS(ph)PAEGASVESS(ph)SPGPK ddPTM_A459_Selumetinib_30min_R2 1 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 2 AHS(1)PAEGASVES(0.045)S(0.872)S(0.084)PGPK 135.23 0.0014431 6324200.0 56320.0 42398.0 51966.0 51233.0 59846.0 40031.0 47281.0 37982.0 34854.0 52419.0 True False 53189.959866823236 45649.79026894295 48622.5641363028 44254.97701814541 52327.6104499718 45544.906884762735 49479.6601855241 38092.5213317414 41825.77390212774 50905.52726908169 1.044875924487851 0.896755081774177 0.9551529420231447 0.8693550463433545 1.0279357322707436 0.8946947282171691 0.9719899358664807 0.7482983356677168 0.8216352161729068 1.0 15.635534690678808 -7.737087895549401 24.999928800855653 0.8387249999447226 0.9471604684491279 0.2215689143784787 0.07910693602240249 268.5843501552431 275736.73517111875 0.03488644863173972 0.02012981710253889 1.831943623309294e-08 7.737087895549401 0.10843546850440533 AHS(ph)PAEGASVESSS(ph)PGPK ddPTM_A459_Selumetinib_30min_R2 1 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 2 AHS(0.93)PAEGAS(0.07)VESS(0.056)S(0.944)PGPK 188.9 2.8415999999999997e-13 0.0 22786.0 20896.0 22964.0 22956.0 23082.0 20200.0 22378.0 19025.0 16473.0 21632.0 True False 21519.64533958512 22498.656008770038 21486.52124131273 19829.353198691184 20182.23280430186 22982.366642657125 23418.62134116576 19080.35960024171 19768.06029407673 21007.427953314156 1.0243826796602273 1.070985751267119 1.022805899373464 0.9439210379661391 0.960718887107638 1.0940114465098714 1.1147781343442005 0.9082672872968998 0.9410033602404001 1.0 14.358611915851316 -7.783824820636375 24.999999205827592 0.943476484472181 1.030279050156808 0.32675836045635587 0.054485435677168535 308.96693915346714 345048.49865366676 0.032485854706106945 0.01562379128319874 1.6450351396491012e-08 7.783824820636375 0.08680256568462696 AHS(ph)PAEGASVESSSPGPK ddPTM_A459_Selumetinib_30min_R2 1 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 1 AHS(1)PAEGASVESSSPGPK 255.23 1.1455e-33 14232000.0 32512.0 24955.0 32238.0 39483.0 34713.0 22862.0 29478.0 29454.0 21129.0 30171.0 True False 30705.113195847942 26868.968257027944 30163.84217808047 34105.347288025965 30352.04260184258 26011.032979427095 30848.785409548884 29539.706263627806 25355.390393586298 29299.88483632776 1.047960200777919 0.9170332377455006 1.0294867145921858 1.1640096020357085 1.0359099624927635 0.8877520551608807 1.0528637085733765 1.0081850638198653 0.8653750871453652 1.0 14.838607373671875 -6.577235820181266 24.999796924623865 0.9681797596977917 1.0388697521577277 0.1994298754955096 0.07582647000967883 177.3721382831971 81575.24154597906 0.02621658540191519 0.026216588202001973 2.647062403912806e-07 6.577235820181266 0.07068999245993601 AHS(ph)PALGVHSFSGVQR ddPTM_A459_Selumetinib_30min_R2 2 AHSPALGVHSFSGVQR 16 0 Q9H1A4 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 AHS(1)PALGVHSFSGVQR;AHS(1)PALGVHSFSGVQR 132.51 0.00031964 13667300.0 30048.0 27649.0 34720.0 45868.0 53500.0 32121.0 35800.0 37027.0 29122.0 41517.0 True False 28378.05245167443 29769.58939445264 32486.153000277747 39620.6992732866 46778.8517039316 36545.37618459356 37464.77093635423 37134.74243985016 34947.21373666619 40318.29633587947 0.7038504855280963 0.738364268828505 0.8057422052173405 0.9826977544690528 1.1602387986394862 0.9064216374656592 0.9292250501917693 0.9210394737538488 0.8667829971170303 1.0 15.299147058077102 -5.609415586300959 3.3826550073120036 0.9672100175825405 0.7280471463374159 0.6440026069457733 0.07558214373681238 0.16002618666239365 3.613695224978623 0.02312033211677956 0.04413910169734102 2.4580143483597416e-06 5.609415586300959 -0.2391628712451247 AHS(ph)PASLSFASYR ddPTM_A459_Selumetinib_30min_R1 1 AHSPASLSFASYR 13 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 AHS(0.958)PAS(0.039)LS(0.003)FASYR 95.183 0.015204 10564000.0 1752.8 2042.5 2158.3 2239.0 2157.9 1966.5 2069.9 2106.2 767.49 1679.4 True False 1793.6368296449127 1803.3631504675122 1865.2147146932768 1848.0006812353402 1962.718326008189 1946.718795439141 1913.7657765139504 2050.33673409821 1302.374474748246 1894.9673487412786 0.9465265091962275 0.9516592207593372 0.9842991310284239 0.9752150518386843 1.0357531106337603 1.0273099411091373 1.0099201855827007 1.0819905342749756 0.6872806941044873 1.0 10.887957274897577 -8.24332806622831 24.962707044942597 0.843640281016421 1.0007392547826834 0.38487087404531706 0.07986512025828996 670.9117073516855 924716.859918216 0.05067589777907251 0.019067490323387244 5.710471044875497e-09 8.24332806622831 0.15709897376626247 AHS(ph)PASLSFASYR ddPTM_A459_Selumetinib_30min_R2 4 AHSPASLSFASYR 13 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 AHS(1)PASLSFASYR;AHS(1)PASLSFASYR;AHS(1)PASLSFASYR;AHS(1)PASLSFASYR 141.06 0.00056134 53851000.0 96640.0 71448.0 102148.0 146052.0 172762.0 93492.0 80600.0 97142.0 103606.0 105192.0 True False 91269.13568057172 76927.83185847056 95575.90889033336 126159.4656462469 151058.09304812382 106369.67436412383 84348.05970587004 97424.66713727616 124330.09499351121 102154.83363836115 0.8934392277870479 0.7530513155236802 0.9355984977537346 1.234982830992263 1.4787170383232706 1.0412593371810839 0.8256883859697823 0.9536961068545198 1.2170750082531858 1.0 16.640397943814946 -5.554224935664827 6.214286225448478 1.1058770742790742 0.8273371222212386 0.3154347080905956 0.17179004748941284 0.21961684278402904 25.58681132409177 0.05242623826583678 0.09378195782130906 2.7910978636998443e-06 5.554224935664827 -0.27853995205783566 AHS(ph)PGLLGPALGPPYPSGR ddPTM_A459_Selumetinib_30min_R1 1 AHSPGLLGPALGPPYPSGR 19 0 Q6UXY1;Q6UXY1-2 Q6UXY1 BAIAP2L2 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 1 AHS(1)PGLLGPALGPPYPSGR 130.49 0.00018958 15177000.0 1687.1 2293.1 2215.7 2032.3 2170.2 1924.1 1898.0 2287.4 1042.5 2077.3 True False 1726.4061474748587 2024.6227859667315 1914.8201099689072 1677.3969559957932 1973.9057931799307 1904.7453009430194 1754.8323319114345 2226.730721477658 1769.0463588125535 2343.9416896154935 0.7365397164628541 0.8637684098271472 0.8169230994321448 0.7156308381847835 0.8421309292483874 0.8126248657898477 0.7486672299426108 0.9499940767907655 0.7547313854478832 1.0 11.194720964853591 -14.52287873176427 0.22692248612788618 2.0223562633316416 0.7857323567670259 0.4429348265156623 0.06625733664079894 144.48430940267275 1.4426586105907167 67.63099112542317 0.11241166310318124 3.0000000933656946e-15 14.52287873176427 -1.2366239065646156 AHS(ph)PGLLGPALGPPYPSGR ddPTM_A459_Selumetinib_30min_R2 4 AHSPGLLGPALGPPYPSGR 19 0 Q6UXY1;Q6UXY1-2 Q6UXY1 BAIAP2L2 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 1 AHS(1)PGLLGPALGPPYPSGR;AHS(1)PGLLGPALGPPYPSGR;AHS(1)PGLLGPALGPPYPSGR;AHS(1)PGLLGPALGPPYPSGR 130.83 0.00018497 17467400.0 77482.0 58337.4 82325.0 92104.0 80872.0 67525.5 76129.9 78124.0 68007.7 72778.6 True False 73175.8606250213 62811.69099569394 77028.29912868269 79559.27631173775 70712.13635514695 76826.52468954177 79670.09119853505 78351.3279058756 81611.140293904 70677.29271648814 1.0353517772469838 0.88871104963873 1.0898592202402362 1.1256695503445273 1.0004929962272124 1.0870043508559446 1.127237449772167 1.1085785107838066 1.1547009959942216 1.0 16.10895915827173 -5.285352022150361 23.801019547750087 1.0903433093594468 0.9620314313107792 0.42077205327154277 0.058379521119783465 323.2101715944794 321701.13884440484 0.01483159672704932 0.030906734810051847 5.1837969025565026e-06 5.285352022150361 -0.12831187804866762 AHS(ph)PMIAVGSDDSSPNAMAK ddPTM_A459_Selumetinib_30min_R2 2 AHSPMIAVGSDDSSPNAMAK 20 0 Q96EE3;Q96EE3-1;K7ENI5;K7EP88;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 1 AHS(1)PMIAVGSDDSSPNAMAK;AHS(1)PMIAVGSDDSSPNAMAK 135.54 7.2987e-05 4025600.0 33251.0 29445.0 38551.0 39608.0 36626.0 29770.0 33826.0 29544.0 25688.0 32902.0 True False 31403.042534299348 31703.336819402426 36070.67063115515 34213.32207238895 32024.71443940558 33870.547274846664 35398.9760249474 29629.96814872751 30826.317782689435 31952.033770337606 0.982818269410196 0.9922165533273173 1.1289006167939473 1.0707713417651241 1.0022746805286444 1.0600435489740279 1.1078786495841066 0.927326515792376 0.9647685654146616 1.0 14.963620142239693 -7.771812259485899 24.985091451438475 0.9595356470367157 1.0495737613250604 0.3985203292667242 0.047892280399831594 218.83382766695087 527095.1222112768 0.026954930970565935 0.013171046526670631 1.6911718478053056e-08 7.771812259485899 0.09003811428834474 AHS(ph)SPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR ddPTM_A459_Selumetinib_30min_R1 1 AHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR 37 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 AHS(0.654)S(0.234)PAS(0.112)LQLGAVSPGTLTPTGVVSGPAATPTAQHLR 89.25200000000002 1.2295999999999998e-09 14539000.0 1991.9 2327.8 1999.7 1835.2 2684.5 2068.5 2817.2 2027.2 909.89 1774.5 True False 2038.3073944373004 2055.2600938351407 1728.1517235658362 1514.7167709705645 2441.687448986969 2047.692768047731 2604.696335859266 1973.4320707263755 1544.0168742637445 2002.2743600937251 1.0179960524200533 1.0264627739322074 0.8630943680889679 0.7564981109280456 1.2194569823451542 1.022683408857056 1.300868845834565 0.985595236126382 0.7711315217518293 1.0 10.967423956551814 AHS(ph)SPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR ddPTM_A459_Selumetinib_30min_R2 2 AHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR 37 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 AHS(0.583)S(0.304)PAS(0.112)LQLGAVS(0.001)PGTLTPTGVVSGPAATPTAQHLR;AHS(0.509)S(0.218)PAS(0.267)LQLGAVS(0.004)PGT(0.002)LTPTGVVSGPAATPTAQHLR 74.407 1.5235e-06 17222900.0 5439.41 5324.8 8464.64 17029.1 19588.5 9754.300000000001 7807.0599999999995 8726.3 11920.92 11418.32 True False 5137.10936788347 5733.195038069419 7920.034278003194 14709.70720316398 17127.617506588114 11097.866284280717 8170.103759395907 8751.692088283262 14305.43709833455 11088.643433241781 0.4632766306186138 0.517033041290003 0.7142473581809241 1.3265560653764819 1.5446089153919913 1.0008317384443337 0.736799213409946 0.7892482196737651 1.29009803448539 1.0 13.436795258859279 -5.568975625950296 5.051215933422608 1.088061703050361 0.5150393668922839 0.537865354775758 0.232127615424858 0.1640690503351659 9.434405270238496 0.07215921783175108 0.13089517754530247 2.6978908427966036e-06 5.568975625950296 -0.5730223361580771 AHS(ph)VDVEK ddPTM_A459_Selumetinib_30min_R1 1 AHSVDVEK 8 0 Q6IQ19;Q6IQ19-2 Q6IQ19 CCSAP Centriole, cilia and spindle-associated protein 1 AHS(1)VDVEK 72.096 0.042426 0.0 2613.2 3051.0 2655.6 2907.9 3176.4 2660.5 2327.3 2290.9 1592.2 2142.4 True False 2674.0824755979497 2693.7875016285807 2294.984106166643 2400.089853043432 2889.0951808389673 2633.7377855407226 2151.749887280022 2230.1378901080566 2701.8471103130437 2417.3979087431917 1.106182174612788 1.1143335120319866 0.949361335122445 0.9928402123468543 1.1951260363011613 1.0894928700050073 0.8901099316325294 0.9225365348592977 1.1176675137101189 1.0 11.239239247927816 -7.229993962249049 24.8409659548067 0.9761231770158438 1.0724395336893653 0.2217075034110657 0.08402111408564217 982.850236759739 776424.3540928757 0.03382549174946736 0.026198200172490475 5.8885184177333574e-08 7.229993962249049 0.09631635667352145 AHS(ph)VDVEK ddPTM_A459_Selumetinib_30min_R2 1 AHSVDVEK 8 0 Q6IQ19;Q6IQ19-2 Q6IQ19 CCSAP Centriole, cilia and spindle-associated protein 1 AHS(1)VDVEK 98.04 0.013085 4620400.0 58366.0 56663.0 55690.0 67700.0 64147.0 51684.0 61502.0 69547.0 47090.0 65564.0 True False 55122.25137761014 61008.869899738485 52106.966030687385 58479.14321098598 56088.28037854392 58803.001859360935 64361.96486390102 69749.37025587437 56509.31580453303 63670.99696427003 0.8657356411199726 0.9581893296562415 0.8183783593011433 0.9184581049328073 0.8809078395618452 0.9235445440309212 1.0108521608357843 1.0954653387163908 0.8875205116741631 1.0 15.9583487337531 -7.135527528551106 3.542461820132232 1.0063523433378627 0.8907411022209406 0.4436921288220568 0.05788978333690001 0.2182963943619075 4.987460671857965 0.022480070538851264 0.017008942720416493 7.319349266935599e-08 7.135527528551106 -0.11561124111692211 AHSAPSSGT(ph)SSRPGSIR ddPTM_A459_Selumetinib_30min_R1 1 AHSAPSSGTSSRPGSIR 17 1 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 AHSAPSS(0.006)GT(0.464)S(0.346)S(0.066)RPGS(0.117)IR 105.01 0.0037377 15541000.0 579.19 617.76 535.83 934.48 970.35 571.24 828.81 474.32 149.18 251.37 True False 592.6840000924443 545.4323720111677 463.06722910350703 771.2906103621257 882.5820138292069 565.4938442444217 766.2921944212403 461.7394927915028 253.14756432389137 283.6357880511465 2.08959526639695 1.9230026498377306 1.632612133628231 2.7192993368772034 3.1116736709898385 1.9937323429103002 2.701676680811023 1.6279310025159444 0.8925092494965503 1.0 8.147895767438406 -8.018409155974746 3.725470384696766 0.9836522324425719 2.3025550006969557 0.6309956902998897 0.4186617121653268 0.16165202788761782 4.765070664739131 0.3199384911061461 0.12053966943608954 9.58497190040967e-09 8.018409155974746 1.3189027682543837 AHSAPSSGTSS(ph)RPGSIR ddPTM_A459_Selumetinib_30min_R2 2 AHSAPSSGTSSRPGSIR 17 1 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 AHSAPS(0.014)S(0.049)GT(0.019)S(0.205)S(0.708)RPGS(0.005)IR;AHSAPS(0.231)S(0.197)GT(0.05)S(0.125)S(0.385)RPGS(0.012)IR 65.374 0.02397 15264300.0 4179.01 4193.59 5722.5 8877.7 8477.6 4997.7 4965.21 6065.3 5607.3 6043.6 True False 3946.7573541025026 4515.224868482862 5354.320580186903 7668.541945113294 7412.568097294404 5686.087810396413 5196.102103376965 6082.949018835531 6728.9166810524175 5869.1055648414185 0.6724631735618036 0.7693207795632591 0.9122890227536016 1.3065946523523633 1.2629808776483797 0.9688167553943204 0.8853311711590183 1.0364354417605182 1.1464978107331472 1.0 12.518924942087851 -5.403513786704321 3.235681366065657 1.083270101366226 0.7166226290802671 0.5737699649502914 0.12525818180177833 0.19758813329671077 3.8340250254909525 0.03807102073469324 0.08995078740117758 3.948991630524276e-06 5.403513786704321 -0.36664747228595895 AHSENEGTALPSADSCTS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 AHSENEGTALPSADSCTSPTK 21 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4 Q8IVL0-3 NAV3 Neuron navigator 3 1 AHSENEGTALPSADS(0.001)CT(0.08)S(0.894)PT(0.025)K;AHSENEGTALPSADS(0.01)CT(0.351)S(0.548)PT(0.09)K 182.62 1.0126999999999999e-14 19721000.0 118727.0 87887.0 102224.0 109875.0 106371.0 102644.0 117465.0 120534.0 103839.0 106677.0 True False 112128.62864183798 94627.65029875451 95647.01913307582 94909.83545505283 93007.72401119453 116782.27929053965 122927.35525248181 120884.73398452201 124609.70150407506 103596.95782986753 1.0823544531682254 0.9134211301277505 0.9232608865807862 0.9161450050581489 0.8977843168323223 1.1272751800523502 1.1865923269133027 1.1668753264265288 1.2028316672070214 1.0 16.66062211271027 -6.818030913452082 6.286215120323116 1.1523147774907652 0.9419078004603733 0.6363644069230077 0.07142691190692313 0.11783286179425298 9.54604698029257 0.02448671467835983 0.02176538458466642 1.520439299712875e-07 6.818030913452082 -0.2104069770303919 AHSLGGLDPAFTS(ph)TEDLNCK ddPTM_A459_Selumetinib_30min_R1 2 AHSLGGLDPAFTSTEDLNCK 20 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 AHSLGGLDPAFT(0.065)S(0.706)T(0.229)EDLNCK;AHSLGGLDPAFT(0.133)S(0.734)T(0.133)EDLNCK 215.08 7.8635e-18 29393400.0 6960.6 9161.8 6132.4 5442.5 6528.3 5968.1 9333.1 8500.9 4156.8 8264.3 True False 7122.768437030107 8089.132196794729 5299.653762861999 4492.069543377996 5937.816417664978 5908.066332601237 8629.096752878086 8275.428517185203 7053.785999340069 9325.10340609894 0.7638272871453168 0.8674576403629107 0.5683211790869624 0.4817179335984657 0.6367560936408962 0.6335657713711954 0.925362044482462 0.8874355765076863 0.7564297887277742 1.0 13.186904008168192 -7.258206693480002 24.865557716040293 0.8829264887201687 0.6549632010261838 0.5073808291185653 0.11262509782471122 252.6136106607322 1943093.430802572 0.048627778629543116 0.03607517621404225 5.518147519525117e-08 7.258206693480002 -0.22796328769398488 AHSLGGLDPAFTS(ph)TEDLNCK ddPTM_A459_Selumetinib_30min_R2 3 AHSLGGLDPAFTSTEDLNCK 20 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 AHSLGGLDPAFT(0.158)S(0.684)T(0.158)EDLNCK;AHSLGGLDPAFT(0.035)S(0.804)T(0.16)EDLNCK;AHSLGGLDPAFT(0.184)S(0.737)T(0.079)EDLNCK 189.11 9.2119e-16 35261900.0 114353.0 92235.0 122628.0 142030.0 147882.0 132872.0 147146.0 169227.0 127455.0 106821.0 True False 107997.71805132889 99309.12791773099 114738.24798727121 122685.26898458395 129303.74107814611 151173.91190807606 153988.58056426753 169719.42255296215 152949.56139024763 103736.80017571078 1.0410743137285987 0.9573182106014438 1.1060515438390814 1.18265908314868 1.2464597024308606 1.4572833522146014 1.4844161406891248 1.6360580070475388 1.4744002237506806 1.0 16.66256824913676 -6.249648785646728 1.239602951079501 1.4576451538442703 1.011963975289274 0.49574033405636 0.16094033988632472 0.3291831528334837 1.0340965815733978 0.06245966840430071 0.09136036051778203 5.627962750798262e-07 6.249648785646728 -0.44568117855499634 AHSLGGLDPAFTST(ph)EDLNCK ddPTM_A459_Selumetinib_30min_R2 1 AHSLGGLDPAFTSTEDLNCK 20 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 AHSLGGLDPAFT(0.015)S(0.416)T(0.568)EDLNCK 171.39 2.0576e-09 9695300.0 55163.0 39113.0 49623.0 57627.0 63702.0 60301.0 62154.0 69110.0 58265.0 48888.0 True False 52097.26129498525 42112.84133188276 46430.31020543728 49778.10318788017 55699.185256894445 68606.91539202313 65044.284155814494 69311.09865822358 69919.62806012144 47476.476413721495 1.097327881728145 0.8870254179122578 0.97796453554877 1.0484793090814437 1.1731954320181277 1.4450717613111361 1.3700318361666708 1.4599040176071598 1.472721510560828 1.0 15.534925245256177 -6.455647222840352 2.292674146957574 1.3797332017949697 0.9858889980317452 0.5750887647017893 0.1385708485537602 0.191491669299867 1.99401346432599 0.04615822733519795 0.05184437717913228 3.502295427711896e-07 6.455647222840352 -0.3938442037632245 AHSPAEGAS(ph)VESSS(ph)PGPK ddPTM_A459_Selumetinib_30min_R1 1 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 2 AHS(0.041)PAEGAS(0.946)VES(0.014)S(0.159)S(0.839)PGPK 110.84 0.024547 3075900.0 1290.8 1318.8 1326.2 1693.7 1525.4 1073.8 1533.9 1494.0 622.41 1184.2 True False 1320.8731285404235 1164.394282906513 1146.1093242951501 1397.9270896865992 1387.4278393312445 1062.9985469323922 1418.1966880500242 1454.3742668040672 1056.1843109722026 1336.2036050848055 0.9885268409050513 0.8714198034457569 0.8577355426476412 1.046193173231168 1.0383356503840504 0.7955363560517608 1.0613627164701556 1.0884376162955807 0.790436657222736 1.0 10.38392414102613 -5.749492232412692 24.999662188388903 0.9768574588286745 0.9024466491801882 0.0837515982267234 0.10330318575101984 563.7254612225988 1179597.6761549665 0.027918718006006482 0.04787179863009678 1.780359751248036e-06 5.749492232412692 -0.07441080964848623 AHSPAEGASVESS(ph)SPGPK ddPTM_A459_Selumetinib_30min_R1 2 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 1 AHSPAEGASVES(0.018)S(0.809)S(0.172)PGPK;AHSPAEGASVES(0.001)S(0.746)S(0.253)PGPK 160.76 7.9871e-06 15339600.0 8175.3 9079.6 9673.7 10338.3 8746.2 8679.6 8026.2 7510.299999999999 4539.7 7366.1 True False 8365.768583635354 8016.556211008473 8360.064673830491 8532.909978926002 7955.107754267029 8592.29110444625 7420.7772720693065 7311.102447107484 7703.539333430547 8311.61068689005 1.0065159328059876 0.964500926836363 1.0058296747484659 1.0266253197331545 0.9571078403388967 1.033769678120141 0.8928206038059675 0.8796252281930538 0.9268407320354144 1.0 13.020912365125715 -7.267691290551589 24.995695338364854 0.9147904077335545 0.9971414493913298 0.47468414620762067 0.03763978656197977 396.7401643468805 1586194.9826031167 0.014768983778632817 0.010226140729032798 5.398942590629751e-08 7.267691290551589 0.08235104165777529 AHSPAEGASVESSS(ph)PGPK ddPTM_A459_Selumetinib_30min_R1 2 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 1 AHSPAEGAS(0.001)VES(0.009)S(0.114)S(0.875)PGPK;AHSPAEGASVESS(0.376)S(0.623)PGPK 198.95 1.4701e-21 7247900.0 5080.67 6266.7 6746.099999999999 6708.4 6390.6 4955.78 6196.99 5367.41 2953.4300000000003 4645.67 True False 5199.039725737119 5532.991850690209 5830.016673674796 5536.903872264021 5812.571358352067 4905.92935268822 5729.546055074728 5225.048850995193 5011.755000007442 5241.986997157851 0.9918070625806554 1.0555142265118431 1.1121768666797092 1.0562605125243674 1.1088488699997885 0.9358911716774884 1.0930103524066783 0.9967687546398262 0.9560792506209499 1.0 12.3558980597021 -6.7478295188651 24.997205852846754 1.0021892165213573 1.0665430033214751 0.320888891837702 0.04948665469413071 310.5041270686026 570301.7685393045 0.016368455628807337 0.01628393860486776 1.787188993422502e-07 6.7478295188651 0.06435378680011783 AHSPAEGASVESSS(ph)PGPK ddPTM_A459_Selumetinib_30min_R2 2 AHSPAEGASVESSSPGPK 18 0 C9J4C4;Q8NFG4-3;Q8NFG4-2;Q8NFG4 C9J4C4 FLCN Folliculin 1 AHSPAEGASVESS(0.032)S(0.968)PGPK;AHSPAEGASVESS(0.16)S(0.84)PGPK 182.98 5.0308e-10 15654200.0 99467.0 93991.0 100677.0 127694.0 133729.0 85754.0 85408.0 97897.0 82737.0 113769.0 True False 93939.02233794924 101199.80747130094 94199.55142882974 110301.85691556346 116928.76746757141 97565.835102694 89379.6412327414 98181.86406227932 99286.71186493222 110484.19336263879 0.8502485240546233 0.9159663875097137 0.8526065906970196 0.9983496603312579 1.0583302815433497 0.8830750547497481 0.8089812534483862 0.8886507750481563 0.8986508281691171 1.0 16.75348045682712 -7.128951893854011 0.005565615075797676 1.8301098869483818 2.3062578354084747e-07 0.055525315717030344 0.072739386192882 35483.90860217795 104.26893171218734 16961.367415884397 17318.054872560664 7.431014455665558e-08 7.128951893854011 -1.8301096563225983 AHSPAS(ph)LSFASYR ddPTM_A459_Selumetinib_30min_R1 1 AHSPASLSFASYR 13 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 AHS(0.249)PAS(0.741)LS(0.01)FASYR 161.25 0.00036371 11940000.0 1881.4 1910.1 1778.5 1882.3 2282.4 1526.4 2267.5 1604.0 676.69 1337.9 True False 1925.2329594328728 1686.4646040186003 1536.9894686012099 1553.5916401470654 2075.9573229904495 1511.0458018603122 2096.460649425276 1561.4567094737095 1148.2935065178574 1509.6324972495888 1.2752990962638058 1.1171358639213076 1.0181216099954544 1.0291191021507327 1.3751408549912991 1.0009361911679155 1.3887225223654327 1.0343290253214206 0.7606444009452249 1.0 10.559981669361333 -8.002404221063966 24.98185873493634 0.8860436555253745 1.1634618251697917 0.4004706890706332 0.14300399009706632 85.49576088592875 888365.038686363 0.07738398962416965 0.036175031406771904 9.94479371405827e-09 8.002404221063966 0.27741816964441723 AHSS(ph)PASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR ddPTM_A459_Selumetinib_30min_R1 1 AHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLR 37 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 AHS(0.081)S(0.837)PAS(0.081)LQLGAVSPGTLTPTGVVSGPAATPTAQHLR 82.581 2.6006e-07 41480000.0 1925.7 2303.6 2186.4 2210.6 3259.2 2062.4 2379.6 2130.7 1066.0 1553.8 True False 1970.565063240077 2033.8934410854151 1889.4988890355273 1824.5602081013144 2964.4059354584942 2041.6541285093729 2200.104856173048 2074.186914510995 1808.9241424404627 1753.2453652936754 1.1239528147333786 1.1600734736548013 1.077715034323806 1.040675905506069 1.69081064986129 1.1644999433193357 1.2548756150879783 1.1830556952098719 1.0317575498837614 1.0 10.775812198911915 -8.254744399442838 3.1110100341141282 1.001696400628101 1.218402019559084 0.17742931790446992 0.17065356780178007 0.463351078594111 8.575457392512178 0.15914916201173082 0.04619665480687856 5.5623152658838174e-09 8.254744399442838 0.21670561893098284 AHSTMT(ph)GSGVDAR ddPTM_A459_Selumetinib_30min_R2 1 AHSTMTGSGVDAR 13 0 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 AHS(0.001)T(0.004)MT(0.949)GS(0.047)GVDAR 85.493 0.044633 988890.0 3665.2 2451.8 3439.0 3460.1 3912.7 2967.1 2712.5 948.72 2106.8 4476.8 True False 3461.5028569581063 2639.8451762204427 3217.7384841000903 2988.8284109945735 3421.1516460181933 3375.7910923479185 2838.636624716782 951.4806181309492 2528.218868910388 4347.543151876703 0.7961974697051323 0.6072039043662859 0.7401280152242055 0.6874752720290739 0.7869160872023515 0.7764824808905443 0.6529289130785116 0.2188547841601581 0.5815281828356397 1.0 12.085984631846523 -7.532191232864335 24.999325577542212 0.5272932744778577 0.726431042858356 0.05425283637049161 0.18667581176680836 335.2807646192411 900046.0291252375 0.08226512664473788 0.0475748510642567 2.936356401607908e-08 7.532191232864335 0.19913776838049835 AHSTMTGS(ph)GVDAR ddPTM_A459_Selumetinib_30min_R1 3 AHSTMTGSGVDAR 13 0 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 AHSTMT(0.028)GS(0.972)GVDAR;AHSTMT(0.156)GS(0.844)GVDAR;AHST(0.002)MT(0.431)GS(0.567)GVDAR 164.22 1.3739e-06 4481300.0 1621.1 2042.17 1888.43 1928.56 2561.36 1489.46 2156.83 1924.52 721.05 1173.0500000000002 True False 1658.8684758885026 1803.0717870209244 1631.9915784034777 1591.7731995548118 2329.6854402448375 1474.4773847214765 1994.1385766262056 1873.4754778780198 1223.569186591647 1323.6223939746098 1.2532792459843525 1.3622252050349577 1.2329736833047138 1.202588598380382 1.7600831255575797 1.1139713194892957 1.506576638249638 1.4154153680131505 0.9244095537832959 1.0 10.370275890161057 -8.263227944003962 24.964062012837772 0.9622047251025669 1.3573252750737228 0.45235397099549546 0.1732624555554253 138.13327855131757 1927925.4808868058 0.1364949894954421 0.042235779758346526 5.454714895253465e-09 8.263227944003962 0.39512054997115587 AHSTMTGS(ph)GVDAR ddPTM_A459_Selumetinib_30min_R2 3 AHSTMTGSGVDAR 13 0 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 AHST(0.001)MT(0.215)GS(0.783)GVDAR;AHST(0.002)MT(0.123)GS(0.875)GVDAR;AHST(0.007)MT(0.161)GS(0.832)GVDAR 117.27 0.0036493 6694400.0 13805.699999999999 10279.4 17945.899999999998 20502.5 19256.5 12984.0 14046.600000000002 16367.1 14419.399999999998 16373.599999999999 True False 13038.434462595906 11067.79692651946 16791.28033201854 17710.024131214766 16837.326314705788 14772.428142983183 14699.79473280986 16414.725551280728 17303.682911698535 15900.85162427815 0.8199834053346065 0.6960505756572586 1.055998806150788 1.113778340285516 1.0588946248009625 0.9290337707716209 0.924465876429256 1.0323173839455222 1.0882236574850166 1.0 13.956816415576084 -5.265350599653326 24.983322453542396 1.0238081259721397 0.7580169803454572 0.7328127225572112 0.06456104468327503 163.1192427209546 1041947.8593235508 0.018457143236102428 0.040880695037395026 5.428119503309349e-06 5.265350599653326 -0.2657911456266825 AHT(ph)PLNTPDPSTK ddPTM_A459_Selumetinib_30min_R1 2 AHTPLNTPDPSTK 13 0 Q9BYW2;H7C3H4;A0A1W2PPX9 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 AHT(1)PLNTPDPSTK;AHT(1)PLNTPDPSTK 221.85 2.0971000000000003e-08 30587000.0 13308.4 15491.2 16548.0 16730.0 13753.599999999999 12598.2 14319.8 13874.6 7743.299999999999 12749.7 True False 13618.459826361457 13677.483102336495 14300.87249165749 13808.419560994742 12509.589308395296 12471.47354625038 13239.64595706287 13506.6005369476 13139.814551744113 14386.248187594787 0.9466303965271925 0.9507331532157594 0.994065464822794 0.9598346546601146 0.8695518904770649 0.8669024323523411 0.9202987314287663 0.9388549648819695 0.9133593679465736 1.0 13.812402777959415 -6.1027813420642305 9.616280673667129 0.9126941397445651 0.9648864536304046 0.25183192543232724 0.03702509680066125 0.5001360384514502 43.46454055642243 0.01102013431416279 0.01424414887664098 7.892573917310351e-07 6.1027813420642305 0.05219231388583945 AHT(ph)PLNTPDPSTK ddPTM_A459_Selumetinib_30min_R2 5 AHTPLNTPDPSTK 13 0 Q9BYW2;H7C3H4;A0A1W2PPX9 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 AHT(1)PLNTPDPSTK;AHT(1)PLNTPDPSTK;AHT(1)PLNTPDPSTK;AHT(1)PLNTPDPSTK;AHT(1)PLNTPDPSTK 167.03 0.00049476 60274100.0 496197.0 412755.0 467515.0 482006.0 487888.0 355151.0 379789.0 424670.0 340360.0 414210.0 True False 468620.3571739712 444411.98128349264 437435.5938918438 416355.9512932725 426595.14766594046 404069.8265102144 397449.9410376266 425905.7193920971 408441.51045297994 402250.68105317414 1.1649958079549492 1.1048134962007563 1.087470113777181 1.0350658703750804 1.0605206349160865 1.0045224173450182 0.988065302952432 1.0588067079886334 1.0153904758684236 1.0 18.617735338023707 -4.23554526915113 0.5336806706558609 1.013994732422437 1.3716988518672102 0.8342618905891895 0.021390553275017536 2.8239062550495713 0.3993540607591542 0.0121158966522897 0.7122372770696929 5.813728291295793e-05 4.23554526915113 0.3577041194447732 AHT(ph)PTPGIYMGR ddPTM_A459_Selumetinib_30min_R1 2 AHTPTPGIYMGR 12 0 Q13595;Q13595-4;Q13595-3;Q13595-2 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(0.995)PT(0.005)PGIYMGR;AHT(1)PTPGIYMGR 164.48 0.0011940999999999998 254040000.0 4699.1 8507.3 3728.4 4182.9 5007.3 4849.1 6088.0 5609.9 3041.8 5972.5 True False 4808.579887143091 7511.261361063531 3222.103758635229 3452.435037757615 4554.390599110617 4800.322456630532 5628.7772585230805 5461.107228476661 5161.712435718006 6739.128552076512 0.7135314083987067 1.1145745778583054 0.47811875582079666 0.5122969551743933 0.6758129873791 0.7123061119158232 0.8352381491207344 0.8103580731953751 0.7659317366972529 1.0 12.718346330834564 -7.243891641506453 4.4325099772550685 0.8383789451497697 0.6989168979513833 0.15871802490367737 0.17008262303908175 0.48479119386073194 24.485666003937045 0.07453887011283723 0.05387600797854599 5.703065486676241e-08 7.243891641506453 -0.1394620471983864 AHT(ph)PTPGIYMGR ddPTM_A459_Selumetinib_30min_R2 5 AHTPTPGIYMGR 12 0 Q13595;Q13595-4;Q13595-3;Q13595-2 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(1)PTPGIYMGR;AHT(1)PTPGIYMGR;AHT(0.999)PT(0.001)PGIYMGR;AHT(0.984)PT(0.016)PGIYMGR;AHT(0.999)PT(0.001)PGIYMGR 158.06 0.0010536 790601200.0 380945.1 277764.0 322325.0 334330.0 382795.0 347450.0 359651.7 404916.0 355476.0 291202.0 True False 359773.69638606143 299067.60564797034 301586.9604209248 288793.6772485815 334704.86986928 395308.0836629317 376376.2166863234 406094.2385225477 426581.1328293095 282794.24162633973 1.2722101211008243 1.0575448917490082 1.0664536826722808 1.021214843653602 1.1835632435243522 1.3978646856086205 1.3309189554985172 1.436006038125508 1.5084505624161808 1.0 18.10939321812831 -6.618272129956619 4.1646551090345945 1.3610273455166004 1.0983275408378497 0.36686304586939855 0.14126457947665805 0.20549263476333415 6.578987719555099 0.046008937107635976 0.0460490786374587 2.4083958492083075e-07 6.618272129956619 -0.26269980467875076 AHT(ph)PTPGIYMGRPTHSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R1 6 AHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGR 33 1 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(0.773)PT(0.214)PGIY(0.006)MGRPT(0.006)HSGGGGGGGGGGGGGGGGR;AHT(0.824)PT(0.175)PGIY(0.001)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.958)PT(0.04)PGIY(0.001)MGRPT(0.001)HSGGGGGGGGGGGGGGGGR;AHT(0.797)PT(0.202)PGIY(0.001)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.779)PT(0.201)PGIY(0.02)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.776)PT(0.184)PGIY(0.04)MGRPTHSGGGGGGGGGGGGGGGGR 95.47 1.2591e-10 61095800.0 6798.060000000001 7998.110000000001 9011.279999999999 8934.970000000001 8071.299999999999 6797.700000000001 7214.9490000000005 6269.64 3991.89 5314.8 True False 6956.441571277893 7061.68756297954 7787.59767141789 7374.645219659365 7341.252340103754 6729.321309817767 6670.719588141237 6103.348780539122 6773.945773889925 5997.006350535999 1.1599856936379833 1.177535448557326 1.2985808612195069 1.2297210955930094 1.2241528374315644 1.1221134206763537 1.112341591491732 1.017732585858212 1.1295545440408754 1.0 12.55002678520998 -7.04273095909468 1.7109091152609952 1.059252826635193 1.2222548293225022 0.6848383474871698 0.04936323555500687 0.21904521401109148 1.2845800219135115 0.02413693870420565 0.017683616853099132 9.062938666360956e-08 7.04273095909468 0.16300200268730913 AHT(ph)PTPGIYMGRPTHSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R2 3 AHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGR 33 1 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(0.497)PT(0.497)PGIY(0.003)MGRPT(0.002)HSGGGGGGGGGGGGGGGGR;AHT(0.702)PT(0.295)PGIY(0.003)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.499)PT(0.499)PGIY(0.003)MGRPTHSGGGGGGGGGGGGGGGGR 72.23100000000002 7.0541e-05 106882500.0 100969.7 94146.0 127838.9 120036.4 120450.0 87131.6 69907.2 48692.1 74165.2 106906.8 True False 95358.20828773394 101366.69547289742 119613.88435447027 103687.23524566024 105317.99416333776 99133.18699808637 73158.02331848892 48833.785949588906 89000.31234882897 103820.12290677539 0.9184944654068675 0.9763684788152196 1.1521262064183528 0.998720020190744 1.0144275619660688 0.9548552267377142 0.7046613052479306 0.47036917875197365 0.8572549314813105 1.0 16.663726575205317 -7.184795064911697 3.9829903402957103 0.7132663873927573 1.0139159334423342 0.4165541509134081 0.13874380839040137 0.19117601418577773 5.792859240854293 0.054738826921755954 0.04096449006852374 6.534388249338562e-08 7.184795064911697 0.30064954604957694 AHT(ph)QPVT(ph)KAPGPGET(ph)KIPVT(ph)LSR ddPTM_A459_Selumetinib_30min_R1 1 AHTQPVTKAPGPGETKIPVTLSR 23 2 Q8IZ57 Q8IZ57 NRSN1 Neurensin-1 4 AHT(1)QPVT(1)KAPGPGET(0.944)KIPVT(0.528)LS(0.528)R 44.415 0.028352 100470000.0 4007.0 3554.8 6785.2 9624.9 5838.8 3705.7 3430.8 2689.9 1898.5 2098.4 True False 4100.355303735262 3138.602363418316 5863.807108435727 7944.091896749448 5310.681570923864 3668.4240225063927 3172.011993847073 2618.5551139733993 3221.6158390461696 2367.7500801468973 1.7317517326325558 1.325563195936454 2.476531268060154 3.3551226387273902 2.2429231933947964 1.5493290669760216 1.339673481776539 1.105925467358 1.3606232625895625 1.0 11.20930109486849 -6.902190950340682 3.1548161288715444 1.2269132323553331 2.253561825768958 0.4867536339066342 0.4997089716967147 0.2568427605758389 5.110784308140683 0.217020762891488 0.18716252944307124 1.2525903156811434e-07 6.902190950340682 1.026648593413625 AHTLLS(ph)PPSANNATFAR ddPTM_A459_Selumetinib_30min_R2 1 AHTLLSPPSANNATFAR 17 0 C9IZD2;C9J8Z7;C9JLE1;F8W8R3;A0A087WWF6;P49005;C9JHC7 C9IZD2 POLD2 DNA polymerase delta subunit 2 1 AHT(0.004)LLS(0.995)PPSANNAT(0.001)FAR 74.89 0.015017 2592100.0 5779.7 9258.7 8100.3 10117.0 8931.3 5961.3 10021.0 8804.4 6949.4 10398.0 True False 5458.487411972271 9968.81251858725 7579.135516939798 8739.047147201547 7809.270247164937 6782.414963706536 10486.996356234791 8830.019346353114 8339.474182459582 10097.782722751515 0.5405629693015324 0.9872278689584318 0.7505742324860186 0.86544218539298 0.7733648526195473 0.6716736881676946 1.0385444650741327 0.8744513116189381 0.8258718187379638 1.0 13.301750919450459 -2.6934942495292145 0.047651074195907 1.3645441941043865 5.767179662208309e-17 0.24496621516541395 0.12848389925011883 705.1304329100008 3.1583841160633166 25.10007765395849 78.62570142173006 0.002025376424551968 2.6934942495292145 -1.3645441941043865 AHTPT(ph)PGIYMGRPTHSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R1 6 AHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGR 33 1 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(0.242)PT(0.747)PGIY(0.011)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.208)PT(0.78)PGIY(0.011)MGRPT(0.001)HSGGGGGGGGGGGGGGGGR;AHT(0.231)PT(0.758)PGIY(0.01)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.186)PT(0.807)PGIY(0.007)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.227)PT(0.723)PGIY(0.049)MGRPT(0.001)HSGGGGGGGGGGGGGGGGR;AHT(0.064)PT(0.793)PGIY(0.142)MGRPT(0.001)HSGGGGGGGGGGGGGGGGR 87.23700000000002 1.3308e-08 75452100.0 8694.58 10235.08 10122.82 11046.94 9552.73 9079.51 9358.86 8660.64 4520.62 6734.23 True False 8897.146797292367 9036.752075440403 8748.196644670066 9117.799305746283 8688.68725817146 8988.178372935487 8652.913655338585 8430.931693476554 7671.161966978617 7598.634017455035 1.1708876591311652 1.1892600768351032 1.1512854316413106 1.1999261031392656 1.1434538416000077 1.182867651250013 1.138745942423564 1.1095325388891772 1.0095448667953972 1.0 12.891524377775431 -8.081995223070022 1.553840998589309 0.9937202139738769 1.172227449631793 0.9320382032306133 0.017566481148735894 0.08338650658607073 0.360583948935103 0.014697923572209675 0.004720636369705378 8.279512705365236e-09 8.081995223070022 0.17850723565791615 AHTPT(ph)PGIYMGRPTHSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R2 4 AHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGR 33 1 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(0.208)PT(0.791)PGIY(0.001)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.244)PT(0.752)PGIY(0.004)MGRPTHSGGGGGGGGGGGGGGGGR;AHT(0.217)PT(0.76)PGIY(0.015)MGRPT(0.007)HSGGGGGGGGGGGGGGGGR;AHT(0.303)PT(0.619)PGIY(0.073)MGRPT(0.004)HS(0.002)GGGGGGGGGGGGGGGGR 88.98899999999998 2.4179e-08 34792200.0 35362.0 32837.4 38327.1 38643.0 37865.6 27000.199999999997 21159.0 26597.8 20456.800000000003 35003.2 True False 33396.721605301886 35355.92299111718 35861.17611339127 33379.7567371068 33108.58480524098 30719.232466587662 22142.935425763106 26675.195194497173 24548.731610749015 33992.56666676436 0.982471312998996 1.0401074840190228 1.0549711195669704 0.9819722371757021 0.9739948480445968 0.9037044118419824 0.6514052217013956 0.784736129401443 0.7221794062038601 1.0 15.052931678693273 -6.944029586385127 3.045233951160059 0.7712024826578057 1.011049152598476 0.5706968785602013 0.0875262896831601 0.16358641677700747 3.0901711096803575 0.03222346191226494 0.02707322539035097 1.1375497874117551e-07 6.944029586385127 0.23984666994067028 AHTPTPGIYMGRPT(ph)HSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R1 1 AHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGR 33 1 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 AHT(0.04)PT(0.098)PGIY(0.216)MGRPT(0.561)HS(0.086)GGGGGGGGGGGGGGGGR 54.363 0.0018484000000000005 21999000.0 281.7 203.96 339.34 486.03 319.87 276.33 402.93 193.18 207.8 196.78 True False 288.2630619072181 180.08026838156846 293.25949186119453 401.1539844130469 290.93781497763524 273.55037108756545 372.5366656991961 188.05623886292477 352.621422888488 222.03862979951708 1.2982563537141998 0.8110312540847796 1.3207588793264673 1.8066855518576046 1.310302694807334 1.2319945017430494 1.677801137737008 0.8469527984059546 1.588108444043618 1.0 7.794666885142591 -5.490520641925384 22.92707481938304 1.3684626444995742 1.0574561522836625 0.13360143063408592 0.2973932141723349 415.2946753802842 294250.8224576057 0.07452252085371158 0.15481293977297075 3.2320595806331875e-06 5.490520641925384 -0.3110064922159117 AHVDEFK ddPTM_A459_Selumetinib_30min_R2 2 AHVDEFK 7 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 ; 102.77 0.026783 2453100.0 35459.0 27414.0 25699.0 35291.0 38835.0 24006.0 30721.0 31795.0 24039.0 30043.0 False True 33488.33073362367 29516.565650096738 24045.55431895557 30484.304919629332 33956.20011069503 27312.60859522906 32149.587372506627 31887.5181860544 28847.47170577979 29175.580528911672 1.1478205446653669 1.0116873465755776 0.8241671248024531 1.0448568414746975 1.1638568794559538 0.9361461914412811 1.1019347958011614 1.0929523117613829 0.9887539916195758 1.0 14.832473742177855 -5.9678822301082 24.999936264604138 1.0541220012553527 0.9859780798384277 0.05524484131029661 0.09486453195542625 487.08173859906054 379133.1219850668 0.026954861250446903 0.03998030656238174 1.0767571638795302e-06 5.9678822301082 -0.06814392141692505 AIAPTPGTLSGY(ph)RS(ph)RAR ddPTM_A459_Selumetinib_30min_R2 1 AIAPTPGTLSGYRSRAR 17 2 A0A494C071 A0A494C071 2 AIAPTPGT(0.006)LS(0.53)GY(0.631)RS(0.833)RAR 87.824 0.033689 0.0 13367.0 12827.0 13315.0 15648.0 14645.0 8969.5 9585.4 9385.7 6511.1 13369.0 True False 12624.115652340664 13810.789654694354 12458.327396275872 13516.715405694358 12805.164172038858 10204.967207985805 10031.140093109765 9413.010833113718 7813.501935334365 12983.002233166468 0.9723571964033874 1.0637593221245247 0.9595875570636306 1.041108609776286 0.9863022390404198 0.7860252216483584 0.7726363989589515 0.7250257424332236 0.6018255096170236 1.0 13.664336415126042 -6.77219913438231 3.6818025239580514 0.7549138923318409 1.0107376218634463 0.5809544656326612 0.09620397463556067 0.1476220120902285 4.294898397585586 0.032961706700462196 0.030536704612320546 1.6896660018173143e-07 6.77219913438231 0.25582372953160537 AICDHVR ddPTM_A459_Selumetinib_30min_R1 2 AICDHVR 7 0 A0A5K1VW95;P40925;P40925-3;B9A041;P40925-2;B8ZZ51 A0A5K1VW95 MDH1 Malate dehydrogenase, cytoplasmic 0 ; 128.86 0.0068086 9675930.0 2971.77 3681.2 4121.1 5106.7 4577.5 4079.9 3829.9 3776.2 1978.22 3250.3 False True 3041.0064589421836 3250.2033926565487 3561.4772555819213 4214.910709631313 4163.465933223262 4038.85991025281 3541.0075595298185 3676.0429091737037 3356.8948565277406 3667.507665603061 0.8291752154912375 0.8862158416571725 0.971089246515943 1.1492575050796083 1.1352303288338592 1.1012546607966494 0.9655078822984705 1.0023272599129631 0.915306841213038 1.0 11.840584265997961 -5.321417712898973 2.8869250096900885 1.042598223158106 0.8476653935877155 0.4986459707860972 0.07149343830210454 0.23385435727449383 3.787139935939645 0.021651499535922818 0.059301981628465596 4.770701975027637e-06 5.321417712898973 -0.19493282957039038 AICDHVR ddPTM_A459_Selumetinib_30min_R2 4 AICDHVR 7 0 A0A5K1VW95;P40925;P40925-3;B9A041;P40925-2;B8ZZ51 A0A5K1VW95 MDH1 Malate dehydrogenase, cytoplasmic 0 ;;; 175.75 8.516799999999998e-07 27508900.0 56840.0 50040.0 49147.0 59007.0 63497.0 43681.8 43196.6 53337.0 44740.0 45703.0 False True 53681.060348548126 53877.90709604002 45984.935527207665 50970.14480724743 55519.939189617646 49698.57144609999 45205.32749243906 53492.20183958432 53689.25014004691 44383.435639345305 1.2094841144059745 1.2139192543327582 1.0360832789258578 1.1484046710900202 1.250915761473859 1.1197549430365163 1.0185179862994913 1.2052289569076131 1.2096686380099004 1.0 15.437733727751363 -6.947802262683318 24.999948146580213 1.1174094754395092 1.1672749855309932 0.11660686886257143 0.08264923257373977 293.11624285801173 140385.8508797058 0.030227444775616237 0.026658099471375096 1.1277107939193854e-07 6.947802262683318 0.04986551009148399 AIDFS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 AIDFSK 6 0 Q13003-2;Q13003 Q13003-2 GRIK3 Glutamate receptor ionotropic, kainate 3 1 AIDFS(1)K 99.511 0.033141000000000004 11422000.0 2712.3 3297.2 2951.5 3015.8 2827.7 2903.4 2671.4 2361.4 1306.9 2343.5 True False 2775.4913127829172 2911.162291173307 2550.7025114289995 2489.147143577283 2571.935034270982 2874.194432076278 2469.8941472435204 2298.768001091784 2217.713847800601 2644.311052623074 1.0496084830979762 1.100915222619338 0.964600026497935 0.9413216123375979 0.9726295368011653 1.0869350749130542 0.934040700239657 0.8693258680031147 0.8386735915960787 1.0 11.368676176969894 -7.481246803278953 6.684681982801484 0.8923184751388431 1.0148502096368472 0.426880415081729 0.0620808869142995 0.20457896978666618 25.703778478950472 0.027904826100283546 0.01826614183001096 3.301818501362112e-08 7.481246803278953 0.12253173449800414 AIDGLNR ddPTM_A459_Selumetinib_30min_R1 1 AIDGLNR 7 0 P52895;B4DK69;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 0 133.47 0.044668 7614100.0 3945.2 4921.1 4027.3 5031.1 4539.2 3875.9 4404.7 3705.0 2821.0 3515.3 False True 4037.115483977126 4344.935324242679 3480.414780375403 4152.512830443553 4128.630161460852 3836.911965035628 4072.4499327556846 3606.731364463899 4787.030962311954 3966.522996921652 1.0177970699048662 1.0954015210840087 0.8774472713448255 1.0468898916421874 1.0408688326438567 0.9673237664355878 1.0267052367819978 0.909292941768652 1.206858239830472 1.0 11.953659198063438 -8.257141424841006 24.9948886781707 1.1034291137067072 0.9999938732320947 0.23003502869080372 0.07727218836064412 484.5202489776473 2817780.080053985 0.052953618732105114 0.01845710345436754 5.531699441114706e-09 8.257141424841006 -0.1034352404746125 AIDS(ph)PGGAVR ddPTM_A459_Selumetinib_30min_R2 2 AIDSPGGAVR 10 0 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 AIDS(1)PGGAVR;AIDS(1)PGGAVR 121.29 0.0035994 3328600.0 32912.0 30689.0 37435.0 35195.0 45128.0 31918.0 33474.0 35658.0 27075.0 37256.0 True False 31082.882797174818 33042.74761931197 35026.47285614623 30401.38028523857 39458.61719056124 36314.414777244085 35030.607327472644 35761.7588765003 32490.756538707414 36180.32247728703 0.8591101645566526 0.9132795220400609 0.9681083654833328 0.8402738893309667 1.090609880974174 1.0037062218016777 0.968222639515274 0.9884311810363356 0.8980228564602811 1.0 15.142917646389462 -6.245120746800534 24.99169771918362 0.9903669268077872 0.9016931282406344 0.42833855744441895 0.05428793309444505 898.7948486068636 1376488.225473266 0.01624638108722219 0.020908213239864356 5.686947947712435e-07 6.245120746800534 -0.08867379856715274 AIEPPPLDAVIEAEHTLR ddPTM_A459_Selumetinib_30min_R1 2 AIEPPPLDAVIEAEHTLR 18 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ; 222.64 1.8128e-14 7542800.0 4289.8 5101.4 4665.1 5166.1 4875.6 4588.6 4918.9 4111.2 2827.6000000000004 3938.6000000000004 False True 4389.743993502254 4504.125716423479 4031.605043560027 4263.937614707409 4434.602840857092 4542.442850115456 4547.86341277089 4002.157620940346 4798.230680267028 4444.157675212814 0.9877561316030592 1.0134936799261502 0.9071696681794641 0.9594478698380622 0.997850023546866 1.0221155913190987 1.0233352966157103 0.9005435705538278 1.0796715667918464 1.0 12.117694287980495 -6.294186886351244 7.985298130220939 1.00088960829203 0.9660225937359587 0.12061139426581968 0.04844818892139623 0.6738689740641826 148.6752771265563 0.01487957322593659 0.017070795561050484 5.079408175548405e-07 6.294186886351244 -0.03486701455607133 AIEPPPLDAVIEAEHTLR ddPTM_A459_Selumetinib_30min_R2 3 AIEPPPLDAVIEAEHTLR 18 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ;; 181.86 1.4271e-09 2754500.0 21387.0 20606.8 25714.100000000002 28485.2 24537.699999999997 19008.0 19941.5 23878.2 19222.699999999997 24087.7 False True 20198.396158944386 22187.275298694585 24059.682801395225 24605.466620289193 21455.054756178746 21626.17946255579 20868.819263332607 23947.681608751187 23067.77712711399 23392.22551363931 0.8634662036396367 0.9484892869965641 1.0285332957040252 1.0518651423714465 0.917187410991269 0.9245028631391318 0.8921262857680907 1.0237453291816123 0.9861300761513203 1.0 14.513741504375865 -5.104410829449505 0.00663231291910859 1.9029442182219725 4.149598210876476e-05 0.07930868135034852 0.057972728791319796 48243.34300621377 55.582823650822725 7632.972523020538 8323.796571443012 7.86301620209848e-06 5.104410829449505 -1.9029027222398638 AIEPQKEEADENYNS(ph)VNTR ddPTM_A459_Selumetinib_30min_R1 1 AIEPQKEEADENYNSVNTR 19 1 C9JFM5;Q12846-2;Q12846 C9JFM5 STX4 Syntaxin-4 1 AIEPQKEEADENYNS(0.992)VNT(0.008)R 131.86 0.00014233 13132000.0 1316.6 1178.3 1399.6 792.67 1498.7 1059.0 1203.2 1167.1 605.0 1131.4 True False 1347.2742183423622 1040.3440882231914 1209.54200745249 654.2450647587387 1363.142849616976 1048.3474214950675 1112.4416552981231 1136.1447167249175 1026.640812548292 1276.6262107692528 1.0553396185799282 0.8149167543695617 0.9474519614661993 0.5124797370128507 1.067769749765353 0.8211858824858123 0.8713918341280198 0.8899587891433893 0.804182777925006 1.0 10.31812045824728 -7.531949466097306 16.53940353409885 0.8843787472993808 0.8621930489657276 0.003133572909952531 0.15260514414019757 42.42760091383516 77256.05875033549 0.06900166823690174 0.04016892743860802 2.93799149268241e-08 7.531949466097306 -0.022185698333653248 AIEPQKEEADENYNS(ph)VNTR ddPTM_A459_Selumetinib_30min_R2 2 AIEPQKEEADENYNSVNTR 19 1 C9JFM5;Q12846-2;Q12846 C9JFM5 STX4 Syntaxin-4 1 AIEPQKEEADENY(0.013)NS(0.98)VNT(0.007)R;AIEPQKEEADENYNS(0.989)VNT(0.011)R 94.564 0.00099296 28019000.0 62787.0 15881.6 41411.0 49327.0 21253.0 25568.0 55445.0 43710.0 29675.0 31730.0 True False 59297.54989627541 17099.6676526073 38746.6613448877 42608.57750617881 18583.00813576933 29089.75991680483 58023.30236218324 43837.188863419935 35610.82918877719 30813.872455559303 1.9243783780112718 0.5549340699475197 1.257442127754936 1.3827725667272162 0.6030727933520951 0.9440475214129272 1.8830253304211015 1.4226445873248568 1.1556752316715857 1.0 14.911292380374134 AIEQADLLQEEDES(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AIEQADLLQEEDESPR 16 0 A0A2R8YGH5;H7C1E4;P61966 A0A2R8YGH5 AP1S1 AP-1 complex subunit sigma-1A 1 AIEQADLLQEEDES(1)PR;AIEQADLLQEEDES(1)PR 226.08 4.9021e-15 11745600.0 3202.6000000000004 3489.3 2290.58 2494.8 3135.3 2578.3 3634.9 3789.7 1660.35 3302.9 True False 3277.214348825191 3080.7711338684376 1979.5318172553068 2059.130013196037 2851.7126685821745 2552.3646429090963 3360.7165665252214 3689.1848453195257 2817.492682833978 3726.8593879704476 0.8793501465076411 0.8266400239870995 0.531152804864288 0.5525107869222259 0.7651784979564642 0.6848567056615058 0.9017556652051157 0.989891074835684 0.7559965079252192 1.0 11.863744672791213 -7.26758629754883 16.245816574329382 0.9110712634334175 0.6997518386730823 0.4166535201436806 0.11883605682483675 4.511795868197409 11917.066193341763 0.051438597645146855 0.03612484252942968 5.400247971524761e-08 7.26758629754883 -0.21131942476033516 AIEQADLLQEEDES(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 AIEQADLLQEEDESPR 16 0 A0A2R8YGH5;H7C1E4;P61966 A0A2R8YGH5 AP1S1 AP-1 complex subunit sigma-1A 1 AIEQADLLQEEDES(1)PR;AIEQADLLQEEDES(1)PR 266.99 2.6837e-50 10509800.0 37432.0 22880.5 38588.0 42828.0 39562.0 35916.0 33739.0 37641.0 34446.0 30457.0 True False 35351.67929216844 24635.36077759681 36105.29009143771 36994.75251757914 34591.867871232556 40863.10298701355 35307.93035256017 37750.529078196974 41336.16250165524 29577.62727321052 1.195216876784017 0.832905241182409 1.2206959590751054 1.2507680949474458 1.1695281555787136 1.381554463769468 1.1937377540942842 1.2763204001961623 1.397548292830603 1.0 14.852218703167267 -5.422092417763561 8.416144609539234 1.2500586709849932 1.014706765035802 0.3060518429597444 0.13325943087117006 0.31848400420191086 24.116644077442295 0.03229889373705403 0.06741086706351232 3.7836206079215197e-06 5.422092417763561 -0.2353519059491913 AIGALAS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 AIGALASSR 9 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 AIGALAS(0.709)S(0.291)R 84.615 0.036262 12324000.0 116210.0 122530.0 120140.0 116940.0 118620.0 110240.0 101930.0 99912.0 91072.0 90414.0 True False 109751.51342548875 131927.65700395222 112410.3231985417 101012.57026724816 103717.89512374511 125424.5593409169 106669.94697046325 100202.72737867796 109288.94476429009 87803.51289621608 1.249967225744319 1.5025327877244612 1.2802485856278998 1.1504388256839473 1.1812499489210626 1.428468579488032 1.2148710621242151 1.1412154716078133 1.244699000750344 1.0 16.421991040683274 -14.52287863198107 0.0850333873501856 0.10717135247800406 1.5125298883328728 0.4186051536245534 0.1038905180940021 235.4638175797221 1.399413953181813 38.47955134375778 3.0903853072610423 3.000000782643712e-15 14.52287863198107 1.4053585358548688 AIGALASS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 AIGALASSR 9 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 AIGALAS(0.051)S(0.949)R 86.882 0.033258 16993000.0 7146.0 8473.0 8851.5 9354.1 8036.8 6954.7 8013.1 6790.5 4946.4 5929.2 True False 7312.487896304507 7480.977221009161 7649.514917809174 7720.582033203879 7309.872859012285 6884.74203236236 7408.665415616179 6610.393881347403 8393.679529237806 6690.270575298797 1.0930033118993727 1.1181875436592563 1.1433790056342432 1.1540014632157187 1.092612440220449 1.0290678014999233 1.1073790412856805 0.9880607677892271 1.2546098748574057 1.0 12.707848843772174 -6.510178829791125 23.482431709664894 1.075248475925329 1.1271184141515163 0.10374127092745755 0.07129535380292275 626.8064434251517 1158983.07214802 0.021374116546668164 0.023098677456253075 3.0890232010082844e-07 6.510178829791125 0.05186993822618735 AIGGIILT(ph)ASHNPGGPNGDFGIK ddPTM_A459_Selumetinib_30min_R2 1 AIGGIILTASHNPGGPNGDFGIK 23 0 A0A3B3ITK7;P36871;P36871-2 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 1 AIGGIILT(0.571)AS(0.429)HNPGGPNGDFGIK 58.294 0.019648 3095500.0 12061.0 10096.0 14299.0 13274.0 16267.0 11541.0 10856.0 10852.0 11604.0 15212.0 True False 11390.697904008428 10870.330736243408 13379.017907574056 11466.058301072784 14223.394031174865 13130.66799123297 11360.825510755907 10883.577523354688 13925.124242849894 14772.790034477406 0.7710593515120909 0.7358346467304915 0.9056527491658312 0.776160649025186 0.9628102746996108 0.8888414416361446 0.7690372288674988 0.7367313485099364 0.9426197901920225 1.0 13.850654703199725 -14.522878745275438 0.20182885763975908 1.7700704851658486 0.8045006251105379 0.31021245733955927 0.07987832266516312 195.02641285693068 1.9273355888173567 60.65118826046167 0.195664543879118 3.0000000000338435e-15 14.522878745275438 -0.9655698600553108 AIGGIILTAS(ph)HNPGGPNGDFGIK ddPTM_A459_Selumetinib_30min_R1 2 AIGGIILTASHNPGGPNGDFGIK 23 0 A0A3B3ITK7;P36871;P36871-2 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 1 AIGGIILT(0.025)AS(0.975)HNPGGPNGDFGIK;AIGGIILT(0.001)AS(0.999)HNPGGPNGDFGIK 164.27 1.5237e-10 1810870000.0 6550.799999999999 8865.9 7133.0 7659.0 6867.5 7122.3 7473.799999999999 6325.3 3758.3999999999996 5553.4 True False 6703.420894362103 7827.876306354914 6164.377778764371 6321.499427236028 6246.335837555598 7050.656128530988 6910.045248809099 6157.532496529961 6377.7302973247915 6266.23298469681 1.0697688564617658 1.2492156492540094 0.9837453847979821 1.0088197235363237 0.996824703583508 1.1251825691368118 1.1027431098850915 0.982652976926917 1.0177933557370555 1.0 12.613382696186864 -5.273359696184584 24.999767759378333 1.031053876025253 1.1594922599271862 0.4264779723903368 0.06122667884029589 640.5240494506373 1343333.5123999857 0.016272685688757678 0.034311439620574063 5.328933538295611e-06 5.273359696184584 0.12843838390193318 AIGGIILTAS(ph)HNPGGPNGDFGIK ddPTM_A459_Selumetinib_30min_R2 7 AIGGIILTASHNPGGPNGDFGIK 23 0 A0A3B3ITK7;P36871;P36871-2 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 1 AIGGIILT(0.045)AS(0.955)HNPGGPNGDFGIK;AIGGIILT(0.008)AS(0.992)HNPGGPNGDFGIK;AIGGIILT(0.021)AS(0.979)HNPGGPNGDFGIK;AIGGIILT(0.245)AS(0.755)HNPGGPNGDFGIK;AIGGIILT(0.019)AS(0.981)HNPGGPNGDFGIK;AIGGIILT(0.002)AS(0.998)HNPGGPNGDFGIK;AIGGIILT(0.047)AS(0.953)HNPGGPNGDFGIK 145.14 1.0535e-07 575956500.0 1485730.0 1414445.0 1538070.0 1508192.0 1727026.0 1304299.9 1063336.1 1295063.8 968757.9 1437711.0 True False 1403159.0744484258 1522928.3833424891 1439112.2507240004 1302773.64782368 1510061.5540716674 1483955.3719693567 1112783.335610509 1298832.221248647 1162536.5493573195 1396200.547808215 1.0049839019552989 1.0907662124421984 1.0307346269009485 0.9330848994929858 1.0815506099336472 1.062852592558355 0.7970082359281262 0.9302619335650463 0.8326429546115662 1.0 20.413074751951967 -7.247165599651208 24.997809666356662 0.8841667729800834 1.0340024996954618 0.5350115166621879 0.06568547297375583 583.8282015167341 1022465.1814741117 0.02432301444826015 0.018750010037499397 5.660234190294543e-08 7.247165599651208 0.14983572671537837 AIGNNSATS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AIGNNSATSPR 11 0 A0A1B0GV57;Q9NYJ8;Q9NYJ8-2 A0A1B0GV57 TAB2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 1 AIGNNS(0.001)AT(0.115)S(0.884)PR 84.605 0.044156 0.0 59447.0 49107.0 64104.0 80687.0 92735.0 56428.0 63488.0 60084.0 68500.0 53900.0 True False 56143.17372519605 52873.34899610785 59979.61843115798 69697.29140716128 81084.80023858119 64200.444797616656 66440.31779908527 60258.83449255832 82201.91404991547 52343.76695098161 1.07258565815052 1.0101173850483893 1.1458789064097568 1.3315299120988127 1.5490822491723744 1.2265155631183073 1.2693071528708406 1.1512131816762239 1.570424118059656 1.0 15.675730132096364 -5.5932702054882775 3.6351354809543106 1.3115992599786077 1.0460915819817505 0.29976468070291606 0.16070230674278416 0.2594008262034911 6.827513023223182 0.04338325109789547 0.08238183488016325 2.5511135795778186e-06 5.5932702054882775 -0.26550767799685726 AIGSGESET(ph)PPSTPTAQEPSSSGGFEFFR ddPTM_A459_Selumetinib_30min_R1 2 AIGSGESETPPSTPTAQEPSSSGGFEFFR 29 0 Q4ADV7-2;Q4ADV7-3;Q4ADV7;H0YFN7 Q4ADV7-2 RIC1 RAB6A-GEF complex partner protein 1 1 AIGS(0.005)GES(0.053)ET(0.929)PPS(0.008)T(0.004)PTAQEPSSSGGFEFFR;AIGS(0.001)GES(0.013)ET(0.985)PPS(0.001)TPTAQEPSSSGGFEFFR 127.93 1.5623e-13 15268200.0 1899.72 2265.05 2646.1 2881.2 2274.4 2241.13 2183.08 1773.23 1059.94 1927.17 True False 1943.9797797883584 1999.8568930068227 2286.77415398688 2378.052506822359 2068.6809215779344 2218.5862669832304 2018.4085179922079 1726.1981801371985 1798.640765045351 2174.5410417254557 0.8939724486624766 0.9196684976890459 1.051612321914315 1.0935882382497693 0.9513184078312344 1.020254952384263 0.9281997806721736 0.7938218442487956 0.8271358095950972 1.0 11.086495222774262 -7.528202974104362 5.86743329598543 0.8575176954214118 0.9902242580332955 0.3148246907256753 0.07512058407255211 0.1696395462159708 22.42183063823558 0.03579298810171616 0.021462086592805567 2.9634460544201325e-08 7.528202974104362 0.13270656261188374 AIGSTSKPQES(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AIGSTSKPQESPK 13 1 F5H8D7;P18887;M0QYS5 F5H8D7 XRCC1 DNA repair protein XRCC1 1 AIGST(0.002)S(0.002)KPQES(0.995)PK 169.98 0.0011376 87839000.0 3247.3 3143.6 3291.1 3260.7 2434.4 2384.1 2430.8 2636.7 1932.4 3084.3 True False 3322.955771854134 2775.5458505800098 2844.186696718272 2691.279955919637 2214.2089498282285 2360.1181185896025 2247.4427989516926 2566.766150791353 3279.1416630881326 3480.1999486261343 0.954817487761278 0.797524823731953 0.8172480715773417 0.7733118773770637 0.6362303840336311 0.6781558971981761 0.6457797920027288 0.7375341039829122 0.9422279499724225 1.0 11.764954480564993 -10.580965352208294 6.159973980972967 1.0000003694739723 0.7657140033193116 0.2865514463146589 0.10500165177246425 5.642308200976597e-07 8.634299007973008e-08 0.1076717149862102 0.026114185445637792 2.624427910549531e-11 10.580965352208294 -0.2342863661546607 AIGSVPERS(ph)PAGVDLSLTGLPPPVSR ddPTM_A459_Selumetinib_30min_R1 1 AIGSVPERSPAGVDLSLTGLPPPVSR 26 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 AIGS(0.056)VPERS(0.872)PAGVDLS(0.019)LT(0.052)GLPPPVS(0.002)R 51.398 0.014586000000000003 14341000.0 871.75 1255.7 1433.2 1412.8 1217.1 897.3 1224.8 947.97 733.0 855.47 True False 892.0600788697809 1108.6820602409082 1238.5793120040796 1166.0810015405484 1107.0135198964572 888.2739766832143 1132.412349907862 922.8267561594714 1243.847463798178 965.277907483448 0.9241484467363897 1.14856255555597 1.283132352249881 1.2080261989840928 1.1468339960069371 0.9202261543507313 1.1731464494615298 0.9560218347536308 1.2885900051737245 1.0 9.914800549800137 -6.562669950471002 24.999943986463446 1.0672323004536395 1.1548856824010907 0.07127547021911729 0.1308688557300615 392.4769822061538 246582.12103001948 0.04250670686146856 0.0425067579808654 2.7373482306952973e-07 6.562669950471002 0.0876533819474512 AILDAEPGPRPALQPS(ph)PSIR ddPTM_A459_Selumetinib_30min_R2 1 AILDAEPGPRPALQPSPSIR 20 1 B5MD46;Q9BXI6;Q9BXI6-2 B5MD46 TBC1D10A TBC1 domain family member 10A 1 AILDAEPGPRPALQPS(0.811)PS(0.189)IR 56.819 0.022212 16414000.0 69587.0 41354.0 68094.0 66893.0 74067.0 49965.0 63029.0 58038.0 44029.0 62536.0 True False 65719.63311883209 44525.71882593202 63712.90617514145 57782.058003138656 64762.04129261882 56847.22521288931 65959.97338959412 58206.880971291845 52836.030273047036 60730.423191958864 1.0821533864683135 0.7331699086830591 1.0491101959516311 0.9514515948703187 1.066385476813107 0.9360584403175423 1.0861108802272874 0.9584468197646093 0.8700092555923914 1.0 15.890131802002925 AILGSYDSELTPAEYS(ph)PQLTR ddPTM_A459_Selumetinib_30min_R1 3 AILGSYDSELTPAEYSPQLTR 21 0 C9J9H5;C9JX80;Q9Y6D9-3;Q9Y6D9 C9J9H5 MAD1L1 Mitotic spindle assembly checkpoint protein MAD1 1 AILGSYDSELTPAEYS(0.734)PQLT(0.266)R;AILGSYDSELTPAEY(0.001)S(0.992)PQLT(0.007)R;AILGSYDSELT(0.005)PAEY(0.215)S(0.717)PQLT(0.063)R 152.4 7.5286e-07 16331300.0 3510.6000000000004 3921.6 4249.4 4416.8 4401.38 3547.51 4294.4 3391.16 2281.67 2859.26 True False 3592.390149561518 3462.457248897622 3672.354820283376 3645.4887936043974 4003.2759561267535 3511.8252702813666 3970.469950558725 3301.2154207598924 3871.827343416629 3226.2738725509075 1.1134796026231755 1.0732062390475152 1.1382650591221404 1.1299377974759566 1.2408357486903294 1.088508108428093 1.2306673603686988 1.023228514121689 1.2000925824549742 1.0 11.65565319612535 -10.934103694087788 5.151651376254205 0.9998735814393462 1.1364503489485955 0.2812100095156338 0.06596537897805632 9.037348008038029e-05 1.0328637301950834e-05 0.06026532462224454 0.014602991610284286 1.1638481106666866e-11 10.934103694087788 0.1365767675092493 AILILDNDGDR ddPTM_A459_Selumetinib_30min_R2 2 AILILDNDGDR 11 0 F8VXB1;F8VUC5;F8W156;F8W651;F8VXR1;F8VYZ4;F8VVA7;P61923-5;P61923;P61923-4 F8VXB1 COPZ1 Coatomer subunit zeta-1 0 ; 159.34 0.008101899999999999 4674800.0 30083.0 28812.0 31131.0 32674.0 35128.0 26264.0 26924.0 29096.0 27371.0 26885.0 False True 28411.10729179055 31021.787754818244 29128.065352869977 28223.744834206154 30714.906591695515 29881.6275991459 28176.019348893864 29180.664542897914 32845.96480963843 26108.76019438109 1.088182934780065 1.1881754447112542 1.11564337548049 1.0810067051854968 1.1764214908337822 1.1445058048208958 1.0791787560620236 1.1176579939317812 1.2580438352912393 1.0 14.672246330731964 -10.532697151604749 5.205862299639353 0.9999990425228523 1.1367364292449016 0.3769405852376576 0.05346191140143781 5.788717277221341e-07 1.1016048998654566e-07 0.05043950800196132 0.012233291924412951 2.9329377701234945e-11 10.532697151604749 0.13673738672204927 AILVDLEPGT(ph)MDSVR ddPTM_A459_Selumetinib_30min_R1 1 AILVDLEPGTMDSVR 15 0 P07437;Q5JP53;A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;Q9BVA1;Q13885 P07437;A0A0B4J269;Q9BVA1 TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 1 AILVDLEPGT(0.939)MDS(0.061)VR 89.26 0.039241000000000005 6258300.0 963.07 1802.7 1949.5 2172.2 2068.9 1755.0 1733.3 1846.4 657.66 1218.0 True False 985.5076571919934 1591.6390459475067 1684.7686078369745 1792.866047244039 1881.7683602939612 1737.3462934125046 1602.5557855121644 1797.427474047543 1116.0009864140663 1374.3421643246868 0.7170759093142167 1.158109739527342 1.2258727495745738 1.3045266992335953 1.3692138749294718 1.264129369316256 1.166052986739016 1.3078456884357823 0.8120255751321127 1.0 10.424525515397201 -8.26296965359107 24.99980126057543 0.9060127722154795 1.2008795505700829 0.29085672010660657 0.17604586522220386 173.98858205660505 2842279.75889983 0.14595558618136714 0.04545051722313 5.457959973572439e-09 8.26296965359107 0.2948667783546034 AILVDLEPGTMDS(ph)VR ddPTM_A459_Selumetinib_30min_R1 1 AILVDLEPGTMDSVR 15 0 P07437;Q5JP53;A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;Q9BVA1;Q13885 P07437;A0A0B4J269;Q9BVA1 TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 1 AILVDLEPGTMDS(1)VR 318.62 6.356899999999996e-110 6165600.0 1045.9 2102.1 1779.7 1914.8 1706.5 1445.8 1712.7 1328.8 654.41 1072.9 True False 1070.26743503287 1855.985154760222 1538.0265151923388 1580.416125247622 1552.1473763070444 1431.256564681368 1583.5096600973197 1293.5559074492926 1110.485973784674 1210.617165930999 0.8840676186924906 1.5330900692564662 1.270448295691853 1.3054631717800211 1.2821124794752097 1.1822536512446453 1.3080185087905605 1.0685094709147887 0.9172891356869854 1.0 10.2415269976442 -7.921441416956421 3.800226687301043 0.964778438654571 1.2639728150826404 0.3840541721533428 0.1523041897641635 0.21437482318136675 5.97350741836423 0.08970023024043736 0.03855430000011793 1.1982807513063434e-08 7.921441416956421 0.29919437642806934 AINGPTSAS(ph)GDDISK ddPTM_A459_Selumetinib_30min_R1 2 AINGPTSASGDDISK 15 0 B4DXZ6;P51114-3;P51114;H7C4S4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 AINGPTS(0.001)AS(0.999)GDDIS(0.001)K;AINGPTS(0.007)AS(0.993)GDDISK 182.91 6.0877e-14 0.0 1823.87 2337.6000000000004 2364.9 2621.1000000000004 2550.7 1971.51 2427.6000000000004 2195.3999999999996 1361.38 2188.9 True False 1866.3626223667661 2063.9127052792433 2043.759569465845 2163.3740891406646 2319.98963536266 1951.6783993878576 2244.4841775280265 2137.170860335774 2310.162428738834 2469.8666366915477 0.755653197885538 0.8356373071397529 0.8274777022793083 0.8759072481899517 0.9393177756635266 0.790195863369442 0.9087471137852905 0.8652980807087508 0.9353389346695085 1.0 11.27021742858615 -1.5228788147049752 0.04349287212607723 1.3161324591672197 0.11104595709872993 0.620657665485292 0.0434870064112452 456.1281623348717 1.5120098771212267 10.901605451726182 39.07118131859658 0.029999995204316312 1.5228788147049752 -1.2050865020684898 AIPGDQHPES(ph)PVHTEPMGIQGR ddPTM_A459_Selumetinib_30min_R1 1 AIPGDQHPESPVHTEPMGIQGR 22 0 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 AIPGDQHPES(1)PVHTEPMGIQGR 98.804 8.389899999999999e-05 14083000.0 1033.5 2366.7 2144.3 1962.5 1856.1 1504.2 2166.6 1570.1 767.55 1333.8 True False 1057.5785391590696 2089.6056637510205 1853.115837796781 1619.786215687518 1688.2160827210714 1489.0691137043252 2003.1716176603338 1528.4558475964286 1302.4762903660192 1505.0062223122065 0.7027070875057684 1.388436561106484 1.231301113791914 1.0762654610151512 1.1217336232187742 0.9894106028456172 1.331005538689916 1.0155810819494124 0.8654291730202738 1.0 10.555553736351653 -7.993614067832688 24.8709647779745 0.9353113794834679 1.1312969344883506 0.14719668795538043 0.18221256775929123 241.1723885215095 939281.879931457 0.0956042407527615 0.045740007546362656 1.0148127900822947e-08 7.993614067832688 0.19598555500488268 AIPGDQHPES(ph)PVHTEPMGIQGR ddPTM_A459_Selumetinib_30min_R2 7 AIPGDQHPESPVHTEPMGIQGR 22 0 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 AIPGDQHPES(0.994)PVHT(0.006)EPMGIQGR;AIPGDQHPES(1)PVHTEPMGIQGR;AIPGDQHPES(0.998)PVHT(0.002)EPMGIQGR;AIPGDQHPES(0.981)PVHT(0.019)EPMGIQGR;AIPGDQHPES(0.999)PVHT(0.001)EPMGIQGR;AIPGDQHPES(1)PVHTEPMGIQGR;AIPGDQHPES(0.999)PVHT(0.001)EPMGIQGR 121.35 1.7358e-05 145500700.0 243134.0 242881.0 255519.0 262384.0 282207.0 203291.0 197459.0 228495.0 194876.0 261908.0 True False 229621.58562251783 261509.1917144942 239079.1857280515 226646.84656235337 246753.63369741014 231292.48995803992 206641.23475758565 229159.88262061618 233856.64529038416 254346.0355212926 0.9027920767544066 1.0281630345781503 0.9399760654340412 0.8910964391398175 0.9701493211469897 0.9093614904749606 0.8124413432828469 0.9009768214037369 0.9194428559151134 1.0 17.956433081598448 -6.930532910490474 7.072438668050611 0.8945531558525474 0.9471404721435108 0.08480847973995875 0.05548234052080988 0.40782830450052376 34.20391527100063 0.01944641387024183 0.01712235010418574 1.1734567555021627e-07 6.930532910490474 0.05258731629096347 AIPTVNHSGTFS(ph)PQAPVPTTVPVVDVR ddPTM_A459_Selumetinib_30min_R1 2 AIPTVNHSGTFSPQAPVPTTVPVVDVR 27 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 AIPT(0.001)VNHS(0.042)GT(0.353)FS(0.604)PQAPVPTTVPVVDVR;AIPTVNHS(0.006)GT(0.077)FS(0.917)PQAPVPTTVPVVDVR 116.45 5.5519e-12 58430000.0 2170.91 2521.43 2280.27 2285.2 2558.49 1895.69 2316.23 2004.92 1232.15 1959.06 True False 2221.487979144476 2226.2198034189955 1970.6218586265288 1886.1327185167481 2327.0750312380974 1876.6210797488052 2141.5149062925298 1951.7430087020148 2090.8685573245925 2210.524433860361 1.0049597032795374 1.007100292273732 0.8914725521423542 0.8532512419339741 1.0527253151299474 0.8489483540661698 0.9687813776175656 0.882932112762752 0.9458699145311835 1.0 11.110172965759926 -5.244729878726039 23.573994411218944 0.9263778945143258 1.0060300426163418 0.19130679404763706 0.06165462850284536 576.1000165241724 812761.5588616935 0.014778219944171661 0.03881069299184535 5.692068544624344e-06 5.244729878726039 0.07965214810201593 AIPTVNHSGTFS(ph)PQAPVPTTVPVVDVR ddPTM_A459_Selumetinib_30min_R2 2 AIPTVNHSGTFSPQAPVPTTVPVVDVR 27 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 AIPTVNHS(0.007)GT(0.004)FS(0.989)PQAPVPTTVPVVDVR;AIPT(0.016)VNHS(0.03)GT(0.093)FS(0.855)PQAPVPT(0.004)T(0.004)VPVVDVR 69.528 0.00049588 25805000.0 35846.0 37773.0 45838.0 45176.0 45246.0 38540.0 38661.0 39139.0 38016.0 46897.0 True False 33853.82282290741 40670.067640661866 42888.83298464088 39022.95086705322 39561.79297562787 43848.535168713155 40458.81310531818 39252.88801018973 45620.26225578953 45542.96175696076 0.7433381913887761 0.8930044527559932 0.9417225259419097 0.8568382327723554 0.8686697449926226 0.9627949847159726 0.88836587574664 0.8618870292112775 1.0016973094380923 1.0 15.474940495642743 -1.5228787452803376 0.120522527716907 1.0218432606825394 0.3950230257979533 0.464188402824368 0.05429438303618728 101.27461832614078 0.8415973401013991 0.38207044512464516 10.6601130326281 0.029999999999999995 1.5228787452803376 -0.6268202348845862 AIPVS(ph)PSAVEEDEDEDGHTVVATAR ddPTM_A459_Selumetinib_30min_R1 4 AIPVSPSAVEEDEDEDGHTVVATAR 25 0 A0A087X0K9;G5E9E7;Q07157-2;H0Y3R8;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 AIPVS(0.81)PS(0.19)AVEEDEDEDGHTVVATAR;AIPVS(0.915)PS(0.085)AVEEDEDEDGHTVVATAR;AIPVS(0.5)PS(0.5)AVEEDEDEDGHTVVATAR;AIPVS(0.5)PS(0.5)AVEEDEDEDGHTVVATAR 259.82 1.7645999999999993e-62 233091800.0 9483.5 12433.24 11773.029999999999 12784.95 12082.18 10116.509999999998 10880.11 9966.39 6151.99 8960.99 True False 9704.447098321278 10977.550480743545 10174.317190624752 10552.298485734593 10989.34895228213 10014.747094456146 10059.414543073182 9702.048961802795 10439.477706428044 10111.220353934214 0.9597701126694699 1.0856800758448755 1.0062402790644343 1.0436226406270297 1.0868469450382654 0.9904587917085073 0.994876403732921 0.95953293689498 1.0324646621281581 1.0 13.303669510550886 AIPVS(ph)PSAVEEDEDEDGHTVVATAR ddPTM_A459_Selumetinib_30min_R2 4 AIPVSPSAVEEDEDEDGHTVVATAR 25 0 A0A087X0K9;G5E9E7;Q07157-2;H0Y3R8;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 AIPVS(0.5)PS(0.5)AVEEDEDEDGHTVVATAR;AIPVS(0.783)PS(0.217)AVEEDEDEDGHTVVATAR;AIPVS(0.5)PS(0.5)AVEEDEDEDGHTVVATAR;AIPVS(0.822)PS(0.178)AVEEDEDEDGHTVVATAR 180.13 9.555e-21 52605400.0 167558.1 139329.3 151187.2 162361.5 170684.2 111112.7 110176.0 131740.5 126410.3 159608.9 True False 158245.89159021937 150015.4092956892 141459.9801521773 140247.58361079052 149241.32485989164 126417.46584433515 115299.4023096022 132123.8430441863 151695.89219889086 155000.5763432751 1.0209374398696232 0.9678377515413529 0.9126416397245527 0.9048197556387688 0.9628436769768608 0.8155935211773806 0.7438643457315416 0.852408721059047 0.9786795364098165 1.0 17.241914054362383 -4.8932199341134215 0.8033941596936883 0.8739319328041774 1.0892609236655455 0.22269131195628067 0.07416899149340733 3.1601660216367593 1.747811132819388 0.03040929267058042 0.5914794889934222 1.2787335677277537e-05 4.8932199341134215 0.21532899086136814 AIPVSPS(ph)AVEEDEDEDGHTVVATAR ddPTM_A459_Selumetinib_30min_R1 6 AIPVSPSAVEEDEDEDGHTVVATAR 25 0 A0A087X0K9;G5E9E7;Q07157-2;H0Y3R8;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 AIPVS(0.194)PS(0.806)AVEEDEDEDGHTVVATAR;AIPVS(0.407)PS(0.593)AVEEDEDEDGHTVVATAR;AIPVS(0.096)PS(0.904)AVEEDEDEDGHTVVATAR;AIPVS(0.05)PS(0.95)AVEEDEDEDGHTVVATAR;AIPVS(0.13)PS(0.87)AVEEDEDEDGHTVVATAR;AIPVS(0.093)PS(0.907)AVEEDEDEDGHTVVATAR 239.14 3.9898000000000004e-45 819179000.0 11526.220000000001 14213.330000000002 15874.76 16986.649999999998 15817.279999999999 12741.92 13932.33 13048.43 6900.29 10600.38 True False 11794.758499880076 12549.22671600215 13719.054785814882 14020.250456411914 14386.609816767603 12613.747853537709 12881.403131116771 12702.343249125965 11709.288152758438 11961.042029445083 0.9860979060891468 1.0491750371839763 1.1469782274857 1.1721596180247151 1.202789002944006 1.0545693111424428 1.0769465653081052 1.0619763075705264 0.9789521785755045 1.0 13.546055460157953 -7.925734859521071 1.4069048559193031 0.988580083254673 1.1083826464687063 0.3313809146374497 0.06059802339678472 0.5464992175516263 1.9497538999424484 0.05866112291408283 0.02051575466727704 1.1864928911091691e-08 7.925734859521071 0.11980256321403338 AIPVSPS(ph)AVEEDEDEDGHTVVATAR ddPTM_A459_Selumetinib_30min_R2 6 AIPVSPSAVEEDEDEDGHTVVATAR 25 0 A0A087X0K9;G5E9E7;Q07157-2;H0Y3R8;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 AIPVS(0.145)PS(0.855)AVEEDEDEDGHTVVATAR;AIPVS(0.147)PS(0.853)AVEEDEDEDGHTVVATAR;AIPVS(0.158)PS(0.842)AVEEDEDEDGHTVVATAR;AIPVS(0.141)PS(0.859)AVEEDEDEDGHTVVATAR;AIPVS(0.303)PS(0.697)AVEEDEDEDGHTVVATAR;AIPVS(0.429)PS(0.571)AVEEDEDEDGHTVVATAR 195.41 3.5578e-28 501915940.0 320848.19999999995 291402.4 310401.7 319550.9 351993.8 274054.3 260465.2 264992.80000000005 251188.5 338002.19999999995 True False 303016.7415011089 313752.02707360365 290430.7925618178 276027.5161639507 307773.1919795024 311802.79220776015 272577.3479020025 265763.8851760802 301433.21879309666 328243.19825081795 0.9231470541228612 0.9558523337134277 0.8848036885745098 0.8409237956334801 0.9376376833384558 0.9499139475527066 0.8304127834317532 0.8096554219320155 0.9183228179575706 1.0 18.324405590805597 -7.255370528554941 24.989619548642274 0.8737357079088303 0.9134569531838702 0.016489433449662028 0.05813862537281684 1246.9442705031631 5134536.710942869 0.022645934120520274 0.01708852021805034 5.554301767397145e-08 7.255370528554941 0.03972124527503995 AIQDGT(ph)IVLMGT(ph)Y(ph)DDGAT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 AIQDGTIVLMGTYDDGATK 19 0 Q92520 Q92520 FAM3C Protein FAM3C 4 AIQDGT(1)IVLMGT(1)Y(1)DDGAT(1)K 51.606 0.028495 4759300.0 686.1 494.53 343.78 476.88 858.99 512.87 601.12 416.55 123.89 290.58 True False 702.0847950817972 436.6301976992402 297.09656424836885 393.6018601462747 781.2945061670023 507.7109934487015 555.7770344355113 405.5017408549092 210.23228143240982 327.8787734888894 2.141293831287277 1.3316818074349543 0.9061171026322519 1.2004493488798915 2.3828761400239817 1.548471674595629 1.6950686637064185 1.2367428868299404 0.6411890565387083 1.0 8.357018696038924 -8.01701243987152 4.009919151864127 0.833649282632936 1.5741390164455555 0.3625700160332571 0.4129179349770015 0.2619700726351544 9.413322146366426 0.30208214348614854 0.11592818829136767 9.61584734488056e-09 8.01701243987152 0.7404897338126195 AIQEGANSIVSSLHQAAAAACLS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 AIQEGANSIVSSLHQAAAAACLSR 24 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 AIQEGANSIVSSLHQAAAAACLS(1)R;AIQEGANSIVSSLHQAAAAACLS(1)R 173.09 1.7814000000000002e-16 8963800.0 1955.88 1906.95 1918.63 2100.2599999999998 2425.29 2044.3899999999999 2821.88 1686.8600000000001 550.97 1038.2 True False 2001.4481985200193 1683.6834074829956 1658.0905842802022 1733.4890177629889 2205.922947719726 2023.8252927576011 2609.023319691379 1642.1189931064991 934.9558487433595 1171.4630829243752 1.7085030059365727 1.437248370883308 1.4154014825128225 1.4797641027112893 1.8830494787876566 1.727604840696675 2.227149414882421 1.4017675990328307 0.7981095284790263 1.0 10.194095774995334 -8.08485144372556 4.67949184013193 0.923618953260154 1.6846540476036518 0.6471427419444243 0.23265011576219274 0.15330530719755225 5.753897869888558 0.18051014947541277 0.06534119884497572 8.225239572250634e-09 8.08485144372556 0.7610350943434978 AIS(ph)ETEENSDELSGER ddPTM_A459_Selumetinib_30min_R1 2 AISETEENSDELSGER 16 0 A7UKX8;F5GWH7;J3KN53;E7EPE2;Q00987-8;Q00987-9;Q00987;Q00987-11 A7UKX8 mdm2;MDM2 E3 ubiquitin-protein ligase Mdm2 1 AIS(0.994)ET(0.005)EENSDELSGER;AIS(0.993)ET(0.007)EENSDELSGER 323.91 9.118099999999997e-118 32754000.0 2507.9 2154.6800000000003 2457.02 2503.4 2579.1 2297.98 2538.8999999999996 2269.92 1378.91 1754.5900000000001 True False 2566.329190476082 1902.4090639164447 2123.370179444784 2066.2281846380306 2345.820860377088 2274.8644075989 2347.3887289198833 2209.714347860702 2339.9095583982908 1979.8087176539025 1.2962510810222179 0.9609054889761384 1.0725127940445698 1.0436504123926358 1.1848724775577888 1.1490324228366073 1.185664406863289 1.1161251731830137 1.1818866830585089 1.0 10.951145333440229 -6.260907961899082 24.994996651812336 1.1451782735043006 1.0823841171613438 0.03766926366836365 0.0941232242769159 120.85549561163859 5684277.830715629 0.0269696178024666 0.03272764544332871 5.483931711363189e-07 6.260907961899082 -0.06279415634295682 AIS(ph)ETEENSDELSGER ddPTM_A459_Selumetinib_30min_R2 2 AISETEENSDELSGER 16 0 A7UKX8;F5GWH7;J3KN53;E7EPE2;Q00987-8;Q00987-9;Q00987;Q00987-11 A7UKX8 mdm2;MDM2 E3 ubiquitin-protein ligase Mdm2 1 AIS(0.499)ET(0.499)EENS(0.001)DELSGER;AIS(0.979)ET(0.021)EENSDELSGER 294.94 3.8263999999999987e-75 56138000.0 26734.0 28649.0 31330.0 36077.0 38444.0 29642.0 28058.0 31425.0 25578.0 35645.0 True False 25248.23130468133 30846.28617894585 29314.261909524797 31163.250363703715 33614.3210262794 33724.916436715 29362.752595872233 31516.44154731121 30694.314709032617 34615.836233167705 0.7293838327236289 0.8911033080688658 0.8468454065956343 0.900259931720042 0.971067715939542 0.9742626527797397 0.8482462303694934 0.9104630994617786 0.8867130784384281 1.0 15.07914458007651 -3.8674016471853325 0.9369983927758717 0.9213849220921506 4.4215630285354823e-14 0.5832528688475567 0.04803719059862019 7.3846111299645925 1.436682148274734 0.016113297719037724 10.388142468881636 0.00013570578225864964 3.8674016471853325 -0.9213849220921064 AIS(ph)PTSATSSGR ddPTM_A459_Selumetinib_30min_R1 1 AISPTSATSSGR 12 0 A0A087WY00;G3V394;F8WE88;F8W6H6;Q9Y4I1-2;Q9Y4I1;Q9Y4I1-3 A0A087WY00 MYO5A Unconventional myosin-Va 1 AIS(0.86)PT(0.107)S(0.032)AT(0.001)SSGR 119.21 0.0043318 19305000.0 2781.6 3668.3 3434.1 3490.5 3338.3 3118.6 3855.8 2997.6 1738.9 2758.2 True False 2846.4058679485915 3238.813730653597 2967.768082161045 2880.94969979989 3036.3513544247344 3087.2297154622433 3564.953901677609 2918.0939104229396 2950.786295768967 3112.241837143143 0.9145837685163395 1.0406690418462594 0.9535788789746762 0.9256831090107168 0.9756154930466227 0.9919633103756939 1.1454617244494179 0.9376179818665956 0.9481224307676608 1.0 11.603738454141466 -6.794503376701737 4.192286745918662 1.0105108296734888 0.9634096090532533 0.10863469171169926 0.06136781964338202 0.513667447400247 19.782041942252146 0.022716429531845782 0.02070928675982299 1.605079778323438e-07 6.794503376701737 -0.04710122062023547 AIS(ph)PTSATSSGR ddPTM_A459_Selumetinib_30min_R2 3 AISPTSATSSGR 12 0 A0A087WY00;G3V394;F8WE88;F8W6H6;Q9Y4I1-2;Q9Y4I1;Q9Y4I1-3 A0A087WY00 MYO5A Unconventional myosin-Va 1 AIS(0.931)PT(0.034)S(0.034)ATSSGR;AIS(0.779)PT(0.11)S(0.11)ATSSGR;AIS(0.863)PT(0.105)S(0.032)ATSSGR 115.92 0.0051383 51870000.0 87077.0 70174.0 90412.0 92670.0 102395.0 66878.0 68246.0 93186.0 65771.0 87583.0 True False 82237.60893684959 75556.12015502632 84594.99035314242 80048.1861353334 89531.22467708566 76089.83744196156 71419.57422688344 93457.15583222719 78927.03779528434 85054.2512220373 0.9668841681077791 0.8883285558270831 0.9946003772616143 0.9411426822906783 1.05263668059767 0.8946035777015565 0.8396943503792653 1.0987946456462687 0.9279611149505315 1.0 16.37609572670997 -7.7687708997972775 24.999995604802994 1.010033352549969 0.9424993469782043 0.17876741236895677 0.06778913892584473 315.8644922143703 1077055.6086401462 0.03580437436759037 0.01774369543325665 1.7030566725470222e-08 7.7687708997972775 -0.0675340055717647 AIS(ph)PTSSSR ddPTM_A459_Selumetinib_30min_R2 2 AISPTSSSR 9 0 A0A0U1RRL2;B1AM27;O14795;O14795-2 A0A0U1RRL2 UNC13B Protein unc-13 homolog B 1 AIS(0.975)PT(0.02)S(0.006)SSR;AIS(0.575)PT(0.419)S(0.003)S(0.003)SR 99.788 0.018495 31542000.0 102156.0 90415.0 133311.0 137617.0 131027.0 90129.0 88358.0 117024.0 87917.0 106676.0 True False 96478.57848286926 97349.5397699533 124733.91539804236 118873.32719743373 114566.21686375786 102543.45164039833 92466.82207805551 117364.52046563379 105502.85660622468 103595.98670246612 0.9312964869957898 0.9397037749111558 1.2040419650259777 1.1474703893582774 1.1058943546992692 0.9898400015717719 0.8925714694298512 1.1329060536168425 1.018406793201702 1.0 16.660608588691012 -6.771002066247602 24.98609184856377 1.0079156496780404 1.0709131707308555 0.08584441524886088 0.09536405481664659 573.3143733077472 1497990.5565804977 0.03653184046626756 0.032623647674890295 1.694329739297037e-07 6.771002066247602 0.06299752105281509 AIS(ph)SANLLVR ddPTM_A459_Selumetinib_30min_R1 2 AISSANLLVR 10 0 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 AIS(0.846)S(0.154)ANLLVR;AIS(0.5)S(0.5)ANLLVR 145.81 0.0008868999999999998 31144800.0 4251.9 5099.9 2974.3999999999996 3586.6 4001.7999999999997 2975.6000000000004 4359.6 4716.0 1982.27 3869.3 True False 4350.960997242815 4502.801337120813 2570.4928172096957 2960.267638820309 3639.8378965751717 2945.668165628632 4030.751862065906 4590.916360273077 3363.7674107274424 4365.962345173654 0.9965640226037629 1.031342229073145 0.5887574408540749 0.6780332501247364 0.833685132579951 0.6746893199582712 0.9232218565791558 1.0515244973077007 0.7704526848349742 1.0 12.092083972328057 -10.549165195519675 6.951754350673947 1.0000000271276948 0.8360607367025457 0.09060687743994589 0.15310135850419893 7.065876167318894e-08 1.0009782349945478e-08 0.1582985186831844 0.03839302387805168 2.8238056606120762e-11 10.549165195519675 -0.1639392904251491 AIS(ph)SANLLVR ddPTM_A459_Selumetinib_30min_R2 4 AISSANLLVR 10 0 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 AIS(0.908)S(0.092)ANLLVR;AIS(0.5)S(0.5)ANLLVR;AIS(0.905)S(0.095)ANLLVR;AIS(0.5)S(0.5)ANLLVR 152.96 0.00061384 45267200.0 57277.8 42783.0 64784.4 58441.5 57854.6 67757.2 32340.3 52558.6 50707.1 71124.3 True False 54094.52917720044 46064.31853097284 60616.24223592143 50481.666882789286 50586.387921313675 77090.13926137854 33844.18803108873 52711.53682445534 60849.9368747513 69070.75665587561 0.7831755694629242 0.6669149255230333 0.8775963254308004 0.7308688847046964 0.7323850261746114 1.1161038765719205 0.48999301107568977 0.7631527346236383 0.8809797347076697 1.0 16.075787407711815 -8.516456531666995 3.264915344100605 0.9986792434318762 0.7705891636612046 0.19257717002610775 0.1495888126107678 0.3612927877782825 9.735808812425537 0.14004033896516874 0.037142248837257585 3.0446927166523544e-09 8.516456531666995 -0.22809007977067164 AIS(ph)SDMFFGR ddPTM_A459_Selumetinib_30min_R1 2 AISSDMFFGR 10 0 Q8N6H7;E9PMU9;H0YDN9;A0A0D9SF70;G5E9L0;Q8N6H7-3;Q8N6H7-2 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 AIS(0.963)S(0.037)DMFFGR;AIS(0.995)S(0.005)DMFFGR 115.0 0.006782300000000001 4419200.0 1628.18 1797.4499999999998 1736.8899999999999 2215.1 1700.73 1523.98 1873.27 1772.25 960.9300000000001 1718.88 True False 1666.1134261132213 1587.0037183881645 1501.0298780538408 1828.2743675767756 1546.8992717882686 1508.6501448631284 1731.9677357216697 1725.2441729206882 1630.628026449638 1939.514991309045 0.8590361165441183 0.8182477194038297 0.7739202247881283 0.9426451333293437 0.7975701547654517 0.7778491796265461 0.8929901256152217 0.8895235049233943 0.840740099332293 1.0 10.921480211757824 -10.522954487165709 0.33372880194754817 1.0793471452106842 0.8277187962613859 0.47001350043720413 0.05072856189793308 12.926942681304043 1.1279280297123877 1.0221041985229105 0.0463757037507042 2.9994768392129904e-11 10.522954487165709 -0.2516283489492983 AIS(ph)SPTVSR ddPTM_A459_Selumetinib_30min_R1 1 AISSPTVSR 9 0 O94811 O94811 TPPP Tubulin polymerization-promoting protein 1 AIS(0.72)S(0.27)PT(0.01)VSR 94.409 0.023293 27788000.0 1363.4 1649.2 1680.3 1551.6 1642.6 1231.0 1535.3 1554.7 785.69 1399.1 True False 1395.1645672854138 1456.1108973077203 1452.1244892272225 1280.642187139237 1494.0271200245838 1218.617257658572 1419.4910849228777 1513.4643056226798 1333.2585454728396 1578.6881133880704 0.8837493330403362 0.922355014241994 0.9198298745093951 0.8112065811345168 0.9463725655210052 0.7719176747605077 0.8991586576758754 0.9586848046727787 0.8445357472233658 1.0 10.624510464275472 -10.861520310402936 5.298964778503494 1.000035870823541 0.8853810567898629 0.27437379843942267 0.056465754387388975 2.317882080388963e-05 2.8928338026195983e-06 0.05295937252045066 0.01284051842277545 1.375560478716781e-11 10.861520310402936 -0.11465481403367817 AIS(ph)SPTVSR ddPTM_A459_Selumetinib_30min_R2 1 AISSPTVSR 9 0 O94811 O94811 TPPP Tubulin polymerization-promoting protein 1 AIS(0.436)S(0.436)PT(0.127)VSR 86.882 0.033258 64902000.0 312900.0 220670.0 262740.0 279220.0 247530.0 201350.0 175680.0 202770.0 166370.0 147430.0 True False 295510.2706379434 237594.6794341153 245835.5944496826 241189.75431863338 216433.06845372304 229084.13482668388 183849.46810331606 203360.0271296196 199648.6487661962 143173.31283085753 2.0640038621377306 1.6594899896938582 1.7170490057746204 1.6845999407974221 1.5116858314888146 1.6000477344358157 1.2841043101413225 1.4203766268219664 1.3944543491988457 1.0 17.12740307713225 -1.5228787453555879 0.09736384947833247 0.6947142075248458 4.249762671456945 0.8659316147663838 0.09944857780028903 45.45535873096851 0.3160894103852291 1.3636038769437024 21.570250994550033 0.029999999994801893 1.5228787453555879 3.555048463932099 up AIS(ph)TGSLASSTLNK ddPTM_A459_Selumetinib_30min_R1 2 AISTGSLASSTLNK 14 0 Q12923-3;Q12923;Q12923-4 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 AIS(0.871)T(0.086)GS(0.043)LASSTLNK;AIS(0.5)T(0.5)GS(0.001)LASSTLNK 185.66 7.9994e-05 32278000.0 3998.8 3680.5 4878.7 5171.6 4942.7 4240.1 4238.0 3880.8999999999996 1814.97 3503.0 True False 4091.964259689682 3249.5853489819688 4216.19933678084 4268.477142955192 4495.633657704562 4197.448443702771 3918.3242479666255 3777.9659250601735 3079.8715298359903 3952.6441721095043 1.0352473133208506 0.822129492938314 1.0666781914069128 1.0799042253978377 1.137373733114273 1.0619343054759762 0.9913172239522481 0.9558072420781287 0.7791927114431553 1.0 11.948602370292932 -7.847187100963183 2.8173429240519763 0.8857435121436937 1.0308029883679197 0.26366657418274264 0.0927011849478313 0.36629674315171934 5.736470890045773 0.06427196184839036 0.026955049678117127 1.4217161572571744e-08 7.847187100963183 0.145059476224226 AIS(ph)TGSLASSTLNK ddPTM_A459_Selumetinib_30min_R2 2 AISTGSLASSTLNK 14 0 Q12923-3;Q12923;Q12923-4 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 AIS(0.969)T(0.025)GS(0.005)LASSTLNK;AIS(0.855)T(0.145)GS(0.001)LASSTLNK 145.52 0.00051542 26931000.0 66357.0 53154.0 76574.0 84459.0 86222.0 63103.0 67470.0 70618.0 67164.0 63230.0 True False 62669.14358811766 57230.74088295187 71647.31220746745 72955.53850009853 75390.02152554007 71794.86545799972 70607.4886892687 70823.4866885607 80598.6767189564 61404.38560873037 1.0205971929667426 0.9320301850689782 1.166810993989992 1.1881160893779195 1.2277628182118192 1.1692139697558028 1.1498769670814823 1.1533945985527643 1.312588277204373 1.0 15.906054078630492 -5.272480175661814 22.291441836614815 1.1782734592147683 0.9763137065088177 0.5096104580240757 0.07611097946211703 104.72767501640669 211448.00032334198 0.01859909985286866 0.03948181715809668 5.3397364743341425e-06 5.272480175661814 -0.20195975270595068 AIS(ph)TPEK ddPTM_A459_Selumetinib_30min_R1 1 AISTPEK 7 0 P42695 P42695 NCAPD3 Condensin-2 complex subunit D3 1 AIS(0.5)T(0.5)PEK 126.24 0.005767100000000001 8240300.0 7767.0 9693.3 9757.3 10175.0 8155.5 9355.6 7683.4 8178.1 4923.5 6581.4 True False 7947.955988048858 8558.403929707089 8432.31225301242 8398.127258405344 7417.836464970471 9261.49115820515 7103.834952059173 7961.190221787374 8354.819901787629 7426.186798264772 1.070260714409447 1.1524627863800672 1.1354834563254916 1.1308801524313499 0.9988755557163937 1.2471395360495405 0.9565925481054529 1.0720428179436063 1.125048443938933 1.0 12.858405889854847 -12.481298912028254 0.11903473152564983 0.7991137654319377 1.1592011014656245 0.14141550467328778 0.07666922183199756 161.49957373700195 2.063508292953564 9.190474591624314 0.8464233692610628 3.3014223569987947e-13 12.481298912028254 0.3600873360336868 AIS(ph)TPETPLTK ddPTM_A459_Selumetinib_30min_R2 1 AISTPETPLTK 11 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 AIS(0.639)T(0.361)PETPLTK 161.93 0.00061866 10781000.0 94734.0 88659.0 106050.0 110930.0 109340.0 84068.0 86553.0 87182.0 85635.0 104000.0 True False 89469.06353024913 95458.86021638311 99226.85845850967 95821.14263507618 95603.73168799776 95647.60390667827 90577.88600151574 87435.68518624284 102764.3928418176 100997.24977554903 0.8858564340027125 0.9451629666008318 0.9824708957820754 0.9487500189165946 0.9465973766658247 0.9470317668970241 0.8968351732627499 0.8657234269304888 1.0174969424434404 1.0 16.623956482372314 -8.293094823168435 24.976153667862068 1.0087485244605239 0.930737740473496 0.4827746454279901 0.03357011052975634 727.1848765845804 573742.5340955136 0.03471422638828233 0.008966093342838792 5.092196767019938e-09 8.293094823168435 -0.07801078398702788 AISAPTS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 AISAPTSPTR 10 0 B0QY95;Q9NQG6;Q9NQG6-2 B0QY95 MIEF1 Mitochondrial dynamics protein MID51 1 AIS(0.001)APT(0.237)S(0.673)PT(0.089)R;AIS(0.001)APT(0.386)S(0.612)PT(0.001)R 112.85 0.0079896 31534000.0 282050.0 216153.0 322210.0 352340.0 353980.0 237410.0 243810.0 278030.0 247870.0 288160.0 True False 266374.790135609 232731.2400585599 301479.35939572233 304350.6841795975 309509.86777864886 270111.0725065953 255147.6481003495 278839.0212696559 297450.92606646026 279840.0720704051 0.9518822238889061 0.8316580192989905 1.0773273361646112 1.0875879280899619 1.1060241140188782 0.9652337154867437 0.9117623727460904 0.996422775361145 1.0629318519887474 1.0 18.09424304036277 -5.263375982960199 24.97234543583072 1.0246036142159092 0.8917701202861136 0.4200575927270648 0.06303136755529644 166.32725698060398 2144810.8118430437 0.018076034606238984 0.04091632156213865 5.452855850941362e-06 5.263375982960199 -0.1328334939297956 AISPT(ph)SSSR ddPTM_A459_Selumetinib_30min_R1 2 AISPTSSSR 9 0 A0A0U1RRL2;B1AM27;O14795;O14795-2 A0A0U1RRL2 UNC13B Protein unc-13 homolog B 1 AIS(0.112)PT(0.869)S(0.018)SSR;AIS(0.2)PT(0.799)SSSR 156.16 0.0019548 28726000.0 7507.299999999999 8757.5 8566.6 9231.8 10046.4 7425.799999999999 8122.5 8372.599999999999 3900.1 6143.4 True False 7682.205483337093 7732.1678287487 7403.302772965492 7619.639432348546 9137.70489383598 7351.10319408694 7509.813285537735 8150.531449962337 6618.184847966275 6931.965231783478 1.1082290846055773 1.1154366143234886 1.067994793023615 1.0992033539654873 1.318198315816567 1.0604645217176925 1.0833599180654845 1.1757894301880887 0.9547342819351573 1.0 12.759048703144684 -8.267393420501286 24.95459178475665 0.9773671197463865 1.1276895209481745 0.4175828973008703 0.07142813137243169 506.96284905440405 2124748.928630378 0.06382835480481697 0.018198739421913097 5.402646839699115e-09 8.267393420501286 0.15032240120178808 AISPT(ph)SSSR ddPTM_A459_Selumetinib_30min_R2 1 AISPTSSSR 9 0 A0A0U1RRL2;B1AM27;O14795;O14795-2 A0A0U1RRL2 UNC13B Protein unc-13 homolog B 1 AIS(0.262)PT(0.736)S(0.001)SSR 121.5 0.014597 19695000.0 61577.0 58078.0 82310.0 73023.0 94330.0 50372.0 54989.0 62918.0 50295.0 65112.0 True False 58154.796852261636 62532.39584979638 77014.2642123521 63077.1414282988 82479.42207910038 57310.285768511145 57546.09745863639 63101.08096336441 60355.40535971523 63232.0473787071 0.9197044736502523 0.9889351751538205 1.2179625269936467 0.9975501987231167 1.3043927169575513 0.906348728917007 0.9100780354933531 0.9979287968558362 0.9545065811049389 1.0 15.948368312572155 AISS(ph)ANLLVR ddPTM_A459_Selumetinib_30min_R1 1 AISSANLLVR 10 0 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 AIS(0.23)S(0.77)ANLLVR 171.49 0.00017303 9047300.0 2623.2 2897.4 1999.8 1793.1 2445.9 2280.3 2565.9 2806.6 1248.6 2288.1 True False 2684.3154561413357 2558.171061035283 1728.238144115098 1479.9687456556885 2224.668776858718 2257.3622523467434 2372.352097182058 2732.1598508783754 2118.7830058641293 2581.799922981374 1.0397070014014023 0.9908479112824493 0.6693927475679013 0.5732313850047185 0.861673577823082 0.8743366332353202 0.9188752683990118 1.0582384121087782 0.8206611933807137 1.0 11.334161487744536 -7.077596709517011 2.2010736983068524 0.9561848433195036 0.8143608119757052 0.14644786404724086 0.13944768538264274 0.6508521883784794 6.232027061192639 0.06865975341173053 0.05108077754986713 8.363793284859244e-08 7.077596709517011 -0.1418240313437984 AISS(ph)DMFFGR ddPTM_A459_Selumetinib_30min_R1 1 AISSDMFFGR 10 0 Q8N6H7;E9PMU9;H0YDN9;A0A0D9SF70;G5E9L0;Q8N6H7-3;Q8N6H7-2 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 AIS(0.24)S(0.76)DMFFGR 152.64 0.00062605 6821700.0 1380.8 1380.8 1886.7 1851.3 1628.4 1559.9 1695.4 1557.8 608.92 1257.6 True False 1412.969953430907 1219.1352940834947 1630.4965029012674 1528.0052082049951 1481.1115075173698 1544.2088222758791 1567.5146130256298 1516.4820835524604 1033.2927662428203 1419.0252100613516 0.995732805458627 0.859135754206076 1.1490257476333157 1.0767991980487308 1.0437527797362627 1.0882180325810529 1.1046418357555876 1.068678747072362 0.7281708308749116 1.0 10.470684504862113 -8.235647689327772 24.925539306779466 0.8640853815810464 1.0493176143491907 0.37182437588393236 0.09574069954369199 654.6228169388985 632640.9370870341 0.06458194752080809 0.02439159513025996 5.8123573945958545e-09 8.235647689327772 0.18523223276814427 AISS(ph)PTVSR ddPTM_A459_Selumetinib_30min_R1 1 AISSPTVSR 9 0 O94811 O94811 TPPP Tubulin polymerization-promoting protein 1 AIS(0.04)S(0.943)PT(0.017)VSR 99.53 0.018725 26963000.0 1986.9 2280.8 2672.9 2886.6 2424.3 2000.4 2538.0 2320.3 1151.2 2124.8 True False 2033.1909041656074 2013.7628756848467 2309.934861188741 2382.5094981929124 2205.0224930449294 1980.2777922178768 2346.5566166444773 2258.7581066033986 1953.502319678669 2397.538777304674 0.8480325421269438 0.8399292202267233 0.9634608970894651 0.993731371832635 0.9197025357495271 0.8259627793983444 0.9787356262418783 0.9421153592947125 0.81479487972028 1.0 11.22733843395043 -5.247017667398286 23.999622645751963 0.9277056429711196 0.8439808513740036 0.24168307600078587 0.060723424526834796 700.714703559532 1166071.9159139267 0.015592531492750614 0.0407946432114415 5.66216254502979e-06 5.247017667398286 -0.08372479159711599 AISS(ph)PTVSR ddPTM_A459_Selumetinib_30min_R2 1 AISSPTVSR 9 0 O94811 O94811 TPPP Tubulin polymerization-promoting protein 1 AIS(0.08)S(0.755)PT(0.165)VSR 106.4 0.01319 48715000.0 286760.0 219500.0 271480.0 237240.0 239540.0 184190.0 143760.0 167400.0 138340.0 172290.0 True False 270823.0271912328 236334.9441962592 254013.27236507458 204927.50273817306 209446.84368522937 209560.50058965446 150445.12485503592 167887.10628543835 166011.86554255907 167315.54003682014 1.6186364227234025 1.4125104227870906 1.5181690374317616 1.2247965890859622 1.2518074749012413 1.2524867716623198 0.899170064071325 1.0034160978023465 0.9922082880408228 1.0 17.35221192156368 -6.240778633450482 0.5906748762317663 0.9497020942659379 1.606311906309338 0.8585887452526613 0.08714425593232114 0.3606667961909253 0.25838167812855106 0.06273256011648559 0.12894953278193844 5.744091727550482e-07 6.240778633450482 0.6566098120434002 AIST(ph)PETPLTK ddPTM_A459_Selumetinib_30min_R1 3 AISTPETPLTK 11 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 AIS(0.232)T(0.762)PET(0.005)PLTK;AIS(0.008)T(0.992)PETPLTK;AIS(0.024)T(0.976)PETPLTK 193.22 4.7413e-05 43909300.0 16804.6 17220.9 16715.1 17798.0 16388.6 14021.6 15698.599999999999 15366.6 7900.0 13107.3 True False 17196.114483940502 15204.669022220784 14445.28122947208 14689.913409837689 14906.25402364234 13880.555434594171 14514.441962984627 14959.027850248573 13405.72300682894 14789.749630913757 1.162704907999046 1.028054524360558 0.9767089768225918 0.9932496341339417 1.0078773742379696 0.9385253828489987 0.9813852381007399 1.0114456446903597 0.9064198746683375 1.0 13.852310009451173 -4.654050219439903 1.8105817847259436 0.9770340700661533 1.2715616797157439 0.7686497367115881 0.030768197062197897 0.5710066055423192 1.4771768542412644 0.00805760932208838 0.32099735265957496 2.217939934521124e-05 4.654050219439903 0.29452760964959057 AIST(ph)PETPLTK ddPTM_A459_Selumetinib_30min_R2 3 AISTPETPLTK 11 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 AIS(0.013)T(0.984)PET(0.003)PLTK;AIS(0.066)T(0.934)PETPLTK;AIS(0.001)T(0.997)PET(0.002)PLTK 199.8 4.5089e-05 48305000.0 244457.0 242846.0 272994.0 299618.0 317910.0 216326.0 238723.0 247978.0 226085.0 244617.0 True False 230871.0585789064 261471.5073270366 255429.86325339353 258809.51153012048 277971.3036485399 246122.94288809173 249824.09252065077 248699.57492503224 271308.31734270224 237554.2716187059 0.9718665844471674 1.1006811434934742 1.0752484538075553 1.0894753008084441 1.1701380983571898 1.036070373355101 1.0516506010114561 1.0469168717968391 1.1420898285431564 1.0 17.85789762346179 -4.755273593521781 24.98527547473032 1.0814472429999396 0.9718664026165692 0.3114700225394256 0.04773815242701946 246.18173775622512 997491.4374285334 0.011600083472482066 0.10395108835989 1.7568165194185793e-05 4.755273593521781 -0.10958084038337035 AISTPET(ph)PLTK ddPTM_A459_Selumetinib_30min_R2 1 AISTPETPLTK 11 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 AIS(0.002)T(0.18)PET(0.607)PLT(0.212)K 101.39 0.025064 0.0 40369.0 37909.0 43299.0 47611.0 37180.0 43881.0 37809.0 36896.0 26274.0 38013.0 True False 38125.452589910965 40816.498403352954 40513.18948038667 41126.29966644389 32509.116006582743 49925.20943794244 39567.1934171122 37003.36125153837 31529.534156897458 36915.4659203648 1.0327772287137427 1.1056747459561689 1.097458435653582 1.1140669267228764 0.8806367519974536 1.3524198650409198 1.0718324266167407 1.0023809893491034 0.8541009403731747 1.0 15.171937746837038 -7.908462731633583 3.399999865497346 0.9269614847553321 1.0967280827718617 0.26147419535429983 0.11319725384785563 0.3154888864084188 7.0647639445672565 0.07146759584630609 0.030032645824258145 1.2346312587593329e-08 7.908462731633583 0.1697665980165296 AIT(ph)PPLPESTVPFSNGVLK ddPTM_A459_Selumetinib_30min_R2 2 AITPPLPESTVPFSNGVLK 19 0 Q92667-2;Q92667;I3NI36 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 AIT(0.989)PPLPES(0.009)T(0.003)VPFSNGVLK;AIT(0.888)PPLPES(0.054)T(0.054)VPFS(0.004)NGVLK 106.87 0.0018808 19342200.0 109540.0 61994.0 85069.0 102422.0 73154.0 60769.0 117167.0 86885.0 81670.0 71697.0 True False 103452.20532336332 66748.74045787184 79595.75315612405 88471.94691219495 63963.74051494232 69139.37814394222 122615.49766200605 87137.82096541388 98006.28205046113 69626.92131882225 1.485807549204349 0.9586628159563283 1.1431749623346756 1.2706571716287896 0.9186639205552666 0.992997777789893 1.7610357508204142 1.251496106892463 1.4075917790719132 1.0 16.08735761297364 AIT(ph)PPQQPYK ddPTM_A459_Selumetinib_30min_R1 1 AITPPQQPYK 10 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 AIT(1)PPQQPYK 104.79 0.030176 32859000.0 2960.5 3231.5 3739.6 3909.8 3702.3 2765.1 2983.8 3227.0 1829.5 2432.9 True False 3029.4738898697888 2853.154477716407 3231.7828601524257 3227.0268260356984 3367.4276186941547 2737.2856045099234 2758.729563728837 3141.409477226723 3104.527878606779 2745.186413452816 1.1035585325003137 1.0393299572424273 1.1772544277193848 1.1755219282091804 1.226666284734632 0.9971219408255212 1.0049334173481455 1.1443337551986312 1.130898748220888 1.0 11.422688404250499 -6.7703508835208295 24.99999674025273 1.0613206879199608 1.1421722108575227 0.3066097543961285 0.06659075995125993 302.9985136531031 850015.8242210824 0.025523563925818185 0.02283427971529907 1.6968721290325138e-07 6.7703508835208295 0.08085152293756193 AIT(ph)PPQQPYK ddPTM_A459_Selumetinib_30min_R2 3 AITPPQQPYK 10 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 AIT(1)PPQQPYK;AIT(1)PPQQPYK;AIT(1)PPQQPYK 112.13 0.019713 153346000.0 242163.0 224806.0 275676.0 273491.0 282182.0 190316.0 225952.0 224220.0 179110.0 243939.0 True False 228704.5499152965 242047.89733477958 257939.30629333435 236241.05400171044 246731.7744209129 216530.30148336315 236459.2157153938 224872.44307838098 214937.00475153787 236895.84724036144 0.9654223684353832 1.021748165510013 1.0888300039790126 0.9972359446301875 1.0415200489798861 0.914031647265075 0.9981568628996497 0.9492460323722721 0.9073059205358569 1.0 17.853893382942147 -6.749928053262202 24.96700147186815 0.9533515152433607 1.0251157700051383 0.41930808317091484 0.04067830376394196 210.37833414164083 456290.7139290969 0.013376590145232334 0.013266799158005105 1.7785740304082144e-07 6.749928053262202 0.07176425476177761 AITIAGVPQSVTECVK ddPTM_A459_Selumetinib_30min_R2 1 AITIAGVPQSVTECVK 16 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 166.62 0.00014217 0.0 18214.0 18968.0 20115.0 25863.0 21708.0 13868.0 18703.0 20386.0 17215.0 16057.0 False True 17201.738796419002 20422.784608267135 18820.822799556063 22340.414783836495 18980.8469680177 15778.191118830153 19572.726559291415 20445.319884916025 20658.481027288944 15593.392688903738 1.1031427951314126 1.3097075803651115 1.206974208566489 1.4326846780260938 1.2172365146376694 1.0118510726698955 1.2551935906301759 1.3111527614811445 1.324822727127851 1.0 13.92864723208495 -6.507746228262362 24.54595475529407 1.1946941393510095 1.2702581678804916 0.07773185015874962 0.12859419630002655 1671.913388055377 2711961.6145573854 0.041319428169597175 0.04532590249414241 3.106374208717392e-07 6.507746228262362 0.07556402852948207 AITS(ph)PLAAGSK ddPTM_A459_Selumetinib_30min_R2 2 AITSPLAAGSK 11 0 Q9UGU5;B0QXZ8;B0QXZ9 Q9UGU5 HMGXB4 HMG domain-containing protein 4 1 AIT(0.053)S(0.947)PLAAGSK;AIT(0.046)S(0.954)PLAAGSK 101.35 0.013563999999999998 0.0 57021.0 57580.0 62419.0 59575.0 69802.0 61473.0 60227.0 63843.0 54866.0 59726.0 True False 53852.00109314857 61996.200851118796 58403.02949666867 51460.78222739275 61032.84872220252 69940.34775366646 63027.67483753643 64028.77256022237 65840.73308412632 58001.55519321571 0.928457882099125 1.06887135430414 1.0069217851506838 0.8872310760628016 1.0522622801904005 1.2058357318296045 1.0866549117101711 1.1039147544738879 1.1351546155063708 1.0 15.823803963228624 -6.520151924455759 24.967840332307443 1.113519326579144 0.9806082933254948 0.4784797526234237 0.06527842245649813 92.34060539107831 845517.4248766861 0.020786966304223168 0.021151420818099113 3.018895468709337e-07 6.520151924455759 -0.13291103325364928 AITS(ph)PLAAGSKPSK ddPTM_A459_Selumetinib_30min_R2 2 AITSPLAAGSKPSK 14 1 Q9UGU5;B0QXZ8;B0QXZ9 Q9UGU5 HMGXB4 HMG domain-containing protein 4 1 AIT(0.17)S(0.83)PLAAGSKPSK;AIT(0.236)S(0.764)PLAAGSKPSK 90.561 0.0099495 20870000.0 167928.0 150674.0 172673.0 160810.0 181995.0 155412.0 153195.0 149025.0 137907.0 153705.0 True False 158595.23402904623 162230.2113067291 161563.40717214718 138907.40058727705 159131.1610440567 176818.5923103282 160318.87105013354 149458.638077583 165492.25344352802 149267.13727644974 1.0624926351693904 1.0868447956248477 1.08237760916473 0.9305959980328024 1.0660830236821541 1.184578169961496 1.0740399660322786 1.0012829401342278 1.1086985150457371 1.0 17.18753705044567 -4.449800186677233 17.19622631854161 1.0615234070032171 1.0799734736214404 0.0 0.06570960371803225 365243.7684755187 145504.6686297205 0.016391270274404797 253254.51720636094 3.549766718839274e-05 4.449800186677233 0.018450066618223238 AITSLLGGGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AITSLLGGGSPK 12 0 A0A590UJS4;Q6KC79-2;Q6KC79 A0A590UJS4 NIPBL Nipped-B-like protein 1 AITSLLGGGS(1)PK;AITSLLGGGS(1)PK 166.03 0.00048722 426620000.0 7807.4 11049.1 12195.7 13501.5 8008.299999999999 9936.7 8822.3 9079.5 6277.200000000001 8327.2 True False 7989.297229444139 9755.466235412765 10539.590926184872 11143.716479543968 7283.950678980197 9836.74581980173 8156.82680812552 8838.682165627528 10651.949931451472 9396.077233796826 0.8502800722739241 1.0382488343458107 1.1217011806027872 1.1859966880073147 0.7752118780782788 1.0468992085782203 0.8681098085045708 0.9406778962858671 1.1336592565605343 1.0 13.19784285671353 -6.24150741525684 24.99683002455698 0.9574680215621918 1.053473567653774 0.11278105721812826 0.12085990168580824 1836.1072081948485 2302676.079687123 0.03588707497934922 0.0462697772410742 5.7344607529507e-07 6.24150741525684 0.0960055460915823 AITSLLGGGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AITSLLGGGSPK 12 0 A0A590UJS4;Q6KC79-2;Q6KC79 A0A590UJS4 NIPBL Nipped-B-like protein 1 AITSLLGGGS(1)PK;AITSLLGGGS(1)PK 173.25 0.00019135 103284000.0 172892.0 159121.0 169861.0 146094.0 133823.0 100315.0 134600.0 146181.0 90217.0 131962.0 True False 163283.35478151287 171325.06904534306 158932.3281906731 126195.74517379308 117010.95834720062 114132.48068109658 140859.16670484017 146606.36250843285 108262.92087359435 128151.9141815477 1.2741390233952796 1.3368904408453366 1.2401869235095468 0.9847355459319679 0.9130644602111512 0.8906030113558011 1.0991577270183464 1.1440044687958502 0.844801434024798 1.0 16.96749550249745 -5.701853225209226 4.069074053228566 0.9854304496891518 1.3010832774710672 0.7205509232924057 0.08651034040360904 0.11876528214776808 3.942435910929514 0.025545421356295988 0.044912143653165426 1.9867662543026834e-06 5.701853225209226 0.3156528277819154 AIVAIENPADVSVISSR ddPTM_A459_Selumetinib_30min_R2 2 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 ; 150.21 0.004799 4005400.0 21229.1 26109.0 30183.0 31689.0 36248.0 18629.2 18208.5 21361.5 21082.1 28898.0 False True 20049.271608820618 28111.476346333104 28241.05864076562 27372.903533425924 31694.20217876848 21195.203200959822 19055.231329458253 21423.658428413317 25299.10908309081 28063.63965397896 0.7144216450904279 1.0017045790547472 1.006322023407306 0.975386794832398 1.1293689118572603 0.7552549655815828 0.6790007128229547 0.7633955784981652 0.9014906617611096 1.0 14.77641450790243 -6.790156854768651 24.998380713954298 0.7962388181513672 0.9702792950401342 0.23603192063522804 0.12735193236545725 267.55720860255263 232904.98578019443 0.04474940461318795 0.039472034648247445 1.6212244516167276e-07 6.790156854768651 0.174040476888767 AIYHDLEQSIR ddPTM_A459_Selumetinib_30min_R2 2 AIYHDLEQSIR 11 0 A0A0U1RR22;Q9UNF0;Q9UNF0-2 A0A0U1RR22 PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2 0 ; 115.7 0.0085731 4602900.0 26935.0 24126.0 35339.0 33561.0 37322.0 34249.0 28959.0 26953.0 26965.0 30299.0 False True 25438.06052934807 25976.38662268308 33065.32721419398 28989.933904045804 32633.276697086647 38966.48886853289 30305.650881169884 27031.428767690635 32358.753465050606 29424.189143743803 0.8645288543068224 0.8828242129556254 1.1237464200852705 0.9852415562727468 1.1090629052738115 1.3243011958009379 1.029957044291686 0.9186804990831186 1.0997330566008394 1.0 14.844715038333367 -5.250351740770176 22.41559500235944 1.0764075394898391 0.8736763403582118 0.3752168323446937 0.10327384442847633 198.45105758920587 401193.2512453813 0.028049171974550792 0.07232197660926805 5.618860619969584e-06 5.250351740770176 -0.2027311991316273 AKADS(ph)PVNGLPK ddPTM_A459_Selumetinib_30min_R1 1 AKADSPVNGLPK 12 1 Q96S94;Q96S94-3;A0A0A0MSF3 Q96S94 CCNL2 Cyclin-L2 1 AKADS(1)PVNGLPK 89.46600000000002 0.014156 39135000.0 8563.4 8974.8 11507.0 11268.0 9336.7 8106.2 8289.0 8536.8 5314.2 8221.7 True False 8762.910558524212 7924.026243728679 9944.412603426557 9300.255326556407 8492.197133528265 8024.658987840708 7663.754056487817 8310.376332565565 9017.80926618865 9277.0352811398 0.9445809240737929 0.8541550186661695 1.0719386422560593 1.0025029596970287 0.9153998962139219 0.8650025298658536 0.8260994837508291 0.8958008761118489 0.9720572351947224 1.0 13.179448112798603 -6.436731480436139 6.348317279645013 0.8988896101016016 0.9671460353461829 0.12287668454630907 0.06895814691197352 0.4516114383108337 27.4185864601762 0.022520567343358434 0.02545228915830716 3.6582090479868084e-07 6.436731480436139 0.06825642524458131 AKADS(ph)PVNGLPK ddPTM_A459_Selumetinib_30min_R2 2 AKADSPVNGLPK 12 1 Q96S94;Q96S94-3;A0A0A0MSF3 Q96S94 CCNL2 Cyclin-L2 1 AKADS(1)PVNGLPK;AKADS(1)PVNGLPK 98.552 0.008347799999999999 89532000.0 614200.0 504240.0 545080.0 566970.0 531680.0 414310.0 460820.0 456540.0 317040.0 470310.0 True False 580065.2228374083 542913.5866128538 510010.1462382305 489747.70792219776 464885.6051204927 471377.44176828087 482249.0430975071 457868.4558157344 380456.8588377391 456730.9282878699 1.2700370982361038 1.188694596724714 1.1166534049929275 1.072289344971878 1.017854444110435 1.0320681446630202 1.0558712213891361 1.0024905857199746 0.8329999903092691 1.0 18.800984961934418 -2.418267377920433 0.30539496114005044 0.9470604223652953 2.679186693254379 0.7874628175046068 0.05155078125644406 14.471974849469586 0.33952018527645716 0.05332637115461286 12.418990461518765 0.003817091952430134 2.418267377920433 1.7321262708890837 AKAGLESGAEPGDGDS(ph)DTTK ddPTM_A459_Selumetinib_30min_R1 2 AKAGLESGAEPGDGDSDTTK 20 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AKAGLESGAEPGDGDS(0.93)DT(0.053)T(0.016)K;AKAGLESGAEPGDGDS(0.638)DT(0.273)T(0.09)K 121.84 0.0020829 5230100.0 2929.0 3042.6 6382.5 6495.1 4335.0 3738.4 3721.3 3819.5 2610.3999999999996 2811.5 True False 2997.240001158117 2686.3709775336356 5515.791556562961 5360.852713127137 3942.9000154064133 3700.795090195618 3440.5993449641824 3718.1944525154854 4429.658143927373 3172.38341132911 0.9447912224148171 0.8467989612920548 1.7386900766361184 1.6898501908636383 1.242882559947092 1.1665661461283217 1.0845471366031068 1.1720507802547426 1.3963186568522348 1.0 11.631351429031673 -6.520144570811709 24.325778253112023 1.1735829868929561 1.3236632829936033 0.05280214468413569 0.2765872211305744 283.39658250210164 2521399.309232404 0.10003931683789673 0.10192378940222575 3.0189465862610814e-07 6.520144570811709 0.1500802961006471 AKAGLESGAEPGDGDS(ph)DTTK ddPTM_A459_Selumetinib_30min_R2 2 AKAGLESGAEPGDGDSDTTK 20 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 AKAGLESGAEPGDGDS(0.928)DT(0.055)T(0.017)K;AKAGLESGAEPGDGDS(0.878)DT(0.101)T(0.021)K 142.45 2.7524e-05 9799300.0 67739.0 93855.0 70256.0 77887.0 58945.0 35353.0 34989.0 31773.0 22157.0 73419.0 True False 63974.33756070195 101053.37670860997 65735.8054489491 67278.65623743077 51539.80212501402 40222.554847418694 36616.0578293882 31865.45416969669 26589.01911830621 71299.202704529 0.8972658197289803 1.417314259843623 0.9219711154606431 0.9436102184233423 0.722866458108937 0.5641375123660916 0.5135549408754091 0.44692581348700783 0.37292168929986147 1.0 16.121598323530627 -6.183304837578234 1.2606211141365697 0.533321762377641 1.140255653174738 0.5413234389112825 0.20461107932670344 0.3018331397763577 0.9765277018066524 0.0761194222642136 0.11827240833487007 6.556848700486762e-07 6.183304837578234 0.6069338907970971 AKDQNES(ph)LDEEMFYK ddPTM_A459_Selumetinib_30min_R1 2 AKDQNESLDEEMFYK 15 1 A0A0U1RRM8;H0YJ34;Q96AC1;Q96AC1-3 A0A0U1RRM8 FERMT2 Fermitin family homolog 2 1 AKDQNES(1)LDEEMFYK;AKDQNES(1)LDEEMFYK 109.77 0.0020154 19358300.0 4420.1 5617.6 6142.8 6771.9 5649.3 5112.7 4589.6 4465.5 3073.06 3709.5 True False 4523.0797299825845 4959.888780448615 5308.641499985107 5589.31478930665 5138.321812464925 5061.270879960178 4243.402776891844 4347.060434011753 5214.75837257794 4185.650458589837 1.0806157309911704 1.1849744333691021 1.268295466261559 1.3353515408426417 1.2276041354384968 1.2091957821211234 1.013797692586462 1.0385626982039717 1.2458657081305382 1.0 12.031236122601962 -7.165329678878793 6.370139615764332 1.0782195720115415 1.2254927966293223 0.3895549136429266 0.08752254969094424 0.26512063809168107 14.725252864433306 0.03502252443566022 0.02703639928351208 6.833926776030964e-08 7.165329678878793 0.1472732246177808 AKEAAEQDVEK ddPTM_A459_Selumetinib_30min_R2 1 AKEAAEQDVEK 11 1 P26373-2;P26373;J3KS98 P26373-2 RPL13 60S ribosomal protein L13 0 105.66 0.032598 6077200.0 38988.0 42114.0 37700.0 43453.0 39976.0 29940.0 29140.0 31033.0 22175.0 47042.0 False True 36821.203041329994 45344.00838214684 35274.42304465641 37534.62643939401 34953.8574900256 34063.96323174034 30495.06773981456 31123.300892210293 26610.61962126822 45683.77523020551 0.8060017556732987 0.992562636376995 0.7721433455730127 0.8216183152607889 0.7651262907649228 0.7456468529601226 0.6675251243170381 0.6812769026941534 0.5824960719024296 1.0 15.479394257063788 -6.018795639079378 1.0352834229763024 0.7105232870871907 0.891192454220259 0.1797715831099569 0.1141067255599583 0.7482471391333413 1.6350397754957664 0.04507203715021155 0.09248781434432225 9.576445930046113e-07 6.018795639079378 0.18066916713306824 AKEAAGPAPS(ph)PMR ddPTM_A459_Selumetinib_30min_R1 1 AKEAAGPAPSPMR 13 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 AKEAAGPAPS(1)PMR 110.22 0.026910000000000003 7541700.0 670.87 684.8 1035.1 1328.8 952.09 652.99 700.47 673.0 288.72 641.18 True False 686.4999657142189 604.6232976451171 894.539105397308 1096.7500246652603 865.9736276051422 646.4215134674821 647.6329839483674 655.1498537879094 489.93675272552565 723.4816986220874 0.9488836649519921 0.8357133273677233 1.2364363979089026 1.5159333356380458 1.196953052515964 0.8934870290411342 0.8951615295615932 0.9055513844174359 0.6771930149147358 1.0 9.498812712210915 -6.79260482513705 7.455928981376358 0.8684923915926744 1.1550263104170417 0.35293808924105274 0.18428255774488753 0.24978438950403042 45.88591451297715 0.07262761946598673 0.06505450871052933 1.6121118668705782e-07 6.79260482513705 0.2865339188243673 AKFEELNMDLFR ddPTM_A459_Selumetinib_30min_R1 1 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 142.1 0.0026407 13371000.0 4739.1 4911.0 5462.3 5749.7 5094.5 4494.6 4973.8 5117.8 2703.4 3631.8 False True 4849.511809316638 4336.017836938037 4720.549662266174 4745.622830236192 4633.70337450703 4449.388404770284 4598.622261570648 4982.059319042741 4587.472351476123 4097.97690672775 1.1833916880680988 1.0580874259734088 1.1519219775290415 1.1580404034110552 1.1307294989631993 1.0857524349309078 1.1221689058376527 1.2157363090220372 1.119448073010064 1.0 12.000696139034861 -12.02344339673366 1.7358000423929194 1.883980923333037e-05 1.1352432331873823 0.47487269723217074 0.04294001079867187 667237.9960154829 46351.64731439246 2613839.2372226533 0.010838041087790108 9.474506613378053e-13 12.02344339673366 1.135224393378149 AKGSET(ph)PGATPGSK ddPTM_A459_Selumetinib_30min_R1 2 AKGSETPGATPGSK 14 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 AKGS(0.002)ET(0.949)PGAT(0.009)PGS(0.039)K;AKGS(0.003)ET(0.947)PGAT(0.037)PGS(0.013)K 155.1 0.0034357 67004100.0 10111.25 11826.5 18197.6 19022.2 14328.8 14269.6 12148.69 12903.46 8192.95 9221.67 True False 10346.822451932403 10441.847882009311 15726.465872261668 15700.329860917765 13032.76256995511 14126.060779760166 11232.304532333574 12561.218324454894 13902.837760607497 10405.361171172442 0.9943741770922648 1.0035065299739863 1.5113810672743482 1.5088692840777869 1.2525045844695673 1.357575248699271 1.079472816710307 1.2071871526434999 1.3361225556614649 1.0 13.34503942158726 -7.256171463711409 24.7409036150557 1.172961229788366 1.2800406372442965 0.08287577207370755 0.18362351385683298 1248.9358673103454 5865683.349968492 0.07814598625860474 0.05861719148927711 5.544067845193232e-08 7.256171463711409 0.10707940745593048 AKGSETPGATPGS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 AKGSETPGATPGSK 14 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 AKGS(0.035)ET(0.102)PGAT(0.063)PGS(0.8)K 79.089 0.020215 13448000.0 8430.3 8814.9 16527.0 16610.0 13001.0 11668.0 9780.7 10617.0 6240.2 7912.7 True False 8626.709587491734 7782.8474100641715 14282.72417631274 13709.375308315759 11825.061845512977 11550.630513696355 9042.933924513249 10335.402671123684 10589.163633824557 8928.372121224917 0.9662130420151219 0.8716983683467276 1.5997008169450313 1.5354843102613558 1.324436491328797 1.2936994960411305 1.0128312083919522 1.1575909394002422 1.1860128016675666 1.0 13.124181442458436 -7.245192075123393 23.78567775439919 1.1022413158885958 1.2775008166941402 0.13593110754997817 0.21515996291625253 1025.45356704074 1501241.7315920263 0.09195627534190615 0.07097053633588538 5.686014002735188e-08 7.245192075123393 0.17525950080554442 AKMPIVGLGTWKS(ph)PLGK ddPTM_A459_Selumetinib_30min_R1 1 AKMPIVGLGTWKSPLGK 17 2 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 AKMPIVGLGT(0.276)WKS(0.724)PLGK 62.468 0.020513 13123000.0 2816.9 2604.7 7397.0 8612.5 4538.6 4393.1 3209.1 3469.6 2143.2 2117.1 True False 2882.528289266748 2299.740513107821 6392.5280288125705 7108.488551647774 4128.08443135491 4348.909402615655 2967.035003338768 3377.574937150864 3636.8538668652905 2388.8504073003223 1.2066591865517182 0.9626975829377252 2.6759850718475366 2.9756943046430395 1.728063179987952 1.8205030291245514 1.242034659965109 1.4138913541128408 1.5224284684177258 1.0 11.222100797977811 -7.119271659823898 2.824161230868367 1.325898048313094 1.9533386679532405 0.20363360610592462 0.5766091574188635 0.5302837031391472 8.161785287599884 0.2737674584318494 0.20457665154605842 7.598508264705705e-08 7.119271659823898 0.6274406196401465 AKNS(ph)PPQAPSTR ddPTM_A459_Selumetinib_30min_R2 1 AKNSPPQAPSTR 12 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 AKNS(1)PPQAPSTR 75.89 0.026836 28499000.0 82334.0 65497.0 81198.0 92802.0 85644.0 69080.0 63779.0 71643.0 62535.0 69447.0 True False 77758.20588911625 70520.40929395152 75973.80908169782 80162.20750762081 74884.63505292553 78595.14295419575 66744.84987569106 71851.46926886293 75043.74737389 67441.88466502438 1.1529660874000152 1.0456470729461047 1.126507799404635 1.1886116158493603 1.1103579833936785 1.1653758394292841 0.9896646602805451 1.0653834723887154 1.1127172342027976 1.0 16.041357232539006 -7.252109758057204 24.997238974454543 1.0473899630362706 1.1290692574457812 0.45489333612290683 0.047874727163092164 699.6545088370433 1874616.2208759044 0.018804329461666276 0.01434566914130587 5.59616153361317e-08 7.252109758057204 0.0816792944095106 AKNWEDEDFYDS(ph)DDDTFLDR ddPTM_A459_Selumetinib_30min_R1 2 AKNWEDEDFYDSDDDTFLDR 20 1 A0A087X0M4;Q9BWU0;A0A087WWF4 A0A087X0M4 SLC4A1AP Kanadaptin 1 AKNWEDEDFYDS(0.967)DDDT(0.033)FLDR;AKNWEDEDFYDS(0.999)DDDT(0.001)FLDR 97.152 0.0050838 0.0 2843.0299999999997 3273.1 3828.9 4095.6 3520.0 3429.7000000000003 3053.8500000000004 2704.86 2135.8500000000004 2384.4 True False 2909.2670674266187 2889.8839303770933 3308.956410642213 3380.3803439336552 3201.616621506476 3395.2003319184428 2823.4956358312616 2633.1183261764713 3624.381453688051 2690.4609660228107 1.081326621782311 1.0741222291914834 1.2298845634373565 1.256431662314998 1.1899881328660509 1.2619400076030158 1.049446794244003 0.978686685824286 1.34712285346619 1.0 11.393637660574333 -7.276253100448081 24.544804294976903 1.0920379755146896 1.1832502879999673 0.1311981872152307 0.11147507497845904 1393.8907552114918 2309522.8173624985 0.04683306761903412 0.031731952773592975 5.2935485374230144e-08 7.276253100448081 0.09121231248527772 AKPAMPQDSVPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 AKPAMPQDSVPSPR 14 1 P53396 P53396 ACLY ATP-citrate synthase 1 AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDS(0.001)VPS(0.999)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR 195.38 0.00029221 554491000.0 23836.3 28267.7 30075.3 34084.600000000006 30019.700000000004 24660.2 29254.3 27141.2 14518.710000000001 22856.800000000003 True False 24391.639412634075 24958.104542702808 25991.239451797574 28132.364457183576 27304.423435408517 24412.140777670116 27047.62459822795 26421.327208957526 24637.1904653769 25790.692924085804 0.9457535508809397 0.967717486930898 1.007775926311948 1.0907952159327559 1.0586928980845274 0.9465484641892554 1.0487358628882866 1.0244520101390053 0.9552744681151373 1.0 14.654562914394797 -5.2256516509073645 3.410543040060541 1.0206605284719688 0.9519590748398569 0.2504132852863177 0.04184105373239331 0.32998343213893333 7.921856803681354 0.011464293339617737 0.034015037993206244 5.947690336191191e-06 5.2256516509073645 -0.06870145363211189 AKPAMPQDSVPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 AKPAMPQDSVPSPR 14 1 P53396 P53396 ACLY ATP-citrate synthase 1 AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR;AKPAMPQDSVPS(1)PR 179.97 0.00034758 1373990000.0 523789.0 507122.0 539416.0 607928.0 561818.0 443444.0 433183.0 454712.0 386120.0 473608.0 True False 494678.90427349886 546016.6267457637 504710.56183173443 525127.1576657058 491237.400123354 504524.385816161 453326.86783583066 456035.13663837593 463354.78909420944 459933.70645863534 1.0755439258461663 1.187163756598627 1.0973550203960234 1.1417453217530897 1.0680613167183344 1.0969502315906825 0.9856352371439016 0.9915236266324612 1.0074382081320274 1.0 18.811066404615644 -7.019971697044808 1.4081054484633395 0.9921095051061386 1.1253928153186348 0.7364580002003299 0.033363780640845414 0.19762380932963597 0.7941665803815727 0.01663845857401476 0.01201877224127255 9.550548248806889e-08 7.019971697044808 0.13328331021249618 AKPPADPAAAAS(ph)PCR ddPTM_A459_Selumetinib_30min_R1 3 AKPPADPAAAASPCR 15 1 Q9GZT9;Q9GZT9-2 Q9GZT9 EGLN1 Egl nine homolog 1 1 AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR 165.24 0.00041627 193155000.0 13322.3 16490.3 18097.6 19184.6 16078.9 13749.400000000001 15484.0 13312.6 7216.1 13086.9 True False 13632.683669316766 14559.60800986752 15640.045323000988 15834.369749543315 14624.566333960358 13611.093519456348 14316.029413760085 12959.506602580874 12245.194656908645 14766.731092200933 0.923202541185089 0.9859736673580515 1.0591406605393727 1.0723002708369396 0.9903726317386751 0.9217404606660078 0.9694785748025921 0.8776151283357122 0.8292420699240578 1.0 13.850062871933375 -6.728943593493 3.2678268756874553 0.9132038719070481 1.0140150729698862 0.3590612380542837 0.057922563163288386 0.2700196754159785 5.950962144652931 0.02191969543188767 0.020821234030817117 1.8666221134314128e-07 6.728943593493 0.10081120106283814 AKPPADPAAAAS(ph)PCR ddPTM_A459_Selumetinib_30min_R2 6 AKPPADPAAAASPCR 15 1 Q9GZT9;Q9GZT9-2 Q9GZT9 EGLN1 Egl nine homolog 1 1 AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR;AKPPADPAAAAS(1)PCR 168.42 0.00021781 253039000.0 590979.0 563703.0 656397.0 635084.0 680263.0 561905.0 536726.0 505723.0 412378.0 495178.0 True False 558134.7530563795 606937.2075091726 614165.1316510161 548584.4636189932 594802.2803116186 639302.3132842695 561684.8225023926 507194.5702030506 494865.1228040284 480880.9245130449 1.1606506405334425 1.2621361683742733 1.2771667586376794 1.140790652435438 1.2369013824242125 1.329439952170378 1.1680330698731132 1.0547196703979302 1.0290803764053322 1.0 18.875320173251268 -7.705616512370987 2.991834963214945 1.0234408665928796 1.2345103739382373 0.7589958423673577 0.05211505384406052 0.1272309700406782 2.2936279317675745 0.03077411900689514 0.014964026029935988 1.9696247261002022e-08 7.705616512370987 0.21106950734535768 AKPPS(ph)SSSTCTDSATR ddPTM_A459_Selumetinib_30min_R2 1 AKPPSSSSTCTDSATR 16 1 D6RJC6;A0A087WYP9;A6NFV8;Q96EV8-3;Q96EV8;D6RAR7 D6RJC6 DTNBP1 Dysbindin 1 AKPPS(0.445)S(0.445)S(0.025)S(0.025)T(0.025)CT(0.036)DSATR 68.08800000000001 0.026813 1257700.0 3643.5 4561.1 4187.2 3387.3 3290.2 2432.5 1177.7 3703.2 999.19 3626.4 True False 3441.0088560861204 4910.921703751963 3917.8001106786546 2925.943896581577 2876.855661238799 2767.5547949635384 1232.4653835682775 3713.9756989022367 1199.0559197012403 3521.696409481254 0.9770884414744261 1.3944761651034372 1.1124752548604118 0.8308336541174396 0.8168948503038511 0.7858584253635876 0.3499635517275664 1.054598485236638 0.3404767987589996 1.0 11.782054830567755 -5.848771830686019 2.0028711004030852 0.7088899061447355 1.2054680779904139 0.4000075511602451 0.23980357918800344 0.29693755474714983 2.4307267374658177 0.07026033006293601 0.12747289563788922 1.4165378040773043e-06 5.848771830686019 0.49657817184567843 AKPPTEGAGS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 AKPPTEGAGSPAK 13 1 K7EPQ1;A0A0R4J2E4;K7ENL6;Q8TES7-4;Q8TES7-3;Q8TES7-2;Q8TES7-5;Q8TES7;Q8TES7-6 K7EPQ1 FBF1 Fas-binding factor 1 1 AKPPTEGAGS(1)PAK 77.505 0.023635 3465700.0 37492.0 42406.0 38856.0 43469.0 37774.0 30057.0 35593.0 37803.0 30699.0 31960.0 True False 35408.344732367485 45658.40384321887 36356.047263214066 37548.44721179245 33028.49241615537 34197.07891972006 37248.1450261915 37913.00047137646 36839.65780172776 31037.23175794751 1.1408344986598455 1.4710849279116978 1.1713688755088347 1.2097872485737282 1.064157160462546 1.101808279372835 1.2001117018644423 1.2215329242972293 1.1869505015470478 1.0 14.921712267384471 -5.4889089455650115 24.396734682331367 1.1508388056754468 1.3097766038377123 0.2959398638948152 0.09971775466155085 531.3729680884713 381624.8408913005 0.02485888094485871 0.05169120787577752 3.2440762571223706e-06 5.4889089455650115 0.1589377981622655 AKS(ph)IVFHR ddPTM_A459_Selumetinib_30min_R2 1 AKSIVFHR 8 1 F5H018;B5MDF5;J3KQE5;P62826;B4DV51 F5H018 RAN GTP-binding nuclear protein Ran 1 AKS(1)IVFHR 65.278 0.046907 19069000.0 85838.0 98359.0 94669.0 99484.0 101630.0 82591.0 65455.0 66351.0 64282.0 98029.0 True False 81067.46759673949 105902.81902596696 88578.09960781377 85934.10758052784 88862.33081627231 93967.16056354917 68498.7871966219 66544.07042500057 77140.19618914828 95198.6480600701 0.8515611224393241 1.1124403674214214 0.9304554362150312 0.9026820163066143 0.9334411005521887 0.9870640232648696 0.7195352937512236 0.6990022629629302 0.8103076856771434 1.0 16.53865346515324 -7.255023126691015 24.82057199568018 0.782128164218706 0.9559977827065136 0.3273630775731806 0.09971971271482143 453.44648089932616 1754111.887592853 0.037387745248304106 0.028244182504390813 5.558746555042546e-08 7.255023126691015 0.17386961848780758 AKS(ph)LSAMDVEK ddPTM_A459_Selumetinib_30min_R2 2 AKSLSAMDVEK 11 1 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AKS(0.874)LS(0.126)AMDVEK;AKS(0.964)LS(0.036)AMDVEK 120.3 0.022641 34198000.0 126697.0 153745.0 143167.0 140681.0 127379.0 103164.0 108674.0 102567.0 73279.0 139995.0 True False 119655.68794827609 165536.74713190758 133955.79108844372 121520.00511173904 111376.51123729176 117373.90457044948 113727.55633344587 102865.45298911913 87936.8475863319 135952.98059930713 0.8801255214914052 1.2176029271457636 0.9853097041193255 0.8938384769208829 0.8192281680498837 0.8633418999204174 0.8365212430953166 0.7566252136265659 0.646818092539709 1.0 17.052748255433187 -5.836032491592272 2.2120226586086322 0.8116873077167142 1.0572820831027445 0.4023331809687952 0.11312631639004322 0.27133247539404803 2.707986354390806 0.033624799285800394 0.05977934434784401 1.4587051236708382e-06 5.836032491592272 0.24559477538603036 AKS(ph)PAPGLASGDRPPSVSSVHSEGDCNR ddPTM_A459_Selumetinib_30min_R2 1 AKSPAPGLASGDRPPSVSSVHSEGDCNR 28 2 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 AKS(0.993)PAPGLAS(0.005)GDRPPS(0.001)VS(0.001)S(0.001)VHSEGDCNR 46.787 0.017407 23864000.0 3847.6 2096.7 5056.4 8172.1 9123.2 5248.9 2325.5 5204.9 5436.8 5752.5 True False 3633.7657951631577 2257.510148046905 4731.076728992062 7059.0458823411855 7977.062053557175 5971.8883302298555 2433.6403578908316 5220.045397282419 6524.311916884376 5586.410378210045 0.6504652449696081 0.4041074670869847 0.8468902942479422 1.2636103337261433 1.4279405760579167 1.0690027989213573 0.4356358006535496 0.9344185342421955 1.1678898389442787 1.0 12.447705842680584 -5.462870417750124 4.934856923026091 1.0339739303593183 0.5376667256296795 0.39874727852534364 0.2506703701095002 0.23485871812857623 11.638839451956727 0.07478045023620586 0.15701343888569289 3.4445269121337105e-06 5.462870417750124 -0.49630720472963874 AKS(ph)PNGSSSVNWPPEFRPGEPWK ddPTM_A459_Selumetinib_30min_R1 1 AKSPNGSSSVNWPPEFRPGEPWK 23 2 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 AKS(0.672)PNGS(0.109)S(0.109)S(0.109)VNWPPEFRPGEPWK 83.42299999999999 0.0004052 13105000.0 700.82 927.78 1274.8 1016.8 1117.1 695.02 1097.8 1051.9 548.79 940.88 True False 717.1477424416632 819.1550862867794 1101.689161975161 839.2349676999078 1016.0585022400234 688.0287298276692 1014.992062156149 1024.0001949472537 931.2565479642601 1061.6511129473 0.6755022753668627 0.7715859535178974 1.0377130005701303 0.7904997766828199 0.9570549965508869 0.6480742321435523 0.9560504856801605 0.9645355074365988 0.8771775742587927 1.0 10.052094020373994 -5.023555474387046 9.357757233292407 0.8940219468258178 0.6989629357600071 0.3215771077453031 0.10803444911575388 0.35389505190647974 139.94964660802364 0.026637293820957326 0.0761634919369883 9.472061858711833e-06 5.023555474387046 -0.1950590110658107 AKS(ph)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R1 9 AKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 AKS(0.71)PQPPVEEEDEHFDDT(0.29)VVCLDTYNCDLHFK;AKS(0.581)PQPPVEEEDEHFDDT(0.419)VVCLDTYNCDLHFK;AKS(0.621)PQPPVEEEDEHFDDT(0.379)VVCLDTYNCDLHFK;AKS(0.746)PQPPVEEEDEHFDDT(0.254)VVCLDTYNCDLHFK;AKS(0.987)PQPPVEEEDEHFDDT(0.013)VVCLDTYNCDLHFK;AKS(0.963)PQPPVEEEDEHFDDT(0.037)VVCLDTYNCDLHFK;AKS(0.99)PQPPVEEEDEHFDDT(0.01)VVCLDTYNCDLHFK;AKS(0.999)PQPPVEEEDEHFDDT(0.001)VVCLDTYNCDLHFK;AKS(0.894)PQPPVEEEDEHFDDT(0.106)VVCLDTYNCDLHFK 101.73 1.5847e-09 924416000.0 90142.0 119744.0 87973.8 107788.79999999999 79505.0 88428.9 80454.36000000002 69906.03 55942.18 66999.58 True False 92242.13321420114 105724.31681252479 76027.44116549288 88965.50952636889 72313.78678774777 87539.38555301716 74385.6228510231 68051.8949976125 94929.79360483128 75599.62872417498 1.2201400294007565 1.3984766671045388 1.005658922517712 1.1767982333743896 0.9565362688695788 1.1579340670098308 0.9839416423911131 0.9001617619829806 1.2556912673629965 1.0 16.206091528822427 -5.267154505392547 24.997581870020905 1.0530549405374832 1.3093083534882444 0.45205867165254854 0.11216307212732239 347.77692207952157 1521159.0978746458 0.02764951705594534 0.060126398707741516 5.405619774235266e-06 5.267154505392547 0.2562534129507612 AKS(ph)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R2 4 AKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 AKS(0.519)PQPPVEEEDEHFDDT(0.48)VVCLDTYNCDLHFK;AKS(0.866)PQPPVEEEDEHFDDT(0.115)VVCLDT(0.014)Y(0.005)NCDLHFK;AKS(0.951)PQPPVEEEDEHFDDT(0.049)VVCLDTYNCDLHFK;AKS(0.968)PQPPVEEEDEHFDDT(0.032)VVCLDTYNCDLHFK 72.028 3.3227e-05 35038300.0 69989.8 71202.0 76406.0 77266.0 72506.0 51292.0 63671.9 64810.0 57028.0 73793.5 True False 66100.04710736833 76662.96444948531 71490.12114456289 66742.23750871561 63397.14806813581 58357.007417582645 66632.76951347638 64998.58637012691 68435.19349545355 71662.88991646137 0.9223748467920043 1.0697721587679845 0.9975891459010391 0.9313361153383314 0.8846579888424668 0.8143267385059462 0.929808574440011 0.9070048172198589 0.9549600019651678 1.0 16.128938603171783 -5.828055436316668 3.691784193566281 0.906431162239435 1.0049960810182286 0.286050429099042 0.05630338494220139 0.24138741911859427 6.551056671968088 0.016076567794680693 0.02581944950436411 1.4857459794084095e-06 5.828055436316668 0.09856491877879359 AKS(ph)PTPDGSER ddPTM_A459_Selumetinib_30min_R1 3 AKSPTPDGSER 11 1 J3QR07;Q96MU7;Q96MU7-2 J3QR07 YTHDC1 YTH domain-containing protein 1 1 AKS(0.969)PT(0.031)PDGS(0.001)ER;AKS(0.974)PT(0.026)PDGSER;AKS(0.977)PT(0.023)PDGSER 170.0 0.0018441 30019500.0 7680.3 9068.5 8695.5 8616.4 7875.8 8662.0 7194.4 8699.7 6505.6 6895.6 True False 7859.236046737694 8006.755804168732 7514.698860962513 7111.707489859836 7163.435280585422 8574.868144466733 6651.720615755333 8468.955695391796 11039.528049775487 7780.717428831947 1.0100914367632465 1.02905109681778 0.9658105347864601 0.9140169341591752 0.9206651373870556 1.1020665154465075 0.8548981088950688 1.0884543453550362 1.418831637410171 1.0 12.92568747114586 -8.002965946920366 24.603975065596735 1.2241582324801403 0.9737414779030044 0.4144920498414495 0.11382583263677995 74.80072931558627 620502.7463894938 0.059076732758677086 0.02751211890495108 9.931939218160361e-09 8.002965946920366 -0.25041675457713597 AKS(ph)PTPDGSER ddPTM_A459_Selumetinib_30min_R2 3 AKSPTPDGSER 11 1 J3QR07;Q96MU7;Q96MU7-2 J3QR07 YTHDC1 YTH domain-containing protein 1 1 AKS(0.909)PT(0.091)PDGSER;AKS(0.929)PT(0.071)PDGSER;AKS(0.951)PT(0.048)PDGSER 164.22 0.000279 10312700.0 67411.7 52372.3 48771.2 59923.1 59850.3 42254.9 76857.7 104084.8 56424.2 97726.0 True False 63665.22758441626 56389.087006513495 45633.314090067564 51761.470406886765 52331.3702455293 48075.12892320856 80431.73534064334 104387.66953583376 67710.61662387203 94904.3964573584 0.6708353876210756 0.5941672789821675 0.48083456397692936 0.5454064546961612 0.5514114435050685 0.5065637706764118 0.8475027326766913 1.0999244864566027 0.7134613268869495 1.0 16.53418730136182 -7.362753907193158 4.413303927397104 0.936389940220407 0.5557473848023852 0.7465875823116264 0.10259348487277924 0.1093095943050711 3.5943910014985287 0.04283642671512114 0.028190006040363542 4.3375659677727245e-08 7.362753907193158 -0.38064255541802183 AKS(ph)PTPESSTIASYVTLR ddPTM_A459_Selumetinib_30min_R1 1 AKSPTPESSTIASYVTLR 18 1 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 AKS(0.87)PT(0.114)PES(0.008)S(0.008)TIASYVTLR 148.19 0.00095277 36662000.0 1540.2 1883.2 1612.0 2027.3 1981.3 1681.0 1738.3 1675.1 1144.4 1336.4 True False 1576.0836632925 1662.714068524071 1393.0992540821771 1673.2701121341693 1802.0917648269258 1664.0906662258813 1607.1786314866415 1630.6709065083605 1941.9632163310173 1507.9399576383507 1.045189933000298 1.1026394387268037 0.9238426550245207 1.1096397463694438 1.1950686469302523 1.1035523382721981 1.0658107594706308 1.0813898114764622 1.287825292044392 1.0 10.558363269938477 -5.971457140360879 24.894780058115664 1.125291028004934 1.0292614265816278 0.21940577504743664 0.08347041509265761 306.5697634460828 267384.8439469559 0.022966696705240257 0.034064589389006805 1.0679301791961695e-06 5.971457140360879 -0.09602960142330619 AKS(ph)PTPESSTIASYVTLR ddPTM_A459_Selumetinib_30min_R2 1 AKSPTPESSTIASYVTLR 18 1 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 AKS(0.843)PT(0.153)PES(0.003)S(0.001)TIASYVTLR 52.654 0.044284 52526000.0 12244.0 10049.0 13546.0 14086.0 12412.0 7948.9 8123.1 12084.0 7316.1 10859.0 True False 11563.527496615478 10819.72598737222 12674.465107769647 12167.46250029466 10852.693595312136 9043.788822070166 8500.840245617286 12119.162439386102 8779.524428913655 10545.472454929668 1.0965395382745418 1.0260067563226478 1.2018868914540424 1.1538091396376238 1.029132989697285 0.8575992076905465 0.8061127921910618 1.149228969226579 0.8325396957259616 1.0 13.364336111297009 -6.526301531942024 5.069895754033084 0.930950587163231 1.1166818377636059 0.44519151769256393 0.1002394278751781 0.17602904558773644 13.431791532440599 0.03313330393640467 0.03479701642554411 2.97644915441204e-07 6.526301531942024 0.18573125060037488 AKS(ph)TCSCPDLQPNGQDLGENSR ddPTM_A459_Selumetinib_30min_R2 1 AKSTCSCPDLQPNGQDLGENSR 22 1 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 AKS(0.417)T(0.417)CS(0.167)CPDLQPNGQDLGENSR 76.818 0.0009056 4946300.0 10583.0 11663.0 11660.0 14677.0 14450.0 12947.0 11189.0 10775.0 11255.0 15765.0 True False 9994.839227105645 12557.51459754426 10909.80829444811 12677.967280762798 12634.661815360969 14730.331728835734 11709.31067058288 10806.35346610272 13506.314490975137 15309.82348761085 0.6528383057579832 0.8202259554269951 0.7126018339320921 0.8280936283179341 0.8252650218720876 0.9621490241710455 0.7648233619452497 0.7058444190978121 0.8821992299195895 1.0 13.90217002913983 -14.522878745280336 0.09456462170181722 1.589247054826338 0.6561979682586623 0.4139086855799201 0.08098751216760326 234.10593528503253 1.5182465316699363 28.17036001518444 1.7234466853509265 3.0000000000000132e-15 14.522878745280336 -0.9330490865676757 AKS(ph)VDEIAK ddPTM_A459_Selumetinib_30min_R2 1 AKSVDEIAK 9 1 A6ND36;A6ND36-2 A6ND36 FAM83G Protein FAM83G 1 AKS(1)VDEIAK 78.903 0.027661 37937000.0 175810.0 177720.0 175580.0 149150.0 125060.0 90668.0 125370.0 93289.0 106960.0 128210.0 True False 166039.18402319227 191350.55254013234 164283.3739570495 128835.51270189902 109348.84474941471 103156.69399784348 131199.95341594223 93560.45554517463 128354.9887121017 124508.24417041466 1.333559758468155 1.5368504617110372 1.3194578001774289 1.034754875553153 0.8782458180018083 0.8285129606088792 1.0537451097324015 0.7514398437513765 1.0308955006740115 1.0 16.925881746288375 -5.768928128363689 2.5862861113583735 0.9146447250089618 1.4370242498911165 0.822405585421938 0.09916253114753397 0.09626134328834317 1.3133148859072021 0.027326887729671175 0.04921494889201982 1.7024402228668527e-06 5.768928128363689 0.5223795248821548 AKSPQPPVEEEDEHFDDT(ph)VVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R1 2 AKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 AKS(0.069)PQPPVEEEDEHFDDT(0.928)VVCLDT(0.003)Y(0.001)NCDLHFK;AKS(0.044)PQPPVEEEDEHFDDT(0.954)VVCLDT(0.001)YNCDLHFK 56.854 0.00090426 145519000.0 2351.94 2904.19 2227.5699999999997 2808.58 2831.0 2159.1499999999996 2261.52 1979.76 1251.1200000000001 1701.07 True False 2406.7356259214157 2564.1660846786986 1925.0782291661512 2318.114226576127 2574.936549853646 2137.430911351343 2090.9317256398017 1927.250333633212 2123.059261810612 1919.4189043249555 1.2538876326050594 1.3359074868445644 1.0029484573838696 1.2077166799560044 1.3415188024102693 1.1135822964623039 1.0893566385786775 1.0040801042912573 1.1060947962046228 1.0 10.906453892098972 -6.973990021291003 10.772909896254138 1.0574948058160325 1.2214530408294428 0.45377268309047936 0.09275618932413333 0.5018873882861135 203.70303131714246 0.033988409240580914 0.029863633438934254 1.0617199518736815e-07 6.973990021291003 0.16395823501341034 AKSPQPPVEEEDEHFDDT(ph)VVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R2 2 AKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 AKS(0.242)PQPPVEEEDEHFDDT(0.757)VVCLDT(0.001)YNCDLHFK;AKS(0.033)PQPPVEEEDEHFDDT(0.966)VVCLDTYNCDLHFK 69.578 8.2056e-05 12662900.0 54603.0 61087.0 60013.0 57733.0 58534.0 40068.0 48881.0 45392.0 47581.0 65859.0 True False 51568.383853127605 65772.17647433636 56151.82891721395 49869.665805020006 51180.43561940059 45587.00329891022 51154.06335586398 45524.08320494988 57098.529524219295 63957.47954776808 0.8062916834396608 1.0283734903157484 0.8779556248034398 0.7797315678735233 0.8002259623313538 0.7127704784686292 0.7998136217619148 0.7117866983946607 0.8927576559919622 1.0 15.964825465403594 -5.605509249581761 4.739472081115842 0.797030554610082 0.9254116753062187 0.14968863494409457 0.09488940127488489 0.2665319262462013 10.68926406605232 0.024299982867980387 0.043623718978781985 2.4802231134648596e-06 5.605509249581761 0.12838112069613672 AKSPT(ph)PESSTIASYVTLR ddPTM_A459_Selumetinib_30min_R1 1 AKSPTPESSTIASYVTLR 18 1 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 AKS(0.375)PT(0.622)PES(0.002)STIASYVTLR 85.054 0.010769 132200000.0 1395.3 1648.8 1369.2 1506.4 1456.5 1260.1 1202.0 875.11 677.89 847.9 True False 1427.807775218819 1455.7577294936757 1183.2701604772433 1243.3355186301537 1324.7598321659598 1247.424538079257 1111.3321722642486 851.8992400421065 1150.329818873325 956.736224245404 1.4923734871071261 1.5215873430964313 1.2367778395874065 1.299559363512964 1.3846656984382744 1.3038332891211728 1.1615868032390824 0.8904222694337884 1.202347930100182 1.0 9.9019774128899 -6.892755885272517 0.47722737072273697 0.9811852915124668 1.4913985501135363 0.6663932265165784 0.10929184259910153 0.6798924202386523 0.33142722493130633 0.10893414474598455 0.13642530199084343 1.2801006400538966e-07 6.892755885272517 0.5102132586010695 AKSPTPES(ph)STIASYVTLR ddPTM_A459_Selumetinib_30min_R2 1 AKSPTPESSTIASYVTLR 18 1 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 AKS(0.349)PT(0.134)PES(0.401)S(0.116)TIASYVTLR 88.637 0.0035343 61759000.0 18316.0 10555.0 19667.0 17133.0 13076.0 11958.0 15035.0 16775.0 11216.0 11587.0 True False 17298.070044757344 11364.534560325785 18401.646631810545 14799.455843926475 11433.275979076825 13605.105956083855 15734.157291287309 16823.812472749254 13459.513401224096 11252.453203358511 1.5372710050102143 1.0099606152491103 1.635345315305841 1.315220385854108 1.0160696314350672 1.2090790968162524 1.398286845271318 1.4951239670766072 1.1961403578383107 1.0 13.457951944413061 -8.532277568463261 22.604231745654264 0.9999999832052313 1.3163842833471562 0.2098850306151271 0.19615888973430848 561.0009358197832 1349214.6582638656 0.18787561927762658 0.048509276291757414 2.93577272646961e-09 8.532277568463261 0.31638430014192487 AKT(ph)PEPGAQQSGFPTLSR ddPTM_A459_Selumetinib_30min_R2 1 AKTPEPGAQQSGFPTLSR 18 1 Q9H9D4 Q9H9D4 ZNF408 Zinc finger protein 408 1 AKT(1)PEPGAQQSGFPTLSR 68.406 0.038231 16412000.0 17103.0 20695.0 21652.0 19923.0 16429.0 14356.0 18741.0 16649.0 18505.0 15275.0 True False 16152.48372873362 22282.239955086887 20258.93389291513 17209.45303090803 14365.042142876498 16333.408689207223 19612.493634587 16697.44583360968 22206.5170729005 14833.971060783737 1.088884673062064 1.5021089001578265 1.3657121083695016 1.160137967128998 0.9683881736059917 1.1010813370391102 1.3221337397937998 1.1256221119206826 1.497004206217404 1.0 13.856617239162587 -5.7656696003809715 24.771982710919186 1.1683469787083514 1.3372226080549106 0.13689048444767304 0.17206932419284238 170.3537345455854 997592.8180686547 0.04792791629671544 0.07404058125714176 1.7152617364826178e-06 5.7656696003809715 0.1688756293465592 AKT(ph)QTPPVS(ph)PAPQPTEER ddPTM_A459_Selumetinib_30min_R1 2 AKTQTPPVSPAPQPTEER 18 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.772)QT(0.238)PPVS(0.972)PAPQPT(0.018)EER;AKT(0.748)QT(0.252)PPVS(0.999)PAPQPT(0.001)EER 115.31 0.003590400000000001 26644000.0 13107.099999999999 22140.0 18638.800000000003 18824.0 19067.5 18576.800000000003 20662.0 19195.6 11131.099999999999 15506.5 True False 13412.469928023072 19547.83850739323 16107.753335599797 15536.741770242987 17342.84799164054 18389.93425838486 19103.44870492836 18686.47033190371 18888.663716621966 17496.91032110077 0.7665621919458556 1.1172165913097867 0.9206055834997513 0.8879705893849226 0.9911948837461643 1.0510389503572597 1.0918184041836316 1.0679868610498828 1.0795428089862689 1.0 14.094812566866384 -6.62918146276241 3.077199358110387 1.065437427673337 0.9367385914106022 0.3608246902253427 0.08349980926007206 0.29260698931646517 5.550869203991112 0.028368568879624006 0.028366521829514064 2.3486512707331596e-07 6.62918146276241 -0.1286988362627347 AKT(ph)QTPPVSPAPQPT(ph)EERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.54)QT(0.437)PPVS(0.023)PAPQPT(0.326)EERLPS(0.326)S(0.326)PVY(0.021)EDAAS(0.001)FK 61.911 0.00074782 8862500.0 57166.0 71797.0 66369.0 71740.0 59212.0 35002.0 23064.0 27940.0 15308.0 63634.0 True False 53988.94257362958 77303.59903625865 62098.89079710343 61968.88824159722 51773.25919800372 39823.20778347946 24136.52170044897 28021.300774284 18370.027741257003 61796.72107901227 0.8736538384391012 1.2509336690763826 1.0048897370736678 1.0027860242352473 0.837799454307734 0.6444226665774413 0.39057932652427324 0.45344316470215995 0.29726541182936533 1.0 15.915242670615257 -6.649113841026659 1.6937207918738089 0.48964661580870394 1.0546510913510792 0.5649916542240663 0.19698472615500906 0.23146919844907746 1.3682468091337847 0.07602323835769531 0.0755443460962811 2.2432938151246131e-07 6.649113841026659 0.5650044755423752 AKT(ph)QTPPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R1 3 AKTQTPPVSPAPQPTEER 18 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKT(0.941)QT(0.059)PPVSPAPQPTEER;AKT(0.595)QT(0.405)PPVSPAPQPTEER;AKT(0.974)QT(0.025)PPVS(0.001)PAPQPTEER 122.35 0.0012618 369500100.0 10439.599999999999 16419.5 12935.6 14673.0 13252.8 12456.0 14196.099999999999 13006.5 6509.0 12426.2 True False 10682.822368074523 14497.097306781543 11179.01657016465 12110.635996322524 12054.086579971876 12330.703949143119 13125.276747654312 12661.5253689338 11045.297601449307 14021.223811437956 0.761903704822107 1.0339395121098764 0.7972924988933743 0.8637360161416973 0.8597028862871893 0.8794313616964178 0.936100651709677 0.9030256944194153 0.7877556017926903 1.0 13.775324656832195 -7.013072598908417 23.07749206938608 0.8999431130982671 0.869191298243886 0.053552047398159 0.08237482461414623 1031.398342996761 1820760.3684132167 0.02921117468498319 0.023758670024381357 9.703477453466736e-08 7.013072598908417 -0.030751814854381165 AKT(ph)QTPPVSPAPQPTEERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKT(0.546)QT(0.45)PPVS(0.004)PAPQPTEERLPSSPVYEDAASFK 64.733 0.00035813 78000000.0 915.39 1107.6 1400.5 1772.3 1419.2 1352.4 1080.6 996.85 727.24 907.1 True False 936.7168059611225 977.9216770907298 1210.319792395836 1462.8010751913316 1290.833610580111 1338.7960838809533 999.0894720039486 970.4102997748548 1234.0731644919347 1023.5351209022359 0.9151779815190084 0.9554353896803284 1.18248975309118 1.429165492535212 1.2611522401324677 1.308011866462206 0.9761164532617711 0.9480967286393142 1.2056969412091219 1.0 9.999344891549224 -7.2804603784964605 24.49531534728054 1.0281522533746654 1.1810246038302374 0.16445330195722863 0.157200022608555 1316.410892506602 1695271.1681132575 0.07358980580715067 0.04971356488698082 5.24251427271881e-08 7.2804603784964605 0.15287235045557201 AKTPEPGAQQSGFPT(ph)LSR ddPTM_A459_Selumetinib_30min_R1 1 AKTPEPGAQQSGFPTLSR 18 1 Q9H9D4 Q9H9D4 ZNF408 Zinc finger protein 408 1 AKT(0.213)PEPGAQQS(0.213)GFPT(0.442)LS(0.132)R 119.21 0.010158 7265300.0 790.11 974.24 792.61 947.25 772.34 666.45 915.16 810.19 616.2 831.0 True False 808.5180257135679 860.1755278881116 684.9779154950832 781.8305695847147 702.4819833677021 659.7461180881846 846.1287444004568 788.7011293319861 1045.6463945326575 937.6669446254638 0.8622656800987238 0.9173572053685811 0.7305130242899698 0.8338041284978907 0.7491807057870612 0.7036038988787322 0.902376637302096 0.841131420759447 1.115157573300533 1.0 9.872931764261214 -8.184116004927143 5.144459266671196 1.0564004270030987 0.8133509932184637 0.6408603452034227 0.07192368184618689 0.1299147249764447 6.003611302099832 0.0538701451605437 0.01908939176879686 6.544613367543565e-09 8.184116004927143 -0.24304943378463495 AKTQT(ph)PPVS(ph)PAPQPTEER ddPTM_A459_Selumetinib_30min_R1 1 AKTQTPPVSPAPQPTEER 18 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.218)QT(0.786)PPVS(0.996)PAPQPT(0.001)EER 93.093 0.015984 24469000.0 2060.2 2717.0 2358.4 2776.6 3053.9 2591.3 2964.9 3052.5 1483.0 2036.2 True False 2108.198651548635 2398.892376900967 2038.1422337638987 2291.7189332371795 2777.6752842098363 2565.233874712151 2741.255205945317 2971.5377840826054 2516.5426859654835 2297.5661042675915 0.9175791058341183 1.0441015701115925 0.8870875270914607 0.9974550586294116 1.2089642509307874 1.1165005742152023 1.1931126598941373 1.2933415837582003 1.095308065909902 1.0 11.165890655176215 -6.1635344948106265 4.829169718930232 1.1659260423127427 0.9571751004616027 0.5575590515455673 0.08264865240957008 0.15621386697974865 5.920826585141282 0.02374545496511396 0.03098824172856949 6.862233714206576e-07 6.1635344948106265 -0.20875094185113996 AKTQT(ph)PPVS(ph)PAPQPTEER ddPTM_A459_Selumetinib_30min_R2 4 AKTQTPPVSPAPQPTEER 18 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.104)QT(0.896)PPVS(1)PAPQPTEER;AKT(0.271)QT(0.729)PPVS(0.997)PAPQPT(0.003)EER;AKT(0.465)QT(0.536)PPVS(0.999)PAPQPTEER;AKT(0.375)QT(0.625)PPVS(1)PAPQPTEER 134.42 0.0013049 180919000.0 200202.0 190917.0 202403.0 195882.0 210999.0 134725.0 169121.0 176627.0 142986.0 218334.0 True False 189075.57431210496 205559.72000508982 189380.61133972398 169202.53368470265 184491.4192650068 153282.14583821682 176985.46160690393 177140.955327826 171587.19536264526 212030.130120141 0.8917391797334205 0.9694835346684696 0.8931778291718102 0.7980117429010147 0.8701188796161653 0.7229262452056401 0.834718450187339 0.8354518069080747 0.8092585486101439 1.0 17.693909765103847 -5.576322982964768 5.068035434018972 0.8284963375968357 0.9311895085224664 0.22305782731187274 0.0683806090379234 0.22515715845486792 12.27058337675182 0.017502752745704505 0.031573392937515966 2.6526320770018813e-06 5.576322982964768 0.10269317092563068 AKTQT(ph)PPVS(ph)PAPQPTEERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 2 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.099)QT(0.898)PPVS(0.966)PAPQPT(0.01)EERLPS(0.011)S(0.011)PVY(0.005)EDAAS(0.001)FK;AKT(0.239)QT(0.771)PPVS(0.949)PAPQPT(0.021)EERLPS(0.006)S(0.006)PVY(0.006)EDAAS(0.002)FK 55.88399999999999 0.0017406 7638000.0 21799.0 26520.0 22424.0 24089.0 18757.1 11132.5 9510.6 10075.0 7613.700000000001 27752.0 True False 20587.498848311057 28553.998724759804 20981.264253405192 20808.036644157186 16400.665407398432 12665.90082422676 9952.861744896383 10104.316581993968 9136.652744552413 26950.727651644534 0.7638939888532029 1.059488971646279 0.7785045555949921 0.7720769885368004 0.6085425825746735 0.469965078046933 0.36929844245927285 0.37491813625957526 0.33901321191210565 1.0 14.718036604855515 -6.24054286225355 1.475069190207034 0.46106665029894084 0.8952260121585335 0.39251539752841524 0.19403302371973716 0.34337017711591 1.4952285889596522 0.06866883245894037 0.09639345075332532 5.747210945306916e-07 6.24054286225355 0.43415936185959264 AKTQT(ph)PPVSPAPQPT(ph)EERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.107)QT(0.891)PPVS(0.002)PAPQPT(0.407)EERLPS(0.292)S(0.292)PVY(0.008)EDAASFK 79.67 1.0411e-05 22868000.0 2165.3 2542.3 4670.3 4723.3 3915.5 2894.2 2622.7 2736.4 1342.9 1823.1 True False 2215.7472770596364 2244.6463341167964 4036.0989121215825 3898.464322321963 3561.34371633767 2865.086975723344 2424.8676274521163 2663.821782920114 2278.8032184646304 2057.1126434978128 1.0771151905867873 1.0911635496538055 1.9620213433032034 1.8951146572572743 1.731234177960297 1.392771069090165 1.178772409530764 1.2949323856134018 1.1077678345264876 1.0 11.006405079869722 -7.091310704532626 3.3645978415624924 1.1696921619427554 1.5679050090482218 0.30765865506447065 0.28443524834682515 0.37367898219809853 8.014204335657972 0.12962438142896204 0.0997251821822537 8.103810846419814e-08 7.091310704532626 0.39821284710546645 AKTQT(ph)PPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R1 1 AKTQTPPVSPAPQPTEER 18 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKT(0.475)QT(0.512)PPVS(0.012)PAPQPTEER 82.475 0.01324 8041700.0 1843.3 3233.6 2498.6 2644.3 2779.9 3118.0 2749.9 2684.6 1561.2 2581.9 True False 1886.2453035625676 2855.0086087401455 2159.3038438273747 2182.5226446586025 2528.458535831206 3086.6357509174886 2542.47282904281 2613.3956871902255 2649.24237446346 2913.312014835723 0.6474573591695876 0.9799872427674503 0.7411852327630395 0.7491551311855182 0.8678982968371761 1.0594937086035183 0.8727087301653738 0.8970531387924787 0.9093575837302982 1.0 11.508444506617613 -6.522175568545653 24.999698759006325 0.9396107499395545 0.7932237897345168 0.4183741182725609 0.09273595183608481 28.569859761762732 1015782.1027701031 0.02959698390053041 0.029937528379352842 3.00486130726934e-07 6.522175568545653 -0.14638696020503772 AKTQT(ph)PPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R2 5 AKTQTPPVSPAPQPTEER 18 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKT(0.011)QT(0.973)PPVS(0.016)PAPQPTEER;AKT(0.281)QT(0.71)PPVS(0.01)PAPQPTEER;AKT(0.065)QT(0.935)PPVSPAPQPTEER;AKT(0.157)QT(0.842)PPVS(0.001)PAPQPTEER;AKT(0.261)QT(0.715)PPVS(0.024)PAPQPTEER 130.98 0.00076851 436538900.0 123048.4 111865.5 122571.4 111438.0 111012.3 82260.6 90367.7 91961.9 72286.5 98707.2 True False 116209.86252977292 120445.22414572473 114685.28956964963 96259.95215872762 97065.94241144609 93591.25096262174 94569.97711020046 92229.49390388784 86745.81985356525 95857.26666389464 1.2123218883054616 1.2565059315538707 1.1964172728998406 1.004200886472644 1.0126091196798823 0.9763605224712044 0.9865707671573005 0.962154431413876 0.9049477715416511 1.0 16.54860018215325 -5.754309217328788 3.0293237448694463 0.9742541160708851 1.2354521482598964 0.9383470791007696 0.02880871100924729 0.05624668017133751 1.059767734358835 0.008747309798388609 0.015381294438438066 1.7607219673600664e-06 5.754309217328788 0.2611980321890113 AKTQT(ph)PPVSPAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 2 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.178)QT(0.434)PPVS(0.377)PAPQPT(0.346)EERLPS(0.462)S(0.166)PVY(0.03)EDAAS(0.006)FK;AKT(0.055)QT(0.937)PPVS(0.007)PAPQPT(0.009)EERLPS(0.483)S(0.483)PVY(0.025)EDAAS(0.001)FK 79.9 8.8042e-06 42972000.0 4343.6 4665.2 9223.8 10048.0 7066.1 5794.6 5018.2 4682.4 2957.58 3431.1000000000004 True False 4444.797428825676 4118.996215207362 7971.258622706693 8293.305424320099 6426.972502621284 5736.311585075844 4639.673133824003 4558.207541421257 5018.797246903434 3871.5151067441952 1.1480769947359424 1.0639235807273628 2.0589506699381666 2.142134331304333 1.660066492166199 1.4816709807184183 1.1984127675859184 1.1773704649843264 1.2963393163985513 1.0 11.918682556256535 -7.134744531408066 2.818868889300002 1.1773211044482537 1.6353878310121543 0.2975032382118421 0.32369260907106184 0.41293963061449035 6.329889468632324 0.1562772788806012 0.11568104465942348 7.332557353146745e-08 7.134744531408066 0.4580667265639007 AKTQT(ph)PPVSPAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 AKT(0.07)QT(0.786)PPVS(0.144)PAPQPT(0.011)EERLPS(0.473)S(0.473)PVY(0.038)EDAAS(0.006)FK 70.57 0.00011554 8774400.0 30535.0 37269.0 31716.0 38616.0 29136.0 22246.0 15013.0 11784.0 9420.7 32867.0 True False 28837.986941289902 40127.4124612773 29675.427089769844 33356.434183684396 25475.675200855156 25310.184570918347 15711.134247695125 11818.289489053775 11305.103236350917 31918.044311278532 0.9035010622846882 1.2572014773191449 0.929738263421226 1.0450651004296525 0.7981590273014657 0.7929741660887024 0.49223361226249857 0.37026985030150095 0.35419160165637575 1.0 14.962084636721963 -6.767610049740718 1.3401158536037243 0.5033629484565976 1.049207583447961 0.5198774177879455 0.19775227126471023 0.2952298518274098 1.11023648944221 0.09055605225119538 0.08130100389056479 1.707614957492262e-07 6.767610049740718 0.5458446349913635 AKTQT(ph)PPVSPAPQPTEERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKT(0.051)QT(0.818)PPVS(0.131)PAPQPT(0.001)EERLPSSPVYEDAASFK 72.60300000000002 8.0033e-05 83484000.0 1309.2 1571.1 4076.7 4356.5 2824.3 1923.3 1904.3 1575.6 1170.6 1324.1 True False 1339.7018127402553 1387.1548816154261 3523.1065317101793 3595.7190566332106 2568.8425636706647 1903.9533482166792 1760.6571178392749 1533.8099697299112 1986.4227027587276 1494.0611328262041 0.8966847361901726 0.9284458655258963 2.358073879511062 2.4066746518139164 1.719369112300898 1.2743476865736494 1.1784371329630743 1.0266045585621502 1.3295457991074031 1.0 10.545023465065547 -6.849964119454286 4.071358176804855 1.1477522401419284 1.7014922171795663 0.21910215960773982 0.4739757577010348 0.3896091860753761 12.110949578297712 0.19476857233629755 0.17291336444557456 1.412654250484238e-07 6.849964119454286 0.5537399770376379 AKTQT(ph)PPVSPAPQPTEERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKT(0.207)QT(0.759)PPVS(0.033)PAPQPTEERLPSSPVYEDAASFK 46.783 0.024214 6828700.0 13873.0 21605.0 20054.0 19583.0 14767.0 9711.5 6281.9 6277.3 3752.9 16291.0 True False 13101.994198019147 23262.03402897572 18763.747473144296 16915.761617440738 12911.837441345007 11049.170972780428 6574.020797348704 6295.5659037370415 4503.584864787258 15820.636500898725 0.8281584749940283 1.4703601860553632 1.1860298713062765 1.0692213057597146 0.8161389360416392 0.6984024297728323 0.41553453282206776 0.39793379383815614 0.28466521334533046 1.0 13.949520023495278 -6.546830887557913 1.41296314701147 0.4804616051163019 1.1897404423748674 0.5783183317235635 0.23364046562539423 0.25809126213654354 1.0629119980036752 0.09471877373446823 0.10308874781258393 2.8390243173419066e-07 6.546830887557913 0.7092788372585654 AKTQTPPVSPAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 1 AKTQTPPVSPAPQPTEERLPSSPVYEDAASFK 32 2 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 AKTQTPPVSPAPQPT(0.109)EERLPS(0.402)S(0.402)PVY(0.081)EDAAS(0.005)FK 88.191 8.8669e-08 45111000.0 1958.7 2239.8 9687.7 9539.9 5958.5 3883.4 3423.0 2871.7 2137.5 1601.3 True False 2004.3338990332545 1977.563174745229 8372.163550726993 7873.93555110184 5419.554727058617 3844.3365218450836 3164.8003541268918 2795.5331874037734 3627.1813831768177 1806.842452982857 1.1093019735751535 1.0944856711112443 4.633588023629654 4.357842897759579 2.999461695241692 2.1276545254394454 1.75156408844735 1.5471925528364243 2.007469648053057 1.0 10.819255001042027 -6.959101321331744 3.0622391332420253 1.6352441200560088 2.922354083973888 0.22280820989095285 1.1046087138011755 0.4560549099234978 8.758968929647427 0.48559845864596574 0.4043207707954468 1.098749470191042e-07 6.959101321331744 1.2871099639178794 AKVPAQANGT(ph)PTTK ddPTM_A459_Selumetinib_30min_R2 1 AKVPAQANGTPTTK 14 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 AKVPAQANGT(0.584)PT(0.321)T(0.094)K 112.91 0.004792 19240000.0 57475.0 48638.0 59371.0 84149.0 78483.0 80517.0 71177.0 77239.0 66754.0 86801.0 True False 54280.76959065457 52368.37820418052 55551.1344982572 72687.76103487835 68623.26389307785 91607.48588944676 74486.8715345499 77463.75270239511 80106.66526259933 84294.82959391754 0.6439394901460398 0.6212525543554721 0.6590099863285754 0.8623039086150934 0.8140862757972701 1.0867509470124948 0.8836469792202372 0.9189620890814952 0.950315288001716 1.0 16.363156522603205 -5.9209448669387355 1.4279486946768294 0.9514597064684459 0.619099435161909 0.8115490934515643 0.06538354496031643 0.16917197835222136 0.7005399663573716 0.022106449627751983 0.04294784718675863 1.199651587530568e-06 5.9209448669387355 -0.3323602713065369 AKY(ph)EALAK ddPTM_A459_Selumetinib_30min_R1 1 AKYEALAK 8 1 Q8WW32 Q8WW32 HMGB4 High mobility group protein B4 1 AKY(1)EALAK 147.29 0.015739 14942000.0 4466.1 5038.2 6038.3 6306.2 5497.2 4793.6 4714.9 4477.8 2668.5 4098.9 True False 4570.151440482168 4448.325201804361 5218.3320260077 5204.94055203497 4999.979230609489 4745.3807362405605 4359.251297012234 4359.034198055723 4528.249600471268 4625.033741667043 0.9881336430715222 0.9617930268766021 1.1282797742631838 1.1253843415548588 1.0810687034701072 1.0260207819651799 0.9425339447233935 0.9424870047509225 0.9790738518675348 1.0 12.175248175427933 -7.084892407972735 4.123709268621504 0.9618582481091545 1.0591630781228971 0.40560739801551704 0.05172969344904948 0.25274162875987083 7.8303783398602995 0.02286901377545705 0.017749698697000715 8.224463774098216e-08 7.084892407972735 0.09730483001374257 ALAAAGYDVEK ddPTM_A459_Selumetinib_30min_R1 2 ALAAAGYDVEK 11 0 P10412;P22492;Q02539;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1T;HIST1H1A;HIST1H1D;HIST1H1C Histone H1.4;Histone H1t;Histone H1.1;Histone H1.3;Histone H1.2 0 ; 179.8 0.00071138 22481900.0 7605.8 6032.3 3573.8999999999996 5552.9 12490.6 8277.9 3751.3 3417.5 6691.6 12748.9 False True 7783.000341689452 5326.035511659816 3088.5840100274745 4583.190255842662 11360.827435394547 8194.63184173184 3468.336420811045 3326.856798395515 11355.15646487298 14385.345499802135 0.5410367336534604 0.37024036104889335 0.21470349878422848 0.3186013332739003 0.7897500574839034 0.5696513748553731 0.24110205909609544 0.2312670765148654 0.7893558389007178 1.0 13.812312250947494 -8.460814740550678 4.559269358541714 0.9971388852268013 0.412689646118939 0.5717780075876207 0.17241173359940695 0.14565234384176085 5.873806160263166 0.18098598988921363 0.04723816429412699 3.460869786190282e-09 8.460814740550678 -0.5844492391078623 ALAAAGYDVEK ddPTM_A459_Selumetinib_30min_R2 1 ALAAAGYDVEK 11 0 P10412;P22492;Q02539;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1T;HIST1H1A;HIST1H1D;HIST1H1C Histone H1.4;Histone H1t;Histone H1.1;Histone H1.3;Histone H1.2 0 179.8 0.00071138 5565500.0 87996.0 79373.0 79527.0 78421.0 71853.0 52288.0 56973.0 56243.0 51920.0 79475.0 False True 83105.534595898 85460.65387557917 74410.31940245075 67739.92451622951 62826.183766029935 59490.197376794844 59622.35738985777 56406.65781847011 62305.45076600881 77180.35024915157 1.0767706330383175 1.107285126326809 0.9641096362252999 0.8776835593198693 0.8140178628785191 0.7707946023145809 0.7725069554282463 0.7308422109562813 0.8072708994566105 1.0 16.235945970481836 -5.648698075061971 1.4953520795870372 0.797106699725377 1.1038102783729058 0.7034329092272018 0.07011300142704732 0.20530438538816842 0.9031916703963127 0.021293039250993923 0.05681989350472827 2.2454424305118977e-06 5.648698075061971 0.30670357864752884 ALAAGADS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ALAAGADSPK 10 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 ALAAGADS(1)PK;ALAAGADS(1)PK 127.17 0.003331800000000001 73416000.0 12276.599999999999 16630.9 13146.4 12767.1 10111.9 11830.5 12979.1 12474.0 8582.900000000001 14135.400000000001 True False 12562.620893894764 14683.746496504347 11361.191088006166 10537.565653148587 9197.28043040095 11711.495911234553 12000.076037466637 12143.14899873757 14564.554429786345 15949.816280455818 0.7876342067518627 0.9206216697616226 0.7123085863959232 0.6606700333006872 0.5766386438990448 0.7342715242171968 0.7523645305037768 0.7613347254424011 0.9131487268372546 1.0 13.961252185809073 -8.365411215704102 2.0195689023371433 1.0002460818141294 0.7317245521055956 0.5399716861868187 0.08287642339142118 0.2697520584746556 2.190117989804426 0.088833374456497 0.02530788431234265 4.311106824178589e-09 8.365411215704102 -0.2685215297085338 ALAAGADS(ph)PKTEEARPSPAPGPGTPTGTPTR ddPTM_A459_Selumetinib_30min_R1 2 ALAAGADSPKTEEARPSPAPGPGTPTGTPTR 31 2 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 ALAAGADS(0.917)PKT(0.082)EEARPSPAPGPGTPTGTPTR;ALAAGADS(0.633)PKT(0.233)EEARPS(0.015)PAPGPGT(0.066)PT(0.015)GT(0.019)PT(0.019)R 68.153 0.00010734 67052000.0 1789.56 1906.4 4523.5 4611.9 2618.23 2894.2 1804.77 2014.19 1481.0 1806.6999999999998 True False 1831.2532661224031 1683.1978017386848 3909.233545806901 3806.518241084978 2381.4115587860506 2865.086975723344 1668.634745871337 1960.7671381888115 2513.148832039703 2038.6075437482848 0.8982863188838055 0.8256605381945531 1.9175998626097452 1.8672148313971826 1.1681559631666374 1.4054137023624729 0.8185169092444848 0.9618168755442001 1.2327771668199083 1.0 10.99336835075508 -7.24685051423962 24.269144271011093 1.0000958117707124 1.3648011530312667 0.19074097330775064 0.34571811843450084 987.0764870701149 1642041.987234141 0.1459538837488004 0.11250452615867519 5.6643422423404495e-08 7.24685051423962 0.3647053412605543 ALAAGADS(ph)PKTEEARPSPAPGPGTPTGTPTR ddPTM_A459_Selumetinib_30min_R2 2 ALAAGADSPKTEEARPSPAPGPGTPTGTPTR 31 2 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 ALAAGADS(0.742)PKT(0.192)EEARPS(0.064)PAPGPGT(0.001)PTGTPTR;ALAAGADS(0.856)PKT(0.119)EEARPS(0.02)PAPGPGT(0.002)PT(0.001)GT(0.001)PT(0.001)R 51.858 0.0040149 37660000.0 42107.0 44900.0 37845.0 37140.0 29229.8 23845.0 20372.1 14498.8 14783.0 39372.0 True False 39766.86150767623 48343.68562374493 35410.093902520486 32081.467929926424 25557.691206272524 27129.432306641567 21319.44301655032 14540.989107594456 17740.01307153136 38235.22805925878 1.0400581747817392 1.2643755007507627 0.9261117482453678 0.8390552262485538 0.6684330786954376 0.7095402246481983 0.5575863960719271 0.3803034490877925 0.46397037423281595 1.0 15.22261485880871 -5.893250580638323 1.0214542651188738 0.5695725608550374 1.178001640179312 0.5920703641310057 0.16919396151634994 0.3703284733270745 0.7658462147921361 0.06681821254712932 0.1635011557023349 1.2786433355026375e-06 5.893250580638323 0.6084290793242747 ALAEEAS(ph)EEELPS(ph)DVDLNDPYFAEEVK ddPTM_A459_Selumetinib_30min_R1 1 ALAEEASEEELPSDVDLNDPYFAEEVK 27 0 Q9H501 Q9H501 ESF1 ESF1 homolog 2 ALAEEAS(1)EEELPS(0.827)DVDLNDPY(0.173)FAEEVK 71.44 0.0020050000000000003 2024400.0 452.6 461.64 595.47 559.82 302.16 342.18 466.1 327.58 304.16 250.32 True False 463.14469939370593 407.5909741893863 514.6084446825771 462.0579461228974 274.8296813506807 338.7379798745816 430.94170174073696 318.89151427019806 516.1373050325429 282.4510103232803 1.639734617566466 1.4430501548671277 1.8219387641544642 1.6358870361060043 0.9730171651222752 1.1992804680956102 1.5257219340355737 1.1290153074871627 1.8273515978639843 1.0 8.141856850957065 -6.20074184808011 22.82498356570883 1.2908588159824 1.634774162044497 0.3270929126602462 0.2519924260330016 121.50395326474013 45690.18455270208 0.0725087257586165 0.09360832602061125 6.298804831185179e-07 6.20074184808011 0.34391534606209717 ALAEEASEEELPS(ph)DVDLNDPYFAEEVK ddPTM_A459_Selumetinib_30min_R1 3 ALAEEASEEELPSDVDLNDPYFAEEVK 27 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 ALAEEASEEELPS(1)DVDLNDPYFAEEVK;ALAEEAS(0.002)EEELPS(0.998)DVDLNDPYFAEEVK;ALAEEASEEELPS(1)DVDLNDPYFAEEVK 183.64 7.7991e-27 22606000.0 5451.95 6192.959999999999 7013.700000000001 7715.099999999999 6562.46 5345.77 5631.089999999999 5686.13 3483.35 4930.79 True False 5578.969827352 5467.885364171004 6061.278063496379 6367.802615363454 5968.886651696418 5291.9964073708115 5206.332347683433 5535.315361246725 5910.990536181973 5563.704926461843 1.002743657525322 0.9827777418901017 1.0894319780813684 1.1445255813400883 1.0728258832181174 0.951164103294058 0.9357671581253905 0.9948973632515822 1.0624198469024455 1.0 12.441830192605032 -6.750994421497326 24.91650426873212 0.9852131196954163 1.0607583352142178 0.3056588027360936 0.052258005652227504 270.6559905997963 645650.4893088262 0.019481593764901568 0.01928311035117017 1.7742122704597802e-07 6.750994421497326 0.07554521551880156 ALAEEASEEELPS(ph)DVDLNDPYFAEEVK ddPTM_A459_Selumetinib_30min_R2 3 ALAEEASEEELPSDVDLNDPYFAEEVK 27 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 ALAEEAS(0.341)EEELPS(0.659)DVDLNDPYFAEEVK;ALAEEAS(0.07)EEELPS(0.93)DVDLNDPYFAEEVK;ALAEEAS(0.013)EEELPS(0.987)DVDLNDPYFAEEVK 120.63 1.582e-09 4379100.0 41345.1 40067.0 40864.3 40264.9 40950.5 28478.2 32254.8 31342.5 28474.0 38703.0 True False 39047.304859548894 43140.01006428924 38235.135427685775 34780.75115917327 35805.93208788506 32400.81355063951 33754.71211167369 31433.701485969796 34169.59563003343 37585.54382752951 1.0388915759401283 1.1477819840055465 1.0172830171923832 0.925375759328461 0.9526516964125721 0.8620552013114029 0.8980769911582355 0.8363242429113451 0.9091153712403099 1.0 15.197890257978607 -5.6658541185195315 2.206321551710639 0.900180986742589 1.0952787696265693 0.6843207620241625 0.04991245405755806 0.15567873884331726 1.5328860427173592 0.014262319112086204 0.029774803928842342 2.158469327002381e-06 5.6658541185195315 0.1950977828839804 ALAGCDFLT(ph)ISPK ddPTM_A459_Selumetinib_30min_R2 1 ALAGCDFLTISPK 13 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 ALAGCDFLT(0.793)IS(0.207)PK 148.68 0.00092746 0.0 10779.0 11219.0 9954.1 12885.0 9712.9 9351.4 9880.4 9060.9 7921.2 10902.0 True False 10179.946331755818 12079.461225229283 9313.66404320462 11130.040772135219 8492.678667572289 10639.470466442768 10339.858177641183 9087.265718887256 9505.66133682028 10587.230933202252 0.9615305830187229 1.140946230552816 0.8797072720872043 1.0512702369824274 0.8021624087691042 1.0049342017351004 0.9766348011938332 0.8583231797078302 0.8978420700175624 1.0 13.370037684524405 -5.272690512321278 24.89414104786158 0.9323552622636033 1.0512384143468274 0.24349315218742373 0.08272476025902076 800.4757149450772 1771126.0774331316 0.020524650174398164 0.043399089147319755 5.33715096969601e-06 5.272690512321278 0.11888315208322409 ALAGCDFLTIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ALAGCDFLTISPK 13 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 ALAGCDFLT(0.036)IS(0.964)PK 124.48 0.0018866 0.0 11450.0 10359.0 10308.0 9087.5 10824.0 8133.7 9642.4 7670.1 5648.3 9465.7 True False 10813.654837981641 11153.501990565113 9644.794502501805 7849.766823188111 9464.192352212252 9254.043344622787 10090.790706053129 7692.4187211465905 6778.117826688125 9192.400646157816 1.1763689654346678 1.21333941153087 1.049213896756456 0.8539408937173674 1.02956699958112 1.006705832441141 1.097731821585781 0.8368237000594422 0.7373610102080572 1.0 13.166225963154023 -3.7029935415035315 0.40976446212113893 0.9059090187243688 1.902188248757791 0.444112548034184 0.10712781592554226 12.921705452768707 0.8584571412095708 0.08562639862454426 7.548408993961751 0.00019815564937836032 3.7029935415035315 0.9962792300334222 ALAMPGRPES(ph)PPVFR ddPTM_A459_Selumetinib_30min_R1 1 ALAMPGRPESPPVFR 15 1 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ERU2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 ALAMPGRPES(1)PPVFR 67.118 0.033669 327430000.0 1880.0 2250.0 2360.0 2382.4 2252.3 1843.7 1798.6 1711.9 1064.9 1772.7 True False 1923.8003421567976 1986.568954003378 2039.5249625520712 1966.3585631867218 2048.5798626758615 1825.1540519456623 1662.9301539388332 1666.4948509651144 1807.0575227812824 2000.2433125602408 0.96178316411637 0.9931636524061864 1.0196384358568615 0.9830596862088004 1.0241653351930229 0.9124660187512535 0.831363936325497 0.8331460680311236 0.9034188548133739 1.0 10.965959786898852 -6.904752629624862 4.830820418494591 0.8772466211122881 0.9962723666611539 0.5196395272842922 0.04757077539102107 0.14579559899679245 5.770688369264148 0.016501170475492776 0.014478245592467747 1.2452236784345094e-07 6.904752629624862 0.1190257455488658 ALAMPGRPES(ph)PPVFR ddPTM_A459_Selumetinib_30min_R2 4 ALAMPGRPESPPVFR 15 1 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ERU2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 ALAMPGRPES(1)PPVFR;ALAMPGRPES(1)PPVFR;ALAMPGRPES(1)PPVFR;ALAMPGRPES(1)PPVFR 106.87 0.0024086 299889000.0 173186.0 153564.0 177547.0 192604.0 192808.0 148932.0 133343.0 148923.0 136431.0 186713.0 True False 163561.015438488 165341.86501391488 166123.8193185571 166371.00293956813 168585.73531461027 169446.03112991154 139543.71371414184 149356.3412744703 163721.01220064264 181322.1105513659 0.9020467219421292 0.9118681914254243 0.9161807063319872 0.9175439356715278 0.9297582892785289 0.9345028613149192 0.7695901690633098 0.8237072733176676 0.9029291116389409 1.0 17.468195333539 ALANS(ph)LACQGK ddPTM_A459_Selumetinib_30min_R2 2 ALANSLACQGK 11 0 P04075;P04075-2;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 ALANS(1)LACQGK;ALANS(1)LACQGK 125.61 0.0033166 29575000.0 101402.0 96522.0 102160.0 88651.0 117635.0 82528.0 80514.0 95156.0 82908.0 96374.0 True False 95766.48278436813 103924.92703285342 95587.13682339767 76576.58086849515 102856.639629757 93895.48288540632 84258.06053546435 95432.8882060761 99491.9166430712 93591.4322102766 1.0232398470963104 1.1104106922881576 1.021323582362082 0.8182007589802309 1.0989963205036097 1.0032487020227085 0.9002753622378329 1.0196754761874165 1.06304513451122 1.0 16.514088844470244 -5.519740997004897 24.99870525567618 0.983540218995528 1.0665857564001933 0.14749839560236566 0.077256659739435 213.82232528191906 1703533.7500919558 0.02086441989045828 0.03707160386338842 3.0217532855967265e-06 5.519740997004897 0.08304553740466525 ALANSLACQGK ddPTM_A459_Selumetinib_30min_R1 1 ALANSLACQGK 11 0 P04075;P04075-2;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 175.65 0.001037 14761000.0 2896.5 2851.4 3028.1 3542.0 2863.7 2529.4 2782.4 2937.0 2193.6 2603.6 False True 2963.98281439211 2517.556762420102 2616.90065216268 2923.4561915746185 2604.6788406272976 2503.9565325114486 2572.521327876909 2859.10121927948 3722.37898579493 2937.7974212116205 1.0089132739348958 0.8569538335906767 0.8907696062594423 0.995118373536087 0.8866094107853983 0.8523244368152365 0.8756632806954869 0.9732125158242926 1.2670645562278862 1.0 11.520519201492402 -8.057507163707387 6.616356486467395 1.1323088909419257 0.9079787713855128 0.5617539326605157 0.07810184147178469 0.16148640637555609 14.898048281359271 0.04996915683904236 0.018874608000602172 8.759772682287526e-09 8.057507163707387 -0.2243301195564129 ALANSLACQGK ddPTM_A459_Selumetinib_30min_R2 2 ALANSLACQGK 11 0 P04075;P04075-2;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 147.74 0.009156999999999998 18227800.0 58418.0 58763.0 98988.0 136246.0 149538.0 102102.0 63481.0 81540.0 98714.0 84571.0 False True 55171.36142578266 63269.93314717426 92619.2198499853 117689.05976254039 130751.69955331838 116165.62371032572 66432.99228521516 81777.26790032625 118459.55829961108 82129.21548815313 0.6717629177127712 0.770370601632019 1.1277256126152249 1.4329743570911944 1.5920242118004753 1.4144250985458666 0.8088838045067885 0.9957147090017235 1.4423558972957495 1.0 16.32560789682944 -5.284586669109728 3.1955495287858047 1.246379821864332 0.6951629282818785 0.4388224584089353 0.23221444936701696 0.24638508748744892 5.134356873874264 0.06892424529241964 0.1894338381894124 5.192940312909667e-06 5.284586669109728 -0.5512168935824535 ALAPS(ph)PPAEFIYYCVDEDELKR ddPTM_A459_Selumetinib_30min_R1 2 ALAPSPPAEFIYYCVDEDELKR 22 1 K7EN65;K7EPZ6;A0A0A0MS90;Q9UIS9-4;Q9UIS9-11;Q9UIS9-7 K7EN65 MBD1 Methyl-CpG-binding domain protein 1 1 ALAPS(1)PPAEFIYYCVDEDELKR;ALAPS(1)PPAEFIYYCVDEDELKR 128.72 1.3698e-05 10690200.0 4336.2 1223.67 2529.5 1463.18 2791.5 1220.75 1850.5300000000002 2906.3999999999996 2964.6000000000004 3094.2 True False 4437.225023223567 1080.40214753125 2186.0077935489235 1207.6630802902735 2539.0093178793527 1208.470363352317 1710.9430322297503 2829.3128306822873 5030.709674182923 3491.3707100602983 1.2709120261672051 0.3094492785936761 0.6261173547827494 0.3458994133193654 0.7272242132762529 0.3461306357042349 0.49004908796986535 0.810373078553272 1.4408981720809702 1.0 11.76957783352388 -8.044714074867324 4.47153642953888 1.211173567138215 0.5684530757300422 0.43950758006748725 0.2818186790782753 0.18037510269002102 7.838530021660616 0.18532179598468204 0.06929624226747079 9.021648976789757e-09 8.044714074867324 -0.6427204914081727 ALAS(ph)VGPEEAR ddPTM_A459_Selumetinib_30min_R1 1 ALASVGPEEAR 11 0 P27987-2;P27987 P27987-2 ITPKB Inositol-trisphosphate 3-kinase B 1 ALAS(1)VGPEEAR 100.02 0.016682 13175000.0 2167.5 2443.8 2481.2 2616.4 2540.5 2011.2 2373.0 1837.5 1112.8 1713.2 True False 2217.9985327791815 2157.678759908203 2144.2666682560157 2159.494855910739 2310.7122235617053 1990.969154023494 2194.002699486739 1788.7635309588165 1888.3403243037026 1933.1059079811607 1.1473755905570369 1.1161720374449504 1.1092339325036675 1.1171115079597513 1.1953365896930592 1.0299327863017929 1.134962492447217 0.9253313662606887 0.9768426636675023 1.0 10.91670496449455 -7.756310990494496 24.99990641092841 0.9633152480098058 1.11992930946635 0.7357880789705951 0.042276387009961135 58.96995151510431 287471.24825358606 0.020018963804972794 0.011103263998645285 1.752625029014179e-08 7.756310990494496 0.15661406145654422 ALASNTSFFSGCS(ph)PIEEEAH ddPTM_A459_Selumetinib_30min_R1 3 ALASNTSFFSGCSPIEEEAH 20 0 O95239;Q2VIQ3 O95239 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 1 ALASNTSFFSGCS(1)PIEEEAH;ALASNTSFFS(0.001)GCS(0.999)PIEEEAH;ALASNTSFFS(0.002)GCS(0.998)PIEEEAH 191.44 1.2709000000000004e-15 104445300.0 6287.5 7085.200000000001 8425.3 8995.1 8631.8 7479.299999999999 7664.4 7501.799999999999 3906.8 6030.9 True False 6433.986516654717 6255.661490179886 7281.190536860151 7424.27464393926 7851.05521406807 7404.065032661052 7086.268137356156 7302.827894719377 6629.554258617634 6805.024760940685 0.9454758421430522 0.9192709372765223 1.069972673523916 1.0909989169404541 1.1537144227793799 1.0880291097776342 1.0413287807606146 1.073152288384896 0.9742145681335045 1.0 12.732384695828733 -5.264487242233278 24.643837040227492 1.0686234257081886 0.9323733803044572 0.5344561833623582 0.04780230787235313 147.77623222213586 1194876.6630804283 0.012878903257946066 0.02881476160773084 5.438921087751915e-06 5.264487242233278 -0.13625004540373142 ALASNTSFFSGCS(ph)PIEEEAH ddPTM_A459_Selumetinib_30min_R2 4 ALASNTSFFSGCSPIEEEAH 20 0 O95239;Q2VIQ3 O95239 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 1 ALASNTSFFS(0.11)GCS(0.89)PIEEEAH;ALASNTSFFS(0.004)GCS(0.996)PIEEEAH;ALASNTSFFS(0.007)GCS(0.993)PIEEEAH;ALASNTSFFS(0.077)GCS(0.923)PIEEEAH 187.31 1.2918e-15 34936600.0 107529.0 103902.4 115171.0 108010.0 109274.0 90779.0 91630.5 93822.0 76323.0 101847.0 True False 101552.96865269246 111871.37998112684 107761.02324870376 93298.85167235727 95546.02319804518 103282.98324028567 95891.49981239128 94095.00648693187 91589.7326427984 98906.41247971449 1.0267581859115633 1.1310831843594715 1.0895251434865796 0.9433043756540324 0.9660245559674049 1.04424961588278 0.9695175207376816 0.9513539529727718 0.9260242116413157 1.0 16.593776438984598 -5.75323896383939 24.999605554811282 0.9721903465381772 1.0873183131031219 0.632199448845008 0.038728169556972676 114.78016508750197 349912.5736330625 0.01083360420740994 0.018359072688991382 1.7650663529097123e-06 5.75323896383939 0.11512796656494473 ALDEGDIALLK ddPTM_A459_Selumetinib_30min_R2 1 ALDEGDIALLK 11 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 140.45 0.015035 937460.0 13125.0 9914.8 11007.0 12068.0 15559.0 7973.2 6747.4 10367.0 8201.3 9020.9 False True 12395.56504353791 10675.233278893238 10298.82160351547 10424.317581538831 13604.339320775176 9071.435926496726 7061.167469719451 10397.166253650754 9841.789163468182 8760.443177887004 1.4149472568724186 1.2185722870550113 1.175605091476607 1.1899303916326696 1.552928207458165 1.035499659354532 0.8060285680002077 1.1868310817762215 1.1234350778406619 1.0 13.096788140146884 -6.94079130074811 24.92501826748169 1.0269455603612143 1.2914251428787085 0.49642207058672716 0.1403811100405651 68.50256903702613 28836.98362101085 0.050856189069321114 0.04485093850018219 1.1460635474393995e-07 6.94079130074811 0.26447958251749415 ALDIDS(ph)DEESEPK ddPTM_A459_Selumetinib_30min_R1 5 ALDIDSDEESEPK 13 0 Q96DR7;Q96DR7-4;Q96DR7-3 Q96DR7 ARHGEF26 Rho guanine nucleotide exchange factor 26 1 ALDIDS(1)DEESEPK;ALDIDS(1)DEESEPK;ALDIDS(1)DEESEPK;ALDIDS(1)DEESEPK;ALDIDS(0.897)DEES(0.103)EPK 241.76 2.1456999999999998e-64 12913000.0 7193.2 8712.26 7188.6900000000005 7939.29 7171.24 6654.98 6926.89 6758.780000000001 4142.18 6473.39 True False 7360.7875644692995 7692.224548980214 6212.505382647647 6552.842040430959 6522.602608185253 6588.036943438376 6404.389110428864 6579.515198788482 7028.976927142622 7304.31266265828 1.0077317202068492 1.0531072400973538 0.8505256647087054 0.89711959811509 0.8929796559135057 0.901937971127426 0.8767955872384707 0.9007712980887075 0.9623050452203049 1.0 12.834532806174284 -5.252740973789857 24.999664159437014 0.9041753057011874 1.030419492761043 0.5668396189512865 0.04172596814683076 403.2551282496862 1158969.634281239 0.010076607797941116 0.025802319074045343 5.588033824054062e-06 5.252740973789857 0.12624418705985563 ALDIDS(ph)DEESEPK ddPTM_A459_Selumetinib_30min_R2 2 ALDIDSDEESEPK 13 0 Q96DR7;Q96DR7-4;Q96DR7-3 Q96DR7 ARHGEF26 Rho guanine nucleotide exchange factor 26 1 ALDIDS(1)DEESEPK;ALDIDS(1)DEESEPK 223.39 5.6707e-09 18069300.0 85280.0 71127.0 72283.0 80961.0 66674.0 59227.0 79566.0 76455.0 55269.0 65276.0 True False 80540.47900288858 76582.21219064831 67632.39047577967 69933.97213448495 58297.816046877335 67384.98164082434 83265.97665703805 76677.47139219331 66324.34434488724 63391.3122725839 1.2705286594567238 1.208086872556657 1.0669031457332678 1.1032106707898315 0.9196499324102264 1.0630002633652318 1.3135234730430045 1.2095895895399462 1.0462686757404744 1.0 15.951997513288106 -1.5228787760114866 0.0119121673498413 1.5788994384793715e-08 2.423944910827143 0.1187636801455979 0.1119515446383181 29115.171312873772 26.90143643577177 2292.7754591229154 3259.842845335195 0.029999997877167506 1.5228787760114866 2.4239448950381486 ALDQASEEIWNDFR ddPTM_A459_Selumetinib_30min_R1 1 ALDQASEEIWNDFR 14 0 P50579-3;P50579;G3V1U3;F8VQZ7;F8VY03;F8VRR3;P50579-2;F8VZX9 P50579-3 METAP2 Methionine aminopeptidase 2 0 140.01 0.0078395 1694500.0 301.2 538.25 575.71 442.56 471.6 481.48 482.72 531.64 303.96 389.32 False True 308.2173739668233 475.2314397743636 497.53174414866646 365.27520388008566 428.9438632677426 476.63674834886217 446.30804175989834 517.539180189902 515.797919639965 439.29301429793657 0.7016213869446707 1.0818096903586383 1.1325737672924416 0.8315069714091773 0.9764413485000811 1.0850087136272974 1.0159689028362378 1.1781183932938608 1.1741546140092758 1.0 8.77903974743928 -7.003104433663941 1.5109223089181172 1.117060331524649 0.9555115334057152 0.24283447352746734 0.12568832220231024 0.6199627089846904 2.8682624446507514 0.06420922100676374 0.047575645214209455 9.928772651000123e-08 7.003104433663941 -0.16154879811893386 ALDSEVDPDPEGDLGMPAQPHS(ph)PTGEAQHR ddPTM_A459_Selumetinib_30min_R2 1 ALDSEVDPDPEGDLGMPAQPHSPTGEAQHR 30 0 Q6IA17-2;C9JFX4 Q6IA17-2 SIGIRR 1 ALDSEVDPDPEGDLGMPAQPHS(0.828)PT(0.172)GEAQHR 100.27 3.0554000000000003e-08 4668400.0 14507.0 13479.0 15806.0 15805.0 16939.0 12656.0 13351.0 14162.0 15145.0 18832.0 True False 13700.759016122243 14512.795958183919 14789.059168271597 13652.331734854262 14810.971383418651 14399.249120270724 13971.847954504614 14203.209075354685 18174.42318665646 18288.27122858786 0.7491555021726434 0.7935575635764744 0.808663595559193 0.7465075055051246 0.8098617522834218 0.7873488390615132 0.763978605734155 0.7766293980347642 0.9937748056933104 1.0 14.158631084607578 -8.262646328050847 23.46481778434941 0.9968874925188561 0.7805675291295288 0.9459748022171048 0.020782555568880375 8.886074755301365 172732.27642569938 0.01633529096732275 0.005126085111509852 5.462024853483964e-09 8.262646328050847 -0.21631996338932735 ALDSNS(ph)LENDDLSAPGR ddPTM_A459_Selumetinib_30min_R1 2 ALDSNSLENDDLSAPGR 17 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 ALDS(0.292)NS(0.708)LENDDLSAPGR;ALDS(0.001)NS(0.999)LENDDLSAPGR 209.73 3.8701e-09 11456700.0 3267.4 4209.6 2402.0 2759.87 3030.0 2686.81 3680.8999999999996 3187.9 1823.6599999999999 3252.16 True False 3343.524062746341 3716.738075010053 2075.8215932415574 2277.9105136761846 2755.937034989949 2659.783130828291 3403.246749490409 3103.34653624142 3094.6178251435026 3669.6064147209945 0.9111396931653102 1.01284379166659 0.5656796284512122 0.6207506354191332 0.7510170638284888 0.7248142798525488 0.9274146502027965 0.8456892062843671 0.8433105557939763 1.0 11.84140961912562 -8.346695005304001 0.7541446572111064 0.9870769254914064 0.7676130902975165 0.20757291603696015 0.12864119558512632 1.1389640536034786 1.4590465294977437 0.1368208116924918 0.05386952516198116 4.500958355386754e-09 8.346695005304001 -0.2194638351938899 ALDSNS(ph)LENDDLSAPGR ddPTM_A459_Selumetinib_30min_R2 1 ALDSNSLENDDLSAPGR 17 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 ALDS(0.006)NS(0.985)LENDDLS(0.009)APGR 172.99 4.681300000000001e-07 7685100.0 14766.0 10460.0 12438.0 12917.0 14840.0 12364.0 13285.0 14081.0 10930.0 12130.0 True False 13945.364832981391 11262.24836579893 11637.752621470463 11157.682316932143 12975.666528716736 14067.028770782808 13902.778823728087 14121.973378764966 13116.30540971642 11779.77538247508 1.183839621740843 0.9560664783603531 0.9879435085650354 0.9471897344945616 1.1015207087921897 1.1941678269783058 1.1802244416656218 1.19883214409796 1.1134597209068786 1.0 13.524024409577006 -6.480604821594501 5.944781454004755 1.1522439608615946 1.0127181463250172 0.31131738040795864 0.08174870099783123 0.2076071653784072 19.338092382674056 0.025185861600328523 0.02795557480440056 3.306702916333647e-07 6.480604821594501 -0.13952581453657742 ALDSNS(ph)LENDDLSAPGREPGHFNPESR ddPTM_A459_Selumetinib_30min_R1 2 ALDSNSLENDDLSAPGREPGHFNPESR 27 1 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 ALDS(0.208)NS(0.792)LENDDLSAPGREPGHFNPESR;ALDS(0.075)NS(0.925)LENDDLSAPGREPGHFNPESR 113.75 1.0066e-10 43617000.0 2409.33 2861.93 2498.1 2657.37 2666.69 2221.5299999999997 2440.76 3093.9 1113.8999999999999 1862.85 True False 2465.462701259914 2526.8539051248385 2158.8717410810714 2193.3102145128855 2425.48836034236 2199.1834251878527 2256.6515081328516 3011.8397215964537 1890.2069439628806 2101.9649431956013 1.172932359904961 1.2021389382847087 1.0270731431890368 1.0434570860056365 1.153914753999136 1.0462512385408536 1.073591410474278 1.4328686743069923 0.899257121333914 1.0 11.03752289273496 -5.232644306331807 23.506986121117446 1.099261537567438 1.187535707708679 0.07953300562586052 0.13279916649473736 1018.323965165087 831304.6478649831 0.032749306020401735 0.0865979351323668 5.852692321469231e-06 5.232644306331807 0.08827417014124106 ALDSNS(ph)LENDDLSAPGREPGHFNPESR ddPTM_A459_Selumetinib_30min_R2 3 ALDSNSLENDDLSAPGREPGHFNPESR 27 1 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 ALDS(0.098)NS(0.902)LENDDLSAPGREPGHFNPESR;ALDS(0.265)NS(0.716)LENDDLS(0.018)APGREPGHFNPESR;ALDS(0.131)NS(0.869)LENDDLSAPGREPGHFNPESR 107.34 8.0311e-10 51906900.0 54924.8 57375.9 63971.0 65281.4 69724.1 49819.3 37788.0 51344.1 44420.9 51285.0 True False 51872.299497395106 61776.447037403705 59855.17550635851 56389.96070330368 60964.73521663734 56681.45636042218 39545.21687550147 51493.50283052667 53306.32122364792 49804.26879556753 1.041523161605208 1.2403845801045406 1.2018081372110314 1.1322314746707467 1.2240865430005685 1.138084299421874 0.7940125983542381 1.0339174547847088 1.0703163104844553 1.0 15.603981782611045 -7.027427065323476 24.40644811812078 0.9757680544307138 1.172834849760297 0.5409500906535074 0.08536012272376466 407.9094516263853 362984.06059699197 0.03195811135470199 0.024829331822823535 9.387996838562047e-08 7.027427065323476 0.19706679532958316 ALDSNSLENDDLS(ph)APGR ddPTM_A459_Selumetinib_30min_R2 1 ALDSNSLENDDLSAPGR 17 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 ALDSNS(0.013)LENDDLS(0.987)APGR 203.92 2.2543e-08 7982500.0 23889.0 15637.0 20039.0 19897.0 18505.0 15974.0 19821.0 23241.0 22338.0 17084.0 True False 22561.345015243973 16836.307619120256 18749.712556813534 17186.994275760528 16180.236463201029 18174.273502465603 20742.7157745664 23308.627462245327 26806.22417586874 16590.740530437284 1.3598757074075778 1.014801454355365 1.130131142875474 1.0359389470427411 0.9752570377143114 1.095446792692778 1.250258584691378 1.40491784676419 1.6157340371088431 1.0 14.018090662211275 -7.468654999891377 3.016436418615599 1.3796648173959778 1.0908011717596549 0.27306669759337165 0.17244223179587106 0.28680599137808954 5.169547271539228 0.08224979911049186 0.04857207466898622 3.398951754165026e-08 7.468654999891377 -0.28886364563632294 ALDSNSLENDDLS(ph)APGREPGHFNPESR ddPTM_A459_Selumetinib_30min_R2 1 ALDSNSLENDDLSAPGREPGHFNPESR 27 1 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 ALDS(0.004)NS(0.024)LENDDLS(0.973)APGREPGHFNPESR 76.796 7.2714e-05 8722900.0 3095.2 3329.6 4092.1 4717.1 3897.8 2499.3 2881.7 2883.0 3114.5 3438.2 True False 2923.1811750673173 3584.9696136485795 3828.8187411416034 4074.6228425486274 3408.1235172258807 2843.555888613515 3015.70475998022 2891.3890526936557 3737.487026400894 3338.9302324835803 0.8754843532304003 1.0736880869121932 1.1467201991500229 1.2203378204514985 1.0207231897417732 0.8516368089842975 0.9031949007622908 0.8659627040313951 1.1193666133062197 1.0 11.705170233019231 -6.526798227892789 24.29760661286746 0.9367777825240622 1.0881350429502288 0.24200434411777028 0.1081971006367767 105.24453843999427 652417.7572386148 0.03651985702144931 0.036685422227826225 2.973046980955365e-07 6.526798227892789 0.1513572604261666 ALDTTDMERLKDVQS(ph)MDELK ddPTM_A459_Selumetinib_30min_R2 1 ALDTTDMERLKDVQSMDELK 20 2 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 ALDT(0.001)T(0.001)DMERLKDVQS(0.999)MDELK 40.179 0.039947 4840300.0 47926.0 39455.0 36476.0 31208.0 26133.0 22861.0 33990.0 31252.0 18441.0 30466.0 True False 45262.46478297888 42481.07163217941 34129.173872065956 26957.41656319721 22849.938908015793 26009.895238504196 35570.60234990726 31342.93814595287 22129.715284591093 29586.36741982568 1.5298419079541588 1.4358326262017909 1.1535439071575972 0.9111431687667468 0.7723130921677177 0.879117563485509 1.2022632533817441 1.0593709495052819 0.7479700015407122 1.0 14.852644954516098 -5.375861603647257 2.27562100340412 0.9434770444523727 1.5150299916101124 0.7455649007445632 0.12648257473323418 0.16938612429343416 1.6646913740775124 0.03873796285494398 0.11387270941809412 4.208607224424355e-06 5.375861603647257 0.5715529471577397 ALDVMVS(ph)TFHK ddPTM_A459_Selumetinib_30min_R1 1 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 1 ALDVMVS(0.82)T(0.18)FHK 78.529 0.03136 6764500.0 6310.3 5159.4 8894.7 8818.3 6774.2 5592.7 5305.7 4744.8 3846.8 4133.8 True False 6457.31771229364 4555.335049460011 7686.848595089791 7278.349444992229 6161.474806082147 5536.442515765309 4905.486777356421 4618.952490717494 6527.738640844247 4664.413496621833 1.3843793473649593 0.9766147561229679 1.6479775218592723 1.5603997051855545 1.3209538156393188 1.1869536265974354 1.051683514102938 0.9902536501240159 1.3994768357419243 1.0 12.18747997266086 -6.789843394055435 3.1028406370587565 1.1116291905993683 1.385755594895214 0.30246762561058227 0.19553772924614887 0.3417057242080404 6.769471547069311 0.07495430846474889 0.06857016643286709 1.6223950251248066e-07 6.789843394055435 0.2741264042958458 ALDVS(ph)ASDDEIAR ddPTM_A459_Selumetinib_30min_R1 2 ALDVSASDDEIAR 13 0 C9JLK2;H7C393;H7C1U0;C9JIF9;P13798 C9JLK2 APEH Acylamino-acid-releasing enzyme 1 ALDVS(0.636)AS(0.364)DDEIAR;ALDVS(0.662)AS(0.338)DDEIAR 220.37 1.2126999999999998e-08 32733000.0 3973.9 3395.8999999999996 4598.799999999999 4431.200000000001 4648.799999999999 3543.9 3301.2 3785.1000000000004 2263.6 2833.1000000000004 True False 4066.4841381366487 2998.306449288921 3974.308219400194 3657.3741039258766 4228.316860812301 3508.251583603749 3052.187826188632 3684.706852262433 3841.163873197215 3196.7559817309293 1.2720658571927634 0.9379215887680752 1.2432316517472342 1.1440892344699827 1.3226899034448096 1.097441157114581 0.9547766059190983 1.1526393860901751 1.201581820804903 1.0 11.64239290760985 -6.9731522103801655 24.997191913044958 1.0808463518177813 1.175268420305332 0.1626916558459659 0.11627059174774919 464.6927608167668 432660.6356853524 0.0410612203767653 0.036211910839343865 1.0637701255457842e-07 6.9731522103801655 0.09442206848755075 ALDVS(ph)ASDDEIAR ddPTM_A459_Selumetinib_30min_R2 1 ALDVSASDDEIAR 13 0 C9JLK2;H7C393;H7C1U0;C9JIF9;P13798 C9JLK2 APEH Acylamino-acid-releasing enzyme 1 ALDVS(0.651)AS(0.349)DDEIAR 169.58 0.00025018 10869000.0 21940.0 16148.0 16830.0 24959.0 21915.0 18893.0 15744.0 18254.0 19540.0 21221.0 True False 20720.66263277879 17386.49967599628 15747.176123118497 21559.54114332347 19161.841777414236 21495.33925642183 16476.127196144156 18307.116117887632 23448.545993216736 20608.294591220416 1.0054525638238034 0.8436651368232726 0.7641183530939595 1.0461584313972445 0.9298121051500108 1.0430430893383733 0.7994900850827 0.8883372681253724 1.1378207881018125 1.0 14.330937501283051 -8.251188291183572 24.77442133146354 1.0689103967803122 0.912883939233364 0.2883515189848037 0.09666408253357243 694.1014057541915 1677487.740459821 0.06743458155433245 0.024845986376251874 5.608047827739297e-09 8.251188291183572 -0.15602645754694822 ALDVSAS(ph)DDEIAR ddPTM_A459_Selumetinib_30min_R2 3 ALDVSASDDEIAR 13 0 C9JLK2;H7C393;H7C1U0;C9JIF9;P13798 C9JLK2 APEH Acylamino-acid-releasing enzyme 1 ALDVS(0.01)AS(0.99)DDEIAR;ALDVS(0.008)AS(0.992)DDEIAR;ALDVS(0.014)AS(0.986)DDEIAR 190.57 0.00016479 26350400.0 85895.0 67418.0 65539.0 83615.0 83319.0 72060.0 75583.0 82401.0 64518.0 74069.0 True False 81121.29976492861 72588.7438169631 61322.292093467804 72226.49275607955 72851.7223386894 81985.61090444916 79097.75926487314 82640.77326778005 77423.40278353913 71930.4355156264 1.127774344523544 1.0091520132836356 0.852522185551705 1.004115882773834 1.0128080250933953 1.1397902753784708 1.0996424350536522 1.1488985528222875 1.0763649938796689 1.0 16.134314718734643 -6.642782808839731 5.364184607798088 1.1023007793305208 0.9911082997624049 0.27736254487577516 0.072939953278434 0.2524741293471971 10.861779792579217 0.0250603531861312 0.024963095048598193 2.2762354941130936e-07 6.642782808839731 -0.11119247956811595 ALEAELDAQHLSETFDNIDNLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ALEAELDAQHLSETFDNIDNLSPK 24 0 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7 P25054-2 APC Adenomatous polyposis coli protein 1 ALEAELDAQHLSETFDNIDNLS(1)PK 154.34 1.1984999999999998e-10 4611500.0 751.38 1048.0 906.65 1008.1 1215.9 1121.1 1506.1 787.79 247.36 591.69 True False 768.8856920690296 925.2996727980178 783.5319098719641 832.0542593806815 1105.92205968458 1109.8227518773563 1392.493664431933 766.8952500974399 419.751853540406 667.6391750486653 1.151648556292378 1.3859277696378007 1.1735858816476 1.2462633866864266 1.6564666979045495 1.6623092133508486 2.0856979585274216 1.1486672423641702 0.6287106407586248 1.0 9.382924799942973 -7.998809185150267 24.999624976622023 0.8391330643412602 1.4801648949534316 0.4839551612542704 0.27687346647699557 33.54823830211771 704308.7400396672 0.16613862992948886 0.07879950725833132 1.0027457151114876e-08 7.998809185150267 0.6410318306121714 ALEATTEHIR ddPTM_A459_Selumetinib_30min_R1 1 ALEATTEHIR 10 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 166.66 0.00044901 3694800.0 2458.0 3006.9 2938.3 3061.9 3188.6 2782.2 3087.4 3010.4 1890.4 2229.2 False True 2515.26661756458 2654.850750130114 2539.2949989265894 2527.1966439814596 2900.1916929930544 2754.213594035482 2854.5149323200008 2930.5544128426777 3207.8707306467622 2515.3395342467893 0.9999710111970107 1.0554641685481643 1.009523749916718 1.004713920157988 1.1530020712935314 1.094966924558844 1.1348427889973813 1.1650730936888103 1.2753231470229125 1.0 11.296537440681611 -6.262870486734324 24.95439265555039 1.14322534763633 1.019571887079714 0.4434018893159736 0.06552065023521302 115.43789871637911 2012910.8135295871 0.019590922284322403 0.023465583914941895 5.459206387138535e-07 6.262870486734324 -0.12365346055661619 ALEEGDGSVSGSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ALEEGDGSVSGSSPR 15 0 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 ALEEGDGSVSGS(0.006)S(0.994)PR;ALEEGDGSVSGS(0.003)S(0.997)PR 292.16 2.3948999999999996e-67 200908000.0 4270.2 4913.1 5219.700000000001 4939.700000000001 5150.0 4203.4 4644.1 4367.9 2641.2 3873.0 True False 4369.687351637212 4337.871967961777 4510.893409759766 4077.074124653062 4684.183409306351 4161.117612381836 4293.791798013642 4252.049103061233 4481.923494384378 4370.137276214706 0.999897045664917 0.9926168661958198 1.032208629763452 0.9329396005117059 1.0718618462630225 0.952170915780953 0.982530187640423 0.9729783835862114 1.02557956675139 1.0 12.093462883519216 ALEEGDGSVSGSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ALEEGDGSVSGSSPR 15 0 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 ALEEGDGSVSGS(0.002)S(0.998)PR;ALEEGDGSVSGS(0.002)S(0.998)PR 247.17 7.2958999999999985e-28 381980000.0 966550.0 914660.0 1027200.0 990840.0 1139250.0 890240.0 810650.0 867230.0 688780.0 980340.0 True False 912833.020406214 984811.4809045558 961111.0703307987 855885.8827056634 996127.2299757778 1012862.4792058961 848346.8312725007 869753.495722344 826555.2461211786 952035.0369707826 0.9588229266337689 1.0344277706816993 1.0095332976283042 0.8990067061281172 1.0463136242814017 1.063892020643123 0.891087825897458 0.9135729904329521 0.8681983477741956 1.0 19.8606551432787 -7.279460399141451 24.8973499767862 0.911012533945342 1.001148658578609 0.3603163439878405 0.05434540373528283 853.0887017898425 1178599.2852424164 0.022764994784010218 0.015386097166936978 5.2545992664571274e-08 7.279460399141451 0.09013612463326692 ALEESESSQLIS(ph)PPLAQAIR ddPTM_A459_Selumetinib_30min_R2 2 ALEESESSQLISPPLAQAIR 20 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 ALEESESSQLIS(1)PPLAQAIR;ALEESES(0.022)S(0.281)QLIS(0.697)PPLAQAIR 188.56 4.9486e-17 1542000.0 8737.7 6775.8 8449.0 10593.3 9996.3 8238.6 8736.9 8660.9 6365.0 6990.7 True False 8252.093613784471 7295.482072369067 7905.400538575653 9150.474265538225 8740.475425944138 9373.392367435401 9143.183161838911 8686.101785110819 7638.177852959289 6788.86032698009 1.2155344514880122 1.0746254483061872 1.164466516884762 1.3478660371274216 1.2874731552817484 1.380701902230031 1.3467920566140301 1.2794639109882358 1.1251045808976017 1.0 12.728953688496514 -5.622293518752708 6.900327110603203 1.2745266102313388 1.139003723390225 0.12248060908126346 0.11393633458220737 0.32226531187306623 19.21105725016945 0.03004265974771422 0.05235151480876423 2.386198021334397e-06 5.622293518752708 -0.1355228868411138 ALEIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ALEISPR 7 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 ALEIS(1)PR;ALEIS(1)PR 88.177 0.03262 18539000.0 74337.0 65423.0 91583.0 86170.0 93337.0 63721.0 66977.0 70991.0 60840.0 77906.0 True False 70205.64713458881 70440.733731899 85690.64948803105 74433.49734845867 81611.17161663307 72497.9893483542 70091.56321240764 71197.57205680723 73009.70001163293 75656.65135590294 0.9279507601298451 0.9310580427427684 1.1326254592597063 0.9838328291627615 1.0787045177656485 0.9582500421187053 0.9264428435073594 0.9410616354387749 0.9650136333444331 1.0 16.207179302128317 -6.963412685966419 24.997232728121134 0.9516648541830119 1.0123493285130836 0.15561809159150064 0.06056153505944042 299.58558442326745 204682.43136856487 0.021860042083386457 0.019278695874040876 1.0878958349191986e-07 6.963412685966419 0.060684474330071625 ALELDHK ddPTM_A459_Selumetinib_30min_R2 1 ALELDHK 7 0 K7EJE9;A0A6I8PUC2;A0A6I8PUD4;A0A6I8PS32;A0A6I8PR89;A0A6I8PRZ0;K7ER44;A0A6I8PLE7;K7EJL5;A0A6I8PU89;K7EIH8;K7EPP7;K7EK03;K7ESP1;K7ELJ8;K7EJV7;K7EN19;A0A6I8PU73;Q99615-2;Q99615 K7EJE9 DNAJC7 DnaJ homolog subfamily C member 7 0 116.9 0.016836 1079500.0 19561.0 18127.0 18125.0 20839.0 20784.0 17282.0 19047.0 19640.0 18094.0 21625.0 False True 18473.877928887236 19517.282612508337 16958.85723300789 18000.692250719887 18172.92810868251 19662.43862962378 19932.723240914485 19697.149148422977 21713.305588600986 21000.630061502365 0.8796820797654502 0.9293665264018317 0.8075404015661551 0.8571501044493964 0.865351565903563 0.9362785103132828 0.9491488199420488 0.9379313425710554 1.033935911685101 1.0 14.358144991867945 -7.418227370056701 0.9565089372536156 1.0065078142357378 0.8665281965682852 0.7092382111725003 0.03499274778669365 0.3333960214594015 0.5734376794540179 0.02914326212440322 0.014827082832929588 3.817443604904144e-08 7.418227370056701 -0.1399796176674526 ALENDFFNS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 3 ALENDFFNSPPR 12 0 F5H148;H3BMT1;Q9NYV6-2;A6NIE6;Q9NYV6-3;Q9NYV6 F5H148 RRN3;RRN3P2 RNA polymerase I-specific transcription initiation factor RRN3;Putative RRN3-like protein RRN3P2 1 ALENDFFNS(1)PPR;ALENDFFNS(1)PPR;ALENDFFNS(1)PPR 188.13 0.00012135 37540700.0 6650.7 7462.4 7892.1 8253.4 8350.3 6746.4 6996.4 7119.0 4528.76 6293.0 True False 6805.648369990541 6588.698738824357 6820.396168202205 6812.098625505915 7595.0168393652 6678.537341241096 6468.655915166044 6930.180994229015 7684.974952456539 7100.76784901088 0.9584383709908995 0.9278853891473366 0.9605153010532896 0.9593467594430403 1.0696050062280473 0.9405373451508348 0.91097977749929 0.9759762805362482 1.0822737929007265 1.0 12.79375932506292 -2.2679883153686244 0.15550977774237468 1.0195218912179353 0.7722290513416706 0.14249662788795192 0.050032620257635795 121.07773358462154 1.5113209113562076 0.1802945925645815 6.521650450279571 0.005395251381670979 2.2679883153686244 -0.24729283987626471 ALENDFFNS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 ALENDFFNSPPR 12 0 F5H148;H3BMT1;Q9NYV6-2;A6NIE6;Q9NYV6-3;Q9NYV6 F5H148 RRN3;RRN3P2 RNA polymerase I-specific transcription initiation factor RRN3;Putative RRN3-like protein RRN3P2 1 ALENDFFNS(1)PPR 141.82 0.00096041 3617900.0 12385.0 14550.0 14253.0 14920.0 21281.0 12640.0 13352.0 13651.0 12620.0 15965.0 True False 11696.691281083196 15665.93821437614 13335.97749749305 12887.870261564414 18607.49052544614 14381.04526550427 13972.894456486074 13690.722149955285 15144.352632261774 15504.048967948434 0.7544281693939306 1.0104417398811356 0.8601609505402463 0.8312583563305009 1.2001697468779582 0.9275670694303305 0.9012416359992335 0.8830417253104756 0.9767998452255755 1.0 13.920357412026588 -4.7501210811620265 24.956668450372774 0.949233832486324 0.7544277351645686 0.2653628988722476 0.0995282018306262 733.0758085547005 1616315.606105686 0.02510703798991829 0.3813873827704277 1.7777836954164712e-05 4.7501210811620265 -0.19480609732175536 ALES(ph)PERPFLAILGGAK ddPTM_A459_Selumetinib_30min_R1 1 ALESPERPFLAILGGAK 17 1 P00558-2;P00558 P00558-2 PGK1 Phosphoglycerate kinase 1 1 ALES(1)PERPFLAILGGAK 136.63 0.0021868 0.0 882.16 980.29 1118.8 1069.8 793.24 931.72 807.99 872.43 478.19 547.89 True False 902.7126116154477 865.5171910755435 966.873105128499 882.9795126331245 721.4915820578968 922.3477427340741 747.0426637835186 849.2903223479726 811.4535043842448 618.2170184005358 1.460187255845795 1.4000216191311392 1.5639703798999478 1.428267883853453 1.1670522819390432 1.491948159435002 1.2083825607329335 1.373773767252921 1.312570634958666 1.0 9.271969559312357 -13.662678665397065 0.11829400034293977 3.524772633490138e-10 1.5817201882799188 0.5902417007401086 0.10397095168567057 87.6349061412742 0.8235845620110063 22.094422338452844 1.0984387827094253 2.1743093559171354e-14 13.662678665397065 1.5817201879274416 ALESPERPFLAILGGAK ddPTM_A459_Selumetinib_30min_R1 1 ALESPERPFLAILGGAK 17 1 P00558-2;P00558 P00558-2 PGK1 Phosphoglycerate kinase 1 0 160.63 7.0692e-05 3826000.0 968.07 1214.7 1134.9 1135.5 1028.4 852.42 837.05 890.56 833.72 945.3 False True 990.624147463687 1072.4823593012904 980.7868135594682 937.2062409748677 935.3814015787673 843.8454287354348 773.9106445871784 866.9394558534339 1414.761947500433 1066.638463001746 0.9287346948617072 1.00547879764536 0.9195119504685092 0.8786540833502022 0.8769432511803544 0.7911260075514954 0.7255604137968458 0.8127772304532157 1.3263743963620007 1.0 10.058855542342203 -8.248035280073465 24.992272185593592 1.163187210048207 0.8671211188717416 0.5647066220575692 0.10389488336899182 505.91276701839547 943291.2738626815 0.07421554744590213 0.027706284316771124 5.648910838114383e-09 8.248035280073465 -0.29606609117646543 ALEYSNGIFDCQS(ph)PTSPFMGSLR ddPTM_A459_Selumetinib_30min_R1 1 ALEYSNGIFDCQSPTSPFMGSLR 23 0 Q86W92-2;Q86W92-4;Q86W92;F5H6Q7;F5H0E0;F5H495;A0A0A0MTP2;Q86W92-5 Q86W92-2 PPFIBP1 Liprin-beta-1 1 ALEYSNGIFDCQS(0.865)PT(0.1)S(0.035)PFMGSLR 112.01 9.1924e-06 10488000.0 1553.0 1806.6 1966.8 2394.8 1846.3 1495.5 1881.0 1738.5 904.99 1520.9 True False 1589.1818783880362 1595.0824321344455 1699.719362859073 1976.5931359635513 1679.3024909907397 1480.4566278053567 1739.1146555982125 1692.3893325561378 1535.701932145586 1716.1223298205377 0.9260306510633328 0.9294689570884205 0.9904418428241185 1.1517786941040806 0.9785447469623867 0.8626754643768165 1.0133978361438134 0.9861705678831871 0.894867402783682 1.0 10.744936680352193 -6.52535616273625 24.994451115944198 0.9506734723997615 1.002712168055665 0.08925238578319883 0.07218135203254132 205.31840286356683 2071409.5885867432 0.025241983587250445 0.025380681535256164 2.9829353251815457e-07 6.52535616273625 0.052038695655903466 ALEYSNGIFDCQS(ph)PTSPFMGSLR ddPTM_A459_Selumetinib_30min_R2 1 ALEYSNGIFDCQSPTSPFMGSLR 23 0 Q86W92-2;Q86W92-4;Q86W92;F5H6Q7;F5H0E0;F5H495;A0A0A0MTP2;Q86W92-5 Q86W92-2 PPFIBP1 Liprin-beta-1 1 ALEY(0.002)S(0.009)NGIFDCQS(0.869)PT(0.06)S(0.06)PFMGSLR 70.57 0.0015713 3155000.0 5817.3 5908.0 6055.8 5660.3 6964.9 5374.8 3658.5 4880.2 5265.8 6955.1 True False 5493.997754496993 6361.12460278586 5666.176421056503 4889.357375437873 6089.906995003985 6115.129912423446 3828.6274991802225 4894.4005740394 6319.107138745172 6754.288191479997 0.8134088446843649 0.9417905221766991 0.8389006006886024 0.7238893628503167 0.9016356457347975 0.90537000185115 0.5668439649954136 0.7246360290360873 0.9355696647229576 1.0 12.721588022128415 ALGVS(ph)NFSHFQIEK ddPTM_A459_Selumetinib_30min_R1 2 ALGVSNFSHFQIEK 14 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 ALGVS(0.935)NFS(0.065)HFQIEK;ALGVS(0.998)NFS(0.002)HFQIEK 160.48 0.00029039 29090300.0 3724.2999999999997 6210.0 5809.599999999999 6868.400000000001 7121.9 5385.6 6834.7 6319.6 2134.4900000000002 4786.8 True False 3811.068943773702 5482.9303130493245 5020.6882298485225 5668.962875835998 6477.725402473567 5331.425753733552 6319.15307635146 6151.983679046171 3622.0736330185214 5401.232407380469 0.7055924752591831 1.0151257897285109 0.9295449355202795 1.0495684037016608 1.1993050685288291 0.98707579152648 1.169946523263229 1.138996291039031 0.670601329442734 1.0 12.399072911411826 -4.2972466475166 1.5055400764895888 1.0382006381341702 1.5437938327865585e-13 0.2890002010729439 0.14337468102320594 5.318218384054541 4.149047777252963 0.03957785591339217 11.800787922003773 5.0437476821136745e-05 4.2972466475166 -1.0382006381340159 ALGVSNFS(ph)HFQIEK ddPTM_A459_Selumetinib_30min_R1 1 ALGVSNFSHFQIEK 14 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 ALGVS(0.053)NFS(0.947)HFQIEK 77.795 0.026079 16405000.0 3165.7 6649.0 6239.6 7410.2 7902.4 5908.1 8202.8 6692.2 1458.9 3994.5 True False 3239.454650620093 5870.531988963758 5392.296591669451 6116.1476766816 7187.629315282033 5848.6698781255955 7584.056191887831 6514.701116670796 2475.64674615984 4507.232984724925 0.7187235853124633 1.3024691665283494 1.1963651779138151 1.3569628411509478 1.5946877695564015 1.2976187159498564 1.6826412607447414 1.4453881436236398 0.5492608779155285 1.0 12.138026311422639 -8.25385290814359 24.757306300282693 0.7746304246042266 1.3405105090630651 0.4057139795794251 0.2655553103636545 440.3163297385275 1436919.48653311 0.18979474026684498 0.06861847708960822 5.5737449497939424e-09 8.25385290814359 0.5658800844588385 ALGVSNFSHFQIEK ddPTM_A459_Selumetinib_30min_R1 2 ALGVSNFSHFQIEK 14 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 0 ; 180.3 0.00010339 30617000.0 12603.5 14414.800000000001 14613.400000000001 15889.9 15765.6 13681.6 15303.4 12873.5 5750.3 9100.2 False True 12897.137027858093 12727.108514741296 12628.980545660355 13115.027255364635 14339.604263642757 13543.975525898875 14149.052217161974 12532.052960978677 9757.839114704873 10268.299313454443 1.256014909008263 1.239456323411327 1.2298999240422157 1.277234608673722 1.3964926251082033 1.319008641299767 1.3779353118994713 1.2204604266412513 0.9502877562128794 1.0 13.325909634699176 -8.163376045027691 3.9017056949642397 0.9741207959438556 1.2980770287328467 0.8475360876817397 0.05405443406263537 0.09048938513268977 2.377890464838988 0.04673275075913866 0.015620711251419627 6.864737816521834e-09 8.163376045027691 0.3239562327889911 ALHELNPR ddPTM_A459_Selumetinib_30min_R2 1 ALHELNPR 8 0 Q5T6V5 Q5T6V5 C9orf64 UPF0553 protein C9orf64 0 93.374 0.041284 0.0 3216.1 5785.2 5045.4 5895.5 6237.7 4138.8 4500.3 4591.7 3399.2 5256.8 False True 3037.362037068364 6228.906237650097 4720.784457016164 5092.522729695243 5454.064360254469 4708.8821317143265 4709.572867175278 4605.0610868031445 4079.134981583535 5105.022525193319 0.5949752468434689 1.2201525472043278 0.9247333256061188 0.9975514710392775 1.0683722419124746 0.9224018324064122 0.9225371374824509 0.9020647928735159 0.799043483442625 1.0 12.317701611468005 -6.982879705841446 24.335157261891236 0.9012813944781828 0.9775283074256892 0.022805136696482653 0.15404694004186562 587.5862461646124 835203.5019322487 0.05131834104945232 0.04524762252062321 1.04020825064981e-07 6.982879705841446 0.0762469129475064 ALHS(ph)FITPPTTPQLR ddPTM_A459_Selumetinib_30min_R1 1 ALHSFITPPTTPQLR 15 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;J3QR75 A0A2R8Y4X0 KSR1 Kinase suppressor of Ras 1 1 ALHS(0.99)FIT(0.01)PPTTPQLR 154.13 0.00019416 12076000.0 1824.5 1955.1 2315.5 2322.5 2252.8 1656.4 1804.2 1708.6 1012.5 1514.3 True False 1867.007300141 1726.1959830986677 2001.0678181310675 1916.918973724464 2049.034637764144 1639.7381198908677 1668.107741430246 1663.282377685026 1718.138549925861 1708.675155531095 1.092663689816858 1.0102540424438529 1.171122440478799 1.1218744344232254 1.1991949617405524 0.9596546860197074 0.9762579715813567 0.9734339334781514 1.0055384397462166 1.0 10.738662430037564 -6.778640851385391 24.99721539699194 0.980896654872393 1.1160322084388685 0.6655264782183695 0.04818799535258745 158.22647886498666 229933.64957343478 0.017827180206605387 0.015759486559594568 1.6647888120830937e-07 6.778640851385391 0.13513555356647555 ALHS(ph)FITPPTTPQLR ddPTM_A459_Selumetinib_30min_R2 1 ALHSFITPPTTPQLR 15 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;J3QR75 A0A2R8Y4X0 KSR1 Kinase suppressor of Ras 1 1 ALHS(0.585)FIT(0.297)PPT(0.043)T(0.075)PQLR 136.6 0.00040502 8505900.0 17022.0 13494.0 17129.0 18413.0 18549.0 13350.0 10681.0 13810.0 11400.0 12920.0 True False 16075.985384464931 14528.946409951312 16026.93878864509 15905.117635803319 16218.70878983602 15188.84132076597 11177.687663999985 13850.18481363143 13680.31854261365 12546.966029808578 1.2812647572546423 1.157964911631547 1.277355716957305 1.267646504981091 1.2926398900980733 1.210558894053027 0.8908677713356745 1.1038672441390784 1.0903288101770976 1.0 13.61505092915042 -7.095016264552399 6.890177268831993 1.0306937175354802 1.251871795878339 0.7489471477087339 0.0645910742995147 0.13373355779125928 8.331175994722571 0.024704877140434102 0.019142232050819122 8.034960302812862e-08 7.095016264552399 0.22117807834285874 ALHSFIT(ph)PPT(ph)TPQLR ddPTM_A459_Selumetinib_30min_R2 1 ALHSFITPPTTPQLR 15 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;J3QR75 A0A2R8Y4X0 KSR1 Kinase suppressor of Ras 1 2 ALHS(0.003)FIT(0.997)PPT(0.554)T(0.446)PQLR 78.917 0.032984 0.0 6025.9 5059.2 6125.4 6254.3 6177.5 5496.9 5883.1 5413.5 2989.8 5161.2 True False 5691.004601588953 5447.224372108026 5731.298432831254 5402.45355073072 5401.427222449298 6254.048079109995 6156.675807141491 5429.252388746833 3587.843541991782 5012.182745591953 1.1354343786834191 1.086796840537923 1.1434735570788475 1.077864440493914 1.07765967376183 1.2477693644770278 1.228342245213641 1.0832111805024824 0.7158245666814863 1.0 12.291223301347577 -8.102578062389306 6.15521267679401 0.862256039353833 1.1405413963697784 0.6400504144895962 0.08406754304955309 0.1427256227182311 7.131545057899188 0.05738034925062723 0.02125705314648766 7.896269049232149e-09 8.102578062389306 0.27828535701594537 ALHSFIT(ph)PPTTPQLR ddPTM_A459_Selumetinib_30min_R1 1 ALHSFITPPTTPQLR 15 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;J3QR75 A0A2R8Y4X0 KSR1 Kinase suppressor of Ras 1 1 ALHS(0.087)FIT(0.866)PPT(0.019)T(0.029)PQLR 105.19 0.011207 20087000.0 2126.6 2223.2 2786.9 2776.2 2156.5 1861.4 1832.5 2001.2 1278.0 1903.4 True False 2176.1456423567256 1962.9067104623598 2408.4542873459186 2291.3887857282475 1961.4449557609992 1842.6760060159752 1694.2730496457864 1948.1216751862767 2168.672658573088 2147.719930686049 1.013235297239895 0.9139491059410834 1.121400538745563 1.06689366382902 0.9132684982508181 0.8579684807540836 0.7888705717344545 0.9070650448189423 1.0097558008321625 1.0 11.06859015836056 -6.334135367116161 6.303364122282614 0.8983236552808623 1.0270342380077366 0.3414858824921564 0.07748872787762508 0.2651321477371973 18.56971638423517 0.025462963703458547 0.028983083727881154 4.633024884816826e-07 6.334135367116161 0.1287105827268743 ALHSFIT(ph)PPTTPQLR ddPTM_A459_Selumetinib_30min_R2 1 ALHSFITPPTTPQLR 15 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;J3QR75 A0A2R8Y4X0 KSR1 Kinase suppressor of Ras 1 1 ALHSFIT(1)PPTTPQLR 88.385 0.023971 34317000.0 24929.0 34661.0 32714.0 36135.0 46113.0 27350.0 27646.0 22390.0 24687.0 29368.0 True False 23543.545978693823 37319.38724731902 30609.216856310068 31213.350663648132 40319.87268454949 31117.214241419424 28931.593779509738 22455.151193135964 29625.08981241257 28520.069532772297 0.8255080146855893 1.308530724458279 1.0732518313511523 1.0944345920258363 1.413736829716284 1.0910637579499152 1.0144292862352442 0.7873455977143689 1.038745357137734 1.0 14.79968987866868 -7.317703389528772 3.285859330796319 0.9325540505836789 1.1523584389653132 0.2281030728516933 0.15825543573076395 0.3311103881981566 7.162161891884036 0.06935222739438292 0.045728978990652105 4.811678598770956e-08 7.317703389528772 0.2198043883816343 ALIEVLQPLIAEHQAR ddPTM_A459_Selumetinib_30min_R1 1 ALIEVLQPLIAEHQAR 16 0 P23381-2;P23381 P23381-2 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 78.69 0.036298 1941000.0 876.71 907.36 927.77 1164.0 899.44 838.44 856.38 866.54 458.97 744.59 False True 897.1356372193012 801.1258693797803 801.7839298758195 960.729250986125 818.0858108090298 830.0060548426098 791.7825671245067 843.5565442813893 778.8385681575035 840.165379420787 1.0678083853416929 0.9535335411369597 0.9543167922826958 1.143500166179729 0.9737199732902837 0.9879079466649995 0.9424127517255763 1.0040363063554705 0.9270062623794825 1.0 9.714529527887887 -6.466377690152689 24.99983225506168 0.9717862877339267 1.0239091775841602 0.19975705812007472 0.055667778635498266 534.2029203343543 236366.75399024633 0.01737952580316818 0.019706459722247747 3.4168216468576453e-07 6.466377690152689 0.0521228898502335 ALINADELASDVAGAEALLDR ddPTM_A459_Selumetinib_30min_R1 1 ALINADELASDVAGAEALLDR 21 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 165.02 8.7634e-08 0.0 123.76 0.0 77.877 0.0 0.0 80.936 0.0 75.97800000000002 135.63 0.0 False True 126.64336720496028 0.0 67.30173114774048 0.0 0.0 80.12185732400827 0.0 73.96281662867432 230.15420397673532 0.0 0.0 ALIQTCLNSPDS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 ALIQTCLNSPDSPPR 15 0 P11831 P11831 SRF Serum response factor 1 ALIQTCLNSPDS(1)PPR;ALIQTCLNS(0.001)PDS(0.999)PPR 229.92 7.4436e-14 12083400.0 2667.3 3145.2 2639.12 2527.1 2482.4 2585.5 2780.7 2544.8 1816.75 2614.1 True False 2729.442900337676 2776.958521836189 2280.7419996484837 2085.789424542128 2257.867358303318 2559.4922174461726 2570.9495602455863 2477.303637324626 3082.892059829932 2949.6451984902815 0.9253461744262287 0.9414551022128089 0.7732258784262721 0.7071323105605036 0.7654708300032028 0.8677288437118468 0.8716131559014205 0.8398649568404314 1.0451738607097052 1.0 11.526325713318668 -8.255649366211522 23.215565777256174 1.0225869562549792 0.8334045790319271 0.5354730002010332 0.06928885689404807 136.2971458952328 546511.1966694584 0.05648123432352154 0.019961235034446377 5.550736786779915e-09 8.255649366211522 -0.1891823772230521 ALIQTCLNSPDS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 4 ALIQTCLNSPDSPPR 15 0 P11831 P11831 SRF Serum response factor 1 ALIQTCLNSPDS(1)PPR;ALIQTCLNS(0.003)PDS(0.997)PPR;ALIQTCLNS(0.004)PDS(0.996)PPR;ALIQTCLNSPDS(1)PPR 303.07 8.2551e-81 38171100.0 77225.0 61689.5 72584.0 79928.0 82700.0 63628.0 77281.0 83255.0 76324.0 64170.8 True False 72933.14365616873 66420.88628699364 67914.02446348386 69041.66851650954 72310.48665261951 72392.17944252412 80874.7196293963 83497.25826639279 91590.93267074093 62318.02226823839 1.1703379054976932 1.0658375197000813 1.0897974934306858 1.1078924844458355 1.1603463014498452 1.161657202966472 1.2977741700672631 1.3398573193961711 1.4697342652579983 1.0 15.927361828143512 -7.122325480956816 2.14679845309495 1.3086855604376224 1.1123158144835985 0.28500192967962934 0.11424860207561291 0.3402812666519185 3.082374339612819 0.05002125122476592 0.035905407391197526 7.545265376122263e-08 7.122325480956816 -0.1963697459540239 ALIQTCLNSPDS(ph)PPRSDPTTDQR ddPTM_A459_Selumetinib_30min_R1 1 ALIQTCLNSPDSPPRSDPTTDQR 23 1 P11831 P11831 SRF Serum response factor 1 ALIQT(0.002)CLNS(0.063)PDS(0.923)PPRS(0.012)DPTTDQR 78.645 0.00037924 19173000.0 1352.1 1313.0 1578.6 1541.2 1459.4 1353.9 1640.6 1494.4 792.95 1127.7 True False 1383.601299271386 1159.2733496028598 1364.234790629109 1272.0583519070583 1327.397527677998 1340.280995242844 1516.848221145362 1454.7636575046836 1345.5782352234185 1272.4512797282011 1.087351100442075 0.9110551956460632 1.0721312574894915 0.9996912040347613 1.0431814159215065 1.0533063360422974 1.1920678184781774 1.1432765094278696 1.05746935592759 1.0 10.31339470336768 -7.028493364714485 7.5291671563251095 1.1120572976723002 1.0207593896172982 0.21671065753403096 0.06555493282500222 0.27753096259426957 60.226120579960586 0.023790743892316835 0.018945405859424266 9.364975278841094e-08 7.028493364714485 -0.09129790805500204 ALIQTCLNSPDSPPRS(ph)DPTTDQR ddPTM_A459_Selumetinib_30min_R1 2 ALIQTCLNSPDSPPRSDPTTDQR 23 1 P11831 P11831 SRF Serum response factor 1 ALIQTCLNSPDSPPRS(0.992)DPT(0.004)T(0.004)DQR;ALIQTCLNS(0.009)PDS(0.279)PPRS(0.503)DPT(0.105)T(0.105)DQR 125.51 5.5264e-06 36385000.0 2628.9 2919.1 3454.4 3415.8999999999996 3444.1 2853.8 2429.9 2381.1 1412.05 2155.8 True False 2690.148255051066 2577.330414947227 2985.311453660963 2819.3771893844532 3132.5817631052423 2825.0933630430823 2246.610686676287 2317.945493097164 2396.1457179484546 2432.5179292702474 1.1059109668548701 1.0595319294194978 1.2272515724299524 1.1590365503411781 1.2877939049949834 1.1613864502493543 0.9235741532027547 0.9528996539781087 0.9850475053506782 1.0 11.248234723326828 -7.253102858200654 23.556461720362183 0.9614552981682761 1.1698340277342167 0.723344213874616 0.060993798350371074 155.10654815670526 438284.71877862996 0.025326002581169075 0.019248607947266343 5.583379424521294e-08 7.253102858200654 0.2083787295659406 ALIQTCLNSPDSPPRS(ph)DPTTDQR ddPTM_A459_Selumetinib_30min_R2 2 ALIQTCLNSPDSPPRSDPTTDQR 23 1 P11831 P11831 SRF Serum response factor 1 ALIQTCLNSPDS(0.064)PPRS(0.916)DPT(0.01)T(0.01)DQR;ALIQT(0.021)CLNS(0.053)PDS(0.291)PPRS(0.499)DPT(0.067)T(0.067)DQR 137.89 2.3082e-06 56452000.0 17947.6 17927.6 17922.1 16726.1 21721.2 7607.7 10493.3 11792.7 11884.6 17408.0 True False 16950.14424193531 19302.5892736804 16769.011598107063 14447.976325868127 18992.388666008217 8655.591619175375 10981.259242079486 11827.014804613418 14261.852083468959 16905.38580858418 1.002647584258527 1.1418011687067784 0.9919330909083501 0.8546374799995258 1.1234519508193836 0.5120020162320258 0.6495716434051122 0.6996004077356178 0.8436277198848138 1.0 14.045195320819472 -6.74955350374535 24.999973441760496 0.716473567068819 1.018432546719981 0.498046128356024 0.14041150565869373 177.38188122726623 373092.8610050406 0.046051810764946494 0.04570407570382616 1.7801085914371561e-07 6.74955350374535 0.30195897965116203 ALIQTCLNSPDSPPRSDPT(ph)TDQR ddPTM_A459_Selumetinib_30min_R1 1 ALIQTCLNSPDSPPRSDPTTDQR 23 1 P11831 P11831 SRF Serum response factor 1 ALIQTCLNS(0.008)PDS(0.25)PPRS(0.161)DPT(0.291)T(0.291)DQR 62.847 0.0094747 26128000.0 1036.5 1175.8 1544.6 1642.9 1109.2 1251.4 964.2 898.99 731.57 844.78 True False 1060.6484333220858 1038.13678938541 1334.8518038804782 1355.9983560524954 1008.8730558451656 1238.8120521802898 891.4696177181271 875.1458648689342 1241.420858241247 953.2157418540302 1.1127055363763676 1.0890890108111373 1.4003669319226262 1.4225513664042542 1.0583890000419847 1.2996135059317917 0.9352233482676175 0.9180984182728161 1.3023503533697947 1.0 9.896658966845518 -7.256212858994212 24.973066014911772 1.0320928973790064 1.232661017629312 0.2759190651961012 0.15181789924453515 591.8115057596613 2827767.8244191483 0.06104752179315159 0.04584504013189816 5.543539431112933e-08 7.256212858994212 0.20056812025030557 ALIQTCLNSPDSPPRSDPT(ph)TDQR ddPTM_A459_Selumetinib_30min_R2 2 ALIQTCLNSPDSPPRSDPTTDQR 23 1 P11831 P11831 SRF Serum response factor 1 ALIQTCLNSPDS(0.02)PPRS(0.092)DPT(0.444)T(0.444)DQR;ALIQTCLNSPDS(0.006)PPRS(0.024)DPT(0.485)T(0.485)DQR 97.621 8.9404e-05 53997000.0 16407.1 15888.4 18474.7 20580.5 22911.0 13427.0 12848.1 14100.8 10951.0 18001.7 True False 15495.259064825197 17106.98919074185 17286.05791573247 17777.400396657256 20032.715353061267 15276.44737182957 13445.562108027163 14141.830993486898 13141.505996505442 17481.944146966332 0.8863578864318767 0.9785518731170669 0.9887949401057973 1.0169006517357049 1.145908898040815 0.873841447118484 0.7691113754279092 0.8089392618235169 0.751718795462798 1.0 14.093578013771335 -6.985564304926519 24.738644477043348 0.8172285876184082 1.002677075730641 0.4697130576850901 0.08666225188050336 168.41801884468077 288618.9515709356 0.030113108437714607 0.026546356317165527 1.033798017693919e-07 6.985564304926519 0.1854484881122327 ALIVLAHSER ddPTM_A459_Selumetinib_30min_R1 2 ALIVLAHSER 10 0 B4DLR8;P15559-3;P15559-2;P15559;H3BRK3 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 ; 118.03 0.0082025 34995000.0 7751.299999999999 11895.9 8864.8 11112.3 8873.0 8533.4 8712.4 7173.6 4587.8 7350.299999999999 False True 7931.8902085957425 10503.122497746122 7661.008850860842 9171.745408705427 8070.43871665539 8447.561743707281 8055.216653606517 6983.332824863222 7785.161520345541 8293.782602985008 0.9563658210357459 1.2663850742803355 0.923705047212544 1.1058579477842152 0.9730709258946293 1.018541496453853 0.9712355675572412 0.8419961263935056 0.9386744134749313 1.0 13.017814516412118 -6.707317554824218 0.8941460687355934 0.9221019123505382 1.0782311743623165 0.22485397951977537 0.09665130168819146 0.7476036300251861 1.30352339478047 0.055831068167422 0.05490062394113098 1.9619251984094232e-07 6.707317554824218 0.15612926201177835 ALIVLAHSER ddPTM_A459_Selumetinib_30min_R2 2 ALIVLAHSER 10 0 B4DLR8;P15559-3;P15559-2;P15559;H3BRK3 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 ; 140.17 0.0020337 21184000.0 90539.0 93094.0 98601.0 95553.0 103514.0 77456.0 64398.0 71712.0 64208.0 88840.0 False True 85507.2048363335 100234.01045561071 92257.11900865169 82538.516561881 90509.64589309855 88124.86092443818 67392.63460221616 71920.67004743933 77051.3941214155 86274.95836595946 0.9911010849014923 1.1617972625433213 1.0693383196699697 0.9566914678969847 1.0490836229578515 1.0214419409005315 0.7811378397466316 0.833621614076794 0.8930910611927552 1.0 16.39665425200348 -7.145485935306887 5.962974064197924 0.8638192864806907 1.046963138577901 0.5527692807917719 0.0723156055977829 0.16640020812537312 7.564394374699724 0.02800252998189667 0.021619995121417275 7.153425601782605e-08 7.145485935306887 0.1831438520972103 ALLETAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 ALLETASPR 9 0 Q96BT3;H3BMP6;H3BQS6;H3BN05;H3BTS2;H3BQJ0;I3L4F8;H3BUW2;H3BTR4;Q96BT3-3;Q96BT3-2 Q96BT3 CENPT Centromere protein T 1 ALLETAS(1)PR;ALLETAS(1)PR;ALLETAS(1)PR;ALLETAS(1)PR 141.91 0.0021656 58834000.0 511031.0 471141.0 563650.0 609691.0 666728.0 505232.0 476526.0 526096.0 443922.0 518972.0 True False 482629.94283917884 507275.9997429123 527385.3726557186 526650.0340243602 582967.6680160549 574823.1219605426 498685.4032183557 527626.8522601193 532718.8042170283 503987.9299088091 0.9576220266356483 1.0065241043266615 1.0464246093178124 1.0449655691549034 1.1567095825519795 1.140549381935695 0.9894788617429533 1.0469037469916935 1.0570070682316097 1.0 18.94302965723101 -5.037106479295161 1.5596561842740966 1.0676154227314176 0.9448113383011899 0.3053248441265357 0.04999440201817165 0.8572769903493707 2.818864467668256 0.015544468245252964 0.13963402628293026 9.18107469466088e-06 5.037106479295161 -0.12280408443022772 ALLFVPR ddPTM_A459_Selumetinib_30min_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 154.34 0.023879 7505400.0 2211.0 2939.9 2676.2 3076.4 3100.4 2489.1 2524.9 2396.4 1832.4 2035.1 False True 2262.5119981429157 2595.695141277569 2312.7867393143442 2539.1644911801695 2819.9693674200785 2464.0619139219757 2334.4447601913485 2332.8396873957595 3109.4489667991593 2296.324908552685 0.985275206359591 1.1303692833753083 1.0071687724591354 1.1057514037856864 1.2280358745912108 1.0730458502385933 1.0166003737087403 1.015901399103879 1.3540980003387089 1.0 11.16511106900787 -5.890391522811243 8.465104395855835 1.1136553790306287 1.0501477931961747 0.08463836455486962 0.10813630559678644 0.764388969546846 54.492922175264624 0.030283091045201008 0.0450456826742658 1.287088699269669e-06 5.890391522811243 -0.06350758583445404 ALLFVPR ddPTM_A459_Selumetinib_30min_R2 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 148.12 0.039304 5681100.0 25077.0 24451.0 27760.0 24510.0 29192.0 18726.0 16464.0 19298.0 16524.0 25536.0 False True 23683.32073118477 26326.313077643383 25973.95182280272 21171.695717891682 25524.63998020883 21305.33652229691 17229.608622797095 19354.15398504411 19829.26171913577 24798.70932950399 0.9550223125123614 1.061600131194003 1.047391276605694 0.8537418394070571 1.0292729206612852 0.8591308619819631 0.6947784416464917 0.7804500519717662 0.7996086189672834 1.0 14.597977415791478 -6.911689219414042 4.804573274635988 0.7973201710756479 0.9882902991142554 0.44306209132254526 0.0905491322189237 0.17498491627900284 7.050306816190654 0.03192512983932844 0.027965689583764206 1.2254928467061334e-07 6.911689219414042 0.19097012803860747 ALLQSS(ph)ASR ddPTM_A459_Selumetinib_30min_R2 2 ALLQSSASR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 ALLQS(0.096)S(0.904)ASR;ALLQS(0.224)S(0.776)ASR 136.49 0.0026355000000000003 23775000.0 220720.0 228080.0 242460.0 242930.0 260720.0 177312.0 178088.0 208491.0 171444.0 230350.0 True False 208453.26601216657 245573.00260721074 226860.38757048792 209842.51492237533 227966.02273362735 201735.1185219217 186369.44487467752 209097.6742924568 205737.5905456009 223699.1969788241 0.9318462865644496 1.0977822268644857 1.0141314346871038 0.9380566303161094 1.0190739431005074 0.9018142275272379 0.8331252297357138 0.9347269776397565 0.9197064331217806 1.0 17.77120055194807 -6.764945330167636 24.9179930831273 0.9084981611794811 1.0029245529567152 0.3290577126237785 0.05792776853360576 92.82392587834951 659726.8571162665 0.019918075951537446 0.01826657378201878 1.7181246544116726e-07 6.764945330167636 0.09442639177723411 ALLS(ph)PQYMVPDMDLWVPAR ddPTM_A459_Selumetinib_30min_R1 1 ALLSPQYMVPDMDLWVPAR 19 0 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 ALLS(0.963)PQY(0.037)MVPDMDLWVPAR 67.252 0.021082 11688000.0 668.3 830.24 1052.1 744.37 1001.0 770.24 906.72 784.87 574.62 857.2 True False 683.8700897145683 733.0351148318953 909.230598771624 614.379753055449 910.4597267409034 762.492084921965 838.3253803955403 764.0526979829373 975.0881714157024 967.2299698350745 0.7070398054675427 0.7578705558067927 0.9400355935276281 0.6351951161730534 0.941306364706781 0.7883255365339641 0.8667280859157889 0.7899390236152611 1.008124439715167 1.0 9.917715137280053 -5.670624493092114 0.04087731244601418 1.585218925547939 9.258350140905262e-06 0.37964067844535176 0.09525944391818209 283.945335513635 2.520890249817268 38.99762210709977 59.65376046192956 2.1348900194241433e-06 5.670624493092114 -1.585209667197798 ALLS(ph)SPEGEEK ddPTM_A459_Selumetinib_30min_R1 1 ALLSSPEGEEK 11 0 A0A499FJI4;O75592-2;O75592;H7C3U4 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 ALLS(0.989)S(0.011)PEGEEK 109.24 0.0079417 0.0 1305.7 1504.1 1242.3 1467.3 1346.5 1414.6 1354.4 1679.0 889.45 1325.3 True False 1336.1202695500706 1327.999272762881 1073.6024834654393 1211.063599632253 1224.7093127438839 1400.3704083540338 1252.2365175663049 1634.4674658393758 1509.3316871422783 1495.4151645151946 0.8934778122189455 0.8880472154322516 0.7179293810448253 0.8098510890952969 0.8189761223539069 0.9364425622954186 0.8373838565240664 1.0929857504616527 1.0093061264572607 1.0 10.546330352789148 -7.752313206335715 24.999533608491788 1.0383594561585232 0.8414449907786603 0.6800878400496702 0.059982444441370165 109.0718585587361 298785.1202417655 0.030381274463286215 0.017222898193269425 1.7688328438463546e-08 7.752313206335715 -0.1969144653798629 ALLT(ph)PVAIAAGR ddPTM_A459_Selumetinib_30min_R2 2 ALLTPVAIAAGR 12 0 P00390-5;P00390-4;P00390-2;P00390-3;P00390 P00390-5 GSR Glutathione reductase, mitochondrial 1 ALLT(1)PVAIAAGR;ALLT(1)PVAIAAGR 121.21 0.008987799999999999 11090700.0 61132.0 54850.0 58575.0 67424.0 64459.0 45942.0 47733.0 45785.0 37358.0 56640.0 True False 57734.52817078547 59056.8186294523 54806.34827163794 58240.73488711256 56361.084149228554 52270.09348004722 49952.679081145136 45918.226769885194 44830.643869733416 55004.656031606646 1.0496298374743074 1.0736694471013 0.9963947095704997 1.0588328168736554 1.024660241795576 0.9502848895193872 0.9081536488918582 0.8348061797441251 0.8150336190444121 1.0 15.747266124539493 -6.998968087402396 1.7191686660954657 0.8710128036463425 1.0444161227855977 0.6685424266061712 0.05020903832653647 0.1989323036536241 1.1865793323543383 0.022996231389746935 0.01745220725559881 1.0023788916477605e-07 6.998968087402396 0.17340331913925522 ALMDEVVK ddPTM_A459_Selumetinib_30min_R2 2 ALMDEVVK 8 0 P00558-2;P00558 P00558-2 PGK1 Phosphoglycerate kinase 1 0 ; 136.16 0.036184 4218900.0 25225.0 25355.0 29560.0 28327.0 29767.0 24231.0 27401.0 28535.0 23617.0 25022.0 False True 23823.095483675694 27299.646970825215 27658.14178249451 24468.813733199386 26027.403339643588 27568.60030288241 28675.200794051463 28618.032125776444 28341.059914114623 24299.549845036374 0.9803924614077572 1.1234630742100626 1.1382162204187576 1.006965721144731 1.0711063993212269 1.1345313176043794 1.180071276090281 1.1777186124138097 1.166320367860798 1.0 14.568641967357909 -6.792473970062986 4.741468705478408 1.1469851767480832 1.067915272095351 0.19244995207847904 0.06591652234491623 0.28694341147249597 15.222503231954642 0.022871989619333292 0.020817289932776338 1.6125976773294182e-07 6.792473970062986 -0.07906990465273211 ALMGS(ph)PQLVAAVVR ddPTM_A459_Selumetinib_30min_R1 2 ALMGSPQLVAAVVR 14 0 P14923;C9JTX4;C9J826;C9JK18;C9JKY1 P14923 JUP Junction plakoglobin 1 ALMGS(1)PQLVAAVVR;ALMGS(1)PQLVAAVVR 125.33 0.0013880999999999998 22898000.0 3723.7 4841.4 4566.6 4499.8 5247.0 3661.5 4332.7 4888.8 2232.77 4643.0 True False 3810.4549649411024 4274.5666372942005 3946.480802538256 3713.994401707362 4772.409776433091 3624.6686343760025 4005.8809507232195 4759.1331429395705 3788.847614931324 5238.97427664985 0.7273284356299152 0.8159167065098941 0.7532926474038538 0.7089163270491067 0.9109435405521571 0.6918660873238449 0.7646307729697133 0.9084093358028239 0.7232040882159411 1.0 12.35506866305753 -14.522878695749396 0.2507026193237351 2.332757278530927 0.7622780543836696 0.4473093049344493 0.07393796185464793 166.3677234410358 1.6455001873434525 113.61857621002584 0.10149770240662027 3.000000342147641e-15 14.522878695749396 -1.5704792241472576 ALMGS(ph)PQLVAAVVR ddPTM_A459_Selumetinib_30min_R2 2 ALMGSPQLVAAVVR 14 0 P14923;C9JTX4;C9J826;C9JK18;C9JKY1 P14923 JUP Junction plakoglobin 1 ALMGS(1)PQLVAAVVR;ALMGS(1)PQLVAAVVR 140.27 0.0005638 16581100.0 64479.0 36837.0 54169.0 71134.0 48436.0 40307.0 79994.0 71724.0 50182.0 42522.0 True False 60895.51530988802 39662.279450376234 50683.82551474786 61445.426487005476 42351.03665666599 45858.92337948422 83713.87950510392 71932.70496545265 60219.8022022314 41294.27937457588 1.4746719456589004 0.9604787890982197 1.227381280951786 1.4879888308412104 1.0255908880865645 1.1105393791595914 2.02725125060894 1.7419532694337383 1.4583085869106511 1.0 15.333654313989113 -7.226981844629847 24.981833185937464 1.6187079548006984 1.2073360137523945 0.2393975775517334 0.2906200942659454 720.8312134193654 522605.8592994082 0.10763264121077488 0.08336789919892794 5.929501119171623e-08 7.226981844629847 -0.4113719410483039 ALNHSVEDIEPDLLT(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ALNHSVEDIEPDLLTPR 17 0 I3L2K5;Q8IWR0 I3L2K5 ZC3H7A Zinc finger CCCH domain-containing protein 7A 1 ALNHSVEDIEPDLLT(1)PR;ALNHSVEDIEPDLLT(1)PR 207.17 7.4117e-09 13673000.0 60334.0 68295.0 75733.0 64148.0 79275.0 58444.0 49485.0 52660.0 46797.0 55333.0 True False 56980.87781613835 73533.00689696352 70860.4212318559 55410.93173852772 69315.765772508 66494.13049819085 51786.15055266726 52813.23188166772 56157.70761742903 53735.39251760045 1.0603975358973117 1.3684278359533444 1.3186917953311001 1.0311812967659715 1.2899462072377041 1.2374363968107502 0.9637251749060038 0.9828388592187043 1.0450785783138212 1.0 15.71358500389683 -7.258477075791919 24.87291684526256 0.9964805523751676 1.22393138588415 0.5315849247717783 0.10095949168210332 191.90811543329835 1611361.4608662645 0.039803116015984664 0.029468481475442888 5.5147131099343925e-08 7.258477075791919 0.22745083350898243 ALPAAHIPAPPHEGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ALPAAHIPAPPHEGSPR 17 0 P17029;E9PC66 P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 1 ALPAAHIPAPPHEGS(1)PR;ALPAAHIPAPPHEGS(1)PR 119.37 0.00078618 5883600.0 18541.1 17865.9 20650.0 16158.099999999999 21355.9 17971.4 18304.7 16661.5 17353.6 15642.1 True False 17510.65988790405 19236.157082077174 19321.401482020017 13957.338905722785 18672.980917831646 20446.797221873683 19155.904820074935 16709.982206540193 20824.80490009651 15190.471929943395 1.1527396889748442 1.2663304452153947 1.2719421470990477 0.9188219411544507 1.2292561418729555 1.346027780846561 1.2610473794638926 1.100030485135985 1.3709123058281516 1.0 13.890879071009769 -10.698860558649855 5.4992292845554855 0.9999938195055341 1.2101406255165468 0.208723099827822 0.12431096614283735 9.492825914243594e-06 1.4224981290992774e-06 0.12129234535068777 0.029416849656325617 2.0005040795242762e-11 10.698860558649855 0.21014680601101265 ALPASET(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ALPASETPK 9 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 ALPAS(0.031)ET(0.969)PK 121.36 0.014702000000000003 75079000.0 7751.8 8814.0 7812.2 6594.1 5997.9 5914.4 7451.6 6692.1 5177.5 6705.9 True False 7932.4018576229055 7782.0527824825695 6751.34614934292 5442.564221587296 5455.391004015254 5854.906505845535 6889.5198126824225 6514.603768995642 8785.839350361623 7566.667585997469 1.048334919892906 1.0284650004823368 0.8922482813751003 0.7192815277968676 0.72097669707478 0.7737760961880179 0.9105091157211471 0.8609607459235121 1.1611240021459772 1.0 12.88544235162826 -9.708708621354786 8.505164332304092 0.9999999845711064 0.8898012849946211 0.037462823713731 0.13794336101519938 0.0 0.0 0.1440402294489286 0.03493488707977273 1.9556511092252614e-10 9.708708621354786 -0.11019869957648531 ALPASET(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 ALPASETPK 9 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 ALPAS(0.294)ET(0.706)PK;ALPASET(1)PK;ALPAS(0.011)ET(0.989)PK 136.5 0.0061611 133755000.0 839860.0 830000.0 764450.0 758850.0 672420.0 577490.0 853710.0 737830.0 456473.0 678000.0 True False 793183.9434259619 893658.3311293618 715266.1192702268 655493.3209107339 587944.5880889284 657034.0055677254 893409.2065942724 739976.9631456686 547780.3549212695 658424.3783444429 1.2046697684863392 1.3572679878232887 1.0863299458454259 0.9955483765028886 0.8929568944079341 0.9978883333873306 1.356889623134369 1.1238602146024474 0.8319563687763517 1.0 19.328658227367562 -5.383470156630127 5.13733222095686 1.0405689421522573 1.2788432376554033 0.3396634197949796 0.13781185739788304 0.2673890883075867 9.982801933886984 0.03903026412645292 0.0838045825751276 4.135517313636179e-06 5.383470156630127 0.23827429550314605 ALPDSQQVPS(ph)SPASK ddPTM_A459_Selumetinib_30min_R1 2 ALPDSQQVPSSPASK 15 0 O14924-5;O14924-4;O14924;O14924-7;O14924-6;O14924-2;O14924-3 O14924-5 RGS12 Regulator of G-protein signaling 12 1 ALPDSQQVPS(0.506)S(0.494)PASK;ALPDSQQVPS(0.683)S(0.317)PASK 230.96 6.21e-14 22399000.0 12004.4 14101.5 14674.7 15171.5 13106.2 12524.6 12980.6 12611.900000000001 7313.1 10667.6 True False 12284.079163503755 12450.489824390508 12681.95634235715 12522.082329326462 11920.746524087552 12398.613895426932 12001.462891258985 12277.391442775244 12409.796572308947 12036.89037122334 1.0205359345027658 1.034360988628422 1.053590749042292 1.0403087461245866 0.9903510089770815 1.0300512435560902 0.9970567581101302 1.0199803324724857 1.0309802772630643 1.0 13.555175111725383 -6.22419116494961 24.84044342804248 1.0126173556219042 1.0381672218665867 0.42310965902756204 0.01469793243725294 531.7488122416182 354617.47965194564 0.00428875200830126 0.0055366404886694155 5.967725452644743e-07 6.22419116494961 0.025549866244682473 ALPDSQQVPSS(ph)PASK ddPTM_A459_Selumetinib_30min_R2 2 ALPDSQQVPSSPASK 15 0 O14924-5;O14924-4;O14924;O14924-7;O14924-6;O14924-2;O14924-3 O14924-5 RGS12 Regulator of G-protein signaling 12 1 ALPDSQQVPS(0.023)S(0.975)PAS(0.002)K;ALPDSQQVPS(0.001)S(0.999)PASK 284.53 1.2379999999999998e-55 29569000.0 89552.0 85037.0 96358.0 96093.0 104637.0 77671.0 81457.0 82808.0 65642.0 86230.0 True False 84575.05834505953 91559.06446294884 90158.43118665778 83004.96763032889 91491.5645933513 88369.47522286256 85244.91190398329 83048.95757039754 78772.23419072309 83740.31584755355 1.0099682272398591 1.093368988834829 1.0766430753711056 0.9912187073838683 1.092562927036347 1.0552799368912849 1.0179674036478297 0.9917440211425211 0.9406727619003171 1.0 16.353634739123244 -7.632056415556299 2.1406624004460473 0.9706125857244063 1.054831762360637 0.5041111837442815 0.033804118033206695 0.2545353466361982 2.323874189024666 0.020850957992694794 0.009856902123802518 2.3331549619880024e-08 7.632056415556299 0.08421917663623057 ALPGQLKPFETLLSQNQGGK ddPTM_A459_Selumetinib_30min_R1 2 ALPGQLKPFETLLSQNQGGK 20 1 P09211;A0A087X243 P09211 GSTP1 Glutathione S-transferase P 0 ; 168.55 7.302e-09 24974000.0 3358.2000000000003 4100.6 4764.8 4805.1 3923.3 3659.0 3225.7 3559.2 2547.69 2939.5 False True 3436.4395260802985 3620.499845682779 4117.766331172924 3965.979487898139 3568.4382077148716 3622.1937821061865 2982.3828519740323 3464.798454089047 4323.24385408456 3316.8134581546924 1.0360665649228764 1.091559682616894 1.2414826408307693 1.195719788867659 1.07586340104281 1.092070394613447 0.8991711139622786 1.0446166170637423 1.3034329209728286 1.0 11.695582160049128 -6.416842122137263 6.385190638722572 1.0625901133672147 1.1446610827907262 0.0955133378184857 0.10790411268520425 0.5918141393554894 30.64406469706493 0.035309658592078734 0.03997536862597136 3.8296393582752447e-07 6.416842122137263 0.08207096942351155 ALPLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ALPLSPR 7 0 J3KTI7;J3QR52;J3QLN7;Q99741 J3KTI7 CDC6 Cell division control protein 6 homolog 1 ALPLS(1)PR 100.02 0.020839 47121000.0 5510.2 7579.6 8009.2 8261.5 7254.6 6349.1 6379.1 6008.6 3184.1 5064.8 True False 5638.576939017228 6692.176908339558 6921.594631386461 6818.784112561751 6598.422710903658 6285.233818521559 5897.919351157129 5849.232409316543 5403.185142537217 5714.9164153297825 0.9866420659963144 1.1710017123589693 1.2111453831275407 1.1931555279217971 1.154596538490737 1.099794530968458 1.0320219794180117 1.0235027048910934 0.9454530477547541 1.0 12.480516682826941 -7.304722913548327 1.5582106155820965 0.9843758229810747 1.151548186468562 0.5668618527365957 0.05993107290376916 0.298390166763572 1.40919167026101 0.03653166446708761 0.0211449359858083 4.957663963854643e-08 7.304722913548327 0.1671723634874872 ALPLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ALPLSPR 7 0 J3KTI7;J3QR52;J3QLN7;Q99741 J3KTI7 CDC6 Cell division control protein 6 homolog 1 ALPLS(1)PR;ALPLS(1)PR 80.455 0.04486 50147000.0 74044.0 67657.0 78925.0 78884.0 81167.0 59049.0 64874.0 61948.0 55992.0 72245.0 True False 69928.93090161683 72846.074348457 73847.05142704278 68139.86311750993 70970.07581781343 67182.46375654769 67890.76954539238 62128.25842395653 67191.96454719492 70159.09913494738 0.9967193388146585 1.0382983140695887 1.0525655593866994 0.9712191855036001 1.011559109122912 0.9575730672841981 0.9676687754329345 0.8855338678801457 0.957708485081239 1.0 16.098342602789792 -6.635741482285003 1.1656483123078951 0.9422122858298854 1.0245665657763288 0.4324790229509484 0.033977181588341204 0.3898606396818151 1.122611213185144 0.0162127234290635 0.016517168065753127 2.3134414773377608e-07 6.635741482285003 0.0823542799464434 ALPNNTS(ph)SSPQPK ddPTM_A459_Selumetinib_30min_R1 1 ALPNNTSSSPQPK 13 0 A0A087WXZ1;A0A087WT22;E7ESS1;A0A087X1Q1;J3KP33;A0A087WZU8;A0A0U1RQC9;P04637-8;P04637-9;P04637-7;P04637-5;P04637-6;P04637-2;P04637-3;P04637-4;P04637 A0A087WXZ1 TP53 Cellular tumor antigen p53 1 ALPNNT(0.233)S(0.414)S(0.176)S(0.176)PQPK 145.81 0.00061704 30031000.0 10188.0 11257.0 11777.0 11849.0 10349.0 9575.9 9714.8 9413.9 5403.8 8993.4 True False 10425.360577602902 9939.025206762679 10177.748086430398 9779.794583277146 9412.934777264345 9479.575140221541 8982.004814569653 9164.212791343247 9169.853922063574 10147.790493134351 1.027352760648374 0.9794275131603362 1.0029521296597832 0.9637363512671868 0.9275846583187558 0.9341516408557211 0.8851192602612924 0.9030746937023819 0.9036305911387887 1.0 13.308878019117527 -6.063156562373021 1.4423333935092433 0.9160562483962024 1.0053765699193047 0.5477443059251179 0.031243536349556216 0.28205366400722753 1.1839309431809775 0.010669008703927375 0.017768045547007803 8.646561556082213e-07 6.063156562373021 0.08932032152310232 ALPNNTS(ph)SSPQPK ddPTM_A459_Selumetinib_30min_R2 1 ALPNNTSSSPQPK 13 0 A0A087WXZ1;A0A087WT22;E7ESS1;A0A087X1Q1;J3KP33;A0A087WZU8;A0A0U1RQC9;P04637-8;P04637-9;P04637-7;P04637-5;P04637-6;P04637-2;P04637-3;P04637-4;P04637 A0A087WXZ1 TP53 Cellular tumor antigen p53 1 ALPNNT(0.059)S(0.705)S(0.215)S(0.02)PQPK 206.45 1.2293e-05 6222800.0 37222.0 32963.0 39130.0 43015.0 43071.0 28391.0 30634.0 32770.0 33141.0 35787.0 True False 35153.35025147186 35491.15610724953 36612.41840152268 37156.28279498616 37660.03592037455 32301.602542162324 32058.54170011943 32865.35527463446 39770.12603690868 34753.7363242074 1.0114984450459248 1.0212184317727153 1.0534815036857097 1.0691305950061343 1.0836255293259733 0.9294425854195981 0.9224487807887678 0.9456639415124524 1.1443410189311691 1.0 15.084880467792471 -6.753185113288802 24.994337108468205 0.9808626038888575 1.0478163327955143 0.1828165600128372 0.06179135202117234 302.6827358453865 916536.6931686043 0.021239138018048775 0.020890982906461672 1.7652852267200094e-07 6.753185113288802 0.06695372890665685 ALPNNTSS(ph)SPQPK ddPTM_A459_Selumetinib_30min_R1 1 ALPNNTSSSPQPK 13 0 A0A087WXZ1;A0A087WT22;E7ESS1;A0A087X1Q1;J3KP33;A0A087WZU8;A0A0U1RQC9;P04637-8;P04637-9;P04637-7;P04637-5;P04637-6;P04637-2;P04637-3;P04637-4;P04637 A0A087WXZ1 TP53 Cellular tumor antigen p53 1 ALPNNT(0.018)S(0.036)S(0.473)S(0.473)PQPK 190.03 0.00016069 40297000.0 7870.3 8572.5 9543.8 9296.2 7257.9 6930.4 7819.4 7355.0 4459.5 6376.8 True False 8053.662677062049 7568.827714752873 8247.804380340865 7672.793181286268 6601.424226486322 6860.686468299729 7229.5763625649415 7159.921507592981 7567.445791006789 7195.324395292007 1.1192911166495376 1.051909170308604 1.146272763704373 1.0663582014879935 0.9174602650028842 0.9534923085314632 1.004760308971663 0.9950797370967471 1.0517171117341515 1.0 12.81284401581517 -6.046953402231699 7.7736658308891 0.9863409945727976 1.1014840073724108 0.6561744088656444 0.039350774265454906 0.17946181955448726 26.97034120615172 0.01193927007823713 0.015616830809676636 8.975250895823195e-07 6.046953402231699 0.11514301279961325 ALPNNTSS(ph)SPQPK ddPTM_A459_Selumetinib_30min_R2 1 ALPNNTSSSPQPK 13 0 A0A087WXZ1;A0A087WT22;E7ESS1;A0A087X1Q1;J3KP33;A0A087WZU8;A0A0U1RQC9;P04637-8;P04637-9;P04637-7;P04637-5;P04637-6;P04637-2;P04637-3;P04637-4;P04637 A0A087WXZ1 TP53 Cellular tumor antigen p53 1 ALPNNT(0.011)S(0.125)S(0.432)S(0.432)PQPK 190.57 0.00016479 64699000.0 54916.0 52726.0 55878.0 62662.0 61611.0 43088.0 52247.0 57579.0 46219.0 54391.0 True False 51863.988566165914 56769.91465918876 52282.87031536636 54127.32750202074 53870.87537067157 49022.98088607975 54676.58902546646 57746.5453572834 55464.09146675965 52820.590505210384 0.9818896015759213 1.074768648290458 0.9898198754557471 1.024739159186065 1.0198840046166766 0.9281036129507861 1.035137784384917 1.0932582314010122 1.0500467892589824 1.0 15.68881280968332 -7.5165761488022635 24.940598837526075 1.055831113999152 1.0054194915357382 0.19348083533343785 0.04088751262208984 419.11447761126595 1658536.9993575679 0.01840018985203497 0.011089230963470966 3.043854236576923e-08 7.5165761488022635 -0.05041162246341391 ALPNNTSSS(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 2 ALPNNTSSSPQPK 13 0 A0A087WXZ1;A0A087WT22;E7ESS1;A0A087X1Q1;J3KP33;A0A087WZU8;A0A0U1RQC9;P04637-8;P04637-9;P04637-7;P04637-5;P04637-6;P04637-2;P04637-3;P04637-4;P04637 A0A087WXZ1 TP53 Cellular tumor antigen p53 1 ALPNNTS(0.008)S(0.081)S(0.911)PQPK;ALPNNT(0.024)S(0.032)S(0.094)S(0.851)PQPK 195.71 0.00020262 70368000.0 25954.4 27750.1 29173.7 29430.2 26471.0 24063.9 26029.9 24018.3 13790.1 20091.4 True False 26559.08702152895 24501.10539132851 25212.071779663278 24290.7680432748 24076.70272383462 23821.83901427305 24066.443686207294 23381.256661566338 23400.792510945786 22670.32689680871 1.1715352470399383 1.080756598828644 1.1121176988062031 1.0714785081768803 1.0620359747535835 1.0507938029612813 1.0615834432275044 1.0313594844923786 1.0322212210464377 1.0 14.468517573848464 -1.522878745280391 0.20899143571240575 1.0053417099581337 1.7199941230139342 0.8480073508680818 0.017633008637319616 18.701855713584006 0.23213769677071586 0.028534089492175837 4.435543090471211 0.029999999999996314 1.522878745280391 0.7146524130558005 ALPNNTSSS(ph)PQPK ddPTM_A459_Selumetinib_30min_R2 4 ALPNNTSSSPQPK 13 0 A0A087WXZ1;A0A087WT22;E7ESS1;A0A087X1Q1;J3KP33;A0A087WZU8;A0A0U1RQC9;P04637-8;P04637-9;P04637-7;P04637-5;P04637-6;P04637-2;P04637-3;P04637-4;P04637 A0A087WXZ1 TP53 Cellular tumor antigen p53 1 ALPNNT(0.002)S(0.008)S(0.027)S(0.964)PQPK;ALPNNT(0.011)S(0.047)S(0.018)S(0.924)PQPK;ALPNNT(0.041)S(0.02)S(0.01)S(0.928)PQPK;ALPNNT(0.003)S(0.006)S(0.003)S(0.987)PQPK 192.39 0.00012286 112464800.0 236689.0 219171.0 252924.0 266811.0 279935.0 198275.0 212678.0 227842.0 211624.0 239344.0 True False 223534.7729211385 235980.71095415996 236651.14520282947 230470.88152535277 244767.0626493478 225585.5814887548 222567.94841346197 228504.98249872663 253954.7132686031 232433.51682960574 0.9617148850568277 1.0152611128245959 1.0181455257862644 0.9915561433177825 1.0530626821293747 0.9705380900557854 0.9575553106509329 0.9830982451048182 1.092590762006042 1.0 17.82645859428655 -8.233330817200454 24.97307977533997 1.0462954201812007 0.9952971593115955 0.26958053059943576 0.03445580670261475 834.5264868792236 741437.9701150724 0.02320701514153308 0.008768380909548328 5.8434479882961614e-09 8.233330817200454 -0.05099826086960524 ALPPLPRPPT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ALPPLPRPPTPK 12 1 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 ALPPLPRPPT(1)PK 86.344 0.041552 51984000.0 561030.0 400880.0 492280.0 459570.0 477740.0 330600.0 400450.0 413980.0 301540.0 394680.0 True False 529850.1985810337 431626.2069676353 460607.24075393745 396975.7731975311 417722.03015021107 376137.1491120026 419071.71847662184 415184.6132619215 361856.4257315543 383284.56289820705 1.3823937874632108 1.1261246831959337 1.2017369999747833 1.035720745432057 1.0898483022420862 0.9813522002238773 1.0933696763256264 1.0832281115693838 0.9440933988976131 1.0 18.54805636801305 -1.522878745281053 0.5395205622028659 1.0265240381280576 14.825130608972499 0.7560521997109882 0.059132775587998794 61.554337217302106 0.5825737690952597 0.028534816939853314 980.1441774662078 0.029999999999950577 1.522878745281053 13.798606570844441 ALPQTPRPR ddPTM_A459_Selumetinib_30min_R1 1 ALPQTPRPR 9 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 115.71 0.0068507 0.0 424.93 344.48 501.82 516.91 410.47 437.56 353.74 300.94 223.11 171.88 False True 434.83004223015337 304.14812145559296 433.67560029994894 426.6413721024383 373.34306097436433 433.15854367269293 327.0571070022923 292.9580936091137 378.60137469032975 193.9424722529779 2.2420568180803766 1.5682388592987677 2.2361043213590883 2.199834657907881 1.9250196031706606 2.23343829044152 1.6863614411168284 1.510541194024691 1.9521323529200114 1.0 7.599484969490082 -9.155564271946822 0.42323659019560295 0.906398691624421 2.0710285498082954 0.5945726703440324 0.2492106436965104 1.8927913224121207 0.5813012434872754 0.6204561675274242 0.1668074334703545 6.989332928328213e-10 9.155564271946822 1.1646298581838743 ALPQTPRPR ddPTM_A459_Selumetinib_30min_R2 1 ALPQTPRPR 9 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 104.01 0.041498 4432500.0 6664.3 6021.8 6239.4 7410.7 8277.0 6879.3 4514.7 5489.0 4175.6 5095.6 False True 6293.924885306642 6483.652696861182 5837.963796945069 6401.349875829447 7237.16926268116 7826.861130932237 4724.6424957083345 5504.972081247135 5010.836676012068 4948.47678804122 1.2718913627152726 1.3102320117030677 1.1797496577236526 1.293600061194452 1.4625044377637435 1.5816707779345534 0.954767031973593 1.112457897054458 1.0126018349972967 1.0 12.27276879601189 -7.281626817184078 24.99876791726662 1.029328159193875 1.342955971413453 0.6846406890301808 0.10958093837618683 563.0427788632179 697231.4268766626 0.05039883737260153 0.03402522708113026 5.228452692234269e-08 7.281626817184078 0.3136278122195779 ALPS(ph)EDEEGQDDKDFYLR ddPTM_A459_Selumetinib_30min_R1 2 ALPSEDEEGQDDKDFYLR 18 1 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2;A0A5F9ZHE1;A0A5F9ZH87;H0Y325;F8WAI0;Q5JV20;Q8NF91-9;H0Y326;Q8NF91-3;Q8NF91-11;Q8NF91-8;A0A5F9ZHB2;A0A5F9ZH86 Q8NF91 SYNE1 Nesprin-1 1 ALPS(1)EDEEGQDDKDFYLR;ALPS(0.999)EDEEGQDDKDFY(0.001)LR 88.98299999999998 0.0034625 45245000.0 2690.3999999999996 3055.5 2937.1 3308.0 2789.1000000000004 2502.7 3062.5 2691.9 1895.94 2578.8999999999996 True False 2753.081085392898 2697.7606395365883 2538.2579523354593 2730.3198988506056 2536.8263974556007 2477.525110269787 2831.493159367103 2620.5020674764846 3217.2717060211703 2909.9269356132463 0.9460997290685258 0.9270887892475742 0.872275492992933 0.9382778190873065 0.8717835373832101 0.8514045765027658 0.9730461355279307 0.9005387851513985 1.1056194114864102 1.0 11.50676721410088 -8.250350824571589 24.89359438922891 1.0528097050883944 0.9091806931247766 0.6396848070014067 0.04284879212232665 355.59372737980266 798305.8991751155 0.0287791904358044 0.010644822701970676 5.618872473672098e-09 8.250350824571589 -0.14362901196361788 ALPS(ph)EDEEGQDDKDFYLR ddPTM_A459_Selumetinib_30min_R2 3 ALPSEDEEGQDDKDFYLR 18 1 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2;A0A5F9ZHE1;A0A5F9ZH87;H0Y325;F8WAI0;Q5JV20;Q8NF91-9;H0Y326;Q8NF91-3;Q8NF91-11;Q8NF91-8;A0A5F9ZHB2;A0A5F9ZH86 Q8NF91 SYNE1 Nesprin-1 1 ALPS(1)EDEEGQDDKDFYLR;ALPS(0.998)EDEEGQDDKDFY(0.002)LR;ALPS(1)EDEEGQDDKDFYLR 82.859 0.0050838 26238900.0 73972.0 50491.0 64717.0 72584.0 55925.0 40900.2 84175.0 64183.0 59859.0 57381.0 True False 69860.93237337796 54363.49734584642 60553.17867854188 62697.93398561597 48899.201524156546 46533.831294950774 88089.3042895981 64369.76190393236 71832.47260020264 55724.26143625738 1.253689695883927 0.9755804015102555 1.086657357456559 1.1251460740728836 0.8775208547194838 0.8350730919633725 1.5808070312490887 1.155147869973378 1.2890699804495631 1.0 15.766017969826581 -7.242316900599504 24.987441617752253 1.2691852716187793 1.023904883542081 0.2910103387368743 0.1758916016481177 991.4269716366165 1295504.6479883092 0.06598897709718848 0.05103166511988826 5.7237821956344725e-08 7.242316900599504 -0.24528038807669827 ALPSLNTGSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 ALPSLNTGSSSPR 13 0 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 ALPSLNT(0.001)GS(0.047)S(0.16)S(0.793)PR;ALPSLNTGSS(0.025)S(0.975)PR;ALPSLNTGSS(0.003)S(0.997)PR;ALPSLNTGSS(0.028)S(0.972)PR;ALPSLNTGSS(0.006)S(0.994)PR;ALPSLNTGSS(0.008)S(0.992)PR 255.39 1.1154999999999997e-23 777030000.0 18609.7 20131.6 21825.1 21885.7 19939.0 17594.5 18129.2 17528.9 10151.199999999999 14542.2 True False 19043.269801827333 17774.582913073067 18861.37129669288 18063.773340469965 18135.520970516372 17417.51530452781 16761.699848097345 17063.976630108307 17225.844985686308 16408.833023023355 1.1605499169323974 1.0832326033261122 1.1494645152539702 1.100856673666223 1.1052291741326326 1.0614719084586433 1.0215046874192015 1.0399262766685307 1.0497909852282974 1.0 14.002185019268646 -6.794915941115918 1.550445854371055 1.0294531414250507 1.1237878878733123 0.7746314044404539 0.02373688038819968 0.17895436830591163 0.8930324227102956 0.01008123355087123 0.008903889525573718 1.60355573325061e-07 6.794915941115918 0.09433474644826156 ALPSLNTGSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 ALPSLNTGSSSPR 13 0 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 ALPSLNTGS(0.003)S(0.031)S(0.967)PR;ALPSLNT(0.009)GS(0.009)S(0.118)S(0.865)PR;ALPSLNTGSS(0.001)S(0.999)PR;ALPSLNTGS(0.002)S(0.078)S(0.92)PR;ALPSLNTGS(0.003)S(0.034)S(0.963)PR;ALPSLNTGS(0.01)S(0.034)S(0.956)PR 201.72 8.953e-05 656421900.0 1276912.0 1235285.0 1235016.0 1405337.0 1384637.0 973479.0 990522.0 1048922.0 955758.0 1169395.0 True False 1205946.3429237383 1330027.3874326914 1155556.4151437532 1213927.6762584562 1210686.5212481625 1107566.8958874866 1036583.2356821066 1051974.1893616156 1146936.306109767 1135631.5278969056 1.0619169275416735 1.1711786391628196 1.0175452043707758 1.0689450287687492 1.0660909736191038 0.9752872024772047 0.9127813117356577 0.9263340824200114 1.0099546181443173 1.0 20.11506337678295 -6.772263446053373 3.507682781421717 0.9544985560122031 1.0805541399395697 0.6073907470561186 0.045139055226932755 0.15340557473880648 3.9892226729848583 0.016428324066504855 0.015212779431851516 1.6894158093711839e-07 6.772263446053373 0.1260555839273666 ALPTSKPEGSLHS(ph)SPVGPSSSK ddPTM_A459_Selumetinib_30min_R1 2 ALPTSKPEGSLHSSPVGPSSSK 22 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 ALPTSKPEGSLHS(0.867)S(0.132)PVGPSSSK;ALPTSKPEGSLHS(0.904)S(0.095)PVGPSSSK 140.07 5.0371e-06 69677000.0 7261.6 7899.5 8632.6 9058.6 11228.8 7840.400000000001 11503.400000000001 8403.9 1947.9099999999999 5550.5 True False 7430.781151386062 6974.62286762208 7460.3403354775455 7476.685560981886 10213.157022605654 7761.532694513619 10635.689276559533 8181.001272285606 3305.461000282552 6262.96074144842 1.1864645904945532 1.1136303029115069 1.1911842726563555 1.1937940966963128 1.6307234619905475 1.2392753227954336 1.6981887186634101 1.306251405687976 0.5277792942891905 1.0 12.61262912028764 -8.243277252759244 23.423620864499444 0.7638897886096063 1.3248445059402245 0.5230591361569611 0.21234678338897764 244.56766098456583 315420.0231581512 0.14723759539728834 0.05533920876073017 5.711139222418069e-09 8.243277252759244 0.5609547173306182 ALPTSKPEGSLHS(ph)SPVGPSSSK ddPTM_A459_Selumetinib_30min_R2 2 ALPTSKPEGSLHSSPVGPSSSK 22 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 ALPTSKPEGSLHS(0.571)S(0.426)PVGPS(0.002)S(0.001)S(0.001)K;ALPTSKPEGSLHS(0.886)S(0.114)PVGPSSSK 159.98 2.0637e-09 106659000.0 204650.0 167139.0 277298.0 347370.0 356400.0 246890.0 232899.0 253828.0 231665.0 306370.0 True False 193276.37227885978 179958.02386340965 259456.94857923427 300057.6067533267 311625.84574357455 280896.85645572364 243729.26498061366 254566.59745651248 278004.47326092876 297524.30205514334 0.6496154127370671 0.6048515116928368 0.8720529610086989 1.0085146143716148 1.0473962751648356 0.9441139917493598 0.8191911158082164 0.8556161486577689 0.9343924894222699 1.0 18.182647988311224 -5.343253470346604 4.034660653894776 0.9372151348793535 0.625431833124921 0.7795106931256713 0.06619554232843938 0.10816424734918847 3.259028786424513 0.02010841662726454 0.046254484392664094 4.536767568065254e-06 5.343253470346604 -0.3117833017544325 ALPTSKPEGSLHSS(ph)PVGPSSSK ddPTM_A459_Selumetinib_30min_R2 1 ALPTSKPEGSLHSSPVGPSSSK 22 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 ALPT(0.001)S(0.001)KPEGS(0.004)LHS(0.213)S(0.78)PVGPS(0.001)S(0.001)SK 52.432 0.016471 80668000.0 154690.0 142000.0 218710.0 269290.0 282480.0 180040.0 161160.0 187510.0 180980.0 240880.0 True False 146092.94907313364 152890.94339803513 204638.43671344357 232612.2374488393 246992.33699675888 204838.8757596033 168654.2593324815 188055.62305604827 217181.05700370352 233925.1685185986 0.6245285618401437 0.6535891129896922 0.8748029893892049 0.9943873885906599 1.0558604641001739 0.8756598405242455 0.7209752605952376 0.8039135944497422 0.9284210774713461 1.0 17.835687567181175 -5.265239960342627 4.24798279760006 0.9020816728396268 0.6319000548506772 0.5739270842144387 0.09259571838528113 0.1600587620198382 7.3203044384792 0.027670738204853815 0.07042883151386699 5.429502527801843e-06 5.265239960342627 -0.2701816179889496 ALQAPHS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 ALQAPHSPSK 10 0 F2Z2Z8;Q5T173;Q96AQ6-3;Q96AQ6-2;Q96AQ6 F2Z2Z8 PBXIP1 Pre-B-cell leukemia transcription factor-interacting protein 1 1 ALQAPHS(0.907)PS(0.093)K 77.89399999999998 0.035637 1632100.0 31856.0 15801.0 25680.0 23129.0 20479.0 20280.0 38624.0 33497.0 27018.0 20592.0 True False 30085.571049671875 17012.88589177715 24027.77675826995 19978.790300249555 17906.24493541712 23073.385916489442 40420.09253200408 33594.470724273124 32422.35494599436 19997.455455558673 1.5044699620175435 0.8507525334703568 1.2015417067270413 0.9990666234836428 0.8954261693549485 1.1538160926407142 2.021261786122321 1.6799372699657598 1.621324023851342 1.0 14.287528817789834 -7.107062003227921 7.520535035053182 1.6355733386078652 1.0729468904184218 0.39092067222096727 0.2905727220395626 0.23898650502401766 14.93377053194857 0.10523500728905177 0.08150475218106512 7.815162213433343e-08 7.107062003227921 -0.5626264481894434 ALQAS(ph)ALK ddPTM_A459_Selumetinib_30min_R2 4 ALQASALK 8 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 ALQAS(1)ALK;ALQAS(1)ALK;ALQAS(1)ALK;ALQAS(1)ALK 106.4 0.013744 34647400.0 227064.0 223782.0 215760.0 211050.0 221114.0 174183.0 204346.0 185639.0 170719.0 226897.0 True False 214444.69188921078 240945.3598274591 201878.23650172562 182304.62591844334 193335.68253575932 198175.1271741558 213848.4939039174 186179.17875580906 204867.57028740848 220345.89406079525 0.9732184609260008 1.0934869508436598 0.9161878752595487 0.8273565826833332 0.8774190386430183 0.8993819831263914 0.9705127241668268 0.8449405401874232 0.9297544261518385 1.0 17.749410488032787 -5.363609303601675 6.51995705895939 0.8997015540191395 1.0324661431799376 0.4349040692856848 0.05660315706046655 0.18283132044016293 9.83619198661717 0.014262322261964788 0.030070303965901386 4.3290310060845335e-06 5.363609303601675 0.13276458916079803 ALQEGEGDLSIS(ph)ADR ddPTM_A459_Selumetinib_30min_R1 2 ALQEGEGDLSISADR 15 0 P49589-3;B4DKY1;P49589-2;P49589 P49589-3 CARS Cysteine--tRNA ligase, cytoplasmic 1 ALQEGEGDLSIS(1)ADR;ALQEGEGDLSIS(1)ADR 231.06 6.0817e-14 16418300.0 4957.6 6493.799999999999 4543.4 3673.5 5117.299999999999 4416.4 6024.6 5774.7 2793.88 5637.799999999999 True False 5073.102434189649 5733.502877114284 3926.431235109776 3031.9921851353383 4654.441118532693 4371.975025770362 5570.159571566711 5621.536197130822 4741.010303078385 6361.4665468224275 0.7974737266713569 0.9012863362424167 0.6172210772798987 0.4766184279707999 0.7316616513306354 0.6872589824360826 0.8756093473994645 0.883685570890693 0.7452700203927873 1.0 12.635143681606865 -7.261815985726347 24.998583505703582 0.866448373058939 0.6982430916543403 0.33940755433837755 0.11869880533325405 46.75070293926527 3103090.3853779254 0.051435352682945905 0.03714023942959806 5.4724778732941815e-08 7.261815985726347 -0.16820528140459867 ALQEGEGDLSIS(ph)ADR ddPTM_A459_Selumetinib_30min_R2 2 ALQEGEGDLSISADR 15 0 P49589-3;B4DKY1;P49589-2;P49589 P49589-3 CARS Cysteine--tRNA ligase, cytoplasmic 1 ALQEGEGDLS(0.001)IS(0.999)ADR;ALQEGEGDLS(0.001)IS(0.999)ADR 194.05 3.1913000000000004e-05 14439900.0 32284.0 26459.9 33809.0 36604.0 37118.0 30283.0 33558.0 38335.0 33864.0 24077.3 True False 30489.784523091654 28489.28924801176 31633.76574845592 31618.47205457798 32454.905000869792 34454.20836829634 35118.51349391548 38446.54850329911 40637.74623921655 23382.12578866177 1.3039782951589654 1.2184216912316204 1.3529037536781814 1.3522496773971722 1.388021999976046 1.473527628741247 1.5019384384179817 1.644270878139841 1.7379833898131793 1.0 14.513118478167689 -6.430960602135139 1.1660630159104997 1.5220629172602742 1.2810384700605093 0.13172639394180163 0.18553590268963058 0.7252917180967465 2.0613652002547664 0.07951266683292146 0.09892554286870309 3.707143503273271e-07 6.430960602135139 -0.2410244471997649 ALQEGEGDLSIS(ph)ADRLSEK ddPTM_A459_Selumetinib_30min_R2 2 ALQEGEGDLSISADRLSEK 19 1 P49589-3;B4DKY1;P49589-2;P49589 P49589-3 CARS Cysteine--tRNA ligase, cytoplasmic 1 ALQEGEGDLS(0.006)IS(0.967)ADRLS(0.028)EK;ALQEGEGDLS(0.071)IS(0.922)ADRLS(0.007)EK 96.504 0.00089604 23493000.0 73354.0 64534.0 74452.0 82110.0 86135.0 50571.0 50953.0 46721.0 38310.0 66261.0 True False 69277.27833932803 69483.55029048456 69661.83937720845 70926.47635234961 75313.95124332988 57536.69621216903 53322.4154614541 46856.950374922104 45973.07047083589 64347.872763246574 1.0766055716281109 1.079811146922192 1.0825818536925598 1.1022349816179242 1.1704186635730836 0.8941507114596045 0.8286585581102556 0.7281818087028555 0.7144458471841547 1.0 15.973604835615602 -6.930887402321013 3.8121860278597217 0.8006864780373458 1.0994406290196193 0.7513012147072814 0.07791711191258531 0.10663202788177722 3.1037209058409627 0.028741086382317583 0.024719088030613724 1.1724993150437948e-07 6.930887402321013 0.2987541509822734 ALQESATGQPEPT(ph)SSPDNKPFK ddPTM_A459_Selumetinib_30min_R1 1 ALQESATGQPEPTSSPDNKPFK 22 1 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ALQES(0.006)AT(0.037)GQPEPT(0.404)S(0.311)S(0.242)PDNKPFK 80.132 0.0016820999999999993 9479900.0 2055.0 1290.8 1615.6 1625.6 1526.3 1110.2 1392.3 2152.8 1426.3 1904.1 True False 2102.8775016660743 1139.672535923361 1396.2103938555613 1341.7194762912766 1388.246434490151 1099.032395980947 1287.2776900528393 2095.700750720077 2420.3269271696336 2148.509782504626 0.9787609620351108 0.5304479156686861 0.6498506105138272 0.624488418538717 0.6461438741376371 0.5115324142018798 0.599149094193183 0.9754206230688013 1.1265142690428604 1.0 11.069120630607442 -7.837288508467515 4.602195969835623 1.0570359946477659 0.637648069947594 0.6691631117300813 0.12466763695865725 0.11739974931282772 4.578511412766574 0.06925967563114857 0.03232183093567447 1.4544925179380222e-08 7.837288508467515 -0.41938792470017183 ALQESATGQPEPT(ph)SSPDNKPFK ddPTM_A459_Selumetinib_30min_R2 1 ALQESATGQPEPTSSPDNKPFK 22 1 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ALQESATGQPEPT(0.333)S(0.333)S(0.333)PDNKPFK 88.036 0.00070878 10757000.0 42605.0 37797.0 43473.0 45253.0 33886.0 29368.0 40028.0 36859.0 31637.0 37043.0 True False 40237.18466132817 40695.9083634897 40675.99450982356 39089.463334220774 29628.937735316395 33413.17542383933 41889.38131397728 36966.253587664076 37965.28401163752 35973.47234072748 1.118523791092958 1.131275512634228 1.1307219421176673 1.0866191332318376 0.8236329663892885 0.9288281961597158 1.1644519860973246 1.027597592957759 1.0553689021744783 1.0 15.13464580193538 -6.0143537277167765 24.7867513430583 1.0013985821476792 1.1241817247425347 0.3355385222425402 0.08196324525940125 777.0897177303588 1341921.3701109986 0.026099773362406417 0.035087864440029856 9.67489526490564e-07 6.0143537277167765 0.12278314259485557 ALQESATGQPEPTS(ph)SPDNKPFK ddPTM_A459_Selumetinib_30min_R2 1 ALQESATGQPEPTSSPDNKPFK 22 1 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ALQESATGQPEPT(0.031)S(0.631)S(0.337)PDNKPFK 88.573 0.00026857 6607900.0 59288.0 51202.0 48740.0 58135.0 49697.0 37500.0 50545.0 50769.0 42684.0 46322.0 True False 55993.01030866862 55129.02875962113 45604.12146409956 50216.91271153129 43453.61856318296 42665.284608893206 52895.442653017395 50916.72938473961 51221.99269060707 44984.56350099016 1.244716097054852 1.2255099187170657 1.0137726792235244 1.116314326589519 0.9659673270415639 0.9484427832217177 1.1758576395179006 1.1318711447232088 1.138657101551727 1.0 15.45714240363293 -5.24609331456025 21.010303426769415 1.064682239894036 1.2351134622651723 0.46610230791739216 0.07431603788325986 94.42420905637474 129269.73373340463 0.020289582426101287 0.052947728795403236 5.674226731983683e-06 5.24609331456025 0.17043122237113617 ALQESATGQPEPTSS(ph)PDNKPFK ddPTM_A459_Selumetinib_30min_R2 1 ALQESATGQPEPTSSPDNKPFK 22 1 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ALQESATGQPEPT(0.021)S(0.257)S(0.723)PDNKPFK 113.52 2.0646e-05 9915200.0 34762.0 31269.0 31693.0 34503.0 25098.0 25784.0 28317.0 31311.0 21700.0 28602.0 True False 32830.06720331158 33667.23175431805 29653.90688472931 29803.631879005163 21944.964861033175 29335.511956152048 29633.79660907102 31402.10982618491 26040.606348659312 27776.185943079327 1.1819501522127256 1.212089803233281 1.0676018278930708 1.0729922365900273 0.7900640104442039 1.0561389535722503 1.0668778164791388 1.1305407405658952 0.9375155538641384 1.0 14.761560890359965 -5.457994323737135 2.2555954608326676 1.0082449200248393 1.200556151555559 0.417365181844515 0.08836765764341754 0.3257033698360741 3.2053060560569313 0.026341434723429785 0.06942408826215035 3.483418678617318e-06 5.457994323737135 0.1923112315307196 ALQEVGSGGTLGLSS(ph)PKS ddPTM_A459_Selumetinib_30min_R1 2 ALQEVGSGGTLGLSSPKS 18 1 A0A0M3HER3 A0A0M3HER3 1 ALQEVGSGGTLGLS(0.033)S(0.896)PKS(0.071);ALQEVGSGGTLGLS(0.02)S(0.972)PKS(0.008) 210.2 2.1501e-11 30962000.0 4240.9 5273.9 6156.3 6309.4 4856.9 4814.0 4208.1 3955.0 3038.5 3966.8999999999996 True False 4339.704718645086 4656.429336230406 5320.308274135304 5207.581732106409 4417.594252555339 4765.575530762278 3890.679629039254 3850.1005523494514 5156.112576740471 4476.090255878159 0.9695302084103495 1.0402894200168147 1.1886061205196852 1.16342196747879 0.9869314513383637 1.0646736902822629 0.8692138465996919 0.8601481052115435 1.1519232817008733 1.0 12.128023411770636 -6.7181395212561466 2.0321368310366017 0.9649808104823336 1.0892781033695267 0.17152451902739418 0.09980831169426459 0.5067481236369447 4.305841655981911 0.04059305788954869 0.038420197879415974 1.913641050768565e-07 6.7181395212561466 0.12429729288719304 ALQEVGSGGTLGLSS(ph)PKS ddPTM_A459_Selumetinib_30min_R2 4 ALQEVGSGGTLGLSSPKS 18 1 A0A0M3HER3 A0A0M3HER3 1 ALQEVGSGGTLGLS(0.234)S(0.766)PKS;ALQEVGSGGTLGLS(0.201)S(0.799)PKS;ALQEVGSGGTLGLS(0.035)S(0.965)PKS;ALQEVGSGGTLGLS(0.01)S(0.989)PKS 201.9 2.2061e-10 16610500.0 170145.0 166586.0 157357.0 161169.0 168489.0 125650.0 129438.0 140310.0 104099.0 170145.0 True False 160689.02204440048 179362.61054158554 147232.82193734712 139217.5041679673 147321.9055092285 142957.1469628648 135457.12347653133 140718.2788704292 124921.70876908247 165232.47176019984 0.9725026826301235 1.0855167185412116 0.891064694299463 0.8425553566130283 0.8916038351289403 0.8651879708628761 0.819797234971579 0.8516381639236879 0.7560360711082265 1.0 17.334137709886043 -5.395586689435905 4.920965007407107 0.855354852295416 1.0274346412667168 0.5193149937540966 0.06345781873673553 0.15122572362531078 5.343899390664218 0.015815687186557903 0.034053327659184354 4.021733702388985e-06 5.395586689435905 0.17207978897130083 ALQLEEER ddPTM_A459_Selumetinib_30min_R2 1 ALQLEEER 8 0 P15311;E7EQR4 P15311 EZR Ezrin 0 136.27 0.036085 11186000.0 39782.0 40587.0 43540.0 42683.0 42112.0 36043.0 39122.0 36712.0 34646.0 41118.0 False True 37571.07569996379 43699.892392225745 40738.683802767635 36869.50176771808 36821.51407394333 41007.596084222336 40941.25051877234 36818.82584200125 41576.16809012214 39930.816502605936 0.9409042686996358 1.0943901532635536 1.0202316749548304 0.9233345319976597 0.9221327610854215 1.0269661298197128 1.0253046169516833 0.9220654388471723 1.0412050574375014 1.0 15.285214951951588 -5.553736150011157 24.70606524927445 0.9778100087668257 1.0275632004505952 0.0861749544942273 0.055076303960339114 329.9022303493269 264135.4563135448 0.014793108083027742 0.02562268747261872 2.7942409305578215e-06 5.553736150011157 0.04975319168376957 ALQLS(ph)NSPGASSAFLK ddPTM_A459_Selumetinib_30min_R1 1 ALQLSNSPGASSAFLK 16 0 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 ALQLS(0.882)NS(0.11)PGAS(0.006)S(0.002)AFLK 167.18 1.5177e-05 113270000.0 3105.1 3603.6 3335.7 3386.5 2946.5 2775.8 3259.7 2892.1 1454.3 2577.2 True False 3177.4427885271666 3181.6888367318097 2882.7302616885327 2795.1113474781046 2679.9895952468264 2747.8779722247486 3013.8182046004754 2815.3921131352354 2467.840882130548 2908.0087240538423 1.0926524264678703 1.0941125487053045 0.9913072948659966 0.9611770846346169 0.9215892555889065 0.9449345696577323 1.0363855444006824 0.9681511922049887 0.84863599676218 1.0 11.505815882024937 -5.359421674611131 2.6601059221159287 0.9550137152210871 1.098320181929712 0.5822080361505455 0.046369689056018445 0.2026172100574215 2.737701395605053 0.013138417931098434 0.03577546669875896 4.370975028785772e-06 5.359421674611131 0.1433064667086248 ALQLS(ph)NSPGASSAFLK ddPTM_A459_Selumetinib_30min_R2 2 ALQLSNSPGASSAFLK 16 0 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 ALQLS(0.93)NS(0.061)PGAS(0.007)S(0.002)AFLK;ALQLS(0.515)NS(0.06)PGAS(0.261)S(0.164)AFLK 139.0 0.00040322 135672000.0 172495.0 138809.0 161172.0 171691.0 177898.0 145071.0 155132.0 155205.0 144263.0 161453.0 True False 162908.4184521957 149455.20395871776 150802.36899080532 148306.38961650516 155548.8628117015 165053.21342657987 162345.94538822622 155656.6208544292 173119.63104500648 156791.43238472787 1.0390135224510115 0.95321027230615 0.9618023555060914 0.9458832498742502 0.9920750161273008 1.0526928092702132 1.0354261257711386 0.9927622860953644 1.104139610257614 1.0 17.258487202297026 -6.606972452332715 4.952694254470091 1.0361243246497487 0.9720466720211706 0.3889234944479467 0.03707815126523374 0.20938900502642685 8.992357230481522 0.012039817080525752 0.012057572927195727 2.471880933547324e-07 6.606972452332715 -0.06407765262857812 ALQLSNS(ph)PGASSAFLK ddPTM_A459_Selumetinib_30min_R1 1 ALQLSNSPGASSAFLK 16 0 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 ALQLS(0.079)NS(0.888)PGAS(0.026)S(0.007)AFLK 193.41 1.1589e-06 129730000.0 6083.7 7358.0 7242.5 7341.0 6202.5 5824.1 6824.1 6446.3 3248.8 5712.6 True False 6225.438373180486 6496.521939358605 6259.0082802048155 6059.032157636728 5641.484970140316 5765.514841859699 6309.352642885574 6275.32318346657 5512.976317036186 6445.8678554361295 0.9658029784042589 1.0078583807577992 0.9710109516015403 0.9399870263438361 0.8752095290601659 0.8944512936295066 0.9788212827795678 0.9735420154749636 0.8552729346424331 1.0 12.654158897158036 -5.729412146388864 3.422058296673193 0.9274754963372045 0.986866774780951 0.21532898643193477 0.04475933753548028 0.34212854163654405 8.282184802634635 0.012877879435508333 0.022625420347822025 1.8646093327002596e-06 5.729412146388864 0.059391278443746476 ALQS(ph)PALGLR ddPTM_A459_Selumetinib_30min_R2 1 ALQSPALGLR 10 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 ALQS(1)PALGLR 128.21 0.0031558000000000003 2885200.0 28736.0 28443.0 32079.0 27302.0 32199.0 28082.0 28393.0 24465.0 20926.0 26460.0 True False 27138.96815932229 30624.486641340234 30015.07206497436 23583.420501423014 28153.873757287736 31950.04059698502 29713.33075966216 24536.189099601223 25111.78472129238 25696.031048663688 1.0561540849606672 1.1917983202675515 1.168082028237403 0.9177845581195101 1.095650674766439 1.2433842618137159 1.156339307941776 0.9548629923871927 0.9772631685311693 1.0 14.649257920735172 -7.7655990846695495 24.999968472946435 0.9745472731453484 1.1193953716021796 0.3716941471610209 0.08402593244867387 123.06648293386485 739611.7781125382 0.04724070514384498 0.02397485984808473 1.7155402634422297e-08 7.7655990846695495 0.14484809845683122 ALQT(ph)SPQPPEGPGLPR ddPTM_A459_Selumetinib_30min_R1 1 ALQTSPQPPEGPGLPR 16 0 A0A2R8YGT1;F8W9A8;B7WPL9;Q6PFW1-7;Q6PFW1-4;Q6PFW1-3;Q6PFW1-2;Q6PFW1;H7C398;Q6PFW1-5 A0A2R8YGT1 PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 1 ALQT(0.94)S(0.06)PQPPEGPGLPR 128.85 0.0021511 3081200.0 2028.4 1986.7 2218.4 2281.7 2469.6 1858.9 2513.0 1731.0 1386.4 1390.9 True False 2075.657773420665 1754.0962404082268 1917.1534647989465 1883.2439278136092 2246.225116043292 1840.201153746157 2323.442386772092 1685.0882569195705 2352.6195413503333 1569.4355635133059 1.3225504899188982 1.1176605661219652 1.2215560226679498 1.1999498237428865 1.4312311816198042 1.172524184189328 1.4804318449181069 1.0736906287170955 1.499022703476789 1.0 10.61603008191078 -4.446245370206981 21.042545316398844 1.2531704396589352 4.165855320967439 0.017530931301929287 0.16395232035956622 1442.7650796286637 402061.44638034084 0.03610460954840462 2957.7164742058944 3.578941748505253e-05 4.446245370206981 2.912684881308504 ALQT(ph)SPQPPEGPGLPR ddPTM_A459_Selumetinib_30min_R2 1 ALQTSPQPPEGPGLPR 16 0 A0A2R8YGT1;F8W9A8;B7WPL9;Q6PFW1-7;Q6PFW1-4;Q6PFW1-3;Q6PFW1-2;Q6PFW1;H7C398;Q6PFW1-5 A0A2R8YGT1 PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 1 ALQT(0.724)S(0.276)PQPPEGPGLPR 177.39 2.7215e-06 7451400.0 26759.0 28152.0 37636.0 35098.0 36229.0 26410.0 29309.0 27291.0 21625.0 29271.0 True False 25271.841904764264 30311.167877052736 35214.54073497849 30317.59185257289 31677.589128630618 30047.73777388985 30671.92657468173 27370.412291731733 25950.604252984238 28425.870174808584 0.8890437390078751 1.0663233065742674 1.2388201493365758 1.0665492970357957 1.11439294325293 1.0570560404697333 1.0790145169192966 0.9628698127238964 0.9129220704026868 1.0 14.79491689322865 -7.778074697012331 5.299299421997883 0.9511593771038953 1.0802632876422347 0.28574995734543174 0.08226203364498079 0.2194740017883711 17.511354035056602 0.04576250046501883 0.022751032490080043 1.666960476980313e-08 7.778074697012331 0.12910391053833936 ALQTS(ph)PQPPEGPGLPR ddPTM_A459_Selumetinib_30min_R1 1 ALQTSPQPPEGPGLPR 16 0 A0A2R8YGT1;F8W9A8;B7WPL9;Q6PFW1-7;Q6PFW1-4;Q6PFW1-3;Q6PFW1-2;Q6PFW1;H7C398;Q6PFW1-5 A0A2R8YGT1 PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 1 ALQT(0.12)S(0.88)PQPPEGPGLPR 128.85 0.00091983 4424600.0 1939.6 2090.7 2594.6 3065.7 2723.3 2380.7 2247.2 2681.2 1261.3 1963.2 True False 1984.7889061953865 1845.9198720599397 2242.267571117628 2530.333045316293 2476.977995837666 2356.75231950265 2077.6918947689 2610.0858662349815 2140.333978292828 2215.1958431873754 0.8959880058909538 0.8332987251384075 1.012220918531203 1.1422615535768958 1.1181756247220203 1.063902465667141 0.9379269562818314 1.1782641585673126 0.9662053063503265 1.0 11.11321853626641 -5.384763856481373 4.362566014962659 1.0640739336165639 0.8659512534476659 0.5149635053230981 0.07357978349158492 0.16120477114143517 4.918903357981714 0.019086227789736766 0.04202835825175965 4.123216541574235e-06 5.384763856481373 -0.198122680168898 ALQTS(ph)PQPPEGPGLPR ddPTM_A459_Selumetinib_30min_R2 1 ALQTSPQPPEGPGLPR 16 0 A0A2R8YGT1;F8W9A8;B7WPL9;Q6PFW1-7;Q6PFW1-4;Q6PFW1-3;Q6PFW1-2;Q6PFW1;H7C398;Q6PFW1-5 A0A2R8YGT1 PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 1 ALQT(0.074)S(0.926)PQPPEGPGLPR 116.58 0.0019093 7838800.0 39675.0 29584.0 44022.0 49280.0 43614.0 36568.0 31864.0 32300.0 37906.0 35657.0 True False 37470.02233160889 31852.997672446996 41189.672447529585 42567.97898725832 38134.81940589299 41604.910068746845 33345.73913731816 32393.987652447144 45488.25918213274 34627.48976198794 1.0820889007305783 0.9198760259952016 1.189507894757801 1.2293117196727033 1.1012874357342295 1.2014994547603133 0.9629845930652238 0.9354991619406208 1.313645877734606 1.0 15.079630186108714 -10.195459546928884 15.007208284956683 1.0000034472561492 1.0984432199735272 0.05598238830993729 0.12625914319106732 0.0 0.0 0.12352553994406382 0.02995934403828404 6.375884674915439e-11 10.195459546928884 0.09843977271737803 ALRPPT(ph)SPGVFGALQNFK ddPTM_A459_Selumetinib_30min_R1 1 ALRPPTSPGVFGALQNFK 18 1 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 ALRPPT(0.884)S(0.116)PGVFGALQNFK 103.88 0.0027008 9556900.0 5278.6 7955.0 7195.0 7363.6 6080.0 6024.9 7708.8 5693.9 3770.6 5497.3 True False 5401.581109632378 7023.6249018208355 6217.958519305993 6077.685491891266 5530.065073511181 5964.294976171509 7127.319009609514 5542.879275606208 6398.43280627205 6202.932003236535 0.8708109498562886 1.1323072537561405 1.0024224860213875 0.9798084984197927 0.8915243743806528 0.9615283503123183 1.149024204342504 0.8935902042314944 1.0315174828506113 1.0 12.598734594783567 ALRPPTS(ph)PGVFGALQNFK ddPTM_A459_Selumetinib_30min_R1 1 ALRPPTSPGVFGALQNFK 18 1 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 ALRPPT(0.368)S(0.632)PGVFGALQNFK 79.029 0.0068409 11776000.0 1812.0 3216.6 1844.7 2267.7 1971.8 2556.0 2756.9 1767.2 1230.7 2419.0 True False 1854.2160744617643 2839.9989766432304 1594.1998722117817 1871.6887650010617 1793.4510381495654 2530.2889606623166 2548.9448134070767 1720.3281153253986 2088.4080132284016 2729.5022130553493 0.6793238948819874 1.040482386516988 0.5840624948339085 0.6857253150587965 0.6570615805224106 0.9270148045895749 0.9338496965546841 0.630271742260175 0.7651241326126935 1.0 11.414422151470793 -6.756163254065979 24.99957105804334 0.8333064081810786 0.7361243033576843 0.13816416373180251 0.14843274585137514 358.1162201775141 1696840.7349946147 0.05137285102571788 0.049922198306569236 1.7532213308747001e-07 6.756163254065979 -0.09718210482339429 ALS(ph)AIADLLTNEHER ddPTM_A459_Selumetinib_30min_R1 1 ALSAIADLLTNEHER 15 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28 O60716-5 CTNND1 Catenin delta-1 1 ALS(1)AIADLLTNEHER 112.74 0.0019402 1038000.0 739.98 514.9 683.77 716.9 751.13 348.22 494.46 591.43 577.61 395.49 True False 757.2200942495678 454.61526862948404 590.9177896797581 591.706872879685 683.1904241227725 344.71722295846286 457.1624841079704 575.743355164611 980.1619830347427 446.254993898826 1.6968327628872275 1.0187342995483732 1.324170704549538 1.3259389384308728 1.5309418011301046 0.7724669251244647 1.0244422815615981 1.2901667500333729 2.1964168388823966 1.0 8.801724503751775 -11.64315113534694 2.6734657342577597 0.33221445408430783 1.3184469275676844 0.06602775496342494 0.3787360954667453 105460442.45548072 84423760.48958403 418041537.63965845 0.09378445097286454 2.2743058300703456e-12 11.64315113534694 0.9862324734833766 ALS(ph)ASHTDLAH ddPTM_A459_Selumetinib_30min_R1 1 ALSASHTDLAH 11 0 Q07866-6;Q07866-4;Q07866-7;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 ALS(0.834)AS(0.057)HT(0.109)DLAH 157.75 0.00056426 17821000.0 2913.7 3340.7 3467.8 3736.0 4023.4 2987.2 3292.0 2900.5 1551.3 2308.6 True False 2981.5835409267347 2949.5692909507034 2996.891807261896 3083.5777334056384 3659.484180388962 2957.1514801605913 3043.6817895955955 2823.56931784819 2632.442797530851 2604.9312976682836 1.14459200655142 1.1323021430894975 1.1504686553324697 1.183746280051915 1.4048294416304283 1.1352128491095277 1.1684307345533622 1.0839323556731086 1.010561314951835 1.0 11.347029608098577 -7.923963771884552 1.700627816898096 0.9993778003584608 1.1953403609737128 0.5021916217499722 0.0748513016391437 0.34419054754022277 1.8234545638777773 0.06744895182258095 0.023542306751618777 1.1913413835775158e-08 7.923963771884552 0.19596256061525197 ALS(ph)DREEEEEDDEEEEEEVEAAAQR ddPTM_A459_Selumetinib_30min_R2 1 ALSDREEEEEDDEEEEEEVEAAAQR 25 1 Q8N3E9 Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 1 ALS(1)DREEEEEDDEEEEEEVEAAAQR 117.6 4.2741e-08 9247000.0 20132.0 13176.0 18822.0 19540.0 12551.0 12410.0 24026.0 18645.0 15056.0 13476.0 True False 19013.14403478135 14186.556832482478 17611.0130118441 16878.618291619885 10974.23117263637 14119.36485323638 25143.256606615832 18699.253863154092 18067.620699788687 13086.912865147086 1.4528364504830575 1.0840262312943147 1.3456965132506955 1.289732610398196 0.838565312210706 1.0788919433275137 1.9212519305127385 1.4288514071912046 1.3805869180886934 1.0 13.67583719269089 ALS(ph)GHSAADRNER ddPTM_A459_Selumetinib_30min_R1 1 ALSGHSAADRNER 13 1 A0A0U1RQE4 A0A0U1RQE4 1 ALS(0.997)GHS(0.003)AADRNER 148.62 0.0025709 892480.0 472.5 310.01 473.16 624.0 654.69 420.91 637.58 358.42 166.84 420.43 True False 483.50833067504647 273.71388508026087 408.9074708818382 515.0301139307065 595.4734050949073 416.6760275557022 589.486827281397 348.9135372877603 283.11529448852417 474.3962858349986 1.0192076647986599 0.5769730776843861 0.8619533564899404 1.0856537652359297 1.255223581792588 0.8783290257475324 1.2426042211604256 0.7354896058547918 0.596790706297805 1.0 8.889948904489154 -12.004214610030541 2.3006560264095954 1.982451720399662 0.9233206481962697 0.01121298923269154 0.22700155513234185 25440191.09325509 6807093.712950291 125822487.23023744 0.060827895481510914 9.903424384587894e-13 12.004214610030541 -1.0591310722033924 ALS(ph)IESLSPTDSSNGVNWR ddPTM_A459_Selumetinib_30min_R1 1 ALSIESLSPTDSSNGVNWR 19 0 H3BRG5;Q9Y3M8-5;Q9Y3M8-3;Q9Y3M8-4;Q9Y3M8-2;Q9Y3M8 H3BRG5 STARD13 StAR-related lipid transfer protein 13 1 ALS(1)IESLSPTDSSNGVNWR 346.19 2.0833999999999994e-174 19434000.0 1918.0 1941.4 2132.9 2085.5 1669.7 1682.8 1986.7 1563.9 1015.1 1665.2 True False 1962.6856682216696 1714.0999854676252 1843.2638951810638 1721.3065746834739 1518.6759298094778 1665.8725598601493 1836.841619498653 1522.4202917368677 1722.5505600293745 1878.9446404215669 1.0445681187186624 0.9122674232078724 0.98101022006029 0.9161028684151521 0.8082600717117148 0.8866001286160236 0.9775921972275524 0.8102528722694523 0.9167649344064213 1.0 10.875706845743725 -1.5228814556110557 0.8025424162117623 0.896974253559523 36.43614636460304 0.27515298075082073 0.06279592218214818 637.5002166135399 2.1927819259319516 0.02207563281694155 41200.43610044483 0.029999812777570946 1.5228814556110557 35.53917211104352 ALS(ph)IESLSPTDSSNGVNWR ddPTM_A459_Selumetinib_30min_R2 2 ALSIESLSPTDSSNGVNWR 19 0 H3BRG5;Q9Y3M8-5;Q9Y3M8-3;Q9Y3M8-4;Q9Y3M8-2;Q9Y3M8 H3BRG5 STARD13 StAR-related lipid transfer protein 13 1 ALS(0.994)IES(0.006)LSPTDSSNGVNWR;ALS(0.986)IES(0.004)LS(0.003)PT(0.005)DS(0.001)S(0.001)NGVNWR 272.32 7.5686e-59 12343600.0 16546.9 17139.300000000003 19409.9 22838.0 19692.5 19310.5 17545.800000000003 18212.9 15956.1 21092.1 True False 15627.28954048895 18453.829198464406 18161.088165901238 19727.425002252552 17218.552096816315 21970.346091734173 18361.714466343135 18265.896523692085 19147.765850684 20483.116269142825 0.7629351576757377 0.9009287920834841 0.886636971018924 0.9631066261129075 0.8406217037763695 1.0726075955948076 0.8964316867157799 0.891753788031223 0.9348072626785561 1.0 14.322147600943374 -3.8598322341003737 0.9942793370882808 0.9374149233587731 1.2999900306711774e-13 0.41986977972867 0.0615559280753831 10.048926355221717 2.0311710240084184 0.018999336198259043 15.552639216764728 0.00013809176035072297 3.8598322341003737 -0.9374149233586431 ALS(ph)ISPLSDASLDLQR ddPTM_A459_Selumetinib_30min_R1 1 ALSISPLSDASLDLQR 16 0 P10070 P10070 GLI2 Zinc finger protein GLI2 1 ALS(0.5)IS(0.5)PLSDASLDLQR 188.0 8.9058e-07 3120900.0 445.35 332.5 525.07 570.97 355.5 370.77 378.16 404.92 182.66 236.16 True False 455.7257884997498 293.57074542494377 453.76837800305776 471.2608079343199 323.3450877686229 367.04039043222497 349.6350867416373 394.180206234473 309.96067904143985 266.47343639320053 1.7102109488590598 1.1016885937994931 1.7028653367665894 1.7685095156687252 1.213423342098175 1.377399546462225 1.3120823278824905 1.4792476562385455 1.1631954135348441 1.0 8.057847913776541 -6.283949541534129 24.706574125712987 1.2902387105961184 1.5467412609302513 0.335876930656263 0.21176114073266866 972.9435538474797 1067874.641199641 0.06544165275741351 0.07425586278795235 5.200564157320964e-07 6.283949541534129 0.25650255033413294 ALS(ph)PAELR ddPTM_A459_Selumetinib_30min_R2 3 ALSPAELR 8 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 ALS(1)PAELR;ALS(1)PAELR;ALS(1)PAELR 114.97 0.010073 17975100.0 122251.0 90962.0 112872.0 118144.0 108844.0 68158.0 129795.0 111883.0 88102.0 90704.0 True False 115456.7788295278 97938.49291107092 105609.93840574162 102052.58339023252 95170.04364229401 77546.14582327844 135830.72468391334 112208.56100677226 105724.86177555704 88085.13984270571 1.3107407110404754 1.1118616952412224 1.198952951591268 1.1585675355964533 1.080432452196135 0.8803544611696498 1.5420390423000665 1.2738648222293103 1.2002576366950284 1.0 16.42661103338856 -7.256920911157147 24.998879942349532 1.2768624364578447 1.1260247444116234 0.1315801693773997 0.15999357803915598 715.2914881080575 3957435.339592372 0.06194163199435924 0.046285445787013005 5.534508883109917e-08 7.256920911157147 -0.15083769204622133 ALS(ph)PEGALR ddPTM_A459_Selumetinib_30min_R2 1 ALSPEGALR 9 0 K7EPS7;I3L2Z9;I3L100;I3L2W2;Q96JN8-2;Q96JN8 K7EPS7 NEURL4 Neuralized-like protein 4 1 ALS(1)PEGALR 90.827 0.028028 7464100.0 35486.0 30742.0 34667.0 42878.0 53212.0 43743.0 38326.0 41213.0 34178.0 42533.0 True False 33513.83018171321 33099.81254889012 32436.562962575685 37037.94243132432 46527.03283868427 49768.201190581705 40108.23494152828 41332.92300682055 41014.555013109595 41304.961775994416 0.8113754072323279 0.8013519714265186 0.7852945885408649 0.8966947514003027 1.1264272096657602 1.2048964349727578 0.9710270441368222 1.0006769460525777 0.9929692039310009 1.0 15.334027475955798 -6.046269420838348 4.090325643336387 1.052368214475434 0.8027725282431208 0.7400982397017082 0.06723151936543023 0.12136550524082754 4.2900505910741105 0.022314748306198517 0.030750176472764817 8.989397382979947e-07 6.046269420838348 -0.2495956862323132 ALS(ph)PEGALRR ddPTM_A459_Selumetinib_30min_R2 1 ALSPEGALRR 10 1 K7EPS7;I3L2Z9;I3L100;I3L2W2;Q96JN8-2;Q96JN8 K7EPS7 NEURL4 Neuralized-like protein 4 1 ALS(1)PEGALRR 69.815 0.038943 7372900.0 23909.0 24373.0 27528.0 35623.0 32152.0 17788.0 22255.0 24024.0 17105.0 34824.0 True False 22580.233495310316 26242.330728452907 25756.878450220218 30771.085946897405 28112.778317473072 20238.13553661313 23289.901597445907 24093.905862612686 20526.477953632133 33818.54063638186 0.6676879921606843 0.775974664625874 0.7616200452633093 0.9098880486224762 0.8312830118763153 0.5984331421693879 0.6886725789814454 0.7124466464023747 0.6069593059716427 1.0 15.045526784357033 -6.730867923509562 24.999487013047954 0.701290732868544 0.7937135654672717 0.0627964303591142 0.11879567734948633 431.80305934893414 353101.2883247892 0.037757719863834756 0.037753558020905346 1.858369531594725e-07 6.730867923509562 0.09242283259872763 ALS(ph)PELGTK ddPTM_A459_Selumetinib_30min_R2 2 ALSPELGTK 9 0 Q15583 Q15583 TGIF1 Homeobox protein TGIF1 1 ALS(0.995)PELGT(0.005)K;ALS(0.989)PELGT(0.011)K 94.363 0.023342 5901800.0 66337.0 59757.0 67956.0 71632.0 67713.0 51707.0 51825.0 52692.0 46590.0 63590.0 True False 62650.255108051395 64340.169750960515 63583.784944898485 61875.59802790769 59206.2875780995 58829.16990058774 54234.96518928933 52845.32499636982 55909.30183336576 61753.99147333802 1.014513452706945 1.0418787225881434 1.0296303676556757 1.0019692096278856 0.9587443040610828 0.9526375299317607 0.8782422624893002 0.8557394224336985 0.9053552733915884 1.0 15.914244767950194 -6.52939732145391 1.3049091268988138 0.9003989886848137 1.029945156876853 0.6314248114725531 0.03758763697519786 0.24886492215284672 0.8799618290259132 0.016061235697362352 0.017889070362305748 2.9553075176889625e-07 6.52939732145391 0.12954616819203923 ALS(ph)PGLEESGLGLLAR ddPTM_A459_Selumetinib_30min_R1 4 ALSPGLEESGLGLLAR 16 0 H9KVB4;O15417;O15417-2 H9KVB4 TNRC18 Trinucleotide repeat-containing gene 18 protein 1 ALS(1)PGLEESGLGLLAR;ALS(1)PGLEESGLGLLAR;ALS(1)PGLEESGLGLLAR;ALS(1)PGLEESGLGLLAR 245.39 2.7669999999999997e-22 64091000.0 4275.7699999999995 5114.18 4866.67 5512.08 5097.3 4613.6900000000005 4946.86 4837.56 2428.8199999999997 3815.6 True False 4375.387121799881 4515.409428082219 4205.802944704783 4549.498702556359 4636.2501150014095 4567.280467495353 4573.714367460165 4709.2521941905525 4121.530146005856 4305.36942709136 1.0162628772964144 1.0487855930943326 0.9768738817718965 1.0567034442918708 1.0768530305037232 1.0608335811454248 1.0623279709007676 1.0938090851293216 0.9572999984789452 1.0 12.07192131967467 -4.750596839260828 23.814570342116564 1.0414956476015478 1.0162627794628045 0.011571450360249202 0.04250408353071444 1175.7290238672 2582050.636547191 0.010438105814928532 0.13975080135631146 1.7758372468145318e-05 4.750596839260828 -0.02523286813874326 ALS(ph)PGLEESGLGLLAR ddPTM_A459_Selumetinib_30min_R2 5 ALSPGLEESGLGLLAR 16 0 H9KVB4;O15417;O15417-2 H9KVB4 TNRC18 Trinucleotide repeat-containing gene 18 protein 1 ALS(0.992)PGLEES(0.008)GLGLLAR;ALS(1)PGLEESGLGLLAR;ALS(1)PGLEESGLGLLAR;ALS(1)PGLEESGLGLLAR;ALS(1)PGLEESGLGLLAR 211.7 3.5469e-08 17741460.0 17526.9 16393.2 20021.1 21588.4 25111.100000000002 16769.1 17971.8 19560.1 16027.699999999999 21334.9 True False 16552.825063739776 17650.505727554013 18732.964223325467 18648.022677932782 21956.4191219177 19078.891310266416 18807.524310446108 19617.016652651135 19233.687851355156 20718.906002272674 0.7989237009871121 0.8519033642808126 0.9041483281632068 0.9000486162680242 1.059728690284578 0.9208445324368785 0.9077469779718628 0.9468172040791791 0.9283158024485172 1.0 14.338660207537044 -5.235681253408306 1.319315144497974 0.9521136897612298 0.790331570862577 0.5810007031821292 0.04427045079121683 0.5145522997999735 1.330461653410664 0.014117002852451719 0.08976125201499006 5.8119082088441e-06 5.235681253408306 -0.1617821188986528 ALS(ph)PLPTR ddPTM_A459_Selumetinib_30min_R1 1 ALSPLPTR 8 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 ALS(0.994)PLPT(0.006)R 86.882 0.03325 20085000.0 5007.0 6564.0 6389.2 6697.5 5979.6 5622.9 5928.3 5197.5 3015.8 4944.3 True False 5123.653358073982 5795.483828479191 5521.581733363428 5527.9073526456805 5438.746235784129 5566.3387311847155 5481.123558098287 5059.645416140653 5117.592334682876 5578.949066560386 0.9183904167156863 1.0388128228695779 0.9897171792549941 0.9908510163283898 0.9748693115668293 0.9977396575546359 0.9824652443865359 0.9069172985406189 0.9173040071932486 1.0 12.44577766491415 -7.671031683358193 7.584003971708568 0.9343010658952527 0.9876357533719907 0.222510446239228 0.0361390310341165 0.26729796080363244 19.218049624889275 0.01618494050787634 0.009270494374833963 2.1328893054570373e-08 7.671031683358193 0.053334687476737974 ALS(ph)PLPTR ddPTM_A459_Selumetinib_30min_R2 2 ALSPLPTR 8 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 ALS(0.988)PLPT(0.012)R;ALS(0.993)PLPT(0.007)R 92.051 0.026006 27145800.0 123766.0 108790.0 108144.0 126193.0 136489.0 81506.0 130056.0 128039.0 109621.0 96605.0 True False 116887.58119455336 117133.84318501595 101186.13277828456 109005.29570493306 119342.03159285834 92732.71166219862 136103.86170107484 128411.57229200237 131548.26306665345 93815.76264006633 1.2459268880327115 1.248551841276522 1.0785621726116048 1.1619081126392685 1.272089340154129 0.9884555542971714 1.4507568650616964 1.3687632939111347 1.4021978755462627 1.0 16.51754271990351 -7.276402373093672 24.996206942716146 1.3361597718006346 1.1703451351935505 0.17980594113106063 0.13975687071575726 1159.8668912655035 1937590.7284078225 0.05531663280951509 0.03746491758474225 5.291729388791548e-08 7.276402373093672 -0.16581463660708406 ALS(ph)PVIPLIPR ddPTM_A459_Selumetinib_30min_R1 2 ALSPVIPLIPR 11 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ALS(1)PVIPLIPR;ALS(1)PVIPLIPR 181.4 4.234e-05 706600000.0 5001.200000000001 5250.0 5909.4 6682.7 5522.5 4607.4 5039.8 5073.200000000001 2644.3 4320.7 True False 5117.718229358819 4635.3275593412145 5106.935938010677 5515.691894815275 5022.990850076565 4561.053739184489 4659.643828433745 4938.64225592396 4487.18396796934 4875.303932181995 1.0497229096993608 0.9507771461679156 1.047511295511173 1.1313534441219273 1.03029286377813 0.9355424405598319 0.9557647878474461 1.01299166669874 0.9203906116189667 1.0 12.251276445633817 -6.660387551836264 6.483149230940983 0.9654395348357204 1.0432387429648264 0.39475166125173455 0.04784651482222125 0.24683691952897624 13.68343842026013 0.016792781226646215 0.016739390141740227 2.1858101995711801e-07 6.660387551836264 0.07779920812910601 ALS(ph)PVIPLIPR ddPTM_A459_Selumetinib_30min_R2 2 ALSPVIPLIPR 11 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ALS(1)PVIPLIPR;ALS(1)PVIPLIPR 168.85 0.00045552 231190000.0 629000.0 567840.0 652850.0 665130.0 727230.0 574420.0 568900.0 659770.0 503900.0 590720.0 True False 594042.6980865026 611391.502106621 610846.3417693349 574538.1465867505 635868.865881312 653541.1409344111 595354.9772539634 661689.8214691966 604694.0801423703 573664.3787251187 1.0355230690925443 1.0657651490673783 1.0648148367288333 1.0015231342471946 1.108433588458871 1.1392395365157695 1.0378106072701405 1.1534441495909176 1.0540903402198518 1.0 19.129847412102272 -6.284123254548968 24.77692995720722 1.0904774484550013 1.0452470305915798 0.1362361708764297 0.046646741824104235 1200.1651466767105 1310901.637110532 0.013697299980157104 0.015545357075979956 5.198484404839211e-07 6.284123254548968 -0.045230417863421524 ALS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 ALSPVR 6 0 Q02535 Q02535 ID3 DNA-binding protein inhibitor ID-3 1 ALS(1)PVR 101.6 0.030237 36577000.0 7066.5 7745.0 7302.9 7790.6 7863.6 6685.8 7778.7 6560.5 4358.6 5698.3 True False 7231.135700984577 6838.211799447183 6311.206291958272 6430.117957673975 7152.3387684313375 6618.546922220702 7191.946396332701 6386.49422849269 7396.225860451214 6429.73231114233 1.1246402417801227 1.0635297814182687 0.98156594809108 1.0000599786294333 1.112385154205685 1.0293658587856243 1.1185452283712496 0.9932752903919948 1.1503162966262235 1.0 12.650542959785055 -6.254919384697427 24.980452262661313 1.0676424929819395 1.0396059742671229 0.0390188816183209 0.059778547559701606 1881.604162032092 7209112.2743438585 0.017416711615367307 0.021940852079141367 5.560074557942866e-07 6.254919384697427 -0.028036518714816605 ALS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 3 ALSPVR 6 0 Q02535 Q02535 ID3 DNA-binding protein inhibitor ID-3 1 ALS(1)PVR;ALS(1)PVR;ALS(1)PVR 104.37 0.026396 88544000.0 351370.0 349527.0 370470.0 451050.0 433020.0 321311.0 326835.0 310456.0 289660.0 356190.0 True False 331842.2620455553 376334.5969935565 346634.36353723775 389616.2118953502 378620.1563520839 365568.67367914907 342033.47511126613 311359.37556124217 347600.09377661964 345905.86920723825 0.9593426755263953 1.0879682320975244 1.0021060479016128 1.126364848299016 1.0945756925715706 1.0568443794173683 0.9888050639185538 0.9001274718894733 1.0048979353061116 1.0 18.400019967489484 -7.345629285497832 3.964716101275993 0.961591240810205 1.058935270777133 0.36655230773240266 0.0520554352931583 0.2292069111574358 6.724507821433616 0.02262917535063838 0.014880829819957017 4.512016867280817e-08 7.345629285497832 0.09734402996692793 ALS(ph)PVTSR ddPTM_A459_Selumetinib_30min_R1 4 ALSPVTSR 8 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4;A0A0A0MR72;A0A0A0MR80 Q96L91-3 EP400 E1A-binding protein p400 1 ALS(0.994)PVT(0.006)SR;ALS(0.995)PVT(0.005)SR;ALS(0.995)PVT(0.005)SR;ALS(0.986)PVT(0.014)SR 101.46 0.017015 212361900.0 16563.6 21726.4 23426.7 24741.6 21939.399999999998 19231.800000000003 20369.7 17685.5 10200.300000000001 14653.5 True False 16949.49965284486 19182.662987670672 20245.482813651957 20420.94401735251 19954.985143715672 19038.345553077288 18833.19712926045 17216.42308939982 17309.1640995642 16534.419462177175 1.0251040075290936 1.1601654978907128 1.224444732393775 1.2350566080693575 1.206875462991798 1.1514371941892423 1.139029838473723 1.0412475097043923 1.0468564765251824 1.0 14.013184771692252 -7.718054581354813 1.7577484247493484 1.0193287297818052 1.1754295183005803 0.5486552540727848 0.05601707772121764 0.29748267009934615 1.7767571943237943 0.04365388300050753 0.018091604102426648 1.914015359872607e-08 7.718054581354813 0.15610078851877507 ALS(ph)PVTSR ddPTM_A459_Selumetinib_30min_R2 3 ALSPVTSR 8 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4;A0A0A0MR72;A0A0A0MR80 Q96L91-3 EP400 E1A-binding protein p400 1 ALS(0.876)PVT(0.124)SR;ALS(0.997)PVT(0.003)SR;ALS(0.985)PVT(0.015)SR 101.65 0.016863999999999997 139484000.0 467160.0 430640.0 531450.0 545820.0 628270.0 420353.0 432755.0 441359.0 374616.0 523440.0 True False 441197.11738965043 463668.7032741533 497257.08559900936 471478.3744079826 549341.1057949361 478252.81016538834 452878.9649877644 442643.28161908407 449549.667645593 508326.9271395507 0.8679396935990543 0.9121466491718283 0.9782229881017058 0.9275101302641557 1.0806846469577753 0.9408370570817585 0.890920667012857 0.8707846426903242 0.8843711470790891 1.0 18.9553971298184 -10.019793066995232 10.826773638483331 1.0000013653656998 0.931216460210472 0.1110934176768168 0.06041067045485192 0.0 0.0 0.06332532954853969 0.015358648382686841 9.554477301276169e-11 10.019793066995232 -0.06878490515522784 ALS(ph)SAGPIPIRPPIVPVK ddPTM_A459_Selumetinib_30min_R1 2 ALSSAGPIPIRPPIVPVK 18 1 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 ALS(0.971)S(0.029)AGPIPIRPPIVPVK;ALS(0.958)S(0.042)AGPIPIRPPIVPVK 120.74 0.00052065 68515000.0 5319.4 5480.7 5610.7 6295.1 5870.1 4382.0 4893.6 4479.6 2797.8 3280.4 True False 5443.3316702493985 4839.017096091693 4848.797757369023 5195.778958662165 5339.150491450329 4337.92105853766 4524.471812140037 4360.786456208498 4747.662256772912 3701.4712938018884 1.4705859476377015 1.3073226055257066 1.309964976761628 1.403706403819069 1.4424400644118824 1.1719450764893158 1.222344158042307 1.1781224572808744 1.282641922611387 1.0 11.853883124688855 -6.770611297080466 24.996905569886234 1.1853516765976664 1.3790585559550426 0.627419359750871 0.08266986649886253 141.18655219745455 384783.87556052394 0.028056776379906133 0.025086119503340665 1.6958549481271828e-07 6.770611297080466 0.19370687935737618 ALS(ph)SAGPIPIRPPIVPVK ddPTM_A459_Selumetinib_30min_R2 2 ALSSAGPIPIRPPIVPVK 18 1 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 ALS(0.705)S(0.295)AGPIPIRPPIVPVK;ALS(0.5)S(0.5)AGPIPIRPPIVPVK 93.115 0.0026044 28316000.0 32244.0 31930.0 36538.0 36913.0 38246.0 28109.0 31739.0 31869.0 27252.0 37172.0 True False 30452.007562958937 34378.92832886804 34187.184859566485 31885.385721523253 33441.19555642183 31980.75960190345 33214.92638963537 31961.733513803036 32703.16148450064 36098.747775545235 0.8435751775187164 0.9523579195220098 0.9470462818304817 0.8832823210317482 0.9263810413688716 0.8859243484220947 0.9201129799891984 0.8853972916881959 0.9059361750674104 1.0 15.139661172081711 -12.046171725222537 2.0630545915424654 2.1126836286049064 0.9073689013791248 0.4514898517589796 0.031171550295842523 1700922.3413349334 127948.30871497 8842510.250699487 0.007490657338719027 8.99141979757767e-13 12.046171725222537 -1.2053147272257816 ALS(ph)SDSILSPAPDAR ddPTM_A459_Selumetinib_30min_R1 3 ALSSDSILSPAPDAR 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 ALS(0.551)S(0.16)DS(0.289)ILSPAPDAR;ALS(0.617)S(0.203)DS(0.18)ILSPAPDAR;ALS(0.821)S(0.045)DS(0.133)ILS(0.001)PAPDAR 217.39 3.2184e-09 1073116000.0 7213.7 8110.1 7224.3 8345.6 7637.7 6506.3 7465.4 7021.1 3747.98 6647.8 True False 7381.765174583245 7160.565721716796 6243.279740239375 6888.19762631427 6946.87138354546 6440.852529247742 6902.278867571978 6834.877620253037 6360.048318371481 7501.109885055541 0.9840897264136783 0.9546008299362191 0.8323141289634831 0.9182904572612146 0.9261124673544258 0.8586532697087734 0.9201676782956327 0.9111821750365452 0.8478809690606725 1.0 12.872888361230451 -5.01772355758884 22.657794319792526 0.8988374693646969 0.9767176157036701 0.26907035244163824 0.045447342157947525 218.00706675419406 278709.09993585135 0.010705480569552787 0.029908009029024588 9.600115152895784e-06 5.01772355758884 0.07788014633897322 ALS(ph)SDSILSPAPDAR ddPTM_A459_Selumetinib_30min_R2 7 ALSSDSILSPAPDAR 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 ALS(0.988)S(0.012)DS(0.001)ILSPAPDAR;ALS(0.394)S(0.394)DS(0.211)ILSPAPDAR;ALS(0.532)S(0.4)DS(0.068)ILSPAPDAR;ALS(0.785)S(0.08)DS(0.135)ILSPAPDAR;ALS(0.393)S(0.393)DS(0.215)ILSPAPDAR;ALS(0.93)S(0.05)DS(0.02)ILSPAPDAR;ALS(0.936)S(0.06)DS(0.004)ILSPAPDAR 238.67 5.316099999999999e-20 946703600.0 265190.0 226463.6 253855.7 266836.1 245417.1 196463.0 232390.5 210394.6 210891.1 234868.2 True False 250451.80143968159 243832.6299247556 237522.90063918778 230492.5628620531 214585.6098412888 223523.9949364527 243197.11872303986 211006.81345329873 253075.2127896656 228086.94480513016 1.09805408483006 1.069033697360794 1.0413699952977116 1.0105469344550966 0.9408061913610336 0.979994690741393 1.0662474300351532 0.9251156993381444 1.1095558888996675 1.0 17.79922434676019 -5.403244043957953 1.8520686014234942 1.0004005368399516 1.09129262066716 0.27873521426904524 0.05117610568790548 0.47217103630189294 3.0145753314901795 0.01434687257276168 0.04724921334828938 3.951445133309222e-06 5.403244043957953 0.09089208382720848 ALS(ph)TTSSSTTNGNR ddPTM_A459_Selumetinib_30min_R1 1 ALSTTSSSTTNGNR 14 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 ALS(0.495)T(0.495)T(0.011)SSSTTNGNR 153.0 0.00010283 0.0 1188.0 1391.6 1444.0 1566.1 1420.0 1162.5 1363.5 1061.8 719.43 1185.3 True False 1215.6780885544026 1228.670825062711 1247.9127313242325 1292.610034337947 1291.5612507213625 1150.8063054655483 1260.6500972398526 1033.6376147875217 1220.8201649117657 1337.4448007997137 0.9089557100431347 0.918670306488939 0.933057372220561 0.9664772957845003 0.9656931261380541 0.8604514405210844 0.942581029501971 0.7728450655828688 0.912800411786555 1.0 10.385263634302333 -6.762165336732305 24.999995885952508 0.8863412461448504 0.9387092447385114 0.09597697004039518 0.0575768652414467 36.259789813450205 1248660.5861627501 0.019050707837835443 0.01780302038229985 1.729157940187561e-07 6.762165336732305 0.052367998593660925 ALS(ph)TTSSSTTNGNR ddPTM_A459_Selumetinib_30min_R2 1 ALSTTSSSTTNGNR 14 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 ALS(0.917)T(0.032)T(0.032)S(0.006)S(0.006)S(0.006)T(0.001)TNGNR 99.834 0.0094146 2348500.0 9357.0 8660.0 11443.0 10881.0 12362.0 9033.2 8735.7 8914.7 8654.1 9717.0 True False 8836.97539903879 9324.194153711165 10706.769838196382 9398.989029228038 10808.9750423178 10277.441304774775 9141.927359461162 8940.640301091975 10385.161815757267 9436.444962202 0.9364729444653781 0.9881045447792618 1.134619009709982 0.9960307156854098 1.145449911021949 1.089122158391366 0.9687893476917909 0.9474585330496826 1.1005375284183168 1.0 13.204027733085475 -10.526824203666571 14.758469958665577 0.9999999998877231 1.034980244116731 0.018562486950438273 0.07404046531259718 0.0 0.0 0.07360005923829824 0.017850636237074193 2.97286916408329e-11 10.526824203666571 0.03498024422900792 ALS(ph)YASLDKEDLLSPINQNTLQR ddPTM_A459_Selumetinib_30min_R1 1 ALSYASLDKEDLLSPINQNTLQR 23 1 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 ALS(0.938)Y(0.045)AS(0.017)LDKEDLLSPINQNTLQR 88.829 0.00011172 13205000.0 983.86 1121.6 1149.6 1202.6 1197.1 1070.7 1146.2 935.81 687.88 911.61 True False 1006.7820237416954 990.2825505823056 993.4906343007883 992.5884855978644 1088.8225163651712 1059.9297301178167 1059.7412111890865 910.9892788607184 1167.282119232594 1028.6240233333554 0.9787658084040476 0.9627254741467144 0.9658442849519362 0.9649672407818025 1.0585233201502886 1.0304345475842691 1.0302512746638883 0.8856387350438986 1.1347995893095162 1.0 10.006500037747784 -6.22653477727047 23.817423865670914 1.0182633527451042 0.9675341306782607 0.17578552587914043 0.05794390960848613 671.1742546677784 457980.23331267 0.01650495874820985 0.021306944885502752 5.935608153481123e-07 6.22653477727047 -0.05072922206684349 ALSAS(ph)HTDLAH ddPTM_A459_Selumetinib_30min_R1 3 ALSASHTDLAH 11 0 Q07866-6;Q07866-4;Q07866-7;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 ALS(0.01)AS(0.93)HT(0.061)DLAH;ALSAS(0.952)HT(0.048)DLAH;ALSAS(0.969)HT(0.031)DLAH 124.6 0.0023325 260100000.0 20826.6 24482.9 23481.699999999997 25397.300000000003 27591.5 21166.2 24549.9 20736.8 9449.099999999999 15063.199999999999 True False 21311.81925849082 21616.43068620859 20293.014115745304 20962.138321365925 25095.853696674985 20953.287245371954 22698.081277762118 20186.79270138057 16034.43256504144 16996.708447993118 1.2538792039471154 1.2718009932541348 1.193937883787222 1.2333057536114307 1.4765125714466303 1.2327850012539343 1.3354398204343023 1.187688355257051 0.9433845743782644 1.0 14.05296776323358 -8.118986858013729 3.5110857327495273 0.9723161470905657 1.2840657111316245 0.7286543910245993 0.07538396217693706 0.12984671673481624 2.7947103367703505 0.06040188288940536 0.02026789904923871 7.603492851732946e-09 8.118986858013729 0.3117495640410588 ALSAS(ph)HTDLAH ddPTM_A459_Selumetinib_30min_R2 6 ALSASHTDLAH 11 0 Q07866-6;Q07866-4;Q07866-7;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 ALS(0.115)AS(0.769)HT(0.115)DLAH;ALS(0.012)AS(0.975)HT(0.013)DLAH;ALSAS(0.961)HT(0.039)DLAH;ALS(0.001)AS(0.967)HT(0.032)DLAH;ALS(0.037)AS(0.926)HT(0.037)DLAH;ALS(0.036)AS(0.936)HT(0.028)DLAH 140.63 0.00070814 511123000.0 563169.0 503932.0 675703.0 729002.0 775424.0 570653.0 497695.0 512218.0 501181.0 634014.0 True False 531870.3215241296 542581.9640032289 632229.0046298018 629710.6700014056 678008.3047414846 649255.2708778322 520838.8036639327 513708.4695777447 601431.2041671621 615708.3684537959 0.8638348100737928 0.8812320764224686 1.0268319175480651 1.0227417755954384 1.1011841636067738 1.0544850519220346 0.845918019551845 0.8343373192535949 0.9768118073131156 1.0 19.23188765163809 -10.21010560691656 10.960615884478683 1.000010226320769 0.9584959161106354 0.020052302709281045 0.09040255946733068 0.0 0.0 0.0983281136231539 0.023848070496235205 6.164450833543642e-11 10.21010560691656 -0.04151431021013363 ALSGGGSVAS(ph)PPPSPAMPK ddPTM_A459_Selumetinib_30min_R1 2 ALSGGGSVASPPPSPAMPK 19 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 ALSGGGS(0.001)VAS(0.999)PPPSPAMPK;ALSGGGS(0.028)VAS(0.972)PPPSPAMPK 208.59 1.976e-16 28756000.0 6341.599999999999 8193.7 8916.9 9723.5 7894.8 7519.9 7945.700000000001 8321.2 4742.7 7298.4 True False 6489.346941394442 7234.377794852217 7706.033957025659 8025.4732577006835 7180.716733940148 7444.256633522907 7346.349451880234 8100.494744933068 8048.015506897171 8235.220732436195 0.7879991505066462 0.8784679888855994 0.9357410332274131 0.9745304368212772 0.8719519448528373 0.9039535035414527 0.8920646683998462 0.9836402700206347 0.9772677343302194 1.0 13.00759160435546 -4.850829328517188 2.111575435375168 0.9373870393195916 0.7596724281936548 0.5803257890380111 0.04068588978404856 0.4505158184952899 2.5889007266970454 0.011478198299533119 0.14684303098251922 1.4098427374808912e-05 4.850829328517188 -0.17771461112593678 ALSGGGSVAS(ph)PPPSPAMPK ddPTM_A459_Selumetinib_30min_R2 4 ALSGGGSVASPPPSPAMPK 19 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 ALSGGGS(0.022)VAS(0.977)PPPS(0.001)PAMPK;ALSGGGS(0.003)VAS(0.994)PPPS(0.003)PAMPK;ALSGGGS(0.012)VAS(0.977)PPPS(0.011)PAMPK;ALSGGGS(0.004)VAS(0.996)PPPSPAMPK 188.04 2.5863e-15 26138500.0 144686.0 121675.0 144379.0 155739.0 167743.0 113514.0 122273.0 133389.0 111525.0 147317.0 True False 136644.93134394876 131007.08125321075 135089.8123279692 134527.0795352401 146669.6246985532 129149.52312250398 127958.93677935307 133777.13990626216 133833.1162688586 143063.5754344667 0.9551343235269683 0.9157263185640241 0.944264198051236 0.9403307524413373 1.025205921585109 0.9027421741019163 0.8944200953370368 0.9350887498791864 0.9354800190224778 1.0 17.126296877255015 -5.4213498379243354 14.952026427727661 0.9439606271940287 0.9340700887774064 0.008939647869629974 0.03852115141733323 12.51967143359996 1817.809841113056 0.010418740161782219 0.02168912141563763 3.790095578030328e-06 5.4213498379243354 -0.009890538416622352 ALSGTS(ph)PDDVQPGPSVGPPSK ddPTM_A459_Selumetinib_30min_R1 1 ALSGTSPDDVQPGPSVGPPSK 21 0 A0A075B797;M0R3B2;Q9Y314 A0A075B797 NOSIP Nitric oxide synthase-interacting protein 1 ALSGT(0.116)S(0.884)PDDVQPGPSVGPPSK 182.98 6.111e-17 0.0 2021.8 2040.4 1864.4 2016.7 1967.9 1914.4 1661.4 1676.1 1144.2 1571.0 True False 2068.9040062620297 1801.5090194437748 1611.224720416135 1664.521203147525 1789.9037924609634 1895.1428741361246 1536.0792603991863 1631.6443832599032 1941.6238309384391 1772.6531528358632 1.1671228536458071 1.0162783489605671 0.9089339997723314 0.9389999394323981 1.0097315369323676 1.0690996550026182 0.8665424806549382 0.9204532655751767 1.095320778253918 1.0 10.791694562785064 -4.800129683122329 3.5860234781122307 0.972040109726183 1.1854554779776507 0.4143511157323655 0.06771621061948425 0.2559820372930081 5.577375686157867 0.017365021718368134 0.14323930552500427 1.584420003824136e-05 4.800129683122329 0.21341536825146767 ALSGTS(ph)PDDVQPGPSVGPPSK ddPTM_A459_Selumetinib_30min_R2 2 ALSGTSPDDVQPGPSVGPPSK 21 0 A0A075B797;M0R3B2;Q9Y314 A0A075B797 NOSIP Nitric oxide synthase-interacting protein 1 ALS(0.001)GT(0.106)S(0.894)PDDVQPGPSVGPPSK;ALSGT(0.11)S(0.889)PDDVQPGPSVGPPSK 218.14 2.2037e-20 19097000.0 93089.0 90274.0 97814.0 109223.0 103692.0 85230.0 90901.0 87396.0 78691.0 96460.0 True False 87915.48604479243 97197.72552333973 91520.75373183076 94346.63897981553 90665.2839417585 96969.6588590925 95128.07661691429 87650.30789081324 94431.39881024635 93674.94916682177 0.9385165065659918 1.037606386636457 0.9770035056954801 1.007170431571813 0.9678711837921206 1.0351717265029237 1.0155124445010875 0.9356856733887361 1.0080752607837284 1.0 16.515375669218393 ALSIES(ph)LSPTDSSNGVNWR ddPTM_A459_Selumetinib_30min_R2 1 ALSIESLSPTDSSNGVNWR 19 0 H3BRG5;Q9Y3M8-5;Q9Y3M8-3;Q9Y3M8-4;Q9Y3M8-2;Q9Y3M8 H3BRG5 STARD13 StAR-related lipid transfer protein 13 1 ALS(0.33)IES(0.67)LSPTDSSNGVNWR 113.67 0.00052082 3725700.0 4804.6 6865.6 7226.2 7300.2 6896.9 6344.3 4918.2 7856.9 7539.0 7343.4 True False 4537.579566337696 7392.169443616554 6761.274159291679 6305.900166452582 6030.449762931697 7218.169737178695 5146.906045228418 7879.762278220184 9047.010657260023 7131.376961555442 0.6362837907460712 1.0365697232760265 0.9481021962155484 0.8842472078600073 0.8456220720684468 1.012170549403172 0.7217268240025576 1.104942610760757 1.268620451005686 1.0 12.799964950925938 -7.904207366656808 7.442208043728878 1.1512549942872614 0.8843808809605337 0.44303442644337254 0.13032735968251796 0.19289706147038352 12.813824477732792 0.06771145171330244 0.03230306070162572 1.2467880565156887e-08 7.904207366656808 -0.2668741133267277 ALSIS(ph)PLSDASLDLQR ddPTM_A459_Selumetinib_30min_R1 1 ALSISPLSDASLDLQR 16 0 P10070 P10070 GLI2 Zinc finger protein GLI2 1 ALS(0.318)IS(0.628)PLS(0.003)DAS(0.051)LDLQR 105.58 0.0036426 2202300.0 798.72 559.86 846.44 724.36 540.01 615.5 749.7 637.05 449.13 425.85 True False 817.3286219614242 494.3113309281474 731.4980971621075 597.8641239212285 491.16619084650904 609.308628829286 693.149525413067 620.1533645699673 762.1408068426684 480.51199563026904 1.700953627368586 1.0287179829502036 1.522330563678498 1.2442230981914055 1.0221725894735787 1.268040411832132 1.442522833387103 1.290609537763019 1.5861015204063693 1.0 8.908428637049054 ALSPPYDTENPYS(ph)A ddPTM_A459_Selumetinib_30min_R1 1 ALSPPYDTENPYSA 14 0 F8W0I7 F8W0I7 NTN4 1 ALSPPYDTENPYS(1)A 87.719 0.021702000000000003 4523000.0 715.42 605.06 711.02 428.56 337.99 539.34 448.02 423.63 277.41 329.71 True False 732.0878940350092 534.2192939152374 614.4673893532934 353.7200410675377 307.41886417698095 533.914729281539 414.2254906970288 412.39395625582773 470.7445087752425 372.03149014736647 1.967811632679319 1.4359518160777902 1.6516542433273456 0.9507798410490054 0.8263248470047747 1.4351331632439193 1.113415131963557 1.108492069024784 1.265335116091314 1.0 8.539280931421677 -5.750698927884713 24.961862960745663 1.1075752436874826 1.660220735724715 0.6462371905857386 0.1981056554156787 137.65325697211094 319916.6618513004 0.05424202914127829 0.09274395790315612 1.775419853819797e-06 5.750698927884713 0.5526454920372323 ALSQTVPSSGTNGVSLPADCT(ph)GAVPAASPDTAAWR ddPTM_A459_Selumetinib_30min_R2 1 ALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWR 35 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EN31 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ALSQTVPSSGTNGVS(0.006)LPADCT(0.629)GAVPAAS(0.336)PDT(0.028)AAWR 121.11 3.1592e-19 6628100.0 62864.0 53799.0 67302.0 70627.0 72750.0 54993.0 60719.0 60506.0 54671.0 56488.0 True False 59370.270544530795 57925.21030894997 62971.86259287711 61007.48076162931 63610.49460674809 62567.786573249665 63542.553812415936 60682.0624426925 65606.7276353712 54857.044666550064 1.0822724939962496 1.0559302029675466 1.1479266332273852 1.112117525332705 1.1595683834848578 1.1405606509349808 1.1583298772046682 1.106185409942332 1.1959581132042996 1.0 15.743389280996325 -5.26077571542383 24.999746972345488 1.1335250588029413 1.0691013446356448 0.17285976709018103 0.04982967425127709 80.09471501856228 3016981.9115958265 0.01167731120810677 0.027494917033797632 5.485601870898535e-06 5.26077571542383 -0.06442371416729653 ALSQTVPSSGTNGVSLPADCTGAVPAAS(ph)PDTAAWR ddPTM_A459_Selumetinib_30min_R1 2 ALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWR 35 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EN31 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ALSQTVPSSGTNGVS(0.002)LPADCT(0.181)GAVPAAS(0.81)PDT(0.006)AAWR;ALSQTVPSSGTNGVSLPADCTGAVPAAS(0.966)PDT(0.033)AAWR 146.94 1.2225e-27 15371000.0 4024.2000000000003 4682.7 4680.4 5367.2 4392.1 3804.5 4713.5 4137.0 2236.6000000000004 4190.200000000001 True False 4117.956030269888 4134.447307071832 4044.8273875969126 4429.919274821934 3994.8353304882357 3766.2301842096176 4357.9569001393775 4027.2733211301384 3795.3468451991926 4728.052986004355 0.8709623268731479 0.8744502904917368 0.8554953592039094 0.9369436611508087 0.8449218615598137 0.7965710611446495 0.9217233633039837 0.8517826117963113 0.8027293383627272 1.0 12.207030488159212 -10.590371175060584 4.524936359440693 1.0000073291186875 0.8631949361812385 0.49307811828713755 0.04203537286278294 3.5068790423384666e-06 7.226805045408542e-07 0.040787795271874025 0.009891896785444892 2.568199901255615e-11 10.590371175060584 -0.13681239293744896 ALSQTVPSSGTNGVSLPADCTGAVPAAS(ph)PDTAAWR ddPTM_A459_Selumetinib_30min_R2 1 ALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWR 35 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EN31 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ALS(0.001)QT(0.01)VPS(0.307)S(0.089)GT(0.034)NGVS(0.028)LPADCT(0.019)GAVPAAS(0.47)PDT(0.041)AAWR 45.2 0.013038 3675500.0 13005.0 13449.0 15742.0 15020.0 15598.0 13855.0 11776.0 14660.0 13747.0 18332.0 True False 12282.234163139847 14480.49505464913 14729.176858593675 12974.250089054785 13638.439792110747 15763.40048683241 12323.607333701313 14702.658172906355 16496.7841232728 17802.70752774386 0.6899082144667675 0.8133872351765948 0.8273559982738371 0.728779601014937 0.7660879543662956 0.8854496127775295 0.6922321963946282 0.8258664110497593 0.9266446745566145 1.0 14.119809049943445 -8.327105485576764 2.382057576011943 0.994826670731435 0.7772297350966904 0.6347845651001238 0.05811291347877618 0.17774909768130445 1.9014910655822967 0.05315759751242981 0.014965599160700697 4.7086294483342646e-09 8.327105485576764 -0.2175969356347447 ALSS(ph)DSILSPAPDAR ddPTM_A459_Selumetinib_30min_R2 3 ALSSDSILSPAPDAR 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 ALS(0.095)S(0.789)DS(0.111)ILS(0.005)PAPDAR;ALS(0.234)S(0.481)DS(0.281)ILS(0.004)PAPDAR;ALS(0.101)S(0.896)DS(0.003)ILSPAPDAR 177.39 1.9502e-05 410896600.0 69549.0 49765.0 66907.0 66047.0 62349.0 47733.0 50895.0 54017.0 52274.0 53651.0 True False 65683.74500670611 53581.81548030437 62602.27646283367 57051.28466256998 54516.1612128679 54307.787472967975 53261.71834652927 54174.18052700423 62730.26065759529 52101.956227961295 1.2606771369451182 1.0284031418296131 1.2015340880662984 1.094993140237459 1.0463361677696659 1.0423368219679798 1.0222594735885477 1.0397724855085355 1.2039905062898608 1.0 15.66904992071726 -3.301340901517997 2.399481728883684 1.0776162325270093 158.61689440989355 0.38038327114851933 0.0693462573911683 1305.2249858359776 10.788323122525124 0.017991400418828036 1130087.7358039021 0.0004996421845006563 3.301340901517997 157.53927817736653 ALSSDS(ph)ILSPAPDAR ddPTM_A459_Selumetinib_30min_R1 2 ALSSDSILSPAPDAR 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 ALS(0.098)S(0.247)DS(0.651)ILS(0.005)PAPDAR;ALS(0.056)S(0.056)DS(0.883)ILS(0.004)PAPDAR 195.94 3.3025e-05 912929000.0 3194.0 3403.7 3272.9 3891.7 3823.4 2795.5 3444.6000000000004 3262.1 1730.88 2465.1000000000004 True False 3268.4139855578796 3005.193221662799 2828.4581567528267 3212.08765125662 3477.574145076095 2767.379808110915 3184.771048736631 3175.5785112058556 2937.1769415265917 2781.5195971073767 1.1750461830133592 1.0804141825166467 1.016875149718256 1.1547959808002108 1.250242546805198 0.9949165236832535 1.1449752329800635 1.141670371299299 1.0559612610966644 1.0 11.441657554751197 -8.50789329364286 3.941338085255879 1.0003017981553763 1.1169916376082516 0.22919477648946207 0.07090249722428255 0.2870889250246758 11.997899063638375 0.06883276077838063 0.01805963154181549 3.105322473586668e-09 8.50789329364286 0.11668983945287525 ALSSDSILS(ph)PAPDAR ddPTM_A459_Selumetinib_30min_R1 3 ALSSDSILSPAPDAR 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 ALSSDS(0.001)ILS(0.999)PAPDAR;ALSS(0.001)DS(0.005)ILS(0.995)PAPDAR;ALS(0.016)S(0.061)DS(0.024)ILS(0.899)PAPDAR 225.21 3.097e-10 92591700.0 6622.1 7239.3 7791.4 7223.5 6380.200000000001 6032.700000000001 6487.9 7535.4 5214.6 4960.799999999999 True False 6776.3820456364565 6391.719390540738 6733.370675096693 5962.051326888557 5803.112036515799 5972.016515253348 5998.512479561742 7335.53671357119 8848.795340684837 5597.567002283996 1.2105941818778523 1.1418745658484661 1.202910241601262 1.0651147765548568 1.0367204240963859 1.0668950479407509 1.0716285266642003 1.3104866293834525 1.5808288381495443 1.0 12.45058417675011 -7.8076319027668495 6.722278581840677 1.3374996576886768 1.1116123872399688 0.24436238218318107 0.14283474046328345 0.233045795778364 25.0492017879904 0.07490514039520783 0.03611013925502009 1.5572849885374398e-08 7.8076319027668495 -0.22588727044870804 ALSSDSILS(ph)PAPDAR ddPTM_A459_Selumetinib_30min_R2 3 ALSSDSILSPAPDAR 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 ALSSDS(0.004)ILS(0.996)PAPDAR;ALSSDS(0.001)ILS(0.999)PAPDAR;ALSS(0.004)DS(0.191)ILS(0.804)PAPDAR 143.58 0.00037681 41676000.0 79913.0 77904.0 90244.0 93614.0 80874.0 73864.0 85791.0 87149.0 72038.0 109164.0 True False 75471.75537708536 83878.98629915851 84437.79929023798 80863.61170684235 70713.88509726663 84038.09552936768 89780.45149164149 87402.58916170638 86447.61290989498 106012.15167786581 0.7119160792662511 0.7912204871950688 0.7964917035814459 0.7627768178176294 0.6670356556118361 0.7927213456126269 0.8468883054506163 0.8244582133121169 0.8154500360730278 1.0 16.693870118098864 -9.220820299499815 0.4015848383458418 1.0283032244948354 0.7478131781804199 0.7333680754111194 0.04320015496649585 1.7147088421597567 0.45857667705577004 0.13638078392240632 0.03391815524279159 6.014225400337503e-10 9.220820299499815 -0.28049004631441543 ALSSGGS(ph)ITSPPLSPALPK ddPTM_A459_Selumetinib_30min_R2 1 ALSSGGSITSPPLSPALPK 19 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9JW88;C9JRZ2;C9J0V6;C9JXQ0;C9JPV7;F8WCD5;C9JHT0 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 ALS(0.001)S(0.006)GGS(0.907)IT(0.076)S(0.009)PPLSPALPK 129.05 0.00031567 244820000.0 224000.0 201860.0 230170.0 247700.0 219920.0 178010.0 190370.0 235320.0 203260.0 238280.0 True False 211550.97674304683 217342.01291779874 215361.11279014742 213962.83269366669 192291.68349025477 202529.26168610892 199222.58221099872 236004.74224067657 243917.6795589163 231400.23727420915 0.9142210882539374 0.9392471480495872 0.9306866549792887 0.9246439641292193 0.8309917299799016 0.8752335955736806 0.8609437248541801 1.0198984453114932 1.054094336428333 1.0 17.82003081820006 -7.774340304054302 23.721465674393137 1.0277474660997818 0.8972579623099467 0.7473402487915553 0.034115990140337143 68.67144736705814 126265.56014064439 0.02059008691916129 0.010005881232073058 1.6813560693835865e-08 7.774340304054302 -0.13048950378983515 ALSSGGSIT(ph)SPPLSPALPK ddPTM_A459_Selumetinib_30min_R1 1 ALSSGGSITSPPLSPALPK 19 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9JW88;C9JRZ2;C9J0V6;C9JXQ0;C9JPV7;F8WCD5;C9JHT0 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 ALSSGGS(0.003)IT(0.498)S(0.498)PPLSPALPK 172.24 5.4214e-09 437800000.0 4226.8 5174.1 6157.4 6604.0 4930.4 4603.7 6336.4 5455.0 3132.4 4021.7 True False 4325.27621607891 4568.313966626171 5321.25890017717 5450.735372433311 4484.446190532818 4557.390957825155 5858.440246535094 5310.315679662775 5315.454018555819 4537.924369675362 0.9531397757491351 1.0066968055161711 1.1726195649571496 1.201151656219262 0.9882152775617171 1.004289755968583 1.2909955674193399 1.1702080614540231 1.1713403718396658 1.0 12.147816849511136 -7.239656543593372 24.986462647247038 1.1723200330580252 1.0612282662614025 0.2000789980694292 0.09949863344139752 1278.9504337129636 1467049.1086998282 0.03950605179864506 0.030575479983222475 5.758951968717443e-08 7.239656543593372 -0.11109176679662269 ALSSGGSIT(ph)SPPLSPALPK ddPTM_A459_Selumetinib_30min_R2 1 ALSSGGSITSPPLSPALPK 19 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9JW88;C9JRZ2;C9J0V6;C9JXQ0;C9JPV7;F8WCD5;C9JHT0 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 ALSSGGS(0.001)IT(0.878)S(0.121)PPLSPALPK 132.51 0.00057423 227260000.0 122570.0 113640.0 125760.0 124160.0 131770.0 102590.0 103860.0 123440.0 110790.0 124190.0 True False 115758.05008658589 122355.82258980797 117668.73851713496 107249.19381205346 115215.87456125366 116720.8412807028 108689.69579468576 123799.1899634078 132951.0957312429 120604.3120156289 0.959816843626495 1.0145227856691568 0.9756594648281438 0.8892650023836232 0.955321353239203 0.9677999014295373 0.9012090362125764 1.0264905781093872 1.1023743140627842 1.0 16.879921963866792 -7.938752318113407 6.850161953508428 1.0555909394279746 0.953867043168762 0.5158880595074229 0.040777734920774265 0.1560247910950546 13.810893546252634 0.02301486517547772 0.010890432307188225 1.1514568875116074e-08 7.938752318113407 -0.10172389625921252 ALSSGGSITS(ph)PPLSPALPK ddPTM_A459_Selumetinib_30min_R1 2 ALSSGGSITSPPLSPALPK 19 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9JW88;C9JRZ2;C9J0V6;C9JXQ0;C9JPV7;F8WCD5;C9JHT0 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 ALSSGGS(0.001)IT(0.084)S(0.907)PPLS(0.008)PALPK;ALSSGGSIT(0.003)S(0.993)PPLS(0.003)PALPK 200.58 1.8883e-15 435770000.0 4127.38 4861.94 4948.09 5728.01 4560.11 4310.97 5035.9800000000005 4921.16 1937.1499999999999 3155.58 True False 4223.539923516557 4292.701804545417 4276.166555912829 4727.7205815644675 4147.64885565281 4267.605555847584 4656.11197410924 4790.634850619477 3287.202066161858 3560.6294309521313 1.186177895065918 1.2056019554378412 1.200958043749405 1.3277766398454585 1.1648639478171439 1.1985536935547947 1.3076654182640317 1.3454460632648413 0.9232081377485112 1.0 11.797916581091332 -8.269884677011918 24.999112231096554 0.9616040211542495 1.2405516897213968 0.7620864054878949 0.06269123223660317 332.73639304042763 984927.9958769075 0.058912699595933406 0.01620101118818529 5.371744192621351e-09 8.269884677011918 0.27894766856714737 ALSSGGSITSPPLS(ph)PALPK ddPTM_A459_Selumetinib_30min_R2 2 ALSSGGSITSPPLSPALPK 19 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9JW88;C9JRZ2;C9J0V6;C9JXQ0;C9JPV7;F8WCD5;C9JHT0 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 ALSSGGSITS(0.008)PPLS(0.991)PALPK;ALSSGGSITSPPLS(1)PALPK 209.45 9.5094e-22 4537000.0 64449.0 53526.0 52046.0 66292.0 67100.0 44854.0 45020.0 46259.0 49886.0 72113.0 True False 60867.18258978853 57631.2720867833 48697.41702340022 57262.91523992144 58670.298118389 51032.23135592791 47113.5192054376 46393.6060314103 59864.59393130043 70030.91031792451 0.869147385254101 0.8229404962058945 0.695370327221579 0.8176805781898414 0.8377771737085681 0.7287100956456671 0.6727532027150992 0.6624732681724943 0.8548310118992983 1.0 16.09570422045597 -8.53192659665113 21.932660867511114 1.0000000034682666 0.7629091632350169 0.5304723416921814 0.06887814201555653 183.1642320197501 444005.8104769919 0.0717081314936185 0.018514959933073984 2.9381462079970542e-09 8.53192659665113 -0.23709084023324967 ALSSLHGDDQDS(ph)EDEVLTIPEVK ddPTM_A459_Selumetinib_30min_R1 3 ALSSLHGDDQDSEDEVLTIPEVK 23 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(0.986)EDEVLT(0.013)IPEVK 152.17 3.237e-08 15729000.0 14998.58 11558.93 17700.399999999998 12908.7 19716.8 14836.42 17180.64 16401.98 3793.8599999999997 9052.92 True False 15348.017731843684 10205.605101999228 15296.782901337576 10654.437871309787 17933.418921283774 14687.179085191536 15884.690492587384 15966.946209260353 6437.903327428866 10214.950464908241 1.5025053508158692 0.9990851289058016 1.4974896798459398 1.0430239390696343 1.7556050793286804 1.437812071203565 1.5550433207832568 1.5630958039505072 0.6302432253142303 1.0 13.318394587614275 -8.259490355508674 24.991882993851604 0.8151215848601958 1.4116346838936464 0.5135766825726996 0.23506746362192046 131.72334268280508 1689117.2453833646 0.1757934485277701 0.05875611944114667 5.501861385027525e-09 8.259490355508674 0.5965130990334506 ALSSLHGDDQDS(ph)EDEVLTIPEVK ddPTM_A459_Selumetinib_30min_R2 8 ALSSLHGDDQDSEDEVLTIPEVK 23 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(1)EDEVLTIPEVK;ALSSLHGDDQDS(0.986)EDEVLT(0.014)IPEVK;ALSSLHGDDQDS(0.998)EDEVLT(0.001)IPEVK;ALSSLHGDDQDS(1)EDEVLTIPEVK 130.89 3.3771e-06 17881200.0 182747.8 105089.00000000001 174232.6 263595.0 217965.0 157665.5 211089.6 199674.4 183568.0 198954.5 True False 172591.40887340624 113148.9883856064 163022.66420611113 227692.9062732625 190582.28806817663 179382.49148009197 220905.68466610697 200255.41944612353 220286.72931846554 193210.1666391295 0.8932832670020198 0.5856264727359908 0.8437582092178337 1.178472697549806 0.9863988597667269 0.9284319484861047 1.1433439994837649 1.036464193005707 1.1401404654337295 1.0 17.559811484624746 -5.576535631969041 5.852291921036717 1.0543469620493853 0.7329179497429588 0.6340205868672791 0.10108620476707798 0.10608128619768371 7.7790207552964645 0.026450040080524657 0.046906687479961455 2.651333553725003e-06 5.576535631969041 -0.3214290123064265 ALST(ph)TSSSTTNGNR ddPTM_A459_Selumetinib_30min_R2 1 ALSTTSSSTTNGNR 14 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 ALS(0.301)T(0.68)T(0.015)S(0.001)S(0.001)S(0.001)TTNGNR 128.35 0.0026691 4660700.0 19497.0 16745.0 18537.0 21423.0 27959.0 15369.0 21506.0 20224.0 16039.0 19343.0 True False 18413.434792674943 18029.28765633873 17344.349601559585 18505.150443263705 24446.540463368678 17485.940244108795 22506.07161333055 20282.848491736557 19247.248167103528 18784.517330850413 0.9802452982081137 0.9597950982072163 0.9233321940657163 0.9851278112359111 1.3014196762574965 0.9308698188050367 1.1981181745015141 1.0797641554742206 1.0246336292864526 1.0 14.19725642588129 -6.022493940908191 24.971433870637334 1.0954416393767912 0.9548643677950382 0.28966192678648506 0.09802283035160327 865.4801344780088 960804.1168559792 0.027177089714716822 0.03536936782488179 9.495242464680293e-07 6.022493940908191 -0.14057727158175293 ALSYAS(ph)LDKEDLLSPINQNTLQR ddPTM_A459_Selumetinib_30min_R1 1 ALSYASLDKEDLLSPINQNTLQR 23 1 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 ALS(0.084)Y(0.217)AS(0.699)LDKEDLLSPINQNTLQR 70.501 0.0013212 10037000.0 873.84 1065.1 952.97 1061.1 985.52 1008.2 1005.8 934.73 589.11 985.8 True False 894.1987718033491 940.3975968484434 823.5619082895109 875.7988043138985 896.379890007688 998.0584233723582 929.9316962257745 909.9379239690528 999.6766431079748 1112.3370325051526 0.8038919371312103 0.8454250549678497 0.7403888248103401 0.7873502173540569 0.8058527800597485 0.8972626049539846 0.8360161255545242 0.818041562384859 0.8987173976007529 1.0 10.119378268274737 -9.35591347482646 0.31873380989307853 1.042730632809732 0.7887588525797751 0.7143050184984996 0.03699677219476947 2.5855536353140636 0.4281514776249051 0.19054579480687128 0.04414235675919564 4.4064264468988e-10 9.35591347482646 -0.25397178022995703 ALT(ph)PLTSSYR ddPTM_A459_Selumetinib_30min_R1 1 ALTPLTSSYR 10 0 O95486-2;O95486 O95486-2 SEC24A Protein transport protein Sec24A 1 ALT(0.944)PLT(0.043)S(0.004)S(0.009)YR 116.84 0.014525 12542000.0 3340.5 3601.5 4283.2 4294.8 3168.8 3286.7 3363.6 3275.5 1797.0 2480.7 True False 3418.3271505185007 3179.8347057080746 3701.564965933486 3544.793803380766 2882.182599497079 3253.6387820848313 3109.880943950103 3188.623099676519 3049.377752312861 2799.122009064244 1.2212140590689218 1.136011469100307 1.3224021510841293 1.26639488807628 1.0296738013433728 1.1623783356169364 1.1110201462742764 1.139151165740891 1.089405085751256 1.0 11.450758657616367 -6.250867132081036 24.921202113025185 1.1003717617444073 1.2354629566558089 0.5681871373538034 0.06266087362924336 564.1045247519294 1329723.3551038157 0.018636124665574436 0.023790923224592416 5.612196491355454e-07 6.250867132081036 0.13509119491140154 ALT(ph)PLTSSYR ddPTM_A459_Selumetinib_30min_R2 1 ALTPLTSSYR 10 0 O95486-2;O95486 O95486-2 SEC24A Protein transport protein Sec24A 1 ALT(0.961)PLT(0.039)SSYR 121.29 0.011281 5638800.0 25976.0 19628.0 26329.0 28693.0 32336.0 19426.0 25481.0 25285.0 16840.0 25029.0 True False 24532.357910166913 21133.40448603264 24635.020804847703 24784.963901814186 28273.662592492205 22101.755168329582 26665.91698964362 25358.575163842925 20208.470548913498 24306.347736848194 1.0092984012145967 0.8694603037376363 1.0135221083627157 1.019690994720709 1.1632213485380858 0.9092997190533701 1.0970762567186654 1.0432902317693564 0.8314071191484538 1.0 14.569045510358132 -5.403007624508614 11.300763653318782 1.0168455954883593 0.9394313578556224 0.08154939393170468 0.091970218045752 1.096665009749002 98.08141877244218 0.02343360937413878 0.04880282573404837 3.953596790410942e-06 5.403007624508614 -0.07741423763273692 ALT(ph)TPTHYK ddPTM_A459_Selumetinib_30min_R2 1 ALTTPTHYK 9 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4;H0YCR0 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ALT(0.936)T(0.063)PT(0.001)HYK 98.04 0.027188 20961000.0 140800.0 149810.0 191920.0 185530.0 183390.0 141360.0 144280.0 134500.0 133970.0 158100.0 True False 132974.8996670582 161299.94528492723 179572.07614669667 160260.49394289876 160350.9086725984 160831.05686168364 150989.3058853964 134891.37273232642 160767.74343455673 153535.24220686805 0.8660871455681325 1.0505727738234671 1.1695821334931527 1.0438026581999287 1.0443915440374736 1.0475188272734508 0.9834179027246309 0.878569446294151 1.0471064566267063 1.0 17.228210321702228 -7.328528624754692 4.712018246573045 0.9653451596602828 1.044349153606713 0.11102353172421997 0.0794003351682399 0.4139031746398413 18.11882340844917 0.034849385522491706 0.023267455030772335 4.693224998136962e-08 7.328528624754692 0.07900399394643032 ALTQPS(ph)PVSTPSSVQFFLQEDDSADR ddPTM_A459_Selumetinib_30min_R1 1 ALTQPSPVSTPSSVQFFLQEDDSADR 26 0 P04920-2;P04920-3;P04920;C9J9M9 P04920-2 SLC4A2 Anion exchange protein 2 1 ALT(0.005)QPS(0.982)PVS(0.011)T(0.002)PSSVQFFLQEDDSADR 154.26 6.7307e-12 7414400.0 2284.5 1739.1 2669.3 1532.9 2918.1 1926.0 2160.4 2391.4 1077.5 1807.5 True False 2337.724405136811 1535.4853635143434 2306.823721415356 1265.207791096762 2654.1583702323996 1906.6261886680816 1997.4392886519827 2327.9723036380506 1828.4388025136943 2039.5102315409456 1.146218522949282 0.7528696545710448 1.13106749146948 0.6203488325434083 1.3013704609988932 0.9348451207462373 0.9793720363652325 1.141436933061698 0.8965087667798671 1.0 10.99400702932935 -6.271798112952638 24.999578194992065 1.0408126761784047 0.9168178911062843 0.10905200932054249 0.18133104592755311 1658.1105232621446 4001645.9180870703 0.0521945381671255 0.05982026772189846 5.348129158784949e-07 6.271798112952638 -0.12399478507212036 ALTQTGGPHVK ddPTM_A459_Selumetinib_30min_R2 1 ALTQTGGPHVK 11 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 94.122 0.031803 6937600.0 58182.0 45838.0 49531.0 58835.0 53004.0 45572.0 59800.0 49897.0 40807.0 45421.0 False True 54948.477360999816 49353.62720759958 46344.229385275234 50821.57150396392 46345.16365822787 51849.12933857281 62580.818491452024 50042.192009107 48969.540242845214 44109.57771206928 1.245726670059795 1.1188868669240382 1.0506613708204808 1.1521663579666985 1.050682551548139 1.1754619297655582 1.4187580506881305 1.1344971909675399 1.1101793030642901 1.0 15.428804328244832 -6.980778357634451 24.44949391842248 1.1942157762493166 1.1201115025287078 0.013158047573090137 0.111901440046581 490.2904758832501 623635.2701956973 0.03959752327295051 0.03491619498372434 1.0452535286855407e-07 6.980778357634451 -0.0741042737206088 ALTVPELTQQVFDAK ddPTM_A459_Selumetinib_30min_R1 2 ALTVPELTQQVFDAK 15 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 ; 221.86 2.1546e-08 19867000.0 9911.599999999999 9472.6 11170.2 10720.9 11526.099999999999 10890.4 9917.0 9349.3 7759.6 9193.2 False True 10142.520995383684 8363.54358830773 9653.348193516582 8848.696071217482 10483.566290098235 10780.852463692048 9168.9527057775 9101.326193193616 13167.474461239226 10373.236769351159 0.9777585551070087 0.8062617073408289 0.9306013550214562 0.8530313409370839 1.0106359782583056 1.0392949378679213 0.8839046972173772 0.8773853711779201 1.2693698942787022 1.0 13.340578509233378 -7.422344624766087 0.5872356790792226 1.067055963436473 0.8927986249265203 0.21967785449542454 0.10990688477936537 1.3183577383218867 0.9314408151535776 0.10244392400142258 0.07042565610045433 3.781423991054204e-08 7.422344624766087 -0.17425733850995262 ALVADSHPESER ddPTM_A459_Selumetinib_30min_R2 1 ALVADSHPESER 12 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 90.434 0.043 0.0 24734.0 19777.0 23989.0 27081.0 29056.0 21054.0 19167.0 20258.0 19932.0 21926.0 False True 23359.383298046963 21293.832306922115 22445.57385724834 23392.5210826693 25405.725516064227 23953.997390817003 20058.303478689984 20316.947426107563 23918.95694661187 21292.93940941042 1.097048314885228 1.0000419339713755 1.0541322372489592 1.098604595302186 1.1931525764280417 1.1249737262780415 0.9420166512954623 0.9541635861288593 1.1233280894999813 1.0 14.3780875016582 -10.70098882156735 5.907067547502047 0.999999125360233 1.0626314835225685 0.06167052060910028 0.07575479085363533 9.528162919701973e-07 1.3254232342885453e-07 0.08009335753347584 0.01942522130706634 1.9907245781697258e-11 10.70098882156735 0.06263235816233548 ALVAT(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 ALVATPGK 8 0 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 ALVAT(1)PGK 107.55 0.030992 72990000.0 10075.0 11868.0 12922.0 13946.0 10298.0 9944.6 10312.0 9042.3 6472.0 8355.7 True False 10309.727897462633 10478.48904271648 11167.263375465187 11510.59289884236 9366.547718259573 9844.566352974352 9534.157537761175 8802.46883047015 10982.511303822392 9428.235486410336 1.0934949506005511 1.1113944977106223 1.1844489238268867 1.2208639586308054 0.9934571247992608 1.0441578773848095 1.0112345572513026 0.9336284443847257 1.1648533089412496 1.0 13.202772077492172 -6.272725103680028 24.98143099306333 1.0215507371469132 1.1518893165386233 0.4891507399122432 0.0640347693256827 624.888149490627 1383213.3834280188 0.019707421386818944 0.02254667078995877 5.336725884968111e-07 6.272725103680028 0.13033857939171 ALVATPGKK ddPTM_A459_Selumetinib_30min_R2 1 ALVATPGKK 9 1 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 0 110.41 0.010375 0.0 46226.0 48400.0 46036.0 53674.0 50778.0 44746.0 41320.0 43293.0 40761.0 54372.0 False True 43656.943977339644 52112.12436947118 43074.09388020695 46363.50860718551 44398.81367892035 50909.355336254244 43241.4618740267 43418.975462458024 48914.338957497785 52802.13908457832 0.8268025639531398 0.9869320689072487 0.8157641835534539 0.8780611810616341 0.8408525572761826 0.9641532752055325 0.8189339035064972 0.8222957670883301 0.9263704047888465 1.0 15.688308755803678 -8.540493252918612 7.58618454836604 0.9999969912469474 0.8722738909282768 0.335387833882116 0.057631659456608024 0.24593447054790427 95.46027404203964 0.053464637412790755 0.013824168424906335 2.880757804100028e-09 8.540493252918612 -0.12772310031867062 ALVEFESNPEET(ph)REPGSPPSVQR ddPTM_A459_Selumetinib_30min_R2 3 ALVEFESNPEETREPGSPPSVQR 23 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 ALVEFES(0.015)NPEET(0.445)REPGS(0.445)PPS(0.095)VQR;ALVEFES(0.003)NPEET(0.779)REPGS(0.195)PPS(0.023)VQR;ALVEFES(0.057)NPEET(0.819)REPGS(0.099)PPS(0.025)VQR 69.07 0.0040908 29903600.0 38263.7 32265.0 36554.7 42829.4 39277.6 34649.0 35151.3 41461.2 31017.2 36603.5 True False 36137.15673572734 34739.62175167329 34202.81039974804 36995.96183516401 34343.19674180082 39421.5852376944 36785.90510097953 41581.845227728845 37221.5066929786 35546.66184768562 1.016611823933621 0.9772963183021115 0.9621947215832569 1.0407717606139366 0.9661440753271984 1.1090094874903444 1.0348624368331396 1.1697820010751916 1.0471167968590003 1.0 15.117426463672269 -6.76065524836488 24.999842013095144 1.0804347916729045 0.9927399347187337 0.4000482536449115 0.04817874018197385 19.15906667421915 610840.788740984 0.015501155006516096 0.014644923303468341 1.7351808724247062e-07 6.76065524836488 -0.08769485695417079 ALVEFESNPEETREPGS(ph)PPSVQR ddPTM_A459_Selumetinib_30min_R1 5 ALVEFESNPEETREPGSPPSVQR 23 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 ALVEFES(0.001)NPEET(0.026)REPGS(0.933)PPS(0.041)VQR;ALVEFES(0.042)NPEET(0.065)REPGS(0.871)PPS(0.023)VQR;ALVEFES(0.001)NPEET(0.162)REPGS(0.827)PPS(0.01)VQR;ALVEFES(0.021)NPEET(0.022)REPGS(0.871)PPS(0.086)VQR;ALVEFES(0.001)NPEET(0.448)REPGS(0.507)PPS(0.043)VQR 93.255 5.9642e-05 3504357000.0 14670.6 16330.5 15939.1 16611.1 16400.3 14452.899999999998 14971.199999999999 14231.2 8784.5 12459.6 True False 15012.396435981655 14418.517468156522 13774.657767209199 13710.28321396532 14916.895760708145 14307.516948183236 13841.910330617731 13853.742346547542 14906.654905504918 14058.911026781501 1.067820715799667 1.025578541658738 0.9797812747352327 0.9752023601150855 1.061027823015042 1.0176831563218627 0.9845649001014094 0.9854065026912026 1.0602993985173181 1.0 13.779197230211267 -4.840163251365864 3.6313858416659737 1.0074584350644225 1.0709476580136337 0.27248760899747737 0.029455070347574493 0.3333132902044061 7.380000961990265 0.007597421354945354 0.05156983428290203 1.4448965318109382e-05 4.840163251365864 0.06348922294921122 ALVEFESNPEETREPGS(ph)PPSVQR ddPTM_A459_Selumetinib_30min_R2 5 ALVEFESNPEETREPGSPPSVQR 23 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 ALVEFESNPEET(0.006)REPGS(0.941)PPS(0.052)VQR;ALVEFES(0.001)NPEET(0.088)REPGS(0.896)PPS(0.015)VQR;ALVEFES(0.027)NPEET(0.136)REPGS(0.773)PPS(0.065)VQR;ALVEFES(0.047)NPEET(0.341)REPGS(0.607)PPS(0.005)VQR;ALVEFES(0.001)NPEET(0.057)REPGS(0.869)PPS(0.073)VQR 94.234 4.8121e-05 2576274000.0 147896.1 151236.59999999998 158209.69999999998 176238.7 185899.0 135380.4 133368.3 142219.19999999998 124819.8 162718.6 True False 139676.626836997 162835.9609176849 148030.66014769737 152234.68503128507 162544.7056618541 154027.8212390882 139570.19021427285 142633.03432634383 149787.24775660783 158020.49122430442 0.883914647744836 1.030473704113127 0.9367814199335273 0.9633857220149594 1.028630555458328 0.9747332136846178 0.8832410855890707 0.9026236611546875 0.9478976213533611 1.0 17.269752125692648 -7.216037096879026 23.851375934199194 0.9253258785065441 0.9733195365707101 0.10409105137968289 0.04911932873928282 435.00548065817674 228523.1293476126 0.018061454013459106 0.013990218069571096 6.080830573834536e-08 7.216037096879026 0.047993658064166 ALVHQLS(ph)NESR ddPTM_A459_Selumetinib_30min_R2 1 ALVHQLSNESR 11 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 ALVHQLS(0.92)NES(0.08)R 77.91199999999998 0.040756 0.0 12057.0 13042.0 14639.0 14575.0 15175.0 13602.0 16202.0 14178.0 11737.0 13489.0 True False 11386.920207995163 14042.279463360395 13697.142677738075 12589.8598567226 13268.580833778733 15475.55203333774 16955.425103653946 14219.255632705754 14084.727959180378 13099.537521369028 0.8692612383773012 1.071967574462342 1.045620324793466 0.9610919344431054 1.0129045252272417 1.1813815570277015 1.2943529552852444 1.0854776826670522 1.0752080320548896 1.0 13.677228257922458 -6.703650914719631 6.844543318195063 1.1429029645619857 0.9968131595126475 0.3613635124440925 0.08858161817122755 0.23008793009179257 21.504068841687598 0.029935497142261427 0.0297211739752695 1.9785593642906168e-07 6.703650914719631 -0.14608980504933822 ALVHSSSPS(ph)PALNGVR ddPTM_A459_Selumetinib_30min_R2 1 ALVHSSSPSPALNGVR 16 0 O14544;J3KTM7 O14544 SOCS6 Suppressor of cytokine signaling 6 1 ALVHS(0.001)S(0.004)S(0.011)PS(0.984)PALNGVR 62.468 0.043156 3263000.0 7433.9 7784.2 13608.0 10851.0 11767.0 11575.0 7458.3 7871.4 6810.2 7490.6 True False 7020.753598259535 8381.223109852011 12732.476095270136 9373.075080980927 10288.724261685295 13169.351182611697 7805.125728341078 7894.304470819581 8172.43029288662 7274.326915083912 0.9651413361284914 1.1521647580166983 1.7503304764690057 1.2885144138277713 1.4143884900678279 1.8103875913665592 1.0729687872779694 1.085228167907892 1.1234620588662871 1.0 12.828598047982734 ALVILAK ddPTM_A459_Selumetinib_30min_R2 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 140.79 0.043127 3486100.0 44148.0 38748.0 41146.0 45941.0 45436.0 35357.0 40148.0 42451.0 32092.0 38630.0 False True 41694.4308984466 41719.84700554271 38498.71115637751 39683.75654735461 39727.923477006305 40227.10581111028 42014.96155175275 42574.525381858635 38511.29672539974 37514.65152720626 1.1114172516892258 1.1120947498415859 1.0262313413322683 1.057820209753922 1.0589975345551308 1.0723038645830658 1.1199613975164553 1.134877271910226 1.0265668254300775 1.0 15.195166536688426 ALVLDCHYPEDEVGQEDEAES(ph)DIFSIR ddPTM_A459_Selumetinib_30min_R1 2 ALVLDCHYPEDEVGQEDEAESDIFSIR 27 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 1 ALVLDCHYPEDEVGQEDEAES(0.979)DIFS(0.021)IR;ALVLDCHYPEDEVGQEDEAES(0.999)DIFS(0.001)IR 216.97 1.423e-44 33424000.0 4126.5 4815.1 4019.2 5064.8 4526.4 4785.9 3740.0 3578.0 2087.33 2474.1 True False 4222.639421228736 4251.34585352074 3473.414715885288 4180.327758070903 4116.987919200827 4737.758191249519 3457.8887889087255 3483.099817018039 3542.0465574486375 2791.6748347747994 1.5125828297153276 1.5228657007483073 1.2442046160313236 1.497426457407646 1.4747376262869591 1.6971024462566777 1.2386431062225298 1.2476738958385947 1.2687890843613847 1.0 11.446915195558772 -8.192514686793706 0.8976033217082459 1.0271277700075179 1.4750052599300536 0.5814872387968627 0.1249565074916961 0.41081350199403843 0.6805118348238798 0.12200085498442434 0.045043268556681844 6.4192651273190645e-09 8.192514686793706 0.44787748992253573 ALVLDCHYPEDEVGQEDEAESDIFS(ph)IR ddPTM_A459_Selumetinib_30min_R1 2 ALVLDCHYPEDEVGQEDEAESDIFSIR 27 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 1 ALVLDCHYPEDEVGQEDEAESDIFS(1)IR;ALVLDCHYPEDEVGQEDEAES(0.003)DIFS(0.997)IR 200.59 3.3059999999999997e-40 9052800.0 3015.2 2920.0 2418.35 3171.9 2628.07 2958.68 2720.2599999999998 2630.4 1481.62 1589.2 True False 3085.4482934421167 2578.125042528828 2089.951353045677 2617.9872089371925 2390.361532523444 2928.9183654665026 2515.0685981061083 2560.6332472566364 2514.200926756696 1793.1893001188766 1.720648396261104 1.4377316674585976 1.1654939904599737 1.4599614266957968 1.3330224156283885 1.6333570389207288 1.4025672570873449 1.4279770948258967 1.4020833866173643 1.0 10.808312080691605 -9.22358578809977 1.3917456483871404 0.9997462284319892 1.440098921218112 0.46475207903068105 0.14309092077643928 5.413336577618261 9.825909030910774 0.14040397851293795 0.04063177630355588 5.976049854866482e-10 9.22358578809977 0.44035269278612266 ALVLDCHYPEDEVGQEDEAESDIFSIR ddPTM_A459_Selumetinib_30min_R1 1 ALVLDCHYPEDEVGQEDEAESDIFSIR 27 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 80.477 0.00014233 11129000.0 1018.5 1430.9 1106.8 1388.6 1134.3 1176.5 1168.1 1107.2 659.43 918.94 False True 1042.2290683439892 1263.369562792637 956.5026392172163 1146.107077250287 1031.7027652769298 1164.665478176532 1079.989276557294 1077.8334593075383 1119.0045471383805 1036.8949002336028 1.0051443671959277 1.2184162179870028 0.9224682646252046 1.1053261781807198 0.9949926121196051 1.1232242321899197 1.0415609878243035 1.0394818790840927 1.0791880130631168 1.0 10.018053954516235 -8.877902883515796 0.0060482189543300605 1.8912827198357823e-07 2.0827798971294245 0.029369730775900993 0.07728305939711062 24172.121644335733 69.2304841914946 12073.136623725393 11762.215833284718 1.3246377161977302e-09 8.877902883515796 2.0827797080011523 ALVLPS(ph)PRPYVR ddPTM_A459_Selumetinib_30min_R2 1 ALVLPSPRPYVR 12 1 P18858-3;P18858;F5GZ28 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 ALVLPS(0.985)PRPY(0.015)VR 81.565 0.020896 3436000.0 11817.0 10832.0 13777.0 11478.0 12861.0 8995.4 8435.7 6670.9 9641.7 11620.0 True False 11160.258447199036 11662.779569630402 12890.602819263426 9914.676599345592 11245.286201201203 10234.434697889004 8827.97676502244 6690.3112145730565 11570.309411606839 11284.500407614209 0.9889900344785011 1.033522012348987 1.1423281805692966 0.8786101503134043 0.9965249497100868 0.9069461941782843 0.7823099336383355 0.592876155160469 1.0253275726588464 1.0 13.462054927861024 -6.87595581531394 2.2138894979058006 0.8176972937375235 1.0153476550180933 0.23759670063360627 0.12835855554089995 0.3716110839435287 3.7189043619478013 0.051672847174829464 0.04419221107203557 1.3305897839652865e-07 6.87595581531394 0.1976503612805698 ALVVPEPEPDS(ph)DSNQER ddPTM_A459_Selumetinib_30min_R1 3 ALVVPEPEPDSDSNQER 17 0 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.997)DS(0.003)NQER;ALVVPEPEPDS(0.933)DS(0.067)NQER;ALVVPEPEPDS(0.997)DS(0.003)NQER 275.74 1.9392e-52 63751600.0 13496.759999999998 16456.3 16523.7 17844.300000000003 16788.5 13211.150000000001 16723.8 14909.099999999999 8333.53 11973.76 True False 13811.20824787669 14529.588745673685 14279.872298187132 14728.12798399632 15269.983139250415 13078.257825764447 15462.310301591371 14513.66223641801 14141.391753050533 13510.70873029914 1.0222415806288274 1.0754127733573 1.0569299200539395 1.090107726988962 1.1302133325549326 0.9679919896752065 1.1444484971329125 1.0742339670064565 1.0466802323505815 1.0 13.721815735550523 -4.7568768349528385 24.234827721720265 1.0694369004674944 1.0222414738897267 0.054873002831799855 0.050589884960444184 269.2188212698403 1429740.9431966697 0.01186034970414341 0.0912742739212658 1.7503430120234438e-05 4.7568768349528385 -0.04719542657776765 ALVVPEPEPDS(ph)DSNQER ddPTM_A459_Selumetinib_30min_R2 3 ALVVPEPEPDSDSNQER 17 0 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.934)DS(0.066)NQER;ALVVPEPEPDS(1)DSNQER;ALVVPEPEPDS(0.976)DS(0.024)NQER 227.41 3.1683e-16 89420400.0 153205.0 152189.0 169042.0 178947.0 186659.0 129862.0 151167.0 155633.0 132092.0 148962.0 True False 144690.47942820762 163861.4069352366 158166.0217590138 154574.10989920664 163209.2276673678 147749.3117301356 158196.56503172786 156085.86626356997 158514.09095885287 144661.08001024346 1.0002032296313705 1.1327262794086257 1.0933557370635838 1.068525894375054 1.1282179536874117 1.021348048277211 1.093566873830376 1.0789762267260656 1.095761838274873 1.0 17.142317302119423 -10.427545900657087 11.897241317548955 1.0000072567862641 1.0810224488118305 0.26360728341744377 0.039598680782464285 0.0 0.0 0.03573788736875035 0.008667710850457939 3.736406331536061e-11 10.427545900657087 0.0810151920255664 ALVVPEPEPDS(ph)DSNQERK ddPTM_A459_Selumetinib_30min_R1 1 ALVVPEPEPDSDSNQERK 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.737)DS(0.263)NQERK 131.48 0.00027237 6305500.0 6554.4 6290.6 6499.1 7380.9 6309.3 5915.8 6199.8 6513.6 4416.6 5535.9 True False 6707.104767357722 5554.093627579398 5616.557917000919 6091.964371652482 5738.624928997389 5856.292423116635 5732.144094512384 6340.838168845357 7494.647624298821 6246.486689232375 1.0737403441392672 0.8891548007543958 0.8991547083070999 0.9752625235164182 0.9186964152008148 0.9375338033156538 0.9176588984642184 1.0151047275543905 1.1998180732887835 1.0 12.60882926464943 -8.006216189041595 5.6404742057152335 1.1037677889248458 0.9416994076997572 0.4655554191975432 0.06657458970627346 0.1234053687605235 13.977113487257942 0.0391237080926263 0.016323476526425133 9.857886441309211e-09 8.006216189041595 -0.1620683812250886 ALVVPEPEPDSDS(ph)NQER ddPTM_A459_Selumetinib_30min_R1 2 ALVVPEPEPDSDSNQER 17 0 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.354)DS(0.646)NQER;ALVVPEPEPDS(0.481)DS(0.519)NQER 318.94 1.658199999999999e-118 65790000.0 10066.1 11856.1 12537.900000000001 12302.5 12234.8 9774.2 12041.8 10862.5 6108.200000000001 9042.0 True False 10300.620544779018 10467.982300248641 10835.322045754914 10154.099321526468 11128.164500229377 9675.880422263539 11133.477331091204 10574.391213627297 10365.1692747231 10202.628776538433 1.0096045607839739 1.0260083483896234 1.062012769755124 0.9952434361697485 1.0907154169736402 0.9483713103934366 1.0912361485398072 1.0364379068602156 1.0159312371100317 1.0 13.316653299809849 ALVVPEPEPDSDS(ph)NQER ddPTM_A459_Selumetinib_30min_R2 3 ALVVPEPEPDSDSNQER 17 0 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.077)DS(0.923)NQER;ALVVPEPEPDS(0.182)DS(0.818)NQER;ALVVPEPEPDS(0.433)DS(0.567)NQER 283.83 4.8549999999999996e-64 84432300.0 177051.0 172291.0 202817.0 206353.0 225540.0 156241.0 158759.0 185745.0 147269.0 167008.0 True False 167211.21421130895 185505.16569711876 189767.97503045292 178247.36542122022 197205.64884681735 177761.77953541535 166141.60807499028 186285.48719826012 176726.91503966434 162186.04510110457 1.0309839795838893 1.1437800680168098 1.1700635212613646 1.0990302236552056 1.215922422449367 1.0960362183108978 1.0243890463659797 1.148591342011776 1.0896554936615859 1.0 17.307290166189652 -8.551749206347308 17.356682587397355 0.9999999962215482 1.1179331507519594 0.2805826289237938 0.05574487856428397 143.58201817651354 86322.04837139216 0.05420683067602825 0.013997374489291807 2.807054170030279e-09 8.551749206347308 0.1179331545304112 ALVVPEPEPDSDS(ph)NQERK ddPTM_A459_Selumetinib_30min_R1 1 ALVVPEPEPDSDSNQERK 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.076)DS(0.924)NQERK 162.44 3.9256e-06 7416900.0 5710.1 6674.0 6367.9 5942.7 5425.0 5625.6 6395.3 6405.7 4056.2 6308.5 True False 5843.13422007954 5892.604977341574 5503.174156370903 4904.9190032948845 4934.309707861542 5569.011571636116 5912.897372114431 6235.800027353954 6883.07514687336 7118.257424993666 0.8208658202726827 0.8278156612672403 0.773106931627413 0.6890617619521183 0.6931906804235775 0.7823560232708319 0.8306664144166847 0.8760290131484676 0.9669606950017664 1.0 12.797308392143991 -7.9488631817565265 1.2965183063972514 0.9974943120057163 0.7612597196831453 0.7965068843291486 0.04368781792699705 0.2247755888855528 0.679596392184423 0.04541111963652572 0.015874827878415782 1.124959320436454e-08 7.9488631817565265 -0.23623459232257094 ALVVPEPEPDSDS(ph)NQERK ddPTM_A459_Selumetinib_30min_R2 2 ALVVPEPEPDSDSNQERK 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 ALVVPEPEPDS(0.023)DS(0.977)NQERK;ALVVPEPEPDS(0.285)DS(0.715)NQERK 161.08 5.7759e-06 33181000.0 151847.0 106290.0 131660.0 144735.0 127359.0 113672.0 141272.0 163210.0 120046.0 111446.0 True False 143407.95163170274 114442.10122378288 123189.13894056909 125021.84331819878 111359.02381609382 129329.2861883228 147841.42792515733 163684.9140791298 144058.5543654907 108228.26440851743 1.3250508304410795 1.057414177795652 1.1382344493262913 1.155168143935973 1.0289273733131215 1.1949677553744893 1.3660149567502664 1.512404499635014 1.3310622243901888 1.0 16.723717790579165 -7.139296162931295 4.323369558334025 1.3441762576960636 1.1351749555294575 0.19970942245657097 0.14207533108220366 0.27505268347959794 8.415570338125374 0.0536886801599835 0.04107740106705204 7.256109652806424e-08 7.139296162931295 -0.20900130216660617 ALYDYAGQEADELS(ph)FR ddPTM_A459_Selumetinib_30min_R1 2 ALYDYAGQEADELSFR 16 0 A0A0C4DGG1;Q9UKS6 A0A0C4DGG1 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 1 ALYDYAGQEADELS(1)FR;ALYDYAGQEADELS(1)FR 277.34 2.0874999999999995e-62 12015900.0 2318.16 2771.5 2648.0 2888.6000000000004 3079.2 2230.11 2150.05 2651.3 1467.67 2068.63 True False 2372.168617645854 2447.0114915646063 2288.416144422831 2384.1602357375637 2800.6869036769135 2207.6771181778713 1987.8699974848153 2580.9789113638712 2490.5287956243847 2334.1588106625436 1.0162841563348988 1.0483483301935355 0.9804029331548659 1.0214216037257668 1.1998699021177344 0.945812730519064 0.8516429937860847 1.1057426339518297 1.0669920076763997 1.0 11.188687006616037 -7.37282367337998 0.004571433181309118 0.4991858597957387 1.5455377521142093 0.0032307179355237636 0.08840913861804182 102863.45883270638 314.47854912792934 35769.66978269651 36200.188286182696 4.2381500300081024e-08 7.37282367337998 1.0463518923184707 ALYEAGER ddPTM_A459_Selumetinib_30min_R2 1 ALYEAGER 8 0 P04083 P04083 ANXA1 Annexin A1 0 138.83 0.033844 33443000.0 126150.0 136790.0 132240.0 114570.0 127880.0 82967.0 109670.0 96608.0 93517.0 121650.0 False True 119139.0880184616 147281.35315082545 123731.82237202584 98965.36835572631 111814.57113829484 94394.9511505612 114769.87230698233 96889.11328568464 112223.01308329847 118137.64841534176 1.0084768879062078 1.2466927785207125 1.0473530160090574 0.837712360819892 0.9464770345282598 0.7990251407298433 0.9714927785212113 0.8201374801794539 0.9499343739156807 1.0 16.85010927428229 -5.586056659418365 4.9956284046719945 0.8972909637347385 1.1326778570183147 0.5521788238191919 0.08319132021970718 0.11927849663613029 5.858358817808548 0.020778473255133167 0.037353299822213845 2.5938409394303097e-06 5.586056659418365 0.2353868932835762 ALYEAGERR ddPTM_A459_Selumetinib_30min_R1 1 ALYEAGERR 9 1 P04083 P04083 ANXA1 Annexin A1 0 138.06 0.0033813000000000003 20573000.0 1737.1 1794.8 3639.3 3465.3 3307.7 2359.4 2334.5 2457.9 1504.0 1851.5 False True 1777.571050191794 1584.6639816201177 3145.103049243963 2860.1504067373044 3008.519119021867 2335.666578163799 2158.4067854832665 2392.708507615606 2552.178152186168 2089.158060137239 0.8508552244606249 0.758517994333095 1.5054404495547637 1.3690445262669202 1.4400629499637927 1.1179941923639645 1.033146714299577 1.145297980689133 1.2216299957785448 1.0 11.028705931662499 -5.2414164707073665 24.896601447974824 1.235835603138889 0.8046865019966571 0.5298383560452868 0.15980926730744957 633.6065575623867 787827.1372912194 0.043833907563388674 0.11565515911323232 5.735661718148504e-06 5.2414164707073665 -0.4311491011422319 ALYEAGERR ddPTM_A459_Selumetinib_30min_R2 4 ALYEAGERR 9 1 P04083 P04083 ANXA1 Annexin A1 0 ;;; 138.06 0.0033813000000000003 29045900.0 57419.7 69678.4 65524.2 72184.9 67797.1 48349.600000000006 44492.6 42130.8 30099.300000000003 72516.2 False True 54228.54294327111 75022.50922863142 61308.4443093548 62353.19209410189 59279.8221842359 55009.31852603049 46561.59406041436 42253.393652870574 36120.00104470976 70422.46888628509 0.7700460350351651 1.065320634381255 0.8705807291186115 0.8854161616342493 0.8417742678115728 0.7811330587522708 0.6611752583624958 0.5999987549584406 0.512904497895901 1.0 16.103748185954743 -6.876143027607388 1.6429223506595034 0.6592881932162865 0.9071007150710514 0.29653745325793135 0.1371398887639809 0.3821718778994582 2.1230761163883574 0.059533976292900345 0.049483062869792475 1.3300163272612678e-07 6.876143027607388 0.24781252185476488 ALYESVFGSGEICGPT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 ALYESVFGSGEICGPTSPK 19 0 A0A2U3U043 A0A2U3U043 1 ALYESVFGSGEICGPT(0.866)S(0.134)PK 118.71 0.0024537 0.0 12853.0 8464.1 9477.3 11634.0 8895.7 8693.9 8198.2 9251.7 7507.4 8005.5 True False 12138.68171463564 9113.269253628945 8867.540836104037 10049.429130230586 7778.14263743298 9891.40580963351 8579.432544425117 9278.62091529861 9009.089774282254 7774.3604142130425 1.5613736780769476 1.1722210919072027 1.1406135506520187 1.2926374125720073 1.000486499598478 1.2723111976581505 1.1035547732955944 1.1934899362699325 1.1588206996181816 1.0 12.924508276278605 -4.761439120385195 5.788438737209125 1.15533131296894 1.5782654273142511 0.6435022626981192 0.09219986434171852 0.08259799443624584 9.813963405843387 0.02088503937958184 0.1392890593298024 1.732051813611034e-05 4.761439120385195 0.42293411434531114 AMADELS(ph)EK ddPTM_A459_Selumetinib_30min_R1 4 AMADELSEK 9 0 Q03135;E9PCT5 Q03135 CAV1 Caveolin-1;Caveolin 1 AMADELS(1)EK;AMADELS(1)EK;AMADELS(1)EK;AMADELS(1)EK 143.4 0.0020367 196343000.0 16063.9 13228.0 17508.5 9788.3 15501.2 13960.6 14947.5 19120.0 9316.9 16282.5 True False 16438.157615091797 11679.259610469644 15130.941867306328 8078.957154147334 14099.119196959135 13820.169039210616 13819.998040698714 18612.875489487124 15810.098820547415 18372.51747998087 0.894714490434052 0.6356918491543493 0.8235638846877332 0.4397305466140042 0.7674026824207335 0.752219670182347 0.7522103628834378 1.0130824754837302 0.8605298015241772 1.0 14.165261703714531 -7.668289887640425 5.238291956999551 0.951682086479386 0.712943084596239 0.442279773563938 0.12056809612797777 0.18837998044672738 8.275747977615845 0.057644495511853425 0.032176459784315235 2.1463972950767872e-08 7.668289887640425 -0.238739001883147 AMADELS(ph)EK ddPTM_A459_Selumetinib_30min_R2 2 AMADELSEK 9 0 Q03135;E9PCT5 Q03135 CAV1 Caveolin-1;Caveolin 1 AMADELS(1)EK;AMADELS(1)EK 121.61 0.0062081 174789000.0 870890.0 318980.0 526370.0 615390.0 326170.0 252690.0 1109540.0 598850.0 435420.0 404170.0 True False 822489.420248893 343444.7403176428 492503.92726832326 531572.8203930365 285193.6086032032 287495.7538085661 1161135.8085118013 600592.554355045 522516.16665130015 392500.5619402276 2.0955114463610545 0.8750171939115458 1.2547852793732428 1.3543237180740335 0.7266068797288353 0.7324722094343084 2.9583035569987954 1.5301699222700906 1.3312494740603 1.0 18.582335193938654 AMGDS(ph)DDEYDRR ddPTM_A459_Selumetinib_30min_R1 2 AMGDSDDEYDRR 12 1 C9JUL9 C9JUL9 SRRT 1 AMGDS(1)DDEYDRR;AMGDS(0.999)DDEY(0.001)DRR 112.64 0.011296 11500800.0 3472.3 4210.1 4284.7 4589.5 3900.4 3590.9 3654.4 3461.5 1945.09 2676.2 True False 3553.1978340803457 3717.17953477761 3702.8612741723946 3788.0299805849 3547.609508671552 3554.7788062763343 3378.74566582568 3369.689775463373 3300.6756662472044 3019.716338395507 1.1766660957195396 1.2309697727279552 1.2262281814655045 1.2544323890361264 1.1748154830186914 1.177189645622518 1.1188950507917375 1.1158961299172294 1.0930416292018283 1.0 11.560197318844677 -7.929996247439997 0.5295454266065398 1.0034923388092574 1.2282446062944161 0.8888767927738984 0.024210991443202243 0.25783961708669884 0.16977337404304926 0.025581512597245937 0.015234998527621857 1.1749077067899517e-08 7.929996247439997 0.22475226748515875 AMGDS(ph)DDEYDRR ddPTM_A459_Selumetinib_30min_R2 2 AMGDSDDEYDRR 12 1 C9JUL9 C9JUL9 SRRT 1 AMGDS(0.982)DDEY(0.018)DRR;AMGDS(1)DDEYDRR 125.03 0.0015064 19504400.0 48813.0 40573.0 48926.0 52212.0 65491.0 46789.0 47274.0 35319.0 39034.0 47124.0 True False 46100.16887392121 43684.81863724282 45778.154426601046 45100.63552927619 57263.43508303147 53233.760041746784 49472.33467165388 35421.77244262478 46841.89070108607 45763.4076771439 1.007358743893224 0.9545796708460761 1.0003222388848572 0.9855174214179263 1.2512930743055473 1.1632385511434256 1.0810456909301003 0.7740195549361559 1.023566492940184 1.0 15.481906862956686 -7.697569962059634 24.999951426230826 0.9240879144870507 1.0648087070401795 0.24706862776514038 0.1043093411530114 84.5300622851476 33086.336580715666 0.052733592209974804 0.03044573642979863 2.0064578364745747e-08 7.697569962059634 0.14072079255312875 AMKPPGGESSNLFGS(ph)PEEATPSSRPNR ddPTM_A459_Selumetinib_30min_R1 1 AMKPPGGESSNLFGSPEEATPSSRPNR 27 2 A6NGP5;Q9H910;Q9H910-3;H3BMV3;H3BMM8;B4E1P3 A6NGP5 HN1L Hematological and neurological expressed 1-like protein 1 AMKPPGGESSNLFGS(0.994)PEEAT(0.004)PS(0.001)S(0.001)RPNR 98.376 2.0081e-06 40592000.0 1258.3 1912.3 1910.8 2307.4 1667.7 1499.5 1802.6 1526.4 775.72 1320.9 True False 1287.6159417744136 1688.407026995849 1651.3238552730925 1904.45590526236 1516.8568294563497 1484.4163914370663 1666.628430718413 1485.9149135540345 1316.340183652829 1490.4503816555646 0.8639106391077265 1.1328166625180758 1.1079361484270498 1.2777720940612096 1.0177170928504533 0.9959515658536745 1.1182045717396867 0.9969569814887147 0.8831828283949062 1.0 10.541532632261555 -7.960356317469622 5.065807449762105 0.9401637572764547 1.079288382895724 0.2090948272763321 0.10423266770452631 0.2727135741734159 16.605801799816067 0.06265564451665086 0.02800182497706186 1.0955789581293373e-08 7.960356317469622 0.1391246256192693 AMKPPGGESSNLFGS(ph)PEEATPSSRPNR ddPTM_A459_Selumetinib_30min_R2 5 AMKPPGGESSNLFGSPEEATPSSRPNR 27 2 A6NGP5;Q9H910;Q9H910-3;H3BMV3;H3BMM8;B4E1P3 A6NGP5 HN1L Hematological and neurological expressed 1-like protein 1 AMKPPGGES(0.009)S(0.007)NLFGS(0.937)PEEAT(0.028)PS(0.01)S(0.01)RPNR;AMKPPGGES(0.013)S(0.051)NLFGS(0.932)PEEAT(0.002)PSSRPNR;AMKPPGGESSNLFGS(0.991)PEEAT(0.003)PS(0.003)S(0.003)RPNR;AMKPPGGES(0.008)S(0.031)NLFGS(0.894)PEEAT(0.014)PS(0.014)S(0.039)RPNR;AMKPPGGESSNLFGS(0.992)PEEAT(0.004)PS(0.001)S(0.003)RPNR 80.314 4.0184e-05 85654000.0 123602.0 141999.0 146861.0 180167.0 150170.0 115741.0 126741.0 143280.0 113120.0 159240.0 True False 116732.69565800935 152889.86670125084 137412.12315016665 155627.94379458934 131304.30206316648 131683.27215781092 132634.70763252713 143696.9210787191 135747.16083688242 154642.32744479223 0.7548560448282393 0.9886676515253107 0.8885802834235225 1.006373522476561 0.849083845495293 0.8515344688201375 0.8576869594767197 0.9292211482656282 0.8778137465975773 1.0 17.238575730547844 -10.769019786081849 3.700139315919257 1.0001713715787348 0.8936059085721428 0.18580701875640704 0.0689857087083421 95796837.29933272 197440590.01562956 199670.18675853783 0.01656933702963713 1.702080961288581e-11 10.769019786081849 -0.10656546300659198 AMKPPGGESSNLFGSPEEAT(ph)PSSRPNR ddPTM_A459_Selumetinib_30min_R1 1 AMKPPGGESSNLFGSPEEATPSSRPNR 27 2 A6NGP5;Q9H910;Q9H910-3;H3BMV3;H3BMM8;B4E1P3 A6NGP5 HN1L Hematological and neurological expressed 1-like protein 1 AMKPPGGESSNLFGS(0.098)PEEAT(0.301)PS(0.301)S(0.301)RPNR 107.07 6.3139e-09 28190000.0 1062.6 1388.0 1644.3 1718.3 1740.2 1186.0 1436.4 1605.4 983.31 1041.3 True False 1087.3565125403265 1225.4923147363058 1421.0130914933773 1418.2311614857895 1582.799217257263 1174.0699168018411 1328.051191547725 1562.8195769258698 1668.6052518791105 1174.9609981209326 0.9254405161356775 1.0430068033715043 1.209412987976576 1.207045309379553 1.3471078782943176 0.9992416077465409 1.1302938511760163 1.3301033646437828 1.4201367147910808 1.0 10.198397153153309 -5.051809515714749 2.272715061988323 1.2138829442892918 0.916881103672039 0.32723564105088054 0.1315652433068076 0.4439504394386022 3.890953149498685 0.036493274016198604 0.20972887080388605 8.875452095783411e-06 5.051809515714749 -0.29700184061725277 AMLDS(ph)GIYPPGSPGK ddPTM_A459_Selumetinib_30min_R1 1 AMLDSGIYPPGSPGK 15 0 O95295 O95295 SNAPIN SNARE-associated protein Snapin 1 AMLDS(1)GIYPPGSPGK 189.09 2.5774e-05 103520000.0 5684.8 6242.8 6799.8 6650.7 5295.8 5293.1 5457.7 5530.8 3253.9 4567.7 True False 5817.244779304766 5511.890073801015 5876.42450862778 5489.280094100881 4816.795825049429 5239.856219750277 5046.021294980524 5384.105217429673 5521.63064454692 5154.008788165739 1.1286835196443399 1.0694374612742255 1.1401657913585246 1.0650505887193997 0.9345726837155199 1.0166564387281711 0.9790478639785852 1.0446441670398903 1.071327363124659 1.0 12.331479281819325 -6.0058490079828815 21.85766820087591 1.0081234978232814 1.1074596071472318 0.6043481628619671 0.03832523637360011 36.06002120180873 134762.87090913163 0.01112937171952021 0.0158554482637675 9.866224469763273e-07 6.0058490079828815 0.09933610932395043 AMLDS(ph)GIYPPGSPGK ddPTM_A459_Selumetinib_30min_R2 1 AMLDSGIYPPGSPGK 15 0 O95295 O95295 SNAPIN SNARE-associated protein Snapin 1 AMLDS(1)GIYPPGSPGK 157.23 0.00018865 0.0 12393.0 8761.3 10794.0 12967.0 11933.0 12374.0 9641.3 10401.0 7583.5 7913.4 True False 11704.246673109741 9433.263537980327 10099.525791618604 11200.872230677325 10433.869857626472 14078.40618001185 10089.63955387352 10431.265188021755 9100.411900693909 7684.919580517579 1.5230148540242059 1.227503220969945 1.3142005828170815 1.4575132652101153 1.3577070974272645 1.831952310301687 1.3129141363368677 1.3573681648493203 1.184190908615988 1.0 12.907814447454447 -9.93412282087774 8.246452430806817 1.0000000002627893 1.3987721293979625 0.32025659606644663 0.17315731306748547 0.0 0.0 0.1702988272259356 0.04130353250419678 1.1637968546892557e-10 9.93412282087774 0.3987721291351731 AMLDSGIYPPGS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 3 AMLDSGIYPPGSPGK 15 0 O95295 O95295 SNAPIN SNARE-associated protein Snapin 1 AMLDS(0.211)GIY(0.211)PPGS(0.578)PGK;AMLDS(0.061)GIY(0.005)PPGS(0.934)PGK;AMLDS(0.019)GIY(0.001)PPGS(0.981)PGK 135.47 0.00040962 133201100.0 12868.300000000001 14303.8 17054.2 16727.1 13731.2 12927.099999999999 13287.6 13448.0 8099.099999999999 11937.8 True False 13168.106352646988 12629.104446343792 14738.333312015056 13806.02599155499 12489.215384440262 12797.065110867681 12285.305634091861 13091.315354739687 13743.581165140293 13470.132914019088 0.9775780563339679 0.9375634618423109 1.0941490634198632 1.0249361368354666 0.9271783332918762 0.9500325789323942 0.9120404165652951 0.9718772218732047 1.0203003380045799 1.0 13.717476465943589 -6.249731771582304 24.893284203573597 0.9589118435609898 1.0095994784746585 0.17342934286280032 0.04744057187061824 1259.25625074636 2677491.603076094 0.01484289022931427 0.018992246373373833 5.62688745015575e-07 6.249731771582304 0.05068763491366868 AMLDSGIYPPGS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 5 AMLDSGIYPPGSPGK 15 0 O95295 O95295 SNAPIN SNARE-associated protein Snapin 1 AMLDS(0.002)GIYPPGS(0.998)PGK;AMLDS(0.009)GIYPPGS(0.991)PGK;AMLDSGIYPPGS(1)PGK;AMLDSGIYPPGS(1)PGK;AMLDS(0.081)GIY(0.008)PPGS(0.911)PGK 216.26 3.6385e-09 92373900.0 581286.0 500804.0 508026.0 554384.0 529744.0 438945.0 480612.0 469406.0 347022.0 450467.0 True False 548980.451192227 539214.0564613357 475340.16025688587 478875.94283425884 463192.82274855254 499405.6894040172 502961.41031461087 470771.89374565304 416436.096604813 437460.8472561741 1.2549247655773588 1.232599579695816 1.086589035883547 1.0946715479518843 1.0588212080092965 1.1416008827678437 1.1497289722480697 1.0761463493211136 0.9519391260195472 1.0 18.738794375960055 -1.5228787452803376 0.2862051181616337 1.0304851879274768 2.8309952169731925 0.6301881930017094 0.05437905366753895 39.89815871454307 0.5648882584577806 0.06440955655703128 36.19203967422462 0.029999999999999995 1.5228787452803376 1.8005100290457157 AMLPGS(ph)PLFTR ddPTM_A459_Selumetinib_30min_R2 2 AMLPGSPLFTR 11 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 AMLPGS(1)PLFTR;AMLPGS(1)PLFTR 160.72 0.00060296 14160800.0 102430.0 77870.0 87147.0 106501.0 102957.0 76253.0 83521.0 74212.0 59748.0 65602.0 True False 96737.35065977805 83842.37860848592 81540.05689847928 91995.38007552775 90022.62121274181 86756.15859418479 87404.89199372171 74427.9446335421 71699.26949860364 63707.89980553424 1.5184514158379865 1.3160436753434246 1.2799049591554104 1.4440184083346004 1.413052721680234 1.3617802322632582 1.37196316721351 1.168268689765796 1.1254376571424067 1.0 15.959184657896364 -8.043366617427703 1.3430801311355887 1.0177973856298845 1.3886932458075911 0.8072037746195218 0.06640580734080899 0.18445429031015023 0.6004283613026866 0.06096373040938517 0.020349042582230373 9.049683332099827e-09 8.043366617427703 0.3708958601777066 AMLSEQNRAS(ph)PLPSGLLTPPQSGK ddPTM_A459_Selumetinib_30min_R2 1 AMLSEQNRASPLPSGLLTPPQSGK 24 1 I3L413;C9J2U0;P24864-2;P24864-3;P24864 I3L413 CCNE1 G1/S-specific cyclin-E1 1 AMLS(0.189)EQNRAS(0.742)PLPS(0.006)GLLT(0.063)PPQSGK 69.578 0.00093688 7513600.0 57730.0 49981.0 57397.0 61647.0 57818.0 48213.0 49891.0 41412.0 36088.0 57576.0 True False 54521.59771150046 53814.38198575489 53704.139509128516 53250.572252993385 50554.385940521825 54853.9031159618 52211.03035714104 41532.50206387434 43306.608382968545 55913.63127958657 0.9751038604320745 0.9624555006392852 0.9604838441021678 0.9523719178016357 0.9041513631574606 0.9810470516871678 0.9337799953658652 0.74279743800216 0.7745268442040769 1.0 15.770912422583724 -7.633595747138325 7.163945944253795 0.8197874202589638 0.9541340781419889 0.37315532668039564 0.0665430466445556 0.19157091996184092 11.34811640921276 0.029950898280116642 0.017146707827480047 2.3248998681485802e-08 7.633595747138325 0.13434665788302513 AMLSGPDMVS(ph)T(ph)MLPRLK ddPTM_A459_Selumetinib_30min_R1 1 AMLSGPDMVSTMLPRLK 17 1 R4GMY8 R4GMY8 TCEB1 2 AMLS(0.018)GPDMVS(0.991)T(0.991)MLPRLK 45.863 0.045601 0.0 455.25 867.98 708.37 847.58 848.95 910.2 790.34 694.69 291.5 644.38 True False 465.8564392377031 766.3564980870451 612.1772447978859 699.5660640470961 772.1626223942957 901.0442143954771 730.7240174936155 676.2645645288601 494.6542096823592 727.092449792727 0.6407114244832349 1.0540014523675925 0.8419524160543819 0.9621418352597694 1.0619868527233598 1.2392429802459628 1.004994643668661 0.9300943294372586 0.6803181766271548 1.0 9.505995004232808 -4.753690783818262 24.78771554653592 0.980144100848724 0.6407107412960754 0.3430352128175088 0.13860692876607122 312.59867913441326 999910.5943470224 0.03653117987760071 0.3813492896520344 1.7632310140274275e-05 4.753690783818262 -0.33943335955264864 AMS(ph)LNTLNVDAPR ddPTM_A459_Selumetinib_30min_R1 1 AMSLNTLNVDAPR 13 0 Q6P597;Q6P597-3;Q6P597-2 Q6P597 KLC3 Kinesin light chain 3 1 AMS(0.993)LNT(0.007)LNVDAPR 169.4 0.000255 6600200.0 752.31 810.8 771.24 848.33 899.32 697.13 652.65 732.36 287.6 635.3 True False 769.837359259564 715.8711590693061 666.5098441180754 700.1850906263398 817.9766647878419 690.1175051433956 603.4200850484705 712.9354337594557 488.036194527089 716.846943346037 1.0739215203543768 0.998638782956685 0.9297798509218684 0.9767567499947416 1.1410757517773042 0.9627124891153528 0.8417697677999123 0.9945434522349729 0.6808094797043777 1.0 9.485521306404294 -7.006465817891398 24.694041195915528 0.8821709685544161 1.0184740779399286 0.32395537291541954 0.0983849538996569 315.75994629677814 1205943.2116831294 0.034365709261784824 0.02924178891584449 9.852221838454558e-08 7.006465817891398 0.1363031093855125 AMS(ph)PVTITTFSR ddPTM_A459_Selumetinib_30min_R1 1 AMSPVTITTFSR 12 0 A0A075B6G6;Q7Z7B0-3;Q7Z7B0-2;Q7Z7B0 A0A075B6G6 FILIP1 Filamin-A-interacting protein 1 1 AMS(0.999)PVT(0.001)ITTFSR 161.25 0.0004803999999999999 39077000.0 1379.4 1517.8 1856.4 2101.0 1890.8 1311.4 1646.3 1569.0 811.45 1292.1 True False 1411.537336154834 1340.0952703939233 1604.3110764752814 1734.0997906545101 1719.7774738478522 1298.2085066559316 1522.1182655562652 1527.3850231697331 1376.9713840368784 1457.9536211198094 0.9681634008842308 0.9191617970430618 1.1003855357504853 1.1894066899896316 1.1795831149463754 0.8904319642615364 1.044010072410378 1.0476225039288942 0.9444548606280554 1.0 10.509729111566521 -8.247997747898513 23.05322102363489 0.9722274362151418 1.0446424890173514 0.0806424627157819 0.09444585166484375 705.3205851048767 1209681.620689215 0.0708112287423848 0.02634526033463814 5.6493990438832315e-09 8.247997747898513 0.0724150528022095 AMS(ph)PVTITTFSR ddPTM_A459_Selumetinib_30min_R2 2 AMSPVTITTFSR 12 0 A0A075B6G6;Q7Z7B0-3;Q7Z7B0-2;Q7Z7B0 A0A075B6G6 FILIP1 Filamin-A-interacting protein 1 1 AMS(0.999)PVT(0.001)ITTFSR;AMS(0.983)PVT(0.017)ITTFSR 155.88 0.00043015 37342000.0 64019.0 55862.0 67588.0 67750.0 67015.0 44366.0 46664.0 45854.0 39174.0 47688.0 True False 60461.080268362166 60146.43577535949 63239.461664250295 58522.33312473112 58595.976578298665 50477.01378555084 48833.96846296184 45987.42754846165 47009.89461301292 46311.12353169591 1.3055412103526673 1.298747065253006 1.3655350343847397 1.263677679611416 1.2652678689212722 1.0899544199354987 1.0544760035791243 0.9930104053076425 1.015088622949058 1.0 15.499071137539959 -6.8249188576964945 1.453216743808099 1.0054520771005113 1.317604873691486 0.9639963252784317 0.026481099340790806 0.06500694135735965 0.28531524364104066 0.011997369734028394 0.010287684248661477 1.4965152344801736e-07 6.8249188576964945 0.3121527965909747 AMS(ph)TTSISSPQPGK ddPTM_A459_Selumetinib_30min_R1 3 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMS(0.693)T(0.265)T(0.033)S(0.01)ISSPQPGK;AMS(0.977)T(0.023)T(0.001)SISSPQPGK;AMS(0.948)T(0.052)TSISSPQPGK 222.29 5.1651e-09 28400800.0 13788.899999999998 13333.699999999999 15333.400000000001 19524.2 13011.8 15495.599999999999 17000.8 17569.3 8146.200000000001 10313.7 True False 14110.154541471207 11772.584205331043 13251.208500337252 16114.664984624846 11834.884987419868 15339.728332879104 15718.415968577385 17103.305090870617 13823.506425092397 11637.563858945416 1.212466347123431 1.0116021143275482 1.138658284581741 1.3847111972870532 1.0169555356143354 1.3181219470678096 1.3506620594391112 1.4696636940663372 1.187835065194226 1.0 13.506501463873247 -6.805596879848891 24.999404715658244 1.2999485589896895 1.1571192181794838 0.09957429868402923 0.1517456134430526 240.29319647752345 136038.25578499088 0.05210163317432365 0.04594954379443465 1.5645992587281034e-07 6.805596879848891 -0.1428293408102057 AMS(ph)TTSISSPQPGK ddPTM_A459_Selumetinib_30min_R2 3 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMS(0.328)T(0.328)T(0.328)S(0.017)ISSPQPGK;AMS(0.81)T(0.187)T(0.003)S(0.001)ISSPQPGK;AMS(0.495)T(0.495)T(0.005)S(0.004)ISSPQPGK 178.67 7.1766e-05 85470500.0 455483.0 460310.0 531796.0 542791.0 401191.0 324045.0 269276.0 335048.0 350966.0 577145.0 True False 430169.0783029161 495614.2968700674 497580.8243357052 468861.9294332986 350789.79988695367 368679.2573623677 281797.8675602715 336022.9342098174 421169.0068093804 560481.3242472039 0.7674993968455357 0.8842654972237283 0.8877741377092593 0.8365344377228598 0.6258724148536224 0.6577904408457317 0.502778335993195 0.5995256570968497 0.7514416423688385 1.0 19.096306776343823 -6.236657044436497 8.972841681130403 0.6586122786436854 0.8502662109996254 0.23887942973766785 0.12790989962181096 0.39667931949733815 135.71890137843585 0.03653742021109412 0.046494546571086495 5.798864429247061e-07 6.236657044436497 0.19165393235593997 AMST(ph)TSISSPQPGK ddPTM_A459_Selumetinib_30min_R2 1 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMS(0.3)T(0.661)T(0.02)S(0.014)IS(0.004)SPQPGK 118.52 0.023909 6564600.0 34595.0 42181.0 44136.0 39198.0 29005.0 23749.0 21265.0 22532.0 30864.0 48219.0 True False 32672.348394757613 45416.14706670791 41296.337811643374 33859.16477967839 25361.13259201002 27020.209178042787 22253.864635798112 22597.564389626594 37037.66241221294 46826.79218199222 0.6977276655589947 0.9698752562464275 0.8818955108251971 0.7230724805595229 0.541594489185679 0.5770245604915409 0.47523786274550944 0.4825776726665626 0.790950237809717 1.0 15.515046590730929 -5.965306835342382 3.757248109579525 0.6075401073981066 0.8600364605751377 0.2207059885666106 0.16296133628471052 0.25938159300475944 7.8670681280625505 0.046053016370760404 0.06858444472557204 1.0831613744196154e-06 5.965306835342382 0.2524963531770311 AMSTSQS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 AMSTSQSPTR 10 0 Q15776 Q15776 ZKSCAN8 Zinc finger protein with KRAB and SCAN domains 8 1 AMST(0.003)S(0.012)QS(0.688)PT(0.298)R 89.561 0.03067 4723700.0 15446.0 14631.0 20078.0 13654.0 12483.0 11605.0 12463.0 10463.0 11186.0 16877.0 True False 14587.573155237062 15753.150653920095 18786.203339273525 11794.30164553622 10914.77394056408 13203.48341029882 13042.554194965996 10493.445597757101 13423.512562954054 16389.717158287873 0.8900442279969724 0.9611606168538496 1.1462188857709366 0.7196159355057652 0.665952550318707 0.8055955623140297 0.7957766487977922 0.6402456794350979 0.8190203914633217 1.0 14.000503337229263 -5.779112369729728 24.999906832964626 0.7602579111539383 0.9953432103851464 0.44702661645532993 0.1114515449522223 190.15136198116406 268984.25678261387 0.030346237456800026 0.04512117103197769 1.6629823132181704e-06 5.779112369729728 0.23508529923120813 AMSTTS(ph)ISSPQPGK ddPTM_A459_Selumetinib_30min_R1 1 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMS(0.018)T(0.064)T(0.064)S(0.852)IS(0.001)S(0.001)PQPGK 234.04 9.392799999999999e-14 21673000.0 2837.3 2477.8 2671.9 3289.3 2599.5 3029.5 3027.3 3515.7 1651.0 2032.4 True False 2903.4035695752573 2187.698024102032 2309.070655696136 2714.885502808128 2364.375683979001 2999.0259805659152 2798.9483237067884 3422.4522153969583 2801.6264157309597 2293.2783372524564 1.266049359300094 0.9539609686991075 1.0068863505084167 1.1838447425709315 1.0310024934922315 1.307746177971142 1.220500921427692 1.4923841383760459 1.2216687221175027 1.0 11.163195751401219 -6.765072873491283 24.994165700031047 1.2774865817031953 1.081662425125964 0.2303047097983526 0.1411962315077335 113.2555393129853 779059.0684793885 0.046889190069701873 0.042961013059187134 1.7176201507548657e-07 6.765072873491283 -0.19582415657723118 AMSTTSIS(ph)SPQPGK ddPTM_A459_Selumetinib_30min_R1 4 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMST(0.001)TS(0.001)IS(0.499)S(0.499)PQPGK;AMSTT(0.003)S(0.053)IS(0.733)S(0.212)PQPGK;AMST(0.002)T(0.009)S(0.021)IS(0.767)S(0.202)PQPGK;AMSTT(0.001)S(0.024)IS(0.702)S(0.272)PQPGK 163.71 0.00026602 64580300.0 18227.300000000003 19630.9 20631.7 21796.6 22237.1 15292.6 18461.6 16410.5 10163.099999999999 16978.100000000002 True False 18651.960625848198 17332.505101842187 17830.02846181592 17990.23298285582 20225.758231278873 15138.77032856984 17069.02664848057 15975.240231183498 17246.038416544703 19157.40451569865 0.9736162646961772 0.904741823854007 0.930712114326604 0.939074652211557 1.0557671429187996 0.7902307599217986 0.8909884757349699 0.8338937677122437 0.900228337424954 1.0 14.225614494591468 -6.769240759655741 24.999992492097224 0.873181665386131 0.9547924800423344 0.26788405393174375 0.06279977768607667 227.62419773768812 729431.0938602583 0.021111591815544114 0.01895835899597719 1.7012151449833675e-07 6.769240759655741 0.08161081465620346 AMSTTSIS(ph)SPQPGK ddPTM_A459_Selumetinib_30min_R2 4 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMSTTS(0.001)IS(0.739)S(0.259)PQPGK;AMSTTS(0.003)IS(0.936)S(0.062)PQPGK;AMSTT(0.001)S(0.021)IS(0.692)S(0.286)PQPGK;AMSTTS(0.029)IS(0.759)S(0.211)PQPGK 265.77 1.0653e-36 184955600.0 520398.0 418456.0 539666.0 567038.0 653993.0 449950.0 442066.0 443330.0 327958.0 437442.0 True False 491476.3624782503 450550.2296518891 504944.47710391367 489806.44620489085 571832.552568399 511926.52826057276 462622.9449371604 444620.01690276765 393558.7639121485 424811.9128491887 1.156926977828722 1.0605875589271379 1.1886306900323969 1.1529960233925352 1.346084079264989 1.2050663194144235 1.0890065248744445 1.0466279392230955 0.9264306202539679 1.0 18.69646469812941 -7.705596506565375 2.0397658515078447 0.9716888226443372 1.1837322602891462 0.6098229206645874 0.07044322552066334 0.24683730196676795 2.0287193204003855 0.05203756225706663 0.02267355769363183 1.969715459090437e-08 7.705596506565375 0.21204343764480904 AMSTTSISS(ph)PQPGK ddPTM_A459_Selumetinib_30min_R1 3 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMSTTSIS(0.018)S(0.982)PQPGK;AMSTTSIS(0.065)S(0.935)PQPGK;AMSTTSIS(0.068)S(0.932)PQPGK 283.66 6.6506e-55 130525000.0 23974.4 26375.6 27192.8 29071.4 29435.8 20351.1 23286.300000000003 21938.1 13243.5 21827.5 True False 24532.956873938263 23287.532490316225 23500.167119358455 23994.625727764647 26773.337087312597 20146.38641132036 21529.79564309231 21356.230323008225 22473.25223303026 24629.272242854775 0.9960893944422392 0.9455225579014904 0.9541559688665228 0.9742320232269857 1.0870535200275695 0.8179854529467492 0.8741547631127567 0.8671076478601151 0.9124610752374138 1.0 14.588086378594761 -6.7737676087976375 24.998997036503322 0.8847743416874387 0.985837289762847 0.4172529241502386 0.05660626142938672 216.4842265205475 438980.8286887633 0.019561028999666497 0.01737291807596908 1.6835747017778453e-07 6.7737676087976375 0.10106294807540828 AMSTTSISS(ph)PQPGK ddPTM_A459_Selumetinib_30min_R2 2 AMSTTSISSPQPGK 14 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 AMSTTS(0.002)IS(0.096)S(0.902)PQPGK;AMSTTSIS(0.061)S(0.938)PQPGK 284.91 4.0163e-55 163299000.0 333700.0 279755.0 314974.0 354540.0 408550.0 271459.0 266064.0 273212.0 204583.0 262566.0 True False 315154.2899069409 301211.30894589657 294708.9157577609 306251.0403843868 357224.2965166592 308850.0131905474 278436.5031958139 274007.00168731826 245505.31652662583 254985.0373516032 1.235971699281983 1.1812901340189275 1.1557890565609217 1.201054946459827 1.4009617984920288 1.2112475947546242 1.0919719293641261 1.0746003158980868 0.9628224427462948 1.0 17.960053065944543 -7.548047497040057 1.8854372775970674 1.0012624122348681 1.2315322719800226 0.6984926732400666 0.06596171672034852 0.2221594867452351 1.554009587579445 0.045300612071452175 0.022299252010166828 2.8310823547816042e-08 7.548047497040057 0.23026985974515446 AMT(ph)LSPQEEVAAGQMASSSR ddPTM_A459_Selumetinib_30min_R1 2 AMTLSPQEEVAAGQMASSSR 20 0 A0A494BZT8;Q9Y6A5 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 AMT(0.737)LS(0.263)PQEEVAAGQMASSSR;AMT(0.87)LS(0.13)PQEEVAAGQMASSSR 179.85 6.5123e-13 36892000.0 3980.0 4643.700000000001 5349.700000000001 5528.1 5450.8 4189.6 5695.9 4459.5 2553.4 3502.7999999999997 True False 4072.726256268116 4100.013445202437 4623.24012379865 4562.721110289006 4957.776102416899 4147.456427852441 5266.2536772046005 4341.219573502499 4332.933307042662 3952.418500161338 1.0304390226140947 1.0373429445882498 1.1697243405803126 1.1544124464812506 1.254365169633358 1.0493464767668559 1.3324129711946322 1.0983704213825762 1.096273916050588 1.0 11.94851999882693 -5.255764996016077 22.417950194876436 1.1554865997806005 1.0338908998078482 0.18163561819560614 0.09138808554626242 157.05419140669005 620453.4205422415 0.02217543251663386 0.05499617342424122 5.549259113907635e-06 5.255764996016077 -0.12159569997275232 AMT(ph)LSPQEEVAAGQMASSSR ddPTM_A459_Selumetinib_30min_R2 1 AMTLSPQEEVAAGQMASSSR 20 0 A0A494BZT8;Q9Y6A5 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 AMT(0.992)LS(0.008)PQEEVAAGQMASSSR 207.54 2.7215e-16 16646000.0 15743.0 15262.0 18986.0 19417.0 15964.0 16689.0 13804.0 13058.0 13144.0 18780.0 True False 14868.067084222257 16432.54632493531 17764.461430393803 16772.371103806705 13958.459600029235 18987.758262341817 14445.913352107082 13095.996618131734 15773.167274045061 18237.77260370009 0.8152348100450498 0.9010171736433135 0.9740477533308941 0.9196501934893034 0.7653598881475984 1.041122656529316 0.7920875901904976 0.718069958580074 0.8648625913257079 1.0 14.15464192211027 AMT(ph)RCPRAS(ph)SMSGSCGRR ddPTM_A459_Selumetinib_30min_R1 1 AMTRCPRASSMSGSCGRR 18 3 Q9Y250-7 Q9Y250-7 2 AMT(1)RCPRAS(0.447)S(0.447)MS(0.053)GS(0.053)CGRR 57.703 0.02893 16673000.0 2181.5 1834.2 2505.7 2541.3 2256.5 1785.5 2289.3 2177.7 1155.4 2006.5 True False 2232.3247055399215 1619.4510113035544 2165.4397028248814 2097.5096611091412 2052.3999734174317 1767.5394911042904 2116.6162578739973 2119.9403218334783 1960.6294129228056 2264.0538199650923 0.9859857066358696 0.7152882131258361 0.9564435631915625 0.9264398410553161 0.9065155409817405 0.7806967641482757 0.9348789499653466 0.9363471411939156 0.8659818046874146 1.0 11.144692538270863 -14.52287714816839 0.24694728018717496 1.6726451988072475 0.8773922959643714 0.14390876503772276 0.07924834688139837 341.1848597702248 3.3834059048773266 115.53136789902189 0.11378523708028047 3.000011032478768e-15 14.52287714816839 -0.7952529028428761 AMTLS(ph)PQEEVAAGQMASSSR ddPTM_A459_Selumetinib_30min_R1 1 AMTLSPQEEVAAGQMASSSR 20 0 A0A494BZT8;Q9Y6A5 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 AMT(0.003)LS(0.997)PQEEVAAGQMASSSR 286.67 1.3387999999999995e-73 31968000.0 3339.4 3277.4 3625.6 3988.6 4239.8 2844.0 3229.5 2935.8 1791.5 2959.5 True False 3417.2015226587296 2893.680484378076 3133.2634339952483 3292.0658852948977 3856.3108385974892 2815.3919421453943 2985.8962149146323 2857.933047177629 3040.044654016967 3339.38065297119 1.023303982916203 0.8665320863626147 0.9382768122608154 0.9858312745406265 1.1547982213906534 0.8430880557568121 0.8941467071919317 0.8558272758257742 0.9103618215288242 1.0 11.705364838935584 AMTLS(ph)PQEEVAAGQMASSSR ddPTM_A459_Selumetinib_30min_R2 5 AMTLSPQEEVAAGQMASSSR 20 0 A0A494BZT8;Q9Y6A5 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 AMT(0.013)LS(0.603)PQEEVAAGQMAS(0.37)S(0.013)S(0.001)R;AMT(0.003)LS(0.997)PQEEVAAGQMASSSR;AMT(0.211)LS(0.789)PQEEVAAGQMASSSR;AMT(0.016)LS(0.984)PQEEVAAGQMASSSR;AMT(0.205)LS(0.795)PQEEVAAGQMASSSR 299.6 1.739799999999999e-100 37098800.0 106088.0 111690.0 125407.0 132674.0 143334.0 100415.0 98869.0 107463.0 89093.0 119998.0 True False 100192.05366391229 120256.26386004637 117338.45015281766 114603.57232458444 125327.10149778199 114246.2547733868 103466.6044052068 107775.69953854254 106914.08946641057 116533.34594775298 0.8597715344827804 1.0319472326312722 1.0069087881972054 0.9834401594884803 1.0754612808763908 0.9803739336945531 0.8878712231569789 0.9248485801382818 0.9174549018299436 1.0 16.830383314722013 -7.072322985093342 7.62643523322935 0.9269940916437841 0.9974409429715247 0.18551914008439163 0.05786000633690429 0.4250874071596026 40.14040752160453 0.021628405561024418 0.01678428385088322 8.465975647912425e-08 7.072322985093342 0.07044685132774064 ANAS(ph)PQKPLDLK ddPTM_A459_Selumetinib_30min_R1 2 ANASPQKPLDLK 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 ANAS(1)PQKPLDLK;ANAS(1)PQKPLDLK 80.387 0.022129 478370000.0 13938.6 16308.9 17541.699999999997 18625.8 15547.8 14178.3 14684.400000000001 14799.0 9280.3 13402.7 True False 14263.342260205709 14399.446406198083 15159.63348966087 15373.153679568199 14141.50423518704 14035.679174866396 13576.743885521744 14406.482446073207 15747.991293705647 15123.067098353438 0.9431514234145444 0.952151194764312 1.0024179216470852 1.0165367633158215 0.9350949872282674 0.9280973947668701 0.8977506875572844 0.9526164469403001 1.041322582997747 1.0 13.884463140725495 -8.250791974158874 24.42627966396542 1.0206612906969716 0.953849976912148 0.3872999124927988 0.03379822335636384 530.6469309577358 1217370.419825243 0.02638620522976525 0.009720230327467001 5.613167808156975e-09 8.250791974158874 -0.06681131378482363 ANAS(ph)PQKPLDLK ddPTM_A459_Selumetinib_30min_R2 2 ANASPQKPLDLK 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 ANAS(1)PQKPLDLK;ANAS(1)PQKPLDLK 82.515 0.019901 382803000.0 3120620.0 2909290.0 2920090.0 3309880.0 3113340.0 2349657.0 2671733.0 2695470.0 2072719.0 2788050.0 True False 2947188.43323164 3132423.188158236 2732214.5885536056 2859068.6341385306 2722214.395587258 2673300.92368742 2795973.8784385053 2703313.3714409187 2487320.716607687 2707551.752276146 1.0885067776651138 1.1569208919182856 1.0091089066928183 1.0559608442331747 1.0054154618831517 0.9873498895967796 1.032657594111738 0.9984346076370787 0.9186604520178356 1.0 21.368557483164643 -5.381375992173307 0.613330544438329 0.9817474348789418 1.1635996846437406 0.5998617016741792 0.03855272222524993 1.3129027336442456 0.6120261844515946 0.02110216447551904 0.15302388303058817 4.1555069005418905e-06 5.381375992173307 0.18185224976479886 ANASNS(ph)PSSLR ddPTM_A459_Selumetinib_30min_R1 1 ANASNSPSSLR 11 0 Q5T5X7 Q5T5X7 BEND3 BEN domain-containing protein 3 1 ANAS(0.045)NS(0.938)PS(0.017)SLR 120.6 0.0035551000000000007 0.0 1657.6 2262.8 2194.7 2430.8 2168.8 1845.5 2223.1 2019.0 1227.8 1941.8 True False 1696.218854871866 1997.870324052819 1896.6717946241654 2006.306411767246 1972.6324229327406 1826.9359455799315 2055.4097771719216 1965.449561363728 2083.4869250360207 2191.048944733725 0.774158358693354 0.9118328136186922 0.8656455617675237 0.9156830643101264 0.9003141749407482 0.8338179527988392 0.9380939581985069 0.8970358996716006 0.9509084359086392 1.0 11.097405996984714 -7.324730296664846 0.020508557563187185 1.8131452657811362 5.846626140101235e-08 0.5582173704167779 0.03977934548915334 283.93541822894997 3.7106113159665735 158.7812128071052 168.29713191936582 4.734451841898634e-08 7.324730296664846 -1.8131452073148748 ANASNS(ph)PSSLR ddPTM_A459_Selumetinib_30min_R2 1 ANASNSPSSLR 11 0 Q5T5X7 Q5T5X7 BEND3 BEN domain-containing protein 3 1 ANAS(0.019)NS(0.429)PS(0.429)S(0.122)LR 92.151 0.025412 2609300.0 23992.0 20732.0 25446.0 27001.0 29931.0 22777.0 21053.0 24007.0 21675.0 24538.0 True False 22658.620687585633 22322.077736113133 23808.832063510003 23323.417220676984 26170.80019346498 25914.32500098028 22032.006215728066 24076.856395427207 26010.605650100948 23829.524182619418 0.9508633287823762 0.9367403883118331 0.9991316604162618 0.978761348398573 1.0982510600254967 1.087488142960129 0.9245676097803744 1.0103792342185407 1.091528536229538 1.0 14.54046252426988 -5.61872693412076 1.792845996966676 1.0312503683349512 0.9444122863472764 0.3003783827631107 0.051389188171777345 0.4902151849557175 3.1366050494205493 0.01654946477713885 0.04070753633158986 2.4058750363299733e-06 5.61872693412076 -0.08683808198767484 ANASNSPS(ph)SLR ddPTM_A459_Selumetinib_30min_R2 1 ANASNSPSSLR 11 0 Q5T5X7 Q5T5X7 BEND3 BEN domain-containing protein 3 1 ANAS(0.013)NS(0.051)PS(0.836)S(0.1)LR 104.41 0.012326 5063200.0 18454.0 17918.0 21189.0 17829.0 19757.0 16769.0 17763.0 22576.0 13914.0 21869.0 True False 17428.40055721512 19292.25298454927 19825.72280883885 15400.659443259503 17274.949030179014 19078.777536174137 18589.014696716764 22641.69242234201 16697.188789642663 21237.585147514208 0.8206394670655416 0.908401442562662 0.9335205801945609 0.7251605743444001 0.8134139974101995 0.8983496665771931 0.8752885305744165 1.0661142622890036 0.7862093865034847 1.0 14.374332111144948 -7.296206014306141 2.3376056225348782 0.9444577354020757 0.8456783832336509 0.20128829814450866 0.08652095974069975 0.5104988496506709 5.468981530882883 0.04184446529196038 0.026749758237533602 5.0558477315144436e-08 7.296206014306141 -0.09877935216842482 ANASNSPSS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 ANASNSPSSLR 11 0 Q5T5X7 Q5T5X7 BEND3 BEN domain-containing protein 3 1 ANAS(0.005)NS(0.11)PS(0.304)S(0.581)LR 83.137 0.03866 2402800.0 11589.0 12401.0 14555.0 12799.0 14750.0 13290.0 11687.0 11314.0 9460.1 16264.0 True False 10944.929774442724 13352.11682450025 13618.54714628579 11055.754120493495 12896.973133326936 15120.576865391755 12230.468657351172 11346.921866866476 11352.384337278898 15794.416061053136 0.6929619766970315 0.8453694503733341 0.8622380905785595 0.6999786556057281 0.8165527034031415 0.9573368719010147 0.7743539621898292 0.7184135091164547 0.7187593573194719 1.0 13.947126979413865 -4.751379242611677 24.12257714322017 0.8127462988089987 0.6929615892144052 0.13424635739498925 0.0956144966689951 597.3445778121628 1432178.102811074 0.02377184542647889 0.3042830035517142 1.7726408667875185e-05 4.751379242611677 -0.11978470959459353 ANDDIIVNWVNR ddPTM_A459_Selumetinib_30min_R2 1 ANDDIIVNWVNR 12 0 A0A0A0MSQ0;P13797-3;P13797-2;P13797 A0A0A0MSQ0 PLS3 Plastin-3 0 128.08 0.030847000000000006 0.0 12948.0 11481.0 12648.0 11014.0 12912.0 11483.0 12708.0 10069.0 6680.7 13328.0 False True 12228.401994950758 12361.5557827665 11834.24145010117 9513.874199790247 11289.879125255427 13064.67901770454 13298.947180424286 10098.299122987315 8017.026674354298 12943.18600969727 0.9447752652081965 0.9550628240608608 0.9143221337648042 0.7350488660722545 0.8722643031473738 1.0093866384919636 1.0274863677660564 0.7802019622851348 0.619401333516168 1.0 13.659905164934681 -7.86042790769359 10.226205749434005 0.7735242582832705 0.9176664232866132 0.18104347490654427 0.11536318118793012 0.5152522682575122 49.13855166165318 0.06412699868497565 0.030777732800372524 1.3790248502611305e-08 7.86042790769359 0.14414216500334265 ANEAGGQVGPEAPRPPET(ph)SPEMR ddPTM_A459_Selumetinib_30min_R1 1 ANEAGGQVGPEAPRPPETSPEMR 23 1 Q8N3D4;E9PIH6 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 ANEAGGQVGPEAPRPPET(0.5)S(0.5)PEMR 58.324 0.019995 45095000.0 649.49 748.22 912.91 1016.8 919.07 742.01 1031.3 816.1 348.53 598.0 True False 664.6218533124569 660.618054561959 788.9418362556825 839.2349676999078 835.9402807749874 734.5460530911753 953.5082106956066 794.4543769336005 591.4299543759606 674.7591250132697 0.9849764585241979 0.9790427873783365 1.1692199586632746 1.243754899473799 1.2388721393853666 1.08860484558357 1.4131090271315043 1.1773896009453402 0.8765053075263408 1.0 9.398228771688974 -5.2624705329583765 20.488821413927045 1.1708606804807529 0.9820094923427657 0.1817108107479949 0.13830791448362026 10.324463773974813 205255.33678728074 0.03584042011936019 0.08234124471934913 5.4642362366957205e-06 5.2624705329583765 -0.18885118813798718 ANEAGGQVGPEAPRPPET(ph)SPEMR ddPTM_A459_Selumetinib_30min_R2 4 ANEAGGQVGPEAPRPPETSPEMR 23 1 Q8N3D4;E9PIH6 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 ANEAGGQVGPEAPRPPET(0.5)S(0.5)PEMR;ANEAGGQVGPEAPRPPET(0.514)S(0.486)PEMR;ANEAGGQVGPEAPRPPET(0.5)S(0.5)PEMR;ANEAGGQVGPEAPRPPET(0.5)S(0.5)PEMR 91.335 0.000207 89976100.0 150915.0 108470.0 143562.0 129382.0 140873.0 82296.3 106554.0 106791.0 95685.0 98917.0 True False 142527.74846061112 116789.30021397816 134325.3772184869 111759.94840360104 123175.27431940098 93631.86831356952 111508.97213274536 107101.74412979819 114824.67366227935 96061.0091927689 1.4837211232561156 1.215782565636106 1.3983340207152266 1.1634267570448749 1.2822608814385965 0.9747125196829366 1.1608140812780396 1.1149346132193287 1.195330703135304 1.0 16.551663344795138 -1.52287874528402 0.2521056295223588 1.0528820838548183 3.5211156596042184 0.5799557185779922 0.0978029679735241 36.62152290791239 0.4996136909316379 0.12027406455804614 38.4358679957395 0.029999999999745626 1.52287874528402 2.4682335757494 ANEAGGQVGPEAPRPPETS(ph)PEMR ddPTM_A459_Selumetinib_30min_R1 3 ANEAGGQVGPEAPRPPETSPEMR 23 1 Q8N3D4;E9PIH6 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 ANEAGGQVGPEAPRPPET(0.288)S(0.712)PEMR;ANEAGGQVGPEAPRPPET(0.284)S(0.716)PEMR;ANEAGGQVGPEAPRPPET(0.392)S(0.608)PEMR 83.179 0.00020643 76382000.0 3963.7000000000003 4506.200000000001 5221.8 4767.3 5191.7 4415.400000000001 4826.799999999999 4453.7 2100.8 4047.7 True False 4056.046497982396 3978.6120091244575 4512.708241294239 3934.78054830426 4722.111651669079 4370.985084862435 4462.710589921026 4335.573408343553 3564.9041636387647 4567.261722936811 0.8880696452346732 0.871115397031847 0.9880555385366677 0.8615185174398421 1.033904325638842 0.9570253140763373 0.9771085741614658 0.9492719426544535 0.780534241279802 1.0 12.15711374912418 -5.238537852740249 24.102538919186017 0.9436101462534462 0.8795924954932208 0.11932139070459091 0.06936780735401518 1086.9579574360134 1143953.0056409803 0.017254108591254237 0.04556099412129332 5.773805465200287e-06 5.238537852740249 -0.06401765076022536 ANEAGGQVGPEAPRPPETS(ph)PEMR ddPTM_A459_Selumetinib_30min_R2 1 ANEAGGQVGPEAPRPPETSPEMR 23 1 Q8N3D4;E9PIH6 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 ANEAGGQVGPEAPRPPET(0.346)S(0.654)PEMR 45.511 0.042165 28713000.0 16748.0 15319.0 21199.0 25561.0 20963.0 16884.0 18520.0 14190.0 15154.0 17612.0 True False 15817.213207556031 16493.91804165141 19835.079419726033 22079.54770481555 18329.440528402207 19209.61774230808 19381.21669668381 14231.290550719043 18185.223438137484 17103.495798528536 0.9247941703775454 0.9643594640500587 1.1597090824808167 1.2909377103314235 1.071678020932957 1.123139852144188 1.1331728276479731 0.8320691113885269 1.0632459967454146 1.0 14.062003608506027 -7.732171166451077 24.990467439755406 0.9607429452802151 1.1005076276000114 0.22756627987313882 0.10963364342683192 296.63398184659206 253279.11773447398 0.05495066858012592 0.03171962831707292 1.8528012436131073e-08 7.732171166451077 0.13976468231979633 ANGLPAGPEPASEPGS(ph)PYPEGPR ddPTM_A459_Selumetinib_30min_R2 2 ANGLPAGPEPASEPGSPYPEGPR 23 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5;A0A5F9ZH45 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 ANGLPAGPEPASEPGS(0.996)PY(0.004)PEGPR;ANGLPAGPEPAS(0.203)EPGS(0.659)PY(0.138)PEGPR 145.72 1.5016e-07 21864900.0 143536.0 103467.0 151136.0 143475.0 156677.0 94317.0 125897.0 129354.0 103958.0 107787.0 True False 135558.843740134 111402.58620115828 141412.07430443502 123933.45749181995 136993.83454984834 107308.31062551937 131751.4599601729 129730.39872429258 124752.50482921283 104674.9092457412 1.2950462027331477 1.0642721068868832 1.3509643841433616 1.1839843796842107 1.3087552264147013 1.0251579045900658 1.2586727890144633 1.2393648072789782 1.1918090565174146 1.0 16.675556141683636 ANHLGDSGGT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 ANHLGDSGGTPVK 13 0 H7C380;H7C0Z7;C9JIE2;H0Y8P0;Q86TI0-2;Q86TI0 H7C380 TBC1D1 TBC1 domain family member 1 1 ANHLGDSGGT(1)PVK 130.21 0.0019946 0.0 10213.0 10649.0 11420.0 12546.0 14320.0 11183.0 10257.0 10939.0 10403.0 11400.0 True False 9645.402345878294 11465.74405806815 10685.24963315587 10837.213156942831 12520.99357757571 12723.356740833402 10733.970823859921 10970.830678951059 12483.890684106114 11070.85237924286 0.8712429734825844 1.0356694918600564 0.9651695521828139 0.978896004183193 1.130987312327619 1.1492662267531344 0.9695704048936132 0.9909653117153531 1.1276359088223966 1.0 13.4344786835086 -6.101593441686547 8.03311552566888 1.0606569958574725 0.9663094542247012 0.3284199411695684 0.06926206338111125 0.3970794860034998 28.12721092181694 0.021098434445852122 0.027320569639826677 7.914191565891221e-07 6.101593441686547 -0.09434754163277137 ANHVSYKPTMTTTYEGSSMSLS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 ANHVSYKPTMTTTYEGSSMSLSR 23 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 ANHVSYKPTMTTTYEGS(0.04)S(0.106)MS(0.253)LS(0.601)R 80.733 0.00023331 8057400.0 11267.0 7807.7 15860.0 25338.0 31214.0 16901.0 8680.6 12566.0 19327.0 23554.0 True False 10640.825245374594 8406.525484287602 14839.584867062355 21886.920689512 27292.618263299475 19228.959337997425 9084.265100282579 12602.564979586718 23192.94004149948 22873.934819358452 0.46519435022474365 0.36751549528649835 0.6487552309759779 0.956849832018795 1.1931754846219744 0.8406493893531495 0.39714483633985304 0.5509574578712637 1.0139462328917301 1.0 14.481416941892164 -5.477239374179578 4.0689411080627 0.8264104843007953 0.42382753902322134 0.38054864955695555 0.21994233393195112 0.26629140909071203 9.250262358342818 0.06674500507786373 0.1408640458828382 3.332426856252142e-06 5.477239374179578 -0.402582945277574 ANIVDQSHLHDS(ph)SQK ddPTM_A459_Selumetinib_30min_R2 1 ANIVDQSHLHDSSQK 15 0 Q99570;D6RJ98 Q99570 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 1 ANIVDQSHLHDS(0.941)S(0.059)QK 81.016 0.018578 9154500.0 26649.0 21608.0 31463.0 33947.0 28463.0 24182.0 26117.0 27178.0 17437.0 26151.0 True False 25167.955264399352 23265.264119329186 29438.70483432425 29323.360038158637 24887.223477551513 27512.85099766013 27331.492249853713 27257.083480439876 20924.887230487202 25395.9526815421 0.9910222931975905 0.9161012548365035 1.1591888362479286 1.154646978826315 0.9799680992333737 1.0833557355639822 1.076214489473292 1.0732845434954073 0.8239457480835326 1.0 14.632310974518393 -8.242538092639496 24.639182262452003 0.9119728649513377 1.0556940768196463 0.3260068316385166 0.08179186926281014 693.2060831768515 903647.6540047204 0.0567622048459176 0.021370669606917837 5.7208677383748744e-09 8.242538092639496 0.14372121186830866 ANLACS(ph)PLGGGEPSPGAGEPSK ddPTM_A459_Selumetinib_30min_R2 1 ANLACSPLGGGEPSPGAGEPSK 22 0 Q9ULL5;Q9ULL5-2 Q9ULL5 PRR12 Proline-rich protein 12 1 ANLACS(0.999)PLGGGEPS(0.001)PGAGEPSK 193.42 6.120800000000001e-22 5643400.0 31721.0 30163.0 26489.0 33932.0 32639.0 26823.0 25374.0 28995.0 26362.0 30133.0 True False 29958.07380922405 32476.405110668573 24784.726579042544 29310.40306403508 28538.597023637838 30517.624775049142 26553.941277627142 29079.37064961936 31635.1366158229 29262.981995063612 1.0237532803142788 1.1098118816512628 0.8469651720123224 1.001620513896344 0.975245688510215 1.042874741207071 0.9074243111008489 0.9937254738606193 1.0810633250281687 1.0 14.836789171933681 -8.073660344631582 10.57853622411874 1.0396829542087669 0.9857565871244358 0.08392077498646644 0.0701030217142163 1.759667833453629 246.1910332397527 0.046906134163608726 0.01771650612189631 8.439945755388661e-09 8.073660344631582 -0.05392636708433107 ANLHMNLYETS(ph)PLT(ph)QT(ph)T(ph)EK ddPTM_A459_Selumetinib_30min_R2 1 ANLHMNLYETSPLTQTTEK 19 0 H7C5G6;Q0VF49-2;Q0VF49 H7C5G6 KIAA2012 Uncharacterized protein KIAA2012 4 ANLHMNLY(0.134)ET(0.501)S(0.527)PLT(0.927)QT(0.955)T(0.955)EK 42.325 0.047987 3576200.0 9164.5 8305.5 11047.0 9930.8 11463.0 9210.1 12579.0 10824.0 8483.8 8334.7 True False 8655.17377840024 8942.505143608316 10336.248047064177 8578.207908414464 10022.915459479773 10478.707674036465 13163.948424815628 10855.496047990331 10180.797057177688 8094.055554848727 1.069324730939779 1.1048237911156078 1.2770171858867794 1.0598157932429444 1.2383057407452023 1.2946177108655026 1.6263723834870136 1.3411689571969108 1.257811611025934 1.0 12.982647035872253 -6.615631087668159 2.9568949580636823 1.3465945491234597 1.1373044592099857 0.1983907003916786 0.15506264833388142 0.3507455728362203 6.186766427433813 0.05407447610191298 0.05449222694680588 2.4230864685057854e-07 6.615631087668159 -0.20929008991347398 ANLPQS(ph)FQVDTSK ddPTM_A459_Selumetinib_30min_R2 2 ANLPQSFQVDTSK 13 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 ANLPQS(0.823)FQVDT(0.137)S(0.04)K;ANLPQS(0.986)FQVDT(0.007)S(0.007)K 105.0 0.0074503999999999985 4443400.0 23067.4 22994.8 28132.0 21471.0 26420.0 18983.9 18160.6 19130.1 17608.7 25423.3 True False 21785.406254118585 24758.42722006438 26322.01774780567 18546.612760459084 23100.883402203242 21598.7599063138 19005.103884546203 19185.765423841458 21130.93202818606 24689.26327133377 0.8823838125381895 1.0028013775854914 1.066132166785538 0.7512015468680753 0.9356651572922888 0.8748239940959156 0.7697720128657166 0.7770894259982914 0.8558753574765748 1.0 14.591596166591051 -5.758465105594855 24.999985082960222 0.8437763795515194 0.9856753365553578 0.33959816133128196 0.08359987897180685 81.70640765056721 686760.7738978608 0.022737028202326256 0.03730116541331797 1.7439534738544524e-06 5.758465105594855 0.14189895700383837 ANNSQEPS(ph)PQLASSVASTR ddPTM_A459_Selumetinib_30min_R2 1 ANNSQEPSPQLASSVASTR 19 0 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 ANNSQEPS(0.994)PQLAS(0.006)SVASTR 225.83 1.0724e-20 10427000.0 30223.0 23789.0 29031.0 29145.0 33093.0 23693.0 29226.0 34011.0 26126.0 30479.0 True False 28543.326652254946 25613.539806308876 27163.17706656288 25175.400722070684 28935.561484826318 26956.495686360176 30585.066910220354 34109.966379175865 31351.930021431937 29598.992076047634 0.9643344131083786 0.8653517572659543 0.9177061501544883 0.8505492571297166 0.9775860411220494 0.9107234333217096 1.0333144733996087 1.152402970058519 1.0592228931607044 1.0 14.853260428658883 -7.354935954850721 3.4888041410036514 1.0815589833133485 0.9115115875360666 0.6701768839300466 0.050591024733841194 0.13241444860094265 3.041324982693286 0.021977365799396482 0.014239114644252064 4.416355702865963e-08 7.354935954850721 -0.1700473957772819 ANNT(ph)FYGLSAGVFTK ddPTM_A459_Selumetinib_30min_R1 1 ANNTFYGLSAGVFTK 15 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 ANNT(0.609)FY(0.001)GLS(0.381)AGVFT(0.009)K 103.04 0.013813999999999998 24678000.0 511.14 871.7 890.74 867.74 965.22 764.29 830.07 565.25 390.98 492.03 True False 523.0485674946945 769.6409587576646 769.7824004845894 716.2054984971654 877.9160214234322 756.6019365197965 767.4571516068088 550.2577338092364 663.4645039506305 555.1868432780584 0.9421126848150688 1.386273770850509 1.3865285350414067 1.2900260645017894 1.5812983179497626 1.3627879436992743 1.3823403074096938 0.9911217105943677 1.195029226617214 1.0 9.116829569358039 -7.756049248620224 24.999828556369508 1.06980658117554 1.3461930047300232 0.37634967407443065 0.15914478425427184 134.16257516725582 622265.0723416758 0.0771220234799622 0.042856085860394744 1.7536816245798007e-08 7.756049248620224 0.2763864235544833 ANNTFYGLS(ph)AGVFTK ddPTM_A459_Selumetinib_30min_R2 1 ANNTFYGLSAGVFTK 15 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 ANNTFYGLS(0.99)AGVFT(0.009)K 81.60600000000002 0.026964 9577600.0 52307.0 46272.0 51263.0 48682.0 67076.0 45706.0 61664.0 57115.0 48090.0 48701.0 True False 49399.98634151143 49820.91361206959 47964.794390934236 42051.42761886587 58649.31321295167 52001.58662224189 64531.49818489795 57281.19519410273 57709.34374686759 47294.87558960586 1.0445103349075775 1.053410395755833 1.0141647227733823 0.8891328520189118 1.2400775450150716 1.0995184144996555 1.3644501096664317 1.2111501400522047 1.220202887256364 1.0 15.529396255250205 -6.276251481530645 24.96656323576581 1.2040658060655278 1.0050878568399892 0.464018486454596 0.09865127553880546 660.2829280504935 1112938.4051637326 0.029775020000612946 0.03389016639686351 5.293568270195025e-07 6.276251481530645 -0.19897794922553858 ANNTFYGLSAGVFT(ph)K ddPTM_A459_Selumetinib_30min_R1 2 ANNTFYGLSAGVFTK 15 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 ANNTFYGLS(0.002)AGVFT(0.998)K;ANNTFYGLS(0.028)AGVFT(0.972)K 238.07 1.3423e-19 47046000.0 2732.9 7286.1 5377.8 6587.7 5621.9 5433.0 5810.6 6765.2 1580.48 4090.7999999999997 True False 2796.5712527022956 6433.040024784009 4647.524298140901 5437.281861444412 5113.400137627058 5378.348952769311 5372.301763859099 6585.764919533381 2681.9591263079747 4615.89402776636 0.6058569013672876 1.3936715154392247 1.0068524689224392 1.1779477233959645 1.1077810943812856 1.165180335687192 1.16387025602032 1.4267582574291129 0.5810270145230739 1.0 12.172394387464609 -8.269425955789664 24.997642007974218 0.790513538991516 1.1386353036372092 0.25487209440728953 0.23256956441897272 844.3025063691089 2642596.439141656 0.19362953249755022 0.05348971456676818 5.377421066232212e-09 8.269425955789664 0.3481217646456932 ANNTFYGLSAGVFTK ddPTM_A459_Selumetinib_30min_R2 2 ANNTFYGLSAGVFTK 15 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 183.0 7.0267e-13 3219300.0 34706.3 24897.4 29029.4 31371.0 33520.0 24163.4 25190.8 28954.2 22464.5 29693.0 False True 32777.46278632684 26806.95052224113 27161.68000882093 27098.215682006514 29308.91792739789 27491.689016494132 26362.222114623226 29038.45192837414 26958.02771057406 28835.685938320883 1.1366978700086192 0.9296449746186309 0.9419467276387797 0.9397458322985348 1.0164113310877794 0.9533911929578668 0.9142221263961482 1.0070317727307396 0.9348842184034357 1.0 14.815567720933336 -4.755671387528519 24.998670405147923 0.9588932309790914 1.1366981558235698 0.7115675541419868 0.033803706391758 99.2284774948837 430015.870951259 0.008196538974263291 0.07105475602864439 1.7552080920697332e-05 4.755671387528519 0.1778049248444784 ANPFGGASHAK ddPTM_A459_Selumetinib_30min_R1 1 ANPFGGASHAK 11 0 D6RD47;P62266;D6RDJ2;D6RIX0;D6R9I7 D6RD47 RPS23 40S ribosomal protein S23 0 120.55 0.0066005 10243000.0 5536.5 5538.3 6941.2 6395.7 6047.2 5223.2 5148.8 5242.3 3321.8 4422.1 False True 5665.489677846339 4889.873261314185 5998.6231652823835 5278.811057158043 5500.231827719873 5170.65935028615 4760.421870677339 5103.2571746097465 5636.851985327135 4989.71960990164 1.135432473320484 0.9799895873128183 1.2021964427377176 1.0579374132932695 1.1023128066765853 1.0362625066197009 0.9540459670781338 1.0227542975526724 1.1296931342878105 1.0 12.284743032334875 -6.825120201912115 5.535351562255059 1.0243279400677008 1.092971088325335 0.200938894035248 0.06671274298998701 0.342650308496334 20.172994213342253 0.02330117851378495 0.020734274005620293 1.495821592578619e-07 6.825120201912115 0.06864314825763418 ANPFGGASHAK ddPTM_A459_Selumetinib_30min_R2 2 ANPFGGASHAK 11 0 D6RD47;P62266;D6RDJ2;D6RIX0;D6R9I7 D6RD47 RPS23 40S ribosomal protein S23 0 ; 126.66 0.0043787 17936300.0 277317.0 256472.0 259957.0 304127.0 307700.0 243534.0 260640.0 268000.0 215422.0 277470.0 False True 261904.8313279086 276142.5777125408 243231.64963978066 262704.3779516623 269043.9751270984 277078.59791845846 272760.27644836233 268779.8356302115 258512.4193935888 269458.72014636075 0.9719664339890388 1.0248047551125814 0.9026675756036604 0.9749336663106329 0.9984608216834212 1.0282784604927941 1.0122525494821926 0.9974805620846842 0.959376706210041 1.0 18.03970475000598 -6.231734699172723 4.9487790487978645 1.0013928627607374 0.9674866169381977 0.18230771611498642 0.03187781570922207 0.34416727633668803 22.817945206652883 0.009942963163166892 0.012564649393727546 5.86496332652793e-07 6.231734699172723 -0.03390624582253965 ANQIS(ph)PSNSSLK ddPTM_A459_Selumetinib_30min_R1 1 ANQISPSNSSLK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 ANQIS(0.534)PS(0.45)NS(0.014)S(0.002)LK 142.38 0.00091324 9983900.0 3469.4 4780.7 2510.5 2942.7 3024.8 2978.4 3852.7 3912.5 1800.8 3420.2 True False 3550.2302697227638 4220.973421512865 2169.5878891893954 2428.812686320336 2751.207374071813 2948.4400001708304 3562.087737173437 3808.7277904089106 3055.826074771844 3859.2159855692075 0.9199356250072979 1.0937385824728076 0.5621835878847284 0.6293539142153255 0.7128928218476036 0.7639997375622282 0.9230081318312258 0.9869174994742228 0.7918256159278245 1.0 11.914092072928367 -7.264561087442116 22.47257653695844 0.9243476332497099 0.7747491666375045 0.18596550506257126 0.1484254589130496 130.78080342627118 941442.3653255028 0.06585735019113861 0.04664285211860258 5.437996360093622e-08 7.264561087442116 -0.14959846661220544 ANQIS(ph)PSNSSLK ddPTM_A459_Selumetinib_30min_R2 1 ANQISPSNSSLK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 ANQIS(0.733)PS(0.263)NS(0.004)SLK 164.92 0.00051468 16515000.0 55255.0 46567.0 62374.0 66289.0 65545.0 47792.0 62608.0 63425.0 59103.0 50159.0 True False 52184.148303290436 50138.53916349512 58360.92474767639 57260.323845096784 57310.651120265335 54374.91418741932 65519.39605539846 63609.55624942601 70925.25147579775 48710.77934126689 1.0713059616166103 1.0293109624098882 1.1981110862300262 1.175516479503067 1.1765496650905107 1.116280932531783 1.3450697554307371 1.3058620106194265 1.4560483826156145 1.0 15.571953445108973 -7.255616263314205 24.758128365249412 1.3022335399319067 1.1309415146450617 0.2659551795522608 0.11812328931087643 482.99303407352005 2053545.2772662498 0.04428965897177284 0.0333372594673737 5.551159892484603e-08 7.255616263314205 -0.17129202528684506 ANQISPS(ph)NSSLK ddPTM_A459_Selumetinib_30min_R1 1 ANQISPSNSSLK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 ANQIS(0.187)PS(0.808)NS(0.004)SLK 152.16 0.00050313 12738000.0 2174.8 3407.5 2098.2 1997.9 2106.1 2166.5 2641.7 2179.9 1306.2 2212.3 True False 2225.4686085758544 3008.548315896228 1813.2759645876079 1649.0042702278179 1915.603626862156 2144.7069770246117 2442.4344421551295 2122.0819706868706 2216.5259989265787 2496.2702546268497 0.8915174967337519 1.2052173879490284 0.7263940918362872 0.6605872369673836 0.7673863129649423 0.85916457685196 0.9784334999898608 0.8501010524615997 0.8879351083153904 1.0 11.285558418342816 -9.794235702353914 15.619190768573958 0.9999998652840437 0.8684557192078565 0.07084160063320988 0.14157820519349137 0.0 0.0 0.14746449672290948 0.035765393883359135 1.6060693628803922e-10 9.794235702353914 -0.13154414607618725 ANQISPS(ph)NSSLK ddPTM_A459_Selumetinib_30min_R2 2 ANQISPSNSSLK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 ANQIS(0.423)PS(0.469)NS(0.102)S(0.007)LK;ANQIS(0.419)PS(0.574)NS(0.007)SLK 142.95 0.00086624 36570000.0 91035.0 80967.0 87364.0 99436.0 98833.0 81399.0 110680.0 94018.0 88048.0 88253.0 True False 85975.6391419789 87176.90855006137 81743.09535473114 85892.6452633324 86416.7149617696 92610.97338344782 115826.83930825947 94291.5768144822 105660.06026667076 85704.90658116844 1.0031588921989438 1.0171752356733375 0.953773810806442 1.00219052431947 1.0083053399040465 1.0805795966388325 1.351461006477657 1.1001887823678052 1.2328356039523058 1.0 16.3870901801263 -7.006520764021296 6.4765158765379285 1.1848094085781737 0.9999129555462705 0.47372049725476506 0.08601520783583659 0.11626979439472393 23.327320222994008 0.02989168880171724 0.024762611440399495 9.850975432524557e-08 7.006520764021296 -0.18489645303190327 ANQISPS(ph)NSSLKNPQAGVPPFSSLK ddPTM_A459_Selumetinib_30min_R1 2 ANQISPSNSSLKNPQAGVPPFSSLK 25 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 ANQIS(0.016)PS(0.328)NS(0.328)S(0.328)LKNPQAGVPPFSSLK;ANQIS(0.042)PS(0.319)NS(0.319)S(0.319)LKNPQAGVPPFSSLK 84.602 5.841e-05 54667000.0 4874.6 4920.799999999999 6976.1 7097.8 6147.299999999999 4730.9 5527.2 4995.5 2834.5 4083.1 True False 4988.168695679539 4344.670448382145 6028.783936974364 5858.302472207318 5591.277800393962 4683.311441313515 5110.278854025751 4863.003112329125 4809.939476310965 4607.205657762007 1.082688524501984 0.9430163902196216 1.3085554205329097 1.2715521961424754 1.2135941426825685 1.0165188596309542 1.1091926937136374 1.0555211713061174 1.0440036398651755 1.0 12.169676283474875 -6.7651265701640435 24.995457779990918 1.0525264290090064 1.165630226138153 0.26373799462294734 0.0988595576154894 160.4423825566538 1087628.8407598461 0.03773989909122467 0.034566647160057286 1.7174077953382118e-07 6.7651265701640435 0.11310379712914664 ANQISPS(ph)NSSLKNPQAGVPPFSSLK ddPTM_A459_Selumetinib_30min_R2 2 ANQISPSNSSLKNPQAGVPPFSSLK 25 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 ANQIS(0.005)PS(0.332)NS(0.332)S(0.332)LKNPQAGVPPFSSLK;ANQIS(0.097)PS(0.301)NS(0.301)S(0.301)LKNPQAGVPPFSSLK 84.94200000000002 5.6538e-05 37781000.0 112454.0 102085.0 121597.0 137281.0 131549.0 94324.0 81739.0 90365.0 83036.0 119852.0 True False 106204.25686902949 109914.59124498916 113773.58140480335 118583.09097706612 115022.63855701877 107316.27481197972 85540.0254627558 90627.947189269 99645.52021969015 116391.56134710659 0.9124738566939901 0.9443518926359137 0.9775071327164706 1.0188289391824883 0.988238642267154 0.9220279680924439 0.7349332243052883 0.7786470611816563 0.856123236653937 1.0 16.82862693780323 -7.045471753439837 6.758382252234453 0.8239475744620713 0.9690030211117133 0.41013199047705107 0.0698222040868197 0.19525350886522236 23.174930874644073 0.0260843906147088 0.02047505615697664 9.005923354689268e-08 7.045471753439837 0.14505544664964198 ANS(ph)DTDLVTSESR ddPTM_A459_Selumetinib_30min_R1 1 ANSDTDLVTSESR 13 0 A0A2R8Y6F3;Q9P2P5;C9JHL2 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 ANS(0.806)DT(0.194)DLVTSESR 165.58 0.00035441 18503000.0 834.55 889.18 1076.0 1009.8 1001.4 829.18 858.79 707.51 555.46 826.05 True False 853.9933912483806 785.0743922314327 929.8851100449265 833.4573862936331 910.8235468115299 820.8392020352029 794.010778884204 688.7445364836317 942.5750508067342 932.08156390838 0.9162217388652533 0.8422807859641375 0.9976434960753399 0.8941893269498878 0.9771929647361424 0.8806516873837538 0.8518683446057862 0.7389316162371093 1.011258120860532 1.0 9.86431239647554 -6.957095133468596 24.90048365706965 0.876973148563248 0.923727206125381 0.0026156582430996167 0.08290857540475467 393.27215328290663 228240.08500230638 0.028241960018401756 0.024907059506269216 1.1038367947584485e-07 6.957095133468596 0.04675405756213291 ANS(ph)DTDLVTSESR ddPTM_A459_Selumetinib_30min_R2 2 ANSDTDLVTSESR 13 0 A0A2R8Y6F3;Q9P2P5;C9JHL2 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 ANS(0.774)DT(0.226)DLVTSESR;ANS(0.5)DT(0.5)DLVT(0.001)SESR 228.49 5.6025e-13 55625000.0 92505.0 72489.0 95798.0 88805.0 101760.0 57314.0 78728.0 71599.0 49325.0 69827.0 True False 87363.94242685514 78048.6732111279 89634.46097697597 76709.60580283037 88975.99905405752 65208.483255309475 82389.00799657255 71807.34123614748 59191.37825565074 67810.913077666 1.2883463510776565 1.1509751110670972 1.32182943583601 1.1312280327942554 1.3121191710270952 0.9616222565920048 1.2149815458495565 1.0589348819695767 0.8728886777834265 1.0 16.049229850198238 -7.438003101940329 0.7252132699827252 0.9488475615590929 1.2396392324792567 0.5033541162015074 0.1043129732426954 0.5719961275817537 0.5786527074862122 0.08746976248588596 0.049817059497339375 3.647513416865714e-08 7.438003101940329 0.2907916709201638 ANS(ph)FVGTAQYVSPELLTEK ddPTM_A459_Selumetinib_30min_R1 1 ANSFVGTAQYVSPELLTEK 19 0 E9PER6;Q6A1A2;O15530-4;O15530-5;O15530;O15530-2 E9PER6 PDPK1;PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2;3-phosphoinositide-dependent protein kinase 1 1 ANS(1)FVGTAQYVSPELLTEK 227.24 1.1669e-23 36887000.0 4334.0 4767.7 5501.5 5266.5 4405.5 4380.0 4560.7 4260.7 2517.8 3588.0 True False 4434.973767504023 4209.495467556404 4754.42651757636 4346.804639448823 4007.023302854197 4335.941176721806 4216.6827271593675 4147.692395295909 4272.522707163784 4048.5547500796174 1.0954461632059704 1.0397526345601777 1.1743515429753943 1.073668236637615 0.9897416609656561 1.070984942623423 1.0415279000676585 1.0244871692088002 1.0553204713557998 1.0 11.98319127241013 -6.006277256828299 24.956267105512822 1.0339361938543643 1.1013686184342821 0.43245591290445784 0.03773559246846051 276.700403840555 1100077.8639900486 0.010484919097994667 0.0149874288085673 9.856500384131608e-07 6.006277256828299 0.06743242457991783 ANS(ph)FVGTAQYVSPELLTEK ddPTM_A459_Selumetinib_30min_R2 1 ANSFVGTAQYVSPELLTEK 19 0 E9PER6;Q6A1A2;O15530-4;O15530-5;O15530;O15530-2 E9PER6 PDPK1;PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2;3-phosphoinositide-dependent protein kinase 1 1 ANS(0.994)FVGT(0.005)AQYVSPELLTEK 135.98 0.00018176 97689000.0 27753.0 25406.0 26977.0 28903.0 27891.0 23537.0 26897.0 27891.0 15652.0 25838.0 True False 26210.599364061527 27354.558506834393 25241.329190336757 24966.361539543963 24387.083231296387 26779.00810238718 28147.763795394385 27972.15819239639 18782.837353420073 25091.989804813777 1.0445803448809448 1.0901709557361032 1.0059516756815488 0.9949932920327541 0.971907107447407 1.0672333406276833 1.1217828484050465 1.1147843758102463 0.7485591019097527 1.0 14.614939261125992 -8.248932606682605 24.990323231045544 0.8742795338744961 1.0495417022797733 0.48177257162748044 0.07346956339732746 565.189186808462 1129334.6662307219 0.05026726984522127 0.018706135094909024 5.6372512725475846e-09 8.248932606682605 0.1752621684052772 ANS(ph)GGVDLDSSGEFASIEK ddPTM_A459_Selumetinib_30min_R2 1 ANSGGVDLDSSGEFASIEK 19 0 Q92766;Q92766-2;A0A087X055;Q92766-5;Q92766-3 Q92766 RREB1 Ras-responsive element-binding protein 1 1 ANS(1)GGVDLDSSGEFASIEK 117.37 0.00045973 2972300.0 12091.0 11417.0 11968.0 11247.0 10635.0 8462.1 10097.0 12871.0 8594.5 7707.4 True False 11419.030624107945 12292.647188558934 11197.99190977316 9715.139197842827 9298.936221893691 9627.677463704396 10566.53050682593 12908.452479091236 10313.640150394122 7484.867335769856 1.5256156337650626 1.642333342344347 1.4960842199912405 1.2979707938729386 1.2423648683062796 1.2862856523447175 1.4117191438155408 1.7246067164613996 1.3779322582119369 1.0 12.869761030374892 -5.565628289521672 4.901161517358765 1.3627548311407287 1.5819551051103635 0.25417743124327774 0.1722719630377505 0.2928172183658225 16.10116746093933 0.04887935211093422 0.08932986002127942 2.7187652509004444e-06 5.565628289521672 0.21920027396963482 ANS(ph)LGDLYAQK ddPTM_A459_Selumetinib_30min_R2 1 ANSLGDLYAQK 11 0 Q13009-2;Q13009 Q13009-2 TIAM1 T-lymphoma invasion and metastasis-inducing protein 1 1 ANS(1)LGDLYAQK 93.823 0.023688 0.0 14265.0 12361.0 16868.0 16610.0 14572.0 14179.0 12661.0 13775.0 11489.0 16239.0 True False 13472.208407319478 13309.048953120515 15782.731244489762 14347.6893461518 12741.335084667133 16132.02854585324 13249.761587295556 13815.08296942598 13787.121029481425 15770.137876010942 0.85428602547686 0.8439399235288766 1.0007985579186327 0.909801135472447 0.8079406270790357 1.0229478443807898 0.840180453174775 0.876028039706683 0.8742549455102722 1.0 13.94490765300493 -6.952221249226357 0.008722701586952793 1.8024924459372824 2.2842385372532387e-06 0.0998798693412124 0.06959221893241749 9431.405536334532 37.31725502902642 3777.529602610948 3930.615393765098 1.1162944121005292e-07 6.952221249226357 -1.8024901616987452 ANS(ph)PEKPPEAGAAHKPR ddPTM_A459_Selumetinib_30min_R1 1 ANSPEKPPEAGAAHKPR 17 2 F8WDB4;Q9UFC0 F8WDB4 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 ANS(1)PEKPPEAGAAHKPR 51.029 0.038887 32059000.0 3293.8 3483.3 3992.6 4007.2 2782.4 3410.8 3269.1 3365.6 2520.3 2882.1 True False 3370.539131380885 3075.4736166577622 3450.426849781946 3307.417744460139 2530.7324112726187 3376.490448758615 3022.509155032492 3276.3333549904714 4276.765024571008 3252.045609031348 1.0364366114732417 0.9457043308730904 1.0610019860114102 1.0170268631150239 0.778197084396495 1.0382666342014601 0.9294178244728784 1.0074684518235764 1.3150999520713618 1.0 11.667131775611907 -8.027312825608357 22.739565012643137 1.1587950053581217 0.9712584561327595 0.3304599571121932 0.10402421411422143 253.0147475057663 210646.24757769448 0.06604441201079712 0.02517041503874288 9.390466644644915e-09 8.027312825608357 -0.18753654922536223 ANS(ph)PSLFGTEGKPK ddPTM_A459_Selumetinib_30min_R1 1 ANSPSLFGTEGKPK 14 1 Q5JPT2;Q96B97-2;Q96B97;Q96B97-3 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 ANS(0.5)PS(0.5)LFGTEGKPK 184.99 0.00037411 121290000.0 3023.5 2996.9 3590.9 3403.2 3000.6 2591.8 3267.4 3053.4 1426.2 2235.0 True False 3093.941667293129 2646.021554778988 3103.2755034017932 2808.895005975931 2729.1962597989564 2565.728845166115 3020.9373874011676 2972.413913158994 2420.1572344733477 2521.8840207435746 1.2268374127613069 1.0492241249059548 1.2305385489086829 1.1138081620215554 1.0822053026031926 1.0173857417953793 1.197889102969314 1.1786481411157763 0.9596623851717682 1.0 11.300286213561549 -14.522877064955523 0.05329355119378131 0.484641977035206 1.357238758096854 0.26565455435034624 0.08047264261480946 772.3296106381772 3.0208838100814184 53.759838380393205 10.862222626168544 3.000011607295063e-15 14.522877064955523 0.872596781061648 ANS(ph)TSDSVFTETPSPVLK ddPTM_A459_Selumetinib_30min_R2 2 ANSTSDSVFTETPSPVLK 18 0 C9JEZ4;Q9UKI2 C9JEZ4 CDC42EP3 Cdc42 effector protein 3 1 ANS(0.916)T(0.081)S(0.003)DSVFTETPSPVLK;ANS(0.647)T(0.198)S(0.008)DS(0.138)VFT(0.009)ETPSPVLK 222.93 1.4742999999999995e-51 0.0 31649.0 33560.0 31640.0 40072.0 35822.0 25378.0 29131.0 35585.0 23602.0 29483.0 True False 29890.075280985217 36133.94408759198 29604.316847027272 34614.12447194429 31321.72010725678 28873.589141453107 30485.64922198141 35688.546458586134 28323.059494979592 28631.74918396643 1.0439486281097852 1.2620236317181324 1.0339681539123524 1.2089420122235477 1.0939506317272685 1.0084465659409347 1.064749800164258 1.2464675570213315 0.9892186227602294 1.0 14.805328190366904 -6.507422133942578 24.362644722798642 1.0744590111248828 1.1403457367579266 0.1195322265602613 0.09325688796300138 1213.7229648026134 1913069.0105232815 0.02834989735643714 0.03112669514448404 3.108693220403365e-07 6.507422133942578 0.06588672563304376 ANSALT(ph)PPKPESGLTLQESNTPGLR ddPTM_A459_Selumetinib_30min_R1 1 ANSALTPPKPESGLTLQESNTPGLR 25 1 Q9BW04-2;Q9BW04 Q9BW04-2 SARG Specifically androgen-regulated gene protein 1 ANS(0.005)ALT(0.991)PPKPES(0.004)GLTLQESNTPGLR 101.16 4.2543e-06 13216000.0 3071.5 2887.5 3167.4 3165.3 3250.1 2493.1 2820.4 2341.3 1374.7 2270.2 True False 3143.059973901387 2549.4301576376674 2737.284477282808 2612.5397750398474 2956.1290288517594 2468.021677553684 2607.6549572829335 2279.2011183857844 2332.7654958845237 2561.6022836206093 1.2269898391326135 0.9952482373783109 1.0685829313885085 1.019885011715106 1.1540156127099948 0.9634679408800898 1.0179780733163748 0.8897560456435593 0.9106665428902397 1.0 11.322830783765161 -7.128503851346046 1.6808395764561075 0.9340358032350334 1.0809894051758917 0.43575512143108797 0.07362852274681737 0.3548528213360535 1.9828431578529109 0.036208917061209094 0.024688363961167418 7.438684662140817e-08 7.128503851346046 0.14695360194085827 ANSALT(ph)PPKPESGLTLQESNTPGLR ddPTM_A459_Selumetinib_30min_R2 2 ANSALTPPKPESGLTLQESNTPGLR 25 1 Q9BW04-2;Q9BW04 Q9BW04-2 SARG Specifically androgen-regulated gene protein 1 ANS(0.026)ALT(0.643)PPKPES(0.246)GLT(0.073)LQES(0.006)NT(0.006)PGLR;ANS(0.004)ALT(0.959)PPKPES(0.01)GLT(0.013)LQES(0.007)NT(0.007)PGLR 69.525 0.0018465 72370000.0 55948.0 64885.0 68405.0 70233.0 73161.0 55586.0 62537.0 63056.0 52867.0 62708.0 True False 52838.634137589244 69861.47086184166 64003.896773732675 60667.144241317204 63969.86111236154 63242.46694053169 65445.09441471459 63239.48252051724 63441.877227399644 60897.4571050492 0.8676656899883628 1.147198490428416 1.0510109915316301 0.9962180216600062 1.0504520903395422 1.0385075165197342 1.0746769656049946 1.0384585092186691 1.0417820421953132 1.0 15.894094366325897 ANSALTPPKPES(ph)GLTLQESNTPGLR ddPTM_A459_Selumetinib_30min_R1 1 ANSALTPPKPESGLTLQESNTPGLR 25 1 Q9BW04-2;Q9BW04 Q9BW04-2 SARG Specifically androgen-regulated gene protein 1 ANS(0.002)ALT(0.039)PPKPES(0.942)GLT(0.009)LQES(0.004)NT(0.004)PGLR 72.805 0.00034178 12771000.0 2117.6 2120.7 2742.3 3215.5 2358.9 2142.7 2044.9 2201.7 1256.1 1509.4 True False 2166.935959867678 1872.407458113318 2369.9107223756537 2653.9732874105553 2145.5379114976204 2121.146383415941 1890.6515466415647 2143.303763870492 2131.5099580858005 1703.1461928010522 1.2723135389240199 1.0993815246323 1.3914898981619528 1.5582768517632304 1.259749703558328 1.2454282505998098 1.1100935167122294 1.2584379267792283 1.2515132095502892 1.0 10.733986561473511 -6.822193106091465 2.863189803472955 1.1780008360169336 1.3244327029622651 0.25313162213732365 0.12824702573332256 0.45632850289686644 7.613422755008861 0.051810775759797 0.04644625142598211 1.5059373125000284e-07 6.822193106091465 0.1464318669453315 ANSDT(ph)DLVTSESR ddPTM_A459_Selumetinib_30min_R1 1 ANSDTDLVTSESR 13 0 A0A2R8Y6F3;Q9P2P5;C9JHL2 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 ANS(0.305)DT(0.695)DLVTSESR 151.11 0.0011095 3799200.0 926.72 1127.2 845.84 1275.1 1250.7 1032.6 1233.9 1272.8 698.15 844.0 True False 948.3107729167806 995.2268999789368 730.9795738665433 1052.427721591416 1137.5744058290197 1022.2129815257847 1140.8259295814114 1239.041209362929 1184.7095591414718 952.3356212561871 0.9957737080819287 1.0450379863625952 0.7675650868780252 1.1051017079495582 1.1945099820255507 1.0733747207496294 1.197924244476537 1.3010551970413122 1.2440042488159475 1.0 9.895326286198054 -5.985920305299137 24.441920590624214 1.1774805136269793 0.9452361475546811 0.5013897590780336 0.10335514759033664 147.38684990752438 255856.17749898747 0.0293607263951694 0.04352426120993473 1.0329509388245243e-06 5.985920305299137 -0.23224436607229815 ANSFVGT(ph)AQYVSPELLTEK ddPTM_A459_Selumetinib_30min_R2 2 ANSFVGTAQYVSPELLTEK 19 0 E9PER6;Q6A1A2;O15530-4;O15530-5;O15530;O15530-2 E9PER6 PDPK1;PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2;3-phosphoinositide-dependent protein kinase 1 1 ANS(0.019)FVGT(0.973)AQYVS(0.008)PELLTEK;ANS(0.289)FVGT(0.702)AQY(0.008)VS(0.001)PELLTEK 185.2 7.8999e-14 81224000.0 185504.0 161623.0 173089.0 216393.0 189589.0 133083.0 169476.0 135550.0 129713.0 155678.0 True False 175194.43031134902 174018.96440014525 161952.6421850536 186919.90010125417 165771.13487283545 151413.97524280875 177356.9698103229 135944.42805848955 155659.22448403868 151183.17163998 1.158822297554044 1.1510471867500258 1.071234585359272 1.2363803330332017 1.0964919777420368 1.0015266487686763 1.1731263994955197 0.8992034403288005 1.0296068193007468 1.0 17.205938035009602 -7.190678518004083 0.8838614374467447 0.9830204234056761 1.149007609955933 0.41414811019599884 0.07361129067760816 0.5803795363277223 0.8981694713684722 0.05442975272391967 0.03368722323556168 6.446462816791235e-08 7.190678518004083 0.1659871865502569 ANSGGVDLDS(ph)SGEFASIEK ddPTM_A459_Selumetinib_30min_R1 1 ANSGGVDLDSSGEFASIEK 19 0 Q92766;Q92766-2;A0A087X055;Q92766-5;Q92766-3 Q92766 RREB1 Ras-responsive element-binding protein 1 1 ANS(0.248)GGVDLDS(0.376)S(0.376)GEFASIEK 81.185 0.0058785 4933900.0 729.49 640.96 665.39 658.66 690.93 580.6 874.63 620.97 430.32 512.95 True False 746.4856976595547 565.9161052257805 575.0336927256448 543.6373955794858 628.435503493599 574.7596911426213 808.6559549313471 604.499858405168 730.2216106707125 578.7921290561151 1.2897302160568624 0.9777536300444641 0.9935064142344169 0.9392619012736765 1.0857706453583629 0.9930330118343699 1.3971440079015764 1.0444161695684713 1.2616301673997299 1.0 9.176901492693222 ANSPS(ph)LFGTEGKPK ddPTM_A459_Selumetinib_30min_R1 1 ANSPSLFGTEGKPK 14 1 Q5JPT2;Q96B97-2;Q96B97;Q96B97-3 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 ANS(0.097)PS(0.903)LFGTEGKPK 192.4 0.00052645 116920000.0 2758.6 2622.9 2996.7 3396.1 2784.4 2219.1 2735.4 2729.1 1472.8 1950.8 True False 2822.8700126987997 2315.8096486468717 2589.7645996948254 2803.0348876924227 2532.5515116257457 2196.7778687815908 2529.0665757168254 2656.7154026338553 2499.234030944008 2201.204182401147 1.282420792795114 1.0520648957338927 1.1765217513215078 1.2734097591231988 1.1505300289149705 0.997989139919438 1.1489468337090087 1.2069372863610595 1.135394004302572 1.0 11.104077259639373 -6.524491666472638 24.997192591914303 1.1095669518434081 1.1878611329719977 0.22465282501198947 0.08425118109264844 104.42614637379835 1618364.7901420374 0.028228257367657165 0.02842702182384326 2.988878998979684e-07 6.524491666472638 0.07829418112858955 ANSPS(ph)LFGTEGKPK ddPTM_A459_Selumetinib_30min_R2 1 ANSPSLFGTEGKPK 14 1 Q5JPT2;Q96B97-2;Q96B97;Q96B97-3 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 ANS(0.02)PS(0.98)LFGTEGKPK 92.906 0.008310799999999998 328630000.0 244260.0 214900.0 255610.0 274230.0 226240.0 170600.0 187780.0 200730.0 151360.0 168270.0 True False 230685.00705025278 231382.1389875901 239164.33088712534 236879.40092686334 197817.70858873831 194098.60144739135 196512.1420790109 201314.09106735952 181636.22935175436 163411.60788203508 1.411680663571841 1.4159467738339748 1.463570024106092 1.4495873579425507 1.210548694506088 1.1877895576886366 1.2025592589534442 1.2319448641169102 1.1115258683634972 1.0 17.31815094285944 -6.8738173861890886 0.347405109298574 1.0099515442314855 1.5277100248284565 0.8439240977818986 0.05930919941530412 0.751577390328452 0.19606369386225517 0.08008350027029454 0.1438604394904316 1.337157651536192e-07 6.8738173861890886 0.517758480596971 ANST(ph)SDSVFTETPSPVLK ddPTM_A459_Selumetinib_30min_R2 1 ANSTSDSVFTETPSPVLK 18 0 C9JEZ4;Q9UKI2 C9JEZ4 CDC42EP3 Cdc42 effector protein 3 1 ANS(0.14)T(0.778)S(0.081)DS(0.002)VFTETPSPVLK 134.83 0.00085891 1977000.0 14563.0 12745.0 12463.0 16382.0 13423.0 8840.4 11749.0 13011.0 9527.7 11183.0 True False 13753.646760307995 13722.500518365912 11661.144148688407 14150.74333947373 11736.682736857454 10058.084854838911 12295.351780201838 13048.859855912993 11433.506226180703 10860.11773307657 1.2664362485149334 1.263568301526917 1.073758538839055 1.3030009146562869 1.0807141345356817 0.9261487860490762 1.1321563985217202 1.201539447051314 1.0527976314066807 1.0 13.406752122839517 -6.342539735549769 8.527524537639126 1.0715495596449367 1.2182414000615174 0.43698577016741735 0.089260805399501 0.39061229034826145 38.07621390773461 0.02876300754628691 0.032621990345852704 4.544229581130839e-07 6.342539735549769 0.14669184041658068 ANSTS(ph)DSVFTETPSPVLK ddPTM_A459_Selumetinib_30min_R1 1 ANSTSDSVFTETPSPVLK 18 0 C9JEZ4;Q9UKI2 C9JEZ4 CDC42EP3 Cdc42 effector protein 3 1 ANS(0.005)T(0.049)S(0.517)DS(0.429)VFTETPSPVLK 261.76 9.9768e-43 7490700.0 3003.6 2753.0 3155.4 3048.9 2945.8 2958.7 2818.1 2298.0 1706.1 2274.6 True False 3073.5780360117874 2430.6774801650213 2726.9140113715252 2516.4668499412364 2679.352910123232 2928.9381642846606 2605.5284481346735 2237.049575044006 2895.127091386182 2566.56706648024 1.1975444071394776 0.9470539507461317 1.0624752600411036 0.9804796776233435 1.0439442417523361 1.1411890234769404 1.0151803481636132 0.8716115796311021 1.1280153669845556 1.0 11.325624244495307 -4.745636898501305 24.745162285867288 1.021397770085655 1.1975449650811205 0.32553671631568537 0.07618837886458994 970.9867697313548 1520376.8221613716 0.01867614506700048 0.45868800859513964 1.7962347809906234e-05 4.745636898501305 0.1761471949954656 ANSTSDSVFTETPS(ph)PVLK ddPTM_A459_Selumetinib_30min_R2 2 ANSTSDSVFTETPSPVLK 18 0 C9JEZ4;Q9UKI2 C9JEZ4 CDC42EP3 Cdc42 effector protein 3 1 ANSTSDSVFTET(0.001)PS(0.999)PVLK;ANSTSDSVFTET(0.008)PS(0.992)PVLK 182.82 2.3125e-14 0.0 36371.0 33892.0 35464.0 40169.0 35919.0 30192.0 30406.0 32104.0 32550.0 46294.0 True False 34349.64542464891 36491.4074200437 33182.28485028367 34697.912904609955 31406.534100065775 34350.673944312104 31819.939248345985 32197.417324896676 39060.909522988964 44957.371933742885 0.764049230352535 0.8116890701223345 0.7380832869676399 0.7717958459793184 0.6985847425946513 0.7640721080168413 0.707780234468364 0.7161765899561138 0.8688432584661757 1.0 15.456270082168484 -8.525111550858481 3.327612209927258 0.9993469332085972 0.7474533889101889 0.8591537977842305 0.03258341983152658 0.07685143552093987 2.225265784455931 0.032898819295438295 0.008711973688948431 2.984615905910236e-09 8.525111550858481 -0.2518935442984084 ANSWQLVET(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 ANSWQLVETPEK 12 0 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 ANSWQLVET(1)PEK 130.47 0.005058600000000001 3887100.0 35856.0 35135.0 32854.0 38291.0 35129.0 30051.0 33851.0 30071.0 24510.0 33841.0 True False 33863.26706294059 37829.7415231688 30740.20940873055 33075.699744340665 30715.780962755405 34190.252474182664 35425.13857448399 30158.50163147795 29412.68486661936 32863.922400522606 1.030408563233526 1.1511024479100895 0.9353785903608911 1.006444067790724 0.9346352692905263 1.0403582401849563 1.0779339770447078 0.9176780928316203 0.8949840042876815 1.0 15.004217059778718 -5.266801218279327 24.998244617704007 0.9785459414341982 1.0907555066778674 0.36441710425748775 0.06058044014656942 446.325785066189 2080893.69778948 0.016302250415101093 0.03562214188167744 5.410018892472661e-06 5.266801218279327 0.11220956524366921 ANSWQLVET(ph)PEKR ddPTM_A459_Selumetinib_30min_R1 1 ANSWQLVETPEKR 13 1 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 ANSWQLVET(1)PEKR 204.17 0.005558899999999999 21396000.0 2362.8 3210.9 3011.7 3414.7 3099.5 2547.2 2742.8 2457.9 1496.3 2163.7 True False 2417.8486427915327 2834.9663352930884 2602.7276820839274 2818.386746857665 2819.150772261171 2521.577480672554 2535.908387759053 2392.708507615606 2539.1118145719183 2441.431971222762 0.9903403704427538 1.1611899773202483 1.0660660271358626 1.1543990494423277 1.1547119909506358 1.0328272548219528 1.0386971325229977 0.9800430795609048 1.040009242321929 1.0 11.253511863519334 -6.894002320893129 6.262662753905341 1.0161848769710997 1.1087317380043584 0.42841220397121627 0.0504687227174442 0.1996659967357189 10.41869934240161 0.017396338468382816 0.015336928320695184 1.276431987471748e-07 6.894002320893129 0.09254686103325871 ANSWQLVET(ph)PEKR ddPTM_A459_Selumetinib_30min_R2 3 ANSWQLVETPEKR 13 1 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 ANSWQLVET(1)PEKR;ANSWQLVET(1)PEKR;ANSWQLVET(1)PEKR 113.81 0.0055444 76100000.0 95464.0 99424.0 94443.0 112224.0 100122.0 75223.0 86142.0 97520.0 66698.0 86192.0 True False 90158.49305267072 107049.50110145246 88366.64020176354 96938.89760280208 87543.7792579633 85584.28544359401 90147.77368713486 97803.76705469491 80039.46369782835 83703.41300628953 1.0771184807708636 1.2789144104961252 1.055711314843561 1.1581235952172946 1.045880641108209 1.0224706779538746 1.0769904171095281 1.1684561422524775 0.9562270022587267 1.0 16.35299882940823 -4.3021239150921975 0.1841490482897428 0.9887133619600185 1.3603582608510352 0.2650101392169695 0.07674596904078616 27.812792427888883 0.78852721669756 0.19575437621134792 2.4602716112864265 4.987421635268882e-05 4.3021239150921975 0.3716448988910167 ANTIPIIGS(ph)PSSK ddPTM_A459_Selumetinib_30min_R2 1 ANTIPIIGSPSSK 13 0 E9PGM7;O94988-6;O94988-5;O94988-1;O94988 E9PGM7 FAM13A Protein FAM13A 1 ANTIPIIGS(0.876)PS(0.101)S(0.022)K 127.57 0.0019137 8071100.0 163880.0 137180.0 160740.0 178210.0 191640.0 137940.0 156360.0 183110.0 121320.0 139980.0 True False 154772.20566361846 147701.26489677798 150398.16340047962 153937.49057060265 167564.46991666264 156939.9829053526 163631.04982146225 183642.81978450753 145587.38996402555 135938.41368828207 1.1385465039964628 1.086530737628505 1.106369857642704 1.132406112400237 1.2326498843873646 1.1544932638777796 1.2037145747241222 1.3509266056731806 1.0709804978147632 1.0 17.05259366716185 -6.059373557943839 6.086565372703158 1.1873205186793532 1.1096604085380015 0.058544023092371056 0.08954542285642113 0.4353785420441052 33.82082275993996 0.025331477447493977 0.03334426020153177 8.722208058238002e-07 6.059373557943839 -0.07766011014135166 ANTLS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 ANTLSPVR 8 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 ANT(0.001)LS(0.999)PVR;ANT(0.002)LS(0.998)PVR 115.23 0.0067013 0.0 10337.1 12187.2 12159.5 12801.9 12213.400000000001 10401.3 11687.400000000001 10502.2 6021.3 9543.2 True False 10577.934317504809 10760.316958324436 10508.306687352497 10566.288486425505 11108.70012645091 10296.672365624781 10805.810008420278 10223.647540046633 10217.706321647991 10768.162678639856 0.9823341858019669 0.9992713965650813 0.9758681216989024 0.9812526799381666 1.0316244709495854 0.956214414001161 1.0034961702292167 0.949432864747359 0.9488811254603563 1.0 13.394484490105688 -7.763028581259452 24.999719738290846 0.9618677457518685 0.989785207836892 0.17900622685499978 0.02292347360928886 61.497745805375075 967361.5491596973 0.011182706898735243 0.005822991078659282 1.7257243169862768e-08 7.763028581259452 0.027917462085023437 ANVS(ph)SPHREFPPATAR ddPTM_A459_Selumetinib_30min_R1 1 ANVSSPHREFPPATAR 16 1 Q5QPM7;H0Y555;Q5QPM9;Q92530 Q5QPM7;Q92530 PSMF1 Proteasome inhibitor PI31 subunit 1 ANVS(0.695)S(0.305)PHREFPPATAR 83.891 0.0097867 65476000.0 534.76 428.73 794.27 976.86 765.59 805.62 471.57 539.33 333.77 316.35 True False 547.2188675381755 378.53409228883027 686.4124966128107 806.2697389332532 696.3425196758928 797.516194244434 435.9990952368149 525.0252164092618 566.3833124037086 356.9566040099462 1.5330123084735752 1.0604484915995078 1.9229578298926349 2.2587332182003483 1.9507764020986988 2.2342105042612186 1.221434455446204 1.4708376606883915 1.5867007530918995 1.0 8.479604883118354 -8.438161044864517 0.8326984988529667 1.0405948297135825 1.7802434681145698 0.26762211279802006 0.3704255300343134 0.9469227521344444 1.4707905963952275 0.3930347383755452 0.1439162860132718 3.6461871412283317e-09 8.438161044864517 0.7396486384009873 ANVS(ph)SPHREFPPATAR ddPTM_A459_Selumetinib_30min_R2 2 ANVSSPHREFPPATAR 16 1 Q5QPM7;H0Y555;Q5QPM9;Q92530 Q5QPM7;Q92530 PSMF1 Proteasome inhibitor PI31 subunit 1 ANVS(0.5)S(0.5)PHREFPPATAR;ANVS(0.5)S(0.5)PHREFPPATAR 73.593 0.018855 27852400.0 55345.0 51967.5 61874.0 65704.9 78438.0 45132.2 40266.2 47464.7 36002.3 54834.0 True False 52269.14646358899 55953.240148150675 57893.094203317545 56755.77927272537 68583.91719538295 51348.75088067971 42138.65808596161 47602.81441879594 43203.765988310464 53250.799944158134 0.9815654697845185 1.0507492884017982 1.0871779252899034 1.0658202192688704 1.2879415382924577 0.9642813053423982 0.7913244144717195 0.8939361374611274 0.8113261403324725 1.0 15.700515577503916 -6.99501056616882 24.98712199569184 0.8670929777834421 1.0937866994951995 0.5756270364784146 0.08955633512728946 94.79724894575553 474741.55959939584 0.031367802622030434 0.02756966447987228 1.0115548433341055e-07 6.99501056616882 0.2266937217117574 ANVSS(ph)PHR ddPTM_A459_Selumetinib_30min_R2 3 ANVSSPHR 8 0 Q5QPM7;H0Y555;Q5QPM9;Q92530 Q5QPM7;Q92530 PSMF1 Proteasome inhibitor PI31 subunit 1 ANVS(0.205)S(0.795)PHR;ANVS(0.031)S(0.969)PHR;ANVS(0.192)S(0.808)PHR 94.409 0.015029 36671600.0 28873.7 18842.12 30131.4 25208.44 27378.99 44890.5 103052.1 312144.0 84195.7 124145.2 True False 27269.01534457907 20287.25001703513 28192.77852858782 21775.00698501548 23939.396504923872 51073.75889961389 107844.22684386236 313052.28736177896 101037.19262441556 120560.80550803315 0.2261847474365298 0.16827400855150523 0.23384696551906575 0.18061431236509595 0.1985669920173912 0.4236348511806415 0.894521452385921 2.5966340059076645 0.8380600328494263 1.0 16.879401435657073 -7.421346523782906 3.4265529106805266 1.5656968151407527 0.229967578794757 0.5977105455653262 0.45119603659188184 0.1473375448301814 3.2271482554251048 0.196100278298857 0.12248956414623481 3.7901245007112005e-08 7.421346523782906 -1.3357292363459956 ANVSS(ph)PHREFPPATAR ddPTM_A459_Selumetinib_30min_R1 3 ANVSSPHREFPPATAR 16 1 Q5QPM7;H0Y555;Q5QPM9;Q92530 Q5QPM7;Q92530 PSMF1 Proteasome inhibitor PI31 subunit 1 ANVS(0.038)S(0.962)PHREFPPATAR;ANVS(0.267)S(0.733)PHREFPPATAR;ANVS(0.07)S(0.91)PHREFPPAT(0.02)AR 180.39 4.8327e-06 89825500.0 3983.3 3905.8 6672.9 7319.4 5427.1 4595.4 4176.299999999999 4196.95 2824.3599999999997 3168.52 True False 4076.103139847433 3448.5071202428417 5766.756831615976 6041.204192154504 4936.219763232327 4549.174448289356 3861.2783286415797 4085.633252385092 4792.7326369072625 3575.2304059984035 1.1400952321866253 0.9645552114507222 1.6129748790289715 1.6897384241359021 1.3806717896979452 1.2724143430467871 1.0800082484651212 1.1427608261359468 1.3405381171703434 1.0 11.803820504141955 -7.011314126331443 4.152118265015857 1.1535170219883952 1.3667129899087977 0.1889569626364751 0.2104002525505673 0.4262577166610587 17.23898990586984 0.08977766757399067 0.07318333638365193 9.742846801491167e-08 7.011314126331443 0.21319596792040252 ANVVT(ph)TPSTNR ddPTM_A459_Selumetinib_30min_R1 2 ANVVTTPSTNR 11 0 Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;E9PDP5 Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 ANVVT(0.726)T(0.218)PS(0.043)T(0.013)NR;ANVVT(0.771)T(0.225)PS(0.004)TNR 124.39 0.0083911 13887000.0 9450.3 11364.7 8700.3 8908.9 10102.3 8027.6 10117.2 9509.5 5253.4 9650.2 True False 9670.47360291723 10034.115640694312 7518.847047327021 7353.12785576486 9188.548748705924 7946.849632477626 9354.051458595546 9257.277168790682 8914.636106844953 10888.897170908125 0.8881040431490016 0.9214997150953419 0.690505836294894 0.6752867384412645 0.8438456718330463 0.7298121662595207 0.8590448887318701 0.8501574607135933 0.8186904483460633 1.0 13.410570224639185 -9.220514875890895 0.6629170761128829 1.005030756064256 0.7948776175945947 0.35490297479221344 0.0785298650028713 3.027168194824947 1.9084473519283025 0.12490390422565822 0.032570891470633384 6.018456475247606e-10 9.220514875890895 -0.21015313846966122 ANVVT(ph)TPSTNR ddPTM_A459_Selumetinib_30min_R2 1 ANVVTTPSTNR 11 0 Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;E9PDP5 Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 ANVVT(0.482)T(0.482)PS(0.028)T(0.007)NR 100.04 0.038967 17219000.0 42637.0 34604.0 41380.0 48796.0 51915.0 42350.0 45813.0 41832.0 38819.0 40132.0 True False 40267.40622943434 37258.015530602905 38717.65585113747 42149.9006222049 45392.973574011376 48183.32808497672 47943.39527673728 41953.7241943396 46583.88469348415 38973.28488454163 1.033205344346173 0.9559885865658948 0.993440916408215 1.0815075184725638 1.1647202361435038 1.2363168315865558 1.230160491186966 1.0764739056157961 1.1952773504078222 1.0 15.250197914518402 -5.974102000123299 2.68234860639708 1.1621690667488194 0.9894192808322781 0.4999453353419985 0.0693339116404505 0.20673272254995329 3.0153463050936815 0.02081923091554191 0.031895494315080423 1.0614462324520908e-06 5.974102000123299 -0.17274978591654122 ANVVTT(ph)PSTNR ddPTM_A459_Selumetinib_30min_R2 1 ANVVTTPSTNR 11 0 Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;E9PDP5 Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 ANVVT(0.152)T(0.573)PS(0.245)T(0.03)NR 112.84 0.017396000000000002 19421000.0 51588.0 36817.0 50446.0 55723.0 55998.0 43382.0 51767.0 47521.0 40607.0 40313.0 True False 48720.94548312637 39640.74551468635 47200.359281451936 48133.43127246341 48963.030611528266 49357.47671741344 54174.268074364474 47659.27824247497 48729.53465437828 39149.05894424713 1.2444985089554959 1.0125593458361142 1.2056575701773777 1.2294913995509082 1.2506821857776296 1.2607576797108788 1.383794899170246 1.2173799199195923 1.2447179055766033 1.0 15.256690008322847 -5.505686766047076 20.116574504297827 1.242624611870543 1.1236735964622881 0.10959909106106602 0.10341599429198885 89.08793371874046 104238.63229157537 0.02571918178557011 0.051210993318106725 3.1211398878562165e-06 5.505686766047076 -0.11895101540825492 ANVVTT(ph)PSTNRK ddPTM_A459_Selumetinib_30min_R1 1 ANVVTTPSTNRK 12 1 Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;E9PDP5 Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 ANVVT(0.011)T(0.989)PSTNRK 91.207 0.028167 0.0 3882.9 3894.9 4073.8 4924.2 4842.6 3477.2 4007.9 3557.9 2608.6 3544.6 True False 3973.3640151918253 3438.8832973101134 3520.6003357816207 4064.280908682025 4404.587685030469 3442.222525044991 3705.580876221199 3463.5329343120407 4426.603675394175 3999.5839373278186 0.993444337574395 0.8598102580659134 0.8802416428679294 1.016175925388237 1.1012614697050813 0.8606451518416666 0.9264915886968365 0.8659733083701897 1.1067660398575496 1.0 11.965634213968636 -5.756294304915905 0.00968477315683757 1.8861798290686917 2.8909323300008876e-05 0.049329666002907335 0.08914520020804181 17590.395308615727 38.06933132585086 3528.1712026541973 3889.1614531271275 1.7526923660991662e-06 5.756294304915905 -1.8861509197453918 APAASEGNHTDGAEEAAGSCAQAPS(ph)HSPPNKPK ddPTM_A459_Selumetinib_30min_R2 2 APAASEGNHTDGAEEAAGSCAQAPSHSPPNKPK 33 1 Q92560;F8W6N3 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 APAASEGNHTDGAEEAAGS(0.001)CAQAPS(0.499)HS(0.499)PPNKPK;APAASEGNHTDGAEEAAGS(0.006)CAQAPS(0.497)HS(0.497)PPNKPK 97.784 2.9404e-11 11004900.0 40877.0 33734.0 51395.0 50256.0 54530.0 35473.0 40486.0 49420.0 35963.0 49975.0 True False 38605.21998359611 36321.289328093815 48088.30165464498 43411.046103564426 47679.4538956148 40359.08375816715 42368.67922148707 49563.804018078554 43156.60489017672 48532.09189935632 0.7954575719434037 0.7483973574313525 0.9908557363315051 0.8944812474514454 0.9824314598779365 0.831595799370487 0.87300335846535 1.0212583484112276 0.8892385059286741 1.0 15.566651426088486 -5.253180924548504 24.96046922301362 0.9304058426740972 0.7719274469623738 0.5374585053653294 0.06050579645834951 452.41606776531205 1367381.2497194146 0.015144168566277531 0.038658557223457124 5.582375877652287e-06 5.253180924548504 -0.1584783957117234 APACS(ph)PEAAAAQLR ddPTM_A459_Selumetinib_30min_R2 1 APACSPEAAAAQLR 14 0 A0A0C3SFZ9;M0QZI3;O14526-3;O14526-2;O14526 A0A0C3SFZ9 FCHO1 F-BAR domain only protein 1 1 APACS(1)PEAAAAQLR 90.444 0.027265 0.0 7494.1 8855.4 7055.1 10006.0 10062.0 6496.2 7404.1 10380.0 4886.7 7365.2 True False 7077.607923259231 9534.580705401137 6601.182547012082 8643.165538687235 8797.92160457869 7390.9925833677835 7748.405320945821 10410.204081498496 5864.176545806153 7152.547538912241 0.9895226679381978 1.333032832501964 0.9229134809799515 1.2084037878344094 1.230040283789107 1.0333370792935415 1.083307070493683 1.4554540217822416 0.8198724320115426 1.0 12.804241466015162 -8.308715740296977 24.999838239636727 0.909936091912879 1.152636006686532 0.282240751404476 0.15747492968142807 588.7805217830615 311343.29930593085 0.1423332274498387 0.03675072429786721 4.912292963209929e-09 8.308715740296977 0.24269991477365294 APAGPSLEETSVS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 3 APAGPSLEETSVSSPK 16 0 A0A087WXZ7;K7EIX2;Q6AI08 A0A087WXZ7 HEATR6 HEAT repeat-containing protein 6 1 APAGPSLEETS(0.001)VS(0.5)S(0.5)PK;APAGPSLEETSVS(0.5)S(0.5)PK;APAGPSLEETS(0.014)VS(0.493)S(0.493)PK 204.67 2.1505e-07 45922000.0 13325.7 16431.6 14552.5 13753.140000000001 11317.25 12763.810000000001 13053.49 13707.09 8497.53 14714.2 True False 13636.162882701521 14507.780633156397 12576.35043116059 11351.412277411788 10293.606735722773 12635.417660012228 12068.854739874914 13343.533446296762 14419.687774964454 16602.91089844525 0.8213115739829968 0.8738094615995893 0.7574786438405978 0.6837001262516424 0.61998807309667 0.7610362867872433 0.7269119742734438 0.8036863853522392 0.8685035933255992 1.0 14.019148583205311 -8.487370912921307 1.4964341526997482 0.9980278790476619 0.747334099041301 0.5852332246125247 0.06583799995963875 0.3246635952542383 1.6005131702535178 0.07132424842625378 0.0211367795260328 3.2555853617868085e-09 8.487370912921307 -0.2506937800063609 APAGPSLEETSVSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 APAGPSLEETSVSSPK 16 0 A0A087WXZ7;K7EIX2;Q6AI08 A0A087WXZ7 HEATR6 HEAT repeat-containing protein 6 1 APAGPSLEETSVS(0.3)S(0.7)PK;APAGPSLEETSVS(0.29)S(0.71)PK 172.85 5.5724e-06 27474000.0 123072.0 112460.0 118111.0 125750.0 122079.0 107009.0 115399.0 127510.0 86115.0 111533.0 True False 116232.15093625108 121085.320384106 110511.86684953337 108622.63306915066 106742.34461989281 121748.5184190146 120765.28215878033 127881.03298958315 103340.40625413794 108312.75249246445 1.0731160298445708 1.1179230293545552 1.0203033743161676 1.002860979612791 0.9855011728865362 1.1240460205965581 1.1149682690150657 1.1806646036299382 0.9540926980073519 1.0 16.724843586953952 -6.777182100779943 24.998262660578472 1.088559216007617 1.0411222689903672 0.041115806543568945 0.06948176803316712 619.1602543435104 983174.295161471 0.024703466608854648 0.021862062570063175 1.6703900686499027e-07 6.777182100779943 -0.047436947017249764 APAPAAPRS(ph)PNLAGK ddPTM_A459_Selumetinib_30min_R1 2 APAPAAPRSPNLAGK 15 1 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 APAPAAPRS(1)PNLAGK;APAPAAPRS(1)PNLAGK 134.21 0.0022363 24539000.0 2446.0 1589.72 6277.6 7170.299999999999 3820.4 3268.2 2013.1599999999999 1804.69 1719.83 1292.2 True False 2502.9870409125156 1403.594843359222 5425.136400388505 5918.141708200869 3474.845494546402 3235.324875288175 1861.305720395586 1756.8237587407175 2918.425898586658 1458.0664570938916 1.7166481189761962 0.9626411996040029 3.7207744365791657 4.058897095813084 2.383187321565714 2.2189145491602495 1.2765575336705848 1.2048996465101367 2.001572619950016 1.0 10.509840762306885 -7.07608411400311 2.803502527723414 1.3862467965994942 2.6189140872737973 0.29885850766470323 0.8652312034449382 0.4025342650870317 6.194944499279202 0.40330816436485056 0.30905767304632337 8.392974159471079e-08 7.07608411400311 1.232667290674303 APAPLGTVADSLRAS(ph)DGQLQAK ddPTM_A459_Selumetinib_30min_R2 2 APAPLGTVADSLRASDGQLQAK 22 1 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 APAPLGT(0.014)VADS(0.225)LRAS(0.761)DGQLQAK;APAPLGT(0.013)VADS(0.067)LRAS(0.921)DGQLQAK 61.767 0.0067917 12013200.0 28221.0 24537.0 26111.0 30975.0 29215.0 21923.0 20648.5 24273.3 18526.3 27600.0 True False 26652.589797613953 26418.909001109772 24431.04668750726 26756.151565144603 25544.750514586223 24942.694252820416 21608.696164226538 24343.931284338858 22232.0776680722 26803.11628658797 0.9943839929893026 0.9856655740560119 0.9115002310284468 0.9982477887667537 0.9530515124231498 0.9305893384233649 0.8062008884780061 0.9082500342141311 0.8294586879510322 1.0 14.710113126122026 -6.998434023873735 4.624537773797409 0.8767395202852731 0.966605804514527 0.3370762748355205 0.05373322401259428 0.1978383900114565 11.133796252911859 0.01896059820019143 0.01571785761182697 1.0036123019775774e-07 6.998434023873735 0.08986628422925391 APAPQPPSLPDRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 APAPQPPSLPDRSPR 15 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 APAPQPPS(0.003)LPDRS(0.997)PR;APAPQPPS(0.004)LPDRS(0.996)PR 86.22200000000002 0.01095 7025000.0 53026.0 41914.0 54426.0 60553.0 62895.0 54749.0 55392.0 72195.0 53783.0 53019.0 True False 50079.027199896445 45128.66902524821 50924.29041454825 52305.57694024862 54993.56781156598 62290.177788061155 57967.8377571657 72405.07549747443 64541.10282257805 51488.203710094494 0.9726310803512889 0.8764855981254698 0.9890477186051903 1.0158749610834428 1.068080916576708 1.2097951239236744 1.125846962608269 1.406245902559601 1.2535124197763472 1.0 15.65195431867407 -6.453168341825744 1.1204415738963258 1.2343567790106624 0.9324315660745103 0.5416478974132317 0.1017741884074569 0.33375879234078476 0.8830162789963442 0.04568768644791833 0.05606627987803714 3.522343110282155e-07 6.453168341825744 -0.30192521293615215 APAPVVLGS(ph)PVVLGPPVGQAR ddPTM_A459_Selumetinib_30min_R1 2 APAPVVLGSPVVLGPPVGQAR 21 0 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 APAPVVLGS(1)PVVLGPPVGQAR;APAPVVLGS(1)PVVLGPPVGQAR 192.22 1.6463e-16 22070600.0 883.21 1049.76 938.7900000000001 923.25 853.01 953.72 650.9200000000001 804.38 545.46 630.8199999999999 True False 903.7870745725033 926.8536111798164 811.3074744043472 762.0217190489179 775.8553961111473 944.1264427084755 601.8205803413016 783.0452294055256 925.6057811778368 711.7918917071419 1.2697349957230977 1.3021412887366228 1.139809941440229 1.0705681364553146 1.090003138769054 1.3264079764158438 0.8455007528926916 1.1001041716385553 1.3003882061059864 1.0 9.47531168842669 -5.335770611093132 4.286737135758474 1.1068110029168141 1.2867015686239638 0.2321600643869206 0.12956748034566673 0.3078754614027773 10.684886760630226 0.03422460921563074 0.07778528483140763 4.6156130108737465e-06 5.335770611093132 0.17989056570714967 APAPVVLGS(ph)PVVLGPPVGQAR ddPTM_A459_Selumetinib_30min_R2 2 APAPVVLGSPVVLGPPVGQAR 21 0 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 APAPVVLGS(1)PVVLGPPVGQAR;APAPVVLGS(1)PVVLGPPVGQAR 190.96 1.3817999999999998e-16 19886600.0 20235.9 17048.300000000003 23103.0 25417.0 24346.0 21908.3 20989.0 21411.1 15631.4 23033.0 True False 19111.269688726003 18355.849791075518 21616.5781326445 21955.160753229393 21287.437823998476 24925.969461253717 21965.030088914496 21473.40275620159 18758.116777807976 22367.977443079024 0.854403118804973 0.8206307359611131 0.9664073646199506 0.9815442996176053 0.9516925648807428 1.11435955819806 0.9819855257280222 0.9600064561423175 0.838614793203487 1.0 14.449147190494605 -5.292187664292676 6.535547223407177 0.9779851587657296 0.8373104056034367 0.425997651549914 0.06343040110835738 0.16465829061277082 24.972959983010433 0.01733065289961835 0.03787760550527213 5.102844517812237e-06 5.292187664292676 -0.14067475316229283 APAVPPARPGS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 APAVPPARPGSR 12 1 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 1 APAVPPARPGS(1)R;APAVPPARPGS(1)R 108.31 0.0044616000000000005 11432200.0 38509.0 34900.0 40313.0 41647.0 43149.0 33327.0 38126.0 37778.0 35045.0 37862.0 True False 36368.82394374105 37576.71777881286 37719.305469475694 35974.60675491776 37728.23686304571 37917.49173761555 39898.93454523577 37887.927725515445 42054.97923911364 36768.825682709925 0.9891211717659787 1.0219722028403762 1.0258501534688045 0.9783996656666237 1.0260930601541332 1.031240215959515 1.0851294215794804 1.0304361649312006 1.1437672663799394 1.0 15.166195480246634 -6.94507975224891 2.158854608797946 1.0675307656138073 1.0071851689120845 0.3319815115743776 0.037643174865813624 0.34870028129658964 3.292647440502376 0.014952843705725905 0.01217370242610188 1.1348024055772819e-07 6.94507975224891 -0.06034559670172279 APDSGLPSGGGGRPGCAYPGS(ph)PGPGAR ddPTM_A459_Selumetinib_30min_R1 2 APDSGLPSGGGGRPGCAYPGSPGPGAR 27 1 Q6PJ61 Q6PJ61 FBXO46 F-box only protein 46 1 APDS(0.001)GLPS(0.009)GGGGRPGCAY(0.387)PGS(0.604)PGPGAR;APDSGLPSGGGGRPGCAY(0.012)PGS(0.988)PGPGAR 59.56100000000001 0.0030868 18130500.0 1418.3899999999999 1675.65 1742.78 1952.96 1786.9099999999999 1593.57 1645.98 1630.56 926.75 1389.4699999999998 True False 1451.4357272935006 1479.4641190114487 1506.120048405296 1611.9121975995401 1625.2843060045832 1577.5401326457918 1521.8224034138996 1587.3122519946717 1572.6270628580653 1567.8220090839268 0.9257656282944833 0.9436429074470607 0.9606447923800464 1.0281219349263857 1.0366510334640802 1.0061984865026505 0.9706601862944221 1.0124314130034013 1.0030647954591134 1.0 10.61454606784763 -5.581934868340558 4.084399732349578 1.008082276350352 0.9376068713896414 0.7559090591159369 0.01722845470087014 0.11132326572993474 3.7775650472910036 0.005308056289570484 0.009905941704058901 2.6185756896801416e-06 5.581934868340558 -0.0704754049607107 APDSGLPSGGGGRPGCAYPGS(ph)PGPGAR ddPTM_A459_Selumetinib_30min_R2 1 APDSGLPSGGGGRPGCAYPGSPGPGAR 27 1 Q6PJ61 Q6PJ61 FBXO46 F-box only protein 46 1 APDSGLPS(0.002)GGGGRPGCAY(0.016)PGS(0.982)PGPGAR 52.91 0.0088098 7997400.0 15554.0 16104.0 15333.0 12962.0 14224.0 13179.0 13442.0 10892.0 8093.7 12532.0 True False 14689.570947595315 17339.12501747858 14346.491473308142 11196.553239302812 12437.053955826597 14994.287622949423 14067.07963481769 10923.693916732334 9712.666156872992 12170.16859795364 1.207014580723664 1.424723484964216 1.178824381752644 0.9199998462786673 1.0219294708799542 1.2320525802305358 1.1558656333802153 0.8975795058886124 0.7980716190329635 1.0 13.571061533940187 -4.497103816230608 0.3155911711752721 0.927926808009796 1.7130019007792225 0.4128798195929817 0.13741354310138132 9.564410737727398 0.67403915179876 0.16150454234285186 2.989409128727141 3.18343644395447e-05 4.497103816230608 0.7850750927694266 APDVDVNIAGPDAALKVDVKS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 APDVDVNIAGPDAALKVDVKSPK 23 2 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 APDVDVNIAGPDAALKVDVKS(1)PK 69.255 0.0011286 25626000.0 2780.6 2871.2 5118.9 4522.8 2820.7 3526.2 2616.6 2579.0 2430.3 2003.5 True False 2845.382569894253 2535.038569215332 4423.781496104998 3732.9778834708327 2565.5681830350313 3490.7296295334318 2419.2277553632553 2510.596542227368 4124.041597910932 2260.66874074262 1.2586463990118062 1.121366666211602 1.9568464040652878 1.6512715092634782 1.1348713488170112 1.5441137246789824 1.0701381019532077 1.1105548092829594 1.824257364020614 1.0 11.142533891921667 -6.260509278499738 24.986384583552134 1.2888306383321442 1.503043278715287 0.10318137858285537 0.31175348020117766 218.56064930835322 5871427.442681592 0.09634078152720851 0.11723228073184369 5.488968285561689e-07 6.260509278499738 0.2142126403831428 APDWVDAEECHR ddPTM_A459_Selumetinib_30min_R1 2 APDWVDAEECHR 12 0 I3L1P5;O14964-2;O14964 I3L1P5 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 0 ; 131.06 0.0029212 8835500.0 6609.1 8186.5 7408.5 8398.5 8287.9 6898.6 7798.8 7544.0 4483.4 6154.3 False True 6763.079170930054 7228.020774199404 6402.4663919775485 6931.859634370249 7538.260908347585 6829.206347427643 7210.530237150096 7343.908613634454 7608.002345419858 6944.264352958477 0.9739086571565738 1.0408619843396425 0.9219790702884021 0.9982136741981975 1.0855377222406644 0.9834312175224413 1.038343281686588 1.0575502659984015 1.095580749626648 1.0 12.761606153735231 -6.01703882672699 24.243846549252016 1.0429275471318569 0.9809419939387004 0.33712995828809733 0.041619602513644396 574.8161504287432 817884.1238609139 0.012063563572584514 0.015981416920518743 9.615263123167592e-07 6.01703882672699 -0.06198555319315646 APDWVDAEECHR ddPTM_A459_Selumetinib_30min_R2 1 APDWVDAEECHR 12 0 I3L1P5;O14964-2;O14964 I3L1P5 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 0 114.87 0.0075815 4283600.0 30374.0 30459.0 30904.0 35726.0 34813.0 22332.0 24563.0 29292.0 22192.0 29938.0 False True 28685.93467675583 32795.107358878566 28915.670285731077 30860.057169212472 30439.479707831237 25408.03029028806 25705.22817066114 29377.234870448337 26631.020096287903 29073.612151734455 0.9866656584343444 1.1280025057678325 0.9945675182987554 1.0614455819302606 1.0469796304968353 0.8739206589702093 0.8841429140798259 1.0104432403214738 0.9159859448252001 1.0 14.827422704881696 -6.740606220097255 24.792878310725026 0.9342540359874568 1.0464999551930845 0.4878848091959985 0.0545487716034395 178.99419943363125 213014.75497344657 0.017574642177384223 0.017555742189070096 1.817162558644876e-07 6.740606220097255 0.11224591920562765 APEAAVSEDGKS(ph)DDELLSSK ddPTM_A459_Selumetinib_30min_R2 2 APEAAVSEDGKSDDELLSSK 20 1 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 APEAAVS(0.029)EDGKS(0.965)DDELLS(0.005)S(0.001)K;APEAAVS(0.009)EDGKS(0.888)DDELLS(0.052)S(0.051)K 65.21300000000001 0.0094176 15621500.0 82085.0 74627.0 57278.0 60971.0 57231.0 38457.0 55450.0 51461.0 33937.0 43240.0 True False 77523.04431229018 80350.65093637432 53592.795839571096 52666.64461915845 50041.13012836844 43754.10267211215 58028.53487209053 51610.742990172854 40725.348279006954 41991.54884898785 1.8461582493916218 1.9134957661441696 1.2762757580651345 1.2542201005388234 1.1916952696441112 1.0419740131392365 1.3819098476404315 1.229074525823709 0.9698462999177652 1.0 15.357811382191146 -5.316854391802093 3.7709953418858735 1.1743586168516598 1.8909855231793333 0.846220561151071 0.12183590565789389 0.07806339084810109 2.2555925375301444 0.03255974364004384 0.0789351717447292 4.8210940989191865e-06 5.316854391802093 0.7166269063276736 APELPNT(ph)SSSPSLK ddPTM_A459_Selumetinib_30min_R2 1 APELPNTSSSPSLK 14 0 Q9UN79 Q9UN79 SOX13 Transcription factor SOX-13 1 APELPNT(0.693)S(0.18)S(0.063)S(0.063)PSLK 202.92 9.6788e-05 4650500.0 34133.0 29198.0 32494.0 36476.0 36145.0 27528.0 28858.0 22423.0 23013.0 33758.0 True False 32236.024505225076 31437.392713632635 30403.37141679217 31507.905875390294 31604.14195960014 31319.732125696333 30199.954181042165 22488.247217672528 27616.243036944557 32783.31882618251 0.9833057072757277 0.9589447877536136 0.9274037072936744 0.9610956731515051 0.9640311930334332 0.9553557494210354 0.92119880666026 0.6859661566574586 0.8423870439526321 1.0 15.000674292916262 -7.541672273994793 24.998030800841853 0.8192223926331876 0.9557683630470076 0.3220660398930101 0.07255628323038393 222.31206801083334 295702.6704279575 0.031847534827684 0.018390615926757874 2.8729477394799557e-08 7.541672273994793 0.13654597041382 APELPNTSSS(ph)PSLK ddPTM_A459_Selumetinib_30min_R1 1 APELPNTSSSPSLK 14 0 Q9UN79 Q9UN79 SOX13 Transcription factor SOX-13 1 APELPNT(0.011)S(0.004)S(0.232)S(0.747)PS(0.006)LK 113.43 0.0032969 3983100.0 1826.3 1753.4 1770.5 1870.3 2236.7 1777.5 1741.0 1559.1 903.67 1492.3 True False 1868.8492366388084 1548.111112866455 1530.0758246603564 1543.6872148791674 2034.3908799214582 1759.619963840871 1609.674968312858 1517.7476033294638 1533.461988554571 1683.8512412329471 1.1098659969929423 0.9193871019941757 0.9086763647482342 0.9167598521047804 1.2081773200059167 1.0449972781161148 0.9559484406319789 0.90135492148234 0.9106873285503188 1.0 10.717548974720087 -7.456939053265418 5.451808585538781 0.9291439390876282 1.0121911533553705 0.14065101549661507 0.09144452407175566 0.4639449370918494 26.870616926696083 0.04285285410835657 0.028008482353544667 3.491893155377348e-08 7.456939053265418 0.08304721426774231 APELPNTSSS(ph)PSLK ddPTM_A459_Selumetinib_30min_R2 1 APELPNTSSSPSLK 14 0 Q9UN79 Q9UN79 SOX13 Transcription factor SOX-13 1 APELPNTSS(0.032)S(0.96)PS(0.009)LK 128.35 0.0011413 5537700.0 35215.0 27949.0 35744.0 34594.0 34622.0 30911.0 28866.0 30762.0 25246.0 31685.0 True False 33257.89127681426 30092.59842980062 33444.269955124626 29882.237522021387 30272.47483539292 35168.70966787991 30208.326196893868 30851.512327076765 30295.90543217755 30770.171722483316 1.0808484130919946 0.9779795413950322 1.0869055349043564 0.9711430209597066 0.9838253458063501 1.1429481117319424 0.9817405788093501 1.002643488808807 0.9845868169153172 1.0 14.909244874650344 APEPDLMS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 APEPDLMSPTR 11 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 APEPDLMS(0.946)PT(0.054)R;APEPDLMS(0.696)PT(0.304)R 120.59 0.0046868000000000005 17742700.0 43737.0 33338.0 45046.0 43951.0 49780.0 42884.0 49349.0 47197.0 52808.0 58379.0 True False 41306.272633083216 35894.91740143448 42147.78940237649 37964.79798029607 43526.191361153586 48790.88173780737 51643.82628318839 47334.33545611604 63371.07557880192 56693.44658314202 0.7285899009951138 0.6331405050281059 0.7434331821856334 0.6696505551945933 0.7677464325144107 0.8606088477308328 0.9109311462913396 0.8349172313364179 1.1177848481282053 1.0 15.790894357601841 -7.216178924492977 0.6842115705652063 1.0299400200346887 0.6757782433526618 0.7955720923325366 0.0647740211959032 0.3090185860618627 0.2908037828558189 0.0530564253918644 0.03660414133128245 6.078845080303098e-08 7.216178924492977 -0.35416177668202686 APEPDLMS(ph)PTRK ddPTM_A459_Selumetinib_30min_R1 2 APEPDLMSPTRK 12 1 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 APEPDLMS(0.991)PT(0.009)RK;APEPDLMS(0.68)PT(0.32)RK 133.88 0.0030157 7050000.0 2109.0 2620.7 2412.0 2504.6 2035.47 1988.9 2478.0 2478.2 1692.8899999999999 1979.55 True False 2158.1355966003666 2313.8672256696223 2084.463648167624 2067.2186271648197 1851.3620978914162 1968.8934717767124 2291.0824649507554 2412.4700856719114 2872.710686206409 2233.6445249498643 0.9661947424910002 1.0359156077986753 0.9332118987081935 0.925491323294256 0.8288526116003043 0.8814712680483058 1.0257148974956882 1.0800599910704507 1.2861091611123254 1.0 11.125183889955943 -7.670308280264982 2.519366520188254 1.1468895993225894 0.9302356637937558 0.5192630200911865 0.08336904723172568 0.22345986223507291 2.8458972098963944 0.05105119986816928 0.024419205982005802 2.1364450136999883e-08 7.670308280264982 -0.2166539355288336 APES(ph)DTGDEDQDQER ddPTM_A459_Selumetinib_30min_R1 1 APESDTGDEDQDQER 15 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 APES(0.79)DT(0.21)GDEDQDQER 287.43 4.7716999999999995e-67 1691100.0 220.06 361.5 403.7 339.21 121.37 275.86 145.72 207.32 197.29 166.87 True False 225.1869698377792 319.17541194320927 348.8797573653691 279.9733412603122 110.39210492961394 273.0850988608398 134.7282230801549 201.82120012973166 334.78672050851674 188.28938995144534 1.1959620767577437 1.695132221871428 1.8528912194964122 1.486931055077026 0.586289567128987 1.4503477807818113 0.7155380508423634 1.0718670881124837 1.7780434712484279 1.0 7.556807896600475 -6.021116190126312 24.51113573960941 1.0962377480310013 1.6055759758710797 0.28982699316794225 0.3524282475395578 710.1191329758859 824288.4399966359 0.10171981840515262 0.13283204999968734 9.525412892701496e-07 6.021116190126312 0.5093382278400784 APES(ph)DTGDEDQDQER ddPTM_A459_Selumetinib_30min_R2 2 APESDTGDEDQDQER 15 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 APES(0.993)DT(0.007)GDEDQDQER;APES(0.992)DT(0.008)GDEDQDQER 174.52 2.4978e-05 14885400.0 8379.5 3734.8999999999996 6601.6 7009.2 8018.2 4303.4 9625.1 6455.6 7147.4 5123.0 True False 7913.800935796257 4021.354820403674 6176.860243278616 6054.534868455584 7010.882032382512 4896.154287624294 10072.686221773825 6474.384727217887 8577.079715041824 4975.085678847473 1.5906863613310809 0.8082986062936025 1.241558566426447 1.2169709748311663 1.409198250030269 0.9841346669548283 2.024625679231973 1.3013614528780821 1.7240064329965044 1.0 12.280505656023697 -7.223042968406881 24.999822124512054 1.5376127042145666 1.2012986067430242 0.17745964304188755 0.318604375569093 831.0480347113091 541094.2160815983 0.1131720726100395 0.08766114403968361 5.98352392095463e-08 7.223042968406881 -0.3363140974715424 APES(ph)DTGDEDQDQERDTVFLK ddPTM_A459_Selumetinib_30min_R2 3 APESDTGDEDQDQERDTVFLK 21 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 APES(0.984)DT(0.016)GDEDQDQERDTVFLK;APES(0.95)DT(0.05)GDEDQDQERDTVFLK;APES(0.948)DT(0.052)GDEDQDQERDTVFLK 96.341 0.00021472 40907600.0 42471.9 38164.4 46813.4 49671.8 41143.5 31672.2 24851.8 26327.5 23735.1 39250.1 True False 40111.48182648668 41091.486762112516 43801.47681057607 42906.41515136565 35974.68570244318 36034.7580583943 26007.457942907466 26404.108666247757 28482.7832141043 38116.847628993 1.0523294637822171 1.0780400090288922 1.149136918060851 1.1256548697046378 0.9438001288196662 0.9453761341739344 0.6823087311954227 0.692714909775589 0.7472491820766234 1.0 15.21814118877432 -6.789588540752903 1.6934136144544312 0.7594179808339483 1.0989679055818 0.6754702982652181 0.09501836658790389 0.19099369464760554 1.1333865785326267 0.03990147058450487 0.035586497092792053 1.623347360667759e-07 6.789588540752903 0.33954992474785173 APES(ph)PPSADPALVAGPAEEAECPPPR ddPTM_A459_Selumetinib_30min_R1 1 APESPPSADPALVAGPAEEAECPPPR 26 0 Q6EEV4-2;Q6EEV4 Q6EEV4-2 POLR2M DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 1 APES(0.991)PPS(0.009)ADPALVAGPAEEAECPPPR 164.01 7.5796e-15 10160000.0 940.14 1039.9 814.59 782.5 665.89 651.99 1076.6 789.18 510.63 805.8 True False 962.0434328060068 918.1480245636053 703.9731522225808 645.8510643441948 605.6603670724279 645.4315725595551 995.3911952243676 768.2483827820839 866.5018150603872 909.2322791566766 1.058083236660178 1.009805795077137 0.7742500660837999 0.7103257101070247 0.666122816970582 0.7098643408900972 1.0947600718131174 0.8449418266305319 0.9530037977359072 1.0 9.828505092752104 -7.254454430811252 24.978003132733086 0.9602549102649683 0.8157209267491548 0.23633319490900384 0.1326056704170309 972.861633708425 3478937.9623276927 0.05767241433633136 0.04369746159214687 5.566030338445511e-08 7.254454430811252 -0.1445339835158136 APES(ph)PPSADPALVAGPAEEAECPPPR ddPTM_A459_Selumetinib_30min_R2 3 APESPPSADPALVAGPAEEAECPPPR 26 0 Q6EEV4-2;Q6EEV4 Q6EEV4-2 POLR2M DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 1 APES(0.99)PPS(0.01)ADPALVAGPAEEAECPPPR;APES(0.995)PPS(0.005)ADPALVAGPAEEAECPPPR;APES(0.968)PPS(0.032)ADPALVAGPAEEAECPPPR 185.21 5.6289e-23 13328500.0 45378.9 38869.9 47538.4 48329.5 51837.3 40608.6 41940.4 43784.4 37857.2 45938.8 True False 42856.9224041297 41851.09634357243 44479.83109989639 41746.93872696227 45325.034942658225 46202.06604183199 43890.71170332598 43911.8053551024 45429.697818546774 44612.42748066334 0.9606498642716866 0.9381039926982729 0.9970278151570116 0.9357692706826348 1.0159732949367921 1.0356321915425395 0.9838225396353925 0.984295359720907 1.0183193424800223 1.0 15.445158030665498 -6.271744313674875 24.969970206611837 1.0058939150739679 0.9592703308014175 0.552492826047225 0.021346140095471866 562.7530726710505 1363609.906557974 0.006687988764834278 0.00766744154530931 5.348791712237028e-07 6.271744313674875 -0.04662358427255031 APESDT(ph)GDEDQDQER ddPTM_A459_Selumetinib_30min_R1 1 APESDTGDEDQDQER 15 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 APES(0.226)DT(0.774)GDEDQDQER 218.34 6.703e-09 3399000.0 155.92 0.0 129.08 0.0 0.0 0.0 192.12 77.843 0.0 0.0 True False 159.55263263249353 0.0 111.55164498568695 0.0 0.0 0.0 177.62823372330064 75.7783507703005 0.0 0.0 0.0 APETDDS(ph)FSDVDCHSNQEDTGCK ddPTM_A459_Selumetinib_30min_R2 1 APETDDSFSDVDCHSNQEDTGCK 23 0 Q68D20 Q68D20 PMS2CL Protein PMS2CL 1 APET(0.003)DDS(0.776)FS(0.221)DVDCHSNQEDTGCK 112.55 8.784e-06 8149500.0 17890.0 14873.0 16258.0 18351.0 21313.0 19817.0 24077.0 19420.0 18745.0 21249.0 True False 16895.745419344228 16013.711275767455 15211.977980371996 15851.562142759276 18635.470399362523 22546.611869184966 25196.6282076704 19476.508984845936 22494.523779060775 20635.48615846768 0.8187713771120015 0.7760278169747069 0.7371756528318975 0.7681700358803836 0.9030788156021001 1.092613553954631 1.2210339031596344 0.9438357223706036 1.0900893541502654 1.0 14.332839807240088 -6.553870263497469 3.0164738681553094 1.075208113792089 0.7740414846752633 0.7973958134516426 0.06998975082568426 0.11317222721201113 2.111765550627487 0.02485515417990115 0.025954732027090473 2.793378180621483e-07 6.553870263497469 -0.3011666291168257 APETDDSFS(ph)DVDCHSNQEDTGCK ddPTM_A459_Selumetinib_30min_R1 2 APETDDSFSDVDCHSNQEDTGCK 23 0 Q68D20 Q68D20 PMS2CL Protein PMS2CL 1 APETDDS(0.025)FS(0.975)DVDCHSNQEDTGCK;APETDDS(0.025)FS(0.975)DVDCHSNQEDTGCK 130.15 5.2885e-06 8015700.0 3858.2 3175.2 2858.0 2770.6800000000003 2661.1099999999997 2598.4300000000003 2915.49 2644.71 1906.86 2785.88 True False 3948.08855324966 2803.446107889566 2469.8992978702613 2286.832750105016 2420.413070357129 2572.292153385672 2695.572242025534 2574.5636995712066 3235.8021484559263 3143.474834769176 1.255963149308802 0.8918303009400175 0.7857226247054161 0.7274856234924932 0.7699801008697621 0.8182957677708128 0.8575135427236428 0.8190183904431528 1.029371099989585 1.0 11.618144498263893 -4.766205569220346 3.859793318809373 0.8361680614771626 1.3039162487487308 0.6314980780602464 0.09167703188468151 0.1595973447691503 4.276175665806434 0.023047826549254347 0.2170368130756065 1.713146213866742e-05 4.766205569220346 0.4677481872715682 APETDDSFS(ph)DVDCHSNQEDTGCK ddPTM_A459_Selumetinib_30min_R2 1 APETDDSFSDVDCHSNQEDTGCK 23 0 Q68D20 Q68D20 PMS2CL Protein PMS2CL 1 APET(0.003)DDS(0.11)FS(0.887)DVDCHSNQEDTGCK 116.55 7.142999999999998e-06 7674900.0 34142.0 27269.0 30056.0 35058.0 37687.0 37089.0 43696.0 41633.0 35405.0 29923.0 True False 32244.524321254932 29360.444616345227 28122.229682498488 30283.039921576743 32952.42213394523 42197.67308957974 45727.95058198137 41754.145137285836 42486.98929835408 29059.045240709125 1.1096209133562047 1.0103719641557207 0.9677616538860595 1.04212095307085 1.1339815833928992 1.4521355653648444 1.5736219205826005 1.4368725741474813 1.4620917152100237 1.0 14.826699682343941 -6.648421687453355 3.6908505859322895 1.4245449808348776 1.0315413260243316 0.558823997966407 0.14729257970629497 0.15105791249254602 3.927549412728085 0.048550696142114 0.048110059105654406 2.2468718983319312e-07 6.648421687453355 -0.393003654810546 APEYLHR ddPTM_A459_Selumetinib_30min_R2 1 APEYLHR 7 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6R9X5;D6R9A4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 104.45 0.025267 3309100.0 22022.0 17420.0 18385.0 19989.0 24007.0 18507.0 13003.0 18438.0 16925.0 16229.0 False True 20798.1054010508 18756.057985871637 17202.12911607449 17266.46371705168 20991.026034696944 21056.171260180974 13607.665264955687 18491.651527424776 20310.472924011934 15760.426601994071 1.3196410177386533 1.1900729884747248 1.0914761097836025 1.0955581440204836 1.3318818433532171 1.3360153117629991 0.863407165846259 1.1732963830487393 1.2887007082309672 1.0 13.944018965628741 -14.522878745280316 0.1774744062704392 0.30360591380515456 1.2174980337716301 0.13704601927753757 0.13942338466136925 307.4468439164442 2.9368951477812226 76.09782756003199 0.4711320577258069 3.0000000000001485e-15 14.522878745280316 0.9138921199664756 APFHT(ph)PPEEPNECDFK ddPTM_A459_Selumetinib_30min_R2 2 APFHTPPEEPNECDFK 16 0 Q9UBU7 Q9UBU7 DBF4 Protein DBF4 homolog A 1 APFHT(1)PPEEPNECDFK;APFHT(1)PPEEPNECDFK 127.97 0.0013468 7188400.0 50617.0 54187.0 57398.0 58840.0 60493.0 47153.0 50170.0 47501.0 43526.0 57367.0 True False 47803.90977590537 58342.968661333325 53705.07517021723 50825.89049533848 52893.328525718425 53647.89773768373 52503.00440996905 47639.22004578611 52232.4162180528 55710.66565263375 0.8580746472133639 1.0472495343191996 0.96399988298611 0.9123188513353486 0.9494291246763782 0.9629735546903755 0.9424228519783796 0.855118485620427 0.9375658252538487 1.0 15.765665933526643 -7.538543708143526 24.976038853529477 0.9175594340284365 0.9525221191306974 0.0015794900675166756 0.05554819862982432 674.4223238076787 1075277.9370407367 0.025053005235287557 0.014470060192775983 2.8937185735960173e-08 7.538543708143526 0.03496268510226086 APGAPPRS(ph)PPQR ddPTM_A459_Selumetinib_30min_R1 1 APGAPPRSPPQR 12 1 H3BN50;Q15599-3 H3BN50 SLC9A3R2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 1 APGAPPRS(1)PPQR 72.848 0.030797 3889500.0 1400.6 1691.4 1608.7 1869.5 1774.4 1210.4 1388.3 1746.2 1198.3 1268.5 True False 1433.231254906814 1493.3701016894727 1390.2473759565746 1543.0269198613064 1613.905833295764 1198.2244749552679 1283.579413273258 1699.8851035430132 2033.4275796307734 1431.3243312363418 1.0013322792248107 1.043348505366032 0.971301434354654 1.0780414237271287 1.1275612368733459 0.8371439294406963 0.8967774705293625 1.1876309697570049 1.4206616454806926 1.0 10.483134901554807 -7.8938481301623 6.223609768513637 1.2398752334674845 0.9977853410539989 0.37088727240920516 0.12354528474937422 0.19896976865933924 10.143414786372349 0.06813275069694033 0.032237448177078125 1.2768852488680823e-08 7.8938481301623 -0.24208989241348566 APGASPGNPLS(ph)PSLSDKDR ddPTM_A459_Selumetinib_30min_R1 2 APGASPGNPLSPSLSDKDR 19 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 APGASPGNPLS(0.994)PS(0.005)LS(0.001)DKDR;APGASPGNPLS(0.993)PS(0.005)LS(0.002)DKDR 107.07 0.00043754 21918000.0 4237.4 4230.1 5623.200000000001 5525.0 5049.0 4301.4 4753.1 4608.9 2922.9300000000003 4643.7 True False 4336.123175454904 3734.8379254798624 4859.600326026613 4560.162467094799 4592.318841473351 4258.1318213587165 4394.569840257239 4486.657000182907 4959.998727639304 5239.764128468427 0.8275416734688675 0.7127874144540068 0.9274463901196761 0.8702991881483271 0.8764361770642675 0.8126571572608862 0.8386961192357648 0.8562707958181217 0.946607252927834 1.0 12.355286153991992 -14.52287874419353 0.09594109935696644 1.5091543782151462 0.7349272345420033 0.4805943444425407 0.05440563713080105 183.08737625311096 1.2011734408458543 18.54992502572142 1.0913334674840955 3.0000000075073986e-15 14.52287874419353 -0.7742271436731429 APGASPGNPLS(ph)PSLSDKDR ddPTM_A459_Selumetinib_30min_R2 4 APGASPGNPLSPSLSDKDR 19 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 APGASPGNPLS(0.929)PS(0.056)LS(0.015)DKDR;APGAS(0.002)PGNPLS(0.869)PS(0.118)LS(0.012)DKDR;APGASPGNPLS(0.885)PS(0.082)LS(0.033)DKDR;APGASPGNPLS(0.966)PS(0.026)LS(0.007)DKDR 76.889 0.0046349 50791800.0 145949.0 131019.0 157414.0 179185.0 155608.0 117805.0 133818.0 139489.0 130093.0 140181.0 True False 137837.73886013834 141067.7360075151 147286.15461940423 154779.69388863418 136059.13188682956 134031.56942268444 140040.8021553364 139894.88989635283 156115.23510212623 136133.61029602104 1.0125180589893392 1.0362447282545793 1.0819235183664937 1.1369689935649796 0.9994529021229253 0.9845589868015272 1.0287011550697818 1.027629323810284 1.146779511412761 1.0 17.05466377508531 -11.82553507686375 2.382319065427402 0.7432215963432139 1.0488179741743058 0.0766657030815826 0.052305435989205847 11531091.229027526 2101127.7802358954 16079176.33297218 0.013826848783496187 1.4943933391324863e-12 11.82553507686375 0.30559637783109184 APGLGVLS(ph)PSGEER ddPTM_A459_Selumetinib_30min_R1 1 APGLGVLSPSGEER 14 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 APGLGVLS(0.722)PS(0.278)GEER 153.0 0.00037177 15239000.0 626.22 553.23 740.16 618.85 598.4 602.71 665.37 497.77 298.35 302.84 True False 640.8097075879945 488.45757441035073 639.6503374078561 510.7794647532334 544.2748256561006 596.6472846168951 615.1806052075395 484.56752261516766 506.2781593781539 341.71246391140215 1.8752892424612906 1.4294403218988116 1.8718964186618083 1.4947639278550469 1.592785991549954 1.7460506935784217 1.8002872888096968 1.4180563303678744 1.481591141227496 1.0 8.416639060589103 -8.702627194022709 1.057458102075337 1.0041184644440675 1.6711974978114106 0.6317902232038426 0.1547167071847625 0.4717724344155903 1.0656728733022691 0.14054627243968276 0.045077574427096284 1.9832287335361528e-09 8.702627194022709 0.6670790333673431 APGLGVLS(ph)PSGEER ddPTM_A459_Selumetinib_30min_R2 1 APGLGVLSPSGEER 14 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 APGLGVLS(0.5)PS(0.5)GEER 132.51 0.00080221 9579400.0 6370.8 9228.3 11314.0 14780.0 14772.0 7430.6 9437.7 11363.0 11048.0 11634.0 True False 6016.7364403330475 9936.080936338645 10586.069557751798 12766.938503077874 12916.209296644445 8454.097701729115 9876.571750447767 11396.06444875408 13257.908706911887 11298.096191237844 0.5325442745831181 0.8794473660123818 0.9369781756648299 1.1300079488594883 1.1432199795450066 0.7482763076743522 0.8741801789674503 1.008671218217474 1.173463960874573 1.0 13.463792068397082 -4.667736544972355 1.836768639659513 0.998970324630075 0.27987011988002986 0.5724740437378132 0.12248862806010284 0.962409703738029 2.6572540108287064 0.03602720059769899 1.3218575348531445 2.1491338026953638e-05 4.667736544972355 -0.7191002047500451 APGLGVLSPS(ph)GEER ddPTM_A459_Selumetinib_30min_R1 1 APGLGVLSPSGEER 14 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 APGLGVLS(0.119)PS(0.881)GEER 125.47 0.0013769 15307000.0 1001.0 1031.1 1052.3 1054.6 1117.3 1416.1 948.74 786.96 451.03 778.8 True False 1024.3213523930606 910.3783326546144 909.4034398701452 870.4339072937872 1016.2404122753361 1401.8553197159242 877.1757779650444 766.0872643936602 765.3649680721588 878.7665661544049 1.165635325517244 1.0359728825808048 1.034863494920854 0.9905177789170081 1.1564395499507159 1.5952533627338858 0.9981897488472712 0.8717756158454643 0.8709536725111129 1.0 9.7793361713238 -7.512779889873603 24.970816673326116 0.9098152517192573 1.1561368265162375 0.33210104530043794 0.16142503952922674 626.1262307625121 1548195.0411720155 0.07770485527158176 0.04835894831322116 3.0705778313960106e-08 7.512779889873603 0.24632157479698025 APGLGVLSPS(ph)GEER ddPTM_A459_Selumetinib_30min_R2 1 APGLGVLSPSGEER 14 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 APGLGVLS(0.253)PS(0.747)GEER 180.3 7.3585e-05 8490300.0 10312.0 11558.0 17838.0 18239.0 20743.0 14837.0 14192.0 13633.0 13007.0 15323.0 True False 9738.9003222067 12444.461435172478 16690.32250054591 15754.816735970062 18137.07889522717 16880.66207312396 14851.956120914494 13672.669772935355 15608.76344594525 14880.585176064762 0.6544702514704598 0.8362884448381265 1.1216173492553296 1.0587498105458575 1.2188417781042937 1.1344084841687743 0.9980760800189284 0.918826081848426 1.048934787259022 1.0 13.861143640807683 -5.024014012715508 2.9867127667733486 1.0649541614779263 0.660369254074299 0.7322752951083359 0.08005325566526691 0.15105897646963823 2.547284573945373 0.02354049652701458 0.11084483854359543 9.462066310717403e-06 5.024014012715508 -0.4045849074036273 APGPPYS(ph)PVPAESESLVNGNHTPQTATR ddPTM_A459_Selumetinib_30min_R2 1 APGPPYSPVPAESESLVNGNHTPQTATR 28 0 Q86UU1-3;Q86UU1-2;Q86UU1;A0A087WXY7;A0A087WTZ7 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 APGPPY(0.305)S(0.342)PVPAES(0.331)ES(0.023)LVNGNHTPQTATR 65.275 0.00064544 5051800.0 8116.1 9357.7 10848.0 13388.0 15633.0 7255.2 8701.0 8734.9 7889.9 12801.0 True False 7665.039653322513 10075.405500252073 10150.051490409358 11564.531304411825 13669.04277920679 8254.537943851788 9105.613740704419 8760.317112859459 9468.100462225217 12431.401869007701 0.6165869090301037 0.8104802343628451 0.8164848660965663 0.930267674255062 1.0995576302045715 0.6640070066780556 0.7324687783929913 0.7046926167433701 0.7616277361147669 1.0 13.6017013754914 -10.156700248404572 15.702653037369775 0.9999551583378813 0.799014093010837 0.18007493772308247 0.1319923380120521 0.0 0.0 0.1367193792140984 0.0331593200922708 6.971074941754587e-11 10.156700248404572 -0.20094106532704425 APGPS(ph)PAKEK ddPTM_A459_Selumetinib_30min_R2 1 APGPSPAKEK 10 1 Q9H9J4-2;Q9H9J4;C9JPC9 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 APGPS(1)PAKEK 69.229 0.042663 10441000.0 136980.0 138760.0 111600.0 150870.0 125060.0 84672.0 100200.0 103980.0 61958.0 152430.0 True False 129367.19997438655 149402.4458162773 104419.7775008926 130321.24573473318 109348.84474941471 96334.79942411216 104859.49854253318 104282.56458518445 74351.33125116285 148028.94983929725 0.8739317553413017 1.0092785632707058 0.7054010557681621 0.8803767497926057 0.7386990508824502 0.6507835090953146 0.7083715628353132 0.704474122787437 0.5022756111684905 1.0 17.175519823975364 -5.684813564339625 0.9016567232655021 0.6950689501248496 0.9487374958393902 0.2328303788727215 0.13333300308943288 1.004609641954167 1.4359046996421376 0.05267203824555463 0.1928115439412995 2.066266980744541e-06 5.684813564339625 0.25366854571454056 APGS(ph)PAAPR ddPTM_A459_Selumetinib_30min_R1 2 APGSPAAPR 9 0 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 APGS(1)PAAPR;APGS(1)PAAPR 102.95 0.01567 17858100.0 1775.86 1308.9 1892.5900000000001 2080.5 1866.6 1487.35 1487.9099999999999 1957.72 1018.78 1465.04 True False 1817.2340827779633 1155.6533795088983 1635.5866732527222 1717.1797308218506 1697.7663595749968 1472.3886094057484 1375.6757507767863 1905.794906029222 1728.7952512528093 1653.092154698062 1.0992938763960693 0.6990858774718334 0.9894104624502698 1.03876830214314 1.0270246306293158 0.890687554968574 0.8321833400921645 1.1528667053515333 1.0457948435237565 1.0 10.690951437253606 -7.768355709701099 24.999848675633192 1.0744980640835649 0.9374745739211413 0.205123831249707 0.11392209224672883 252.4629662590949 912537.5589262338 0.060478731877723645 0.030062781866645738 1.704685591160331e-08 7.768355709701099 -0.13702349016242354 APGS(ph)PAAPR ddPTM_A459_Selumetinib_30min_R2 4 APGSPAAPR 9 0 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 APGS(1)PAAPR;APGS(1)PAAPR;APGS(1)PAAPR;APGS(1)PAAPR 110.38 0.010884 40922500.0 26795.6 14668.800000000001 22977.100000000002 28365.799999999996 26641.4 18000.9 29270.1 19882.3 21608.0 16957.1 True False 25306.40782328566 15793.84979237393 21498.778401574942 24502.32910626565 23294.46915486212 20480.360579099342 30631.217647602825 19940.154201308043 25930.203777964532 16467.504463163074 1.536748198847903 0.9590918786573842 1.3055274070012588 1.487919991828516 1.414571904745531 1.2436833173425161 1.8601007648805088 1.2108789310434438 1.574628616981341 1.0 14.007334320685032 -5.529855084736079 16.988016123839603 1.4191574262609112 1.2190183538595447 0.05042082750617771 0.2533238453621452 7.232858775165535 17611.341003601337 0.06403290682196369 0.1120889076461993 2.9521941496691223e-06 5.529855084736079 -0.20013907240136652 APGTPHSHTKPYVR ddPTM_A459_Selumetinib_30min_R1 1 APGTPHSHTKPYVR 14 1 F8VUA6;H0YHA7;J3QQ67;Q07020-2;Q07020;F8VYV2 F8VUA6 RPL18 60S ribosomal protein L18 0 89.44 0.015543 3644600.0 1959.7 1585.8 2112.5 2064.5 2315.0 1312.4 1591.7 1610.3 965.4 1416.8 False True 2005.357197087594 1400.1337987815803 1825.6341031318848 1703.9738304646526 2105.608658746447 1299.198447563858 1471.6367875149783 1567.5896130084266 1638.2132899737546 1598.6600808006704 1.25439874378 0.8758170768111877 1.141977663079907 1.0658762615822852 1.317108423506689 0.8126796078583319 0.9205439012262858 0.9805646815321225 1.0247414754694284 1.0 10.642647499355421 -6.77703117281023 24.998297538866698 0.9447936443552718 1.1138448104440801 0.35548900409453743 0.12230389545699939 299.8421342398851 480733.51998649316 0.04261758409308286 0.03771149598036365 1.670970670992843e-07 6.77703117281023 0.16905116608880832 APGTPHSHTKPYVR ddPTM_A459_Selumetinib_30min_R2 1 APGTPHSHTKPYVR 14 1 F8VUA6;H0YHA7;J3QQ67;Q07020-2;Q07020;F8VYV2 F8VUA6 RPL18 60S ribosomal protein L18 0 54.343 0.046688 6403900.0 25474.0 27049.0 35570.0 35660.0 38511.0 25723.0 27288.0 24528.0 22980.0 26822.0 False True 24058.257060501674 29123.571323756725 33281.46492568777 30803.046483068836 33672.90388729178 29266.109759854928 28556.946070146205 24599.372419171006 27576.6421148475 26047.57916807474 0.9236273707150766 1.1180912873259286 1.27771815994629 1.1825684945349026 1.2927460041493235 1.123563520855903 1.0963378164964779 0.9444014839321909 1.0587026892943225 1.0 14.668861675872662 -7.468710272152008 2.7659061563500793 1.001900996584969 1.1651091129578435 0.3104271758274675 0.09945481766176122 0.33815154825104454 5.113189167752942 0.05313717826715079 0.03082194025449142 3.398519200216756e-08 7.468710272152008 0.16320811637287447 APGYPS(ph)SPVTTASGTTLR ddPTM_A459_Selumetinib_30min_R1 1 APGYPSSPVTTASGTTLR 18 0 Q9HCK8-2;Q9HCK8;H0YJG4;H0YJA4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 APGYPS(0.497)S(0.497)PVT(0.004)T(0.001)AS(0.001)GTTLR 125.36 0.00082958 28801000.0 1575.6 1614.6 1964.9 2441.4 2116.3 1568.6 2104.4 1731.6 838.52 1612.1 True False 1612.308414416091 1425.5618813928243 1698.0773724231192 2015.05532075389 1924.881038663113 1552.821308174847 1945.6634137378392 1685.6723429704969 1422.9071969223048 1819.0287381837659 0.886356757632055 0.7836939854046484 0.9335077213340718 1.107764423098587 1.0581916592395548 0.8536540823017907 1.0696166437043284 0.9266881317408868 0.7822345887415864 1.0 10.828952620453956 -5.45125294866519 6.385184925179786 0.9745497792383254 0.8385025323086304 0.23458109216068723 0.09678760736464324 0.33681812996858984 24.177869046780994 0.02623308049127979 0.05486201085461251 3.5379122038163152e-06 5.45125294866519 -0.13604724692969505 APGYPS(ph)SPVTTASGTTLR ddPTM_A459_Selumetinib_30min_R2 2 APGYPSSPVTTASGTTLR 18 0 Q9HCK8-2;Q9HCK8;H0YJG4;H0YJA4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 APGYPS(0.954)S(0.043)PVT(0.002)TASGTTLR;APGYPS(0.922)S(0.078)PVTTASGTTLR 278.89 1.8464999999999997e-111 64136000.0 34502.1 28638.9 44546.5 35924.0 45990.2 35375.6 27952.2 34647.5 30735.7 31398.5 True False 32584.61140484947 30835.411541422483 41680.42668856198 31031.089227643435 40212.49991839546 40248.26779227633 29252.03268623354 34748.31848879758 36883.698827211425 30491.94372189972 1.0686301831734908 1.0112642153171785 1.3669324287328573 1.017681572242851 1.3187909660712873 1.3199639930913782 0.9593364382744921 1.1395901424231238 1.209621110533569 1.0 14.89614049803638 -10.554965352750923 4.309039208485988 0.9999896144004969 1.15791155603022 0.10563926755891362 0.13689981235641696 48000838.34344186 1.8195022983913953 5075.544781155605 0.03287135882302089 2.786343449337372e-11 10.554965352750923 0.15792194162972306 APGYPSS(ph)PVTTASGTTLR ddPTM_A459_Selumetinib_30min_R1 3 APGYPSSPVTTASGTTLR 18 0 Q9HCK8-2;Q9HCK8;H0YJG4;H0YJA4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 APGYPS(0.127)S(0.872)PVTTASGTTLR;APGYPS(0.135)S(0.865)PVTTASGTTLR;APGYPS(0.277)S(0.722)PVTTASGTTLR 281.49 4.5090999999999986e-67 113742000.0 4538.88 5032.6 5522.0 5210.9 5090.15 4583.51 4381.64 4377.950000000001 2224.41 3679.31 True False 4644.627072876941 4443.380852407733 4772.142730174799 4300.9141357075605 4629.746831238974 4537.404050894105 4051.1293671213994 4261.832544414236 3774.661305521564 4151.585278014336 1.1187598861267816 1.0702853379740667 1.149474817594803 1.0359691172632366 1.115175654889435 1.092932879139677 0.9758029995373276 1.0265554623155013 0.9092096278284687 1.0 12.019446617752033 -7.2569043596931575 12.714290164530965 0.9800982931751253 1.096310814235717 0.685807518285918 0.03951468739221572 0.27915327882976443 776.1470597409434 0.014676447544815537 0.0108119492094318 5.5347198136510354e-08 7.2569043596931575 0.11621252106059166 APGYPSS(ph)PVTTASGTTLR ddPTM_A459_Selumetinib_30min_R2 4 APGYPSSPVTTASGTTLR 18 0 Q9HCK8-2;Q9HCK8;H0YJG4;H0YJA4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 APGYPS(0.205)S(0.68)PVT(0.087)T(0.027)AS(0.002)GTTLR;APGYPS(0.024)S(0.612)PVT(0.285)T(0.077)AS(0.001)GT(0.001)TLR;APGYPS(0.102)S(0.883)PVT(0.011)T(0.003)ASGTTLR;APGYPS(0.099)S(0.89)PVT(0.005)T(0.005)ASGTTLR 189.45 2.1884e-10 78996900.0 73987.5 82430.2 87310.7 88538.3 98418.4 74744.90000000001 67611.7 73262.0 67903.2 70176.9 True False 69875.57094542941 88752.33128513192 81693.22461870236 76479.23080291325 86054.20072034071 85040.3315083537 70755.77802004197 73475.18029082293 81485.73737393 68150.7105555165 1.0253094997227918 1.3022950246840501 1.1987142019913928 1.1222073868270563 1.2627043800260862 1.2478275107502905 1.0382250961624726 1.078127868248256 1.195669666680153 1.0 16.05644107853996 -8.69237104034153 0.46268463726315767 0.9985467895121023 1.1943755100099627 0.2301606742243667 0.09047095928746544 1.971088648221406 0.9765441365655121 0.12840036253616846 0.05641262995011614 2.0306214042569694e-09 8.69237104034153 0.19582872049786038 APIDT(ph)SDVEEK ddPTM_A459_Selumetinib_30min_R1 1 APIDTSDVEEK 11 0 D6RIY6;Q06265-3;Q06265-4;Q06265;Q06265-2 D6RIY6 EXOSC9 Exosome complex component RRP45 1 APIDT(0.546)S(0.454)DVEEK 123.26 0.0091557 8132700.0 1468.5 1614.9 1226.8 1164.1 1097.1 1311.9 1241.6 1185.4 913.12 1470.7 True False 1502.7131927964135 1425.8267572533584 1060.2072983300343 960.8117878633581 997.8674987087364 1298.703477109895 1147.945112382105 1153.9593412781392 1549.4979483538787 1659.4786708311306 0.9055332974203261 0.8592016169386797 0.6388797379354335 0.5789841139579979 0.6013138440694548 0.7825972698157394 0.6917504470287467 0.695374614667504 0.9337257390466072 1.0 10.696514371334157 -8.350910728444509 3.836258781607171 0.9943856037672033 0.7134528868204773 0.4966900854102426 0.10033084389751187 0.20725778713191823 5.30378053773148 0.10532031993002326 0.028157876305243437 4.457478648407182e-09 8.350910728444509 -0.28093271694672606 APIDTS(ph)DVEEK ddPTM_A459_Selumetinib_30min_R1 2 APIDTSDVEEK 11 0 D6RIY6;Q06265-3;Q06265-4;Q06265;Q06265-2 D6RIY6 EXOSC9 Exosome complex component RRP45 1 APIDT(0.028)S(0.972)DVEEK;APIDT(0.078)S(0.922)DVEEK 166.62 0.00058404 125084000.0 11105.0 11339.3 6295.5 5134.1 6732.5 7547.700000000001 10134.3 10915.3 5914.3 11230.8 True False 11363.72489343151 10011.689484502442 5440.605678706171 4237.525813993014 6123.546563719417 7471.7769907632855 9369.86159182826 10625.790786108715 10036.135136618788 12672.382577255908 0.8967315202294203 0.7900400278690437 0.42932776417836693 0.3343906158261371 0.48321983071358754 0.5896110652604076 0.7393922598774018 0.8384998417882074 0.7919690772776546 1.0 13.62940017547562 -7.528989054720979 1.9271019555851048 0.8755415290073405 0.5715607732520357 0.3947862335874802 0.16150290392296682 0.4156322125899036 3.0395419690443397 0.11153831810718788 0.056186830861204004 2.958087016611763e-08 7.528989054720979 -0.3039807557553048 APIDTS(ph)DVEEK ddPTM_A459_Selumetinib_30min_R2 3 APIDTSDVEEK 11 0 D6RIY6;Q06265-3;Q06265-4;Q06265;Q06265-2 D6RIY6 EXOSC9 Exosome complex component RRP45 1 APIDT(0.029)S(0.971)DVEEK;APIDT(0.314)S(0.686)DVEEK;APIDT(0.049)S(0.951)DVEEK 223.36 5.9172e-06 212754000.0 297539.0 197519.0 236661.0 274056.0 252115.0 243678.0 387930.0 357790.0 276294.0 205607.0 True False 281002.97352298844 212668.0721763139 221434.488917014 236729.10002703033 220442.059763303 277242.4326113567 405969.5136687125 358831.10966467665 331560.52029937686 199670.59167885827 1.4073328032950478 1.0650946160281842 1.1089990120986863 1.1855982297471999 1.1040286799863481 1.3884990788090703 2.0331963272871785 1.7971154722764855 1.6605375759723533 1.0 17.607262336696166 -7.018103336218265 6.5095573107985265 1.6936699534573025 1.1716051545939032 0.3841353507075911 0.2615634782981942 0.14265092278284006 25.460220067994783 0.09292817861618628 0.07544121647049651 9.5917237846801e-08 7.018103336218265 -0.5220647988633993 APIRPDIVNFVHTNLR ddPTM_A459_Selumetinib_30min_R1 2 APIRPDIVNFVHTNLR 16 1 P36578;H3BU31;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 ; 94.007 0.0076113 23067000.0 5363.5 5989.7 6310.1 5490.0 6365.0 6057.7 5449.5 6013.1 3261.6000000000004 5034.799999999999 False True 5488.459114445738 5288.423139464013 5453.223078898228 4531.274560063425 5789.286873832023 5996.76503795153 5038.4398275823805 5853.613054698481 5534.696982161173 5681.065623105034 0.9660967639810459 0.9308857686761908 0.9598944002195353 0.7976099662772104 1.0190494632357088 1.0555704573385913 0.8868828775874232 1.0303723707910877 0.9742357067046407 1.0 12.47194585259177 APKPDGPGGGPGGSHMGGNYGDDR ddPTM_A459_Selumetinib_30min_R1 5 APKPDGPGGGPGGSHMGGNYGDDR 24 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 ;;;; 150.63 1.6093e-08 41039200.0 17561.800000000003 18401.2 16063.600000000002 15119.000000000002 17382.399999999998 14108.5 17290.1 17006.100000000002 10354.9 15796.6 False True 17970.95577068577 16246.7789495142 13882.25135103875 12478.75046877941 15810.16498911197 13966.58129949306 15985.893836660625 16555.042984402033 17571.509008026955 17824.247481914073 1.0082308265143063 0.9114987303671305 0.7788408102571964 0.7000997086379867 0.8870032244084496 0.7835720028946347 0.8968622014972137 0.9287933754959429 0.9858205248696436 1.0 14.121553548671464 -7.856620363075344 1.7302782743016818 0.9934348021295432 0.8404410603848029 0.3466847267133989 0.07960279445174842 0.4568193246822625 2.5573151823065845 0.06897045597318943 0.025349574780005418 1.3911681844039875e-08 7.856620363075344 -0.15299374174474023 APKPDGPGGGPGGSHMGGNYGDDR ddPTM_A459_Selumetinib_30min_R2 3 APKPDGPGGGPGGSHMGGNYGDDR 24 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 ;; 87.46799999999998 6.7887e-05 18169300.0 85516.0 69220.0 88398.0 92489.0 87460.0 71942.0 83072.0 85262.0 75610.0 71964.0 False True 80763.36306767142 74528.95142261985 82710.56892046513 79891.83864757593 76472.49289767956 81851.35747554655 86935.0126040452 85510.09830411598 90734.11271991405 69886.21233507323 1.1556408677644041 1.0664328332073107 1.1835033858167163 1.143170247437795 1.0942429177736526 1.1712089515326112 1.2439508409359856 1.2235617791694473 1.2983120659749656 1.0 16.092720237756076 -6.994653756565574 6.901559613733714 1.2098958573481768 1.1291736221839592 0.10893887857512441 0.07888553343794523 0.22619655906319697 59.249999753578706 0.026993092170015096 0.02287150311181205 1.0123862625812579e-07 6.994653756565574 -0.08072223516421762 APKPPTDGSTS(ph)PTSTPSEDQEALGK ddPTM_A459_Selumetinib_30min_R1 1 APKPPTDGSTSPTSTPSEDQEALGK 25 1 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 APKPPT(0.001)DGS(0.049)T(0.205)S(0.725)PT(0.014)S(0.004)T(0.001)PSEDQEALGK 80.36 0.00010795 7416800.0 1276.5 1317.9 1526.9 1684.6 1332.5 1150.7 1413.0 1386.6 678.98 1343.0 True False 1306.2399663633794 1163.5996553249126 1319.5553666613382 1390.4162338584429 1211.9756102719823 1139.1250027520061 1306.416272387174 1349.8228636884326 1152.1794692628753 1515.3871319277955 0.8619843331397765 0.7678563654190745 0.8707711309272301 0.9175320316265513 0.7997795314060578 0.7517056062782264 0.8621006770231844 0.8907445729536182 0.7603202145428893 1.0 10.565470686918312 -11.405534189009488 2.6627307833685223 1.0814978913222966 0.8326139205858439 0.4533710815560842 0.05551801080464272 32987512.09965908 21186565.478923034 16951343.005603008 0.014569509058494525 3.930663002903789e-12 11.405534189009488 -0.24888397073645263 APKPPTDGSTS(ph)PTSTPSEDQEALGK ddPTM_A459_Selumetinib_30min_R2 2 APKPPTDGSTSPTSTPSEDQEALGK 25 1 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 APKPPTDGS(0.004)T(0.078)S(0.383)PT(0.383)S(0.117)T(0.036)PSEDQEALGK;APKPPTDGS(0.006)T(0.08)S(0.385)PT(0.385)S(0.119)T(0.025)PSEDQEALGK 96.128 3.9404e-06 25115000.0 101737.0 84935.0 101993.0 106109.0 97469.0 73151.0 88712.0 91741.0 73297.0 95151.0 True False 96082.8648254794 91449.24139093063 95430.88142158189 91656.77115176548 85224.07283608436 83226.88625133732 92837.28377949311 92007.95112145982 87958.44808929392 92403.74339801192 1.039815718413272 0.9896703101846215 1.0327599068203452 0.9919162122790957 0.9223010854549207 0.9006873876619154 1.0046918053916256 0.9957167073324367 0.9518926923818365 1.0 16.49566367786128 -6.009156656414886 9.999629725784116 0.9609518595134625 1.0167983280597306 0.37420556033568964 0.03372663859952563 0.250739908526852 251.17363513325105 0.010349742497450855 0.014331737966089438 9.791367326629108e-07 6.009156656414886 0.05584646854626807 APKPPTDGSTSPT(ph)STPSEDQEALGK ddPTM_A459_Selumetinib_30min_R1 1 APKPPTDGSTSPTSTPSEDQEALGK 25 1 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 APKPPTDGS(0.017)T(0.236)S(0.236)PT(0.377)S(0.124)T(0.009)PSEDQEALGK 101.16 4.2543e-06 7090100.0 2829.0 3284.7 3102.9 3924.8 3128.0 2900.8 3422.8 3167.9 1852.2 2947.6 True False 2894.910195724244 2900.1257969844 2681.5432230096694 3239.407357620571 2845.0729522932556 2871.620585715665 3164.6154402879097 3083.877001210576 3143.048120664373 3325.9531720553746 0.870400166799476 0.8719683191426831 0.8062480390704141 0.9739786431264394 0.8554158176962713 0.8633977801741145 0.9514912798162575 0.9272160014522393 0.9450067268151073 1.0 11.699552140924347 -7.965085236305886 0.39223798331891074 1.0054518942128905 0.8565662735949097 0.4962160893869305 0.04153576719979574 0.9607057861966869 0.4299066794985854 0.05340014350753789 0.04168524576721446 1.0837141992296436e-08 7.965085236305886 -0.14888562061798083 APLATGEDDDDEVPDLVENFDEASK ddPTM_A459_Selumetinib_30min_R2 1 APLATGEDDDDEVPDLVENFDEASK 25 0 P20290;P20290-2 P20290 BTF3 Transcription factor BTF3 0 104.67 4.862899999999999e-07 1773300.0 7304.2 6131.3 6426.3 7616.8 7330.1 6267.4 8416.5 7766.3 9411.9 6601.0 False True 6898.261805029296 6601.5509947631945 6012.838854426407 6579.3787002871195 6409.227306074561 7130.677460207391 8807.883926978358 7788.898647219823 11294.542990458374 6410.411978542294 1.0761027260213527 1.029816962912946 0.9379800977773829 1.0263581689149484 0.999815195579988 1.1123586883457814 1.3739965475637406 1.21503870161415 1.7619059474281582 1.0 12.646201362301834 -7.137596156102627 2.647120173237646 1.3612644312127609 1.0112099529212835 0.41593815210511165 0.18009781697299057 0.25978254530440975 3.5360920526972888 0.07356791177118276 0.053932402227092925 7.284568707632899e-08 7.137596156102627 -0.3500544782914774 APLATGEDDDDEVPDLVENFDEASKNEAN ddPTM_A459_Selumetinib_30min_R1 4 APLATGEDDDDEVPDLVENFDEASKNEAN 29 1 P20290;P20290-2 P20290 BTF3 Transcription factor BTF3 0 ;;; 163.61 6.4798e-19 42376600.0 6649.15 8010.32 9252.0 10296.09 8216.11 7269.02 6918.98 6881.42 3990.76 5669.95 False True 6804.062258006312 7072.468010503263 7995.629217598204 8498.071163046168 7472.964301172038 7195.9002585420885 6397.075768097247 6698.902387597618 6772.028246421853 6397.743312489945 1.063509729238923 1.1054629210734497 1.2497577391060373 1.3282919848403223 1.1680625395806363 1.1247560127168508 0.9998956593973699 1.0470727036703298 1.0585026493953287 1.0 12.643347395085874 -7.012048603331982 2.8933896319832324 1.0306756736168432 1.19018157142793 0.5216155810428809 0.07039387685557087 0.24483842422531524 4.150469411359973 0.03185603586752246 0.02549683128946679 9.72638366509007e-08 7.012048603331982 0.15950589781108682 APLATGEDDDDEVPDLVENFDEASKNEAN ddPTM_A459_Selumetinib_30min_R2 5 APLATGEDDDDEVPDLVENFDEASKNEAN 29 1 P20290;P20290-2 P20290 BTF3 Transcription factor BTF3 0 ;;;; 114.62 4.8902e-10 12586200.0 53252.299999999996 53209.299999999996 55187.5 54576.7 53483.4 40592.5 37353.5 43813.0 33397.700000000004 51843.6 False True 50292.75035184714 57290.28221513434 51636.79633360676 47143.25930994115 46764.337144337514 46183.74841297324 39090.51176455608 43940.4885763674 40078.17320970598 50346.74056215046 0.998927632460404 1.137914422571456 1.0256234218352982 0.9363716257211373 0.9288453755334836 0.9173135717884613 0.7764258684492367 0.8727573639474264 0.7960430558604193 1.0 15.619610761018178 -6.023217999004768 1.1231186591635758 0.8582133804907435 1.076733039479086 0.5638879083728454 0.06806107398085214 0.33647838136685787 0.8654410326558691 0.026031739615419408 0.05083082501352651 9.479425134395064e-07 6.023217999004768 0.21851965898834247 APLKPYPVS(ph)PSDK ddPTM_A459_Selumetinib_30min_R2 1 APLKPYPVSPSDK 13 1 J3KR24;A0A0A0MSX9;P41252;Q5TCC6 J3KR24 IARS Isoleucine--tRNA ligase, cytoplasmic 1 APLKPYPVS(0.791)PS(0.209)DK 160.87 0.0017271 6799100.0 31426.0 28820.0 30812.0 30138.0 32415.0 22666.0 26196.0 28369.0 22058.0 23122.0 True False 29679.468728245512 31030.40132909419 28829.589465569046 26033.152409050133 28342.737906223243 25788.035758537957 27414.165906389255 28451.549093259244 26470.21635201506 22454.407781829246 1.3217658206182126 1.3819291798114082 1.2839167145124522 1.159378268266639 1.2622349331857687 1.1484620752013945 1.220881270739796 1.267080805234287 1.1788427737308451 1.0 14.454711052168609 -12.979564630012234 0.04010512530452828 5.359837601333678e-12 1.9317082927570774 0.6915097151025286 0.05650292089213028 400.20489775772785 1.5770161612801752 59.52421152310513 23.60822944984126 1.048178796090421e-13 12.979564630012234 1.9317082927517175 APLKPYPVSPS(ph)DK ddPTM_A459_Selumetinib_30min_R1 1 APLKPYPVSPSDK 13 1 J3KR24;A0A0A0MSX9;P41252;Q5TCC6 J3KR24 IARS Isoleucine--tRNA ligase, cytoplasmic 1 APLKPYPVS(0.355)PS(0.645)DK 112.42 0.023333 18097000.0 2274.4 3270.0 1931.0 1867.0 2002.4 2339.5 2781.2 2095.9 1313.8 2282.5 True False 2327.3890947879904 2887.1468798182427 1668.7808062237496 1540.9634979304954 1821.2832735524344 2315.9667540960427 2571.4118448430354 2040.309923557324 2229.4226438445403 2575.481108432755 0.9036715847643182 1.1210126412362404 0.6479491543384858 0.5983206372141516 0.7071623502067663 0.8992365529349066 0.9984199986649501 0.7922053541285357 0.8656334680712141 1.0 11.330626242362452 -8.559736681900592 16.426219029151433 1.0000000120349108 0.8323084802616944 0.0986733767719743 0.15050703474728197 290.6971461432973 129556.39389349005 0.15947701657031416 0.04117774688245805 2.7558991325115056e-09 8.559736681900592 -0.1676915317732165 APLKPYPVSPS(ph)DK ddPTM_A459_Selumetinib_30min_R2 1 APLKPYPVSPSDK 13 1 J3KR24;A0A0A0MSX9;P41252;Q5TCC6 J3KR24 IARS Isoleucine--tRNA ligase, cytoplasmic 1 APLKPYPVS(0.294)PS(0.706)DK 108.71 0.029347 8254400.0 29958.0 27288.0 38480.0 30222.0 40100.0 36546.0 32505.0 37474.0 27546.0 29136.0 True False 28293.054291375895 29380.901855250606 36004.23869385618 26105.711464142056 35062.27950145154 41579.87976844296 34016.546907435564 37583.04313584535 33055.969699546986 28294.767975580682 0.9999394345906542 1.0383863858013358 1.2724698334663507 0.9226338765764803 1.2391789016157138 1.469525383785715 1.2022203870621229 1.328268292154958 1.1682714531561234 1.0 14.78824768654597 -6.432186791048243 9.531232062027518 1.263443876941274 1.0727376682664544 0.25941783990166845 0.14063808179236958 0.5337461913613661 52.92380060155585 0.04202238270931018 0.04762706037194052 3.696691500377346e-07 6.432186791048243 -0.19070620867481947 APPGLTPAPAS(ph)PPVLPR ddPTM_A459_Selumetinib_30min_R2 2 APPGLTPAPASPPVLPR 17 0 C9J069 C9J069 C9orf172 Uncharacterized protein C9orf172 1 APPGLT(0.035)PAPAS(0.965)PPVLPR;APPGLT(0.177)PAPAS(0.823)PPVLPR 95.751 0.006268600000000001 11471100.0 30048.0 15380.7 34022.0 40364.0 42737.0 28517.0 21617.0 25684.6 31133.0 32139.0 True False 28378.05245167443 16560.35023325464 31833.061560352795 34866.35356821621 37367.99598637246 32444.95789844817 22622.23333327289 25759.33793368558 37360.46992870095 31211.063562849682 0.9092305487933655 0.5305923074331346 1.0199287664853394 1.117115201729857 1.197267626305799 1.039533876604807 0.7248145609558778 0.825327143428292 1.197026492015186 1.0 14.929769899597511 -5.287070286686136 24.447146182393027 1.0095392973661987 0.7199114325389797 0.34037318576494424 0.16424077929829864 596.5298980965117 568978.3786548624 0.045574564773969546 0.09493106700125777 5.163327986541036e-06 5.287070286686136 -0.28962786482721903 APPPPIS(ph)PTQLSDVSSPR ddPTM_A459_Selumetinib_30min_R1 2 APPPPISPTQLSDVSSPR 18 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2 Q9P0K7 RAI14 Ankycorbin 1 APPPPIS(0.887)PT(0.101)QLS(0.011)DVS(0.001)SPR;APPPPIS(0.972)PT(0.024)QLS(0.004)DVSSPR 127.49 0.00072531 9868200.0 363.9 426.78999999999996 418.25 299.88 362.86 330.12 406.35 142.29 0.0 416.65 True False 372.378161973861 376.82122839071206 361.45394728279825 247.51158744477604 330.03937706813645 326.799292524978 375.6986923457381 138.51600697694155 0.0 470.13108601468025 0.7920730473930694 0.8015237443348843 0.7688365182291127 0.5264735619653266 0.7020156439045401 0.6951237691922661 0.7991360357183583 0.2946327335023668 0.0 1.0 8.87691926736334 -7.762609938409798 24.999910460340914 0.3604872081358177 0.7211354079961035 0.21745111590589983 0.24536786556918547 37.01191910407506 790403.0704954987 0.11887235357026484 0.06213307670779684 1.7273886496002125e-08 7.762609938409798 0.36064819986028585 APPPPIS(ph)PTQLSDVSSPR ddPTM_A459_Selumetinib_30min_R2 2 APPPPISPTQLSDVSSPR 18 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2 Q9P0K7 RAI14 Ankycorbin 1 APPPPIS(0.543)PT(0.224)QLS(0.219)DVS(0.011)S(0.003)PR;APPPPIS(0.987)PT(0.013)QLSDVSSPR 163.0 6.1815999999999985e-06 15454300.0 75697.6 69461.9 96250.3 100430.0 100540.0 75523.3 62975.0 55475.0 56505.0 84019.0 True False 71490.63043350216 74789.40437478853 90057.66048740319 86751.26074858662 87909.26636099591 85925.94904274188 65903.46228259514 55636.42306561938 67807.57888161267 81593.15316242147 0.876184185346913 0.91661372892295 1.1037404119942766 1.0632174071750515 1.0774098432744892 1.0531024444133863 0.8077082417859986 0.6818761245182922 0.8310449621506002 1.0 16.316160473988162 -7.267816744290668 23.907154367730815 0.8036469775712398 1.0196266133086163 0.4447106070280159 0.09938410520697524 239.18150493486326 896625.3595090152 0.04207182302503124 0.02918845293696083 5.397383234605083e-08 7.267816744290668 0.21597963573737644 APPQTHLPSGAS(ph)SGTGSASATHGGGSPPGTR ddPTM_A459_Selumetinib_30min_R1 2 APPQTHLPSGASSGTGSASATHGGGSPPGTR 31 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;A0A0G2JJR8;A0A1B0GX79;F6X9W3;F6VEM6;F6U341;F6TC96;F6S6P2;X6REW1;A0A0G2JJM1;F6XTU0;F6U1F2;F6UR09;F6WML8 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 APPQTHLPS(0.042)GAS(0.776)S(0.082)GT(0.018)GS(0.04)AS(0.009)AT(0.023)HGGGS(0.008)PPGT(0.002)R;APPQTHLPS(0.026)GAS(0.554)S(0.056)GT(0.129)GS(0.025)AS(0.002)AT(0.003)HGGGS(0.182)PPGT(0.023)R 94.767 3.8839e-08 47922700.0 1126.75 1423.98 914.56 1304.46 2298.88 1377.99 1989.49 1513.94 305.74 674.51 True False 1153.0010827261547 1257.2597596096575 790.3677753184833 1076.6605487468744 2090.9467099002295 1364.1286717148132 1839.4211675524123 1473.7853932298183 518.818449633909 761.0899287837805 1.514934095329112 1.6519201109634376 1.0384683142260058 1.4146298722772155 2.747305713585721 1.7923357281769408 2.4168250005512517 1.9364142626153562 0.6816782485388808 1.0 9.571923119384229 -6.053050776673457 24.999103061235786 1.8650539868639777 1.3934107304151118 0.06589779771600657 0.5873223374812344 694.6271118992811 327327.45337432984 0.17299410580681457 0.22333634061395613 8.850121302773535e-07 6.053050776673457 -0.47164325644886596 APPQTHLPSGASSGTGSASAT(ph)HGGGSPPGTR ddPTM_A459_Selumetinib_30min_R1 1 APPQTHLPSGASSGTGSASATHGGGSPPGTR 31 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;A0A0G2JJR8;A0A1B0GX79;F6X9W3;F6VEM6;F6U341;F6TC96;F6S6P2;X6REW1;A0A0G2JJM1;F6XTU0;F6U1F2;F6UR09;F6WML8 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 APPQTHLPS(0.001)GAS(0.037)S(0.037)GT(0.002)GS(0.014)AS(0.215)AT(0.496)HGGGS(0.18)PPGT(0.019)R 76.452 3.7744e-05 5511500.0 402.24 541.7 480.15 487.12 1168.5 571.53 955.69 366.55 121.67 148.71 True False 411.61140937720756 478.2775121705021 414.94826727515976 402.0536363748809 1062.8093813154305 565.7809271077199 883.6015338695668 356.8279032777983 206.46510357479457 167.7983770580658 2.4530118621753503 2.850310715490392 2.4728979776220896 2.3960519965920306 6.333847799658102 3.371790222452117 5.2658526820184965 2.1265277384317 1.230435640645966 1.0 7.390584951907627 APPQTHLPSGASSGTGSASATHGGGS(ph)PPGTR ddPTM_A459_Selumetinib_30min_R1 2 APPQTHLPSGASSGTGSASATHGGGSPPGTR 31 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;A0A0G2JJR8;A0A1B0GX79;F6X9W3;F6VEM6;F6U341;F6TC96;F6S6P2;X6REW1;A0A0G2JJM1;F6XTU0;F6U1F2;F6UR09;F6WML8 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 APPQTHLPS(0.034)GAS(0.057)S(0.057)GT(0.001)GS(0.001)AS(0.008)AT(0.017)HGGGS(0.615)PPGT(0.21)R;APPQTHLPS(0.001)GAS(0.003)S(0.002)GT(0.001)GS(0.001)AS(0.009)AT(0.261)HGGGS(0.664)PPGT(0.057)R 91.853 2.7940000000000003e-07 64776000.0 2098.34 2549.0 2142.7 2147.02 3612.8999999999996 2335.3 2973.02 2133.31 723.5899999999999 1324.4699999999998 True False 2147.227239341115 2250.5618950020485 1851.7331090086116 1772.0832615568988 3286.1138329093014 2311.809002282748 2748.7627078078663 2076.727688832518 1227.8793810773861 1494.4786259303096 1.4367734687436369 1.5059177534915087 1.2390495768087093 1.1857535001236843 2.1988362870453924 1.546900010593094 1.8392787023613453 1.389600127295069 0.8216105334481006 1.0 10.545426548366047 -8.139443595220227 4.3200330240691835 0.9173917443490374 1.5619674150898222 0.46195051257471464 0.27728790675120624 0.21308062633883243 6.2797193064354495 0.21640338737570466 0.07533221870573115 7.253646800209503e-09 8.139443595220227 0.6445756707407848 APPQTHLPSGASSGTGSASATHGGGS(ph)PPGTR ddPTM_A459_Selumetinib_30min_R2 5 APPQTHLPSGASSGTGSASATHGGGSPPGTR 31 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;A0A0G2JJR8;A0A1B0GX79;F6X9W3;F6VEM6;F6U341;F6TC96;F6S6P2;X6REW1;A0A0G2JJM1;F6XTU0;F6U1F2;F6UR09;F6WML8 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 APPQTHLPSGASSGTGSASATHGGGS(0.955)PPGT(0.045)R;APPQTHLPSGASSGTGSAS(0.015)AT(0.174)HGGGS(0.764)PPGT(0.047)R;APPQTHLPSGASS(0.001)GTGS(0.003)AS(0.023)AT(0.061)HGGGS(0.829)PPGT(0.082)R;APPQTHLPS(0.001)GAS(0.048)S(0.003)GTGSAS(0.005)AT(0.256)HGGGS(0.628)PPGT(0.059)R;APPQTHLPSGASSGTGSAS(0.001)AT(0.011)HGGGS(0.782)PPGT(0.205)R 157.59 3.6385e-23 207997000.0 47248.2 30615.5 91877.3 138029.5 179316.3 99952.1 60878.7 77941.7 98405.6 129345.5 True False 44622.33419353049 32963.61040565172 85966.01454644074 119229.64398583146 156788.98328593845 113719.59450017479 63709.680178855524 78168.49744305687 118089.46968219511 125610.95933503142 0.3552423644382266 0.2624262292092738 0.6843830745464725 0.9491977819214036 1.2482110169045724 0.9053317887403455 0.5071984205528446 0.6223063485612326 0.9401207530564679 1.0 16.938602816759833 -5.4099729590216326 3.4637821410406757 0.8650550110713766 0.30858987422414597 0.5765397068935758 0.19344863083593908 0.1960639569379976 4.283051344009414 0.059562072881040075 0.1368903508736869 3.89069369315126e-06 5.4099729590216326 -0.5564651368472306 APPS(ph)PGSLAAPGR ddPTM_A459_Selumetinib_30min_R1 1 APPSPGSLAAPGR 13 0 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 APPS(0.915)PGS(0.085)LAAPGR 116.63 0.0037721 22124000.0 1313.1 1674.3 1355.9 1242.5 1352.6 1211.8 1388.2 1415.8 669.43 1215.6 True False 1343.692675152177 1478.272177639047 1171.7762274255724 1025.5206996136262 1230.2575688209251 1199.6103922263667 1283.4869563537682 1378.2483848334655 1135.9738167672783 1371.6341009467067 0.9796290965825036 1.077745279603896 0.8542921371062504 0.7476634613457104 0.8969283921796615 0.874584841101859 0.9357356713921745 1.0048221926548733 0.8281901244531797 1.0 10.4216799621258 -10.319696291812939 15.167472741097315 0.9999999980154605 0.9114866337940568 0.08149965397647585 0.08955786418136617 0.0 0.0 0.09306940535546594 0.02257264639964777 4.789649220822027e-11 10.319696291812939 -0.08851336422140366 APPS(ph)PGSLAAPGR ddPTM_A459_Selumetinib_30min_R2 4 APPSPGSLAAPGR 13 0 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 APPS(0.898)PGS(0.102)LAAPGR;APPS(0.943)PGS(0.057)LAAPGR;APPS(0.838)PGS(0.162)LAAPGR;APPS(0.824)PGS(0.176)LAAPGR 139.19 0.00094787 80630000.0 177416.0 165676.0 164866.0 175318.0 194749.0 135494.0 167191.0 146357.0 131355.0 150853.0 True False 167555.92897251982 178382.81646769648 154258.7010525288 151439.3859595812 170282.88954185 154157.0686079299 174965.7127826813 146782.87463929443 157629.67036535204 146497.48192683514 1.1437461365800257 1.217651075782898 1.052978515559536 1.0337337131515625 1.1623605218476993 1.052284766812034 1.1943257350325243 1.0019481066070597 1.0759889405066814 1.0 17.160516341521955 -1.5228787556764423 0.057305854501592424 0.8475634527345567 1.5950478023944534 0.27893038578358953 0.06421629011568741 513.0973917074348 2.2116652082148724 6.095673551216685 32.459973574293116 0.029999999281862536 1.5228787556764423 0.7474843496598967 APPSLPHSAS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 APPSLPHSASLR 12 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 APPSLPHS(0.188)AS(0.812)LR 94.339 0.013076 0.0 8907.0 6881.5 7935.4 9083.4 10925.0 6443.6 9315.2 7772.4 8393.5 6474.3 True False 8411.984597546068 7409.288922489992 7424.845003410252 7846.225250261 9552.503829260799 7331.147410823044 9748.375257718624 7795.016397209912 10072.434533984884 6287.370136748422 1.337917828056551 1.1784400729303623 1.1809142522107163 1.247934363590491 1.519316283517066 1.1660117428070527 1.5504694404328638 1.2397896461748925 1.6020107477232042 1.0 12.618240981567705 -6.0286137962492266 24.24876705076701 1.3616507008336072 1.2249253788653918 0.07965031767174535 0.17862390909506884 1008.5406345411136 854686.787670131 0.048354618603170973 0.06256918170355026 9.362378695117087e-07 6.0286137962492266 -0.1367253219682154 APPSPS(ph)TTSSNNNSSSSSNSGWDQLSK ddPTM_A459_Selumetinib_30min_R1 1 APPSPSTTSSNNNSSSSSNSGWDQLSK 27 0 E7EPF2;E7ETU5 E7EPF2 RBMS1 1 APPS(0.026)PS(0.199)T(0.199)T(0.199)S(0.199)S(0.175)NNNS(0.005)SSSSNSGWDQLSK 92.275 0.00024114 0.0 1376.5 1303.8 1488.9 1483.1 1257.3 1329.6 1521.1 1429.2 985.54 997.61 True False 1408.5697717972507 1151.1504898798244 1286.7155579422788 1224.1044262349847 1143.5774369943435 1316.2254311802083 1406.3622023553642 1391.2929733041312 1672.3893990063527 1125.6629610442942 1.2513246153986444 1.022642238145497 1.1430735508509346 1.0874519892698298 1.0159146001689794 1.1692891004951664 1.2493634871406456 1.2359765058036627 1.485692837805423 1.0 10.136559214019083 -7.127331342637969 3.180297599385188 1.2637465048615486 1.1002511816351117 0.20256972012053587 0.12586693916558042 0.3518806411583194 6.707702824955443 0.04942018444703166 0.03720036359367522 7.458794765394656e-08 7.127331342637969 -0.1634953232264369 APQAGAHTPLTPQPGLAPQQQS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 APQAGAHTPLTPQPGLAPQQQSPK 24 0 O15063 O15063 KIAA0355 Uncharacterized protein KIAA0355 1 APQAGAHTPLTPQPGLAPQQQS(1)PK;APQAGAHTPLTPQPGLAPQQQS(1)PK 121.49 9.8855e-08 39394000.0 1776.5900000000001 2562.8999999999996 2528.2 3042.8 2245.3 2194.2200000000003 1819.0500000000002 1991.77 1479.1 2047.98 True False 1817.9810903576308 2262.834476540115 2184.8843264085367 2511.4321004300537 2042.2130114399126 2172.148138992356 1681.8375939744435 1938.9417894192334 2509.924670810214 2310.8581820145096 0.7867125315205586 0.9792182376884203 0.9454861156835881 1.0867962906493431 0.883746578364059 0.9399746621831929 0.72779784024145 0.839057024143708 1.0861439660577383 1.0 11.174213008603317 APQAGAHTPLTPQPGLAPQQQS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 APQAGAHTPLTPQPGLAPQQQSPK 24 0 O15063 O15063 KIAA0355 Uncharacterized protein KIAA0355 1 APQAGAHTPLTPQPGLAPQQQS(1)PK;APQAGAHTPLTPQPGLAPQQQS(1)PK;APQAGAHTPLTPQPGLAPQQQS(1)PK;APQAGAHTPLTPQPGLAPQQQS(1)PK 207.76 7.3793e-32 36770200.0 138393.0 131206.0 127168.0 123319.0 112199.0 92092.0 128623.0 119862.0 92283.0 117983.0 True False 130701.67109107366 141269.07830621558 118986.14933004978 106522.73946285927 98103.55854821346 104776.83707205835 134604.2243616394 120210.7785757776 110742.17860245753 114576.52423335177 1.1407369176680615 1.2329670432182123 1.0384862878866632 0.9297082467426766 0.8562273921698942 0.9144703749143679 1.1747975884440194 1.0491745964552988 0.9665346312732874 1.0 16.80595195272395 -5.403551116034789 4.52553417723814 0.9859752434822106 1.1848389898857246 0.4752771038824062 0.0836628362420344 0.20870975192267543 6.706380645941941 0.024901523615957995 0.05413044064413421 3.948652213643467e-06 5.403551116034789 0.198863746403514 APQFQES(ph)VGSFR ddPTM_A459_Selumetinib_30min_R1 1 APQFQESVGSFR 12 0 Q5VT52-2;Q5VT52-3;Q5VT52 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 APQFQES(0.5)VGS(0.5)FR 89.301 0.025967 7336500.0 486.98 501.52 403.75 559.55 482.84 575.46 591.23 539.47 286.08 386.33 True False 498.3256865018713 442.80180524967716 348.92296763999946 461.8350965543698 439.1672072523258 569.6713948758746 546.6330450979965 525.1615031544777 485.4568655434965 435.9192186728702 1.1431606250786415 1.0157886743276898 0.8004303382224679 1.0594511018816717 1.0074508955795616 1.3068278948797092 1.253977851130739 1.2047220692707705 1.1136395110576696 1.0 8.767916999965443 -6.688321327635412 9.260236764562395 1.1933337147501106 0.9968081167346161 0.3622929878712545 0.11169978463412172 0.32210543641663114 37.7566495639219 0.037316567123456414 0.037275155468637654 2.0496451175841356e-07 6.688321327635412 -0.19652559801549452 APQQQPPPQQPPPPQPPPQQPPPPPS(ph)YSPAR ddPTM_A459_Selumetinib_30min_R1 1 APQQQPPPQQPPPPQPPPQQPPPPPSYSPAR 31 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-3;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-5 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 APQQQPPPQQPPPPQPPPQQPPPPPS(0.601)Y(0.017)S(0.382)PAR 151.07 2.8838e-20 10936000.0 883.44 1233.6 1148.4 1182.9 1276.0 841.0 1030.9 1276.2 447.54 1027.4 True False 904.0224331250006 1089.1695385149185 992.4535877096602 976.3287207830653 1160.5860252960972 832.5403035669038 953.1383830176485 1242.3510303181731 759.4426929716736 1159.276797723468 0.7798158601123358 0.9395250044284309 0.8560971716665017 0.8421877524852844 1.001129348551787 0.7181548920860026 0.8221836104107111 1.0716603944440555 0.6551003991997689 1.0 10.179009360950467 -10.86936971014645 3.308781535422797 1.0009344553195254 0.8620147494852529 0.11615546620157491 0.11899265542760797 37186943.000512265 57354816.85792814 350027.2473957697 0.028053775666905617 1.350922048376578e-11 10.86936971014645 -0.1389197058342725 APQTS(ph)SSPPPVR ddPTM_A459_Selumetinib_30min_R1 2 APQTSSSPPPVR 12 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.026)S(0.434)S(0.106)S(0.434)PPPVR;APQT(0.147)S(0.342)S(0.342)S(0.169)PPPVR 113.99 0.005725399999999999 268440000.0 5493.5 7314.64 7379.8 8032.6 7311.509999999999 6172.81 6762.0199999999995 6006.86 4277.62 5480.01 True False 5621.487861509769 6458.23854831612 6377.663694339736 6629.857200576592 6650.1852114519315 6110.717135863042 6251.955387266464 5847.538559768856 7258.808714996404 6183.422663317672 0.9091223692112288 1.0444439754423964 1.031413190007918 1.072198612575416 1.0754861140098453 0.9882418635417006 1.0110832992794352 0.9456799054767187 1.1739143691500042 1.0 12.59418990799154 -4.759107556091817 24.877983304191094 1.035983974208625 0.9091221931894737 0.3029209914852736 0.058598807814436875 73.83245188609996 787523.6161003832 0.014014769932359696 0.09087446836151837 1.7413755560448683e-05 4.759107556091817 -0.12686178101915124 APQTS(ph)SSPPPVR ddPTM_A459_Selumetinib_30min_R2 2 APQTSSSPPPVR 12 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.022)S(0.326)S(0.326)S(0.326)PPPVR;APQT(0.106)S(0.507)S(0.255)S(0.132)PPPVR 138.42 0.0033444000000000004 4438200.0 29219.0 28414.0 29513.0 35814.0 34307.0 25561.0 23168.0 28733.0 24945.9 27336.0 True False 27595.1249529245 30593.26243458993 27614.165711324786 30936.071417404004 29997.04795152862 29081.795730344515 24245.35790652108 28816.608272995796 29935.777046682986 26546.738652542335 1.0394920940799544 1.1524301660934937 1.0402093482274224 1.1653435784452306 1.1299711178893102 1.095494106111577 0.9133083435919216 1.08550465087869 1.1276630790131386 1.0 14.6962470119984 -7.027337437966629 24.98067851606836 1.0338382357843678 1.10828938346745 0.22909213241231108 0.06495124822279852 1119.4134078871143 1022905.7294850157 0.024705610572947935 0.019188260628528516 9.389934482736138e-08 7.027337437966629 0.07445114768308225 APQTSS(ph)SPPPVR ddPTM_A459_Selumetinib_30min_R2 1 APQTSSSPPPVR 12 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.011)S(0.128)S(0.431)S(0.431)PPPVR 140.33 0.0010841 80827000.0 17740.0 19031.0 19684.0 19267.0 22672.0 13875.0 15248.0 15287.0 14660.0 18718.0 True False 16754.08181884665 20490.616505690192 18417.552870318756 16642.80136257114 19823.740669748357 15786.155305290473 15957.062213338793 15331.482639100905 17592.409634624222 18177.562704795426 0.9216902227726468 1.1272477415404298 1.0132025491767396 0.9155683648490784 1.0905609839826684 0.868441801668269 0.8778438821794936 0.8434289507391606 0.9678090468081931 1.0 14.14987115172009 -6.775781409038953 24.998917013425544 0.8996152284861492 1.0144904663879142 0.31095521886912747 0.0749868322027154 260.48543983170566 454037.1345286527 0.025562534281178006 0.022648005201560767 1.6757861276542838e-07 6.775781409038953 0.11487523790176501 APQTSSS(ph)PPPVR ddPTM_A459_Selumetinib_30min_R1 6 APQTSSSPPPVR 12 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.001)S(0.068)S(0.219)S(0.712)PPPVR;APQT(0.001)S(0.001)S(0.007)S(0.991)PPPVR;APQTSS(0.003)S(0.997)PPPVR;APQT(0.052)S(0.091)S(0.081)S(0.776)PPPVR;APQT(0.014)S(0.052)S(0.216)S(0.718)PPPVR;APQT(0.024)S(0.024)S(0.08)S(0.872)PPPVR 180.3 0.00010397 1506387700.0 17781.699999999997 20506.7 20228.4 21415.8 19771.7 17055.7 19752.0 18198.3 10418.949999999999 15890.0 True False 18195.979012834865 18105.766030693816 17481.49438664758 17675.93255435452 17983.35322597715 16884.135143336563 18262.09073757357 17715.62196759067 17680.19718000005 17929.636281707117 1.0148548875695536 1.009823386610826 0.9750055222527432 0.9858500349161327 1.0029959862780282 0.9416886588247618 1.0185421751251944 0.9880636555726009 0.9860878883549044 1.0 14.13005860172675 -5.148431795087065 6.0147377160216315 0.9868951030146872 1.0134413484837153 0.2178969836362754 0.01904342437526226 0.3264722210436943 14.970048920127738 0.004682188866514485 0.012866284895571439 7.105067446317109e-06 5.148431795087065 0.026546245469028062 APQTSSS(ph)PPPVR ddPTM_A459_Selumetinib_30min_R2 6 APQTSSSPPPVR 12 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.001)S(0.008)S(0.027)S(0.964)PPPVR;APQT(0.001)S(0.003)S(0.025)S(0.972)PPPVR;APQT(0.064)S(0.021)S(0.071)S(0.844)PPPVR;APQT(0.023)S(0.182)S(0.182)S(0.613)PPPVR;APQT(0.044)S(0.202)S(0.202)S(0.552)PPPVR;APQT(0.016)S(0.182)S(0.182)S(0.621)PPPVR 198.48 0.00010424 1665614000.0 741117.0 721727.0 807748.0 835315.0 847053.0 576318.0 637728.0 642677.0 557501.0 701554.0 True False 699928.6840664138 777081.1401819267 755778.3730895261 721543.6560012524 740638.6293901011 655700.5732060823 667383.6156340588 644547.0836690955 669016.7778794436 681298.3131638037 1.0273453941432713 1.1405886748395546 1.1093207754762417 1.0590715433457598 1.0870988744280514 0.962428000388184 0.9795762043426646 0.9460570666555106 0.9819733367204049 1.0 19.377927109217993 -6.7586975969296414 24.99672405406548 0.9709835582325286 1.08773650535555 0.7634614527227523 0.030756295908677327 32.661468104658475 297774.16380991176 0.010245495935404518 0.0098059099490206 1.7430201312007628e-07 6.7586975969296414 0.11675294712302153 APQTSSS(ph)PPPVRR ddPTM_A459_Selumetinib_30min_R1 2 APQTSSSPPPVRR 13 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.002)S(0.013)S(0.048)S(0.936)PPPVRR;APQT(0.009)S(0.156)S(0.156)S(0.679)PPPVRR 97.45 0.023026 158847000.0 3229.0 3184.8 3747.6 4761.1 3497.2 3086.3999999999996 2927.5 3260.3999999999996 1853.76 2493.1 True False 3304.229417459733 2811.9221354266483 3238.696504093279 3929.6632619158436 3180.8788774808086 3055.353618226984 2706.6763180562284 3173.923600728232 3145.6953267264826 2813.1136698504724 1.1745808400395585 0.9995764357350382 1.151285331554138 1.3969088075010918 1.1307324377154957 1.0861109705493655 0.9621638638584051 1.1282599898982888 1.1182254597247356 1.0 11.457952133658933 -6.712564114341327 3.9953801570680207 1.0597305935376435 1.1752659218812151 0.24024419640419103 0.10146777910552177 0.3746860368660524 12.393035711743691 0.03804218837684412 0.03674809275537719 1.9383664562569593e-07 6.712564114341327 0.11553532834357161 APQTSSS(ph)PPPVRR ddPTM_A459_Selumetinib_30min_R2 1 APQTSSSPPPVRR 13 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 APQT(0.001)SS(0.004)S(0.995)PPPVRR 99.973 0.020305 28172000.0 13792.0 15379.0 13558.0 17858.0 13388.0 10168.0 10761.0 11956.0 7279.9 12847.0 True False 13025.495853750466 16558.519848721 12685.693040834254 15425.70959323172 11706.079749761437 11568.549704086025 11261.407822516974 11990.789980577647 8736.083417401154 12476.073729485353 1.044038063270389 1.3272220257553777 1.0168017050791787 1.236423407532078 0.9382823477626498 0.9272588440019771 0.9026403712172928 0.9611028469829567 0.7002269790017924 1.0 13.606876363251724 -6.36268954513279 5.113537832859641 0.9001187608120613 1.157755204955622 0.5536577349505465 0.1107610289810013 0.16448220136511926 6.6289038910127545 0.032841738493243365 0.0373921290952902 4.338208838870662e-07 6.36268954513279 0.2576364441435606 APRPFGSVSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 APRPFGSVSSPK 12 1 Q96HC4;A0A0D9SFR4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 APRPFGSVS(0.194)S(0.806)PK 78.505 0.024098 48545000.0 92172.0 93424.0 93899.0 102670.0 85572.0 52079.0 80453.0 72988.0 41448.0 83036.0 True False 87049.44923375054 100589.3203944931 87857.640569501 88686.16888437117 74821.68033661378 59252.40952390799 84194.22391459512 73200.38299618613 49738.75815388162 80638.53492656213 1.0795018698321697 1.2474100687233496 1.0895242659047977 1.0997988612409446 0.9278650759807852 0.7347902535415533 1.0440941665330499 0.907759336933019 0.6168112825856636 1.0 16.299181807159798 -6.265219780139233 2.7394922690438857 0.8631259190641232 1.1439951715552379 0.5217622157396213 0.12214374166598732 0.2245478517976848 3.365862616204788 0.039524336078650385 0.04957228027544449 5.429754824378432e-07 6.265219780139233 0.2808692524911147 APRPSAPS(ph)PPPR ddPTM_A459_Selumetinib_30min_R1 4 APRPSAPSPPPR 12 1 Q8IV50 Q8IV50 LYSMD2 LysM and putative peptidoglycan-binding domain-containing protein 2 1 APRPS(0.002)APS(0.998)PPPR;APRPS(0.001)APS(0.999)PPPR;APRPS(0.031)APS(0.969)PPPR;APRPS(0.042)APS(0.958)PPPR 104.09 0.0055522 192533000.0 3489.54 3699.21 4597.219999999999 4763.99 3875.08 3486.5299999999997 3688.48 3729.24 2319.21 3203.1600000000003 True False 3570.839492537144 3266.1047734839285 3972.9427747218783 3932.0485776678634 3524.57969820094 3451.458673715953 3410.2549839877133 3630.3284409212847 3935.529981603512 3614.316787420578 0.9879708123441879 0.903657583322917 1.0992237284096065 1.0879092257084748 0.9751717697983856 0.9549408302361754 0.9435406978870557 1.004430063672458 1.0888724517178179 1.0 11.819507245654675 -5.237286863977132 24.994690580358164 1.0152949724543638 0.94581420798128 0.20978229719166763 0.056602147958636745 1412.8933005698063 1462153.3110298584 0.015652593528468175 0.04137707226455894 5.79046093507189e-06 5.237286863977132 -0.06948076447308382 APRPSAPS(ph)PPPR ddPTM_A459_Selumetinib_30min_R2 3 APRPSAPSPPPR 12 1 Q8IV50 Q8IV50 LYSMD2 LysM and putative peptidoglycan-binding domain-containing protein 2 1 APRPS(0.003)APS(0.997)PPPR;APRPS(0.003)APS(0.997)PPPR;APRPS(0.075)APS(0.925)PPPR 113.52 0.003256800000000001 144836000.0 61690.0 50220.0 58865.0 70632.0 69585.0 61030.0 65754.0 58219.0 51923.0 51152.0 True False 58261.51676463644 54071.71251724881 55077.68998736607 61011.79975300378 60843.11020220719 69436.32852482 68811.69128907923 58388.407651325724 62309.0508498358 49675.10885114306 1.1728513155194789 1.0885071772923671 1.1087583150026394 1.2282167299488436 1.224820873257274 1.397809287804353 1.3852348365311298 1.1754057313954365 1.254331440652737 1.0 15.600235508349654 -5.879206821056559 3.2105953519914125 1.261769562842534 1.1190921838993937 0.17458638954891448 0.10741071993155679 0.3499677807416422 7.146814163862044 0.03138272806123896 0.049970857740100516 1.3206665525112571e-06 5.879206821056559 -0.14267737894314036 APS(ph)ASPLALHASR ddPTM_A459_Selumetinib_30min_R2 2 APSASPLALHASR 13 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 APS(0.783)AS(0.217)PLALHASR;APS(0.596)AS(0.404)PLALHASR 84.40299999999998 0.019307 18571500.0 21167.7 21522.9 30950.0 43919.0 47089.0 24247.0 18825.4 22414.0 22106.0 33183.0 True False 19991.283975016948 23173.637222968817 28958.71069581209 37937.156435499164 41173.25883899881 27586.804157648898 19700.818401822427 22479.221029162538 26527.817693247132 32224.920570211907 0.6203672071575719 0.7191216242869526 0.898643353758363 1.1772614412762132 1.277683795970581 0.8560705090813973 0.6113535131575617 0.6975725814493363 0.8232081638633715 1.0 14.975889182105263 -7.001304928604296 24.989744869862758 0.7543856473329872 0.9504006315260726 0.10807824962970725 0.20308121966370182 100.62596553266076 1927055.089006095 0.08018366157732225 0.06977360731760203 9.969998004690397e-08 7.001304928604296 0.19601498419308538 APS(ph)DSSLGTPSDGRPELR ddPTM_A459_Selumetinib_30min_R1 2 APSDSSLGTPSDGRPELR 18 1 Q15642;M0R2H7;M0R0F9;W4VSQ9;Q15642-5;Q15642-4;Q15642-2;Q15642-3 Q15642 TRIP10 Cdc42-interacting protein 4 1 APS(0.857)DS(0.099)S(0.045)LGTPSDGRPELR;APS(0.856)DS(0.125)S(0.019)LGTPSDGRPELR 162.81 3.6738e-06 235030000.0 2833.1 2483.9700000000003 3127.6 3406.4 3297.5 2384.5 2835.5 2370.27 1765.04 2037.44 True False 2899.1057177470325 2193.145637633677 2702.889098677057 2811.5361860473686 2999.2417072209105 2360.5140949527736 2621.6159521258546 2307.402739877962 2995.143966578905 2298.9652703462148 1.2610480702522484 0.9539707562887186 1.1756980992888217 1.2229572244142526 1.3046050525022663 1.026772402959045 1.1403460443450066 1.0036701161346717 1.3028226242529746 1.0 11.16676895659998 -6.801009590801978 24.999993036722074 1.097803206665755 1.172637670295326 0.11799895217850265 0.11954216091419817 429.9546654604944 271637.1924151074 0.04186052985135187 0.036918050443607464 1.581213119947202e-07 6.801009590801978 0.07483446362957102 APS(ph)DSSLGTPSDGRPELR ddPTM_A459_Selumetinib_30min_R2 2 APSDSSLGTPSDGRPELR 18 1 Q15642;M0R2H7;M0R0F9;W4VSQ9;Q15642-5;Q15642-4;Q15642-2;Q15642-3 Q15642 TRIP10 Cdc42-interacting protein 4 1 APS(0.374)DS(0.252)S(0.374)LGT(0.001)PSDGRPELR;APS(0.565)DS(0.363)S(0.071)LGT(0.001)PSDGRPELR 158.29 8.831799999999999e-05 124437000.0 335080.0 338070.0 345910.0 377890.0 397300.0 308830.0 305980.0 331490.0 291340.0 375260.0 True False 316457.5950315182 363998.88193361746 323654.52719833143 326420.7301033897 347387.62209293555 351368.52922038623 320208.6762878676 332454.5810188767 349616.1407197428 364425.2687574277 0.8683744574313857 0.9988299745918715 0.8881231762602212 0.8957137665463727 0.9532478998435399 0.9641716953888496 0.8786676000258589 0.9122709359656626 0.9593630592955883 1.0 18.475263471576575 -8.525392036665037 3.505930779276256 0.9997692262253729 0.9221129151709397 0.2963232264647607 0.039210480736287245 0.2651656768909313 8.7961090239179 0.036807008586147605 0.009714492030863301 2.9826889366263865e-09 8.525392036665037 -0.07765631105443316 APS(ph)EEEALEK ddPTM_A459_Selumetinib_30min_R1 1 APSEEEALEK 10 0 Q14147 Q14147 DHX34 Probable ATP-dependent RNA helicase DHX34 1 APS(1)EEEALEK 126.34 0.0034724000000000005 3384000.0 939.82 1674.8 767.54 1005.0 1161.4 1100.2 1288.7 1325.5 683.27 1439.9 True False 961.7159774286184 1478.7136374066029 663.3122837954309 829.4956161864748 1056.3515750618242 1089.1329869016738 1191.4923214616774 1290.343434169204 1159.4592859336722 1624.7251908137243 0.5919253193501323 0.9101315384086626 0.40826121706355695 0.5105451807336302 0.6501724605702476 0.6703490492174831 0.7333500632589642 0.7941918063835466 0.7136340917770658 1.0 10.665980003186045 -8.645488565300107 0.5226894700582416 1.0034284271906317 0.6140539051167162 0.4389142564011447 0.12541761893670791 1.152368002961508 0.7263790354621468 0.15699058200465835 0.06859633539753315 2.262098098602262e-09 8.645488565300107 -0.38937452207391554 APS(ph)EEEALEK ddPTM_A459_Selumetinib_30min_R2 1 APSEEEALEK 10 0 Q14147 Q14147 DHX34 Probable ATP-dependent RNA helicase DHX34 1 APS(1)EEEALEK 125.97 0.0035357 4058500.0 18525.0 10508.0 14252.0 14910.0 16443.0 13966.0 16143.0 18329.0 15003.0 12704.0 True False 17495.45466145065 11313.929811454609 13335.041836404325 12879.232278815372 14377.283337714905 15889.689729274734 16893.68148674765 18382.334355470706 18004.01921884497 12337.202511043966 1.4181054939958342 0.9170579636126304 1.080880517643049 1.0439345765205843 1.165360082631756 1.287949169599078 1.3693283766416928 1.489992106315454 1.459327526052053 1.0 13.59072767671209 -6.799008589250848 2.329252592036469 1.3680904500125646 1.0986737757236107 0.23536978520916207 0.17263009658997341 0.34262718628543043 3.811788608155235 0.06485304328325757 0.05848380036042114 1.5885153314553778e-07 6.799008589250848 -0.2694166742889539 APS(ph)EIDPR ddPTM_A459_Selumetinib_30min_R1 1 APSEIDPR 8 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 1 APS(1)EIDPR 114.89 0.01011 18511000.0 4773.4 5195.3 4854.4 5398.4 4884.3 4151.1 4612.9 3638.9 2593.5 3718.4 True False 4884.610932580456 4587.031860770558 4195.199143310497 4455.67078051847 4442.515927393202 4109.343702897237 4264.945239132904 3542.384551186962 4400.980078254538 4195.692860283184 1.164196497512636 1.093271603408301 0.9998823276657448 1.0619630485101188 1.0588277253195695 0.9794195713887124 1.0165055882677374 0.8442907212583413 1.0489280852549103 1.0 12.034693356008036 -1.5228787452803385 0.3536368499195433 0.9668056069144709 3.299576804203652 0.478305017564009 0.057398407135167744 52.47784037469197 0.7366066964029695 0.047777845141936226 81.91011884131531 0.029999999999999933 1.5228787452803385 2.332771197289181 APS(ph)EIDPR ddPTM_A459_Selumetinib_30min_R2 1 APSEIDPR 8 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 1 APS(1)EIDPR 85.86200000000002 0.03468 21074000.0 87716.0 92536.0 93874.0 98979.0 103980.0 84002.0 93169.0 86729.0 78354.0 82023.0 True False 82841.09587496928 99633.21364986322 87834.24904228312 85497.88945170134 90917.10280700588 95572.5130057666 97501.54311087121 86981.36703124123 94026.98939368 79654.78286865246 1.040001527737147 1.2508126952546514 1.102686441153424 1.0733553764459307 1.1413891235749716 1.1998339530139934 1.2240513325062645 1.0919792120288623 1.1804311807456276 1.0 16.281473370474174 -10.67214315341371 4.714059564919327 0.9999856492824992 1.146992078275993 0.30741020024658317 0.06520538802034383 7438232.0096673 16869663.81608731 684.3886074986124 0.015449671801523509 2.1274376781836265e-11 10.67214315341371 0.1470064289934938 APS(ph)IDGKEELDLAEK ddPTM_A459_Selumetinib_30min_R1 2 APSIDGKEELDLAEK 15 1 H7C128;H7C179;H7C127;Q9H0E9-3;Q9H0E9-4;Q9H0E9-2;H0YA84;H0YAH7;B5MCW3;Q9H0E9 H7C128 BRD8 Bromodomain-containing protein 8 1 APS(1)IDGKEELDLAEK;APS(1)IDGKEELDLAEK 77.795 0.018808 52504000.0 8841.2 9701.7 8317.8 8076.2 8682.6 9456.7 10044.7 9111.8 6075.4 9398.1 True False 9047.182758019508 8565.820453802036 7188.288446404916 6665.843279049952 7897.260363037539 9361.574183996598 9287.02019196564 8870.125464702343 10309.510070340326 10604.43768024617 0.853150636631351 0.8077581020404648 0.6778566354154902 0.6285899809159152 0.7447127892267658 0.8827977933648697 0.8757673411825879 0.8364541083800714 0.9721882839242639 1.0 13.372380500896085 -6.783106250404248 4.3839841838644995 0.9033938800906262 0.7349808719787075 0.5780230229234333 0.07292195643213222 0.17045017345751884 7.59129324388426 0.02783166568932605 0.025562238857868885 1.647759216933022e-07 6.783106250404248 -0.16841300811191862 APS(ph)LTDLVK ddPTM_A459_Selumetinib_30min_R1 1 APSLTDLVK 9 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 APS(0.999)LT(0.001)DLVK 97.734 0.020328 32591000.0 2439.1 2879.4 3099.9 3694.9 3042.2 3109.0 2655.8 2612.0 1495.1 2651.8 True False 2495.9262843375786 2542.278509403257 2678.950606531849 3049.65507686309 2767.0335471440335 3077.7262827461395 2455.4708678031548 2542.7212750282624 2537.07550221645 2992.1843607193796 0.834148562870474 0.8496396621737717 0.8953160245406059 1.0192069435620916 0.9247536961521932 1.0285884530210545 0.8206282006008518 0.8497876362193614 0.8479007963287688 1.0 11.54698335296968 -5.329274022844817 3.8682331122636815 0.9226922501039438 0.8404527461047425 0.18775442869488324 0.06940094337764265 0.4082709577742391 11.943993669644707 0.01975003013909557 0.04671111968306548 4.685176725238934e-06 5.329274022844817 -0.08223950399920132 APS(ph)LTDLVK ddPTM_A459_Selumetinib_30min_R2 3 APSLTDLVK 9 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 APS(0.999)LT(0.001)DLVK;APS(0.997)LT(0.003)DLVK;APS(0.999)LT(0.001)DLVK 107.06 0.01281 14133300.0 103308.0 94120.0 117510.0 125193.0 123646.0 84300.0 83175.0 78835.0 68677.5 113999.0 True False 97566.55493469068 101338.7013565004 109949.53453521417 108141.49743002896 108112.48407073518 95911.55980079185 87042.8023081358 79064.39679816322 82414.91900967988 110707.5526650269 0.8812998985706281 0.9153729706511147 0.9931529682341882 0.9768213173064879 0.9765592452202088 0.8663506462923628 0.7862408680598815 0.7141734677975595 0.7444380895949043 1.0 16.7563941231208 -7.010799139768413 3.233857549742543 0.7885430291049851 0.9504254637834278 0.3930611117931976 0.0785699817134813 0.2190641776736432 4.7380395942276134 0.03047002773482394 0.024586114907694388 9.754406725487687e-08 7.010799139768413 0.16188243467844277 APS(ph)LTNDEVEEFR ddPTM_A459_Selumetinib_30min_R1 1 APSLTNDEVEEFR 13 0 Q13206;A0A3B3ISR7;E9PIF2 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 APS(0.99)LT(0.01)NDEVEEFR 128.74 0.0017957 7270900.0 538.53 903.66 1022.9 834.76 977.71 484.36 665.26 716.29 363.86 756.61 True False 551.0767012030318 797.8590670998634 883.9957983875051 688.9848363858916 889.2763031287203 479.48777816369295 615.0789025961009 697.2916623621722 617.4438447170606 853.7282635055014 0.6454942687972526 0.9345585723304591 1.0354533593133275 0.8070306042778116 1.0416385882285948 0.561639808192438 0.7204621527586773 0.816760662812095 0.7232322872640632 1.0 9.737633131661168 -6.75047313013149 24.999390955266637 0.7502191950946923 0.8983093296676793 0.15592358356240854 0.14727773962892604 360.19251575134496 821117.4499918754 0.04749128638445014 0.047053424714904576 1.7763431675223098e-07 6.75047313013149 0.14809013457298703 APS(ph)PAPSSVPLGSEKPSNVSQDR ddPTM_A459_Selumetinib_30min_R2 1 APSPAPSSVPLGSEKPSNVSQDR 23 1 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 APS(0.997)PAPS(0.001)S(0.001)VPLGSEKPSNVSQDR 105.71 0.00038061 0.0 7743.1 8845.0 9595.3 9181.0 6717.6 7762.7 5667.6 6102.3 6561.2 5356.2 True False 7312.769500085206 9523.383058842406 8977.948844572722 7930.531961891614 5873.675031894035 8831.941462225474 5931.154630136342 6120.056682709852 7873.62333524532 5201.552588921105 1.405882065993301 1.8308731664323568 1.7260132798993597 1.5246470791784397 1.1292157353949468 1.6979433181232868 1.1402662048960597 1.1765826795147833 1.513706379132937 1.0 12.344726595995217 -6.706440926517071 0.2248500811908734 0.9755412017274327 1.8980419476578918 0.38722897248899435 0.2154899312453753 4.5642339466849045 0.5164103663490003 0.5227351542247487 1.321713001973322 1.965889366050068e-07 6.706440926517071 0.922500745930459 APS(ph)PEPAAPR ddPTM_A459_Selumetinib_30min_R1 2 APSPEPAAPR 10 0 P20749 P20749 BCL3 B-cell lymphoma 3 protein 1 APS(1)PEPAAPR;APS(1)PEPAAPR 158.08 0.00048138 223090000.0 5757.3 6460.5 6376.2 7298.6 7072.4 5470.5 6819.7 6292.200000000001 3341.8 5541.6 True False 5891.433888244329 5704.101656595032 5510.347061959538 6024.036521690154 6432.7026687336365 5415.471736816588 6305.284538428034 6125.310416053916 5670.790524584932 6252.918339755073 0.9421894814757962 0.9122303133769154 0.8812440467878201 0.9633960007745943 1.0287520673083994 0.8660710795447094 1.0083746813611854 0.9795922612822486 0.9069030197517431 1.0 12.610313961098777 -5.787790258121637 22.98076621007934 0.9642524529076013 0.9119222200755726 0.20735383240884164 0.04733581624698516 135.48197341218824 118153.83621516792 0.013047305793456128 0.01936308604713149 1.6300830887898971e-06 5.787790258121637 -0.052330232832028756 APS(ph)PEPAAPR ddPTM_A459_Selumetinib_30min_R2 2 APSPEPAAPR 10 0 P20749 P20749 BCL3 B-cell lymphoma 3 protein 1 APS(1)PEPAAPR;APS(1)PEPAAPR 96.171 0.021983000000000003 60063000.0 147580.0 110800.0 148430.0 169708.0 160762.0 126137.0 139032.0 165023.0 113161.0 137484.0 True False 139378.0944095484 119298.00372184698 138880.17539836472 146593.4776373711 140565.64032948518 143511.22679231878 145497.26348668156 165503.18960897185 135796.36198251785 133514.47969366895 1.0439174442302641 0.8935210922108241 1.0401881183000274 1.0979593971658368 1.0528119545684795 1.0748738797588548 1.0897489457361142 1.2395898181882348 1.0170908975122726 1.0 17.02663668563396 -5.501511173988911 5.6079033594421 1.0893988689255767 0.9672208723252176 0.28722178097720064 0.06982709875938811 0.18869332071442024 18.99659150928372 0.01819750323929587 0.03616399139260101 3.1512932993461347e-06 5.501511173988911 -0.1221779966003591 APS(ph)PGAYK ddPTM_A459_Selumetinib_30min_R2 1 APSPGAYK 8 0 P54259 P54259 ATN1 Atrophin-1 1 APS(1)PGAYK 82.831 0.040368 7949400.0 76804.0 78064.0 76148.0 89168.0 73081.0 64664.0 73805.0 79208.0 71076.0 71308.0 True False 72535.54115077223 84051.25778467767 71248.72058367378 77023.16457662045 63899.91142757054 73570.8790386525 77237.07874183304 79438.48216640965 85293.18602936906 69249.15275956564 1.0474574526942877 1.2137514241727292 1.0288749788903655 1.1122614719063253 0.9227536927337182 1.0624083632343053 1.1153505229154448 1.1471401309734657 1.2316856254618538 1.0 16.079508799923545 -7.421824697456933 3.7059708288399174 1.1406337092665737 1.0657704118105975 0.09448122104130419 0.08624221415235092 0.5214020459349034 13.02798921391004 0.039719728650511064 0.02511374937650554 3.785953735309133e-08 7.421824697456933 -0.0748632974559762 APS(ph)PLGPTRDPVATFLETCR ddPTM_A459_Selumetinib_30min_R2 1 APSPLGPTRDPVATFLETCR 20 1 I3L2L9;E7EVV8;Q0VG06-3;Q0VG06 I3L2L9 C17orf70;FAAP100 Fanconi anemia-associated protein of 100 kDa 1 APS(0.914)PLGPT(0.086)RDPVAT(0.001)FLETCR 62.916 0.012014 6329300.0 6127.3 5006.6 6531.7 5327.4 5584.1 5074.9 5209.5 7145.4 5693.1 8353.1 True False 5786.769195525319 5390.590121243681 6111.457533177247 4601.798929722404 4882.575435512608 5773.921409644586 5451.752072428418 7166.191931015351 6831.879078504718 8111.924299039779 0.7133657788461252 0.6645266798017054 0.7533918350175765 0.5672881994555997 0.6019010108477671 0.7117819640314017 0.6720664384249432 0.8834145471332399 0.8422020258884094 1.0 12.985828473750198 -8.030555125933882 1.1461642200187359 0.9751049757918513 0.6597424897339412 0.7588584680872108 0.0620177948627929 0.22766415332895765 0.5491400754693841 0.05724251295935043 0.01997140580234272 9.320621541761919e-09 8.030555125933882 -0.31536248605791006 APS(ph)PPEAALQPAPTEPR ddPTM_A459_Selumetinib_30min_R1 1 APSPPEAALQPAPTEPR 17 0 Q9NVR5-2;Q9NVR5 Q9NVR5-2 DNAAF2 Protein kintoun 1 APS(0.998)PPEAALQPAPT(0.002)EPR 95.9 0.0062088 7223800.0 1783.6 1330.6 1394.4 1689.7 1649.9 1169.2 1325.6 1132.7 639.69 1054.1 True False 1825.1544097185451 1174.812733420842 1205.048138890936 1394.6256145972989 1500.6668363135043 1157.438909548661 1225.6089247533164 1102.6571164718653 1085.507208890937 1189.4040028034904 1.5345117432063087 0.9877322849525848 1.013152920328645 1.1725415513232593 1.2616964738443375 0.9731251171347282 1.0304395494419802 0.9270669292123132 0.9126480206324655 1.0 10.216023120722596 -6.77967309735718 24.32201403805689 0.9679589626831825 1.1712406263042212 0.3734760628634167 0.14439719616741695 220.46233105109823 294072.9545130417 0.051213209102407065 0.04526185727451205 1.6608365838766728e-07 6.77967309735718 0.20328166362103872 APS(ph)PPEAALQPAPTEPR ddPTM_A459_Selumetinib_30min_R2 1 APSPPEAALQPAPTEPR 17 0 Q9NVR5-2;Q9NVR5 Q9NVR5-2 DNAAF2 Protein kintoun 1 APS(1)PPEAALQPAPTEPR 74.53699999999998 0.023091 4063500.0 6662.5 4696.6 6286.1 5705.8 6194.0 6657.4 7074.9 6784.6 7275.6 7146.4 True False 6292.224922100667 5056.81411805079 5881.6591697881895 4928.660196945993 5415.854344937426 7574.396420139884 7403.896868648393 6804.342062749006 8730.923297249114 6940.06486342291 0.9066521777430878 0.7286407573367719 0.8474934003552376 0.7101749470559168 0.7803751768202166 1.091401387335754 1.0668339582343207 0.9804435832596866 1.2580463538986195 1.0 12.76073343128425 -6.760812708704671 24.999917683858484 1.0773408702571958 0.7892398813758149 0.7283169352403891 0.08689907612504018 8.442812570098303 336816.5598863646 0.028105134550058822 0.026518045034120245 1.7345518691639486e-07 6.760812708704671 -0.2881009888813809 APS(ph)PPLSQVFQTR ddPTM_A459_Selumetinib_30min_R1 2 APSPPLSQVFQTR 13 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 APS(1)PPLSQVFQTR;APS(0.983)PPLS(0.017)QVFQTR 139.64 0.00092431 300810000.0 1574.8000000000002 1884.03 1967.23 2305.37 1793.3000000000002 1604.94 1602.73 1587.37 889.62 1116.6399999999999 True False 1611.48977597262 1663.4468917382162 1700.0909712208932 1902.7804066545386 1631.0963316328312 1588.7957607689266 1481.8347857346746 1545.2677910955638 1509.6201647259702 1259.9716209946773 1.2789889463545525 1.320225681293534 1.3493089391003634 1.5101771936358372 1.294550055298207 1.2609774175029917 1.176085842762751 1.2264306317277693 1.1981382275373864 1.0 10.299175524171943 -7.010042608358012 1.5822621982186367 1.1598519041819455 1.3612910321756428 0.5849126877508422 0.08029413951068094 0.30901838659429065 1.5631253385109485 0.04058152007520213 0.030120201243269733 9.771413495307454e-08 7.010042608358012 0.20143912799369734 APS(ph)PPLSQVFQTR ddPTM_A459_Selumetinib_30min_R2 4 APSPPLSQVFQTR 13 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 APS(1)PPLSQVFQTR;APS(0.998)PPLS(0.002)QVFQTR;APS(0.818)PPLS(0.182)QVFQTR;APS(0.992)PPLS(0.008)QVFQTR 137.73 0.0010257 223372000.0 290825.0 261125.0 305887.0 322437.0 315649.0 224186.0 235274.0 275108.0 202255.0 237875.0 True False 274662.1107647172 281152.44785078824 286206.5634445846 278520.52436515014 275994.35068213654 255065.58654211558 246214.7071865864 275908.51873341907 242711.65147687047 231006.93067652587 1.1889777936979768 1.2170736480823603 1.2389522799441617 1.205680381750782 1.1947448930378872 1.1041469006801294 1.0658325551771244 1.1943733373080825 1.050668266818083 1.0 17.81757661050524 -6.737081761223477 3.4458552568148195 1.0923103495993298 1.2135379430186495 0.6361244073211636 0.047650295825021165 0.16384511118775005 4.06645930814273 0.0164929795203518 0.015613432482807908 1.8319694993429375e-07 6.737081761223477 0.12122759341931966 APS(ph)PPPTASNSSNSQSEK ddPTM_A459_Selumetinib_30min_R2 2 APSPPPTASNSSNSQSEK 18 0 Q8N108-17;Q8N108;Q8N108-13;Q8N108-12;Q8N108-19;Q8N108-16;Q8N108-14;Q8N108-18;Q8N108-15 Q8N108-17 MIER1 Mesoderm induction early response protein 1 1 APS(0.999)PPPT(0.001)ASNSSNSQSEK;APS(0.995)PPPT(0.005)ASNSSNSQSEK 161.1 1.1189e-05 10536700.0 39919.3 31849.6 35298.5 36443.7 33195.9 31224.9 38624.7 38756.8 29832.7 27110.0 True False 37700.745115619255 34292.361907394785 33027.43294010091 31480.005191110915 29025.53426688865 35525.84654357944 40420.82508339109 38869.57587146636 35800.07359528334 26327.26385976086 1.4320039224904741 1.3025418095120758 1.2544954582455006 1.1957188319605674 1.1024895872773124 1.3493937969709753 1.5353219118668509 1.4764001332806722 1.3598098832443017 1.0 14.684269972294206 -6.98550662700681 24.988707827898388 1.391122280312745 1.2533193975155221 0.03750825732850349 0.15570574669884354 457.27074820054133 788399.1887062708 0.053939801089278795 0.047551267635945915 1.033935323787415e-07 6.98550662700681 -0.13780288279722286 APS(ph)PPVEHPR ddPTM_A459_Selumetinib_30min_R1 6 APSPPVEHPR 10 0 Q86WR7;Q86WR7-2 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 APS(1)PPVEHPR;APS(1)PPVEHPR;APS(1)PPVEHPR;APS(1)PPVEHPR;APS(1)PPVEHPR;APS(1)PPVEHPR 128.68 0.0020357 403846700.0 6661.91 8257.55 9230.240000000002 9821.67 6790.67 6892.37 6216.02 6430.06 6922.38 7145.2 True False 6817.119541179679 7290.752207169154 7976.824106079075 8106.499710079808 6176.45509749016 6823.039015571255 5747.14060685359 6259.513921021522 11746.77326936867 8062.356020141834 0.8455493064494752 0.9042954924038313 0.9893912010522633 1.0054752841263388 0.7660856308081399 0.8462835179351486 0.7128363709684561 0.7763876843671564 1.4569901453151184 1.0 12.976985776255002 -8.246916035038991 24.99470428986755 1.2284950970887025 0.8587760235350053 0.5496002741671251 0.13493769556782836 511.74107529222636 880711.2204867784 0.09189657981959713 0.03439262697283403 5.663487743255941e-09 8.246916035038991 -0.36971907355369726 APS(ph)PPVEHPR ddPTM_A459_Selumetinib_30min_R2 4 APSPPVEHPR 10 0 Q86WR7;Q86WR7-2 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 APS(1)PPVEHPR;APS(1)PPVEHPR;APS(1)PPVEHPR;APS(1)PPVEHPR 120.55 0.0022977 199588500.0 33355.2 29517.1 34478.8 37687.2 53399.1 28898.9 30853.100000000002 36791.7 30812.5 34763.5 True False 31501.45151544499 31780.96665756439 32260.47154567904 32554.138345953783 46690.62766398905 32879.46115690518 32287.830284257816 36898.75775580615 36975.86097318273 33759.78742857976 0.9331057425076396 0.941385271598595 0.9555887048734361 0.9642874207908869 1.3830249305557691 0.9739238206538786 0.9563990991520331 1.0929795643372169 1.0952634417917089 1.0 15.043018199569094 -6.032783922746691 24.99528064976451 1.0852448721993067 0.9459581798351367 0.25994130119331704 0.11196977359527982 908.7617296901043 692861.2039288775 0.03383190578013114 0.04371190611193322 9.272910695593941e-07 6.032783922746691 -0.1392866923641699 APS(ph)PSGLMSPSR ddPTM_A459_Selumetinib_30min_R2 1 APSPSGLMSPSR 12 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 APS(0.975)PS(0.025)GLMSPSR 109.6 0.0075714 15666000.0 62962.0 55702.0 65588.0 69847.0 74054.0 56053.0 53133.0 51835.0 54918.0 63272.0 True False 59462.8240968559 59974.16428984055 61368.13948681491 60333.71810720433 64750.67446884021 63773.79195152777 55603.78978104213 51985.83126825381 65903.13453712773 61445.17295960125 0.96773792362748 0.9760598172499595 0.99874630554239 0.9819114374838251 1.0537959509270525 1.0378975089460245 0.9049334081555975 0.8460523221642368 1.0725518598581776 1.0 15.907012058645728 APS(ph)PSINR ddPTM_A459_Selumetinib_30min_R1 1 APSPSINR 8 0 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 APS(0.5)PS(0.5)INR 122.94 0.0061569 21369000.0 5102.1 6042.9 6329.2 6075.3 6392.7 5070.0 5573.6 4730.9 3247.7 4807.6 True False 5220.969003041595 5335.394458732006 5469.7294038070195 5014.362902505164 5814.481413722856 5019.000403191682 5153.178864668897 4605.421163871057 5511.109697377004 5424.702289989627 0.9624434160517918 0.9835368235004482 1.0083003843179528 0.9243572521497309 1.0718526294894561 0.9252121378998808 0.9499468522315444 0.8489721495628588 1.0159285068135124 1.0 12.405328248663245 APS(ph)PTAEQPPGGGDSAR ddPTM_A459_Selumetinib_30min_R1 5 APSPTAEQPPGGGDSAR 17 0 Q15742;Q15742-2;Q15742-3 Q15742 NAB2 NGFI-A-binding protein 2 1 APS(0.908)PT(0.092)AEQPPGGGDSAR;APS(0.98)PT(0.02)AEQPPGGGDSAR;APS(0.983)PT(0.017)AEQPPGGGDSAR;APS(0.98)PT(0.02)AEQPPGGGDSAR;APS(0.942)PT(0.058)AEQPPGGGDSAR 135.79 0.00051562 60306700.0 4554.389999999999 4617.88 5600.1900000000005 5644.81 4939.8 4446.599999999999 4361.01 4110.13 2588.5699999999997 4088.67 True False 4660.498425699735 4077.216462805833 4839.714957641726 4659.049899707039 4492.9959621925245 4401.871241189768 4032.055504630706 4001.1160008161964 4392.614228327491 4613.490621518405 1.0101892055360586 0.8837595645667377 1.049035395253251 1.0098752293927151 0.9738821059343082 0.9541303109316849 0.8739706732737791 0.8672643620763096 0.9521238014095674 1.0 12.171643008583935 -6.981769291905339 3.6522970858241646 0.9120837084807604 0.984166330699752 0.21696011134480186 0.05351250072505234 0.3106115007290171 8.963350656210606 0.0203987888063318 0.016936999917607692 1.0428712815872093e-07 6.981769291905339 0.07208262221899164 APS(ph)PTAEQPPGGGDSAR ddPTM_A459_Selumetinib_30min_R2 3 APSPTAEQPPGGGDSAR 17 0 Q15742;Q15742-2;Q15742-3 Q15742 NAB2 NGFI-A-binding protein 2 1 APS(0.5)PT(0.5)AEQPPGGGDSAR;APS(0.983)PT(0.017)AEQPPGGGDSAR;APS(0.674)PT(0.326)AEQPPGGGDSAR 160.76 2.4407e-05 45024000.0 22094.5 18036.3 22171.100000000002 27856.0 26596.800000000003 17189.2 19571.2 14092.0 15416.4 21046.2 True False 20866.576141291298 19419.626214154807 20744.635564068492 24061.964745719713 23255.472205591173 19556.856271978326 20481.299579597096 14133.00538694381 18500.110770206065 20438.541521405346 1.0209425227058238 0.9501473573256963 1.0149763153277143 1.1772838448633698 1.1378244470739582 0.9568616357236827 1.0020920307912857 0.6914879602413054 0.9051580686826819 1.0 14.319004629890108 -7.568934802664977 12.64241575324668 0.8482134808464287 1.0422292982664103 0.39588391360633124 0.09756315020443551 0.9921443626961342 270.1921535732007 0.047188257079434234 0.027240664836956467 2.6981444539953766e-08 7.568934802664977 0.19401581741998164 APS(ph)PTSSAGEEGTK ddPTM_A459_Selumetinib_30min_R1 2 APSPTSSAGEEGTK 14 0 O94964-2;H0YDM2;O94964;O94964-3 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 APS(0.76)PT(0.079)S(0.144)S(0.018)AGEEGTK;APS(0.98)PT(0.014)S(0.004)S(0.001)AGEEGTK 157.35 0.00031398 19901300.0 4398.3 5671.0 3485.3 3802.6 3857.0 3873.1000000000004 4730.9 4111.0 2141.1 3995.5 True False 4500.771832398003 5007.036683623629 3012.0154033825147 3138.547293642473 3508.1350310086577 3834.140130493434 4374.044404130558 4001.962925590041 3633.290320243219 4508.361344465752 0.9983165697050737 1.1106112179251175 0.6680953839425317 0.6961614329106967 0.7781397192829443 0.8504509371681221 0.9702071484354121 0.8876757251285233 0.8059004242646326 1.0 12.138387436591206 -9.77559860536326 15.617432391329507 0.9999997655839488 0.8605299188804323 0.09121458129605309 0.1296973279284953 0.0 0.0 0.13711081754820356 0.033254257833296164 1.676491649732202e-10 9.77559860536326 -0.13946984670351648 APS(ph)PTSSAGEEGTK ddPTM_A459_Selumetinib_30min_R2 4 APSPTSSAGEEGTK 14 0 O94964-2;H0YDM2;O94964;O94964-3 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 APS(0.968)PT(0.027)S(0.005)S(0.001)AGEEGTK;APS(0.659)PT(0.254)S(0.081)S(0.006)AGEEGTK;APS(0.983)PT(0.017)SSAGEEGTK;APS(0.994)PT(0.005)SSAGEEGTK 197.06 6.9275e-05 37778200.0 169220.0 128511.0 145276.0 153485.0 162912.0 132954.0 160437.0 173348.0 148030.0 139545.0 True False 159815.42984133202 138367.38047200604 135929.1003245495 132580.07822360683 142445.53810824137 151267.2066637543 167897.63839988422 173852.41398069388 177640.13630378025 135515.97326854762 1.1793106449867055 1.0210411151887453 1.003048548787553 0.9783354318009228 1.0511346719693453 1.1162315630792319 1.2389509099946978 1.2828924132520982 1.3108427886339018 1.0 17.04810338651143 -7.050251901005402 2.691354165864665 1.2319570770638362 1.0391441654012674 0.3857282417554897 0.09381673934579429 0.2485282417847155 3.56938891130362 0.03815458918101662 0.02960997204676821 8.907341415368504e-08 7.050251901005402 -0.19281291166256875 APS(ph)RQDVYGPQPQVR ddPTM_A459_Selumetinib_30min_R1 1 APSRQDVYGPQPQVR 15 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 APS(1)RQDVYGPQPQVR 90.706 0.008408200000000001 66912000.0 1227.9 1146.4 1640.4 1621.2 1534.0 1415.6 1539.8 1261.3 660.37 1239.1 True False 1256.5076809225168 1012.1789550530987 1417.64269007221 1338.0878536930463 1395.2499708496969 1401.360349261961 1423.6516462999086 1227.8462267201935 1120.599658483497 1398.1505548560904 0.8986926883935238 0.7239413177197364 1.0139413707260774 0.9570413207973685 0.99792541368573 1.0022957430404917 1.0182391598352891 0.8781931405424175 0.8014871178153191 1.0 10.449304005210475 -5.26926971345683 24.964095383108354 0.9593237357116708 0.811316999972128 0.37361766699094767 0.07629821016904215 548.3829023330387 1748318.637448365 0.02060768911706921 0.04420179541500522 5.379356002082006e-06 5.26926971345683 -0.14800673573954282 APS(ph)RQDVYGPQPQVR ddPTM_A459_Selumetinib_30min_R2 4 APSRQDVYGPQPQVR 15 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 APS(1)RQDVYGPQPQVR;APS(1)RQDVYGPQPQVR;APS(1)RQDVYGPQPQVR;APS(1)RQDVYGPQPQVR 113.11 0.0015639 152291200.0 123255.0 136531.0 120575.9 111418.0 101163.0 98356.0 90327.5 117754.0 91731.6 118936.0 True False 116404.98052885816 147002.48868364154 112818.17786711364 96242.6761932296 88453.99953130532 111903.64621312784 94527.90773054576 118096.64464477576 110080.48319505424 115502.00864716017 1.0078178024111808 1.2727266859289885 0.9767637739682503 0.8332554327019136 0.7658221754525316 0.9688458886890466 0.8184092106944488 1.0224639902630765 0.9530612020032673 1.0 16.81755841560281 -5.472710061769688 6.848971090910815 0.9025661414051451 1.1385317603893523 0.4630134348979996 0.09825288241539666 0.19037727870992668 21.203853217202408 0.02547722641211767 0.052651569660005754 3.3673630201345353e-06 5.472710061769688 0.2359656189842072 APS(ph)SDEECFFDLLTK ddPTM_A459_Selumetinib_30min_R2 1 APSSDEECFFDLLTK 15 0 A0A0A0MSK4;A0A0A0MRC4;Q86YR5-4;Q86YR5 A0A0A0MSK4 GPSM1 G-protein-signaling modulator 1 1 APS(0.976)S(0.024)DEECFFDLLTK 158.65 0.00013092 0.0 5549.8 5904.7 6857.4 6969.5 6614.1 3951.6 6204.3 6213.7 4083.0 5965.7 True False 5241.364333609652 6357.571503397032 6416.202349772595 6020.242076941898 5783.177627195779 4495.897030946731 6492.8122435872165 6231.780838266586 4899.714088551886 5793.454740249924 0.9047044584978573 1.0973713938296465 1.1074915810071222 1.0391454403046205 0.9982260821021445 0.7760304054352175 1.1207151060451925 1.075658845657566 0.8457326946064166 1.0 12.500208194235135 -6.338173542074942 4.697170985039272 0.9697977732721161 1.0465426075928597 0.08834815947271912 0.10708617498080855 0.5687896107455043 23.208590577658953 0.03450821891011618 0.039632238010552816 4.590145560823307e-07 6.338173542074942 0.07674483432074353 APS(ph)SSSLNSATSSQSK ddPTM_A459_Selumetinib_30min_R2 2 APSSSSLNSATSSQSK 16 0 A0A2R8Y534;A0A2R8Y4Q0;Q5F1R6;Q5F1R6-3;Q5F1R6-2 A0A2R8Y534 DNAJC21 DnaJ homolog subfamily C member 21 1 APS(0.998)S(0.002)SSLNSATSSQSK;APS(0.963)S(0.035)S(0.001)SLNSATSSQSK 124.04 0.0011167 0.0 10653.1 12020.1 8566.0 12224.2 11860.1 7044.200000000001 9223.0 8286.2 8718.5 9313.8 True False 10061.043349738185 12942.003019286778 8014.872885955618 10559.242872078798 10370.12820736074 8014.474609119076 9651.887775027793 8310.311470145749 10462.443615243601 9044.886393841414 1.1123460164838184 1.4308640767559975 0.8861220071722378 1.167426810276854 1.1465183481377579 0.8860779738014248 1.0671098955537663 0.9187856108180826 1.1567247126915148 1.0 13.142886666992196 -5.26349795783919 24.99995869009067 1.0311505271327428 1.2716050423198595 0.3780682225512235 0.12463762627598239 167.20883664796122 2030657.8702094993 0.03073790049550541 0.0696022371654745 5.451324590314649e-06 5.26349795783919 0.2404545151871167 APS(ph)VANVGSHCDLSLK ddPTM_A459_Selumetinib_30min_R1 2 APSVANVGSHCDLSLK 16 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 APS(1)VANVGSHCDLSLK;APS(0.999)VANVGS(0.001)HCDLSLK 115.74 0.0013071 135634000.0 14889.0 11515.2 5662.2 5579.1 6468.4 7365.4 8814.599999999999 8401.0 4694.4 8697.9 True False 15235.884731049233 10166.99503072876 4893.304340238278 4604.814917677573 5883.334362088774 7291.310763248132 8149.707625324829 8178.178189706138 7966.053934589592 9814.360189720603 1.5524073333896025 1.0359304971685777 0.4985861783800684 0.4691915548912276 0.5994618343283222 0.7429226788400256 0.8303860330967572 0.8332869419518376 0.81167328084546 1.0 13.260678504344979 -4.891591854388126 3.1268585149626236 0.7093510156396293 1.5882300294948974 0.7231771743437779 0.1572910334775344 0.15827030704815673 2.6313565397152714 0.04362869931987079 0.30027905961276113 1.2835362705744274e-05 4.891591854388126 0.8788790138552681 APS(ph)VANVGSHCDLSLK ddPTM_A459_Selumetinib_30min_R2 3 APSVANVGSHCDLSLK 16 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 APS(1)VANVGSHCDLSLK;APS(0.997)VANVGS(0.003)HCDLSLK;APS(1)VANVGSHCDLSLK 121.46 0.0010073 232021000.0 316605.0 183124.0 280382.0 345165.0 353076.0 365770.0 429170.0 398675.0 360771.0 259140.0 True False 299009.3615702335 197169.0219635336 262342.5273768394 298152.93155716395 308719.43634051154 416151.4973705296 449127.2553842217 399835.0782458005 432935.2807839705 251657.95487342094 1.1881577982330396 0.783480188666024 1.0424567246793077 1.1847546472637 1.2267422124438363 1.6536393517933727 1.7846733897608122 1.588803653939371 1.7203321905787898 1.0 17.941104676384676 -6.457052868295064 1.8301829534189173 1.600720796049612 1.0062926717723244 0.503892665559822 0.23054271734820275 0.24868602828401865 1.6654991705399558 0.08181167095187758 0.09339780319542579 3.4909781590623625e-07 6.457052868295064 -0.5944281242772875 APS(ph)VATVGSICDLNLK ddPTM_A459_Selumetinib_30min_R1 2 APSVATVGSICDLNLK 16 0 O75369-8;O75369-2;O75369-9;O75369;E7EN95;O75369-7;O75369-5;O75369-4;A0A0C4DGA1 O75369-8 FLNB Filamin-B 1 APS(1)VATVGSICDLNLK;APS(0.685)VAT(0.315)VGSICDLNLK 245.39 2.7669999999999997e-22 143031000.0 9350.5 9577.0 6227.9 6722.200000000001 6962.0 7752.7 8316.0 8138.6 5145.5 6722.0 True False 9568.348457094224 8455.720387773488 5382.185387405948 5548.293961322106 6332.288329240935 7674.714876888394 7688.717424749991 7922.737890101458 8731.537687549153 7584.8341778247495 1.2615105660541053 1.1148194132569025 0.709598293281278 0.7314983862855257 0.8348618019566209 1.0118500545900426 1.0136961790448837 1.0445499142571388 1.1511837283242052 1.0 12.888901924798871 -6.946623260221193 6.650699786907068 1.050281991324729 0.9172781865306211 0.11343637962736541 0.16002314048033298 0.487109294883466 46.37794868501419 0.06374068761827562 0.05593796403384479 1.13077641005056e-07 6.946623260221193 -0.1330038047941079 APS(ph)VATVGSICDLNLK ddPTM_A459_Selumetinib_30min_R2 2 APSVATVGSICDLNLK 16 0 O75369-8;O75369-2;O75369-9;O75369;E7EN95;O75369-7;O75369-5;O75369-4;A0A0C4DGA1 O75369-8 FLNB Filamin-B 1 APS(0.992)VAT(0.008)VGSICDLNLK;APS(1)VATVGSICDLNLK 236.31 3.0559999999999997e-21 110850000.0 147655.0 109634.0 135037.0 150484.0 130819.0 113988.0 123945.0 127031.0 103113.0 129721.0 True False 139448.92620979727 118042.57527112801 126348.86643716872 129987.81960062047 114384.34768330156 129688.81231996046 129708.6880923581 127400.63917888574 123738.48121794066 125975.61767436503 1.1069517164048321 0.9370271600990028 1.002962865113855 1.0318490355540593 0.9079879884294293 1.0294755025944282 1.0296332773508816 1.0113118834487818 0.9822415123043321 1.0 16.942785004477827 -8.257794111995956 23.756630624167315 0.9911207623864756 1.003684469121127 0.011698453966804134 0.05158805951343753 1171.81092817859 7637149.509476143 0.03693404232112104 0.012605435340291215 5.5233922724758706e-09 8.257794111995956 0.012563706734651459 APS(ph)YSGLSMVSGVK ddPTM_A459_Selumetinib_30min_R1 2 APSYSGLSMVSGVK 14 0 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0;A0A2R8Y5N9;A0A2R8YFW8;A0A2R8YCL5 A0A2R8Y7K2 SPAST Spastin 1 APS(1)YSGLSMVSGVK;APS(0.975)YS(0.025)GLSMVSGVK 151.07 0.00040885 257280000.0 2530.3 2777.6099999999997 3065.9 2847.6000000000004 2682.5 2431.08 2614.91 2411.67 1477.5700000000002 1818.0500000000002 True False 2589.2510668932705 2452.406129924143 2649.5676197832163 2350.3201160722433 2439.86834863384 2406.6255424440287 2417.665233423881 2347.704677391811 2507.3283725569913 2051.4144268066466 1.2621784428628848 1.1954708409366623 1.2915808649682212 1.1457071205894223 1.1893590669691663 1.1731542446985346 1.1785357467663724 1.1444321765087648 1.2222437064850165 1.0 11.00240325922079 -14.52287874527984 0.14994805621735346 0.30703641510293644 1.2578095481373779 0.6845015646041255 0.042109866674189575 76.49497447352425 0.6788919722578127 15.838891836250687 0.20702628164153838 3.000000000003437e-15 14.52287874527984 0.9507731330344414 APS(ph)YSGLSMVSGVK ddPTM_A459_Selumetinib_30min_R2 2 APSYSGLSMVSGVK 14 0 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0;A0A2R8Y5N9;A0A2R8YFW8;A0A2R8YCL5 A0A2R8Y7K2 SPAST Spastin 1 APS(1)YSGLSMVSGVK;APS(0.849)YS(0.151)GLSMVSGVK 176.43 6.9275e-05 103890000.0 198854.0 193643.0 207433.0 271510.0 231734.0 164230.0 182850.0 206183.0 140852.0 166109.0 True False 187802.49075563333 208494.79543961742 194086.98661597373 234529.86961912594 202621.50319175512 186851.19176849394 191352.88731040148 206782.9583945671 169026.33573370325 161313.0015669868 1.164211743203145 1.2924859956377288 1.2031701396082275 1.4538807618785465 1.256076703201227 1.1583145186899406 1.1862211071123139 1.2818740980943093 1.0478159484467433 1.0 17.29950319650316 -8.340062358604257 4.371544297175867 1.0054980561498692 1.2514156594959536 0.5497357653994154 0.08191947656121208 0.17321233879458037 5.829246931521049 0.0805363066965524 0.021429259680045405 4.570225628651253e-09 8.340062358604257 0.24591760334608437 APSALSS(ph)SPLLTAPHK ddPTM_A459_Selumetinib_30min_R2 1 APSALSSSPLLTAPHK 16 0 Q70SY1-2;Q70SY1 Q70SY1-2 CREB3L2 Cyclic AMP-responsive element-binding protein 3-like protein 2;Processed cyclic AMP-responsive element-binding protein 3-like protein 2 1 APSALS(0.133)S(0.529)S(0.338)PLLTAPHK 83.792 0.026512 0.0 21276.0 16865.0 24529.0 25202.0 28416.0 15435.0 23194.0 22924.0 17750.0 21608.0 True False 20093.5650945762 18158.49127047792 22950.83084515589 21769.44412412509 24846.128037736824 17561.031145020435 24272.566958039097 22990.705044727507 21300.495976437905 20984.120895673655 0.9575604903572079 0.8653443887764533 1.0937237237271025 1.0374246427742106 1.1840442666749698 0.8368723775624565 1.1567111664441196 1.0956239319736074 1.015076880386706 1.0 14.3570104040781 -5.263466646931353 24.989859449682278 1.0560395498076605 0.91145243558887 0.267139352295489 0.0932513000183171 205.55885763079604 2533936.3043682664 0.023243257611771873 0.05257593767219219 5.451717623341747e-06 5.263466646931353 -0.14458711421879045 APSAS(ph)PLALHASR ddPTM_A459_Selumetinib_30min_R1 2 APSASPLALHASR 13 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 APS(0.145)AS(0.855)PLALHASR;APS(0.308)AS(0.678)PLALHAS(0.014)R 115.09 0.0040713 12679900.0 2659.9700000000003 3163.4 2842.4700000000003 3260.4 5438.4 2834.4 3989.2000000000003 2949.21 1247.53 1780.31 True False 2721.9421255993707 2793.027657375238 2456.4781865700775 2691.032345287941 4946.497680227503 2805.888509429291 3688.2914322766524 2870.9873704158103 2116.9672940138357 2008.8301301879176 1.354988699489859 1.3903752315353624 1.222840174315926 1.339601743745354 2.462377284118483 1.3967773916089221 1.8360394823088542 1.4291837459383594 1.053830914919522 1.0 10.972139857346054 -8.204083969139742 3.4629941063611063 1.0080450074570573 1.57299637456248 0.28506987712797405 0.33958561111376406 0.32604248482551784 7.411804812444669 0.2968643519070506 0.09245622973124941 6.250518297648844e-09 8.204083969139742 0.5649513671054227 APSAS(ph)PLALHASR ddPTM_A459_Selumetinib_30min_R2 1 APSASPLALHASR 13 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 APS(0.14)AS(0.86)PLALHASR 99.813 0.0075654 6476500.0 5379.2 5073.1 9712.7 14680.0 14093.0 9671.5 5930.5 6766.7 8276.1 13761.0 True False 5080.2455986437435 5462.190457412484 9087.795456388176 12680.558675587501 12322.51134698146 11003.661335864284 6206.280001062809 6786.389976712513 9931.551253554808 13363.684174628157 0.38015307248048613 0.4087338780261521 0.6800366828214902 0.9488819482626194 0.922089386875557 0.8234002833406874 0.46441384875331343 0.507823283462275 0.7431746458368508 1.0 13.70603017237225 -5.299480341354111 3.9398160303516088 0.7515275949383319 0.3864951408129472 0.4405271779169174 0.1667264959702012 0.22371307739587978 7.589913700244448 0.049397916444126326 0.12076031976419023 5.017872922781704e-06 5.299480341354111 -0.36503245412538465 APSDS(ph)SLGTPSDGRPELR ddPTM_A459_Selumetinib_30min_R1 3 APSDSSLGTPSDGRPELR 18 1 Q15642;M0R2H7;M0R0F9;W4VSQ9;Q15642-5;Q15642-4;Q15642-2;Q15642-3 Q15642 TRIP10 Cdc42-interacting protein 4 1 APS(0.016)DS(0.654)S(0.328)LGT(0.002)PSDGRPELR;APS(0.272)DS(0.457)S(0.272)LGTPSDGRPELR;APS(0.018)DS(0.831)S(0.151)LGTPSDGRPELR 227.63 5.2391e-18 71758600.0 6900.5 7155.4 7845.599999999999 8734.4 8034.5 6130.8 7232.3 6796.9 4043.41 5738.4 True False 7061.268223964356 6317.642441544784 6780.210612795982 7209.101004994172 7307.780893606187 6069.129718321021 6686.761788241863 6616.624132557273 6861.371451017998 6474.9795367494135 1.0905468015593565 0.9757007579233807 1.0471400835036155 1.113378191248046 1.1286183766497058 0.9373202932727509 1.032707786996153 1.021875682386939 1.059674615506594 1.0 12.660659918036291 -6.75221086900455 24.99999787930024 1.0130824065089046 1.0667984071774168 0.27672169276482006 0.04876984556815 328.7149869158711 890486.5735641018 0.017258271875617816 0.017027796239469987 1.7692497014608762e-07 6.75221086900455 0.05371600066851223 APSDSS(ph)LGTPSDGRPELR ddPTM_A459_Selumetinib_30min_R1 1 APSDSSLGTPSDGRPELR 18 1 Q15642;M0R2H7;M0R0F9;W4VSQ9;Q15642-5;Q15642-4;Q15642-2;Q15642-3 Q15642 TRIP10 Cdc42-interacting protein 4 1 APSDS(0.02)S(0.592)LGT(0.373)PS(0.015)DGRPELR 222.64 6.1247e-14 5036500.0 1099.4 1125.4 1110.5 1329.6 1384.3 1269.2 1299.3 1184.4 611.85 717.26 True False 1125.013880939992 993.6376448157342 959.7001995398622 1097.4103196831202 1259.090309418016 1256.4330003413968 1201.292754927569 1152.9858645265977 1038.2647622440863 809.3273077040436 1.3900604492532327 1.2277327545447034 1.185799849337108 1.355953653406717 1.5557244855482406 1.5524411302835361 1.4843101715367548 1.4246224655355677 1.2828737549824045 1.0 9.660579464375726 -3.7519535710880523 21.932906060286086 1.365698351485228 45.4702020555511 0.0 0.1676917583425798 0.0 0.0 0.03952240715624063 0.0 0.0001770298204622774 3.7519535710880523 44.10450370406587 APSDSS(ph)LGTPSDGRPELR ddPTM_A459_Selumetinib_30min_R2 1 APSDSSLGTPSDGRPELR 18 1 Q15642;M0R2H7;M0R0F9;W4VSQ9;Q15642-5;Q15642-4;Q15642-2;Q15642-3 Q15642 TRIP10 Cdc42-interacting protein 4 1 APSDS(0.024)S(0.976)LGTPSDGRPELR 227.63 5.2391e-18 2830600.0 9349.1 13307.0 13943.0 11275.0 14679.0 10151.0 8454.1 11130.0 11226.0 10560.0 True False 8829.51444941259 14327.604111251085 13045.922559990562 9739.325549540128 12834.892788075 11549.208108396657 8847.23240148134 11162.386457329312 13471.513680647438 10255.105361824966 0.8609871998273958 1.39711915243564 1.2721393003483439 0.9497050694179263 1.2515612795021487 1.1261910727303728 0.8627149199671328 1.0884711627519437 1.3136397145948084 1.0 13.324054693814949 -7.0114498314018965 24.646934260731438 1.0622753331167374 1.1595626019191678 0.04077369825283861 0.17841824134901457 1507.8455606259624 3245789.4458399285 0.0656580982810438 0.05399032379965004 9.739802905655746e-08 7.0114498314018965 0.09728726880243044 APSDSSLGT(ph)PSDGRPELR ddPTM_A459_Selumetinib_30min_R1 1 APSDSSLGTPSDGRPELR 18 1 Q15642;M0R2H7;M0R0F9;W4VSQ9;Q15642-5;Q15642-4;Q15642-2;Q15642-3 Q15642 TRIP10 Cdc42-interacting protein 4 1 APSDS(0.019)S(0.101)LGT(0.879)PS(0.001)DGRPELR 175.27 4.7275e-08 5261600.0 2161.6 2450.1 2226.0 2791.9 2520.7 1904.0 1939.4 2439.6 1202.9 1895.8 True False 2211.9610742585814 2163.2411529794113 1923.7214265427592 2304.3470754537484 2292.70313006573 1884.84748869368 1793.1094965801014 2374.8938830623833 2041.2334436600681 2139.1443966557813 1.034040094589518 1.0112646702865413 0.8992947972797899 1.0772283904986666 1.0717851182229745 0.881122140067003 0.8382367732553953 1.1102073739272391 0.9542289182774283 1.0 11.062818155340842 -6.750261077685056 24.999675054468433 0.9562393489052405 1.0149237088416607 0.1260252320694384 0.08127507249569457 546.1346853148945 1221399.0792853453 0.028386519830226307 0.02813532779116671 1.777210712253098e-07 6.750261077685056 0.05868435993642018 APSDTGSLS(ph)PPWDQDRR ddPTM_A459_Selumetinib_30min_R2 1 APSDTGSLSPPWDQDRR 17 1 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5;Q96PC5-5;Q96PC5-8 G3V599 MIA2 Melanoma inhibitory activity protein 2 1 APS(0.008)DT(0.05)GS(0.19)LS(0.752)PPWDQDRR 62.002 0.027796 3952700.0 7746.6 5190.3 7504.4 7815.5 10947.0 6196.9 9043.3 8513.9 6217.2 9934.3 True False 7316.074984096822 5588.3793205550855 7021.5750741729335 6751.0154175105035 9571.739992578312 7050.466725142674 9463.831368959 8538.674039447977 7460.813723082246 9647.4709465888 0.7583412300074016 0.5792584762881355 0.7278151043984906 0.6997704843980442 0.9921501754781374 0.7308098427221086 0.9809650033001931 0.8850686451112996 0.7733439949586245 1.0 13.2359350787512 -6.166541316450219 7.224567418085196 0.8839296843496687 0.6840953801755382 0.5237428886595601 0.09424468970030368 0.214723682691611 14.263844928212716 0.026486822627391333 0.034301739066568596 6.81488738455253e-07 6.166541316450219 -0.1998343041741305 APSEEELHGDQTDFGQGS(ph)QSPQKQEEQR ddPTM_A459_Selumetinib_30min_R2 2 APSEEELHGDQTDFGQGSQSPQKQEEQR 28 1 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-2;A0A087WWG1 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 APSEEELHGDQT(0.005)DFGQGS(0.498)QS(0.498)PQKQEEQR;APSEEELHGDQT(0.069)DFGQGS(0.466)QS(0.466)PQKQEEQR 65.278 0.00053645 24878300.0 45396.5 32558.4 36187.3 34209.2 38659.8 26954.8 34204.6 37420.2 35544.8 30519.4 True False 42873.5442665881 35055.52458824357 33859.04851575319 29549.847945838424 33803.01030100292 30667.579028687855 35795.18167512907 37529.0865867524 42654.75320469242 29638.225623075836 1.4465624498521754 1.1827808126593757 1.142411456959525 0.9970181184811346 1.140520715743673 1.0347306015786106 1.207736999183228 1.2662393175633586 1.4391803931569414 1.0 14.855171458724403 -10.70919306476974 13.23594662439183 0.9999964190672505 1.1924406064030286 0.15495733750686314 0.14124197674975544 0.0 0.0 0.14377749788096722 0.03487116531472043 1.9534708510427894e-11 10.70919306476974 0.19244418733577817 APSLT(ph)NDEVEEFR ddPTM_A459_Selumetinib_30min_R1 2 APSLTNDEVEEFR 13 0 Q13206;A0A3B3ISR7;E9PIF2 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 APS(0.113)LT(0.887)NDEVEEFR;APS(0.237)LT(0.763)NDEVEEFR 156.72 0.00085395 45409000.0 1049.03 860.12 1007.98 1377.54 1160.1399999999999 1112.08 1044.1999999999998 1088.73 652.1099999999999 977.44 True False 1073.4703579429495 759.4167505410607 871.1018524378118 1136.9784986283737 1055.205541839353 1100.8934848878512 965.4351533097563 1059.8533437065537 1106.5830417700272 1102.903945071857 0.9733126467990013 0.6885610972146652 0.7898256746022042 1.0308953048076157 0.9567519878357165 0.9981771212325523 0.8753574213091203 0.9609661371167746 1.0033358269454105 1.0 10.10709143279639 -5.751295496747942 24.99014387409551 0.969487670095472 0.8043658811830499 0.47110262195020347 0.07611254629676135 168.33888329087034 414710.2611717694 0.020121223891048767 0.03434625891112246 1.7729827215903558e-06 5.751295496747942 -0.16512178891242213 APSLT(ph)NDEVEEFR ddPTM_A459_Selumetinib_30min_R2 2 APSLTNDEVEEFR 13 0 Q13206;A0A3B3ISR7;E9PIF2 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 APS(0.036)LT(0.964)NDEVEEFR;APS(0.202)LT(0.798)NDEVEEFR 172.42 0.00041206 25434000.0 14918.5 12985.0 12746.8 14166.8 16152.1 9091.5 9921.5 14014.5 11095.9 11712.8 True False 14089.389493487257 13980.907746644276 11926.684765666481 12237.257400906883 14122.928796393895 10343.771600580061 10382.869409079281 14055.27987477462 13315.39004534972 11374.621030490849 1.2386689152736772 1.2291317406678435 1.0485346926016936 1.0758386910740716 1.241617523655155 0.90937285495952 0.9128101394540464 1.2356701675684831 1.1706227407186964 1.0 13.473530859230959 -5.25322731483978 22.829453173409874 1.0770967777746543 1.2339004266017164 0.2487461100534919 0.1108548089162535 280.73136352387854 780411.7274439402 0.0299548004937832 0.0760169144490732 5.581779613543284e-06 5.25322731483978 0.1568036488270621 APSPAPRPVPGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 APSPAPRPVPGSPAR 15 1 Q5TZA2-2;Q5TZA2 Q5TZA2-2 CROCC Rootletin 1 APSPAPRPVPGS(1)PAR 65.895 0.035594 4141600.0 10100.0 10776.0 10924.0 11092.0 10150.0 6509.5 6820.1 9434.7 5928.1 11565.0 True False 9538.68243350345 11602.484549698778 10221.161733151897 9581.250465232735 8874.866257848713 7406.12453764241 7137.2481637717665 9462.153415001338 7113.885644953331 11231.088400521374 0.849310600481129 1.0330685803488255 0.9100775782939619 0.8531007969617576 0.7902053604561353 0.6594307046233027 0.6354903380014744 0.842496566455846 0.6334101728398014 1.0 13.455210125092686 -6.080194762776075 1.9376962644808764 0.7378687371956214 0.9429151171230041 0.3147318754139099 0.11225853632461526 0.3440347251091731 2.565580902135895 0.03533699174000325 0.053085435752267734 8.313908437251721e-07 6.080194762776075 0.20504637992738273 APSPAPS(ph)SVPLGSEKPSNVSQDR ddPTM_A459_Selumetinib_30min_R1 4 APSPAPSSVPLGSEKPSNVSQDR 23 1 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 APS(0.002)PAPS(0.927)S(0.066)VPLGS(0.005)EKPSNVSQDR;APS(0.014)PAPS(0.804)S(0.182)VPLGSEKPSNVSQDR;APS(0.321)PAPS(0.339)S(0.339)VPLGSEKPSNVSQDR;APS(0.074)PAPS(0.463)S(0.463)VPLGSEKPSNVSQDR 151.96 2.8727e-08 427250000.0 7073.5 8185.900000000001 8680.800000000001 9135.1 7826.7 7802.0 7722.000000000001 7852.2 4318.86 6983.1 True False 7238.298787364952 7227.491022478333 7501.995040221195 7539.826272064742 7118.776366916117 7723.518963649215 7139.52332298213 7643.934148459765 7328.789982945975 7879.448906154118 0.9186300810595515 0.9172584413655398 0.9520964130323736 0.9568976665583656 0.9034612003583283 0.9802105522401299 0.9060942469473873 0.9701102500315208 0.9301145384954448 1.0 12.943879014830872 -14.522878745280336 0.1897232661074803 1.2648370040245467 0.9267993386169152 0.36825222751262343 0.02512203887687754 144.35719235828813 1.4072858755742792 14.450998131912007 0.0643921942877366 3.0000000000000132e-15 14.522878745280336 -0.33803766540763147 APSPAPS(ph)SVPLGSEKPSNVSQDR ddPTM_A459_Selumetinib_30min_R2 3 APSPAPSSVPLGSEKPSNVSQDR 23 1 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 APS(0.116)PAPS(0.691)S(0.192)VPLGSEKPSNVSQDR;APS(0.239)PAPS(0.569)S(0.192)VPLGSEKPSNVSQDR;APS(0.286)PAPS(0.544)S(0.17)VPLGSEKPSNVSQDR 115.88 5.957300000000001e-06 422598000.0 96854.0 92551.0 97500.0 93258.0 102508.0 76062.0 81490.0 85715.0 68920.0 83243.0 True False 91471.2424172815 99649.3641016307 91226.95614997369 80556.09952097698 89630.02860685285 86538.85007791032 85279.44646937157 85964.41645911786 82705.9257856959 80839.55829871181 1.1315158610749003 1.232680709775954 1.1284939956361364 0.996493563501579 1.1087397122539835 1.0705012731284225 1.0549222220420087 1.0633954250649056 1.0230873043626443 1.0 16.30277381851105 -2.483078685389015 0.24796918662365322 1.0110370472512313 1.7434587642649124 0.5365451273332758 0.046542560203736816 24.886459854936888 0.511887145635572 0.06405255112020544 6.877676431597354 0.0032879205499916305 2.483078685389015 0.7324217170136811 APSPLGPT(ph)RDPVATFLETCR ddPTM_A459_Selumetinib_30min_R1 1 APSPLGPTRDPVATFLETCR 20 1 I3L2L9;E7EVV8;Q0VG06-3;Q0VG06 I3L2L9 C17orf70;FAAP100 Fanconi anemia-associated protein of 100 kDa 1 APS(0.019)PLGPT(0.97)RDPVAT(0.01)FLETCR 84.895 0.0034539 22460000.0 580.38 918.68 685.13 826.97 703.51 540.81 1100.8 645.86 475.83 699.15 True False 593.9017247771079 811.1205185172548 592.0931091497033 682.5552136494814 639.8776447147789 535.3699424161922 1017.7657697408359 628.7296947510538 807.4487567518245 788.8927127977045 0.7528295231311155 1.028175955182451 0.7505369228851447 0.8652066403667096 0.8111085757726634 0.6786346656918315 1.2901193701377507 0.7969774400898526 1.0235216318430849 1.0 9.623685300863606 -7.230005051692024 24.99897494863215 1.0107363137088783 0.8233866096550453 0.3506208876807241 0.1411040142090443 834.7477454619366 663856.0568050265 0.05184533085862973 0.04015546132665795 5.888368059950266e-08 7.230005051692024 -0.187349704053833 APSPTGPALIS(ph)GASPVHCAADGTVELK ddPTM_A459_Selumetinib_30min_R2 1 APSPTGPALISGASPVHCAADGTVELK 27 0 E7EWD6;Q76L83 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 APS(0.001)PT(0.002)GPALIS(0.742)GAS(0.255)PVHCAADGTVELK 64.209 0.00095147 7137100.0 9919.2 13617.0 17745.0 14755.0 15583.0 10554.0 11216.0 10718.0 6648.7 9596.1 True False 9367.930573703714 14661.380114443984 16603.30601929517 12745.343546205293 13625.324226212459 12007.717700326897 11737.566224082373 10749.187605539586 7978.625780199589 9319.035659337935 1.0052467783312735 1.5732722408624835 1.781654950816525 1.3676676441766913 1.4620959425731461 1.2885150501913605 1.2595258407795664 1.1534656587313945 0.8561643148349564 1.0 13.185964956121882 -7.636578249989611 1.061911381649472 0.9317235067771191 1.4597369200544084 0.4972244417656406 0.19135146965408922 0.4414604104537025 0.9086818568531507 0.16344597776305111 0.07031292559499436 2.3089883942363636e-08 7.636578249989611 0.5280134132772892 APSPTGPALISGAS(ph)PVHCAADGTVELK ddPTM_A459_Selumetinib_30min_R2 1 APSPTGPALISGASPVHCAADGTVELK 27 0 E7EWD6;Q76L83 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 APSPTGPALIS(0.029)GAS(0.971)PVHCAADGTVELK 90.762 1.7692e-05 8742900.0 44871.0 40646.0 46436.0 52599.0 46226.0 41641.0 38571.0 43083.0 32153.0 44575.0 True False 42377.24945284491 43763.41750251083 43448.35831569405 45434.92546166397 40418.67661431666 47376.66977063791 40364.62792698653 43208.3643972254 38584.49842988215 43288.00393024126 0.978960580421679 1.0109825708996816 1.0037043608134761 1.0495962238148582 0.933715416387678 1.0944526305021027 0.9324668328905681 0.9981602401176963 0.8913439042387165 1.0 15.401679656968852 APSQVSISAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 APSQVSISASPR 12 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;Q8IVL1-6;Q8IVL1-7 A0A0A0MTL4 NAV2 Neuron navigator 2 1 APSQVS(0.001)IS(0.052)AS(0.947)PR 86.738 0.029477 8406300.0 525.23 604.05 665.96 731.02 707.61 546.43 528.63 503.87 344.21 439.19 True False 537.4668370803273 533.3275451847736 575.5262898564307 603.3610799449117 643.606800438692 540.9334103187437 488.75501349754546 490.50573079957474 584.0992298962774 495.5643145728728 1.0845551652434262 1.0762024816989677 1.1613553941075785 1.2175232602552284 1.2987351621422076 1.0915503687648989 0.9862595007850873 0.9897922759477586 1.178654743127969 1.0 8.952928492987 -6.993811502120953 24.97905007873113 1.0379801086517118 1.1680240610296349 0.3786140876235121 0.07823504504270525 180.0328212966204 726673.2665058378 0.02954468444371873 0.025987316413744348 1.014351551651487e-07 6.993811502120953 0.1300439523779231 APSQVSISAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 APSQVSISASPR 12 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;Q8IVL1-6;Q8IVL1-7 A0A0A0MTL4 NAV2 Neuron navigator 2 1 APSQVSIS(0.001)AS(0.999)PR 140.03 0.0011086 12224000.0 18571.0 16898.0 12896.0 20907.0 20624.0 12520.0 14162.0 13498.0 12641.0 12050.0 True False 17538.89816560323 18194.022264366195 12066.285400103161 18059.430533413346 18033.028739100675 14244.516354755799 14820.56106147062 13537.2769452858 15169.5532190508 11702.08519034004 1.4987840098858127 1.554767545136758 1.031122676329836 1.5432660282050616 1.541009866684851 1.2172630879934554 1.2664889052170678 1.1568260463922013 1.2963119796438607 1.0 13.51447800557382 -10.61326183007966 0.05656763609116299 1.5110421485424073e-10 2.130994801066339 0.40006819459990484 0.15709128357398147 177.9168293988545 1.8797343168738792 48.648766401004295 24.473223369170032 2.4363415392107367e-11 10.61326183007966 2.130994800915235 APSS(ph)PVAKPGPVK ddPTM_A459_Selumetinib_30min_R1 2 APSSPVAKPGPVK 13 1 Q9GZR2;A0A0C4DG31;Q9GZR2-2 Q9GZR2 REXO4 RNA exonuclease 4 1 APS(0.154)S(0.846)PVAKPGPVK;APS(0.006)S(0.994)PVAKPGPVK 153.0 0.0020101 37733000.0 8449.4 8491.6 8571.0 9215.3 7691.7 6830.7 7101.299999999999 7572.5 4465.5 6530.9 True False 8646.254580329598 7497.3995243622585 7407.105277132969 7606.020847605189 6995.9870930799325 6761.989359779374 6565.643223710573 7371.652701053407 7577.627352784131 7369.204631353112 1.1732954929142736 1.0173960283941264 1.0051431121370418 1.0321359262089855 0.9493544341698311 0.9176009756887098 0.890956833492763 1.0003322027033799 1.0282829330785932 1.0 12.84729320027489 -1.5228787452818116 0.8177018470363826 0.9657341702695763 58.27756133087302 0.6472453540386194 0.043408682273538106 369.1459629609788 1.1876853373619123 0.01672247261159283 39253.80867950572 0.02999999999989818 1.5228787452818116 57.31182716060344 APST(ph)PVPPSPAPAPGLTK ddPTM_A459_Selumetinib_30min_R2 1 APSTPVPPSPAPAPGLTK 18 0 F8W126;Q96EZ8-3;Q96EZ8;Q96EZ8-2;F8W0I9;F8VVA6;F8VP44 F8W126 MCRS1 Microspherule protein 1 1 APS(0.046)T(0.954)PVPPSPAPAPGLTK 139.46 0.00076291 5799100.0 21698.0 19687.0 21426.0 23701.0 28385.0 21035.0 21077.0 21317.0 20935.0 21171.0 True False 20492.112023976042 21196.929596317732 20047.47448686495 20472.882913494504 24819.02253488034 23932.380313281818 22057.12226328319 21379.028940780678 25122.5849727734 20559.73822113602 0.9967107461956662 1.0309921930098633 0.9750841314825475 0.9957754662677453 1.2071662716680727 1.1640411009065583 1.0728308904540338 1.0398492777890724 1.221931169675431 1.0 14.327534274943439 -6.230863839140279 24.35885726194974 1.1197088717247758 1.0001259584020725 0.4282347665247085 0.0667677073641363 489.3304738721539 389838.5576339476 0.01954561803994434 0.025229039669808398 5.876735722234444e-07 6.230863839140279 -0.11958291332270332 APSTS(ph)PSFEGTQETYTVAHEENVR ddPTM_A459_Selumetinib_30min_R2 1 APSTSPSFEGTQETYTVAHEENVR 24 0 Q9BUT9 Q9BUT9 FAM195A Protein FAM195A 1 APS(0.019)T(0.091)S(0.445)PS(0.445)FEGTQETYTVAHEENVR 215.07 7.8737e-33 4468900.0 4869.4 3553.5 4920.0 7492.9 6602.5 4009.9 8263.8 7437.5 6936.7 4158.4 True False 4598.778241752645 3826.0420236966047 4603.452556490967 6472.354094026539 5773.0349229010935 4562.22732675202 8648.083074409044 7459.141893655589 8324.233827591934 4038.336187179255 1.1387804354557352 0.9474302896929104 1.1399379207471187 1.6027279042727312 1.429557782046252 1.1297294517568879 2.141496565309403 1.8470829440442746 2.0613028340778987 1.0 11.979545303153971 -6.163548206539885 0.7669888813908625 1.7638110003165814 1.0011080219660482 0.30456521724054453 0.35218391248372605 0.8312331333750608 1.0272005996289157 0.194532501931739 0.38583545822840076 6.862017060278511e-07 6.163548206539885 -0.7627029783505332 APSTSPS(ph)FEGTQETYTVAHEENVR ddPTM_A459_Selumetinib_30min_R2 1 APSTSPSFEGTQETYTVAHEENVR 24 0 Q9BUT9 Q9BUT9 FAM195A Protein FAM195A 1 APS(0.01)T(0.037)S(0.138)PS(0.814)FEGTQETYTVAHEENVR 146.17 1.3167999999999998e-09 5504900.0 6451.7 5664.1 6946.7 6738.6 9449.9 5546.1 7433.5 7782.2 8293.4 6208.6 True False 6093.140342201413 6098.51825704797 6499.756884995084 5820.791055266617 8262.719078822116 6310.024932516872 7779.172479200815 7804.844913587435 9952.311736957192 6029.341586119934 1.010581380266852 1.0114733375012765 1.0780210064657951 0.9654107288707248 1.3704181394936408 1.0465529017369153 1.2902192334083615 1.2944771501344134 1.6506465249652258 1.0 12.557784750750544 -6.5861092373398735 0.843522709758715 1.3325802463202412 1.004733843191773 0.30200953823799304 0.17645881510723313 0.714088771354393 1.1217448344413277 0.10278057245384441 0.11729388588293571 2.5935269347261826e-07 6.5861092373398735 -0.32784640312846824 APT(ph)PPSTPVPLPEK ddPTM_A459_Selumetinib_30min_R2 1 APTPPSTPVPLPEK 14 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 APT(0.995)PPS(0.004)T(0.001)PVPLPEK 91.207 0.04039 1840700.0 24922.0 21201.0 25820.0 22086.0 27759.0 22598.0 24811.0 29493.0 22262.0 23405.0 True False 23536.93501067061 22827.048528040457 24158.769310690404 19077.848699524904 24271.666251391372 25710.6693757805 25964.760662063803 29578.819747171023 26715.022052251312 22729.23683650695 1.0355356486437928 1.0043033425291432 1.0628939935144408 0.8393528052328926 1.0678610296500155 1.1311716957643239 1.1423507462582319 1.3013556046748784 1.1753593947924608 1.0 14.47226162416845 -6.709433297510065 2.768374490216677 1.1734754161132481 0.9896181818319257 0.41725763042305064 0.08931738085792927 0.23854872921568165 3.7319000031801624 0.03237680733059191 0.03098168279021757 1.952390575090755e-07 6.709433297510065 -0.1838572342813224 APTAALPQGVVMAAS(ph)PGSLHSPQQLAEEATR ddPTM_A459_Selumetinib_30min_R2 3 APTAALPQGVVMAASPGSLHSPQQLAEEATR 31 0 E9PAR2;Q03060-22;Q03060-15;Q03060-16;Q03060-31;Q03060-20;Q03060-21;Q03060-32;Q03060-26;Q03060-29;Q03060-7;Q03060-12;G5E998;C9IYM9;C9K092;J3KR46;Q03060;Q03060-6;Q03060-2;Q03060-23;Q03060-9;Q03060-11;Q03060-24;Q03060-27;Q03060-8;E9PB41;Q03060-10;Q03060-28;Q03060-19;Q03060-14;Q03060-13;Q03060-17;Q03060-30;Q03060-1 E9PAR2 CREM cAMP-responsive element modulator 1 APTAALPQGVVMAAS(0.734)PGS(0.211)LHS(0.055)PQQLAEEATR;APT(0.005)AALPQGVVMAAS(0.967)PGS(0.027)LHSPQQLAEEATR;APTAALPQGVVMAAS(0.971)PGS(0.028)LHS(0.001)PQQLAEEATR 95.867 3.4457e-08 9093000.0 43494.2 33772.8 46753.0 55069.9 63413.5 39529.1 37448.7 40744.3 37300.71 47829.8 True False 41076.9664850778 36363.06516333214 43744.96288081754 47569.28461912371 55446.929206117165 44973.87471555734 39190.13875319128 40862.85916741803 44761.894268917065 46448.829397255264 0.8843487988419597 0.7828628974120259 0.9417882742896961 1.0241223565030178 1.1937207013745241 0.9682456005708276 0.8437271565665567 0.8797392678712519 0.963681859150623 1.0 15.503354617835411 -5.422855809860476 5.127204012928974 0.9796733994618683 0.8354908585084786 0.29268096955175404 0.09074679087225794 0.31161718895092855 12.517818779164555 0.027309791519914695 0.05819301193015352 3.7769756950570257e-06 5.422855809860476 -0.14418254095338967 APTAALPQGVVMAASPGS(ph)LHSPQQLAEEATR ddPTM_A459_Selumetinib_30min_R2 1 APTAALPQGVVMAASPGSLHSPQQLAEEATR 31 0 E9PAR2;Q03060-22;Q03060-15;Q03060-16;Q03060-31;Q03060-20;Q03060-21;Q03060-32;Q03060-26;Q03060-29;Q03060-7;Q03060-12;G5E998;C9IYM9;C9K092;J3KR46;Q03060;Q03060-6;Q03060-2;Q03060-23;Q03060-9;Q03060-11;Q03060-24;Q03060-27;Q03060-8;E9PB41;Q03060-10;Q03060-28;Q03060-19;Q03060-14;Q03060-13;Q03060-17;Q03060-30;Q03060-1 E9PAR2 CREM cAMP-responsive element modulator 1 APTAALPQGVVMAAS(0.324)PGS(0.673)LHS(0.003)PQQLAEEATR 90.435 4.1356e-07 3732700.0 16047.0 14824.0 21323.0 21786.0 26546.0 15675.0 12539.0 20400.0 16633.0 20428.0 True False 15155.171981230695 15960.953133327283 19951.101394727022 18818.70921705377 23211.054155748956 17834.088966517345 13122.088345557133 20459.3606225982 19960.06476485025 19838.190561681844 0.7639392279305672 0.8045569016841898 1.005691589295612 0.9486101647497409 1.1700187113124074 0.8989776013627225 0.6614559077229001 1.0313118305313675 1.0061434132709568 1.0 14.275992823281548 -5.16811337617725 5.056306453300104 0.9596881101643324 0.7753796580350044 0.26144906345425023 0.12184811027538985 0.3278961522601777 13.406849981236634 0.03332741815172695 0.09396995478569735 6.790263440167998e-06 5.16811337617725 -0.184308452129328 APTS(ph)VTPVAPGK ddPTM_A459_Selumetinib_30min_R2 2 APTSVTPVAPGK 12 0 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 APT(0.052)S(0.897)VT(0.051)PVAPGK;APT(0.097)S(0.545)VT(0.358)PVAPGK 113.95 0.0059848 3620900.0 63571.0 61143.0 71048.0 83273.0 78958.0 58309.0 63704.0 72806.0 63677.0 57722.0 True False 60037.978314876076 65832.47149426809 66476.84903121351 71931.07374606257 69038.59014652403 66340.53547359873 66666.36222708129 73017.85340631781 76414.17928403601 56055.41588023303 1.0710468805218059 1.174417680441878 1.18591304671161 1.2832136309495799 1.2316132003021905 1.1834812824391616 1.1892938653692164 1.3026012252290915 1.3631899448806364 1.0 15.774566147514802 -4.659586003802807 1.3427118815108685 1.230888814724198 0.9696570206530752 0.18377801673571814 0.09165810072182133 2.6637761273762752 3.4960249506256105 0.02597121913659263 1.028533085309241 2.189848127149604e-05 4.659586003802807 -0.26123179407112285 APTSVT(ph)PVAPGK ddPTM_A459_Selumetinib_30min_R2 1 APTSVTPVAPGK 12 0 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 APT(0.024)S(0.409)VT(0.568)PVAPGK 115.37 0.01233 2791000.0 14950.0 14596.0 15390.0 19143.0 17896.0 11299.0 15754.0 15545.0 13030.0 15680.0 True False 14119.138849591749 15715.46626646284 14399.82415536505 16535.690376483075 15647.74448773009 12855.33468789025 16486.592215958775 15590.233376386717 15636.364088618926 15227.277658467376 0.9272267286556354 1.0320601370084033 0.9456597875430341 1.0859255835062636 1.027612738054258 0.8442306613317603 1.0827012277398866 1.0238358901742042 1.0268653688024183 1.0 13.894370418571704 APVAS(ph)PAALGSTATASPAAPAR ddPTM_A459_Selumetinib_30min_R1 1 APVASPAALGSTATASPAAPAR 22 0 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 APVAS(0.751)PAALGS(0.071)T(0.071)AT(0.053)AS(0.053)PAAPAR 74.78 0.001912 5930800.0 1169.3 1286.5 1557.7 1620.3 1329.4 1355.0 1286.0 938.02 882.72 1264.8 True False 1196.5424149382686 1135.8759819223762 1346.1728958336264 1337.3450217979553 1209.1560047246323 1341.3699302415641 1188.99598463546 913.1406624816265 1497.91136868203 1427.1494001952901 0.8384142646695115 0.7959054474373487 0.9432599667907348 0.9370742976278125 0.8472525753499754 0.9398945408644758 0.8331264999114729 0.6398353685722552 1.0495827335785985 1.0 10.478920654961877 APVASPAALGS(ph)TATASPAAPAR ddPTM_A459_Selumetinib_30min_R1 1 APVASPAALGSTATASPAAPAR 22 0 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 APVAS(0.02)PAALGS(0.401)T(0.401)AT(0.062)AS(0.115)PAAPAR 139.38 1.0354e-05 7236700.0 848.47 999.41 1423.3 1156.1 1077.4 981.1 817.8 940.21 485.76 867.25 True False 868.2377001647754 882.398612586896 1230.0236776272723 954.2088376847596 979.9493602304201 971.2310247675266 756.1126875854425 915.2725765675038 824.2992414933195 978.5699852303645 0.8872515131969679 0.9017225399358341 1.2569603566348024 0.9751053599504484 1.001409582371087 0.9925003213121132 0.7726710393712377 0.9353164212900318 0.8423508322700821 1.0 9.93453122277725 -7.069579592262901 11.558759508507315 0.8821411785934185 1.0097604050755133 0.20909118136574645 0.10924494826832948 1.4792895901805843 243.06009635622476 0.0422982817274127 0.03277393417801248 8.519623596688523e-08 7.069579592262901 0.1276192264820949 APVASPAALGS(ph)TATASPAAPAR ddPTM_A459_Selumetinib_30min_R2 1 APVASPAALGSTATASPAAPAR 22 0 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 APVASPAALGS(0.348)T(0.348)AT(0.291)AS(0.012)PAAPAR 128.44 2.707e-05 2026100.0 5726.6 5912.6 4628.5 6696.7 7514.0 4357.6 7428.4 5164.2 5495.9 5667.9 True False 5408.3384973961265 6366.077407994528 4330.707349129769 5784.597907548148 6570.024143987703 4957.819845645678 7773.835319095356 5179.226967020666 6595.233568276343 5504.2530000272445 0.9825744742055564 1.156574272287814 0.7867929306862045 1.0509324167184022 1.1936268452695002 0.9007252838161941 1.4123324852721846 0.9409500193750233 1.1982068353768802 1.0 12.426331068927382 -5.997283177355428 24.998133565121627 1.1107314406672115 0.9810103980990807 0.11898382366076332 0.1610037566881091 182.1286627619692 1675760.2896329549 0.04299482595792725 0.0633657159485567 1.0062753231745188e-06 5.997283177355428 -0.12972104256813077 APVASPAALGSTATAS(ph)PAAPAR ddPTM_A459_Selumetinib_30min_R2 3 APVASPAALGSTATASPAAPAR 22 0 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 APVASPAALGS(0.105)T(0.253)AT(0.036)AS(0.606)PAAPAR;APVASPAALGS(0.263)T(0.203)AT(0.079)AS(0.454)PAAPAR;APVASPAALGS(0.022)T(0.347)AT(0.009)AS(0.622)PAAPAR 233.3 7.9567e-31 12125200.0 32253.699999999997 31062.0 33145.6 39087.7 40424.2 29392.2 26856.3 29023.5 27397.800000000003 33591.2 True False 30461.168475791113 33444.355519927936 31013.048182200608 33763.887829956504 35345.75059906675 33440.70875417362 28105.17116474886 29107.95357990093 32878.12555849299 32621.33477558094 0.9337805667778241 1.025229523868627 0.950698320456702 1.0350247180943324 1.0835163809889594 1.0251177330489256 0.8615579760331357 0.89229805524972 1.00787186620899 1.0 14.993528193932605 -7.230779674459602 24.759670566873115 0.9314567907116753 1.0115714029018101 0.24909495218221345 0.0572798590727332 762.9571899758996 616137.375716094 0.02240751302807542 0.017354428772064043 5.877874722466651e-08 7.230779674459602 0.08011461219013483 APVDEDRLS(ph)PLVAADSLLEHVR ddPTM_A459_Selumetinib_30min_R1 3 APVDEDRLSPLVAADSLLEHVR 22 1 Q01094 Q01094 E2F1 Transcription factor E2F1 1 APVDEDRLS(1)PLVAADSLLEHVR;APVDEDRLS(1)PLVAADSLLEHVR;APVDEDRLS(1)PLVAADSLLEHVR 140.8 3.3734e-06 23006300.0 6467.2 6771.4 7692.1 8052.9 7766.7 6970.2 6794.400000000001 6560.5 3083.9300000000003 4841.5 True False 6617.873177019389 5978.6013400615475 6647.555069680842 6646.612186654788 7064.203356322252 6900.086116435234 6281.892937797181 6386.49422849269 5233.203968664552 5462.953685203589 1.2114093507590773 1.0943899005138173 1.2168426555922938 1.2166700597622013 1.2931106070797649 1.2630687562159126 1.1499077787922107 1.1690551662172262 0.9579440482606847 1.0 12.415465476614278 -8.173654725268921 3.2700922671303188 0.9755893383419342 1.2066819410388168 0.738128801107232 0.05324637424726872 0.13744315170303428 2.652901238696512 0.04836024421743141 0.015284459393210194 6.704173958199122e-09 8.173654725268921 0.2310926026968826 APVDEDRLS(ph)PLVAADSLLEHVR ddPTM_A459_Selumetinib_30min_R2 1 APVDEDRLSPLVAADSLLEHVR 22 1 Q01094 Q01094 E2F1 Transcription factor E2F1 1 APVDEDRLS(1)PLVAADSLLEHVR 77.391 0.00067307 779630.0 3770.2 4263.4 3135.0 2523.8 3928.7 3125.3 3464.9 2155.4 2674.4 2517.2 True False 3560.6673773064063 4590.389071008331 2933.2975131299163 2180.0540862021617 3435.1415829763746 3555.7817063513035 3626.0247155690995 2161.67185715432 3209.3547289794687 2444.5218955289592 1.456590502960469 1.8778269400671646 1.1999473265078664 0.8918120513420189 1.405240668639239 1.4545918827132795 1.4833267487606119 0.8842922868099594 1.3128762458006173 1.0 11.255336612253823 -1.5228787454081898 0.3594070131666743 1.16658444551242 7.268772126583614 0.2166264170380312 0.2605338882205977 101.58463075269016 1.4187025272355294 0.2247667157608155 423.8306589248978 0.029999999991168282 1.5228787454081898 6.102187681071194 APVHFVEPLS(ph)PTGVAGHR ddPTM_A459_Selumetinib_30min_R1 4 APVHFVEPLSPTGVAGHR 18 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 APVHFVEPLS(0.625)PT(0.375)GVAGHR;APVHFVEPLS(0.926)PT(0.074)GVAGHR;APVHFVEPLS(0.673)PT(0.327)GVAGHR;APVHFVEPLS(0.999)PT(0.001)GVAGHR 121.77 0.00048171 120235500.0 11867.100000000002 14218.9 13615.400000000001 13797.499999999998 11300.6 13039.9 14098.099999999999 14021.0 8445.6 12291.3 True False 12143.580340643057 12554.144577812729 11766.503464038753 11388.025636152115 10278.462725282976 12908.730445281892 13034.668966554575 13649.117533373366 14331.566357781574 13869.008082400676 0.8755911214770196 0.9051941208213393 0.8484026683184406 0.8211132020755797 0.7411101546855404 0.9307609000287954 0.939841471654714 0.9841451856022534 1.0333519363917503 1.0 13.75957698871245 -7.296040241997129 1.8400189379647214 1.0040901772769033 0.8434400484567599 0.703065280334775 0.04608295168657065 0.2183255935037693 1.4408479378405488 0.026926455705600937 0.016349185792047617 5.057777941463914e-08 7.296040241997129 -0.1606501288201434 APVHFVEPLS(ph)PTGVAGHR ddPTM_A459_Selumetinib_30min_R2 6 APVHFVEPLSPTGVAGHR 18 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 APVHFVEPLS(0.989)PT(0.011)GVAGHR;APVHFVEPLS(0.991)PT(0.009)GVAGHR;APVHFVEPLS(0.894)PT(0.106)GVAGHR;APVHFVEPLS(0.742)PT(0.258)GVAGHR;APVHFVEPLS(0.983)PT(0.017)GVAGHR;APVHFVEPLS(0.898)PT(0.102)GVAGHR 157.0 1.4555e-05 113129800.0 100698.0 80822.59999999999 105450.9 106898.6 117299.90000000001 90032.20000000001 93250.59999999999 101266.79999999999 90412.59999999999 117266.8 True False 95101.60828603279 87021.4335343806 98666.30390025907 92338.82626962951 102563.637887589 102433.31831906109 97586.9376725585 101561.46962237864 108497.64633911519 113881.00278826276 0.835096337032207 0.7641435481225806 0.8663982708661939 0.8108360833572366 0.9006211341349358 0.8994767855136806 0.8569202525727705 0.8918209985489007 0.9527282310715444 1.0 16.797167576451933 -6.602137838428426 0.11758856639745006 1.0977440988218774 0.6326607635720016 0.7439543287095842 0.03260754645347642 9.079428220813348 0.4074791197867181 0.5171602869115381 1.0282038668137874 2.4995519162279603e-07 6.602137838428426 -0.4650833352498758 APVPEPGLDLSLS(ph)PRPDSPQPR ddPTM_A459_Selumetinib_30min_R1 1 APVPEPGLDLSLSPRPDSPQPR 22 1 Q8TAP8 Q8TAP8 PPP1R35 Protein phosphatase 1 regulatory subunit 35 1 APVPEPGLDLS(0.333)LS(0.634)PRPDS(0.033)PQPR 89.62200000000001 0.00024317 7964400.0 933.6 1264.9 1248.1 1068.7 1334.5 1080.9 1100.0 1205.9 614.45 874.41 True False 955.3510635306309 1116.8049199639436 1078.6148753225586 882.0716069835671 1213.7947106251117 1070.0271273786757 1017.0261143849191 1173.9156146847545 1042.6767723476 986.6490409746712 0.9682785102460321 1.1319170987696867 1.093210280990126 0.8940074640038203 1.2302193183363888 1.0845063269119875 1.0307881243975463 1.189800593659008 1.056785877293897 1.0 9.946393187438167 -4.745122213299158 24.239122007290607 1.0830074121007576 0.9682780280703139 0.11779806541209203 0.0903328693682755 1394.6756636582138 2071621.2207942333 0.021760809754624806 0.541823394588934 1.7983647723424606e-05 4.745122213299158 -0.11472938403044364 APVPEPGLDLSLS(ph)PRPDSPQPR ddPTM_A459_Selumetinib_30min_R2 2 APVPEPGLDLSLSPRPDSPQPR 22 1 Q8TAP8 Q8TAP8 PPP1R35 Protein phosphatase 1 regulatory subunit 35 1 APVPEPGLDLS(0.008)LS(0.97)PRPDS(0.022)PQPR;APVPEPGLDLS(0.021)LS(0.958)PRPDS(0.021)PQPR 102.5 5.5547e-05 33430000.0 68867.0 70085.0 73144.0 58247.0 66454.0 41586.0 65603.0 57140.0 56490.0 60446.0 True False 65039.64783644383 75460.29414120616 68437.99467316584 50313.65811832053 58105.45441370222 47314.09401987818 68653.6694898783 57306.267939963785 67789.57846247763 58700.76692243105 1.1079863389585551 1.2855078067535584 1.165879055099942 0.8571209671724818 0.9898585224701494 0.8060217353275885 1.1695531947751094 0.976243939294524 1.1548329266644302 1.0 15.841091731742702 -5.611840902669685 7.701330906038699 0.9921677044178734 1.2037831888416213 0.38265917237929115 0.11271725986932694 0.22279124816724163 16.56405044010928 0.030270844611610684 0.05262747525163337 2.4443258311462744e-06 5.611840902669685 0.2116154844237479 APVPEPGLDLSLSPRPDS(ph)PQPR ddPTM_A459_Selumetinib_30min_R1 2 APVPEPGLDLSLSPRPDSPQPR 22 1 Q8TAP8 Q8TAP8 PPP1R35 Protein phosphatase 1 regulatory subunit 35 1 APVPEPGLDLS(0.001)LS(0.004)PRPDS(0.995)PQPR;APVPEPGLDLS(0.021)LS(0.019)PRPDS(0.961)PQPR 96.723 0.00010705 98392300.0 2032.0300000000002 2072.4300000000003 2628.2700000000004 2543.67 2737.0699999999997 1754.57 2342.05 2268.37 1146.58 1719.4699999999998 True False 2079.372345357915 1829.7889321534326 2271.3653700537006 2099.4657850995513 2489.502501768957 1736.9206188220958 2165.387282904727 2208.2054588958113 1945.6625171101166 1940.1807235561314 1.0717415754686301 0.9431023151284778 1.1706978337000202 1.0820980538614302 1.2831291804641687 0.8952365095342856 1.1160750421928827 1.1381442110446396 1.002825403575775 1.0 10.92197532719545 -10.219745286408628 15.072375291683992 0.9999997880674547 1.0805186329657892 0.04589349593869829 0.10634696354937656 0.0 0.0 0.09981301799839212 0.02420821270700279 6.029130907570206e-11 10.219745286408628 0.0805188448983345 APVPEPGLDLSLSPRPDS(ph)PQPR ddPTM_A459_Selumetinib_30min_R2 4 APVPEPGLDLSLSPRPDSPQPR 22 1 Q8TAP8 Q8TAP8 PPP1R35 Protein phosphatase 1 regulatory subunit 35 1 APVPEPGLDLS(0.001)LS(0.008)PRPDS(0.991)PQPR;APVPEPGLDLS(0.032)LS(0.132)PRPDS(0.836)PQPR;APVPEPGLDLSLSPRPDS(1)PQPR;APVPEPGLDLSLS(0.004)PRPDS(0.996)PQPR 104.66 3.7429e-05 232401000.0 245660.0 214473.0 240180.0 264509.0 269707.0 227009.1 210810.0 217281.6 176577.19999999998 247052.0 True False 232007.20065489682 230922.38946061177 224727.08028821158 228482.41789652364 235823.99544882769 258277.54294156545 220613.08271209037 217913.85348309454 211897.57397919332 239918.96684181652 0.9670231733194479 0.9625016000209088 0.9366790931388878 0.952331618063222 0.982931856339275 1.0765199031215116 0.919531646939548 0.9082810598578878 0.8832047618765453 1.0 17.87218768912107 APVPGT(ph)PDSLSSGSSR ddPTM_A459_Selumetinib_30min_R1 2 APVPGTPDSLSSGSSR 16 0 A0A087WYB4;Q9UJZ1;Q9UJZ1-2 A0A087WYB4 STOML2 Stomatin-like protein 2, mitochondrial 1 APVPGT(0.985)PDS(0.013)LS(0.002)SGSSR;APVPGT(0.993)PDS(0.006)LSSGSSR 188.0 2.0827e-06 54546000.0 6857.5 8435.2 4771.0 4837.5 6000.5 5898.1 7510.9 6565.700000000001 3925.85 6453.6 True False 7017.26640762779 7447.60286258191 4123.124405227086 3992.7214361214633 5457.755834474321 5838.770469046324 6944.346765939716 6391.556307600707 6661.880717260685 7281.982423387356 0.9636478090211554 1.0227438669259397 0.5662090575754417 0.5483014382591946 0.7494876418467843 0.8018105688217668 0.9536341015650814 0.8777220179869029 0.9148443830164837 1.0 12.830115543197536 -7.135783266146004 3.9547892747808575 0.9261620462599242 0.7615012266488067 0.23525491691527356 0.1420678622669249 0.4240194782183645 11.448512818447274 0.06401893457008993 0.048796658727959866 7.315040481439977e-08 7.135783266146004 -0.16466081961111745 APVPGT(ph)PDSLSSGSSR ddPTM_A459_Selumetinib_30min_R2 2 APVPGTPDSLSSGSSR 16 0 A0A087WYB4;Q9UJZ1;Q9UJZ1-2 A0A087WYB4 STOML2 Stomatin-like protein 2, mitochondrial 1 APVPGT(0.999)PDS(0.001)LSSGSSR;APVPGT(0.995)PDS(0.005)LSSGSSR 182.7 2.1186e-06 51736000.0 91476.0 83440.0 80702.0 82331.0 89075.0 66198.0 103574.0 80533.0 79504.0 71105.0 True False 86392.13012744185 89839.57969811327 75509.72118169385 71117.375771103 77884.60215939644 75316.17361438707 108390.3962279874 80767.3376970442 95407.02152736453 69052.01389702321 1.2511167343544511 1.301042136614443 1.0935194633758398 1.0299102337139632 1.1279121022530234 1.0907165390817646 1.5696920351900128 1.1696594080151228 1.3816689209042383 1.0 16.075395870743556 APVPSTCSSTFPEELS(ph)PPSHQAK ddPTM_A459_Selumetinib_30min_R1 4 APVPSTCSSTFPEELSPPSHQAK 23 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;Q14980-4;Q14980-3;F5H6Y5;F5H4J1;F5H763;F5H0Z7 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 APVPSTCSSTFPEELS(0.977)PPS(0.023)HQAK;APVPSTCSSTFPEELS(0.997)PPS(0.003)HQAK;APVPSTCSSTFPEELS(0.99)PPS(0.01)HQAK;APVPSTCSSTFPEELS(0.999)PPS(0.001)HQAK 162.27 4.5148e-10 817712000.0 18085.5 22141.9 22679.3 25366.699999999997 21934.4 19120.1 21654.5 19270.5 10109.4 17594.7 True False 18506.856961742964 19549.516054509968 19599.57562847762 20936.882036932762 19950.43739283286 18927.76915366179 20021.083630862027 18759.383740594225 17154.913438637526 19853.15113189127 0.9321873811767002 0.9847059504375829 0.98722744305279 1.054587349778476 1.0049002931723676 0.9533886599622472 1.0084587327147778 0.944907114037929 0.8640902053619384 1.0 14.27708039253727 -7.917089086330714 5.441014510878612 0.9234366219941293 0.9905297222745307 0.23558128573237702 0.04345132850523254 0.24505710738228922 11.937729583136987 0.024400052739568735 0.011352102576589963 1.2103498304068907e-08 7.917089086330714 0.06709310028040139 APVPSTCSSTFPEELS(ph)PPSHQAK ddPTM_A459_Selumetinib_30min_R2 4 APVPSTCSSTFPEELSPPSHQAK 23 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;Q14980-4;Q14980-3;F5H6Y5;F5H4J1;F5H763;F5H0Z7 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 APVPSTCSSTFPEELS(0.983)PPS(0.017)HQAK;APVPSTCSSTFPEELS(0.988)PPS(0.012)HQAK;APVPSTCSSTFPEELS(0.99)PPS(0.009)HQAK;APVPSTCSSTFPEELS(0.998)PPS(0.002)HQAK 130.69 5.1285e-06 861490000.0 119277.0 119232.0 113388.0 143696.0 136799.0 100448.0 107837.0 121499.0 96048.0 113517.0 True False 112648.0618436626 128376.71100869364 106092.7395275198 124124.35691057374 119613.08662142328 114283.80022384277 112851.63417496174 121852.54197475771 115260.28380534683 110239.4692574135 1.0218487316972193 1.164525844268435 0.9623843460257332 1.1259520546197341 1.0850295944560657 1.0366867782807045 1.0236953691372437 1.1053440550428197 1.0455446182910182 1.0 16.75028132182296 -6.761483537794117 24.99999999934067 1.0476782423153765 1.074004664847811 0.0589676526036097 0.057002285992390905 4.368611899922749 2471067.8456520005 0.01860807847470293 0.01747883360513255 1.7318746773064088e-07 6.761483537794117 0.026326422532434446 APVQPQQS(ph)PAAAPGGTDEKPSGK ddPTM_A459_Selumetinib_30min_R1 4 APVQPQQSPAAAPGGTDEKPSGK 23 1 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 APVQPQQS(1)PAAAPGGTDEKPSGK;APVQPQQS(1)PAAAPGGTDEKPSGK;APVQPQQS(1)PAAAPGGTDEKPSGK;APVQPQQS(1)PAAAPGGTDEKPSGK 148.69 5.6929e-08 108035000.0 17191.92 17089.7 16791.8 18011.6 14313.58 14642.95 16224.369999999999 16136.8 8370.230000000001 13489.8 True False 17592.458286346962 15088.829979214008 14511.565790755023 14866.212179606278 13018.919216267801 14495.655217734844 15000.552708584783 15708.799644286397 14203.668972588579 15221.347231779268 1.1557753737867085 0.9912939866263225 0.9533693417398457 0.9766686189622207 0.8553066307486096 0.9523240615305512 0.9854944165038487 1.03202426205017 0.9331413807402035 1.0 13.893808436064296 -4.751710864792291 3.110371817793788 0.9597898400363282 1.1940366314437016 0.6335092192335613 0.04418328864855688 0.273667959336566 3.7068434611631127 0.011856074037707264 0.16537480568376875 1.771287815632747e-05 4.751710864792291 0.23424679140737348 APVQPQQS(ph)PAAAPGGTDEKPSGK ddPTM_A459_Selumetinib_30min_R2 4 APVQPQQSPAAAPGGTDEKPSGK 23 1 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 APVQPQQS(1)PAAAPGGTDEKPSGK;APVQPQQS(1)PAAAPGGTDEKPSGK;APVQPQQS(1)PAAAPGGTDEKPSGK;APVQPQQS(0.874)PAAAPGGT(0.063)DEKPS(0.063)GK 104.49 1.243e-05 145788000.0 220587.0 181450.0 213412.0 219860.0 210064.0 167868.0 193826.0 191772.0 158446.0 196561.0 True False 208327.65761972527 195366.63154629234 199681.30426541695 189914.68872034515 183673.8823240129 190990.2932460183 202839.2930589328 192330.02477043628 190139.62735113676 190885.7732031893 1.0913734120874994 1.0234740298761467 1.0460774572909906 0.9949127456355247 0.9622188141203185 1.0005475528169285 1.062621324026173 1.007566051377279 0.9960911395357982 1.0 17.54235005651835 -3.7401070695668874 0.9884192008984035 1.0066253234591707 1.5849942133104438 0.48709569592232305 0.0258742450471017 12.102486639704143 1.9716516017838555 0.009002597857340278 12.035404660849851 0.00018192522907005556 3.7401070695668874 0.5783688898512731 APVS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 APVSPLK 7 0 Q9UBS0 Q9UBS0 RPS6KB2 Ribosomal protein S6 kinase beta-2 1 APVS(1)PLK 92.051 0.02753 31950000.0 4064.7 4924.6 4317.1 4461.6 3782.8 3990.6 4440.5 3963.2 2569.3 3626.7 True False 4159.399601470606 4348.025542615571 3730.8615321328566 3682.4653146045525 3440.6464079075818 3950.4581871748965 4105.54950993294 3858.0830617120982 4359.914445752608 4092.2222720495415 1.0164158554827032 1.0625096227820277 0.9116957203461723 0.8998693301085605 0.8407770104296838 0.9653576772105187 1.0032567238525691 0.9427843370247391 1.0654148665216554 1.0 11.998668792911191 -10.347420412047914 9.510567359087455 1.000013247202363 0.9632498192069043 0.01637369801400146 0.06842160837810933 0.0 0.0 0.07119384995778932 0.017267044898255347 4.493446631441523e-11 10.347420412047914 -0.03676342799545873 APVSGSRS(ph)PDREASGSGGR ddPTM_A459_Selumetinib_30min_R1 3 APVSGSRSPDREASGSGGR 19 2 Q8N5F7 Q8N5F7 NKAP NF-kappa-B-activating protein 1 APVS(0.156)GS(0.156)RS(0.667)PDREAS(0.02)GS(0.001)GGR;APVS(0.006)GS(0.012)RS(0.981)PDREAS(0.001)GSGGR;APVS(0.008)GS(0.009)RS(0.951)PDREAS(0.019)GS(0.013)GGR 82.36200000000002 0.005855600000000001 51781500.0 1034.98 892.94 2065.63 2323.03 1464.15 1125.11 863.51 1040.82 788.8399999999999 663.4300000000001 True False 1059.0930202794902 788.3941696834561 1785.1287916934032 1917.3564191737976 1331.7178910166774 1113.7924149181451 798.3747454841108 1013.214072540167 1338.6038654059414 748.5877028554404 1.4147881620812726 1.0531754217657816 2.3846621910621058 2.5612983112869245 1.7789737741308385 1.4878582838986727 1.066507962178327 1.3535008238518025 1.7881723948976476 1.0 9.548027538873955 -6.818903459697959 3.7077352937613712 1.3280095834066301 1.869441976156309 0.24222318209986982 0.44873334463592385 0.3816526628661883 10.631309703646503 0.1807676557225629 0.1627917903141038 1.517387633499013e-07 6.818903459697959 0.5414323927496789 APVSGSRS(ph)PDREASGSGGR ddPTM_A459_Selumetinib_30min_R2 1 APVSGSRSPDREASGSGGR 19 2 Q8N5F7 Q8N5F7 NKAP NF-kappa-B-activating protein 1 APVS(0.002)GS(0.005)RS(0.991)PDREASGS(0.001)GGR 71.946 0.015326 6970300.0 2456.2 3868.5 2022.8 3723.5 4283.2 2105.2 466.48 615.36 786.35 2450.6 True False 2319.6942369476415 4165.201510811966 1892.6552502581167 3216.3528766042296 3745.1061237061654 2395.172190897117 488.1722443125841 617.1505957216679 943.641972454758 2379.8448105765397 0.9747250016633118 1.7501987912408905 0.7952851555054143 1.3514968969027177 1.573676614148163 1.0064404957215947 0.20512776385377826 0.2593238823720431 0.39651407867479893 1.0 11.216651783274541 -7.0908761217186695 4.435369444978802 0.4098207279468062 1.2918512415213375 0.5850083072039982 0.32565071023130643 0.14726996423820926 5.030959364339063 0.1222481541037773 0.09474730491375295 8.111924096100967e-08 7.0908761217186695 0.8820305135745312 APVSSTESVIQSNT(ph)PTPPPSQPLNETAEEESR ddPTM_A459_Selumetinib_30min_R1 1 APVSSTESVIQSNTPTPPPSQPLNETAEEESR 32 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 APVSSTESVIQS(0.075)NT(0.909)PT(0.016)PPPSQPLNETAEEESR 118.01 1.959e-16 14046000.0 400.9 528.69 605.65 504.09 625.18 351.74 691.76 422.38 233.6 327.5 True False 410.240189984394 466.7907290186874 523.4060565973142 416.0601444412335 568.632579384494 348.2018149543672 639.579986260829 411.17711031639993 396.40213853104285 369.53781512014336 1.1101440047509552 1.2631744571713868 1.4163802327703472 1.1258932845775604 1.5387669573129379 0.9422630126260841 1.7307565290791418 1.1126793889353892 1.0726970889357166 1.0 8.52957819391568 -7.979132432135152 24.99984121325759 1.055127957635457 1.3040017547965015 0.21723695066301907 0.21331579086569455 328.868445762273 393992.01702509506 0.10828215407571078 0.052009364793839996 1.0492224339006517e-08 7.979132432135152 0.2488737971610444 APVSSTESVIQSNT(ph)PTPPPSQPLNETAEEESR ddPTM_A459_Selumetinib_30min_R2 2 APVSSTESVIQSNTPTPPPSQPLNETAEEESR 32 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 APVSSTESVIQS(0.058)NT(0.833)PT(0.109)PPPSQPLNETAEEESR;APVSSTESVIQS(0.069)NT(0.737)PT(0.194)PPPSQPLNETAEEESR 113.17 2.4902e-12 20255200.0 11469.5 11204.0 15581.699999999999 16870.3 20128.0 11057.5 10691.5 12632.0 13044.0 13731.4 True False 10832.071106046327 12063.31077346187 14579.190386072223 14572.536037109254 17599.340693396916 12580.570255008974 11188.675934805333 12668.757028659827 15653.164479811609 13334.938803538193 0.812307522789098 0.9046393801418182 1.0933076334931429 1.0928086174075795 1.3197916355437072 0.9434291705688923 0.8390496649175933 0.9500423822941275 1.173845992878371 1.0 13.702923583663294 -5.065522719965457 3.611870491143139 1.0489191159280156 0.8241977232700887 0.2819150651663962 0.12684466135346079 0.3264604113430428 8.126901177652845 0.03605149606377985 0.13023334057415833 8.599580773029847e-06 5.065522719965457 -0.2247213926579269 APVSSTESVIQSNTPT(ph)PPPSQPLNETAEEESR ddPTM_A459_Selumetinib_30min_R1 3 APVSSTESVIQSNTPTPPPSQPLNETAEEESR 32 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 APVSSTESVIQSNT(0.001)PT(0.999)PPPSQPLNETAEEESR;APVSSTESVIQSNT(0.002)PT(0.992)PPPS(0.006)QPLNETAEEESR;APVSSTESVIQSNT(0.002)PT(0.998)PPPS(0.001)QPLNETAEEESR 183.67 7.949199999999998e-35 50388900.0 1102.37 1358.98 1408.5 1582.9299999999998 1588.6399999999999 1240.07 1489.99 1458.67 638.71 1084.29 True False 1128.0530761613772 1199.8699898273378 1217.2334363366908 1306.5009907761744 1444.9477924971727 1227.5960216934732 1377.598854702169 1419.9813331720798 1083.844220467306 1223.4691833789936 0.9220118426243521 0.9807112480867893 0.9949032250856692 1.0678658755979962 1.1810250818958075 1.0033730627387623 1.1259775672465226 1.1606187981378953 0.8858778260960611 1.0 10.256762048076764 -5.531296202797588 2.2424414521158598 1.07266547358201 0.9486550120353819 0.21708122116220796 0.08308339114948014 0.4294437922822455 4.264536685339653 0.02342107045438104 0.05642172765373949 2.9424141282619326e-06 5.531296202797588 -0.12401046154662809 APVSSTESVIQSNTPT(ph)PPPSQPLNETAEEESR ddPTM_A459_Selumetinib_30min_R2 4 APVSSTESVIQSNTPTPPPSQPLNETAEEESR 32 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 APVSSTESVIQSNTPT(0.999)PPPS(0.001)QPLNETAEEESR;APVSSTESVIQSNT(0.003)PT(0.996)PPPSQPLNETAEEESR;APVSSTESVIQSNT(0.001)PT(0.998)PPPSQPLNETAEEESR;APVSSTESVIQS(0.005)NT(0.066)PT(0.925)PPPS(0.003)QPLNETAEEESR 130.7 1.2482e-18 47548400.0 24091.3 21090.6 32252.8 33290.3 32029.300000000003 17606.7 22586.0 26954.199999999997 23125.1 24092.100000000002 True False 22752.401991115017 22708.181203032393 30177.689962193475 28756.103711029344 28005.49298842499 20031.86310729065 23636.293753309958 27032.63225949198 27750.766169280265 23396.498474206746 0.9724703897977808 0.9705803297047555 1.289837878751925 1.2290772374648815 1.1969950554481212 0.8561906444836005 1.0102491951677115 1.1554135884604209 1.1861076647804303 1.0 14.514005011413984 APYS(ph)PTTSK ddPTM_A459_Selumetinib_30min_R1 4 APYSPTTSK 9 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 APY(0.001)S(0.935)PT(0.027)T(0.027)S(0.01)K;APYS(0.951)PT(0.043)T(0.005)S(0.001)K;APYS(0.943)PT(0.053)T(0.004)SK;APYS(0.637)PT(0.214)T(0.127)S(0.022)K 137.89 0.0025136 203499000.0 27377.9 33344.2 29054.6 32318.4 30039.699999999997 25763.6 30140.0 29282.9 15892.199999999999 26191.4 True False 28015.751801880113 29440.245562701974 25109.1449054938 26674.59813150342 27322.614438939796 25504.441575477158 27866.515534146805 28506.222367735485 26967.902679636325 29553.3213158404 0.9479730383760231 0.996173839416221 0.8496217611939085 0.9025922280080918 0.9245192493574332 0.8629974716854222 0.9429233092393755 0.9645691617224872 0.91251681634787 1.0 14.851032654677478 -10.640863263099684 4.900191137696898 1.0000037058925013 0.9222075778428402 0.23402133579185236 0.0419726889848926 1.7580172374626196e-06 3.164526490961615e-07 0.04204416671543904 0.010196722488058179 2.286318533680622e-11 10.640863263099684 -0.07779612804966107 APYS(ph)PTTSK ddPTM_A459_Selumetinib_30min_R2 3 APYSPTTSK 9 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 APY(0.009)S(0.454)PT(0.239)T(0.239)S(0.058)K;APYS(0.925)PT(0.074)T(0.001)SK;APYS(0.949)PT(0.05)T(0.001)SK 135.8 0.0026956 176735000.0 1044537.0 901851.0 1038203.0 1019997.0 1070152.0 798273.0 778118.0 891802.0 735145.0 847553.0 True False 986485.8151529097 971020.0717919801 971406.1492899582 881071.6490070311 935709.938479736 908227.8597492005 814302.0288115656 894396.9961742319 882194.5416675184 823081.9426828445 1.1985268586229076 1.1797368177303582 1.180205880988774 1.070454353712546 1.13683691739097 1.1034476795698154 0.9893328799771008 1.0866439291073926 1.0718186075033986 1.0 19.65067654107073 -2.160789290437939 0.1877030197599222 0.9961321945250792 1.794949231406493 0.7155413230764495 0.036924830661165135 23.786847599612425 0.3398297333814077 0.08058350073129877 5.221489761201385 0.006905747733612307 2.160789290437939 0.7988170368814138 APYTCGGDSDQYVLMS(ph)SPVGR ddPTM_A459_Selumetinib_30min_R2 1 APYTCGGDSDQYVLMSSPVGR 21 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 APYTCGGDS(0.005)DQY(0.004)VLMS(0.495)S(0.495)PVGR 53.519 0.03885 2796000.0 10762.0 7276.9 9465.2 10037.0 11210.0 8305.6 9407.0 7647.0 8900.1 12451.0 True False 10163.891123699419 7835.014831078606 8856.219336930553 8669.943285209245 9801.699581328478 9449.621009269951 9844.444139616871 7669.251503970997 10680.368689571555 12091.507278416912 0.8405809871066904 0.6479766873286298 0.7324330319627496 0.7170275041462294 0.8106267775916 0.7815089377762959 0.8141618669153844 0.6342676167147872 0.8832950635224601 1.0 13.561706475878157 -8.512884871743836 6.502378957494831 0.9999407022883319 0.7482843611352483 0.6144383866982088 0.06493476714804601 0.07779606438823622 18.751215378944732 0.06076415617992162 0.01573351756422281 3.0698356712751313e-09 8.512884871743836 -0.25165634115308355 APYTCGGDSDQYVLMSS(ph)PVGR ddPTM_A459_Selumetinib_30min_R1 1 APYTCGGDSDQYVLMSSPVGR 21 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 APYTCGGDSDQYVLMS(0.147)S(0.853)PVGR 194.1 1.7572e-16 8137900.0 2606.2 3260.4 2847.5 2694.6 3270.7 2723.6 2959.6 2808.7 1533.8 2246.3 True False 2666.919389217579 2878.6708522811614 2460.825140197891 2224.038693906541 2974.865762488985 2696.2030568309406 2736.354989212369 2734.2041520566145 2602.7465756802817 2534.634485814895 1.0521909191021497 1.1357341140869301 0.9708796885586152 0.8774593363869204 1.1736862964414982 1.0637443276023686 1.0795856382947542 1.0787370594689738 1.0268725491768445 1.0 11.307561998942917 -5.24339375322842 24.783007907045363 1.0387895424125864 1.0939625030558406 0.08802202955472671 0.07606284634961437 2157.488884752168 2962978.5953732696 0.02027859211257402 0.053409914129648586 5.709607401974163e-06 5.24339375322842 0.055172960643254276 APYTCGGDSDQYVLMSS(ph)PVGR ddPTM_A459_Selumetinib_30min_R2 1 APYTCGGDSDQYVLMSSPVGR 21 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 APYTCGGDSDQYVLMS(0.013)S(0.987)PVGR 180.03 2.8769e-14 4958000.0 15305.0 16045.0 18667.0 22426.0 25969.0 19156.0 17637.0 19944.0 16648.0 21130.0 True False 14454.409370769341 17275.59990719349 17465.985543092876 19371.540112992203 22706.5420541944 21794.565119145533 18457.15544705249 20002.033738093065 19978.065183985265 20519.921997666803 0.7044085924114558 0.84189403396162 0.8511721216620038 0.944035757796488 1.106560836672587 1.0621173473088086 0.8994749321732871 0.9747616847845414 0.9735936221520165 1.0 14.324737626391435 -5.4219591655742665 1.394340763182028 0.9993065377176293 0.7338730768510356 0.7158070272736023 0.05914569330703849 0.31403035540651547 1.0644033301978548 0.02036777627046111 0.08351785423599921 3.7847816935560874e-06 5.4219591655742665 -0.2654334608665937 AQAAAPAS(ph)VPAQAPK ddPTM_A459_Selumetinib_30min_R2 1 AQAAAPASVPAQAPK 15 0 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 AQAAAPAS(1)VPAQAPK 122.01 0.0016085 5073400.0 56733.0 64486.0 64831.0 66993.0 68063.0 51747.0 48783.0 51432.0 44852.0 60970.0 True False 53580.00698019323 69431.8688448289 60659.844042655684 57868.43783062892 59512.317449059825 58874.679537503915 51051.50616168065 51581.65860497406 53823.653269588394 59209.63768091557 0.9049203656495795 1.1726447173853956 1.024492741697819 0.977348284792512 1.005112001694309 0.9943428442305835 0.8622161553630914 0.8711699754514769 0.9090353425171662 1.0 15.853544405112965 -7.111675284473591 4.341825243757467 0.9003901965548464 1.022034663900239 0.3279715913562773 0.07151565536052286 0.24459918153768434 7.622064717881301 0.02770287805819035 0.021340801156830673 7.732585229106918e-08 7.111675284473591 0.12164446734539247 AQAEAQQPTFDALRDELR ddPTM_A459_Selumetinib_30min_R1 2 AQAEAQQPTFDALRDELR 18 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 133.9 0.0011632 26274000.0 4035.4 4541.0 5511.5 5756.8 5584.9 4522.8 4710.2 4479.9 2993.0 4228.8 False True 4129.41696847848 4009.3376089463754 4763.0685725024305 4751.482948519694 5079.746781094182 4477.304738373835 4354.905821796225 4361.07849923396 5078.902399928991 4771.607672000191 0.8654141858120298 0.8402487975851789 0.9982104355419101 0.9957824018938966 1.0645776288151585 0.9383220595956941 0.9126705549055983 0.9139641812600778 1.0644006693450525 1.0 12.220259712245076 -5.260394510553685 24.98708680059233 0.9817535953482954 0.852831481099697 0.5199391649850508 0.05105070581995825 74.61794841797128 1784357.2363626203 0.01400208252526419 0.03297460730680466 5.490419008255391e-06 5.260394510553685 -0.12892211424859845 AQALRDNS(ph)T(ph)MGYMMAK ddPTM_A459_Selumetinib_30min_R1 1 AQALRDNSTMGYMMAK 16 1 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 2 AQALRDNS(1)T(0.999)MGY(0.001)MMAK 49.708 0.04492 0.0 1834.6 1676.7 2026.2 1942.4 1859.3 1791.8 2123.9 1493.6 1071.9 1810.9 True False 1877.3426104898197 1480.3911845233167 1751.0531691199183 1603.1963033637887 1691.126643286077 1773.7761188242314 1963.6925130383006 1453.9848761034507 1818.9360115215113 2043.3466546597492 0.9187587462013038 0.724493409450305 0.8569535497693108 0.7845934020582265 0.8276259142958186 0.8680740073052334 0.9610178031026692 0.7115703411301804 0.8901749526315171 1.0 10.996718263345851 -6.724539248127703 4.501571916808751 0.8731332154136863 0.8159553198669901 0.11352043714680338 0.08476279207222272 0.5228100896341946 23.633859840046647 0.028239682796474666 0.02723514102211204 1.8856485516691263e-07 6.724539248127703 -0.05717789554669617 AQAVS(ph)EDAGGNEGR ddPTM_A459_Selumetinib_30min_R1 2 AQAVSEDAGGNEGR 14 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 AQAVS(1)EDAGGNEGR;AQAVS(1)EDAGGNEGR 142.4 0.00054645 15988300.0 1756.62 2210.46 2562.12 2324.76 2288.4 2172.56 2276.26 1927.12 1186.12 1676.8799999999999 True False 1797.5458282124873 1951.6583155850244 2214.1981767177595 1918.7843071499176 2081.414624049834 2150.70601892665 2104.55987557256 1876.0065174320303 2012.7590092227783 1892.1238821944003 0.9500148722438694 1.0314643422404133 1.1702183971959763 1.014090211114823 1.100041410415423 1.1366623714047506 1.1122738290961087 0.9914818660056879 1.0637564633920644 1.0 10.885790833369322 -1.5359127682013707 24.951853755832325 1.0629512142749196 0.005313288812869077 0.0 0.06778849152940153 0.0 0.0 0.01564930265583853 0.0 0.029113018194651147 1.5359127682013707 -1.0576379254620505 AQAVS(ph)EDAGGNEGR ddPTM_A459_Selumetinib_30min_R2 2 AQAVSEDAGGNEGR 14 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 AQAVS(1)EDAGGNEGR;AQAVS(1)EDAGGNEGR 208.38 6.030499999999998e-06 18079700.0 30500.4 31517.5 35082.2 29954.0 35626.8 25913.2 28489.0 26027.2 25673.9 29451.8 True False 28805.309870775127 33934.79090526461 32825.04944661128 25874.21352646786 31151.04287636692 29482.50808339122 29813.794949882555 26102.934842965085 30809.397388702502 28601.450009033757 1.0071276058268717 1.1864709969091187 1.1476708151594937 0.9046469153939923 1.0891420842834147 1.030804664591452 1.0423875342147297 0.9126437587856728 1.077197043470571 1.0 14.803800668784382 -5.730437718443343 24.99259208666831 1.0102267600278076 1.1210279941705181 0.31346623502485327 0.07135160319105656 226.18641422993247 182342.9816243558 0.01862448317088325 0.032254332006885815 1.8602113143653138e-06 5.730437718443343 0.11080123414271048 AQAVS(ph)EEEEEEEGK ddPTM_A459_Selumetinib_30min_R1 4 AQAVSEEEEEEEGK 14 0 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVS(1)EEEEEEEGK;AQAVS(1)EEEEEEEGK;AQAVS(1)EEEEEEEGK;AQAVS(1)EEEEEEEGK 213.51 1.9362e-06 214429900.0 13178.0 14734.7 12770.899999999998 13845.1 11030.2 12095.100000000002 12476.7 11877.900000000001 7252.700000000001 11277.1 True False 13485.021760075675 13009.554474023807 11036.681925532304 11427.313189714787 10032.520357539976 11973.434275472138 11535.572473951208 11562.85950714326 12307.30218375042 12724.625633256093 1.0597578387557642 1.0223919232659424 0.8673482618370861 0.8980471032365187 0.7884334397484952 0.9409655435503973 0.9065549593697069 0.9086993865598267 0.9672034791801662 1.0 13.635335591450433 -5.151737712134942 4.696946215761568 0.9028629496685305 1.050426706617867 0.4817919119688684 0.054546497105091074 0.17291654872832052 5.9277884061440025 0.0139168258070701 0.04021514019567344 7.051187899315765e-06 5.151737712134942 0.14756375694933643 AQAVS(ph)EEEEEEEGK ddPTM_A459_Selumetinib_30min_R2 4 AQAVSEEEEEEEGK 14 0 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVS(1)EEEEEEEGK;AQAVS(1)EEEEEEEGK;AQAVS(1)EEEEEEEGK;AQAVS(1)EEEEEEEGK 195.38 0.00012386 444311900.0 221824.0 138882.0 156870.0 160542.0 151712.0 134851.0 183016.0 189134.0 130723.0 136202.0 True False 209495.9101118288 149533.80282398517 146777.15498714187 138675.90264960253 132652.58223751164 153425.5011945028 191526.60663932387 189684.34862718082 156871.25270579712 132269.49436470465 1.5838565885357432 1.130523735213487 1.1096825892630653 1.0484345110387554 1.0028962677648916 1.1599462289578657 1.448002863844255 1.434074799622104 1.1859972207443268 1.0 17.01312084214959 -7.060614659603068 22.644659873672044 1.3033040092287793 1.153883196494044 0.037168372007463146 0.1910722159039187 204.25465003888698 76304.58846632182 0.07350611614319269 0.0569378762807092 8.697317818255752e-08 7.060614659603068 -0.1494208127347354 AQAVS(ph)EEEEEEEGKSSSPK ddPTM_A459_Selumetinib_30min_R1 2 AQAVSEEEEEEEGKSSSPK 19 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVS(0.99)EEEEEEEGKS(0.006)S(0.002)S(0.002)PK;AQAVS(1)EEEEEEEGKSSSPK 95.122 0.00096508 153850000.0 1769.63 3108.1000000000004 3089.2 3729.1000000000004 2031.76 2678.3 2264.8 2155.39 1050.53 1688.0500000000002 True False 1810.8589358994325 2744.2022070835114 2669.7036077609564 3077.882688876598 1847.987666736362 2651.3587337018316 2093.9643125990606 2098.222055506571 1782.6726823245576 1904.7276604994147 0.9507180335820975 1.4407320605424445 1.4016195927248554 1.6159174630086408 0.970210967720091 1.391988360691235 1.0993510285087311 1.1015863837229216 0.9359199844124411 1.0 10.895369019423006 -7.5364273620526205 1.043814840382008 0.9681429705638811 1.3241996286022806 0.3008960793179687 0.19646286667569138 0.6551976746405487 1.318723575447538 0.15777319321469588 0.07268836982400981 2.9078542720996637e-08 7.5364273620526205 0.3560566580383995 AQAVS(ph)EEEEEEEGKSSSPK ddPTM_A459_Selumetinib_30min_R2 3 AQAVSEEEEEEEGKSSSPK 19 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVS(0.995)EEEEEEEGKS(0.003)S(0.001)S(0.001)PK;AQAVS(1)EEEEEEEGKSSSPK;AQAVS(1)EEEEEEEGKSSSPK 143.17 4.3655e-05 141068800.0 204494.0 204027.0 193653.0 168217.0 143141.4 97487.6 90832.0 109392.3 60739.9 153595.0 True False 193129.04213434234 219675.2148497948 181193.576813444 145305.55440948915 125158.69763164787 110915.63199567837 95055.86798019357 109710.61348212977 72889.57721460503 149160.31326226384 1.2947749834419406 1.4727457327308429 1.2147572826215314 0.9741569404859255 0.8390884605584417 0.743600154557593 0.6372731854823867 0.7355214740614623 0.488666023960714 1.0 17.186504206571435 -5.908842528130101 1.2446567281493202 0.6986135780346316 1.4083845871663943 0.8095222235076617 0.12916303552639344 0.1781273407979991 0.5578140705490955 0.04461830320043894 0.0947233919195678 1.2335520287153572e-06 5.908842528130101 0.7097710091317626 AQAVSEDAGGNEGR ddPTM_A459_Selumetinib_30min_R2 1 AQAVSEDAGGNEGR 14 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 136.01 0.010195 0.0 7722.8 7567.2 8610.4 9625.6 10081.0 8051.0 6535.8 5783.2 6797.0 5706.6 False True 7293.597692817868 8147.579907616983 8056.416238294687 8314.576674913838 8814.534654716534 9159.952170298642 6839.72765044201 5800.028154539703 8156.5899240478075 5541.835630472574 1.3160978020915994 1.4701951575063599 1.4537450721193053 1.5003289937353883 1.5905442244170067 1.6528733042768966 1.2341989381339264 1.046589711655723 1.4718209755622549 1.0 12.436148206124011 -7.389980000112744 6.271682141067231 1.1847788332214035 1.4976711128142302 0.5308201893355475 0.14298785464545896 0.19421794476717147 9.070890803458125 0.05974540826595256 0.03988656755806538 4.073990386854322e-08 7.389980000112744 0.3128922795928266 AQAVSEEEEEEEGKS(ph)SSPK ddPTM_A459_Selumetinib_30min_R2 1 AQAVSEEEEEEEGKSSSPK 19 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVS(0.405)EEEEEEEGKS(0.409)S(0.138)S(0.047)PK 67.153 0.011681 30186000.0 80350.0 92202.0 83560.0 80212.0 61140.0 36987.0 45770.0 46936.0 32974.0 72573.0 True False 75884.46866653486 99273.59692384253 78183.84057324911 69286.9872265821 53459.046601465 42081.62351544355 47898.39569153441 47072.5759893269 39569.72137053881 70477.62892270111 1.0767171062148513 1.408583098513777 1.1093426633151926 0.98310610452822 0.7585250443101333 0.5970919305698846 0.6796255269039869 0.6679080540713912 0.5614508032603982 1.0 16.104877768067112 -6.012488693194998 1.6919259417853547 0.6778745462546554 1.2407843170815829 0.722113744485058 0.13715474818281595 0.16953286622557304 0.976902727182026 0.043471098862209546 0.07178333259272297 9.716532481241542e-07 6.012488693194998 0.5629097708269275 AQAVSEEEEEEEGKSS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 AQAVSEEEEEEEGKSSSPK 19 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVSEEEEEEEGKS(0.082)S(0.459)S(0.459)PK;AQAVSEEEEEEEGKS(0.034)S(0.582)S(0.384)PK 98.684 0.00078717 14033900.0 2624.4 3327.2 3747.8999999999996 4365.8 2309.7 2910.3 2674.2 2524.0 1959.96 2581.2 True False 2685.5434138065425 2937.649877226684 3238.9557657410624 3603.3949862158283 2100.788042810656 2881.0250243409764 2472.4829409892286 2457.055320892547 3325.908970185374 2912.5221630171427 0.9220679752783518 1.0086274757076907 1.1120793540625835 1.2372077479688588 0.7212951267757584 0.9891856140783706 0.8489147215374085 0.8436177249024714 1.141934304369377 1.0 11.508053312747723 -6.255482342946169 24.99984123336526 0.9158280275208179 1.0686181636956396 0.23313259282848964 0.12903963323659196 729.0292848174881 3059507.8665598957 0.038510494348378464 0.0484134737714585 5.552871928992545e-07 6.255482342946169 0.15279013617482162 AQAVSEEEEEEEGKSS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 AQAVSEEEEEEEGKSSSPK 19 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVSEEEEEEEGKS(0.089)S(0.456)S(0.456)PK;AQAVSEEEEEEEGKS(0.084)S(0.458)S(0.458)PK 76.52600000000002 0.0047532 75537000.0 95178.0 94900.0 86194.0 66394.0 54710.0 44139.0 58047.0 52532.0 36010.0 70152.0 True False 89888.38778772193 102178.52484840532 80648.37188093136 57351.02266396156 47836.840686394346 50218.74659605162 60746.30051794843 52684.85942285924 43213.00620346646 68126.5294832145 1.3194329502704123 1.4998345816746879 1.18380273430488 0.8418309739099819 0.7021763922112123 0.7371393637250356 0.8916687959705263 0.7733383723273342 0.6343051162486354 1.0 16.055929094096342 -5.648486776124858 2.709372688243561 0.7794936628747302 1.4062895177085377 0.853561470121861 0.10465712251646359 0.08666472771478566 1.278244678494649 0.029020039139729906 0.05710192042578956 2.2465351799197865e-06 5.648486776124858 0.6267958548338075 AQAVSEEEEEEEGKSSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 AQAVSEEEEEEEGKSSSPK 19 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 AQAVS(0.001)EEEEEEEGKS(0.007)S(0.076)S(0.916)PK;AQAVSEEEEEEEGKS(0.017)S(0.235)S(0.748)PK;AQAVSEEEEEEEGKS(0.075)S(0.075)S(0.851)PK;AQAVS(0.001)EEEEEEEGKS(0.02)S(0.101)S(0.878)PK 88.709 0.0016909000000000002 354080000.0 12632.7 18697.1 23556.300000000003 26331.799999999996 11808.3 18049.1 12632.7 12071.300000000001 10034.0 14634.4 True False 12927.017331044784 16508.03483995402 20357.483845493793 21733.445439103492 10740.241349924692 17867.54244127159 11679.805268354887 11751.129910891517 17026.96514563564 16512.867791127414 0.7828450814576645 0.9997073221178462 1.2328254609070475 1.3161520890260603 0.6504164803944938 1.0820375156683604 0.7073153746577323 0.7116347117613064 1.0311331357466846 1.0 14.011303074528072 -6.265368318024455 24.99978815158343 0.8524299708334901 1.0876516136500667 0.2400739862919694 0.19027652349301227 492.7340096766547 3135255.582340394 0.05951898802909784 0.0700125687956753 5.427898051096617e-07 6.265368318024455 0.23522164281657654 AQEEAERLEADR ddPTM_A459_Selumetinib_30min_R1 1 AQEEAERLEADR 12 1 P15311;E7EQR4 P15311 EZR Ezrin 0 136.27 0.0040033 5469300.0 2236.5 1956.9 3644.7 3626.8 2907.4 2578.7 2224.2 2139.4 1399.3 1937.9 False True 2288.6060985285535 1727.7852382618712 3149.7697589040376 2993.4474634677676 2644.4261833431606 2552.760619272265 2056.4268032863065 2082.656162249412 2374.5098991716122 2186.648341744507 1.0466274136712375 0.7901523099427341 1.4404555587530607 1.368966105029763 1.209351377109608 1.1674307983311454 0.9404469680962464 0.9524422022920566 1.0859130175807004 1.0 11.094505508516713 -7.248130694474356 21.524654399831658 0.9907374465754231 1.176267178653255 0.20470899422472877 0.16944970719596975 215.0083173546205 347741.4028105521 0.07158462392073937 0.05495537997511601 5.647669909982921e-08 7.248130694474356 0.18552973207783197 AQEEAERLEADR ddPTM_A459_Selumetinib_30min_R2 1 AQEEAERLEADR 12 1 P15311;E7EQR4 P15311 EZR Ezrin 0 101.71 0.034604 11248000.0 43320.0 67939.0 62276.0 74734.0 43450.0 26324.0 32830.0 32894.0 23109.0 70326.0 False True 40912.44782369998 73149.70284168384 58269.229960982004 64555.10027665909 37991.422552071585 29949.89205452012 34356.660051410865 32989.71609410514 27731.445719408657 68295.50565110825 0.5990503684488948 1.0710763782228008 0.8531927453418957 0.9452320421557863 0.5562799805034475 0.4385338649884367 0.5030588722327345 0.4830437344242696 0.40605081483804273 1.0 16.05950302119512 -6.292437789201915 7.964523413611904 0.528666533418967 0.8807053951310276 0.36409199828953354 0.19216275590739404 0.24205258807711164 55.87712959273363 0.05561081752829704 0.06389252581207149 5.09990646287621e-07 6.292437789201915 0.35203886171206067 AQENYEGSEEVS(ph)PPQTK ddPTM_A459_Selumetinib_30min_R1 2 AQENYEGSEEVSPPQTK 17 0 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 AQENYEGSEEVS(1)PPQTK;AQENYEGSEEVS(0.999)PPQT(0.001)K 225.86 2.0173e-13 22236000.0 1964.02 2525.26 2526.3599999999997 2419.9300000000003 2529.96 2491.12 2450.3 1989.23 1176.0 1815.26 True False 2009.7778446823363 2229.601385238477 2183.29418830214 1997.3346532120752 2301.125564700716 2466.0615945559884 2265.471898252152 1936.4691584703166 1995.5861083583322 2048.266303129745 0.9812092507753515 1.0885310088007856 1.0659230125331225 0.9751342636258544 1.1234503839586691 1.2039750840932417 1.1060436305525885 0.9454186477175341 0.9742805929624885 1.0 11.000187582630994 -7.7618159804000735 24.999999727734693 0.9698871981098954 1.0803774531394161 0.3607808280712601 0.06364046022681533 11.579727753105082 768485.4312653916 0.03514055944808324 0.018512354246361298 1.730549473672197e-08 7.7618159804000735 0.1104902550295207 AQENYEGSEEVS(ph)PPQTK ddPTM_A459_Selumetinib_30min_R2 3 AQENYEGSEEVSPPQTK 17 0 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 AQENYEGS(0.003)EEVS(0.996)PPQT(0.002)K;AQENYEGSEEVS(0.99)PPQT(0.009)K;AQENYEGS(0.001)EEVS(0.999)PPQTK 207.16 5.4734e-09 28293400.0 56101.0 46520.0 61404.0 71366.0 74352.0 55632.0 57093.0 54170.0 48417.0 65443.0 True False 52983.13101009673 50087.93441462396 57453.333491620186 61645.82768678322 65011.23704468643 63294.80302298523 59747.937627633255 54327.625731673754 58101.752884010995 63553.490548665795 0.8336777500761369 0.7881224773369349 0.9040153891724572 0.9699833503177643 1.022937316006339 0.9959296094762493 0.940120473506983 0.8548330746691658 0.9142181237003787 1.0 15.955683744102375 -5.44317700548127 3.6322047980706613 0.9539816225565964 0.8118822051868964 0.6044083385045426 0.046639305761475895 0.17887613335802402 4.441111019869886 0.01442370470236308 0.031959235045193136 3.604317118626958e-06 5.44317700548127 -0.1420994173697 AQFSVAGVHTVPGS(ph)PQAR ddPTM_A459_Selumetinib_30min_R1 2 AQFSVAGVHTVPGSPQAR 18 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 AQFSVAGVHT(0.002)VPGS(0.998)PQAR;AQFSVAGVHT(0.004)VPGS(0.996)PQAR 83.73299999999998 0.0056325 29908000.0 3402.0 4418.7 4454.2 4999.3 5863.7 3911.9 4562.6 4248.9 1934.01 3615.7 True False 3481.2599808603313 3901.3565498021017 3849.3441051692494 4126.266103483625 5333.329370320321 3872.549837721015 4218.439408629668 4136.205369627712 3281.8737154983846 4079.8103149004683 0.853289665979302 0.9562592985152741 0.943510557613549 1.0113867520785191 1.3072493470693216 0.9491985016012908 1.0339792987980083 1.013822959984506 0.8044182111879508 1.0 11.994286362321114 -5.102970628298657 1.5233518369786887 1.0233254474123938 0.8531827464741087 0.13914186896298164 0.11799386059289352 1.28391011097625 4.245036167152363 0.035901941074151754 0.2743362113359789 7.889134706964045e-06 5.102970628298657 -0.1701427009382851 AQFSVAGVHTVPGS(ph)PQAR ddPTM_A459_Selumetinib_30min_R2 5 AQFSVAGVHTVPGSPQAR 18 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 AQFSVAGVHTVPGS(1)PQAR;AQFSVAGVHTVPGS(1)PQAR;AQFSVAGVHT(0.001)VPGS(0.999)PQAR;AQFSVAGVHTVPGS(1)PQAR;AQFSVAGVHTVPGS(1)PQAR 126.97 0.00049655 91814100.0 248978.5 190950.2 287484.0 319598.0 312641.0 191250.4 208244.4 219820.4 166831.9 230492.3 True False 235141.27170990492 205595.46633833405 268987.59242891293 276068.20106269844 273364.24253399816 217593.40660172421 217928.17722845028 220460.04097077402 200202.94167276032 223837.38840808446 1.0505004252516208 0.9185036860933481 1.20170984097846 1.233342664628442 1.221262651776565 0.9721048308740242 0.9736004283213807 0.984911602742822 0.8944124263448093 1.0 17.772091509704524 -6.837083025151449 9.517807190245781 0.96402150388311 1.1237410406097266 0.43915265656146996 0.09044462778576348 0.37469898073839175 43.86335498801825 0.03584214136527995 0.03162868288672265 1.4551808634602888e-07 6.837083025151449 0.15971953672661654 AQGEPVAGHES(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 AQGEPVAGHESPK 13 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 AQGEPVAGHES(1)PK;AQGEPVAGHES(1)PK;AQGEPVAGHES(1)PK 163.9 0.00036288 40068400.0 10755.5 12056.7 8131.6 7189.299999999999 7210.219999999999 7990.400000000001 10073.8 10488.8 6989.8 11416.0 True False 11006.082223440122 10645.095958992239 7027.373383681531 5933.823714875046 6558.056874067732 7910.0238307027275 9313.925155537096 10210.602951575964 11861.180085206694 12881.354801256663 0.8544196160458529 0.8263956798980289 0.545546139525321 0.4606521446250484 0.5091123546591504 0.6140676934021763 0.7230547795041294 0.7926652987292805 0.9208022190375158 1.0 13.652996716966632 -8.029726492907493 1.3882873372070688 0.9892963620889892 0.62829689481439 0.534815615064089 0.11942052863663226 0.37843093698131836 1.3109596872074174 0.12412521614477155 0.04140136714484189 9.338422245981124e-09 8.029726492907493 -0.3609994672745992 AQGEPVAGHES(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 AQGEPVAGHESPK 13 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 AQGEPVAGHES(1)PK;AQGEPVAGHES(1)PK;AQGEPVAGHES(1)PK;AQGEPVAGHES(1)PK 151.11 0.00047443 99575100.0 666631.0 415556.0 502802.0 527407.0 468214.0 429089.0 709518.0 699787.0 527484.0 416909.0 True False 629582.3177553315 447427.8089768595 470452.2667294259 455573.256772178 409392.7714337312 488192.1148678769 742511.9928832457 701823.264314025 632995.5391343879 404871.7539103294 1.5550166482959213 1.105109962983378 1.1619784837685199 1.125228550453727 1.0111665421945022 1.2057944525712732 1.8339436765146537 1.7334458567081565 1.5634470249425774 1.0 18.627105470587885 -7.169323072810763 7.833048146442634 1.593048326188998 1.1752714558449113 0.29822384427443926 0.2468897424487999 0.29652833640672555 22.503884752729657 0.09108492009785286 0.07047977076308723 6.771375957594513e-08 7.169323072810763 -0.4177768703440867 AQGEPVAGHES(ph)PKIPYEK ddPTM_A459_Selumetinib_30min_R1 4 AQGEPVAGHESPKIPYEK 18 1 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 AQGEPVAGHES(0.999)PKIPY(0.001)EK;AQGEPVAGHES(0.986)PKIPY(0.014)EK;AQGEPVAGHES(1)PKIPYEK;AQGEPVAGHES(1)PKIPYEK 152.27 5.4394e-05 568238000.0 33478.0 38727.8 46407.8 47810.2 35001.8 35349.9 35585.0 35258.7 21224.0 31237.699999999997 True False 34257.97226315176 34193.53117193425 40105.87565979831 39461.04607860554 31835.89337006971 34994.31210114116 32900.79480035215 34323.52473960144 36015.577860371835 35247.36307596489 0.9719300757142938 0.9701018228864546 1.1378404555643606 1.1195460492621632 0.9032134773162236 0.992820711884791 0.9334257070364264 0.9737898595599223 1.0217949576185683 1.0 15.105227710265765 -6.262953849481014 24.999560008269363 0.9687585227566206 1.050442675884967 0.29956488568476625 0.059135685531463304 187.65573573810465 3097651.485024807 0.019311942720285146 0.023081682841495154 5.458158594032045e-07 6.262953849481014 0.08168415312834643 AQGEPVAGHES(ph)PKIPYEK ddPTM_A459_Selumetinib_30min_R2 3 AQGEPVAGHESPKIPYEK 18 1 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 AQGEPVAGHES(0.991)PKIPY(0.009)EK;AQGEPVAGHES(0.99)PKIPY(0.01)EK;AQGEPVAGHES(0.994)PKIPY(0.006)EK 79.143 0.0067889 627520000.0 483140.0 424780.0 459570.0 414850.0 385910.0 318560.0 368270.0 372690.0 234541.0 371850.0 True False 456289.01296265895 457359.2601170248 430001.76654198224 358346.71434383315 337428.53572082723 362438.74840024055 385395.2847131614 373774.46619784867 281455.75362308376 361113.72431767156 1.2635604305120836 1.266524170415318 1.19076550567131 0.9923375662914315 0.9344107216041214 1.0036692709064787 1.0672407575795413 1.0350602622597624 0.7794102928513658 1.0 18.462093726151735 -5.686538794508228 3.106337325073238 0.9760394936697849 1.2602150417707567 0.7404291657380309 0.07334907539398378 0.12793425416121376 2.472437407989898 0.021373060720744012 0.039398650223501 2.058075039310854e-06 5.686538794508228 0.2841755481009718 AQGGQTQS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 AQGGQTQSPTK 11 0 B7Z385;A0A087X0J3;A0A087WZ15;E9PDI2;P40123-2;P40123 B7Z385 CAP2 Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 1 AQGGQT(0.004)QS(0.796)PT(0.2)K 92.295 0.025817000000000003 0.0 4498.0 3600.4 4223.9 3047.2 4564.1 3557.0 6614.4 10199.0 5575.0 6453.8 True False 4248.019166920646 3876.539102889336 3952.138872634593 2632.166103286801 3990.716954428304 4046.94446276888 6921.9827061849555 10228.677401464654 6690.155778515011 6267.46202501382 0.6777893747048718 0.618518163718876 0.6305804258344715 0.41997320331286686 0.6367357214931836 0.6457070575964051 1.104431535214558 1.6320286202997936 1.0674425711419064 1.0 12.613665634358682 -7.317742143392931 3.5057354390292095 1.2775457594885824 0.5947385500893407 0.7443329615906489 0.1714069971136692 0.10918575929436702 2.7107068697687664 0.07296365121321746 0.04836326440773177 4.811249252262944e-08 7.317742143392931 -0.6828072093992417 AQGQESDSS(ph)ETSVR ddPTM_A459_Selumetinib_30min_R2 1 AQGQESDSSETSVR 14 0 Q03164-2;Q03164;Q03164-3;A0A3B3ITZ1;E9PR05;H7C5W4 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 AQGQES(0.1)DS(0.016)S(0.862)ET(0.022)SVR 177.39 7.0347e-05 2923000.0 6005.0 8593.6 10545.0 6863.8 9790.8 5764.3 5801.4 8539.7 4311.6 10723.0 True False 5671.266139919629 9252.701487220816 9866.546180527903 5928.938599284574 8560.79217313745 6558.280001894477 6071.176595256015 8564.549113176556 5174.040476169565 10413.399128300107 0.5446123854512634 0.8885380626653495 0.9474856441172947 0.5693567034391026 0.8220939260718533 0.6297924357927743 0.5830158356992776 0.822454705486223 0.4968637437614648 1.0 13.346153447715267 -4.723756262730057 23.396008752542535 0.7391562947307037 0.5446085249789349 0.12019486793808942 0.16475759253333486 7002.634265815999 4347059.004903076 0.03970974067089137 9.275733439793436 1.889051235949954e-05 4.723756262730057 -0.1945477697517688 AQIAICGMS(ph)TWSKR ddPTM_A459_Selumetinib_30min_R2 1 AQIAICGMSTWSKR 14 1 P04090;P04808-2;P04090-2;P04808 P04090 RLN2;RLN1 Prorelaxin H2;Relaxin B chain;Relaxin A chain;Prorelaxin H1;Relaxin B chain;Relaxin A chain 1 AQIAICGMS(0.498)T(0.498)WS(0.005)KR 71.888 0.038103 3381400.0 2843.9 1282.1 7616.6 6546.1 8841.5 6112.8 3035.1 5085.6 6820.0 4319.7 True False 2685.8474230337115 1380.4329473987386 7126.556248327059 5654.509887347638 7730.75172598713 6954.782713526462 3176.238163936555 5100.3982540336 8184.190566721499 4194.979037071524 0.6402528831010982 0.32906790122183927 1.6988300025694627 1.3479232762257138 1.8428582497479884 1.657882590608017 0.7571523327930281 1.2158340265733822 1.9509490975751829 1.0 12.034447885985465 -5.257546971190066 24.997936503246613 1.4369978353215116 0.48466031376519775 0.5249538041751942 0.36119769217994774 254.48737885485005 1634359.6537576842 0.09476994598805719 0.2318283084011594 5.526536323688107e-06 5.257546971190066 -0.9523375215563139 AQIHDLVLVGGSTR ddPTM_A459_Selumetinib_30min_R1 1 AQIHDLVLVGGSTR 14 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 91.845 0.023128 13346000.0 2228.8 2587.6 2599.5 2697.0 2593.9 2685.8 2596.9 2435.4 1533.1 2158.9 False True 2280.726703510143 2284.6425890573964 2246.502178031402 2226.019578960121 2359.2822029902413 2658.783290511285 2401.013742223814 2370.8052807059057 2601.5587268062595 2436.0158444668014 0.9362528198207807 0.9378603157474381 0.9222034344046393 0.9137951971931264 0.9685003520601667 1.091447453656954 0.9856314143758582 0.973230648762398 1.0679564062423792 1.0 11.250307801592433 -6.52798176933949 24.994391019815502 1.020755990356246 0.9295434067396512 0.6406189286434626 0.034006522620908974 91.77647948688148 449512.41657588084 0.011164542334025154 0.011198843938058629 2.964955848782432e-07 6.52798176933949 -0.09121258361659479 AQIHDLVLVGGSTR ddPTM_A459_Selumetinib_30min_R2 2 AQIHDLVLVGGSTR 14 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 ; 119.62 0.0030722 7219700.0 41539.0 34044.0 41513.0 47866.0 43476.0 30028.0 37464.0 41913.0 34038.0 38435.0 False True 39230.42867379209 36655.06533128669 38842.09877593692 41346.56822654437 38014.156199628625 34164.08443295585 39206.15023350765 42034.95989092934 40846.55110118275 37325.28168387712 1.0510417310725324 0.9820439036932994 1.0406377935712943 1.107736267785603 1.018455976342948 0.9153068079245933 1.050391275424533 1.1261793078198414 1.0943400627791287 1.0 15.187865527582385 -7.524066186803993 24.985573006022626 1.083812883281021 1.0191766451915862 0.15858813226677826 0.05515198013751218 65.4927742491162 1377949.325226795 0.026611684969908535 0.015520286993485545 2.991808647986062e-08 7.524066186803993 -0.06463623808943475 AQIS(ph)SPNLR ddPTM_A459_Selumetinib_30min_R1 1 AQISSPNLR 9 0 H0Y507;Q5TCZ1-2;Q5TCZ1-3;Q5TCZ1 H0Y507 SH3PXD2A SH3 and PX domain-containing protein 2A 1 AQIS(0.5)S(0.5)PNLR 93.442 0.024562 10832000.0 3221.2 4142.7 4718.7 4613.8 4543.1 3167.6 4332.3 3737.7 1848.4 3265.7 True False 3296.2476926358936 3657.67075811102 4077.9264579637497 3808.0864417523953 4132.177407149454 3135.7368199506827 4005.511123045259 3638.5640542393307 3136.5997982053923 3684.8844056117646 0.894532183320592 0.9926147893650882 1.1066633329809248 1.033434437170676 1.1213858977113367 0.8509729138789871 1.0870113366229908 0.9874296324460295 0.8512071079973685 1.0 11.847403647519373 -6.7497192053100745 24.999999999882004 0.9627689754600169 1.0321446602049311 0.15048701289719613 0.08740332100173023 491.667695959861 1048762.282846227 0.029330334489853213 0.02909933651351746 1.7794295348814668e-07 6.7497192053100745 0.06937568474491418 AQIS(ph)SPNLR ddPTM_A459_Selumetinib_30min_R2 1 AQISSPNLR 9 0 H0Y507;Q5TCZ1-2;Q5TCZ1-3;Q5TCZ1 H0Y507 SH3PXD2A SH3 and PX domain-containing protein 2A 1 AQIS(0.5)S(0.5)PNLR 97.597 0.019947 0.0 109400.0 70738.0 108400.0 90990.0 87413.0 74412.0 71707.0 75436.0 63048.0 63254.0 True False 103319.98596289878 76163.37714148029 101425.66201699627 78597.00503349489 76431.397457865 84661.57755511903 75041.51758472483 75655.50627089797 75659.3617083076 61427.692666370844 1.6819773212719458 1.2398866673235251 1.6511390484396735 1.2795044323148335 1.2442498511702698 1.378231443836532 1.2216235760684366 1.2316188837142548 1.2316816475466936 1.0 15.906601573671711 -1.5228787477827408 0.09682938244232626 0.8232705778691182 2.8965760801951936 0.5818674399004137 0.12694357822188268 98.51933013074972 0.6818599382977538 1.7377000437994896 27.11337653378535 0.02999999982714011 1.5228787477827408 2.0733055023260754 AQKLPDLS(ph)PVENK ddPTM_A459_Selumetinib_30min_R1 1 AQKLPDLSPVENK 13 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8;A0A2R8Y7F4;A0A2R8YET2 E7EPN9 PRRC2C Protein PRRC2C 1 AQKLPDLS(1)PVENK 96.153 0.0079275 39916000.0 4837.5 5879.5 9066.5 9493.3 7348.7 7155.7 6245.3 5582.4 3748.7 4544.3 True False 4950.204337863571 5191.125406694606 7835.319098719637 7835.473366311495 6684.011382518361 7083.720154855763 5774.211992880128 5434.336617809253 6361.270105784767 5127.605170230435 0.9654027900984249 1.0123878953927563 1.5280659954493956 1.5280960811495883 1.3035347224712275 1.3814870528608623 1.1261030834440464 1.0598196306844416 1.2405928098202013 1.0 12.324069462203658 -7.3412017312058815 7.220156884413399 1.1100058498245438 1.2965741793020689 0.18628139699637392 0.18350016665883925 0.5385967905050351 42.498583615802886 0.08547598790839352 0.05739789637232145 4.5582513450415195e-08 7.3412017312058815 0.1865683294775251 AQKLPDLS(ph)PVENK ddPTM_A459_Selumetinib_30min_R2 1 AQKLPDLSPVENK 13 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8;A0A2R8Y7F4;A0A2R8YET2 E7EPN9 PRRC2C Protein PRRC2C 1 AQKLPDLS(1)PVENK 63.46 0.045191 14186000.0 42971.0 56576.0 51981.0 52891.0 41767.0 25970.0 28187.0 28594.0 15657.0 49471.0 True False 40582.84384654229 60915.19727948761 48636.59905263353 45687.154557935886 36519.85605828244 29547.131767812163 29497.75135148091 28677.203806008456 18788.837493131752 48042.643688905584 0.8447254507751834 1.2679401590373902 1.0123630865856184 0.9509708677519416 0.7601550050984376 0.6150188561466579 0.6139910106215237 0.596911443752019 0.39108666906002576 1.0 15.552027921349293 -6.293991860285941 1.6802857617268068 0.6131802473797836 1.0654888466164099 0.5194278475536294 0.1708557476542331 0.26062135544613374 1.4574893472070547 0.05891995079623448 0.0769508402158416 5.081689667693477e-07 6.293991860285941 0.45230859923662625 AQLDYVDLYLIHSPMS(ph)LKPGEELSPTDENGK ddPTM_A459_Selumetinib_30min_R1 4 AQLDYVDLYLIHSPMSLKPGEELSPTDENGK 31 1 A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 A0A0A0MSS8 AKR1C3 Aldo-keto reductase family 1 member C3 1 AQLDYVDLYLIHS(0.142)PMS(0.798)LKPGEELS(0.027)PT(0.033)DENGK;AQLDYVDLYLIHS(0.108)PMS(0.883)LKPGEELS(0.003)PT(0.006)DENGK;AQLDYVDLYLIHS(0.018)PMS(0.916)LKPGEELS(0.028)PT(0.038)DENGK;AQLDYVDLYLIHS(0.049)PMS(0.824)LKPGEELS(0.119)PT(0.008)DENGK 112.8 4.4479e-12 237900900.0 7823.91 7732.22 5242.5 5422.78 5494.82 6136.77 6242.530000000001 7157.820000000001 3923.37 6290.1900000000005 True False 8006.191880321274 6826.928087788443 4530.5972949912 4475.793271187752 4997.814501189263 6075.039665541347 5771.6509362102615 6967.971361723889 6657.672338392712 7097.5971581391605 1.1280144113476747 0.9618646896520003 0.6383283235222421 0.6306068337585407 0.7041558417355408 0.8559290602418599 0.8131837870780857 0.9817366647434163 0.9380177812371381 1.0 12.793114977622837 -7.757124734711926 22.125590819931972 0.9699080197807981 0.8071973514448199 0.1957076806549276 0.14199899135578237 44.44817059854543 227949.85583982538 0.07736454882395613 0.042481177139146724 1.7493441833194167e-08 7.757124734711926 -0.16271066833597825 AQLEPVAS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 6 AQLEPVASPAK 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK 143.94 0.00079801 985923000.0 48874.7 51131.4 47973.700000000004 47524.899999999994 42438.5 40672.100000000006 42890.3 45150.0 32090.5 45370.0 True False 50013.38541638872 45144.91191765702 41459.13504067131 39225.56836786125 38599.945168125705 40262.97560131209 39655.05013982136 43952.47533213093 54455.23470261319 51193.68144122418 0.9769444980003916 0.8818453888589396 0.8098486741624712 0.7662189407670631 0.7539982294971806 0.7864833016070214 0.7746082919500447 0.8585527372668651 1.0637100745554628 1.0 15.643678136728976 -8.170005117909252 4.488307369353403 1.0310882438037223 0.8174163698761595 0.6215378915446221 0.06451449800271972 0.14900478162372657 5.025319619859409 0.05255023631109864 0.01817088822232806 6.76075008192141e-09 8.170005117909252 -0.21367187392756282 AQLEPVAS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 7 AQLEPVASPAK 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK;AQLEPVAS(1)PAK 146.59 0.00068154 1176127000.0 1605109.0 1429586.0 1470534.0 1548685.0 1538198.0 1219127.0 1648550.0 1519913.0 1118471.0 1329002.0 True False 1515903.4675404243 1539230.6493565063 1375921.4434363612 1337751.4313693622 1344955.815575405 1387050.678116963 1725210.8415398542 1524335.6951948574 1342196.4526908433 1290630.2590981165 1.174545116120032 1.1926193722066536 1.066084909862446 1.0365102026231536 1.0420922693345582 1.0747080105546452 1.3367196603196174 1.1810785346533348 1.0399542729059839 1.0 20.299644324604394 AQLEPVAS(ph)PAKKPK ddPTM_A459_Selumetinib_30min_R1 1 AQLEPVASPAKKPK 14 2 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 AQLEPVAS(1)PAKKPK 87.85 0.024343 25936000.0 4939.9 2106.5 11516.0 11183.0 6566.7 4140.2 3569.0 4289.3 4146.0 2788.2 True False 5054.990058627857 1859.8700007147172 9952.190452860024 9230.098980908799 5972.743144445045 4098.553347000828 3299.787456581617 4175.533830390015 7035.459188140859 3146.092629367892 1.6067518201596938 0.5911682266928038 3.163349470374495 2.9338293776694346 1.8984638559879525 1.3027440160985668 1.0488526071289277 1.32721261650486 2.236253034149987 1.0 11.619345432835388 -6.66334391436289 5.060752725399903 1.384411078860027 2.0859097726977143 0.16937792740410273 0.7312963949236835 0.4256698973489903 17.693745027809026 0.2673611510586683 0.26532721321924463 2.1709813150597188e-07 6.66334391436289 0.7014986938376873 AQLGINEDHS(ph)EGDEK ddPTM_A459_Selumetinib_30min_R1 2 AQLGINEDHSEGDEK 15 0 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1;C9J8U1;C9JLY8 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 AQLGINEDHS(1)EGDEK;AQLGINEDHS(1)EGDEK 223.76 3.3061e-51 3820400.0 2235.5 3112.6 1897.5 2104.0 1935.49 2309.4 2357.2 2425.0 1485.62 2568.5 True False 2287.582800474213 2748.1753449915163 1639.8299222214205 1736.5758969714843 1760.4252712385128 2286.1695327674292 2179.394506207393 2360.681122489867 2520.9886346082553 2898.1919943086687 0.7893137531835224 0.9482378498002383 0.5658113490899292 0.5991928417377763 0.6074218943036045 0.7888261154736815 0.7519841716791655 0.814535795808442 0.8698487331270159 1.0 11.500937455837828 -8.308033666971792 0.9687529530318458 0.9951297423731414 0.7100938666569974 0.42177714787305776 0.1061445742574278 0.5637728574211944 1.121611152749405 0.11048672148499977 0.0384712350801785 4.920013937298764e-09 8.308033666971792 -0.2850358757161441 AQLGINEDHS(ph)EGDEKSEK ddPTM_A459_Selumetinib_30min_R1 1 AQLGINEDHSEGDEKSEK 18 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1;C9J8U1;C9JLY8 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 AQLGINEDHS(1)EGDEKSEK 113.7 0.00063071 14199000.0 1698.7 1752.3 1753.3 1721.7 1619.2 1790.6 1702.6 1643.8 874.06 1564.6 True False 1738.2764049051887 1547.1399013778316 1515.2114901875198 1421.0374153116943 1472.7436458929794 1772.5881897347194 1574.1715112288757 1600.20108418509 1483.2159811834053 1765.4316504945846 0.9846183534877783 0.8763521946286629 0.858266866215429 0.8049234955732166 0.8342116476049306 1.0040537050744105 0.8916638096908892 0.9064078372769597 0.8401435313385728 1.0 10.785805252232949 AQLGINEDHS(ph)EGDEKSEK ddPTM_A459_Selumetinib_30min_R2 2 AQLGINEDHSEGDEKSEK 18 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1;C9J8U1;C9JLY8 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 AQLGINEDHS(0.983)EGDEKS(0.017)EK;AQLGINEDHS(1)EGDEKSEK 96.591 0.0020464000000000003 14839600.0 49749.0 49358.0 47949.0 41129.0 44556.0 32524.0 37389.0 41734.0 23833.8 46976.0 True False 46984.1497410261 53143.599889015626 44864.01354292386 35527.15924851761 38958.476944306094 37003.88577652377 39127.66258489798 41855.43903056436 28601.22597201272 45619.6808216941 1.0299096551040123 1.1649270431489644 0.983435498338452 0.7787682554679982 0.8539839876691921 0.8111386381933398 0.8576925984605117 0.9174864505115152 0.6269492784002912 1.0 15.477368732412346 -5.559048138976973 4.276404837600244 0.8332605909039751 1.0949932053931493 0.5538311485897527 0.0957137698837458 0.13357660129283042 5.4575160360866946 0.024628796994496552 0.04646368729163873 2.760271879436047e-06 5.559048138976973 0.2617326144891742 AQLS(ph)PGIYDDTSAR ddPTM_A459_Selumetinib_30min_R1 3 AQLSPGIYDDTSAR 14 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 AQLS(1)PGIYDDTSAR;AQLS(1)PGIYDDTSAR;AQLS(1)PGIYDDTSAR 247.02 2.7336e-27 145304200.0 7527.719999999999 8383.2 8113.3 8534.7 8639.0 6721.25 8234.2 7787.8099999999995 4144.68 6500.22 True False 7703.101229606687 7401.691046756052 7011.558423166825 7044.274861160897 7857.603975339325 6653.640327406728 7613.087664607544 7581.251980427964 7033.219244549841 7334.58655450461 1.0502434148623894 1.009149049064017 0.955958235827295 0.960418805997263 1.0713083712283005 0.9071595621596868 1.0379709351077042 1.033630447209306 0.9589114795066832 1.0 12.840499929146025 AQLS(ph)PGIYDDTSAR ddPTM_A459_Selumetinib_30min_R2 3 AQLSPGIYDDTSAR 14 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 AQLS(0.998)PGIYDDT(0.002)SAR;AQLS(1)PGIYDDTSAR;AQLS(0.998)PGIYDDT(0.002)SAR 193.41 7.1981e-05 221574000.0 832413.0 884817.0 866289.0 924057.0 982458.0 726961.0 798445.0 745960.0 630934.0 812567.0 True False 786150.8178732586 952679.6187649225 810552.9088841486 798198.8425127611 859032.8427540427 827093.2790550827 835574.2745887524 748130.6200996747 757138.4297688942 789106.0794073888 0.9962549248938121 1.2072896707124292 1.027178639268457 1.011522865356963 1.0886151623608935 1.0481395348977947 1.058887133674424 0.9480735728984798 0.9594887804406449 1.0 19.589859728982177 -7.751129683904812 20.297641591299996 0.96533591683622 1.0652467457560213 0.36499207829834546 0.056288952199309544 20.475390679630486 40314.41543944191 0.026623297063222192 0.015044950580247294 1.773659772408244e-08 7.751129683904812 0.0999108289198013 AQLSVQTS(ph)PVPTPDPK ddPTM_A459_Selumetinib_30min_R1 1 AQLSVQTSPVPTPDPK 16 0 J3KQV8;O43426;A0A0D9SGJ6 J3KQV8 SYNJ1 Synaptojanin-1 1 AQLSVQT(0.027)S(0.973)PVPTPDPK 203.06 4.0348e-07 5720400.0 1806.5 2145.5 2223.8 2314.2 1968.1 1850.8 2000.4 1951.7 1298.6 1553.6 True False 1848.587935162901 1894.3038625841098 1921.820174459022 1910.0684129141687 1790.0857024962777 1832.1826323919447 1849.5082174687197 1899.9345759849389 2203.629354008616 1753.0196933455113 1.0545163537980595 1.0805947416192272 1.0962912634434625 1.0895875386710239 1.0211440917015762 1.0451580432022167 1.0550413235455827 1.0838067496886195 1.257047688838651 1.0 10.775626488022699 -8.019137483663952 24.920946250123468 1.14249163915583 1.064236556496038 0.14249312514424461 0.061452996139019146 1075.3841536921861 1400364.1870353124 0.03726738367083124 0.014600145890882427 9.568911023975138e-09 8.019137483663952 -0.07825508265979186 AQLSVQTS(ph)PVPTPDPK ddPTM_A459_Selumetinib_30min_R2 1 AQLSVQTSPVPTPDPK 16 0 J3KQV8;O43426;A0A0D9SGJ6 J3KQV8 SYNJ1 Synaptojanin-1 1 AQLSVQT(0.226)S(0.774)PVPTPDPK 252.37 1.3619e-29 2292600.0 29169.0 25500.0 30916.0 24105.0 31361.0 20925.0 21916.0 23342.0 17126.0 21219.0 True False 27547.903752758648 27455.768004576737 28926.89821879568 20821.857416555635 27421.150809102797 23807.2288117624 22935.137425730143 23409.92135552388 20551.678540421166 20606.352336417047 1.336864637807536 1.3323934074472221 1.403785480639092 1.010458186709626 1.330713479097518 1.1553344533320695 1.1130129705293594 1.1360536291594006 0.9973467504047644 1.0 14.330801526255534 -6.007011070993628 0.27413557510311276 0.9728160677947228 1.5105279037036035 0.5804634916378633 0.09653643850474654 3.2275108049409753 0.35314942781516895 0.1369938937540314 0.569462363436402 9.83986021763333e-07 6.007011070993628 0.5377118359088806 AQLYLPS(ph)TSPPHEGLDGFAQELSR ddPTM_A459_Selumetinib_30min_R2 1 AQLYLPSTSPPHEGLDGFAQELSR 24 0 I3L465;I3L1Z8;I3L1A6;Q8N137-4;Q8N137-5;Q8N137;Q8N137-3;Q8N137-2 I3L465 CNTROB Centrobin 1 AQLY(0.036)LPS(0.379)T(0.293)S(0.293)PPHEGLDGFAQELSR 51.39 0.021796 9876200.0 11750.0 11601.0 12109.0 14847.0 17608.0 10229.0 11581.0 10734.0 10617.0 13612.0 True False 11096.982038976792 12490.759396905683 11329.92012328234 12824.812987496434 15395.925622482771 11637.951900383165 12119.539447316143 10765.234162890638 12740.696663765717 13218.986191776656 0.8394730032988511 0.9449105412241074 0.8570944820511669 0.9701812833025402 1.1646827827129707 0.8803967060365772 0.9168282099315254 0.8143766856786293 0.9638179871684505 1.0 13.690323915534142 -3.70636548288198 1.1174908142176228 0.9462429202743591 1.3060051026710402e-08 0.11137323073537053 0.09051678484589702 41.14644908642599 6.593182829255104 0.029285888831542716 79.57270000330249 0.00019662309009511224 3.70636548288198 -0.946242907214308 AQLYLPST(ph)SPPHEGLDGFAQELSR ddPTM_A459_Selumetinib_30min_R1 1 AQLYLPSTSPPHEGLDGFAQELSR 24 0 I3L465;I3L1Z8;I3L1A6;Q8N137-4;Q8N137-5;Q8N137;Q8N137-3;Q8N137-2 I3L465 CNTROB Centrobin 1 AQLY(0.002)LPS(0.262)T(0.368)S(0.368)PPHEGLDGFAQELSR 77.689 0.00046661 33598000.0 2385.7 2825.4 3019.8 3130.8 3131.0 2255.9 2854.3 2243.0 1361.3 2245.7 True False 2441.282168235891 2494.600854507177 2609.727746574042 2584.0645523946405 2847.801602822948 2233.207694193316 2638.9978529898863 2183.508353709183 2310.026674581802 2533.9574699704 0.9634266546172175 0.9844683204317226 1.0299019527760769 1.0197742397092504 1.1238553277124317 0.8813122243205617 1.0414530962986974 0.8616988957335142 0.911628037154383 1.0 11.307176595100673 -6.782472886496878 24.999959535142644 0.9369643154835072 1.0221347259316513 0.3131475256084695 0.06290769980551662 307.2222842587152 365155.021615022 0.022104978259456346 0.019514657845548133 1.6501640197387332e-07 6.782472886496878 0.08517041044814411 AQLYLPST(ph)SPPHEGLDGFAQELSR ddPTM_A459_Selumetinib_30min_R2 1 AQLYLPSTSPPHEGLDGFAQELSR 24 0 I3L465;I3L1Z8;I3L1A6;Q8N137-4;Q8N137-5;Q8N137;Q8N137-3;Q8N137-2 I3L465 CNTROB Centrobin 1 AQLYLPS(0.023)T(0.488)S(0.488)PPHEGLDGFAQELSR 98.23 1.1013e-05 11883000.0 26056.0 25620.0 30735.0 34000.0 40075.0 24244.0 20755.0 26097.0 23901.0 32956.0 True False 24607.91183043229 27584.971618715917 28757.543561737803 29369.141346728542 35040.42022495438 27583.390934880164 21720.148625252295 26172.93794940906 28681.867849737624 32004.474650028744 0.7688897286870537 0.8619098398070766 0.898547589866843 0.9176573484764939 1.094860034670899 0.8618604503434769 0.6786597456375616 0.8177899570485703 0.8961830545064693 1.0 14.965986006665181 -9.990738677825586 15.909946249734997 0.9999950675209457 0.8682458297936543 0.13385182413818397 0.1019487186335631 0.0 0.0 0.10815531268343843 0.02623151636267778 1.0215539847438875e-10 9.990738677825586 -0.1317492377272914 AQLYLPSTS(ph)PPHEGLDGFAQELSR ddPTM_A459_Selumetinib_30min_R1 1 AQLYLPSTSPPHEGLDGFAQELSR 24 0 I3L465;I3L1Z8;I3L1A6;Q8N137-4;Q8N137-5;Q8N137;Q8N137-3;Q8N137-2 I3L465 CNTROB Centrobin 1 AQLYLPS(0.024)T(0.203)S(0.773)PPHEGLDGFAQELSR 133.46 6.5698e-08 29742000.0 2850.4 3241.9 3112.0 3042.7 3649.5 2514.4 2834.5 2577.8 1184.0 1878.0 True False 2916.8087740870947 2862.3368408815772 2689.4074929923927 2511.3495635528225 3319.403369371557 2489.1074188925363 2620.691382930957 2509.4283701255176 2009.1615240614506 2119.0595932690976 1.3764637782495301 1.3507580673867776 1.2691514205333947 1.1851245578603737 1.566451165373162 1.174628324186278 1.2367237765541017 1.1842179323773494 0.9481382828700414 1.0 11.049208445144643 -7.919118811997544 1.235348680457403 0.9672108772272985 1.3261446401686696 0.6114345803419055 0.10621244149777412 0.3161967831079554 0.8688930563996925 0.09348066309726406 0.03343363432164408 1.2047063180746735e-08 7.919118811997544 0.35893376294137114 AQNEATST(ph)PHR ddPTM_A459_Selumetinib_30min_R2 3 AQNEATSTPHR 11 0 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 AQNEATS(0.005)T(0.995)PHR;AQNEATS(0.003)T(0.997)PHR;AQNEAT(0.002)S(0.224)T(0.774)PHR 172.43 0.00033662 26026980.0 31535.5 25421.5 26228.1 30143.0 34782.9 27980.7 33619.8 35147.9 29692.2 36577.3 True False 29782.88315660874 27371.247306994017 24540.6126009961 26037.47140042467 30413.161138928655 31834.78744149486 35183.18731636986 35250.17456995193 35631.46966938534 35521.218309761374 0.8384533125212172 0.7705604877711159 0.6908719286312385 0.7330117782944812 0.8561970164905913 0.8962189067920154 0.9904836880750055 0.9923695258015697 1.0031038169542081 1.0 15.11639344376305 -6.8044757822980895 1.5181033429771469 0.9985376551331021 0.7553455267788104 0.8834981225355228 0.03834590771096813 0.13054825890870445 0.624851739870535 0.01889303848968799 0.0165328305856295 1.5686433680026153e-07 6.8044757822980895 -0.24319212835429171 AQNEFKDEAQSLSHS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AQNEFKDEAQSLSHSPK 17 1 Q8NEN9 Q8NEN9 PDZD8 PDZ domain-containing protein 8 1 AQNEFKDEAQS(0.004)LS(0.106)HS(0.89)PK 49.482 0.046049 2589700.0 16536.0 9072.0 15160.0 17338.0 11320.0 9367.9 14734.0 14133.0 11810.0 15004.0 True False 15616.995318852783 9767.793228922357 14184.622104959979 14976.534490281745 9897.880397915993 10658.24319167068 15419.16019486713 14174.12469015589 14172.329998970798 14570.795534926301 1.0718011436931314 0.6703678742529113 0.9734967504663241 1.027846040003985 0.6792958129287247 0.7314798403507066 1.0582236335625803 0.9727763083477777 0.9726531379154708 1.0 13.830792027230602 -7.278205158128379 24.90893543550611 0.9986446280871303 0.8551758500473222 0.21493120336095206 0.1326748153902251 1323.1687488459443 1965824.9773491407 0.05620240384276589 0.03800650772599003 5.269808599923275e-08 7.278205158128379 -0.14346877803980806 AQPEEEDEDEVS(ph)MK ddPTM_A459_Selumetinib_30min_R2 1 AQPEEEDEDEVSMK 14 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 AQPEEEDEDEVS(1)MK 161.24 0.00028466 4817200.0 14555.0 10482.0 11117.0 14117.0 12483.0 10854.0 10201.0 10711.0 8091.8 8627.1 True False 13746.091368281468 11285.935695057784 10401.744323274417 12194.24024681668 10914.77394056408 12349.03997719804 10675.366712898025 10742.167236698499 9710.386103782548 8378.013207102289 1.6407340294747328 1.347089747422499 1.2415526290238539 1.4555050159719565 1.302787865183992 1.4739819181389442 1.2742122086711682 1.2821855219316254 1.1590320835912227 1.0 13.032392443133169 -12.93767372655329 0.07989559336257353 4.740160928258377e-12 1.7698886856833573 0.6331970107960312 0.10204872610692936 122.42634436102806 0.9545995600816106 24.6835925132137 4.084289058620401 1.1543201409810352e-13 12.93767372655329 1.7698886856786171 AQPGS(ph)PESSGQPK ddPTM_A459_Selumetinib_30min_R1 4 AQPGSPESSGQPK 13 0 Q05GC8;Q96PN7-2;Q96PN7-3;Q96PN7-4;Q96PN7-5;Q96PN7 Q05GC8 BCAR2;TRERF1 Transcriptional-regulating factor 1 1 AQPGS(0.539)PES(0.365)S(0.096)GQPK;AQPGS(0.972)PES(0.022)S(0.006)GQPK;AQPGS(0.768)PES(0.226)S(0.006)GQPK;AQPGS(0.956)PES(0.034)S(0.01)GQPK 203.11 6.3399e-05 63437200.0 15059.5 16810.6 17427.9 19152.899999999998 16520.300000000003 13643.900000000001 15444.9 14929.699999999997 7675.4 13066.900000000001 True False 15410.357049313985 14842.407136964088 15061.28690460221 15808.205559460623 15026.041781895854 13506.654753670016 14279.878758239673 14533.715857499785 13024.593210963905 14744.163897384446 1.0451835150888222 1.0066631950284457 1.0215083750713068 1.072166971927444 1.019117929404014 0.9160678657449027 0.9685105820597169 0.985726688786877 0.8833727908623163 1.0 13.847856392841072 -6.640854380868933 6.218765529388343 0.9512739269513328 1.034574706177812 0.5827210138098533 0.034964149773220564 0.1539731379665028 7.792910306270781 0.011310778086581581 0.011282460649897389 2.2863652941560606e-07 6.640854380868933 0.08330077922647927 AQPGS(ph)PESSGQPK ddPTM_A459_Selumetinib_30min_R2 3 AQPGSPESSGQPK 13 0 Q05GC8;Q96PN7-2;Q96PN7-3;Q96PN7-4;Q96PN7-5;Q96PN7 Q05GC8 BCAR2;TRERF1 Transcriptional-regulating factor 1 1 AQPGS(0.534)PES(0.447)S(0.02)GQPK;AQPGS(0.75)PES(0.201)S(0.049)GQPK;AQPGS(0.77)PES(0.161)S(0.069)GQPK 140.27 0.00089038 27434600.0 44373.9 42859.5 45853.6 47189.0 47456.0 38125.2 40413.9 42734.0 34381.3 44003.9 True False 41907.77628079593 46146.685834986565 42903.429297624854 40761.776794434525 41494.15301797717 43376.60023389264 42293.226428623624 42858.34886500545 41258.52069378617 42733.393071137245 0.9806798213058595 1.0798741339862084 1.003979001297757 0.9538623981152019 0.9710006633197336 1.0150516286334825 0.98969970295172 1.0029240784521882 0.9654866540811331 1.0 15.383076252443914 -5.514551380296211 24.710220859431058 0.9857920307624456 1.0331893791767934 0.28539879122911893 0.028202981634639458 357.1049372416091 1059654.838190203 0.007258896385501703 0.013380753533908893 3.058078431481594e-06 5.514551380296211 0.04739734841434784 AQPGSPES(ph)SGQPK ddPTM_A459_Selumetinib_30min_R2 1 AQPGSPESSGQPK 13 0 Q05GC8;Q96PN7-2;Q96PN7-3;Q96PN7-4;Q96PN7-5;Q96PN7 Q05GC8 BCAR2;TRERF1 Transcriptional-regulating factor 1 1 AQPGS(0.442)PES(0.448)S(0.111)GQPK 121.18 0.0028905000000000003 26842000.0 17075.0 15742.0 19123.0 19326.0 18854.0 12096.0 15523.0 15184.0 12493.0 14669.0 True False 16126.03985664074 16949.360781492054 17892.646999548127 16693.765460790462 16485.391963101425 13762.11420344458 16244.850258240956 15228.18292615349 14991.949083585288 14245.467855360832 1.1320119507743802 1.189807239297774 1.2560238232410734 1.1718650191266475 1.1572376653742311 0.966069654094628 1.1403521753852206 1.0689844012685652 1.0524013135829402 1.0 13.798215383557647 -6.585340388414082 7.901768857433074 1.055871678601146 1.1891029787164933 0.6354891697097609 0.051531757743163785 0.16921968788514877 18.70345236030236 0.016984320466847842 0.016989390133182385 2.598122425986022e-07 6.585340388414082 0.13323130011534734 AQPPS(ph)SAASR ddPTM_A459_Selumetinib_30min_R2 1 AQPPSSAASR 10 0 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;C9J2Z7;C9K073;C9JHW9;C9JWH9;C9JIH5 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 AQPPS(0.499)S(0.499)AAS(0.002)R 92.943 0.02812 0.0 4819.0 7071.5 6715.6 6063.2 7921.4 5354.3 5052.1 6645.1 4029.4 6639.7 True False 4551.179271985459 7613.861311543704 6283.525607392431 5237.381700396603 6926.242913785495 6091.806223503912 5287.032660546234 6664.436140844474 4835.39259084276 6447.994608987614 0.7058286409919984 1.1808107439995426 0.974492999518651 0.8122497021161302 1.0741700844680095 0.9447598195899196 0.8199499194954104 1.033567263154217 0.7499064258060778 1.0 12.654634822326031 -8.240348389184444 24.95447351485383 0.8749530863220039 0.948130683934621 0.03457206405628166 0.14244624461452718 2523.052818063702 2985241.28858519 0.09106659351912488 0.03434622962876136 5.7497850697275e-09 8.240348389184444 0.0731775976126171 AQPQDLIQWGAEYVLLS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 AQPQDLIQWGAEYVLLSR 18 0 D6RAA3 D6RAA3 ROPN1B 1 AQPQDLIQWGAEY(0.143)VLLS(0.857)R 61.165 0.030791 5306700.0 17107.0 18801.0 19585.0 22813.0 21125.0 12479.0 11491.0 11237.0 8534.0 14048.0 True False 16156.261424746888 20242.976245256752 18324.922422535696 19705.830045379953 18471.088640103826 14197.868976916754 12025.354268984536 11269.69780961451 10241.03845988288 13642.397738912603 1.184268464674939 1.4838283293498422 1.3432332624540768 1.4444550307437853 1.3539473774040622 1.0407165403497778 0.881469262157947 0.8260789653910784 0.7506773117068763 1.0 13.735809609104491 -6.921780693656523 2.357083134968636 0.8490410866201489 1.3778888641107097 0.8616741971004931 0.09449503929656723 0.09631483967108216 1.0865207576693552 0.03724194893522922 0.03107101936744152 1.1973450037969884e-07 6.921780693656523 0.5288477774905608 AQPQDSATFAHT(ph)PPPAQATPAPGFK ddPTM_A459_Selumetinib_30min_R1 1 AQPQDSATFAHTPPPAQATPAPGFK 25 0 A0A0A0MQV9;Q9UPS6-2;Q9UPS6 A0A0A0MQV9 SETD1B Histone-lysine N-methyltransferase;Histone-lysine N-methyltransferase SETD1B 1 AQPQDS(0.023)AT(0.057)FAHT(0.919)PPPAQAT(0.001)PAPGFK 56.335 0.016125 3067100.0 2025.0 2053.6 2053.5 1922.2 2337.0 1860.0 2171.8 2243.8 1147.2 2148.9 True False 2072.178560035913 1813.163557307261 1774.645979068084 1586.5238541628264 2125.618762630861 1841.2900887448782 2007.9793774737896 2184.2871351104177 1946.7146118271085 2424.732247058553 0.8546009822526492 0.7477788772376055 0.7318935858674335 0.6543088854810428 0.8766406126736067 0.759378727683665 0.8281241691364779 0.900836427510782 0.8028575584742074 1.0 11.243609730036912 -8.690068417646708 0.40953095395051814 1.0114550861937341 0.7512391599730427 0.5073990594928218 0.06569642518937797 1.2847720297983185 0.5161145837650754 0.11109698379531771 0.050382522143008424 2.041416319807844e-09 8.690068417646708 -0.26021592622069145 AQPQDSATFAHT(ph)PPPAQATPAPGFK ddPTM_A459_Selumetinib_30min_R2 2 AQPQDSATFAHTPPPAQATPAPGFK 25 0 A0A0A0MQV9;Q9UPS6-2;Q9UPS6 A0A0A0MQV9 SETD1B Histone-lysine N-methyltransferase;Histone-lysine N-methyltransferase SETD1B 1 AQPQDS(0.011)AT(0.271)FAHT(0.718)PPPAQATPAPGFK;AQPQDS(0.001)AT(0.001)FAHT(0.999)PPPAQATPAPGFK 81.808 0.00022244 10986800.0 65925.0 57837.0 75913.0 72823.0 81470.0 60150.0 54619.0 62573.0 54491.0 70570.0 True False 62261.152418684636 62272.911924733555 71028.84022782487 62904.381773318 71235.01024895912 68435.11651266475 57158.89172549525 62755.077070482235 65390.722605750896 68532.46073712013 0.9084914177751291 0.9086630080831735 1.0364262345734303 0.9178771796128762 1.039434590306126 0.9985795895345306 0.8340411406610347 0.9156985813073452 0.9541569338445258 1.0 16.064499869109646 -9.89715798940935 13.38080682112087 0.9999966464551384 0.9467890103286185 0.06658993689231074 0.060654327423196756 0.0 0.0 0.0611250536417731 0.014825003090386823 1.2671907981865294e-10 9.89715798940935 -0.05320763612651991 AQPSMS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 AQPSMSPK 8 0 Q969S3 Q969S3 ZNF622 Zinc finger protein 622 1 AQPS(0.146)MS(0.854)PK;AQPS(0.121)MS(0.879)PK;AQPS(0.16)MS(0.84)PK 127.83 0.0044828 147595000.0 31318.7 39522.0 43321.0 45863.0 29236.2 32433.5 30650.1 29595.6 21357.6 29346.0 True False 32048.364774418143 34894.745866720696 37438.246145219586 37853.8880051346 26591.790872070353 32107.248437261827 28338.138280462903 28810.62854794273 36242.287302613884 33112.84495424651 0.9678529530972284 1.0538129814860764 1.130626081719939 1.1431783665051733 0.8030657259686811 0.9696312256354246 0.8558050001326968 0.8700740932333557 1.0945084106391785 1.0 15.015103347549815 -6.248559656220102 24.906977104076148 0.923738180246788 1.0764893004204876 0.37709372618447845 0.08878930867352489 760.3916274643507 1470454.5828415977 0.02621759050205949 0.03362779294936279 5.642094342262428e-07 6.248559656220102 0.15275112017369963 AQPSMS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 AQPSMSPK 8 0 Q969S3 Q969S3 ZNF622 Zinc finger protein 622 1 AQPS(0.017)MS(0.983)PK;AQPS(0.005)MS(0.995)PK;AQPS(0.08)MS(0.92)PK 109.16 0.01257 206538200.0 312729.0 325616.0 290043.0 276967.0 276420.0 205777.0 250448.0 239779.0 179918.0 247774.0 True False 295348.7741333765 350589.70017954 271381.9491549413 239243.61680527547 241693.6483738466 234120.91389237903 262094.3282532974 240476.71719244987 215906.62732894364 240620.12082583515 1.2274483659957716 1.4570257008278318 1.1278439567876872 0.9942793478124964 1.0044615036528408 0.9729897611589998 1.0892452690729286 0.999404024763627 0.8972924898712874 1.0 17.87639776118163 -5.48470944640405 3.911394246775539 0.9993366775237592 1.3402266500526807 0.8024168450063562 0.06842418460682556 0.08532539759214491 2.763808202580049 0.017949651861198082 0.0377995184973686 3.2755976705801204e-06 5.48470944640405 0.3408899725289215 AQPSSS(ph)EDELDNVFFK ddPTM_A459_Selumetinib_30min_R1 2 AQPSSSEDELDNVFFK 16 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 AQPS(0.003)S(0.089)S(0.908)EDELDNVFFK;AQPSS(0.057)S(0.943)EDELDNVFFK 202.96 4.1514e-07 16624000.0 4931.4 6188.200000000001 5139.799999999999 5199.700000000001 5650.6 5585.0 6393.3 5442.4 2864.8999999999996 5268.1 True False 5046.292025165974 5463.682667183867 4441.843390900481 4291.670005457523 5139.50422769446 5528.8199707742715 5911.04823372464 5298.049872593342 4861.526055982817 5944.311950639478 0.8489278602922419 0.9191446735220709 0.7472426460429344 0.7219792704512813 0.8646087672336176 0.9301025949991557 0.9944041098126993 0.8912805916963001 0.8178450418403467 1.0 12.537294113498106 -6.555066987891813 4.978693989534811 0.9227593610926634 0.8103678740313784 0.38682590367564484 0.06955675314443392 0.22689526910717073 14.106486313436553 0.02480932377125651 0.025369882967466634 2.785691455616956e-07 6.555066987891813 -0.11239148706128499 AQPSVS(ph)LGAPYR ddPTM_A459_Selumetinib_30min_R2 1 AQPSVSLGAPYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 AQPS(0.166)VS(0.834)LGAPYR 80.37100000000002 0.04027 2560400.0 11605.0 12529.0 12302.0 9996.0 11857.0 8522.1 7727.7 10697.0 7907.8 10429.0 True False 10960.040558495806 13489.934012915377 11510.502713404858 8634.527555938197 10367.417657075091 9695.94191907863 8087.053362147053 10728.126499016318 9489.580962393004 10127.887672203833 1.0821645058895975 1.3319592840606576 1.136515637411307 0.8525496959880203 1.0236505372713258 0.9573508546791365 0.7984935875959717 1.0592659443153039 0.9369753367661577 1.0 13.306045688672699 -5.603199002155721 5.561287414667019 0.9477627313305355 1.213628811384892 0.5886760151928366 0.09173534714651191 0.12298004106850562 6.345472712216201 0.023956477600689523 0.042317132454061886 2.4934519170996393e-06 5.603199002155721 0.26586608005435663 AQQCVS(ph)PSSSLCR ddPTM_A459_Selumetinib_30min_R1 2 AQQCVSPSSSLCR 13 0 B9EGE7;Q8TCN5-2;Q8TCN5 B9EGE7 ZNF507 Zinc finger protein 507 1 AQQCVS(0.937)PS(0.063)SSLCR;AQQCVS(0.563)PS(0.436)S(0.001)SLCR 197.06 0.00017734 27055000.0 3631.0 3968.3 4195.1 3782.8 3975.7 4006.8 4202.5 3842.7 2189.36 3210.3 True False 3715.595235303901 3503.68959118738 3625.4284620348253 3122.204991950441 3616.0986369668426 3966.4952298833177 3885.502041547838 3740.7791131512636 3715.184015472281 3622.3732759700647 1.0257350505405525 0.9672359318764846 1.0008434211032387 0.8619224895077442 0.998267809934209 1.0949990317662937 1.072639881517265 1.0326873649291404 1.025621528327271 1.0 11.82271950451263 -6.528810326786426 24.56408820410568 1.048690993177631 0.9622175230274437 0.40628145443288466 0.04635496447333523 121.05793657201214 501324.1008700681 0.015437144484622318 0.015481001340903484 2.959304627260288e-07 6.528810326786426 -0.08647347015018725 AQQCVS(ph)PSSSLCR ddPTM_A459_Selumetinib_30min_R2 2 AQQCVSPSSSLCR 13 0 B9EGE7;Q8TCN5-2;Q8TCN5 B9EGE7 ZNF507 Zinc finger protein 507 1 AQQCVS(0.824)PS(0.161)S(0.015)SLCR;AQQCVS(0.758)PS(0.221)S(0.021)SLCR 204.17 4.3512e-05 29389000.0 67328.0 69700.0 84760.0 75330.0 78291.0 51483.0 69125.0 69901.0 63192.0 69388.0 True False 63586.17929533866 75045.76587917635 79306.63387971015 65069.92404850175 68455.38464957959 58574.315933857266 72339.449468589 70104.4003372665 75832.16573200362 67384.58814832485 0.9436308960644643 1.1136933227815826 1.1769254077081077 0.9656499481049267 1.0158908220808256 0.869253898308695 1.0735310767108595 1.0403625259674347 1.1253636449492608 1.0 16.04013104299694 -5.7919727116174835 24.999997653165686 1.0112164344530705 1.0816445280183486 0.11353976335975624 0.08324235486550953 420.28536186772965 344118.4207884911 0.024186461060256494 0.03587917643162838 1.614459996332855e-06 5.7919727116174835 0.07042809356527813 AQQCVSPS(ph)SSLCR ddPTM_A459_Selumetinib_30min_R2 2 AQQCVSPSSSLCR 13 0 B9EGE7;Q8TCN5-2;Q8TCN5 B9EGE7 ZNF507 Zinc finger protein 507 1 AQQCVS(0.192)PS(0.746)S(0.062)SLCR;AQQCVS(0.226)PS(0.774)SSLCR 241.41 6.8476e-18 29447000.0 78171.0 77773.0 82011.0 86779.0 95785.0 65606.0 75624.0 73167.0 60757.0 85044.0 True False 73826.56876330686 83737.93902038998 76734.50154682553 74959.55049787507 83751.63197123529 74642.6309880279 79140.66584611314 73379.9038565511 72910.09769241897 82588.55874915187 0.8939079441686589 1.0139169430808104 0.9291178186060008 0.9076263302469224 1.0140827402693398 0.9037890007832887 0.9582521725132522 0.8884996295846447 0.8828111156881971 1.0 16.333654313989115 -7.744637249927051 24.919840343770044 0.9142415169193556 0.9473312200946452 0.02880903183623662 0.04967082029971004 571.12964110092 847064.4052076252 0.022237783524618283 0.012795125559237671 1.800374072963495e-08 7.744637249927051 0.033089703175289586 AQQELEEQTRR ddPTM_A459_Selumetinib_30min_R1 1 AQQELEEQTRR 11 1 P26038 P26038 MSN Moesin 0 106.67 0.014866999999999997 10817000.0 3042.9 2609.0 3383.7 3299.4 3231.8 2354.4 2515.3 2730.9 1509.0 1995.8 False True 3113.7936495472995 2303.5370671088053 2924.212125333661 2723.221727408609 2939.4842606206334 2330.716873624162 2325.568895920351 2658.4676607866313 2560.6627870006155 2251.9803707382675 1.3826912925206818 1.0228939368390835 1.2985069334219 1.209256422832786 1.3052885801384588 1.0349632278811036 1.0326772498278745 1.180502146168843 1.1370715394651298 1.0 11.136978536963898 -6.7667049906562555 24.997583764915266 1.0855513614357368 1.2325871573247782 0.4039968492714854 0.10050951237819324 150.9930419482857 716809.2761832438 0.03399768181881382 0.030857015953395 1.7111772959468866e-07 6.7667049906562555 0.14703579588904137 AQQELEEQTRR ddPTM_A459_Selumetinib_30min_R2 1 AQQELEEQTRR 11 1 P26038 P26038 MSN Moesin 0 103.08 0.017558 0.0 24698.0 31884.0 33798.0 31701.0 34975.0 21384.0 25108.0 24995.0 23654.0 28491.0 False True 23325.38403392754 34329.400276781365 31623.47347648003 27383.269112724767 30581.127819532852 24329.45189537526 26275.571750558145 25067.73131185501 28385.46094798099 27668.390801491943 0.8430336336246119 1.2407443758865169 1.1429458873616467 0.9896950389774095 1.105273090832729 0.8793229815903626 0.9496602798143687 0.9060061169333815 1.0259165829929793 1.0 14.755951118538231 -6.751440264658019 24.999498024754224 0.9461490138406288 1.074358978644548 0.21952430537656242 0.10458282079723372 282.80564752103817 707061.2391315517 0.03385371718538104 0.0334740937439629 1.7723918132568598e-07 6.751440264658019 0.12820996480391922 AQQELVPPQQQAS(ph)PPQLPK ddPTM_A459_Selumetinib_30min_R1 2 AQQELVPPQQQASPPQLPK 19 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 AQQELVPPQQQAS(1)PPQLPK;AQQELVPPQQQAS(1)PPQLPK 139.45 8.7546e-05 30984000.0 10779.2 12225.4 13020.5 14897.2 12902.5 10703.3 11240.5 11409.2 6594.9 9893.4 True False 11030.33438732796 10794.044484565726 11252.387616486962 12295.683675077751 11735.471153121385 10595.634519818837 10392.620035221533 11106.590953695426 11191.06362756154 11163.314259876724 0.9880877784631825 0.9669211341081536 1.007979113956362 1.1014366691503972 1.0512533177804653 0.949147741715178 0.9309618804314032 0.9949187754764574 1.0024857642666705 1.0 13.44647778990982 -6.764492959840303 24.986897059751715 0.972401446396751 1.0235206087919826 0.26039320383981235 0.03996535278848234 122.19741873751502 999914.4547799155 0.015628790876818656 0.014371924318163178 1.7199152218128036e-07 6.764492959840303 0.05111916239523162 AQQELVPPQQQAS(ph)PPQLPK ddPTM_A459_Selumetinib_30min_R2 2 AQQELVPPQQQASPPQLPK 19 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 AQQELVPPQQQAS(1)PPQLPK;AQQELVPPQQQAS(1)PPQLPK 141.36 6.949899999999999e-05 38928000.0 120914.0 114474.0 117729.0 141341.0 135854.0 112363.0 112863.0 115022.0 101507.0 120166.0 True False 114194.08393709276 123253.78770807553 110154.44431364346 122090.11197317534 118786.80596983052 127839.98332024187 118111.35313379168 115356.69497708285 121811.23634255119 116696.49535123665 0.9785562419281568 1.0561909964571132 0.9439396100293952 1.0462191825530391 1.0179123684246247 1.0954911965047898 1.0121242525604266 0.9885189322085361 1.0438294310032195 1.0 16.832401708872702 AQQQEEQGS(ph)VNDVKEEEKEEK ddPTM_A459_Selumetinib_30min_R1 1 AQQQEEQGSVNDVKEEEKEEK 21 2 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 AQQQEEQGS(1)VNDVKEEEKEEK 46.504 0.034525 33412000.0 4120.3 4119.0 3611.5 3205.0 2312.7 3650.5 3083.4 4549.6 2705.7 5676.6 True False 4216.2949732918405 3636.745565128849 3121.078136549491 2645.3069153011443 2103.516693340347 3613.779284388803 2850.816655540417 4428.929828816456 4591.375283490767 6405.246904766437 0.6582564319502349 0.5677760153824173 0.4872689816573587 0.412990623879409 0.32840524723176934 0.564190473547495 0.44507521691614943 0.6914534122830904 0.7168147226415449 1.0 12.645038468252677 -8.438750459633303 1.1226255272810317 0.9919846003054034 0.4883556626986228 0.7334463743455703 0.09400667831789127 0.2590798348669721 0.7109052895961033 0.09418820273843134 0.030385906681242927 3.6412419739896633e-09 8.438750459633303 -0.5036289376067806 AQQQEEQGS(ph)VNDVKEEEKEEK ddPTM_A459_Selumetinib_30min_R2 1 AQQQEEQGSVNDVKEEEKEEK 21 2 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 AQQQEEQGS(1)VNDVKEEEKEEK 47.806 0.030941000000000007 57168000.0 85153.0 65254.0 57722.0 58315.0 47292.0 46074.0 84982.0 73579.0 41682.0 51865.0 True False 80420.53715446734 70258.77197531973 54008.22936296175 50372.39640101396 41350.75616415576 52420.27528187053 88933.83138863843 73793.10270834074 50019.56469238791 50367.52268854656 1.5966744612745218 1.394922128883984 1.0722828219471487 1.000096762997409 0.820980543749451 1.0407554805904868 1.7656979466425444 1.4650929561227177 0.9930916198060745 1.0 15.620206153768889 -1.5309737948365014 0.015970949634049242 6.527659118149804e-06 2.7054860090549298 0.05512440348550829 0.29023290170769056 28293.851199535915 35.05109850123843 2341.00518163791 3749.5689746140906 0.029445993044380586 1.5309737948365014 2.7054794813958116 AQRLS(ph)QETEALGR ddPTM_A459_Selumetinib_30min_R1 1 AQRLSQETEALGR 13 1 Q02818 Q02818 NUCB1 Nucleobindin-1 1 AQRLS(0.677)QET(0.323)EALGR 152.07 0.00082173 0.0 2069.6 2577.9 2222.1 2432.2 2449.7 2369.9 1840.0 2363.7 1038.4 1438.5 True False 2117.81765325942 2276.078269566804 1920.351025121592 2007.4619280485003 2228.1250675296615 2346.060957697036 1701.2073186075017 2301.0069976203304 1762.0889582647064 1623.1454871765695 1.3047614462110375 1.4022638682414097 1.1831046818002777 1.2367726392416258 1.372720489403228 1.4453793429065709 1.048092935628783 1.4176221514331953 1.0856013661041726 1.0 10.664576603230156 -8.440363706800929 5.1177046230379295 1.0014858212508853 1.296698916157697 0.45382268108849 0.11507553234917231 0.1743864517681067 7.245507161299207 0.10776542771781289 0.028035071610306866 3.627741165821199e-09 8.440363706800929 0.2952130949068117 AQS(ph)GSDSSPEPK ddPTM_A459_Selumetinib_30min_R1 2 AQSGSDSSPEPK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQS(0.829)GS(0.167)DS(0.002)S(0.002)PEPK;AQS(0.997)GS(0.003)DSSPEPK 126.09 0.0026916 6630900.0 4515.4 5075.0 5544.5 6025.200000000001 4861.0 5154.799999999999 4850.5 4752.9 3517.1000000000004 4059.4 True False 4620.600034561069 4480.816640696511 4791.587353758453 4973.011927011689 4421.323408279254 5102.94739218392 4484.622879840044 4626.837652404985 5968.261821179504 4580.463531904463 1.0087625416897312 0.9782452386065563 1.0460922394389656 1.085700583002789 0.9652567644045751 1.1140679009100678 0.9790762110871845 1.0101243291595952 1.3029820627559987 1.0 12.161277887644028 AQS(ph)LLSTDR ddPTM_A459_Selumetinib_30min_R1 1 AQSLLSTDR 9 0 J3QRY4;O00231;O00231-2 J3QRY4 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 AQS(0.987)LLS(0.012)T(0.001)DR 93.011 0.025134 5722000.0 1321.5 1460.4 1275.8 1694.6 1171.0 1409.9 1330.2 1434.5 396.76 925.15 True False 1352.2883788086222 1289.4156890784589 1102.5533674677679 1398.6699215816907 1065.083256756842 1395.7176860867753 1229.861943049836 1396.4524000873043 673.272741796133 1043.9020142241243 1.2954169647940614 1.2351884290948625 1.056184730410005 1.339847900016982 1.0202904508700088 1.3370198228079255 1.1781392566465405 1.3377236379079234 0.6449577954847995 1.0 10.027770584474801 -8.256258939665214 24.999054759975913 0.8224788880322341 1.2188701425950434 0.5906536066072628 0.13395290732226323 249.85778817022174 1205744.0259060094 0.088730646100752 0.031276647352805685 5.542951266916487e-09 8.256258939665214 0.3963912545628093 AQS(ph)LLSTDR ddPTM_A459_Selumetinib_30min_R2 4 AQSLLSTDR 9 0 J3QRY4;O00231;O00231-2 J3QRY4 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 AQS(0.988)LLS(0.012)TDR;AQS(1)LLSTDR;AQS(0.999)LLS(0.001)TDR;AQS(0.998)LLS(0.002)TDR 127.52 0.0045443 26264600.0 153074.0 156942.0 171513.0 165370.0 148466.0 86445.0 122060.0 111455.0 119972.0 106025.0 True False 144566.75988377305 168978.94675193282 160478.04030923473 142846.32072083838 129814.3737771198 98352.01408042051 127736.03185730147 111779.3155976315 143969.7522977586 102963.78276396707 1.4040544743308057 1.641149365493866 1.5585872624465695 1.3873453061480614 1.2607770450188753 0.955209797467149 1.2405918705426937 1.0856178026585626 1.3982562453808938 1.0 16.651777436940293 -6.164614968779289 2.2103606914125136 1.147343808619091 1.5421526757782134 0.6370349761548759 0.1307227008937339 0.19217914227808766 1.8426983274338535 0.04150799882620701 0.05715442030617697 6.845182497380003e-07 6.164614968779289 0.39480886715912233 AQS(ph)PGAVEEILDR ddPTM_A459_Selumetinib_30min_R1 4 AQSPGAVEEILDR 13 0 E9PHY4;Q9NYM9;H7BXT7;A0A0C4DH16;B8ZZS0 E9PHY4 BET1L BET1-like protein 1 AQS(1)PGAVEEILDR;AQS(1)PGAVEEILDR;AQS(1)PGAVEEILDR;AQS(1)PGAVEEILDR 179.9 0.00011077 36153600.0 9606.49 9438.11 9504.59 8660.95 10270.310000000001 8968.43 10402.98 11244.0 5480.74 9057.61 True False 9830.302526024388 8333.091693541697 8213.918882975757 7148.477668666907 9341.362273870503 8878.215736882914 9618.274843112755 10945.772594340644 9300.415482588314 10220.242472092714 0.9618463116571754 0.8153516627708148 0.8036911947446058 0.6994430600043458 0.9140059347298196 0.868689344810133 0.9411004552363914 1.0709895214550003 0.9099994944331243 1.0 13.319141803724795 -7.14447943489363 1.614447116156942 0.9941877202046336 0.8254556778694515 0.45708935285946606 0.07465958130913704 0.34110790188958956 1.7566461351675722 0.03973903723556439 0.02652058514326594 7.170023269213322e-08 7.14447943489363 -0.16873204233518213 AQS(ph)PGAVEEILDR ddPTM_A459_Selumetinib_30min_R2 4 AQSPGAVEEILDR 13 0 E9PHY4;Q9NYM9;H7BXT7;A0A0C4DH16;B8ZZS0 E9PHY4 BET1L BET1-like protein 1 AQS(1)PGAVEEILDR;AQS(1)PGAVEEILDR;AQS(1)PGAVEEILDR;AQS(1)PGAVEEILDR 212.43 4.5365e-06 28712100.0 64146.0 39931.4 58635.4 71871.0 63139.0 44685.4 55199.0 60720.5 55320.5 50920.1 True False 60581.02211678343 42994.009980311974 54862.86220139646 62082.04581560964 55206.91435017829 50840.408236326286 57765.862874743485 60897.18660218012 66386.14578391728 49449.9044066916 1.2250988721544536 0.8694457652883549 1.1094634632695544 1.2554533029028192 1.1164210530345866 1.0281194442399473 1.1681693537698035 1.2314925040368623 1.3424929042923255 1.0 15.593680111613203 -7.496108345882945 6.648054226638019 1.2127159484994416 1.0980685952335807 0.09176496604505413 0.126881319215134 0.3649783073785328 60.61405492319336 0.05538600047370827 0.03553828361153367 3.190741743541044e-08 7.496108345882945 -0.11464735326586095 AQS(ph)PGSPLHAR ddPTM_A459_Selumetinib_30min_R2 2 AQSPGSPLHAR 11 0 Q13796 Q13796 SHROOM2 Protein Shroom2 1 AQS(1)PGSPLHAR;AQS(0.998)PGS(0.002)PLHAR 112.62 0.0050044 8275500.0 23968.0 17203.1 36007.0 45006.0 52412.0 29482.0 23480.0 24008.0 31957.0 33307.0 True False 22635.954511506006 18522.522453315072 33690.34882145738 38876.10516031956 45827.53599077501 33542.87788905038 24571.866524737332 24077.85930526165 38349.29295318458 32345.340368021225 0.6998211876566132 0.572648865109105 1.0415827577676666 1.2019074376090069 1.4168203354596074 1.037023494185058 0.759672529185401 0.7443996270036669 1.185620324808802 1.0 14.981270273772257 -5.26761450793861 23.902143364768335 1.0471751304151102 0.6362350102709111 0.4271120324325425 0.19092504496646892 257.39924005723805 996326.4203493184 0.056482127618446225 0.12274620034568545 5.399897199965872e-06 5.26761450793861 -0.4109401201441991 AQS(ph)PSYVISTGVSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 2 AQS(0.998)PS(0.002)YVIST(0.036)GVS(0.382)PS(0.581)R;AQS(0.994)PS(0.006)YVISTGVS(0.142)PS(0.858)R 183.46 1.5812e-05 9742200.0 43025.0 39239.0 50465.0 47498.0 58455.0 40024.0 44854.0 43014.0 36258.0 39053.0 True False 40633.84274272139 42248.505126728895 47218.136842137545 41028.69046137979 51111.360305669594 45536.942698302446 46939.79987651489 43139.163618648985 43510.613133165396 37925.438418120284 1.0714139226221064 1.113988575713949 1.2450254713358127 1.0818250802811238 1.3476801439228516 1.2006965403080345 1.2376864140372774 1.1374730370430641 1.147267241935866 1.0 15.210878237674812 -8.80971727351096 1.4119333324885328 1.0005853205054382 1.1857889726552384 0.3132165683518452 0.07968744307842016 1.2634183710887894 4.244882821876533 0.07702040398892043 0.022658530773831006 1.5498252295858628e-09 8.80971727351096 0.18520365214980017 AQS(ph)PSYVISTGVSPSR ddPTM_A459_Selumetinib_30min_R1 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQS(0.896)PS(0.104)YVISTGVSPSR 197.1 1.1013e-06 5662400.0 968.26 1047.4 1211.2 1078.5 1198.3 909.04 960.18 1005.9 519.46 871.11 True False 990.8185740940112 924.7699210769508 1046.7256926453674 890.1602209523503 1089.9139765770476 899.8958829422818 887.752849554647 979.2202643763122 881.485680142704 982.9254538299491 1.0080302328455395 0.9408342387244155 1.064908522377584 0.9056233282838073 1.1088470364972438 0.9155281099251786 0.9031741380748012 0.9962304471420496 0.8967981007186384 1.0 9.940938194877708 AQS(ph)PSYVISTGVSPSR ddPTM_A459_Selumetinib_30min_R2 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQS(0.5)PS(0.5)YVISTGVSPSR 119.48 0.0016802 3904400.0 24183.0 19542.0 25782.0 23766.0 20512.0 13456.0 17942.0 21240.0 16242.0 17964.0 True False 22839.005672219202 21040.808562566235 24123.21418931913 20529.029801363245 17935.099180393376 15309.441858593775 18776.338551398527 21301.804883528715 19490.85383939744 17445.332643922688 1.3091757055246218 1.2060995907633827 1.3827890061885848 1.176763448446757 1.0280743592837884 0.8775666346452282 1.0762958170327301 1.2210604015595816 1.1172532067588483 1.0 14.090553486348705 -6.020639499565079 4.448102915385023 1.0586659462160548 1.2903407351417018 0.5923913763219602 0.09150690850137291 0.1619980569178057 7.857014841095298 0.029845290056823248 0.04174069209136477 9.535873921998318e-07 6.020639499565079 0.23167478892564697 AQS(ph)PVSGPNVAHLTDGATLNDR ddPTM_A459_Selumetinib_30min_R2 1 AQSPVSGPNVAHLTDGATLNDR 22 0 Q5THJ4-2;Q5THJ4 Q5THJ4-2 VPS13D Vacuolar protein sorting-associated protein 13D 1 AQS(0.757)PVS(0.243)GPNVAHLTDGATLNDR 104.82 0.00024887 0.0 3736.3 2648.3 5602.9 6499.5 7813.9 5223.6 3374.4 4533.2 5664.7 5537.1 True False 3528.6514035939567 2851.416094373355 5242.415513976272 5614.256887737125 6832.24802484769 5943.103484880387 3531.3162862467493 4546.3908614883385 6797.798284942417 5377.229535886458 0.656221085606353 0.5302760604403486 0.9749287210057771 1.0440798277753998 1.2705888746706377 1.1052352229372784 0.6567166721598017 0.8454894534716655 1.2641822781741774 1.0 12.392647341400473 -5.303461509055352 6.061561366652065 1.0161110065088763 0.5929514867292875 0.4908268741891534 0.17400583359408564 0.16446158701249902 16.643716518487036 0.04947403891565657 0.10761630568000122 4.972084386978044e-06 5.303461509055352 -0.42315951977958877 AQS(ph)SLGYIPLMR ddPTM_A459_Selumetinib_30min_R2 1 AQSSLGYIPLMR 12 0 Q9BZL6-2;Q9BZL6;Q9BZL6-3 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 AQS(0.973)S(0.027)LGYIPLMR 120.84 0.0039337 2204700.0 18229.0 15791.0 19339.0 18441.0 18323.0 12448.0 19110.0 21462.0 15709.0 14862.0 True False 17215.90515646877 17002.118923932212 18094.74979471115 15929.303987500633 16021.100930301667 14162.599008306739 19998.652865746633 21524.450866774627 18851.238946133148 14432.895443886615 1.1928240749336934 1.178011646383391 1.2537158510613058 1.1036804118364105 1.1100406701198526 0.9812721961001688 1.385629996662764 1.4913466913454156 1.3061300845297832 1.0 13.817073133536653 -7.2840786387106995 24.671035528104206 1.336722268582657 1.1410946729113434 0.22566964341548157 0.1361059155265806 827.1249556414604 901351.606770986 0.055865225333750844 0.03769677131522361 5.19901848174567e-08 7.2840786387106995 -0.1956275956713136 AQS(ph)SPAAPASLSAPEPASQAR ddPTM_A459_Selumetinib_30min_R1 4 AQSSPAAPASLSAPEPASQAR 21 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10;H0YI15 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 AQS(0.361)S(0.361)PAAPAS(0.016)LS(0.263)APEPASQAR;AQS(0.5)S(0.5)PAAPASLSAPEPASQAR;AQS(0.5)S(0.5)PAAPASLSAPEPASQAR;AQS(0.5)S(0.5)PAAPASLSAPEPASQAR 286.21 6.1645e-74 130591700.0 9176.5 10688.4 11110.1 12311.1 13587.5 8868.9 11562.0 11198.4 4259.66 9129.0 True False 9390.294595639289 9436.997159097644 9601.40944341092 10161.197492968458 12358.513024067963 8779.686918316904 10689.869031380398 10901.38205447032 7228.331906742905 10300.796073990197 0.9116086298757092 0.9161425089199008 0.9321036330050986 0.9864477871400416 1.199762905245116 0.8523309126064404 1.0377711542482257 1.0583048121879257 0.7017255612888647 1.0 13.33046821672662 -5.685635348160106 4.552036037634342 0.9856808213335934 0.9168984151484195 0.0398931253274335 0.12349156089972635 0.700893493231517 26.980739978110627 0.03375360505971342 0.05936689921438499 2.0623608310402004e-06 5.685635348160106 -0.06878240618517384 AQS(ph)SPAAPASLSAPEPASQAR ddPTM_A459_Selumetinib_30min_R2 1 AQSSPAAPASLSAPEPASQAR 21 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10;H0YI15 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 AQS(0.896)S(0.104)PAAPASLSAPEPASQAR 271.42 4.9390999999999994e-60 53602000.0 17236.0 14985.0 16239.0 19152.0 20289.0 12632.0 16529.0 16235.0 11495.0 16439.0 True False 16278.092121174815 16134.30131563069 15194.200419686349 16543.46456095722 17740.114434038667 14371.943338121038 17297.631251592138 16282.241162151066 13794.321197135421 15964.363356348538 1.0196518181040721 1.0106448315845036 0.95175736611157 1.0362746193933499 1.1112321887226382 0.9002515801800363 1.083515256166692 1.0199117120242767 0.8640696086167347 1.0 13.962567400296313 -8.225331029865478 24.197195346078335 0.93203477231262 1.0164464829405018 0.21900146534736809 0.0639187939541917 503.48532586215777 337400.3382427593 0.0413423996977542 0.015624481464839439 5.952082882808044e-09 8.225331029865478 0.08441171062788178 AQS(ph)SPASATFPVSVQEPPTKPR ddPTM_A459_Selumetinib_30min_R1 2 AQSSPASATFPVSVQEPPTKPR 22 1 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 AQS(0.443)S(0.151)PAS(0.365)AT(0.042)FPVSVQEPPTKPR;AQS(0.761)S(0.216)PAS(0.008)AT(0.015)FPVSVQEPPTKPR 110.12 2.7086e-05 277000000.0 4410.1 4817.8 4890.9 5419.0 5487.2 4176.6 4868.5 5151.8 2789.19 4387.700000000001 True False 4512.846749439198 4253.729736265544 4226.742643790645 4472.673377228364 4990.8837288438435 4134.587196049386 4501.265125348162 5015.157528595176 4733.051715622433 4950.904034817264 0.9115197381533907 0.8591824253411422 0.8537314829909953 0.9034053873341638 1.008075231057888 0.8351176203321404 0.9091804433479191 1.0129781335542052 0.955997466793381 1.0 12.273476269947816 -7.684406825741803 6.115468355335539 0.9880096280152358 0.8953988840423516 0.45537857531639814 0.04644951176249361 0.1933925044447474 11.786758881273617 0.02312308017081453 0.013057029560694855 2.068203050036475e-08 7.684406825741803 -0.09261074397288427 AQS(ph)SPASATFPVSVQEPPTKPR ddPTM_A459_Selumetinib_30min_R2 4 AQSSPASATFPVSVQEPPTKPR 22 1 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 AQS(0.74)S(0.245)PAS(0.015)ATFPVSVQEPPTKPR;AQS(0.762)S(0.219)PAS(0.018)ATFPVSVQEPPTKPR;AQS(0.722)S(0.208)PAS(0.064)AT(0.006)FPVSVQEPPTKPR;AQS(0.795)S(0.202)PAS(0.002)ATFPVSVQEPPTKPR 174.61 5.6395e-13 257664000.0 253334.0 220151.0 293028.0 272449.0 282240.0 187486.0 211065.0 244190.0 220989.0 255881.0 True False 239254.71045635312 237035.87380296367 274174.8975047635 235340.97619926045 246782.48794238587 213310.49467154534 220879.94071736306 244900.5524721693 265192.9749485656 248493.05067131986 0.9628225409523173 0.953893371112778 1.1033503623705472 0.9470726668752778 0.9931162552662427 0.8584163383856145 0.8888777377099351 0.9855428625088501 1.0672047939857063 1.0 17.922845980541425 -8.009710188273642 24.303615308859765 1.0311929005161675 0.9590327669822345 0.18432445597795244 0.06283973236350747 578.1193396972182 1446962.6520409358 0.040368324968329074 0.017572427996747728 9.778895647819552e-09 8.009710188273642 -0.07216013353393302 AQS(ph)TDSLGTSGSLQSK ddPTM_A459_Selumetinib_30min_R1 1 AQSTDSLGTSGSLQSK 16 0 Q15276-2;Q15276;I3L456 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 1 AQS(0.493)T(0.493)DS(0.014)LGTSGSLQSK 214.63 1.0874e-08 20924000.0 4201.8 3404.8 4041.1 3582.0 4120.0 3063.5 3906.8 3414.5 1707.0 3464.7 True False 4299.693764720442 3006.164433151423 3492.340816173377 2956.4709424676143 3747.3467274450777 3032.6839714354487 3612.106930617276 3323.936368140888 2896.6543256527843 3909.4279940359147 1.0998268215401086 0.7689525009125431 0.8933124798566872 0.7562413086973087 0.9585409254657964 0.7757359838989244 0.9239476813814652 0.8502359867509436 0.7409407028526469 1.0 11.932741820446283 -4.749978896503052 24.975964270456274 0.8488042859530224 1.099827379349954 0.42571672256165904 0.08628418015669642 456.1726789938688 994079.0782345845 0.01952385961641843 0.30122387833968967 1.7783658233540135e-05 4.749978896503052 0.25102309339693163 AQS(ph)YDIQAWK ddPTM_A459_Selumetinib_30min_R1 1 AQSYDIQAWK 10 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 AQS(1)YDIQAWK 89.62899999999998 0.034766000000000005 0.0 1608.0 1759.7 2067.9 2030.2 1895.5 1685.1 1981.5 1650.7 985.14 1360.0 True False 1645.463271376665 1553.6735059376645 1787.0905381616205 1675.6636815739107 1724.0523596777052 1668.1494239483823 1832.0338596851986 1606.918073770731 1671.7106282211985 1534.5692475218184 1.072263942493263 1.0124492644738565 1.1645551616830585 1.0919439994512767 1.1234764168915048 1.0870473435084687 1.1938424171107018 1.0471460159688128 1.089367997515166 1.0 10.583618033628571 -8.817968133165449 1.3985735149373566 1.0006158236132967 1.10226058609623 0.26208981620781124 0.04987358788553169 1.4673098120405312 4.7914427608960715 0.047634130549507304 0.014038691492029663 1.5206591056708059e-09 8.817968133165449 0.1016447624829333 AQS(ph)YPDNHQEFSDYDNPIFEK ddPTM_A459_Selumetinib_30min_R1 4 AQSYPDNHQEFSDYDNPIFEK 21 0 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 AQS(0.961)Y(0.039)PDNHQEFSDYDNPIFEK;AQS(0.969)Y(0.031)PDNHQEFSDYDNPIFEK;AQS(0.996)Y(0.004)PDNHQEFSDYDNPIFEK;AQS(0.528)Y(0.024)PDNHQEFS(0.443)DY(0.005)DNPIFEK 126.16 4.4037e-05 107891700.0 12461.2 13138.099999999999 15504.2 15940.2 14572.0 11839.800000000001 14417.1 13264.7 7674.8 11078.9 True False 12751.521714725686 11599.885144263015 13398.81479847449 13156.54330461258 13253.965172895558 11720.702361678274 13329.606539726203 12912.877066182 13023.575054786166 12500.98473262461 1.0200413797360486 0.9279177114735658 1.0718207473293488 1.0524405545650428 1.0602336900952967 0.93758232750177 1.0662845227655615 1.032948791024634 1.0418039325172295 1.0 13.609754123470244 -5.265999342605631 24.998750149587764 1.033529770075684 0.9739795463440765 0.23314962550148233 0.042722516872521474 482.18951558581807 2643489.0900313403 0.010931171520050421 0.024031874855401477 5.420017108325019e-06 5.265999342605631 -0.059550223731607566 AQS(ph)YPDNHQEFSDYDNPIFEK ddPTM_A459_Selumetinib_30min_R2 4 AQSYPDNHQEFSDYDNPIFEK 21 0 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 AQS(0.516)Y(0.448)PDNHQEFS(0.036)DYDNPIFEK;AQS(0.975)Y(0.025)PDNHQEFSDYDNPIFEK;AQS(0.94)Y(0.06)PDNHQEFSDYDNPIFEK;AQS(0.666)Y(0.334)PDNHQEFSDYDNPIFEK 118.9 4.9552e-05 41062300.0 215612.0 183136.0 234422.0 244351.0 241000.0 168186.0 166464.0 188108.0 164504.0 194160.0 True False 203629.14820322243 197181.94232494803 219339.5437393747 211069.972271014 210723.42543266382 191352.0948595014 174204.90584215822 188655.3631370441 197409.39662579994 188554.0963117364 1.079950805558541 1.0457579346297905 1.163271167425293 1.1194133482099065 1.117575430895306 1.0148392350126358 0.923898813389582 1.0005370704073184 1.0469642425557444 1.0 17.52461896760763 -6.840182804113646 4.8379540877894955 0.9902038207195782 1.1058984674981482 0.6487406226993223 0.03984970869633889 0.1368404865554957 5.773468636345168 0.01511355953172722 0.013431043825769757 1.4448314813378763e-07 6.840182804113646 0.11569464677857 AQSEGRPCEYNSR ddPTM_A459_Selumetinib_30min_R1 1 AQSEGRPCEYNSR 13 1 O00622 O00622 CYR61 Protein CYR61 0 101.72 0.027861 1371700.0 401.69 640.67 493.71 398.92 513.37 526.93 345.99 340.16 500.83 201.57 False True 411.0485954473215 565.6600585605975 426.66689375490785 329.25611065582916 466.93577414283527 521.6295626141605 319.89169574185297 331.13785180459934 849.8719308240682 227.44347295806824 1.8072560627980865 2.487035794889059 1.8759249856933404 1.4476393029600425 2.052975045051832 2.2934470522718793 1.406466809451281 1.4559127483321903 3.736629237018165 1.0 7.829364223366084 AQSGSDS(ph)SPEPK ddPTM_A459_Selumetinib_30min_R1 5 AQSGSDSSPEPK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQSGS(0.057)DS(0.714)S(0.229)PEPK;AQSGS(0.004)DS(0.498)S(0.498)PEPK;AQSGSDS(0.936)S(0.064)PEPK;AQSGS(0.003)DS(0.499)S(0.499)PEPK;AQSGS(0.004)DS(0.498)S(0.498)PEPK 201.3 8.1357e-05 41430400.0 19105.4 26228.0 27389.699999999997 22883.9 20548.0 25000.3 19709.0 23403.100000000002 22112.699999999997 21017.2 True False 19550.51864736304 23157.213566933602 23670.329180852736 18887.65644900463 18689.437028044053 24748.819680456207 18222.33426219307 22782.373764017564 37523.63685229192 23714.962344864372 0.8243959388616456 0.9764811442742368 0.9981179323263272 0.7964447159704166 0.7880863041762902 1.0435951497859208 0.7683897615860746 0.9606750975487521 1.5822768894430863 1.0 14.533509957225984 -8.079646906121026 8.466177075978983 1.2884217686329438 0.8899439523047021 0.5058094114383302 0.15829419073242537 0.2648569075300097 25.932436623254493 0.09898267974999755 0.037280560484187576 8.324402939009495e-09 8.079646906121026 -0.39847781632824164 AQSGSDS(ph)SPEPK ddPTM_A459_Selumetinib_30min_R2 2 AQSGSDSSPEPK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQSGS(0.014)DS(0.698)S(0.288)PEPK;AQSGS(0.009)DS(0.495)S(0.495)PEPK 157.09 0.00044141 14376400.0 51595.0 42895.0 43850.0 47356.0 47810.0 44091.0 73018.0 121189.0 44669.0 82022.0 True False 48727.55645114958 46184.90857083605 41028.73874027011 40906.031106343464 41803.68037317703 50164.13503175226 76413.48168242212 121541.63992608096 53604.048156141165 79653.81174125052 0.6117416779681232 0.5798204450135329 0.5150882028539816 0.5135476910913399 0.5248170735252843 0.6297769552410966 0.9593198368289722 1.5258734926697535 0.6729627494823465 1.0 16.28145578145846 -7.29071810639958 3.488982510647501 1.0992293269255105 0.5513958099774536 0.5861222857316087 0.19707969651298826 0.15244544684552047 3.922199911542528 0.08157846431931554 0.05518837184299953 5.120140678456143e-08 7.29071810639958 -0.5478335169480568 AQSGSDSS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 1 AQSGSDSSPEPK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQS(0.002)GS(0.097)DS(0.213)S(0.688)PEPK 89.13600000000002 0.026192 3397100.0 1421.9 1604.1 2158.4 2189.9 1410.8 1652.6 1721.0 1719.8 1014.9 1443.6 True False 1455.0275034642289 1416.2912262741418 1865.3011352425372 1807.4750745141882 1283.1933890969697 1635.9763444407447 1591.1835844149518 1674.1853173022976 1722.2111746367955 1628.900121854776 0.8932576552375943 0.8694770215017583 1.1451292256756533 1.109629160353966 0.7877667708906786 1.0043441721754622 0.9768453959001012 1.0278010878874249 1.0572846987547457 1.0 10.669682430500739 -7.754803557510397 3.8442349133377234 1.0335096999338342 0.9715028972572167 0.0660112535974422 0.1011356411152462 0.7293089143015764 23.477700903544495 0.059852070437217075 0.029462259151940128 1.7587189475823525e-08 7.754803557510397 -0.06200680267661751 AQSGSDSS(ph)PEPK ddPTM_A459_Selumetinib_30min_R2 1 AQSGSDSSPEPK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQSGS(0.009)DS(0.3)S(0.691)PEPK 127.3 0.0026128 2229600.0 14700.0 12390.0 12475.0 13629.0 13056.0 11765.0 13781.0 17673.0 11732.0 16972.0 True False 13883.03284876245 13340.27315987082 11672.37208175302 11772.70668866363 11415.788557879085 13385.521957963425 14421.843806533441 17724.425504077353 14078.727819468711 16481.97426144822 0.8423161344958071 0.8093856323434552 0.7081901656074667 0.7142777013188466 0.6926226419720191 0.8121309829534511 0.8750070578781646 1.0753824282771307 0.8541894069328353 1.0 14.008601442859868 -7.346992987342919 2.5163835018188414 0.9732497595664238 0.7536144878884005 0.6583953306651 0.0689138450470209 0.17684860636294492 2.1876002414506126 0.03384699977475542 0.02108992511992273 4.497871176550347e-08 7.346992987342919 -0.21963527167802332 AQSLAEQT(ph)SDTAGLESSTR ddPTM_A459_Selumetinib_30min_R2 1 AQSLAEQTSDTAGLESSTR 19 0 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 AQS(0.007)LAEQT(0.689)S(0.185)DT(0.119)AGLESSTR 212.34 2.2611e-16 2996500.0 7891.6 5904.7 6806.3 7298.7 7320.8 3655.4 7721.9 8958.0 3609.8 4050.6 True False 7453.016464577806 6357.571503397032 6368.390068139124 6304.604469040224 6401.095655217618 4158.898169582615 8080.983650654565 8984.066296923267 4331.860866239186 3933.6486532772906 1.8946828050767524 1.6162021735470116 1.6189524356308098 1.602737057817197 1.627266748870566 1.0572622356899262 2.05432268179873 2.283901560307949 1.1012322777302768 1.0 11.941652388996651 -4.75741380969918 4.558634109630803 1.596262284653207 1.9202878630443534 0.05308865625850734 0.3969002258866828 0.7789529655602649 36.18666788151838 0.09814900895551022 0.8332245004259552 1.7481801727074466e-05 4.75741380969918 0.3240255783911463 AQSLVIS(ph)PPAPSPR ddPTM_A459_Selumetinib_30min_R2 1 AQSLVISPPAPSPR 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AQSLVIS(0.938)PPAPS(0.062)PR 99.915 0.0093583 7275000.0 14823.0 21390.0 20070.0 16058.0 18737.0 13523.0 12344.0 11997.0 11007.0 18705.0 True False 13999.197001170465 23030.54422030967 18778.718050563763 13870.872698404919 16383.090549094712 15385.670500428345 12918.020459171961 12031.90928378973 13208.70756127618 18164.93804857348 0.7706713319768158 1.2678570198657129 1.03378927031565 0.7636069366883539 0.9019073175634255 0.8469982368938828 0.7111513633918742 0.6623699597332022 0.7271540109829044 1.0 14.148868825007321 -5.748914819718189 11.353212290313044 0.7900679882101111 1.0486479140401341 0.3219376090499586 0.14579334619063394 0.39049893837584165 341.8662993030058 0.03921583345200059 0.06561654057108894 1.7827283883204397e-06 5.748914819718189 0.258579925830023 AQSLVISPPAPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 AQSLVISPPAPSPR 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AQSLVISPPAPS(1)PR;AQSLVISPPAPS(1)PR 195.45 0.00012484 105262000.0 2662.4 7664.4 4024.0 5090.4 4226.5 3496.7000000000003 4223.6 2756.0 1591.03 3203.4 True False 2724.428739871413 6767.048484917104 3477.5629022498 4201.457198642414 3844.2138212491827 3461.526372749578 3905.0104515601297 2682.90192725034 2699.8617057664605 3614.587593758377 0.7537315583597757 1.8721495355659263 0.9620911963109735 1.1623614284233799 1.0635276422370623 0.9576545824278535 1.0803474394432304 0.7422428859887475 0.7469349229296717 1.0 11.819615336989175 -6.57892025772732 0.773452818381249 0.8420549375517113 1.2730720559698279 0.18845867745389533 0.28204496153546316 0.9597583266692831 1.276693473131228 0.1736251967320875 0.20623316359393756 2.6368154959544177e-07 6.57892025772732 0.4310171184181165 AQSLVISPPAPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AQSLVISPPAPSPR 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 AQSLVISPPAPS(1)PR 168.16 0.00020115 49150000.0 100420.0 111500.0 96416.0 72082.0 82812.0 49838.0 79932.0 64849.0 65865.0 105160.0 True False 94839.05841311067 120051.69147099229 90212.69952980336 62264.30725161437 72408.4162113269 56702.7321156805 83648.99638225314 65037.69985367012 79039.84042186373 102123.75756150715 0.9286679287725087 1.1755510601799732 0.8833664338630509 0.6096946365698872 0.7090261653143415 0.5552354659642204 0.8190943848876004 0.6368518100648537 0.7739613417011176 1.0 16.639959001074544 -5.527765946810508 5.239634093477827 0.7108134873340861 1.0497921039345037 0.4933701672990013 0.13042658484511965 0.11568959590985002 9.87799287186092 0.03274391309508973 0.062212997473605376 2.9664296489865516e-06 5.527765946810508 0.3389786166004176 AQSNGSGNGS(ph)DSEMDTSSLER ddPTM_A459_Selumetinib_30min_R1 1 AQSNGSGNGSDSEMDTSSLER 21 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 AQSNGSGNGS(1)DSEMDTSSLER 361.7 5.549799999999993e-218 14542000.0 1169.0 1001.6 852.03 1279.0 1270.0 887.79 1164.5 883.48 431.29 957.94 True False 1196.235425521966 884.332206368793 736.3290058657795 1055.6466598034833 1155.1287242367118 878.8596386488255 1076.6608274556716 860.0472404525142 731.8676298247158 1080.9009301257727 1.1067021890551736 0.8181436260452591 0.6812178483185327 0.976635906567912 1.0686721530550465 0.8130806572130178 0.9960772513447577 0.7956762886238241 0.6770903876820203 1.0 10.078018583714245 -7.791691066826485 24.338698659025415 0.8022873021081856 0.9130515166649598 0.08381894672370982 0.14149609337208857 372.583793635638 299752.25345146656 0.077694504736323 0.03733184786397912 1.615507331123991e-08 7.791691066826485 0.11076421455677421 AQSNGSGNGS(ph)DSEMDTSSLER ddPTM_A459_Selumetinib_30min_R2 4 AQSNGSGNGSDSEMDTSSLER 21 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 AQSNGSGNGS(1)DSEMDTSSLER;AQSNGSGNGS(0.974)DS(0.026)EMDTSSLER;AQSNGSGNGS(0.995)DS(0.005)EMDTSSLER;AQS(0.001)NGS(0.072)GNGS(0.925)DS(0.001)EMDTSSLER 316.27 6.568399999999995e-119 75499300.0 128202.0 113829.0 128822.0 144535.0 141526.0 111588.0 115247.0 115029.0 97192.0 117570.0 True False 121077.04607326842 122559.31828207686 120533.73277078835 124849.083663218 123746.23862150697 126958.23410499116 120606.21385759822 115363.71534592385 116633.11577137776 114175.44861645454 1.06044729878836 1.073429706361706 1.0556887161940827 1.093484502807771 1.0838252892458802 1.1119573922715853 1.0563235381955567 1.0104073751745088 1.021525355798506 1.0 16.80089293277986 -7.639538890747776 3.800429950197614 1.0117683898813545 1.079579240701996 0.7898252890331535 0.015902602161133247 0.1073406228174479 2.906881232802 0.008640580361589231 0.0046509246494258055 2.2933012578306297e-08 7.639538890747776 0.06781085082064142 AQSNGSGNGSDS(ph)EMDTSSLER ddPTM_A459_Selumetinib_30min_R1 1 AQSNGSGNGSDSEMDTSSLER 21 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 AQSNGSGNGS(0.248)DS(0.752)EMDTSSLER 244.72 1.1594e-31 11830000.0 1413.1 1797.8 1823.3 1776.2 1610.6 1382.1 1796.3 1603.1 878.0 1401.4 True False 1446.0224805860491 1587.3127402254552 1575.7058746699956 1466.0200134033996 1464.9215143745257 1368.1973288463944 1660.8036447905733 1560.580580397322 1489.901873417191 1581.2833407919663 0.9144613386376578 1.0038129785332899 0.9964728230683962 0.9271077330576072 0.9264130447620081 0.8652448891045356 1.0502884599788298 0.9869076212588974 0.942210567190945 1.0 10.626880183497104 -7.277370201522451 24.998116538731683 0.9937606204471775 0.9433793119311645 0.27060391906126524 0.04461357176007273 1378.3523225652254 2162854.8768139468 0.01985197578819264 0.013435672527412186 5.2799498614083576e-08 7.277370201522451 -0.05038130851601297 AQSPS(ph)YVISTGVSPSR ddPTM_A459_Selumetinib_30min_R1 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQS(0.277)PS(0.722)YVISTGVS(0.001)PSR 123.63 0.001351 5582200.0 1753.1 1808.4 1966.1 2391.9 2362.5 1695.5 2087.4 1757.2 852.24 1780.6 True False 1793.9438190612143 1596.6716872976488 1699.1144190142486 1974.1995665238082 2148.812292133252 1678.4448093908265 1929.9457374246197 1710.5933478099782 1446.1890348531517 2009.1573545127567 0.8928836833172114 0.7946971817370968 0.8456850904175711 0.9826007714575317 1.0695092085778235 0.8353973896673057 0.9605747071476406 0.8513983954356907 0.7197987910727226 1.0 10.972374843101258 -14.522734767067695 0.005537229074759455 1.8527247308831962 0.025988367984211246 0.02246497851586393 0.0999020799806064 330304.980464643 138.52965122102745 24844.145159322426 21006.45407772402 3.0009947311370036e-15 14.522734767067695 -1.826736362898985 AQSPS(ph)YVISTGVSPSR ddPTM_A459_Selumetinib_30min_R2 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQS(0.351)PS(0.646)Y(0.002)VIS(0.001)T(0.001)GVSPSR 108.96 0.003961 0.0 23801.0 25683.0 23797.0 28663.0 22163.0 14590.0 17963.0 17721.0 13369.0 22606.0 True False 22478.235702952057 27652.803516139 22265.92692821456 24759.04995356706 19378.685800266092 16599.640065166706 18798.31509300923 17772.56517613053 16043.173561070333 21953.30604255826 1.0239111894753428 1.259619096209555 1.0142402645437667 1.1278050743505166 0.8827228920645912 0.7561339523526417 0.8562862949465186 0.8095621288965305 0.730786220989647 1.0 14.422150597307697 -6.3431479759428 3.7679943085693646 0.8200852279182308 1.1121463344389346 0.6664546353947114 0.09278126313504662 0.12998129611109333 3.5082296664924844 0.02800651099269106 0.03252050757500962 4.537869727413813e-07 6.3431479759428 0.29206110652070383 AQSPSYVISTGVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQSPSYVISTGVS(0.874)PS(0.126)R 166.3 1.6665e-05 8108100.0 1195.7 1264.7 1225.4 1405.9 1402.8 1223.1 1422.5 1347.5 778.43 1076.1 True False 1223.5574835728112 1116.6283360569214 1058.997410640384 1160.3859570115062 1275.9169876844553 1210.7967244859458 1315.199679738679 1311.7599227031321 1320.9388557222599 1214.2279171016387 1.0076835381066203 0.9196200485344733 0.8721570272969923 0.9556574516762444 1.050805182218235 0.9971741774609473 1.0831571743779864 1.0803242984515644 1.0878837795752054 1.0 10.245823533282188 -6.210300950872496 3.596007501688704 1.0539190385209452 0.929358308474631 0.6172536571431124 0.042957478291850315 0.15726241370113156 4.172293307881459 0.013756298902431713 0.01769335389206999 6.161678711209163e-07 6.210300950872496 -0.12456073004631418 AQSPSYVISTGVS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQSPSYVISTGVS(0.942)PS(0.058)R 183.39 8.723700000000002e-07 12954000.0 25785.0 16459.0 24173.0 29986.0 26383.0 15235.0 24570.0 22654.0 16593.0 19172.0 True False 24351.972925533322 17721.352375973674 22617.7354975724 25901.855071264774 23068.531672987425 17333.482960439684 25712.553684531355 22719.919389428404 19912.063647156876 18618.454545161752 1.3079481364290517 0.9518165072717487 1.2148019827698273 1.3911925400916645 1.239014313300353 0.9309839824994505 1.3810251340766142 1.2202902950036993 1.0694799398552275 1.0 14.184445704188095 AQSPSYVISTGVSPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQSPSYVISTGVS(0.396)PS(0.604)R 140.96 0.00039818 8925700.0 1505.8 1540.5 1767.1 1852.1 1810.2 1639.0 1907.3 1763.5 800.67 1485.5 True False 1540.8822102232486 1360.1375438409793 1527.1375259854929 1528.665503222855 1646.4677296167686 1622.5131480929317 1763.4308254239613 1716.7262513446938 1358.6785113769276 1676.1783949953387 0.919282944359591 0.8114515423310665 0.9110829315931731 0.9119945154925506 0.9822747593768784 0.9679835708044929 1.052054381973385 1.024190656836063 0.8105810905531364 1.0 10.710959987326284 -5.959271256748901 1.776293966265113 0.9784155708437557 0.8680911332402987 0.2886694773247892 0.06594204652205256 0.4255723119264237 2.716890981797525 0.021605990307114548 0.036865050990615426 1.0983196237805992e-06 5.959271256748901 -0.110324437603457 AQSPSYVISTGVSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 AQSPSYVISTGVSPSR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 AQSPSYVISTGVS(0.415)PS(0.585)R 193.71 1.1735e-06 13144000.0 26596.0 26019.0 22545.0 26505.0 31728.0 15204.0 21815.0 25476.0 20067.0 21837.0 True False 25117.900792223536 28014.573635728724 21094.479245140028 22894.97327632472 27742.04498808118 17298.212991829652 22829.440725602442 25550.130942221163 24080.960718827013 21206.50907066021 1.1844429796781049 1.3210365526161805 0.9947171962557865 1.0796200921159884 1.3081853734456967 0.8157029963862467 1.0765298828550525 1.2048249363951409 1.1355457250690868 1.0 14.372219529368634 -5.257240823054593 24.780292309823018 1.0832229244870866 1.2527397672629914 0.230776723403063 0.12800224847082078 476.81790781255177 2814195.1758450363 0.033038953307407214 0.08106239919454093 5.530433530198462e-06 5.257240823054593 0.16951684277590484 AQSS(ph)PAAPASLSAPEPASQAR ddPTM_A459_Selumetinib_30min_R2 2 AQSSPAAPASLSAPEPASQAR 21 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10;H0YI15 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 AQS(0.235)S(0.765)PAAPASLSAPEPASQAR;AQS(0.127)S(0.867)PAAPAS(0.006)LSAPEPASQAR 191.71 1.3136e-16 58043700.0 24395.6 20906.3 26839.0 35743.0 32266.0 19790.9 23805.7 21319.7 19266.7 24231.0 True False 23039.79021532443 22509.745985650294 25112.20796009373 30874.74173988582 28212.45661830015 22516.91683109719 24912.71222009965 21381.73679733366 23120.578356576705 23531.38807030119 0.9791088458739413 0.9565838580538177 1.0671792027342273 1.3120663195747737 1.1989287046736912 0.9568885933896796 1.0587013458650074 0.9086474938688129 0.9825420535117958 1.0 14.522298804364748 -6.784129495972173 24.997075294173044 0.9804804201737949 1.1043017016630823 0.2630438024292302 0.10159362679549758 381.7791011107481 420592.6352905009 0.0407049641972738 0.035923108040541434 1.6438814849543382e-07 6.784129495972173 0.1238212814892874 AQSTDS(ph)LGTSGSLQSK ddPTM_A459_Selumetinib_30min_R2 3 AQSTDSLGTSGSLQSK 16 0 Q15276-2;Q15276;I3L456 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 1 AQSTDS(0.915)LGT(0.082)S(0.002)GSLQSK;AQSTDS(0.391)LGT(0.212)S(0.39)GS(0.006)LQS(0.001)K;AQS(0.002)T(0.005)DS(0.969)LGT(0.008)S(0.014)GS(0.002)LQSK 278.88 1.7478999999999993e-62 39952000.0 115322.0 84816.0 98819.0 117355.0 108539.0 89327.0 100425.0 95667.0 65804.0 90399.0 True False 108912.86491054317 91321.11447357568 92461.093125992 101371.04655133322 94903.36046902864 101630.98342022933 105094.96148836242 95945.37513147567 78966.63871738159 87788.94598519073 1.2406216259723162 1.040234774990701 1.0532202213885724 1.154713106686959 1.0810399806490223 1.157674036061142 1.197132056991447 1.092909523571007 0.8995054882046608 1.0 16.421751672654835 -8.148170762831368 5.235412308542287 0.9520615568149906 1.1264843503190307 0.5613610394146522 0.06325169293383193 0.16184424489188914 6.194863210812177 0.0448410973042566 0.016172555119078842 7.109339223508998e-09 8.148170762831368 0.1744227935040401 AQSTDSLGT(ph)SGSLQSK ddPTM_A459_Selumetinib_30min_R2 1 AQSTDSLGTSGSLQSK 16 0 Q15276-2;Q15276;I3L456 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 1 AQS(0.045)T(0.023)DS(0.351)LGT(0.434)S(0.139)GS(0.009)LQSK 120.99 0.0036487 13414000.0 48178.0 32736.0 48274.0 42470.0 49200.0 35026.0 35393.0 34974.0 24330.0 35397.0 True False 45500.45963181482 35246.745937169595 45168.103396757106 36685.51273516356 43019.05614641937 39850.513565629124 37038.84462989903 35075.768549742614 29196.679836999116 34374.996637549084 1.3236498642188368 1.0253599821059551 1.3139813182532303 1.0672150203235398 1.2514635739463043 1.1592877807615238 1.0774937673576417 1.020386093985186 0.8493580419759663 1.0 15.069071951954356 -7.658506247563459 1.6735169882009224 0.9291292622506102 1.1867592265109492 0.546304842457414 0.09709630707156225 0.27697488839671724 1.4995995176785917 0.06386394657612422 0.027594625772094105 2.1952993683315798e-08 7.658506247563459 0.257629964260339 AQT(ph)LPTSVVTITSESSPGK ddPTM_A459_Selumetinib_30min_R1 2 AQTLPTSVVTITSESSPGK 19 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(1)LPTSVVTITSESSPGK;AQT(0.999)LPT(0.001)SVVTITSESSPGK 253.52 1.2e-37 82625000.0 13225.8 15833.9 8648.4 9920.1 9290.5 11624.6 11564.099999999999 10577.0 7069.6 10362.8 True False 13533.935407073073 13980.059627019593 7473.994782260726 8187.74075833975 8450.175915370999 11507.667078292316 10691.810626689678 10296.463601061994 11996.594856845306 11692.96632221992 1.157442434547579 1.1955956462863964 0.6391872324183503 0.7002278577319377 0.722671705580242 0.9841529310167016 0.9143796648393859 0.8805689948405839 1.0259667672221382 1.0 13.513353344961331 -5.237786309436233 24.761790765959752 0.8501238065622199 1.1765191624294764 0.5016162242527944 0.1266246756868728 593.0595982338979 620856.3381853742 0.03462276461681884 0.09148589266552373 5.783805641845697e-06 5.237786309436233 0.32639535586725654 AQT(ph)LPTSVVTITSESSPGK ddPTM_A459_Selumetinib_30min_R2 3 AQTLPTSVVTITSESSPGK 19 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(0.996)LPT(0.003)S(0.001)VVTITSESSPGK;AQT(0.996)LPT(0.003)S(0.001)VVTITSESSPGK;AQT(0.981)LPT(0.018)S(0.001)VVTITSESSPGK 269.39 2.9587e-58 28230600.0 220817.0 166566.0 181743.0 206599.0 191391.0 197017.0 185137.0 189301.0 174341.0 175662.0 True False 208544.87514048826 179341.07660589507 170049.85324681632 178459.8597968463 167346.75152275106 224154.30340774145 193746.23734200577 189851.83456953222 209214.07149454486 170590.18163531212 1.2224904923679354 1.051297764541283 0.9968325938614045 1.0461320697715064 0.9809870059257286 1.3139929933771848 1.1357408467750898 1.112911849612762 1.2264133227890157 1.0 17.380175088773733 -6.730938157456615 24.999959845942545 1.1634896698943396 1.0548601584732953 0.20304910989738167 0.0967889294963073 304.91668119230775 249920.59850678896 0.03127231084019237 0.03126889186413233 1.8580690210438903e-07 6.730938157456615 -0.10862951142104427 AQT(ph)LPTSVVTITSESSPGKR ddPTM_A459_Selumetinib_30min_R1 1 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(0.953)LPT(0.044)S(0.004)VVTITSESSPGKR 152.34 1.128e-05 444780000.0 2603.1 2545.7 2992.0 3006.5 2542.5 2809.2 2074.3 2414.7 1651.0 1896.6 True False 2663.747165249127 2247.6482605361784 2585.7028338795753 2481.471213994663 2312.5313239148322 2780.941998549521 1917.8338809714899 2350.654311948984 2801.6264157309597 2140.0470844484403 1.244714279702711 1.0502798171449907 1.2082457683616783 1.1595404755471623 1.080598338569194 1.299477015603262 0.8961643390504084 1.0984124270120084 1.309142418449653 1.0 11.063426823229161 -10.198237898155282 13.921882882467774 0.9999999999035654 1.142130671165056 0.12115764240575033 0.11936583627249937 0.0 0.0 0.11146597105353229 0.027034468959750257 6.335225847169228e-11 10.198237898155282 0.1421306712614907 AQT(ph)PENKPGHMEQDEDSCTAQPELAK ddPTM_A459_Selumetinib_30min_R2 1 AQTPENKPGHMEQDEDSCTAQPELAK 26 1 F5H527;Q76I76;A0A3B3IS79 F5H527 SSH2 Protein phosphatase Slingshot homolog 2 1 AQT(0.977)PENKPGHMEQDEDS(0.019)CT(0.004)AQPELAK 47.554 0.027455 6266600.0 30369.0 32034.0 32492.0 33931.0 26873.0 22313.0 25301.0 25964.0 17958.0 22050.0 True False 28681.212556739254 34490.90479445535 30401.500094614756 29309.53926576018 23496.973492331847 25386.41321275291 26477.546632980386 26039.55094142841 21550.101788443506 21413.359207219735 1.3394074362264976 1.6107190124016781 1.419744552940791 1.3687501798353137 1.0973044100623688 1.185540903091637 1.2364966363639576 1.2160423168285015 1.0063858537981125 1.0 14.386223514901378 -6.107188856319477 0.4188851594478001 1.0405549716541125 1.5993339455155675 0.6835160696086247 0.10244975436048046 1.185186612302442 0.348276919926654 0.09966367890868422 0.2980125200480709 7.812879815757471e-07 6.107188856319477 0.558778973861455 AQT(ph)PHEDGGPQPHR ddPTM_A459_Selumetinib_30min_R2 1 AQTPHEDGGPQPHR 14 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 AQT(1)PHEDGGPQPHR 112.02 0.005077600000000001 9456100.0 10218.0 9910.6 12087.0 8937.4 13857.0 15287.0 14246.0 13724.0 11067.0 14100.0 True False 9650.124465894882 10670.71115239836 11309.335579330562 7720.110702125055 12116.159776848232 17392.645488430662 14908.467227913467 13763.934567869499 13280.709237816256 13692.896363800384 0.7047540717102562 0.7792880971923727 0.8259272018759164 0.5638040701552773 0.8848500313549048 1.2701947802958053 1.0887738307380066 1.0051879603979854 0.9698977400373949 1.0 13.741140021742652 -6.525963375173578 24.513833698535137 1.069509477949036 0.7296993424511137 0.7307762683667218 0.09969923909947974 39.21516957360597 311640.3523631474 0.03339437903337723 0.033575142520827224 2.9787676236111897e-07 6.525963375173578 -0.33981013549792227 AQT(ph)PPGPSLS(ph)GSKSPCPQEK ddPTM_A459_Selumetinib_30min_R1 1 AQTPPGPSLSGSKSPCPQEK 20 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AQT(0.895)PPGPS(0.199)LS(0.64)GS(0.168)KS(0.099)PCPQEK 68.074 0.046313 76194000.0 7254.4 7148.0 8193.5 8086.1 6489.4 6869.7 6417.8 6222.5 4011.1 5684.6 True False 7423.413405394824 6311.108836984955 7080.86770367389 6674.014429895971 5902.434915796627 6800.597055188537 5933.700178999579 6057.4590864714255 6806.5437408470325 6414.273782693031 1.1573271826071176 0.9839163482565345 1.1039235217522927 1.040494162862797 0.9202031462583582 1.0602286845843534 0.9250774725285139 0.9443717701629198 1.06115578652293 1.0 12.647070218813296 -6.011815980129741 22.196025631986906 0.9828856976009418 1.0719863088430337 0.3357417440257634 0.061003793160070915 149.57741895497983 280982.0039631624 0.016761911496013436 0.022954990173702852 9.731594849380401e-07 6.011815980129741 0.0891006112420919 AQT(ph)PPGPSLS(ph)GSKSPCPQEK ddPTM_A459_Selumetinib_30min_R2 1 AQTPPGPSLSGSKSPCPQEK 20 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 AQT(0.997)PPGPS(0.043)LS(0.457)GS(0.282)KS(0.221)PCPQEK 73.109 0.02627 472840000.0 180360.0 174420.0 162520.0 183130.0 180640.0 145120.0 146570.0 153170.0 122280.0 150330.0 True False 170336.3132382853 187797.45315130474 152063.64013839647 158187.37808312924 157946.38825791056 165108.96273180208 153385.7954229451 153615.69934134147 146739.41678866633 145989.5822957524 1.1667703308665558 1.286375713924957 1.0416061046762841 1.0835525083061475 1.0819017752782902 1.130964005344688 1.0506626090086972 1.05223740574954 1.0051362191816873 1.0 17.155505897607227 -1.5228787452821122 0.2307546661727809 1.0032388369742657 2.2556634833476914 0.5563641050971524 0.0544621718943067 37.71740804573735 0.49449822332989557 0.0796824995848336 17.86033810584529 0.029999999999877413 1.5228787452821122 1.2524246463734257 AQT(ph)PPGPSLSGSK ddPTM_A459_Selumetinib_30min_R1 4 AQTPPGPSLSGSK 13 0 Q9UQ35;Q9UQ35-2;I3L4D8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQT(0.843)PPGPS(0.144)LS(0.004)GS(0.009)K;AQT(0.994)PPGPS(0.005)LSGSK;AQT(0.995)PPGPS(0.005)LSGSK;AQT(0.969)PPGPS(0.023)LS(0.007)GSK 122.93 0.0059671 235757000.0 28526.5 30416.6 24016.5 23306.1 25240.2 21365.7 27197.3 25688.3 13861.3 23736.600000000002 True False 29191.111947093556 26855.4103317063 20755.191213191436 19236.127144680187 22957.228366519255 21150.780456503468 25145.785764328146 25006.962836641826 23521.613710703536 26783.423824063517 1.0898947102075447 1.0026877261143181 0.7749267363847625 0.7182101612937748 0.857143153814912 0.7896966644533545 0.9388562840026435 0.9336731181535636 0.8782153418925696 1.0 14.709052777040068 -10.050587908342411 17.058772786533375 0.9999999836847221 0.8813267359104677 0.0914465374623753 0.10545020422359161 0.0 0.0 0.11105498640538851 0.02693479054123237 8.900452599834447e-11 10.050587908342411 -0.11867324777425436 AQT(ph)PPGPSLSGSK ddPTM_A459_Selumetinib_30min_R2 1 AQTPPGPSLSGSK 13 0 Q9UQ35;Q9UQ35-2;I3L4D8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQT(0.719)PPGPS(0.276)LS(0.004)GS(0.001)K 98.943 0.028403 273690000.0 47918.0 34344.0 42563.0 42785.0 46159.0 38127.0 40495.0 46373.0 43783.0 32038.0 True False 45254.909390952314 36978.07436663463 39824.54291909045 36957.60919175827 40360.093753304296 43378.64816755386 42378.09773932023 46507.93775253655 52540.82339923274 31112.979695279184 1.454534725834019 1.188509577957439 1.2799977150736572 1.1878518082717064 1.2972108151836126 1.394229951370931 1.362071333391135 1.4948082185645903 1.6887107539624315 1.0 14.925228948184138 -6.828195676400424 2.342678492636531 1.4256666668450824 1.2682774262420768 0.06695191745935025 0.17519825965226365 0.5959221026494234 6.6934113221996885 0.06663268918595056 0.05900491864704177 1.4852662876060657e-07 6.828195676400424 -0.15738924060300552 AQT(ph)PPISSLPTSPSDEVGR ddPTM_A459_Selumetinib_30min_R1 2 AQTPPISSLPTSPSDEVGR 19 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 AQT(1)PPISSLPTSPSDEVGR;AQT(0.983)PPIS(0.016)S(0.001)LPTSPSDEVGR 178.07 1.6574e-12 17448600.0 3216.8999999999996 3656.8 3049.4 3368.0 2759.8999999999996 2859.1000000000004 3156.3 2846.8 1748.68 2630.4 True False 3291.8475110022346 3228.6601559998 2635.3082291552037 2779.8420251900934 2510.26753229992 2830.3400498550945 2918.2177498482906 2771.293616290373 2967.382241466031 2968.0374622657255 1.109099043678957 1.0878097722981979 0.8878958782223306 0.9365926342007933 0.845766795134602 0.9536065787035194 0.9832145944750293 0.9337124788764751 0.9997792410614674 1.0 11.535293586285189 -5.221960267275401 9.181468461137564 0.9384001627803322 1.099028407384749 0.6465080957772107 0.04602507979497686 0.2749606385341996 61.06955955464387 0.011920758798935789 0.03140121511742915 5.998459524393348e-06 5.221960267275401 0.16062824460441671 AQT(ph)PPISSLPTSPSDEVGR ddPTM_A459_Selumetinib_30min_R2 1 AQTPPISSLPTSPSDEVGR 19 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 AQT(0.986)PPIS(0.012)S(0.003)LPTSPSDEVGR 139.2 0.00031788 8858200.0 18612.0 14781.0 17102.0 16563.0 17791.0 14420.0 17810.0 19438.0 15126.0 15318.0 True False 17577.619549739225 15914.655171594064 16001.675939249697 14307.090827231314 15555.93552644201 16406.22410827305 18638.200289845496 19494.561361865868 18151.622655752104 14875.729539056329 1.1816307565682118 1.0698403147092739 1.075690163446249 0.9617740622177857 1.0457258909957858 1.1028853452328773 1.2529268054323504 1.3104944742832791 1.2202173082062897 1.0 13.860672802697408 -7.124957577086844 4.270763412127319 1.2210411648329655 1.0627066721047775 0.2938054943890053 0.09108404672784592 0.24142096059087406 7.244220480784005 0.03549615948028389 0.027239611670725652 7.499674643519519e-08 7.124957577086844 -0.158334492728188 AQTAPTKT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 AQTAPTKTSPR 11 1 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 AQTAPT(0.024)KT(0.864)S(0.112)PR 129.17 0.027322000000000003 5616300.0 3011.2 4369.4 5207.1 5692.3 4091.3 4015.6 3564.0 4032.6 2109.1 2855.3 True False 3081.3551012247613 3857.828616721047 4500.004420552918 4698.2466627047415 3721.242637377683 3975.2067098730795 3295.1646106071394 3925.6423482691303 3578.9886574307475 3221.805567977241 0.9564062871613139 1.1974119900547329 1.3967337027659847 1.458265113637649 1.1550177559951285 1.2338443850815148 1.022769543686634 1.2184603525698734 1.1108642597814362 1.0 11.653653716453634 -6.998456447550848 2.3939442899931875 1.1070348830645247 1.254234637665214 0.18306021565822306 0.1404177544213361 0.5667427326860421 6.523753125691487 0.06264376278310166 0.04973307880210608 1.0035604843787621e-07 6.998456447550848 0.14719975460068935 AQTAPTKTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 AQTAPTKTSPR 11 1 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 AQTAPT(0.063)KT(0.213)S(0.724)PR 168.93 0.0021401 22196000.0 3992.1 4768.6 5922.6 6286.9 4704.1 4422.3 4774.3 4256.2 2202.3 2991.2 True False 4085.108162725614 4210.2900951380025 5118.343450513093 5189.010934729101 4278.614985576312 4377.815677127137 4414.170707189019 4143.311749913969 3737.1422503720714 3375.149656755338 1.2103487484026965 1.2474380466985031 1.5164789627235535 1.537416548135379 1.2676815610272851 1.297073055224372 1.3078444383507817 1.2275934910385855 1.1072523089138306 1.0 11.720735758461675 -8.189153022479045 0.9095163019178296 0.997697002367007 1.3625644786170017 0.577184962155108 0.10066159542362582 0.42845429719275846 0.7252649215222466 0.10481536700020772 0.03847501874085521 6.469146369749156e-09 8.189153022479045 0.3648674762499947 AQTGPLRS(ph)SLEESPFEA ddPTM_A459_Selumetinib_30min_R1 1 AQTGPLRSSLEESPFEA 17 1 Q86V88 Q86V88 MDP1 Magnesium-dependent phosphatase 1 1 AQT(0.001)GPLRS(0.493)S(0.493)LEES(0.014)PFEA 93.181 0.035493000000000004 6062100.0 1049.2 1397.2 1537.7 1763.4 1376.7 1164.9 1360.3 1012.5 661.23 889.42 True False 1073.644318612187 1233.6151744593421 1328.8887859814904 1455.4552931176408 1252.177728076126 1153.1821636445738 1257.6914758161863 985.645210936491 1122.0590156715823 1003.585720684452 1.0698082849165635 1.2292075794163437 1.3241407869725166 1.450255083467121 1.2477038107139793 1.149061948448306 1.2531978583338477 0.982123590064907 1.1180500006579714 1.0 9.970948133574536 -7.582457381546428 1.3564780149650364 1.027350746216927 1.2676588179193895 0.4329209792738056 0.10505316869720606 0.43803749669774616 1.52085908448517 0.08284366344227782 0.03679744051997651 2.6154270942475198e-08 7.582457381546428 0.2403080717024626 AQTLPT(ph)SVVT(ph)ITSESSPGKR ddPTM_A459_Selumetinib_30min_R1 1 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 2 AQT(0.148)LPT(0.772)S(0.08)VVT(0.455)IT(0.278)S(0.05)ES(0.032)S(0.184)PGKR 112.42 0.00094509 12085000.0 5411.8 5593.5 6276.5 6280.8 4834.3 5697.9 5277.1 4317.5 3319.8 4391.9 True False 5537.884410470298 4938.610419652395 5424.185774346642 5183.976185217916 4397.038418564987 5640.584299279268 4879.044098382416 4202.985874783504 5633.458131401359 4955.643145728726 1.1174905552356822 0.9965629635598334 1.0945472897946158 1.0460753594991985 0.8872790653529601 1.1382143817479862 0.9845430663399704 0.8481211724064639 1.136776391225192 1.0 12.274856587874362 -6.0187610391339765 24.8036541905011 0.9949561493374948 1.0635823534302709 0.11019061060850088 0.09070896310762702 1543.3268211274162 2040408.5599582738 0.02582039376582974 0.03394193407893254 9.577208909359622e-07 6.0187610391339765 0.06862620409277609 AQTLPT(ph)SVVTITSESSPGK ddPTM_A459_Selumetinib_30min_R2 1 AQTLPTSVVTITSESSPGK 19 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(0.017)LPT(0.749)S(0.109)VVT(0.109)IT(0.016)SESSPGK 114.56 0.0011315 19947000.0 41032.0 26902.0 41687.0 38923.0 37639.0 43922.0 36585.0 33831.0 32627.0 33963.0 True False 38751.605704110254 28965.296896436208 39004.903805373804 33621.620254079884 32910.452323070676 49971.8568157815 38286.27499180221 33929.44260897643 39153.311674548735 32982.399943528544 1.174917706730243 0.8782046469034911 1.182597502672844 1.0193806488201524 0.9978186056629883 1.515106750913875 1.1608092515206534 1.0287135765459574 1.1870971106282695 1.0 15.009408758938983 AQTLPT(ph)SVVTITSESSPGKR ddPTM_A459_Selumetinib_30min_R1 1 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(0.091)LPT(0.743)S(0.165)VVTITSESSPGKR 146.81 2.888e-05 475160000.0 1435.3 1297.5 1962.6 2028.8 1663.8 1512.6 1620.9 1644.9 961.8 1188.5 True False 1468.7396973923678 1145.5880968086149 1696.089699790125 1674.508165292655 1513.3095837677483 1497.384617330915 1498.6342080059226 1601.2719086117866 1632.104352907351 1341.0555519703535 1.0952116750379308 0.8542435808311245 1.264742312350995 1.2486493664131768 1.128446604276989 1.1165716551643772 1.1175034515192497 1.1940384619109243 1.2170296379664307 1.0 10.389153285433304 -5.265511220334949 24.999853162826998 1.1666483568322767 0.9747276283446882 0.39981958167894605 0.09100651803396786 290.3115893869995 1782435.3513882959 0.022959510877192557 0.05071493894344367 5.4261123236567025e-06 5.265511220334949 -0.19192072848758857 AQTLPT(ph)SVVTITSESSPGKR ddPTM_A459_Selumetinib_30min_R2 2 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(0.236)LPT(0.382)S(0.382)VVT(0.001)ITSESSPGKR;AQT(0.009)LPT(0.646)S(0.344)VVTITSESSPGKR 97.713 0.0011488 34474000.0 68190.0 68244.0 60162.0 76277.0 64714.0 55339.0 42313.0 53054.0 43404.0 68816.0 True False 64400.272786198075 73478.09536095416 56291.24241943288 65887.94101483583 56584.04876949964 62961.44493257437 44280.638341618855 53208.3783564375 52086.012809087966 66829.10327455951 0.9636560963809004 1.0994924630228546 0.8423162912745803 0.9859168803169925 0.8466977109812581 0.9421261373791696 0.6625951295455373 0.7961857297087637 0.779391167274813 1.0 16.028188895513786 -6.139208291610077 0.8766370982794753 0.8054172039943129 1.0134742512713806 0.289581646973316 0.10329560946507713 0.713698542895548 1.1475106921519405 0.04877328963390275 0.09352640106989088 7.257577938673726e-07 6.139208291610077 0.20805704727706764 AQTLPTS(ph)VVTITSESSPGKR ddPTM_A459_Selumetinib_30min_R2 2 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQT(0.005)LPT(0.013)S(0.974)VVT(0.001)IT(0.002)S(0.004)ES(0.001)SPGKR;AQT(0.003)LPT(0.125)S(0.848)VVT(0.006)IT(0.01)S(0.003)ES(0.003)S(0.002)PGKR 221.81 1.1323999999999996e-42 0.0 28492.0 43605.0 28461.0 40057.0 29128.0 21354.5 22838.5 22660.9 16977.2 29672.0 True False 26908.52870251291 46949.36328782624 26629.850245993788 34601.16749782074 25468.68023237609 24295.88853814958 23900.5355036292 22726.839467286056 20373.114382601798 28815.29226288546 0.9338280679933102 1.6293210861615222 0.9241568679243779 1.2007918289410366 0.8838598616325728 0.8431595389175718 0.8294392881939794 0.7887075813754134 0.7070243881871947 1.0 14.814547032072143 -6.180769474257836 1.2320898290173201 0.8093482628288025 1.2396893039216572 0.3950989109227684 0.19635873389138248 0.4133544552881944 1.2808143018319753 0.07294763601767593 0.11459197316219151 6.595238810132995e-07 6.180769474257836 0.43034104109285476 AQTLPTSVVTITSES(ph)SPGKR ddPTM_A459_Selumetinib_30min_R2 1 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQTLPTSVVTITS(0.067)ES(0.466)S(0.466)PGKR 215.39 3.8739999999999996e-18 504950000.0 52639.0 53002.0 55860.0 58713.0 51566.0 40736.0 52693.0 51913.0 34393.0 46705.0 True False 49713.53511061269 57067.08297170887 52266.02841576942 50716.18811442567 45087.81807411099 46347.01423540993 55143.328909198644 52064.05823534021 41272.56102071151 45356.50529583664 1.0960618501438202 1.2581895937416316 1.1523380841373378 1.118167896393927 0.9940761039684793 1.0218382993379387 1.2157755221555915 1.147885135676872 0.9099590180396899 1.0 15.469021864922292 -1.5228800121227448 0.1137324837549471 0.9471573169287859 1.6831436989770703 0.24680233645784055 0.08956980562984847 161.3359550951734 1.2785716814852104 0.7865386995824861 18.68837478349533 0.02999991248975437 1.5228800121227448 0.7359863820482844 AQTLPTSVVTITSESS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 AQTLPTSVVTITSESSPGK 19 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQTLPTSVVTITS(0.009)ES(0.229)S(0.762)PGK 206.45 4.2586e-30 0.0 30593.0 25923.0 26548.0 24698.0 26492.0 23154.0 25820.0 24498.0 22515.0 22422.0 True False 28892.76353348228 27911.210744417385 24839.930583276873 21334.089793573567 23163.83811851506 26343.25332891502 27020.68116135937 24569.28512413776 27018.629121661957 21774.618600647667 1.3269010155072425 1.281823174785123 1.1407745430056824 0.9797687015716088 1.0637999472388495 1.209814684337638 1.2409255774774244 1.1283451423303905 1.2408313374939348 1.0 14.410359828671034 -1.5228787591101387 0.015232234879457079 1.4582704422972576e-10 2.562753032619581 0.20032622021793667 0.10075784193107191 11927.844060216627 14.078324816117654 943.9751226887095 1480.2749631471183 0.029999999044671197 1.5228787591101387 2.562753032473754 AQTLPTSVVTITSESS(ph)PGKR ddPTM_A459_Selumetinib_30min_R1 2 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQTLPTSVVTIT(0.001)S(0.045)ES(0.045)S(0.909)PGKR;AQTLPTSVVTITS(0.003)ES(0.236)S(0.761)PGKR 225.56 6.5586000000000006e-21 2365800000.0 10574.3 11391.599999999999 12007.5 11738.8 10149.3 10098.3 10277.1 9852.099999999999 5754.6 9298.2 True False 10820.660615993955 10057.866176188838 10376.947452476272 9688.838944566949 9231.29760700445 9996.720270522786 9501.890072859327 9590.790303869044 9765.135900645299 10491.714542137766 1.0313529378382384 0.958648477881621 0.9890611692492627 0.9234752723831519 0.8798654948082015 0.9528204594561795 0.9056565573431284 0.9141299322765264 0.9307473875147558 1.0 13.356962840049517 -4.858824708164234 0.9724469522676511 0.9250533083212195 1.0656234523383061 0.41942417684095024 0.03403528695204676 1.61887152175019 1.3256547821951088 0.011150258672047306 0.23369218261111413 1.3841249327924048e-05 4.858824708164234 0.14057014401708667 AQTLPTSVVTITSESS(ph)PGKR ddPTM_A459_Selumetinib_30min_R2 3 AQTLPTSVVTITSESSPGKR 20 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 AQTLPTSVVTITS(0.002)ES(0.075)S(0.923)PGKR;AQTLPTSVVTIT(0.003)S(0.285)ES(0.176)S(0.535)PGKR;AQTLPTSVVT(0.001)IT(0.011)S(0.059)ES(0.25)S(0.679)PGKR 219.65 8.7168e-20 677594000.0 338406.0 288563.0 288934.0 321787.0 327041.0 229932.0 283157.0 248062.0 190810.0 298224.0 True False 319598.7492665515 310694.85422371305 270344.3010075532 277959.0554864631 285955.18579636456 261603.04588512087 296324.36156495113 248783.81935112542 228977.33167685225 289613.4982409932 1.1035354056619522 1.0727913447085868 0.9334658178901395 0.959758634092282 0.9873682944101436 0.9032833326968612 1.0231717905578204 0.8590201108102614 0.7906307304997077 1.0 18.143769319231957 -1.522878931780773 0.4098654951429667 0.9064643464257651 4.633033208207015 0.4614375972690923 0.06659978217065471 67.49897290876685 0.8808180099465225 0.04742195173503656 204.68169714160356 0.029999987117009096 1.522878931780773 3.7265688617812502 AQTPPGPS(ph)LSGSK ddPTM_A459_Selumetinib_30min_R2 1 AQTPPGPSLSGSK 13 0 Q9UQ35;Q9UQ35-2;I3L4D8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQT(0.295)PPGPS(0.58)LS(0.116)GS(0.008)K 91.712 0.019423 50237000.0 17781.0 14119.0 16263.0 19742.0 18394.0 15088.0 19118.0 18611.0 17313.0 15667.0 True False 16792.80320298267 15201.881900259576 15216.656285815572 17053.105543150443 16083.181275553612 17166.235044772806 20007.02488159831 18665.1549287831 20776.083765637723 15214.65300224542 1.1037256781672473 0.9991606051098266 1.000131668041976 1.1208343391488256 1.0570849872935 1.1282699015376405 1.314983974898778 1.2267880789675878 1.36553122588938 1.0 13.893173810500324 -7.0283133576975 3.8354634945655066 1.2452970796943315 1.0548465151881365 0.4032748401109776 0.09648684151530615 0.1992847694887441 6.335096334447885 0.035551313792256595 0.028511234109434316 9.368857692136739e-08 7.0283133576975 -0.1904505645061949 AQTPPGPS(ph)LSGSKSPCPQEK ddPTM_A459_Selumetinib_30min_R2 1 AQTPPGPSLSGSKSPCPQEK 20 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQTPPGPS(0.82)LS(0.058)GS(0.049)KS(0.072)PCPQEK 59.733 0.017339 277430000.0 139510.0 135800.0 156330.0 147160.0 125250.0 112580.0 124400.0 117660.0 90115.0 130510.0 True False 131756.59270277875 146215.4233341771 146271.89799923406 127116.55413484054 109514.97525079327 128086.87310051183 130184.8464939237 118002.37112033828 108140.51802347635 126741.83719429666 1.0395666941516275 1.153647655509579 1.1540932436934586 1.002956537074411 0.8640791207950188 1.0106124065737916 1.0271655309394707 0.9310451365750626 0.8532345783949441 1.0 16.951533307909763 -5.909016286486178 4.847535661887784 0.9498913851625281 1.1181786137868261 0.5951478681535293 0.06182533512007981 0.14611598219068472 5.8941536587921295 0.018238310218765538 0.027571532730455508 1.2330585914066003e-06 5.909016286486178 0.168287228624298 AQTPPGPSLSGSKS(ph)PCPQEK ddPTM_A459_Selumetinib_30min_R1 2 AQTPPGPSLSGSKSPCPQEK 20 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQTPPGPS(0.002)LS(0.001)GS(0.039)KS(0.959)PCPQEK;AQTPPGPS(0.045)LS(0.006)GS(0.102)KS(0.847)PCPQEK 90.545 0.00092083 493100000.0 11223.0 12849.900000000001 14587.1 13763.2 11976.3 10914.0 11597.8 11039.8 6164.5 9182.0 True False 11484.474063843485 11345.427734243556 12606.251941204784 11359.715487261381 10893.0457795875 10804.215069119142 10722.968608557658 10746.98864167572 10460.706262733802 10360.599140253922 1.1084758620978765 1.0950551778577449 1.2167493183117037 1.096434224843774 1.0513914911797784 1.042817594123649 1.0349757251871492 1.0372941271244212 1.00966229086993 1.0 13.338819814203235 -6.213899188449595 2.7872869534951126 1.0300659028833232 1.1374636439365016 0.693687472611485 0.03332670722507494 0.16201436709208183 2.4959273901111523 0.010804702749663261 0.014033208076575725 6.110838576117562e-07 6.213899188449595 0.10739774105317834 AQTPPGPSLSGSKS(ph)PCPQEK ddPTM_A459_Selumetinib_30min_R2 3 AQTPPGPSLSGSKSPCPQEK 20 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 AQTPPGPS(0.003)LS(0.002)GS(0.03)KS(0.965)PCPQEK;AQTPPGPS(0.038)LS(0.038)GS(0.197)KS(0.727)PCPQEK;AQT(0.001)PPGPS(0.027)LS(0.081)GS(0.106)KS(0.785)PCPQEK 84.125 0.001451 485242000.0 372117.0 352324.0 378919.0 404239.0 353334.0 282916.0 316736.0 319328.0 221636.0 336578.0 True False 351436.226842377 379346.11789978464 354539.76407581294 349180.9508488301 308945.02407396195 321885.1109442566 331464.85160047736 320257.1916124041 265969.3930272554 326860.11860533385 1.0751884578085142 1.160576333137249 1.0846834590545469 1.0682886377779464 0.9451903321585604 0.9847793983484283 1.0140877786338427 0.9797989212599459 0.8137101404787755 1.0 18.318313833798655 -6.083687604016575 2.2000862363512934 0.9581686773557591 1.1143165308062506 0.6005727036204884 0.05660699568885716 0.22068524926025462 2.1115006999381944 0.018447102297319516 0.026949007447628293 8.247311459327656e-07 6.083687604016575 0.15614785345049154 AQTPPIS(ph)SLPTSPSDEVGR ddPTM_A459_Selumetinib_30min_R2 1 AQTPPISSLPTSPSDEVGR 19 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 AQT(0.423)PPIS(0.558)S(0.019)LPTSPSDEVGR 188.09 2.5915e-15 9813800.0 16728.0 15742.0 19719.0 18692.0 21769.0 13837.0 18160.0 18351.0 15112.0 12398.0 True False 15798.324727489678 16949.360781492054 18450.301008423856 16146.117354501466 19034.183602670793 15742.92115022013 19004.475983357337 18404.3983718284 18134.822264559418 12040.037526127455 1.3121491268782643 1.4077498300741285 1.532412251073622 1.341035467660597 1.5809073320050464 1.307547515201447 1.5784399294534357 1.528599751611237 1.5062097792640587 1.0 13.55555226821464 -10.567541128564013 5.31154406621353 0.9999961429961669 1.4577013243164172 0.6449096838392238 0.10127022925317579 4.472812031987368e-06 8.046576268197627e-07 0.09481624802376479 0.022996124078564047 2.706816850763781e-11 10.567541128564013 0.4577051813202503 AQTSYGFAMLAES(ph)PHTR ddPTM_A459_Selumetinib_30min_R2 2 AQTSYGFAMLAESPHTR 17 0 Q8TF44 Q8TF44 C2CD4C C2 calcium-dependent domain-containing protein 4C 1 AQTSYGFAMLAES(0.994)PHT(0.006)R;AQTSYGFAMLAES(0.999)PHT(0.001)R 147.0 0.00026889 5805900.0 29234.0 28085.0 32453.0 31597.0 31997.0 23488.0 28273.0 25930.0 21939.3 30159.0 True False 27609.29131297424 30239.029192491682 30365.009312154754 27293.434092134758 27977.25080319065 26723.258797164897 29587.75052188668 26005.452007057418 26327.773035259954 29288.231307507474 0.9426752685436874 1.0324634791019454 1.0367648695935854 0.931890826918545 0.9552386591545123 0.9124230997969107 1.0102266064220282 0.887914730460061 0.8989198684903631 1.0 14.838033452215916 -5.77329817078995 24.99996975928201 0.9398185104311644 1.0068174341097798 0.2865122848858179 0.04434607202245752 250.35139850708762 527775.2143382131 0.012341845225114684 0.018465237368600472 1.6853954968488367e-06 5.77329817078995 0.06699892367861537 AQTTNSNSSSS(ph)SDVSTHS ddPTM_A459_Selumetinib_30min_R2 1 AQTTNSNSSSSSDVSTHS 18 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 AQTTNSNS(0.002)S(0.007)S(0.381)S(0.587)S(0.023)DVSTHS 160.03 1.4026e-05 1835400.0 3136.3 2200.0 2548.2 4324.6 5091.1 3597.6 3574.8 4340.2 2265.4 3389.0 True False 2961.9970016036505 2368.732925885052 2384.251586270385 3735.5820196488894 4451.510502988527 4093.136744238778 3741.035283331817 4352.82926344121 2718.543300564646 3291.15076432053 0.8999882453623074 0.7197278689158092 0.7244431376763812 1.1350382547485982 1.3525696091614805 1.243679502201055 1.1366952021428187 1.3225857990555676 0.8260160336732246 1.0 11.684376401053127 -5.793294944728527 7.020653104638958 1.1723994964946722 0.7749661410227995 0.5391043351850868 0.15277516947504724 0.12204960286602316 19.17792271451308 0.04195433781794308 0.06397043884492508 1.609552160165782e-06 5.793294944728527 -0.39743335547187275 AQTTNSNSSSSSDVS(ph)THS ddPTM_A459_Selumetinib_30min_R2 1 AQTTNSNSSSSSDVSTHS 18 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 AQTTNSNSSS(0.017)S(0.004)SDVS(0.976)T(0.002)HS 226.74 8.8579e-52 0.0 1282.2 697.55 1091.4 2135.0 2708.0 2008.6 1059.9 2354.4 3143.0 2733.0 True False 1210.9404570532806 751.0498420232354 1021.1805122264722 1844.2093169195714 2367.7968301728374 2285.266417744609 1109.1874501520067 2361.250914208099 3771.687822757431 2654.0911888132227 0.4562542772295449 0.28297816035441775 0.384757131379157 0.6948552953616526 0.8921309260785415 0.8610353809156295 0.4179161043249535 0.8896645767713552 1.4210844897322243 1.0 11.37400222409234 -6.137163343205895 0.3572763385986446 1.1126168021761516 0.1255967738120653 0.548769438053117 0.224005558331807 2.128209096495463 0.43348528198993297 0.25838037060537367 0.8358147403585809 7.291832043887356e-07 6.137163343205895 -0.9870200283640862 AQVLATIHGHAGAFPAAGDAGEGAPGGGS(ph)SPER ddPTM_A459_Selumetinib_30min_R1 1 AQVLATIHGHAGAFPAAGDAGEGAPGGGSSPER 33 0 Q86WR7;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 AQVLATIHGHAGAFPAAGDAGEGAPGGGS(0.5)S(0.5)PER 82.986 9.0042e-07 82822000.0 1049.7 1114.1 957.83 1077.5 1246.2 1042.4 974.22 1014.4 392.32 622.74 True False 1074.1559676393576 983.6606540689613 827.7619469835803 889.3348521800261 1133.48143003448 1031.9144024234736 900.7338010509781 987.4948167644206 665.7383860809023 702.6747450012768 1.5286673888320916 1.3998804725323861 1.1780157930424497 1.2656422598173926 1.6130954443686747 1.4685520004302965 1.2818644863198283 1.405336998076722 0.9474346286341806 1.0 9.456713237025575 -8.2607154259408 24.98461080331156 0.9737172658106684 1.3876738406090448 0.6529696826703879 0.12211541206265521 40.822584595179336 1408981.7741931172 0.10157940880049998 0.03318950184914792 5.486363444143381e-09 8.2607154259408 0.41395657479837633 AQVLATIHGHAGAFPAAGDAGEGAPGGGS(ph)SPER ddPTM_A459_Selumetinib_30min_R2 1 AQVLATIHGHAGAFPAAGDAGEGAPGGGSSPER 33 0 Q86WR7;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 AQVLATIHGHAGAFPAAGDAGEGAPGGGS(0.5)S(0.5)PER 77.233 4.917e-06 12637000.0 42099.0 35047.0 41268.0 40729.0 42445.0 31226.0 31301.0 34966.0 25358.0 40250.0 True False 39759.30611564971 37734.99220613339 38612.86180920108 35181.6399385561 37112.67963688557 35527.098058594616 32756.558521754854 35067.745271067084 30430.30856171903 39087.877917940816 1.0171774021377795 0.9653886119208721 0.9878474827992207 0.9000652328175687 0.9494677535270173 0.9089032188746208 0.8380234555204653 0.8971514223587834 0.7785101208513528 1.0 15.254433642345838 -5.977478408160015 0.750403096058609 0.8725553414830112 1.0084804099455738 0.36587572019695935 0.05685541448584259 0.84857920381309 0.9337604712567785 0.02869241623606344 0.07440229990168688 1.0532260491190296e-06 5.977478408160015 0.13592506846256258 AQVLATIHGHAGAFPAAGDAGEGAPGGGSS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 AQVLATIHGHAGAFPAAGDAGEGAPGGGSSPER 33 0 Q86WR7;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 AQVLATIHGHAGAFPAAGDAGEGAPGGGS(0.371)S(0.629)PER 210.69 6.266199999999997e-66 51993000.0 882.18 964.81 1153.7 1225.3 1129.9 888.63 963.6 809.19 464.91 636.11 True False 902.7330775765334 851.8495966719995 997.0338768204765 1011.3243567296388 1027.7007445000468 879.6911890114837 890.9148762011893 787.7276525804435 788.918314317069 717.7609147361059 1.2577072100790485 1.186815246111852 1.3890891191630976 1.4089989242468925 1.4318148611893897 1.2256047535479326 1.241241836815182 1.0974791694669832 1.0991380251000782 1.0 9.487359553926687 -7.704617520236234 1.2495066306656633 1.0332644273538651 1.3290235015026024 0.6978744199601821 0.07542573930614012 0.29604878243013405 0.8485397393863404 0.06884641156648201 0.02781619719167731 1.974160598587061e-08 7.704617520236234 0.29575907414873726 AQVPGPLT(ph)PEMEAR ddPTM_A459_Selumetinib_30min_R1 1 AQVPGPLTPEMEAR 14 0 Q9H8Y5;B8ZZS4 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 1 AQVPGPLT(1)PEMEAR 157.35 0.00073427 11850000.0 1922.3 2462.7 2327.2 2998.2 2669.3 2054.2 2362.0 2230.5 1257.7 1905.9 True False 1967.0858498553253 2174.365939121832 2011.1790223945663 2474.6206531843654 2427.862286303191 2033.5366130643702 2183.83243834289 2171.3398943149073 2134.2250412264243 2150.540830038111 0.9146935609776194 1.0110786592614003 0.9351968557411324 1.1506968938322883 1.1289542855413564 0.9455931199540781 1.0154805748580877 1.0096715505170983 0.9924131694763509 1.0 11.07048380712545 -3.3312663767340362 9.234259269619573 1.014111131497412 0.965426036342271 0.0 0.07304201625474112 0.0 0.0 0.01738073796429462 0.0 0.00046637324016658054 3.3312663767340362 -0.04868509515514108 AQVPGPLT(ph)PEMEAR ddPTM_A459_Selumetinib_30min_R2 2 AQVPGPLTPEMEAR 14 0 Q9H8Y5;B8ZZS4 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 1 AQVPGPLT(1)PEMEAR;AQVPGPLT(1)PEMEAR 137.39 0.0013735 25979000.0 57373.0 53359.0 60403.0 65232.0 62493.0 41287.0 41266.0 50405.0 38919.0 42217.0 True False 54184.43834231618 57451.46372377298 56516.736741813824 56347.28906852341 54642.070645491534 46973.90948392993 43184.950767027745 50551.67020500307 46703.88748771758 40998.085517061045 1.32163338016766 1.4013206470303348 1.3785213633523157 1.3743883002798973 1.3327956648793429 1.1457586102253992 1.0533406675552364 1.2330251417219562 1.1391724003376231 1.0 15.323268921486765 -6.740992586223383 3.7297935324479337 1.1218386051150844 1.3699881350795267 0.8122919182958753 0.05972695825733777 0.09662591173212846 2.8781876318001802 0.020813593820341918 0.019699993373617414 1.8155466554359837e-07 6.740992586223383 0.24814952996444228 AQYDELAR ddPTM_A459_Selumetinib_30min_R1 4 AQYDELAR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ;;; 154.12 0.01057 332724000.0 21271.3 22706.4 22994.699999999997 25658.300000000003 24630.9 19637.3 23737.7 21652.199999999997 12539.7 17996.1 False True 21766.87990325527 20047.924132081036 19872.146040845793 21177.55957094269 22403.03944393859 19439.76659124181 21947.146177668077 21077.913319742314 21278.95503654846 20306.074731858364 1.0719393181935373 0.9872870260162929 0.978630597161559 1.042917444685508 1.1032678516045389 0.9573374888029247 1.080816773673891 1.038010230833683 1.0479108009567077 1.0 14.309623765801591 -5.827222718936335 24.983090749385727 1.0412590328311346 1.010085067733333 0.06460199649540288 0.044212759059854584 133.83806127545918 50827.195258295964 0.01212028426469297 0.017977289733269577 1.4885974855208752e-06 5.827222718936335 -0.03117396509780157 ARAEEAEAQKR ddPTM_A459_Selumetinib_30min_R2 1 ARAEEAEAQKR 11 2 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 68.626 0.045302 711450.0 2390.9 3455.1 842.19 943.29 956.13 2202.2 3423.3 7386.3 2845.0 4714.5 False True 2258.02334953103 3720.0950601024756 788.0044123071407 814.8122747339871 836.0124014893486 2505.533060418787 3582.4902331402614 7407.792910132205 3414.0794959417376 4578.380135257937 0.49319263207134667 0.812535209004198 0.17211423888522226 0.17796955487796826 0.182600041235381 0.5472531739170737 0.7824798569152518 1.617994288653549 0.7456959437793375 1.0 12.16062153708904 -7.374167611150433 2.8887214125186396 1.1415234443908093 0.37923296591796474 0.574191396737645 0.27817913280432716 0.19053953751657352 3.0630267509471607 0.13416939217947577 0.08390742315469037 4.225055214641161e-08 7.374167611150433 -0.7622904784728446 AREES(ph)WGPPR ddPTM_A459_Selumetinib_30min_R2 4 AREESWGPPR 10 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 AREES(1)WGPPR;AREES(1)WGPPR;AREES(1)WGPPR;AREES(1)WGPPR 98.368 0.010799 60675000.0 52203.1 41711.8 59567.9 66673.9 60208.9 52472.0 52950.0 51248.1 44714.2 50988.2 True False 49301.86068756675 44910.96093542368 55735.366166625674 57592.79980110722 52644.919707604626 59699.54170660913 55412.27991843455 51397.223486420335 53658.289419134686 49516.03818274656 0.9956745833665174 0.9069982693218077 1.1256022939663655 1.1631140518260392 1.0631892542232568 1.2056607090874027 1.1190774131388905 1.0379914341436398 1.0836547387151716 1.0 15.595608267551608 -5.267170009372717 24.929123429872245 1.1065679517135287 0.9513364225749521 0.49264559393702667 0.05994461816735128 309.17753733325793 1344975.614371939 0.015489769767609764 0.03370444970404565 5.405426801196593e-06 5.267170009372717 -0.15523152913857663 ARFEELCSDLFR ddPTM_A459_Selumetinib_30min_R1 2 ARFEELCSDLFR 12 1 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37;P17066;P48741 A0A0G2JIW1;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 ; 140.45 0.0030252 144175000.0 6558.0 6455.4 9153.7 9337.7 9114.0 6706.6 7306.3 7647.1 4620.4 6542.7 False True 6710.788640353345 5699.59876696596 7910.677817674951 7707.045985337757 8289.640309207394 6639.1376931055875 6755.179908664125 7444.27406671846 7840.481339335746 7382.519276294849 0.9090106492375278 0.7720398083168276 1.0715417761354191 1.0439588028012277 1.1228741841318717 0.8993051619145448 0.9150236736062307 1.0083650022590398 1.0620333040661887 1.0 12.84989750300793 -5.263409538440661 24.999093903260448 1.0128154490124552 0.840525225421041 0.4895013307808386 0.0713907484252599 144.56917701218993 1834447.273015002 0.019698830887952247 0.04462236218237858 5.452434555859061e-06 5.263409538440661 -0.17229022359141422 ARFEELNADLFR ddPTM_A459_Selumetinib_30min_R1 2 ARFEELNADLFR 12 1 P11142;E9PKE3;P11142-2;E9PN89;E9PNE6;A8K7Q2;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 ; 184.34 0.00029424 324600000.0 7310.700000000001 6614.5 9183.2 9932.1 8562.5 6784.1 6873.5 7161.3 4207.6 5812.5 False True 7481.0250858541 5840.071265002374 7936.171879706856 8197.645183607649 7788.02338683216 6715.858113469955 6355.026361113405 6971.35906081925 7139.989889054864 6558.590993544531 1.1406451619284539 0.8904460227433943 1.2100422007590115 1.2499094991098547 1.1874537373191485 1.0239787966775515 0.9689621394852203 1.0629354792334202 1.0886469206697889 1.0 12.679170193260987 -6.779752333504632 24.883945270153838 1.0290916880255845 1.1325493083969698 0.23895189466643174 0.09521180044291547 402.1709501392175 546472.7897462993 0.03658807711445282 0.03233006340801605 1.6605335952508752e-07 6.779752333504632 0.10345762037138528 ARFEELNADLFR ddPTM_A459_Selumetinib_30min_R2 1 ARFEELNADLFR 12 1 P11142;E9PKE3;P11142-2;E9PN89;E9PNE6;A8K7Q2;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 146.5 0.0018448 2983300.0 9780.8 8635.7 11481.0 9534.1 10966.0 11724.0 8929.0 6149.7 8067.4 10536.0 False True 9237.222291644615 9298.030421847974 10742.324959567652 8235.53913276014 9588.353042716148 13338.87458012436 9344.216192477843 6167.594608862359 9681.105421989596 10231.79830418445 0.9027955807012841 0.9087386347369066 1.0498960828004607 0.8048965477937626 0.9371131796836577 1.3036686400150423 0.9132525793297139 0.6027869613438359 0.9461782898936113 1.0 13.320772109825647 -7.528121270998886 24.99909581745114 0.8162935241874669 0.9849538244968613 0.11896714017570176 0.15788219877601112 252.1357357074104 1202288.3740070653 0.07426147187099169 0.04305440095693616 2.9640036150895658e-08 7.528121270998886 0.16866030030939438 ARGDS(ph)EALDEES ddPTM_A459_Selumetinib_30min_R2 1 ARGDSEALDEES 12 1 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;A0A087WZ99 Q7Z4V5-2 HDGFRP2 Hepatoma-derived growth factor-related protein 2 1 ARGDS(0.998)EALDEES(0.002) 118.73 0.021124 88002000.0 265450.0 260970.0 273500.0 298020.0 280600.0 228430.0 212950.0 237900.0 198400.0 252510.0 True False 250697.35168054365 280985.5598491923 255903.30776428408 257429.1618868245 245348.5194041722 259894.1590189195 222852.59695241958 238592.24961353507 238085.5437591712 245219.3802002291 1.0223390642119787 1.1458538049470601 1.0435688547753903 1.0497912590620926 1.0005266272341022 1.0598434708003421 0.9087886804479061 0.9729746866610511 0.9709083497591712 1.0 17.903713477176254 -6.512608027797686 0.9445896359490967 0.9653160961320822 1.080183909578544 0.475033083140851 0.04382105597302714 0.4487301280680773 0.8702579536404736 0.02270005685488832 0.027211896231609693 3.071793182573295e-07 6.512608027797686 0.11486781344646169 ARGDSEALDEES(ph) ddPTM_A459_Selumetinib_30min_R2 1 ARGDSEALDEES 12 1 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;A0A087WZ99 Q7Z4V5-2 HDGFRP2 Hepatoma-derived growth factor-related protein 2 1 ARGDS(0.006)EALDEES(0.994) 107.34 0.040447 112720000.0 85476.0 88075.0 105670.0 99258.0 106690.0 80739.0 80551.0 85216.0 71377.0 97827.0 True False 80725.58610753872 94830.0692942391 98871.30724479714 85738.8891703994 93286.64837929842 91860.06437433149 84296.78110877846 85463.96445173174 85654.39444001178 95002.4803249289 0.8497208265662104 0.9981851944275548 1.0407234306581894 0.9024910599928968 0.9819390826454009 0.966922800964252 0.8873113714554122 0.8995971911409746 0.9016016649992226 1.0 16.535677559369482 -7.24467880279193 24.16485191335247 0.9137606555159902 0.9610584561067221 0.07053043145868387 0.05701467942835148 1080.6768086035884 1558085.7411170597 0.021463296183479145 0.01657151490020806 5.692738009299754e-08 7.24467880279193 0.047297800590731964 ARGGCPGGEATLS(ph)QPPPR ddPTM_A459_Selumetinib_30min_R1 1 ARGGCPGGEATLSQPPPR 18 1 P20290 P20290 BTF3 Transcription factor BTF3 1 ARGGCPGGEATLS(1)QPPPR 169.43 5.4071e-08 15592000.0 1451.4 1682.7 2223.3 2111.9 1861.2 1486.3 1483.5 1320.5 1163.3 1008.4 True False 1485.2147960672216 1485.6887017339939 1921.3880717127188 1743.0963102728517 1692.8547886215486 1471.3491714524246 1371.598400627297 1285.4760504114934 1974.0351359296324 1137.837962647795 1.3052955208236037 1.3057120174446775 1.6886306616467348 1.5319372067852228 1.4877819550704803 1.293109581287423 1.2054426426725402 1.1297531745382607 1.7349000479259566 1.0 10.152079405462047 -6.787536853795198 6.762926977196417 1.2755297720035341 1.4715290653823725 0.17853141260162353 0.2048173971337262 0.31847646797071827 50.32345492072399 0.07150475322508275 0.06457001683294451 1.6310344953997537e-07 6.787536853795198 0.19599929337883837 ARGPGGS(ph)PGGLQK ddPTM_A459_Selumetinib_30min_R1 3 ARGPGGSPGGLQK 13 1 Q96A00-2;Q96A00;K7EJB8;K7EMN0 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 ARGPGGS(1)PGGLQK;ARGPGGS(1)PGGLQK;ARGPGGS(1)PGGLQK 157.37 0.0017324000000000007 116888000.0 7240.8 7058.9 13299.5 14514.7 10607.8 8589.3 7791.1 7352.700000000001 4831.0 6011.799999999999 True False 7409.496551855826 6232.44070640642 11493.50094892427 11979.980119663504 9648.326362959197 8502.899440460418 7203.411054349403 7157.682511064429 8197.854157720329 6783.473089890925 1.0922865696773874 0.9187683984026292 1.6943386959185358 1.7660540494391697 1.4223283906495658 1.2534728637947823 1.0619060411818086 1.0551648714772923 1.2085039697344988 1.0 12.727808396761912 -7.036198969650676 3.3719681669757806 1.0877154671305997 1.390643968059802 0.25441839929956844 0.2389074997234844 0.404922957301332 9.406560163846974 0.10754205065629181 0.08543576130322461 9.20027969381635e-08 7.036198969650676 0.3029285009292022 ARGPGGS(ph)PGGLQK ddPTM_A459_Selumetinib_30min_R2 2 ARGPGGSPGGLQK 13 1 Q96A00-2;Q96A00;K7EJB8;K7EMN0 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 ARGPGGS(1)PGGLQK;ARGPGGS(1)PGGLQK 119.96 0.0017198 103948000.0 193024.0 250980.0 228450.0 236360.0 219847.0 103695.0 81699.0 80972.0 60845.0 186417.0 True False 182296.49881629404 270229.3589721048 213751.77571755304 204167.36025625814 192227.85440288304 117978.04500051151 85498.16538349725 81207.61511436381 73015.70015134438 181034.6568404665 1.0069701680211405 1.4926940713359627 1.180722959062573 1.127780524566503 1.0618290318426729 0.6516876219147228 0.47227512607622396 0.44857496642715516 0.4033244320488764 1.0 17.465906384262972 -6.708964878146669 2.0764112777656076 0.5302076999110368 1.2238758978453665 0.6913765836721391 0.19422497141196923 0.16157103106836776 1.431950092433917 0.07265402063238825 0.06922257866113081 1.9544975116617925e-07 6.708964878146669 0.6936681979343298 ARGS(ph)PPTSSNIVQGQIK ddPTM_A459_Selumetinib_30min_R1 1 ARGSPPTSSNIVQGQIK 17 1 A2RRE0;Q9Y4E6-2;Q9Y4E6 A2RRE0 WDR7 WD repeat-containing protein 7 1 ARGS(0.428)PPT(0.428)S(0.113)S(0.031)NIVQGQIK 101.01 0.019734 9497600.0 2432.5 3037.5 3289.2 3901.0 3047.3 2790.1 2885.1 2514.5 1574.8 2580.3 True False 2489.172517178942 2681.8680879045605 2842.5447062823173 3219.763580839242 2771.6722530445127 2762.03412720811 2667.4745841926633 2447.8072917528953 2672.3205811587613 2911.5066392504 0.8549431018367204 0.9211272444822718 0.976314004564373 1.1058754039689245 0.9519718126962989 0.948661455884307 0.9161835828337436 0.8407356036059429 0.9178480121366923 1.0 11.507550193286342 -7.151433844356947 2.7760699510979427 0.9048609024607623 0.9675126087028828 0.06603224163778676 0.06904367040763783 0.6105836194497876 9.112648239854607 0.03162734261598645 0.0231277742346865 7.056123210820129e-08 7.151433844356947 0.06265170624212046 ARGS(ph)PPTSSNIVQGQIK ddPTM_A459_Selumetinib_30min_R2 3 ARGSPPTSSNIVQGQIK 17 1 A2RRE0;Q9Y4E6-2;Q9Y4E6 A2RRE0 WDR7 WD repeat-containing protein 7 1 ARGS(0.999)PPTSSNIVQGQIK;ARGS(1)PPTSSNIVQGQIK;ARGS(0.994)PPT(0.004)S(0.001)SNIVQGQIK 131.41 0.00043214 30880800.0 325398.0 281671.0 340212.0 375841.0 377511.0 269272.0 270822.0 294287.0 242356.0 328899.0 True False 307313.6818314016 303274.2599849853 318323.1303148183 324650.80743811256 330084.69318883953 306361.7737921571 283415.7596236125 295143.32644816424 290833.9719924269 319402.8312877715 0.9621507755343659 0.9495039814213327 0.9966196261673697 1.01643058744715 1.0334432285963175 0.9591705012662682 0.8873301419431193 0.9240473080911726 0.9105553974579361 1.0 18.28501757574802 -7.001462774631506 24.976264854061363 0.9240247459123349 0.991480631428609 0.3983996675686138 0.03511724046235672 52.057851050069374 888881.5831343121 0.012760171928875802 0.011104052372627182 9.966375028372796e-08 7.001462774631506 0.06745588551627413 ARHDS(ph)PDLAPNVTYSLPR ddPTM_A459_Selumetinib_30min_R1 3 ARHDSPDLAPNVTYSLPR 18 1 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 ARHDS(1)PDLAPNVTYSLPR;ARHDS(1)PDLAPNVTYSLPR;ARHDS(1)PDLAPNVTYSLPR 146.34 0.00013579 76871000.0 2119.29 2279.41 2678.89 2894.4900000000002 2567.46 2160.04 2208.19 2051.2799999999997 1305.6599999999999 2032.94 True False 2168.66533357951 2012.535617531041 2315.1114520894553 2389.0216578065542 2335.23369632188 2138.3119587594006 2041.6244504760314 1996.8733909035102 2215.609658366618 2293.8876515125016 0.9454104398485145 0.8773470732989265 1.0092523278387062 1.041472827246498 1.0180244419477633 0.9321781549979048 0.890028092321724 0.8705192643531815 0.9658754023570989 1.0 11.163579018398154 -6.936737651341405 8.891024087634243 0.9194373650874534 0.9778032032327573 0.13985555197130295 0.05450421736826506 0.5340818514816932 69.15843644508345 0.02071376065828546 0.018260150498070532 1.1568108375856004e-07 6.936737651341405 0.05836583814530383 ARHDS(ph)PDLAPNVTYSLPR ddPTM_A459_Selumetinib_30min_R2 2 ARHDSPDLAPNVTYSLPR 18 1 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 ARHDS(1)PDLAPNVTYSLPR;ARHDS(1)PDLAPNVTYSLPR 90.378 0.0031727 60057000.0 16667.9 18734.9 15893.2 24427.7 21208.0 14673.099999999999 8631.3 14759.099999999999 13557.7 20616.4 True False 15741.56484489033 20171.80658780177 14870.64881520778 21100.605119867083 18543.66143807443 16694.186335860024 9032.672552596481 14802.046537499467 16269.618833788867 20021.15096415987 0.7862467484047003 1.0075248233186789 0.7427469500543663 1.0539156893447112 0.9262035669812232 0.8338275040103593 0.4511565078733979 0.7393204598475286 0.8126215552199435 1.0 14.289237292911974 -7.008642330247252 24.539406895359125 0.7166857233245009 0.9057066277159048 0.1673451096963504 0.1529928996745008 453.36818401134485 1287314.4055746726 0.05378689542487026 0.0451256630164099 9.802969913839273e-08 7.008642330247252 0.18902090439140395 ARLGDAS(ph)DTEAADGER ddPTM_A459_Selumetinib_30min_R1 1 ARLGDASDTEAADGER 16 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 ARLGDAS(0.966)DT(0.034)EAADGER 209.19 2.6816999999999995e-07 4832800.0 806.3 870.47 1382.1 1115.2 909.96 793.88 1030.7 899.77 487.38 774.22 True False 825.0852212133123 768.5549677294755 1194.4184113318709 920.451254896673 827.6542786664869 785.8942879853673 952.9534691786689 875.9051767351372 827.0482631732009 873.5986785414275 0.9444671122796179 0.8797574751517088 1.3672392606248998 1.0536316932547005 0.9474078876222088 0.8996056281787278 1.0908366651489598 1.0026402262850953 0.9467141875192076 1.0 9.770826863725746 -6.148127748490235 6.752956141126188 0.9830502926657113 1.0714978420119476 0.08536535512694077 0.1274069144098615 0.6742008270070287 35.72207856818731 0.039594780174688156 0.051356333175565295 7.110043397059128e-07 6.148127748490235 0.08844754934623633 ARLGEAS(ph)DSELADADK ddPTM_A459_Selumetinib_30min_R1 1 ARLGEASDSELADADK 16 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 ARLGEAS(0.996)DS(0.004)ELADADK 142.35 0.0018732 7842000.0 937.63 1008.3 1450.9 1191.4 1271.7 1016.2 1236.0 1089.5 844.57 1130.1 True False 959.4749546896162 890.2477672540466 1253.8757492232205 983.3443553478269 1156.6749595368701 1005.977950635776 1142.767524890691 1060.6029208052419 1433.1736050477875 1275.1593431061808 0.7524353406315606 0.6981462921217971 0.9833090711384231 0.7711540998103679 0.9070826840505338 0.7889037209932512 0.8961762552019621 0.8317414812032059 1.1239172679052778 1.0 10.316461821272055 -8.251666306049449 24.73165969949197 1.0619586325579495 0.8310539555652872 0.5540136904030393 0.08372042346329367 373.760119051776 945840.9838953486 0.056611630074083735 0.02079521097179481 5.6018786140296355e-09 8.251666306049449 -0.23090467699266237 ARLS(ph)PVTPSESLPRPR ddPTM_A459_Selumetinib_30min_R2 1 ARLSPVTPSESLPRPR 16 2 K7EQZ1;A0A669KB29 K7EQZ1 CXXC1 1 ARLS(0.984)PVT(0.007)PS(0.009)ES(0.001)LPRPR 78.848 0.028925 3612200.0 24268.0 26144.0 25729.0 31604.0 26581.0 30505.0 24654.0 25407.0 19212.0 23097.0 True False 22919.28171250116 28149.160733790362 24073.6241516171 27299.4806800591 23241.657142844982 34706.786853181 25800.459850974203 25480.930163644713 23054.936828130998 22430.129596787043 1.0218078149572611 1.2549709359602867 1.0732717369170026 1.2170897436085057 1.0361802432998062 1.5473288597562318 1.1502590629110736 1.1360135060162415 1.0278557120523037 1.0 14.45315033560011 -8.164468381723601 2.3077513631083986 1.0030259358991598 1.1922737398043473 0.18846395783979164 0.14133817502401602 0.5159310694506838 4.899002494526752 0.12488980218366642 0.03789401030013176 6.847493336107523e-09 8.164468381723601 0.18924780390518747 ARLT(ph)S(ph)T(ph)LPALT(ph)ALQK ddPTM_A459_Selumetinib_30min_R2 1 ARLTSTLPALTALQK 15 1 Q8WV28-3;Q8WV28-2;Q8WV28 Q8WV28-3 BLNK B-cell linker protein 4 ARLT(1)S(1)T(1)LPALT(1)ALQK 80.411 0.042083 1416000.0 4284.0 3035.8 3653.2 3599.3 3258.3 2273.6 2863.9 3128.5 2894.3 3575.2 True False 4045.9124302107743 3268.6360983644718 3418.1570893034154 3109.0691308611804 2848.9632244284176 2586.7677623141226 2997.0770247101923 3137.6034170489424 3473.2408734988308 3471.974686514829 1.1653058548857291 0.9414343114481435 0.9844994269628631 0.8954757484081967 0.8205599065839415 0.7450422298184213 0.8632197222954585 0.90369420872664 1.0003646878500927 1.0 11.76154071407678 -2.807434597653462 0.9090818121416683 0.8804244236003731 11.356426305317186 0.5108240678702687 0.07687562428464711 56.68746580617154 1.6307403238072138 0.02704579494000121 1148.3354993568862 0.0015579926422392644 2.807434597653462 10.476001881716812 ARPAPSRDPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 ARPAPSRDPSPPR 13 2 Q5C9Z4 Q5C9Z4 NOM1 Nucleolar MIF4G domain-containing protein 1 1 ARPAPSRDPS(1)PPR 89.506 0.025285 21910000.0 1696.7 3394.4 2173.8 2212.3 2487.8 2372.5 2670.3 2265.3 994.94 1747.5 True False 1736.2298087965105 2996.982069986252 1878.6098998286816 1825.9633350142649 2262.778929256764 2348.6348040576463 2468.8771211291355 2205.2168852685772 1688.3405124575183 1971.8086470914538 0.8805265213526487 1.5199152688608988 0.952734385560056 0.9260347537818538 1.1475651720031304 1.1911068589348341 1.2520875820130366 1.1183726618307592 0.8562395316340308 1.0 10.945303837753668 -8.221068480480875 9.840694560907796 0.9282865393893072 1.1319211297477603 0.1603938965165136 0.1780273280017075 0.882950081497497 212.96300698805564 0.11941652709132476 0.044666162597234965 6.010789505984872e-09 8.221068480480875 0.2036345903584531 ARPATDS(ph)FDDYPPR ddPTM_A459_Selumetinib_30min_R1 3 ARPATDSFDDYPPR 14 1 E7EX17;P23588;P23588-2;F8VP89;F8W0K0;F8VSC7 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 ARPAT(0.408)DS(0.592)FDDYPPR;ARPAT(0.001)DS(0.969)FDDY(0.03)PPR;ARPAT(0.006)DS(0.994)FDDYPPR 154.81 0.0015997 14987100.0 3371.59 3665.99 3790.4 4766.0 4039.78 3378.39 3820.9300000000003 2975.46 1641.13 3455.83 True False 3450.141487027892 3236.7741865274884 3275.6844991768507 3933.707568900234 3674.3826122810874 3344.4064639326903 3532.7141738516084 2896.541135143793 2784.8777466072374 3899.419443134798 0.8847833728433879 0.8300656632940724 0.8400441519426497 1.0087931360720384 0.9422896576950952 0.8576677920147198 0.9059590088650761 0.7428134309181222 0.7141775300705879 1.0 11.929043632006985 -7.7451961797381195 24.973885863132832 0.7963716080746137 0.8956795837577151 0.12574705637894634 0.08667515790355235 355.7202591346853 546921.0187357217 0.040724918544746545 0.023420346622670143 1.7980585116901162e-08 7.7451961797381195 0.09930797568310135 ARPATDS(ph)FDDYPPR ddPTM_A459_Selumetinib_30min_R2 3 ARPATDSFDDYPPR 14 1 E7EX17;P23588;P23588-2;F8VP89;F8W0K0;F8VSC7 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 ARPAT(0.017)DS(0.983)FDDYPPR;ARPAT(0.001)DS(0.999)FDDYPPR;ARPATDS(1)FDDYPPR 124.29 0.0035666 5727900.0 55446.0 67099.0 64570.0 71325.0 66431.0 45759.9 58980.6 49779.0 48636.0 60932.0 True False 52364.53328792403 72245.27754270971 60415.6364985004 61610.41195751212 58085.34387932482 52062.91085798643 61723.314767841686 49923.84864864295 58364.55900338225 59172.73483965136 0.8849436050205138 1.2209217258334069 1.0210046343508898 1.0411959515555005 0.9816234459456167 0.8798462839189127 1.0431039723802185 0.8436968273298265 0.9863420908555411 1.0 15.852644954516098 -6.3140035346514285 2.8399725156957003 0.9454148363863775 1.0560093493293004 0.16887287191179812 0.09318829682247136 0.40399725979203677 6.455599276247834 0.028885753512856587 0.03490612921233112 4.852845504948298e-07 6.3140035346514285 0.11059451294292288 ARPFPDGLAEDIDKGEVSAR ddPTM_A459_Selumetinib_30min_R2 2 ARPFPDGLAEDIDKGEVSAR 20 2 P13639 P13639 EEF2 Elongation factor 2 0 ; 113.14 0.00019682 14366300.0 53990.0 48631.0 51323.0 52897.0 53534.0 41595.0 44375.0 50227.0 37617.0 57056.0 False True 50989.45193909422 52360.84132668911 48020.93405625731 45692.33734758532 46808.58031996777 47324.33368818435 46438.52542739438 50373.152254472545 45141.45110679802 55408.645030708794 0.9202436174144784 0.9449940762433278 0.8666686223718874 0.8246427488393109 0.8447883952770427 0.8540965703448636 0.8381097462617438 0.909120810056888 0.8147005053413515 1.0 15.757823467194127 -4.415333470301413 0.0036830062059852813 1.7344508586926985 1.052349257397347e-06 0.04785597798057095 0.05539936367383813 344516.89308707125 178.0476850497403 40683.29569503719 43193.619134960056 3.8429658899670665e-05 4.415333470301413 -1.7344498063434413 ARPSAWEPAAGNS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 1 ARPSAWEPAAGNSPAR 16 1 Q8IY33;Q8IY33-4;Q8IY33-2;Q8IY33-5 Q8IY33 MICALL2 MICAL-like protein 2 1 ARPSAWEPAAGNS(1)PAR 117.13 0.008857700000000001 5037500.0 595.18 675.8 968.35 974.02 750.38 754.74 810.9 731.84 435.4 652.26 True False 609.0465359813205 596.6770218291039 836.8533887658042 803.9256916198506 682.5082614903487 747.148000849091 749.7331601406644 712.4292258486536 738.841999642192 735.9839245504267 0.8275269549580918 0.8107201827724458 1.1370538959488732 1.092314199812076 0.9273412621169091 1.0151689132415276 1.0186814346504054 0.9679956342576893 1.0038833390192745 1.0 9.523530444882205 -5.2394274415453985 24.687054784014276 1.0181720521513977 0.8191234943730866 0.6755608376459679 0.05575192189950223 415.16656358066405 465619.8537747461 0.015043809810658663 0.03972406456541758 5.761990772599829e-06 5.2394274415453985 -0.1990485577783111 ARPSQFPEQSSSAQQNGS(ph)VSDISPVQAAK ddPTM_A459_Selumetinib_30min_R1 1 ARPSQFPEQSSSAQQNGSVSDISPVQAAK 29 1 O00139-1;O00139-5;O00139;O00139-4 O00139-1 KIF2A Kinesin-like protein KIF2A 1 ARPSQFPEQSSSAQQNGS(0.682)VS(0.189)DIS(0.128)PVQAAK 107.47 7.451100000000002e-11 8426000.0 934.01 847.64 1092.8 893.6 813.88 531.59 815.48 719.65 457.15 765.03 True False 955.7706157329096 748.397914742855 944.4037623207215 737.5495349494862 740.2646977021849 526.2426872451017 753.967687053285 700.5625442473543 775.7501610850447 863.2290525232465 1.1072039488698406 0.8669748921856414 1.0940361188727357 0.85440768332994 0.8575530394144719 0.6096211494583937 0.8734271452627932 0.8115604336990132 0.8986608581088668 1.0 9.753599610237686 -5.883004893972984 6.374416432509178 0.825409132586871 1.0062895563279102 0.3447973505082066 0.11108399102618001 0.22909388671281541 11.874847181274335 0.0305170668564055 0.04570485082813711 1.3091671701873646e-06 5.883004893972984 0.1808804237410392 ARPSQFPEQSSSAQQNGSVS(ph)DISPVQAAK ddPTM_A459_Selumetinib_30min_R2 1 ARPSQFPEQSSSAQQNGSVSDISPVQAAK 29 1 O00139-1;O00139-5;O00139;O00139-4 O00139-1 KIF2A Kinesin-like protein KIF2A 1 ARPSQFPEQSSSAQQNGS(0.051)VS(0.657)DIS(0.292)PVQAAK 133.72 4.9159e-14 10335000.0 34382.0 28367.0 28940.0 40436.0 36739.0 30723.0 33009.0 39020.0 26742.0 38654.0 True False 32471.18608205107 30542.65768571876 27078.03190748956 34928.547044009276 32123.518369172783 34954.81437437401 34543.98390609262 39133.541739891254 32091.147233910007 37537.95858484681 0.8650226945255068 0.8136472743099065 0.7213506788411324 0.9304860562691628 0.8557609305408603 0.9311858101011503 0.9202414091861992 1.0425058584749076 0.8548985731702642 1.0 15.196062574214807 -6.483081944397828 1.033429879789539 0.9596896342153725 0.8089717361139521 0.4491858195579562 0.06503421080409978 0.4616739216764182 1.0550584414765005 0.03113891908505438 0.037706864631789655 3.287895877051289e-07 6.483081944397828 -0.15071789810142033 ARPSQFPEQSSSAQQNGSVSDIS(ph)PVQAAK ddPTM_A459_Selumetinib_30min_R1 1 ARPSQFPEQSSSAQQNGSVSDISPVQAAK 29 1 O00139-1;O00139-5;O00139;O00139-4 O00139-1 KIF2A Kinesin-like protein KIF2A 1 ARPSQFPEQSSSAQQNGS(0.268)VS(0.234)DIS(0.498)PVQAAK 125.2 7.009e-14 7002800.0 1934.8 2105.0 2039.6 2264.7 2391.2 1854.2 1794.0 2093.4 950.67 1851.3 True False 1979.8770755345606 1858.5456214120497 1762.633522720849 1869.2126586840882 2174.916382200649 1835.5484314788994 1658.6771356423133 2037.8762316784696 1613.2175558103884 2088.9323881890746 0.9477937566236619 0.8897107593909488 0.8437963491240141 0.8948172134496586 1.041161693168114 0.8787016955920544 0.794031029927323 0.9755587319152698 0.772268918291276 1.0 11.028550082570753 -9.937805349287599 13.413804521580685 0.9999999999491036 0.8950381739710102 0.14843759581181337 0.07669065341511722 0.0 0.0 0.07288231611028038 0.017676558091902456 1.153970351245615e-10 9.937805349287599 -0.10496182597809345 ARPSQFPEQSSSAQQNGSVSDIS(ph)PVQAAK ddPTM_A459_Selumetinib_30min_R2 1 ARPSQFPEQSSSAQQNGSVSDISPVQAAK 29 1 O00139-1;O00139-5;O00139;O00139-4 O00139-1 KIF2A Kinesin-like protein KIF2A 1 ARPSQFPEQSSSAQQNGS(0.005)VS(0.376)DIS(0.619)PVQAAK 152.93 4.89e-20 0.0 7030.8 6145.3 9008.8 7247.7 7556.3 7316.8 7882.2 7038.7 8211.5 6868.6 True False 6640.056282522382 6616.624749746094 8429.18361603981 6260.5507570201335 6607.010039820904 8324.622784702655 8248.737918282997 7059.181451680484 9854.029448479992 6670.285671233988 0.9954680518644093 0.9919552288863264 1.2636915465841556 0.9385731084980571 0.9905138048755597 1.2480159314020232 1.236639377209312 1.0583027173968924 1.4773024626180693 1.0 12.703532834324886 -6.7639175683442705 24.99766059181916 1.2097327363486965 1.0408236102439412 0.2527675863932912 0.14415395811322076 94.00903330031306 948267.0865631594 0.047867709748619376 0.04420093735911435 1.722195426821668e-07 6.7639175683442705 -0.16890912610475528 ARQEEGADAS(ph)EEDPTPAGEEDVK ddPTM_A459_Selumetinib_30min_R1 1 ARQEEGADASEEDPTPAGEEDVK 23 1 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 ARQEEGADAS(0.983)EEDPT(0.017)PAGEEDVK 94.606 0.0024357 0.0 1215.1 1272.2 713.6 473.59 638.69 885.78 1139.6 1015.5 701.43 1299.7 True False 1243.4094658269812 1123.2502325702653 616.6970395242196 390.8863968853258 580.9206022698784 876.869857423891 1053.6390545027768 988.5656411911174 1190.27547957975 1466.5291551500773 0.8478586746539907 0.7659242427098679 0.4205146807743552 0.26653844249371533 0.39611936812154946 0.5979218717504163 0.7184576254775874 0.6740852288681247 0.8116275598066396 1.0 10.518190037360997 -8.239157551991678 0.9319425723718704 0.9876882107819427 0.5396305996053692 0.4227760994478138 0.16529641375813445 0.5860120965849949 1.0572678715663513 0.17816749455783049 0.06395875587452479 5.765572638101138e-09 8.239157551991678 -0.4480576111765735 ARQEEGADAS(ph)EEDPTPAGEEDVK ddPTM_A459_Selumetinib_30min_R2 2 ARQEEGADASEEDPTPAGEEDVK 23 1 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 ARQEEGADAS(0.992)EEDPT(0.008)PAGEEDVK;ARQEEGADAS(1)EEDPTPAGEEDVK 103.42 1.6020999999999998e-05 33049000.0 97997.0 71904.0 84484.0 94863.0 86347.0 85789.0 125104.0 121478.0 84707.0 78450.0 True False 92550.71905307315 77418.80559219932 79048.39141922412 81942.49575219722 75499.31790802577 97605.65603499557 130921.58388887305 121831.48086823439 101650.76691133103 76184.9446624213 1.2148163848273341 1.0161956005250816 1.037585467437049 1.0755733447768174 0.9910004954727791 1.281167249874504 1.7184705517473577 1.5991542870848672 1.3342631849606226 1.0 16.217218306311956 -6.976025036625812 5.325039177368534 1.468769843815891 1.0667139405965362 0.4231214947216433 0.18683406877864364 0.1441496379045333 11.615388007008313 0.06576001293081352 0.0562304560954184 1.0567565865379731e-07 6.976025036625812 -0.4020559032193547 ARQEEGADAS(ph)EEDPTPAGEEDVKDAR ddPTM_A459_Selumetinib_30min_R1 2 ARQEEGADASEEDPTPAGEEDVKDAR 26 2 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 ARQEEGADAS(0.977)EEDPT(0.023)PAGEEDVKDAR;ARQEEGADAS(0.792)EEDPT(0.208)PAGEEDVKDAR 105.69 3.9276e-08 37527000.0 2634.6 2630.1 3030.4 3166.1000000000004 2854.0 2980.9 2813.9 2794.0 1728.28 2175.4 True False 2695.9810539607993 2322.1666692996823 2618.8883247956765 2613.200070057707 2595.856203914624 2950.914852440649 2601.6452575161125 2719.8940438089453 2932.764931423078 2454.6337801904124 1.0983231289808393 0.9460338597310209 1.066916110228273 1.0645987565016701 1.057532991220082 1.2021813095930503 1.0598914096726462 1.1080651076177872 1.1947871634014486 1.0 11.261292081945685 -6.15244250798254 1.5961224605782294 1.114900429390869 1.027436145464126 0.17489380254054454 0.0672990743628126 0.5651717284988482 2.868665634210916 0.022901697228835095 0.033991055859532486 7.039754142183442e-07 6.15244250798254 -0.08746428392674299 ARQEEGADAS(ph)EEDPTPAGEEDVKDAR ddPTM_A459_Selumetinib_30min_R2 1 ARQEEGADASEEDPTPAGEEDVKDAR 26 2 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 ARQEEGADAS(1)EEDPTPAGEEDVKDAR 161.04 4.3263999999999996e-14 13150000.0 48015.0 52062.0 52140.0 53721.0 47461.0 30836.0 30250.0 29172.0 23604.0 52644.0 True False 45346.518519274076 56054.9879942853 48785.36916573965 46404.107126106 41498.524873276605 35083.37909866215 31656.68493923785 29256.885690315405 28325.45955086426 51124.03093446148 0.8869902801171157 1.09645086605446 0.9542551374378151 0.9076770019483363 0.8117224740450473 0.6862404716020405 0.6192133984861283 0.5722726701230055 0.5540537205913227 1.0 15.64171397130952 -6.421075915959905 1.4898930411723148 0.6492717261539027 0.9897080252177708 0.5023718844036245 0.1277897773948176 0.2825039690719801 1.2678668542224965 0.04799409147299615 0.05771253558195177 3.7924868538729783e-07 6.421075915959905 0.3404362990638681 ARQEEGADASEEDPT(ph)PAGEEDVKDAR ddPTM_A459_Selumetinib_30min_R2 1 ARQEEGADASEEDPTPAGEEDVKDAR 26 2 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 ARQEEGADAS(0.292)EEDPT(0.708)PAGEEDVKDAR 102.29 3.4059e-06 22070000.0 48383.0 50712.0 54965.0 58372.0 55667.0 35856.0 33578.0 38057.0 23388.0 51014.0 True False 45694.06655249484 54601.447335219455 51428.61174136707 50421.63290268347 48673.61379070583 40794.838531639325 35139.443533544734 38167.739569324476 28066.25351532002 49541.09326971012 0.9223467537086553 1.1021445779962888 1.0381000568837062 1.0177739241275832 0.982489698515905 0.8234545473097514 0.7092989115569097 0.7704258636670132 0.5665247103555541 1.0 15.596338085787856 -6.81430298669479 2.41448015751488 0.742308103872657 1.0263311599557696 0.5540135261216519 0.10786417663646794 0.19470219263795296 2.3234426908775347 0.039644820415500465 0.0354691673031899 1.5335467265763732e-07 6.81430298669479 0.2840230560831126 ARQEELYSELQAR ddPTM_A459_Selumetinib_30min_R1 1 ARQEELYSELQAR 13 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 123.95 0.0066357 7099400.0 1797.6 1844.6 1907.5 1880.7 1599.8 1824.2 1827.7 2011.7 954.97 1581.0 False True 1839.480582479287 1628.6333744687242 1648.4719771474886 1552.2710501113459 1455.0983724676298 1805.850204241078 1689.835117510287 1958.3431810774698 1620.5143417508145 1783.936750244112 1.0311355389856587 0.9129434517484231 0.9240641390015164 0.8701379406522876 0.8156670197351535 1.0122837617387317 0.9472505778464689 1.0977649184083977 0.9083922630827943 1.0 10.800848749849239 -6.811590380568563 24.999558895696822 0.996380760763154 0.9093877145601225 0.26825270635532195 0.06787874786408264 145.14551493237238 72351.84352293251 0.02383152207073856 0.021017459433376372 1.5431552454880756e-07 6.811590380568563 -0.0869930462030315 ARQEELYSELQAR ddPTM_A459_Selumetinib_30min_R2 1 ARQEELYSELQAR 13 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 92.039 0.029664 0.0 4978.0 4008.4 4845.9 7005.8 6245.1 6881.4 4088.9 3636.4 3980.5 5360.1 False True 4701.342688512889 4315.831390962567 4534.120069816987 6051.597954320908 5460.5347060976355 7829.250386870332 4279.041952001639 3646.9813219615744 4776.711224462599 5205.339985787686 0.9031768724711782 0.8291161389546554 0.871051666595582 1.1625749654861717 1.0490255624045146 1.504080503530374 0.8220485047441379 0.7006230778237444 0.9176559528300963 1.0 12.345776680615444 ARQPLSEASNQQPLS(ph)GGEEK ddPTM_A459_Selumetinib_30min_R1 4 ARQPLSEASNQQPLSGGEEK 20 1 Q9NQW6;Q9NQW6-2;C9JJT6 Q9NQW6 ANLN Actin-binding protein anillin 1 ARQPLSEASNQQPLS(1)GGEEK;ARQPLSEAS(0.003)NQQPLS(0.997)GGEEK;ARQPLSEAS(0.002)NQQPLS(0.998)GGEEK;ARQPLSEASNQQPLS(1)GGEEK 100.44 0.00041741 50327000.0 11703.2 12650.0 17351.199999999997 18361.3 14004.5 13723.5 12437.300000000001 12686.400000000001 7779.5 11019.6 True False 11975.86178953693 11168.932119174555 14995.002343319265 15154.843639288267 12737.795447695295 13585.454049941025 11499.144447672326 12349.915460765129 13201.243307800725 12434.0729999937 0.9631487437417328 0.8982520948027419 1.2059606167123889 1.2188157202628573 1.024426625748598 1.0925988652268577 0.9248091472261867 0.9932316997633347 1.0616990352081264 1.0 13.602011333572811 -7.235407424732956 24.451096588129406 0.9943709211873483 1.070775597085052 0.11747889320891958 0.09673063357094128 1377.9243883562938 1294248.452817143 0.04064063229221314 0.031469025780148534 5.815573852822783e-08 7.235407424732956 0.07640467589770383 ARQPLSEASNQQPLS(ph)GGEEK ddPTM_A459_Selumetinib_30min_R2 3 ARQPLSEASNQQPLSGGEEK 20 1 Q9NQW6;Q9NQW6-2;C9JJT6 Q9NQW6 ANLN Actin-binding protein anillin 1 ARQPLSEASNQQPLS(1)GGEEK;ARQPLSEASNQQPLS(1)GGEEK;ARQPLSEASNQQPLS(1)GGEEK 144.73 1.6612e-05 51943900.0 139181.6 136263.0 147807.0 136396.0 127987.8 93170.5 99989.1 101660.3 83310.2 121856.0 True False 131446.4438600897 146713.93394539764 138297.25854009372 117818.62950377587 111908.82833855056 106003.89065741014 104638.79127464279 101956.11464223127 99974.56788147842 118337.70066008951 1.110774023213899 1.2397903045861554 1.1686660951553858 0.9956136450732247 0.9456735065352918 0.8957744663460487 0.8842388409692432 0.8615691708856814 0.844824323303721 1.0 16.85255024287708 -5.9487918148206 1.8589492967260852 0.8927067126651794 1.188072563728432 0.8449266774197689 0.05110426623512035 0.11623225374101893 0.813199677588794 0.016175699740222985 0.027454920768500177 1.1251441984397317e-06 5.9487918148206 0.2953658510632525 ARQPQS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 ARQPQSPPR 9 1 O95613-2;O95613 O95613-2 PCNT Pericentrin 1 ARQPQS(1)PPR 66.32600000000001 0.047066 3600700.0 3838.6 3915.4 3703.8 4393.4 4039.2 2991.4 2912.7 4362.2 2275.7 4029.0 True False 3625.2659791333044 4215.698590004698 3465.50154039253 3795.011340962268 3531.7595850938405 3403.4381967744807 3048.146321405557 4374.893279798913 2730.90358837069 3912.672301400833 0.9265447499488699 1.077447397906381 0.8857121868222378 0.9699282353913362 0.9026464045632914 0.8698500499405396 0.7790446238787352 1.1181343447118208 0.6979637899634373 1.0 11.933938569717732 -5.6904237143939795 1.3359267852387025 0.8955104993494194 0.9953767909316293 0.08089794342497159 0.11586710619510389 1.167413596370748 4.075251804662745 0.03672817381225086 0.10008188716411842 2.039746918050464e-06 5.6904237143939795 0.09986629158220994 ARQPS(ph)PFVDDCK ddPTM_A459_Selumetinib_30min_R1 1 ARQPSPFVDDCK 12 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 ARQPS(1)PFVDDCK 116.79 0.023385 8664500.0 1850.7 2132.5 2024.9 2136.3 1714.8 1734.2 1746.8 1786.7 1045.6 1814.4 True False 1893.8177091646726 1882.8259086276462 1749.929701979529 1763.2353083175774 1559.69664277253 1716.7555225276153 1615.037469643251 1739.310911980472 1774.3068323975117 2047.2959137526364 0.9250336975925271 0.9196647616887383 0.8547517191942989 0.8612508316326467 0.7618325383718709 0.8385478186105741 0.7888637195992504 0.8495649799800379 0.8666587084351948 1.0 10.999503927545735 -5.3103881272911115 2.34299848135506 0.8393585252775558 0.9280686176603353 0.1558990412986313 0.05974783106029744 0.453921964897174 4.711319255621269 0.01575979531624051 0.05035754126735788 4.89341301473657e-06 5.3103881272911115 0.08871009238277949 ARQPS(ph)PFVDDCK ddPTM_A459_Selumetinib_30min_R2 1 ARQPSPFVDDCK 12 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 ARQPS(1)PFVDDCK 118.08 0.02188 7303000.0 27322.0 22412.0 23344.0 28496.0 26625.0 19573.0 23069.0 23153.0 14975.0 26707.0 True False 25803.552618631835 24130.92833406172 21842.07245502545 24614.795641658126 23280.129469479973 22269.003083996435 24141.7542103563 23220.371396814506 17970.4184364596 25935.89951688063 0.9948971541101687 0.9304064552824116 0.842155963814146 0.9490627315870556 0.8976025471693349 0.8586169556025015 0.9308238642212276 0.8952984793028407 0.6928781639041816 1.0 14.66266278611367 -4.919731744222825 3.3666916421187336 0.8831445037031166 0.9958770326663763 0.16826630328509795 0.0769899676718806 0.4616723047603212 9.461261312567702 0.01900405004803467 0.11138983800323587 1.2030072808193712e-05 4.919731744222825 0.11273252896325969 ARS(ph)APPMEGAR ddPTM_A459_Selumetinib_30min_R1 2 ARSAPPMEGAR 11 1 Q86YD1 Q86YD1 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 ARS(1)APPMEGAR;ARS(1)APPMEGAR 144.51 0.003566300000000001 24971000.0 3011.54 3950.8 5008.0 6063.9 4651.1 4223.3 3701.8 3282.3 1823.9 2558.98 True False 3081.703022563236 3488.238499322911 4327.941106974901 5004.953698500655 4230.408826218402 4180.8174364495935 3422.5702456637205 3195.242741587005 3095.025087614597 2887.4500095760154 1.0672749354423436 1.2080688800687198 1.498880012683026 1.7333473071056105 1.4651020146456433 1.447927210024146 1.185326233982586 1.1065967310222578 1.071888717501662 1.0 11.49558025402677 -7.457570039810957 2.640825909189749 1.066235508562727 1.4171647842105768 0.4620243619420975 0.16838462610886093 0.2965523396547977 4.068623590945488 0.09788255636168032 0.056705959950297834 3.486823466833494e-08 7.457570039810957 0.3509292756478497 ARS(ph)APPMEGAR ddPTM_A459_Selumetinib_30min_R2 2 ARSAPPMEGAR 11 1 Q86YD1 Q86YD1 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 ARS(1)APPMEGAR;ARS(1)APPMEGAR 103.31 0.0073775 13273300.0 9640.099999999999 11748.0 11493.3 13757.5 12341.5 9255.5 6031.0 7515.5 6611.9 14232.599999999999 True False 9104.341834377885 12649.033824226179 10753.833590958871 11883.704766988762 10791.050435590134 10530.361111936294 6311.453450199788 7537.368860742002 7934.464751921683 13821.667857264209 0.6587006668368858 0.9151597299871641 0.7780416735529507 0.8597880436508306 0.7807343185373042 0.7618734020150749 0.4566347213214719 0.5453299079807226 0.5740598626635057 1.0 13.754644095436243 -7.067492465436223 8.280175912858788 0.6059003211514844 0.8037769082570068 0.17904385324249183 0.14834813731642424 0.4374298546336709 49.854045768028314 0.05318127424608623 0.04127024932852818 8.560665634680171e-08 7.067492465436223 0.19787658710552236 ARS(ph)DPTHQHR ddPTM_A459_Selumetinib_30min_R2 1 ARSDPTHQHR 10 1 A0A2R8Y6L5;A0A2R8Y6I6;Q13627-5;Q13627-2;Q13627 A0A2R8Y6L5 DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1 ARS(0.571)DPT(0.429)HQHR 81.494 0.01925 517870.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1011.8 0.0 1039.4 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1014.7441704874927 0.0 1009.3898213144768 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0053045404857 0.0 1.0 9.979267728349674 -8.419926866261935 0.601156867341316 0.9633807072271263 1.1702889586951266e-33 0.5211003056449436 0.27754570564860903 0.6428075790274977 0.5546731896005902 0.27250223157421605 0.12196467301327485 3.802534243340922e-09 8.419926866261935 -0.9633807072271263 ARS(ph)MDSSDLSDGAVTLQEYLELKK ddPTM_A459_Selumetinib_30min_R1 2 ARSMDSSDLSDGAVTLQEYLELKK 24 2 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QLH1 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 ARS(0.605)MDS(0.251)S(0.139)DLS(0.005)DGAVT(0.001)LQEYLELKK;ARS(0.695)MDS(0.247)S(0.055)DLS(0.004)DGAVTLQEYLELKK 93.062 1.0377e-05 36448000.0 4259.6 4361.2 8157.9 8061.799999999999 6136.5 5965.299999999999 4958.6 4947.8 2867.89 3729.1 True False 4358.84039226122 3850.5886765331243 7050.10198813709 6653.957968728473 5581.454658487072 5905.294498059037 4584.568809808236 4816.568271280561 4866.599867601852 4207.766309510007 1.0359036295361197 0.9151146697073879 1.6754975133013204 1.5813515959025122 1.3264649811640872 1.4034273920375362 1.089549293516281 1.1446853073552579 1.15657560558979 1.0 12.038838867269256 -7.269889705477989 23.910827625677502 1.109759633175351 1.3323503693912095 0.20685661065417882 0.2150980345917786 666.933503803227 1887125.94469018 0.09855062087423791 0.06773954152152933 5.371681996396981e-08 7.269889705477989 0.22259073621585856 ARS(ph)PDLGPQEQMNPK ddPTM_A459_Selumetinib_30min_R2 3 ARSPDLGPQEQMNPK 15 1 H3BUW4;H3BMU4;A0A0C4DGM2;C9K0J8;Q8IWY8-4;Q8IWY8-3;Q8IWY8-2;Q8IWY8 H3BUW4 ZSCAN29 Zinc finger and SCAN domain-containing protein 29 1 ARS(1)PDLGPQEQMNPK;ARS(1)PDLGPQEQMNPK;ARS(1)PDLGPQEQMNPK 159.5 7.536600000000001e-05 25867200.0 106284.0 113672.0 113439.0 130238.0 138835.0 96609.0 101751.0 105125.0 78983.0 101528.0 True False 100377.16076856253 122390.27688691179 106140.45824304475 112499.35972691848 121393.30609935231 109916.01282081497 106482.62311578162 105430.89634561935 94781.80696940818 98596.6228385761 1.018058812550827 1.2413232153731169 1.0765121074868813 1.1410062179422125 1.2312116034450722 1.1148050476411464 1.0799824583253383 1.0693154928666513 0.9613088586673643 1.0 16.589250611370893 -7.817874530885433 1.4395728255532307 0.9830988567884522 1.142920087348341 0.46380582472347864 0.06404221270402215 0.3624593592275125 1.3798671505247244 0.051103443842441 0.019070937596038413 1.5209868844136107e-08 7.817874530885433 0.15982123055988873 ARS(ph)PEICK ddPTM_A459_Selumetinib_30min_R2 1 ARSPEICK 8 1 Q1MSJ5;Q1MSJ5-1 Q1MSJ5 CSPP1 Centrosome and spindle pole-associated protein 1 1 ARS(1)PEICK 80.165 0.02574 13646000.0 47080.0 46191.0 52714.0 49231.0 46450.0 37115.0 41609.0 36943.0 33952.0 48504.0 True False 44463.482076172535 49733.70117252565 49322.43863066363 42525.65287178806 40614.53573173125 42227.25435357524 43543.900946669324 37050.49801375712 40743.34869814201 47103.5634914733 0.9439515565360851 1.055837339812485 1.0471063115976775 0.9028117985062014 0.8622391326949882 0.896476852780347 0.924429018083773 0.7865752666560781 0.8649738083089483 1.0 15.523548586670024 -5.836953590221679 5.477218810958271 0.8810851225857054 1.0193566941347265 0.48746849398655145 0.058118679174481616 0.15148486810640568 7.909810782710596 0.016198916345617577 0.024632345214176163 1.4556146228358432e-06 5.836953590221679 0.13827157154902114 ARS(ph)PPQPLGELKR ddPTM_A459_Selumetinib_30min_R2 1 ARSPPQPLGELKR 13 2 A0A044PY82;Q96FF7 A0A044PY82 LOC113230 Uncharacterized protein LOC113230 1 ARS(1)PPQPLGELKR 54.023 0.045396 5263900.0 23758.0 28191.0 31061.0 30606.0 35764.0 23497.0 23211.0 26766.0 20534.0 28199.0 True False 22437.625470809424 30353.159051647952 29062.56907665975 26437.41000170511 31271.00658578335 26733.49846547102 24290.357491723953 26843.88462865017 24641.373767897257 27384.821600199077 0.8193453219591655 1.1083935288965803 1.0612655981826253 0.965403769565288 1.1419101808410548 0.9762159073286305 0.8870007570743996 0.9802468323713682 0.8998186706360769 1.0 14.741088861436936 -6.994608039089012 24.99969794759349 0.9389044371732008 1.0271072093280609 0.1441887736447326 0.08808510115762991 248.03903036423503 1150017.9515907222 0.02984005442847849 0.026233538781059128 1.0124928404526164e-07 6.994608039089012 0.08820277215486005 ARS(ph)PPQVVK ddPTM_A459_Selumetinib_30min_R2 2 ARSPPQVVK 9 1 Q8IVE3-3;Q8IVE3 Q8IVE3-3 PLEKHH2 Pleckstrin homology domain-containing family H member 2 1 ARS(1)PPQVVK;ARS(1)PPQVVK 79.036 0.027476 4993800.0 52811.0 42770.0 62526.0 53768.0 66644.0 46335.0 40115.0 49042.0 37540.0 45551.0 True False 49875.97603918323 46050.3214727744 58503.145233161435 46444.705645026486 58271.58491508067 52717.22566274844 41980.426986364524 49184.70410065982 45049.04895523831 44235.82427428872 1.1275019027547033 1.0410187269764593 1.3225286561951854 1.0499342197636325 1.3172939776992012 1.1917315100962045 0.9490142362005197 1.1118749318580585 1.0183838482562708 1.0 15.432927585576309 -7.244804644629019 24.658058045528296 1.0291411642606774 1.1764001258575048 0.38337442874439864 0.09611586582626745 752.0300638683776 1114753.0449114835 0.03600632041031141 0.027805709994583913 5.691088711740903e-08 7.244804644629019 0.1472589615968274 ARS(ph)PSVAAMASPQLCR ddPTM_A459_Selumetinib_30min_R1 4 ARSPSVAAMASPQLCR 16 1 P25325-2 P25325-2 MPST 3-mercaptopyruvate sulfurtransferase 1 ARS(0.997)PS(0.002)VAAMAS(0.001)PQLCR;ARS(0.954)PS(0.046)VAAMASPQLCR;ARS(0.996)PS(0.004)VAAMASPQLCR;ARS(0.5)PS(0.5)VAAMASPQLCR 181.69 4.5329e-06 216094000.0 5441.0 6357.4 7099.6 7157.5 6950.6 5683.299999999999 5571.2 5761.9 3515.9800000000005 4866.200000000001 True False 5567.764713656991 5613.07265252492 6135.5133153113065 5907.576987915112 6321.919457228102 5626.1311620235265 5150.959898601148 5609.075694711079 5966.361262981068 5490.824170801962 1.0140125672324691 1.0222641406681763 1.117412090508661 1.075899865693984 1.1513607539730697 1.0246423828213391 0.9381032315680261 1.021536206629586 1.0866057767261652 1.0 12.422806998170902 -6.9793377963663215 24.99621277469367 1.008786943876996 1.076721389424338 0.2765999590674041 0.050415417417982986 324.359489412673 392394.5037826516 0.018743166945621895 0.016528638016938848 1.0487264068261291e-07 6.9793377963663215 0.06793444554734185 ARS(ph)PSVAAMASPQLCR ddPTM_A459_Selumetinib_30min_R2 2 ARSPSVAAMASPQLCR 16 1 P25325-2 P25325-2 MPST 3-mercaptopyruvate sulfurtransferase 1 ARS(0.991)PS(0.009)VAAMASPQLCR;ARS(1)PSVAAMASPQLCR 117.27 0.0010199 393660000.0 63677.0 47329.0 56963.0 63729.0 60926.0 44003.0 42255.9 53455.0 45042.0 46684.2 True False 60138.08725922768 50958.982113278915 53298.06259662504 55049.000261343026 53271.931194649274 50064.01383053675 44220.88307847738 53610.54520004835 54051.658578631905 45336.30584588152 1.3264884762261853 1.1240214914402464 1.1756154720194694 1.2142365645864337 1.1750390818286895 1.104280838423996 0.9753966992547659 1.1825080186792167 1.1922378228693309 1.0 15.46837921979102 -6.700368918922425 3.7555058899526443 1.094388603672582 1.2005036741246304 0.33709520744121624 0.07938195154270891 0.31339208453572925 8.899577686907813 0.028130767692722467 0.02727811782262853 1.9935681247357737e-07 6.700368918922425 0.10611507045204838 ARS(ph)PYSPAEEDALFMDLPTGPR ddPTM_A459_Selumetinib_30min_R1 1 ARSPYSPAEEDALFMDLPTGPR 22 1 E9PKC0;Q6IQ23;Q6IQ23-2;A0A1B0GTN9 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 ARS(0.538)PY(0.441)S(0.021)PAEEDALFMDLPTGPR 122.22 1.7884e-05 6739200.0 771.16 786.41 672.71 997.55 782.33 809.15 900.54 731.9 449.22 523.76 True False 789.1265275838491 694.3367516079094 581.3596769315266 823.3466188326544 711.5683896315794 801.0106856494176 832.6115427710864 712.4876344537456 762.2935302693287 590.9896978544318 1.3352627473012582 1.1748711595628072 0.9837052643085544 1.3931657722999005 1.2040284157488776 1.3553716563206768 1.408842735827468 1.2055838486532133 1.2898592531084885 1.0 9.206989171304663 -4.732192232823163 22.466836737750445 1.2374057097512456 1.335264687515818 0.04608538889963887 0.14038583729739912 3494.869974292043 2684140.986013302 0.03491024454295063 2.8660778781968825 1.8527113717510855e-05 4.732192232823163 0.09785897776457242 ARSDEGQLS(ph)PATR ddPTM_A459_Selumetinib_30min_R1 5 ARSDEGQLSPATR 13 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 ARSDEGQLS(0.999)PAT(0.001)R;ARSDEGQLS(0.999)PAT(0.001)R;ARSDEGQLS(1)PATR;ARSDEGQLS(1)PATR;ARSDEGQLS(0.992)PAT(0.008)R 207.08 5.4497e-05 122870000.0 11335.8 10752.7 21410.1 22479.2 16733.2 14115.800000000001 12405.199999999999 11591.5 7113.81 8447.17 True False 11599.902084372889 9493.768885205387 18502.72601726104 18553.62970684478 15219.685014486411 13973.807868120932 11469.465776516181 11284.055765501567 12071.615997874658 9531.446551903584 1.217013810149961 0.9960470148478489 1.9412295832016964 1.9465701880413229 1.596786482682085 1.46607419891896 1.2033289715321902 1.1838765190628866 1.266504085412278 1.0 13.218479467830532 -7.208426295733695 3.006940558026578 1.1710160921148145 1.5531087230650062 0.29466640080547124 0.2774399264228144 0.40445011973993655 7.273463472472354 0.13530767441773017 0.0963136406436208 6.188333410617809e-08 7.208426295733695 0.38209263095019175 ARSDEGQLS(ph)PATR ddPTM_A459_Selumetinib_30min_R2 2 ARSDEGQLSPATR 13 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 ARSDEGQLS(0.989)PAT(0.011)R;ARS(0.004)DEGQLS(0.996)PATR 111.88 0.019043 11404000.0 53288.0 62306.0 67412.0 68236.0 67814.0 36780.8 26276.4 42624.4 22775.8 59793.0 True False 50326.46628876558 67084.66985463364 63074.785312636 58942.1390863344 59294.59905514798 41847.02133714078 27498.30466569883 42748.429947150704 27331.5964090228 58066.620729128794 0.8667021716922403 1.1553052168744684 1.0862485972254088 1.015077825198228 1.0211477490957757 0.7206725793868776 0.47356474891097733 0.7361962761112805 0.47069376632954396 1.0 15.825421456311142 -6.803104892793106 3.9510590763758966 0.642226433898459 1.0415287022263808 0.5553490115365103 0.15544116057479657 0.14470417975031008 4.753309300518592 0.05236159100633412 0.047528925419643715 1.573602754817927e-07 6.803104892793106 0.3993022683279218 ARSDPT(ph)HQHR ddPTM_A459_Selumetinib_30min_R2 1 ARSDPTHQHR 10 1 A0A2R8Y6L5;A0A2R8Y6I6;Q13627-5;Q13627-2;Q13627 A0A2R8Y6L5 DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1 ARS(0.299)DPT(0.701)HQHR 67.456 0.046989 1096500.0 0.0 572.34 523.89 0.0 0.0 0.0 812.7 3165.1 742.17 641.26 True False 0.0 616.2366376368411 490.1834877683034 0.0 0.0 0.0 850.4921603344991 3174.309916989489 890.6247379624184 622.7451576064275 0.0 0.9895486622576041 0.7871333590972657 0.0 0.0 0.0 1.3657146104570865 5.097285588201459 1.430159234614699 1.0 9.282498088056405 -7.5289797951656645 24.99975995217563 2.8045338555778687 0.35301830584415644 0.4554400827562408 1.0721041466803602 122.82622761798376 503284.952479331 0.4723453633704739 0.27365019009016256 2.9581500864031025e-08 7.5289797951656645 -2.4515155497337124 ARSPY(ph)SPAEEDALFMDLPTGPR ddPTM_A459_Selumetinib_30min_R2 1 ARSPYSPAEEDALFMDLPTGPR 22 1 E9PKC0;Q6IQ23;Q6IQ23-2;A0A1B0GTN9 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 ARS(0.063)PY(0.818)S(0.12)PAEEDALFMDLPTGPR 138.82 0.00010321 3299500.0 12274.0 10416.0 13442.0 11402.0 12800.0 8221.4 9602.1 9756.0 8743.9 10202.0 True False 11591.860216714982 11214.873707281224 12577.156354543009 9849.027930452909 11191.949566548128 9353.823223561452 10048.616676200189 9784.388344807261 10492.924324978907 9907.441752020668 1.1700154799649232 1.1319646370864507 1.2694655865100433 0.9941040459252919 1.1296508066035795 0.9441209403682538 1.0142493822031027 0.9875796991500546 1.0590952324134357 1.0 13.274296864966075 -5.774570538147513 24.999995487377106 1.0192500262748483 1.184630180791883 0.6624217622834727 0.05624551608240129 131.34623720330575 250065.74492514128 0.01549757515090032 0.023141788518589456 1.680464962276674e-06 5.774570538147513 0.1653801545170348 ARSPYS(ph)PAEEDALFMDLPTGPR ddPTM_A459_Selumetinib_30min_R2 1 ARSPYSPAEEDALFMDLPTGPR 22 1 E9PKC0;Q6IQ23;Q6IQ23-2;A0A1B0GTN9 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 ARS(0.108)PY(0.346)S(0.546)PAEEDALFMDLPTGPR 90.884 0.00036546 2520300.0 7331.9 5798.4 6245.9 7636.6 9322.6 4929.1 5328.3 6860.2 3885.3 8075.3 True False 6924.422349921182 6243.118635205405 5844.045594021737 6596.481906130214 8151.4116428985535 5608.038783085214 5576.076507826148 6880.162046232753 4662.4685643523535 7842.145106850864 0.882975545029387 0.7960983315332234 0.7452100814758457 0.8411578485544161 1.039436472015484 0.7151154061388199 0.711039700471101 0.8773316423617656 0.594539950590718 1.0 12.937032621619538 ART(ph)SSFAEPGGGGGGGGGGPGGSASGPGGTGGGK ddPTM_A459_Selumetinib_30min_R1 1 ARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGK 34 1 P49840 P49840 GSK3A Glycogen synthase kinase-3 alpha 1 ART(0.383)S(0.347)S(0.27)FAEPGGGGGGGGGGPGGSASGPGGTGGGK 91.873 8.0318e-09 14598000.0 1642.5 1904.8 5961.0 5797.1 2947.5 2483.1 1880.3 1880.3 1570.6 1555.3 True False 1680.767054251351 1681.785130482505 5151.52894142919 4784.745310044386 2680.8991454233924 2458.1222684744093 1738.4674571617852 1830.4283359248238 2665.193487914623 1754.9379049049144 0.9577359116546166 0.9583160325969637 2.935447987664446 2.726447070674921 1.5276319110382701 1.400689028144044 0.990614797425541 1.0430160125944739 1.5186825017942887 1.0 10.777204269111804 -6.686869464857614 3.055367403917424 1.1653351052479717 1.916088548476001 0.21958243008562794 0.6171946390151247 0.4272780159510728 8.057707547245723 0.2457011967728214 0.23850255069832663 2.0565086243451959e-07 6.686869464857614 0.7507534432280294 ARTDEVPAGGS(ph)RSEAEDEDDEDYVPYVPLR ddPTM_A459_Selumetinib_30min_R1 1 ARTDEVPAGGSRSEAEDEDDEDYVPYVPLR 30 2 D6RGI7;A0A499FJW5;Q9UJV9;D6RD33 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 ART(0.013)DEVPAGGS(0.493)RS(0.493)EAEDEDDEDYVPYVPLR 87.196 7.6065e-07 8570700.0 631.27 801.64 948.79 951.39 554.92 551.9 755.5 428.22 436.63 305.43 True False 645.9773627624049 707.7836161276742 819.9495293304144 785.2475963021388 504.72758397908297 546.3483870851067 698.5120267434601 416.8622145454066 740.9292198065468 344.63491564013884 1.8743816527194885 2.053719991815131 2.379182990810455 2.2784911239872145 1.464528290877265 1.5852960982502224 2.0268173508943965 1.2095762664415757 2.1498959803022712 1.0 8.428925061010009 -6.260179630948961 24.994706281070417 1.6065015770815987 2.156445031928091 0.400339661292074 0.3424269986364386 120.3221630630876 2387312.0423024083 0.09849104231837678 0.12019982349817523 5.493136222100568e-07 6.260179630948961 0.5499434548464923 ARTDEVPAGGS(ph)RSEAEDEDDEDYVPYVPLR ddPTM_A459_Selumetinib_30min_R2 2 ARTDEVPAGGSRSEAEDEDDEDYVPYVPLR 30 2 D6RGI7;A0A499FJW5;Q9UJV9;D6RD33 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 ART(0.005)DEVPAGGS(0.494)RS(0.494)EAEDEDDEDY(0.005)VPY(0.001)VPLR;ART(0.1)DEVPAGGS(0.448)RS(0.448)EAEDEDDEDY(0.003)VPYVPLR 47.646 0.027182 8127800.0 11713.6 24756.0 19227.6 19119.9 18507.2 11365.599999999999 8998.8 10186.9 8747.6 18780.4 True False 11062.605005256046 26654.70559691379 17990.517149428004 16515.73663633281 16182.160079532767 12931.108233355639 9417.262030783922 10216.542192467923 10497.36442836554 18238.161054660755 0.6065636207565456 1.4614798891745826 0.9864216625519124 0.9055593152639817 0.8872692828533512 0.7090138196828292 0.5163493184734952 0.5601739211452511 0.5755714294278009 1.0 14.154672650111909 -6.52059898342246 1.4763060116742992 0.625076797858012 1.0438657112597904 0.28916380459515145 0.2325462800520811 0.420664031385114 1.8777790835513377 0.09159337408149146 0.10152712772255582 3.015789442873043e-07 6.52059898342246 0.4187889134017785 ARVDHGAEIITQS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 ARVDHGAEIITQSPGR 16 1 A0A669KB77;P11137-2;P11137-4;P11137-3;P11137 A0A669KB77 MAP2 Microtubule-associated protein 2 1 ARVDHGAEIIT(0.196)QS(0.804)PGR 74.77600000000002 0.017534 5582800.0 27436.0 28402.0 32802.0 32482.0 34805.0 25834.0 22439.0 23308.0 23141.0 29161.0 True False 25911.21695500996 30580.342073176012 30691.555032117227 28057.895565424595 30432.48473935214 29392.399002297258 23482.45796203497 23375.822421152887 27769.846613563383 28319.046160622886 0.9149749185775555 1.0798507089443365 1.083777852475599 0.9907782700830716 1.0746295820396647 1.0379021537514512 0.8292107660987147 0.8254452600051388 0.980606707445424 1.0 14.789485053073689 -7.2444843113677635 24.35175078957199 0.8942694589316238 1.0352171444187788 0.40812966934817896 0.07067271676376836 492.9596580545933 708015.0288629646 0.026455276055942598 0.020433318998174698 5.695287976485268e-08 7.2444843113677635 0.14094768548715497 ARVGGS(ph)DEEASGIPSR ddPTM_A459_Selumetinib_30min_R1 2 ARVGGSDEEASGIPSR 16 1 H7C446;A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3 H7C446 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 1 ARVGGS(1)DEEASGIPSR;ARVGGS(1)DEEASGIPSR 118.66 0.0082812 13590200.0 3102.2 2717.4 5741.1 6130.8 4087.7 4069.8 3650.3 3365.5 2019.65 2163.3 True False 3174.4752241695846 2399.2455447150137 4961.490153604955 5060.1708693691935 3717.9682567420523 4028.861507082741 3374.95493212661 3276.2360073153172 3427.1985406002623 2440.9806273264326 1.3004917731143721 0.9829023294391604 2.0325807169716033 2.073007385933873 1.523145335575352 1.6505094149376716 1.382622579771616 1.3421802576547799 1.4040252930454507 1.0 11.253245129977389 -8.439908672327174 0.7832544487043708 1.0199227363612018 1.5964353242729314 0.23993749891430127 0.3058493147029343 1.0607350027759297 1.470825368713257 0.32583137186985844 0.12321716616837652 3.631544143876626e-09 8.439908672327174 0.5765125879117297 ARVS(ph)SGYVPPPVATPFSSK ddPTM_A459_Selumetinib_30min_R1 1 ARVSSGYVPPPVATPFSSK 19 1 Q15942;Q15942-2;H7C3R3 Q15942 ZYX Zyxin 1 ARVS(0.354)S(0.354)GY(0.293)VPPPVATPFSSK 84.249 0.0022331 36908000.0 1028.7 990.43 1354.3 1420.6 994.85 553.76 797.76 959.69 523.97 686.98 True False 1052.6667084982435 874.4699951615847 1170.3934986374027 1172.5188779646826 904.8659931550336 548.1896771738509 737.5843209197391 934.2359036875471 889.1388207453371 775.1605747518666 1.3579982558261663 1.128114643138949 1.5098723242110867 1.5126141810553415 1.1673271611429494 0.7071949929204404 0.9515245549682968 1.2052159695900444 1.147038239180257 1.0 9.598351385841976 -6.5195856662305145 24.97517928193563 1.0035657632838813 1.3652329340217542 0.5543278875164315 0.15834235131870358 113.7736169245964 862884.1081432067 0.056196832659288036 0.05730394410367066 3.0228342462020897e-07 6.5195856662305145 0.3616671707378729 ARVS(ph)SGYVPPPVATPFSSK ddPTM_A459_Selumetinib_30min_R2 1 ARVSSGYVPPPVATPFSSK 19 1 Q15942;Q15942-2;H7C3R3 Q15942 ZYX Zyxin 1 ARVS(0.499)S(0.499)GY(0.003)VPPPVATPFSSK 110.89 0.00035026 16212000.0 57347.0 58421.0 71014.0 73292.0 71714.0 70553.0 58792.0 51789.0 58034.0 95103.0 True False 54159.88331822994 62901.702846877546 66445.03655419711 63309.50316424792 62704.64618870571 80271.03533363302 61525.9444941379 51939.69741586952 69642.42160544217 92357.1292827308 0.5864180030155713 0.6810703552112146 0.7194359230329735 0.6854858272006265 0.678936717454149 0.8691374012708981 0.6661742842373316 0.5623788636486058 0.7540557198594533 1.0 16.494935710371166 -8.547753846954034 22.525535571475274 1.0000000030761538 0.6863683472634696 0.6023626506893431 0.07768740689278732 1316.6832419788686 1192315.696914664 0.0774019403252885 0.01998509508003854 2.8329972506291287e-09 8.547753846954034 -0.31363165581268415 ARVSS(ph)GYVPPPVATPFSSK ddPTM_A459_Selumetinib_30min_R1 1 ARVSSGYVPPPVATPFSSK 19 1 Q15942;Q15942-2;H7C3R3 Q15942 ZYX Zyxin 1 ARVS(0.375)S(0.625)GYVPPPVATPFSSK 133.48 0.0001242 35049000.0 2989.3 3398.3 4286.7 4459.2 3539.3 3633.5 2873.7 3041.2 2261.4 2189.5 True False 3058.9448738347432 3000.4254561731914 3704.589685157608 3680.4844295509693 3219.170939914166 3596.9502889540363 2656.9344953708573 2960.53749679018 3837.4306338788574 2470.543652536044 1.2381666969108998 1.2144798385137687 1.4995038364753441 1.489746771231063 1.3030212749366505 1.4559347232183983 1.0754452740163003 1.1983344207462803 1.5532737622100652 1.0 11.27061283194352 -7.246009578605456 24.95903103238998 1.2232912165884582 1.3686050474581073 0.185106640738827 0.1630138009165068 1557.4429412523507 2519301.202713235 0.06318047032463435 0.048758760096729435 5.675320880358181e-08 7.246009578605456 0.1453138308696491 ARVSS(ph)GYVPPPVATPFSSK ddPTM_A459_Selumetinib_30min_R2 1 ARVSSGYVPPPVATPFSSK 19 1 Q15942;Q15942-2;H7C3R3 Q15942 ZYX Zyxin 1 ARVS(0.404)S(0.581)GY(0.015)VPPPVATPFSSK 80.031 0.0036097 13640000.0 34424.0 40898.0 32288.0 36936.0 45390.0 32961.0 29926.0 34309.0 29444.0 46550.0 True False 32510.85189019039 44034.745092203106 30210.62523251636 31905.253081846033 39687.702408251505 37501.078559832735 31317.618297244033 34408.83350983931 35333.6227340979 45205.98054857499 0.7191714789873133 0.97409113922187 0.6682882411997294 0.7057750477851712 0.8779303518393113 0.8295601180365253 0.6927759981578643 0.7611566675976894 0.7816138994293247 1.0 15.46422602690265 -11.41228509129689 2.311845718283272 1.121768515638237 0.780607829533335 0.35638953385194816 0.08909974293575577 11842106.601417663 6012942.808886065 7862558.2263784185 0.02289768767715739 3.8700351423464415e-12 11.41228509129689 -0.34116068610490213 AS(ph)ASPDRIPSLPQETVDQEPK ddPTM_A459_Selumetinib_30min_R2 2 ASASPDRIPSLPQETVDQEPK 21 1 A0A494C1R1;A0A2R8Y5U1;Q76L82;Q8IXJ9 A0A494C1R1 ASXH1;ASXL1 Putative Polycomb group protein ASXL1 1 AS(0.511)AS(0.371)PDRIPS(0.11)LPQET(0.008)VDQEPK;AS(0.556)AS(0.439)PDRIPS(0.003)LPQET(0.003)VDQEPK 58.361 0.013869 27817000.0 118770.0 88964.0 81647.0 99752.0 98389.0 74527.0 82916.0 90952.0 68201.0 101519.0 True False 112169.23887398072 95787.2527356534 76393.9209105321 86165.60551820193 86028.49421117999 84792.41776125286 86771.75829493698 91216.6552620858 81843.10569515714 98587.88269196109 1.1377588787909638 0.9715925539748299 0.7748814440941565 0.8739979312409751 0.8726071791193342 0.8600693659908256 0.8801462809182776 0.925231912598156 0.8301538024797308 1.0 16.58912271728355 -4.88375758954823 3.395427155699359 0.8733967758532468 1.1457888444849098 0.6689669829384526 0.05597257311163455 0.1414878303201949 2.785210424171476 0.013375559455733776 0.08607657872540282 1.3069001579507516e-05 4.88375758954823 0.272392068631663 AS(ph)ASPSTSSTSSRPK ddPTM_A459_Selumetinib_30min_R1 1 ASASPSTSSTSSRPK 15 1 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;F5H858 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 AS(0.887)AS(0.109)PS(0.004)TSSTSSRPK 106.38 0.0024748 16693000.0 2773.0 2825.2 3829.6 3549.5 3132.2 2749.1 3208.9 3216.1 1610.6 2510.5 True False 2837.605504681276 2494.424270600154 3309.5613544870357 2929.646457367054 2848.8930630348227 2721.4465499830853 2966.8500894997896 3130.798580634914 2733.070566430215 2832.747129340826 1.0017150755498534 0.880567222101678 1.16832219869098 1.0342068400749826 1.0056997440847302 0.960709313512343 1.0473402510128635 1.105216398670729 0.9648127565365124 1.0 11.467986107158733 -5.227344506160937 24.999980240628425 1.0361463126053592 0.9411411722070537 0.2512022794395381 0.06536160955661618 863.8730148507394 633430.060914909 0.016393162929220065 0.04336842924328301 5.92455170250247e-06 5.227344506160937 -0.09500514039830543 AS(ph)DGQLQAK ddPTM_A459_Selumetinib_30min_R1 2 ASDGQLQAK 9 0 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 AS(1)DGQLQAK;AS(1)DGQLQAK 142.89 0.0020803 16312800.0 6643.299999999999 8523.1 5300.9 5840.4 6384.0 6122.1 7613.299999999999 7074.7 3966.5 6858.0 True False 6798.075964388429 7525.211489718304 4581.066895759434 4820.483777886052 5806.568327186741 6060.517232422049 7039.022651497001 6887.055974135695 6730.860798302148 7738.291102576926 0.8784983498649468 0.9724642546998956 0.591999814304465 0.6229390590230941 0.7503682984028731 0.7831854801125068 0.9096352874542207 0.8899970139198095 0.869812302106431 1.0 12.917799286426503 -7.209636178448771 3.662051029105304 0.9097440631995688 0.7582392880326702 0.318257872831501 0.10798040323301365 0.34511638584561916 9.506026497709259 0.04970945817796453 0.03628339673811909 6.171117584630005e-08 7.209636178448771 -0.15150477516689864 AS(ph)DGQLQAK ddPTM_A459_Selumetinib_30min_R2 4 ASDGQLQAK 9 0 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 AS(1)DGQLQAK;AS(1)DGQLQAK;AS(1)DGQLQAK;AS(1)DGQLQAK 138.42 0.0024679000000000003 27086500.0 154757.0 119005.0 129435.0 168988.0 180292.0 144567.0 176477.0 198608.0 175351.0 146126.0 True False 146156.225481356 128132.30083861409 121107.29301817245 145971.54287943983 157642.10712906971 164479.79200143632 184683.53018254132 199185.91639867553 210426.09971630195 141906.96269905628 1.029944004871073 0.902931740638729 0.8534274197313776 1.0286425704776965 1.1108835262959094 1.1590678066322264 1.3014409347496345 1.4036373734606058 1.482845490552532 1.0 17.114585851749048 -6.69238165763534 1.2210171869986866 1.3321272300009181 0.9320025426109896 0.5816915723020576 0.1285657617073004 0.2900063614114366 0.9128030568689907 0.06113586695621882 0.05883192422429086 2.030571761810593e-07 6.69238165763534 -0.40012468738992857 AS(ph)DKDITVSK ddPTM_A459_Selumetinib_30min_R2 1 ASDKDITVSK 10 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 AS(1)DKDITVSK 66.98899999999999 0.046278 33594000.0 108290.0 88175.0 108910.0 107650.0 104090.0 64002.0 99386.0 99120.0 84054.0 83207.0 True False 102271.67531921678 94937.73897268859 101902.84917224238 92987.88429339202 91013.28362359328 72817.6945476901 104007.64592962296 99408.42278980066 100867.14866498687 80804.59771225112 1.2656665364935162 1.174905162089492 1.2611021161830802 1.1507746703291084 1.1263379337360944 0.9011578129130381 1.2871500988099582 1.2302322591073174 1.2482847699357333 1.0 16.302149762971467 -5.846378659073273 6.612708717648605 1.1399862198266681 1.2276772866121557 0.1413033592338071 0.11124253677630473 0.5073231138696879 32.22403644378092 0.03294490915069583 0.04940477111668616 1.4243651555599684e-06 5.846378659073273 0.08769106678548755 AS(ph)DLEDEESAAR ddPTM_A459_Selumetinib_30min_R1 1 ASDLEDEESAAR 12 0 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 AS(1)DLEDEESAAR 184.96 0.00010448 18534000.0 1276.5 1127.1 1366.7 1248.0 1052.9 1099.2 1191.4 989.69 735.46 1165.7 True False 1306.2399663633794 995.1386080254258 1181.109646745727 1030.060227861413 957.6653809045931 1088.143045993747 1101.5317387983575 963.4402062338136 1248.0219041268876 1315.3289498795452 0.9930899540248102 0.7565701402045156 0.8979576149782839 0.7831198636323967 0.7280805162786799 0.8272782607676935 0.8374572299189744 0.7324709201618677 0.9488287353830224 1.0 10.361207932097502 -8.444118367629102 5.538498887490717 0.999226259889783 0.8170198110077694 0.40521595065547644 0.07618825482301973 0.18226557581036545 8.86865496671424 0.07004213057973496 0.01818610810599215 3.596512982817138e-09 8.444118367629102 -0.18220644888201354 AS(ph)DLEDEESAAR ddPTM_A459_Selumetinib_30min_R2 4 ASDLEDEESAAR 12 0 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 AS(1)DLEDEESAAR;AS(1)DLEDEESAAR;AS(1)DLEDEESAAR;AS(1)DLEDEESAAR 217.46 4.7800000000000005e-08 155079500.0 87472.0 66633.7 83200.0 90952.0 100548.0 86949.0 117897.0 114981.0 103169.0 74229.0 True False 82610.65641815981 71744.2905288849 77847.00258131066 78564.18069904855 87916.26132947509 98925.43550556408 123379.44410847344 115315.57567387064 123805.68278271118 72085.81589989639 1.1460043198079213 0.9952622389474546 1.0799212245778653 1.0898701737405385 1.219605552520374 1.3723287205757528 1.7115633993767527 1.599698556981116 1.7174763334112326 1.0 16.13742779235813 -6.767049029599886 2.0680407128845957 1.5558761436591126 1.0755374388059218 0.4864242802164016 0.19545912514262054 0.2319086243345977 2.0413105194380337 0.07360286378317946 0.06742213982170714 1.7098222741060215e-07 6.767049029599886 -0.48033870485319086 AS(ph)DPGLPAEEPK ddPTM_A459_Selumetinib_30min_R1 4 ASDPGLPAEEPK 12 0 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK 187.74 0.00010352 413941000.0 35056.3 44863.9 22051.5 22942.7 23058.9 30269.000000000004 31471.7 33374.600000000006 16953.7 31832.4 True False 35873.04358231453 39611.21373133875 19057.027420219056 18936.18813281734 20973.226566379457 29964.521342053053 29097.764330988954 32489.39719202076 28769.190650743778 35918.39861383348 0.9987372757898655 1.1028112404789403 0.530564506093529 0.5272002334069628 0.583913185881898 0.8342387884328626 0.8101075062901704 0.9045335662461275 0.8009597242919321 1.0 15.132435409935255 -8.357829347912922 0.8571980638984148 0.9819521303920018 0.7555354633979736 0.11545475542228556 0.18242754667776337 1.4249604906901867 2.3051242726600005 0.19559284842604724 0.07154643853850381 4.387030483043331e-09 8.357829347912922 -0.22641666699402818 AS(ph)DPGLPAEEPK ddPTM_A459_Selumetinib_30min_R2 5 ASDPGLPAEEPK 12 0 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK;AS(1)DPGLPAEEPK 187.62 0.00011807 681530000.0 638246.0 379068.0 472614.0 584002.0 514074.0 564712.0 793015.0 721902.0 580675.0 410078.8 True False 602774.8424211723 408141.29670427094 442206.5297832162 504459.920140358 449491.4282401294 642495.9520548608 829891.7688294109 724002.61530269 696826.2254151019 398238.759531321 1.5136016472393736 1.0248658296962456 1.1104055524470795 1.2667273289371594 1.1286983435995195 1.6133435952115787 2.0839050669153685 1.8180114264989016 1.749769977777106 1.0 18.603274116043572 -6.855910519191958 4.764367507358986 1.7449637605084563 1.1969342081157368 0.3595871339842116 0.2873815403108474 0.19005898878598101 7.367041336141644 0.09813574959086814 0.08689134132785842 1.3934438746096082e-07 6.855910519191958 -0.5480295523927194 AS(ph)DPGLPAEEPKEK ddPTM_A459_Selumetinib_30min_R1 3 ASDPGLPAEEPKEK 14 1 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 AS(1)DPGLPAEEPKEK;AS(1)DPGLPAEEPKEK;AS(1)DPGLPAEEPKEK 169.4 0.0008475 23821000.0 9027.0 10366.8 13319.3 12824.6 10186.3 10638.7 9823.1 10013.0 6316.05 7536.48 True False 9237.311536515652 9153.05023660543 11510.612217677872 10585.024357557273 9264.95096353733 10531.684337166731 9082.135658376814 9747.422713192187 10717.87554395974 8503.860619531784 1.08624916961824 1.0763405759006184 1.3535748917662336 1.2447316379157771 1.0894993906952641 1.2384591902855762 1.0680014718864088 1.1462350042290406 1.2603540936857287 1.0 13.053902235581177 -7.25635830362148 24.93649912535166 1.130833894031756 1.1832141362571396 0.07883561566464581 0.1017565346603746 1450.3119480233079 7117758.982874803 0.0409222697585871 0.030725266678161674 5.541683218187699e-08 7.25635830362148 0.05238024222538362 AS(ph)DPGLPAEEPKEK ddPTM_A459_Selumetinib_30min_R2 2 ASDPGLPAEEPKEK 14 1 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 AS(1)DPGLPAEEPKEK;AS(1)DPGLPAEEPKEK 183.41 0.00032885 9876600.0 72621.0 75404.0 79851.0 87443.0 74542.0 62418.0 59783.0 58328.0 41434.0 81732.0 True False 68585.0155448965 81187.2443379255 74713.47359519525 75533.11255241137 65177.36754606484 71015.51292581057 62563.02795776718 58497.72482327977 49721.957762688915 79372.18479476118 0.8640938349151166 1.022867702934695 0.9413054937115272 0.9516320200549249 0.8211613138103608 0.8947153604180217 0.7882235838605333 0.73700534985325 0.626440583577973 1.0 16.276345897129005 -6.747368390126885 1.1185404080238368 0.7668759900827219 0.9519091701391391 0.2942016905511401 0.09885861772099351 0.5182762667187879 1.3783716069427967 0.05042207737994916 0.046167914647880295 1.7890876173226457e-07 6.747368390126885 0.18503318005641722 AS(ph)DSEEPEEK ddPTM_A459_Selumetinib_30min_R2 3 ASDSEEPEEK 10 0 Q9C0E8-3;Q9C0E8-2;Q9C0E8;Q9C0E8-4 Q9C0E8-3 LNP Protein lunapark 1 AS(0.954)DS(0.046)EEPEEK;AS(1)DSEEPEEK;AS(0.966)DS(0.034)EEPEEK 132.17 0.0024854 3409700.0 48662.0 14110.8 29345.3 39499.0 31577.4 30363.5 120709.0 88076.0 71785.0 26909.5 True False 45957.56084942029 15193.052986626733 27457.255346746835 34119.168060424454 27610.364706462242 34545.79651259008 126322.20768034575 88332.28657823318 86144.00584048433 26132.55281572242 1.758632659177879 0.5813841875213188 1.0506916618657867 1.305619405077676 1.0565506133733213 1.3219449609915608 4.8339023198814735 3.380162940877664 3.2964252075922924 1.0 14.673560443919952 -7.136571011238077 7.8065117282123015 3.321303804435978 1.130016352369673 0.5158440810326799 0.9179278353783857 0.1947097300882642 11.501978424094794 0.3312323662332092 0.2564408537765788 7.301784120646912e-08 7.136571011238077 -2.1912874520663053 AS(ph)GEMASAQYITAALR ddPTM_A459_Selumetinib_30min_R1 2 ASGEMASAQYITAALR 16 0 A6NJA2;P54578-2;P54578-3;P54578 A6NJA2 USP14 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 14 1 AS(0.999)GEMAS(0.001)AQYITAALR;AS(1)GEMASAQYITAALR 201.9 5.3936e-07 65188000.0 2367.01 2885.58 2102.84 2098.75 2299.69 2130.67 2961.9300000000003 2842.13 1680.47 2824.76 True False 2422.156727600301 2547.7349521302526 1817.285878073303 1732.2427109167802 2091.683445543246 2109.237394293575 2738.5092354364774 2766.7474798606695 2851.6348533273185 3187.345461492447 0.7599291500916086 0.7993281503089087 0.5701565456360587 0.5434750427415773 0.656246230856894 0.6617536190463468 0.8591818077210225 0.8680412943268357 0.8946739183998164 1.0 11.638139679231763 -7.351809329383718 2.637830694340245 0.9095680568862577 0.6587103871927886 0.6947589180899626 0.07854601715452184 0.1901104525985946 2.5799665309658084 0.042324370511344675 0.02649291387180416 4.448265191573936e-08 7.351809329383718 -0.2508576696934691 AS(ph)GEMASAQYITAALR ddPTM_A459_Selumetinib_30min_R2 7 ASGEMASAQYITAALR 16 0 A6NJA2;P54578-2;P54578-3;P54578 A6NJA2 USP14 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 14 1 AS(1)GEMASAQYITAALR;AS(1)GEMASAQYITAALR;AS(1)GEMASAQYITAALR;AS(1)GEMASAQYITAALR;AS(1)GEMASAQYITAALR;AS(0.999)GEMAS(0.001)AQYITAALR;AS(0.843)GEMAS(0.155)AQY(0.002)ITAALR 237.73 2.6212e-21 116924800.0 60932.8 41221.5 61677.2 78523.2 92295.4 68879.4 90050.9 89390.4 87166.29999999999 47134.5 True False 57546.3989093247 44383.056501986655 57708.956101057905 67828.20469992448 80700.42672065516 78366.9121250612 94238.44528247307 89650.51126462263 104601.99562991451 45773.60451486164 1.2571961399858886 0.9696211817353492 1.2607474703531625 1.4818191710880495 1.7630341236171074 1.7120546427497807 2.0587945013566937 1.958563504333926 2.285203377329671 1.0 15.482228283263439 -6.033068969019236 1.3314927124969373 1.8838943451920853 1.0973672272190027 0.43112381908259656 0.32399381083659734 0.3603274361004115 1.2958633095569394 0.11278557621484435 0.20027136616124544 9.266826479691748e-07 6.033068969019236 -0.7865271179730826 AS(ph)GEWDSGTENR ddPTM_A459_Selumetinib_30min_R2 1 ASGEWDSGTENR 12 0 A0A0U1RQE4;Q5HYK7-2;Q5HYK7;Q5HYK7-3;A0A0U1RQN2;A0A494C1M0 A0A0U1RQE4;A0A494C1M0 SH3D19 SH3 domain-containing protein 19 1 AS(0.998)GEWDS(0.002)GT(0.001)ENR 181.98 0.00010415 10858000.0 30299.0 34041.0 36146.0 32296.0 38702.0 28686.0 31767.0 42609.0 32698.0 34315.0 True False 28615.102876507044 36651.83524093322 33820.40571278915 27897.2290862925 33839.90875973012 32637.236114418953 33244.22844511631 42732.98513570032 39238.513658454496 33324.236788922695 0.8586874189424493 1.099855203679163 1.014889130905209 0.837145326477989 1.0154743820263226 0.9793843538306597 0.9975990944874997 1.2823394998172977 1.1774767388370546 1.0 15.02428421380008 -7.6491948893369575 7.275402569690093 1.1714311877160977 0.9735101525341794 0.4240499574793677 0.09649204588511541 0.19333459337339268 11.556213974739487 0.044580976009270835 0.025522121022479874 2.242875209278537e-08 7.6491948893369575 -0.19792103518191828 AS(ph)GNYATVISHNPETK ddPTM_A459_Selumetinib_30min_R2 1 ASGNYATVISHNPETK 16 0 G3V1A1;E9PKZ0;P62917 G3V1A1 RPL8 60S ribosomal protein L8 1 AS(0.831)GNY(0.005)AT(0.163)VIS(0.002)HNPETK 61.087 0.046583 3907700.0 20899.0 33929.0 20651.0 18894.0 17268.0 16862.0 34064.0 26179.0 10491.0 15761.0 True False 19737.51724532562 36531.24520106999 19322.33714310875 16320.604606032033 15098.639462121331 19184.587442004195 35648.043496535494 26255.176555833244 12589.493143031556 15305.938978004104 1.2895332507002712 2.386736629067214 1.2624078255425257 1.0662922823281922 0.9864562692834018 1.2534080705256978 2.3290334260292473 1.7153587632594183 0.822523411410675 1.0 13.901803932572266 AS(ph)GQAFELILSPR ddPTM_A459_Selumetinib_30min_R1 2 ASGQAFELILSPR 13 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 AS(0.999)GQAFELILS(0.001)PR;AS(1)GQAFELILSPR 132.25 0.0014418 105497000.0 1538.96 1675.08 1764.3899999999999 2117.62 1900.29 1808.03 1628.92 1641.8600000000001 1130.71 1540.46 True False 1574.8147737051208 1478.9608548764352 1524.795529100529 1747.8174196505481 1728.4091050234497 1789.8428597598931 1506.0492529489834 1598.3125392870984 1918.7322862090564 1738.193046351074 0.9060068310657857 0.8508611042836494 0.8772302548911223 1.0055369990805556 0.9943711998226185 1.029714658862113 0.8664453330489259 0.9195253327254866 1.1038660465458552 1.0 10.763372603607886 -5.752856670766755 24.595577618074493 0.9820181353577666 0.875315515603665 0.4064554298721088 0.06079228736366966 164.10323706256597 470266.28692944045 0.017059335503833525 0.028946695758719013 1.766620758372405e-06 5.752856670766755 -0.10670261975410156 AS(ph)GQAFELILSPR ddPTM_A459_Selumetinib_30min_R2 4 ASGQAFELILSPR 13 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 AS(1)GQAFELILSPR;AS(1)GQAFELILSPR;AS(1)GQAFELILSPR;AS(1)GQAFELILSPR 161.94 0.0003635 32202100.0 12626.099999999999 17631.1 20832.4 20619.7 16832.3 18583.9 15380.0 10029.800000000001 11095.4 18857.0 True False 11924.391908282963 18983.34867707816 19492.06606460213 17811.261289033482 14717.67599132874 21143.663537152268 16095.200474891835 10058.985057477232 13314.790031378556 18312.549413630048 0.6511595758156768 1.0366305776599753 1.064410291780246 0.972625978323725 0.8036934486235084 1.1545996714916722 0.878916425634989 0.5492946301616705 0.72708554831084 1.0 14.160545031982783 -7.53491608163638 24.46102167864576 0.7257350426673939 0.9566764647475837 0.1932371879307333 0.16748907513830608 227.95549977808344 463219.4932733735 0.07583306757203959 0.04382658272345948 2.917990800478903e-08 7.53491608163638 0.23094142208018986 AS(ph)GVAVSDGVIK ddPTM_A459_Selumetinib_30min_R1 2 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 1 AS(0.869)GVAVS(0.131)DGVIK;AS(0.729)GVAVS(0.271)DGVIK 174.94 0.00012235 38959000.0 4428.9 5415.1 5610.799999999999 5798.299999999999 5447.4 5305.5 5342.0 4442.9 2709.4 3580.7 True False 4532.084752860765 4781.09757458831 4848.8841779182885 4785.735752571177 4954.683631816583 5252.131487008571 4939.048639131129 4325.059859426897 4597.653913253457 4040.3177239715947 1.1217149398849176 1.1833469299262276 1.200124472674362 1.1844949035015107 1.2263103969323916 1.2999303138580336 1.2224406535721875 1.0704751841088882 1.137943653781269 1.0 11.980253033276444 -8.278686413541845 1.260665342557255 1.0166943675976339 1.2056276648497837 0.5575525122724767 0.05403005902775785 0.33022067849344555 1.0473111804700321 0.053703024924453835 0.017105185534785513 5.26397219314928e-09 8.278686413541845 0.1889332972521498 AS(ph)GVAVSDGVIK ddPTM_A459_Selumetinib_30min_R2 3 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 1 AS(1)GVAVSDGVIK;AS(1)GVAVSDGVIK;AS(0.994)GVAVS(0.006)DGVIK 149.82 0.00056572 41522400.0 188676.0 165235.0 176013.0 205128.0 187846.0 171687.0 153695.0 148773.0 123469.0 179016.0 True False 178190.1432498711 177907.99318573496 164688.51520846455 177189.2125344625 164247.10611545292 195335.3258305879 160842.1220408648 149205.904799304 148166.25001210242 173847.34294057364 1.0249805388787676 1.0233575628852112 0.9473168379959661 1.0192230121977257 0.944777776509346 1.1236025959704172 0.9251917188969957 0.8582581837348366 0.8522779094918361 1.0 17.407461491713732 -7.506657559773532 24.63080495450882 0.8915057985405848 1.0097185260693402 0.42163493198948176 0.06000446945168696 512.1466945205623 777665.0557932503 0.024619054063552078 0.01606192182438892 3.1141708860457786e-08 7.506657559773532 0.11821272752875545 AS(ph)HSSERPPPR ddPTM_A459_Selumetinib_30min_R2 1 ASHSSERPPPR 11 1 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 AS(0.994)HS(0.005)S(0.001)ERPPPR 63.602 0.047264 8427200.0 1083.9 595.51 2742.1 2256.7 2755.8 2486.8 3368.6 4723.3 3709.6 3203.9 True False 1023.6611771954844 641.1837021335492 2565.6762713727417 1949.3335669753626 2409.591766835417 2829.3341270772157 3525.24657475427 4737.04402101559 4451.623654884174 3111.395082268088 0.32900391950522545 0.2060759515201621 0.8246063915169725 0.6265143176720498 0.77444095112438 0.9093458247079118 1.1330115531919207 1.5224823256975988 1.430748438298331 1.0 11.603345883340037 -6.4581511822893045 0.646474163693523 1.361904817275805 0.29234506353206735 0.7697838783357407 0.19379914637054016 0.3871040221560905 0.3558556348076298 0.14292085060506143 0.21381619038299657 3.482160764068491e-07 6.4581511822893045 -1.0695597537437376 down AS(ph)IY(ph)QNQNS(ph)S ddPTM_A459_Selumetinib_30min_R2 1 ASIYQNQNSS 10 0 J3KMZ8;Q92785-2;Q92785;H0YEI1 J3KMZ8 DPF2 Zinc finger protein ubi-d4 3 AS(1)IY(1)QNQNS(0.666)S(0.334) 116.25 0.013813 61978000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 AS(ph)LEDAPVDDLTR ddPTM_A459_Selumetinib_30min_R1 4 ASLEDAPVDDLTR 13 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 AS(1)LEDAPVDDLTR;AS(1)LEDAPVDDLTR;AS(1)LEDAPVDDLTR;AS(1)LEDAPVDDLTR 253.06 3.638e-23 282910000.0 8666.49 11612.539999999999 6191.640000000001 6651.599999999999 8637.16 8090.15 9494.65 8255.33 4998.4 8298.94 True False 8868.402354945996 10252.938418276615 5350.849296244028 5490.02292599597 7855.9304030144485 8008.770436268475 8778.460906313432 8036.371831308975 8481.919731308068 9364.18978752111 0.947054956827572 1.0949092928402484 0.5714161521346638 0.586278476896322 0.8389332746633782 0.8552550319880432 0.9374501270800565 0.858202579578042 0.9057825528708557 1.0 13.192938459045893 -6.910743217957717 2.75740286746907 0.9124240769227735 0.7977085058896352 0.11944098239457557 0.14811177376681323 0.7230052931524644 11.131752385382324 0.06459092440830577 0.05495504414561044 1.228165184543505e-07 6.910743217957717 -0.11471557103313834 AS(ph)LEDAPVDDLTR ddPTM_A459_Selumetinib_30min_R2 4 ASLEDAPVDDLTR 13 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 AS(1)LEDAPVDDLTR;AS(1)LEDAPVDDLTR;AS(1)LEDAPVDDLTR;AS(1)LEDAPVDDLTR 234.04 1.5563e-13 272343000.0 119025.0 107258.0 121802.0 146490.0 148609.0 136841.0 139225.0 160639.0 142793.0 117269.0 True False 112410.06699482666 115484.34371117206 113965.39192799073 126537.80929065484 129939.40883868348 155689.60563108156 145699.23836910364 161106.4328947818 171355.589969775 113883.13926854635 0.9870650538509826 1.0140600658965848 1.0007222549358288 1.111119785627508 1.1409889969073916 1.367099700895599 1.2793749742491043 1.4146644879087749 1.5046616300741729 1.0 16.79719464207765 -6.430735679626227 1.4384715544285929 1.34262461137599 1.0034093399449633 0.5225585977927752 0.1275739806502208 0.29155931307371824 1.225605924504968 0.0488520162427811 0.05857281794145674 3.7090639420739504e-07 6.430735679626227 -0.3392152714310268 AS(ph)LEDAPVDDLTRK ddPTM_A459_Selumetinib_30min_R1 1 ASLEDAPVDDLTRK 14 1 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 AS(1)LEDAPVDDLTRK 80.508 0.017366999999999997 3515200.0 1269.5 1654.0 1757.6 1752.5 1813.4 1554.2 1468.5 1681.7 811.59 1232.8 True False 1299.0768799830082 1460.3489110762619 1518.9275738057286 1446.4587734992995 1649.3782901817742 1538.5661591006933 1357.729862703867 1637.0958530685405 1377.2089538116834 1391.041888488894 0.9338876785329674 1.0498238213823 1.0919351792171825 1.0398384013227706 1.1857143223584117 1.1060530756353115 0.9760524639403818 1.176884655031444 0.9900557022820947 1.0 10.441950149118291 -4.765158704678212 3.034007811846547 1.0779281621355128 0.90746953587971 0.2529676115156202 0.06931373393061234 0.5146557871221861 6.697614716663887 0.016832837255336387 0.2194231470105663 1.7172807248233134e-05 4.765158704678212 -0.17045862625580277 AS(ph)LEDAPVDDLTRK ddPTM_A459_Selumetinib_30min_R2 2 ASLEDAPVDDLTRK 14 1 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 AS(1)LEDAPVDDLTRK;AS(1)LEDAPVDDLTRK 76.34100000000002 0.02178 4939200.0 27591.0 28585.0 30810.0 37101.0 38150.0 23391.0 23962.0 27549.0 17188.8 35200.0 True False 26057.60267552414 30777.377584738286 28827.718143391638 32047.77979720516 33357.25593467275 26612.897927643204 25076.28047980221 27629.16302901754 20627.04029519979 34183.68453941654 0.7622818612627209 0.9003528437447839 0.8433180487068606 0.9375168367310284 0.9758238874516042 0.778526314123815 0.733574534684441 0.8082558507453721 0.603417699792284 1.0 15.061020287981155 -6.88877885399098 9.416358079406857 0.7683533665238047 0.8853793023383542 0.17252547372492189 0.10569696548135285 0.43006114263158807 34.07600529975512 0.03561147356744555 0.031413175138692254 1.2918769395866528e-07 6.88877885399098 0.11702593581454945 AS(ph)LENSLR ddPTM_A459_Selumetinib_30min_R1 2 ASLENSLR 8 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 AS(1)LENSLR;AS(0.999)LENS(0.001)LR 106.16 0.013847 14857400.0 2620.4 2594.0 3040.7 3793.7 4249.700000000001 2876.2 4513.0 8246.8 1244.43 3317.8999999999996 True False 2681.4502215891885 2290.293274082117 2627.7896413695253 3131.2015115687836 3865.315385345474 2847.268039380654 4172.580776562854 8028.068074618321 2111.7068204288785 3743.7847840828194 0.7162404828903941 0.6117587965578556 0.7019072390437371 0.8363732672031491 1.032461962498314 0.7605319759528323 1.1145354279720128 2.144372216253103 0.5640566811978804 1.0 11.870281786928293 -7.403772141743733 4.683605020068536 1.3265784874310893 0.7825885818196845 0.22092528429045488 0.38384989668711045 0.2826477005212982 9.587656027861316 0.1600096973246805 0.1047762779625242 3.946643135371824e-08 7.403772141743733 -0.5439899056114048 AS(ph)LENVHPPIAPPPTEIPER ddPTM_A459_Selumetinib_30min_R2 1 ASLENVHPPIAPPPTEIPER 20 0 C9J2P9;Q75N03-2;Q75N03 C9J2P9 CBLL1 E3 ubiquitin-protein ligase Hakai 1 AS(1)LENVHPPIAPPPTEIPER 85.11 0.0070342 0.0 7408.2 7342.2 11387.0 8710.5 11427.0 11128.0 6694.6 6091.8 8628.9 9987.0 True False 6996.481901374283 7905.32313110601 10654.372817228188 7524.114873549381 9991.438101323854 12660.780990073692 7005.912165098235 6109.526129448218 10354.921111610429 9698.649360657755 0.7213872407590356 0.8150952609106261 1.0985419124901343 0.7757899676289669 1.0301886097515585 1.3054169213944082 0.722359568283547 0.6299357675751538 1.0676663034767313 1.0 13.243568135430552 -5.016952642824983 15.153552308325851 0.9422359881373294 0.7447909650421418 0.13933517828132802 0.18901484710834177 8.438642882963181 7559.928419683306 0.049974932158712154 0.14397395401298468 9.617171420783289e-06 5.016952642824983 -0.19744502309518763 AS(ph)LGSLEGEAEAEASSPK ddPTM_A459_Selumetinib_30min_R2 1 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 AS(0.662)LGS(0.338)LEGEAEAEASSPK 122.19 0.00060523 14185000.0 18215.0 18419.0 18984.0 21893.0 19760.0 15682.0 18322.0 19030.0 16810.0 20977.0 True False 17202.683220422314 19831.67807358035 17762.59010821637 18911.13563246847 17277.572143358662 17842.053152977685 19174.009304354237 19085.3741494139 20172.469710643454 20371.33950520855 0.8444551825383857 0.9735087900581982 0.8719402130466102 0.9283206746239375 0.8481313729488003 0.8758409405731922 0.9412247682314567 0.9368737948986685 0.9902377654393199 1.0 14.314253226519186 -7.954008870358883 1.3763077865256939 0.9989685148478135 0.8944328614883771 0.5330601328129198 0.037503408597786024 0.34798915185858875 1.184781983983757 0.03235921471761479 0.011181372863924998 1.1117090206640657e-08 7.954008870358883 -0.10453565335943638 AS(ph)LLTDEEDVDMALDQR ddPTM_A459_Selumetinib_30min_R2 1 ASLLTDEEDVDMALDQR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 AS(0.738)LLT(0.262)DEEDVDMALDQR 180.56 9.2218e-10 0.0 1303.5 2139.8 2134.9 1783.9 2591.6 688.89 782.65 1869.3 1089.8 2312.7 True False 1231.056688323936 2303.915779458561 1997.5428583033674 1540.9297426008545 2266.0200388020394 783.7783443792117 819.0447757915537 1874.7393535207257 1307.7904515561709 2245.9263418837672 0.548128701002451 1.02581983054981 0.8894071105768907 0.6860998572679824 1.0089467301502946 0.3489777602064273 0.36468015914741936 0.834728779194197 0.5822944533698571 1.0 11.133094898090022 -4.493315504451209 15.949281731695848 0.7332264724133446 1.3587084231910525e-05 0.05585604326612159 0.23999387754915683 6855115.332386016 112133305.08936153 0.06204103956254497 133808154.64000097 3.211326739708264e-05 4.493315504451209 -0.7332128853291127 AS(ph)LSDLSSLDDVEGMSVR ddPTM_A459_Selumetinib_30min_R1 1 ASLSDLSSLDDVEGMSVR 18 0 H7BYJ1;A0A087WTM5;Q969K3;Q969K3-2 H7BYJ1 RNF34 E3 ubiquitin-protein ligase RNF34 1 AS(0.979)LS(0.021)DLSSLDDVEGMSVR 204.9 1.3137e-29 0.0 333.92 338.74 302.46 275.24 215.9 206.71 405.23 348.25 165.41 179.08 True False 341.69968630478627 299.0801633240462 261.38759329385556 227.17450089469187 196.3718831202409 204.63068507766314 374.6631748474552 339.0132787245759 280.68868893159174 202.06666238691696 1.691024547386744 1.4801064153342027 1.2935710928572224 1.124255224544158 0.9718173240483792 1.0126889941193595 1.8541562988260314 1.6777298873548658 1.3890895490426294 1.0 7.658687510619688 -7.251853141385695 24.98802558126321 1.5367214341613107 1.2540973257535388 0.10852119842491925 0.28790208151065066 1252.63790929666 3265201.074198078 0.11662755828654942 0.08914800929430676 5.5994691802968954e-08 7.251853141385695 -0.28262410840777186 AS(ph)LSDLSSLDDVEGMSVR ddPTM_A459_Selumetinib_30min_R2 1 ASLSDLSSLDDVEGMSVR 18 0 H7BYJ1;A0A087WTM5;Q969K3;Q969K3-2 H7BYJ1 RNF34 E3 ubiquitin-protein ligase RNF34 1 AS(0.928)LS(0.072)DLSSLDDVEGMSVR 79.311 0.036552 0.0 876.02 1004.0 494.97 821.52 891.85 867.15 2213.3 1012.1 838.96 1240.9 True False 827.3343153859104 1081.0035716311784 463.1241690825882 709.6275587989542 779.8078297598397 986.5920412960467 2316.2228355707475 1015.0450434378254 1006.7754425009772 1205.0719927546027 0.6865434765393194 0.8970448057299684 0.38431244927032127 0.5888673565276864 0.6471047658964534 0.8186996687565979 1.9220617934006008 0.8423107080246667 0.8354483786480249 1.0 10.23490362239326 -7.0127047134076115 24.564434007501237 1.1701810501368395 0.6473822847738162 0.3775382884637265 0.3082735716927902 520.2335266321548 1005865.6854116597 0.11608930642494526 0.09460194235657932 9.711700631959345e-08 7.0127047134076115 -0.5227987653630233 AS(ph)LSDLTDLEDIEGLTVR ddPTM_A459_Selumetinib_30min_R1 2 ASLSDLTDLEDIEGLTVR 18 0 J3KSI3;J3KSU7;K7EN88;Q8WZ73-3;Q8WZ73-2;Q8WZ73 J3KSI3 RFFL;hCG_2039718 E3 ubiquitin-protein ligase rififylin 1 AS(0.498)LS(0.498)DLT(0.003)DLEDIEGLTVR;AS(1)LSDLTDLEDIEGLTVR 253.36 2.442799999999999e-94 1580100.0 220.651 425.87 474.54 372.68 455.26 452.51 481.65 416.81 158.3 374.95 True False 225.79173898789347 376.0089424184084 410.10007446163524 307.5984340700252 414.08181338268116 447.95816024620643 445.3187527213601 405.75484481031003 268.6235382254457 423.0784848222836 0.5336875948270886 0.8887451286405004 0.9693238705671833 0.7270481603412983 0.9787352187304407 1.0588062884700309 1.0525677118949186 0.9590533656674826 0.6349260193136091 1.0 8.724781510710232 -4.7630673786978255 4.3978815479405124 0.9259543129656463 0.49932645103432294 0.44265267763572547 0.1300791888578522 0.2035887087057324 8.396439496381037 0.0334316871309455 0.27736825175170465 1.7255701573202382e-05 4.7630673786978255 -0.4266278619313234 AS(ph)LSDLTDLEDIEGLTVR ddPTM_A459_Selumetinib_30min_R2 1 ASLSDLTDLEDIEGLTVR 18 0 J3KSI3;J3KSU7;K7EN88;Q8WZ73-3;Q8WZ73-2;Q8WZ73 J3KSI3 RFFL;hCG_2039718 E3 ubiquitin-protein ligase rififylin 1 AS(0.994)LS(0.006)DLTDLEDIEGLTVR 198.61 2.0901e-10 31156000.0 32450.0 15382.0 25118.0 29588.0 24212.0 14832.0 37342.0 27804.0 28347.0 14568.0 True False 30646.55890764227 16561.749939074485 23501.935226410613 25558.063357853072 21170.272101973693 16874.973368509432 39078.47699176925 27884.9050368 34017.19208135694 14147.383987790341 2.166235039219354 1.1706581197886352 1.6612212721937538 1.806557550138635 1.4964089559062181 1.1927981443829538 2.7622404979956197 1.9710290652226299 2.404486377885473 1.0 13.78824768654597 -7.242755895030576 24.998013248416193 2.1153581892987243 1.5734765317118764 0.1568772998438691 0.4993409363379225 1223.419311631891 1636905.2039507243 0.17883011902927423 0.13827705472704704 5.717999393663853e-08 7.242755895030576 -0.5418816575868479 AS(ph)LSSAPVVLVGDHA ddPTM_A459_Selumetinib_30min_R2 1 ASLSSAPVVLVGDHA 15 0 Q9HBH9 Q9HBH9 MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 1 AS(0.943)LS(0.034)S(0.022)APVVLVGDHA 143.94 0.00034272 0.0 11507.0 9546.4 10115.0 10125.0 10134.0 9177.3 8020.4 7828.0 7866.7 9305.2 True False 10867.487006170719 10278.578183485937 9464.211912379302 8745.957533400779 8860.876320890522 10441.389771765209 8393.3644921211 7850.7781840048365 9440.259813963052 9036.534698186895 1.202616641128063 1.1374468783424523 1.0473275684182584 0.9678441820353527 0.9805613121441765 1.155463916257654 0.928825570027984 0.8687819442092143 1.044676983961248 1.0 13.141553923210683 -5.208161215718419 1.7685657016089467 0.990007754281456 1.2078466046830567 0.5038025902860271 0.07076482124412826 0.39491330958630877 2.0662863450789137 0.02143438535869963 0.10794190995540198 6.1921117322664395e-06 5.208161215718419 0.21783885040160067 AS(ph)LVSEEEEDEEEDK ddPTM_A459_Selumetinib_30min_R1 3 ASLVSEEEEDEEEDK 15 0 Q96GN5-5;Q96GN5-2;Q96GN5;C9J8L0;C9IZR6;Q96GN5-4;C9JFL7 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 AS(0.85)LVS(0.15)EEEEDEEEDK;AS(0.875)LVS(0.125)EEEEDEEEDK;AS(0.5)LVS(0.5)EEEEDEEEDK 82.59 0.016600999999999998 1326950000.0 23522.9 24255.6 9700.8 11986.1 52316.0 12926.5 40691.0 26484.0 787.71 5140.7 True False 24070.93780240433 21415.74307587747 8383.484642680141 9892.95264196288 47584.02703713998 12796.471146322934 37621.645109487945 25781.558287843975 1336.686337937877 5800.558919658389 4.149761796372191 3.692013713247258 1.4452891107213972 1.7055171370529763 8.203352072827895 2.2060755391958944 6.485865522714764 4.444667944061212 0.2304409551651616 1.0 12.50197620417294 -4.840245241328636 5.268569535029968 3.4848690058434175 4.143796046319869 0.005206023257287251 2.4069678568416735 1.649092550580722 73.44878132970145 0.5959974544924564 2.777972722077249 1.4446237771804612e-05 4.840245241328636 0.6589270404764513 AS(ph)LVSEEEEDEEEDK ddPTM_A459_Selumetinib_30min_R2 1 ASLVSEEEEDEEEDK 15 0 Q96GN5-5;Q96GN5-2;Q96GN5;C9J8L0;C9IZR6;Q96GN5-4;C9JFL7 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 AS(0.874)LVS(0.126)EEEEDEEEDK 65.949 0.042712 424290000.0 26813.0 33677.0 58785.0 83883.0 104550.0 69771.0 44283.0 65811.0 81902.0 71325.0 True False 25322.840800943388 36259.91761137767 55002.83710026865 72457.99069375372 91415.49431114102 79381.32193192223 46342.24724509984 66002.49911440244 98284.68853308288 69265.6619253945 0.3655901076671789 0.523490523348105 0.7940852014019844 1.0460881868392111 1.3197808520129923 1.146041483259385 0.6690508104147581 0.9528891701849788 1.4189525632332014 1.0 16.079852700925578 -5.387871620963226 1.909137306661797 1.073790324331784 0.3888588357928617 0.6347517878629465 0.1936345255942847 0.2583451379240329 1.7523570855230655 0.06019656470405159 0.19836915000797598 4.0938165656009e-06 5.387871620963226 -0.6849314885389222 AS(ph)LYNAVTIEDVQK ddPTM_A459_Selumetinib_30min_R2 1 ASLYNAVTIEDVQK 14 0 Q9Y617-2;Q9Y617 Q9Y617-2 PSAT1 Phosphoserine aminotransferase 1 AS(0.993)LY(0.001)NAVT(0.006)IEDVQK 78.22800000000002 0.038533 3164500.0 10472.0 11689.0 11396.0 14857.0 16366.0 16069.0 8549.6 13425.0 11598.0 13844.0 True False 9890.008162737444 12585.50871394108 10662.793767026644 12833.450970245478 14309.956766103649 18282.358890141462 8947.173340711004 13464.06452737161 13917.924075195879 13444.287748968258 0.7356290156387365 0.936123128940536 0.7931096065572479 0.9545653298911535 1.064389355040532 1.3598607253511432 0.6654999883796469 1.001471017191288 1.0352295588335625 1.0 13.71470570573458 -5.93064275605267 4.414826152606858 1.0197952672546815 0.834258675941504 0.2283324630904323 0.16316335996433734 0.35188180131221586 13.42229268631313 0.04809575138012517 0.07255433019170422 1.1731599920786514e-06 5.93064275605267 -0.18553659131317746 AS(ph)PAAAEEVVPEWASCLK ddPTM_A459_Selumetinib_30min_R2 2 ASPAAAEEVVPEWASCLK 18 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 AS(1)PAAAEEVVPEWASCLK;AS(1)PAAAEEVVPEWASCLK 145.61 0.00010904 1343300.0 12360.900000000001 9811.7 11815.0 12878.5 14958.2 13295.0 12318.7 11266.6 8929.1 11429.900000000001 True False 11673.930662603258 10564.225840411986 11054.835763199351 11124.426083348342 13079.01718799532 15126.265570006262 12891.543959040971 11299.38394071396 10715.169499899255 11099.88908855333 1.0517159738687754 0.9517415675176663 0.995941101303396 1.002210562159609 1.1783016103722108 1.3627402444592984 1.161411961524487 1.0179726887871663 0.9653402312775528 1.0 13.438257640611901 -6.243129527746082 20.34445375196876 1.1299712150345218 0.9966076320026828 0.19901821853307777 0.10914534147222356 118.54793619062227 131718.1309643364 0.03568531126909032 0.045878799711657085 5.713082193504601e-07 6.243129527746082 -0.13336358303183904 AS(ph)PAPGSGHPEGPGAHLDMNSLDR ddPTM_A459_Selumetinib_30min_R1 10 ASPAPGSGHPEGPGAHLDMNSLDR 24 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 1 AS(0.999)PAPGS(0.001)GHPEGPGAHLDMNSLDR;AS(0.997)PAPGS(0.003)GHPEGPGAHLDMNSLDR;AS(0.696)PAPGS(0.304)GHPEGPGAHLDMNSLDR;AS(0.999)PAPGS(0.001)GHPEGPGAHLDMNSLDR;AS(0.955)PAPGS(0.045)GHPEGPGAHLDMNSLDR;AS(0.845)PAPGS(0.155)GHPEGPGAHLDMNSLDR;AS(0.981)PAPGS(0.019)GHPEGPGAHLDMNSLDR;AS(0.961)PAPGS(0.039)GHPEGPGAHLDMNSLDR;AS(0.84)PAPGS(0.16)GHPEGPGAHLDMNSLDR;AS(0.836)PAPGS(0.164)GHPEGPGAHLDMNSLDR 125.04 7.659900000000001e-08 412018000.0 9250.300000000001 12043.689999999999 11055.210000000001 11446.19 11699.26 13416.96 11744.23 11806.66 4490.74 8266.16 True False 9465.813992049483 10633.609175840422 9553.973203921732 9447.32778809697 10641.063998672118 13281.99756402498 10858.353275766185 11493.509023363395 7620.457789327465 9327.202155216872 1.0148610306205363 1.1400641906204267 1.0243128694898098 1.0128790639337555 1.1408634466789571 1.4240066145233188 1.164159744269391 1.2322568796190259 0.8170143267523376 1.0 13.187228670977015 -4.754637829107126 23.500108495854917 1.1207859407218523 1.014860631662712 0.023218314334009782 0.1532455489396795 452.6325514908824 1563579.7734384933 0.039042376625403455 0.3589585329211008 1.7593902093993217e-05 4.754637829107126 -0.10592530905914033 AS(ph)PAPGSGHPEGPGAHLDMNSLDR ddPTM_A459_Selumetinib_30min_R2 6 ASPAPGSGHPEGPGAHLDMNSLDR 24 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 1 AS(0.997)PAPGS(0.003)GHPEGPGAHLDMNSLDR;AS(0.998)PAPGS(0.002)GHPEGPGAHLDMNSLDR;AS(0.992)PAPGS(0.008)GHPEGPGAHLDMNSLDR;AS(0.98)PAPGS(0.02)GHPEGPGAHLDMNSLDR;AS(0.917)PAPGS(0.083)GHPEGPGAHLDMNSLDR;AS(0.983)PAPGS(0.017)GHPEGPGAHLDMNSLDR 115.85 7.8719e-08 322250600.0 162722.0 40643.6 131854.6 163386.0 93093.7 101765.6 191682.0 133188.0 153254.0 139966.3 True False 153678.56266777715 43760.83343022804 123371.21858843388 141132.54494342898 81398.43713776262 115782.88766386082 200595.5928106771 133575.5550295396 183909.08227453657 135925.1092428788 1.130612022486408 0.3219481203582016 0.9076411214648141 1.0383110650383605 0.5988476859879893 0.8518138282822587 1.4757802581732076 0.9827143474342118 1.3530177264446208 1.0 17.0524524620659 -7.102404215240704 7.416166929696408 1.199910670700849 0.7857797917832716 0.3714483903765453 0.2518933585836547 0.2829560894284085 18.079972336247856 0.0922593004841799 0.0714632350517814 7.899430541504982e-08 7.102404215240704 -0.41413087891757727 AS(ph)PATPAGHPVSGLLLR ddPTM_A459_Selumetinib_30min_R2 3 ASPATPAGHPVSGLLLR 17 0 Q9HCM7;A0A3B3IRR3 Q9HCM7 FBRSL1 Fibrosin-1-like protein 1 AS(0.982)PAT(0.018)PAGHPVSGLLLR;AS(0.996)PAT(0.004)PAGHPVSGLLLR;AS(0.941)PAT(0.059)PAGHPVSGLLLR 102.59 0.0023297 13448000.0 72213.0 83496.0 88274.0 84912.0 97707.0 78253.0 71499.0 63780.0 62603.0 85776.0 True False 68199.69055154313 89899.87471804483 82594.54694546408 73346.83911862999 85432.17314833732 89031.64043999258 74823.84517258074 63965.5892406526 75125.34927396855 83299.42400718742 0.8187294373807263 1.07923765127461 0.9915380319837204 0.8805203636498292 1.025603408025557 1.0688145986737023 0.8982516513694575 0.7678995383585532 0.9018711734127527 1.0 16.34601889933178 -7.505270610910951 24.36756966290605 0.8675463375724831 0.9807206847994084 0.15905681889601164 0.09194048315513915 744.4472491825252 1030232.0324715386 0.03812333996907046 0.02506060550848213 3.124132099274247e-08 7.505270610910951 0.11317434722692532 AS(ph)PDMDGYPALK ddPTM_A459_Selumetinib_30min_R2 2 ASPDMDGYPALK 12 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 AS(1)PDMDGYPALK;AS(1)PDMDGYPALK 94.122 0.019362 5271600.0 88925.0 82829.0 92024.0 106011.0 123615.0 89839.0 119728.0 120400.0 109000.0 109716.0 True False 83982.90449497967 89181.71796278757 86103.27602815536 91572.11892082467 108085.37856787855 102213.5067727562 125295.58923653126 120750.34406670686 130803.04571446372 106548.21400359707 0.7882150374866387 0.8370080981345853 0.8081156200820834 0.8594430209570025 1.0144269388150382 0.9593169414299659 1.1759520364395906 1.1332929903698838 1.227641842124616 1.0 16.701146884828674 -6.609936475802025 1.0290518513625997 1.146530524405427 0.8046735906012396 0.7984881324991455 0.06756524843853291 0.2065969103780285 0.47079187309649445 0.03379482645446684 0.03586125900524915 2.455067991902588e-07 6.609936475802025 -0.34185693380418736 AS(ph)PDSPLTR ddPTM_A459_Selumetinib_30min_R2 1 ASPDSPLTR 9 0 F5GX43;A0A087WXP8;A0A1B0GX50;J3QQJ3;J3QRK4;E7ES00;Q9Y2T1 F5GX43 AXIN2 Axin-2 1 AS(0.981)PDS(0.012)PLT(0.007)R 139.43 0.0023803 4102700.0 16900.0 14526.0 23930.0 24091.0 19729.0 15970.0 15991.0 19827.0 16684.0 17841.0 True False 15960.765656060232 15640.097491548313 22390.369853014006 20809.76424070699 17250.466640502193 18169.722538773975 16734.61318556537 19884.693287463448 20021.266189909296 17325.88397351507 0.9212093120592517 0.9027012714304387 1.2923075028807005 1.201079510431762 0.9956471292819367 1.0487039256726425 0.965873557224928 1.1476870858571984 1.1555696794757762 1.0 14.080641340666492 -5.180896529916237 24.99999274615119 1.0992733441171858 0.9119536027096729 0.3771490168559285 0.09708634626660999 114.40092064446493 35507.778695883535 0.026238999836973323 0.06942186404344923 6.5933096125941485e-06 5.180896529916237 -0.18731974140751295 AS(ph)PEPEGEAAGK ddPTM_A459_Selumetinib_30min_R2 2 ASPEPEGEAAGK 12 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 AS(1)PEPEGEAAGK;AS(1)PEPEGEAAGK 130.1 0.0022155 8504400.0 84084.0 84774.0 83769.0 94907.0 89900.0 67848.0 70479.0 69590.0 62748.0 78799.0 True False 79410.94789492116 91275.89320862702 78379.39374079122 81980.5028762932 78605.95828380289 77193.44613717835 73756.41315148902 69792.49537875541 75299.35332560712 76523.8681256105 1.0377278336815339 1.1927767825170799 1.0242476714864301 1.0713063111462933 1.0272083757550614 1.0087499237554063 0.9638354013994845 0.9120356444108936 0.9839982631563606 1.0 16.223622180371365 -6.450388961648598 0.9130984160833546 0.9567965754667094 1.1033359317005578 0.5478773192172257 0.047285588604511875 0.39549430268833496 0.7179368645157116 0.02427720203660871 0.0314985825364559 3.544957544869211e-07 6.450388961648598 0.1465393562338484 AS(ph)PEPPDSAEGALK ddPTM_A459_Selumetinib_30min_R1 2 ASPEPPDSAEGALK 14 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 AS(1)PEPPDSAEGALK;AS(1)PEPPDSAEGALK 115.09 0.0028476 19589800.0 7308.9 6677.8 7552.5 7874.4 6386.6 6683.3 6952.0 6105.5 3981.5 6076.9 True False 7479.1831493562895 5895.9600715750075 6526.91198291293 6499.283860794797 5808.933157645814 6616.07206995088 6427.605042912691 5943.562306540986 6756.314702745501 6856.929309018629 1.0907481778351187 0.8598542883941214 0.9518709744212119 0.9478417477990568 0.8471624681919311 0.9648738920567608 0.9373882613108951 0.8667964971906112 0.9853265796191315 1.0 12.743346933589802 -4.747006131959046 24.98486148400267 0.924977439943147 1.0907486080898325 0.47418417929248924 0.05093468801486426 629.9754677475987 1090465.2048922053 0.011802143232396037 0.25402607841911695 1.7905805720095998e-05 4.747006131959046 0.16577116814668558 AS(ph)PEPPDSAEGALK ddPTM_A459_Selumetinib_30min_R2 4 ASPEPPDSAEGALK 14 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 AS(1)PEPPDSAEGALK;AS(0.999)PEPPDS(0.001)AEGALK;AS(1)PEPPDSAEGALK;AS(1)PEPPDSAEGALK 136.14 0.0005976 19896900.0 109957.4 107757.6 108347.2 114927.4 119485.1 96494.0 78935.0 92884.8 81614.5 100512.6 True False 103846.4079023479 116022.26142470477 101376.25911151181 99274.08985917683 104474.3135276532 109785.17261468116 82605.63390673517 93155.07939009361 97939.68049966148 97610.54007490243 1.0638851892701373 1.188624315936311 1.038579020602895 1.01704272697393 1.070317953855022 1.1247266179496231 0.8462778081480433 0.9543547174168909 1.0033719762692275 1.0 16.57474931927181 -7.245222944054485 24.99641244390611 0.9471973448069186 1.082913252367823 0.5407381700671812 0.05994000958701813 637.4771812737039 982624.5346008132 0.023640014663013114 0.018253050964686886 5.685609864658321e-08 7.245222944054485 0.13571590756090446 AS(ph)PEPPGPESSSR ddPTM_A459_Selumetinib_30min_R1 4 ASPEPPGPESSSR 13 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 AS(1)PEPPGPESSSR;AS(0.999)PEPPGPES(0.001)SSR;AS(1)PEPPGPESSSR;AS(1)PEPPGPESSSR 185.66 0.00012725 1107388100.0 7988.400000000001 9047.3 7323.0 7118.1 8486.8 7028.6 8082.6 7885.200000000001 4510.7 7391.1 True False 8174.514177279451 7988.037910024342 6328.576822359662 5875.057458285518 7719.170438466234 6957.898665458194 7472.922974661409 7676.0588812606575 7654.328451506743 8339.819680410663 0.9801787677113096 0.9578190196111052 0.7588385678439555 0.7044585714587325 0.9255800166276656 0.8342984539343875 0.8960533034322672 0.9204106533970863 0.9178050299439848 1.0 13.025800475407605 -8.305385014964171 0.8643878913354113 0.9947092045418088 0.8557240645579793 0.21270604827441153 0.08062276330899823 0.9607003901443 1.5540518210292917 0.08347399100961547 0.030697943942645904 4.950111541255944e-09 8.305385014964171 -0.13898513998382944 AS(ph)PEPPGPESSSR ddPTM_A459_Selumetinib_30min_R2 5 ASPEPPGPESSSR 13 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 AS(1)PEPPGPESSSR;AS(1)PEPPGPESSSR;AS(1)PEPPGPESSSR;AS(1)PEPPGPESSSR;AS(0.999)PEPPGPESSSR 121.56 0.0028177 1264652700.0 105611.2 88734.8 112792.7 117292.6 134694.9 87552.1 105415.5 108919.2 100631.9 106822.2 True False 99741.75229913075 95540.47383264787 105535.74048140644 101317.14553897911 117773.32247431576 99611.60705616746 110317.52962685062 109236.1368394558 120761.0918902143 103737.96552859248 0.9614778137483303 0.9209788657973517 1.0173299615396685 0.9766640884339867 1.1352962425492605 0.9602232562456827 1.0634248422429748 1.0530005700694784 1.1640973608348804 1.0 16.66258445591562 -5.708833887054789 1.2415207478469554 1.0607150026620449 0.9384032340645408 0.3559190618362893 0.059973855493134554 0.5562060679046703 1.6632910622725663 0.02029461543099412 0.05677094248817984 1.955087112469735e-06 5.708833887054789 -0.12231176859750403 AS(ph)PEPQR ddPTM_A459_Selumetinib_30min_R2 1 ASPEPQR 7 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 AS(1)PEPQR 93.598 0.025499 23940000.0 27725.0 10400.0 31965.0 32278.0 28886.0 45614.0 100110.0 419840.0 89168.0 94186.0 True False 26184.15549196864 11197.646558729333 29908.40670086052 27881.680717344258 25257.082435883534 51896.914457334795 104765.3133642016 421061.66489174677 107004.0915620853 91466.6054553833 0.286270113136986 0.12242333147687938 0.32698717255282433 0.30482907481402843 0.27613446798573654 0.567386470711977 1.1453941342045904 4.603446938862702 1.1698705886082224 1.0 16.480957489746302 -7.532228010259113 24.95586128547166 2.506879806271183 0.349801776621096 0.46327762891897983 0.9254687672349795 149.22254729644106 398311.58500698034 0.4037022782541895 0.23346548864016406 2.93610775242932e-08 7.532228010259113 -2.1570780296500867 AS(ph)PEPQRENAS(ph)PAPGTTAEEAMSR ddPTM_A459_Selumetinib_30min_R2 2 ASPEPQRENASPAPGTTAEEAMSR 24 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 2 AS(1)PEPQRENAS(0.981)PAPGT(0.008)T(0.012)AEEAMSR;AS(1)PEPQRENAS(0.983)PAPGT(0.009)T(0.008)AEEAMSR 82.94200000000002 0.00032343 55537000.0 78250.0 73999.0 88826.0 97285.0 102172.0 79322.0 77811.0 84896.0 66685.0 89110.0 True False 73901.17825956891 79674.48535571265 83111.03186643623 84034.61517401418 89336.23993073078 90247.88548657674 81429.36567957142 85143.03330471052 80023.8633345781 86537.16276441501 0.8539819876086561 0.920696759756441 0.9604085598772641 0.9710812382743162 1.032345377140869 1.042880106114221 0.9409756811793236 0.983889817794237 0.9247340769933903 1.0 16.401032200415457 -4.885807973653623 1.3326659970587775 0.986671425869353 0.814221661779217 0.5940725872905029 0.03412677418069706 0.81080777433632 1.471927163088734 0.010844213968298521 0.18126876751052462 1.300744584228963e-05 4.885807973653623 -0.17244976409013602 AS(ph)PFEEDQNR ddPTM_A459_Selumetinib_30min_R1 2 ASPFEEDQNR 10 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 AS(1)PFEEDQNR;AS(1)PFEEDQNR 118.61 0.0056592 23086800.0 3009.89 3007.47 2582.8 3014.52 2819.9 2872.9700000000003 2964.6499999999996 2870.76 1683.13 2740.41 True False 3080.014580773576 2655.3540142651295 2232.0699463048672 2488.0906715487067 2564.84054289378 2844.070530248049 2741.024063646592 2794.6181192573235 2856.1486790486056 3092.1683173538713 0.9960695100224377 0.8587352762664141 0.7218461989206866 0.8046427025285269 0.829463431372535 0.9197657560510379 0.8864407698194865 0.9037729620258262 0.923671801117463 1.0 11.59440313691403 -6.762807436342267 24.777319972296013 0.9181979877418597 0.8343052998917315 0.2629108977542819 0.06946613524430377 49.831166976333186 902494.1937634888 0.025054955792653776 0.02330896707117515 1.7266032881886064e-07 6.762807436342267 -0.08389268785012816 AS(ph)PFEEDQNR ddPTM_A459_Selumetinib_30min_R2 2 ASPFEEDQNR 10 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 AS(1)PFEEDQNR;AS(1)PFEEDQNR 129.74 0.0028969 54308000.0 37276.0 29039.0 36409.0 39923.0 40698.0 28723.0 35543.0 32649.0 23251.8 31792.0 True False 35204.34914765098 31266.19792489819 34066.4845791219 34485.41852898366 35585.15339526373 32679.33252856636 37195.819927118355 32744.00318466709 27902.809709574027 30874.08235446394 1.1402557246389202 1.012700476922112 1.10340071610894 1.1169698303275264 1.1525898320381542 1.05847137911263 1.2047587196301037 1.0605660375176393 0.9037615884165604 1.0 14.914108636818803 -8.075862331847288 5.4762637453350695 0.956585848459974 1.1097800476041522 0.5834823172714063 0.05360673409828572 0.155708124377665 8.160842784113834 0.03628347833330595 0.01341893528876132 8.397261313342653e-09 8.075862331847288 0.1531941991441782 AS(ph)PGGVSTSSSDGK ddPTM_A459_Selumetinib_30min_R1 3 ASPGGVSTSSSDGK 14 0 P54259 P54259 ATN1 Atrophin-1 1 AS(1)PGGVSTSSSDGK;AS(1)PGGVSTSSSDGK;AS(1)PGGVSTSSSDGK 187.16 7.0373e-15 10139000.0 6935.400000000001 8330.7 5102.2 5847.6 5960.7 5999.799999999999 6754.400000000001 6313.799999999999 3389.6099999999997 6316.7 True False 7096.98132606078 7355.337771162644 4409.349264378462 4826.426433046791 5421.555737447058 5939.447459382535 6244.91017000136 6146.337513887223 5751.920602680691 7127.509974868427 0.9957167862387719 1.0319645706701972 0.618638105022064 0.6771546374631187 0.7606521431135759 0.8333131037802829 0.8761699656711656 0.8623400788717499 0.8070028134596713 1.0 12.799182437861884 -10.331526046487067 12.56901904949389 1.0000000000000002 0.8249732124438137 0.1525098148311529 0.12040364499106744 0.0 0.0 0.1273277491974452 0.030881515236071824 4.660944734958171e-11 10.331526046487067 -0.1750267875561865 AS(ph)PGGVSTSSSDGK ddPTM_A459_Selumetinib_30min_R2 3 ASPGGVSTSSSDGK 14 0 P54259 P54259 ATN1 Atrophin-1 1 AS(0.999)PGGVSTSSSDGK;AS(1)PGGVSTSSSDGK;AS(0.997)PGGVS(0.001)T(0.001)SSSDGK 171.11 0.00014707 38951000.0 53501.0 47082.0 52404.0 55849.0 59007.0 42085.6 53518.0 48021.0 45735.0 48141.0 True False 50527.62860147211 50693.03800750912 49032.383693161144 48242.26985510125 51594.013130727 47882.50938496093 56006.69304390519 48160.733159695505 54883.27794266978 46751.04424466059 1.0807807487047274 1.084318838788264 1.0487976147989702 1.0318971615401078 1.103590603468061 1.0242019223010097 1.1979773703194165 1.030153100060346 1.1739476375212297 1.0 15.512710969357597 AS(ph)PGLLPVANGNSLNK ddPTM_A459_Selumetinib_30min_R1 2 ASPGLLPVANGNSLNK 16 0 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 AS(1)PGLLPVANGNSLNK;AS(1)PGLLPVANGNSLNK 241.68 1.4138e-21 105718000.0 7120.0 5837.9 6775.0 7290.8 6778.5 5276.8 6193.299999999999 4983.8 3621.76 5519.9 True False 7285.882146891704 5154.395954033924 5854.992212411134 6017.598645266016 6165.385871841377 5223.720182951057 5726.134394745562 4851.6134343360845 6145.862197115546 6228.432933379173 1.1697777313849669 0.8275590359833029 0.9400425877644583 0.9661497056533656 0.9898775402718207 0.8386893202231176 0.9193539460075563 0.7789460826230477 0.9867429356393778 1.0 12.604653513139933 -6.746434354236535 24.96197404658514 0.8918435468060001 0.9674428478508773 0.10993113307861657 0.09939537421015382 507.54660557548226 844339.6874714553 0.03128488980586557 0.031165886496121866 1.792939543582668e-07 6.746434354236535 0.07559930104487722 AS(ph)PGLLPVANGNSLNK ddPTM_A459_Selumetinib_30min_R2 2 ASPGLLPVANGNSLNK 16 0 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 AS(1)PGLLPVANGNSLNK;AS(1)PGLLPVANGNSLNK 180.02 1.0357e-06 89030000.0 109065.0 100110.0 90203.0 110786.0 101348.0 83403.0 96459.0 84994.0 73178.0 87112.0 True False 103003.60392178762 107788.1150956146 84399.43718560076 95696.75568349035 88615.7581773843 94891.0061929471 100944.53462988253 85241.31846848581 87815.6447641561 84596.85021584229 1.217582021777193 1.2741386330649616 0.9976664257624505 1.1312094414783471 1.0475065909816745 1.1216848612074808 1.1932422350516643 1.0076181116790899 1.038048633490506 1.0 16.368316328206973 -5.251050039862974 24.997403863772043 1.0754353615678276 1.2458603468135945 0.563024123978462 0.06264425140671302 522.8744963126074 1258062.4411498674 0.016003820819615693 0.04134542965016796 5.609833352238202e-06 5.251050039862974 0.17042498524576688 AS(ph)PHDVLETIFVR ddPTM_A459_Selumetinib_30min_R2 1 ASPHDVLETIFVR 13 0 H0YEM7;O75143-4;O75143-3;O75143-2;O75143;O75143-5;H0YCL5 H0YEM7 ATG13 Autophagy-related protein 13 1 AS(1)PHDVLETIFVR 88.163 0.033575 0.0 1302.6 1213.2 2470.1 2150.1 2273.3 2291.7 2471.5 2055.5 2900.7 2416.4 True False 1230.206706720951 1306.2485389471576 2311.1764552415343 1857.2526708706187 1987.707730440145 2607.3608730186793 2586.4296471843422 2061.481164693658 3480.921052329773 2346.632253438812 0.5242435004113559 0.5566481654860702 0.984890773513694 0.7914545059836093 0.8470469659348242 1.1111075752060382 1.1021878879377565 0.8784849699703535 1.4833687925446122 1.0 11.19637605591833 -4.738208409921407 0.41013225232836387 1.1490010755860116 2.4401662634191806e-18 0.5976631533696417 0.1689307453893713 4.000538983597736 0.5157851535083874 0.13236360045591078 2.2891778783720866 1.827223154985372e-05 4.738208409921407 -1.1490010755860116 AS(ph)PIKMDLAPSK ddPTM_A459_Selumetinib_30min_R1 2 ASPIKMDLAPSK 12 1 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 AS(0.998)PIKMDLAPS(0.002)K;AS(1)PIKMDLAPSK 129.38 0.011002 206970000.0 4643.3 5594.6 4166.6 4114.2 4036.8 3725.1000000000004 4867.299999999999 4252.4 2186.35 4787.4 True False 4751.479855710992 4939.5816311410235 3600.7986054955313 3395.7322030989 3671.6721527549257 3687.628876120186 4500.155642314288 4139.612538258107 3710.0762653139795 5401.9094232249645 0.8795926557528868 0.9144140051485852 0.6665788563603567 0.6286170198447408 0.6796989481106332 0.6826528523906006 0.833067585873677 0.7663239447259631 0.6868083069595504 1.0 12.399253734253561 -11.143654421845516 10.438028142927443 1.0000278894012147 0.7466063452339872 0.39737827354619304 0.0928318014871594 6.624372640030846e-05 2.4066913089706163e-06 0.09882533365266448 0.023966036923874286 7.183656840800646e-12 11.143654421845516 -0.2534215441672275 AS(ph)PLLSDK ddPTM_A459_Selumetinib_30min_R2 2 ASPLLSDK 8 0 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;A0A590UJM5 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 AS(1)PLLSDK;AS(1)PLLSDK 82.029 0.042305 23262000.0 111985.0 88588.0 100057.0 117330.0 101984.0 88362.0 103968.0 88726.0 66740.0 92113.0 True False 105761.32201147357 95382.41474468396 93619.44155382444 101349.45159446061 89171.85817147227 100533.0634296273 108802.7180086836 88984.17797062003 80089.8648714065 89453.45835168377 1.1823055694020894 1.0662797895380485 1.0465715163941702 1.1329852804126148 0.9968519922493728 1.1238588790428243 1.2163053280838931 0.9947539157265582 0.8953244105614725 1.0 16.448849638801214 -7.985358082550267 24.034177633038116 0.9467878370025213 1.1026101070699925 0.5234849107793219 0.06463524153532732 108.60340555558477 178268.37318126136 0.03531664111616188 0.016952599867985516 1.0342890276359534e-08 7.985358082550267 0.15582227006747118 AS(ph)PLPSGLLTPPQSGK ddPTM_A459_Selumetinib_30min_R2 2 ASPLPSGLLTPPQSGK 16 0 I3L413;C9J2U0;P24864-2;P24864-3;P24864 I3L413 CCNE1 G1/S-specific cyclin-E1 1 AS(1)PLPSGLLTPPQSGK;AS(0.999)PLPS(0.001)GLLTPPQSGK 159.14 6.3751e-05 9659400.0 62426.0 43059.0 44005.0 50038.0 62545.0 50771.0 52938.0 64573.0 61559.0 51611.0 True False 58956.61283107792 46361.48684349297 41173.766209021356 43222.738079635405 54687.53794060563 57764.24439674973 55399.72189465698 64760.896739364354 73872.5201021714 50120.856328517846 1.1762890171837046 0.9249939095137553 0.8214896796484747 0.8623703034188277 1.0911133996226123 1.1524991516133163 1.105322732946515 1.292094778167559 1.4738878286111663 1.0 15.61312344325855 -6.878318537278237 1.3194148790845113 1.2568066256337078 0.9408760243824963 0.4008721069329281 0.14666663011684564 0.41143342027673313 1.4881575087838244 0.07615735156736585 0.061844519085761836 1.3233705408629414e-07 6.878318537278237 -0.31593060125121153 AS(ph)PNGSISSAGNSSR ddPTM_A459_Selumetinib_30min_R2 2 ASPNGSISSAGNSSR 15 0 E9PKU9;B7Z503;Q9BSF8;Q9BSF8-2 E9PKU9 BTBD10 BTB/POZ domain-containing protein 10 1 AS(0.999)PNGS(0.001)ISSAGNSSR;AS(0.997)PNGS(0.002)IS(0.001)SAGNSSR 122.16 0.0015912 5945400.0 4888.4 4841.1 4633.1 5945.700000000001 5865.6 6789.2 6956.4 8922.8 6788.8 5419.299999999999 True False 4616.7222978156715 5212.396803410061 4335.011390137867 5135.885403095413 5128.710888870676 7724.350673778599 7279.886383845092 8948.763870750936 8146.749694920661 5262.8307279676155 0.8772317667907483 0.990416958636055 0.8237033669163722 0.9758788888653415 0.9745156464211926 1.467717863835147 1.3832643989780034 1.700370833360765 1.5479786669989952 1.0 12.361623277849423 -6.738064004209996 4.965742181206813 1.4641027273697187 0.9232595570980663 0.6613988478672521 0.17464510752359963 0.10441143576477772 6.559567421553259 0.057800288607689085 0.055419610223740284 1.8278308194694454e-07 6.738064004209996 -0.5408431702716524 AS(ph)PNLIGATGANSLGK ddPTM_A459_Selumetinib_30min_R1 2 ASPNLIGATGANSLGK 16 0 Q02078-3;Q02078-5;Q02078;Q02078-8;Q02078-7;Q02078-4;Q02078-6;Q02078-2 Q02078-3 MEF2A Myocyte-specific enhancer factor 2A 1 AS(1)PNLIGATGANSLGK;AS(1)PNLIGATGANSLGK 149.42 0.00025968 41331000.0 1614.8200000000002 2206.0 2316.32 2652.0 2325.8999999999996 1668.06 2102.1 1959.52 1118.26 1560.3899999999999 True False 1652.4421641072558 1947.720494458423 2001.7764666350054 2188.8779842055023 2115.522755670998 1651.2808308773012 1943.5369045895798 1907.5471641819984 1897.6055455210796 1760.681255985712 0.9385243118193709 1.1062311749141658 1.1369329115248161 1.2431994585982378 1.2015364782688216 0.9378647187067581 1.1038550549579724 1.0834142509877882 1.0777677896381712 1.0 10.781918039923994 -6.741809472851105 24.983728615688182 1.0497483506788858 1.1314242227075892 0.1874307358057321 0.08667395844687739 466.417487850041 593626.1782650272 0.030280083438980986 0.030238723161265673 1.8121349108583785e-07 6.741809472851105 0.08167587202870341 AS(ph)PNLIGATGANSLGK ddPTM_A459_Selumetinib_30min_R2 2 ASPNLIGATGANSLGK 16 0 Q02078-3;Q02078-5;Q02078;Q02078-8;Q02078-7;Q02078-4;Q02078-6;Q02078-2 Q02078-3 MEF2A Myocyte-specific enhancer factor 2A 1 AS(1)PNLIGATGANSLGK;AS(0.999)PNLIGAT(0.001)GANSLGK 190.96 1.0373e-06 20314300.0 60822.0 58076.0 54357.0 54166.0 60432.0 45534.0 47713.0 51197.0 48797.0 46809.0 True False 57441.75672975714 62530.24245622744 50859.72979942678 46788.49735843818 52839.99189106533 51805.89518350244 49931.74904151587 51345.97479388041 58557.76350209811 45457.5025456122 1.263636440917974 1.3755758445700883 1.1188412682459614 1.0292799810436233 1.1624042002317552 1.139655552601471 1.0984270196413495 1.1295379622397796 1.2881869927486902 1.0 15.472230803607646 -5.270902109807667 24.58426790007261 1.1235108355784058 1.3196061426425658 0.51301475528054 0.07744579578553198 362.99950338994637 943078.3512244531 0.01974419890152317 0.042000913041725 5.35917439958266e-06 5.270902109807667 0.19609530706416 AS(ph)PNPVAMETR ddPTM_A459_Selumetinib_30min_R2 1 ASPNPVAMETR 11 0 H7BXF5;A0A2R8YDB8;Q9H0E3;Q9H0E3-3 H7BXF5 SAP130 Histone deacetylase complex subunit SAP130 1 AS(1)PNPVAMETR 89.74700000000001 0.028801 5640700.0 15658.0 10994.0 17043.0 25410.0 25401.0 14697.0 12561.0 21378.0 19111.0 16702.0 True False 14787.791043940302 11837.204448718307 15946.471935015357 21949.114165305084 22209.899292178816 16721.378343917422 13145.111389149315 21440.206440681573 22933.734005955215 16219.769862992467 0.9117139866257035 0.7298010112786151 0.9831503202397048 1.3532321574663564 1.3693103835494986 1.0309257458744492 0.8104376017776683 1.3218563901822193 1.4139370780026626 1.0 13.985465729321964 -5.5392196324992895 6.313076553659779 1.1844181341269984 0.8277844281874812 0.3871099117451091 0.18668355463613226 0.1605252749719073 25.05493428326397 0.05441130605752585 0.09900391409591017 2.8892183700453135e-06 5.5392196324992895 -0.35663370593951715 AS(ph)PNSDEDKPEVPPR ddPTM_A459_Selumetinib_30min_R2 3 ASPNSDEDKPEVPPR 15 1 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 AS(0.952)PNS(0.048)DEDKPEVPPR;AS(0.773)PNS(0.227)DEDKPEVPPR;AS(0.648)PNS(0.352)DEDKPEVPPR 93.342 0.0069141 25873700.0 66272.0 54683.8 58904.0 60359.0 65389.0 48786.0 52711.1 61167.0 48700.0 53535.0 True False 62588.86754783567 58877.871623869556 55114.18076982604 52138.000074917305 57174.2492349231 55505.82866478566 55162.27059506312 61344.98584325801 58441.36079169164 51989.30544936547 1.2038796634587385 1.132499676903996 1.0601061178534883 1.0028601002507458 1.099730968527892 1.067639357460643 1.0610311124234566 1.1799539407773858 1.1241035110309388 1.0 15.665927261226674 -4.924459953292779 2.958068976146921 1.0788242029367734 1.2077566506030304 0.3889341705944226 0.050629818128731297 0.34384563830844317 5.2608922257804895 0.013824184237439915 0.09047777137689322 1.1899810533857648e-05 4.924459953292779 0.128932447666257 AS(ph)PNVEAPQPHR ddPTM_A459_Selumetinib_30min_R2 2 ASPNVEAPQPHR 12 0 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851;A0A494BZW2 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 AS(1)PNVEAPQPHR;AS(1)PNVEAPQPHR 122.75 0.0017081 2754500.0 23915.0 18200.3 24768.4 26461.0 25688.0 22814.0 21071.6 26120.0 24444.0 21746.1 True False 22585.90003933021 19596.204486811694 23174.828109794915 22856.96615222895 22460.843786366277 25956.4214151277 22051.47115258329 26196.004875601226 29333.483022425273 21118.233589846765 1.0694975952055512 0.9279282002180886 1.0973847794228833 1.0823332384777737 1.0635758758329585 1.229100024142504 1.0441910806017984 1.2404448868391982 1.3890121490335365 1.0 14.366201546739003 -6.441769111049529 0.792775544224791 1.2037067762737161 1.0082525445543344 0.2527007230436433 0.11042186406561043 0.8506285615066773 1.1817225862439402 0.06494059734298624 0.0895484921486321 3.616020541889864e-07 6.441769111049529 -0.1954542317193817 AS(ph)PPAESMSVYR ddPTM_A459_Selumetinib_30min_R2 2 ASPPAESMSVYR 12 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 AS(1)PPAESMSVYR;AS(1)PPAESMSVYR 124.48 0.0030405 94935000.0 43394.0 33533.0 42292.0 46049.0 49592.0 33140.0 41550.0 40532.0 36103.0 43461.0 True False 40982.335199945446 36104.873274410646 39570.97876404798 39777.046761044214 43361.8096018949 37704.73418503253 43482.15732976304 40649.941409566156 43324.608802103554 42206.16800476089 0.971003460805127 0.8554406851230367 0.9375638830699896 0.9424462973411216 1.0273808699478155 0.893346540742088 1.0302322950725642 0.9631279817912114 1.0264994632352433 1.0 15.365166229184101 -6.242043715551927 0.6082740140747221 1.0013639622388244 0.9045042715433236 0.2955438819487327 0.04717490956363655 1.206603322649005 0.9252070689345123 0.03192542460923484 0.06442353082545557 5.727383769389348e-07 6.242043715551927 -0.09685969069550082 AS(ph)PPGDLQNPK ddPTM_A459_Selumetinib_30min_R1 4 ASPPGDLQNPK 11 0 O00273 O00273 DFFA DNA fragmentation factor subunit alpha 1 AS(1)PPGDLQNPK;AS(1)PPGDLQNPK;AS(1)PPGDLQNPK;AS(1)PPGDLQNPK 148.13 0.00065431 72899300.0 7436.1 9476.5 6479.6 6579.4 6930.0 6508.200000000001 7438.700000000001 7264.9 4179.37 6824.200000000001 True False 7609.346661868175 8366.986974494677 5599.705909895081 5430.431300634117 6303.182723590872 6442.733416972797 6877.592870068268 7072.211252279027 7092.085640892488 7700.152543337053 0.9882072620045101 1.0866001585559024 0.7272201269233959 0.7052368469418275 0.8185789421853753 0.836702049824675 0.8931761846743482 0.9184507985362725 0.9210318368340994 1.0 12.910671311162613 -8.303626653268408 1.1044412765607226 0.993081423319705 0.858097280661901 0.13296068195750743 0.10647434459043525 1.0875138195924614 2.74350627326499 0.11278940427097157 0.03731876035801741 4.9701940685418794e-09 8.303626653268408 -0.1349841426578039 AS(ph)PPGDLQNPK ddPTM_A459_Selumetinib_30min_R2 3 ASPPGDLQNPK 11 0 O00273 O00273 DFFA DNA fragmentation factor subunit alpha 1 AS(1)PPGDLQNPK;AS(1)PPGDLQNPK;AS(1)PPGDLQNPK 124.38 0.0035905 93330000.0 89401.0 63504.0 86002.0 81703.0 93280.0 76541.0 85163.0 93106.0 83468.0 81202.0 True False 84432.45032055862 68374.55260245656 80468.72495189765 70574.91045446366 81561.33246621945 87083.82797998111 89123.24824728296 93376.923045472 100163.93229077883 78857.48727186663 1.0706966864093947 0.8670648148695199 1.0204322726449064 0.8949677817041239 1.0342877422029835 1.104319082343489 1.1301811829233717 1.184122475568472 1.2701892458918551 1.0 16.26696012045204 -6.769525873986564 1.8562276757629506 1.1612062985477196 0.9598239190128494 0.49436877015249003 0.08317476373231236 0.25645757095652283 1.8240701470885399 0.03267498443507771 0.029733246552628153 1.7000986637522264e-07 6.769525873986564 -0.20138237953487026 AS(ph)PPLFQSR ddPTM_A459_Selumetinib_30min_R2 1 ASPPLFQSR 9 0 O15055 O15055 PER2 Period circadian protein homolog 2 1 AS(1)PPLFQSR 80.916 0.045196 7730100.0 16455.0 19155.0 21923.0 25755.0 27788.0 21191.0 16946.0 21005.0 20180.0 21403.0 True False 15540.49697458409 20624.126906967365 20512.49804795763 22247.124570146872 24297.023012128073 24109.86789725483 17734.02257786196 21066.121072435053 24216.563876310825 20785.03977832762 0.747677037923595 0.992258236064189 0.9868876012133415 1.0703431317626708 1.1689668757556273 1.1599625574156456 0.8532109039479959 1.013523250236957 1.165095863880002 1.0 14.343257888538488 -4.221875120715519 1.2722690725386674 1.0578529125658758 1.0299740644111e-16 0.4955922455030589 0.09245844268943132 4.553665108394155 2.3794163827588677 0.028745655408871227 8.923454789234079 5.9996356808622415e-05 4.221875120715519 -1.0578529125658758 AS(ph)PPPQGPLPGPPGALHR ddPTM_A459_Selumetinib_30min_R1 4 ASPPPQGPLPGPPGALHR 18 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 AS(1)PPPQGPLPGPPGALHR;AS(1)PPPQGPLPGPPGALHR;AS(1)PPPQGPLPGPPGALHR;AS(1)PPPQGPLPGPPGALHR 188.34 1.3678000000000002e-10 157909000.0 9723.6 11553.2 11604.199999999999 11975.3 9414.099999999999 10714.9 9789.1 9642.599999999999 5684.18 7645.3 True False 9950.140961168003 10200.545973063034 10028.413377307934 9884.038659221778 8562.596317194351 10607.117834350796 9050.70030575037 9386.84692442094 9645.6383039186 8626.648726528341 1.1534190479519246 1.1824459644096441 1.1624923762652974 1.1457564776953024 0.9925750530287598 1.2295757217669234 1.049156003990055 1.0881220763695716 1.1181211394706152 1.0 13.07458449590653 -3.859638579316333 0.016758817301209476 7.539188518623856e-07 2.367756858685475 0.3448165450841201 0.060330933228397325 3171.4273133865827 6.465449091699832 389.34988801809226 533.3544787746364 0.00013815335011130197 3.859638579316333 2.3677561047666233 AS(ph)PPPQGPLPGPPGALHR ddPTM_A459_Selumetinib_30min_R2 1 ASPPPQGPLPGPPGALHR 18 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 AS(1)PPPQGPLPGPPGALHR 84.41 0.0080228 36933000.0 6480.4 6047.5 2230.9 8800.4 8283.6 7017.6 971.29 7528.1 5875.0 7364.5 True False 6120.245311096611 6511.323804222664 2087.366322820265 7601.770338463229 7242.940111676411 7984.210700569837 1016.456909574623 7550.005524655953 7050.164161215368 7151.867749731055 0.8557548217144763 0.9104368302206821 0.29186310427772666 1.0629070061801817 1.0127340668385236 1.11638119998375 0.1421246791948644 1.0556690628038907 0.9857794366346454 1.0 12.80410434353074 AS(ph)PQPALTVK ddPTM_A459_Selumetinib_30min_R1 1 ASPQPALTVK 10 0 Q8N9M1-2;Q8N9M1;Q8N9M1-3;A0A2R8Y6U9;J3QS80 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 AS(0.997)PQPALT(0.003)VK 88.101 0.038217 0.0 1619.2 1941.8 1433.6 1623.5 1391.0 1559.1 1562.1 1679.4 869.7 1496.3 True False 1656.9242095852603 1714.4531532816713 1238.9249942011222 1339.9862018693946 1265.1842956009964 1543.4168695495357 1444.2695393460751 1634.8568565399921 1475.8173796252054 1688.3646801962477 0.9813781519006114 1.01545191829196 0.7338017720538405 0.79365922397384 0.749354870094734 0.9141489914193989 0.855425108264051 0.9683078991855977 0.8741105502477481 1.0 10.72141083887683 -8.392331628162557 0.8469304609126154 0.9902900277748304 0.8585087992326339 0.14804088965106577 0.09127656349265217 1.219656917029848 1.9440229082795726 0.09452984376203838 0.034582793060273016 4.05199006487457e-09 8.392331628162557 -0.13178122854219654 AS(ph)PQPALTVK ddPTM_A459_Selumetinib_30min_R2 3 ASPQPALTVK 10 0 Q8N9M1-2;Q8N9M1;Q8N9M1-3;A0A2R8Y6U9;J3QS80 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 AS(1)PQPALTVK;AS(1)PQPALTVK;AS(0.989)PQPALT(0.011)VK 109.72 0.0069568 3136800.0 80509.0 63831.0 65916.0 77372.0 72364.0 63035.0 64550.0 66016.0 62053.0 71439.0 True False 76034.63208306232 68726.63245098593 61675.03632391436 66833.80012585544 63272.98737763187 71717.49907524227 67551.70290339856 66208.09563046294 74465.33390568462 69376.37044918683 1.0959730465973596 0.990634592239489 0.8889919712517516 0.9633510616529928 0.9120250449535229 1.0337453316006227 0.9736990053821755 0.9543320759184941 1.0733529791706975 1.0 16.082156744936924 -8.251348430653426 24.64529821304465 1.0366764921441411 0.9733567792970347 0.14706671959054218 0.057455682619813306 940.2143185257836 2296318.5798959434 0.040376618878489645 0.01487994270220745 5.6059803267945764e-09 8.251348430653426 -0.06331971284710647 AS(ph)PS(ph)PPAHAEHGGVLAR ddPTM_A459_Selumetinib_30min_R1 1 ASPSPPAHAEHGGVLAR 17 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 2 AS(1)PS(1)PPAHAEHGGVLAR 77.469 0.043318 0.0 889.02 1029.4 1131.1 1168.6 1148.5 1143.2 1040.5 873.21 440.89 659.08 True False 909.7324362682107 908.8773694449231 977.5028326875617 964.5259473388201 1044.6183777841445 1131.7004459425507 962.0142472886441 850.0496342141763 748.1581286684575 743.6793379828529 1.223285883853864 1.2221361049375816 1.3144144025016602 1.2969648315831779 1.4046623651230585 1.5217586238339789 1.2935874350065988 1.143032474883383 1.0060224756247134 1.0 9.538536879355277 -7.9336457032565075 2.5285431306899206 1.0075742435648662 1.3318550614470255 0.7188608676402802 0.08221668027647246 0.17744696778629554 2.1894072347826454 0.0697897416427197 0.026052938743427904 1.1650761090467866e-08 7.9336457032565075 0.32428081788215923 AS(ph)PS(ph)PQPSSQPLQIHR ddPTM_A459_Selumetinib_30min_R2 1 ASPSPQPSSQPLQIHR 16 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 2 AS(1)PS(1)PQPSSQPLQIHR 79.462 0.045305 0.0 8281.6 6381.2 10119.0 11060.0 11687.0 7535.0 6621.9 7069.3 8532.0 6943.9 True False 7821.34182587151 6870.617521208043 9467.954556734165 9553.608920435818 10218.774576894375 8572.877854080278 6929.83147104592 7089.870492614388 10238.63840399822 6743.411564581096 1.1598493953642255 1.0188637391339244 1.404030358530003 1.4167322917994392 1.5153716303728482 1.271296846110983 1.0276447469770302 1.0513773962504414 1.5183172947318468 1.0 12.719262935725752 -7.0210894929338385 23.793124121939023 1.153024050707815 1.308541835548515 0.13165382137270498 0.18775839916709983 943.4237476652105 1064365.8624688608 0.0752792700135472 0.05902774551649573 9.525998462190481e-08 7.0210894929338385 0.1555177848406999 AS(ph)PSKPASAPASR ddPTM_A459_Selumetinib_30min_R1 1 ASPSKPASAPASR 13 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 AS(0.997)PS(0.003)KPASAPASR 184.0 0.00057943 52024000.0 2039.4 2511.8 2739.3 2443.2 2445.0 2231.7 2440.7 2141.0 1350.2 2443.8 True False 2086.91405201839 2217.7172882958594 2367.318105897832 2016.5409845440745 2223.8501816998114 2209.2511242214737 2256.5960339811554 2084.213725051879 2291.1907852937256 2757.4855346278077 0.7568177695989516 0.8042534622380879 0.8585060832304099 0.731297031016432 0.8064775512956502 0.8011832143734774 0.8183528093414786 0.7558384981095454 0.8308985691933937 1.0 11.429137602328078 -8.561253804813363 17.19787565861166 1.0000000009267354 0.7939057396691094 0.7662932599106929 0.03439975853994441 85.43623251626822 38289.02504150191 0.032116072174770686 0.008292331700737808 2.746288733185202e-09 8.561253804813363 -0.20609426125762598 AS(ph)PSKPASAPASR ddPTM_A459_Selumetinib_30min_R2 1 ASPSKPASAPASR 13 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 AS(0.601)PS(0.399)KPASAPASR 151.07 0.002257 88086000.0 61581.0 51649.0 84001.0 98269.0 121760.0 73657.0 64946.0 90423.0 93372.0 70134.0 True False 58158.574548274904 55610.312222289576 78596.46711337351 84884.59267651959 106463.42025178914 83802.58315832661 67966.11768805764 90686.11595966642 112049.00903166003 68109.04918998426 0.8539037798934269 0.8164893341436826 1.1539798022159362 1.2463041796361216 1.56313179405601 1.230417751458644 0.9979014315479882 1.33148409848896 1.6451412898029023 1.0 16.055558871681015 -5.407649583126333 2.5409956736240074 1.29790174865721 0.8235962822710123 0.45478333884417854 0.1950235349625275 0.2628850955347412 3.2481021998242805 0.05583303312534887 0.1466202668282364 3.91156378761582e-06 5.407649583126333 -0.47430546638619764 AS(ph)PSTAGETPSGVK ddPTM_A459_Selumetinib_30min_R1 1 ASPSTAGETPSGVK 14 0 A0A087WW69;F8W8L6;A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WW69 EIF2B4 Translation initiation factor eIF-2B subunit delta 1 AS(0.997)PS(0.003)TAGETPSGVK 160.87 0.00028748 13809000.0 3830.6 5005.4 3144.0 2973.6 3772.9 3788.0 4728.3 4254.7 2090.5 4070.1 True False 3919.8455269499104 4419.365441052671 2717.0620687558085 2454.3165813851733 3431.641861159597 3749.8961592288138 4371.640524223829 4141.851534786657 3547.425815920999 4592.536981131288 0.8535250871260982 0.9622928370985139 0.5916255176428672 0.534414113913264 0.7472213888007222 0.8165195347659662 0.9519009955031337 0.9018656903153315 0.7724327164910832 1.0 12.16507562326162 -6.949540080790437 3.3572467187588315 0.8978196739159403 0.7312914114856933 0.28561167853438174 0.1249922848519207 0.3693771719451474 8.562263969940505 0.05294661379346367 0.04465959572865575 1.1232073047282359e-07 6.949540080790437 -0.166528262430247 AS(ph)PSTAGETPSGVK ddPTM_A459_Selumetinib_30min_R2 2 ASPSTAGETPSGVK 14 0 A0A087WW69;F8W8L6;A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WW69 EIF2B4 Translation initiation factor eIF-2B subunit delta 1 AS(0.997)PS(0.001)T(0.002)AGETPSGVK;AS(0.998)PS(0.002)TAGETPSGVK 223.06 4.1012e-09 32102000.0 135866.0 85755.0 103267.0 136424.0 139444.0 135102.0 159184.0 157547.0 172773.0 118551.0 True False 128315.11163469126 92332.13275421473 96622.9136486085 117842.8158554735 121925.79807482321 153711.07416615158 166586.37141711215 158005.43568669003 207332.4276809634 115128.1245975103 1.1145418383499504 0.8019945871350662 0.8392642022651173 1.023579740115231 1.059044421170567 1.3351305313408681 1.4469650400325784 1.3724312476997214 1.800884261823953 1.0 16.81288078628142 -6.697550791550502 1.6627389945889879 1.4424532924697708 0.9194366460661394 0.5358914591059749 0.19892537135111624 0.2577329764779333 1.4744828600741384 0.07938955798896823 0.07599419317592858 2.0065464069465575e-07 6.697550791550502 -0.5230166464036314 AS(ph)PTGTPSR ddPTM_A459_Selumetinib_30min_R1 2 ASPTGTPSR 9 0 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 AS(0.994)PT(0.005)GT(0.001)PSR;AS(0.991)PT(0.007)GT(0.002)PSR 104.42 0.01436 7336100.0 1652.8400000000001 4778.9 1847.2199999999998 2258.27 2267.3 2875.6000000000004 2902.0 2363.4 1177.76 2562.2 True False 1691.3479561332135 4219.384166349663 1596.3776700531496 1863.905537478039 2062.2231153243265 2846.674074835897 2683.099803586396 2300.714954594867 1998.5726998130199 2891.0833279414705 0.5850222094212342 1.4594474415768497 0.5521728324550969 0.644708341493979 0.7133046271594963 0.9846392344778266 0.9280603494389197 0.795796832405048 0.6912885147575658 1.0 11.49739447600055 -10.786772171854084 5.300012371261488 1.0000216240590194 0.8276897296637717 0.043816113244341426 0.2519545374428052 6.326016249514551e-05 8.786382155653424e-06 0.23971837401589083 0.0581329543381725 1.6339088613918638e-11 10.786772171854084 -0.17233189439524765 AS(ph)PTGTPSR ddPTM_A459_Selumetinib_30min_R2 1 ASPTGTPSR 9 0 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 AS(0.764)PT(0.18)GT(0.053)PS(0.003)R 94.409 0.023293 17922000.0 11305.0 11527.0 11280.0 13098.0 14659.0 12410.0 15327.0 25135.0 12476.0 20137.0 True False 10676.71335750065 12411.083834853187 10554.25708073539 11314.029804689726 12817.405366877263 14119.36485323638 16039.735869874332 25208.138688676732 14971.5486085656 19555.592487790662 0.5459672655874042 0.6346564975007494 0.5397053087153884 0.5785572496335014 0.6554342638751386 0.7220116118727502 0.8202122170365628 1.289050112105536 0.7655891079706706 1.0 14.255293626499794 -7.254817780300221 1.90451957031932 1.0205239489810225 0.5913930615865218 0.6676927786756774 0.12841782641946958 0.19187295949644173 1.3587722747146134 0.06266340910165559 0.039665909256614125 5.561375504963412e-08 7.254817780300221 -0.42913088739450067 AS(ph)PTLDFTER ddPTM_A459_Selumetinib_30min_R1 2 ASPTLDFTER 10 0 J3KQV8;O43426;A0A0D9SGJ6 J3KQV8 SYNJ1 Synaptojanin-1 1 AS(0.956)PT(0.026)LDFT(0.018)ER;AS(0.998)PT(0.002)LDFTER 121.29 0.004823600000000001 45630000.0 3317.6000000000004 4351.7 3656.7 3599.3999999999996 3837.8 3129.9 4278.0 3691.1000000000004 2396.42 3421.5 True False 3394.893625074147 3842.2009409495577 3160.140224815319 2970.832359106066 3490.671667618621 3098.416047721825 3955.3070157624425 3593.200037617464 4066.5497124082303 3860.6828532322797 0.8793505589903196 0.995212786705013 0.8185443728353793 0.7695095588125805 0.9041591346194433 0.8025564817187038 1.02450969585625 0.9307161904296617 1.0533239499337772 1.0 11.914640329524163 -7.270176879617675 24.985450132482878 0.9963638139005433 0.8634283873719137 0.5284922072628521 0.06494600360047449 580.1653984677557 1659013.671973134 0.027864717472019046 0.01910630061365623 5.3681311839568125e-08 7.270176879617675 -0.13293542652862955 AS(ph)PTSDIESVER ddPTM_A459_Selumetinib_30min_R2 1 ASPTSDIESVER 12 0 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 AS(0.985)PT(0.009)S(0.006)DIESVER 128.35 0.0024629 9148900.0 12291.0 19520.0 12411.0 20096.0 18350.0 14539.0 21552.0 14331.0 15028.0 17070.0 True False 11607.915424771389 21017.12123330737 11612.489772075089 17358.890132466393 16044.708948918593 16541.615278098623 22554.21070447781 14372.700837375234 18034.019917403322 16577.144746813658 0.7002361143647842 1.2678372273576928 0.7005120573799152 1.0471580237485105 0.967881332640387 0.9978567196427561 1.360560642315259 0.8670190830141514 1.087884565939481 1.0 14.016907917484234 -7.01089354527507 24.655391485566643 1.0837020797804917 0.9516059500198879 0.10659843378353351 0.19137867198977893 1079.1991667525685 2442554.173215827 0.06649527878515765 0.05489891506974167 9.752286575067044e-08 7.01089354527507 -0.1320961297606038 AS(ph)PTSTEEEQVMLR ddPTM_A459_Selumetinib_30min_R1 2 ASPTSTEEEQVMLR 14 0 Q96PE3-3;Q96PE3;Q96PE3-2;Q96PE3-4 Q96PE3-3 INPP4A Type I inositol 3,4-bisphosphate 4-phosphatase 1 AS(0.994)PT(0.006)STEEEQVMLR;AS(0.97)PT(0.024)S(0.005)T(0.001)EEEQVMLR 194.77 0.00012177 12108500.0 1085.42 1458.37 1155.09 1167.89 1467.49 1265.76 1252.02 1136.51 672.4 1010.3299999999999 True False 1110.7081741403365 1287.6233624221813 998.235122455199 963.9399355104689 1334.7557886064035 1253.0276036181265 1157.5791233929144 1106.3660628952405 1141.0136898470612 1140.015696947587 0.9742920006402351 1.1294786254871898 0.8756327874502008 0.8455497043518223 1.1708222897107792 1.0991318864934325 1.015406302292463 0.970483183571556 1.0008754203140766 1.0 10.15483797374731 -4.469851409500422 17.653824070775112 1.0118510724593999 0.6500937377392312 0.013253744756903107 0.09742815334627249 10244231.419635791 76428143.30788569 0.02561342243597414 131979360.77240628 3.389601088827553e-05 4.469851409500422 -0.3617573347201687 AS(ph)PTSTEEEQVMLR ddPTM_A459_Selumetinib_30min_R2 2 ASPTSTEEEQVMLR 14 0 Q96PE3-3;Q96PE3;Q96PE3-2;Q96PE3-4 Q96PE3-3 INPP4A Type I inositol 3,4-bisphosphate 4-phosphatase 1 AS(0.843)PT(0.148)S(0.007)T(0.002)EEEQVMLR;AS(0.733)PT(0.037)S(0.115)T(0.115)EEEQVMLR 155.06 0.00033215 8081400.0 18882.0 17840.1 19270.8 18791.9 19598.0 13252.9 16200.3 17458.2 12934.4 17598.699999999997 True False 17832.614030634875 19208.37830503723 18030.937708460613 16232.410802164366 17135.924031657036 15078.366677152015 16953.646050285446 17509.000471639407 15521.64141733176 17090.57980408608 1.0434177327542387 1.1239161295420077 1.0550220013103189 0.9497870164874957 1.0026531708163648 0.882261857116575 0.991987764290601 1.0244825320351794 0.9081986448242552 1.0 14.060913721343523 -5.655117160549401 4.441071396271733 0.9658804787511591 1.0848481507296732 0.5491035200735228 0.04540177805003712 0.15013406084145908 5.119382084843772 0.012210215713911308 0.021743469893408224 2.2124977588458536e-06 5.655117160549401 0.1189676719785141 AS(ph)PVAALK ddPTM_A459_Selumetinib_30min_R2 2 ASPVAALK 8 0 H9KVB4;O15417;O15417-2 H9KVB4 TNRC18 Trinucleotide repeat-containing gene 18 protein 1 AS(1)PVAALK;AS(1)PVAALK 96.665 0.020894 18580000.0 145530.0 99641.0 133543.0 150365.0 161687.0 146089.0 156091.0 160563.0 143811.0 123124.0 True False 137442.02520274822 107283.14430368738 124950.98877062472 129885.02760590702 141374.43355988004 166211.43368609596 163349.54078844874 161030.21174736458 172577.21841507105 119569.09020542965 1.1494778873587763 0.8972481443102562 1.0450107846095384 1.0862759546196574 1.1823660556167734 1.3900869647877296 1.3661519085559708 1.3467545121460844 1.4433263489633401 1.0 16.867484961207246 -6.4045355708728255 2.1208971347237604 1.3340840727745837 1.024624397290012 0.4783097397105781 0.12821063269239363 0.23802009745769243 2.111299379306997 0.04266217253413065 0.04985441117139883 3.9397115813070305e-07 6.4045355708728255 -0.30945967548457176 AS(ph)PVGDGNFR ddPTM_A459_Selumetinib_30min_R2 2 ASPVGDGNFR 10 0 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5;H0YFC4 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 AS(1)PVGDGNFR;AS(1)PVGDGNFR 108.98 0.010346 39607000.0 142465.0 122938.0 128551.0 113973.0 142646.0 138989.0 147715.0 145883.0 104710.0 129105.0 True False 134547.36563258115 132366.94929202602 120280.16861574634 98449.68078560884 124725.53420858001 158133.47313347892 154584.04019171966 146307.4953777693 125654.9258418489 125377.40319492525 1.0731388767352221 1.0557480528308125 0.9593448703730592 0.7852266698533255 0.994800745830317 1.2612597573713307 1.2329497680805097 1.1669367178573946 1.0022134981252737 1.0 16.93591782866747 -6.621711561831326 7.644291357723939 1.14872568074013 0.9637645776321322 0.3494333661838389 0.10773097124107593 0.2549615953206056 17.34726981918057 0.037764413991547695 0.03772858121819126 2.389397682708921e-07 6.621711561831326 -0.18496110310799785 AS(ph)PVPAPSSGLHAAVR ddPTM_A459_Selumetinib_30min_R1 2 ASPVPAPSSGLHAAVR 16 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 AS(0.998)PVPAPS(0.001)S(0.001)GLHAAVR;AS(1)PVPAPSSGLHAAVR 113.43 0.0022733 34507000.0 2026.31 2333.8 1802.1799999999998 1963.1000000000001 2545.88 1994.6000000000001 2449.16 1979.79 1038.3 1953.0900000000001 True False 2073.5190804870967 2060.557611045814 1557.4538546661393 1620.281436950914 2315.60560351162 1974.536134951898 2264.4178893699727 1927.2795379357578 1761.919265568417 2203.7881262076376 0.9408885799086717 0.9350071300146716 0.7067166921106273 0.7352255952749668 1.0507387602166647 0.8959736698235846 1.0275116116841365 0.8745303212302418 0.7994957612374446 1.0 11.105769813488264 -6.254788528350025 24.99730676512763 0.9371382988192237 0.82823127912351 0.2357268063543756 0.09853545711708402 898.209772533068 3375929.6808930053 0.03111663189568012 0.03923582298929414 5.561750104606965e-07 6.254788528350025 -0.1089070196957137 AS(ph)PVPAPSSGLHAAVR ddPTM_A459_Selumetinib_30min_R2 4 ASPVPAPSSGLHAAVR 16 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 AS(1)PVPAPSSGLHAAVR;AS(1)PVPAPSSGLHAAVR;AS(1)PVPAPSSGLHAAVR;AS(1)PVPAPSSGLHAAVR 177.39 1.1637e-06 32418600.0 10826.199999999999 8841.5 22074.3 29452.6 36348.3 22722.7 15355.109999999999 18630.3 18913.5 23747.1 True False 10224.523144712388 9519.61462009668 20654.0635706806 25441.105071431106 31781.901596075106 25852.54566886661 16069.153040573236 18684.511088587795 22696.728487344157 23061.459520624387 0.4433597594102127 0.41279324110354215 0.8956095581118446 1.103187118260167 1.378139209604311 1.1210281658776233 0.6967968799287064 0.8102050554032719 0.9841843907167263 1.0 14.493196201148596 -5.326814027738274 3.7637203410050173 1.0109821074345517 0.4194621038125315 0.6400488612700823 0.17271264868688588 0.15640164523177905 4.363612773911521 0.05355222863107627 0.12832547203601644 4.711790500624077e-06 5.326814027738274 -0.5915200036220203 AS(ph)PVSFQELNR ddPTM_A459_Selumetinib_30min_R1 2 ASPVSFQELNR 11 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 AS(1)PVSFQELNR;AS(0.998)PVS(0.002)FQELNR 124.48 0.0035592 28954000.0 3124.8 3859.8999999999996 4097.8 4415.8 4372.6 3718.2 3942.4 3719.0 2289.0 3226.7 True False 3197.601760197639 3407.981113581174 3541.341267604182 3644.6634248320743 3977.09910204523 3680.7982838554844 3645.021593955549 3620.3600389854923 3884.265818054613 3640.878375719593 0.8782500897371109 0.9360326717608665 0.9726612377993159 1.0010395977898419 1.0923460471977962 1.0109643618974231 1.0011379721617693 0.994364454228701 1.0668485506020005 1.0 11.830070832729076 -5.199405525154256 1.3199531790024734 1.02549381492583 0.8693107560816682 0.7113502333210527 0.030674876956640725 0.3956643432815713 0.9922553796344242 0.009815798813193883 0.06788410837577713 6.318216085191814e-06 5.199405525154256 -0.15618305884416173 AS(ph)PVSFQELNR ddPTM_A459_Selumetinib_30min_R2 3 ASPVSFQELNR 11 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 AS(0.977)PVS(0.023)FQELNR;AS(1)PVSFQELNR;AS(1)PVSFQELNR 184.11 2.7052e-05 36128300.0 22282.0 21846.3 12631.2 22277.0 22730.6 20922.0 20350.7 12752.400000000001 15860.3 18037.84 True False 21043.655641913276 23521.840963073908 11818.522343810724 19242.83417003153 19874.97881385771 23803.81558899368 21297.04787414703 12789.50737272653 19032.803173808355 17517.040691263344 1.2013248135233732 1.34279764360001 0.6746871547604062 1.0985208351790223 1.1346082460018712 1.358894804695286 1.2157902838445178 0.7301180375236166 1.0865307393674664 1.0 14.096471447830396 -7.737139418144154 24.998824502706814 0.9312430254459751 1.1418992471909013 0.18964952388621237 0.19645704918645404 381.66293355614016 392640.02681338775 0.09632905672297751 0.05558116248370094 1.831726303278092e-08 7.737139418144154 0.21065622174492615 AS(ph)QEANLLTLAQK ddPTM_A459_Selumetinib_30min_R2 2 ASQEANLLTLAQK 13 0 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2;H7C1L3 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 AS(1)QEANLLTLAQK;AS(0.995)QEANLLT(0.005)LAQK 88.78 0.02334 4199600.0 28258.7 27392.4 31524.0 33502.0 35046.0 27335.8 26644.1 29500.7 30217.3 29651.0 True False 26688.194582539 29493.308999551675 29495.78016073605 28938.969805826473 30643.20816478481 31101.058320314216 27883.103444282562 29586.542152896214 36261.60434190519 28794.898587449992 0.9268375959542645 1.0242546578165785 1.0243404772257656 1.0050033591172038 1.0641887857920913 1.0800891771110228 0.9683348374921928 1.0274924936110472 1.2593065480602006 1.0 14.813525620574943 -2.1535065430186067 0.37728915686643205 1.0728345976235563 1.7622175037001916e-16 0.2237959773003434 0.07458221909901185 70.20362123599332 1.5222381215981813 0.05838388502036503 51.035118869343 0.007022527636162754 2.1535065430186067 -1.072834597623556 AS(ph)QSRPNSSALETLGGEK ddPTM_A459_Selumetinib_30min_R2 1 ASQSRPNSSALETLGGEK 18 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 AS(0.492)QS(0.492)RPNS(0.013)S(0.003)ALETLGGEK 79.172 0.006775499999999999 21259000.0 26511.0 25287.0 28650.0 30767.0 28881.0 28647.0 30609.0 25855.0 24741.0 29450.0 True False 25037.624751941592 27226.43158947969 26806.69019176143 26576.481523964616 25252.710580584106 32592.864218425697 32032.37915058284 25930.233769474326 29689.891321298634 28599.701979710717 0.8754505473415022 0.9519830524386144 0.9373066268585145 0.9292572888633098 0.8829711092269058 1.1396225122047712 1.1200249279977583 0.9066609780713738 1.0381189056571751 1.0 14.803712493174318 -6.741226422694808 24.999995542121937 1.0399980261436181 0.9194140316348967 0.49269761840109005 0.06360045116086618 231.74230670418285 286625.2249501818 0.02214228870966921 0.022116101707137382 1.8145693767245468e-07 6.741226422694808 -0.12058399450872148 AS(ph)SCETYEYPQR ddPTM_A459_Selumetinib_30min_R1 1 ASSCETYEYPQR 12 0 Q9UQC2;Q9UQC2-2 Q9UQC2 GAB2 GRB2-associated-binding protein 2 1 AS(0.515)S(0.479)CET(0.006)YEYPQR 154.67 0.00043595 5360800.0 1385.4 1529.7 1676.5 2200.3 1593.5 1101.6 1506.5 1621.9 853.25 1507.4 True False 1417.6771244808651 1350.6020128617636 1448.8405083553155 1816.0589097463676 1449.3682063552749 1090.5189041727724 1392.8634921098908 1578.8819433263154 1447.902931085669 1700.8894733194024 0.8334916211305435 0.794056306448867 0.851813437076428 1.0677112994309996 0.8521236853366688 0.6411462480537021 0.8189029998472636 0.9282683960910282 0.8512622094485582 1.0 10.732073679940433 -8.956678846633865 1.1432262812397564 0.9992625363209416 0.8442390650396248 0.17046959219217483 0.10063945818967496 3.219393148262593 6.281771109119731 0.10547527608725271 0.03244712926157097 1.1048953691695947e-09 8.956678846633865 -0.15502347128131688 AS(ph)SFSGISVLTR ddPTM_A459_Selumetinib_30min_R2 2 ASSFSGISVLTR 12 0 Q15032-2;Q15032-4;Q15032;Q15032-3;H7C207;H7C1X4;H7BZ47 Q15032-2 R3HDM1 R3H domain-containing protein 1 1 AS(0.624)S(0.374)FS(0.003)GISVLTR;AS(0.791)S(0.205)FS(0.003)GISVLTR 166.7 0.00045948 26883000.0 89672.0 85877.0 94044.0 102831.0 116670.0 60766.0 81856.0 88554.0 68765.0 82747.0 True False 84688.38922545756 92463.48976192284 87993.3114273653 88825.24040663072 102012.87155696632 69135.96492117352 85662.4661945868 88811.67747909621 82519.92145463414 80357.87910747461 1.0538902988242274 1.1506462190005984 1.0950178427392128 1.1053706418487157 1.2694818814285684 0.8603507918459079 1.066012034489083 1.1052018602969234 1.0269051693645113 1.0 16.294151866946848 -6.753840549458202 24.99997454808369 1.0216639624312425 1.131903035913377 0.37288172647425744 0.07930565086227762 218.21617785559405 717924.6707840157 0.026562786061872387 0.02607940327218964 1.7626230719394074e-07 6.753840549458202 0.11023907348213458 AS(ph)SHS(ph)SQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 2 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.893)S(0.213)HS(0.889)S(0.005)QTQGGGSVTK;AS(0.999)S(0.003)HS(0.628)S(0.368)QT(0.002)QGGGSVTK 126.4 0.0044902 193299000.0 243183.0 189711.0 269065.0 321159.0 298084.0 219249.0 197109.0 213226.0 216090.0 273583.0 True False 229667.86239868033 204261.22368299036 251753.65083582184 277416.5901698228 260636.02301522892 249448.55960573902 206274.95906407386 213846.45235853558 259314.03805906925 265683.947936 0.8644401145906055 0.7688128141343126 0.9475681643230708 1.0441601471408768 0.9810002638097388 0.9388920992164272 0.7763922535273488 0.8048903745214165 0.9760244835022356 1.0 18.0193515403055 AS(ph)SHSS(ph)QTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 1 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.949)S(0.051)HS(0.008)S(0.988)QT(0.004)QGGGSVTK 95.988 0.033542 130270000.0 118040.0 105920.0 119090.0 159140.0 149320.0 93753.0 94330.0 106980.0 91083.0 123160.0 True False 111479.80935155925 114043.72341352014 111427.8790553883 137464.85746818755 130561.08666226298 106666.62474500173 98716.53191134898 107291.29408850762 109302.14507165624 119604.05079189021 0.9320738604876597 0.953510542982821 0.9316396753925302 1.1493327906374589 1.0916109094786255 0.8918312050366967 0.8253611082380036 0.8970540159646712 0.9138665818421219 1.0 16.86790672650131 -6.789336665019458 24.754618363061834 0.894172030444301 1.0116103475646783 0.32191385138316897 0.07602675886730698 234.8883526430774 208426.0779812366 0.02900549411016181 0.02558591530886348 1.624289118888746e-07 6.789336665019458 0.11743831712037722 AS(ph)SHSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 2 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.462)S(0.462)HS(0.073)S(0.002)QTQGGGSVTK;AS(0.44)S(0.44)HS(0.112)S(0.008)QTQGGGSVTK 139.39 0.00026606 286090000.0 18445.6 21716.1 15753.8 18116.3 37065.4 22807.8 27708.2 20234.7 5118.07 8846.0 True False 18875.346591110345 19173.568916459 13614.520489429151 14952.628290068682 33712.841114427865 22578.37423982549 25618.148166000195 19698.010024431238 8684.990980957085 9981.470267336768 1.8910387032737832 1.9209162981932966 1.3639794664300238 1.4980386545857343 3.377542607600538 2.2620289030675838 2.5665706033140916 1.9734577669274582 0.870111391242404 1.0 13.285036624389523 AS(ph)SHSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 5 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.438)S(0.438)HS(0.108)S(0.015)QT(0.001)QGGGSVTK;AS(0.801)S(0.195)HS(0.003)S(0.001)QTQGGGSVTK;AS(0.419)S(0.419)HS(0.13)S(0.03)QT(0.002)QGGGSVTK;AS(0.334)S(0.334)HS(0.166)S(0.166)QTQGGGSVTK;AS(0.381)S(0.381)HS(0.189)S(0.048)QT(0.001)QGGGSVTK 151.22 0.00013713 809481100.0 48558.1 44987.6 60504.3 97710.0 100635.0 59022.399999999994 58031.9 96909.0 95144.0 124915.0 True False 45859.43519547565 48438.00426206654 56611.51921010096 84401.72944084844 87992.3316116852 67152.19984799824 60730.498338028294 97190.98914585136 114175.45854547678 121308.37938185275 0.3780401273940029 0.39929644191844404 0.46667443336210146 0.6957617426836601 0.7253607051719339 0.5535660453975527 0.5006290467937232 0.8011894119854241 0.9412000978603212 1.0 16.88831968256312 -6.257070287681435 0.1625380143752699 1.1540189440193227 1.942788764945639e-21 0.7413503127456502 0.10665757771971225 6.7246234500244295 0.3662734030616942 0.6372370988767841 1.921508615903894 5.532605604172937e-07 6.257070287681435 -1.1540189440193227 down AS(ph)SLGEIDESSELR ddPTM_A459_Selumetinib_30min_R2 1 ASSLGEIDESSELR 14 0 Q16513-3;Q16513-2;Q16513;Q16513-4;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 AS(0.681)S(0.319)LGEIDESSELR 290.17 1.3192999999999995e-66 36148000.0 47859.0 36637.0 42979.0 53602.0 46452.0 41845.0 32387.0 36722.0 32704.0 44292.0 True False 45199.18837475664 39446.940093477555 40213.777931997014 46301.315131392446 40616.28447385106 47608.76891891028 33893.05967362303 36828.854940345635 39245.713826108484 43013.174875563585 1.0508219517744775 0.917089710480496 0.9349176862283433 1.0764449558848281 0.9442754363367343 1.106841544634677 0.7879692622475578 0.8562226584503682 0.912411463223668 1.0 15.392491002535898 -7.267015189680435 24.997622274005423 0.8771694066966541 0.9983591653683731 0.34775852547933517 0.07674474577948585 507.1760219879086 2273773.333913872 0.030645011792924694 0.021310356931326848 5.4073541010634235e-08 7.267015189680435 0.121189758671719 AS(ph)SLNENVDHSALLK ddPTM_A459_Selumetinib_30min_R2 2 ASSLNENVDHSALLK 15 0 Q96SB3 Q96SB3 PPP1R9B Neurabin-2 1 AS(0.555)S(0.445)LNENVDHSALLK;AS(0.583)S(0.417)LNENVDHSALLK 155.94 0.00011089 35315000.0 193860.0 178751.0 201365.0 195843.0 191775.0 98589.0 128243.0 141454.0 118902.0 130622.0 True False 183086.0372830674 192460.6269249447 188409.39512963523 169168.8455519812 167682.5100097473 112168.73984816462 134206.55360868367 141865.60772102972 142685.7223994605 126850.60346328575 1.4433201915043141 1.5172227933519322 1.485285761247217 1.3336069433910387 1.3218897303730959 0.8842586222353251 1.0579890827837248 1.1183676218149783 1.1248328230520235 1.0 16.952770857152963 -6.459668523765043 2.3353588407822476 1.0476945680431782 1.4618213966624902 0.8373904948459066 0.08438220067038954 0.11879279592274854 1.2838538076079997 0.03041280823266163 0.03403364314141038 3.470015991515579e-07 6.459668523765043 0.41412682861931205 AS(ph)SLPGSLQR ddPTM_A459_Selumetinib_30min_R2 1 ASSLPGSLQR 10 0 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 AS(0.922)S(0.078)LPGSLQR 91.469 0.027987 6748100.0 26527.0 22140.0 25899.0 27361.0 25662.0 20871.0 15979.0 18977.0 15915.0 22018.0 True False 25052.73553599467 23838.06680867956 24232.686536699108 23634.384599642333 22438.11013880922 23745.790801925603 16722.05516178781 19032.219928188526 19098.444702254055 21382.28313036572 1.1716585821659249 1.1148513310454813 1.133306784357627 1.1053255845292933 1.0493785907709774 1.110535795319415 0.7820519006242249 0.8900929714638477 0.8931901512019403 1.0 14.384128287097854 -7.244693066278265 24.58097792596615 0.8821748430678665 1.1117287616456335 0.7873505552461412 0.056646556532649155 274.9916521227023 403645.4095610931 0.021228418607266267 0.016394207257482998 5.692551046395987e-08 7.244693066278265 0.22955391857776697 AS(ph)SMPATLLHSR ddPTM_A459_Selumetinib_30min_R2 1 ASSMPATLLHSR 12 0 Q5T7N3 Q5T7N3 KANK4 KN motif and ankyrin repeat domain-containing protein 4 1 AS(0.5)S(0.5)MPATLLHSR 148.85 0.00039143 1910900.0 23661.0 22077.0 24735.0 23744.0 21532.0 12708.0 13451.0 14171.0 10396.0 15478.0 True False 22346.01634248765 23770.234911256513 23143.577029431734 20510.02623931536 18826.95766147767 14458.411648261726 14076.498152650847 14212.235263864653 12475.490488509775 15031.109923326398 1.486651116017017 1.5814025067016568 1.5397117809321454 1.3645051060059359 1.2525327642146102 0.961899135992884 0.9364909327691022 0.945521344488942 0.8299779957798977 1.0 13.875663923850741 -6.454685367860385 1.2994339158413941 0.910953551306432 1.5445734020866315 0.9590806008903763 0.05501423373279703 0.07379472737049679 0.25693581714134117 0.022430131649517866 0.026748911506888715 3.510060742754894e-07 6.454685367860385 0.6336198507801996 AS(ph)SPAQCVTPVQTVV ddPTM_A459_Selumetinib_30min_R2 3 ASSPAQCVTPVQTVV 15 0 Q13614;Q13614-2 Q13614 MTMR2 Myotubularin-related protein 2 1 AS(0.5)S(0.5)PAQCVTPVQTVV;AS(0.578)S(0.417)PAQCVT(0.005)PVQTVV;AS(0.497)S(0.497)PAQCVT(0.006)PVQTVV 122.75 0.0015228 16660400.0 61098.0 49121.0 60466.0 63134.0 68762.0 49199.0 45178.0 52755.0 45257.0 56292.0 True False 57702.417754672664 52888.422751090744 56575.683390403065 54535.040287775286 60123.502819920446 55975.71566594496 47278.86651850867 52908.508315939616 54309.66458623388 54666.703695819204 1.0555313171202898 0.9674704925575299 1.0349203366130497 0.9975915246549979 1.0998194285586413 1.0239453246972685 0.8648567285414076 0.9678379111778409 0.9934688011998676 1.0 15.73837476578627 -7.044414290514186 24.99674322306147 0.9525092739497009 1.0294873564744937 0.3652832535478333 0.047295696199411645 486.1028506587058 273581.3864699923 0.01801140076098989 0.013952328475398033 9.02787858130244e-08 7.044414290514186 0.07697808252479288 AS(ph)SPGYIDSPTYSR ddPTM_A459_Selumetinib_30min_R1 1 ASSPGYIDSPTYSR 14 0 A0A0C4DGA7;O94929-3;O94929-2;O94929 A0A0C4DGA7 ABLIM3 Actin-binding LIM protein 3 1 AS(0.5)S(0.5)PGYIDSPTYSR 174.94 7.662399999999999e-05 11094000.0 3292.4 3806.0 3939.9 3839.0 3952.2 2896.7 3213.1 2934.3 1814.8 2871.1 True False 3369.1065141048093 3360.3917506386033 3404.88322032157 3168.590716955099 3594.724207817582 2867.5618279931646 2970.73328011835 2856.472832050317 3079.583052252299 3239.633651882273 1.0399652788355593 1.0372752328604093 1.0510087207988115 0.9780706886762035 1.1096082440460502 0.8851500311854924 0.916996672877599 0.8817271145429254 0.9505960806596194 1.0 11.661614962433898 -6.772181483306137 24.999998127729974 0.9188833312924434 1.0396744007948049 0.6384697230583782 0.04350607474818202 125.4305335526838 291911.51755395543 0.0143229097774951 0.012756270066914299 1.6897346764853907e-07 6.772181483306137 0.12079106950236151 AS(ph)SPIKQSHEPVPDTSVEK ddPTM_A459_Selumetinib_30min_R2 1 ASSPIKQSHEPVPDTSVEK 19 1 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 AS(0.495)S(0.483)PIKQS(0.023)HEPVPDTSVEK 76.156 0.0048742 23781000.0 13029.0 21177.0 20729.0 18385.0 19962.0 13963.0 13495.0 14865.0 7105.8 20050.0 True False 12304.90033921946 22801.207805212623 19395.31870802871 15880.931284106016 17454.195097455744 15886.276506506016 14122.544239835208 14908.254688966781 8527.158552640705 19471.104403843798 0.6319569801490226 1.171027966996645 0.9961077864797373 0.8156153320697596 0.8964152590137674 0.8158898528308389 0.7253078175189319 0.7656604566315066 0.4379391315346938 1.0 14.249047095798778 -6.905309310400838 1.2497386450069456 0.7038841030166515 0.9330332461134094 0.15554923708058987 0.18041378041844555 0.6968554400637753 2.2601408397957146 0.09303263698895799 0.07340841530381328 1.2436285672053482e-07 6.905309310400838 0.22914914309675793 AS(ph)SPPDRIDIFGR ddPTM_A459_Selumetinib_30min_R1 1 ASSPPDRIDIFGR 13 1 Q9NWB6-2;Q9NWB6 Q9NWB6-2 ARGLU1 Arginine and glutamate-rich protein 1 1 AS(0.564)S(0.436)PPDRIDIFGR 65.528 0.041601 317300000.0 3290.7 3592.1 5739.4 5715.4 4265.3 3337.6 3935.8 3371.3 2354.2 2458.3 True False 3367.3669074124336 3171.535262078017 4960.021004267524 4717.31268134545 3879.504368099878 3304.026774298336 3638.9194372692405 3281.8821724742656 3994.905456035025 2773.8467508697663 1.2139700602985957 1.1433707579856571 1.7881380803435742 1.7006392584111907 1.3986008300146437 1.1911352973131362 1.311867512553901 1.1831519428552424 1.4402040973541108 1.0 11.43767236869436 -6.612279240027796 5.339858983445272 1.243698793934438 1.4720580260433427 0.22344042036743272 0.20890446342674326 0.3638825846082672 16.90535147766448 0.07486972006982553 0.0748543623134181 2.441859995527898e-07 6.612279240027796 0.22835923210890474 AS(ph)SPPPQPQPPPPPAR ddPTM_A459_Selumetinib_30min_R1 1 ASSPPPQPQPPPPPAR 16 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 AS(0.619)S(0.381)PPPQPQPPPPPAR 158.31 6.9872e-05 10284000.0 664.49 743.94 620.66 795.9 847.46 656.76 744.13 814.91 385.55 493.71 True False 679.9713241275376 656.8391589516767 536.3777810413422 656.9110058933485 770.8073926312155 650.1535906903689 687.9996749974997 793.2959395992646 654.250190542139 557.0824876426444 1.220593609045064 1.17906983888717 0.9628336789244328 1.1791988089109378 1.383650374458855 1.1670688006035965 1.2350050311379301 1.4240188072617095 1.1744224689429215 1.0 9.121747154147926 -6.002813917413703 24.998530094373873 1.2518835626112566 1.117382809681385 0.11752267551248818 0.12738139835776968 191.30857391344233 1699603.6698076224 0.03498279154413589 0.05084039692329609 9.935416610114764e-07 6.002813917413703 -0.13450075292987163 AS(ph)SPPPQPQPPPPPAR ddPTM_A459_Selumetinib_30min_R2 2 ASSPPPQPQPPPPPAR 16 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 AS(0.914)S(0.086)PPPQPQPPPPPAR;AS(0.5)S(0.5)PPPQPQPPPPPAR 195.94 1.2373e-06 8137400.0 17703.4 17951.4 18216.9 19561.6 21716.1 15508.0 15890.1 15516.8 14511.3 17972.3 True False 16719.515900325245 19328.214657151344 17044.84448706104 16897.276334357804 18987.929373602787 17644.086232392423 16629.02113563581 15561.95131905548 17413.965479599065 17453.393001356697 0.9579521815056588 1.107418749789735 0.9765920291679733 0.9681370455042373 1.0879219514581953 1.0109258544181583 0.9527672432714482 0.8916289983183104 0.9977409824121551 1.0 14.0912199082704 -7.2328340236443776 5.1877569036372515 0.951223375004954 1.021690353232559 0.20894724914250673 0.05370504356736162 0.25556124884251097 19.786758564248927 0.020946263121124027 0.015543104188392843 5.850136188209954e-08 7.2328340236443776 0.07046697822760495 AS(ph)SPSLIER ddPTM_A459_Selumetinib_30min_R2 2 ASSPSLIER 9 0 A1L170;A1L170-2 A1L170 C1orf226 Uncharacterized protein C1orf226 1 AS(0.619)S(0.381)PSLIER;AS(0.617)S(0.379)PS(0.004)LIER 97.597 0.02045 9240500.0 65744.0 55642.0 59217.0 71182.0 58868.0 64640.0 92668.0 110508.0 61330.0 63134.0 True False 62090.21167408425 59909.562482770954 55407.04269059467 61486.88880420086 51472.475553402735 73543.57325650283 96977.24561815847 110829.55998441587 73597.71370337685 61311.15737816828 1.0127065664591968 0.9771396438212336 0.9037024427518644 1.0028662226183183 0.839528688651555 1.1995137003022924 1.5817226385077212 1.807657280074118 1.2003967442569201 1.0 15.903862018382783 -7.006401340583019 4.247343209604586 1.4606679504732856 0.9516129797540848 0.4978987085326946 0.2094553414662175 0.15129037672715037 6.563350172998681 0.07732231713140729 0.06336908027181302 9.853684652121648e-08 7.006401340583019 -0.5090549707192008 AS(ph)SPSPLTIGTPESQRK ddPTM_A459_Selumetinib_30min_R2 2 ASSPSPLTIGTPESQRK 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 AS(0.564)S(0.218)PS(0.218)PLT(0.001)IGTPESQRK;AS(0.473)S(0.411)PS(0.116)PLTIGTPESQRK 77.899 0.0099509 23708100.0 121841.0 108751.0 118589.0 137240.0 129076.0 95180.0 106545.0 106332.0 69181.0 118539.0 True False 115069.56498816787 117091.85201042087 110959.11284994047 118547.67524779474 112860.31892591926 108290.18104198537 111499.55361491238 106641.40851578987 83019.13307864525 115116.47106869046 0.9995925337174851 1.0171598462269722 0.9638856353034895 1.0298063704285798 0.9804011352864965 0.9407010138224979 0.9685803654316345 0.9263783672812252 0.7211751047259553 1.0 16.812734746039276 -8.009134022125494 6.4601702461966415 0.8481389663780083 0.9835962909922802 0.35484163387561196 0.06723997317047532 0.13579501384660972 26.317683745084175 0.038952957711120756 0.01636529201229664 9.79187764031278e-09 8.009134022125494 0.13545732461427185 AS(ph)SVTTFTGEPNTCPR ddPTM_A459_Selumetinib_30min_R2 1 ASSVTTFTGEPNTCPR 16 0 H0YFA4;P52943;P52943-2 H0YFA4 CRIP2 Cysteine-rich protein 2 1 AS(0.636)S(0.361)VT(0.004)TFTGEPNTCPR 220.25 8.4654e-11 12699000.0 63708.0 68915.0 58442.0 60686.0 49394.0 38581.0 40958.0 43624.0 37552.0 44586.0 True False 60167.364403330525 74200.55890334927 54681.90534683846 52420.46211081084 43188.684132037335 43895.182546552205 42862.62815673733 43750.93861765801 45063.44929054631 43298.68633165985 1.389588680415377 1.713690765003512 1.26289987017124 1.2106709591436537 0.9974594564190721 1.0137763120646042 0.9899290668640062 1.010444942429292 1.0407578868644816 1.0 15.402035634257809 -5.702588661515922 1.6324517295844914 1.009923869463142 1.5534075796112443 0.8393569705891 0.09062626914517476 0.12814628156414015 0.6871512903998265 0.026552091833422522 0.06216552348038442 1.983404702073687e-06 5.702588661515922 0.5434837101481023 AS(ph)TPDWVSEGPQPGLR ddPTM_A459_Selumetinib_30min_R1 1 ASTPDWVSEGPQPGLR 16 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 AS(0.5)T(0.5)PDWVSEGPQPGLR 74.793 0.021073 9050200.0 7882.9 5236.7 5863.0 7002.3 6608.7 5561.3 4754.7 4914.5 2947.2 4551.8 True False 8066.556232546713 4623.58472952422 5066.836803153723 5779.479754450296 6010.944251860753 5505.358371256387 4396.049150969069 4784.151495454205 5001.183145028638 5136.067868286626 1.570570412894035 0.9002187759381441 0.9865206093633653 1.1252732445644862 1.1703397240866256 1.0719014063754875 0.8559172627202014 0.9314813624240874 0.9737377451550333 1.0 12.326448551100814 -7.080939980823066 5.304575509673605 0.935768408967187 1.125921913967332 0.2522476598627579 0.16798344082427547 0.3529210488338991 17.00317161977633 0.06406625785142266 0.049785240886445696 8.299654602031874e-08 7.080939980823066 0.19015350500014494 AS(ph)TPDWVSEGPQPGLR ddPTM_A459_Selumetinib_30min_R2 3 ASTPDWVSEGPQPGLR 16 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 AS(0.5)T(0.5)PDWVSEGPQPGLR;AS(0.801)T(0.199)PDWVSEGPQPGLR;AS(0.5)T(0.5)PDWVSEGPQPGLR 258.96 5.3048999999999995e-39 240736000.0 103920.0 85815.0 90256.0 103018.0 73591.0 58304.0 88814.0 68781.0 59040.0 68803.0 True False 98144.54242472061 92396.73456128433 84449.02722330265 88986.77068403791 64345.84066811281 66334.84676898425 92944.02698160225 68981.14132269255 70849.64971543064 66816.47861833753 1.4688673281531663 1.3828435211179537 1.263895209229508 1.3318087472454112 0.9630235235182439 0.9927917205558766 1.391034500822887 1.03239713838737 1.0603619223953868 1.0 16.027916330888445 -6.161288316335371 6.25018368017503 1.087255513542446 1.36016375571674 0.5703916902902748 0.12246093369002406 0.20177961057662394 10.614608618924482 0.03799184567370636 0.04931343399643393 6.897817244128885e-07 6.161288316335371 0.2729082421742941 AS(ph)TPQPAPAGVPALASQHPPEEEVHYHLPVAR ddPTM_A459_Selumetinib_30min_R2 2 ASTPQPAPAGVPALASQHPPEEEVHYHLPVAR 32 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 AS(0.5)T(0.5)PQPAPAGVPALASQHPPEEEVHYHLPVAR;AS(0.5)T(0.5)PQPAPAGVPALASQHPPEEEVHYHLPVAR 88.454 8.487099999999999e-08 16459400.0 17939.7 15530.5 24233.4 28668.5 29733.1 15946.3 12979.599999999999 15936.3 14428.2 25969.9 True False 16942.683292309102 16721.639411571727 22674.24942733096 24763.800844079055 25997.762160713457 18142.75807890115 13583.177118589465 15982.671994603514 17314.24315759108 25220.081509096417 0.6717933598350263 0.6630287616453793 0.8990553586891771 0.9819080416194218 1.0308357707462819 0.7193774561100207 0.5385857739472517 0.6337280071374416 0.6865260586626635 1.0 14.622285317887238 -6.980397326564739 24.8636709076963 0.6763007312523692 0.851703506293727 0.13664959830095136 0.15649703747759353 366.0732394238859 464318.9988000002 0.05775557559625624 0.05092927021268637 1.0461709910343146e-07 6.980397326564739 0.17540277504135782 AS(ph)TPVLK ddPTM_A459_Selumetinib_30min_R2 1 ASTPVLK 7 0 A0A669KBK8;Q04724;F6T2C8;A0A669KAE5 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 AS(0.664)T(0.336)PVLK 107.01 0.016878999999999998 20918000.0 345810.0 315410.0 326670.0 352560.0 387550.0 283110.0 297270.0 274810.0 259470.0 301930.0 True False 326591.26458711183 339600.93279700243 305652.4078514031 304540.71980007656 338862.5042590411 322105.83268330025 311093.64402933 275609.6516027552 311371.2501975403 293212.4963916489 1.1138381501683283 1.1582075695143352 1.0424262663182609 1.0386348588407242 1.155689162055415 1.0985406033072276 1.06098357968276 0.9399655710260681 1.0619303543653762 1.0 18.16158706528261 -7.548838562922366 6.612414755788412 1.00002111139792 1.0992126335048633 0.487986712404594 0.04607965335495581 0.1516528078189636 23.146675424174916 0.02206307940112244 0.012859451434941726 2.825930241860334e-08 7.548838562922366 0.09919152210694326 AS(ph)VETLTEMLQS(ph)Y(ph)ISEIGRSAK ddPTM_A459_Selumetinib_30min_R1 1 ASVETLTEMLQSYISEIGRSAK 22 1 C9J7M8;A0A0A0MRR3;Q7Z7C8;Q7Z7C8-2;Q7Z7C8-4 C9J7M8 TAF8 Transcription initiation factor TFIID subunit 8 3 AS(0.364)VET(0.32)LT(0.318)EMLQS(0.992)Y(0.839)IS(0.161)EIGRS(0.006)AK 51.566 0.030603 3456400.0 890.35 934.3 1056.1 1141.2 1021.4 784.3 1388.6 1566.1 656.44 974.99 True False 911.093422680481 824.9117216557138 912.6874207420515 941.9108429771194 929.0145503428165 776.4106540874235 1283.8567840317262 1524.5619405902594 1113.9307355193405 1100.139463706836 0.8281617492482464 0.7498246802966567 0.8296106546953791 0.8561740343387215 0.8444516181726386 0.7057383901777026 1.1669945733115223 1.3857897029285398 1.012535930459249 1.0 10.103470709179746 -7.271894183386123 24.70338414520043 1.173479235795656 0.8055429268374313 0.694734236369736 0.10924711422870055 310.1976536301748 732954.7420152682 0.04365110938207857 0.029792969076221254 5.3469462281155556e-08 7.271894183386123 -0.3679363089582247 AS(ph)VGQDSPEPR ddPTM_A459_Selumetinib_30min_R2 1 ASVGQDSPEPR 11 0 Q6UX71-2;Q6UX71 Q6UX71-2 PLXDC2 Plexin domain-containing protein 2 1 AS(0.908)VGQDS(0.092)PEPR 79.23 0.046077 3167700.0 38121.0 40710.0 50227.0 48271.0 46120.0 30601.0 33366.0 31268.0 24290.0 41306.0 True False 36002.387430454 43832.326096718396 46995.44950302276 41696.40652788039 40325.99328196873 34816.00998177975 34917.58511347471 31358.984703303926 29148.678719305757 40113.38845412331 0.8975154884167673 1.092710633180449 1.1715651884350358 1.0394635839744013 1.005300096452549 0.8679398904831478 0.8704720907187656 0.7817585577236492 0.726657104837762 1.0 15.291796218040028 -6.742348263183783 1.9169784919475643 0.8258559114404993 1.0624362794645223 0.5227885385981734 0.09185429849137178 0.24855296301530816 1.8836497311891156 0.03731408841587394 0.0346703756913326 1.809888151065749e-07 6.742348263183783 0.23658036802402305 AS(ph)VSGPNSPS(ph)ETRR ddPTM_A459_Selumetinib_30min_R1 1 ASVSGPNSPSETRR 14 1 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 2 AS(0.965)VS(0.033)GPNS(0.214)PS(0.521)ET(0.266)RR 120.99 0.006674500000000001 13400000.0 4448.5 5535.3 6628.1 6705.6 5710.5 5043.0 5811.0 5447.6 2685.4 3704.7 True False 4552.141394725804 4887.224502708843 5728.040425547196 5534.592839701512 5193.98628327066 4992.271998677643 5372.671591537063 5303.111951701362 4556.927666144107 4180.234331833879 1.088967993985344 1.1691269232183943 1.3702677818624323 1.32399104939016 1.242510795080726 1.1942564943452634 1.2852560801729167 1.2686159508610308 1.0901129708068236 1.0 12.029368102542142 -8.432407060910933 3.342769079446136 1.0022056608216672 1.2470455161529015 0.5349736829646663 0.07576117287933232 0.1817031669969035 3.8456796998070764 0.07795515975063363 0.020731945975101224 3.6948170504286365e-09 8.432407060910933 0.2448398553312343 AS(ph)VSPMDEPVPDSESPIEK ddPTM_A459_Selumetinib_30min_R1 1 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AS(0.622)VS(0.378)PMDEPVPDSESPIEK 154.65 4.013e-06 58626000.0 2223.4 3021.5 2927.5 3089.6 3046.6 2727.3 2705.5 2563.0 1220.5 2246.6 True False 2275.2008940167148 2667.741375342758 2529.961579606435 2550.0593589748555 2771.0355679209165 2699.865838190272 2501.4219567894543 2495.020914202694 2071.099358206926 2534.9729937371435 0.8975247072208592 1.052374672997949 0.9980230897358316 1.0059512922918643 1.0931223231044216 1.065047179934662 0.9867647359437044 0.9842396429338085 0.8170104231184099 1.0 11.307754662261893 -8.045699824275129 7.462750742128331 0.9051684494877944 1.0173747592561653 0.292431073854863 0.06466436121348837 0.3097571623857307 43.62556379331463 0.04197732650332708 0.01606373197685537 9.00119511310792e-09 8.045699824275129 0.11220630976837087 AS(ph)VSPMDEPVPDSESPIEK ddPTM_A459_Selumetinib_30min_R2 3 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AS(0.552)VS(0.448)PMDEPVPDSESPIEK;AS(0.591)VS(0.409)PMDEPVPDSESPIEK;AS(0.551)VS(0.448)PMDEPVPDSESPIEK 80.314 0.0042307 29029500.0 262711.0 241899.0 282625.0 301363.0 299697.0 251371.0 248734.0 235186.0 220326.7 295767.0 True False 248110.57433545808 260451.87547212248 264441.21519883286 260316.83951982833 262046.3835348261 285995.07353125594 260300.6238570708 235870.35232286146 264398.19644235796 287227.438215046 0.8638122314404333 0.9067792307402165 0.9206683624732495 0.9063090947631895 0.912330608674764 0.9957094465227677 0.9062526389355072 0.8211971453307545 0.9205185900255257 1.0 18.13183404771332 -4.750725239199402 2.7701059390571356 0.9175024300908747 0.8512013071938495 0.1158767762885643 0.04743164573195691 1.2702743589225212 12.381114530104853 0.012512792448208424 0.20175667105170658 1.7753122949688253e-05 4.750725239199402 -0.06630112289702528 AS(ph)WESLDEEWR ddPTM_A459_Selumetinib_30min_R1 3 ASWESLDEEWR 11 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 AS(0.989)WES(0.011)LDEEWR;AS(0.954)WES(0.046)LDEEWR;AS(0.559)WES(0.441)LDEEWR 145.31 0.00070404 8227000.0 1519.03 1992.33 1724.4099999999999 1734.63 1917.5900000000001 1401.97 1629.4599999999998 1753.0300000000002 845.5600000000001 1522.72 True False 1554.4204434821497 1759.0670773909117 1490.2445935061087 1431.709433537854 1744.144323078011 1387.8674546869124 1506.548520314227 1706.5339497560458 1434.8535627410472 1718.1759445488399 0.9046922397055854 1.0237991533822859 0.8673410882244765 0.8332728892405682 1.015113922768829 0.8077563063841753 0.8768301785937399 0.9932242126717407 0.8351028119636562 1.0 10.746662063473199 -10.756645005503081 3.7704174787147022 1.000111414755656 0.9084922400137679 0.12346740617537355 0.07466284579621238 15761705.45972098 8993342.748293636 14291.818563714682 0.01754940804570063 1.751277606861606e-11 10.756645005503081 -0.09161917474188808 AS(ph)WESLDEEWR ddPTM_A459_Selumetinib_30min_R2 2 ASWESLDEEWR 11 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 AS(1)WESLDEEWR;AS(0.995)WES(0.005)LDEEWR 117.95 0.0044263 920220.0 5217.5 4280.6 5670.3 8411.0 10683.0 6074.799999999999 5197.5 7371.9 7723.4 5302.8 True False 4927.532237307355 4608.908255701617 5305.4790713558405 7265.407290215704 9340.906032768256 6911.548558456118 5439.194048650866 7393.351008516255 9268.29580982651 5149.694385670966 0.9568591586751677 0.8949867527140859 1.0302512487184377 1.4108424201699645 1.8138758017872565 1.3421279091216587 1.0562168628463533 1.4356873349782209 1.7997758926462821 1.0 12.330271101159932 -5.710149096632012 4.1489797137870426 1.427698153843736 0.9367056662848805 0.40691167519860594 0.24878221697713726 0.20974469656379532 7.433322510711105 0.07142821655567619 0.12473733655820192 1.949175318019038e-06 5.710149096632012 -0.4909924875588556 ASAAFSS(ph)VGSVITK ddPTM_A459_Selumetinib_30min_R2 2 ASAAFSSVGSVITK 14 0 H0YC42;P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6 H0YC42 TPD52 Tumor protein D52 1 ASAAFS(0.01)S(0.729)VGS(0.26)VITK;ASAAFS(0.031)S(0.947)VGS(0.022)VITK 154.6 0.00034115 7583300.0 27286.8 44782.0 48380.0 50871.0 43140.0 28176.0 23065.2 33946.0 26332.0 35231.8 True False 25770.30889371507 48216.63540317474 45267.28347216122 43942.28204263025 37720.367523506735 32056.988243737982 24137.777502826753 34044.77723993718 31599.135777552852 34214.56639079022 0.753197003854237 1.4092429187164435 1.323041272980918 1.284315035319533 1.1024651633071754 0.9369397781515358 0.7054824903268128 0.9950375185552917 0.9235579786876568 1.0 15.062323043424511 -6.656556122795405 3.0928709372166225 0.8961937677060763 1.2155398365790189 0.3489913568582469 0.18075865895337195 0.26182357549292506 5.010348852508668 0.06366912473803925 0.0627873054195173 2.205179148163985e-07 6.656556122795405 0.3193460688729426 ASAEGPLLGPEAAPS(ph)GEGAGSKGEAVLRPGLDAEPELSPEEQR ddPTM_A459_Selumetinib_30min_R1 1 ASAEGPLLGPEAAPSGEGAGSKGEAVLRPGLDAEPELSPEEQR 43 2 C9JQV0;Q9BRJ6 C9JQV0 C7orf50 Uncharacterized protein C7orf50 1 ASAEGPLLGPEAAPS(0.497)GEGAGS(0.123)KGEAVLRPGLDAEPELS(0.38)PEEQR 46.128 0.0017710999999999996 9571600.0 291.22 652.8 1176.2 1134.2 795.86 754.56 418.17 506.29 282.09 305.95 True False 298.0048593845229 576.3698725215136 1016.4785004041297 936.1332615708448 723.8746035204955 746.9698114856633 386.62710022940166 492.86154453830704 478.6861269615667 345.2216627053677 0.8632275768825597 1.6695646153973287 2.9444227005871637 2.7116874828616866 2.0968400356100836 2.1637396843290535 1.1199387002529206 1.4276669102278898 1.3866051255598792 1.0 8.431379186438264 -7.2568153364229175 24.570944845180012 1.2691915789816384 2.125952813032839 0.36247613621143016 0.5432917886465913 378.06684494713113 2008954.942086363 0.23205680934434325 0.17355489240777222 5.535854457035451e-08 7.2568153364229175 0.8567612340512007 ASAGRLT(ph)PESQSK ddPTM_A459_Selumetinib_30min_R1 2 ASAGRLTPESQSK 13 1 J3KQV8;O43426;A0A0D9SGJ6;C9JFZ1;O43426-2;J3KPK1;O43426-4;H7BZ56;H7BZC2 J3KQV8 SYNJ1 Synaptojanin-1 1 AS(0.001)AGRLT(0.997)PES(0.001)QSK;ASAGRLT(0.984)PES(0.014)QS(0.002)K 138.01 0.010472 8396800.0 3504.4 3757.9 4312.799999999999 5282.4 4291.5 3160.3999999999996 3683.3 3438.2 2140.24 2875.8999999999996 True False 3586.045701624621 3317.923320999685 3727.145448514649 4359.928002928787 3903.3345827258654 3128.609245413606 3405.4657155581585 3347.0077671524396 3631.8309630551344 3245.049778638233 1.1050818773971118 1.0224568334332402 1.1485634128172681 1.3435627495238012 1.202858152876742 0.9641174893552817 1.0494340450417508 1.0314195452980055 1.1191911405991473 1.0 11.664024893809058 -6.751970520870058 24.998048600298365 1.0358337616459494 1.1656751249175243 0.37851036648571 0.0843105174862998 249.9494975459608 659872.4398032436 0.03132599734193287 0.03092716530484894 1.7702291142143836e-07 6.751970520870058 0.12984136327157492 ASAGTPSLSAGVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ASAGTPSLSAGVSPK 15 0 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 ASAGTPSLSAGVS(1)PK;ASAGTPSLSAGVS(1)PK 140.68 0.00038855 52443000.0 8701.400000000001 10567.4 12039.2 11239.0 8110.1 9464.1 8273.0 8659.599999999999 5832.0 9086.8 True False 8904.125690022956 9330.163895349024 10404.342766591903 9276.319632158995 7376.542886954448 9368.899746715262 7648.960949369489 8429.919277654948 9896.478047572955 10253.179292927385 0.8684258253598469 0.9099776399877202 1.0147430830326736 0.9047261700141901 0.7194395685680408 0.9137555756172042 0.7460086994329379 0.8221761306241746 0.9652106692798709 1.0 13.323783707713293 -4.450855770970318 14.85193321189889 0.8790401607320595 0.7438685453356316 0.0 0.09470861514157902 15212901.757851887 72496840.4587188 0.02422936482008521 63305595.571929865 3.541149229870394e-05 4.450855770970318 -0.13517161539642786 ASALLFSS(ph)DEEDQWNIPASQTHLASDSR ddPTM_A459_Selumetinib_30min_R1 3 ASALLFSSDEEDQWNIPASQTHLASDSR 28 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;Q9Y4E1-5;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 AS(0.032)ALLFS(0.088)S(0.879)DEEDQWNIPAS(0.001)QTHLASDSR;ASALLFS(0.162)S(0.838)DEEDQWNIPASQTHLASDSR;AS(0.006)ALLFS(0.069)S(0.924)DEEDQWNIPAS(0.001)QTHLASDSR 182.11 7.0683e-27 14594600.0 2550.9 2625.6099999999997 2568.95 2683.0600000000004 3441.33 2498.05 2741.83 2178.51 624.77 1648.7 True False 2610.331006812648 2318.202360587027 2220.1007002322644 2214.5139382739117 3130.0623091161597 2472.9218850479247 2535.0115556400037 2120.728838002228 1060.189058604623 1860.3267046979572 1.4031573057682154 1.2461264759210189 1.193392910302129 1.1903898023296184 1.682533665302814 1.329294407698904 1.3626700886668122 1.1399765603787049 0.5698940169634104 1.0 10.861340289789991 -8.044920082631773 4.44204138662068 0.7900378050798953 1.337571561190349 0.6448108744224443 0.1641710904494835 0.13274048184178502 5.667413482405001 0.11592848636059917 0.043299688202966896 9.017370568734169e-09 8.044920082631773 0.5475337561104536 ASALLFSS(ph)DEEDQWNIPASQTHLASDSR ddPTM_A459_Selumetinib_30min_R2 3 ASALLFSSDEEDQWNIPASQTHLASDSR 28 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;Q9Y4E1-5;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 AS(0.001)ALLFS(0.189)S(0.811)DEEDQWNIPASQTHLASDSR;AS(0.001)ALLFS(0.18)S(0.819)DEEDQWNIPASQTHLASDSR;ASALLFS(0.171)S(0.829)DEEDQWNIPASQTHLASDSR 131.84 1.8892e-12 8429900.0 22554.3 17824.5 28202.6 31712.9 34513.9 27014.9 21188.5 24509.3 23901.8 24637.7 True False 21300.822298016523 19191.581835199155 26388.07542066913 27393.5483121961 30177.95532381915 30735.95725815436 22173.807234216245 24580.618005266948 28682.827872091486 23926.345584567698 0.8902664313164224 0.80211086843022 1.1028878324690432 1.1449115041565194 1.261285607413599 1.284607260624824 0.9267527778466167 1.0273452716958686 1.1987968564071765 1.0 14.546312441715077 -5.292499490267218 7.343865417248656 1.1249304010518202 0.8461006855339948 0.4989340067204985 0.10894237564708936 0.167573211024955 33.478492845908384 0.03047676321381859 0.06566771461264413 5.099181960670888e-06 5.292499490267218 -0.2788297155178254 ASAPS(ph)PEDSVFADTGK ddPTM_A459_Selumetinib_30min_R1 2 ASAPSPEDSVFADTGK 16 0 J3KQ40;O95759-2;O95759 J3KQ40 TBC1D8 TBC1 domain family member 8 1 ASAPS(1)PEDSVFADTGK;AS(0.002)APS(0.886)PEDS(0.112)VFADTGK 243.99 7.0626e-22 16910700.0 7213.1 8001.5 8565.1 7909.6 8110.3 6617.9 7139.4 7827.1 3961.2 5659.0 True False 7381.151195750636 7064.680660203572 7402.006464726581 6528.336841580637 7376.724796989759 6551.329934572435 6600.869310036086 7619.499881996054 6721.867085398838 6385.387773327914 1.1559440801045906 1.1063824016629185 1.159210172895863 1.0223869048094194 1.155250872594255 1.0259877970039142 1.0337460377282408 1.1932712863301878 1.0526952041153106 1.0 12.640558519573636 ASAPS(ph)PEDSVFADTGK ddPTM_A459_Selumetinib_30min_R2 2 ASAPSPEDSVFADTGK 16 0 J3KQ40;O95759-2;O95759 J3KQ40 TBC1D8 TBC1 domain family member 8 1 ASAPS(1)PEDSVFADTGK;ASAPS(1)PEDSVFADTGK 206.13 8.213100000000001e-08 10447200.0 66491.0 49109.0 59428.0 58505.0 56662.0 41302.0 43125.0 55461.0 38436.0 47464.0 True False 62795.696404562135 52875.50238967681 55604.46718031412 50536.51807324567 49543.61299529296 46990.97559777353 45130.39795056637 55622.3823279372 46124.27399157001 46093.59099371782 1.3623520114351835 1.1471335005528926 1.2063383646523125 1.0963892589781816 1.074848193147836 1.0194687500953878 0.9791035364703364 1.2067270336025258 1.0006656673344536 1.0 15.492278547029125 -1.5228787452803463 0.5021167955602261 1.0456915480819942 10.701389258815652 0.6571730290128565 0.06790387092026413 69.18484283358133 0.7308675255142937 0.03703317311359501 705.3788527344569 0.0299999999999994 1.5228787452803463 9.655697710733659 ASAPS(ph)PNAQVACDHCLK ddPTM_A459_Selumetinib_30min_R1 3 ASAPSPNAQVACDHCLK 17 0 A0A3B3IUA7;Q14258 A0A3B3IUA7 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 ASAPS(1)PNAQVACDHCLK;ASAPS(1)PNAQVACDHCLK;AS(0.01)APS(0.99)PNAQVACDHCLK 240.82 1.2482999999999999e-22 89132700.0 12886.300000000001 11884.999999999998 11195.9 9383.7 11184.3 9149.0 11456.1 11106.699999999999 7968.7 9914.5 True False 13186.525717625074 10493.498674813398 9675.55827467658 7745.0129488647 10172.68203974854 9056.96936662735 10591.957153640973 10812.114236353893 13522.301889179467 11187.122650408126 1.1787236208717178 0.9379980002660091 0.8648835430729453 0.6923150117230679 0.9093206857240832 0.8095888147160822 0.9467990550058517 0.9664785641694424 1.2087381457899855 1.0 13.449551399618743 -7.9938336654733835 3.1308954829273756 1.1040572534995583 0.8937505131074508 0.2723457777089545 0.12571081280986876 0.3251983970453063 6.362086272289364 0.09373426630757772 0.034892906618452985 1.0142997875646131e-08 7.9938336654733835 -0.2103067403921075 ASAPS(ph)PNAQVACDHCLK ddPTM_A459_Selumetinib_30min_R2 7 ASAPSPNAQVACDHCLK 17 0 A0A3B3IUA7;Q14258 A0A3B3IUA7 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 AS(0.001)APS(0.999)PNAQVACDHCLK;ASAPS(1)PNAQVACDHCLK;ASAPS(1)PNAQVACDHCLK;AS(0.001)APS(0.999)PNAQVACDHCLK;ASAPS(1)PNAQVACDHCLK;AS(0.011)APS(0.989)PNAQVACDHCLK;AS(0.021)APS(0.979)PNAQVACDHCLK 248.23 2.0499999999999998e-30 469907300.0 313833.9 264747.5 289616.4 302070.8 312161.4 285546.7 291153.1 294774.0 239788.8 265280.1 True False 296392.26821464166 285052.7819526149 270982.79613449425 260928.2359388052 272944.894173676 324878.1659901395 304692.29605892266 295631.74353753764 287753.2602588663 257620.7742325243 1.1504983210209703 1.1064821259147792 1.05186702020354 1.012838489893271 1.059483246204828 1.2610713051305007 1.1827163277753072 1.1475462117457393 1.1169645037986917 1.0 17.97488940979074 ASAS(ph)PDRIPSLPQETVDQEPK ddPTM_A459_Selumetinib_30min_R1 1 ASASPDRIPSLPQETVDQEPK 21 1 A0A494C1R1;A0A2R8Y5U1;Q76L82;Q8IXJ9 A0A494C1R1 ASXH1;ASXL1 Putative Polycomb group protein ASXL1 1 AS(0.063)AS(0.936)PDRIPSLPQET(0.001)VDQEPK 95.834 0.00022281 11008000.0 2425.4 2165.8 2548.6 2480.2 2022.5 2226.0 2032.6 1979.6 1543.3 1795.6 True False 2481.907100993138 1912.2271291468962 2202.514118457715 2047.0796291200925 1839.5652321013756 2203.60846104629 1879.2793455443525 1927.0945773529663 2618.8673818277334 2026.082750625129 1.2249781506838102 0.9438050487113108 1.0870800404268532 1.0103632877228164 0.9079418061941423 1.0876201677184147 0.9275432333474625 0.9511430748612707 1.292576712880906 1.0 10.984477383519051 -10.881969790801865 11.58937122341059 0.9999999986669864 1.035725036077154 0.004613385869224218 0.1230440706520521 4.0274629905353645e-09 1.454473547096314e-10 0.11312161533330718 0.027436020657911845 1.3122911778337136e-11 10.881969790801865 0.035725037410167526 ASAS(ph)PGENDSGTGGEEPQR ddPTM_A459_Selumetinib_30min_R1 1 ASASPGENDSGTGGEEPQR 19 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ASAS(1)PGENDSGTGGEEPQR 274.82 3.224e-59 3428500.0 1234.4 1151.7 991.13 1095.8 1305.7 821.1 1400.7 1282.3 734.96 976.43 True False 1263.1591182757188 1016.8584285891961 856.5399898873876 904.4391007135703 1187.5996655400588 812.8404794991493 1295.0440712899604 1248.2892385025805 1247.173440645443 1101.7643017336234 1.1464876074566412 0.9229364456528243 0.7774257965516074 0.8209007128751926 1.077907192737479 0.7377625851737498 1.1754275113581114 1.1329911819963676 1.1319784446482961 1.0 10.105599908671362 -7.283904975865591 24.95825073728424 1.1211818986599928 0.9113377663351956 0.36866038100748066 0.12541876458034398 838.1879174622379 931184.3985499566 0.05227974850100706 0.03527660665078494 5.201097847063808e-08 7.283904975865591 -0.20984413232479726 ASAS(ph)PGENDSGTGGEEPQR ddPTM_A459_Selumetinib_30min_R2 1 ASASPGENDSGTGGEEPQR 19 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 AS(0.001)AS(0.999)PGENDSGTGGEEPQR 225.69 1.8261e-20 7090600.0 9222.9 5270.9 7431.0 8366.9 7666.8 5753.1 6341.2 8061.0 6634.3 5960.5 True False 8710.328140193957 5675.16108138524 6952.897550261057 7227.313786292444 6703.628041938368 6545.537303557957 6636.078364849424 8084.456175429608 7961.345377829979 5788.404877761145 1.5047890263617774 0.9804360961668415 1.201176783084724 1.2485847031985509 1.1581131906811633 1.1308015665430884 1.146443364793816 1.3966639076146545 1.3753953888777195 1.0 12.49895012130528 -7.734278381107519 24.99244873323656 1.2895224506383358 1.1857748604058032 0.015992972643167347 0.16003977306804484 541.9865982696425 498714.6178094325 0.07116583811640335 0.04107360261464155 1.8438331502837528e-08 7.734278381107519 -0.10374759023253266 ASAS(ph)PSTSSTSSRPK ddPTM_A459_Selumetinib_30min_R1 2 ASASPSTSSTSSRPK 15 1 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;F5H858 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 ASAS(0.999)PS(0.001)TSSTSSRPK;AS(0.174)AS(0.775)PS(0.046)T(0.005)SSTSSRPK 192.54 0.00014261 10144300.0 2131.45 2290.2200000000003 2760.93 2731.34 2288.82 1900.15 2132.52 2410.91 1282.94 1962.84 True False 2181.1086379202684 2022.079977705607 2386.0108707029176 2254.3627426017556 2081.796635123991 1881.03621619816 1971.662299498299 2346.9648350606362 2177.0554777697625 2214.7896336806807 0.9847926885478333 0.9129896343000232 1.0773081264326176 1.017867660349895 0.9399523112560025 0.8493069443675029 0.8902255408436526 1.059678445017958 0.982962645599795 1.0 11.112953959127017 -7.773464024098314 24.99989216274144 1.0159903871389495 0.954413585662746 0.16176170847441307 0.06356111040165961 485.92467031447904 1010248.0136539328 0.03812679440363264 0.018531413328671295 1.6847519817622983e-08 7.773464024098314 -0.06157680147620348 ASAS(ph)PSTSSTSSRPK ddPTM_A459_Selumetinib_30min_R2 2 ASASPSTSSTSSRPK 15 1 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;F5H858 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 AS(0.101)AS(0.897)PS(0.002)TSSTSSRPK;AS(0.001)AS(0.996)PS(0.003)TSSTSSRPK 104.26 0.0028167 18091200.0 46542.0 40639.0 45883.0 49183.0 40713.0 34976.0 36938.0 36701.0 31101.0 37839.0 True False 43955.38196238788 43755.880625019396 42930.937733633145 42484.19055459267 35598.26896116201 39793.62651948397 38655.69019125845 36807.793833822376 37322.06903454626 36746.489752471076 1.1961790706670705 1.1907499442739824 1.1683003743438156 1.1561428272678957 0.9687529122089313 1.082923206748149 1.0519559950255926 1.0016682976187454 1.0156635174122033 1.0 15.1653188211018 -6.142875062099202 5.18552475097744 1.0253360818408592 1.1819287111034753 0.8671630644334749 0.030296745447941847 0.0820058897270134 3.1609026329406893 0.009269442664044919 0.012108070741537674 7.196559789657234e-07 6.142875062099202 0.15659262926261608 ASAVSELS(ph)PR ddPTM_A459_Selumetinib_30min_R1 8 ASAVSELSPR 10 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 ASAVSELS(1)PR;ASAVSELS(1)PR;ASAVSELS(1)PR;ASAVS(0.004)ELS(0.995)PR;ASAVSELS(1)PR;ASAVS(0.003)ELS(0.997)PR;ASAVSELS(1)PR;ASAVSELS(1)PR 155.47 0.00052481 5114168900.0 26591.8 29439.600000000002 31284.7 30765.9 29934.3 27094.199999999997 30495.0 28624.499999999996 15659.599999999999 21955.5 True False 27211.33720136444 25992.797945901257 27036.409574556244 25393.21311246911 27226.747850329895 26821.656947565305 28194.737598334654 27865.285274520094 26573.197468068152 24773.70228968033 1.0983960686691359 1.0492092639996224 1.0913350478833543 1.0250067921033685 1.099018125428568 1.0826664756820812 1.1380914030794413 1.1247929335990927 1.0726373134441605 1.0 14.596521866859208 ASAVSELS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 ASAVSELSPR 10 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 ASAVSELS(1)PR;ASAVSELS(1)PR;ASAVSELS(1)PR;ASAVSELS(1)PR;ASAVS(0.003)ELS(0.997)PR 139.76 0.0014922000000000002 4438966000.0 422892.0 362958.0 457836.0 522191.0 537299.0 383438.0 354261.0 382847.0 375505.0 457127.0 True False 399389.3556108061 390795.71150608454 428379.3302141467 451067.68497028115 469798.69610599504 436253.10399639397 370734.8384548539 383961.02138626715 450616.492486329 443928.55575141683 0.8996703420774063 0.8803121728553892 0.9649735856461167 1.0160817075774282 1.058275459011167 0.9827101643821246 0.835122754893135 0.8649162492742881 1.0150653447458269 1.0 18.75996798759615 -5.265387783065819 23.742539496441 0.9631622229369072 0.8899912510495649 0.18101182164894414 0.06520514200682577 312.6497752892345 1880053.5795984338 0.019212074740016294 0.042610562451650826 5.427654778624107e-06 5.265387783065819 -0.07317097188734234 ASCGPPS(ph)LPDPTFLPDAER ddPTM_A459_Selumetinib_30min_R1 1 ASCGPPSLPDPTFLPDAER 19 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 ASCGPPS(0.939)LPDPT(0.06)FLPDAER 74.812 0.0096602 3599000.0 375.6 664.01 545.61 689.8 729.3 449.05 550.16 482.68 295.69 348.45 True False 384.3507492096242 586.2674005101255 471.5191588212015 569.3393791496812 663.3349437683728 444.53296470477784 508.660988263643 469.8777584343958 501.7643336568667 393.17695169042463 0.9775515771134268 1.491103173747922 1.1992543224976755 1.4480487136945948 1.6871155364434032 1.1306180659714493 1.2937202602459437 1.1950796108830992 1.2761794187059583 1.0 8.61903494213347 -8.774430351569654 0.6728070816343564 1.0018110648266865 1.3399567887543213 0.19056634243180137 0.18949974260639166 1.7779932903226785 1.650799067263684 0.19807352689353183 0.07426195671992375 1.6810074896804878e-09 8.774430351569654 0.33814572392763487 ASDPAS(ph)PHIGR ddPTM_A459_Selumetinib_30min_R1 1 ASDPASPHIGR 11 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 ASDPAS(1)PHIGR 114.76 0.0063725000000000006 10890000.0 4275.4 4500.3 4610.9 4536.7 5295.0 3714.0 4377.5 4250.4 1826.6 3333.1 True False 4375.008501519774 3973.402783867292 3984.765105860736 3744.450509406149 4816.068184908177 3676.6405320421923 4047.3016506545287 4137.665584755025 3099.606790414397 3760.93585214336 1.1632765549634283 1.0564931017376558 1.0595142439320828 0.9956166913275546 1.2805504731391513 0.9775866105099539 1.076142165080526 1.100169146037672 0.8241583776676034 1.0 11.876875984131532 -8.245598480407367 24.773500005851915 0.9120791896405113 1.085798349460665 0.3806250250258101 0.09004628457988569 627.2911347989947 981021.6341571542 0.05831257122352364 0.02187923706845648 5.68069561773775e-09 8.245598480407367 0.17371915982015362 ASDPAS(ph)PHIGR ddPTM_A459_Selumetinib_30min_R2 1 ASDPASPHIGR 11 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 ASDPAS(1)PHIGR 89.992 0.018822 25602000.0 137680.0 129670.0 171120.0 165220.0 181660.0 118230.0 118220.0 119760.0 101010.0 114100.0 True False 130028.29677670849 139615.2720452339 160110.32550136844 142716.75097960274 158838.24673899487 134515.10931491852 123717.46424848585 120108.48177266476 121214.82245521114 110805.63653259764 1.1734808882078467 1.2600015343457807 1.4449655316430223 1.2879917975798754 1.4334852604024944 1.2139735262957119 1.1165268132554764 1.0839564261456172 1.0939409424316717 1.0 16.757671745632543 -7.152435077349054 2.670778493985892 1.0748444628056946 1.3219459557136248 0.6776187254724413 0.07974795845493766 0.17604071515774788 2.4403218810189293 0.03549338415578768 0.025803152069588883 7.039874591055229e-08 7.152435077349054 0.24710149290793026 ASDPQS(ph)PPQVSR ddPTM_A459_Selumetinib_30min_R1 3 ASDPQSPPQVSR 12 0 Q7L7X3;Q7L7X3-3;Q7L7X3-2 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 ASDPQS(0.999)PPQVSR;ASDPQS(0.99)PPQVS(0.009)R;AS(0.006)DPQS(0.994)PPQVSR 113.54 0.0059139 99169700.0 7220.0 7594.5 8504.5 8163.5 7922.5 6214.700000000001 7988.200000000001 7399.6 4038.4700000000003 5941.1 True False 7388.211952325579 6705.332409412732 7349.635611874611 6737.897972873917 7205.911273830982 6152.185760496122 7385.643642663283 7203.338570711759 6852.988631821325 6703.698056214611 1.1021098937289389 1.0002437987487527 1.0963554071563812 1.0051016493243756 1.0749158469556663 0.9177301407232664 1.1017267753902609 1.0745320732388834 1.02226988363062 1.0 12.710741454192794 -4.739868835707949 24.250872953364976 1.0359058988491494 1.1021102591307061 0.1292366204503932 0.05353658751535253 2515.7029998946905 2828086.2581712482 0.012759179382626913 0.5639147360832207 1.8202505221012523e-05 4.739868835707949 0.06620436028155674 ASDPQS(ph)PPQVSR ddPTM_A459_Selumetinib_30min_R2 4 ASDPQSPPQVSR 12 0 Q7L7X3;Q7L7X3-3;Q7L7X3-2 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 AS(0.005)DPQS(0.994)PPQVS(0.001)R;ASDPQS(0.975)PPQVS(0.025)R;ASDPQS(0.991)PPQVS(0.009)R;ASDPQS(0.992)PPQVS(0.007)R 188.63 0.00012455 136852100.0 752486.0 667415.0 754484.0 756700.0 612131.0 519731.9 676011.0 638291.0 531858.0 490707.0 True False 710665.8405601266 718603.5844225334 705941.3208600663 653636.1546196908 535229.6312594268 591320.2515685548 707446.8509903839 640148.321135237 638244.4613541582 476539.0139000979 1.491306734245921 1.5079638045609884 1.4813924993936813 1.3716319872116907 1.1231601519443124 1.240864303489157 1.4845518002828069 1.3433282532234354 1.3393330718730205 1.0 18.86223480579369 -14.063791763715997 0.0830095128149897 2.3211823213911577e-15 1.6996963741140383 0.540149679689979 0.11047885841646533 204.27924581620877 1.30087427046396 39.586886834567736 4.006530019500549 8.633924294592324e-15 14.063791763715997 1.699696374114036 ASDSGPSSSSSS(ph)SSSPPR ddPTM_A459_Selumetinib_30min_R2 1 ASDSGPSSSSSSSSSPPR 18 0 Q16643-3 Q16643-3 DBN1 Drebrin 1 ASDSGPSS(0.005)S(0.007)S(0.079)S(0.079)S(0.656)S(0.019)S(0.079)S(0.076)PPR 136.39 0.00035173 2531200.0 5716.7 3532.8 5283.0 4066.9 5735.3 4112.9 4935.7 4414.5 3921.0 5343.3 True False 5398.9886997632875 3803.7544002575964 4943.097531695485 3512.9812042061853 5014.780339767456 4679.414641811117 5165.219829904007 4427.345464140184 4705.309561893692 5189.025045439329 1.040463025806456 0.7330383582559007 0.9526062195517843 0.6770021677374191 0.9664205309964696 0.901790721924514 0.995412391474918 0.8532133542179392 0.906781046668723 1.0 12.34124778389275 ASDSGPSSSSSSSSS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 ASDSGPSSSSSSSSSPPR 18 0 Q16643-3 Q16643-3 DBN1 Drebrin 1 ASDSGPSSSSSSSS(0.019)S(0.981)PPR;ASDSGPSSSSSSS(0.001)S(0.037)S(0.961)PPR 230.97 6.7149e-19 2180410.0 538.3000000000001 719.4200000000001 464.38 379.3 852.53 368.96000000000004 623.52 665.05 365.54 464.82 True False 550.8413426505344 635.1899719507159 401.3197466567502 313.0623753428155 775.418812026396 365.2485973888764 576.4873844011682 647.4107136131486 620.2946820147152 524.4841747302139 1.0502535046627064 1.2110755720655388 0.7651703635542151 0.5968957509611224 1.4784408174474641 0.6963958399254931 1.0991511511242527 1.2343760685366076 1.1826756876578493 1.0 9.034755432772352 -7.508924134985105 24.592632714399457 1.1584682973676368 0.9684093779035682 0.09427655853064176 0.24708246351424 1226.5001707471044 2161511.5189224547 0.10697736052807093 0.06875827791585341 3.097960421189294e-08 7.508924134985105 -0.1900589194640686 ASDSGPSSSSSSSSS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 ASDSGPSSSSSSSSSPPR 18 0 Q16643-3 Q16643-3 DBN1 Drebrin 1 ASDSGPSSSSSS(0.001)S(0.015)S(0.182)S(0.802)PPR 235.35 1.0624e-19 2288700.0 6331.1 6128.0 7515.1 7578.2 8447.3 6281.4 6754.4 9004.4 9124.3 8139.0 True False 5979.242807401359 6597.997895374364 7031.586647822217 6546.036086875832 7386.0746541798435 7146.605833128048 7068.492983589687 9030.601313241337 10949.41495424295 7904.005922338388 0.7564825818896159 0.8347663147274511 0.8896231501989985 0.8281922042056361 0.9344723076820121 0.9041751617278313 0.8942924705575732 1.1425347351675121 1.3852994369978384 1.0 12.948368312572155 -7.7924706345032595 3.6872969344780238 1.2133164343992107 0.8632362475548094 0.6815745641349727 0.09826171194349813 0.11845220815965558 3.366670594843721 0.05457425309970954 0.025607908797131623 1.612610062788473e-08 7.7924706345032595 -0.35008018684440123 ASDSS(ph)SPSCSSGPR ddPTM_A459_Selumetinib_30min_R2 1 ASDSSSPSCSSGPR 14 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 AS(0.003)DS(0.004)S(0.614)S(0.376)PS(0.002)CS(0.001)SGPR 163.62 0.00026676 52745000.0 14397.0 13527.0 15651.0 14685.0 15602.0 9224.7 10322.0 10535.0 9451.2 12502.0 True False 13596.872375757346 14564.477403839586 14644.031699520352 12684.877666962015 13641.937276350298 10495.318691510854 10801.993452654977 10565.655105836866 11341.704088592112 12141.034775902997 1.1199105040654223 1.1996075847461152 1.2061600983620602 1.0447937841458468 1.1236222882275428 0.8644500971483511 0.8897094565690816 0.8702433771796061 0.9341628862724813 1.0 13.56760376674796 -6.735594383367778 8.483435101858554 0.9022037171694577 1.1412041205268564 0.8062964700081042 0.05555568298381959 0.09351729789364724 26.52497096283296 0.019039678248517985 0.018724942874664967 1.8382544104579598e-07 6.735594383367778 0.2390004033573987 ASDSSS(ph)PSCSSGPR ddPTM_A459_Selumetinib_30min_R1 2 ASDSSSPSCSSGPR 14 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 AS(0.005)DS(0.002)S(0.09)S(0.686)PS(0.041)CS(0.148)S(0.029)GPR;AS(0.003)DS(0.011)S(0.094)S(0.887)PS(0.005)CSSGPR 159.58 0.0002972 14437360.0 806.74 1163.73 1193.09 1253.29 767.35 892.05 871.5400000000001 872.28 559.39 1150.16 True False 825.5354723572206 1027.4799505966012 1031.0749311742586 1034.4264286670116 697.9433279866457 883.0767869165956 805.7990361191207 849.144300835242 949.2439737708913 1297.7942395071277 0.6361065931921072 0.7917125221535999 0.7944825919136743 0.7970650486627702 0.537791975599852 0.6804443724854009 0.6208989157057321 0.6542980967134878 0.7314287156424676 1.0 10.341845952148875 -8.622810329867443 8.344507663143434 0.9999999645961153 0.6920600176622498 0.5692550470026938 0.08062345348119546 5.810893880203906 485.610868018965 0.08392570057492729 0.02168881154393953 2.3833601308277963e-09 8.622810329867443 -0.3079399469338655 ASDSSS(ph)PSCSSGPR ddPTM_A459_Selumetinib_30min_R2 3 ASDSSSPSCSSGPR 14 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 AS(0.002)DSS(0.07)S(0.925)PS(0.003)CSSGPR;AS(0.009)DSS(0.13)S(0.844)PS(0.014)CS(0.002)S(0.001)GPR;ASDSS(0.023)S(0.952)PS(0.023)CS(0.002)SGPR 244.71 4.0624e-20 63609800.0 45801.4 43402.3 46166.5 46150.100000000006 49706.8 36495.0 36624.6 40365.5 36987.2 44154.5 True False 43255.941545531205 46731.116849609454 43196.19765228461 39864.376766637004 43462.187399569884 41521.85498137483 38327.716470268104 40482.95692213176 44385.67350871575 42879.64485783148 1.0087756484212345 1.089820519842168 1.007382355789155 0.9296806654721215 1.0135855262717273 0.9683348618917336 0.8938440744400891 0.944106628129827 1.0351222277114829 1.0 15.388005336558589 -5.522741617889329 7.763458680235095 0.9657118459151945 1.0493127545218826 0.3565131708700454 0.04302113214826127 0.11407765266509538 56.31492911445153 0.011630059884632511 0.021527592965108408 3.0009473920195863e-06 5.522741617889329 0.08360090860668801 ASEAAS(ph)PLPDSPGDK ddPTM_A459_Selumetinib_30min_R1 2 ASEAASPLPDSPGDK 15 0 Q68CZ2;Q68CZ2-2 Q68CZ2 TNS3 Tensin-3 1 ASEAAS(1)PLPDSPGDK;ASEAAS(1)PLPDSPGDK 293.38 1.785e-67 50257000.0 8193.2 7564.5 5005.9 5587.1 5551.6 5993.7 6820.9 7474.6 4683.1 5440.9 True False 8384.08561880802 6678.844823359357 4326.126275440429 4611.417867856169 5049.458760214589 5933.408819844177 6306.394021461907 7276.34932707743 7946.878659908939 6139.2925138540095 1.3656436144536819 1.0878850956014536 0.7046620218336289 0.7511318050817716 0.8224821913632415 0.9664645896012883 1.0272183655088618 1.1852097469956877 1.2944290636056037 1.0 12.583856695051754 -7.560364979204132 2.6175930262992897 1.180701867205789 0.9305884450777107 0.1917431176165958 0.18874095291983242 0.4501196353698187 6.213599692594236 0.11288992970484675 0.05991055480551495 2.7519150337838976e-08 7.560364979204132 -0.2501134221280783 ASEAAS(ph)PLPDSPGDK ddPTM_A459_Selumetinib_30min_R2 4 ASEAASPLPDSPGDK 15 0 Q68CZ2;Q68CZ2-2 Q68CZ2 TNS3 Tensin-3 1 AS(0.023)EAAS(0.977)PLPDSPGDK;ASEAAS(1)PLPDSPGDK;AS(0.051)EAAS(0.949)PLPDSPGDK;ASEAAS(1)PLPDSPGDK 230.96 6.21e-14 54566400.0 210859.0 170590.0 191070.0 221093.0 229332.0 211430.0 287973.0 294893.0 254145.0 247629.0 True False 199140.30091545603 183673.7044666957 178776.76422128643 190979.75199330135 200521.26390590714 240552.5633295545 301364.3151076744 295751.089807836 304981.1014046088 240479.30735259084 0.828097448831539 0.7637817427567406 0.7434184927984838 0.7941629327519926 0.83383999277702 1.000304624866772 1.2531818992052148 1.2298400767356072 1.2682218057017498 1.0 17.87555323344602 -6.942643724853681 2.2778317890069246 1.2075145046860962 0.782013592723367 0.8596908220053512 0.07509355255765088 0.09662858617337432 1.0157741893191021 0.029819587613399957 0.024455403007681495 1.1411855796418328e-07 6.942643724853681 -0.4255009119627292 ASEAAS(ph)PLPDSPGDKLVIVK ddPTM_A459_Selumetinib_30min_R1 2 ASEAASPLPDSPGDKLVIVK 20 1 Q68CZ2;Q68CZ2-2 Q68CZ2 TNS3 Tensin-3 1 AS(0.028)EAAS(0.963)PLPDS(0.009)PGDKLVIVK;AS(0.103)EAAS(0.897)PLPDSPGDKLVIVK 82.21600000000002 0.0018667 64953000.0 9217.7 7859.9 14575.4 15118.2 10894.3 9553.3 9548.4 9792.0 7017.9 6251.5 True False 9432.454475478042 6939.659254031624 12596.1407369413 12478.090173761555 9908.912488544885 9457.20247570238 8828.156500539055 9532.284351101349 11908.863732863902 7053.940919766647 1.3371893219358122 0.9837988909979695 1.785688437174775 1.7689530314600856 1.4047342614931746 1.3406977154006607 1.2515211852428019 1.351341676875951 1.6882568011723382 1.0 12.784213777194523 -6.519819710756268 23.71527245593086 1.3468747635325677 1.4731289289194447 0.058964299111728846 0.26251533669250815 251.29786606678724 1948238.161634309 0.09057507872509288 0.09241987255362599 3.021205657217494e-07 6.519819710756268 0.12625416538687695 ASEAAS(ph)PLPDSPGDKLVIVK ddPTM_A459_Selumetinib_30min_R2 2 ASEAASPLPDSPGDKLVIVK 20 1 Q68CZ2;Q68CZ2-2 Q68CZ2 TNS3 Tensin-3 1 AS(0.025)EAAS(0.975)PLPDSPGDKLVIVK;AS(0.075)EAAS(0.925)PLPDSPGDKLVIVK 84.895 0.0013720999999999998 8777900.0 76221.0 104304.0 97635.0 122208.0 110651.0 69376.0 65999.0 66385.0 51231.0 133685.0 True False 71984.94195683826 112303.78140977929 91353.2703969504 105563.05957944106 96750.03214750905 78931.91426737537 69068.0842745375 66578.16935937168 61478.63151374035 129825.166694656 0.5544760217881652 0.8650386074520793 0.7036638020408624 0.8131170732691719 0.7452332595502191 0.6079862346953139 0.5320084389876663 0.5128294540607914 0.4735494132531008 1.0 16.986210552274606 -6.790146612999325 5.035634842554703 0.5870965425644362 0.7465263566438298 0.0856486821442104 0.15787147003276084 0.3144326192087768 19.937994226038313 0.05244026258789798 0.047729543387126844 1.6212626846667367e-07 6.790146612999325 0.1594298140793936 ASEAASQAS(ph)PSAVTSKPR ddPTM_A459_Selumetinib_30min_R1 2 ASEAASQASPSAVTSKPR 18 1 A0A286YF23;A0A0J9YY01;A0A2R8YFM0;Q96JP2 A0A286YF23 MYO15B Unconventional myosin-XVB 1 ASEAAS(0.011)QAS(0.968)PS(0.021)AVTSKPR;ASEAAS(0.067)QAS(0.921)PS(0.012)AVTSKPR 188.26 4.2924e-14 10131000.0 1810.23 1893.8899999999999 1999.37 2224.72 2195.16 1881.78 1898.69 1950.38 1013.71 1417.02 True False 1852.4048369055852 1672.1524783544264 1727.8665357532764 1836.2144151665395 1996.608165586976 1862.8510017195347 1755.4702846559114 1898.649586672902 1720.191831550957 1598.9083199436516 1.1585434973350237 1.0458088543896977 1.0806539150500947 1.148417574830839 1.2487321134568492 1.1650768080218539 1.0979180374255464 1.1874661999005758 1.075853949907259 1.0 10.642871502933371 -8.536371794932725 5.562300871528617 1.0000394386732863 1.139262620727107 0.4056205699922597 0.05414888701432572 0.15917380933618885 25.197950412445763 0.0568626312336237 0.014757157860603068 2.9082263501046608e-09 8.536371794932725 0.13922318205382078 ASEAASQAS(ph)PSAVTSKPR ddPTM_A459_Selumetinib_30min_R2 1 ASEAASQASPSAVTSKPR 18 1 A0A286YF23;A0A0J9YY01;A0A2R8YFM0;Q96JP2 A0A286YF23 MYO15B Unconventional myosin-XVB 1 ASEAASQAS(0.94)PS(0.058)AVT(0.001)SKPR 107.63 0.0074838 3419500.0 24172.0 20700.0 23949.0 30417.0 26945.0 21975.0 25132.0 24461.0 20215.0 26393.0 True False 22828.61700818272 22287.623439009352 22408.14741369963 26274.152127748286 23559.92820864368 25001.8567808114 26300.687798113253 24532.17746026345 24258.564854292545 25630.9655127506 0.8906655114816567 0.8695584810459817 0.874260760974934 1.025094123538878 0.9191978428172499 0.9754551293970475 1.0261294208768486 0.957130446297837 0.9464553663507007 1.0 14.64560020520278 -5.743931694540102 24.99994005819233 0.9760958237978226 0.8773012181927902 0.6741084648033394 0.03193656394427306 143.2919347026745 204610.7734398638 0.008641151636779284 0.014923077065320882 1.8033013402295014e-06 5.743931694540102 -0.09879460560503239 ASEDS(ph)EEEPSGK ddPTM_A459_Selumetinib_30min_R1 1 ASEDSEEEPSGK 12 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 ASEDS(0.982)EEEPS(0.018)GK 157.52 0.00056776 0.0 2005.8 1525.3 2046.6 2308.8 1781.3 1945.3 2210.1 1729.2 1207.9 1542.8 True False 2052.5312373926095 1346.7171669072686 1768.6829611690953 1905.6114215436144 1620.1817295140577 1925.7320481910795 2043.390377638281 1683.3359987667948 2049.718078474516 1740.8334081446037 1.1790509234196145 0.7736048496120098 1.0159978277612296 1.0946546709340974 0.9306931507253542 1.106212713509182 1.1738000707466576 0.966971331599679 1.177434939428882 1.0 10.765562433232269 -6.778709917983084 24.991112103696974 1.0883768063989108 0.992570082694763 0.11872894769800058 0.11645433576538002 493.8959173251333 714681.2966654841 0.03947069481930224 0.034890586780215525 1.6645240789087906e-07 6.778709917983084 -0.09580672370414778 ASEDS(ph)EEEPSGK ddPTM_A459_Selumetinib_30min_R2 1 ASEDSEEEPSGK 12 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 ASEDS(1)EEEPSGK 168.76 0.00037535 6162100.0 26770.0 27265.0 30969.0 27825.0 30671.0 19005.0 25695.0 23679.0 17518.0 23397.0 True False 25282.230568800744 29356.137829207266 28976.48825649774 24035.186999197696 26817.834777781056 21622.766239787055 26889.86841367658 23747.901969730534 21022.08949381631 22721.467817293422 1.1127023470534025 1.292000062023465 1.2752912131162404 1.0578184117535046 1.180286194247093 0.9516447798909303 1.1834564839693398 1.0451746410351135 0.9252082507546583 1.0 14.471768416167102 -6.547282681863805 0.5680020425664676 0.993371670749384 1.2422880923058413 0.4371167214586945 0.09141245253957689 0.9112611663044633 0.6353513138294999 0.07343391099507492 0.1083516027266602 2.8360724306938453e-07 6.547282681863805 0.2489164215564572 ASEDTTSGS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 5 ASEDTTSGSPPK 12 0 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 1 ASEDTTS(0.002)GS(0.998)PPK;ASEDTT(0.014)S(0.083)GS(0.903)PPK;ASEDT(0.001)T(0.014)S(0.083)GS(0.903)PPK;ASEDT(0.001)T(0.003)S(0.003)GS(0.994)PPK;AS(0.001)EDT(0.005)T(0.032)S(0.032)GS(0.931)PPK 194.06 0.0001042 281709000.0 27809.54 32951.240000000005 36212.9 36772.5 24645.820000000003 27827.78 26795.4 26590.5 16718.910000000003 26223.100000000002 True False 28457.44817405486 29093.293502184137 31295.387083221143 30350.873180315557 22416.60993257293 27547.857798802637 24774.201404899708 25885.233561883226 28370.76916912691 29589.090319624553 0.961754750370979 0.9832439317300814 1.0576664150592325 1.0257453964438292 0.757597130916371 0.9310140156803639 0.8372748583104822 0.8748235678173318 0.9588253259110975 1.0 14.852777722869382 -6.20855202635782 24.999961570787907 0.8860856453711193 1.0090102079994014 0.40701360431804356 0.06696956272664974 304.9841773508646 144166.40098708431 0.01908228437896553 0.02463510610214543 6.186542113609557e-07 6.20855202635782 0.12292456262828211 ASEDTTSGS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 4 ASEDTTSGSPPK 12 0 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 1 ASEDT(0.012)T(0.012)S(0.023)GS(0.952)PPK;ASEDTTS(0.002)GS(0.998)PPK;ASEDT(0.008)T(0.017)S(0.017)GS(0.959)PPK;ASEDTT(0.001)S(0.001)GS(0.998)PPK 201.09 8.465700000000001e-05 220376000.0 164199.0 146424.0 154093.0 141886.0 143638.0 105278.0 132688.0 133961.0 91650.0 127690.0 True False 155073.47692067648 157654.2499726333 144178.82414377297 122560.88203299772 125592.91029998759 119779.0888814683 138858.25491628385 134350.80433156248 109982.56091495995 124003.25792153672 1.2505596991556422 1.2713718382495185 1.162701904453207 0.988368241990451 1.0128194404332242 0.9659350156530463 1.1197952154139907 1.0834457625022498 0.8869328335272579 1.0 16.92001849928687 -5.574977607084114 3.237137912584342 1.0147385680003735 1.2574036922929037 0.7464619231386553 0.060298551937555143 0.1223292722396015 2.6043601089313686 0.01732519688812129 0.034464146072396035 2.6608622545618665e-06 5.574977607084114 0.24266512429253018 ASEDTTSGS(ph)PPKK ddPTM_A459_Selumetinib_30min_R1 3 ASEDTTSGSPPKK 13 1 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 1 ASEDT(0.332)T(0.155)S(0.121)GS(0.391)PPKK;ASEDT(0.039)T(0.011)S(0.104)GS(0.846)PPKK;AS(0.025)EDT(0.348)T(0.019)S(0.084)GS(0.525)PPKK 97.417 0.014253 4301085000.0 17267.8 18760.4 19809.2 22756.7 16340.1 17775.600000000002 16510.4 17647.399999999998 11011.5 16730.6 True False 17670.106142710185 16563.923646526662 17119.21944414681 18782.669541164913 14862.140840078962 17596.79360295347 15265.007235400697 17179.33362516605 18685.71125186037 18878.135479844495 0.9360090757678861 0.8774131144578005 0.9068278730399187 0.9949430419767086 0.7872674108068953 0.9321256128149377 0.8086077807683176 0.9100122013377755 0.9898070321515825 1.0 14.204428661896726 -8.237901980410074 4.213875993166147 0.9980676347933736 0.8914459596455174 0.3356826237459236 0.057101175661750644 0.22607452685415727 9.338593092747344 0.04556224696535891 0.014239517417461265 5.782265375107476e-09 8.237901980410074 -0.10662167514785614 ASEDTTSGS(ph)PPKK ddPTM_A459_Selumetinib_30min_R2 2 ASEDTTSGSPPKK 13 1 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 1 ASEDTTS(0.005)GS(0.994)PPKK;ASEDT(0.094)T(0.003)S(0.005)GS(0.897)PPKK 145.69 0.001114 197524000.0 45419.0 40237.0 42351.0 41465.0 42766.0 30389.0 38305.0 38811.0 28362.0 43541.0 True False 42894.793806662725 43323.0485176531 39626.18276828234 35817.39546888526 37393.35274710913 34574.808906124155 40086.258399917526 38923.93358449306 34035.19250049196 42283.85819689589 1.014448435781853 1.0245765255364871 0.9371468086890744 0.8470701822454475 0.8843410781718642 0.8176833993039532 0.9480274532483487 0.9205388354875931 0.8049216403575615 1.0 15.36781940119853 -5.427930827368023 3.400188404385974 0.8850145542273306 1.0193694938109632 0.45945782765873566 0.05581758400443358 0.1998551914845693 4.300341390987785 0.014622413643597138 0.03332753068643073 3.7330961227449786e-06 5.427930827368023 0.13435493958363265 ASEDTTSGSPPKK ddPTM_A459_Selumetinib_30min_R1 1 ASEDTTSGSPPKK 13 1 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 0 96.371 0.019264 5450000.0 1726.0 1671.0 2496.2 2322.4 1672.1 1598.8 1708.3 1791.3 1113.3 1598.1 False True 1766.2124417886353 1475.3585431731753 2157.2297506451173 1916.8364368472317 1520.8588502332318 1582.7175235942516 1579.4415556397796 1743.7889050375677 1889.1887877851457 1803.2317018122185 0.9794706027038126 0.8181746925203589 1.1963131240855718 1.0630006309898181 0.8434073384495145 0.8777116784291482 0.875894957953804 0.9670354083089202 1.0476683533716393 1.0 10.816369068885813 -4.396174442748138 21.689917708393896 0.9614302249285595 11.083604758056113 0.00024175605006049317 0.11100414873235605 9780.989834667767 1684525.7268502396 0.028240700401864466 29946.012234001268 4.016294562344382e-05 4.396174442748138 10.122174533127554 ASEENLLSSSSVPSADRDS(ph)SPTTNSK ddPTM_A459_Selumetinib_30min_R1 2 ASEENLLSSSSVPSADRDSSPTTNSK 26 1 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 ASEENLLSSSSVPS(0.009)ADRDS(0.383)S(0.383)PT(0.181)T(0.044)NS(0.001)K;ASEENLLSSSSVPS(0.033)ADRDS(0.423)S(0.423)PT(0.097)T(0.023)NS(0.001)K 124.19 4.2173e-09 187246000.0 2970.0 2970.0 3758.5 4093.7999999999997 3104.4 2710.5 3567.1 3622.0 1653.73 2335.06 True False 3039.1952213860054 2622.2710192844593 3248.1163439626935 3378.8946801434727 2823.6075681263355 2683.2348309370905 3298.030775111315 3525.932794085897 2806.259026339649 2634.787696410512 1.1534877081468218 0.9952494551484717 1.2327810504002832 1.2824162966703885 1.0716641693647884 1.0183874907995738 1.251725434882047 1.3382227338048645 1.0650797520281197 1.0 11.363471003004523 -7.301158987827535 24.996390538855866 1.1919421763884233 1.1292757317388906 0.0015472635549468317 0.12092885326216897 1853.5299298625714 1166457.5703798125 0.05155283567051859 0.03475736855408185 4.998515143359021e-08 7.301158987827535 -0.06266644464953264 ASEENLLSSSSVPSADRDS(ph)SPTTNSK ddPTM_A459_Selumetinib_30min_R2 2 ASEENLLSSSSVPSADRDSSPTTNSK 26 1 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 ASEENLLSSSSVPS(0.001)ADRDS(0.496)S(0.496)PT(0.005)T(0.001)NSK;ASEENLLSSSSVPS(0.008)ADRDS(0.48)S(0.48)PT(0.025)T(0.006)NSK 131.33 3.1598e-09 221240000.0 189811.0 178438.0 191012.0 222330.0 213740.0 152124.0 164338.0 175031.0 123297.0 185985.0 True False 179262.06449363593 192123.62083139905 178722.49587814094 192048.27045935713 186888.070340156 173077.70015582064 171980.04262956922 175540.31123205816 147959.84520602028 180615.12980293727 0.9925085716197883 1.0637183110906505 0.9895211772853065 1.0633011236040644 1.0347309804226419 0.9582680052588038 0.95219067647993 0.9719025832641148 0.819199617260492 1.0 17.46255922427335 -6.880158098616188 3.0206262092614007 0.9347171538200116 1.0308510135146096 0.44476112414338964 0.04973676386848027 0.23620362028018482 4.320390866588556 0.01824329539218893 0.015878890284622946 1.3177769336215537e-07 6.880158098616188 0.09613385969459798 ASEGLDACAS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 ASEGLDACASPTK 13 0 Q92618 Q92618 ZNF516 Zinc finger protein 516 1 ASEGLDACAS(0.858)PT(0.142)K;AS(0.003)EGLDACAS(0.526)PT(0.471)K 168.67 0.00027382 20808500.0 5363.4 6253.0 7281.799999999999 7942.5 6321.9 5755.4 5752.5 5805.9 3472.2 4928.5 True False 5488.356784640303 5520.895853059167 6292.971556064262 6555.491474190119 5750.085261222099 5697.505901485086 5318.584293635677 5651.908671778932 5892.069800545753 5561.1209826553495 0.9869155520547042 0.9927667228025355 1.131601268106105 1.1788075631938462 1.033979530234302 1.0245247170948284 0.9563870863848991 1.0163254296043445 1.0595111703058797 1.0 12.441160008098226 -6.512037481608652 23.994321033351213 1.0111923073392917 1.075464269244288 0.19538941240332974 0.05846251205191253 552.3355930689747 1222456.6496761527 0.020748634983841704 0.022116053555061525 3.075831344911825e-07 6.512037481608652 0.06427196190499629 ASEGLDACAS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 3 ASEGLDACASPTK 13 0 Q92618 Q92618 ZNF516 Zinc finger protein 516 1 AS(0.006)EGLDACAS(0.783)PT(0.21)K;AS(0.004)EGLDACAS(0.97)PT(0.027)K;ASEGLDACAS(0.855)PT(0.145)K 180.27 5.899000000000001e-07 41990000.0 109686.0 100931.0 103437.0 102350.0 105862.0 72806.0 90044.0 94351.0 63428.0 99395.0 True False 103590.09122784759 108672.08315568388 96781.97603369015 88409.75343640211 92562.6691417122 82834.36563293535 94231.2244188012 94625.5457893512 76115.3723263946 96525.20809077595 1.0731921047031316 1.1258414802222914 1.0026601128139783 0.9159239869574614 0.9589481439362739 0.8581630360748334 0.9762343566271579 0.9803195213043392 0.7885543458742179 1.0 16.558618138907796 -5.5009978736320795 3.089912238927739 0.925473637214362 1.0988667002331507 0.5624503581026739 0.06115802230222338 0.17365923692286972 3.3446304345797437 0.01632384176723189 0.035625310523975384 3.1550200707664844e-06 5.5009978736320795 0.17339306301878865 ASEGLDACASPT(ph)K ddPTM_A459_Selumetinib_30min_R1 2 ASEGLDACASPTK 13 0 Q92618 Q92618 ZNF516 Zinc finger protein 516 1 AS(0.002)EGLDACAS(0.497)PT(0.501)K;ASEGLDACAS(0.267)PT(0.733)K 126.71 0.0046791 20669500.0 7868.1 9470.400000000001 9527.8 10057.099999999999 7925.7 7980.1 8870.7 7667.1 4646.9 6791.7 True False 8051.411421342501 8361.601165330489 8233.977092459165 8300.816280148249 7208.821834395985 7899.827439351069 8201.575957158459 7463.743601749307 7885.449903852331 7663.480851760245 1.0506206744802071 1.0910970258912946 1.0744434874614297 1.0831652666348885 0.94067199668675 1.0308406313218017 1.0702154955178909 0.9739364847548279 1.0289645210036769 1.0 12.90378411635736 -6.1959802364065135 24.999672851474706 1.0104436054370678 1.0759657970498557 0.483800536199402 0.0340105116582729 180.45810109097886 68918.94130384029 0.010028533198406034 0.012946777562985734 6.368245004476093e-07 6.1959802364065135 0.06552219161278794 ASEGLDACASPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 ASEGLDACASPTK 13 0 Q92618 Q92618 ZNF516 Zinc finger protein 516 1 ASEGLDACAS(0.411)PT(0.589)K 160.78 0.00085094 4275100.0 16540.0 17816.0 18325.0 19103.0 18578.0 14219.0 12558.0 14056.0 10638.0 17155.0 True False 15620.773014866056 19182.429912530948 17145.989450751422 16501.13844548693 16244.065550572748 16177.538182769402 13141.971883204917 14096.90063290393 12765.897250554743 16659.690575957127 0.9376388441097212 1.1514277426145345 1.0291901504759104 0.9904828886378588 0.97505205612977 0.9710587425985236 0.7888484977128627 0.8461682147475322 0.766274571088264 1.0 14.02407398501415 -6.939932877227179 1.733896006575668 0.8375125209970473 1.0318292254978914 0.4822215922414602 0.07964826318231867 0.2758893615082171 1.6896449997336649 0.035114979878319415 0.0279392231710997 1.148331089122693e-07 6.939932877227179 0.19431670450084404 ASEIDQVVPAAQS(ph)SPINCEK ddPTM_A459_Selumetinib_30min_R2 2 ASEIDQVVPAAQSSPINCEK 20 0 O94782;C9JWX4;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 ASEIDQVVPAAQS(0.585)S(0.415)PINCEK;ASEIDQVVPAAQS(0.506)S(0.494)PINCEK 111.4 0.00023303 2646200.0 89201.0 82374.0 88372.0 93373.0 93931.0 75655.0 80691.0 69530.0 66147.0 90627.0 True False 84243.56551989526 88691.82092584322 82686.24173215854 80655.43632259089 82130.54802620562 86075.78952228832 84443.29138618315 69732.32078868883 79378.24830160236 88010.36303277552 0.9572005229488999 1.0077429278733223 0.9395057454923319 0.9164311285996444 0.9331917878309373 0.9780187986525319 0.9594698678238155 0.7923194313233334 0.9019193372948761 1.0 16.425385787569304 ASEIDQVVPAAQS(ph)SPINCEKR ddPTM_A459_Selumetinib_30min_R2 1 ASEIDQVVPAAQSSPINCEKR 21 1 O94782;C9JWX4;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 ASEIDQVVPAAQS(0.5)S(0.5)PINCEKR 74.63 0.019056 0.0 21077.0 22088.0 25708.0 24069.0 23081.0 13454.0 13153.0 13849.0 11905.0 21238.0 True False 19905.62471791608 23782.078575885913 24053.97526875403 20790.76067865909 20181.35843324197 15307.166376747982 13764.640562175062 13889.29829717462 14286.33265349258 20624.803757049096 0.9651303814763708 1.1530814477571807 1.1662644431481157 1.0080464727599299 0.9784994160899317 0.7421727041410678 0.667382862126415 0.6734269310284986 0.6926772648011175 1.0 14.33209277187377 -6.6105925488379125 2.168139692666984 0.7241718182630944 1.0873916359493205 0.6620808974941372 0.10721084582726799 0.16768547032050954 1.6054195822778776 0.03874701660237543 0.039404791906868054 2.4513620090406687e-07 6.6105925488379125 0.36321981768622613 ASEIDQVVPAAQSS(ph)PINCEK ddPTM_A459_Selumetinib_30min_R1 2 ASEIDQVVPAAQSSPINCEK 20 0 O94782;C9JWX4;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 ASEIDQVVPAAQS(0.129)S(0.871)PINCEK;ASEIDQVVPAAQS(0.066)S(0.934)PINCEK 106.99 0.00030349 17847100.0 4431.700000000001 4993.9 4422.6 4664.0 4595.4 4056.4 4550.0 4375.8 2479.9 3694.2 True False 4534.949987412916 4409.211866398877 3822.035211602876 3849.5199541231023 4179.746881383763 4015.596298916515 4206.789836773986 4259.739569398416 4208.209175270264 4168.386554555221 1.087938925063731 1.0577742271960073 0.9169099750180676 0.9235035915554279 1.0027253534862615 0.9633454686509972 1.009212984860245 1.021915677360432 1.0095534855498285 1.0 12.025273356539751 -7.489087543684139 23.281502886083825 1.0125536345168564 0.9887526695346723 0.027620685623355734 0.05011557430542784 1087.6185930646052 749351.2709293148 0.023196516762723066 0.015622345186486603 3.242742446020168e-08 7.489087543684139 -0.023800964982184092 ASEIDQVVPAAQSS(ph)PINCEKR ddPTM_A459_Selumetinib_30min_R1 1 ASEIDQVVPAAQSSPINCEKR 21 1 O94782;C9JWX4;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 ASEIDQVVPAAQS(0.237)S(0.763)PINCEKR 137.04 1.6000999999999998e-05 11416000.0 2961.6 2581.5 6378.4 5509.2 3917.4 3172.2 2985.4 3130.2 2049.7 2180.5 True False 3030.5995177295604 2279.2567798932105 5512.248314043272 4547.1216404920615 3563.071861673142 3140.290548127148 2760.2088744406715 3047.176927677436 3478.191195835098 2460.3884148686197 1.2317565386891927 0.926380877961872 2.24039760581364 1.8481316254835598 1.448174540304606 1.2763393491652553 1.1218589950107782 1.2384942593871504 1.4136756517042968 1.0 11.264670372572475 -6.7015172072964715 3.451810945769566 1.2147939774320888 1.5715802254979316 0.19467586339828524 0.3398837570576457 0.4486453876663586 10.815967193021757 0.130473114185155 0.12606426837439977 1.988304029716504e-07 6.7015172072964715 0.3567862480658428 ASENSES(ph)EYSR ddPTM_A459_Selumetinib_30min_R2 1 ASENSESEYSR 11 0 Q8IXW5-2;Q8IXW5 Q8IXW5-2 RPAP2 Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 1 ASENS(0.383)ES(0.452)EYS(0.165)R 102.33 0.012864 0.0 6661.0 6707.7 8343.1 8978.0 8249.4 9805.5 9982.8 7632.8 7078.2 9293.2 True False 6290.808286095697 7222.159021345076 7806.314029280451 7755.180912086141 7213.0366214282885 11156.118619533394 10447.01998054293 7655.010184321934 8494.037781432278 9024.881169366648 0.6970516473334547 0.8002497634937742 0.8649769324140902 0.8593111384568387 0.7992389579501231 1.2361513032881641 1.1575797824356377 0.8482117426992283 0.9411800135677992 1.0 13.139692220817675 -6.717963122767722 24.980133868229498 1.034697703437427 0.8103898762657566 0.5315772507582369 0.10902104909362785 124.42792187797157 71492.06979872972 0.03931422516185998 0.03931399100621158 1.9144184770693386e-07 6.717963122767722 -0.2243078271716703 ASEPLLS(ph)PPPFGESR ddPTM_A459_Selumetinib_30min_R1 4 ASEPLLSPPPFGESR 15 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ASEPLLS(1)PPPFGESR;ASEPLLS(1)PPPFGESR;ASEPLLS(1)PPPFGESR;ASEPLLS(1)PPPFGESR 202.32 1.3055e-05 77670600.0 4890.51 5637.509999999999 6447.8 6224.62 6319.49 5182.36 6398.18 6870.299999999999 4106.26 4393.68 True False 5004.449367724063 4977.467708392706 5572.224175230189 5137.606967588707 5747.893245296576 5130.2301636064 5915.56013139573 6688.077326120467 6968.023310635623 4957.651626067395 1.0094394978079149 1.0039970703510344 1.1239644483955595 1.0362985048354556 1.1593983762542088 1.0348105414732218 1.1932181963516033 1.34904140721677 1.4055088651242995 1.0 12.275441181539874 -7.460797054057533 3.901107629323585 1.2826282655774053 1.065646485413426 0.3764900484931275 0.10995658514468931 0.20792526881668627 6.264090960587323 0.048622917278246476 0.030285369285598975 3.461010731789886e-08 7.460797054057533 -0.2169817801639793 ASEPLLS(ph)PPPFGESR ddPTM_A459_Selumetinib_30min_R2 4 ASEPLLSPPPFGESR 15 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 AS(0.001)EPLLS(0.999)PPPFGESR;ASEPLLS(1)PPPFGESR;ASEPLLS(1)PPPFGESR;ASEPLLS(1)PPPFGESR 205.66 2.5661000000000003e-06 58406500.0 129978.0 128287.0 150594.0 151765.0 163291.0 125617.6 125521.0 136696.0 128904.0 175779.0 True False 122754.34310315968 138126.20039227995 140904.94599434966 131094.34519077215 142776.92473993823 142920.2841569626 131357.97521514297 137093.76272875888 154688.4018786905 170703.80354130996 0.7191072521910936 0.8091571337416258 0.825435304142189 0.7679638207888414 0.836401543363306 0.8372413572048861 0.769508191909471 0.8031090103717723 0.9061801709723254 1.0 17.381135678608274 -14.522878745280142 0.15801589670483976 1.738059672536545 0.7529420030840536 0.7315770699139814 0.03867127595002833 71.81362357709116 0.6541117867864872 16.46642381550434 0.17268428812188688 3.0000000000013508e-15 14.522878745280142 -0.9851176694524914 ASEQETAKEEDGS(ph)VELESQVQK ddPTM_A459_Selumetinib_30min_R1 2 ASEQETAKEEDGSVELESQVQK 22 1 A0A087WVF1;Q96B23-2;Q96B23;K7EQH1 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 AS(0.002)EQET(0.055)AKEEDGS(0.937)VELES(0.007)QVQK;AS(0.019)EQET(0.041)AKEEDGS(0.9)VELES(0.041)QVQK 72.883 0.0014854 13772300.0 1774.27 2031.23 2026.44 2098.35 1773.24 2094.83 1999.49 1642.4 1040.03 1855.99 True False 1815.607038871565 1793.4126473067927 1751.2605784381421 1731.912563407849 1612.8507550909487 2073.757912153457 1848.6668595013646 1598.8382167329303 1764.8549492142151 2094.224395373543 0.8669591677389082 0.8563612625603595 0.83623349164824 0.8269947419359189 0.7701422821040472 0.9902271775339359 0.8827453560303032 0.7634512425053422 0.8427248546588635 1.0 11.032200319456116 ASES(ph)DAEIK ddPTM_A459_Selumetinib_30min_R2 1 ASESDAEIK 9 0 Q5M775;Q5M775-4;Q5M775-2;J3KSG2;Q5M775-5;Q5M775-3;J3KRN9;J3QQM0 Q5M775 SPECC1 Cytospin-B 1 AS(0.001)ES(0.999)DAEIK 96.756 0.0212 3583200.0 23393.0 20689.0 29575.0 28227.0 34321.0 25408.0 27577.0 30164.0 25948.0 24571.0 True False 22092.91070959864 22275.77977437994 27672.176698825275 24382.433905709026 30009.28914636706 28907.721369140207 28859.385142788848 30251.772246080964 31138.325047696402 23861.571386875115 0.9258782815012211 0.9335420292828062 1.1596963272102925 1.021828508709213 1.257640943247914 1.211476013060929 1.2094503197162758 1.2678030191557599 1.3049570182466614 1.0 14.542401433370667 -5.354548973654769 0.847626823461013 1.2226336417255905 0.8523442114074168 0.5324921695138032 0.09389518371417042 0.8443025660346123 0.8162339294852559 0.03601823368118864 0.25010000191562815 4.420292681893306e-06 5.354548973654769 -0.37028943031817374 ASES(ph)KY(ph)T(ph)K ddPTM_A459_Selumetinib_30min_R2 1 ASESKYTK 8 1 Q92545 Q92545 TMEM131 Transmembrane protein 131 3 AS(0.3)ES(0.7)KY(1)T(1)K 98.04 0.022722 0.0 15883.0 15336.0 18362.0 17313.0 25347.0 14178.0 12585.0 14434.0 12678.0 15551.0 True False 15000.286444686675 16512.22188698781 17180.60891103398 14954.939533409153 22162.68325494495 16130.890804930345 13170.227436704407 14476.000550322671 15213.95425291718 15102.002223649622 0.9932647487759165 1.0933796487680152 1.1376378215684062 0.9902620402207218 1.4675327765637827 1.0681292828622082 0.8720848561444342 0.9585484319194022 1.0074130587196075 1.0 13.882452214307513 -7.007375655000852 24.966384746569346 0.9580643781840852 1.1401586130330004 0.29655921887793846 0.12845304974898972 432.64599809011406 1464496.5294214769 0.047183836705130634 0.03995959796632858 9.831603261971889e-08 7.007375655000852 0.18209423484891518 ASES(ph)PARGPSGSPR ddPTM_A459_Selumetinib_30min_R1 2 ASESPARGPSGSPR 14 1 O43237-2;O43237;J3KRZ2 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 ASES(0.997)PARGPS(0.003)GSPR;AS(0.007)ES(0.993)PARGPSGSPR 164.53 0.0012337 11092000.0 2167.01 1251.8999999999999 3656.1200000000003 3396.93 3271.6800000000003 2048.29 1870.03 1537.27 1170.7 1293.48 True False 2217.4971167325534 1105.32696600748 3159.638985629608 2803.719943773453 2975.757121662019 2027.6860622985193 1728.9721315302102 1496.4966058432988 1986.5923954550178 1459.510757562147 1.5193427696528168 0.7573270428329915 2.1648617314114373 1.9209998482344646 2.0388730307356497 1.3892916182991402 1.1846244521130838 1.0253412645912456 1.3611358362121748 1.0 10.51126912916062 -6.9914638678034295 6.91995377094769 1.1632509595758842 1.6745188366086046 0.31682928658467224 0.3721433702459129 0.1979398316628294 50.091846428048036 0.14577727697146725 0.12414758305746906 1.0198496054091055e-07 6.9914638678034295 0.5112678770327204 ASESSKPWPDATYGTGS(ph)ASR ddPTM_A459_Selumetinib_30min_R2 2 ASESSKPWPDATYGTGSASR 20 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 ASESSKPWPDAT(0.005)YGT(0.104)GS(0.82)AS(0.071)R;ASESSKPWPDAT(0.001)YGT(0.114)GS(0.81)AS(0.074)R 89.39200000000002 0.0010129 30552000.0 63742.0 66513.0 80574.0 80339.0 76059.0 61393.0 74916.0 55502.0 59392.0 80619.0 True False 60199.47481944326 71614.33322699665 75389.95656233812 69396.68960749479 66503.78844391284 69849.32847983412 78399.74244323777 55663.501631149236 71272.05955113238 78291.31999668252 0.7689163348120088 0.9147161298344593 0.9629414418550186 0.8863905936243682 0.8494401224392543 0.8921720630434368 1.001384859094978 0.7109792200911659 0.9103443338821268 1.0 16.256564747194844 -4.75641906241647 24.852366407627922 0.896512959521697 0.7689161221168147 0.19969556819540346 0.0796260125187191 251.76307148012998 1246164.9485195505 0.019394223170564315 0.1562459869366384 1.7521889516555188e-05 4.75641906241647 -0.12759683740488226 ASET(ph)PPPVAQPKPEAPHPGLETTLQER ddPTM_A459_Selumetinib_30min_R2 3 ASETPPPVAQPKPEAPHPGLETTLQER 27 1 Q6P1N0;Q6P1N0-2 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 AS(0.1)ET(0.9)PPPVAQPKPEAPHPGLETTLQER;AS(0.278)ET(0.722)PPPVAQPKPEAPHPGLETTLQER;AS(0.266)ET(0.734)PPPVAQPKPEAPHPGLETTLQER 68.587 0.00049468 38168400.0 113672.0 114464.0 111435.0 125128.0 128454.0 90441.0 93330.0 105789.0 92513.0 115455.0 True False 107354.56530506973 123243.02074023026 104265.39342125416 108085.35054216011 112316.46012666977 102898.42680834432 97670.02992988663 106096.82847568834 111018.1850291945 112121.51416188452 0.9574840841880522 1.0991915482187313 0.9299320848513744 0.9640018809066664 1.0017387025696405 0.9177402533092478 0.871108731093906 0.9462664616043487 0.9901595234336829 1.0 16.774703607144005 -5.288652771291541 24.96855767794606 0.9487035298012502 1.0283378510725978 0.26757064929305885 0.04977468001455428 779.158421177561 714884.4070554732 0.013049320343604672 0.027177107865759813 5.1445480597987855e-06 5.288652771291541 0.07963432127134762 ASETDTHS(ph)IGEK ddPTM_A459_Selumetinib_30min_R1 1 ASETDTHSIGEK 12 0 F6RP06;A0A0J9YW18;Q12983 F6RP06 BNIP3 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 1 ASETDT(0.002)HS(0.998)IGEK 137.81 0.0012934 4159600.0 1106.3 1099.1 1826.6 1364.9 1331.2 1039.9 959.83 1079.0 690.68 819.79 True False 1132.0746375149283 970.4168610422726 1578.5577527955977 1126.5458373461875 1210.7931950424481 1029.4395501536542 887.4292503364343 1050.3814149140478 1172.0335147286858 925.0180319308168 1.2238406154655346 1.0490788585133777 1.7065156551603957 1.2178636507168576 1.308940099810946 1.1128859272125489 0.9593642715094727 1.135525339675332 1.2670385595427436 1.0 9.853337678996763 -6.7807850605830176 5.796313177765995 1.093427551530677 1.305740606801018 0.26215524468890194 0.1731221627957849 0.2504424945379962 26.400755205764042 0.06173417990835636 0.0564523538945355 1.65658963382664e-07 6.7807850605830176 0.21231305527034094 ASETDTHS(ph)IGEK ddPTM_A459_Selumetinib_30min_R2 1 ASETDTHSIGEK 12 0 F6RP06;A0A0J9YW18;Q12983 F6RP06 BNIP3 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 1 AS(0.022)ETDT(0.101)HS(0.876)IGEK 85.271 0.041631 0.0 11375.0 8796.9 9378.4 12609.0 11186.0 9813.4 13608.0 15650.0 8772.0 12183.0 True False 10742.823037732851 9471.593943508286 8775.00395442986 10891.63244826178 9780.714675891193 11165.106772824334 14240.798963740443 15695.538909003033 10526.645110158499 11831.245134764535 0.9080044336302778 0.8005576619892077 0.7416805124462921 0.920582096322066 0.8266851514344732 0.9436966815958499 1.2036602066417976 1.326617674659093 0.8897326519951275 1.0 13.530314292214614 -7.05621205725465 3.8418184696194317 1.1305197865456893 0.8384273036263452 0.5190069097866067 0.11922924226624775 0.17162698017843142 5.094270434863265 0.04630666320651387 0.036431574689337 8.785934125976396e-08 7.05621205725465 -0.2920924829193441 ASFDHS(ph)PDSLPLR ddPTM_A459_Selumetinib_30min_R1 2 ASFDHSPDSLPLR 13 0 H0Y6H0;Q8NB78;Q8NB78-2 H0Y6H0 KDM1B Lysine-specific histone demethylase 1B 1 AS(0.001)FDHS(0.998)PDS(0.001)LPLR;ASFDHS(0.998)PDS(0.002)LPLR 132.06 0.0016491 0.0 2036.0 2126.17 2668.0 2620.0 2860.7 2503.7 2528.3999999999996 2237.8 998.05 1728.49 True False 2083.4348386336387 1877.237027970384 2305.700254274968 2162.466183491106 2601.9501900976065 2478.5150511777156 2337.680752373481 2178.446274601165 1693.6179553121033 1950.3585284183732 1.0682317165158257 0.9625086878219838 1.1821930279376665 1.1087531610122678 1.3340881444026786 1.270799709419399 1.198590268564213 1.1169465730835435 0.868362370628096 1.0 10.929523639214569 -8.13739354462075 4.947143098792039 0.9372414917380487 1.1624207442311192 0.43349833820859895 0.10186230688588493 0.22900818683002458 8.017613944734512 0.08129950273962933 0.02912210576840888 7.287967971635526e-09 8.13739354462075 0.22517925249307047 ASFDHS(ph)PDSLPLR ddPTM_A459_Selumetinib_30min_R2 2 ASFDHSPDSLPLR 13 0 H0Y6H0;Q8NB78;Q8NB78-2 H0Y6H0 KDM1B Lysine-specific histone demethylase 1B 1 ASFDHS(1)PDSLPLR;ASFDHS(1)PDSLPLR 115.8 0.0026021 14807200.0 42735.0 42577.0 58045.0 71842.0 77134.0 55296.0 47163.0 53743.0 52828.0 60438.0 True False 40359.9597817594 45842.51899336721 54310.44789461754 62056.9956656375 67443.7373332909 62912.52207288953 49356.17295171156 53899.38323236738 63395.07613764861 58692.997903217525 0.6876452255567419 0.7810560140233379 0.9253309565848614 1.0573151463138257 1.1490934139111961 1.0718914405536046 0.8409209737948293 0.9183273159985007 1.0801131038183571 1.0 15.84090077908819 -5.256639456878738 2.2046707275089763 1.0131567820290863 0.6987200613951056 0.647924476410337 0.08313601115186445 0.23745316284528037 2.130295599152804 0.02609200462898188 0.09651368115553548 5.538096808199618e-06 5.256639456878738 -0.31443672063398076 ASFGATGGPPAHLLTPS(ph)PLSGPGGSSLLEK ddPTM_A459_Selumetinib_30min_R2 2 ASFGATGGPPAHLLTPSPLSGPGGSSLLEK 30 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 AS(0.001)FGAT(0.001)GGPPAHLLT(0.042)PS(0.763)PLS(0.026)GPGGS(0.078)S(0.089)LLEK;AS(0.002)FGAT(0.001)GGPPAHLLT(0.393)PS(0.538)PLS(0.048)GPGGS(0.011)S(0.008)LLEK 60.341 0.001709 3087000.0 8498.9 8780.2 11856.9 11666.4 13931.400000000001 10643.9 9662.6 10936.0 8072.2 9210.2 True False 8026.565161792323 9453.61310720724 11094.039962816621 10077.416194337471 12181.212983703786 12110.000609295947 10111.930046078662 10967.821949447747 9686.865556112794 8944.277595026539 0.8973966959897902 1.05694540523473 1.2403505867243496 1.1266886662754088 1.3619001483671689 1.3539383679269645 1.1305474297556906 1.2262389927998656 1.0830238052427141 1.0 13.126749249090212 -4.937520257771769 2.352520039673929 1.206492548731711 0.8711774142313785 0.40967166062192695 0.10887257753026897 0.3796642266204778 3.299163526380776 0.028879821084829078 0.23084070871425288 1.1547281208590869e-05 4.937520257771769 -0.33531513450033257 ASFGATGGPPAHLLTPSPLS(ph)GPGGSSLLEK ddPTM_A459_Selumetinib_30min_R2 1 ASFGATGGPPAHLLTPSPLSGPGGSSLLEK 30 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ASFGATGGPPAHLLTPS(0.138)PLS(0.797)GPGGS(0.032)S(0.032)LLEK 82.665 6.8447e-06 2314900.0 5701.2 6845.6 7880.6 7047.6 10047.0 7236.9 8646.2 6951.6 9169.7 9521.5 True False 5384.350127711868 7370.635507926687 7373.570775748524 6087.704722211889 8784.806038680395 8233.717284962639 9048.26543212028 6971.828005100671 11003.89622282494 9246.589555172006 0.5823066002426996 0.797119355622742 0.7974367989140576 0.65837298020942 0.9500590446092294 0.8904599080378965 0.97855164632664 0.7539891290190376 1.1900491697146867 1.0 13.174705635253167 -4.915211145561975 0.26923468503930703 1.043985236791733 0.3502358343509642 0.530130350203724 0.11642883989672699 7.019948415759479 0.45295077864147576 0.15044679319577828 1.613823164290443 1.2155948582909592e-05 4.915211145561975 -0.6937494024407689 ASFNHFDK ddPTM_A459_Selumetinib_30min_R2 1 ASFNHFDK 8 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 93.111 0.034453 9000300.0 70759.0 54438.0 71584.0 98150.0 102970.0 68154.0 86980.0 80870.0 93531.0 79202.0 False True 66826.49805071992 58613.21955424114 66978.36337476622 84781.80068180613 90033.98803652034 77541.59485958685 91024.74234760027 81105.31831125077 112239.81347449076 76915.23246849059 0.868833076440305 0.7620495664269477 0.870807527003248 1.1022758166470885 1.1705612158606429 1.0081435415455953 1.1834423354943358 1.054476671372952 1.459266388104221 1.0 16.23098172065643 -5.7465894184684885 3.3416973492985944 1.1436095561575963 0.8146252628533744 0.5636215726404608 0.12440354813265188 0.16480799219335932 3.8264334695483524 0.03416317213594563 0.05941708225743355 1.792299491320233e-06 5.7465894184684885 -0.32898429330422185 ASFNHFDR ddPTM_A459_Selumetinib_30min_R2 2 ASFNHFDR 8 0 P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;H7C5W8;F6THM6;H0YJ11;Q08043;A0A494C060;A0A087WSZ2;H0YJW3 P12814-4 ACTN1;ACTN2;ACTN3 Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 0 ; 123.21 0.008464900000000001 7692200.0 31670.0 24794.0 39615.0 52980.0 61556.0 37992.0 43378.0 47557.0 53007.0 35590.0 False True 29909.90818505488 26695.62007472453 37066.21402955076 45764.03260440233 53822.78496237784 43225.05314296185 45395.16295187636 47695.38299651482 63609.881139326455 34562.424226074836 0.8653880291906731 0.7723885309695558 1.0724425401151982 1.3240978788136248 1.5572630151843476 1.2506371908470382 1.3134253157401212 1.3799779403359131 1.8404345922974183 1.0 15.07691679196628 -5.599795940305903 2.364736584984895 1.4013198789153454 0.8185520849839151 0.5547351609149289 0.2043626815140147 0.20783707955735886 2.3312099389431036 0.05773280224375089 0.1253088022583298 2.513066955871441e-06 5.599795940305903 -0.5827677939314303 ASGDPGASGMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 ASGDPGASGMSPR 13 0 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR 198.81 0.00012725 199470800.0 24550.9 28554.2 28440.699999999997 29825.399999999998 29204.8 23662.399999999998 28498.300000000003 25570.0 13838.9 22990.9 True False 25122.888202264527 25211.060989512553 24578.609153582478 24616.953782097586 26563.23099652623 23424.3777397402 26348.65028688703 24891.800536934392 23483.602546734808 25942.005965330423 0.9684250414497404 0.9718238837507506 0.9474444338047712 0.9489225241485307 1.0239466844632612 0.9029516750186996 1.0156751302154527 0.9595171849933443 0.9052346444650005 1.0 14.66300241983075 -2.494014270340082 1.421397859347606 0.963222206673808 6.437978942830869 0.0015576807977297769 0.039136998204979005 15588.543684859196 55.17157086620723 0.010614292573595077 277609.07038480043 0.003206163972483157 2.494014270340082 5.474756736157061 ASGDPGASGMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 ASGDPGASGMSPR 13 0 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR;ASGDPGASGMS(1)PR 184.0 9.893e-05 211382000.0 212200.0 206245.0 224299.0 234319.0 254458.0 181180.0 177885.0 204842.0 186524.0 204948.0 True False 200406.7735039042 222063.32831780083 209867.84653828616 202404.34797717855 222490.71115661715 206135.9004117137 186157.0049724407 205438.05630658154 223834.01191600552 199030.61872114564 1.0069142868147671 1.1157244535772932 1.0544500533976844 1.016950805246502 1.1178717756404133 1.035699440298294 0.9353184257205085 1.0321932254775992 1.1246209922585377 1.0 17.60263086540259 -6.9898968186550565 24.980410831041095 1.0199720683155302 1.0638215345742774 0.1042583801985203 0.05459335400700587 461.83662527109624 1141901.875303878 0.019484125883841734 0.017162944313543028 1.023536139028462e-07 6.9898968186550565 0.043849466258747194 ASGGAQS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 3 ASGGAQSPLR 10 0 H7BZV9;C9JU48;D3YTC9;Q6NXT1 H7BZV9 ANKRD54 Ankyrin repeat domain-containing protein 54 1 ASGGAQS(1)PLR;ASGGAQS(1)PLR;ASGGAQS(1)PLR 110.64 0.0093376 135168000.0 8711.6 9215.5 8968.8 10169.0 10532.8 8805.599999999999 8657.7 8918.099999999999 5477.4 6673.200000000001 True False 8914.563330177212 8136.544975830286 7750.886222091957 8393.175045771404 9580.110099716878 8717.023658845097 8004.642718645739 8681.563017928616 9294.747746532259 7529.770222472499 1.1839090791338913 1.0805834355405528 1.029365570672999 1.1146654941371366 1.2722978014820647 1.1576745904980281 1.0630660009725117 1.1529651983295064 1.2343999181797352 1.0 12.87839012512936 -6.010044406203693 24.870045966756933 1.1546308896198945 1.0921823916617102 0.06487441912118974 0.08062862614615036 1056.643797441615 2616269.942692303 0.023232729622754772 0.032227354156263634 9.771373044742427e-07 6.010044406203693 -0.0624484979581843 ASGGAQS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 1 ASGGAQSPLR 10 0 H7BZV9;C9JU48;D3YTC9;Q6NXT1 H7BZV9 ANKRD54 Ankyrin repeat domain-containing protein 54 1 AS(0.001)GGAQS(0.999)PLR 82.774 0.04179 120220000.0 254390.0 221160.0 239020.0 321540.0 313450.0 233410.0 246020.0 292310.0 203910.0 263820.0 True False 240252.02220385554 238122.26085851766 223641.7134252991 277745.697312562 274071.60872144613 265560.10881497996 257460.41747938187 293160.5737054744 244697.6977214344 256202.83111332008 0.9377414806848509 0.9294286867313919 0.8729088295139916 1.0840851996272962 1.0697446532127608 1.0365229285757622 1.0049085576478487 1.1442518899246967 0.9550936523929476 1.0 17.966926892390298 -5.7628669248727515 24.9999999827938 1.0474687004580958 0.9149665577930548 0.5669566432949021 0.051398735338628904 24.92310142969273 436481.4605064677 0.013571770455332104 0.02142874284738105 1.7263667987505431e-06 5.7628669248727515 -0.132502142665041 ASGQAFELILS(ph)PR ddPTM_A459_Selumetinib_30min_R1 9 ASGQAFELILSPR 13 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;AS(0.001)GQAFELILS(0.999)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR 180.06 0.00011121 630951100.0 16468.829999999998 19481.21 21336.17 21275.18 21437.999999999996 17213.09 22022.48 21238.71 13766.810000000001 15932.029999999999 True False 16852.52169623518 17200.340876631184 18438.83530519263 17559.869197590204 19498.9366851863 17039.941942835252 20361.306603199635 20675.390417747116 23361.271081980103 17977.06124161398 0.9374458633552589 0.9567938077006259 1.0256868493338454 0.9767930899040359 1.0846565199460647 0.9478713853068793 1.1326270923562585 1.1500984582444955 1.299504450032275 1.0 14.133869578451243 -7.375365352763568 4.52358546534067 1.1639048045019436 0.9925775476104519 0.4865131669399564 0.07866852614948934 0.1874518816344538 6.160875895238025 0.033085198928813814 0.021740117906734593 4.2134189796568454e-08 7.375365352763568 -0.17132725689149164 ASGQAFELILS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 ASGQAFELILSPR 13 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR;ASGQAFELILS(1)PR 145.94 0.00061379 178274300.0 134358.7 138526.1 159544.6 167573.7 184031.4 142739.19999999998 152596.7 151429.9 161043.9 228910.8 True False 126891.58133449126 149150.60643838436 149279.67413502623 144749.8729792438 160911.73027040955 162400.22914255282 159692.74891462488 151870.53593843043 193257.17994252776 222301.55042231447 0.5708083506094791 0.6709382195267529 0.67151881690179 0.6511419857587908 0.723844390489943 0.7305402451491458 0.7183609318569784 0.6831735345521269 0.8693469729535847 1.0 17.76215848478455 -14.522878745023869 0.10308222135520637 2.036523826381332 0.49137580248547946 0.8602648817193246 0.04313309660257074 62.494003953209116 0.4336657338161641 13.611694960452564 0.6541575868532659 3.0000000017716237e-15 14.522878745023869 -1.5451480238958526 ASGS(ph)ENEGDYNPGR ddPTM_A459_Selumetinib_30min_R1 2 ASGSENEGDYNPGR 14 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 AS(0.009)GS(0.886)ENEGDY(0.105)NPGR;AS(0.143)GS(0.857)ENEGDY(0.001)NPGR 174.87 7.7862e-05 88444000.0 2525.2 3279.8 2757.9 2894.5 3049.9 2554.8999999999996 3062.8 2573.7 1302.3 2240.2 True False 2584.0322468161407 2895.799491262348 2383.3923280603194 2389.029911494279 2774.0370835035797 2529.200025663595 2831.770530125574 2505.437115444193 2209.9079837713084 2527.7514913958635 1.0222651457676317 1.1456029206665577 0.9428902865543057 0.945120562534025 1.0974326760150435 1.0005730524826757 1.1202725187838092 0.9911722429884323 0.8742584036815119 1.0 11.303638920742861 -8.002939330721684 24.969752846255275 0.9356578932940035 1.0380548512032837 0.2544372909915752 0.07007791279387823 145.40439651564898 1235207.5991583774 0.039243240385393875 0.018283483440361983 9.932547926258677e-09 8.002939330721684 0.10239695790928016 ASGS(ph)ENEGDYNPGR ddPTM_A459_Selumetinib_30min_R2 2 ASGSENEGDYNPGR 14 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 AS(0.227)GS(0.773)ENEGDYNPGR;AS(0.177)GS(0.823)ENEGDYNPGR 156.29 0.00032196 68400400.0 16655.2 13818.5 18011.6 17111.3 19184.0 15021.5 15627.6 19915.5 18639.5 15041.3 True False 15729.570660048194 14878.334516519362 16852.753265547315 14780.711421361058 16773.934412863997 17090.575273399703 16354.314365501938 19973.45080781149 22367.920831144493 14607.018587009255 1.0768501844748304 1.018574353684427 1.1537435353532925 1.0118910531479899 1.1483475777720915 1.1700248871182513 1.11962028856776 1.3673872384591108 1.5313132312323743 1.0 13.834374121779222 -7.7312234955355 7.103760600970344 1.337196956324659 1.0992908412681006 0.30931586890526874 0.1332934495325636 0.17293017386162315 29.112634289849716 0.06172361764637304 0.03441196829494225 1.8568486423891554e-08 7.7312234955355 -0.23790611505655845 ASGS(ph)ENEGDYNPGRK ddPTM_A459_Selumetinib_30min_R1 2 ASGSENEGDYNPGRK 15 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 ASGS(1)ENEGDYNPGRK;ASGS(1)ENEGDYNPGRK 197.73 3.7196e-05 32337000.0 4909.2 5560.200000000001 6873.0 7313.1 6738.1 5010.9 5958.2 5526.0 3140.3999999999996 4102.8 True False 5023.574808359654 4909.209199133147 5939.684350686601 6036.004368888858 6128.640044708178 4960.494895533175 5508.768177025659 5379.432529022273 5329.029434258935 4629.434344656262 1.085137931410205 1.0604339177635878 1.2830259397765853 1.3038319413377566 1.3238420913739588 1.071512095480748 1.1899441199299885 1.1620064415065594 1.151118913784837 1.0 12.176620210758058 -9.08590882077596 0.7328538553874601 0.9974406462370031 1.1954598474945235 0.2763174580676907 0.09022964075451789 2.835673062004076 2.375563466687559 0.1147473444626299 0.035833342525308634 8.205237935129581e-10 9.08590882077596 0.19801920125752037 ASGSLS(ph)PPILAPLSPGAEISPHDLSLESCR ddPTM_A459_Selumetinib_30min_R2 1 ASGSLSPPILAPLSPGAEISPHDLSLESCR 30 0 Q9NRF2-2;Q9NRF2-3;Q9NRF2 Q9NRF2-2 SH2B1 SH2B adapter protein 1 1 AS(0.091)GS(0.091)LS(0.794)PPILAPLS(0.023)PGAEISPHDLSLESCR 97.734 4.8771000000000014e-08 4081600.0 7798.3 7121.7 11590.0 14069.0 13911.0 6613.6 7709.8 10909.0 10574.0 12219.0 True False 7364.901705068316 7667.9114901252615 10844.31201823787 12152.777929621288 12163.3758140821 7524.563367716693 8068.32097667888 10940.743383917828 12689.09546224533 11866.205721225304 0.6206618929498735 0.6461974172931727 0.9138820169652415 1.024150281490855 1.0250433963339471 0.63411705009103 0.6799411004856357 0.9220085713117139 1.069347334805439 1.0 13.534571079293704 -5.249932071920448 9.218939185948438 0.8961356470011012 0.6329222343678513 0.3862490721869245 0.1380202691874313 0.26594838924714864 184.27387796353383 0.03920495565404561 0.09678770662457685 5.62429287979099e-06 5.249932071920448 -0.2632134126332498 ASGSLSPPILAPLS(ph)PGAEISPHDLSLESCR ddPTM_A459_Selumetinib_30min_R2 1 ASGSLSPPILAPLSPGAEISPHDLSLESCR 30 0 Q9NRF2-2;Q9NRF2-3;Q9NRF2 Q9NRF2-2 SH2B1 SH2B adapter protein 1 1 AS(0.006)GS(0.002)LS(0.005)PPILAPLS(0.986)PGAEISPHDLSLESCR 114.85 1.1427e-15 5077600.0 20779.0 15868.0 24510.0 28351.0 33918.0 19307.0 18618.0 22066.0 21373.0 26297.0 True False 19624.18636492756 17085.02457633819 22933.05328447027 24489.5448917971 29656.917609232754 21966.36399850401 19483.773890867116 22130.208406777052 25648.19721151591 25537.737282188547 0.7684387284622342 0.6690108989512648 0.8980064690564841 0.958955158054566 1.1612977798905135 0.8601531042385884 0.7629404937318466 0.8665688804862091 1.0043253608613323 1.0 14.640343083275308 -5.361864479656187 4.820937757562757 0.9364105242744664 0.7198587540131335 0.4259634852838824 0.10292417250537457 0.22169423794975418 8.163967972755223 0.029788561845461428 0.06493120427751127 4.346458329942095e-06 5.361864479656187 -0.21655177026133288 ASIANSDGPTAGS(ph)QTPPFK ddPTM_A459_Selumetinib_30min_R2 3 ASIANSDGPTAGSQTPPFK 19 0 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;H9KVA6 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 ASIANS(0.002)DGPT(0.114)AGS(0.714)QT(0.17)PPFK;ASIANS(0.016)DGPT(0.012)AGS(0.784)QT(0.189)PPFK;ASIANSDGPT(0.003)AGS(0.498)QT(0.498)PPFK 176.39 8.6836e-13 20812400.0 116675.0 103498.0 120041.0 116780.0 125113.0 94750.0 93178.0 108360.0 86814.0 108061.0 True False 110190.67058703132 111435.96380147805 112317.69275075862 100874.36254326359 109395.18641558883 107800.9524451367 97510.96162870417 108675.30966003622 104179.22578583016 104940.99815380375 1.0500249904763963 1.061891593961734 1.0702937338764724 0.9612483616309804 1.0424446912088345 1.027252973972492 0.9291979621328743 1.0355848674200656 0.9927409460422978 1.0 16.67921889189242 -5.743184911052237 24.98051051773349 0.9999954096208673 1.0608522800736906 0.43512277973950253 0.03253493849885268 234.32837100887681 320666.5576411011 0.008749068378525493 0.015115347666760084 1.8064048430620755e-06 5.743184911052237 0.060856870452823286 ASIANSDGPTAGSQT(ph)PPFK ddPTM_A459_Selumetinib_30min_R1 2 ASIANSDGPTAGSQTPPFK 19 0 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;H9KVA6 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 ASIANS(0.14)DGPT(0.013)AGS(0.025)QT(0.822)PPFK;ASIANSDGPTAGS(0.004)QT(0.996)PPFK 255.24 1.4953999999999994e-94 6186500.0 6403.5 7661.4 6458.9 6896.9 6515.799999999999 6195.0 6844.8 6335.0 3375.5 6033.799999999999 True False 6552.689090958008 6764.3997263117735 5581.816856198122 5692.485885847255 5926.447040457921 6132.683924609954 6328.491225219903 6166.9752210199185 5727.976963234311 6808.2970041890785 0.9624564097198173 0.9935523850016685 0.8198550757647154 0.8361100995365984 0.8704742223806388 0.900766215227769 0.9295263149251632 0.905802907426841 0.8413230150961309 1.0 12.733078258983914 -9.99346068785513 15.340097075741902 0.9999946946351032 0.8951691973209648 0.2582645225156708 0.05310469055864235 0.0 0.0 0.05537319065948121 0.013429971406853314 1.0151712552678504e-10 9.99346068785513 -0.10482549731413837 ASIANSDGPTAGSQT(ph)PPFK ddPTM_A459_Selumetinib_30min_R2 1 ASIANSDGPTAGSQTPPFK 19 0 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;H9KVA6 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 ASIANS(0.004)DGPT(0.037)AGS(0.098)QT(0.862)PPFK 105.01 0.002062 9667000.0 46017.0 41196.0 46486.0 43627.0 50054.0 33754.0 39042.0 37595.0 31748.0 37749.0 True False 43459.55936064639 44355.60073398207 43495.1413701299 37684.927339227244 43765.769031562464 38403.30711169549 40857.53036025536 37704.3952258127 38098.48711323667 36659.08828631919 1.185505733836405 1.2099482776972157 1.1864763528874194 1.0279832123727661 1.1938586330826841 1.0475794381942451 1.114526636373087 1.0285142644936867 1.0392644469408328 1.0 15.161883285962928 -4.768414145839316 0.21222314765376912 0.9826000357925463 1.4060923427455516 0.6042437624231379 0.04974143812305539 8.750667888048179 0.35975027311299657 0.09545290270755649 0.9932561109404346 1.704456234018005e-05 4.768414145839316 0.4234923069530053 ASIANSDGPTAGSQT(ph)PPFKR ddPTM_A459_Selumetinib_30min_R2 4 ASIANSDGPTAGSQTPPFKR 20 1 J3KP75;O75167-5;O75167-2;O75167;O75167-4;F6TH74;H9KVA6 J3KP75 PHACTR2 Phosphatase and actin regulator;Phosphatase and actin regulator 2 1 ASIANSDGPT(0.001)AGS(0.162)QT(0.837)PPFKR;ASIANSDGPTAGS(0.059)QT(0.941)PPFKR;ASIANSDGPTAGS(0.021)QT(0.979)PPFKR;ASIANSDGPT(0.014)AGS(0.051)QT(0.936)PPFKR 102.72 0.00077958 52861900.0 128074.0 119324.0 135949.0 146071.0 140185.0 101140.0 104216.0 110383.0 86852.0 121191.0 True False 120956.15980084366 128475.76711286705 127202.18935007963 126175.87781347042 122573.70703019908 115071.11694249211 109062.2505000864 110704.19625511058 104224.82684763867 117691.900937967 1.0277356286784525 1.0916279377676463 1.0808066514035262 1.0720863271634566 1.0414795415260152 0.9777318237313861 0.9266759193359524 0.9406271406344308 0.885573484810764 1.0 16.844655518019117 -6.819644159905424 2.0092401223358833 0.9328122236461481 1.07061072904562 0.7916960055577885 0.03058442509819259 0.13082629028499182 1.085849908350075 0.011981872079775165 0.010569999701611451 1.5148018962137167e-07 6.819644159905424 0.1377985053994718 ASIDSS(ph)LENLSTASSR ddPTM_A459_Selumetinib_30min_R1 1 ASIDSSLENLSTASSR 16 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 ASIDS(0.053)S(0.937)LENLS(0.007)T(0.003)ASSR 169.15 1.1845e-05 7847900.0 2557.5 2769.8 2924.6 3068.2 2538.2 2558.5 2458.9 2373.6 1545.7 1929.3 True False 2617.084773971282 2445.5105283549137 2527.4553836778746 2532.3964672471047 2308.6202581556076 2532.763812932132 2273.4231933282535 2310.644417460597 2622.94000653867 2176.9444479734143 1.2021826172034882 1.1233683664420173 1.16101050995158 1.1632802433725822 1.0604865274834065 1.1634489870836904 1.044318423212248 1.0614163441844593 1.2048722736036956 1.0 11.08808887746343 -14.522878740691475 0.019111089385738186 4.912653241300887e-06 1.9177984242007995 0.36198888275055063 0.05446127820873664 3940.2736618403314 5.681949403234292 379.5741482196185 212.86229404026054 3.000000031698741e-15 14.522878740691475 1.9177935115475582 ASIDSS(ph)LENLSTASSR ddPTM_A459_Selumetinib_30min_R2 2 ASIDSSLENLSTASSR 16 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 AS(0.004)IDS(0.305)S(0.692)LENLSTASSR;ASIDS(0.028)S(0.849)LENLS(0.007)T(0.007)AS(0.008)S(0.1)R 166.9 1.564e-05 6404200.0 29746.0 25672.0 31163.0 28224.0 31349.0 24752.0 24893.0 22050.0 26621.0 28455.0 True False 28092.83640267266 27640.95985150956 29158.006507708968 24379.842510884326 27410.658356384156 28161.363323715308 26050.573824543713 22114.161849425986 31945.943852887543 27633.430215031185 1.0166250148485576 1.0002724828738156 1.0551714456299561 0.8822590001013674 0.9919383204722136 1.0191048706069417 0.9427195111801039 0.8002684312929418 1.15606146628552 1.0 14.754127038589127 -5.720189083916414 24.999945538348335 0.9637949040756574 1.0216479021929958 0.06886053076019849 0.08807251527827491 397.51890721350037 240915.29523680636 0.023049163511001076 0.03992178014153573 1.9046312956030037e-06 5.720189083916414 0.05785299811733846 ASIGQS(ph)PGLPSTTFK ddPTM_A459_Selumetinib_30min_R1 2 ASIGQSPGLPSTTFK 15 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 ASIGQS(0.73)PGLPS(0.252)T(0.017)TFK;ASIGQS(0.996)PGLPS(0.003)T(0.001)T(0.001)FK 208.85 1.5275e-06 116750000.0 7440.5 9313.3 8469.0 9711.3 9110.400000000001 7617.6 9167.3 8019.0 4248.8 7127.700000000001 True False 7613.8491733072615 8222.894506364299 7318.956316887066 8015.403758678317 8286.365928571757 7540.973860227411 8475.803180364423 7806.31007061701 7209.90327992592 8042.609724677397 0.946688877609645 1.0224162041748375 0.9100225632520845 0.9966172713919459 1.0303080980227644 0.937627725126236 1.0538622997405735 0.9706190326088631 0.8964631539689839 1.0 12.973447998246735 -4.445738565633532 13.720984040422515 0.9800589487492503 0.5649941799878403 0.0390485749066366 0.049214577250746086 12721299.76034619 57256316.9344226 0.01189724655380547 149528725.06551144 3.583120670560032e-05 4.445738565633532 -0.41506476876140996 ASIGQS(ph)PGLPSTTFK ddPTM_A459_Selumetinib_30min_R2 2 ASIGQSPGLPSTTFK 15 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 ASIGQS(0.838)PGLPS(0.115)T(0.036)T(0.011)FK;ASIGQS(0.984)PGLPS(0.013)T(0.001)T(0.002)FK 234.82 1.6062e-14 76068000.0 176722.0 169483.0 195467.0 204176.0 213532.0 146423.0 150639.0 165853.0 132682.0 166730.0 True False 166900.4987142177 182481.80112626177 182890.86602837802 176366.87657675473 186706.2011596994 166591.43915434578 157644.01198551577 166335.60477155788 159222.10744483038 161916.07168343553 1.0307840165522748 1.1270147504753858 1.1295411513314788 1.0892487369726471 1.1531048105263537 1.028875252606493 0.973615591994647 1.027295209438894 0.9833619713559247 1.0 17.30488666815149 -6.924422458444261 5.765616856021346 0.9986547502961346 1.1070735160409484 0.7159563018663037 0.03300544032115817 0.10750519388745718 6.13356667991526 0.011420008739876971 0.010028991901327814 1.1900837949293634e-07 6.924422458444261 0.1084187657448138 ASIHEAWTDGK ddPTM_A459_Selumetinib_30min_R1 2 ASIHEAWTDGK 11 0 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75 O43707;P12814-4 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 ; 103.21 0.018986000000000003 42997000.0 14552.400000000001 15212.5 14204.3 14830.2 20868.7 14277.2 18886.6 15148.3 7078.6 10783.7 False True 14891.442605958828 13431.413427900614 12275.434078634904 12240.383967331996 18981.12976966824 14133.584330660407 17461.96855631111 14746.51787538691 12011.867199511305 12167.892937133114 1.2238308376723284 1.1038405332209635 1.0088381071445496 1.0059575664063956 1.5599356328771576 1.1615473939229475 1.4350856509447014 1.211920416425142 0.9871772591665677 1.0 13.57079174379397 -4.419761936366243 19.32563990702922 1.1804077231712342 5.4961914182106115 0.0022016431109719292 0.18597513998695592 1703.0853103713775 320507.9035388843 0.0460731114863566 1341.5505738470886 3.803978587449546e-05 4.419761936366243 4.315783695039377 ASIHEAWTDGK ddPTM_A459_Selumetinib_30min_R2 2 ASIHEAWTDGK 11 0 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75 O43707;P12814-4 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 ; 102.05 0.02061 22905700.0 185843.0 147277.0 213657.0 264283.0 280744.0 179910.0 158794.0 166663.0 167061.0 222651.0 False True 175514.59004847347 158572.6723298062 199910.5412321527 228287.1994863956 245474.4288367959 204690.9694396261 166178.23564434177 167147.96173745493 200477.86807434933 216222.48711322772 0.8117314364095857 0.7333773394566845 0.9245594382949954 1.0557976764315455 1.135286306776455 0.9466682775341355 0.7685520496178567 0.7730369027247648 0.9271832488420434 1.0 17.722157045426556 -5.299822456990789 7.986774580724589 0.9385380791251461 0.7726570885009935 0.28204193988774284 0.10768841935149627 0.3928529375894305 75.5199308954788 0.03285524467719144 0.06968214599535313 5.013921648068164e-06 5.299822456990789 -0.16588099062415262 ASIQECILPDS(ph)PLYHNK ddPTM_A459_Selumetinib_30min_R2 1 ASIQECILPDSPLYHNK 17 0 Q9NXE4-3;Q9NXE4-6;Q9NXE4-2;Q9NXE4;Q9NXE4-4 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 ASIQECILPDS(1)PLYHNK 108.69 0.002133 0.0 9814.1 5636.5 8406.0 7909.2 4215.1 4870.1 13253.0 7444.0 8932.0 7808.8 True False 9268.67161095507 6068.801425795952 7865.167111760786 6831.953315868984 3685.561454527889 5540.912068633885 13869.29076032129 7465.660807579457 10718.649580932022 7583.339654301019 1.2222413914558325 0.8002808396369175 1.0371640293468753 0.9009161698294927 0.486007698789749 0.7306691142986406 1.8289159384355265 0.984481923257279 1.413447118230127 1.0 12.888617626674783 -7.212568433232077 24.99999723071361 1.3054196877795374 0.8525547510177454 0.36908778425955635 0.2840834498280267 405.27538987272163 207319.28576456703 0.10672137136269488 0.0826658478498062 6.129591985115082e-08 7.212568433232077 -0.45286493676179207 ASIS(ph)EPSDTDPEPR ddPTM_A459_Selumetinib_30min_R2 1 ASISEPSDTDPEPR 14 0 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 AS(0.227)IS(0.771)EPS(0.001)DT(0.001)DPEPR 149.82 0.00043275 3871400.0 10831.0 9797.4 11738.0 12371.0 10687.0 8501.6 8555.0 10457.0 8922.6 11036.0 True False 10229.056379928306 10548.829076393737 10982.789859368093 10686.048458834674 9344.403517007791 9672.618230159102 8952.8244514109 10487.428138750462 10707.369318274077 10717.36200502844 0.9544378901383542 0.9842747750280684 1.0247661555348337 0.9970782412519914 0.871893989642556 0.9025185699261479 0.8353571006755539 0.9785456657925619 0.9990676169425204 1.0 13.387662220922406 -6.231250445755423 24.433698051675407 0.9239285043636993 0.9921937405737079 0.22204656271304823 0.05291474219996515 756.5001014292699 612280.1584235645 0.01645308709300479 0.02123781691933468 5.871506611467623e-07 6.231250445755423 0.06826523621000857 ASISVHS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 ASISVHSPQK 10 0 O43572;E7EMD6;J3QR74 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 ASISVHS(1)PQK 75.89 0.038921 5230000.0 4367.3 4185.2 4468.4 4893.1 7724.9 4945.5 5862.0 5056.4 1531.7 2607.4 True False 4469.049592713503 3695.1948383533063 3861.615823164266 4038.611939862726 7026.184158941862 4895.752760154727 5419.824620476721 4922.2878464980495 2599.183029058213 2942.0851882267534 1.5190075428805236 1.2559781929973501 1.3125438510812564 1.372703943456127 2.3881647571111517 1.6640418094438263 1.8421712063828257 1.6730609522101565 0.8834492758602909 1.0 11.522623305168143 -6.0436913471148115 24.997068931144387 1.6496729662521399 1.3503161255703577 0.04240900035257722 0.4038732537112571 1063.8952632959272 608682.8820372537 0.11928703905722475 0.15400854378047574 9.042919252486375e-07 6.0436913471148115 -0.29935684068178214 ASISVHS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 1 ASISVHSPQK 10 0 O43572;E7EMD6;J3QR74 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 AS(0.003)IS(0.06)VHS(0.937)PQK 74.46 0.041263 11102000.0 66040.0 62281.0 107400.0 156670.0 177140.0 94940.0 99973.0 138150.0 107670.0 166410.0 True False 62369.761179066125 67057.75243502129 100490.00092827826 135331.27572917507 154886.08954830724 108017.12322048841 104621.94259274146 138551.99362803643 129207.00855115872 161605.3109148948 0.38593880873080666 0.414947702246837 0.6218236291825748 0.8374184917749624 0.958422026302551 0.6684008254986917 0.6473917348411765 0.8573480218171865 0.7995220442922337 1.0 17.302115085303 -5.456771863998451 2.5524788780283583 0.8094886912200601 0.39260365692202137 0.723298654867971 0.10473554417700133 0.1588096707632695 2.0085913985944766 0.03061836983696271 0.07557190556779877 3.493237679586387e-06 5.456771863998451 -0.4168850342980387 ASLAGS(ph)DGGGGGGSAR ddPTM_A459_Selumetinib_30min_R2 1 ASLAGSDGGGGGGSAR 16 0 A6NIX2 A6NIX2 WTIP Wilms tumor protein 1-interacting protein 1 ASLAGS(0.999)DGGGGGGSAR 110.6 0.0027679 4749000.0 13251.0 13805.0 19184.0 15191.0 18102.0 11730.0 11057.0 16797.0 14972.0 16525.0 True False 12514.562467955868 14863.799109928708 17949.722325959905 13121.959594063337 15827.864926066733 13345.70102566179 11571.172409029854 16845.876489106948 17966.818352632603 16047.880312893702 0.7798265081713638 0.92621572569845 1.1185104808850153 0.8176755645118111 0.9862900655702052 0.8316176819276974 0.7210405476250326 1.049725955120197 1.1195757945799936 1.0 13.970095130851549 -7.962425534354322 24.814891859159054 1.0680757799472675 0.8926643739058342 0.342728962272569 0.10941738094825824 168.32115071425326 111162.30266419736 0.06133808440512275 0.029465774739512365 1.090371435244703e-08 7.962425534354322 -0.17541140604143335 ASLAS(ph)LDSNPSTNEK ddPTM_A459_Selumetinib_30min_R1 4 ASLASLDSNPSTNEK 15 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 ASLAS(0.999)LDS(0.001)NPSTNEK;ASLAS(1)LDSNPSTNEK;ASLAS(0.962)LDS(0.037)NPSTNEK;AS(0.009)LAS(0.515)LDS(0.47)NPS(0.006)TNEK 217.79 3.0723e-09 39548500.0 11986.1 11606.0 12074.4 13064.8 10768.6 10993.0 9903.64 9537.6 5457.96 7643.84 True False 12265.352809109352 10247.164124516978 10434.762799931666 10783.277936669698 9794.582031350743 10882.420400845393 9156.600461333694 9284.631865509014 9261.759486373685 8625.001321306743 1.4220696730572875 1.1880768179365875 1.2098273856670823 1.2502349315624177 1.1356035398110293 1.2617297082566286 1.0616346734595525 1.076478891959443 1.0738270223210202 1.0 13.074308962453884 -1.522878745291529 0.144794210218465 0.9496355305667761 2.3495176210834883 0.7152936002397987 0.06315274905970607 40.19717102357523 0.386169302386325 0.24635511262446919 11.722765895503155 0.02999999999922693 1.522878745291529 1.3998820905167122 ASLAS(ph)LDSNPSTNEK ddPTM_A459_Selumetinib_30min_R2 1 ASLASLDSNPSTNEK 15 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 ASLAS(0.913)LDS(0.087)NPSTNEK 260.07 2.2797999999999998e-36 12480000.0 18944.0 14795.0 16908.0 19791.0 21352.0 17663.0 19009.0 18854.0 13167.0 16867.0 True False 17891.168318840533 15929.728926576972 15820.15768803847 17095.431658620735 18669.5708706981 20095.91792125014 19892.956165618918 18908.862018552267 15800.767916718765 16380.005884270997 1.0922565257452466 0.9725105741185108 0.9658212457194459 1.0436767715106092 1.139778031986281 1.226856575219388 1.2144657520984932 1.1543867659235472 0.9646374994218745 1.0 13.99964825479498 -6.144902760952274 3.8857327686525656 1.1346982220890947 1.0063961631143263 0.23027042691500466 0.08526845794470815 0.2990461490815787 7.935760387401545 0.02657891096454196 0.03517231809012951 7.163037735208493e-07 6.144902760952274 -0.12830205897476832 ASLASLDS(ph)NPSTNEK ddPTM_A459_Selumetinib_30min_R2 2 ASLASLDSNPSTNEK 15 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 ASLAS(0.158)LDS(0.839)NPS(0.001)T(0.002)NEK;ASLAS(0.059)LDS(0.673)NPS(0.031)T(0.237)NEK 232.62 4.2293e-14 22902000.0 39727.0 30833.0 43138.0 39193.0 45069.0 30767.0 39974.0 39090.0 24799.4 33389.0 True False 37519.13237978134 33197.791956279005 40362.54804510312 33854.8457883039 39407.02929802795 35004.874974981765 41832.870206978296 39203.745428302114 29759.97295313097 32424.972814959638 1.1571060550734356 1.023834072143395 1.2447982077098732 1.0440978927416271 1.2153296017521118 1.0795652836702414 1.2901435706887692 1.2090602404519215 0.9178102668878989 1.0 14.984817744473938 -8.263492772541714 24.983348838398744 0.9589051149086569 1.1563191148360512 0.4702465231857731 0.08450836927787947 158.7864861887889 1931860.467223315 0.06739691360131991 0.020699495232439774 5.451389677276534e-09 8.263492772541714 0.19741399992739428 ASLASLDSNPS(ph)TNEK ddPTM_A459_Selumetinib_30min_R2 1 ASLASLDSNPSTNEK 15 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 ASLAS(0.031)LDS(0.166)NPS(0.776)T(0.027)NEK 233.48 3.2054e-14 11217000.0 39225.0 34335.0 39769.0 43105.0 46769.0 31397.0 35609.0 34039.0 24398.0 33784.0 True False 37045.03153011612 36968.3840955742 37210.305837213265 37234.024639727475 40893.46009983508 35721.65175641118 37264.889057894885 34138.047854540215 29278.281737077883 32808.56813862638 1.129126738283407 1.126790536526047 1.134164273185839 1.13488721855834 1.2464262361907268 1.088790330790302 1.1358279611728 1.0405223327728406 0.8923974253727884 1.0 15.001785011370435 -7.942062601612002 2.891655044085804 0.9469663657381211 1.1438546505453644 0.7510204657152745 0.045440403825523744 0.12503029061998977 2.05037719350409 0.03166799263855432 0.012212265660433432 1.1427136058494132e-08 7.942062601612002 0.1968882848072433 ASLENS(ph)LREVEAR ddPTM_A459_Selumetinib_30min_R2 1 ASLENSLREVEAR 13 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 AS(0.022)LENS(0.978)LREVEAR 65.528 0.041601 3807600.0 19321.0 21244.0 20752.0 23769.0 27193.0 16085.0 13078.0 13803.0 10474.0 23866.0 True False 18247.21616809112 22873.346489773667 19416.838913069227 20531.621196187974 23776.772231495546 18300.56274490792 13686.152913565375 13843.164444790333 12569.092668011874 23176.926568685107 0.7873009440667325 0.9869016248547116 0.837765907206341 0.8858647040772323 1.0258811564610515 0.789602654634728 0.5905076703335229 0.5972821462658539 0.5423105876770681 1.0 14.500401646579958 -7.0232643943225765 5.317126717598634 0.6523935542118224 0.9055255547525582 0.37064661549610256 0.13421378151810537 0.16800193681353048 13.970093859221933 0.048033537458621364 0.038769960775844 9.478412509392598e-08 7.0232643943225765 0.2531320005407358 ASLENSLR ddPTM_A459_Selumetinib_30min_R2 1 ASLENSLR 8 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 0 141.52 0.031482 121330000.0 126100.0 108270.0 123720.0 134190.0 140060.0 111850.0 117970.0 110510.0 111740.0 129950.0 False True 119091.86681829563 116573.9608570794 115759.98989615083 115913.09050933833 122464.41064771317 127256.32222679224 123455.83875312026 110831.56580408452 134091.12227646064 126198.00584935202 0.9436905600589339 0.9237385335251552 0.9172885824704592 0.9185017602236026 0.9704147844768973 1.008386157691775 0.9782709157900229 0.8782354765287569 1.0625454924900395 1.0 16.94532958781606 -6.318496558816989 5.323294447201287 0.9784151070655641 0.9250396558013906 0.29012615026531763 0.043545286714186664 0.30267646397785797 18.562115375820866 0.013365317720985963 0.015369985585812714 4.802898858575761e-07 6.318496558816989 -0.053375451264173535 ASLGS(ph)LEGEAEAEAS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 ASLGS(1)LEGEAEAEAS(0.947)S(0.053)PK 183.6 1.1255e-08 23019000.0 2825.7 2499.4 2444.6 2371.2 1813.2 2211.9 1907.2 2297.4 1594.6 2034.1 True False 2891.533312144927 2206.7690860604653 2112.636747226606 1957.1144329366855 1649.1963801464601 2189.6502942445127 1763.33836850447 2236.465488993082 2705.9197350239774 2295.19654881186 1.2598194754352385 0.9614728146932905 0.9204600574710002 0.852700146290222 0.7185425496566685 0.9540142849108131 0.7682733617812759 0.9744113157327721 1.1789490257053297 1.0 11.164401988564572 -10.927617636472771 14.778514144131641 0.9999787763943724 0.9387001176135469 0.0 0.1575147352074645 5.343095329126951e-10 0.0 0.1567322216885228 0.038013147067338965 1.181360276521076e-11 10.927617636472771 -0.0612786587808255 ASLGS(ph)LEGEAEAEAS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 3 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 ASLGS(1)LEGEAEAEAS(0.699)S(0.301)PK;AS(0.344)LGS(0.656)LEGEAEAEAS(0.656)S(0.344)PK;AS(0.002)LGS(0.998)LEGEAEAEAS(0.902)S(0.098)PK 210.47 2.0761e-10 9880400.0 127862.0 118959.2 104211.0 107988.9 94644.0 85015.4 126265.0 109576.0 78318.5 97353.0 True False 120755.9419121405 128082.98812588386 97506.1777163576 93280.62552875685 82753.97459190484 96725.49965703738 132136.57268935093 109894.84801871672 93984.38840172709 94542.16593652882 1.2772707364585911 1.3547710363635288 1.0313512150950581 0.9866563200104923 0.8753128698940744 1.0230937560915871 1.3976469798466562 1.1623897858707295 0.9941002247063369 1.0 16.528670296394253 -5.261966717973168 24.989447865490853 1.066312609553265 1.3160209007774535 0.3725006794162623 0.1332458749392109 53.63905650625379 2541989.616121783 0.038624262270571315 0.08928061305044753 5.470578849038726e-06 5.261966717973168 0.24970829122418858 ASLGS(ph)LEGEAEAEASS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 AS(0.001)LGS(0.999)LEGEAEAEAS(0.012)S(0.988)PK;ASLGS(1)LEGEAEAEAS(0.109)S(0.891)PK 254.82 2.8054e-32 38723000.0 9675.0 10289.4 11028.4 9654.3 7826.299999999999 8500.9 7863.9 8528.5 6789.0 8917.9 True False 9900.408675727142 9084.712264587717 9530.803854664942 7968.357738655803 7118.412546845491 8415.38866419964 7270.719691737784 8302.296475527766 11520.437151058439 10062.599332702066 0.983881832952662 0.9028196357837333 0.9471512816465959 0.791878666256713 0.7074128971538823 0.8363036613065554 0.7225488615162231 0.8250647969800847 1.144876862344961 1.0 13.296715404375645 -8.25200810331051 24.732321492654133 1.0724384317718894 0.8353099881363274 0.5175433568174073 0.08983276210232327 424.60238563865664 1113474.0808939969 0.06732113609933285 0.02468000404227489 5.59747157320643e-09 8.25200810331051 -0.23712844363556196 ASLGS(ph)LEGEAEAEASS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 ASLGS(1)LEGEAEAEAS(0.011)S(0.989)PK;AS(0.065)LGS(0.935)LEGEAEAEAS(0.124)S(0.876)PK;AS(0.001)LGS(0.999)LEGEAEAEAS(0.239)S(0.761)PK 175.77 4.3877e-08 11564200.0 74617.0 67541.0 65552.0 61498.0 63316.0 47813.0 73281.0 58073.0 47495.1 63779.0 True False 70470.0858555176 72721.17752145547 61334.45568762118 53121.866310032696 55361.67802777819 54398.80674680025 76688.71170354671 58241.98281549733 56995.44712397275 61937.53455225707 1.1377605900031678 1.1741051374930038 0.9902631115527036 0.8576684024323483 0.8938308317885854 0.8782849872867259 1.2381621622159336 0.9403342131152834 0.9202085219566715 1.0 15.918526336665625 -5.312494561046866 5.149875704033318 0.9617265398311621 1.156493991414173 0.3621726769036102 0.10173953821894603 0.2118380675476367 12.828979253921505 0.02842767010056122 0.06305340229691088 4.869736238160709e-06 5.312494561046866 0.1947674515830109 ASLGS(ph)LEGEAEAEASS(ph)PKGK ddPTM_A459_Selumetinib_30min_R1 2 ASLGSLEGEAEAEASSPKGK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 AS(0.021)LGS(0.979)LEGEAEAEAS(0.307)S(0.693)PKGK;AS(0.006)LGS(0.994)LEGEAEAEAS(0.2)S(0.8)PKGK 129.66 0.00034775 61945000.0 8931.6 7924.5 29087.0 29158.0 14761.599999999999 13775.0 8761.0 8740.2 7358.8 5761.2 True False 9139.68890213173 6996.695855999896 25137.145163454265 24066.10266344797 13426.415886372153 13636.436006699283 8100.150716478436 8508.381503829254 12487.346134513018 6500.706138840219 1.4059532467594862 1.0762978215852972 3.8668330219182843 3.7020751514452503 2.0653780681074654 2.097685346092592 1.246041667393932 1.3088395817484562 1.9209214918828597 1.0 12.666380723983258 -6.984250378514439 2.3227066433539094 1.398561414409958 2.508474895540056 0.25437855198848636 0.8480220889459505 0.48358848144703903 5.252408490092211 0.3967714180900385 0.31700900534817367 1.0369304345720128e-07 6.984250378514439 1.109913481130098 ASLGS(ph)LEGEAEAEASSPK ddPTM_A459_Selumetinib_30min_R1 5 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGS(1)LEGEAEAEASSPK;ASLGS(1)LEGEAEAEASSPK;AS(0.056)LGS(0.944)LEGEAEAEASSPK;AS(0.237)LGS(0.763)LEGEAEAEASSPK;AS(0.006)LGS(0.994)LEGEAEAEASSPK 222.96 1.1689e-14 799104400.0 39270.9 36992.2 43920.5 43338.700000000004 36558.5 32602.100000000002 32558.899999999998 32403.0 19478.940000000002 25652.899999999998 True False 40185.83556213053 32661.136026792796 37956.337338037396 35770.409613154996 33251.7901299274 32274.15247433839 30102.95595967924 31543.56718022235 33054.33849451146 28945.6995954062 1.3883179927877156 1.128358840287842 1.3112945227988624 1.2357763022881612 1.1487644311490262 1.114989546822369 1.039980252004574 1.089749690666604 1.141942981393938 1.0 14.821061405372625 -6.449375941640938 1.6541639258941616 1.0764709514466664 1.2651799605433385 0.6236600143680993 0.06972498513063569 0.255894385575157 1.4074976719228094 0.02549579656365138 0.029574854452343206 3.55323603925301e-07 6.449375941640938 0.1887090090966721 ASLGS(ph)LEGEAEAEASSPK ddPTM_A459_Selumetinib_30min_R2 7 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 AS(0.001)LGS(0.999)LEGEAEAEASSPK;ASLGS(1)LEGEAEAEASSPK;AS(0.004)LGS(0.996)LEGEAEAEASSPK;AS(0.001)LGS(0.999)LEGEAEAEASSPK;AS(0.246)LGS(0.754)LEGEAEAEASSPK;AS(0.005)LGS(0.994)LEGEAEAEASSPK;AS(0.175)LGS(0.753)LEGEAEAEAS(0.056)S(0.016)PK 232.73 4.4431e-19 466212600.0 125591.8 126521.6 121146.0 136608.0 132914.0 109089.1 127542.0 124008.9 103658.0 121537.1 True False 118611.91053980979 136225.39988893553 113351.59825379153 118001.75473805555 116216.15505376394 124115.13331274696 133472.9557196786 124369.74536822143 124392.49644651299 118028.00813169092 1.0049471512513146 1.1541785890086418 0.9603788121825996 0.99977756640944 0.9846489565772779 1.0515735652698999 1.1308583261928375 1.0537307825228623 1.0539235425181523 1.0 16.848769727227214 -6.990299577016633 24.65346700433477 1.067978617816273 1.023117528991758 0.09006360922621037 0.056959100890925644 398.00903051606457 1011526.9162704641 0.020461565522865956 0.018020853282586433 1.0225873665641873e-07 6.990299577016633 -0.044861088824514894 ASLGSLEGEAEAEAS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.5)S(0.5)PK;ASLGSLEGEAEAEAS(0.577)S(0.423)PK 239.19 5.8010999999999995e-25 241310000.0 8966.9 10186.7 8895.0 8065.8 6681.2 8050.299999999999 7522.2 8658.2 5967.4 8115.6 True False 9175.811323449883 8994.03642833165 7687.107856737567 6657.259443817774 6076.886639661667 7969.321291087573 6954.79439784204 8428.556410202795 10126.241958348235 9157.316312638275 1.002019697712755 0.982169461146463 0.8394498556447557 0.7269880406588007 0.6636099957882617 0.8702682116690545 0.7594795418657242 0.9204177427583562 1.1058089087053504 1.0 13.16070914174758 -8.041769371384369 4.685453584745996 1.0470695379825048 0.8313421243997344 0.41916418402287414 0.10178281191173057 0.22240326051515494 11.087118515556321 0.07804633922292996 0.029470924821820343 9.083027490473091e-09 8.041769371384369 -0.21572741358277037 ASLGSLEGEAEAEAS(ph)SPKGK ddPTM_A459_Selumetinib_30min_R1 2 ASLGSLEGEAEAEASSPKGK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.559)S(0.441)PKGK;ASLGSLEGEAEAEAS(0.563)S(0.437)PKGK 119.38 0.00014012 65105000.0 2702.3999999999996 1909.2800000000002 6654.9 6738.3 3877.4 3110.4 1974.4099999999999 2318.67 1818.5 1695.28 True False 2765.3606620449646 1685.7406099998093 5751.2011327490545 5561.582398556535 3526.6898546105717 3079.11220001724 1825.478664093389 2257.171339498384 3085.8616820149923 1912.8857014255789 1.445648665774478 0.8812552724627041 3.006557646629367 2.9074305874165733 1.8436490230348341 1.6096686789610746 0.9543061891951778 1.1799823365380515 1.6131971082826604 1.0 10.901534957137077 -6.894603641835717 2.8283899640303796 1.2078569345827448 2.065454943802969 0.29109114796572977 0.6084141701687104 0.3892270479934202 6.28932048010568 0.26168078750313367 0.22513339711397332 1.2746658720956646e-07 6.894603641835717 0.8575980092202242 ASLGSLEGEAEAEAS(ph)SPKGK ddPTM_A459_Selumetinib_30min_R2 1 ASLGSLEGEAEAEASSPKGK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.575)S(0.425)PKGK 158.33 7.1435e-07 18808000.0 51455.0 102260.0 56002.0 69308.0 44867.0 26950.0 15508.0 15334.0 11018.0 66655.0 True False 48595.337090685156 110103.01318227548 52398.8922903673 59868.1308370313 39230.40634393082 30662.11787225792 16229.152728519033 15378.619401319653 13221.907868641858 64730.49695951171 0.7507332613417299 1.7009449695889687 0.80949312536782 0.9248829168495065 0.6060575491714371 0.47368889955281474 0.25071880320446494 0.23757919564465615 0.2042608737719414 1.0 15.982157959558789 -6.159032009156597 1.2015394221007492 0.3635073036407429 1.193991297684632 0.45768959383143637 0.3191617652435969 0.3632503666206835 1.0727858552004244 0.12070162054524854 0.19583479730782524 6.933746997783039e-07 6.159032009156597 0.8304839940438892 ASLGSLEGEAEAEASS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.026)S(0.974)PK;ASLGSLEGEAEAEAS(0.018)S(0.982)PK;ASLGSLEGEAEAEAS(0.004)S(0.996)PK 340.49 4.289599999999998e-163 1182010000.0 21742.5 23672.4 21694.3 20525.3 15633.800000000001 18092.399999999998 17158.8 18260.5 12709.9 18327.1 True False 22249.057946459667 20900.8244029998 18748.3332182599 16940.941662599234 14219.725550371571 17910.406882584834 15864.497901370867 17776.17222153659 21567.772005632283 20679.561806071404 1.075896005684582 1.0106995785985868 0.9066117258227152 0.8192118296058608 0.6876221886963165 0.8660921856345349 0.767158320381486 0.8596010103230334 1.042951113175914 1.0 14.335917995235878 -5.256445712224694 2.2754310875061847 0.8468991067279705 1.0671298000473743 0.3420008305589839 0.09788115924851468 0.3468384211785294 3.3419104195744977 0.027619182140818026 0.09957747425616571 5.540567979409929e-06 5.256445712224694 0.22023069331940381 ASLGSLEGEAEAEASS(ph)PK ddPTM_A459_Selumetinib_30min_R2 7 ASLGSLEGEAEAEASSPK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.011)S(0.989)PK;ASLGSLEGEAEAEAS(0.433)S(0.567)PK;ASLGSLEGEAEAEAS(0.336)S(0.664)PK;ASLGSLEGEAEAEAS(0.002)S(0.998)PK;ASLGSLEGEAEAEASS(1)PK;ASLGSLEGEAEAEAS(0.237)S(0.763)PK;ASLGSLEGEAEAEAS(0.311)S(0.689)PK 369.44 4.245299999999996e-230 476659400.0 470503.8 426628.9 393041.8 388007.4 338142.2 278924.9 424175.4 345640.2 260827.7 321138.3 True False 444355.0823719431 459349.9648018726 367753.91849955614 335160.1227699016 295661.7538063773 317344.273146855 443900.3965876096 346645.9557581848 313000.5281348475 311866.2028614924 1.4248260256956806 1.4729071652752364 1.179204143075692 1.0746920304113703 0.9480403810787028 1.0175654502959897 1.4233680742403398 1.1115213914735702 1.0036372177008834 1.0 18.2505676898419 -5.363100218991689 3.486641704411212 1.0946729441663832 1.4522595787945733 0.5699770261983396 0.12482840050654659 0.18501685806699927 4.142242099107213 0.03615742452597775 0.08603564068957295 4.334108517640005e-06 5.363100218991689 0.3575866346281902 ASLGSLEGEAEAEASS(ph)PKGK ddPTM_A459_Selumetinib_30min_R1 4 ASLGSLEGEAEAEASSPKGK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.194)S(0.806)PKGK;ASLGSLEGEAEAEAS(0.148)S(0.852)PKGK;ASLGSLEGEAEAEAS(0.045)S(0.955)PKGK;ASLGSLEGEAEAEAS(0.127)S(0.873)PKGK 173.03 4.9325e-10 471411000.0 9780.599999999999 7361.76 28040.7 27184.5 13271.5 12797.3 8100.499999999999 8531.8 7596.44 5692.45 True False 10008.468950265311 6499.841716810627 24232.92695653975 22437.237391264884 12071.095168273634 12668.570781018714 7489.47276325003 8305.508948807857 12890.603857974129 6423.131406658507 1.5581915294291007 1.0119428212339854 3.7727590208443824 3.4931929569439344 1.8793162406361783 1.9723356068795204 1.1660158089691433 1.2930622811481005 2.006903337616781 1.0 12.649061096566001 -6.841733897665803 2.2908146868538313 1.4109465648406596 2.4417655502313633 0.24386125672357128 0.8102716754160246 0.48798370888035636 5.239097339101712 0.3553721846649193 0.3115661744626437 1.4396804337617168e-07 6.841733897665803 1.0308189853907037 ASLGSLEGEAEAEASS(ph)PKGK ddPTM_A459_Selumetinib_30min_R2 3 ASLGSLEGEAEAEASSPKGK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ASLGSLEGEAEAEAS(0.225)S(0.775)PKGK;ASLGSLEGEAEAEAS(0.247)S(0.753)PKGK;ASLGSLEGEAEAEAS(0.165)S(0.835)PKGK 102.16 0.0003616 54679000.0 74917.0 134165.0 89980.0 103337.0 73067.0 33938.4 28142.899999999998 26150.7 16144.5 88641.0 True False 70753.41305651267 144455.02409153112 84190.78476281639 89262.32233373198 63887.67023273217 38613.10653787894 29451.60061409839 26226.794207518575 19373.851115019825 86081.70401302316 0.8219332303855009 1.6781152946237767 0.978033436118775 1.036948830848279 0.7421747857485106 0.44856345469226805 0.3421354276356182 0.30467326952020796 0.22506351770277208 1.0 16.39341901630558 -6.348011486290981 1.4257124251444604 0.40071820837610794 1.2187392842102753 0.5420420284905842 0.28662849145294306 0.27402992647226304 1.1240344176445622 0.10633985114711828 0.1370544355349669 4.487335215991371e-07 6.348011486290981 0.8180210758341674 ASLLHSMPTHS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 ASLLHSMPTHSSPR 14 0 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4X8;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 ASLLHSMPT(0.018)HS(0.491)S(0.491)PR 99.915 0.0061903 19314000.0 1860.5 1964.3 2415.4 2883.4 2747.8 1952.5 2240.4 1995.6 917.62 1416.7 True False 1903.846030097194 1734.3188428217052 2087.401946842487 2379.8683181214737 2499.2619751634916 1932.8596227281569 2071.404824243613 1942.6702053776414 1557.134119686882 1598.5472448265884 1.1909851499595339 1.0849343667724036 1.3058118573586044 1.488769459785121 1.5634583108205935 1.209135125022742 1.2958045693972093 1.2152723115721136 0.9740932742064818 1.0 10.642545668048452 -8.126364999564187 2.498542828236279 0.9780469701999551 1.3107959710457953 0.475260244944004 0.1315440909803182 0.2948242019373495 3.2988325641972005 0.12870245551501494 0.04026905354123148 7.475409711826323e-09 8.126364999564187 0.33274900084584014 ASLLHSMPTHS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 3 ASLLHSMPTHSSPR 14 0 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4X8;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 ASLLHSMPT(0.002)HS(0.499)S(0.499)PR;ASLLHSMPT(0.006)HS(0.497)S(0.497)PR;ASLLHSMPT(0.033)HS(0.726)S(0.241)PR 127.05 0.00082547 43481500.0 57926.0 52445.0 74715.0 108556.0 115765.0 67615.0 52910.0 71497.0 63190.0 91201.0 True False 54706.70481615062 56467.362862746195 69907.9182435412 93770.48553045485 101221.56574776897 76928.3525021416 55370.41983917603 71705.04443303449 75829.76567611896 88567.79016134437 0.6176817183367808 0.6375609322517738 0.7893153720578283 1.0587425220797844 1.1428710772095945 0.8685815956568506 0.6251755828874975 0.809606339984424 0.8561776864702112 1.0 16.43449450244644 -5.404482243314198 3.64257262127836 0.8984455661223401 0.6278798550095219 0.40254989045476675 0.13527794443030822 0.27672728780625516 6.534837922023953 0.04181522398558343 0.09508984040504781 3.940195373085504e-06 5.404482243314198 -0.27056571111281813 ASLLHSMPTHSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ASLLHSMPTHSSPR 14 0 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4X8;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 ASLLHSMPT(0.007)HS(0.163)S(0.83)PR 130.02 0.00066527 28208000.0 2278.5 2054.6 2300.4 3057.4 4786.3 2039.5 2365.8 1474.5 874.66 1268.4 True False 2331.58461681078 1814.0464768423735 1988.0183151927038 2523.482484505996 4353.380010089899 2018.9844817178378 2187.345801283493 1435.3914701489934 1484.2341373611391 1431.2114952622596 1.6290985815367094 1.2674901528162767 1.3890457991524259 1.7631793014935122 3.0417447208193167 1.4106821307691304 1.5283176585181613 1.0029205850432104 1.037047384173758 1.0 10.483021164707345 -7.577212384893769 2.1711553623416715 0.999348786732355 1.7691890581079484 0.3345551677207357 0.4649754760104849 0.41804451050375796 3.9259144102616417 0.30476985740062523 0.15197684003892994 2.647205247869668e-08 7.577212384893769 0.7698402713755933 ASLLT(ph)DEEDVDMALDQR ddPTM_A459_Selumetinib_30min_R1 3 ASLLTDEEDVDMALDQR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 AS(0.183)LLT(0.817)DEEDVDMALDQR;ASLLT(1)DEEDVDMALDQR;ASLLT(1)DEEDVDMALDQR 318.32 1.599799999999998e-222 4580700.0 1349.93 1741.8999999999999 1768.28 1304.9699999999998 1527.1 1585.37 1347.74 1427.94 540.0899999999999 1336.5700000000002 True False 1381.3807424934723 1537.9575382126588 1528.1572884667698 1077.0814868207592 1388.9740746314028 1569.4226172007882 1246.0788867283004 1390.0663925971885 916.4932833871188 1508.1317787942908 0.9159549330615178 1.0197766268423922 1.0132783553493507 0.7141826078897798 0.9209898592163138 1.040640240639646 0.826240056903055 0.9217141447072402 0.607701061852718 1.0 10.558546779785038 -7.701499676216954 2.22833713008808 0.8113625040431138 0.9316970741283486 0.098626469090622 0.12860659910155792 0.6664121861892717 6.593239073590421 0.08230099316774722 0.0369324843951732 1.9883842928122783e-08 7.701499676216954 0.12033457008523474 ASLLT(ph)DEEDVDMALDQR ddPTM_A459_Selumetinib_30min_R2 3 ASLLTDEEDVDMALDQR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 ASLLT(1)DEEDVDMALDQR;ASLLT(1)DEEDVDMALDQR;AS(0.087)LLT(0.913)DEEDVDMALDQR 132.15 0.0012181 2228790.0 6288.8 5391.98 5097.42 7180.099999999999 9371.019999999999 7299.299999999999 7484.57 5587.5 6362.24 10258.8 True False 5939.293672061044 5805.527528051672 4769.4575468512585 6202.157993636635 8193.74868961826 8304.712318551841 7832.617335394096 5603.758699939576 7634.865775838443 9962.601788436545 0.5961588948536216 0.5827320665160046 0.4787361422381754 0.6225440025953255 0.8224506874427754 0.8335887045280689 0.7862019883686716 0.5624794425130775 0.7663525992477314 1.0 13.28230684393307 -6.100114766660343 4.453584396441554 0.7738697645606835 0.5545582082564801 0.5244823803702248 0.10521763594730585 0.2027383971768146 6.742405950182716 0.032065774183399925 0.04259284596457929 7.941183532768153e-07 6.100114766660343 -0.2193115563042034 ASLPQAATFGELSGPLKPGS(ph)PYRPPVPR ddPTM_A459_Selumetinib_30min_R1 2 ASLPQAATFGELSGPLKPGSPYRPPVPR 28 2 Q14687-3;Q14687;H0Y613;Q14687-2 Q14687-3 GSE1 Genetic suppressor element 1 1 ASLPQAATFGELS(0.004)GPLKPGS(0.943)PY(0.053)RPPVPR;ASLPQAATFGELS(0.247)GPLKPGS(0.57)PY(0.183)RPPVPR 77.062 0.0001011 28586300.0 2601.77 2673.7299999999996 3159.82 3906.9300000000003 3172.36 2858.9500000000003 2261.83 2555.91 1573.0500000000002 2111.09 True False 2662.386178836859 2360.688448616646 2730.7337996488495 3224.6580176591256 2885.4205981256473 2830.1915587189083 2091.2183420902206 2488.1189640342577 2669.350958973705 2382.0689652579663 1.1176780427717532 0.9910243922601943 1.1463705877017396 1.3537215188519578 1.2113085893855178 1.1881232659493604 0.8778999989463999 1.044520121089276 1.12060187925106 1.0 11.217999467131685 -7.2266699437714665 24.922968262865822 1.0144654656821706 1.1694138542906785 0.36735200750839625 0.10106063742946339 732.3181047574312 524931.3346265933 0.04270736603350676 0.033079619618244106 5.9337610875348094e-08 7.2266699437714665 0.1549483886085079 ASLQSGQEGAGDS(ph)PGSQFSK ddPTM_A459_Selumetinib_30min_R2 1 ASLQSGQEGAGDSPGSQFSK 20 0 Q12778 Q12778 FOXO1 Forkhead box protein O1 1 ASLQSGQEGAGDS(0.998)PGS(0.002)QFSK 284.41 2.3481999999999995e-72 4149100.0 15273.0 14257.0 17553.0 16070.0 14085.0 12515.0 11250.0 10963.0 11905.0 12977.0 True False 14424.187802663186 15350.46605651964 16423.65909026139 13881.238277703756 12315.516378502376 14238.827650141282 11773.147291452085 10994.900514977644 14286.33265349258 12602.32029170478 1.144566037744463 1.2180666497282862 1.3032250181001928 1.101482739400045 0.9772419755597557 1.1298576230849886 0.9342047352344726 0.8724504901065571 1.1336271672841283 1.0 13.621401761302808 -5.98956387316425 4.652067340540841 1.0057325897827873 1.2211250129527096 0.5728242624284358 0.0827127852195238 0.13757458858428265 7.818565047254788 0.024464181189163013 0.035343207200379555 1.024321118846123e-06 5.98956387316425 0.21539242316992224 ASLS(ph)CSALGSSPVHR ddPTM_A459_Selumetinib_30min_R2 2 ASLSCSALGSSPVHR 15 0 O60269 O60269 GPRIN2 G protein-regulated inducer of neurite outgrowth 2 1 AS(0.173)LS(0.823)CS(0.003)ALGSSPVHR;AS(0.071)LS(0.912)CS(0.017)ALGSSPVHR 122.29 0.0010422 12641700.0 25216.0 20466.6 28615.0 37759.0 32185.0 22984.0 32390.0 23682.0 25482.0 31421.0 True False 23814.59566764584 22036.322409508655 26773.942053656316 32616.15906209185 28141.632562449337 26149.837372021375 33896.19917956741 23750.910699233853 30579.11202656851 30513.794088437702 0.7804534434041317 0.7221757591219594 0.8774373313281781 1.0688988385895537 0.9222593716430948 0.8569841330196981 1.1108483947072112 0.7783663555701045 1.0021406036214802 1.0 14.897173955475807 -5.449665016919212 4.541874530370344 0.9550576739494285 0.7555004789526345 0.4497960659492678 0.09251159432209759 0.19243924576419055 7.393541654073829 0.023720362582305414 0.05057233371130165 3.5508717197220644e-06 5.449665016919212 -0.19955719499679403 ASLS(ph)DLTDLEDIEGLTVR ddPTM_A459_Selumetinib_30min_R2 1 ASLSDLTDLEDIEGLTVR 18 0 J3KSI3;J3KSU7;K7EN88;Q8WZ73-3;Q8WZ73-2;Q8WZ73 J3KSI3 RFFL;hCG_2039718 E3 ubiquitin-protein ligase rififylin 1 AS(0.285)LS(0.706)DLT(0.008)DLEDIEGLTVR 108.96 0.0014823 27578000.0 28113.0 18645.0 24749.0 24483.0 22027.0 21497.0 34169.0 29586.0 28911.0 21419.0 True False 26550.5920052557 20075.011546875823 23156.676284673777 21148.373164469263 19259.771336121517 24458.01661966338 35757.92620458903 29672.09036177403 34694.0078408336 20800.577816754638 1.2764353105551467 0.9651179752663227 1.1132708181799318 1.0167204656898752 0.9259248231367873 1.1758335193920775 1.719083311992728 1.4265031780931339 1.6679348115458579 1.0 14.344335984924852 -7.066979388751897 6.317517393816709 1.4867099899801983 1.0541362868465671 0.4577134927683968 0.20157945841190755 0.18331087942003657 13.774784373143781 0.07191533128997298 0.05598045878603128 8.570785204854745e-08 7.066979388751897 -0.4325737031336312 ASLS(ph)LIEK ddPTM_A459_Selumetinib_30min_R2 1 ASLSLIEK 8 0 P52292 P52292 KPNA2 Importin subunit alpha-1 1 AS(0.002)LS(0.998)LIEK 83.86200000000002 0.037877 2222300.0 24973.0 20773.0 20229.0 22913.0 22373.0 24200.0 21143.0 19904.0 18939.0 20241.0 True False 23585.100634839782 22366.222304277377 18927.488163669892 19792.20987287034 19562.303722842273 27533.330334272418 22126.191394059697 19961.917344715428 22727.329199873686 19656.58973756619 1.1998571954608035 1.1378485588236469 0.9629080332025807 1.006899474278845 0.9952033381180192 1.4007175558867566 1.1256373404270523 1.0155330915090381 1.1562193393312232 1.0 14.262725426789261 ASLS(ph)PDASDFEHITAETPSRPLSSTSNPFK ddPTM_A459_Selumetinib_30min_R1 1 ASLSPDASDFEHITAETPSRPLSSTSNPFK 30 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 AS(0.129)LS(0.435)PDAS(0.433)DFEHIT(0.002)AETPSRPLSSTSNPFK 49.199 0.010247 49118000.0 1200.5 1365.0 1327.3 1773.8 1374.6 1401.7 1646.4 1265.2 659.28 1112.0 True False 1228.4693142336364 1205.1851654287157 1147.0599503370179 1464.0391283498193 1250.2676727053415 1387.6001706417712 1522.210722475755 1231.6427860512078 1118.7500080939465 1254.7360317972502 0.9790659414426873 0.9605089316694291 0.9141842756312656 1.1668104615221488 0.9964388054708938 1.1058901119259403 1.2131720807406647 0.9815951362192379 0.8916218070915514 1.0 10.293168170214376 -5.732110922592072 24.99997908339389 1.0568201449615227 0.9521786118714483 0.20233054070994838 0.09000629460691983 341.86432960666104 291407.357307447 0.025453817139674723 0.04407938980575109 1.8530582757506582e-06 5.732110922592072 -0.1046415330900744 ASLSPDAS(ph)DFEHITAETPSRPLSSTSNPFK ddPTM_A459_Selumetinib_30min_R1 1 ASLSPDASDFEHITAETPSRPLSSTSNPFK 30 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 AS(0.002)LS(0.028)PDAS(0.969)DFEHITAETPSRPLSSTSNPFK 88.50399999999998 6.891899999999999e-07 38894000.0 2060.5 2008.8 2636.4 2862.3 2536.9 1964.8 2124.0 1993.5 825.31 1838.5 True False 2108.5056409649387 1773.608762134216 2278.391360708593 2362.453037025417 2307.4378429260723 1945.0358958956635 1963.7849699577885 1940.6259041994015 1400.4907917425307 2074.489383506515 1.0163974121674828 0.8549615998209065 1.0982902003853217 1.138811823192923 1.1122919506224727 0.9375974210135335 0.9466353434108192 0.9354716006881444 0.6751014504471831 1.0 11.018540558694164 -7.468084826573434 1.5306144382902465 0.8492814165029531 1.0360309129759846 0.3113931812952734 0.10858274456200061 0.5029070760237171 2.27447745556598 0.07392654443766243 0.03700059684928246 3.4034170752891476e-08 7.468084826573434 0.18674949647303152 ASLSPDASDFEHITAETPS(ph)RPLSSTSNPFK ddPTM_A459_Selumetinib_30min_R1 1 ASLSPDASDFEHITAETPSRPLSSTSNPFK 30 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 ASLSPDASDFEHIT(0.066)AET(0.118)PS(0.367)RPLS(0.367)S(0.027)T(0.027)S(0.027)NPFK 88.244 9.2169e-07 22022000.0 1302.5 1333.4 1445.6 1433.3 1529.7 1202.5 1384.6 1088.9 397.86 952.54 True False 1332.8457157761864 1177.2849081191578 1249.295460112404 1183.0010613732074 1391.3389050904702 1190.4039417826418 1280.1585072521443 1060.0188347543158 675.1393614553116 1074.8077875253175 1.2400782086302018 1.095344601875083 1.1623431413618934 1.100662904664097 1.294500208538633 1.1075505365694063 1.1910580869530494 0.9862403743788901 0.6281489297819294 1.0 10.069862964217965 -7.975381810489077 4.276094020804173 0.807916652057823 1.1650324626249393 0.6601865236443518 0.10288895105912539 0.10676206654285723 4.509387507654008 0.06015962018203059 0.025197750485896977 1.0583228902889534e-08 7.975381810489077 0.3571158105671163 ASLSPDASDFEHITAETPSRPLS(ph)STSNPFK ddPTM_A459_Selumetinib_30min_R2 1 ASLSPDASDFEHITAETPSRPLSSTSNPFK 30 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 ASLSPDAS(0.003)DFEHIT(0.01)AET(0.032)PS(0.108)RPLS(0.212)S(0.212)T(0.212)S(0.212)NPFK 59.628 0.0012728 4410400.0 12735.0 11932.0 13338.0 15587.0 15770.0 10384.0 12734.0 10930.0 12840.0 15735.0 True False 12027.2396822442 12847.146032572935 12479.84760131637 13464.023710925234 13788.831614411241 11814.301743433254 13326.156231942312 10961.804490441094 15408.35877957538 15280.689665560205 0.7870874905176127 0.8407438612884065 0.816707090743659 0.8811136150006768 0.902369717349124 0.7731523905010953 0.8720912814541976 0.7173632035173737 1.0083549314075082 1.0 13.899422037754919 -8.28652582963511 24.533066218974763 1.0041775988616268 0.8286021316716911 0.6527614799117789 0.05252283228280144 418.1271495287052 408898.5247215424 0.04881889426426789 0.012627068393620594 5.169805096732356e-09 8.28652582963511 -0.17557546718993577 ASLTGS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 ASLTGSPSR 9 0 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 ASLT(0.007)GS(0.992)PSR;ASLT(0.004)GS(0.995)PS(0.001)R 131.09 0.0036874 27499000.0 123699.0 140559.0 136516.0 123124.0 139855.0 120600.0 87608.0 101070.0 91154.0 129560.0 True False 116824.30478633096 151339.4233315807 127732.70918738209 106354.29879925313 122285.16458043658 137211.5553022005 91681.94559195876 101364.09696696086 109387.34705556202 125819.26616269344 0.9285088710918776 1.2028318710418153 1.0152078698520974 0.8452942227602035 0.9719112844157983 1.0905448703283327 0.7286797037379582 0.8056325557954672 0.8694006124158778 1.0 16.940993327251682 -6.163492600884948 0.7239305621127028 0.8616687905231452 1.0712770224525503 0.19743302456362388 0.11968339441620819 1.1709128916245342 1.282474628773352 0.07216910352831558 0.1473021668740268 6.862895706904404e-07 6.163492600884948 0.20960823192940514 ASLVALPEQT(ph)ASEEETPPPLLTK ddPTM_A459_Selumetinib_30min_R2 1 ASLVALPEQTASEEETPPPLLTK 23 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AS(0.002)LVALPEQT(0.573)AS(0.424)EEET(0.001)PPPLLTK 76.967 0.0086406 0.0 25874.0 21931.0 28183.0 27414.0 29159.0 19982.0 23171.0 20361.0 20314.0 24567.0 True False 24436.02666182855 23613.037180720487 26369.736463330297 23680.165908212246 25495.785735232555 22734.33912146409 24248.49741246547 20420.247139055 24377.367620583645 23857.686877268367 1.024241234598113 0.9897454561372007 1.10529309060785 0.99255917097205 1.0686612606826091 0.9529146408206656 1.0163809063807216 0.8559189851096352 1.021782528456706 1.0 14.542166552822973 -6.773188844678916 24.951623192712365 0.9633306786330174 1.0349499096412953 0.27198117986465387 0.054093500222324196 271.0676609730026 575646.1781701173 0.018053103458604367 0.016054209393423738 1.685819819368912e-07 6.773188844678916 0.07161923100827794 ASLVALPEQTAS(ph)EEETPPPLLTK ddPTM_A459_Selumetinib_30min_R1 2 ASLVALPEQTASEEETPPPLLTK 23 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 ASLVALPEQT(0.022)AS(0.97)EEET(0.008)PPPLLTK;ASLVALPEQT(0.328)AS(0.672)EEETPPPLLTK 121.02 6.993099999999998e-06 33989000.0 7881.900000000001 9390.9 9572.5 10715.5 9925.8 8392.7 9784.0 8501.6 5084.700000000001 7745.099999999999 True False 8065.532934492372 8291.409062289029 8272.607077978682 8844.239079846933 9028.013142542317 8308.277057961903 9045.985002856412 8276.10995091128 8628.364528205459 8739.259028662671 0.9229080987346137 0.948754240501992 0.9466028013183403 1.0120124659127225 1.0330410293289856 0.9506843807595986 1.0350974805973543 0.9470036216763488 0.9873107662682266 1.0 13.09329524848513 -5.674229397191191 6.032767823146033 0.9941300772178076 0.9390198068268869 0.4465548863465416 0.028425032652226005 0.1969850878050411 10.850114281671981 0.007671880577801415 0.01337539506266466 2.1172424984772904e-06 5.674229397191191 -0.055110270390920646 ASLVALPEQTASEEET(ph)PPPLLTK ddPTM_A459_Selumetinib_30min_R2 1 ASLVALPEQTASEEETPPPLLTK 23 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 AS(0.001)LVALPEQT(0.171)AS(0.362)EEET(0.466)PPPLLTK 67.979 0.029031 0.0 4602.4 4081.3 4353.9 5292.6 5405.7 3850.4 4849.0 5205.3 3583.5 3780.1 True False 4346.617032866961 4394.322586552119 4073.774814167893 4571.738749755753 4726.587638428841 4380.757649548861 5074.488108111217 5220.446561216199 4300.3001313557925 3670.9586911206943 1.1840550108560328 1.197050404620759 1.1097304973824764 1.2453800585699488 1.2875621972705658 1.1933552017746827 1.3823332091383584 1.422093518470639 1.1714378976144155 1.0 11.841941164708201 -5.92162491516131 6.961094202560492 1.268243546250476 1.1674582858113494 0.0678065066164163 0.11335666886182104 0.438950656870311 32.216438939930356 0.031246485033966785 0.04659075997704815 1.197774560391779e-06 5.92162491516131 -0.10078526043912661 ASLVS(ph)EEEEDEEEDKATPR ddPTM_A459_Selumetinib_30min_R1 2 ASLVSEEEEDEEEDKATPR 19 1 Q96GN5-5;Q96GN5-2;Q96GN5;C9J8L0;C9IZR6;Q96GN5-4 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 AS(0.008)LVS(0.992)EEEEDEEEDKATPR;AS(0.009)LVS(0.991)EEEEDEEEDKATPR 183.6 1.0155e-13 23341000.0 3730.0 3615.1200000000003 3707.8500000000004 3848.8 3620.65 2916.48 3777.9 3763.1 2489.12 4251.7 True False 3816.9017426834357 3191.860069776307 3204.3443357621604 3176.6793309238838 3293.162846777675 2887.1428591519675 3492.9299613952617 3663.290363728502 4223.854841868106 4797.447110065084 0.7956110104216769 0.6653247021899955 0.6679269749612078 0.6621603653032847 0.68644067797404 0.6018081685767244 0.7280809733299749 0.7635916102217966 0.8804380215065681 1.0 12.228051186034817 -8.32101373344512 1.355321583577864 0.9975621673951072 0.678589232694656 0.832742235093406 0.046566322863747685 0.15177395063060928 0.5640668978398373 0.043783826772759195 0.013575331982863413 4.77514173262324e-09 8.32101373344512 -0.3189729347004512 ASLVS(ph)EEEEDEEEDKATPR ddPTM_A459_Selumetinib_30min_R2 3 ASLVSEEEEDEEEDKATPR 19 1 Q96GN5-5;Q96GN5-2;Q96GN5;C9J8L0;C9IZR6;Q96GN5-4 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 AS(0.018)LVS(0.982)EEEEDEEEDKATPR;AS(0.004)LVS(0.996)EEEEDEEEDKATPR;AS(0.014)LVS(0.986)EEEEDEEEDKATPR 137.86 8.525799999999999e-05 33959000.0 83047.0 66287.3 82827.5 84354.2 85252.6 61568.0 93256.5 85353.3 59864.3 68312.8 True False 78431.5802034813 71371.32276273645 77498.46882576321 72865.01244088855 74542.40622008602 70048.43314134238 97593.11203424905 85601.66397200064 71838.83274829706 66340.43196602995 1.182259112265695 1.0758344594331644 1.1681936117848435 1.0983499847905656 1.1236346223711047 1.0558935337836077 1.471095516595705 1.2903392612190636 1.0828815945166381 1.0 16.01760078560394 ASMSEFLES(ph)EDGEVEQQR ddPTM_A459_Selumetinib_30min_R1 5 ASMSEFLESEDGEVEQQR 18 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 1 ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR 339.81 4.6992999999999975e-163 64331000.0 8899.22 11242.3 10772.19 11696.23 10724.02 10003.519999999999 10170.55 8808.77 4858.1 8211.12 True False 9106.554511132239 9926.046289596523 9309.385765404148 9653.702995929085 9754.034284479509 9902.893671269432 9403.377225143218 8575.132804682498 8243.84087841464 9265.097235081876 0.9828881748429664 1.0713375194824717 1.00478014738524 1.041942977066206 1.052771928560695 1.0688386122676155 1.0149248288013375 0.9255307944543898 0.8897738112450353 1.0 13.177590401749416 -7.686934265648015 4.363364996784062 0.9303291309510316 1.038241853014943 0.595759772521677 0.03614957596873481 0.12713949875481584 4.570428610193647 0.017559848036575225 0.009458239452310847 2.0562017969543374e-08 7.686934265648015 0.10791272206391145 ASMSEFLES(ph)EDGEVEQQR ddPTM_A459_Selumetinib_30min_R2 5 ASMSEFLESEDGEVEQQR 18 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 1 ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR;ASMSEFLES(1)EDGEVEQQR;ASMS(0.001)EFLES(0.999)EDGEVEQQR 284.24 2.1796999999999994e-67 18847800.0 85922.3 75035.2 78211.9 90688.9 98787.0 65873.4 63928.399999999994 67835.6 69099.2 80909.2 True False 81147.08254021929 80790.15856380475 73179.83150467796 78336.91537292156 86376.49389301485 74946.86291081237 66901.1972717215 68032.99036521195 82920.97079296225 78573.14116865213 1.0327585397921455 1.0282159700144091 0.931359373142563 0.9969935554030667 1.0993132336101128 0.9538483735802774 0.8514512246382314 0.8658555500432847 1.055334807284563 1.0 16.261748616653165 -6.985497759749662 24.943760375157208 0.9277914100123449 1.0137826397971674 0.20902934211839708 0.06790039015325441 323.70587601628375 556769.9111675349 0.024298763194627506 0.02142101432042473 1.0339564344954005e-07 6.985497759749662 0.08599122978482254 ASNGDAWVEAHGK ddPTM_A459_Selumetinib_30min_R2 1 ASNGDAWVEAHGK 13 0 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 88.28200000000002 0.033727999999999994 2909100.0 37066.0 28700.0 32647.0 44823.0 34393.0 25140.0 45930.0 35625.0 36242.0 31034.0 False True 35006.02010695438 30901.197714955008 30546.527563366002 38718.03007601216 30072.24386267888 28602.806801801984 48065.836008568396 35728.66285196378 43491.412686088035 30137.967783984444 1.1615255666162352 1.0253245320467874 1.013556314822218 1.2846927952649558 0.9978192318149437 0.9490622263191131 1.5948598907890188 1.1855033858968513 1.4430771509816172 1.0 14.879294518223276 -7.23726716209425 24.998861653604756 1.3213188040216013 1.0735152250294915 0.3093990892469529 0.17053420107243644 877.9816359883912 908008.3083127567 0.06167128401950901 0.04774540291203243 5.790723626806804e-08 7.23726716209425 -0.2478035789921098 ASNT(ph)STPTKGNTETSASASQTNHVK ddPTM_A459_Selumetinib_30min_R2 1 ASNTSTPTKGNTETSASASQTNHVK 25 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 AS(0.085)NT(0.227)S(0.227)T(0.227)PT(0.227)KGNT(0.005)ETSASASQTNHVK 79.029 0.00012823 16248000.0 14597.0 16057.0 20178.0 25093.0 22315.0 18948.0 14853.0 16070.0 11079.0 20583.0 True False 13785.757176420788 17288.520268607404 18879.76944814529 21675.29011216058 19511.590201368872 21557.915007181557 15543.693930661148 16116.761039468283 13295.109573124264 19988.715308943498 0.6896769984138332 0.8649140278100839 0.9445214040192951 1.0843763482119564 0.9761302764985028 1.0785042797390765 0.7776234585574628 0.8062929903382637 0.6651307684179016 1.0 14.286898131423118 -11.236112381321172 6.6121047351224025 1.0014219193389031 0.8880551306233462 0.06059119389361167 0.13936406898797615 0.00318850713240195 0.00013828494191596308 0.14728430873748818 0.03529004669089319 5.8061415397554265e-12 11.236112381321172 -0.11336678871555694 ASNTS(ph)TPTKGNTETSASASQTNHVK ddPTM_A459_Selumetinib_30min_R2 1 ASNTSTPTKGNTETSASASQTNHVK 25 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 AS(0.047)NT(0.114)S(0.278)T(0.278)PT(0.278)KGNT(0.003)ETS(0.001)ASASQTNHVK 60.33 0.0030027 18005000.0 14985.0 13755.0 16492.0 20264.0 18591.0 13242.0 12105.0 13685.0 12079.0 17019.0 True False 14152.19368970785 14809.96427070405 15430.922675131933 17504.00824265022 16255.432374351274 15065.965301092361 12667.906485602452 13724.821084326288 14495.137515458788 16527.617249327563 0.8562754979265775 0.8960737683652858 0.9336447258154983 1.0590763313666633 0.9835315114774114 0.9115630567803311 0.7664690133187744 0.830417408467315 0.8770252418598653 1.0 14.012591128961207 -7.008698758817513 23.73889622643142 0.8521560265699286 0.9484847608272783 0.18040750551730678 0.07430989655143665 304.11443245991535 829929.6374677247 0.02800995251727295 0.023476395400953226 9.801696281167933e-08 7.008698758817513 0.09632873425734967 ASNTST(ph)PTKGNTETSASASQTNHVK ddPTM_A459_Selumetinib_30min_R1 1 ASNTSTPTKGNTETSASASQTNHVK 25 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 AS(0.039)NT(0.025)S(0.097)T(0.419)PT(0.419)KGNT(0.001)ETSASASQTNHVK 103.84 5.0658e-07 10985000.0 1220.5 1192.1 1841.6 1658.2 2039.5 1337.0 1475.5 1586.5 534.73 929.81 True False 1248.93527532041 1052.5283778077458 1591.5208351847007 1368.6264982690666 1855.0275851029712 1323.5509938988719 1364.2018470681344 1544.4208663217207 907.39775486603 1049.1601706163688 1.1904143049832665 1.0032103841584057 1.516947440208011 1.304497193660159 1.7681071365997103 1.261533778127797 1.3002798669593818 1.4720544198836603 0.864880101512951 1.0 10.03501922922575 -8.265674505374735 24.947113494308425 0.9324399975283209 1.3535236480601427 0.42275624674143897 0.19616058670874764 367.0783222259701 2162239.300807703 0.17292613025330808 0.05090348510791534 5.42407260990081e-09 8.265674505374735 0.42108365053182184 ASNTSTPT(ph)KGNTETSASASQTNHVK ddPTM_A459_Selumetinib_30min_R1 1 ASNTSTPTKGNTETSASASQTNHVK 25 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 ASNT(0.015)S(0.047)T(0.147)PT(0.79)KGNTETSASASQTNHVK 128.09 9.2705e-08 5247200.0 630.83 470.96 582.94 766.72 743.39 448.4 663.15 668.68 207.99 409.61 True False 645.5271116184965 415.81978425663607 503.7799498602137 632.8267451169088 676.1505057561644 443.88950311462514 613.1280615948721 650.944434221247 352.94383901143686 462.18743343927304 1.3966781978794596 0.8996778236967595 1.089990582633194 1.3691993752574758 1.4629357200924504 0.9604101518111654 1.3265788232977371 1.4083992491474235 0.7636378955288283 1.0 8.852334224220453 -8.267710428709039 24.997995211948506 0.8818189296940998 1.2283467426200891 0.3534418125808898 0.1929156970958574 636.229928620453 2536136.428146988 0.17306103351835875 0.04908891234279623 5.3987046793942645e-09 8.267710428709039 0.34652781292598933 ASNTSTPT(ph)KGNTETSASASQTNHVK ddPTM_A459_Selumetinib_30min_R2 1 ASNTSTPTKGNTETSASASQTNHVK 25 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 AS(0.001)NT(0.013)S(0.009)T(0.023)PT(0.94)KGNT(0.01)ET(0.003)S(0.001)ASASQTNHVK 83.115 0.00018688 3875500.0 6289.7 8555.5 12284.0 13669.0 18186.0 10199.0 8054.6 8908.5 10400.0 15398.0 True False 5940.143653664026 9211.679339731625 11493.660813807941 11807.25861965978 15901.312095097212 11603.819672696041 8429.154859887112 8934.422260118432 12480.290600279111 14953.419731191363 0.39724315644490804 0.6160249297702095 0.7686309232551866 0.7896025679685162 1.063389671456131 0.7759977236840089 0.5636941255855157 0.5974835469562929 0.834611134083694 1.0 13.868187834878954 -4.880723470735726 1.9294768602938457 0.7862795943429711 0.32471953575685863 0.431278608955049 0.14505127677615476 0.6805420548222837 3.2257411543944574 0.04286043074149944 0.5307252033273482 1.3160625448137362e-05 4.880723470735726 -0.4615600585861125 ASPAPGS(ph)GHPEGPGAHLDMNSLDR ddPTM_A459_Selumetinib_30min_R2 1 ASPAPGSGHPEGPGAHLDMNSLDR 24 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 1 AS(0.429)PAPGS(0.571)GHPEGPGAHLDMNSLDR 62.589 0.0043179 18052000.0 24138.0 6852.4 24160.0 27042.0 12345.0 13366.0 24774.0 20092.0 19859.0 26877.0 True False 22796.506592069938 7377.957046061239 22605.57190341908 23358.832949948057 10794.110734299731 15207.045175532434 25926.04008874969 20150.464393590333 23831.354906821438 26100.991175167586 0.8733962031970063 0.28266961191422524 0.8660809756882322 0.8949404562142295 0.41355175601795613 0.5826232832874323 0.9932971477886118 0.772019125954168 0.91304405824613 1.0 14.671816973177844 -7.257331164668749 24.96921872647802 0.9005916792242242 0.6453195261885121 0.3048084142305576 0.19682214809711163 472.5920353912776 2872366.953391775 0.0773715549962618 0.057711576248966306 5.529283213189227e-08 7.257331164668749 -0.25527215303571216 ASPDQNASTHT(ph)PQSSVK ddPTM_A459_Selumetinib_30min_R1 2 ASPDQNASTHTPQSSVK 17 0 Q14677-2;Q14677;Q14677-3;H0YD52 Q14677-2 CLINT1 Clathrin interactor 1 1 ASPDQNASTHT(0.991)PQS(0.008)S(0.001)VK;ASPDQNAS(0.044)T(0.03)HT(0.908)PQS(0.009)S(0.009)VK 226.08 4.8563999999999994e-51 18927000.0 5144.459999999999 5817.150000000001 5604.8099999999995 6452.85 9238.2 5604.85 8437.1 5512.65 1315.48 3239.89 True False 5264.31590862338 5136.075373680332 4843.707587017571 5325.980882496408 8402.606441136684 5548.470297796627 7800.68275425182 5366.436614389179 2232.273481142194 3655.761440701076 1.4400053159961737 1.4049262942866894 1.3249517687589263 1.4568732038146968 2.298455896926713 1.517733141999709 2.1338051951102863 1.4679394980871734 0.6106179293564912 1.0 11.83595621404419 -8.14679626728538 5.017780655055035 0.8167222283212315 1.6525783844642354 0.5255888061014656 0.3167499008104724 0.1780279246262493 6.443573344074788 0.23701138479501713 0.08488100215178966 7.131875164238194e-09 8.14679626728538 0.8358561561430039 ASPDQNASTHT(ph)PQSSVK ddPTM_A459_Selumetinib_30min_R2 4 ASPDQNASTHTPQSSVK 17 0 Q14677-2;Q14677;Q14677-3;H0YD52 Q14677-2 CLINT1 Clathrin interactor 1 1 ASPDQNASTHT(0.655)PQS(0.273)S(0.072)VK;ASPDQNASTHT(0.812)PQS(0.142)S(0.046)VK;ASPDQNASTHT(0.919)PQS(0.064)S(0.017)VK;ASPDQNASTHT(0.48)PQS(0.386)S(0.133)VK 148.01 0.00049118 63060000.0 81474.0 65150.5 111967.0 150518.0 145159.0 85460.0 82727.0 90556.0 88116.0 117548.0 True False 76946.00124626349 70147.33385812456 104763.16512045234 130017.18874196704 126922.82868207493 97231.33927136044 86573.96942044055 90819.50296764707 105741.66216674975 114154.08381361773 0.6740538636523523 0.6144969283153803 0.9177347110200789 1.1389622201711977 1.1118553488572958 0.8517552418896596 0.7583957273205579 0.795586981504143 0.9263064327982943 1.0 16.800622946721866 -5.273946673791687 11.271037582869985 0.9342649798909943 0.6442344243554526 0.5012987805599697 0.11697833507201058 0.4977732465234399 448.130857272679 0.03545011123858739 0.0773044886908575 5.321735998575881e-06 5.273946673791687 -0.2900305555355417 ASPDQNASTHTPQS(ph)SVK ddPTM_A459_Selumetinib_30min_R1 1 ASPDQNASTHTPQSSVK 17 0 Q14677-2;Q14677;Q14677-3;H0YD52 Q14677-2 CLINT1 Clathrin interactor 1 1 ASPDQNASTHT(0.303)PQS(0.576)S(0.121)VK 91.774 0.0054565 16496000.0 2482.6 2885.4 2486.9 3087.9 4179.8 2726.9 3757.3 2702.1 690.34 1564.9 True False 2540.439749701312 2547.576026613932 2149.192639563875 2548.656232061903 3801.737828003625 2699.469861827101 3473.883835980416 2630.431530342215 1171.4565595613033 1765.7701584168317 1.4387148506230503 1.442756303514642 1.2171417833285934 1.4433680509965112 2.1530196384178435 1.5287775982392935 1.9673476864594077 1.4896794567536629 0.6634252787529364 1.0 10.786081851378878 -8.189450852111147 5.6389071438569625 0.8356529187483557 1.5979105117906338 0.5554755365838839 0.2702411712958799 0.15718070193400085 8.99556567662909 0.20361371466015832 0.07328378472094883 6.4647114918746646e-09 8.189450852111147 0.7622575930422781 ASPDS(ph)PLTR ddPTM_A459_Selumetinib_30min_R2 1 ASPDSPLTR 9 0 F5GX43;A0A087WXP8;A0A1B0GX50;J3QQJ3;J3QRK4;E7ES00;Q9Y2T1 F5GX43 AXIN2 Axin-2 1 AS(0.368)PDS(0.624)PLT(0.007)R 107.45 0.012579 4035100.0 21824.0 19264.0 20520.0 23128.0 28076.0 22018.0 18032.0 23788.0 18309.0 17394.0 True False 20611.109448394007 20741.48685647711 19199.765540486733 19977.92650197465 24548.84187737539 25050.779640496265 18870.52372973015 23857.219141684596 21971.31159620291 16891.790024960555 1.220185037698048 1.2279034268024855 1.136632974487354 1.182700381217964 1.4533002032999587 1.4830150980730512 1.11714174174825 1.4123558904314706 1.300709490452846 1.0 14.044034598351686 -6.143028627920224 19.21614087203628 1.3158793695093813 1.1904580647335516 0.10061545054440701 0.14173206789382786 6.8485739807160115 1086.672236016366 0.04059706084118795 0.05241093783537715 7.194015547690412e-07 6.143028627920224 -0.1254213047758297 ASPEAAS(ph)TPRDPIDVDLPEEAER ddPTM_A459_Selumetinib_30min_R1 1 ASPEAASTPRDPIDVDLPEEAER 23 1 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;H3BVD2;H3BT29 P29590-2 PML Protein PML 1 ASPEAAS(0.872)T(0.128)PRDPIDVDLPEEAER 107.09 1.0737e-05 3266800.0 338.75 406.5 400.65 554.16 423.81 398.31 505.86 422.06 130.08 189.18 True False 346.6422159072423 358.90679102327675 346.2439306129181 457.38635887153885 385.4764603297326 394.3033630365439 467.70257292977755 410.8655977559068 220.73625933269733 213.46309576924813 1.6238976327878225 1.681352880833566 1.6220318053815026 2.142695238365557 1.8058224956431324 1.8471734498912291 2.191023095792447 1.9247617311802183 1.0340722293810984 1.0 7.737842863120635 -8.2648926703581 24.4138105805909 1.0170358807634858 1.8602124787351062 0.7666996289524708 0.1848439998486269 109.40183941401642 773415.0684364147 0.16681191855264893 0.049952701876221486 5.433846045983942e-09 8.2648926703581 0.8431765979716204 ASPEAAS(ph)TPRDPIDVDLPEEAER ddPTM_A459_Selumetinib_30min_R2 1 ASPEAASTPRDPIDVDLPEEAER 23 1 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;H3BVD2;H3BT29 P29590-2 PML Protein PML 1 AS(0.001)PEAAS(0.828)T(0.171)PRDPIDVDLPEEAER 65.598 0.0023626 1401700.0 2487.3 2384.1 1175.6 3375.6 3638.1 2329.1 3398.8 2283.4 1085.1 2150.5 True False 2349.065823450806 2566.9528039102515 1099.963175896501 2915.8374567652036 3181.0493529733394 2649.912383535282 3556.850934594433 2290.0443159627794 1302.1503202271997 2088.4094773299794 1.1248109381566658 1.2291424798512633 0.5266989964548515 1.3962000691995933 1.523192356433995 1.268866289058974 1.7031386675863243 1.0965494750055382 0.6235129338198523 1.0 11.028188895513782 -8.009649581152072 24.589016684624003 0.8278479106324719 1.2521406192976958 0.2509380725132426 0.30204264463815367 533.7314913290091 1360043.483998038 0.19013637498952904 0.0828843851844662 9.780260417805073e-09 8.009649581152072 0.42429270866522395 ASPEPQRENAS(ph)PAPGTTAEEAMSR ddPTM_A459_Selumetinib_30min_R1 1 ASPEPQRENASPAPGTTAEEAMSR 24 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 AS(0.003)PEPQRENAS(0.801)PAPGT(0.098)T(0.098)AEEAMSR 90.136 3.1473e-05 32354000.0 1011.3 806.58 2138.0 2404.6 1841.3 1092.8 1184.3 842.55 714.69 685.95 True False 1034.86132235275 712.1452386311311 1847.6713431933576 1984.6817499323354 1674.7547401079194 1081.8074241830118 1094.9672975145997 820.2028370118915 1212.7767311076677 773.9983642188164 1.3370329579407034 0.9200862321587557 2.3871773231177063 2.5641937266048895 2.163770387032047 1.3976869644613035 1.414689420719554 1.0596958274449435 1.566898312933391 1.0 9.596186707131626 -6.893116338698456 6.029148579303167 1.2847896453273735 1.886418080225735 0.278699047753158 0.4746424087981658 0.33344693287759586 16.629497288680817 0.19021696044731987 0.16767335752908255 1.2790386297098484e-07 6.893116338698456 0.6016284348983616 ASPEPQRENAS(ph)PAPGTTAEEAMSR ddPTM_A459_Selumetinib_30min_R2 1 ASPEPQRENASPAPGTTAEEAMSR 24 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 AS(0.004)PEPQRENAS(0.401)PAPGT(0.293)T(0.293)AEEAMS(0.009)R 48.146 0.029299 16452000.0 9666.5 17703.0 20550.0 21226.0 20011.0 12517.0 7214.7 10035.0 7041.3 17746.0 True False 9129.274628065463 19060.763175883218 19227.835373148246 18334.982183107655 17497.039279390196 14241.103131987096 7550.1978456568395 10064.200188616313 8449.756750360126 17233.62687035473 0.5297361197815902 1.1060215774238171 1.1157161239358127 1.063907343534719 1.0152847924013366 0.8263555454182794 0.4381084668047841 0.5839861953799604 0.4903063536147107 1.0 14.072938732722381 -7.026212392801039 4.439013392993561 0.5944217093838144 0.9844358268465946 0.3557355318183897 0.21141009777222092 0.19946645905243127 9.393065671832161 0.07911598358584705 0.06367711668100427 9.414290756818754e-08 7.026212392801039 0.39001411746278014 ASPEPQRENASPAPGT(ph)TAEEAMSR ddPTM_A459_Selumetinib_30min_R1 1 ASPEPQRENASPAPGTTAEEAMSR 24 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 ASPEPQRENAS(0.314)PAPGT(0.343)T(0.343)AEEAMS(0.001)R 83.411 0.00020464 37180000.0 1046.8 983.92 2444.9 2479.7 1978.6 1419.5 1307.0 1066.9 712.06 849.84 True False 1071.188403281774 868.722188988002 2112.8960088743897 2046.6669447339302 1799.6359793502015 1405.2211188028775 1208.4119377282627 1038.6023462203873 1208.3138131952683 958.9252421426037 1.1170718594166233 0.9059331747769475 2.203400135920269 2.1343342054078147 1.8767218759714055 1.4654125859311817 1.2601732487802813 1.0830900059526587 1.2600709211652783 1.0 9.905274536828216 -7.206738286864499 2.650806229602764 1.1404972694634836 1.6628662763813935 0.2700594997623249 0.38499371788341713 0.44827453398136335 6.201294768178276 0.19515003497750977 0.1365028677882379 6.212432930746168e-08 7.206738286864499 0.5223690069179099 ASPITNDGEDEFVPS(ph)DGLDKDEYTFSPGK ddPTM_A459_Selumetinib_30min_R1 1 ASPITNDGEDEFVPSDGLDKDEYTFSPGK 29 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 ASPITNDGEDEFVPS(0.643)DGLDKDEY(0.132)T(0.216)FS(0.01)PGK 71.295 0.00011071 5820400.0 1204.2 1830.2 1988.5 1954.1 1746.8 1415.7 1564.0 1712.6 836.23 1432.3 True False 1232.2555170346898 1615.9193331631034 1718.47262204864 1612.8531179999889 1588.8022484225876 1401.4593433527534 1446.0262208163767 1667.176284691195 1419.021234177286 1616.1496567834547 0.7624637432941631 0.9998574862053248 1.0633128032640453 0.9979602515338667 0.9830786658611212 0.8671593855621087 0.8947353450511096 1.0315729596535608 0.8780258859204265 1.0 10.658345083681459 ASPITNDGEDEFVPS(ph)DGLDKDEYTFSPGK ddPTM_A459_Selumetinib_30min_R2 3 ASPITNDGEDEFVPSDGLDKDEYTFSPGK 29 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 AS(0.003)PIT(0.006)NDGEDEFVPS(0.985)DGLDKDEY(0.002)T(0.003)FS(0.001)PGK;ASPITNDGEDEFVPS(1)DGLDKDEYTFSPGK;ASPITNDGEDEFVPS(0.512)DGLDKDEY(0.035)T(0.41)FS(0.042)PGK 132.94 5.6527e-14 0.0 37950.5 31784.8 31999.8 31646.8 31164.1 27877.9 25642.7 29343.1 22469.5 29278.6 True False 35841.36313788839 34222.59195575965 29940.967706747895 27336.45124622496 27248.987147411128 31717.82767462034 26835.13636004608 29428.483562988287 26964.027850285747 28433.250743061388 1.260543982880143 1.2036116540107904 1.0530265419635296 0.9614254625069881 0.958349342241873 1.1155188677242784 0.9437941726235682 1.0350024282809016 0.9483272979916242 1.0 14.79529142977108 -5.263521195104326 2.5160898091295283 0.9974654706789929 1.2538337279355527 0.7875554997694181 0.04894687217814499 0.12655128162288076 1.5306876497264266 0.013082705353169553 0.04311546734522778 5.451032920741826e-06 5.263521195104326 0.25636825725655976 ASPITNDGEDEFVPSDGLDKDEYT(ph)FSPGK ddPTM_A459_Selumetinib_30min_R2 4 ASPITNDGEDEFVPSDGLDKDEYTFSPGK 29 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 ASPITNDGEDEFVPS(0.022)DGLDKDEY(0.317)T(0.656)FS(0.005)PGK;ASPITNDGEDEFVPSDGLDKDEY(0.024)T(0.961)FS(0.014)PGK;ASPITNDGEDEFVPS(0.286)DGLDKDEY(0.213)T(0.41)FS(0.09)PGK;ASPITNDGEDEFVPS(0.257)DGLDKDEY(0.294)T(0.445)FS(0.004)PGK 123.44 1.1775e-11 0.0 36574.0 30626.199999999997 30519.6 31154.9 26343.6 23047.4 27220.0 24803.2 18017.9 26118.899999999998 True False 34541.3634973223 32975.1310612458 28556.00216322801 26911.548874799802 23034.081453227907 26221.970146533473 28485.783935406762 24875.373205609198 21621.983462189342 25364.779491947913 1.3617844976057256 1.3000361809458585 1.1258131446517465 1.0609809907215204 0.9081128207931045 1.0337945242085655 1.1230448088243628 0.9807052812545018 0.8524412155466706 1.0 14.63053899804113 -5.368597858247257 1.465274541354759 0.9912867067773692 1.3801340601845555 0.7941292264873921 0.06904606869055888 0.2397959098453795 0.883612516857745 0.02261367349279053 0.09797371168707744 4.279589780336243e-06 5.368597858247257 0.38884735340718635 ASPS(ph)CSSPTRDSSGVPVSK ddPTM_A459_Selumetinib_30min_R1 1 ASPSCSSPTRDSSGVPVSK 19 1 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 AS(0.003)PS(0.366)CS(0.312)S(0.312)PT(0.002)RDS(0.002)S(0.003)GVPVSK 90.193 0.0015106 47326000.0 1558.4 1379.0 4605.8 3906.9 2941.4 2165.2 1774.8 1920.2 1350.6 1445.6 True False 1594.707687881465 1217.5460389202933 3980.3576578484453 3224.6332565959583 2675.350889346349 2143.420053844306 1640.9254071003234 1869.2700583113583 2291.869556078883 1631.1568413364264 0.9776544152399851 0.7464310040981365 2.440205354248639 1.97689956899177 1.6401555151216494 1.3140490230774964 1.005988734814669 1.1459781248134562 1.4050577467468588 1.0 10.671679793468106 -6.930711569256497 4.267182797338213 1.1513680596937725 1.581732608269757 0.15646635696024414 0.45489692430747797 0.45429051449748753 16.29314317812453 0.18433933686385595 0.1596615878899595 1.1729741216481462e-07 6.930711569256497 0.4303645485759844 ASPS(ph)PQPSSQPLQIHR ddPTM_A459_Selumetinib_30min_R1 5 ASPSPQPSSQPLQIHR 16 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 AS(0.315)PS(0.685)PQPSSQPLQIHR;AS(0.002)PS(0.998)PQPSSQPLQIHR;ASPS(1)PQPSSQPLQIHR;ASPS(1)PQPSSQPLQIHR;ASPS(0.982)PQPS(0.009)S(0.009)QPLQIHR 311.81 4.421699999999998e-102 368813000.0 7926.52 9819.0 10229.529999999999 10380.6 9677.900000000001 8384.16 9577.5 8655.5 4295.39 7047.500000000001 True False 8111.19249367697 8669.386915270738 8840.416012786134 8567.82307799534 8802.535653772024 8299.822962608201 8855.061464110517 8425.928022973632 7288.963107126961 7952.115273463245 1.0200043906235334 1.0901988486259848 1.1117062201408485 1.0774269214364578 1.1069426625575574 1.0437251821921245 1.113547925249583 1.059583234550376 0.9166068217661195 1.0 12.957122954948654 -8.141404780156265 5.380100656867987 0.9599903475744711 1.0817890888736028 0.6681289221564242 0.03389764286233538 0.11842184467279292 4.60378276544557 0.02261758414821065 0.00820557048435973 7.220964665271713e-09 8.141404780156265 0.12179874129913171 ASPS(ph)PQPSSQPLQIHR ddPTM_A459_Selumetinib_30min_R2 6 ASPSPQPSSQPLQIHR 16 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 AS(0.013)PS(0.873)PQPS(0.027)S(0.087)QPLQIHR;AS(0.058)PS(0.942)PQPSSQPLQIHR;AS(0.001)PS(0.999)PQPSSQPLQIHR;AS(0.006)PS(0.994)PQPSSQPLQIHR;AS(0.262)PS(0.738)PQPSSQPLQIHR;ASPS(0.995)PQPS(0.004)S(0.001)QPLQIHR 301.04 4.527899999999998e-88 306415000.0 134709.6 125529.5 156966.8 188569.0 153623.9 107304.1 113131.2 122838.4 110173.5 131224.4 True False 127222.97971725509 135157.20900903989 146867.72698052946 162885.5769003314 134324.2922669089 122084.26576536374 118392.02496521997 123195.8394070083 132211.27850479368 127435.61061006256 0.9983314640877101 1.060592156007354 1.1524857634176275 1.2781794360348884 1.0540561749095774 0.9580074610300783 0.9290340776683303 0.966730090727721 1.0374751442855645 1.0 16.959408955105758 -6.539232751893543 6.5579178724333165 0.9758683981046282 1.125764025412628 0.47292003024300533 0.07173468898899629 0.1451811139923526 25.90987520517303 0.025655396353573442 0.026291905902783075 2.889131092347938e-07 6.539232751893543 0.14989562730799977 ASPSCS(ph)SPTR ddPTM_A459_Selumetinib_30min_R2 1 ASPSCSSPTR 10 0 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 ASPS(0.018)CS(0.581)S(0.379)PT(0.021)R 93.561 0.025047 314970000.0 27285.0 25424.0 27630.0 35501.0 35880.0 21981.0 28589.0 27985.0 24228.0 35246.0 True False 25768.60893050909 27373.93904895527 25852.31588126941 30665.70255735914 31372.43362873023 25008.68322634884 29918.445148028797 28066.43171683384 29074.276986880996 34228.35639989418 0.7528438885423302 0.7997444787924406 0.7552894325171083 0.8959151353657736 0.9165626669946447 0.7306422468601547 0.8740836047891943 0.819976027739404 0.8494207740273173 1.0 15.062904397265234 -14.522878745187835 0.15727347726106874 1.6424901920717252 0.7741425743629483 0.4930509668997164 0.057221519003758 122.36205369786748 1.112051074153306 24.582548509957554 0.2630650629204738 3.0000000006389823e-15 14.522878745187835 -0.8683476177087769 ASPSCS(ph)SPTRDSSGVPVSK ddPTM_A459_Selumetinib_30min_R1 3 ASPSCSSPTRDSSGVPVSK 19 1 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 AS(0.001)PS(0.105)CS(0.433)S(0.433)PT(0.026)RDS(0.002)S(0.001)GVPVSK;ASPSCS(0.616)S(0.383)PT(0.001)RDSSGVPVSK;AS(0.003)PS(0.174)CS(0.656)S(0.145)PT(0.014)RDS(0.003)S(0.004)GVPVS(0.002)K 238.72 4.8933999999999994e-29 25938700.0 3887.0099999999998 2276.25 11339.599999999999 10082.400000000001 7564.5 4779.33 3709.59 4096.62 3297.92 2267.19 True False 3977.5697701951563 2009.7455918000849 9799.74460396418 8321.698110088073 6880.292310620946 4731.2542794844385 3429.772639691955 3987.96432990286 5596.3293694533295 2558.2059208007267 1.554827833777417 0.785607435061767 3.8307098440679193 3.2529430263703536 2.6894990175252946 1.8494423146372598 1.340694512433317 1.5588910562190452 2.18759925616217 1.0 11.320916682173683 -6.921937072907604 4.878813092752535 1.5706092148919562 2.4520352663483593 0.20682339834827268 0.8333970974822245 0.38756299065199573 16.76719115635382 0.33091690783261596 0.28931259047089203 1.196913945571577e-07 6.921937072907604 0.8814260514564032 ASPSCS(ph)SPTRDSSGVPVSK ddPTM_A459_Selumetinib_30min_R2 3 ASPSCSSPTRDSSGVPVSK 19 1 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 AS(0.075)PS(0.334)CS(0.499)S(0.091)PT(0.001)RDSSGVPVSK;ASPS(0.037)CS(0.473)S(0.473)PT(0.016)RDS(0.001)SGVPVSK;AS(0.002)PS(0.111)CS(0.44)S(0.44)PT(0.008)RDSSGVPVSK 105.38 0.00047635 41901100.0 71449.0 134857.0 108870.0 148850.0 113950.0 50432.5 30568.1 41954.7 23695.1 115934.0 True False 67478.15061300874 145200.0982664005 101865.42272869346 128576.37321942754 99634.5822740748 57379.1190943468 31989.577219541043 42076.78123102551 28434.78209641094 112586.68418729311 0.5993439730470767 1.289673812800575 0.9047732728253695 1.1420211381794925 0.8849588474275351 0.5096439202250064 0.2841328657154954 0.3737278660860893 0.25255901531932834 1.0 16.78067668202413 -6.74289906821755 3.345833785158205 0.4219832159691821 1.0013764835316992 0.4632147066185145 0.25689078036671864 0.1818695748032617 4.24489968735146 0.08640591862778095 0.08144227758840644 1.8075941693464446e-07 6.74289906821755 0.5793932675625171 ASPSCSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 6 ASPSCSSPTR 10 0 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 ASPSCS(0.002)S(0.997)PTR;ASPSCS(0.002)S(0.99)PT(0.007)R;ASPSCS(0.231)S(0.756)PT(0.012)R;ASPS(0.002)CS(0.022)S(0.945)PT(0.031)R;AS(0.001)PS(0.028)CS(0.122)S(0.814)PT(0.035)R;ASPSCS(0.05)S(0.904)PT(0.046)R 152.69 0.00062396 172499430.0 15805.890000000001 19560.3 17196.88 17315.1 18253.48 16325.779999999999 16247.710000000001 16149.42 9456.470000000001 14018.18 True False 16174.136484091861 17270.170982663236 14861.638151700196 14291.342829682011 16602.455956913633 16161.557475822217 15022.132153593639 15721.084920890851 16046.938916757932 15817.54995163631 1.0225437272868332 1.0918360324745902 0.9395663802005426 0.9035117874373196 1.0496224767854219 1.0217484708591245 0.9497129580450361 0.9939013923748994 1.014502180541424 1.0 13.949238531423338 -5.257071439825634 24.997653402982863 0.983435500794776 1.0571898794887318 0.30983217208332503 0.04364387737882587 459.4866202707843 2629613.1272838 0.011718366920584884 0.028817253096756614 5.532590926687346e-06 5.257071439825634 0.07375437869395574 ASPSCSS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 ASPSCSSPTR 10 0 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 ASPSCS(0.036)S(0.933)PT(0.03)R;ASPS(0.011)CS(0.037)S(0.861)PT(0.091)R 139.31 0.0015418 345083700.0 63878.0 52885.0 59441.0 65391.0 73053.0 47033.0 58609.0 68775.0 54316.0 74133.0 True False 60327.91648389442 56941.10944792318 55616.630774467434 56484.63299423314 63875.42903789378 53511.36882693528 61334.43463153032 68975.12386368592 65180.71771584236 71992.58766933411 0.8379739975590798 0.7909301678313997 0.7725327367022513 0.7845895643266797 0.8872500781785635 0.7432899769170115 0.8519548555921164 0.9580864655190953 0.9053809541507378 1.0 16.135560754393488 -7.632697729177323 3.86557222867341 0.9489555456441912 0.8033090693618032 0.7157048017680371 0.04260191754087853 0.12250052849330006 3.4180473336429547 0.02122166349317855 0.011494519089534352 2.329712183188777e-08 7.632697729177323 -0.14564647628238792 ASPSCSSPT(ph)RDSSGVPVSK ddPTM_A459_Selumetinib_30min_R1 1 ASPSCSSPTRDSSGVPVSK 19 1 Q8N5I9;A0A087WT30;J3KN91 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 ASPS(0.039)CS(0.251)S(0.251)PT(0.446)RDS(0.011)S(0.003)GVPVSK 145.44 7.0503e-05 43106000.0 1962.8 1339.4 6463.4 5621.3 3295.1 2378.1 2221.0 2131.7 1918.2 1475.5 True False 2008.5294210560448 1182.5824253298335 5585.705780914854 4639.645479869682 2997.0587867971567 2354.178473142039 2053.4681818626423 2075.160391262535 3255.0453002151 1664.894797587089 1.206400202563538 0.7103045952475407 3.3549902306200647 2.786749941554182 1.800149049141577 1.4140103486141706 1.2333921547708047 1.2464213320085082 1.955105694925947 1.0 10.701215302922876 -6.65935321430034 4.1508908696061235 1.3758181500993716 2.04449134466205 0.14954179805031065 0.7264335143823669 0.47600853784478975 14.93525022287565 0.27221804549776446 0.26920887729152837 2.1910222390149252e-07 6.65935321430034 0.6686731945626783 ASPSPQPS(ph)SQPLQIHR ddPTM_A459_Selumetinib_30min_R1 1 ASPSPQPSSQPLQIHR 16 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 AS(0.266)PS(0.178)PQPS(0.437)S(0.12)QPLQIHR 142.19 0.00039501 36873000.0 381.81 426.61 607.56 743.32 439.71 622.89 539.39 550.99 166.1 312.97 True False 390.70543012706753 376.6623028743917 525.0566890881934 613.5131158445078 399.9383081371056 616.6242921388688 498.7033780346196 536.375955332244 281.85956853598594 353.1427480859583 1.1063668509255813 1.0666007016027086 1.4868114719444545 1.7372949583978794 1.1325117400959819 1.7461049263533979 1.4121863771452288 1.5188644202363315 0.7981462738897264 1.0 8.46410766031639 -8.262207393782004 24.9844200801263 0.8990730918487279 1.4067244888405384 0.424865506945436 0.2334393064013841 66.41636852892077 2160394.236083476 0.19177283318712643 0.0607096751397908 5.467548022520904e-09 8.262207393782004 0.5076513969918105 ASPTGTPSRAS(ph)PTGTPSR ddPTM_A459_Selumetinib_30min_R1 1 ASPTGTPSRASPTGTPSR 18 1 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 ASPTGTPSRAS(0.903)PT(0.097)GTPSR 225.17 1.5748e-14 4137700.0 481.65 943.54 841.61 1158.1 994.76 728.84 740.0 520.36 417.29 518.24 True False 492.8715078722454 833.0698981601547 727.3239846328173 955.8595752294087 904.784133639142 721.5085313337719 684.1812042225823 506.55836243250593 708.1106523442589 584.7611520850787 0.8428595266884897 1.424632767053152 1.2437966886811878 1.6346153841121405 1.5472712754822369 1.2338516824537573 1.1700182233087855 0.866265415591091 1.21093997065187 1.0 9.191703660511331 -7.30385804173171 2.608244650178342 1.031494759502699 1.3533281348226114 0.2683387300756048 0.21638074637308757 0.3737749500413984 5.015112336492073 0.10418055861093732 0.06746337922624412 4.967546696072693e-08 7.30385804173171 0.3218333753199123 ASPTGTPSRASPT(ph)GTPSR ddPTM_A459_Selumetinib_30min_R2 2 ASPTGTPSRASPTGTPSR 18 1 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 ASPT(0.009)GT(0.012)PS(0.004)RAS(0.135)PT(0.829)GT(0.012)PSR;ASPTGTPS(0.065)RAS(0.321)PT(0.594)GT(0.007)PS(0.012)R 119.37 0.010122 2238300.0 6948.700000000001 6705.700000000001 9939.5 5565.29 9224.5 6696.799999999999 2437.42 4608.6 3193.67 8918.7 True False 6562.519071850046 7220.005627776092 9300.003391309345 4807.287901339264 8065.635841923689 7619.223412502291 2550.764859656104 4622.010263005201 3832.4932385955212 8661.193957434501 0.7576921962608841 0.8336039653723102 1.073755354863807 0.5550375531323642 0.9312383352182521 0.8796966619090876 0.2945049922899609 0.5336458559547451 0.44249017600002216 1.0 13.080350200807933 -7.2357919643275626 24.86634859542458 0.5287973843993549 0.8403049095664774 0.28007577453311705 0.2090368991913639 779.7465264183002 756001.126344135 0.07569043994163076 0.058607550340830615 5.81042681840349e-08 7.2357919643275626 0.31150752516712255 ASPTPLAS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 ASPTPLASPGK 11 0 A0A1B0GTL5 A0A1B0GTL5 1 AS(0.001)PT(0.106)PLAS(0.893)PGK 143.76 0.0008131 11699000.0 3140.1 3322.7 3377.1 4231.4 3182.6 3054.5 3412.6 3237.6 2076.4 2703.6 True False 3213.258220429022 2933.6767393186765 2918.508369082457 3492.4654232153716 2894.7343919336663 3023.774503264102 3155.1848344999785 3151.728330793069 3523.4991457442534 3050.6333952941086 1.0533085441816044 0.9616615171931675 0.9566893136305835 1.144832882444292 0.9488961854279405 0.9911956342996051 1.0342720431000167 1.0331389984961512 1.1550057608297297 1.0 11.574893101560091 -8.018142929309693 20.8407163566124 1.083026131542872 1.0122590262281095 0.1331868524042359 0.06475066464275742 152.97331613370193 175711.901209373 0.04043879105667299 0.01608964121190987 9.590849381015875e-09 8.018142929309693 -0.07076710531476249 ASPVPSDPEKPGT(ph)PGEGMLSSDLDR ddPTM_A459_Selumetinib_30min_R2 1 ASPVPSDPEKPGTPGEGMLSSDLDR 25 1 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 ASPVPS(0.054)DPEKPGT(0.885)PGEGMLS(0.03)S(0.03)DLDR 73.29899999999998 0.00071166 6261600.0 29119.0 26718.0 28108.0 28633.0 27056.0 21246.0 24786.0 27495.0 18659.0 26140.0 True False 27500.682552592778 28767.18468808948 26299.56188167645 24733.136005319946 23656.983396291107 24172.443648014527 25938.598112527266 27575.005897957715 22391.32137602 25385.27028012355 1.083332272972708 1.1332234942014363 1.0360166187503146 0.9743105246622401 0.9319177276916497 0.9522232137485392 1.021797200750585 1.086260086801152 0.882059601057398 1.0 14.63170400025193 -5.499184936020891 3.4378780646575775 0.981153985067885 1.1072484910097222 0.4923359396434116 0.05253762612999541 0.20160036548129856 4.9323796354317215 0.014752068035748932 0.03134953332785104 3.1682180505304756e-06 5.499184936020891 0.12609450594183724 ASPVTS(ph)PAAAFPTASPANK ddPTM_A459_Selumetinib_30min_R2 2 ASPVTSPAAAFPTASPANK 19 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;H0YHQ7 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 ASPVT(0.021)S(0.671)PAAAFPT(0.071)AS(0.237)PANK;ASPVT(0.003)S(0.997)PAAAFPTASPANK 228.49 4.141499999999999e-40 3248300.0 25174.0 20778.0 23532.0 27320.0 28377.0 20454.5 25157.0 29058.0 19635.8 21403.1 True False 23774.92985950652 22371.60578819982 22017.97673970438 23598.968870371304 24812.02756640127 23271.92170753615 26326.850347649804 29142.553969189143 23563.508670092382 20785.1368910678 1.143842832698569 1.0763270843702641 1.0593135303894188 1.1353771203937906 1.193738953774415 1.1196424555441356 1.2666190502196548 1.4020862177584628 1.133671083985911 1.0 14.343264629143407 -6.4614681897988575 1.3182240486665224 1.2215076795164252 1.0932333031683168 0.10278687527912089 0.10226329524961779 0.690474544677612 2.4711844716444733 0.04286354871595717 0.05069076316249343 3.4556663991959485e-07 6.4614681897988575 -0.12827437634810845 ASPVTSPAAAFPTAS(ph)PANK ddPTM_A459_Selumetinib_30min_R1 1 ASPVTSPAAAFPTASPANK 19 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;H0YHQ7 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 ASPVT(0.037)S(0.005)PAAAFPT(0.068)AS(0.891)PANK 176.85 8.2411e-13 8401700.0 1501.7 3015.2 1744.3 1760.4 1856.0 2021.4 2135.9 1851.9 1212.2 2096.5 True False 1536.6866882004601 2662.17898227155 1507.433640754058 1452.979186800666 1688.125127703415 2001.066551284353 1974.787343377045 1802.7815961810243 2057.014864414942 2365.6061966393304 0.6495953089671203 1.1253686205478926 0.6372293253609055 0.6142100865582881 0.7136120670049095 0.8459001139442159 0.8347912455515641 0.7620801800156441 0.8695508438121338 1.0 11.207994212337258 -8.83173601451184 0.8027127564341964 1.0018239233566548 0.7693756297608945 0.20412360422226117 0.14000299366318483 1.972548735929272 2.4193706666677763 0.14271295077458668 0.04959666278232466 1.473207718238812e-09 8.83173601451184 -0.23244829359576036 ASPVTSPAAAFPTAS(ph)PANK ddPTM_A459_Selumetinib_30min_R2 1 ASPVTSPAAAFPTASPANK 19 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;H0YHQ7 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 ASPVTS(0.001)PAAAFPT(0.008)AS(0.991)PANK 176.85 8.2411e-13 6452800.0 28870.0 16938.0 23939.0 28810.0 24580.0 17700.0 28654.0 32875.0 26069.0 23346.0 True False 27265.5209757668 18237.090135745908 22398.79080281246 24886.02829997794 21492.04065201194 20138.014335397584 29986.467776823836 32970.660807250766 31283.52842871889 22671.940319807345 1.2026108304434038 0.804390355589154 0.987952089095954 1.097657630927877 0.947957711111096 0.8882351510869144 1.3226246785162077 1.4542496293731835 1.379834632035796 1.0 14.468620245263144 -7.272253383620637 23.803871987710142 1.3270314378076822 0.9829258701876524 0.4797701560849794 0.15147798541692373 287.7916220977357 633485.2765318378 0.06032004408319541 0.041170688510863356 5.342525655498893e-08 7.272253383620637 -0.34410556762002975 ASPVTT(ph)SPTAATTQNPVLSK ddPTM_A459_Selumetinib_30min_R1 1 ASPVTTSPTAATTQNPVLSK 20 0 Q96JN0-3;Q96JN0-2;Q96JN0 Q96JN0-3;Q96JN0-2 LCOR Ligand-dependent corepressor 1 ASPVT(0.004)T(0.821)S(0.131)PT(0.042)AAT(0.001)T(0.001)QNPVLSK 130.95 0.00037754 9237000.0 2189.2 2859.0 3443.4 4047.0 3265.6 2708.7 2881.0 2242.8 1287.6 1974.4 True False 2240.2041005583314 2524.266950886961 2975.8051932422873 3340.26742159867 2970.227056588508 2681.4529373028217 2663.683850493592 2183.313658358877 2184.9631574168293 2227.8334722846157 1.0055527616527953 1.1330590828668878 1.3357395111720967 1.4993344265418846 1.3332356720282943 1.2036146196120416 1.195638670318575 0.9800165432113361 0.9807569482184755 1.0 11.121425681752925 -7.648783391862721 2.409327251159053 0.9771767476490321 1.2648616977741582 0.4733346256686798 0.12432211433058613 0.2875231921083542 3.346361812354812 0.0847794042765332 0.04081851222750562 2.2450013584827165e-08 7.648783391862721 0.2876849501251262 ASPVTT(ph)SPTAATTQNPVLSK ddPTM_A459_Selumetinib_30min_R2 1 ASPVTTSPTAATTQNPVLSK 20 0 Q96JN0-3;Q96JN0-2;Q96JN0 Q96JN0-3;Q96JN0-2 LCOR Ligand-dependent corepressor 1 ASPVTT(0.5)S(0.5)PTAATTQNPVLSK 213.03 9.3938e-17 5647300.0 26913.0 30521.0 33240.0 34622.0 36257.0 23775.0 23631.0 31887.0 22113.0 33997.0 True False 25417.28320127509 32861.86255951714 31101.37458897557 29906.42387371872 31702.071518307457 27049.7904420383 24729.888323938165 31979.785890822965 26536.217888843465 33015.418275185926 0.7698610082543912 0.9953489695514718 0.9420257629251684 0.9058320456353601 0.9602201993646838 0.819307822078046 0.7490405881825496 0.9686318563123784 0.8037522853008296 1.0 15.010852303243947 -6.7617875255498285 24.99999982350753 0.8587418838159611 0.9201705943401081 0.05731699040442961 0.08898029022774814 22.862155487063404 1641625.7837700555 0.02927660893474258 0.027439513158498668 1.7306628624933312e-07 6.7617875255498285 0.061428710524147 ASPVTTS(ph)PTAATTQNPVLSK ddPTM_A459_Selumetinib_30min_R2 3 ASPVTTSPTAATTQNPVLSK 20 0 Q96JN0-3;Q96JN0-2;Q96JN0 Q96JN0-3;Q96JN0-2 LCOR Ligand-dependent corepressor 1 ASPVTT(0.013)S(0.961)PT(0.025)AATTQNPVLSK;ASPVTT(0.038)S(0.961)PT(0.001)AATTQNPVLSK;AS(0.001)PVT(0.021)T(0.111)S(0.745)PT(0.119)AAT(0.001)T(0.002)QNPVLSK 131.48 0.00015524 17325600.0 71557.0 75258.0 80873.0 83981.0 84069.0 66022.0 70914.0 64256.0 59575.0 80186.0 True False 67580.14840536706 81030.04660738954 75669.71922786461 72542.64292469436 73507.50063360426 75115.93121195587 74211.64151342527 64442.97432184655 71491.66466457966 77870.82183175167 0.8678494308353554 1.0405700710654333 0.9717339235401575 0.9315766961010195 0.943967186996243 0.9646222994056999 0.9530096096040639 0.827562529917593 0.9180802639921424 1.0 16.24879523178791 -7.567502282806874 24.99994580746246 0.9017499633477676 0.9569351193871164 0.07179272375945511 0.056074863349352036 232.89032024819377 130472.20840477395 0.025088244104681825 0.014484712994185476 2.707058974615357e-08 7.567502282806874 0.055185156039348815 ASQEPS(ph)PKPGTEVIPAAPR ddPTM_A459_Selumetinib_30min_R1 5 ASQEPSPKPGTEVIPAAPR 19 1 I3L4I0;I3L1Y9;Q96CP2 I3L4I0 FLYWCH2 FLYWCH family member 2 1 ASQEPS(1)PKPGTEVIPAAPR;ASQEPS(0.959)PKPGT(0.041)EVIPAAPR;AS(0.01)QEPS(0.989)PKPGT(0.001)EVIPAAPR;ASQEPS(0.991)PKPGT(0.009)EVIPAAPR;ASQEPS(0.6)PKPGT(0.4)EVIPAAPR 197.28 1.2724e-14 74047500.0 8538.609999999999 10010.45 11924.3 11844.4 8559.85 10580.5 8819.369999999999 9037.300000000001 5688.870000000001 8684.25 True False 8737.542999757154 8838.421860268056 10305.045555491377 9775.99788692445 7785.613078864266 10474.069776325361 8154.117820384479 8797.601446712448 9653.596891374551 9798.958079258346 0.8916808225001074 0.9019756783097709 1.0516470702435474 0.997656874113739 0.7945347878713995 1.0688962736248497 0.8321413107832828 0.8978098870873333 0.9851656485609951 1.0 13.258412640645014 ASQEPS(ph)PKPGTEVIPAAPR ddPTM_A459_Selumetinib_30min_R2 1 ASQEPSPKPGTEVIPAAPR 19 1 I3L4I0;I3L1Y9;Q96CP2 I3L4I0 FLYWCH2 FLYWCH family member 2 1 ASQEPS(0.978)PKPGT(0.022)EVIPAAPR 164.69 1.0282e-06 14327000.0 14017.0 14444.0 17689.0 15570.0 14513.0 13333.0 14586.0 12057.0 9311.7 14561.0 True False 13237.99125449682 15551.808355219866 16550.908998326988 13449.339140251868 12689.74719213382 15169.499725076616 15264.277901610678 12092.0838738562 11174.300190636448 14140.586095978528 0.9361699129473566 1.0997994177654828 1.1704542432674652 0.9511161028945437 0.8973989554607419 1.0727631529637023 1.0794657164848152 0.8551331459517858 0.7902289279094543 1.0 13.787554297450525 -7.769250622343411 24.99839425918868 0.8670107157860982 1.031270555004325 0.3465791507446634 0.09231786058291952 193.33805071324474 618729.9604711672 0.051133860155403756 0.025270257294392126 1.7011765113745664e-08 7.769250622343411 0.16425983921822684 ASQEPSPKPGT(ph)EVIPAAPR ddPTM_A459_Selumetinib_30min_R2 1 ASQEPSPKPGTEVIPAAPR 19 1 I3L4I0;I3L1Y9;Q96CP2 I3L4I0 FLYWCH2 FLYWCH family member 2 1 ASQEPS(0.292)PKPGT(0.708)EVIPAAPR 180.32 5.1414e-12 16389000.0 62791.0 62868.0 65153.0 58905.0 60065.0 50348.0 52590.0 53798.0 40324.0 56971.0 True False 59301.327592288675 67689.77344751879 60961.126913222804 50882.03738320719 52519.097712086965 57282.979986361424 55035.53920510804 53954.54327326163 48389.9267466976 55326.09920156534 1.0718508705311158 1.2234691117642293 1.1018511659592665 0.9196751283301677 0.9492644243858248 1.0353699395590268 0.99474822912422 0.9752096036392007 0.8746310953606595 1.0 15.755672588872509 -5.62731472656388 5.0503979013160185 0.9672518243675288 1.1509953179218486 0.6719826050598774 0.05432703267430516 0.11387494337511282 4.60872095647283 0.014827424932960838 0.026272836316541162 2.3587682504076282e-06 5.62731472656388 0.18374349355431985 ASQGLLSSIENS(ph)ESDSSEAKEEGSR ddPTM_A459_Selumetinib_30min_R2 1 ASQGLLSSIENSESDSSEAKEEGSR 25 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ASQGLLS(0.04)S(0.142)IENS(0.392)ES(0.386)DS(0.032)S(0.008)EAKEEGSR 62.78100000000001 0.0022103 11138000.0 19489.0 17097.0 24163.0 23790.0 24744.0 15932.0 16251.0 19463.0 15905.0 21168.0 True False 18405.879400648388 18408.28492448033 22608.378886685223 20549.76095996095 21635.437505833353 18126.48838370363 17006.703700745606 19519.634107726906 19086.444422830704 20556.82483893096 0.8953658721550682 0.8954828904130331 1.0997991695618765 0.9996563730524847 1.0524698087060456 0.8817747159753627 0.8273020679992341 0.9495451880662135 0.9284723965096197 1.0 14.32732982584781 -6.7776235853983025 24.976774587152583 0.9086331406608094 0.9901811656954924 0.19159169088872519 0.07189916152198259 386.3630210175095 596262.9060502168 0.026652486857403807 0.02357449391197413 1.668692886555002e-07 6.7776235853983025 0.08154802503468306 ASQGLLSSIENSES(ph)DSSEAKEEGSR ddPTM_A459_Selumetinib_30min_R1 1 ASQGLLSSIENSESDSSEAKEEGSR 25 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ASQGLLSSIENS(0.007)ES(0.988)DS(0.004)S(0.001)EAKEEGSR 151.53 2.2783e-10 27334000.0 844.96 1892.2 1627.0 2040.0 1417.3 1483.1 1395.0 971.6 683.08 887.77 True False 864.6459239940473 1670.6603443400845 1406.0623364712787 1683.752295542695 1289.105465244639 1468.181360547057 1289.7740268790571 945.8300117984144 1159.136869810723 1001.7239271120914 0.8631579026835952 1.667785204209403 1.4036425590081194 1.6808546246837186 1.286886965913903 1.4656546787094662 1.2875543769802889 0.9442022758956994 1.1571420412732314 1.0 9.968269244427695 -7.5904525256302255 4.392799366887657 1.0406201296227238 1.4136252372840266 0.3470559761473069 0.21992415676709584 0.22547616408005985 8.576530431173996 0.10393151488999873 0.05827285382174551 2.5677188798120314e-08 7.5904525256302255 0.3730051076613028 ASQGLLSSIENSES(ph)DSSEAKEEGSR ddPTM_A459_Selumetinib_30min_R2 2 ASQGLLSSIENSESDSSEAKEEGSR 25 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ASQGLLS(0.004)S(0.018)IENS(0.131)ES(0.512)DS(0.027)S(0.025)EAKEEGS(0.281)R;ASQGLLS(0.002)S(0.004)IENS(0.018)ES(0.623)DS(0.284)S(0.07)EAKEEGSR 82.15100000000002 8.6039e-05 16258400.0 33541.9 23385.8 38018.8 36930.2 31783.6 27823.0 29339.1 32813.3 20953.8 27560.2 True False 31677.775476864328 25179.415662801217 35572.7117997396 31900.243051851587 27790.66001901084 31655.365697952926 30703.42628432372 32908.78127046578 25145.145498089285 26764.465416000778 1.183575871383786 0.9407778287904095 1.3291022722416466 1.1918879213922373 1.0383416812949517 1.1827385754182929 1.1471712887629015 1.2295699076728692 0.9394973935499042 1.0 14.708031216607855 -8.270688251611185 24.965375072937 0.9697486666782641 1.1519838541617864 0.35435708980172276 0.10015126326591538 809.2554981362182 2184388.1356099625 0.09012943914600882 0.024554434735375972 5.361814049985256e-09 8.270688251611185 0.1822351874835223 ASQGLLSSIENSESDS(ph)SEAKEEGSR ddPTM_A459_Selumetinib_30min_R1 1 ASQGLLSSIENSESDSSEAKEEGSR 25 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ASQGLLSSIENS(0.001)ES(0.161)DS(0.628)S(0.209)EAKEEGSR 132.7 2.942e-08 27332000.0 1018.1 2032.4 1993.3 2084.5 1448.9 1713.6 1779.3 1403.9 720.37 1023.8 True False 1041.8197491222531 1794.4456631628727 1722.6208084131536 1720.4812059111498 1317.8472508240716 1696.3627398243123 1645.0859684773516 1366.664011490114 1222.4152762568808 1155.2147026564971 0.9018407978417481 1.5533438581039691 1.4911693942709232 1.48931726886334 1.1407812312235894 1.4684393610325486 1.4240521391342762 1.1830389695935954 1.0581715013199289 1.0 10.173945293594887 -8.026400898624463 2.7589355132440168 1.0284528201889436 1.3669071651170421 0.32457278712334947 0.18704338784080055 0.3224974376688481 4.661126624918583 0.14358299165871985 0.049838364944171556 9.410205364033501e-09 8.026400898624463 0.33845434492809856 ASQGS(ph)DLEQNEASR ddPTM_A459_Selumetinib_30min_R2 1 ASQGSDLEQNEASR 14 0 Q5HYY5;Q96T21-2;Q96T21-3;Q96T21 Q5HYY5 SECISBP2 Selenocysteine insertion sequence-binding protein 2 1 ASQGS(1)DLEQNEASR 176.28 6.910899999999999e-05 6302700.0 9093.0 5207.0 10000.0 10305.0 11492.0 9862.7 8078.0 13723.0 7253.8 10568.0 True False 8587.647462163066 5606.360156856121 9356.610887176763 8901.441222883466 10048.272220216493 11221.197400323488 8453.643006253329 13762.931658035044 8704.762688106219 10262.874381038473 0.8367682525696183 0.5462758237803578 0.9116949637875225 0.8673438738887451 0.9790894682274904 1.09337764291996 0.8237110474500349 1.3410406429083086 0.8481797949499414 1.0 13.325147230815961 -5.789365531335405 1.2216734987157718 1.0311665172767457 0.6926495594376464 0.3624711277151622 0.15582537603048013 0.4889956314632383 1.44456304376214 0.052406867691112156 0.13191160270615965 1.6241811606100822e-06 5.789365531335405 -0.3385169578390993 ASQPDLVDT(ph)PTSSKPQPK ddPTM_A459_Selumetinib_30min_R1 1 ASQPDLVDTPTSSKPQPK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ASQPDLVDT(0.464)PT(0.299)S(0.175)S(0.061)KPQPK 78.95 0.017311 8350600.0 2020.4 4501.1 3252.9 4093.6 2804.6 2889.4 3439.1 2258.4 1433.9 2281.0 True False 2067.471388985955 3974.1091194953797 2811.1740469006913 3378.729606389006 2550.924425192348 2860.3352593652935 3179.6859181647037 2198.4998956829345 2433.2235720875988 2573.78856882152 0.8032794200856225 1.5440697684483986 1.0922319264895426 1.3127455950805045 0.9911165416203394 1.111332645585172 1.2354106925032349 0.8541882275472138 0.9453859581021129 1.0 11.329677828803007 -7.761227172817036 24.99999997588881 0.9248402927419437 1.1662329412640622 0.22693943458646093 0.18734094192059955 7.5742608829778435 892711.860915929 0.08924577157543381 0.04733908381635634 1.7328973084955556e-08 7.761227172817036 0.2413926485221185 ASQPDLVDT(ph)PTSSKPQPK ddPTM_A459_Selumetinib_30min_R2 2 ASQPDLVDTPTSSKPQPK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ASQPDLVDT(0.85)PT(0.117)S(0.029)S(0.003)KPQPK;ASQPDLVDT(0.612)PT(0.298)S(0.081)S(0.009)KPQPK 92.792 0.0067245 33399000.0 121842.0 135248.0 121047.0 115531.0 110604.0 100801.0 93468.0 104450.0 74489.0 139276.0 True False 115070.50941217119 145621.08670913696 113258.96780600873 99795.4784979085 96708.93670769446 114685.42276962771 97814.44720332835 104753.93220737153 89388.88139655678 135254.73999749342 0.8507687746418625 1.0766431306720612 0.8373752210688341 0.737833502173439 0.7150132905470573 0.8479216534056632 0.7231868340077477 0.774493612640214 0.6608927820068514 1.0 17.04531962857061 -5.483087584421409 6.430167257906558 0.7694389109521305 0.9637364075839601 0.33592347018438684 0.10137937839738671 0.19449741561032127 22.64440840479713 0.024738111754818597 0.050563498580164665 3.2878531786274253e-06 5.483087584421409 0.1942974966318296 ASQSRPNS(ph)SALETLGGEK ddPTM_A459_Selumetinib_30min_R1 2 ASQSRPNSSALETLGGEK 18 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 ASQSRPNS(0.958)S(0.041)ALETLGGEK;ASQSRPNS(0.937)S(0.059)ALET(0.004)LGGEK 196.83 1.2135e-09 16496400.0 3661.7 4671.8 4764.6 4952.7 3928.8 3861.3 3796.8 3772.0 2452.3 3210.5 True False 3747.0104855720992 4124.823484139102 4117.593490074403 4087.8039186932865 3573.4407336859767 3822.4588277798885 3510.4043191787837 3671.954306817227 4161.373991094506 3622.5989479182317 1.0343431716959346 1.1386365268254384 1.136640723765634 1.1284174642192701 0.986430125183881 1.0551703025189991 0.9690292438239894 1.0136242955978767 1.1487261082229066 1.0 11.822809380854604 -6.250281109005075 24.90658854076262 1.02783820297567 1.113527926659746 0.3477598530231064 0.0540070571067903 781.2776299805415 1743904.0659721005 0.015944084581367604 0.02040199150026554 5.619774521329929e-07 6.250281109005075 0.0856897236840759 ASQSRPNS(ph)SALETLGGEK ddPTM_A459_Selumetinib_30min_R2 2 ASQSRPNSSALETLGGEK 18 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 ASQSRPNS(0.971)S(0.029)ALETLGGEK;ASQS(0.001)RPNS(0.815)S(0.184)ALET(0.001)LGGEK 125.51 0.0039018 37258200.0 132348.0 125625.0 127486.0 135774.0 129099.0 114735.0 100578.0 111658.0 88643.0 130998.0 True False 124992.62799102123 135260.03355195886 119283.68955626168 117281.34697678572 112880.42946029651 130538.70478936963 105255.07629152616 111982.90629402304 106374.07689235985 127215.74736632063 0.9825248098500111 1.0632334152978289 0.9376487740372392 0.9219090356720652 0.8873149102780079 1.026120645374825 0.827374585855647 0.8802597839681413 0.8361706714346714 1.0 16.956917739722044 -5.434102602619356 4.228074389885649 0.9077291628914967 1.0220985478633384 0.3298410611178775 0.06235261871689832 0.2424053395737086 7.656749157406676 0.016549296568824715 0.03589574822064965 3.680420129806789e-06 5.434102602619356 0.11436938497184168 ASQSRPNSS(ph)ALETLGGEK ddPTM_A459_Selumetinib_30min_R1 1 ASQSRPNSSALETLGGEK 18 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 ASQSRPNS(0.293)S(0.704)ALET(0.004)LGGEK 201.22 6.675199999999999e-10 11997000.0 2400.7 2784.3 3171.7 2809.6 2557.4 2589.5 2639.0 2525.2 1170.3 1978.3 True False 2456.631639050969 2458.3128616140484 2741.0005609010186 2318.9561027238997 2326.083621545642 2563.451981077882 2439.938105328912 2458.2234929943966 1985.9136246698613 2232.2340752738323 1.1005260005044988 1.101279157434456 1.2279180715242755 1.0388498806691806 1.0420428786171527 1.1483795581623395 1.0930476030071354 1.101239121928932 0.889652947541465 1.0 11.124272602837395 -8.24695566053627 23.705471167524127 0.9448264944188575 1.1070454825032583 0.5701768176638159 0.05620348238537043 246.47397600305155 403406.5678170853 0.038454507954963524 0.0143625897146679 5.662971024094788e-09 8.24695566053627 0.16221898808440083 ASQTPVPPGAPS(ph)PDKDPAK ddPTM_A459_Selumetinib_30min_R2 2 ASQTPVPPGAPSPDKDPAK 19 1 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ASQTPVPPGAPS(1)PDKDPAK;ASQTPVPPGAPS(1)PDKDPAK 95.666 0.0009379 7483400.0 93607.0 74051.0 82715.0 68059.0 58826.0 55771.0 80717.0 76814.0 54743.0 59321.0 True False 88404.69767851068 79730.4735885063 77393.20695328282 58789.2467916764 51435.75196888748 63452.94901126886 84470.5004377012 77037.51602275774 65693.12964721913 57608.24859553207 1.5345840193684883 1.3840114138566253 1.3434396781728444 1.020500505134883 0.8928539440596132 1.1014559643493498 1.4662917637154564 1.3372653725968775 1.1403424205524988 1.0 15.813987777256385 -5.560201554521481 4.588371805301741 1.1531797034025077 1.4415531686446639 0.4048878101146076 0.160170926530185 0.2350380546505911 11.378507034879584 0.05002640329866693 0.09296387162251857 2.752950772175984e-06 5.560201554521481 0.2883734652421561 ASS(ph)ASVPAVGASAEGTR ddPTM_A459_Selumetinib_30min_R1 3 ASSASVPAVGASAEGTR 17 0 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 AS(0.064)S(0.848)AS(0.088)VPAVGASAEGTR;AS(0.079)S(0.841)AS(0.079)VPAVGASAEGTR;AS(0.015)S(0.985)ASVPAVGASAEGTR 236.31 2.275e-22 204555000.0 4668.8 5968.0 4560.4 4635.0 5677.9 4402.200000000001 5606.0 4541.799999999999 2835.62 4483.2 True False 4777.573956096629 5269.263785552069 3941.1227284840948 3825.5842597256783 5164.334947514662 4357.917864877793 5183.134906583509 4421.336710154426 4811.8400345094005 5058.662390066038 0.9444342372953378 1.0416318345141198 0.7790839602625954 0.7562442331075859 1.0208894267496758 0.861476320980753 1.0246058161070215 0.8740130036819295 0.9512079801883329 1.0 12.304540243034324 -6.308542136763551 24.999982029546526 0.9478336006269518 0.8846349305092218 0.1366439381662945 0.09095059701315401 1057.7380696690138 561395.8561894668 0.029563482201689015 0.03352192974009472 4.914256980529962e-07 6.308542136763551 -0.06319867011772995 ASS(ph)ASVPAVGASAEGTR ddPTM_A459_Selumetinib_30min_R2 2 ASSASVPAVGASAEGTR 17 0 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 AS(0.122)S(0.874)AS(0.004)VPAVGASAEGTR;AS(0.01)S(0.97)AS(0.02)VPAVGASAEGTR 145.94 0.00045253 28208000.0 166680.0 171990.0 219952.0 268490.0 303190.0 248000.0 173079.0 247524.0 245770.0 256570.0 True False 157416.59287290636 185181.07996498607 205800.52778563078 231921.19882891575 265100.56164700974 282159.7488801469 181127.51644953195 248244.25386019592 294930.8673875574 249162.15745108284 0.631783712596129 0.7432151088246298 0.8259702431980864 0.9308042649873428 1.0639679972230778 1.132434201752898 0.7269463320692754 0.9963160393204288 1.183690454460205 1.0 17.926725444069234 -5.459949958393221 1.3595159933100502 1.0081785775604728 0.6426413604491381 0.5677099804965264 0.1153957409142559 0.42497565917427477 1.3892908269648017 0.03864437374689109 0.15121372629334492 3.4677680552803496e-06 5.459949958393221 -0.3655372171113347 ASS(ph)ASVPAVGASAEGTRR ddPTM_A459_Selumetinib_30min_R1 2 ASSASVPAVGASAEGTRR 18 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 AS(0.001)S(0.937)AS(0.063)VPAVGASAEGTRR;ASS(1)ASVPAVGASAEGTRR 209.66 2.3489e-11 38162000.0 7091.7 5843.0 8814.1 8642.6 8147.299999999999 5955.700000000001 6695.1 5599.5 3819.3999999999996 4706.3 True False 7256.922811953918 5158.898843662994 7617.193632385683 7133.332151694753 7410.378153522646 5895.791065342936 6190.083216744064 5450.983070260626 6481.2428420610695 5310.399448244069 1.3665493307388552 0.9714709588124919 1.4343918393755437 1.343276004228543 1.3954464679625849 1.110234949894858 1.1656530317678588 1.0264732669146088 1.2204812284326652 1.0 12.374604669293456 -6.783505921626194 24.735739927254023 1.110040755396241 1.2934745723827816 0.3554519568122383 0.13271953165084235 265.374160179566 297471.8536029405 0.046911143478742076 0.041405631737809666 1.6462435195655275e-07 6.783505921626194 0.1834338169865406 ASS(ph)ASVPAVGASAEGTRR ddPTM_A459_Selumetinib_30min_R2 1 ASSASVPAVGASAEGTRR 18 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 AS(0.026)S(0.966)AS(0.003)VPAVGAS(0.004)AEGTRR 105.17 0.0031434 3678100.0 10727.0 10281.0 11131.0 13176.0 12220.0 6393.5 6131.6 7972.7 6005.5 14003.0 True False 10130.836283583323 11069.519641374645 10414.843578516457 11381.406070132218 10684.814351813913 7274.146590585559 6416.731549534899 7995.899237048467 7206.767807690023 13598.697005836648 0.7449858085105583 0.8140132570512849 0.7658706987916812 0.8369482800629535 0.785723393000662 0.5349149692403212 0.4718637047932458 0.5879901018175915 0.5299601722574473 1.0 13.731180802107788 -6.750338698038197 24.39092159895071 0.5896275503579271 0.7921921024321914 0.24023742834678385 0.13938170541635336 179.00707895795384 393321.4491510299 0.043202966108191 0.04279385196449214 1.7768931042657758e-07 6.750338698038197 0.20256455207426427 ASS(ph)CETYEYPQR ddPTM_A459_Selumetinib_30min_R1 1 ASSCETYEYPQR 12 0 Q9UQC2;Q9UQC2-2 Q9UQC2 GAB2 GRB2-associated-binding protein 2 1 AS(0.029)S(0.955)CET(0.015)YEYPQR 166.7 0.00045948 4646600.0 2604.1 3177.9 3063.9 3504.2 3076.7 2263.1 3207.9 2902.9 1491.5 2470.8 True False 2664.7704633034673 2805.8299906343727 2647.839208798004 2892.25725198074 2798.4130282355036 2240.3352687303936 2965.9255203048915 2825.9056620518923 2530.9665651500472 2787.9512476300793 0.9558167365977713 1.0064128607053267 0.9497437270643888 1.0374131378514337 1.0037524976860042 0.8035776345209799 1.0638369386215418 1.0136137295994958 0.9078231074885245 1.0 11.444989617956917 -10.675060405230607 4.490948346806514 1.0000041035978198 0.9736565187189224 0.01365286131932919 0.07065669361393263 2.8581306815686704e-06 5.396927345438963e-07 0.06735497273098902 0.016333436282650073 2.1131950989275052e-11 10.675060405230607 -0.026347584878897323 ASS(ph)CETYEYPQR ddPTM_A459_Selumetinib_30min_R2 1 ASSCETYEYPQR 12 0 Q9UQC2;Q9UQC2-2 Q9UQC2 GAB2 GRB2-associated-binding protein 2 1 AS(0.13)S(0.87)CETYEYPQR 157.03 0.00063067 0.0 9652.1 8661.8 13679.0 10582.0 11744.0 8470.6 9810.4 9176.5 10010.0 9399.9 True False 9115.674922417697 9326.132207923252 12798.908032569092 9140.713345031814 10268.613727307908 9637.34826154908 10266.603038938803 9203.202095748647 12012.279702768654 9128.500463126755 0.9985950002674738 1.0216499682061475 1.4020822022487058 1.0013378847878018 1.12489600770537 1.0557427586795598 1.124675742791409 1.0081833410562488 1.3159094148365884 1.0 13.156162173120274 ASS(ph)DGEGTMSR ddPTM_A459_Selumetinib_30min_R2 1 ASSDGEGTMSR 11 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 AS(0.02)S(0.805)DGEGT(0.175)MSR 116.03 0.0060073 12450000.0 18056.0 13093.0 17295.0 16798.0 21606.0 17218.0 18852.0 17159.0 21650.0 15484.0 True False 17052.519803894887 14097.190999369543 16182.258529372224 14510.083421833715 18891.66111990929 19589.623210557944 19728.65535452931 17208.929849174638 25980.604951542588 15036.936687736532 1.1340421362418966 0.9375041800147097 1.0761672317586977 0.9649627263289274 1.2563503798826594 1.30276688778868 1.3120129295097145 1.14444385891506 1.727785751251532 1.0 13.876223071861444 -6.359752179041636 4.641670714297435 1.3043406335004033 1.025595615762512 0.3381656185059496 0.18002539263013537 0.24916648846452677 8.91021110918171 0.05369871392698384 0.06133690067142733 4.3676499184717424e-07 6.359752179041636 -0.2787450177378914 ASS(ph)DGEGTMSRPASVDGSPVSPSTNR ddPTM_A459_Selumetinib_30min_R2 2 ASSDGEGTMSRPASVDGSPVSPSTNR 26 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 AS(0.152)S(0.788)DGEGT(0.056)MS(0.004)RPASVDGSPVSPSTNR;AS(0.243)S(0.738)DGEGT(0.009)MS(0.009)RPASVDGSPVSPSTNR 84.602 5.359600000000001e-05 25484000.0 14976.5 16575.5 19711.4 22882.0 22842.0 15502.1 17131.0 18382.1 15013.1 19567.5 True False 14144.166085679648 17846.787551367135 18443.189984149605 19765.432126348303 19972.38374992908 17637.37356094728 17927.62544443252 18435.58886767952 18016.139501062542 19002.535432529363 0.7443304676841729 0.9391792802983665 0.9705646938343687 1.040147100187114 1.0510378376003175 0.9281589619222527 0.9434333385714011 0.9701646884510305 0.9480913515478432 1.0 14.213904303995104 -4.723554118418326 2.5944060041346946 0.9813193006548692 0.6721999631265424 0.7781769227189892 0.03782016790813231 0.3133872825920611 2.376997784474607 0.010884263929639199 0.22810558080186974 1.889930707969676e-05 4.723554118418326 -0.30911933752832677 ASS(ph)EDTLNKPGSTAASGVVR ddPTM_A459_Selumetinib_30min_R1 2 ASSEDTLNKPGSTAASGVVR 20 1 Q5M775;Q5M775-2;J3KRD8;J3KRB9;J3KTI9;J3QRQ9;J3QS22 Q5M775 SPECC1 Cytospin-B 1 AS(0.145)S(0.855)EDTLNKPGSTAASGVVR;AS(0.021)S(0.977)EDT(0.001)LNKPGSTAASGVVR 146.67 0.0001115 36191000.0 2340.54 2442.42 2211.8900000000003 2370.6 2436.05 2287.8999999999996 2218.1 2300.67 1417.32 2127.79 True False 2395.0700281019535 2156.4603309497475 1911.5274870420767 1956.61921167329 2215.7097076195582 2264.8858032469902 2050.786931197444 2239.648757970625 2405.0885230428858 2400.9125729297416 0.9975665316206584 0.8981836137074752 0.7961670527259195 0.8149481300294507 0.9228614705098622 0.9433437222094417 0.8541697662464016 0.932832283533618 1.001739317857813 1.0 11.22936715474556 -8.095603810727871 3.177284163570552 1.0011975933559223 0.8868193847917221 0.37969905466878096 0.05616248124124462 0.29341755216500137 5.371680510858568 0.048000226187419254 0.016051655528390607 8.024097355132583e-09 8.095603810727871 -0.11437820856420022 ASS(ph)EDTLNKPGSTAASGVVR ddPTM_A459_Selumetinib_30min_R2 3 ASSEDTLNKPGSTAASGVVR 20 1 Q5M775;Q5M775-2;J3KRD8;J3KRB9;J3KTI9;J3QRQ9;J3QS22 Q5M775 SPECC1 Cytospin-B 1 AS(0.062)S(0.628)EDT(0.277)LNKPGS(0.005)T(0.019)AAS(0.008)GVVR;AS(0.06)S(0.936)EDT(0.003)LNKPGSTAASGVVR;AS(0.242)S(0.758)EDTLNKPGSTAASGVVR 79.455 0.002468 135664600.0 67162.0 61059.0 71980.0 67035.0 64647.0 56557.0 42317.5 48257.1 51894.0 71558.0 True False 63429.40491078798 65742.02896437074 67348.88516589842 57904.71735817502 56525.465908487226 64347.21337667128 44285.34760053548 48397.520171607015 62274.250039508166 69491.93460998783 0.9127592326616777 0.9460382608908094 0.9691611773925 0.8332580994205416 0.8134104515254497 0.9259666425724012 0.6372732008265388 0.6964480186546859 0.8961363701991066 1.0 16.084557924674925 -5.849833779055616 5.015086906692905 0.8097938044251017 0.942687652563605 0.19737364630049137 0.10076686079645426 0.29036892473003173 12.318230171296062 0.029049097414542025 0.04436247559569361 1.4130782797053126e-06 5.849833779055616 0.13289384813850325 ASS(ph)ESQGLGAGVR ddPTM_A459_Selumetinib_30min_R1 3 ASSESQGLGAGVR 13 0 Q9BV36-2;H7C2D8;Q9BV36-3 Q9BV36-2 MLPH Melanophilin 1 AS(0.145)S(0.854)ES(0.001)QGLGAGVR;AS(0.048)S(0.951)ESQGLGAGVR;AS(0.004)S(0.981)ES(0.015)QGLGAGVR 209.22 8.706900000000001e-06 68626000.0 7556.700000000001 8206.7 8649.400000000001 8619.0 8576.8 6906.6 8421.2 8864.5 4950.7 5707.2 True False 7732.756407221427 7245.85574880868 7474.858987753343 7113.8534486678855 7801.0299543570245 6837.125874691061 7785.982104052982 8629.384664045947 8400.976315178235 6439.774712835671 1.2007805788312131 1.1251722415640315 1.1607329947202276 1.1046742729196177 1.2113824321847964 1.0617026494829693 1.2090457277230628 1.3400134397319792 1.3045450640429275 1.0 12.652794503070318 -7.514126642991766 24.773257253802278 1.2482734698171465 1.1444185715100055 0.08363395212291413 0.09483742898552162 582.1159094859256 1647724.1738771244 0.03981074961542129 0.024474532420148444 3.061070676143472e-08 7.514126642991766 -0.10385489830714101 ASS(ph)ESQGLGAGVR ddPTM_A459_Selumetinib_30min_R2 4 ASSESQGLGAGVR 13 0 Q9BV36-2;H7C2D8;Q9BV36-3 Q9BV36-2 MLPH Melanophilin 1 AS(0.156)S(0.782)ES(0.062)QGLGAGVR;AS(0.034)S(0.943)ES(0.022)QGLGAGVR;AS(0.005)S(0.995)ESQGLGAGVR;AS(0.162)S(0.823)ES(0.015)QGLGAGVR 166.64 0.00032671 71714200.0 144604.0 113382.0 141697.0 148887.0 154182.0 141055.0 119793.0 132802.0 119008.0 167878.0 True False 136567.48857567649 122078.03481940835 132580.3692880286 128608.33375559894 134812.27875543156 160484.04588019795 125363.61186532635 133188.43183344536 142812.9253613475 163030.92594057316 0.8376784207522509 0.7488029287394672 0.8132222062969563 0.7888585126632864 0.8269123049977177 0.9843779329248025 0.7689560194918048 0.8169519437189128 0.8759867156333555 1.0 17.31478613502248 -14.522878743334806 0.14786822268997232 1.6116243796249308 0.7725526388034321 0.454339888708604 0.05944640741514408 130.44768473813622 1.1492475325706557 23.423019345778155 0.3240964141964021 3.0000000134392583e-15 14.522878743334806 -0.8390717408214987 ASS(ph)ESQIFELNK ddPTM_A459_Selumetinib_30min_R1 4 ASSESQIFELNK 12 0 Q9BV36;Q9BV36-4;H7C371 Q9BV36 MLPH Melanophilin 1 AS(0.001)S(0.998)ES(0.001)QIFELNK;AS(0.02)S(0.974)ES(0.006)QIFELNK;ASS(0.993)ES(0.007)QIFELNK;AS(0.001)S(0.98)ES(0.019)QIFELNK 316.65 4.1538e-84 233477000.0 25511.300000000003 27729.5 31555.899999999998 32377.0 28556.899999999998 25653.1 27544.5 27076.600000000002 18557.3 21396.4 True False 26105.663653651452 24482.91724890518 27270.782104151232 26722.96474156168 25973.93343713017 25395.053105151197 25466.796188795834 26358.440610807902 31490.38272843376 24142.836358585148 1.0813006088395378 1.014086202849944 1.1295599944889572 1.1068693149659294 1.075844322984606 1.0518670104857322 1.0548386200588187 1.0917706693329299 1.3043365021705844 1.0 14.559307556888719 -8.025056883821797 24.97530286529249 1.1674633718741312 1.0738547848602937 0.14182137569346542 0.07446342927408481 1110.4738044506387 1106851.0398707385 0.045864106524811855 0.01750956312342488 9.439372314409679e-09 8.025056883821797 -0.09360858701383745 ASS(ph)ESQIFELNK ddPTM_A459_Selumetinib_30min_R2 4 ASSESQIFELNK 12 0 Q9BV36;Q9BV36-4;H7C371 Q9BV36 MLPH Melanophilin 1 AS(0.001)S(0.983)ES(0.016)QIFELNK;AS(0.002)S(0.99)ES(0.008)QIFELNK;AS(0.007)S(0.987)ES(0.005)QIFELNK;AS(0.009)S(0.991)ESQIFELNK 278.93 5.6604e-44 126204000.0 558926.0 492501.0 534632.0 564790.0 545212.0 453175.0 434866.0 449214.0 384138.0 573374.0 True False 527863.1304780545 530274.2430596878 500234.3591833101 487864.6276829072 476717.59430287813 515595.7427369374 455088.13067063177 450521.1383686185 460976.33371250174 556819.2028154389 0.9479973531965599 0.952327506627767 0.8983784263437407 0.8761634390770336 0.8561443137960332 0.9259661666299156 0.8172996340097012 0.8090977036902703 0.8278743466131774 1.0 19.086849440165288 -5.459990332284466 1.5435376185946614 0.862479049436535 0.9574627751286974 0.22478180486743748 0.05408039326488383 0.5943576093536342 2.598265012443287 0.016355567849717763 0.05717025004014654 3.467445691565124e-06 5.459990332284466 0.0949837256921624 ASS(ph)FADMMGILK ddPTM_A459_Selumetinib_30min_R1 2 ASSFADMMGILK 12 0 E9PLD2;Q9H019-3;Q9H019;E9PPF9 E9PLD2 MTFR1L Mitochondrial fission regulator 1-like 1 ASS(1)FADMMGILK;ASS(1)FADMMGILK 270.93 8.3571e-34 120220000.0 12891.400000000001 15382.099999999999 15757.400000000001 16446.9 15584.099999999999 13684.7 15318.400000000001 13253.5 8224.7 11571.5 True False 13191.74453770221 13581.156581055719 13617.631629202548 13574.757661549571 14174.52090659633 13547.044342713458 14162.920755085415 12901.974126564724 13956.715191679234 13056.814740954935 1.0103340515603738 1.0401584804949477 1.0429520445356795 1.0396683977578405 1.0856032798057185 1.0375458801771027 1.0847148432504743 0.9881410116125393 1.068921897765893 1.0 13.672515368477434 -4.591364504703553 1.994230675870461 1.045756818411528 0.9841036522875761 0.09203437656231783 0.030281951649203182 3.387355625815395 9.316199689842312 0.007626333999674673 0.45705726068696756 2.5623325601210573e-05 4.591364504703553 -0.061653166123951886 ASS(ph)FADMMGILK ddPTM_A459_Selumetinib_30min_R2 1 ASSFADMMGILK 12 0 E9PLD2;Q9H019-3;Q9H019;E9PPF9 E9PLD2 MTFR1L Mitochondrial fission regulator 1-like 1 ASS(1)FADMMGILK 243.4 1.1757e-13 68081000.0 330120.0 323960.0 330510.0 422870.0 434720.0 304320.0 256810.0 282610.0 233900.0 320620.0 True False 311773.2519750655 348806.6903044181 309245.34643207974 365274.3765085616 380106.5871538908 346237.3176580903 268752.17385936086 283432.34831139597 280686.5357120469 311362.8675291966 1.0013180262923627 1.1202578299472732 0.9931991855229226 1.1731468797393116 1.220783294328596 1.1120058098309475 0.8631477991965752 0.910295921156425 0.901477231178592 1.0 18.24823737638193 -7.2534056542965955 24.52131055428421 0.9112548965428837 1.1077054776527024 0.6108395086982463 0.0720844776304363 313.2912712636531 956259.5313928191 0.029110924590466592 0.02213544990121563 5.579487972210515e-08 7.2534056542965955 0.19645058110981872 ASS(ph)FSGISILTR ddPTM_A459_Selumetinib_30min_R2 2 ASSFSGISILTR 12 0 A0A0U1RRA6;B5MCU0;B5MCG9;Q9Y2K5;H0YIX9;H7C0E9;Q9Y2K5-2;Q9Y2K5-3 A0A0U1RRA6;Q9Y2K5-3 R3HDM2 R3H domain-containing protein 2 1 AS(0.31)S(0.666)FS(0.025)GISILTR;AS(0.027)S(0.973)FSGISILTR 195.77 0.00010483 30886000.0 86036.0 60445.0 92469.0 104099.0 89954.0 56934.0 62751.0 76830.0 69516.0 74011.0 True False 81254.46354939634 65080.93713869186 86519.64521263502 89920.5366192086 78653.17432103674 64776.141704606016 65669.04583874751 77053.56258010885 83421.14243932713 71874.1101263284 1.1305108808523778 0.9054851186929948 1.2037664892207378 1.2510838250541283 1.0943185826272244 0.9012444340632982 0.9136676019129187 1.0720628393823153 1.160656351678 1.0 16.133184568590792 -6.544054034262153 24.76620998375353 1.0068992436749684 1.1204495744276823 0.19976777287323777 0.10867758862553319 387.0727662144534 452709.48636108486 0.03887359472168414 0.038876851796882 2.8572350284011517e-07 6.544054034262153 0.11355033075271392 ASS(ph)FSGISVLTR ddPTM_A459_Selumetinib_30min_R1 1 ASSFSGISVLTR 12 0 Q15032-2;Q15032-4;Q15032;Q15032-3;H7C207;H7C1X4;H7BZ47 Q15032-2 R3HDM1 R3H domain-containing protein 1 1 AS(0.011)S(0.966)FS(0.021)GIS(0.002)VLTR 84.352 0.032747000000000005 20504000.0 2310.6 2901.7 3398.7 3699.3 2864.1 2952.3 2644.9 2804.4 1642.4 2531.8 True False 2364.4324843550517 2561.9676150362666 2937.175207722763 3053.286699461319 2605.0426606979263 2922.602542473925 2445.393063578793 2730.0182020249836 2787.0328438501065 2856.781191820396 0.8276561366075046 0.8968021850506973 1.0281414677933869 1.0687856347568943 0.9118803596707884 1.0230403892471676 0.8559959266675727 0.955627336752859 0.9755849876882434 1.0 11.480174825464047 -5.011184123213825 4.297567308383513 0.973902811468073 0.8374024991648422 0.41090290508097316 0.057761578198363805 0.19400981536624726 8.794631583330663 0.015297634533469337 0.05714479809757997 9.745763693380223e-06 5.011184123213825 -0.1365003123032308 ASS(ph)FSGISVLTR ddPTM_A459_Selumetinib_30min_R2 2 ASSFSGISVLTR 12 0 Q15032-2;Q15032-4;Q15032;Q15032-3;H7C207;H7C1X4;H7BZ47 Q15032-2 R3HDM1 R3H domain-containing protein 1 1 AS(0.03)S(0.969)FS(0.001)GISVLTR;AS(0.008)S(0.875)FS(0.098)GIS(0.02)VLTR 166.7 0.00045948 9760600.0 30808.0 23333.0 35417.0 34722.0 35476.0 27425.0 29670.0 30304.0 24883.0 29348.0 True False 29095.814694195473 25122.56607257998 33138.30877911394 29992.80370120907 31019.187720536025 31202.544810637202 31049.71378998966 30392.17962290273 29860.295289110127 28500.646984738527 1.0208826034642529 0.8814735358826262 1.1627212812698176 1.0523551874899388 1.0883678443210822 1.0948012803830554 1.08943891016285 1.0663680596155265 1.0477058750666137 1.0 14.798707049391014 -5.257445028152019 24.997487540567175 1.0784502354225052 0.951178072937981 0.4929928090987623 0.05023158065312117 245.44487029893008 1536028.7377655215 0.011886730169433753 0.029148996431018828 5.527833733751015e-06 5.257445028152019 -0.12727216248452422 ASS(ph)HS(ph)SQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 3 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.031)S(0.954)HS(0.522)S(0.49)QT(0.003)QGGGSVTK;AS(0.071)S(0.927)HS(0.638)S(0.349)QT(0.016)QGGGSVTK;AS(0.017)S(0.983)HS(0.927)S(0.07)QT(0.003)QGGGSVTK 141.55 0.0072186 11100600.0 5211.76 5960.4 6311.3 6937.51 5549.7 5840.099999999999 6211.18 5505.44 3334.36 4376.71 True False 5333.183867680377 5262.553597085214 5454.260125489356 5726.004111691372 5047.730614879112 5781.353896386536 5742.665691950292 5359.41784701056 5658.165387981034 4938.503361265601 1.0799190518954371 1.0656170933002198 1.104435843512635 1.1594614183322043 1.0221174808688436 1.1706692237433116 1.16283522999944 1.085231183407981 1.1457247214530606 1.0 12.269858176588565 -5.350579572672659 5.278463789072299 1.1129443761513296 1.072988515749302 0.04600832727724469 0.05564430107917774 0.5544751075751524 24.767831913746853 0.014025564310375525 0.03025263211004715 4.4608788359945746e-06 5.350579572672659 -0.03995586040202759 ASS(ph)HS(ph)SQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 3 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.027)S(0.973)HS(0.572)S(0.265)QT(0.163)QGGGSVTK;AS(0.001)S(0.999)HS(0.782)S(0.218)QTQGGGSVTK;AS(0.013)S(0.987)HS(0.584)S(0.394)QT(0.022)QGGGSVTK 179.9 1.8959e-05 55819400.0 122735.0 108117.0 134342.0 159680.0 164940.0 108486.0 102745.0 117233.0 101064.0 142721.0 True False 115913.8800471333 116409.22624905167 125698.58198051008 137931.3085366358 144218.76261769125 123428.96176214356 107522.84608535511 117574.12862103201 121279.62396409681 138600.27389630902 0.836317828158492 0.8398917475166093 0.9069143836941398 0.9951734196414814 1.040537356553751 0.8905390898035629 0.7757765772223231 0.8482965099260389 0.875031632728444 1.0 17.0805705829109 -10.152049290276288 15.03706501226829 1.0000004784623289 0.891840138826248 0.16663500797692232 0.07378905151839203 0.0 0.0 0.08159779973274559 0.019790373359770977 7.046130943266859e-11 10.152049290276288 -0.10816033963608085 ASS(ph)HSS(ph)QTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 6 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.071)S(0.928)HS(0.141)S(0.798)QT(0.061)QGGGSVTK;AS(0.183)S(0.817)HS(0.328)S(0.671)QT(0.001)QGGGSVTK;AS(0.267)S(0.713)HS(0.026)S(0.993)QT(0.001)QGGGSVTK;AS(0.005)S(0.995)HS(0.003)S(0.994)QT(0.004)QGGGSVTK;AS(0.002)S(0.998)HS(0.243)S(0.642)QT(0.111)QGGGS(0.002)VTK;AS(0.097)S(0.902)HS(0.329)S(0.375)QT(0.297)QGGGSVTK 195.5 1.8309e-05 489192100.0 44223.950000000004 53354.6 48053.38 53237.9 57549.62 49062.0 56930.7 45720.5 16583.589999999997 33294.55 True False 45254.28199017294 47107.818628119385 41527.99493432222 43940.90016415311 52344.26703221063 48568.48082473179 52636.371463830495 44507.84381888574 28141.141012508648 37568.22980888053 1.2045891494061172 1.253927024716609 1.1054019618594235 1.1696292422531491 1.393312043141231 1.2928072755041276 1.4010873477831018 1.1847202821455483 0.7490675274206433 1.0 15.19722551825694 -8.138008238683604 5.351492435862733 0.88019839062262 1.2588513539568649 0.6832924234823321 0.10327483544621541 0.12813629970302803 4.924912016946258 0.07585367642637392 0.027517367678704642 7.2776599848834644e-09 8.138008238683604 0.3786529633342449 ASS(ph)HSS(ph)QTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 2 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.316)S(0.684)HS(0.102)S(0.725)QT(0.173)QGGGSVTK;AS(0.137)S(0.863)HS(0.017)S(0.982)QT(0.002)QGGGSVTK 145.79 0.006645300000000001 144650700.0 30551.0 25874.0 37134.0 40151.0 42449.0 29352.0 25029.5 27995.0 30311.0 40557.0 True False 28853.097725342985 27858.452601977202 34744.838868442195 34682.36453566168 37116.177121125096 33394.971569072884 26193.421345013343 28076.46081517827 36374.04696010197 39386.01403025898 0.732572168972877 0.7073184044614027 0.8821618466328905 0.8805756406072562 0.9423694688325139 0.8478890893456907 0.6650437214816863 0.7128535726821214 0.9235269893560945 1.0 15.265395799300247 -8.48617034129068 5.726819606390309 0.9997511222254329 0.8016584034533358 0.382537268796761 0.08656036648330269 0.19495332588117154 17.695491651730837 0.09395899775418101 0.024374697951274997 3.2645976127441655e-09 8.48617034129068 -0.1980927187720971 ASS(ph)HSSQT(ph)QGGGSVTK ddPTM_A459_Selumetinib_30min_R1 1 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.01)S(0.944)HS(0.006)S(0.094)QT(0.945)QGGGSVTK 158.65 0.011487 2519900.0 1036.0 1344.0 1103.7 1488.3 2030.1 1296.2 1650.4 1300.1 239.61 651.96 True False 1060.1367842949169 1186.643855191351 953.8236021901351 1228.396343851075 1846.4778134432647 1283.1614048554347 1525.9089992553372 1265.617124680032 406.6006695780104 735.6454166281792 1.4410975183588304 1.6130649744687011 1.2965806360379064 1.6698212427957657 2.51001062700366 1.7442661584663814 2.0742452338645982 1.7204173316011007 0.552712842882457 1.0 9.522866740108624 -8.250818769222956 23.11690198554169 0.7763564815099631 1.7705501261174772 0.5814911757103012 0.3332271964274202 165.0663646276058 359290.08917418955 0.2465254220900102 0.09065268685248713 5.6128214980893994e-09 8.250818769222956 0.9941936446075141 ASS(ph)HSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 1 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.142)S(0.584)HS(0.115)S(0.115)QT(0.044)QGGGSVTK 68.625 0.031318 15351000.0 1646.0 1991.5 2148.1 1723.1 1876.2 2034.5 1845.3 1976.0 1187.5 1454.5 True False 1684.3485974415373 1758.3342541767672 1856.3998186686872 1422.1929315929485 1706.4980412700133 2014.0347771782008 1706.1075353404472 1923.5900610474137 2015.1007684315648 1641.199243029768 1.0262913565156857 1.07137159710771 1.1311239793418646 0.8665571457171046 1.0397872461357582 1.2271726213205854 1.0395493067562314 1.1720637023304572 1.2278221410287447 1.0 10.680534678591176 -6.604486577568237 10.186632766011748 1.1380075147443391 1.0247281262370198 0.2512637241412047 0.09188871507638872 0.5258257998855213 61.62014946230066 0.030142022253712195 0.030133634186601272 2.4860703982567846e-07 6.604486577568237 -0.11327938850731933 ASS(ph)HSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 3 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.089)S(0.887)HS(0.005)S(0.018)QTQGGGSVTK;AS(0.125)S(0.775)HS(0.095)S(0.005)QTQGGGSVTK;AS(0.101)S(0.525)HS(0.365)S(0.009)QTQGGGSVTK 153.68 8.9923e-05 63532300.0 98095.0 71286.0 120635.0 183196.0 205944.0 122061.0 126466.0 182916.0 161106.0 245718.0 True False 92643.2726053981 76753.40697938252 112873.47543745686 158244.38876927266 180071.4735572803 138873.794790563 132346.91958762496 183448.2552766261 193331.70167774643 238623.48288796446 0.38824038390594956 0.3216506860534712 0.4730191432603128 0.6631551381871733 0.7546259545705534 0.5819787437088297 0.5546265521979781 0.7687770417916348 0.8101956242442289 1.0 17.864376499779098 -5.986268140901494 0.1778223203222931 1.0757501653854527 2.0302415722723135e-14 0.796382911176628 0.08927145501420541 5.57315014972693 0.2977717846048707 0.3870237433671864 1.4837934951981184 1.0321239578678967e-06 5.986268140901494 -1.0757501653854324 down ASS(ph)LEDLVLK ddPTM_A459_Selumetinib_30min_R1 6 ASSLEDLVLK 10 0 Q15477 Q15477 SKIV2L Helicase SKI2W 1 AS(0.008)S(0.992)LEDLVLK;AS(0.002)S(0.998)LEDLVLK;AS(0.004)S(0.996)LEDLVLK;AS(0.004)S(0.996)LEDLVLK;AS(0.001)S(0.999)LEDLVLK;AS(0.026)S(0.974)LEDLVLK 220.5 7.363899999999999e-05 472913000.0 76795.9 85183.8 92020.6 99344.1 83305.7 77222.5 80896.7 75731.9 42979.7 65843.1 True False 78585.09505119095 75210.44109512577 79524.70795297423 81995.51785471711 75770.7141438159 76445.71176242002 74794.59678869313 73723.24400011975 72933.41178691215 74294.70325110554 1.0577482863830074 1.012325748727001 1.0703953912325623 1.1036522694973814 1.0198669733927284 1.0289523804145817 1.0067285218960766 0.9923082100610277 0.9816771397606581 1.0 16.18097173882267 -7.012044134227684 1.4068800506162369 0.991390198502546 1.0564117222281795 0.5900470431722803 0.023412117911412275 0.32170576557275177 1.2923836064020853 0.013169863973391358 0.00957731927384274 9.726483754887455e-08 7.012044134227684 0.06502152372563352 ASS(ph)LEDLVLK ddPTM_A459_Selumetinib_30min_R2 15 ASSLEDLVLK 10 0 Q15477 Q15477 SKIV2L Helicase SKI2W 1 AS(0.03)S(0.97)LEDLVLK;AS(0.034)S(0.966)LEDLVLK;AS(0.003)S(0.997)LEDLVLK;AS(0.002)S(0.998)LEDLVLK;AS(0.002)S(0.998)LEDLVLK;AS(0.05)S(0.95)LEDLVLK;ASS(1)LEDLVLK;AS(0.002)S(0.998)LEDLVLK;AS(0.001)S(0.999)LEDLVLK;AS(0.003)S(0.997)LEDLVLK;ASS(1)LEDLVLK;AS(0.051)S(0.949)LEDLVLK;AS(0.058)S(0.942)LEDLVLK;AS(0.001)S(0.999)LEDLVLK;AS(0.002)S(0.998)LEDLVLK 234.9 1.2869e-06 163527350.0 1810627.5 1456810.5 1756083.2 1921714.0 1848185.2 1474616.7999999998 1529068.2 1601744.6 1325621.3 1631706.9000000001 True False 1710000.072066166 1568543.1809659402 1643098.7187908245 1659973.2380584478 1615999.652190676 1677731.878961477 1600172.9010911565 1606405.4116029085 1590782.6009538276 1584595.2821133328 1.0791399490888198 0.9898699047456557 1.036920112875426 1.0475692164402923 1.0198185432153124 1.0587762679211883 1.0098306609603485 1.0137638485585343 1.003904668220546 1.0 20.59568298126866 -7.402758099533337 9.00258137371976 1.0076572659517644 1.035915008483942 0.32211387202983444 0.022399601992258832 0.4446763154677091 30.99991768548177 0.008972328921661778 0.00603614117349799 3.955868991972043e-08 7.402758099533337 0.0282577425321775 ASS(ph)LGEIDESSELR ddPTM_A459_Selumetinib_30min_R1 2 ASSLGEIDESSELR 14 0 Q16513-3;Q16513-2;Q16513;Q16513-4;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 AS(0.061)S(0.939)LGEIDESSELR;AS(0.064)S(0.936)LGEIDESSELR 298.78 6.6548999999999975e-80 186281000.0 4772.2 5542.8 5686.5 6763.799999999999 5744.700000000001 4445.7 6075.4 5787.200000000001 2973.5 4116.7 True False 4883.382974915252 4893.846399222191 4914.3045337086205 5582.629302250822 5225.092899309162 4400.980294372633 5617.127686667401 5633.7046565251 5045.812324152638 4645.118545053726 1.0512935089924105 1.0535460724534833 1.0579502947113228 1.2018270896865244 1.124856739097221 0.9474419762782891 1.2092538935628891 1.2128225796355732 1.086261260119095 1.0 12.181499699823043 -5.567499795624039 24.999849582177443 1.1192901705255642 1.0532513961103098 0.08748803590535081 0.08279002866354807 287.06303956555377 160831.57594824635 0.022954827768254693 0.03975893778323112 2.7070744778514667e-06 5.567499795624039 -0.06603877441525441 ASS(ph)LGEIDESSELR ddPTM_A459_Selumetinib_30min_R2 3 ASSLGEIDESSELR 14 0 Q16513-3;Q16513-2;Q16513;Q16513-4;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 AS(0.128)S(0.872)LGEIDESSELR;AS(0.004)S(0.996)LGEIDESSELR;AS(0.131)S(0.869)LGEIDESSELR 253.06 9.7811e-28 132309000.0 148772.0 123663.0 150942.0 165981.0 177763.0 113200.0 130412.0 128902.0 117377.0 154106.0 True False 140503.8478215027 133147.55446078337 141230.55605322373 143374.1014668043 155430.82271861658 128792.2724727123 136476.41640647544 129277.08347912524 140855.6797874 149656.55936452618 0.9388418951906429 0.8896873951008657 0.9436977346861303 0.9580208316668608 1.0385834298116243 0.8605855501395454 0.9119307365208953 0.8638250406668672 0.941192824327269 1.0 17.19129598718721 ASS(ph)LNENVDHSALLK ddPTM_A459_Selumetinib_30min_R1 2 ASSLNENVDHSALLK 15 0 Q96SB3 Q96SB3 PPP1R9B Neurabin-2 1 AS(0.158)S(0.842)LNENVDHSALLK;AS(0.036)S(0.964)LNENVDHSALLK 183.31 2.0855e-05 10603400.0 2792.2 3398.3 3342.0 4036.4 3302.8 2784.3 3206.3 2797.7 1374.37 1914.18 True False 2857.2528273245794 3000.4254561731914 2888.174756291957 3331.5185126120264 3004.0623231567006 2756.2924699421314 2964.4462095930617 2723.4959077896506 2332.2055099867716 2159.8836486921423 1.322873493234096 1.389160688350049 1.3371899722657796 1.5424527680596753 1.3908445137661594 1.2761300691410522 1.3725027324449166 1.2609456576231726 1.0797829371035677 1.0 11.076737882247128 -8.198512125545259 1.3477144575106705 0.9927384339512729 1.3854014320180612 0.8089089951938454 0.0652290973243547 0.1773830222607303 0.6085881313046648 0.06336780219279155 0.02016081087752761 6.33122684615531e-09 8.198512125545259 0.3926629980667883 ASS(ph)LNFLNK ddPTM_A459_Selumetinib_30min_R1 2 ASSLNFLNK 9 0 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 ASS(1)LNFLNK;AS(0.001)S(0.999)LNFLNK 201.09 0.0016517 1066660000.0 13678.0 15534.800000000001 17649.199999999997 18048.8 15960.6 12662.7 15412.0 13546.3 7873.7 11588.7 True False 13996.670787245052 13715.978394067419 15252.535580116093 14896.915897936753 14516.966548072796 12535.3247348117 14249.460431727619 13187.008119416276 13361.093827704937 13076.222528497117 1.0703909907270233 1.0489251283523262 1.1664328552742291 1.1392369520686716 1.110180445188651 0.958635011563421 1.0897229991821915 1.0084722931777677 1.0217854428973656 1.0 13.674658213467138 -6.731437461902916 24.690848647262595 1.0208776634808063 1.1088941811946218 0.5277663929198112 0.0430305083058539 155.62749283965832 128077.20068897949 0.014628363978038773 0.014626386908708206 1.855934043377066e-07 6.731437461902916 0.08801651771381547 ASS(ph)LNFLNK ddPTM_A459_Selumetinib_30min_R2 2 ASSLNFLNK 9 0 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 AS(0.003)S(0.997)LNFLNK;ASS(1)LNFLNK 172.21 0.00051016 612350000.0 252500.0 213730.0 265240.0 278650.0 255640.0 179935.0 218303.0 204194.0 186713.0 227877.0 True False 238467.0608375861 230122.40374973265 248174.74717147622 240697.38930193867 223524.21774940315 204719.41296269876 228454.52205918802 204788.17073386375 224060.8171971077 221297.59891444957 1.0775853963502513 1.0398775444404826 1.121452507342463 1.0876638087473727 1.0100616493169199 0.9250864626047763 1.0323407175669592 0.9253971653485128 1.0124864358954313 1.0 17.75562827237642 -6.389717305975906 4.003438151801465 0.9769024639795099 1.0812665299233233 0.6293342264578996 0.03710621716978168 0.14604818983740292 4.013834773878029 0.011355205492763453 0.012928166821238934 4.076455389683105e-07 6.389717305975906 0.10436406594381342 ASS(ph)LNVLNVGGK ddPTM_A459_Selumetinib_30min_R1 2 ASSLNVLNVGGK 12 0 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 AS(0.009)S(0.991)LNVLNVGGK;ASS(1)LNVLNVGGK 191.19 0.00013335 1522490000.0 13833.0 15786.7 15673.199999999999 16518.3 14891.2 12314.0 14522.400000000001 12763.9 7896.1 10655.599999999999 True False 14155.281985667547 13938.385824962274 13544.86552672505 13633.688991893572 13544.293589254892 12190.13234021743 13426.963675948678 12425.359909009656 13399.104991673668 12023.350054333441 1.1773159661575117 1.1592763881925419 1.1265467166401952 1.1339342970372666 1.1264991477457045 1.0138715320713694 1.116740643437338 1.0334357606540219 1.1144235950149666 1.0 13.553551308326426 -1.5228787453745556 0.13266344592660384 0.9852570180730809 1.6496768573961322 0.6211984948883027 0.036091181636871146 51.72773811688646 0.46420895017662184 0.17557828723818206 6.448376031022207 0.02999999999349165 1.5228787453745556 0.6644198393230514 ASS(ph)LNVLNVGGK ddPTM_A459_Selumetinib_30min_R2 4 ASSLNVLNVGGK 12 0 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 AS(0.03)S(0.97)LNVLNVGGK;AS(0.226)S(0.774)LNVLNVGGK;AS(0.001)S(0.999)LNVLNVGGK;AS(0.005)S(0.995)LNVLNVGGK 180.95 0.00010379 1220236500.0 470953.0 450878.0 526984.0 520892.0 519412.0 411608.0 433274.0 441580.0 388407.0 405599.0 True False 444779.31763423275 485458.89279872837 493078.4231767966 449945.61101118056 454158.82095780375 468303.2657945944 453422.099516143 442864.92469249596 466099.2529983275 393888.30299723946 1.1292016397789553 1.2324785709671877 1.251822964593727 1.1423177778760645 1.1530142365283356 1.188924022955504 1.1511438549098543 1.124341396590291 1.1833284955445709 1.0 18.58742704940238 -14.522878745059074 0.18782688776471398 0.2529478896628089 1.2065493678684172 0.6420630990810786 0.0392940844778548 85.49889219233629 0.8312505456242898 23.82010347191614 0.11166888947854683 3.000000001528432e-15 14.522878745059074 0.9536014782056083 ASS(ph)LPGSLQR ddPTM_A459_Selumetinib_30min_R1 1 ASSLPGSLQR 10 0 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 AS(0.153)S(0.843)LPGS(0.004)LQR 106.16 0.012072 14577000.0 3042.6 3297.5 3494.1 4281.2 3369.8 3057.6 3598.2 3121.3 1507.8 2844.9 True False 3113.4866601309973 2911.4271670338403 3019.6204117174534 3533.5687880771493 3065.002184986511 3026.843320078676 3326.784877072561 3038.5129845887095 2558.626474645149 3210.07062667266 0.9699121988970768 0.9069667012440865 0.9406710203281059 1.1007760261461303 0.9548083333491896 0.942921098037053 1.0363587795951015 0.9465564275569303 0.7970623616145313 1.0 11.648389323950317 -10.221692575608182 5.308918393047245 1.0000000038191115 0.95932815372 0.028715852450370005 0.0747836712274121 104056190.48863648 16.33550896830651 6.4473682125699945 0.01839546473429957 6.002158011650301e-11 10.221692575608182 -0.04067185009911145 ASS(ph)LPPIVGSR ddPTM_A459_Selumetinib_30min_R1 1 ASSLPPIVGSR 11 0 Q9UHG0 Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 1 AS(0.008)S(0.992)LPPIVGSR 86.463 0.033429 6628300.0 2404.8 3030.1 2907.4 3121.8 3160.5 2637.4 2506.4 2509.7 1537.8 2292.9 True False 2460.8271610737597 2675.3344833447286 2512.5910492050375 2576.636233443718 2874.6333330315933 2610.8701505676026 2317.3402300857842 2443.134603345493 2609.5342835318397 2587.2160497373366 0.951148691785362 1.0340591709054752 0.9711562547936902 0.9959107333557657 1.111091334379839 1.009142684791503 0.8956887192784109 0.94431023786882 1.0086263510141602 1.0 11.337184818340722 -7.0366045170023455 24.879906247437148 0.9567869511393297 1.0155729403065552 0.19289173353289724 0.049415367793424 832.3192153349815 565720.8620252053 0.019306682602976025 0.014960265765277864 9.191692415656281e-08 7.0366045170023455 0.05878598916722555 ASS(ph)MPATLLHSR ddPTM_A459_Selumetinib_30min_R2 1 ASSMPATLLHSR 12 0 Q5T7N3 Q5T7N3 KANK4 KN motif and ankyrin repeat domain-containing protein 4 1 AS(0.187)S(0.813)MPATLLHSR 179.65 6.8727e-05 2316400.0 27665.0 18966.0 26404.0 25798.0 26332.0 13779.0 15813.0 14461.0 10105.0 14446.0 True False 26127.490051769608 20420.63121469813 24705.19538650155 22284.267895967736 23023.938748933215 15676.932176691716 16548.335832865054 14503.07911585257 12126.282357290427 14028.906444784408 1.8624038983083493 1.45561104816477 1.7610207526678827 1.5884536676949943 1.6411784367906261 1.1174735706160477 1.1795884374877492 1.0337996887308667 0.8643783038270008 1.0 13.776114934610288 -6.8659589788232775 1.5526022144054574 0.9945214176568226 1.6744333062669583 0.856061146068904 0.12729249751727734 0.13523570255650347 0.6731012238765346 0.05648168727970944 0.047062399125126664 1.3615732834564875e-07 6.8659589788232775 0.6799118886101357 ASS(ph)PAESS(ph)PEDSGYMR ddPTM_A459_Selumetinib_30min_R2 1 ASSPAESSPEDSGYMR 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 2 AS(0.08)S(0.92)PAES(0.082)S(0.901)PEDS(0.016)GYMR 146.27 0.006392 2934600.0 22353.0 13027.0 18837.0 21483.0 21364.0 13792.0 15092.0 17677.0 14069.0 15607.0 True False 21110.709746148783 14026.129011592999 17625.047928174867 18556.978339757927 18680.063323416725 15691.722808689472 15793.807904230664 17728.437143415107 16883.1931207045 15156.385358144154 1.392859131468647 0.9254270513817583 1.1628793747121373 1.224367017679878 1.2324880162392515 1.0353209184047079 1.042056369709813 1.169700870259866 1.1139326905298341 1.0 13.887638106167179 -6.766409359681421 24.988823789272672 1.0809243638494646 1.1737075121640759 0.19145762280219958 0.11615480533714516 269.47342868334346 1354887.6903045303 0.039963153496533455 0.03633303691139619 1.7123425173610024e-07 6.766409359681421 0.09278314831461132 ASS(ph)PAESSPEDSGYMR ddPTM_A459_Selumetinib_30min_R2 1 ASSPAESSPEDSGYMR 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 AS(0.134)S(0.837)PAES(0.027)S(0.002)PEDSGYMR 217.19 1.2934000000000002e-10 9518300.0 24965.0 24414.0 25004.0 23614.0 27897.0 18833.0 19295.0 21921.0 17079.0 23465.0 True False 23577.545242813238 26286.475296617125 23395.26986229678 20397.732463577882 24392.329457655713 21427.074801047605 20192.255732317168 21984.786480783107 20495.277227131453 22787.504480608208 1.0346699114366533 1.1535477840053299 1.0266709934036775 0.8951279628243636 1.0704256571145465 0.9402993126905008 0.886110883686296 0.9647737644765708 0.8994085879203051 1.0 14.475955319484758 -5.531273421224214 6.379252703869911 0.9516021758172211 1.093757555882119 0.4968196344843805 0.05835661758417721 0.10911182286903202 19.679845778684996 0.015472632956741311 0.02852578108103861 2.942568481090109e-06 5.531273421224214 0.14215538006489803 ASS(ph)PAQCVTPVQTVV ddPTM_A459_Selumetinib_30min_R2 1 ASSPAQCVTPVQTVV 15 0 Q13614;Q13614-2 Q13614 MTMR2 Myotubularin-related protein 2 1 AS(0.348)S(0.651)PAQCVT(0.001)PVQTVV 86.539 0.019583 3402300.0 15650.0 13899.0 18276.0 16867.0 20255.0 14444.0 14520.0 12811.0 10479.0 14115.0 True False 14780.235651913772 14965.008607671067 17100.142057404257 14569.685502802076 17710.385818002527 16433.529890422757 15195.20877083416 12848.277889024788 12575.092807723538 13707.463274825703 1.0782619187503686 1.0917416525313546 1.2475059545707003 1.062901662451278 1.2920250423379467 1.1988746247895177 1.1085354354908805 0.9373198841700461 0.9173902242596698 1.0 13.742673987906189 -7.670853339703854 3.840621140417073 0.9440813087106867 1.1633354364911133 0.6305521591234148 0.07186210916000559 0.14291557876843422 3.998344175704024 0.03806252352947439 0.02018128261911602 2.13376535938559e-08 7.670853339703854 0.21925412778042652 ASS(ph)PCHSPR ddPTM_A459_Selumetinib_30min_R2 2 ASSPCHSPR 9 0 A0A494BYR6;Q86Y91-6;Q86Y91 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 1 AS(0.117)S(0.876)PCHS(0.007)PR;AS(0.008)S(0.988)PCHS(0.003)PR 120.63 0.0065183 3480600.0 6444.8 4769.76 4859.4 5508.7 5614.3 8357.9 18868.4 55884.0 13955.099999999999 28322.0 True False 6086.623816578521 5135.585254804311 4546.751494514677 4758.405556962459 4908.98144152118 9509.124859537818 19745.817987025315 56046.613187905794 16746.509938072606 27504.270270606696 0.22129741151806462 0.18671956042740812 0.1653107481049481 0.17300606451819514 0.1784807011137946 0.34573267227162335 0.7179182647913152 2.037742235532123 0.6088694509364712 1.0 14.74736800618502 -7.43986576639578 3.532692448064367 1.2625901408954219 0.20716690967161452 0.6304519391601117 0.34148848561025624 0.13738148720732665 3.252822553960639 0.14797139004573848 0.09188838254631972 3.6319029383984674e-08 7.43986576639578 -1.0554232312238074 ASS(ph)PCPEFEQFQIVPAVETPYLAR ddPTM_A459_Selumetinib_30min_R1 2 ASSPCPEFEQFQIVPAVETPYLAR 24 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 AS(0.218)S(0.782)PCPEFEQFQIVPAVETPYLAR;AS(0.029)S(0.971)PCPEFEQFQIVPAVETPYLAR 222.92 7.708899999999998e-35 13673000.0 2290.31 2340.5699999999997 2963.5 3112.8 2427.71 2683.12 2300.52 2358.93 1431.0 1937.13 True False 2343.6697668325196 2066.5349762985275 2561.072977340281 2569.2079144927943 2208.1240591470123 2656.13024887804 2126.9899242407214 2296.3635135154736 2428.3024838952156 2185.7795047440736 1.0722352194014797 0.9454453076411712 1.171697772708391 1.175419528326859 1.0102226937138177 1.2151867300032344 0.9731036088609333 1.0505924813236585 1.110954914997036 1.0 11.093932158015631 -9.70292438961738 8.066942536443436 0.9999917491687043 1.0798894968818633 0.07488544872269698 0.08489639593627842 0.0 0.0 0.08125271413638263 0.019706677808966053 1.9818720383846393e-10 9.70292438961738 0.07989774771315905 ASS(ph)PCPEFEQFQIVPAVETPYLAR ddPTM_A459_Selumetinib_30min_R2 1 ASSPCPEFEQFQIVPAVETPYLAR 24 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 AS(0.044)S(0.956)PCPEFEQFQIVPAVETPYLAR 173.99 1.0852e-16 9118000.0 18254.0 14385.0 13754.0 16053.0 18986.0 11764.0 12893.0 11921.0 13833.0 13526.0 True False 17239.515756551697 15488.283244934757 12869.082614222933 13866.5537070304 16600.808943006457 13384.384217040524 13492.550046994826 11955.688136372211 16599.98652631356 13135.469235231487 1.3124400390899231 1.179119144323572 0.979720052916415 1.0556572786785587 1.2638154485170854 1.018949835544619 1.027184473228074 0.910183558902113 1.2637528381391714 1.0 13.681180117992051 -4.955593418205014 3.5987709105848675 1.065526989686949 1.3065020155056675 0.33713047142269714 0.1090390865650361 0.2712313090639583 6.991556699183822 0.02761735356162867 0.13832247758479108 1.1076602782924758e-05 4.955593418205014 0.24097502581871844 ASS(ph)PEKAEEDR ddPTM_A459_Selumetinib_30min_R1 3 ASSPEKAEEDR 11 1 Q8N3D4;H0YDZ9 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 AS(0.123)S(0.877)PEKAEEDR;AS(0.023)S(0.977)PEKAEEDR;AS(0.022)S(0.978)PEKAEEDR 139.74 0.0054271 77928500.0 17929.6 21550.5 23644.8 23493.4 18599.3 20476.6 18950.1 19734.9 12709.5 17293.0 True False 18347.32479507156 19027.357441444365 20433.9660315895 19390.71871573664 16916.996598973124 20270.62399526525 17520.678700186952 19211.466344010423 21567.093234847154 19512.724998084406 0.9402748615005205 0.9751255882155009 1.0472123208621829 0.9937473478276486 0.8669725320596632 1.0388412688261248 0.897910399593444 0.9845609132448924 1.105283513039026 1.0 14.252127647332344 -8.078624384761754 7.940782926695805 1.0511074147841353 0.9673539982586028 0.2596484152423173 0.05781726614862599 0.4337430408620243 39.466016535054294 0.03833395306178398 0.01442034173484306 8.344025357432255e-09 8.078624384761754 -0.08375341652553248 ASS(ph)PEKAEEDR ddPTM_A459_Selumetinib_30min_R2 1 ASSPEKAEEDR 11 1 Q8N3D4;H0YDZ9 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 AS(0.099)S(0.901)PEKAEEDR 149.32 0.0030059 7927900.0 24362.0 18799.0 20967.0 20134.0 15703.0 12368.0 17101.0 17229.0 12856.0 15206.0 True False 23008.057568812987 20240.822851687775 19618.006047143528 17391.71446691272 13730.248753398844 14071.579734474435 17896.23038498864 17279.133537585512 15427.55922665273 14766.96327006727 1.558076440499481 1.3706828195825511 1.3285064564973459 1.1777448178642007 0.9297950094607567 0.9529095100410806 1.211909995148726 1.1701209802973118 1.0447347192854803 1.0 13.850085555303242 -5.579613846986306 1.5781920862726213 1.0633083858677799 1.4913644499315468 0.7667721972590544 0.09252213041935638 0.22168081399553433 1.070738024942639 0.031789545120318216 0.09016732736228376 2.632607735172693e-06 5.579613846986306 0.42805606406376695 ASS(ph)PFR ddPTM_A459_Selumetinib_30min_R1 1 ASSPFR 6 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 AS(0.04)S(0.96)PFR 115.46 0.024021 76488000.0 2612.3 4258.4 2526.2 2599.1 2868.4 2921.6 3266.6 2898.6 1792.7 2745.1 True False 2673.1615073490434 3759.824548323549 2183.1559154233214 2145.2159761495172 2608.9537264571527 2892.2113566005564 3020.1977320452515 2821.71971202026 3042.0809663724353 3097.4603245383387 0.8630171906229227 1.2138410679671685 0.7048212686142187 0.6925725437562308 0.842288020863029 0.9337363690143881 0.9750561478121265 0.9109784844268581 0.9821210435765122 1.0 11.596870087622516 -6.89770394841577 4.880168884372853 0.9589351902744429 0.864890709610902 0.11665081246517717 0.13507581439486305 0.5900892204516446 23.196562152023972 0.052621403359995586 0.04624271217420412 1.2655987918825416e-07 6.89770394841577 -0.09404448066354087 ASS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 2 ASSPFR 6 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 AS(0.045)S(0.955)PFR;AS(0.043)S(0.957)PFR 111.65 0.025184 757400000.0 238513.0 221834.0 208455.0 231972.0 279150.0 204982.0 332510.0 418650.0 302660.0 338020.0 True False 225257.40230318898 238847.95449126558 195043.23224864338 200377.01342597947 244080.68136733663 233216.40985867055 347972.3738560657 419868.20218876103 363200.4570269693 328260.48431856773 0.6862154083845892 0.7276171391359743 0.594172133309105 0.6104207572895649 0.7435579152148666 0.7104614201212853 1.0600495352902974 1.2790701965250577 1.1064397768769916 1.0 18.324481564558333 -7.291963748308448 3.265680132382463 1.1496405601723731 0.6716469197216527 0.8826334538415672 0.07751132209303663 0.07562441940710174 1.6628113298291611 0.03421463728469031 0.022993046309969685 5.105476149359629e-08 7.291963748308448 -0.47799364045072046 ASS(ph)PFRR ddPTM_A459_Selumetinib_30min_R1 2 ASSPFRR 7 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 ASS(1)PFRR;AS(0.005)S(0.995)PFRR 101.72 0.023003 298957000.0 15081.3 15905.7 17552.9 19112.5 18157.3 15894.6 14215.0 13853.9 9570.9 12296.4 True False 15432.66494689857 14043.453249640688 15169.31259117807 15774.860661058707 16514.975420931685 15734.714755142102 13142.75110543785 13486.449568190661 16241.118269121402 13874.762717078884 1.112283161996134 1.0121580841418036 1.0933024874368253 1.1369463379464453 1.1902888544971568 1.1340528898396038 0.9472415041202847 0.9720129881277007 1.1705510645691761 1.0 13.760175478592679 -7.239358755609618 24.576028100477235 1.0201191267421459 1.112263241785112 0.29034894393106947 0.06943521856164254 883.2015923207654 983016.3562352055 0.027979548736611383 0.021652300513714938 5.762902133537357e-08 7.239358755609618 0.09214411504296605 ASS(ph)PGYIDSPTYSR ddPTM_A459_Selumetinib_30min_R1 1 ASSPGYIDSPTYSR 14 0 A0A0C4DGA7;O94929-3;O94929-2;O94929 A0A0C4DGA7 ABLIM3 Actin-binding LIM protein 3 1 AS(0.001)S(0.999)PGYIDSPTYSR 206.46 7.5625e-06 10292000.0 2581.7 2530.3 2556.0 2637.8 2539.8 1880.9 2316.0 2069.5 1425.7 2061.1 True False 2641.8485868862804 2234.0512996954444 2208.9092391030063 2177.1577476384887 2310.075538438111 1861.9798537205586 2141.3022553777014 2014.6101373166111 2419.3087709919 2325.6622618141296 1.1359553922612606 0.9606086560276279 0.9497979458891636 0.9361452792978633 0.9932979419961606 0.8006234973551679 0.9207279537259128 0.8662522372208583 1.0402665987729112 1.0 11.183425885091363 ASS(ph)PGYIDSPTYSR ddPTM_A459_Selumetinib_30min_R2 2 ASSPGYIDSPTYSR 14 0 A0A0C4DGA7;O94929-3;O94929-2;O94929 A0A0C4DGA7 ABLIM3 Actin-binding LIM protein 3 1 AS(0.008)S(0.992)PGYIDSPTYSR;ASS(1)PGYIDSPTYSR 203.74 3.1855e-05 39328000.0 190671.0 176786.0 186587.0 202126.0 213140.0 127829.0 132878.0 147427.0 128170.0 163142.0 True False 180074.2691364888 190344.91774341543 174582.19556056528 174596.09011320185 186363.44770422397 145436.28443387232 139057.09029276177 147855.98816214624 153807.58136901664 158431.66656617867 1.1366052825132011 1.2014322759390166 1.1019400309573866 1.1020277315600358 1.1763017567348375 0.9179748442090772 0.8777102034376194 0.9332476983090067 0.9708133777963479 1.0 17.273501197682705 -6.764777650217469 24.99992554743015 0.9318872357557375 1.1422400831244228 0.8572373235176918 0.04149935152270779 30.63964695425196 229455.14595407058 0.014653808819257883 0.013450992374053627 1.7187881458718877e-07 6.764777650217469 0.21035284736868531 ASS(ph)PHGLGSPLVASPR ddPTM_A459_Selumetinib_30min_R1 1 ASSPHGLGSPLVASPR 16 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 AS(0.06)S(0.926)PHGLGS(0.014)PLVASPR 94.45 0.0092252 3287600.0 1195.4 1731.4 1623.1 2297.2 1810.5 1634.5 1473.6 1654.2 907.14 1185.2 True False 1223.2504941565087 1528.6868830939777 1402.6919350501116 1896.0371437846447 1646.7405946697374 1618.05841400726 1362.4451655978332 1610.3252424011284 1539.3503251157977 1337.3319648256313 0.914694725266664 1.143087074340062 1.0488734076082615 1.417775985061316 1.2313626219832774 1.2099153064199966 1.0187785841008268 1.204132769391399 1.1510607430343645 1.0 10.385141913564789 -12.186074728685169 1.2179700319310085 9.507372320593867e-05 1.155680033972514 0.1040426030142898 0.12965906756467127 160678.78617389753 8406.637040434503 437762.11659006233 0.0392021913275066 6.515162785588192e-13 12.186074728685169 1.155584960249308 ASS(ph)PHGLGSPLVASPR ddPTM_A459_Selumetinib_30min_R2 2 ASSPHGLGSPLVASPR 16 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 AS(0.137)S(0.863)PHGLGSPLVASPR;AS(0.156)S(0.844)PHGLGSPLVASPR 97.214 0.0051217 7029100.0 30506.0 29799.0 30596.0 26246.0 25347.0 20002.8 22866.0 22199.7 20964.4 23027.0 True False 28810.598645193702 32084.487481113043 28627.486670406055 22671.24952312464 22162.68325494495 22758.004132660502 23929.314308119418 22264.297451641836 25157.865794278026 22362.150678668884 1.2883643912066094 1.4347675204477641 1.2801759133889405 1.0138224113099552 0.9910801323812649 1.017701940197068 1.0700810781561114 0.9956241584974029 1.125019956970237 1.0 14.448771325523076 -5.672823171924824 4.027878551176395 1.0292463232952498 1.3604731217570398 0.8821188660652372 0.05136311742818563 0.06186777176973572 1.8771497029036686 0.013616132007246274 0.024325513578172094 2.1241091418237914e-06 5.672823171924824 0.33122679846179004 ASS(ph)PNLHR ddPTM_A459_Selumetinib_30min_R2 1 ASSPNLHR 8 0 A0A087X030;P51956-2;P51956;A0A087WY58 A0A087X030 NEK3 Serine/threonine-protein kinase Nek3 1 AS(0.037)S(0.963)PNLHR 88.056 0.031604 4148800.0 19862.0 15423.0 15552.0 22642.0 19258.0 18767.0 20894.0 22957.0 17910.0 21979.0 True False 18758.149553885698 16605.894507238718 14551.401251737303 19558.120540371416 16838.637871295607 21351.983900135947 21865.612400675556 23023.80106926406 21492.50044721144 21344.409161699892 0.878831988825676 0.7779973847688463 0.6817429867231056 0.9163111703961444 0.7889015687307298 1.0003548816169456 1.0244187241271079 1.0786806462920344 1.0069381768494807 1.0 14.381570607195524 -6.811633601372048 4.70496785074681 1.030871667829133 0.805333309164782 0.7483742379144055 0.06186751293899446 0.10146450645332938 4.753961339588754 0.022386347109593252 0.020132127195740226 1.543001678971112e-07 6.811633601372048 -0.225538358664351 ASS(ph)PPDRIDIFGR ddPTM_A459_Selumetinib_30min_R1 3 ASSPPDRIDIFGR 13 1 Q9NWB6-2;Q9NWB6 Q9NWB6-2 ARGLU1 Arginine and glutamate-rich protein 1 1 AS(0.157)S(0.843)PPDRIDIFGR;AS(0.017)S(0.983)PPDRIDIFGR;AS(0.012)S(0.988)PPDRIDIFGR 140.63 0.00047932 1145490000.0 13108.2 13112.0 21876.1 24855.199999999997 18734.3 14220.2 14626.1 13735.1 8804.900000000001 9942.8 True False 13413.595555882848 11576.840944396572 18905.445776815825 20514.705909888602 17039.78587280931 14077.157698908557 13522.841501459343 13370.800530107457 14941.272215547875 11219.055231073471 1.1956083003077789 1.031890895084654 1.6851192357493099 1.8285591333099889 1.5188253842992172 1.2547542916019332 1.2053458355392586 1.1917938056917918 1.3317763312337532 1.0 13.453663569682082 -6.864035618503761 5.053158449332029 1.2029550373570144 1.461848286421009 0.24660042066630738 0.22402504856187244 0.3675065151857913 15.049636538728876 0.0902379558023223 0.0797516027873699 1.3676166564141707e-07 6.864035618503761 0.2588932490639946 ASS(ph)PPDRIDIFGR ddPTM_A459_Selumetinib_30min_R2 3 ASSPPDRIDIFGR 13 1 Q9NWB6-2;Q9NWB6 Q9NWB6-2 ARGLU1 Arginine and glutamate-rich protein 1 1 AS(0.1)S(0.9)PPDRIDIFGR;AS(0.212)S(0.788)PPDRIDIFGR;AS(0.204)S(0.796)PPDRIDIFGR 73.758 0.027986 599914000.0 88962.0 131676.0 123743.0 115925.0 132953.0 86766.0 58019.3 56190.0 53780.0 116047.0 True False 84017.84818310235 141775.12579492712 115781.5101011912 100135.8150182209 116250.25552509955 98717.22891667267 60717.31241306194 56353.50359724475 64537.50273875102 112696.42158368391 0.7455236555201002 1.2580268636981566 1.0273752127543503 0.8885447613246886 1.0315345766216428 0.8759570847896813 0.5387687697605879 0.5000469651593938 0.5726668321125709 1.0 16.782082181203066 -7.089524659370497 3.8123613972765122 0.6129796985330792 0.99925284215396 0.43694541072387494 0.1779411452050751 0.19423861407281698 5.198323906570163 0.0681227954838098 0.05269975607603779 8.137206561649585e-08 7.089524659370497 0.38627314362088083 ASS(ph)PPPQPQPPPPPAR ddPTM_A459_Selumetinib_30min_R1 1 ASSPPPQPQPPPPPAR 16 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 AS(0.007)S(0.993)PPPQPQPPPPPAR 188.13 8.971600000000002e-07 10375000.0 664.58 767.4 640.83 868.31 1154.5 770.35 790.7 600.76 353.58 730.67 True False 680.0634209524281 677.5524512454192 553.8088058272219 716.6759586973907 1050.0756788435303 762.6009784218362 731.0568624037783 584.8258932564999 599.9994355385537 824.4586118285043 0.8248605948140526 0.8218149965620796 0.6717242052926966 0.8692685702050335 1.2736548127196428 0.9249718148137493 0.8867114151217641 0.7093453629642594 0.7277496128130196 1.0 9.687303261353186 -5.98904018134502 24.227378394246877 0.9196023112896842 0.7765005289964626 0.15955210576873624 0.15143091557403932 320.7989013288874 709136.0757142726 0.047227172365158596 0.06996608145614545 1.025557036334071e-06 5.98904018134502 -0.14310178229322157 ASS(ph)PPPQPQPPPPPAR ddPTM_A459_Selumetinib_30min_R2 3 ASSPPPQPQPPPPPAR 16 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 AS(0.002)S(0.998)PPPQPQPPPPPAR;AS(0.007)S(0.993)PPPQPQPPPPPAR;AS(0.005)S(0.995)PPPQPQPPPPPAR 168.5 1.2948e-05 28499600.0 61472.0 61735.0 72745.0 73188.0 76620.0 50378.0 51807.6 50030.0 45906.5 58169.0 True False 58055.63233191329 66469.87599068813 68064.66589876752 63219.66814365787 66994.3106085092 57317.11221404857 54216.756054811885 50175.579017087635 55089.082734780146 56489.50982878754 1.0277241298052058 1.1766764518253001 1.2049080635513176 1.1191399666109438 1.1859602041433952 1.0146505499475813 0.9597667995196971 0.8882282598868955 0.9752090769020318 1.0 15.78569536171247 -6.934682385269011 3.568141818301179 0.9493253908783731 1.1466888740355972 0.7350619368701741 0.05328979530731558 0.11569966034896646 2.983722683114039 0.02006746762022489 0.017148730532515366 1.1622983324749317e-07 6.934682385269011 0.19736348315722407 ASS(ph)PQGFDVDR ddPTM_A459_Selumetinib_30min_R1 1 ASSPQGFDVDR 11 0 P27216;P27216-2 P27216 ANXA13 Annexin A13 1 AS(0.019)S(0.981)PQGFDVDR 140.45 0.0010849 4175300.0 2840.2 3450.4 3267.7 2918.2 3037.8 2563.1 3249.2 2876.7 1556.6 2243.8 True False 2906.3711339328393 3046.4255639525572 2823.96428819127 2408.5911513983774 2763.0315263671505 2537.317541108598 3004.110228054074 2800.400571161486 2641.4365104341664 2531.8135864628334 1.1479404129406288 1.203258241539292 1.1153918690106237 0.9513303681900971 1.0913250253259557 1.0021739178094284 1.1865447930750228 1.1060848184616514 1.0432981814133029 1.0 11.305955469923553 -5.522217026986021 24.9993446722291 1.0613508486155243 1.171530777584144 0.3713026314355775 0.0631129788567343 25.420492616318853 960363.1751652644 0.017387939761145273 0.030571449145556855 3.0045744721320115e-06 5.522217026986021 0.11017992896861961 ASS(ph)PSEHGPR ddPTM_A459_Selumetinib_30min_R2 1 ASSPSEHGPR 10 0 C9J052;Q9NSU2-2;Q9NSU2;Q9NSU2-1 C9J052 TREX1 Three-prime repair exonuclease 1 1 AS(0.49)S(0.508)PS(0.002)EHGPR 85.963 0.043044 0.0 0.0 0.0 795.39 870.22 801.49 909.13 1084.4 4999.5 2364.5 2283.9 True False 0.0 0.0 744.2154733551525 751.6945347867686 700.7996607884884 1034.3544052395487 1134.8267486978361 5014.047717288219 2837.4660696499973 2217.9578727151543 0.0 0.0 0.335540851569064 0.33891290003022817 0.31596617294204576 0.4663543965212128 0.5116538788487524 2.260659581937947 1.279314681561765 1.0 11.115016248267157 -7.621139633676367 6.447810126955953 1.5697591463013634 0.2634648862646645 0.7483887208027651 0.3296091241759409 0.09719907796698754 5.423043888163771 0.1537663700299018 0.0877136546808552 2.3925463849909702e-08 7.621139633676367 -1.306294260036699 ASS(ph)RVSGSFPEDSSK ddPTM_A459_Selumetinib_30min_R1 1 ASSRVSGSFPEDSSK 15 1 O15400-2;O15400 O15400-2 STX7 Syntaxin-7 1 AS(0.036)S(0.595)RVS(0.369)GSFPEDSSK 149.6 0.0013386 6188200.0 1091.6 886.4 1644.8 1296.9 1342.3 1330.6 1249.4 1453.8 543.01 917.55 True False 1117.0321561161488 782.6198759238194 1421.44519423968 1070.4207608280976 1220.889202002313 1317.2153720881363 1155.1567521022887 1415.2405013920695 921.4483101187576 1035.3264801938556 1.078917788239121 0.7559160234917212 1.3729439181093168 1.0338968251132445 1.179231117293274 1.272270532326672 1.115741531005752 1.3669509362177992 0.8900074785551942 1.0 10.015870064062415 -5.255096241446171 24.999586596965415 1.1664720701442544 0.9174169230929262 0.2457830210032752 0.16451110476468414 614.9004595249977 2423428.8443743093 0.038617201931171165 0.09702945584465288 5.557810802458389e-06 5.255096241446171 -0.24905514705132814 ASS(ph)SGPRSPLDQR ddPTM_A459_Selumetinib_30min_R1 1 ASSSGPRSPLDQR 13 1 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 AS(0.162)S(0.652)S(0.162)GPRS(0.024)PLDQR 83.292 0.017225999999999998 80472000.0 5560.1 6247.2 7739.8 8253.5 7431.1 6183.3 7244.7 6384.1 3287.5 4987.3 True False 5689.639511928729 5515.774919755516 6688.777671678183 6812.181162383154 6758.958317067261 6121.101615987207 6698.226446258568 6214.772929520643 5578.647390500019 5627.468535415852 1.0110477697248081 0.9801520674958191 1.188594414981283 1.2105231898697333 1.2010655012161335 1.0877184967743008 1.190273460278635 1.1043638699014762 0.9913244926011435 1.0 12.458270369895242 -10.33608313803665 9.394719047682328 0.9999983212822705 1.1134670820308052 0.12109802527147673 0.08518449736383478 0.0 0.0 0.08876114957415698 0.02152774089091161 4.612292718804103e-11 10.33608313803665 0.11346876074853474 ASS(ph)SKESPSPSVR ddPTM_A459_Selumetinib_30min_R1 1 ASSSKESPSPSVR 13 1 H0Y517;H7C1U3;Q5T0F9-3;Q5T0F9-2;Q5T0F9 H0Y517 CC2D1B Coiled-coil and C2 domain-containing protein 1B 1 AS(0.005)S(0.919)S(0.037)KES(0.037)PS(0.002)PSVR 159.58 0.0017291 2400700.0 1685.5 1864.2 2084.6 1947.8 1941.6 1369.1 1999.0 1520.8 1185.2 1467.9 True False 1724.7688705879161 1645.9385973569326 1801.522769888156 1607.6532947343421 1765.982622817322 1355.3280970433402 1848.2138205958668 1480.4634437453988 2011.1978364169192 1656.31926355682 1.0413263363755765 0.9937326900505911 1.0876663753940303 0.9706180022817754 1.06620907072288 0.8182770839317994 1.1158560195858422 0.8938273413340709 1.2142573480054952 1.0 10.693765070757703 -8.261289678883124 24.999999991026367 1.1071286588870348 1.0004966021426775 0.16516756876467253 0.09765523252764649 23.195344136014338 3875621.7174916384 0.07040691281161557 0.02265005873195361 5.479113804878827e-09 8.261289678883124 -0.10663205674435727 ASS(ph)VTTFTGEPNTCPR ddPTM_A459_Selumetinib_30min_R1 1 ASSVTTFTGEPNTCPR 16 0 H0YFA4;P52943;P52943-2 H0YFA4 CRIP2 Cysteine-rich protein 2 1 AS(0.002)S(0.979)VT(0.019)TFTGEPNTCPR 172.09 6.8644000000000016e-06 17066000.0 2261.5 2246.7 2027.3 2392.2 2223.2 2564.9 2251.4 2082.5 1071.9 1991.4 True False 2314.1885498870192 1983.6553195375075 1752.0037951617855 1974.4471771555063 2022.1119525378392 2539.0994347428673 2081.5750853874615 2027.2653350866594 1818.9360115215113 2247.015587878637 1.0298943017443858 0.8827955312095709 0.7797025550747594 0.8786975879502211 0.8999100689136186 1.1299874591168195 0.9263732288357802 0.9022035031811064 0.809489716641767 1.0 11.133794417402962 -4.752875789172488 24.26104727860668 0.9107610419572404 1.0298946327696201 0.12697882837953045 0.09257476924104235 524.8696155278523 1486811.8842460397 0.024573122336510572 0.27288787981728047 1.766542990336118e-05 4.752875789172488 0.11913359081237973 ASS(ph)VTTFTGEPNTCPR ddPTM_A459_Selumetinib_30min_R2 1 ASSVTTFTGEPNTCPR 16 0 H0YFA4;P52943;P52943-2 H0YFA4 CRIP2 Cysteine-rich protein 2 1 ASS(0.996)VT(0.004)TFTGEPNTCPR 168.45 1.3017e-05 12247000.0 30801.0 20983.0 29898.0 27436.0 22663.0 20264.0 17248.0 16655.0 17482.0 21188.0 True False 29089.203726172273 22592.32862902094 27974.395230481106 23699.16947026012 19815.871330209397 23055.18206172298 18050.06617626362 16703.46329261633 20978.888487892258 20576.247386964715 1.4137273516939057 1.0979809974161487 1.3595479634543663 1.1517731598266947 0.9630459314346588 1.1204755477584654 0.8772282835060848 0.8117837513558551 1.0195682474726961 1.0 14.328692272866519 -6.243589089331516 1.061542619927828 0.9274784393155644 1.2928869854214795 0.6318824073719549 0.11078336733635974 0.33283676822192443 0.7834496343097177 0.047902967129881534 0.07444498176097673 5.707039923622117e-07 6.243589089331516 0.3654085461059151 ASSASVPAVGAS(ph)AEGTR ddPTM_A459_Selumetinib_30min_R2 1 ASSASVPAVGASAEGTR 17 0 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 AS(0.008)S(0.171)AS(0.089)VPAVGAS(0.669)AEGT(0.063)R 70.41199999999998 0.032049 69367000.0 62231.0 49821.0 67903.0 69557.0 78804.0 63950.0 57122.0 61085.0 67107.0 65489.0 True False 58772.45015043107 53642.11050023603 63534.19490719648 60083.21660748233 68903.93700330143 72758.53201969923 59778.28618509568 61262.7472368339 80530.27512624323 63598.16240914347 0.9241218287461304 0.8434537802388443 0.9989941926067695 0.9447319597215942 1.0834265392767881 1.1440351303175196 0.9399373176936539 0.9632785746656446 1.266235879712547 1.0 15.956697460758523 -5.776223293659156 1.4166063881138706 1.0599799790849336 0.8879733835406664 0.33616567794945784 0.09490903647772726 0.5212800221439339 2.103616485697084 0.03198583385826029 0.0743771549836305 1.6740819210566722e-06 5.776223293659156 -0.17200659554426723 ASSDGEGT(ph)MSRPASVDGSPVSPSTNR ddPTM_A459_Selumetinib_30min_R1 1 ASSDGEGTMSRPASVDGSPVSPSTNR 26 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 AS(0.044)S(0.191)DGEGT(0.607)MS(0.156)RPAS(0.002)VDGSPVSPSTNR 79.025 0.00021665 15008000.0 880.07 820.75 1058.3 1039.2 1165.2 814.05 967.07 948.91 367.09 641.26 True False 900.573918681879 724.6562084436771 914.5886728257866 857.7232281999843 1059.8078657327683 805.8613960982618 894.1231313074767 923.7418243059213 622.9249188071943 723.5719674013532 1.2446224553394643 1.0014984563957305 1.263991301529347 1.1854014069677463 1.464688950760458 1.1137266677044497 1.235707257314906 1.2766412546680894 0.8609025043415873 1.0 9.498992705978141 -8.259798434109673 24.99928555858173 0.9304512330475526 1.2207949135211866 0.5025874449461998 0.1165077234817985 115.23330421406094 1755620.348469823 0.08836534448065536 0.029353035162870522 5.4979598740208025e-09 8.259798434109673 0.290343680473634 ASSDGEGTMSRPASVDGSPVS(ph)PSTNR ddPTM_A459_Selumetinib_30min_R2 3 ASSDGEGTMSRPASVDGSPVSPSTNR 26 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 ASS(0.001)DGEGT(0.003)MS(0.003)RPAS(0.001)VDGS(0.023)PVS(0.647)PS(0.221)T(0.102)NR;ASSDGEGTMSRPAS(0.016)VDGS(0.104)PVS(0.621)PS(0.185)T(0.074)NR;ASSDGEGTMSRPAS(0.001)VDGS(0.056)PVS(0.752)PS(0.131)T(0.059)NR 62.291 0.0020136 31704200.0 51506.3 48828.2 60436.3 58299.6 70172.0 38252.8 34240.2 40926.2 39308.8 43049.9 True False 48643.78604205537 52573.16593259117 56547.894256068095 50359.093907580485 61356.366014360596 43521.77597565518 35832.43714566913 41045.28846630284 47171.658379639615 41806.93752992692 1.163533827543201 1.2575225318754186 1.3525959469188351 1.2045630912699985 1.4676120672660962 1.0410180354516692 0.8570930870030595 0.9817817542105574 1.1283213066221947 1.0 15.351454745528816 -6.909939706886187 7.403084023523572 0.9846034980097846 1.2853838124504664 0.6816984411881617 0.0985901884392864 0.1318854462331876 9.29517258226603 0.03461719521005372 0.030521562723165873 1.2304395809131934e-07 6.909939706886187 0.30078031444068176 ASSDGEGTMSRPASVDGSPVSPS(ph)TNR ddPTM_A459_Selumetinib_30min_R2 1 ASSDGEGTMSRPASVDGSPVSPSTNR 26 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 ASSDGEGTMSRPAS(0.002)VDGS(0.028)PVS(0.283)PS(0.477)T(0.209)NR 61.177 0.0026559 16802000.0 18371.0 16672.0 20111.0 19843.0 24518.0 12391.0 14609.0 12511.0 12878.0 11145.0 True False 17350.013364939794 17950.688791070716 18817.080155201198 17140.349168915724 21437.829646298975 14097.747775701217 15288.347447184327 12547.404938692445 15453.959841384092 10823.214891812428 1.6030369477432047 1.6585357465876518 1.738585100942234 1.583665236276709 1.9807266011613904 1.3025471559624964 1.4125514091704576 1.1593047965983136 1.4278529989342392 1.0 13.401841475716248 -6.8514252973784675 9.017937993525004 1.2774896775023217 1.7036982657366384 0.6831488312304885 0.15383737302743208 0.1715106313835441 15.528332631220538 0.0512515340732358 0.04522312074003923 1.4079093808211108e-07 6.8514252973784675 0.42620858823431673 ASSDLSIAS(ph)SEEDKLSQNACILESVSEK ddPTM_A459_Selumetinib_30min_R1 1 ASSDLSIASSEEDKLSQNACILESVSEK 28 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 ASSDLS(0.006)IAS(0.797)S(0.192)EEDKLS(0.005)QNACILESVSEK 97.388 5.9765e-07 10905000.0 1085.6 991.93 1494.5 1251.2 771.29 940.36 919.72 1060.8 483.19 1163.7 True False 1110.8923677901164 875.7943744642539 1291.5551087008764 1032.7014079328521 701.5269556823096 930.9008321785655 850.3447799291798 1032.6641380359804 819.9381391986929 1313.0722303978957 0.8460253305741502 0.6669811105508376 0.9836131469397543 0.7864772280043697 0.5342637971025618 0.7089486858590237 0.6475993934252214 0.7864488442673528 0.6244425251078761 1.0 10.358730563856072 -6.013399044242737 24.899656453603104 0.698583982869319 0.8272441855300523 0.12089810500680687 0.13574425239914353 1071.8641596390637 1991866.7192300637 0.03730416200027815 0.05046754205702954 9.69618639898905e-07 6.013399044242737 0.1286602026607333 ASSDLSIAS(ph)SEEDKLSQNACILESVSEK ddPTM_A459_Selumetinib_30min_R2 2 ASSDLSIASSEEDKLSQNACILESVSEK 28 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 AS(0.001)S(0.003)DLS(0.01)IAS(0.491)S(0.491)EEDKLS(0.004)QNACILESVSEK;AS(0.002)S(0.002)DLS(0.017)IAS(0.414)S(0.414)EEDKLS(0.133)QNACILES(0.018)VS(0.002)EK 63.901 0.00064858 4261900.0 14509.5 14999.4 16800.2 19552.5 15783.8 13637.2 14682.6 14942.1 12485.900000000001 14845.8 True False 13703.120076130526 16149.805749327385 15719.29342267471 16889.41577005617 13800.897935037683 15515.600513823958 15365.369993019958 14985.579037202178 14983.428885194717 14417.163179979269 0.9504727043084097 1.1201791606100562 1.0903180623289104 1.1714798229869559 0.9572547499637531 1.07618956102058 1.0657693057367512 1.0394263316664303 1.0392771933109426 1.0 13.815499697470768 -6.266076758094044 24.99920585383805 1.035756836208571 1.0862747463727775 0.15173863830828915 0.060721086048428984 814.316375784105 4389809.1181362225 0.01838164758229894 0.021576421431573244 5.419051045218305e-07 6.266076758094044 0.05051791016420659 ASSDLSIASSEEDKLS(ph)QNACILESVSEK ddPTM_A459_Selumetinib_30min_R1 1 ASSDLSIASSEEDKLSQNACILESVSEK 28 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 ASSDLSIAS(0.008)S(0.007)EEDKLS(0.984)QNACILESVSEK 77.907 4.5784e-05 4327800.0 363.82 398.47 407.4 609.24 366.1 381.93 435.03 538.33 202.78 157.64 True False 372.29629812951396 351.8169471563229 352.07731768801403 502.84767085119194 332.9863196402049 378.088130964694 402.21533685533757 524.05173965772 344.1028495347814 177.87462954363184 2.093026414642181 1.97789278920198 1.9793565759846097 2.8269780358297005 1.8720281835275718 2.125587735219714 2.2612293719868353 2.946185979429812 1.9345246166788195 1.0 7.474716941853978 -7.217347263675503 23.01592792232738 2.1976678177738105 2.1491302591430426 0.0 0.5163412160470886 3225.7332589616362 1683817.0943788905 0.19083783114065592 0.14781954985810464 6.062513746056454e-08 7.217347263675503 -0.04853755863076792 ASSEDVASS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 ASSEDVASSPER 12 0 M0R2H0;A0A087WWI0;Q9H2I8 M0R2H0 C10orf11 Leucine-rich repeat-containing protein C10orf11 1 ASSEDVAS(0.002)S(0.998)PER;ASSEDVAS(0.003)S(0.997)PER 184.96 0.00010448 10700800.0 7581.8 7442.0 8800.1 8396.9 9036.3 6708.9 7561.299999999999 7508.1 3829.3999999999996 6481.0 True False 7758.441188385322 6570.687180308066 7605.094755489186 6930.539044334533 8218.968260488344 6641.414557193824 6990.945053362445 7308.960798254091 6498.212111689968 7312.899480285958 1.0609254522505678 0.8985064266261638 1.0399561454373776 0.9477142497333393 1.1239000731030089 0.9081780181852197 0.9559744492876684 0.999461406239415 0.8885958475441628 1.0 12.83622781620935 ASSEDVASS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 ASSEDVASSPER 12 0 M0R2H0;A0A087WWI0;Q9H2I8 M0R2H0 C10orf11 Leucine-rich repeat-containing protein C10orf11 1 ASSEDVAS(0.418)S(0.582)PER;ASSEDVAS(0.004)S(0.996)PER 144.51 0.00073684 24456200.0 107624.0 92422.0 121047.0 108008.0 105899.0 84999.0 90402.0 93008.0 70855.0 82672.0 True False 101642.68893300748 99510.47021643115 113258.96780600873 93297.12407580751 92595.02087092801 96706.84070590178 94605.87212816454 93278.6378816966 85027.97985411319 80285.04455234771 1.2660227007376708 1.239464594823112 1.4107106552349393 1.1620735168799168 1.1533283862171106 1.2045436512505971 1.1783747851877857 1.1618432598723512 1.0590761994118716 1.0 16.29284364799399 -7.596262416569751 0.2831090086177126 0.9726991479811102 1.3328502229685346 0.6634919758214719 0.06167231934983511 1.1463315502323888 0.31321736934854116 0.12248191626193974 0.15298889431834778 2.5335972759903708e-08 7.596262416569751 0.3601510749874244 ASSES(ph)SYLSILPK ddPTM_A459_Selumetinib_30min_R2 1 ASSESSYLSILPK 13 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 AS(0.001)S(0.006)ES(0.882)S(0.111)YLSILPK 119.39 0.0027015 0.0 12788.0 11287.0 13124.0 11666.0 13312.0 9757.2 12253.0 12327.0 8383.8 14583.0 True False 12077.29415442002 12152.676606574807 12279.616128330796 10077.070675027513 11639.627549210054 11101.165732957135 12822.788778858883 12362.869529155289 10060.79426294424 14161.950898815663 0.8527987592041447 0.8581216453441532 0.8670850658970803 0.7115594981952832 0.821894358508435 0.7838726325400199 0.9054394320722599 0.8729637334210198 0.7104101924111038 1.0 13.78973239907887 -7.252022700188701 24.717510609848574 0.8616169852842558 0.8156662044977262 0.1038994875798247 0.07859741016478147 1694.9953629886043 4449144.041877175 0.030086040506690493 0.02295225052743232 5.597283442246761e-08 7.252022700188701 -0.04595078078652959 ASSESSYLSILPKT(ph)PEGISEEQR ddPTM_A459_Selumetinib_30min_R1 2 ASSESSYLSILPKTPEGISEEQR 23 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 ASSESSYLSILPKT(0.939)PEGIS(0.061)EEQR;ASSESSYLSILPKT(0.942)PEGIS(0.058)EEQR 141.21 3.2032e-06 13824400.0 1490.67 1244.75 2606.7 2760.8999999999996 1777.81 1727.19 1369.57 1303.9699999999998 913.14 1175.8600000000001 True False 1525.3997106611034 1099.0140913314249 2252.724457578171 2278.760643511678 1617.0073993978494 1709.8160367630448 1266.2622322528664 1269.3844797084998 1549.531886893136 1326.793084846326 1.1496892228962594 0.8283236503744038 1.6978717203964697 1.7174951162604322 1.2187336653063254 1.288683259124072 0.954378076517884 0.9567313051345339 1.1678775723138535 1.0 10.373727682693612 -7.178640326487037 4.650925711433041 1.0164879015917605 1.329977293441349 0.2562714500064448 0.24771493692291588 0.35260330656513994 13.6275071946531 0.10777520815452318 0.08194631163241664 6.627651645803383e-08 7.178640326487037 0.31348939184958846 ASSESSYLSILPKT(ph)PEGISEEQR ddPTM_A459_Selumetinib_30min_R2 2 ASSESSYLSILPKTPEGISEEQR 23 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 ASSESSYLSILPKT(0.891)PEGIS(0.109)EEQR;ASSESSYLSILPKT(0.947)PEGIS(0.053)EEQR 130.15 1.1067e-05 9969100.0 18347.1 25648.6 23054.0 21666.6 19018.8 11659.3 8209.400000000001 8559.8 5308.9 22099.0 True False 17327.441631260517 27615.76514675242 21570.730739297327 18715.57170303025 16629.48831377074 13265.262742412486 8591.153366617498 8584.70760084883 6370.828343059789 21460.944449902454 0.8073941793059939 1.2867916978778602 1.0051156317771175 0.8720758653804408 0.774872156842395 0.6181117878282743 0.40031571707723923 0.40001536842372515 0.29685684886476404 1.0 14.389425946939722 -6.461458543404808 1.2887510495096877 0.47704820023918837 1.0534476778428574 0.5025944009072838 0.21180397588304917 0.3134277341106505 1.0753203777793354 0.08667403046338651 0.10286084060765731 3.455743156077264e-07 6.461458543404808 0.576399477603669 ASSHS(ph)SQTQGGGS(ph)VTK ddPTM_A459_Selumetinib_30min_R1 1 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 AS(0.006)S(0.482)HS(0.508)S(0.085)QT(0.411)QGGGS(0.507)VT(0.001)K 148.41 0.0052618000000000005 3275400.0 923.6 1300.8 1091.3 1036.3 1626.9 1069.0 1271.8 1009.4 250.79 691.18 True False 945.1180829872435 1148.5017312744862 943.1074540818117 855.3296587602422 1479.747182252524 1058.24683057434 1175.8671020679453 982.6274330067101 425.57231302311794 779.8996856633311 1.2118457031860304 1.4726275088797436 1.2092676422605133 1.0967175323743787 1.8973557874868856 1.3569012143840848 1.5077158302324876 1.2599407988874265 0.5456757078458806 1.0 9.607144759514846 -8.115331132542032 5.210209158224186 0.7828356264488466 1.3950475695751563 0.5267714159733043 0.2313917916835354 0.17231780638558844 6.563717843885235 0.16233770915197768 0.058953894206077315 7.667766292592796e-09 8.115331132542032 0.6122119431263097 ASSHS(ph)SQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 6 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 ASS(0.001)HS(0.908)S(0.089)QT(0.002)QGGGSVTK;ASS(0.096)HS(0.819)S(0.081)QT(0.004)QGGGSVTK;ASS(0.003)HS(0.982)S(0.015)QTQGGGSVTK;ASS(0.001)HS(0.905)S(0.094)QTQGGGSVTK;AS(0.001)S(0.011)HS(0.791)S(0.093)QT(0.105)QGGGSVTK;AS(0.001)S(0.382)HS(0.608)S(0.008)QT(0.001)QGGGSVTK 230.45 1.5022e-51 42379100.0 9862.060000000001 10626.55 9376.319999999998 10420.16 12551.279999999999 11119.16 10606.64 9906.010000000002 5411.09 7399.780000000001 True False 10091.826809771735 9382.388585850933 8103.067244439075 8600.474666628505 11416.018940108463 11007.311345789503 9806.572605345147 9643.270435544679 9182.22451962304 8349.61384296103 1.2086579091653973 1.1236913182231252 0.9704720956970003 1.0300446018684994 1.36725112739585 1.318301846386464 1.1744941490452732 1.154936098472894 1.099718465107692 1.0 13.027493761323315 -3.9537639112040384 3.8902160736149507 1.1484342557203127 11.185849075993046 0.022718116266724264 0.12174086689095631 3693.22825005526 314.2851161051146 0.033686288152436426 325959.46367273177 0.00011123362451130263 3.9537639112040384 10.037414820272733 ASSHS(ph)SQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 2 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.322)S(0.322)HS(0.335)S(0.02)QTQGGGSVTK;AS(0.248)S(0.248)HS(0.476)S(0.029)QTQGGGSVTK 77.726 0.018074 69014000.0 52079.0 45553.9 78250.0 129310.0 148113.0 86814.0 76353.0 116183.0 114524.0 166848.0 True False 49184.65766875511 49047.737651125026 73215.4801921582 111697.75492780806 129505.72079297973 98771.84048097218 79903.56579059926 116521.07329486903 137432.00006791993 162030.66471683406 0.3035515391775413 0.3027065138370024 0.4518618763930278 0.6893618261889615 0.7992667376839122 0.6095873312226828 0.4931385422027324 0.719129761631862 0.8481851278466152 1.0 17.305907347104686 -5.735642400705954 0.21717642031970552 0.9940438666304905 4.637937446573596e-19 0.7239000431130218 0.11613586851201822 5.412296004278825 0.3459500527328227 0.29056593762040406 1.479908455239962 1.8380511769196547e-06 5.735642400705954 -0.9940438666304905 down ASSHSS(ph)QTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 3 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.001)S(0.006)HS(0.345)S(0.647)QT(0.001)QGGGSVTK;AS(0.001)S(0.001)HS(0.024)S(0.961)QT(0.013)QGGGSVTK;ASSHS(0.065)S(0.935)QTQGGGSVTK 322.68 1.2417999999999992e-117 295172200.0 29010.5 33311.0 27873.5 29208.1 47472.8 35381.5 39165.5 30935.8 11382.2 18702.7 True False 29686.388205393516 29410.932634136236 24088.431798175916 24107.453638941453 43178.89362200356 35025.59423383164 36211.214802675066 30115.282090359597 19314.7620770036 21103.373724725217 1.4067129072643125 1.3936602278752086 1.1414493299691382 1.1423506948889686 2.046065912741437 1.6597153938848561 1.71589695917905 1.4270363821058532 0.9152452270877411 1.0 14.365186035678773 -8.217008246025062 5.10947325052455 0.9543912996352484 1.4997792116421882 0.4124976251061865 0.25552576440607755 0.20199493968496024 12.68226104926847 0.2122237189484279 0.07265274063526499 6.067248094893783e-09 8.217008246025062 0.5453879120069398 ASSHSS(ph)QTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 2 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.017)S(0.337)HS(0.057)S(0.585)QT(0.003)QGGGSVTK;ASS(0.033)HS(0.082)S(0.717)QT(0.167)QGGGSVTK 236.75 2.9204999999999998e-21 307990000.0 14177.9 11248.8 22327.0 34515.0 41107.0 22273.0 20280.8 30286.0 33906.0 45818.0 True False 13389.949076630548 12111.546789407166 20890.505127799566 29813.997458304013 35942.77115875731 25340.903575836757 21223.897385642802 30374.127245882795 40688.147412794606 44495.1152905394 0.30093076485358683 0.2721994697692656 0.4695010899823723 0.6700510216374942 0.8077913929217192 0.569521022934056 0.476993873306256 0.6826395897066251 0.9144407683206018 1.0 15.441359344102159 -6.000942603187974 0.20435675058707325 1.0355375116032777 1.8122675572373296e-15 0.6955971716773248 0.12833793110409109 5.683214226000574 0.37477293362313485 0.3860328552866986 1.5852176112507554 9.978319296179136e-07 6.000942603187974 -1.035537511603276 ASSHSSQT(ph)QGGGSVTK ddPTM_A459_Selumetinib_30min_R1 2 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 ASSHS(0.001)S(0.001)QT(0.572)QGGGS(0.426)VTK;ASSHSSQT(0.557)QGGGS(0.281)VT(0.161)K 236.75 3.2321999999999996e-64 2513700.0 1420.87 2080.3500000000004 1432.79 1549.33 2874.9 1792.58 2287.13 1596.51 960.74 845.96 True False 1453.9735064682598 1836.7816548715248 1238.2249877521108 1278.7686000260605 2614.865802604821 1774.5482727324156 2114.609942721072 1554.16536860466 1630.305610326689 954.5472063482041 1.5232075446857185 1.9242439165460143 1.2971857017833284 1.3396598843112484 2.7393781944095474 1.8590471596698463 2.215301588709165 1.6281702552463648 1.7079360763766969 1.0 9.898672736466695 -8.881325691329744 1.5924353113846497 1.0012765169358024 1.8329111406281378 0.26588703478699394 0.40501773260540314 2.183523773429128 7.874087425938545 0.4043242350231604 0.11580151965720187 1.314238872749826e-09 8.881325691329744 0.8316346236923353 ASSHSSQTQGGGS(ph)VTK ddPTM_A459_Selumetinib_30min_R1 1 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 ASSHSSQTQGGGS(1)VTK 241.79 1.3799e-21 585880.0 74.393 273.37 185.16 59.076 165.44 155.41 197.43 316.66 227.76 0.0 True False 76.12621215642055 241.36371331373496 160.01628901107688 48.759485593862834 150.47598121080432 153.84671650098997 182.53769614819504 308.2611481433574 386.49208506776705 0.0 0.0 ASSHSSQTQGGGS(ph)VTK ddPTM_A459_Selumetinib_30min_R2 3 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 AS(0.001)S(0.001)HS(0.001)S(0.004)QT(0.13)QGGGS(0.84)VT(0.024)K;ASSHSS(0.008)QT(0.084)QGGGS(0.908)VTK;ASSHSSQT(0.001)QGGGS(0.906)VT(0.093)K 122.14 0.0014694 20365900.0 6104.83 5261.4 11142.380000000001 14680.3 18340.989999999998 12488.8 11074.619999999999 26019.0 20131.1 33937.3 True False 5765.54798817078 5664.932461932549 10425.491401706066 12680.817815069968 16036.830865669028 14209.018837961206 11589.611773943216 26094.710982322675 24157.88250993067 32957.441969305146 0.1749391834942928 0.1718862910297642 0.3163319353308982 0.38476341176236384 0.48659209900467704 0.4311323327579474 0.35165386272202737 0.7917699136548867 0.7330023529262396 1.0 15.008316649940307 -7.53238784627303 0.24839928010727888 1.1169132185108899 0.01376901649894701 0.8759984979249306 0.09143343740305523 0.7792354569933118 0.17576745383803136 0.24143224554400494 0.3288273763240574 2.9350273578333634e-08 7.53238784627303 -1.1031442020119429 down ASSHSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 1 ASSHSSQTQGGGSVTK 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 123.42 0.0019224 1138300.0 1039.3 1090.8 869.89 915.06 1331.4 1159.4 1227.4 882.39 289.62 633.22 False True 1063.5136678742338 963.0886289008373 751.7637159637376 755.2619488035772 1210.975105077762 1147.7374886509742 1134.8162298145905 858.986150793334 491.46398699212654 714.4999550851215 1.4884726868142808 1.3479197892827024 1.0521536224227988 1.0570496798892024 1.6948567966438755 1.606350679916053 1.5882663417094196 1.2022200207010498 0.687843272059515 1.0 9.48079011040516 -8.061259224747072 4.93504377303639 0.8578556813905206 1.395530308509684 0.5142223659030318 0.2157111747076708 0.1974197127199271 9.620105758131434 0.16774352884013552 0.062145585520911754 8.68441912832497e-09 8.061259224747072 0.5376746271191634 ASSLSESS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 ASSLSESSPPK 11 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VRN8;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 ASSLS(0.003)ES(0.108)S(0.889)PPK;ASSLS(0.003)ES(0.114)S(0.883)PPK 95.618 0.021044 141978000.0 10913.2 13441.5 14930.2 14091.199999999999 10933.3 11872.900000000001 11229.599999999999 10583.900000000001 7746.9 10598.7 True False 11167.45632660934 11867.762931216186 12902.760845718189 11630.436444583927 9944.384945430897 11753.469405730673 10382.542230997173 10303.180590647635 13145.923488810513 11959.146385080501 0.9338004542315139 0.9923586976091939 1.0789031616683682 0.9725139295136773 0.8315296615013344 0.9828017006626478 0.868167500980655 0.8615314386904113 1.0992359375423786 1.0 13.545826796680693 -4.390839639242267 11.972648624541227 0.9583172776684525 0.00023759194531562796 0.0063663091070083055 0.08465571895609603 1357342.4741159705 1716972.7001055682 0.021634927105770117 34446314.14106334 4.065934337547462e-05 4.390839639242267 -0.958079685723137 ASSLSESS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 ASSLSESSPPK 11 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VRN8;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 ASSLS(0.002)ES(0.086)S(0.912)PPK 131.12 0.0022643 15502000.0 58996.0 48213.0 59031.0 51345.0 54507.0 40697.0 49955.0 38232.0 38567.0 53216.0 True False 55717.238499700004 51910.78207077093 55233.00972809321 44351.72242493463 47659.34336123742 46302.64233941668 52278.006483954625 38343.2487903517 46281.47765201586 51679.51580822701 1.078130041048686 1.004475008307007 1.068760201489746 0.8582070039029691 0.9222095566470146 0.8959573559326116 1.011580810430742 0.7419428798953207 0.895547818670704 1.0 15.657304932856402 -5.757496956027533 24.99950886205698 0.8978344487601918 1.0458571043534728 0.4584033978453679 0.07289035594742893 88.39575441904204 560520.7991553935 0.019679495824808674 0.03252916813304396 1.747845513034319e-06 5.757496956027533 0.14802265559328098 ASSNKDFT(ph)PNR ddPTM_A459_Selumetinib_30min_R1 2 ASSNKDFTPNR 11 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;Q7Z6E9-4 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 ASSNKDFT(1)PNR;ASSNKDFT(1)PNR 138.31 0.013075 31358700.0 5174.1 5811.8 7056.0 7407.099999999999 6030.6 5941.5 5652.4 5108.3 3359.3900000000003 4222.72 True False 5294.646462953986 5131.351754167483 6097.833955833651 6113.5890334874 5485.133294788909 5881.733904450366 5226.034917226654 4972.811289903089 5700.639469862163 4764.747244775977 1.1112124507252688 1.076941019231072 1.2797812019345323 1.2830877944659667 1.1511908214654525 1.2344272638803753 1.09681262168868 1.0436673834808827 1.196420119894563 1.0 12.218183970281075 -7.339895083986627 6.984587198893686 1.0868875307229622 1.1908332430482937 0.304492894589518 0.07789809943640605 0.3721243955397541 28.438290369612417 0.034195288293796214 0.022953508332515516 4.5719862542657e-08 7.339895083986627 0.10394571232533156 ASSNPNATSSS(ph)SQDPESLQDRGEGK ddPTM_A459_Selumetinib_30min_R2 1 ASSNPNATSSSSQDPESLQDRGEGK 25 1 C9JZJ9;A0A087WUD9;B5MCB9;H9KV48;E9PGN7;P05155;P05155-3 C9JZJ9 SERPING1 Plasma protease C1 inhibitor 1 AS(0.018)S(0.018)NPNAT(0.266)S(0.266)S(0.061)S(0.311)S(0.061)QDPESLQDRGEGK 52.92 0.01131 27238000.0 28158.0 25770.0 29304.0 30742.0 30534.0 20396.0 25494.0 26761.0 25674.0 28579.0 True False 26593.091085404973 27746.476136389916 27418.6125437828 26554.886567092024 26698.045942576584 23205.363863546274 26679.52151540265 26838.87007947796 30809.517391496734 27753.850012840507 0.9581766519996865 0.9997343115838999 0.9879210463087966 0.9568001035822499 0.9619582843542266 0.8361133267208029 0.9612908300311195 0.9670323240581317 1.1100988647428196 1.0 14.760400295486495 -8.124786619854094 6.244788149870548 1.0539427866822102 0.9520036102471103 0.4158975907363345 0.04831762619574023 0.23206913342377183 10.632963725265151 0.03476858783290116 0.012864345079079369 7.502627423395849e-09 8.124786619854094 -0.10193917643509987 ASSPAES(ph)SPEDSGYMR ddPTM_A459_Selumetinib_30min_R2 3 ASSPAESSPEDSGYMR 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 AS(0.014)S(0.202)PAES(0.783)SPEDSGYMR;AS(0.001)S(0.001)PAES(0.895)S(0.102)PEDSGYMR;ASS(0.002)PAES(0.499)S(0.499)PEDSGYMR 280.5 1.3896e-62 27734200.0 100567.0 72331.0 96905.0 91502.0 89137.0 67157.0 72127.0 80732.0 60618.0 78123.0 True False 94977.88874159812 77878.55511917803 90670.2378021864 79039.26975024588 77938.8131651094 76407.26715945176 75481.04841693907 80966.91675409795 72743.29380843467 75867.38600206916 1.2518935177100703 1.0265090076657446 1.1951148257528408 1.0418082645959386 1.0273032626032976 1.0071161165005458 0.99490772510444 1.0672163761104108 0.9588216708356171 1.0 16.21119221031487 -1.5228787452935086 0.36287327081494614 0.9960652648644114 3.7269595568052454 0.5837411393206446 0.057140531264259484 46.89688509580892 0.6527762725953672 0.04442349435134879 88.69310136915611 0.029999999999090175 1.5228787452935086 2.730894291940834 ASSPAESS(ph)PEDSGYMR ddPTM_A459_Selumetinib_30min_R1 1 ASSPAESSPEDSGYMR 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 ASS(0.001)PAES(0.39)S(0.609)PEDSGYMR 144.88 0.00038808 6097400.0 1757.6 1830.7 1851.3 2259.9 2122.3 1450.8 1691.0 1783.1 926.55 1434.2 True False 1798.5486603057386 1616.3607929306588 1599.9036284629867 1865.2508885769282 1930.338339722498 1436.2062692210047 1563.44650856809 1735.8063956749213 1572.2876774654883 1618.2935402910234 1.111385923212855 0.9988056880212122 0.9886362323211587 1.1526035556203813 1.1928233609431318 0.8874819267725228 0.9661081068685041 1.0726152904019906 0.9715713733756475 1.0 10.660257604859984 -6.766850495622094 24.999985417417324 0.9832533656276281 1.081822761490945 0.3639073249224518 0.07186740864589226 185.04545528729847 854924.513805914 0.027179872750250807 0.024660723107276534 1.7106040833011076e-07 6.766850495622094 0.09856939586331692 ASSPHGLGS(ph)PLVASPR ddPTM_A459_Selumetinib_30min_R2 1 ASSPHGLGSPLVASPR 16 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 ASS(0.004)PHGLGS(0.996)PLVASPR 137.17 0.00040796 6749100.0 33550.0 32835.0 27756.0 33161.0 29504.0 27465.0 24894.0 23590.0 19142.0 35068.0 True False 31685.42531129118 35353.33891883439 25970.209178447843 28644.41459408426 25797.44375089344 31248.05444755339 26051.620326525197 23658.642994465255 22970.93487216758 34055.49572239372 0.93040564053384 1.038109655105894 0.7625849698429357 0.8411098997818633 0.7575119141175773 0.9175627541080174 0.7649755134644699 0.694708518922194 0.6745147702273112 1.0 15.055600012196901 -5.2656600658351405 24.97486709340102 0.7933847688707028 0.9842576527774491 0.36201656114332115 0.09648702215722693 322.57245839369756 1908753.6750274226 0.02476061873506218 0.054653078496072684 5.424252953922002e-06 5.2656600658351405 0.1908728839067464 ASSPHGLGSPLVAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ASSPHGLGSPLVASPR 16 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 ASSPHGLGSPLVAS(1)PR 120.59 0.0014312 0.0 1170.5 1507.0 1536.7 1692.6 1365.7 1213.6 1417.0 1536.7 810.63 1166.2 True False 1197.7703726034742 1330.5597394147069 1328.0245804888846 1397.0191840370414 1242.1726761339191 1201.392285860636 1310.1145491667544 1495.9417240949197 1375.57990392731 1315.8931297499594 0.9102337762270023 1.0111457452988863 1.00921917628769 1.0616509444824727 0.9439768686762212 0.9129862134692653 0.995608624703206 1.1368261527280505 1.0453583751050453 1.0 10.36182661002666 -7.578300282353594 11.325890448880907 1.0680524546255858 0.9784298792605503 0.3347415329132921 0.05379669381862617 0.7086469111063335 141.91836252807792 0.025975385870112375 0.014988189637392537 2.6405823595555722e-08 7.578300282353594 -0.0896225753650356 ASSPHGLGSPLVAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ASSPHGLGSPLVASPR 16 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 ASSPHGLGSPLVAS(1)PR;ASSPHGLGS(0.001)PLVAS(0.999)PR 129.06 0.00059678 48983000.0 156997.0 179564.0 192692.0 232570.0 236030.0 134134.0 195590.0 174133.0 157327.0 130889.0 True False 148271.73524878646 193335.9814107379 180294.4065071862 200893.56479437253 206377.80126502755 152609.74095278085 204685.32255423252 174639.69820073008 188796.79608366467 127109.89447953648 1.166484606535936 1.5210144119965674 1.4184136274002803 1.5804714937177022 1.6236171236713006 1.2006126004403976 1.6103020413346734 1.373926860027765 1.485303696118316 1.0 16.955716811317522 -10.900104729460326 3.550681068804087 0.9972443752551977 1.449082280730679 0.43465724795574634 0.15112613987164247 105177398.4653358 165733960.1086876 3027549.718795014 0.03594611575794904 1.2586218604288227e-11 10.900104729460326 0.4518379054754812 ASSPS(ph)PLTIGTPESQR ddPTM_A459_Selumetinib_30min_R1 2 ASSPSPLTIGTPESQR 16 0 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 ASS(0.012)PS(0.979)PLT(0.009)IGTPESQR;ASS(0.012)PS(0.988)PLTIGTPESQR 316.54 5.373199999999999e-103 121642000.0 3287.4 4453.4 3136.8 3194.3999999999996 3256.3999999999996 2867.0 3491.1 3337.2 1716.1 3320.1000000000004 True False 3363.990023833118 3931.9938576705104 2710.83978920904 2636.5580063145007 2961.8591949641154 2838.160583027723 3227.7635162992633 3248.686615246675 2912.096361015082 3746.2671755126353 0.8979578514372224 1.0495764646397545 0.7236109071259959 0.7037826942905419 0.7906161136408585 0.7575969491923256 0.8615945860448619 0.8671796385697259 0.7773328021156403 1.0 11.871238077740637 -10.527749870043177 16.148756883993194 0.99999999935426 0.8247559196332096 0.22983148436911904 0.09583804051217093 0.0 0.0 0.10021361836523959 0.024305372567365927 2.966539462682042e-11 10.527749870043177 -0.17524407972105038 ASSPS(ph)PLTIGTPESQR ddPTM_A459_Selumetinib_30min_R2 4 ASSPSPLTIGTPESQR 16 0 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 ASS(0.003)PS(0.997)PLTIGTPESQR;ASS(0.001)PS(0.999)PLTIGTPESQR;ASS(0.082)PS(0.915)PLT(0.003)IGTPESQR;ASS(0.013)PS(0.987)PLTIGTPESQR 292.76 7.992e-75 155262000.0 133412.0 108196.0 125156.0 133294.0 154088.0 125673.0 131121.0 131421.0 117359.0 112108.0 True False 125997.49513055063 116494.28529502705 117103.59921954975 115139.12725502437 134730.08787580222 142983.3150040916 137218.38631133258 131803.41335208213 140834.07928443802 108871.15074843513 1.157308380267687 1.070019784802371 1.07561643662734 1.0575724281731205 1.2375187269501582 1.3133260190707297 1.2603741704576856 1.2106367246602896 1.2935849241628623 1.0 16.732262186194923 -6.268608804836827 23.984288767271924 1.2365329427781704 1.0876562351969683 0.3448445592344064 0.08517769047393857 303.78477324685986 1016267.0070935369 0.024705938555082522 0.028625145497868786 5.387548529202075e-07 6.268608804836827 -0.14887670758120208 ASSPS(ph)PLTIGTPESQRK ddPTM_A459_Selumetinib_30min_R2 2 ASSPSPLTIGTPESQRK 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 AS(0.062)S(0.32)PS(0.615)PLT(0.002)IGTPESQRK;AS(0.001)S(0.008)PS(0.989)PLT(0.002)IGTPESQRK 123.63 0.00068909 13642400.0 47044.0 45740.0 50006.0 55927.0 53213.0 36363.0 38034.0 35972.0 35906.0 46967.0 True False 44429.48281205314 49248.110922719236 46788.66840241614 48309.64612054373 46527.90720974416 41371.67317955156 39802.656362941234 36076.672564514825 43088.203297463646 45610.940675078884 0.9740970511561653 1.079743372835712 1.0258211672442166 1.059167940970342 1.020104091717764 0.9070559073594464 0.8726558973314223 0.7909653260939336 0.9446900822417456 1.0 15.477092304037528 -6.771356904271561 3.6265361600235955 0.8851962963333477 1.03776678711705 0.5565443271735628 0.0567419143996252 0.14832070781186274 4.166173375697036 0.019579173738566855 0.01814681163380739 1.6929459614694542e-07 6.771356904271561 0.15257049078370222 ASSQALGT(ph)IPK ddPTM_A459_Selumetinib_30min_R1 1 ASSQALGTIPK 11 0 F8W126;Q96EZ8-3;Q96EZ8;Q96EZ8-2;F8W0I9;F8VVA6;F8VP44 F8W126 MCRS1 Microspherule protein 1 1 ASS(0.325)QALGT(0.675)IPK 127.4 0.0069578 35420000.0 2988.9 3190.3 3106.3 3200.0 2732.6 2753.8 2931.7 2584.8 1741.6 2196.6 True False 3058.535554613007 2816.7781928697673 2684.4815216845336 2641.1800714395213 2485.4368124797147 2726.099272250346 2710.559508674788 2516.2427073863137 2955.367998568768 2478.5550066959013 1.2339994659591047 1.1364598264957382 1.083083294271184 1.0656128527727982 1.0027765394615904 1.0998744288045637 1.0936047420178767 1.015205513127043 1.1923753923494698 1.0 11.275283561629209 -4.804773972193585 1.645420810626158 1.0677829237049805 1.289225370937867 0.4785379036690589 0.05373754299401687 0.7975059112475646 2.1958053808230105 0.014319116073364488 0.2808761920130584 1.5675666951996813e-05 4.804773972193585 0.22144244723288642 ASSRVS(ph)GSFPEDSSK ddPTM_A459_Selumetinib_30min_R2 1 ASSRVSGSFPEDSSK 15 1 O15400-2;O15400 O15400-2 STX7 Syntaxin-7 1 AS(0.097)S(0.097)RVS(0.759)GS(0.047)FPEDSSK 64.83 0.037271 5323600.0 32772.0 19140.0 33218.0 35980.0 24016.0 19945.0 37123.0 24485.0 21053.0 31246.0 True False 30950.663436710405 20607.97645519997 31080.7900450238 31079.461931038033 20998.89537423593 22692.242707316647 38849.293057828974 24556.247296290032 25264.188269968858 30343.84679314232 1.0199980130306099 0.679148447976522 1.0242864148670838 1.0242426460596934 0.6920314196610583 0.7478367150352563 1.280302175352694 0.8092661244862244 0.8325967515654127 1.0 14.889116372108507 ASSS(ph)GPRSPLDQR ddPTM_A459_Selumetinib_30min_R1 1 ASSSGPRSPLDQR 13 1 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 AS(0.003)S(0.013)S(0.817)GPRS(0.167)PLDQR 118.76 0.015948 63507000.0 3344.1 4115.8 4074.0 4511.3 4273.6 3407.2 3911.3 3783.7 1923.7 3120.4 True False 3422.0110235141233 3633.9202226164916 3520.773176880143 3723.486142589095 3887.0536345653604 3372.9266614900785 3616.2674919943065 3683.3439848102703 3264.3783985109912 3520.933735269912 0.9719044096840392 1.0320899215497215 0.9999543989174915 1.057528037318673 1.1039837517042568 0.9579636866501585 1.0270762712088037 1.0461270395160982 0.9271342899217461 1.0 11.781742360287703 -10.14050790628985 7.971998351539489 1.000001092253223 1.0175296625375934 0.0017129677701764878 0.04930021382578081 0.0 0.0 0.0469015786775353 0.011375303699746774 7.235892292870589e-11 10.14050790628985 0.01752857028437038 ASSS(ph)KESPSPSVR ddPTM_A459_Selumetinib_30min_R1 2 ASSSKESPSPSVR 13 1 H0Y517;H7C1U3;Q5T0F9-3;Q5T0F9-2;Q5T0F9 H0Y517 CC2D1B Coiled-coil and C2 domain-containing protein 1B 1 AS(0.001)S(0.046)S(0.755)KES(0.1)PS(0.099)PSVR;AS(0.009)S(0.256)S(0.522)KES(0.191)PS(0.022)PSVR 162.67 0.0017244 7227900.0 2611.0 2668.2 2839.7 3213.0 2181.77 2393.02 2528.6 2823.5 1460.82 1938.77 True False 2671.8312198784056 2355.8059035874717 2454.0843373555567 2651.909865479745 1984.4292887227793 2368.948391488316 2337.865666212461 2748.6116079794406 2478.9048459285896 2187.630014719024 1.2213359671889361 1.0768758372014053 1.1218004511017625 1.212229603560432 0.9071137602661099 1.0828834746046305 1.068675073244839 1.2564334871463483 1.1331462949629425 1.0 11.0951530460717 -4.754350550552046 24.686703291252027 1.1008315545288754 1.2213362141672233 0.13762330456925043 0.09366379464413663 479.4995592824785 1669675.904596837 0.023731812392648488 0.23286352249672518 1.7605544016779424e-05 4.754350550552046 0.12050465963834789 ASSSGPRS(ph)PLDQR ddPTM_A459_Selumetinib_30min_R1 1 ASSSGPRSPLDQR 13 1 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 ASSSGPRS(1)PLDQR 160.46 0.0017277000000000002 15585000.0 2232.7 2691.1 2896.8 2902.3 3046.2 2217.2 2719.2 2309.0 1196.6 2037.2 True False 2284.717565922066 2376.024760941551 2503.430470983405 2395.4677879184137 2770.6717478502915 2194.896981056527 2514.08855475952 2247.757819310971 2030.5428037938614 2298.694464008418 0.9939196364261568 1.0336409636617325 1.0890662113563245 1.0420992547836236 1.2053240616496934 0.9548450285250649 1.0937027926606226 0.9778410547834946 0.8833461060558004 1.0 11.166599004501041 -7.924654997593813 5.041941262527258 0.9379356637236494 1.059711390900506 0.34035330126314456 0.06817253521592499 0.20884183907044424 9.521170621229158 0.03817022730727822 0.01750665088823324 1.1894467456251804e-08 7.924654997593813 0.12177572717685659 ASSSKES(ph)PSPSVR ddPTM_A459_Selumetinib_30min_R2 1 ASSSKESPSPSVR 13 1 H0Y517;H7C1U3;Q5T0F9-3;Q5T0F9-2;Q5T0F9 H0Y517 CC2D1B Coiled-coil and C2 domain-containing protein 1B 1 AS(0.086)S(0.286)S(0.11)KES(0.366)PS(0.151)PS(0.001)VR 128.64 0.0085725 2825500.0 9959.9 8176.4 8337.7 10150.0 8207.7 5889.5 7457.8 7836.1 5608.0 5308.7 True False 9406.368630638714 8803.503588730247 7801.261459401377 8767.552490273381 7176.575348231024 6700.725165442036 7804.602477350348 7858.90175366381 6729.756700612048 5155.424037340928 1.8245577012691943 1.7076196885001393 1.5132143162030027 1.7006462371998252 1.3920436604730904 1.2997427790436702 1.5138623750095668 1.5243948309084747 1.305374039432677 1.0 12.331875379842185 -1.522878771212772 0.047191925010392856 1.702635490476989e-11 4.145811433645956 0.7747374666423179 0.10869951480975357 283.08953200876834 1.0149292635640312 21.94012238365432 87.48969586956379 0.02999999820865094 1.522878771212772 4.145811433628929 ASSSKESPS(ph)PSVR ddPTM_A459_Selumetinib_30min_R2 1 ASSSKESPSPSVR 13 1 H0Y517;H7C1U3;Q5T0F9-3;Q5T0F9-2;Q5T0F9 H0Y517 CC2D1B Coiled-coil and C2 domain-containing protein 1B 1 AS(0.002)S(0.028)S(0.01)KES(0.32)PS(0.626)PS(0.014)VR 116.58 0.017819 0.0 3430.1 4403.2 4935.2 5122.0 4544.8 3516.1 3174.0 2742.5 3382.7 3526.8 True False 3239.4687737782374 4740.911281480485 4617.674605039476 4424.374764057165 3973.841592972494 4000.410859022115 3321.5972891616843 2750.480220954684 4059.3345205350174 3424.9721202731334 0.9458379980973093 1.3842189410588277 1.34823713679492 1.291798767606999 1.1602551651298083 1.1680126782179738 0.9698173218697017 0.8030664555410569 1.185216807023613 1.0 11.74187652905426 -7.045095731256866 2.1465727356799245 0.9728441732138648 1.2487791108892468 0.37403884490339967 0.14307249111595124 0.3119496170629879 2.8600852142298177 0.06283488795325547 0.04765870961890544 9.01372426754257e-08 7.045095731256866 0.2759349376753819 ASST(ph)PSSETQEEFVDDFR ddPTM_A459_Selumetinib_30min_R1 1 ASSTPSSETQEEFVDDFR 18 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0;F5H367;F5H270 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 AS(0.001)S(0.106)T(0.688)PS(0.062)S(0.037)ET(0.106)QEEFVDDFR 119.76 0.0022645 8456200.0 2264.9 2603.9 2699.6 2964.0 2788.8 2690.8 2812.0 2599.1 1546.4 2544.2 True False 2317.667763271772 2299.034177479733 2333.0091478413424 2446.3930411708557 2536.5535324026314 2663.7329950509215 2599.88857604581 2530.163424933366 2624.127855412693 2870.772852606622 0.8073323395013163 0.8008415487809291 0.8126763305996162 0.8521722779110038 0.8835786259088648 0.9278800977347577 0.9056406443599838 0.8813527070370658 0.9140841125866231 1.0 11.4872234677386 -1.5228787465319968 0.103647475668658 1.0552225369879362 0.25740577018819444 0.8784163005553125 0.020734206873099917 44.06750579301152 0.32318669767225255 0.26988541165580465 5.00653209333402 0.02999999991353844 1.5228787465319968 -0.7978167667997418 ASSTST(ph)PEPTR ddPTM_A459_Selumetinib_30min_R1 3 ASSTSTPEPTR 11 0 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 ASST(0.001)S(0.019)T(0.979)PEPTR;ASST(0.015)S(0.201)T(0.784)PEPTR;AS(0.002)S(0.009)T(0.043)S(0.218)T(0.728)PEPTR 197.73 2.8482e-05 72251000.0 14347.33 18165.29 18815.6 20338.399999999998 19153.920000000002 14522.599999999999 16938.8 15803.97 9323.850000000002 12883.37 True False 14681.59487395559 16038.489401985784 16260.544866692693 16786.680239051722 17421.451317899235 14376.515829465781 15661.092678493884 15384.797377070592 15821.892462939506 14537.076034150856 1.009941396706272 1.1032816616152912 1.1185567736244222 1.154749428263018 1.1984150923454162 0.9889551238290367 1.0773206827633328 1.0583144327599476 1.0883820395360337 1.0 13.827449496451916 -6.7719466241121555 24.999996860989466 1.0484095140213796 1.11841228185646 0.3268583278765589 0.053033783591907115 288.9270644653939 687442.125624331 0.019321649631644747 0.017208636872157363 1.690648703867492e-07 6.7719466241121555 0.0700027678350803 ASSTST(ph)PEPTR ddPTM_A459_Selumetinib_30min_R2 5 ASSTSTPEPTR 11 0 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 ASS(0.001)T(0.009)S(0.032)T(0.925)PEPT(0.032)R;ASST(0.006)S(0.032)T(0.962)PEPTR;ASS(0.007)T(0.012)S(0.029)T(0.951)PEPTR;ASST(0.001)S(0.029)T(0.967)PEPT(0.003)R;ASST(0.006)S(0.032)T(0.962)PEPTR 116.84 0.0135 433235300.0 119533.59999999999 105941.59999999999 121143.0 129317.09999999999 132523.4 77629.7 93581.79999999999 96000.2 72822.8 91822.2 True False 112890.40104291379 114066.98006406563 113348.79127052554 111703.88789555972 115874.62571777214 88322.48652274664 97933.53912881877 96279.54468831143 87389.39483903901 89171.05450327315 1.265998273450607 1.2791929028929299 1.2711388454687942 1.2526922387293231 1.2994645668737583 0.9904838180365427 1.0982660200034304 1.0797174624056662 0.9800197533363393 1.0 16.44428785761481 -6.758202780958545 24.99999998944871 1.0389652761238302 1.2726936086275165 0.9153351962810521 0.0370498306823059 23.143270315340512 178762.2790027226 0.012401711731214295 0.011911707620766408 1.7450071831988857e-07 6.758202780958545 0.2337283325036863 ASSVGVLS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 ASSVGVLSPQK 11 0 Q9UGU5 Q9UGU5 HMGXB4 HMG domain-containing protein 4 1 ASSVGVLS(1)PQK;ASSVGVLS(1)PQK 126.83 0.0030833 11995800.0 111689.0 87491.0 106553.0 113145.0 106234.0 94743.0 107335.0 113189.0 87375.0 91143.0 True False 105481.77250649172 94201.27837209517 99697.49598613463 97734.45581398818 92887.9351759902 107792.9882586765 112326.29018026758 113518.36125055226 104852.4414614797 88511.46477204676 1.1917300518994962 1.0642833514810992 1.1263794610437923 1.1042010892678638 1.049445237577015 1.2178421014304481 1.2690592170127761 1.2825272019043916 1.184619887734517 1.0 16.43357671721421 -6.779697163722197 24.952883148784203 1.2133582672689194 1.1057211958126139 0.18220511505239556 0.08183237192772574 299.28747505279847 409033.17159127194 0.027398700420600317 0.024209807945093576 1.6607445514109763e-07 6.779697163722197 -0.10763707145630552 ASSVGVLS(ph)PQKK ddPTM_A459_Selumetinib_30min_R1 1 ASSVGVLSPQKK 12 1 Q9UGU5 Q9UGU5 HMGXB4 HMG domain-containing protein 4 1 ASS(0.006)VGVLS(0.994)PQKK 138.87 0.002164 53326000.0 2661.3 3993.6 3652.4 4045.5 3043.8 3324.5 3554.7 2707.6 1570.3 2339.7 True False 2723.3031120116434 3526.0274554257276 3156.4241411971097 3339.0293684401813 2768.4888274265386 3291.058548404484 3286.5661170946114 2635.7856524756976 2664.684409825759 2640.0232856079383 1.0315451105517532 1.3356046799465113 1.1956046593999097 1.2647726959996406 1.0486607608800003 1.2466020911048998 1.2449004275876259 0.9983948500926707 1.0093412525382865 1.0 11.366334939201476 -7.768713325235799 24.991055347631733 1.002900956526983 1.199781393861264 0.49936395253726096 0.08839020918611483 135.590012189314 465836.4646958005 0.045282830198099054 0.02245157936198226 1.7032824622931738e-08 7.768713325235799 0.19688043733428096 ASSVGVLS(ph)PQKK ddPTM_A459_Selumetinib_30min_R2 1 ASSVGVLSPQKK 12 1 Q9UGU5 Q9UGU5 HMGXB4 HMG domain-containing protein 4 1 ASS(0.002)VGVLS(0.998)PQKK 104.95 0.017106 17115000.0 13375.0 13819.0 14864.0 14074.0 15547.0 11312.0 13195.0 13598.0 10441.0 15053.0 True False 12631.671044367195 14878.872864911604 13907.666422699549 12157.096920995817 13593.846868056538 12870.125319887999 13808.593645396477 13637.567928729908 12529.491745914838 14618.380777609022 0.8640950893627788 1.0178194898098138 0.9513821424053973 0.8316308834708181 0.9299146789826571 0.8804070379396036 0.9446048680403171 0.9329055068546699 0.85710530711488 1.0 13.835495897851692 -10.217521636984843 4.7417828210042385 1.0000000472764086 0.915242930186031 0.19998574327910668 0.052362144855254346 71534879.46704109 198842633.627971 75.20259401674294 0.013040749306294836 6.060080078507519e-11 10.217521636984843 -0.08475711709037759 ASSVSTKES(ph)PAR ddPTM_A459_Selumetinib_30min_R1 6 ASSVSTKESPAR 12 1 E7ETY2;Q13428-6;Q13428-7;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4 E7ETY2;Q13428 TCOF1 Treacle protein 1 ASSVSTKES(1)PAR;ASSVS(0.007)T(0.001)KES(0.991)PAR;ASSVS(0.001)T(0.001)KES(0.998)PAR;ASSVSTKES(1)PAR;ASSVS(0.002)T(0.001)KES(0.997)PAR;ASSVST(0.001)KES(0.999)PAR 255.39 1.7038999999999997e-18 586175000.0 31897.7 37626.1 39460.1 41883.0 37757.49999999999 32037.7 31988.0 33036.7 20394.1 28325.5 True False 32640.854347880282 33220.81872010065 34101.63515881398 34568.920291281705 34342.34079162804 31715.42982590418 29575.119406313468 32160.45939767462 34607.29817386961 31961.35383873475 1.0212600665345417 1.039405867715138 1.0669646639775743 1.0815849812152445 1.0744958103122564 0.9923055821079603 0.9253400076710973 1.0062295721246504 1.0827857401937766 1.0 14.96404089967583 -6.768462400978422 24.96917825036464 0.9969720070042996 1.0577272057436808 0.3324345649269489 0.03900387570793472 194.0278437129055 689828.7055355456 0.014610466006774491 0.013152571242394434 1.7042668597411633e-07 6.768462400978422 0.06075519873938129 ASSVSTKES(ph)PAR ddPTM_A459_Selumetinib_30min_R2 4 ASSVSTKESPAR 12 1 E7ETY2;Q13428-6;Q13428-7;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4 E7ETY2;Q13428 TCOF1 Treacle protein 1 ASSVSTKES(0.999)PAR;ASSVS(0.005)T(0.005)KES(0.989)PAR;ASSVST(0.001)KES(0.998)PAR;ASSVS(0.259)T(0.074)KES(0.668)PAR 181.75 0.0004943 187475000.0 66650.8 62825.4 67883.2 74087.2 73294.0 54898.0 66031.4 58747.5 46264.4 75251.4 True False 62946.61536029231 67643.90616449957 63515.66881763986 63996.395552451446 64086.15246332642 62459.70118557379 69101.99093873685 58918.445498827816 55518.57273534167 73078.69655538225 0.8613538326123344 0.9256309889604564 0.8691406909468464 0.8757188971474356 0.8769471198047315 0.8546909582362224 0.9455832437619947 0.8062328459043714 0.7597094003074789 1.0 16.157163281579216 -7.7852256161429745 24.999995269602817 0.8372283640616435 0.8857433354406274 0.026747285477063953 0.06375655251977219 543.4272605515129 571148.4836251424 0.03258591440504434 0.015668045033371186 1.6397377075527316e-08 7.7852256161429745 0.04851497137898397 ASSVSTKES(ph)PARK ddPTM_A459_Selumetinib_30min_R1 1 ASSVSTKESPARK 13 2 E7ETY2;Q13428-6;Q13428-7;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4 E7ETY2;Q13428 TCOF1 Treacle protein 1 ASSVST(0.009)KES(0.991)PARK 191.63 0.0056465000000000005 16402000.0 2154.7 2078.4 2967.7 2465.9 2322.8 2358.1 2187.2 1927.7 1897.1 1810.8 True False 2204.900317683646 1835.059961778054 2564.7026404092276 2035.2768556758485 2112.7031501236484 2334.3796549834915 2022.2177430751772 1876.5711339479237 3219.2401412981244 2043.2338186856668 1.0791228578538177 0.8981154995557371 1.2552173994746236 0.9961057011992211 1.0339996973438255 1.14249266708257 0.9897143070860052 0.9184319076879068 1.5755613047599892 1.0 10.996638593851346 -8.233360539051798 24.98580597792725 1.287781060058499 1.04184151517937 0.27284444151240683 0.16230925111052405 760.1673430831167 676433.0024142781 0.1010507092479657 0.038176633839683574 5.84304809339349e-09 8.233360539051798 -0.24593954487912884 AST(ph)PDWVSEGPQPGLR ddPTM_A459_Selumetinib_30min_R1 4 ASTPDWVSEGPQPGLR 16 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 AS(0.058)T(0.942)PDWVSEGPQPGLR;AST(1)PDWVSEGPQPGLR;AS(0.067)T(0.933)PDWVSEGPQPGLR;AS(0.048)T(0.952)PDWVSEGPQPGLR 365.28 9.488499999999992e-197 582796000.0 8461.9 10423.5 9100.1 9465.9 10011.0 7909.3 9399.3 9522.2 4587.74 7501.200000000001 True False 8659.04580600883 9203.111774246312 7864.356403271231 7812.858261949802 9105.5068175856 7829.73962306982 8690.30323358015 9269.640323535265 7785.059704727769 8464.052087875483 1.0230378684002512 1.0873174785194801 0.9291479213055294 0.9230635847741889 1.075785772943078 0.9250580622354276 1.0267308309726455 1.095177608466489 0.9197792763916999 1.0 13.04713279050349 AST(ph)PDWVSEGPQPGLR ddPTM_A459_Selumetinib_30min_R2 2 ASTPDWVSEGPQPGLR 16 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 AS(0.005)T(0.995)PDWVSEGPQPGLR;AS(0.06)T(0.94)PDWVSEGPQPGLR 312.67 8.687199999999997e-102 236698000.0 60286.0 51913.0 57468.0 62699.0 56013.0 43451.0 58117.0 48273.0 41241.0 46973.0 True False 56935.54546397914 55894.56017339579 53770.57144642747 54159.288038192164 48976.14617742656 49435.98084109382 60819.555656650766 48413.466437974625 49490.3523698184 45616.767439489 1.2481275780776135 1.2253073444439122 1.178745765309972 1.1872671186101664 1.0736435071247388 1.0837238939973342 1.3332719320221098 1.061308574795342 1.0849158138061348 1.0 15.477276595505638 -1.8839254168485033 0.021036976346492247 1.4086462644554685e-06 2.618771254348188 0.40372175593262116 0.07560877959710577 2908.147821647152 5.0150703295700705 232.0528662695469 416.9108972410982 0.013063952214144225 1.8839254168485033 2.6187698457019235 AST(ph)PDWVSEGPQPGLRR ddPTM_A459_Selumetinib_30min_R2 1 ASTPDWVSEGPQPGLRR 17 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 AST(1)PDWVSEGPQPGLRR 212.03 1.3172e-29 0.0 17881.0 20876.0 22252.0 25796.0 21116.0 13432.0 9640.7 10429.0 8122.3 18661.0 True False 16887.245603314386 22477.122073080172 20820.330546145735 22282.54029941793 18463.21930056485 15282.136076444085 10089.011652684634 10459.3466633861 9746.98695602376 18122.208442899206 0.9318536234987015 1.2403081083579162 1.1488848399326148 1.2295709085141255 1.0188172903286112 0.8432822150013433 0.5567208701121521 0.5771562939661677 0.5378476352225662 1.0 14.145471158083433 -6.849705103223524 2.224140312765198 0.6347675547280629 1.1428583616624202 0.6672574493219295 0.14900186973604798 0.16113194644412637 1.6310159994618407 0.057262524496787176 0.049846064499768 1.41349701853457e-07 6.849705103223524 0.5080908069343573 AST(ph)PVLK ddPTM_A459_Selumetinib_30min_R1 1 ASTPVLK 7 0 A0A669KBK8;Q04724;F6T2C8;A0A669KAE5 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 AS(0.041)T(0.959)PVLK 124.08 0.015861 11194000.0 16732.0 17775.0 18394.0 20604.0 17216.0 13668.0 16348.0 14639.0 8569.1 14482.0 True False 17121.823045195495 15693.894736626684 15896.195831009656 17005.898184981215 15658.81583973166 13530.512329551058 15114.857198149692 14250.726165826467 14541.136837698466 16340.90576662571 1.04778910604605 0.9604054365627352 0.972785478236811 1.040694954603659 0.9582587442437166 0.8280148311720557 0.9249705869438356 0.8720891221912449 0.8898611279796343 1.0 13.996200332971993 -6.530182140630485 24.019370771098217 0.8960077642251617 0.9998231024150253 0.498815215893861 0.048106322898892204 84.78630497209076 278841.10850650776 0.014905221124446354 0.01494034972120051 2.949971765847039e-07 6.530182140630485 0.10381533818986355 AST(ph)PYIEK ddPTM_A459_Selumetinib_30min_R1 2 ASTPYIEK 8 0 C9J618;C9J5A2;C9J347;C9J7P5;C9IZN7;Q969Z0-2;Q969Z0 C9J618 TBRG4 Protein TBRG4 1 AS(0.065)T(0.935)PYIEK;AS(0.057)T(0.943)PYIEK 142.0 0.0052452 68500000.0 12765.900000000001 18101.6 16744.9 19057.6 14903.2 16791.4 16004.8 14103.1 7266.299999999999 11420.8 True False 13063.320631882689 15982.256256794462 14471.034553151761 15729.547915458055 13555.208191373666 16622.493761371363 14797.545050461596 13729.039974674994 12330.380390445718 12886.770928012622 1.013700073110347 1.240206436978951 1.1229372070000365 1.2205965329348678 1.051870035332748 1.2898882004054415 1.1482740814687276 1.06535920063819 0.9568246738709811 1.0 13.653603188652529 -7.955899174584805 2.8962077893596305 0.9813670580159971 1.161232630952188 0.4460220586387158 0.07925147065453907 0.22880753984766716 3.7672737243534606 0.0534067263395023 0.02029873850961213 1.1068807265818332e-08 7.955899174584805 0.179865572936191 AST(ph)PYIEK ddPTM_A459_Selumetinib_30min_R2 2 ASTPYIEK 8 0 C9J618;C9J5A2;C9J347;C9J7P5;C9IZN7;Q969Z0-2;Q969Z0 C9J618 TBRG4 Protein TBRG4 1 AS(0.001)T(0.999)PYIEK;AS(0.003)T(0.997)PYIEK 145.9 0.004504600000000001 16356400.0 310230.0 256260.0 268800.0 313860.0 269560.0 216290.0 318420.0 274800.0 206140.0 255110.0 True False 292988.6585490866 275914.3179942285 251505.70064731152 271111.7265613001 235695.46290302428 246081.98421486697 333227.1609372597 275599.6225044107 247373.7600328398 247744.31144461746 1.182625170445471 1.1137059671939566 1.0151825451844327 1.0943206928967424 0.9513657913219667 0.9932901497513411 1.345044651052469 1.1124357241438425 0.998504299010472 1.0 17.918492405935922 AST(ph)VSPGGYMVPK ddPTM_A459_Selumetinib_30min_R2 1 ASTVSPGGYMVPK 13 0 Q5TGY3 Q5TGY3 AHDC1 AT-hook DNA-binding motif-containing protein 1 1 AS(0.025)T(0.9)VS(0.068)PGGY(0.007)MVPK 92.781 0.04208 4623600.0 28184.0 23379.0 28044.0 32049.0 31117.0 22777.0 25458.0 26624.0 25632.0 26257.0 True False 26617.64610949122 25172.094124666644 26239.67957199852 27683.87091239129 27207.80427049048 25914.32500098028 26641.847444069976 26701.47143215954 30759.116217918698 25498.89218612102 1.0438746089518012 0.9871838329654082 1.0290517478355672 1.0856891628985963 1.06701907172656 1.0162921907284028 1.0448237221290368 1.047162019324631 1.2062922574597499 1.0 14.638146949288206 -8.036387425765609 24.9222326486441 1.1110064960692407 1.0392508600336714 0.18480349094396054 0.052653529403790596 794.725924187428 544313.4007958781 0.03343490485617338 0.012645614402660507 9.19628822511462e-09 8.036387425765609 -0.07175563603556934 ASTAPGAEAS(ph)PSPCITER ddPTM_A459_Selumetinib_30min_R1 4 ASTAPGAEASPSPCITER 18 0 Q66PJ3 Q66PJ3 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 ASTAPGAEAS(0.985)PS(0.015)PCITER;AS(0.006)T(0.001)APGAEAS(0.993)PS(0.001)PCITER;ASTAPGAEAS(1)PSPCITER;AST(0.008)APGAEAS(0.898)PS(0.094)PCITER 251.0 1.7379999999999993e-79 29986900.0 9817.9 11256.8 10569.8 11856.800000000001 10815.0 9797.6 10466.8 10045.8 5591.7 9191.7 True False 10046.637967692146 9938.84862285566 9134.479215755453 9786.23245970128 9836.785159543339 9699.045039509036 9677.280849130977 9779.352750642764 9488.706498390558 10371.54422973992 0.9686732992840044 0.958280503144023 0.8807250890916282 0.94356561018558 0.9484397830881167 0.9351592033612001 0.933060751106072 0.9429022847534049 0.9148788539301731 1.0 13.340343094021314 -11.392364887784831 2.715999025413967 1.0283479757195944 0.9358585104915593 0.40714813250036863 0.023097652294342335 13711595.098761616 8657930.54435833 2503141.4158341954 0.005877854918592431 4.051679762754004e-12 11.392364887784831 -0.09248946522803503 ASTAPGAEAS(ph)PSPCITER ddPTM_A459_Selumetinib_30min_R2 4 ASTAPGAEASPSPCITER 18 0 Q66PJ3 Q66PJ3 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 ASTAPGAEAS(0.984)PS(0.016)PCITER;ASTAPGAEAS(0.993)PS(0.007)PCITER;AS(0.022)T(0.022)APGAEAS(0.86)PS(0.082)PCIT(0.015)ER;ASTAPGAEAS(0.661)PS(0.203)PCIT(0.136)ER 156.06 2.4502e-05 58922800.0 95343.0 85181.2 94465.0 112410.0 103985.0 83203.0 82257.1 95214.0 80229.0 98532.0 True False 90044.21774826926 91714.3241392725 88387.22474571514 97099.5640819342 90921.47466230518 94663.45800836633 86082.21813935152 95491.05697647388 96277.04178555716 95687.12514311919 0.9410275166443779 0.9584813422087395 0.9237107355196889 1.0147610134247675 0.9501954889575162 0.9893019344742382 0.8996217412802232 0.9979509451626637 1.006165057645484 1.0 16.546037200376404 -1.522878746060359 0.04640444380696657 1.0897859814399136 0.7497893098920393 0.18653160211441455 0.033492991871146405 1036.8369523848444 3.6578064181256904 6.673634336932118 26.015380848225334 0.029999999946118027 1.522878746060359 -0.3399966715478743 ASTAS(ph)PCNNNINAATAVALQEPR ddPTM_A459_Selumetinib_30min_R1 1 ASTASPCNNNINAATAVALQEPR 23 0 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4 Q71RC2-6 LARP4 La-related protein 4 1 AS(0.035)T(0.2)AS(0.765)PCNNNINAATAVALQEPR 149.29 6.2272e-08 49656000.0 1308.0 1485.8 1540.4 1498.8 1327.4 1305.3 1214.5 1360.4 782.06 938.27 True False 1338.4738550750492 1311.841845270319 1331.2221408115292 1237.0627159604858 1207.3369043715045 1292.1698671175743 1122.8892872004399 1324.3177727980274 1327.0987005975499 1058.7060940237468 1.264254416433941 1.2390991727312135 1.257404815487602 1.1684666055513784 1.1403891138312687 1.220518021395833 1.06062418412343 1.2508833001657615 1.253510023309437 1.0 10.048086424941973 -14.344578288293727 0.2393404280777206 1.746396118560402e-29 1.2223226783631336 0.48407513158162485 0.06290639765036574 146.68283523810254 1.5811518700267875 71.7515302647253 0.10472106839107292 4.52294921831976e-15 14.344578288293727 1.2223226783631336 ASTAS(ph)PCNNNINAATAVALQEPR ddPTM_A459_Selumetinib_30min_R2 4 ASTASPCNNNINAATAVALQEPR 23 0 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4 Q71RC2-6 LARP4 La-related protein 4 1 AS(0.014)T(0.055)AS(0.932)PCNNNINAATAVALQEPR;AS(0.041)T(0.081)AS(0.878)PCNNNINAATAVALQEPR;AS(0.066)T(0.055)AS(0.879)PCNNNINAATAVALQEPR;AS(0.024)T(0.078)AS(0.898)PCNNNINAATAVALQEPR 166.08 2.5387e-12 77284000.0 115200.0 106472.0 114369.0 119395.0 137114.0 96219.0 94191.0 93997.0 98105.0 108656.0 True False 108797.6451821383 114638.06003856071 107010.62305555178 103133.19503213673 119888.51350528761 109472.29386088238 98571.06813592579 94270.51570795898 117728.74128272924 105518.81895780806 1.0310733787272701 1.0864228880764766 1.014137801318078 0.9773914838202915 1.1361813436636863 1.0374670124450038 0.934156287091686 0.8934000270193818 1.1157132201205109 1.0 16.68714079655315 -7.113954161834518 7.236735078605594 0.9773282429086908 1.049182803822347 0.16630606019077443 0.06652133164854598 0.4311532775168212 24.592513337760767 0.025350110567186508 0.019628763758053926 7.692116234249609e-08 7.113954161834518 0.07185456091365616 ASTNS(ph)ETNRGESEK ddPTM_A459_Selumetinib_30min_R1 2 ASTNSETNRGESEK 14 1 J3QKN5;J3KS94;J3QQK6;P02686-2;P02686 J3QKN5 MBP Myelin basic protein 1 AST(0.007)NS(0.992)ETNRGESEK;AST(0.002)NS(0.998)ETNRGESEK 199.33 0.00039479 21082800.0 4228.1 4763.7 5106.6 5175.299999999999 4236.6 4120.6 4136.4 4303.5 2504.9 3113.5 True False 4326.606503549553 4205.9637894159505 4413.151768545935 4271.531007412798 3853.400278032483 4079.150505205454 3824.388017765255 4189.357200261913 4250.632349342507 3513.1480530582203 1.231546874258035 1.1972065298399905 1.2561815505339307 1.215869910092289 1.0968510919083159 1.16110976355082 1.0885928973121695 1.192479547400528 1.2099212117298335 1.0 11.778548661368141 -14.522878745280334 0.11064453228183381 0.46255761332432044 1.2767507108148388 0.5619395150109128 0.04990937654017767 138.10022967240204 1.0105053593531501 17.10579083508071 0.6643773606605645 3.000000000000026e-15 14.522878745280334 0.8141930974905184 ASTSDYQVISDRQT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ASTSDYQVISDRQTPK 16 1 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 ASTSDYQVISDRQT(1)PK 180.93 1.0277e-05 20488000.0 5043.6 5671.9 5867.6 5581.0 4927.2 5269.8 4523.5 4907.8 3343.9 4530.9 True False 5161.106066862779 5007.831311205228 5070.812148419717 4606.383118344986 4481.5356299678115 5216.790596595564 4182.288753109255 4777.629201218873 5674.354071207001 5112.4851497033815 1.0095102314697615 0.9795297520807028 0.9918487780280238 0.9010066500852801 0.8765865325257371 1.020402102663953 0.8180539660544354 0.9345023137125521 1.1099013307718297 1.0 12.31980903210906 -8.244876410759526 24.324436126281185 1.0549506598781833 0.9393916175024809 0.32868064054405266 0.06484281944756642 567.4553002743661 833371.3826393568 0.04432945111404844 0.016638894657517632 5.690148350561429e-09 8.244876410759526 -0.11555904237570236 ASTSSSSSSSSNQQTEKETNT(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965-3;P51965 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 ASTSSSSSSSSNQQTEKET(0.03)NT(0.97)PK;ASTSSSSSSSSNQQTEKET(0.015)NT(0.985)PK;ASTSSSSSSSSNQQT(0.001)EKET(0.153)NT(0.846)PK;ASTSSSSS(0.002)S(0.007)S(0.007)S(0.002)NQQT(0.004)EKET(0.133)NT(0.845)PK 90.166 0.0002416 84493000.0 6147.1900000000005 6185.74 8975.92 8350.060000000001 5690.17 6599.0599999999995 4982.51 5452.290000000001 3599.33 5102.6 True False 6290.407566650451 5461.510685127493 7757.039365199316 6891.878771038842 5175.495128181107 6532.679447867079 4606.675259258187 5307.677557666092 6107.8001253379225 5757.568413532963 1.0925458656930709 0.9485793815824062 1.3472769766776314 1.1970120502328245 0.8989029320114177 1.1346247197883477 0.8001077761282624 0.9218609622059517 1.0608297959572226 1.0 12.491243933412008 -6.258373439133615 24.975310036531646 0.9652785997589669 1.1465785163253455 0.3227075861294697 0.1255119703559344 340.52082929102113 2773894.724726656 0.038835493082365065 0.04798601633074263 5.51602925522237e-07 6.258373439133615 0.18129991656637856 ASTSSSSSSSSNQQTEKETNT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965-3;P51965 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 ASTSSSSSSSSNQQTEKET(0.025)NT(0.975)PK;ASTSSSSS(0.001)S(0.003)S(0.003)S(0.003)NQQT(0.016)EKET(0.421)NT(0.552)PK 86.98200000000001 0.00033591 33928000.0 22830.2 28017.0 23580.8 21871.0 17890.1 13306.400000000001 18902.8 15007.3 11171.6 24895.0 True False 21561.388880531737 30165.81381114616 22063.637000833794 18892.132070420597 15642.585698476765 15139.235816527378 19781.817655187602 15050.968758407746 13406.23216058444 24176.216665022013 0.8918429702744436 1.2477474961907442 0.9126174416179565 0.7814345946755848 0.6470237223307298 0.6262036788589309 0.8182346282413907 0.6225526916369585 0.554521509561936 1.0 14.561300874522544 -5.679987569700688 2.6041882526699465 0.6966868146307013 1.0721625577134895 0.4837151540739376 0.14488360594132935 0.2004280057100538 2.7465485676911103 0.03971412184644115 0.07697796106390241 2.08935593117158e-06 5.679987569700688 0.3754757430827882 ASTVS(ph)PGGYMVPK ddPTM_A459_Selumetinib_30min_R2 2 ASTVSPGGYMVPK 13 0 Q5TGY3 Q5TGY3 AHDC1 AT-hook DNA-binding motif-containing protein 1 1 ASTVS(1)PGGYMVPK;AS(0.003)T(0.482)VS(0.515)PGGYMVPK 139.48 0.00093275 7732700.0 44742.0 41050.0 51762.0 55663.0 54637.0 42784.0 41952.0 46387.0 41533.0 44889.0 True False 42255.41875641696 44198.40300344607 48431.68927420441 48081.603375969135 47773.011599022655 48677.10764551698 43902.85112631097 46521.97849021875 49840.760528980034 43592.93793437129 0.9693179849459114 1.0138890631777628 1.110998514188647 1.1029677203301937 1.0958887806769164 1.1166282877928497 1.0071092522464589 1.0671907124098197 1.1433218977811217 1.0 15.411806816563612 -5.05937392372751 3.919443848709404 1.0826949178334864 0.975821351296533 0.41256051472295896 0.04376693132589959 0.19748533062409557 5.957020337923425 0.011183581478033958 0.03861861523743277 8.72220071197854e-06 5.05937392372751 -0.10687356653695335 ASVALT(ph)PTAPSR ddPTM_A459_Selumetinib_30min_R1 1 ASVALTPTAPSR 12 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7;H7BZ26 E9PHV5 SSFA2 Sperm-specific antigen 2 1 ASVALT(0.991)PT(0.009)APSR 154.67 0.0010195 23077000.0 2337.7 2889.1 3458.9 3551.5 3531.4 2470.5 2637.6 2546.3 1488.5 2888.1 True False 2392.16386162763 2550.8428288938476 2989.200378377693 2931.2971949117054 3211.985493519309 2445.6490130345264 2438.643708456056 2478.763852451937 2525.8757842613772 3258.815767476294 0.7340592510635174 0.7827514689083765 0.9172658387781776 0.8994976715672924 0.9856296650997085 0.7504717012365804 0.7483220539173349 0.7606333187627701 0.7750900831738263 1.0 11.670132078327626 ASVALT(ph)PTAPSR ddPTM_A459_Selumetinib_30min_R2 2 ASVALTPTAPSR 12 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7;H7BZ26 E9PHV5 SSFA2 Sperm-specific antigen 2 1 AS(0.028)VALT(0.971)PT(0.001)APSR;AS(0.002)VALT(0.989)PT(0.009)APSR 160.86 0.0011083 73533000.0 452590.0 418970.0 450790.0 469090.0 453580.0 297160.0 357040.0 341950.0 261550.0 389080.0 True False 427436.85966132005 451103.6517991192 421786.66218304087 405199.1327746151 396597.22534335166 338091.0926500991 373643.0674613385 342945.01788713 313867.3083175969 377846.2494487552 1.1312454742766753 1.193881512539135 1.116291779522467 1.072391570290205 1.0496259415620839 0.8947848315110831 0.9888759462518186 0.9076311287658855 0.8306746693278073 1.0 18.527439776921703 -6.332044769343592 1.0277957447629804 0.9131732839892679 1.1637894484494322 0.7800489262636179 0.05158928295225849 0.22805739697961125 0.5097875148785287 0.02339094892866865 0.03335959980911979 4.655381009503044e-07 6.332044769343592 0.2506161644601643 ASVALTPTAPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 ASVALTPTAPSR 12 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7;H7BZ26 E9PHV5 SSFA2 Sperm-specific antigen 2 1 ASVALTPTAPS(1)R 117.27 0.004808 9517800.0 1070.7 1480.3 987.55 1139.8 1385.8 1043.4 1641.5 1826.2 934.04 1074.1 True False 1095.6452267804696 1306.985787827201 853.4461342238543 940.7553266958641 1260.4546346828615 1032.9043433314007 1517.6803334207689 1777.7632436663891 1584.9976604175313 1211.9711976199878 0.9040191952845466 1.0783967394553586 0.7041802114603151 0.7762192109377478 1.0400037865240388 0.852251559574823 1.2522412549086301 1.466836214554832 1.3077849238744907 1.0 10.24313969837018 -7.304443110253156 5.465859628462588 1.3005130924996018 0.8934898307996302 0.5791505851780127 0.15048297398315816 0.1366413154237216 10.444421233079863 0.06330448881580662 0.04291128378129536 4.960859071607786e-08 7.304443110253156 -0.4070232616999716 ASVGMYLIS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 ASVGMYLISK 10 0 F8WEJ5;P08243-3;P08243-2;P08243 F8WEJ5 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 ASVGMYLIS(1)K;AS(0.001)VGMYLIS(0.999)K 94.114 0.025909 9197500.0 7686.1 10190.0 9605.2 10459.7 9519.6 10467.4 10038.3 10379.9 8122.200000000001 9677.6 True False 7865.171175452852 8996.95006279752 8300.86659758693 8633.10974788624 8658.553860821887 10362.107459638773 9281.102949118298 10104.591333333017 13782.780177983035 10919.814227806728 0.720266023887532 0.8239105423503692 0.7601655508432748 0.7905912653625996 0.7929213519744079 0.9489270827751095 0.8499323116216081 0.9253446187392282 1.2621808293117218 1.0 13.414660692318046 -8.033110308329716 3.7175581275957743 1.1301781405458515 0.8162065752240648 0.6977146783290173 0.08269401574597565 0.1253574090972677 3.5795756673625148 0.05901409655861154 0.021758651070015775 9.265944437664548e-09 8.033110308329716 -0.3139715653217867 ASVGS(ph)PSSGEGHLAEPALSAYR ddPTM_A459_Selumetinib_30min_R1 1 ASVGSPSSGEGHLAEPALSAYR 22 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 AS(0.202)VGS(0.784)PS(0.014)SGEGHLAEPALSAYR 101.58 7.6761e-05 6355500.0 1314.3 1355.6 1340.2 1244.3 1560.6 1120.5 1343.9 1152.5 452.35 967.44 True False 1344.9206328173823 1196.8857217986579 1158.2082011916466 1027.0063634038113 1419.444005546308 1109.2287873325997 1242.5285410199021 1121.931956152401 767.6049116631735 1091.6203476636076 1.2320406409571905 1.0964303884224487 1.0609990952170842 0.940809106024737 1.3003092225097679 1.016130552812321 1.1382423785698783 1.0277675370871102 0.7031793730357596 1.0 10.09225547628838 -8.053304994456544 6.455404222830153 0.8525675061664666 1.1051595434620913 0.43690012724521865 0.1167782909336582 0.2070060803964809 19.414373204984056 0.075075794459418 0.028449217478316257 8.844942328705262e-09 8.053304994456544 0.25259203729562474 ASVGS(ph)PSSGEGHLAEPALSAYR ddPTM_A459_Selumetinib_30min_R2 2 ASVGSPSSGEGHLAEPALSAYR 22 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 AS(0.009)VGS(0.591)PS(0.233)S(0.167)GEGHLAEPALSAYR;AS(0.16)VGS(0.632)PS(0.164)S(0.045)GEGHLAEPALSAYR 66.308 0.004254600000000001 16737700.0 26744.0 22975.0 40359.0 41144.0 50968.0 31071.0 25832.0 25341.0 33879.0 37995.0 True False 25257.675544714486 24737.10862373139 37762.3458795567 35540.116222641176 44564.94418029881 35350.74821554455 27033.239185136918 25414.73811457162 40655.74665835157 36897.98562713441 0.6845272205358616 0.6704189457307385 1.0234256758934461 0.963199362203267 1.2077879977146013 0.9580671577244032 0.7326481032952905 0.6887838911152341 1.1018419018639798 1.0 15.171254436890152 -5.252400829576412 24.25569326988759 0.9492053140899599 0.6774730154304375 0.37203257787127675 0.1460622945401908 515.589981354555 1383615.8149374898 0.040792928425971514 0.10447825668501855 5.592412147939324e-06 5.252400829576412 -0.2717322986595224 ASVGSPS(ph)SGEGHLAEPALSAYR ddPTM_A459_Selumetinib_30min_R1 1 ASVGSPSSGEGHLAEPALSAYR 22 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 AS(0.001)VGS(0.389)PS(0.607)S(0.004)GEGHLAEPALSAYR 146.68 4.18e-07 5151700.0 399.54 506.03 518.16 461.44 738.33 593.24 612.9 453.91 275.01 368.7 True False 408.84850463049315 446.78377235303554 447.79671804914454 380.8581663015786 671.5481818627493 587.2725442188231 566.6684595513789 441.8708322925261 466.6718840643073 416.0262364421282 0.9827469251145811 1.0739317216480069 1.0763665337040247 0.9154667012318544 1.6141967093370222 1.4116238178659106 1.362097891704015 1.0621225143669346 1.1217366675123726 1.0 8.700530703697325 -6.210173210948891 24.99973769830071 1.2775599749284805 1.0211309634647718 0.32698623723105724 0.17454376812611386 443.0941425841811 216072.74452258108 0.054401954840970636 0.07023253672145713 6.163491324922989e-07 6.210173210948891 -0.25642901146370867 ASVLDTSMSAGS(ph)GSPSK ddPTM_A459_Selumetinib_30min_R1 1 ASVLDTSMSAGSGSPSK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 ASVLDTSMSAGS(0.995)GS(0.005)PSK 177.07 3.4545e-07 9335500.0 4177.2 4357.2 4166.4 4195.5 4232.2 3553.9 4121.5 3746.5 2254.8 3272.2 True False 4274.520632583709 3847.0569983926766 3600.6257643970107 3462.8346842889086 3849.398257255599 3518.150992683021 3810.6119367613132 3647.130649652904 3826.2309159237834 3692.2187439271247 1.1577105607879654 1.041936370839411 0.9751929704379612 0.9378736538793911 1.0425704770571895 0.95285551498529 1.0320655955254328 0.987788346953067 1.036295837622589 1.0 11.850272312031061 -4.813436133099985 2.8358913591780834 0.9948507201532576 1.1806713312770425 0.6863315110350741 0.03310374338628316 0.2094706340844361 2.470829192312101 0.008247769086869786 0.08843578224999869 1.5366107491137703e-05 4.813436133099985 0.1858206111237849 ASVLDTSMSAGS(ph)GSPSK ddPTM_A459_Selumetinib_30min_R2 1 ASVLDTSMSAGSGSPSK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 ASVLDTSMSAGS(0.978)GS(0.022)PSK 177.66 8.8712e-08 48416000.0 97002.0 96458.0 102710.0 101240.0 100610.0 76505.0 97285.0 88287.0 67613.0 112350.0 True False 91611.01716977247 103856.01843864575 96101.75042219253 87450.93735125876 87970.47233518807 87042.86930675665 101808.94526657034 88543.90055330026 81137.48926506448 109106.16357964341 0.83965024673331 0.9518803982401485 0.880809546126529 0.801521513378324 0.8062832515504307 0.7977814126258652 0.9331181844026036 0.8115389419651488 0.7436563307061672 1.0 16.735373078523764 -5.5760131359694896 7.354200349681045 0.8348669513059094 0.9008323541793837 0.07873200918767764 0.07446065285089866 0.4273708898431363 49.03585935847561 0.019475780727505217 0.034024086781465804 2.654525270164881e-06 5.5760131359694896 0.0659654028734743 ASVLDTSMSAGSGS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 ASVLDTSMSAGSGSPSK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 ASVLDTSMSAGS(0.012)GS(0.98)PS(0.007)K;ASVLDTSMSAGS(0.018)GS(0.974)PS(0.008)K;ASVLDTSMS(0.003)AGS(0.09)GS(0.905)PS(0.002)K 191.36 7.8615e-08 70138000.0 7962.9 8659.3 8825.6 8864.2 7908.500000000001 7588.7 8123.400000000001 7607.1 4267.66 7008.7 True False 8148.420076893817 7645.465130400647 7627.131995550655 7316.233871641937 7193.177571359076 7512.3645679883075 7510.64539781314 7405.334996656772 7241.90732244602 7908.334915519233 1.0303584969452222 0.9667604131682975 0.9644422090145995 0.9251294930977996 0.9095691631930333 0.9499299976846103 0.9497126105615898 0.936396229517875 0.9157309850692562 1.0 12.94915825470838 -4.4919335263790625 1.2433682836365703 0.9387980456647512 1.128614067181307 0.5323834645586918 0.024492965886494432 1.9497749638664492 1.6317250988973115 0.0070217538696386965 0.5642360864200191 3.2215618495700004e-05 4.4919335263790625 0.18981602151655574 ASVLDTSMSAGSGS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 5 ASVLDTSMSAGSGSPSK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 ASVLDTSMSAGS(0.098)GS(0.867)PS(0.035)K;ASVLDTSMSAGS(0.017)GS(0.637)PS(0.345)K;ASVLDTSMSAGS(0.002)GS(0.998)PSK;ASVLDTS(0.003)MS(0.037)AGS(0.237)GS(0.719)PS(0.004)K;ASVLDTS(0.001)MS(0.005)AGS(0.097)GS(0.883)PS(0.014)K 265.08 7.650499999999998e-41 94924500.0 354341.0 338218.0 351099.0 381143.0 376306.0 269252.0 325410.0 309662.0 222429.0 344634.0 True False 334648.1457594107 364158.23305772385 328509.6725876883 329230.6658916519 329031.07606167626 306339.0189736987 340542.20978768263 310563.06515269604 266921.0151855278 334683.520953332 0.9998943025523918 1.0880674137179935 0.9815531749275921 0.9837074288983577 0.9831110749774742 0.9153095381006655 1.0175051607490635 0.9279305544177082 0.7975325896692327 1.0 18.35243799222495 -6.192848521170482 0.6087977873253249 0.917660050512065 1.0499564151905005 0.3101732093354027 0.06045788939334967 1.2144407342436188 0.917473779400401 0.0418681236032471 0.08992280163493135 6.414332649377085e-07 6.192848521170482 0.13229636467843553 ASVS(ph)GPNS(ph)PSETRR ddPTM_A459_Selumetinib_30min_R1 1 ASVSGPNSPSETRR 14 1 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 2 AS(0.003)VS(0.952)GPNS(0.944)PS(0.075)ET(0.025)RR 101.2 0.028432 11019000.0 1481.4 1677.9 1983.4 2589.1 1999.7 1628.5 1813.1 1583.0 916.25 1370.7 True False 1515.913737697384 1481.4506879654525 1714.0651740363453 2136.96228842627 1818.827488075709 1612.1187685596958 1676.3364072648149 1541.013697691323 1554.809329747724 1546.642696748644 0.9801318306316911 0.9578493410790752 1.1082489689697932 1.3816780649587632 1.1759842734842718 1.0423343232077427 1.083854991711281 0.9963605045501754 1.0052802324779004 1.0 10.594924230533111 -7.471611889178223 1.6948301087986435 0.9995413084512107 1.1195181546355168 0.15643828475143096 0.11092466421443666 0.8101006463055519 4.528904297869046 0.07950013998596521 0.04069415742133403 3.375888629486918e-08 7.471611889178223 0.11997684618430615 ASVS(ph)GPNS(ph)PSETRR ddPTM_A459_Selumetinib_30min_R2 2 ASVSGPNSPSETRR 14 1 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 2 AS(0.015)VS(0.955)GPNS(0.846)PS(0.105)ET(0.079)RR;AS(0.047)VS(0.953)GPNS(0.466)PS(0.458)ET(0.077)RR 99.796 0.031739 16527500.0 105525.0 84502.0 114775.0 119586.0 109419.0 78746.0 69709.4 83412.0 64735.0 92293.3 True False 99660.34295004485 90983.03168324498 107390.50145757117 103298.18050264342 95672.80700172872 89592.54671498411 72951.0252265555 83654.7151104001 77683.80884702598 89628.55262220814 1.1119262783381267 1.0151121380565642 1.1981728848197641 1.15251420981943 1.0674367063027073 0.9995982763732023 0.8139261774543006 0.933348945876787 0.8667305961580095 1.0 16.451670778846427 -6.876880071486239 2.5931793685167897 0.8982069830416947 1.1149237341366043 0.6987155828914542 0.06357287775206727 0.1515332791357838 2.0697529016514706 0.024692475391950273 0.021348294333052634 1.327761062495158e-07 6.876880071486239 0.21671675109490962 ASVS(ph)PMDEPVPDSES(ph)PIEK ddPTM_A459_Selumetinib_30min_R1 1 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 AS(0.162)VS(0.838)PMDEPVPDS(0.098)ES(0.902)PIEK 130.14 0.0011724 4084600.0 2820.5 2970.4 3271.5 3708.5 3254.3 2966.1 3079.9 3160.2 1741.1 2738.8 True False 2886.212162262367 2622.6241870985045 2827.2482690631764 3060.880092166707 2959.94913959333 2936.2637270033238 2847.5806633582833 3076.3812302237016 2954.5195350873264 3090.3516581711433 0.9339429558545499 0.8486491109075147 0.9148629611739169 0.9904633616933171 0.9578033398778362 0.9501390300484418 0.9214422752922136 0.9954793403816997 0.9560463862665385 1.0 11.593555299695643 -1.5228787452803583 0.1904649414981402 0.9958686705044332 0.5055731605357267 0.3929405438516108 0.03377008474142806 55.63421395659164 0.6513027486636555 0.07104602248679216 8.022300977942033 0.02999999999999857 1.5228787452803583 -0.4902955099687065 ASVS(ph)PMDEPVPDSESPIEK ddPTM_A459_Selumetinib_30min_R1 16 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AS(0.037)VS(0.963)PMDEPVPDSESPIEK;AS(0.015)VS(0.985)PMDEPVPDSESPIEK;AS(0.18)VS(0.82)PMDEPVPDSESPIEK;AS(0.023)VS(0.977)PMDEPVPDSESPIEK;AS(0.02)VS(0.98)PMDEPVPDSESPIEK;AS(0.024)VS(0.976)PMDEPVPDSESPIEK;ASVS(1)PMDEPVPDSESPIEK;AS(0.038)VS(0.959)PMDEPVPDS(0.001)ES(0.002)PIEK;AS(0.015)VS(0.985)PMDEPVPDSESPIEK;AS(0.005)VS(0.995)PMDEPVPDSESPIEK;AS(0.002)VS(0.998)PMDEPVPDSESPIEK;ASVS(1)PMDEPVPDSESPIEK;AS(0.178)VS(0.822)PMDEPVPDSESPIEK;AS(0.021)VS(0.979)PMDEPVPDSESPIEK;AS(0.249)VS(0.751)PMDEPVPDSESPIEK;AS(0.009)VS(0.991)PMDEPVPDSESPIEK 358.85 1.5040999999999982e-216 983531300.0 64876.92 73912.69000000002 80505.26999999999 83434.7 78998.91000000002 67953.73 70863.87 64687.02000000001 40055.85 58087.46 True False 66388.42600748892 65258.957893722625 69573.09651779415 68864.39590829209 71853.47253889036 67270.17717325015 65518.55123307096 62971.31009654623 67971.85188646684 65543.55131077481 1.0128902795136645 0.9956579493884488 1.0614788964960602 1.0506662292644395 1.0962706643434235 1.026343184462016 0.9996185730372571 0.9607552358273616 1.037048657375586 1.0 16.00016622331264 -10.948291673310871 7.0198002261607275 0.9999975140374368 1.0268523453512874 0.04729795527466096 0.03601077895633945 1.550656721153333e-06 1.2690313026176934e-07 0.03859093985267027 0.009358811342707557 1.1264406815676988e-11 10.948291673310871 0.02685483131385069 ASVS(ph)PMDEPVPDSESPIEK ddPTM_A459_Selumetinib_30min_R2 12 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 AS(0.021)VS(0.979)PMDEPVPDSESPIEK;AS(0.011)VS(0.989)PMDEPVPDSESPIEK;AS(0.018)VS(0.982)PMDEPVPDSESPIEK;AS(0.22)VS(0.766)PMDEPVPDS(0.006)ES(0.008)PIEK;AS(0.025)VS(0.975)PMDEPVPDSESPIEK;AS(0.028)VS(0.972)PMDEPVPDSESPIEK;AS(0.015)VS(0.985)PMDEPVPDSESPIEK;AS(0.371)VS(0.629)PMDEPVPDSESPIEK;AS(0.009)VS(0.991)PMDEPVPDSESPIEK;AS(0.013)VS(0.987)PMDEPVPDSESPIEK;AS(0.006)VS(0.994)PMDEPVPDSESPIEK;AS(0.019)VS(0.981)PMDEPVPDSESPIEK 276.38 5.1677e-60 544636700.0 2404631.0 2285185.0 2354298.0 2565299.0 2642086.0 2093975.0 1975981.0 2168605.0 1805244.0 2353697.0 True False 2270991.2355205775 2460451.3414721084 2202825.02984585 2215900.8508123974 2310163.5361314723 2382401.0490375254 2067868.0318320733 2174915.281518117 2166343.2427317523 2285739.651970776 0.9935476394096405 1.0764355158955639 0.9637252553879282 0.9694458635749863 1.0106853307373123 1.0422888919056934 0.9046822240009476 0.9515148760021267 0.9477646506521076 1.0 21.124229657828174 -7.256584574271004 24.998494843465302 0.9469500108062767 1.0085762474549387 0.36444242843139896 0.037599069096289094 452.61875705739084 2330646.3539220165 0.0148833380261877 0.011138585975301549 5.538796712097214e-08 7.256584574271004 0.06162623664866196 ASVS(ph)QTSPQSASSPR ddPTM_A459_Selumetinib_30min_R2 1 ASVSQTSPQSASSPR 15 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 ASVS(0.992)QT(0.001)S(0.002)PQS(0.003)AS(0.001)S(0.002)PR 83.292 0.023763 7202400.0 7027.7 5168.2 5942.7 8279.2 7324.7 5767.8 4558.5 6809.4 5719.2 4888.4 True False 6637.128568112104 5564.584321617788 5560.353151922534 7151.558677583382 6404.505702351175 6562.262095124641 4770.479282496391 6829.214226643146 6863.199807799648 4747.2591904114715 1.3980969443416522 1.1721677916506335 1.1712765047995173 1.506460547178069 1.3490954349589792 1.3823264818527536 1.0048912627589028 1.4385593776798227 1.4457183676977148 1.0 12.21287910470816 ASVSGPNS(ph)PSESR ddPTM_A459_Selumetinib_30min_R2 1 ASVSGPNSPSESR 13 0 A6PVI4;Q9UJV3-2;Q9UJV3 A6PVI4 MID2 Probable E3 ubiquitin-protein ligase MID2 1 ASVSGPNS(0.481)PS(0.481)ES(0.038)R 114.21 0.0048842 0.0 6271.3 6556.2 8622.6 7459.3 8732.3 5952.8 8043.4 5408.4 6930.0 7723.2 True False 5922.766252002989 7059.039458494354 8067.8313035770425 6443.330471989773 7635.270406247512 6772.744165861846 8417.434037694733 5424.137548591179 8316.193640378295 7500.211148716531 0.789679934946434 0.9411787639741753 1.0756805566677472 0.8590865435958271 1.0180073940390455 0.903007132941961 1.1222929422640535 0.7231979795021346 1.1087946026428066 1.0 12.872715496126373 -4.781616618310127 4.478389720478617 0.9686575463813822 0.7779162355051488 0.1848235173694328 0.11609772002367084 0.3093282729786947 13.358613746820627 0.026518544432430794 0.18311598819295835 1.653420742694955e-05 4.781616618310127 -0.19074131087623347 ASVSGPNS(ph)PSETR ddPTM_A459_Selumetinib_30min_R1 1 ASVSGPNSPSETR 13 0 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 ASVSGPNS(0.774)PS(0.225)ETR 233.28 2.1040999999999998e-13 35050000.0 3944.4 5013.5 3206.1 3460.7 3533.2 3289.0 4247.0 3725.9 1624.0 3250.8 True False 4036.2968455336545 4426.517089287085 2770.7292298466914 2856.3537103846083 3213.622683837123 3255.9156461730668 3926.6453707206842 3627.077028571131 2755.809387732937 3668.0718454734733 1.1003865288283772 1.2067694624764667 0.75536394775524 0.7787071329885338 0.8761067992173719 0.8876368248323648 1.0704930372523371 0.9888238784218659 0.7512964586922419 1.0 11.840806181526677 -5.250258245436913 24.92238007874908 0.8902518527848053 1.1535780237036108 0.505167081361527 0.10490908943131191 602.1336729095684 1342129.7601802363 0.028407007186682456 0.07365653972747564 5.620070383896428e-06 5.250258245436913 0.2633261709188055 ASVSGPNS(ph)PSETRR ddPTM_A459_Selumetinib_30min_R1 5 ASVSGPNSPSETRR 14 1 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 ASVSGPNS(0.999)PS(0.001)ETRR;ASVS(0.002)GPNS(0.478)PS(0.478)ET(0.042)RR;ASVSGPNS(0.697)PS(0.293)ET(0.01)RR;ASVS(0.036)GPNS(0.517)PS(0.145)ET(0.302)RR;ASVS(0.004)GPNS(0.378)PS(0.239)ET(0.378)RR 188.0 0.00016293 100057800.0 6994.74 7561.43 9016.1 8872.289999999999 7992.71 6679.45 7661.36 6133.360000000001 3768.22 5797.14 True False 7157.703832605233 6676.134260386562 7791.763141892257 7322.911105010044 7269.770791727566 6612.260797455362 7083.457447003676 5970.6833688389515 6394.394120100371 6541.259387925465 1.0942394129512225 1.0206190986264914 1.1911717117158054 1.1194956002704055 1.111371734493034 1.0108543944398474 1.0828889403283803 0.9127727574693427 0.9775478605700619 1.0 12.675352709039634 -7.302032840732346 1.3087041732167393 0.9639932860748883 1.1061129876011833 0.5181808418450493 0.05398931960665451 0.35781420234981903 1.1881751598162924 0.03512895118282667 0.019633166915674106 4.988467639494334e-08 7.302032840732346 0.14211970152629494 ASVSGPNS(ph)PSETRR ddPTM_A459_Selumetinib_30min_R2 4 ASVSGPNSPSETRR 14 1 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 ASVSGPNS(0.615)PS(0.018)ET(0.366)RR;ASVSGPNS(0.99)PS(0.01)ETRR;ASVSGPNS(0.997)PS(0.002)ETRR;ASVSGPNS(0.605)PS(0.019)ET(0.375)RR 129.89 0.0005214 266774000.0 219403.0 203416.0 214419.0 228688.0 221958.0 141183.0 162562.0 162613.0 150253.0 202571.0 True False 207209.4595997981 219017.35311446976 200623.51498175543 197540.29989119567 194073.6517103038 160629.67671832995 170121.45511049213 163086.17690796874 180307.79841959017 196722.24888733414 1.0533097337580264 1.1133329064365485 1.019831341480117 1.0041584061207538 0.9865363618400518 0.8165302990732128 0.8647799426485985 0.8290174488670609 0.916560274394053 1.0 17.585800607163698 -6.309889480793295 1.5606249394493839 0.8748103839165338 1.0667252980532118 0.6430969805604433 0.0562787167445358 0.21909868662211282 1.0641015789751351 0.02043947263216942 0.026720779732747044 4.899034740829573e-07 6.309889480793295 0.19191491413667805 ASVSGPNSPS(ph)ETR ddPTM_A459_Selumetinib_30min_R1 2 ASVSGPNSPSETR 13 0 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 ASVS(0.002)GPNS(0.085)PS(0.911)ET(0.002)R;ASVS(0.001)GPNS(0.23)PS(0.76)ET(0.009)R 144.4 0.00067113 39555000.0 3973.88 5822.8 3931.15 3964.5 4178.6 4202.6 5020.6 3978.8 2328.01 3446.75 True False 4066.4636721755596 5141.063869053721 3397.3214222612596 3272.1744978818692 3800.6463677917504 4160.325659655494 4641.892099891749 3873.269299036159 3950.462938876943 3889.1739366881056 1.045585447802941 1.3218909600715065 0.8735329089329207 0.8413546298390415 0.9772374364485887 1.069719618454065 1.1935419128733116 0.9959105357819273 1.0157588740402361 1.0 11.925248042958481 -5.263787975339213 24.97128586080424 0.9992475695867278 1.1837381974407386 0.31534783590040893 0.11063097481292336 246.31258779342483 2618932.8419922204 0.03093591178478135 0.06963390812105902 5.447685465638429e-06 5.263787975339213 0.18449062785401082 ASVSGPNSPS(ph)ETR ddPTM_A459_Selumetinib_30min_R2 1 ASVSGPNSPSETR 13 0 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 AS(0.003)VSGPNS(0.043)PS(0.931)ET(0.024)R 127.05 0.0019662 4108200.0 16573.0 13477.0 17219.0 18006.0 16638.0 12369.0 20183.0 15107.0 14862.0 14942.0 True False 15651.93900697552 14510.642564614935 16111.14828662968 15553.55173791748 14547.785694392784 14072.717475397338 21121.549491855792 15150.958868901518 17834.8152789758 14510.58563602164 1.0786566028128142 1.000003923245741 1.1103031049715002 1.0718762238862876 1.0025636496902508 0.9698242254580461 1.4555959367637679 1.0441314533363968 1.2290899710279068 1.0 13.824818126185969 ASVSGPNSPS(ph)ETRR ddPTM_A459_Selumetinib_30min_R1 1 ASVSGPNSPSETRR 14 1 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 ASVSGPNS(0.282)PS(0.64)ET(0.079)RR 169.15 0.00032878 63931000.0 2203.2 2306.6 3136.6 3023.9 3021.0 2398.9 2663.8 2122.0 1198.0 1802.1 True False 2254.530273319073 2036.5421996907517 2710.6669481105178 2495.832630633115 2747.751083400868 2374.769244026928 2462.867421362317 2065.717666772578 2032.9185015419075 2033.41708894049 1.1087397099105691 1.0015368764073336 1.3330599820634477 1.2274081122892335 1.3512973301668185 1.1678711942291677 1.2111963820691563 1.0158848757629544 0.9997548031826357 1.0 10.989690451851132 -7.774596155947464 7.205559020011922 1.004555524180489 1.2034304465152956 0.46862183485924047 0.09509999027417851 0.14292364466064827 36.282742156241 0.05396682909910906 0.02726194589337046 1.6803658393373936e-08 7.774596155947464 0.19887492233480653 ASVSGPNSPSES(ph)RR ddPTM_A459_Selumetinib_30min_R1 2 ASVSGPNSPSESRR 14 1 A6PVI4;Q9UJV3-2;Q9UJV3 A6PVI4 MID2 Probable E3 ubiquitin-protein ligase MID2 1 ASVSGPNSPS(0.024)ES(0.976)RR;ASVSGPNSPS(0.007)ES(0.993)RR 159.18 0.00053908 3029800.0 1286.52 1414.0900000000001 1712.94 1922.6 1761.83 1314.13 1420.0900000000001 1368.26 998.9 1063.37 True False 1316.493412867853 1248.527685407394 1480.3321565059086 1586.8540016717561 1602.4727875763506 1300.9110453345731 1312.9714679789813 1331.9693000651494 1695.0603432305602 1199.863897600937 1.097202287276174 1.0405577565120159 1.2337500607075125 1.3225283341257161 1.335545465431878 1.0842155080552673 1.0942670002857797 1.1101003228185713 1.4127105137672211 1.0 10.228655052669096 -10.290977484934896 6.57521878368934 0.9999999987594527 1.1886351822022958 0.18305090880121222 0.12166287784221991 2.8765972575842616e-09 5.627759161580784e-10 0.12416397028347755 0.030114185915327735 5.11708363274263e-11 10.290977484934896 0.18863518344284314 ASVSGPNSPSET(ph)R ddPTM_A459_Selumetinib_30min_R2 1 ASVSGPNSPSETR 13 0 C9J453;A0A087X255;O15344-2;O15344;A0A087X0X0 C9J453 MID1 E3 ubiquitin-protein ligase Midline-1 1 ASVSGPNS(0.264)PS(0.116)ET(0.619)R 137.73 0.0023987 40219000.0 38420.0 30202.0 33668.0 36648.0 32800.0 27613.0 35770.0 32812.0 26071.0 25160.0 True False 36284.77020744579 32518.39628526381 31501.837534946724 31656.47917867376 28679.37076427958 31416.440104143152 37433.37587691036 32907.477487681004 31285.92848460353 24433.565426469333 1.4850378802324866 1.3308903435777748 1.2892853329060279 1.2956143987229842 1.1737693727338987 1.2857902461549529 1.5320472155225489 1.3468143888665436 1.2804487572129324 1.0 14.576576781335785 -8.730658719294718 3.2799307583946877 1.0000392528989055 1.3368070947190103 0.5278547162703563 0.09664949815159121 1.2260047343930565 18.30737899797144 0.09964388954270212 0.02634394448405486 1.8592649433703531e-09 8.730658719294718 0.3367678418201048 ASVSPMDEPVPDS(ph)ESPIEK ddPTM_A459_Selumetinib_30min_R1 5 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ASVSPMDEPVPDS(0.649)ES(0.351)PIEK;ASVSPMDEPVPDS(0.985)ES(0.015)PIEK;ASVSPMDEPVPDS(0.718)ES(0.282)PIEK;ASVS(0.001)PMDEPVPDS(0.819)ES(0.18)PIEK;ASVSPMDEPVPDS(0.839)ES(0.161)PIEK 242.1 2.1665e-29 65798000.0 14846.3 16322.499999999998 16930.0 17952.699999999997 15438.0 15117.2 14512.899999999998 14192.599999999999 8781.490000000002 12443.01 True False 15192.189904128969 14411.454111875619 14630.99898983328 14817.597958916333 14041.635625800276 14965.13469331938 13418.180268597174 13816.16614393802 14901.547155346612 14040.19153868121 1.0820500462742237 1.0264428424762986 1.0420797287219605 1.0553700722738248 1.0001028538047425 1.0658782433337834 0.9556978073717602 0.9840439929807231 1.061349278198402 1.0 13.777274996817324 -6.515934708449798 1.0631547579045912 1.004064815682672 1.051163731415356 0.23898319969086246 0.03393842863473393 0.7636361294504259 1.8423536463627284 0.01655345860413857 0.01925433454578518 3.048353242626048e-07 6.515934708449798 0.04709891573268399 ASVSPMDEPVPDS(ph)ESPIEK ddPTM_A459_Selumetinib_30min_R2 7 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ASVSPMDEPVPDS(0.651)ES(0.349)PIEK;ASVSPMDEPVPDS(0.993)ES(0.007)PIEK;ASVSPMDEPVPDS(0.959)ES(0.041)PIEK;ASVSPMDEPVPDS(0.999)ES(0.001)PIEK;ASVSPMDEPVPDS(0.886)ES(0.114)PIEK;ASVSPMDEPVPDS(0.965)ES(0.035)PIEK;ASVSPMDEPVPDS(0.914)ES(0.086)PIEK 202.96 1.1484e-15 84303900.0 525523.0 468544.0 488067.0 519888.0 508405.0 369476.0 418572.0 386455.0 346303.0 497019.0 True False 496316.5354952508 504479.81819358433 456665.30058717 449078.35754317674 444534.61870163295 420367.965230811 438036.4273846837 387579.520068931 415573.27651427407 482668.770059553 1.0282756338969556 1.0451884387119976 0.9461256433284991 0.9304069071793649 0.9209931246365599 0.870924309395333 0.907530079749385 0.8029927439082301 0.8609906053441152 1.0 18.880673958070837 -5.518082116777579 0.9004783386345729 0.8781611989259115 1.0644994497819376 0.5467384925213852 0.04903057110269535 0.6301618723387001 0.8032626306300482 0.01902554710854833 0.09326561009903162 3.0333175876457065e-06 5.518082116777579 0.18633825085602607 ASVSPMDEPVPDSES(ph)PIEK ddPTM_A459_Selumetinib_30min_R1 6 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ASVSPMDEPVPDS(0.429)ES(0.571)PIEK;ASVSPMDEPVPDS(0.124)ES(0.876)PIEK;ASVSPMDEPVPDSES(1)PIEK;ASVSPMDEPVPDS(0.001)ES(0.999)PIEK;ASVSPMDEPVPDS(0.015)ES(0.985)PIEK;ASVSPMDEPVPDS(0.008)ES(0.992)PIEK 314.39 3.674699999999998e-117 752168000.0 58222.2 65282.2 73478.3 72088.3 64002.5 59278.9 61880.7 57358.3 34666.200000000004 49405.1 True False 59578.66397931995 57638.92967512859 63500.350447411 59499.43166998555 58213.48517555913 58682.60808693481 57212.98897856263 55836.97155798375 58826.00948092827 55746.725831426564 1.068738353521978 1.0339428695673336 1.1390866369341717 1.0673170627079849 1.0442494031235456 1.052664658089268 1.0263022289698218 1.0016188525014023 1.0552370314772064 1.0 15.766599453363066 -6.780094277265743 1.3006482218701096 1.0207726551386338 1.0774477981367117 0.41676831125718616 0.028882886453027765 0.45125341922889634 1.600762823609587 0.014311170717134199 0.012692998381494137 1.659226681044593e-07 6.780094277265743 0.056675142998077854 ASVSPMDEPVPDSES(ph)PIEK ddPTM_A459_Selumetinib_30min_R2 10 ASVSPMDEPVPDSESPIEK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ASVSPMDEPVPDS(0.084)ES(0.916)PIEK;ASVSPMDEPVPDS(0.021)ES(0.979)PIEK;ASVSPMDEPVPDS(0.155)ES(0.845)PIEK;ASVSPMDEPVPDS(0.112)ES(0.888)PIEK;ASVSPMDEPVPDS(0.072)ES(0.928)PIEK;ASVSPMDEPVPDS(0.01)ES(0.99)PIEK;ASVSPMDEPVPDS(0.209)ES(0.791)PIEK;ASVSPMDEPVPDS(0.014)ES(0.986)PIEK;ASVSPMDEPVPDS(0.085)ES(0.915)PIEK;ASVSPMDEPVPDS(0.32)ES(0.68)PIEK 245.1 1.6358999999999998e-30 586471600.0 965516.0 862892.0 953308.0 998420.0 964722.0 742788.0 781840.0 803535.0 634786.0 864685.0 True False 911856.4859867853 929073.041764909 891973.201163269 862433.4736294309 843524.9976358948 845100.3046418804 818197.1091865684 805873.1538176195 761760.9374027672 839719.2973285608 1.085906312844921 1.106409063981992 1.0622278230367528 1.0270497252750195 1.004532110098507 1.006408102481911 0.9743697826041845 0.9596935027947819 0.9071614048006206 1.0 19.67954761657674 -6.0945968127448475 0.6479543024911744 0.9528712754134462 1.1133738350155844 0.8194791182486061 0.024214210375880903 0.38304418975640386 0.3207274161372557 0.015333456012988106 0.03631092621570566 8.042724404901045e-07 6.0945968127448475 0.16050255960213822 ASVSQT(ph)SPQSASSPR ddPTM_A459_Selumetinib_30min_R2 2 ASVSQTSPQSASSPR 15 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 ASVS(0.003)QT(0.428)S(0.428)PQS(0.128)AS(0.011)SPR;ASVSQT(0.719)S(0.242)PQS(0.021)AS(0.018)SPR 226.06 2.8159e-13 28088800.0 44779.0 32774.0 46140.0 41874.0 48829.0 29657.0 32359.0 36134.0 32086.1 37517.0 True False 42290.36244453972 35287.6604149803 43171.40263343359 36170.68896332091 42694.66448320142 33741.98255055856 33863.75761814207 36239.14395769426 38504.21656053997 36433.786729127576 1.160745731948033 0.9685422126810941 1.1849276868857421 0.9927787422218088 1.1718426305950922 0.9261179136118451 0.9294602800940576 0.994657629938924 1.0568271930339088 1.0 15.152989328278828 -6.771905223271142 24.999932707046252 0.9778316870987812 1.0879310987741393 0.36149819753134926 0.07555667312748848 239.17136319978465 571308.8890133079 0.02518901027679939 0.022448130206632267 1.6908098793312883e-07 6.771905223271142 0.11009941167535808 ASVSQTS(ph)PQSASSPR ddPTM_A459_Selumetinib_30min_R1 2 ASVSQTSPQSASSPR 15 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 ASVS(0.054)QT(0.206)S(0.519)PQS(0.152)AS(0.054)S(0.016)PR;ASVSQT(0.017)S(0.683)PQS(0.201)AS(0.095)S(0.004)PR 227.41 1.0436e-13 47821000.0 4584.1 4992.4 5499.6 6025.7 5524.3 4134.2 4823.3 4387.1 2242.4700000000003 4089.2 True False 4690.9006108941385 4407.887487096205 4752.784527140409 4973.424611397847 5024.628040394381 4092.6137015532613 4459.47459773889 4270.739856690847 3805.307806471355 4614.088652181042 1.016647265473928 0.9553105324520874 1.0300592132953075 1.0778779920162458 1.0889751843019488 0.8869820261513001 0.9664908791102081 0.9255868663624621 0.8247149314464552 1.0 12.171830007979313 -6.769386069296998 24.999573244910486 0.9189626068886534 1.0316587969696527 0.5132039603468956 0.05500329460633872 157.8208126795014 496487.0069064174 0.019961981370953424 0.01791707570982704 1.7006460343412093e-07 6.769386069296998 0.11269619008099929 ASVSQTS(ph)PQSASSPR ddPTM_A459_Selumetinib_30min_R2 1 ASVSQTSPQSASSPR 15 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 AS(0.005)VS(0.004)QT(0.26)S(0.354)PQS(0.106)AS(0.26)S(0.01)PR 178.99 1.9867e-05 20121000.0 11912.0 9378.2 12433.0 14041.0 11917.0 7658.9 9246.7 9018.3 10408.0 11303.0 True False 11249.978727514177 10097.477784334178 11633.074316026868 12128.591577923984 10419.879920668282 8713.843954428057 9676.689871988456 9044.54175994006 12489.8908238178 10976.65302127913 1.024900641908347 0.9199049805764472 1.05980158919802 1.1049444265398323 0.9492766055799069 0.7938525466310693 0.8815701701811481 0.823979927433844 1.1378596735822055 1.0 13.422150597307697 -6.512259560203018 24.449740384986875 0.9089147915662968 1.0226614188565213 0.17160531169111903 0.10031302966437011 604.3905714237421 1391560.413202997 0.03215646791161468 0.034247478884644605 3.074258905673902e-07 6.512259560203018 0.11374662729022444 ASVSQTSPQSAS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 ASVSQTSPQSASSPR 15 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 ASVS(0.003)QT(0.207)S(0.207)PQS(0.07)AS(0.513)S(0.001)PR 210.08 1.262e-06 5967600.0 16501.0 11832.0 17925.0 17491.0 18130.0 12018.0 12026.0 14950.0 15758.0 16145.0 True False 15583.940478736688 12739.476354123612 16771.72501526435 15108.695626342023 15852.347315743553 13673.370411458085 12585.232829066927 14993.502024894271 18910.04031530753 15678.851900252283 0.9939465324298351 0.8125260979038028 1.0697036442441608 0.96363533009065 1.0110655688691388 0.8720900291964664 0.802688418076353 0.9562882614289517 1.206085779469813 1.0 13.936532300070477 -8.117616377640868 7.170191791638944 1.100862833326717 0.9310893112283003 0.3460151626685083 0.09271056786360403 0.2795931350517605 15.30901288904748 0.06329257218160253 0.02365197194044014 7.627524694357543e-09 8.117616377640868 -0.16977352209841667 ASVVDPSTESSPAPQEGSEQPAS(ph)PASPLSSR ddPTM_A459_Selumetinib_30min_R2 1 ASVVDPSTESSPAPQEGSEQPASPASPLSSR 31 0 Q66K14;Q66K14-2 Q66K14 TBC1D9B TBC1 domain family member 9B 1 ASVVDPSTESSPAPQEGS(0.001)EQPAS(0.343)PAS(0.335)PLS(0.072)S(0.249)R 95.245 3.6935e-08 5872400.0 33983.0 29127.0 41792.0 43665.0 43411.0 31262.0 35836.0 37513.0 37183.0 33345.0 True False 32094.360904727506 31360.947241933594 39103.14821968917 37717.7516736736 37957.322080736005 35568.05673181919 37502.44500768688 37622.156619388545 44620.638979824835 32382.243209285345 0.9911098714595754 0.9684612347343836 1.207549086916766 1.1647664872969128 1.172164690241473 1.0983814957458025 1.1581175758983047 1.1618144047723258 1.377935391672626 1.0 14.98291530820464 -5.256743378251456 24.964808767309187 1.1706225747807513 0.9797855303954881 0.4157563979961819 0.08899445143535822 346.31394035668194 1841053.9026823035 0.021982246406761975 0.054341296271216595 5.536771767717244e-06 5.256743378251456 -0.19083704438526317 ASVVDPSTESSPAPQEGSEQPASPAS(ph)PLSSR ddPTM_A459_Selumetinib_30min_R2 1 ASVVDPSTESSPAPQEGSEQPASPASPLSSR 31 0 Q66K14;Q66K14-2 Q66K14 TBC1D9B TBC1 domain family member 9B 1 ASVVDPSTESSPAPQEGS(0.021)EQPAS(0.233)PAS(0.544)PLS(0.071)S(0.131)R 96.945 3.0163000000000003e-08 6666400.0 33423.0 27874.0 43234.0 39027.0 44655.0 31312.0 34308.0 35897.0 33766.0 33992.0 True False 31565.48346286991 30011.846170963632 40452.371509620054 33711.455274669854 39045.03967923487 35624.943777964356 35903.389980012325 36001.45432693175 40520.14350086776 33010.5626381775 0.9562237338652229 0.9091588804443527 1.2254372018135773 1.0212323747454626 1.1828044286066894 1.0791983211083855 1.0876333849120525 1.0906040809281818 1.2274902413812616 1.0 15.01064010788242 -5.243184163131878 24.954094398282464 1.1144525975186848 0.932691269915404 0.48877249107250753 0.07429328287958188 617.4757149751888 844059.5064046262 0.017407808969813695 0.04585324857171046 5.712363517975062e-06 5.243184163131878 -0.1817613276032808 ASYDVSDSGQLEHVQPWS(ph)V ddPTM_A459_Selumetinib_30min_R1 1 ASYDVSDSGQLEHVQPWSV 19 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 ASYDVSDSGQLEHVQPWS(1)V 139.49 0.00013175 5680000.0 1073.2 1605.6 1455.8 1207.4 1621.2 1257.1 1366.7 1059.3 619.24 1102.2 True False 1098.2034719163162 1417.615605576811 1258.1103561369928 996.5502557050241 1474.5627462461068 1244.4547153554754 1263.608718663518 1031.2039229086658 1050.8050524998423 1243.6781063371666 0.8830287084096891 1.1398573299259231 1.0116044897198773 0.8012927546340958 1.1856466224921598 1.00062444535636 1.0160255392651802 0.8291566102628665 0.8449172234724251 1.0 10.280397414436012 -7.749818448116919 24.855168867748375 0.8777776926186213 1.009740994795123 0.17470049040978686 0.11219978900038555 295.4514324002582 631922.8594397357 0.052179066256614136 0.029798862224816335 1.779022954984305e-08 7.749818448116919 0.13196330217650176 ASYDVSDSGQLEHVQPWS(ph)V ddPTM_A459_Selumetinib_30min_R2 1 ASYDVSDSGQLEHVQPWSV 19 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 ASYDVSDSGQLEHVQPWS(1)V 154.52 6.7105e-06 4594800.0 34300.0 32367.0 35835.0 39865.0 52311.0 35521.0 33049.0 31548.0 31657.0 32042.0 True False 32393.743313779043 34849.444823691585 33529.415114197946 34435.31822903923 45739.22451372646 40413.695322466556 34585.84398535114 31639.79945694745 37989.28457048421 31116.864204885955 1.0410349545662958 1.119953623675857 1.0775319419536231 1.1066448727707021 1.4699175409373195 1.298771465413948 1.111482306109768 1.0168055254095747 1.2208583847121444 1.0 14.925409059924808 -3.8524115750554317 15.228709784680909 1.1552808089700248 1.1361510827299015 0.0 0.13849280434578862 0.0 0.0 0.03373941842328828 0.0 0.00014047156629433814 3.8524115750554317 -0.019129726240123324 ASYHFSPEELDENTS(ph)PLLGDAR ddPTM_A459_Selumetinib_30min_R2 1 ASYHFSPEELDENTSPLLGDAR 22 0 E5RFM9;R4GMT7;O75410-7;O75410-9;O75410;O75410-2;E5RJU4;H0YAY0;E7EVI4;E7ET87;O75410-3 E5RFM9 TACC1 Transforming acidic coiled-coil-containing protein 1 1 ASYHFSPEELDENT(0.397)S(0.603)PLLGDAR 86.99700000000001 0.00036897 3432800.0 16195.0 11699.0 15591.0 18810.0 16803.0 14099.0 13785.0 15140.0 13083.0 19906.0 True False 15294.946733721634 12596.275681786015 14587.8920341973 16248.045550940116 14692.056919274073 16041.009272020929 14426.029814459296 15184.054893438075 15699.965569562662 19331.26205800074 0.7912026999495063 0.6516013100434238 0.7546269866099987 0.8405061967599495 0.7600154027808748 0.8297962763058165 0.7462539057810099 0.7854663005384982 0.8121541947161608 1.0 14.238648207754707 -14.522878745004078 0.19144329594715243 1.9870331051095629 0.7326613827740294 0.6792305644484429 0.04787466654013305 81.93245318827597 0.8005791292313297 30.80836579416279 0.13110547062240957 3.000000001908331e-15 14.522878745004078 -1.2543717223355335 AT(ph)GANAT(ph)PLAAAAS(ph)T(ph)ATVPRR ddPTM_A459_Selumetinib_30min_R1 1 ATGANATPLAAAASTATVPRR 21 1 F8WEG7 F8WEG7 SF1 4 AT(1)GANAT(1)PLAAAAS(0.997)T(0.997)AT(0.007)VPRR 51.029 0.025967 6483100.0 297.79 356.93 449.62 355.61 390.1 312.26 423.62 332.88 131.12 232.7 True False 304.72792760152805 315.14046966774487 388.5640735858736 293.50938912644 354.8155238777488 309.1189479093955 391.66600234158153 324.05094105337184 222.5010633741026 262.5693116899461 1.1605618556115376 1.200218211486486 1.4798533426659848 1.1178358477514285 1.3513213771788046 1.177285136331611 1.4916670947596447 1.2341539038500662 0.8473993474029519 1.0 8.036554498008854 -8.194004471572415 5.753152000747273 0.9252599640135286 1.2839224657860975 0.5551404868626122 0.1265920218186883 0.14016861480543727 8.77078123862504 0.08608928371583387 0.031016202694837097 6.397282486941084e-09 8.194004471572415 0.35866250177256886 AT(ph)NESEDEIPQLVPIGK ddPTM_A459_Selumetinib_30min_R1 1 ATNESEDEIPQLVPIGK 17 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AT(0.609)NES(0.391)EDEIPQLVPIGK 107.39 0.0045635 0.0 838.25 844.33 885.65 851.84 927.25 694.16 915.53 852.69 429.02 620.37 True False 857.7795940494336 745.4754510816323 765.3835945272203 703.0821350172006 843.3804012192843 687.1773806468517 846.4708350025687 830.07389127253 728.0156056189556 700.0005324155219 1.2253984880403688 1.0649641201117206 1.0934043034025678 1.004402286082619 1.2048282282143348 0.9816812256921852 1.2092431302610807 1.1858189427487411 1.0400215027076636 1.0 9.45121220913653 -4.753316436213931 24.830310346014617 1.0947646657786128 1.2253987503382702 0.19854046706772377 0.08205516240523444 475.14923550279303 1452315.9632017142 0.019599181729817006 0.21168359535093353 1.764751516568573e-05 4.753316436213931 0.13063408455965742 AT(ph)NESEDEIPQLVPIGK ddPTM_A459_Selumetinib_30min_R2 2 ATNESEDEIPQLVPIGK 17 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AT(0.577)NES(0.423)EDEIPQLVPIGK;AT(0.67)NES(0.33)EDEIPQLVPIGK 103.26 0.006249 112040000.0 12226.1 13033.2 14276.5 17705.6 16486.3 9758.2 11944.8 10447.3 8815.3 15100.2 True False 11546.622306956097 14032.804531656844 13357.965533077913 15294.066736136374 14415.143604607989 11102.303473880036 12500.256868172166 10477.699913356384 10578.606320061584 14664.217990968687 0.7874011634351973 0.956941893546542 0.9109224604615629 1.0429514035835796 0.9830148197118934 0.7571016388816408 0.8524325590270652 0.7145079212413051 0.7213890523570144 1.0 13.84001251708598 -6.762436899735957 24.99985692538507 0.7939521141265106 0.941917284089139 0.29000678251460577 0.09786163918259158 30.500533043757056 764391.9279734418 0.03298979708336039 0.030770371793266544 1.7280770410231e-07 6.762436899735957 0.14796516996262843 AT(ph)PEIPQVKPGSSEGEAEAPEEEEEK ddPTM_A459_Selumetinib_30min_R2 1 ATPEIPQVKPGSSEGEAEAPEEEEEK 26 1 Q8NEE8 Q8NEE8 TTC16 Tetratricopeptide repeat protein 16 1 AT(0.992)PEIPQVKPGS(0.004)S(0.004)EGEAEAPEEEEEK 41.208 0.032547 63593000.0 11355.0 19163.0 73598.0 129720.0 134410.0 106240.0 42504.0 120640.0 168940.0 79586.0 True False 10723.934557666507 20632.740481243312 68862.78480744363 112051.91222051822 117524.21415935416 120873.59564930153 44480.52022007819 120991.04242697275 202732.72057799582 77288.14539073873 0.13875264445084656 0.26695866975371474 0.8909876729387184 1.4497942945069704 1.520598192196197 1.5639344822962402 0.5755154298916351 1.5654540785690898 2.623076534610298 1.0 16.237959527237216 -5.446362487786878 2.011232372853947 1.4706617416419299 0.13531707235616686 0.5205695960360035 0.48775381082367397 0.2899096228158664 2.240988342809451 0.14597255378129878 0.42163834387320853 3.5779767339793514e-06 5.446362487786878 -1.335344669285763 AT(ph)PPPS(ph)PLLSELLK ddPTM_A459_Selumetinib_30min_R2 1 ATPPPSPLLSELLK 14 0 H7C128;H7C179;H7C127;Q9H0E9-3;Q9H0E9-4;Q9H0E9-2 H7C128 BRD8 Bromodomain-containing protein 8 2 AT(1)PPPS(1)PLLSELLK 129.93 0.013189 0.0 6746.1 7769.6 7597.0 5762.3 4986.8 6136.2 6906.5 5778.9 3747.4 7528.5 True False 6371.178768777984 8365.50333679841 7108.217290988193 4977.4647994780535 4360.313601442357 6981.405851122408 7227.66593497012 5795.7156422516055 4496.984711104418 7311.132643607885 0.8714352589879898 1.1442144117180475 0.9722457022035975 0.6808062501546659 0.5963937209174524 0.9549007235187073 0.9885836145086576 0.7927247288173321 0.6150872826847325 1.0 12.835879211049798 -5.607201978485475 7.031063849339235 0.8013533733899036 1.020042324428837 0.25503971478307996 0.15066849466653343 0.2841749472762874 19.665602486732425 0.04258778726068319 0.07423397438145624 2.4705748809848817e-06 5.607201978485475 0.21868895103893338 AT(ph)PPPSPLLSELLK ddPTM_A459_Selumetinib_30min_R1 1 ATPPPSPLLSELLK 14 0 H7C128;H7C179;H7C127;Q9H0E9-3;Q9H0E9-4;Q9H0E9-2 H7C128 BRD8 Bromodomain-containing protein 8 1 AT(1)PPPSPLLSELLK 115.12 0.006651300000000001 4603900.0 276.23 279.89 212.19 342.9 329.96 231.07 321.23 218.39 266.88 249.79 True False 282.6656215499852 247.12034868266906 183.37576347623894 283.0189520301911 300.11517625916946 228.74564559477352 296.9993624762433 212.5975877693039 452.87586785601377 281.8529796606432 1.0028832119863356 0.8767703963257975 0.6506078583842795 1.0041368105135937 1.0647933423322837 0.8115778867059983 1.0537385939074926 0.7542854009394394 1.606780486767554 1.0 8.138799009050588 -8.247341117288641 24.99945580600001 1.3033902968664242 0.9039335105251444 0.4250381994407385 0.18656806299237938 614.105752933617 1088955.5040780914 0.11981589142724174 0.04480093244325307 5.65794710112342e-09 8.247341117288641 -0.3994567863412798 AT(ph)PPPSPLLSELLK ddPTM_A459_Selumetinib_30min_R2 3 ATPPPSPLLSELLK 14 0 H7C128;H7C179;H7C127;Q9H0E9-3;Q9H0E9-4;Q9H0E9-2 H7C128 BRD8 Bromodomain-containing protein 8 1 AT(1)PPPSPLLSELLK;AT(1)PPPSPLLSELLK;AT(1)PPPSPLLSELLK 160.46 0.0006793999999999999 98310900.0 100400.56 101333.11 100983.26 121693.9 115767.1 86537.99 107516.39 109656.23 93921.66 87787.33 True False 94820.69881048611 109105.03369969652 94486.1069938601 105118.98088631338 101223.40192699479 98457.81260884138 112516.11517468517 109975.31147473399 112708.6163904434 85252.68168402425 1.1122312745764904 1.2797841844327815 1.1083065673412842 1.233028437462184 1.1873339339888862 1.1548940240233132 1.3197956117287732 1.2899924002665428 1.3220536194765145 1.0 16.379457595403487 -7.243954664425914 24.90992484666035 1.2571264480208673 1.183417653442524 0.043457371868230066 0.09930911136043802 1697.1484925689151 2417876.6972376313 0.03534611975247189 0.027312890311915923 5.702237942753683e-08 7.243954664425914 -0.07370879457834323 AT(ph)PPPSPLLSELLKK ddPTM_A459_Selumetinib_30min_R1 1 ATPPPSPLLSELLKK 15 1 H7C128;H7C179;H7C127;Q9H0E9-3;Q9H0E9-4;Q9H0E9-2 H7C128 BRD8 Bromodomain-containing protein 8 1 AT(1)PPPSPLLSELLKK 112.91 0.0036103 15766000.0 4587.2 2439.2 5202.3 5238.5 4400.7 3418.1 3342.0 3717.3 2185.5 2939.2 True False 4694.072834862585 2153.617330046685 4495.8562341884035 4323.694313823727 4002.6574620066904 3383.717017386488 3089.910249340363 3618.7051285078714 3708.633877395525 3316.4749502324444 1.4153801567334583 0.6493693944215507 1.3556129027518506 1.3037017853913502 1.2069011592341903 1.020275162081152 0.9316850860350379 1.091129944537722 1.1182457075804522 1.0 11.695434913714855 -6.767306455583272 24.630143539879565 1.0316763943336746 1.1723100183834259 0.12529610051989504 0.201685623901386 296.8031679046687 1245977.655059669 0.07016917161570549 0.06354837115214915 1.708809085416707e-07 6.767306455583272 0.14063362404975122 AT(ph)PSENLVPSSAR ddPTM_A459_Selumetinib_30min_R1 2 ATPSENLVPSSAR 13 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 AT(0.993)PS(0.007)ENLVPSSAR;AT(0.949)PS(0.051)ENLVPSSAR 167.03 0.00074065 45442000.0 1681.88 2246.87 1937.52 1582.38 1835.9099999999999 1858.0500000000002 2096.8 1993.52 1006.25 1703.79 True False 1721.0645316312107 1983.8054158584769 1674.4154260355463 1306.0470379513972 1669.8522646562358 1839.3597039744188 1938.6366878566355 1940.645373734432 1707.5327564077995 1922.4880428199972 0.895227691042838 1.0318948007336037 0.8709627257704208 0.6793524895143822 0.8685891550237248 0.9567600229525268 1.0083998676074732 1.0094447042114243 0.8881890125584911 1.0 10.908758909835957 -6.811498626640422 4.765299204219864 0.977318178502208 0.8675644265401002 0.2673638610040827 0.0858776206164149 0.31391964635775177 15.137388986105293 0.03387811608813039 0.030456500383430417 1.5434813042326945e-07 6.811498626640422 -0.10975375196210779 AT(ph)PSENLVPSSAR ddPTM_A459_Selumetinib_30min_R2 2 ATPSENLVPSSAR 13 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 AT(0.984)PS(0.016)ENLVPSSAR;AT(0.987)PS(0.012)ENLVPSSAR 115.1 0.009517200000000002 60745000.0 74646.0 63395.0 68872.0 80918.0 80265.0 62677.0 76658.0 74193.0 60477.0 83720.0 True False 70497.47415161366 68257.19265294675 64440.85050216382 69896.82880866398 70181.3931217958 71310.18782484274 80222.74889494525 74408.88934668762 72574.08986856542 81302.78606931689 0.8670978887674172 0.8395430950515304 0.792603225764281 0.8597101303400789 0.8632101864499545 0.8770940243553931 0.9867158651432827 0.9152071281204104 0.8926396422219827 1.0 16.311017170712205 -6.977404175156768 2.7467600703059807 0.9415226917876509 0.8413288846127199 0.6491136826683723 0.035763221144944124 0.18362608022545943 2.8110812360869195 0.014559197167308142 0.011875032857198549 1.0534060901241165e-07 6.977404175156768 -0.10019380717493098 AT(ph)PTKAPAPVVLGS(ph)PVVLGPPVGQAR ddPTM_A459_Selumetinib_30min_R1 1 ATPTKAPAPVVLGSPVVLGPPVGQAR 26 1 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 2 AT(0.864)PT(0.139)KAPAPVVLGS(0.997)PVVLGPPVGQAR 87.281 0.0023641 0.0 602.9 934.12 700.5 806.78 866.14 737.42 916.82 865.77 550.13 772.35 True False 616.9463969608157 824.752796139394 605.3759475710698 665.8910181362426 787.7977899294369 730.0022243237888 847.6635292639829 842.8069671827021 933.5304300945327 871.4886458260848 0.7079224725595956 0.9463723940518011 0.6946458229495731 0.7640845595929066 0.9039679331480936 0.8376497247784784 0.9726615869567433 0.9670888671002761 1.0711905824196233 1.0 9.76733805812212 -7.212520004629602 0.9923309697961518 1.0309625980687505 0.7893782970733282 0.637885968013331 0.07391377877821823 0.3576326281661561 0.6924333885989974 0.05190494282484608 0.030862111160582465 6.130275540024129e-08 7.212520004629602 -0.24158430099542227 AT(ph)PTKAPAPVVLGSPVVLGPPVGQAR ddPTM_A459_Selumetinib_30min_R2 1 ATPTKAPAPVVLGSPVVLGPPVGQAR 26 1 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 AT(0.84)PT(0.16)KAPAPVVLGSPVVLGPPVGQAR 83.992 0.00014333 10364000.0 17124.0 12997.0 15789.0 15420.0 16043.0 14189.0 14121.0 12494.0 15566.0 15343.0 True False 16172.316632803275 13993.828108058198 14773.152929763399 13319.769399016302 14027.534913760279 16143.405955082286 14777.654480230669 12530.35547150696 18679.634950379306 14900.007724098517 1.0853898153788866 0.9391826076321618 0.9914862598272381 0.8939437915507643 0.9414448081844182 1.083449502443731 0.9917883771516467 0.8409630185117957 1.2536661252978958 1.0 13.863025458123849 -6.732639650272578 24.991597330281135 1.0213971120416463 0.9654974714989832 0.0754587686379583 0.1063630148271048 670.3486139487416 581708.5318468506 0.034084046435584076 0.03407841405624977 1.8508036603110304e-07 6.732639650272578 -0.055899640542663054 AT(ph)SDEEDSVLNIAR ddPTM_A459_Selumetinib_30min_R1 2 ATSDEEDSVLNIAR 14 0 Q5JPF3-3;Q5JPF3 Q5JPF3-3 ANKRD36C Ankyrin repeat domain-containing protein 36C 1 AT(0.853)S(0.147)DEEDSVLNIAR;AT(0.968)S(0.032)DEEDSVLNIAR 201.08 0.00014677 6055000.0 1728.61 1875.29 2087.6800000000003 2302.33 1978.55 2082.76 1955.0500000000002 1651.72 1021.44 1644.39 True False 1768.8832497104597 1655.730175001331 1804.1845228053846 1900.271285586671 1799.5905018413741 2061.8093253947736 1807.5790044802145 1607.9110200573048 1733.309076974096 1855.4634742150022 0.9533376831677205 0.892353957925163 0.9723632655009217 1.0241491206883637 0.9698873229518752 1.1112098696887962 0.9741927176685349 0.8665818769283883 0.9341650218727229 1.0 10.85756388575813 -1.5233641735935302 9.289264980549014 0.9695961289035973 0.00018936026140714546 0.0 0.06487043689335088 0.0 0.0 0.01603805451224883 0.0 0.02996648653323005 1.5233641735935302 -0.9694067686421901 AT(ph)SFEESER ddPTM_A459_Selumetinib_30min_R2 1 ATSFEESER 9 0 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 AT(0.534)S(0.466)FEESER 161.51 0.0021646 40775000.0 79241.0 84019.0 99548.0 116910.0 108350.0 59441.0 54756.0 68088.0 85804.0 93394.0 True False 74837.10244685622 90462.98713633478 93143.19005966737 100986.65631900105 94738.10433871004 67628.45819832588 57302.26249695564 68286.12480742473 102967.19756407231 90697.47255324607 0.8251288634633269 0.9974146422131704 1.0269656632932684 1.1134450991422553 1.0445506547394892 0.7456487627990186 0.631795582432741 0.7528999748844794 1.1352818845489108 1.0 16.46877472759428 -6.753298483781431 24.98232948646029 0.8238483819780478 1.0089078083531626 0.1849274850761764 0.14915922164314427 260.94977050010704 800787.135631818 0.05142385156542401 0.05057322187257735 1.7648244676158922e-07 6.753298483781431 0.18505942637511485 AT(ph)SNVFAMFDQSQIQEFK ddPTM_A459_Selumetinib_30min_R1 7 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;J3KTJ1;P24844;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 1 AT(0.959)S(0.041)NVFAMFDQSQIQEFK;AT(0.5)S(0.5)NVFAMFDQSQIQEFK;AT(0.804)S(0.196)NVFAMFDQSQIQEFK;AT(0.959)S(0.041)NVFAMFDQSQIQEFK;AT(0.541)S(0.459)NVFAMFDQSQIQEFK;AT(0.5)S(0.5)NVFAMFDQSQIQEFK;AT(0.5)S(0.5)NVFAMFDQSQIQEFK 245.41 9.8064e-26 638532000.0 31552.5 29006.2 33671.1 31148.4 29420.4 30596.9 29963.800000000003 29221.9 19357.26 22941.699999999997 True False 32287.611859522527 25610.14061938346 29098.749562113135 25708.916667883364 26759.33001459349 30289.122965762424 27703.60644200622 28446.840285891398 32847.85642166704 25886.490666081834 1.247276514843623 0.9893245457538797 1.1240901649229809 0.9931402830731653 1.033717948090017 1.1700745132459844 1.0701955239651426 1.098906787051066 1.2689188675816319 1.0 14.65991177731725 -6.755803772508815 24.996723946012064 1.1245868362128357 1.0705113032853046 0.04833021508734614 0.09491500577771106 400.51355196937175 1776477.8597296164 0.03048735387053623 0.029697060138125786 1.7546731375939163e-07 6.755803772508815 -0.05407553292753109 AT(ph)SNVFAMFDQSQIQEFK ddPTM_A459_Selumetinib_30min_R2 3 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;J3KTJ1;P24844;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 1 AT(0.5)S(0.5)NVFAMFDQSQIQEFK;AT(0.5)S(0.5)NVFAMFDQSQIQEFK;AT(0.5)S(0.5)NVFAMFDQSQIQEFK 194.68 4.4379e-10 53937800.0 164401.0 151682.0 138295.0 179781.0 146217.0 136076.0 155095.0 135969.0 124641.0 121437.0 True False 155264.2505693467 163315.5216654983 129397.25026421115 155294.5176604766 127847.91326343479 154819.23382506016 162307.22481491207 136364.64727912025 149572.68276051848 117930.7982787823 1.316570843540888 1.3848419924999478 1.0972303431570332 1.3168274948276733 1.084092663913026 1.312797302186283 1.376292089800208 1.1563107285745773 1.2683089145800268 1.0 16.847581009732117 -13.114517221443222 0.3655902233646113 6.807608863688207e-10 1.2627239719284273 0.3594537027784446 0.10310532063994496 185.1002684472135 3.9373257852674457 141.81628249551375 0.07356372804817111 7.682149924020795e-14 13.114517221443222 1.2627239712476666 AT(ph)SPEAGGGGGALK ddPTM_A459_Selumetinib_30min_R2 2 ATSPEAGGGGGALK 14 0 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 AT(0.853)S(0.147)PEAGGGGGALK;AT(0.632)S(0.368)PEAGGGGGALK 170.95 0.00035079 26813500.0 117183.0 105565.0 119259.0 124846.0 128175.0 97449.0 100525.0 107582.0 88010.0 111760.0 True False 110670.43798071636 113661.49605502501 111586.00577938167 107841.75942863722 112072.5106009615 110871.71519605418 105199.61168650862 107895.04580884102 105614.45920486188 108533.1984126474 1.0196920352420011 1.0472509583922849 1.0281278669695826 0.9936292397706616 1.0326104108243221 1.0215465573447458 0.9692850964046563 0.9941202082575684 0.9731074063008043 1.0 16.727776879865957 -7.224236189664239 10.546631888725296 0.9836453301142275 1.0241180341443012 0.6242806965848944 0.015078202688605435 0.5050272396646965 141.8964796058012 0.005847980855265427 0.004512735273814459 5.967106791301064e-08 7.224236189664239 0.04047270403007375 AT(ph)SPLCTSTASMVSSSPSTPSNIPQKPSQPAAK ddPTM_A459_Selumetinib_30min_R2 1 ATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAK 33 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 AT(0.471)S(0.471)PLCT(0.048)S(0.001)T(0.005)AS(0.005)MVSSSPSTPSNIPQKPSQPAAK 89.87899999999998 8.4064e-09 10759000.0 128430.0 111380.0 127860.0 149520.0 145590.0 112950.0 122860.0 123660.0 113270.0 135230.0 True False 121292.3747460245 119922.48785685303 119633.62680344192 129155.11806361329 127299.68260888613 128507.83724198632 128573.23344247146 124019.83012698485 135927.16502823203 131325.55853026386 0.9236006768482373 0.9131694484986104 0.9109698686404022 0.9834728251610642 0.9693443076394761 0.9785439992046315 0.9790419692967982 0.9443693330906685 1.035039687243422 1.0 17.002788194753755 -5.762537221236691 24.99893049996898 0.9808640048349926 0.915638932085967 0.6662860965738209 0.022073858850736885 16.759946608748788 381656.8804546356 0.005827071059618483 0.009221970303472465 1.7276779034158997e-06 5.762537221236691 -0.06522507274902556 AT(ph)SPLVSLYPALECR ddPTM_A459_Selumetinib_30min_R1 1 ATSPLVSLYPALECR 15 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3;Q96G74-4 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 AT(0.5)S(0.5)PLVSLYPALECR 195.94 7.7232e-05 15042000.0 1161.2 1221.9 1474.9 1477.7 1240.2 1398.8 1347.1 1150.5 706.76 1141.7 True False 1188.2537006981242 1078.8393799541016 1274.6166810457828 1219.6474348644315 1128.0241289750943 1384.729342008782 1245.4871624435684 1119.9850026493164 1199.3201002919516 1288.2483160997488 0.9223793936681677 0.837446761211654 0.9894184724454083 0.9467487126682139 0.875626317440303 1.0748931900032561 0.9668067459341672 0.8693859628244188 0.9309696626834857 1.0 10.331194991372994 -5.264497957923704 24.956629115035724 0.9533931469428027 0.8799130779731065 0.20772528329504025 0.059725066192079214 400.41513135052463 3267240.4705334 0.01587713835016658 0.035536624080709525 5.438786890615988e-06 5.264497957923704 -0.07348006896969628 AT(ph)SPLVSLYPALECR ddPTM_A459_Selumetinib_30min_R2 4 ATSPLVSLYPALECR 15 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3;Q96G74-4 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 AT(0.628)S(0.372)PLVSLYPALECR;AT(0.636)S(0.364)PLVSLYPALECR;AT(0.5)S(0.5)PLVSLYPALECR;AT(0.5)S(0.5)PLVSLYPALECR 241.41 7.9699e-20 199132000.0 105545.0 96017.0 107279.0 107677.0 117140.0 82822.0 87557.0 84894.5 77624.0 111932.0 True False 99679.23143011103 103381.19515668394 100376.7859365438 93011.20684681454 102423.82595511319 94229.97871674004 91628.57399090397 85141.5289399589 93150.9689957758 108700.23232573782 0.9170102887306266 0.9510669199573142 0.923427519784397 0.8556670474087988 0.9422594944248476 0.8668792761579817 0.8429473611088901 0.7832690613283929 0.8569528050007645 1.0 16.729995498287145 -6.897017440138673 5.771618930425431 0.8530493766796979 0.916364564453521 0.12131969789884012 0.056757684427249884 0.3239990494854638 15.577806840348883 0.019585663620667958 0.017253684758378508 1.2676009612726933e-07 6.897017440138673 0.06331518777382306 AT(ph)TPADGEEPAPEAEALAAAR ddPTM_A459_Selumetinib_30min_R1 1 ATTPADGEEPAPEAEALAAAR 21 0 Q5JZ02;Q96S44 Q5JZ02 TP53RK TP53-regulating kinase 1 AT(0.5)T(0.5)PADGEEPAPEAEALAAAR 196.65 1.6428000000000003e-23 0.0 518.4 662.43 569.45 647.85 503.32 502.87 594.29 381.17 207.91 133.32 True False 530.4777113691938 584.8723876446477 492.12181776494765 534.715159150654 457.7947948683633 497.8115843694279 549.4622268343762 371.0601333853454 352.8080848544056 150.43292064677112 3.5263405715215694 3.8879281551541247 3.2713704929022165 3.554508925650717 3.0431822562516295 3.3091931089892914 3.652539779670693 2.4666152314932788 2.3452850834614054 1.0 7.2329765098263925 -8.485647028216809 0.832553206696508 0.9979093843874448 3.506117126571694 0.8892796676576864 0.2720124502256462 0.194781311855961 0.3025526159250989 0.2629323065316435 0.09553533558600706 3.2685337353252225e-09 8.485647028216809 2.5082077421842492 AT(ph)TPADGEEPAPEAEALAAAR ddPTM_A459_Selumetinib_30min_R2 1 ATTPADGEEPAPEAEALAAAR 21 0 Q5JZ02;Q96S44 Q5JZ02 TP53RK TP53-regulating kinase 1 AT(0.589)T(0.411)PADGEEPAPEAEALAAAR 151.31 3.524e-06 2780300.0 7655.3 7318.5 9596.2 11116.0 12542.0 7145.5 7245.2 8036.4 7954.9 7033.7 True False 7229.8490725939555 7879.8054173135215 8978.790939552571 9601.981623830434 10966.361833097388 8129.727764609236 7582.116156091436 8059.7845935023615 9546.102278476954 6830.618805252675 1.0584471595800773 1.153600521705886 1.314491584956838 1.405726464554955 1.6054712092357386 1.1901890584726467 1.1100189268739264 1.1799494047749335 1.3975457496085275 1.0 12.737800566959272 -6.953637600940137 24.999940475560315 1.1816186925962153 1.3141344182470676 0.13840522835384028 0.16405871490940246 281.74707368447696 151925.1768837597 0.06214420542472908 0.054806020626514254 1.112659804181694e-07 6.953637600940137 0.13251572565085223 AT(ph)TPASTANSDVATIPTDTPLKEENEGFVK ddPTM_A459_Selumetinib_30min_R2 1 ATTPASTANSDVATIPTDTPLKEENEGFVK 30 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 AT(0.248)T(0.215)PAS(0.233)T(0.233)ANS(0.069)DVAT(0.002)IPTDTPLKEENEGFVK 89.694 1.8077e-06 6314500.0 46648.0 39844.0 42195.0 49501.0 46638.0 32852.0 41296.0 42894.0 42344.0 42296.0 True False 44055.49090673953 42899.906681347275 39480.219638442395 42758.87840601206 40778.91749098993 37377.064799236265 43216.345826471596 43018.81443851601 50813.98319021339 41074.80458179439 1.0725672673380475 1.044433616133668 0.9611785141868023 1.0410001664369233 0.9927963846981853 0.909975474741587 1.0521375881512143 1.0473285235685155 1.2371083370348084 1.0 15.325966090950075 -8.026092249137754 12.232007669781153 1.1264729402904203 1.0096681958615017 0.27124623985283913 0.06982869395516901 1.6418035714611448 764.52198988088 0.043906234893376694 0.017234604298743864 9.41689549597646e-09 8.026092249137754 -0.11680474442891864 ATAGAYIASQT(ph)VK ddPTM_A459_Selumetinib_30min_R2 2 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 ATAGAYIAS(0.391)QT(0.609)VK;ATAGAYIAS(0.092)QT(0.908)VK 115.1 0.009517200000000002 5648500.0 43360.0 39252.0 42356.0 43056.0 44922.0 36684.0 38563.0 48815.0 30606.0 38166.0 True False 40950.224783832666 42262.5021849273 39630.8610737259 37191.698524257175 39278.496752224615 41736.88801580367 40356.25591113484 48957.04356824172 36728.05520309063 37064.04841282308 1.1048502939485985 1.140255962171302 1.0692534348194618 1.0034440412448289 1.0597465315913897 1.1260747220847014 1.0888248218770604 1.3208768514155085 0.990934794656263 1.0 15.177732851473541 -6.771663892463247 23.34143122166157 1.1243647303241036 1.0747557915141177 0.004907974871451337 0.09148225558524078 291.64476763058747 665784.5454965027 0.03141914206716728 0.028059061473080637 1.6917496976440652e-07 6.771663892463247 -0.04960893880998585 ATAGDTHLGGEDFDNR ddPTM_A459_Selumetinib_30min_R1 4 ATAGDTHLGGEDFDNR 16 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37;P17066;P48741;Q53FA3;P34931 A0A0G2JIW1;P17066;Q53FA3 HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 0 ;;; 277.82 2.7448e-61 451115000.0 23773.9 25620.5 26957.300000000003 27673.5 26718.399999999998 21815.7 25190.4 23836.3 13127.080000000002 20764.0 False True 24327.78561404334 22620.83994935269 23296.646725849547 22840.84272093175 24301.72543751664 21596.253865070776 23290.26784709262 23204.083892785646 22275.69599601064 23429.261658487525 1.0383505024039166 0.9654952118885071 0.9943397732898708 0.9748852974484318 1.0372382105653362 0.9217641673845611 0.9940675120957321 0.9903890370518652 0.9507638917823519 1.0 14.516023869882698 -6.74517382284752 24.999977358476425 0.9722131245286797 0.9980914948997343 0.19520051407364802 0.030583714298830108 476.3972140983646 732215.8721258433 0.009720917676879676 0.00969470637384596 1.798151075684882e-07 6.74517382284752 0.02587837037105456 ATAGDTHLGGEDFDNR ddPTM_A459_Selumetinib_30min_R2 3 ATAGDTHLGGEDFDNR 16 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37;P17066;P48741;Q53FA3;P34931 A0A0G2JIW1;P17066;Q53FA3 HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 0 ;; 145.7 0.0005168999999999999 260531000.0 523928.0 474260.0 526105.0 671782.0 706817.0 489605.0 486553.0 616862.0 492160.0 540555.0 False True 494810.1792099599 510634.2170137488 492255.9770798128 580284.1327114106 618020.3294358477 557043.6445583241 509178.6785864794 618656.966292999 590605.7520993638 524947.7726194406 0.9425893489192327 0.9727333720566744 0.9377237179681728 1.1054130772207047 1.177298698405717 1.0611410765279146 0.9699606420763063 1.1785114606848568 1.1250752606345886 1.0 19.001814369727903 -5.762269467365804 24.99983219214646 1.0932963663366657 0.9531872468098157 0.4886132110988144 0.06415456955689841 18.776475884218975 565528.2019573406 0.018393702536233868 0.02919558080862304 1.7287433903033235e-06 5.762269467365804 -0.14010911952685 ATANSQVMGS(ph)ANSTLR ddPTM_A459_Selumetinib_30min_R1 2 ATANSQVMGSANSTLR 16 0 J9JIE0;A8MXZ4;A0A0C4DFY5;Q9NQ84;Q9NQ84-2 J9JIE0 GPRC5C G-protein coupled receptor family C group 5 member C 1 ATANSQVMGS(0.897)ANS(0.079)T(0.024)LR;ATANSQVMGS(0.999)ANSTLR 185.71 7.7702e-07 9919900.0 2362.37 2316.05 2958.4 2549.2 3306.8999999999996 2424.2 2416.3 2887.3 1124.6999999999998 1637.21 True False 2417.408624628167 2044.8857892975655 2556.6655293279864 2104.030074410507 3007.7914788806156 2399.8147489974886 2234.0365456257105 2810.719424727832 1908.533755162089 1847.3618512758778 1.3085734248320584 1.1069221700584908 1.383954923374773 1.138937708904924 1.62815502377257 1.2990496406213325 1.2093118324830494 1.5214774640856705 1.0331131141654586 1.0 10.85125076598548 -10.52471730744782 8.34217394430292 0.9999999985910242 1.2993027844175233 0.19949129185026382 0.1750542622458201 4.3145234669812805e-09 2.8649062141946647e-10 0.16038714707472013 0.038899596963561524 2.9873265076814163e-11 10.52471730744782 0.29930278582649916 ATAPQTQHVS(ph)PMR ddPTM_A459_Selumetinib_30min_R1 30 ATAPQTQHVSPMR 13 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;P29692-3;E9PL71;E9PPR1;P29692-4;E9PQZ1;E9PK06 P29692 EEF1D Elongation factor 1-delta 1 ATAPQT(0.002)QHVS(0.998)PMR;ATAPQT(0.147)QHVS(0.853)PMR;ATAPQT(0.012)QHVS(0.988)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.001)QHVS(0.999)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.034)QHVS(0.966)PMR;ATAPQT(0.001)QHVS(0.999)PMR;ATAPQTQHVS(0.999)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.003)QHVS(0.997)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.003)QHVS(0.997)PMR;ATAPQT(0.014)QHVS(0.986)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.015)QHVS(0.985)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.001)QHVS(0.999)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.082)QHVS(0.918)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR 198.67 7.798600000000001e-05 8915718800.0 84508.59 99346.64999999998 102503.14000000001 110759.98000000003 101015.58000000003 85659.46000000004 93326.42 85814.67 50659.39 75408.29999999999 True False 86477.4757219087 87715.09803299537 88583.77659744472 91417.82871532491 91878.73862474911 84797.80360496693 86286.73300186818 83538.58618626697 85965.28481454686 85087.68984404381 1.0163335716413529 1.0308788285798722 1.041088044108482 1.0743954722814022 1.0798123535043969 0.9965930883820185 1.0140918522999283 0.9817940331836935 1.0103140063164435 1.0 16.37666280305178 -6.784013154276753 24.996025105869258 1.0002665314445085 1.0485492881025786 0.6084204227431155 0.019230351424949735 178.78803676340942 197971.18989452958 0.007438732365645969 0.006565300206771133 1.6443219178546176e-07 6.784013154276753 0.048282756658070136 ATAPQTQHVS(ph)PMR ddPTM_A459_Selumetinib_30min_R2 17 ATAPQTQHVSPMR 13 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;P29692-3;E9PL71;E9PPR1;P29692-4;E9PQZ1;E9PK06 P29692 EEF1D Elongation factor 1-delta 1 ATAPQTQHVS(1)PMR;ATAPQT(0.001)QHVS(0.999)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(0.999)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.001)QHVS(0.999)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.009)QHVS(0.991)PMR;ATAPQT(0.004)QHVS(0.996)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.38)QHVS(0.62)PMR;ATAPQTQHVS(1)PMR;ATAPQT(0.372)QHVS(0.628)PMR 145.94 0.00044946 11781831200.0 880289.2000000001 878421.7000000001 1039304.6 1050114.2000000002 1161550.7999999998 811281.8 790398.7000000001 888860.6 821113.1 1027439.3 True False 831366.2503408716 945793.8198190564 972436.8735452915 907086.8344119636 1015626.404108095 923028.5038670711 827153.8056953123 891447.0371872066 985358.663816927 997774.457801108 0.8332206179871889 0.9479034188782439 0.9746059001032604 0.9091100972969367 1.0178917651854198 0.9250873247459533 0.8289987774573736 0.8934354154061775 0.9875565125093071 1.0 19.928354212458906 ATAPVQS(ph)EVLVMQSEY(ph)R ddPTM_A459_Selumetinib_30min_R1 1 ATAPVQSEVLVMQSEYR 17 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 2 AT(0.001)APVQS(0.999)EVLVMQS(0.108)EY(0.892)R 90.498 0.006714100000000001 139720000.0 2675.9 3430.3 6243.5 6498.9 4840.3 4320.5 3938.3 3130.8 2222.1 2610.9 True False 2738.243263604986 3028.678881296794 5395.666993090614 5363.989114461968 4402.495719624371 4277.0396927001275 3641.2308602564817 3047.7610137283614 3770.741404237291 2946.0344473196433 0.9294674969249903 1.0280527724488564 1.831501664211595 1.820748945872722 1.4943802587338526 1.4517955472623403 1.2359770143113367 1.034529998962256 1.279937988392492 1.0 11.524558584243817 -7.40794519840278 3.304412130708838 1.118597165802387 1.4477335156048416 0.20989745935432613 0.27962109390148987 0.4545569339036606 9.275990592983314 0.1463057498391567 0.09154329266506844 3.90890217295808e-08 7.40794519840278 0.32913634980245465 ATAS(ph)SPTQQDGR ddPTM_A459_Selumetinib_30min_R2 2 ATASSPTQQDGR 12 0 Q9BV73;Q9BV73-2 Q9BV73 CEP250 Centrosome-associated protein CEP250 1 AT(0.001)AS(0.473)S(0.473)PT(0.053)QQDGR;ATAS(0.61)S(0.364)PT(0.026)QQDGR 179.46 0.00010388 15220700.0 35907.0 37163.0 36259.0 45960.0 44052.0 34355.0 34354.0 39707.0 31513.0 38867.0 True False 33911.432687109766 40013.282602121006 33926.13541581426 39700.16871457775 38517.79393012327 39087.0894063607 35951.52907115957 39822.54079615231 37816.48054678804 37744.80872140635 0.8984396486788249 1.0601002881603723 0.8988291785029925 1.0518047397618007 1.0204792456208298 1.0355619946271737 0.9524893697704779 1.0550468301503833 1.0018988525259382 1.0 15.203990614797936 -5.783059679461043 24.999070001317627 1.0173091814630808 0.9632206909999163 0.24682925005837475 0.05042271818067763 354.5862818827606 409998.91162124375 0.013302654061682425 0.01975063170382274 1.6479359214933619e-06 5.783059679461043 -0.05408849046316455 ATAVMPDGQFK ddPTM_A459_Selumetinib_30min_R1 1 ATAVMPDGQFK 11 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 167.09 0.00043788 0.0 3279.5 3729.4 3150.3 3493.0 3459.3 3599.2 3453.0 3491.8 2427.7 2758.2 False True 3355.905969203838 3292.7601142489757 2722.5065633592308 2883.0131217307 3146.4069257890214 3562.9953158121307 3192.53742997375 3399.1861210351008 4119.629587807419 3112.241837143143 1.0782921587752847 1.0580026509994924 0.8747734610040244 0.9263461108077443 1.0109776458365587 1.1448324077163468 1.0257999207748951 1.0921985818927733 1.3236855628124964 1.0 11.603738454141466 -6.657393487285653 4.954306146509907 1.117056428285192 0.9804789734571334 0.29939485821898104 0.09797920806182697 0.27931384249148944 11.123303129437817 0.03395642710290891 0.03371826686166044 2.200931431982165e-07 6.657393487285653 -0.1365774548280586 ATAVMPDGQFK ddPTM_A459_Selumetinib_30min_R2 1 ATAVMPDGQFK 11 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 153.1 0.007847100000000001 12707000.0 150770.0 130120.0 141080.0 157960.0 161340.0 117550.0 119270.0 125840.0 101820.0 135510.0 False True 142390.8069801304 140099.785598256 132003.06639629015 136445.57550380126 141071.02680209966 133741.44548734382 124816.29132902155 126206.17356606653 122186.8450885018 131597.47420273657 1.0820177806814577 1.0646084694788363 1.0030820667038693 1.0368403826170387 1.0719888634394936 1.0162918878010097 0.9484702657494166 0.9590318836335392 0.9284892877219137 1.0 17.005772273615165 -7.1052721900957705 3.5397541089415117 0.9556840900799466 1.0487890750992426 0.729964491994707 0.026463913625008904 0.13225938068149137 3.0509006857140424 0.010909189036443051 0.008359734684962735 7.847436495451787e-08 7.1052721900957705 0.09310498501929598 ATCAPQHGAPGPGPADASK ddPTM_A459_Selumetinib_30min_R2 1 ATCAPQHGAPGPGPADASK 19 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 120.79 0.00060891 4032800.0 17393.0 17796.0 17700.0 18310.0 18181.0 17433.0 15895.0 15389.0 15357.0 17266.0 False True 16426.366689695606 19160.895976841086 16561.201270302878 15816.146413488219 15896.940239797765 19834.237508982278 16634.148995344975 15433.779442213903 18428.82911043139 16767.485717544492 0.9796559225637532 1.1427411538983614 0.9876973536333017 0.9432628528759772 0.9480813347682866 1.182898726922959 0.9920479000581464 0.9204587797003412 1.099081246936657 1.0 14.033378752722658 -7.560079267695607 0.0031416003082675196 0.0305726026178005 2.003099896706192 0.00028879440835172243 0.08523751830795037 128907.32613594293 327.73080001840395 102595.2135571259 103162.6649958454 2.753726045697505e-08 7.560079267695607 1.9725272940883916 ATCFLPS(ph)PGEK ddPTM_A459_Selumetinib_30min_R2 2 ATCFLPSPGEK 11 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 ATCFLPS(1)PGEK;ATCFLPS(1)PGEK 105.03 0.01193 9406400.0 130563.0 148444.0 120873.0 129316.0 115929.0 77623.0 127112.0 104144.0 88968.0 113347.0 True False 123306.83114510016 159829.17747730928 113096.16277657197 111702.93771745737 101364.9626015904 88314.86365856315 133022.95986764962 104447.04179803276 106764.08597361833 110074.37759912634 1.1202137485088888 1.452010730956682 1.027452212252796 1.0147950881381496 0.9208769998295674 0.8023199002786285 1.208482507637685 0.9488769691563694 0.969926774080308 1.0 16.748119161208166 -5.401446506488218 6.211622050472106 0.9813481533619612 1.2839617973793218 0.4996355751468968 0.12055117860580856 0.17417642773828917 8.07856502411298 0.030921530919482916 0.06519581339384162 3.967833990674106e-06 5.401446506488218 0.3026136440173606 ATDEDMQS(ph)LASLMSMK ddPTM_A459_Selumetinib_30min_R1 1 ATDEDMQSLASLMSMK 16 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1;B5MC86;C9K0H9 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 AT(0.001)DEDMQS(0.883)LAS(0.117)LMSMK 235.79 1.8252999999999998e-16 20681000.0 1033.6 2859.4 1943.7 2692.4 1615.3 1700.7 2112.2 1649.6 518.06 1360.8 True False 1057.6808689645034 2524.620118701004 1679.7562159798567 2222.222882607426 1469.196400204377 1683.59250211205 1952.875053458024 1605.8472493440347 879.1099823946585 1535.4719353144772 0.6888311304419131 1.6441981521361646 1.093967383803618 1.447257244823753 0.9568370260726866 1.096465824865263 1.2718402782516889 1.0458330187683593 0.572534060816038 1.0 10.584466428266891 -8.04144010384448 6.320644669141299 0.788676550724858 1.1846557508176891 0.249703652719931 0.2632590503110898 0.2662963006399032 28.797442117982108 0.16404799903606695 0.06312727480946594 9.089916549094798e-09 8.04144010384448 0.39597920009283116 ATDEDMQSLAS(ph)LMSMK ddPTM_A459_Selumetinib_30min_R1 1 ATDEDMQSLASLMSMK 16 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1;B5MC86;C9K0H9 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 ATDEDMQS(0.239)LAS(0.76)LMSMK 265.6 6.6555e-40 17885000.0 1209.0 3532.7 2387.8 3103.9 2555.7 2253.2 2405.3 2028.2 676.99 1846.6 True False 1237.1673476955154 3119.0898416923264 2063.549875246539 2561.862132419102 2324.5373862454812 2230.534853741913 2223.8662844818605 1974.4055474779166 1148.8025846067242 2083.6290974071962 0.5937560332762718 1.4969506067915952 0.9903633414480326 1.2295192726992554 1.1156195645079365 1.0705047537095358 1.0673042948234746 0.9475801379116878 0.5513469676710978 1.0 11.024882773912655 -7.963238273249792 3.75365943915132 0.7654956073755064 1.0987515812120554 0.20752905479474404 0.23405470485814053 0.29010661650104136 8.578888440576023 0.14088183943543614 0.057709457406096676 1.0883328217596106e-08 7.963238273249792 0.33325597383654904 ATDHPHPSTPAT(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 ATDHPHPSTPATAR 14 0 H7BYJ3;O14578;O14578-4;O14578-3 H7BYJ3 CIT Citron Rho-interacting kinase 1 ATDHPHPS(0.303)T(0.303)PAT(0.394)AR 80.488 0.045919 1595100.0 7042.2 5253.6 12803.0 19777.0 23879.0 13590.0 11325.0 12533.0 12813.0 13655.0 True False 6650.8227161602 5656.534227013507 11979.26891885242 17083.338482772066 20879.106539031454 15461.899142262899 11851.634940061775 12569.468955050159 15375.958025132344 13260.744670049238 0.5015421744136112 0.4265623362607512 0.9033632135236596 1.288263887725442 1.5745048305008897 1.165990261254724 0.8937382654557792 0.9478705206834729 1.159509394661714 1.0 13.694874173221782 -5.42054777287639 3.376328489477229 1.151455597459404 0.4637684686140945 0.6831178888237499 0.18369440930259398 0.15335748166928 3.2347866253840585 0.05703726020161276 0.13103044354796067 3.797101681328344e-06 5.42054777287639 -0.6876871288453096 ATDIPAS(ph)ASPPPVAGVPFFK ddPTM_A459_Selumetinib_30min_R1 1 ATDIPASASPPPVAGVPFFK 20 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 ATDIPAS(0.5)AS(0.5)PPPVAGVPFFK 183.71 9.0104e-14 91103000.0 5582.6 6847.7 5925.7 5754.5 6828.7 5684.9 7170.7 6271.9 3504.1 4907.2 True False 5712.6637181513515 6045.968100590636 5121.022487540171 4749.584600343348 6211.0452907049075 5627.715067476207 6629.808325836306 6105.548837997609 5946.201770661939 5537.086920175783 1.0317092363740596 1.0919041343852876 0.9248586055025476 0.8577767820543019 1.1217171375933048 1.0163674778104343 1.1973459007260505 1.1026644381814723 1.073886297322775 1.0 12.434911453870527 -6.30446890790052 24.999803842494654 1.0926160961554299 0.981107620714566 0.31859245929692415 0.07737533959724774 586.8760693870117 340968.7757834476 0.025080569021860195 0.028438848738928164 4.960564398989741e-07 6.30446890790052 -0.11150847544086384 ATDIPASAS(ph)PPPVAGVPFFK ddPTM_A459_Selumetinib_30min_R2 2 ATDIPASASPPPVAGVPFFK 20 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 ATDIPAS(0.002)AS(0.998)PPPVAGVPFFK;ATDIPAS(0.01)AS(0.99)PPPVAGVPFFK 156.06 1.7231e-06 108313000.0 608410.0 533630.0 656240.0 625400.0 654600.0 505720.0 531230.0 610430.0 472930.0 610210.0 True False 574597.0078582014 574557.7051091084 614018.2328600875 540219.4411248243 572363.2958017502 575378.3395309193 555933.2476122752 612206.2502378733 567529.2147682683 592591.6517840171 0.9696339901656693 0.9695676666712787 1.036157412969901 0.9116217542020303 0.9658645950860617 0.9709524894566495 0.9381388447485203 1.033099687440425 0.9577070703910568 1.0 19.176678776715363 -7.752118591066158 24.999780983576233 0.9965525402385365 0.9669220892208154 0.14767658141372908 0.034012353928098864 387.7537857065042 1040022.0268675992 0.015963228713309328 0.009054552926645743 1.7696256676953904e-08 7.752118591066158 -0.029630451017721104 ATDS(ph)FSGR ddPTM_A459_Selumetinib_30min_R2 3 ATDSFSGR 8 0 Q9HBH9;K7EK27;Q9HBH9-2 Q9HBH9 MKNK2 MAP kinase-interacting serine/threonine-protein kinase 2 1 ATDS(0.994)FS(0.006)GR;ATDS(1)FSGR;AT(0.004)DS(0.993)FS(0.003)GR 121.5 0.006862899999999999 17063200.0 111603.0 95623.0 98946.0 114305.0 131368.0 87265.0 105119.0 122149.0 98237.0 102784.0 True False 105400.5520422066 102956.9766235939 92579.92208425925 98736.46181287688 114864.37739517917 99284.96163720166 110007.241789347 122504.43336714436 117887.14497111738 99816.35885509629 1.0559446693023224 1.0314639584585215 0.9275024970471805 0.9891811617393588 1.1507570373502416 0.9946762512278567 1.1020963201938156 1.2272981580602877 1.1810403256870399 1.0 16.606988657086447 -7.476337926693112 5.099937656744182 1.155675213005887 1.0257956845225684 0.29820939170997807 0.07657675980989258 0.2192552224138622 13.26936365415208 0.034082539184707106 0.02181196675088007 3.339351023483433e-08 7.476337926693112 -0.12987952848331852 ATDSDLSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ATDSDLSSPR 10 0 Q9BRD0;Q9BRD0-2 Q9BRD0 BUD13 BUD13 homolog 1 ATDSDLS(0.004)S(0.996)PR;ATDSDLS(0.015)S(0.985)PR 158.56 0.00047333 71329000.0 12445.2 14534.2 14632.0 16461.0 16086.2 12685.099999999999 13948.5 13016.7 7414.9 10965.4 True False 12735.148945856263 12832.529107233737 12645.054767822829 13586.395361239363 14631.206050249275 12557.499411149263 12896.353414998226 12671.454831799534 12582.543737131131 12372.915902040988 1.0292762875528414 1.0371467169769524 1.0219947236315532 1.0980754632784826 1.1825188311379187 1.0149183515486295 1.0423051055306125 1.024128421474949 1.0169424763531743 1.0 13.59489791718596 -10.184602059805778 6.496588329930571 1.0000013893866824 1.0536178454716383 0.08991903617774033 0.0492910874112994 7.523202152960869e-11 0.0 0.0514193617956979 0.012471027052088935 6.53729284663149e-11 10.184602059805778 0.05361645608495591 ATDSDLSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 ATDSDLSSPR 10 0 Q9BRD0;Q9BRD0-2 Q9BRD0 BUD13 BUD13 homolog 1 ATDSDLS(0.029)S(0.971)PR 123.62 0.0040969 41268000.0 136820.0 139720.0 155910.0 154230.0 168860.0 129250.0 116560.0 125800.0 114110.0 129790.0 True False 129216.09213385583 150436.07472939056 145878.9203419733 133223.60793841045 147646.2971724466 147053.01428531847 121980.27095925824 126166.057172689 136935.1884997935 126042.62546508167 1.0251777258452406 1.193533331873246 1.1573776712734931 1.056972650695206 1.1713997278908628 1.166692725914833 0.9677699945487978 1.0009792854373818 1.0864196774267405 1.0 16.943552185523465 -7.2582102697488 24.999191932725545 1.013873845279037 1.1314884050584424 0.4967433410183336 0.05652774956272788 239.3479214339135 1852998.779388728 0.02203175570427038 0.016339259386129863 5.518102079625766e-08 7.2582102697488 0.11761455977940538 ATEDGEEDEVS(ph)AGEK ddPTM_A459_Selumetinib_30min_R2 1 ATEDGEEDEVSAGEK 15 0 Q9BXW9 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 ATEDGEEDEVS(1)AGEK 208.39 1.7100999999999994e-29 0.0 8409.1 6570.6 8142.7 11578.0 12970.0 12537.0 14138.0 16728.0 12823.0 8406.3 True False 7941.755886294451 7074.543892191059 7618.807547101428 10001.056426835978 11340.592646728837 14263.857950445174 14795.445013915527 16776.67571053052 15387.958304555683 8163.588276809587 0.9728266072475386 0.8665973408149219 0.9332670008290687 1.2250809432962353 1.389167638322012 1.7472534707519123 1.8123703097503268 2.05506146827471 1.8849503163049586 1.0 12.99498770784807 -6.320051262875573 1.3905041857103198 1.7826524728556294 0.9109228301645015 0.6014369133553196 0.2700080253417786 0.25067358666127415 0.9792039884916077 0.10128680362771572 0.13448465971663887 4.785735995329053e-07 6.320051262875573 -0.871729642691128 ATEMVEVGADDDEGGAER ddPTM_A459_Selumetinib_30min_R2 2 ATEMVEVGADDDEGGAER 18 0 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 0 ; 284.91 2.2361e-66 15998000.0 39592.0 32987.0 39706.0 40008.0 50691.0 40940.0 49723.0 52362.0 36566.0 37373.0 False True 37391.63513933354 35516.99683007737 37151.35918862408 34558.84138235048 44322.743396710255 46579.11338368231 52035.21802425534 52514.36475100427 43880.22173940442 36293.9443832845 1.0302444601902954 0.978592914977713 1.0236241835906508 0.9521930440348298 1.2212159397346598 1.283385263717292 1.4337162551067506 1.4469180918012932 1.2090232264645737 1.0 15.147441235291248 -6.418755545864283 3.192848776524704 1.310175292801423 0.9965747189347544 0.5356553590112538 0.12107581293711261 0.17880783770874234 3.460505865600825 0.03906345026224477 0.04419763808603564 3.8128037674906355e-07 6.418755545864283 -0.3136005738666686 ATEMVEVGADDDEGGAERGEAGDLR ddPTM_A459_Selumetinib_30min_R1 1 ATEMVEVGADDDEGGAERGEAGDLR 25 1 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 0 118.84 2.1851e-07 5355900.0 547.17 621.94 757.53 1013.9 867.86 560.22 622.59 345.17 353.71 401.54 False True 559.9179963925185 549.1229756679384 654.6615868144365 836.8413982601654 789.3622162331274 554.5846954390621 575.6275350499152 336.014970329826 600.2200360437297 453.0815703308168 1.235799540430866 1.2119737628414173 1.44490888547163 1.8469994214268017 1.7422077345957279 1.2240283687419309 1.2704721903158003 0.7416213598899756 1.3247504982501936 1.0 8.823626998363642 -7.212267888614596 2.300379828148368 1.0387604995869937 1.490540888384782 0.3953474186193191 0.2379596714489446 0.3341119763237264 3.464221564674818 0.11987492673528553 0.08153140528289425 6.133835312019421e-08 7.212267888614596 0.45178038879778826 ATEPPS(ph)PDAGELSLASR ddPTM_A459_Selumetinib_30min_R1 2 ATEPPSPDAGELSLASR 17 0 Q8IYB8 Q8IYB8 SUPV3L1 ATP-dependent RNA helicase SUPV3L1, mitochondrial 1 ATEPPS(1)PDAGELSLASR;ATEPPS(1)PDAGELSLASR 289.59 1.0406999999999998e-75 22672000.0 3387.8999999999996 5052.8 4470.9 5365.9 4061.1 4467.3 4058.3999999999996 3064.0 1830.78 2690.0 True False 3466.831478294155 4461.215827017007 3863.776336895782 4428.84629541791 3693.774222045438 4422.3630179838665 3752.271620563413 2982.7327667253417 3106.699945119275 3035.2877028188896 1.1421755753415033 1.469783514384435 1.2729522586302018 1.45911911128056 1.2169436915699978 1.4569831432706666 1.2362161310371522 0.9826853526785155 1.0235273388529411 1.0 11.567617554934856 -7.644035697640206 3.876436611928282 1.0016335546003536 1.3403490027644904 0.6777931588587143 0.10277423995028347 0.11976035094511138 3.34167030959615 0.048517963039001875 0.026146130716234006 2.269678283801314e-08 7.644035697640206 0.3387154481641368 ATEPPS(ph)PDAGELSLASR ddPTM_A459_Selumetinib_30min_R2 2 ATEPPSPDAGELSLASR 17 0 Q8IYB8 Q8IYB8 SUPV3L1 ATP-dependent RNA helicase SUPV3L1, mitochondrial 1 ATEPPS(1)PDAGELSLASR;ATEPPS(1)PDAGELSLASR 210.91 3.1287e-09 8026600.0 26617.3 23894.8 28874.0 33030.0 28900.6 19649.9 30959.0 25713.8 23777.1 21523.2 True False 25138.017023494194 25727.45432610826 27016.278275634206 28531.257020071876 25269.848253357854 22356.495360967747 32398.654844094697 25788.622900851242 28533.184387682362 20901.76929201051 1.2026741216162473 1.2308744760637234 1.2925354738252184 1.3650163592121198 1.2089813020286755 1.0695982262857189 1.5500436537914881 1.2338009543866069 1.365108569951965 1.0 14.351337448208353 -5.05990332286915 4.173347487481213 1.274176815115019 1.2073230660574532 0.008963100055263684 0.14694281912598536 0.9765622099341038 33.698386756899936 0.0364244514166895 0.12071238295926642 8.711574944084184e-06 5.05990332286915 -0.0668537490575658 ATET(ph)SPLTR ddPTM_A459_Selumetinib_30min_R1 2 ATETSPLTR 9 0 O75037-3;O75037-4;O75037-2;O75037 O75037-3 KIF21B Kinesin-like protein KIF21B 1 AT(0.001)ET(0.499)S(0.499)PLTR;AT(0.127)ET(0.437)S(0.437)PLTR 131.09 0.0086235 27610000.0 11164.900000000001 13654.2 13378.2 15043.8 14731.699999999999 11944.7 13364.3 11849.3 6943.599999999999 10942.1 True False 11425.020446886398 12055.559916334629 11561.513921192423 12416.68273710058 13399.220336092872 11824.547162919858 12356.220091340343 11535.01807204915 11782.782059521192 12346.625120079769 0.925355741813645 0.9764255251200775 0.936410866026013 1.0056742321354581 1.0852536791046834 0.9577149259751285 1.0007771331167228 0.934264866703479 0.9543322118332096 1.0 13.591829122743203 -5.760082185824019 24.999740978825642 0.991335907473309 0.9491001886238082 0.2052399972850264 0.04051984743195265 66.76691813836966 1229801.9476756922 0.01200373259520554 0.019416637944672133 1.7374719986904373e-06 5.760082185824019 -0.042235718849500836 ATEVSKT(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 1 ATEVSKTPEAR 11 1 Q5H909;Q9UNF1-2;Q9UNF1 Q5H909 MAGED2 Melanoma-associated antigen D2 1 AT(0.001)EVS(0.015)KT(0.984)PEAR 148.89 0.020971 0.0 3036.7 3114.0 3192.8 3318.0 2748.0 2704.6 2549.6 2652.0 1722.0 2389.4 True False 3107.4492016103964 2749.4114323406766 2759.235296795022 2738.573586573854 2499.4438851988043 2677.394179580319 2357.281619305264 2581.6603450899497 2922.1082300961302 2696.1027647269343 1.1525707559315248 1.019772490986315 1.0234162187339628 1.015752671746257 0.9270580921094645 0.993060878319855 0.8743292912071225 0.9575526492779753 1.0838267251256226 1.0 11.396659772033633 -1.5228795191758668 0.7586873095160002 0.9704763119681717 34.52700288273223 0.47680480568092853 0.05326700307830451 341.2481129187819 1.4193405918755209 0.020076073371228558 19592.207858219044 0.029999946541238352 1.5228795191758668 33.55652657076406 ATFSGS(ph)AGR ddPTM_A459_Selumetinib_30min_R1 1 ATFSGSAGR 9 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 ATFS(0.001)GS(0.999)AGR 97.597 0.02045 10654000.0 1690.9 2045.3 2276.4 2597.5 2911.9 1757.4 2298.1 2045.9 1052.0 1300.7 True False 1730.2946800813463 1805.8353251658255 1967.2773833701403 2143.895386113797 2648.5191591377015 1739.722151591531 2124.752466789074 1991.6360859802146 1785.1671649600053 1467.6575148909026 1.1789498997727454 1.2304201128967482 1.3404199299973445 1.4607599963627496 1.8045893761083474 1.1853733816917444 1.4477168176030606 1.3570169237529925 1.2163376992572443 1.0 10.519299632124884 -8.557763447022152 1.9698530609256035 1.0009608051396093 1.384959280175648 0.31848715425782104 0.17156146694677207 0.4665712121350136 4.126745127101168 0.17234646867583317 0.04823438754575068 2.768449163007834e-09 8.557763447022152 0.3839984750360388 ATGAALT(ph)PTEER ddPTM_A459_Selumetinib_30min_R1 2 ATGAALTPTEER 12 0 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 ATGAALT(0.681)PT(0.319)EER;ATGAALT(0.643)PT(0.357)EER 106.32 0.02093 16826000.0 3120.1 3584.2 3338.4 3824.6 3537.8 2954.0 3292.8 2939.0 1640.3200000000002 2672.7 True False 3192.7922593422495 3164.5601977506262 2885.063616518574 3156.705406633622 3217.806614649319 2924.2854420174017 3044.42144495151 2861.0481727825645 2783.503235767297 3015.767079302618 1.058699884767151 1.0493383986678493 0.9566599610158657 1.0467338238083013 1.0669944097252435 0.9696655494673112 1.0095015181528932 0.9486966657399046 0.9229834939411067 1.0 11.558309292011582 -7.286496842955631 1.457616531841567 0.9550831939573191 1.0306995138359014 0.3953309725261427 0.038030315531906715 0.4341002346430005 1.7950035306145813 0.02334660932609652 0.013513656989597523 5.170150163249806e-08 7.286496842955631 0.0756163198785823 ATGAALT(ph)PTEER ddPTM_A459_Selumetinib_30min_R2 1 ATGAALTPTEER 12 0 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 ATGAALT(0.705)PT(0.295)EER 122.52 0.0082361 14368000.0 67209.0 50347.0 55627.0 76466.0 80332.0 82771.0 64194.0 64312.0 41915.0 58505.0 True False 63473.79283894389 54208.4530088794 52048.01938209822 66051.1988887924 70239.97598280807 94171.9539296719 67179.14819799787 64499.13727257525 50299.171202951875 56815.808635754656 1.117185416577866 0.9541086241755181 0.9160834041063699 1.1625496578293146 1.2362752140538131 1.657495619457024 1.182402394880665 1.1352322323893744 0.8853023904916878 1.0 15.794004785813835 -5.893376973629326 5.433200411322569 1.2120328464259904 0.993016734870147 0.14779230565082446 0.19511781098545528 0.36139684594433813 15.991352423482335 0.05913213327699009 0.08909701585681869 1.2782712652883946e-06 5.893376973629326 -0.21901611155584344 ATGDGS(ph)SPELPSLER ddPTM_A459_Selumetinib_30min_R2 1 ATGDGSSPELPSLER 15 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BS99 H3BSS6 ZNF106 Zinc finger protein 106 1 ATGDGS(0.728)S(0.272)PELPSLER 148.57 0.00030202 5902000.0 25461.0 28941.0 29973.0 31098.0 31606.0 24996.0 24379.0 30794.0 27708.0 27760.0 True False 24045.979548458545 31160.681640017865 28044.56981213491 26862.398752957768 27635.371718775 28438.97210890384 25512.671806072038 30883.605441778862 33250.37422620518 26958.496670858065 0.8919629251601433 1.155876086877735 1.0402868585194842 0.9964353383991111 1.0251080413044187 1.0549168396191082 0.9463684907048636 1.1455982067117196 1.2333912618409686 1.0 14.718452427034757 -7.786604092927127 24.91346236282299 1.1421211849675317 1.0232879602819103 0.255722456731309 0.08443752853125096 279.5889255882129 276793.2228567832 0.043651746347502705 0.02098345272562541 1.6345413326958623e-08 7.786604092927127 -0.11883322468562141 ATGDGSS(ph)PELPSLER ddPTM_A459_Selumetinib_30min_R1 2 ATGDGSSPELPSLER 15 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BS99 H3BSS6 ZNF106 Zinc finger protein 106 1 ATGDGS(0.146)S(0.854)PELPSLER;ATGDGS(0.021)S(0.979)PELPSLER 216.0 3.7364000000000005e-09 16227600.0 3563.3 4546.7 4082.2 4198.6 4264.4 3720.7 4268.9 3573.8 1995.05 2963.2 True False 3646.3179570251705 4014.3702502965134 3527.859661919518 3465.393327483116 3878.6857729409703 3683.2731361253045 3946.8934360888907 3479.0112146615616 3385.454137313173 3343.5555840122424 1.0905510213320921 1.2006291354903387 1.0551221815448668 1.036439574701094 1.1600482407074493 1.1016036801474087 1.1804479802763281 1.0405124506668955 1.0125311370629744 1.0 11.707167385863743 -7.941172786496837 7.296362465094721 1.0127533397027106 1.116395747227432 0.4720237073420913 0.04930749138708066 0.1942103758962249 19.89847386082506 0.02782632797814453 0.013213491089850257 1.145057283342368e-08 7.941172786496837 0.10364240752472131 ATGDGSS(ph)PELPSLER ddPTM_A459_Selumetinib_30min_R2 1 ATGDGSSPELPSLER 15 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BS99 H3BSS6 ZNF106 Zinc finger protein 106 1 AT(0.001)GDGS(0.229)S(0.77)PELPSLER 173.19 3.3961e-05 4721500.0 28427.0 24396.0 33571.0 34177.0 36375.0 25149.0 30724.0 29697.0 26172.0 29379.0 True False 26847.14114229728 26267.09475449623 31411.078409341106 29522.033641386533 31805.247303374083 28613.046470108122 32152.726878451034 29783.41335339701 31407.131306779327 28530.751934190877 0.9409896102361053 0.9206590423934145 1.1009551546974297 1.0347443246319672 1.1147707349857503 1.0028844152480476 1.1269498593172242 1.0439056573796417 1.1008168091476564 1.0 14.800230149512647 -5.255550185962911 24.993671490650506 1.067797709948428 0.9308243099200164 0.6098682117765134 0.04309919917789535 270.1509735180589 1146509.2360341852 0.009960836109786202 0.0248567394118833 5.552004558635182e-06 5.255550185962911 -0.13697340002841152 ATGEPGTFVCTSHLPAAAS(ph)ASPK ddPTM_A459_Selumetinib_30min_R1 2 ATGEPGTFVCTSHLPAAASASPK 23 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 ATGEPGTFVCTSHLPAAAS(0.503)AS(0.497)PK;ATGEPGTFVCTSHLPAAAS(0.925)AS(0.075)PK 187.61 2.6798e-22 109006000.0 7617.5 8813.5 10536.2 11346.3 7481.9 8241.9 7708.400000000001 8227.1 5516.8 7916.4 True False 7794.972928925222 7781.6113227150145 9105.44191120387 9364.88170142944 6805.163466036731 8158.993969046449 7126.9491819315535 8008.89058261294 9361.60666887011 8932.547052265965 0.8726484040123619 0.8711525701665365 1.0193556057333106 1.0483999296766986 0.7618390842184738 0.9134006147750114 0.7978630440153823 0.8965965178522384 1.0480332892839679 1.0 13.124855892900786 -8.25494044430361 23.76995514292368 1.0240166529577865 0.8985259312187293 0.27108567447586773 0.08287090216476374 338.2758487405913 1237272.025633853 0.06250058508437203 0.022287740242874467 5.559804947928333e-09 8.25494044430361 -0.1254907217390573 ATGEPGTFVCTSHLPAAAS(ph)ASPK ddPTM_A459_Selumetinib_30min_R2 2 ATGEPGTFVCTSHLPAAASASPK 23 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 ATGEPGTFVCTSHLPAAAS(0.999)AS(0.001)PK;ATGEPGTFVCTSHLPAAAS(0.974)AS(0.026)PK 153.36 1.9999e-08 57967000.0 249360.0 211792.0 220420.0 205305.0 196468.0 146430.0 183352.0 174602.0 117637.0 164815.0 True False 235501.5694671706 228035.76538138496 206238.41717515016 177342.10482912033 171785.93339379507 166599.403340806 191878.2313050953 175110.06291308303 141167.68705240721 160056.3627092027 1.471366495407871 1.4247216513078595 1.288536198650553 1.1079978441801974 1.0732840012483802 1.0408796034150232 1.1988166421956494 1.094052494690452 0.8819873490995591 1.0 17.288220503813626 -5.550242677209473 1.5356796065129088 1.056999055494143 1.476749585094238 0.822617516266047 0.07494836876321613 0.18224655518131977 0.8203870774938771 0.02424217557358994 0.07343165435880002 2.816808501294581e-06 5.550242677209473 0.41975052960009496 ATGEPGTFVCTSHLPAAASAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ATGEPGTFVCTSHLPAAASASPK 23 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 ATGEPGTFVCTSHLPAAAS(0.375)AS(0.625)PK;ATGEPGTFVCTSHLPAAAS(0.345)AS(0.655)PK 135.17 3.7939e-06 21202600.0 110512.0 96250.0 93596.0 95452.0 93955.0 65553.0 78874.0 78733.0 51028.0 79676.0 True False 104370.18545458741 103632.06550747104 87574.13525961971 82451.27293611552 82151.5329316429 74582.33071911408 82541.79728586604 78962.09999505027 61235.02584144639 77375.54685689074 1.3488781623427408 1.3393387151000407 1.1318063499000748 1.0655985810169788 1.0617247472717128 0.963900531224124 1.0667685158791897 1.020504580615035 0.7914002333928973 1.0 16.23959008025679 -4.8904695579203805 0.5451036019583265 0.954607046159424 1.6510616006507937 0.7971687013259242 0.07115968358135842 1.6104217571042776 0.3975411254991138 0.04169305474569688 0.7044954830912671 1.2868574527575489e-05 4.8904695579203805 0.6964545544913696 ATGHSGGGCISQGR ddPTM_A459_Selumetinib_30min_R2 1 ATGHSGGGCISQGR 14 0 I3L407;I3L3W5;I3L139;Q9HA64 I3L407 FN3KRP Ketosamine-3-kinase 0 87.447 0.030978 353220.0 405.11 0.0 0.0 512.37 687.02 753.78 0.0 0.0 0.0 429.04 False True 382.59560798382034 0.0 0.0 442.58432211245014 600.7104055632727 857.6063528664406 0.0 0.0 0.0 416.65250042020665 0.918260679098196 0.0 0.0 1.0622384881072127 1.4417539915335635 2.058325227861392 0.0 0.0 0.0 1.0 8.702700827818008 -5.762281587369191 24.99998530146038 0.7994596793501759 0.2754782066572228 0.09793627080847367 0.6774147412286602 58.38568498863324 1733212.6559095269 0.21150269942129551 0.3356228091928843 1.7286951463484495e-06 5.762281587369191 -0.5239814726929531 ATGPEAAGGGGAGGGGGGYRPIIQS(ph)PGYK ddPTM_A459_Selumetinib_30min_R1 1 ATGPEAAGGGGAGGGGGGYRPIIQSPGYK 29 1 Q9ULL5;Q9ULL5-2 Q9ULL5 PRR12 Proline-rich protein 12 1 AT(0.001)GPEAAGGGGAGGGGGGY(0.128)RPIIQS(0.859)PGY(0.013)K 46.787 0.022313 21368000.0 1036.9 1433.4 1337.6 1333.9 1290.9 787.27 1145.1 1302.2 710.67 996.44 True False 1061.0577525438216 1265.5768616304185 1155.961266910868 1100.9594054041177 1174.1383229269065 779.350778583967 1058.7241850747005 1267.6614258582704 1205.9550847168503 1124.3427801475289 0.9437137599661525 1.1256147893477448 1.0281217501651858 0.9792026282764559 1.04428857787733 0.693161189225323 0.9416382652768772 1.127468818443372 1.0725866755320053 1.0 10.13486622398218 -11.024600836759568 4.705918074148921 1.0000256732718231 0.9943201582630478 0.00011628629810844782 0.1187406998045369 3.420029733831938e-05 3.6210399805108353e-06 0.12293851468406095 0.029682785621632832 9.449289684283508e-12 11.024600836759568 -0.005705515008775364 ATGPEAAGGGGAGGGGGGYRPIIQS(ph)PGYK ddPTM_A459_Selumetinib_30min_R2 2 ATGPEAAGGGGAGGGGGGYRPIIQSPGYK 29 1 Q9ULL5;Q9ULL5-2 Q9ULL5 PRR12 Proline-rich protein 12 1 ATGPEAAGGGGAGGGGGGY(0.053)RPIIQS(0.799)PGY(0.147)K;ATGPEAAGGGGAGGGGGGY(0.009)RPIIQS(0.937)PGY(0.054)K 62.647 0.00095591 37031700.0 38345.0 31354.0 37326.0 36236.8 37594.0 27922.8 27919.7 34903.0 30756.4 34504.0 True False 36213.938407197034 33758.750980999954 34924.48579747601 31301.285328033344 32871.10562537578 31768.912242058756 29218.021371835985 35004.56195149731 36908.53940561775 33507.77986784173 1.0807620961468853 1.007489935595497 1.0422799103737077 0.9341497840647445 0.9809992113778632 0.9481055554070948 0.8719772389300332 1.0446696883398139 1.1014916401859203 1.0 15.032208480303634 -3.703167101515285 11.941911122409094 0.9962624029262873 1.000533372827216 0.0 0.0668364573519956 0.0 0.0 0.016075566492552915 0.0 0.00019807647493094892 3.703167101515285 0.004270969900928789 ATGPVLISTADFEGPMPSAPPEAES(ph)PLASTSK ddPTM_A459_Selumetinib_30min_R2 1 ATGPVLISTADFEGPMPSAPPEAESPLASTSK 32 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 ATGPVLISTADFEGPMPS(0.003)APPEAES(0.875)PLAS(0.068)T(0.032)S(0.021)K 56.903 0.0010478 1043000.0 5154.7 4071.7 4185.1 4669.0 5631.7 3815.1 5102.6 4680.5 4532.1 4406.3 True False 4868.222409899036 4383.986297420988 3915.8352223923466 4033.0741455257516 4924.195497963207 4340.595394970355 5339.881010610086 4694.119480101512 5438.646637454328 4279.078670057703 1.1376800440627068 1.0245164053882354 0.9151117622101447 0.9425099318100095 1.1507606841677451 1.0143761612384246 1.2479043790372937 1.0969930309877225 1.27098542859484 1.0 12.063084487544685 -6.73906149871155 1.583321520502728 1.154831077028777 1.0071459433577243 0.23511580727883263 0.10092425638495636 0.494851852105367 2.575559934379975 0.042985062989361396 0.03976991746973623 1.8236374460005627e-07 6.73906149871155 -0.14768513367105274 ATHGSNS(ph)LPSSAR ddPTM_A459_Selumetinib_30min_R1 3 ATHGSNSLPSSAR 13 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1;Q8TDM6-5 Q8TDM6-4 DLG5 Disks large homolog 5 1 ATHGS(0.122)NS(0.878)LPSSAR;AT(0.002)HGS(0.338)NS(0.659)LPSSAR;AT(0.001)HGS(0.049)NS(0.948)LPS(0.001)SAR 233.47 1.9685e-13 15667500.0 2157.43 2162.33 1671.47 1912.25 2925.6099999999997 1646.9899999999998 2318.5 1660.5500000000002 597.62 1082.8600000000001 True False 2207.6939213719907 1909.163398360056 1444.493554727504 1578.3114348781955 2660.9890920583966 1630.4227759472708 2143.61367836494 1616.5068197734233 1014.1174915621663 1221.8556289496144 1.8068369691678436 1.5625114400801146 1.1822129558541081 1.2917331618261754 2.1778261105577212 1.3343825058520924 1.7543919490780822 1.3229933074524332 0.8299814376875007 1.0 10.254858115069919 -8.072541055537073 3.870341297600439 0.9268536753898838 1.5719525505894882 0.48157229051863404 0.27605326449987416 0.21240502354296845 5.937284150879175 0.20704191130235267 0.07347315385294828 8.461725730601453e-09 8.072541055537073 0.6450988751996044 ATHGSNS(ph)LPSSAR ddPTM_A459_Selumetinib_30min_R2 2 ATHGSNSLPSSAR 13 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1;Q8TDM6-5 Q8TDM6-4 DLG5 Disks large homolog 5 1 ATHGS(0.021)NS(0.979)LPSSAR;ATHGSNS(1)LPSSAR 137.81 0.00067534 17125600.0 39516.0 29923.0 66549.0 82654.0 96271.0 66309.0 47179.0 54924.0 66633.0 81177.0 True False 37319.85891508144 32217.99788239019 62267.309793072614 71396.38261389724 84176.57630634014 75442.46285682931 49372.91698341499 55083.819746842324 79961.46188157672 78833.20908682431 0.47340276194996156 0.40868560668266524 0.7898614113817622 0.9056637861242411 1.0677806635225369 0.9569883521263159 0.6262959171056613 0.6987387724654823 1.0143118973313618 1.0 16.26651588349643 -5.346836322904765 3.763855067071929 0.8797108994341494 0.4373454412008857 0.6443145446578711 0.13247851572035302 0.1530528866955163 4.0335984780554295 0.038828139929841465 0.09113738847466485 4.499494000698257e-06 5.346836322904765 -0.4423654582332637 ATIS(ph)DEEIER ddPTM_A459_Selumetinib_30min_R1 2 ATISDEEIER 10 0 C9J0A7;Q9UQN3-2;Q9UQN3 C9J0A7 CHMP2B Charged multivesicular body protein 2b 1 AT(0.225)IS(0.775)DEEIER;AT(0.019)IS(0.981)DEEIER 168.83 0.00025373 903280000.0 3065.6000000000004 3592.0 3972.2 4046.1000000000004 3399.9 2851.9 3250.8 3208.5 1582.3 2355.3 True False 3137.022515380788 3171.4469701245025 3432.7970577327696 3339.524589703576 3092.3796453010964 2823.212475318018 3005.5895387659048 3123.4001573231926 2685.0475333804347 2657.6256975648053 1.180385378669109 1.1933384648675371 1.2916781550081553 1.2565819907459497 1.1635873509707022 1.0623062825983887 1.130930341891238 1.1752596161999709 1.0103181707795632 1.0 11.375922213093853 -6.5287951226129834 3.906923965539131 1.0906833907890634 1.2312243231316746 0.6145818251892694 0.057235007952250117 0.16528468829036067 5.7026158180661515 0.019439228890064015 0.020500309877009817 2.959408231082806e-07 6.5287951226129834 0.14054093234261122 ATIS(ph)DEEIER ddPTM_A459_Selumetinib_30min_R2 4 ATISDEEIER 10 0 C9J0A7;Q9UQN3-2;Q9UQN3 C9J0A7 CHMP2B Charged multivesicular body protein 2b 1 AT(0.226)IS(0.774)DEEIER;AT(0.213)IS(0.787)DEEIER;AT(0.007)IS(0.993)DEEIER;AT(0.057)IS(0.943)DEEIER 158.34 0.00047709 1000313400.0 258635.0 209762.0 282638.0 267047.0 243369.0 194813.0 184489.0 189884.0 172737.0 214845.0 True False 244261.1020979369 225850.07090886362 264453.37879298715 230674.7379182297 212794.8104735351 221646.7224136614 193068.10405801827 190436.53100301162 207289.22667504026 208641.86661565216 1.1707195016036758 1.082477235141456 1.2674991030450646 1.1056013908424487 1.0199046525285036 1.0623309981307156 0.92535648376688 0.9127436122579494 0.9935169294516347 1.0 17.670669156255606 -6.497702253715421 1.302775184561721 0.9576789153875359 1.1660972880029128 0.6953531409453482 0.05709065734664034 0.24299603866548758 0.8538567765136338 0.024830454632400276 0.02846710443193052 3.1790528383142574e-07 6.497702253715421 0.20841837261537688 ATISS(ph)PLELEGTVSR ddPTM_A459_Selumetinib_30min_R1 1 ATISSPLELEGTVSR 15 0 Q96GS4 Q96GS4 C17orf59 Uncharacterized protein C17orf59 1 AT(0.007)IS(0.405)S(0.588)PLELEGTVSR 91.845 0.014115 2006600.0 2130.6 2545.3 2785.3 2918.4 2636.1 2436.5 3208.7 4264.4 1708.1 2364.9 True False 2180.2388345740815 2247.2950927221336 2407.0715585577473 2408.756225152843 2397.6652204412558 2411.9910221649975 2966.665175660808 4151.294259276615 2898.520945311965 2668.457951076727 0.8170407308439511 0.8421699475591685 0.902045901673845 0.9026772275654207 0.8985208927402413 0.9038894621486373 1.1117526414323875 1.555690340783358 1.0862157090174147 1.0 11.381790562523433 -7.3723851122875965 3.643600665212325 1.253707868719887 0.878366397979157 0.5419131171209997 0.13963854533264627 0.16058958025051853 3.8772586080272826 0.05968229882817204 0.03850963998899399 4.242431978258093e-08 7.3723851122875965 -0.37534147074073 ATLLEDQQDPSPS(ph)S ddPTM_A459_Selumetinib_30min_R1 2 ATLLEDQQDPSPSS 14 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 ATLLEDQQDPS(0.007)PS(0.602)S(0.391);ATLLEDQQDPS(0.286)PS(0.45)S(0.264) 166.45 0.00023272 10585400.0 2693.2 3359.0 3476.9 4316.1 3752.1000000000004 2653.1 3494.5 3226.3 1708.28 2181.71 True False 2755.9463199450456 2965.726718443264 3004.7560772446145 3562.3741582312846 3412.7232174870587 2626.4122228220617 3230.9070515619096 3140.728043500642 2898.8263921652847 2461.7537301550183 1.1195052885210828 1.2047211230412191 1.220575413550974 1.4470879497791842 1.3862975713952335 1.0668866632149572 1.3124412129390608 1.2758091944895187 1.177545242099722 1.0 11.265470728834208 -8.632016584220946 3.0185120652681694 1.0001578355677783 1.2574833982472493 0.3391431021539627 0.10749491275254662 0.5419299060543015 10.839205955255895 0.10853863798715511 0.0288785591633981 2.3333689571995185e-09 8.632016584220946 0.25732556267947104 ATLLEDQQDPSPS(ph)S ddPTM_A459_Selumetinib_30min_R2 1 ATLLEDQQDPSPSS 14 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 ATLLEDQQDPS(0.014)PS(0.599)S(0.387) 125.84 0.0013466 3295400.0 24673.0 24166.0 25032.0 28303.0 28807.0 21018.0 19368.0 17355.0 18750.0 22788.0 True False 23301.773433844628 26019.45449406282 23421.468372780884 24448.082574601704 25188.007122152496 23913.03871759245 20268.65037696393 17405.50017672509 22500.523918772455 22130.051229665463 1.052947107623884 1.1757521129993402 1.0583558135366748 1.104745864385027 1.1381811483738378 1.0805686109545414 0.9158880911126716 0.7865097100811459 1.0167407063482243 1.0 14.433719170439787 -7.231941956643239 4.598120243475733 0.9108131542894004 1.106692634300722 0.6045338911974599 0.0676481093545203 0.1214725099284114 6.495124945628374 0.026106226671337412 0.019180546519531202 5.8621650697885594e-08 7.231941956643239 0.1958794800113216 ATLLNVPDLSDS(ph)IHSANASER ddPTM_A459_Selumetinib_30min_R1 1 ATLLNVPDLSDSIHSANASER 21 0 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 ATLLNVPDLS(0.295)DS(0.601)IHS(0.039)ANAS(0.065)ER 76.611 0.0018388 4959500.0 1356.8 1713.1 1100.6 1031.8 1308.8 1030.8 1523.6 1210.1 918.0 1405.4 True False 1388.4108001267787 1512.529455601416 951.1445651630539 851.6154992847808 1190.419271087407 1020.4310878915156 1408.6736253426025 1178.0042170412326 1557.77895193278 1585.7967797552667 0.8755288305863818 0.9537977847545144 0.5997896939290307 0.5370268814748187 0.7506758030314088 0.6434816244544254 0.8883065240932073 0.742846896954244 0.9823320187175493 1.0 10.630992185827347 -8.212686017775379 1.3247295744251464 1.0120463908361736 0.7319883048079043 0.3577170092990085 0.12665796600728702 0.5074004029327442 1.6989909309001952 0.1276878511323069 0.04066574305031588 6.1279326324345595e-09 8.212686017775379 -0.2800580860282693 ATLLNVPDLSDSIHSANAS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 ATLLNVPDLSDSIHSANASER 21 0 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 ATLLNVPDLS(0.004)DS(0.038)IHS(0.364)ANAS(0.593)ER 106.51 9.1747e-05 2936300.0 8693.9 5277.5 8260.0 10673.0 13653.0 8422.7 10724.0 12405.0 11980.0 8266.3 True False 8210.727842439179 5682.267280162892 7728.56059280801 9219.318988048059 11937.788080631366 9582.85047134199 11222.687249202863 12441.096496241698 14376.33474916767 8027.630440573271 1.0228083994674813 0.707838673220875 0.9627449407419528 1.1484483567469366 1.4870874000745433 1.1937333864932698 1.3980074608917132 1.549784408779193 1.7908565741276232 1.0 12.970758487084545 -5.9419864131502 1.9924622012062472 1.4243291846838948 0.8587663129297501 0.5353245624438449 0.21108315369698427 0.2418283287986864 1.9439367556652576 0.06698558461706677 0.11202833327473839 1.1429140901581251e-06 5.9419864131502 -0.5655628717541447 ATLPS(ph)PDKLPGFK ddPTM_A459_Selumetinib_30min_R2 1 ATLPSPDKLPGFK 13 1 P22314;P22314-2;Q5JRR6 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 ATLPS(1)PDKLPGFK 82.505 0.018098 15259000.0 117770.0 104910.0 106460.0 110710.0 99030.0 70210.0 91776.0 108110.0 65836.0 85380.0 True False 111224.81487066366 112956.25966118199 99610.47950488403 95631.10701459736 86588.96606056731 79880.79019707718 96043.76585069404 108424.58220142595 79005.03961153606 82914.85755611875 1.34143407043043 1.3623162722643587 1.201358627884819 1.1533651486993384 1.0443118231489674 0.9634074344638651 1.1583420472704706 1.3076616832880839 0.9528453879096829 1.0 16.33934302170413 -5.521210113046039 1.8063453064759278 1.08777561100357 1.3613552883429099 0.5393756656805017 0.09989370650758905 0.3129935579978291 1.9768002085630743 0.031052611816121928 0.0868543813302722 3.0115486748909906e-06 5.521210113046039 0.27357967733933997 ATLSSTSGLDLMSES(ph)GEGEISPQR ddPTM_A459_Selumetinib_30min_R1 1 ATLSSTSGLDLMSESGEGEISPQR 24 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 ATLSSTSGLDLMS(0.002)ES(0.976)GEGEIS(0.022)PQR 157.2 9.3516e-13 5407400.0 1707.8 1771.2 1406.1 1498.2 1942.8 1786.8 1910.0 1405.6 726.43 1569.4 True False 1747.5884171996702 1563.8270805914597 1215.1593431544343 1236.567494697091 1767.0740830291984 1768.826414284594 1765.9271622501783 1368.3189219677352 1232.6986536519937 1770.8477772505437 0.9868654096926465 0.883095148369834 0.686202032023959 0.6982912425239691 0.9978689900567261 0.9988585337532014 0.9972213224289638 0.7726914416620363 0.6961065030478837 1.0 10.790224487466537 -4.805667326501954 4.649473626905729 0.853262793555373 0.9919105466417385 0.08260326623963543 0.12950375067835476 0.5024821192618025 21.830795857258973 0.035265206449465736 0.2020733867651321 1.564345486583133e-05 4.805667326501954 0.13864775308636546 ATLSSTSGLDLMSES(ph)GEGEISPQR ddPTM_A459_Selumetinib_30min_R2 1 ATLSSTSGLDLMSESGEGEISPQR 24 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 ATLSSTSGLDLMS(0.006)ES(0.713)GEGEIS(0.28)PQR 73.212 0.00047265 2574700.0 23461.0 25705.0 29232.0 27262.0 31994.0 21559.0 22118.0 24435.0 23898.0 22501.0 True False 22157.13154182422 27676.490845397853 27351.244945395127 23548.86857042688 27974.627690010977 24528.556556883406 23146.530825985552 24506.101804567978 28678.267765910598 21851.337665381005 1.0139942863510678 1.266581079347175 1.2516965946999028 1.0776854456711484 1.280224950911407 1.1225196796873407 1.059272946143545 1.12149206514679 1.3124261866743963 1.0 14.415433978915647 ATLSSTSGLDLMSESGEGEIS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 ATLSSTSGLDLMSESGEGEISPQR 24 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 ATLSSTSGLDLMSES(0.003)GEGEIS(0.997)PQR 118.15 9.9472e-08 7551400.0 1520.9 1978.2 1568.3 1584.8 1473.0 1407.9 1858.0 1594.1 840.64 1487.1 True False 1556.3340108437621 1746.591424359769 1355.3334740552589 1308.0444303804227 1339.7674100792715 1393.737804270921 1717.8495641156185 1551.8192896334413 1426.5046820836303 1677.9837705806572 0.927502421733913 1.0408869590886272 0.8077154843912782 0.779533421784992 0.7984388368760279 0.8306026725089395 1.023758152035741 0.9248118586370133 0.8501302021473045 1.0 10.712513046794989 -7.237436310499562 24.944675263042107 0.9434093962619816 0.8627551854232036 0.1996634461184219 0.08351888614773836 1506.0794977800776 1565163.231155584 0.03535599348929045 0.02737060727203739 5.788468703046261e-08 7.237436310499562 -0.080654210838778 ATLSSTSGLDLMSESGEGEIS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 ATLSSTSGLDLMSESGEGEISPQR 24 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 ATLSSTSGLDLMS(0.001)ES(0.032)GEGEIS(0.966)PQR 66.906 0.01382 0.0 6681.5 4823.0 7089.6 7060.6 8279.8 5531.8 5826.3 5229.1 5926.4 6229.0 True False 6310.168978163694 5192.90859161073 6633.462854572844 6098.934099785632 7239.61750164884 6293.755237319343 6097.23449459443 5244.315815275894 7111.845597451362 6049.152585114363 1.0431492493166126 0.8584522407963948 1.0965937395754142 1.0082295022271004 1.196798625887525 1.0404358542396324 1.0079485363947316 0.8669504928973034 1.1756763443117724 1.0 12.562517336655553 -5.277961575884738 24.87393078132119 1.046366508909819 0.9508007217955102 0.13790979019221172 0.09809976399184904 1342.8325442549249 2021614.8160324972 0.025407875425152573 0.053133655613704575 5.272765100403208e-06 5.277961575884738 -0.09556578711430885 ATLSSTSGLDLMSESGEGEIS(ph)PQREVSR ddPTM_A459_Selumetinib_30min_R1 2 ATLSSTSGLDLMSESGEGEISPQREVSR 28 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 ATLSSTSGLDLMS(0.002)ES(0.03)GEGEIS(0.967)PQREVS(0.002)R;ATLSSTSGLDLMSES(0.001)GEGEIS(0.994)PQREVS(0.005)R 103.05 1.2332e-07 22761000.0 766.27 557.27 1464.3600000000001 2038.49 1303.94 978.6299999999999 599.01 767.69 509.24 473.46000000000004 True False 784.1226000981324 492.02456933220583 1265.5079551537071 1682.5059886964843 1185.9988572293041 968.7858707249453 553.8261934342825 747.3283673914417 864.1430865819708 534.2332028909407 1.4677534003033588 0.9209921185536059 2.36883059365378 3.149384912041781 2.220002146649459 1.8134138153197397 1.0366749772146633 1.3988804202871732 1.6175390857508691 1.0 9.061325832834074 -7.077129880754339 4.9282216896641575 1.3015944473088383 2.044224682809787 0.28639480883363366 0.5679078368005314 0.3501105270430726 15.316946306894282 0.25041289991510995 0.1949128054842651 8.372788468224935e-08 7.077129880754339 0.7426302355009489 ATLTAS(ph)PLGAS ddPTM_A459_Selumetinib_30min_R1 1 ATLTASPLGAS 11 0 Q13111;Q13111-3 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 AT(0.003)LT(0.014)AS(0.983)PLGAS 97.597 0.019082 7962100.0 7274.5 8316.6 8972.4 9351.2 8629.4 7177.1 7513.7 7234.6 4468.5 6786.1 True False 7443.9816962870345 7342.888605717558 7753.9973618653385 7718.1884637641415 7848.872293644312 7104.904890285406 6946.935559685423 7042.714906707293 7582.718133672797 7657.162037211627 0.9721593535713889 0.958956930783652 1.0126463726617145 1.0079698491759668 1.0250367245072036 0.9278770457981157 0.9072467744479344 0.9197552399285407 0.9902778727710014 1.0 12.902594071919074 -6.772506886638406 24.999985371734173 0.941404544710721 0.9949933820632928 0.3187305342126048 0.03292887969149814 237.9767650503623 537553.8119139982 0.01190813807493842 0.010597421398591258 1.6884690851004183e-07 6.772506886638406 0.053588837352571805 ATLTAS(ph)PLGAS ddPTM_A459_Selumetinib_30min_R2 1 ATLTASPLGAS 11 0 Q13111;Q13111-3 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 ATLTAS(1)PLGAS 242.97 1.6998e-10 3738000.0 61329.0 65070.0 67934.0 71671.0 73779.0 51877.0 56197.0 55750.0 56634.0 68412.0 True False 57920.57969943892 70060.65976697291 63563.200400946596 61909.28616062893 64510.222427371344 59022.585857481405 58810.27185224296 55912.22327009066 67962.38248617374 66436.7678042774 0.8718151351082105 1.0545464820530024 0.956747332865495 0.9318527707882113 0.9710018196161851 0.8884024284769818 0.8852066979763059 0.8415855424334905 1.022963409153058 1.0 16.01969426642335 -6.748095606288851 24.939398671513587 0.9150791526191507 0.9611687394622804 0.029380022564542196 0.06598107474165966 538.3724267236292 1006211.8235703112 0.02112392165973632 0.02100579264516863 1.786094337876742e-07 6.748095606288851 0.04608958684312969 ATNES(ph)EDEIPQLVPIGK ddPTM_A459_Selumetinib_30min_R1 14 ATNESEDEIPQLVPIGK 17 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AT(0.009)NES(0.991)EDEIPQLVPIGK;AT(0.007)NES(0.993)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.069)NES(0.931)EDEIPQLVPIGK;AT(0.333)NES(0.667)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.001)NES(0.999)EDEIPQLVPIGK;AT(0.002)NES(0.998)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.222)NES(0.778)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.006)NES(0.994)EDEIPQLVPIGK 252.79 9.098e-31 1706003500.0 148644.31000000003 171535.96 189083.91000000003 194749.68 180632.00999999998 157132.97 161281.16999999998 151928.69000000003 87197.86 130741.92 True False 152107.4332115216 151452.45005829562 163407.35358557184 160740.30429225753 164293.87658867147 155552.35498712168 149115.60149868493 147899.04760726396 147968.3997402848 147523.91896614514 1.0310696345209505 1.0266297907463537 1.1076668429820642 1.0895880845542436 1.1136761939355395 1.0544212496335523 1.0107893183945653 1.0025428326724761 1.003012940391325 1.0 17.170589360953393 -7.204159978786494 3.3640097070894597 1.003181922313806 1.0745219268023773 0.6029834956556013 0.026733733622997465 0.19255182806035936 4.366967750193826 0.012547395338899741 0.009095930123984693 6.24942443591588e-08 7.204159978786494 0.07134000448857125 ATNES(ph)EDEIPQLVPIGK ddPTM_A459_Selumetinib_30min_R2 33 ATNESEDEIPQLVPIGK 17 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 AT(0.015)NES(0.985)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.092)NES(0.908)EDEIPQLVPIGK;AT(0.029)NES(0.971)EDEIPQLVPIGK;AT(0.06)NES(0.94)EDEIPQLVPIGK;AT(0.023)NES(0.977)EDEIPQLVPIGK;AT(0.015)NES(0.985)EDEIPQLVPIGK;AT(0.028)NES(0.972)EDEIPQLVPIGK;AT(0.017)NES(0.983)EDEIPQLVPIGK;AT(0.17)NES(0.83)EDEIPQLVPIGK;AT(0.188)NES(0.812)EDEIPQLVPIGK;AT(0.07)NES(0.93)EDEIPQLVPIGK;AT(0.004)NES(0.996)EDEIPQLVPIGK;AT(0.017)NES(0.983)EDEIPQLVPIGK;AT(0.007)NES(0.993)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.002)NES(0.998)EDEIPQLVPIGK;AT(0.002)NES(0.998)EDEIPQLVPIGK;AT(0.002)NES(0.998)EDEIPQLVPIGK;AT(0.048)NES(0.952)EDEIPQLVPIGK;AT(0.002)NES(0.998)EDEIPQLVPIGK;AT(0.103)NES(0.897)EDEIPQLVPIGK;AT(0.003)NES(0.997)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;AT(0.001)NES(0.999)EDEIPQLVPIGK;AT(0.178)NES(0.822)EDEIPQLVPIGK;AT(0.004)NES(0.996)EDEIPQLVPIGK;AT(0.007)NES(0.993)EDEIPQLVPIGK;AT(0.003)NES(0.997)EDEIPQLVPIGK;AT(0.421)NES(0.579)EDEIPQLVPIGK;AT(0.22)NES(0.78)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK;ATNES(1)EDEIPQLVPIGK 234.51 6.0022e-17 806370500.0 4228338.199999999 3933200.4 4333981.8 4755755.3 4663334.7 3491626.9 3526343.5 3591167.6999999997 3251484.1 4233844.6 True False 3993344.090222929 4234864.223447393 4055138.1294706054 4108013.22400452 4077484.904244832 3972566.811641798 3690325.4600670803 3601617.4034571825 3901871.774056434 4111602.505548642 0.9712378774051913 1.0299789966886166 0.986267063510678 0.9991270358602812 0.991702115839805 0.9661845487935143 0.8975394520961001 0.875964395535991 0.9489905137451458 1.0 21.971269366202023 -7.013861214467017 3.4332209187137765 0.9206123483123247 0.9968633872234833 0.43417472296375426 0.0340772056766338 0.19106605795025483 4.733822510698417 0.012903618534765968 0.010421617053530272 9.685873339044694e-08 7.013861214467017 0.07625103891115859 ATNESEDEIPQLVPIGK ddPTM_A459_Selumetinib_30min_R2 1 ATNESEDEIPQLVPIGK 17 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 113.76 0.024711 1566500.0 13410.0 14086.0 17026.0 16045.0 16353.0 13246.0 14771.0 13271.0 11376.0 16950.0 False True 12664.725884483296 15166.350906371297 15930.565696507154 13859.643320831166 14298.589942325118 15070.516264783973 15457.880768181232 13309.616412867686 13651.517871997628 16460.6094586111 0.7693959276737442 0.9213723795893395 0.9677992626313929 0.8419884668110341 0.8686549534072715 0.9155503204591297 0.9390831370520545 0.8085737315093748 0.8293446185163004 1.0 14.006730132480202 -4.753782662925721 24.94254736801455 0.8943359536331723 0.7693956971008987 0.3008813621645461 0.05892697768306899 365.35687342187754 1190087.6869084314 0.014812712186544863 0.15327897265342752 1.762858025276656e-05 4.753782662925721 -0.12494025653227359 ATPAQT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 ATPAQTPR 8 0 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IS57;E5RFR3;E5RG53 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 ATPAQT(1)PR 97.472 0.047338 5699200.0 34641.0 27535.0 30473.0 35042.0 29064.0 35442.0 51355.0 71775.0 45432.0 64579.0 True False 32715.79189891023 29646.84596102042 28512.400356493756 30269.21914917828 25412.72048454334 40323.81378955715 53743.109258001954 71983.85336700901 54519.6694761424 62714.43647360743 0.5216628536984185 0.4727276146935788 0.45463854831084766 0.48265153689002205 0.4052132477541748 0.6429749840218514 0.8569495682324924 1.147803558711757 0.8693320476392434 1.0 15.93650996024064 -7.224819928885923 2.2101115765865345 1.0058582020802638 0.4692448983201705 0.9106732975621568 0.07458444573338509 0.07893289736450669 0.7548824200016736 0.03336756762516087 0.02231094915875008 5.959091735747974e-08 7.224819928885923 -0.5366133037600933 ATPATAPGT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 ATPATAPGTSPR 12 0 Q96P47;Q96P47-2;Q96P47-4;Q96P47-5;H0Y873 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 ATPAT(0.001)APGT(0.921)S(0.078)PR 125.84 0.0065943 8550900.0 42127.0 41061.0 46359.0 48970.0 47546.0 36636.0 39931.0 42325.0 33695.0 46951.0 True False 39785.749987742594 44210.24666807549 43376.31241186278 42300.201522038136 41572.84641336697 41682.276451504265 41787.8706217754 42448.158742719075 40434.94151696198 45595.402636651874 0.8725824904934782 0.969620709797989 0.9513308338897029 0.9277295313987448 0.9117771531629951 0.9141771766699557 0.9164930717857991 0.9309745344500393 0.8868205823114795 1.0 15.47660074499927 -11.372147102056683 7.054063583794341 1.0066952032953795 0.9225476842050382 0.44334535054474866 0.026716806038243297 0.002994829457128783 6.399362345266027e-05 0.027539289236283966 0.00621940258752916 4.244757632845889e-12 11.372147102056683 -0.08414751909034135 ATPATAPGTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ATPATAPGTSPR 12 0 Q96P47;Q96P47-2;Q96P47-4;Q96P47-5;H0Y873 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 ATPAT(0.003)APGT(0.235)S(0.762)PR 103.11 0.010997 16289000.0 6724.7 8352.7 8517.3 9473.9 7918.6 7368.4 7749.2 6251.3 3945.4 5123.1 True False 6881.372426011605 7374.762000935121 7360.697442179975 7819.461212128399 7202.364028142381 7294.280585971912 7164.671605083291 6085.495216915835 6695.055639385174 5780.699788219874 1.1904047395844224 1.2757559242159033 1.2733229041196499 1.3526841902537803 1.2459328960171272 1.2618334895779348 1.2394125049849027 1.0527263895137895 1.158173903621255 1.0 12.497028434807438 -7.693102187888442 4.905709033046848 1.0788483386340753 1.2685878608005587 0.7398708827194425 0.052310323616823105 0.10237170067900773 4.6500763718473035 0.02575808514642311 0.01411154699496797 2.0272056693886117e-08 7.693102187888442 0.1897395221664835 ATPATAPGTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 ATPATAPGTSPR 12 0 Q96P47;Q96P47-2;Q96P47-4;Q96P47-5;H0Y873 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 ATPATAPGT(0.028)S(0.972)PR;ATPATAPGT(0.323)S(0.677)PR;ATPATAPGT(0.395)S(0.605)PR 137.09 0.0013528 33054600.0 146473.0 137611.0 159278.0 168276.0 179934.0 135128.0 132743.0 137718.0 117244.0 140803.0 True False 138332.61703787645 148165.32121089473 149030.2268887739 145356.518507709 157329.08228963058 153740.65543014708 138915.81252526463 138118.73657955762 140696.07607106952 136737.65153987127 1.0116644207359384 1.083573686854577 1.0898989796187792 1.0630321412630417 1.1505907884029665 1.1243476372366825 1.015929489506833 1.0101002542030908 1.0289490457574813 1.0 17.06105102689461 -7.2813919129340565 23.59512059177228 1.0145863588765625 1.0889281132689759 0.5150540503466782 0.03488222868271822 354.86110108031056 419642.5058382183 0.015443594583339071 0.010432926221068938 5.231281459405848e-08 7.2813919129340565 0.07434175439241342 ATPELGSSENSAS(ph)SPPR ddPTM_A459_Selumetinib_30min_R2 2 ATPELGSSENSASSPPR 17 0 Q9BX63 Q9BX63 BRIP1 Fanconi anemia group J protein 1 ATPELGS(0.001)S(0.001)ENS(0.006)AS(0.654)S(0.338)PPR;ATPELGS(0.002)S(0.002)ENS(0.004)AS(0.701)S(0.292)PPR 161.94 1.8453e-05 49336000.0 71489.0 72724.0 89819.0 93532.0 104506.0 76558.0 72540.0 71915.0 73402.0 87140.0 True False 67515.92757314142 78301.69695548377 84040.14332753296 80792.78024830025 91377.02198450617 87103.16957567062 75913.25373528305 72124.26074383094 88084.45102323934 84624.04178308966 0.7978338797170648 0.9252890231382297 0.9931000878325646 0.9547260866526583 1.079799783360926 1.0292957856933318 0.8970648545701196 0.8522904274497021 1.0408915618686647 1.0 16.368779972371662 -4.790178464642074 2.516002273723596 0.9768666180071622 0.7605276074660868 0.42958013557815045 0.0638173119474383 0.541328422457721 4.435888527054284 0.017913037250299333 0.25348566800124683 1.62114378380944e-05 4.790178464642074 -0.2163390105410754 ATPT(ph)KAPAPVVLGSPVVLGPPVGQAR ddPTM_A459_Selumetinib_30min_R1 1 ATPTKAPAPVVLGSPVVLGPPVGQAR 26 1 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 AT(0.213)PT(0.787)KAPAPVVLGSPVVLGPPVGQAR 66.77 0.0019632 9549900.0 923.26 1270.0 770.7 632.21 781.7 719.99 823.18 758.88 538.61 758.76 True False 944.7701616487682 1121.3078095930184 666.0431731520683 521.8063915514934 710.9953730203441 712.7475542986149 761.0868698539797 738.7520372103551 913.9818314820426 856.1542369482755 1.1035046267088044 1.3097030432155206 0.7779476458893086 0.6094770883940838 0.830452437582574 0.8324990095700192 0.8889599992716741 0.8628726055758417 1.067543430889148 1.0 9.741726912611297 -5.264998376181061 24.988832195413355 0.844054201056737 1.2066038465093956 0.5490753587638588 0.12554327880728394 201.40605988102408 1414145.5004649893 0.033813184800963667 0.07517118864676887 5.43252362699052e-06 5.264998376181061 0.36254964545265855 ATPT(ph)KAPAPVVLGSPVVLGPPVGQAR ddPTM_A459_Selumetinib_30min_R2 1 ATPTKAPAPVVLGSPVVLGPPVGQAR 26 1 A0A0C4DFM2;Q6ZN55;Q6ZN55-2 A0A0C4DFM2 ZNF574 Zinc finger protein 574 1 AT(0.456)PT(0.544)KAPAPVVLGSPVVLGPPVGQAR 70.295 0.0011607999999999998 12066000.0 7709.9 6320.8 11580.0 15765.0 9730.3 10781.0 10430.0 10623.0 12624.0 10904.0 True False 7281.414623175075 6805.585035424651 10834.955407350699 13617.779803858108 8507.892724014313 12265.984889826064 10915.015666652915 10653.911171267679 15149.15274403111 10589.173188005632 0.6876282495240271 0.6426927687926896 1.0232107091820413 1.2860097348566346 0.8034520328415454 1.158351523017846 1.0307712861865708 1.0061136013277576 1.430626591431196 1.0 13.370302326374343 -5.312414670911589 4.640124298679346 1.0929031942067695 0.6621748740319153 0.5295102207984788 0.16191849566605296 0.14427146536021845 6.838116081774751 0.04125622221599123 0.09385969300627543 4.870632127213631e-06 5.312414670911589 -0.4307283201748542 ATPVQLPS(ph)PPCTSSPVVPSHPPVQQVK ddPTM_A459_Selumetinib_30min_R2 2 ATPVQLPSPPCTSSPVVPSHPPVQQVK 27 0 Q14686 Q14686 NCOA6 Nuclear receptor coactivator 6 1 AT(0.009)PVQLPS(0.988)PPCT(0.002)S(0.001)SPVVPSHPPVQQVK;ATPVQLPS(0.836)PPCT(0.124)S(0.029)S(0.01)PVVPSHPPVQQVK 121.5 5.2171e-12 14179200.0 103153.0 90513.0 109759.0 115443.0 117251.0 81514.0 86127.0 98483.0 87687.0 100507.0 True False 97420.16921417654 97455.05605483333 102697.22543656356 99719.46424971694 102520.88114276054 92741.81358958184 90132.07615741287 98769.56922526161 105226.8501794879 97605.10176145297 0.9981052983508136 0.9984627268051383 1.0521706712376138 1.021662417743608 1.050363959389354 0.9501738322679381 0.9234361168711838 1.0119303954690257 1.0780876028044364 1.0 16.574668938132547 -6.748179054468975 24.999855084617977 0.9891406387456618 1.0241439397326706 0.1226636711031791 0.041474140881962655 513.7064844480722 968493.6382821907 0.014834480678097582 0.014753459596160777 1.785751179006933e-07 6.748179054468975 0.03500330098700877 ATQCLVKS(ph)PEVK ddPTM_A459_Selumetinib_30min_R1 1 ATQCLVKSPEVK 12 1 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 ATQCLVKS(1)PEVK 146.47 0.0031113000000000004 21434000.0 1807.3 2055.2 3515.3 3608.5 1961.1 2080.4 1540.2 2042.7 1347.1 1528.4 True False 1849.406573606374 1814.576228563442 3037.9415681607184 2978.3432149342225 1783.7188512603252 2059.473064852065 1424.0214739778658 1988.5209603752799 2285.9303117087684 1724.5850278767248 1.0723777278081366 1.0521813649266762 1.7615493113151819 1.7269912279135928 1.0342887259414544 1.194184706211701 0.8257183327928418 1.1530431542847777 1.3254958582837524 1.0 10.752033544961018 -6.305517262320063 24.976791586312668 1.0885568524891702 1.4037881876642004 0.2777459163998972 0.24844332590896315 663.2846572646089 375849.4088862445 0.0840064363153171 0.09525474563429209 4.948604408359388e-07 6.305517262320063 0.3152313351750302 ATQCLVKS(ph)PEVK ddPTM_A459_Selumetinib_30min_R2 2 ATQCLVKSPEVK 12 1 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 ATQCLVKS(1)PEVK;ATQCLVKS(1)PEVK 107.07 0.040985 58367200.0 321828.0 393274.0 285413.0 326625.0 278744.0 221037.0 229017.0 213849.0 140429.0 308262.0 True False 303942.088139559 423436.85122478055 267049.8383141778 282138.11154044775 243725.6867170225 251482.8403758912 239666.74428857656 214471.26518539246 168518.7239140956 299361.67509913736 1.0153005993132047 1.4144657998875578 0.8920642170569795 0.9424657028893701 0.8141512658101933 0.8400635795901713 0.8005926082863076 0.7164285979972808 0.562926847126602 1.0 18.19153001085148 -5.638240350567705 1.4720397335943747 0.778593304206479 1.2152726181086881 0.5087021852444684 0.1500042005599163 0.32349128296472657 1.3713632780132305 0.04662205281701209 0.12774519554159525 2.3001684882883034e-06 5.638240350567705 0.43667931390220915 ATRPASTSQPDPS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 3 ATRPASTSQPDPSPDR 16 1 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 ATRPASTSQPDPS(1)PDR;ATRPASTSQPDPS(1)PDR;ATRPASTSQPDPS(1)PDR 185.99 3.7535e-06 49305500.0 4650.460000000001 6107.32 3926.0299999999997 4276.110000000001 6053.97 4097.25 6130.92 4948.36 2626.8900000000003 5319.2300000000005 True False 4758.806669780058 5392.27213518396 3392.896690139111 3529.367661026014 5506.389482415212 4056.0353850053507 5668.459768367992 4817.113418261429 4457.6404695454285 6002.004984187852 0.7928694964960922 0.8984118056199188 0.565293880807767 0.5880314445462899 0.9174250099627829 0.675780076106382 0.9444277009601663 0.8025840416580804 0.7426918973391363 1.0 12.551228801642292 -6.894128221078027 1.471344646879165 0.8498155707166902 0.7292222436079265 0.15890704734196104 0.1305386053905208 0.8812153236937416 3.9350762682969083 0.06483621199166331 0.05247265026468335 1.2760620087163057e-07 6.894128221078027 -0.12059332710876369 ATRPASTSQPDPS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 4 ATRPASTSQPDPSPDR 16 1 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 ATRPASTSQPDPS(1)PDR;ATRPASTSQPDPS(1)PDR;ATRPASTSQPDPS(1)PDR;ATRPASTSQPDPS(1)PDR 106.6 0.016446000000000002 93646600.0 48288.7 35141.7 41200.6 47935.299999999996 49331.6 31453.399999999998 40674.899999999994 43326.7 32680.0 33735.8 True False 45605.00736898203 37836.95539162489 38549.79825182153 41406.42944699522 43134.12337790043 35785.82034446298 42566.36344578531 43452.7735238787 39216.91315549248 32761.759797865005 1.392019465692865 1.1549121788656367 1.1766705601184988 1.2638646306690022 1.31659970783106 1.0923045820876522 1.2992697495010401 1.3263259907885168 1.1970331690805005 1.0 14.999725232971118 -8.55198636287733 20.573737423739402 0.9999999956568881 1.2466525460742137 0.44064883599095905 0.0851903150797269 754.7537126232239 533472.768163138 0.08079776910130354 0.02086189427515481 2.8055217317335345e-09 8.55198636287733 0.2466525504173256 ATRPASTSQPDPS(ph)PDRSANTSPESSSR ddPTM_A459_Selumetinib_30min_R1 1 ATRPASTSQPDPSPDRSANTSPESSSR 27 2 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 ATRPASTSQPDPS(0.428)PDRS(0.033)ANT(0.045)S(0.205)PES(0.085)S(0.085)S(0.118)R 79.426 0.00012448 3062300.0 0.0 0.0 222.03 179.48 214.58 0.0 0.0 0.0 119.48 0.0 True False 0.0 0.0 191.87954552348987 148.13718725686405 195.171276887176 0.0 0.0 0.0 202.74883352606608 0.0 0.0 ATRPASTSQPDPSPDRS(ph)ANTSPESSSR ddPTM_A459_Selumetinib_30min_R1 1 ATRPASTSQPDPSPDRSANTSPESSSR 27 2 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 ATRPASTSQPDPS(0.048)PDRS(0.695)ANT(0.138)S(0.029)PES(0.082)S(0.006)S(0.002)R 128.51 7.441000000000001e-12 2683000.0 0.0 0.0 136.98 163.46 268.18 115.4 117.51 122.91 67.816 125.0 True False 0.0 0.0 118.37886837728078 134.91477952422002 243.92316635102446 114.23918077481659 108.64612609215622 119.65002753205346 115.07879891533057 141.04496760310823 0.0 0.0 0.839298773922878 0.9565373498745579 1.7293999955915413 0.8099486476985024 0.770294239762454 0.8483112128377468 0.8159014878088748 1.0 7.140011382152956 -5.311974211569118 3.7096263627023562 0.9919064178147474 7.772504879475088e-14 0.6905912289276088 0.2613818082889345 0.13197741862812362 3.730096436684134 0.07541117832874403 0.18526471176400558 4.875574404322117e-06 5.311974211569118 -0.9919064178146697 ATS(ph)DEEDSVLSIAR ddPTM_A459_Selumetinib_30min_R2 1 ATSDEEDSVLSIAR 14 0 A6QL64 A6QL64 ANKRD36 Ankyrin repeat domain-containing protein 36A 1 AT(0.056)S(0.94)DEEDS(0.004)VLSIAR 85.976 0.04295 0.0 9283.5 9100.1 8341.5 10110.0 9342.8 7327.9 11233.0 11463.0 9632.0 8959.0 True False 8767.560234794979 9798.048408566625 7804.816971538501 8733.000559277221 8169.0739383082655 8337.25170894689 11755.356757767227 11496.355432198186 11558.669140566195 8700.33039172253 1.0077272747177983 1.1261696932668743 0.8970713317926389 1.0037550490709841 0.9389383587179977 0.9582684028734044 1.3511391209868584 1.3213699841945987 1.3285322074162933 1.0 13.086854472456688 -7.256185464878275 24.996455282154397 1.2770411641864536 0.989169299061572 0.5773352743740117 0.10869452644707539 279.1779738804439 1328244.4702092279 0.04078459102219895 0.030630048317757053 5.543889113546807e-08 7.256185464878275 -0.2878718651248816 ATS(ph)FEESER ddPTM_A459_Selumetinib_30min_R1 1 ATSFEESER 9 0 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 AT(0.093)S(0.607)FEES(0.3)ER 136.49 0.0026355000000000003 20389000.0 2700.1 3571.3 3888.6 3843.8 3374.7 3175.2 3664.5 3059.3 1289.9 2049.1 True False 2763.007076519985 3153.1705357476717 3360.5494785508376 3172.5524870622585 3069.458980851678 3143.260370850931 3388.0838146941246 2978.157425993093 2188.8660894314753 2312.1219449242317 1.1950092349521506 1.363756155971696 1.453448199792491 1.3721389107641653 1.3275506456698867 1.359469978541264 1.46535688661748 1.288062436555736 0.9466914555422398 1.0 11.175001774498073 -8.188007248638177 4.151795416014602 0.9705178365151469 1.365185155957159 0.8202348382556155 0.07160545008665344 0.08438436199880929 2.6870240028381693 0.056104427484533925 0.01871411242894052 6.486236075366792e-09 8.188007248638177 0.39466731944201217 ATS(ph)FSSAGEVPKPRPPSTR ddPTM_A459_Selumetinib_30min_R1 2 ATSFSSAGEVPKPRPPSTR 19 2 O15231-3;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6 O15231-3 ZNF185 Zinc finger protein 185 1 AT(0.205)S(0.782)FS(0.01)S(0.003)AGEVPKPRPPSTR;AT(0.162)S(0.808)FS(0.023)S(0.007)AGEVPKPRPPSTR 86.189 0.0014212 168091000.0 4373.4 5006.4 5378.4 5264.0 4919.3 4517.8 5115.9 4368.3 3144.3 3901.4 True False 4475.291710844966 4420.248360587785 4648.042821436461 4344.741217518011 4474.350183572954 4472.355033834198 4730.00354416528 4252.438493761851 5335.64744941421 4402.18269285413 1.0166074475076896 1.0041037978189729 1.0558495968332764 0.9869515921205719 1.0163935701341904 1.015940351838186 1.0744677979501593 0.9659841016286415 1.2120458921605712 1.0 12.10400330372287 -8.236793967675338 24.996569721298766 1.1060230601566992 1.0187533850455772 0.2898015947421808 0.05566921588410875 773.8883197444711 784917.2547936192 0.033932310418223366 0.012815680928157687 5.7970364664695885e-09 8.236793967675338 -0.08726967511112194 ATS(ph)NVFAMFDQSQIQEFK ddPTM_A459_Selumetinib_30min_R2 1 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;J3KTJ1;P24844;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 1 AT(0.305)S(0.695)NVFAMFDQSQIQEFK 77.23100000000002 0.026078 1708500.0 15894.0 16515.0 14034.0 18957.0 15921.0 15621.0 12527.0 13775.0 13147.0 14883.0 True False 15010.675108723151 17781.64739590529 13131.06771906388 16375.023897350973 13920.861644454124 17772.650956680543 13109.530321779579 13815.08296942598 15776.767357872075 14453.289119322058 1.0385646467596046 1.2302837955502928 0.9085176121959291 1.1329617613100826 0.9631621930155572 1.22966134628283 0.9070274740615228 0.9558435353622806 1.0915693464389853 1.0 13.819110222182967 -5.181681375613351 0.307748588876184 0.9975760148991537 1.1673301415444426 0.05426568946180588 0.11202913268108923 17.309945398999997 1.620622497426467 0.1252241993391688 1.083551500793784 6.581405114861285e-06 5.181681375613351 0.16975412664528888 ATS(ph)PEAGGGGGALK ddPTM_A459_Selumetinib_30min_R1 2 ATSPEAGGGGGALK 14 0 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 AT(0.01)S(0.99)PEAGGGGGALK;AT(0.007)S(0.993)PEAGGGGGALK 188.96 7.031e-05 43187000.0 13553.9 15776.2 16160.7 16565.3 16281.8 13559.4 14355.0 13971.7 7373.1 11124.9 True False 13869.679498701607 13929.115169843597 13966.16570437086 13672.481324192844 14809.11406478526 13423.004746950151 13272.190792723202 13601.125129522337 12511.612190082338 12552.889280702553 1.104899373248145 1.1096341932416072 1.1125857475570127 1.0891899879346048 1.179737487810968 1.0693159516339572 1.0573016694352928 1.0835055440528125 0.9967117458222411 1.0 13.615731845015759 -7.9040870127805825 0.9311698792610681 0.996081646407933 1.1145461950466866 0.6673082238235488 0.029731371766946575 0.33865486878701645 0.5442697850391464 0.027104463169543132 0.010685458357071569 1.2471336205873354e-08 7.9040870127805825 0.11846454863875366 ATS(ph)PEAGGGGGALK ddPTM_A459_Selumetinib_30min_R2 1 ATSPEAGGGGGALK 14 0 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 AT(0.094)S(0.906)PEAGGGGGALK 137.62 0.00058544 4266400.0 46282.0 49952.0 50809.0 54952.0 44258.0 37492.0 43152.0 45595.0 35980.0 45654.0 True False 43709.83172152545 53783.1577790046 47540.004256656415 47467.44280251259 38697.914368459926 42656.18268150997 45158.65350406585 45727.67390134142 43177.005365196404 44335.85039666261 0.9858800796751092 1.213085060911635 1.0722700440236734 1.070633412415288 0.8728357305033878 0.9621149092636085 1.018558414917991 1.0313927327935855 0.9738621223885797 1.0 15.436186127375203 -6.025009748084254 21.368935316658526 0.9787193299621437 1.0974746600807883 0.40093460202676023 0.06540606297344163 115.19503576578927 98425.84404094354 0.019256197410087366 0.02504120234370155 9.440396863282675e-07 6.025009748084254 0.11875533011864459 ATS(ph)PESTSR ddPTM_A459_Selumetinib_30min_R2 1 ATSPESTSR 9 0 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 AT(0.025)S(0.974)PES(0.001)TSR 115.7 0.0080838 13940000.0 80626.0 70195.0 69363.0 74381.0 74373.0 71483.0 152670.0 436780.0 84268.0 196630.0 True False 76145.12969145043 75578.73078750072 64900.2600967242 64250.179485618144 65029.5988369441 81329.13439193359 159769.45750986593 438050.9574871781 101123.95464464626 190952.7809939058 0.3987641829310702 0.39579801034640494 0.33987596178971324 0.33647155674401347 0.34055329541924556 0.4259122803481411 0.836696154296726 2.294027639750156 0.5295757103839908 1.0 17.5428564056405 -7.525677927935742 24.99993489520833 1.3601534715955346 0.39114298544406445 0.4886904845833282 0.4124507422487661 64.56962683008743 576660.2731413069 0.17888611665074042 0.10402410368311552 2.9807261114981325e-08 7.525677927935742 -0.9690104861514701 ATS(ph)PLCTSTASMVSSSPSTPSNIPQKPSQPAAK ddPTM_A459_Selumetinib_30min_R2 1 ATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAK 33 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 AT(0.265)S(0.688)PLCT(0.041)S(0.002)T(0.002)AS(0.001)MVSSSPSTPSNIPQKPSQPAAK 116.24 7.717699999999998e-19 11529000.0 70972.0 70758.0 81925.0 79510.0 79415.0 63350.0 65984.0 65677.0 59477.0 79270.0 True False 67027.66036342642 76184.9110771704 76654.03469319573 68680.60083759968 69438.17772089221 72075.88746595684 69052.3867448155 65868.10919658738 71374.06192623089 76981.26913180541 0.8707009006134119 0.9896551711394689 0.9957491680469778 0.8921728832504237 0.9020139379879786 0.9362782437705762 0.8970024464858553 0.855638130410784 0.927161408628195 1.0 16.232219835513334 -5.7801615545429454 24.96436101851045 0.909238910837416 0.9557971103804969 0.09675029907514399 0.04758155912466324 407.4581895661009 543308.0589447918 0.013076902567190747 0.019434243696737175 1.6589696674001618e-06 5.7801615545429454 0.046558199543080825 ATS(ph)PLVSLYPALECR ddPTM_A459_Selumetinib_30min_R1 3 ATSPLVSLYPALECR 15 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3;Q96G74-4 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 AT(0.141)S(0.857)PLVS(0.002)LYPALECR;AT(0.082)S(0.918)PLVSLYPALECR;AT(0.065)S(0.935)PLVSLYPALECR 283.66 1.7115e-55 397429000.0 8108.900000000001 9791.5 10702.5 10847.0 9649.1 8115.8 8954.9 9103.0 5076.42 7045.0 True False 8297.821592827264 8645.106628055144 9249.159284624382 8952.775073407653 8776.340608686965 8034.162420556817 8279.424683368648 8861.558869288769 8614.313972952728 7949.294374111182 1.0438437932115265 1.087531323058062 1.1635195338527815 1.126235191712682 1.1040402073005702 1.010676173563534 1.0415295111390788 1.1147604368695414 1.0836576892921899 1.0 12.956611088687868 -6.599745595795703 12.702053524805468 1.0567754760208519 1.109043803167433 0.2915602023077841 0.04200353073867318 1.098177191728603 177.9172477934198 0.014737283788215701 0.014735924882491301 2.513358293808615e-07 6.599745595795703 0.05226832714658114 ATS(ph)PSSSVSGDFDDGHHSVSTPGPSR ddPTM_A459_Selumetinib_30min_R1 1 ATSPSSSVSGDFDDGHHSVSTPGPSR 26 0 Q86U86-8;Q86U86;E7EVG2;Q86U86-6;Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;C9J409;C9JCJ2;C9J053;C9JQF1;C9JPI5 Q86U86-8 PBRM1 Protein polybromo-1 1 AT(0.123)S(0.371)PS(0.371)S(0.103)S(0.03)VS(0.003)GDFDDGHHSVSTPGPSR 70.593 0.00041148 6397300.0 616.29 1067.0 691.01 955.62 1667.3 841.96 1165.7 788.22 321.55 513.94 True False 630.6483579084115 942.0751439651577 597.1746374462314 788.7389062090732 1516.4930093857236 833.4906468385143 1077.7703104895452 767.3138451006031 545.6468649171959 579.9092051995317 1.087494994481803 1.6245217967199093 1.0297726473246085 1.360107580871541 2.6150524871629477 1.4372778348150756 1.8585156104199319 1.3231620367822758 0.9409177506148622 1.0 9.179683228873296 -6.0167546271356604 24.973132465301745 1.5963132583535766 1.269980722388243 0.05776695001422272 0.4699272978659467 1854.6700071136104 2764427.9337876425 0.1397655311448113 0.18521895687433051 9.62155735041407e-07 6.0167546271356604 -0.3263325359653335 ATS(ph)PSSSVSGDFDDGHHSVSTPGPSR ddPTM_A459_Selumetinib_30min_R2 1 ATSPSSSVSGDFDDGHHSVSTPGPSR 26 0 Q86U86-8;Q86U86;E7EVG2;Q86U86-6;Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;C9J409;C9JCJ2;C9J053;C9JQF1;C9JPI5 Q86U86-8 PBRM1 Protein polybromo-1 1 AT(0.167)S(0.492)PS(0.11)S(0.11)S(0.11)VS(0.01)GDFDDGHHSVSTPGPSR 49.152 0.020478 12401000.0 15899.0 11101.0 15441.0 28071.0 27137.0 19074.0 14874.0 16506.0 17685.0 26541.0 True False 15015.397228739736 11952.41100465908 14447.542870889654 24247.681374824024 23727.80745214192 21701.270363467436 15565.670472271868 16554.029727284593 21222.494160186183 25774.69236820041 0.582563586569321 0.4637266212110216 0.5605321167174956 0.9407554134279276 0.9205854763727912 0.8419604026095548 0.6039129487914298 0.6422590613616079 0.8233849644843672 1.0 14.653667588073182 -5.65399142682065 6.789741471268913 0.804746529996539 0.5215072160803511 0.5427329394258522 0.12081687104166929 0.18492464963250324 10.445267577533087 0.03576185283496087 0.062257469882411307 2.218240208483326e-06 5.65399142682065 -0.28323931391618784 ATS(ph)PVKSTTSITDAK ddPTM_A459_Selumetinib_30min_R1 2 ATSPVKSTTSITDAK 15 1 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 AT(0.004)S(0.975)PVKS(0.005)T(0.005)T(0.002)S(0.001)IT(0.007)DAK;AT(0.003)S(0.997)PVKSTTSITDAK 211.49 4.543e-06 53868000.0 5938.3 3923.0 24253.7 23909.9 12282.099999999999 9423.7 5404.700000000001 6623.5 5811.9 3529.3 True False 6076.650836079634 3463.6933362467807 20960.180756037764 19734.484809409932 11171.186223580873 9328.906134034998 4997.019127651065 6447.823263839852 9862.36981561888 3982.3200332931992 1.5259072061705994 0.8697677000566081 5.263308970852511 4.955524579748656 2.8051954966418924 2.3425807207966693 1.2548009918526701 1.6191122787557064 2.4765387344982277 1.0 11.959393450444807 -6.8891409489734325 2.880735477970111 1.652151934582772 3.197484444857103 0.2244111884706147 1.3029299346169327 0.4587195115639547 7.6750862472642405 0.5593192707334093 0.48322612533930814 1.290800280260554e-07 6.8891409489734325 1.545332510274331 ATS(ph)TATSGFAGAIGQK ddPTM_A459_Selumetinib_30min_R1 2 ATSTATSGFAGAIGQK 16 0 E7ER27;A0A2R8YD50;P51659-3;P51659;P51659-2;A0A2R8Y7L2;E7ET17;E7EPL9 E7ER27 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 1 ATS(0.458)T(0.458)AT(0.032)S(0.051)GFAGAIGQK;ATS(0.925)T(0.051)AT(0.019)S(0.005)GFAGAIGQK 158.89 6.5544e-05 19434300.0 4073.1 5004.2 4952.6 5483.799999999999 5093.4 4409.2 4232.4 4019.5 2904.45 3770.5 True False 4167.995305127051 4418.305937610535 4280.064122684486 4526.1572736750095 4632.702869312807 4364.847451233288 3913.146660475209 3912.8898028239264 4928.639517365102 4254.480402780155 0.979671995293106 1.0385065905400166 1.0060133594428156 1.0638566511476522 1.0888998022615164 1.0259413695691282 0.919770756945573 0.9197103834975922 1.1584586249696691 1.0 12.054767231824602 -7.019654830751449 24.715002985013793 0.9899458419679364 1.0377031518683217 0.0517494085867628 0.06784748517103946 1681.910362905225 2114914.9564783648 0.025755272242505386 0.020233620738248633 9.557518982284361e-08 7.019654830751449 0.04775730990038529 ATS(ph)TATSGFAGAIGQK ddPTM_A459_Selumetinib_30min_R2 1 ATSTATSGFAGAIGQK 16 0 E7ER27;A0A2R8YD50;P51659-3;P51659;P51659-2;A0A2R8Y7L2;E7ET17;E7EPL9 E7ER27 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 1 AT(0.004)S(0.938)T(0.059)ATSGFAGAIGQK 321.34 1.601099999999999e-117 7098600.0 45228.0 36026.0 46897.0 49078.0 51812.0 38688.0 44255.0 41554.0 38114.0 39310.0 True False 42714.40882202912 38789.07835815224 43879.698077592904 42393.49173572778 45302.913354843105 44016.92082530293 46312.94518961889 41674.915260365 45737.86499413832 38175.01816035412 1.1189099804119882 1.0160853937310197 1.1494348972743453 1.1105035119473674 1.1867162227545844 1.1530294665587297 1.213174149520543 1.091680299543266 1.198109842463374 1.0 15.22034122288059 -5.2865193271531945 24.36938515536185 1.145108894823406 1.0674976850519513 0.15890898340019555 0.06296807709069036 719.7359262712048 699343.9378873152 0.015189879324301023 0.03164516492515724 5.169882502311319e-06 5.2865193271531945 -0.07761120977145475 ATS(ph)TSTSGAGDVGK ddPTM_A459_Selumetinib_30min_R1 1 ATSTSTSGAGDVGK 14 0 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 ATS(0.395)T(0.395)S(0.045)T(0.023)S(0.142)GAGDVGK 85.67200000000003 0.024303 12070000.0 1266.1 1669.8 1525.8 1810.1 1757.8 1446.7 1412.5 1601.6 963.68 1415.9 True False 1295.597666598256 1474.2990397310402 1318.6047406194693 1494.0000147852115 1598.8073003647958 1432.1475114985028 1305.9539877897264 1559.1203652700087 1635.2945755975834 1597.644557033928 0.8109423719400825 0.9227953947830034 0.8253429931044838 0.9351266576833989 1.0007277859932915 0.8964118490519097 0.8174246155316716 0.9758868819761508 1.023565954265543 1.0 10.641730758733054 -1.5228787454705093 0.11432229033894904 1.0455096906129653 0.4274326250329016 0.3649431816065122 0.061173890318574724 131.3774152730953 1.0456004348991381 0.5333552475365849 12.853281104194714 0.029999999986863403 1.5228787454705093 -0.6180770655800637 ATS(ph)VDYSSFADR ddPTM_A459_Selumetinib_30min_R1 1 ATSVDYSSFADR 12 0 Q86YS7-3;Q86YS7-2;Q86YS7-4 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 AT(0.004)S(0.995)VDYS(0.001)SFADR 176.99 0.00010361 7742600.0 1973.4 2499.0 2315.3 2253.1 1927.7 1948.0 2081.4 2110.9 1051.3 1716.9 True False 2019.376380432034 2206.4159182464196 2000.8949770325464 1859.6383809251188 1753.3398753630765 1928.4048886424837 1924.3983222552463 2054.9120748304586 1783.9793160859817 1937.280839022211 1.0423766857939185 1.1389241424387633 1.0328368178371303 0.9599219397966687 0.9050519883570554 0.9954183460647826 0.9933502068943877 1.0607197642380124 0.9208676822439414 1.0 10.91981739487363 -5.527587894384973 4.710527868771157 0.9781388110546737 1.0907507312288303 0.49461846972554535 0.046380372912410255 0.14964767963013878 8.892144723007162 0.012792623832369204 0.024695016837083188 2.967646077706779e-06 5.527587894384973 0.11261192017415655 ATSACAPISS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ATSACAPISSPK 12 0 E7EUN2;A0A087X1U1;F5GXM9;Q9UPQ3-2;Q9UPQ3;H7C211 E7EUN2 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 1 ATSACAPIS(0.051)S(0.949)PK;ATSACAPIS(0.083)S(0.917)PK 148.96 0.00058891 17147100.0 5383.6 6675.8 6831.6 7677.2 5369.6 5744.4 6281.5 6566.7 4012.8 5973.5 True False 5509.027405337947 5894.194232504776 5903.906243292677 6336.521138892342 4883.920628079876 5686.616551497885 5807.681397735335 6392.5297843522485 6809.428516683943 6740.256911817333 0.8173319618840141 0.8744761972159844 0.8759170934481255 0.9401008332164397 0.7245896843363876 0.8436794955883422 0.8616409543014654 0.9484104045269501 1.0102624582076887 1.0 12.718587866920995 -7.885878630797645 2.4736716167773496 1.0036788026058459 0.8474026433525023 0.6160717733056957 0.051287870752214616 0.20851895532882786 2.4822426370176753 0.03826007224104346 0.014871439881883271 1.3005329779910209e-08 7.885878630797645 -0.1562761592533436 ATSACAPISS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ATSACAPISSPK 12 0 E7EUN2;A0A087X1U1;F5GXM9;Q9UPQ3-2;Q9UPQ3;H7C211 E7EUN2 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 1 ATSACAPIS(0.092)S(0.908)PK;ATSACAPIS(0.116)S(0.884)PK 153.49 0.0004675 25823000.0 189283.0 172214.0 168587.0 175449.0 155801.0 131024.0 154029.0 152882.0 109045.0 159891.0 True False 178763.40861988443 185422.2600447131 157740.29596364702 151552.54353359356 136227.88550138782 149071.36668254997 161191.65370267324 153326.86130902258 130857.04697186894 155274.53138329132 1.1512732128529912 1.194157589096198 1.015880032342645 0.9760296307672626 0.877335673067418 0.9600503402233493 1.038107487858235 0.9874566031085873 0.8427463654606149 1.0 17.244461688191343 -5.405781100049196 2.903783930468157 0.9552264602317514 1.1752908162228972 0.7060270948726368 0.0553469657792743 0.14509509392383274 2.3176858268727294 0.015713281421192923 0.03869059333073093 3.9284289237393585e-06 5.405781100049196 0.22006435599114582 ATSAGS(ph)SPSCSLAGR ddPTM_A459_Selumetinib_30min_R1 3 ATSAGSSPSCSLAGR 15 0 Q9BXB5;Q9BXB5-2 Q9BXB5 OSBPL10 Oxysterol-binding protein-related protein 10 1 ATSAGS(0.499)S(0.499)PS(0.002)CSLAGR;ATSAGS(0.499)S(0.499)PS(0.002)CS(0.001)LAGR;ATSAGS(0.499)S(0.499)PS(0.002)CSLAGR 252.46 3.1261e-28 51606000.0 11034.4 12794.5 12280.5 14075.2 13133.2 10717.199999999999 10781.1 10781.4 6198.5 8997.4 True False 11291.480050795199 11296.51399199832 10612.875551957926 11617.230544226728 11945.304378854782 10609.394698439035 9967.87294708659 10495.442249077214 10518.401779472046 10152.303932097653 1.112208630308625 1.1127044725565314 1.0453662166677382 1.1442949917503498 1.1766102018565812 1.0450233532603608 0.9818335831704206 1.0337990587431776 1.0360605681058201 1.0 13.309519544814956 -6.954056673765639 8.212168496112772 1.0153803222768047 1.11514197445052 0.68395144905059 0.03412330974174567 0.16283531514076843 25.923706746503374 0.012780204082245802 0.011242331074995256 1.1115866600169874e-07 6.954056673765639 0.09976165217371524 ATSAGSS(ph)PSCSLAGR ddPTM_A459_Selumetinib_30min_R2 3 ATSAGSSPSCSLAGR 15 0 Q9BXB5;Q9BXB5-2 Q9BXB5 OSBPL10 Oxysterol-binding protein-related protein 10 1 ATS(0.001)AGS(0.223)S(0.766)PS(0.011)CSLAGR;ATSAGS(0.221)S(0.72)PS(0.046)CS(0.013)LAGR;ATSAGS(0.068)S(0.917)PS(0.011)CS(0.004)LAGR 225.21 3.097e-10 59364000.0 116676.0 101671.0 116692.0 119370.0 130527.0 93242.0 95112.0 99304.0 83166.5 97281.0 True False 110191.61501103459 109468.83877620874 109184.16376464325 103111.60007526453 114129.03133381456 106085.23913339773 99534.89646085248 99592.95819933777 99802.12386616481 94472.2447636072 1.166391412491162 1.1587407396757292 1.155727420660416 1.091448608353439 1.2080694347783678 1.1229249331255873 1.0535887731884988 1.054203363628586 1.0564174072066803 1.0 16.52760291815939 -7.200148569743424 3.2548585222461663 1.0437491672681116 1.1535222666395961 0.7588415053973724 0.030642894538563194 0.12850042104724035 2.7045806785425137 0.012678202391767465 0.009176584382965864 6.307415343735801e-08 7.200148569743424 0.1097730993714845 ATSCFPRPMT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 ATSCFPRPMTPR 12 1 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 ATSCFPRPMT(1)PR 96.707 0.023357 10772000.0 36492.0 31388.0 39759.0 42288.0 47862.0 33959.0 37639.0 34430.0 32032.0 33768.0 True False 34463.92072905031 33795.35867167275 37200.94922632609 36528.301449131104 41849.14766829112 38636.54400089075 39389.28808026356 34530.18559980667 38439.29504885966 32793.030100199394 1.0509526147399462 1.0305652929421507 1.1344163412974726 1.1139044283958681 1.2761598284885747 1.1781937772397504 1.2011481695930277 1.0529733145823785 1.1721788115159855 1.0 15.001101593526823 -5.359437577167146 2.8242760219912175 1.153086796165236 1.038262711933587 0.2184102800785942 0.07342232076193003 0.3662973664881622 5.572853866186795 0.01994085318831747 0.052492479665799154 4.370814979774029e-06 5.359437577167146 -0.11482408423164903 ATSDTLES(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 ATSDTLESPPK 11 0 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 ATSDT(0.005)LES(0.995)PPK;ATSDT(0.005)LES(0.995)PPK 157.03 0.00055491 18176100.0 146436.0 138609.0 135976.0 135076.0 127485.0 119351.0 157336.0 152884.0 108684.0 131615.0 True False 138297.67334975366 149239.8646018188 127227.45219947473 116678.41578090299 111469.19456963969 135790.5168894936 164652.43575536943 153328.8671286915 130423.83688468627 127814.93297316211 1.082014989428447 1.16762463610692 0.9954036609023553 0.9128699837084177 0.8721140165448852 1.0623994687538283 1.2882096944802393 1.1996162229407628 1.0204115735997137 1.0 16.96369687463229 -7.006997304138841 24.983591144804784 1.1482098540987213 1.005024679061469 0.20526632928401956 0.10915937037794711 472.66345415430635 1687628.9504533398 0.042331714572205026 0.03590745289545156 9.840172139795515e-08 7.006997304138841 -0.14318517503725237 ATSEEDVS(ph)IKSPICEK ddPTM_A459_Selumetinib_30min_R1 3 ATSEEDVSIKSPICEK 16 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 AT(0.002)S(0.014)EEDVS(0.809)IKS(0.175)PICEK;ATS(0.001)EEDVS(0.863)IKS(0.136)PICEK;AT(0.01)S(0.192)EEDVS(0.399)IKS(0.399)PICEK 69.612 0.024611 115104000.0 14965.500000000002 26878.4 18770.5 22104.199999999997 17194.7 22371.199999999997 22787.1 21515.199999999997 11062.3 18772.5 True False 15314.16703220616 23731.464432570832 16221.56919897612 18244.11641722296 15639.442420970856 22146.16603942439 21068.250701000543 20944.54700478103 18771.915141575162 21182.133234634784 0.722975673062336 1.1203529016505123 0.7658137648030806 0.861297406410045 0.7383317934852234 1.0455116014100658 0.9946236513398927 0.9887836495398264 0.8862145721414552 1.0 14.370560268787719 -6.776720753530028 24.99065901860143 0.983050477944605 0.8540987912532898 0.28532685628053567 0.11093481038991201 350.62193868038804 573392.083785052 0.03821636091441651 0.03382853467853328 1.6721654523083726e-07 6.776720753530028 -0.12895168669131518 ATSEEDVS(ph)IKSPICEK ddPTM_A459_Selumetinib_30min_R2 3 ATSEEDVSIKSPICEK 16 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 AT(0.024)S(0.076)EEDVS(0.689)IKS(0.21)PICEK;AT(0.003)S(0.05)EEDVS(0.783)IKS(0.164)PICEK;ATSEEDVS(0.941)IKS(0.059)PICEK 129.32 0.0041784 114119400.0 296862.0 238177.0 313990.0 324331.0 315170.0 232097.0 294760.0 309912.0 210725.0 276887.0 True False 280363.598472743 256444.41004023788 293788.2252464629 280156.5582978176 275575.5269444512 264066.25498320727 308466.92405585956 310813.7926113061 252875.88814844404 268892.55287117715 1.0426603320883396 0.9537058847557485 1.092585949701675 1.0418903584586698 1.024853697143765 0.9820512028450186 1.1471754080286558 1.155903312652221 0.9404347031864193 1.0 18.03667027395924 -7.235709131873599 24.990338887934385 1.0738703351119652 1.0239217401991754 0.05517726084000052 0.06887524940023233 1767.4963190216788 1716670.423155728 0.026097723062979167 0.020206746472777627 5.8115351396763286e-08 7.235709131873599 -0.0499485949127898 ATSEEDVSIKS(ph)PICEK ddPTM_A459_Selumetinib_30min_R2 1 ATSEEDVSIKSPICEK 16 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ATSEEDVS(0.004)IKS(0.996)PICEK 66.63600000000001 0.028912 11822000.0 55908.0 47167.0 57164.0 58253.0 57936.0 44977.0 55499.0 60812.0 48311.0 49989.0 True False 52800.85717745655 50784.55723419104 53486.130475457285 50318.840907969934 50657.56172558847 51172.17348944506 58079.81346918221 60988.952852031456 57974.54992212349 48545.68768297995 1.0876528832440138 1.0461188142154185 1.10176893207776 1.0365254528181636 1.0435028144291576 1.0541033803788498 1.1963949063501456 1.2563207107150343 1.1942265665431966 1.0 15.567055526178608 -7.259545921175889 24.89654042755833 1.1830956089953981 1.0607696713466173 0.3421829052067321 0.06537227894221133 145.41465344472215 1912026.7653055862 0.024573099715559606 0.018059173413719362 5.5011574961800425e-08 7.259545921175889 -0.12232593764878086 ATSSS(ph)SGSLSATGR ddPTM_A459_Selumetinib_30min_R1 3 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 1 ATS(0.001)S(0.018)S(0.9)S(0.062)GS(0.018)LSATGR;ATS(0.005)S(0.068)S(0.926)S(0.001)GSLSATGR;AT(0.001)S(0.014)S(0.281)S(0.59)S(0.088)GS(0.023)LS(0.003)ATGR 248.67 2.2546999999999995e-27 166768200.0 6004.200000000001 6320.5 7073.799999999999 7245.900000000001 7749.300000000001 5774.7 6382.1 6653.4 3611.7799999999997 4996.97 True False 6144.0861778605595 5580.492921679268 6113.216813602052 5980.539587388633 7048.37718325004 5716.61176100809 5900.69305874181 6476.9302187109615 6128.926866025904 5638.379774109632 1.0896900216039074 0.989733424361344 1.084215157282023 1.0606840665203385 1.2500713796567673 1.0138749055637728 1.0465228124286112 1.1487218807877742 1.0870014279933342 1.0 12.461064938833692 -5.4841209686752395 18.013845078803634 1.0932587235017763 1.0390262340079293 0.05890205331025866 0.07137678821536073 51.44314832680073 23905.59095896373 0.018367356066067604 0.03816488939014814 3.2800391795734005e-06 5.4841209686752395 -0.05423248949384707 ATSSS(ph)SGSLSATGR ddPTM_A459_Selumetinib_30min_R2 1 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 1 ATSS(0.002)S(0.533)S(0.156)GS(0.309)LSATGR 231.07 2.2453000000000005e-13 50085000.0 14454.0 13867.0 17773.0 22861.0 15898.0 11764.0 14685.0 14771.0 14698.0 14302.0 True False 13650.704543946422 14930.554310567275 16629.504529779264 19747.292362575336 13900.751110076717 13384.384217040524 15367.881597775457 14813.981164529312 17638.010696432928 13889.06409894134 0.9828383285369756 1.0749863492749896 1.1973092219400734 1.421787114084996 1.0008414541866983 0.9636635068924994 1.1064735167394637 1.0665931886410165 1.269920749935724 1.0 13.761661767543579 ATSSSNPSS(ph)PAPDWYK ddPTM_A459_Selumetinib_30min_R2 1 ATSSSNPSSPAPDWYK 16 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 ATSSSNPS(0.063)S(0.937)PAPDWYK 337.35 1.807199999999999e-136 8579100.0 34794.0 22280.0 30450.0 42870.0 43884.0 39284.0 44322.0 52628.0 44537.0 25573.0 True False 32860.28877141773 23988.80435850861 28490.88015145327 37031.03204512511 38370.89959206235 44695.01441535358 46383.06082237684 52781.13876696556 53445.644467753 24834.641043366468 1.3231634278118538 0.9659412558699418 1.1472233523207462 1.49110397772455 1.5450555345277086 1.7997044667288227 1.867675910490606 2.1253030665834336 2.1520602763867513 1.0 14.600066273951029 -6.23996595669605 1.2419552049719986 1.8734386632207396 1.115296354531611 0.4151310816808803 0.31687926030441815 0.38170278202868707 1.2028424134226947 0.12272473125622582 0.18112683135992885 5.754850464631758e-07 6.23996595669605 -0.7581423086891286 ATSSSS(ph)GSLSATGR ddPTM_A459_Selumetinib_30min_R2 1 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 1 ATSS(0.137)S(0.137)S(0.639)GS(0.087)LSATGR 263.89 3.6282e-36 52333000.0 17801.0 14890.0 17573.0 25098.0 19351.0 15720.0 16843.0 16808.0 20145.0 17876.0 True False 16811.69168304901 16032.01512110383 16442.372312035728 21679.60910353508 16919.95437986506 17885.287308048017 17626.232873771343 16856.90849728581 24174.562898329117 17359.87343257416 0.9684224800569953 0.9235099082589663 0.9471481676348614 1.2488345141304626 0.9746588559866091 1.0302659968988004 1.0153433976481294 0.9710271542449967 1.3925540985205478 1.0 14.083468808964144 -5.584323534257987 24.9999947622479 1.0802052947871228 0.9433011974046103 0.20783431629927085 0.1277553008553039 106.68457930818369 43405.7638016167 0.033790941281047204 0.05852763716625388 2.604212779396802e-06 5.584323534257987 -0.13690409738251252 ATSSSSGS(ph)LSATGR ddPTM_A459_Selumetinib_30min_R1 2 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 1 ATSSS(0.005)S(0.356)GS(0.639)LSATGR;ATSS(0.001)S(0.007)S(0.328)GS(0.65)LS(0.014)ATGR 228.7 3.2899e-13 33451000.0 3999.9 4068.1 4509.2 4356.3 4628.6 3516.3999999999996 4289.5 4023.0 2196.5 2815.7 True False 4093.089887549453 3591.8049607916173 3896.875407262626 3595.553982878746 4209.943947245703 3481.0282086357465 3965.9395615037383 3916.2969714543246 3727.3000739873128 3177.122522240575 1.2883009260413785 1.1305213870878985 1.2265423759970282 1.1317013925994532 1.3250807665663333 1.0956543804237209 1.2482803334593695 1.232655317520606 1.1731685032274868 1.0 11.633505011736002 -8.651730410844293 5.564054224379964 1.0000012434810663 1.2063368437167261 0.4534460928441869 0.06873866099230473 1.7677515878416559 76.01448256837709 0.060725620581924475 0.015757803469304568 2.2298188842154907e-09 8.651730410844293 0.20633560023565978 ATSSSSGS(ph)LSATGR ddPTM_A459_Selumetinib_30min_R2 4 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 1 ATSS(0.031)S(0.096)S(0.096)GS(0.588)LS(0.187)AT(0.001)GR;ATSSS(0.001)S(0.027)GS(0.947)LS(0.024)ATGR;ATS(0.001)S(0.096)S(0.01)S(0.327)GS(0.557)LS(0.01)ATGR;AT(0.001)S(0.01)S(0.024)S(0.017)S(0.092)GS(0.854)LS(0.003)ATGR 195.71 0.00012009 33431400.0 44418.9 37795.4 50825.3 56246.0 56119.0 40216.3 36623.0 41297.3 42804.4 44354.8 True False 41950.27536094523 40694.1856486345 47555.255532402545 48585.19777023806 49068.82950977458 45755.73027777683 38326.04206709777 41417.46830586394 51366.4760548642 43074.16167638957 0.9739081093698827 0.9447470145644269 1.1040320619511723 1.1279429681128137 1.139170853246597 1.062254690446062 0.8897687285253792 0.9615385812271369 1.1925124960242681 1.0 15.394535098063871 -5.249396002051831 24.26542351132622 1.0575834630233334 0.9593275437083171 0.18017724314579975 0.08550996893954058 976.409439880606 1967291.2741769883 0.0236152059170163 0.06139630366141803 5.631239492337628e-06 5.249396002051831 -0.09825591931501632 ATSSSSGSLS(ph)ATGR ddPTM_A459_Selumetinib_30min_R1 2 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 1 ATSSSSGSLS(1)ATGR;ATSSSSGSLS(0.998)AT(0.002)GR 214.61 1.0542e-06 12472200.0 2644.1 2688.5 2897.6 2907.8 3182.5 2613.5 2764.3 2343.14 1958.9099999999999 2468.2400000000002 True False 2705.702385477017 2373.729170150258 2504.1218353774925 2400.0073161661985 2894.6434369160115 2587.2105628681393 2555.786625449301 2280.9923156086224 3324.1271968743386 2785.0626466935664 0.971505035511224 0.8523072804011628 0.8991258556967803 0.8617426681642129 1.0393458977852938 0.9289595571358807 0.9176765299996169 0.8190093383775846 1.1935556282084896 1.0 11.44349406431272 -8.260777457473289 24.99999985205951 1.0967778129871526 0.9122724760472408 0.5063073088622239 0.07329096585134874 46.13382517294033 1742593.202346242 0.05511855037153622 0.01798450111303585 5.48557986700256e-09 8.260777457473289 -0.18450533693991178 ATST(ph)ATSGFAGAIGQK ddPTM_A459_Selumetinib_30min_R2 1 ATSTATSGFAGAIGQK 16 0 E7ER27;A0A2R8YD50;P51659-3;P51659;P51659-2;A0A2R8Y7L2;E7ET17;E7EPL9 E7ER27 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 1 ATS(0.297)T(0.702)AT(0.001)SGFAGAIGQK 134.4 0.0010639000000000002 7144300.0 42555.0 36904.0 40384.0 50356.0 57155.0 36954.0 38996.0 49205.0 32597.0 39340.0 True False 40189.96346116231 39734.41813493724 37785.737406774664 43497.4259310548 49974.677927817014 42044.07806498771 40809.39126910807 49348.17840367376 39117.310836278695 38204.15198240473 1.051978944060116 1.0400549697644719 0.989047929245419 1.138552321514372 1.3080954643577303 1.1005107006262433 1.068192569433375 1.2916967356428044 1.0239020841057938 1.0 15.221441816735025 -5.80883680131211 8.561451033134258 1.1486520620997018 1.0284492728606807 0.18767892965836674 0.09729568553644914 0.3806930642046442 62.83924300015196 0.026617367556214452 0.039776938230026974 1.5529704738079963e-06 5.80883680131211 -0.12020278923902117 ATST(ph)SPNSQSSK ddPTM_A459_Selumetinib_30min_R1 1 ATSTSPNSQSSK 12 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 ATS(0.027)T(0.314)S(0.314)PNS(0.314)QS(0.027)S(0.003)K 180.61 0.00024322 2813900.0 2413.4 5417.1 4304.5 3684.7 4111.7 3558.3 3683.6 5218.1 2820.9 2783.1 True False 2469.627524341073 4782.863413658534 3719.972542926011 3041.2363153853735 3739.7974609795956 3522.506732677901 3405.743086316627 5079.6990372224245 4786.861269615665 3140.3379946896844 0.7864209293767792 1.523040966210122 1.1845771217036158 0.9684423525518935 1.1908901103332183 1.1216966895392995 1.0845148172189563 1.6175644296289768 1.5243140317094064 1.0 11.61670412945423 -7.743729670620816 24.99472968867045 1.4282044735812283 1.137207505807596 0.1965345289220738 0.23173187371356685 317.3866119325341 447947.16859262553 0.10487046877703529 0.060379669029765645 1.804140390153221e-08 7.743729670620816 -0.29099696777363215 ATST(ph)SPNSQSSK ddPTM_A459_Selumetinib_30min_R2 2 ATSTSPNSQSSK 12 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 ATS(0.019)T(0.468)S(0.468)PNS(0.043)QS(0.001)SK;ATS(0.006)T(0.727)S(0.131)PNS(0.131)QS(0.004)SK 187.74 0.0002779 4150300.0 16149.9 16049.6 19148.4 17096.9 17343.0 13042.7 26890.0 39181.0 21578.0 28907.0 True False 15252.353211172025 17280.552712402143 17916.412791201554 14768.272726202445 15164.217291612824 14839.213535157638 28140.43828152414 39295.01022323628 25894.2029396945 28072.379800594135 0.5433224158234429 0.615571349317396 0.6382220858533113 0.5260784027255817 0.540182820242831 0.5286054705929696 1.002424392994589 1.3997748143320796 0.9224085426183378 1.0 14.776863751236844 -7.347235727550329 4.266522276879383 1.1323467593283556 0.5676789332391312 0.8111097624190651 0.12215076859781396 0.08692218463362501 2.873337088654628 0.050592233157612874 0.03339325244659679 4.4953578839325945e-08 7.347235727550329 -0.5646678260892244 ATSTS(ph)PNSQSSK ddPTM_A459_Selumetinib_30min_R1 1 ATSTSPNSQSSK 12 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 ATST(0.059)S(0.88)PNS(0.059)QS(0.001)SK 257.2 5.8704999999999985e-25 3482800.0 1319.7 3481.1 2827.4 2526.3 2760.5 2316.7 2247.0 2832.4 1725.6 1635.4 True False 1350.4464423108127 3073.5311936805138 2443.4546097964944 2085.1291295242677 2510.813262405858 2293.396101395298 2077.5069809299225 2757.2755510681654 2928.2171671625338 1845.3195201449857 0.7318225529878473 1.6655821174205256 1.324136326051823 1.1299556021389945 1.3606387593020122 1.242817884035122 1.1258250716204932 1.494199525322058 1.5868347650343315 1.0 10.849654927623888 -7.769125243946689 24.939344305561033 1.4053878319041577 1.2486717525294142 0.039151754519108684 0.2633529639375388 508.1170455507367 1648722.329071162 0.133511825666329 0.06603260194835744 1.7016677024518628e-08 7.769125243946689 -0.15671607937474352 ATSTS(ph)PNSQSSK ddPTM_A459_Selumetinib_30min_R2 1 ATSTSPNSQSSK 12 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 ATS(0.007)T(0.141)S(0.799)PNS(0.017)QS(0.031)S(0.005)K 78.098 0.044596 1701500.0 6334.3 7546.1 8976.8 6944.3 6756.5 7896.5 10177.0 16927.0 9578.3 13588.0 True False 5982.264964211974 8124.861605464181 8399.242461200838 5998.474360414328 5907.688066123625 8984.171197710002 10650.250665342926 16976.254767584294 11494.227640062829 13195.67913413613 0.45335029015189904 0.6157213677957534 0.63651460268329 0.4545786768107123 0.4476986751550305 0.6808418957739504 0.8071013668248124 1.286501027724153 0.8710599525209896 1.0 13.687777982448333 -7.352105510124317 2.3456222610693467 1.056758476435205 0.5358065053105597 0.7705439693607851 0.12348204269448439 0.1346160559230052 1.4464999096376139 0.05982895629861975 0.036645484588707374 4.445232591843021e-08 7.352105510124317 -0.5209519711246452 ATSVALPGWS(ph)PSETR ddPTM_A459_Selumetinib_30min_R1 2 ATSVALPGWSPSETR 15 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 ATSVALPGWS(0.839)PS(0.161)ET(0.001)R;ATSVALPGWS(0.869)PS(0.13)ETR 177.39 1.9502e-05 21951700.0 9762.8 10778.5 10789.0 11323.1 10448.099999999999 9101.9 10482.3 9738.4 4920.1 8490.0 True False 9990.254244898073 9516.548209211294 9323.913059734869 9345.733145911507 9503.07119976187 9010.34314986398 9691.611671651854 9480.10599721869 8349.050350113803 9579.774199603105 1.0428486138339226 0.9934000542106274 0.9732915270718138 0.9755692515486122 0.9919932350968759 0.9405590321990348 1.0116743327889066 0.9895959758228389 0.8715289291953988 1.0 13.225775935931269 -1.52287923878726 0.8241946600321732 0.9679977133887924 23.07229292775765 0.2666705752009416 0.037470218759092504 799.0548535178362 2.4968541497799457 0.01285405064845605 33050.071306206744 0.029999965909768878 1.52287923878726 22.104295214368857 ATSVALPGWSPS(ph)ETR ddPTM_A459_Selumetinib_30min_R2 3 ATSVALPGWSPSETR 15 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 ATSVALPGWS(0.427)PS(0.55)ET(0.022)R;ATSVALPGWS(0.238)PS(0.758)ET(0.004)R;ATSVALPGWS(0.422)PS(0.576)ET(0.002)R 165.24 8.7691e-05 12000800.0 87499.0 82385.0 102755.0 106363.0 103314.0 74961.0 79279.0 79907.0 75002.0 83271.0 True False 82636.15586624932 88703.66459047268 96143.85517118474 91876.17591359076 90334.77168112135 85286.19732179315 82965.63058835822 80139.51614068406 90004.49573097458 80866.74986595914 1.0218805133534248 1.096911459128797 1.188917018806224 1.1361428036353671 1.117081765136548 1.0546509840343463 1.0259548049832359 0.9910070118252495 1.1129975655032722 1.0 16.303259008483373 -6.853834613528237 3.527030139947039 1.0325732994890777 1.1173194784583198 0.37135542037881253 0.049342682454815864 0.26071873448563837 6.340800524450643 0.01886375006953787 0.01671031707140869 1.40012040991029e-07 6.853834613528237 0.08474617896924208 ATT(ph)PADGEEPAPEAEALAAAR ddPTM_A459_Selumetinib_30min_R1 3 ATTPADGEEPAPEAEALAAAR 21 0 Q5JZ02;Q96S44 Q5JZ02 TP53RK TP53-regulating kinase 1 AT(0.004)T(0.996)PADGEEPAPEAEALAAAR;AT(0.141)T(0.859)PADGEEPAPEAEALAAAR;AT(0.008)T(0.992)PADGEEPAPEAEALAAAR 236.27 1.7274e-30 23879200.0 2363.96 2369.54 2700.02 2736.81 2888.87 2498.46 2436.09 2005.4099999999999 1145.97 2150.8999999999996 True False 2419.0356685345664 2092.113155230741 2333.3721141482374 2258.8775097863722 2627.5722185714235 2473.3277608201747 2252.33376999269 1952.2200123102698 1944.6273916627542 2426.9889665402043 0.9967229772713077 0.8620200520372181 0.9614267499017837 0.9307325006122779 1.0826469567009036 1.0190931211137844 0.9280362626466762 0.804379434445167 0.8012510227580141 1.0 11.24495183445566 -7.562868678417607 6.037770997979738 0.8533373185074732 0.9726840753402675 0.28537563237862074 0.07457150624381567 0.22260460771506801 21.052828204338407 0.03625816316862603 0.020900187236469133 2.736095939511378e-08 7.562868678417607 0.11934675683279428 ATT(ph)PADGEEPAPEAEALAAAR ddPTM_A459_Selumetinib_30min_R2 1 ATTPADGEEPAPEAEALAAAR 21 0 Q5JZ02;Q96S44 Q5JZ02 TP53RK TP53-regulating kinase 1 AT(0.232)T(0.768)PADGEEPAPEAEALAAAR 67.655 0.01952 11419000.0 29167.0 22953.0 34997.0 35840.0 45916.0 28128.0 24466.0 29087.0 27349.0 30047.0 True False 27546.01490475199 24713.421294472555 32745.33112185255 30958.530172551524 40147.62158575185 32002.376679438614 25603.71747845928 29171.638354387924 32819.56419490706 29179.465038518447 0.9440205592662437 0.846945660650376 1.1222046421559466 1.060969765267616 1.3758861422837894 1.0967430909783225 0.8774567129541617 0.9997317742419132 1.124748659770955 1.0 14.832665813410078 -5.263546964745229 24.966188355004665 1.0851432114393258 0.8954831031889537 0.27010003354048207 0.12271203892320562 241.6554084322392 2862662.071775016 0.03459923136223781 0.07833504321648206 5.45070948353666e-06 5.263546964745229 -0.18966010825037205 ATT(ph)PASTANSDVATIPTDTPLKEENEGFVK ddPTM_A459_Selumetinib_30min_R2 1 ATTPASTANSDVATIPTDTPLKEENEGFVK 30 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 AT(0.218)T(0.659)PAS(0.043)T(0.043)ANS(0.037)DVATIPTDTPLKEENEGFVK 68.94800000000001 0.00045113 5865300.0 20523.0 20818.0 22596.0 23847.0 21696.0 16052.0 20940.0 19008.0 18929.0 24334.0 True False 19382.413820078356 22414.673659579556 21142.19796066463 20598.997461630475 18970.35451529907 18263.017294452085 21913.751491822826 19063.31013305621 22715.328920450323 23631.414192675056 0.8201969489446067 0.948511734288308 0.8946649484573802 0.8716785755469291 0.8027600193804416 0.7728279461206772 0.9273144346399443 0.8066935807407242 0.9612344286822797 1.0 14.528418347740171 -8.428233729373833 4.934205381396807 0.998973154382813 0.8587067163220719 0.4681962422361631 0.05389266368084183 0.18650834096759128 6.783099130245533 0.053398985194260555 0.01390969986446926 3.730493354087265e-09 8.428233729373833 -0.14026643806074113 ATT(ph)PPNQGRPDS(ph)PVYANLQELK ddPTM_A459_Selumetinib_30min_R1 4 ATTPPNQGRPDSPVYANLQELK 22 1 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 2 AT(0.044)T(0.956)PPNQGRPDS(0.998)PVY(0.002)ANLQELK;AT(0.324)T(0.844)PPNQGRPDS(0.796)PVY(0.037)ANLQELK;AT(0.193)T(0.807)PPNQGRPDS(0.998)PVY(0.002)ANLQELK;AT(0.051)T(0.952)PPNQGRPDS(0.992)PVY(0.005)ANLQELK 97.085 0.00063613 166575000.0 17489.9 20560.4 21478.699999999997 22069.6 21788.8 17427.0 19142.3 18534.7 11180.900000000001 15667.0 True False 17897.380640578824 18153.17880972936 18562.01051405388 18215.55865770051 19818.00688712509 17251.70020244999 17698.380899445856 18043.09954680945 18973.170679373896 17678.012059503166 1.012409120456377 1.0268789696843068 1.0500055352137574 1.0304076383921446 1.121054042752026 0.9758846268676458 1.0011522132621093 1.0206520668770573 1.0732638158358134 1.0 14.10966842842206 -9.21756911254553 15.212543908034377 0.9999999999998433 1.0341517406198435 0.06899631192560529 0.03813007594907614 0.0 0.0 0.0373452306260598 0.00905754885201742 6.059417647860576e-10 9.21756911254553 0.03415174062000015 ATT(ph)PPNQGRPDS(ph)PVYANLQELK ddPTM_A459_Selumetinib_30min_R2 4 ATTPPNQGRPDSPVYANLQELK 22 1 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 2 AT(0.182)T(0.818)PPNQGRPDS(0.695)PVY(0.305)ANLQELK;AT(0.058)T(0.942)PPNQGRPDS(0.993)PVY(0.007)ANLQELK;AT(0.157)T(0.843)PPNQGRPDS(0.81)PVY(0.19)ANLQELK;AT(0.045)T(0.955)PPNQGRPDS(0.986)PVY(0.014)ANLQELK 81.15100000000002 0.0036469 160490500.0 484414.0 436041.0 475984.0 463508.0 475071.0 337770.0 376624.0 383940.0 301553.0 434533.0 True False 457492.2091428858 469483.9426072014 445359.7076521956 400377.4108041007 415388.33379137394 384294.7515292232 394137.76226629777 385057.20183531183 361872.0260948042 421986.903237678 1.084138407217842 1.1125557191588276 1.055387511401872 0.9487910826905306 0.9843630942200414 0.9106793328909897 0.9340047267872326 0.912486143245147 0.8575432633533299 1.0 18.686838698660132 -5.7470009020504875 1.2514005833860422 0.9220100136888718 1.1108917901504871 0.7599381533138102 0.038569251291163884 0.22263159565158477 0.6852947838605498 0.013107540351783319 0.03446801900961015 1.7906021348648386e-06 5.7470009020504875 0.1888817764616153 ATT(ph)PPNQGRPDSPVYANLQELK ddPTM_A459_Selumetinib_30min_R2 1 ATTPPNQGRPDSPVYANLQELK 22 1 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 AT(0.063)T(0.824)PPNQGRPDS(0.105)PVY(0.008)ANLQELK 60.81399999999999 0.019824 13776000.0 35492.0 31344.0 29772.0 32281.0 30500.0 24041.0 28977.0 27837.0 22486.0 29726.0 True False 33519.49672573315 33747.98401315505 27856.501933302683 27884.272112168932 26668.31732654046 27352.429527530712 30324.48791683619 27918.00106133658 26983.828311334237 28867.733142576606 1.1611405911292607 1.1690555627099322 0.9649701899252189 0.9659321698191403 0.9238105809980535 0.9475087424578207 1.0504630816373677 0.9671005660004776 0.934740118943949 1.0 14.817170203009583 -5.261512493993856 24.996605879610502 0.9685139778537498 1.1650980949811547 0.8439409803557272 0.03367470638023844 2.241192809949424 766538.04005996 0.00919243841034302 0.021338192116129997 5.476303462404188e-06 5.261512493993856 0.19658411712740487 ATT(ph)PSLPSVDNEFK ddPTM_A459_Selumetinib_30min_R1 2 ATTPSLPSVDNEFK 14 0 A0A087WU78;A0A087WWC4;Q6T4R5-4;Q6T4R5-3;Q6T4R5-2;Q6T4R5 A0A087WU78 NHS Nance-Horan syndrome protein 1 ATT(0.999)PS(0.001)LPSVDNEFK;AT(0.009)T(0.988)PS(0.004)LPSVDNEFK 185.2 0.00018487 30783000.0 7865.099999999999 8074.3 10332.900000000001 8620.6 8700.7 7980.7 7471.5 8356.2 5372.1 6805.7 True False 8048.341527179482 7128.957202359769 8929.748934556908 7115.174038703602 7913.723221233347 7900.421403895828 6907.91873966084 8134.566431237039 9116.06133733997 7679.277888131789 1.048059680144936 0.9283369225871443 1.1628370615885257 0.9265420710585299 1.0305296066266714 1.0287974362935626 0.8995531663643697 1.0592879369307486 1.1870987702409765 1.0 12.90675493985444 -7.996063264297292 24.987835231016785 1.10343072498831 1.0039232838640875 0.16462243457046621 0.08295827764524495 159.83022237782768 1014499.6051371153 0.04290044728086238 0.02046268244338621 1.0091058774754308e-08 7.996063264297292 -0.0995074411242225 ATT(ph)PSLPSVDNEFK ddPTM_A459_Selumetinib_30min_R2 2 ATTPSLPSVDNEFK 14 0 A0A087WU78;A0A087WWC4;Q6T4R5-4;Q6T4R5-3;Q6T4R5-2;Q6T4R5 A0A087WU78 NHS Nance-Horan syndrome protein 1 ATT(0.999)PS(0.001)LPSVDNEFK;AT(0.004)T(0.996)PSLPSVDNEFK 178.22 0.00016667 39322000.0 114699.0 89675.0 105611.0 99690.0 91727.0 76970.0 108283.0 91469.0 68458.0 86790.0 True False 108324.48875647657 96552.78414942803 98816.10324056259 86112.05002515789 80203.43421021568 87571.91883590686 113318.37405869387 91735.159646492 82151.51287633748 84284.14719249881 1.2852296946075918 1.1455628058845817 1.1724162435300418 1.021687385985935 0.9515838610437253 1.03900818544084 1.3444802828684141 1.0884034863279286 0.9746970885130919 1.0 16.36297368310725 -4.7745734878471815 1.2797567621673611 1.074873209202015 1.3709174801150206 0.27854602617525304 0.10712453204485757 2.2221705131316685 3.1214874009042695 0.034620190719137446 0.8758831889389314 1.680453548707505e-05 4.7745734878471815 0.29604427091300556 ATTPPNQGRPDS(ph)PVYANLQELK ddPTM_A459_Selumetinib_30min_R1 3 ATTPPNQGRPDSPVYANLQELK 22 1 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 ATT(0.001)PPNQGRPDS(0.948)PVY(0.051)ANLQELK;ATTPPNQGRPDS(0.998)PVY(0.002)ANLQELK;ATTPPNQGRPDS(0.734)PVY(0.266)ANLQELK 114.34 1.9109e-05 81769000.0 4867.7 4445.18 5670.9 6625.5 5243.0 4362.08 4728.490000000001 4645.87 2449.36 3755.6400000000003 True False 4981.1079391046 3924.736259091882 4900.822928023956 5468.480801038294 4768.771575726834 4318.201435651752 4371.816192370859 4522.646435687422 4156.385025823612 4237.7129770315 1.1754236226243537 0.9261448994691338 1.1564782595202947 1.290432086995411 1.1253172646598966 1.0189933719099198 1.0316451859921147 1.0672375548321154 0.9808085277014542 1.0 12.049070161037546 -6.7454461251234115 7.55290107448853 1.024570518114716 1.1333111044456619 0.3070641439818068 0.08624665762336753 0.23335864769995066 66.19663655791125 0.031196311184194355 0.030163060813209266 1.7970239898464784e-07 6.7454461251234115 0.10874058633094585 ATTPPNQGRPDS(ph)PVYANLQELK ddPTM_A459_Selumetinib_30min_R2 2 ATTPPNQGRPDSPVYANLQELK 22 1 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 ATTPPNQGRPDS(0.713)PVY(0.287)ANLQELK;ATTPPNQGRPDS(0.874)PVY(0.126)ANLQELK 88.071 0.00028073 107663000.0 64830.0 60282.0 68415.0 65734.0 67276.0 49282.0 55139.0 58083.0 48032.0 56682.0 True False 61227.008135052376 64905.435562819446 64013.25338461978 56780.91580252517 58824.18742492901 56070.14816254601 57703.072755855705 58252.01191384171 57639.7421262122 55045.443382477504 1.1122992998643488 1.1791245846060467 1.1629164822931914 1.031527994206331 1.0686477174176852 1.0186156149737673 1.0482806425031759 1.058253114777979 1.0471301271153088 1.0 15.748335523146855 -5.760849763810365 24.99999304909745 1.0421317722742172 1.154214590018407 0.8173804974902786 0.024329916116600493 5.861059781128239 248486.67787368517 0.006433363427485157 0.010338025726763416 1.7344038791166697e-06 5.760849763810365 0.11208281774418993 ATVPVAAATAAEGEGS(ph)PPAVAAVAGPPAAAEVGGGVGGSSR ddPTM_A459_Selumetinib_30min_R1 2 ATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSR 41 0 O75179-4;O75179-6;O75179-2;O75179;H0YLQ3;A0A1W2PQ15;O75179-5;O75179-3 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 ATVPVAAATAAEGEGS(1)PPAVAAVAGPPAAAEVGGGVGGSSR;ATVPVAAATAAEGEGS(1)PPAVAAVAGPPAAAEVGGGVGGSSR 126.91 9.684899999999999e-36 22514800.0 1244.3899999999999 1268.68 1336.8899999999999 1249.5 1204.54 969.94 946.03 837.73 621.5 760.47 True False 1273.3818658385624 1120.1423558066688 1155.3476810111176 1031.2982810199005 1095.58956967881 960.1832842350568 874.6701954468778 815.5106790694583 1054.6401074359724 858.0837321050857 1.4839832270385205 1.305399827425571 1.3464276710814362 1.2018620589506783 1.2767863189657092 1.118985535222182 1.019329655977863 0.9503858989015146 1.2290643301775301 1.0 9.744974623045852 -5.923460180826799 0.5249660738485885 1.0252350648668416 1.4946946211429104 0.7194943659791357 0.08556300471343369 0.8232078245319764 0.3851033411816647 0.06354389204219342 0.20963714242136386 1.1927236181343286e-06 5.923460180826799 0.46945955627606883 ATVPVAAATAAEGEGS(ph)PPAVAAVAGPPAAAEVGGGVGGSSR ddPTM_A459_Selumetinib_30min_R2 2 ATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSR 41 0 O75179-4;O75179-6;O75179-2;O75179;H0YLQ3;A0A1W2PQ15;O75179-5;O75179-3 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 ATVPVAAAT(0.001)AAEGEGS(0.999)PPAVAAVAGPPAAAEVGGGVGGSSR;ATVPVAAAT(0.001)AAEGEGS(0.999)PPAVAAVAGPPAAAEVGGGVGGSSR 106.26 1.9087999999999998e-22 13841600.0 9629.2 10314.8 13045.4 14595.7 11534.900000000001 8732.4 7326.7 7223.900000000001 5660.9 11791.2 True False 9094.04761274173 11105.911992690515 12206.073166757576 12607.740481013116 10085.782738685622 9935.208835165306 7667.40606758063 7244.9203530189725 6793.238178761546 11450.757418783189 0.7941874305907797 0.9698844876822725 1.0659620774723084 1.101039871854422 0.8807961228958936 0.8676464334899051 0.6695981573239376 0.6327022823079639 0.5932566668138732 1.0 13.483155409153945 -6.955061392202647 2.0459390395452526 0.6940403181417771 0.982347689705411 0.41292686903461007 0.13182867157246267 0.28136028446376143 2.38402934525622 0.05664296957595963 0.045512451665702496 1.1090180325374645e-07 6.955061392202647 0.28830737156363384 ATVS(ph)PGPHAGEAEPPSR ddPTM_A459_Selumetinib_30min_R1 1 ATVSPGPHAGEAEPPSR 17 0 O15055 O15055 PER2 Period circadian protein homolog 2 1 AT(0.012)VS(0.988)PGPHAGEAEPPSR 99.409 0.0031748 5323000.0 2496.7 2828.8 2532.1 2997.6 2770.2 1955.5 2465.8 2698.5 1344.8 2194.6 True False 2554.868252267489 2497.6027809265597 2188.2547278297025 2474.1254319209716 2519.635899118533 1935.8294454519403 2279.80272077303 2626.9270140366634 2282.0273796941224 2476.298287214251 1.0317287967523598 1.0086033632629434 0.8836797808762419 0.9991225389507805 1.017500965908689 0.7817432396763803 0.9206494760926918 1.0608281835835958 0.9215478569269308 1.0 11.273969392253505 -5.028969233635493 18.85658460823064 0.9475779193782443 1.025948067624095 0.1319446046216084 0.07492663896652359 59.14910405840884 38506.29617521954 0.019581312696072047 0.052381369515705004 9.354719426647457e-06 5.028969233635493 0.07837014824585076 ATVS(ph)PGPHAGEAEPPSR ddPTM_A459_Selumetinib_30min_R2 1 ATVSPGPHAGEAEPPSR 17 0 O15055 O15055 PER2 Period circadian protein homolog 2 1 AT(0.164)VS(0.836)PGPHAGEAEPPSR 69.255 0.022952 3155900.0 14933.0 13818.0 17177.0 15539.0 17331.0 11794.0 19298.0 16577.0 13199.0 13980.0 True False 14103.083641535348 14877.79616812711 16071.850520903534 13422.561393729859 15153.724838894183 13418.516444727631 20195.39523826155 16625.236325529924 15839.168810873476 13576.361075597828 1.0387970357450387 1.0958603771130162 1.1838113638411623 0.9886715091760185 1.1161845765970022 0.9883735685879844 1.487541111039009 1.2245723454874922 1.1666726247685635 1.0 13.728809219831932 -7.174626075100631 24.999968491919507 1.2385030318875192 1.0736192629068166 0.25630996369684966 0.12425894449699645 95.3788188989383 27464.539051219475 0.04571506539737629 0.0354107309127311 6.689196054004907e-08 7.174626075100631 -0.16488376898070256 ATVT(ph)PSPVK ddPTM_A459_Selumetinib_30min_R2 1 ATVTPSPVK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 AT(0.001)VT(0.65)PS(0.349)PVK 117.71 0.017415 475420000.0 543590.0 438250.0 508560.0 505360.0 496480.0 446550.0 491010.0 523550.0 433340.0 447980.0 True False 513379.44396318187 471862.365804147 475839.8032782626 436529.0962053752 434107.74381248525 508058.2091227003 513842.9379178576 525073.4438216317 520020.1085312449 435045.65340817784 1.1800587822021245 1.0846272387910199 1.0937698136977132 1.00340985546132 0.9978441122481171 1.1678273421249863 1.181124173732978 1.2069387194382244 1.1953230757677298 1.0 18.73080727882254 -6.793832068448881 24.961905432970354 1.1651065063028692 1.0700520134477123 0.21225614544611016 0.07260766272073162 252.33351823360067 194447.25339086194 0.02564742266499662 0.02262055174874179 1.6075627398810872e-07 6.793832068448881 -0.09505449285515688 ATVTPS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 6 ATVTPSPVK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 ATVT(0.225)PS(0.775)PVK;AT(0.096)VT(0.351)PS(0.553)PVK;ATVT(0.16)PS(0.84)PVK;ATVT(0.265)PS(0.734)PVK;ATVT(0.087)PS(0.913)PVK;ATVT(0.218)PS(0.782)PVK 150.09 0.0013571 5050579000.0 96820.7 126360.0 68589.4 73619.8 73639.4 78715.7 89798.5 79527.3 43053.9 78930.8 True False 99076.43392971298 111565.71245682967 59275.33621460552 60763.483944801024 66978.72927209207 77923.89152613723 83024.92684781298 77417.97766292312 73059.3237675586 89062.33703109952 1.1124391884654525 1.252669940806429 0.6655488525290693 0.6822579102497964 0.7520432486372313 0.8749365233805523 0.932211410742811 0.8692560766274263 0.8203167152692966 1.0 16.44252784871788 -5.253462556565231 24.975052204167614 0.8178720481101142 1.1825545983113217 0.6548001344919598 0.10387785499167196 362.8900363500431 1136184.6532113482 0.028201403106313815 0.07181694831601194 5.578756982666009e-06 5.253462556565231 0.36468255020120754 ATVTPS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 6 ATVTPSPVK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 ATVT(0.078)PS(0.922)PVK;AT(0.06)VT(0.398)PS(0.542)PVK;ATVT(0.024)PS(0.976)PVK;AT(0.003)VT(0.083)PS(0.914)PVK;AT(0.001)VT(0.014)PS(0.985)PVK;AT(0.038)VT(0.131)PS(0.831)PVK 129.0 0.0041885 6896090100.0 15459909.0 12360998.0 13933954.0 14598702.0 15048757.0 12490672.0 15069926.0 14547140.0 12231639.0 12146507.0 True False 14600709.14869919 13309046.799726976 13037458.569782035 12610333.603434369 13158197.608065484 14211148.688968897 15770707.419491878 14589469.768991327 14678308.58054881 11795805.782494737 1.2377881950520921 1.128286362554216 1.1052622271155008 1.0690523255434072 1.115497987224626 1.2047628581727403 1.3369758463551504 1.236835366570926 1.2443667563882561 1.0 23.491770637998968 -6.848275255872351 5.025381890343294 1.2299833372551756 1.1262634065152861 0.11567362938312542 0.09001667809799402 0.31488507451225456 13.542324466711568 0.031191948613943213 0.02764872297531101 1.4181584078940237e-07 6.848275255872351 -0.1037199307398895 ATVTPS(ph)PVKGK ddPTM_A459_Selumetinib_30min_R1 3 ATVTPSPVKGK 11 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 ATVT(0.168)PS(0.831)PVKGK;ATVT(0.012)PS(0.988)PVKGK;ATVT(0.319)PS(0.68)PVKGK 143.42 0.0039894 3733768000.0 18777.8 24419.4 22529.9 27425.7 19317.7 17529.899999999998 18312.199999999997 17016.6 10661.499999999998 13915.3 True False 19215.28620476166 21560.365295728938 19470.463327882153 22636.316339149642 17570.417445816947 17353.565121875712 16930.896010763197 16565.264490293222 18091.786814848958 15701.464301500253 1.2237894400031002 1.3731436050629287 1.2400412441801225 1.4416691274448061 1.1190304998584188 1.105219538041277 1.0783004492864703 1.0550139892819064 1.152235642959766 1.0 13.938611489112409 -6.395817453463195 6.1794765097013045 1.0849176026688476 1.3170529894832292 0.7406961278863778 0.06826740630482894 0.11596603138150006 5.349311915511788 0.019911064235926673 0.022565155987378686 4.0195973065077886e-07 6.395817453463195 0.23213538681438162 ATVTPS(ph)PVKGK ddPTM_A459_Selumetinib_30min_R2 3 ATVTPSPVKGK 11 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 ATVTPS(1)PVKGK;ATVT(0.003)PS(0.997)PVKGK;ATVT(0.025)PS(0.975)PVKGK 156.0 0.002571 3344856000.0 1112984.0 974100.0 1165134.0 1106295.0 934765.0 644001.0 658487.0 685576.0 592302.0 893660.0 True False 1051128.8049079604 1048810.3377748337 1090170.5469419842 955615.7125346765 817331.4637948724 732706.2920909814 689107.9502672364 687570.9126567825 710778.9503006267 867857.7137924724 1.2111764269682033 1.2085049439632356 1.2561627667950563 1.1011202612450242 0.9417804909784069 0.8442700692134318 0.7940333297907637 0.7922622588121615 0.8190040129903052 1.0 19.72709900508739 -6.2522861302087245 1.7882639151170945 0.832594071253875 1.2257958607658668 0.8870322180204223 0.05915786930034347 0.10028434063023922 0.6323664824158696 0.019996257202885902 0.026681490012366155 5.593889327309517e-07 6.2522861302087245 0.3932017895119918 AVAAPRPDR ddPTM_A459_Selumetinib_30min_R1 1 AVAAPRPDR 9 1 O75534;O75534-4;O75534-2;O75534-3;E9PLT0 O75534 CSDE1 Cold shock domain-containing protein E1 0 112.41 0.027361 1489900.0 825.1 835.9 1269.9 1053.1 1109.7 1012.1 877.44 781.88 534.77 773.86 False True 844.3232246348798 738.0324394006324 1097.454555061388 869.1958541352997 1009.3278309334481 1001.9191929132744 811.2539943690032 761.1420024958259 907.4656319445456 873.1924690347303 0.9669382805926351 0.8452116407010354 1.2568300735284261 0.9954229851479953 1.155905332130508 1.1474207903108062 0.9290666412478374 0.8716772412584244 1.0392504105626363 1.0 9.770155877440693 -7.285141867290143 24.450417637931416 0.9493049928885176 1.0616617043911747 0.15510259229611634 0.1147317432865284 1122.7713030303414 1158194.6860705835 0.04938019693881015 0.03331557286982042 5.1863059460314683e-08 7.285141867290143 0.11235671150265714 AVAEEDNGS(ph)IGEETDSSPGR ddPTM_A459_Selumetinib_30min_R2 1 AVAEEDNGSIGEETDSSPGR 20 0 E9PNJ4;G0XQ39;Q13586 E9PNJ4 STIM1 Stromal interaction molecule 1 1 AVAEEDNGS(1)IGEETDSSPGR 260.24 1.3642000000000002e-47 3441800.0 7661.7 4081.8 6788.6 7849.4 5833.8 5441.7 8458.3 7763.1 7726.3 5543.7 True False 7235.893386215187 4394.860934944367 6351.82886686882 6780.2981790297345 5100.905889166283 6191.24478016571 8851.62770980349 7785.689335749613 9271.775890859282 5383.638976737598 1.3440524926506174 0.8163364880026901 1.1798393046626485 1.259426608717082 0.9474829035169355 1.1500111368755839 1.6441718599725719 1.4461759730530113 1.7222135308333464 1.0 12.394365951680575 -7.167121623692936 6.250760595197011 1.4890973793045679 1.1010112855919474 0.3414977177275056 0.22703628030364828 0.23354792494598245 12.846186618641894 0.0822215919277849 0.0634406068344322 6.805787366751025e-08 7.167121623692936 -0.3880860937126205 AVAEEDNGSIGEETDSS(ph)PGRK ddPTM_A459_Selumetinib_30min_R2 2 AVAEEDNGSIGEETDSSPGRK 21 1 E9PNJ4;G0XQ39;Q13586 E9PNJ4 STIM1 Stromal interaction molecule 1 1 AVAEEDNGSIGEET(0.001)DS(0.167)S(0.831)PGRK;AVAEEDNGSIGEET(0.005)DS(0.239)S(0.757)PGRK 133.53 2.2045e-05 9573100.0 36409.0 17089.6 32536.0 33948.0 25176.0 19332.800000000003 39959.0 30719.0 32215.0 24532.0 True False 34385.53353677499 18400.317368275075 30442.669182518326 29324.223836433535 22013.16580370435 21995.717714314957 41817.17267725638 30808.387204195773 38658.9001623069 23823.697418209293 1.443333204462751 0.7723535539118735 1.2778314233981969 1.2308846658713855 0.9240029126158608 0.9232705288433882 1.7552763512389995 1.2931824419767788 1.6227078225380136 1.0 14.540109715209825 -7.245885654477299 24.994918663454985 1.4422235514943171 1.0872773391407675 0.26497088848555894 0.26168590414710713 977.1941612382928 1570358.075991805 0.0947763422920037 0.07315211534405387 5.67694054069038e-08 7.245885654477299 -0.3549462123535496 AVAGVMIT(ph)ASHNR ddPTM_A459_Selumetinib_30min_R1 1 AVAGVMITASHNR 13 0 Q6PCE3 Q6PCE3 PGM2L1 Glucose 1,6-bisphosphate synthase 1 AVAGVMIT(0.87)AS(0.13)HNR 156.96 0.00049493 11236000.0 4865.7 7014.4 5825.7 6787.7 6029.5 5845.2 6048.7 5833.5 3256.0 4700.9 True False 4979.061342995919 6193.150787093907 5034.601938279489 5602.355615909386 5484.132789594687 5786.402595016963 5592.441689163689 5678.776630121501 5525.194191168993 5304.306305643613 0.9386828467463043 1.1675703532627049 0.9491536966714824 1.0561900639012227 1.0339019795594655 1.0908877168085889 1.0543210302944814 1.0705974170608252 1.0416431240575912 1.0 12.37294837324862 -6.320417202430695 2.7512577294412077 1.055736101409045 1.0314824853851319 0.023515589860330977 0.06282817523561349 1.261595667512184 18.831948701274627 0.019500348059314894 0.023529692807144963 4.781705199275736e-07 6.320417202430695 -0.02425361602391307 AVAGVMITAS(ph)HNR ddPTM_A459_Selumetinib_30min_R1 3 AVAGVMITASHNR 13 0 Q6PCE3 Q6PCE3 PGM2L1 Glucose 1,6-bisphosphate synthase 1 AVAGVMIT(0.003)AS(0.997)HNR;AVAGVMIT(0.261)AS(0.739)HNR;AVAGVMIT(0.083)AS(0.917)HNR 156.72 0.00024154 108915000.0 12120.099999999999 16421.199999999997 13175.0 14868.8 13322.099999999999 13957.5 14157.0 12191.099999999999 7447.94 11528.1 True False 12402.47474839075 14498.598269991238 11385.907365094714 12272.243201943726 12117.118407207783 13817.100222396039 13089.126092133914 11867.752425726272 12638.610203985003 13007.843928203136 0.9534612205409502 1.1146042610917173 0.8753108837974448 0.9434494501687165 0.9315239692364302 1.0622129461776753 1.0062487038112862 0.9123535376985145 0.9716145330266783 1.0 13.667094232315023 -8.655365271721035 0.0022361839320807512 0.502477809961297 1.4462145916016176 0.0 0.06784042248356804 833932.8979789419 1077.6571645165604 228230.17099524356 226558.2330241275 2.2112341263143533e-09 8.655365271721035 0.9437367816403206 AVAGVMITAS(ph)HNR ddPTM_A459_Selumetinib_30min_R2 10 AVAGVMITASHNR 13 0 Q6PCE3 Q6PCE3 PGM2L1 Glucose 1,6-bisphosphate synthase 1 AVAGVMIT(0.197)AS(0.803)HNR;AVAGVMIT(0.187)AS(0.813)HNR;AVAGVMIT(0.025)AS(0.975)HNR;AVAGVMIT(0.014)AS(0.986)HNR;AVAGVMIT(0.002)AS(0.998)HNR;AVAGVMIT(0.049)AS(0.951)HNR;AVAGVMIT(0.017)AS(0.983)HNR;AVAGVMIT(0.003)AS(0.997)HNR;AVAGVMIT(0.088)AS(0.912)HNR;AVAGVMIT(0.015)AS(0.985)HNR 202.32 5.187100000000001e-05 196429000.0 546919.0 369612.0 521196.0 546389.0 503372.0 412705.0 351169.0 392344.0 299295.0 442665.0 True False 516523.43147022533 397960.0519101028 487662.8167952988 471969.8756264009 440133.90915722365 469551.3675870202 367499.0543281722 393485.6560839544 359162.36300101393 429884.1112682047 1.2015411082452554 0.9257379872358564 1.1344053060175698 1.0979002555689688 1.0238431652167392 1.0922743020247778 0.8548793609608184 0.9153296103992518 0.8354864801619349 1.0 18.713588263013023 -7.257448657923833 24.8847121304735 0.8943679935301487 1.073136054540668 0.5490729223446666 0.07874083910221884 233.37431615354456 1455244.602275152 0.028904311510474446 0.021547555130910653 5.527787533092095e-08 7.257448657923833 0.17876806101051934 AVAHHTDCTFIR ddPTM_A459_Selumetinib_30min_R2 1 AVAHHTDCTFIR 12 0 P62195-2;P62195;J3QSA9;J3QQM1;J3QRW1;J3QLH6;J3KRP2;J3QRR3 P62195-2 PSMC5 26S protease regulatory subunit 8 0 105.46 0.0052527 3044800.0 9654.8 5426.8 8094.9 9848.9 11951.0 9217.5 10223.0 8520.2 8220.5 10281.0 False True 9118.224867226649 5843.018110087731 7574.082947060724 8507.462829699849 10449.608536704429 10487.126956865943 10698.389756490194 8544.992371404958 9864.829699961005 9984.160816754018 0.9132690302750055 0.5852287655746488 0.7586098707816245 0.8520959333331068 1.0466186120689644 1.0503764061239795 1.0715362014740044 0.8558548413068378 0.9880479572611883 1.0 13.285425456809463 -6.002808825439304 2.97703618966752 1.000094046851166 0.7363653471112489 0.5963211960507813 0.09279247769868819 0.17298907296741006 3.1308610410653737 0.028311831533952916 0.041864923714153277 9.93553310061996e-07 6.002808825439304 -0.2637286997399172 AVAS(ph)PEATVSQTDENK ddPTM_A459_Selumetinib_30min_R1 2 AVASPEATVSQTDENK 16 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 AVAS(1)PEATVSQTDENK;AVAS(1)PEATVSQTDENK 317.7 2.5742999999999987e-117 103964000.0 7366.5 8565.3 9704.7 9427.0 8433.6 7602.799999999999 8240.5 7139.5 5051.6 7177.9 True False 7538.125117286203 7562.470694100057 8386.855044101305 7780.751416706358 7670.782369073015 7526.322734790077 7618.912450535388 6950.137267635634 8572.196245733807 8099.253383666804 0.9307185193746143 0.9337244232105097 1.035509650928379 0.9606751447481879 0.947097467594006 0.9292613007969208 0.9406931836334339 0.8581207351348568 1.0583933900649105 1.0 12.983573206322683 -6.179112196126118 5.101466127777089 0.946465452993465 0.9684028591848032 0.0 0.05539305474753573 0.9998172874663277 45.12920167383776 0.016222040731764854 0.02107764417546814 6.620454480398602e-07 6.179112196126118 0.021937406191338216 AVAS(ph)PEATVSQTDENK ddPTM_A459_Selumetinib_30min_R2 4 AVASPEATVSQTDENK 16 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 AVAS(1)PEATVSQTDENK;AVAS(0.992)PEAT(0.007)VS(0.001)QTDENK;AVAS(1)PEATVSQTDENK;AVAS(1)PEATVSQTDENK 319.8 2.0133999999999993e-117 130018000.0 221460.0 221974.0 221180.0 229423.0 222505.0 184878.0 208133.0 199552.0 171982.0 222911.0 True False 209152.13977462103 238998.69204109485 206949.51960257598 198175.19162324982 194551.93268006158 210343.26634461238 217811.59690771534 200132.66328238783 206383.205578577 216474.98023766736 0.9661723472384356 1.1040476445762866 0.9559974061453503 0.9154646481809295 0.8987271067837193 0.9716747224722091 1.0061744626033942 0.9245071327072656 0.9533813346558082 1.0 17.723840765102864 -5.402704152101351 9.183513427933633 0.9493449920252385 1.0348802749117656 0.3457151285052287 0.04488301858337397 0.3291595038634626 23.47952950666275 0.01155448920280665 0.024094941133569032 3.9563604148141635e-06 5.402704152101351 0.08553528288652712 AVAS(ph)SPAATNSEVK ddPTM_A459_Selumetinib_30min_R2 1 AVASSPAATNSEVK 14 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 AVAS(0.909)S(0.089)PAAT(0.001)NSEVK 137.8 0.00058404 3096900.0 10684.0 9863.4 11514.0 12080.0 9605.3 8944.8 8816.0 12273.0 8331.4 10514.0 True False 10090.22605144069 10619.891064170288 10773.201775495332 10434.68316083768 8398.59634152849 10176.865007190077 9225.961468572594 12308.712398095478 9997.912798765907 10210.433501347317 0.9882269984040575 1.0401018784137754 1.0551169814752484 1.0219627951605357 0.8225504177095178 0.9967123340891637 0.9035817595163989 1.2055034094753452 0.9791859275560272 1.0 13.317756499141009 -9.769237776056595 7.117270045532146 0.9999847401988444 1.0024810906452783 0.0 0.09419060820723275 0.0 0.0 0.09288001575254323 0.02252671267392753 1.7012268323561057e-10 9.769237776056595 0.002496350446433926 AVASS(ph)PAATNSEVK ddPTM_A459_Selumetinib_30min_R2 1 AVASSPAATNSEVK 14 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 AVAS(0.128)S(0.861)PAAT(0.011)NSEVK 107.17 0.0052911 3886300.0 27606.0 24668.0 26662.0 30123.0 34738.0 22214.0 25759.0 25253.0 23146.0 34270.0 True False 26071.769035573885 26559.956279878406 24946.595947390702 26020.1954349266 30373.901878339737 25273.77686138543 26956.84454049017 25326.4820491408 27775.84675327506 33280.536055846715 0.7833939030255976 0.7980627546175706 0.749585160092639 0.781844240467256 0.9126626394289601 0.759416159011818 0.8099882915123418 0.7609998230389516 0.8345973366133749 1.0 15.022391050975669 -14.522878745080465 0.3810834419089444 3.866033090748473 0.7937904839220864 0.6489833347694998 0.04460354164588356 382.276776885083 2.85259386637817 905.6567514761265 0.030198252643752074 3.000000001380669e-15 14.522878745080465 -3.0722426068263866 AVCST(ph)YLQSR ddPTM_A459_Selumetinib_30min_R1 1 AVCSTYLQSR 10 0 Q5SQL3;J3KP92;Q86Z02;H7BXX9;Q9H2X6-2;Q86Z02-2;Q9H2X6-3;Q9H2X6 Q5SQL3;Q9H2X6-3 HIPK1;HIPK2 Homeodomain-interacting protein kinase 1;Homeodomain-interacting protein kinase 2 1 AVCS(0.009)T(0.674)Y(0.317)LQSR 155.33 0.0012328 21911000.0 979.9 920.84 970.81 1088.0 995.21 893.47 1085.1 1078.5 609.74 871.81 True False 1002.729763446514 813.0276247130986 838.9793342776168 898.0012242894367 905.1934312185966 884.4825030058522 1003.2500333809785 1049.8946765382766 1034.6842463523892 983.7153056485267 1.0193292283741093 0.8264867081407256 0.8528680294595081 0.9128669841092063 0.9201782528145543 0.8991244701867741 1.0198581110004925 1.067274922439191 1.0518126945989323 1.0 9.942097039326015 -7.313283574162905 3.812355226697091 1.04443819834035 0.8995152885731431 0.6154589163683004 0.05013549967282602 0.14861312890040348 4.48121309108531 0.021853297061599802 0.014606240078037545 4.8608970800277125e-08 7.313283574162905 -0.1449229097672068 AVDFFGAFYMS(ph)NTT(ph)DVELAGLDGDK ddPTM_A459_Selumetinib_30min_R2 1 AVDFFGAFYMSNTTDVELAGLDGDK 25 0 G5EA31;P53992-2;P53992 G5EA31 SEC24C Protein transport protein Sec24C 2 AVDFFGAFY(0.039)MS(0.748)NT(0.258)T(0.954)DVELAGLDGDK 42.209 0.046495 20640000.0 13313.0 17806.0 33426.0 39024.0 66594.0 44031.0 16404.0 28171.0 38959.0 34042.0 True False 12573.11675616154 19171.662944686017 31275.407551477074 33708.863879845165 58227.86636208637 50095.87057637805 17166.818503909355 28252.972946039907 46751.88860541097 33059.119008261885 0.3803221965176798 0.5799205641231631 0.9460447976142667 1.0196540286333977 1.7613254106237528 1.5153419715709444 0.5192763454954488 0.8546196569539296 1.4141903961121012 1.0 15.01276065834341 -5.2875526933017785 1.848700870202819 1.161029705909431 0.38416967890827686 0.40011281293237455 0.3315771036998275 0.459618056037782 2.788000397973117 0.10510754408661364 0.4279350927457824 5.1575958374719325e-06 5.2875526933017785 -0.7768600270011541 AVDITT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AVDITTPK 8 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 AVDIT(0.082)T(0.918)PK 118.03 0.020036 179680000.0 17363.0 20436.0 22733.0 23041.0 16239.0 15964.0 17521.0 16279.0 10826.0 15227.0 True False 17767.524117483226 18043.343619561354 19645.983463430595 19017.32188313686 14770.185317228306 15803.416654152265 16199.376863761969 15847.228038355695 18370.931300244312 17181.53377354023 1.0341058226620854 1.0501590752828085 1.143435954110549 1.106846579228204 0.8596546450337611 0.9197907976347092 0.9428364823115619 0.9223407087649309 1.069225340553459 1.0 14.068571209315229 -6.243723641597454 24.972573172586657 0.9463255936991402 1.0855169622726155 0.5441010286698309 0.05872950032561145 617.2331164401102 870067.8772169752 0.017772326352864253 0.022893695652972838 5.705272053561785e-07 6.243723641597454 0.13919136857347536 AVDITT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AVDITTPK 8 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 AVDIT(0.034)T(0.966)PK 131.52 0.0082976 78118000.0 467490.0 440550.0 459070.0 451210.0 379280.0 335250.0 398790.0 321550.0 267880.0 374780.0 True False 441508.77731074597 474338.76840848126 429533.9359976247 389754.41961933515 331631.455593779 381427.64440350473 417334.52518739353 322485.6572645316 321463.4851925746 363959.1276046169 1.21307241342323 1.3032748251989825 1.180170803311311 1.0708741450846115 0.9111777406886282 1.0479958200632478 1.14665217474848 0.8860490994880623 0.8832406190999365 1.0 18.473416920154875 -5.77238643627265 2.3498649915828107 0.9852498952079726 1.256201185011946 0.676668824647368 0.07876924562432235 0.18118230356421197 2.0409063265707204 0.025167570860071566 0.046430505802010844 1.6889374422473198e-06 5.77238643627265 0.27095128980397354 AVDS(ph)SSEEIEVEVPVVDR ddPTM_A459_Selumetinib_30min_R1 1 AVDSSSEEIEVEVPVVDR 18 0 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 AVDS(0.978)S(0.019)S(0.003)EEIEVEVPVVDR 143.39 0.00010356 0.0 386.87 322.12 262.8 332.25 491.62 269.15 543.82 299.81 178.44 371.35 True False 395.88331828202143 284.4060406504746 227.11320345706966 274.22877460493135 447.1530578025607 266.44259536864723 502.79921956800615 291.8580648798711 302.799647258045 419.0163897553137 0.9447919650904326 0.6787468166019822 0.5420150834426628 0.6544583489086628 1.0671493257427889 0.6358763090967335 1.1999511996693442 0.696531381625198 0.7226439219593919 1.0 8.710862865575875 -6.2183034594776485 24.997358521136935 0.8749409162690096 0.6914855576238849 0.17855304728563948 0.18932264838493756 840.6569578418809 487162.2098667488 0.05498600687733867 0.07098621546429527 6.049180458437789e-07 6.2183034594776485 -0.18345535864512474 AVDS(ph)SSEEIEVEVPVVDRR ddPTM_A459_Selumetinib_30min_R1 5 AVDSSSEEIEVEVPVVDRR 19 1 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 AVDS(0.977)S(0.02)S(0.004)EEIEVEVPVVDRR;AVDS(0.944)S(0.045)S(0.012)EEIEVEVPVVDRR;AVDS(0.978)S(0.021)S(0.002)EEIEVEVPVVDRR;AVDS(0.947)S(0.04)S(0.013)EEIEVEVPVVDRR;AVDS(0.93)S(0.035)S(0.035)EEIEVEVPVVDRR 269.39 6.4949e-59 30281200.0 4790.39 5411.169999999999 6148.539999999999 6723.83 6656.67 5038.24 6228.9400000000005 4875.29 2646.3599999999997 4913.67 True False 4901.996766523674 4777.627700815315 5313.602039512672 5549.639312421 6054.575373830544 4987.55987995591 5759.086040851633 4745.98147202624 4490.67963751289 5544.3874076989205 0.8841367686025646 0.861705243428898 0.9583749562907922 1.0009472470691327 1.0920188162578932 0.8995691522259427 1.0387235987251868 0.8559974480563866 0.8099505513047563 1.0 12.436812352317398 -10.576657276223209 15.183968632554421 0.9999999998154953 0.938576700233261 0.04973686083322548 0.08462533616487848 0.0 0.0 0.08681202842358586 0.021055009574386305 2.6505910291429593e-11 10.576657276223209 -0.06142329958223425 AVDS(ph)SSEEIEVEVPVVDRR ddPTM_A459_Selumetinib_30min_R2 3 AVDSSSEEIEVEVPVVDRR 19 1 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 AVDS(0.98)S(0.019)S(0.001)EEIEVEVPVVDRR;AVDS(0.68)S(0.08)S(0.241)EEIEVEVPVVDRR;AVDS(0.333)S(0.333)S(0.333)EEIEVEVPVVDRR 212.26 5.0779e-17 9491200.0 12478.599999999999 11417.400000000001 15018.5 13461.4 14752.9 12278.0 12769.400000000001 10988.599999999999 8301.64 15241.8 True False 11785.089367793687 12293.077867272725 14052.22606090642 11627.934097789754 12899.508809400611 13969.183051413087 13363.202402086074 11020.575006739342 9962.199967202028 14801.72963104771 0.7961967730496577 0.8305163094917701 0.9493637845830427 0.7855794145435079 0.8714865850773917 0.9437534260936441 0.9028135721419867 0.7445464335210448 0.6730429629187109 1.0 13.853478148939866 -10.630212228902868 4.551175351323543 1.0000122640364448 0.8388222738346763 0.26294719187675386 0.08335661595727381 1.2521713721854037e-05 2.455950523187226e-06 0.08564565457471097 0.020770324944743783 2.3430835289095796e-11 10.630212228902868 -0.1611899902017685 AVEFS(ph)SGAKSPSK ddPTM_A459_Selumetinib_30min_R1 1 AVEFSSGAKSPSK 13 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 AVEFS(0.934)S(0.064)GAKS(0.001)PS(0.001)K 143.94 0.0033029000000000005 41909000.0 3927.8 4015.3 4997.3 5542.7 3615.2 4218.9 3958.8 4023.8 2460.4 3369.8 True False 4019.3100978316347 3545.186809337672 4318.694108204008 4574.771494364945 3288.2057983153986 4176.461696454709 3660.1845287518327 3917.0757528555596 4175.119099493916 3802.346654631632 1.0570604058248396 0.932368121938405 1.1357970486313798 1.2031442448290253 0.8647832764827059 1.0983905666168992 0.9626120028518094 1.0301732347533794 1.0980374696789443 1.0 11.892674351135607 -6.249953797011052 24.999813804867244 1.012658266850003 1.0752338833257424 0.135274461747664 0.08958133347799967 1921.2899179185858 4181930.1190291247 0.027031667844197773 0.034584904507951396 5.624011537933383e-07 6.249953797011052 0.06257561647573939 AVEFSS(ph)GAKSPSK ddPTM_A459_Selumetinib_30min_R1 1 AVEFSSGAKSPSK 13 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 AVEFS(0.045)S(0.952)GAKS(0.003)PS(0.001)K 135.81 0.0053507 40852000.0 4162.8 4676.7 5543.1 5974.5 4735.1 4892.9 4855.5 4521.9 2815.9 3973.4 True False 4259.785140601233 4129.149789861154 4790.377466068808 4931.165730254815 4306.811041049806 4843.681868397748 4489.2457258145205 4401.964522798733 4778.376634801219 4483.4245941935205 0.9501186093590327 0.9209812060202401 1.0684639309586743 1.0998658785610365 0.9606074442798822 1.0803531467153025 1.0012983672410904 0.9818308371907746 1.0657872201061862 1.0 12.130385418208798 -5.25342953131525 24.91952879145773 1.032092005602036 0.9355498972060773 0.43529269869782383 0.04406766323420804 527.5280660730044 1641189.1511322362 0.01115378930230724 0.028435365199318604 5.579181226714476e-06 5.25342953131525 -0.09654210839595867 AVEFSSGAKSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 AVEFSSGAKSPSK 13 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 AVEFS(0.054)S(0.004)GAKS(0.095)PS(0.847)K 120.7 0.014161000000000003 9178200.0 35168.0 35415.0 33113.0 33069.0 31267.0 22545.0 27447.0 23903.0 18980.0 32502.0 True False 33213.50334865838 38131.21662282687 30982.545630708446 28564.945152793127 27338.959929473454 25650.369106866598 28723.3398851987 23972.55377264534 22776.530345509393 31563.58280966242 1.0522729168277714 1.2080763091049957 0.9815915327972177 0.904996917651841 0.8661551540056568 0.8126570821045817 0.9100151924579916 0.7595004001037147 0.7216078885232545 1.0 14.945973355761343 -5.645085935649419 1.8310947176733536 0.8361156150285285 1.133298835969986 0.6373391468058178 0.08312184995761704 0.20666417244011415 1.3895667291658342 0.02474986973195347 0.0581332082195852 2.264196237368483e-06 5.645085935649419 0.29718322094145755 AVFHEEEQR ddPTM_A459_Selumetinib_30min_R1 1 AVFHEEEQR 9 0 A0A2R8Y611;O14617-3;O14617-2;O14617;O14617-5;O14617-4 A0A2R8Y611 AP3D1 AP-3 complex subunit delta-1 0 143.37 0.0028646 2236900.0 2553.7 2935.2 3100.8 2749.2 3187.9 2776.2 3053.6 2240.4 1213.5 2189.0 False True 2613.1962413647966 2591.545419462539 2679.7283914751947 2269.1038288754785 2899.5550078694564 2748.273948587917 2823.2644935325347 2180.977314155176 2059.2208694666983 2469.9794726656314 1.0579829793259796 1.0492173915379597 1.0849192963467018 0.9186731525451239 1.1739186661094887 1.112670764677225 1.143031561507527 0.8829941051297236 0.8336995882983442 1.0 11.270283336671815 -7.772692087597455 24.999255750135998 0.8937600497255428 1.0754092575323582 0.5216671255198162 0.07504781786834712 171.64446965297643 381322.8447024426 0.0408899754652022 0.019924810732644984 1.687749206213985e-08 7.772692087597455 0.18164920780681537 AVFHEEEQR ddPTM_A459_Selumetinib_30min_R2 1 AVFHEEEQR 9 0 A0A2R8Y611;O14617-3;O14617-2;O14617;O14617-5;O14617-4 A0A2R8Y611 AP3D1 AP-3 complex subunit delta-1 0 138.06 0.0027116 0.0 26439.0 23686.0 27206.0 32504.0 28846.0 21281.0 25119.0 24545.0 21757.0 24661.0 False True 24969.626223702748 25502.640037506055 25455.59557965312 28076.89912747251 25222.107593488057 24212.264580316154 26287.083272354223 24616.421886356497 26109.007941372394 23948.97285302702 1.042617834883333 1.0648740634520641 1.0629097012165043 1.1723633952812194 1.0531603066350348 1.01099386303141 1.0976288391855469 1.0278696308783497 1.0901932246364527 1.0 14.5476761611217 -6.489440950077934 24.996459699159463 1.048317144792034 1.0863501482438132 0.1642096656869383 0.04318841813197234 1249.479499423446 934049.6927371657 0.013372594434772445 0.015154257498009418 3.2401047432450687e-07 6.489440950077934 0.03803300345177907 AVFPS(ph)IVGRPR ddPTM_A459_Selumetinib_30min_R1 2 AVFPSIVGRPR 11 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I 1 AVFPS(1)IVGRPR;AVFPS(1)IVGRPR 153.49 0.00030776 402650000.0 4383.1 7815.8 7631.5 8944.5 7899.299999999999 5968.5 7360.5 5806.7 2706.7 5282.4 True False 4485.217701972052 6900.72250253316 6595.1842168288695 7382.510984059623 7184.809709734687 5908.462308964408 6805.2915590274515 5652.687453180171 4593.072210453659 5960.447494933269 0.7524968059503504 1.157752418488575 1.1064914542800963 1.2385833430015434 1.2054144786682877 0.9912783082120845 1.1417417173479592 0.9483662859181778 0.7705918413605758 1.0 12.54120493321622 -7.914609075639205 4.764469263826747 0.8770296555342768 1.094767541648876 0.2603896452266078 0.13927928568693632 0.25232766784191935 9.994480239158078 0.08050425596838878 0.03671728760606126 1.2172812270375685e-08 7.914609075639205 0.2177378861145992 AVFPS(ph)IVGRPR ddPTM_A459_Selumetinib_30min_R2 2 AVFPSIVGRPR 11 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I 1 AVFPS(1)IVGRPR;AVFPS(1)IVGRPR 129.54 0.0014112 274580000.0 64815.0 65884.0 80252.0 68693.0 73376.0 44530.0 48047.0 51018.0 44622.0 66268.0 True False 61212.84177500263 70937.09094955039 75088.67369177114 59336.89489796549 64157.85089023711 50663.60329690704 50281.28070332435 51166.453933515426 53547.64684285145 64354.67065505838 0.9511794738738393 1.1022834897217304 1.1667944677123299 0.922029346028539 0.9969416397781565 0.7872560418879992 0.7813151740428054 0.7950697814579472 0.8320708706578164 1.0 15.973757237962191 -6.40538654391705 1.658225119231471 0.8246237953223613 1.0642874552720054 0.5161275980420801 0.0895699963171187 0.2655175752211788 1.459495995335858 0.03302215647767984 0.03961903118836073 3.9319995194520257e-07 6.40538654391705 0.23966365994964411 AVFPSIVGR ddPTM_A459_Selumetinib_30min_R1 1 AVFPSIVGR 9 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I 0 143.89 0.027623 25035000.0 2133.4 2600.8 2289.0 2221.7 2499.3 2781.2 1964.2 2143.2 1751.9 2672.0 False True 2183.1040691262315 2296.2971269208824 1978.166372576987 1833.7218014741197 2273.238756287255 2753.2236531275566 1816.0388126135076 2086.3553739052722 2972.8463462865325 3014.9772274840407 0.7240864206951253 0.7616300070157122 0.6561132052820648 0.6082041962898462 0.7539820651263237 0.913182238336535 0.6023391473934842 0.6919970588455517 0.9860261361799187 1.0 11.55793138996492 -8.265269717184397 23.944147165472714 0.9930131729985868 0.7143351244775428 0.6362574918218131 0.08440215605581396 125.21396514420114 782704.6311846923 0.07471057811466088 0.022227982565819156 5.429130523736752e-09 8.265269717184397 -0.27867804852104405 AVFPSIVGRPR ddPTM_A459_Selumetinib_30min_R1 2 AVFPSIVGRPR 11 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I 0 ; 219.72 3.7191e-05 288120000.0 8147.3 7858.5 10052.099999999999 10553.599999999999 9831.0 8602.8 7667.2 8080.9 5520.9 7399.8 False True 8337.116238113877 6938.423166682468 8687.08003223291 8710.611875607536 8941.787785804026 8516.263642717433 7088.856931101869 7866.568281537474 9368.564069417964 8349.63641015584 0.9985005129053602 0.8309850663967975 1.0404141696118205 1.0432324771666266 1.0709194205064956 1.0199562261608088 0.8490018706059514 0.9421450102868193 1.1220325783315284 1.0 13.027497660609756 -5.282679610897057 24.957077448684327 1.0067271533156827 0.9147427608606366 0.18843014814799086 0.07948744740344423 1239.9382651724727 1456914.417438139 0.02181779831414892 0.0454822976321065 5.215793503820009e-06 5.282679610897057 -0.0919843924550462 AVFPSIVGRPR ddPTM_A459_Selumetinib_30min_R2 1 AVFPSIVGRPR 11 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63267-2;F8WCH0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member I 0 181.87 0.00011178 14805000.0 34483.0 37092.0 38969.0 44805.0 43850.0 25380.0 28797.0 27015.0 24165.0 37099.0 False True 32566.572906386104 39936.837130421976 36461.776966239144 38702.481707063904 38341.17097602618 28875.864623298898 30136.117560172974 27093.609177425995 28998.675226513948 36027.855475221986 0.903927599265064 1.1084988713216188 1.012044055503542 1.074237730682621 1.0642090812869827 0.8014871893543083 0.8364671491729218 0.7520183707870016 0.8048959574198823 1.0 15.136825158781788 -6.762152302657012 24.999787407754013 0.8233181955805557 1.0379740556707988 0.5947971261108533 0.07931387757296246 11.70764736391026 410536.4911674655 0.025627585286763666 0.023941377143440808 1.7292098365710837e-07 6.762152302657012 0.21465586009024307 AVFVDLEPT(ph)VIDEVR ddPTM_A459_Selumetinib_30min_R1 2 AVFVDLEPTVIDEVR 15 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 AVFVDLEPT(1)VIDEVR;AVFVDLEPT(1)VIDEVR 186.85 6.3628e-14 3157800.0 1777.75 2065.62 2239.68 2269.9700000000003 2294.51 1693.71 1877.0900000000001 2508.92 1061.38 1667.48 True False 1819.168116100663 1823.7762501193138 1935.5437576816196 1873.5623521142406 2086.9719756286436 1676.6728151656382 1735.4995900461704 2442.3752914792904 1801.084339871912 1881.5173006306472 0.9668622847586434 0.9693114432208624 1.0287143025646714 0.995772056672697 1.1091962720348796 0.8911280351255079 0.9223936391466958 1.2980881391102035 0.957251011865915 1.0 10.877680839770399 AVFVDLEPTVIDEIR ddPTM_A459_Selumetinib_30min_R1 1 AVFVDLEPTVIDEIR 15 0 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 0 147.58 0.0044508 0.0 447.56 497.24 504.44 538.73 595.53 400.53 451.85 428.63 421.19 419.11 False True 457.98727719983873 439.02290963939555 435.9398186905791 444.65091871456656 541.6644166493611 396.5010318521427 417.7665907134781 417.26134001353904 714.7286674995297 472.90685097710923 0.9684513477729408 0.9283496501103685 0.9218302035376529 0.9402505330507247 1.1453934649713502 0.8384336810365539 0.8834014348709442 0.8823330411716457 1.511351899476131 1.0 8.88541223197033 -8.235775982060234 24.97700305997906 1.2556760702008842 0.9394329517009601 0.457182534224181 0.13821591388890495 534.9102277252363 520605.13378127635 0.08752460457601888 0.03305693765639229 5.81064064912737e-09 8.235775982060234 -0.31624311849992415 AVFVDLEPTVIDEVR ddPTM_A459_Selumetinib_30min_R1 5 AVFVDLEPTVIDEVR 15 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 ;;;; 326.79 5.411799999999997e-110 62931200.0 8170.4400000000005 8433.72 9336.51 9708.470000000001 9035.689999999999 8624.92 8417.83 7670.7300000000005 6622.46 7236.78 False True 8360.795355091275 7446.296141669939 8068.663223778407 8013.067965052641 8218.413434880638 8538.161135600792 7782.866305866185 7467.277322357399 11237.830934658788 8165.691205206573 1.0238931579680972 0.911900285541298 0.9881176033981913 0.9813092074732612 1.0064565544237638 1.0456140112372516 0.9531178819135002 0.9144697166109031 1.3762253129892263 1.0 12.995359296121734 -8.237777787689176 24.96408555247363 1.1881127680543289 0.9787050214965449 0.44668966236671126 0.09348841412826059 547.8255801688113 577983.5227642705 0.05778436818385987 0.02181534499973055 5.783919133069585e-09 8.237777787689176 -0.20940774655778394 AVFVDLEPTVIDEVR ddPTM_A459_Selumetinib_30min_R2 3 AVFVDLEPTVIDEVR 15 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 ;; 238.01 8.0073e-19 53519000.0 54408.0 51953.0 61831.0 62156.0 64809.0 49878.0 48921.0 55526.0 44780.0 50663.0 False True 51384.22117248079 55937.628044775505 57852.860776502675 53690.245574919434 56667.11402018886 56748.24175259669 51195.92343512245 55687.57146717586 53737.25125774028 49200.2275517176 1.0443899089382758 1.1369384010668604 1.175865715573972 1.0912601068456864 1.1517652832117966 1.1534142132360032 1.040562736855374 1.1318559738090435 1.0922155024842826 1.0 15.586377367613464 -9.487470272832972 0.5325135114943136 0.9901537355145875 1.1234209047674597 0.3955618145323436 0.04286348312289962 4.068051646356265 1.4385256929756782 0.129246643148099 0.02000744878692214 3.254840619020678e-10 9.487470272832972 0.1332671692528722 AVFVDLEPTVIDEVRT(ph)GTYR ddPTM_A459_Selumetinib_30min_R1 2 AVFVDLEPTVIDEVRTGTYR 20 1 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 AVFVDLEPTVIDEVRT(0.808)GT(0.056)Y(0.136)R;AVFVDLEPTVIDEVRT(0.79)GT(0.208)Y(0.002)R 115.99 0.00037193 6158300.0 1092.29 1560.7 2301.36 2616.5 1958.1599999999999 1733.28 1563.53 1489.51 711.75 857.77 True False 1117.7382317736435 1377.9725184502538 1988.847952465606 2159.5773927879713 1781.0447737412273 1715.8447768923224 1445.5916732947746 1450.0033561896419 1207.7877658367725 967.8731348873449 1.1548396080894858 1.423711919238922 2.0548643006783083 2.2312608077910276 1.8401634569064995 1.7727992595765532 1.493575574306062 1.498133695340572 1.2478781797961076 1.0 9.918674146712974 -8.134832024609278 1.0586015887989604 1.0202549480860175 1.7660459267383455 0.4180522695146497 0.2874527966335475 0.5309374831512346 1.1476985845512713 0.3001012635943023 0.10443791425007691 7.331080280967463e-09 8.134832024609278 0.745790978652328 AVGAQASVGSRS(ph)EGEGEAASADDGSLNTSGAGPK ddPTM_A459_Selumetinib_30min_R1 1 AVGAQASVGSRSEGEGEAASADDGSLNTSGAGPK 34 1 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R2I2 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 AVGAQAS(0.002)VGS(0.049)RS(0.89)EGEGEAAS(0.049)ADDGS(0.008)LNTSGAGPK 113.79 3.3009e-15 5250300.0 413.75 275.27 749.56 786.92 431.83 364.17 284.26 406.61 307.77 290.67 True False 423.38956998264615 243.04126043044883 647.7738690383601 649.4991943178712 392.77105274577866 360.5067804399044 262.8180393409609 395.82538194457925 522.2632113685747 327.9803258655638 1.2908992905757088 0.7410239007143046 1.9750387994427347 1.9802992530231678 1.1975445530436237 1.0991719685883623 0.8013225752104645 1.2068570908939962 1.5923614015270102 1.0 8.357465466119674 -6.496060298592545 24.662320420426123 1.1335574163377269 1.4909806660972063 0.17034519167535023 0.37702606461588256 1242.5413986424821 1142645.5540633218 0.12720593897954188 0.14379733518380378 3.1910947643189263e-07 6.496060298592545 0.35742324975947937 AVGMPS(ph)PVSPK ddPTM_A459_Selumetinib_30min_R1 1 AVGMPSPVSPK 11 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 AVGMPS(0.991)PVS(0.009)PK 85.845 0.0343 10261000.0 6102.1 7043.9 7863.3 7854.2 7315.7 5636.6 6419.6 6389.2 3628.5 5487.6 True False 6244.267057380317 6219.196913379733 6795.507050015125 6482.61141159384 6653.996226691739 5579.900921623318 5935.3644035503885 6219.73766095351 6157.299484845416 6191.986913750531 1.0084431934947549 1.004394389072234 1.0974679282548803 1.0469355801120832 1.0746140648190365 0.9011486941666568 0.958555708567429 1.0044817192913236 0.9943980132083153 1.0 12.596186707131626 -6.739513784752835 24.999997827401305 0.9711743296579379 1.0469090818059226 0.4960265009931393 0.03762096084232811 214.78376290465158 244900.07190104562 0.013117513717859745 0.013107048678169116 1.8217392491386132e-07 6.739513784752835 0.07573475214798464 AVGMPS(ph)PVSPK ddPTM_A459_Selumetinib_30min_R2 4 AVGMPSPVSPK 11 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 AVGMPS(0.999)PVS(0.001)PK;AVGMPS(0.999)PVS(0.001)PK;AVGMPS(0.999)PVS(0.001)PK;AVGMPS(0.803)PVS(0.197)PK 115.33 0.0062096 25707900.0 305527.0 271993.0 305981.0 311445.0 343202.0 264026.0 263337.0 276765.0 223927.0 285849.0 True False 288547.03246148635 292853.98850466113 286294.5155869229 269025.6537274079 300085.89649519173 300393.18491060333 275582.69229236594 277570.34032908746 268718.6570431445 277595.7966451043 1.0394502940921069 1.054965500356851 1.0313359173551881 0.9691272597738467 1.0810174365818663 1.0821244000846477 0.9927480733603757 0.9999082971848836 0.9680213471916909 1.0 18.08262619723348 -7.387340339046511 9.002555814856166 0.9896646955258018 1.0413560463691742 0.415204391303021 0.030696758934424778 0.3717781206265564 25.429448212033456 0.013725759088441867 0.00923491220697376 4.098827685220307e-08 7.387340339046511 0.0516913508433724 AVGMPSPVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AVGMPSPVSPK 11 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 AVGMPS(0.171)PVS(0.829)PK;AVGMPS(0.042)PVS(0.958)PK 131.06 0.0022751 122782000.0 9767.599999999999 11938.6 13187.6 12922.0 8894.9 10861.5 9855.900000000001 10363.8 7212.1 10523.900000000001 True False 9995.1660755589 10540.823161895438 11396.796354301568 10665.415275981708 8090.35786552214 10752.24317145295 9112.461527969388 10088.91835763319 12238.406949057091 11874.745076466805 0.8417162651657402 0.8876673220366714 0.9597508225155563 0.8981595147771443 0.6813079197426724 0.9054714945217298 0.7673816548726027 0.8496113636685356 1.03062481512222 1.0 13.535608921972843 -8.257996669680145 24.094489627175584 1.015312430479528 0.8490979195316412 0.44770149322360275 0.07394011757957761 159.59669632282274 1117004.4788951154 0.056802559526160666 0.01946896590560023 5.520816728171799e-09 8.257996669680145 -0.16621451094788686 AVGMPSPVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 AVGMPSPVSPK 11 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 AVGMPS(0.119)PVS(0.881)PK;AVGMPS(0.117)PVS(0.883)PK;AVGMPS(0.001)PVS(0.999)PK 147.96 0.00065727 55040000.0 542294.0 467999.0 496021.0 492706.0 462958.0 374202.0 451418.0 433033.0 309198.0 394489.0 True False 512155.47045488295 503893.0184460364 464107.5488868297 425598.5928347422 404797.0771429678 425744.9288324549 472409.83146779786 434293.0543375273 371046.23971395276 383099.0775644863 1.336874715832937 1.3153073133182291 1.2114556679106265 1.1109360939745465 1.0566380888109268 1.1113180734839805 1.233127039801546 1.133631166899439 0.9685385881710855 1.0 18.547358026445686 -1.5228787452807493 0.3176503508523853 1.054501356701186 4.0679704306802265 0.6633274919988659 0.06873305538739523 38.85325660824905 0.5546702747208243 0.0717475324030125 67.8449281161787 0.02999999999997156 1.5228787452807493 3.0134690739790404 AVGNGAAEISLKS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 AVGNGAAEISLKSPR 15 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 AVGNGAAEIS(0.066)LKS(0.934)PR 123.63 0.006741500000000001 5507500.0 1794.9 2443.6 2071.3 2084.5 1943.4 1891.2 1888.0 2064.3 1039.2 1890.5 True False 1836.7176777325722 2157.502176001179 1790.028836836485 1720.4812059111498 1767.6198131351373 1872.1762450722103 1745.5866399624788 2009.548058208591 1763.4464998350172 2133.1640900294096 0.8610297193345542 1.011409382937547 0.839142588797192 0.8065395503106514 0.8286375255411165 0.8776522414862136 0.8183086561983203 0.9420503877790695 0.8266811297253297 1.0 11.058779231478104 -10.07312088887637 7.152345939262884 0.9999999889670564 0.8693557059194179 0.30021000094016237 0.060452883540621755 0.0 0.0 0.05979068469787675 0.014501370976506217 8.450435886846442e-11 10.07312088887637 -0.13064428304763853 AVGNGAAEISLKS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 AVGNGAAEISLKSPR 15 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 AVGNGAAEIS(0.004)LKS(0.996)PR;AVGNGAAEIS(0.001)LKS(0.999)PR;AVGNGAAEIS(0.255)LKS(0.745)PR 89.669 0.008995900000000001 19214600.0 123716.0 124842.0 133633.0 136219.0 132191.0 96489.0 101781.0 104277.0 86306.0 119643.0 True False 116840.35999438733 134416.9799697007 125035.19826860935 117665.73720911828 115583.98477746597 109779.48391006657 106514.01817522546 104580.42880601324 103569.61159112424 116188.59572015378 1.005609537409363 1.156886174039412 1.076140024704 1.012713308735758 0.9947962970122812 0.9448387187196592 0.9167338456501356 0.9000920284629361 0.891392231304499 1.0 16.82610894502603 -6.308876613766476 1.2039460208416293 0.9193727825214653 1.0884874097253558 0.6628778309840111 0.045484626516139305 0.25239525561345594 0.7535612045409673 0.018471066644646802 0.025709431181348788 4.910473664789963e-07 6.308876613766476 0.1691146272038906 AVGS(ph)PATATPDLVSMATTQGVR ddPTM_A459_Selumetinib_30min_R2 1 AVGSPATATPDLVSMATTQGVR 22 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4 Q96L91-3 EP400 E1A-binding protein p400 1 AVGS(0.973)PAT(0.027)ATPDLVSMATTQGVR 86.179 0.0034496 0.0 7516.2 5703.7 6087.5 7749.1 8701.3 7158.7 7450.3 9906.4 6979.7 7403.5 True False 7098.479693732539 6141.155449713895 5695.836877568857 6693.659212056891 7608.164903391027 8144.745944791565 7796.753712489378 9935.225983907192 8375.835029112326 7189.7417183968855 0.9873066337792319 0.8541552242412407 0.792217175617662 0.9310013452818988 1.0581972484384932 1.132828725119714 1.0844275104541363 1.3818613203427388 1.1649702252419585 1.0 12.811724229418337 -6.477816648787589 1.5563474549827907 1.1831564171061426 0.8724035444197601 0.591456827249222 0.10218463519440346 0.25012650306154205 1.2283856355877285 0.040495208861713185 0.04623983635142439 3.328000257428831e-07 6.477816648787589 -0.3107528726863825 AVGS(ph)PLCVPAR ddPTM_A459_Selumetinib_30min_R1 2 AVGSPLCVPAR 11 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 AVGS(1)PLCVPAR;AVGS(1)PLCVPAR 116.03 0.0060073 37625000.0 4435.299999999999 4614.299999999999 5072.299999999999 5568.5 4825.5 4270.1 4489.799999999999 4351.3 2964.3 4092.0 True False 4538.633860408535 4074.055610870126 4383.509520149521 4596.06600869093 4389.034377011222 4227.146670940594 4151.13077124128 4235.8893889856345 5030.200596094054 4617.248059455353 0.982973797804554 0.8823558012065522 0.9493770886259459 0.9954124078906601 0.9505736578356914 0.9155121441405133 0.8990486796004944 0.9174056352270787 1.0894369397791057 1.0 12.172817527236198 -8.252838788152378 24.99394637946211 1.0447184719588918 0.9356752449911728 0.5526437817158917 0.03890972802949543 411.9587512206058 1197190.2654136706 0.027506221863657 0.010040629879124059 5.586775395866434e-09 8.252838788152378 -0.10904322696771895 AVGS(ph)PLCVPAR ddPTM_A459_Selumetinib_30min_R2 2 AVGSPLCVPAR 11 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 AVGS(1)PLCVPAR;AVGS(1)PLCVPAR 107.85 0.010311 13294100.0 59136.0 55879.0 63335.0 77262.0 79318.0 56858.0 49891.0 59487.0 57582.0 64803.0 True False 55849.4578601644 60164.73962069585 59260.095053934056 66738.78231561603 69353.36372808309 64689.673394465266 52211.03035714104 59660.09732139697 69100.00897550693 62931.96901158552 0.8874576584419716 0.9560282407439018 0.9416532802751574 1.0604909295517146 1.1020370857189519 1.0279302302229913 0.829642408733933 0.9480093863011626 1.0980112343662074 1.0 15.94150546211951 -5.125243192329223 1.751828679731785 1.0022145265072768 0.8923558179318067 0.18242388485309724 0.07670947728339059 1.0235546058680527 4.934211623048687 0.024047753506508923 0.14961603961253986 7.4947440784747065e-06 5.125243192329223 -0.10985870857547009 AVIVSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 AVIVSSPK 8 0 Q14966-3;Q14966;Q14966-5 Q14966-3 ZNF638 Zinc finger protein 638 1 AVIVS(0.238)S(0.762)PK;AVIVS(0.2)S(0.8)PK 121.73 0.0067496000000000006 25147000.0 14906.3 25590.0 27137.0 28497.0 17576.3 21510.6 20219.2 17760.4 11264.2 18364.7 True False 15253.5877873893 22593.910903531752 23451.944452870997 23520.533904941254 15986.526768347801 21294.222894062124 18694.04946542869 17289.33649809032 19114.524695382603 20721.98813232641 0.7361063856413287 1.0903350952259805 1.1317420077220217 1.135051991862166 0.7714764947388777 1.0276148580957358 0.9021359025037696 0.8343473795894548 0.9224271615889909 1.0 14.338874805887054 -6.251409681442301 24.99823842971094 0.9069051735150775 1.0358416739301635 0.16019150487586287 0.1260781779023048 1208.2568326209275 3011485.325625335 0.037503482538367626 0.047844613932725065 5.605189742250664e-07 6.251409681442301 0.12893650041508598 AVIVSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 AVIVSSPK 8 0 Q14966-3;Q14966;Q14966-5 Q14966-3 ZNF638 Zinc finger protein 638 1 AVIVS(0.324)S(0.676)PK;AVIVS(0.176)S(0.824)PK;AVIVS(0.341)S(0.659)PK;AVIVS(0.306)S(0.694)PK 123.86 0.0057027 272419000.0 848090.0 840710.0 799590.0 748650.0 705500.0 563280.0 690260.0 674190.0 461999.0 667810.0 True False 800956.552973262 905189.7536912843 748145.2499277678 646682.578506716 616868.7827499768 640866.707053262 722358.4577242413 676151.7812818368 554411.7093306106 648528.5901212442 1.235036612377445 1.3957592116672244 1.1536041144892317 0.9971535385754032 0.9511820945853005 0.9881857435667566 1.1138421169515356 1.0425936367052506 0.8548762811319726 1.0 19.30681065094455 -5.545585215153312 3.26329224634822 0.997777651983828 1.3137274049529084 0.7624307542485671 0.07232939551603593 0.11156283372056743 2.4546917880246086 0.020436524104363047 0.04178942340296093 2.847179085713633e-06 5.545585215153312 0.31594975296908046 AVLASQTSLT(ph)PLGR ddPTM_A459_Selumetinib_30min_R2 1 AVLASQTSLTPLGR 14 0 E7EPP7;Q6ZWJ1 E7EPP7 STXBP4 Syntaxin-binding protein 4 1 AVLASQTS(0.005)LT(0.995)PLGR 148.85 0.00037015 0.0 16869.0 16615.0 18380.0 21661.0 20728.0 16374.0 15553.0 16935.0 15114.0 17395.0 True False 15931.488511957401 17889.31707435461 17197.4508106309 18710.734432690788 18123.96332932886 18629.36987162713 16276.245317684832 16984.27804625982 18137.2223204441 16892.761152362236 0.9430955880015853 1.0589930747853509 1.0180366995969783 1.1076184801248037 1.0728834182796965 1.1028019459697416 0.9635041406720422 1.0054175213318983 1.0736683101630098 1.0 14.044117538076385 -10.446622390536213 14.846318964685555 0.9999949249434188 1.0402139651108018 0.04441230580029609 0.052932754788038265 0.0 0.0 0.052097574483065005 0.012635517790127088 3.5758361408376295e-11 10.446622390536213 0.04021904016738298 AVLSDS(ph)PQLSEGK ddPTM_A459_Selumetinib_30min_R1 4 AVLSDSPQLSEGK 13 0 Q7Z4H7;Q5VY60;Q7Z4H7-3;Q5SYF9;Q7Z4H7-2 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 AVLSDS(0.995)PQLS(0.005)EGK;AVLS(0.069)DS(0.922)PQLS(0.009)EGK;AVLS(0.007)DS(0.993)PQLSEGK;AVLS(0.009)DS(0.991)PQLSEGK 216.0 2.1476000000000003e-08 123009800.0 15533.7 17433.5 19527.2 19855.5 17006.5 14721.4 16669.6 15564.5 8623.599999999999 13410.900000000001 True False 15895.604986681416 15392.37771538573 16875.513495231688 16388.109658896057 15468.265077741438 14573.316081961742 15412.198651228036 15151.67889937878 14633.619357175952 15132.319648228187 1.0504407358684495 1.0171856049305694 1.1151967370189413 1.0829872775529763 1.0222005242634817 0.9630589639089538 1.0184954461382012 1.0012793313649608 0.967044028764577 1.0 13.885345536204213 -6.476287723408004 4.680798068413831 0.991682528264585 1.0657325871530823 0.6276954966587752 0.02771061630349739 0.14938010951739644 7.278136671315769 0.009375400735580573 0.010349132687493589 3.339737065877717e-07 6.476287723408004 0.07405005888849725 AVLSDS(ph)PQLSEGK ddPTM_A459_Selumetinib_30min_R2 3 AVLSDSPQLSEGK 13 0 Q7Z4H7;Q5VY60;Q7Z4H7-3;Q5SYF9;Q7Z4H7-2 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 AVLS(0.13)DS(0.837)PQLS(0.032)EGK;AVLS(0.098)DS(0.89)PQLS(0.012)EGK;AVLS(0.002)DS(0.979)PQLS(0.019)EGK 146.27 0.0006047 91748000.0 381775.0 367818.0 411545.0 473010.0 442730.0 336459.0 358138.0 360699.0 304302.0 353420.0 True False 360557.473866414 396028.4578787227 385066.64275631704 408585.22201223654 387110.2993435821 382803.1731792956 374792.1266369838 361748.574373066 365170.902908282 343215.84630456247 1.0505268848993148 1.1538757960706028 1.1219372499911238 1.1904614149128379 1.1278916853974996 1.1153423634164146 1.0920012309233567 1.0539972972345164 1.0639686565760635 1.0 18.388756638163677 -7.958432267939705 0.8538546005124857 1.0094026438211734 1.133422952710505 0.582998648546002 0.03442344325139162 0.40281653753552765 0.5630012171791791 0.03184183500526311 0.012865464099078718 1.100443455789736e-08 7.958432267939705 0.12402030888933169 AVLVDLEPGTMDS(ph)VR ddPTM_A459_Selumetinib_30min_R1 2 AVLVDLEPGTMDSVR 15 0 P04350;M0QY85;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;A0A075B724;P68371;Q3ZCM7 P04350;P68371;Q3ZCM7 TUBB4A;TUBB8;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta-8 chain 1 AVLVDLEPGTMDS(1)VR;AVLVDLEPGT(0.034)MDS(0.966)VR 164.66 9.2752e-05 4687600.0 1156.02 2006.46 1814.6999999999998 1966.8000000000002 2005.27 1573.52 1810.81 1663.73 821.0799999999999 1484.29 True False 1182.9530167766502 1771.5427304220518 1568.2737074335766 1623.3353014085153 1823.8936825591738 1557.6918174418495 1674.2191438085054 1619.602475843327 1393.3127906895074 1674.8130797089393 0.7063194281849244 1.0577554903798116 0.9363873058037749 0.9692635680219489 1.0890132783511237 0.9300690544598302 0.9996453718282776 0.9670347667244114 0.8319213693576163 1.0 10.709784374844544 -4.750577177003016 24.992830164365795 0.976083872025506 0.7063188525839932 0.5911786812975817 0.06719737053206339 328.9842660017633 756910.2130857295 0.01634707087726265 0.23720913093771406 1.7759176479286653e-05 4.750577177003016 -0.26976501944151277 AVLVDLEPGTMDSVR ddPTM_A459_Selumetinib_30min_R1 1 AVLVDLEPGTMDSVR 15 0 P04350;M0QY85;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;A0A075B724;P68371;Q3ZCM7 P04350;P68371;Q3ZCM7 TUBB4A;TUBB8;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta-8 chain 0 132.03 0.0091345 3817300.0 2383.1 2328.0 2584.4 2856.7 3047.8 2448.6 2554.9 2606.3 1833.6 2192.0 False True 2438.621593294609 2055.4366777421606 2233.4526750930386 2357.8309719003996 2772.127028132795 2423.969307150918 2362.1818360382094 2537.172457544469 3111.485279154625 2473.3645518881067 0.9859531590007725 0.8310285987454175 0.9030018132135332 0.9532888995681968 1.1207919293646464 0.9800291288643717 0.955047986854577 1.0257980189809275 1.2579970375897045 1.0 11.272259180451396 -6.04376802860556 4.826883613278859 1.0489406546767486 0.902269726458235 0.37727993224362644 0.08807181813423777 0.22758718270377037 12.242590213068375 0.026629812925812957 0.03612214174011367 9.04132272445295e-07 6.04376802860556 -0.14667092821851357 AVLVDLEPGTMDSVR ddPTM_A459_Selumetinib_30min_R2 4 AVLVDLEPGTMDSVR 15 0 P04350;M0QY85;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;A0A075B724;P68371;Q3ZCM7 P04350;P68371;Q3ZCM7 TUBB4A;TUBB8;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta-8 chain 0 ;;; 160.86 0.0017368 15258300.0 93122.0 83416.0 101765.0 107381.0 122868.0 87336.0 82083.0 86090.0 79218.0 91542.0 False True 87946.65203690183 89813.73897528532 95217.5506933546 92755.52255744298 107432.22338614328 99365.74124272782 85900.02214437879 86340.50764703323 95063.81353585667 88898.94460532 0.9892879204286844 1.0102902725564031 1.0710762778578193 1.0433815943400098 1.2084758020818416 1.117738142830342 0.9662659385411676 0.9712208399138446 1.0693469304715204 1.0 16.439878671251186 -10.783806010533914 5.530244836335158 0.9999958386698453 1.0508735301525391 0.04307020077443624 0.07004118997058081 3.950641204517579e-06 5.279594755439529e-07 0.07455279843146552 0.018080230666147376 1.6451063907262713e-11 10.783806010533914 0.05087769148269383 AVNTQALS(ph)GAGILR ddPTM_A459_Selumetinib_30min_R1 1 AVNTQALSGAGILR 14 0 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 AVNTQALS(1)GAGILR 110.22 0.004320399999999999 2849000.0 2058.7 2790.8 2703.8 2353.3 2137.9 2065.2 1987.1 2146.3 1392.9 2386.0 True False 2106.663704467126 2464.0518385922796 2336.6388109102913 1942.340331912071 1944.5273224769026 2044.4259630515694 1837.2114471766129 2089.3731518350514 2363.6495666091178 2692.266341608129 0.7824871083181115 0.9152333112482721 0.8679077455295837 0.7214517753662825 0.7222640986238414 0.7593698778815489 0.6824033041542318 0.7760648044156876 0.8779404660228661 1.0 11.394605425186096 -8.538571359553542 2.8112970970230653 0.9991322146338706 0.7786136628390377 0.5308576832921834 0.06549394845807936 0.2333467986014786 4.5761193899717645 0.07155654160013293 0.019195307961012324 2.89353433719685e-09 8.538571359553542 -0.22051855179483293 AVNTQALS(ph)GAGILR ddPTM_A459_Selumetinib_30min_R2 1 AVNTQALSGAGILR 14 0 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 AVNTQALS(1)GAGILR 117.48 0.002498 4684300.0 12313.0 16942.0 19040.0 22893.0 17012.0 16504.0 12709.0 13252.0 13198.0 14889.0 True False 11628.692752844354 18241.39692288388 17814.98712918457 19774.93390737226 14874.800470790373 18777.276191604615 13299.993682405739 13290.5611260133 15837.968782931128 14459.115883732184 0.804246459213159 1.261584530448857 1.232093806594914 1.367644748571443 1.0287489629657005 1.298646220321863 0.9198345036690271 0.919182143146552 1.0953621860621698 1.0 13.819691719587409 -7.2734284429571145 24.872067430582764 0.9768598809600942 1.1758621036490742 0.24416319956306576 0.15596929917538338 977.8759719522186 2028656.8132366522 0.0639034440985474 0.04345812958051026 5.32809005995757e-08 7.2734284429571145 0.19900222268897994 AVPAPSPGPTHNS(ph)PELGRPPAAGVLAPDMSDKDK ddPTM_A459_Selumetinib_30min_R2 1 AVPAPSPGPTHNSPELGRPPAAGVLAPDMSDKDK 34 2 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 AVPAPS(0.058)PGPT(0.243)HNS(0.699)PELGRPPAAGVLAPDMSDKDK 45.137 0.0081129 6080900.0 20193.0 15061.0 19299.0 16375.0 20431.0 15858.0 16369.0 13027.0 13139.0 18884.0 True False 19070.7538989837 16216.130271252177 18057.323351162446 14144.69675154941 17864.27512454255 18042.29555540876 17130.190934558163 13064.906413264063 15767.16713433339 18338.769853475627 1.0399145663180536 0.8842539821818441 0.9846529235841933 0.7713001943185769 0.9741261418991444 0.983833468633084 0.9340970562053043 0.7124199996865088 0.8597723435274554 1.0 14.162609247173126 -7.598355510078557 24.999999999967745 0.8363081915499797 0.9352781742331129 0.12279228911106133 0.09457247688812004 63.470674558328575 21020.597514769837 0.04278670182711163 0.02470291511669958 2.5214159160379654e-08 7.598355510078557 0.09896998268313317 AVPETEDVQASVSDTAQQPS(ph)EEQSKSLEKPK ddPTM_A459_Selumetinib_30min_R2 1 AVPETEDVQASVSDTAQQPSEEQSKSLEKPK 31 2 H0YME2;H0YK21;H0YK54;Q6FIF0-2;Q6FIF0 H0YME2 ZFAND6 AN1-type zinc finger protein 6 1 AVPETEDVQASVSDTAQQPS(0.42)EEQS(0.29)KS(0.29)LEKPK 80.98100000000002 4.9124e-06 5738400.0 19920.0 19984.0 17526.0 13916.0 12459.0 13391.0 14753.0 12705.0 8166.6 17322.0 True False 18812.926146078098 21516.708541312222 16398.396240866008 12020.616793561017 10893.7890351268 15235.48869860504 15439.043732514901 12741.96944657403 9800.148193869176 16821.86885203902 1.1183612422348506 1.2790914452233486 0.9748260663010886 0.7145827196307007 0.6475968354613784 0.9056953678935803 0.9177959873729188 0.757464557514342 0.582583794943882 1.0 14.038050372526271 -5.505160136232843 3.873548893492169 0.7848373222572378 1.1933290144669044 0.6274957334867897 0.12589048553653692 0.13558599194463802 4.484154144887315 0.03501156217475745 0.07208593389780565 3.1249269087957092e-06 5.505160136232843 0.40849169220966663 AVPETEDVQASVSDTAQQPSEEQSKS(ph)LEKPK ddPTM_A459_Selumetinib_30min_R1 1 AVPETEDVQASVSDTAQQPSEEQSKSLEKPK 31 2 H0YME2;H0YK21;H0YK54;Q6FIF0-2;Q6FIF0 H0YME2 ZFAND6 AN1-type zinc finger protein 6 1 AVPETEDVQAS(0.017)VS(0.012)DT(0.091)AQQPS(0.091)EEQS(0.177)KS(0.612)LEKPK 56.452 0.0012376 6775900.0 627.84 726.84 701.87 623.82 620.27 780.18 604.2 534.27 359.99 580.4 True False 642.4674504360233 641.7412349012516 606.5599090959411 514.8815475516877 564.166688017563 772.3320975467627 558.6247075557892 520.0994240464581 610.8767373706771 654.8999935747523 0.9810161196202395 0.9799072243050819 0.9261870744341463 0.7861987366059083 0.8614547160675262 1.1793130327136068 0.8529923851526593 0.7941661767432776 0.9327786583661796 1.0 9.355130806670251 AVPIAVADEGES(ph)ESEDDDLKPR ddPTM_A459_Selumetinib_30min_R2 1 AVPIAVADEGESESEDDDLKPR 22 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 AVPIAVADEGES(0.949)ES(0.051)EDDDLKPR 112.61 2.237e-05 5452800.0 18526.0 14418.0 16116.0 17292.0 16940.0 14673.0 14519.0 15031.0 11782.0 13436.0 True False 17496.399085453962 15523.814238823043 15079.114105774084 14936.799769636185 14811.845754478525 16694.072561767727 15194.162268852711 15074.737721484003 14138.729216585443 13048.067769079558 1.340918777791434 1.1897404668306784 1.1556587820234627 1.144751853989632 1.135175415748426 1.2794287136773024 1.1644760387326332 1.1553233772441858 1.0835879661884085 1.0 13.67154855980363 -14.52287874526654 0.07405935511337346 0.36524497379117066 1.3919226605808765 0.5682425714265615 0.05876644619248447 240.64265171392668 1.2700094545143101 25.363589902601323 2.794199792709686 3.0000000000953073e-15 14.52287874526654 1.0266776867897058 AVPIGT(ph)PPK ddPTM_A459_Selumetinib_30min_R1 1 AVPIGTPPK 9 0 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 AVPIGT(1)PPK 119.34 0.016205 95066000.0 11297.0 16099.0 10163.0 10463.0 10603.0 10613.0 11716.0 10532.0 6203.2 10675.0 True False 11560.198119864552 14214.121595777944 8782.920421363006 8635.833464834905 9643.960522111693 10506.242855833001 10832.252687394282 10252.657147242586 10526.377336197627 12045.240233305447 0.9597316363936238 1.1800612790167087 0.7291610836517789 0.7169498737730916 0.8006449298907178 0.8722319067396371 0.8992973554352849 0.8511791337206944 0.873903478246277 1.0 13.556175546886085 -5.262128979016086 24.999988513136795 0.8346573740233868 1.0698964596426221 0.49020195846613934 0.09227976831658737 46.05966577689977 1669873.028382141 0.024071264041415352 0.05543109005237554 5.468535313919136e-06 5.262128979016086 0.23523908561923534 AVPMAPAPAS(ph)PGSSNDSSAR ddPTM_A459_Selumetinib_30min_R1 12 AVPMAPAPASPGSSNDSSAR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 AVPMAPAPAS(0.998)PGS(0.002)S(0.001)NDSSAR;AVPMAPAPAS(0.959)PGS(0.029)S(0.009)NDS(0.001)S(0.002)AR;AVPMAPAPAS(0.978)PGS(0.02)S(0.001)NDSSAR;AVPMAPAPAS(0.542)PGS(0.442)S(0.014)NDS(0.001)SAR;AVPMAPAPAS(0.963)PGS(0.029)S(0.008)NDSSAR;AVPMAPAPAS(0.962)PGS(0.025)S(0.007)NDS(0.002)S(0.005)AR;AVPMAPAPAS(0.889)PGS(0.045)S(0.064)NDS(0.001)S(0.001)AR;AVPMAPAPAS(0.957)PGS(0.032)S(0.009)NDS(0.001)SAR;AVPMAPAPAS(0.877)PGS(0.082)S(0.025)NDS(0.008)S(0.008)AR;AVPMAPAPAS(0.906)PGS(0.068)S(0.022)NDS(0.002)S(0.002)AR;AVPMAPAPAS(0.86)PGS(0.132)S(0.007)NDSSAR;AVPMAPAPAS(0.786)PGS(0.162)S(0.05)NDSS(0.002)AR 266.99 8.665299999999997e-59 310367900.0 26462.829999999994 28779.46 30556.86 32804.03 28394.569999999996 26553.89 28702.760000000006 25791.929999999997 15463.480000000003 22910.690000000006 True False 27079.36245129636 25409.947443992016 26407.406248817308 27075.421968407547 25826.286156968497 26286.781975603055 26537.687704475356 25107.844232404143 26240.396152106237 25851.50023051884 1.04749674911818 0.9829196455683624 1.0215038204104765 1.0473443214890799 0.9990246572413397 1.0168377750305704 1.026543429504584 0.9712335457716772 1.015043456593219 1.0 14.65796038590499 -7.733580303342555 24.999945442673607 0.9948538325287702 1.018947749867735 0.22630478910667018 0.020921444807744168 308.0842691626495 276466.50586017664 0.009508231606724989 0.005488033255544049 1.846799280399563e-08 7.733580303342555 0.02409391733896482 AVPMAPAPAS(ph)PGSSNDSSAR ddPTM_A459_Selumetinib_30min_R2 10 AVPMAPAPASPGSSNDSSAR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 AVPMAPAPAS(0.745)PGS(0.201)S(0.054)NDSSAR;AVPMAPAPAS(0.575)PGS(0.406)S(0.016)NDS(0.002)SAR;AVPMAPAPAS(0.998)PGS(0.001)SNDSSAR;AVPMAPAPAS(0.928)PGS(0.05)S(0.014)NDS(0.004)S(0.005)AR;AVPMAPAPAS(0.955)PGS(0.03)S(0.015)NDSSAR;AVPMAPAPAS(0.999)PGS(0.001)SNDSSAR;AVPMAPAPAS(0.993)PGS(0.005)S(0.002)NDSSAR;AVPMAPAPAS(0.847)PGS(0.115)S(0.036)NDS(0.002)SAR;AVPMAPAPAS(0.508)PGS(0.358)S(0.113)NDS(0.011)S(0.011)AR;AVPMAPAPAS(0.704)PGS(0.219)S(0.068)NDS(0.007)S(0.002)AR 257.88 1.8724999999999998e-47 433484300.0 1143877.0 1085423.3 1172203.9 1229014.0 1289671.0 943810.1 941800.1 1020864.3 864505.2 1168260.9 True False 1080304.895642438 1168671.7769240015 1096785.577273104 1061620.173032596 1127650.999174975 1073811.3742199454 985595.6707914948 1023834.8460998185 1037430.3962935001 1134530.1723106478 0.9522046411883682 1.030093165829005 0.9667310786801986 0.9357355132040612 0.9939365445683457 0.946481107710834 0.8687258345753602 0.9024306898904407 0.9144141086883667 1.0 20.1136635466589 -7.006821544988483 9.525175199128515 0.9124302404855296 0.9754922228705347 0.2918318326206023 0.038991969911665994 0.16612443410043878 177.51563784749183 0.013845438994034075 0.011532198641905944 9.844155267324636e-08 7.006821544988483 0.06306198238500516 AVPMAPAPASPGS(ph)SNDSSAR ddPTM_A459_Selumetinib_30min_R2 1 AVPMAPAPASPGSSNDSSAR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 AVPMAPAPAS(0.079)PGS(0.608)S(0.184)NDS(0.099)S(0.03)AR 115.56 0.0010259 6261200.0 10102.0 10244.0 8148.7 11243.0 12758.0 9506.4 11098.0 11060.0 7909.6 10682.0 True False 9540.571281510085 11029.681860348397 7624.421513633731 9711.684004743203 11155.225982032887 10815.820309492858 11614.078990269803 11092.182768918436 9491.741012689208 10373.582904830895 0.9196987549082117 1.0632470923052018 0.7349843909844397 0.9361938005258096 1.075349383561391 1.042631114892427 1.1195822211881314 1.069272099204306 0.9149915800324862 1.0 13.340626648461267 -6.171579746747586 5.567766713523569 1.0445823659277509 0.9091398126877617 0.3126338479932078 0.08969127829381866 0.27512200459519853 13.398944886272576 0.026966959073737484 0.035038502348037445 6.736281900313518e-07 6.171579746747586 -0.13544255323998922 AVPMAPAPASPGSS(ph)NDSSAR ddPTM_A459_Selumetinib_30min_R1 1 AVPMAPAPASPGSSNDSSAR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 AVPMAPAPAS(0.195)PGS(0.27)S(0.525)NDS(0.005)S(0.005)AR 126.43 0.0062671 0.0 560.6 810.76 692.54 660.4 721.37 712.66 628.22 686.64 421.99 524.24 True False 573.6608892622876 715.8358422879019 598.4968718499201 545.0735372433312 656.1222108682174 705.4912874435072 580.8328596171767 668.4280766789456 716.0862090698408 591.5313105300277 0.969789559826127 1.2101402403306327 1.0117754735816962 0.9214618525516949 1.1091926989973102 1.1926524849739033 0.9819139735760313 1.1299961046525437 1.2105634922827817 1.0 9.208310724106285 AVPPGNDPVS(ph)PAMVR ddPTM_A459_Selumetinib_30min_R2 3 AVPPGNDPVSPAMVR 15 0 O94966-2;O94966-7;O94966-6;O94966-5;A0A0A0MR08;E7ESU0;O94966-4;O94966-3;O94966;H0YB23 O94966-2 USP19 Ubiquitin carboxyl-terminal hydrolase 19;Ubiquitin carboxyl-terminal hydrolase 1 AVPPGNDPVS(1)PAMVR;AVPPGNDPVS(1)PAMVR;AVPPGNDPVS(1)PAMVR 101.42 0.006954000000000001 16675700.0 77639.0 59762.0 68824.0 95704.0 96047.0 60911.0 74743.0 75068.0 57973.0 72039.0 True False 73324.13519354211 64345.55323488292 64395.93876990545 82668.95010139127 83980.71718892566 69300.93735499453 78218.69760044487 75286.43545182356 69569.21990095981 69959.04689019984 1.0481008311708957 0.9197602897002406 0.9204805044153097 1.1816763346010062 1.2004268342982534 0.9905929316584572 1.1180640828799238 1.0761501020730746 0.9944277830163716 1.0 16.09422301391838 -5.7446073371416135 24.999924104484926 1.0862186863059708 0.958478492402184 0.32585596387285254 0.07697391367789806 273.3729810182302 406026.08615529205 0.021316198325056677 0.0367957518562084 1.8004980811199154e-06 5.7446073371416135 -0.12774019390378688 AVPPVS(ph)PELR ddPTM_A459_Selumetinib_30min_R1 2 AVPPVSPELR 10 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 AVPPVS(1)PELR;AVPPVS(1)PELR 158.08 0.00048138 333420000.0 12573.800000000001 14233.4 14789.5 15093.6 14230.3 11652.900000000001 12742.8 11727.0 6802.4 10302.2 True False 12866.74507564423 12566.94691107186 12781.167132908417 12457.786101962358 12943.171877563514 11535.682405986654 11781.60033671286 11415.961865335534 11543.175972361167 11624.587721925927 1.1068560351069816 1.0810660310445663 1.0994942305610533 1.071675520884485 1.1134306168252759 0.9923519596508715 1.013506940507729 0.9820530532711375 0.9929965903727317 1.0 13.504891929999774 -6.767569298578651 24.999988444329624 0.9961428335224316 1.0927668412138103 0.9309426554738458 0.013385414189294816 33.956931808602135 138487.6811170626 0.004431521840695572 0.00400725105121924 1.7077751956755125e-07 6.767569298578651 0.09662400769137869 AVPPVS(ph)PELR ddPTM_A459_Selumetinib_30min_R2 5 AVPPVSPELR 10 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 AVPPVS(1)PELR;AVPPVS(1)PELR;AVPPVS(1)PELR;AVPPVS(1)PELR;AVPPVS(1)PELR 131.12 0.0026642 292915100.0 314516.0 308414.0 366422.0 388293.0 419649.0 287076.0 280702.0 296607.0 255595.0 340255.0 True False 297036.4598273044 332068.36209268734 342846.8074501082 335406.8235572131 366928.9409103404 326618.1131835366 293755.199200461 297470.07726406807 306721.1419209947 330430.9540613406 0.8989365438570961 1.0049553711939554 1.0375747285058008 1.015058726898052 1.110455713668473 0.9884610057534253 0.8890062979569668 0.9002488223571399 0.9282457897817149 1.0 18.333989316094375 -7.082384363093129 5.872036524515715 0.9222211768265094 1.0175962528894538 0.3330245222043662 0.055674782833192424 0.24760660135598653 13.860224608028691 0.02188142562193998 0.01698705087431083 8.272097352697967e-08 7.082384363093129 0.09537507606294438 AVPS(ph)PPPPPIVK ddPTM_A459_Selumetinib_30min_R1 1 AVPSPPPPPIVK 12 0 A0A286YF23;A0A0J9YY01;A0A2R8YFM0;Q96JP2 A0A286YF23 MYO15B Unconventional myosin-XVB 1 AVPS(1)PPPPPIVK 97.911 0.015767 322640000.0 4952.2 5381.9 6129.5 6593.1 5339.3 4827.4 5217.6 5177.6 2607.4 3844.0 True False 5067.57662469622 4751.78464602257 5297.147566933439 5441.738852814967 4856.361257729977 4778.840738928505 4824.03223128614 5040.273228784965 4424.567363038704 4337.414843730782 1.1683403149737452 1.0955338184657872 1.221268372470721 1.25460419371238 1.1196441734756524 1.1017716568743134 1.1121906492893354 1.1620454603437531 1.0200931943214724 1.0 12.082619718264619 -8.22407907902025 0.6002909804499559 0.994865235955931 1.1730805760312553 0.5451273343432768 0.05116151654002601 0.6493960380370963 0.5520062917288702 0.055039295688962285 0.026259487495131954 5.969265846101038e-09 8.22407907902025 0.17821534007532425 AVPS(ph)PPPPPIVK ddPTM_A459_Selumetinib_30min_R2 4 AVPSPPPPPIVK 12 0 A0A286YF23;A0A0J9YY01;A0A2R8YFM0;Q96JP2 A0A286YF23 MYO15B Unconventional myosin-XVB 1 AVPS(1)PPPPPIVK;AVPS(1)PPPPPIVK;AVPS(1)PPPPPIVK;AVPS(1)PPPPPIVK 92.792 0.021183 264397000.0 476773.0 421760.0 479148.0 524508.0 535719.0 407494.0 451040.0 444583.0 375721.0 441873.0 True False 450275.8653335392 454107.6358278547 448320.1393368969 453069.1055732322 468417.1898313741 463622.599637768 472014.2537188048 445876.6629253228 450875.69852187106 429114.97836606856 1.0493128602689294 1.0582423329918478 1.0447552799111217 1.0558221651883914 1.0915889993282353 1.0804157929958385 1.099971516995475 1.0390610568362757 1.0507106981878385 1.0 18.71100473403466 -8.677816717051053 1.4385024955130954 1.0006685146226855 1.0670080693486825 0.524505491853879 0.018775274747907796 0.5436689260905604 2.266708571488351 0.019470157981938106 0.005739762464271899 2.0998258748009238e-09 8.677816717051053 0.06633955472599706 AVPS(ph)PTTGEEGSVHSR ddPTM_A459_Selumetinib_30min_R1 1 AVPSPTTGEEGSVHSR 16 0 Q5SYE7-2;Q5SYE7 Q5SYE7-2 NHSL1 NHS-like protein 1 1 AVPS(0.68)PT(0.318)T(0.002)GEEGSVHSR 137.79 0.00040636 4538100.0 500.71 441.62 651.86 514.85 702.18 523.57 575.38 435.52 125.09 220.76 True False 512.3755687879413 389.9149250964318 563.3409924106749 424.94111243144886 638.667942979948 518.3033611635248 531.9786233589041 423.9685948316649 212.2685937878775 249.0966963844973 2.05693442034677 1.5653155210640457 2.2615353819912594 1.7059283346557275 2.5639358219111887 2.080731574069088 2.135630986200474 1.7020241576276918 0.8521533880972344 1.0 7.96056207790784 -8.122453360909383 3.183778418038093 0.9188124310100764 2.0465811928856956 0.739043169571733 0.2637361420757314 0.12947842525148273 2.3370317316745086 0.21181649115667633 0.06932390638997574 7.543043966054381e-09 8.122453360909383 1.1277687618756191 up AVPS(ph)PTTGEEGSVHSR ddPTM_A459_Selumetinib_30min_R2 2 AVPSPTTGEEGSVHSR 16 0 Q5SYE7-2;Q5SYE7 Q5SYE7-2 NHSL1 NHS-like protein 1 1 AVPS(0.942)PT(0.058)TGEEGSVHSR;AVPS(0.967)PT(0.026)T(0.007)GEEGSVHSR 134.33 0.00030467 22045000.0 39678.0 32426.0 55174.0 65498.0 71994.0 53612.0 39570.0 39400.0 43848.0 64784.0 True False 37472.855603618824 34912.969933976696 51624.16490890907 56577.05940964782 62949.47008547381 60996.566358719494 41410.0834064675 39514.64747697887 52618.825215484496 62913.51759095343 0.5956248678901906 0.5549359067946467 0.8205575985204856 0.8992830408481761 1.0005714589788817 0.9695303758931836 0.6582064553392896 0.6280788134259533 0.8363675602689676 1.0 15.94108240724559 -5.287827801912327 6.097602342196876 0.8434371481488357 0.5743516680755303 0.44774685565652095 0.12254422037973395 0.16788029111133385 22.602054303742417 0.03597821443701285 0.08009103486745144 5.1543297363124326e-06 5.287827801912327 -0.26908548007330546 AVPS(ph)SPAGSAAR ddPTM_A459_Selumetinib_30min_R2 3 AVPSSPAGSAAR 12 0 F8WBN8;B0QYH1;Q8IWD4-4;Q8IWD4-3;Q8IWD4 F8WBN8 CCDC117 Coiled-coil domain-containing protein 117 1 AVPS(0.499)S(0.499)PAGS(0.001)AAR;AVPS(0.636)S(0.362)PAGS(0.002)AAR;AVPS(0.5)S(0.5)PAGSAAR 155.47 0.00042631 26932300.0 108530.0 99440.0 125365.0 130957.0 148623.0 110206.0 109690.0 120439.0 97710.0 119074.0 True False 102498.33708001292 107066.72825000415 117299.15238709161 113120.43068657441 129951.65003352208 125385.87614953835 114790.80234661147 120789.45755025015 117254.73024550671 115636.02422859329 0.8863875921347024 0.9258942355052863 1.0143824398114085 0.9782455894795729 1.1237990141949983 1.084315004653491 0.9926906698183349 1.0445659850036817 1.013998284943743 1.0 16.819231386805306 -5.190053044448415 1.3850118261610276 1.0415504001026605 0.8692356684788117 0.6112005917249369 0.04104806652884213 0.44840635700445763 1.2591423184613928 0.012979641524406723 0.08755264296897837 6.4557537405854755e-06 5.190053044448415 -0.1723147316238488 AVPSS(ph)PAGSAAR ddPTM_A459_Selumetinib_30min_R1 2 AVPSSPAGSAAR 12 0 F8WBN8;B0QYH1;Q8IWD4-4;Q8IWD4-3;Q8IWD4 F8WBN8 CCDC117 Coiled-coil domain-containing protein 117 1 AVPS(0.15)S(0.85)PAGSAAR;AVPS(0.087)S(0.913)PAGSAAR 163.71 0.00050341 45416000.0 5561.9 7097.8 8069.4 8044.3 7656.4 6225.6 6340.700000000001 5781.9 4238.1 5334.700000000001 True False 5691.481448426539 6266.786276322297 6973.619802041386 6639.514015212788 6963.879971847211 6162.976116392533 5862.41589407314 5628.545229741923 7191.746161423007 6019.460709378415 0.9455135141191503 1.0410876619825005 1.1585123881905859 1.1030081158048461 1.1568943312475444 1.0238419044401301 0.9739104841965998 0.9350580561100035 1.194749248918288 1.0 12.55541852467751 -6.960824325137521 24.978605664274248 1.0174259057150465 1.0849196796616107 0.0916513171366169 0.0852666630640909 345.804041521697 220485.4370657335 0.03064586396368143 0.027027049988368853 1.0943989680471439e-07 6.960824325137521 0.0674937739465642 AVPVES(ph)PVQKV ddPTM_A459_Selumetinib_30min_R1 4 AVPVESPVQKV 11 1 Q8TB61-5;Q8TB61-4;Q8TB61-3;Q8TB61-2;Q8TB61 Q8TB61-5 SLC35B2 Adenosine 3-phospho 5-phosphosulfate transporter 1 1 AVPVES(1)PVQKV;AVPVES(1)PVQKV;AVPVES(1)PVQKV;AVPVES(1)PVQKV 151.26 0.0010758 70684100.0 21806.6 17270.4 30662.7 21441.300000000003 26985.1 20410.699999999997 21781.7 27520.699999999997 11488.0 19152.2 True False 22314.65135174279 15248.373539208873 26498.87375815481 17696.979458048805 24544.302469606344 20205.38688943282 20138.688832452714 26790.761636167772 19494.296949677322 21610.571428225998 1.0325803473478345 0.7055978871198505 1.2261995869088451 0.8189038182921173 1.1357544408820464 0.9349769836739329 0.9318906211868684 1.2397063041644436 0.9020722572941978 1.0 14.399449600093394 -5.2521124056564386 24.99842179035499 1.0224908670662214 0.8690891566672212 0.14398181252584985 0.1507608959742977 1216.5444151960296 3260600.53471514 0.03545192623584575 0.09115517732700659 5.596127417711518e-06 5.2521124056564386 -0.1534017103990002 AVPVES(ph)PVQKV ddPTM_A459_Selumetinib_30min_R2 4 AVPVESPVQKV 11 1 Q8TB61-5;Q8TB61-4;Q8TB61-3;Q8TB61-2;Q8TB61 Q8TB61-5 SLC35B2 Adenosine 3-phospho 5-phosphosulfate transporter 1 1 AVPVES(1)PVQKV;AVPVES(1)PVQKV;AVPVES(1)PVQKV;AVPVES(1)PVQKV 151.13 0.00108 60532100.0 405631.0 172362.0 352330.0 363452.0 297515.0 237206.0 408842.0 324687.0 284627.0 311834.0 True False 383087.6528895486 185581.6111688176 329661.47138789826 313949.2106103289 260138.50588215372 269878.9733583234 427853.96310505376 325631.7854151736 341560.3531428504 302830.54217796616 1.2650231714884865 0.6128232966004987 1.0886004727824454 1.0367158092852753 0.8590233468897488 0.891188092909473 1.4128494438768147 1.0752937371284292 1.1278926844245574 1.0 18.208151191076873 -7.205773426408497 24.999819465426178 1.1602851157166798 0.9480583693699358 0.20574636833689763 0.18691601442560543 424.0534831225287 190444.1494018421 0.06795099345219374 0.05263457142559653 6.22625027025772e-08 7.205773426408497 -0.212226746346744 AVQQHQHGYDS(ph)DEEVDSELGTWEHQLR ddPTM_A459_Selumetinib_30min_R1 2 AVQQHQHGYDSDEEVDSELGTWEHQLR 27 0 Q8IWZ8 Q8IWZ8 SUGP1 SURP and G-patch domain-containing protein 1 1 AVQQHQHGY(0.014)DS(0.986)DEEVDSELGTWEHQLR;AVQQHQHGY(0.02)DS(0.98)DEEVDSELGTWEHQLR 126.3 3.7317e-12 14492800.0 1166.63 1384.8600000000001 1320.31 1430.33 1349.79 947.69 1360.7800000000002 1144.6399999999999 714.77 942.9 True False 1193.8102091331841 1222.7199473960532 1141.019153943697 1180.5497161194025 1227.7017328247796 938.1570990336734 1258.1352690297363 1114.2804288852783 1212.9124852646992 1063.9303996237657 1.122075475571849 1.1492480596742416 1.0724565764331877 1.109611790899928 1.1539304951328846 0.8817842777736503 1.1825353138463255 1.047324551755752 1.1400299170825625 1.0 10.055188060123413 AVQQHQHGYDS(ph)DEEVDSELGTWEHQLR ddPTM_A459_Selumetinib_30min_R2 2 AVQQHQHGYDSDEEVDSELGTWEHQLR 27 0 Q8IWZ8 Q8IWZ8 SUGP1 SURP and G-patch domain-containing protein 1 1 AVQQHQHGY(0.033)DS(0.967)DEEVDSELGTWEHQLR;AVQQHQHGY(0.313)DS(0.687)DEEVDSELGTWEHQLR 117.01 3.253e-12 9021700.0 22688.4 20563.2 24418.4 27107.0 31005.1 20025.2 19456.7 20222.9 17451.5 22718.5 True False 21427.469556861364 22140.33131889068 22847.346728743716 23414.979837816787 27109.962148889168 22783.48952933355 20361.47510271964 20281.74529091869 20942.287635651064 22062.55787524814 0.971214202724006 1.0035251326742032 1.035571072852619 1.0612994182368092 1.2287769306796326 1.0326767031348716 0.9228973003879601 0.9192834940355065 0.9492230118587518 1.0 14.429312442464665 -7.167013910523298 5.186400239302706 0.9415354452717941 1.0620117967859208 0.38425217735302863 0.06693401397849301 0.24525824498679175 10.443077083960063 0.02837804526789473 0.021770960470160406 6.807475538890281e-08 7.167013910523298 0.12047635151412672 AVQTLAGSQPTSDKPS(ph)QRPSESTNCSPTR ddPTM_A459_Selumetinib_30min_R2 1 AVQTLAGSQPTSDKPSQRPSESTNCSPTR 29 2 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 AVQTLAGSQPT(0.016)S(0.016)DKPS(0.18)QRPS(0.18)ES(0.18)T(0.18)NCS(0.18)PT(0.068)R 51.46 0.0075131 11016000.0 11219.0 8541.4 10153.0 9058.9 10120.0 7102.5 8860.6 7829.3 7186.2 7906.9 True False 10595.492893215378 9196.497915070266 9499.767033750577 7825.0621925258565 8848.63512605211 8080.8049049243655 9272.635456945814 7852.0819667896085 8623.640799204404 7678.607252406611 1.379871706538261 1.1976778617226347 1.2371731905904138 1.0190731125196362 1.1523750121845067 1.0523789847946317 1.207593402311286 1.0225919504254664 1.1230735621361025 1.0 12.906628942970531 -1.5228787454275712 0.5810824750666187 1.083515244190926 17.302142484071947 0.6237043134069449 0.07020887165842837 98.4086702171015 0.8139319725342132 0.030694729684490697 2014.4198639560768 0.02999999998982946 1.5228787454275712 16.21862723988102 AVQTLAGSQPTSDKPSQRPSES(ph)TNCSPTR ddPTM_A459_Selumetinib_30min_R2 1 AVQTLAGSQPTSDKPSQRPSESTNCSPTR 29 2 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 AVQTLAGSQPT(0.001)S(0.003)DKPS(0.023)QRPS(0.077)ES(0.359)T(0.359)NCS(0.134)PT(0.043)R 54.3 0.0088896 3327700.0 3283.5 3794.0 3868.4 3891.0 4512.9 3644.7 3020.3 3440.3 3641.9 4136.8 True False 3101.0162148919394 4084.9876003672243 3619.5113555954617 3361.0390876506112 3945.949156162114 4146.724341707546 3160.749934610912 3450.310703427676 4370.381763188128 4017.3598353027974 0.7719040220498966 1.016833882907412 0.900967676280522 0.8366288372067826 0.9822244752603047 1.0322013739640523 0.786772921567948 0.8588503009135148 1.0878741119436524 1.0 11.97203197416516 -9.543167768049596 0.014338399444260658 1.9342952429365485 1.3496716248636038e-06 0.12702740069509588 0.09826126025494546 4271.717305687069 18.315745688276845 1300.2827868552367 1169.903952196849 2.8630717510351467e-10 9.543167768049596 -1.9342938932649236 AVS(ph)LDSPVSVGSSPPVK ddPTM_A459_Selumetinib_30min_R1 1 AVSLDSPVSVGSSPPVK 17 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 AVS(0.995)LDS(0.003)PVSVGS(0.002)SPPVK 131.4 0.00078714 3420100.0 2242.2 2845.1 2668.7 2991.3 2856.3 2081.8 2973.4 2824.5 1244.6 2061.7 True False 2294.4388974382846 2511.994369348895 2306.3051981197923 2468.9256086553255 2597.9481693207235 2060.8589821231653 2749.114044101925 2749.5850847309825 2111.9952980125686 2326.3392776586247 0.9862873053269999 1.0798056816016643 0.9913881523081207 1.0612921478677042 1.116753774597944 0.8858806632011752 1.181733924412267 1.1819364058961939 0.9078621155114633 1.0 11.183845802152897 AVS(ph)LDSPVSVGSSPPVK ddPTM_A459_Selumetinib_30min_R2 1 AVSLDSPVSVGSSPPVK 17 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 AVS(0.53)LDS(0.353)PVS(0.11)VGS(0.005)S(0.002)PPVK 144.15 0.00049453 4196100.0 45787.0 49225.0 48992.0 51448.0 53075.0 40826.0 52579.0 47763.0 47951.0 49691.0 True False 43242.341839883426 53000.39921667804 45839.90805845643 44440.69364724972 46407.24400347985 46449.410918471265 55024.027683311986 47901.98242240972 57542.539862883066 48256.29171727693 0.8960974890741886 1.0983106519497146 0.9499260392203868 0.9209305577730265 0.9616827640915666 0.9625565758473157 1.1402456700503583 0.9926577595944787 1.1924360081378038 1.0 15.558429434625525 -7.242761342310621 24.26276996943347 1.0807230046245853 0.9681528175857546 0.37089617254659446 0.07420431690540395 607.180030386453 788727.1559923098 0.02703233598707711 0.020896355095099555 5.717927674243142e-08 7.242761342310621 -0.1125701870388307 AVS(ph)MDNSNK ddPTM_A459_Selumetinib_30min_R1 2 AVSMDNSNK 9 0 O43524;O43524-2 O43524 FOXO3 Forkhead box protein O3 1 AVS(0.999)MDNS(0.001)NK;AVS(1)MDNSNK 118.9 0.007066100000000001 18726100.0 6572.7 8878.7 6936.4 6471.5 6738.400000000001 7445.1 6797.9 7261.6 4283.8 7385.599999999999 True False 6725.831121752123 7839.1776764043525 5994.474978917872 5341.374010100266 6128.912909761148 7370.209053609943 6285.128929979312 7068.998778998933 7269.295723627062 8333.61370183613 0.8070725812825034 0.9406696730707785 0.7193127967519206 0.6409433171738463 0.73544480570425 0.8843953316417916 0.7541900974597036 0.8482513147257393 0.8722861394481762 1.0 13.02472651124899 -8.585403496599783 0.9176855302671261 0.9994924117327461 0.7797396800227628 0.40890955196981926 0.08007814708866859 0.7409538795260042 1.3611747985772162 0.08365258699482832 0.0286516034852981 2.5977449151332148e-09 8.585403496599783 -0.21975273170998322 AVS(ph)MDNSNKYTK ddPTM_A459_Selumetinib_30min_R1 1 AVSMDNSNKYTK 12 1 O43524;O43524-2 O43524 FOXO3 Forkhead box protein O3 1 AVS(1)MDNSNKYTK 135.58 0.007016500000000001 6542100.0 848.24 1037.4 1746.6 1578.8 972.56 1065.0 1134.1 1024.6 709.94 920.53 True False 868.0023416122775 915.9407257258244 1509.4213133870533 1303.0922177464727 884.5921197194136 1054.2870669426316 1048.5539239308523 997.4242796301515 1204.716328033942 1038.6889922215134 0.8356710700821263 0.8818238496653756 1.4531985268841188 1.254554758455139 0.8516429136574148 1.0150170790659458 1.0094974836387165 0.9602723116347789 1.159843164850852 1.0 10.02054802692438 -5.03071348905182 24.99681442112349 1.084602860657536 0.8472088106768715 0.24773077856782788 0.1605956725991625 851.5121696678174 693022.5484707073 0.04385439114007956 0.11635346788430968 9.317223447456754e-06 5.03071348905182 -0.2373940499806645 AVS(ph)PAPQSSSR ddPTM_A459_Selumetinib_30min_R1 1 AVSPAPQSSSR 11 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 AVS(1)PAPQSSSR 123.26 0.0034144 0.0 2035.3 2827.5 2174.6 2456.8 2395.7 1925.5 1921.5 1974.3 916.39 1292.8 True False 2082.7185299956004 2496.4549855309124 1879.301264222767 2027.7659998476927 2179.0093579951867 1906.1312182141178 1776.5597079914746 1921.9351505697928 1555.0468995225278 1458.743472938386 1.4277483112231684 1.7113735429453105 1.288301403972859 1.3900771708428687 1.4937577431664184 1.306693914026259 1.2178698591966295 1.317527849292369 1.066018068543714 1.0 10.5105104853553 -7.497199897368375 0.3256222962944661 0.9612554007874752 1.5823670519609678 0.6761080514640578 0.11070324394905112 0.885359890306493 0.27454907664181455 0.15865161479641943 0.19571859219674825 3.182732234307765e-08 7.497199897368375 0.6211116511734927 AVS(ph)PAPQSSSR ddPTM_A459_Selumetinib_30min_R2 2 AVSPAPQSSSR 11 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 AVS(0.999)PAPQS(0.001)SSR;AVS(0.999)PAPQSSS(0.001)R 132.03 0.0034904000000000003 0.0 159800.0 153239.0 152740.0 163567.0 170638.0 145606.0 149803.0 134360.0 114993.0 166877.0 True False 150918.95573008442 164991.93855895408 142912.87469073778 141288.89243118672 149200.92891692487 165661.90482033344 156769.13632901307 134750.96535550448 137994.8131728746 162058.827411483 0.9312603215799323 1.0180990520190771 0.8818580078200133 0.871837064897678 0.9206590674514095 1.0222331450029678 0.9673594387485052 0.8314941401702158 0.8515106235002703 1.0 17.3061580814296 -7.745814795384878 24.997211480999955 0.8811267658776554 0.9444078725017351 0.10889660084439978 0.06277035817972287 421.4296417765919 674232.1230409226 0.030603808050172474 0.01759085230725957 1.7954991531031055e-08 7.745814795384878 0.06328110662407971 AVS(ph)PAVPFSR ddPTM_A459_Selumetinib_30min_R1 3 AVSPAVPFSR 10 0 I3L2J0 I3L2J0 CIC 1 AVS(1)PAVPFSR;AVS(1)PAVPFSR;AVS(1)PAVPFSR 121.29 0.004823600000000001 94327000.0 14138.4 14617.7 16152.300000000001 16323.3 14862.6 12157.7 13125.899999999998 13427.2 8322.2 11138.4 True False 14467.797211462585 12906.252888415636 13958.906378232976 13472.74208129022 13518.280454205149 12035.404576308383 12135.802795277279 13071.0670383076 14122.16557056099 12568.122137203687 1.151150271577609 1.0269038403287813 1.1106596694276498 1.071977335532785 1.0756006590824605 0.9576135913480366 0.9656019143347857 1.0400175058464076 1.1236496125986142 1.0 13.617481485494855 -6.574951356141382 14.921133859083614 1.0166253320398573 1.0854515440551338 0.3133425312184266 0.05188904583810994 2.9759995930262955 851.1161727210036 0.017642241196599073 0.01764211480374943 2.66102309532007e-07 6.574951356141382 0.0688262120152765 AVS(ph)PAVPFSR ddPTM_A459_Selumetinib_30min_R2 2 AVSPAVPFSR 10 0 I3L2J0 I3L2J0 CIC 1 AVS(0.997)PAVPFS(0.003)R;AVS(1)PAVPFSR 110.93 0.0091576 103566000.0 636550.0 593470.0 605810.0 636010.0 633150.0 435680.0 387240.0 483930.0 396610.0 554040.0 True False 601173.0993115467 638987.2406931814 566832.8441560549 549384.3408215523 553608.036567183 495690.9652907362 405247.4273015033 485338.15618107596 475943.0822092988 538043.425631203 1.1173319302364553 1.187612765537571 1.0535076113811404 1.0210780666579928 1.0289281686096627 0.9212843084351765 0.753187211285203 0.9020427219451737 0.8845811686128281 1.0 19.037363092227018 -6.226283822047804 1.009564250037584 0.8755071849251903 1.1437971287878956 0.6822127700162857 0.0670426065263197 0.30348461128178544 0.6493046035324291 0.030935789837973543 0.05000903774950857 5.939039010611949e-07 6.226283822047804 0.2682899438627053 AVS(ph)PPHLDGPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 AVSPPHLDGPPSPR 14 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BVD2;H3BT57;H3BUJ5;H3BRN3 P29590-2 PML Protein PML 2 AVS(1)PPHLDGPPS(1)PR 99.409 0.038782 21161000.0 25527.0 23893.0 23078.0 26839.0 31126.0 23537.0 23021.0 34063.0 25473.0 21780.0 True False 24108.31153267748 25725.516271896166 21593.186605426537 23183.48190014258 27215.673610029455 26779.00810238718 24091.52211524609 34162.117690566796 30568.31177508751 21151.15480876398 1.1398106510330208 1.2162700573321321 1.020898707453997 1.0960858690579158 1.2867228222807316 1.2660778262230534 1.1390168684909712 1.6151419626701293 1.4452313384998503 1.0 14.368448813173401 -6.800174507899715 1.176271968821666 1.3555520375708316 1.1231557790579403 0.17160210505170492 0.16528336292308204 0.6838031628582936 1.9956515056593649 0.08692720048486229 0.07553076286381588 1.5842564797364733e-07 6.800174507899715 -0.23239625851289136 AVS(ph)PPHLDGPPSPR ddPTM_A459_Selumetinib_30min_R2 1 AVSPPHLDGPPSPR 14 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BVD2;H3BT57;H3BUJ5;H3BRN3 P29590-2 PML Protein PML 1 AVS(1)PPHLDGPPSPR 77.051 0.027094 5413600.0 17766.0 16617.0 15919.0 15933.0 18368.0 15962.0 13613.0 12519.0 12798.0 15568.0 True False 16778.6368429329 17891.470467923595 14894.788871296703 13762.897914041943 16060.447627996555 18160.620611390757 14246.031473647758 12555.42821736798 15357.95760599733 15118.511389478324 1.1098074678575787 1.1834148222010206 0.9852020802565707 0.9103341962370836 1.0623035042440598 1.201217510344939 0.9422906201970542 0.8304672261652617 1.0158379492762526 1.0 13.884028474350245 -7.4796779990877 24.408795974300354 0.9311673119810118 1.0684001122910491 0.3065593317632561 0.09304562958169585 440.3544319785099 248804.4848137608 0.04146377547568787 0.02795228238096296 3.3137672455832365e-08 7.4796779990877 0.13723280031003737 AVS(ph)PSNPK ddPTM_A459_Selumetinib_30min_R1 3 AVSPSNPK 8 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 AVS(0.795)PS(0.205)NPK;AVS(0.707)PS(0.293)NPK;AVS(0.795)PS(0.205)NPK 95.775 0.021615 669016000.0 20121.800000000003 27176.6 26708.5 29567.8 23761.4 25644.7 25580.6 22518.3 14900.7 18847.4 True False 20590.598789792897 23994.751037941413 23081.63239928897 24404.338786346703 21612.185565415908 25386.737601524597 23651.03474694079 21921.041534253032 25285.399595931132 21266.647379222573 0.9682108525441498 1.1282808526455461 1.0853442006020955 1.1475404821067208 1.0162478918294815 1.1937348256560334 1.1121186299467096 1.0307709129399398 1.1889697113535096 1.0 14.376304994389947 -4.754797696759903 24.8681817538415 1.1029618603931202 0.968210608060162 0.2714896432345757 0.06480093385091194 266.37965567435504 997297.3094829884 0.014828169522932248 0.13848594227194688 1.758742681437879e-05 4.754797696759903 -0.13475125233295815 AVS(ph)PSNPK ddPTM_A459_Selumetinib_30min_R2 4 AVSPSNPK 8 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 AVS(0.733)PS(0.267)NPK;AVS(0.907)PS(0.093)NPK;AVS(0.738)PS(0.262)NPK;AVS(0.757)PS(0.243)NPK 91.265 0.027107 681897000.0 1256280.0 1163230.0 870519.0 1047103.0 1010033.0 748928.0 1499190.0 1371850.0 1033560.0 1265340.0 True False 1186460.9868873 1252446.0006260313 814510.755289424 904485.7650465748 883143.6247304141 852086.0339085105 1568905.305588626 1375841.8563780063 1240300.8800792748 1228806.3464518548 0.9655394361472611 1.0192379004571674 0.66284712610844 0.7360685983257272 0.718700409776095 0.6934258081990591 1.2767718120261975 1.1196571863017413 1.0093542271006413 1.0 20.228826141644134 -7.254479278076176 24.990114156607103 1.1114172409001355 0.7965596273485923 0.5675317899374154 0.12908035061554773 423.97129808118837 1522264.1128823734 0.05417723524962316 0.041030223418410255 5.5657118985851435e-08 7.254479278076176 -0.3148576135515432 AVS(ph)VSSMSEFQR ddPTM_A459_Selumetinib_30min_R1 1 AVSVSSMSEFQR 12 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 AVS(0.703)VS(0.281)S(0.015)MSEFQR 96.756 0.016828 13085000.0 2750.5 3115.2 3668.3 3555.4 3501.7 3337.8 3293.5 3195.7 2031.7 2813.3 True False 2814.5812984586573 2750.4709357828087 3170.1650085295596 2934.516133123771 3184.9718532753463 3304.22476247992 3045.068643387936 3110.9396549034514 3447.6465105030848 3174.414458862596 0.8866458160813481 0.8664498512800727 0.9986613435680485 0.9244275349524519 1.003325776942351 1.0408926765233535 0.9592536459397917 0.9800042480962339 1.0860732129283424 1.0 11.632274786719856 -5.061425522163029 0.626601546246758 1.014225287147066 0.8037499596026965 0.5714770372294375 0.041959167500584614 1.9242199167510459 0.7259333973240887 0.02126499181526274 0.2770428309815999 8.681094379671472e-06 5.061425522163029 -0.2104753275443696 AVS(ph)VSSMSEFQR ddPTM_A459_Selumetinib_30min_R2 1 AVSVSSMSEFQR 12 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 AVS(0.829)VS(0.032)S(0.069)MS(0.069)EFQR 112.5 0.0063518 6729200.0 27013.0 14022.0 25872.0 24099.0 29620.0 19020.0 19320.0 27033.0 18574.0 21049.0 True False 25511.725601606817 15097.442312163726 24207.423687303733 20816.674626906206 25898.87079384028 21639.83235363062 20218.418281853727 27111.661554445942 22289.31900092156 20441.260678130086 1.2480504995908386 0.7385768691026156 1.1842431867816758 1.018365498815725 1.2669898986000037 1.0586349195567413 0.9890984025014281 1.3263204252099996 1.0904082361597538 1.0 14.31919655420074 AVSEGCAS(ph)EDEVEGEA ddPTM_A459_Selumetinib_30min_R2 1 AVSEGCASEDEVEGEA 16 0 Q9BYX2-6;Q9BYX2-5;Q9BYX2-4;Q9BYX2-2;Q9BYX2 Q9BYX2-6 TBC1D2 TBC1 domain family member 2A 1 AVS(0.002)EGCAS(0.998)EDEVEGEA 100.73 0.0086083 0.0 8527.9 8635.1 10149.0 10571.0 12503.0 7954.9 8732.5 8393.7 7381.2 8968.7 True False 8053.953457888528 9297.38440377728 9496.024389395703 9131.21156400787 10932.26136176181 9050.615267607582 9138.578553120482 8418.124277348164 8857.64624795964 8709.750327518897 0.9247054341433478 1.067468532869619 1.0902751551204095 1.0483895887528882 1.2551750567660678 1.0391360173679955 1.0492354211631854 0.9665172893361449 1.0169805005745638 1.0 13.088415647985306 -7.485228898654274 2.710428890107746 0.9946517748934164 1.078736968374834 0.15705378918390178 0.07693954966360267 0.5048498912825907 7.377988574729303 0.04104978594445888 0.02339408596163195 3.271682125990642e-08 7.485228898654274 0.08408519348141763 AVSETPAVPPVS(ph)EDEDDDDDDATPPPVIAPRPEHTK ddPTM_A459_Selumetinib_30min_R1 1 AVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTK 36 1 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 AVSETPAVPPVS(1)EDEDDDDDDATPPPVIAPRPEHTK 100.14 2.6677999999999997e-14 5804600.0 1472.8 1775.3 1740.1 1917.3 1886.4 1222.2 1562.0 1615.6 838.39 1031.0 True False 1507.1133744300703 1567.4470506854213 1503.8039776851094 1582.479547178435 1715.7754530709703 1209.9057776688105 1444.1770824265855 1572.7490397915997 1422.686596417129 1163.3388927904373 1.295506738208537 1.3473692493213838 1.2926619981543102 1.360291104325265 1.4748715646869106 1.04002864957663 1.2414070322728719 1.35192681130013 1.2229339234112673 1.0 10.184055714858978 -6.7537267522318025 24.999989982450217 1.1976389380412666 1.3506902146012698 0.4164609634028512 0.10592411652883793 212.84889914914052 689935.2690121953 0.03573912381102976 0.035091418123175074 1.7630849886949925e-07 6.7537267522318025 0.15305127656000317 AVSETPAVPPVS(ph)EDEDDDDDDATPPPVIAPRPEHTK ddPTM_A459_Selumetinib_30min_R2 2 AVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTK 36 1 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 AVS(0.001)ET(0.006)PAVPPVS(0.992)EDEDDDDDDAT(0.001)PPPVIAPRPEHTK;AVS(0.017)ET(0.095)PAVPPVS(0.706)EDEDDDDDDAT(0.182)PPPVIAPRPEHTK 86.324 1.6986e-09 10475700.0 65956.0 55100.0 60502.0 72019.0 64341.0 56625.0 51862.0 54856.0 47878.0 59314.0 True False 62290.42956278755 59325.992825575595 56609.367189596844 62209.88796029532 56257.908364161915 64424.57975942869 54273.6857626034 55015.62187810033 57454.93782309264 57601.450703720286 1.0814038327469488 1.0299392133494292 0.982776761661328 1.0800055762532625 0.9766751996148667 1.1184541182964984 0.9422277581473837 0.9551082690795331 0.9974564376619393 1.0 15.81381752622932 -7.293513512340695 24.998411507422926 0.9699571358151305 1.0398709755670559 0.37988506122443066 0.04417167662883294 710.1488983856601 553483.8213033221 0.017581827160547698 0.011854977384093053 5.087289911534809e-08 7.293513512340695 0.06991383975192533 AVSGYQSHDDS(ph)SDNSECSFPFK ddPTM_A459_Selumetinib_30min_R1 1 AVSGYQSHDDSSDNSECSFPFK 22 0 Q9UBW7 Q9UBW7 ZMYM2 Zinc finger MYM-type protein 2 1 AVS(0.001)GY(0.005)QS(0.042)HDDS(0.677)S(0.253)DNS(0.021)ECSFPFK 73.346 0.0016132000000000002 3726000.0 1349.7 1793.0 1896.7 1800.2 1985.1 1743.5 1539.6 1559.0 681.68 1044.8 True False 1381.1453839409737 1583.074726456915 1639.138557827335 1485.8288639391944 1805.5480554978697 1725.96197297134 1423.4667324609284 1517.6502556543112 1156.761172062677 1178.9102572138195 1.1715441234730684 1.3428288682450509 1.3903845078939234 1.260340941854838 1.5315398644210767 1.4640316872383454 1.2074428259069372 1.2873331505665697 0.981212238153319 1.0 10.203238184149937 -8.135121730144977 1.7535860041889526 0.9742613619024818 1.3547211900292129 0.6236270336430585 0.10550388299309557 0.24014055764042408 1.3195038257435612 0.09852540403373725 0.030568323952296764 7.326191555910069e-09 8.135121730144977 0.38045982812673107 AVSGYQSHDDS(ph)SDNSECSFPFK ddPTM_A459_Selumetinib_30min_R2 2 AVSGYQSHDDSSDNSECSFPFK 22 0 Q9UBW7 Q9UBW7 ZMYM2 Zinc finger MYM-type protein 2 1 AVS(0.009)GY(0.007)QS(0.021)HDDS(0.444)S(0.444)DNS(0.076)ECSFPFK;AVS(0.003)GY(0.002)QS(0.053)HDDS(0.778)S(0.163)DNS(0.002)ECSFPFK 88.98299999999998 0.0016747 0.0 16686.1 15074.3 18987.7 19190.5 21573.2 15355.8 15835.599999999999 17853.7 15084.7 16321.5 True False 15758.753361750694 16230.450338485924 17766.05205424464 16576.720794541015 18862.981749145012 17470.92206392645 16571.986777646107 17905.651311160866 18102.06150173369 15850.2558866502 0.9942270632377251 1.0239866444147403 1.120868469335439 1.0458330081915381 1.1900742728722926 1.1022485812762965 1.045534336868579 1.1296758512423646 1.1420674613196662 1.0 13.952218510981725 -5.133286722908613 3.9221917978468817 1.1014772507184283 0.9996886293372508 0.31376886297581974 0.05229264171559158 0.2510949150688328 6.53706429529674 0.013084130424218016 0.04094643343697672 7.357212111109921e-06 5.133286722908613 -0.1017886213811775 AVSISYTVMTPMLNPMIY(ph)T(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 AVSISYTVMTPMLNPMIYTLR 21 0 Q15615 Q15615 OR4D1 Olfactory receptor 4D1 2 AVSISYTVMTPMLNPMIY(1)T(1)LR 64.331 0.019756 0.0 569.81 558.09 740.78 754.04 550.0 594.75 503.71 533.02 324.29 298.03 True False 583.0854643427471 492.7485633509982 640.1861448132721 622.3610690838299 500.25259711038666 588.7673549897937 465.7147491607526 518.8825781070308 550.2964447955136 336.28505355803475 1.7339024086068116 1.465270484481885 1.9037008574714764 1.85069500561798 1.4875849872526525 1.750798463269158 1.3848809045578987 1.5429843598965782 1.636398760435975 1.0 8.39354084839869 -12.123452563365822 0.22315124507241463 8.384751586941371e-10 1.7448669100880696 0.6242213423536354 0.15404074792874559 30.295983383191416 0.785323350520727 15.004066159823138 0.3122194854019063 7.52570926663825e-13 12.123452563365822 1.7448669092495945 AVSLDSPVS(ph)VGSSPPVK ddPTM_A459_Selumetinib_30min_R2 1 AVSLDSPVSVGSSPPVK 17 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 AVS(0.002)LDS(0.172)PVS(0.684)VGS(0.132)S(0.009)PPVK 115.8 0.0016469000000000002 2809900.0 16212.0 17327.0 15444.0 19184.0 19572.0 14712.0 13353.0 15121.0 12368.0 14781.0 True False 15311.001941778026 18655.92518491377 14450.349854155793 16571.10610575413 17113.190384100002 16738.444457760976 13973.940958467532 15164.999606583691 14841.945590793483 14354.234124349878 1.066654048494662 1.2996809877349496 1.0066959845417924 1.1544402830690668 1.1922050480610424 1.1660980525158517 0.9735065512664843 1.056482670911607 1.0339768365360764 1.0 13.809188736602472 -7.2527389590907845 24.778527414273015 1.0206984032199726 1.1504702556520998 0.42503005748884093 0.07488267644947674 552.1078071097536 1572388.7462483135 0.027935142708481582 0.021266733072961282 5.588059747092795e-08 7.2527389590907845 0.1297718524321272 AVSLDSPVSVGSS(ph)PPVK ddPTM_A459_Selumetinib_30min_R1 3 AVSLDSPVSVGSSPPVK 17 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 AVSLDSPVS(0.001)VGS(0.225)S(0.774)PPVK;AVSLDSPVSVGS(0.074)S(0.926)PPVK;AVSLDSPVSVGS(0.238)S(0.762)PPVK 256.35 5.562199999999997e-94 35534000.0 8897.7 9840.9 9975.8 10639.900000000001 9516.5 8749.7 9030.8 8465.3 5663.0 8146.4 True False 9104.99909808965 8688.72285308971 8621.141153147011 8781.841200659179 8655.734255274536 8661.685962091964 8349.599485261211 8240.772744830294 9609.697390844589 9192.06979265569 0.990527629083538 0.9452411751738281 0.9378890008031879 0.9553714667914862 0.9416523645403915 0.9422998473110492 0.908348138515267 0.8965089398488395 1.0454334668479754 1.0 13.166174036642632 -8.270065531080398 24.998963423625284 1.0227167411196105 0.9394772556628616 0.6199514553061456 0.02598963475844081 465.85423496208944 1350048.6882690175 0.024385164342556605 0.006695426551070889 5.369507692784351e-09 8.270065531080398 -0.08323948545674897 AVSLDSPVSVGSS(ph)PPVK ddPTM_A459_Selumetinib_30min_R2 3 AVSLDSPVSVGSSPPVK 17 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 AVSLDS(0.003)PVS(0.013)VGS(0.282)S(0.702)PPVK;AVSLDSPVSVGS(0.021)S(0.979)PPVK;AVSLDSPVSVGS(0.02)S(0.98)PPVK 274.02 5.4914e-52 76090000.0 78735.0 88450.0 85377.0 90491.0 88430.0 77700.0 77466.0 74564.0 67148.0 86674.0 True False 74359.22390117768 95233.83058842403 79883.93677144915 78165.96969431818 77320.63282576967 88402.46970962678 81068.32249596683 74780.96889526535 80579.47627187887 84171.49641390308 0.8834252338288636 1.1314261317171228 0.9490616203213215 0.9286513015040928 0.9186082714456553 1.0502661052254365 0.96313272247559 0.888435777921056 0.9573249817924006 1.0 16.3610441455699 AVSLLTS(ph)PAAGIK ddPTM_A459_Selumetinib_30min_R2 1 AVSLLTSPAAGIK 13 0 Q8TC05-4;Q8TC05;H0YGX6 Q8TC05-4 MDM1 Nuclear protein MDM1 1 AVSLLT(0.139)S(0.86)PAAGIK 176.99 0.00010276 3292200.0 76177.0 74308.0 76871.0 89182.0 87222.0 64726.0 65945.0 64836.0 63903.0 78575.0 True False 71943.38730069237 80007.18466212104 71925.20355081651 77035.25775246909 76264.39258542666 73641.41897587267 69011.57316753852 65024.662025822414 76685.38559900346 76306.3355876324 0.9428232498213794 1.048499892518603 0.9425849504752528 1.0095525772430727 0.9994503339482528 0.9650760766948471 0.9044016153584472 0.8521528589345797 1.0049674775816715 1.0 16.21951522614261 -7.030390455614954 4.799686820606182 0.9283489575270794 0.9900829911370477 0.15031348268165856 0.05076448382045529 0.2862788991286842 16.532069477330595 0.018598638172869494 0.01490855043804655 9.324156287887748e-08 7.030390455614954 0.06173403360996832 AVSPPHLDGPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 AVSPPHLDGPPSPR 14 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BVD2;H3BT57;H3BUJ5;H3BRN3 P29590-2 PML Protein PML 1 AVSPPHLDGPPS(1)PR;AVSPPHLDGPPS(1)PR;AVSPPHLDGPPS(1)PR;AVSPPHLDGPPS(1)PR 158.45 0.00020219 39304200.0 12136.71 12876.2 13075.099999999999 13205.47 14982.9 11182.599999999999 12849.240000000002 12427.7 5812.21 10696.41 True False 12419.471729073312 11368.648518017028 11299.573236383294 10899.382561872631 13627.699340445846 11070.113196988415 11880.01148181753 12098.077025141169 9862.895862977373 12069.398415356496 1.0290050341922097 0.941939948187652 0.9362167729922881 0.903059306419515 1.129111731294465 0.9172050516538885 0.9843085026261127 1.0023761424387303 0.8171820602448852 1.0 13.559066148035814 AVSPPHLDGPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 AVSPPHLDGPPSPR 14 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BVD2;H3BT57;H3BUJ5;H3BRN3 P29590-2 PML Protein PML 1 AVSPPHLDGPPS(1)PR;AVSPPHLDGPPS(1)PR;AVSPPHLDGPPS(1)PR 127.88 0.00078059 51733000.0 110672.0 91650.0 114937.0 125845.0 132915.0 105588.0 99267.0 98884.0 102345.0 105902.0 True False 104521.29329511823 98679.2602988025 107542.07855394334 108704.69390526607 116217.02942482379 120131.78856756835 103883.11219382899 99171.73606887253 122816.85975822779 102844.3340935596 1.0163058005707253 0.9595011836921609 1.0456782038776204 1.0569828164415473 1.130028508124704 1.168093406665281 1.0101004893407584 0.9642897388849245 1.1942015166970577 1.0 16.650102789444183 -5.510345369159061 2.8983172780651456 1.0767888929378775 0.9881866621360622 0.1881530218165981 0.0708159891060508 0.435858202279207 7.342096907962066 0.02018686516571764 0.04452032817459332 3.0878388770799732e-06 5.510345369159061 -0.08860223080181528 AVSTVVVTTAPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AVSTVVVTTAPSPK 14 0 Q6P4R8-3;Q6P4R8;Q6P4R8-2 Q6P4R8-3 NFRKB Nuclear factor related to kappa-B-binding protein 1 AVSTVVVT(0.002)T(0.216)APS(0.782)PK 222.27 5.1944e-09 27589000.0 5062.9 6507.7 7100.7 8006.3 4965.6 5151.1 5216.5 5127.7 4056.3 5716.2 True False 5180.85571931152 5745.775458652348 6136.46394135317 6608.150001864449 4516.462356747883 5099.284610824588 4823.015205171757 4991.696738883008 6883.244839569647 6449.929950503096 0.8032421683753964 0.8908275752985777 0.9514000909226192 1.0245305069319415 0.7002343267922775 0.7905953475396802 0.7477624163647794 0.773914876159803 1.0671813325713333 1.0 12.655067776886261 -8.26699276728302 24.99341036434205 1.033590692182584 0.8384290720653206 0.4181903350583216 0.09349062497875124 536.5461038201114 2414723.970700184 0.08994900899232985 0.02582613013367704 5.40763328714028e-09 8.26699276728302 -0.19516162011726335 AVSTVVVTTAPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 AVSTVVVTTAPSPK 14 0 Q6P4R8-3;Q6P4R8;Q6P4R8-2 Q6P4R8-3 NFRKB Nuclear factor related to kappa-B-binding protein 1 AVSTVVVT(0.01)T(0.321)APS(0.669)PK;AVSTVVVT(0.012)T(0.383)APS(0.605)PK;AVSTVVVT(0.003)T(0.013)APS(0.984)PK;AVSTVVVT(0.001)T(0.043)APS(0.957)PK 195.6 7.0373e-15 29589200.0 199272.0 181616.0 188525.0 177080.0 163512.0 126273.0 166949.0 150186.0 112017.0 154672.0 True False 188197.2599890199 195545.36321251813 176395.50675050018 152961.39851996157 142970.16074417325 143665.95955783388 174712.4593031675 150623.01639536917 134423.53001648712 150206.2174738814 1.2529258985018017 1.3018459987950932 1.174355560755484 1.0183426564653306 0.9518258508109599 0.9564581411739179 1.163150648764239 1.0027748446668676 0.8949265368449967 1.0 17.196585005884785 -5.627177709913481 2.7418578829885445 0.9996843387449579 1.2752261051277192 0.7531543021923368 0.06597807754167416 0.13585054852261422 2.0489531751026937 0.01998114804167115 0.039907183803346756 2.35951254149504e-06 5.627177709913481 0.2755417663827613 AVSVSS(ph)MSEFQR ddPTM_A459_Selumetinib_30min_R2 1 AVSVSSMSEFQR 12 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 AVS(0.306)VS(0.087)S(0.478)MS(0.129)EFQR 103.46 0.010673 5332800.0 21129.0 16966.0 19570.0 20809.0 13667.0 14639.0 18082.0 16687.0 12070.0 18879.0 True False 19954.734766088564 18267.237645711717 18310.887506204923 17974.778302472776 11950.029275469784 16655.389370389003 18922.848828803264 16735.556407318443 14484.337263977784 18333.914216467187 1.0884055925256586 0.9963632113705658 0.9987440374166482 0.9804113889836006 0.6517991267100228 0.9084470001190164 1.0321226883349932 0.9128196090438163 0.7900297281290984 1.0 14.16222720786234 -6.016929008127635 24.50948588860806 0.8805115603942743 1.0188381518460625 0.29538690701702297 0.10263161530154871 772.5233780382621 1118445.8760260479 0.031225722302163163 0.041374437896753206 9.61769481016623e-07 6.016929008127635 0.13832659145178827 AVT(ph)PSSEAK ddPTM_A459_Selumetinib_30min_R1 1 AVTPSSEAK 9 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5 Q99700 ATXN2 Ataxin-2 1 AVT(0.902)PS(0.076)S(0.022)EAK 105.17 0.032518 94235000.0 8413.4 10098.0 9935.8 9878.2 8737.3 8322.2 8124.9 8075.5 4946.2 6742.6 True False 8609.41585037341 8915.721465567163 8586.572933442738 8153.157806779334 7947.012757695599 8238.486223953021 7512.032251605482 7861.311507079148 8393.34014384523 7608.078388485745 1.1316150295458463 1.171875605154179 1.1286125740289257 1.0716448215253047 1.0445492740614775 1.0828603233664562 0.9873757692841834 1.0332847672779835 1.1032142040686541 1.0 12.893316395489512 -5.801703097803569 2.038237177378567 1.0424266149322927 1.153482946912611 0.6554895251379711 0.03335892122317908 0.19450288929281231 1.650386249373847 0.010222867174470346 0.019262966784302053 1.5786901606705986e-06 5.801703097803569 0.11105633198031839 AVT(ph)PSSEAK ddPTM_A459_Selumetinib_30min_R2 2 AVTPSSEAK 9 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5 Q99700 ATXN2 Ataxin-2 1 AVT(0.89)PS(0.087)S(0.023)EAK;AVT(0.491)PS(0.491)S(0.018)EAK 107.55 0.029282 438620000.0 2150320.0 1886860.0 1822880.0 2061040.0 1932740.0 1504170.0 1740250.0 1724480.0 1424290.0 1894380.0 True False 2030813.822812986 2031576.0947888535 1705597.8854016778 1780322.796507691 1689931.9222851733 1711355.7640042363 1821175.0732399563 1729497.9512969668 1709187.7979876527 1839684.3272096599 1.1038925498121854 1.1043068991462495 0.9271144294568419 0.9677327627223931 0.918598858124957 0.9302442482618386 0.9899388967466078 0.9401058245248965 0.9290658036860391 1.0 20.811026803736993 -5.256706719389371 24.99108961413819 0.9483936793910339 1.104099745528523 0.8460727039577418 0.026221174497600648 128.3292352574168 677644.5021984603 0.006499962845445739 0.016060662917357117 5.537239147174659e-06 5.256706719389371 0.15570606613748916 AVT(ph)PSSEAKDSR ddPTM_A459_Selumetinib_30min_R1 1 AVTPSSEAKDSR 12 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5 Q99700 ATXN2 Ataxin-2 1 AVT(0.899)PS(0.099)S(0.002)EAKDSR 123.28 0.034581 5528800.0 689.01 561.17 4338.5 3597.7 1611.0 1156.4 980.7 730.82 596.26 447.71 True False 705.062592419923 495.4679555191445 3749.355529674645 2969.429232193112 1465.2853344451507 1144.7676659271908 906.7250094338999 711.4362795620804 1011.8096708926362 505.17793956470047 1.3956717766168854 0.9807790814184744 7.4218512647353 5.877986744139693 2.900533098709242 2.266068203440572 1.7948626383313626 1.4082884937040356 2.0028777815683876 1.0 8.98064782974044 -6.693041082322901 2.897719044423133 1.6718714212297023 3.9824673439552076 0.2527662913711951 1.795523198035612 0.4157894295718154 7.0906159280528405 0.7199547059878217 0.6958981482367753 2.0274909188426526e-07 6.693041082322901 2.310595922725505 AVT(ph)PVPTKTEEVSNLK ddPTM_A459_Selumetinib_30min_R1 2 AVTPVPTKTEEVSNLK 16 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1 Q6PKG0 LARP1 La-related protein 1 1 AVT(0.959)PVPT(0.02)KT(0.005)EEVS(0.016)NLK;AVT(0.999)PVPT(0.001)KTEEVSNLK 131.61 0.0071363 191346700.0 5309.2 5172.3 9604.3 9547.8 7375.700000000001 5617.2 5713.7 5479.6 2984.8399999999997 3890.5 True False 5432.894030095143 4566.724711462967 8300.08881264358 7880.455964403201 6708.569237285601 5560.696068009528 5282.711008873742 5334.263207750712 5065.055475911808 4389.883571679139 1.2375941050338721 1.0402837881452482 1.8907309674886845 1.7951400841797065 1.5281884195210125 1.266706958672836 1.2033829423073046 1.2151263514513544 1.153801779297398 1.0 12.099966961828516 -6.895745509010491 3.3783546554051105 1.166954972671081 1.5113022367680646 0.33671067342559846 0.23542558846878278 0.3390189800144015 7.6197066036495515 0.09866506259619069 0.08567587156991212 1.2713188635065146e-07 6.895745509010491 0.3443472640969836 AVT(ph)PVPTKTEEVSNLK ddPTM_A459_Selumetinib_30min_R2 4 AVTPVPTKTEEVSNLK 16 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1 Q6PKG0 LARP1 La-related protein 1 1 AVT(0.992)PVPT(0.004)KT(0.004)EEVSNLK;AVT(1)PVPTKTEEVSNLK;AVT(0.999)PVPT(0.001)KTEEVSNLK;AVT(1)PVPTKTEEVSNLK 169.64 0.00011407 223356000.0 398614.0 473103.0 460371.0 472266.0 440258.0 248816.0 236542.0 239829.0 182931.0 408383.0 True False 376460.6296582715 509388.47883408965 430751.23107404594 407942.55609570834 384948.8540835424 283088.14547323616 247541.6716990812 240526.8626841717 219522.31151919824 396591.92168353783 0.9492392786524528 1.2844146614780476 1.0861321361400944 1.0286204377638024 0.9706421967684807 0.7138020973082945 0.6241722490167314 0.6064845235957709 0.5535218937070709 1.0 18.597295765554264 -6.626980335879154 1.8242618919832008 0.6581280677786076 1.108660917801914 0.6341736276959837 0.13924091062246605 0.1958812178710331 1.336287809273207 0.052402052815847644 0.0528800596006099 2.3605851140690442e-07 6.626980335879154 0.45053285002330645 AVT(ph)PVSQGSNSSSADPK ddPTM_A459_Selumetinib_30min_R1 2 AVTPVSQGSNSSSADPK 17 0 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 AVT(0.999)PVS(0.001)QGSNSSSADPK;AVT(0.999)PVS(0.001)QGSNSSSADPK 254.02 1.4081e-30 17847600.0 12132.099999999999 14230.099999999999 15085.6 15838.2 13072.8 11723.1 12657.5 11005.0 6631.8 11450.5 True False 12414.754325042819 12564.03327660599 13037.058379269287 13072.355689835442 11890.367548190294 11605.17625772315 11702.73458438829 10713.11165072206 11253.680232492177 12920.283212315118 0.9608732348227128 0.9724270799753394 1.0090381274957552 1.0117700575924973 0.9202869126627853 0.8982137672231163 0.9057645557826235 0.8291700324734935 0.8710087888604177 1.0 13.65735007377048 -6.439421903917184 3.6489680051810116 0.8914120999193436 0.9885377167390736 0.47786478323139914 0.042936786725079466 0.19395467901436841 4.872170446834746 0.013950022035042888 0.015611668636316096 3.635616753744304e-07 6.439421903917184 0.09712561681973009 AVT(ph)PVSQGSNSSSADPK ddPTM_A459_Selumetinib_30min_R2 1 AVTPVSQGSNSSSADPK 17 0 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 AVT(0.887)PVS(0.08)QGS(0.014)NS(0.014)S(0.003)S(0.001)ADPK 85.176 0.027758 9253500.0 62257.0 58980.0 65545.0 68828.0 68939.0 46068.0 56894.0 53930.0 46319.0 59928.0 True False 58797.00517451727 63503.57634940924 61327.906060000074 59453.50766507738 60278.26649752033 52413.4488363331 59539.68373332224 54086.927371407866 55584.09426099313 58197.72292835667 1.0102973486934932 1.0911694333399307 1.0537853196678633 1.0215779015661253 1.035749569991336 0.9006099585864518 1.023058647958058 0.9293650103456912 0.9550905338584982 1.0 15.828675086218501 -6.62724939920534 8.405157738971182 0.9611759658165362 1.0457981625793566 0.5388819001948908 0.03745770845801418 0.1888966093787781 13.764353997211737 0.01187545159482386 0.011866300587673103 2.359123087265144e-07 6.62724939920534 0.08462219676282046 AVTELNEPLSNEDR ddPTM_A459_Selumetinib_30min_R2 1 AVTELNEPLSNEDR 14 0 Q04917 Q04917 YWHAH 14-3-3 protein eta 0 124.6 0.0202 3876400.0 5494.3 8125.6 11523.0 9969.5 9209.1 7831.1 7821.9 6770.9 6738.2 8391.0 False True 5188.948801425548 8748.807392077993 10781.622725293793 8611.636901653246 8052.170527601431 8909.762941352088 8185.633848800813 6790.602198017163 8086.028281038529 8148.730027563757 0.6367800606810505 1.073640599514823 1.3231046664724513 1.056807241438073 0.988150362125668 1.0933928245523012 1.0045287819221187 0.8333325775976608 0.9923053351487735 1.0 12.99235951876648 -7.534064890184113 23.92938238602924 0.9314774536952959 1.0439688324412657 0.04737155902963264 0.16381421429120713 367.63199305316687 786419.3023729499 0.07899837895436099 0.04567181104604897 2.92371549775595e-08 7.534064890184113 0.11249137874596982 AVTEQGAELSNEER ddPTM_A459_Selumetinib_30min_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 238.07 2.9251e-18 13172000.0 893.48 1016.5 1175.1 1016.1 974.97 1177.1 1105.0 937.51 598.25 816.85 False True 914.296345590562 897.4877074419702 1015.5278743622613 838.6572095592805 886.7841356449337 1165.259442721288 1021.6489603593958 912.6441893383401 1015.186555548787 921.7006542927915 0.991966688243364 0.9737301403247896 1.1017979315002897 0.9099019357893057 0.9621172899408987 1.2642493387567093 1.1084390095646546 0.9901741797488467 1.1014276173295396 1.0 9.848154464627596 AVTEQGAELSNEER ddPTM_A459_Selumetinib_30min_R2 2 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 ; 300.27 7.559499999999997e-79 44942000.0 58364.0 46193.0 57051.0 57733.0 58576.0 41687.0 44010.0 49971.0 42834.0 52308.0 False True 55120.362529603495 49735.85456609468 53380.40077243217 49869.665805020006 51217.159203915864 47429.0058530915 46056.5522041606 50116.407336855584 51401.99688195726 50797.73212749434 1.0850949485551842 0.9790959651754824 1.050842203712082 0.9817301622807681 1.0082568071221925 0.9336835300846135 0.9066655198024566 0.9865874958959047 1.0118955065345498 1.0 15.632476468644287 -6.0157102605166655 1.4286287616058797 0.9658469460210786 1.035433470878023 0.32674921497333065 0.040012680450029016 0.5057180501374334 2.0892771419348217 0.01450840663455787 0.025444909944834518 9.644722565214407e-07 6.0157102605166655 0.0695865248569445 AVTEQGHELSNEER ddPTM_A459_Selumetinib_30min_R1 2 AVTEQGHELSNEER 14 0 P31946-2;P31946;Q4VY20;A0A0J9YWZ2;Q4VY19;A0A0J9YWE8 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ; 283.21 1.0657e-54 96002000.0 6491.7 7086.5 7093.1 7651.1 7675.200000000001 6570.3 6306.1 6370.6 3085.8999999999996 5011.1 False True 6642.9439793506845 6256.8092855755285 6129.895979609358 6314.979013934658 6980.979515166624 6504.2087473550855 5830.425799929767 6201.630993374828 5236.546914781445 5654.3234972474875 1.174843282770159 1.106553116145783 1.0841077597688527 1.1168407709620392 1.234626833531005 1.15030715001031 1.0311447165638834 1.0967945142144357 0.9261137813092202 1.0 12.46513871019476 -7.8006749788643575 1.4120668164029033 0.9747357095476812 1.140196069008737 0.5998799983470333 0.053376424018940063 0.31886832325487424 1.168634308910417 0.04579717415065908 0.01729042287287588 1.5824318705553235e-08 7.8006749788643575 0.16546035946105575 AVTEQGHELSNEER ddPTM_A459_Selumetinib_30min_R2 2 AVTEQGHELSNEER 14 0 P31946-2;P31946;Q4VY20;A0A0J9YWZ2;Q4VY19;A0A0J9YWE8 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ; 236.05 7.222e-15 72179000.0 266710.0 206504.0 278270.0 298740.0 308860.0 218623.0 174799.0 228444.0 196035.0 247993.0 False True 251887.32592472367 222342.19278498544 260366.4111574673 258051.09664475513 270058.24555656686 248736.3337880015 182927.49985764755 229108.7342190598 235247.47767554925 240832.79772680474 1.0459012572301674 0.9232222308740746 1.0811086098531357 1.0714948257898098 1.1213516103521532 1.032817523758381 0.7595622422871006 0.951318659175963 0.9768083080710985 1.0 17.877672352812397 -7.035690561302002 24.986997164465894 0.9147689736834311 1.047961552316003 0.3844641170382903 0.07690318717121418 617.06678210252 432007.32724354195 0.02998341243071561 0.023234969377434727 9.211056339929588e-08 7.035690561302002 0.13319257863257195 AVTGQTTQVS(ph)PPVIAGR ddPTM_A459_Selumetinib_30min_R1 1 AVTGQTTQVSPPVIAGR 17 0 Q6MZP7-3;Q6MZP7 Q6MZP7-3 LIN54 Protein lin-54 homolog 1 AVTGQT(0.002)T(0.008)QVS(0.99)PPVIAGR 99.891 0.0072002 0.0 699.87 619.68 691.86 726.41 761.2 574.08 491.78 461.94 341.34 505.27 True False 716.1756092900412 547.1275775185835 597.9092121149471 599.5561299044942 692.3495944007756 568.3052764229353 454.68463866565037 449.6878506074098 579.2290495127838 570.1263262465801 1.2561700386736652 0.9596602583160673 1.0487311050013692 1.0516197942509775 1.2143792744300212 0.9968058836440098 0.7975155991463528 0.7887512467068911 1.0159661514424907 1.0 9.155137810906233 -7.002651513447833 24.412657265856787 0.8849836754312929 1.0931439070873112 0.4562538012808455 0.10492219781657085 69.51848989573124 640069.1583959627 0.036930032070396336 0.03198658598786869 9.939132643492517e-08 7.002651513447833 0.20816023165601838 AVTGQTTQVS(ph)PPVIAGR ddPTM_A459_Selumetinib_30min_R2 1 AVTGQTTQVSPPVIAGR 17 0 Q6MZP7-3;Q6MZP7 Q6MZP7-3 LIN54 Protein lin-54 homolog 1 AVTGQTTQVS(1)PPVIAGR 197.94 5.5598999999999994e-21 0.0 9169.1 8473.2 12948.0 13217.0 14011.0 8842.2 9547.4 9662.4 6384.5 10980.0 True False 8659.518128815493 9123.067194367835 12114.939776716472 11416.821799403271 12250.812920070759 10060.13278850015 9991.373017814201 9690.515984303569 7661.578397834812 10662.978870533909 0.8121105962936134 0.8555833510632317 1.136168412580739 1.0706972167930044 1.148910925250417 0.9434636334411518 0.9370151755082603 0.9088000737844801 0.7185213898347701 1.0 13.380322913461693 -7.534303009811127 1.928552848593425 0.8573665589832355 1.0055848939910965 0.16347603367401564 0.12085870555869505 0.6032300878930414 4.419769450354732 0.0791930074641133 0.03971279729564302 2.922112891116123e-08 7.534303009811127 0.14821833500786097 AVTHTSPEDVSFAES(ph)R ddPTM_A459_Selumetinib_30min_R2 1 AVTHTSPEDVSFAESR 16 0 A0A0J9YVU1;I3L439;A0A0J9YWI5;A0A0J9YVR1;J3KR97;Q9BTW9;Q9BTW9-4 A0A0J9YVU1 TBCD Tubulin-specific chaperone D 1 AVTHT(0.007)S(0.007)PEDVS(0.005)FAES(0.98)R 79.804 0.024113 106240000.0 8057.6 8298.6 13744.0 17079.0 19385.0 14517.0 8546.9 13376.0 15437.0 13166.0 True False 7609.790849128462 8935.075935795312 12859.726003335742 14752.810737081678 16949.682995901203 16516.58497779473 8944.347785361051 13414.921945484 18524.831345818147 12785.863370623812 0.5951722326872625 0.698824606269774 1.0057768983267592 1.1538376650400495 1.325658072871636 1.2917848798339613 0.6995497704058966 1.0491995383202266 1.4488525967186474 1.0 13.64226196198762 -5.289198729392589 2.339661274053609 1.1356135559244158 0.6028775072708377 0.5026587976048044 0.19395911200699517 0.2781022393255549 2.870634347168787 0.05687366201217588 0.18878450693273655 5.138084834702148e-06 5.289198729392589 -0.5327360486535782 AVTIANS(ph)PSKPSEK ddPTM_A459_Selumetinib_30min_R1 1 AVTIANSPSKPSEK 14 1 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVT(0.001)IANS(0.987)PS(0.011)KPSEK 210.34 2.1215e-05 133570000.0 4369.6 5678.2 3896.3 4350.1 3312.6 3411.7 4388.2 3624.9 2168.4 3385.9 True False 4471.403178238482 5013.393704276435 3367.203860843914 3590.4366964903297 3012.9759148870307 3377.3813955757496 4057.1945410399117 3528.755876665367 3679.616426330111 3820.5132464589133 1.1703671443575947 1.3122304205915674 0.8813485633022855 0.9397786278631981 0.7886311918116348 0.8840124814921436 1.0619501306010048 0.9236339855478933 0.9631209706550831 1.0 11.899550747106973 -5.2643513094117536 24.999975279952913 0.9259083610912581 1.2412987956800376 0.726393566657813 0.07630710725416091 117.57205057221866 1009408.251782961 0.020405206917318362 0.04573926720004442 5.440623719574457e-06 5.2643513094117536 0.3153904345887796 AVTIANS(ph)PSKPSEK ddPTM_A459_Selumetinib_30min_R2 2 AVTIANSPSKPSEK 14 1 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVT(0.007)IANS(0.941)PS(0.021)KPS(0.032)EK;AVTIANS(0.68)PS(0.32)KPSEK 101.78 0.004425899999999999 772450000.0 496480.0 379090.0 398040.0 391180.0 351334.0 313447.0 426630.0 418290.0 327329.0 345620.0 True False 468887.62916691025 408164.98403352883 372430.5397531832 337900.6091768616 307196.28195418924 356621.47906143346 446469.14035130676 419507.1546483629 392803.9463364196 335641.0525713957 1.3969912964301978 1.2160758670803722 1.1096096168807057 1.0067320626846898 0.9152524090861744 1.0625085231061684 1.3301982487864363 1.2498684276981513 1.170309601066647 1.0 18.356559658387987 -4.852950718630316 2.379246187799791 1.111178083797951 1.4392045089072978 0.3734910764732413 0.11618588258471652 0.602826931876534 4.779188545492039 0.035179219324062684 0.39011316602626517 1.4029728972438725e-05 4.852950718630316 0.32802642510934676 AVTIANS(ph)PSKPSEKDSVVSLESQK ddPTM_A459_Selumetinib_30min_R1 1 AVTIANSPSKPSEKDSVVSLESQK 24 2 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVT(0.011)IANS(0.785)PS(0.168)KPS(0.034)EKDS(0.001)VVSLESQK 63.165 0.0017168 214520000.0 2944.1 2997.5 6067.6 5585.2 3633.4 3792.2 3365.7 3056.7 1998.9 2300.8 True False 3012.691801778632 2646.5513065000578 5243.653246941079 4609.849667188754 3304.7596115288698 3754.05391104211 3111.8225392593836 2975.626386439082 3391.9873061203016 2596.1300916898513 1.1604548675824007 1.0194216826697566 2.0197960278361564 1.7756620448045997 1.2729560903389718 1.446019181804003 1.1986389084353866 1.146177688076568 1.306555213460978 1.0 11.342146963042804 -7.197168392474518 1.6917904727998263 1.1589150901882954 1.4789552726226576 0.19906985144254608 0.27968196211490604 0.7065459269767858 3.9663426099760595 0.16180704589324224 0.10448360672176488 6.35084637657769e-08 7.197168392474518 0.32004018243436216 AVTIANS(ph)PSKPSEKDSVVSLESQK ddPTM_A459_Selumetinib_30min_R2 2 AVTIANSPSKPSEKDSVVSLESQK 24 2 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVT(0.014)IANS(0.755)PS(0.212)KPS(0.018)EKDS(0.001)VVSLESQK;AVT(0.023)IANS(0.639)PS(0.268)KPS(0.066)EKDS(0.002)VVSLESQK 58.952 0.0040292 149563000.0 265550.0 302250.0 273760.0 274120.0 237380.0 143735.0 145233.0 158826.0 103603.0 268310.0 True False 250791.79408087564 325431.603113071 256146.5796473517 236784.38311662452 207558.20219587447 163533.1915535805 151986.62227372994 159288.15736494036 124326.49490968417 260563.19314689934 0.9624989280027942 1.2489546170460093 0.9830497414227739 0.9087407175852773 0.7965752940357086 0.6276143210349144 0.5833004287295616 0.6113225565022051 0.4771452690925224 1.0 17.991273779314618 -6.1603365252413065 1.291281274592641 0.6287055594091538 1.102085010720779 0.5895931399440281 0.14690575572926218 0.27192105268241795 0.9203979282522732 0.05356381052101635 0.08442836813053138 6.91295093963498e-07 6.1603365252413065 0.47337945131162507 AVTIANSPS(ph)KPSEK ddPTM_A459_Selumetinib_30min_R1 1 AVTIANSPSKPSEK 14 1 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVT(0.064)IANS(0.253)PS(0.682)KPS(0.001)EK 184.87 0.00037347 118540000.0 2174.0 3090.5 2294.6 2383.2 1891.4 2274.8 2145.8 2070.4 745.59 1693.1 True False 2224.6499701323814 2728.6628232655275 1983.0059233355848 1967.018858204583 1720.3232039537909 2251.9175773531447 1983.9405784065093 2015.4862663929996 1265.211774260961 1910.4258771905795 1.1644785577359804 1.428300807607477 1.0379915530937738 1.0296232278308686 0.9004919921225374 1.1787516093870931 1.03848079221165 1.0549931774149328 0.6622668742958754 1.0 10.899678568170616 -5.383715492747812 5.702603477348155 0.9935482984526744 1.294038075736958 0.44025956355536944 0.13970703731837109 0.19799182394749842 8.3146905166554 0.03614195068861825 0.0767792308011832 4.133181789508132e-06 5.383715492747812 0.3004897772842836 AVTIANSPS(ph)KPSEKDSVVSLESQK ddPTM_A459_Selumetinib_30min_R1 1 AVTIANSPSKPSEKDSVVSLESQK 24 2 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVTIANS(0.1)PS(0.747)KPS(0.15)EKDS(0.002)VVSLESQK 82.26700000000002 0.00021149 140280000.0 1005.3 1372.3 2070.0 2131.7 1223.9 1363.3 1374.2 1191.7 751.87 1052.0 True False 1028.7215340267176 1211.6304780350379 1788.905369696096 1759.4386119648818 1113.1984610970958 1349.5864397773614 1270.5429876252329 1160.092244812856 1275.8684755879078 1187.0344473477587 0.8666315761309485 1.0207205702768232 1.5070374526140524 1.482213608792963 0.9377979414029325 1.1369395747467983 1.0703505618257843 0.9773029311869585 1.0748369421280357 1.0 10.213146086783171 -6.30312204771823 24.999237472699832 1.0388138548752295 1.2255410509025075 0.19451687824411257 0.18528459124099297 921.451016920293 552638.991537087 0.0630707471420053 0.07151594947362869 4.975972279394956e-07 6.30312204771823 0.18672719602727805 AVTIANSPS(ph)KPSEKDSVVSLESQK ddPTM_A459_Selumetinib_30min_R2 1 AVTIANSPSKPSEKDSVVSLESQK 24 2 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 AVTIANS(0.007)PS(0.945)KPS(0.036)EKDS(0.012)VVSLESQK 109.83 4.5227e-07 15929000.0 94235.0 102170.0 80001.0 93083.0 65726.0 53333.0 51534.0 46771.0 30134.0 79243.0 True False 88997.7959525938 110006.1104716708 74853.82275850282 80404.93482286857 57468.912282104815 60679.13664122937 53930.433112683735 46907.09586664413 36161.64201430876 76955.04869195992 1.1564906717015966 1.4294852948766177 0.9726954115529443 1.0448298869216242 0.7467854709850769 0.7885010492829301 0.7008043530523846 0.6095389017867631 0.4699060377319577 1.0 16.231728358265656 -5.918231513613853 0.9441753760715272 0.669223886493556 1.312428713666007 0.663522236974478 0.15636879840636062 0.35170271720190177 0.6199590205806658 0.06423168555271194 0.15931998776630532 1.2071701455380498e-06 5.918231513613853 0.6432048271724511 AVTSGLPGDTALLLPPS(ph)PRPSPR ddPTM_A459_Selumetinib_30min_R1 1 AVTSGLPGDTALLLPPSPRPSPR 23 1 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;Q6W2J9-3 H7BYY2 BCOR BCL-6 corepressor 1 AVTSGLPGDTALLLPPS(0.978)PRPS(0.022)PR 96.312 3.9919e-05 9598700.0 1371.4 1685.8 1965.9 1980.1 1641.6 1369.5 1486.1 1455.5 694.91 947.36 True False 1403.3509517201246 1488.4257522928428 1698.9415779157262 1634.3127060804354 1493.11756984802 1355.7240734065101 1374.0022805340263 1416.8954118696909 1179.2115157817082 1068.962884067845 1.3128154144882889 1.3924017142941096 1.5893363588551852 1.5288769427252713 1.3967908447542083 1.2682611282511704 1.2853601383290134 1.3254860697106892 1.103136070818775 1.0 10.061996046138768 -8.044412657586655 0.5978406516367598 0.9976773409547325 1.456565356537459 0.7306478962091505 0.08695211520671141 0.42744013605312864 0.34575106474977296 0.09500921021631174 0.048304149937126346 9.027912525779772e-09 8.044412657586655 0.4588880155827265 AVTSGLPGDTALLLPPS(ph)PRPSPR ddPTM_A459_Selumetinib_30min_R2 2 AVTSGLPGDTALLLPPSPRPSPR 23 1 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;Q6W2J9-3 H7BYY2 BCOR BCL-6 corepressor 1 AVTSGLPGDTALLLPPS(0.986)PRPS(0.014)PR;AVTSGLPGDTALLLPPS(0.954)PRPS(0.046)PR 100.9 2.448e-05 12244200.0 46616.0 50621.0 43732.0 56013.0 58293.0 39799.0 36249.0 39665.0 31981.0 47249.0 True False 44025.26933863338 54503.467927830534 40918.330731801434 48383.93277218547 50969.712193967986 45280.95099064906 37934.650326030845 39780.41858310578 38378.093623800625 45884.798602354924 0.9594739582527859 1.1878327809644844 0.8917622388714462 1.0544654056671023 1.1108191328391728 0.9868399201892787 0.826736772994879 0.8669629113521737 0.8364010476844713 1.0 15.485728654900807 -7.084049354935789 4.746721955019539 0.8728374565800274 1.0423225398330336 0.4231798386450585 0.08685268767120541 0.20018291537792535 7.874291756512711 0.03236653580847053 0.025142549241916605 8.240444620326398e-08 7.084049354935789 0.16948508325300615 AVTTVTQSTPVPGPSVPPPEELQVS(ph)PGPR ddPTM_A459_Selumetinib_30min_R1 2 AVTTVTQSTPVPGPSVPPPEELQVSPGPR 29 0 P51610;P51610-2;H7C1C4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 AVTTVTQSTPVPGPSVPPPEELQVS(1)PGPR;AVTTVTQSTPVPGPSVPPPEELQVS(1)PGPR 195.47 1.0857000000000002e-35 108114000.0 2470.36 2817.4 2980.6 3224.6000000000004 2985.2 2382.96 2614.34 2276.85 1417.37 2419.67 True False 2527.9145815162055 2487.5374982262733 2575.850891263855 2661.484143238712 2715.1891870798668 2358.9895859545663 2417.1382289827898 2216.4605417488897 2405.17336939103 2730.2582140817044 0.9258884630318546 0.9110997214096588 0.9434458902013475 0.9748104151877357 0.9944807319234068 0.8640170273228129 0.8853148821294804 0.8118135238334497 0.8809325641750653 1.0 11.41482168509618 -6.7786876479636 24.999850258736757 0.8764601333477124 0.9488073208048603 0.26354867391359604 0.04942937815484292 284.59456982706206 412492.14763315587 0.01714998341128173 0.015160952127668137 1.6646094355864685e-07 6.7786876479636 0.07234718745714785 AVTTVTQSTPVPGPSVPPPEELQVS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 4 AVTTVTQSTPVPGPSVPPPEELQVSPGPR 29 0 P51610;P51610-2;H7C1C4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 AVTTVTQSTPVPGPSVPPPEELQVS(1)PGPR;AVTTVTQSTPVPGPSVPPPEELQVS(1)PGPR;AVTTVTQSTPVPGPSVPPPEELQVS(1)PGPR;AVTTVTQSTPVPGPSVPPPEELQVS(1)PGPR 200.14 6.1448e-42 63842000.0 128088.0 132337.0 151366.0 157147.0 167533.0 113876.0 122999.0 128561.0 109305.0 148979.0 True False 120969.38173689027 142486.82236947704 141627.27635483985 135743.30750630438 146486.00677597718 129561.38533659518 128718.69721789482 128935.09122558088 131169.05423687588 144677.58917607192 0.8361307540843186 0.9848575939157465 0.9789164801639053 0.9382469550353472 1.0124996387498855 0.8955180002268327 0.889693406912143 0.8911891050981469 0.9066300799168264 1.0 17.142481937505096 AVVIVDDR ddPTM_A459_Selumetinib_30min_R2 2 AVVIVDDR 8 0 Q15233-2;Q15233;H7C367;C9IZL7;P23246;P23246-2 Q15233-2;P23246 NONO;SFPQ Non-POU domain-containing octamer-binding protein;Splicing factor, proline- and glutamine-rich 0 ; 139.28 0.033446 21519000.0 203818.0 196618.0 210023.0 202029.0 227632.0 174198.0 167168.0 167329.0 160469.0 194875.0 False True 192490.61150809965 211697.9683734853 196510.34883575302 174512.3016805361 199034.83310410017 198192.19328799943 174941.64323710772 167815.8996871928 192567.28387847968 189248.452403943 1.0171317601965717 1.118624568308885 1.0383722896518583 0.9221333092227714 1.0517118136283015 1.0472592550715627 0.9244019753657061 0.886749125583319 1.0175369015301259 1.0 17.529921976929003 -5.839789622020709 0.6276757193730368 0.9609726214207893 1.0814709284383612 0.21382513499406863 0.05987427189883981 1.794410144503029 1.2214350589302925 0.03838798210181679 0.1325418873573016 1.4461401304673006e-06 5.839789622020709 0.12049830701757192 AVVLPGGTAT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 AVVLPGGTATSPK 13 0 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 AVVLPGGT(0.003)AT(0.937)S(0.06)PK 145.81 0.0014434 29157000.0 4079.1 4799.8 4949.7 5163.2 3641.6 4026.7 4426.3 4142.1 2710.3 3863.5 True False 4174.135093453082 4237.8371846335185 4277.557926755926 4261.5440452676685 3312.2179229767 3986.1950539510713 4092.420627365426 4032.238052563001 4599.181147520063 4359.417858676869 0.9574982781577119 0.9721108005736684 0.9812222790806778 0.9775488800151618 0.7597844552533888 0.9143870083518272 0.938753925416895 0.9249487393224629 1.0549989233920247 1.0 12.089919780106273 -10.618977090291244 5.559414381150076 1.000000579402531 0.9386034104913928 0.0530428721016889 0.0714912021009238 5.352956125122797e-07 8.705923413740227e-08 0.07217838590868626 0.01750566481891152 2.4044896372260935e-11 10.618977090291244 -0.06139716891113822 AVVLPGGTATS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AVVLPGGTATSPK 13 0 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 AVVLPGGTAT(0.051)S(0.949)PK 139.19 0.00094787 19539000.0 3770.8 4322.4 4545.5 4642.3 3580.3 3437.2 3383.6 3810.7 2520.3 3752.8 True False 3858.652303300454 3816.331398570755 3928.2460666442526 3831.609451763652 3256.4624971533053 3402.6248887278994 3128.3723278480115 3709.627857101911 4276.765024571008 4234.508435367558 0.9112397252706194 0.9012454354077806 0.9276746348725311 0.9048534228344418 0.7690296398879749 0.8035466077498908 0.738780516226901 0.8760468691284855 1.0099791014348947 1.0 12.047978788099488 -8.218010680280543 4.794715495836018 1.0066238418824676 0.8503523588393694 0.49972277989102776 0.060659528844324836 0.1778120361236893 9.514707292407154 0.05295284431596168 0.017782576422148342 6.053259882399483e-09 8.218010680280543 -0.15627148304309812 AVVLPGGTATS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 AVVLPGGTATSPK 13 0 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 AVVLPGGTAT(0.038)S(0.962)PK;AVVLPGGTAT(0.271)S(0.729)PK 173.06 0.00015947 25982000.0 226310.0 192013.0 190008.0 200274.0 184834.0 138567.0 184274.0 168460.0 118583.0 164697.0 True False 213732.59619070968 206739.77968089384 177783.0921450686 172996.33570807963 161613.50048307478 157653.3464640133 192843.10613200383 168950.1907099456 142302.9134858554 159941.7696758035 1.3363150640632422 1.292594049071411 1.1115488624730667 1.0816207427161604 1.010452121485587 0.985692147733336 1.2057082182027261 1.0563231296765183 0.8897170124745933 1.0 17.287187230232682 -5.295038663969255 1.6546646599842143 1.036540442167102 1.3555707075998684 0.6885903083892967 0.07522263904566626 0.27990542397617696 1.314788027578488 0.023013281459685522 0.10264328022778968 5.069455743818432e-06 5.295038663969255 0.31903026543276636 AVVS(ph)PPKFVFGSESVK ddPTM_A459_Selumetinib_30min_R1 1 AVVSPPKFVFGSESVK 16 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 AVVS(1)PPKFVFGSESVK 108.49 0.014884 21817000.0 1588.2 2056.7 2229.4 2319.1 1582.7 1911.9 1718.7 1716.9 872.71 1440.9 True False 1625.2019699007583 1815.9006078661098 1926.6597252176223 1914.11271989856 1439.5450644483794 1892.6680218663062 1589.057075266692 1671.3622347228252 1480.9251297835044 1625.8535505545494 0.9995992377950838 1.1168906370729017 1.1850143111355098 1.1772971306337465 0.8854088143162565 1.1641073214870743 0.9773679029852923 1.0279906416864875 0.9108601013162517 1.0 10.666981596562076 -7.126836475009573 0.8089309974016787 0.9666752704085761 1.1080290374236 0.2349094529747603 0.09126668566339526 0.9468045205676598 1.2519047646047183 0.07093440639986405 0.04775939890114796 7.467298718348351e-08 7.126836475009573 0.14135376701502378 AVVVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AVVVSPK 7 0 G3V5E1;O75909-1;O75909 G3V5E1 CCNK Cyclin-K 1 AVVVS(1)PK 84.615 0.037299 69732000.0 12088.0 14973.0 10329.0 9742.5 8807.1 10214.0 11662.0 12204.0 7449.1 13339.0 True False 12369.626880846468 13219.95419924115 8926.37853313574 8041.155264374855 8010.499360019795 10111.256433569983 10782.325950869938 11880.31027582117 12640.578639261963 15051.19058286288 0.8218371040315169 0.8783327887890308 0.5930679359876829 0.5342537668435628 0.5322169908034027 0.6717911369139493 0.7163769464952875 0.7893269446304109 0.8398391190165638 1.0 13.877589991455048 -8.331269611270812 1.1226568870344147 0.9919046940706227 0.6675565929035284 0.4834399953660117 0.1061389205450756 0.45928467047285626 1.2100545897012627 0.11492891506805618 0.037638540712391345 4.6636976672668634e-09 8.331269611270812 -0.3243481011670942 AVVVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 AVVVSPK 7 0 G3V5E1;O75909-1;O75909 G3V5E1 CCNK Cyclin-K 1 AVVVS(1)PK 79.986 0.045736 186180000.0 596920.0 448700.0 500420.0 441450.0 456040.0 313750.0 525940.0 500670.0 332280.0 355780.0 True False 563745.5760600868 483113.8472021022 468223.5220161004 381323.7484562747 398748.1781506726 356966.2145610729 550397.2521303394 502126.86680961977 398745.2846789185 345507.70697254606 1.6316439971768326 1.3982722742578078 1.3551753334790455 1.1036620624111708 1.1540934401858567 1.0331642604702804 1.593010057440119 1.4533014942254778 1.1540850656353163 1.0 18.39835836648902 -4.8595337576195465 1.5826539493418559 1.2415410129471194 1.731124548590241 0.33783896760707277 0.17694675486478037 1.1782100072593347 3.2029003136954195 0.05326507628924149 0.8613988266869965 1.3818669894935886e-05 4.8595337576195465 0.4895835356431215 AVVVS(ph)PKEENK ddPTM_A459_Selumetinib_30min_R1 3 AVVVSPKEENK 11 1 G3V5E1;O75909-1;O75909 G3V5E1 CCNK Cyclin-K 1 AVVVS(1)PKEENK;AVVVS(1)PKEENK;AVVVS(1)PKEENK 153.38 0.002666 437243000.0 17723.3 19943.8 30604.6 32540.3 17333.4 21876.7 17706.0 17576.0 13222.1 15993.9 True False 18136.218406461478 17608.77062437893 26448.663419034347 26857.747462082327 15765.597030460323 21656.640260454344 16370.422164817612 17109.82738510594 22436.937996024408 18046.87285877882 1.0049507495498975 0.975724202313157 1.4655538178831082 1.4882216809666 0.873591627415451 1.2000217672015996 0.9071057513908451 0.948077127765819 1.243259049454103 1.0 14.139461249792971 -6.280525375212024 24.96488058949115 1.0285685461405778 1.231759287231711 0.2192063299663628 0.18946854388045054 1373.6832871119345 1796801.9002740833 0.06250650213327266 0.07098713222160222 5.241729734286082e-07 6.280525375212024 0.2031907410911331 AVVVS(ph)PKEENK ddPTM_A459_Selumetinib_30min_R2 4 AVVVSPKEENK 11 1 G3V5E1;O75909-1;O75909 G3V5E1 CCNK Cyclin-K 1 AVVVS(1)PKEENK;AVVVS(1)PKEENK;AVVVS(1)PKEENK;AVVVS(1)PKEENK 141.37 0.0047919 228844800.0 343019.0 359880.0 345412.0 300967.0 258622.0 160820.0 186630.0 170586.0 101341.59999999999 268192.0 True False 323955.37719385326 387481.63880341564 323188.56797615084 259974.7754029659 226131.5922499851 182971.49522139208 195308.6648003292 171082.3770179676 121612.75172088927 260448.60011350038 1.243836123721446 1.4877470588613484 1.240891937354661 0.998180736197745 0.8682388469411609 0.7025243949925447 0.7498933175882536 0.6568757787272113 0.46693570888033914 1.0 17.990639157197386 -6.008020996104993 1.2410207204348782 0.691754259045054 1.3877110365982017 0.7853043515861551 0.1383458982863116 0.19213247685267693 0.6016008030123843 0.050158645200410086 0.0946977117481152 9.81700481250408e-07 6.008020996104993 0.6959567775531477 AWGPGLEGGVVGK ddPTM_A459_Selumetinib_30min_R2 2 AWGPGLEGGVVGK 13 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 166.97 0.004407199999999999 5660500.0 29872.0 30724.0 33911.0 35600.0 36799.0 30349.0 30525.0 29184.0 28358.0 33258.0 False True 28211.833827090617 33080.43200676925 31729.20317950515 30751.21858657459 32175.98063276596 34529.29926920798 31944.47298414003 29268.920608328706 34030.39238872261 32297.755125338517 0.8734920962032319 1.0242331666208189 0.9823965491215418 0.952116283848142 0.996229629827213 1.0690928559960116 0.9890617121893612 0.9062215158528587 1.0536457489587192 1.0 14.979146272577264 -4.752538872928675 24.81132486439185 0.9941909669674047 0.8734918408591681 0.4086977248490573 0.044452137118795185 332.5077334481294 926833.3947583388 0.011134778662051216 0.130489965774087 1.7679139678089568e-05 4.752538872928675 -0.12069912610823663 AWGPGLHGGIVGR ddPTM_A459_Selumetinib_30min_R2 2 AWGPGLHGGIVGR 13 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 ; 131.42 0.0021442 2620000.0 40926.0 37570.0 41509.0 37485.0 45393.0 27887.0 31516.0 34625.0 31644.0 41018.0 False True 38651.49675975864 40451.498193409716 38838.35613158205 32379.478334768224 39690.325521431165 31728.181117018776 32981.55644776925 34725.753017522686 37973.68420723389 39833.70376243715 0.9703214391077205 1.015509339394022 0.9750124257389867 0.8128663738595606 0.9964005797236161 0.796515968141988 0.8279811650070709 0.8717681193951334 0.953305382640385 1.0 15.281702008166354 -5.607717931615102 8.159465184781935 0.8863611191548423 0.9934762295915739 0.27290420400449034 0.0690148733920318 0.28135826806121783 23.622559526726743 0.018225422019339334 0.03165647719121986 2.4676415166300288e-06 5.607717931615102 0.10711511043673161 AWLDEDSNLSPS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 1 AWLDEDSNLSPSPLR 15 0 Q9C086;B8ZZ93;B8ZZH7;F8WCL7;J3KQ70 Q9C086 INO80B;INO80B-WBP1 INO80 complex subunit B 1 AWLDEDS(0.001)NLS(0.024)PS(0.975)PLR 102.63 0.0061729 14695000.0 1170.0 1383.3 1517.1 1457.0 1079.5 1144.4 1417.5 1269.6 700.35 1115.4 True False 1197.2587235763049 1221.3425929212774 1311.0861528337907 1202.5623012773065 981.8594156012041 1132.888375032063 1310.576833764203 1235.9260837579932 1188.442798459829 1258.572454916056 0.9512831135782004 0.9704189759998667 1.0417248110846644 0.9554970765330429 0.780137378476706 0.900137588906333 1.0413201311096671 0.9820063031972417 0.9442784114793737 1.0 10.297572558244145 -9.854965781753974 11.35501104502144 1.0000036628287456 0.9521074598942003 0.0403581236183056 0.07040416340407868 0.0 0.0 0.07482177834783273 0.018146946777921582 1.3964783858444538e-10 9.854965781753974 -0.04789620293454533 AWLDEDSNLSPS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 3 AWLDEDSNLSPSPLR 15 0 Q9C086;B8ZZ93;B8ZZH7;F8WCL7;J3KQ70 Q9C086 INO80B;INO80B-WBP1 INO80 complex subunit B 1 AWLDEDSNLS(0.013)PS(0.987)PLR;AWLDEDSNLS(0.019)PS(0.981)PLR;AWLDEDSNLS(0.023)PS(0.977)PLR 123.76 0.0016038 0.0 34057.7 22614.100000000002 40544.9 39712.0 34676.0 33612.7 41341.0 43426.0 34554.0 33893.6 True False 32164.9093777753 24348.5287542078 37936.28527594933 34303.157092978945 30319.690872626765 38242.54431928916 43263.43841563742 43552.362470438704 41465.76551942737 32915.003701851376 0.9772111730300707 0.7397395113413967 1.15255297005528 1.042173879234578 0.9211510698059368 1.1618575123276722 1.3143987103122816 1.3231765934144193 1.2597831036274512 1.0 15.006457739561426 -6.906459700590677 4.214943922107835 1.2502644280951047 0.969126457799294 0.47323879869946406 0.12920642185462283 0.1828558786760455 5.979945354491899 0.04732373835390113 0.041321481784114565 1.240338714305098e-07 6.906459700590677 -0.2811379702958108 AY(ph)Y(ph)KS(ph)S(ph)HLK ddPTM_A459_Selumetinib_30min_R2 1 AYYKSSHLK 9 1 Q9BXK1;Q8TD94 Q9BXK1 KLF16;KLF14 Krueppel-like factor 16;Krueppel-like factor 14 4 AY(1)Y(1)KS(1)S(1)HLK 49.35 0.038967 4131900.0 10788.0 7033.6 9419.9 10666.0 11269.0 8278.0 10843.0 11024.0 9178.5 8829.9 True False 10188.446147785671 7573.054503411408 8813.83388961164 9213.272400123731 9853.287473861785 9418.219359797811 11347.220984996891 11056.078014878556 11014.456468717482 8574.957844164608 1.1881628263302852 0.8831593858580878 1.0278574017258395 1.0744393812260553 1.1490770745382848 1.0983400188033643 1.323297582473697 1.2893448825993226 1.2844910341119626 1.0 13.065913863450259 -6.619998438573385 1.3018531379785974 1.2402410025324688 1.0248012273055496 0.2970424290453926 0.11332364001867833 0.4437657550756236 1.5740838972073645 0.049716491596848704 0.051017466960531166 2.398841543601319e-07 6.619998438573385 -0.21543977522691926 AYEFAER ddPTM_A459_Selumetinib_30min_R2 1 AYEFAER 7 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 133.81 0.042994 13920000.0 60523.0 49723.0 61793.0 72508.0 76978.0 52453.0 45339.0 59464.0 53665.0 69522.0 False True 57159.373952765294 53536.594215355675 57817.30565513138 62632.28531672334 67307.33544794854 59677.92462907399 47447.353337524146 59637.03039520488 64399.49952538255 67514.71922015098 0.8466209237482107 0.7929618138643865 0.8563659350578291 0.9276834154118738 0.996928317638022 0.8839246510746362 0.7027705052406207 0.8833189426551764 0.9538586588117124 1.0 16.042914445134215 -14.522878717347341 0.230874826724513 1.7140109657204743 0.8553676976640414 0.21617068584419252 0.07732872653879153 294.42585303301144 2.938732286140988 98.01454446804752 0.14686594553118718 3.0000001929543103e-15 14.522878717347341 -0.8586432680564329 AYGELPEHAK ddPTM_A459_Selumetinib_30min_R1 1 AYGELPEHAK 10 0 X6RAC9;A6NJH9;P47813;O14602 X6RAC9 EIF1AX;EIF1AY Eukaryotic translation initiation factor 1A, X-chromosomal;Eukaryotic translation initiation factor 1A, Y-chromosomal 0 103.31 0.02017 4771600.0 8659.6 9749.0 10961.0 11430.0 10113.0 8504.9 8673.2 8925.4 4900.5 7341.7 False True 8861.351831351598 8607.582547812859 9472.556404463236 9433.96506767304 9198.280935595163 8419.348427831348 8018.973541166625 8688.669398214874 8315.790581641166 8284.078709213916 1.0696846496032941 1.0390512753384546 1.1434652828596912 1.1388067881561976 1.1103565355269296 1.0163288789696046 0.9679982316256327 1.04883955153045 1.0038280505944468 1.0 13.016125545711233 -6.79000156752168 6.769318595047319 1.0074795830848031 1.1014805204265383 0.6515680516142711 0.03396901258169816 0.1232187430242122 18.62409451746233 0.012960501705287533 0.011674881920639375 1.6218042436858905e-07 6.79000156752168 0.0940009373417352 AYGPGIEPTGNMVK ddPTM_A459_Selumetinib_30min_R2 1 AYGPGIEPTGNMVK 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 176.95 0.00096752 2066200.0 13248.0 11946.0 13829.0 16792.0 15363.0 10648.0 11204.0 11652.0 7586.1 13197.0 False True 12511.729195945909 12862.219787555829 12939.257195876751 14504.90063218429 13432.962593037404 12114.665347079852 11725.008200304816 11685.905390907552 9103.531973343985 12815.968320076143 0.9762609335063941 1.0036088937117014 1.0096199423033434 1.1317834337544705 1.0481426184547245 0.9452789710865855 0.9148749362884782 0.9118238356286857 0.7103272843678423 1.0 13.645654866200413 -7.1680114712296366 1.7221902421410629 0.8645230026768703 1.0351934043697968 0.44825274245055624 0.07795824183878045 0.3312427922135143 1.932181330079294 0.040176183182981814 0.02667014901415155 6.791856927209446e-08 7.1680114712296366 0.17067040169292647 AYGVPVKPMT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 AYGVPVKPMTPK 12 1 H3BT74;F8W872;Q15131-4;Q15131-3;Q15131-2;Q15131 H3BT74 CDK10 Cyclin-dependent kinase 10 1 AYGVPVKPMT(1)PK 141.38 0.010327 8763100.0 1157.3 1289.7 1671.4 1624.1 1318.4 1247.0 1127.0 1191.7 792.46 1039.5 True False 1184.262838286203 1138.7013244347359 1444.4330603430212 1340.481423132789 1199.150952782426 1234.45631218541 1041.9894826470947 1160.092244812856 1344.7467410116026 1172.9299505874483 1.009662032837578 0.970817842842559 1.2314742748444558 1.1428486607076787 1.0223551305701122 1.0524552737076474 0.8883646309186891 0.989055010686561 1.1464851249966819 1.0 10.195901140349239 -6.4185270900510565 6.498229462394213 1.0098689373661511 1.0903733484407518 0.13523582675962298 0.08902788093509578 0.5128236751460467 27.435521309042272 0.02970952522395884 0.03363500958089909 3.814809978407102e-07 6.4185270900510565 0.08050441107460071 AYHEQLSVAEITNACFEPANQMVK ddPTM_A459_Selumetinib_30min_R1 1 AYHEQLSVAEITNACFEPANQMVK 24 0 P68363;P68363-2;C9JDS9;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 183.27 1.6471e-20 10528000.0 1405.6 1289.7 1642.8 1388.9 1581.3 1370.3 1471.0 1419.1 855.17 1167.8 False True 1438.3477451785084 1138.7013244347359 1419.716783254466 1146.3546878819843 1438.27169420119 1356.5160261328515 1360.0412856911048 1381.4608581135544 1451.1610308544184 1317.6985053352787 1.0915605803260218 0.8641592290073985 1.0774215630556776 0.8699673584211153 1.0915028653198877 1.0294585754179755 1.0321338911627984 1.0483891819867033 1.101284569253709 1.0 10.363804598395989 -6.305138729802201 24.99819882580569 1.050914441286997 0.9750645266743856 0.1957388270975602 0.0741552467978488 709.2240076026455 405709.45181258826 0.021119423534254153 0.023947292223428607 4.95291950870937e-07 6.305138729802201 -0.07584991461261148 AYILVT(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 AYILVTPLK 9 0 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 AYILVT(1)PLK 117.52 0.017553 29843000.0 4336.3 5496.7 6171.7 6183.4 5049.8 4638.6 5048.6 4498.0 2163.8 4347.0 True False 4437.327353029002 4853.1438086534945 5333.617038721446 5103.585266793478 4593.046481614603 4591.9398955118195 4667.78003734882 4378.698428436875 3671.8105623008205 4904.979793365693 0.9046576214301185 0.9894319677356653 1.0873881776099288 1.0404905793284638 0.9364047712952865 0.9361791666752062 0.9516410329890245 0.8927046823636974 0.7485883157494727 1.0 12.260031477768955 -7.116733335719969 1.1472090008958855 0.8741143162143507 1.0039159076245125 0.27926971316618343 0.07468284615530732 0.601897061143845 1.5880746158939503 0.048064586067141944 0.03105387775425888 7.643049359028105e-08 7.116733335719969 0.1298015914101619 AYILVT(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 AYILVTPLK 9 0 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 AYILVT(1)PLK 103.08 0.036379 16404000.0 74232.0 64834.0 73016.0 66970.0 68949.0 58616.0 60832.0 57458.0 46312.0 64042.0 True False 70106.48261424038 69806.55932583248 68318.23005380992 57848.570470306244 60287.01020811925 66689.82193693024 63660.808536321216 57625.19326731607 55575.6940653968 62192.94105890099 1.1272417965866048 1.1224193314755908 1.098488492272907 0.9301468862120489 0.9693545470220376 1.0723053259978554 1.0236018341057396 0.9265552052401099 0.8936013174350895 1.0 15.924463222329196 -5.666986730348775 5.868070091086127 0.976862529819664 1.120672012539792 0.6430057000992735 0.048729412074060424 0.14529094525313663 7.3647298444069484 0.014791164570727435 0.0258324327690477 2.1528475129011596e-06 5.666986730348775 0.14380948272012795 AYLGYQAVPSGSSGSLS(ph)TSSSSSPPGTPSPADAK ddPTM_A459_Selumetinib_30min_R2 1 AYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAK 34 0 P17676-3;P17676-2;P17676 P17676-3 CEBPB CCAAT/enhancer-binding protein beta 1 AYLGYQAVPSGSS(0.001)GS(0.011)LS(0.141)T(0.141)S(0.141)S(0.141)S(0.141)S(0.141)S(0.141)PPGT(0.001)PSPADAK 84.741 1.4637e-08 16708000.0 160030.0 151780.0 173430.0 193240.0 183320.0 134230.0 144160.0 155810.0 129450.0 171040.0 True False 151136.17325084732 163421.0379503784 162271.70261630643 166920.3786424063 160289.7026984065 152718.9640813794 150863.72564762083 156263.38130426593 155343.6171352047 166101.63078471043 0.9099018025099326 0.9838617307869395 0.9769422602878108 1.0049291981892523 0.9650098071954697 0.9194308530259 0.9082615561021196 0.9407696996473432 0.9352323417977182 1.0 17.341706712176986 -6.63843816727668 6.3916451153459874 0.9351694510248307 0.9722287929067137 0.13995859602022065 0.032133740434706244 0.32340145795792413 16.88212125503565 0.010501160476801828 0.010478089040170904 2.2991210235644353e-07 6.63843816727668 0.03705934188188298 AYLGYQAVPSGSSGSLSTS(ph)SSSSPPGTPSPADAK ddPTM_A459_Selumetinib_30min_R1 1 AYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAK 34 0 P17676-3;P17676-2;P17676 P17676-3 CEBPB CCAAT/enhancer-binding protein beta 1 AYLGYQAVPSGSSGSLST(0.004)S(0.294)S(0.294)S(0.294)S(0.057)S(0.057)PPGTPSPADAK 139.75 5.1841e-26 47411000.0 6736.2 7484.6 8865.6 9463.9 7968.6 6690.2 7913.8 7305.8 3665.0 5802.4 True False 6893.140353636499 6608.299552503857 7661.700215254928 7811.207524405152 7247.8415369705945 6622.90266221558 7316.855694563067 7112.026451417099 6219.237318990896 6547.194560162202 1.0528387831299955 1.009333003896579 1.170226445060022 1.1930617690719176 1.1070148397714692 1.0115634416172752 1.1175558672235024 1.086270827308499 0.9499087375275462 1.0 12.67666113617299 -8.231689040958464 8.815338620581109 0.9749924739820551 1.095165612464967 0.40248447822034417 0.05774052231890318 0.3277465553806834 94.16047865237675 0.04365545317910976 0.016002118126385766 5.865579953816883e-09 8.231689040958464 0.12017313848291178 AYLGYQAVPSGSSGSLSTS(ph)SSSSPPGTPSPADAK ddPTM_A459_Selumetinib_30min_R2 1 AYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAK 34 0 P17676-3;P17676-2;P17676 P17676-3 CEBPB CCAAT/enhancer-binding protein beta 1 AYLGYQAVPSGSSGSLS(0.009)T(0.097)S(0.256)S(0.256)S(0.256)S(0.063)S(0.063)PPGT(0.001)PSPADAK 112.75 8.8526e-15 15145000.0 141330.0 146520.0 150450.0 164650.0 149270.0 120700.0 137450.0 135660.0 111230.0 155400.0 True False 133475.4443888162 157757.61286394444 140770.21079757443 142224.38596290778 130517.36810926856 137325.329394491 143841.69735200814 136054.74814027786 133479.1080258701 150913.1982223105 0.8844517640676681 1.0453533204667191 0.9327892620114352 0.9424251002446903 0.8648505872693998 0.909962355924608 0.9531419322259322 0.9015430707382888 0.8844760405199406 1.0 17.203359457751567 -5.682435503549751 2.9159403560003017 0.9157400295131777 0.9679302776700627 0.07677995021877426 0.05126876043073903 0.47153001930888955 8.057476757496298 0.013927207298334009 0.026118293027329625 2.077612245876084e-06 5.682435503549751 0.052190248156885 AYLGYQAVPSGSSGSLSTSSSSS(ph)PPGTPSPADAK ddPTM_A459_Selumetinib_30min_R1 1 AYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAK 34 0 P17676-3;P17676-2;P17676 P17676-3 CEBPB CCAAT/enhancer-binding protein beta 1 AYLGYQAVPSGSSGSLS(0.001)T(0.005)S(0.012)S(0.012)S(0.013)S(0.084)S(0.869)PPGT(0.003)PSPADAK 137.4 7.3529e-26 47095000.0 5134.3 5748.0 6753.5 6891.3 5876.2 4796.1 5566.5 5148.6 2819.5 5172.5 True False 5253.919200391304 5075.0214878272955 5836.41179432009 5687.86382072224 5344.6987475273745 4747.855588510377 5146.614423385141 5012.042402990237 4784.485571867621 5836.44075941662 0.9001923290173957 0.86954047801122 0.999995037198573 0.9745432285156561 0.915746251498251 0.8134847562446514 0.8818070182724805 0.8587498116731017 0.8197608386837894 1.0 12.510873122238241 -6.538367810248753 23.68726121904143 0.866177468424159 0.9370398920701464 0.19143997250576017 0.05867087237536755 184.66410084645804 282401.55405193666 0.0190889745076947 0.019096745368334445 2.89489082449408e-07 6.538367810248753 0.07086242364598738 AYQDQIS(ph)PVPGAPK ddPTM_A459_Selumetinib_30min_R1 1 AYQDQISPVPGAPK 14 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 AYQDQIS(1)PVPGAPK 95.755 0.012276 13028000.0 2173.0 2470.5 2874.7 3185.7 2348.0 2390.2 2378.4 2700.2 1684.9 1864.1 True False 2223.626672078043 2181.2527114957093 2484.331529596797 2629.377297995274 2135.623814573069 2366.156758127959 2198.9953731391747 2628.581924514284 2859.1522397729213 2103.3753928716324 1.057170621855682 1.0370249261677227 1.1811165700693418 1.2500751444113445 1.0153317481086481 1.124933174623463 1.0454602543091451 1.249697002932802 1.3593161969388 1.0 11.038490637871725 -7.772758448264554 24.99212399344032 1.2283799903470853 1.1054545707045682 0.1448310203777845 0.10747595367788647 354.187264300587 782020.7682336036 0.05696571908124412 0.02775915171665026 1.6874913360096654e-08 7.772758448264554 -0.12292541964251713 AYQDTTLNS(ph)SSEYCVEK ddPTM_A459_Selumetinib_30min_R2 1 AYQDTTLNSSSEYCVEK 17 0 X6R717;Q7L7V1-2;Q7L7V1 X6R717 DHX32 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 1 AYQDTTLNS(0.436)S(0.436)S(0.128)EYCVEK 208.38 4.709e-09 4467800.0 21464.0 18935.0 22664.0 23223.0 24465.0 20866.0 16953.0 20554.0 15892.0 23606.0 True False 20271.11680719982 20387.253614378842 21205.822914697415 20059.987338090505 21391.48798012499 23740.102097311083 17741.348091732212 20613.808737102114 19070.84405958035 22924.43344424621 0.8842581369132007 0.8893242079007988 0.9250314938544252 0.8750483359546384 0.9331304972988996 1.035580755138339 0.7739056293312716 0.8992069002375264 0.83190034362079 1.0 14.484598458962951 -10.279264732353761 9.669434809605178 0.9999953972028722 0.896276082532075 0.1953636899083907 0.06431301848860495 0.0 0.0 0.06209767326453288 0.015060897998515468 5.25696720399234e-11 10.279264732353761 -0.1037193146707972 AYQHGGVTGLS(ph)QY ddPTM_A459_Selumetinib_30min_R1 1 AYQHGGVTGLSQY 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 AYQHGGVTGLS(0.999)QY(0.001) 105.19 0.007384799999999999 17985000.0 2318.0 3061.4 2352.2 2913.4 2569.4 2393.0 2437.6 2295.8 1595.3 2069.7 True False 2372.0048899571584 2702.9698647937525 2032.7841597097365 2404.629381291219 2336.9982236644155 2368.9285926701577 2253.7298694769815 2234.9079261906145 2707.1075838980005 2335.366155585224 1.0156886466322679 1.1574073120522763 0.8704348801356749 1.0296584009065757 1.0006988489043949 1.0143713811235409 0.9650434746975319 0.9569839491103546 1.159179076661587 1.0 11.189433048487105 -10.569054988202037 3.9954551942128895 0.9999979566574791 1.0147940040404293 0.002521004359567036 0.08262135426744015 7039705.256422483 18626430.12916467 54.479359634533324 0.019255428264491215 2.6973978797514068e-11 10.569054988202037 0.01479604738295015 AYS(ph)FCGTVEYMAPEVVNR ddPTM_A459_Selumetinib_30min_R1 6 AYSFCGTVEYMAPEVVNR 18 0 B4DG22;B1AXG1;B7ZB17;P51812;E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q9UK32-2;Q9UK32 B4DG22;E9PGT3;Q9UK32-2 RPS6KA3;RPS6KA1;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6 1 AYS(1)FCGTVEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(0.999)FCGT(0.001)VEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR 268.12 7.075599999999998e-54 294689000.0 8988.82 10849.220000000001 9973.58 9589.699999999999 10774.650000000001 9781.95 11270.250000000002 10045.92 5250.23 8290.56 True False 9198.242016801 9578.988278734456 8619.222616953428 7915.038915963618 9800.084809918966 9683.552464299974 10420.125968769675 9779.469567852952 8909.256848372597 9354.734132893002 0.9832713454098341 1.0239722628837664 0.921375476257163 0.8460998253422142 1.0476069838756858 1.0351499387086571 1.1138879866324105 1.0454032609506774 0.9523794820684404 1.0 13.191480936459806 AYS(ph)FCGTVEYMAPEVVNR ddPTM_A459_Selumetinib_30min_R2 7 AYSFCGTVEYMAPEVVNR 18 0 B4DG22;B1AXG1;B7ZB17;P51812;E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q9UK32-2;Q9UK32 B4DG22;E9PGT3;Q9UK32-2 RPS6KA3;RPS6KA1;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6 1 AYS(0.999)FCGT(0.001)VEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(0.878)FCGT(0.122)VEYMAPEVVNR;AYS(1)FCGTVEYMAPEVVNR;AYS(0.999)FCGT(0.001)VEYMAPEVVNR 271.45 4.3236e-54 92437900.0 99765.00000000001 80565.3 103629.8 105600.0 113929.0 88609.8 86344.6 96769.7 82938.7 98647.59999999999 True False 94220.46069093776 86744.39945173067 96962.3714915949 91217.09782983935 99616.22048181739 100814.99563032275 90359.7949885791 97051.28380591366 99528.75750090084 95799.38747075436 0.9835184042246762 0.9054796877298615 1.0121397855617351 0.9521678607567935 1.0398419354427317 1.0523553259784626 0.943218922105991 1.0130678949856697 1.038928954856679 1.0 16.547728811129588 -5.725598352181211 1.5193791569288546 1.0112937623647216 0.9492259179794248 0.25478038789989266 0.03911284952668303 0.5572911647668602 2.5831537258720636 0.012618532072907251 0.02999076289441749 1.8810556660874193e-06 5.725598352181211 -0.06206784438529678 AYS(ph)FCGTVEYMAPEVVNRR ddPTM_A459_Selumetinib_30min_R1 1 AYSFCGTVEYMAPEVVNRR 19 1 B4DG22;B1AXG1;B7ZB17;P51812;Q9UK32-2;Q9UK32 B4DG22;Q9UK32-2 RPS6KA3;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase alpha-6 1 AYS(0.958)FCGT(0.042)VEYMAPEVVNRR 125.03 0.00020394 20637000.0 565.77 568.61 1212.6 1372.4 881.2 638.34 468.42 683.55 544.22 411.32 True False 578.951340203219 502.03687686038234 1047.9355803350177 1132.7361031386238 801.4956155884962 631.9188791663464 433.0867022728942 665.4200335166796 923.5015917438541 464.1169285960837 1.2474256044796732 1.0817034370605774 2.257912857229617 2.4406265605632167 1.7269260529085975 1.3615510235273038 0.9331413606975004 1.4337335971120932 1.989803721526323 1.0 8.858344510330028 -6.744795249173258 5.700278099168188 1.3433779917899853 1.783187145177532 0.16073217517249883 0.4636948843794329 0.3487114574146709 35.544429578823184 0.17449068281677924 0.16710738354032145 1.7997192039271004e-07 6.744795249173258 0.4398091533875468 AYS(ph)GSDLPSSSSGGANGTAGGGGGAR ddPTM_A459_Selumetinib_30min_R1 3 AYSGSDLPSSSSGGANGTAGGGGGAR 26 0 Q8NHG8 Q8NHG8 ZNRF2 E3 ubiquitin-protein ligase ZNRF2 1 AYS(0.915)GS(0.085)DLPSSSSGGANGTAGGGGGAR;AYS(0.492)GS(0.492)DLPS(0.016)SSSGGANGTAGGGGGAR;AYS(0.773)GS(0.227)DLPSSSSGGANGTAGGGGGAR 351.77 6.922599999999994e-216 32518700.0 6662.96 5876.03 7002.4 6623.43 7188.37 6209.2 6841.1900000000005 6440.030000000001 3827.77 5613.24 True False 6818.194004136737 5188.061675907761 6051.512541429921 5466.772287679583 6538.183202709797 6146.741085502522 6325.1535304263325 6269.2194842344 6495.446120740458 6333.7540315877695 1.0764854413564156 0.8191132225902366 0.9554385142286469 0.8631172382785367 1.032276146200578 0.9704736014135417 0.9986421163312398 0.9898110114425785 1.0255286341001397 1.0 12.628845126720515 -6.27438890502086 24.97697771725717 1.0004560630304185 0.9226439249276881 0.2386583038348694 0.06454583598317701 1016.4955434331217 1960607.6457228933 0.01865973405776858 0.02128447994629162 5.316319765735958e-07 6.27438890502086 -0.07781213810273035 AYS(ph)GSDLPSSSSGGANGTAGGGGGAR ddPTM_A459_Selumetinib_30min_R2 2 AYSGSDLPSSSSGGANGTAGGGGGAR 26 0 Q8NHG8 Q8NHG8 ZNRF2 E3 ubiquitin-protein ligase ZNRF2 1 AYS(0.956)GS(0.044)DLPSSSSGGANGTAGGGGGAR;AY(0.002)S(0.684)GS(0.311)DLPS(0.001)SSS(0.001)GGANGTAGGGGGAR 201.85 3.1831999999999996e-32 26341600.0 44653.0 36427.6 46360.9 43923.3 48099.0 38095.0 42942.0 36751.8 35262.6 34688.2 True False 42171.36502012174 39221.47978680472 43378.090167931325 37940.87076808123 42056.37360948423 43342.24045802097 44938.88808795875 36858.741653412006 42316.10531936559 33686.66153523266 1.2518713074614112 1.1643029614490954 1.2876933537199124 1.1262876473644952 1.2484577483434427 1.2866291428935337 1.3340261705944787 1.0941642767082065 1.2561679724512755 1.0 15.039889839020802 -9.696921811606327 0.8189473909718633 0.9928318400728333 1.2299212377366988 0.46787572919840337 0.07258645506364289 8.07522326453409 4.706555718871126 0.2667590018747894 0.023787041402093756 2.0094545530586596e-10 9.696921811606327 0.2370893976638655 AYS(ph)PEYR ddPTM_A459_Selumetinib_30min_R2 2 AYSPEYR 7 0 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;Q9UDY2-5;A0A3B3IRV6;A0A3B3ISF1;A0A3B3ISZ5;A0A3B3IRI3;A0A3B3IT83 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 AYS(1)PEYR;AYS(1)PEYR 101.46 0.019909 93087000.0 365920.0 315630.0 379460.0 373000.0 366730.0 255010.0 277510.0 322500.0 296400.0 346050.0 True False 345583.6312938198 339837.80608959094 355045.95672480937 322196.7565391109 320658.09879220254 290135.31274970295 290414.76487563294 323438.4216072511 355688.28210795415 336058.6373541226 1.0283432499003446 1.0112455634683957 1.056500018925801 0.958751600839217 0.9541730613348536 0.8633472867533298 0.8641788443890156 0.9624463877904352 1.058411368052852 1.0 18.358353458748 -5.877916824279139 5.125861789258898 0.9412902488559155 1.0295410018183315 0.296663756533853 0.055618148699723556 0.2601270792737229 10.586068640800242 0.01707698095151801 0.025877394368800672 1.3245951962825475e-06 5.877916824279139 0.08825075296241602 AYS(ph)SPSTTPEAR ddPTM_A459_Selumetinib_30min_R2 1 AYSSPSTTPEAR 12 0 G3V2R1;Q9UPU9-2;Q9UPU9-3;Q9UPU9 G3V2R1 SAMD4A Protein Smaug homolog 1 1 AYS(0.618)S(0.378)PS(0.001)T(0.001)T(0.002)PEAR 155.48 0.00042638 22603000.0 52790.0 47551.0 57593.0 65650.0 75534.0 48218.0 59280.0 56412.0 43904.0 59487.0 True False 49856.14313511362 51198.0087994364 53887.529082517154 56708.35674743314 66044.74363747229 54859.59182057634 62036.63746109154 56576.149580490644 52686.026780255255 57769.45574421224 0.8630190901548968 0.8862470338326804 0.9328031290638564 0.9816321794431064 1.1432467691906398 0.9496297154586326 1.0738657074384297 0.9793436488478403 0.9120049012324947 1.0 15.818019282418163 -5.59044043714505 2.319426506806124 1.0118728142213829 0.8751414241935832 0.4374289101007478 0.06070247637872382 0.279059612384669 3.005807035884129 0.01784313600672216 0.039464484705135604 2.567790352660304e-06 5.59044043714505 -0.13673139002779966 AYS(ph)TENYSLESQKK ddPTM_A459_Selumetinib_30min_R2 1 AYSTENYSLESQKK 14 1 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AY(0.018)S(0.942)T(0.034)ENY(0.004)S(0.001)LESQKK 76.34100000000002 0.02178 5603800.0 25541.0 28551.0 34070.0 31087.0 25864.0 12340.0 12777.0 16029.0 17396.0 23883.0 True False 24121.53346872392 30740.76989406553 31877.973292611234 26852.89697193383 22614.733092906303 14039.722988633128 13371.155817145185 16075.64173625621 20875.686084851506 23193.435734513787 1.0400155347760334 1.325408199369129 1.3744394602639283 1.1577800408403685 0.97504886088324 0.6053317477126011 0.5765060412006048 0.6931117028226353 0.9000687230562708 1.0 14.501428927433226 -6.421013727226085 2.601969460818866 0.7267792244287951 1.248786190504473 0.685472107937432 0.14838956248560942 0.15327175752272276 2.028260876948243 0.051143178623158 0.05826914651480595 3.793029957348516e-07 6.421013727226085 0.522006966075678 AYSFCGT(ph)VEYMAPEVVNR ddPTM_A459_Selumetinib_30min_R1 2 AYSFCGTVEYMAPEVVNR 18 0 B4DG22;B1AXG1;B7ZB17;P51812;E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q9UK32-2;Q9UK32 B4DG22;E9PGT3;Q9UK32-2 RPS6KA3;RPS6KA1;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6 1 AYS(0.232)FCGT(0.742)VEY(0.026)MAPEVVNR;AYS(0.016)FCGT(0.611)VEY(0.373)MAPEVVNR 154.81 0.00035922 29368000.0 2894.8999999999996 3642.7 3006.1000000000004 3383.8 3600.0 2998.5 3888.7 3337.4 2060.7 2784.3 True False 2962.3455375051685 3216.210990554715 2597.888131325329 2792.882851792827 3274.380635631623 2968.3378124201686 3595.3722281896667 3248.881310596981 3496.8573924268844 3141.692026378676 0.9429140452445193 1.023719372729839 0.8269073192128983 0.88897410323573 1.0422347601670852 0.9448213852589723 1.1444063256365498 1.0341183296511272 1.1130490713494905 1.0 11.617326047791652 -6.802995583781074 1.540766996877857 1.0714211544538288 0.9274757985582901 0.42689699179768237 0.07003462229803538 0.36726845105519296 1.809738452012021 0.031603427953223594 0.027716574392241445 1.5739988699384192e-07 6.802995583781074 -0.1439453558955387 AYSFCGTVEY(ph)MAPEVVNR ddPTM_A459_Selumetinib_30min_R1 2 AYSFCGTVEYMAPEVVNR 18 0 B4DG22;B1AXG1;B7ZB17;P51812;E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q9UK32-2;Q9UK32 B4DG22;E9PGT3;Q9UK32-2 RPS6KA3;RPS6KA1;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6 1 AYS(0.006)FCGT(0.263)VEY(0.731)MAPEVVNR;AYS(0.006)FCGT(0.017)VEY(0.977)MAPEVVNR 182.92 3.2541e-08 39747000.0 4127.1 5173.1 4418.1 4724.3 4455.9 3680.6 4723.5 4507.2 2635.8 3471.5 True False 4223.25340006134 4567.431047091056 3818.146286886146 3899.2896910942877 4052.864631753042 3643.5765057174176 4367.202592088332 4387.654414551064 4472.760088784777 3917.10084027352 1.0781579469795937 1.1660233507728959 0.9747378080313949 0.9954529766004214 1.034659253620349 0.9301717403484044 1.114906858456925 1.120128021581565 1.1418547214302648 1.0 11.935570553591518 AYSGS(ph)DLPSSSSGGANGTAGGGGGAR ddPTM_A459_Selumetinib_30min_R1 1 AYSGSDLPSSSSGGANGTAGGGGGAR 26 0 Q8NHG8 Q8NHG8 ZNRF2 E3 ubiquitin-protein ligase ZNRF2 1 AYS(0.224)GS(0.776)DLPS(0.001)SSSGGANGTAGGGGGAR 391.13 0.0 13145000.0 1272.6 1563.1 1825.0 1481.4 1297.2 1172.1 1760.0 1426.8 737.16 979.29 True False 1302.2491039514573 1380.0915253345242 1577.1750240074264 1222.7012993220335 1179.8684890392612 1160.3097381816513 1627.241783015871 1388.9566291004294 1250.9066799638001 1104.9914105923822 1.1785151372835794 1.2489613150881071 1.4273188088963589 1.1065256142276685 1.0677625886763569 1.050062224067075 1.472628445268649 1.2569840957911287 1.1320510439924536 1.0 10.109819439849892 -8.556657277995653 3.7862396463806665 1.000368372365209 1.2258953358911835 0.22029093850259762 0.13247476142002965 0.3662185068050238 15.832085968075193 0.13572739405075598 0.03565549031215085 2.7755095244957887e-09 8.556657277995653 0.22552696352597446 AYSGS(ph)DLPSSSSGGANGTAGGGGGAR ddPTM_A459_Selumetinib_30min_R2 1 AYSGSDLPSSSSGGANGTAGGGGGAR 26 0 Q8NHG8 Q8NHG8 ZNRF2 E3 ubiquitin-protein ligase ZNRF2 1 AYS(0.136)GS(0.861)DLPS(0.003)SSSGGANGTAGGGGGAR 176.88 2.306e-21 24851000.0 40945.0 34284.0 41045.0 43545.0 40195.0 28306.0 36377.0 33420.0 25724.0 35206.0 True False 38669.440815821676 36913.47255956509 38404.20938641703 37614.09588068515 35145.34475214076 32204.894563715505 38068.60257965802 33517.24666702114 30869.518788613463 34189.51130382667 1.1310322768928722 1.0796724244325053 1.1232745927584706 1.1001647711903733 1.0279569204666317 0.9419524683323263 1.1134585177705416 0.9803371089211712 0.9028944144386872 1.0 15.061266180952387 -6.343482435565423 3.339003519056281 0.9936315647755359 1.108614258262949 0.5423925222699355 0.05219208041843969 0.21437073950710464 4.6198392559710975 0.017273717818086377 0.02022748098261865 4.534376360609252e-07 6.343482435565423 0.11498269348741308 AYSS(ph)PSTTPEAR ddPTM_A459_Selumetinib_30min_R1 2 AYSSPSTTPEAR 12 0 G3V2R1;Q9UPU9-2;Q9UPU9-3;Q9UPU9 G3V2R1 SAMD4A Protein Smaug homolog 1 1 AYS(0.017)S(0.977)PS(0.003)T(0.003)TPEAR;AYS(0.021)S(0.866)PS(0.04)T(0.072)TPEAR 191.79 0.00014495 64357000.0 10370.9 11102.2 12200.6 12314.5 11212.099999999999 10526.0 10568.599999999999 9787.3 6005.4 7834.0 True False 10612.521791741457 9802.349262727252 10543.82553309864 10164.003746794366 10197.967534657037 10420.117996843323 9771.401993171325 9527.709010369108 10190.725182938042 8839.570209622001 1.2005698851952749 1.108916953004938 1.1927984373744247 1.149830082884652 1.1536723271405662 1.1788036917791402 1.1054159604428517 1.0778475405962678 1.1528530167502136 1.0 13.109760510441616 -11.172221733845717 0.20371985153964706 0.8463835414650343 1.182931649591238 0.6624257509164457 0.033581901836286544 16.438674274781096 0.5649942627324139 1.3399296454959648 0.08895240581684867 6.7263314831592305e-12 11.172221733845717 0.33654810812620384 AYSS(ph)PSTTPEAR ddPTM_A459_Selumetinib_30min_R2 1 AYSSPSTTPEAR 12 0 G3V2R1;Q9UPU9-2;Q9UPU9-3;Q9UPU9 G3V2R1 SAMD4A Protein Smaug homolog 1 1 AYS(0.411)S(0.572)PS(0.006)T(0.004)T(0.008)PEAR 164.9 0.00051451 20799000.0 74264.0 63348.0 73508.0 86621.0 96652.0 69488.0 61173.0 71399.0 64210.0 70600.0 True False 70136.70418234653 68206.58790407555 68778.57530945895 74823.07037044036 84509.71168015688 79059.34125074047 64017.665711999914 71606.75926925917 77053.79417730018 68561.59455917073 1.022973643383052 0.9948220770333923 1.0031647564745736 1.0913262862617028 1.2326100672472318 1.1531140977549739 0.9337248662842976 1.0444150216993622 1.123862341194536 1.0 16.06511304261504 -5.760938206562297 24.972214895097583 1.0875425937689331 1.0057703332139214 0.16460265872479451 0.07764266174893338 24.50235115997971 1220736.4740042656 0.02348641402277074 0.03773221044453414 1.7340507089977194e-06 5.760938206562297 -0.08177226055501174 AYSSFGGGRGS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 AYSSFGGGRGSR 12 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 1 AYSSFGGGRGS(1)R;AYSSFGGGRGS(1)R 90.853 0.013111 27552000.0 71143.0 76995.0 76926.0 78949.0 93316.0 53001.0 58060.0 57982.0 41949.0 66849.0 True False 67189.15686799363 82900.26892205433 71976.66491069613 68196.01000537847 81592.80982437546 60301.406654825274 60759.90504370744 58150.71802056318 50339.972152991235 64918.89567543906 1.0349707303079323 1.276982118372944 1.1087167174029309 1.050480130566658 1.2568422333044198 0.9288729579797714 0.9359355918109817 0.8957441037088297 0.7754286580083724 1.0 15.986350838198144 -6.858397294028041 6.763658235382197 0.8991962591403571 1.1450119354954509 0.6417557830629594 0.08913435938186055 0.13662672012493654 8.154568361047097 0.030756353041645437 0.02716106292055614 1.3854878001411927e-07 6.858397294028041 0.24581567635509383 AYST(ph)ENYSLESQK ddPTM_A459_Selumetinib_30min_R2 2 AYSTENYSLESQK 13 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 AYS(0.274)T(0.726)ENYSLESQK;AYS(0.297)T(0.702)ENYS(0.001)LESQK 169.17 0.00061007 34033000.0 132000.0 122684.0 169897.0 146777.0 146903.0 74507.0 96982.0 107084.0 116763.0 143828.0 True False 124663.96843786685 132093.46830876445 158966.01198986697 126785.71939555198 128447.7318105171 84769.6629427947 101491.85516618716 107395.5967112894 140118.86263080672 139675.31192997762 0.892526866167757 0.9457180834862634 1.138111021864481 0.9077174601844635 0.9196165738646128 0.6069051271229067 0.7266270163553836 0.7688946258815533 1.0031755841078878 1.0 17.091717516631952 -6.537480085758262 24.990401748226457 0.7966027746879758 0.9727114969149956 0.22533243060560026 0.1282309438683692 306.9004648476452 525260.9426027358 0.042926749277047975 0.04294316967125372 2.900814210263423e-07 6.537480085758262 0.1761087222270198 AYT(ph)HQVVTR ddPTM_A459_Selumetinib_30min_R1 3 AYTHQVVTR 9 0 D6R9G1;D6RAD4;P50613;D6REC6 D6R9G1 CDK7 Cyclin-dependent kinase 7 1 AY(0.002)T(0.998)HQVVTR;AYT(1)HQVVTR;AYT(1)HQVVTR 114.76 0.011362 150283000.0 18780.0 3798.3999999999996 14972.2 7598.5 16442.300000000003 7167.400000000001 15156.0 9039.3 11397.199999999999 14898.9 True False 19217.537460481217 3353.6815621717474 12939.05747640768 6271.564616510373 14955.09686812385 7095.30246347851 14012.770717834403 8799.548400215524 19340.215981446927 16811.3189425756 1.1431308588055953 0.19948949714340156 0.7696634345350974 0.37305607239580035 0.8895849825470408 0.4220550741863128 0.8335319058367444 0.5234299837075947 1.1504282351378603 1.0 14.037145296108488 -8.264029948547039 24.98726425281595 1.0752141681892555 0.6316402095176588 0.29459769385762746 0.2661838853063998 261.1396975788794 2518736.7679533563 0.19826993011841743 0.06035600948673932 5.444651057361514e-09 8.264029948547039 -0.44357395867159677 AYT(ph)HQVVTR ddPTM_A459_Selumetinib_30min_R2 4 AYTHQVVTR 9 0 D6R9G1;D6RAD4;P50613;D6REC6 D6R9G1 CDK7 Cyclin-dependent kinase 7 1 AYT(0.998)HQVVT(0.002)R;AYT(1)HQVVTR;AY(0.001)T(0.999)HQVVTR;AYT(1)HQVVTR 134.75 0.006564100000000001 237531000.0 115461.0 95202.0 101752.0 154200.0 138336.0 66093.0 109037.0 104150.0 102635.0 99599.0 True False 109044.13984700416 102503.6872773224 95205.38709920103 133197.69399016295 120956.99494046891 75196.71081748216 114107.43655271664 104453.05925703935 123164.86786150456 96723.31808072004 1.1273821247116629 1.0597618993155133 0.984306462891893 1.3771001309012514 1.2505463764128186 0.7774413896215498 1.1797303775030625 1.0799160050513206 1.273373063553484 1.0 16.561576116449253 -10.764745120654037 4.9633522383243385 0.9999795016138994 1.11874929798784 0.0509467623846146 0.15854679165688004 3.637355417925369e-05 5.555648656944577e-06 0.15525580750643966 0.03764856712600659 1.7189168915141644e-11 10.764745120654037 0.11876979637394058 AYT(ph)PPPPLGPHPNLGK ddPTM_A459_Selumetinib_30min_R2 2 AYTPPPPLGPHPNLGK 16 0 J3QS41;P42694 J3QS41 HELZ Probable helicase with zinc finger domain 1 AY(0.011)T(0.989)PPPPLGPHPNLGK;AY(0.075)T(0.925)PPPPLGPHPNLGK 124.42 0.0017475 94421000.0 257492.0 231845.0 250124.0 240609.0 257406.0 209417.0 232495.0 221219.0 150748.0 242585.0 True False 243181.6254621454 249626.7660008272 234031.29415442003 207837.63912632363 225068.3570411631 238262.2908517489 243306.47818010265 221862.71066522313 180901.81225104549 235580.9407384766 1.0322635808306178 1.0596220781626946 0.9934220205624492 0.8822345240443223 0.9553759159617936 1.0113818635109744 1.0327935588397295 0.9417685062711317 0.7678966374952565 1.0 17.845863299622422 -5.519863147517454 7.712521567714995 0.9457623079950946 1.0414636123932386 0.25537119654511276 0.071428808983974 0.17876637767564343 84.15261264416434 0.020091146890666715 0.03751605966879532 3.020903500888922e-06 5.519863147517454 0.09570130439814395 AYT(ph)PVVVTLWYR ddPTM_A459_Selumetinib_30min_R1 2 AYTPVVVTLWYR 12 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12 P21127 CDK11B Cyclin-dependent kinase 11B 1 AYT(1)PVVVTLWYR;AYT(0.955)PVVVT(0.045)LWYR 234.49 3.7944e-10 475000000.0 7322.7 8934.5 6081.5 6659.700000000001 6385.9 6337.9 6924.6 7425.299999999999 4143.9 7511.900000000001 True False 7493.30466250616 7888.444586463633 5255.665703288311 5496.708413051805 5808.296472522218 6274.14648035277 6402.271846972559 7228.3569232263935 7031.89564151879 8476.12553710231 0.8840483343133515 0.930666322948352 0.6200551986025726 0.6484930395368986 0.6852537102120211 0.7402139636664324 0.7553299935150878 0.852790215480635 0.8296120215230729 1.0 13.049189239811263 -8.552798654411134 0.9796483921051219 0.9955227338045277 0.7465838318923992 0.38540658255147664 0.09328329413944705 0.7029521985704348 1.4791769736097626 0.0989038016949937 0.03310723429707086 2.8002792711944873e-09 8.552798654411134 -0.24893890191212853 AYT(ph)PVVVTLWYR ddPTM_A459_Selumetinib_30min_R2 1 AYTPVVVTLWYR 12 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12 P21127 CDK11B Cyclin-dependent kinase 11B 1 AYT(1)PVVVTLWYR 196.7 0.00035938 84439000.0 184250.0 100390.0 113380.0 161060.0 135740.0 136770.0 180450.0 147530.0 129090.0 139230.0 True False 174010.12261118912 108089.59019527308 106085.25423880998 139123.3501560027 118687.12766900331 155608.8260255551 188841.2825548915 147959.28787509378 154911.60707596468 135210.0681370158 1.2869612818688552 0.799419685860523 0.7845958196789603 1.0289422383473794 0.8777980020595146 1.1508671519037186 1.3966510420180267 1.0942919407832743 1.1457105910114935 1.0 17.04484305734784 -6.824136688598971 6.700477965647262 1.180494011501758 0.9417254868419409 0.27198720907816687 0.16256684290411808 0.2530618928220155 21.235769664760284 0.05695287433130746 0.050476855908106404 1.4992129032719777e-07 6.824136688598971 -0.23876852465981702 AYT(ph)PVVVTQWYR ddPTM_A459_Selumetinib_30min_R1 1 AYTPVVVTQWYR 12 0 Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 Q5QPR4 CDK11A Cyclin-dependent kinase 11A 1 AYT(1)PVVVTQWYR 149.57 0.001339 96058000.0 1807.1 2080.1 1435.0 1685.4 1397.7 1704.3 1889.9 1729.9 1030.3 1710.6 True False 1849.2019139955044 1836.5609249877452 1240.1348818907709 1391.076528876302 1271.278281783978 1687.1562893805883 1747.34332143278 1684.0174324928757 1748.343849865299 1930.1721726550152 0.9580502403844453 0.9515010893880494 0.6424996171118376 0.720700748142499 0.6586346543558821 0.8740962662723758 0.9052784752508642 0.8724700606249309 0.9057968375227349 1.0 10.914513827262615 -6.9820581426828445 24.657697972622096 0.907320093642567 0.7820795400743767 0.2710507472393009 0.1039078812708613 325.6508708056114 447543.7861024273 0.04014221815575471 0.03539547517732238 1.0421778948661589e-07 6.9820581426828445 -0.1252405535681903 AYT(ph)PVVVTQWYR ddPTM_A459_Selumetinib_30min_R2 3 AYTPVVVTQWYR 12 0 Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 Q5QPR4 CDK11A Cyclin-dependent kinase 11A 1 AY(0.007)T(0.992)PVVVT(0.002)QWYR;AYT(1)PVVVTQWYR;AY(0.001)T(0.998)PVVVT(0.001)QWYR 120.59 0.0093425 63398700.0 67763.0 52904.0 63259.0 70749.0 68847.0 53358.0 64891.0 70236.0 49366.0 51569.0 True False 63997.00373678168 56961.56668682857 59188.98481119148 61112.86415116758 60197.824360010876 60707.58016430194 67908.56007907707 70440.37513180428 59240.57940128646 50080.06897764694 1.277893681922573 1.1374099087653646 1.1818870464737234 1.220303114567296 1.2020315784085673 1.2122103943466722 1.3559997313379863 1.406555074100339 1.1829172884671602 1.0 15.611948928913444 -7.0297986205325005 23.966960044498453 1.272227266069002 1.2006208787458206 0.0 0.10856002589695421 1067.1930739174052 858337.1653822934 0.03963782693269935 0.030764723767195495 9.336871449650959e-08 7.0297986205325005 -0.07160638732318136 AYTNFDAER ddPTM_A459_Selumetinib_30min_R2 2 AYTNFDAER 9 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ; 178.55 0.011914 285950000.0 1285140.0 1030070.0 1235510.0 1364230.0 1219690.0 771590.0 1135010.0 1179370.0 825230.0 939470.0 False True 1213717.063623034 1109073.0568029177 1156018.6317215755 1178419.520571982 1066461.6380330545 877869.5187033575 1187790.2139796473 1182801.7714447854 990299.0588527236 912345.0600637976 1.330326777390741 1.2156289383814536 1.2670848808462212 1.2916379691797515 1.1689235627126429 0.9622121685428654 1.3019089662156866 1.296441251473511 1.085443547843044 1.0 19.799220046952755 -14.522878743844592 0.0635197974095065 0.27320730228948625 1.5057098916600071 0.35170035446714654 0.10178301124898502 485.623897640554 2.233962828479565 54.20904738438743 8.113430177982302 3.0000000099177812e-15 14.522878743844592 1.2325025893705208 CAAPRPPSSS(ph)PEQR ddPTM_A459_Selumetinib_30min_R1 1 CAAPRPPSSSPEQR 14 1 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 CAAPRPPS(0.003)S(0.099)S(0.898)PEQR 165.78 0.0011625 9673200.0 2599.7 2181.4 2935.6 2294.8 2601.3 2633.4 2877.4 2581.1 1817.2 2822.4 True False 2660.2679518643754 1926.000673894653 2536.961644096551 1894.0562587310674 2366.012874296818 2606.9103869358933 2660.3554013919693 2512.640843405606 3083.6556769632352 3184.6825325041004 0.8353322269057128 0.6047700686762796 0.796613671285392 0.5947394251702006 0.7429352377037198 0.818577789254897 0.8353596863233161 0.7889768659075506 0.9682772601319767 1.0 11.636933848161027 -7.920915499046291 0.6541691287224054 1.0042595630841769 0.7047295191024573 0.6007232060732285 0.0786120633254969 0.46525331613677134 0.4165635073838772 0.0721620180948849 0.03547439573494655 1.1997327131987326e-08 7.920915499046291 -0.29953004398171956 CAAPRPPSSS(ph)PEQR ddPTM_A459_Selumetinib_30min_R2 1 CAAPRPPSSSPEQR 14 1 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 CAAPRPPS(0.001)S(0.387)S(0.612)PEQR 109.44 0.021678 7835400.0 8331.7 7260.3 8786.7 11121.0 10125.0 7757.4 8912.9 8046.3 7417.3 8941.2 True False 7868.6574684376965 7817.141664456021 8221.373288235607 9606.300615204942 8853.00698135154 8825.911435334076 9327.3675105763 8069.713400863329 8900.967256677917 8683.044323972481 0.9062095245458561 0.9002766049315397 0.9468307406352545 1.1063286396780792 1.0195740861197518 1.0164535738884992 1.0742047561389207 0.9293645292796855 1.0250975262332573 1.0 13.083985232985368 -5.535386007100556 23.8189419582439 1.0233010203529265 0.908320696117805 0.569318542696437 0.04357171931025065 86.41213993772715 164563.22741755133 0.011931028471790239 0.020687176909508134 2.914835115485431e-06 5.535386007100556 -0.1149803242351215 CADTRPGSEQPPLGGAAS(ph)PEVLAPVSK ddPTM_A459_Selumetinib_30min_R1 1 CADTRPGSEQPPLGGAASPEVLAPVSK 27 1 Q96RY5 Q96RY5 CRAMP1L Protein cramped-like 1 CADTRPGSEQPPLGGAAS(0.997)PEVLAPVS(0.003)K 86.508 3.0107e-05 4554700.0 832.2 944.65 1163.7 1136.2 1018.9 858.23 1238.1 1278.4 625.94 1032.7 True False 851.5886408206851 834.0499388441294 1005.6759317465437 937.7839991154947 926.7406749014052 849.5969854104928 1144.7091201999717 1244.492679171566 1062.1744631512036 1165.2571043498383 0.7308160899785577 0.7157647318610362 0.8630506761060823 0.8047871972758635 0.795310040541212 0.7291068917228616 0.9823661369897149 1.0679983623579257 0.9115365692139245 1.0 10.186432593401666 -7.272851500271888 22.043283357125222 0.9961419335894542 0.7770645292917514 0.7947630691332515 0.054053356754637204 68.33297144028026 131987.8747028007 0.022842736186463243 0.01560221526730203 5.335172916091208e-08 7.272851500271888 -0.21907740429770284 CADTRPGSEQPPLGGAAS(ph)PEVLAPVSK ddPTM_A459_Selumetinib_30min_R2 1 CADTRPGSEQPPLGGAASPEVLAPVSK 27 1 Q96RY5 Q96RY5 CRAMP1L Protein cramped-like 1 CADTRPGSEQPPLGGAAS(0.994)PEVLAPVS(0.006)K 107.98 9.4092e-10 6001300.0 37568.0 29143.0 34763.0 39833.0 41891.0 32183.0 33838.0 38297.0 33407.0 31796.0 True False 35480.120956619576 31378.17439048551 32526.386427092613 34407.67668424229 36628.27806970841 36615.91612181359 35411.534048724985 38408.43792959034 40089.333469569676 30877.966864070677 1.149043300448124 1.0161994968327035 1.053384977394351 1.1143116007511087 1.1862270022813173 1.1858266537755613 1.1468220755793843 1.243878461903593 1.2983151917368387 1.0 14.914290142139654 -6.102129456308787 2.82755697100478 1.188573759470758 1.067830207261754 0.2553925036064889 0.07875873466547102 0.32549588494858855 5.045827221606763 0.02388002649013123 0.03321585419704766 7.904429743438427e-07 6.102129456308787 -0.1207435522090039 CALS(ph)SPSLAFTPPIK ddPTM_A459_Selumetinib_30min_R2 1 CALSSPSLAFTPPIK 15 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 CALS(0.554)S(0.418)PS(0.024)LAFT(0.005)PPIK 80.312 0.029422000000000007 8404100.0 42887.0 34225.0 42912.0 50113.0 45221.0 35642.0 40107.0 40428.0 31865.0 39570.0 True False 40503.51223026361 36849.94744927995 40151.08863905295 43287.522950253166 39539.93369913068 40551.36197413788 41972.054970512785 40545.63878678431 38238.89038248982 38427.51128479298 1.0540238198119318 0.9589470204348799 1.0448526926837973 1.1264721940862055 1.0289485937846286 1.055269014784868 1.0922397409358773 1.0551200801502214 0.995091513970154 1.0 15.229851924429196 -5.500973478639792 24.66040934333216 1.0562432950263128 1.0053390152386856 0.13144026180247137 0.04289560568497043 1006.1571703666233 1132705.821418999 0.010912371977276087 0.02239346013843154 3.155197298097731e-06 5.500973478639792 -0.05090427978762713 CALSS(ph)PSLAFTPPIK ddPTM_A459_Selumetinib_30min_R1 1 CALSSPSLAFTPPIK 15 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 CALS(0.242)S(0.661)PS(0.095)LAFT(0.001)PPIK 168.89 6.305199999999999e-05 13619000.0 4102.5 4128.1 4820.8 5015.9 5090.6 4569.9 4323.6 5027.6 2672.5 3870.5 True False 4198.080267924609 3644.780132898375 4166.161838758907 4139.9672251042175 4630.156128818429 4523.930955137211 3997.467371049668 4894.2517160536345 4535.037308322829 4367.316376862644 0.9612494048210886 0.8345583004262864 0.9539409283079601 0.9479430542374062 1.0601833550113908 1.0358605983079876 0.9153143546521206 1.1206542631036789 1.0384036595903023 1.0 12.092531331190802 -5.932070507005249 2.0325166295585055 1.0288199215337666 0.9023886445916506 0.43288422048309716 0.05836972123679344 0.2932194689951063 2.455293072194123 0.01831557933247784 0.030721305413465193 1.169309540100631e-06 5.932070507005249 -0.12643127694211598 CALSSPSLAFT(ph)PPIK ddPTM_A459_Selumetinib_30min_R1 1 CALSSPSLAFTPPIK 15 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 CALSS(0.002)PS(0.338)LAFT(0.66)PPIK 160.78 0.00029479 13071000.0 5490.3 5167.1 6204.4 6327.9 5769.0 5363.2 5726.3 5999.9 3457.2 5611.5 True False 5618.21330773589 4562.1335298803815 5361.876558329689 5222.85105439442 5247.194968599676 5309.251077395985 5294.360580729419 5840.763161578126 5866.615896102407 6331.790685638736 0.8873024372834488 0.7205123726259381 0.8468183527435723 0.8248616092506778 0.8287063216573072 0.8385070418448932 0.8361553379737688 0.9224504491005491 0.9265334543367958 1.0 12.628397848762852 -8.10502858309869 0.7974324597482217 0.9989329121215506 0.8139310366615127 0.6755087315325883 0.040857950857603985 0.32438032901242553 0.4240171359051012 0.036429133098214286 0.014668645818769017 7.851839560140984e-09 8.10502858309869 -0.18500187546003788 CALSSPSLAFT(ph)PPIK ddPTM_A459_Selumetinib_30min_R2 1 CALSSPSLAFTPPIK 15 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 CALSSPS(0.009)LAFT(0.991)PPIK 124.51 0.0030792 12037000.0 64265.0 47514.0 59760.0 60690.0 76097.0 57894.0 65598.0 58713.0 59865.0 57235.0 True False 60693.40857317818 51158.17101841018 55915.106661768354 52423.917303910464 66537.01454418847 65868.37299059363 68648.43697997113 58883.84510953959 71839.67276785671 55582.476835610934 1.0919522127933088 0.9204010675831171 1.005984436914195 0.9431734656042383 1.197086174136794 1.1850564555696925 1.235073370029977 1.059395846710694 1.2924877921566462 1.0 15.762342504099362 -6.264408774650396 24.97765372368609 1.1693412337812388 0.9864942151044725 0.46927502990990355 0.08888939030251179 205.7525191427218 1730723.3281760039 0.025213759814508352 0.029822346562873803 5.439903871476318e-07 6.264408774650396 -0.18284701867676623 CAPPS(ph)PPPPVEPATQEEAER ddPTM_A459_Selumetinib_30min_R1 1 CAPPSPPPPVEPATQEEAER 20 0 Q6IQ19;Q6IQ19-3;Q6IQ19-4 Q6IQ19 CCSAP Centriole, cilia and spindle-associated protein 1 CAPPS(1)PPPPVEPATQEEAER 84.829 0.0025045 2656400.0 431.15 423.77 684.51 418.97 439.08 487.49 640.25 471.98 275.54 547.53 True False 441.1949561281399 374.1548113946718 591.557301744287 345.8047545409422 399.36529152587013 482.58629320550557 591.9554270317676 459.4615571928936 467.57125535463894 617.8108088938385 0.7141263146853629 0.6056138966952983 0.957505587840787 0.5597259704149391 0.6464200460346673 0.7811230982985776 0.9581500007933436 0.7436929729596965 0.7568194803710273 1.0 9.271021301596743 -6.987576754130066 8.363955605914017 0.8470926172606971 0.6997892362711902 0.2873883390400118 0.1234980573181371 0.2314243694380195 109.43856619620198 0.04400286759301103 0.03797873830181579 1.0290186496567488e-07 6.987576754130066 -0.1473033809895069 CAPSAGS(ph)PAAAVGR ddPTM_A459_Selumetinib_30min_R1 3 CAPSAGSPAAAVGR 14 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 CAPS(0.002)AGS(0.998)PAAAVGR;CAPS(0.048)AGS(0.952)PAAAVGR;CAPS(0.002)AGS(0.998)PAAAVGR 172.58 0.00012009 114572000.0 5006.700000000001 4277.2 5109.8 4900.8 4742.6 3999.26 4782.7 4726.2 2940.77 4429.1 True False 5123.346368657681 3776.4234355836647 4415.917226122276 4044.9672794096273 4313.63266737404 3959.031075437545 4421.937088426139 4600.8458231388095 4990.271904657259 4997.618128087412 1.025157632565733 0.7556446568735539 0.883604371711419 0.8093790233143796 0.8631377101685171 0.7921835910565392 0.8848089179871801 0.9206077185612325 0.9985300550698611 1.0 12.287024952840945 -7.987033180645705 1.914657792454449 1.0022617188525036 0.8499850420594597 0.4022164503774669 0.06823260908566588 0.3246779651478341 2.171469635275685 0.05376938357230622 0.018115812480114422 1.0303074006507304e-08 7.987033180645705 -0.1522766767930439 CAPSAGS(ph)PAAAVGR ddPTM_A459_Selumetinib_30min_R2 3 CAPSAGSPAAAVGR 14 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 CAPS(0.006)AGS(0.994)PAAAVGR;CAPS(0.01)AGS(0.99)PAAAVGR;CAPS(0.03)AGS(0.97)PAAAVGR 160.46 0.00029051 112868600.0 56925.0 46378.0 59531.0 72258.0 82324.0 58078.0 61730.0 65184.0 57732.0 54326.0 True False 53761.33638883013 49935.04347122592 55700.84027245201 62416.33574799743 71981.72313410221 66077.71732040796 64600.56731567447 65373.67464820791 69280.01316685718 52757.46722410063 1.019028001485843 0.9465019095612428 1.0557906435471716 1.1830805956409607 1.3643892878394204 1.252480848629943 1.2244819684248163 1.2391359572004617 1.3131792864993477 1.0 15.687087685023302 -5.738967859701867 2.8112660042503688 1.2464975816661121 0.986357420955983 0.5513931540546092 0.09150752433270169 0.16993728984919168 2.7390197391892706 0.02501995551413002 0.045246195815349666 1.824030686122708e-06 5.738967859701867 -0.26014016071012913 CAPSAGS(ph)PAAAVGRES(ph)PGAAATSSSGPQAQQHR ddPTM_A459_Selumetinib_30min_R2 2 CAPSAGSPAAAVGRESPGAAATSSSGPQAQQHR 33 1 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 2 CAPS(0.095)AGS(0.908)PAAAVGRES(0.983)PGAAAT(0.009)S(0.004)S(0.001)SGPQAQQHR;CAPS(0.18)AGS(0.914)PAAAVGRES(0.892)PGAAAT(0.011)S(0.002)S(0.001)S(0.001)GPQAQQHR 69.57600000000001 8.0428e-05 20776000.0 23692.0 23004.3 33160.0 39761.0 44972.0 25212.0 20302.6 25483.0 25246.5 30188.0 True False 22375.293486590468 24768.655839517065 31026.521701878148 34345.48320844924 39322.2153052189 28684.72414825107 21246.711128838695 25557.15131106224 30296.505446148723 29316.394002156456 0.7632348468554688 0.8448738899366386 1.058333494207913 1.1715452864333469 1.341304640070209 0.9784533577404192 0.7247382173699749 0.8717699492366731 1.0334321964672795 1.0 14.839420038439139 -7.004462228095732 24.97989539468575 0.8903416015665786 1.0466193378208735 0.10939474479368383 0.16848157369393338 408.16004561305544 2284920.2617067173 0.06704286421663752 0.05767073850608634 9.897779441063118e-08 7.004462228095732 0.15627773625429486 CAPSAGSPAAAVGRES(ph)PGAAATSSSGPQAQQHR ddPTM_A459_Selumetinib_30min_R1 2 CAPSAGSPAAAVGRESPGAAATSSSGPQAQQHR 33 1 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 CAPSAGS(0.001)PAAAVGRES(0.98)PGAAAT(0.005)S(0.006)S(0.006)S(0.002)GPQAQQHR;CAPSAGSPAAAVGRES(0.869)PGAAAT(0.086)S(0.031)S(0.011)S(0.004)GPQAQQHR 103.88 3.5898e-12 10488400.0 833.4 589.15 664.64 568.85 898.92 736.87 808.9200000000001 774.21 264.14 620.6099999999999 True False 852.8165984858911 520.1720441115957 574.38553860619 469.51102613699123 817.6128447172157 729.4577568244287 747.9025131347718 753.6754358114971 448.2262879776958 700.2713387533197 1.2178373600212524 0.7428149851708176 0.8202328252199471 0.6704701451480981 1.1675657698240185 1.0416787271674848 1.0680181691660393 1.0762620060293369 0.6400751582603179 1.0 9.451770230722905 -6.266230971991539 24.99071774386865 1.008337911494031 0.8512224140229057 0.11024565325813995 0.18711439584158449 837.3647492886444 4367297.671527034 0.05709479523528872 0.06684275479533569 5.417127132616575e-07 6.266230971991539 -0.1571154974711253 CAPSAGSPAAAVGRES(ph)PGAAATSSSGPQAQQHR ddPTM_A459_Selumetinib_30min_R2 1 CAPSAGSPAAAVGRESPGAAATSSSGPQAQQHR 33 1 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 CAPSAGSPAAAVGRES(0.983)PGAAAT(0.009)S(0.003)S(0.003)S(0.003)GPQAQQHR 86.89 1.3515999999999997e-08 6213200.0 9542.4 6191.8 7948.1 11055.0 10931.0 7940.3 8110.5 6696.6 8485.8 9378.6 True False 9012.071609253795 6666.691150225033 7436.727899236966 9549.289929061297 9557.750055620118 9034.004250133192 8487.654320650858 6716.085997318194 10183.197113062362 9107.815449470792 0.9894877272439068 0.7319747734471717 0.8165215841817562 1.048472049311908 1.049400935783725 0.9918958393758528 0.9319089048015384 0.7373981208313165 1.1180724038116139 1.0 13.152889343283004 -5.745920883844336 24.988141660112873 0.9725853590678065 0.8345926502177977 0.232180607355427 0.11214609692835306 360.1207843529682 579867.7860672737 0.030844528948506696 0.053183052515378706 1.7950606062559302e-06 5.745920883844336 -0.1379927088500088 CCS(ph)PPNELGFR ddPTM_A459_Selumetinib_30min_R2 1 CCSPPNELGFR 11 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 CCS(1)PPNELGFR 106.26 0.011224 3120500.0 28184.0 22470.0 29942.0 25851.0 28453.0 20807.0 20440.0 17682.0 16365.0 22351.0 True False 26617.64610949122 24193.376747562335 28015.56431838468 22330.049204537634 24878.479766952634 23672.97538285974 21390.500501091614 17733.451692587325 19638.457276304598 21705.66855512781 1.2262992978948344 1.1146109914152735 1.2907026681638978 1.0287657875095637 1.1461743140399732 1.0906356246404199 0.9854799195318156 0.8169963365812993 0.9047616859359604 1.0 14.40578423919683 -7.249780568295036 1.8734535535364125 0.8948302235833361 1.1599829959560286 0.6757212299048333 0.07755938119116566 0.19639295485020553 1.3459532394403266 0.03933809856249771 0.024909467250161684 5.6262552565701835e-08 7.249780568295036 0.2651527723726925 CCSGAIIVLT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 CCSGAIIVLT(1)K 142.91 0.0020645 19309000.0 3699.4 3555.6 4765.6 4761.0 4137.4 3677.4 3695.2 4538.4 2350.3 3658.8 True False 3785.588822220672 3139.3086990464053 4118.457695567014 3929.5807250386115 3763.172900517296 3640.4086948120475 3416.46808897741 4418.026889199183 3988.287440879757 4128.442619730019 0.9169532365859142 0.7604099143932638 0.9975814308002522 0.9518312562366648 0.911523605180539 0.88178740269136 0.8275440410991666 1.0701437069962476 0.9660513196476429 1.0 12.011381938334411 -7.764342993587908 24.99959386016013 1.013573133947028 0.8940779334752923 0.41106500271834256 0.06554679322916328 78.5172250087763 675993.0074583577 0.03463280853992271 0.01778198174343161 1.7205092283887758e-08 7.764342993587908 -0.11949520047173567 CCSGAIIVLT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 CCSGAIIVLT(1)K 105.65 0.019439 0.0 30472.0 21578.0 17388.0 27968.0 20316.0 21196.0 30502.0 28228.0 18118.0 19195.0 True False 28778.488229080904 23232.963215794392 16269.275010622967 24158.710152508957 17763.722452655602 24115.556601869343 31920.403438566384 28310.138806603045 21742.10625921702 18640.790475400576 1.5438448421518711 1.2463507514047703 0.8727781706517654 1.2960131805778374 0.9529489898026373 1.2936981741033768 1.7123953772609763 1.5187198656603473 1.1663725466958663 1.0 14.186175419303444 -6.998667542505315 24.98888826385413 1.408376918771643 1.1698798417069285 0.07180385349957497 0.25037496902334977 82.11545800358282 1539952.6738557483 0.0883278794174782 0.07732087895289912 1.0030728081903264e-07 6.998667542505315 -0.23849707706471457 CCSGAIIVLTK ddPTM_A459_Selumetinib_30min_R2 2 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 164.43 0.0090185 9165100.0 62537.0 52857.0 59533.0 62876.0 63794.0 50364.0 57692.0 56847.0 46780.0 56272.0 False True 59061.443895446064 56910.96193795737 55702.711594629414 54312.180332850156 55779.62739440401 57301.18384112793 60374.792314529244 57012.41535847251 56137.307142409336 54647.28114778543 1.0807755235932635 1.041423484254416 1.0193135033377 0.9938679325321046 1.020720998791437 1.0485642219997262 1.104808712280756 1.0432799978518772 1.0272662420403744 1.0 15.73786209919444 -6.836188571690299 7.352151488857055 1.0514277519933948 1.029090144676408 0.02079836900495602 0.032215697829969865 0.6147115703023485 50.997493950203484 0.011906757938513418 0.010523157130570665 1.4581809771727565e-07 6.836188571690299 -0.02233760731698675 CDENILWLDYK ddPTM_A459_Selumetinib_30min_R2 1 CDENILWLDYK 11 0 P14618;P14618-3;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 176.8 0.00094653 3505200.0 29578.0 28188.0 31734.0 34342.0 32125.0 23810.0 29958.0 29601.0 24842.0 30036.0 False True 27934.173170115348 30349.928961294485 29692.26898936675 29664.560356745653 28089.17029885615 27089.611374339907 31351.106360650832 29687.134009290658 29811.094143474405 29168.782637099866 0.9576736032372426 1.040493507695872 1.0179468015096749 1.0169968601643047 0.9629874050050153 0.9287192993746864 1.0748170998667343 1.0177707578214628 1.022020511255673 1.0 14.83213755597862 -7.279086638338921 24.991755495818715 1.030132979385193 0.9914944024944808 0.2368808008877964 0.03573728171687849 1453.959770509965 2059065.4498120586 0.015730570788804583 0.0106334174949126 5.259123405428061e-08 7.279086638338921 -0.03863857689071215 CDGDAS(ph)PPSPAR ddPTM_A459_Selumetinib_30min_R1 1 CDGDASPPSPAR 12 0 E7EUV9;F8W8D3;Q14493 E7EUV9 SLBP Histone RNA hairpin-binding protein 1 CDGDAS(0.956)PPS(0.044)PAR 110.8 0.0070659999999999985 2661400.0 1570.8 1728.5 1552.9 1834.0 1681.0 1547.5 1594.6 1632.5 887.82 1234.1 True False 1607.396583755266 1526.1264164421516 1342.0247094691151 1513.7263284437745 1528.953846804655 1531.9335550175795 1474.3180381801742 1589.2007968926634 1506.565696192769 1392.5087561519672 1.1543170386928954 1.0959546284358175 0.9637459754132113 1.087049773838965 1.0979850863054805 1.1001248992149222 1.0587495638119198 1.141250128497742 1.0819075208948665 1.0 10.443470683981293 -4.837836307216326 4.494812132438572 1.0717465404123452 1.155532215420986 0.22384382628740573 0.04876760600947918 0.30758001609639607 10.51322575331968 0.012384803171403197 0.06608872198108419 1.4526590456693621e-05 4.837836307216326 0.08378567500864076 CDGDAS(ph)PPSPAR ddPTM_A459_Selumetinib_30min_R2 2 CDGDASPPSPAR 12 0 E7EUV9;F8W8D3;Q14493 E7EUV9 SLBP Histone RNA hairpin-binding protein 1 CDGDAS(0.952)PPS(0.048)PAR;CDGDAS(0.865)PPS(0.135)PAR 82.774 0.035695 5630000.0 45285.0 43194.0 54759.0 58549.0 54467.0 35096.0 34239.0 41792.0 38605.0 43011.0 True False 42768.24099021819 46506.84090939955 51235.865557091245 50574.52519734148 47624.368518841904 39930.1554302324 35831.18134329141 41913.607800961974 46327.07871382457 41769.160674001294 1.0239190900677773 1.113425315686249 1.2266434070096695 1.2108101858225984 1.1401801652309742 0.9559721762636816 0.8578381936602834 1.0034582243126229 1.1091216094907146 1.0 15.350150533257912 -6.754082993623263 21.581576673546138 0.9775291648088378 1.1497676484306827 0.5061007341912032 0.07757001961429902 26.40313226957099 77458.35383781028 0.028069847362069116 0.02741704152617827 1.7616393651719532e-07 6.754082993623263 0.1722384836218449 CDGDASPPS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 CDGDASPPSPAR 12 0 E7EUV9;F8W8D3;Q14493 E7EUV9 SLBP Histone RNA hairpin-binding protein 1 CDGDASPPS(1)PAR;CDGDASPPS(1)PAR 157.09 0.00044141 49408000.0 8085.1 7841.700000000001 9511.0 9544.8 8092.599999999999 7940.700000000001 7902.5 7517.4 5024.700000000001 6592.2 True False 8273.467099134003 6923.590118492578 8219.458440183367 7877.979858086228 7360.625758864575 7860.823767578739 7306.408062660752 7318.014132043439 8526.548910432071 7438.373083465679 1.112268369211623 0.9307936077961212 1.1050075531239374 1.0590998555312754 0.9895478051814954 1.0567934250370017 0.9822588865435825 0.9838191832983237 1.14629218173867 1.0 12.860771395097503 CDILVQEELLAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 6 CDILVQEELLASPK 14 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK 212.69 1.0502e-06 68681000.0 22752.7 26755.400000000005 20487.2 19670.899999999998 17094.4 21299.0 23055.0 23271.0 18157.9 27856.5 True False 23282.79364095264 23622.865329752 17705.150768134223 16235.746583524895 15548.214538261442 21084.751397944707 21315.942788313005 22653.777485138835 30812.63009945559 31432.15312028787 0.7407317453516976 0.7515509751861266 0.563281513053792 0.5165330711323604 0.4946595442812937 0.6708020070166801 0.6781572584842952 0.7207198755505223 0.980290150074625 1.0 14.939953480498325 -8.158554754750547 1.812658247935296 1.0163683685766842 0.6208469164278723 0.7477282788461859 0.08219272289377114 0.19420311152599384 1.1418993539715663 0.0850416723749608 0.02605953862679738 6.941370811483727e-09 8.158554754750547 -0.39552145214881196 CDILVQEELLAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 CDILVQEELLASPK 14 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK;CDILVQEELLAS(1)PK 155.22 7.6887e-05 16398000.0 126750.0 93862.8 105457.0 103127.0 94421.1 83460.7 124377.0 111104.0 82929.5 88755.9 True False 119705.74242045183 101061.77494352902 98672.01143289986 89080.92469600205 82559.07728265607 94956.65384419881 130160.77694835 111427.2942457426 99517.71724383124 86193.28655147726 1.3888058711969395 1.1725016992265616 1.1447760652910006 1.033501891621225 0.9578365158793345 1.1016711120243432 1.5101034216929878 1.2927607091440332 1.1545878017355358 1.0 16.3952878841762 CDILVQEELLAS(ph)PKK ddPTM_A459_Selumetinib_30min_R1 1 CDILVQEELLASPKK 15 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 CDILVQEELLAS(1)PKK 72.64399999999998 0.023311 13557000.0 2067.4 2759.9 2367.9 2992.2 2046.9 2472.5 2434.4 2298.3 1432.5 2520.1 True False 2115.566397539874 2436.7696249572987 2046.3521859436635 2469.668440550416 1861.7582564095474 2447.6288948503816 2250.7712480533164 2237.3416180694694 2430.8478743395517 2843.579382852744 0.743980073247503 0.8569374358428058 0.7196395494648424 0.8685069442558654 0.6547235036363883 0.8607563093226763 0.7915274887790511 0.7868046981775895 0.8548549370550259 1.0 11.473492364545478 -8.734831967816891 1.555966893851212 1.0001218149804647 0.7852200900204911 0.510679920763035 0.0639914705902266 0.5925082551012979 2.6502244877668986 0.05619206570179042 0.016244785726783704 1.8414843494165683e-09 8.734831967816891 -0.21490172495997362 CDILVQEELLAS(ph)PKK ddPTM_A459_Selumetinib_30min_R2 1 CDILVQEELLASPKK 15 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 CDILVQEELLAS(1)PKK 58.082 0.047452 1906200.0 15909.0 15308.0 13981.0 16693.0 15833.0 13607.0 17684.0 15325.0 11836.0 16513.0 True False 15024.841468772911 16482.074377022 13081.477681361845 14419.384602968808 13843.91699118409 15481.240737952256 18506.34104018122 15369.593212809681 14203.530725471504 16036.226784073444 0.9369312164938325 1.0278025248053584 0.8157453656338821 0.8991756475587873 0.8632901727813759 0.965391731259851 1.1540333826259552 0.9584295245858061 0.8857152568818681 1.0 13.969047104866199 -6.9939410109686735 23.716074206715675 1.0051706420744826 0.910011976253611 0.22298412339876805 0.08026641752308168 130.32826236416247 510123.6614366049 0.02966525676624231 0.0260781647493722 1.0140491118995998e-07 6.9939410109686735 -0.09515866582087162 CDKAFHS(ph)SSSYHR ddPTM_A459_Selumetinib_30min_R1 1 CDKAFHSSSSYHR 13 1 K7EQV7;A0A087WVH9;Q9H0M5 K7EQV7 ZNF700 Zinc finger protein 700 1 CDKAFHS(0.978)S(0.019)S(0.003)SYHR 113.52 0.02155 23721000.0 2332.7 2673.9 2354.7 2077.6 3114.6 2068.6 2772.1 2842.6 908.01 1317.4 True False 2387.047371355937 2360.838544937616 2034.944673441255 1714.7861613821078 2832.8849799272907 2047.7917621385234 2562.9982651694872 2767.2050139338967 1540.826651573512 1486.501122562678 1.6058160569974864 1.5881848382782313 1.3689493015202565 1.153572059485481 1.905740222411331 1.3775918033672248 1.7241818564865692 1.8615559530579624 1.0365459051367407 1.0 10.537704837389647 -8.289026935658459 21.003630217895786 1.01826931890295 1.5624997387954431 0.5084386108842693 0.21805232895880147 98.09971085099637 74682.22020696953 0.21249744779059532 0.05500664287478779 5.140117707378868e-09 8.289026935658459 0.5442304198924932 CDNLCKS(ph)YTS(ph)CCHDFDELCLK ddPTM_A459_Selumetinib_30min_R2 1 CDNLCKSYTSCCHDFDELCLK 21 1 E5RIB9;E7EUF1;Q13822;Q13822-3;Q13822-2 E5RIB9 ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 2 CDNLCKS(0.419)Y(0.373)T(0.419)S(0.789)CCHDFDELCLK 64.2 0.044893 0.0 7325.4 4978.8 8224.6 7426.9 9241.3 6904.5 8924.7 8260.2 8506.1 6540.4 True False 6918.283593899626 5360.657950634776 7695.438190267403 6415.343407882887 8080.32527572978 7855.532202189412 9339.716233957555 8284.235814450272 10207.557680291753 6351.561658000001 1.0892256056722396 0.8439905395365014 1.2115820651090972 1.0100419004517653 1.2721793018497023 1.2367875217420128 1.470459823403253 1.304283302361712 1.6070941651703872 1.0 12.632895635485072 -6.375454035764465 1.1674264269676027 1.3676534459605176 1.0064868846065862 0.3794304546195306 0.17102535822771897 0.43795471688946414 1.24159064040508 0.06992455049028401 0.09187456524738813 4.2125586866834377e-07 6.375454035764465 -0.36116656135393144 CDPESVISQSHPS(ph)PSSEVTGPTFTENSVK ddPTM_A459_Selumetinib_30min_R2 1 CDPESVISQSHPSPSSEVTGPTFTENSVK 29 0 P24278 P24278 ZBTB25 Zinc finger and BTB domain-containing protein 25 1 CDPESVISQSHPS(0.678)PS(0.164)S(0.059)EVT(0.086)GPT(0.011)FTENSVK 93.529 4.0281e-07 2806800.0 3960.3 3367.6 5237.4 6138.2 6780.1 4262.9 4581.1 3521.8 4707.0 5238.3 True False 3740.202380337002 3625.88409145932 4900.431386049962 5302.166571014387 5928.323223136946 4850.075780246685 4794.1302272774365 3532.047854934626 5648.531524568637 5087.0566682620965 0.7352389847889735 0.7127666011823768 0.9633137009507914 1.042285729603594 1.1653739302971542 0.9534149305837453 0.9424173033470977 0.69432052467017 1.1103732261937547 1.0 12.312615450135548 -5.2767948323401015 6.612339503533161 0.9794998652410192 0.7230328864736925 0.4357328000745665 0.11826800246052095 0.14183008055237825 31.24299851080798 0.0326330848873863 0.07368878364776328 5.286949567423975e-06 5.2767948323401015 -0.2564669787673267 CDSLLHFTENLFPS(ph)PNKK ddPTM_A459_Selumetinib_30min_R1 2 CDSLLHFTENLFPSPNKK 18 1 E5RFE4;Q56NI9;E5RFP7;E5RIE3 E5RFE4 ESCO2 N-acetyltransferase ESCO2 1 CDSLLHFTENLFPS(1)PNKK;CDSLLHFTENLFPS(1)PNKK 93.851 0.0030642 27141000.0 7350.799999999999 7164.6 8955.5 10238.3 10141.9 8283.3 9669.599999999999 7372.700000000001 2797.0299999999997 6133.1 True False 7522.05933783308 6325.765301267821 7739.39228904028 8450.373101693516 9224.56693569787 8199.977522634648 8940.214286960374 7177.15204609528 4746.355623011487 6920.343126452982 1.0869488983978324 0.9140826091538164 1.1183538370310695 1.2210916348052168 1.332963809328616 1.184909096673295 1.2918744235074766 1.0371092755011881 0.6858555329241643 1.0 12.756627856419987 -8.02446933432071 7.51516673851964 0.8472601725169865 1.1627455699493188 0.49229047365066547 0.12981013902038419 0.18439094474368217 43.66145370078136 0.08943261829871674 0.03587453435680456 9.452151320425152e-09 8.02446933432071 0.3154853974323323 CEFQDAYVLLSEK ddPTM_A459_Selumetinib_30min_R1 1 CEFQDAYVLLSEK 13 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 134.61 0.016677 5226300.0 1614.9 2193.6 2038.6 2038.1 1996.2 1972.1 1792.4 1659.7 1432.8 2084.8 False True 1652.524027951603 1936.772292223026 1761.7693172282409 1682.184094875276 1815.6440624577344 1952.2624645235344 1657.197824930481 1615.6793645346106 2431.3569524284176 2352.404387671681 0.7024829730007465 0.8233160515994311 0.748922815507912 0.7150913778647713 0.7718248069817574 0.8299008770578805 0.704469789979737 0.6868204178677577 1.0335624968098622 1.0 11.199920371171642 -8.267772165715712 24.976423722706784 1.0167812998641403 0.7514004337342511 0.8376678547527411 0.0473339518705184 204.39818691073873 806131.5046927815 0.04265271066536291 0.012077416711142184 5.397937282635257e-09 8.267772165715712 -0.2653808661298892 CELLYEGPPDDEAAMGIK ddPTM_A459_Selumetinib_30min_R2 1 CELLYEGPPDDEAAMGIK 18 0 P13639 P13639 EEF2 Elongation factor 2 0 218.11 5.760199999999999e-39 0.0 12877.0 13159.0 14154.0 15245.0 14196.0 12549.0 13008.0 12947.0 11929.0 13855.0 False True 12161.347890715251 14168.2529871461 13243.347049709993 13168.604700908147 12412.571566149783 14277.510841520008 13612.897774862999 12984.673626508764 14315.133324108621 13454.97015038683 0.9038554344444691 1.053012591539548 0.9842717524965485 0.9787167532682747 0.9225268750070711 1.0611328514251317 1.0117374934846384 0.9650466319418372 1.063929028760949 1.0 13.715851569937913 -6.768482618195608 24.99999000195765 1.0176451221924137 0.9746195170013064 0.23548661554218586 0.045959622928453216 300.0707707034113 1065095.4262075718 0.0157799519413763 0.014207093659855936 1.704187524790546e-07 6.768482618195608 -0.04302560519110721 CENTPLIGRES(ph)PPPSYTSSMR ddPTM_A459_Selumetinib_30min_R1 1 CENTPLIGRESPPPSYTSSMR 21 1 Q9C0H2-3;Q9C0H2-2;Q9C0H2 Q9C0H2-3 TTYH3 Protein tweety homolog 3 1 CENTPLIGRES(0.999)PPPSYTSSMR 79.416 0.0012076 11350000.0 1365.5 894.43 1398.6 1215.0 1133.0 1163.7 1127.4 1576.2 1139.0 1257.3 True False 1397.3134931995248 789.7097197907738 1208.6778019598833 1002.8230583746932 1030.5203500473963 1151.9942345550605 1042.3593103250525 1534.3940557808357 1932.799810731412 1418.686702139103 0.9849345109759952 0.5566484260408203 0.8519695011854503 0.7068671729019744 0.7263903640554129 0.8120145433224106 0.7347353779755444 1.0815594827718258 1.3623866409807934 1.0 10.470340309455281 -7.854282188826564 4.157130355513285 1.1924495994865325 0.760126648956471 0.6365971091827717 0.13253199285447712 0.12025018468715196 3.778390213099862 0.07130079313132529 0.03256761469927391 1.3986782167998174e-08 7.854282188826564 -0.43232295053006153 CENTPLIGRES(ph)PPPSYTSSMR ddPTM_A459_Selumetinib_30min_R2 1 CENTPLIGRESPPPSYTSSMR 21 1 Q9C0H2-3;Q9C0H2-2;Q9C0H2 Q9C0H2-3 TTYH3 Protein tweety homolog 3 1 CENT(0.001)PLIGRES(0.999)PPPSYTSSMR 95.834 0.00022281 13961000.0 33266.0 15852.0 27488.0 30780.0 24867.0 18772.0 30683.0 24237.0 19618.0 19835.0 True False 31417.208894349104 17067.797427786303 25719.452006671483 26587.710901538383 21742.9851461994 21357.672604750478 32109.820297211067 24307.525657348662 23542.148172718807 19262.31201248088 1.6310196239159942 0.8860721089310225 1.3352214412271353 1.3802969697672356 1.128783768641645 1.1087803266249618 1.6669764396094162 1.261921499433649 1.2221870436666604 1.0 14.233493256601776 CEQDRPSPTTAPPAPPSPS(ph)PSPVPK ddPTM_A459_Selumetinib_30min_R2 1 CEQDRPSPTTAPPAPPSPSPSPVPK 25 1 P11279-2;P11279 P11279-2 LAMP1 Lysosome-associated membrane glycoprotein 1 1 CEQDRPSPTTAPPAPPS(0.046)PS(0.477)PS(0.477)PVPK 55.302 0.0072355000000000015 2763200.0 8180.1 9174.3 8977.7 9571.6 8371.2 8030.6 6967.4 7636.5 7130.4 7637.8 True False 7725.48278953481 9877.939309976015 8400.084556180685 8267.931568069034 7319.53501652247 9136.742255471401 7291.397905641182 7658.720950709365 8556.679240022131 7417.276868612378 1.0415524358038546 1.331747416868905 1.1325024945107882 1.1146855799675435 0.9868224074924962 1.2318189569187135 0.9830289518375838 1.0325515800979068 1.1536146474768054 1.0 12.856673906921953 -5.710765925580266 2.9678187295958876 1.070561703638917 1.1931743008255837 0.1767058678978961 0.09926303337018151 0.38254140672871817 6.830424319659797 0.027123707810453722 0.04956514969022452 1.9464088671522167e-06 5.710765925580266 0.12261259718666673 CGEEGHLS(ph)PYCR ddPTM_A459_Selumetinib_30min_R2 1 CGEEGHLSPYCR 12 0 Q9NUD5-2;Q9NUD5 Q9NUD5-2 ZCCHC3 Zinc finger CCHC domain-containing protein 3 1 CGEEGHLS(1)PYCR 86.37799999999999 0.019826 3512100.0 33862.0 33579.0 41069.0 45840.0 30247.0 38850.0 33391.0 30358.0 30191.0 43293.0 True False 31980.08560032615 36154.401326497355 38426.66525254625 39596.51292158932 26447.101448389163 44201.23485481333 34943.747663011265 30446.336753962558 36230.04360702182 42043.01860127728 0.7606515103878527 0.8599382853399344 0.9139844504737543 0.941809466563525 0.6290485870961152 1.0513335227901661 0.8311426920699186 0.7241710459162318 0.8617374492211446 1.0 15.35957863507105 -8.563776990764884 20.760849903892026 1.0000000042893509 0.8421688920092234 0.15501304137101557 0.11192038656600709 4261.279714498311 2163117.956320732 0.10530746555302999 0.027190270716256158 2.7303794665829795e-09 8.563776990764884 -0.15783111228012747 CGENTS(ph)PVLDAVLK ddPTM_A459_Selumetinib_30min_R2 1 CGENTSPVLDAVLK 14 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 CGENT(0.218)S(0.782)PVLDAVLK 134.25 0.0010227 0.0 18411.0 18942.0 19534.0 18333.0 17290.0 14080.0 14619.0 15338.0 12741.0 18617.0 True False 17387.790325072496 20394.79049187031 18277.203707011093 15836.013773811019 15117.875625438826 16019.392194485767 15298.81246699895 15382.631040657418 15289.556013284255 18079.47883722493 0.9617417892197049 1.1280629643968632 1.0109364253011017 0.8759109660398668 0.8361897907317837 0.8860538701758632 0.8461976478823771 0.8508337645765092 0.8456856611266728 1.0 14.142065470477998 -5.711230823519658 4.018572699470664 0.8675345458830153 1.0496952416328047 0.6000893123473791 0.058440905391114954 0.121523792749249 4.038059462863968 0.015131551257901657 0.026470044307225465 1.9443264153617754e-06 5.711230823519658 0.18216069574978944 CGERDELS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 CGERDELSPK 10 1 B8ZZS2;Q13506-2;Q13506;H0Y4C5 B8ZZS2 NAB1 NGFI-A-binding protein 1 1 CGERDELS(1)PK 74.69800000000002 0.033981 7694400.0 2147.6 2727.1 3205.2 2933.5 2267.1 2359.9 2170.9 2597.2 1373.8 2161.9 True False 2197.6349014978405 2407.809864205607 2769.951444903345 2421.219293614947 2062.0412052890133 2336.161548617762 2007.1472651983827 2528.313819105437 2331.238261617923 2439.400923689279 0.9008912311856476 0.98704966486776 1.1355047946420185 0.9925466823031147 0.8453063968551927 0.9576783897763798 0.8228033554086024 1.0364486602233833 0.9556601536791361 1.0 11.252311174031869 -4.751303380745326 24.277037835019147 0.9684150797214419 0.9008910292659889 0.05710629495642072 0.08432746830979661 1089.1993792693238 2608512.047852321 0.022273568567619605 0.28906229512403153 1.7729505359079564e-05 4.751303380745326 -0.06752405045545307 CGESGHLAR ddPTM_A459_Selumetinib_30min_R2 2 CGESGHLAR 9 0 P62633-2;P62633;P62633-7;P62633-3;P62633-5;P62633-6;P62633-8;P62633-4 P62633-2;P62633-8 CNBP Cellular nucleic acid-binding protein 0 ; 143.37 0.0028646 3362800.0 31935.0 22469.5 23117.0 36124.0 34894.0 25606.0 47183.0 60594.0 40067.0 60942.0 False True 30160.18054593394 24192.838399170098 21629.677387886524 31203.84888262417 30510.303763682045 29132.994071875186 49377.10299134082 60770.31850812331 48081.51956551761 59182.446113668244 0.5096136190114051 0.4087840227608088 0.36547454200091145 0.5272483807562258 0.5155296167563385 0.49225734968644513 0.834320076877274 1.026830124449492 0.8124287305254375 1.0 15.852881706414637 -7.316574980993276 3.025983078099599 0.9408381899353186 0.4618924441712271 0.9078597453786172 0.07065087504853251 0.07366687904296863 1.3411320070185104 0.03251203511577125 0.021275840880078136 4.824196830543944e-08 7.316574980993276 -0.47894574576409155 CGGVEQASSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 CGGVEQASSSPR 12 0 Q5VZL5-2;Q5VZL5-4;Q5VZL5;H7C1I7;Q5VZL5-3 Q5VZL5-2 ZMYM4 Zinc finger MYM-type protein 4 1 CGGVEQASS(0.002)S(0.998)PR;CGGVEQASS(0.002)S(0.998)PR;CGGVEQASS(0.003)S(0.997)PR;CGGVEQASS(0.003)S(0.997)PR 195.72 0.00010451 47911300.0 14204.099999999999 13741.2 15767.4 15010.900000000001 15256.3 14062.1 15467.599999999999 15961.7 9762.6 14982.399999999998 True False 14535.027893632638 12132.373915889424 13626.273684128613 12389.528104491099 13876.370358718528 13920.648041365228 14300.866478963793 15538.343865091343 16566.41916790736 16905.53698093447 0.8597791309453691 0.7176568203406927 0.8060243043149646 0.7328680608290418 0.8208180771996689 0.8234372003128025 0.8459279640210102 0.9191274954835801 0.9799404293747335 1.0 14.04520822171552 -7.787660057333698 0.9588647990281515 1.0060201361948968 0.7800049752625822 0.8129429206051427 0.038441005978415224 0.2106711460879566 0.35253033329077754 0.032257048613514916 0.01317940320982054 1.6305718583435368e-08 7.787660057333698 -0.22601516093231466 CGGVEQASSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 CGGVEQASSSPR 12 0 Q5VZL5-2;Q5VZL5-4;Q5VZL5;H7C1I7;Q5VZL5-3 Q5VZL5-2 ZMYM4 Zinc finger MYM-type protein 4 1 CGGVEQAS(0.001)S(0.097)S(0.902)PR;CGGVEQAS(0.002)S(0.099)S(0.899)PR;CGGVEQASS(0.005)S(0.995)PR;CGGVEQASS(0.007)S(0.992)PR 156.08 0.00043203 102816000.0 124927.0 101267.0 133669.0 155140.0 156392.0 117649.0 122794.0 137175.0 106527.0 124003.0 True False 117984.05746240469 109033.8532752732 125068.88206780308 134009.6643685723 136744.6387977809 133854.08183871146 128504.16431169485 137574.15653945622 127835.37661307023 120422.71119151311 0.9797492208489632 0.905425996445739 1.038582181303832 1.1128271655954607 1.1355386159701253 1.1115351955980952 1.0671090447991116 1.1424269988463096 1.0615553772889936 1.0 16.877747978108154 -5.4724429882451355 3.867874861137324 1.09726787520426 0.9440783945976371 0.6438708050501322 0.043110733955239386 0.1191433684931078 3.6266791053787446 0.010999112255357026 0.023498470062787925 3.3694344489259776e-06 5.4724429882451355 -0.15318948060662285 CGS(ph)PSDSSTTEEMEVAVSK ddPTM_A459_Selumetinib_30min_R1 2 CGSPSDSSTTEEMEVAVSK 19 0 P31751-2;P31751;M0R0P9;M0R275;M0QZK3;J3QLS6;C9JHS6;J3QKW1 P31751-2 AKT2 RAC-beta serine/threonine-protein kinase 1 CGS(0.759)PS(0.237)DS(0.004)STTEEMEVAVSK;CGS(0.966)PS(0.034)DSSTTEEMEVAVSK 268.26 1.4609e-58 11888500.0 3121.6000000000004 3656.8 4587.4 4912.4 3076.2 3944.1 3045.5 2941.8999999999996 2041.1000000000001 2593.9 True False 3194.327206423758 3228.6601559998 3964.456276784478 4054.541557168592 2797.9582531472206 3904.4259349562763 2815.7754830538843 2863.871255362036 3463.597623954247 2926.852331725621 1.091386528728779 1.1031168607321704 1.354511887672551 1.3852907825992389 0.9559615368424117 1.3340016825017937 0.962049042424273 0.9784816351406249 1.1833865297577792 1.0 11.515134244053675 -7.2747633603525195 24.9743636900069 1.0291861028429297 1.203258590439829 0.2760078244402071 0.1373005976945233 1118.0197067668669 2095597.9431432728 0.05817603808096544 0.039469688881023444 5.311737929230606e-08 7.2747633603525195 0.1740724875968993 CGS(ph)PSDSSTTEEMEVAVSK ddPTM_A459_Selumetinib_30min_R2 2 CGSPSDSSTTEEMEVAVSK 19 0 P31751-2;P31751;M0R0P9;M0R275;M0QZK3;J3QLS6;C9JHS6;J3QKW1 P31751-2 AKT2 RAC-beta serine/threonine-protein kinase 1 CGS(0.96)PS(0.04)DSSTTEEMEVAVSK;CGS(0.776)PS(0.224)DSSTTEEMEVAVSK 205.98 2.6757e-16 8875000.0 66230.0 61837.0 66135.0 67847.0 67736.0 55366.0 56628.0 58937.0 40101.0 60144.0 True False 62549.20173969644 66579.69906270634 61879.94610234354 58606.121557396866 59226.39811247685 62992.1639374928 59261.314206253264 59108.49691245441 48122.32051555702 58407.48644712125 1.0709106921819835 1.1399172111777782 1.0594523042583943 1.0034008501710727 1.0140206626781825 1.0784946891101408 1.014618464362527 1.0120020652826383 0.8239067188608463 1.0 15.833865679612149 -8.05328279416788 4.883711325112368 0.9104948407452782 1.0531623909500807 0.5143486397248418 0.05450839293375617 0.1675895836041916 8.50598707396921 0.03830806748128389 0.014300245884074714 8.845394476498913e-09 8.05328279416788 0.14266755020480248 CGSGPVHISGQHLVAVEEDAES(ph)EDEEEEDVK ddPTM_A459_Selumetinib_30min_R1 8 CGSGPVHISGQHLVAVEEDAESEDEEEEDVK 31 0 E5RI98;P06748-2;P06748;P06748-3 E5RI98;P06748-2 NPM1 Nucleophosmin 1 CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(0.999)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK 130.55 2.2012e-18 306341800.0 24876.62 28450.24 22647.239999999998 24686.019999999997 26887.02 25701.210000000006 30822.079999999998 24828.850000000002 12438.769999999999 22832.23 True False 25456.19684452375 25119.272674642263 19571.869200384634 20375.070020986688 24455.093788288916 25442.679162231594 28497.14569060103 24170.30824252888 21107.684198184004 25762.969125253712 0.9880925106404271 0.9750146635862527 0.759689968389538 0.7908665310247324 0.9492342931978762 0.9875678163698858 1.1061281621716181 0.9381802277920035 0.8193032447294111 1.0 14.653011249998697 -6.501958158342929 22.38700389212655 0.9741471892058929 0.8759872374696743 0.17969370457046374 0.09310335149529667 365.67922890074465 391311.4300659889 0.031681160271355945 0.035447956458815606 3.148051595298256e-07 6.501958158342929 -0.09815995173621861 CGSGPVHISGQHLVAVEEDAES(ph)EDEEEEDVK ddPTM_A459_Selumetinib_30min_R2 9 CGSGPVHISGQHLVAVEEDAESEDEEEEDVK 31 0 E5RI98;P06748-2;P06748;P06748-3 E5RI98;P06748-2 NPM1 Nucleophosmin 1 CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK;CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVK 147.54 4.2325e-20 453824500.0 609849.7 455641.6 711068.8 1245511.7 1211683.9 784688.6 614840.6 702377.5 835648.2999999999 981704.7 True False 575956.6950957777 490587.8456013382 665319.4075611713 1075870.8578324774 1059461.3358904966 892772.3319561046 643431.9061835367 704421.302240146 1002801.3099643509 953360.334535868 0.604133268640944 0.5145880605995371 0.6978677247832784 1.128503902311241 1.1112916045602867 0.9364479511209579 0.6749094574999114 0.7388825365627205 1.0518596942178768 1.0 19.862662076392716 -5.560930511973875 6.6701516056566215 0.9325208689074406 0.5698168552483721 0.5665193622342843 0.14051483353963415 0.14718779688453604 18.281699517006057 0.0431126479930139 0.07621905717376765 2.7483338570943454e-06 5.560930511973875 -0.36270401365906846 CGSGPVHISGQHLVAVEEDAES(ph)EDEEEEDVKLLSISGK ddPTM_A459_Selumetinib_30min_R1 1 CGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGK 38 1 E5RI98;P06748-2;P06748;P06748-3 E5RI98;P06748-2 NPM1 Nucleophosmin 1 CGSGPVHISGQHLVAVEEDAES(1)EDEEEEDVKLLSISGK 95.152 2.7448000000000003e-14 64853000.0 1462.1 1263.3 3024.5 3544.6 3226.3 2004.7 1775.8 1770.7 1082.5 954.51 True False 1496.1640852486466 1115.3922487077637 2613.7895123892968 2925.6021503826632 2934.481734649528 1984.534538121965 1641.8499762952183 1723.7352839557975 1836.9234373281438 1077.0306562147432 1.3891564521542594 1.0356179206893177 2.4268478314029975 2.7163592173548525 2.724603722017396 1.8425980046813817 1.5244226956970284 1.6004514579129225 1.7055442449373417 1.0 10.072843599483425 -7.121153517271599 4.222140641720532 1.5107351671506377 2.0757028186107203 0.2162495116265315 0.5316940877690147 0.45561694015427484 13.496176760017507 0.2384690261517894 0.18310028900216319 7.565654120270577e-08 7.121153517271599 0.5649676514600825 CGT(ph)LRLDLT(ph)GT(ph)S(ph)GT(ph)AVPAR ddPTM_A459_Selumetinib_30min_R2 1 CGTLRLDLTGTSGTAVPAR 19 1 A0A6I8PIW1;O43301;A0A6I8PIT5;A0A6I8PLB1;A0A1B0GTF3;A0A6I8PL32 A0A6I8PIW1 HSPA12A Heat shock 70 kDa protein 12A 5 CGT(1)LRLDLT(1)GT(1)S(1)GT(1)AVPAR 46.985 0.033988 3228700.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CIACQAAKLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 CIACQAAKLSPR 12 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 CIACQAAKLS(1)PR 128.21 0.011786 31770000.0 2078.1 1365.5 2801.9 2719.1 2458.9 1894.6 1635.8 1917.7 1346.9 1496.0 True False 2126.5156867212977 1205.626625196272 2421.41736973502 2244.260228828499 2236.4929291540557 1875.5420441591643 1512.4102890098643 1866.8363664325022 2285.5909263161907 1688.026172274 1.2597646420710367 0.7142227087463517 1.4344667218477087 1.329517436216748 1.324916026711361 1.1110858794520675 0.8959637675359279 1.105928567397519 1.3540020669449633 1.0 10.721121557378506 -6.977410568004758 24.16490237146197 1.084332919220615 1.2051436185139002 0.07439468784854075 0.2102790902010137 503.1957075191758 538287.5467807603 0.07745744924581202 0.06830538952718111 1.0533905840200283e-07 6.977410568004758 0.12081069929328514 CIACQAAKLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 CIACQAAKLSPR 12 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 CIACQAAKLS(1)PR 85.287 0.017304 50880000.0 53513.0 63790.0 67276.0 67787.0 56933.0 37668.0 39027.0 36746.0 33674.0 62009.0 True False 50538.9616895119 68682.48788282156 62947.53540457039 58554.293660902586 49780.56755252223 42856.42508394104 40841.8328305334 36852.92477637222 40409.740930173 60218.63905126935 0.8392577860566345 1.1405519780071118 1.045316473375921 0.9723616239657997 0.8266637761464473 0.7116803992772678 0.6782257698610759 0.6119853480082161 0.6710503851767339 1.0 15.877922482893153 -6.398568457119621 2.0874578756120963 0.7058810093931464 1.0208008040705012 0.5104473257334641 0.12078622242966637 0.2269197883796768 1.9499757856620945 0.041000711662982546 0.048178259214082246 3.9942159618144735e-07 6.398568457119621 0.31491979467735487 CIFMSETQS(ph)SPTK ddPTM_A459_Selumetinib_30min_R1 2 CIFMSETQSSPTK 13 0 B4DGW0;A0A087WUY7;O75928-2;O75928 B4DGW0 PIAS2 E3 SUMO-protein ligase PIAS2 1 CIFMSET(0.001)QS(0.926)S(0.073)PTK;CIFMSET(0.001)QS(0.788)S(0.211)PTK 212.1 4.9679e-06 28356000.0 5530.5 6630.1 5435.4 5344.6 5523.2 5516.6 6847.700000000001 6382.5 3398.1000000000004 5780.9 True False 5659.349889520304 5853.844809750136 4697.302534515053 4411.265940567393 5023.627535200158 5461.108012672039 6331.1724758851005 6213.215366718176 5766.327512595623 6522.93482573447 0.8676079158713764 0.8974250036433569 0.720121028341893 0.676270123559098 0.7701483564393128 0.8372164000668408 0.970601829548745 0.952518388226971 0.8840081445925448 1.0 12.6713054984877 -7.094897396240733 3.5790124184628356 0.9473942288773652 0.7836298114609452 0.5839933780193196 0.06586581291049436 0.2033940411076264 4.8398471342795935 0.029622090497212664 0.02281486577243078 8.03715980781479e-08 7.094897396240733 -0.16376441741642 CIFMSETQS(ph)SPTK ddPTM_A459_Selumetinib_30min_R2 3 CIFMSETQSSPTK 13 0 B4DGW0;A0A087WUY7;O75928-2;O75928 B4DGW0 PIAS2 E3 SUMO-protein ligase PIAS2 1 CIFMSETQS(0.999)S(0.001)PTK;CIFMSETQS(0.495)S(0.495)PT(0.01)K;CIFMSETQS(0.891)S(0.109)PTK 265.77 1.3134999999999998e-30 19591900.0 152593.0 126511.0 137860.0 154745.0 153361.0 133356.0 151849.0 164557.0 126077.0 138916.0 True False 144112.49193817738 136213.9869030201 128990.2376906189 133668.46404998578 134094.4201152645 151724.5785147615 158910.27938308532 165035.833626122 151295.92288571075 134905.13413288613 1.0682506108049357 1.0097020234147998 0.9561551420538165 0.9908330391511846 0.9939904880356664 1.124676088052421 1.177940931636844 1.223347315036625 1.1214986283374444 1.0 17.041585728928382 -6.814480117495487 4.639886493541408 1.1491518324713177 1.0003427975868906 0.5111233096310486 0.06024455229828546 0.14615231349902646 6.541584116617585 0.021083501361966846 0.0189408670352483 1.5329213836733637e-07 6.814480117495487 -0.1488090348844271 CIFMSETQSS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 CIFMSETQSSPTK 13 0 B4DGW0;A0A087WUY7;O75928-2;O75928 B4DGW0 PIAS2 E3 SUMO-protein ligase PIAS2 1 CIFMSETQS(0.317)S(0.682)PTK;CIFMSETQS(0.24)S(0.76)PTK 136.38 0.0010972999999999998 16256700.0 126386.0 84468.0 104700.0 113906.0 116686.0 91656.0 124345.0 125807.0 95476.0 99788.0 True False 119361.97208324433 90946.42399257213 97963.71598874095 98391.80630119014 102026.86149392457 104280.78202967245 130127.28888494309 126173.0775415301 114573.86782233167 96906.86115963898 1.231718483654259 0.9384931356176324 1.0109058823746335 1.015323426264988 1.0528342397330483 1.0760928667154546 1.3428077984135574 1.302003553016536 1.1823091414919429 1.0 16.564311193905603 -7.103550287437283 6.322727971797502 1.2313044942759201 1.0418976589322864 0.30539088755964083 0.11042546461574239 0.24278471910962038 12.62448962523126 0.04088284260668178 0.03165814610806352 7.878611988518879e-08 7.103550287437283 -0.18940683534363378 CIQVEITPTSS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 CIQVEITPTSSR 12 0 H7C0W7;Q9BYI3-3;Q9BYI3 H7C0W7 FAM126A Hyccin 1 CIQVEIT(0.003)PT(0.016)S(0.05)S(0.931)R 91.712 0.024113 0.0 1101.9 1537.8 1533.8 1915.0 1582.6 1513.6 1592.6 1565.8 828.36 1098.4 True False 1127.5721260758387 1357.7536610961747 1325.5183845603242 1580.5811990020873 1439.4541094307237 1498.3745582388417 1472.4688997903836 1524.269897564798 1405.6664189793453 1239.3903393220326 0.9097796636793536 1.0955012460714264 1.0694922676946192 1.2752892683242083 1.1614211146894444 1.2089609792008529 1.1880590424771658 1.2298545899579945 1.134159573769365 1.0 10.275414912750607 -4.510954815754339 1.1546603363201182 1.178895843191489 0.6433773263611502 0.5004578581414454 0.07475311755789892 1.986321879977223 1.4823426423481199 0.021306088315827053 1.4928011661695488 3.0835087435701215e-05 4.510954815754339 -0.5355185168303389 CIS(ph)PEGVNGNR ddPTM_A459_Selumetinib_30min_R2 1 CISPEGVNGNR 11 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 CIS(1)PEGVNGNR 163.71 0.00064187 4429100.0 12223.0 16069.0 16716.0 16248.0 17715.0 13732.0 10057.0 8998.5 12503.0 14390.0 True False 11543.69459254582 17301.440630021323 15640.510759004688 14034.994370636628 15489.483325890636 15623.458353315225 10524.670427567433 9024.684145218129 15003.949363008633 13974.523310289886 0.8260528345926356 1.238070182850654 1.119216048499349 1.0043272359996864 1.108408707900987 1.1179957989558882 0.753132696828219 0.6457954911830851 1.0736644842805299 1.0 13.770511451196793 -7.2547488182403805 24.902981839718286 0.8386311240459378 1.0778288515791374 0.29263683524202555 0.14983608377965224 533.0952072414148 1984241.974633496 0.05637944485121795 0.04265350262624595 5.5622586715198326e-08 7.2547488182403805 0.23919772753319968 CKQIAQS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 CKQIAQSK 8 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;H7C1M2;H7C2G8;J3QSZ5 P18583-10 SON Protein SON 1 CKQIAQS(1)K 65.252 0.046944 8706500.0 37664.0 37836.0 43138.0 44295.0 45864.0 33395.0 31777.0 36666.0 25706.0 47063.0 True False 35570.78566093804 40737.89953808495 40362.54804510312 38261.94458686297 40102.154290637736 37994.85812037301 33254.69346493094 36772.69198961694 30847.918285651464 45704.168905640945 0.7782831744381153 0.8913388102995777 0.8831261788926535 0.8371653068641747 0.8774288046552403 0.8313214971442915 0.7276074428480975 0.8045806951557617 0.6749475819008739 1.0 15.480038146259082 -7.01240508451697 22.145984411281045 0.7846368897168928 0.8561203962284891 0.062482396158861975 0.08420495975392227 256.59710769493677 458086.3371443744 0.028922261292582335 0.023634903116790052 9.718403250209096e-08 7.01240508451697 0.0714835065115963 CLDSNEQLERLNLSGNQICS(ph)FK ddPTM_A459_Selumetinib_30min_R2 2 CLDSNEQLERLNLSGNQICSFK 22 1 A0A2R8Y4H4;Q6ZRR7-2;Q6ZRR7 A0A2R8Y4H4 LRRC9 Leucine-rich repeat-containing protein 9 1 CLDSNEQLERLNLS(0.111)GNQICS(0.889)FK;CLDSNEQLERLNLS(0.056)GNQICS(0.944)FK 52.185 0.022083 52508000.0 449280.0 389270.0 428170.0 449250.0 403210.0 290900.0 266300.0 257440.0 193548.0 356530.0 True False 424310.81621033966 419125.75729966996 400622.0083562477 388061.375000524 352555.1550568645 330968.83447272104 278683.477663439 258189.1077785139 232263.00818296414 346236.0525238125 1.2254957654392664 1.2105202628222675 1.1570776799123041 1.1208000211758276 1.0182508507909278 0.9559051752704422 0.804894451724586 0.7457025514717501 0.6708227132614683 1.0 18.401396430479473 -6.66815509273076 1.037671377487524 0.7752515506917116 1.204720997220858 0.8021365333122513 0.08285836016551591 0.20269868500340765 0.4690349304809597 0.04302312205537041 0.042936789659873485 2.14706359028852e-07 6.66815509273076 0.4294694465291463 CLELFSELAEDKENYKK ddPTM_A459_Selumetinib_30min_R1 1 CLELFSELAEDKENYKK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 65.956 0.0268 11143000.0 1092.8 906.93 1258.8 1418.0 871.05 1196.2 1092.6 1077.4 552.9 1095.3 False True 1118.2601137813558 800.7462139796818 1087.8618740934512 1170.3729191566376 792.2636812963681 1184.1673140627004 1010.1843023426933 1048.8238521115813 938.2309177817365 1235.892424125475 0.9048199438334154 0.6479093150411491 0.8802237580372166 0.9469860776796983 0.641045827153588 0.9581475628031497 0.8173723558969996 0.8486368486753494 0.759152576281576 1.0 10.271337456759547 -11.036323485305456 3.0394191364135765 1.0058807974296098 0.8221530747247048 0.2014516888143678 0.10589514967941058 81728714.84920457 94879287.54405938 4004052.013677743 0.024578134460928564 9.19764227913482e-12 11.036323485305456 -0.183727722704905 CLLADLPLPPELPGGDDLS(ph)KSPEEK ddPTM_A459_Selumetinib_30min_R1 1 CLLADLPLPPELPGGDDLSKSPEEK 25 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28;Q9BVE2;A0A087X209 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 CLLADLPLPPELPGGDDLS(0.5)KS(0.5)PEEK 75.661 0.00016545 16108000.0 1094.1 1296.2 1321.1 992.25 811.43 1142.2 959.65 1037.6 826.68 1122.8 True False 1119.5904012519957 1144.4403014129678 1141.7018762828563 818.9721643393328 738.0362997696018 1130.7105050346233 887.2628278813528 1010.079477400201 1402.8155816816902 1266.922316998159 0.8837088006348716 0.9033231841117144 0.9011617057847718 0.6464265040967961 0.5825426625353812 0.8924860584299474 0.7003293066804838 0.7972702539438089 1.107262507622027 1.0 10.30711235111603 -8.252036687062986 23.15150925438274 1.053631252041487 0.7849337975466283 0.47952444877431954 0.11047992668510562 195.0890082549352 480360.4370390501 0.08291885321368804 0.030276759635167058 5.597103179216849e-09 8.252036687062986 -0.2686974544948587 CLNNVIES(ph)PGLNVMR ddPTM_A459_Selumetinib_30min_R2 1 CLNNVIESPGLNVMR 15 0 Q9HCM4-4;Q9HCM4-3;Q9HCM4 Q9HCM4-4 EPB41L5 Band 4.1-like protein 5 1 CLNNVIES(1)PGLNVMR 172.26 6.4279e-09 0.0 11042.0 9283.4 9161.7 10798.0 8445.9 6283.5 12187.0 9308.7 8057.3 7641.2 True False 10428.329844628226 9995.40692916423 8572.246196504737 9327.293772411022 7384.850534696005 7148.995089066145 12753.719648082362 9335.786775861758 9668.985139772016 7420.578701778121 1.4053256846570992 1.3469848283893449 1.1551991483427906 1.2569496460129197 0.9951852586546174 0.9634012893567317 1.7186960964414153 1.2580941663787912 1.3029961042600533 1.0 12.857315986013516 -5.092210474018819 4.7638949603223315 1.2198064925957346 1.393478014788418 0.09720678216917789 0.20680714285204743 0.5540269257826793 20.521186978749828 0.055199825814352566 0.16390637307446532 8.087038785237548e-06 5.092210474018819 0.17367152219268345 CLSSLKDER ddPTM_A459_Selumetinib_30min_R2 1 CLSSLKDER 9 1 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 114.89 0.0235 24376000.0 168410.0 140290.0 165050.0 200540.0 181660.0 139250.0 141350.0 183140.0 120550.0 163900.0 False True 159050.4463986453 151049.79189655185 154430.8626928522 173226.10604920442 158838.24673899487 158430.4235143567 147923.05507971128 183672.90707954078 144663.3684484276 159167.78113665793 0.9992628235615605 0.9489972833563838 0.9702394642309005 1.0883239359885046 0.9979296413174213 0.9953674191030648 0.9293530011121273 1.1539578284492342 0.9088734379241162 1.0 17.280188808443313 -5.6101252613413655 22.50575937822175 1.0137152423619173 0.97035881113606 0.059976331082416845 0.06738639884252604 26.006477708076602 6697.396812689688 0.017366722000229692 0.030080067785854394 2.4540010186104615e-06 5.6101252613413655 -0.043356431225857306 CLVAGLLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 CLVAGLLSPR 10 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 CLVAGLLS(1)PR 119.22 0.0054670000000000005 11582000.0 2234.7 3009.9 3184.6 3752.5 2950.1 2994.3 2526.7 2480.9 1628.6 2389.6 True False 2286.7641620307427 2657.4995087354514 2752.1488117556473 3097.1963181490005 2683.263975882459 2964.1800606068737 2336.1089847421604 2415.098472901078 2763.6152517622295 2696.3284366750986 0.8481029725186601 0.9855993329998299 1.0207023648607816 1.1486717552733379 0.9951547220231265 1.0993393906649105 0.8664037188373339 0.8956989215598633 1.024954977358064 1.0 11.396780524914297 -7.264641529248381 24.99965449076076 0.9380726524642437 1.0201290802527219 0.13377331694288308 0.08516004704294743 539.8953105373487 4215012.398171604 0.03577376400098355 0.025218954828721975 5.436989205368035e-08 7.264641529248381 0.08205642778847821 CLVAGLLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 CLVAGLLSPR 10 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 CLVAGLLS(1)PR;CLVAGLLS(1)PR 118.03 0.005838 16306100.0 39419.0 33023.0 36989.0 44735.0 51529.0 37440.0 37637.0 48646.0 30799.0 33663.0 True False 37228.249786759676 35555.75791431915 34609.16801057816 38642.01582782062 45055.46634489518 42597.02015351895 39387.19507630066 48787.551806221185 36959.66059596122 32691.06172302215 1.1387898656268567 1.0876293408751414 1.0586737226159044 1.182036122143063 1.378219732556609 1.3030173358829973 1.2048307090791996 1.4923819917376175 1.1305738831337184 1.0 14.996608612502442 -6.00264873752214 5.8631844160011015 1.277069457855844 1.0971456194355975 0.2161135422813233 0.12809437678184232 0.1913705050568293 25.654112289307307 0.03489555304075424 0.049246562718247136 9.939196172694465e-07 6.00264873752214 -0.1799238384202464 CMKQRDMNEVLAMKMHY(ph)IS(ph)CIFQK ddPTM_A459_Selumetinib_30min_R2 1 CMKQRDMNEVLAMKMHYISCIFQK 24 3 G3V0G5;Q8IV38 G3V0G5 ANKMY2 Ankyrin repeat and MYND domain-containing protein 2 2 CMKQRDMNEVLAMKMHY(1)IS(1)CIFQK 41.71100000000001 0.030523 3486500.0 6868.6 8289.2 8262.8 7937.8 11089.0 5614.0 4758.1 4802.4 3171.5 9326.1 True False 6486.870709184336 8924.954986021086 7731.180443856419 6856.657946531233 9695.900683082195 6387.27754118204 4979.361077996286 4816.374188919883 3805.8886191139622 9056.83126088218 0.7162406499944532 0.9854390270656044 0.8536297322054075 0.7570702985431752 1.0705621429605574 0.7052441805744638 0.5497906425068222 0.5317946255355921 0.42022297970286465 1.0 13.144790663427644 -6.992456006956249 23.805663492381314 0.5923038370360452 0.8760386218628295 0.32298386813341184 0.17067383519253154 101.08354039153546 318973.53220525634 0.057029657420874236 0.05017812392352299 1.0175224336697004e-07 6.992456006956249 0.2837347848267844 CMVEVPQELETS(ph)TGHSLEK ddPTM_A459_Selumetinib_30min_R2 2 CMVEVPQELETSTGHSLEK 19 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 CMVEVPQELET(0.128)S(0.82)T(0.041)GHS(0.011)LEK;CMVEVPQELET(0.102)S(0.877)T(0.02)GHS(0.001)LEK 125.35 0.00025849 10921000.0 82527.0 67146.0 84980.0 103543.0 92618.0 74387.0 89778.0 85466.0 70410.0 87478.0 True False 77940.47972175643 72295.88229158083 79512.47931922818 89440.26477836198 80982.49882457445 84633.13403204626 93952.85489173197 85714.69191034201 84493.96741977408 84952.28284486028 0.9174618634332783 0.8510175344388031 0.9359663643699103 1.0528294447566247 0.9532704256160432 0.9962431990980531 1.1059485601264951 1.008974556538687 0.9946050252007569 1.0 16.374365095701826 -5.569928794968374 4.685992404924943 1.0162675697775005 0.8854342694198898 0.6339421257625608 0.04106086432392057 0.11973364099359544 5.756327610652343 0.011571867986639953 0.021233023038872964 2.691976132428195e-06 5.569928794968374 -0.13083330035761076 CNELKSPGS(ph)PPGPELPIETALDDR ddPTM_A459_Selumetinib_30min_R1 1 CNELKSPGSPPGPELPIETALDDR 24 1 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 CNELKS(0.101)PGS(0.899)PPGPELPIETALDDR 70.21300000000001 0.019325 0.0 650.6 427.14 1186.6 1085.2 591.2 658.22 781.79 743.5 541.02 513.99 True False 665.7577141527729 377.1302502280015 1025.4662375272396 895.6901917269278 537.7260643848377 651.5989044159422 722.8189508772599 723.7799647716358 918.0714254626067 579.9656231865731 1.1479261658558697 0.6502631106924761 1.7681500360192044 1.5443849702774315 0.9271688577511653 1.1235129779516688 1.2463134399342344 1.2479704586538884 1.5829755915847896 1.0 9.179823578414805 -8.012783166787678 22.85461883671063 1.3328161119743276 1.2046757356688278 0.009731144714748785 0.316571794736202 966.5055668147328 1727957.8005009787 0.20119501496659015 0.08420469274061472 9.709946414583116e-09 8.012783166787678 -0.1281403763054998 CPARLS(ph)DSENEEPSR ddPTM_A459_Selumetinib_30min_R1 1 CPARLSDSENEEPSR 15 1 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 CPARLS(0.999)DS(0.001)ENEEPSR 158.14 0.00070603 4608000.0 841.07 612.66 714.5 676.07 863.86 737.45 663.23 643.52 445.77 728.29 True False 860.6652945626696 540.9294823820934 617.4748244675653 558.0070659056611 785.7240155268705 730.0319225510265 613.2020271304633 626.4517591524449 756.4391322473587 821.7731156453417 1.0473271492786493 0.6582467497215448 0.7513933136917723 0.6790281347515925 0.9561325389792513 0.8883618953361957 0.7461938282672016 0.7623171739568163 0.9204963241628122 1.0 9.682596323201226 -6.260807260566926 24.999656207797766 0.8608689059478494 0.7726875839879994 0.11104420363508549 0.12383693929996076 141.5353664201332 5597589.8559883535 0.037300666960776455 0.04533355304105717 5.485203436613078e-07 6.260807260566926 -0.08818132195984996 CPEALFQPSFLGMESCGIHET(ph)TFNSIMK ddPTM_A459_Selumetinib_30min_R1 1 CPEALFQPSFLGMESCGIHETTFNSIMK 28 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 CPEALFQPS(0.009)FLGMES(0.355)CGIHET(0.487)T(0.149)FNS(0.001)IMK 74.123 0.00015052 22297000.0 877.82 1156.5 1149.7 1062.9 1764.4 1138.2 1579.2 1217.7 403.2 940.17 True False 898.2714980596172 1021.0964423577368 993.5770548500485 877.2844681040833 1604.8103315301219 1126.750741402913 1460.0796725787861 1185.4026403529529 684.2009514371429 1060.8499775313144 0.8467469643068375 0.962526713469809 0.9365858282451818 0.8269637429277199 1.512758981495808 1.0621207194866094 1.3763300216836618 1.117408366366263 0.6449554281269205 1.0 10.051004933398449 CPFPAGAALACCS(ph)EDEEDDEEHEGGGSR ddPTM_A459_Selumetinib_30min_R1 1 CPFPAGAALACCSEDEEDDEEHEGGGSR 28 0 Q147X3 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 CPFPAGAALACCS(1)EDEEDDEEHEGGGSR 140.88 6.8982e-13 5442700.0 2557.5 2540.7 3126.9 2758.6 2634.4 3163.2 3069.9 2787.5 1598.6 2228.9 True False 2617.084773971282 2243.2336628606145 2702.2841548322335 2276.8622953353315 2396.1189851410977 3131.381079955804 2838.334971409332 2713.5664449239207 2712.7074428755386 2515.0010263245426 1.0405899427388807 0.8919414502740411 1.074466422298598 0.9053126704535662 0.9527308180238874 1.2450814322457944 1.1285621523412712 1.078952420504402 1.0786108691334917 1.0 11.29634327342968 -6.722506595895791 24.99983506145615 1.1125711435429992 0.9703801284938763 0.4270175042438138 0.07696219774563476 144.48054738887876 92774.6541477689 0.024683390821255993 0.024682968651361197 1.8944947412883127e-07 6.722506595895791 -0.1421910150491229 CPFPAGAALACCS(ph)EDEEDDEEHEGGGSR ddPTM_A459_Selumetinib_30min_R2 2 CPFPAGAALACCSEDEEDDEEHEGGGSR 28 0 Q147X3 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 CPFPAGAALACCS(1)EDEEDDEEHEGGGSR;CPFPAGAALACCS(1)EDEEDDEEHEGGGSR 166.24 7.1986e-22 7673500.0 25702.0 21527.0 27980.0 31490.0 30261.0 20775.2 22298.3 27510.0 19747.3 24251.0 True False 24273.58573325799 23178.05167978525 26179.797262320597 27201.007676720044 26459.34264322757 23636.7952215114 23335.215133243222 27590.049545474343 23697.31178566266 23550.81061833495 1.0306900312960074 0.984172139779363 1.1116304099502592 1.1549924169295183 1.123500293557974 1.0036510252054556 0.990845517439477 1.1715116728931079 1.0062206422403845 1.0 14.523489097770735 -9.782879513617758 15.353419564101289 0.9999998200110811 1.0668219389302882 0.07397763195448159 0.0674731136966112 0.0 0.0 0.0679394250797452 0.01647773092632512 1.6486197048944817e-10 9.782879513617758 0.06682211891920709 CPGNITEESHDSVY(ph)S(ph)S(ph)VT(ph)QNR ddPTM_A459_Selumetinib_30min_R1 1 CPGNITEESHDSVYSSVTQNR 21 0 Q9P2P6 Q9P2P6 STARD9 StAR-related lipid transfer protein 9 4 CPGNIT(0.001)EES(0.001)HDS(0.038)VY(0.964)S(0.998)S(0.999)VT(0.999)QNR 55.469 0.03038 29170000.0 583.04 822.51 794.95 717.2 709.14 694.41 496.39 493.83 231.24 520.85 True False 596.6236976016487 726.2101468254752 687.0001563477831 591.9544835113823 644.998412208836 687.424865873833 458.94690265411845 480.7320242140912 392.3973908986232 587.7061710086313 1.0151734438617737 1.2356687451131254 1.168951748743325 1.00722863347761 1.097484498251701 1.169674404973599 0.7809121722619757 0.8179802219688298 0.667676145420056 1.0 9.198951236709188 -7.264889427280383 24.991831924317122 0.8014738031207692 1.1178126424551298 0.6803903972016523 0.10019056452801225 165.79788467927227 1201017.096592585 0.039639769496466915 0.027950280976715248 5.4338866231765127e-08 7.264889427280383 0.3163388393343606 CPLPCIPTLIGT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 CPLPCIPTLIGTPVK 15 0 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 CPLPCIPTLIGT(1)PVK 139.49 0.00091987 8423400.0 2317.7 2267.8 1583.7 1397.6 2021.3 1848.4 2034.4 2204.1 1154.1 2308.5 True False 2371.697900540858 2002.284921728383 1368.642238641404 1153.5353962012098 1838.4737718894985 1829.806774212919 1880.9435700951628 2145.6401080741916 1958.423407871049 2604.8184616942012 0.9105041043813398 0.768685016316291 0.5254271108594741 0.4428467523417883 0.7057972749063426 0.7024699805846714 0.7221015966202027 0.8237196332978401 0.7518464095180245 1.0 11.346967114540234 -8.584090082240754 0.6775699385697738 0.9951774410430585 0.6622581838164999 0.3669966812074762 0.12368344084092059 0.9836957682195617 1.019384477528067 0.13690380722662077 0.05433966938717002 2.6056130324124277e-09 8.584090082240754 -0.3329192572265586 CPLPCIPTLIGT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 CPLPCIPTLIGTPVK 15 0 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 CPLPCIPT(0.002)LIGT(0.998)PVK;CPLPCIPTLIGT(1)PVK 171.15 0.00011166 20965300.0 136028.0 89378.0 95305.0 126119.0 122737.0 115609.0 144141.0 143033.0 113207.0 95130.0 True False 128468.10832322852 96233.00520443394 89173.18006023826 108941.37463258993 107317.68077729826 131533.09035598743 150843.84210997305 143449.20234961217 135851.56326786536 92383.3497225766 1.3905980754000906 1.0416704470385376 0.9652516425094094 1.1792317009475883 1.1616560895396069 1.4237748550033733 1.6328033413266665 1.5527603489198456 1.470519998201213 1.0 16.49534523728149 -6.768205592507678 4.050907771133151 1.4689374379533495 1.129428382764291 0.31751137307836785 0.1895534409506045 0.20846885246615163 7.6998169438091 0.06534869708580884 0.06074810104137051 1.7052749305595557e-07 6.768205592507678 -0.3395090551890585 CPQDQS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 1 CPQDQSPDR 9 0 Q9H116 Q9H116 GZF1 GDNF-inducible zinc finger protein 1 1 CPQDQS(1)PDR 82.505 0.04117 2016300.0 4421.0 2992.7 5171.7 6449.7 6079.2 6568.8 10132.0 15589.0 10212.0 8574.6 True False 4175.298518665224 3222.2304669528157 4838.958452521209 5571.239733646917 5315.476547262452 7473.5925743705975 10603.158076177122 15634.361409102114 12254.68534712023 8327.029018513673 0.5014151517164391 0.3869603984552903 0.5811146378573491 0.6690549199792931 0.6383401013067725 0.8975100912647703 1.2733422752103878 1.8775437643296167 1.4716755904025445 1.0 13.02358613621914 -7.126251233996987 1.8413566859121573 1.5130848913084525 0.543435191143411 0.7752633943754484 0.21561029941364984 0.15063913068773302 1.0078048331463036 0.10420216095242617 0.07250029576201138 7.477368188528424e-08 7.126251233996987 -0.9696497001650415 CPQDQS(ph)PDRVGTEMEQVSK ddPTM_A459_Selumetinib_30min_R2 2 CPQDQSPDRVGTEMEQVSK 19 1 Q9H116 Q9H116 GZF1 GDNF-inducible zinc finger protein 1 1 CPQDQS(1)PDRVGTEMEQVSK;CPQDQS(1)PDRVGTEMEQVSK 65.21300000000001 0.013391 26955000.0 65069.0 55968.0 72309.0 67120.0 72601.0 57460.0 60420.0 65947.0 49677.0 63023.0 True False 61452.725471845166 60260.565634515755 67656.71766408648 57978.14021154177 63480.21331882503 65374.593430053406 63229.64971995872 66138.89485188645 59613.78809135246 61203.36223658097 1.0040743388296265 0.984595673054352 1.1054411913280209 0.9473031887926003 1.0372014052666407 1.0681536281838337 1.0331074537301588 1.080641527441372 0.9740279931176978 1.0 15.901323289800741 -6.4664839491018835 24.999791225620122 1.0381613109314436 1.0124240543258949 0.039825091680023794 0.046942591472856995 874.5917820673218 387704.2937467693 0.014046632239250493 0.015927349351546695 3.415985754437709e-07 6.4664839491018835 -0.02573725660554871 CPS(ph)PTMSLPSSWK ddPTM_A459_Selumetinib_30min_R1 2 CPSPTMSLPSSWK 13 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 CPS(0.5)PT(0.5)MS(0.001)LPSSWK;CPS(0.981)PT(0.019)MSLPSSWK 189.99 0.00016034 212370000.0 5777.1 7094.9 7551.0 8098.5 8417.7 6104.200000000001 6708.6 6638.1 3941.7 5825.1 True False 5911.695189720231 6264.225809670478 6525.615674674021 6684.249002672803 7656.320521265639 6042.797290170148 6202.564900875155 6462.036024412364 6688.777009622485 6572.808326278925 0.8994169457345227 0.9530516483533081 0.9928200170669481 1.01695480392275 1.1648476786786395 0.9193630774246488 0.9436704362846716 0.9831468838938024 1.0176437038152935 1.0 12.68229419900412 -4.981122152398279 2.026085009391848 1.0057069685065716 0.8908607766511913 0.23284405796682495 0.06125837196565213 0.7837937858962465 4.827335137398227 0.017875257310575755 0.1448291571106338 1.0444264159596546e-05 4.981122152398279 -0.11484619185538025 CPS(ph)PTMSLPSSWK ddPTM_A459_Selumetinib_30min_R2 1 CPSPTMSLPSSWK 13 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 CPS(0.857)PT(0.142)MS(0.001)LPSSWK 140.33 0.00088762 78231000.0 30965.0 23525.0 27165.0 29757.0 32812.0 22876.0 27450.0 26624.0 21026.0 27184.0 True False 29244.08926271629 25329.291855202664 25417.233475015677 25704.045266311816 28689.863216998227 26026.96135234774 28726.47939114312 26701.47143215954 25231.787515525844 26399.127287485768 1.1077672736772306 0.9594745909350477 0.9628058230191743 0.9736702651718548 1.0867731688463187 0.9859023394567119 1.088160190990882 1.0114528083213226 0.9557811226391075 1.0 14.688202616753353 -4.744415996605587 24.871619462386892 1.0056508008071197 1.1077675965148 0.3162323820296741 0.04617565670195789 1322.8585258086187 1932622.0143997974 0.011886003873704181 0.3373746883058383 1.8012915154941e-05 4.744415996605587 0.10211679570768029 CPS(ph)QSSSRPAAMISQPPTPPTGQPVR ddPTM_A459_Selumetinib_30min_R1 3 CPSQSSSRPAAMISQPPTPPTGQPVR 26 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 CPS(0.642)QS(0.073)S(0.073)S(0.211)RPAAMIS(0.001)QPPTPPTGQPVR;CPS(0.695)QS(0.052)S(0.052)S(0.199)RPAAMIS(0.002)QPPTPPTGQPVR;CPS(0.88)QS(0.07)S(0.023)S(0.023)RPAAMIS(0.001)QPPT(0.002)PPTGQPVR 71.903 0.00031563 28258300.0 1609.54 1695.9299999999998 1940.81 1908.1399999999999 1731.44 2005.86 1746.37 1492.1999999999998 1016.29 1651.6499999999999 True False 1647.0391503803462 1497.3697271835326 1677.258662106221 1574.9191692239394 1574.8315577105602 1985.6828695751608 1614.639904889446 1452.622008651291 1724.569903115213 1863.6553659333906 0.8837680938693541 0.8034584905313714 0.8999832762889532 0.845069961975056 0.8450229513984329 1.0654775050539744 0.8663833101356547 0.7794477644335072 0.9253695370074401 1.0 10.863919380797954 CPS(ph)QSSSRPAAMISQPPTPPTGQPVR ddPTM_A459_Selumetinib_30min_R2 1 CPSQSSSRPAAMISQPPTPPTGQPVR 26 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 CPS(0.474)QS(0.175)S(0.175)S(0.175)RPAAMIS(0.001)QPPTPPTGQPVR 67.033 0.00075623 37167000.0 15332.0 4667.4 4547.8 11235.0 2523.2 8055.5 10989.0 13309.0 10382.0 12513.0 True False 14479.908818858905 5025.3745719435865 4255.1994992702475 9704.773618543979 2206.213058305798 9165.07200445171 11500.010274290404 13347.726986576437 12458.690097317101 12151.717177321561 1.1915936330284569 0.4135526278806352 0.35017269058990425 0.798633927775718 0.1815556621432234 0.7542203188826884 0.9463691514934678 1.0984231110551979 1.0252616906331917 1.0 13.568872577179514 -7.187569936575899 3.1831436616908215 1.034143758048555 0.5700272843712354 0.37201591479161855 0.2610359309064285 0.26400507079077046 5.232760884387382 0.10828033390429083 0.07880193445254352 6.492770668785002e-08 7.187569936575899 -0.4641164736773197 CPS(ph)QSSSRPAAMISQPPTPPTGQPVREDAK ddPTM_A459_Selumetinib_30min_R1 1 CPSQSSSRPAAMISQPPTPPTGQPVREDAK 30 2 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 CPS(0.537)QS(0.182)S(0.182)S(0.065)RPAAMIS(0.033)QPPTPPTGQPVREDAK 48.20399999999999 0.031344 7623600.0 291.62 378.37 507.4 410.0 268.58 427.39 412.56 283.04 310.22 351.73 True False 298.41417860625836 334.0702645005592 438.49786694869516 338.40119665318844 244.28698642165037 423.0908446390713 381.44026704603846 275.5328597565082 526.4206824276552 396.8779716403301 0.751904111414618 0.8417455449084731 1.104868242337428 0.8526580481515459 0.6155216562209076 1.0660476893953101 0.9611021379430904 0.6942508263124498 1.3264043863455413 1.0 8.632551678826493 -8.262953171561417 24.994102173326993 1.16320218363508 0.8702079370102734 0.3535741591606807 0.16306143045308447 155.09870790075132 2560695.5735462434 0.13068694822605378 0.04077864799294885 5.458167114047187e-09 8.262953171561417 -0.29299424662480666 CPSPT(ph)MSLPSSWK ddPTM_A459_Selumetinib_30min_R2 2 CPSPTMSLPSSWK 13 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 CPS(0.148)PT(0.852)MSLPSSWK;CPS(0.018)PT(0.956)MS(0.026)LPSSWK 170.26 0.00054346 83897700.0 100170.0 87444.0 103935.0 118368.0 116743.0 82833.0 99862.0 89829.0 73161.0 98651.0 True False 94602.95241228129 94150.67362322393 97247.93525587163 102246.07420381087 102076.70064433818 94242.49386689211 104505.78087279896 90090.38751800844 87795.24428913652 95802.68930391977 0.9874770019468608 0.9827560615187423 1.0150856511696351 1.0672568269920943 1.065488885395639 0.9837144922719426 1.0908439171396318 0.9403743065313135 0.9164173253072173 1.0 16.547778534372824 -7.793398183866453 24.997773456675336 0.9462967462651349 1.026621953265287 0.4161259495428471 0.04065571917306487 190.27657870177478 148829.43048493614 0.022490741697336235 0.010805506101407764 1.6091695878896234e-08 7.793398183866453 0.080325207000152 CPSQS(ph)SSRPAAMISQPPTPPTGQPVR ddPTM_A459_Selumetinib_30min_R2 1 CPSQSSSRPAAMISQPPTPPTGQPVR 26 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 CPS(0.042)QS(0.315)S(0.315)S(0.315)RPAAMIS(0.013)QPPT(0.001)PPTGQPVR 64.768 0.00096103 38071000.0 2434.4 3246.6 2121.4 5955.7 5718.9 4068.2 2759.3 4831.2 5818.2 4028.8 True False 2299.105793675328 3495.6037805356395 1984.9114336056784 5144.523385844446 5000.440654385318 4628.557622557315 2887.6129174492235 4845.2579921517845 6982.002574090762 3912.4780759204955 0.5876341666488223 0.8934500622634729 0.5073284488983839 1.3149015243067108 1.2780750607040414 1.1830245518930727 0.7380521657670502 1.2384115381942 1.784547399015928 1.0 11.933866952400788 -5.766375557901212 24.992357875639367 1.2103583723291869 0.6858687817834009 0.48148726158498556 0.26432607989345946 111.43341887953075 564201.9755597007 0.07625592036917186 0.11723111984490057 1.7124757966918152e-06 5.766375557901212 -0.5244895905457859 CPSQSSSRPAAMISQPPT(ph)PPTGQPVR ddPTM_A459_Selumetinib_30min_R2 2 CPSQSSSRPAAMISQPPTPPTGQPVR 26 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 CPSQSSSRPAAMIS(0.001)QPPT(0.91)PPT(0.089)GQPVR;CPSQSSSRPAAMISQPPT(0.972)PPT(0.027)GQPVR 99.873 2.9703e-06 20328000.0 33906.0 36062.1 41996.0 40150.0 41895.0 33579.0 32637.0 32795.7 29290.5 36772.0 True False 32021.6402564721 38827.94711207244 39294.02308178755 34681.50073738681 36631.77555394794 38204.20245018732 34154.68516898862 32891.130057379596 35149.41844494959 35710.29681487002 0.8967060795512085 1.0873039592296028 1.1003555441024855 0.9711904921200539 1.025804286753904 1.0698371578440318 0.9564380085120538 0.9210545134333216 0.9842936514129763 1.0 15.124052504836111 -7.284278732104841 23.374016276491975 0.9588677242905833 1.0290112185707831 0.19279666588377442 0.05898056532138189 523.0787908604688 535319.7530648526 0.024515594809270805 0.01654751573355431 5.196623678940091e-08 7.284278732104841 0.07014349428019984 CPT(ph)PDFEDLPER ddPTM_A459_Selumetinib_30min_R1 1 CPTPDFEDLPER 12 0 H7C4C9;Q3B820-2;Q3B820;Q3B820-3 H7C4C9 FAM161A Protein FAM161A 1 CPT(1)PDFEDLPER 126.32 0.0064352 4368700.0 1003.7 1214.2 1252.5 1241.6 1314.1 1236.9 1327.3 890.59 457.56 874.28 True False 1027.0842571397757 1072.0408995337345 1082.4173794900294 1024.7778677185338 1195.239887023198 1224.457909015343 1227.1806923846389 866.9686601559798 776.4459011398295 986.5023542083637 1.0411371577151254 1.086708911499773 1.0972273658268503 1.03879921152432 1.2115935475717534 1.2412113400357072 1.2439713774118784 0.878830807101007 0.787069486279029 1.0 9.946178683603112 -7.777198744073825 24.975479792707798 0.874712419344348 1.136826416773249 0.6351857224777266 0.08614362244884664 160.03092270846912 253613.73084681196 0.050355347996917245 0.02432000981989005 1.6703260561853757e-08 7.777198744073825 0.26211399742890096 CPT(ph)PDFEDLPER ddPTM_A459_Selumetinib_30min_R2 2 CPTPDFEDLPER 12 0 H7C4C9;Q3B820-2;Q3B820;Q3B820-3 H7C4C9 FAM161A Protein FAM161A 1 CPT(1)PDFEDLPER;CPT(1)PDFEDLPER 109.95 0.017358000000000002 9065000.0 16594.8 13715.9 17339.1 22276.0 20680.7 15951.7 15203.8 15371.8 15097.6 19488.9 True False 15672.527450247839 14767.865426430355 16223.521183384675 19241.97037175662 18082.605578196246 18148.901879884837 15910.806825758164 15416.52939306152 18117.541862189813 18926.204818756694 0.8280861165951073 0.7802866748961079 0.8571988593987135 1.0166840397229024 0.9554269200487355 0.9589298041358236 0.8406760350595942 0.8145599997831086 0.9572728413165296 1.0 14.208097522863172 -5.5286568611076685 24.859825551393445 0.9259278790417522 0.8078254729702765 0.42815959670953874 0.06124111972980224 140.861713184611 606042.9921393523 0.017965163626782476 0.03123442378858937 2.960350534963338e-06 5.5286568611076685 -0.11810240607147571 CPT(ph)PEIQK ddPTM_A459_Selumetinib_30min_R1 1 CPTPEIQK 8 0 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 CPT(1)PEIQK 112.71 0.025857 17618000.0 6034.7 7538.4 6066.7 5187.0 6055.0 5883.1 7098.8 6691.2 3551.9 6583.1 True False 6175.296768517885 6655.800623492914 5242.875461997732 4281.187822048996 5507.326319097076 5823.921355427409 6563.331800723332 6513.727639919259 6027.314879488062 7428.105009824178 0.8313421472031739 0.8960294199786032 0.7058160129755395 0.5763499326391902 0.7414174021252068 0.7840386407737739 0.8835809122303571 0.8769030097588023 0.8114202574568514 1.0 12.858778495207599 -7.157747648329099 3.0889808883835035 0.88408457201043 0.7469797424575331 0.36584896053775073 0.08891482673973017 0.34960819232478185 6.3846104798961925 0.041237465421035444 0.03044323089311698 6.954282866037448e-08 7.157747648329099 -0.13710482955289693 CPT(ph)PEIQK ddPTM_A459_Selumetinib_30min_R2 1 CPTPEIQK 8 0 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 CPT(1)PEIQK 110.54 0.028018 48631000.0 449540.0 317140.0 427800.0 466510.0 418550.0 397130.0 440780.0 443930.0 376080.0 343320.0 True False 424556.36645120266 341463.6182341751 400275.81375342293 402970.53322536295 365968.0071155248 451831.0527127936 461277.1433890002 445221.7628034318 451306.50855317054 333407.4595475135 1.2733859255200606 1.0241631027020062 1.2005604622543848 1.2086428233257214 1.0976599252224322 1.3551917924271988 1.383523764030433 1.335368331013553 1.3536185098127818 1.0 18.346926857500833 -6.765487420303484 24.999961438232685 1.3126249666610785 1.158144612989228 0.193999481615028 0.12083455027785782 133.19442966871588 822578.4680696743 0.03928504683773078 0.035896899479259996 1.7159814142127687e-07 6.765487420303484 -0.15448035367185042 CPT(ph)PVGDGSSSR ddPTM_A459_Selumetinib_30min_R2 1 CPTPVGDGSSSR 12 0 Q5TGY3 Q5TGY3 AHDC1 AT-hook DNA-binding motif-containing protein 1 1 CPT(0.978)PVGDGS(0.02)S(0.002)SR 118.61 0.010478 1809800.0 6353.3 6074.3 7866.5 7745.3 8924.4 5648.9 5806.8 9103.3 7043.5 7052.0 True False 6000.209020275001 6540.179278047082 7360.377954397608 6690.3767786122535 7803.237086851723 6426.98469939138 6076.827705955913 9129.789095867562 8452.396811833269 6848.390436703565 0.8761487937541086 0.9549950953431857 1.074760269938769 0.9769268911356972 1.1394264329660164 0.9384664555552084 0.8873366321796572 1.3331291754244865 1.2342165491227137 1.0 12.741549238889315 -7.758063661481431 24.999985360631 1.2127546501374604 0.9857214160677434 0.4388504867003531 0.1080317754939641 73.53774623759199 544621.0406545715 0.052686804150125034 0.028817650726825215 1.7455662586282724e-08 7.758063661481431 -0.22703323406971698 CQENGQELS(ph)PIALEPGPEPHR ddPTM_A459_Selumetinib_30min_R2 1 CQENGQELSPIALEPGPEPHR 21 0 O94966-2;O94966-7;O94966-6;O94966-5;A0A0A0MR08;H0YB23 O94966-2 USP19 Ubiquitin carboxyl-terminal hydrolase 19 1 CQENGQELS(1)PIALEPGPEPHR 85.84899999999998 0.00070937 2599200.0 11760.0 8623.6 9056.2 9967.7 9728.9 8196.8 6957.3 8496.4 6415.2 8910.9 True False 11106.426279009966 9285.002390755606 8473.533951645024 8610.082064758422 8506.668604530472 9325.834796858016 7280.828235628413 8521.123117345262 7698.419255664476 8653.619163701329 1.2834429235801408 1.0729617533554854 0.9791896074174729 0.9949689143791388 0.9830186010741888 1.0776802884943653 0.8413622205803489 0.9846889441458392 0.8896184486551526 1.0 13.079087915390781 -1.5228788162450555 0.8568974508975045 0.9599398472142078 122.13468976904392 0.7193163386881694 0.06014648819328294 359.62806217187455 0.9704275204060161 0.02036923431355563 84989.747804166 0.029999995097931352 1.5228788162450555 121.17474992182972 CQEVISWLDANTLAEKDEFEHK ddPTM_A459_Selumetinib_30min_R1 2 CQEVISWLDANTLAEKDEFEHK 22 1 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 ; 150.69 1.7791e-07 23813000.0 7076.5 6789.8 9240.0 8304.3 7605.6 7380.9 7614.799999999999 7394.5 5339.6 7403.6 False True 7241.368681527973 5994.847059507615 7985.258751686919 6854.109896017253 6917.674822877741 7306.654847320998 7040.409505289348 7198.373839278893 9060.911211046048 8353.924177170973 0.8668224091998208 0.7176085073754822 0.9558691918114941 0.8204658973022153 0.8280748874620965 0.8746374389281769 0.8427667472167024 0.8616757450289184 1.084629333338586 1.0 13.028238333870735 -8.21713681436481 6.83847552232978 1.0420539304053653 0.8442740200513817 0.64063774686378 0.05882405358346276 0.11836446536851808 15.07343242035356 0.03939975513478701 0.014323083546522654 6.065452215382106e-09 8.21713681436481 -0.19777991035398357 CQSVSS(ph)AGELETENYER ddPTM_A459_Selumetinib_30min_R2 1 CQSVSSAGELETENYER 17 0 Q96RS0 Q96RS0 TGS1 Trimethylguanosine synthase 1 CQSVS(0.092)S(0.908)AGELETENYER 134.4 0.00055588 5270400.0 27734.0 27585.0 31552.0 34884.0 36318.0 28559.0 22334.0 25085.0 25723.0 29091.0 True False 26192.65530799848 29700.68080024506 29521.978671220142 30132.73902174351 31755.408152960536 32492.743017210152 23372.57525398142 25157.99319695471 30868.318760671136 28251.067242504745 0.9271386133190286 1.0513118157730805 1.0449863156604315 1.0666053343431827 1.124042779707217 1.1501421428895138 0.8273165418266586 0.890514789441427 1.0926425715425236 1.0 14.786017748896244 -7.252890605970572 24.99129554859322 0.943494705822092 1.0627103254760382 0.2777323932006711 0.08484521542040711 812.4572354441593 2375123.8419041242 0.03379424378355173 0.02573192917802622 5.5861088498843955e-08 7.252890605970572 0.11921561965394611 CRDPPSNPVAAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 CRDPPSNPVAASPR 14 1 Q9UJJ2;Q8ND82 Q9UJJ2 ZNF280C Zinc finger protein 280C 1 CRDPPSNPVAAS(1)PR 127.61 0.00066116 4813100.0 14702.0 11729.0 17094.0 22676.0 19409.0 15429.0 17170.0 16589.0 15384.0 16402.0 True False 13884.921696769094 12628.576585320807 15994.190650539964 19587.48968171813 16970.66790133849 17554.20469948302 17968.439021709546 16637.271243543204 18461.22986487442 15928.43164248609 0.871706769907822 0.7928323935946373 1.0041284044487138 1.2297186641698101 1.0654324469756602 1.1020673656696047 1.1280733360955715 1.0445015314104382 1.1590111493232371 1.0 13.959316601654482 -5.444644645815297 4.298855169831684 1.1063229065204088 0.8367822822600713 0.7459807166811803 0.06269398150045272 0.09677600024641515 3.2797279510556816 0.01579807773905625 0.03399072049951211 3.5921573668843132e-06 5.444644645815297 -0.2695406242603374 CREMDEQIR ddPTM_A459_Selumetinib_30min_R1 2 CREMDEQIR 9 1 J3KN67;A0A2R2Y2Q3;A0A494C0P6;P06753-2;A0A087WWU8;P06753-3;P06753-6 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 ; 122.19 0.016148 85259000.0 3669.7 2722.64 5267.0 5177.2 4575.1 3499.0 3580.0 3949.9 2585.2 2817.1 False True 3755.19687000681 2403.8720430790045 4551.770329560068 4273.099208080214 4161.283012799508 3463.8032368378103 3309.9577177254628 3845.1358209165874 4386.895584462555 3178.7022258777283 1.1813616385441374 0.7562432314386506 1.4319587070799615 1.3442905011023147 1.3091138197603462 1.0896910093179168 1.0412921634430514 1.2096558745306312 1.3800901351340675 1.0 11.634222158838272 -5.262723395346126 24.999004548612085 1.2290114245095052 0.9688024493669489 0.27268737809972243 0.16779466545210384 140.25748164245533 2730790.9177077026 0.043861798735235394 0.10019970940566084 5.461055681291136e-06 5.262723395346126 -0.26020897514255625 CRS(ph)PGMLEPLGSSR ddPTM_A459_Selumetinib_30min_R1 4 CRSPGMLEPLGSSR 14 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 CRS(1)PGMLEPLGSSR;CRS(1)PGMLEPLGSSR;CRS(0.999)PGMLEPLGSSR;CRS(1)PGMLEPLGSSR 138.28 0.0027536 207861000.0 4296.8099999999995 4022.03 6276.889999999999 6338.3099999999995 4910.6900000000005 4433.9 4201.63 4243.84 2511.34 3461.86 True False 4396.917312863163 3551.1288578089802 5424.522814488758 5231.443143314318 4466.518956552738 4389.2989916590905 3884.6976663482806 4131.279577264906 4261.560558983517 3906.223452371969 1.1256184820131656 0.9090951659850987 1.3886872782955708 1.3392585465477247 1.143436623893224 1.1236681785302847 0.9944893613265731 1.0576147595336045 1.090966917521264 1.0 11.931558764457241 -6.941937569842842 2.7277420549269746 1.0413745198282784 1.1872354016135995 0.2324493110145598 0.12394760532766314 0.47095333117706695 7.111393375760871 0.053700989538304704 0.04478776450520179 1.1430426362156157e-07 6.941937569842842 0.14586088178532108 CRS(ph)PGMLEPLGSSR ddPTM_A459_Selumetinib_30min_R2 5 CRSPGMLEPLGSSR 14 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 CRS(1)PGMLEPLGSSR;CRS(1)PGMLEPLGSSR;CRS(1)PGMLEPLGSSR;CRS(1)PGMLEPLGSSR;CRS(1)PGMLEPLGSSR 118.24 0.001313 488684600.0 37654.200000000004 41511.7 36701.6 47535.8 47031.7 33624.899999999994 36111.6 32359.9 32751.2 41960.5 True False 35561.530305705535 44695.51390884659 34340.25901368069 41061.342036171154 41123.15737726727 38256.42475854857 37790.86095377792 32454.061951530148 39302.355144986665 40748.99133852808 0.8726971916991277 1.0968495769019706 0.8427266021971948 1.0076652375281678 1.0091822159628627 0.9388312078875239 0.9274060464423507 0.7964384119821122 0.964498846572096 1.0 15.31447672824498 -7.174317816737133 3.147537086867625 0.9043475852861983 0.9684839581597094 0.03969897197569727 0.08350383993432849 0.5967295166168932 11.42166191216108 0.033420265669967246 0.024488760919224292 6.693945671333033e-08 7.174317816737133 0.06413637287351115 CS(ph)FILRDCVS(ph)VRFHNLNHGT(ph)SIR ddPTM_A459_Selumetinib_30min_R2 1 CSFILRDCVSVRFHNLNHGTSIR 23 2 Q96MP5 Q96MP5 ZSWIM3 Zinc finger SWIM domain-containing protein 3 3 CS(1)FILRDCVS(1)VRFHNLNHGT(0.525)S(0.475)IR 59.21100000000001 0.042899 0.0 946.56 1186.5 974.69 2144.4 2936.5 912.98 2010.9 2275.5 1208.7 928.52 True False 893.9539845799037 1277.5007348011882 911.9795065622326 1852.3290207036684 2567.5906173569197 1038.734707792728 2104.4108345227555 2282.121328270695 1450.4737738997464 901.7112150153141 0.9913972119829089 1.4167515203628602 1.0113875610904364 2.0542375317714217 2.847464437173839 1.1519593973055848 2.3337968958132738 2.5308782792858318 1.6085790547421688 1.0 9.816521654991968 -5.766443239366488 24.73400777501314 2.018535355664627 1.167535967469556 0.2881954450539552 0.5589482479914845 120.63257471869193 596289.709048353 0.15075566335557836 0.23174184993009658 1.7122089412626516e-06 5.766443239366488 -0.850999388195071 CS(ph)PLEPDFVPDEK ddPTM_A459_Selumetinib_30min_R2 1 CSPLEPDFVPDEK 13 0 Q5JSZ5;A0A494C0D3 Q5JSZ5 PRRC2B Protein PRRC2B 1 CS(1)PLEPDFVPDEK 138.55 0.00098199 1796900.0 16794.0 17992.0 18662.0 20688.0 17020.0 20149.0 17816.0 19042.0 14269.0 18162.0 True False 15860.65671170862 19371.92854660175 17461.307237649275 17870.258711209426 14881.79543926946 22924.34185558905 18644.47930173426 19097.409067427197 17123.198709171418 17637.615869456917 0.8992517372585793 1.0983303350056595 0.9900038285722643 1.0131901524261777 0.8437532345309937 1.2997415311265035 1.05708614133166 1.0827659026466387 0.9708340875494224 1.0 14.106367940117803 CSATPSAQVKPIVS(ph)ASPPSR ddPTM_A459_Selumetinib_30min_R2 1 CSATPSAQVKPIVSASPPSR 20 1 Q96EV2;H0Y3K4 Q96EV2 RBM33 RNA-binding protein 33 1 CSATPSAQVKPIVS(0.458)AS(0.458)PPS(0.084)R 61.437 0.014488999999999997 51413000.0 33522.0 25130.0 29488.0 39428.0 40251.0 26201.0 35807.0 30288.0 24801.0 27051.0 True False 31658.981439198313 27057.390194314274 27590.774184106864 34057.83838290626 35194.30953149442 29809.949921002953 37472.09645022446 30376.133065551683 29761.892997838677 26269.96734306129 1.2051397333602103 1.0299742607583016 1.0502782064323517 1.2964552996257146 1.339716531501145 1.134753977106739 1.4264234119850172 1.1563064646738117 1.1329246286900967 1.0 14.681126786567138 -4.431621168515547 21.345733974551543 1.1864572695491682 2.86274184094495 0.0 0.13319825272310087 7307.584991335154 1628505.3356779192 0.033090158626967375 28139.945541838257 3.701509185833173e-05 4.431621168515547 1.6762845713957817 CSATPSAQVKPIVSAS(ph)PPSR ddPTM_A459_Selumetinib_30min_R1 1 CSATPSAQVKPIVSASPPSR 20 1 Q96EV2;H0Y3K4 Q96EV2 RBM33 RNA-binding protein 33 1 CSATPSAQVKPIVS(0.073)AS(0.901)PPS(0.027)R 114.64 0.0001508 29848000.0 1960.2 1547.7 2388.1 2126.1 2182.1 2119.3 2045.1 2144.0 1397.8 2238.4 True False 2005.868846114764 1366.4945644937911 2063.8091368943215 1754.8165468398631 1984.7294402810444 2097.9817661704396 1890.8364604805433 2087.134155306505 2371.964508727279 2525.720443862379 0.7941769054406321 0.5410315966735108 0.8171170098850314 0.6947786130108544 0.7858072515919295 0.8306468640536349 0.7486325199114439 0.82635200597055 0.9391239297647789 1.0 11.30247924976826 -7.96776877173314 0.32798445415186545 1.0282411019534894 0.6669007001987228 0.5841408718867172 0.0769108511076825 0.9397061056546336 0.33947324379925636 0.12258541718041682 0.10815525241797226 1.0770385008123266e-08 7.96776877173314 -0.36134040175476656 CSATPSAQVKPIVSAS(ph)PPSR ddPTM_A459_Selumetinib_30min_R2 1 CSATPSAQVKPIVSASPPSR 20 1 Q96EV2;H0Y3K4 Q96EV2 RBM33 RNA-binding protein 33 1 CSATPSAQVKPIVS(0.137)AS(0.826)PPS(0.036)R 86.508 0.0012432 36662000.0 13539.0 12018.0 14491.0 20685.0 18000.0 12676.0 16422.0 14832.0 12189.0 11254.0 True False 12786.556580911212 12939.741956039343 13558.664836607855 17867.667316384708 15738.679077958297 14422.003938728796 17185.65553957567 14875.158664430217 14627.1405891156 10929.06777859641 1.169958576517617 1.18397490235907 1.2406057965127888 1.6348756983076742 1.4400751643960956 1.3196005579700938 1.5724722261520072 1.3610638131059876 1.3383703793805295 1.0 13.41588272762669 -5.542211240344905 24.874402246064896 1.4064641463041652 1.185797547862068 0.20721444883060625 0.16142204056718842 271.5388710186141 349377.42042239674 0.04144753883082451 0.07180092947369898 2.8693845771309478e-06 5.542211240344905 -0.22066659844209724 CSDAAGYPHATHDLEGPPLDAYSIQGQHT(ph)ISPLDLAK ddPTM_A459_Selumetinib_30min_R1 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK 37 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 CSDAAGYPHATHDLEGPPLDAY(0.179)S(0.084)IQGQHT(0.718)IS(0.02)PLDLAK 74.476 9.3353e-07 4812100.0 966.48 747.02 1039.2 1211.5 1284.3 1005.6 1137.6 1032.3 341.08 574.25 True False 988.9971035572889 659.5585511198238 898.0823479169965 999.9342676715554 1168.1352917615811 995.484577011747 1051.7899161129853 1004.9200506170265 578.7878485024322 647.9605811686796 1.5263229466420727 1.0178991906116046 1.3860138625982314 1.5432023131222679 1.802787585711927 1.5363350888047287 1.6232313302391759 1.5508968906789438 0.8932454617200856 1.0 9.339762238868794 -8.26155761197583 24.99999977958765 0.9466226656577944 1.4956512416386418 0.5719236974428744 0.19091469442754633 8.38259948892648 1771382.8874372824 0.16744401132410672 0.05369296056349862 5.47573456978103e-09 8.26155761197583 0.5490285759808474 CSDAAGYPHATHDLEGPPLDAYSIQGQHT(ph)ISPLDLAK ddPTM_A459_Selumetinib_30min_R2 2 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK 37 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 CSDAAGYPHATHDLEGPPLDAY(0.037)S(0.042)IQGQHT(0.538)IS(0.383)PLDLAK;CSDAAGYPHATHDLEGPPLDAY(0.019)S(0.079)IQGQHT(0.801)IS(0.102)PLDLAK 76.749 7.167799999999998e-07 36131000.0 38470.0 33338.0 43967.0 78343.0 83088.0 55930.0 65178.0 63096.0 57278.0 66630.0 True False 36331.99140761166 35894.91740143448 41138.21108765008 67672.54825078684 72649.74262385558 63633.849818010596 68208.90614775686 63279.5989138949 68735.20048103716 64706.21877446943 0.5614914933330467 0.5547367483571336 0.635769047655766 1.0458430353758796 1.1227629121255398 0.9834271113848188 1.0541321597773452 0.9779523531494407 1.0622657571849556 1.0 15.981616752724632 -5.719577148903398 4.594154505101191 1.0379275353488095 0.5687814440626981 0.9608881056417294 0.041842129632980764 0.0340724411042446 1.5769481183004253 0.011796239021236563 0.020346824049960025 1.9073168744721077e-06 5.719577148903398 -0.4691460912861114 CSDAAGYPHATHDLEGPPLDAYSIQGQHTIS(ph)PLDLAK ddPTM_A459_Selumetinib_30min_R2 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK 37 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 CSDAAGYPHATHDLEGPPLDAY(0.012)S(0.011)IQGQHT(0.372)IS(0.606)PLDLAK 52.956 0.001125 18120000.0 15885.0 16409.0 19383.0 29842.0 25858.0 17660.0 20633.0 22648.0 21765.0 24852.0 True False 15002.1752926933 17667.51753674901 18135.91888261472 25777.468119678622 22609.48686654699 20092.504698481443 21592.475383513873 22713.901930421765 26118.608164911042 24134.458186749434 0.6216081246410562 0.7320453353474918 0.7514533262889614 1.0680773490009918 0.9368135257728843 0.8325235455052747 0.8946741300937433 0.9411399151646338 1.0822123274037685 1.0 14.558806818510801 -5.6142050674675374 5.646674452461091 0.9524095118562153 0.6919009680007634 0.7193140604008884 0.07583938146165962 0.1166810405818162 5.718400327483583 0.02197980401563082 0.03869861843139126 2.4310558292073423e-06 5.6142050674675374 -0.26050854385545186 CSDVSELS(ph)SSPPGPYHQEPYVCKPEER ddPTM_A459_Selumetinib_30min_R1 1 CSDVSELSSSPPGPYHQEPYVCKPEER 27 1 Q9Y478;F5H610;F5H2X8 Q9Y478 PRKAB1 5-AMP-activated protein kinase subunit beta-1 1 CSDVS(0.077)ELS(0.344)S(0.289)S(0.289)PPGPY(0.001)HQEPYVCKPEER 110.9 5.299800000000001e-10 86818000.0 571.62 501.77 667.24 474.94 1260.7 545.34 571.72 694.67 286.53 450.72 True False 584.9376338211005 443.0225351334554 576.6324728869678 392.0006447279642 1146.6699075946624 539.8543747291029 528.5947001055873 676.2450949938295 486.220482676797 508.5743023845838 1.1501517695221075 0.8711068039738308 1.133821489177246 0.7707834290682138 2.254675279930976 1.0615054126758947 1.0393657281288744 1.3296878977625832 0.9560461084978634 1.0 8.990314756091076 CSDVSELS(ph)SSPPGPYHQEPYVCKPEER ddPTM_A459_Selumetinib_30min_R2 1 CSDVSELSSSPPGPYHQEPYVCKPEER 27 1 Q9Y478;F5H610;F5H2X8 Q9Y478 PRKAB1 5-AMP-activated protein kinase subunit beta-1 1 CS(0.003)DVS(0.075)ELS(0.327)S(0.292)S(0.292)PPGPY(0.012)HQEPYVCKPEER 57.922 0.0039294 32156000.0 24779.0 15680.0 17845.0 24257.0 29317.0 19747.0 23706.0 24572.0 19273.0 19014.0 True False 23401.882378196246 16882.60558085347 16696.872128166942 20953.15475434102 25633.93636269465 22466.970004581694 24808.37597254784 24643.500451886426 23128.1385326134 18465.016415695052 1.2673632046330008 0.914302224313402 0.9042435572369593 1.1347487747983305 1.388243356280263 1.2167316561649535 1.3435339245873081 1.3346048493593394 1.2525382058666759 1.0 14.172506924672522 -6.010843941477812 7.198251106095794 1.2742549731146104 1.0169481826161872 0.35532069037542924 0.13653129949101894 0.13257466696417136 40.600775123248425 0.03799412757891585 0.0525536591427792 9.753400515247123e-07 6.010843941477812 -0.2573067904984232 CSDVSELSS(ph)SPPGPYHQEPYVCKPEER ddPTM_A459_Selumetinib_30min_R2 5 CSDVSELSSSPPGPYHQEPYVCKPEER 27 1 Q9Y478;F5H610;F5H2X8 Q9Y478 PRKAB1 5-AMP-activated protein kinase subunit beta-1 1 CS(0.001)DVS(0.011)ELS(0.113)S(0.437)S(0.437)PPGPYHQEPYVCKPEER;CSDVS(0.004)ELS(0.088)S(0.45)S(0.45)PPGPY(0.008)HQEPYVCKPEER;CSDVSELS(0.034)S(0.482)S(0.482)PPGPY(0.002)HQEPYVCKPEER;CSDVS(0.014)ELS(0.204)S(0.363)S(0.363)PPGPY(0.055)HQEPYVCKPEER;CSDVS(0.002)ELS(0.059)S(0.461)S(0.461)PPGPY(0.016)HQEPYVCKPEER 92.136 7.5775e-06 404025000.0 264827.0 195686.0 255458.0 305235.0 298910.0 229094.0 247495.0 251752.0 220399.0 246155.0 True False 250108.97552647698 210694.4869703374 239022.1104016402 263661.46644025616 261358.25351069524 260649.6189917272 259004.00790203857 252484.55664021295 264484.95846258843 239047.86556250168 1.046271527829573 0.8813903712319449 0.999892259398339 1.1029651564544882 1.0933302119041939 1.0903658076109344 1.083481784255125 1.0562092074994833 1.1064100398480068 1.0 17.866939998482003 -5.6063848452624585 4.856346078745563 1.0795930039550188 0.9584977554978079 0.4934948203311522 0.04718162480633099 0.13846634966065657 5.7378890137240335 0.011981564163196925 0.021436998634673608 2.475227689817642e-06 5.6063848452624585 -0.12109524845721087 CSGPGLS(ph)PGMVR ddPTM_A459_Selumetinib_30min_R1 5 CSGPGLSPGMVR 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 CSGPGLS(1)PGMVR;CSGPGLS(1)PGMVR;CSGPGLS(1)PGMVR;CSGPGLS(1)PGMVR;CSGPGLS(1)PGMVR 174.46 0.00014188 624299000.0 18690.6 18493.800000000003 23852.0 24395.500000000004 20304.3 19259.899999999998 19816.300000000003 19201.0 13273.2 18073.7 True False 19126.05461442332 16328.537298465633 20613.029409657625 20135.283885250887 18467.779650015316 19066.162892590026 18321.540536805333 18691.727106362046 22523.650963828095 20393.635447746383 0.9378442928152303 0.8006682938068325 1.0107579623296388 0.9873317553823369 0.9055658417222573 0.9349075078566705 0.89839502053225 0.9165470842241418 1.104445110904299 1.0 14.315831358186179 -8.248644131588327 24.824390869336572 1.0522225529590197 0.9237893167575028 0.4393630982085396 0.05793525595624634 562.3824134298605 1091098.7918563436 0.03989966601448185 0.014861954812234068 5.640996995494066e-09 8.248644131588327 -0.12843323620151692 CSGPGLS(ph)PGMVR ddPTM_A459_Selumetinib_30min_R2 5 CSGPGLSPGMVR 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 CSGPGLS(1)PGMVR;CS(0.005)GPGLS(0.995)PGMVR;CSGPGLS(1)PGMVR;CSGPGLS(1)PGMVR;CS(0.017)GPGLS(0.983)PGMVR 133.04 0.0017982 537680000.0 482104.0 367824.0 469750.0 498150.0 414903.0 354370.0 434665.0 408392.0 351600.0 403245.0 True False 455310.5896952231 396034.918059428 439526.79642512836 430301.1106433174 362779.1758601185 403181.25084942643 454877.78377235716 409580.35310706496 421929.8245248218 391602.26909366495 1.1626862907332136 1.011319262720367 1.122380617054087 1.0988218011075832 0.9263970219062945 1.0295682192612423 1.1615810726151787 1.0459090394317914 1.0774447898408448 1.0 18.579029598930752 -4.745541182422312 24.738577665245806 1.0564038545343684 1.1626866300991576 0.20974282742546924 0.06372069728513897 1395.5405230649728 2171412.0350685497 0.016259932539951307 0.39874553130857604 1.7966307047354312e-05 4.745541182422312 0.10628277556478927 CSLHSAS(ph)PASVR ddPTM_A459_Selumetinib_30min_R1 1 CSLHSASPASVR 12 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 CSLHS(0.001)AS(0.998)PASVR 214.61 1.4691e-06 9947100.0 2891.5 2439.2 3227.2 3009.6 4163.6 2754.5 4205.1 3393.7 1170.7 2258.7 True False 2958.866324120417 2153.617330046685 2788.963965740695 2484.0298571888675 3787.003115143286 2726.792230885895 3887.905921454567 3303.68805170881 1986.5923954550178 2548.626146601125 1.1609652235838483 0.8450110789763229 1.0943009312919774 0.974654466486423 1.4858998131968761 1.0699067160251707 1.5254908714797262 1.2962623239640867 0.7794757964420787 1.0 11.315504047193933 CSLHSAS(ph)PASVR ddPTM_A459_Selumetinib_30min_R2 1 CSLHSASPASVR 12 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 CSLHS(0.054)AS(0.942)PAS(0.004)VR 98.421 0.01012 8546700.0 44677.0 41060.0 58942.0 90705.0 85871.0 58103.0 53720.0 62057.0 62502.0 61920.0 True False 42194.031196201366 44209.16997129102 55149.735891197335 78350.82252514735 75083.11728351981 66106.16084348052 56218.08644416057 62237.57559591057 75004.14645179287 60132.208712519074 0.7016876994810418 0.7351995031921553 0.9171413635387647 1.302975962511673 1.2486339499431702 1.0993469599548855 0.9349080575591162 1.0350122992065178 1.2473206632135163 1.0 15.875850330600905 -5.490352393119918 3.878279927632073 1.1222663980009955 0.7282097367911848 0.6778396879758031 0.11225552215232573 0.1368934682930135 4.408166669705901 0.03340780255921403 0.07000440359049408 3.233311946329772e-06 5.490352393119918 -0.39405666120981064 CSPTVAFVEFPS(ph)SPQLK ddPTM_A459_Selumetinib_30min_R2 1 CSPTVAFVEFPSSPQLK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 CSPTVAFVEFPS(0.994)S(0.006)PQLK 210.67 3.2818000000000004e-09 7686600.0 49467.0 39326.0 38717.0 50705.0 48498.0 38347.0 51353.0 51121.0 39603.0 49736.0 True False 46717.82217209066 42342.177746979825 36225.990371882304 43798.89152899622 42405.24766237898 43628.951170592736 53741.01625403906 51269.75364646286 47524.70660027444 48299.99245035286 0.9672428462615497 0.8766497798214561 0.7500206218276055 0.9068094901674512 0.8779555753754404 0.9032910556960967 1.1126506139577346 1.0614857486605735 0.9839485306157071 1.0 15.559735343106578 -7.129834672900422 5.3112536135117985 1.0438573698065785 0.8724074216315371 0.6296437856741108 0.059963138083574605 0.1495808323526872 5.836995981746656 0.024046423495846674 0.018550129473880805 7.415924967933312e-08 7.129834672900422 -0.17144994817504144 CSPTVAFVEFPSS(ph)PQLK ddPTM_A459_Selumetinib_30min_R1 2 CSPTVAFVEFPSSPQLK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 CSPTVAFVEFPS(0.215)S(0.785)PQLK;CSPTVAFVEFPS(0.226)S(0.774)PQLK 205.33 1.025e-08 21128200.0 3672.3999999999996 3652.8 3621.6000000000004 3723.3 3797.6 3343.6000000000004 4333.6 4560.0 2898.5 3995.2 True False 3757.9597747535217 3225.1284778593526 3129.806612024821 3073.095549997113 3454.1077505207354 3309.966419745901 4006.713062998623 4439.053987032496 4918.542801935911 4508.022836543506 0.8336159578186411 0.7154197294023019 0.6942747908581087 0.6816947609682888 0.7662134544928676 0.7342390532972086 0.8887960882804093 0.9847008650994564 1.0910643047467719 1.0 12.13827910853172 -7.556084992798175 1.7806991606560079 1.044407107119219 0.7300008505302155 0.8877450032224219 0.04623495657205062 0.10984337009721366 0.6818597668719281 0.030084404119866067 0.01447463397740982 2.7791693223440968e-08 7.556084992798175 -0.31440625658900345 CSPTVAFVEFPSS(ph)PQLK ddPTM_A459_Selumetinib_30min_R2 1 CSPTVAFVEFPSSPQLK 17 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 CSPTVAFVEFPS(0.241)S(0.759)PQLK 71.545 0.029453 6268000.0 19925.0 15859.0 19044.0 18894.0 18734.0 16098.0 20345.0 20169.0 16873.0 17568.0 True False 18817.648266094697 17075.33430527776 17818.72977353944 16320.604606032033 16380.467435915045 18315.353376905674 21291.082812852692 20227.688450842306 20248.07147101054 17060.766192854262 1.1029779116237046 1.0008538955553825 1.0444272884416317 0.9566161578879008 0.9601249586771693 1.0735363916174459 1.2479558404457975 1.1856260277052786 1.1868207583485464 1.0 14.058394818574332 -7.030093324364758 6.380945694758014 1.1699413891576476 1.0112219076425097 0.46414049950844427 0.07123652219164033 0.14940616994395758 20.340746900972928 0.026060925735506408 0.02079572684517449 9.330537778540682e-08 7.030093324364758 -0.15871948151513782 CSS(ph)PTVGPPPLPQK ddPTM_A459_Selumetinib_30min_R1 1 CSSPTVGPPPLPQK 14 0 E9PI79;H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 E9PI79;H0YDJ2 PPFIBP2 Liprin-beta-2 1 CS(0.12)S(0.754)PT(0.125)VGPPPLPQK 184.96 1.0261e-14 0.0 2121.1 2089.6 2907.6 3192.4 2576.3 2462.9 2383.9 2365.7 1519.8 1775.6 True False 2170.517503057864 1844.9486605713146 2512.763890303559 2634.907268769851 2343.2741198827075 2438.125462134279 2204.0805037111 2302.9539511234143 2578.989598199827 2003.5155558086308 1.0833544550053817 0.9208556705349275 1.25417737986536 1.315141906999762 1.1695811959577964 1.216923649564696 1.1001065089417386 1.1494564863480325 1.2872321309024883 1.0 10.968317995928599 -5.265253380484609 24.9968431182845 1.1938952703017516 1.0021050595060075 0.3757704717407757 0.09472981893223029 290.65982995864437 1904988.729895126 0.024040250296468023 0.053301046548653495 5.429334753233977e-06 5.265253380484609 -0.1917902107957441 CSS(ph)PTVGPPPLPQK ddPTM_A459_Selumetinib_30min_R2 3 CSSPTVGPPPLPQK 14 0 E9PI79;H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 E9PI79;H0YDJ2 PPFIBP2 Liprin-beta-2 1 CS(0.027)S(0.527)PT(0.446)VGPPPLPQK;CS(0.072)S(0.907)PT(0.021)VGPPPLPQK;CS(0.114)S(0.772)PT(0.114)VGPPPLPQK 175.21 7.1577e-05 27600000.0 119500.0 109501.0 126298.0 135988.0 141862.0 105544.0 104019.0 110316.0 81217.0 117880.0 True False 112858.66839640234 117899.37459879044 118172.12418286515 117466.1998076151 124040.02729762896 120081.72796696052 108856.08960973832 110637.001296203 97462.66939258343 114476.4981109782 0.9858675820690509 1.0299002550243455 1.0322828365024257 1.0261162923916363 1.0835414198063562 1.0489640227337176 0.9509033854635279 0.9664603924986155 0.8513771036051359 1.0 16.8046919195805 -7.339121997733337 4.336136729507944 0.9366328464321242 1.0360048362233087 0.5403931495079184 0.0416581195007115 0.17381138230037155 6.12483400178204 0.017954522955899943 0.011898206527938786 4.580132080772581e-08 7.339121997733337 0.09937198979118456 CSS(ph)VTGVQR ddPTM_A459_Selumetinib_30min_R2 1 CSSVTGVQR 9 0 A0A3B3IRT3;O60343-2;O60343-3;O60343 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 CS(0.013)S(0.73)VT(0.257)GVQR 94.363 0.023342 4857400.0 40747.0 36144.0 43803.0 46269.0 45238.0 34152.0 30672.0 33659.0 25383.0 39633.0 True False 38482.44486316486 38916.12857872242 40984.762669100404 39967.08238152305 39554.79800714876 38856.1279990112 32098.308775415 33756.9421174526 30460.30926027738 38488.69231109931 0.9998376809509674 1.0111055024724716 1.0648520437593896 1.0384110236449213 1.027699192464952 1.00954658799374 0.833967247210385 0.8770612897055436 0.7914093057272638 1.0 15.23214703463322 -7.2012748936886455 5.580594276693038 0.8654673259768144 1.0283410183630737 0.6602425473674345 0.05241921932574048 0.1169107116508023 7.636400788552566 0.0192926256573639 0.014722601685107117 6.291078528556392e-08 7.2012748936886455 0.16287369238625926 CSSCEPFPDGATNNLS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 CSSCEPFPDGATNNLSR 17 0 O95999 O95999 BCL10 B-cell lymphoma/leukemia 10 1 CSSCEPFPDGAT(0.097)NNLS(0.903)R;CSSCEPFPDGAT(0.068)NNLS(0.932)R 74.812 0.022787 7317300.0 74118.0 64342.0 69798.0 84027.0 70929.0 51923.0 63152.0 58813.0 44223.0 56303.0 True False 69998.81827786224 69276.82450786188 65307.27267031641 72582.37764533992 62018.26490669469 59074.92193993494 66088.69313331402 58984.13609298368 53068.83569385995 54677.38609723778 1.280215154275608 1.2670105404208714 1.1944110231270846 1.3274661213003134 1.1342580421895436 1.0804269581372565 1.2087024975148313 1.0787665670060893 0.970581066173917 1.0 15.738656654777794 -7.211939873800336 0.4842276345003663 0.9799004319753054 1.2874884624745226 0.7212332752364853 0.06071548574804143 0.5583623382045759 0.28577913719813536 0.06131094532194994 0.059477765696762136 6.138469837520598e-08 7.211939873800336 0.30758803049921724 CSVCPDYDLCS(ph)VCEGK ddPTM_A459_Selumetinib_30min_R1 1 CSVCPDYDLCSVCEGK 16 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 1 CSVCPDYDLCS(1)VCEGK 95.767 0.0085191 5333800.0 2277.0 1831.4 2329.9 2500.8 2235.3 1928.7 1775.7 2191.1 1611.0 2069.4 True False 2330.049669729271 1616.9788366052392 2013.5123772246066 2064.082225829985 2033.1175096742688 1909.2990291194876 1641.7575193757286 2132.984910304144 2733.7493372153695 2335.0276476629783 0.9978681289111546 0.6924880903331483 0.8623077243816956 0.8839647906935191 0.8707038273011981 0.8176772686312375 0.7030998202607529 0.9134730856137614 1.1707567317035639 1.0 11.189223916785517 -8.06316251069887 5.584321429061627 1.078086187578003 0.8295400512639941 0.542625223005945 0.09159851232787632 0.15791672054153974 9.747879956207521 0.06038460318100023 0.022546459303523985 8.646443129034373e-09 8.06316251069887 -0.2485461363140089 CSVCPDYDLCS(ph)VCEGK ddPTM_A459_Selumetinib_30min_R2 2 CSVCPDYDLCSVCEGK 16 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 1 CSVCPDYDLCS(1)VCEGK;CSVCPDYDLCS(1)VCEGK 117.07 0.0018709 11566300.0 81534.0 54484.0 68628.0 86442.0 77687.0 69560.0 85603.0 74687.0 62866.0 66248.0 True False 77002.66668646238 58662.74760632783 64212.54919651676 74668.45047923263 67927.26452940819 79141.25859718966 89583.70911912662 74904.32680490155 75440.95662280267 64335.24810702465 1.1968970191638166 0.9118290413482146 0.9980928198131175 1.1606149455585875 1.0558327903921043 1.2301383910968142 1.392451443881898 1.164281307818923 1.172622455691834 1.0 15.973321759966526 -6.758434500497256 24.881284322283438 1.2147008591679374 1.0577964564870348 0.21549851343645698 0.11706333763902803 95.90007775915721 794082.9369769685 0.03942104078129369 0.037798271376894815 1.7440763760537512e-07 6.758434500497256 -0.15690440268090255 CT(ph)CPDQFPMIK ddPTM_A459_Selumetinib_30min_R2 1 CTCPDQFPMIK 11 0 A0A5E8;Q99501;Q99501-3;Q99501-2;Q99501-4 A0A5E8 GAS2L1 GAS2-like protein 1 1 CT(1)CPDQFPMIK 90.861 0.036918 3646400.0 1224.8 1395.3 10476.0 5798.1 15760.0 7729.8 4056.2 3999.2 18889.0 4996.7 True False 1156.7305192628737 1502.3150234033694 9801.985565406387 5008.38877771961 13780.087903812382 8794.50978586194 4244.82133720782 4010.8370098968 22667.327802756958 4852.432288014278 0.23838158898580597 0.30960040949240114 2.0200149087330335 1.0321398590332833 2.8398310550050967 1.8123920672906175 0.8747821886546909 0.8265621799203142 4.6713331495106605 1.0 12.24449236603429 -5.256166824209022 22.393746887762124 1.8434598121345394 0.2739899538794385 0.2506805425153623 1.1120421876773463 140.98637331552726 598775.5627878642 0.2778078137199798 0.6864087553884438 5.544127071949414e-06 5.256166824209022 -1.569469858255101 CT(ph)HT(ph)LVPT(ph)PGY(ph)FFIA ddPTM_A459_Selumetinib_30min_R1 2 CTHTLVPTPGYFFIA 15 0 H0YN01 H0YN01 TLN2 4 CT(1)HT(1)LVPT(1)PGY(1)FFIA;CT(1)HT(1)LVPT(1)PGY(1)FFIA 64.53399999999999 0.026558 99238000.0 0.0 125.65 127.03 204.97 0.0 0.0 0.0 213.34 0.0 0.0 True False 0.0 110.93883958689977 109.78002372584301 169.17583726342457 0.0 0.0 0.0 207.68153017401573 0.0 0.0 0.0 CTDAIVS(ph)FISR ddPTM_A459_Selumetinib_30min_R1 1 CTDAIVSFISR 11 0 Q9BYK8-2;Q9BYK8-4;Q9BYK8 Q9BYK8-2 HELZ2 Helicase with zinc finger domain 2 1 CTDAIVS(0.983)FIS(0.017)R 76.282 0.034181 4441900.0 1564.7 1912.1 1883.1 1972.0 2240.2 2123.6 1875.8 1790.6 1079.1 1265.3 True False 1601.1544656237984 1688.2304430888269 1627.3853631278835 1627.6272190246048 2037.5743055394325 2102.2385120745266 1734.3068957847554 1743.1074713114876 1831.1538856543177 1427.7135800657034 1.1214815688382773 1.1824713770748994 1.139854229762941 1.1400236306148335 1.4271590142370596 1.4724511564692 1.2147442736413159 1.2209083780174381 1.2825779002326558 1.0 10.479490867625278 -6.202222020922638 24.980659795761266 1.2880815241421761 1.1481297039659644 0.18944550545345362 0.12176626540974447 392.4207778857772 165540.83157317017 0.036254540044267064 0.046804405911090474 6.277373635779701e-07 6.202222020922638 -0.13995182017621177 CTELNQAWSS(ph)LGK ddPTM_A459_Selumetinib_30min_R1 2 CTELNQAWSSLGK 13 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 CTELNQAWS(0.023)S(0.977)LGK;CTELNQAWS(0.233)S(0.767)LGK 187.63 0.00014234 23233000.0 4439.700000000001 5173.1 5138.3 5481.0 5126.4 4873.6 5196.4 5633.1 2971.3 4809.299999999999 True False 4543.136371847624 4567.431047091056 4440.547082661568 4523.846241112503 4662.718025139428 4824.576008874751 4804.431364354357 5483.69188911244 5042.079084834285 5426.620501549026 0.8371944141940252 0.8416713580371588 0.8182895931996749 0.8336396915577887 0.8592305328534505 0.8890571963706654 0.8853450067095967 1.0105169299285113 0.9291379567439857 1.0 12.405838305250098 -7.383287846571882 0.9597489552408867 0.9873468600057869 0.8318612301443596 0.8307523458613597 0.026840858150638913 0.2063892200475562 0.35984339764127055 0.01989833807593342 0.010377553167992137 4.1372537038123534e-08 7.383287846571882 -0.15548562986142722 CTELNQAWSS(ph)LGK ddPTM_A459_Selumetinib_30min_R2 4 CTELNQAWSSLGK 13 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 CTELNQAWS(0.092)S(0.908)LGK;CTELNQAWS(0.02)S(0.98)LGK;CTELNQAWS(0.182)S(0.818)LGK;CTELNQAWS(0.037)S(0.963)LGK 153.41 0.00041231 13500800.0 138827.0 117681.0 139360.0 145676.0 143973.0 108854.0 111967.0 131991.0 96005.0 124712.0 True False 131111.55110851311 126706.75429594514 130393.72932369554 125834.67749488301 125885.82460504938 123847.65042177212 117173.68735840157 132375.07195771355 115208.68260382675 121111.24051931035 1.0825712836093715 1.0462014405322075 1.0766443210769125 1.0390008140889246 1.039423129226207 1.0225941860617427 0.9674881279060059 1.0930040134186163 0.9512633353421686 1.0 16.88597324441453 -6.3242529407400765 0.9478214175251617 1.007756564343795 1.0695475295313812 0.3456120918658384 0.036510278544911026 0.70295298308038 1.3518640852431798 0.01706622522846758 0.0252530372510272 4.7396585881028983e-07 6.3242529407400765 0.06179096518758631 CTGDFSPS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 CTGDFSPSPEK 11 0 A0A2R8YH03;Q5VWN6;Q5VWN6-2 A0A2R8YH03 FAM208B Protein FAM208B 1 CTGDFS(0.078)PS(0.922)PEK 145.81 0.00069526 18399000.0 4510.9 5153.1 5341.0 4990.1 4309.1 4391.8 4398.6 4669.8 2946.1 4326.1 True False 4615.995193316545 4549.772656388805 4615.7215360129685 4118.672710778234 3919.342665833395 4347.622479435348 4066.8100606668236 4545.94173435183 4999.316525369463 4881.397074782452 0.9456299339308029 0.932063625779014 0.9455738726640418 0.8437487562844476 0.8029141259744921 0.8906512649617031 0.8331242057066353 0.93127882544864 1.0241569060620348 1.0 12.253078396467329 -8.08940055418257 3.9762846535402403 1.0097314882917536 0.8841946980577889 0.5431214057974258 0.046094999539811825 0.19931395935184318 5.563520852528486 0.038012897761549085 0.013370359695451611 8.139532204495446e-09 8.08940055418257 -0.1255367902339647 CTGDFSPS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 4 CTGDFSPSPEK 11 0 A0A2R8YH03;Q5VWN6;Q5VWN6-2 A0A2R8YH03 FAM208B Protein FAM208B 1 CTGDFS(0.122)PS(0.878)PEK;CTGDFS(0.003)PS(0.997)PEK;CT(0.001)GDFS(0.266)PS(0.732)PEK;CTGDFS(0.307)PS(0.693)PEK 131.06 0.0022751 65180000.0 375102.0 342667.0 378494.0 360372.0 345245.0 258692.0 340339.0 311217.0 235735.0 311290.0 True False 354255.33249227883 368948.4570519325 354142.10811310867 311288.7119236248 301872.23657053965 294324.4748278348 356165.43786893476 312122.5899452524 282888.58698623074 302302.24887144886 1.1718580785117563 1.2204621647020044 1.1714835381979054 1.0297267489266921 0.9985775418392866 0.9736099414629016 1.1781766070168758 1.0324851737308098 0.9357806236715308 1.0 18.20563218586561 -5.729893179100362 4.4340455367764475 1.02541646520117 1.1955054469420714 0.6147687504898152 0.06060249952760978 0.1411000100896514 6.262075808858009 0.017704621941538642 0.03032993392995392 1.862545199787745e-06 5.729893179100362 0.17008898174090148 CTGGEVGATSALAPK ddPTM_A459_Selumetinib_30min_R2 1 CTGGEVGATSALAPK 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 118.87 0.027351 3422600.0 4156.5 4196.7 6036.0 6182.4 5076.0 5534.9 4243.7 6577.8 4217.6 4680.0 False True 3925.49836978783 4518.5733954826355 5647.6503314998945 5340.346454765133 4438.30749998424 6297.282234180347 4441.040458732024 6596.940308986588 5061.237849590117 4544.876239899699 0.8637195299897676 0.9942126379182453 1.242641170714152 1.175025715305944 0.9765518939812077 1.385578374807258 0.9771532214109384 1.45151153975805 1.1136140089266355 1.0 12.1500252940399 -5.043184131677326 3.5276717250761984 1.1756333864229165 0.8773689247851927 0.28562752324554563 0.15478711486304927 0.2634765129248392 6.5243015577047325 0.037519299053011504 0.14531555280929928 9.053486708216784e-06 5.043184131677326 -0.2982644616377238 CTLPEHES(ph)PSQDISDACEAESTER ddPTM_A459_Selumetinib_30min_R1 2 CTLPEHESPSQDISDACEAESTER 24 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 CTLPEHES(0.998)PS(0.002)QDISDACEAESTER;CTLPEHES(1)PSQDISDACEAESTER 174.55 6.5769e-17 72279000.0 9316.5 7665.9 9874.2 10801.9 9880.0 7608.299999999999 7715.6 7754.0 5100.9 6502.1 True False 9533.556323246701 6768.372864219776 8533.337875098165 8915.550941775802 8986.355744455672 7531.767409783686 7133.606080134805 7548.338731458325 8655.854745004268 7336.707870817359 1.2994324554160828 0.9225354182550726 1.1631017651718893 1.2151977560996372 1.224848515531058 1.0265867937501232 0.9723170399777785 1.0288454800664413 1.179800926711826 1.0 12.840917126491695 -6.780781962404141 24.9755166204578 1.0389882908491852 1.154232374963448 0.2550561179572354 0.10468937689211119 383.1184655591448 494686.8859052713 0.03732534167782126 0.032967229675028915 1.6566014516818756e-07 6.780781962404141 0.11524408411426279 CTLPEHES(ph)PSQDISDACEAESTER ddPTM_A459_Selumetinib_30min_R2 4 CTLPEHESPSQDISDACEAESTER 24 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 CT(0.001)LPEHES(0.996)PS(0.003)QDISDACEAESTER;CTLPEHES(0.993)PS(0.007)QDISDACEAESTER;CTLPEHES(0.986)PS(0.013)QDISDACEAESTER;CT(0.001)LPEHES(0.924)PS(0.074)QDIS(0.001)DACEAESTER 123.12 9.8555e-08 213536000.0 181324.0 162732.0 199535.0 221817.0 237820.0 152919.0 153266.0 155646.0 161096.0 200673.0 True False 171246.7379774834 175213.02113414835 186697.1353372815 191605.14194433152 207942.92546222458 173982.2041895292 160393.17269081727 156098.90409141764 193319.70139832387 194879.0490789305 0.8787334440867707 0.8990859815986841 0.9580154265924444 0.9832003124498367 1.0670358175752537 0.892770182386627 0.8230395901914236 0.8010040321378724 0.9919983821350902 1.0 17.572219473115645 -6.966664216788923 24.998187290840743 0.8832098262832392 0.9579160530666506 0.09433864786943402 0.07624331708012426 338.1208268177407 253552.6812051902 0.02762736996102397 0.02436489424960177 1.0797812534126998e-07 6.966664216788923 0.07470622678341143 CTLPEHESPS(ph)QDISDACEAESTER ddPTM_A459_Selumetinib_30min_R1 1 CTLPEHESPSQDISDACEAESTER 24 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 CTLPEHES(0.277)PS(0.689)QDIS(0.033)DACEAESTER 134.66 6.1227e-08 40884000.0 2803.7 2662.2 2903.8 2678.5 3283.2 2881.6 3053.2 2723.9 1754.4 2330.2 True False 2869.020754949477 2350.508386376798 2509.4799094316527 2210.7502566721114 2986.23513969604 2852.6137202834607 2822.894665854577 2651.653323525835 2977.088663693759 2629.3038680701025 1.0911712372961007 0.8939660474093704 0.9544274969152196 0.840812004850087 1.1357512442591595 1.0849311693962809 1.07362815691842 1.0085001417018173 1.1322725759647283 1.0 11.360465168202142 -6.272108925310506 24.999565290938797 1.073615466103552 0.9421088473134631 0.42790374975832657 0.07213801826369903 656.7421982236556 1538794.51887001 0.02161802505794876 0.02476182483234032 5.344303022310526e-07 6.272108925310506 -0.13150661879008885 CVACQNPDKPS(ph)PSTSVPAPASFK ddPTM_A459_Selumetinib_30min_R2 1 CVACQNPDKPSPSTSVPAPASFK 23 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 CVACQNPDKPS(0.662)PS(0.226)T(0.056)S(0.056)VPAPASFK 85.805 0.0001473 11053000.0 55763.0 44336.0 47430.0 56832.0 52878.0 41805.0 53823.0 55538.0 47917.0 55507.0 True False 52663.91569697553 47736.428637290745 44378.40543787942 49091.383559331654 46234.99290468215 47563.25928199411 56325.8761482512 55699.60638518915 57501.73891284373 53904.368685494155 0.9769878950673541 0.8855762492240592 0.8232803114123437 0.9107125221288846 0.8577225563004162 0.8823637200818112 1.0449222859261253 1.0333041225316884 1.066736153582254 1.0 15.718114580643928 -7.260874112227796 24.940584591092676 1.039015990525311 0.8857827868867346 0.7633053257145302 0.040004621841949535 22.951677487562492 1012705.6544185274 0.016028652561962033 0.011638322486354883 5.484359155247098e-08 7.260874112227796 -0.1532332036385763 CVACQNPDKPSPSTS(ph)VPAPASFK ddPTM_A459_Selumetinib_30min_R2 1 CVACQNPDKPSPSTSVPAPASFK 23 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 CVACQNPDKPS(0.15)PS(0.057)T(0.313)S(0.48)VPAPASFK 80.277 0.00031706 7965300.0 32810.0 27519.0 27892.0 39433.0 39065.0 27626.0 35533.0 36437.0 27152.0 34279.0 True False 30986.551548836473 29629.61881246854 26097.45908651344 34062.15737428081 34157.30545446896 31431.23073614088 37185.35490730374 36543.02563752994 32583.158690267162 33289.27620246192 0.9308268332534322 0.8900649756475411 0.7839599433700932 1.0232171215474408 1.0260753417024682 0.9441848643683147 1.1170370506449667 1.097741669577886 0.9787884390186129 1.0 15.022769882335503 -5.822328022718477 9.969373227842524 1.0313327965488845 0.8706092969565135 0.6023819616189646 0.05889957259334742 0.2629327775447238 41.22752622679161 0.01717982429332772 0.025537369892972377 1.5054695551708332e-06 5.822328022718477 -0.1607234995923711 CVGAELEYDS(ph)EHSDWHGFD ddPTM_A459_Selumetinib_30min_R1 2 CVGAELEYDSEHSDWHGFD 19 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 1 CVGAELEYDS(0.99)EHS(0.01)DWHGFD;CVGAELEYDS(0.939)EHS(0.061)DWHGFD 150.23 1.8268e-05 19105300.0 5831.2 6647.700000000001 7133.700000000001 7713.9 7986.5 6787.299999999999 7910.200000000001 6235.8 3445.3 5362.5 True False 5967.055614459955 5869.3841935681185 6164.982722609194 6366.812172836659 7264.122485131095 6719.025924375323 7313.5272454614405 6070.406327266931 5846.42246524402 6050.829110173343 0.9861550385595028 0.9700132141725571 1.018865780268678 1.0522214488146837 1.2005168800615813 1.1104306206695758 1.2086818371989891 1.0032354602546405 0.9662184072285811 1.0 12.56291712476514 -5.7287600112287675 2.738436807073373 1.0912844743599792 0.9819780017844013 0.21148594303777524 0.07670398065608908 0.3910533079565063 5.967784996794481 0.023719080088307753 0.04352243494843466 1.8674113271240717e-06 5.7287600112287675 -0.1093064725755779 CVGAELEYDS(ph)EHSDWHGFD ddPTM_A459_Selumetinib_30min_R2 1 CVGAELEYDSEHSDWHGFD 19 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 1 CVGAELEYDS(0.724)EHS(0.276)DWHGFD 76.78 0.0056177 2404400.0 22417.0 19283.0 20566.0 25672.0 27240.0 19412.0 18109.0 17899.0 22326.0 22707.0 True False 21171.15288236108 20761.94409538248 19242.80595056774 22175.42931332985 23817.867671310232 22085.82679540892 18951.10438230274 17951.083126661037 26791.82384056074 22051.389910128724 0.9600824695697149 0.9415254176720185 0.8726346062081586 1.0056250151898203 1.0801073205988763 1.0015616650660364 0.8594063439782564 0.8140567646675042 1.2149721151252522 1.0 14.428581971987745 -1.5229154416853306 0.07221148546778416 1.058666187877252 0.7515650812602908 0.03870713987616148 0.10828993838321663 1200.9130675794072 6.410962973889316 4.614589625464845 37.30724383221902 0.029997465209239002 1.5229154416853306 -0.30710110661696133 CVLPEEDS(ph)GELAKPK ddPTM_A459_Selumetinib_30min_R2 1 CVLPEEDSGELAKPK 15 1 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 1 CVLPEEDS(1)GELAKPK 78.501 0.018072 6066600.0 35722.0 26485.0 31052.0 32647.0 28784.0 24951.0 31433.0 29057.0 22419.0 28175.0 True False 33736.71424649608 28516.31433730255 29054.148126861313 28200.422280783743 25167.896587775103 28387.773767373186 32894.69678330787 29141.551059354682 26903.426439197832 27361.514542558572 1.2329987871841455 1.042205258519143 1.0618618381548284 1.0306601353123315 0.9198283431506878 1.0375073983283474 1.2022249986250904 1.0650562129529566 0.9832579405409659 1.0 14.73986046951608 -4.7614350096838685 12.489017890746492 1.0420170270729177 1.2331989737715399 0.42074760145866774 0.06847529915103989 0.06348261643403967 666.4759794555152 0.01829179487123146 0.10227059157225682 1.7320682079740328e-05 4.7614350096838685 0.1911819466986222 CVMDDDNEVRDR ddPTM_A459_Selumetinib_30min_R1 3 CVMDDDNEVRDR 12 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 ;; 155.97 0.0011552 28562000.0 4877.37 4220.44 8190.700000000001 8528.0 6511.15 5587.67 5809.099999999999 5588.3 3377.06 3995.67 False True 4991.003231290055 3726.3089227706746 7078.447928294595 7038.744890386324 5922.2176321369 5531.463112998433 5370.9149100667555 5440.08013064335 5730.6241692964195 4508.553165621693 1.1070077357293038 0.826497722414425 1.5700043158565116 1.5611981564413333 1.3135516904390934 1.2268820860706628 1.1912723911122274 1.206613281645356 1.271056136809737 1.0 12.138448818881155 -6.995267357480687 3.9772011548784043 1.18614914845282 1.282569290762807 0.05212422994515886 0.2103475623550514 0.9568613613397149 34.6074624413396 0.08875796129412232 0.07327082511016923 1.0109569040885049e-07 6.995267357480687 0.09642014230998708 CVPCQCHGHSDR ddPTM_A459_Selumetinib_30min_R2 2 CVPCQCHGHSDR 12 0 O15230 O15230 LAMA5 Laminin subunit alpha-5 0 ; 93.839 0.011139 873120.0 1845.3799999999999 625.58 505.5 1624.61 1558.04 1358.02 3484.8 2257.7 721.44 2893.75 False True 1742.8211672414454 673.5599744432594 472.9766803467856 1403.3353153914315 1362.3050861456754 1545.0749281218436 3646.8501050002014 2264.2695332176454 865.748158717824 2810.1999186345633 0.6201769332084593 0.23968400610107937 0.168307129044612 0.4993720575130087 0.48477159119967533 0.5498096124323332 1.297719098494656 0.8057325452908781 0.3080735121288022 1.0 11.456457052604094 -7.0156930980255385 18.954495680591933 0.8491318243323845 0.39894217049814595 0.4058296871616518 0.25759904915326864 31.296839404518337 37800.59668252833 0.09912200396762831 0.07971389072321822 9.645103713819911e-08 7.0156930980255385 -0.4501896538342386 CVWS(ph)PLASPSTSILK ddPTM_A459_Selumetinib_30min_R2 1 CVWSPLASPSTSILK 15 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 CVWS(1)PLASPSTSILK 100.4 0.007615100000000001 6502200.0 29414.0 25368.0 36379.0 33650.0 39358.0 24659.0 28904.0 29428.0 26969.0 29512.0 True False 27779.28763357134 27313.644029023624 34038.41474646036 29066.81195051223 34413.49617501573 28055.553417885258 30248.09327218943 29513.63060793235 32363.553576819973 28659.91187861539 0.9692733093955838 0.95302609947673 1.1876664133031807 1.0141975339498672 1.200753732976178 0.9789127592823803 1.0554147340124609 1.0297879048942213 1.1292272535202057 1.0 14.806746553263952 -5.2015491161944505 24.997702574098046 1.0738197278205934 0.9611494124209148 0.2810842967867512 0.0725012706107566 306.38000260547284 127879.10203651129 0.017336027376633117 0.045866808504145415 6.2871074654748964e-06 5.2015491161944505 -0.11267031539967864 CVWSPLAS(ph)PSTSILK ddPTM_A459_Selumetinib_30min_R2 2 CVWSPLASPSTSILK 15 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 CVWS(0.002)PLAS(0.838)PS(0.107)T(0.027)S(0.027)ILK;CVWS(0.01)PLAS(0.873)PS(0.091)T(0.02)S(0.006)ILK 161.24 0.00012209 10531800.0 34058.0 28743.0 35302.0 40004.0 40553.0 36106.0 34557.0 35657.0 31400.0 35605.0 True False 32165.192704976318 30947.49567668819 33030.707753911425 34555.38618925087 35458.369591580165 41079.27376236526 36163.96897339643 35760.75596666587 37680.87738930425 34576.991137100194 0.9302484585034908 0.89503148362387 0.955279990180243 0.9993751640284819 1.0254903166960145 1.1880522975374883 1.0458969327320518 1.0342356228994005 1.0897673901091316 1.0 15.077524711790245 -5.945777773855626 1.6692921451232072 1.07202805915958 0.9150742411662616 0.6219222776221478 0.0486357934229501 0.23708927276398306 1.3397191587030968 0.016404220293196298 0.028988100495956882 1.132979954668998e-06 5.945777773855626 -0.15695381799331853 CYYYHAR ddPTM_A459_Selumetinib_30min_R2 1 CYYYHAR 7 0 O43242;O43242-2;H0YGV8 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 96.048 0.04144 0.0 3125.7 2742.7 3349.2 2929.3 3918.4 3733.2 3124.2 2533.1 2405.5 2771.9 False True 2951.9861071684886 2953.056270829514 3133.7161183332432 2530.324286675644 3426.1355610595438 4247.414413384537 3269.4814904848563 2540.470901622721 2886.6672152857127 2691.8680447388856 1.0966310599577829 1.0970286142372792 1.1641418027372947 0.9399882329377288 1.2727724777430103 1.5778687301132328 1.2145771769440503 0.9437575911597664 1.072365794797242 1.0 11.394391975491912 -7.753003122347379 24.87857561821828 1.0060462643547976 1.1977240287402562 0.23369319343826345 0.1570528251806366 277.7641482156874 819134.6902128148 0.08402695787300708 0.04749968536651451 1.7660251238549394e-08 7.753003122347379 0.19167776438545858 DADAGDEDEESEEPR ddPTM_A459_Selumetinib_30min_R1 2 DADAGDEDEESEEPR 15 0 Q9NZT2-2;Q9NZT2;A0A087X028 Q9NZT2-2 OGFR Opioid growth factor receptor 0 ; 355.0 4.608499999999998e-166 5696800.0 1010.34 1107.01 1124.25 1313.75 993.52 1019.26 851.73 928.96 511.81999999999994 909.19 False True 1033.8789562205852 977.4007545650131 971.5830250632055 1084.328224641772 903.656291420203 1009.0071698140346 787.483320368243 904.3209631126548 868.5211581462263 1025.8933927605594 1.0077840090562797 0.9527313085962487 0.9470604176997269 1.0569599456372083 0.8808481444534596 0.9835399827451018 0.767607361471758 0.8814960399337719 0.8465998165843891 1.0 10.00266510359277 -6.816732698079037 1.7997030094714326 0.8690599543360719 0.9800437639998346 0.27264390867537047 0.070729298658369 0.4046654845761438 2.7034473278986857 0.028559713335449925 0.02505322047299541 1.5249910747761542e-07 6.816732698079037 0.11098380966376276 DADAGDEDEESEEPR ddPTM_A459_Selumetinib_30min_R2 2 DADAGDEDEESEEPR 15 0 Q9NZT2-2;Q9NZT2;A0A087X028 Q9NZT2-2 OGFR Opioid growth factor receptor 0 ; 297.18 2.830899999999999e-79 8974900.0 11622.900000000001 11154.7 15286.1 16412.1 14989.5 10835.7 9790.7 12829.900000000001 10514.599999999999 12118.5 False True 10976.945748155176 12010.229621986366 14302.608968247281 14176.743667548333 13106.385002169767 12328.219318308908 10245.986949904007 12867.23288489571 12617.813802470646 11768.60741735567 0.9327310665463276 1.0205310786622352 1.2153187255744984 1.2046237218042708 1.1136733971464814 1.0475512421399964 0.870620166562257 1.0933522063043628 1.072158612739738 1.0 13.522655995513118 -6.926241644314103 5.292698971130864 1.009342648621123 1.1046713735361093 0.15997589625922082 0.09457095895830211 0.39451683293779194 19.963540560955106 0.03703851288168104 0.032440273435762064 1.1851091621310173e-07 6.926241644314103 0.09532872491498634 DADLS(ph)PVNASIIK ddPTM_A459_Selumetinib_30min_R1 4 DADLSPVNASIIK 13 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 DADLS(1)PVNASIIK;DADLS(0.998)PVNAS(0.002)IIK;DADLS(1)PVNASIIK;DADLS(0.999)PVNAS(0.001)IIK 188.19 0.00014662 43505700.0 14806.7 17052.600000000002 10245.3 11262.0 12893.7 12991.2 14717.500000000002 14741.0 7828.9 13157.7 True False 15151.66730117716 15056.073664461339 8854.044533404543 9295.303113922459 11727.467111567625 12860.520323065835 13607.347125872775 14350.02079448377 13285.071499767475 14846.61896185134 1.0205466537606742 1.0141079058570976 0.5963677357218619 0.6260888851399036 0.7899082708124703 0.8662255262367262 0.9165283463418239 0.9665514304203813 0.8948213417414235 1.0 13.857846801326847 -7.1146949614882455 2.4301928336304006 0.9447684717717044 0.7999730356182029 0.18827021435090652 0.1315596327932004 0.578001747352322 6.680364492108567 0.06520817254435259 0.04796715249839374 7.679006558492941e-08 7.1146949614882455 -0.14479543615350154 DADLS(ph)PVNASIIK ddPTM_A459_Selumetinib_30min_R2 3 DADLSPVNASIIK 13 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 DADLS(1)PVNASIIK;DADLS(1)PVNASIIK;DADLS(0.998)PVNAS(0.002)IIK 169.37 0.00025568 11612000.0 78809.0 56360.6 68234.0 72804.0 74807.0 63442.0 73493.0 70477.0 62720.0 67705.0 True False 74429.11127742312 60683.27679210777 63843.89872756189 62887.96960609483 65409.07587693477 72180.55963086392 76910.57012361684 70682.07640190463 75265.75254322178 65750.18073128411 1.1319985808344637 0.9229370340458167 0.9710071975085051 0.9564683915183912 0.9948121077302675 1.097800170707671 1.1697392960476318 1.0750096139016985 1.1447231278470105 1.0 16.004707239578252 -6.764891516098001 5.226825723131962 1.1075682503342663 0.9871666776673161 0.3640601200204674 0.06647988441499048 0.16616256504627777 13.218887734707018 0.02216577338951313 0.02068335664024515 1.71833756296167e-07 6.764891516098001 -0.12040157266695017 DAEDALHNLDR ddPTM_A459_Selumetinib_30min_R1 2 DAEDALHNLDR 11 0 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 0 ; 170.4 0.00051338 12031300.0 13454.5 18387.2 8691.0 9333.0 11943.2 11147.599999999999 13140.9 13723.5 7198.2 12720.3 False True 13767.963672100339 16234.418076022623 7510.8099362457815 7703.166752107825 10862.939668743225 11035.465265210969 12149.671333200706 13359.508199789556 12214.81966427292 14353.07441121454 0.9592344662648 1.1310760058025007 0.5232892773395874 0.5366910622360518 0.7568371317197133 0.7688572461234221 0.8464856368129575 0.9307767671956972 0.8510246177452456 1.0 13.809072173087781 -7.508662414921158 2.6306345204372743 0.919379568861727 0.7714706962511915 0.1285365945616047 0.17119610609272237 0.7064613623690188 9.780988798365003 0.10156108588069133 0.0563891542120012 3.0998279161477604e-08 7.508662414921158 -0.14790887261053554 DAEDALHNLDR ddPTM_A459_Selumetinib_30min_R2 4 DAEDALHNLDR 11 0 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 0 ;;; 194.48 2.878e-05 19971500.0 254174.0 145028.0 200264.0 220042.0 241795.0 212535.0 249725.0 259772.0 218456.0 188649.0 False True 240048.02661913927 156151.1812614803 187379.23227095688 190071.90000637792 211418.5504252735 241809.76704936303 261337.70732069982 260527.89351243014 262153.3041706316 183202.2132010343 1.3102899928164409 0.8523433125239053 1.0228000469914575 1.0374978374186195 1.154017447339877 1.3199063637076076 1.426498636421628 1.4220783087731785 1.4309505305100299 1.0 17.483077406664627 -6.6348857057165445 2.4500204901340923 1.3578048379159917 1.039746317747072 0.37365879343171793 0.15852672317758368 0.25655313768902305 3.134867371904745 0.055421136507412636 0.05538335986955528 2.3180046043373685e-07 6.6348857057165445 -0.31805852016891967 DAEDALHNLDRK ddPTM_A459_Selumetinib_30min_R2 2 DAEDALHNLDRK 12 1 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 0 ; 86.014 0.02056 7498100.0 109936.0 94223.0 99216.0 121894.0 115955.0 83645.0 80246.0 85515.0 63124.0 103811.0 False True 103826.19722867689 101449.60112530316 92832.55057821312 105291.82692112132 101387.69624914753 95166.33949628982 83977.59800443235 85763.83449222971 75750.56383192493 100813.70669662966 1.029881755475101 1.0063076187704025 0.9208326290150846 1.0444197557180126 1.0056935665925382 0.9439821490014846 0.8329978209921315 0.8507160117652625 0.7513915152418196 1.0 16.621332276359077 -7.082559474501272 3.1010098062838223 0.8462120908685823 0.9990042171985 0.5116411845650723 0.06505213030682067 0.1979585444393069 3.6827199842839047 0.025568146456187775 0.019669436222461284 8.268762641612577e-08 7.082559474501272 0.15279212632991768 DAEDAMDAMDGAVLDGR ddPTM_A459_Selumetinib_30min_R1 2 DAEDAMDAMDGAVLDGR 17 0 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 0 ; 234.85 6.6188e-16 15952500.0 4125.6 4386.8 5207.3 5888.6 4434.9 4575.4 4880.6 4774.9 3014.7 4023.3 False True 4221.718452979831 3873.191416632008 4500.177261651437 4860.266552712113 4033.7640780451898 4529.375630130815 4512.452412606399 4648.254140938912 5115.725715023697 4539.729745260685 0.929949289908095 0.853176650146516 0.9912874805707235 1.0706070240824481 0.8885471832891142 0.9977192221319606 0.9939914192727523 1.0239054749440806 1.1268789117599636 1.0 12.148390699628193 -4.322205990092634 0.31783567720792605 1.0458459275438299 0.725281697223536 0.32925845987029445 0.0629727717501646 11.874799254073247 0.7765879426593096 0.06780958315911889 1.5537586395158343 4.7620506454188084e-05 4.322205990092634 -0.3205642303202939 DAEDAMDAMDGAVLDGR ddPTM_A459_Selumetinib_30min_R2 3 DAEDAMDAMDGAVLDGR 17 0 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 0 ;; 155.98 0.00067255 14596400.0 26213.3 26881.3 40191.3 41961.2 54045.0 35949.7 29543.8 34682.3 34223.8 38920.2 False True 24756.46972615407 28943.00927299719 37605.43551497877 36246.012172892544 47255.38393156979 40901.44485611541 30917.64523992911 34783.219751036144 41069.51629286851 37796.47269917611 0.6549941822135618 0.7657595327308966 0.9949456345908833 0.9589786978635876 1.2502590997757277 1.0821497863478404 0.8180034546081612 0.9202768741908117 1.086596535601158 1.0 15.205963982862139 -5.140911192699058 2.217238731161821 1.0172674553577088 0.6493921906952203 0.5689328195352803 0.1078944818323712 0.28772451067553323 2.4917896525119416 0.032427061759301525 0.1525790824451858 7.229176152859244e-06 5.140911192699058 -0.36787526466248854 DAEDDGEEEDD ddPTM_A459_Selumetinib_30min_R1 2 DAEDDGEEEDD 11 0 H0YCE2;Q5TB25;Q5TB19;Q9BTT0-3;Q9BTT0-2;Q9BTT0 H0YCE2 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 ; 198.07 0.00027512 5232000.0 7001.799999999999 8741.1 8464.5 8784.4 7504.9 6663.7 8503.9 7422.0 3720.4 6390.2 False True 7164.928316868866 7717.687948372855 7315.06739217034 7250.369443610414 6826.083120097714 6596.669228155501 7862.443976470833 7225.14444994631 6313.247072734985 7210.444415819055 0.9936874766206739 1.070348442245939 1.0145099206536772 1.005537110542558 0.9466938133691055 0.9148769268206287 1.090424323807469 1.0020387140208729 0.8755697580698768 1.0 12.815872467392955 -5.892732707297846 2.8406351444737297 0.9749955339929814 1.0318000608155318 0.15562123178937326 0.05682050219764859 0.5205358757709373 8.468989137552734 0.017472589367782967 0.028110285629078382 1.2801689598995287e-06 5.892732707297846 0.05680452682255033 DAEDDGEEEDD ddPTM_A459_Selumetinib_30min_R2 2 DAEDDGEEEDD 11 0 H0YCE2;Q5TB25;Q5TB19;Q9BTT0-3;Q9BTT0-2;Q9BTT0 H0YCE2 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 ; 198.07 0.00027512 20011800.0 205016.0 171840.0 176905.0 205724.0 202284.0 147560.0 163794.0 169010.0 140229.0 170720.0 False True 193622.0314640739 185019.57544731215 165523.12489960084 177704.0363063057 176871.27547809546 167885.05058368726 171410.74555165385 169501.79111888816 168278.7183256287 165790.8700161702 1.1678690837751755 1.1159816908450175 0.9983850430572971 1.0718565882968922 1.0668336287809126 1.0126314589416945 1.0338973764655166 1.0223831451174363 1.015005942783314 1.0 17.33900503528092 -1.5228787458513888 0.6628313251106339 1.0243954206282682 15.734928584783638 0.7450430564173184 0.026628922468543665 117.92623633849327 0.7246877539566559 0.011113005529189993 2552.705483079183 0.029999999960553175 1.5228787458513888 14.71053316415537 DAEFYEHR ddPTM_A459_Selumetinib_30min_R1 1 DAEFYEHR 8 0 O95340;O95340-2 O95340 PAPSS2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 112.41 0.015714 1890400.0 1087.8 1196.8 1086.6 1119.5 1194.8 810.46 1183.0 1085.3 801.76 838.37 False True 1113.1436235096617 1056.6780996227742 939.0456882665596 924.0003406176701 1086.7305509590726 802.3075082388025 1093.7653575612362 1056.5143184487642 1360.5281617664778 945.9829559153426 1.1767057921594082 1.1170160022601272 0.9926666039748355 0.9767621444337737 1.1487844935932712 0.8481204690019829 1.1562209981921903 1.116842868935699 1.4382163581901082 1.0 9.88567038006463 -7.735634937525174 2.6670466233637744 1.221590012837352 1.0458640492924278 0.17021871938096877 0.13708024810877115 0.4118900894142209 5.893938176435089 0.08095489783454478 0.03710714470032533 1.8380827633815033e-08 7.735634937525174 -0.1757259635449242 DAEFYEHR ddPTM_A459_Selumetinib_30min_R2 1 DAEFYEHR 8 0 O95340;O95340-2 O95340 PAPSS2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 150.36 0.0018196 3488900.0 43296.0 36651.0 43364.0 51085.0 45763.0 36321.0 45199.0 40787.0 39080.0 45492.0 False True 40889.78164762033 39462.01384846047 40574.00745115333 44127.13487345964 40013.84281358918 41323.88806078959 47300.843060119405 40905.683417348686 46897.09198643347 44178.52775758912 0.925557815597333 0.893239676636385 0.9184101306812652 0.998836699936868 0.9057305628912787 0.9353840011948078 1.070674951407676 0.9259177590027722 1.0615358719910566 1.0 15.431057721460933 -7.122258014349803 8.8301285785308 1.0082398619134514 0.9288766572146113 0.457657722293225 0.04517432242089337 0.31305098135788695 21.252978185266326 0.016623244678747796 0.012875073224909633 7.54643760606604e-08 7.122258014349803 -0.07936320469884006 DAELQDQEFGKRDS(ph)LGTYSSR ddPTM_A459_Selumetinib_30min_R1 2 DAELQDQEFGKRDSLGTYSSR 21 2 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DAELQDQEFGKRDS(0.999)LGT(0.001)YSSR;DAELQDQEFGKRDS(0.98)LGT(0.016)Y(0.001)S(0.002)SR 101.23 0.00028127 187719000.0 3441.8 2970.0 5596.0 5475.9 4174.1 3718.9 3034.3999999999996 3466.9 1934.46 2371.4 True False 3521.9872434230147 2622.2710192844593 4836.093936627708 4519.636860373647 3796.5533919972113 3681.491242491032 2805.5127649905435 3374.9465499216985 3282.637332631684 2675.792289392086 1.3162408970926425 0.9799979728173198 1.8073502774486363 1.6890835952743048 1.4188520562856362 1.3758509048276806 1.0484792770024496 1.261288689447735 1.2267907885247205 1.0 11.38575041458224 -7.098056981478645 4.562588138581433 1.1571029779951034 1.4467302576840992 0.30813345850324114 0.21847932957117508 0.339279404855458 11.769476431896619 0.09248771751198913 0.07155561320917692 7.978899934801043e-08 7.098056981478645 0.2896272796889958 DAELQDQEFGKRDS(ph)LGTYSSR ddPTM_A459_Selumetinib_30min_R2 2 DAELQDQEFGKRDSLGTYSSR 21 2 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DAELQDQEFGKRDS(0.879)LGT(0.087)Y(0.029)S(0.004)S(0.001)R;DAELQDQEFGKRDS(0.603)LGT(0.293)Y(0.06)S(0.04)S(0.004)R 65.765 0.0038444 125006000.0 137842.0 218684.0 191837.0 208888.0 188128.0 109947.0 91467.0 90091.0 64050.0 195787.0 True False 130181.29346524572 235456.35962011243 179494.41627633292 180437.094048101 164493.67875434124 125091.20125050616 95720.39673842209 90353.14989463205 76861.7897065268 190134.1205942823 0.6846813873193915 1.2383698353781591 0.9440410575193238 0.948999019661109 0.8651454996094365 0.6579103259295159 0.5034361872516036 0.4752074462606957 0.40425037582043644 1.0 17.536657929069243 -6.739416302911083 2.0881351879748125 0.5516725670399558 0.9734684391737257 0.40959020867469664 0.1966786510255676 0.26590101138597266 2.385315961864167 0.07369271322954443 0.06879874388093617 1.822148203055006e-07 6.739416302911083 0.4217958721337699 DAENHEAQLK ddPTM_A459_Selumetinib_30min_R2 1 DAENHEAQLK 10 0 A0A0A0MSS4;A0A0A0MSU9;Q9Y266 A0A0A0MSS4 NUDC Nuclear migration protein nudC 0 97.472 0.028935 5323400.0 48526.0 46197.0 46631.0 52990.0 53207.0 42139.0 49472.0 45300.0 34037.0 48721.0 False True 45829.119184969146 49740.161353232616 43630.812227994 45772.67058715134 46522.66098338487 47943.26475024401 51772.54602690829 45431.81550018129 40845.351073240396 47314.298137639606 0.9686103564645512 1.051271250152249 0.9221485670371742 0.9674173006645138 0.9832685427996454 1.0132933729836742 1.0942262289572473 0.9602132397276172 0.86327712089101 1.0 15.52998860402611 -7.997991673253514 24.998555515454306 0.9250074180787684 0.9997337625183306 0.20766934307257756 0.05432025860101019 84.01255811481383 1045747.1555070973 0.030064213411746973 0.014286212286389472 1.0046350520041213e-08 7.997991673253514 0.07472634443956216 DAEPPS(ph)PTPAGPPR ddPTM_A459_Selumetinib_30min_R1 2 DAEPPSPTPAGPPR 14 0 O43306-2;O43306 O43306-2 ADCY6 Adenylate cyclase type 6 1 DAEPPS(0.772)PT(0.228)PAGPPR;DAEPPS(0.976)PT(0.024)PAGPPR 201.3 6.0184e-05 16339100.0 4873.1 3551.7 6077.0 3518.6 6161.1 4613.4 4845.4 6236.0 2551.45 4555.0 True False 4986.633748598026 3135.8653128594647 5251.77677857158 2904.1425623022183 5603.8295928305515 4566.993384632049 4479.907576946081 6070.601022617245 4329.624299465026 5139.678619457263 0.9702228714690728 0.6101286763316349 1.021810344072866 0.5650436101798303 1.090307392298062 0.888575672288691 0.8716318487281501 1.181124632897433 0.8423920287689549 1.0 12.327462436180282 -6.288108165001858 24.998291836065306 0.9781713351713682 0.795253877089883 0.24341567311186074 0.16163701353443058 1058.4987770176256 992192.7838467498 0.046705863700378214 0.052974532255832894 5.15100338167099e-07 6.288108165001858 -0.18291745808148518 DAEPPS(ph)PTPAGPPR ddPTM_A459_Selumetinib_30min_R2 2 DAEPPSPTPAGPPR 14 0 O43306-2;O43306 O43306-2 ADCY6 Adenylate cyclase type 6 1 DAEPPS(0.755)PT(0.245)PAGPPR;DAEPPS(0.931)PT(0.069)PAGPPR 95.195 0.012668 20359000.0 86134.0 25425.0 59597.0 74912.0 47572.0 40202.0 92576.0 63461.0 51386.0 47238.0 True False 81347.01710172152 27375.01574573976 55762.59390430737 64708.85636959209 41595.58006092404 45739.46058257931 96880.96743586383 63645.66100346592 61664.63584480218 45874.11620093633 1.7732661430556595 0.5967420849228483 1.2155568002674502 1.4105744530566307 0.9067331102081273 0.9970646711150313 2.1118873879010316 1.3873980857677395 1.3442141440872826 1.0 15.485392743177046 DAEPQPGS(ph)PAAESLEEPDAAAGLSSTK ddPTM_A459_Selumetinib_30min_R1 2 DAEPQPGSPAAESLEEPDAAAGLSSTK 27 0 Q9H9J4-2;Q9H9J4;C9JPC9 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 DAEPQPGS(0.633)PAAES(0.366)LEEPDAAAGLSSTK;DAEPQPGS(0.978)PAAES(0.022)LEEPDAAAGLSSTK 105.75 1.5095999999999998e-09 12118900.0 6131.98 8122.63 5521.3099999999995 4687.05 5662.509999999999 5765.259999999999 7547.14 6443.650000000001 3575.5299999999997 6771.48 True False 6274.843203243957 7171.628703491761 4771.546428384905 3868.5447043251897 5150.336970297335 5707.266718837253 6977.85315356273 6272.7434700749845 6067.4132636211525 7640.665417800765 0.821243027946912 0.9386131064951136 0.6244935705820126 0.5063099210328574 0.6740691665804903 0.746959382037696 0.9132520234829477 0.8209682176975218 0.7940948768003447 1.0 12.899482571242165 -7.120430667016005 4.780742146863607 0.8663420347875221 0.7092025340903753 0.30959558366837503 0.11929613052795288 0.35136371928255183 12.222962249075028 0.05188524822349294 0.03998828480742869 7.578257063663816e-08 7.120430667016005 -0.15713950069714688 DAEPQPGS(ph)PAAESLEEPDAAAGLSSTK ddPTM_A459_Selumetinib_30min_R2 3 DAEPQPGSPAAESLEEPDAAAGLSSTK 27 0 Q9H9J4-2;Q9H9J4;C9JPC9 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 DAEPQPGS(1)PAAESLEEPDAAAGLSSTK;DAEPQPGS(0.998)PAAES(0.002)LEEPDAAAGLSSTK;DAEPQPGS(0.994)PAAES(0.006)LEEPDAAAGLSSTK 146.92 6.982100000000002e-14 14342100.0 155119.0 115009.0 132451.0 158860.0 164512.0 132232.0 154255.0 161138.0 148358.0 127844.0 True False 146498.10697055655 123829.82048777903 123929.24686174473 137222.99395121468 143844.53180405984 150445.75771741784 161428.16315048383 161606.88490216815 178033.74546886637 124152.81154139675 1.1799821941342756 0.9973984394746468 0.9981992781566814 1.105274961134971 1.1586087340124167 1.211778902544258 1.3002376760244228 1.301677206466508 1.433988834070857 1.0 16.921757407324115 -6.606594850796699 1.506643884220342 1.2823378088693604 1.0554151911160266 0.35427542860983674 0.11317086514903359 0.3697711678756113 1.7335823544752382 0.04572887046784873 0.047141654436743174 2.474031068915489e-07 6.606594850796699 -0.2269226177533339 DAGDPS(ph)PPNK ddPTM_A459_Selumetinib_30min_R1 4 DAGDPSPPNK 10 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2;A0A494C0S5;E9PMZ7;C9JMU2;A0A494C0B7;A0A494C0C1;C9JVK6;C9JD58;J3QTA0;Q9BTA9-3 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 DAGDPS(1)PPNK;DAGDPS(1)PPNK;DAGDPS(1)PPNK;DAGDPS(1)PPNK 114.24 0.007138800000000002 160945000.0 33546.3 39598.8 38374.3 40072.1 31100.600000000002 34063.8 34402.8 32940.9 19431.0 30551.600000000002 True False 34327.86352026308 34962.55408701734 33163.280834941506 33074.25998147861 28287.556221256906 33721.14909945577 31807.769098146804 32067.20032487689 32972.98781591054 34473.195457784954 0.995784204638069 1.0141953370650436 0.9620019378694518 0.9594196169595172 0.8205666995940997 0.9781846055074841 0.922681192612325 0.9302067852730859 0.9564819094385512 1.0 15.073187413602186 -5.5595850406396465 2.3971131026510766 0.931094140890518 1.0043554348991668 0.24405148908024177 0.045612124149324154 0.37233917722063387 4.2668423569722576 0.012839535317243274 0.02894758439678549 2.7568615693031925e-06 5.5595850406396465 0.07326129400864878 DAGDPS(ph)PPNK ddPTM_A459_Selumetinib_30min_R2 3 DAGDPSPPNK 10 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2;A0A494C0S5;E9PMZ7;C9JMU2;A0A494C0B7;A0A494C0C1;C9JVK6;C9JD58;J3QTA0;Q9BTA9-3 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 DAGDPS(1)PPNK;DAGDPS(1)PPNK;DAGDPS(1)PPNK 130.44 0.0037742 19397000.0 580492.0 541471.0 580940.0 576602.0 588410.0 459467.0 498521.0 525076.0 415074.0 495161.0 True False 548230.5785335934 583000.0845963213 543562.9528796473 498067.81290607044 514488.6753478581 522754.40862384904 521703.21430062136 526603.8842289892 498100.39813656366 480864.41534721793 1.1400938830912086 1.2124001402252946 1.1303871435093749 1.035775983852809 1.069924616851428 1.0871139388560986 1.0849278874668131 1.09511926318928 1.0358437477160796 1.0 18.875270643109175 -1.5228787452803438 0.2119358893813943 1.0232872642338635 1.8379038384220618 0.5940721981742907 0.0369046773552709 39.36786721537259 0.4927149788351908 0.06633508342686824 10.83986782288393 0.029999999999999565 1.5228787452803438 0.8146165741881983 DAGGPRPES(ph)PVPAGR ddPTM_A459_Selumetinib_30min_R1 1 DAGGPRPESPVPAGR 15 1 E9PS47;E9PLE4;Q9BVG9 E9PS47 PTDSS2 Phosphatidylserine synthase 2 1 DAGGPRPES(1)PVPAGR 114.06 0.01238 13954000.0 1879.3 2560.7 2538.2 2055.4 2937.8 2490.7 2715.7 2905.4 1464.9 2788.2 True False 1923.0840335187606 2260.892053562868 2193.526381334605 1696.4629746364967 2672.076508710716 2465.6458193746575 2510.8525625773877 2828.3393539307467 2485.8283079371777 3146.092629367892 0.611261097517381 0.7186349290729952 0.6972224405787203 0.5392285525227359 0.8493317977250991 0.7837168544748319 0.7980860255477805 0.8990006611785655 0.7901319512123285 1.0 11.619345432835388 -7.297721448557378 0.2570643679427086 1.0242479677064906 0.562018217072773 0.6585714055446836 0.07473516657685385 1.5202155432348783 0.3085040321229375 0.159294146942485 0.256866634805523 5.0382365182443255e-08 7.297721448557378 -0.46222975063371763 DAGGPRPES(ph)PVPAGR ddPTM_A459_Selumetinib_30min_R2 1 DAGGPRPESPVPAGR 15 1 E9PS47;E9PLE4;Q9BVG9 E9PS47 PTDSS2 Phosphatidylserine synthase 2 1 DAGGPRPES(1)PVPAGR 116.0 0.010959 12479000.0 44959.0 20516.0 39315.0 41669.0 32997.0 29499.0 46979.0 43873.0 34139.0 35565.0 True False 42460.35876513682 22089.511230662596 36785.515702935474 35993.61031696566 28851.62186307722 33562.219484739755 49163.61658712246 44000.663166433835 40967.753923358534 34538.146041032654 1.2293757376175396 0.6395685282128173 1.0650692037503362 1.0421407760047068 0.8353552570193078 0.9717435164257671 1.4234584719374972 1.2739729316726887 1.1861596124669591 1.0 15.07590302265966 -7.1611462277198 7.872089642211487 1.243148199155287 0.9500047298744387 0.3377106634480507 0.1747338602737337 0.29243695190152863 20.45858882110171 0.06379707528142264 0.04937572358238197 6.900074379992773e-08 7.1611462277198 -0.29314346928084833 DAGT(ph)IAGLNVLR ddPTM_A459_Selumetinib_30min_R1 3 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 DAGT(1)IAGLNVLR;DAGT(1)IAGLNVLR;DAGT(1)IAGLNVLR 115.24 0.012406 14286300.0 3519.8 4661.0 4238.4 4662.0 4383.599999999999 4247.0 3635.2999999999997 4240.700000000001 2467.8 3326.9 True False 3601.804491661433 4115.287953159888 3662.8485598647017 3847.869216578453 3987.104153987438 4204.27903596747 3361.08639420318 4128.222860265067 4187.676359019301 3753.9400217502466 0.9594731058015462 1.0962583124173535 0.9757344386543837 1.025021495890713 1.0621118427269065 1.1199643605406504 0.8953489865925185 1.0997040006889385 1.1155416268656386 1.0 11.87418988448065 -6.099105790210657 6.059871637152142 1.0494364797001048 1.0161787975781287 0.055955228425716985 0.0703493973057142 0.8837090045524116 44.85568079844048 0.02079475947916562 0.027122769509905113 7.959654368139707e-07 6.099105790210657 -0.033257682121976107 DAGT(ph)IAGLNVLR ddPTM_A459_Selumetinib_30min_R2 2 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 DAGT(1)IAGLNVLR;DAGT(1)IAGLNVLR 110.51 0.016811000000000003 6617100.0 20253.9 18188.3 18054.2 16151.6 18789.4 14877.6 14861.400000000001 11743.7 11709.4 17205.800000000003 True False 19128.269320785705 19583.284125397764 16892.612427926673 13951.72421693591 16428.90759263276 16926.85435459386 15552.484547305436 11777.872222725802 14051.607187971944 16709.023847962868 1.1447867628196478 1.1720184436618253 1.0109873911028135 0.8349814054898771 0.9832356301673327 1.013036698529672 0.9307835507818468 0.7048809272099841 0.8409591916217828 1.0 14.028339832228088 -5.461042323794831 3.329623052007588 0.8983693871602932 1.1571378500574385 0.5730178487591536 0.08821735741702233 0.18648114545321748 4.035199245835977 0.026544878402227766 0.059129865998676846 3.459056662445834e-06 5.461042323794831 0.2587684628971453 DAGTELT(ph)GHLVPHHDGLR ddPTM_A459_Selumetinib_30min_R2 1 DAGTELTGHLVPHHDGLR 18 0 Q9HCU4 Q9HCU4 CELSR2 Cadherin EGF LAG seven-pass G-type receptor 2 1 DAGTELT(1)GHLVPHHDGLR 74.325 0.022186 5807600.0 15021.0 12947.0 46132.0 59174.0 74803.0 47501.0 22716.0 41309.0 61576.0 44158.0 True False 14186.192953827263 13939.99326883353 43163.917344723835 51114.39911915631 65405.57839269522 54043.83157885426 23772.33901090007 41429.20235092689 73892.92057719096 42883.043803737375 0.33081124135574763 0.3250700517582808 1.0065497575748572 1.1919489519701854 1.525208394535533 1.2602610912181609 0.5543528840839475 0.9660975219141562 1.7231267657999358 1.0 15.388119690305697 -5.3178557723829 3.419134204114639 1.1622290302848879 0.3073614222632001 0.5539781935494847 0.29905268360611925 0.18397760365912333 4.2859922133660895 0.08522434166701479 0.21513141639611955 4.809990599659773e-06 5.3178557723829 -0.8548676080216877 DAGTIAGLNVLR ddPTM_A459_Selumetinib_30min_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 133.75 0.023506 18407000.0 1138.2 878.28 1027.7 971.65 1017.0 887.35 679.15 1128.4 637.43 836.68 False True 1164.7178454483333 775.4505692987052 888.143984752018 801.9695676294407 925.0125295659333 878.4240646493371 627.9211687131982 1098.471166440234 1081.672153954807 944.0760279533484 1.233711916161362 0.8213857214230887 0.9407547257368828 0.8494756183652087 0.9798072424010779 0.9304590294000606 0.6651171623057321 1.1635410008467189 1.1457468698784268 1.0 9.882759236580682 -7.850931645647642 22.796171579023994 1.115993561514026 0.9146111225251574 0.2658261065342665 0.1409962862659564 13.174748543887317 3350.298115032841 0.07397711576022764 0.035537297549275884 1.4095106262561341e-08 7.850931645647642 -0.20138243898886854 DAGTIAGLNVLR ddPTM_A459_Selumetinib_30min_R2 2 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ; 143.5 0.011363 39013000.0 78694.0 66565.0 83980.0 84982.0 88013.0 62687.0 53176.0 76876.0 64285.0 71211.0 False True 74320.50251704169 71670.32145979033 78576.81823051065 73407.30499787325 76956.02009379692 71321.56523407172 55648.78936624504 77099.69643249315 77143.79627297535 69154.95340160189 1.0746952873417763 1.036372926803681 1.1362428049686244 1.0614901953816205 1.1128056098439123 1.0313298140754679 0.8046970842866045 1.1148832099524952 1.1155209060004718 1.0 16.07754497137332 -6.985688818138822 18.852522150567562 1.004015686688004 1.0821537458589403 0.15399375914078717 0.08420968476585261 25.607088489511394 33729.153144993965 0.03096436328347787 0.02726194158955027 1.033501667943214e-07 6.985688818138822 0.07813805917093641 DAHDVS(ph)PTS(ph)TDTEAQLTVER ddPTM_A459_Selumetinib_30min_R2 1 DAHDVSPTSTDTEAQLTVER 20 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 2 DAHDVS(0.999)PT(0.002)S(0.551)T(0.386)DT(0.062)EAQLTVER 139.39 0.0013964 4208800.0 36459.0 20068.0 32062.0 24569.0 25468.0 21271.0 21253.0 23224.0 13497.0 18282.0 True False 34432.75473694086 21607.151071209646 29999.165826466167 21222.65981611099 22268.48215319123 24200.88717108712 22241.306612020573 23291.57799505982 16196.777137689152 17754.151157659464 1.9394199379724184 1.2170196637020254 1.6896986828640344 1.1953632492846693 1.2542690413889037 1.3631114749547695 1.252738382957006 1.311894766932375 0.9122811332324141 1.0 14.115868764976774 -1.5228787452803376 0.21785924814461474 1.0239943861325909 4.67086525239534 0.5587139827922781 0.19086034235486174 40.974941625909345 0.5209982005497079 0.28998382838312586 52.37101929672457 0.029999999999999995 1.5228787452803376 3.6468708662627494 DAHDVS(ph)PTSTDTEAQLTVER ddPTM_A459_Selumetinib_30min_R1 8 DAHDVSPTSTDTEAQLTVER 20 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 DAHDVS(0.986)PT(0.01)S(0.003)T(0.001)DT(0.001)EAQLTVER;DAHDVS(0.998)PT(0.001)S(0.001)TDTEAQLTVER;DAHDVS(0.982)PT(0.018)STDTEAQLTVER;DAHDVS(0.975)PT(0.005)S(0.018)T(0.001)DTEAQLTVER;DAHDVS(1)PTSTDTEAQLTVER;DAHDVS(0.987)PT(0.013)STDTEAQLTVER;DAHDVS(0.997)PT(0.003)STDTEAQLTVER;DAHDVS(1)PTSTDTEAQLTVER 201.14 8.839399999999997e-16 1467434100.0 23015.62 25493.11 27690.5 29200.96 29834.35 22302.789999999997 22483.790000000005 22731.8 13731.679999999998 20134.239999999998 True False 23551.83916539938 22508.36482977468 23930.28219302885 24101.560505907055 27135.838310182316 22078.444181913095 20787.81961849682 22128.878820707294 23301.658037773785 22718.66582810564 1.0366735152318234 0.9907432505094206 1.0533313168163376 1.0608704176673356 1.194429220249902 0.9718195755403684 0.9150105809813822 0.9740395403558992 1.0256613752796573 1.0 14.47159049345488 DAHDVS(ph)PTSTDTEAQLTVER ddPTM_A459_Selumetinib_30min_R2 6 DAHDVSPTSTDTEAQLTVER 20 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 DAHDVS(1)PTSTDTEAQLTVER;DAHDVS(0.997)PT(0.002)S(0.001)TDTEAQLTVER;DAHDVS(0.961)PT(0.028)S(0.008)T(0.002)DT(0.001)EAQLTVER;DAHDVS(0.987)PT(0.013)STDTEAQLTVER;DAHDVS(0.993)PT(0.006)S(0.001)TDTEAQLTVER;DAHDVS(0.999)PT(0.001)STDTEAQLTVER 235.54 6.392e-25 1158117200.0 805788.0 729364.0 884538.0 796948.0 930260.0 613828.0 587706.0 613295.0 626192.0 688235.0 True False 761005.5287849385 785303.873525101 827627.7880921577 688402.3075880173 813392.4221700827 698377.2352242057 615035.4935173456 615079.5869135477 751447.8972663456 668363.86730072 1.138609619724604 1.1749645843313754 1.2382892442026334 1.0299813339225314 1.2169904178917998 1.044905730832965 0.9202105673384943 0.9202765394808546 1.1243095775077907 1.0 19.350274215802536 -6.9447433541808445 5.386901871884478 0.9839897276889134 1.1569369333888693 0.5376144940357093 0.07430544142664014 0.14855807646662184 9.088912174822607 0.026339586813053414 0.02296481950579811 1.1356817472178183e-07 6.9447433541808445 0.17294720569995592 DAHDVSPT(ph)STDTEAQLTVER ddPTM_A459_Selumetinib_30min_R2 1 DAHDVSPTSTDTEAQLTVER 20 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 DAHDVS(0.161)PT(0.503)S(0.166)T(0.166)DT(0.004)EAQLTVER 77.633 0.012182 79871000.0 15002.0 14650.0 13764.0 18419.0 20614.0 11302.0 11978.0 14557.0 13717.0 14207.0 True False 14168.24889776424 15773.607892825456 12878.439225110109 15910.300425452737 18024.285028501807 12858.74791065896 12535.000733956724 14599.358459958914 16460.78328500275 13796.806995780984 1.0269223090601212 1.1432795934341164 0.9334362094829833 1.1531871418015816 1.3064098841140253 0.9320089724086972 0.9085436027183597 1.0581693622606554 1.1930864358714595 1.0 13.752046801309596 DAHDVSPTS(ph)TDTEAQLTVER ddPTM_A459_Selumetinib_30min_R2 1 DAHDVSPTSTDTEAQLTVER 20 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 DAHDVS(0.08)PT(0.153)S(0.733)T(0.034)DT(0.001)EAQLTVER 103.94 0.00036526 471260000.0 266700.0 238510.0 308480.0 334950.0 350210.0 254400.0 268070.0 223560.0 227370.0 299810.0 True False 251877.88168469016 256802.9500694749 288632.7326476287 289329.2321790214 306213.48888287676 289441.29078673106 280535.786170628 224210.52258764964 272850.3532486026 291153.7063000697 0.865102783287598 0.8820184820343928 0.9913414337585563 0.9937336393747709 1.05172450927788 0.9941185172083168 0.9635315646008001 0.7700761410077093 0.9371350848180403 1.0 18.15142145840514 -10.186037621398686 9.501234949347634 0.9999999916588803 0.9409673749591424 0.05313705435368632 0.07705326883078695 0.0 0.0 0.08218470461536033 0.01993271870231282 6.515719482370322e-11 10.186037621398686 -0.059032616699737916 DAHNALLDIQSSGR ddPTM_A459_Selumetinib_30min_R1 1 DAHNALLDIQSSGR 14 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 88.10799999999998 0.029799000000000006 4539200.0 707.38 994.09 907.6 1026.0 656.28 978.06 711.67 765.64 362.03 882.22 False True 723.8605776781251 877.7014806600972 784.3529050899401 846.8283604052958 596.9195898756451 968.2216044074268 657.9881589311963 745.3327400507798 614.3384683749719 995.4615305505127 0.7271607746386882 0.8817030630753842 0.7879288963142305 0.8506891872928335 0.5996410424273604 0.972635882646292 0.6609880329251036 0.748730832057964 0.6171393363992969 1.0 9.959221754081753 DAIHFYNK ddPTM_A459_Selumetinib_30min_R2 2 DAIHFYNK 8 0 P31948-2;P31948-3;P31948 P31948-2 STIP1 Stress-induced-phosphoprotein 1 0 ; 107.29 0.018775 18084900.0 344120.0 258370.0 325280.0 358370.0 366170.0 319600.0 325130.0 348300.0 293560.0 292390.0 False True 324995.188021506 278186.1482095095 304351.83893808525 309559.38777726836 320168.4509986659 363621.9989600605 340249.18923287245 349313.495335831 352280.2027517251 283947.94097954617 1.1445590586089744 0.9797082776858321 1.0718578831322072 1.090197684509947 1.1275603897466853 1.280593892336953 1.198280177905505 1.230202600275215 1.2406506683459315 1.0 18.115266924676895 -6.439247955612174 2.9773398692265065 1.2049149753871056 1.0641650430935656 0.30908094933947583 0.08054235078309974 0.2647923594128997 4.561952612998307 0.025457697008775957 0.028547487242269794 3.63707322179756e-07 6.439247955612174 -0.14074993229353994 DAINQGMDEELER ddPTM_A459_Selumetinib_30min_R1 1 DAINQGMDEELER 13 0 F8WF02;C9J634;P11177-3;P11177-2;P11177 F8WF02 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 201.09 0.014998 3257200.0 789.85 1078.8 613.7 712.02 789.18 601.43 957.09 924.01 274.27 539.21 False True 808.2519682194397 952.4935944794858 530.3629108127989 587.6790732707394 717.7988083410455 595.380160254748 884.8959307424205 899.5022531925205 465.41615811176877 608.4228558501761 1.3284378790964937 1.5655125137409975 0.8717011626259493 0.9659056487112889 1.1797696313331845 0.9785631071054967 1.4544094164672963 1.4784162766791629 0.7649550861487974 1.0 9.248930539750924 -5.2481829852713355 24.982179794685152 1.1120794617613194 1.4469752102528037 0.2825938168091726 0.22673970703228272 1096.080563756218 2065597.2186055623 0.05950202922868111 0.15541635840565338 5.6469899488165625e-06 5.2481829852713355 0.3348957484914843 DALDGPAAEAEPEHSFDGLR ddPTM_A459_Selumetinib_30min_R2 2 DALDGPAAEAEPEHSFDGLR 20 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 162.81 6.5211e-07 4947400.0 53859.0 51536.0 58048.0 55601.0 62680.0 51002.0 53044.0 56596.0 51397.0 52093.0 False True 50865.732394659644 55488.64548564183 54313.2548778837 48028.047882925144 54805.57803369032 58027.062549940536 55510.65110469196 56760.68499002785 61677.83615216786 50588.93973613145 1.0054714065954322 1.0968532998530296 1.0736191578866454 0.9493784240870881 1.0833509917296662 1.1470306128692525 1.0972882885909812 1.1219979166609897 1.2191960628919158 1.0 15.62653438241366 -6.519496024825148 23.64540490576324 1.1225670521152649 1.036198048492198 0.2916335222437906 0.06257701355266135 87.15079044547005 609199.5864314763 0.019921641614000157 0.020362274507232204 3.023458244637246e-07 6.519496024825148 -0.08636900362306688 DALDGPAAEAEPEHSFDGLRR ddPTM_A459_Selumetinib_30min_R2 2 DALDGPAAEAEPEHSFDGLRR 21 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 112.16 6.4984e-05 9928100.0 55819.0 68416.0 63459.0 65851.0 69386.0 41152.0 35062.0 38007.0 25499.0 67438.0 False True 52716.8034411613 73663.28720788703 59376.11702893503 56881.98020068885 60669.11036128964 46820.31445933793 36692.452474034944 38117.594077602436 30599.512501588193 65490.88971503331 0.8049486527140622 1.124786783755936 0.9066317053760434 0.8685479835164264 0.9263748076301239 0.7149133973147171 0.5602680408480122 0.5820289546143181 0.46723311646450477 1.0 15.999006610213714 -6.860170913172533 3.028816497520937 0.6180447671221765 0.9361603675798507 0.4199704354838729 0.15237855574374656 0.21555306121654352 3.969346312487824 0.054921363243429965 0.0483132079978657 1.379841132128226e-07 6.860170913172533 0.3181156004576742 DALFPAEGGAADCES(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 DALFPAEGGAADCESPR 17 0 Q8TF30 Q8TF30 WHAMM WASP homolog-associated protein with actin, membranes and microtubules 1 DALFPAEGGAADCES(1)PR 114.58 0.0021405 0.0 621.5 776.03 650.55 541.45 627.11 714.77 794.35 578.57 275.97 548.53 True False 635.9797407715156 685.1720468334405 562.2088832153601 446.8959217752901 570.3880112252631 707.5800627592345 734.431539965146 563.2244441397784 468.3009339486814 618.9391686346635 1.0275319013570308 1.1070103195195775 0.9083427123469234 0.7220352894471217 0.9215574649823813 1.1432142262382692 1.186597289658127 0.9099835212921039 0.7566186754373948 1.0 9.273653813395711 -5.2616242077643856 24.99656872477321 0.9474441191240531 1.067271109322129 0.11250019210637996 0.13866020883353114 40.94023449496238 5537985.91879634 0.04021647208390063 0.09328225165277977 5.474894971491803e-06 5.2616242077643856 0.11982699019807586 DALGDSLQVPVS(ph)PSSTTSSR ddPTM_A459_Selumetinib_30min_R1 4 DALGDSLQVPVSPSSTTSSR 20 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 DALGDSLQVPVS(0.687)PS(0.227)S(0.077)T(0.008)T(0.001)SSR;DALGDSLQVPVS(0.961)PS(0.026)S(0.008)T(0.001)T(0.003)S(0.001)SR;DALGDSLQVPVS(0.61)PS(0.236)S(0.094)T(0.028)T(0.028)S(0.003)SR;DALGDS(0.005)LQVPVS(0.974)PS(0.003)S(0.001)T(0.001)T(0.003)S(0.008)S(0.005)R 329.64 7.532299999999998e-155 500650000.0 12626.960000000001 13178.980000000001 14572.26 15663.85 14727.61 12506.11 12511.86 12553.12 8192.28 9447.47 True False 12921.143600212872 11635.97889485842 12593.427131694512 12928.452644380597 13395.500275870729 12380.309888039352 11568.080326843723 12220.170479319586 13901.700819542348 10660.144800650694 1.2120983196611144 1.091540416425503 1.1813561041802931 1.2127839617705236 1.256596465280009 1.161364139001532 1.085171031273197 1.146341884452983 1.3040817999670875 1.0 13.379939414434705 -6.993463131724843 24.938337914976167 1.1428329358122373 1.1883383415068067 0.0957214941289588 0.08060988649737674 501.3409018460258 1912619.3972821473 0.028537084431140357 0.0251044543098648 1.0151655426939931e-07 6.993463131724843 0.0455054056945694 DALGDSLQVPVS(ph)PSSTTSSR ddPTM_A459_Selumetinib_30min_R2 6 DALGDSLQVPVSPSSTTSSR 20 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 DALGDSLQVPVS(0.84)PS(0.134)S(0.022)T(0.001)T(0.001)S(0.001)SR;DALGDSLQVPVS(0.707)PS(0.212)S(0.024)T(0.006)T(0.024)S(0.024)S(0.003)R;DALGDSLQVPVS(0.959)PS(0.01)S(0.024)T(0.003)T(0.003)SSR;DALGDSLQVPVS(0.981)PS(0.015)S(0.004)TTSSR;DALGDSLQVPVS(0.852)PS(0.109)S(0.032)T(0.004)T(0.004)SSR;DALGDSLQVPVS(0.249)PS(0.13)S(0.13)T(0.13)T(0.133)S(0.133)S(0.094)R 278.32 8.311699999999998e-72 335187200.0 224599.1 222587.3 228880.3 249956.0 254062.0 185187.7 194956.7 204955.6 189700.1 251919.0 True False 212116.78116343403 239659.03017902505 214154.39068402874 215911.56160184904 222144.4602169021 210695.62470843544 204022.57284937208 205551.98686377396 227645.4206636543 244645.4439058314 0.867037528992699 0.9796177944408165 0.8753663557554775 0.8825488762625697 0.9080261486594848 0.8612284837380259 0.8339520638197708 0.8402036170471041 0.9305115886453185 1.0 17.900332889782185 -3.940420673891804 15.761468431331885 0.8921226393763808 0.8970814626232865 0.0 0.05390278514627071 0.0 0.0 0.01204788629865547 0.0 0.0001147042015379655 3.940420673891804 0.004958823246905664 DALGDSLQVPVSPS(ph)STTSSR ddPTM_A459_Selumetinib_30min_R1 1 DALGDSLQVPVSPSSTTSSR 20 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 DALGDSLQVPVS(0.178)PS(0.607)S(0.208)T(0.006)T(0.001)SSR 288.3 1.3293999999999995e-85 126520000.0 2864.5 3022.9 3076.4 3403.6 2689.8 2530.0 2964.4 2523.9 1644.0 1952.2 True False 2931.23727665327 2668.977462691916 2658.6417774555894 2809.2251534848597 2446.50806492276 2504.5504970562033 2740.792921347867 2456.9579732173934 2789.747926990732 2202.7838860383026 1.3306967130239398 1.2116383634402106 1.206946262094347 1.2753067476525075 1.110643708821928 1.1369932896869999 1.2442404989066682 1.1153876641236111 1.2664646516949432 1.0 11.10511224459652 -14.522878745280336 0.10438095083843835 0.40226160062435906 1.3251510931184112 0.48562451294271314 0.06704606612213979 160.29000664384682 1.122980085070161 21.13124323924137 0.978975835552726 3.0000000000000132e-15 14.522878745280336 0.922889492494052 DALGDSLQVPVSPS(ph)STTSSR ddPTM_A459_Selumetinib_30min_R2 1 DALGDSLQVPVSPSSTTSSR 20 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 DALGDSLQVPVS(0.159)PS(0.583)S(0.159)T(0.043)T(0.043)S(0.012)S(0.001)R 224.03 5.3479e-20 3873700.0 15858.0 15349.0 16773.0 18445.0 18748.0 16754.0 15307.0 15762.0 16527.0 20262.0 True False 14976.675844603746 16526.21894518622 15693.843441061601 15932.75918060024 16392.708630753463 19061.711422330583 16018.805830245077 15807.864810460434 19832.861802962787 19676.98341300165 0.7611266183569502 0.8398756353205264 0.7975736479348673 0.8097155364817049 0.8330905345949476 0.9687313864245816 0.8140884958850239 0.8033683049209321 1.007921864174472 1.0 14.264221444297766 -9.067950404662636 0.07190623089475097 1.3118148207398341 0.5397421217966948 0.5185443977166408 0.060419733629032094 39.78766482325188 1.2031284655019638 7.436715934295521 5.167059790356193 8.551643649280749e-10 9.067950404662636 -0.7720726989431393 DALNIET(ph)AIK ddPTM_A459_Selumetinib_30min_R1 2 DALNIETAIK 10 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 DALNIET(1)AIK;DALNIET(1)AIK 103.97 0.031916 5185300.0 4425.0 4808.5 4397.9 4412.200000000001 4269.8 4151.8 4355.1 5597.799999999999 2646.5 4399.799999999999 True False 4528.093890448846 4245.518584589 3800.689335935487 3641.6920972517046 3883.597343894416 4110.036661532785 4026.591300688875 5449.328159782998 4490.917207287697 4964.557187681246 0.9120841435132595 0.8551656117737095 0.7655646198146915 0.7335381504493452 0.7822646002610144 0.8278757814959172 0.8110675632219962 1.0976463667907046 0.9045957247569207 1.0 12.277449327365145 -7.741575851332543 24.966906255929235 1.0008407508838155 0.808734183925663 0.6497213738830725 0.06329516557057006 137.33489048193016 172619.60027062785 0.0304816684938825 0.017569028329769067 1.813109981037336e-08 7.741575851332543 -0.19210656695815254 DALNIETAIK ddPTM_A459_Selumetinib_30min_R1 2 DALNIETAIK 10 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ; 161.51 0.0058756 27647000.0 4090.6 3965.4 4157.4 4596.4 4572.5 3758.8 3802.3 3508.0 2778.8 3287.1 False True 4185.903021077976 3501.129124535554 3592.847914963549 3793.7250251139385 4158.918182340443 3720.9898847173363 3515.4894497507094 3414.9564444100824 4715.42064447801 3709.0313040654155 1.1285704212013168 0.9439470410233576 0.9686755436724086 1.0228344584085045 1.1212949801156742 1.0032241789490461 0.9478187595498135 0.9207138372401975 1.2713348197707326 1.0 11.856826728838774 -8.247184167078615 24.997488628973052 1.135667445630574 1.0059677572325114 0.24522997473424946 0.09017866764871166 948.5757073341563 1663398.5679917128 0.05981975725527127 0.022394481978068245 5.659992203013428e-09 8.247184167078615 -0.12969968839806256 DALNIETAIK ddPTM_A459_Selumetinib_30min_R2 3 DALNIETAIK 10 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;; 166.97 0.004294399999999999 13390800.0 115901.0 90635.0 103216.0 120593.0 109965.0 80419.0 92943.0 96498.0 76954.0 96454.0 False True 109459.68640846365 97586.41306254153 96575.1949330835 104168.02536547153 96150.21360042684 91495.9872790022 97265.03366306062 96778.7932038961 92346.9502744113 93669.12240241149 1.1685781141219023 1.04182051202851 1.0310248719763515 1.112084993365858 1.026487823675302 0.9767998774017195 1.0383895051904164 1.0331984620089123 0.9858846534045658 1.0 16.515285927983975 -1.5228787452803376 0.5859490098981187 1.016332327715805 8.520052349408873 0.5863583513149528 0.0355460250609773 127.13033881772536 1.0342433576576084 0.017184450867390833 1216.0176181324287 0.029999999999999995 1.5228787452803376 7.503720021693068 DALQDS(ph)LAR ddPTM_A459_Selumetinib_30min_R1 1 DALQDSLAR 9 0 Q96A99-2;Q96A99 Q96A99-2 PTX4 Pentraxin-4 1 DALQDS(1)LAR 91.069 0.027708 6324000.0 2817.9 2699.1 2702.3 3501.6 3179.9 2885.4 2483.7 2428.3 1352.2 2167.2 True False 2883.5515873210875 2383.088117222453 2335.342502671382 2890.1112931726966 2892.278606456945 2856.3754957335846 2296.3525093616577 2363.8935957699564 2294.584639219504 2445.381230315649 1.179182841339172 0.9745262160676864 0.9550014017118863 1.1818653293579267 1.182751617866802 1.1680696082569033 0.9390570602626426 0.9666769199274609 0.9383341177127297 1.0 11.255843680805521 -7.2737113305793955 24.82176122839262 0.9582400900293557 1.100833437168106 0.4436477781236293 0.07983476535042501 773.3494488656604 1564202.46212418 0.036852420839447564 0.02506866377569172 5.324620616972148e-08 7.2737113305793955 0.14259334713875038 DAMEQCHNYNAR ddPTM_A459_Selumetinib_30min_R1 1 DAMEQCHNYNAR 12 0 J3KMZ8;Q92785-2;Q92785;E9PN04 J3KMZ8 DPF2 Zinc finger protein ubi-d4 0 141.89 0.019103 7928000.0 3063.4 3386.8 3946.0 4128.1 3913.8 3465.4 3522.9 3010.3 1711.8 2732.5 False True 3134.771259661241 2990.271881519397 3410.15487382647 3407.204829034213 3559.7974810375113 3430.5412223314506 3257.1648166969367 2930.4570651675244 2904.799575074657 3083.242991803946 1.0167123603278334 0.9698463239739163 1.1060285818832767 1.1050717825651242 1.154562741405841 1.1126405643183856 1.0564087311169827 0.9504463556578038 0.9421247636973026 1.0 11.590232878050136 -7.693945439562977 4.680653182360017 0.9593800413037313 1.0788784350547893 0.4951049012377571 0.051194206623279746 0.18662280411219745 7.82764482414975 0.02935236585842118 0.0159466329818 2.0232733466419593e-08 7.693945439562977 0.11949839375105797 DAMQYASESK ddPTM_A459_Selumetinib_30min_R1 1 DAMQYASESK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 166.66 0.047245 5054800.0 1467.4 2082.7 1544.9 1629.5 1591.5 1575.5 1639.3 1579.6 912.69 1937.1 False True 1501.587564936641 1838.8565157790385 1335.11106552826 1344.9384145033434 1447.549106002147 1559.651900439545 1515.6462811919992 1537.7038767360798 1548.7682697598361 2185.745653951847 0.686990987364773 0.8412948288170539 0.6108263617563954 0.6153224699642811 0.6622678642343247 0.7135559883738901 0.6934229874604566 0.7035145530111877 0.7085766209621187 1.0 11.093909815072012 -9.860883187060846 0.8141425555724647 1.0137908280433532 0.6886713850559012 0.7027184429127009 0.06008321478428873 7.82329343251928 3.98416585085777 0.4174464682346886 0.021124083536203646 1.3775799491327457e-10 9.860883187060846 -0.325119442987452 DANVS(ph)GTLVSSSTLEK ddPTM_A459_Selumetinib_30min_R1 1 DANVSGTLVSSSTLEK 16 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 DANVS(0.833)GT(0.167)LVSSSTLEK 252.77 1.2277e-29 6234100.0 1677.4 2061.7 2258.2 2226.1 1912.6 1988.6 1895.0 1657.3 966.83 1298.8 True False 1716.4801563477736 1820.3152055416722 1951.5488434046974 1837.3534240723488 1739.6056676969547 1968.5964895043358 1752.0586243267473 1613.343020330911 1640.6398955306863 1465.5136313833352 1.1712481682804579 1.2421004940250409 1.3316483733846824 1.253726601190345 1.1870279678360256 1.343280913495242 1.1955253003501134 1.1008720668179905 1.1194982157771163 1.0 10.517190671889594 -7.995022148129341 1.2227222378331302 1.0257050716897769 1.2564750036294057 0.673582546654357 0.05700090251501951 0.27333228742113785 0.739586019306091 0.0523275026689373 0.018163650520370923 1.0115278670944127e-08 7.995022148129341 0.2307699319396288 DANVSGT(ph)LVSSSTLEK ddPTM_A459_Selumetinib_30min_R1 1 DANVSGTLVSSSTLEK 16 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 DANVS(0.158)GT(0.842)LVSSSTLEK 194.67 2.8564e-06 5722400.0 1326.6 1313.0 1445.5 1686.4 1161.4 1448.5 1362.3 1251.8 728.35 937.29 True False 1357.5071988857483 1159.2733496028598 1249.2090395631435 1391.9018976486273 1056.3515750618242 1433.9294051327713 1259.5406142059771 1218.5981975805423 1235.956753420742 1057.600301477738 1.2835730067294455 1.0961356081149547 1.1811731122028608 1.316094459980566 0.998819283226216 1.3558330147308064 1.190941996183319 1.15222943476647 1.1686425880304634 1.0 10.046578777872575 -9.03940201053109 1.051178560048698 0.9998673969132741 1.1979301313838437 0.2639071084572372 0.09899199735261287 2.6833196053442157 4.167931278801743 0.09162630109975355 0.02850536479604901 9.132674717573209e-10 9.03940201053109 0.19806273447056966 DANVSGTLVSSS(ph)TLEK ddPTM_A459_Selumetinib_30min_R1 1 DANVSGTLVSSSTLEK 16 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 DANVSGTLVSSS(0.743)T(0.256)LEK 242.67 1.1089000000000002e-21 5866200.0 1847.7 2008.1 2270.9 2533.9 1946.8 1793.0 1997.3 2136.7 1358.3 1693.5 True False 1890.7478150016584 1772.9907184596373 1962.5242531608044 2091.4019321939386 1770.7122837354557 1774.9640479137452 1846.6420529645445 2080.0277750202476 2304.935893693133 1910.8772210869104 0.9894658820236486 0.9278412547359568 1.0270279175992882 1.0944721665604165 0.92664890459486 0.928873937229804 0.9663844608049549 1.0885198442195696 1.2062187294179378 1.0 10.900019368985026 -7.83380461862203 5.052125721938665 1.1156570510181893 0.9802876570690432 0.3882247743659173 0.06750549805205615 0.19966815959132475 9.287698413212208 0.0386421761875611 0.01821024302811882 1.4662073132449994e-08 7.83380461862203 -0.13536939394914616 DANVSGTLVSSS(ph)TLEK ddPTM_A459_Selumetinib_30min_R2 1 DANVSGTLVSSSTLEK 16 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 DANVSGTLVS(0.001)S(0.01)S(0.696)T(0.292)LEK 214.24 1.4204e-08 2840600.0 19257.0 21620.0 19603.0 21097.0 23450.0 14833.0 14897.0 15062.0 15260.0 19288.0 True False 18186.773031878824 23278.18448074312 18341.76432213262 18223.55220564506 20504.001354340115 16876.111109432335 15589.740017845495 15105.827926351662 18312.42640002493 18731.105323757572 0.9709396598614848 1.2427555170072246 0.9792142003957913 0.9729031944810669 1.0946498351239258 0.9009671782704431 0.8322915144827182 0.8064568355820521 0.9776479328637584 1.0 14.19314841517166 -6.803006827398979 7.825878223447135 0.8862358916976416 1.0541731519966082 0.3815299613300305 0.09333543110293091 0.22450778809173316 35.97192108437539 0.03265520885636832 0.029024177985098275 1.5739581206000595e-07 6.803006827398979 0.1679372602989666 DANVSGTLVSSST(ph)LEK ddPTM_A459_Selumetinib_30min_R1 1 DANVSGTLVSSSTLEK 16 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 DANVSGTLVSSS(0.486)T(0.514)LEK 273.77 1.8849999999999998e-50 5807300.0 2207.5 2498.3 3007.7 3164.6 2584.6 2176.3 2245.7 2540.8 1446.1 1904.5 True False 2258.9304549527305 2205.797874571841 2599.2708601135005 2611.962016899221 2350.823386348193 2154.4083979222983 2076.3050409765565 2473.409730318456 2453.926081034852 2148.961126400956 1.051173251670657 1.0264484766488422 1.2095476405693368 1.215453357815593 1.0939348122528918 1.0025348394879834 0.9661901350695521 1.1509792801421592 1.1419127367578985 1.0 11.069423670054208 -6.52482830255974 24.90668100038346 1.0554716616967492 1.1283282796873437 0.16383820556750417 0.07807952642613643 128.13563766455002 1636972.2088840266 0.0283071268753554 0.02849194756154687 2.9865631172038385e-07 6.52482830255974 0.07285661799059451 DANVSGTLVSSST(ph)LEK ddPTM_A459_Selumetinib_30min_R2 1 DANVSGTLVSSSTLEK 16 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 DANVSGTLVS(0.005)S(0.053)S(0.336)T(0.606)LEK 130.09 0.0019071 2953800.0 15020.0 13254.0 11608.0 12142.0 13973.0 10170.0 12045.0 12335.0 9342.1 12353.0 True False 14185.248529823946 14270.539181672952 10861.15391783479 10488.238653881706 12217.586819795073 11570.825185931828 12605.116366714712 12370.892807830827 11210.781040083424 11996.336793051489 1.1824650119893532 1.1895747366761764 0.905372540401315 0.8742867789404427 1.0184431323128353 0.9645298715382745 1.0507471225729375 1.0312225324480961 0.9345170307803401 1.0 13.55030631060703 -5.2502784798832405 24.767993809018854 0.9741638027562667 1.1860199192025793 0.7217124602653819 0.05305326441545112 356.3030992111119 790694.899076637 0.01469381328383986 0.03807165977674871 5.619808542293214e-06 5.2502784798832405 0.21185611644631264 DAPERDDPPASAAWS(ph)PVQADVSSAGPK ddPTM_A459_Selumetinib_30min_R1 1 DAPERDDPPASAAWSPVQADVSSAGPK 27 1 U3KQ39;Q96JE7-2;Q96JE7 U3KQ39 SEC16B Protein transport protein Sec16B 1 DAPERDDPPASAAWS(0.982)PVQADVS(0.013)S(0.005)AGPK 86.99700000000001 2.8339e-05 4736700.0 2358.3 2899.7 2988.4 2649.5 2591.5 2225.6 2566.0 2558.7 1565.1 2735.1 True False 2413.2438015470098 2560.2017759660416 2582.591694106189 2186.814562274691 2357.0992825664853 2203.2124846831184 2372.4445541015466 2490.8349641710615 2655.860389618731 3086.176727130089 0.7819525629665233 0.8295706961496128 0.8368256008811926 0.708583712348924 0.7637603063510914 0.713897057584236 0.7687325658462018 0.8070940793100172 0.860566527597556 1.0 11.591604963568113 -8.610303360586753 1.494934720171409 0.9991466143034032 0.7721895340534919 0.7581723783102199 0.03928930977223134 0.26838403875392386 1.2878001738007656 0.04133243951285108 0.012130454958335998 2.45299486692249e-09 8.610303360586753 -0.22695708024991135 DAPERDDPPASAAWS(ph)PVQADVSSAGPK ddPTM_A459_Selumetinib_30min_R2 2 DAPERDDPPASAAWSPVQADVSSAGPK 27 1 U3KQ39;Q96JE7-2;Q96JE7 U3KQ39 SEC16B Protein transport protein Sec16B 1 DAPERDDPPASAAWS(0.998)PVQADVS(0.001)S(0.001)AGPK;DAPERDDPPAS(0.103)AAWS(0.89)PVQADVS(0.005)S(0.002)AGPK 84.646 3.6847e-05 8315800.0 71879.0 65519.0 77339.0 78784.0 75785.0 56259.0 59881.0 59962.0 50977.0 69435.0 True False 67884.25293443518 70544.09662321045 72363.09294033636 68053.48329001931 66264.2107735038 64008.16658164589 62665.58515195048 60136.4794927565 61173.82441638737 67430.23113620421 1.0067332083930407 1.0461790718278343 1.0731550481292007 1.0092429188409007 0.9827077507661937 0.9492502917920302 0.9293396166086174 0.8918326169056895 0.9072165909207793 1.0 16.041107922469543 -6.517393461045678 1.4564133830987114 0.9239671652707058 1.0416506338178062 0.6866679183451945 0.03147414809261366 0.21129972233324906 0.9187420207676668 0.012840975154299087 0.014290019424790688 3.0381312997412753e-07 6.517393461045678 0.11768346854710043 DAPIS(ph)PASIASSSSTPSSK ddPTM_A459_Selumetinib_30min_R1 4 DAPISPASIASSSSTPSSK 19 0 Q04727-4;Q04727;Q04727-3;H0Y5S0;H7C4E4 Q04727-4 TLE4 Transducin-like enhancer protein 4 1 DAPIS(0.991)PAS(0.009)IASSSSTPSSK;DAPIS(0.999)PAS(0.001)IASSSSTPSSK;DAPIS(1)PASIASSSSTPSSK;DAPIS(1)PASIASSSSTPSSK 286.16 1.2279999999999995e-72 71589200.0 13365.899999999998 14214.2 16155.1 16067.9 14779.5 13359.1 14392.8 13008.1 7425.1 11362.900000000001 True False 13677.299464485923 12549.994855997706 13961.326153612272 13261.94289683846 13442.696834532664 13224.719583092312 13307.139508290244 12663.08293173626 12599.85239215261 12821.438899018873 1.0667523023123826 0.9788288939206395 1.0889047838991477 1.0343568300944206 1.0484546188931518 1.0314536213329613 1.0378819111565192 0.9876491267064628 0.982717500850609 1.0 13.646270558509999 -7.752864886580517 7.441068466294312 0.9887297492211673 1.0401566545501342 0.42959366915976205 0.026816364215784448 0.12005862595118098 39.09875727083366 0.012763894074179346 0.006853265968868668 1.7665873384454732e-08 7.752864886580517 0.051426905328966876 DAPIS(ph)PASIASSSSTPSSK ddPTM_A459_Selumetinib_30min_R2 3 DAPISPASIASSSSTPSSK 19 0 Q04727-4;Q04727;Q04727-3;H0Y5S0;H7C4E4 Q04727-4 TLE4 Transducin-like enhancer protein 4 1 DAPIS(0.96)PAS(0.036)IAS(0.003)SSSTPSSK;DAPIS(0.877)PAS(0.069)IAS(0.019)S(0.027)S(0.006)S(0.001)TPSSK;DAPIS(0.89)PAS(0.11)IASSSSTPSSK 189.84 2.7823e-15 44295400.0 46032.0 47936.0 52750.0 62378.0 62076.0 47185.0 44990.0 41879.0 41295.0 60125.0 True False 43473.725720696144 51612.537061466275 49356.12242985746 53882.008791948036 54277.45791351883 53684.30544721665 47082.124145993774 42000.86095655833 49555.15387870445 58389.0350264892 0.7445529062258613 0.8839422853631911 0.8452977927699302 0.9228104004031499 0.9295830610815015 0.9194244334207927 0.8063521536986209 0.7193278830092656 0.8487065055317817 1.0 15.833409848001262 -10.248443478988479 14.97236190580167 0.9999963093358049 0.8496097161493207 0.3064709157017228 0.06907084094208257 0.0 0.0 0.07263036657189564 0.017615451353132697 5.643603849313103e-11 10.248443478988479 -0.15038659318648417 DAPQDFHPDR ddPTM_A459_Selumetinib_30min_R1 3 DAPQDFHPDR 10 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ;; 158.56 0.00066504 119748000.0 23231.6 25227.300000000003 26414.1 27384.1 26670.0 22428.6 23154.4 22038.300000000003 12525.7 19424.0 False True 23772.851079175463 22273.67598814642 22827.210302265517 22601.980998220926 24257.703208970943 22202.988647539438 21407.844966285604 21453.772693512758 21255.19805906801 21917.259605782183 1.0846634801416388 1.016261904488744 1.0415175397312568 1.0312411955123304 1.1067854122862744 1.0130367138454606 0.976757375298772 0.97885288030502 0.9697926858274057 1.0 14.41977980374655 -6.995942290568557 24.969928942725296 0.981775407942112 1.0525125746158284 0.6610768381454092 0.025251016385605795 73.49327677300106 452251.36425484857 0.008927131815150117 0.007839997425909318 1.0093870053956116e-07 6.995942290568557 0.07073716667371632 DAPQDFHPDR ddPTM_A459_Selumetinib_30min_R2 4 DAPQDFHPDR 10 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ;;; 129.74 0.0040702 296349000.0 304369.0 306736.0 340168.0 336758.0 376254.0 262973.0 284008.0 266743.0 249523.0 320354.0 False True 287453.3894656452 330261.66488830716 318281.96122691466 290890.9794600471 328985.60876656265 299195.143718786 297214.9347511758 267519.1779683192 299434.57225513924 311104.5476403477 0.9239768163014949 1.0615777473947634 1.0230707446773308 0.9350264458246734 1.0574760518990753 0.9617189654992458 0.9553538738198423 0.8599012132654026 0.9624885734595576 1.0 18.247039958380867 -7.1111322227544616 3.0883709487820687 0.9323458268252031 1.0016052116235974 0.17448522144927525 0.054053026485539314 0.3672551482494989 6.6688434479124545 0.021551798475964452 0.01631890966783033 7.742260455889801e-08 7.1111322227544616 0.06925938479839433 DAPSLEEVEGHVADGS(ph)ATEMGTTK ddPTM_A459_Selumetinib_30min_R1 2 DAPSLEEVEGHVADGSATEMGTTK 24 0 C9J470;E9PHA2;Q15003;Q15003-2 C9J470 NCAPH Condensin complex subunit 2 1 DAPSLEEVEGHVADGS(0.937)AT(0.062)EMGT(0.001)TK;DAPSLEEVEGHVADGS(0.989)AT(0.011)EMGTTK 184.93 2.0423e-21 38811000.0 4355.7 5772.7 5243.8 5544.4 4821.3 4859.7 5206.7 5203.6 2828.5 4344.9 True False 4457.179335283171 5096.829600344579 4531.720762131586 4576.174621277896 4385.214266269652 4810.815830254557 4813.954427061782 5065.583624325063 4799.757914533629 4902.610237909957 0.9091441332246966 1.0396155013369819 0.924348569888255 0.933415955829435 0.8944652039357556 0.9812764214977586 0.9819166104287397 1.0332421666227711 0.9790209055206938 1.0 12.259334355242276 -6.9861644103578975 24.401971942991146 0.9984981705421665 0.9438044746672489 0.3369447495577107 0.0389430636123947 223.77771872065168 394676.8979223431 0.013977693131956273 0.01232062427015721 1.0323705084702536e-07 6.9861644103578975 -0.05469369587491757 DAPSLEEVEGHVADGS(ph)ATEMGTTK ddPTM_A459_Selumetinib_30min_R2 4 DAPSLEEVEGHVADGSATEMGTTK 24 0 C9J470;E9PHA2;Q15003;Q15003-2 C9J470 NCAPH Condensin complex subunit 2 1 DAPSLEEVEGHVADGS(0.993)AT(0.007)EMGTTK;DAPSLEEVEGHVADGS(0.904)AT(0.093)EMGT(0.002)T(0.001)K;DAPSLEEVEGHVADGS(0.999)AT(0.001)EMGTTK;DAPSLEEVEGHVADGS(0.987)AT(0.012)EMGTTK 133.46 8.9268e-08 17400700.0 98135.0 99341.0 106624.0 122585.0 110768.0 96585.0 104031.0 106528.0 83077.0 113282.0 True False 92681.04956553092 106960.13526833958 99763.92792343361 105888.71152908014 96852.33356151576 109888.70703866518 108868.64763351568 106837.97884334034 99694.72136532598 110011.25431801652 0.8424688013974636 0.9722653916765926 0.9068520174766819 0.9625261723039801 0.8803856856457483 0.9988860477947366 0.9896137291444943 0.9711549923292122 0.906222931311483 1.0 16.74729159562539 -6.769152418248553 24.99980641585097 0.9724001125343267 0.9186187645476449 0.32706588888875476 0.04283153871502993 234.5216730415529 760135.8457441129 0.014455027702306729 0.012981036972844716 1.701561230490833e-07 6.769152418248553 -0.05378134798668177 DAPTS(ph)PASVASSSST(ph)PSSK ddPTM_A459_Selumetinib_30min_R1 1 DAPTSPASVASSSSTPSSK 19 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 2 DAPT(0.181)S(0.712)PAS(0.016)VAS(0.085)S(0.004)S(0.002)S(0.061)T(0.937)PS(0.001)S(0.001)K 157.57 0.00047602 3948700.0 1504.5 1903.5 1857.0 1664.0 1722.2 1549.9 1682.2 1137.1 816.17 1542.8 True False 1539.5519227526086 1680.6373350868578 1604.829599770846 1373.413637148551 1566.427314079106 1534.3094131966059 1555.3102996530097 1106.9404141786508 1384.9808793017178 1740.8334081446037 0.8843763656819277 0.9654211179679143 0.9218743116156578 0.7889403033759261 0.8998145984276684 0.88136487157142 0.8934285683951078 0.6358680899618293 0.7955849611008116 1.0 10.765562433232269 -7.624957174279645 22.104680097954585 0.7823515570229591 0.8909309126144878 0.11461221279141653 0.09280879225523046 7.7325330931372855 1656.8620139386887 0.04188968529465761 0.024184977315560335 2.3716075580331987e-08 7.624957174279645 0.10857935559152865 DAPTS(ph)PASVASSSSTPSSK ddPTM_A459_Selumetinib_30min_R1 2 DAPTSPASVASSSSTPSSK 19 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 DAPT(0.028)S(0.972)PASVASSSSTPSSK;DAPT(0.022)S(0.972)PAS(0.006)VASSSSTPSSK 276.8 1.9022999999999997e-71 71143000.0 8709.1 10497.7 10805.3 10905.9 10261.5 8653.3 9906.0 9836.9 5376.6 8170.099999999999 True False 8912.005085041363 9268.624403751668 9337.999609264363 9001.389294097584 9333.349136814972 8566.255658567761 9158.782444633645 9575.993457245597 9123.697508672969 9218.811918513231 0.9667194822734437 1.0054033519371843 1.012928747413946 0.9764153313531629 1.0124242927737497 0.9292147116446746 0.9934883719930293 1.038744855832786 0.9896825739931571 1.0 13.170365118861879 -7.536154494073149 24.93483691569236 1.0117515595563464 0.9849663555713231 0.1591707403153514 0.026118185262294032 409.8266492997912 769735.6683186577 0.012223389519762517 0.007062002498470742 2.9096818560809517e-08 7.536154494073149 -0.026785203985023376 DAPTS(ph)PASVASSSSTPSSK ddPTM_A459_Selumetinib_30min_R2 4 DAPTSPASVASSSSTPSSK 19 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 DAPT(0.4)S(0.462)PAS(0.131)VAS(0.005)S(0.001)SSTPSSK;DAPT(0.009)S(0.954)PAS(0.027)VAS(0.009)S(0.002)SSTPSSK;DAPT(0.004)S(0.995)PASVASSSSTPSSK;DAPT(0.047)S(0.942)PAS(0.008)VAS(0.002)SSSTPSSK 212.41 9.476e-17 189052000.0 130937.0 125846.0 126531.0 155179.0 142018.0 101780.0 108242.0 113579.0 92379.0 117997.0 True False 123660.04572234082 135497.9835413319 118390.13321653652 134043.3525012941 124176.42918297123 115799.27113315054 113275.4674774541 113909.49608598436 110857.38128492172 114590.12001697534 1.0791510271917149 1.1824578202838016 1.0331617874123724 1.1697636103482305 1.0836573795766666 1.0105519665743965 0.9885273482624288 0.9940603611298238 0.9674253004403813 1.0 16.806123134439318 -6.741022598048808 2.920460212329225 0.9883360611634473 1.1162155369185731 0.68601562429803 0.04037959733786947 0.14145218026179382 2.478137970729022 0.013852164057937474 0.013028684625289168 1.8154211968153905e-07 6.741022598048808 0.12787947575512582 DAPVHGS(ph)PTGPGAWTASK ddPTM_A459_Selumetinib_30min_R1 1 DAPVHGSPTGPGAWTASK 18 0 Q9BRP1 Q9BRP1 PDCD2L Programmed cell death protein 2-like 1 DAPVHGS(0.656)PT(0.344)GPGAWTASK 91.565 0.0035198 9997900.0 3959.9 4269.3 4772.5 5149.6 3985.3 3623.4 3661.7 3718.7 2379.7 3256.2 True False 4052.157965375909 3769.448371256275 4124.420713465996 4250.319029964047 3624.830318661863 3586.9518857839716 3385.495020948417 3620.067995960026 4038.177093588711 3674.1649880739274 1.102878607392134 1.0259333436281797 1.1225464090081874 1.15681223999474 0.9865725492534492 0.9762631502469151 0.921432497434788 0.9852763846235821 1.0990734239470303 1.0 11.84320069666706 -6.281993619016621 24.028458810890097 0.9894412855939906 1.0980708223807127 0.5107510303873491 0.05121686153133291 423.32010770182785 494871.17883608816 0.016767412821160035 0.01903753495852468 5.224038644958777e-07 6.281993619016621 0.10862953678672216 DAPVHGS(ph)PTGPGAWTASK ddPTM_A459_Selumetinib_30min_R2 4 DAPVHGSPTGPGAWTASK 18 0 Q9BRP1 Q9BRP1 PDCD2L Programmed cell death protein 2-like 1 DAPVHGS(0.946)PT(0.054)GPGAWTASK;DAPVHGS(0.931)PT(0.069)GPGAWTASK;DAPVHGS(0.977)PT(0.023)GPGAWTASK;DAPVHGS(0.992)PT(0.008)GPGAWTASK 112.36 0.00082112 39349700.0 219204.0 213370.0 229103.0 242039.0 261624.0 199660.0 215977.0 209087.0 177336.0 232663.0 True False 207021.5192231378 229734.7929073152 214362.76240848599 209072.8706594365 228756.45417176464 227161.3526669766 226020.35845030675 209695.40855378378 212808.1551818358 225945.41465892768 0.9162457203906698 1.016771211109142 0.948736944859332 0.9253246894832504 1.0124412328397119 1.005381556469665 1.0003316898087629 0.9280799474082099 0.9418564899981573 1.0 17.785614753658827 -4.726424333568749 24.188025356504845 0.9736583491903054 0.9162450349132094 0.2090768241425377 0.03438097101723362 6930.680120070914 4787208.015339803 0.008983905396512169 1.8012641917086314 1.877481500472246e-05 4.726424333568749 -0.05741331427709595 DAQHYGGWEHR ddPTM_A459_Selumetinib_30min_R1 2 DAQHYGGWEHR 11 0 F5H6X6;Q14697;Q14697-2;E9PKU7 F5H6X6 GANAB Neutral alpha-glucosidase AB 0 ; 142.97 0.00049518 79086000.0 22093.0 30070.0 27464.0 30357.0 26537.0 24606.0 24766.0 21205.0 12363.2 19937.5 False True 22607.723914505394 26549.390420836262 23734.539648953403 25055.71982146546 24136.73303548787 24358.485980460468 22897.88068077902 20642.574516452627 20979.447427598436 22496.672332695758 1.0049363559271047 1.1801474470626683 1.0550244630828614 1.1137522674876001 1.0729023687831605 1.0827595130617973 1.0178341197377963 0.9175834635085803 0.932557807543285 1.0 14.457423995917825 -7.482486065376726 2.7944603887040187 0.944160891803131 1.0889643750388978 0.6249818366558151 0.046644924869996815 0.15814742130771878 2.4580344998279866 0.022346543575920003 0.01284780956003259 3.292410170778914e-08 7.482486065376726 0.14480348323576675 DAQHYGGWEHR ddPTM_A459_Selumetinib_30min_R2 4 DAQHYGGWEHR 11 0 F5H6X6;Q14697;Q14697-2;E9PKU7 F5H6X6 GANAB Neutral alpha-glucosidase AB 0 ;;; 124.39 0.0020238 78933200.0 227752.0 176971.0 226649.0 216303.0 248839.0 193008.0 180682.0 197585.0 188238.0 191022.0 False True 215094.45560349288 190544.1066485471 212066.65009677256 186842.15825651283 217577.62017111474 219593.10004782016 189084.07101459106 198159.9396380424 225890.8598091668 185506.6985252391 1.1594969740363754 1.0271548583601289 1.143175161774117 1.0071989838743858 1.172882822565635 1.1837475508623934 1.0192843305271009 1.0682090793130132 1.2176965123360937 1.0 17.501111756995357 -4.4868655093736045 15.334654463460167 1.097034264532632 1.3821828654802304 0.060615352758947694 0.07694521444435219 4794698.50295705 65295702.431372195 0.018447013832928627 36497772.21259189 3.259376204699221e-05 4.4868655093736045 0.2851486009475983 DAQNSSDSS(ph)FEK ddPTM_A459_Selumetinib_30min_R2 1 DAQNSSDSSFEK 12 0 Q6PL18 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 DAQNS(0.001)S(0.008)DS(0.037)S(0.955)FEK 134.4 0.0029162 0.0 25306.0 25258.0 28484.0 31143.0 25693.0 23287.0 30490.0 29865.0 22997.0 24804.0 True False 23899.593827944398 27195.20738272938 26651.370451034298 26901.26967532844 22465.215641665698 26494.57287166122 31907.845414788844 29951.90220558311 27597.042589867193 24087.844071468407 0.9921848446475545 1.1290013046431824 1.1064240690017726 1.1167985642680442 0.9326370419457887 1.0999146620615805 1.3246451330438112 1.2434447066626675 1.1456833790515675 1.0 14.556017653715736 -7.016729805097398 24.5584054006894 1.200666028071701 1.0607956567885097 0.2567849919419575 0.09565204779553166 696.9033471831613 1023012.6667135425 0.03527011429269452 0.028060364704310503 9.622107284847562e-08 7.016729805097398 -0.13987037128319124 DAQRLS(ph)PIPEEVPK ddPTM_A459_Selumetinib_30min_R1 3 DAQRLSPIPEEVPK 14 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 DAQRLS(1)PIPEEVPK;DAQRLS(1)PIPEEVPK;DAQRLS(1)PIPEEVPK 147.75 0.0022431 67044000.0 13570.2 17672.0 12307.5 11368.3 11247.3 12635.900000000001 16624.6 14600.5 7094.700000000001 14150.699999999999 True False 13886.359256987329 15602.954024510094 10636.209100258307 9383.039814420597 10229.9837008721 12508.794318479248 15370.593037457753 14213.247310892088 12039.18772361384 15967.080184490436 0.8696868241743905 0.9771951943766128 0.6661336310310353 0.5876490695859834 0.6406921981145279 0.783411505043334 0.9626426910781046 0.890159449734465 0.7540005802255606 1.0 13.962812898404891 -7.078382218549777 6.429041701061371 0.8912615110416111 0.7441248287744961 0.2637417693392753 0.12131327328835205 0.3999617019174947 26.914166436772245 0.051885466765595564 0.04028188907352055 8.348679352740767e-08 7.078382218549777 -0.14713668226711496 DAQRLS(ph)PIPEEVPK ddPTM_A459_Selumetinib_30min_R2 1 DAQRLSPIPEEVPK 14 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 DAQRLS(1)PIPEEVPK 105.01 0.0032879 6838000.0 73942.0 51763.0 65087.0 69143.0 63686.0 59524.0 62507.0 70539.0 51614.0 61923.0 True False 69832.59965327843 55733.05565572181 60899.37328136745 59725.60412167213 55685.19531993625 67722.89069492694 65413.69935527078 70744.25681163985 61938.24221565443 60135.12209472419 1.161261459539051 0.9267970815446538 1.012708898893386 0.9931900367241794 0.9260012016309127 1.1261786512755487 1.0877786071878566 1.1764216043363853 1.029984475928892 1.0 15.875920226923242 -6.7781221851169455 24.999768447824188 1.0953306484596803 0.999587322069558 0.20872805749762824 0.07616260050679112 319.60186455274953 478931.58340974886 0.025527086975186603 0.022573660899991285 1.666778212482279e-07 6.7781221851169455 -0.09574332639012229 DAS(ph)EETSTSVMQK ddPTM_A459_Selumetinib_30min_R2 2 DASEETSTSVMQK 13 0 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 DAS(1)EETSTSVMQK;DAS(0.637)EET(0.313)S(0.005)T(0.032)S(0.013)VMQK 204.13 4.4218e-05 22317000.0 64112.0 55201.0 72206.0 70609.0 78408.0 55120.0 57509.0 57729.0 42999.0 60933.0 True False 60548.911700670666 59434.73920080944 67560.34457194872 60991.93239268099 68557.68606358643 62712.27967045845 60183.28245192162 57896.98183244959 51600.001492442505 59173.7059670531 1.023240148832038 1.0044113044719842 1.1417291424938834 1.0307269317666237 1.158583613163559 1.059799764871505 1.0170612346881 0.9784241308916096 0.8720089548079428 1.0 15.852668631454366 -7.662954622552296 2.0904094722494517 0.936063619797751 1.07162505740143 0.49237262487560596 0.05485408699469675 0.2661482869641267 2.3105192941044606 0.03539274215327259 0.01615442649566527 2.1729282063510904e-08 7.662954622552296 0.1355614376036791 DAS(ph)PINR ddPTM_A459_Selumetinib_30min_R2 1 DASPINR 7 0 Q13523;H0YDJ3 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 DAS(1)PINR 91.265 0.028563 25916000.0 128640.0 89506.0 99727.0 119400.0 119790.0 113510.0 216330.0 297740.0 221460.0 133780.0 True False 121490.70378672113 96370.82239284902 93310.67339454778 103137.51402351166 104740.9092638125 129144.97215881258 226389.77364976262 298606.37410648935 265758.18810940447 129917.42379781668 0.9351378763158852 0.7417852015202027 0.7182306319417326 0.7938697597946437 0.806211408770043 0.9940542875895829 1.7425666783701048 2.2984320761408723 2.0455931186180947 1.0 16.98723540438347 -7.239106365187802 3.141544395502082 1.9042211541844702 0.7989143575085568 0.6718701730765048 0.3204768117397125 0.13274992983514314 2.6845108668939988 0.13331676661584974 0.09323431669908039 5.766252219907086e-08 7.239106365187802 -1.1053067966759134 DAS(ph)PSKEER ddPTM_A459_Selumetinib_30min_R1 1 DASPSKEER 9 1 Q9BUQ8;F8W1J5;F8VVA2;Q9BUQ8-2 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 1 DAS(0.997)PS(0.003)KEER 128.88 0.020021 8344900.0 2885.6 6885.1 5450.4 4151.0 3012.3 3325.9 2571.4 4126.8 4834.7 3559.2 True False 2952.8288655998185 6078.989291203851 4710.265616904153 3426.1057739204516 2739.837996864759 3292.4444656755863 2377.4372277539837 4017.3438582644076 8204.13278748302 4016.057989543864 0.7352555349767733 1.5136706957496624 1.1728579689754768 0.8531016690597094 0.6822207258954307 0.8198199513671703 0.5919827935612076 1.0003201818110923 2.042832252134594 1.0 11.971564385779294 -9.972589026439975 9.02262214080444 1.0000022854848134 1.0255929207945031 0.0 0.4192416043919833 0.0 0.0 0.4150085303880057 0.10065435331306498 1.0651504950708562e-10 9.972589026439975 0.025590635309689747 DAS(ph)PTPSTDAEYPANGSGADR ddPTM_A459_Selumetinib_30min_R1 2 DASPTPSTDAEYPANGSGADR 21 0 E9PEE2;E7EPF5;O43639 E9PEE2 NCK2 Cytoplasmic protein NCK2 1 DAS(0.992)PT(0.007)PSTDAEYPANGSGADR;DAS(0.992)PT(0.007)PS(0.001)TDAEYPANGSGADR 332.37 5.146099999999998e-156 26922000.0 1236.26 1403.56 1681.81 1850.67 1653.44 1567.12 1567.1599999999999 1406.21 659.35 1253.26 True False 1265.0624526567888 1239.2305427026579 1453.429439521058 1527.4852258784301 1503.8866439385417 1551.356195631114 1448.9478594722445 1368.9127427861756 1118.86879298135 1414.1281287861714 0.8945882815743618 0.8763212593517687 1.0277919022575566 1.0801604145938033 1.0634726891610702 1.0970407589323137 1.0246227551643152 0.968025962372443 0.7912075081497321 1.0 10.465697127857375 -11.635323346769828 16.823955122324264 1.9006012204832428 0.9884450098965596 0.0 0.09454697377444701 0.23091711828404976 0.0015433628697003414 0.006618829040088033 0.024092125761840638 2.3156699142713018e-12 11.635323346769828 -0.9121562105866832 DAS(ph)PTPSTDAEYPANGSGADR ddPTM_A459_Selumetinib_30min_R2 2 DASPTPSTDAEYPANGSGADR 21 0 E9PEE2;E7EPF5;O43639 E9PEE2 NCK2 Cytoplasmic protein NCK2 1 DAS(1)PTPSTDAEYPANGSGADR;DAS(0.994)PT(0.006)PSTDAEYPANGSGADR 300.86 1.518299999999999e-101 50687000.0 54873.0 53401.0 60525.0 63656.0 57151.0 38536.0 39093.0 43673.0 35551.0 41817.0 True False 51823.378334023255 57496.68498872166 56630.887394637364 54985.942987275106 49971.1804435775 43843.984205021545 40910.901961309915 43800.08119954563 42662.19337793489 40609.63455638582 1.2761350576072614 1.415838522478907 1.3945185179149124 1.3540122581238208 1.2305252433186347 1.0796448843720787 1.0074186189611185 1.0785637861067163 1.0505436417729672 1.0 15.30953442414579 -6.591701998988487 2.0227319861752737 1.0389856526568557 1.3689860515380967 0.9335551836299048 0.04012066723037743 0.0752768644395632 0.6266462632874769 0.015201264456220864 0.01568573358819073 2.56034212112916e-07 6.591701998988487 0.330000398881241 DASLHGLSQYNS(ph)L ddPTM_A459_Selumetinib_30min_R1 1 DASLHGLSQYNSL 13 0 Q9Y4B5-4 Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 DASLHGLS(0.014)QY(0.216)NS(0.769)L 81.789 0.034349 15904000.0 2011.0 2436.4 2455.2 2463.4 3922.4 2440.2 2862.6 2256.9 383.87 1408.2 True False 2057.8523872751707 2151.145155348368 2121.7973254482376 2033.213433745035 3567.6196125559654 2415.6538035243284 2646.6717773075175 2197.039680555621 651.3993532444845 1588.9561870295754 1.2950969976851021 1.3538102390159412 1.3353403591415351 1.2795906207747378 2.24525990186384 1.5202771626071057 1.6656669321104791 1.3826936818584081 0.40995425711656824 1.0 10.633863629847832 -8.13678691808009 5.37705712363748 0.7163593496392593 1.5305510240015447 0.5394470453620135 0.29933903122072897 0.17165881097447938 6.625273950306461 0.21802138074774624 0.07916659642237873 7.298154985564131e-09 8.13678691808009 0.8141916743622855 DASLHGLSQYNS(ph)L ddPTM_A459_Selumetinib_30min_R2 1 DASLHGLSQYNSL 13 0 Q9Y4B5-4 Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 DASLHGLS(0.015)QY(0.172)NS(0.813)L 86.738 0.026068 15685000.0 58654.0 52737.0 80928.0 110390.0 112860.0 63133.0 59672.0 70171.0 71847.0 87161.0 True False 55394.24549056553 56781.75832381818 75721.18058774398 95354.69156662845 98681.51781879853 71828.99768568664 62446.86623782483 70375.18599256553 86218.40757290908 84644.43545852511 0.654434579077654 0.6708268300949405 0.8945795453364038 1.1265323119007775 1.1658358554136903 0.8485968072984797 0.7377551270741611 0.8314212932171854 1.018595104401815 1.0 16.36912760773813 -5.302641663479229 4.083202160815084 0.9522470150358295 0.6572736770917373 0.47042816442164226 0.12441761989398702 0.20712466580864333 7.595971269493452 0.03791377967722876 0.0910249836625454 4.981479374864653e-06 5.302641663479229 -0.2949733379440922 DASLSMLANCEK ddPTM_A459_Selumetinib_30min_R1 1 DASLSMLANCEK 12 0 G3V389;G3V424;Q4LDG9-3 G3V389 DNAL1 0 64.439 0.045867000000000005 6946400.0 10012.0 12552.0 10590.0 11136.0 11205.0 9986.9 11507.0 10329.0 5598.6 9176.6 False True 10245.260120039287 11082.406004733517 9151.936166706111 9191.306648609534 10191.509728403424 9886.440853379681 10639.017725661151 10055.041366679527 9500.415294434493 10354.505997653463 0.9894494360581825 1.0702978980595512 0.883860241017787 0.8876624969547042 0.984258421474962 0.954795994673251 1.0274770933613022 0.9710788104191739 0.9175150699210061 1.0 13.337971105320698 DASS(ph)SPASTASSASSTSLK ddPTM_A459_Selumetinib_30min_R1 2 DASSSPASTASSASSTSLK 19 0 A0A669KBK8;Q04724 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 DASS(0.5)S(0.5)PASTASSASSTSLK;DAS(0.036)S(0.482)S(0.482)PASTASSASSTSLK 330.65 1.2717999999999992e-154 157520000.0 10981.6 12488.4 14633.9 14226.7 12869.3 11312.8 12250.8 11547.0 6723.1 10486.3 True False 11237.449913526109 11026.25232230035 12646.696758258784 11742.27391323395 11705.274087259453 11199.003503200562 11326.71229282433 11240.736050057943 11408.609664204001 11832.318750211782 0.9497250835407873 0.9318758693939847 1.068826577887147 0.9923899246733681 0.9892629107080085 0.9464758125283023 0.9572690300133774 0.9500028090315561 0.9641905280822327 1.0 13.530445202308305 -6.744188241580802 24.230517358931067 0.9600679004101385 0.988296316617485 0.0855251814981336 0.03616528134756127 391.56736232566743 549983.4476313655 0.012480269723708868 0.012448259018489735 1.802236406123031e-07 6.744188241580802 0.028228416207346507 DASS(ph)SPASTASSASSTSLK ddPTM_A459_Selumetinib_30min_R2 2 DASSSPASTASSASSTSLK 19 0 A0A669KBK8;Q04724 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 DASS(0.5)S(0.5)PASTASSASSTSLK;DAS(0.001)S(0.5)S(0.5)PASTASSASSTSLK 327.7 1.8246999999999996e-154 109537000.0 101228.0 92540.0 106388.0 111170.0 113774.0 81116.0 84277.0 90843.0 74403.0 93780.0 True False 95602.15300779084 99637.52043700148 99543.11190649612 96028.45422105321 99480.69296753476 92288.99270226623 88196.04749170729 91107.33809013173 89285.67899351625 91072.32773029762 1.0497387668722806 1.0940482462693706 1.0930116138162622 1.0544196751556927 1.092326236155265 1.0133593266175391 0.9684176268437085 1.0003844236850714 0.9803820899134986 1.0 16.474725138177313 -6.893682077398976 4.283756979030848 0.987643718091625 1.0771766195034143 0.864120210043811 0.016907931941305063 0.07219444493343886 2.3655467629272415 0.005940678408312799 0.005209350427746275 1.2773735600785347e-07 6.893682077398976 0.08953290141178927 DASSS(ph)PASTASSASSTSLK ddPTM_A459_Selumetinib_30min_R1 2 DASSSPASTASSASSTSLK 19 0 A0A669KBK8;Q04724 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 DASSS(1)PASTASSASSTSLK;DASS(0.003)S(0.996)PAS(0.001)TASSASSTSLK 234.36 3.5745e-24 23307000.0 8254.3 9370.3 9326.2 9221.8 9187.2 7708.700000000001 8886.4 7255.6 4219.0 6649.2 True False 8446.609129928116 8273.220919865715 8059.753265149624 7611.3857446253 8356.219382131902 7631.157476939593 8216.09169351831 7063.1579184896855 7159.334856431809 7502.689588692695 1.1258108215829696 1.1027006811443043 1.0742485304598606 1.0144876253572346 1.1137631756384485 1.0171229112877749 1.0950861816142285 0.9414167859396145 0.9542357806221444 1.0 12.873192155028256 -7.761608826793235 24.999999991585895 0.9608696917373113 1.075076264030737 0.6501516429706227 0.03770683252764331 2.734488888294926 403195.7846855011 0.01904828118190123 0.01005792338980734 1.7313751232983756e-08 7.761608826793235 0.11420657229342568 DASSS(ph)PASTASSASSTSLK ddPTM_A459_Selumetinib_30min_R2 2 DASSSPASTASSASSTSLK 19 0 A0A669KBK8;Q04724 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 DASS(0.001)S(0.999)PASTASSASSTSLK;DAS(0.001)S(0.01)S(0.989)PASTASSASSTSLK 278.88 1.5082999999999996e-71 102676000.0 90073.0 82555.0 93228.0 103998.0 106903.0 72756.0 84876.0 89128.0 69298.0 84242.0 True False 85067.10325078778 88886.70304383666 87229.81197897135 89833.2929934436 93472.88941505423 82777.47858679021 88822.9021786033 89387.34772406534 83159.53634789829 81809.71457299807 1.0398166488514413 1.0865054780813819 1.0662524913363067 1.0980761082265622 1.1425646685473914 1.0118294510480002 1.0857256090210097 1.0926251019285225 1.0164995292056151 1.0 16.319984547094634 -8.359126281157154 4.568749013667711 1.001886076834128 1.078645545290127 0.41689442084781025 0.03310548673677637 0.21549614898658845 7.101281155969811 0.031436083557515634 0.008275097981080108 4.37394903989282e-09 8.359126281157154 0.0767594684559989 DASVPLIDVTNLPT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 DASVPLIDVTNLPTPR 16 0 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 DASVPLIDVTNLPT(1)PR 159.14 0.00014909 2855500.0 1414.2 1810.8 1808.1 1797.0 1561.5 1520.0 1804.2 1498.6 1120.9 1786.5 True False 1447.148108445822 1598.7906941819185 1562.569951182372 1483.1876838677554 1420.2626007052156 1504.7101800495761 1668.107741430246 1458.8522598611605 1902.0854327031086 2015.8146769836217 0.7178973965063455 0.7931238483560801 0.7751555582086219 0.7357758135222696 0.7045601051136484 0.7464526363609773 0.8275104653600056 0.7237035609067617 0.9435814980518484 1.0 10.977147296076138 -8.364808685365372 3.983144087442764 0.9963103231523721 0.7550849893921099 0.8554981016053776 0.03618187074081871 0.07943440889591397 2.086673804250838 0.035209193089995185 0.009339903061222735 4.3170921072152205e-09 8.364808685365372 -0.24122533376026223 DASVPLIDVTNLPT(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 DASVPLIDVTNLPTPR 16 0 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 DASVPLIDVTNLPT(1)PR;DASVPLIDVTNLPT(1)PR 191.36 2.4721e-06 8415800.0 36447.0 33724.0 36658.0 41276.0 41330.0 37497.0 41392.0 37887.0 34215.0 40700.0 True False 34421.42164890105 36310.522360248884 34299.464190212595 35654.13759492848 36137.75590511202 42661.87138612447 43316.81001669198 37997.244897469485 41058.95604697596 39524.88524870036 0.8708797364574987 0.9186749596304731 0.8677941497968148 0.9020680862343766 0.9143038791314463 1.079367368625751 1.0959376540660877 0.9613499105280487 1.0388127831016547 1.0 15.270473653610104 -6.672046855281464 5.818685757196274 1.0361248231899995 0.8928590934150638 0.7748409070221105 0.03792967648501262 0.10160649147815075 5.274535303604932 0.013121261132755014 0.013044037507515701 2.127909457122325e-07 6.672046855281464 -0.1432657297749358 DAT(ph)PPVS(ph)PINMEDQER ddPTM_A459_Selumetinib_30min_R2 1 DATPPVSPINMEDQER 16 0 P17275 P17275 JUNB Transcription factor jun-B 2 DAT(1)PPVS(1)PINMEDQER 169.58 0.0018969 2400900.0 19533.0 12231.0 11919.0 14189.0 13079.0 10252.0 12936.0 10787.0 9410.0 11461.0 True False 18447.434056794347 13169.078371136391 11152.144516425984 12256.433722609752 11435.899092256477 11664.11994160995 13537.549632197713 10818.38838411602 11292.262937367937 11130.09115074582 1.6574378239084049 1.183195913921508 1.0019814182454998 1.1011979647433936 1.027475780509683 1.0479806304936097 1.2163017758655617 0.9719945899446732 1.0145705712941309 1.0 13.442177787340777 -4.7677049295111384 2.89115778844432 1.0544283287576866 1.77491384740971 0.8840897184275271 0.06614916704182837 0.13258440249377504 1.5148247017131315 0.01695147289229451 0.23110792815455672 1.7072419377436212e-05 4.7677049295111384 0.7204855186520234 DAT(ph)PPVSPINMEDQER ddPTM_A459_Selumetinib_30min_R1 1 DATPPVSPINMEDQER 16 0 P17275 P17275 JUNB Transcription factor jun-B 1 DAT(1)PPVSPINMEDQER 150.12 0.0014831 0.0 801.13 792.83 710.14 1009.0 717.02 575.11 806.14 571.93 366.08 589.63 True False 819.7947702723811 700.0050950233325 613.7068885197996 832.797091275774 652.165667600163 569.3249155581 745.3322107729625 556.760558509538 621.2110225746753 665.314753982566 1.2321908771225945 1.0521412471812936 0.9224309018342937 1.2517339894999484 0.9802362922155375 0.8557226668281862 1.1202700771498197 0.8368378352904037 0.9337099754005359 1.0 9.377893216973606 -6.500423760702602 24.18422701444783 0.9462604632089334 1.0988771159704027 0.32399094859751965 0.11311520365944082 648.6180337210712 698568.1857389072 0.0346499781813862 0.03895933933389324 3.159193588188686e-07 6.500423760702602 0.1526166527614693 DAT(ph)PPVSPINMEDQER ddPTM_A459_Selumetinib_30min_R2 2 DATPPVSPINMEDQER 16 0 P17275 P17275 JUNB Transcription factor jun-B 1 DAT(1)PPVSPINMEDQER;DAT(0.999)PPVS(0.001)PINMEDQER 164.53 5.5896e-05 8156000.0 42168.0 34732.0 36448.2 37054.0 30792.0 22391.3 30533.0 24593.9 24325.1 26357.4 True False 39824.471371878564 37395.83271901803 34103.16249379963 32007.1812782847 26923.633676027348 25475.498327016263 31952.844999991714 24665.464177260685 29190.799700081676 25596.3933772505 1.555862608646797 1.4609805439329826 1.3323424902552778 1.2504566876492829 1.0518526293613095 0.9952768716884275 1.2483338777091417 0.9636304542491833 1.1404262807597654 1.0 14.643652923238923 -5.6207194305062185 1.1294464835462954 1.066066977903366 1.5586783357538139 0.8255104566550868 0.0814739646250775 0.23503870560467469 0.5467720478967812 0.028312905631453698 0.0979235377008126 2.394862422016984e-06 5.6207194305062185 0.49261135785044785 DATNVGDEGGFAPNILENK ddPTM_A459_Selumetinib_30min_R1 2 DATNVGDEGGFAPNILENK 19 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 0 ; 349.54 5.064199999999996e-193 37392000.0 8494.1 8917.6 7953.6 8770.099999999999 8320.5 7967.0 8100.7 7354.7 6113.5 7724.299999999999 False True 8691.996003358547 7873.523246320238 6873.544805997523 7238.566670166168 7567.912244103586 7886.859213457226 7489.657677089011 7159.629464567516 10374.162987626423 8715.789146053508 0.9972701103369699 0.9033632083545015 0.7886313781592399 0.8305119076272945 0.8682991427724386 0.9048933012598612 0.8593206595045169 0.8214551022966614 1.190272368202462 1.0 13.089415579598866 -8.25404120719917 24.993872922961113 1.0951361899332113 0.8692084638894293 0.627842462352534 0.0687827112572219 314.1439260954813 1061308.4970178932 0.04819772757300181 0.01739664021657097 5.571328839385634e-09 8.25404120719917 -0.22592772604378197 DATNVGDEGGFAPNILENK ddPTM_A459_Selumetinib_30min_R2 4 DATNVGDEGGFAPNILENK 19 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 0 ;;; 268.93 1.8636e-57 50616000.0 206889.0 175453.0 192361.0 209660.0 195590.0 157540.0 163198.0 165380.0 134264.0 184370.0 False True 195390.93762228693 188909.68092968655 179984.7026868206 181103.94631632665 171018.23560321474 179239.70499426767 170787.0303707021 165861.2284198672 161120.55164960347 179046.75904921076 1.0912844145287433 1.055085732536298 1.0052385401589539 1.0114896649235101 0.9551596270793743 1.0010776288053551 0.9538683150570825 0.9263570549985798 0.8998797437339802 1.0 17.449976878903968 -4.823468300387306 0.4831161449927881 0.941276365035519 1.1930684961235325 0.7205043763514634 0.029006218127396562 2.371744555044075 0.440544350819486 0.019595837025499118 0.341105492304348 1.5015219994302192e-05 4.823468300387306 0.25179213108801346 DAVAHCHEAER ddPTM_A459_Selumetinib_30min_R1 1 DAVAHCHEAER 11 0 P49792;H0YBN8;Q99666;O14715;J3KQ37;F8W705;Q99666-2 P49792;Q99666 RANBP2;RGPD8;RGPD5 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 0 97.452 0.010844 374830.0 711.66 544.69 525.1 429.64 483.58 548.86 443.84 398.11 394.16 423.27 False True 728.2402933506953 480.9174415804889 453.79430416783595 354.6114393416486 439.84027438298324 543.3389667250073 410.3607914623658 387.5508295564707 668.8607316926199 477.60082749894076 1.5247885921058426 1.0069443223097336 0.9501539319858955 0.7424849768344153 0.9209370023211669 1.1376424315894056 0.8592128987952307 0.8114534298149436 1.4004597420721665 1.0 8.899661526016438 -4.760530374763206 4.5556117336073765 0.9628759432115924 1.5713028761521501 0.46288622133004786 0.17537877819010242 0.17664790570798358 8.228483743633632 0.04305485813277751 0.3533748770172548 1.735679864348598e-05 4.760530374763206 0.6084269329405577 DAVAHCHEAER ddPTM_A459_Selumetinib_30min_R2 1 DAVAHCHEAER 11 0 P49792;H0YBN8;Q99666;O14715;J3KQ37;F8W705;Q99666-2 P49792;Q99666 RANBP2;RGPD8;RGPD5 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 0 79.23 0.025989 1150500.0 12226.0 9125.5 8513.7 9543.7 11153.0 9102.1 15014.0 20620.0 14627.0 16547.0 False True 11546.527864555765 9825.39650689275 7965.937811015683 8243.831596199212 9751.860430914938 10355.831654362843 15712.180749676592 20680.00078617524 17552.808712527174 16069.245115730839 0.7185482442639697 0.6114410749310352 0.4957257017143576 0.5130192200583827 0.6068648751501367 0.6444504131824523 0.9777796428218833 1.2869304461558522 1.092323166776765 1.0 13.972014536728498 -7.332475199178293 2.800642328931986 1.1430413570299254 0.5838873232109968 0.8817781369902603 0.0891655399813218 0.08416255650915787 1.294942337189188 0.042323849279132665 0.02711279739289926 4.6507693409278485e-08 7.332475199178293 -0.5591540338189286 DAVCS(ph)GVTGAANVAK ddPTM_A459_Selumetinib_30min_R1 1 DAVCSGVTGAANVAK 15 0 A0A0J9YXN7;Q96Q06;Q96Q06-2 A0A0J9YXN7 PLIN4 Perilipin-4 1 DAVCS(0.679)GVT(0.321)GAANVAK 90.827 0.024999 0.0 1407.2 1110.0 1357.0 1565.2 1323.9 1426.7 1161.7 1227.4 819.02 741.73 True False 1439.9850220654505 980.0406839750002 1172.7268534674408 1291.8672024428558 1204.1534787535288 1412.3486933399547 1074.0720337099638 1194.8453648429124 1389.8171211459542 836.9382705620275 1.7205391039155853 1.1709832354982113 1.4012106922532315 1.5435633043466048 1.4387602062275227 1.6875183547187094 1.2833348306425207 1.4276385808484302 1.660596928149376 1.0 9.70897740868152 -10.880458197044375 6.502175267270417 0.9999687908539068 1.4692777915981086 0.42223977568549553 0.16844442516848862 7.345929801745514e-05 7.257865109356447e-06 0.1572073531700893 0.03812585637685175 1.3168666614408146e-11 10.880458197044375 0.4693090007442018 DAVTYTEHAK ddPTM_A459_Selumetinib_30min_R1 2 DAVTYTEHAK 10 0 P62805 P62805 HIST1H4A Histone H4 0 ; 151.15 0.00095962 95174000.0 18100.1 12766.2 18805.5 17194.699999999997 13595.6 15031.0 14496.7 17864.7 6023.3 9573.3 False True 18521.797113336313 11271.52736915463 16251.816391217357 14191.968429494089 12365.880380498142 14879.801787056056 13403.202247639865 17390.870123276185 10221.10017557377 10802.126306838687 1.714643634708326 1.0434545059909892 1.5045016073297108 1.3138124871312915 1.1447635427730058 1.3774882244837154 1.2407929575082335 1.6099487850152474 0.9462118739625294 1.0 13.399027702159957 -14.138924799192257 0.12966251203827345 1.2010489638207655e-09 1.4639248276420453 0.22510103989675467 0.21980831248992802 216.11990793976113 1.9386104686535772 56.65628341197767 1.6226000121605129 7.262316981123811e-15 14.138924799192257 1.4639248264409963 DAVTYTEHAK ddPTM_A459_Selumetinib_30min_R2 2 DAVTYTEHAK 10 0 P62805 P62805 HIST1H4A Histone H4 0 ; 156.16 0.00072128 13313600.0 127603.0 105993.0 136926.0 153198.0 82352.0 82408.0 277640.0 74148.0 97500.0 197814.0 False True 120511.33609528119 114122.32227878836 128116.33023375637 132332.16811870973 72006.20552377895 93758.95397465791 290550.8101332232 74363.75840413776 117002.72437761699 192102.59583750367 0.627327994033041 0.594069652110909 0.6669161844232849 0.6888619466165219 0.37483202769778173 0.48806708501725304 1.5124772721915491 0.38710439117148004 0.6090637342380715 1.0 17.55151748837305 DCCVEPGTELS(ph)PTLPHQL ddPTM_A459_Selumetinib_30min_R1 1 DCCVEPGTELSPTLPHQL 18 0 Q14012 Q14012 CAMK1 Calcium/calmodulin-dependent protein kinase type 1 1 DCCVEPGT(0.004)ELS(0.853)PT(0.143)LPHQL 97.223 0.0035674 5252100.0 1196.4 1388.5 868.9 1458.3 2711.7 831.16 1803.2 1553.0 438.98 669.46 True False 1224.273792210848 1225.9337745038629 750.908152526057 1203.635280681329 2466.4272137895186 822.7992850328989 1667.1831722353502 1511.8093951450576 744.9169981693382 755.3917120926147 1.6207138264984642 1.622911338420347 0.9940645899408439 1.5933922247398942 3.2650970010736926 1.0892352561739778 2.2070445644907277 2.001358197268257 0.9861334010479688 1.0 9.561081144868037 -6.006181827115432 24.974754793236706 1.8546696166690133 1.4102863880634975 0.03978572487769194 0.6684628473997482 744.6993059383165 3008632.4697391656 0.18642442773204312 0.2662878748464434 9.858666440551885e-07 6.006181827115432 -0.4443832286055158 DCDLQEDACYNCGR ddPTM_A459_Selumetinib_30min_R2 2 DCDLQEDACYNCGR 14 0 P62633-2;P62633;P62633-7;P62633-3 P62633-2 CNBP Cellular nucleic acid-binding protein 0 ; 236.08 5.3703999999999994e-14 18869500.0 43537.0 35949.0 36085.0 40550.0 41134.0 35367.0 49931.0 55441.0 43904.0 36712.0 False True 41117.38783241977 38706.172705746256 33763.33038637736 35027.02004734833 35966.379177374285 40238.48322033933 52252.89043639948 55602.32413124836 52686.026780255255 35652.02917076878 1.1532972677508089 1.0856653493788113 0.9470240873150646 0.9824691851219257 1.0088171701279556 1.1286449651323354 1.4656358039570383 1.5595837158362054 1.4777847995101696 1.0 15.121696570981406 -7.143010174212944 3.851105768385323 1.4219631821992524 1.0331108858624374 0.5196635491079559 0.15209357570745805 0.16667746466906247 4.350547943848022 0.05921994728753224 0.04495215888424198 7.194321236763492e-08 7.143010174212944 -0.38885229633681506 DCDPGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 DCDPGSPR 8 0 Q00341;Q00341-2;A0A024R4E5;H0Y394 Q00341 HDLBP Vigilin 1 DCDPGS(1)PR 117.01 0.0090683 5514000.0 4449.3 6742.6 6714.9 5356.0 5850.3 6365.3 5544.1 6454.1 4974.6 5339.4 True False 4552.9600331692745 5953.173257450304 5803.0534623054655 4420.675144571899 5321.141397954354 6301.270861229986 5125.904073419484 6282.916302128602 8441.532869591298 6024.764000160287 0.7557076149452733 0.9881172536039456 0.9632001290259796 0.7337507567855419 0.8832115909955621 1.0458950526630326 0.8508057864645173 1.042848533479726 1.4011391764667818 1.0 12.556689014391937 -8.001564108878734 5.617076485468987 1.209942686624203 0.8975516020848823 0.48758455590896055 0.12836607630923685 0.12450181129842877 13.96336823007241 0.0763951989591022 0.032262844912101456 9.964049838120819e-09 8.001564108878734 -0.31239108453932063 DCDPGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 DCDPGSPR 8 0 Q00341;Q00341-2;A0A024R4E5;H0Y394 Q00341 HDLBP Vigilin 1 DCDPGS(1)PR 82.287 0.044095 0.0 16158.0 10492.0 10546.0 14558.0 14037.0 13289.0 21891.0 34425.0 16910.0 29387.0 True False 15260.0030455989 11296.702662902717 9867.481841616618 12575.175286049247 12273.54656762781 15119.439124468841 22908.97487619358 34525.17105063445 20292.47250487691 28538.520953404364 0.5347159746125011 0.3958405090911038 0.34576009940135055 0.44063864790263957 0.4300694695309253 0.5297905644498806 0.8027386883012508 1.2097743645161099 0.7110555076771146 1.0 14.800622946721862 -7.299846176419703 2.6348833537551606 0.9754022507792143 0.42785408884714804 0.7935792601283373 0.12351018031811613 0.11536285178913927 1.5823420707303844 0.054820795867053705 0.03566528154252516 5.0136478151841204e-08 7.299846176419703 -0.5475481619320662 DCEYQQISPGAAPLPAS(ph)PGAR ddPTM_A459_Selumetinib_30min_R1 1 DCEYQQISPGAAPLPASPGAR 21 0 Q9NUE0 Q9NUE0 ZDHHC18 Palmitoyltransferase ZDHHC18 1 DCEYQQIS(0.002)PGAAPLPAS(0.998)PGAR 68.952 0.038297000000000005 0.0 320.89 198.3 425.19 283.92 426.4 286.04 309.9 339.62 158.39 237.18 True False 328.3661126567525 175.08294381283113 367.45153340148914 234.33870183847142 387.8321952870342 283.16269730354026 286.5239934980784 330.6121743587663 268.7762616521058 267.6243633288417 1.2269664412177406 0.6542115285584037 1.3730122655162955 0.8756254435270875 1.4491662510206065 1.058060237048022 1.0706199911478684 1.2353590317654628 1.004304160910226 1.0 8.064065648256914 -5.2708079081073596 24.999533479991435 1.1388311692968038 0.9405889671208173 0.11795937365259523 0.21031310220370417 1143.0401255108848 3050160.8636151133 0.05026181371969906 0.10695965734047821 5.360336970413791e-06 5.2708079081073596 -0.19824220217598654 DCEYQQISPGAAPLPAS(ph)PGAR ddPTM_A459_Selumetinib_30min_R2 2 DCEYQQISPGAAPLPASPGAR 21 0 Q9NUE0 Q9NUE0 ZDHHC18 Palmitoyltransferase ZDHHC18 1 DCEYQQISPGAAPLPAS(1)PGAR;DCEYQQISPGAAPLPAS(1)PGAR 189.51 1.4862999999999999e-16 7428400.0 43359.0 18791.5 33588.0 37121.0 30939.0 24371.5 51903.0 36230.0 28876.0 24666.7 True False 40949.280359829325 20232.747625804062 31426.984647849335 32065.055762703232 27052.16622183065 27728.452902550423 54316.59234384335 36335.42330180062 34652.00686285191 23954.508279216643 1.7094602770601495 0.8446321414728581 1.3119444691384436 1.3385812553089826 1.1293141944934677 1.157546319855295 2.267489347337987 1.5168511446058728 1.4465755864801702 1.0 14.548009578725589 DCGATWVVLGHSER ddPTM_A459_Selumetinib_30min_R1 4 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 ;;; 157.86 0.00043568 142067000.0 18781.3 20340.9 21476.7 22018.699999999997 21377.4 19651.1 21896.7 18866.3 12094.7 15748.999999999998 False True 19218.867747951845 17959.37797177215 18560.282103068654 18173.547387189174 19443.817944486524 19453.427775771215 20245.014289865685 18365.904437620855 20523.822538062526 17770.537558250802 1.0815017657712098 1.0106266010750853 1.044441229885653 1.0226785389928317 1.0941603696990485 1.0947011429453946 1.1392460258168156 1.0335030314878475 1.1549353794608979 1.0 14.117199703059686 -6.269724499043898 24.401665431340867 1.0908544054357299 1.0380580169527518 0.1925347558445798 0.04575441653075037 617.3332282462438 1818188.2186319125 0.013088218878473869 0.01508818539010081 5.373725782991853e-07 6.269724499043898 -0.052796388482978074 DCGATWVVLGHSER ddPTM_A459_Selumetinib_30min_R2 3 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 ;; 144.68 0.00074161 87815900.0 247833.0 214532.0 243117.0 256028.0 287527.0 201825.0 206596.0 234192.0 189757.0 243584.0 False True 234059.43401410535 230985.91457089692 227475.11690577568 221156.54472706537 251405.28773600637 229624.56176506344 216203.12336220793 234873.45994742747 227713.70225357314 236551.0970127628 0.9894667028387402 0.9764736561692393 0.9616320523489373 0.9349208163474853 1.0627948502916567 0.9707186509165686 0.9139806413603019 0.9929079294642003 0.9626406519741786 1.0 17.851792325843157 -4.787833686103233 4.572803726614049 0.9737934020153672 0.9903472446579719 0.012072689307939366 0.03787497597493155 1.2125520477110492 54.90555393660341 0.009594706037745995 0.061861673676268596 1.629920094135335e-05 4.787833686103233 0.01655384264260462 DCHEEVYAGSHQYPGR ddPTM_A459_Selumetinib_30min_R1 1 DCHEEVYAGSHQYPGR 16 0 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 0 156.2 4.8205e-05 4802900.0 888.99 1516.5 1465.1 1373.6 1399.5 1293.4 1328.9 1210.2 685.05 1039.3 False True 909.7017373265805 1338.947474998277 1266.1474672182362 1133.7265456654136 1272.9154721017937 1280.3895703132384 1228.6600030964723 1178.1015647163863 1162.4798159276163 1172.7042786392826 0.7757298697520996 1.1417605438874072 1.0796818006730375 0.9667625217338716 1.0854530807875866 1.0918264677936587 1.0477151192132739 1.0046024272064278 0.991281294953976 1.0 10.195623538839648 -4.748763204214287 24.996621474012624 1.046977845771034 0.7757292329654664 0.7073168585736191 0.05204307808292419 345.8403571072256 681934.5832160753 0.013316856316011526 0.2351996128138139 1.7833508609966772e-05 4.748763204214287 -0.27124861280556756 DCLCQLCAQPMSS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 DCLCQLCAQPMSSSPK 16 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;A0A494C1P1;A0A494C1G0 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 DCLCQLCAQPMSS(0.958)S(0.042)PK 182.7 9.0591e-07 10202000.0 1814.3 2112.7 1772.2 1869.1 1526.8 1765.4 1803.9 1867.4 1215.2 1870.9 True False 1856.5696599867442 1865.3441018324154 1531.5449739977878 1542.6967723523765 1388.701209578433 1747.6416788549495 1667.8303706717772 1817.870485829929 2062.1056453036103 2111.0482391092423 0.8794539251126372 0.8836103634559759 0.7254902780639555 0.7307728661867613 0.6578254271273289 0.8278549236716484 0.7900484412310346 0.8611221914080847 0.9768159756376371 1.0 11.043743830437887 -8.116602672281271 1.781599852906365 1.0037446366138112 0.7790363318971288 0.60134317685386 0.0658126753752152 0.27035761700958333 1.529702170770002 0.06585894500473975 0.02057018420384931 7.64534922098678e-09 8.116602672281271 -0.22470830471668235 DCLCQLCAQPMSS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 DCLCQLCAQPMSSSPK 16 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;A0A494C1P1;A0A494C1G0 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 DCLCQLCAQPMSS(0.684)S(0.316)PK 163.44 0.00012117 2997500.0 14019.0 14257.0 13856.0 14302.0 11100.0 7758.2 13089.0 13171.0 6895.0 9833.1 True False 13239.880102503452 15350.46605651964 12964.520045272126 12354.042927673867 9705.518764740951 8826.821628072406 13697.664435361452 13209.325429423578 8274.192662396588 9549.19285353798 1.386492063315914 1.6075145084992484 1.3576561123141173 1.293726403598257 1.0163705889702555 0.9243526404225951 1.4344316473079148 1.3832923506754309 0.8664808418159653 1.0 13.221163079024091 -5.800305589748793 2.267786773948386 1.1333080131670838 1.4893823236736135 0.4172128027382609 0.18332386414970944 0.3201884884194638 3.3605405251319502 0.05772670736123446 0.1050684410746405 1.5837783803343956e-06 5.800305589748793 0.3560743105065296 DCLCQLCAQPMSSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 DCLCQLCAQPMSSSPK 16 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;A0A494C1P1;A0A494C1G0 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 DCLCQLCAQPMSS(0.079)S(0.921)PK 229.69 3.1486e-15 12263000.0 58768.0 44964.0 40247.0 36485.0 42450.0 34815.0 44310.0 49919.0 28257.0 39190.0 True False 55501.909826943665 48412.59421795249 37657.55183762031 31515.680059864437 37117.051492185004 39610.45023089646 46370.502798599286 50064.256025464696 33909.18956654685 38058.482872151566 1.4583321677164365 1.2720579109940642 0.9894653962986888 0.8280855588945539 0.975263559949852 1.0407784872549533 1.2184012419614827 1.3154559048936258 0.8909758615564555 1.0 15.215930432058705 -5.029122629692503 3.203630232325442 1.0420893172547492 1.4454150232396792 0.5088747995427225 0.13613385588055255 0.23094262830970302 4.610614856664125 0.03937144105122845 0.1715354094324986 9.351415853284724e-06 5.029122629692503 0.40332570598493 DCNS(ph)ESEVTK ddPTM_A459_Selumetinib_30min_R2 2 DCNSESEVTK 10 0 Q92628 Q92628 KIAA0232 Uncharacterized protein KIAA0232 1 DCNS(0.945)ES(0.028)EVT(0.027)K;DCNS(0.975)ES(0.025)EVTK 152.0 0.0006502999999999999 3513500.0 38883.0 33657.0 50048.0 49524.0 48277.0 41039.0 39763.0 41428.0 34459.0 40546.0 True False 36722.038520981674 36238.383675687845 46827.96616814231 42778.74576633484 42212.01165814403 46691.74973504979 41612.05828888975 41548.5486212254 41351.762864905606 39375.33162884043 0.9326153457482158 0.920332151542949 1.1892716640345247 1.0864351866182527 1.0720420606496144 1.1858122282035704 1.0568052780134816 1.055192347657415 1.050194656255734 1.0 15.265004453837143 -5.239278213380676 24.888076535890683 1.0908409766107166 0.926473692346513 0.566159702130695 0.056115819958140814 522.089821882189 586330.3504756441 0.014089652161150575 0.037208933639677186 5.763970993597073e-06 5.239278213380676 -0.16436728426420355 DCS(ph)PTCWEQGK ddPTM_A459_Selumetinib_30min_R1 2 DCSPTCWEQGK 11 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 DCS(0.5)PT(0.5)CWEQGK;DCS(0.752)PT(0.248)CWEQGK 187.78 1.9372e-05 35939000.0 11762.9 13334.699999999999 13336.599999999999 13764.2 12077.599999999999 11339.6 10737.8 10959.8 6419.3 9832.2 True False 12036.952683380958 11773.467124866153 11525.56297269998 11360.5408560337 10985.183212473466 11225.533919533018 9927.839100947618 10669.11050155235 10893.083252878101 11094.258643738243 1.0849713414762314 1.0612216194825477 1.0388763542307689 1.0240018031710258 0.990168299228688 1.011832721771713 0.8948627772033267 0.9616785442057588 0.9818667116640832 1.0 13.43752564449428 -5.98637556134198 0.8544362030531862 0.9601816445079199 1.0810290919803869 0.6664570983025617 0.029391034983426653 0.41935097496450935 0.6122526741240841 0.014183425508296748 0.03386593175009827 1.0318686990418314e-06 5.98637556134198 0.120847447472467 DCS(ph)PTCWEQGK ddPTM_A459_Selumetinib_30min_R2 3 DCSPTCWEQGK 11 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 DCS(0.868)PT(0.132)CWEQGK;DCS(0.947)PT(0.053)CWEQGK;DCS(0.995)PT(0.005)CWEQGK 171.26 0.00031600000000000004 57121000.0 195509.0 204652.0 184494.0 208571.0 228875.0 159534.0 199788.0 200944.0 152286.0 197592.0 True False 184643.39246453712 220348.15034010354 172623.8569018794 180163.26999495612 200121.67633153943 181508.36039453774 209078.53787241137 201528.71377193008 182747.45522635628 191887.00555432978 0.9622506325070472 1.1483224187253025 0.8996120211642141 0.9389029208856237 1.0429141658311936 0.9459127254093634 1.089591956831147 1.0502468011825346 0.9523701445985315 1.0 17.549897491040035 -7.244598897396443 24.84672919589955 1.0272394728044065 0.9928861968803789 0.046489219822879346 0.07224064322653188 2764.1395499589817 4078265.8320728717 0.027877434014005668 0.021518495738661617 5.693785506677814e-08 7.244598897396443 -0.03435327592402759 DCSYGAVTS(ph)PTSTLESR ddPTM_A459_Selumetinib_30min_R1 2 DCSYGAVTSPTSTLESR 17 0 Q9HCD6;Q9HCD6-2;Q9HCD6-3;Q9HCD6-4;J3KRP9 Q9HCD6 TANC2 Protein TANC2 1 DCSYGAVT(0.227)S(0.534)PT(0.21)S(0.023)T(0.006)LESR;DCSYGAVT(0.259)S(0.536)PT(0.205)S(0.001)TLESR 199.33 5.8337e-08 85175000.0 6741.9 7639.8 8755.4 8888.2 8977.9 7241.299999999999 8086.200000000001 8095.0 4653.4 6622.799999999999 True False 6898.973152546234 6745.328664353335 7566.464769969655 7336.042722177737 8165.850530176981 7168.459096574341 7476.251423763035 7880.294303734218 7896.479929111113 7472.900891534925 0.9231988022698362 0.9026385820256546 1.0125204227638984 0.9816860719359711 1.092728332504317 0.9592605603393661 1.0004483576427334 1.0545160999874594 1.0566820092657734 1.0 12.86745267351636 -5.290531527501043 5.928117553054818 1.0204450263560794 0.9125633145012279 0.5654462987730074 0.03745693022243611 0.11791170214326503 13.898241810249838 0.009911485784062177 0.022054079353516484 5.122340834075344e-06 5.290531527501043 -0.10788171185485151 DCSYGAVTS(ph)PTSTLESR ddPTM_A459_Selumetinib_30min_R2 4 DCSYGAVTSPTSTLESR 17 0 Q9HCD6;Q9HCD6-2;Q9HCD6-3;Q9HCD6-4;J3KRP9 Q9HCD6 TANC2 Protein TANC2 1 DCSYGAVT(0.215)S(0.518)PT(0.218)S(0.043)T(0.005)LESR;DCSYGAVT(0.196)S(0.389)PT(0.389)S(0.024)T(0.003)LESR;DCSYGAVT(0.192)S(0.382)PT(0.382)S(0.039)T(0.004)LESR;DCS(0.001)YGAVT(0.114)S(0.603)PT(0.165)S(0.112)T(0.005)LESR 237.34 2.0407e-22 110459500.0 138870.0 117466.0 138236.0 135421.0 130662.0 91227.0 108080.0 108445.0 89038.0 109582.0 True False 131152.16134065576 126475.26448727882 129342.0462599767 116976.42618574473 114247.07142689926 103792.69117374654 113105.9341564571 108760.55699596378 106848.08792958206 106418.08293177096 1.2324236419927133 1.1884753136209694 1.2154141730113974 1.0992156874386017 1.0735682158468105 0.975329458249049 1.0628450639255924 1.0220119926957778 1.0040407136265252 1.0 16.699383793879015 -6.020714921773845 1.5311251325591733 1.0179405420544716 1.21748581484496 0.9050529720949836 0.027559111565939775 0.106708018318081 0.5048894561671043 0.009175601242450735 0.0155732585348491 9.534218008198977e-07 6.020714921773845 0.1995452727904885 DDAT(ph)PVRDEPMDAESITFK ddPTM_A459_Selumetinib_30min_R1 3 DDATPVRDEPMDAESITFK 19 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 DDAT(1)PVRDEPMDAESITFK;DDAT(1)PVRDEPMDAESITFK;DDAT(1)PVRDEPMDAESITFK 105.51 0.0011917 58549000.0 9707.7 11751.7 6881.900000000001 7311.8 8702.5 8339.400000000001 9893.900000000001 8666.9 4473.21 9432.2 True False 9933.870522104022 10375.805500782884 5947.375779570806 6034.9313894848365 7915.360411551165 8255.513207569375 9147.59515737541 8437.025657941207 7590.7106596680105 10642.914747408298 0.9333787555258827 0.9749026227340157 0.558810807069471 0.567037464145283 0.7437211139437783 0.7756816063550364 0.8595009332009336 0.7927363751547237 0.7132172755134073 1.0 13.377605691644197 -10.021745000904758 9.642852014509508 0.9999999693775189 0.7655691701249744 0.22332051207723536 0.12923852492378443 0.0 0.0 0.13689390989165137 0.03320164999923912 9.511631119190695e-11 10.021745000904758 -0.2344307992525445 DDAT(ph)PVRDEPMDAESITFK ddPTM_A459_Selumetinib_30min_R2 2 DDATPVRDEPMDAESITFK 19 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 DDAT(1)PVRDEPMDAESITFK;DDAT(1)PVRDEPMDAESITFK 99.097 0.0019295 38312200.0 80474.0 51678.0 58540.0 73445.0 70278.0 66823.0 78777.0 78902.0 75523.0 57298.0 True False 76001.57724294631 55641.53642903986 54773.6001335328 63441.66430030811 61449.04934670858 76027.26169120181 82440.28659366416 79131.5917570708 90629.71028893084 55643.65786191731 1.3658623491566326 0.9999618746689386 0.9843637574915796 1.1401418730907658 1.1043315933542266 1.3663239372197187 1.4815756145694827 1.4221134051510425 1.628751842911429 1.0 15.763929641374082 -6.80722662494353 4.24038258057308 1.418633679450838 1.1043343094267286 0.3392508541557897 0.17855737079472966 0.20788483428319002 7.895861760459149 0.06125492354503055 0.05538646128693857 1.55873890441909e-07 6.80722662494353 -0.31429937002410946 DDDDIDLFGS(ph)DDEEESEEAKR ddPTM_A459_Selumetinib_30min_R2 1 DDDDIDLFGSDDEEESEEAKR 21 1 P24534;C9JZW3 P24534 EEF1B2 Elongation factor 1-beta 1 DDDDIDLFGS(1)DDEEESEEAKR 62.19300000000001 0.0080536 4275700.0 47659.0 60537.0 52169.0 30519.0 29035.0 51126.0 46187.0 40339.0 27189.0 35365.0 True False 45010.30357409317 65179.99324286522 48812.50333731247 26362.259551788502 25387.36372380664 58168.14242438061 48334.78701780426 40456.37981151907 32627.559724133567 34343.92056069506 1.3105755790037918 1.8978611695678254 1.4212851223857066 0.7675961020582728 0.7392098312986792 1.693695462682592 1.4073753441277481 1.1779779114041924 0.9500243184662561 1.0 15.06776712042174 -5.52967897973086 24.756424969204748 1.1313375110735984 1.6180571129413173 0.3174082826376847 0.3006076890709989 174.12693993113334 633911.38483273 0.08666503418338192 0.15057634129848613 2.9533914975751133e-06 5.52967897973086 0.4867196018677189 DDDVPLDWR ddPTM_A459_Selumetinib_30min_R2 1 DDDVPLDWR 9 0 O95340;O95340-2 O95340 PAPSS2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 140.35 0.031865 2299800.0 20859.0 20964.0 27404.0 23834.0 30680.0 20674.0 20131.0 27337.0 22422.0 22284.0 False True 19699.740285192926 22571.871390115568 25640.85647521921 20587.76808405671 26825.704117320023 23521.65584011355 21067.131388819733 27416.546144116008 26907.026523024848 21640.603019214734 0.9103138331081387 1.0430333835925902 1.1848494449277889 0.9513490943749022 1.2396005829182037 1.0869223847056677 0.9735002009932064 1.2669030580974479 1.2433584451936965 1.0 14.40145308022571 -4.868338346526049 3.020869134627823 1.1201208784612722 0.8953314113728543 0.2501393132407673 0.11007689410514922 0.44415979581853876 6.613615294111253 0.028168965415988064 0.21886300339819484 1.3541340338373848e-05 4.868338346526049 -0.22478946708841785 DDEVS(ph)EDEEADQLR ddPTM_A459_Selumetinib_30min_R2 2 DDEVSEDEEADQLR 14 0 Q2T9J0-2;Q2T9J0 Q2T9J0-2 TYSND1 Peroxisomal leader peptide-processing protease;Peroxisomal leader peptide-processing protease, 15 kDa form;Peroxisomal leader peptide-processing protease, 45 kDa form 1 DDEVS(1)EDEEADQLR;DDEVS(1)EDEEADQLR 190.82 0.00010366 4196000.0 16175.7 11597.2 15439.6 16934.3 15511.9 14058.6 14301.9 15236.8 9992.6 15426.9 True False 15276.7193504576 12486.667949124609 14446.232945365447 14627.819126703089 13563.156443854514 15995.044538735614 14966.966688677223 15281.136565411962 11991.39921657203 14981.48531310014 1.0197065932507574 0.8334732964164769 0.9642724098079477 0.9763931159690957 0.9053278870817029 1.0676541213673383 0.9990308955274133 1.020001438178483 0.8004145761226016 1.0 13.870893043907895 -5.489289055857052 24.9754656149326 0.9707364067906425 0.9196606687413487 0.035689013863007046 0.08014628604466632 1808.1397552509623 1344431.648098021 0.020297359976085717 0.04220901599976065 3.2412381660289865e-06 5.489289055857052 -0.051075738049293884 DDGDEEGLLTHS(ph)EEELEHSQDTDADDGALQ ddPTM_A459_Selumetinib_30min_R2 1 DDGDEEGLLTHSEEELEHSQDTDADDGALQ 30 0 Q9UKM9-2;Q9UKM9 Q9UKM9-2 RALY RNA-binding protein Raly 1 DDGDEEGLLT(0.003)HS(0.987)EEELEHS(0.005)QDT(0.005)DADDGALQ 108.94 3.8523000000000006e-11 9190600.0 55626.0 34117.0 43694.0 57228.0 42726.0 40931.0 49148.0 46435.0 42683.0 33974.0 True False 52534.5296085211 36733.66419655471 40882.77561043017 49433.44767619356 37358.37790471367 46568.87371537619 51433.47938491446 46570.118162271945 51220.792662664775 32993.0823449471 1.5922892277619154 1.1133747314815672 1.2391317423148063 1.498297344860363 1.1323094191117646 1.4114738728710574 1.5589170738026397 1.411511591289808 1.552470670280046 1.0 15.00987594605612 -6.964383757493404 24.997517304618533 1.4250432184177793 1.3060396871184679 0.013081329779802031 0.2014163046571183 482.36763033051733 338551.9862687965 0.06703509628538809 0.0591192239411657 1.0854660447102638e-07 6.964383757493404 -0.1190035312993114 DDGLFSGDPNWFPK ddPTM_A459_Selumetinib_30min_R1 2 DDGLFSGDPNWFPK 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 ; 199.82 0.0010719000000000002 24184000.0 6853.5 6878.6 7122.0 7735.700000000001 8050.7 6724.200000000001 6227.700000000001 6958.7 5985.9 7751.9 False True 7013.173215410433 6073.250314225619 6154.871518345693 6384.805212073347 7322.515606466524 6656.560653085109 5757.939575049963 6774.132670956804 10157.63510716169 8746.931874900276 0.801786651103921 0.6943292117837445 0.703660621389699 0.7299479752888942 0.8371524679961004 0.7610166339795577 0.6582810587072978 0.7744581491934892 1.161279778148209 1.0 13.094561342168769 -8.20915103397787 6.613629699051155 1.079785960692593 0.7411455225556357 0.8268600782944939 0.061440998234397255 0.07582216517463215 7.7688192143683406 0.042602078968458267 0.015532511970073501 6.178015108168718e-09 8.20915103397787 -0.3386404381369573 DDGLFSGDPNWFPK ddPTM_A459_Selumetinib_30min_R2 1 DDGLFSGDPNWFPK 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 188.06 0.0012605 2281400.0 49838.0 42495.0 58291.0 57497.0 55285.0 35626.0 47120.0 47411.0 38829.0 48271.0 False True 47068.203477321294 45754.22985703879 54540.62052244208 49665.80941214269 48339.60404582915 40533.15811937146 49311.173366508694 47548.95816068641 46595.88497290747 46877.29080687998 1.0040726046056674 0.9760425372176933 1.1634763780853432 1.0594854898238584 1.0311944912724043 0.8646651165562362 1.0519202905657574 1.01432820332074 0.9939969689133313 1.0 15.516601573618045 -6.536208430495449 24.998680852155402 0.9853799980696696 1.0524643959485407 0.19516461147175246 0.06378143168125867 403.56363307190554 756844.8016800103 0.021784562954139438 0.021796354334981814 2.909320515813034e-07 6.536208430495449 0.0670843978788711 DDGSSMSFYVRPS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 DDGSSMSFYVRPSPAK 16 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 DDGSSMSFYVRPS(1)PAK 58.32 0.044435 10534000.0 3354.8 3578.8 3783.2 4141.4 3234.3 3529.0 3631.4 3583.8 2359.3 3003.2 True False 3432.960312695547 3159.7924322610193 3269.4622196300825 3418.182233706133 2941.758136062044 3493.501464075628 3357.4805743430857 3488.745982176984 4003.559783545763 3388.689973645238 1.013064145553182 0.9324524984095869 0.9648159746266487 1.0087031449587494 0.8681107327435958 1.0309297962473811 0.9907901284729863 1.0295264569228548 1.1814476433909666 1.0 11.726511937434381 -7.881378972524593 2.740268443244087 1.0940009152922765 0.9688821616491975 0.3752081841167485 0.06032181678060866 0.257325196894577 3.783741526391579 0.03922447665032065 0.015799871163470005 1.3140776459207782e-08 7.881378972524593 -0.125118753643079 DDGSSMSFYVRPS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 3 DDGSSMSFYVRPSPAK 16 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 DDGSSMSFYVRPS(1)PAK;DDGSSMS(0.001)FYVRPS(0.999)PAK;DDGSSMSFYVRPS(1)PAK 144.41 0.001848 18977800.0 82858.0 82001.0 81579.8 91668.0 82510.0 77345.9 85812.0 79913.8 66556.90000000001 83691.0 True False 78253.0840668543 88290.21302522741 76331.0444853704 79182.66026387962 72144.35615124111 87999.59564882645 89802.42803325212 80146.33592755815 79870.13975516502 81274.62337466802 0.9628230906234443 1.0863195590365053 0.9391743857549704 0.9742605622280812 0.8876615252790865 1.0827438134429361 1.104925797309103 0.9861175924260075 0.9827192848002694 1.0 16.310517345054343 -6.789032943422134 24.99946960432579 1.035035148419376 0.9750260899608278 0.2080321060796434 0.05913699193198902 390.8264198930642 354081.69602604344 0.02195674601652559 0.019368180159352755 1.6254254543730063e-07 6.789032943422134 -0.0600090584585482 DDGSWEVIEGYR ddPTM_A459_Selumetinib_30min_R1 2 DDGSWEVIEGYR 12 0 P49448;P00367 P49448 GLUD2;GLUD1 Glutamate dehydrogenase 2, mitochondrial;Glutamate dehydrogenase 1, mitochondrial 0 ; 173.64 3.7408e-07 2012700.0 1171.33 1639.3 1256.8400000000001 1469.9099999999999 1370.6999999999998 1355.4 1502.83 1190.92 651.06 1178.53 False True 1198.6197099885753 1447.3699939101066 1086.1680313279433 1213.2178121280201 1246.7204270167406 1341.765906604735 1389.470323164626 1159.3329329466533 1104.8012684589933 1329.8058053543298 0.901349434001907 1.0884070351343154 0.816786952617139 0.9123270535014363 0.9375206680531442 1.0089938705352683 1.0448670907963127 0.8718061902562881 0.8307989512533497 1.0 10.376999865645878 DDGSWEVIEGYR ddPTM_A459_Selumetinib_30min_R2 1 DDGSWEVIEGYR 12 0 P49448;P00367 P49448 GLUD2;GLUD1 Glutamate dehydrogenase 2, mitochondrial;Glutamate dehydrogenase 1, mitochondrial 0 118.23 0.047459 0.0 11347.0 11815.0 12761.0 15120.0 11572.0 10180.0 14849.0 11920.0 10996.0 12639.0 False True 10716.379165639974 12721.172508787227 11939.971153126267 13060.629916545171 10118.221905007418 11582.202595160867 15539.507922735293 11954.68522653777 13195.507253910506 12274.079229934261 0.8730902713667239 1.0364258100731978 0.9727793775362664 1.0640822559375904 0.8243569000541322 0.943631076367339 1.2660426604414643 0.9739781699781156 1.075071050684523 1.0 13.583327180852544 DDGVFVQEVTQNS(ph)PAAR ddPTM_A459_Selumetinib_30min_R1 3 DDGVFVQEVTQNSPAAR 17 0 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2;E9PQE3 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 DDGVFVQEVTQNS(1)PAAR;DDGVFVQEVTQNS(1)PAAR;DDGVFVQEVTQNS(1)PAAR 258.89 3.9852e-40 106012000.0 20490.800000000003 21934.5 25233.800000000003 26187.800000000003 23235.5 18760.8 23077.4 20837.6 13177.2 17431.4 True False 20968.1957718439 19366.39854292761 21807.188559341717 21614.592335888716 21133.85312756071 18572.083385443486 21336.65313827868 20284.919157936012 22360.745975390684 19668.889986214563 1.06605892790798 0.9846208177737046 1.1087147558721329 1.0989228345391044 1.0744812311407965 0.9442364769166027 1.0847919304664886 1.0313199764782461 1.1368585614675142 1.0 14.263627920970135 DDGVFVQEVTQNS(ph)PAAR ddPTM_A459_Selumetinib_30min_R2 4 DDGVFVQEVTQNSPAAR 17 0 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2;E9PQE3 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 DDGVFVQEVTQNS(1)PAAR;DDGVFVQEVTQNS(1)PAAR;DDGVFVQEVTQNS(1)PAAR;DDGVFVQEVTQNS(1)PAAR 227.36 3.1848999999999997e-16 93329200.0 148193.0 159367.0 161319.0 172372.0 165072.0 149531.0 160438.0 143070.0 138032.0 164010.0 True False 139957.02632358207 171589.93645432833 150939.91117084687 148894.63624171438 144334.17959759623 170127.53794273076 167898.68490186587 143486.31001348636 165642.2569363196 159274.60515084426 0.8787152615511614 1.0773213739366712 0.9476709173310846 0.9348297307075455 0.9061970642520294 1.068139756376153 1.0541459810423262 0.9008737449237104 1.0399790775148665 1.0 17.281156735377238 -6.7548469289556134 24.99342340086028 1.009027212782751 0.9552236257741719 0.190732423038255 0.06473379204099958 330.37497639356565 1252522.4036735077 0.021884087101621437 0.021394670208930783 1.758543319346268e-07 6.7548469289556134 -0.053803587008579234 DDGYSTKDS(ph)YSSR ddPTM_A459_Selumetinib_30min_R2 1 DDGYSTKDSYSSR 13 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DDGYS(0.002)T(0.002)KDS(0.993)YS(0.002)SR 131.86 0.0070328000000000005 3341700.0 30186.0 27202.0 31090.0 31327.0 30406.0 24440.0 23801.0 25065.0 23694.0 28335.0 True False 28508.382964132208 29288.30593178418 29089.703248232578 27060.20855791073 26586.12644691112 27806.388155769324 24907.793660786785 25137.935000265887 28433.462065674383 27516.89492682864 1.0360319738088208 1.0643753959037157 1.0571579142772562 0.9834034192399868 0.9661746544298487 1.010520563083534 0.9051818429012493 0.9135454805896978 1.0333092502363739 1.0 14.748030061566022 -5.830648914627711 3.9762042063431764 0.9664607187422282 1.054319789852387 0.473724894479683 0.03819632705982436 0.1818644391549243 5.643822549773469 0.011210976347366659 0.017770356335446397 1.4768999825880375e-06 5.830648914627711 0.08785907111015889 DDHDDFFST(ph)TPLQHQR ddPTM_A459_Selumetinib_30min_R2 1 DDHDDFFSTTPLQHQR 16 0 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 DDHDDFFS(0.139)T(0.481)T(0.38)PLQHQR 83.89399999999998 0.013917 3057500.0 15116.0 11513.0 19095.0 19200.0 20887.0 20536.0 14645.0 18567.0 20553.0 18516.0 True False 14275.91323414239 12396.010079870279 17866.44848906404 16584.926878152597 18262.98832785083 23364.647592752804 15326.021518516976 18621.026896067677 24664.1742988016 17981.394969654444 0.7939269037933121 0.6893797784204113 0.9936074770180853 0.922338167096683 1.0156602621026682 1.299379032170929 0.8523266156147118 1.035571874567723 1.3716496601306558 1.0 14.134217326861023 -5.584788730197429 0.9792255631009401 1.0998355570596126 0.7059022640478907 0.4363423529909052 0.14940616898256875 0.7368815819209112 1.2016133246698486 0.0573445275440206 0.23525197827140396 2.6014247619158143e-06 5.584788730197429 -0.39393329301172186 DDIIENAPTTHTEEYSGEEK ddPTM_A459_Selumetinib_30min_R2 1 DDIIENAPTTHTEEYSGEEK 20 0 G3V5L5;G3V580;G3V2X6;H0YJX6;O14744-3;O14744-5;O14744-2;O14744 G3V5L5 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 157.57 2.0254e-06 2670600.0 17245.0 19253.0 19319.0 20650.0 23890.0 16508.0 17046.0 21202.0 16590.0 18474.0 False True 16286.591937204656 20729.64319184769 18076.036572936806 17837.43437676307 20888.724620690213 18781.827155296232 17838.672776008207 21263.694309819944 19908.46356332986 17940.60761878356 0.9078060388630776 1.1554593708489587 1.0075487384279813 0.99424917794242 1.1643264857328475 1.0468891329874428 0.994318205662743 1.1852270983039148 1.1096872517565115 1.0 14.130941132335106 -6.226287262365803 24.99458539906055 1.0863889993694158 1.0255855801120146 0.13645600987450035 0.08119906911595863 1397.0947722213227 993390.532189054 0.023626128455021676 0.030499620802821027 5.938991963958743e-07 6.226287262365803 -0.06080341925740118 DDISEIQSLAS(ph)DHSGR ddPTM_A459_Selumetinib_30min_R2 1 DDISEIQSLASDHSGR 16 0 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 DDISEIQSLAS(0.994)DHS(0.006)GR 143.23 0.00025952 2134400.0 11966.0 11027.0 15288.0 19208.0 18690.0 10291.0 16593.0 18870.0 18006.0 13194.0 True False 11300.977623693307 11872.735442606574 14304.386724315838 16591.837264351827 16341.995109280031 11708.491837603196 17364.607378405748 18924.908575903333 21607.70312967556 12813.054937871084 0.8819893209301254 0.9266123887063622 1.1163915860562557 1.2949165788177441 1.2754175478463443 0.9137939308288479 1.3552277316069101 1.4770020629481315 1.6863818374656656 1.0 13.645326869145258 -4.724021241042928 0.457676004018911 1.3647065099181894 0.4580584393598673 0.3498938450203163 0.20656549783239228 5.980720411424012 0.9362533477234701 0.15298863566574994 2.9932533350691615 1.8878990110024914e-05 4.724021241042928 -0.9066480705583222 DDISEIQSLASDHS(ph)GR ddPTM_A459_Selumetinib_30min_R2 2 DDISEIQSLASDHSGR 16 0 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 DDISEIQSLAS(0.14)DHS(0.86)GR;DDISEIQSLAS(0.325)DHS(0.675)GR 144.75 0.00025693 4981300.0 31756.0 19701.6 45005.0 46579.0 58564.0 34050.0 36332.0 42012.0 49089.0 34029.0 True False 29991.128649340186 21212.649369371353 42109.427297739036 40234.85984674321 51206.66675119723 38740.078424875006 38021.509990492224 42134.247964539005 58908.1716612598 33046.49435203994 0.9075434244204137 0.6419031665929765 1.2742479383487055 1.2175227852651045 1.549534005201864 1.1722901077549124 1.15054594249708 1.2749990215509224 1.7825845922934769 1.0 15.01220961499868 -5.275032905529126 20.664068124477716 1.3082169591450343 0.7747235704801627 0.4881956177497656 0.2161845675606414 54.72263806863908 83187.88528228355 0.05531917566680829 0.1168363136118491 5.30844221818566e-06 5.275032905529126 -0.5334933886648716 DDKEEEEDGT(ph)GSPQLNNR ddPTM_A459_Selumetinib_30min_R2 1 DDKEEEEDGTGSPQLNNR 18 1 P49407-2;P49407 P49407-2 ARRB1 Beta-arrestin-1 1 DDKEEEEDGT(0.673)GS(0.327)PQLNNR 74.029 0.023138 14231000.0 56032.0 42016.0 46341.0 49931.0 40856.0 38248.0 49062.0 63313.0 33110.0 43427.0 True False 52917.96575386787 45238.49209726651 43359.47051226587 43130.311664220666 35723.30402272578 43516.31481922527 51343.48021450865 63497.23034796857 39732.925170696304 42173.149673103464 1.2547786011727995 1.0726846926995832 1.028129766174875 1.0226960044136244 0.8470627472604645 1.0318488222134954 1.217444763136904 1.5056316836696892 0.9421379593100809 1.0 15.364037151891635 -7.259892724706343 22.867025650519324 1.2084395920260962 1.0337352170422702 0.09134204097440912 0.16974938981642268 72.35669960802545 1069811.1315704556 0.06684714187653185 0.04892980918981921 5.4967663298553645e-08 7.259892724706343 -0.17470437498382596 DDKEEEEDGTGS(ph)PQLNNR ddPTM_A459_Selumetinib_30min_R2 1 DDKEEEEDGTGSPQLNNR 18 1 P49407-2;P49407 P49407-2 ARRB1 Beta-arrestin-1 1 DDKEEEEDGT(0.241)GS(0.759)PQLNNR 102.07 0.0013148 16447000.0 52893.0 34969.0 38831.0 40054.0 33305.0 33337.0 36284.0 38592.0 27748.0 29563.0 True False 49953.41880745528 37651.009856942896 36332.65573599609 34598.576102996056 29120.928149522293 37928.869146844605 37971.27789538201 38704.296330750454 33298.37534389854 28709.439376101447 1.739964969467078 1.311450542927866 1.2655299624638587 1.205128935112432 1.014332873868773 1.321128868103836 1.3226060390085632 1.3481383535120164 1.159840668000541 1.0 14.809237538126059 -4.583625810868545 1.89271107409991 1.2170998383661589 2.1462628473562035 0.6570258875858189 0.11545980631834371 1.0046237323898282 2.4176469570483117 0.03163370472190052 1.9660633775072431 2.6083999855616217e-05 4.583625810868545 0.9291630089900447 DDLQRLQEVLQSES(ph)DQLK ddPTM_A459_Selumetinib_30min_R1 1 DDLQRLQEVLQSESDQLK 18 1 A0A087X0P0;Q02224-3;Q02224 A0A087X0P0 CENPE Kinesin-like protein;Centromere-associated protein E 1 DDLQRLQEVLQS(0.354)ES(0.646)DQLK 52.72 0.044071 4217900.0 183.09 236.55 0.0 195.08 165.72 212.72 159.01 274.64 0.0 214.57 True False 187.35564076887667 208.85461603088848 0.0 161.01294010513172 150.73065526024237 210.58022993430654 147.01574768031458 267.35565504355355 0.0 242.11214958879145 0.773838244330512 0.862635833788646 0.0 0.6650345320488856 0.6225654330699496 0.8697631667471484 0.6072216860244698 1.1042636872938274 0.0 1.0 7.9195316677555025 -6.259126119532634 3.3240328374870356 0.7136916774108338 0.5504654280945298 0.03158298928746717 0.3528323883154547 0.9635958859416388 22.43808990666392 0.10926017890861546 0.13580370678824355 5.506477645472236e-07 6.259126119532634 -0.16322624931630403 DDNEDNS(ph)NDGTQPSKR ddPTM_A459_Selumetinib_30min_R1 1 DDNEDNSNDGTQPSKR 16 1 S5FZ81;Q8WUB8-2;Q8WUB8 S5FZ81 PHF10 PHD finger protein 10 1 DDNEDNS(1)NDGTQPSKR 71.89399999999998 0.019895 1919400.0 662.12 515.79 563.62 421.95 453.23 561.12 600.81 565.21 380.42 532.89 True False 677.5461077387546 455.40106701573427 487.08349974305014 348.2643534824706 412.23542652425584 555.4756422561967 555.4904179850939 550.2187947391741 645.5449552225144 601.2916222881627 1.1268178079056086 0.757371382097002 0.8100620093283464 0.5791937565289552 0.6855831866666128 0.92380406056945 0.9238286338852082 0.9150614682528997 1.0735971220852032 1.0 9.23192104758108 -6.912759183330554 6.092037300007844 0.9646951324457684 0.7795770519696303 0.29204023467084683 0.13724864401879475 0.28718926653551424 16.112632688885512 0.05086772371971846 0.04477668671560534 1.2224773370121605e-07 6.912759183330554 -0.1851180804761381 DDNHS(ph)LTFFPESTEQK ddPTM_A459_Selumetinib_30min_R2 1 DDNHSLTFFPESTEQK 16 0 E9PG22;Q8IW35;Q8IW35-2 E9PG22 CEP97 Centrosomal protein of 97 kDa 1 DDNHS(0.997)LT(0.003)FFPESTEQK 98.804 0.0045574 4606000.0 44226.0 35920.0 40373.0 45457.0 46772.0 28694.0 43739.0 38213.0 29443.0 33039.0 True False 41768.09597070531 38674.94849899596 37775.44513479875 39265.678182301155 40896.083213014754 32646.33804180218 45772.95016718429 38324.193503497285 35332.42270615557 32085.07822436883 1.3017919320197313 1.2053873837721263 1.1773524399921222 1.2237987362137273 1.2746137917143647 1.017492861120939 1.4266117678472552 1.1944553550874564 1.101210427447871 1.0 14.969614880110992 -8.437703024569194 2.6671332979693245 1.004119984391117 1.2267379008641461 0.367635135623507 0.09768244981578625 0.2689925601410843 3.9579975811474557 0.08978199224353967 0.02438713553568545 3.6500345505825046e-09 8.437703024569194 0.2226179164730291 DDNMFQIGK ddPTM_A459_Selumetinib_30min_R2 1 DDNMFQIGK 9 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 0 139.97 0.036523 0.0 17306.0 15782.0 19407.0 17175.0 17694.0 12903.0 17889.0 14561.0 13723.0 16363.0 False True 16344.201801407005 16992.42865287177 18158.374748743943 14835.735371472438 15471.121533633006 14680.271128227967 18720.873946381023 14603.370099296679 16467.983452656754 15890.557673820264 1.0285480306543378 1.069341240356016 1.1427147568684712 0.9336195542032079 0.973604693504352 0.9238361188804439 1.1781130864414981 0.9189967022589629 1.0363376660963763 1.0 13.955882136025497 -5.762220199665585 24.999999991801715 0.9953364233938833 1.079115324069732 0.21115094554567726 0.07551750826615561 33.32625114672166 1067093.049454042 0.020767242120562537 0.03295440210518742 1.7289395153886814e-06 5.762220199665585 0.0837789006758487 DDPDGKQEAKPQQAAGMLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 DDPDGKQEAKPQQAAGMLSPK 21 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 DDPDGKQEAKPQQAAGMLS(1)PK;DDPDGKQEAKPQQAAGMLS(1)PK 71.506 0.0060369 70305000.0 5813.6 5638.5 6350.3 6760.1 4602.1 5598.0 5752.9 4967.4 3720.8500000000004 5928.700000000001 True False 5949.045568703596 4978.341798732464 5487.9641397010255 5579.575437793221 4185.840867566747 5541.689202577326 5318.954121313639 4835.648415610789 6314.010689868291 6689.706395428379 0.8892835076841432 0.7441794160255777 0.8203594919279862 0.834053859464774 0.625713689083167 0.8283904965342594 0.795095301185193 0.7228491251746685 0.943839731768074 1.0 12.707727178465353 -8.403253114223922 4.547885381461687 0.9971615295399795 0.7813345117308433 0.5506822687017587 0.06912911418449362 0.15331710445867883 4.640856684535178 0.06448848791079405 0.01686794075573109 3.951362608005421e-09 8.403253114223922 -0.21582701780913616 DDPDGKQEAKPQQAAGMLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DDPDGKQEAKPQQAAGMLSPK 21 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 DDPDGKQEAKPQQAAGMLS(1)PK;DDPDGKQEAKPQQAAGMLS(1)PK 63.90600000000001 0.012916 21624500.0 113920.0 112524.0 101410.0 95973.0 82407.0 72695.0 76140.0 77302.0 43300.0 95178.0 True False 107588.7824578923 121154.22897831324 94885.3910068595 82901.31183734052 72054.2959320727 82708.0763904931 79680.66086854781 77526.936021965 51961.209903085175 92429.96383785747 1.1640032949339538 1.3107678933083264 1.0265652724186864 0.8969094911988463 0.7795556001565879 0.8948188764368802 0.8620652606586026 0.8387641063883172 0.5621684543146267 1.0 16.496072998210416 -5.5886358698894725 2.1707366660952654 0.8223234035458024 1.239922870759656 0.6781057912036408 0.11161880353476522 0.17147699545020323 1.6138593463013629 0.03183858521743618 0.07286617245338804 2.578482154975141e-06 5.5886358698894725 0.41759946721385355 DDPVTNLNNAFEVAEK ddPTM_A459_Selumetinib_30min_R2 1 DDPVTNLNNAFEVAEK 16 0 O43707;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 185.12 1.074e-12 0.0 8342.1 6676.1 8816.7 9999.4 8488.3 4636.4 6472.8 6196.9 5030.9 7123.1 False True 7878.479478072194 7188.135402955093 8249.443120897144 8637.464470072871 7421.923867635192 5275.022014951262 6773.798025609879 6214.93195304798 6037.220575090791 6917.437594963576 1.1389303293185224 1.039132670772282 1.1925576498013324 1.248650869848339 1.072929645659387 0.7625687897483717 0.9792351477867647 0.8984442385968072 0.8727538907595421 1.0 12.756022008413446 -6.5697139849458015 7.479156941689618 0.9018533596514731 1.1507726722103773 0.706818940920048 0.07736589727904482 0.1219914006060758 16.222967412349835 0.02552817765773207 0.025597542290847642 2.6933079625833395e-07 6.5697139849458015 0.2489193125589042 DDS(ph)LDLSPQGR ddPTM_A459_Selumetinib_30min_R2 1 DDSLDLSPQGR 11 0 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 DDS(0.98)LDLS(0.02)PQGR 103.11 0.013616 3864000.0 26467.0 23371.0 28178.0 28688.0 33175.0 25095.0 24593.0 32260.0 21755.0 25025.0 True False 24996.07009579564 25163.480550390694 26365.058157886688 24780.644910439674 29007.259911737034 28551.608460271324 25736.62323010501 32353.87125906949 26106.607885487723 24302.46322724145 1.0285405994474133 1.0354292202851314 1.084871846584391 1.0196762640365695 1.193593408227929 1.1748442202462368 1.059012948171277 1.3313000808413094 1.0742371109206719 1.0 14.568814928179851 -6.25647534255011 24.93610621575945 1.15320602828093 1.0447039155230915 0.2202205947135234 0.0865935792541545 539.2593095839039 2708885.844100885 0.02454252822303511 0.03064049597485367 5.540189979599042e-07 6.25647534255011 -0.1085021127578385 DDSFDSLDS(ph)FGSR ddPTM_A459_Selumetinib_30min_R1 2 DDSFDSLDSFGSR 13 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 DDS(0.001)FDS(0.017)LDS(0.8)FGS(0.182)R;DDSFDS(0.002)LDS(0.998)FGSR 141.59 0.00082077 8893300.0 2221.06 2676.95 1927.95 2061.14 2380.76 1920.72 2420.91 2266.2799999999997 1066.52 2032.0 True False 2272.8063765695633 2363.5314495197085 1666.144979471298 1701.200591389641 2165.420678357316 1901.3993006742264 2238.2988096141776 2206.1708924850873 1809.8065444611648 2292.826993356127 0.9912681520042389 1.030837239952452 0.7266771475995567 0.7419664005697646 0.9444326521939974 0.8292816275209025 0.9762179249023348 0.9622055649544684 0.7893341057591351 1.0 11.162911784263034 -7.259973440554607 24.927347469645596 0.9287898593487232 0.874422870552388 0.059006323912219605 0.10597910944183861 466.64456045648694 7935107.166664703 0.04481168224988579 0.03279100726968359 5.495744822679192e-08 7.259973440554607 -0.05436698879633517 DDSFDSLDS(ph)FGSR ddPTM_A459_Selumetinib_30min_R2 2 DDSFDSLDSFGSR 13 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 DDSFDS(0.003)LDS(0.997)FGSR;DDS(0.001)FDS(0.229)LDS(0.77)FGSR 201.3 3.6772e-22 1610400.0 23271.0 17845.9 23238.0 26958.0 23513.0 18562.800000000003 19133.9 19075.3 16698.6 21645.4 True False 21977.69098119394 19214.62314638731 21742.89237962137 23286.273894856124 20559.08673111298 21119.657203679 20023.66426310357 19130.805964914078 20038.78659786739 21020.4410604968 1.0455390026280693 0.914092291930871 1.0343689895490469 1.107791878764021 0.9780521099411739 1.0047199838907592 0.9525805955010882 0.9101048788584238 0.9533000064173626 1.0 14.359505320453522 -7.174635754488083 2.4332611244440345 0.9453449769296981 1.0157435840725504 0.24858456580752009 0.05075272468355653 0.424242522860833 4.912232020102566 0.023797703841155173 0.01680185976426907 6.689046969451643e-08 7.174635754488083 0.07039860714285229 DDSHSAEDS(ph)EDEKEDHK ddPTM_A459_Selumetinib_30min_R1 3 DDSHSAEDSEDEKEDHK 17 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 DDSHSAEDS(1)EDEKEDHK;DDS(0.182)HS(0.142)AEDS(0.676)EDEKEDHK;DDS(0.006)HS(0.003)AEDS(0.991)EDEKEDHK 87.49600000000002 0.0058273000000000005 78685000.0 13523.8 16841.4 10290.400000000001 10412.5 8120.6900000000005 12901.599999999999 12984.8 12516.400000000001 8725.3 15217.4 True False 13838.878227266014 14869.601058645561 8893.020201121113 8594.152341832498 7386.175023324265 12771.821617715548 12005.346081877537 12184.424413002964 14806.196829301845 17170.701520028306 0.8059588136876076 0.8659868113892326 0.5179182802023603 0.500512593024116 0.43016151755412313 0.743814782571242 0.6991762140803753 0.7096055102227925 0.8622942290407618 1.0 14.067661362325202 -8.370086207970427 1.1189974535648284 1.0003236120461525 0.6364433973574818 0.4387399188511004 0.12998931424335453 0.500277464115872 1.3329659704889534 0.13755778397635005 0.044836644605544373 4.264948506641444e-09 8.370086207970427 -0.3638802146886707 DDSHSAEDS(ph)EDEKEDHK ddPTM_A459_Selumetinib_30min_R2 2 DDSHSAEDSEDEKEDHK 17 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 DDS(0.001)HS(0.001)AEDS(0.999)EDEKEDHK;DDSHSAEDS(1)EDEKEDHK 89.13600000000002 0.004151600000000001 87740000.0 134978.0 85331.0 77808.0 86709.0 89691.0 69062.0 113819.0 116989.0 79329.0 84405.0 True False 127476.46311974552 91875.61331758993 72801.91799094494 74899.08461863207 78423.21473228645 78574.66361758354 119111.80902806981 117329.41862142851 95197.01663745611 81968.00833947324 1.5551977619341133 1.1208716080679186 0.888174782647315 0.9137599672842485 0.9567539375544432 0.9586015960295626 1.4531499720569552 1.4314050200598363 1.1613923354486606 1.0 16.32277332323521 -7.2518917689790054 24.731636049621184 1.2974372538089174 1.0481654198785726 0.15293861184071156 0.21715859355264536 914.9192902226437 2369964.2104712995 0.08678137719042583 0.06632481195780204 5.598971167062568e-08 7.2518917689790054 -0.2492718339303448 DDSLDLS(ph)PQGR ddPTM_A459_Selumetinib_30min_R1 4 DDSLDLSPQGR 11 0 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 DDSLDLS(1)PQGR;DDSLDLS(1)PQGR;DDS(0.027)LDLS(0.973)PQGR;DDS(0.147)LDLS(0.853)PQGR 138.2 0.00127 52632000.0 8257.1 10974.6 10928.8 11873.400000000001 9416.1 9247.4 9026.0 8067.799999999999 5104.360000000001 6842.400000000001 True False 8449.474364480262 9689.688730046879 9444.728987601296 9799.933581321875 8564.415417547481 9154.379551967402 8345.161553125708 7853.815736092266 8661.726112295866 7720.688690620061 1.0943938686124737 1.2550290677849731 1.2233013615839463 1.26930821511142 1.1092812779710277 1.1856946859014206 1.080883051697749 1.01724289772672 1.1218851658685682 1.0 12.914513827262615 -7.155754388598444 1.198540325655116 1.0441658770341462 1.207983987498577 0.5450321429589882 0.06044725269304524 0.3568403125590801 1.0185476696970486 0.037024159685207295 0.02319654541638629 6.98627394916521e-08 7.155754388598444 0.16381811046443073 DDSLDLS(ph)PQGR ddPTM_A459_Selumetinib_30min_R2 1 DDSLDLSPQGR 11 0 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 DDS(0.017)LDLS(0.983)PQGR 122.52 0.0041278 26211000.0 109700.0 113310.0 119630.0 116840.0 130690.0 101440.0 110130.0 106150.0 87752.0 118630.0 True False 103603.31316389402 122000.51265092536 111933.13604329566 100926.19043975789 114271.5538165762 115412.43921936331 115251.26321845493 106458.87892592156 105304.85199573956 115204.84366224363 0.8992965041264858 1.0589877020154221 0.9716009543093524 0.8760585686453624 0.9918988662629182 1.0018019690016533 1.000402930595066 0.9240833591861519 0.9140661854849718 1.0 16.813841849034716 -8.434631135537511 0.007426389788818213 0.9555758290319918 0.9741243813695547 0.0 0.05472173110346535 749997.6052543048 4028.2538760170232 5070.783481794848 4986.266163819814 3.6759438122579287e-09 8.434631135537511 0.018548552337562918 DDTIYEDEDVKEAIR ddPTM_A459_Selumetinib_30min_R1 2 DDTIYEDEDVKEAIR 15 1 E5RHG9;B7Z2R2;P14927;P14927-2 E5RHG9 UQCRB Cytochrome b-c1 complex subunit 7 0 ; 204.35 1.886e-05 9122500.0 2194.1000000000004 2614.3 2322.9 3064.3 1881.6399999999999 2695.9 1748.46 2529.7 1069.2 1182.15 False True 2245.218261024591 2308.2165406449017 2007.4629387763578 2529.1775290350392 1711.4459942305236 2668.781693681352 1616.5722545067783 2462.6041383763377 1814.3543087217083 1333.890467616116 1.6832103651187862 1.7304393401731615 1.5049683519847232 1.8960908638586345 1.283048372996594 2.000750255342111 1.21192278808009 1.8461816754545226 1.36019737210077 1.0 10.381424489179452 -10.79933640529301 0.29902287443564096 0.578545567700384 1.6911450606179013 0.38438058127212116 0.24650695036237613 18.0253022789697 1.171118078879397 6.196747241285045 0.2471213397359571 1.5873167338537823e-11 10.79933640529301 1.1125994929175174 DDVAPES(ph)GDTTVK ddPTM_A459_Selumetinib_30min_R2 1 DDVAPESGDTTVK 13 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 DDVAPES(0.578)GDT(0.101)T(0.321)VK 92.063 0.023057 0.0 29219.0 21728.0 24054.0 25319.0 22688.0 21544.0 23664.0 25727.0 21961.0 19497.0 True False 27595.1249529245 23394.467733468384 22506.391828014996 21870.508522288823 19837.73060670655 24511.490443039875 24764.42288932643 25801.86131066587 26353.81364160862 18934.07095071036 1.4574322143801408 1.2355751594239526 1.188671569183626 1.1550874917086067 1.0477266435912604 1.2945705393651894 1.3079291270109732 1.3627212751992908 1.3918725513500776 1.0 14.20869701293519 -6.935855686684782 24.999992298218032 1.2966372665805133 1.2087554815353145 0.01989265436498988 0.1390436443699906 166.3364522318841 64827.44439756446 0.048931376977891516 0.043153426106862625 1.1591624745394298e-07 6.935855686684782 -0.08788178504519872 DDWLHNR ddPTM_A459_Selumetinib_30min_R2 2 DDWLHNR 7 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 ; 107.59 0.023364 4344000.0 49423.0 36862.0 45655.0 46287.0 48437.0 46942.0 50529.0 60662.0 48216.0 36966.0 False True 46676.267515944644 39689.19686998857 42717.60700540553 39982.63075047131 42351.91102772592 53407.83440295107 52878.698621314026 60838.51637686529 57860.547267601694 35898.695530797486 1.3002218277235473 1.105588832216458 1.1899487258181318 1.113762774922287 1.1797618381813406 1.4877374682635054 1.4729977744163265 1.694727774291184 1.611772974256492 1.0 15.13164380060497 -6.762478269814183 6.170365914699132 1.4995101632676449 1.1697619397407004 0.35495463005543215 0.18044639903256984 0.14084302159319897 21.054214780133993 0.05937230942058541 0.05559808359164392 1.7279124354837234e-07 6.762478269814183 -0.32974822352694444 DDYVHEFCR ddPTM_A459_Selumetinib_30min_R1 3 DDYVHEFCR 9 0 Q13564-3;Q13564-2;Q13564;Q13564-4 Q13564-3 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 ;; 104.42 0.020176 8395900.0 8302.2 9863.9 8616.4 9113.3 7667.700000000001 8258.2 8666.8 7341.1 4590.6 7625.2 False True 8495.62510673094 8709.030002397301 7446.340206497311 7521.833232828052 6974.157888842383 8175.130005845666 8013.056298319288 7146.390180746542 7789.912915841642 8603.968695737769 0.9874077192934814 1.0122107960145854 0.8654541258600902 0.8742283356463414 0.8105745308321773 0.9501580369411919 0.9313209498645425 0.830592303791937 0.9053860132825223 1.0 13.070786560400974 -5.257811762248972 24.85080040228417 0.8892863221611902 0.9998092687252481 0.3703178821208487 0.05360209256268408 268.64439767004086 1840312.042462244 0.013468451967222211 0.03286416051924622 5.523167799694931e-06 5.257811762248972 0.11052294656405792 DDYVHEFCR ddPTM_A459_Selumetinib_30min_R2 1 DDYVHEFCR 9 0 Q13564-3;Q13564-2;Q13564;Q13564-4 Q13564-3 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 125.71 0.006994499999999999 5129600.0 47725.0 41268.0 53004.0 52766.0 59572.0 37632.0 36483.0 48132.0 41363.0 45163.0 False True 45072.63555831213 44433.122902465606 49593.78034639174 45579.17977357288 52088.032779562884 42815.46641071647 38179.53178969302 48272.05615131846 49636.75577878319 43859.0268424338 1.0276706713133033 1.0130895758835299 1.130754235030348 1.0392200432836514 1.1876239973744125 0.9762064845746263 0.8705056755330047 1.100618495817035 1.1317340887910312 1.0 15.420586180955153 DEALQNIS(ph)ADDLPDSASQAAHPQDSAFSYR ddPTM_A459_Selumetinib_30min_R2 1 DEALQNISADDLPDSASQAAHPQDSAFSYR 30 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 DEALQNIS(0.98)ADDLPDS(0.013)AS(0.007)QAAHPQDSAFSYR 63.563 0.00054541 4345700.0 4488.1 4314.5 5062.9 5973.3 5808.3 6791.8 3969.5 4285.5 5737.8 4271.1 True False 4238.669369287805 4645.408276695937 4737.158526068728 5159.726235482754 5078.6094271391785 7727.308800178154 4154.089615415031 4297.970095497286 6885.520327527073 4147.782245349491 1.021912221655372 1.1199740010229289 1.1420943159154626 1.2439723038179882 1.224415633880813 1.8629977040964583 1.001520660847761 1.0362091935554685 1.6600486525653908 1.0 12.018124440674205 -5.707982776012021 1.7353564586370362 1.3087148696238817 1.0683415641349114 0.1087080496481635 0.26562605805874945 0.8654129124897294 5.269820525482338 0.08363964992917548 0.18767612503910497 1.958922362234641e-06 5.707982776012021 -0.2403733054889703 DEALQNISADDLPDS(ph)ASQAAHPQDSAFSYR ddPTM_A459_Selumetinib_30min_R1 2 DEALQNISADDLPDSASQAAHPQDSAFSYR 30 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 DEALQNIS(0.24)ADDLPDS(0.745)AS(0.015)QAAHPQDSAFSYR;DEALQNISADDLPDS(0.994)AS(0.006)QAAHPQDSAFSYR 148.3 8.7356e-20 17295800.0 1284.37 1353.38 1240.28 1440.29 1089.27 1250.04 1253.98 814.59 546.01 724.26 True False 1314.293322051025 1194.9256404307073 1071.8567883703734 1188.770389091758 990.7457208262384 1237.465732545509 1159.3912790149097 792.9844270387713 926.5390910074267 817.2258258898174 1.60823762589733 1.4621731259283688 1.3115796814219705 1.4546412404397437 1.212327963017429 1.5142273938762556 1.418691434222032 0.9703369642966784 1.133761393307151 1.0 9.674590986472436 -7.755037632660603 24.995079893379685 1.0390368586849847 1.4192533105993441 0.7321979484235115 0.10837800405439783 75.98415163871664 296677.11216894956 0.05241128502905316 0.029314738413352585 1.7577712922523175e-08 7.755037632660603 0.3802164519143594 DEALQNISADDLPDS(ph)ASQAAHPQDSAFSYR ddPTM_A459_Selumetinib_30min_R2 1 DEALQNISADDLPDSASQAAHPQDSAFSYR 30 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 DEALQNISADDLPDS(0.5)AS(0.5)QAAHPQDSAFSYR 80.722 0.00013781 0.0 8033.4 5248.1 8634.8 8957.7 8742.1 6624.5 4870.6 5933.4 5474.9 6555.9 True False 7586.935788248184 5650.6123946987955 8079.246368859394 7737.645807105602 7643.839242634402 7536.96474377635 5097.092550910807 5950.665211672752 6570.032981487324 6366.61413272616 1.1916751400480252 0.8875380660582337 1.2690020473095471 1.2153470660852461 1.2006129291459569 1.1838262201307699 0.8005970590726301 0.9346671696474715 1.0319508681569902 1.0 12.636310612780186 -7.2427603901476845 24.914011991766 0.9363593671331488 1.1552956723999488 0.47452540422313727 0.11137446178396959 713.1180410464062 951157.2912694663 0.04396541457778285 0.03399528311102397 5.7179402104484195e-08 7.2427603901476845 0.21893630526679997 DEAQNEGPATESEAPLKEDGLLPKPLS(ph)SGGEEEEKPR ddPTM_A459_Selumetinib_30min_R1 1 DEAQNEGPATESEAPLKEDGLLPKPLSSGGEEEEKPR 37 3 Q8N163-2;Q8N163;G3V119;H0YB24 Q8N163-2 CCAR2 Cell cycle and apoptosis regulator protein 2 1 DEAQNEGPAT(0.004)ES(0.005)EAPLKEDGLLPKPLS(0.496)S(0.496)GGEEEEKPR 45.894 0.00917 28074000.0 2899.1 3813.8 2886.7 2267.9 2514.7 2705.5 2998.2 3175.7 2491.7 2816.6 True False 2966.6433893333883 3367.2785230124796 2494.701995508077 1871.853838755528 2287.2458290063437 2678.2851263974553 2772.0433601353316 3091.4701198726075 4228.232913432362 3178.138046007317 0.9334532818863458 1.0595129834724388 0.7849570910370497 0.5889781411814792 0.719681082412327 0.8427214575408941 0.8722224522681887 0.972729968025275 1.330411974629068 1.0 11.633966075794326 -7.9569260995015485 3.0739296767624547 1.1664161879535604 0.8223198600259125 0.4752029848207613 0.13982579981214177 0.23208394890291578 4.351305701900318 0.10626984902696997 0.04111714031434003 1.1042665083189596e-08 7.9569260995015485 -0.3440963279276479 DEAQNEGPATESEAPLKEDGLLPKPLS(ph)SGGEEEEKPR ddPTM_A459_Selumetinib_30min_R2 2 DEAQNEGPATESEAPLKEDGLLPKPLSSGGEEEEKPR 37 3 Q8N163-2;Q8N163;G3V119;H0YB24 Q8N163-2 CCAR2 Cell cycle and apoptosis regulator protein 2 1 DEAQNEGPAT(0.001)ES(0.001)EAPLKEDGLLPKPLS(0.499)S(0.499)GGEEEEKPR;DEAQNEGPATESEAPLKEDGLLPKPLS(0.5)S(0.5)GGEEEEKPR 53.408 0.00094212 32971100.0 34625.0 29547.8 36598.0 37946.0 35180.7 27786.7 36233.0 36201.8 25237.1 33539.5 True False 32700.68111485715 31814.021248848345 34243.32452488952 32777.689339498866 30760.985946551526 31614.065702451535 37917.906294327455 36307.141244469385 30285.225183490773 32571.127488913666 1.0039775603711472 0.9767552953049286 1.051339857256861 1.006341869824909 0.9444249652402035 0.9706162524834951 1.1641570070681062 1.1147032369950152 0.9298181401242265 1.0 14.991306040778824 DEAS(ph)SVTR ddPTM_A459_Selumetinib_30min_R2 2 DEASSVTR 8 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 DEAS(0.5)S(0.5)VTR;DEAS(0.758)S(0.242)VTR 91.867 0.026264 21146800.0 60094.0 36003.0 45239.0 54957.0 62923.0 47677.0 84385.0 139599.0 78320.0 73270.0 True False 56754.21605534226 38764.31433210889 42328.37199249897 47471.76179388709 55018.05020124276 54244.07398128535 88309.06970570529 140005.20997814156 93986.18844364063 71154.50472167764 0.7976194378323281 0.5447907266551334 0.5948797220649247 0.6671645313191891 0.7732194949068514 0.7623420919513416 1.241088952148962 1.9676225774569707 1.3208747473019395 1.0 16.118667474795934 -7.328796508370521 3.1913012982086406 1.4994973735432933 0.6739414278015382 0.6716656513445587 0.23746516462906692 0.13295602804640677 2.670120148265159 0.10355235280010748 0.0675685891808849 4.690330993108903e-08 7.328796508370521 -0.8255559457417551 DEDDDEEEEEEGGSWGR ddPTM_A459_Selumetinib_30min_R1 1 DEDDDEEEEEEGGSWGR 17 0 Q5VYD6;O00165-4;O00165-6;O00165;O00165-2;O00165-3 Q5VYD6 HAX1 HCLS1-associated protein X-1 0 188.09 9.2187e-07 3097500.0 493.71 589.65 604.26 495.51 693.07 588.11 433.85 385.83 383.18 380.38 False True 505.2124824075705 520.613503879152 522.2048109625907 408.9784803746867 630.3819408714468 582.1941473611554 401.124345205361 375.59653504753237 650.22847364009 429.2054782149625 1.1770876842222895 1.2129703144618504 1.2166778791696844 0.952873393125366 1.4687183012974672 1.3564462172814353 0.9345741505295108 0.8750972532075167 1.5149584677817898 1.0 8.745524679995723 -14.326236211431512 0.26068451835244133 5.7294175590769915e-11 1.194276654075069 0.05684936585278211 0.20953082529132294 602.7466152536609 6.509587120287506 323.74277638301504 0.28239087564362464 4.718063574400304e-15 14.326236211431512 1.194276654017775 DEDDDEEEEEEGGSWGR ddPTM_A459_Selumetinib_30min_R2 2 DEDDDEEEEEEGGSWGR 17 0 Q5VYD6;O00165-4;O00165-6;O00165;O00165-2;O00165-3 Q5VYD6 HAX1 HCLS1-associated protein X-1 0 ; 312.05 4.326599999999997e-102 13575500.0 18300.3 12411.9 17471.2 20732.0 19570.2 17588.0 17610.7 17158.800000000003 12686.7 10222.2 False True 17283.24258790528 13363.852819451226 16347.122013204273 17908.26583530518 17111.616516192204 20010.587352032355 18429.632444940027 17208.729267207742 15224.394496015497 9927.058525534772 1.741023541207966 1.346204697501903 1.6467236464009514 1.8039851169649934 1.723734827610518 2.0157620004516272 1.8565048647124018 1.733517458665401 1.5336259433602317 1.0 13.277150582548945 -8.687057412008292 2.4365512562519283 1.0005097376637127 1.7326462107765395 0.6550416031633645 0.16065441482014184 0.445170184760798 4.957706912627398 0.17253513500474363 0.046736532980946974 2.055618833363453e-09 8.687057412008292 0.7321364731128268 DEDDEDGDGDGDGATGK ddPTM_A459_Selumetinib_30min_R2 1 DEDDEDGDGDGDGATGK 17 0 P50579-3;P50579;G3V1U3;F8VQZ7;F8VY03 P50579-3 METAP2 Methionine aminopeptidase 2 0 312.91 4.223099999999997e-197 0.0 31452.0 19511.0 19325.0 26421.0 21866.0 25677.0 38367.0 36863.0 24423.0 17607.0 False True 29704.023752331737 21007.430962246945 18081.650539469098 22822.414221232782 19118.99759547979 29213.773677401343 40151.1415227682 36970.26522700184 29308.282435636225 17098.640161520092 1.7372155605203994 1.2286024364395627 1.0574905588200656 1.3347502494726948 1.1181589538626844 1.708543685429789 2.348206707871833 2.162175756537772 1.7140709529400775 1.0 14.061593973067604 -6.923187696918633 5.262990674932195 1.9195849245604648 1.2842996268274949 0.2809307010611136 0.3772656150529509 0.21102324796030042 10.357171018810286 0.13136904453185838 0.11511526487688599 1.1934721884763433e-07 6.923187696918633 -0.6352852977329699 DEDEGIPS(ph)ENEEEK ddPTM_A459_Selumetinib_30min_R2 2 DEDEGIPSENEEEK 14 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 DEDEGIPS(1)ENEEEK;DEDEGIPS(1)ENEEEK 202.32 1.5563e-29 0.0 57703.0 34078.0 44310.0 52997.0 43682.0 43919.0 81051.0 83931.0 47645.0 33302.0 True False 54496.098263410844 36691.67302195945 41459.14284108024 45778.71717507565 38194.27663796526 49968.44359301282 84820.03209950964 84175.22531447493 57175.33131252874 32340.484731012795 1.6850736380939895 1.1345430758733834 1.2819579912271117 1.4155235320630897 1.1810050763196815 1.54507404600203 2.6227198758765593 2.6027818078359037 1.7679181925712033 1.0 14.981053682163976 -7.063225436996831 6.940282597121224 2.1298036740054758 1.3319428340155077 0.30325104902181876 0.4550359680356713 0.25194051275263796 23.470007822637857 0.16711814560680227 0.1300472396328057 8.645190409361774e-08 7.063225436996831 -0.797860839989968 DEDEGIPS(ph)ENEEEKK ddPTM_A459_Selumetinib_30min_R2 1 DEDEGIPSENEEEKK 15 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 DEDEGIPS(1)ENEEEKK 62.589 0.038738 14765000.0 114560.0 72276.0 60449.0 75524.0 56387.0 71577.0 117830.0 103890.0 62394.0 51808.0 True False 108193.2138200155 77819.33679603093 56559.77715189482 65237.50091383316 49303.16095382414 81436.08203868651 123309.32847571548 104192.30270008456 74874.54343402082 50312.16842665038 2.150438297600894 1.5467299309407223 1.1241768924023374 1.2966545262095446 0.9799450609190645 1.6186160244198455 2.450884792522647 2.0709165587244667 1.4881994908086635 1.0 15.6186197498717 -7.001831283254519 24.99882039036327 1.8693157184884128 1.3929978048769778 0.082124602360507 0.4614470533322802 123.38111896926837 1684298.1543153739 0.16550626746502653 0.1438381283863095 9.957921922129052e-08 7.001831283254519 -0.47631791361143505 DEDGES(ph)GGQRSEAEEGEVR ddPTM_A459_Selumetinib_30min_R2 1 DEDGESGGQRSEAEEGEVR 19 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 DEDGES(0.601)GGQRS(0.399)EAEEGEVR 140.95 0.00052642 1715400.0 2941.9 2609.1 4128.8 2850.4 3367.0 2713.3 4022.1 4188.3 3549.0 2571.1 True False 2778.400975358792 2809.2095804212245 3863.157503097545 2462.1706027857376 2944.0073586380877 3087.0324461149326 4209.13561963995 4200.487259589607 4258.89916734525 2496.8656624799405 1.1127554906575248 1.1250944024081204 1.5472027835332456 0.9861045549163654 1.1790811988315129 1.236363050084491 1.6857677539044478 1.6823040673392067 1.7056981604349593 1.0 11.285902487471033 -7.196189657726051 6.407527788984428 1.5746876660221332 1.197779351569212 0.29818773454615366 0.23497857697372618 0.25034157472505497 19.862791399431764 0.08712984177183071 0.06700732223218533 6.365174910725987e-08 7.196189657726051 -0.3769083144529213 DEDMLYS(ph)PELAQR ddPTM_A459_Selumetinib_30min_R1 3 DEDMLYSPELAQR 13 0 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 1 DEDMLYS(1)PELAQR;DEDMLYS(1)PELAQR;DEDMLYS(1)PELAQR 261.41 8.6495e-30 76443500.0 9689.8 8099.4 7843.6 7638.299999999999 7947.5 6313.5 7039.9 7510.7 4660.24 7108.5 True False 9915.553486931347 7151.118482691091 6778.4822018107725 6304.414293648901 7228.650028245087 6249.991922199343 6508.87467514399 7311.491837808098 7908.086909537283 8020.945217653555 1.2362076061943283 0.8915555821216639 0.8450976808683089 0.7859939349508726 0.901221717901192 0.7792089027666634 0.8114847438202669 0.9115499033350835 0.9859295500650124 1.0 12.969556543844625 -4.7615956268899815 4.893104544355105 0.8661632120586589 1.2613268145624972 0.6825564523123391 0.07278062721730474 0.10074829909410056 6.107753401437046 0.018225338496756754 0.13799555238360386 1.731427747341252e-05 4.7615956268899815 0.3951636025038383 DEDMLYS(ph)PELAQR ddPTM_A459_Selumetinib_30min_R2 4 DEDMLYSPELAQR 13 0 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 1 DEDMLYS(1)PELAQR;DEDMLYS(1)PELAQR;DEDMLYS(1)PELAQR;DEDMLYS(1)PELAQR 213.52 1.2657000000000002e-21 53947700.0 113955.0 95715.0 113154.0 125988.0 123765.0 103462.0 100057.0 104132.0 103181.0 105835.0 True False 107621.83729800853 103056.03272776713 105873.79483276006 108828.21705857753 108216.53422686152 117712.95136547496 104709.84875918414 104435.0068800194 123820.0831180192 102779.2685576464 1.0471162016262652 1.0026928015153709 1.0301084675785372 1.058853780395785 1.0529023580875698 1.1452985900503136 1.0187837511263755 1.0161096527111821 1.2047184695478887 1.0 16.649189764597644 -5.9089363675321565 2.100920430624956 1.0745329996820598 1.0229635424155232 0.10845871802639562 0.05955659360152037 0.7066400952331578 6.336007135018357 0.018232753942934783 0.03090718097466504 1.2332855199646358e-06 5.9089363675321565 -0.05156945726653661 DEEDT(ph)SFESLSK ddPTM_A459_Selumetinib_30min_R1 2 DEEDTSFESLSK 12 0 H7C3L4;E7EQA9;Q92844 H7C3L4 TANK TRAF family member-associated NF-kappa-B activator 1 DEEDT(0.639)S(0.361)FESLSK;DEEDT(0.656)S(0.344)FESLSK 239.87 6.1051e-13 11152400.0 4480.8 4706.9 4919.8 3797.3999999999996 4410.200000000001 4227.5 4811.1 4673.9 2331.05 4031.3 True False 4585.193921880949 4155.813959821555 4251.718182526984 3134.2553760263863 4011.2981886840485 4184.975188262886 4448.194853561168 4549.932989033153 3955.6215968441293 4548.7566231872825 1.0080103865104428 0.9136153687883184 0.9346989814433805 0.6890356279009351 0.8818449789633632 0.9200261818647274 0.9778924708537932 1.0002586126151207 0.8696050205632793 1.0 12.151256531357221 -6.983435570473315 3.5618221079189736 0.9612963510366213 0.8794195727598834 0.1566627464093684 0.0829216019659796 0.4569129878373123 12.424609908053652 0.033637852358156764 0.02784881548839244 1.0388777131409644e-07 6.983435570473315 -0.0818767782767379 DEEDTS(ph)FESLSK ddPTM_A459_Selumetinib_30min_R2 2 DEEDTSFESLSK 12 0 H7C3L4;E7EQA9;Q92844 H7C3L4 TANK TRAF family member-associated NF-kappa-B activator 1 DEEDT(0.062)S(0.938)FESLSK;DEEDT(0.047)S(0.783)FES(0.169)LS(0.001)K 129.76 0.0022633 11387500.0 57550.0 46705.0 58871.0 59226.0 58938.0 40144.0 54199.0 52425.0 38958.0 42661.0 True False 54351.60139090336 50287.12331975517 55083.30395389832 51159.31662945133 51533.681527594825 45673.47160905088 56719.36089328105 52577.54807057404 46750.68857746862 41429.26608341051 1.3119132084424572 1.2138067620727562 1.3295746983062122 1.2348593510310097 1.2438955936086546 1.102444622530735 1.3690650657215755 1.2690919497516184 1.1284459754450964 1.0 15.338362642849855 -8.50806085811893 3.0254437499136015 1.0012266247849626 1.2568843000637384 0.5903558048702371 0.0690868780623626 0.16090617429387635 3.549051693348569 0.06588646019263909 0.01758311813017983 3.104124573576901e-09 8.50806085811893 0.2556576752787758 DEEPSGWEEPS(ph)PQSISR ddPTM_A459_Selumetinib_30min_R1 2 DEEPSGWEEPSPQSISR 17 0 Q9UPQ9;Q9UPQ9-1;H0Y720 Q9UPQ9 TNRC6B Trinucleotide repeat-containing gene 6B protein 1 DEEPS(0.003)GWEEPS(0.996)PQSISR;DEEPSGWEEPS(0.987)PQS(0.013)ISR 235.02 4.1678999999999995e-17 6718600.0 1789.6399999999999 2016.29 1696.38 1669.3200000000002 1638.3600000000001 1794.98 1933.85 1849.48 928.97 1811.24 True False 1831.33512996675 1780.221829452209 1466.0209135483394 1377.804599017319 1490.1706272759518 1776.92413091144 1787.9781375484315 1800.4257824422925 1576.3942407156808 2043.7302969716307 0.8960747573593224 0.8710649502481396 0.7173260169018718 0.6741616548225221 0.7291425045095552 0.8694513818895085 0.8748601222958974 0.8809507717873228 0.7713318352482998 1.0 10.996989106723161 -6.780743906680807 23.324399736063445 0.8715996779451527 0.7736590352239021 0.2782968969283638 0.08134577879859498 172.07362026490958 207902.7128183688 0.030615110937457946 0.02705342109081939 1.65674662029754e-07 6.780743906680807 -0.09794064272125058 DEEPSGWEEPS(ph)PQSISR ddPTM_A459_Selumetinib_30min_R2 4 DEEPSGWEEPSPQSISR 17 0 Q9UPQ9;Q9UPQ9-1;H0Y720 Q9UPQ9 TNRC6B Trinucleotide repeat-containing gene 6B protein 1 DEEPSGWEEPS(1)PQSISR;DEEPSGWEEPS(0.996)PQS(0.004)ISR;DEEPSGWEEPS(0.924)PQS(0.076)ISR;DEEPSGWEEPS(0.995)PQS(0.005)ISR 329.08 1.1829999999999993e-135 23121200.0 50049.3 42733.2 45997.7 54584.6 58267.0 43938.7 50200.9 51921.899999999994 43867.4 39646.9 True False 47267.76026922224 46010.69903110506 43038.25806050909 47150.083316312885 50946.978546410886 49990.85708919403 52535.3413211962 52072.98413286672 52642.10575756582 38502.190981982785 1.2276641682895744 1.195015085054144 1.11781321952948 1.2246077979919872 1.3232228412728948 1.2983899309155524 1.3644766695427872 1.3524680753164002 1.3672496139817043 1.0 15.232652924809011 -6.098750943473199 4.209749766202693 1.3061417909454092 1.1800766220643706 0.14843813555641716 0.10485512270473804 0.3301839594970029 10.142366038337462 0.029648010256361476 0.039590023045382595 7.966160579243603e-07 6.098750943473199 -0.12606516888103858 DEFEGLFK ddPTM_A459_Selumetinib_30min_R2 2 DEFEGLFK 8 0 P22314;P22314-2;Q5JRR6 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 ; 133.55 0.042008 4904700.0 29027.0 25934.0 28494.0 32015.0 32232.0 22510.1 24931.0 27189.0 21498.9 27579.0 False True 27413.795544287594 27923.054409046792 26660.727061921498 27654.50177104453 28182.728002264008 25610.661948657256 26090.340899839284 27268.115488618758 25799.28072945585 26782.72261115254 1.0235626878677475 1.042577142527676 0.9954449907501098 1.032550057458646 1.0522727062307136 0.9562381808783238 0.9741481954106882 1.0181233582751625 0.9632807352719557 1.0 14.70901500555727 -6.759299915534882 24.99999903341203 0.9829776856890017 1.0283219406601327 0.5442382917375305 0.021457363775404997 47.0817409200189 550162.0528015647 0.007300574888459518 0.00696315969481878 1.7406044298300468e-07 6.759299915534882 0.04534425497113104 DEGLCS(ph)ANVTR ddPTM_A459_Selumetinib_30min_R2 2 DEGLCSANVTR 11 0 A0A3B3IS67;P48307-2;P48307 A0A3B3IS67 TFPI2 Tissue factor pathway inhibitor 2 1 DEGLCS(0.996)ANVT(0.004)R;DEGLCS(1)ANVTR 111.31 0.008318700000000002 13080700.0 65337.0 49721.0 61022.0 68355.0 54276.0 54120.0 56010.0 50964.0 52404.0 62596.0 True False 61705.831104734214 53534.44082178667 57095.91095573005 59044.93108104794 47457.363646403566 61574.53874755467 58614.57598170946 51112.29680245562 62886.264290098756 60788.690836060196 1.0150873502301183 0.8806644802758236 0.9392521893539518 0.9713144051791645 0.7806939579335633 1.012927534722105 0.9642348794743077 0.8408191737555156 1.0345059817079374 1.0 15.891515328344505 DEGNYLDDALVR ddPTM_A459_Selumetinib_30min_R1 2 DEGNYLDDALVR 12 0 P09525;Q6P452;P09525-2 P09525 ANXA4 Annexin A4;Annexin 0 ; 197.07 0.0020465999999999995 10170900.0 3080.9 2717.9 2235.3 2151.67 2650.1000000000004 2127.3 2717.8999999999996 2932.3 1884.67 2979.7 False True 3152.678975612169 2399.6870044825705 1931.758537624002 1775.921226348209 2410.3989229131566 2105.9012934338575 2512.8866148061575 2854.5258785472333 3198.1473391494037 3362.173519735851 0.9376907399650981 0.7137308620142548 0.5745564666084725 0.5282062974809623 0.7169168720068111 0.6263511627440654 0.7473994426687359 0.8490120637115418 0.9512142429224372 1.0 11.715178467773482 -7.940091746778885 1.5549702784100257 0.9906292547337072 0.6731662436860553 0.5572148232658827 0.10385520110925711 0.31398061530297416 1.3735817928297334 0.09519056977335219 0.03282694109925825 1.147911094191368e-08 7.940091746778885 -0.31746301104765196 DEGNYLDDALVR ddPTM_A459_Selumetinib_30min_R2 4 DEGNYLDDALVR 12 0 P09525;Q6P452;P09525-2 P09525 ANXA4 Annexin A4;Annexin 0 ;;; 156.01 0.0059747 27333900.0 48817.0 40680.5 46901.7 54816.8 55164.8 45553.4 40823.1 54278.6 39882.0 47441.6 False True 46103.94656993445 43800.56354157586 43884.095684709835 47350.65727574556 48234.504644430795 51827.96735740684 42721.455039438035 54436.54173969402 47859.51439618576 46071.83773992 1.0006969296557195 0.9507014629812315 0.9525145476601089 1.0277570767427298 1.0469411903366923 1.1249381379136805 0.9272791608749101 1.1815578542144027 1.0388019394050954 1.0 15.491597525687581 -5.941571137323361 3.180686726874338 1.0588809884989103 0.9663124041743963 0.25066672309114457 0.0651918468299638 0.3166270078520059 6.531285108363631 0.018611951851128877 0.028556110071849883 1.1440074763415275e-06 5.941571137323361 -0.09256858432451398 DEILPT(ph)TPISEQK ddPTM_A459_Selumetinib_30min_R1 1 DEILPTTPISEQK 13 0 P23396;P23396-2;H0YEU2;E9PL09;E9PSF4;E9PPU1 P23396 RPS3 40S ribosomal protein S3 1 DEILPT(0.494)T(0.494)PIS(0.012)EQK 244.23 6.7683e-18 1840800000.0 7882.8 9111.1 7790.0 8581.1 7211.2 7203.4 8045.7 7172.9 4103.0 5919.4 True False 8066.453902741284 8044.368176364528 6732.160787407042 7082.571972196769 6558.948233240764 7130.940336163894 7438.806371369771 6982.651391137143 6962.491328736602 6679.21264983871 1.2076953266244748 1.2043886904182912 1.0079273022651272 1.0603902500944928 0.9819942225374648 1.0676318766907493 1.1137250393651419 1.0454303159977638 1.0424119868237363 1.0 12.705462331504947 -5.253140980286304 24.69486709586949 1.0438465956157361 1.2060420412660244 0.7751330404788386 0.03573639611572059 240.69088748318524 716257.4660726275 0.009435783554190898 0.024029842570891757 5.5828893406361415e-06 5.253140980286304 0.16219544565028832 DEILPT(ph)TPISEQK ddPTM_A459_Selumetinib_30min_R2 3 DEILPTTPISEQK 13 0 P23396;P23396-2;H0YEU2;E9PL09;E9PSF4;E9PPU1 P23396 RPS3 40S ribosomal protein S3 1 DEILPT(0.941)T(0.058)PIS(0.001)EQK;DEILPT(0.608)T(0.389)PIS(0.003)EQK;DEILPT(0.917)T(0.051)PIS(0.032)EQK 191.19 1.5241e-06 276584000.0 811100.0 667582.0 712304.0 780003.0 816525.0 542832.0 668967.0 683291.0 464690.3 655734.0 True False 766022.3090905604 718783.3927855433 666475.1361379568 673765.2458197742 713945.829673883 617602.1806617253 700075.2910329623 685279.2636850846 557641.3445318161 636801.2556184593 1.202922108478888 1.128740539444231 1.046598338583171 1.0580463525710477 1.1211438786823704 0.9698507583216244 1.0993622968802903 1.076127375125138 0.8756913395062901 1.0 19.280483654967774 -1.5228787452803376 0.2792757803675081 0.9930031736986352 2.4522218115266377 0.4775911522827644 0.0632312439714918 49.7334427957423 0.7005935767190432 0.07061699868467484 35.38091762796739 0.029999999999999995 1.5228787452803376 1.4592186378280023 DEILPTT(ph)PISEQK ddPTM_A459_Selumetinib_30min_R1 5 DEILPTTPISEQK 13 0 P23396;P23396-2;H0YEU2;E9PL09;E9PSF4;E9PPU1 P23396 RPS3 40S ribosomal protein S3 1 DEILPT(0.228)T(0.772)PISEQK;DEILPT(0.226)T(0.774)PISEQK;DEILPT(0.002)T(0.997)PIS(0.001)EQK;DEILPT(0.225)T(0.775)PISEQK;DEILPT(0.341)T(0.659)PISEQK 244.23 6.7683e-18 2284707500.0 32864.799999999996 37109.899999999994 35347.8 33573.7 33128.5 30332.4 33777.7 33084.5 18340.8 28254.6 True False 33630.48589623125 32765.055656075554 30547.762911566988 27710.683551402806 30132.033024311717 30027.28359561566 31229.8208944177 32206.991586398355 31122.998040968127 31881.35313311023 1.0548638182268515 1.0277184760407034 0.9581702126639584 0.8691815380515956 0.9451303054329345 0.9418447037127469 0.979563846114929 1.0102140725310036 0.9762132087375388 1.0 14.960425242158879 -10.36795453655071 15.089123586655472 0.9999999446166554 0.9711918735024897 0.023264801367404386 0.04891872931012188 0.0 0.0 0.05254265204250309 0.012743464954195047 4.285933846878276e-11 10.36795453655071 -0.028808071114165723 DEILPTT(ph)PISEQK ddPTM_A459_Selumetinib_30min_R2 6 DEILPTTPISEQK 13 0 P23396;P23396-2;H0YEU2;E9PL09;E9PSF4;E9PPU1 P23396 RPS3 40S ribosomal protein S3 1 DEILPT(0.126)T(0.874)PISEQK;DEILPT(0.149)T(0.835)PIS(0.017)EQK;DEILPT(0.23)T(0.768)PIS(0.002)EQK;DEILPT(0.002)T(0.998)PISEQK;DEILPT(0.211)T(0.788)PIS(0.001)EQK;DEILPT(0.329)T(0.663)PIS(0.008)EQK 263.72 1.1143e-29 3104228600.0 1748722.0 1768154.0 1849553.0 1862378.0 1764329.0 1427425.0 1570842.0 1702309.0 1228509.0 1602159.0 True False 1651535.0319288138 1903765.726288801 1730554.7736210416 1608718.903618757 1542678.217718617 1624039.8368759812 1643889.2655643723 1707262.4373575726 1474245.1274094488 1555900.5067609926 1.0614657073201352 1.2235780617180847 1.1122528504239881 1.03394715576494 0.99150184154776 1.0437941435322482 1.0565516615111534 1.0972825254178231 0.9475188940444975 1.0 20.56931837836823 -5.678075183835078 3.9221578700573954 1.0288657790070566 1.1475305504245228 0.4704914011752539 0.052812478630463185 0.18171909154153548 5.325998008098841 0.01420775178289416 0.02539271447696216 2.0985765525246583e-06 5.678075183835078 0.11866477141746623 DEILPTTPISEQK ddPTM_A459_Selumetinib_30min_R2 1 DEILPTTPISEQK 13 0 P23396;P23396-2;H0YEU2;E9PL09;E9PSF4;E9PPU1 P23396 RPS3 40S ribosomal protein S3 0 173.04 0.0022172 3425400.0 27070.0 24052.0 24365.0 25029.0 23555.0 22347.0 21735.0 19094.0 17617.0 23615.0 False True 25565.55776979588 25896.711060630594 22797.382426606193 21620.007022566726 20595.810315628216 25425.09640413162 22745.72056708544 19149.56037881814 21140.892260107415 22933.173590861414 1.1147849933854528 1.1292249176952165 0.9940788324076816 0.9427394310215326 0.8980793798131538 1.1086601818713484 0.9918261193535519 0.8350157165534648 0.9218476534155656 1.0 14.48514839460706 -5.350318745676002 3.454975613251004 0.955912767581884 1.1243206258932705 0.47713212361018564 0.06797543351275427 0.2152566916789395 4.829111284285582 0.019736364443466457 0.047710058323864935 4.463558739005743e-06 5.350318745676002 0.1684078583113865 DELADEIANSS(ph)GKGALALEEK ddPTM_A459_Selumetinib_30min_R1 1 DELADEIANSSGKGALALEEK 21 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 DELADEIANS(0.355)S(0.645)GKGALALEEK 50.098 0.034605000000000004 6080900.0 1520.7 1622.8 1083.1 1414.0 1326.0 1388.6 1400.6 1255.4 605.38 1298.3 True False 1556.1293512328957 1432.8018215807472 936.0209690424356 1167.0714440673382 1206.0635341243144 1374.631944747923 1294.9516143704705 1222.1027138860952 1027.28564479419 1464.949451512923 1.062240986967712 0.9780554681262379 0.6389442093553209 0.7966632861373122 0.8232799656525727 0.9383476974773943 0.8839565167474634 0.8342285889960037 0.7012430659182562 1.0 10.51663516957597 -5.016602209733827 23.19937075662194 0.8247821670643617 1.0411948383621121 0.38961669857283154 0.09910740724442822 240.6708345253809 336314.02012193855 0.02520706493473306 0.0711996142159902 9.624934667418872e-06 5.016602209733827 0.21641267129775044 DELHIVEAEAMNY(ph)EGSPIK ddPTM_A459_Selumetinib_30min_R1 1 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNY(0.737)EGS(0.263)PIK 85.176 0.01627 42792000.0 1024.4 1613.4 829.4 566.75 839.33 1176.3 1277.7 1414.6 856.04 1404.0 True False 1048.2665268645874 1424.5023779506894 716.7720355680874 467.7777517151089 763.4127496957468 1164.4674899949457 1181.3220603178286 1377.0802127316147 1452.6373573121327 1584.2170761181117 0.6616937430274445 0.8991838299339764 0.45244559370893206 0.2952737719892079 0.48188645432756994 0.7350428849361352 0.7456819384957537 0.8692496965794264 0.9169433780322609 1.0 10.62955431779543 -7.496338813111635 1.3353675114751042 0.9490248775934005 0.5654246438903467 0.5180118989046651 0.15249843656215947 0.43063240099206723 1.4591670469778997 0.12466839833052712 0.05931185830834092 3.1890489605217465e-08 7.496338813111635 -0.38360023370305374 DELHIVEAEAMNY(ph)EGSPIKVTLATLK ddPTM_A459_Selumetinib_30min_R1 2 DELHIVEAEAMNYEGSPIKVTLATLK 26 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNY(0.533)EGS(0.467)PIKVTLATLK;DELHIVEAEAMNY(0.765)EGS(0.235)PIKVTLATLK 151.3 1.0362e-10 84823000.0 7348.14 7617.1 6084.2 5273.48 5706.52 5038.790000000001 6859.0 6518.35 3800.25 6324.639999999999 True False 7519.337365008537 6725.2863909062835 5257.99905811835 4352.565713479648 5190.366273567934 4988.104347455271 6341.620107787416 6345.4621834151885 6448.74669072173 7136.469151210578 1.0536495297163881 0.9423828854869295 0.73677878327638 0.6099046490996617 0.7273017179213166 0.6989597014665334 0.888621526054193 0.889159898118356 0.903632672415856 1.0 12.800994745755037 -7.445151954194306 6.921542727233263 0.9160327337861056 0.7874201865944097 0.20452053403829074 0.12180057292775341 0.48411828169282883 36.770377808445154 0.05797131368217556 0.03867622701124276 3.587963743272827e-08 7.445151954194306 -0.1286125471916959 DELHIVEAEAMNY(ph)EGSPIKVTLATLK ddPTM_A459_Selumetinib_30min_R2 1 DELHIVEAEAMNYEGSPIKVTLATLK 26 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNY(0.545)EGS(0.455)PIKVTLATLK 96.708 2.1369e-06 101170000.0 526020.0 376110.0 422190.0 440480.0 397090.0 334730.0 394530.0 482100.0 329760.0 380080.0 True False 496785.91422489926 404956.42761573894 395026.7550457157 380485.8641296166 347204.00417035894 380836.01912359515 412876.4267463641 483502.83118404885 395721.21426423447 369106.10283356404 1.345916283722104 1.0971274235428732 1.0702254772087574 1.0308305964292979 0.9406617812735513 1.0317792531740402 1.1185846659721495 1.3099291165122462 1.0721069395123808 1.0 18.49367606586734 -4.760724678663158 4.672565477094319 1.0772523466190926 1.366729785429415 0.43993516465516025 0.09207167607599719 0.2100538698936026 10.724864922157868 0.025503181678902514 0.2036710206887441 1.7349034926719726e-05 4.760724678663158 0.2894774388103223 DELHIVEAEAMNYEGS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 12 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNY(0.052)EGS(0.948)PIK;DELHIVEAEAMNY(0.429)EGS(0.571)PIK;DELHIVEAEAMNY(0.064)EGS(0.936)PIK;DELHIVEAEAMNY(0.006)EGS(0.994)PIK;DELHIVEAEAMNY(0.102)EGS(0.898)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK 303.07 1.1957999999999995e-100 889701300.0 106504.59999999999 149430.8 51362.19999999999 46269.90000000001 66842.2 74647.79999999999 109269.3 107405.09999999999 56740.80000000001 125283.3 True False 108985.94995812405 131935.37246750575 44387.49535236947 38189.73055859359 60796.33481194882 73896.91090677954 101027.02872778183 104556.36784706646 96284.993415934 141364.6319176838 0.7709562744207918 0.9332983128646445 0.31399293267509926 0.2701505322832896 0.4300675068948671 0.5227397398085364 0.7146556204143734 0.7396218306425424 0.6811109123249476 1.0 17.109061691193318 -8.43771950831901 0.8050802248110163 0.9826591726107178 0.5408803393506212 0.3158257826687837 0.19412406180039266 0.8746929202572763 1.276004265164709 0.21095081412250394 0.07862564118500082 3.649896015286617e-09 8.43771950831901 -0.4417788332600966 DELHIVEAEAMNYEGS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 18 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNY(0.015)EGS(0.985)PIK;DELHIVEAEAMNY(0.017)EGS(0.983)PIK;DELHIVEAEAMNY(0.065)EGS(0.935)PIK;DELHIVEAEAMNY(0.002)EGS(0.998)PIK;DELHIVEAEAMNY(0.197)EGS(0.803)PIK;DELHIVEAEAMNY(0.144)EGS(0.856)PIK;DELHIVEAEAMNY(0.001)EGS(0.999)PIK;DELHIVEAEAMNY(0.019)EGS(0.981)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNY(0.004)EGS(0.996)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK;DELHIVEAEAMNYEGS(1)PIK 210.33 9.972e-17 341082800.0 1006516.0 669460.0 827921.0 988404.0 958919.0 949908.0 1331008.0 1373105.0 1193160.0 736294.0 True False 950577.8701227887 720805.4293468223 774653.4642322294 853781.6701079974 838451.0223753721 1080749.204593719 1392902.509342317 1377100.5082202295 1431825.3396758677 715035.2790984417 1.3294139434928762 1.0080697420351845 1.083377963125061 1.1940413222470578 1.1726009147863867 1.5114627713983437 1.9480192796900455 1.9259196692456326 2.0024541187411016 1.0 19.44765489915965 -6.923652383465806 2.973496752402623 1.794271148073847 1.1435697675788858 0.4669849509938293 0.27917157312020746 0.19492340641634304 3.4871422839939763 0.10242362446206377 0.08695270868540939 1.1921958796608794e-07 6.923652383465806 -0.6507013804949611 DELHIVEAEAMNYEGS(ph)PIKVTLATLK ddPTM_A459_Selumetinib_30min_R1 9 DELHIVEAEAMNYEGSPIKVTLATLK 26 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNY(0.445)EGS(0.554)PIKVT(0.001)LATLK;DELHIVEAEAMNY(0.192)EGS(0.782)PIKVT(0.023)LAT(0.003)LK;DELHIVEAEAMNY(0.266)EGS(0.733)PIKVTLATLK;DELHIVEAEAMNY(0.439)EGS(0.559)PIKVT(0.003)LATLK;DELHIVEAEAMNY(0.089)EGS(0.911)PIKVT(0.001)LATLK;DELHIVEAEAMNY(0.048)EGS(0.947)PIKVT(0.005)LAT(0.001)LK;DELHIVEAEAMNY(0.128)EGS(0.86)PIKVT(0.012)LAT(0.001)LK;DELHIVEAEAMNY(0.047)EGS(0.921)PIKVT(0.03)LAT(0.002)LK;DELHIVEAEAMNY(0.176)EGS(0.764)PIKVT(0.025)LAT(0.034)LK 127.96 4.0221e-09 985825300.0 32382.880000000005 35366.399999999994 27551.409999999996 25371.14 27301.12 27097.7 31246.62 30970.920000000002 17660.949999999997 29437.98 True False 33137.33809788432 31225.68544660669 23810.079851062168 20940.546674281886 24831.73851640423 26825.121740743052 28889.662296601895 30149.470593873757 29969.34224524755 33216.63148320757 0.9976128408636697 0.9400617718383819 0.7168119941090108 0.6304235480611039 0.7475694375860399 0.8075810382610379 0.8697348589126761 0.9076618924804463 0.9022390563714545 1.0 15.019618155773344 -7.905585238787942 1.1748661868332377 0.9704601427513421 0.7991648086045393 0.2607101944479411 0.10065745373273977 0.7500115817520534 1.866758472121958 0.10209342984571462 0.03714473391921234 1.2428386805008716e-08 7.905585238787942 -0.17129533414680276 DELHIVEAEAMNYEGS(ph)PIKVTLATLK ddPTM_A459_Selumetinib_30min_R2 1 DELHIVEAEAMNYEGSPIKVTLATLK 26 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 DELHIVEAEAMNY(0.476)EGS(0.518)PIKVT(0.004)LAT(0.002)LK 78.419 9.7418e-05 4931900.0 6668.1 7685.1 6684.7 9051.2 6056.7 7202.2 9276.1 8868.8 5719.0 8182.4 True False 6297.513696519243 8274.522458508734 6254.613679751051 7818.410945809098 5295.803198415 8194.237674937876 9707.457030243448 8894.606739691118 6862.959802211177 7946.152851571642 0.7925236040826574 1.0413243506726837 0.787124762961736 0.9839240563139585 0.6664612797333193 1.0312207464417409 1.2216549582636638 1.1193601363874954 0.8636833358741364 1.0 12.956040829923419 -6.974939961697237 24.895206532172352 1.0704522744462144 0.8662063884977576 0.35029142890842724 0.1300292513904473 230.96472882900673 229444.8680338162 0.04468662092349157 0.03940842159380543 1.0594001700310775e-07 6.974939961697237 -0.20424588594845683 DELHIVEAEAMNYEGSPIK ddPTM_A459_Selumetinib_30min_R1 4 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 ;;; 217.35 6.292600000000001e-19 33086300.0 16858.699999999997 18514.4 13254.600000000002 12116.2 14937.8 12520.0 16284.7 15788.100000000002 10724.7 15817.399999999998 False True 17251.47490868021 16346.725440888958 11454.698122306225 10000.333119242354 13586.67862748279 12394.060167250456 15056.331968112807 15369.348301023629 18199.03259890358 17847.717364523236 0.9665927892253491 0.9159000620091693 0.6418018555737148 0.5603144040772685 0.7612558149587063 0.6944339107412539 0.8435998654954611 0.8611380372693496 1.0196840429061629 1.0 14.123451951985215 -7.949027993069361 1.6296348524288506 1.0131887975156273 0.7521181016850528 0.41374115731159367 0.1143908073005653 0.4249499109372214 2.045948650336699 0.10913391600486495 0.03741474331785013 1.1245324882877558e-08 7.949027993069361 -0.2610706958305745 DELHIVEAEAMNYEGSPIK ddPTM_A459_Selumetinib_30min_R2 2 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 ; 195.17 3.8482e-15 8198600.0 70198.0 53576.0 64194.0 70814.0 69960.0 59450.0 71768.0 74334.0 66524.0 59298.0 False True 66296.67618485895 57685.106926007975 60063.827929142564 61169.011039036304 61170.999349664664 67638.6978666319 75105.3542055942 74550.29963334382 79830.65883586237 57585.91266529325 1.1512655286058466 1.0017225438674782 1.0430298861155802 1.0622217866819115 1.0622563144081614 1.1745702158055302 1.304231377596275 1.2945926561354115 1.3862879850470082 1.0 15.813428305563717 -6.947312087647724 2.917040189943128 1.2700195011416875 1.0585696094513661 0.4157720524608587 0.10036712222214556 0.21841636024946934 3.782126085890631 0.037241403458172825 0.03112228766483665 1.1289843255196708e-07 6.947312087647724 -0.21144989169032136 DELHIVEAEAMNYEGSPIKVTLATLK ddPTM_A459_Selumetinib_30min_R1 3 DELHIVEAEAMNYEGSPIKVTLATLK 26 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 ;; 184.88 2.7953e-21 44291300.0 5449.0 5785.740000000001 4349.65 4646.35 4654.24 4652.28 5451.32 5210.28 3354.61 5153.16 False True 5575.951098091701 5108.342871082445 3758.9914209172102 3834.9521952915666 4233.26481377281 4605.482287132264 5040.122543517091 5072.0864490253625 5692.528158979548 5814.618282029069 0.9589539377546066 0.8785345182280543 0.6464726038052963 0.6595363632285286 0.7280383007868868 0.7920523865455077 0.86680196344003 0.8722991266170284 0.9790028997386022 1.0 12.505468769447504 -7.871730594564288 1.2014369681719537 0.9968877732930082 0.768306142142722 0.4562114930723199 0.08944976218471708 0.48201840631821896 1.2539814287260629 0.08824569780412805 0.032467364812091164 1.343598175509976e-08 7.871730594564288 -0.22858163115028618 DELT(ph)ESPK ddPTM_A459_Selumetinib_30min_R1 1 DELTESPK 8 0 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.903)ES(0.097)PK 105.17 0.033371 75644000.0 7227.2 10909.0 5922.4 5867.3 5018.7 6023.9 8008.9 8551.3 6264.6 10555.0 True False 7395.579698316816 9631.76920854349 5118.170609414567 4842.686197861594 4564.759471123451 5963.305035263585 7404.782224997622 8324.49174546293 10630.568651719055 11909.837064406456 0.6209639693912459 0.8087238436979829 0.42974312593332176 0.406612296345713 0.38327639970538435 0.5007041660616349 0.6217366522273787 0.6989593308829867 0.8925872448322066 1.0 13.539866055725387 -8.12986029482908 1.398998372179188 0.9955156540506234 0.5245511349709148 0.6663609581844028 0.11694294486462037 0.279720931163856 1.000749097409721 0.1223193964998471 0.039312685556663764 7.415487465953679e-09 8.12986029482908 -0.4709645190797086 DELT(ph)ESPK ddPTM_A459_Selumetinib_30min_R2 4 DELTESPK 8 0 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.933)ES(0.067)PK;DELT(0.951)ES(0.049)PK;DELT(0.912)ES(0.088)PK;DELT(0.937)ES(0.063)PK 130.98 0.008614299999999998 304538000.0 1297641.0 993780.0 931893.0 868181.0 779762.0 788182.0 1380831.0 1198924.0 764527.0 765124.0 True False 1225523.3080885003 1069999.7304936554 871936.0189483799 749933.2501042378 681801.3263992734 896746.9160961779 1445042.3775647199 1202412.6703474456 917453.7626691909 743032.8820891073 1.6493527239909296 1.4400435785361878 1.1734824123756802 1.0092867599556692 0.9175924011361709 1.2068737975295105 1.9447892716427924 1.6182496082363793 1.2347418058938155 1.0 19.503066531468782 DELT(ph)ESPKYIQK ddPTM_A459_Selumetinib_30min_R1 1 DELTESPKYIQK 12 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.998)ES(0.002)PKYIQK 183.89 0.0010815999999999998 15219000.0 4006.2 3812.0 5748.6 5592.2 3989.4 4647.0 3504.7 4179.1 3068.7 3958.3 True False 4099.536665291787 3365.6892678492773 4967.971694799504 4615.627248595026 3628.5594743857755 4600.255399138411 3240.337657349841 4068.2566923700642 5207.359771019741 4466.386362107069 0.9178643164577872 0.7535598121120617 1.1123022712383097 1.0334142356680383 0.8124150443344004 1.0299725608530177 0.72549425746974 0.9108608979476683 1.1658999801716907 1.0 12.124892340700724 -8.242380225441984 23.780435661534657 1.0829499662392823 0.9118269258731094 0.23483029445416803 0.12344313893861031 549.1114550727978 685139.534261219 0.08373344107093385 0.03150860274530274 5.722947666997359e-09 8.242380225441984 -0.17112304036617287 DELTDLDQS(ph)NVTEETPEGEEHHPVADTENK ddPTM_A459_Selumetinib_30min_R2 1 DELTDLDQSNVTEETPEGEEHHPVADTENK 30 0 Q8NC51-3;Q8NC51-4 Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.001)DLDQS(0.903)NVT(0.075)EET(0.02)PEGEEHHPVADTENK 67.586 0.00020749 6966000.0 23961.0 16444.0 15684.0 23699.0 17969.0 24253.0 32117.0 37098.0 25124.0 20619.0 True False 22629.343543482806 17705.20192420628 14674.908515448036 20471.155316944707 15711.573575101824 27593.630603186313 33610.50413862816 37205.94903809547 30149.502023212746 20023.67589540425 1.1301293359765476 0.8842133690482828 0.7328778488077786 1.022347516204213 0.7846498144083465 1.3780502015376452 1.6785381622333542 1.8580978453928543 1.5056926700522821 1.0 14.28941922431612 -6.902310322997611 4.2346956093209975 1.5769024269486982 0.907096737537707 0.6005604784180902 0.2325650004868663 0.133158913356763 4.349159180932628 0.08202750560323428 0.0717272136803323 1.2522460688797512e-07 6.902310322997611 -0.6698056894109912 DELTDLDQSNVTEET(ph)PEGEEHHPVADTENKENEVEEVKEEGPK ddPTM_A459_Selumetinib_30min_R2 1 DELTDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPK 43 2 Q8NC51-3;Q8NC51-4 Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELTDLDQS(0.002)NVT(0.037)EET(0.878)PEGEEHHPVADT(0.083)ENKENEVEEVKEEGPK 62.822 3.7225e-06 26414000.0 18456.0 14007.0 12816.0 13295.0 11835.0 9697.2 22663.0 14715.0 7572.4 14097.0 True False 17430.28940522176 15081.291860396326 11991.43251300575 11484.198064845763 10348.181493757587 11032.901277582912 23716.87440588257 14757.818213800607 9087.091590534003 13689.982981595322 1.273214833696643 1.1016297011231837 0.8759274959747513 0.8388759927813647 0.7558944015978384 0.8059105181076877 1.7324254119064502 1.0780012096173437 0.6637766900624054 1.0 13.740833032691405 DELTES(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 DELTESPK 8 0 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.033)ES(0.967)PK;DELTES(1)PK;DELT(0.007)ES(0.993)PK 123.11 0.0060721 114940000.0 19537.1 29511.3 14556.4 13916.900000000001 13431.999999999998 16494.0 20310.0 19992.899999999998 15063.800000000001 26383.5 True False 19992.27641742106 26056.103276568843 12579.72083258176 11486.57466756771 12217.077971612205 16328.085335353775 18778.0003483252 19462.62334590832 25562.168383578446 29770.07922205284 0.6715560367945325 0.8752446737618089 0.4225625581561454 0.3858429324923925 0.4103811038084889 0.5484730226467919 0.6307675639107801 0.6537645802262748 0.8586530184522556 1.0 14.861575440329654 -8.298344649254892 1.3695328297747975 1.0003622228048905 0.5514737867358784 0.5416579869701343 0.13652597706193523 0.35206534258562805 1.3150933938829712 0.14481705613532497 0.04495554099233019 5.031011971459926e-09 8.298344649254892 -0.4488884360690121 DELTES(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 DELTESPK 8 0 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.19)ES(0.81)PK 88.056 0.031604 15948000.0 111170.0 81542.0 83020.0 72141.0 60636.0 71077.0 97596.0 80089.0 54725.0 63944.0 True False 104991.61644877022 87796.00920114492 77678.58358534146 62315.27134983366 53018.36358728217 80867.21157723466 102134.40738280531 80322.0457305523 65671.5291442572 62097.77057353556 1.6907469540221285 1.4138351246793595 1.2509077679907246 1.0035025537034463 0.8537885192592921 1.3022562779685063 1.6447354943581873 1.2934771246809211 1.0575505132908054 1.0 15.922253853466371 -4.930666320136955 2.064239337486784 1.1887192348270377 1.7471125230981568 0.37923647322977794 0.20827725534824673 0.6327748585735075 3.8577588391638398 0.06318651770338793 0.599205721525643 1.1730963401278945e-05 4.930666320136955 0.5583932882711191 DELTES(ph)PKYIQK ddPTM_A459_Selumetinib_30min_R1 1 DELTESPKYIQK 12 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.003)ES(0.997)PKYIQK 198.48 0.00059639 15730000.0 5356.2 5389.4 7082.8 7447.8 4867.9 5698.3 5128.7 5385.6 3878.4 4524.9 True False 5480.989038649064 4758.406542535912 6120.994663035512 6147.181542521018 4427.59930449755 5640.980275642435 4741.838029859943 5242.756393105741 6581.361532871562 5105.714991258438 1.0735007825609415 0.9319765303552671 1.198851615006977 1.2039805498437903 0.8671849705825925 1.1048364989625217 0.9287314387854603 1.026840785684656 1.2890185888048193 1.0 12.317897291233164 -11.357510130176815 2.409500429158102 0.9749446471661208 1.0628578686932229 0.023221796536112005 0.1288949197164759 31236179.01877558 17975903.156060327 4520555.477341632 0.03165199632529117 4.390256249879725e-12 11.357510130176815 0.08791322152710201 DELTES(ph)PKYIQK ddPTM_A459_Selumetinib_30min_R2 2 DELTESPKYIQK 12 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 DELT(0.001)ES(0.999)PKYIQK;DELT(0.017)ES(0.983)PKYIQK 155.09 0.0020161 8813900.0 93846.0 74709.0 78600.0 77698.0 69083.0 53391.0 70328.0 64925.0 42470.0 72475.0 True False 88630.41501530354 80438.94007270281 73542.96157320932 67115.39836347407 60404.17593014414 60745.12561475774 73598.39135228834 65113.92100108762 50965.1867109475 70382.45843733568 1.2592685305844318 1.142883352736546 1.0449046993532851 0.9535813305417514 0.8582277071768444 0.8630719495091459 1.045692250403784 0.925144168686025 0.7241177395973436 1.0 16.102928287405256 -5.257023918709894 1.1982511369962294 0.9027974777884558 1.2888577942410653 0.678013475722469 0.08244571025093095 0.4622679397194101 0.9576442497356523 0.02727708016281831 0.18092196077078626 5.533196343724658e-06 5.257023918709894 0.3860603164526095 DEMYRS(ph)LFQDLELK ddPTM_A459_Selumetinib_30min_R1 1 DEMYRSLFQDLELK 14 1 D6REK8;F8W7L6;P42262-4;P42262-2;P42262;P42262-3 D6REK8 GRIA2 Glutamate receptor 2 1 DEMYRS(1)LFQDLELK 99.344 0.0053666 11914000.0 2044.4 2917.0 2864.0 2990.7 2641.0 2421.8 2425.5 2321.2 1360.6 1934.3 True False 2092.0305422900833 2575.47628392349 2475.084530825902 2468.4303873919275 2402.122016306422 2397.4388908184637 2242.5425822187467 2259.634235679786 2308.8388257077795 2182.586246677537 0.9585099079015534 1.1800112310998172 1.1340145364672867 1.1309657939747029 1.1005851521162453 1.098439474943081 1.027470316754941 1.035301234542065 1.0578454020877441 1.0 11.091822948915663 -7.210359783229755 4.488425704900323 1.0328279798113165 1.1078007571487054 0.27415379182950916 0.055278359204106474 0.28041699186616403 12.317874831295308 0.021636841940958506 0.016149294837082204 6.160844066640206e-08 7.210359783229755 0.07497277733738894 DENQSINHQMAQEDAQR ddPTM_A459_Selumetinib_30min_R1 1 DENQSINHQMAQEDAQR 17 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 133.9 0.011897 4644300.0 589.59 896.9 438.69 693.45 935.43 573.25 948.59 907.64 189.77 628.08 False True 603.3262998575676 791.8905310425018 379.11830755168137 572.351975168667 850.8205216635799 567.4836254693552 877.0370925858097 883.5664387697744 322.02582974758604 708.7001860172817 0.8513138725814522 1.1173843984615401 0.5349487908028241 0.8076080498654055 1.2005366140017248 0.8007386433161131 1.2375290847806029 1.2467422137070368 0.4543893681717383 1.0 9.469031617485335 -6.1759889805392305 24.999979154356936 1.005251676330057 0.8275776821959281 0.08478398561273359 0.25812617089682877 206.58479699468376 60436.268080516274 0.07538263586298713 0.09731855488576246 6.668236884805264e-07 6.1759889805392305 -0.17767399413412888 DENQSINHQMAQEDAQR ddPTM_A459_Selumetinib_30min_R2 3 DENQSINHQMAQEDAQR 17 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 ;; 112.03 0.010905 12340200.0 21994.2 20226.899999999998 26700.7 31536.3 38072.0 28737.8 26401.5 34389.8 30602.5 34946.8 False True 20771.850413758584 21778.238190265623 24982.806031524076 27241.001536848093 33289.05499200157 32696.171094225338 27629.22206357976 34489.86862446214 36723.85510529249 33937.795081309174 0.6120565689076963 0.6417104628656245 0.7361352136068219 0.8026744657861035 0.9808844361351898 0.9634147125908116 0.8141136451965972 1.0162672189466138 1.08209313590669 1.0 15.050605216421975 -5.596166840617723 0.6287898649651885 1.001415911841831 0.5106724490474647 0.8316768468267999 0.06464479480170637 0.6423040653165154 0.37270309710346594 0.03970154236317167 0.2000261782431275 2.534154910565643e-06 5.596166840617723 -0.4907434627943664 DEPAES(ph)PSETPGPR ddPTM_A459_Selumetinib_30min_R2 2 DEPAESPSETPGPR 14 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 DEPAES(0.991)PS(0.009)ETPGPR;DEPAES(0.648)PS(0.352)ETPGPR 230.57 2.4638e-13 23104000.0 27184.0 21033.0 23781.0 28013.0 34533.0 31687.0 37005.0 37351.0 42431.0 26540.0 True False 25673.22210617404 22646.163468245588 22250.95635079506 24197.581074879607 30194.655811062996 36051.596624053294 38725.80582401643 37459.6852262091 50918.385621196474 25773.721240798735 0.9961007130601843 0.8786532319748088 0.8633195083825426 0.9388470081136687 1.1715287648593833 1.3987734362155322 1.5025306381724608 1.4534061603379167 1.9755930913303577 1.0 14.65361322982669 -6.620427841221721 1.6202922451869384 1.523322171729855 0.9022903000712623 0.5729906345844847 0.2226373808305612 0.2482479464849987 1.342017144440519 0.08696462090855535 0.08843717550028596 2.396470894446717e-07 6.620427841221721 -0.6210318716585927 DEPDS(ph)PVLYR ddPTM_A459_Selumetinib_30min_R2 2 DEPDSPVLYR 10 0 Q6ZTQ3-4;Q6ZTQ3-3;Q6ZTQ3-2;Q6ZTQ3 Q6ZTQ3-4 RASSF6 Ras association domain-containing protein 6 1 DEPDS(1)PVLYR;DEPDS(1)PVLYR 130.1 0.0028366 14473500.0 151374.0 105250.0 121629.0 144125.0 140189.0 98490.0 123568.0 132557.0 94150.0 109754.0 True False 142961.23907813398 113322.33656790969 113803.52255964212 124494.92637050737 122577.20451443855 112056.10349679721 129314.15684534682 132942.71892400726 112982.63077079614 106585.1168448617 1.3412870699970145 1.0632097606352888 1.0677243308302327 1.168032930448573 1.1500405323273595 1.0513297429686992 1.2132477842433482 1.2472915812205747 1.0600225820950804 1.0 16.70164647394885 -4.7515036592133235 24.994701116140067 1.1237613954386327 1.341287511338603 0.4438253114387698 0.07573018904295581 409.91166936271003 1031119.4109387255 0.018881939000436058 0.24895179155403294 1.7721331136987543e-05 4.7515036592133235 0.21752611589997017 DEPPPLS(ph)PAPLTPATPSSLDPFFSR ddPTM_A459_Selumetinib_30min_R1 2 DEPPPLSPAPLTPATPSSLDPFFSR 25 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 DEPPPLS(1)PAPLTPATPSSLDPFFSR;DEPPPLS(1)PAPLTPATPSSLDPFFSR 95.674 4.9842000000000005e-06 21726100.0 4143.91 4661.6900000000005 3239.06 3417.59 4330.38 3580.46 4655.16 4726.2300000000005 2861.85 4114.98 True False 4240.455040354777 4115.897167639116 2799.213442883011 2820.7720626096857 3938.6978935906845 3544.4438231975732 4304.017533309182 4600.875027441355 4856.350428746002 4643.177766299504 0.9132657102065497 0.8864397132310061 0.6028658784507219 0.6075089528303308 0.8482763512045605 0.7633659535767475 0.9269551479480348 0.9908892700242526 1.0459109414232899 1.0 12.180896800899264 -7.434244247443222 1.7949064363957994 1.0220535393018457 0.7589004163858332 0.5559902293209846 0.09852794584675068 0.30013648611983557 1.8861202401195019 0.06456972851541919 0.034670935627254394 3.679219959233222e-08 7.434244247443222 -0.26315312291601256 DEPSVAAMVYPFTGDHK ddPTM_A459_Selumetinib_30min_R2 1 DEPSVAAMVYPFTGDHK 17 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 104.44 0.003906 1890500.0 16166.0 12123.0 15483.0 15647.0 15033.0 12279.0 12440.0 11754.0 8534.3 12557.0 False True 15267.55843762543 13052.795118411139 14486.840636615787 13515.851607419467 13144.420143274849 13970.320792335993 13018.48464939236 11788.202194020554 10241.398468265581 12194.446782995841 1.252009107860046 1.070388460476304 1.1879867036540355 1.1083611948896457 1.0779021285002996 1.1456297313803905 1.0675748462444046 0.9666860993200805 0.8398411711916586 1.0 13.57393668942343 -7.7053836432667175 2.3388155527565795 0.9153009530186469 1.1347293541275325 0.6874646751470153 0.061958149983307224 0.16260677269731608 1.7777829800035898 0.037365098354903044 0.016947462216406743 1.9706811239017972e-08 7.7053836432667175 0.21942840110888562 DEQLS(ph)PEEEEK ddPTM_A459_Selumetinib_30min_R2 2 DEQLSPEEEEK 11 0 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 DEQLS(1)PEEEEK;DEQLS(1)PEEEEK 97.273 0.019403 34828000.0 119510.0 93940.0 102258.0 95755.0 94374.0 93311.0 115329.0 110984.0 75596.0 91588.0 True False 112868.1126364353 101144.89593529151 95678.83161009214 82713.00381341143 82517.8944057353 106163.7432570782 120692.02702007817 111306.94506560983 90717.31232872131 88943.61646579768 1.2689849718426676 1.1371799343709585 1.075724547886856 0.9299487371892263 0.9277551069386376 1.1936072252908936 1.3569498499815218 1.251432643380447 1.019941800585607 1.0 16.440603445709513 -6.887540238705195 21.138414867770507 1.192200914858019 1.0641237891850936 0.09631093076866748 0.1346506655545593 5.712174278418291 1044.5012560385371 0.05021541555087575 0.044285883026992406 1.2955666537633486e-07 6.887540238705195 -0.1280771256729254 DEREDITHTYK ddPTM_A459_Selumetinib_30min_R2 2 DEREDITHTYK 11 1 P21980-2;P21980 P21980-2 TGM2 Protein-glutamine gamma-glutamyltransferase 2 0 ; 86.189 0.026932 12142700.0 124562.0 110056.0 126900.0 126264.0 129693.0 91345.0 105292.0 108273.0 86727.0 117913.0 False True 117639.34270119383 118496.94131418402 118735.39215827321 109066.62538245074 113399.8058698691 103926.94460264928 110188.28663214002 108588.05650443993 104074.82335484706 114508.54531523389 1.0273411680965912 1.0348305533702342 1.036912938081635 0.9524758617987686 0.9903174086937135 0.9075911698689891 0.9622712988694381 0.9482965328526768 0.9088825909746426 1.0 16.80509573934326 -5.763763870829165 24.64655554879278 0.9507491969895706 1.0332084686460796 0.6333945038012602 0.027927134635282524 29.849949991989597 316505.7030575332 0.007537146986011371 0.01180997109471756 1.7228050224130478e-06 5.763763870829165 0.08245927165650901 DESANQEEPEAR ddPTM_A459_Selumetinib_30min_R2 2 DESANQEEPEAR 12 0 P50552;K7EM16 P50552 VASP Vasodilator-stimulated phosphoprotein 0 ; 153.34 0.0065319 5224000.0 14195.400000000001 11021.8 16215.400000000001 14990.5 16156.300000000001 10735.5 10673.8 10613.400000000001 13868.1 14428.199999999999 False True 13406.476496688601 11867.136619327213 15172.118817992618 12948.768039945122 14126.601154845433 12214.217677833947 11170.152849733448 10644.28323685705 16642.107507089506 14011.620377034376 0.9568112849147961 0.8469496246685315 1.082823999632501 0.9241449376667874 1.008206101415616 0.8717205682972652 0.7972063579485631 0.7596753944535544 1.1877361118323335 1.0 13.77433618576316 -6.771858390583227 24.98264049276556 0.900368567806271 0.9617070263668828 0.009326390391955264 0.12457924456825076 728.3684000637343 1746465.7676266495 0.04323520898891004 0.03853423835284765 1.6909922197578238e-07 6.771858390583227 0.06133845856061182 DESTDSGLS(ph)MSSYSVPR ddPTM_A459_Selumetinib_30min_R2 1 DESTDSGLSMSSYSVPR 17 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8;H0YCI3;P46937-4 P46937-6 YAP1 Transcriptional coactivator YAP1 1 DES(0.003)T(0.026)DS(0.037)GLS(0.673)MS(0.13)S(0.13)YSVPR 161.94 1.8453e-05 2497600.0 18467.0 16006.0 21253.0 19830.0 20440.0 12309.0 10831.0 13497.0 12478.0 14055.0 True False 17440.678069258236 17233.60873259824 19885.605118516793 17129.119791341975 17872.144464081528 14004.453020023102 11334.662961219341 13536.27403545136 14973.948664450274 13649.195630724425 1.2777806503116682 1.2626098415503166 1.4569067406253722 1.2549545229452364 1.3093917727907143 1.0260277161314173 0.8304271744559762 0.9917268681372785 1.0970572237050966 1.0 13.736528312836839 -6.79520569811897 4.4374477331766435 0.9731082033056848 1.3164578110457732 0.801080245710208 0.08070905645750136 0.08880727594318956 3.9236128724251778 0.029539535524412266 0.026881819048377553 1.6024862134772865e-07 6.79520569811897 0.3433496077400884 DESTNVDMSLAQR ddPTM_A459_Selumetinib_30min_R1 1 DESTNVDMSLAQR 13 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 201.84 0.012904 10254000.0 1988.1 2714.9 1499.7 1551.2 1511.4 1827.1 1817.8 1940.1 984.36 1515.6 False True 2034.4188618308126 2397.0382458772324 1296.0489772624323 1280.3120396303082 1374.6941368593423 1808.7210328740678 1680.6818824808236 1888.6422456670473 1670.387025190144 1710.142023194166 1.1896198293700597 1.4016603377771493 0.7578604347969301 0.7486583115705029 0.8038479367296749 1.0576437560991443 0.9827732782928066 1.1043774259985042 0.9767533938907784 1.0 10.739900427112214 -5.25528007770344 24.999365444506303 0.9283230101876954 1.295640102319658 0.5773153117310204 0.12549044634748838 377.2630917263588 1531223.7989629926 0.035739769584730206 0.08961969343128923 5.555458686643512e-06 5.25528007770344 0.3673170921319626 DET(ph)PTLEASLDNANSR ddPTM_A459_Selumetinib_30min_R2 2 DETPTLEASLDNANSR 16 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 DET(1)PTLEASLDNANSR;DET(0.991)PT(0.009)LEASLDNANSR 270.78 3.817999999999999e-50 6826100.0 29929.0 16891.6 19452.7 22117.0 25222.0 19756.0 29988.0 25911.0 22502.0 16976.6 True False 28265.66599527969 18187.131404945427 18201.134460498357 19104.626446046925 22053.386872459138 22477.209672887842 31382.501420094708 25986.396720203044 27003.02875841161 16486.441447495996 1.7144795064051106 1.1031568857879719 1.1040062537730235 1.1588083763794028 1.3376681039805993 1.3633754588260003 1.9035339748749216 1.5762283694126076 1.6378931041248384 1.0 14.008992410218093 -7.017430711637317 20.549087749955476 1.585436206145498 1.266068079953854 0.1442823520444425 0.2678182892072876 105.03639174967347 123826.72459844507 0.09701894918745763 0.0772827088753971 9.606590719680688e-08 7.017430711637317 -0.3193681261916441 DETEFYLGK ddPTM_A459_Selumetinib_30min_R1 1 DETEFYLGK 9 0 F8WBS5;F8WB72;C9K025;P18077 F8WBS5 RPL35A 60S ribosomal protein L35a 0 175.44 0.004130600000000001 3118500.0 1685.1 1802.0 1883.4 1799.8 1966.3 1779.1 1822.4 1815.0 1386.3 1761.9 False True 1724.3595513661803 1591.021002272927 1627.644624775666 1485.4987164302643 1788.44851217846 1761.2038692935532 1684.9349007773426 1766.8603040491164 2352.449848654044 1988.057027359332 0.8673591992763849 0.800289418451052 0.8187112353299093 0.7472113203932591 0.8995961823861737 0.8858920267659021 0.8475284549635801 0.8887372342613211 1.1832909299280627 1.0 10.95714342582209 -8.121624073278818 5.011714434270166 1.0882096275253301 0.8385199842967732 0.7434166203614665 0.05861796028835203 0.10734298297003687 3.8420523230949644 0.041617476944004354 0.015004715721886566 7.557461209277544e-09 8.121624073278818 -0.2496896432285569 DETEFYLGK ddPTM_A459_Selumetinib_30min_R2 1 DETEFYLGK 9 0 F8WBS5;F8WB72;C9K025;P18077 F8WBS5 RPL35A 60S ribosomal protein L35a 0 160.88 0.012673 6461500.0 42050.0 29702.0 37066.0 32718.0 41217.0 32354.0 30959.0 33510.0 25864.0 31703.0 False True 39713.029339487155 31980.04789301721 34681.213914409425 28261.75195830189 36038.95197534487 36810.469819630154 32398.654844094697 33607.50855212088 31037.5227005403 30787.652015713702 1.2899012019240061 1.0387296789211116 1.1264650482832692 0.9179573662803965 1.1705651329614535 1.1956244601193513 1.0523262646842557 1.0915905030681767 1.0081159383216058 1.0 14.910064225676848 -6.53473624435779 0.015694974380396028 1.063007218158385e-06 2.1916029121584932 0.18010393549352288 0.09383161424736132 2432.517839054778 12.841025178305674 850.4406928838748 941.3876515993462 2.9191993633578045e-07 6.53473624435779 2.191601849151275 DEVQEVVFVPAGT(ph)HTPGSR ddPTM_A459_Selumetinib_30min_R1 1 DEVQEVVFVPAGTHTPGSR 19 0 J3KS57;J3KT79;J3QR84;J3QRJ1;J3QL71;Q96FV2-2;Q96FV2 J3KS57 SCRN2 Secernin-2 1 DEVQEVVFVPAGT(0.791)HT(0.125)PGS(0.085)R 111.56 0.00082524 8175200.0 5027.5 4595.6 3189.1 4010.8 3853.2 3389.2 3947.2 4301.8 2169.3 3176.9 True False 5144.630968187925 4057.545015563525 2756.037736472375 3310.389072040507 3504.6787403377116 3355.1077251473853 3649.4595260910487 4187.702289784294 3681.1436605967124 3584.6860606265154 1.43516918390582 1.1319108415464325 0.76883657030504 0.923480889554365 0.9776808013489414 0.9359558043308804 1.018069494613766 1.168220094858847 1.0269082419879576 1.0 11.80763106088089 -4.8606353100713475 3.586431623054238 0.9798064422542051 1.451951731344652 0.6785383211838503 0.09573254294188109 0.15520725662074317 3.3486065997052723 0.026561107227174273 0.17156976242207483 1.3783664381437953e-05 4.8606353100713475 0.47214528909044684 DEVQEVVFVPAGTHT(ph)PGSR ddPTM_A459_Selumetinib_30min_R1 3 DEVQEVVFVPAGTHTPGSR 19 0 J3KS57;J3KT79;J3QR84;J3QRJ1;J3QL71;Q96FV2-2;Q96FV2 J3KS57 SCRN2 Secernin-2 1 DEVQEVVFVPAGT(0.274)HT(0.459)PGS(0.267)R;DEVQEVVFVPAGT(0.186)HT(0.496)PGS(0.318)R;DEVQEVVFVPAGT(0.232)HT(0.692)PGS(0.076)R 122.68 0.0005678 42250400.0 14474.5 13156.5 11728.400000000001 11278.400000000001 12128.4 9667.900000000001 10914.2 13456.3 7532.8 10775.7 True False 14811.727687525836 11616.130863709079 10135.747699489706 9308.839161788586 11031.38836144294 9570.649703750863 10090.933106927168 13099.395211777482 12782.611426055822 12158.866059206506 1.2181833088218472 0.9553630089471644 0.8336096187041285 0.7656009299271849 0.9072711474677478 0.7871334100686236 0.8299238644286627 1.0773533607485397 1.0512996330259783 1.0 13.569721068278247 -7.76833063947829 24.996887172457324 1.0482449120576118 0.8900089969045264 0.22231722391597641 0.12177996867481354 245.88525375643374 891889.6021832251 0.06837799788997305 0.03399198088672636 1.7047839992288563e-08 7.76833063947829 -0.15823591515308544 DEVQEVVFVPAGTHT(ph)PGSR ddPTM_A459_Selumetinib_30min_R2 3 DEVQEVVFVPAGTHTPGSR 19 0 J3KS57;J3KT79;J3QR84;J3QRJ1;J3QL71;Q96FV2-2;Q96FV2 J3KS57 SCRN2 Secernin-2 1 DEVQEVVFVPAGT(0.183)HT(0.504)PGS(0.313)R;DEVQEVVFVPAGT(0.248)HT(0.698)PGS(0.054)R;DEVQEVVFVPAGT(0.053)HT(0.835)PGS(0.113)R 116.92 0.00062801 48050800.0 137256.0 112418.0 145251.0 183808.0 187318.0 135827.0 150660.0 147158.0 146989.0 142062.0 True False 129627.86099930208 121040.09911915731 135905.7087973315 158773.03331351434 163785.4381958329 154535.93633525705 157665.98852712626 147586.20541668148 176390.90721581003 137960.30093859634 0.9396026256640099 0.8773545599398924 0.9851073669215951 1.1508602999074449 1.1871925262668923 1.1201478634352808 1.142835927831881 1.069773002904433 1.278562789554355 1.0 17.07389365536291 -5.630420190388037 3.522859526021921 1.1405857813964346 0.9114759194525416 0.6440482092532199 0.06997194490869486 0.12942786738610762 3.097805853999261 0.018359174998042 0.03423249341590712 2.3419618142555515e-06 5.630420190388037 -0.22910986194389305 DEVVS(ph)PLPSALQGPSGSLSAPPAASVISAPPSSSSR ddPTM_A459_Selumetinib_30min_R1 2 DEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSSR 36 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 DEVVS(0.996)PLPS(0.003)ALQGPSGSLSAPPAASVISAPPSSSSR;DEVVS(0.877)PLPS(0.123)ALQGPSGSLSAPPAASVISAPPSSSSR 97.951 6.191100000000001e-14 8929400.0 2364.08 2344.24 2434.11 1885.42 2253.81 1688.74 2586.87 2204.2 1281.1 1921.6100000000001 True False 2419.158464301087 2069.77529099239 2103.5712316091603 1556.1667907167184 2049.953283442475 1671.7528088532383 2391.740313199015 2145.737455749347 2173.9331321580444 2168.2673615664703 1.1157104087723573 0.9545756799553887 0.970162291281934 0.7177006020108432 0.9454338149339115 0.7710086119847676 1.1030652195359782 0.9896092584261167 1.0026130405742402 1.0 11.082326946069793 -7.28135309516807 24.91078119320801 1.0229559727162454 0.9096202835830736 0.20689502196588594 0.10675146728466994 1350.9079990256487 1689892.4655742515 0.04575466644516994 0.03089312276682843 5.231749058565876e-08 7.28135309516807 -0.11333568913317182 DEVVS(ph)PLPSALQGPSGSLSAPPAASVISAPPSSSSR ddPTM_A459_Selumetinib_30min_R2 2 DEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSSR 36 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 DEVVS(0.951)PLPS(0.045)ALQGPS(0.003)GSLSAPPAASVISAPPSSSSR;DEVVS(0.707)PLPS(0.266)ALQGPS(0.013)GS(0.013)LS(0.001)APPAASVISAPPSSSSR 88.94200000000002 1.7710999999999996e-09 14618700.0 41508.0 33235.4 37791.5 44331.0 43889.0 28885.0 35268.3 41516.5 30807.2 33988.1 True False 39201.151529689225 35784.448311345484 35360.03603427409 38293.041324759506 38375.27144736179 32863.64655807678 36908.345832810664 41637.30614157344 36969.50082508833 33006.7752413109 1.187669841815553 1.0841546333965424 1.0712962952532812 1.1601569994281773 1.162648309833423 0.9956636574706949 1.118205143125179 1.2614775553553828 1.1200579443101044 1.0 15.010474573831553 -7.5428662494859 24.989259986742223 1.15242888856642 1.1073705599663821 0.0 0.07923561838210763 760.2917889361671 950539.1748993165 0.03626711136942404 0.020942556347031974 2.865060192195211e-08 7.5428662494859 -0.04505832860003789 DEYQTS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 DEYQTSPPK 9 0 H3BQK9;H3BPE1;Q9UPN3;Q9UPN3-5;A0A5F9ZGX0 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 DEYQT(0.018)S(0.982)PPK 99.568 0.016166 0.0 46440.0 35498.0 44030.0 45568.0 43652.0 35687.0 55674.0 50896.0 50151.0 38832.0 True False 43859.05071404957 38220.58245593981 41197.1577362393 39361.55979081551 38168.04550616865 40602.56031566857 58262.95131593814 51044.098933713634 60182.60133601904 37710.81926234724 1.1630362737263864 1.0135176907732033 1.0924492902060345 1.0437736586146371 1.0121245375402896 1.0766820002823065 1.5449929875724389 1.3535664282074917 1.5958974775207013 1.0 15.202690872720266 -7.242284406852697 22.4892971556319 1.403078037205926 1.0621187632285354 0.4819511106895775 0.15451760663589464 161.56872152180313 189693.09854042288 0.05446291409389755 0.042081913828213434 5.7242104628474125e-08 7.242284406852697 -0.34095927397739056 DEYRQDYDAGR ddPTM_A459_Selumetinib_30min_R1 1 DEYRQDYDAGR 11 1 C9JQX9;B3KSB0;P52298-3;P52298-2;P52298 C9JQX9 NCBP2 Nuclear cap-binding protein subunit 2 0 123.96 0.010461 9537400.0 3639.5 3536.3 5111.4 5037.1 4374.8 3327.0 4129.5 3435.5 1971.1 2894.2 False True 3724.2932687657817 3122.26835201873 4417.299954910443 4157.465043077502 3979.1001124336726 3293.533400674303 3818.0084903204743 3344.3793799232726 3344.8127365519654 3265.6987618953244 1.140427681885852 0.9560797182060506 1.3526354624168582 1.2730705880124167 1.2184528955525307 1.0085233332307797 1.1691245178121095 1.024093042183194 1.0242257416941682 1.0 11.673176003068338 -7.500394752852675 1.0410092210838264 1.0070049430222652 1.1790383998440928 0.2707551724651225 0.10870113613767708 0.8076570192273754 1.625519480627738 0.092910943243594 0.04390897691536847 3.1594046073885294e-08 7.500394752852675 0.17203345682182758 DFDFESANAQFNKEEIDR ddPTM_A459_Selumetinib_30min_R2 1 DFDFESANAQFNKEEIDR 18 1 Q8ND56-3;Q8ND56-2;Q8ND56;A0A140TA76;K7EMZ9 Q8ND56-3;A0A140TA76 LSM14A Protein LSM14 homolog A 0 117.13 0.0020428 0.0 3553.8 4213.1 5855.9 5142.1 5320.1 3699.0 3902.6 4998.6 2864.7 5419.5 False True 3356.2940229885717 4536.231222748326 5479.137769421842 4441.73710938273 4651.7414757025535 4208.503673821225 4084.0786328551944 5013.145098437225 3437.720046405728 5263.024953447951 0.6377119722356194 0.861905703064645 1.041062472225656 0.8439513680194176 0.8838532054945077 0.7996358959050953 0.7759945409682323 0.9525216282991357 0.6531833074729362 1.0 12.361676519722732 -6.750922274050586 24.81395928886506 0.8295326395839462 0.86402075547362 0.0 0.12743808754506922 1220.3728943996177 2879329.6777482145 0.04174044107352033 0.04131683798897183 1.774507037083946e-07 6.750922274050586 0.03448811588967382 DFLDGVYAFEYYPS(ph)TPGR ddPTM_A459_Selumetinib_30min_R1 1 DFLDGVYAFEYYPSTPGR 18 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 DFLDGVYAFEYYPS(0.648)T(0.352)PGR 141.55 0.00030883 30779000.0 2762.3 2773.9 2120.2 2099.7 2542.5 1786.9 2486.8 2128.5 1282.7 2318.7 True False 2826.656215499854 2449.130498448877 1832.288485424958 1733.0268112504873 2312.5313239148322 1768.9254083753874 2299.218673865834 2072.045265657602 2176.6482152986673 2616.327731050616 1.0803907255016474 0.9360946908074858 0.7003283509475252 0.6623890389124036 0.8838844218442806 0.676110025277703 0.8787961257982602 0.7919670158545271 0.8319478440969662 1.0 11.353327554223954 -4.988840176083367 3.79385797443592 0.7921006769226496 1.067355777630931 0.42994738943749866 0.10021086495371469 0.18497357383883475 5.810714832105534 0.024571850116904437 0.1068103192844978 1.0260294439982809e-05 4.988840176083367 0.2752551007082814 DFLLKPELLR ddPTM_A459_Selumetinib_30min_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;F6R6M7;A0A0G2JJL7;F6QYI9;A0A0G2JHN7;K7ENP6;F6SXL5;K7EN69;F6U6E2;K7EIL8;K7EL56;F6S2B7;Q13838;Q13838-2;F6S4E6;A0A0A0MT12;F6TRA5;F6WLT2;Q5STU3 O00148;Q13838 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 106.88 0.032775 7508400.0 2873.8 3555.2 3617.4 3699.7 3997.3 3367.8 2778.6 3331.7 2235.7 3044.1 False True 2940.753948558621 3138.9555312323614 3126.176948955873 3053.616846970248 3635.7449207806344 3333.922989717741 2569.007964936307 3243.3324931131906 3793.81961093259 3434.8398870449746 0.8561545938866395 0.9138578898746965 0.910137605175347 0.8890128644678409 1.0584903635518512 0.9706196211043615 0.7479265553616384 0.9442456125381321 1.1045113413412841 1.0 11.746027134928188 -1.522878747570903 0.09142227466745767 1.0631192261204057 0.5535927263971043 0.15470143276457382 0.0890225902917444 357.4129447969762 2.3538955791302776 1.6833877877286594 22.82825503223957 0.029999999841773352 1.522878747570903 -0.5095264997233013 DFLQLRS(ph)ENQNK ddPTM_A459_Selumetinib_30min_R1 1 DFLQLRSENQNK 12 1 Q9BR77;F5H0W5;Q9BR77-2 Q9BR77 CCDC77 Coiled-coil domain-containing protein 77 1 DFLQLRS(1)ENQNK 68.044 0.038751 16335000.0 653.53 1087.7 1155.3 1220.0 946.37 1023.1 895.98 700.49 525.34 692.72 True False 668.7559774519854 960.3515783419884 998.4166056086468 1006.9499022363169 860.771000595194 1012.808542900475 828.3955072423638 681.9107296878046 891.4636106844957 781.6373596642009 0.8555834354428626 1.2286408351240592 1.2773399240250958 1.2882571307350412 1.1012408631094472 1.2957524744410727 1.0598207685444445 0.8724131737776202 1.1405079346098264 1.0 9.610355614750118 -7.510485047989515 23.642900747508087 0.9970997196457414 1.1829790225652446 0.24616466735718823 0.1359339442558433 376.3449850683252 717944.4430755774 0.05873216800191405 0.0372864983097761 3.086845918639109e-08 7.510485047989515 0.18587930291950316 DFLSNEASLGAIGT(ph)SLPSR ddPTM_A459_Selumetinib_30min_R2 2 DFLSNEASLGAIGTSLPSR 19 0 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 DFLSNEASLGAIGT(0.491)S(0.491)LPS(0.017)R;DFLSNEASLGAIGT(0.425)S(0.425)LPS(0.15)R 85.054 0.0090783 9075800.0 40417.0 27569.0 33476.0 42319.0 39556.0 36509.0 46241.0 43146.0 41887.0 37679.0 True False 38170.7849420702 29683.45365169318 31322.190605912958 36555.07919565308 34586.62164487324 41537.783354295505 48391.29812480321 43271.547716795176 50265.57042056647 36591.10936820104 1.0431710216264158 0.8112203801475651 0.8560054927750577 0.9990153298664601 0.9452192688896781 1.1351878658916337 1.3224878655047543 1.1825699866427026 1.3737099336006746 1.0 15.159205535476252 -6.842661808003502 2.7768008325075635 1.235955714382879 0.9187547932969812 0.6047589153997748 0.11101214697319073 0.16614853307433072 2.600373523337327 0.04048486394798576 0.03583542258584579 1.4366077070797218e-07 6.842661808003502 -0.3172009210858978 DFMIQGGDFTR ddPTM_A459_Selumetinib_30min_R1 4 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 ;;; 195.36 0.0030497 98014300.0 8248.6 9223.0 6119.4 7073.6 7596.5 6386.7 7264.200000000001 7214.5 4360.01 6871.9 False True 8440.776331018391 8143.166872343628 5288.41909145811 5838.328547917061 6909.397916271005 6322.455596659626 6716.255545559031 7023.148024001295 7398.618527468896 7753.975302974393 1.0885740541088058 1.0501925211471774 0.6820268165452493 0.7529464977374253 0.8910781433132225 0.8153824779702816 0.8661693238799333 0.9057480517518858 0.9541710204610552 1.0 12.920720424660503 -9.97547750815946 9.938039283982997 0.9999991508619577 0.8818348347643487 0.07019274617624749 0.11754658283497314 0.0 0.0 0.12218832039284072 0.02963502065861734 1.058089712384022e-10 9.97547750815946 -0.11816431609760902 DFMIQGGDFTR ddPTM_A459_Selumetinib_30min_R2 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 ; 158.08 0.007875700000000001 9604500.0 42157.0 27228.0 34547.0 40340.0 40146.0 31863.0 33318.0 35618.0 29022.0 29229.0 False True 39814.0827078421 29316.30004818102 32324.28363192956 34845.622409618525 35102.50057020633 36251.83902648437 34867.3530183645 35721.642483122676 34827.210942432735 28385.08282393769 1.402641061672933 1.0328065706208902 1.1387771468706043 1.2276033374907942 1.2366530965554805 1.2771440284793705 1.2283689018853305 1.2584653250684872 1.2269547056971162 1.0 14.792845330762727 -10.570203587639575 4.010177009681775 0.9999686052970028 1.2202370861261724 0.36211965124333456 0.0895387784161264 62903924.283411734 107254479.17233561 27144.859030943608 0.022169433940422607 2.6902733676804324e-11 10.570203587639575 0.2202684808291696 DFPYEEDSRPR ddPTM_A459_Selumetinib_30min_R1 2 DFPYEEDSRPR 11 1 H0Y6J6;Q5W012;Q96I25;Q5W011;Q5W010 H0Y6J6 RBM17 Splicing factor 45 0 ; 157.38 0.0015765999999999998 8330800.0 4394.0 4739.9 5060.799999999999 5563.9 4845.7 4351.0 4806.0 4408.5 2678.7 3854.5 False True 4496.371650764345 4184.950304480274 4373.57115698454 4592.269312338231 4407.40729057782 4307.232890391912 4443.4795506672035 4291.572259173847 4545.558255492747 4349.262621009447 1.0338239013308317 0.9622206496026592 1.0055891166143127 1.0558730783822807 1.0133688568925456 0.9903363548536925 1.0216627363918276 0.9867355993733461 1.0451330838324362 1.0 12.086555110177965 -5.521570602073768 24.998082997551414 1.0158805702649474 0.9944929246250952 0.07126908836563839 0.0261484352297781 104.39064859639203 1994873.0601732335 0.0068608968458660075 0.01210774454673038 3.0090499560347384e-06 5.521570602073768 -0.021387645639852182 DFQDYMEPEEGCQGS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 5 DFQDYMEPEEGCQGSPQR 18 0 O43237-2;O43237;H3BUM4;B4E2E0 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR 283.83 2.524999999999999e-67 151988800.0 8886.26 10603.08 9350.210000000001 10041.36 10232.28 8356.92 10247.640000000001 8636.67 4518.33 8308.74 True False 9093.292568348012 9361.666464361837 8080.502839027115 8287.824975671856 9306.77208065576 8272.856972276259 9474.652264377703 8407.597455742092 7667.276004233592 9375.247712981201 0.9699255792203989 0.9985513717572967 0.8618975291542057 0.8840113060902196 0.9926961255401682 0.88241476124641 1.0106028719922635 0.8967866997370878 0.8178211647269107 1.0 13.194641094578579 -7.962705709278819 24.99941217464769 0.8917080087603522 0.9402592738715368 0.056227786400215085 0.06466274754734459 372.2933285536383 249558.25343956353 0.034431446245271655 0.01654027427186784 1.0896682344741064e-08 7.962705709278819 0.04855126511118468 DFQDYMEPEEGCQGS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 9 DFQDYMEPEEGCQGSPQR 18 0 O43237-2;O43237;H3BUM4;B4E2E0 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 DFQDYMEPEEGCQGS(1)PQR;DFQDY(0.001)MEPEEGCQGS(0.999)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR;DFQDYMEPEEGCQGS(1)PQR 265.42 2.3537999999999997e-43 235418400.0 407625.0 349977.0 419179.0 482093.0 491893.0 365883.0 400926.0 408888.0 364069.0 400504.0 True False 384970.8343521632 376819.1105465795 392209.47950758756 416431.10174318834 430097.0037607857 416280.0620948179 419569.8534197979 410077.79638494714 436892.9729377899 388940.40888563916 0.9897938747355944 0.9688350758570224 1.0084050680959447 1.0706809892454048 1.105817225299539 1.0702926530249457 1.0787509958708477 1.054346082372539 1.123290259784373 1.0 18.569189605507212 -5.66771905226456 3.195156422228991 1.0763149952609494 0.9805743033085388 0.6048872581121754 0.031129597404653764 0.14500742473058564 2.930668537878456 0.008232442828482392 0.01528987575640095 2.1492203682132726e-06 5.66771905226456 -0.09574069195241064 DFQDYMEPEEGCQGS(ph)PQRR ddPTM_A459_Selumetinib_30min_R1 8 DFQDYMEPEEGCQGSPQRR 19 1 O43237-2;O43237;H3BUM4;B4E2E0 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 DFQDYMEPEEGCQGS(1)PQRR;DFQDY(0.002)MEPEEGCQGS(0.998)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDY(0.001)MEPEEGCQGS(0.999)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDYMEPEEGCQGS(1)PQRR 122.47 0.00021581 217250400.0 17825.69 21849.08 24088.39 25354.510000000002 23909.71 20166.38 21084.030000000002 20281.47 11106.460000000001 17043.13 True False 18240.993894245217 19290.97955623829 20817.31894605494 20926.820791598147 21747.08095210216 19963.524526808025 19493.644642250056 19743.53953210086 18846.85143625637 19230.781749644484 0.9485310650245633 1.003130283905121 1.0824998805074466 1.0881939727689447 1.1308474733485128 1.038102599608416 1.0136688615173135 1.0266633873303592 0.9800356367002494 1.0 14.231129790350577 -9.906562077891408 9.382686046792974 1.0000022505602943 1.0387684100329089 0.03376917179730754 0.0514521496276112 0.0 0.0 0.054433328572544716 0.013202021368150218 1.240046360685427e-10 9.906562077891408 0.038766159472614525 DFQDYMEPEEGCQGS(ph)PQRR ddPTM_A459_Selumetinib_30min_R2 6 DFQDYMEPEEGCQGSPQRR 19 1 O43237-2;O43237;H3BUM4;B4E2E0 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 DFQDY(0.005)MEPEEGCQGS(0.995)PQRR;DFQDY(0.004)MEPEEGCQGS(0.996)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDYMEPEEGCQGS(1)PQRR;DFQDYMEPEEGCQGS(1)PQRR 134.09 0.00010966 398078400.0 336084.0 354205.0 422127.0 434517.0 472796.0 304005.8 301850.9 306206.0 279488.0 374532.0 True False 317405.79673084884 381371.38455141545 394967.8083971262 375335.03501636605 413399.1396301313 345879.8394601138 315887.56495621154 307097.00876486796 335393.40954719257 363718.28800899873 0.87266933556829 1.0485350809249931 1.085916824691956 1.0319388587001155 1.1365915689669788 0.9509553158667579 0.8684951386013238 0.8443265540644744 0.9221241290426799 1.0 18.472461941766156 -6.990832193744087 23.890476764520983 0.8977581633705933 1.039044674562344 0.39635158569453166 0.07368314858657747 107.2738495953167 279543.32539626554 0.025931549815242583 0.022832373310879287 1.0213340388809472e-07 6.990832193744087 0.14128651119175073 DFQESS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 DFQESSPQK 9 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 DFQES(0.427)S(0.573)PQK;DFQES(0.407)S(0.593)PQK 125.23 0.0050952 18117800.0 173155.0 138033.0 144022.0 160503.0 167163.0 160884.0 201425.0 201222.0 165184.0 141552.0 True False 163531.7382943853 148619.68725395072 134755.78131929715 138642.21451688153 146162.489483819 183044.310640458 210791.66161606583 201807.52270590456 198225.4156265873 137465.02596373585 1.1896243218804323 1.081145449266183 0.9802913895702212 1.0085635494911718 1.063270373384846 1.3315700437778715 1.533420301915005 1.468064486156229 1.4420061702012874 1.0 17.06870508735203 -6.81575572264749 4.1308949849116114 1.403238562169257 1.0559006768415913 0.48909243812577985 0.1457506841819732 0.15774421098019076 5.50859159521833 0.05046877194659563 0.04544950083732179 1.528425509072451e-07 6.81575572264749 -0.34733788532766563 DFQEYVEPGEDFPAS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 4 DFQEYVEPGEDFPASPQR 18 0 Q9Y6G9;E9PHI6;C9JGM7 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR 312.46 1.2424999999999993e-111 120640600.0 12585.7 15710.900000000001 10989.2 11085.3 11881.5 11399.2 13219.0 12302.400000000001 6735.900000000001 12081.4 True False 12878.922322490856 13871.46052420075 9496.926999354746 9149.460451852656 10806.820422849198 11284.534397645484 12221.880187322036 11976.100388172934 11430.330329329 13632.165372801526 0.9447451648574102 1.0175537154116878 0.696655794559441 0.671167067126942 0.792744228617607 0.8277873755962525 0.8965472361204444 0.8785178334226548 0.8384823699494168 1.0 13.734727121771725 -9.199703155320986 0.6502474795567246 1.003760427433336 0.827677813935737 0.18978752827798084 0.09922492873819037 4.572634366486871 2.8421781235798877 0.16375967702281571 0.043705958506805496 6.313887576393677e-10 9.199703155320986 -0.17608261349759902 DFQEYVEPGEDFPAS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 7 DFQEYVEPGEDFPASPQR 18 0 Q9Y6G9;E9PHI6;C9JGM7 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR;DFQEYVEPGEDFPAS(1)PQR 194.15 1.8195e-10 140869300.0 176755.7 158821.2 192515.8 206614.7 216894.2 194841.7 216475.3 213047.0 202350.6 182646.2 True False 166932.32580312918 171002.27534935254 180129.54302335426 178473.42142976265 189646.01153725034 221679.3755781491 226541.83038766947 213666.9314981706 242826.37414815792 177372.72963418125 0.9411386189264569 0.9640843646147448 1.0155424872518946 1.0062055300036905 1.0691948639928013 1.2497940130669871 1.2772077807839797 1.2046210933261476 1.3690175183579245 1.0 17.43642469238595 -6.589199679414673 2.61232045648766 1.2378359770268192 0.9830348143033575 0.6074969500932381 0.09009617778653305 0.17340789122232686 2.402039963885008 0.030404459813008662 0.031200845514371457 2.5751368913112755e-07 6.589199679414673 -0.25480116272346176 DFQEYVEPGEDFPAS(ph)PQRR ddPTM_A459_Selumetinib_30min_R1 7 DFQEYVEPGEDFPASPQRR 19 1 Q9Y6G9;E9PHI6;C9JGM7 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR 152.28 9.056e-06 1145417600.0 17347.5 19854.499999999996 23222.9 24594.399999999994 20312.9 18172.07 19290.0 18034.5 10844.95 15321.890000000001 True False 17751.662997640986 17529.92590989337 20069.357734258676 20299.449734066286 18475.60178153378 17989.275474719412 17834.93976953189 17556.166475688045 18403.088066191085 17288.603829347107 1.0267840696024189 1.0139584481736241 1.1608431734777385 1.1741520561428054 1.0686578259241366 1.0405279484849395 1.0316009288880452 1.0154762437141833 1.064463518734356 1.0 14.077533745938146 -6.6670771144680865 3.760159540446277 1.0310406405595551 1.09564493024196 0.2675723827141958 0.04937481557578974 0.3541201019646772 9.592648677701941 0.018972198571800537 0.01867096684135432 2.152399515084179e-07 6.6670771144680865 0.06460428968240484 DFQEYVEPGEDFPAS(ph)PQRR ddPTM_A459_Selumetinib_30min_R2 7 DFQEYVEPGEDFPASPQRR 19 1 Q9Y6G9;E9PHI6;C9JGM7 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR;DFQEYVEPGEDFPAS(1)PQRR 137.9 7.9258e-05 418548300.0 288927.9 268719.3 282938.1 324677.8 338093.0 242039.4 225232.1 240473.1 215449.5 287293.1 True False 272870.44398802414 289329.20624126453 264734.1706857115 280456.12353955436 295618.734750231 275378.1303350865 235705.83893893936 241172.83690853498 258545.42016200343 278998.2017258818 0.978036569053308 1.0370289286865477 0.9488741111880541 1.0052255598948447 1.0595721869228354 0.9870247500937227 0.8448292407652235 0.8644243418654342 0.9266920666966398 1.0 18.089896297675814 -7.123724344819852 6.207703921653806 0.8982500642509607 1.0060048242545923 0.47420107940042666 0.04805194640373075 0.18652711662709853 8.679996729961537 0.01811515473062055 0.014010223506104393 7.52100115166926e-08 7.123724344819852 0.1077547600036316 DFQHLISS(ph)PLKK ddPTM_A459_Selumetinib_30min_R1 1 DFQHLISSPLKK 12 1 Q15361 Q15361 TTF1 Transcription termination factor 1 1 DFQHLIS(0.159)S(0.841)PLKK 75.998 0.024946 11776000.0 3213.7 2925.2 3041.8 2897.7 2775.0 2483.9 2467.2 2521.1 1631.2 2872.5 True False 3288.57295722835 2582.7162241114142 2628.740267411392 2391.671091565718 2524.001739966042 2458.9142212007514 2281.0971176458834 2454.2322383130745 2768.027261865743 3241.2133555194255 1.0146116890541241 0.7968362279247481 0.8110358619049066 0.7378937543537418 0.7787212574784527 0.7586400373839921 0.7037787604328574 0.7571955218973137 0.8540095816747456 1.0 11.662318275024344 -4.758420979721894 4.961066210624483 0.7847251478226696 1.0302930198400309 0.38973400793092505 0.07877813990224813 0.16532785862178123 10.509198975735387 0.018367508617224807 0.1426603534505052 1.744130674768003e-05 4.758420979721894 0.2455678720173613 DFS(ph)PLQTQTFNR ddPTM_A459_Selumetinib_30min_R1 1 DFSPLQTQTFNR 12 0 Q6P4F7-3;Q6P4F7 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 DFS(0.996)PLQT(0.004)QT(0.001)FNR 103.3 0.010825 6890600.0 887.88 1172.5 1213.0 1570.7 1156.3 972.91 1159.9 998.27 639.7 951.06 True False 908.5658764862649 1035.2231549195385 1048.2812625320594 1296.406730690642 1051.7128691613457 963.123408731601 1072.4078091591527 971.7926367620453 1085.5241781605669 1073.1378151088963 0.8466441716007076 0.964669346606232 0.976837501924844 1.2080524164168882 0.9800352334565933 0.8974834314583056 0.9993197463182587 0.9055618235421449 1.0115421923235588 1.0 10.067619647249344 -4.756131390691149 2.615533057457413 0.9965603994972831 0.8103204628971776 0.24278534299301868 0.0798222852767943 0.8547719828706779 7.213511996655561 0.022009045001045936 0.3651714440522104 1.7533499661673554e-05 4.756131390691149 -0.18623993660010552 DFSASYFSGEQEVT(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 DFSASYFSGEQEVTPSR 17 0 P49454 P49454 CENPF Centromere protein F 1 DFSASYFSGEQEVT(1)PSR;DFSASYFSGEQEVT(0.981)PS(0.018)R 260.07 7.884699999999999e-40 23864800.0 2613.9 2629.8 2903.4 3098.0 2822.5 2397.7 2904.3999999999996 2520.1000000000004 1266.37 2298.42 True False 2674.798784235988 2321.901793439148 2509.1342272346114 2556.992456662386 2567.205373352848 2373.581314937415 2685.318769654143 2453.258761561531 2148.937397994679 2593.444595506687 1.0313691639567903 0.8952964707485925 0.9674909699562702 0.9859445083548509 0.989882482086064 0.9152234518716151 1.0354255395725955 0.9459460849142345 0.8286035497800316 1.0 11.340653833988831 -8.008210376450435 24.920727062823918 0.9052927837679214 0.9713252600918874 0.1484757625942763 0.056626315455275765 560.3692926075946 1700863.5385456102 0.030938095139873636 0.013741459575777706 9.812724899806764e-09 8.008210376450435 0.06603247632396592 DFSASYFSGEQEVTPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 DFSASYFSGEQEVTPSR 17 0 P49454 P49454 CENPF Centromere protein F 1 DFSASYFSGEQEVT(0.419)PS(0.581)R 166.67 1.4407e-06 4523700.0 20107.0 17242.0 19030.0 24238.0 24237.0 19022.0 15105.0 18564.0 21769.0 20191.0 True False 18989.533434698413 18564.405958231862 17805.63051829738 20936.74258711785 21192.131378470858 21642.107835476443 15807.41242998968 18618.018166564354 26123.408276680402 19608.033367481807 0.96845680945193 0.9467755184984177 0.9080783464917215 1.0677635127773493 1.0807882147740597 1.1037367914401843 0.8061702126744071 0.9495097145969108 1.3322808966657396 1.0 14.259157223939237 -5.76351483514648 24.99707859069351 1.0400397108537462 0.9416707481907021 0.13051296146706626 0.12580027569542546 127.52414419473794 1535949.2678400124 0.03607163316424567 0.05659360944947013 1.7237932066465147e-06 5.76351483514648 -0.09836896266304418 DFSETYER ddPTM_A459_Selumetinib_30min_R2 1 DFSETYER 8 0 Q96MH2;O94992 Q96MH2;O94992 HEXIM2;HEXIM1 Protein HEXIM2;Protein HEXIM1 0 134.48 0.03874 8630100.0 33046.0 25933.0 44185.0 40624.0 41238.0 35197.0 25676.0 33031.0 27482.0 33425.0 False True 31209.435613619327 27921.977712262298 41342.18520499053 35090.9411196912 36057.313767602456 40045.06726344569 26869.984876028775 33127.11474142358 32979.167911237564 32459.93340142038 0.9614756514643269 0.860198244000109 1.2736374007218842 1.0810540085136369 1.11082525406613 1.2336768152978836 0.8277892792858594 1.020553995960263 1.01599616682499 1.0 14.98637241943721 -7.263749222837222 24.999908986064728 0.9677977042062231 1.0858325891285958 0.18912837418705797 0.12243252066149254 406.17264756232873 4396050.869934111 0.05187908340133896 0.03683932927585309 5.44817158938571e-08 7.263749222837222 0.11803488492237268 DFSNSPLHR ddPTM_A459_Selumetinib_30min_R2 2 DFSNSPLHR 9 0 O95758-1;O95758-6;O95758-2;O95758;O95758-5;O95758-4;O95758-7 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 ; 119.75 0.0095525 2345400.0 11204.099999999999 9938.2 17461.800000000003 26480.0 26700.0 16167.8 12820.4 18040.0 15257.5 19217.199999999997 False True 10581.420975565949 10700.427983650383 16338.326798970327 22873.378319452106 23345.70729897147 18394.767693324353 13416.574003140664 18092.493413317236 18309.42633016911 18662.34950371805 0.5669929701754777 0.5733698204247308 0.8754699827969294 1.225643015360692 1.2509522069726733 0.9856619441008546 0.7189113032347677 0.9694649331110595 0.9810890277519114 1.0 14.187843005824064 -5.364109858445988 3.612332270259159 1.0151690702571252 0.5658899350820767 0.614828887237477 0.13970853423208482 0.1715195382508654 4.071434527705288 0.04295267021061422 0.10079445584881098 4.324044368563236e-06 5.364109858445988 -0.44927913517504847 DFT(ph)PVCTTELGR ddPTM_A459_Selumetinib_30min_R1 1 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 1 DFT(0.989)PVCT(0.006)T(0.006)ELGR 173.59 5.9762e-08 0.0 1704.0 1982.2 2385.3 2286.3 1943.5 1898.6 1652.8 2066.8 1211.8 1862.4 True False 1743.6998845931819 1750.1231025002216 2061.3893615150237 1887.0406241663038 1767.7107681527941 1879.5018077908733 1528.1279653230852 2011.981750087446 2056.336093629786 2101.4571813122297 0.8297575130721195 0.8328140673355896 0.9809333161039302 0.8979676773561305 0.8411833388149115 0.8943802540945616 0.7271753994858291 0.9574221963595224 0.978528666639656 1.0 11.03717434551179 -7.976609572019737 24.999461769464013 0.9821681456682321 0.8623039402907436 0.4546375755894436 0.06110619164196404 210.13998885255924 224595.48345092213 0.03436027661988446 0.01650479797073527 1.0553352097128064e-08 7.976609572019737 -0.11986420537748843 DFT(ph)PVCTTELGR ddPTM_A459_Selumetinib_30min_R2 2 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 1 DFT(0.959)PVCT(0.039)T(0.002)ELGR;DFT(0.999)PVCT(0.001)TELGR 128.35 0.0057598 11607600.0 53997.0 52255.0 50374.0 56133.0 49963.0 39650.0 54523.0 42425.0 33899.0 44865.0 True False 50996.062907117426 56262.79047369243 47132.991683064276 48487.58856517393 43686.20126511279 45111.42759313639 57058.42753527487 42548.44972616316 40679.74721719824 43569.6308767308 1.1704497348485194 1.291330436855747 1.0817854256423494 1.1128758171570754 1.0026754963500102 1.0353869584244977 1.3095917130146728 0.9765620885461066 0.9336720646610766 1.0 15.411035270297004 -1.5228787453402617 0.20257757249543235 0.9848446610731627 2.186752017168938 0.2993425983261453 0.1031348281907286 71.06224366603233 0.865478603811198 0.19533077178807218 27.213618256262887 0.029999999995860588 1.5228787453402617 1.2019073560957754 DFTNEAPPAPLPDAS(ph)ASPLSPHR ddPTM_A459_Selumetinib_30min_R2 2 DFTNEAPPAPLPDASASPLSPHR 23 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDAS(0.497)AS(0.497)PLS(0.006)PHR;DFTNEAPPAPLPDAS(0.491)AS(0.491)PLS(0.018)PHR 171.29 1.1192e-12 12407000.0 81297.0 74908.0 98649.0 104139.0 106062.0 72375.0 67821.0 78726.0 72948.0 75577.0 True False 76778.83819767622 80653.20273281723 92302.03074090992 89955.0885502047 92737.5433536897 82343.99929516381 70974.8108847619 78955.07962620919 87539.63833741916 73394.89563737159 1.0461059659655891 1.0988938949011846 1.2576083110323424 1.225631398055983 1.263542138023957 1.1219308724411547 0.9670265250520035 1.0757570937399963 1.1927210683687557 1.0 16.163392111627246 -6.999850380430998 24.999995251306867 1.0622306065074216 1.1821475970936348 0.3117610478208269 0.0835439572452571 6.988775765650822 1167459.1490877778 0.03157993170795543 0.027579412270957695 1.0003445711402057e-07 6.999850380430998 0.11991699058621319 DFTNEAPPAPLPDAS(ph)ASPLSPHRR ddPTM_A459_Selumetinib_30min_R1 1 DFTNEAPPAPLPDASASPLSPHRR 24 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDAS(0.704)AS(0.056)PLS(0.241)PHRR 85.884 5.2294e-05 8094900.0 852.88 869.83 704.41 910.08 836.32 734.18 796.84 674.71 449.38 777.72 True False 872.750444584409 767.9898992270038 608.7549910471624 751.1516123173997 760.6750036642886 726.7948157821041 736.7337172604358 656.8144990330471 762.5650385833911 877.5479376343145 0.994533070110291 0.8751543548690272 0.6936999848558 0.8559664721477748 0.8668187469221444 0.8282109553369709 0.8395367200639952 0.7484656630880833 0.868972515209946 1.0 9.77733412715578 -8.548285665199257 22.515589312721445 1.000000002647216 0.8338744784339277 0.29451887229515583 0.07489745199696327 2466.483186892617 2185793.5313630337 0.07338156528454111 0.018947038702809716 2.829530207913068e-09 8.548285665199257 -0.1661255242132883 DFTNEAPPAPLPDAS(ph)ASPLSPHRR ddPTM_A459_Selumetinib_30min_R2 1 DFTNEAPPAPLPDASASPLSPHRR 24 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDAS(0.596)AS(0.404)PLSPHRR 121.49 7.6721e-08 201600000.0 8584.2 7946.9 8730.1 9659.4 8216.9 6353.1 5937.5 4886.3 4472.4 6700.2 True False 8107.124529275283 8556.40167668905 8168.4148706141905 8343.773056605582 7184.619561981977 7228.181857300246 6213.605514933052 4900.518324029488 5367.004969296956 6506.747816789738 1.2459564681999815 1.3150043489637746 1.2553759728534057 1.282326177614516 1.1041798090657653 1.110874750462735 0.9549479540147117 0.7531440378531956 0.8248367879646669 1.0 12.667720924682483 -6.9913480592361985 1.1735334997750984 0.840512761928472 1.2757816615395852 0.8495407766055312 0.0725431002148175 0.16234473403193173 0.45925347726983057 0.04178308422256075 0.03031330208805555 1.0201215938296597e-07 6.9913480592361985 0.43526889961111315 DFTNEAPPAPLPDASAS(ph)PLSPHR ddPTM_A459_Selumetinib_30min_R1 2 DFTNEAPPAPLPDASASPLSPHR 23 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDAS(0.315)AS(0.541)PLS(0.144)PHR;DFTNEAPPAPLPDAS(0.062)AS(0.83)PLS(0.108)PHR 146.34 9.2916e-08 60551000.0 6604.3 8177.8 6864.1 7409.5 8380.8 6757.6 8438.1 6952.780000000001 3907.91 6451.88 True False 6758.167340269229 7220.33937424392 5931.992921802403 6115.569918540979 7622.758119750414 6689.62467940988 7801.607323446716 6768.369688587674 6631.437847546441 7280.041644633137 0.9283143792523996 0.991799185594875 0.8148295313908651 0.8400460075732384 1.047076169594432 0.918899232443469 1.0716432273705574 0.9297157927080446 0.9109065814802243 1.0 12.829730987879172 -6.255355108168398 24.882289789582178 0.9777490630626932 0.8951140053090372 0.2855936489833629 0.06654641805131967 684.0870997733608 2797648.7752581905 0.020457659938768497 0.02574094356320715 5.55449898611483e-07 6.255355108168398 -0.08263505775365598 DFTNEAPPAPLPDASAS(ph)PLSPHR ddPTM_A459_Selumetinib_30min_R2 1 DFTNEAPPAPLPDASASPLSPHR 23 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDAS(0.328)AS(0.668)PLS(0.004)PHR 165.9 2.5883e-12 13243000.0 45049.0 36623.0 52076.0 52890.0 57513.0 42206.0 37070.0 42504.0 38835.0 37482.0 True False 42545.35692543537 39431.86633849466 48725.48685606176 45686.29075966095 50287.702767256436 48019.49339207855 38793.82845281149 42627.679603084 46603.08514056148 36399.797270068506 1.1688349967932472 1.0832990647153802 1.3386197317128645 1.2551248684351524 1.381537990284576 1.3192241988546705 1.0657704537467738 1.1710966214126877 1.2803116675290696 1.0 15.151642794855803 -10.56344035909266 0.47559236181320486 0.9176660521037098 1.2373344063021705 0.31321688401965975 0.10112829302339822 25.930234798535043 3.6582273333592337 3.036503194089355 0.05621129154193154 2.7324966671376785e-11 10.56344035909266 0.31966835419846074 DFTNEAPPAPLPDASASPLS(ph)PHR ddPTM_A459_Selumetinib_30min_R1 1 DFTNEAPPAPLPDASASPLSPHR 23 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFT(0.002)NEAPPAPLPDAS(0.224)AS(0.17)PLS(0.604)PHR 67.033 0.0024753 119700000.0 1441.0 2016.8 1867.0 1834.1 2076.7 1680.5 2035.4 1561.6 761.83 1322.9 True False 1474.5724963020998 1780.6721184151174 1613.4716546969134 1513.8088653210073 1888.862851671163 1663.5956957719177 1881.8681392900592 1520.1812952083196 1292.7698681382906 1492.7071011372154 0.9878511967811369 1.1929146160412292 1.0809030475353765 1.014136573858137 1.2653941622118212 1.1144823351510227 1.2607082379767351 1.0184056162459287 0.8660572909135335 1.0 10.543715392403918 -7.994304562405899 24.566924655382675 0.9360962212521976 1.1320041341020364 0.434777961433758 0.09200437111778811 98.64493082796994 425499.0506562134 0.049045216503888156 0.02344239469676334 1.0132005983523985e-08 7.994304562405899 0.19590791284983877 DFTNEAPPAPLPDASASPLS(ph)PHRR ddPTM_A459_Selumetinib_30min_R1 2 DFTNEAPPAPLPDASASPLSPHRR 24 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDASAS(0.004)PLS(0.995)PHRR;DFTNEAPPAPLPDAS(0.001)AS(0.009)PLS(0.99)PHRR 212.51 2.4028e-32 424380000.0 7818.8 8987.3 8592.6 8733.1 9666.0 7117.8 8733.900000000001 7396.8 3976.7 6359.7 True False 8000.962827263601 7935.062737917579 7425.772115773276 7208.028025590147 8791.712006670905 7046.201394445314 8075.094891296766 7200.61283580744 6748.169453323625 7176.029443723903 1.114956800276395 1.105773436431134 1.0348023477339263 1.0044590928893458 1.22514993501874 0.9819080941213061 1.1252873130780112 1.003425765219656 0.940376500158527 1.0 12.808970094404673 -7.927642063154273 5.546577837408974 0.9704561743464117 1.0815820423638651 0.3430362743356692 0.06643061229684225 0.21645346184793313 11.771994000429974 0.036421139399307904 0.016929078105051277 1.1812938333565507e-08 7.927642063154273 0.11112586801745339 DFTNEAPPAPLPDASASPLS(ph)PHRR ddPTM_A459_Selumetinib_30min_R2 4 DFTNEAPPAPLPDASASPLSPHRR 24 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DFTNEAPPAPLPDAS(0.001)AS(0.014)PLS(0.986)PHRR;DFTNEAPPAPLPDAS(0.003)AS(0.015)PLS(0.982)PHRR;DFTNEAPPAPLPDAS(0.017)AS(0.121)PLS(0.862)PHRR;DFTNEAPPAPLPDAS(0.044)AS(0.107)PLS(0.849)PHRR 191.46 9.0847e-27 341974100.0 63450.899999999994 73062.7 77492.8 83079.7 88051.0 62002.4 59042.2 65706.9 54998.7 81297.7 True False 59924.552992077624 78666.37415639183 72506.99761578128 71764.10153952356 76989.24619407256 70542.66779825161 61787.7792898998 65898.09620063717 65999.97679207413 78950.42416420794 0.7590149594059348 0.9964021724921285 0.9183864226615798 0.9089767699064207 0.9751593738615469 0.8935058746680176 0.7826149123833486 0.8346769114701219 0.835967349013878 1.0 16.2686593965907 -7.010731248966708 24.644842631961875 0.8478982246644774 0.918312487153922 0.06031260974553143 0.0790610148892432 822.1042673018954 1888003.5416170636 0.027466795617786338 0.02270459613425497 9.755931695950658e-08 7.010731248966708 0.0704142624894446 DFTPVCTTELGR ddPTM_A459_Selumetinib_30min_R1 1 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 126.03 0.03869 3641400.0 385.53 488.13 448.86 343.96 310.42 400.91 292.98 315.49 270.62 352.53 False True 394.51209888920783 430.9795126745195 387.90727741149243 283.8938429288554 282.34256580910244 396.8772093971553 270.88028272044875 307.1221803440529 459.2223746972213 397.78065943298986 0.9917830078806719 1.0834601996206965 0.975178828363422 0.7136944348514264 0.7097946044223548 0.9977287733467928 0.6809790176992787 0.7720892734750737 1.154461293698423 1.0 8.635829322109203 -5.5535170208703475 11.025015971902128 0.8436066141702451 1.035580339916097 0.19213227879179573 0.14676503511778996 0.7465906372104809 265.07190433705256 0.039408799609084014 0.06848923565261188 2.7956511582670104e-06 5.5535170208703475 0.19197372574585192 DFTPVCTTELGR ddPTM_A459_Selumetinib_30min_R2 2 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 ; 141.89 0.013221 9733300.0 18730.1 17513.5 19778.0 19664.6 20682.7 16685.3 15694.3 17666.7 8795.5 19001.5 False True 17689.156024530985 18856.729135221765 18505.505012658203 16986.24755667288 18084.354320316004 18983.54862092708 16424.11604766547 17718.107172120366 10554.845766803357 18452.877323173972 0.9586123461795375 1.0218855739934183 1.0028520045173734 0.9205202667955077 0.9800289680355074 1.0287581870544744 0.8900571851219814 0.9601812693931018 0.5719891582191411 1.0 14.171558170156022 -8.047576432018609 24.99876074225033 0.779357876161464 0.9718724658564256 0.3351358862326983 0.10390135123444401 402.94504434398607 211722.72488663474 0.06382650155189408 0.024125559875645297 8.962384419667827e-09 8.047576432018609 0.1925145896949616 DFTVSAMHGDMDQK ddPTM_A459_Selumetinib_30min_R1 5 DFTVSAMHGDMDQK 14 0 P60842;P60842-2;J3KT12;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 ;;;; 333.88 1.3799999999999991e-124 69648600.0 20659.0 22539.699999999997 22055.699999999997 24866.3 24746.8 22000.5 25905.0 20865.8 7874.5 16285.899999999998 False True 21140.31450458367 19900.741445577743 19060.657083288002 20523.86750326143 22508.45630940241 21779.19494485575 23950.96499376484 20312.37120232951 13362.451369275246 18376.353903099687 1.1504085421982304 1.0829537540752807 1.0372382456169875 1.1168628777768317 1.2248597533597634 1.185174984096387 1.3033578434579907 1.1053537230202808 0.7271546597185035 1.0 14.165562925951845 -8.126336029417072 6.182492953980254 0.8679289647394048 1.1552643950555064 0.6089565934656789 0.09272100001747431 0.15575736860600195 7.038385206970675 0.0661904899165073 0.024464996015248746 7.475908384849711e-09 8.126336029417072 0.28733543031610154 DFTVSAMHGDMDQK ddPTM_A459_Selumetinib_30min_R2 2 DFTVSAMHGDMDQK 14 0 P60842;P60842-2;J3KT12;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 ; 167.03 0.00031196 24671000.0 137940.0 131203.0 188190.0 249250.0 235550.0 173697.0 148047.0 167414.0 167752.0 209030.0 False True 130273.84701757086 141265.84821586194 176082.06028577965 215301.7200197671 205958.1031562823 197622.18508562472 154931.47884956497 167901.14702312025 201307.08738250224 202994.76077483626 0.6417596519255582 0.6959088386155708 0.867421699031393 1.0606269797208305 1.0145981224842202 0.9735334268298143 0.7632289535857354 0.8271205935672291 0.9916861233960319 1.0 17.631082966863502 -5.294554266675072 3.171402686571299 0.9376105806879953 0.6560785238759141 0.6217306807025976 0.08554844441783631 0.18055079989781975 3.667497970555934 0.02577283767920304 0.0699277655924902 5.07511319681498e-06 5.294554266675072 -0.28153205681208116 DFVDDDDDDDLER ddPTM_A459_Selumetinib_30min_R2 1 DFVDDDDDDDLER 13 0 G3V4K3;Q9H9C1-2;Q9H9C1 G3V4K3 VIPAS39 Spermatogenesis-defective protein 39 homolog 0 234.3 1.8874e-12 6623100.0 38448.0 37154.0 38193.0 43737.0 43170.0 33717.0 32633.0 37482.0 29511.0 36378.0 False True 36311.2140795387 40003.59233106057 35735.70396139424 37779.94514946665 37746.598655303314 38361.210697548064 34150.499161062755 37591.06641452088 35414.02460623434 35327.67261860497 1.0278405393854266 1.132358555372059 1.0115499072694187 1.0694150604636834 1.0684711405365674 1.0858686082067435 0.9666784316575027 1.0640685793358466 1.0024443157793501 1.0 15.10851108739118 -7.241215388039187 24.99373525967885 1.0136368732892616 1.0667411871453276 0.3543885113382229 0.03781622612721644 951.8535874554258 1176345.412748527 0.013680827149744734 0.010585105657205574 5.738318001513351e-08 7.241215388039187 0.053104313856066065 DFVTIS(ph)PVQPEER ddPTM_A459_Selumetinib_30min_R1 1 DFVTISPVQPEER 13 0 Q9H611-2;Q9H611-4;Q9H611;Q9H611-3 Q9H611-2 PIF1 ATP-dependent DNA helicase PIF1 1 DFVT(0.068)IS(0.932)PVQPEER 91.712 0.019423 2824700.0 1085.0 1246.4 991.49 1183.2 1159.3 1054.0 1081.6 1153.2 507.1 955.36 True False 1110.2783889575142 1100.4709085643606 856.8511038647251 976.5763314147632 1054.441519691039 1043.39771695543 1000.0140411988441 1122.6133898784803 860.511662881387 1077.9897619944436 1.0299526285883567 1.020854693952124 0.7948601499511659 0.9059235679640869 0.9781554119216895 0.9679105996563334 0.9276656202640249 1.0413952242009017 0.7982558770217917 1.0 10.074127761092038 -5.045212934954087 24.93756159276816 0.9293088064086529 1.0276787449758529 0.21362220587995362 0.07565893914638423 551.0923214489634 303959.33349085803 0.01882923104533138 0.04982257458041384 9.011292048587539e-06 5.045212934954087 0.0983699385672 DFVTIS(ph)PVQPEER ddPTM_A459_Selumetinib_30min_R2 2 DFVTISPVQPEER 13 0 Q9H611-2;Q9H611-4;Q9H611;Q9H611-3 Q9H611-2 PIF1 ATP-dependent DNA helicase PIF1 1 DFVT(0.018)IS(0.982)PVQPEER;DFVT(0.311)IS(0.689)PVQPEER 115.26 0.0044413000000000005 1185700.0 21782.0 21088.7 26807.0 22535.9 24846.0 20846.6 18574.0 20933.7 18098.8 22831.0 True False 20571.443640254678 22706.13547914187 25082.266805254756 19466.47154340411 21724.623353941784 23718.02992340675 19437.727803682763 20994.613601239405 21719.06572272419 22171.80970793805 0.927819781571082 1.02409933055724 1.1312683599424314 0.8779829792799745 0.9798308591005018 1.0697381150134586 0.8766865700062174 0.946905727488849 0.9795801970530278 1.0 14.436438910246915 -5.772734281262967 24.999987133083877 0.9610556313093066 1.0273662020656946 0.15819006229213262 0.06997105835206908 400.0255318759425 885411.6833452553 0.01998393357059442 0.029935350216464384 1.6875852417399789e-06 5.772734281262967 0.06631057075638802 DFYLAT(ph)SPPDSFLDDHHLTR ddPTM_A459_Selumetinib_30min_R2 2 DFYLATSPPDSFLDDHHLTR 20 0 Q13131;Q13131-2 Q13131 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 DFY(0.002)LAT(0.499)S(0.499)PPDSFLDDHHLTR;DFY(0.004)LAT(0.498)S(0.498)PPDSFLDDHHLTR 81.807 0.002782 2980600.0 10667.3 9805.7 14322.7 11913.9 13892.400000000001 15967.9 16073.2 17075.4 16120.0 11961.9 True False 10074.454170585288 10557.765659705023 13401.193075376672 10291.206267376154 12147.112512368225 18167.333282835876 16820.63564844159 17125.086587015358 19344.450430432626 11616.52886625133 0.8672516796178141 0.9088571793918356 1.1536314530505063 0.8859106180396502 1.0456748872426394 1.5639209863814076 1.4479915508417818 1.4741999769627954 1.6652522154559157 1.0 13.503891421135336 -6.683084151225718 5.4570840992842005 1.4603032137763206 0.9665938583226046 0.6191599661566166 0.17946184642969523 0.12597163352970356 6.4292733213941995 0.05700753222408464 0.056478457877471036 2.07451151004341e-07 6.683084151225718 -0.49370935545371597 DFYLAT(ph)SPPDSFLDDHHLTRPHPER ddPTM_A459_Selumetinib_30min_R1 1 DFYLATSPPDSFLDDHHLTRPHPER 25 1 Q13131;Q13131-2 Q13131 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 DFY(0.001)LAT(0.855)S(0.143)PPDS(0.001)FLDDHHLTRPHPER 81.807 5.7553e-05 3825800.0 325.63 394.07 519.75 476.15 640.36 424.59 354.34 343.93 180.96 195.01 True False 333.216545434318 347.9321012018273 449.1708047823893 392.99934094247715 582.4395510647405 420.319010096875 327.6118485192292 334.8078591579133 307.0759032045273 220.0414330582571 1.5143354631129728 1.581211758013367 2.041301033807888 1.7860242749756523 2.6469539984796255 1.910181206580278 1.488864365069338 1.5215673453156942 1.3955367356802635 1.0 7.781631393704581 -8.019200994408934 1.0944369946566568 1.0872046335179542 1.912747184804904 0.46280215044635353 0.30845980196070516 0.4833016931884415 1.0680089021974206 0.3073595592415745 0.10924470326689638 9.567511779318582e-09 8.019200994408934 0.8255425512869499 DGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVS(ph)SPVQEK ddPTM_A459_Selumetinib_30min_R1 1 DGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEK 41 1 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 DGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVS(0.91)S(0.089)PVQEK 87.45 5.7322e-12 7368000.0 1980.9 2642.8 2473.2 2203.8 2377.5 2181.7 2160.0 2067.1 1258.3 2045.5 True False 2027.0511158395743 2333.3797473956115 2137.3530243151613 1818.9477004495052 2162.4555447817165 2159.754078825106 1997.0694609740244 2012.273793112908 2135.2431974041574 2308.059849857264 0.8782489396732637 1.010970208393822 0.926038821934076 0.78808515323465 0.9369148485969495 0.9357443997644472 0.8652589581234335 0.8718464528713811 0.9251247091951302 1.0 11.172464919378916 DGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVS(ph)SPVQEK ddPTM_A459_Selumetinib_30min_R2 1 DGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEK 41 1 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 DGAEQQGPEATVEEAEAAAFGS(0.006)EKPQS(0.003)MFEPPQVS(0.675)S(0.316)PVQEK 50.303 0.0012354 3487000.0 5076.3 5201.6 6738.6 6588.7 7621.4 5801.0 5847.9 6860.1 4685.1 5148.2 True False 4794.179568038966 5600.545994219858 6305.045812432935 5691.307693858538 6663.931595819519 6600.035093765052 6119.83893739402 6880.061755249312 5622.250912631511 4999.558089370008 0.9589206650548345 1.1202082052267104 1.261120623008389 1.138362149638649 1.3329041240641406 1.320123694091675 1.2240759739157623 1.3761339766963816 1.12454957260832 1.0 12.287584865459502 -4.735136905316128 1.5302504199097453 1.2432033976589485 0.8219274558159054 0.3463749249021939 0.10827100075568209 1.206814470081149 2.4550191288929093 0.0288367446030757 0.7993483512156482 1.8401918150611355e-05 4.735136905316128 -0.42127594184304307 DGAGLGLS(ph)GGSPGASTPVLLTR ddPTM_A459_Selumetinib_30min_R1 2 DGAGLGLSGGSPGASTPVLLTR 22 0 Q8N612;Q8N612-2 Q8N612 FAM160A2 FTS and Hook-interacting protein 1 DGAGLGLS(0.9)GGS(0.099)PGAS(0.001)TPVLLTR;DGAGLGLS(0.977)GGS(0.007)PGAS(0.014)T(0.002)PVLLTR 210.71 1.5475999999999998e-23 6299900.0 3120.9 3679.2000000000003 3434.1000000000004 3939.1 3320.8 2689.0 3150.8 2978.8 1701.35 2614.7 True False 3193.610897785718 3248.437553586325 2967.768082161045 3251.2101310648172 3020.4342263348594 2661.951101416653 2913.1326192763677 2899.7925474939443 2887.0666883124577 2950.322214334777 1.0824617332537003 1.101045010542608 1.0059132076291544 1.1019847646701473 1.0237641880806876 0.902257756282683 0.9873947344199505 0.9828731700573844 0.9785597906171134 1.0 11.526656809183239 -6.525998060482824 24.981840296417896 0.969419221841559 1.0691825874589522 0.6554641978294444 0.03507715951021325 57.7779888989936 462722.6747477523 0.01129520524698034 0.011352231820170903 2.978529731225356e-07 6.525998060482824 0.09976336561739318 DGAGLGLS(ph)GGSPGASTPVLLTR ddPTM_A459_Selumetinib_30min_R2 2 DGAGLGLSGGSPGASTPVLLTR 22 0 Q8N612;Q8N612-2 Q8N612 FAM160A2 FTS and Hook-interacting protein 1 DGAGLGLS(0.978)GGS(0.022)PGASTPVLLTR;DGAGLGLS(0.665)GGS(0.231)PGAS(0.088)T(0.016)PVLLTR 194.7 4.6715e-22 5649700.0 33453.0 32267.0 42375.0 43631.0 44397.0 33726.0 24593.4 27438.3 20719.7 31249.0 True False 31593.81618296942 34741.77514524228 39648.63863441155 37688.38253232686 38819.45194578417 38371.4503658542 25737.04183089759 27518.140910344915 24864.218956788758 30346.76017534736 1.0410935467383147 1.1448264969472846 1.3065196549917282 1.2419244200882957 1.279195924753764 1.2644331765282086 0.848098501526547 0.906790074174036 0.819336852208282 1.0 14.889254881913322 -7.2623030169830125 24.99968670575853 0.8857888499342021 1.218474831220492 0.7766448372823511 0.08385158130182802 36.73107159666493 1063227.9072738453 0.03524369299435494 0.02534360316502296 5.466344307273076e-08 7.2623030169830125 0.3326859812862899 DGAPVAT(ph)NAFHSPR ddPTM_A459_Selumetinib_30min_R1 1 DGAPVATNAFHSPR 14 0 Q96S52-2;Q96S52 Q96S52-2 PIGS GPI transamidase component PIG-S 1 DGAPVAT(0.757)NAFHS(0.243)PR 93.716 0.032934 4124400.0 1001.9 1230.3 1345.1 1322.9 1163.1 980.06 1206.9 890.32 626.86 848.49 True False 1025.242320641966 1086.2559040490469 1162.4428081054195 1091.8803489085444 1057.897810361983 970.2014862232822 1115.862561319236 866.7058214330639 1063.7356359570624 957.40195649249 1.0708588108572643 1.1345870944619985 1.21416381094949 1.140461789851282 1.104967253500992 1.0133690239966548 1.1655110518128433 0.9052684878651202 1.1110648236547724 1.0 9.902980944045407 -6.555987580513271 3.378660805491661 1.0409407947690799 1.1440093760363998 0.3051494207639698 0.07201022113670151 0.2999178272102983 7.153498422589543 0.02396660990929566 0.02490058820981003 2.7797927601477535e-07 6.555987580513271 0.10306858126731999 DGASSS(ph)PESASR ddPTM_A459_Selumetinib_30min_R1 1 DGASSSPESASR 12 0 A0A075B6E4;A0A0A6YYI5;G5E9M7;Q14135-2;Q14135;Q14135-4;G5E9M9;Q14135-5;Q14135-6 A0A075B6E4 VGLL4 Transcription cofactor vestigial-like protein 4 1 DGASS(0.044)S(0.956)PESASR 190.34 0.00013561 1794500.0 780.37 938.3 1054.5 1069.8 1190.9 877.87 978.67 959.42 413.28 920.35 True False 798.5511026643092 828.4433997961646 911.3046919538812 882.9795126331245 1083.1833052704721 869.0394248421857 904.8481339682626 933.9730649646306 701.3059752230718 1038.485887468165 0.7689571060143934 0.7977416061145662 0.8775320906629244 0.8502566315906652 1.043040948694334 0.8368331580902936 0.8713148102323162 0.8993603824907652 0.6753158455844404 1.0 10.020265895434889 -5.17550975845882 2.4974780975148185 0.8819767043642033 0.7692889630607821 0.15561387147646621 0.09278299917087103 0.5983926351079143 6.899107433313195 0.02473267883020837 0.09714132562154991 6.675599009372209e-06 5.17550975845882 -0.11268774130342119 DGASSS(ph)PESASR ddPTM_A459_Selumetinib_30min_R2 2 DGASSSPESASR 12 0 A0A075B6E4;A0A0A6YYI5;G5E9M7;Q14135-2;Q14135;Q14135-4;G5E9M9;Q14135-5;Q14135-6 A0A075B6E4 VGLL4 Transcription cofactor vestigial-like protein 4 1 DGASS(0.042)S(0.957)PESASR;DGASS(0.072)S(0.928)PESASR 203.88 4.0892e-05 50965000.0 31890.0 21872.0 27336.0 32554.0 30465.0 25601.0 29197.0 32972.0 23974.4 33899.0 True False 30117.68146578467 23549.51207043541 25577.231521186397 28120.089041217674 26637.714339444436 29127.305367260662 30554.718352757947 33067.94306119155 28769.949900704964 32920.24778982048 0.9148680064035722 0.7153503892433437 0.7769452916783732 0.8541882558342376 0.8091589865760757 0.884783904216764 0.928143632084264 1.0044864568551863 0.8739287165876417 1.0 15.006687574476661 -7.008561689347586 1.6014283668435811 0.9570417046128672 0.8047341331217525 0.5474342920887203 0.058939429300301174 0.2824198306886117 1.4630867759851502 0.028132228022272436 0.020946646850587405 9.804790323132135e-08 7.008561689347586 -0.15230757149111473 DGDGVPGGGPLS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 3 DGDGVPGGGPLSPAR 15 0 M0QZR4;Q92888-2;Q92888;Q92888-3 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 1 DGDGVPGGGPLS(1)PAR;DGDGVPGGGPLS(1)PAR;DGDGVPGGGPLS(1)PAR 144.4 0.00037347 92122700.0 151989.0 125947.0 118535.0 151431.0 155603.0 103053.0 108888.0 107769.0 88201.0 127114.0 True False 143542.059840174 135606.7299165656 110908.58715115007 130805.83656695469 136054.7600315303 117247.61532800707 113951.50775747879 108082.58994788169 105843.66454184779 123443.88853816461 1.1628122018839009 1.0985293117580353 0.8984534468618991 1.059638011374812 1.1021587349742863 0.9498049414715103 0.9231036797925309 0.8755604771350528 0.857423285958175 1.0 16.913495887718362 -6.921459258622406 4.433371004976907 0.9071629160948141 1.0563566594179574 0.4940778703484865 0.07262070657448948 0.19719599705207752 7.297477284537566 0.027824769282938762 0.024231772431069606 1.1982315246026544e-07 6.921459258622406 0.14919374332314328 DGDKS(ph)PMSSLQISNEK ddPTM_A459_Selumetinib_30min_R1 3 DGDKSPMSSLQISNEK 16 1 Q9UER7-3;Q9UER7;Q9UER7-2;Q9UER7-5;Q9UER7-4 Q9UER7-3 DAXX Death domain-associated protein 6 1 DGDKS(0.715)PMS(0.098)S(0.187)LQISNEK;DGDKS(0.656)PMS(0.129)S(0.216)LQISNEK;DGDKS(0.989)PMS(0.009)S(0.002)LQISNEK 168.42 6.2093e-05 78154000.0 10255.2 11041.9 9757.5 9388.599999999999 8857.7 9432.5 11247.9 10796.800000000001 6277.2 10803.0 True False 10494.12620685446 9749.109214759957 8432.485094110943 7749.057255849085 8056.522598953953 9337.617614024755 10399.461847263752 10510.433791050966 10651.949931451472 12189.670280131033 0.8609032045731144 0.7997844888922754 0.6917730258755037 0.6357068794945113 0.6609303134380883 0.7660270868232525 0.8531372554198375 0.8622410245322881 0.873850537927509 1.0 13.573371482402306 -7.913088211140135 0.9223853729732825 0.9715663811717282 0.7280324469814099 0.6069830617496881 0.06724580478343423 0.4271076838589283 0.6760345700120559 0.06987156783680247 0.027574686726005024 1.2215515211696791e-08 7.913088211140135 -0.24353393419031832 DGDKS(ph)PMSSLQISNEK ddPTM_A459_Selumetinib_30min_R2 2 DGDKSPMSSLQISNEK 16 1 Q9UER7-3;Q9UER7;Q9UER7-2;Q9UER7-5;Q9UER7-4 Q9UER7-3 DAXX Death domain-associated protein 6 1 DGDKS(0.997)PMS(0.002)SLQISNEK;DGDKS(0.998)PMS(0.001)S(0.001)LQISNEK 74.029 0.018224 123418000.0 162249.0 133174.0 145251.0 159437.0 150615.0 125648.0 169265.0 174709.0 114465.0 134387.0 True False 153231.85011420812 143388.01757809846 135905.7087973315 137721.40555583383 131693.39718481593 142954.87148101884 177136.15789223445 175217.37426536815 137361.19841932235 130506.89813064145 1.1741283587999944 1.0987006789063565 1.0413680099981049 1.0552806597086573 1.0090914662073016 1.0953817271629318 1.357293449078191 1.3425909034323238 1.052520597660819 1.0 16.993766538977965 -7.030028791997392 23.83085815944377 1.2180344067604079 1.071776488776122 0.16666056902173731 0.11232463781177826 520.8088399288808 413312.278843451 0.04231638329630008 0.03284002210073727 9.331924317983318e-08 7.030028791997392 -0.14625791798428578 DGDSVMVLPTIPEEEAK ddPTM_A459_Selumetinib_30min_R2 1 DGDSVMVLPTIPEEEAK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 112.15 0.027035000000000003 1564500.0 24064.0 20013.0 21151.0 23470.0 20303.0 16240.0 16256.0 20331.0 13762.0 21300.0 False True 22726.61921582447 21547.932748062532 19790.167687467583 20273.345511991738 17752.355628877078 18476.912587958006 17011.936210652904 20390.159844021757 16514.784542407804 20685.013655953757 1.0986997443573396 1.0417171149345799 0.9567394064432435 0.9800982416154447 0.8582230557903173 0.8932511670177121 0.8224280870008692 0.985745534577052 0.7983936978283968 1.0 14.336298289569696 -5.2351561868105225 0.9457701865245105 0.8901597847717584 1.1359209600612343 0.5396976830951308 0.06282096242084075 0.8238625410622297 0.9326139068998106 0.02145390369753375 0.17940245362222026 5.8189391163791806e-06 5.2351561868105225 0.24576117528947594 DGDSYDPYDFS(ph)DT(ph)EEEMPQVHTPK ddPTM_A459_Selumetinib_30min_R1 1 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 2 DGDS(0.001)YDPY(0.012)DFS(0.732)DT(0.81)EEEMPQVHT(0.445)PK 75.91199999999998 0.00040617 4737200.0 899.89 1220.8 1122.2 1362.5 996.6 981.6 917.78 745.4 427.91 963.08 True False 920.8556861188731 1077.868168465478 969.811403803362 1124.5649522926076 906.4577059640204 971.7259952214895 848.5511156910824 725.629570599566 726.1320166901487 1086.7006991936112 0.8473866693949826 0.9918721587878913 0.892436532453704 1.0348433134598087 0.8341374093498417 0.8941983712190128 0.7808508049371384 0.6677363612060074 0.6681987204287038 1.0 10.085738930411726 -7.1029736660666964 1.786157669699227 0.7478167352752066 0.9322963805795049 0.27965791687799124 0.10416030168784203 0.37804069231776494 2.3896080879509336 0.0488500997934124 0.034406109304956106 7.889079524873419e-08 7.1029736660666964 0.18447964530429828 DGDSYDPYDFS(ph)DTEEEMPQVHT(ph)PK ddPTM_A459_Selumetinib_30min_R1 5 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 2 DGDS(0.001)YDPY(0.005)DFS(0.934)DT(0.113)EEEMPQVHT(0.947)PK;DGDSYDPY(0.009)DFS(0.812)DT(0.38)EEEMPQVHT(0.798)PK;DGDSYDPY(0.001)DFS(0.957)DT(0.045)EEEMPQVHT(0.996)PK;DGDSYDPY(0.001)DFS(0.933)DT(0.068)EEEMPQVHT(0.998)PK;DGDS(0.001)YDPY(0.001)DFS(0.924)DT(0.082)EEEMPQVHT(0.992)PK 87.749 0.00026707 72249000.0 9070.84 10560.68 11397.16 12133.2 10054.57 8730.18 9676.3 10133.12 5789.62 8567.67 True False 9282.172923217859 9324.230676073068 9849.488272118624 10014.364388371872 9145.135918778516 8642.362315569226 8946.408900566172 9864.356740587436 9824.562282885694 9667.413900672977 0.9601505654549145 0.9645010311831153 1.0188338239488197 1.0358886555663809 0.9459754193561422 0.8939683771031678 0.9254190409643458 1.0203718224892337 1.016255472645252 1.0 13.238914295185555 -7.790291294743862 24.986154019957198 1.0137352849726533 0.9651299132158541 0.2461347628927052 0.038939656935689695 371.07433035377 321350.31738122547 0.02465790353830118 0.011848500065154732 1.620722663884527e-08 7.790291294743862 -0.04860537175679924 DGDSYDPYDFS(ph)DTEEEMPQVHT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 2 DGDS(0.001)YDPY(0.001)DFS(0.719)DT(0.281)EEEMPQVHT(0.999)PK;DGDS(0.008)Y(0.001)DPY(0.039)DFS(0.898)DT(0.104)EEEMPQVHT(0.95)PK 103.85 4.7067e-06 3741400.0 23751.0 21151.3 22835.6 21422.5 23962.4 16040.4 17822.4 19481.6 15648.9 22555.1 True False 22431.0145027862 22773.53669785115 21366.38235752137 18504.718544126248 20952.029085426002 18249.819499746398 18651.176914415624 19538.28823064751 18779.117266798836 21903.87565781232 1.0240660079160864 1.03970352341407 0.9754612695630762 0.8448148096351288 0.9565443765634768 0.8331776433015564 0.8515012231528727 0.8920014218433033 0.8573422146916271 1.0 14.418898541504124 -5.570929026188536 4.203242813260034 0.8852387110339544 1.0282157392918456 0.5705409570745152 0.049911270352187946 0.131779276391652 4.940634255875621 0.013044276373659201 0.024417693602912793 2.6857833292099657e-06 5.570929026188536 0.14297702825789127 DGDSYDPYDFS(ph)DTEEEMPQVHTPK ddPTM_A459_Selumetinib_30min_R1 5 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 DGDSYDPYDFS(0.991)DT(0.009)EEEMPQVHTPK;DGDSYDPYDFS(0.5)DT(0.5)EEEMPQVHTPK;DGDSYDPYDFS(0.851)DT(0.149)EEEMPQVHTPK;DGDSYDPYDFS(0.751)DT(0.249)EEEMPQVHTPK;DGDSYDPYDFS(0.993)DT(0.007)EEEMPQVHTPK 171.29 3.1727e-16 507695300.0 24052.800000000003 27846.5 28931.300000000003 31255.999999999996 26177.0 23753.3 25606.200000000004 23516.6 12780.8 20984.5 True False 24613.183441398414 24586.21883451337 25002.588368255394 25797.726347785512 23809.294971924708 23514.363368270802 23674.703718330107 22892.863375317604 21688.084127301176 23678.06498133941 1.0394930270187184 1.0383542259002023 1.0559388357097523 1.0895200417819868 1.0055422599223678 0.9930863601735354 0.9998580431715197 0.9668384385869108 0.9159567787483256 1.0 14.531263565419529 -6.86885004906501 1.2237226307147506 0.9625155426167087 1.0538479252450608 0.6647289272410257 0.02673655722411868 0.2801126086382211 0.8763166289742392 0.014589295939526141 0.011892062463927051 1.3525394803640632e-07 6.86885004906501 0.09133238262835208 DGDSYDPYDFS(ph)DTEEEMPQVHTPK ddPTM_A459_Selumetinib_30min_R2 10 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 DGDSYDPYDFS(0.982)DT(0.018)EEEMPQVHTPK;DGDSYDPYDFS(0.965)DT(0.035)EEEMPQVHTPK;DGDSYDPY(0.023)DFS(0.487)DT(0.487)EEEMPQVHT(0.003)PK;DGDSYDPYDFS(0.774)DT(0.226)EEEMPQVHTPK;DGDSYDPYDFS(0.988)DT(0.012)EEEMPQVHTPK;DGDSY(0.001)DPY(0.009)DFS(0.567)DT(0.422)EEEMPQVHTPK;DGDSYDPYDFS(0.99)DT(0.01)EEEMPQVHTPK;DGDS(0.003)YDPY(0.002)DFS(0.495)DT(0.495)EEEMPQVHT(0.003)PK;DGDSYDPYDFS(0.988)DT(0.012)EEEMPQVHTPK;DGDSYDPY(0.004)DFS(0.654)DT(0.342)EEEMPQVHTPK 131.5 7.302500000000001e-08 170101300.0 972619.5 878636.7 972210.4 1066126.1 1060724.7 809080.3 856676.1 851170.3 733531.6 918788.0 True False 918565.2018943469 946025.3096277204 909659.4413266496 920917.886009895 927466.9801868673 920523.7672252976 896513.2361214891 853647.0646541717 880258.4165853579 892260.2031420869 1.0294813089944246 1.0602572055733295 1.01950018405314 1.0321180780750843 1.039457970803584 1.031676369722286 1.0047665837436492 0.9567243519861814 0.9865490060920964 1.0 19.76710496826037 -7.42961327465297 3.1036947751513746 0.9787086122165435 1.0359756602195356 0.7467867616697212 0.014207478989015247 0.11839751638900768 2.1880203291485025 0.006598571358843728 0.00403048732770904 3.718662166817308e-08 7.42961327465297 0.057267048002992094 DGDSYDPYDFSDT(ph)EEEMPQVHT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 2 DGDSYDPY(0.001)DFS(0.169)DT(0.843)EEEMPQVHT(0.986)PK 83.022 0.00063393 5622200.0 1579.0 1657.7 1988.7 2438.4 1532.7 1746.7 1689.0 1647.3 1007.8 1470.5 True False 1615.787627800843 1463.6157133561771 1718.645463147162 2012.5792144369145 1394.067555620164 1729.1297838767077 1561.5973701782987 1603.6082528154875 1710.1629932002784 1659.2529988829658 0.973804253413202 0.8820931553786585 1.0357947005695816 1.2129429422708973 0.8401778128824666 1.0421133998496819 0.9411448231400453 0.966463977401313 1.0306824784114212 1.0 10.696318166377933 -6.386585485760567 0.004231745134317504 1.3895482575859375 0.5920145513821099 0.0023837762005045615 0.09658092509180909 388093.53954875685 503.8897159150866 46761.74905559137 48200.66567620622 4.105958109640349e-07 6.386585485760567 -0.7975337062038276 DGDSYDPYDFSDT(ph)EEEMPQVHTPK ddPTM_A459_Selumetinib_30min_R1 7 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 DGDSYDPYDFS(0.042)DT(0.958)EEEMPQVHTPK;DGDSYDPYDFS(0.209)DT(0.791)EEEMPQVHTPK;DGDSYDPYDFS(0.134)DT(0.855)EEEMPQVHT(0.01)PK;DGDSYDPYDFS(0.413)DT(0.587)EEEMPQVHTPK;DGDSYDPYDFS(0.43)DT(0.57)EEEMPQVHTPK;DGDSYDPY(0.006)DFS(0.389)DT(0.604)EEEMPQVHTPK;DGDSYDPY(0.003)DFS(0.199)DT(0.799)EEEMPQVHTPK 133.94 1.3097e-07 232304100.0 27490.07 31556.410000000003 32827.29 34826.93 30097.06 26462.66 29137.75 26959.309999999998 15922.89 24239.75 True False 28130.535144635272 27861.77084702301 28369.5243253966 28745.060457943473 27374.786237067518 26196.469666572844 26939.866058562904 26244.261522619512 27019.981368127414 27351.158027659552 1.0284952145787596 1.018668782464241 1.0372330230664164 1.0509631961057846 1.0008638833275019 0.9577828346456483 0.9849625391114805 0.9595301777014098 0.9878916768643862 1.0 14.739314296493916 -6.498007059881673 5.058312543832554 0.9760404066974089 1.0326061896587346 0.7764735662778717 0.01407915700084842 0.08332106507443833 5.841759347862702 0.004428214270035574 0.004807719687105836 3.176822427873572e-07 6.498007059881673 0.05656578296132575 DGDSYDPYDFSDT(ph)EEEMPQVHTPK ddPTM_A459_Selumetinib_30min_R2 6 DGDSYDPYDFSDTEEEMPQVHTPK 24 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 DGDSYDPYDFS(0.293)DT(0.706)EEEMPQVHTPK;DGDSYDPY(0.001)DFS(0.263)DT(0.736)EEEMPQVHTPK;DGDSYDPY(0.001)DFS(0.053)DT(0.946)EEEMPQVHTPK;DGDSYDPY(0.001)DFS(0.299)DT(0.7)EEEMPQVHTPK;DGDSYDPY(0.01)DFS(0.114)DT(0.875)EEEMPQVHT(0.001)PK;DGDSYDPY(0.002)DFS(0.341)DT(0.655)EEEMPQVHT(0.001)PK 89.663 0.00010011 81175000.0 478175.0 427090.0 499330.0 547815.0 539409.0 382252.0 435635.0 448938.0 354036.0 440958.0 True False 451599.9477861901 459846.42968920275 467203.6514293977 473201.65196641575 471643.6190423563 434903.7432618302 455892.8906943758 450244.3352543129 424853.09259234887 428226.39679352427 1.0545822283905952 1.0738395230477222 1.0910202054981373 1.1050268164448933 1.1013884771558498 1.0155930286369654 1.0646071659944665 1.0514165839043428 0.9921226149848911 1.0 18.708014203717788 -7.82517189396804 0.7948322740558647 0.9952513004543195 1.0824682037374909 0.6004998738453774 0.024433626520629272 0.4553512429010636 0.5461911229788746 0.02364769828075478 0.010451725791186615 1.4956435624742142e-08 7.82517189396804 0.08721690328317133 DGEEAGAYDGPR ddPTM_A459_Selumetinib_30min_R1 2 DGEEAGAYDGPR 12 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 ; 136.52 0.019401 27578000.0 5085.6 5413.799999999999 6395.2 6401.6 5749.1 5202.2 4858.1 4960.3 3317.6000000000004 4089.6 False True 5204.0845851450085 4779.949779192659 5526.766966319065 5283.680732914762 5229.094920086042 5149.870591219675 4491.64960572125 4828.73673067484 5629.7248920830025 4614.53999607737 1.1277580407947023 1.0358453460704418 1.1976853534733995 1.1450070293910555 1.1331779385444876 1.1160095254559212 0.9733688752377085 1.0464177869905884 1.219996987103503 1.0 12.1719711235505 -7.0282322295583075 24.325261616210287 1.0610819303298853 1.127307337248289 0.17270849650179654 0.07110550035660412 985.1454484269366 848811.3849890332 0.027331282458255203 0.021221847322205303 9.370607999865687e-08 7.0282322295583075 0.06622540691840362 DGETLEGS(ph)DAEESLDK ddPTM_A459_Selumetinib_30min_R2 2 DGETLEGSDAEESLDK 16 0 Q9P2D1;Q9P2D1-4;Q9P2D1-3 Q9P2D1 CHD7 Chromodomain-helicase-DNA-binding protein 7 1 DGET(0.005)LEGS(0.995)DAEESLDK;DGETLEGS(0.999)DAEESLDK 199.65 8.0345e-07 10634000.0 43590.0 26399.0 33451.0 37349.0 35031.0 34783.0 52714.0 56767.0 44511.0 30705.0 True False 41167.442304595585 28423.71841383614 31298.799078694996 32262.001769381295 30630.092598886524 39574.04252136351 55165.30545080941 56932.18257171725 53414.44374125231 29818.466868829106 1.380602245101682 0.9532253465233999 1.0496448129401772 1.081947033403872 1.027218895378751 1.327165568084 1.8500382898114978 1.9092927487573685 1.7913209279411137 1.0 14.863918462201061 -7.052582337680781 3.84014563223517 1.7097733318625818 1.0902380214819154 0.47662504682852225 0.2612006825575436 0.17049889409869448 5.109435291563372 0.097753674551478 0.07707758433939062 8.859672376357156e-08 7.052582337680781 -0.6195353103806664 DGETPDPEDPSR ddPTM_A459_Selumetinib_30min_R2 1 DGETPDPEDPSR 12 0 P09960-3;P09960-2;P09960-4;P09960 P09960-3 LTA4H Leukotriene A-4 hydrolase 0 125.68 0.039365 3042000.0 31738.0 30240.0 30461.0 31725.0 33758.0 27499.0 28369.0 26654.0 21531.0 31866.0 False True 29974.12901728046 32559.31076307455 28501.172423429136 27404.000271322457 29517.01823965092 31286.73763893211 29688.214712107078 26731.558727192758 25837.80162640479 30945.94578218886 0.9685963139808854 1.0521349385228442 0.920998589735563 0.8855441182571646 0.9538250485994074 1.0110124880054367 0.9593571617124179 0.863814566061131 0.8349333320837105 1.0 14.917462794383114 -7.733515831427809 12.088297446528005 0.8870417650567792 0.9645555891410981 0.19702084546315968 0.058430461461741114 1.112472861995646 479.6963220425173 0.028431318037205586 0.016283930844175315 1.8470734619261697e-08 7.733515831427809 0.07751382408431884 DGFIDKEDLHDMLASLGK ddPTM_A459_Selumetinib_30min_R1 1 DGFIDKEDLHDMLASLGK 18 1 J3QRS3;P19105;O14950;J3KTJ1;P24844 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 79.013 0.0099179 6788500.0 11947.0 12695.0 8512.0 8017.9 10643.0 9659.7 10669.0 10928.0 7772.2 11274.0 False True 12225.34185518471 11208.663498254613 7356.117153069159 6617.724279623417 9680.34252917426 9562.532188305857 9864.228740338816 10638.153940853303 13188.855740971627 12721.127718059544 0.9610265792575141 0.8811061209881761 0.5782598301112919 0.5202152219750587 0.7609657527006483 0.7517047545030471 0.7754209342883231 0.8362587167292449 1.0367678112568646 1.0 13.634938949632081 -8.055854546957633 2.013952146069391 1.0251695167119563 0.7347465950106841 0.4349333421551238 0.12138534199884973 0.3519222664196053 2.567139402732702 0.11681264619023472 0.03767849291880426 8.793169666059176e-09 8.055854546957633 -0.29042292170127226 DGFPS(ph)GTPALNAK ddPTM_A459_Selumetinib_30min_R2 2 DGFPSGTPALNAK 13 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 DGFPS(0.917)GT(0.083)PALNAK;DGFPS(0.998)GT(0.002)PALNAK 130.66 0.0016026 11690300.0 69376.0 61783.0 61659.0 68738.0 75387.0 87199.0 88165.0 87111.0 71967.0 69448.0 True False 65520.35965413229 66521.5574363436 57691.92706924321 59375.76582033613 65916.21109166901 99209.87073629003 92264.84719563331 87364.47858799757 86362.41092598901 67442.8557924262 0.9714944434706189 0.9863395708076458 0.8554193975238218 0.8803862932951899 0.9773638781629317 1.4710212011430164 1.3680447856419895 1.295385219998477 1.2805271946341197 1.0 16.041378006433547 -6.660004643700863 6.552943536587607 1.3056697085905584 0.9245921678680825 0.6855490764884495 0.11789991213114348 0.11460247555705785 6.419337429303338 0.038051156003621245 0.03793561083408212 2.1877382313976077e-07 6.660004643700863 -0.3810775407224759 DGGAWGTEQR ddPTM_A459_Selumetinib_30min_R1 1 DGGAWGTEQR 10 0 P09382 P09382 LGALS1 Galectin-1 0 174.86 4.9949e-07 0.0 2660.8 2983.0 3102.7 2945.7 2854.7 2550.6 2686.4 2394.6 1503.3 2033.2 False True 2722.7914629844736 2633.7489732409244 2681.3703819111493 2431.2887926373105 2596.4928890382216 2524.943279759507 2483.7626851669525 2331.0874292429844 2550.9903033121445 2294.181025045117 1.186825029612006 1.1480127088877519 1.1687701853686188 1.059763273296839 1.1317733259463076 1.1005858963155932 1.082635876616627 1.016086962534764 1.1119394134392586 1.0 11.163763518051951 -1.5228787452803376 0.125987130872753 0.9742529619785968 1.6606727765007685 0.6629290744383736 0.03419176152771788 51.116942240489806 0.4402596021278407 0.19592587763790342 6.19856015661217 0.029999999999999995 1.5228787452803376 0.6864198145221717 DGGAWGTEQR ddPTM_A459_Selumetinib_30min_R2 2 DGGAWGTEQR 10 0 P09382 P09382 LGALS1 Galectin-1 0 ; 140.11 0.020135 84375000.0 214753.0 189609.0 194217.0 223532.0 222769.0 163929.0 149062.0 171484.0 172323.0 193907.0 False True 202817.88798437305 204151.40061097208 181721.2896674813 193086.5559857923 194782.76663987205 186508.73175069987 155993.67836074962 171982.99004929553 206792.4151069132 188308.40107910943 1.0770517237792705 1.0841332592761324 0.9650195563560605 1.0253740931328685 1.0343817138463338 0.9904429684597369 0.828394683757183 0.9133049246010245 1.0981582017683773 1.0 17.522737839364012 -7.0009569760744546 14.312151135796173 0.9465524420175279 1.03286756780186 0.200536060640779 0.0708165325324332 0.25789299767187746 3578.3138378775707 0.02622201519000862 0.022452194706754493 9.977989071220416e-08 7.0009569760744546 0.08631512578433209 DGGGLAPPPGS(ph)CSPSLSPSSNR ddPTM_A459_Selumetinib_30min_R2 1 DGGGLAPPPGSCSPSLSPSSNR 22 0 A8MUP8;P10276-3;P10276-2;P10276 A8MUP8 RARA Retinoic acid receptor alpha 1 DGGGLAPPPGS(0.91)CS(0.089)PS(0.001)LSPSSNR 159.41 4.1559e-09 3910200.0 53093.0 46823.0 50237.0 58738.0 60079.0 45042.0 49834.0 49396.0 42278.0 50257.0 True False 50142.30360811868 50414.1735403254 47004.80611390995 50737.78307129826 52531.3389069254 51246.12664943377 52151.37974419767 49539.73418205196 50734.78134601928 48805.949826632284 1.0273809604409578 1.032951386447878 0.9630958168190492 1.0395819208831751 1.0763306337347471 1.0499975275856621 1.0685455344983341 1.015034731585518 1.0395204176179043 1.0 15.574769413856874 -5.97093489369381 24.99910783371082 1.0453535156781655 1.0088261153425175 0.23108623202549095 0.027471411864992322 280.9910140629906 241680.5129439139 0.007722550020294396 0.011454253503533626 1.0692151562572354e-06 5.97093489369381 -0.03652740033564794 DGGQTES(ph)NEEGKENR ddPTM_A459_Selumetinib_30min_R1 2 DGGQTESNEEGKENR 15 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5;Q5VU81;Q5VU80;Q5VU79;Q5VU78;Q5VU77 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 DGGQTES(1)NEEGKENR;DGGQTES(1)NEEGKENR 254.89 5.7298e-28 52073500.0 6914.7 8370.4 8985.4 8196.5 7263.7 8207.5 7831.8 7234.9 4610.2 7374.200000000001 True False 7075.7990563359635 7390.389676706613 7765.232033269228 6765.135142360635 6606.699617510397 8124.940001813753 7241.041020581645 7043.0069497327595 7823.172684314279 8320.750400790721 0.8503799195398951 0.8881878821896044 0.933236986958688 0.8130438742301108 0.7940028602327216 0.9764672187548902 0.8702389414172944 0.8464389160217404 0.9402003794718854 1.0 13.02249792729303 -8.505048368951172 3.8915555628936613 0.9996779078459681 0.87334661098386 0.4013821711496951 0.05070566599371099 0.19450699971381885 7.727082110416642 0.04994190930466868 0.013111898284094262 3.125731223717241e-09 8.505048368951172 -0.1263312968621081 DGGQTESNEEGKENR ddPTM_A459_Selumetinib_30min_R1 2 DGGQTESNEEGKENR 15 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5;Q5VU81;Q5VU80;Q5VU79;Q5VU78;Q5VU77 F8W726 UBAP2L Ubiquitin-associated protein 2-like 0 ; 130.27 0.0022872 6023600.0 891.78 1315.0 1209.97 1473.23 1164.1 1065.86 1095.48 1135.82 752.69 890.27 False True 912.5567388981857 1161.0391886730847 1045.6627198894607 1215.9580364521396 1058.8073605385478 1055.1384161234494 1012.8470616239925 1105.6943639366773 1277.2599556974776 1004.5448264641528 0.9084280908700197 1.1557863403266617 1.0409318652011148 1.2104567207141264 1.054017036019578 1.0503646908793294 1.008264673652307 1.1006919102142565 1.271481293864447 1.0 9.972326228498932 -8.008188632934992 24.514556635325683 1.1525226323646929 1.0680450486372084 0.07918339093980842 0.09782111555543271 622.8617174955431 1864666.8000799757 0.05441964421427011 0.024147423787542966 9.813216198880387e-09 8.008188632934992 -0.08447758372748448 DGGQTESNEEGKENR ddPTM_A459_Selumetinib_30min_R2 3 DGGQTESNEEGKENR 15 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5;Q5VU81;Q5VU80;Q5VU79;Q5VU78;Q5VU77 F8W726 UBAP2L Ubiquitin-associated protein 2-like 0 ;; 141.06 0.0010905 8027100.0 20174.4 21215.1 17857.1 20306.2 22482.9 15823.5 19771.6 22599.999999999996 17116.6 21848.1 False True 19053.187612521986 22842.229952701808 16708.19362734042 17540.460529851152 19658.39710232382 18003.043493568563 20691.01857668215 22665.762258368602 20540.398277763237 21217.28858481894 0.8980029439838332 1.07658572212877 0.7874801514127118 0.8267060354922743 0.9265272998355447 0.8485082069558038 0.9751961705175967 1.0682685569251318 0.9680972286185512 1.0 14.37295268164703 -7.46378838303372 5.6826919144115635 1.015424016974748 0.896421385642957 0.3373848680874739 0.07596517802397952 0.25471933202426555 17.28688481670652 0.03408832055017528 0.02228924197726375 3.437253928234474e-08 7.46378838303372 -0.1190026313317909 DGGRS(ph)SPGGQDEGGFMAQGK ddPTM_A459_Selumetinib_30min_R1 2 DGGRSSPGGQDEGGFMAQGK 20 1 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30 A0A1B0GTU4 PXN Paxillin 1 DGGRS(0.5)S(0.5)PGGQDEGGFMAQGK;DGGRS(0.605)S(0.395)PGGQDEGGFMAQGK 111.53 0.00019201 35964000.0 3272.91 3330.3599999999997 9180.699999999999 9080.199999999999 5637.200000000001 4424.58 3541.0699999999997 3576.05 2516.05 2441.82 True False 3349.162435025749 2940.43990295764 7934.011365975334 7494.513526464105 5127.316255328496 4380.072742397209 3273.964238968186 3481.2015373525305 4269.5530849787265 2755.251382340975 1.2155560311089155 1.067212930843109 2.8795961837915027 2.720083392208103 1.8609250278180123 1.5897180092060128 1.1882633504702178 1.2634787372449328 1.5496056411923977 1.0 11.427968237401068 -6.91086972947534 2.8005183512948677 1.2784798895808642 1.9980493971233682 0.26677571239208353 0.5433146775038726 0.4206342670614587 6.676091672279504 0.237298013242043 0.2021052522041217 1.2278074677888184e-07 6.91086972947534 0.7195695075425039 DGGS(ph)GNSTIIVSR ddPTM_A459_Selumetinib_30min_R1 3 DGGSGNSTIIVSR 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 DGGS(0.868)GNS(0.066)T(0.066)IIVSR;DGGS(0.998)GNS(0.002)TIIVSR;DGGS(0.859)GNS(0.07)T(0.07)IIVSR 149.6 0.00051494 54175100.0 4827.1 5352.0 5756.700000000001 6004.6 5811.4 4949.0 5595.200000000001 5203.0 2544.55 4368.299999999999 True False 4939.5620380984465 4725.385351922702 4974.971759289618 4956.009330301795 5285.759896086002 4899.217553332472 5173.149559278638 5064.999538274136 4317.915503421089 4929.013855845262 1.0021400187870593 0.9586877801771486 1.009323955011783 1.005476850998201 1.0723767574355019 0.9939549160574067 1.0495303341750315 1.0275888212948743 0.8760201593469902 1.0 12.267083321206055 -8.234905309867292 24.88083800503939 0.938010048000025 1.0148863010841591 0.36812001922263604 0.0402871707835232 625.2454163340491 586290.686487338 0.026705634245474726 0.010088043679943298 5.8223014878790356e-09 8.234905309867292 0.07687625308413415 DGGS(ph)GNSTIIVSR ddPTM_A459_Selumetinib_30min_R2 2 DGGSGNSTIIVSR 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 DGGS(0.985)GNS(0.01)T(0.005)IIVSR;DGGS(1)GNSTIIVSR 119.96 0.0031273000000000004 72779000.0 108099.0 81888.0 105527.0 134468.0 139514.0 77138.0 84218.0 110510.0 68232.0 96915.0 True False 102091.29033458314 88168.54628857966 98737.50770911021 116153.22642976188 121987.00404901529 87763.05931095482 88134.30387480112 110831.56580408452 81880.30656136967 94116.81213458977 1.0847295825169858 0.9367991147266663 1.0490953260073526 1.2341389789494719 1.2961234160223185 0.9324907773698402 0.9364352858527178 1.1775958332034469 0.8699859749210211 1.0 16.522164834881032 DGGS(ph)PIKGY(ph)IVEMQEEGTT(ph)DWKR ddPTM_A459_Selumetinib_30min_R2 1 DGGSPIKGYIVEMQEEGTTDWKR 23 2 A0A0A0MTS7;Q8WZ42-5;Q8WZ42-11;Q8WZ42-4;Q8WZ42-7;Q8WZ42-2;Q8WZ42;Q8WZ42-8;Q8WZ42-13;Q8WZ42-12;A0A0A0MRA3;Q8WZ42-3;Q8WZ42-10;Q8WZ42-9 A0A0A0MTS7 TTN Titin 3 DGGS(1)PIKGY(1)IVEMQEEGT(0.374)T(0.626)DWKR 45.707 0.034549 7843100.0 35077.0 13774.0 30596.0 25497.0 16314.0 18312.0 32985.0 29183.0 23547.0 20655.0 True False 33127.560764356516 14830.421509609418 28627.486670406055 22024.264615221688 14264.489470989538 20834.311780214724 34518.86785853754 29267.91769849426 28257.05795815119 20058.636481865025 1.6515360251085403 0.7393534213064569 1.4271900633070502 1.0979941051892428 0.711139537519713 1.0386703901359888 1.7208980226420665 1.4591180075951489 1.4087227705481546 1.0 14.291935919312616 -7.232585744528474 24.848048169677867 1.4354445949814119 1.0896966821313543 0.16226978211590204 0.3115531869940417 993.7449002193159 855790.11999881 0.11528091494621663 0.08928094264459807 5.853481572404806e-08 7.232585744528474 -0.34574791285005757 DGHRIS(ph)LPSDFQHK ddPTM_A459_Selumetinib_30min_R2 1 DGHRISLPSDFQHK 14 1 Q5TCX8;Q5TCX8-2 Q5TCX8 MLK4 Mitogen-activated protein kinase kinase kinase MLK4 1 DGHRIS(1)LPSDFQHK 66.289 0.029791 8024800.0 29267.0 26517.0 31041.0 30332.0 33372.0 27984.0 25406.0 28797.0 22724.0 31555.0 True False 27640.457305083706 28550.76863440634 29043.855854885405 26200.729274381476 29179.511010534683 31838.541986540466 26587.429341033952 28880.79450240002 27269.434961609863 30643.925160263883 0.9019881480759264 0.9316942423364306 0.9477851059545956 0.8550056540523105 0.9522119264398898 1.0389838057634224 0.8676247968230255 0.9424639419185723 0.8898806148035586 1.0 14.90331348250942 DGKS(ph)PTVPCLQEEAGEPLGGK ddPTM_A459_Selumetinib_30min_R1 2 DGKSPTVPCLQEEAGEPLGGK 21 1 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 DGKS(0.5)PT(0.5)VPCLQEEAGEPLGGK;DGKS(0.841)PT(0.159)VPCLQEEAGEPLGGK 119.62 4.0936e-05 41731000.0 9964.2 11650.400000000001 11951.0 12103.7 10527.3 10059.2 12415.599999999999 12928.7 8679.7 8066.3 True False 10196.346473041895 10286.365751875981 10328.119842143984 9990.016009588284 9575.10757374577 9958.01358102283 11479.081296143095 12585.788877663821 14728.816959794069 9101.688177415614 1.1202698086650014 1.1301602023018054 1.1347477128222834 1.0976003368668368 1.0520144600761947 1.0940842387604588 1.2612035341560703 1.3827971945790725 1.618251106024625 1.0 13.151918445281286 -7.4637234449590135 3.0421448594373373 1.3723598974858822 1.1047947312384558 0.34009256074352145 0.14302964799252957 0.25244113153158315 4.610588868925381 0.06699705969197951 0.039783298302545476 3.4377679235768e-08 7.4637234449590135 -0.2675651662474263 DGKS(ph)PTVPCLQEEAGEPLGGK ddPTM_A459_Selumetinib_30min_R2 2 DGKSPTVPCLQEEAGEPLGGK 21 1 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 DGKS(0.5)PT(0.5)VPCLQEEAGEPLGGK;DGKS(0.635)PT(0.365)VPCLQEEAGEPLGGK 109.42 6.4268e-05 54603000.0 254180.0 268240.0 295060.0 277290.0 305930.0 238830.0 302340.0 306390.0 260530.0 426990.0 True False 240053.69316315927 288813.1454724579 276076.1608370381 239522.62364806922 267496.3383510988 271726.66461711883 316399.4090753448 307281.5441744048 312643.27981641534 414661.68924674555 0.5789145691255666 0.6965030842301877 0.6657865146368954 0.5776338394877387 0.6450953760329771 0.6552972499357835 0.7630302419548348 0.7410415578362151 0.7539719436930575 1.0 18.661575236686964 -9.03008607687059 0.3911537569034004 1.03814033049365 0.6194211314312758 0.8737851829353384 0.0410950482219783 0.8510973933418702 0.25013593869469014 0.1059145548484886 0.03376506838930399 9.3306934875934e-10 9.03008607687059 -0.4187191990623743 DGKSPT(ph)VPCLQEEAGEPLGGK ddPTM_A459_Selumetinib_30min_R2 2 DGKSPTVPCLQEEAGEPLGGK 21 1 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 DGKS(0.075)PT(0.925)VPCLQEEAGEPLGGK;DGKS(0.143)PT(0.857)VPCLQEEAGEPLGGK 114.53 0.00010873 14377700.0 74668.0 75914.0 77414.0 88728.0 80483.0 71588.0 86359.0 81788.0 71882.0 117709.0 True False 70518.25147968666 81736.35969801739 72433.26752199014 76643.0933356628 70372.00601285092 81448.5971888385 90374.86461711217 82025.98953926763 86260.4085508908 114310.43532528919 0.6169012590934095 0.7150384780306637 0.6336540256877627 0.6704820353239163 0.6156218879982023 0.7125211006069838 0.7906090494707293 0.717572191076424 0.7546153446570525 1.0 16.802597586692997 -10.505948993516283 0.24338598889831617 1.209646774023057 0.6265164036894986 0.8596524569107019 0.0403539361535094 5.653073810541715 0.32469464804759 0.874487836336643 0.07640039977957071 3.119255909110047e-11 10.505948993516283 -0.5831303703335584 DGLAFNALIHR ddPTM_A459_Selumetinib_30min_R1 2 DGLAFNALIHR 11 0 O43707;M0QZQ3;C9JY79;Q9H254-2;Q9H254-4;Q9H254 O43707 ACTN4;SPTBN4 Alpha-actinin-4;Spectrin beta chain, non-erythrocytic 4 0 ; 178.46 8.2837e-05 60739000.0 16378.5 15800.0 17456.9 15885.0 17961.9 13310.4 14273.400000000001 15290.0 10355.7 13705.5 False True 16760.08718298677 13950.128654779277 15086.348863887817 13110.982948380239 16337.249316431007 13176.509460876245 13196.745946419742 14884.459531080438 17572.86654959727 15464.734427875193 1.0837617200057894 0.902060667115897 0.9755323593979515 0.8477987778922141 1.0564196490166107 0.8520359352001272 0.8533444921390049 0.9624775388480769 1.136318675988523 1.0 13.916694438138139 -8.097596507266537 6.500530262211622 1.0657039795001317 0.9344923200933024 0.2697519702818615 0.08374571876386569 0.30353788054446057 16.941583428538056 0.05534365555094539 0.02059567562574986 7.987364297762557e-09 8.097596507266537 -0.13121165940682933 DGLAFNALIHR ddPTM_A459_Selumetinib_30min_R2 4 DGLAFNALIHR 11 0 O43707;M0QZQ3;C9JY79;Q9H254-2;Q9H254-4;Q9H254 O43707 ACTN4;SPTBN4 Alpha-actinin-4;Spectrin beta chain, non-erythrocytic 4 0 ;;; 183.03 4.6548e-05 9943800.0 140935.0 115993.0 140808.0 151969.0 156586.0 118131.0 118515.0 122695.0 106653.0 129071.0 False True 133102.39690750604 124889.2901237204 131748.56658015892 131270.56003885294 136914.26678339887 134402.47296355086 124026.18233301745 123052.0221367493 127986.58013380451 125344.384863268 1.0618935746719 0.996369245099858 1.0510926893444563 1.0472791436333546 1.09230474849553 1.0722656073518082 0.9894833539476977 0.9817114844911535 1.0210794865156405 1.0 16.93553784267595 -7.26971220382293 24.74180425570031 0.9965445345084523 1.0523027662445177 0.5457712716344187 0.024758234448765997 466.05962231906193 1393853.4744564798 0.011109088260072763 0.00762858858299101 5.373877919581071e-08 7.26971220382293 0.05575823173606542 DGLAPEKTS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 1 DGLAPEKTSPDR 12 1 Q7L4I2;E9PI52 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 DGLAPEKT(0.041)S(0.959)PDR 120.29 0.019314 8651400.0 3250.7 4594.2 2165.5 2155.1 2701.0 2439.9 3691.0 3570.5 1886.3 3617.9 True False 3326.4349852388846 4056.3089282143656 1871.4369942400456 1778.752241237284 2456.695026900281 2415.3568212519504 3412.5848983588535 3475.798741381474 3200.9133300989133 4082.2927063302836 0.8148448003448371 0.9936350036645766 0.45842792980965497 0.43572383687211563 0.6017929638143685 0.5916667409729175 0.8359481163776092 0.8514330038097615 0.7840969671614574 1.0 11.995163914076207 -7.320366784141193 6.237388164299638 0.8576566335709561 0.6445821114416663 0.3053173238276389 0.16117929707082676 0.35134103939098504 28.947978897646085 0.07571607349495973 0.050932842053868506 4.782260351140961e-08 7.320366784141193 -0.2130745221292898 DGLAPEKTS(ph)PDRDK ddPTM_A459_Selumetinib_30min_R1 1 DGLAPEKTSPDRDK 14 2 Q7L4I2;E9PI52 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 DGLAPEKT(0.034)S(0.966)PDRDK 159.41 0.009746799999999998 15178000.0 5205.8 5900.2 4507.2 4685.1 4153.1 5038.3 5421.4 5901.5 3364.7 6006.6 True False 5327.085011276524 5209.401841071438 3895.146996277412 3866.9352352191563 3777.45283828936 4987.619276410384 5012.459433205821 5744.973049226369 5709.650152035106 6777.605619238639 0.7859833266419743 0.7686197949146287 0.574708416969675 0.5705459202646181 0.5573432640528441 0.735896946002985 0.7395619802630085 0.8476405049179786 0.8424287975428848 1.0 12.726559975228138 -8.009434511577465 0.9359931772237717 0.9768606104021562 0.6532726700600281 0.6504432325000484 0.07975658613301927 0.3713880214425437 0.6180656735417154 0.08244376267334566 0.03128847989180604 9.785104958661427e-09 8.009434511577465 -0.3235879403421281 DGLGFCALIHR ddPTM_A459_Selumetinib_30min_R1 2 DGLGFCALIHR 11 0 P12814-4;P12814-3;P12814;P12814-2;H9KV75;G3V2N5;G3V2W4;G3V2X9 P12814-4 ACTN1 Alpha-actinin-1 0 ; 140.3 0.001542 15011500.0 14950.2 18462.5 18278.9 19068.4 17789.7 15461.3 14906.6 14627.2 9521.8 13442.5 False True 15298.51057197476 16300.901917016616 15796.725778810607 15738.461898199173 16180.624776026621 15305.773359737188 13782.183160627483 14239.239140158255 16157.799155243521 15167.975816038268 1.0086059443606488 1.0746919770125436 1.0414524634267621 1.0376112204476016 1.0667623005383224 1.0090847681569493 0.9086369419217112 0.9387699000088076 1.0652574444481009 1.0 13.8887409486537 -7.001077187473524 11.705596420294421 0.971031423491113 1.0458652937855215 0.36523802570637265 0.041707489777496956 0.093591677982813 543.0517540660148 0.014993189047905435 0.012754017983170864 9.975227576228233e-08 7.001077187473524 0.07483387029440847 DGLNDDDFEPYLS(ph)PQAR ddPTM_A459_Selumetinib_30min_R1 4 DGLNDDDFEPYLSPQAR 17 0 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 DGLNDDDFEPYLS(1)PQAR;DGLNDDDFEPYLS(1)PQAR;DGLNDDDFEPYLS(1)PQAR;DGLNDDDFEPYLS(1)PQAR 277.64 1.4950999999999991e-63 45099900.0 4397.87 6482.389999999999 4313.09 3936.6200000000003 5761.27 5326.57 5301.78 7128.9 4299.93 5681.01 True False 4500.331814234637 5723.428765218649 3727.396068107502 3249.1632165094497 5240.164145734831 5272.9895419386 4901.862466112432 6939.818414069286 7296.667155538476 6410.222971223475 0.7020554252851036 0.8928595449662272 0.5814768198922852 0.5068721058683088 0.8174698710573367 0.8225906595776623 0.7646945337342684 1.0826173200562992 1.1382860141206308 1.0 12.646158824639286 -7.730519503735509 4.166405308359065 1.0883770131825081 0.7224284212222162 0.6685941344267743 0.11203141642937271 0.13133924839867955 4.994356349325817 0.0646477795782737 0.03324588744969096 1.859861036827955e-08 7.730519503735509 -0.36594859196029195 DGLNDDDFEPYLS(ph)PQAR ddPTM_A459_Selumetinib_30min_R2 2 DGLNDDDFEPYLSPQAR 17 0 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 DGLNDDDFEPYLS(1)PQAR;DGLNDDDFEPYLS(1)PQAR 264.69 9.679e-41 20828200.0 22988.2 13093.2 16024.1 19125.7 22373.7 22295.0 27130.0 25390.0 23862.7 20679.3 True False 21710.60787305585 14097.406338726434 14993.126851720921 16520.74666632725 19562.915782584198 25365.93387614064 28391.598757075124 25463.88069645922 28635.9067795462 20082.23487772605 1.0810852479937825 0.7019839387678106 0.746586569821985 0.8226547875232264 0.9741403734044637 1.2631031372048604 1.413766890485147 1.267980424066355 1.4259322706810558 1.0 14.293632209973515 -6.656226617414288 2.7009794100693867 1.3059552980804707 0.8246498353818741 0.6722859089484965 0.1444572502920713 0.1459706983000633 2.160543303161003 0.05030153801679673 0.04960468588666537 2.2068528837132543e-07 6.656226617414288 -0.48130546269859664 DGLNQTTIPVS(ph)PPSTTK ddPTM_A459_Selumetinib_30min_R2 2 DGLNQTTIPVSPPSTTK 17 0 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 DGLNQTTIPVS(1)PPSTTK;DGLNQTTIPVS(0.8)PPS(0.181)T(0.015)T(0.004)K 265.42 5.876899999999999e-41 6736200.0 40251.0 35068.0 42523.0 46825.0 46864.0 41562.0 45661.0 45901.0 47675.0 44302.0 True False 38014.01055751956 37757.60283860772 39787.11647554178 40447.35422236953 40976.52535052431 47286.78823772851 47784.32697555504 46034.564310680405 57211.332150798735 43022.88614958044 0.8835764859045906 0.8776166877167059 0.9247895721642511 0.9401357705697292 0.9524355295007078 1.0991077649538317 1.1106722782246685 1.0700017695379402 1.3297883352569237 1.0 15.392816689387606 -6.7143684994582085 1.13849986200185 1.1465747781536775 0.8920095170190139 0.627900884702015 0.0800534396978391 0.29602223463852084 0.81532608034847 0.03923227948912627 0.03707361632953182 1.9303297345419501e-07 6.7143684994582085 -0.2545652611346636 DGLNQTTIPVS(ph)PPSTTKPSR ddPTM_A459_Selumetinib_30min_R1 3 DGLNQTTIPVSPPSTTKPSR 20 1 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 DGLNQTTIPVS(0.995)PPS(0.001)T(0.001)T(0.001)KPS(0.001)R;DGLNQTTIPVS(0.997)PPS(0.001)T(0.001)T(0.001)KPSR;DGLNQTTIPVS(0.996)PPS(0.001)T(0.001)T(0.001)KPS(0.002)R 147.08 1.2337e-05 675904000.0 10410.3 11465.7 12327.6 13349.8 11936.3 10498.1 11092.6 10504.0 5799.6 9465.3 True False 10652.839735082398 10123.290513740683 10653.579630659702 11018.508036782281 10856.663772524927 10392.498645512149 10255.876251296504 10225.399798199405 9841.497613975333 10680.263454829606 0.997432299318908 0.9478502619860879 0.9975015762220886 1.031670059768022 1.0165164762499892 0.9730563941110151 0.9602643506568936 0.957410820570675 0.9214658098649257 1.0 13.38265961461689 -6.983002070514648 4.635416697207558 0.9572232255559334 0.9972559929154403 0.3157225383981871 0.026702729168325 0.24911220927103256 13.676285611314242 0.010533961680026807 0.00887158319685106 1.0399152079838794e-07 6.983002070514648 0.04003276735950689 DGLNQTTIPVS(ph)PPSTTKPSR ddPTM_A459_Selumetinib_30min_R2 5 DGLNQTTIPVSPPSTTKPSR 20 1 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 DGLNQTTIPVS(0.803)PPS(0.065)T(0.065)T(0.065)KPS(0.002)R;DGLNQTTIPVS(0.483)PPS(0.163)T(0.163)T(0.163)KPS(0.027)R;DGLNQTTIPVS(0.996)PPS(0.002)T(0.002)TKPSR;DGLNQTTIPVS(0.999)PPSTTKPSR;DGLNQTTIPVS(0.999)PPSTTKPSR 121.92 0.0001344 1070277000.0 501788.0 472663.0 488310.0 560563.0 563564.0 436682.0 447946.0 437457.0 406214.0 530173.0 True False 473900.6317765183 508914.73224891257 456892.6662317278 484213.35237488756 492764.0519939168 496830.9816954854 468776.3765881598 438729.92744509527 487468.15056747844 514865.5279351165 0.9204357372246514 0.9884420390114875 0.8874019359270554 0.9404656674468761 0.9570733041113894 0.9649723175059726 0.9104831284164652 0.852125270853993 0.9467873145877215 1.0 18.9738361542791 -7.287348921169562 23.931139301674357 0.9150260287124717 0.943170728295157 0.0 0.043080084689436575 1182.1772914072963 1091901.69497015 0.017437589173634836 0.011762169375820442 5.160016363044466e-08 7.287348921169562 0.028144699582685284 DGLNQTTIPVSPPS(ph)TTK ddPTM_A459_Selumetinib_30min_R1 1 DGLNQTTIPVSPPSTTK 17 0 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 DGLNQTTIPVS(0.336)PPS(0.625)T(0.03)T(0.009)K 114.28 0.0021844 0.0 649.61 1026.9 654.8 706.97 603.13 791.31 564.97 626.94 405.17 561.49 True False 664.7446490789771 906.6700706071416 565.8817565589388 583.5109609704994 548.57699799125 783.3501398519941 522.3538580400434 610.3115146118754 687.5438975540359 633.562710875754 1.0492168141652802 1.43106602557761 0.8931740249938923 0.9209995332015837 0.8658606142286517 1.2364208410706394 0.8244706468251737 0.9633008763540721 1.085202594394587 1.0 9.307343616073343 -5.27704237197341 24.981949834193408 0.9706907060011584 1.2401414425938868 0.36397492534615017 0.1408514382346084 700.5903920539278 1121714.720584364 0.03530946004219796 0.07389877919416757 5.283936964899476e-06 5.27704237197341 0.26945073659272845 DGMDNQGGYGS(ph)VGR ddPTM_A459_Selumetinib_30min_R2 2 DGMDNQGGYGSVGR 14 0 P31942;P31942-4;P31942-3;P31942-2 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 DGMDNQGGYGS(1)VGR;DGMDNQGGYGS(1)VGR 163.02 0.00027126 11448900.0 26216.0 27308.2 31742.0 30201.0 28022.6 29218.0 25953.3 22133.4 23046.6 26000.7 True False 24759.01967096304 29402.651130297363 29699.754278076503 26087.571700369077 24502.150462777445 33242.51428540378 27160.179875488306 22197.804529618377 27656.563975807 25249.992233068395 0.980555536113696 1.1644617890927698 1.1762282540103328 1.0331714742550993 0.9703824950365114 1.316535624191918 1.0756510190097506 0.8791212418888291 1.095309801307062 1.0 14.623995323639013 -7.538981478868537 24.664094129726884 0.987806474994382 1.1108515113213884 0.18663724982624075 0.1075709234042786 332.24610922431935 508884.55420962576 0.05018335623953544 0.028983754251955228 2.8908031623194756e-08 7.538981478868537 0.12304503632700636 DGMDNQGGYGSVGR ddPTM_A459_Selumetinib_30min_R2 1 DGMDNQGGYGSVGR 14 0 P31942;P31942-4;P31942-3;P31942-2 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 178.71 0.010617 10864000.0 24114.0 21834.0 21539.0 23273.0 25245.0 17178.0 18958.0 18766.0 20392.0 22850.0 False True 22773.840415990326 23508.597592624665 20153.20418989003 20103.177251835696 22073.49740683651 19544.113573641793 19839.58456456433 18820.605953121456 24470.969800085735 22190.261128570106 1.0262988922950915 1.059410588114134 0.9082004070669836 0.9059459523868659 0.9947380645474577 0.8807518514722938 0.8940671968488346 0.848147114811993 1.102779713059762 1.0 14.437639024401927 -5.258773159784792 24.896532764822933 0.9331264662809389 1.0428547488412825 0.2376219985184176 0.07102730700651037 272.1541483256717 2541274.015561323 0.017662765714859426 0.04252141901811505 5.510954688223592e-06 5.258773159784792 0.10972828256034362 DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_A459_Selumetinib_30min_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 135.68 1.4405e-12 57174000.0 1622.9 2246.6 1355.4 1268.3 1578.2 1612.4 1834.1 1745.7 1193.4 1525.4 False True 1660.7104123863119 1983.5670275839955 1171.3441246792697 1046.8152139396068 1435.4520886538412 1596.180719942065 1695.7523603576183 1699.3983651672418 2025.1126375126155 1721.1999486542516 0.9648561828535759 1.1524326555638582 0.6805392514652957 0.6081891965881573 0.833983343873658 0.9273650752720886 0.9852152050570708 0.9873334974800251 1.1765702404859952 1.0 10.749198987023382 -7.388487607867046 1.578386070677418 1.0671392451221908 0.8465302861242995 0.2771176653317471 0.14670156453930527 0.5984306314722107 2.8901675835221536 0.10103833764610562 0.0545978167178629 4.088014166600455e-08 7.388487607867046 -0.22060895899789135 DGPIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DGPISPK 7 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 DGPIS(1)PK 86.882 0.034321 35220000.0 9934.5 14029.0 8618.4 8827.5 6932.0 9709.5 9843.1 10446.0 6807.5 12574.0 True False 10165.954520828032 12386.478158094835 7448.068617482524 7285.942837697613 6305.001823944004 9611.831245520632 9100.627042274724 10168.938146609957 11551.8302998719 14187.99538113187 0.7165180314582981 0.8730252460165858 0.5249556697338269 0.513528700988086 0.44438989826066694 0.6774622480003819 0.6414314917509303 0.7167283237301642 0.8141974951045081 1.0 13.792383145269328 -8.449678666578693 1.1855913338516475 0.997384527307573 0.6200562697819693 0.5208402716073331 0.11323853291389695 0.4230338103869535 1.294750023206904 0.11952358345700438 0.03782869605612165 3.550760119344448e-09 8.449678666578693 -0.3773282575256037 DGPIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 DGPISPK 7 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 DGPIS(1)PK 93.667 0.025408 19726000.0 267820.0 183060.0 184580.0 207540.0 163970.0 183600.0 286610.0 277230.0 193360.0 175830.0 True False 252935.6365684052 197100.11336932587 172704.32375550846 179272.6939735303 143370.62268960138 208889.23344514106 299937.932906941 278036.6934021028 232037.40292980432 170753.33103879596 1.4812925465620173 1.1542973256817097 1.0114257959411006 1.0498928066756055 0.8396358760171238 1.2233391417569501 1.7565568477185003 1.6282944040425866 1.3589041075695578 1.0 17.38155419717635 -7.0131250903661115 23.8632873070274 1.4885326756616455 1.0944111880079126 0.2851429601679021 0.23955802942914198 371.4925050831499 675426.0619775271 0.08853571384132389 0.07196691998743528 9.702304703369377e-08 7.0131250903661115 -0.3941214876537329 DGPPLLENAHS(ph)S ddPTM_A459_Selumetinib_30min_R2 2 DGPPLLENAHSS 12 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 DGPPLLENAHS(0.595)S(0.405);DGPPLLENAHS(0.586)S(0.414) 113.53 0.0061717 1163400.0 20456.0 19401.2 27324.0 32738.0 36659.0 24967.0 24112.0 27624.0 21231.2 29345.0 True False 19319.13741185611 20889.209655309576 25566.003588121795 28279.027923799982 32053.568684381844 28405.97762213963 25233.255777021583 27704.38126660061 25478.033249292894 28497.733602533477 0.6779183805037261 0.7330130159351516 0.8971240992248223 0.9923255062390628 1.1247760657546553 0.9967802358716102 0.8854478089014882 0.9721608620882631 0.8940371751888323 1.0 14.79855956723381 -5.316767986255462 2.328311435427683 0.9817100723529244 0.6836829365152447 0.7548453143579967 0.06225063884484863 0.16433479457375838 1.6835411811898298 0.019149657313005542 0.0608141051239067 4.822053380537053e-06 5.316767986255462 -0.2980271358376797 DGPSS(ph)APATPTK ddPTM_A459_Selumetinib_30min_R1 2 DGPSSAPATPTK 12 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 DGPS(0.006)S(0.994)APATPTK;DGPS(0.123)S(0.877)APATPTK 232.78 3.2738e-10 35034000.0 11979.099999999999 14658.400000000001 13062.5 13451.2 12486.9 11800.5 13008.0 12910.7 7400.6 10421.099999999999 True False 12258.189722728988 12942.187713494728 11288.684247176454 11102.20043029603 11357.462099741244 11681.79768399673 12026.79608719911 12568.266296136062 12558.277681561813 11758.749695110004 1.0424739058631958 1.1006431847832316 0.9600241981399578 0.9441650445976407 0.9658732768556474 0.9934557658672439 1.0227954841321758 1.068843765027391 1.0679943027262755 1.0 13.521447046478807 -7.533810344892073 4.548739337805342 1.051080055344855 0.9999643809047938 0.15569986457288987 0.04591894964916161 0.3660334790991954 19.43100070716967 0.02438185815491235 0.014343925554599115 2.925429625350201e-08 7.533810344892073 -0.051115674440061154 DGPSS(ph)APATPTK ddPTM_A459_Selumetinib_30min_R2 3 DGPSSAPATPTK 12 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 DGPS(0.034)S(0.966)APATPTK;DGPS(0.005)S(0.995)APATPTK;DGPS(0.046)S(0.954)APATPTK 169.09 0.00036182 46434000.0 243878.0 239400.0 257861.0 285658.0 275567.0 206410.0 212072.0 220390.0 198668.0 229459.0 True False 230324.23708098574 257761.21020767305 241270.5039978283 246750.88761246417 240947.80985976284 234841.10389657717 221933.76821269607 221031.29841247134 238407.15124771665 222833.9224639204 1.033613888470137 1.1567413406251368 1.0827368711641874 1.1073308986535306 1.0812887337598938 1.0538839926160743 0.9959604254088824 0.9919104594510697 1.06988715457503 1.0 17.765609348251125 -6.898424531576335 2.3886569440683223 1.0141137746893234 1.0977464015068343 0.520796060856756 0.03507090931186939 0.2214369870413029 2.570018744309816 0.01352805405503221 0.011471822585359172 1.263500646356359e-07 6.898424531576335 0.08363262681751094 DGPSSAPATPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 DGPSSAPATPTK 12 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 DGPSS(0.001)APAT(0.422)PT(0.576)K 99.941 0.032517000000000004 2737200.0 18152.0 16442.0 22195.0 20879.0 20149.0 17211.0 20275.0 20982.0 18726.0 20325.0 True False 17143.184508213326 17703.048530637287 20766.997864088833 18035.24418171604 17617.702485654554 19581.659024097622 21217.827674150336 21043.054146242903 22471.723248156428 19738.164439307988 0.8685298250972703 0.896894368525078 1.0521240679671284 0.9137244872577598 0.8925704586070529 0.9920709235303213 1.074964581402293 1.0661099825643496 1.1384910343235684 1.0 14.268700211418885 -7.083560398573832 3.130229244533699 1.0756924518170057 0.9299000301875789 0.5943031610254211 0.056165646840378315 0.1904394694793721 3.603116326120264 0.023554543053995732 0.01812117505716859 8.249727461847092e-08 7.083560398573832 -0.14579242162942674 DGQAMLWDLNEGK ddPTM_A459_Selumetinib_30min_R1 2 DGQAMLWDLNEGK 13 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6REE5;D6RAC2;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 ; 274.53 1.5427e-36 76275000.0 7155.1 7747.3 7887.6 7900.7 7579.799999999999 6662.400000000001 7235.2 7017.0 4324.9 6125.0 False True 7321.799908598991 6840.242514377943 6816.50724348547 6520.99105950694 6894.208428322381 6595.3823049752 6689.443038907059 6830.886365571713 7339.03942180183 6911.2034125523 1.0594102751050498 0.9897324830512909 0.9862981649628717 0.9435391595714508 0.9975409515224148 0.9543030223935389 0.9679129146680195 0.9883787175421993 1.0619047051158246 1.0 12.754721226268163 -8.128585747560647 7.435266130013697 1.0305464367296224 0.9830271475981648 0.23175628294518624 0.03260958396598546 0.35342727135677815 19.43043089299297 0.022174839997058403 0.008298115664823205 7.4372820592870285e-09 8.128585747560647 -0.04751928913145764 DGQAMLWDLNEGK ddPTM_A459_Selumetinib_30min_R2 1 DGQAMLWDLNEGK 13 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6REE5;D6RAC2;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 134.04 0.017474 3446200.0 19511.0 17532.0 20136.0 21225.0 19851.0 11668.0 14958.0 15136.0 16887.0 18280.0 False True 18426.656728721384 18876.648025734874 18840.471682419146 18334.118384832756 17357.13990980835 13275.161088441748 15653.576638714705 15180.0432541003 20264.871862203217 17752.20890285609 1.037992332647504 1.0633408005185132 1.0613029502704854 1.032779553528296 0.977745361424618 0.7478033387893466 0.881781908064199 0.8551072904317859 1.1415408624975607 1.0 14.115710929514565 -6.4186974419149685 4.007539331460841 0.909407229090041 1.049948005484456 0.2529280562044951 0.09677654038453411 0.29815255593296497 8.40094161512269 0.03149898284424838 0.03555082202718021 3.813313913915501e-07 6.4186974419149685 0.1405407763944151 DGQDAIAQS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 4 DGQDAIAQSPEK 12 0 Q9NWH9;H7BXE3;H0YL55 Q9NWH9 SLTM SAFB-like transcription modulator 1 DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK 154.88 0.0004303 323201000.0 33097.1 49483.8 27765.3 28340.6 24817.4 31511.999999999996 36754.3 31678.0 20266.9 35862.9 True False 33868.19803425414 43690.21369160552 23994.92476387586 23391.446228949637 22572.670551867846 31195.017890606745 33981.89355994333 30837.796535354242 34391.44906419007 40466.25254922808 0.836949208307657 1.0796703657808546 0.5929613752764853 0.5780482440397324 0.5578147006424107 0.7708897148965629 0.8397588464265037 0.7620620787121167 0.8498797614716639 1.0 15.304431631349646 -8.642497945667694 0.9592117801346239 0.998902147329628 0.7395521069329708 0.21919620021665387 0.14652723678783922 1.2528707246555397 2.4454110260123927 0.15637984555762252 0.05225952401120557 2.277729016116333e-09 8.642497945667694 -0.2593500403966572 DGQDAIAQS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 5 DGQDAIAQSPEK 12 0 Q9NWH9;H7BXE3;H0YL55 Q9NWH9 SLTM SAFB-like transcription modulator 1 DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK;DGQDAIAQS(1)PEK 158.91 0.00045847 772354000.0 924920.0 708783.0 698289.0 702899.0 641268.0 608800.0 869689.0 828080.0 637445.0 597270.0 True False 873516.6491481202 763144.3770034463 653361.8459795784 607162.9436315919 560706.180831342 692656.673863845 910131.2617560594 830489.5757039771 764951.8117014335 580025.2632061726 1.5059975910697958 1.3157088585849805 1.1264368768491693 1.0467870662657206 0.9666926880597552 1.1941836292355372 1.5691234839068537 1.43181621282033 1.3188249895755453 1.0 19.145756213139983 -7.040684855574673 24.54473878438986 1.368172755321618 1.1767338739565303 0.09271998663350045 0.19330803580043063 765.3750144693234 461740.0386060151 0.07671882420568783 0.059434772050688624 9.105737879591286e-08 7.040684855574673 -0.1914388813650878 DGQDAIAQS(ph)PEKESK ddPTM_A459_Selumetinib_30min_R1 5 DGQDAIAQSPEKESK 15 1 Q9NWH9;H7BXE3;H0YL55 Q9NWH9 SLTM SAFB-like transcription modulator 1 DGQDAIAQS(0.995)PEKES(0.005)K;DGQDAIAQS(1)PEKESK;DGQDAIAQS(1)PEKESK;DGQDAIAQS(1)PEKESK;DGQDAIAQS(1)PEKESK 149.19 0.0013765 852306000.0 17680.9 25520.1 24987.000000000004 27811.499999999996 17010.3 23356.0 21421.800000000003 19895.4 12936.8 18800.6 True False 18092.830568957514 22532.194828027372 21593.902643766356 22954.74361151258 15471.72136841238 23121.05984555126 19805.936379209885 19367.709362632955 21952.804733511977 21213.84014335196 0.8528786135228554 1.0621459705440723 1.0179157803512298 1.0820645133741231 0.7293220493726092 1.0899045005200054 0.9336327720663395 0.9129751724231056 1.03483407931645 1.0 14.372718181667262 -4.734024299585319 24.484076243363717 0.979818719277986 0.8528777508306071 0.12966786876101166 0.10177721133624831 5101.328737007578 4555621.259920274 0.02457337089759387 2.1510961652443084 1.8449121900176106e-05 4.734024299585319 -0.1269409684473789 DGQDAIAQS(ph)PEKESK ddPTM_A459_Selumetinib_30min_R2 5 DGQDAIAQSPEKESK 15 1 Q9NWH9;H7BXE3;H0YL55 Q9NWH9 SLTM SAFB-like transcription modulator 1 DGQDAIAQS(0.999)PEKES(0.001)K;DGQDAIAQS(1)PEKESK;DGQDAIAQS(0.999)PEKES(0.001)K;DGQDAIAQS(0.999)PEKES(0.001)K;DGQDAIAQS(1)PEKESK 175.21 9.6534e-05 953452000.0 473057.0 441668.0 400081.0 345160.0 310784.0 244881.0 311665.0 314841.0 191237.0 340092.0 True False 446766.38573721243 475542.5154135451 374340.2240352564 298148.6125657886 271740.5354757887 278611.1349416102 326158.0400524811 315757.13518526684 229489.74360822877 330272.660294865 1.3527198567945122 1.439848260491753 1.1334278280892163 0.9027347655709792 0.822776354643405 0.8435791648417651 0.9875417473589536 0.956049873772056 0.6948493508464855 1.0 18.33329802386801 -5.529126459941728 2.5543530061473962 0.882940788562397 1.3982749488051536 0.8443362762841693 0.0877302838941647 0.09976691764391506 1.2951749695827617 0.024891141921093304 0.05646134681593779 2.957151263742704e-06 5.529126459941728 0.5153341602427566 DGQDAIAQS(ph)PEKESKDYEMNANHK ddPTM_A459_Selumetinib_30min_R1 1 DGQDAIAQSPEKESKDYEMNANHK 24 2 Q9NWH9;H7BXE3;H0YL55 Q9NWH9 SLTM SAFB-like transcription modulator 1 DGQDAIAQS(0.878)PEKES(0.115)KDY(0.007)EMNANHK 51.777 0.011946 20346000.0 1870.1 1280.7 5337.3 5956.6 2562.8 2925.2 1638.0 1675.8 1443.0 1155.2 True False 1913.6696914188456 1130.755048618723 4612.523975690327 4916.391629230206 2330.9951924990883 2895.775143869094 1514.4443412386343 1631.3523402344404 2448.6656074498933 1303.481172600885 1.4681222342478706 0.8674885931512805 3.5386195617131806 3.771739655756089 1.788284511887476 2.221570364603767 1.161845965305971 1.2515350236930094 1.878558477805996 1.0 10.348154029490678 -7.187455271415846 4.605681435212447 1.3441391246982062 2.3277592352657 0.23177742023555858 0.846726860957901 0.381709885621632 15.282068914777636 0.37081507123900875 0.28083820719274444 6.494485157250027e-08 7.187455271415846 0.983620110567494 DGQDAIAQSPEKES(ph)KDYEMNANHK ddPTM_A459_Selumetinib_30min_R1 1 DGQDAIAQSPEKESKDYEMNANHK 24 2 Q9NWH9;H7BXE3;H0YL55 Q9NWH9 SLTM SAFB-like transcription modulator 1 DGQDAIAQS(0.332)PEKES(0.598)KDY(0.07)EMNANHK 44.878 0.028868 15955000.0 978.79 641.2 2614.1 2298.0 1139.5 1174.2 829.0 750.88 754.29 504.37 True False 1001.5939026061977 566.1280059142072 2259.119578223461 1896.6974388025053 1036.4324261950646 1162.3886140882985 766.4678625682709 730.9642231980168 1279.9750388381008 569.1108024798378 1.759927764930594 0.9947588473938055 3.969560177701065 3.3327384237618656 1.82114347799923 2.0424645060738924 1.3467814338235566 1.2843970278070993 2.249078796713663 1.0 9.152565753775548 -6.73435174847133 2.2471049367308638 1.5335819502857913 2.4912423515058886 0.21257019997965976 0.8302578314030006 0.5333177712469174 5.529805188661596 0.3458456334580498 0.3246060324984523 1.843521689380321e-07 6.73435174847133 0.9576604012200973 DGQPCMDHDR ddPTM_A459_Selumetinib_30min_R2 3 DGQPCMDHDR 10 0 A0A6I8PTV8;A0A6I8PIP7;A0A6I8PS05;A0A6I8PLB8;A0A6I8PRS0;A0A6I8PL42;B4DER1;A0A6I8PIT3;A0A6I8PIV1;Q9P2J5-2;Q9P2J5;A0A6I8PRU9;A0A6I8PLB3 A0A6I8PTV8 LARS Leucine--tRNA ligase, cytoplasmic 0 ;; 108.35 0.015082 8968800.0 63053.1 54030.6 68349.0 75619.0 77518.0 57236.3 56431.5 68088.7 55209.8 71837.0 False True 59548.861123558076 58174.573284238584 63951.49975276453 65319.561749948974 67779.49582028734 65120.08078559986 59055.67656689591 68286.8268443089 66253.30269070105 69762.87915505865 0.8535894998141009 0.8338900857995943 0.9166981140589476 0.9363082851664748 0.971569646224564 0.9334488710086138 0.8465200588358124 0.9788418664965218 0.9496927806468963 1.0 16.090171961765925 -2.154467715713878 0.35638683977726826 0.9559967749599526 1.1380026950334815e-25 0.463687036894461 0.04080322146449417 39.434552333616864 0.8476316755026951 0.03594790084478005 23.67170822400508 0.007007002691067116 2.154467715713878 -0.9559967749599526 DGQS(ph)SPQPSPR ddPTM_A459_Selumetinib_30min_R2 1 DGQSSPQPSPR 11 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 DGQS(0.5)S(0.5)PQPSPR 87.831 0.031501 2260500.0 5532.5 5230.6 5669.3 7219.6 7701.8 5456.8 5563.7 4679.3 5670.0 5901.1 True False 5225.025798352265 5631.77020097016 5304.543410267122 6236.278025495334 6734.231029034399 6208.4246681015575 5822.423074262399 4692.915988300182 6804.15843303679 5730.719910100877 0.9117573150177374 0.9827334592018168 0.9256329908773621 1.0882189538705893 1.1751108298217035 1.083358594643351 1.0160020321355938 0.8189051396541858 1.1873130321801082 1.0 12.484500670676205 -5.754941271194351 24.995353877988787 1.0500042660557454 0.9443104544034429 0.21483497561176823 0.09850203147150044 271.6108256536032 1044753.3297597641 0.02805820490920148 0.04715848769593654 1.7581613506544392e-06 5.754941271194351 -0.10569381165230252 DGQSS(ph)PQPSPR ddPTM_A459_Selumetinib_30min_R1 2 DGQSSPQPSPR 11 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 DGQS(0.205)S(0.795)PQPSPR;DGQS(0.19)S(0.81)PQPSPR 184.11 2.7052e-05 3881000.0 1953.05 2482.48 2835.87 3079.5 2218.17 2489.77 2297.5 2203.6 1475.6399999999999 1797.46 True False 1998.5522650262428 2191.8300875263585 2450.7744303188733 2541.7231343743765 2017.5369151497207 2464.7251743302872 2124.197725272138 2145.1533696984225 2504.053303518614 2028.1814997430633 0.9853912311493946 1.0806873486441064 1.2083605094659158 1.2532029972151755 0.994751660739095 1.2152389589602937 1.0473410419832931 1.057673275281417 1.2346297921738443 1.0 10.985971047980959 DGQSS(ph)PQPSPR ddPTM_A459_Selumetinib_30min_R2 2 DGQSSPQPSPR 11 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 DGQS(0.203)S(0.789)PQPS(0.007)PR;DGQS(0.068)S(0.931)PQPS(0.001)PR 154.67 0.00053883 72405200.0 34793.9 28635.1 32877.0 37734.6 38021.0 27716.3 33409.8 37891.4 24908.6 32729.1 True False 32860.19432901741 30831.320093641403 30761.729613771073 32595.08238418421 33244.462067947374 31533.9687414791 34963.42190026278 38001.65770074107 29891.01600443389 31784.125842585738 1.0338555319017113 0.9700225907214436 0.9678331178941906 1.0255145145603444 1.0459454582011822 0.9921294956373642 1.100027796058411 1.195617519542564 0.9404385117423812 1.0 14.956018790148097 -6.580899625443268 1.257552607635521 1.067085240038251 0.9928018953692342 0.08855127193220991 0.06774851033476209 0.8200940544191279 2.7168513903137628 0.03071460563082314 0.03275376301807106 2.6248251253825176e-07 6.580899625443268 -0.07428334466901665 DGQVINETS(ph)QHHDDLE ddPTM_A459_Selumetinib_30min_R1 4 DGQVINETSQHHDDLE 16 0 P08670 P08670 VIM Vimentin 1 DGQVINET(0.09)S(0.91)QHHDDLE;DGQVINET(0.087)S(0.913)QHHDDLE;DGQVINET(0.37)S(0.63)QHHDDLE;DGQVINET(0.411)S(0.589)QHHDDLE 160.76 3.4213e-05 297999000.0 12721.599999999999 15433.4 17170.3 17499.3 15363.0 13582.1 15562.900000000001 13816.9 8799.2 11297.7 True False 13017.988528075497 13626.450353206992 14838.667569706702 14443.375757544241 13973.419362557943 13445.476405560104 14388.977923237322 13450.430928383608 14931.599731859398 12747.869843917095 1.0211893192718229 1.0689197897411173 1.1640115369382495 1.133003076936512 1.0961375926838195 1.05472338282273 1.1287358672008496 1.0551120377811007 1.1713015519204029 1.0 13.637968573899132 -10.550559342221508 4.334682398580872 0.9999944907438926 1.099413110210743 0.2839659741925211 0.04727399346608922 33282073.252712533 2.6621582769963554 2014.290904842485 0.011400674260085442 2.8147553792319018e-11 10.550559342221508 0.09941861946685038 DGQVINETS(ph)QHHDDLE ddPTM_A459_Selumetinib_30min_R2 3 DGQVINETSQHHDDLE 16 0 P08670 P08670 VIM Vimentin 1 DGQVINET(0.123)S(0.877)QHHDDLE;DGQVINET(0.244)S(0.756)QHHDDLE;DGQVINET(0.059)S(0.941)QHHDDLE 130.47 0.00078405 169916000.0 156486.0 146388.0 165515.0 192227.0 179598.0 140273.0 131927.0 137483.0 132468.0 172830.0 True False 147789.1345830914 157615.48888839124 154865.94509910615 166045.35098992867 157035.29361350852 159594.33247848717 138061.8669083912 137883.0527684641 158965.30146517098 167839.948833732 0.8805361036513206 0.939082083756654 0.9227001448416888 0.9893076835623853 0.9356252471756474 0.9508721468724158 0.8225804873496477 0.8215151024924096 0.9471243441729564 1.0 17.356726617656882 -7.216138243699303 24.999854376125157 0.8829311322108206 0.9382311645185007 0.0776830883049735 0.056201490813273795 743.4646636314911 410288.34084769385 0.021011649946905252 0.016275477843483807 6.079414518403753e-08 7.216138243699303 0.0553000323076801 DGQVINETSQHHDDLE ddPTM_A459_Selumetinib_30min_R1 9 DGQVINETSQHHDDLE 16 0 P08670 P08670 VIM Vimentin 0 ;;;;;;;; 168.76 5.1912e-05 258389200.0 53917.399999999994 63104.899999999994 66038.9 73097.8 73204.5 60277.8 67648.4 53157.1 29110.39 45944.799999999996 False True 55173.570515002626 55716.54897132787 57071.18010571178 60332.641445647365 66583.1659003042 59671.460059863435 62545.626723960726 51747.201029404605 49398.20569123583 51842.262620250294 1.0642585359199017 1.0747322002408943 1.1008620615917908 1.1637733076503611 1.2843414337069445 1.1510195937427112 1.2064602037552572 0.9981663302093502 0.9528558977659324 1.0 15.661841064588732 -7.8342703381625505 6.633767604474037 0.9780568110400012 1.1502361213861498 0.6017707301923472 0.061805447833054944 0.16428596422200767 11.875053845156492 0.03820405964452036 0.01823695192595347 1.4646358555590424e-08 7.8342703381625505 0.17217931034614864 DGQVINETSQHHDDLE ddPTM_A459_Selumetinib_30min_R2 3 DGQVINETSQHHDDLE 16 0 P08670 P08670 VIM Vimentin 0 ;; 166.04 2.4041e-05 397614000.0 544940.0 467810.0 883140.0 1063230.0 1327990.0 727990.0 554020.0 665650.0 776290.0 959050.0 False True 514654.41636766033 503689.5227537673 826319.7338901276 918416.239825948 1161156.0238187695 828264.0144647505 579783.027769804 667586.93129571 931569.691354871 931359.7345888487 0.5525839235414831 0.5408109284176027 0.8872186580568772 0.9861025828343174 1.246732042084002 0.8893062301328605 0.6225124473796914 0.7167874093144236 1.0002254303661893 1.0 19.828978986008103 -5.2751758180868045 5.733576311295455 0.9121017745361124 0.5438612033121595 0.4637968141984933 0.15995045707435537 0.15280130836371397 19.654453632369083 0.04729775416890288 0.1096365554312344 5.306695665380391e-06 5.2751758180868045 -0.36824057122395293 DGRHPQGEQMYR ddPTM_A459_Selumetinib_30min_R1 2 DGRHPQGEQMYR 12 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 107.11 0.006863299999999999 8482700.0 1385.05 1957.04 3071.6 3621.1000000000004 2366.3 1793.52 1891.9 1320.1 677.89 1056.9099999999999 False True 1417.3189701618464 1727.9088469967865 2654.493591091077 2988.742861465514 2152.2685828041967 1775.4788171858677 1749.1924598225714 1285.0866597108757 1150.329818873325 1192.5746936752091 1.1884529981044902 1.4488894122613107 2.2258510139189767 2.5061263477384177 1.80472434491416 1.488777874125685 1.4667361877619667 1.0775733096855915 0.964576747246165 1.0 10.21986391300617 -7.424512028055041 1.3633928237178736 0.9810720032829093 1.856006853813981 0.49479618011283544 0.3514637018442444 0.4186185301194991 1.4916009805064192 0.27045954527899363 0.13716009616367794 3.762599313712904e-08 7.424512028055041 0.8749348505310716 DGRHPQGEQMYR ddPTM_A459_Selumetinib_30min_R2 2 DGRHPQGEQMYR 12 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 108.98 0.0062364 2199800.0 8799.0 15867.599999999999 13610.3 12030.8 13534.9 7856.2 1994.37 3969.9 3288.5 13141.7 False True 8309.98680518781 17084.593897624385 12734.6281157742 10392.184285712405 11834.524858458772 8938.320238516982 2087.1121567691835 3981.4517517476775 3946.2918883671045 12762.264974762804 0.651137303732581 1.3386803934418323 0.9978344863515014 0.8142899639102307 0.9273059979448299 0.7003709965427283 0.16353775453623773 0.31197062273984605 0.3092156365794661 1.0 13.639596772749195 -6.97246725985267 3.3195729571240293 0.3890795977876868 0.9628363031064541 0.4313828723201161 0.26555717369696874 0.20012273926678945 4.600087245151599 0.09916409558565016 0.08233730470005785 1.065449181631077e-07 6.97246725985267 0.5737567053187673 DGS(ph)FGEGLTMK ddPTM_A459_Selumetinib_30min_R1 3 DGSFGEGLTMK 11 0 Q9ULT0;Q9ULT0-4;G5E9G4 Q9ULT0 TTC7A Tetratricopeptide repeat protein 7A 1 DGS(1)FGEGLTMK;DGS(0.999)FGEGLT(0.001)MK;DGS(1)FGEGLTMK 190.78 1.987e-05 29597000.0 7074.0 8109.599999999999 7776.5 7704.9 7160.6 6818.1 6974.4 7558.2 4210.9 6930.0 True False 7238.810436392119 7160.124261949246 6720.494013256853 6359.38385388574 6512.924994306611 6749.516104339486 6448.3153928783495 7357.731983506358 7145.589748032398 7819.533003916319 0.9257343670992434 0.9156715955240785 0.8594495361667984 0.8132690086096854 0.8329045981447601 0.8631610226543033 0.8246420073486215 0.9409426342751321 0.9138128510300572 1.0 12.932866734515445 -8.38243621608022 1.2605396647194198 0.9943200312857363 0.8623733409059949 0.5230733254932683 0.03922467110709559 0.3655466102773296 1.2278643475671847 0.0400617528590144 0.01255363389257649 4.145374618150063e-09 8.38243621608022 -0.13194669037974138 DGS(ph)FGEGLTMK ddPTM_A459_Selumetinib_30min_R2 2 DGSFGEGLTMK 11 0 Q9ULT0;Q9ULT0-4;G5E9G4 Q9ULT0 TTC7A Tetratricopeptide repeat protein 7A 1 DGS(1)FGEGLTMK;DGS(1)FGEGLTMK 154.67 0.00053883 16415900.0 91075.0 75855.0 85759.0 76827.0 91544.0 70442.0 92952.0 84944.0 51081.0 76963.0 True False 86013.41610211153 81672.83458773224 80241.35930733924 66363.03006603272 80043.42430625642 80144.74609119073 97274.45218089376 85191.17297676382 61298.62732239013 74740.87821611109 1.150821587263214 1.0927465202051494 1.0735940120388159 0.8879080852401271 1.0709457289866622 1.0723013697999977 1.301489285416576 1.1398203367431141 0.820148609240942 1.0 16.189609895242747 -8.252622352051231 24.776491456458256 0.9100743000556941 1.095595529014541 0.3441417044811146 0.10409022796827914 624.1198323515837 1753835.7614179335 0.07819909760539225 0.028544854998922113 5.589560329339223e-09 8.252622352051231 0.18552122895884682 DGS(ph)GGASGTLQPSSGGGSSNSR ddPTM_A459_Selumetinib_30min_R1 1 DGSGGASGTLQPSSGGGSSNSR 22 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 DGS(0.969)GGAS(0.03)GT(0.001)LQPSSGGGSSNSR 85.22399999999998 0.0037005 0.0 464.07 372.19 505.87 543.25 585.54 361.04 374.2 356.46 168.64 329.04 True False 474.881928076971 328.61382177356325 437.1756325450068 448.3815855654747 532.5780103854837 357.40826539809143 345.9737927298517 347.0055228547374 286.1697630217254 371.2754891210138 1.279055423780447 0.8850943070644091 1.177496617350125 1.2076789303463256 1.4344550771351752 0.96264977320277 0.9318519613264445 0.9346308415787561 0.7707747249871671 1.0 8.536346264216526 -6.975204981304161 24.93069083240095 0.9100645996394399 1.1809358967296213 0.5023687409285198 0.13810029539414867 200.21743121936953 201312.32804852346 0.05032422257788999 0.044380112630411056 1.0587538892674819e-07 6.975204981304161 0.27087129709018143 DGSGGASGTLQPSS(ph)GGGSSNSR ddPTM_A459_Selumetinib_30min_R2 1 DGSGGASGTLQPSSGGGSSNSR 22 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 DGSGGASGTLQPS(0.032)S(0.968)GGGSSNSR 305.19 1.8034999999999992e-107 1772700.0 8998.3 7956.0 8854.8 10806.0 10614.0 7906.6 8146.2 9632.2 6879.2 9711.5 True False 8498.210509048922 8566.199617427945 8285.091808377283 9334.20415861026 9280.574429636072 8995.662381031329 8525.014441389072 9660.228107303446 8255.2322209077 9431.103761492717 0.9010833433672094 0.9082923732006657 0.8784859140459665 0.9897255289165517 0.984039054636292 0.9538292238667441 0.9039254213485365 1.0242945419332832 0.8753198384492267 1.0 13.203210910074244 -5.755813918366751 24.9976285492188 0.960812045454174 0.8971877196914846 0.33399171438086117 0.042453769092732664 157.7249309251217 700866.2793567331 0.011027564993661667 0.01843245715969037 1.7546321459231231e-06 5.755813918366751 -0.0636243257626894 DGSGGASGTLQPSSGGGSS(ph)NSR ddPTM_A459_Selumetinib_30min_R1 1 DGSGGASGTLQPSSGGGSSNSR 22 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 DGSGGAS(0.003)GT(0.022)LQPS(0.037)S(0.045)GGGS(0.253)S(0.543)NS(0.097)R 110.38 4.837e-05 2637500.0 1509.1 1365.0 1259.9 1257.0 1674.6 1533.8 1357.2 1314.1 1018.3 1430.1 True False 1544.2590938025655 1205.1851654287157 1088.8125001353187 1037.4885468123366 1523.1327256746433 1518.3713645789742 1254.825311312011 1279.2457992016218 1727.9807263106218 1613.6672653536398 0.9569873089444724 0.746861011129575 0.674744120744559 0.6429383362281741 0.9438951625140914 0.9409445163691902 0.7776233293280648 0.7927568629963324 1.0708407881918147 1.0 10.656127413394337 -6.277394505060641 24.953688048956938 0.904475339097549 0.7490140994243089 0.33296248295610553 0.11326270313182892 1039.1648696143864 1625242.0446664435 0.03635385098350358 0.04135381074638234 5.279654398587587e-07 6.277394505060641 -0.1554612396732401 DGSIS(ph)PVSSECSVVER ddPTM_A459_Selumetinib_30min_R1 2 DGSISPVSSECSVVER 16 0 H0YCZ0;H7BY22;H0YEM9;Q8NCP5-3;Q8NCP5-4;Q8NCP5-2;Q8NCP5 H0YCZ0 ZBTB44 Zinc finger and BTB domain-containing protein 44 1 DGS(0.083)IS(0.917)PVSSECSVVER;DGS(0.141)IS(0.845)PVS(0.014)SECSVVER 270.51 1.7068e-50 42030000.0 5590.299999999999 6640.5 7378.6 7559.1 6760.2 5645.2 6375.200000000001 5483.4 2941.56 5012.0 True False 5720.543113169758 5863.0271729153 6376.6266477486015 6239.0450868807775 6148.741103610249 5588.414413431497 5894.313531297031 5337.962419406573 4991.612476957945 5655.339021014226 1.0115296522300865 1.0367242619990318 1.127541005774225 1.1032132757554594 1.0872453589011428 0.9881661192487226 1.0422564428754524 0.9438801811123367 0.8826371784980542 1.0 12.465397796812729 -7.450582475761856 1.3340992481757772 0.934156270904696 1.0719729275279488 0.5464125103285127 0.04756598363079487 0.3382494436800956 1.1490430629664452 0.03450558857079621 0.017053974913809215 3.5433783249334496e-08 7.450582475761856 0.13781665662325282 DGSIS(ph)PVSSECSVVER ddPTM_A459_Selumetinib_30min_R2 1 DGSISPVSSECSVVER 16 0 H0YCZ0;H7BY22;H0YEM9;Q8NCP5-3;Q8NCP5-4;Q8NCP5-2;Q8NCP5 H0YCZ0 ZBTB44 Zinc finger and BTB domain-containing protein 44 1 DGS(0.236)IS(0.762)PVS(0.002)SECSVVER 127.05 0.0010702 16786000.0 19631.0 18440.0 19406.0 21394.0 15979.0 16089.0 15281.0 19022.0 12714.0 16955.0 True False 18539.98760911944 19854.288706054715 18157.439087655228 18480.100293291485 13971.57516592753 18305.11370859954 15991.596778727062 19077.350870738384 15257.155258841221 16465.465095619536 1.1259923422419331 1.205814022911308 1.102758955317079 1.1223551953116662 0.8485381423962643 1.1117277041551303 0.9712204718092936 1.1586281201260276 0.9266155052553132 1.0 14.007155643481926 -6.028096501075101 24.797497370991984 1.0119390562140789 1.1445520640734674 0.3786982651870803 0.08549860917490305 686.3255401970572 605738.5690634697 0.02403668311672057 0.03110628177791309 9.373537019756359e-07 6.028096501075101 0.13261300785938857 DGSISPVS(ph)SECSVVER ddPTM_A459_Selumetinib_30min_R2 1 DGSISPVSSECSVVER 16 0 H0YCZ0;H7BY22;H0YEM9;Q8NCP5-3;Q8NCP5-4;Q8NCP5-2;Q8NCP5 H0YCZ0 ZBTB44 Zinc finger and BTB domain-containing protein 44 1 DGS(0.003)IS(0.324)PVS(0.491)S(0.113)ECS(0.069)VVER 74.237 0.032716 16062000.0 23002.0 21194.0 24439.0 24743.0 19912.0 18862.0 20834.0 16953.0 17249.0 20283.0 True False 21723.64092430164 22819.51165054899 22866.621347171305 21372.960715944246 17410.47654446142 21460.069287811817 21802.822281787823 17002.33042327977 20699.281977328326 19697.3770884371 1.1028697286327533 1.1585050917233375 1.1608967653157556 1.0850663324352336 0.8838982198640979 1.0894886761552363 1.106889622100329 0.8631773838183057 1.0508648884769216 1.0 14.265715912102321 -6.010516097515382 18.35050201212367 1.00052146789868 1.1392745527177248 0.42390484486158353 0.07509401085859663 14.799381162606009 25828.978789974804 0.021761366773316387 0.03004002181319633 9.760766026029747e-07 6.010516097515382 0.1387530848190448 DGT(ph)SPEEEIEIER ddPTM_A459_Selumetinib_30min_R1 2 DGTSPEEEIEIER 13 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 DGT(0.5)S(0.5)PEEEIEIER;DGT(0.5)S(0.5)PEEEIEIER 233.52 4.5117e-13 35383000.0 2633.8 3125.6 3068.2 2862.1 2404.1 2828.3999999999996 2802.7 2377.0 1593.09 2345.7 True False 2695.162415517327 2759.653298947983 2651.5552924162125 2362.2879632709546 2186.6495794783277 2799.9488639817278 2591.2900825332836 2313.9542384158417 2703.357375310014 2646.7934440528875 1.0182745546590046 1.0426402200552074 1.001799100860713 0.89250937528911 0.826150444188056 1.0578645153715969 0.9790299610858131 0.8742481373509118 1.0213707387647573 1.0 11.370029895865581 -5.560839235202871 8.479695168215597 0.9454579271193321 1.028479587187457 0.19515195526648588 0.06701862031978802 0.3773263574863224 76.21109280685896 0.01860796205876334 0.032469092680246545 2.748911542085191e-06 5.560839235202871 0.08302166006812495 DGT(ph)SPEEEIEIER ddPTM_A459_Selumetinib_30min_R2 1 DGTSPEEEIEIER 13 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 DGT(0.906)S(0.094)PEEEIEIER 175.6 0.00023136 24611000.0 115620.0 110370.0 127800.0 121740.0 122440.0 95472.0 100960.0 104050.0 81954.0 109440.0 True False 109194.30326353172 118835.02410451538 119577.48713811935 105158.80198678652 107057.99257251203 108622.40139147334 105654.84004844485 104352.76827359514 98347.08998608409 106280.18284073149 1.0274192266602256 1.1181296543552077 1.1251155572183653 0.9894488245694361 1.0073184831921689 1.0220381494285895 0.9941160922424855 0.9818647793443795 0.9253568008390076 1.0 16.697513089342394 -5.772401079606006 24.93348459292983 0.9902402686036758 1.0930122948098164 0.6499759910037848 0.03414328733623181 122.50887810568491 278658.6764609333 0.009911610729269462 0.014866088933996689 1.6888804964235216e-06 5.772401079606006 0.10277202620614068 DGTAPPPQSPGSPGTGQDEEWS(ph)DEESPRK ddPTM_A459_Selumetinib_30min_R1 2 DGTAPPPQSPGSPGTGQDEEWSDEESPRK 29 1 A0A0C4DGG1;Q9UKS6 A0A0C4DGG1 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 1 DGTAPPPQSPGSPGT(0.002)GQDEEWS(0.997)DEES(0.002)PRK;DGTAPPPQS(0.003)PGS(0.015)PGT(0.137)GQDEEWS(0.836)DEES(0.009)PRK 112.86 1.7278e-11 24511000.0 2478.88 2711.98 2907.7799999999997 3054.19 2820.49 2379.37 2705.36 2633.05 1534.69 1932.0 True False 2536.6330809391707 2394.460120834704 2512.919447292228 2520.8330507468354 2565.3771774979523 2355.4356980951075 2501.2925171021693 2563.212960648224 2604.2568406772543 2179.9910192736415 1.1635979499513533 1.0983807271061705 1.1527200915394211 1.156350199821814 1.1767833696639352 1.080479542012023 1.1473866153520134 1.1757906055513336 1.1946181510165006 1.0 11.090106476326643 DGTAPPPQSPGSPGTGQDEEWS(ph)DEESPRK ddPTM_A459_Selumetinib_30min_R2 4 DGTAPPPQSPGSPGTGQDEEWSDEESPRK 29 1 A0A0C4DGG1;Q9UKS6 A0A0C4DGG1 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 1 DGTAPPPQSPGSPGT(0.036)GQDEEWS(0.963)DEES(0.001)PRK;DGTAPPPQSPGSPGT(0.01)GQDEEWS(0.987)DEES(0.003)PRK;DGTAPPPQSPGSPGT(0.002)GQDEEWS(0.993)DEES(0.005)PRK;DGTAPPPQSPGSPGT(0.01)GQDEEWS(0.984)DEES(0.006)PRK 96.133 8.7714e-08 88950000.0 238073.0 202380.0 235712.0 240022.0 235600.0 198000.0 225339.0 209950.0 159471.0 210888.0 True False 224841.85574172973 217901.8952457345 220546.54654382105 207330.58953895557 206001.8217092764 225272.70273495617 235817.71000075742 210560.9197409065 191369.65599202985 204799.11548717256 1.0978653653209383 1.0639786931080892 1.07689208529631 1.0123607665285135 1.005872614338411 1.0999691194909773 1.1514586351596214 1.0281339313406108 0.9344261841014452 1.0 17.64384995889081 -8.005071723974034 24.980653094905733 0.9719020602300582 1.0701377759315984 0.49411045199835635 0.04244701960657971 188.03976901938094 926179.3998233594 0.026078227231439766 0.011964739620222164 9.883898480467761e-09 8.005071723974034 0.09823571570154022 DGTDT(ph)SQSGEDGGCWQR ddPTM_A459_Selumetinib_30min_R2 1 DGTDTSQSGEDGGCWQR 17 0 Q9NPI1-2;Q9NPI1 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 1 DGT(0.011)DT(0.494)S(0.494)QS(0.001)GEDGGCWQR 180.56 1.802e-07 5359700.0 9301.9 8393.8 8634.6 10595.0 8904.4 9753.5 6232.9 8298.1 8672.5 5997.8 True False 8784.93763645602 9037.577469679067 8079.059236641656 9151.942722605554 7785.749665653994 11096.956091542399 6522.742200257041 8322.246097175592 10407.24232989622 5824.627929844106 1.508240138643696 1.5516145543602051 1.3870515565889354 1.5712493283413045 1.3366947656452928 1.9051785324662627 1.1198555991595536 1.4288030407117067 1.7867651728571041 1.0 12.507950179765837 -11.099029937502731 2.809066665356011 0.9676430481726828 1.5025531017231681 0.3458114008971286 0.21042536507193588 38451113.85524823 38576654.16168931 9277110.545025973 0.049157167690029535 7.961044701408654e-12 11.099029937502731 0.5349100535504854 DGTDTS(ph)QSGEDGGCWQR ddPTM_A459_Selumetinib_30min_R2 1 DGTDTSQSGEDGGCWQR 17 0 Q9NPI1-2;Q9NPI1 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 1 DGTDT(0.09)S(0.82)QS(0.09)GEDGGCWQR 222.96 3.3519999999999994e-12 5416100.0 16342.0 13750.0 16072.0 19425.0 13966.0 12354.0 15064.0 11948.0 12006.0 15131.0 True False 15433.77706220925 14804.58078678158 15037.945017870494 16779.28149000594 12211.466222375871 14055.651361553771 15764.505848749723 11982.766701902126 14407.535475668372 14694.128714940673 1.0503363187853745 1.0075167486268581 1.0233982095570073 1.1419038049493284 0.8310439127948782 0.9565488117211256 1.0728438653678536 0.8154799059108764 0.9804960712654641 1.0 13.842952196796587 -6.255736459210491 24.99983025925122 0.940705514634551 1.0500271514987645 0.33173383841852033 0.07840628882240744 587.9262983611335 2577285.500477209 0.02322493959327659 0.02914395444328326 5.549623758953623e-07 6.255736459210491 0.10932163686421348 DGTGVVEFVR ddPTM_A459_Selumetinib_30min_R2 2 DGTGVVEFVR 10 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 ; 152.06 0.0089769 9896200.0 39962.0 36569.0 45039.0 52512.0 53153.0 36502.0 39394.0 38137.0 28289.0 42230.0 False True 37741.07202056091 39373.72471213205 42141.239774755464 45359.77501174736 46475.44494615097 41529.81916783519 41225.899057730094 38247.9723560798 33947.59046070152 41010.71017328296 0.9202735544225688 0.9600839523569784 1.0275666916445891 1.1060470501507595 1.13325140554206 1.0126578884481354 1.0052471386995712 0.9326337484640053 0.8277737770758523 1.0 15.323713106257797 -7.748104875012864 2.985744699787934 0.9045682920395729 1.0306309852270585 0.31680473332206294 0.06991355303902937 0.3050682462742392 5.524721186036134 0.04524891800402561 0.021152199940320082 1.7860562194121697e-08 7.748104875012864 0.12606269318748564 DGTS(ph)PEEEIEIER ddPTM_A459_Selumetinib_30min_R2 1 DGTSPEEEIEIER 13 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 DGT(0.014)S(0.986)PEEEIEIER 126.56 0.0020151 22508000.0 51832.0 46035.0 44754.0 48126.0 49700.0 44365.0 47392.0 41583.0 43463.0 50749.0 True False 48951.38493993576 49565.736474144716 41874.5763644709 41571.15577801936 43456.241676362624 50475.87604462791 49595.82190546643 41703.999645563774 52156.81445768573 49283.74450826281 0.9932562030007414 1.0057218047998489 0.8496630437131313 0.8435064379300486 0.881756086311113 1.0241891428555157 1.0063322582388459 0.8462019284791107 1.0582965027939633 1.0 15.588824253647829 -6.7533956642473605 24.99767192289488 0.9785996072666202 0.9122556683283385 0.19556194413628347 0.07215106184873687 360.32494565160835 1119790.7554414542 0.025501996318491447 0.02506842065840977 1.7644296035687055e-07 6.7533956642473605 -0.06634393893828172 DGVDNRS(ph)MRRSLSS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 DGVDNRSMRRSLSSSK 16 3 A0A0A0MS79;O14513 A0A0A0MS79 NCKAP5 Nck-associated protein 5 2 DGVDNRS(0.992)MRRS(0.001)LS(0.008)S(0.581)S(0.417)K 104.16 0.011774 4307700.0 6268.2 6696.8 10347.0 13892.0 12104.0 26809.0 5522.6 6068.4 28956.0 17345.0 True False 5919.83853759271 7210.423026394099 9681.285284961801 11999.88563496333 10583.387308867073 30501.69640212847 5779.411842824294 6086.058039322299 34748.00909823865 16844.204782277848 0.3514466022059468 0.42806550499672985 0.5747546654827951 0.7124044019928248 0.6283102969635043 1.8108124898968199 0.34310980646025735 0.36131465498006604 2.062905880531551 1.0 14.039964699742878 -5.366620544049659 0.4528897640829515 1.1008106084972868 6.873974130179861e-08 0.21928154231281893 0.5210762557874912 5.379254264768256 1.2632963182626786 0.4117169612872618 3.0141029889016218 4.299118894640997e-06 5.366620544049659 -1.1008105397575456 DGVLT(ph)LANNVTPAK ddPTM_A459_Selumetinib_30min_R2 1 DGVLTLANNVTPAK 14 0 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DGVLT(0.684)LANNVT(0.316)PAK 168.93 0.00043764 16725000.0 43206.0 30440.0 36379.0 43331.0 47472.0 38353.0 53040.0 51323.0 44075.0 36795.0 True False 40804.783487321816 32774.65011997317 34038.41474646036 37429.24304985574 41508.142954935334 43635.77761613015 55506.46509676611 51472.34143301995 52891.23155839446 35732.632745108865 1.1419473000602576 0.9172190124854266 0.9525862532790726 1.0474806968982464 1.1616312531747897 1.2211744353514808 1.5533830236554265 1.44048555840223 1.4801940829740368 1.0 15.124954593735254 -6.714914829016207 1.7484819733376484 1.4011420120490927 1.0038929871750402 0.5000889802858162 0.15332407341340137 0.25266128891338935 1.5965161581598597 0.06072001889107433 0.057408402155299416 1.9279029637969836e-07 6.714914829016207 -0.39724902487405256 DGVLT(ph)LANNVTPAKDVPPLSETEATPVPIK ddPTM_A459_Selumetinib_30min_R2 1 DGVLTLANNVTPAKDVPPLSETEATPVPIK 30 1 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DGVLT(0.578)LANNVT(0.421)PAKDVPPLS(0.001)ET(0.001)EATPVPIK 52.402 0.016211 4788500.0 13220.0 12617.0 15225.0 16037.0 13313.0 15318.0 15310.0 17089.0 14641.0 13119.0 True False 12485.285323853039 13584.683329950776 14245.440075726636 13852.73293463193 11640.501920269942 17427.915457040694 16021.945336189467 17138.726160763756 17569.609103719864 12740.220382744476 0.9799897449782954 1.0662832291621935 1.118147068713258 1.0873228655757208 0.913681362689455 1.3679445828617922 1.2575877696660416 1.3452456586996466 1.3790663407609791 1.0 13.637102613371496 -6.768803889353401 24.99913650405992 1.2907729215266595 1.04266810440187 0.5120479409761658 0.11453544418820731 130.13420674440937 441743.13585642347 0.038101496178195915 0.03426419188768192 1.7029273111293523e-07 6.768803889353401 -0.2481048171247895 DGVLTLANNVT(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 DGVLTLANNVTPAK 14 0 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DGVLT(0.002)LANNVT(0.998)PAK;DGVLTLANNVT(1)PAK 153.48 0.00018006 15248000.0 6059.9 8553.8 5106.5 5219.5 5067.0 4777.8 6796.700000000001 6787.0 3430.2 6643.299999999999 True False 6201.083879487223 7552.3171194462675 4413.065347996672 4308.0123071495545 4608.690744651508 4729.739669895307 6284.019446945437 6606.986712717005 5820.798868104382 7496.032266221826 0.8272488243454045 1.0075086193902965 0.5887201643838387 0.5747056781708455 0.6148173568327494 0.6309657565387196 0.8383127531697151 0.8813978486310704 0.7765173176126414 1.0 12.871911447666928 -8.293548559553603 0.8925281005392005 0.9759715316478597 0.7141035918968789 0.26920256745450943 0.1335233225006568 0.8369109397493217 1.4280783507470936 0.14136090106995972 0.05126694019180248 5.086879387924376e-09 8.293548559553603 -0.26186793975098077 DGVLTLANNVT(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 DGVLTLANNVTPAK 14 0 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DGVLT(0.001)LANNVT(0.999)PAK 156.29 0.00075295 15516000.0 56151.0 41519.0 51777.0 56513.0 56480.0 54179.0 63680.0 59611.0 63223.0 45586.0 True False 53030.352210262616 44703.37379537341 48445.72419053513 48815.83190963735 49384.477462393595 61641.66546200595 66641.24617952616 59784.45814086771 75869.36659821603 44269.81373334782 1.197889662009479 1.0097935822508102 1.094328620453211 1.102688893241606 1.1155338886188484 1.3924085118879133 1.5053428184931859 1.3504565097330177 1.7137945746779755 1.0 15.434035682812635 -6.770466660211407 4.580152414345871 1.425081835548406 1.0955744568952814 0.4091410033420423 0.17146337692166855 0.17027015761060835 8.814541195286388 0.056227647241801626 0.052177028411340684 1.6964198275102332e-07 6.770466660211407 -0.3295073786531246 DGVLTLANNVT(ph)PAKDVPPLSETEATPVPIK ddPTM_A459_Selumetinib_30min_R2 1 DGVLTLANNVTPAKDVPPLSETEATPVPIK 30 1 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DGVLT(0.077)LANNVT(0.923)PAKDVPPLSETEATPVPIK 55.158 0.007494199999999999 5438800.0 11792.0 10412.0 14400.0 14155.0 12945.0 12510.0 14176.0 14659.0 15209.0 10568.0 True False 11136.647847116117 11210.56692014326 13473.519677534548 12227.064581263015 11318.733370231676 14233.13894552677 14835.212089211094 14701.65526307191 18251.22497496588 10262.874381038473 1.0851392537447417 1.0923418239295346 1.3128407478540334 1.1913879218724093 1.1028814102162248 1.386856977595253 1.4455221352626513 1.4325085465563585 1.7783736112649453 1.0 13.325147230815961 -6.868691251467877 4.778206366421712 1.4455821047148991 1.1644271570878875 0.3065271472420825 0.186629224246615 0.2441558347788372 9.229745079356917 0.06448443125306182 0.05694691879365758 1.3530341200610088e-07 6.868691251467877 -0.28115494762701165 DGVLTLANNVT(ph)PAKDVPPLSETEATPVPIKDMEIAQTQK ddPTM_A459_Selumetinib_30min_R1 1 DGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQK 39 2 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DGVLT(0.001)LANNVT(0.998)PAKDVPPLSETEATPVPIKDMEIAQTQK 100.33 1.7734e-14 9655500.0 2398.5 2677.2 4154.6 4432.5 3736.4 2903.9 2732.8 2399.8 1427.0 2817.1 True False 2454.3803833314264 2363.752179403488 3590.42813958425 3658.4470833298988 3398.443279714997 2874.6894025302418 2526.6626958100987 2336.149508351005 2421.514776043657 3178.7022258777283 0.7721328419347941 0.7436217712248243 1.129526418157282 1.1509247558788553 1.0691291722918752 0.9043594518314655 0.7948724090103837 0.734938142155146 0.7617935257760765 1.0 11.634222158838272 -7.077627691421908 3.9884052745341885 0.8023730349904826 0.9797089469206124 0.18906955369500678 0.14297981956427452 0.3800062892571506 11.36520660129553 0.06232272848439307 0.04850187687050885 8.363196645905011e-08 7.077627691421908 0.17733591193012976 DGWNQNHFIT(ph)PVSTLER ddPTM_A459_Selumetinib_30min_R1 1 DGWNQNHFITPVSTLER 17 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 DGWNQNHFIT(0.828)PVS(0.005)T(0.167)LER 96.561 0.0139 4675500.0 678.49 789.65 794.33 621.38 672.22 794.35 857.71 665.79 370.99 619.96 True False 694.2974968882797 697.1974109016747 686.4643489423667 512.8676477472152 611.4178196900804 786.3595602120931 793.0122441537175 648.1310864092899 629.5429339624645 699.5379049217837 0.9925087575717717 0.9966542284504645 0.9813111542813697 0.7331520481432091 0.8740310073096665 1.124112867479307 1.1336229796473791 0.9265131765543975 0.8999411319002858 1.0 9.450258422663078 -6.73659904838145 24.992797928835547 1.0195442421558114 0.9135604925378672 0.20525670327496115 0.09956284293696788 410.8085268766054 413329.03097272385 0.036606100321076376 0.03659128372675718 1.8340068423789104e-07 6.73659904838145 -0.10598374961794421 DGWNQNHFITPVS(ph)TLER ddPTM_A459_Selumetinib_30min_R1 1 DGWNQNHFITPVSTLER 17 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 DGWNQNHFIT(0.106)PVS(0.642)T(0.252)LER 63.674 0.03171 10492000.0 2985.9 3470.6 2540.2 2974.3 3283.5 2903.2 3227.1 2887.3 1686.5 3091.0 True False 3055.465660449993 3064.2605385618317 2195.254792319818 2454.8943395258 2986.5080047490087 2873.996443894691 2983.677248846884 2810.719424727832 2861.867322913544 3487.7599588896596 0.8760538845748751 0.8785755254605737 0.6294168228878586 0.703859889574317 0.8562825538314207 0.8240235789648889 0.8554709280499763 0.8058809831691038 0.8205459540353887 1.0 11.768085036349092 -6.294530751732751 24.412074495020235 0.8485993896439828 0.7694078910299862 0.195939136749113 0.08569084300713384 940.1386124683878 693553.5966511462 0.027830298648337463 0.0315587879047939 5.075387997048456e-07 6.294530751732751 -0.07919149861399666 DGWNQNHFITPVS(ph)TLER ddPTM_A459_Selumetinib_30min_R2 1 DGWNQNHFITPVSTLER 17 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 DGWNQNHFIT(0.026)PVS(0.8)T(0.174)LER 121.25 0.00094932 10891000.0 71848.0 47353.0 52993.0 59646.0 64722.0 57892.0 63591.0 62019.0 52620.0 57342.0 True False 67854.97579033225 50984.82283610677 49583.48807441585 51522.111904910926 56591.04373797874 65866.0975087478 66548.10750317606 62199.46502220187 63145.47032564301 55686.38746759161 1.218519980844915 0.9155706655559034 0.8904059022193256 0.9252191468677294 1.0162455550005578 1.1828042813350137 1.1950516190676896 1.1169599582734784 1.1339480472205608 1.0 15.765037083539402 -6.627549446402128 5.15904537882759 1.1366855759161714 0.9748963482952295 0.30722218218418695 0.09864484789470543 0.22998993759023373 9.639686272966275 0.03318801284140603 0.03311397500644346 2.3574937692921885e-07 6.627549446402128 -0.16178922762094183 DGWNQNHFITPVST(ph)LER ddPTM_A459_Selumetinib_30min_R2 1 DGWNQNHFITPVSTLER 17 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 DGWNQNHFIT(0.012)PVS(0.25)T(0.738)LER 95.591 0.008585500000000001 12909000.0 64776.0 53908.0 69903.0 73160.0 67926.0 51521.0 63968.0 64584.0 54972.0 59903.0 True False 61176.00923887323 58042.57025845974 65405.517084631676 63195.48179196054 59392.52861385533 58617.55008892764 66942.63875018724 64771.92874754321 65967.9360460138 58173.44474331448 1.0516140054763357 0.9977502710139959 1.1243191351866495 1.0863286860663897 1.0209560199833438 1.0076341593242886 1.150742216582946 1.1134277681740181 1.1339871024845076 1.0 15.828073115500649 -7.261671297204004 24.999999671711034 1.1089915845320022 1.0497800435159497 0.18414757103490786 0.051455008793979885 33.33893489991355 3593552.195271797 0.02054068926711451 0.01486438801115894 5.474301374818114e-08 7.261671297204004 -0.05921154101605253 DGWQVEEADDWLR ddPTM_A459_Selumetinib_30min_R2 2 DGWQVEEADDWLR 13 0 E9PK47;P06737-2;P06737 E9PK47 PYGL Alpha-1,4 glucan phosphorylase;Glycogen phosphorylase, liver form 0 ; 190.85 0.0023121 4266000.0 17526.0 15194.599999999999 16133.7 17521.7 16476.7 12263.2 13904.4 15034.7 11662.8 13137.4 False True 16551.975082136792 16359.976961660454 15095.675307044388 15135.214233381572 14406.749642433088 13952.3444857541 14550.982151045917 15078.448487871425 13995.685885859166 12758.08912693553 1.297371018297044 1.2823218899702176 1.1832238477762023 1.1863229738242957 1.1292247215938334 1.0936076983736691 1.1405299027363853 1.181873581368626 1.0970048685669358 1.0 13.6391246417606 -1.5228787452803376 0.19226296120846406 1.040748450285154 2.243803422921539 0.8000863062374037 0.037632124521970935 26.602721730885257 0.313366602817094 0.0817610178133964 9.52775394313062 0.029999999999999995 1.5228787452803376 1.2030549726363848 DGWS(ph)LDR ddPTM_A459_Selumetinib_30min_R2 2 DGWSLDR 7 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 DGWS(1)LDR;DGWS(1)LDR 96.665 0.022999 6737800.0 38702.0 24515.0 37322.0 36539.0 44558.0 38045.0 33263.0 42678.0 30195.0 32652.0 True False 36551.097776381255 26395.221671850944 34920.743153121126 31562.32516670926 38960.2256864259 43285.353411875774 34809.79540938408 42802.18591427677 36234.84371879116 31709.251919915598 1.1526950515481775 0.83241388786195 1.1012793124642746 0.9953664389946059 1.2286706032934254 1.365070154325829 1.0977804048263002 1.3498327246059705 1.1427214937238295 1.0 14.952616221539968 -6.262626328002596 24.905526896481486 1.2182454773113014 1.0127826560979096 0.301911400179697 0.12925615036433802 106.18294179007094 2228011.808613971 0.03680398627724204 0.044064495250944954 5.46227639542285e-07 6.262626328002596 -0.20546282121339177 DGWS(ph)LDRDR ddPTM_A459_Selumetinib_30min_R1 2 DGWSLDRDR 9 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 DGWS(1)LDRDR;DGWS(1)LDRDR 155.53 0.00017214 6905600.0 10218.7 10874.599999999999 8726.9 8861.6 9258.4 8058.1 10552.2 9400.0 5349.5 8751.1 True False 10456.775827871099 9601.396776535617 7541.83491343037 7314.087912833896 8420.979354703279 7977.0428301694055 9756.239058375048 9150.68146449681 9077.710787978665 9874.388927932481 1.0589795382974203 0.9723535143906851 0.7637773809066982 0.7407129662620382 0.8528101755119423 0.8078517960340919 0.9880347158270003 0.9267086329374307 0.9193187400487955 1.0 13.269475755075211 -7.267719325371956 24.920584883371507 0.9524079082598841 0.859959552231541 0.1937626502140718 0.09152490105281677 954.7344978824212 3788635.73886604 0.041626151259847706 0.02882225136980769 5.398594086315688e-08 7.267719325371956 -0.09244835602834311 DGWS(ph)LDRDR ddPTM_A459_Selumetinib_30min_R2 2 DGWSLDRDR 9 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 DGWS(1)LDRDR;DGWS(1)LDRDR 131.42 0.017128 12833200.0 85491.0 63806.0 99957.0 96508.0 108141.0 94227.0 76288.0 87006.0 60264.0 92437.0 True False 80739.7524675886 68699.71503137345 93525.87544495286 83363.44391441427 94555.36078719392 107205.91394245821 79835.54316180422 87259.17305538121 72318.4839168482 89768.10362983108 0.8994258450699604 0.765302064468962 1.0418608800138787 0.9286532804365886 1.0533291554994146 1.1942539678072506 0.8893531213605125 0.972050979434792 0.805614477666384 1.0 16.453915297684894 -5.264610751149897 24.954712608919586 0.9890352898020284 0.8323639532887891 0.26191544948683354 0.1027949235827058 335.535123185757 2640261.8418464623 0.027484739596957103 0.061371551610919096 5.437374534046996e-06 5.264610751149897 -0.15667133651323928 DGYDYDGYR ddPTM_A459_Selumetinib_30min_R1 1 DGYDYDGYR 9 0 J3KTL2;Q07955;Q07955-3;Q07955-2 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 151.44 0.016802 25243000.0 3339.3 3931.5 4134.9 4403.9 3516.0 3547.8 4014.2 3489.4 2045.6 3196.6 False True 3417.099192853296 3471.1981522952346 3573.4032913798947 3634.8415364414086 3197.978420800219 3512.112353144665 3711.405662149041 3396.8497768313996 3471.233795287249 3606.914747520766 0.9473745380874496 0.9623732179090684 0.9907091077869512 1.0077425697238445 0.8866243436993814 0.9737164859687177 1.028969610302017 0.9417604835729051 0.9623830997594889 1.0 11.816549608873645 -6.990954593018426 24.99210250549624 0.9816990238512855 0.960281863475037 0.08952805230980665 0.03648611360521532 618.2425127902799 1708168.4991379345 0.013366518627595874 0.011771436348525394 1.0210462320219552e-07 6.990954593018426 -0.021417160376248523 DGYGGS(ph)RDSYSSSR ddPTM_A459_Selumetinib_30min_R1 1 DGYGGSRDSYSSSR 14 1 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DGYGGS(1)RDSYSSSR 174.21 0.00042733 4604300.0 1589.7 1595.5 2031.0 2252.3 1828.8 1493.5 1505.4 1269.4 821.74 1048.4 True False 1626.736916982266 1408.6981182721731 1755.2013554844298 1858.9780859072594 1663.3853629008643 1478.476745989503 1391.846465995507 1235.731388407685 1394.432762485015 1182.9723522807894 1.3751267422656932 1.1908123766005019 1.4837213668606657 1.5714467733105681 1.4061067105193379 1.2497982249027006 1.176567198136123 1.0445987059842736 1.1787534677344966 1.0 10.208200640931924 -7.1184677332456605 1.9045626175848238 1.0898363124679733 1.4063681324683277 0.6694824078604139 0.10179428467521827 0.23399206442227138 1.67483895283061 0.05324457792501881 0.037512755225686166 7.612586961020924e-08 7.1184677332456605 0.3165318200003544 DGYGGSRDS(ph)YSSSR ddPTM_A459_Selumetinib_30min_R1 1 DGYGGSRDSYSSSR 14 1 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DGYGGS(0.011)RDS(0.905)YS(0.082)S(0.001)SR 151.49 0.0019024 45268000.0 4219.9 4527.0 5177.7 5768.8 5908.7 4890.6 5179.4 4748.2 2940.9 3705.3 True False 4318.2154595039765 3996.976735454795 4474.596779070278 4761.3873737875965 5374.259128265713 4841.405004309513 4788.713688041135 4622.262311672737 4990.492505162436 4180.911347678374 1.0328407135209519 0.9560060960570913 1.0702443575023386 1.1388395920979182 1.2854276690774598 1.1579783931553358 1.1453755628423619 1.1055633394952136 1.193637484787525 1.0 12.029601737367088 -5.591063990346522 3.0156797090228773 1.1575617067545332 0.9957542589417071 0.4291847915736413 0.06986166983147936 0.21325624408452376 3.8991857333442566 0.01932497228660667 0.03868169449948041 2.564106205023411e-06 5.591063990346522 -0.16180744781282608 DGYGGSRDS(ph)YSSSR ddPTM_A459_Selumetinib_30min_R2 3 DGYGGSRDSYSSSR 14 1 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DGYGGSRDS(0.786)Y(0.004)S(0.146)S(0.039)S(0.026)R;DGYGGS(0.002)RDS(0.998)YSSSR;DGYGGSRDS(0.999)YSSSR 168.47 0.00092831 43163000.0 81484.0 83798.0 83208.0 83424.0 94312.0 75355.0 75908.0 70133.0 64482.0 79136.0 True False 76955.4454862966 90225.03714696143 77854.48787002043 72061.50728557285 82463.68340002238 85734.46724541727 79437.87240884847 70337.0754188568 77380.20177761531 76851.13805997936 1.0013572658642456 1.1740234357563353 1.0130557573429555 0.9376765146839025 1.0730313887565677 1.1155913810736908 1.0336590246308424 0.9152379157217088 1.006884266531265 1.0 16.229779003959074 -7.573865085334419 9.766386738907178 0.9712730264442808 1.0537934715705262 0.22765119376891596 0.06463020970651193 0.5901030843299733 107.8282123573758 0.03145061478776936 0.018139714228418306 2.667687259522763e-08 7.573865085334419 0.08252044512624535 DHALLEEQSK ddPTM_A459_Selumetinib_30min_R2 2 DHALLEEQSK 10 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ; 123.96 0.0056081 13974700.0 184106.0 188844.0 207710.0 215700.0 212450.0 132515.0 149597.0 160305.0 124868.0 165278.0 False True 173874.1255547116 203327.7275708346 194346.16473754874 186321.28789674595 185760.13167290244 150767.73839859964 156553.5569208319 160771.46101007846 149845.08910342824 160505.9946961841 1.0832874241478117 1.266792109264867 1.2108343062539157 1.1608369410091297 1.157340771131452 0.9393277720497752 0.9753751392100114 1.0016539339505472 0.9335793930131053 1.0 17.292267655628308 -6.706030825999099 5.51799190498501 0.9703802396671545 1.1844433570769388 0.8223989854073488 0.04781749428878024 0.07738805127929055 4.896849637078619 0.015919498630999385 0.015672384033246407 1.967746615106567e-07 6.706030825999099 0.21406311740978434 DHANYEEDENGDIT(ph)PIK ddPTM_A459_Selumetinib_30min_R1 2 DHANYEEDENGDITPIK 17 0 H3BSB3;H3BNT4;Q99547 H3BSB3 MPHOSPH6 M-phase phosphoprotein 6 1 DHANYEEDENGDIT(1)PIK;DHANYEEDENGDIT(1)PIK 206.64 1.3545e-08 41672300.0 11894.4 14116.2 11324.3 10711.099999999999 10459.9 10398.6 11325.8 11329.5 6713.39 10846.0 True False 12171.516377526494 12463.468741556664 9786.52225992729 8840.607457248696 9513.803891845335 10293.99952517338 10471.48578754611 11029.00485659751 11392.132503394347 12238.18974898649 0.9945520233933685 1.0184078689079674 0.7996707405797303 0.7223786882353932 0.7773865324022472 0.8411374342374355 0.8556400907587913 0.9011957718265384 0.9308674515638876 1.0 13.579102552506077 -9.77167974070891 19.430765470818365 0.9999999999999958 0.8658684391960053 0.15681808151111598 0.08877914618817966 0.0 0.0 0.09676232671509674 0.023468311389815855 1.6916879635517962e-10 9.77167974070891 -0.13413156080399047 DHANYEEDENGDIT(ph)PIK ddPTM_A459_Selumetinib_30min_R2 3 DHANYEEDENGDITPIK 17 0 H3BSB3;H3BNT4;Q99547 H3BSB3 MPHOSPH6 M-phase phosphoprotein 6 1 DHANYEEDENGDIT(1)PIK;DHANYEEDENGDIT(1)PIK;DHANYEEDENGDIT(1)PIK 143.4 0.00067302 85953000.0 514037.0 443978.0 496200.0 494743.0 515966.0 477995.0 476941.0 453211.0 443928.0 524006.0 True False 485468.88139314967 478029.6849857244 464275.032221711 427358.14992072195 451145.73828543536 543834.4724434103 499119.7015406626 454529.76897687966 532726.0043846841 508876.58524890663 0.9540012165340491 0.9393823548629299 0.9123529077185194 0.8398070618865051 0.8865523613446796 1.0686961990546386 0.9808266208525361 0.8932023640949321 1.046866803911035 1.0 18.95695628508296 -6.7309095869160736 24.994848915454174 0.9901753812621995 0.904879414217083 0.43121369374490814 0.05215045195036253 223.24183083589114 182768.3757474821 0.018024398080372563 0.018022303873247908 1.8581912601804822e-07 6.7309095869160736 -0.08529596704511655 DHAPSIPT(ph)SPFGDSLESSTELR ddPTM_A459_Selumetinib_30min_R1 1 DHAPSIPTSPFGDSLESSTELR 22 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 DHAPSIPT(0.972)S(0.028)PFGDSLESSTELR 162.73 2.4586e-09 19930000.0 3323.1 4624.4 2936.1 3166.2 3247.0 3403.1 3987.2 3591.8 1539.2 3023.3 True False 3400.5217643730102 4082.9730981747675 2537.3937468428526 2613.2826069349408 2953.3094233044117 3368.8679037675765 3686.4422938868615 3496.53379618932 2611.9099812798877 3411.3700044358156 0.9968199755380684 1.1968719584406453 0.7438049063993267 0.7660507665650108 0.8657253301354628 0.9875410463793216 1.0806339649740042 1.0249646891550215 0.7656483987030467 1.0 11.736135525868132 -6.784842830203125 23.94983350186017 0.9801227287633029 0.9119192367261647 0.038775964875008784 0.14094069703424023 564.4612343231641 577633.1185705458 0.05395569983231136 0.04761955008501432 1.641183604886432e-07 6.784842830203125 -0.06820349203713816 DHAPSIPT(ph)SPFGDSLESSTELRR ddPTM_A459_Selumetinib_30min_R2 3 DHAPSIPTSPFGDSLESSTELRR 23 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 DHAPSIPT(0.5)S(0.5)PFGDSLESSTELRR;DHAPSIPT(0.5)S(0.5)PFGDSLESSTELRR;DHAPSIPT(0.5)S(0.5)PFGDSLESSTELRR 98.299 7.5427e-05 47338000.0 106809.0 125331.0 137512.0 149670.0 142483.0 86592.0 93116.0 101291.0 96963.0 148508.0 True False 100872.98337030396 134943.48469731785 128664.62763174516 129284.6878048488 124583.01172581848 98519.26199608739 97446.0785058536 101585.74004037231 116358.30937258294 144220.18816987722 0.6994373301710403 0.9356768037105019 0.8921402007893018 0.8964396000687791 0.8638389209357564 0.6831169980172358 0.6756757132439162 0.7043794723157225 0.8068101342062061 1.0 17.137913603883533 -6.736269269582912 23.19681410370306 0.7493751751575235 0.8659365512250957 0.11130716348989467 0.10590803291585868 151.78364895074174 139882.80619411726 0.03358773352446821 0.03356867582467643 1.8354000128845876e-07 6.736269269582912 0.11656137606757222 DHAPSIPTS(ph)PFGDSLESSTELR ddPTM_A459_Selumetinib_30min_R1 1 DHAPSIPTSPFGDSLESSTELR 22 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 DHAPSIPT(0.153)S(0.846)PFGDS(0.001)LESSTELR 95.366 0.00014331 3979100.0 1418.4 1697.6 1496.1 1513.5 1500.2 1599.7 1600.1 1634.6 878.49 1654.1 True False 1451.4459602740435 1498.8442028071706 1292.9378374890475 1249.195636913661 1364.5071748818227 1583.6084704113869 1479.403168752099 1591.2450980709027 1490.7333676290073 1866.4198472984096 0.7776631621095172 0.803058435633711 0.6927368669812094 0.6693004463716118 0.7310826537002961 0.8484738697478039 0.7926422186805897 0.8525654612889942 0.7987127707556271 1.0 10.866057838634957 -8.965212897729717 0.39459448427017335 1.0220015908305922 0.7330657912051737 0.6824856752488573 0.050051941485601374 1.4297685507582434 0.4471448191763518 0.12476605211987249 0.04285958410259985 1.083395686857057e-09 8.965212897729717 -0.2889357996254185 DHAPSIPTS(ph)PFGDSLESSTELR ddPTM_A459_Selumetinib_30min_R2 2 DHAPSIPTSPFGDSLESSTELR 22 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 DHAPSIPT(0.021)S(0.979)PFGDSLESSTELR;DHAPSIPT(0.058)S(0.942)PFGDSLESSTELR 151.23 1.3061e-07 24654000.0 66458.0 54427.0 66694.0 65329.0 77306.0 62056.0 69387.0 78418.0 73695.0 71292.0 True False 62764.53041245276 58601.37588961172 62402.980650936675 56431.07750118913 67594.1291555913 70603.65071171933 72613.63298773214 78646.18339720118 88436.05921034334 69233.61472113889 0.9065615115613638 0.8464295288588932 0.9013393407564398 0.8150820627881965 0.9763195151350806 1.0197885954113288 1.0488204794767308 1.1359537374146143 1.277357242815482 1.0 16.079185053489454 -6.96990923140141 1.144699681272386 1.1471838175005207 0.8674670415586626 0.7026805929154061 0.07202231538144029 0.2516500169392043 0.6808433528932465 0.040957174326297495 0.030271060951432168 1.0717432787723373e-07 6.96990923140141 -0.27971677594185806 DHAPSIPTS(ph)PFGDSLESSTELRR ddPTM_A459_Selumetinib_30min_R1 2 DHAPSIPTSPFGDSLESSTELRR 23 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 DHAPSIPT(0.216)S(0.784)PFGDSLESSTELRR;DHAPSIPT(0.011)S(0.989)PFGDSLESSTELRR 155.31 1.1578e-09 94073000.0 3461.5 4052.8 4876.4 5025.6 4650.1 3889.8999999999996 4559.8 4147.9 2289.0 2640.7 True False 3542.146215093489 3578.296291904398 4214.211664147848 4147.9733021957645 4229.499276041837 3850.7711377466103 4215.850614883957 4037.8842177219476 3884.265818054613 2979.659567596224 1.1887754740891554 1.2009077583286172 1.4143265593081065 1.3920963815145004 1.4194572165349395 1.2923527169424716 1.4148766056133733 1.3551495149425488 1.3035938267230176 1.0 11.540931793807069 -8.764348177888005 3.863269277233087 1.0000033413620546 1.3386189714256473 0.6056535108723448 0.08048997434057094 2.394334349588886 37.756107462398916 0.08358551394247916 0.021916043389720308 1.7204886902901056e-09 8.764348177888005 0.33861563006359274 DHAPSIPTS(ph)PFGDSLESSTELRR ddPTM_A459_Selumetinib_30min_R2 1 DHAPSIPTSPFGDSLESSTELRR 23 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 DHAPSIPT(0.425)S(0.575)PFGDSLESSTELRR 104.16 1.691e-05 10019000.0 18219.0 16959.0 23512.0 21612.0 19935.0 14156.0 15295.0 16161.0 17207.0 23528.0 True False 17206.460916435593 18259.70076822027 21999.263517930012 18668.40831722052 17430.587078838824 16105.860504626462 16006.24780646753 16208.025834402426 20648.880803750275 22848.685506914568 0.7530613046089019 0.7991576041735285 0.9628240325366858 0.8170451780068927 0.762870453688196 0.7048922135915625 0.7005325449301515 0.7093636012232513 0.9037229208438018 1.0 14.479823548456197 -1.526329856429136 24.988515078141834 0.7999205384495884 0.0010284586135818063 0.0 0.10407474261193188 0.0 0.0 0.024113726825052296 0.0 0.02976255038092182 1.526329856429136 -0.7988920798360066 DHFEEAMR ddPTM_A459_Selumetinib_30min_R1 3 DHFEEAMR 8 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ;; 214.64 0.00038538 97558000.0 20889.899999999998 23776.3 24883.1 25582.4 24269.1 20100.1 20945.5 20075.300000000003 12351.9 18974.3 False True 21376.594025330476 20992.559742698002 21504.11169308449 21114.914081123236 22073.964190057613 19897.911243430597 19365.564071681212 19542.837830235407 20960.272152917776 21409.83623033326 0.9984473395945137 0.9805100570062247 1.004403371503499 0.9862249226926741 1.0310197589827157 0.9293817584293063 0.9045171510580851 0.9127971657507259 0.9790019842945576 1.0 14.385986139747898 -6.776303544514269 24.999805074852837 0.9371505166228843 0.9984974844343938 0.4456682736396428 0.029977869691857683 198.8953251253061 334517.00698043837 0.01033652530605897 0.009153334578300731 1.673772605374608e-07 6.776303544514269 0.0613469678115095 DHFEEAMR ddPTM_A459_Selumetinib_30min_R2 4 DHFEEAMR 8 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ;;; 184.38 0.00022430000000000006 95737600.0 867870.0 846020.0 911141.0 911737.0 900760.0 733079.0 742947.0 752568.0 623123.0 805567.0 False True 819637.2597588758 910907.01361694 852519.1800353113 787556.8477659494 787598.4759034296 834053.9780214082 777495.5076215521 754757.8482856606 747765.0115113207 782308.1875955748 1.047716581208273 1.1643838426600313 1.089748507753102 1.0067091975433702 1.0067624094848278 1.0661450196307853 0.9938481022564593 0.9647832660494196 0.9558445423018995 1.0 19.57737753865218 -6.067943647239267 0.640064721876926 0.976757388926641 1.1232801640667018 0.5568418106310806 0.04010221997598367 0.7610560652831884 0.6125597395007851 0.02669866573844868 0.06596839315184345 8.551776709977153e-07 6.067943647239267 0.14652277514006085 DHFGLEGDEESTMLEDS(ph)VSPK ddPTM_A459_Selumetinib_30min_R1 1 DHFGLEGDEESTMLEDSVSPK 21 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 DHFGLEGDEESTMLEDS(0.877)VS(0.123)PK 130.98 3.3818e-05 13203000.0 2988.2 3146.8 3569.3 3378.3 2624.8 2701.5 3318.8 3185.4 2288.3 3503.6 True False 3057.8192459749707 2778.37119309237 3084.6086647614848 2788.343323545042 2387.387303446078 2674.3253627657464 3068.460244018792 3100.912844362565 3883.0779691805883 3953.3211879539977 0.7734811062891439 0.7027941978400922 0.7802575399541198 0.7053166669182581 0.6038940905486222 0.6764756101564865 0.7761727666774384 0.7843817127258036 0.9822318462290783 1.0 11.94884945647643 -8.15329623309783 1.7720534316514809 1.0109360649877879 0.7095202602848896 0.8217198665002278 0.05042461165897097 0.15121625388555318 0.8502831079169144 0.049687068240829926 0.015289188282980237 7.025929164275716e-09 8.15329623309783 -0.3014158047028983 DHFGLEGDEESTMLEDS(ph)VSPKK ddPTM_A459_Selumetinib_30min_R1 1 DHFGLEGDEESTMLEDSVSPKK 22 1 Q9Y490 Q9Y490 TLN1 Talin-1 1 DHFGLEGDEES(0.005)T(0.003)MLEDS(0.575)VS(0.417)PKK 72.399 0.0020455 22000000.0 3825.4 4187.8 4302.6 4549.5 3405.2 3681.1 3653.8 3469.7 2194.3 3775.3 True False 3914.5243770673487 3697.490429144598 3718.33055249006 3755.0152296919055 3097.2002612368888 3644.0714761713784 3378.190924308742 3377.6722848260174 3723.5668346689554 4259.896529536116 0.9189247555488451 0.8679765819446413 0.872868748503375 0.8814803842432319 0.727059974288662 0.8554366170410721 0.793021825972992 0.7929000766583951 0.8740979525797157 1.0 12.056602673296762 -6.057685261725399 24.99997740989757 0.8262476371799248 0.8834704840546921 0.07156243826298048 0.06855304719852309 522.4637769573907 226427.1968065785 0.01893169234352633 0.024440778582728657 8.756181160003477e-07 6.057685261725399 0.05722284687476731 DHFGLEGDEESTMLEDSVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 DHFGLEGDEESTMLEDSVSPK 21 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 DHFGLEGDEESTMLEDS(0.248)VS(0.752)PK;DHFGLEGDEESTMLEDS(0.114)VS(0.886)PK;DHFGLEGDEESTMLEDS(0.017)VS(0.983)PK 163.61 2.3017e-08 64953000.0 8619.1 10962.6 10577.0 10244.2 8344.9 9252.9 9383.2 10006.699999999999 6074.2 10825.300000000001 True False 8819.90826015088 9679.093695625528 9140.701495302228 8455.242777450227 7590.105268411758 9159.824226961007 8675.417669542343 9741.289809657465 10307.473757984859 12214.83270235142 0.7220654162912113 0.7924049335331668 0.7483280138206555 0.692211099692143 0.6213843000036032 0.7498935474734495 0.710236307032865 0.7974967850179573 0.8438489506287398 1.0 13.576346483748903 -8.517121732702215 1.1646596704502463 0.9979723525011697 0.7185134404978638 0.7994181413799039 0.04352438779936073 0.23667706224877144 0.7042289826339002 0.045052621719345896 0.0142341326214379 3.0400327853381214e-09 8.517121732702215 -0.27945891200330586 DHFGLEGDEESTMLEDSVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 DHFGLEGDEESTMLEDSVSPK 21 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 DHFGLEGDEES(0.001)T(0.012)MLEDS(0.262)VS(0.725)PK;DHFGLEGDEESTMLEDS(0.058)VS(0.942)PK;DHFGLEGDEESTMLEDS(0.172)VS(0.828)PK 149.62 3.8847e-06 35282700.0 161044.0 135005.0 151083.0 122720.0 138153.0 113940.0 145979.0 134836.0 92264.0 138809.0 True False 152093.8191902109 145359.4493905055 141362.48426673276 106005.32429619206 120796.98503650965 129634.2007556612 152767.31275190107 135228.35043669867 110719.37807155306 134801.22350090544 1.1282821864683543 1.078324406970454 1.0486735995076726 0.7863825085792343 0.8961119335515398 0.9616693186378272 1.1332783841600291 1.003168568687289 0.8213529165097627 1.0 17.040474065397817 -5.537076888970505 24.998532154906815 0.9475067251097716 1.0933522743754245 0.3369685881251524 0.09302076640991844 283.9715357057547 499984.1006751177 0.027368481092456674 0.04742954202712707 2.9035085619375527e-06 5.537076888970505 0.14584554926565285 DHFLGPQESFPEENAS(ph)SPFTQAR ddPTM_A459_Selumetinib_30min_R2 1 DHFLGPQESFPEENASSPFTQAR 23 0 A0A0U1RRL2;B1AM27;O14795;O14795-2;A0A1B0GUS7 A0A0U1RRL2 UNC13B Protein unc-13 homolog B 1 DHFLGPQESFPEENAS(0.376)S(0.312)PFT(0.312)QAR 90.974 0.00010402 2645000.0 11186.0 11208.0 11165.0 13561.0 14470.0 10475.0 9459.9 10140.0 8142.9 10158.0 True False 10564.326901105902 12067.617560599843 10446.656055532865 11713.968405970174 12652.149236558698 11917.836167417505 9899.804094436236 10169.505721232636 9771.707531635848 9864.712146346401 1.0709209497834782 1.223311677175429 1.058992487621851 1.1874617558210945 1.2825664904215863 1.2081281228090899 1.0035573210418343 1.0308973612574313 0.9905719889915896 1.0 13.26806123818593 -7.2674498074810945 24.62235051169216 1.0088314339053615 1.1748398588737723 0.6196643344327473 0.06353569464996296 284.50354862103364 1165491.5445972797 0.027163275199619252 0.01885919176557296 5.401945428156277e-08 7.2674498074810945 0.16600842496841084 DHFLGPQESFPEENASS(ph)PFTQAR ddPTM_A459_Selumetinib_30min_R2 1 DHFLGPQESFPEENASSPFTQAR 23 0 A0A0U1RRL2;B1AM27;O14795;O14795-2;A0A1B0GUS7 A0A0U1RRL2 UNC13B Protein unc-13 homolog B 1 DHFLGPQESFPEENAS(0.215)S(0.65)PFT(0.135)QAR 122.65 6.9387e-06 2226400.0 22221.0 20472.0 24779.0 25232.0 27781.0 17416.0 18590.0 20790.0 18688.0 19870.0 True False 20986.045777710915 22042.136572144915 23184.74611733531 21795.358072372204 24290.90241470887 19814.895913292905 19454.47183538616 20850.495458030215 22426.12218634771 19296.301471539977 1.087568299482838 1.1422985179131222 1.2015124323969744 1.1295096163644662 1.2588372155428547 1.0268753285450998 1.008196926446214 1.0805436206924166 1.1621979589935352 1.0 14.236036731706166 -6.786566766975258 24.99986723444141 1.0576363564259887 1.1629166536957547 0.44849235587628256 0.06006600924774102 228.41668159894522 227255.8225846614 0.0214936780386049 0.018963347593533856 1.634681821317184e-07 6.786566766975258 0.10528029726976595 DHGFEVAST(ph)SPEDESPGSNPEPDATPFQEGLR ddPTM_A459_Selumetinib_30min_R1 1 DHGFEVASTSPEDESPGSNPEPDATPFQEGLR 32 0 Q5JRU2;F8VVS7;P55211-2;P55211-4;P55211 Q5JRU2 CASP9 Caspase;Caspase-9;Caspase-9 subunit p35;Caspase-9 subunit p10 1 DHGFEVAS(0.122)T(0.448)S(0.242)PEDES(0.172)PGS(0.016)NPEPDATPFQEGLR 98.355 1.1100000000000002e-08 6567100.0 240.73 247.05 325.14 372.28 375.14 170.85 356.52 371.9 149.45 389.4 True False 246.33854062096063 218.1252711495709 280.98777386617803 307.2682865610953 341.20865323634627 169.1314041193883 329.62740936410125 362.036003898549 253.60573460387158 439.38328307720246 0.5606461376858467 0.4964350705878924 0.6395049258549208 0.69931719843585 0.7765626649396075 0.38492908272450327 0.7502047120581591 0.8239639919002948 0.577185669941183 1.0 8.7793361713238 -14.522878729395238 0.13834513745930976 2.241836648658185 0.5057211176521499 0.46009576428386145 0.123857722005272 129.97811165296423 1.1031929872798296 44.479122862476686 0.7995165991595957 3.000000109730383e-15 14.522878729395238 -1.7361155310060352 DHGFEVAST(ph)SPEDESPGSNPEPDATPFQEGLR ddPTM_A459_Selumetinib_30min_R2 1 DHGFEVASTSPEDESPGSNPEPDATPFQEGLR 32 0 Q5JRU2;F8VVS7;P55211-2;P55211-4;P55211 Q5JRU2 CASP9 Caspase;Caspase-9;Caspase-9 subunit p35;Caspase-9 subunit p10 1 DHGFEVAS(0.054)T(0.347)S(0.347)PEDES(0.162)PGS(0.09)NPEPDAT(0.001)PFQEGLR 46.668 0.02575 3539600.0 2942.3 1210.3 1333.1 2401.6 2599.0 1142.8 1185.9 1007.7 1251.4 1319.9 True False 2778.7787449601196 1303.1261182721269 1247.329797369534 2074.4979370089195 2272.4903846452003 1300.2103266944835 1241.0466998162694 1010.6322401662843 1501.7149670374313 1281.7910574879513 2.167887448369283 1.016644725877545 0.9731147600717746 1.6184368933533613 1.772902355161392 1.0143699467233218 0.9682129490343516 0.7884531837403493 1.171575475007983 1.0 10.323945394595919 -6.871043367362703 8.167197067065956 0.9688942968190447 1.457817047672509 0.36983147658605486 0.33673847429840925 0.3057284609970577 20.99514120872828 0.12226670446163565 0.10788117952032333 1.3457259671307113e-07 6.871043367362703 0.48892275085346426 DHGFEVASTSPEDESPGS(ph)NPEPDATPFQEGLR ddPTM_A459_Selumetinib_30min_R1 1 DHGFEVASTSPEDESPGSNPEPDATPFQEGLR 32 0 Q5JRU2;F8VVS7;P55211-2;P55211-4;P55211 Q5JRU2 CASP9 Caspase;Caspase-9;Caspase-9 subunit p35;Caspase-9 subunit p10 1 DHGFEVAS(0.108)T(0.193)S(0.193)PEDES(0.171)PGS(0.334)NPEPDAT(0.001)PFQEGLR 54.517 0.0013343 5186500.0 386.42 527.91 508.86 406.03 397.02 505.61 625.52 401.79 153.76 433.72 True False 395.42283415756907 466.1020517812995 439.7596069679008 335.1244826270587 361.10961109957407 500.52402245714916 578.336522790959 391.1332240021458 260.9194898139264 489.3921867905606 0.807987632068171 0.9524100800178319 0.8985832198340746 0.6847769369282514 0.7378736744199677 1.0227462472165552 1.1817444953171328 0.7992224529925618 0.5331500928223627 1.0 8.934847258563316 -10.845447754598698 4.869359099865876 1.0000719681417531 0.8568482823992903 0.0635654691470583 0.17268632506458492 0.0001437509085007083 1.9998578745752593e-05 0.1781479577527561 0.04318554340005985 1.4274215379084232e-11 10.845447754598698 -0.1432236857424628 DHGGALGPEEFK ddPTM_A459_Selumetinib_30min_R2 1 DHGGALGPEEFK 12 0 O43707;O43707-2;F5GXS2;O43707-3 O43707 ACTN4 Alpha-actinin-4 0 127.52 0.0036269 5344000.0 55079.0 37010.0 41220.0 46192.0 49117.0 38210.0 62940.0 60946.0 47991.0 40290.0 False True 52017.929678706634 39848.54799409356 38567.95007694265 39900.56991435546 42946.48334844877 43473.08066415492 65866.83471324395 61123.34276984654 57590.540980576494 39126.72301400831 1.3294732007094732 1.018448388325974 0.9857188925107373 1.0197779635179285 1.0976253578167763 1.1110841214223461 1.6834232370971123 1.5621891653937618 1.4718978883040548 1.0 15.255866664605094 -7.1714675286580025 7.349596322359445 1.4753959054694674 1.0801526942299744 0.42316136053318665 0.18873128399532235 0.22175189039289592 15.848425324452199 0.06951129855803626 0.053752342623187725 6.73802272454461e-08 7.1714675286580025 -0.395243211239493 DHHTADLCR ddPTM_A459_Selumetinib_30min_R1 2 DHHTADLCR 9 0 P21980-2;P21980;A2A299;P21980-3;A2A2A0 P21980-2 TGM2 Protein-glutamine gamma-glutamyltransferase 2 0 ; 105.1 0.019588 5243900.0 2510.1 3369.0 2899.2 3194.9 4624.0 3333.4 2848.8999999999996 2609.6 1150.97 2130.1 False True 2568.5804461956277 2974.555913794392 2505.5045641656625 2636.970690700663 4205.7600164335045 3299.86902248504 2634.00517933745 2540.3849308245594 1953.1120264772023 2403.5190839310467 1.0686748706794609 1.237583647111881 1.0424317330852289 1.0971290839046708 1.749834251182572 1.372932316013892 1.095895263302605 1.056943940161966 0.8126051669549523 1.0 11.230932543175706 -7.714327243030206 2.32845798635638 0.9248751058160161 1.2615888114198737 0.32383330409103517 0.19904890835322556 0.39403297066432336 4.266264155286047 0.13940255605322996 0.06262531122515921 1.9305131176974827e-08 7.714327243030206 0.3367137056038576 DHHTADLCR ddPTM_A459_Selumetinib_30min_R2 1 DHHTADLCR 9 0 P21980-2;P21980;A2A299;P21980-3;A2A2A0 P21980-2 TGM2 Protein-glutamine gamma-glutamyltransferase 2 0 94.309 0.032895 2991900.0 9826.2 4749.8 11977.0 6746.7 12609.0 4231.6 4880.0 9703.2 5567.6 8106.9 False True 9280.099141395212 5114.094386985831 11206.412859571612 5827.787821293336 11024.944694109796 4814.4644893598 5106.929669536551 9731.434705548765 6681.27557174173 7872.8327327442075 1.1787496897778595 0.6495875830964375 1.4234282932193618 0.7402402691797013 1.4003783731179142 0.611528868044633 0.6486775272509118 1.2360779195872373 0.8486495012085516 1.0 12.942667111520832 -6.779144887438422 24.999477802117447 0.8699724627774874 1.0550228873338081 0.11781161694292985 0.28300654971757966 626.869750398858 885109.4032883849 0.09650381745313114 0.08528428686306895 1.6628578024259564e-07 6.779144887438422 0.1850504245563207 DHLPPPS(ph)SASPSR ddPTM_A459_Selumetinib_30min_R1 1 DHLPPPSSASPSR 13 0 Q2YD98;Q2YD98-2 Q2YD98 UVSSA UV-stimulated scaffold protein A 1 DHLPPPS(0.332)S(0.332)AS(0.332)PS(0.004)R 89.74700000000001 0.022048 3989400.0 3040.6 3809.0 3934.4 3931.2 3642.3 3478.9 3498.2 3288.4 1840.3 2913.0 True False 3111.4400640223207 3363.0405092439396 3400.1300901122313 3244.6897177634514 3312.8546081002924 3443.90542458847 3234.327957583022 3201.1809497714153 3122.854689805988 3286.9119250228323 0.9466149793474333 1.0231611269050291 1.0344451471995595 0.9871544451988662 1.0078927223087306 1.0477632206602394 0.9840020150708951 0.9739174711075286 0.9500877300763985 1.0 11.682517083631216 -7.507575241638644 23.719946381297888 0.9729934922701545 1.0093964022391861 0.22553442173942173 0.028252914769926755 491.14185472002816 761260.5698741043 0.01208259889750283 0.007832593837900298 3.1075974639816665e-08 7.507575241638644 0.036402909969031616 DHLPPPSSAS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 DHLPPPSSASPSR 13 0 Q2YD98;Q2YD98-2 Q2YD98 UVSSA UV-stimulated scaffold protein A 1 DHLPPPS(0.062)S(0.062)AS(0.846)PS(0.029)R 86.772 0.023755 0.0 23579.0 24500.0 29291.0 30002.0 32722.0 25184.0 20272.0 21099.0 22955.0 25173.0 True False 22268.573574215636 26379.071220083526 27406.44894962946 25915.675843663237 28611.16982160843 28652.867402409775 21214.68816820594 21160.394596872506 27546.64141628915 24446.19008269127 0.9109220495664286 1.0790667638128528 1.1210928515619352 1.0601110339075868 1.1703733679902173 1.1720790563064865 0.8678116343056113 0.8655906922631179 1.1268275883935428 1.0 14.577322019487637 -7.260522098666105 24.998822495328355 0.9538567046721711 1.0896172438136933 0.2662503628976912 0.09719511521887522 109.09939920796816 2973364.1101978663 0.03945298814740372 0.028718098829927475 5.4888062562223513e-08 7.260522098666105 0.1357605391415222 DHNS(ph)EDEDEDKYADDIDMPGQNFDSK ddPTM_A459_Selumetinib_30min_R2 2 DHNSEDEDEDKYADDIDMPGQNFDSK 26 1 O95391 O95391 SLU7 Pre-mRNA-splicing factor SLU7 1 DHNS(0.961)EDEDEDKY(0.039)ADDIDMPGQNFDSK;DHNS(0.593)EDEDEDKY(0.407)ADDIDMPGQNFDSK 73.153 0.00015775 18905900.0 73967.0 47414.0 52663.0 50045.0 48514.0 44970.0 69837.0 69820.0 48512.0 48398.0 True False 69856.21025336142 51050.50133996087 49274.719915139 43228.784667559696 42419.23759933718 51164.20930298469 73084.55887939029 70023.16464067672 58215.75553853277 47000.62398689439 1.4862826134572185 1.0861664592835139 1.0483843773835582 0.9197491650241404 0.9025249879909111 1.088585745526512 1.5549699701810153 1.4898347873041413 1.2386166522973312 1.0 15.520392289889136 -7.1583398337487285 8.31252136760956 1.3611765649659535 1.0692588844484132 0.2217087705070352 0.20603461618072288 0.39288013954320833 28.573394884005957 0.08003963224251903 0.061966076502283626 6.944806764805237e-08 7.1583398337487285 -0.2919176805175403 DHQYQFLEDAVR ddPTM_A459_Selumetinib_30min_R1 2 DHQYQFLEDAVR 12 0 Q13263-2;Q13263;M0R3C0;M0R2I3 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 0 ; 144.28 0.0010616 23199000.0 8990.9 11461.9 7408.700000000001 6470.5 8585.2 7398.3 9280.4 9670.0 5186.0 8606.8 False True 9200.370476754017 10119.935419507256 6402.639233076072 5340.548641327945 7808.670175840165 7323.879819118937 8580.371956307097 9413.5201874132 8800.263229546183 9711.566617331458 0.9473621341725493 1.0420497349466784 0.6592797522131797 0.5499162855761185 0.804058756277762 0.7541398939743247 0.8835208874533581 0.9693101595589779 0.9061630915285135 1.0 13.24548832683051 -7.485711644230481 3.5754848197820084 0.9518947917202794 0.7879349785054479 0.24647415145870366 0.13023037897868486 0.3968850656759701 10.516747868769682 0.07014216729066304 0.04216996198384333 3.268047466402728e-08 7.485711644230481 -0.16395981321483144 DHQYQFLEDAVR ddPTM_A459_Selumetinib_30min_R2 2 DHQYQFLEDAVR 12 0 Q13263-2;Q13263;M0R3C0;M0R2I3 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 0 ; 112.02 0.0092053 5663600.0 43175.0 34264.0 39705.0 36617.0 45555.0 40682.0 43008.0 49963.0 38729.0 39235.0 False True 40775.50634321899 36891.9386238752 37150.42352753536 31629.701432151727 39831.97363313282 46285.576225573124 45007.95721873524 50108.38405818006 46475.88217867404 38102.1836052275 1.0701619299746568 0.9682368602836121 0.9750208521497553 0.8301283139009448 1.0453987111559662 1.214774898602475 1.1812435131030203 1.3151053120038334 1.2197695192539486 1.0 15.217586059319526 -6.633561660220297 3.9528070249206104 1.2055313429448287 0.9597904295555358 0.566911064202898 0.09232738894446256 0.15083957973808773 4.3786034352808345 0.03100274070862876 0.030891031437461778 2.3250823521189e-07 6.633561660220297 -0.24574091338929283 DHRPPCAQEAPR ddPTM_A459_Selumetinib_30min_R1 1 DHRPPCAQEAPR 12 1 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 0 100.09 0.010968 4321700.0 1050.3 912.3 1229.2 1281.5 913.48 979.71 973.6 1229.1 600.74 916.5 False True 1074.7699464719597 805.487491883236 1062.2813915122904 1057.7100817342957 830.8558952879926 969.8550069055077 900.1605681501428 1196.500275320534 1019.4119036863823 1034.14170246599 1.0392869216173068 0.7788947007576326 1.0272106704324941 1.0227902802992135 0.8034255782420854 0.9378356994914858 0.8704421898891043 1.1569983808479898 0.9857564986070252 1.0 10.014218168030755 -7.747219268139722 24.99941669243312 1.053533116729443 0.9234544233637488 0.25541758087037847 0.09515054718991829 287.30889025322733 505100.1839030024 0.04352234957017191 0.024979157139466707 1.7897020347761868e-08 7.747219268139722 -0.13007869336569422 DHS(ph)PTPSVFNR ddPTM_A459_Selumetinib_30min_R2 1 DHSPTPSVFNR 11 0 H0Y8P7 H0Y8P7 FIP1L1 1 DHS(0.995)PT(0.005)PSVFNR 76.24 0.034234 5192200.0 25024.0 19621.0 28388.0 27298.0 39998.0 23035.0 20488.0 22511.0 19510.0 29337.0 True False 23633.266259008968 21125.867608541193 26561.546986517405 23579.96530832342 34973.09365334313 26207.862159089458 21440.732596201815 22576.503283103335 23412.54515494669 28489.96458331998 0.8295295064299777 0.7415196163813329 0.9323123905204289 0.8276586388643242 1.2275583407997224 0.919898025230729 0.7525714022387631 0.79243704277264 0.8217821782991627 1.0 14.798166207757356 -5.266427084672692 24.616467177586323 0.9050991985637378 0.7855245591452744 0.12750722458692 0.12911806853084096 714.7902220590674 3527820.600394262 0.036270504799604926 0.07953937286146194 5.414681493673577e-06 5.266427084672692 -0.11957463941846336 DHS(ph)PTPSVFNS(ph)DEER ddPTM_A459_Selumetinib_30min_R2 2 DHSPTPSVFNSDEER 15 0 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 2 DHS(0.999)PT(0.002)PSVFNS(0.999)DEER;DHS(1)PT(0.001)PSVFNS(0.999)DEER 177.07 4.0265e-05 4788300.0 41027.0 30289.0 41173.0 39290.0 52063.0 33117.0 37113.0 43507.0 31775.0 35412.0 True False 38746.88358409369 32612.068905514698 38523.9740057729 33938.63422096953 45522.38049087463 37678.56614380575 38838.828038014355 43633.598167028445 38130.88786767972 34389.563548574384 1.126704720441267 0.948312963014229 1.1202228243274668 0.9868876112089084 1.3237266133539447 1.0956395561864498 1.129378335469582 1.2688034875870726 1.1087924338970108 1.0 15.069683185722296 -6.216410761936935 24.99994237234344 1.1636424248872927 1.0439228670908411 0.22287159331190165 0.09866125178522445 599.1268675574709 332635.7237836519 0.02728051459501348 0.03521885310911228 6.075600904127419e-07 6.216410761936935 -0.1197195577964516 DHS(ph)PTPSVFNS(ph)DEERYR ddPTM_A459_Selumetinib_30min_R1 1 DHSPTPSVFNSDEERYR 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 2 DHS(0.921)PT(0.079)PS(0.004)VFNS(0.996)DEERYR 76.533 0.015977 3724200.0 996.93 1066.4 1032.2 1061.7 1138.3 1037.3 901.22 932.27 587.11 831.87 True False 1020.1565293119021 941.5453922440902 892.0329094687492 876.294025577293 1035.340965983187 1026.865703793043 833.240249823615 907.5431711602596 996.2827891821952 938.6486175999814 1.0868353824675385 1.003086111873808 0.9503374241892313 0.9335698249019723 1.1030122950912526 1.0939830779473394 0.8877019943353417 0.9668614582107893 1.0614012213959019 1.0 9.874441376918965 -12.159045750894942 0.003100511458642556 5.993272324878075e-05 1.9731848920510167 0.005835888848574 0.07092544807619393 788456.2043043722 287.9194632493313 94406.39122513022 88890.66911174891 6.933527606946757e-13 12.159045750894942 1.9731249593277678 DHS(ph)PTPSVFNS(ph)DEERYR ddPTM_A459_Selumetinib_30min_R2 1 DHSPTPSVFNSDEERYR 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 2 DHS(0.981)PT(0.019)PSVFNS(0.994)DEERY(0.006)R 84.37100000000002 0.024289 11020000.0 34537.0 46691.0 56891.0 46834.0 47426.0 28915.0 29089.0 29828.0 18686.0 46859.0 True False 32617.571802565217 50272.049564772264 53230.69499823733 40455.12840684368 41467.92188618058 32897.77878576391 30441.696138759995 29914.79454170876 22423.722130463026 45506.058915696594 0.7167742621480742 1.1047331006603984 1.1697496172290203 0.8890053186497617 0.911261552291378 0.7229318374221229 0.6689591861856359 0.6573804731613471 0.4927634399631192 1.0 15.473771025644966 -6.657142899791528 1.7889252065783932 0.673703253268287 0.9970027271080061 0.363031673354954 0.1642472474238534 0.3352504595058115 2.2075569273951356 0.06464106972223918 0.06381864110204126 2.2022017337263241e-07 6.657142899791528 0.32329947383971913 DHS(ph)PTPSVFNSDEER ddPTM_A459_Selumetinib_30min_R1 3 DHSPTPSVFNSDEER 15 0 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DHS(1)PTPSVFNSDEER;DHS(1)PTPSVFNSDEER;DHS(0.998)PT(0.002)PSVFNSDEER 279.19 4.1405e-55 150788000.0 3753.69 4554.6 4238.29 3904.37 3825.7 3321.18 3991.33 3911.08 1909.78 3662.63 True False 3841.143673590718 4021.3453146239067 3662.7534972605154 3222.5450736019734 3479.666110482192 3287.7719445901675 3690.260764661784 3807.3454534217185 3240.7571751875657 4132.764237537377 0.9294369223151163 0.9730400970126807 0.8862720655565557 0.7797553618791032 0.8419706304261982 0.7955382295287374 0.8929279660193558 0.9212588075651834 0.7841621222309699 1.0 12.012891349067187 -5.443997450369042 5.169041549221643 0.8526496481529784 0.9489569477900649 0.23095185090725923 0.06516731506626645 0.2798037576423925 13.035682393814245 0.016653099845182616 0.035232899135532084 3.5975144715755825e-06 5.443997450369042 0.09630729963708651 DHS(ph)PTPSVFNSDEER ddPTM_A459_Selumetinib_30min_R2 2 DHSPTPSVFNSDEER 15 0 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DHS(0.999)PTPSVFNSDEER;DHS(0.993)PT(0.006)PSVFNSDEER 268.18 8.383600000000001e-45 105819000.0 236404.0 212687.0 271963.0 265339.0 285631.0 196371.0 190296.0 222625.0 139345.0 247174.0 True False 223265.6120801929 228999.40900350682 254465.19667092603 229199.37046469396 249747.48020646142 223419.32277154562 199145.14106437025 223272.8018924471 167217.8936246053 240037.4443848219 0.9301282666643425 0.9540153603551154 1.0601062568512183 0.9548484031401675 1.040452171312375 0.930768627970249 0.829641981794748 0.9301582195422056 0.6966325360326943 1.0 17.872899949498155 -7.030635177956523 4.7832053452034735 0.8597042332574473 0.9884192465237145 0.33992620410071794 0.0811159169341321 0.21689618086803236 12.383241214124977 0.02931506353767381 0.023493868355238968 9.318903661669547e-08 7.030635177956523 0.12871501326626722 DHS(ph)PTPSVFNSDEERYR ddPTM_A459_Selumetinib_30min_R1 2 DHSPTPSVFNSDEERYR 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DHS(0.492)PT(0.492)PS(0.015)VFNSDEERYR;DHS(0.498)PT(0.498)PS(0.003)VFNSDEERYR 75.358 0.012201 22673800.0 1826.22 1465.28 3255.5 3070.5 2983.2 1973.44 1800.88 1761.41 1137.0900000000001 1436.41 True False 1868.7673727944625 1293.7243364098092 2813.4209811814676 2534.2948154234523 2713.3700867267376 1953.588985340156 1665.0381717031933 1714.69168493397 1929.558680232293 1620.7872153182464 1.152999823254112 0.7982073921750318 1.735836113828825 1.563619697559026 1.6741062991380762 1.2053334126013346 1.0273021381009957 1.0579375680707632 1.190507095561843 1.0 10.662478984058328 -6.993500352584268 24.92694640056038 1.079843789923677 1.3875705686275033 0.25277160204616433 0.256635773951272 258.3724718906259 990883.6543496978 0.09976994984468407 0.0877720514603787 1.0150785424754838e-07 6.993500352584268 0.30772677870382625 DHSPT(ph)PSVFNS(ph)DEERYR ddPTM_A459_Selumetinib_30min_R2 1 DHSPTPSVFNSDEERYR 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 2 DHS(0.432)PT(0.568)PSVFNS(1)DEERYR 98.76 0.016842 0.0 25254.0 27418.0 27887.0 20560.0 25077.0 15745.0 14283.0 13689.0 11716.0 24474.0 True False 23850.483779771897 29520.872437234717 26092.780781069843 17759.692532021738 21926.603068775577 17913.73083112061 14947.187801227577 13728.83272366406 14059.527372391356 23767.372028911384 1.0034968843319916 1.242075581655582 1.0978403817355051 0.7472299634313077 0.9225505891902295 0.7537110459385152 0.6288952679768443 0.5776336023588924 0.5915474102601206 1.0 14.536694772082813 -5.994981048817103 1.0184593248361284 0.6801094946422092 1.157847386448933 0.551964440302956 0.14599795650051753 0.3900239338714702 0.8209730378100399 0.06023771065491597 0.12864734786489876 1.0116235972235527e-06 5.994981048817103 0.47773789180672377 DHSPT(ph)PSVFNSDEER ddPTM_A459_Selumetinib_30min_R1 1 DHSPTPSVFNSDEER 15 0 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DHS(0.499)PT(0.499)PS(0.003)VFNSDEER 98.676 0.011832 98457000.0 1818.0 2384.6 1830.4 1804.7 2088.0 1684.0 1940.2 1918.5 978.31 1876.5 True False 1860.355862787798 2105.409923429536 1581.8417336675043 1489.5430234146568 1899.1407686663415 1667.060488949662 1793.8491519360186 1867.6151478337365 1660.1206170646608 2117.367053657862 0.8786175545585903 0.9943528306971294 0.7470796010237291 0.703488335119503 0.8969350710286518 0.7873271127316958 0.8472074545776325 0.8820460036002421 0.7840495176293198 1.0 11.048055672377846 -10.198380731542404 6.850335033098609 1.0000000000003273 0.8359337310034968 0.2771373347117084 0.07961440585460289 2.335757108605485e-10 0.0 0.07992981193449956 0.019385826896570407 6.333142622494598e-11 10.198380731542404 -0.16406626899683052 DHSPT(ph)PSVFNSDEER ddPTM_A459_Selumetinib_30min_R2 1 DHSPTPSVFNSDEER 15 0 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DHS(0.27)PT(0.73)PSVFNSDEER 102.9 0.0081292 60825000.0 20538.0 25343.0 32052.0 32709.0 30713.0 20106.0 20441.0 28519.0 22436.0 18701.0 True False 19396.580180128123 27286.726609411307 29989.80921557899 28253.977773827777 26854.558362296288 22875.418995904165 21391.547003073076 28601.9855684254 26923.826914217534 18161.053538966728 1.0680316611869693 1.5024858855718006 1.651325411889362 1.5557455250712997 1.4786894551396261 1.2595865623556584 1.1778802896635339 1.574907838196523 1.482503581438666 1.0 14.148560276636175 -6.7457578835307475 24.673842832297222 1.3273389382522538 1.4710217471907152 0.10956436862083496 0.20556819351677058 523.4002302318742 823534.7204558541 0.06974652195683494 0.06950871984087066 1.795734458606264e-07 6.7457578835307475 0.14368280893846141 DHSPT(ph)PSVFNSDEERYR ddPTM_A459_Selumetinib_30min_R1 2 DHSPTPSVFNSDEERYR 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DHS(0.064)PT(0.926)PS(0.01)VFNSDEERYR;DHS(0.445)PT(0.539)PS(0.015)VFNSDEERYR 94.188 0.0095856 26173000.0 1795.93 1450.37 3659.2 3611.2 3090.7 2032.27 1810.74 1644.73 1365.17 1482.35 True False 1837.7716747285428 1280.560006141279 3162.300738546837 2980.5717106194998 2811.146730707405 2011.8272089535224 1674.1544239648624 1601.1064175640242 2316.5937819281853 1672.6240618117406 1.0987356434044833 0.7655994167357676 1.8906225318327174 1.7819734742970432 1.6806805515295815 1.2027970031558473 1.0009149468718417 0.9572422483446457 1.385005653582978 1.0 10.707897507022171 -6.963579444296784 8.762102034415047 1.0848781714417148 1.449333472307836 0.2133556232955921 0.32710297301949776 0.4865217774525884 107.43791174586102 0.12833678872060922 0.11277301119468673 1.0874781900365423e-07 6.963579444296784 0.3644553008661211 DHSPTPS(ph)VFNR ddPTM_A459_Selumetinib_30min_R1 1 DHSPTPSVFNR 11 0 H0Y8P7 H0Y8P7 FIP1L1 1 DHS(0.21)PT(0.098)PS(0.692)VFNR 89.35600000000002 0.031577999999999995 0.0 2096.6 2139.1 2510.6 2539.7 2252.7 2238.4 2332.6 2394.8 1623.5 2150.3 True False 2145.446700726564 1888.6531775593885 2169.674309738655 2096.189071073423 2048.9436827464883 2215.883728304587 2156.650104012967 2331.282124593293 2754.9609242514925 2426.311950695709 0.8842419047193782 0.7784049272880369 0.8942272691343474 0.863940463415008 0.8444683636656795 0.9132723958554525 0.8888593667416012 0.9608336322643228 1.1354520689153544 1.0 11.244549334209148 -7.9334908208717545 2.564275674756988 1.0671239675478792 0.863382465889725 0.743851950353871 0.046992032415108624 0.1348220812512717 1.7140051986087912 0.0335068505235064 0.012561680674112478 1.1654916840872772e-08 7.9334908208717545 -0.2037415016581542 DHT(ph)VSGDEDYCPR ddPTM_A459_Selumetinib_30min_R1 1 DHTVSGDEDYCPR 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 DHT(0.927)VS(0.073)GDEDYCPR 212.1 1.1618e-05 30606000.0 684.56 1115.6 1020.8 1328.8 832.19 846.85 787.18 590.76 384.72 609.55 True False 700.5089160781159 984.9850333716308 882.1809668530314 1096.7500246652603 756.9185614350779 838.3314578782795 727.8023788377461 575.0911257410779 652.8417411629407 687.7916800197972 1.0184899533212624 1.4320979185780196 1.2826281452367072 1.5945962368048587 1.1005055504790213 1.2188740896867918 1.058172699641841 0.8361414399844509 0.9491852840443628 1.0 9.425827853957577 -7.174560022264568 1.414828563728688 0.9185315139836042 1.3191381209425859 0.5120319484102754 0.15448489412679597 0.3236888482384896 1.2790395416666644 0.08715597506564025 0.05517077085959218 6.690213506426534e-08 7.174560022264568 0.40060660695898165 DHTVS(ph)GDEDYCPR ddPTM_A459_Selumetinib_30min_R1 1 DHTVSGDEDYCPR 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 DHT(0.138)VS(0.862)GDEDYCPR 184.96 0.00012472 28227000.0 1940.4 1899.3 2809.2 2733.7 2882.1 2463.1 2164.1 2463.4 1329.8 1813.0 True False 1985.6075446388577 1676.9290730393855 2427.7260698310492 2256.310612904442 2621.4145638760847 2438.3234503158656 2000.8601946730937 2398.0626297490876 2256.5734752507747 2045.7162101154825 0.9706173001028175 0.8197271277156871 1.1867364876059725 1.102944094468055 1.2814165283111794 1.1919167664894341 0.9780731974354074 1.1722362162900957 1.1030725885108907 1.0 10.998390307235027 -5.264866733093654 24.989676962292375 1.134849090448701 0.8951722072520629 0.5015750087742055 0.09219729114946236 208.0536443808247 1516982.8008769029 0.02378516137952823 0.052951948255799075 5.434170579949819e-06 5.264866733093654 -0.23967688319663805 DHTVS(ph)GDEDYCPR ddPTM_A459_Selumetinib_30min_R2 2 DHTVSGDEDYCPR 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 DHT(0.004)VS(0.996)GDEDYCPR;DHT(0.348)VS(0.652)GDEDYCPR 134.04 0.0012616 43783000.0 30444.0 29385.0 27694.0 22233.1 27697.0 27724.1 20717.1 25592.0 18047.300000000003 29702.0 True False 28752.044356988023 31638.735012332847 25912.198190947332 19204.913425763258 24217.455245678386 31542.84312067773 21680.486200154846 25666.468483016328 21657.264283693974 28844.426084936098 0.9967972415996059 1.0968751785585384 0.898343344209573 0.665810211276589 0.8395887362905746 1.093550727194079 0.7516352080056606 0.8898242040745804 0.7508301333478223 1.0 14.816004938054892 -5.386730944305572 5.2922732978386495 0.851294085009159 1.0444712673743255 0.28257998587285493 0.11931306998709243 0.2673441072651227 10.286140859904117 0.0315648161085612 0.06750613036362864 4.104583128583924e-06 5.386730944305572 0.19317718236516646 DHTVSGDEDYCPR ddPTM_A459_Selumetinib_30min_R2 1 DHTVSGDEDYCPR 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 86.803 0.036504 1993700.0 15087.0 9252.2 14548.0 13242.0 17998.0 11505.0 12237.0 10607.0 12912.0 10306.0 False True 14248.524938046196 9961.813989488035 13611.997518664768 11438.416756275865 15736.93033583853 13089.709318008423 12806.044747155493 10637.864613916625 15494.760791423467 10008.439001796223 1.4236510744072077 0.9953414301371253 1.360052003736228 1.1428772013520792 1.572366113538206 1.3078672224169225 1.2795246836052236 1.0628894887611782 1.5481695785569167 1.0 13.288929356722162 -10.790565386501749 4.047713655033583 0.9997177066184508 1.2882098391970127 0.1941200445494683 0.18164637782960213 124841983.64370213 192.16839590053777 364128.14386713837 0.04181307552341053 1.6197001167606606e-11 10.790565386501749 0.2884921325785619 DHVFEDSYR ddPTM_A459_Selumetinib_30min_R2 1 DHVFEDSYR 9 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 101.65 0.023657 3195600.0 20129.0 14436.0 21987.0 24114.0 23008.0 15793.0 14097.0 21126.0 16833.0 23766.0 False True 19010.31076277138 15543.194780943908 20572.38035763556 20829.631601029774 20117.529345870244 17968.342395420004 14752.538432675576 21187.47316240244 20200.07035331715 23079.813828516282 0.8236769544164683 0.6734540796745726 0.8913581587134528 0.9025043163603732 0.871650416911683 0.7785306471241638 0.6391965958775657 0.9180088418314813 0.87522674590897 1.0 14.494343966194908 -8.430067666019408 1.7203355598889865 0.9911059432949224 0.804988965945051 0.3091983150265982 0.08815908521873411 0.4501481353504771 2.852044185649305 0.08799327207103523 0.025501158509831926 3.714773459034946e-09 8.430067666019408 -0.18611697734987143 DHY(ph)DIRMLTFIMVAR ddPTM_A459_Selumetinib_30min_R1 1 DHYDIRMLTFIMVAR 15 1 C9JH00;O75155-2;O75155 C9JH00 CAND2 Cullin-associated NEDD8-dissociated protein 2 1 DHY(1)DIRMLTFIMVAR 72.321 0.02022 156250000.0 7238.6 10305.0 7807.8 8131.6 3704.9 9905.4 6088.6 3946.8 3045.9 3134.4 True False 7407.245296136272 9098.485809335476 6747.543645175449 6711.568709036749 3369.7924491532217 9805.76066938361 5629.3320000400145 3842.118042986806 5168.669836265854 3536.7307716414584 2.0943763533062034 2.5725695272848577 1.907847693491183 1.8976758883803284 0.9527986908625341 2.772549369041338 1.591676710361344 1.0863473334736227 1.461425867558187 1.0 11.788200684871093 -2.6928966939098236 0.11216668019316337 0.5509845511921407 5.143640248415822 0.3748036523154368 0.4765006421507109 87.50217871088114 0.8976327084486176 4.728428550078063 61.037049503395885 0.002028165103936092 2.6928966939098236 4.592655697223681 DHYEATAMHR ddPTM_A459_Selumetinib_30min_R1 4 DHYEATAMHR 10 0 B1AJY6;B1AJY5;B1AJY7;O75832-2;O75832 B1AJY6 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 ;;; 132.88 0.0013345999999999998 15566520.0 8377.91 10007.61 9788.64 9898.89 9549.39 8207.15 8943.19 9306.8 5136.22 7636.74 False True 8573.099002424926 8835.914368788332 8459.396453150715 8170.234686678732 8685.64936058174 8124.5935224959785 8268.597978096424 9059.953431253072 8715.79020533354 8616.989967146885 0.9949064621301292 1.02540613398369 0.9817113035297697 0.9481541370975886 1.0079679091767109 0.9428574889226731 0.9595691778244214 1.0514058233553745 1.011465748313894 1.0 13.072968288797851 -7.755689324264878 24.99994121606695 1.0235768403000913 0.9803005700029878 0.3215926200872383 0.027124687543123225 160.6428305969959 698448.30807267 0.013728934257682776 0.007647751712842144 1.7551356019599287e-08 7.755689324264878 -0.04327627029710357 DHYEATAMHR ddPTM_A459_Selumetinib_30min_R2 5 DHYEATAMHR 10 0 B1AJY6;B1AJY5;B1AJY7;O75832-2;O75832 B1AJY6 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 ;;;; 109.79 0.0055584 26367900.0 58401.3 45528.40000000001 58499.799999999996 54141.200000000004 61143.9 45206.100000000006 43417.6 51073.1 43340.0 51015.7 False True 55155.58954492728 49020.28188312045 54735.98655776633 46767.07516122059 53462.4566485986 51432.829934882284 45436.60443034226 51221.71426539313 52009.21102077854 49542.74418629296 1.1132929846907276 0.9894543123972317 1.1048234702531916 0.9439742575696823 1.0791177906408767 1.0381506067060422 0.9171192507925964 1.0338893233848094 1.049784622854379 1.0 15.596386161624004 -5.744392195730572 24.999499967843207 1.0105993357980754 1.0612166319868035 0.1954710577084584 0.0553036016912252 476.1673681725254 698288.9063396591 0.014750413136259641 0.025469798138139453 1.801390235350816e-06 5.744392195730572 0.05061729618872812 DHYQDPVPGIT(ph)PSSSSR ddPTM_A459_Selumetinib_30min_R1 2 DHYQDPVPGITPSSSSR 17 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 DHYQDPVPGIT(0.422)PS(0.09)S(0.032)S(0.032)S(0.422)R;DHYQDPVPGIT(0.925)PS(0.051)S(0.017)S(0.006)S(0.001)R 118.05 0.0036472 19651900.0 3975.7 4579.200000000001 3914.2 4355.7 4965.3 4113.0 4837.8 4219.6 2428.82 3606.51 True False 4068.3260746344563 4043.065135187675 3382.6731391615745 3595.058761615348 4516.189491694916 4071.6269543052053 4472.880851064877 4107.682500807523 4121.530146005856 4069.4406888822864 0.9997261013655082 0.9935186292881306 0.8312378525144841 0.8834282242857231 1.109781377090259 1.0005372397806145 1.0991389709364212 1.0093973139919974 1.0128001514473177 1.0 11.990614806223576 -6.2527834282129025 24.96956323772677 1.0402019350025526 0.9248920633904784 0.4676807605729544 0.05831316019423831 589.8950597055613 1701651.6665506703 0.01810429041460036 0.022987851943854432 5.587487592944316e-07 6.2527834282129025 -0.11530987161207429 DHYQDPVPGIT(ph)PSSSSR ddPTM_A459_Selumetinib_30min_R2 1 DHYQDPVPGITPSSSSR 17 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 DHYQDPVPGIT(0.998)PS(0.002)SSSR 160.76 8.5355e-05 0.0 37937.0 35747.0 42750.0 39090.0 37653.0 39584.0 31533.0 32860.0 30042.0 37674.0 True False 35828.6134138436 38488.67995527862 39999.511542680666 33765.87456598877 32922.69351790911 45036.336692224766 32999.34698145411 32955.61715973417 36051.23944361396 36586.25373119256 0.9792916672224624 1.0519983881942 1.093293449407695 0.9229115069849526 0.8998651176422583 1.230963329099417 0.9019602614661708 0.900765008679667 0.9853766310289795 1.0 15.159014077267154 DIAWTEDSKR ddPTM_A459_Selumetinib_30min_R2 1 DIAWTEDSKR 10 1 D6RD66;O75083 D6RD66 WDR1 WD repeat-containing protein 1 0 99.788 0.024516 8871200.0 33072.0 27982.0 37107.0 35576.0 32577.0 23374.0 32358.0 26068.0 28547.0 24509.0 False True 31233.990637705567 30128.129423688883 34719.57601904684 30730.487427976917 28484.386017924862 26593.556331953867 33862.71111616061 26143.85356421029 34257.19766982385 23801.36148797047 1.3122774784749875 1.2658153794654161 1.4587222683288343 1.2911230915722414 1.1967544811384532 1.11731240019167 1.4227216007485657 1.0984184067547458 1.4392957178999153 1.0 14.538756480635762 -11.800536801897112 1.96851932627385 5.295304597531053e-05 1.2840644349734573 0.3411182893403605 0.12037466147667336 1600037.2772038043 222689.5939841018 7111620.097269082 0.029181440523250366 1.5829354238670723e-12 11.800536801897112 1.284011481927482 DIDDDLEGEVTEECGK ddPTM_A459_Selumetinib_30min_R1 1 DIDDDLEGEVTEECGK 16 0 A0A0J9YYL3;A0A0J9YXJ8;A0A0J9YVP6;A0A0J9YXX5;Q9UHX1-4;Q9UHX1-6;Q9UHX1-3;Q9UHX1-5;Q9UHX1-2;Q9UHX1 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 120.03 0.022662 2462500.0 692.11 853.54 845.45 824.65 798.38 872.32 785.77 861.76 478.33 697.59 False True 708.2348163883729 753.6071400000196 730.6425337244274 680.6403580976878 726.166669965437 863.545252803189 726.4987362729437 838.9033254090178 811.6910741590491 787.1324716020184 0.8997657217049267 0.9574082726713509 0.9282332518151368 0.8647087785775225 0.9225469614885786 1.0970774094043545 0.9229688298773021 1.065771462459975 1.0312000882228216 1.0 9.620462646397328 -6.649779011474017 8.91951848369347 1.021083063612288 0.9140700435590435 0.5667127177741007 0.04762236294657566 0.20223093506083042 15.11752279722842 0.015277892622645268 0.01526623983222928 2.2398605902475934e-07 6.649779011474017 -0.10701302005324453 DIDDDLEGEVTEECGK ddPTM_A459_Selumetinib_30min_R2 1 DIDDDLEGEVTEECGK 16 0 A0A0J9YYL3;A0A0J9YXJ8;A0A0J9YVP6;A0A0J9YXX5;Q9UHX1-4;Q9UHX1-6;Q9UHX1-3;Q9UHX1-5;Q9UHX1-2;Q9UHX1 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 168.61 0.00017672 2686900.0 15969.0 19286.0 16861.0 17624.0 19603.0 14234.0 16464.0 18034.0 12966.0 16276.0 False True 15081.50690897194 20765.17418573596 15776.181616868753 15223.58079690423 17140.29588695648 16194.604296612944 17229.608622797095 18086.47595431059 15559.562300309532 15806.069589873403 0.9541592122708561 1.313746853236667 0.9981090825372679 0.9631477775257702 1.0844122752653123 1.0245813612631736 1.090062809405554 1.144274093661981 0.9844042639340395 1.0 13.948191044642844 -7.870382809780743 0.008372151132946417 8.445127932122515e-08 2.105258161466846 0.027914993744831862 0.10236063920490418 5905.012513825208 50.194972633403694 6298.790441325857 6316.072371259868 1.3477743603229413e-08 7.870382809780743 2.105258077015567 DIDEVSSLLR ddPTM_A459_Selumetinib_30min_R1 1 DIDEVSSLLR 10 0 P50990-2;P50990;H7C4C8;P50990-3 P50990-2 CCT8 T-complex protein 1 subunit theta 0 157.99 0.0066875 4662900.0 1632.1 2233.4 2064.9 1965.2 1979.6 1896.5 1638.0 1776.7 1179.6 1891.2 False True 1670.1247544862283 1971.9124897205093 1784.497921683802 1622.014711372795 1800.5455295267675 1877.4229318842265 1514.4443412386343 1729.5761444650514 2001.6950454247371 2133.953941847986 0.7826432997142921 0.924065159538003 0.8362401299713348 0.7600982755832791 0.8437602584653305 0.8797860605456154 0.7096893290616847 0.8105030340848187 0.9380216724318269 1.0 11.059313322781039 -8.413475177448618 3.4606120498190758 0.997247466605989 0.8199317219760971 0.5371432022368527 0.05720171715099803 0.1795787944207309 3.8442109380016123 0.05630162726768335 0.014961325539569572 3.859444700206618e-09 8.413475177448618 -0.17731574462989186 DIDEVSSLLR ddPTM_A459_Selumetinib_30min_R2 2 DIDEVSSLLR 10 0 P50990-2;P50990;H7C4C8;P50990-3 P50990-2 CCT8 T-complex protein 1 subunit theta 0 ; 213.53 0.0024338000000000003 10753100.0 32922.0 28567.0 37045.0 35552.0 40120.0 27219.0 27550.0 27906.0 25197.0 31978.0 False True 31092.327037208008 30757.9970426174 34661.565031546335 30709.756269379217 35079.76692264929 30968.17018051904 28831.12958928933 27987.201839913017 30237.10406300317 31054.712051177918 1.001211248907029 0.990445411051581 1.1161451110679872 0.9888919987011885 1.1296117273551953 0.9972132451102346 0.9283979043752155 0.9012223907853446 0.9736720151573991 1.0 14.922524570284846 -7.001357065354926 24.990280964451394 0.9454793098892071 1.0450612026386477 0.42891463963612575 0.051264197501540355 46.0839205276491 848646.0997341911 0.017838402452599076 0.015523362710854693 9.968801185201196e-08 7.001357065354926 0.09958189274944051 DIDHETVVEEQIIGENS(ph)PPDYSEYMTGK ddPTM_A459_Selumetinib_30min_R1 7 DIDHETVVEEQIIGENSPPDYSEYMTGK 28 0 P25490;A0A494C032;H0YJU4;H0YJV7 P25490 YY1 Transcriptional repressor protein YY1 1 DIDHETVVEEQIIGENS(0.995)PPDY(0.003)S(0.001)EYMTGK;DIDHETVVEEQIIGENS(0.943)PPDY(0.036)S(0.017)EY(0.003)MT(0.001)GK;DIDHETVVEEQIIGENS(1)PPDYSEYMTGK;DIDHETVVEEQIIGENS(0.999)PPDY(0.001)SEYMTGK;DIDHETVVEEQIIGENS(0.999)PPDY(0.001)SEYMTGK;DIDHETVVEEQIIGENS(1)PPDYSEYMTGK;DIDHETVVEEQIIGENS(0.98)PPDY(0.01)S(0.006)EY(0.001)MT(0.003)GK 178.46 1.4606999999999998e-26 126278700.0 11090.029999999999 14106.74 14503.68 15652.74 14131.43 12130.840000000002 13267.15 12126.830000000002 6351.7300000000005 9911.36 True False 11348.406121558066 12455.116322754502 12534.159919011525 12919.282797320071 12853.244651606608 12008.814763521461 12266.39819405626 11805.187074904656 10778.421897995648 11183.579600821937 1.0147382615065408 1.1136967560761237 1.1207645822175154 1.1552010410307778 1.1492961207753158 1.0737898948417977 1.0968221832260883 1.0555821567217203 0.963772091111462 1.0 13.449094414401833 -8.004645202039164 2.287945979778599 0.9813339605498466 1.1082089120680507 0.6038709694188166 0.03880970370018988 0.216582281260043 2.1049513181853685 0.032890217179491484 0.011202606747625705 9.893610255503416e-09 8.004645202039164 0.12687495151820416 DIDHETVVEEQIIGENS(ph)PPDYSEYMTGK ddPTM_A459_Selumetinib_30min_R2 5 DIDHETVVEEQIIGENSPPDYSEYMTGK 28 0 P25490;A0A494C032;H0YJU4;H0YJV7 P25490 YY1 Transcriptional repressor protein YY1 1 DIDHETVVEEQIIGENS(0.998)PPDY(0.002)SEYMTGK;DIDHETVVEEQIIGENS(0.998)PPDY(0.001)S(0.001)EYMTGK;DIDHETVVEEQIIGENS(1)PPDYSEYMTGK;DIDHETVVEEQIIGENS(0.999)PPDY(0.001)SEYMTGK;DIDHETVVEEQIIGENS(0.999)PPDY(0.001)SEYMTGK 162.1 7.499600000000002e-25 28279300.0 91285.0 77304.5 105668.0 118995.0 118517.0 91044.7 88195.0 90788.0 81547.2 105068.0 True False 86211.74514280818 83233.50657685508 98869.43592261922 102787.67572217545 103627.8349045769 103585.28100350128 92296.24225507713 91052.17804923751 97858.91861914229 102034.41384055169 0.8449281168756508 0.8157395475111308 0.9689812701538292 1.0073824296457554 1.0156165062751792 1.015199451876826 0.9045599301359999 0.8923673359022181 0.9590775791789777 1.0 16.63869629627561 -5.265107967674651 24.63852763772079 0.9687385461823337 0.8303338236699856 0.6445526099891552 0.041590412774843294 164.1680382522715 1102575.5298798764 0.012417868260702828 0.027577524713234214 5.431152936613622e-06 5.265107967674651 -0.13840472251234803 DIDIHEVR ddPTM_A459_Selumetinib_30min_R1 4 DIDIHEVR 8 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;Q5RI18;A0A1W2PRZ7;A0A1W2PQ74;A0A1W2PQL0;A0A1W2PP34;A0A1W2PPL4;A0A1W2PPH7 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 ;;; 109.48 0.017469 82082000.0 56082.9 73347.0 52062.4 65697.0 50151.7 52716.5 51555.0 41962.0 31967.199999999997 37666.799999999996 False True 57389.522451673096 64759.49914190479 44992.61203829274 54224.25223542569 45615.48759000179 52186.21987275231 47666.16484283137 40849.03144821434 54246.003608088846 42501.70068570205 1.3502876714526257 1.5236919487245473 1.0586073336455606 1.2758137053482004 1.0732626425310843 1.2278619215420763 1.1215119412590162 0.9611152210188217 1.2763254818727214 1.0 15.37523295072305 -5.263162435056775 24.98880746113053 1.1301092883367003 1.4369898215950256 0.5632147053071266 0.11004748358772229 97.15452763438506 1409020.5794375816 0.026905600936313005 0.06108841535330292 5.455537746098346e-06 5.263162435056775 0.3068805332583253 DIDIHEVR ddPTM_A459_Selumetinib_30min_R2 4 DIDIHEVR 8 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;Q5RI18;A0A1W2PRZ7;A0A1W2PQ74;A0A1W2PQL0;A0A1W2PP34;A0A1W2PPL4;A0A1W2PPH7 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 ;;; 128.12 0.006195 77882500.0 568771.0 606590.0 621079.0 631716.0 675807.0 456492.0 524288.0 508193.0 462989.0 614199.0 False True 537160.9847907128 653113.5025057343 581119.4533196873 545675.1910291158 590906.0828687645 519369.6293782103 548668.430856963 509671.75749412004 555599.7369935231 596465.4789893504 0.9005734677233577 1.09497284505445 0.9742717286913815 0.9148479002568707 0.9906794335692224 0.870745496048202 0.9198661954194323 0.8544865972087884 0.931486827929975 1.0 19.186079117416746 -5.627257181086403 4.487341603854048 0.9202764733352482 1.005796020899966 0.18421927574133068 0.061167450764559816 0.27420603991084447 9.525585482426045 0.01613423277506517 0.028948004321425514 2.3590808158305137e-06 5.627257181086403 0.08551954756471769 DIDIS(ph)SPEFK ddPTM_A459_Selumetinib_30min_R1 2 DIDISSPEFK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 DIDIS(0.5)S(0.5)PEFK;DIDIS(0.656)S(0.344)PEFK 214.04 0.00031852 647846000.0 20877.2 25967.0 26748.0 26658.0 21749.0 20818.9 19004.8 20733.6 13261.4 17844.0 True False 21363.598140040376 22926.771568269203 23115.768516246953 22002.680732635843 19781.806790097813 20609.480768048765 17571.252635147743 20183.67757577563 22503.627225665994 20134.45121527891 1.0610469543778147 1.1386837079955454 1.148070452434566 1.0927877048836194 0.9824855208910043 1.0235928731153785 0.8726958806711305 1.0024448821559817 1.1176677717736478 1.0 14.297378530264444 -6.174581628015624 4.164915074461397 0.9946529951638783 1.1183289703454788 0.4496312753808308 0.05985817341710524 0.21181540955061046 6.704466080698203 0.018799441293522057 0.024554746595945656 6.689880682736443e-07 6.174581628015624 0.12367597518160056 DIDIS(ph)SPEFK ddPTM_A459_Selumetinib_30min_R2 4 DIDISSPEFK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 DIDIS(0.638)S(0.362)PEFK;DIDIS(0.5)S(0.5)PEFK;DIDIS(0.66)S(0.34)PEFK;DIDIS(0.618)S(0.382)PEFK 216.84 6.502e-05 104158100.0 984414.0 913998.0 863004.0 887198.0 772107.0 675299.0 885915.0 789295.0 634640.0 811898.0 True False 929704.2108014711 984098.7076332194 807479.2622077118 766360.101898086 675108.0159358408 768315.3074960248 927111.8029072697 791591.7177751791 761585.7333231859 788456.3951756608 1.1791447396331176 1.2481333319821337 1.0241267204482662 0.9719752501054266 0.856240142215389 0.9744550392350501 1.1758567862217892 1.0039765326512695 0.9659199138761652 1.0 19.588671444793945 -5.325192275845962 5.12493033869623 0.9947819529025868 1.2136229637631386 0.5721043899751185 0.07528734160983504 0.15011752289939165 7.916966230323097 0.0218335229594911 0.047935647961524754 4.7294182636108106e-06 5.325192275845962 0.21884101086055185 DIDISS(ph)PEFK ddPTM_A459_Selumetinib_30min_R1 3 DIDISSPEFK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 DIDIS(0.034)S(0.966)PEFK;DIDIS(0.455)S(0.545)PEFK;DIDIS(0.121)S(0.879)PEFK 196.16 0.00017119 597642600.0 38103.5 39844.1 47617.4 46408.0 37627.0 36203.0 35756.7 36645.0 23677.4 32413.3 True False 38991.237413495524 35179.13424898046 41151.2186236555 38303.71398605165 34223.644493586406 35838.83068969396 33059.54333111567 35673.055560264394 40178.8184711255 36573.86278727862 1.0660956880676475 0.9618654297903889 1.1251537433439764 1.04729747056892 0.9357404956823516 0.9799028037629014 0.9039117230629157 0.9753701917608892 1.0985664463394003 1.0 15.158525386041436 -6.232926566799653 20.9632522282409 0.9769830240831242 1.0491612903584207 0.23184126035937902 0.060041207976510365 146.56490340457344 107756.02437881038 0.017988959442211613 0.023211140762805615 5.848889724332771e-07 6.232926566799653 0.07217826627529644 DIDISS(ph)PEFK ddPTM_A459_Selumetinib_30min_R2 5 DIDISSPEFK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 DIDIS(0.042)S(0.958)PEFK;DIDIS(0.142)S(0.858)PEFK;DIDIS(0.387)S(0.613)PEFK;DIDIS(0.204)S(0.796)PEFK;DIDIS(0.122)S(0.878)PEFK 205.07 5.9036e-05 83862100.0 1084685.0 1078720.0 963870.0 1044844.0 899233.0 715067.0 1013349.0 889741.0 722183.0 920445.0 True False 1024402.5500380887 1161454.355368513 901855.6535823079 902534.444743566 786263.3112949813 813560.9885180639 1060471.7364129506 892329.9990054488 866639.7794789791 893869.361246685 1.1460316176508705 1.2993558183363902 1.0089345184899103 1.0096939036872186 0.8796176996137054 0.910156476762315 1.186383360241707 0.9982778666458717 0.9695374033967014 1.0 19.769704471781154 -5.27974536982757 19.91603507289821 0.9954259011188945 1.2226933922383108 0.5416749348494927 0.08365802708857385 39.48355798003421 42957.059862071976 0.022848657657032735 0.047894356471333 5.251152490935183e-06 5.27974536982757 0.22726749111941624 DIDNNLITST(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 DIDNNLITSTPR 12 0 Q05D32;H0YMH7;Q05D32-2;H0YNU2;H0YNW9 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 DIDNNLIT(0.006)S(0.039)T(0.955)PR 130.66 0.0049956 9000900.0 41951.0 43127.0 45720.0 40769.0 44258.0 37375.0 36603.0 32645.0 34909.0 41466.0 True False 39619.53136315877 46434.70222483851 42778.424976172195 35216.19186955223 38697.914368459926 42523.06699353021 38305.112027468516 32739.99154532932 41891.775438956145 40268.76883839337 0.9838773944681517 1.1531194909680569 1.0623226438297773 0.8745286455337599 0.9609907500217452 1.0559813031330505 0.951236234243828 0.8130368146272726 1.040304351172896 1.0 15.297373744112818 -5.638756487767621 7.844957554861079 0.9531035057122887 1.0779483270265213 0.29205663019353845 0.07796035090392416 0.265243740644154 17.04016354622575 0.021093506077043005 0.036636191671759175 2.2974364772073595e-06 5.638756487767621 0.12484482131423258 DIDTHTHR ddPTM_A459_Selumetinib_30min_R2 2 DIDTHTHR 8 0 Q86XP3-2;Q86XP3;A0A0A0MSJ0 Q86XP3-2 DDX42 ATP-dependent RNA helicase DDX42 0 ; 96.668 0.029354 1710520.0 15696.0 14123.3 12822.900000000001 11105.3 10435.1 12684.1 27184.0 49365.0 20970.4 36078.0 False True 14823.679156066362 15206.511696432892 11997.888574517896 9592.738982288956 9124.149447022366 14431.219640204323 28448.109864074093 49508.6439771843 25165.06596193203 35036.334398098596 0.4230944649526703 0.43402119421654284 0.3424413192942072 0.27379402403493297 0.2604196358942598 0.4118929644930977 0.8119602222319797 1.413065745253051 0.7182562443889029 1.0 15.096564223486357 -7.359520371182928 3.2775025886468203 1.0575108392672181 0.34824557134910006 0.7757182113957005 0.16820479531007693 0.10776399701408662 2.2017468304113255 0.07319294091435195 0.04698836475122849 4.3699818058621095e-08 7.359520371182928 -0.7092652679181181 down DIEDVFYK ddPTM_A459_Selumetinib_30min_R2 2 DIEDVFYK 8 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 ; 141.47 0.03153 4398500.0 35903.0 30863.0 31281.0 37873.0 32929.0 28027.0 32212.0 31923.0 25995.0 29585.0 False True 33907.654991096504 33230.09285981381 29268.414516177632 32714.63206543089 28792.16463100495 31887.46484622533 33709.92182686709 32015.890644862837 31194.726360986115 28730.80417893861 1.1801846819154764 1.156601557438251 1.018711983621855 1.1386605074358713 1.0021357025610624 1.1098702510248821 1.1733024114785644 1.1143402198373684 1.0857589006803263 1.0 14.81031075420651 -5.047806292569306 12.282248785926031 1.0880520415817259 1.1743103859924209 0.28208092046784927 0.055658379493890534 1.715248249575819 440.6955761218366 0.014024117656200829 0.037298638220553716 8.957642122396099e-06 5.047806292569306 0.08625834441069502 DIEEHLQR ddPTM_A459_Selumetinib_30min_R1 1 DIEEHLQR 8 0 Q9UNE7;H3BTA3;Q9UNE7-2 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 114.89 0.011338 0.0 2815.6 2663.2 3354.8 3485.8 3180.7 2600.5 3066.1 2968.2 1538.4 2595.6 False True 2881.1980017961055 2351.3913059119104 2899.2365865973256 2877.0704665699627 2893.006246598195 2574.341331065083 2834.8216084687274 2889.4736939275963 2610.5524397095733 2928.770543285022 0.9837568219203825 0.8028595177259941 0.9899159199222995 0.9823475154673365 0.9877886313870419 0.8789836189002374 0.9679220569082486 0.9865824758967464 0.8913475470773743 1.0 11.516079453286642 -4.7549177215396465 0.007951918132556001 1.8549409894592712 2.959069442552108e-07 0.05371555422275509 0.06107516450418868 30632.36151209561 37.789849820104706 4155.734276630848 4669.975239241414 1.7582566896859915e-05 4.7549177215396465 -1.854940693552327 DIEREDIEFICK ddPTM_A459_Selumetinib_30min_R2 2 DIEREDIEFICK 12 1 P50991-2;P50991 P50991-2 CCT4 T-complex protein 1 subunit delta 0 ; 153.74 0.0012989000000000002 6819500.0 37287.0 44962.0 44600.0 41581.0 45294.0 32674.0 26685.0 31542.0 29220.0 53152.0 False True 35214.73781168747 48410.44082438352 41730.4845568084 35917.59606877412 39603.76278650239 37174.546914959385 27925.905375324346 31633.781997940798 35064.816475014995 51617.36365451901 0.6822265865297535 0.9378712393837122 0.8084582706725466 0.6958432884944443 0.7672565970547229 0.7201946066787318 0.5410176614643798 0.6128515630838755 0.6793221116387863 1.0 15.65556883753151 -6.002945823533774 1.4417667928643803 0.6843174648021139 0.8220650378845771 0.0533324719371292 0.12948230015558282 0.7845587752186776 3.302409632837122 0.04454581561135972 0.07885642773037636 9.932399433270911e-07 6.002945823533774 0.13774757308246321 DIIDYES(ph)DVEPETK ddPTM_A459_Selumetinib_30min_R1 1 DIIDYESDVEPETK 14 0 F5GYN7;Q5FWF4-2;Q5FWF4-3;Q5FWF4 F5GYN7 ZRANB3 DNA annealing helicase and endonuclease ZRANB3;DNA annealing helicase ZRANB3;Endonuclease ZRANB3 1 DIIDYES(0.999)DVEPET(0.001)K 154.07 0.00035119 3691500.0 1628.1 1874.7 1786.1 1899.3 1242.1 1520.9 1565.7 1667.1 846.67 1425.5 True False 1666.0315622688736 1655.209252475615 1543.557430345023 1567.6229092765882 1129.7522743105667 1505.601126866711 1447.5979884476976 1622.8830924960237 1436.7371516698558 1608.4768105458454 1.0357821457826903 1.0290538487240675 0.9596392190579411 0.9746008764307934 0.7023739894187092 0.9360415499902526 0.8999806394202521 1.0089564747565676 0.8932283898965825 1.0 10.65147942142882 -5.561734683885832 2.0834827485631338 0.9070472785623727 1.0321955234470805 0.24621095352971367 0.08105400788893308 0.4599827271311154 3.957011480624348 0.024365848323628134 0.05887730508042756 2.7432495467384228e-06 5.561734683885832 0.12514824488470788 DIIDYES(ph)DVEPETKR ddPTM_A459_Selumetinib_30min_R1 2 DIIDYESDVEPETKR 15 1 F5GYN7;Q5FWF4-2;Q5FWF4-3;Q5FWF4 F5GYN7 ZRANB3 DNA annealing helicase and endonuclease ZRANB3;DNA annealing helicase ZRANB3;Endonuclease ZRANB3 1 DIIDYES(1)DVEPETKR;DIIDYES(0.999)DVEPET(0.001)KR 132.51 0.00031737 19463900.0 8385.8 10297.4 11805.2 11619.8 10515.7 9078.5 9482.2 10151.2 5429.1 7957.3 True False 8581.172824073656 9091.775620868615 10202.118681321908 9590.620060660287 9564.556791697622 8987.178532618482 8766.950019836982 9881.957200255321 9212.786174224686 8978.696965665706 0.9557258538614042 1.0125941053178784 1.1362582700289958 1.0681527728727853 1.0652499831848907 1.0009446322762878 0.9764167399079802 1.1006003697467082 1.026071623694856 1.0 13.132290373551163 -9.420180831735957 16.074163617677282 1.0 1.0407723507650262 0.04207615254083541 0.05293082086449231 0.0 0.0 0.05351054562477177 0.012978213629139236 3.8003112583765843e-10 9.420180831735957 0.040772350765026166 DIIDYES(ph)DVEPETKR ddPTM_A459_Selumetinib_30min_R2 1 DIIDYESDVEPETKR 15 1 F5GYN7;Q5FWF4-2;Q5FWF4-3;Q5FWF4 F5GYN7 ZRANB3 DNA annealing helicase and endonuclease ZRANB3;DNA annealing helicase ZRANB3;Endonuclease ZRANB3 1 DIIDY(0.001)ES(0.995)DVEPET(0.003)KR 74.14699999999998 0.021115 7064100.0 25914.0 24414.0 28853.0 29398.0 27924.0 27828.0 21968.0 26920.0 19593.0 29525.0 True False 24473.803621961226 26286.475296617125 26996.629392771116 25393.94168562136 24415.937476272647 31661.05440256747 22989.555528766174 26998.332743154107 23512.147474160458 28672.536534837323 0.8535625577536675 0.9167823455270127 0.9415500913206626 0.8856538260843282 0.8515443845230477 1.104229281008992 0.801797061129688 0.9416094983557158 0.8200232806606783 1.0 14.807381918741015 -4.761027459955767 22.106587424646044 0.9161235513164118 0.8535624237584433 0.049655151663501984 0.08433278269907876 8.274794294381648 441466.7620640487 0.019754508604539006 0.11256996628106845 1.7336943747265992e-05 4.761027459955767 -0.0625611275579685 DIIHDPGR ddPTM_A459_Selumetinib_30min_R1 1 DIIHDPGR 8 0 G3V1A1;E9PKZ0;P62917;E9PKU4 G3V1A1 RPL8 60S ribosomal protein L8 0 96.948 0.029036000000000006 42458000.0 13512.0 15284.0 16483.0 16505.0 16115.0 12614.0 14299.0 13091.0 8012.2 11266.0 False True 13826.803310224816 13494.542174661165 14244.699134638044 13622.711587221645 14657.401095334322 12487.11461259564 13220.41491780905 12743.784154439112 13596.118212065176 12712.100840132936 1.087688296695436 1.061550906838153 1.120562156781088 1.071633379764724 1.1530274405202912 0.9823014126172599 1.0399866303822365 1.002492374368692 1.0695414064952458 1.0 13.633914853730417 -6.7700410614276825 24.999711095457695 1.0203402821454806 1.096507390846519 0.5993323934747454 0.03267655513632874 133.6046199195701 388302.19421808183 0.010874617295881362 0.009737367453515618 1.6980830954769636e-07 6.7700410614276825 0.07616710870103849 DIIHDPGR ddPTM_A459_Selumetinib_30min_R2 3 DIIHDPGR 8 0 G3V1A1;E9PKZ0;P62917;E9PKU4 G3V1A1 RPL8 60S ribosomal protein L8 0 ;; 109.11 0.017689 104429000.0 366560.0 350156.0 386920.0 401370.0 403230.0 276541.0 306037.0 299474.0 290480.0 373540.0 False True 346188.06265594345 377011.839271003 362025.98844664363 346702.71359813126 352572.6424780629 314632.01256074454 320268.32690081105 300345.4197594101 348584.1166893343 362754.9296265241 0.9543304153367753 1.0393017667855187 0.9979905409400475 0.9557491443467923 0.9719306718755154 0.8673404187357985 0.882877945257821 0.8279568249248384 0.9609355744613052 1.0 18.46863569424066 -6.652143009109566 5.17567598160829 0.8957604209622329 0.9881454504820629 0.34988199162916467 0.05066856789191228 0.20060640707573357 8.345678539621865 0.01654096270919133 0.016450448226612 2.2277014672291695e-07 6.652143009109566 0.09238502951983008 DIIIFVGT(ph)PVQK ddPTM_A459_Selumetinib_30min_R1 2 DIIIFVGTPVQK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 DIIIFVGT(1)PVQK;DIIIFVGT(1)PVQK 143.56 0.0019068 14670900.0 5634.1 11946.3 5660.6 6906.6 6454.6 6015.1 9559.6 6866.599999999999 3688.7 7187.7 True False 5765.363567949795 10547.621642315808 4891.921611450106 5700.491962938811 5870.7825696521895 5954.593555273822 8838.511675521882 6684.475462139762 6259.454488011382 8110.311309126888 0.710868343791166 1.3005199480377663 0.603173099649703 0.7028696859667765 0.72386648870624 0.734200368927005 1.0897869808740286 0.8241946834540654 0.7717896698943411 1.0 12.985541577096468 -10.548900273992173 15.249062126447006 1.0000000000000002 0.834188796222216 0.061942223002598995 0.198690286703957 0.0 0.0 0.19253140442184025 0.04669572451057404 2.8255287198603556e-11 10.548900273992173 -0.16581120377778424 DIIRQPS(ph)EEEIIK ddPTM_A459_Selumetinib_30min_R1 3 DIIRQPSEEEIIK 13 1 Q15121-2;Q15121;B1AKZ5 Q15121-2 PEA15 Astrocytic phosphoprotein PEA-15 1 DIIRQPS(1)EEEIIK;DIIRQPS(1)EEEIIK;DIIRQPS(1)EEEIIK 79.514 0.02141 42535300.0 3212.42 2733.28 8637.93 12841.5 6151.6 4796.35 3297.69 3038.31 1682.4 2247.14 True False 3287.2631357187997 2413.2663069326027 7464.946550753141 10598.973089809562 5595.18886615319 4748.103073737363 3048.9425883145486 2957.7241489782236 2854.9099223656985 2535.582307997189 1.2964529391733095 0.951760193041731 2.9440758153299975 4.180094275141673 2.206668207340794 1.8725888166840081 1.202462479209698 1.1664871377472563 1.12593857172822 1.0 11.308101391412146 -7.085084159113417 2.442161535173102 1.1211323469105439 2.3709164212484812 0.3169347912357957 0.8252344328708063 0.4222656781537716 4.951976199892757 0.40828987472203204 0.3065259155198475 8.220833283095284e-08 7.085084159113417 1.2497840743379374 DIISDT(ph)SGDFR ddPTM_A459_Selumetinib_30min_R2 1 DIISDTSGDFR 11 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 DIIS(0.385)DT(0.53)S(0.085)GDFR 103.43 0.031092 1483600.0 17266.0 12564.0 18061.0 16051.0 18764.0 16042.0 15008.0 17609.0 14852.0 13474.0 True False 16306.424841274322 13527.618400372641 16898.97492332995 13864.82611048058 16406.698567711643 18251.639885223056 15705.901737787814 17660.23927467312 17822.814999552444 13084.970610343707 1.2461949917093467 1.0338287187041153 1.2914797768037218 1.0595993314284096 1.2538582665781535 1.394855244901741 1.200300879955531 1.3496583065087397 1.3620829217196297 1.0 13.675623063556413 -6.501858922610595 23.569939707282575 1.2844091462190712 1.158254625269119 0.1226872275783466 0.1269444343873514 608.2800905486358 682077.081845071 0.036816900604737246 0.04124878606684626 3.148771003240632e-07 6.501858922610595 -0.12615452094995216 DIISDTSGDFR ddPTM_A459_Selumetinib_30min_R1 2 DIISDTSGDFR 11 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ; 180.09 0.00068902 55906000.0 6590.2 8576.1 4214.8 4112.4 6241.9 5663.4 7343.3 6683.6 3241.7 6388.6 False True 6743.738837703052 7572.006225079276 3642.45331023918 3394.246539308714 5677.321247096947 5606.43133795577 6789.388968875252 6506.329216607539 5500.928135599669 7208.639040233736 0.9355079093382362 1.0504071826620076 0.5052900124294579 0.4708581634292314 0.7875718586282361 0.7777378374287395 0.9418406069414055 0.9025738673130421 0.7631021757223823 1.0 12.815511195273901 -7.0845465491972375 3.6337464336767664 0.8932687163051818 0.7398756185564537 0.1483737617445745 0.17192675047181213 0.5556571741471287 13.811318278456161 0.07629652690915185 0.059075024652018374 8.231016092920341e-08 7.0845465491972375 -0.1533930977487281 DIISDTSGDFRK ddPTM_A459_Selumetinib_30min_R1 2 DIISDTSGDFRK 12 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ; 160.72 0.00064324 41671500.0 5204.4 5935.1 5297.4 5168.8 5402.1 5222.4 4558.7 4960.4 3332.38 4657.799999999999 False True 5325.652394000447 5240.215732846869 4578.042176535315 4266.166110392685 4913.481008818221 5169.86739755981 4214.833588769575 4828.834078349993 5654.805472594507 5255.674000814059 1.0133148275892967 0.9970587468011153 0.8710666178736002 0.8117257862135081 0.9348907500840359 0.9836735301236421 0.8019587189229647 0.9187849317902991 1.0759429659675668 1.0 12.359660075543976 -8.247402292419475 22.523371436080616 1.0379714454306574 0.9132598369024085 0.3203633933866592 0.07060510536840198 224.99357542389737 361021.3682910169 0.05100848301170129 0.01899151761451438 5.657150173481162e-09 8.247402292419475 -0.12471160852824892 DIISDTSGDFRK ddPTM_A459_Selumetinib_30min_R2 4 DIISDTSGDFRK 12 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;;; 155.47 0.0005767999999999999 72371000.0 211555.0 170972.0 193198.0 203811.0 182635.0 125067.0 182339.0 173532.0 132051.0 162747.0 False True 199797.6200217647 184085.0026383725 180767.85101807796 176051.59020641405 159690.7585223842 142293.84400481184 190818.1247978741 174036.94939023082 158464.8898132172 158048.0712425123 1.2641572810793182 1.16474058298319 1.143752338114294 1.1139116651178664 1.0103935927022565 0.900320028496097 1.2073423186865644 1.1011646521341274 1.0026372898285187 1.0 17.27000390369478 -5.30348284511183 1.098906152624636 1.0468490133923605 1.267190818318387 0.45944518617897456 0.07756971715626496 0.8621535197932695 1.50092504949355 0.02787989752446324 0.18012841014006944 4.971840123990858e-06 5.30348284511183 0.22034180492602662 DIISIAEDEDLR ddPTM_A459_Selumetinib_30min_R2 2 DIISIAEDEDLR 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 ; 176.95 0.001435 9104500.0 20050.3 19049.1 24607.0 24343.0 25103.0 19121.800000000003 21727.0 22724.2 20522.0 21669.0 False True 18935.984593710335 20510.10471748952 23023.812410075876 21027.44140598274 21949.336716332607 21755.65437958223 22737.348551233754 22790.323659806185 24626.973432589228 21043.35966717661 0.8998555788240717 0.9746592294138821 1.0941129541205519 0.999243549440506 1.0430528709999258 1.033848906432781 1.0804999254325072 1.0830173518040698 1.1702966551962866 1.0 14.361077435331444 -3.380017576166406 0.6349802564183554 1.073551251214527 1.2763172372605723e-18 0.5323544190214448 0.04862931713171195 13.67681317258842 1.0372354158035144 0.02139962261311709 15.899833724679906 0.0004168525128498293 3.380017576166406 -1.073551251214527 DIKEES(ph)DEEEEDDEESGR ddPTM_A459_Selumetinib_30min_R1 2 DIKEESDEEEEDDEESGR 18 1 Q96EV2;A8MTF7;Q96EV2-2;H7BXM6;H7C0H2 Q96EV2 RBM33 RNA-binding protein 33 1 DIKEES(0.994)DEEEEDDEES(0.006)GR;DIKEES(0.997)DEEEEDDEES(0.003)GR 120.15 0.00052772 47882000.0 3959.5 5216.9 4304.5 4716.9 3245.4 4673.3 4263.0 3874.2 2912.4 4260.1 True False 4051.748646154172 4606.10292272899 3719.972542926011 3893.1819621790873 2951.854143021906 4626.290845016898 3941.438477839009 3771.443630824842 4942.130086720077 4806.925331888011 0.8428981867631322 0.9582222740538922 0.7738777463940596 0.8099110540271209 0.6140836271035875 0.9624220318812056 0.8199500108088708 0.7845854408858762 1.0281270761447343 1.0 12.230898678287359 -8.265543905980815 24.870567184442063 1.0140635720059117 0.8212105937082566 0.40958994260895154 0.09283934705135083 345.70008238865336 2094654.8725161985 0.08003448056378894 0.02360875186207965 5.425703961774703e-09 8.265543905980815 -0.19285297829765513 DIKEES(ph)DEEEEDDEESGR ddPTM_A459_Selumetinib_30min_R2 3 DIKEESDEEEEDDEESGR 18 1 Q96EV2;A8MTF7;Q96EV2-2;H7BXM6;H7C0H2 Q96EV2 RBM33 RNA-binding protein 33 1 DIKEES(1)DEEEEDDEESGR;DIKEES(1)DEEEEDDEESGR;DIKEES(1)DEEEEDDEESGR 112.56 0.0006751 198071000.0 118086.0 94401.0 85319.0 83800.0 76738.4 60684.8 85316.1 78797.7 48405.6 84050.5 True False 111523.25285571165 101641.25315294306 79829.66842830334 72386.29543693678 67097.83614199972 69043.58035823367 89283.46770064498 79026.98826133853 58088.07256546838 81623.7436755748 1.3663089664078225 1.2452412567221947 0.978020179343865 0.8868289075865771 0.822038209968531 0.8458761782926449 1.0938418612054213 0.9681862740263734 0.7116565591054937 1.0 16.31670126091643 -5.209541404948915 2.280258198754037 0.90457994747467 1.3629561283115126 0.7258913359719898 0.09869078300634879 0.17848406886065493 1.7012116947686715 0.02819950085232043 0.11142312681629062 6.172464417840233e-06 5.209541404948915 0.4583761808368426 DIKEES(ph)DEEEEDDEESGRLR ddPTM_A459_Selumetinib_30min_R1 2 DIKEESDEEEEDDEESGRLR 20 2 Q96EV2;A8MTF7;Q96EV2-2;H7BXM6;H7C0H2 Q96EV2 RBM33 RNA-binding protein 33 1 DIKEES(1)DEEEEDDEESGRLR;DIKEES(1)DEEEEDDEESGRLR 112.41 0.0003707 16289400.0 4081.5 3133.8999999999996 5615.8 5628.799999999999 4209.9800000000005 4428.8 4047.6000000000004 4241.8 2809.17 3259.28 True False 4176.591008783495 2766.981531089416 4853.2052053813195 4645.835745662117 3829.1880523323375 4384.250293028662 3742.286273258544 4129.29368469176 4766.956316340968 3677.6403360756685 1.1356714162103863 0.7523795907791252 1.319651940341744 1.263265387887166 1.0412078676563523 1.1921367758618293 1.0175781020641779 1.1228106359900438 1.296199704353821 1.0 11.844564679384197 -5.266196864124589 24.998159730297786 1.1569839247349636 0.9440255076115899 0.2751459160231222 0.13801434359624684 455.5150101577293 2393512.15724235 0.034778708147732616 0.07634072941287547 5.417552590260692e-06 5.266196864124589 -0.2129584171233737 DILETHLR ddPTM_A459_Selumetinib_30min_R1 1 DILETHLR 8 0 P78527-2;P78527 P78527-2 PRKDC DNA-dependent protein kinase catalytic subunit 0 170.3 2.9999e-10 0.0 2492.3 4704.3 3169.0 3377.1 3346.8 3702.9 3110.7 3073.1 1270.8 2600.1 False True 2550.365740828399 4153.518369030262 2738.667206070978 2787.352881018252 3044.0825309255324 3665.652187964195 2876.0573945610627 2991.591405164377 2156.454784440282 2933.848162118733 0.8692902972138152 1.4157236978585563 0.9334727139025486 0.9500671905956146 1.0375733039733017 1.2494348669076918 0.980302059150895 1.0196817421539444 0.7350260358678405 1.0 11.518578492610434 -7.96900755168449 2.797530358186616 0.8693575051512138 1.0737856914931778 0.16752107310561293 0.16519649979074985 0.44765211389800663 6.825285184254533 0.11789884461138297 0.043703947963065544 1.0739707375502634e-08 7.96900755168449 0.20442818634196402 DILETHLR ddPTM_A459_Selumetinib_30min_R2 2 DILETHLR 8 0 P78527-2;P78527 P78527-2 PRKDC DNA-dependent protein kinase catalytic subunit 0 ; 136.27 0.0036604 4209600.0 52103.0 41341.0 54908.0 56296.0 60085.0 43474.0 45512.0 51922.0 41721.0 50306.0 False True 49207.32384483468 44511.72176773362 51375.27905931021 48628.38768398327 52536.58513328472 49462.148882320595 47628.398180317105 52073.08442385017 50066.36578213898 48853.53506931504 1.007241825489551 0.9111259134999933 1.0516184547631453 0.9953913798661177 1.0753896326794785 1.0124579278069035 0.9749222469313701 1.065902075458145 1.0248258536685857 1.0 15.576175339746081 -5.2735456288194404 24.998672154037877 1.0259137851956943 0.9591838655201195 0.33598848364619915 0.03703013940501471 707.5912220950353 1461134.4053589804 0.009236866072043829 0.019479253644806554 5.326652573128044e-06 5.2735456288194404 -0.06672991967557484 DINAYNCEEPTEKLPFPIIDDR ddPTM_A459_Selumetinib_30min_R2 1 DINAYNCEEPTEKLPFPIIDDR 22 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 88.071 0.0014385 2578800.0 3643.9 4948.0 4877.9 6393.2 6438.8 3342.9 3689.2 3367.5 1118.4 4409.4 False True 3441.3866256874494 5327.495689672384 4564.061224655957 5522.435131114852 5629.900380397659 3803.354131175176 3860.7551100111145 3377.298867480365 1342.111250706939 4282.089165002936 0.803670006176784 1.2441346932271857 1.0658491798717198 1.2896590702148691 1.314755523170849 0.8882005919586142 0.9016054923761653 0.7887035363678723 0.3134244054691511 1.0 12.064099121620504 -7.36233146138402 1.568375290468895 0.6650825209172943 1.1435716368379365 0.42310964592591715 0.21596125645585895 0.35553961471937356 1.6963832133849295 0.1282887024129262 0.0707926283608425 4.3417872464845995e-08 7.36233146138402 0.47848911592064225 DINTFLGT(ph)PVQK ddPTM_A459_Selumetinib_30min_R2 1 DINTFLGTPVQK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 DINT(0.002)FLGT(0.998)PVQK 140.77 0.006655 0.0 98324.0 88607.0 85369.0 90327.0 96101.0 91651.0 89821.0 110690.0 86417.0 89004.0 True False 92859.54570215783 95402.8719835894 79876.4514827395 78024.30677723393 84027.93322615956 104275.09332505797 93997.85447693492 111012.08957428393 103702.81469272319 86434.2232598361 1.0743377125401603 1.1037627040020017 0.9241299160243182 0.9027015438396372 0.972160448223815 1.2064097922369146 1.0875073660853207 1.2843534121960296 1.199788819539394 1.0 16.399315033967135 -6.758065072393293 24.99925644965953 1.1691274445688522 0.9923261537774569 0.4319436303017661 0.09116305262189531 81.47221626490503 603604.340158072 0.03177622962763376 0.030547451049617366 1.7455605877384905e-07 6.758065072393293 -0.17680129079139528 DINTFVGT(ph)PVEK ddPTM_A459_Selumetinib_30min_R1 2 DINTFVGTPVEK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 DINT(0.001)FVGT(0.999)PVEK;DINT(0.009)FVGT(0.991)PVEK 143.93 0.0018355 29270000.0 5907.5 11352.7 5748.5 6788.1 7126.8 7071.6 9458.5 7198.5 3515.2 7986.400000000001 True False 6045.133256006003 10023.520606272963 4967.885274250247 5602.6857634183125 6482.182198338736 7000.466124499074 8745.037729917958 7007.572395976621 5965.037659950012 9011.532234123713 0.6708219089662764 1.11229925675871 0.5512808638067671 0.6217239885357988 0.7193207581051356 0.7768341656694749 0.9704273926695143 0.7776227409409074 0.6619337871713284 1.0 13.137556713523441 -7.009985015264318 23.66590974483834 0.8396311472565943 0.7403899441142171 0.09922244938874292 0.16483058975589318 722.8086442715913 1713161.9021089745 0.06182982832083009 0.05136003761215497 9.772709397680383e-08 7.009985015264318 -0.09924120314237717 DINTFVGT(ph)PVEK ddPTM_A459_Selumetinib_30min_R2 3 DINTFVGTPVEK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 DINTFVGT(1)PVEK;DINT(0.002)FVGT(0.998)PVEK;DINTFVGT(1)PVEK 190.18 0.00031475 50385700.0 230455.0 207440.0 222050.0 210985.0 223680.0 220341.0 215326.0 226519.0 211304.0 238601.0 True False 217647.2336844593 223349.9809752701 207763.5447497602 182248.479030574 195579.31867542857 250690.97269355046 225339.0856603743 227178.13278776064 253570.70432705534 231711.96917015084 0.939300781327513 0.9639121439223522 0.8966457170677928 0.7865302758561653 0.8440622181748871 1.0819077391270322 0.9724965286316444 0.9804333095151381 1.0943358050738121 1.0 17.821973043527002 -6.75648843133396 24.999961888357685 1.0212781272448748 0.8854689671538521 0.5875772359944156 0.058475298597632994 101.17984726611093 510910.285258148 0.021432175331135925 0.02078638326637747 1.751909100657777e-07 6.75648843133396 -0.13580916009102262 DINVSVGSQQPDT(ph)KDSPVCPHFTTNGNENSSIEK ddPTM_A459_Selumetinib_30min_R2 1 DINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEK 34 1 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851;A0A494BZW2 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 DINVSVGS(0.007)QQPDT(0.491)KDS(0.491)PVCPHFT(0.008)T(0.002)NGNENSSIEK 78.415 3.3635e-06 5196800.0 14383.0 8382.8 16989.0 16607.0 16851.0 8367.1 8321.4 12353.0 9440.7 12457.0 True False 13583.650439710915 9025.733805049646 15895.946236224601 14345.097951327098 14734.026730148635 9519.59207602854 8708.361588541278 12388.945184850756 11329.103795197598 12097.334042827042 1.1228631359291235 0.746092798057547 1.3140040756045666 1.185806550479842 1.21795650826762 0.7869165257673495 0.7198579089997758 1.024105405454735 0.9364959052209559 1.0 13.562401527300413 -6.762860730315059 24.99855842334941 0.884130655804565 1.1114484817723993 0.3210201201499219 0.16239270258477648 49.92468334682562 878057.3606577753 0.05861928149134975 0.054499505643476415 1.7263914229524313e-07 6.762860730315059 0.22731782596783434 DIS(ph)LDSELHDLR ddPTM_A459_Selumetinib_30min_R1 2 DISLDSELHDLR 12 0 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 DIS(0.999)LDS(0.001)ELHDLR;DIS(1)LDSELHDLR 122.33 0.0023609 13780300.0 6447.5 7018.4 7252.8 8176.1 8209.3 6060.5 7477.799999999999 6577.4 3396.3 5820.1 True False 6597.714205348909 6196.682465234361 6267.909596778666 6748.297619405208 7466.77026446963 5999.536872493727 6913.743525588676 6402.945985593751 5763.273044062419 6567.166527574805 1.0046515765430704 0.9435854015906523 0.9544313472881201 1.0275813154836038 1.1369850654947593 0.9135655152495885 1.0527742058250895 0.9749936991407924 0.8775889906039498 1.0 12.681055323648144 -10.003985574616214 6.841189067357155 0.9999981921423459 0.9900702324021877 0.0015684484289494316 0.07021305178239474 0.0 0.0 0.0684862956147313 0.01661036651334193 9.908648565898958e-11 10.003985574616214 -0.009927959740158143 DIS(ph)SSLNSLADSNAR ddPTM_A459_Selumetinib_30min_R1 2 DISSSLNSLADSNAR 15 0 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 DIS(0.813)S(0.154)S(0.031)LNS(0.001)LADS(0.001)NAR;DIS(0.91)S(0.083)S(0.006)LNS(0.001)LADSNAR 108.96 0.0038647 10679300.0 3277.5 3864.2000000000003 4238.6 4644.799999999999 4125.7 3549.5 3943.8 3614.0 2087.1 2919.8 True False 3353.859373095163 3411.7776675821556 3663.0214009632223 3833.6728736944633 3752.531163451497 3513.795252688139 3646.3159908284038 3518.1449800735586 3541.656264247173 3294.5847712604423 1.0179915242587743 1.0355713707366156 1.1118309757626372 1.1636285419445367 1.1389997295519136 1.0665366037444017 1.1067604095776222 1.0678568694796664 1.0749932116307956 1.0 11.6858809331452 -10.155668927648229 12.253052756991973 0.9999983236283094 1.0895203591428895 0.2739621455331307 0.04239183788345935 0.0 0.0 0.04536817490154088 0.011003398656502895 6.987648851180618e-11 10.155668927648229 0.08952203551458005 DIS(ph)SSLNSLADSNAR ddPTM_A459_Selumetinib_30min_R2 1 DISSSLNSLADSNAR 15 0 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 DIS(0.896)S(0.077)S(0.025)LNS(0.002)LADSNAR 117.53 0.0025818 0.0 8950.3 6362.3 7635.5 7547.4 7080.9 6768.7 6849.8 7240.2 7125.4 8174.7 True False 8452.878156889697 6850.267951981119 7144.2402429038175 6519.4311000087955 6191.334037950831 7701.02698485908 7168.3292726212 7261.267783320366 8550.679100310464 7938.675170578653 1.064771888918786 0.8628981290692865 0.8999285257798337 0.8212240657194684 0.7798951216566204 0.970064503130155 0.9029629149190517 0.9146699704040278 1.0770914436705945 1.0 12.954682550933207 -8.172164752518889 5.282645528649875 1.0374185839768932 0.8950073645283523 0.34031701576058315 0.07577387056724966 0.2336598568206753 10.259479325472645 0.05497278077340007 0.01970500456936462 6.727214065032508e-09 8.172164752518889 -0.14241121944854096 DIS(ph)TNYY(ph)AS(ph)QKK ddPTM_A459_Selumetinib_30min_R1 1 DISTNYYASQKK 12 1 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 3 DIS(0.569)T(0.278)NY(0.313)Y(0.841)AS(0.999)QKK 60.158 0.043833 0.0 456.43 627.85 601.65 511.79 666.44 435.44 587.1 494.63 280.11 492.52 True False 467.06393094182306 554.3410301204541 519.9492346268867 422.4154839881352 606.1606196695384 431.05986894788657 542.8145743230784 481.51080561532484 475.326211575045 555.7397395510632 0.8404364447990096 0.9974831574367186 0.9355984422616804 0.7600958756870081 1.090727505215312 0.775650611734379 0.9767424132050986 0.8664322008073386 0.8553036210061608 1.0 9.11826559724571 DISEGGESPVVQS(ph)DEEEVQVDTALATSHTDR ddPTM_A459_Selumetinib_30min_R1 1 DISEGGESPVVQSDEEEVQVDTALATSHTDR 31 0 D6RJC6;A0A087WYP9;A6NFV8;Q96EV8-3;Q96EV8 D6RJC6 DTNBP1 Dysbindin 1 DISEGGESPVVQS(1)DEEEVQVDTALATSHTDR 145.77 6.623799999999998e-20 9375000.0 468.95 476.75 502.6 412.36 604.75 474.55 554.34 438.29 261.64 315.53 True False 479.8756225821437 420.9318883649378 434.3496805841825 340.34906695587534 550.0504692772842 469.77645785692556 512.5256874983058 426.6651254334368 443.98397057047123 356.03134902246984 1.3478465418837537 1.1822888336115929 1.219975942502664 0.9559525246592688 1.5449495410657486 1.3194805995223668 1.4395521318712845 1.1983920140878075 1.247036171925553 1.0 8.475860467730566 -8.943587034479167 1.6334651522457453 1.000289978144054 1.2760532886963625 0.23141844747833928 0.15038475734276724 3.3763661311441635 11.313721167227472 0.14797406924737977 0.04212883468129402 1.1387095567226856e-09 8.943587034479167 0.2757633105523085 DISEGGESPVVQS(ph)DEEEVQVDTALATSHTDR ddPTM_A459_Selumetinib_30min_R2 2 DISEGGESPVVQSDEEEVQVDTALATSHTDR 31 0 D6RJC6;A0A087WYP9;A6NFV8;Q96EV8-3;Q96EV8 D6RJC6 DTNBP1 Dysbindin 1 DISEGGES(0.001)PVVQS(0.998)DEEEVQVDT(0.001)ALATSHTDR;DISEGGES(0.002)PVVQS(0.998)DEEEVQVDTALATSHTDR 98.225 2.5064e-08 5075400.0 9914.3 9188.4 13579.1 12508.1 13865.2 8958.1 10239.2 11256.7 8486.0 8759.9 True False 9363.302896087456 9893.120734637374 12705.435489806197 10804.475202323976 12123.329619539301 10191.9969614647 10715.343088589885 11289.455133352993 10183.437118650822 8506.978926046446 1.100661348462865 1.1629417235708526 1.493530852757261 1.2700719369649685 1.4251039910796544 1.1980747866036332 1.2595944085134534 1.3270815916549685 1.197068572424864 1.0 13.054431164842194 -8.61375621235351 3.8641781948478 1.0000699278134881 1.283521289647777 0.36969573390437527 0.11053721373400367 0.46493883492629373 16.419564193967492 0.10854110648512436 0.028473013792946148 2.4335696901229227e-09 8.61375621235351 0.2834513618342889 DISGPS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 DISGPSPSK 9 0 S4R3D6;Q96GX9-3;Q96GX9 S4R3D6 APIP Methylthioribulose-1-phosphate dehydratase 1 DIS(0.007)GPS(0.849)PS(0.144)K;DIS(0.008)GPS(0.974)PS(0.017)K;DIS(0.001)GPS(0.932)PS(0.067)K 124.39 0.005326300000000001 184080000.0 16397.8 20794.9 17150.7 17823.300000000003 14411.0 16404.800000000003 17123.6 16109.4 10173.300000000001 15462.2 True False 16779.836835435497 18360.223440713267 14821.7291420516 14710.795239777499 13107.527594468691 16239.782606366645 15831.953065710542 15682.126381294136 17263.34707156618 17446.92398458225 0.9617647701258828 1.0523473052864847 0.8495325110116534 0.8431741465015465 0.7512801457753666 0.9308106472360201 0.9074352063264076 0.8988476361307212 0.9894779782855536 1.0 14.090685081120803 -9.740922161515073 11.157445851707548 0.999999186438317 0.9055129011266796 0.10280335354666648 0.0795427642188066 0.0 0.0 0.08311417525345541 0.02015814844447613 1.8158410863262797e-10 9.740922161515073 -0.09448628531163739 DISGPSPS(ph)KK ddPTM_A459_Selumetinib_30min_R1 1 DISGPSPSKK 10 1 S4R3D6;Q96GX9-3;Q96GX9 S4R3D6 APIP Methylthioribulose-1-phosphate dehydratase 1 DIS(0.036)GPS(0.245)PS(0.719)KK 145.14 0.0016387 103120000.0 4056.9 4838.0 4385.8 4311.4 3793.7 3780.9 3852.3 3826.7 2230.4 3416.3 True False 4151.417876646761 4271.564710874818 3790.2324494749455 3558.49492500136 3450.560504832135 3742.8675787825323 3561.7179094954763 3725.203485126589 3784.8258980292753 3854.8153825799873 1.0769433720242811 1.1081113586342246 0.9832461670157036 0.9231297926957261 0.895129899197069 0.9709589713937145 0.9239658857830063 0.9663766264814865 0.9818436221700795 1.0 11.912446051932296 -5.371815106775659 3.88700598423262 0.9478310473421656 1.0926843445125936 0.7639794540822988 0.03071844690633566 0.0993733052238231 2.620120758167254 0.008299213289562861 0.01891495207970815 4.248003767309824e-06 5.371815106775659 0.14485329717042794 DISGPSPS(ph)KK ddPTM_A459_Selumetinib_30min_R2 2 DISGPSPSKK 10 1 S4R3D6;Q96GX9-3;Q96GX9 S4R3D6 APIP Methylthioribulose-1-phosphate dehydratase 1 DISGPS(0.393)PS(0.607)KK;DIS(0.003)GPS(0.365)PS(0.632)KK 150.51 0.0012701 57977000.0 238438.0 192548.0 185451.0 196645.0 185396.0 141393.0 181965.0 175727.0 128603.0 168549.0 True False 225186.5705029402 207315.81246059752 173519.28456378164 169861.61176845364 162104.89701873105 160868.60231213958 190426.73305680702 176238.33647682893 154327.19346804768 163682.5524271055 1.3757518267148536 1.2665724561750324 1.0600963999572088 1.037750262625578 0.9903614931159078 0.9828084907447966 1.163390540000357 1.0767081394048705 0.94284449490593 1.0 17.320541021854197 -5.139072727977301 2.2457156942039047 1.0323894378188272 1.3789755701111417 0.8108618290552676 0.05723363388003635 0.15355728167245747 1.368795066193704 0.016531178895834213 0.07716572863230671 7.25984372201302e-06 5.139072727977301 0.3465861322923145 DISMEIDS(ph)PENMMR ddPTM_A459_Selumetinib_30min_R2 1 DISMEIDSPENMMR 14 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 DISMEIDS(1)PENMMR 136.3 0.00059627 1631600.0 4183.4 4572.8 5672.1 6065.9 5486.8 3527.9 4500.1 3439.2 3879.6 4704.5 True False 3950.9033754770617 4923.519056130533 5307.163261315533 5239.713955738841 4797.499131385645 4013.8362019123797 4709.363566778985 3449.207502609789 4655.628405081046 4568.668861241056 0.8647821707970795 1.0776703686931435 1.1616432318699212 1.1468797837791858 1.0500868583595329 0.8785570422851878 1.0307955577020544 0.7549699064144537 1.0190338907198382 1.0 12.157558163943389 -6.665927126216183 6.068910074297461 0.9276561869839146 1.0737929295365287 0.2470961619160661 0.10648417530294724 0.2715167833100153 14.335736723262517 0.035370446102167344 0.03521200707545767 2.1581065049181724e-07 6.665927126216183 0.1461367425526141 DITDPLSLNTCTDEGHVVLAS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 4 DITDPLSLNTCTDEGHVVLASPLK 24 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 DITDPLSLNTCTDEGHVVLAS(1)PLK;DITDPLS(0.022)LNT(0.049)CT(0.243)DEGHVVLAS(0.686)PLK;DITDPLSLNTCTDEGHVVLAS(1)PLK;DITDPLSLNTCTDEGHVVLAS(1)PLK 190.15 1.5351e-26 477918000.0 28277.0 30922.500000000004 33429.0 32751.100000000002 29495.2 29398.8 29510.8 28965.1 16087.200000000003 26421.199999999997 True False 28935.79908253607 27302.079324519764 28889.525412353036 27031.735199288407 26827.364367800492 29103.074763974666 27284.77659671861 28196.851456095366 27298.8034373998 29812.61838428194 0.9705889871716817 0.9157893806105335 0.9690368366833694 0.9067212698613654 0.89986609099537 0.9761998892159917 0.9152089979155913 0.9458025824045548 0.9156794980407527 1.0 14.863635469542311 -10.649720202524378 4.481320483757654 1.0000080034709888 0.9345089895983251 0.33910939483142444 0.02722015022565025 36730860.5063706 0.7721665571368155 3033.417467155499 0.00623244653831841 2.2401639161545e-11 10.649720202524378 -0.06549901387266377 DITDPLSLNTCTDEGHVVLAS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 3 DITDPLSLNTCTDEGHVVLASPLK 24 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 DITDPLSLNTCT(0.001)DEGHVVLAS(0.999)PLK;DITDPLSLNTCT(0.002)DEGHVVLAS(0.998)PLK;DITDPLSLNTCTDEGHVVLAS(1)PLK 133.02 6.7351e-08 179103200.0 240859.0 212259.0 224824.0 253112.0 254171.0 194197.0 224673.0 228091.0 167144.0 233631.0 True False 227473.0210149713 228538.5827797431 210359.06860986256 218637.70895744552 222239.76666242987 220945.8740051528 235120.73968110382 228754.7070475025 200577.47039356251 226885.46598376206 1.00258965477873 1.007286129099602 0.9271597354099258 0.9636479269813306 0.979524032968843 0.9738211879158696 1.0362970526191888 1.0082386990089274 0.8840472417387795 1.0 17.791604669058636 DITQDNS(ph)ELK ddPTM_A459_Selumetinib_30min_R1 2 DITQDNSELK 10 0 Q6NXT6-2;Q6NXT6 Q6NXT6-2 TAPT1 Transmembrane anterior posterior transformation protein 1 homolog 1 DIT(0.001)QDNS(0.999)ELK;DITQDNS(1)ELK 95.099 0.023129 38677000.0 2818.9 3163.7 2944.3 3726.8 2929.4 2563.3999999999996 3447.7 3127.0 1235.66 2278.9 True False 2884.574885375424 2793.2925332357718 2544.4802318822294 3075.9843407002504 2664.4362872275756 2537.6145233809775 3187.637213240805 3044.061802072503 2096.8247709643356 2571.4190133657867 1.121783291786328 1.086284467337577 0.9895237682604296 1.1962205788756408 1.036173518737437 0.9868537605854591 1.2396413018150771 1.1838062121536792 0.8154348863664019 1.0 11.328349001504137 -8.259589196592316 24.999575860651614 0.9077174415893348 1.1018519368351576 0.43010250450888 0.09079398153582521 152.64495841712628 2062606.948022497 0.06939700551331081 0.02318230210937162 5.5006093588429e-09 8.259589196592316 0.19413449524582282 DITQDNS(ph)ELK ddPTM_A459_Selumetinib_30min_R2 2 DITQDNSELK 10 0 Q6NXT6-2;Q6NXT6 Q6NXT6-2 TAPT1 Transmembrane anterior posterior transformation protein 1 homolog 1 DIT(0.004)QDNS(0.996)ELK;DITQDNS(1)ELK 133.12 0.0023254 7684200.0 55808.0 81848.8 66098.0 79552.0 66423.0 49909.0 51941.0 51177.3 47680.4 59972.2 True False 52706.414777124846 88126.33977462753 61845.32664206101 68716.88036514563 58078.348910845794 56783.51172120666 54356.35941913891 51326.2174701419 57217.812301687336 58240.64675951129 0.9049764676337038 1.5131415030214375 1.0618928546146518 1.179878387149323 0.9972133233798783 0.9749807888583129 0.9333062464705882 0.8812782880327441 0.9824377901906298 1.0 15.829738756232327 -6.303638379456687 1.6299166438488741 0.9414363781539661 1.1981472203282417 0.3121155890011609 0.1459351746075634 0.39807070579278697 2.1002995982054786 0.050546949436047206 0.06587409685908475 4.97005987239836e-07 6.303638379456687 0.25671084217427564 DITS(ph)DTSGDFR ddPTM_A459_Selumetinib_30min_R2 1 DITSDTSGDFR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 1 DIT(0.06)S(0.43)DT(0.43)S(0.079)GDFR 85.92399999999998 0.040665 0.0 12836.0 11305.0 16442.0 15297.0 15377.0 10517.0 13179.0 11045.0 11885.0 12120.0 True False 12122.626506579234 12172.057148695692 15384.139620696038 13213.522211203132 13445.203787875827 11965.621286179461 13791.849613693079 11077.139121401817 14262.332094645893 11770.064108458198 1.0299541612409466 1.0341538530744803 1.3070565698652987 1.1226380833140608 1.1423220522829474 1.0166147929118527 1.1717735338231494 0.941128189220445 1.2117463391211865 1.0 13.522834557929446 -6.729695162339373 24.982591827887184 1.0710430936058606 1.131790176087863 0.07487975548275716 0.10278516124047694 560.1549217662778 440838.64406899945 0.033379608980570616 0.033376897904672215 1.8633946217273031e-07 6.729695162339373 0.060747082482002446 DITSDT(ph)SGDFR ddPTM_A459_Selumetinib_30min_R1 3 DITSDTSGDFR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 1 DITS(0.005)DT(0.955)S(0.04)GDFR;DITS(0.002)DT(0.499)S(0.499)GDFR;DITS(0.004)DT(0.991)S(0.005)GDFR 132.56 0.004647699999999999 15151100.0 4851.9 4633.5 5157.099999999999 5415.200000000001 5856.299999999999 4055.96 5863.400000000001 6491.0 2550.59 4093.2000000000003 True False 4964.939829846047 4091.007665944288 4456.794145922576 4469.536975893529 5326.59869901374 4015.1607249170265 5421.119017349576 6318.837594260506 4328.164942276939 4618.602091144344 1.0749875680708167 0.8857675082658323 0.96496603473765 0.9677250578618517 1.1532924018778108 0.8693454525159574 1.1737575375336986 1.368127729898225 0.9371157889041175 1.0 12.173240542938068 -7.284696701157207 24.727873460601266 1.150427597307512 0.9872728603262015 0.18162017506101436 0.13282105103883934 974.8775086707252 1036513.8840682575 0.053588947895388685 0.03615529123498905 5.191624805801359e-08 7.284696701157207 -0.16315473698131044 DITSDTS(ph)GDFR ddPTM_A459_Selumetinib_30min_R2 1 DITSDTSGDFR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 1 DIT(0.011)S(0.028)DT(0.134)S(0.827)GDFR 112.5 0.0076375 3487400.0 34157.0 31487.0 34347.0 42106.0 41204.0 30766.0 30204.0 33455.0 29560.0 32632.0 True False 32258.690681304695 33901.951653337564 32137.15141418606 36371.090163098575 36027.58515156634 35003.73723405887 31608.545848090587 33552.34851122659 35472.825975408705 31689.82937188185 1.0179509110871892 1.0698054336454874 1.0141156342956241 1.1477212368764085 1.1368816388621312 1.1045732314708336 0.9974350280388892 1.0587734038415915 1.1193757327984695 1.0 14.951732271361657 -5.708777296068059 24.999960953129765 1.08299857812031 1.037542148737647 0.14947463633818192 0.050647309874369446 208.40852504337235 98934.36185028277 0.014377031369064517 0.024901734113337258 1.9553418877945077e-06 5.708777296068059 -0.04545642938266292 DITSDTSGDFR ddPTM_A459_Selumetinib_30min_R1 4 DITSDTSGDFR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 0 ;;; 210.64 0.00024 225879400.0 12842.9 15489.0 15631.600000000002 16495.699999999997 15665.1 12866.6 14845.8 13909.099999999999 7840.1 11199.999999999998 False True 13142.114582066772 13675.540679359261 13508.91457823261 13615.035657639024 14248.194470898043 12737.17368593808 13725.969353577852 13540.185484875798 13304.077081751851 12637.6290972385 1.0399193140538132 1.0821286630692113 1.0689437452460524 1.0773409753427643 1.1274420511369079 1.0078768405001957 1.0861190218485814 1.0714181735112418 1.0527352068481721 1.0 13.625438209323198 -8.709594416896055 2.33286697345517 1.000030983800152 1.0710918622025116 0.3422114559635724 0.029225458868512057 0.8339621508764218 8.065511250655293 0.02714066845804243 0.007382872611686945 1.9516663899121894e-09 8.709594416896055 0.07106087840235964 DITSDTSGDFR ddPTM_A459_Selumetinib_30min_R2 4 DITSDTSGDFR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 0 ;;; 232.72 2.6051e-06 332485000.0 583920.0 513490.0 595450.0 618410.0 619610.0 472630.0 494350.0 512590.0 420614.0 572310.0 False True 551468.0640169638 552873.031869415 557139.3952769412 534181.491183246 541769.052416319 537730.4923920319 517338.25453594106 514081.5520361578 504748.5529370968 555785.9232600435 0.9922310748394766 0.9947589687526763 1.002435239829319 0.9611281409394583 0.9747800902161997 0.9675136952693858 0.9308228814098385 0.9249632466773131 0.9081708114815511 1.0 19.08416976939251 -6.6550420490459015 1.0470771848044114 0.9353625509491515 0.9934701159017578 0.4077207298955903 0.0247786621542938 0.4450916511305045 1.0477480720997558 0.012736054274115026 0.012868047882094912 2.2128804448152287e-07 6.6550420490459015 0.05810756495260627 DIYLS(ph)PDRTGSSFGK ddPTM_A459_Selumetinib_30min_R2 1 DIYLSPDRTGSSFGK 15 1 Q15696 Q15696 ZRSR2 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 1 DIYLS(0.887)PDRT(0.071)GS(0.014)S(0.028)FGK 126.77 0.0060161 0.0 37814.0 43701.0 40738.0 44763.0 41246.0 26178.0 20696.0 25823.0 18587.0 37681.0 True False 35712.44926143559 47052.72617913757 38116.9614321807 38666.20217951793 36064.30873608155 29783.78187977614 21658.40500834599 25898.140654772225 22304.91936417192 36593.05162300439 0.9759352575827482 1.2858377230708373 1.041644786143452 1.0566542134247763 0.985550729893474 0.8139190518085251 0.5918720644421559 0.707733832137991 0.6095397452490634 1.0 15.159282111646167 -6.706023737129149 1.9091769020329343 0.7010363947518932 1.1026896543118838 0.6204686076042911 0.12919289756784955 0.19585950550494832 1.4707582271064725 0.04915392598852437 0.04685937532360917 1.967778734358075e-07 6.706023737129149 0.40165325955999065 DKAIT(ph)PPLPESTVPFSNGVLK ddPTM_A459_Selumetinib_30min_R1 1 DKAITPPLPESTVPFSNGVLK 21 1 Q92667-2;Q92667;I3NI36 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 DKAIT(0.979)PPLPES(0.01)T(0.01)VPFSNGVLK 70.704 0.00826 46383000.0 4980.8 6641.8 7154.7 6211.4 5522.4 7137.2 6069.3 7087.6 3322.8 5474.6 True False 5096.842949050308 5864.174968310949 6183.131037953941 5126.695592418574 5022.899895058909 7065.406248059104 5611.487814578534 6899.6138242305915 5638.548912290026 6177.31823711981 0.8250899101204026 0.9493075705688647 1.0009409909949598 0.8299225320159171 0.8131198203252759 1.1437659477542745 0.9084019309315857 1.1169270481760956 0.912782650310568 1.0 12.592764940638848 -6.7471560913922115 24.99996702742555 1.016935136926407 0.8908507682777905 0.3576110466792344 0.08866475756077509 280.64647224942 491213.219715814 0.02861567602233721 0.0284863884925592 1.7899624013768242e-07 6.7471560913922115 -0.1260843686486165 DKAIT(ph)PPLPESTVPFSNGVLK ddPTM_A459_Selumetinib_30min_R2 1 DKAITPPLPESTVPFSNGVLK 21 1 Q92667-2;Q92667;I3NI36 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 DKAIT(0.923)PPLPES(0.032)T(0.045)VPFSNGVLK 70.89699999999998 0.0080509 4089600.0 48218.0 31128.0 35623.0 42780.0 35369.0 25782.0 39337.0 30869.0 24750.0 36507.0 True False 45538.2365919475 33515.41750770451 33331.05496338982 36953.290200383744 30925.630017128173 29333.23647430623 41166.24844478673 30958.82367936193 29700.691572779644 35452.94805342272 1.2844696729684548 0.9453492402719622 0.9401490367786763 1.0423192492962847 0.8723006608795268 0.8273849731792424 1.1611516306839944 0.873236934562148 0.8377495583166958 1.0 15.11361797782427 -4.761440931799351 10.305767791975978 0.9441591743894461 1.2856535128603888 0.5227849776252541 0.09747216833849262 0.057215649242926256 149.23783741836084 0.024109955830293663 0.13605971036651018 1.7320445893501674e-05 4.761440931799351 0.3414943384709427 DKALQLSNS(ph)PGASSAFLK ddPTM_A459_Selumetinib_30min_R1 1 DKALQLSNSPGASSAFLK 18 1 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 DKALQLS(0.003)NS(0.985)PGAS(0.006)S(0.006)AFLK 84.156 0.0044885 15015000.0 1674.8 2128.4 5102.2 4812.8 3468.6 2579.4 2362.3 2637.0 1752.8 2330.3 True False 1713.8195814064916 1879.2059385336847 4409.349264378462 3972.334827445041 3154.86574243107 2553.453577907814 2184.1098091013587 2567.058193816817 2974.373580553135 2629.416704044185 0.6517869833147955 0.7146854797276386 1.6769305746010683 1.5107285282455898 1.1998348293668006 0.9711102747542696 0.8306442283347786 0.9762842800338732 1.1311914068159634 1.0 11.360527079801374 -6.765769617242209 23.828689139127608 0.9709136244520749 1.1757913346675053 0.07009066909853534 0.2995563565488243 174.1432132052598 958273.8746845718 0.1158580448303591 0.10585317459400424 1.714866761760609e-07 6.765769617242209 0.20487771021543044 DKAPVQPQQS(ph)PAAAPGGTDEKPSGK ddPTM_A459_Selumetinib_30min_R1 3 DKAPVQPQQSPAAAPGGTDEKPSGK 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 DKAPVQPQQS(1)PAAAPGGTDEKPSGK;DKAPVQPQQS(1)PAAAPGGTDEKPSGK;DKAPVQPQQS(1)PAAAPGGTDEKPSGK 129.26 2.4872e-08 406657000.0 21410.2 25824.9 26370.1 28528.1 24479.1 23329.0 23900.8 23667.1 12323.0 20513.0 True False 21909.016003002907 22801.308702329716 22789.18526059083 23546.20287376056 22264.969727136133 23094.331441037222 22097.943413355533 23039.371626424712 20911.230963690254 23146.043363540488 0.9465555584983419 0.9851061083833534 0.9845823280746213 1.0172884628242942 0.9619341577060977 0.9977658418032379 0.9547179648062046 0.9953913619083682 0.9034473251108439 1.0 14.498477976591813 -9.949188328267274 6.3813769283872785 0.9999999994703282 0.9746221633781011 0.06407169457574602 0.030671281476568828 0.0 0.0 0.028248181590301208 0.006851190378143539 1.1241174038963705e-10 9.949188328267274 -0.025377836092227102 DKAPVQPQQS(ph)PAAAPGGTDEKPSGK ddPTM_A459_Selumetinib_30min_R2 3 DKAPVQPQQSPAAAPGGTDEKPSGK 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 DKAPVQPQQS(1)PAAAPGGTDEKPSGK;DKAPVQPQQS(1)PAAAPGGTDEKPSGK;DKAPVQPQQS(1)PAAAPGGTDEKPSGK 145.65 1.2285e-09 45775200.0 269845.0 261774.0 271108.0 281629.0 279599.0 220920.0 241251.0 250931.0 189810.0 247858.0 True False 254848.09517512264 281851.2240639243 253665.20644007224 243270.64436287704 244473.27397322588 251349.72468791134 252469.64952978716 251661.16766613637 227777.30373451696 240701.69552757742 1.0587714997874804 1.1709565379095235 1.053857164919761 1.0106727492287453 1.015669097957045 1.0442374497487241 1.048890199865092 1.045531345820135 0.9463053562429945 1.0 17.87688677877773 -5.483093108888707 6.280293045726992 1.021071327283136 1.11511014875998 0.514837868950187 0.037927477568370616 0.1545463166740682 16.993894675030443 0.009686222281725226 0.01979951386946468 3.2878113555728e-06 5.483093108888707 0.09403882147684395 DKAS(ph)PEPEKDFSEK ddPTM_A459_Selumetinib_30min_R1 1 DKASPEPEKDFSEK 14 2 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 DKAS(1)PEPEKDFSEK 96.143 0.013569 35171000.0 5478.7 6599.4 6805.0 6332.8 5389.5 5871.9 5598.6 6408.4 3559.7 5634.7 True False 5606.343050305555 5826.739180022177 5880.91837718934 5226.895361378811 4902.020676593509 5812.834017258628 5176.29309454128 6238.428414583118 6040.550909798605 6357.96863162587 0.88178211865004 0.916446669937746 0.9249681333651787 0.8221014704884099 0.7710042248729931 0.9142596250545136 0.8141425971800665 0.9811983631929019 0.9500756074434902 1.0 12.634350183316423 -7.77609063464223 24.99539399432343 0.9742278000894385 0.8647267178115342 0.5350491446556224 0.048481006950368326 211.47549366307348 360777.0177742821 0.027932482035509104 0.013510438730192158 1.6745933620098886e-08 7.77609063464223 -0.10950108227790434 DKDDDGGEDDDANCNLICGDEYGPETR ddPTM_A459_Selumetinib_30min_R1 2 DKDDDGGEDDDANCNLICGDEYGPETR 27 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ; 112.74 1.3924e-09 55378000.0 1701.6399999999999 2340.88 1985.79 2266.5 1942.52 1825.69 1902.7399999999998 1979.27 1045.94 1988.49 False True 1741.2849011849432 2066.8086813544132 1716.1306251636768 1870.6983224742737 1766.8194089797598 1807.325216193889 1759.214789895238 1926.7733300249567 1774.8837875648937 2243.732061032838 0.7760663278053764 0.9211477240303894 0.764855418776565 0.8337440797691108 0.7874467008179467 0.8054995726013464 0.7840574284459945 0.8587359264002412 0.7910408815693781 1.0 11.131684689085276 -10.72151380972526 3.423445293510924 1.0003214836338865 0.8153902655802736 0.6101926423199235 0.044669676349266114 29787508.811176088 45838794.77785456 106432.99327692259 0.010246274814744246 1.8988304620021433e-11 10.72151380972526 -0.1849312180536129 DKDDDGGEDDDANCNLICGDEYGPETR ddPTM_A459_Selumetinib_30min_R2 4 DKDDDGGEDDDANCNLICGDEYGPETR 27 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ;;; 142.2 4.1157e-12 132181800.0 162893.0 133422.0 159405.0 159193.0 143610.0 119424.0 147381.0 146782.0 104820.0 143374.0 False True 153840.0591723445 143655.03838065232 149149.05584704128 137510.63877675784 125568.42791031075 135873.57197686567 154234.50852991114 147209.11131893194 125786.92891550531 139234.42008961114 1.1048996295121076 1.0317494645950052 1.0712082238791893 0.9876195748742023 0.9018490386895355 0.9758619448367549 1.1077326169107176 1.05727528598308 0.9034183417760419 1.0 17.08715637782283 -5.761341022102457 24.99999965651017 0.9934995485696683 1.065532155143432 0.26014667631162314 0.0606153290616073 4.297422133040291 1091583.8574565777 0.018142480600684838 0.02900462053649541 1.7324430930465522e-06 5.761341022102457 0.07203260657376376 DKDDQEWESPS(ph)PPKPTVFISGVIAR ddPTM_A459_Selumetinib_30min_R1 5 DKDDQEWESPSPPKPTVFISGVIAR 25 2 P51397 P51397 DAP Death-associated protein 1 1 DKDDQEWES(0.002)PS(0.998)PPKPTVFISGVIAR;DKDDQEWES(0.051)PS(0.943)PPKPT(0.004)VFIS(0.002)GVIAR;DKDDQEWES(0.011)PS(0.982)PPKPT(0.005)VFIS(0.002)GVIAR;DKDDQEWES(0.003)PS(0.997)PPKPTVFISGVIAR;DKDDQEWES(0.005)PS(0.987)PPKPT(0.007)VFIS(0.001)GVIAR 110.13 2.2522e-07 703555000.0 19236.399999999998 22862.600000000002 19586.399999999998 19385.9 16254.000000000002 18256.799999999996 18561.300000000003 19994.5 12608.9 19043.9 True False 19684.570692481393 20185.836163465618 16926.674460394017 16000.51648341231 14783.828569876785 18073.1531678481 17161.206197211643 19464.180908710787 21396.38238238044 21488.370068294676 0.9160569475450944 0.9393842389772084 0.7877132796297436 0.7446128502329035 0.6879920870168649 0.8410667309994997 0.7986276363758454 0.9058007120525856 0.9957191873733616 1.0 14.391268435438992 -8.027324502027833 2.5137016849042197 0.9999287480963485 0.813008115855852 0.5190076043554478 0.06996956746351723 0.2707620639838418 3.1929946989970497 0.0638870804296047 0.021711078994129378 9.390214176427573e-09 8.027324502027833 -0.1869206322404965 DKDDQEWESPS(ph)PPKPTVFISGVIAR ddPTM_A459_Selumetinib_30min_R2 3 DKDDQEWESPSPPKPTVFISGVIAR 25 2 P51397 P51397 DAP Death-associated protein 1 1 DKDDQEWES(0.011)PS(0.989)PPKPT(0.001)VFISGVIAR;DKDDQEWES(0.019)PS(0.69)PPKPT(0.217)VFIS(0.074)GVIAR;DKDDQEWES(0.008)PS(0.988)PPKPT(0.004)VFIS(0.001)GVIAR 108.14 2.8561e-07 56181100.0 163077.0 139337.0 144921.0 138807.0 122194.7 111139.1 125127.7 127660.4 83109.4 131023.0 True False 154013.8331889548 150023.6998609296 135596.9406380542 119901.24714456913 106843.5093515217 126447.50220469988 130946.38598583367 128031.87062868307 99733.60227065739 127240.02555136273 1.2104196971163317 1.1790605920647967 1.0656783512143986 0.9423233501015671 0.8397004707327129 0.9937714304659351 1.0291288878512115 1.006223238905282 0.7838225577092337 1.0 16.95719304113782 -5.468540214428379 2.318984203063608 0.9437601355896386 1.2018207870545805 0.656609717071075 0.07344432354987143 0.19364636310061717 2.0234012805007326 0.021645465668198322 0.05537351493105945 3.399850227046008e-06 5.468540214428379 0.25806065146494195 DKDQPPS(ph)PSPPPQSEALSSTSR ddPTM_A459_Selumetinib_30min_R2 1 DKDQPPSPSPPPQSEALSSTSR 22 1 H3BU99;H3BPL8;H3BR21;H3BUX9;Q7L1V2 H3BU99 MON1B Vacuolar fusion protein MON1 homolog B 1 DKDQPPS(0.972)PS(0.028)PPPQSEALSSTSR 110.12 0.00011888 0.0 13995.0 9614.8 12164.0 16856.0 15187.0 15397.0 15307.0 16451.0 11753.0 12236.0 True False 13217.213926423845 10352.224243545268 11381.381483161822 14560.183721778123 13279.073286497372 17517.79698995009 16018.805830245077 16498.869686390346 14103.92840625773 11882.714887054006 1.1123059041687309 0.8712002553241281 0.957809860065028 1.2253246720277005 1.117511731343876 1.4742251376438729 1.348076258877276 1.3884764418917055 1.1869281170436643 1.0 13.536576871127336 -5.972286027264574 1.8063981582610489 1.2942932394799185 0.9661445136444888 0.39990910456419915 0.1438024242115705 0.29900946082909097 1.9705476908697406 0.04580652835538754 0.07681353719774626 1.0658938900391839e-06 5.972286027264574 -0.32814872583542964 DKDQPPSPS(ph)PPPQSEALSSTSR ddPTM_A459_Selumetinib_30min_R1 2 DKDQPPSPSPPPQSEALSSTSR 22 1 H3BU99;H3BPL8;H3BR21;H3BUX9;Q7L1V2 H3BU99 MON1B Vacuolar fusion protein MON1 homolog B 1 DKDQPPS(0.03)PS(0.97)PPPQSEALSSTSR;DKDQPPS(0.119)PS(0.881)PPPQSEALSSTSR 117.96 1.8254e-05 37490000.0 3775.42 5488.299999999999 3279.7 3288.63 3666.38 3596.7000000000003 4205.46 4511.6 2238.93 3937.2 True False 3863.3799403114995 4845.727284558554 2834.3347541025537 2714.332505730671 3334.756576351963 3560.5204635423133 3888.238766364729 4391.937712257849 3799.3006850227216 4442.57797157566 0.8696256914408786 1.0907467050803181 0.6379932490182707 0.6109813993355692 0.7506354638429039 0.8014536798955708 0.8752212772048834 0.9886011546354807 0.8552018015961157 1.0 12.117181381843082 -7.425469424038582 2.9973467450406885 0.9413004614284401 0.7893712797383942 0.2226132141166266 0.1292777828019699 0.4747931652846827 8.206856147561142 0.06924878674587326 0.04214238771043886 3.7543138532016535e-08 7.425469424038582 -0.151929181690046 DKDQPPSPS(ph)PPPQSEALSSTSR ddPTM_A459_Selumetinib_30min_R2 1 DKDQPPSPSPPPQSEALSSTSR 22 1 H3BU99;H3BPL8;H3BR21;H3BUX9;Q7L1V2 H3BU99 MON1B Vacuolar fusion protein MON1 homolog B 1 DKDQPPS(0.303)PS(0.696)PPPQSEALSSTS(0.001)R 60.51 0.008220700000000001 14842000.0 34665.0 24159.0 29930.0 33229.0 36433.0 34119.0 34041.0 35344.0 34557.0 31803.0 True False 32738.458074989827 26011.91761657135 28004.33638532006 28703.15287677775 31855.960824847483 38818.582548555365 35623.973950961845 35446.84518848583 41469.365603254366 30884.764755882505 1.0600196677474856 0.8422248905624887 0.9067362697002955 0.9293628461687009 1.031445797843741 1.256884514270478 1.153448123453059 1.147712973327226 1.342712691226047 1.0 14.914607721514393 -6.549063676654576 3.6967389957188597 1.187191813638405 0.9288189045588601 0.5906868249871 0.09639526207802923 0.14819470392863693 4.373544121862955 0.031196257764266648 0.03245685078670889 2.824465818790045e-07 6.549063676654576 -0.2583729090795449 DKDVTLS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 DKDVTLSPVK 10 1 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 DKDVTLS(1)PVK 86.49799999999998 0.019234 131150000.0 5091.8 6621.2 4184.4 5060.0 5708.5 5777.6 6502.0 6186.4 3438.4 6709.6 True False 5210.429033081903 5845.986825887633 3616.1814632639334 4176.365987963741 5192.167182917535 5719.48258964108 6011.548905209765 6022.316575740751 5834.713669200077 7570.842517038523 0.6882231431119584 0.7721712362568599 0.47764584392365234 0.5516382065225424 0.6858110139303952 0.7554618362182448 0.7940396186660207 0.795461873917897 0.7706822135143864 1.0 12.886238143329894 -6.887276254615984 1.732365391759665 0.8273523665186645 0.6234970864261322 0.5198046333783306 0.09413918269984366 0.3351961647342474 2.064098470655603 0.043933023572405486 0.03640416047868796 1.2963543979387677e-07 6.887276254615984 -0.2038552800925323 DKDVTLS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 DKDVTLSPVK 10 1 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 DKDVT(0.043)LS(0.957)PVK 83.85600000000002 0.021509 80989000.0 127320.0 95022.0 113300.0 113450.0 101630.0 89152.0 101590.0 114570.0 75764.0 86712.0 True False 120244.06410234241 102309.88185611345 106010.40135171289 97997.9142878338 88862.33081627231 101431.87875872113 106314.13629676616 114903.37973191548 90918.9170230334 84208.39925516742 1.4279343291870459 1.2149605355410582 1.2589053145456581 1.163754627265643 1.0552668332644894 1.2045339853969115 1.262512258125394 1.3645121003159846 1.079689411355889 1.0 16.361676519722735 -14.522878745280336 0.17262324969981738 0.14560087340310313 1.273138367828014 0.331033083882842 0.10451055673560126 184.6859436865011 1.7466327977002387 54.37018999872086 0.3836739001581251 3.0000000000000132e-15 14.522878745280336 1.1275374944249108 DKEADEEGGENGPADQGFQPQEEEEREDS(ph)DTEEQVPEALER ddPTM_A459_Selumetinib_30min_R2 1 DKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALER 41 2 Q9NU22 Q9NU22 MDN1 Midasin 1 DKEADEEGGENGPADQGFQPQEEEEREDS(0.733)DT(0.267)EEQVPEALER 97.55 1.8204e-16 10414000.0 19040.0 10707.0 17253.0 18684.0 19286.0 16131.0 16975.0 18815.0 11701.0 18509.0 True False 17981.833023158993 11528.192471568756 16142.960763646082 16139.206968302247 16863.120260972428 18352.89882736149 17764.37113532437 18869.748535009072 14041.526953256342 17974.597077842645 1.000402565091446 0.641360272035227 0.8980986162713807 0.8978897773567959 0.9381640204752996 1.021046466181163 0.9883042751051471 1.0498009192244917 0.7811872996344038 1.0 14.133671810836363 -5.909560216339931 1.819796992292221 0.9699890601265423 0.8194113230083401 0.19480130055144274 0.10721850332277129 0.47854135029854955 3.2220969266984225 0.03306074217789373 0.058597018387131966 1.2315152203144071e-06 5.909560216339931 -0.15057773711820222 DKEDPQEMPHS(ph)PLGSMPEIR ddPTM_A459_Selumetinib_30min_R1 2 DKEDPQEMPHSPLGSMPEIR 20 1 Q9HB58-7;G5E9C0;Q9HB58-2;Q9HB58-5;Q9HB58-3;Q9HB58;Q9HB58-6 Q9HB58-7 SP110 Sp110 nuclear body protein 1 DKEDPQEMPHS(0.982)PLGS(0.018)MPEIR;DKEDPQEMPHS(0.921)PLGS(0.079)MPEIR 113.23 0.00016947 14288900.0 2459.2 2745.3 2600.2 2330.6 2751.2 2302.0 2652.2 2541.4 1378.1999999999998 2094.6000000000004 True False 2516.4945752297845 2423.8789997446547 2247.1071218762268 1923.6044607802953 2502.3544457638122 2278.843970048767 2452.14241870153 2473.9938163693805 2338.7047402546377 2363.462313131764 1.0647491864997167 1.0255627882353808 0.9507691785017897 0.81389258889065 1.0587663834791619 0.9641972953776989 1.0375212691469822 1.0467667720460303 0.9895248708898089 1.0 11.206686144877416 DKEDPQEMPHS(ph)PLGSMPEIR ddPTM_A459_Selumetinib_30min_R2 4 DKEDPQEMPHSPLGSMPEIR 20 1 Q9HB58-7;G5E9C0;Q9HB58-2;Q9HB58-5;Q9HB58-3;Q9HB58;Q9HB58-6 Q9HB58-7 SP110 Sp110 nuclear body protein 1 DKEDPQEMPHS(0.883)PLGS(0.117)MPEIR;DKEDPQEMPHS(0.985)PLGS(0.015)MPEIR;DKEDPQEMPHS(0.972)PLGS(0.028)MPEIR;DKEDPQEMPHS(0.987)PLGS(0.013)MPEIR 79.589 0.0018986 56360600.0 289931.0 243027.0 286720.0 309658.0 338418.0 242707.0 277400.0 277906.0 222683.0 277861.0 True False 273817.7957057513 261666.38944503 268272.7473571327 267482.04621015495 295902.9053446938 276137.68617521675 290299.64965767215 278714.6604501849 267225.8222828797 269838.4309604212 1.0147472127345483 0.9697150569460958 0.9941976997208447 0.9912674234656668 1.0965928918705268 1.0233445443348264 1.0758276670392146 1.03289460829642 0.9903178777454248 1.0 18.04173630903727 -6.08509851456253 24.999595868219497 1.0398574131528797 0.9909265177298497 0.3158212732380966 0.03147182996452228 89.05378177508753 26159.95841185362 0.009068938154211602 0.011707953020372627 8.220561550875903e-07 6.08509851456253 -0.048930895423029974 DKEISPS(ph)VTK ddPTM_A459_Selumetinib_30min_R1 1 DKEISPSVTK 10 1 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 DKEIS(0.014)PS(0.986)VTK 148.13 0.0037894 9988000.0 3978.3 4502.5 3512.6 3822.4 3526.0 3774.6 3839.7 3789.9 2309.1 3700.7 True False 4070.986649575739 3975.3452068445386 3035.608213330679 3154.8895953345063 3207.0739225658613 3736.630951062587 3550.0683376397933 3689.3795406698346 3918.3740500086983 4175.7208928705795 0.9749182845353341 0.9520141093797355 0.7269662631220222 0.755531721653382 0.7680288038507223 0.8948469131263842 0.8501689717100119 0.883531163916846 0.9383706791080643 1.0 12.027809569383965 -8.327017648365075 1.1365762861229007 0.9994829527389651 0.8377650887327627 0.3021817896706914 0.07668235862433295 0.6355161529893546 1.709536688111371 0.08024236962279516 0.026185746542751607 4.70958187745046e-09 8.327017648365075 -0.16171786400620247 DKENGNNS(ph)PLPK ddPTM_A459_Selumetinib_30min_R1 2 DKENGNNSPLPK 12 1 Q6P1L5 Q6P1L5 FAM117B Protein FAM117B 1 DKENGNNS(1)PLPK;DKENGNNS(1)PLPK 107.93 0.025285 27326900.0 6779.700000000001 6731.0 8753.7 8259.7 6796.1 6739.7 7651.1 6980.7 3946.99 6666.4 True False 6937.653819000234 5942.931390842991 7564.9956206322295 6817.29844877156 6181.393954948908 6671.904737157985 7073.971367064048 6795.549159490732 6697.753753256173 7522.097376234884 0.9223031120175171 0.7900630759738543 1.0057029631832308 0.9063028710994826 0.8217646815472291 0.8869739918864951 0.9404253911167604 0.9034114848021524 0.890410402611495 1.0 12.87691926736334 -14.522878737946499 0.28598238339426324 1.7934932478016976 0.8895874172643148 0.23369748504401966 0.056305112314740655 363.45493020049184 3.445098593620047 171.62674428546984 0.06181645284255932 3.0000000506603628e-15 14.522878737946499 -0.9039058305373828 DKEPFTFSSPAS(ph)GR ddPTM_A459_Selumetinib_30min_R2 1 DKEPFTFSSPASGR 14 1 H0YEX2;Q6P1X5 H0YEX2 TAF2 Transcription initiation factor TFIID subunit 2 1 DKEPFTFS(0.077)S(0.346)PAS(0.577)GR 77.027 0.022553 6336900.0 31486.0 26763.0 30149.0 32564.0 38330.0 24257.0 29008.0 31739.0 24852.0 33010.0 True False 29736.134168444514 28815.63604339165 28209.246163749223 28128.72702396671 33514.64272545229 27598.181566877935 30356.929478261547 31831.355235325693 29823.094422897757 32056.915529719878 0.9276043461160892 0.8988898516039933 0.8799738121278857 0.8774620564442216 1.0454730959496388 0.8609119471051959 0.9469697560302619 0.9929637555370832 0.9303170292615598 1.0 14.96834799767903 -7.386086224016714 0.28378288334354546 1.0036535656247847 0.883819742407733 0.2240278574874005 0.05070249308119519 2.98770008931649 0.7313684054052637 0.09021238763316625 0.13134826020971324 4.110681003081531e-08 7.386086224016714 -0.11983382321705172 DKEVS(ph)DDEAEEK ddPTM_A459_Selumetinib_30min_R1 4 DKEVSDDEAEEK 12 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK 168.47 0.0018382 267892000.0 20723.84 25157.699999999997 15086.429999999998 12832.8 12530.880000000001 16220.09 20534.24 22763.17 14306.55 26640.98 True False 21206.665150426976 22212.224788502575 13037.775669828143 10591.792381490337 11397.464116506555 16056.930621263384 18985.325744588525 22159.416786403166 24277.170440930207 30060.609288120417 0.7054635834945497 0.738914656572865 0.43371628115936134 0.3523478942150412 0.37914947123213144 0.5341518685587283 0.6315682281294043 0.7371579389497037 0.8076073977157957 1.0 14.875586630588208 -8.125920827168706 1.0989380949504035 0.9784781693104208 0.5168682650069588 0.6229658322010734 0.12050934595058199 0.3588341113391894 0.8262181700864357 0.1291237635262695 0.04442489220494847 7.483059058760562e-09 8.125920827168706 -0.46160990430346194 DKEVS(ph)DDEAEEK ddPTM_A459_Selumetinib_30min_R2 6 DKEVSDDEAEEK 12 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK;DKEVS(1)DDEAEEK 151.38 0.002488 855382000.0 708153.0 470964.0 492733.0 509628.0 456726.0 462216.0 855868.0 770084.0 494738.0 378174.0 True False 668796.6912210666 507085.4244120589 461031.095227127 440215.78724266373 399347.9966977543 525882.0584209117 895667.5578702677 772324.8169457313 593699.4241347014 367255.13400594715 1.8210683236091574 1.3807442768215934 1.2553428190323441 1.198664760491912 1.087385742826096 1.4319256825212845 2.4388156214468704 2.102965337805801 1.616585771473755 1.0 18.486423133368532 -7.026808440643771 24.18694935875111 1.8892006244238735 1.329184002959181 0.20715337385835286 0.39221568614970265 595.9202456092214 537645.6564438592 0.14653963374264015 0.11390554193329881 9.401378967634526e-08 7.026808440643771 -0.5600166214646924 DKEVS(ph)DDEAEEKEDK ddPTM_A459_Selumetinib_30min_R1 2 DKEVSDDEAEEKEDK 15 2 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DKEVS(1)DDEAEEKEDK;DKEVS(1)DDEAEEKEDK 100.27 0.0087041 51275400.0 6576.709999999999 7483.349999999999 4908.450000000001 4763.56 4241.22 5039.67 6152.379999999999 7166.1 5325.7699999999995 9393.4 True False 6729.934546950015 6607.195903084969 4241.909450185896 3931.693669095762 3857.6023998482096 4988.975495454243 5688.301023290443 6976.031749226652 9037.442711149284 10599.134389464298 0.6349513365581696 0.6233712735685872 0.40021281873757725 0.37094478894464494 0.363954475724237 0.47069650333081553 0.5366759977064449 0.6581699498178771 0.8526585642816871 1.0 13.371658827071903 -8.191146798673994 1.375956667170685 0.9953111027084444 0.47104988259838504 0.8046452420445089 0.08806968606164954 0.19359950920939967 0.6874332961997626 0.09371372459616423 0.02972153268377935 6.439515625099843e-09 8.191146798673994 -0.5242612201100594 DKEVS(ph)DDEAEEKEDK ddPTM_A459_Selumetinib_30min_R2 2 DKEVSDDEAEEKEDK 15 2 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DKEVS(1)DDEAEEKEDK;DKEVS(1)DDEAEEKEDK 88.385 0.019986 150732000.0 121233.0 81910.0 72419.0 73030.0 59959.0 66444.0 154235.0 115747.0 63588.0 57158.0 True False 114495.35519415096 88192.23361783828 67759.64038384537 63083.188016223095 52426.41437973899 75596.05788142137 161407.23311085452 116083.80460705252 76307.37679716815 55507.70002568101 2.0626931964606516 1.588828821533509 1.2207250589106722 1.1364763444898136 0.9444890412588444 1.3619021837771397 2.907835003723418 2.091309936339383 1.3747169629053992 1.0 15.760400295486495 -7.077987719107596 24.999999999698865 1.9630461704920588 1.355563219423986 0.12892593534941188 0.5451857385177667 183.64430318433713 58868.02620496512 0.21093981163421097 0.16339331364931226 8.356266475801831e-08 7.077987719107596 -0.6074829510680728 DKEVS(ph)DDEAEEKEDKEEEK ddPTM_A459_Selumetinib_30min_R1 2 DKEVSDDEAEEKEDKEEEK 19 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DKEVS(1)DDEAEEKEDKEEEK;DKEVS(1)DDEAEEKEDKEEEK 96.881 0.0066506 50655000.0 4782.7 6409.5 4267.4 3938.5 2998.3 4498.4 4135.4 5364.2 4310.3 8066.6 True False 4894.127604485807 5659.0727603042915 3687.9105191503004 3250.7149098014215 2727.1042943928605 4453.150180220408 3823.4634485703596 5221.923990622742 7314.264288143642 9102.026685337865 0.5376964684546118 0.6217376586491767 0.40517465468333835 0.35714187863653307 0.29961506252073034 0.4892482008862742 0.42006726422033486 0.5737100286724666 0.8035863375269964 1.0 13.151972100670251 -8.336070581736386 1.7022552854994348 0.9962389365917583 0.44323886413008523 0.8196661544171625 0.08641479755993789 0.1526725528126963 0.8772154345218353 0.0911931609169062 0.026851627731341685 4.612426071107416e-09 8.336070581736386 -0.553000072461673 DKFS(ph)PFPVQDRPESSLVFK ddPTM_A459_Selumetinib_30min_R2 2 DKFSPFPVQDRPESSLVFK 19 2 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 DKFS(0.999)PFPVQDRPESSLVFK;DKFS(1)PFPVQDRPESSLVFK 60.272 0.032897 34076700.0 62260.0 56659.0 61685.0 65576.0 59468.0 51589.0 53760.0 60986.0 49377.0 67538.0 True False 58799.83844652725 61004.563112600525 57716.25425754992 56644.43567509027 51997.0981893347 58694.9164716851 56259.946523419094 61163.45916322419 59253.77970865212 65588.00245520206 0.8965029616001605 0.9301177170972371 0.8799818884097178 0.8636402017850684 0.7927836836447302 0.8949032486814174 0.857778014536207 0.9325403560658838 0.9034240637092683 1.0 16.001144316627965 -8.6976392835881 0.9544215988032194 0.9985610878964681 0.8743116590629162 0.504026272396112 0.036446841893474746 0.6974755234705072 1.3033415404412083 0.03736599910489852 0.012437377324249538 2.0061375938059027e-09 8.6976392835881 -0.12424942883355194 DKGEYTLVVK ddPTM_A459_Selumetinib_30min_R1 1 DKGEYTLVVK 10 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 108.9 0.029296 7682100.0 1790.0 1834.8 2081.5 2191.8 2054.0 1691.2 1642.5 1952.4 1099.6 1634.0 False True 1831.7035172663122 1619.9807630246223 1798.8437328610735 1809.043275181606 1868.216062663153 1674.1880634867398 1518.604902615663 1900.6160097110176 1865.9408883935569 1843.7398165078303 0.9934718016426441 0.8786384871228615 0.9756494472567214 0.9811814329681604 1.0132753254749807 0.9080392192526204 0.8236546659235275 1.030848275170905 1.0120413258351044 1.0 10.848419365636552 DKKS(ph)PLIESTANMDNNQSQK ddPTM_A459_Selumetinib_30min_R1 2 DKKSPLIESTANMDNNQSQK 20 2 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 DKKS(0.601)PLIES(0.256)T(0.143)ANMDNNQSQK;DKKS(0.999)PLIES(0.001)TANMDNNQSQK 110.44 0.0011461 42016000.0 4185.4 4578.3 6300.400000000001 6680.5 4688.3 4912.200000000001 4481.9 4280.8 2854.4 3289.1 True False 4282.91167662929 4042.270507606075 5444.840285619944 5513.876083516163 4264.2440927865955 4862.787727920748 4143.826674601611 4167.259278001905 4843.708322872474 3711.2880235470643 1.1540229832487903 1.0891826454748381 1.4671025937825317 1.4857041675375748 1.148993035768494 1.310269560612851 1.116546775219334 1.1228606487995092 1.3051286486364102 1.0 11.857704253905146 -7.261593445293005 24.92060802966605 1.1463724029695268 1.2798548832501648 0.1914689466197803 0.13990921321955235 26.467600612938018 4280599.521737232 0.05919734277601448 0.04284038729391139 5.4752827896012735e-08 7.261593445293005 0.13348248028063803 DKKS(ph)PLIESTANMDNNQSQK ddPTM_A459_Selumetinib_30min_R2 2 DKKSPLIESTANMDNNQSQK 20 2 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 DKKS(0.999)PLIES(0.001)T(0.001)ANMDNNQSQK;DKKS(0.948)PLIES(0.026)T(0.026)ANMDNNQSQK 70.944 0.0040527 84624000.0 189832.0 185495.0 182566.0 184366.0 179149.0 146439.0 156364.0 154280.0 105874.0 182513.0 True False 179281.89739770564 199721.87003956677 170819.9023228311 159255.03275091018 156642.70100761938 166609.6430091123 163635.23582938794 154728.9292575712 127051.75836672634 177243.37546427627 1.0115012588091916 1.1268227628615721 0.9637590227300775 0.8985104934599281 0.8837718227680166 0.9400049089151588 0.9232234231646583 0.8729743994790773 0.7168209138080529 1.0 17.435372181656547 -5.51719538547138 3.294686389690488 0.8889479775050879 1.0686445818828714 0.4840027160469925 0.07299211506467478 0.1953570351111016 4.387822783929476 0.02011290733491449 0.042333535532225366 3.03951726451753e-06 5.51719538547138 0.17969660437778345 DKLCS(ph)PLSEPGDPSK ddPTM_A459_Selumetinib_30min_R1 1 DKLCSPLSEPGDPSK 15 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 DKLCS(0.944)PLS(0.056)EPGDPSK 166.92 2.6177e-05 0.0 681.93 749.17 707.19 896.52 727.86 576.65 794.49 490.01 462.32 398.56 True False 697.8176421952049 661.4568281203162 611.15748231661 739.9596117646747 662.0251915141199 570.8494245563082 734.5609796524312 477.0133430232002 784.5232734831844 449.7190583031583 1.5516746050926797 1.4708223187517755 1.3589761675268497 1.6453819292351706 1.4720861375366592 1.2693467488573615 1.6333774744259544 1.0606918568739923 1.7444741533598351 1.0 8.81288021395698 -12.47905703580934 0.3491964222447358 3.384043801543313e-20 1.4749326934271674 0.3372327046202195 0.19199122744274352 96.45205064115122 3.0014428147041237 71.80648767277188 0.1383120944972116 3.318508727804862e-13 12.47905703580934 1.4749326934271674 DKLCS(ph)PLSEPGDPSK ddPTM_A459_Selumetinib_30min_R2 3 DKLCSPLSEPGDPSK 15 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 DKLCS(1)PLSEPGDPSK;DKLCS(0.999)PLS(0.001)EPGDPSK;DKLCS(1)PLSEPGDPSK 112.82 0.0016029 20525800.0 185571.0 185181.0 192710.0 198445.0 189890.0 162594.0 160500.0 164970.0 122002.0 208115.0 True False 175257.7067195714 199383.7872492365 180311.2484067837 171416.4486632809 166034.32056186127 184989.84761862332 167963.56802471646 165450.03538774647 146405.80902069775 202106.1792022916 0.8671565976424348 0.9865298925356943 0.892160987449607 0.8481504590302862 0.8215202583968233 0.9153102015424465 0.8310659708063591 0.8186292771491398 0.7244004591970324 1.0 17.624753905843832 -5.608636415470343 3.7888105091783357 0.8444045999323015 0.929554075872481 0.14566529778864057 0.07231489846037864 0.3539066094758887 9.793345720262193 0.019393812658893034 0.0360999878417166 2.4624282477713196e-06 5.608636415470343 0.08514947594017941 DKLESEMEDAYHEHQANLLR ddPTM_A459_Selumetinib_30min_R1 1 DKLESEMEDAYHEHQANLLR 20 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 125.96 9.1066e-05 11469000.0 4614.1 6097.5 5970.2 6410.6 5233.6 4821.4 5042.8 4752.8 2682.0 4021.6 False True 4721.599552524299 5383.601865349156 5159.479631961175 5291.109051865682 4760.22180406713 4772.901093480942 4662.417536018425 4626.740304729831 4551.158114470281 4537.811533701281 1.0405014658405414 1.1863872761939063 1.1369973375145503 1.1660045844940525 1.0490126724554465 1.0518068143715764 1.0274594926192337 1.0195972817222787 1.0029411932756302 1.0 12.147780976298874 -6.415583122211564 3.6270848268719953 1.023697855263869 1.1364338644860055 0.6571485730881028 0.03821842302073817 0.14814548617109333 3.5537094557711764 0.01217241717994579 0.013760317776427515 3.840757415962094e-07 6.415583122211564 0.11273600922213656 DKLNNLVLFDK ddPTM_A459_Selumetinib_30min_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 0 103.44 0.015515 0.0 4007.0 4732.9 5125.0 5431.8 4508.3 4347.2 3753.8 3684.1 2725.3 3422.5 False True 4100.355303735262 4178.769867734484 4429.053149609898 4483.23809751412 4100.5250610050125 4303.47111494179 3470.6478437982814 3586.385700356669 4624.635051963406 3861.8112129731035 1.0617700031427766 1.082075129332219 1.1468849473353957 1.1609159149089003 1.0618139610838537 1.1143660002034808 0.8987098675717822 0.9286797056025968 1.1975300699391322 1.0 11.91506192363613 -7.2132251746633 24.935628617705873 1.000286452250504 1.1061440307680106 0.26635149562125027 0.07974419607272669 494.8933725170958 255951.25157860926 0.030649764626685748 0.023741171733027307 6.120329802461041e-08 7.2132251746633 0.10585757851750666 DKMEGS(ph)DFESSGGR ddPTM_A459_Selumetinib_30min_R1 1 DKMEGSDFESSGGR 14 1 E9PEN0;A0A1B0GW41;Q8WYH8-2;Q8WYH8 E9PEN0 ING5 Inhibitor of growth protein 5 1 DKMEGS(0.781)DFES(0.218)SGGR 207.85 3.0632e-05 20791000.0 2341.5 3168.8 2250.7 2473.0 2180.1 2426.8 2674.0 1981.0 1477.6 1878.5 True False 2396.052394234118 2797.7954228648464 1945.0673022101464 2041.1369739593536 1982.910339927916 2402.388595358101 2472.29802715025 1928.4574448051242 2507.379280365878 2119.6237731395104 1.1304140029931686 1.3199490675276078 0.9176474272739368 0.9629713536077655 0.9355010851717807 1.1334033076066936 1.166385307845633 0.9098111982150315 1.1829360059743235 1.0 11.04959249813264 -5.2590256074378345 24.999981054220193 1.0262156895617107 1.225181534847169 0.3617292351718595 0.10578897857110706 219.02559753448455 2268461.4703517607 0.027291425707137298 0.06549113273051538 5.5077521992087885e-06 5.2590256074378345 0.19896584528545835 DKNNKEPIIEDILNLES(ph)SPTASGSSVSPGLYSK ddPTM_A459_Selumetinib_30min_R1 1 DKNNKEPIIEDILNLESSPTASGSSVSPGLYSK 33 2 Q9BQL6-4;Q9BQL6-2;Q9BQL6 Q9BQL6-4 FERMT1 Fermitin family homolog 1 1 DKNNKEPIIEDILNLES(0.427)S(0.427)PT(0.131)AS(0.013)GS(0.001)SVSPGLYSK 88.295 7.8227e-09 22868000.0 1945.0 2320.9 3041.8 3352.5 2895.9 2292.1 2225.1 2467.6 1233.3 2091.1 True False 1990.3147156888153 2049.1679490428623 2628.740267411392 2767.0488092190594 2633.9663563126724 2269.043555060287 2057.258915561714 2402.1512321055643 2092.820023331915 2359.5130540388764 0.8435277407268043 0.8684706980261103 1.1141028708918004 1.1727202799249563 1.116317772348834 0.9616575552215195 0.8718997812028284 1.0180707531978694 0.8869711569298369 1.0 11.204273437889356 -6.978670618333082 24.64487494612756 0.9416037761376957 1.0289343912599742 0.11195327234792884 0.1062020797509948 474.9234257627012 548744.7360360436 0.04182647258204101 0.03688388293879164 1.0503387343313722e-07 6.978670618333082 0.08733061512227847 DKPTYDEIFYTLS(ph)PVNGK ddPTM_A459_Selumetinib_30min_R1 2 DKPTYDEIFYTLSPVNGK 18 1 A0A024R571;Q9H4M9 A0A024R571 EHD1 EH domain-containing protein 1 1 DKPTYDEIFYT(0.05)LS(0.95)PVNGK;DKPTYDEIFYTLS(1)PVNGK 149.82 8.7989e-05 469510000.0 15162.199999999999 17949.9 20123.7 21886.3 16101.2 15482.8 16457.4 15387.1 8549.7 12604.2 True False 15515.449759494566 15848.317363317881 17391.012071571655 18064.26856173337 14644.849302897741 15327.057089257632 15216.00506807125 14978.984123655195 14508.216454618405 14222.071845304778 1.0909415961512514 1.1143465970149762 1.222818465603031 1.2701573130990083 1.029726854300243 1.0776950964649816 1.0698866686638633 1.05322095729676 1.0201197555761254 1.0 13.795844028980556 -6.286881461110234 24.91456243813716 1.0476375245179093 1.1737112224132675 0.6105146237010284 0.05183180243451931 561.716153735385 550067.8754827483 0.017426184512130988 0.01976687794823639 5.165573422308137e-07 6.286881461110234 0.12607369789535827 DKPTYDEIFYTLS(ph)PVNGK ddPTM_A459_Selumetinib_30min_R2 3 DKPTYDEIFYTLSPVNGK 18 1 A0A024R571;Q9H4M9 A0A024R571 EHD1 EH domain-containing protein 1 1 DKPTYDEIFYT(0.003)LS(0.997)PVNGK;DKPTYDEIFYTLS(1)PVNGK;DKPTYDEIFY(0.002)T(0.039)LS(0.958)PVNGK 136.53 0.00019279 35499900.0 424031.0 378835.0 408359.0 459363.0 450720.0 377546.0 433573.0 411165.0 325704.0 436192.0 True False 400465.05455058464 407890.4263534842 382085.62652766146 396796.96695462574 394096.52411207557 429549.53447864467 453735.00360860117 412361.4220779702 390853.9009301254 423598.0035970781 0.9453893813236729 0.962918670271792 0.9020005365537493 0.93673002135311 0.9303550082047506 1.0140499502618705 1.0711452833951245 0.9734734785723966 0.9227000543229695 1.0 18.692336264410635 -6.756022205921868 24.96266262304631 0.9992953190255652 0.9352127727960166 0.39786701535825253 0.03730194400850722 142.81550232027303 658102.2636934282 0.013423623620963372 0.013051914036774867 1.7537908264271728e-07 6.756022205921868 -0.06408254622954868 DKPVYDELFYT(ph)LSPINGK ddPTM_A459_Selumetinib_30min_R2 1 DKPVYDELFYTLSPINGK 18 1 Q9H223 Q9H223 EHD4 EH domain-containing protein 4 1 DKPVYDELFY(0.005)T(0.63)LS(0.365)PINGK 96.131 0.048086 0.0 39829.0 31523.0 31173.0 44576.0 39675.0 35400.0 35129.0 51061.0 28153.0 35329.0 True False 37615.46362811972 33940.71273757932 29167.36311859612 38504.671902110946 34690.67180099977 40276.02867079517 36762.56810679295 51209.57905639639 33784.38666054404 34308.95997423431 1.0963743481693575 0.9892667327446958 0.850138364453499 1.122292017333885 1.0111257183852882 1.1739215849458002 1.0715150833601854 1.4926007402979942 0.9847103114147377 1.0 15.066297772925164 -6.665989585733209 1.5316937580810748 1.1781711884863866 0.995672688298062 0.13330564589159333 0.15082641963267387 0.6057271220938331 2.9469102200466195 0.0622499825544597 0.061090993165646396 2.1577961519131896e-07 6.665989585733209 -0.18249850018832459 DKPVYDELFYTLS(ph)PINGK ddPTM_A459_Selumetinib_30min_R1 1 DKPVYDELFYTLSPINGK 18 1 Q9H223 Q9H223 EHD4 EH domain-containing protein 4 1 DKPVYDELFYT(0.003)LS(0.997)PINGK 128.75 0.00036526 40785000.0 10051.0 11433.0 12831.0 13043.0 11643.0 10194.0 11491.0 11096.0 6252.2 9888.9 True False 10285.1687441585 10094.419044942495 11088.620675637974 10765.284897433019 10589.89270573861 10091.457615411435 10624.224618542827 10801.6980351124 10609.526757379232 11158.236641043019 0.9217557464525229 0.9046607783717802 0.99376102446609 0.9647837058622133 0.9490650759983091 0.9043953753671363 0.9521418984308012 0.9680470474502062 0.9508246776515311 1.0 13.445821432681795 -14.522878734719024 0.15949330311192647 1.20265873862874 0.9313027658522519 0.30527018418800034 0.02621194217131017 188.52505323813668 1.7246362703301266 12.050306963333961 0.12139064900567773 3.000000072954972e-15 14.522878734719024 -0.27135597277648804 DKRPLS(ph)GPDVGTPQPAGLASGAK ddPTM_A459_Selumetinib_30min_R1 2 DKRPLSGPDVGTPQPAGLASGAK 23 2 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 DKRPLS(0.995)GPDVGT(0.005)PQPAGLASGAK;DKRPLS(0.975)GPDVGT(0.025)PQPAGLASGAK 87.648 0.00025819 578650000.0 5484.3 5832.3 6832.8 7606.2 5987.8 5508.0 5519.5 5235.9 3431.7 4544.799999999999 True False 5612.073519409854 5149.451604637291 5904.943289883806 6277.919956057276 5446.204547231954 5452.5945208638595 5103.159671225056 5097.026923399876 5823.344258548718 5128.16935010085 1.0943619713532837 1.0041500685885154 1.1514719750367994 1.2242029323649022 1.0620172961185164 1.0632633496701174 0.9951230785942545 0.9939271844249133 1.1355600529132674 1.0 12.324228190245197 -6.508415972686819 24.192756852916684 1.037663971753477 1.1165251951089517 0.26207899463845474 0.06427700199659825 676.7238413808963 1131999.78340963 0.021552374719290005 0.02354219652904664 3.10158742573813e-07 6.508415972686819 0.07886122335547463 DKRPLS(ph)GPDVGTPQPAGLASGAK ddPTM_A459_Selumetinib_30min_R2 2 DKRPLSGPDVGTPQPAGLASGAK 23 2 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 DKRPLS(0.944)GPDVGT(0.056)PQPAGLASGAK;DKRPLS(0.976)GPDVGT(0.024)PQPAGLASGAK 79.163 0.00073892 352670000.0 141562.0 116492.0 128305.0 135115.0 121950.0 120806.0 106408.0 109744.0 81638.0 115010.0 True False 133694.5507575858 125426.56181918275 120049.99598792143 116712.1039136246 106629.55075316745 137445.92993231886 111356.18284345196 110063.33687090271 97967.88115630657 111689.3624681333 1.1970213438699762 1.1229946975028073 1.0748561307454283 1.044970634037994 0.9546974608579264 1.2306089576931223 0.9970169081699575 0.9854415356906122 0.8771460324545975 1.0 16.769132261464172 -1.5228787452803831 0.22923166149161164 0.95728948738762 2.227687437969591 0.3956182418365555 0.08102306429208525 56.71428638219098 0.7410718546590555 0.12357732044027162 27.003840241103273 0.029999999999996852 1.5228787452803831 1.270397950581971 DKRPLSGPDVGT(ph)PQPAGLASGAK ddPTM_A459_Selumetinib_30min_R2 1 DKRPLSGPDVGTPQPAGLASGAK 23 2 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 DKRPLSGPDVGT(1)PQPAGLASGAK 65.184 0.0057627 4421500.0 27673.0 31609.0 35074.0 30880.0 34399.0 28768.0 28083.0 28549.0 21544.0 30611.0 True False 26135.04544379616 34033.30866104574 32817.37702568378 26674.09072902876 30077.490089038212 32730.530870097056 29388.915145408802 28632.07286345861 25853.40198965514 29727.18089307044 0.8791632660293185 1.1448548983997027 1.1039518729922246 0.8972963438738528 1.0117841377972518 1.1010304336569874 0.9886209947428789 0.9631613897883231 0.8696889921264516 1.0 14.859495034707944 -7.727486890658679 2.9913298737154066 0.9327159061710873 1.0267122917544658 0.1407913685998966 0.08575448422517302 0.46240329263849983 8.382242495437717 0.050524168901607845 0.024089364497298163 1.8728936161583944e-08 7.727486890658679 0.09399638558337842 DKS(ph)DSDTEGLLFSR ddPTM_A459_Selumetinib_30min_R1 1 DKSDSDTEGLLFSR 14 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 DKS(0.712)DS(0.254)DT(0.033)EGLLFS(0.001)R 75.877 0.023858 26130000.0 2547.4 2913.1 2606.0 3108.1 2352.2 2204.0 2846.9 3002.5 1458.7 2939.4 True False 2606.7494636224615 2572.0328977365525 2252.1195137333452 2565.3286812628667 2139.443925314639 2181.8297610718873 2632.1560409476606 2922.8639465054957 2475.3073607672636 3316.7006221806123 0.7859465657496144 0.7754793666139009 0.6790240574238675 0.7734580155070657 0.6450518660041227 0.657831384141452 0.7936067618961375 0.881256489343261 0.7463161866987673 1.0 11.695533079607515 -8.8668403829967 0.637230169557871 1.0007552629845906 0.7241197966940403 0.5874371974314632 0.0651933349525172 0.9592447825535091 0.7561598370557042 0.07701046148884118 0.028014844496559065 1.3588127616327415e-09 8.8668403829967 -0.27663546629055036 DKS(ph)DSDTEGLLFSR ddPTM_A459_Selumetinib_30min_R2 2 DKSDSDTEGLLFSR 14 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 DKS(0.963)DS(0.028)DT(0.008)EGLLFSR;DKS(0.92)DS(0.062)DT(0.017)EGLLFSR 83.087 0.015679 32817800.0 72468.0 62883.0 59259.0 61785.0 53673.0 45955.0 66979.0 73043.0 44121.0 54061.0 True False 68440.5186723889 67705.92389928632 55446.34045632082 53369.776414930115 46930.11789729198 52284.88411204499 70093.65621637063 73255.54303708044 52946.43284374181 52500.11846265332 1.3036259855503947 1.2896337357305176 1.0561183875377982 1.016564875999193 0.8939049905320949 0.9959003073343264 1.3351142486703664 1.3953405284064602 1.008501207124056 1.0 15.68003305766706 -5.251582326028431 22.067877785006104 1.0978985253728295 1.296630071610178 0.23652108617403544 0.14926308597375346 239.1015126635768 535280.1706488598 0.04294835401325883 0.10993917478768053 5.602961960449206e-06 5.251582326028431 0.19873154623734846 DKS(ph)FDDEESVDGNRPSSAASAFK ddPTM_A459_Selumetinib_30min_R2 2 DKSFDDEESVDGNRPSSAASAFK 23 2 E7ERI8;E7EW49;O75122-3 E7ERI8 CLASP2 CLIP-associating protein 2 1 DKS(1)FDDEESVDGNRPSSAASAFK;DKS(0.78)FDDEES(0.005)VDGNRPS(0.087)S(0.087)AAS(0.041)AFK 98.747 6.521600000000001e-05 20349900.0 30087.0 34883.0 34114.0 27759.0 26341.0 22107.5 27507.0 27996.2 17817.6 28173.0 True False 28414.88498780379 37558.4139334765 31919.142380514826 23978.176313054068 23031.808088472204 25152.607453096163 28786.13000408647 28077.66430697961 21381.617865339722 27359.57228775518 1.0385719736021208 1.372770507464615 1.1666535589374065 0.876409033769345 0.8418190111392978 0.919334819585365 1.0521410825186674 1.026246463638827 0.7815040981071586 1.0 14.739758056295273 -5.6811907628178195 5.437249129657409 0.9308135900418529 1.2188191390615413 0.5518722982101223 0.10909766271769779 0.14414606369299884 7.189709915185991 0.029802346055698377 0.05206056480484776 2.0835754764965115e-06 5.6811907628178195 0.28800554901968833 DKS(ph)PSSLLEDAK ddPTM_A459_Selumetinib_30min_R1 2 DKSPSSLLEDAK 12 1 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 DKS(0.981)PS(0.014)S(0.004)LLEDAK;DKS(0.634)PS(0.287)S(0.079)LLEDAK 143.93 0.003725800000000001 73994500.0 7253.6 8731.5 7961.5 9000.5 6738.6 7628.8 7402.599999999999 8029.2 4894.7 7866.700000000001 True False 7422.594766951361 7709.211920835775 6880.372029389116 7428.731635309814 6129.094819796458 7552.06119839619 6844.215922132552 7816.239533482742 8305.948405256408 8876.467573146972 0.8362104300821357 0.8684999812490308 0.7751250114632953 0.8369017938828686 0.6904880538670758 0.8507957851660082 0.7710517574398206 0.8805574367362503 0.9357267783395621 1.0 13.115769949007907 -8.225847293339768 1.7394169157850339 0.9940892071154588 0.8038576125686853 0.6389510445231725 0.04972096531121275 0.21940747754893533 1.219843682405973 0.04560150367174807 0.013723020336947485 5.945011604140629e-09 8.225847293339768 -0.19023159454677352 DKS(ph)PVREPIDNLTPEER ddPTM_A459_Selumetinib_30min_R1 2 DKSPVREPIDNLTPEER 17 2 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 DKS(1)PVREPIDNLTPEER;DKS(1)PVREPIDNLTPEER 167.35 4.3649e-05 49840000.0 3408.1000000000004 3896.6 4097.4 4137.1 3099.8 2893.4 3379.0 3184.3999999999996 1959.04 2613.48 True False 3487.5020989918016 3440.384260519808 3540.995585407139 3414.633147985139 2819.4236373141416 2864.2950229970056 3124.119309551493 3099.9393676110253 3324.3477973795143 2948.9456154509708 1.1826267940375264 1.1666489346205469 1.2007666627875837 1.1579166228411277 0.9560785463596887 0.9712946240817601 1.0594021446793396 1.0512026235305678 1.127300476469158 1.0 11.525983501079144 -6.13483986546919 6.052711370073179 1.029281280941192 1.181069381961968 0.7170768615748637 0.046133015745476756 0.13861053096476214 6.254607004598833 0.014767009286839598 0.019209968366412908 7.330947925026986e-07 6.13483986546919 0.151788101020776 DKS(ph)PVREPIDNLTPEER ddPTM_A459_Selumetinib_30min_R2 4 DKSPVREPIDNLTPEER 17 2 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 DKS(1)PVREPIDNLTPEER;DKS(0.999)PVREPIDNLT(0.001)PEER;DKS(1)PVREPIDNLTPEER;DKS(0.999)PVREPIDNLT(0.001)PEER 67.994 0.014711000000000004 2494973000.0 288263.0 234043.0 257430.0 268900.0 284417.0 246237.0 253937.0 252898.0 209020.0 273583.0 True False 272242.49646821857 251993.3455331429 240867.2340685912 232275.35612162616 248685.9937397591 280153.9116330674 265745.5736666194 253633.89131048234 250829.84050676343 265683.947936 1.0246855279860507 0.9484703441468169 0.906593100335189 0.8742543835489016 0.9360218999744181 1.0544630709136897 1.0002319512755593 0.9546451461628371 0.9440910617873882 1.0 18.0193515403055 -6.572452632693845 24.999199441287658 0.9892031892141763 0.9329591134290304 0.24913904530848519 0.04530139581012749 165.00483707379328 83207.70569317418 0.01615399591765271 0.01615399854355291 2.676377482421391e-07 6.572452632693845 -0.0562440757851459 DKSDS(ph)DTEGLLFSR ddPTM_A459_Selumetinib_30min_R2 2 DKSDSDTEGLLFSR 14 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 DKS(0.227)DS(0.761)DT(0.012)EGLLFSR;DKS(0.207)DS(0.747)DT(0.046)EGLLFSR 110.26 0.016033000000000002 38702500.0 39699.0 32150.0 32842.0 37835.0 26753.0 25458.8 32688.2 32634.5 26461.0 26943.5 True False 37492.68850768848 34615.80162145657 30728.981475665925 32681.807730984558 23392.04896514547 28965.518608023744 34208.26607043951 32729.4609920677 31753.93938211402 26165.571147379807 1.432901590280897 1.3229522652679784 1.1744051487575915 1.2490385761847693 0.8940010838436419 1.1070088416902117 1.3073770061336913 1.25085979616941 1.2135771546226624 1.0 14.675382130284966 -5.035695887338471 1.6251523837254513 1.1515758888813294 1.4690026123620787 0.39533900286787504 0.11761423925555578 0.720933164198072 2.6360276994341545 0.03601835390341888 0.3114417191836448 9.210943379431103e-06 5.035695887338471 0.3174267234807493 DKSPSS(ph)LLEDAK ddPTM_A459_Selumetinib_30min_R1 1 DKSPSSLLEDAK 12 1 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 DKS(0.353)PS(0.219)S(0.428)LLEDAK 135.72 0.006964399999999999 10299000.0 2160.0 2544.1 2661.8 2389.2 1930.8 1916.5 2120.8 2320.6 1051.3 1765.0 True False 2210.323797371642 2246.235589279996 2300.342180220806 1971.9710708385317 1756.1594809104272 1897.2217500427723 1960.8263485341256 2259.050149628861 1783.9793160859817 1991.554942555888 1.109848264861322 1.1278803016085814 1.1550483147949873 0.9901665420828295 0.8818031797087341 0.9526333969013921 0.9845705517005088 1.134314751432205 0.8957720813850552 1.0 10.959679565649411 -5.789505400965079 8.22467222164997 0.9776842253734065 1.1306410283231323 0.5375802112265671 0.06541182138300963 0.16778300509919822 42.003302444214704 0.01912538890998558 0.02897729660039942 1.6236581582490436e-06 5.789505400965079 0.1529568029497258 DKTESVTSGPMSPEGSPS(ph)KSPSK ddPTM_A459_Selumetinib_30min_R2 2 DKTESVTSGPMSPEGSPSKSPSK 23 2 P35612 P35612 ADD2 Beta-adducin 1 DKTESVTSGPMSPEGS(0.103)PS(0.299)KS(0.299)PS(0.299)K;DKTESVTSGPMSPEGS(0.187)PS(0.351)KS(0.351)PS(0.11)K 104.35 9.1713e-06 49129000.0 179363.0 164926.0 161369.0 192076.0 149424.0 150947.0 159249.0 158050.0 147107.0 150046.0 True False 169394.7225069784 177575.29387932646 150986.69422528314 165914.9174504188 130652.02125249109 171738.57908956258 166654.39404590704 158509.89933341416 176532.51051300552 145713.78211367334 1.16251681927267 1.218658189386626 1.0361867768108326 1.1386357216435867 0.8966346172427783 1.178602165137591 1.1437105785635133 1.087816794225809 1.2115018082180453 1.0 17.152777813381448 -9.794817300188898 0.008958365812858778 1.872023360197347e-07 2.1513227969238256 0.07082401947826844 0.09396733750106681 17322.01458563031 40.505264892911015 5049.789728543984 4678.203763139321 1.603919988831149e-10 9.794817300188898 2.1513226097214897 DKTESVTSGPMSPEGSPSKS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 DKTESVTSGPMSPEGSPSKSPSK 23 2 P35612 P35612 ADD2 Beta-adducin 1 DKTESVTSGPMSPEGS(0.096)PS(0.096)KS(0.788)PS(0.02)K 184.66 1.7033000000000002e-17 16573000.0 1756.1 2277.5 1300.1 1613.6 1417.2 1555.0 1771.2 1770.9 861.37 1797.9 True False 1797.0137132242312 2010.8492412189748 1123.5535609381134 1331.8150510233777 1289.0145102269823 1539.3581118270345 1637.5969579986995 1723.9299793061048 1461.681978024335 2028.677978029026 0.8858053040878032 0.9912116476823134 0.5538353415901465 0.6564940643350949 0.6353963143422753 0.7587986504011873 0.8072237071305504 0.849780003517857 0.7205096096347635 1.0 10.986324161895093 -11.146081936958414 8.884798675601267 1.000107890815866 0.7597030487401588 0.2534094786660429 0.1224307134974143 0.0002822314711997973 1.1969095100454401e-05 0.12786654815717824 0.030998426110111096 7.143615370419883e-12 11.146081936958414 -0.24040484207570723 DKTESVTSGPMSPEGSPSKSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 DKTESVTSGPMSPEGSPSKSPSK 23 2 P35612 P35612 ADD2 Beta-adducin 1 DKTESVTSGPMSPEGS(0.313)PS(0.025)KS(0.316)PS(0.346)K 129.82 9.2031e-06 20701000.0 2842.6 4155.8 2550.5 2990.4 2360.7 3011.8 2983.4 3267.6 1834.2 2979.3 True False 2908.8270492632532 3669.237004020993 2204.156108893667 2468.1827767602304 2147.1751018154378 2981.5040264956037 2758.35973605088 3180.932633339334 3112.503435332361 3361.722175839523 0.8652788354043063 1.0914753843704155 0.6556627804447352 0.7342018904771186 0.6387128351197623 0.8868978072975446 0.820519838276652 0.9462211530151089 0.9258657534824618 1.0 11.714984784935012 -7.792404535960246 1.6264086944456235 0.9715614883041948 0.8055951329139798 0.22427340564564546 0.12257559789006722 0.6733867262969524 3.350912330594264 0.10439733329894473 0.040047408525514666 1.612855516718717e-08 7.792404535960246 -0.16596635539021498 DLADELALVDVIEDK ddPTM_A459_Selumetinib_30min_R1 4 DLADELALVDVIEDK 15 0 P00338;P00338-3;P00338-5;P00338-4;P00338-2;F5GYU2;F5GXY2;F5GXH2;F5H5J4;F5H6W8;F5GZQ4 P00338 LDHA L-lactate dehydrogenase A chain 0 ;;; 309.35 2.492499999999999e-93 50080800.0 23484.1 30598.8 19338.8 20213.800000000003 19401.0 19389.4 19903.6 17766.5 16699.5 23205.899999999998 False True 24031.233837895987 27016.27827100382 16712.697180424566 16683.839290020063 17646.18297552476 19194.360240166636 18402.2554275197 17295.27470627473 28337.83181677721 26184.603309607737 0.9177619975276987 1.0317619843830486 0.6382642877118666 0.6371621938568142 0.6739144667144897 0.7330399476826819 0.7027891623917589 0.660513145903902 1.0822326189825988 1.0 14.676431128022152 -8.266844750747024 24.82713406881076 1.0411163558411964 0.7467517851821146 0.4715894997314256 0.12349046565128402 414.1704781968235 1902269.7694199695 0.11881427502242567 0.03418436684699791 5.409476634444113e-09 8.266844750747024 -0.29436457065908184 DLADELALVDVIEDK ddPTM_A459_Selumetinib_30min_R2 1 DLADELALVDVIEDK 15 0 P00338;P00338-3;P00338-5;P00338-4;P00338-2;F5GYU2;F5GXY2;F5GXH2;F5H5J4;F5H6W8;F5GZQ4 P00338 LDHA L-lactate dehydrogenase A chain 0 117.79 0.029082 24890000.0 2984.6 4534.2 3374.0 4165.4 4523.9 3033.4 3041.6 2328.5 4349.8 3758.8 False True 2818.7278803004365 4881.958560249091 3156.920513333443 3598.0653342842097 3955.567237820865 3451.223315536443 3183.0404268160623 2335.2755494960747 5219.881543566741 3650.2736774647424 0.7721963144029663 1.337422613101109 0.8648448835009126 0.9856974167436143 1.0836358003074884 0.945469742951836 0.8720004876529719 0.6397535516071263 1.4299973111035753 1.0 11.833788918057374 -6.81509353169027 24.531283405908457 0.9483383727240919 1.0177422451504547 0.0 0.2295559493944816 432.63843835156064 197802.76330302114 0.07760594368931978 0.06844207350606864 1.5307577550321766e-07 6.81509353169027 0.06940387242636281 DLAGAPPGEVVGCFT(ph)PQSR ddPTM_A459_Selumetinib_30min_R2 1 DLAGAPPGEVVGCFTPQSR 19 0 Q9Y446;Q9Y446-2 Q9Y446 PKP3 Plakophilin-3 1 DLAGAPPGEVVGCFT(0.968)PQS(0.032)R 159.5 4.8919e-06 7165200.0 25855.0 24380.0 19956.0 28882.0 25082.0 21756.0 20579.0 20638.0 17934.0 21707.0 True False 24418.08260576552 26249.867605944357 18672.052686449955 24948.221775770988 21930.97492407499 24752.69151869548 21535.964276514896 20698.05316319519 21521.301117827465 21080.262508440774 1.1583386400424684 1.2452343795734808 0.8857599699706518 1.1834872438510402 1.0403558739030685 1.1742117304651318 1.0216174617318763 0.9818688526723733 1.020921874630835 1.0 14.36360521223936 -1.522878745280401 0.20938032036117535 0.9918897364904513 1.9150442454340784 0.2231717788457409 0.0943017933711141 81.11703887139107 1.007988393702395 0.159206229663632 24.912122045666038 0.029999999999995624 1.522878745280401 0.923154508943627 DLAGS(ph)IIGK ddPTM_A459_Selumetinib_30min_R2 2 DLAGSIIGK 9 0 P61978;P61978-2;P61978-3;S4R359 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 DLAGS(1)IIGK;DLAGS(1)IIGK 82.494 0.041196 7650400.0 156973.0 169052.0 193542.0 180694.0 195419.0 117291.0 128563.0 155081.0 123291.0 166769.0 True False 148249.0690727066 182017.7448121458 181089.71843259636 156083.165485464 170868.71815197417 133446.77058831183 134541.43424275145 155532.26003495837 147952.64503836673 161953.94565210125 0.9153779395481073 1.123885831118584 1.1181556442076521 0.9637503109726733 1.0550451084348575 0.8239797434449257 0.8307388480164877 0.9603486930109284 0.9135476412299878 1.0 17.305224091093393 -6.745708628676245 24.999870562324194 0.8985582685555173 1.0408020497358275 0.412061549167661 0.07697541752711774 227.622160858729 361744.66122699034 0.025694762083968217 0.02561094442434273 1.7959381306743973e-07 6.745708628676245 0.1422437811803101 DLAVPAALT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 DLAVPAALTPR 11 0 Q8TEM1 Q8TEM1 NUP210 Nuclear pore membrane glycoprotein 210 1 DLAVPAALT(1)PR;DLAVPAALT(1)PR 122.46 0.0096947 14633600.0 5271.799999999999 8326.8 6466.6 6722.0 7281.8 6815.8 8419.400000000001 7726.5 3262.1000000000004 6854.4 True False 5394.622682862879 7351.894384975698 5588.471238491196 5548.128887567644 6623.1624757062045 6747.239240251255 7784.317879502175 7521.568120790913 5535.5454456426205 7734.229007509959 0.6974997349606127 0.9505659035744852 0.7225634556546974 0.7173473764715778 0.8563442418468724 0.8723867930080252 1.0064762592294048 0.9725039319998733 0.7157203956939456 1.0 12.917041767353762 -6.646910048802239 2.6265834318949643 0.9202637778012286 0.7820639340906743 0.29526478911966314 0.10204426287681018 0.37908314299679047 5.311967928359334 0.03690705236963943 0.036595179349246436 2.2547061591805886e-07 6.646910048802239 -0.13819984371055427 DLAVPAALT(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 DLAVPAALTPR 11 0 Q8TEM1 Q8TEM1 NUP210 Nuclear pore membrane glycoprotein 210 1 DLAVPAALT(1)PR;DLAVPAALT(1)PR 121.21 0.010542 21735000.0 61828.0 26971.0 57715.0 58197.0 30040.0 33898.0 93542.0 58331.0 64086.0 42014.0 True False 58391.84727709419 29039.588974566253 54001.6797353407 50270.46820457533 26266.106638992624 38567.14180459363 97891.8883499567 58500.73355278313 76904.99071245073 40800.94665451837 1.4311395216274418 0.7117381177564016 1.3235398725573555 1.232090731380329 0.6437621867306323 0.9452511514294151 2.3992553206879084 1.4338082409738564 1.8848825093114387 1.0 15.316315005225025 -7.214766776812713 24.999509444714384 1.7156381172909114 1.0351677930486973 0.3681772531335089 0.4040004327201265 401.2478425897018 214922.8366444318 0.146530158921418 0.11350148520490407 6.098643163562673e-08 7.214766776812713 -0.6804703242422141 DLDDIEDENEQLKQENK ddPTM_A459_Selumetinib_30min_R2 1 DLDDIEDENEQLKQENK 17 1 Q96IZ0;H0YHP5 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 0 120.54 0.0041213000000000005 4140000.0 21025.0 19589.0 24041.0 24732.0 24796.0 21159.0 27779.0 17882.0 17119.0 23959.0 False True 19856.514669743578 21091.413311437416 22494.228233861675 21363.458934920298 21680.90480094745 24073.460187721903 29070.778543044227 17934.033659475528 20543.27834482484 23267.241417042067 0.8534107810133303 0.9064853427784968 0.9667767583906961 0.9181775592560214 0.9318210273551076 1.0346503806028902 1.2494295315022332 0.7707846984533269 0.8829271152779606 1.0 14.506012553340938 -4.619509089454711 0.8310344697046634 0.9777417024731407 0.7537894519037205 0.09872661710161257 0.11579292741934684 8.308559900831566 3.693033815528158 0.045549417380360245 1.82362224709178 2.4015460048199933e-05 4.619509089454711 -0.22395225056942025 DLDEDELLGNLSET(ph)ELK ddPTM_A459_Selumetinib_30min_R1 2 DLDEDELLGNLSETELK 17 0 Q9NYL9;H0YNU8 Q9NYL9 TMOD3 Tropomodulin-3 1 DLDEDELLGNLS(0.216)ET(0.784)ELK;DLDEDELLGNLS(0.082)ET(0.918)ELK 176.17 2.2147e-07 11543100.0 3914.1000000000004 4768.7 2811.3 2713.0 2602.8 2869.1 3848.3 3598.7 2153.27 4378.6 True False 4005.2909144871915 4210.378387091516 2429.5409013655244 2239.2254793173183 2367.3771995616626 2840.239458934368 3558.019632715897 3503.2507857749606 3653.941921381588 4940.635961175759 0.8106832695145634 0.8521936083081786 0.4917465930413033 0.45322616297041113 0.4791644675229787 0.5748732513897777 0.7201541786675514 0.7090687946458752 0.7395691465825046 1.0 12.270481042865061 -8.67367064306221 0.8938839497355603 0.9967310980697627 0.6118318565889631 0.4341407514125908 0.12882639661518308 0.8412799611386311 1.4105472305518354 0.1414058706887983 0.04843079742716775 2.119968251133358e-09 8.67367064306221 -0.38489924148079957 DLDEEGS(ph)EK ddPTM_A459_Selumetinib_30min_R2 2 DLDEEGSEK 9 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 DLDEEGS(1)EK;DLDEEGS(1)EK 124.42 0.0053143 137683300.0 225798.0 100328.0 145342.0 162533.0 130193.0 176144.0 356839.0 320259.0 239898.0 93371.0 True False 213249.05110101134 108022.83499463415 135990.85395640472 140395.72501493606 113836.99139981244 200406.23712397012 373432.7205630647 321190.9006682684 287884.3033101692 90675.13662300723 2.3517918918349126 1.1913170359340295 1.499759019077115 1.5483376176056745 1.2554377709195343 2.210156439655372 4.1183585100693705 3.542215789579211 3.174897927169195 1.0 16.468419393499474 -7.023543345189175 6.395077306018293 3.1758092840487615 1.5576575579251146 0.38245129408361533 0.8135917042183997 0.15227215381311124 23.359232063084573 0.2894584311955802 0.23303788055423433 9.472326402982288e-08 7.023543345189175 -1.6181517261236469 DLDEEGS(ph)EKELHENVLDK ddPTM_A459_Selumetinib_30min_R1 2 DLDEEGSEKELHENVLDK 18 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 DLDEEGS(1)EKELHENVLDK;DLDEEGS(1)EKELHENVLDK 61.495 0.024934 22191000.0 3891.4 4562.0 2375.1 2111.9 2658.0 3182.9 4882.200000000001 5680.700000000001 3527.9 7187.1 True False 3982.062048653706 4027.8789191837404 2052.5744654904324 1743.0963102728517 2417.5843693080137 3150.882915841971 4513.931723318229 5530.0293824858545 5986.588632378709 8109.634293282397 0.4910285599379297 0.4966782438660924 0.25310320925207186 0.21494141994994062 0.2981126252894802 0.38853575906030685 0.5566134747971727 0.6819086018547896 0.7382069789925904 1.0 12.985421141747798 -8.012151553598551 0.9187529546047429 0.9679157440952124 0.34206371901866606 0.8371823151354204 0.09351523860954664 0.23264227299892015 0.3750543417835265 0.09851636674695502 0.03768742244808107 9.724078282087955e-09 8.012151553598551 -0.6258520250765464 down DLDEEGS(ph)EKELHENVLDK ddPTM_A459_Selumetinib_30min_R2 3 DLDEEGSEKELHENVLDK 18 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 DLDEEGS(1)EKELHENVLDK;DLDEEGS(1)EKELHENVLDK;DLDEEGS(1)EKELHENVLDK 75.143 0.008623899999999999 53936700.0 190114.0 98869.9 125751.9 160584.3 146505.7 151213.4 306497.0 324672.0 201522.0 98383.3 True False 179548.2249666412 106452.9034131646 117661.15966231634 138712.44131663113 128100.34418842418 172041.6732714244 320749.71781228407 325616.74176765705 241832.03099513982 95542.71849848815 1.8792455122520126 1.114191694418336 1.2315031591253935 1.4518368693771895 1.3407651174427406 1.8006780210482158 3.357134095125832 3.408074910206889 2.531140361041397 1.0 16.543858306269563 -7.07178977154674 4.948217348325407 2.76838676058262 1.3939358256552847 0.40278394762962744 0.6554137616735496 0.1822665748194796 8.342500119677702 0.24307884592521048 0.1895529014280371 8.476376298635387e-08 7.07178977154674 -1.3744509349273353 DLDEEIFDDDDFYHQLLR ddPTM_A459_Selumetinib_30min_R1 1 DLDEEIFDDDDFYHQLLR 18 0 Q9NY61;A0A087WTH8;A0A087WWS8 Q9NY61 AATF Protein AATF 0 197.15 3.4747e-10 4186000.0 1295.6 1506.4 1307.3 1509.3 1504.0 1275.0 1449.8 1609.5 725.83 1316.5 False True 1325.7849592012487 1330.029987693639 1129.7758404848826 1245.7290880698968 1367.9634655527668 1262.1746576073756 1340.440418759323 1566.8108316071923 1231.68049747426 1485.4855987959352 0.8924926369369502 0.8953503075167466 0.7605431122325426 0.838600582247062 0.9208863866883488 0.8496714196559261 0.9023584071402786 1.0547465642731075 0.8291433444205735 1.0 10.536718903536931 -7.528500202177313 24.97009849206272 0.9608774838247762 0.8600018083845998 0.3197274527890648 0.06645654435703326 178.801611888506 794207.3926268904 0.030379516758576343 0.017605465882124128 2.9614185867634617e-08 7.528500202177313 -0.1008756754401764 DLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDK ddPTM_A459_Selumetinib_30min_R2 1 DLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDK 32 0 Q15029-3;Q15029;K7EIV5;K7EIT3 Q15029-3 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 86.89 9.5361e-08 8915100.0 29538.0 23429.0 29597.0 30978.0 30869.0 25771.0 30176.0 28739.0 27765.0 27634.0 False True 27896.396209982686 25225.928963891325 27692.761242777062 26758.742959969335 26990.96024763858 29320.721324154307 31579.243792609617 28822.625732002434 33318.77581891826 26836.13461824537 1.0395087298085195 0.9399985997514225 1.0319206412069974 0.9971161398846383 1.0057692969421888 1.0925836280542323 1.1767433813340427 1.0740229970528798 1.2415638948339998 1.0 14.711889265369075 -6.844177262075127 3.476979800130267 1.1299757192415343 0.9997353201064315 0.4457719616291024 0.06402258633733629 0.19798838426036713 4.730492480727719 0.021877402980285315 0.019461460993655325 1.4316034552933098e-07 6.844177262075127 -0.13024039913510277 DLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKK ddPTM_A459_Selumetinib_30min_R2 2 DLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKK 33 1 Q15029-3;Q15029;K7EIV5;K7EIT3 Q15029-3 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 ; 84.905 1.0249e-08 28851000.0 87518.0 71501.0 74248.0 77512.0 90029.0 70244.0 63899.0 75833.0 54212.0 74408.0 False True 82654.09992231242 76984.89678804859 69470.96451511008 66954.7318843419 78718.7521505283 79919.47338845572 66870.4301134664 76053.66147517103 65055.9148098396 72259.64770479835 1.1438486423290968 1.0653926393684376 0.9614074621415144 0.9265853627998774 1.089387433386297 1.1060041935846405 0.9254187120680623 1.0525052901706957 0.9003076665362654 1.0 16.140902600611263 -4.95073397772636 3.3745610928913585 0.9996903068823949 1.1423424127442436 0.3287534677013175 0.06676799636079545 0.31347604275601076 6.849778752775529 0.017436107950016225 0.09303677857584836 1.1201237927928202e-05 4.95073397772636 0.14265210586184873 DLDENEVERPEEENASANPPS(ph)GIEDETAENGVPKPK ddPTM_A459_Selumetinib_30min_R2 1 DLDENEVERPEEENASANPPSGIEDETAENGVPKPK 36 2 Q6UN15;A0A0B4J203 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 DLDENEVERPEEENAS(0.017)ANPPS(0.842)GIEDET(0.141)AENGVPKPK 51.659 0.002108 5980600.0 16362.0 12377.0 13415.0 14295.0 13441.0 10948.0 13825.0 11005.0 8399.9 12020.0 True False 15452.6655422756 13326.2761016724 12551.893505147631 12347.99633974955 11752.421415935421 12455.987623951007 14467.889893717787 11037.022728024176 10080.114712815823 11672.951368289401 1.3238010726451002 1.14163725018802 1.0752973356203601 1.0578298452689496 1.0068080509494717 1.0670812574263602 1.239437177218187 0.9455211779608043 0.8635446507726693 1.0 13.51088175516768 -1.5228787456560762 0.6929162301830165 1.0245849096288686 36.45186042154418 0.5099363842093022 0.0900337412044922 253.4544880142928 1.3841232399303227 0.03833617265502252 13893.871991455078 0.029999999974044896 1.5228787456560762 35.42727551191531 DLDIIDNYDYSHTVK ddPTM_A459_Selumetinib_30min_R1 2 DLDIIDNYDYSHTVK 15 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 ; 177.39 2.7401e-05 10735700.0 6655.1 7860.2 8049.6 8413.3 6513.6 6844.8 6807.2 6624.5 4730.9 7309.8 False True 6810.150881429633 6939.924129892158 6956.508533287778 6944.075092200663 5924.446030069479 6775.947526581146 6293.727423491838 6448.796740591396 8027.991768735066 8248.084033481604 0.8256645851066815 0.8413983298085703 0.8434090274843334 0.8419015936322238 0.7182814828292562 0.8215177608612393 0.763053261574881 0.7818539086669914 0.9733159526681453 1.0 13.009843315970144 -8.29722738520306 6.216051895553067 0.9908107001074445 0.8046448714596716 0.7796322065775192 0.038722939168778954 0.10115660307359971 11.683848724077457 0.037713587369809405 0.01029147832716019 5.043971393000861e-09 8.29722738520306 -0.18616582864777298 DLDIIDNYDYSHTVK ddPTM_A459_Selumetinib_30min_R2 2 DLDIIDNYDYSHTVK 15 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 ; 194.77 4.609899999999999e-05 14194500.0 129453.0 112774.0 132025.0 127333.0 136502.0 97419.0 102007.0 106775.0 89403.0 122422.0 False True 122258.52050141821 121423.40317443691 123530.65523795158 109990.02573832306 119353.39841663682 110837.58296836706 106750.5276230358 107085.69757244726 107286.09812853418 118887.35876944457 1.0283559309153403 1.021331489161185 1.0390562673489252 0.9251616561826738 1.0039200101004517 0.93229073398217 0.8979131905020664 0.9007324132763014 0.9024180471246869 1.0 16.85923579666767 -6.075896133896102 0.8879999937435206 0.9186550287578215 1.0363447186119152 0.5123760339164112 0.038637949339216236 0.4836479959426951 0.785772478141777 0.01785689866619645 0.036952646867809365 8.396607762347137e-07 6.075896133896102 0.11768968985409378 DLDIT(ph)SPELR ddPTM_A459_Selumetinib_30min_R2 1 DLDITSPELR 10 0 P19474-2;P19474 P19474-2 TRIM21 E3 ubiquitin-protein ligase TRIM21 1 DLDIT(0.588)S(0.412)PELR 98.156 0.046451 819660.0 15356.0 13473.0 15489.0 16848.0 16405.0 12675.0 11494.0 10851.0 13750.0 14266.0 True False 14502.574994938517 14506.335777476954 14492.4546031481 14553.2733355789 14344.05723743922 14420.866197805895 12028.49377492892 10882.574613520248 16500.3842070998 13854.103512480579 1.0468071775177483 1.0470786337353988 1.0460766797427534 1.050466623298178 1.035365242111643 1.0409093727944752 0.8682260648690084 0.7855127257939566 1.191010605069848 1.0 13.75802573779255 -7.162598230615824 9.464264348628243 0.9434006690231798 1.0447708685376034 0.1390474212560583 0.09758741166673973 0.653408476264772 58.18176963940536 0.03638033973004677 0.028174815772487413 6.877043467544108e-08 7.162598230615824 0.10137019951442361 DLDITS(ph)PELR ddPTM_A459_Selumetinib_30min_R2 1 DLDITSPELR 10 0 P19474-2;P19474 P19474-2 TRIM21 E3 ubiquitin-protein ligase TRIM21 1 DLDIT(0.037)S(0.963)PELR 100.09 0.017800999999999997 1554100.0 20072.0 15989.0 20637.0 20861.0 18586.0 19084.0 15341.0 18027.0 14686.0 19262.0 True False 18956.478594582306 17215.30488726187 19309.237887866686 18019.695812767764 16251.060519051838 21712.64777269646 16054.386897614795 18079.455585469488 17623.610361124916 18705.856011313674 1.0133980814947496 0.9203163371325916 1.0322563092642258 0.9633184282969511 0.8687686096387609 1.160740666428963 0.8582545962026428 0.9665131376257079 0.9421440189888025 1.0 14.19120236709121 DLDLEPLS(ph)DLEEGLEETR ddPTM_A459_Selumetinib_30min_R1 1 DLDLEPLSDLEEGLEETR 18 0 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 DLDLEPLS(0.997)DLEEGLEET(0.003)R 86.22200000000002 0.020589 0.0 175.41 343.86 181.41 51.364 144.36 0.0 185.54 123.9 65.65 202.84 True False 179.49671171155532 303.60071134382287 156.77551841380134 42.3942416216936 131.3026634888281 0.0 171.544568420889 120.61376951608027 111.4032551137114 228.8764898289158 0.7842514180715038 1.3264827312353624 0.6849786910441975 0.18522759438238115 0.5736834901084698 0.0 0.7495071623525764 0.5269819089161956 0.4867396174984371 1.0 7.8384254667827795 -5.490677961676946 7.537030370573604 0.4723516711848059 1.0459952989591215 0.3641635789149599 0.286627727526313 0.21557771071349113 42.09404685474793 0.07137973509172023 0.1443792667913649 3.23088900456438e-06 5.490677961676946 0.5736436277743155 DLDLLASVPS(ph)PSSSGSR ddPTM_A459_Selumetinib_30min_R1 2 DLDLLASVPSPSSSGSR 17 0 A0A087WV97;Q8WU79-3;Q8WU79-2;Q8WU79 A0A087WV97 SMAP2 Stromal membrane-associated protein 2 1 DLDLLASVPS(0.987)PS(0.013)SSGSR;DLDLLAS(0.026)VPS(0.965)PS(0.009)SSGSR 245.04 2.865e-23 25085900.0 7633.0 9760.599999999999 8430.3 8071.9 8575.9 7324.1 9668.2 8292.2 4657.3 6995.299999999999 True False 7810.834048767472 8617.824414420162 7285.511564323188 6662.2941933289585 7800.211359198124 7250.426203750728 8938.919890087524 8072.263919138339 7903.097944266386 7893.2148949921875 0.9895630807825869 1.0918015699645653 0.923009402537038 0.8440533143923168 0.9882172806604989 0.9185643999570727 1.1324815058258173 1.0226839160631174 1.001252094286761 1.0 12.946397312199373 -7.2362533138034575 24.97547867050109 1.0409947365440753 0.9596685788987878 0.24358690644337944 0.0689444309900178 1182.85044994591 1172962.4841503347 0.02810178362047676 0.021756183880389118 5.804257700057926e-08 7.2362533138034575 -0.0813261576452875 DLDLLASVPS(ph)PSSSGSR ddPTM_A459_Selumetinib_30min_R2 2 DLDLLASVPSPSSSGSR 17 0 A0A087WV97;Q8WU79-3;Q8WU79-2;Q8WU79 A0A087WV97 SMAP2 Stromal membrane-associated protein 2 1 DLDLLASVPS(0.985)PS(0.013)S(0.001)SGSR;DLDLLAS(0.002)VPS(0.95)PS(0.037)S(0.004)S(0.002)GS(0.006)R 166.36 1.4888e-06 16004700.0 74982.0 58803.0 75883.0 84983.0 79938.0 48523.0 55926.0 59403.0 48458.0 56778.0 True False 70814.80061672833 63313.00101855401 71000.7703951636 73408.16879614815 69895.47378521282 55206.60280206197 58526.66981526662 59575.85289530392 58150.954029646695 55138.67161303957 1.2843037118068974 1.1482503870039067 1.2876764767465463 1.3313372747048204 1.2676307161647953 1.001232006267745 1.0614450457929754 1.0804731262552763 1.054631029883113 1.0 15.750776890271412 -6.755013533516754 24.990433132471722 1.0459538550824965 1.262492251425433 0.836458629282496 0.04954381774772062 64.19050714742576 249639.82841953644 0.01753071815522688 0.01713147706532547 1.7578688342665927e-07 6.755013533516754 0.2165383963429366 DLDRPESQS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DLDRPESQSPK 11 1 Q8WUA4;A0A087WZD8;Q8WUA4-2 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 DLDRPES(0.036)QS(0.964)PK 136.33 0.006760600000000001 99282000.0 4431.4 4626.4 5689.0 5615.2 3394.9 4231.4 3992.6 4273.4 2605.6 4138.7 True False 4534.642997996613 4084.7389372449893 4916.465047440138 4634.610730358499 3087.831894418275 4188.835957803804 3691.434967539297 4160.055550040495 4421.512894505504 4669.942459351874 0.9710275956218015 0.8746872092749289 1.0527892131935341 0.9924342260529097 0.6612141201514558 0.8969780664888876 0.7904669061065088 0.8908151623388215 0.9468024355741529 1.0 12.189189058554385 DLDRPESQS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 DLDRPESQSPK 11 1 Q8WUA4;A0A087WZD8;Q8WUA4-2 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 DLDRPES(0.001)QS(0.999)PK;DLDRPES(0.067)QS(0.933)PK;DLDRPES(0.452)QS(0.548)PK 141.65 0.0046841 109922600.0 111116.0 101393.0 97893.0 87725.0 87556.0 81645.0 99704.0 83095.0 52667.0 82093.0 True False 104940.61755259104 109169.5170701197 91594.67095783957 75776.70366593415 76556.43251942874 92890.85765048221 104340.43355972797 83336.79269288211 63201.87163893271 79722.76178677037 1.3163193948708067 1.369364465346908 1.1489149259884182 0.9505027418469207 0.9602832466365074 1.1651736037310367 1.3087910054947796 1.0453324850408214 0.7927707247269596 1.0 16.282704068992125 -5.415675819518458 3.7967580190850914 1.0476391335751984 1.3410883754854563 0.46969899827419614 0.12996262900997785 0.22750728171241055 5.795140103247238 0.03805141301929323 0.08504307636857901 3.839937718981078e-06 5.415675819518458 0.2934492419102579 DLDSLHR ddPTM_A459_Selumetinib_30min_R1 3 DLDSLHR 7 0 Q8NBS9-2;Q8NBS9 Q8NBS9-2 TXNDC5 Thioredoxin domain-containing protein 5 0 ;; 113.89 0.019592 16515800.0 15210.6 18893.8 18574.4 20543.6 21898.4 18089.0 20324.7 17726.800000000003 6413.7 12538.5 False True 15564.977385324564 16681.705112510674 16052.098501875915 16956.045911132784 19917.693586476533 17907.041083497905 18791.591515490152 17256.62767923851 10883.580461885926 14147.938610332583 1.1001586742790277 1.179090860652139 1.1345892107669082 1.198481727843332 1.4078159465528184 1.2656996596253223 1.3282211658570666 1.219727350713522 0.7692696979853576 1.0 13.788304243681065 -8.247519698726947 24.294240069168126 0.8846348786153135 1.2338417709406384 0.6572721311457205 0.09948723777050637 286.548485226522 500120.6516630534 0.07134167906141019 0.026639060179893242 5.6556210374428154e-09 8.247519698726947 0.34920689232532487 DLEAEHVEVEDTTLNR ddPTM_A459_Selumetinib_30min_R1 2 DLEAEHVEVEDTTLNR 16 0 H3BV85;H3BTW0;A0A0B4J295;A0A087WZT3;H3BVE0;Q9H3K6-2;Q9H3K6 H3BV85 BOLA2B;BOLA2 BolA-like protein 2 0 ; 244.0 9.8569e-22 19588000.0 13846.5 15845.3 15559.3 16296.699999999999 14996.2 13536.0 14509.4 13524.599999999999 8714.7 12260.0 False True 14169.096509401117 13990.124909719883 13446.432521117134 13450.787271946387 13639.796357794155 13399.840129704655 13414.94427641505 13165.883673907812 14788.209403495217 13833.69042251285 1.024245597280566 1.0113082252406382 0.9720061755346575 0.9723209686734547 0.9859839233930555 0.968638137795671 0.9697299756385805 0.9517260594816945 1.0689995909861472 1.0 13.755898456069012 -8.258390237849817 24.99601565712164 1.0344997943181622 0.9815954868293889 0.4049172592681003 0.025456724867388793 255.9699712237847 2098419.765418116 0.01927402022094313 0.006574930598669189 5.515815896725334e-09 8.258390237849817 -0.05290430748877328 DLEAEHVEVEDTTLNR ddPTM_A459_Selumetinib_30min_R2 2 DLEAEHVEVEDTTLNR 16 0 H3BV85;H3BTW0;A0A0B4J295;A0A087WZT3;H3BVE0;Q9H3K6-2;Q9H3K6 H3BV85 BOLA2B;BOLA2 BolA-like protein 2 0 ; 138.28 0.00056915 14958200.0 88586.0 90218.0 93710.0 99065.0 114508.0 79788.0 76579.0 84648.0 79439.0 96985.0 False True 83662.74475785517 97137.43050340792 87680.80062373333 85572.17610334286 100122.48132549158 90778.07275664981 80140.07523840983 84894.31166576924 95329.01971111285 94184.79105270778 0.8882829576065603 1.0313494293260976 0.9309443663220034 0.9085562026193261 1.0630429839724436 0.9638294223729658 0.8508812765063286 0.9013590274703759 1.012148762508426 1.0 16.523206491995516 -7.036006137583182 24.918358888190344 0.9292312119606417 0.9682125479469244 0.01511422021551756 0.06566180495702553 1681.5894514828335 1163753.2626196158 0.02490187027485364 0.019296734311914785 9.204365637686637e-08 7.036006137583182 0.03898133598628262 DLEAHIDSANK ddPTM_A459_Selumetinib_30min_R1 3 DLEAHIDSANK 11 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;; 126.71 0.0056755 16071200.0 32111.9 36685.6 35861.7 38723.8 37789.9 33242.0 35928.8 33288.9 17143.5 30072.6 False True 32860.04479111961 32390.432897327253 30991.878114217634 31961.415265753025 34371.81021734872 32907.615661321084 33218.66168955719 32405.970234413584 29091.26738830026 33932.71114192986 0.968388427723219 0.9545489236580083 0.9133333904440571 0.9419057360924824 1.0129402886077168 0.969790345477521 0.9789568994535679 0.9550068103568148 0.8573222241694934 1.0 15.050389082063987 -4.7656093271551905 7.572754931340077 0.9538384729526049 0.968595151240146 0.010836766787099994 0.041963474725301805 0.7644455089942116 326.88388383440554 0.010600051094737958 0.058628389666230865 1.7154998042836518e-05 4.7656093271551905 0.014756678287541014 DLEAHIDSANK ddPTM_A459_Selumetinib_30min_R2 1 DLEAHIDSANK 11 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 109.39 0.013242 8753300.0 269200.0 226930.0 249510.0 262650.0 269780.0 217230.0 243560.0 236740.0 197890.0 291930.0 False True 254238.94169298318 244334.80130504345 233456.7982459478 226876.61690347808 235887.82453619965 247151.46068239672 254886.02260498411 237428.87420558312 237473.52950858008 283501.2223747695 0.896782523769497 0.8618474349364509 0.8234772192175371 0.8002668030953407 0.8320522308872864 0.8717826985439913 0.8990649862808774 0.837488008752633 0.8376455223697628 1.0 18.112995430098906 -6.865743828148731 5.203157484794598 0.8806200268532833 0.8406086663540068 0.17375028565218986 0.04890456242866884 0.4586326264938062 19.391520451437714 0.01744774186872046 0.015414973071121192 1.3622479776952067e-07 6.865743828148731 -0.04001136049927656 DLEDSLAR ddPTM_A459_Selumetinib_30min_R2 3 DLEDSLAR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;; 171.38 0.0022481 22346600.0 166185.0 136537.0 169288.0 164734.0 174249.0 133863.0 152222.0 152546.0 128714.0 145158.0 False True 156949.10299126443 147008.94886434876 158396.19438683824 142296.94501799977 152358.2828141753 152301.41316267403 159300.62462217073 152989.88360465033 154460.39656964663 140966.91137422217 1.113375482666387 1.0428613880464963 1.1236409512183103 1.009435076861738 1.0808088318663143 1.0804054063322872 1.1300568556778434 1.085289321538095 1.0957209395019203 1.0 17.10499703849053 -6.510916353194126 24.481779764154208 1.0861654526263587 1.0702928157499347 0.0 0.04316767414656367 1996.2601124321745 4085467.6562470538 0.013045016746939442 0.014045305984128032 3.083781841427914e-07 6.510916353194126 -0.01587263687642393 DLEEDHACIPIK ddPTM_A459_Selumetinib_30min_R2 2 DLEEDHACIPIK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 ; 110.84 0.0099061 5409000.0 42132.0 47943.0 53292.0 56127.0 53313.0 48164.0 45878.0 53865.0 42533.0 45886.0 False True 39790.47210775916 51620.07393895774 49863.25073994243 48482.4057755245 46615.34431573281 54798.15381073949 48011.41790553238 54021.73823216921 51040.78847131457 44561.151953854205 0.8929408321617139 1.1584097734370395 1.1189847783014872 1.0879971376352882 1.0460982778004897 1.2297292912778899 1.0774276651387094 1.2123056937152796 1.1454099868012932 1.0 15.443498907932767 -6.715911924917953 24.99999150732341 1.142772581876945 1.071037971507817 0.13094484216278146 0.08922904364161365 261.3013556312206 143484.74013225542 0.02814924568473747 0.02814914729876481 1.9234817721753432e-07 6.715911924917953 -0.07173461036912787 DLEEDHACIPIKK ddPTM_A459_Selumetinib_30min_R2 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 0 81.625 0.023402000000000003 7754800.0 86819.0 113610.0 112840.0 110370.0 121830.0 84519.0 96157.0 89461.0 80562.0 108100.0 False True 81993.94754399375 122323.52168627304 105579.99725090284 95337.41560113028 106524.62622598102 96160.72506290782 100628.49103148073 89721.31669893426 96676.65109035444 104978.87212246945 0.78105190012271 1.1652203839984978 1.0057261534276356 0.9081581243310431 1.014724430471193 0.9160007448996568 0.9585594605558964 0.8546607034819772 0.9209153150128194 1.0 16.679739477078506 -6.776653187594384 24.33237064928279 0.9227267814828807 0.9835415359484437 0.04530479350239747 0.09648476254939088 466.2374483458074 745675.6041975435 0.032894912275264226 0.02912971164681253 1.6724256218871196e-07 6.776653187594384 0.06081475446556306 DLEELVMT(ph)S(ph)RK ddPTM_A459_Selumetinib_30min_R2 1 DLEELVMTSRK 11 1 B1AM31;Q5T1B0 B1AM31 AXDND1 Axonemal dynein light chain domain-containing protein 1 2 DLEELVMT(1)S(1)RK 109.72 0.015066 37116000.0 77263.0 71340.0 67025.0 70002.0 68299.0 74447.0 82517.0 78289.0 59988.0 69040.0 True False 72969.03176829484 76811.54860574519 62712.68447130229 60467.60683981453 59718.66901919301 84701.39848742068 86354.20400433346 78516.80802855839 71987.27620476388 67046.63581253761 1.0883324850528853 1.145643590835941 0.9353591527939887 0.9018738391122554 0.8907034379199339 1.2633206343752397 1.2879722145310886 1.1710775205498956 1.0736896092152974 1.0 16.032877323635454 -6.764566425010706 24.999985850748356 1.1779518547950194 0.9927007828657902 0.3680494184942298 0.10791436329972891 89.54865187956891 715914.3832734895 0.04008417613821149 0.036846463542036134 1.7196243058934934e-07 6.764566425010706 -0.18525107192922918 DLEGSDIDTR ddPTM_A459_Selumetinib_30min_R2 2 DLEGSDIDTR 10 0 P55060-4;P55060-3;P55060 P55060-4 CSE1L Exportin-2 0 ; 152.34 0.0088289 12697300.0 86838.0 81491.0 93994.0 105959.0 100798.0 77714.0 71904.0 99058.0 71728.0 85121.0 False True 82011.89160005676 87741.09766513579 87946.52837292923 91527.20141052979 88134.85409444674 88418.39808254736 75247.67847507296 99346.24238006533 86075.60424777116 82663.33555908165 0.9921193119704287 1.0614270168474502 1.0639121658727593 1.1072285045298336 1.0661903914033866 1.0696204972197427 0.9102908558691232 1.2018174890736169 1.0412791071835066 1.0 16.334959958813023 -4.761451362889475 8.617725006155778 1.0620498530347593 0.9915045772321207 0.07120633937913834 0.0699760180729814 0.2350646968152834 201.7998452414114 0.016765852695814293 0.09663086617639156 1.7320029887842086e-05 4.761451362889475 -0.07054527580263859 DLEHSLQMEAYER ddPTM_A459_Selumetinib_30min_R1 1 DLEHSLQMEAYER 13 0 Q9Y5S2 Q9Y5S2 CDC42BPB Serine/threonine-protein kinase MRCK beta 0 153.49 0.0082086 8272600.0 525.59 954.83 718.79 783.03 707.49 642.83 966.96 716.69 408.96 569.65 False True 537.8352243798888 843.0380597115758 621.1822660308488 646.2885097935276 643.497654417505 636.3637138429405 894.0214286960377 697.6810530627888 693.9752507433878 642.7701263608851 0.8367458323318525 1.3115700701346062 0.9664143378096017 1.0054737818208233 1.001131863518205 0.9900331203097206 1.3908882694310016 1.0854285606158893 1.079663198836583 1.0 9.32815906907939 DLELALS(ph)PIHNSSALPTTGR ddPTM_A459_Selumetinib_30min_R1 4 DLELALSPIHNSSALPTTGR 20 0 A0A087WUU7;Q96GX5-2;Q96GX5-3;Q96GX5 A0A087WUU7 MASTL Serine/threonine-protein kinase greatwall 1 DLELALS(1)PIHNSSALPTTGR;DLELALS(0.974)PIHNS(0.018)S(0.008)ALPT(0.001)TGR;DLELALS(1)PIHNSSALPTTGR;DLELALS(1)PIHNSSALPTTGR 121.35 0.00016321 71318000.0 7887.4 9218.7 11401.800000000001 11628.8 13643.699999999999 8419.7 10408.0 8147.5 4685.2 6513.4 True False 8071.161073791237 8139.370318342642 9853.498185604321 9598.048379611211 12409.629743990876 8335.005462475934 9622.916180471131 7931.401833190182 7950.442206531008 7349.458335888679 1.0981980854804438 1.1074789387670498 1.3407108027931776 1.3059531656560697 1.6885094352317778 1.1340979268872997 1.3093367892815668 1.0791818213948872 1.0817725393050561 1.0 12.84342221013168 -7.798699493937932 5.424182603169147 1.0553264964975186 1.2899221924356499 0.298406214424739 0.16141236107777082 0.26061404849134856 18.86887989864438 0.09420281261264102 0.045605420600234176 1.589646309243831e-08 7.798699493937932 0.23459569593813123 DLELALS(ph)PIHNSSALPTTGR ddPTM_A459_Selumetinib_30min_R2 3 DLELALSPIHNSSALPTTGR 20 0 A0A087WUU7;Q96GX5-2;Q96GX5-3;Q96GX5 A0A087WUU7 MASTL Serine/threonine-protein kinase greatwall 1 DLELALS(1)PIHNSSALPTTGR;DLELALS(1)PIHNSSALPTTGR;DLELALS(1)PIHNSSALPTTGR 87.45700000000002 0.0014042 31447500.0 25969.2 20759.699999999997 38417.4 55865.5 71205.7 38781.2 28420.5 34345.5 39420.0 46011.9 True False 24525.93582694434 22351.902237043607 35945.666309702465 48256.522526637185 62260.203378965365 44122.95827931754 29742.109564152357 34445.43971879638 47305.101486827174 44683.41689372674 0.5488822818826915 0.500228133631868 0.8044520497435146 1.0799649149797246 1.3933626322051995 0.9874571227231309 0.6656185142441056 0.7708774778956596 1.0586724287297846 1.0 15.44745189095599 -5.439544940552425 3.4003326022305234 0.9857220129873789 0.5262540701168036 0.5093472818336917 0.18250189194524669 0.2265286802049384 4.947863419896099 0.05704097044560016 0.12878952271572236 3.634586920959244e-06 5.439544940552425 -0.45946794287057535 DLELPSQEAPS(ph)FQGTESPKPCK ddPTM_A459_Selumetinib_30min_R1 1 DLELPSQEAPSFQGTESPKPCK 22 1 Q6PJF5;Q6PJF5-2;K7EPV3 Q6PJF5 RHBDF2 Inactive rhomboid protein 2 1 DLELPSQEAPS(0.886)FQGT(0.018)ES(0.096)PKPCK 65.25 0.0038673 15738000.0 2249.3 1831.0 3115.8 1838.0 2588.6 2383.6 2324.3 2261.6 1364.4 2351.1 True False 2301.704313624089 1616.6256687911932 2692.6914738642968 1517.027803533075 2354.4615870544494 2359.623148135641 2148.9761796953344 2201.6150212878706 2315.287148166759 2652.8865866533433 0.8676225833414628 0.6093836340099977 1.0150043682271273 0.5718404288993102 0.887509326218366 0.8894549657745985 0.8100520355852454 0.8298941358308277 0.87274260415615 1.0 11.373347285004341 -14.522866368186987 0.11592835356947243 1.63452567308724 0.7132225969941974 0.1930283399044389 0.1233806319874623 250.86229336963444 1.8981992051591552 37.03075795018252 1.240270244321654 3.0000854991502574e-15 14.522866368186987 -0.9213030760930425 DLELPSQEAPSFQGT(ph)ESPKPCK ddPTM_A459_Selumetinib_30min_R2 1 DLELPSQEAPSFQGTESPKPCK 22 1 Q6PJF5;Q6PJF5-2;K7EPV3 Q6PJF5 RHBDF2 Inactive rhomboid protein 2 1 DLELPSQEAPS(0.017)FQGT(0.628)ES(0.355)PKPCK 68.835 0.0069189 17963000.0 103700.0 35378.0 58337.0 62627.0 37515.0 27808.0 108870.0 73578.0 45724.0 44014.0 True False 97936.76914399095 38091.378841800644 54583.660932523075 54097.094562399085 32802.030311644754 31638.299584109387 113932.67072181251 73792.09979850639 54870.07763530407 42743.20145789433 2.291282959711545 0.891168128323843 1.2770138658493468 1.265630386055413 0.7674209977920706 0.7401948966147468 2.6655156103373736 1.7264055400997012 1.2837147374034616 1.0 15.383407349186212 -7.209642333805442 24.99982208442774 1.7294510042683497 1.1772441405296636 0.13044946398757717 0.5750359768675829 606.3297448735351 292644.8520926936 0.2173621450869934 0.16836782304830847 6.171030120565447e-08 7.209642333805442 -0.5522068637386861 DLELPSQEAPSFQGTES(ph)PKPCK ddPTM_A459_Selumetinib_30min_R1 1 DLELPSQEAPSFQGTESPKPCK 22 1 Q6PJF5;Q6PJF5-2;K7EPV3 Q6PJF5 RHBDF2 Inactive rhomboid protein 2 1 DLELPS(0.001)QEAPS(0.016)FQGT(0.287)ES(0.695)PKPCK 51.773 0.023628 4637200.0 2307.6 2095.8 2972.9 1924.4 3054.7 2271.6 2219.4 3257.4 963.94 2274.4 True False 2361.362590192034 1850.422761689013 2569.1965089707846 1588.3396654619419 2778.402924351088 2248.749766447777 2051.9888711508097 3171.0031704736057 1635.735776607935 2566.3413945320754 0.9201280060490878 0.7210353094999674 1.0011125232382536 0.6189120702514898 1.0826318471388248 0.8762473189416775 0.7995775135462645 1.2356123691219887 0.6373804280650591 1.0 11.325497386281034 -6.281103935853737 24.940628055387766 0.9402892596293009 0.8218364897811757 0.10188938285770688 0.17884009676669155 1934.969538978298 2454122.4649317935 0.05188314416195781 0.05891053690678755 5.234751429217753e-07 6.281103935853737 -0.11845276984812514 DLENS(ph)PPLIESSPTLCSEEHAR ddPTM_A459_Selumetinib_30min_R1 1 DLENSPPLIESSPTLCSEEHAR 22 0 H3BMS5;Q6ZVD8-3;Q6ZVD8 H3BMS5 PHLPP2 PH domain leucine-rich repeat-containing protein phosphatase 2 1 DLENS(0.804)PPLIES(0.189)S(0.005)PT(0.001)LCS(0.001)EEHAR 71.042 0.002478 3161400.0 528.5 717.7 693.44 725.35 537.64 451.86 642.67 603.24 276.94 503.01 True False 540.8130217180145 633.6713503503219 599.2746567932659 598.6812390058296 489.0105569280515 447.314698656054 594.1928844834143 587.2401156003251 469.94695310268463 567.5762332323156 0.95284649013246 1.1164515235981574 1.0558487507139427 1.0548032210516862 0.8615768742520509 0.7881138646497251 1.0468952885844396 1.034645359013757 0.8279891327132611 1.0 9.14867036882125 -6.241379897205287 23.833141697826576 0.927365805684353 1.0508679029806054 0.29898942607994006 0.08866602781008306 591.5877808754872 702878.2937632605 0.02722578520440884 0.03509186889899514 5.736144759213136e-07 6.241379897205287 0.12350209729625239 DLENS(ph)PPLIESSPTLCSEEHAR ddPTM_A459_Selumetinib_30min_R2 1 DLENSPPLIESSPTLCSEEHAR 22 0 H3BMS5;Q6ZVD8-3;Q6ZVD8 H3BMS5 PHLPP2 PH domain leucine-rich repeat-containing protein phosphatase 2 1 DLENS(0.986)PPLIES(0.013)SPTLCSEEHAR 84.70700000000002 0.00043568 2761200.0 9297.8 8153.3 9048.8 13312.0 14833.0 10354.0 14221.0 13685.0 8958.4 9952.3 True False 8781.065498042422 8778.631893008449 8466.61005958851 11498.882635519134 12969.545931297524 11780.16951574613 14882.304678376899 13724.821084326288 10750.330318609658 9664.951239819182 0.9085473149481408 0.9082955180198804 0.8760116682954842 1.189750713707094 1.3419152988442977 1.2188545211912027 1.539822013489571 1.4200610788164785 1.112300522978198 1.0 13.23854673864557 -5.872565940544167 3.5400593502826774 1.3020552937261665 0.8964462707321458 0.5689666991337864 0.14439715843875267 0.15568843329895704 3.769730690134274 0.04160746156139649 0.06559174785971743 1.3410163084603665e-06 5.872565940544167 -0.4056090229940207 DLERYNS(ph)QMKRAIEQESQMS(ph)LK ddPTM_A459_Selumetinib_30min_R1 1 DLERYNSQMKRAIEQESQMSLK 22 3 E9PH88;Q3BDU3;Q5FBZ9;E9PC65;B7ZAA0;P54277-3;P54277 E9PH88 PMS1 PMS1 protein homolog 1 2 DLERY(0.469)NS(0.531)QMKRAIEQES(0.438)QMS(0.562)LK 51.487 0.039748 0.0 397.22 709.66 635.44 841.99 846.35 839.03 705.63 652.2 576.45 668.29 True False 406.47445314442757 626.572677288017 549.1507382220713 694.9522526098007 769.7977919352289 830.5901199782874 652.4037609940278 634.9015373558315 978.1935477577904 754.0715311958492 0.5390396485328354 0.8309194172791043 0.7282475408549067 0.9215999064541082 1.0208551312293148 1.1014739127746815 0.8651748992027443 0.8419646029455173 1.297215857236403 1.0 9.558557573755005 -4.28195470546942 0.5242574098441298 1.0281388735855752 1.5860135312176585e-10 0.5660429723167286 0.1301673924761203 5.521152755974999 0.7883006625074637 0.07489628834244172 3.886539988795137 5.224506748953925e-05 4.28195470546942 -1.0281388734269739 DLESAEERR ddPTM_A459_Selumetinib_30min_R1 3 DLESAEERR 9 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 ;; 138.06 0.0033813000000000003 8761500.0 3590.83 3059.31 5129.0 5989.0 5102.5 4554.799999999999 3998.53 3929.1000000000004 2544.9 3230.6 False True 3674.4893524611143 2701.1245629653677 4432.5099715803235 4943.133577453526 4640.979775919545 4508.982847427507 3696.9176628650275 3824.8875044845104 4318.509427858097 3645.27897870881 1.0080132066497283 0.7409925491963663 1.2159590520971204 1.3560371116518573 1.273148036961336 1.2369376593021775 1.0141659073167861 1.049271544599124 1.1846855763527189 1.0 11.83181351507111 -5.272595506605602 24.92665544257074 1.1757205419960612 0.8745028748226802 0.46471856042191284 0.12492807030669632 541.1001821207774 1209006.383806586 0.03474366814509889 0.07339215579525486 5.338318645857255e-06 5.272595506605602 -0.30121766717338105 DLESAQS(ph)LNR ddPTM_A459_Selumetinib_30min_R1 1 DLESAQSLNR 10 0 P78504-2;P78504 P78504-2 JAG1 Protein jagged-1 1 DLESAQS(1)LNR 152.96 0.00061384 12786000.0 2192.0 1643.4 2076.9 1645.3 2119.1 1776.3 2039.9 2158.7 1027.9 1697.5 True False 2243.06933511048 1450.9899640040676 1794.868387595082 1357.9792411060762 1927.4277791574916 1758.432034751357 1886.028700667089 2101.444263554176 1744.271225154364 1915.3906600502098 1.1710766800187282 0.757542570436274 0.9370769237999894 0.7089829085156332 1.0062844198618814 0.9180539883729315 0.984670511350227 1.0971361129531085 0.9106608179391664 1.0 10.903422956622963 -6.93034293555818 1.696848730961129 1.004358540311728 0.8926994261193616 0.0830080193343451 0.12676894730167618 0.7746897462484676 4.5535707763983595 0.05605718662289761 0.044810209705459736 1.17397017702148e-07 6.93034293555818 -0.11165911419236652 DLESAQS(ph)LNR ddPTM_A459_Selumetinib_30min_R2 2 DLESAQSLNR 10 0 P78504-2;P78504 P78504-2 JAG1 Protein jagged-1 1 DLES(0.002)AQS(0.998)LNR;DLES(0.005)AQS(0.995)LNR 101.38 0.016419 26301000.0 70703.0 34078.0 51316.0 68294.0 60982.0 47959.0 64914.0 58362.0 47380.0 46887.0 True False 66773.61030653409 36691.67302195945 48014.384428636295 58992.23938627877 53320.89597400293 54564.91692154424 67932.62962465078 58531.82375765077 56857.32390781008 45533.25048294386 1.4664802006952387 0.8058215179630905 1.0544905957597257 1.2955859456679129 1.171032056979464 1.19835321095698 1.4919345512154338 1.2854743102422699 1.248698990402806 1.0 15.474632832278767 -5.759070756816178 24.99681220362504 1.2591679792257269 1.0786198137722012 0.08162805296864761 0.18983661892190562 114.7774700481367 1211249.7077344733 0.05066555687550792 0.08270156140675912 1.7415231150785262e-06 5.759070756816178 -0.1805481654535257 DLESCS(ph)DDDNQGSK ddPTM_A459_Selumetinib_30min_R1 1 DLESCSDDDNQGSK 14 0 Q5T3I0;Q5T3I0-3;F8W895;A0A0A0MRK1;E9PAV9 Q5T3I0 GPATCH4 G patch domain-containing protein 4 1 DLES(0.003)CS(0.997)DDDNQGSK 154.13 0.00035007 13477000.0 3622.7 4221.5 2260.7 2719.4 3012.4 3021.6 3357.5 3488.1 1989.2 3490.7 True False 3707.10186145289 3727.2448174778956 1953.7093571362152 2244.507839460197 2739.928951882416 2991.2054473932917 3104.2410718612423 3395.584257054396 3375.527114580268 3938.765347297358 0.9411837300733268 0.9462977580107431 0.49602075393416917 0.5698506109281933 0.695631425152671 0.7594271767029106 0.7881254144756968 0.862093564264834 0.8570013232437002 1.0 11.943527755339787 -8.166185434009478 0.9372269527927773 0.9846579286741798 0.7240487933085525 0.2749674172486609 0.13349126483029072 0.7773718591553167 1.3735761941331075 0.13945607140972358 0.05072190385875428 6.820474130029236e-09 8.166185434009478 -0.26060913536562724 DLESCS(ph)DDDNQGSK ddPTM_A459_Selumetinib_30min_R2 4 DLESCSDDDNQGSK 14 0 Q5T3I0;Q5T3I0-3;F8W895;A0A0A0MRK1;E9PAV9 Q5T3I0 GPATCH4 G patch domain-containing protein 4 1 DLES(0.001)CS(0.999)DDDNQGSK;DLES(0.002)CS(0.998)DDDNQGSK;DLESCS(1)DDDNQGSK;DLES(0.001)CS(0.999)DDDNQGSK 181.51 7.493e-05 85381000.0 254376.0 197810.0 243126.0 251940.0 231961.0 200276.0 272095.0 261232.0 194834.0 231423.0 True False 240238.80026780933 212981.39094060086 227483.53785557335 217625.33737925816 202819.98542234927 227862.20107548503 284747.9566460138 261992.1418707141 233806.2441168063 224741.2166808356 1.068957460566668 0.9476739250863122 1.012202128364519 0.9683374531531391 0.9024601202118719 1.0138870138764162 1.2670037158800125 1.1657503049063764 1.040335402512501 1.0 17.777905207980254 -7.021039626998821 24.341598834824712 1.1332792643774448 0.9771726892258075 0.40729662764577035 0.07843483504251829 485.91999580891303 562179.093249767 0.02921330539352698 0.022896069175324732 9.527092305451968e-08 7.021039626998821 -0.15610657515163728 DLESCSDDDNQGS(ph)KSPK ddPTM_A459_Selumetinib_30min_R2 1 DLESCSDDDNQGSKSPK 17 1 Q5T3I0;Q5T3I0-3;F8W895;A0A0A0MRK1;E9PAV9 Q5T3I0 GPATCH4 G patch domain-containing protein 4 1 DLESCSDDDNQGS(0.589)KS(0.411)PK 69.729 0.018485 5309500.0 19920.0 19694.0 18031.0 14184.0 14074.0 11078.0 13344.0 14702.0 7741.3 14450.0 True False 18812.926146078098 21204.46647380919 16870.905090668435 12252.114731235235 12305.898296843623 12603.893943928499 13964.522440634368 14744.780385952883 9289.776309994306 14032.790954391166 1.3406403763316321 1.5110655138188207 1.20224872910183 0.8731060536037759 0.8769387598546702 0.8981744248092334 0.995135072276165 1.0507375499197413 0.6620048955469783 1.0 13.776514351844536 -5.568940598958228 3.386967926191538 0.9124311771518935 1.4206406126274203 0.7914074960523378 0.10805706141333477 0.09651358381997859 2.2712118139282125 0.029453242193255697 0.05818460426692443 2.698108443562874e-06 5.568940598958228 0.5082094354755268 DLESCSDDDNQGSKS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DLESCSDDDNQGSKSPK 17 1 Q5T3I0;Q5T3I0-3;F8W895;A0A0A0MRK1;E9PAV9 Q5T3I0 GPATCH4 G patch domain-containing protein 4 1 DLESCSDDDNQGS(0.169)KS(0.831)PK;DLESCSDDDNQGS(0.012)KS(0.988)PK 84.62 0.0066953 9956900.0 35559.0 34520.0 30593.0 29966.0 22727.1 25466.6 29749.0 24498.5 16711.7 30680.0 True False 33582.773133955365 37167.57300070545 28624.67968713987 25884.579105766683 19871.918515148114 28974.392987222374 31132.387446525172 24569.786579055002 20054.506963911987 29794.188683786906 1.127158503639003 1.2474772646160666 0.9607470769196192 0.86877945831941 0.6669729699994082 0.9724847115232697 1.0449147576039375 0.8246502980772601 0.6731012942408142 1.0 14.862743341959428 -5.429759055974033 3.525231058297984 0.8626800104566243 1.1861095142084208 0.521141483864517 0.12179939571563753 0.19220725018488774 4.417497186384922 0.03449521142028535 0.07775293304957244 3.7174141184775457e-06 5.429759055974033 0.32342950375179647 DLETQPHMQEFR ddPTM_A459_Selumetinib_30min_R1 1 DLETQPHMQEFR 12 0 E2QRI1;Q32P28-2;Q32P28-4;Q32P28;Q32P28-3 E2QRI1 P3H1;LEPRE1 Prolyl 3-hydroxylase 1 0 110.31 0.01069 0.0 1255.9 1506.3 1228.3 1266.3 1645.5 1236.0 1965.5 1174.0 726.61 1169.5 False True 1285.1600264440008 1329.9416957401288 1061.5036065689446 1045.1644763949573 1496.664815536621 1223.5669621982088 1817.240752566871 1142.8617063105582 1233.004100505313 1319.616716894681 0.9738888648426918 1.0078242255597856 0.8044029701797598 0.7920212460284952 1.134166304787779 0.9272138997128678 1.377097402072321 0.8660557961102051 0.9343653234454437 1.0 10.365903243843297 -6.264817415190506 24.988273405016212 1.0443531616185298 0.8961885095130439 0.18946359435522453 0.1470158203098583 527.1060190157506 3899145.449821814 0.04585357629215029 0.054152524295651254 5.434787712165551e-07 6.264817415190506 -0.1481646521054859 DLFAFQES(ph)PPR ddPTM_A459_Selumetinib_30min_R1 3 DLFAFQESPPR 11 0 E7EX48;P51957-3;P51957-2;P51957 E7EX48 NEK4 Serine/threonine-protein kinase Nek4 1 DLFAFQES(1)PPR;DLFAFQES(1)PPR;DLFAFQES(1)PPR 141.58 0.00099208 26603600.0 5213.65 6579.219999999999 6220.65 6460.65 6218.34 4958.6 5532.92 5768.83 2885.34 4808.3 True False 5335.117901003077 5808.921863803604 5375.9198975845475 5332.418758920543 5655.892244937098 4908.720986048575 5115.567389820551 5615.821888599264 4896.211243104279 5425.492141808206 0.9833426648785065 1.0706718786007878 0.9908630880060335 0.9828451722986657 1.0424662126691617 0.9047512848138783 0.942876195580598 1.035080641869223 0.9024455505841856 1.0 12.40553829380315 -6.7444705348848935 24.998059379872043 0.9583385984521872 1.0141637295287407 0.2853328048499819 0.04508620130499303 331.6430828264384 488566.8157875191 0.014583900299372411 0.014548228723753484 1.8010653252574412e-07 6.7444705348848935 0.055825131076553514 DLFAFQES(ph)PPR ddPTM_A459_Selumetinib_30min_R2 3 DLFAFQESPPR 11 0 E7EX48;P51957-3;P51957-2;P51957 E7EX48 NEK4 Serine/threonine-protein kinase Nek4 1 DLFAFQES(1)PPR;DLFAFQES(1)PPR;DLFAFQES(1)PPR 103.14 0.01359 7796400.0 19836.5 23849.8 25257.5 24985.4 27608.9 18508.9 21795.7 17084.1 17278.0 19030.0 True False 18734.06674180111 25679.002970806057 23632.459948286712 21582.345417780933 24140.42315530239 21058.332967934497 22809.2432373602 17133.81190257498 20734.082787656007 18480.554454122062 1.0137177858114805 1.3895147483022832 1.2787744007872839 1.1678407956513999 1.3062607626427518 1.1394859943305145 1.2342293784520424 0.927126507221936 1.1219405153199447 1.0 14.173720420730517 -7.746719503459811 24.963818270155574 1.0184001436310541 1.2258211270504462 0.4342811597898085 0.10551505267566756 194.53802038847365 329923.22836092726 0.047520755142260784 0.02728760054311038 1.7917627210897286e-08 7.746719503459811 0.20742098341939208 DLFDLNS(ph)SEEDDTEGFSER ddPTM_A459_Selumetinib_30min_R1 1 DLFDLNSSEEDDTEGFSER 19 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 DLFDLNS(0.5)S(0.5)EEDDTEGFSER 337.71 1.4815999999999989e-173 7909800.0 2283.1 3038.7 2779.4 3501.3 3112.3 2605.9 2535.6 2426.4 1224.2 1789.3 True False 2336.291787860736 2682.9275913466963 2401.9727461513667 2889.8636825409985 2830.793014521194 2579.687011967889 2344.3376505767296 2362.0439899420276 2077.377987969618 2018.9740842579313 1.1571677943154153 1.328856874521398 1.1896996424469735 1.4313525394275481 1.4020947750607926 1.277721706326927 1.1611529186311398 1.1699228872520129 1.0289275152995105 1.0 10.979406676880496 -7.850186736430724 1.2056092661139737 1.0071811476369583 1.3043016923750872 0.6359634240175556 0.08283188669846044 0.3192933059334132 0.8371356870744262 0.07579569878162942 0.028175026397294488 1.4119303171986633e-08 7.850186736430724 0.2971205447381289 DLFDLNS(ph)SEEDDTEGFSER ddPTM_A459_Selumetinib_30min_R2 3 DLFDLNSSEEDDTEGFSER 19 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 DLFDLNS(0.677)S(0.323)EEDDTEGFSER;DLFDLNS(0.903)S(0.097)EEDDTEGFSER;DLFDLNS(0.904)S(0.096)EEDDTEGFSER 120.08 0.00043886 4937430.0 17212.7 13821.6 18149.399999999998 20138.0 21590.2 13278.0 15737.9 16165.599999999999 13940.3 15824.400000000001 True False 16256.087041897506 14881.672276551297 16981.687363572608 17395.169660012336 18877.84605716307 15106.923974316893 16469.743534057237 16212.639219640858 16728.74952452605 15367.508455271118 1.0578219032195555 0.9683854946210765 1.1050384265608013 1.1319446942647182 1.2284259424427317 0.9830431535656748 1.0717250348027658 1.0549946510086257 1.0885791651403336 1.0 13.907595658397176 -10.351755760871484 14.90412615694793 1.0000000002887302 1.0768657122903624 0.09856088075712888 0.06955082395484058 0.0 0.0 0.0706848056250343 0.017143583512839403 4.448813901388928e-11 10.351755760871484 0.07686571200163228 DLFDLNSS(ph)EEDDTEGFSER ddPTM_A459_Selumetinib_30min_R1 1 DLFDLNSSEEDDTEGFSER 19 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 DLFDLNS(0.098)S(0.902)EEDDTEGFSER 238.88 1.0099e-29 6562100.0 2759.2 3488.1 3736.5 3428.1 3256.8 3021.6 2967.1 2646.8 1822.2 2579.0 True False 2823.483991531401 3079.7116304263054 3229.103823125343 2829.446688406818 2962.2230150347395 2991.2054473932917 2743.2892581740844 2576.598265981929 3092.140311777683 2910.0397715873287 0.9702561522007259 1.0583056838245295 1.1096425054575716 0.9723051609234364 1.0179321409820274 1.0278916036125822 0.94269820122689 0.8854168562020999 1.0625766499717029 1.0 11.506823155280083 -7.248707442000696 22.760775987642855 0.9631243353562438 1.028508433409299 0.16819565839982853 0.0564280484165434 348.67588415133883 623325.2867523219 0.02166259624472204 0.016633304794667868 5.640174724359972e-08 7.248707442000696 0.06538409805305534 DLFDYS(ph)PPLHK ddPTM_A459_Selumetinib_30min_R1 2 DLFDYSPPLHK 11 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 DLFDYS(1)PPLHK;DLFDYS(1)PPLHK 103.83 0.008531200000000001 665010000.0 23614.0 20922.5 17213.7 19873.5 17359.7 17450.0 19642.6 17726.0 10430.5 17024.0 True False 24164.16025515459 18472.883973393637 14876.17408808584 16402.966296797917 15789.518200103961 17274.46884333231 18160.942867652015 17255.848897837273 17699.796686421418 19209.196227802506 1.2579474939290014 0.9616687629364125 0.7744298049574168 0.8539121628138203 0.8219770370845054 0.8992811900338672 0.9454296084167594 0.8983118654835726 0.9214230765576514 1.0 14.229509532992058 -4.7920465856774275 3.6060242202283326 0.8834782457743371 1.2959284356404663 0.7689134587953169 0.060282089677234675 0.12057153616516057 2.6670811255193256 0.015474803621211366 0.13273844699813012 1.6141853979292866e-05 4.7920465856774275 0.41245018986612925 DLFDYS(ph)PPLHK ddPTM_A459_Selumetinib_30min_R2 6 DLFDYSPPLHK 11 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 DLFDY(0.001)S(0.999)PPLHK;DLFDYS(1)PPLHK;DLFDYS(1)PPLHK;DLFDY(0.003)S(0.997)PPLHK;DLFDYS(1)PPLHK;DLFDYS(1)PPLHK 120.57 0.0046911 306668900.0 654330.0 548816.0 649346.0 713086.0 700146.0 571465.0 595356.0 578284.0 514636.0 591293.0 True False 617964.958090527 590908.4224784237 607567.7853144682 615962.456658036 612187.400095344 650179.1165072306 623041.233675533 579966.7106999296 617577.5801312731 574220.8347262862 1.0761799654745936 1.0290612718016265 1.058073390186334 1.0726926287020684 1.0661184044064778 1.132280609109475 1.0850202500445982 1.010006387135678 1.0755053505253842 1.0 19.131246151918475 -8.909308198913571 0.9102773519637616 1.000840794436694 1.0701135772438637 0.29621215200488427 0.03094819489005892 1.7623983291043939 2.50799731278139 0.032123950789811576 0.010576277911568758 1.2322300656032742e-09 8.909308198913571 0.06927278280716975 DLFSLDSEDPSPAS(ph)PPLR ddPTM_A459_Selumetinib_30min_R1 4 DLFSLDSEDPSPASPPLR 18 0 H3BTX0;Q9BTK6 H3BTX0 PAGR1 PAXIP1-associated glutamate-rich protein 1 1 DLFSLDSEDPSPAS(1)PPLR;DLFSLDSEDPSPAS(1)PPLR;DLFSLDSEDPSPAS(1)PPLR;DLFSLDSEDPS(0.05)PAS(0.95)PPLR 383.17 3.843199999999996e-256 213605700.0 6066.6 7253.700000000001 7787.2 8451.8 7461.7 6141.6 6823.4 6473.8 3963.6000000000004 5612.9 True False 6207.939976451295 6404.433431846361 6729.741012027745 6975.851789935167 6786.790552470132 6079.821080126638 6308.70544444914 6302.093794133982 6725.939710109774 6333.370389275888 0.980195313851061 1.0112204147559098 1.0625844689934794 1.1014438381414065 1.0715922384646897 0.9599661327910685 0.9961055578134965 0.9950616191349134 1.0619842669392292 1.0 12.62875773847949 -6.747029263324169 24.998897231992068 1.0019074848690015 1.0475754162958795 0.23252282705900218 0.03875322102573922 378.11538409231264 655959.6698799455 0.013998697486530539 0.013939128057585464 1.7904852047605976e-07 6.747029263324169 0.04566793142687797 DLFSLDSEDPSPAS(ph)PPLR ddPTM_A459_Selumetinib_30min_R2 9 DLFSLDSEDPSPASPPLR 18 0 H3BTX0;Q9BTK6 H3BTX0 PAGR1 PAXIP1-associated glutamate-rich protein 1 1 DLFSLDSEDPSPAS(1)PPLR;DLFSLDS(0.001)EDPS(0.222)PAS(0.777)PPLR;DLFSLDSEDPSPAS(1)PPLR;DLFSLDSEDPSPAS(1)PPLR;DLFSLDSEDPS(0.002)PAS(0.998)PPLR;DLFSLDSEDPSPAS(1)PPLR;DLFSLDSEDPS(0.003)PAS(0.997)PPLR;DLFS(0.003)LDS(0.008)EDPS(0.066)PAS(0.923)PPLR;DLFSLDSEDPS(0.003)PAS(0.997)PPLR 302.9 7.920999999999996e-96 37841700.0 145555.9 140203.0 157086.30000000002 161554.5 168815.3 120880.50000000001 126023.5 132756.8 113367.9 142704.3 True False 137466.48578443422 150956.11927630068 146979.5384806313 139550.49840294282 147607.21278606975 137530.6916310749 131883.84246082776 133143.10030892855 136044.64776378707 138584.05606870065 0.9919357946652072 1.0892747950851345 1.0605804350809933 1.0069736906369884 1.0651096307420533 0.9923990936078277 0.9516523487770384 0.9607389485189058 0.9816760428511725 1.0 17.080401761105612 -6.915189297471344 4.884657528583759 0.9703824279505088 1.0440803008360715 0.5667086704098084 0.028886953295832223 0.14399356699970772 6.033489912875411 0.010203147266150046 0.008935328733692596 1.2156560128664622e-07 6.915189297471344 0.07369787288556273 DLGHPVEEEDELES(ph)GDQEDEDDESEDPGKDLDHI ddPTM_A459_Selumetinib_30min_R2 2 DLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI 34 1 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 1 DLGHPVEEEDELES(1)GDQEDEDDESEDPGKDLDHI;DLGHPVEEEDELES(0.997)GDQEDEDDES(0.003)EDPGKDLDHI 108.69 1.8063e-14 10617500.0 74937.0 59208.0 67416.0 79343.0 76871.0 57974.0 68239.0 68785.0 57111.0 72052.0 True False 70772.30153657905 63749.063216273695 63078.52795699093 68536.3465256908 67213.77774454076 65959.39226442599 71412.24871301335 68985.15296203017 68534.79581466742 69971.67154642146 1.0114422018577391 0.9110696058472822 0.9014866525682841 0.979487055418157 0.9605855664023828 0.9426585188931266 1.020588005613617 0.9859011716800734 0.9794648934347556 1.0 16.094483336014584 -7.245808336850298 24.32533272318645 0.9953136158506379 0.9487644370263629 0.33551060474704686 0.031154495868463795 674.8412557728393 1050201.8348152132 0.012193177541831869 0.00940631366540069 5.677951298742974e-08 7.245808336850298 -0.046549178824275006 DLGLSESGEDVNAAILDESGKK ddPTM_A459_Selumetinib_30min_R2 1 DLGLSESGEDVNAAILDESGKK 22 1 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 73.383 0.022146 0.0 8488.2 11522.0 10840.0 12742.0 11351.0 9128.4 9618.1 11442.0 10625.0 12068.0 False True 8016.459824956835 12405.700350930716 10142.566201699618 11006.517618823975 9924.985900772486 10385.754240635215 10065.360707903588 11475.294325674937 12750.296887304394 11719.565483570426 0.6840236386063162 1.0585461012460042 0.8654387584521293 0.9391574827798805 0.8468731980452904 0.8861893604498331 0.8588510147423251 0.9791569782823492 1.0879496262194142 1.0 13.516631460715836 -7.948238700918397 4.161490668592328 1.042672114691891 0.885564245842975 0.3669078598996247 0.0895108474892885 0.22043743876493102 7.909670400578195 0.05172253513394869 0.022267199484916306 1.1265780857936581e-08 7.948238700918397 -0.15710786884891592 DLGSTEDGDGT(ph)DDFLTDKEDEK ddPTM_A459_Selumetinib_30min_R1 2 DLGSTEDGDGTDDFLTDKEDEK 22 1 Q15527 Q15527 SURF2 Surfeit locus protein 2 1 DLGST(0.002)EDGDGT(0.998)DDFLTDKEDEK;DLGSTEDGDGT(1)DDFLTDKEDEK 139.04 1.5156e-05 14057100.0 2889.17 3547.1400000000003 3429.5699999999997 3325.2000000000003 2377.73 3416.94 2649.7599999999998 3134.69 2036.3600000000001 3245.9 True False 2956.4820396538053 3131.839199779354 2963.8532312795337 2744.516241734591 2162.664741322328 3382.568685933292 2449.8864698659836 3051.5478382918614 3455.5541901501483 3662.5428827434307 0.8072211396032174 0.8550996671016307 0.8092337280866067 0.7493471966337248 0.5904817528586539 0.9235574283295698 0.6689031496147 0.8331773677434998 0.9434849777272131 1.0 11.838629936035636 -8.25491303019143 2.731970820150881 0.9915501127213275 0.7735533238510748 0.4460215620099818 0.0882299124986647 0.2503242159960919 3.4459967256687998 0.079966121970647 0.023085765433236313 5.5601559123857086e-09 8.25491303019143 -0.21799678887025276 DLGSTEDGDGT(ph)DDFLTDKEDEK ddPTM_A459_Selumetinib_30min_R2 3 DLGSTEDGDGTDDFLTDKEDEK 22 1 Q15527 Q15527 SURF2 Surfeit locus protein 2 1 DLGS(0.013)T(0.043)EDGDGT(0.905)DDFLT(0.039)DKEDEK;DLGST(0.001)EDGDGT(0.999)DDFLT(0.001)DKEDEK;DLGS(0.005)T(0.032)EDGDGT(0.962)DDFLTDKEDEK 122.49 4.4958e-05 11566100.0 48510.0 41931.7 43459.0 42047.2 39531.7 31910.5 40855.3 40828.3 29116.8 42864.7 True False 45814.00840091608 45147.72655833375 40662.89525458151 36320.298824534264 34565.374428118004 36305.881720322315 42755.15240324114 40947.103593511056 34940.97359136607 41627.08473513435 1.100581717226233 1.0845757478718632 0.9768374488223761 0.8725160326656021 0.8303577982472533 0.8721696931536309 1.0270993675219988 0.983664934838702 0.839380749665493 1.0 15.345234905468498 -5.369098113475693 3.0019696118520818 0.9164536008623491 1.0970274232832529 0.5343385145365986 0.06435357444391197 0.2102142618337369 3.5818930907897886 0.01886935286501144 0.047595400110869504 4.274663043518649e-06 5.369098113475693 0.1805738224209038 DLGSTEDGDGTDDFLT(ph)DKEDEK ddPTM_A459_Selumetinib_30min_R2 1 DLGSTEDGDGTDDFLTDKEDEK 22 1 Q15527 Q15527 SURF2 Surfeit locus protein 2 1 DLGSTEDGDGT(0.014)DDFLT(0.986)DKEDEK 85.17 0.00088347 3234800.0 40595.0 50554.0 52102.0 38170.0 33015.0 25069.0 32985.0 26597.0 26101.0 42756.0 True False 38338.89241466069 54431.329243269516 48749.81404436839 32971.180153077315 28867.360542155184 28522.027196275834 34518.86785853754 26674.392866629634 31321.92932287357 41521.523186570834 0.9233498550231536 1.3109184120893247 1.1740853972364718 0.7940744371280934 0.695238476980817 0.6869215049774623 0.8313487851452872 0.6424232739914716 0.7543540534901165 1.0 15.341571748423588 -5.791761018770254 5.6935270961134075 0.750443877286093 1.1550292808850715 0.6223302888399915 0.12917739945042747 0.09653253313956403 8.624337498057663 0.034480571102737244 0.05367027120412052 1.6152471418236985e-06 5.791761018770254 0.40458540359897854 DLGTQNHTSELILS(ph)SPPGQK ddPTM_A459_Selumetinib_30min_R2 1 DLGTQNHTSELILSSPPGQK 20 0 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 DLGTQNHTSELILS(0.591)S(0.409)PPGQK 83.87100000000002 0.0018117 4133700.0 11807.0 10757.0 16748.0 30926.0 32706.0 17055.0 13495.0 19451.0 20531.0 20277.0 True False 11150.814207165871 11582.027310793408 15670.451913843657 26713.82544967433 28597.179884650235 19404.17144012462 14122.544239835208 19507.599189713605 24637.77368407024 19691.550324026968 0.5662740629192625 0.5881724455520095 0.7957957426400855 1.35661362412278 1.4522563949551965 0.9854059797642394 0.7171880328083338 0.9906583721806346 1.2511850656069499 1.0 14.265289079246873 -5.54963606296174 5.607635338278689 1.100503900310811 0.6008987832720446 0.5418172606480954 0.1991624094677149 0.145089026108712 13.32215643031772 0.061648458294957194 0.11220077045004226 2.820745714748027e-06 5.54963606296174 -0.4996051170387664 DLHILPPPLIPT(ph)PPPDDPR ddPTM_A459_Selumetinib_30min_R1 2 DLHILPPPLIPTPPPDDPR 19 0 Q9NRS6;E9PK26;E9PMW6;Q9NRS6-2 Q9NRS6 SNX15 Sorting nexin-15 1 DLHILPPPLIPT(1)PPPDDPR;DLHILPPPLIPT(1)PPPDDPR 84.15899999999998 0.0055773 4415600.0 1874.5 2663.8999999999996 2501.8 2640.6000000000004 2325.1000000000004 2253.49 2167.55 1888.1599999999999 1234.85 1834.0300000000002 True False 1918.1722028579359 2352.0093495864885 2162.0693014037165 2179.468780200999 2114.7951155297474 2230.8219366052112 2004.0499583954827 1838.079863191945 2095.450260124395 2069.4456154650284 0.9269014795669808 1.1365407875470865 1.0447577289523864 1.0531655260296595 1.0219138399800511 1.0779804600489198 0.9683994319150782 0.8881991628366166 1.0125659956777955 1.0 11.015028620048433 -7.342343352872656 6.332902750423417 0.9568082531354658 1.0471557602429782 0.28525068397793685 0.058164404803199225 0.26638986187770897 17.06968885645001 0.023259304031597868 0.015582097562074789 4.546284891078762e-08 7.342343352872656 0.09034750710751238 DLHILPPPLIPT(ph)PPPDDPR ddPTM_A459_Selumetinib_30min_R2 5 DLHILPPPLIPTPPPDDPR 19 0 Q9NRS6;E9PK26;E9PMW6;Q9NRS6-2 Q9NRS6 SNX15 Sorting nexin-15 1 DLHILPPPLIPT(1)PPPDDPR;DLHILPPPLIPT(1)PPPDDPR;DLHILPPPLIPT(1)PPPDDPR;DLHILPPPLIPT(1)PPPDDPR;DLHILPPPLIPT(1)PPPDDPR 83.82600000000002 0.0058454 6483700.0 31844.0 30485.299999999996 33450.6 36484.8 39942.299999999996 26303.999999999996 28561.8 29781.0 23671.6 29515.199999999997 True False 30074.23796163208 32823.4244843107 31298.424814259513 31515.50730020946 34924.391185307424 29927.137236062048 29889.980294133024 29867.657779490033 28406.58143976608 28663.019486300775 1.0492348154738471 1.145148873795322 1.0919444418344797 1.09951805026236 1.2184477354871568 1.04410274187496 1.0428064045526908 1.0420276130979502 0.9910533484911714 1.0 14.806902976883414 -6.975463165050205 24.999283922482455 1.0254713169029377 1.1206022113790688 0.5567174067516749 0.04352401724266175 177.40448972543695 180747.56794087638 0.015116045222554003 0.013330650250278572 1.0581246576748104e-07 6.975463165050205 0.0951308944761311 DLHQGIEAAS(ph)DEEDLR ddPTM_A459_Selumetinib_30min_R2 4 DLHQGIEAASDEEDLR 16 0 A0A0C4DGG1;Q9UKS6;E9PIY1 A0A0C4DGG1 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 1 DLHQGIEAAS(1)DEEDLR;DLHQGIEAAS(1)DEEDLR;DLHQGIEAAS(1)DEEDLR;DLHQGIEAAS(1)DEEDLR 197.67 1.0996e-20 8396200.0 95981.0 106861.1 108803.0 140151.0 120502.0 87829.0 107951.0 111474.5 91294.0 92853.8 True False 90646.76026238562 115057.00275740695 101802.73343574956 121062.19202603973 105363.46145845173 99926.64751771951 112970.93540084852 111798.87233940308 109555.35096748866 90172.86953085464 1.005255358224669 1.2759603121872223 1.1289729822883756 1.3425567208395828 1.1684607799067466 1.1081675457109346 1.2528262213302752 1.2398282645441223 1.2149480385561189 1.0 16.460405812133075 -11.360238553346132 14.34516324035495 0.9990810588713792 1.1978735734579824 0.2867209910533851 0.09102946282063935 0.0025488777549491303 2.889816908013691e-05 0.0839728543231467 0.0202909297790496 4.362761245703528e-12 11.360238553346132 0.1987925145866032 DLIDFDDR ddPTM_A459_Selumetinib_30min_R2 2 DLIDFDDR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 0 ; 145.63 0.02721 4519400.0 49903.0 40809.0 54619.0 51338.0 53382.0 41081.0 45376.0 48577.0 39611.0 46173.0 False True 47129.59103753689 43938.91907838324 51104.873004670764 44345.67583701031 46675.675918864974 46739.534853811754 47486.07391083824 48718.35102764472 47534.306823813095 44839.865518138664 1.0510645046085605 0.9799074678448584 1.1397195868930021 0.9889787876163804 1.0409414787380147 1.042365634100857 1.0590146371342066 1.0864963680129043 1.060090307465005 1.0 15.452494330828262 -7.220942012468364 4.926117868970163 1.0586539396818544 1.0397654565378185 0.003700527993862668 0.04527927486667548 0.8436170542294503 50.55327731045084 0.01736805205259289 0.012975045335194259 6.012540122967768e-08 7.220942012468364 -0.018888483144035906 DLIDNS(ph)FNR ddPTM_A459_Selumetinib_30min_R1 2 DLIDNSFNR 9 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 DLIDNS(1)FNR;DLIDNS(1)FNR 112.64 0.0095742 15091000.0 4233.200000000001 4605.7 4627.3 4307.6 5088.9 3897.4 4814.9 4549.7 2456.9 3613.3999999999996 True False 4331.82532362668 4066.4625028681608 3998.9380759394903 3555.3585236665235 4628.60989351827 3858.1956945560646 4451.708216501771 4429.027176491608 4169.179855123803 4077.2150874965696 1.0624470945648448 0.9973627624744685 0.9808013534048944 0.8720066141640644 1.1352380961486777 0.9462821096654521 1.0918502264336372 1.0862873509111468 1.0225557802700322 1.0 11.99336835075508 -6.272400921960288 24.997956609942264 1.0485530111076267 0.979715536839419 0.20878318144309527 0.06562298109559786 1197.9568825058554 2731954.2465743455 0.02006544040277658 0.022983157009140706 5.340711003172832e-07 6.272400921960288 -0.06883747426820763 DLIDNS(ph)FNR ddPTM_A459_Selumetinib_30min_R2 2 DLIDNSFNR 9 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 DLIDNS(1)FNR;DLIDNS(1)FNR 112.64 0.0095742 15451900.0 50023.0 50677.0 61347.0 62338.0 65086.0 62884.0 50198.0 52013.0 49703.0 59853.0 True False 47242.92191793496 54563.76294776218 57400.00080956328 53847.45686095186 56909.314803777415 71545.70019588381 52532.30646544998 52164.34921878432 59644.98881785318 58124.88837323006 0.8127830132692885 0.938733208352999 0.9875287921584959 0.926409639106538 0.9790868661691489 1.2308961306983743 0.9037833522901734 0.8974528928783128 1.0261523159384374 1.0 15.826868420015897 -3.8567566337777723 0.9707709524270643 0.9975577128275827 1.5411790840357148e-09 0.28022138526608564 0.08888015223559177 14.377636438074537 2.834373758426527 0.03021545558822075 23.000484802366895 0.0001390731739239053 3.8567566337777723 -0.9975577112864036 DLIHDQDEDEEEEEGQR ddPTM_A459_Selumetinib_30min_R1 2 DLIHDQDEDEEEEEGQR 17 0 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0;R4GNE6 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 0 ; 250.52 2.0761e-30 91068000.0 11545.8 13234.2 13545.3 13541.8 12956.6 10801.0 12454.400000000001 12280.2 6141.1 9509.7 False True 11814.794675784015 11684.733711587336 11705.922659007021 11176.978841068652 11784.67781767352 10692.351746523349 11514.95458090503 11954.48920428869 10420.998171802177 10730.362627322225 1.1010620131048088 1.0889411772380404 1.090915849311632 1.0416217260551128 1.0982553178274461 0.9964576331556502 1.0731188666061513 1.1140806345024656 0.9711692450418844 1.0 13.389411211636371 -1.5228853629946406 0.05791430251111927 0.8962345368314801 1.393631295946801 0.33947548594933885 0.039687886359963974 452.1592482977948 1.9684011314396104 3.5396622641352193 19.177418214198973 0.029999542867973746 1.5228853629946406 0.4973967591153208 DLIHDQDEDEEEEEGQR ddPTM_A459_Selumetinib_30min_R2 2 DLIHDQDEDEEEEEGQR 17 0 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0;R4GNE6 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 0 ; 254.72 5.989100000000001e-31 205406000.0 288253.0 238943.0 309616.0 291138.0 329691.0 233568.0 234639.0 268179.0 212195.0 270838.0 False True 272233.05222818506 257269.15977716047 289695.64364441147 251484.5021589372 288272.2691050637 265739.87188079907 245550.17842835782 268959.3564905764 254639.92922367598 263018.20321836695 1.035035023800872 0.9781420321070575 1.101428114478814 0.956148658464319 1.0960164185508101 1.010347833834803 0.9335862515359571 1.0225883729700522 0.9681456496464048 1.0 18.0048031248444 -7.00495921869855 24.972029904796422 0.9813916596197471 1.0321196882907433 0.21544132526872184 0.04699402871064471 329.20648670742787 1657717.3305149062 0.0157644716464546 0.01354506126793719 9.886459265401541e-08 7.00495921869855 0.05072802867099624 DLISHDEMFSDIYK ddPTM_A459_Selumetinib_30min_R1 1 DLISHDEMFSDIYK 14 0 Q5W0H4;A0A0B4J2C3;P13693 Q5W0H4 TPT1 Translationally-controlled tumor protein 0 123.95 0.0021831 25954000.0 6051.1 6615.9 7598.2 7799.4 6696.9 5952.9 6495.5 6168.1 3509.8 5293.2 False True 6192.078856609045 5841.3073523515295 6566.406173925062 6437.3812028704315 6091.166577433729 5893.019230800743 6005.539205442951 6004.5019511875225 5955.874254350407 5972.633780134183 1.036741759925875 0.9780119738431873 1.0994155033857673 1.0778128108711542 1.0198459844790422 0.9866701103291734 1.0055093659715444 1.0053356981570405 0.9971939471930255 1.0 12.544151548416881 -6.50868165378212 9.382386346790238 1.0000542945411315 1.0469628481193731 0.3773588999378652 0.029676177951803946 0.3023013831791611 182.7011172821821 0.010117015290871625 0.010906453545039854 3.0996905995576285e-07 6.50868165378212 0.04690855357824164 DLISHDEMFSDIYK ddPTM_A459_Selumetinib_30min_R2 3 DLISHDEMFSDIYK 14 0 Q5W0H4;A0A0B4J2C3;P13693 Q5W0H4 TPT1 Translationally-controlled tumor protein 0 ;; 113.76 0.0044871 4256900.0 64006.0 59457.0 72569.0 78725.0 86080.0 59347.0 57557.0 61980.0 46184.0 71589.0 False True 60448.802756319004 64017.16071561254 67899.98954715295 68002.5191918 75265.86083503606 67521.51055157288 60233.514547031795 62160.35153865862 55422.09048877793 69522.03955944019 0.8694912165894713 0.9208182199671937 0.9766685496776828 0.9781433286872859 1.0826187107282 0.9712245351180053 0.8663945265232493 0.894110010761588 0.7971873500833209 1.0 16.08518278648784 -10.95735840765079 6.8557118127879395 1.000008744489222 0.9341160948785647 0.07101523512366903 0.07514556479698929 1.1002420720785454e-05 9.075597840146002e-07 0.0797048143666606 0.01932869205197392 1.1031678393070773e-11 10.95735840765079 -0.06589264961065733 DLISLDS(ph)SPAK ddPTM_A459_Selumetinib_30min_R1 1 DLISLDSSPAK 11 0 Q9UN79 Q9UN79 SOX13 Transcription factor SOX-13 1 DLISLDS(0.618)S(0.382)PAK 120.86 0.0046096 3369200.0 1889.1 2715.5 2004.0 1812.5 1681.2 2037.5 2030.1 1902.9 1245.6 2042.0 True False 1933.1123544512811 2397.5679975983 1731.8678071840457 1495.9808998387914 1529.1357568399674 2017.0045999019826 1876.9679225571122 1852.4289105096777 2113.6922249754584 2304.1105907643764 0.8389841886061473 1.0405611636908971 0.7516426573125154 0.6492661011303749 0.6636555393518176 0.8753940058202033 0.8146171152029807 0.8039670135343392 0.9173571066631191 1.0 11.16999424836867 -8.454407515210606 2.3332864303982035 0.9997587308300789 0.8025035190081838 0.2739198525054569 0.10439244549145586 0.41861968327922155 4.9352992670614135 0.11043463396272307 0.030429112999951737 3.5123071257216685e-09 8.454407515210606 -0.1972552118218951 DLISLDSS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 DLISLDSSPAK 11 0 Q9UN79 Q9UN79 SOX13 Transcription factor SOX-13 1 DLISLDS(0.274)S(0.726)PAK 160.22 0.00035018 0.0 29025.0 27119.0 24751.0 27614.0 26412.0 21056.0 29564.0 31213.0 22835.0 25672.0 True False 27411.90669628097 29198.940098671243 23158.54760685123 23852.925563192992 23093.888433724158 23956.272872662797 30938.78457995465 31303.824662409697 27402.638063208993 24930.782656133553 1.0995205034021265 1.171200298899867 0.9289137820610572 0.9567660146170588 0.9263202343967538 0.960911384254878 1.2409872969769358 1.2556294398847614 1.0991487287490875 1.0 14.60564055385094 -7.255810142267677 24.95851589222458 1.1702438207760488 1.005186223971706 0.3184836270783433 0.09956634081465211 508.6737284723988 2255327.671841502 0.04104565540132821 0.0308733919552903 5.5486822812803534e-08 7.255810142267677 -0.16505759680434284 DLKIES(ph)DVQEPTEPEDDLDIMLGNK ddPTM_A459_Selumetinib_30min_R1 2 DLKIESDVQEPTEPEDDLDIMLGNK 25 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 DLKIES(0.995)DVQEPT(0.005)EPEDDLDIMLGNK;DLKIES(1)DVQEPTEPEDDLDIMLGNK 117.04 4.2891e-08 5580200.0 1412.33 2016.03 2071.01 3039.6 1505.94 1843.52 1313.41 1081.1200000000001 1173.94 1497.26 True False 1445.2345410842083 1779.9922703730801 1789.7782172436284 2508.7909203586155 1369.7279928953014 1824.9758625822335 1214.3384262675424 1052.4451856273174 1992.09043881478 1689.4479055474394 0.8554478278606066 1.0535940555067316 1.0593864488906384 1.4849767856829421 0.8107547965212116 1.0802202640222152 0.7187782602116133 0.6229521384894605 1.1791369430650034 1.0 10.722336150069344 DLLEEEEAWEASHKNDLQDTEIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 DLLEEEEAWEASHKNDLQDTEISPR 25 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 DLLEEEEAWEAS(0.286)HKNDLQDT(0.088)EIS(0.626)PR 45.445 0.027906 8409000.0 1155.8 1089.3 865.46 790.68 1070.1 1192.4 1232.2 1075.6 637.14 979.94 True False 1182.727891204695 961.7642495981692 747.935285631489 652.6025809018125 973.3096439414993 1180.4055386125767 1139.2541619500887 1047.071593958805 1081.1800451355687 1105.7248444239187 1.0696403333696411 0.8698043228821969 0.6764208016155795 0.5902034165125571 0.880245794285822 1.0675400345440973 1.0303233826166207 0.9469549311830177 0.9778020730816283 1.0 10.110776705521593 -6.539888877613275 8.341563132067735 1.0000535290270856 0.7897223145528536 0.3861018689309583 0.1209173198081509 0.1999917838119708 76.59909327300771 0.043227628068083924 0.04389175446680291 2.8847695310807686e-07 6.539888877613275 -0.21033121447423198 DLLHNEDR ddPTM_A459_Selumetinib_30min_R2 2 DLLHNEDR 8 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 ; 125.16 0.007249899999999998 7925100.0 104314.0 67654.0 105421.0 102383.0 107887.0 95698.0 107973.0 110716.0 110805.0 87163.0 False True 98516.64548202763 72842.8442581034 98638.32763370604 88438.25877947357 94333.27053798261 108879.53084004972 112993.95844444055 111038.16522997963 132969.0961503774 84646.3777133284 1.1638613268919034 0.8605547718155172 1.1652988621410845 1.0447967316331848 1.1144395435025085 1.2862869479045123 1.3348941974471347 1.3117887407542967 1.5708775702216504 1.0 16.36916071149988 -6.730001423702221 2.338570035298407 1.3311261363486637 1.0513680907986092 0.3664707728630002 0.15157774889802328 0.284838830812781 3.1954602601582995 0.054842360906925146 0.051665871368394026 1.8620810323871786e-07 6.730001423702221 -0.27975804555005457 DLLHNEDRHDDYFQER ddPTM_A459_Selumetinib_30min_R1 4 DLLHNEDRHDDYFQER 16 1 Q8N684-2;Q8N684;Q8N684-3 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 ;;; 150.9 0.00017249 53797100.0 9906.900000000001 10483.0 14256.7 14488.599999999999 13386.9 10484.699999999999 10397.0 9485.8 5717.59 7359.5 False True 10137.711494528296 9255.64548658552 12320.718446447509 11958.437994705817 12176.057258649158 10379.233437345914 9612.745919327277 9234.20576977913 9702.332633748747 8304.1635126006 1.220798636629144 1.114578906417384 1.4836796539172494 1.4400532909257242 1.4662593336671912 1.2498830763142654 1.1575814836426397 1.1119971031118665 1.1683696520458187 1.0 13.019619135932004 -7.180131348799737 2.7600164055585417 1.112758353601712 1.3454943551977567 0.484780908272765 0.1140993905484711 0.28256827337661716 4.204657257725756 0.05493043150428471 0.039391442092391864 6.604936569138017e-08 7.180131348799737 0.23273600159604468 DLLHNEDRHDDYFQER ddPTM_A459_Selumetinib_30min_R2 2 DLLHNEDRHDDYFQER 16 1 Q8N684-2;Q8N684;Q8N684-3 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 ; 83.633 0.0075685000000000014 12088100.0 49278.0 49896.0 54778.0 52112.0 55484.0 35346.0 28969.0 28363.0 24706.4 50495.0 False True 46539.32603546371 53722.862759072996 51253.64311777688 45014.255701785856 48513.6038867466 40214.590660958376 30316.115900984514 28445.531634252584 29648.370354493833 49037.078148234046 0.9490640101920451 1.0955559504722998 1.0452018157126408 0.9179636593704134 0.9893249295990875 0.8200853757924524 0.6182284313380584 0.580082107426235 0.6046112752654197 1.0 15.58158539881805 -6.934100796904673 2.5815902346980515 0.6664802298411079 1.0063456160579636 0.5696690117398104 0.12113517247332961 0.1810863515003845 2.447599673775064 0.04689209440219058 0.03912342503638767 1.1638558747357294e-07 6.934100796904673 0.3398653862168557 DLLHPS(ph)PEEEK ddPTM_A459_Selumetinib_30min_R1 4 DLLHPSPEEEK 11 0 P42677 P42677 RPS27 40S ribosomal protein S27 1 DLLHPS(1)PEEEK;DLLHPS(1)PEEEK;DLLHPS(1)PEEEK;DLLHPS(1)PEEEK 154.23 0.00054657 85175000.0 28536.5 36858.9 25879.1 25781.2 22085.300000000003 26023.6 29482.5 28164.800000000003 16089.099999999999 28906.300000000003 True False 29201.344927636943 32543.442852762262 22364.860363720876 21278.997393061414 20087.688514476406 25761.82621153826 27258.611288503085 27417.77801183614 27302.02759862929 32616.70517620584 0.895288005636436 0.9977538404615736 0.6856872956020166 0.6523956751028495 0.6158711741715268 0.7898353335312277 0.8357254707746652 0.840605384992646 0.8370565773316169 1.0 14.993323433026976 -8.690004900699053 0.8798987578994325 0.9972667775271581 0.7738717987604671 0.26603335772035785 0.10805842508281203 1.2637208413436662 2.0364881491004483 0.11868876146654034 0.040826271572062735 2.041714905263839e-09 8.690004900699053 -0.223394978766691 DLLHPS(ph)PEEEK ddPTM_A459_Selumetinib_30min_R2 6 DLLHPSPEEEK 11 0 P42677 P42677 RPS27 40S ribosomal protein S27 1 DLLHPS(1)PEEEK;DLLHPS(1)PEEEK;DLLHPS(1)PEEEK;DLLHPS(1)PEEEK;DLLHPS(1)PEEEK;DLLHPS(1)PEEEK 134.04 0.0017047999999999998 129912100.0 709309.0 567990.0 579732.0 601492.0 572438.0 548275.0 726071.0 652458.0 485263.0 545311.0 True False 669888.4453689014 611553.0066242948 542432.6742844774 519567.7519684246 500523.22077935 623794.904505091 759834.740182392 654356.5447597639 582329.1593810808 529566.4545418674 1.2649752257220064 1.15481825062608 1.0242957604890979 0.9811190786582342 0.9451565832514016 1.1779350809611637 1.434824154108726 1.2356457610704468 1.099633774735333 1.0 19.014452211765324 -6.985517917213699 24.572626646631377 1.225622579825424 1.0697209303880593 0.1380715856015311 0.13469977539243147 303.412178658522 514815.1336670013 0.04942803612874585 0.04357284532737411 1.0339084452695669e-07 6.985517917213699 -0.15590164943736484 DLLHPSPEEEK ddPTM_A459_Selumetinib_30min_R2 1 DLLHPSPEEEK 11 0 P42677 P42677 RPS27 40S ribosomal protein S27 0 88.338 0.043256 10862000.0 81473.0 72485.0 99287.0 122110.0 115500.0 86783.0 87165.0 87858.0 74348.0 105310.0 False True 76945.05682226009 78044.36642399007 92898.98251551177 105478.40734850056 100989.85741689912 98736.57051236204 91218.34521417071 88113.65223432519 89219.67745668768 102269.4266717603 0.752375947791511 0.7631250996886686 0.9083749223868878 1.0313777125889214 0.9874882523887805 0.9654554027105562 0.8919414939808092 0.8615835162265171 0.872398334089067 1.0 16.64201539194044 -5.2955058600569584 4.072243042936641 0.9408082506426585 0.7539904863462338 0.6578622907556883 0.05296163997415346 0.13701219952782212 5.134137510211425 0.015910061767721466 0.038677185116976806 5.06400516473893e-06 5.2955058600569584 -0.18681776429642472 DLLHSEGS(ph)ENEGPVSSSSSDCR ddPTM_A459_Selumetinib_30min_R1 2 DLLHSEGSENEGPVSSSSSDCR 22 0 Q9NY27-2;Q9NY27-3;Q9NY27 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 DLLHSEGS(1)ENEGPVSSSSSDCR;DLLHSEGS(1)ENEGPVSSSSSDCR 192.51 4.7327e-22 11013500.0 2852.7 3312.6 1961.87 2149.7 2914.7 2733.1 3655.1 3256.0 1496.79 2669.9 True False 2919.162359612075 2924.7592520140397 1695.4588297805212 1774.2952498667307 2651.0658996320803 2705.6074954562505 3379.392864262109 3169.6403030214474 2539.9433087837333 3012.6076720283077 0.968981917797043 0.9708397409892002 0.5627877952787044 0.5889566259625654 0.879990422996961 0.8980948699618221 1.1217500690977311 1.0521251513933156 0.8431045742752351 1.0 11.556797089531765 -6.782231417233918 2.5899213680943847 1.0058037878993593 0.7723827074357391 0.32113508715006833 0.14387189773831213 0.34938380336492675 4.802252106178419 0.05977733768706861 0.05469089411160192 1.6510817718641102e-07 6.782231417233918 -0.2334210804636202 DLLHSEGS(ph)ENEGPVSSSSSDCR ddPTM_A459_Selumetinib_30min_R2 2 DLLHSEGSENEGPVSSSSSDCR 22 0 Q9NY27-2;Q9NY27-3;Q9NY27 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 DLLHSEGS(1)ENEGPVSSSSSDCR;DLLHS(0.002)EGS(0.998)ENEGPVSSSSSDCR 131.65 1.4985999999999997e-05 25707000.0 57983.0 35966.0 62638.0 76305.0 75727.0 59421.0 64823.0 71583.0 71657.0 57727.0 True False 54760.53698433971 38724.476551082626 58607.93927509786 65912.12736653314 66213.49725203041 67605.70337986787 67837.39794433773 71791.29467879639 85990.40226386538 56060.27151724143 0.9768154078151051 0.6907650552347547 1.0454451555246729 1.1757368557564292 1.1811126749835013 1.2059467703269262 1.2100797250593804 1.2806091147224796 1.533892004740271 1.0 15.774691111355267 -5.603916710334652 2.3895201147087506 1.2405671950594288 0.8324421658185396 0.5506405250011827 0.14111301299762394 0.20407123992326506 2.338844186344697 0.040082209130135556 0.08622867594612973 2.489334680949497e-06 5.603916710334652 -0.4081250292408892 DLLPSGSRDEPPPASQSTSQDCSQALKQS(ph)P ddPTM_A459_Selumetinib_30min_R2 1 DLLPSGSRDEPPPASQSTSQDCSQALKQSP 30 2 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 DLLPSGSRDEPPPAS(0.001)QS(0.001)T(0.003)S(0.037)QDCS(0.166)QALKQS(0.793)P 55.986 0.0056084 4558000.0 6656.1 5460.5 8670.2 7834.8 5919.4 3736.1 4095.4 4776.7 2791.9 7665.6 True False 6286.1806084794425 5879.302791725147 8112.368771399998 6767.686724216139 5175.752051892575 4250.7138620609585 4285.8442148811455 4790.599406174746 3350.358012203775 7444.274210379306 0.8444316303817541 0.7897751514214547 1.0897460977578162 0.9091130354629033 0.6952661744614665 0.5710044716158263 0.5757235821466026 0.6435280687935127 0.45005838279472316 1.0 12.86191548281416 -6.34901691957976 3.657616370672288 0.6226175946391981 0.9137830075735432 0.396573655975207 0.15142347496429487 0.22097176343198383 5.578450969765264 0.04682427268774403 0.054329099585504054 4.4769586215552567e-07 6.34901691957976 0.29116541293434517 DLLS(ph)LGSPR ddPTM_A459_Selumetinib_30min_R2 1 DLLSLGSPR 9 0 B1ALC3;A0A1W2PPS5;Q96FN5 B1ALC3 KIF12 Kinesin-like protein;Kinesin-like protein KIF12 1 DLLS(0.989)LGS(0.011)PR 81.297 0.044232 1479900.0 11108.0 13113.0 14266.0 11462.0 13481.0 11040.0 10502.0 12123.0 8253.3 14410.0 True False 10490.661828847167 14118.724935059403 13348.141091646374 9900.855826947138 11787.396258330884 12560.659788858158 10990.363809318213 12158.275922929317 9904.190616469583 13993.94585832365 0.7496571685395855 1.008916647098612 0.9538511315382038 0.7075099423125232 0.8423211278411298 0.8975781324312493 0.7853656088558542 0.8688239933197633 0.7077482446152623 1.0 13.772515194631243 -5.711639650486311 24.99998477273369 0.8259209961907767 0.9146191789260972 0.09600375982795617 0.1023827867615202 218.58537383440952 109730.20077658465 0.026359249054631478 0.04565547360001122 1.9424969676454685e-06 5.711639650486311 0.08869818273532049 DLLSDLQDIS(ph)DSER ddPTM_A459_Selumetinib_30min_R1 6 DLLSDLQDISDSER 14 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;Q9UQ88-9;E7ESP2;J3KS35;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 DLLSDLQDIS(0.999)DS(0.001)ER;DLLSDLQDIS(1)DSER;DLLSDLQDIS(0.999)DS(0.001)ER;DLLSDLQDIS(0.997)DS(0.003)ER;DLLSDLQDIS(0.971)DS(0.029)ER;DLLSDLQDIS(1)DSER 279.19 1.6089e-54 72544700.0 12204.08 14320.939999999999 13735.12 13632.550000000001 15407.67 12613.499999999998 15493.92 14153.590000000002 8043.07 13202.230000000001 True False 12488.411318994113 12644.237687175624 11869.966145613638 11251.88105715714 14014.04896894507 12486.619642141675 14325.201140173438 13778.190815860358 13648.50234740957 14896.864821110274 0.8383248065255212 0.8487851530516366 0.7968096836585888 0.7553187326511921 0.940738144383631 0.8382045344498896 0.9616252353900175 0.9249054066957332 0.9161996508197043 1.0 13.86272111406458 -6.8555112338971345 1.088303094456573 0.9481151597318539 0.8161366337583128 0.5832878701775812 0.04785615430369193 0.37396616650152653 0.9341529828575893 0.026987978262646813 0.02224150059382312 1.3947255798011223e-07 6.8555112338971345 -0.1319785259735411 DLLSDLQDIS(ph)DSER ddPTM_A459_Selumetinib_30min_R2 6 DLLSDLQDISDSER 14 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;Q9UQ88-9;E7ESP2;J3KS35;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 DLLSDLQDIS(0.961)DS(0.039)ER;DLLSDLQDIS(0.65)DS(0.35)ER;DLLSDLQDIS(0.933)DS(0.067)ER;DLLSDLQDIS(0.957)DS(0.043)ER;DLLSDLQDIS(0.986)DS(0.013)ER;DLLSDLQDIS(0.924)DS(0.076)ER 138.81 0.00063967 4422930.0 56176.9 50634.1 59343.1 58584.700000000004 59271.40000000001 45804.8 49280.0 63951.1 44718.7 54104.0 True False 53054.81279194851 54517.57265570743 55525.029553881934 50605.36279575552 51825.196838960954 52113.9954254248 51571.61764646747 64137.18711332548 53663.689544875175 52541.87694092595 1.0097624196333768 1.0376023056238133 1.056776666282973 0.9631434151591559 0.986359830601964 0.9918563717093277 0.9815336004164952 1.220687018574468 1.0213508285060031 1.0 15.681180117992051 DLLSDLQDISDS(ph)ER ddPTM_A459_Selumetinib_30min_R1 1 DLLSDLQDISDSER 14 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;Q9UQ88-9;E7ESP2;J3KS35;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 DLLSDLQDIS(0.198)DS(0.802)ER 130.27 0.00098507 1701700.0 425.18 642.35 913.08 500.82 765.29 578.84 776.15 776.23 355.32 535.71 True False 435.0858667437381 567.143363379587 789.0887511894257 413.3611885557315 696.0696546229236 573.0173951446691 717.6043806180501 755.6418588496123 602.9520884539825 604.4735967572886 0.719776461830203 0.9382434012371086 1.3054147533035503 0.6838366320269674 1.1515302874385316 0.9479609998164237 1.1871558732550997 1.250082489794871 0.9974829201614953 1.0 9.239535514097376 -6.7570707018320615 1.5910625619012195 1.1187257572604807 0.9465255114710354 0.12982150138630844 0.18552071645369522 0.7862607237204153 4.131524061124315 0.08036936734416568 0.0733010270397838 1.7495618420470314e-07 6.7570707018320615 -0.17220024578944537 DLLSDLQDISDS(ph)ER ddPTM_A459_Selumetinib_30min_R2 2 DLLSDLQDISDSER 14 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;Q9UQ88-9;E7ESP2;J3KS35;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 DLLSDLQDIS(0.03)DS(0.97)ER;DLLSDLQDIS(0.048)DS(0.952)ER 128.85 0.0011012 1659300.0 15491.1 12564.0 14993.7 17615.9 18150.6 12270.3 12920.2 17386.1 12518.8 15016.8 True False 14630.16667778667 13527.618400372641 14029.021665906224 15216.584030877511 15870.359359577214 13960.422446306722 13521.01490089061 17436.69067257619 15022.909804497518 14583.225965667905 1.003218815386203 0.9276149483125068 0.9619971396543948 1.043430587080024 1.0882612253927562 0.9572931585351966 0.9271621335856709 1.195667591904971 1.0301499709230815 1.0 13.832022274102265 -5.757797579841308 23.58330273701854 1.0372615959123859 0.9606107173409861 0.16893084933498437 0.07112904943091106 79.94384893145009 517671.9740065559 0.02031134396522226 0.033450138294589725 1.7466360521994081e-06 5.757797579841308 -0.07665087857139974 DLLVSSGSNNSLPCGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DLLVSSGSNNSLPCGSPK 18 0 Q5THK1-2;Q5THK1-4;Q5THK1;Q5THK1-3 Q5THK1-2 PRR14L Protein PRR14L 1 DLLVSSGSNNSLPCGS(1)PK 120.9 0.00094325 13205000.0 3266.4 3705.1 4345.1 4359.5 3202.0 3375.6 3498.3 3204.7 2191.2 3370.6 True False 3342.5007646920026 3271.305169545739 3755.05928592585 3598.1951629501827 2912.379665359015 3341.644528799575 3234.4204145025133 3119.700945667329 3718.3063610839977 3803.249342424293 0.8788539650575219 0.8601342891340701 0.9873292408254976 0.9460844764536518 0.7657609068309431 0.8786288323314403 0.8504360675024286 0.8202725261443805 0.9776656817125352 1.0 11.893016810348156 -8.390199039553535 5.783212237784286 0.9982148386386395 0.8752575452039716 0.3899760422849624 0.05791672529930131 0.2504874934402281 10.064518929406358 0.05926426869508426 0.015388321560422205 4.071936159559279e-09 8.390199039553535 -0.12295729343466788 DLLVSSGSNNSLPCGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 DLLVSSGSNNSLPCGSPK 18 0 Q5THK1-2;Q5THK1-4;Q5THK1;Q5THK1-3 Q5THK1-2 PRR14L Protein PRR14L 1 DLLVSSGSNNSLPCGS(1)PK;DLLVSSGSNNSLPCGS(1)PK;DLLVSSGSNNSLPCGS(1)PK 195.55 2.8522e-10 13049700.0 113488.0 107339.0 110680.0 101041.0 94081.0 81506.0 98712.0 96074.0 67674.0 99909.0 True False 107180.79128845935 115571.55615071596 103558.9692992727 87279.04149455279 82261.70368518865 92732.71166219862 103302.30359411713 96353.55943409319 81210.69096954717 97024.36757524317 1.1046791024465044 1.191160107908864 1.0673501089194104 0.8995579530767587 0.8478458117379023 0.955767236413921 1.0647047352718415 0.9930861889861867 0.8370133503479693 1.0 16.566059503808212 -5.572847561040606 4.388313376804593 0.9446309465498 1.145389920948404 0.6013037750139865 0.06855540436022445 0.14174423086694077 5.794724605635427 0.02019454508729385 0.0374151934170834 2.6739448084186116e-06 5.572847561040606 0.20075897439860402 DLMPHDLAR ddPTM_A459_Selumetinib_30min_R2 1 DLMPHDLAR 9 0 C9K0M0;C9JEY0;C9JE81;B5MD38;P55084-2;P55084 C9K0M0 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 109.66 0.012873 0.0 27682.0 15478.0 20500.0 24389.0 18501.0 14069.0 30525.0 22782.0 20883.0 18778.0 False True 26143.54525982601 16665.112830385835 19181.052318712373 21067.176126628314 16176.738978961475 16006.877044333814 31944.47298414003 22848.291848236866 25060.183519772007 18235.8303488967 1.433636130608538 0.9138664108812629 1.051833228963597 1.1552627834083198 0.8870854065573273 0.8777706711502863 1.7517421676426557 1.2529339992252795 1.3742277176475375 1.0 14.15448827228416 -7.2324305218651945 24.98206133243216 1.3658040125787105 1.0439278116507573 0.2759401751861913 0.23000562240851596 833.5148807490691 717813.4411472945 0.08460611829008714 0.06552336519185638 5.855574059019282e-08 7.2324305218651945 -0.3218762009279532 DLMVGDEASELR ddPTM_A459_Selumetinib_30min_R1 1 DLMVGDEASELR 12 0 P61160 P61160 ACTR2 Actin-related protein 2 0 136.02 0.019967 3203700.0 1196.4 1357.3 1256.8 1643.4 1815.8 1524.7 1310.7 1337.3 647.12 1171.2 False True 1224.273792210848 1198.3866850083493 1086.1334631082382 1356.4110404386588 1651.561210605528 1509.3629023168348 1211.8328437493753 1301.8304598374013 1098.1153762252077 1321.5349284540837 0.9264029015434266 0.9068142348762649 0.8218726873748123 1.0263906093086566 1.2497295190960296 1.1421286489056102 0.9169888874348281 0.9850897103115297 0.8309393513418297 1.0 10.36799884088755 -5.7815699423956 22.95884181525337 1.0311558336935263 0.8872084470427843 0.23920832661034985 0.11068649249175765 136.579105746452 155767.43388503676 0.03455453652808031 0.05135713743227589 1.6535984540770377e-06 5.7815699423956 -0.14394738665074192 DLMVGDEASELR ddPTM_A459_Selumetinib_30min_R2 1 DLMVGDEASELR 12 0 P61160 P61160 ACTR2 Actin-related protein 2 0 164.97 0.0071354 4037400.0 26400.0 25336.0 35041.0 34969.0 35417.0 30316.0 27093.0 24585.0 26591.0 31744.0 False True 24932.79368757338 27279.189731919858 32786.500209756116 30206.1618751103 30967.599828002712 34491.75381875214 28352.878183761015 24656.538279734163 31909.943014617515 30827.468239182916 0.8087849931147711 0.8848988025960219 1.0635482601222241 0.9798456895891662 1.0045456729606386 1.1188643047537643 0.919727755901907 0.7998236536464821 1.035113969367706 1.0 14.911928789956008 -5.033225952357058 5.033292196399403 0.9852047614264838 0.8229436576518028 0.347921675500253 0.08129136594093628 0.20350495170891708 13.595750418153917 0.022120909358317217 0.07081874754832289 9.263477428474306e-06 5.033225952357058 -0.16226110377468106 DLNES(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 DLNESPVK 8 0 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 DLNES(1)PVK 87.641 0.032187 78194000.0 6679.0 7851.2 5823.1 6057.2 5920.7 6381.7 6897.5 6300.2 4057.3 6604.4 True False 6834.6077049283285 6931.977854076145 5032.355003998712 4999.423727726084 5385.173730384485 6317.505892119987 6377.21602179089 6133.0982300662545 6884.941766532539 7452.139072303747 0.9171336764674045 0.9301997435661383 0.6752900013234744 0.6708709645941386 0.7226346258618223 0.8477439606031131 0.8557564425350216 0.8229983593382235 0.9238879870238567 1.0 12.863438882861493 -8.349253167840008 0.9250095014804156 0.999743890147999 0.7881357277326186 0.37071357800357585 0.08570191173762785 0.6669921190475288 1.23744361392645 0.09168381649378138 0.03236447435844093 4.474523900175673e-09 8.349253167840008 -0.21160816241538039 DLNES(ph)PVK ddPTM_A459_Selumetinib_30min_R2 3 DLNESPVK 8 0 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 DLNES(1)PVK;DLNES(1)PVK;DLNES(1)PVK 100.93 0.017443 284356000.0 1158316.0 962203.0 1074976.0 1108836.0 1023012.0 855127.0 1152561.0 1114039.0 854224.0 1020591.0 True False 1093941.4338263362 1036000.8761297163 1005813.2145053728 957810.6239512101 894492.0867166816 972912.9821799734 1206157.3702562933 1117280.6690509147 1025092.6690127746 991123.8860161273 1.1037383411507609 1.0452788907085817 1.0148208803122383 0.9663883975202923 0.902502804480011 0.9816260065032298 1.216959239176955 1.1272865933459448 1.0342729939979416 1.0 19.918705873493813 -7.212310959607551 24.999748865958324 1.1052371556737937 0.9987298288230072 0.2723719781269759 0.07288996162785527 469.3855545300886 238854.0572262789 0.02934489027352811 0.02273042254712256 6.133227021358445e-08 7.212310959607551 -0.10650732685078645 DLNESPVKS(ph)FVSISEATDCLVDFKK ddPTM_A459_Selumetinib_30min_R1 1 DLNESPVKSFVSISEATDCLVDFKK 25 2 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 DLNES(0.073)PVKS(0.643)FVS(0.257)IS(0.022)EAT(0.004)DCLVDFKK 65.881 0.00083188 10530000.0 1504.5 1108.4 3903.3 3906.1 2157.3 1991.6 1680.2 1496.8 1227.6 1063.2 True False 1539.5519227526086 978.6280127188197 3373.2532992921597 3223.9729615780984 1962.1725959022501 1971.566312228116 1553.4611612632189 1457.1000017083854 2083.147539643443 1199.6720764449974 1.283310625445898 0.8157462626110293 2.811812799117707 2.687378513578257 1.6355907872064337 1.6434210239105356 1.2949048258809264 1.214581909771733 1.7364307968361312 1.0 10.228424391879681 -6.925370503942707 2.350641609158482 1.3357868838517313 1.89588169445825 0.15896134643344872 0.5791504046423458 0.6398672918973104 7.176531619140098 0.26200006690965183 0.2180178888676835 1.1874887285321123e-07 6.925370503942707 0.5600948106065187 DLNESPVKSFVSISEATDCLVDFKK ddPTM_A459_Selumetinib_30min_R1 1 DLNESPVKSFVSISEATDCLVDFKK 25 2 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 0 82.36200000000002 9.6246e-05 2256300.0 649.09 732.67 1878.4 1780.3 1063.7 983.67 537.08 967.0 733.85 573.58 False True 664.2125340907214 646.8886557909577 1623.3235973126316 1469.4040253699307 967.488522811488 973.7751729008999 496.5676231944111 941.3520187413204 1245.2898517166348 647.2045801423266 1.026279100102559 0.9995118632329528 2.508207832762319 2.2703857025344205 1.4948727998784062 1.5045863437597387 0.7672498595192436 1.454489117698005 1.9241054373298525 1.0 9.33807800725405 -6.718949018120008 3.167279233476742 1.313750272901397 1.718729108474827 0.09624685958167634 0.5253225598508241 0.6448613039108472 13.251344961494581 0.2061920088315488 0.19682540993412584 1.910077469623313e-07 6.718949018120008 0.40497883557343006 DLNYCFSGMSDHR ddPTM_A459_Selumetinib_30min_R1 2 DLNYCFSGMSDHR 13 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P55795 P31943;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 0 ; 152.0 0.00063274 11767100.0 6054.1 6559.5 6833.1 7046.4 11021.7 6489.7 9131.2 5735.6 1762.3600000000001 3537.3999999999996 False True 6195.148750772059 5791.51069057118 5905.202551531586 5815.87851730982 10024.789181039187 6424.419510176146 8442.4262324287 5583.473256145522 2990.5962023183624 3991.459747193881 1.55210102146901 1.4509755972467944 1.479459377157223 1.4570805884735683 2.511559633812397 1.6095413500518727 2.115122478277273 1.3988549577810163 0.749248744001701 1.0 11.962700746622346 -8.061971220753303 4.44536277568268 0.9001342215103719 1.7348781642436222 0.5257265168380296 0.3255309723119171 0.18459757261190773 7.168339756132444 0.24122489892514215 0.0882935185133585 8.670193283334863e-09 8.061971220753303 0.8347439427332503 DLNYCFSGMSDHR ddPTM_A459_Selumetinib_30min_R2 1 DLNYCFSGMSDHR 13 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P55795 P31943;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 0 129.17 0.0024624000000000004 11002000.0 24338.0 22497.0 40112.0 56714.0 61044.0 41888.0 27868.0 32570.0 39599.0 49011.0 False True 22985.391392733374 24222.447560743647 37531.237590643446 48989.45536289305 53375.106979715914 47657.69177859515 29163.91721939439 32664.773307746244 47519.90648850508 47595.92508412913 0.4829277160199132 0.5089185159849037 0.7885388827783966 1.0292783526383984 1.12142177897313 1.0012977307270916 0.6127397916490775 0.6862934852092689 0.9984028339508124 1.0 15.53855044231438 -5.345085195549909 3.2710784781693127 0.9071923806534753 0.48633775271138485 0.5556533855064183 0.14963103794106994 0.20769760644309937 4.238153382160372 0.045916984533802975 0.11430556836278315 4.517673124866073e-06 5.345085195549909 -0.42085462794209044 DLPAIQES(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 DLPAIQESPTR 11 0 P49796-1;P49796-4;P49796-6;P49796 P49796-1 RGS3 Regulator of G-protein signaling 3 1 DLPAIQES(0.836)PT(0.164)R 118.73 0.0052246 11446000.0 2128.7 3025.7 2054.4 2110.4 2467.9 2164.6 2892.8 2098.6 1165.5 1742.5 True False 2178.294568270839 2671.4496373902316 1775.4237640114295 1741.8582571143634 2244.6788807431335 2142.8260892995495 2674.59376699336 2042.9383107864892 1977.768375247992 1966.1668483873275 1.1078889719138034 1.3587095314832438 0.9029873357226282 0.8859157901797884 1.141652287843346 1.0898495674754765 1.3603086478581878 1.039046260220556 1.0059005810570858 1.0 10.941170038246653 -9.734536457526138 0.010234175604908602 1.3435003293726087e-05 2.1185186240092273 0.03391516161392871 0.15310691613329397 19623.92510453687 54.07189411117172 5833.0179420193635 5360.520969549105 1.8427377909859064e-10 9.734536457526138 2.1185051890059334 DLPAIQESPT(ph)R ddPTM_A459_Selumetinib_30min_R2 2 DLPAIQESPTR 11 0 P49796-1;P49796-4;P49796-6;P49796 P49796-1 RGS3 Regulator of G-protein signaling 3 1 DLPAIQES(0.031)PT(0.969)R;DLPAIQES(0.034)PT(0.966)R 157.33 0.0012825 18274600.0 32357.0 27103.0 31371.0 37234.0 40734.0 32692.0 32750.0 34720.0 31021.0 32726.0 True False 30558.72747533379 29181.712950119356 29352.62401416224 32162.664967767363 35616.63075341963 37195.02625157163 34272.93989289387 34821.02945179459 37226.06679915949 31781.115347640527 0.9615372884514738 0.9182092142114152 0.9235869695914061 1.012005545304286 1.1206853618516526 1.1703499340633758 1.0784058242763446 1.0956515865129872 1.1713266319309088 1.0 14.955882136025497 -6.041410099974375 2.9454021819169203 1.1124933124781513 0.9334542127581237 0.7266104018717746 0.04734101339993954 0.12678616806841586 2.2001519020776166 0.01404022867412378 0.02021253115950179 9.090544560980845e-07 6.041410099974375 -0.17903909972002763 DLPDGHAAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 DLPDGHAASPR 11 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 DLPDGHAAS(1)PR;DLPDGHAAS(1)PR 169.09 0.00044143 37389000.0 5364.5 6039.9 7661.8 7032.700000000001 6509.5 5809.299999999999 6736.8 5819.7 3420.6000000000004 5055.200000000001 True False 5489.482412500075 5332.745700126667 6621.369643254854 5804.570965128971 5920.716874345571 5750.863716422372 6228.637752171201 5665.342650950221 5804.508369260644 5704.084161817865 0.9623775275346924 0.9348995472091958 1.1608120524548247 1.0176166410698753 1.0379785266805508 1.0082010631816483 1.0919610537769773 0.9932081102296889 1.0176056672015819 1.0 12.477779553074587 DLPDGHAAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 DLPDGHAASPR 11 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 DLPDGHAAS(1)PR;DLPDGHAAS(1)PR 112.02 0.0039324 21070000.0 243770.0 198228.0 254480.0 246850.0 238200.0 186079.0 199313.0 225568.0 202061.0 239730.0 True False 230222.23928862743 213431.45019651926 238107.03385687433 213228.60415999836 208275.1864649815 211709.6931930194 208581.4494312172 226224.36553520718 242478.8460560575 232808.37200665672 0.9888915819661531 0.9167687929642693 1.0227597564664304 0.9158974925261772 0.8946206902689318 0.9093731955093348 0.8959362055298131 0.9717192023005887 1.041538343170598 1.0 17.828783414277986 -8.02324192460403 5.477666216557376 1.0177255446675288 0.9341252140298125 0.42222415124910695 0.04003034829989678 0.18103708827439755 16.52411949832888 0.02723324023368357 0.010821785585634116 9.47890292034619e-09 8.02324192460403 -0.08360033063771632 DLPEHAVLK ddPTM_A459_Selumetinib_30min_R1 2 DLPEHAVLK 9 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;Q5RI18;A0A1W2PRZ7;A0A1W2PQ74;A0A1W2PQL0;A0A1W2PP34;A0A1W2PPL4;A0A1W2PPH7;A0A1W2PQD4 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 ; 120.99 0.0089986 20196800.0 10135.0 12385.3 11876.4 13308.0 11737.1 11617.3 11247.6 10285.8 7409.799999999999 9458.400000000001 False True 10371.125780722954 10935.223318230237 10263.650112395506 10984.0076220991 10675.481377353311 11500.440509664437 10399.184476505294 10012.987171012892 12573.88940962039 10672.477772617913 0.9717636336832549 1.0246189826964498 0.9616932760196207 1.029190020922833 1.0002814346208437 1.0775792421110313 0.9743927041184569 0.9382064206966954 1.1781602808188438 1.0 13.381607537462497 -5.758763804604908 0.4207140474461734 1.0342391640888742 0.973164054164273 0.07323293422546062 0.0635130705824117 8.656125895374636 2.1640984622363844 0.055598514397548524 0.24635038132789966 1.7427544301161555e-06 5.758763804604908 -0.06107510992460119 DLPEHAVLK ddPTM_A459_Selumetinib_30min_R2 1 DLPEHAVLK 9 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;Q5RI18;A0A1W2PRZ7;A0A1W2PQ74;A0A1W2PQL0;A0A1W2PP34;A0A1W2PPL4;A0A1W2PPH7;A0A1W2PQD4 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 123.86 0.007717799999999999 13398000.0 125970.0 120390.0 130080.0 134410.0 139620.0 100680.0 113070.0 118730.0 101270.0 114540.0 False True 118969.0916978643 129623.52588513706 121710.79442039541 116103.12612981703 122079.68738136334 114547.75611795657 118327.97904395458 119075.48464319046 121526.82972021803 111232.93258934017 1.0695491787228626 1.1653340684965392 1.0941974789942683 1.0437837376674863 1.097513879563602 1.0298007384274797 1.063785484113851 1.0705056665439554 1.092543609983581 1.0 16.76322446258159 -5.543547243453868 6.6782184759026055 1.0610794441929439 1.1205413502185104 0.33550211278609265 0.034688900437779904 0.15802031635513505 27.81342613901636 0.008774865739623853 0.01577181376990274 2.8605711648410696e-06 5.543547243453868 0.05946190602556656 DLPPFGINS(ph)PQALK ddPTM_A459_Selumetinib_30min_R2 1 DLPPFGINSPQALK 14 0 A0A2R8Y661;A0A2R8YGD3;Q9Y4G8;H0Y8H7 A0A2R8Y661 RAPGEF2 Rap guanine nucleotide exchange factor 2 1 DLPPFGINS(1)PQALK 118.21 0.0023919 4305000.0 16834.0 13208.0 15690.0 17663.0 14700.0 12437.0 16679.0 15903.0 12633.0 12544.0 True False 15898.433671841294 14221.01112958626 14680.522481980346 15257.268929625478 12853.254580332608 14150.083858154787 17454.606548811502 15949.275097116633 15159.95299551212 12181.82212677389 1.305094878778342 1.1673960579616842 1.2051171269127854 1.252461969223159 1.0551175716219832 1.1615736718938738 1.4328403720859453 1.3092684272628168 1.2444733503531238 1.0 13.57244232368434 DLPS(ph)PDSR ddPTM_A459_Selumetinib_30min_R1 2 DLPSPDSR 8 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 DLPS(0.997)PDS(0.003)R;DLPS(1)PDSR 154.01 0.00077829 28289000.0 9541.6 11661.9 11862.1 12604.0 12014.3 9632.2 11447.900000000001 10289.0 5733.6 9471.9 True False 9763.900715278347 10296.519326529777 10251.291973851236 10402.948006382408 10927.608686296942 9535.308813337851 10584.375686242833 10016.102296617828 9729.500434424606 10687.710629119047 0.9135633489810486 0.9633980263721348 0.9591663106897025 0.973356069169688 1.0224461594725707 0.8921750545302531 0.9903314239632691 0.93716069270519 0.9103446726856766 1.0 13.383665231884002 -5.614530098602878 0.002099269845344287 1.906955850074016 6.151966120948275e-05 0.03446028845883342 0.03956083903293837 794232.2372237901 350.3976734060603 157355.15259379934 160941.1899101604 2.429237078896092e-06 5.614530098602878 -1.9068943304128065 DLPTIPGVT(ph)SPSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R1 1 DLPTIPGVTSPSSDEPPMEASQSHLR 26 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPT(0.002)IPGVT(0.25)S(0.25)PS(0.25)S(0.25)DEPPMEASQSHLR 59.56100000000001 0.010499 7489500.0 1342.6 1643.9 854.25 1010.1 1562.4 1124.1 1998.8 1230.5 654.11 1368.0 True False 1373.879967755169 1451.4314237716242 738.2475420593667 833.7049969253311 1421.0811958641239 1112.792574601138 1848.0289067568879 1197.8631427726941 1109.9768956958073 1543.596125448416 0.8900514487596655 0.9402922175319546 0.4782647027213191 0.5401056553463032 0.9206301910425556 0.72090915250119 1.1972230794632461 0.7760210867494332 0.7190850491240759 1.0 10.592079612376766 -6.298534007890701 24.776450025879836 0.8847879760267667 0.7117641029825235 0.17784363663195468 0.18609627608533447 1002.2579972556655 669430.8694294096 0.060915520132843466 0.06907334146024979 5.028818856084104e-07 6.298534007890701 -0.17302387304424327 DLPTIPGVT(ph)SPSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R2 3 DLPTIPGVTSPSSDEPPMEASQSHLR 26 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPT(0.003)IPGVT(0.444)S(0.444)PS(0.101)S(0.009)DEPPMEASQSHLR;DLPT(0.001)IPGVT(0.496)S(0.496)PS(0.007)SDEPPMEASQSHLR;DLPT(0.014)IPGVT(0.415)S(0.415)PS(0.116)S(0.04)DEPPMEASQSHLR 108.77 3.4514999999999995e-08 48672000.0 135285.2 102850.1 148000.1 201268.0 238335.0 175096.0 184363.4 224678.0 229098.0 162835.4 True False 127766.59017356466 110738.37195480456 138477.93469632507 173854.9511933346 208393.22655806632 199213.88463676674 192936.6634091465 225331.77578255505 274924.00153295585 158133.91890482118 0.8079644838908075 0.7002822210550325 0.8757003915122928 1.0994159405989028 1.3178274971070285 1.2597795970431307 1.220083994283811 1.4249427152828573 1.7385517505477692 1.0 17.27078732592367 -5.905317186026112 1.325245259365243 1.3571304020387296 0.7309180237107437 0.6474419535166749 0.17677301604747428 0.27243816453589115 0.9696102040392679 0.06298716825597159 0.12960734989245307 1.2436060150795975e-06 5.905317186026112 -0.6262123783279859 DLPTIPGVTS(ph)PSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R1 1 DLPTIPGVTSPSSDEPPMEASQSHLR 26 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPT(0.002)IPGVT(0.119)S(0.828)PS(0.046)S(0.005)DEPPMEASQSHLR 87.704 4.4987e-05 40330000.0 6706.9 5875.8 4660.5 4809.4 5043.0 5025.9 5579.0 4874.2 1939.1 3945.0 True False 6863.157720644378 5187.858604414691 4027.6296982940344 3969.5285736191363 4586.861540413965 4975.344009152084 5158.171538321331 4744.920382367056 3290.511073739493 4451.3791775540985 1.5418047860877762 1.1654497173761922 0.9048049015018078 0.8917525142848592 1.03043604183239 1.1177084248944815 1.1587805335324397 1.0659438778644441 0.7392115886985686 1.0 12.12003668239169 -4.82752865562495 2.941841345411802 1.000374917531808 1.6042476122686329 0.676021575759863 0.11611014102464873 0.21938889321429078 2.907405546982807 0.0316977972278911 0.3018877632465658 1.4875492193466477e-05 4.82752865562495 0.6038726947368249 DLPTIPGVTS(ph)PSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R2 2 DLPTIPGVTSPSSDEPPMEASQSHLR 26 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPT(0.009)IPGVT(0.236)S(0.359)PS(0.359)S(0.036)DEPPMEASQSHLR;DLPTIPGVT(0.138)S(0.502)PS(0.297)S(0.063)DEPPMEASQSHLR 114.64 5.1642e-09 17326300.0 39898.0 32113.0 50999.0 53333.0 60040.0 46466.0 46727.0 52693.0 55714.0 45626.0 True False 37680.62888434859 34575.96384043033 47717.77986351278 46068.953395443365 52497.2384355898 52866.26972364884 48899.89808779397 52846.32790620423 66858.35677922606 44308.65882941532 0.8504123094633919 0.7803432727121112 1.0769402894188762 1.039728003792781 1.1848076611323273 1.1931363106064576 1.1036194590329296 1.1926862446831945 1.5089230535418645 1.0 15.435301038365301 -5.455478983869777 0.8114892873417189 1.2172189808748457 0.7263803181070106 0.5497587003624096 0.12904257801607658 0.8486646735189987 0.8038036441726832 0.05419465969279295 0.3169620859371584 3.5036524256581392e-06 5.455478983869777 -0.49083866276783505 DLPTIPGVTSPSSDEPPMEAS(ph)QSHLRNSPEDK ddPTM_A459_Selumetinib_30min_R1 2 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDK 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPS(0.001)S(0.001)DEPPMEAS(0.412)QS(0.412)HLRNS(0.174)PEDK;DLPTIPGVTSPSSDEPPMEAS(0.775)QS(0.185)HLRNS(0.038)PEDK 62.831 0.0002177 36413000.0 4063.3 5544.5 4254.8 5093.2 5334.4 5023.7 5769.6 4543.4 1810.46 4030.9 True False 4157.96698419453 4895.347362431878 3677.021529943453 4203.768231204925 4851.904461864811 4973.166139154644 5334.394426868389 4422.894272956889 3072.218389233359 4548.305279290949 0.9141793984511808 1.0763014049916697 0.8084377156224387 0.9242493573035326 1.0667499571667254 1.0934108055143403 1.1728312193899144 0.9724268714096492 0.6754644203900706 1.0 12.15111337489451 -8.023246659726558 24.42667500230312 0.833136608379924 1.0101031018690625 0.229805247684725 0.12286446025715596 828.6710345315408 870727.9980962632 0.08360213328214001 0.032088568540585616 9.478799572217322e-09 8.023246659726558 0.1769664934891385 DLPTIPGVTSPSSDEPPMEAS(ph)QSHLRNSPEDK ddPTM_A459_Selumetinib_30min_R2 3 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDK 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPSSDEPPMEAS(0.333)QS(0.333)HLRNS(0.333)PEDK;DLPTIPGVTSPS(0.001)S(0.001)DEPPMEAS(0.393)QS(0.393)HLRNS(0.214)PEDK;DLPTIPGVTSPS(0.005)S(0.015)DEPPMEAS(0.691)QS(0.192)HLRNS(0.098)PEDK 100.23 2.44e-09 40668800.0 120920.0 105803.0 143510.0 155256.0 163137.0 118852.0 119530.0 119726.0 99820.0 157314.0 True False 114199.75048111276 113917.74988973455 134276.7228418737 134109.86496846168 142642.27159671587 135222.78416896448 125088.38184420177 120074.38283829384 119786.78920383283 152771.9360691412 0.7475178584463869 0.7456719658130004 0.8789357934241472 0.8778435910360298 0.933694206324381 0.8851284316234995 0.8187916253649461 0.785971467848328 0.7840889648058134 1.0 17.221020021655967 -12.09582365212749 2.161909076514029 3.905260505902699 0.8323226118495483 0.41775602042748083 0.06055393540759971 3123929.9149280605 209645.99293720745 44691588.453218535 0.01723716080043888 8.020036556611646e-13 12.09582365212749 -3.0729378940531507 DLPTIPGVTSPSSDEPPMEAS(ph)QSHLRNSPEDKR ddPTM_A459_Selumetinib_30min_R1 2 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKR 33 2 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPS(0.006)S(0.006)DEPPMEAS(0.704)QS(0.104)HLRNS(0.18)PEDKR;DLPTIPGVT(0.004)S(0.008)PS(0.152)S(0.058)DEPPMEAS(0.36)QS(0.057)HLRNS(0.36)PEDKR 62.284 0.0018264 21388700.0 1336.46 1935.96 1612.56 1800.0700000000002 1796.6299999999999 1508.27 2182.3 1552.05 408.93 950.92 True False 1367.5969177015293 1709.2969031966131 1393.583209158036 1485.721565998793 1634.1251337207889 1493.0981731995896 2017.6873540201914 1510.884592231093 693.9243429345008 1072.9798447451813 1.2745783850453554 1.5930372891604025 1.2987971917487358 1.3846686620209838 1.5229784060937999 1.391543541578995 1.8804522413926292 1.4081201987441883 0.6467263540251297 1.0 10.06740726088767 -8.200800498417 6.571031635896603 0.8259808627376992 1.480152254802789 0.6674163972193237 0.1824686501563538 0.11908067928726386 10.489504978471457 0.12503612234859438 0.0458078680803613 6.297954251459241e-09 8.200800498417 0.6541713920650898 DLPTIPGVTSPSSDEPPMEAS(ph)QSHLRNSPEDKR ddPTM_A459_Selumetinib_30min_R2 3 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKR 33 2 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPSSDEPPMEAS(0.397)QS(0.329)HLRNS(0.274)PEDKR;DLPTIPGVTSPSSDEPPMEAS(0.333)QS(0.333)HLRNS(0.333)PEDKR;DLPTIPGVT(0.001)S(0.001)PS(0.004)S(0.004)DEPPMEAS(0.35)QS(0.35)HLRNS(0.29)PEDKR 63.901 0.00036898 48606000.0 83768.7 84113.8 105783.3 121340.0 122733.0 86063.1 75286.2 84002.0 61592.1 113525.0 True False 79113.17100667526 90565.05799150451 98977.31764614848 104813.28267682469 107314.18329305873 97917.51082196372 78787.1574767751 84246.43191272032 73912.2410270625 110247.23827662703 0.7175977579426372 0.8214723507564249 0.8977759370062349 0.9507111861961773 0.9733956602503836 0.8881629358939028 0.7146406450480527 0.7641591139120715 0.6704226081528272 1.0 16.750382990768195 -7.245832811948352 24.013308348172053 0.7676521863001237 0.8813955848000804 0.13079910396382843 0.10500706099353942 776.0190435265503 1194035.8372138862 0.040552374182404614 0.03128394849078808 5.677631321159111e-08 7.245832811948352 0.11374339849995674 DLPTIPGVTSPSSDEPPMEASQS(ph)HLRNSPEDK ddPTM_A459_Selumetinib_30min_R1 1 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDK 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPSSDEPPMEAS(0.143)QS(0.428)HLRNS(0.428)PEDK 110.27 2.3389e-12 39899000.0 1795.2 2025.4 2106.7 2013.9 2197.5 2083.2 2721.4 1962.7 839.05 1755.5 True False 1837.0246671488735 1788.2652264170865 1820.6217112747647 1662.210170585016 1998.736513000136 2062.244899394262 2516.122606988291 1910.642820251903 1423.8065682126364 1980.835525018052 0.9273988899871594 0.9027832971648615 0.9191180632012205 0.8391459813756458 1.0090370895291374 1.041098502802482 1.2702329775539343 0.9645640923339612 0.7187909093056379 1.0 10.951893378371624 -6.316745172612038 10.2656613473245 1.0144499862134233 0.8991252566990068 0.13225393200941615 0.1269193115118056 1.3859572508515756 253.25724185216347 0.04203271725013516 0.04769309933257033 4.822306691367437e-07 6.316745172612038 -0.11532472951441652 DLPTIPGVTSPSSDEPPMEASQS(ph)HLRNSPEDK ddPTM_A459_Selumetinib_30min_R2 1 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDK 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPS(0.001)S(0.001)DEPPMEAS(0.18)QS(0.478)HLRNS(0.339)PEDK 71.524 3.912300000000001e-05 12102000.0 18616.0 18706.0 22551.0 25061.0 24484.0 16964.0 17085.0 17692.0 16830.0 22615.0 True False 17581.397245752512 20140.690050729896 21100.093211672327 21647.648567363663 21408.101030262846 19300.63701614038 17879.48635328525 17743.48079093174 20196.470269490146 21962.04618917345 0.8005354826372941 0.9170680125724615 0.9607526106594733 0.985684502295384 0.9747771608283167 0.8788177954773151 0.8141084031641477 0.8079156485737052 0.9196078587361467 1.0 14.422724855087907 -6.919337689606116 8.104865069369998 0.8661820184730548 0.9320261536913119 0.06077064877168137 0.07065253958373434 0.4857129858525228 42.83741330188466 0.025386832824708182 0.02238429876501586 1.204099317953859e-07 6.919337689606116 0.06584413521825716 DLPTIPGVTSPSSDEPPMEASQS(ph)HLRNSPEDKR ddPTM_A459_Selumetinib_30min_R1 1 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKR 33 2 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPSSDEPPMEAS(0.149)QS(0.425)HLRNS(0.425)PEDKR 98.073 2.5723000000000012e-11 15693000.0 6094.2 6977.7 5959.2 6813.5 6791.0 6139.3 7444.1 5948.5 2087.0 5000.3 True False 6236.183002751042 6160.747640155278 5149.973371542499 5623.650130235368 6176.7552490484295 6077.544216038402 6882.58554372071 5790.726456548858 3541.4865715508836 5642.137212046578 1.105287370437591 1.0919173725519136 0.9127699625146912 0.9967233902479831 1.0947545259729565 1.0771705805137428 1.219854336230186 1.0263356311478966 0.6276852969809781 1.0 12.462026036146025 -8.079582184705156 8.983964566699637 0.8162410184971406 1.068342046016352 0.4533348864101375 0.11149756548300582 0.35735400556933206 37.82843086364916 0.07416234537882065 0.027959442474620275 8.32564358864755e-09 8.079582184705156 0.2521010275192114 DLPTIPGVTSPSSDEPPMEASQSHLRNS(ph)PEDK ddPTM_A459_Selumetinib_30min_R1 2 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDK 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPS(0.001)S(0.001)DEPPMEAS(0.017)QS(0.461)HLRNS(0.521)PEDK;DLPTIPGVTSPSSDEPPMEAS(0.027)QS(0.074)HLRNS(0.899)PEDK 97.085 4.228e-09 22906000.0 4176.0 5869.2 4555.1 5414.2 5478.1 5162.1 6132.7 4939.5 1772.5 4283.8 True False 4273.292674918506 5182.031335482947 3936.5424393732796 4468.711607121205 4982.6068222371105 5110.173960811794 5670.105501534906 4808.488414242763 3007.803041722062 4833.667457745558 0.8840684040170995 1.0720703028875445 0.8144007575583818 0.9244971124276369 1.0308129108577566 1.057204287527715 1.1730441845868036 0.9947909028242214 0.6222610611953255 1.0 12.238902507959224 -8.072399309972516 24.923507570838446 0.8102611651001561 0.9976828170257926 0.2451908678873682 0.12811208995374437 197.6927331558385 68053.78868680452 0.08612682966880238 0.03255289342787084 8.464487929742557e-09 8.072399309972516 0.18742165192563653 DLPTIPGVTSPSSDEPPMEASQSHLRNS(ph)PEDK ddPTM_A459_Selumetinib_30min_R2 2 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDK 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPSSDEPPMEAS(0.269)QS(0.073)HLRNS(0.658)PEDK;DLPTIPGVTSPS(0.001)S(0.001)DEPPMEAS(0.288)QS(0.209)HLRNS(0.5)PEDK 97.839 3.7992e-09 23629800.0 99732.0 87680.0 108288.0 123287.0 126297.0 83947.0 86710.0 103009.0 82097.0 117354.0 True False 94189.29469882826 94404.7740643645 101320.86797506003 106495.09791806222 110430.44175049433 95509.93725500676 90742.18681260552 103308.73913594204 98518.69398183806 113965.68509769013 0.8264706575324865 0.8283613965330157 0.8890471538709998 0.934448802082625 0.9689797561067137 0.8380587294599835 0.7962237645026423 0.9064898705903178 0.864459279101327 1.0 16.79823997082923 DLPTIPGVTSPSSDEPPMEASQSHLRNS(ph)PEDKR ddPTM_A459_Selumetinib_30min_R2 4 DLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKR 33 2 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 DLPTIPGVTSPS(0.001)SDEPPMEAS(0.049)QS(0.064)HLRNS(0.885)PEDKR;DLPTIPGVTSPSSDEPPMEAS(0.058)QS(0.058)HLRNS(0.884)PEDKR;DLPTIPGVTSPSSDEPPMEAS(0.107)QS(0.107)HLRNS(0.786)PEDKR;DLPTIPGVTSPSS(0.001)DEPPMEAS(0.311)QS(0.311)HLRNS(0.378)PEDKR 70.718 3.952800000000001e-05 45382100.0 166771.0 145799.0 192924.0 220031.0 230224.0 151179.0 131737.0 131865.0 115514.0 213208.0 True False 157502.53545720823 156981.31448232496 180511.47987976868 190062.3982253537 201301.20289132601 172002.5349836762 137863.0315319133 132248.705318574 138620.0277308307 207052.1310590884 0.7606902409145466 0.7581728991599982 0.8718165756442007 0.9179446608598963 0.9722247332671926 0.8307209112210984 0.6658372982047214 0.6387217781440412 0.6694933639261671 1.0 17.659634525985737 -7.1463328045018235 5.637390229898841 0.7141620845715544 0.8590186823429365 0.16347472665288232 0.11323453559684869 0.3257503945922562 13.937037978667858 0.04404714534070681 0.033968558549533276 7.13949009640605e-08 7.1463328045018235 0.14485659777138216 DLQAALTPGALTAAAAGTGT(ph)QGPR ddPTM_A459_Selumetinib_30min_R1 2 DLQAALTPGALTAAAAGTGTQGPR 24 0 P55042 P55042 RRAD GTP-binding protein RAD 1 DLQAALTPGALT(0.002)AAAAGT(0.002)GT(0.996)QGPR;DLQAALTPGALT(0.002)AAAAGT(0.002)GT(0.997)QGPR 86.214 0.00023011 27593000.0 6124.7 7845.0 7225.700000000001 8578.400000000001 7857.2 6931.700000000001 7339.9 6377.7 3653.6000000000004 5552.2 True False 6267.393593408372 6926.503752958444 6244.489627929028 7080.343476511491 7146.51764730133 6861.9733914800345 6786.2454336126075 6208.542678310772 6199.892351613954 6264.878953007823 1.0004013869093737 1.1056085528409083 0.996745455860882 1.1301644500429104 1.1407271714117038 1.0953082163200523 1.0832205194251154 0.9910076036393324 0.989626838462271 1.0 12.613070919415541 -7.761344243274842 24.999285501639715 0.9927378928009378 1.0817338958833282 0.4264935452176748 0.045261042784769834 2.4322334694138728 639710.9139429062 0.023461763520678726 0.01242209641167525 1.7324302435230414e-08 7.761344243274842 0.08899600308239042 DLQEQDADAGS(ph)ER ddPTM_A459_Selumetinib_30min_R1 2 DLQEQDADAGSER 13 0 Q6P158;A0A087WW12;A0A087WZ11;Q6P158-3;Q6P158-2 Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 1 DLQEQDADAGS(1)ER;DLQEQDADAGS(1)ER 260.08 1.0889e-29 66842000.0 5375.5 6332.7 5404.299999999999 4283.6 5811.5 4371.7 5878.5 5589.9 2722.0 5746.799999999999 True False 5500.7386910978 5591.264540007642 4670.425743694983 3535.549673130728 5285.850851103661 4327.724667186011 5435.080012192496 5441.637693445817 4619.035192985868 6484.457758572337 0.8482958631083566 0.8622562977784981 0.7202492355695839 0.5452344366738753 0.8151569565112612 0.66739962357914 0.8381703165553692 0.8391816087092354 0.7123240469690139 1.0 12.662770223560663 -10.691725852561104 6.991486622085579 1.0000003712088739 0.7597780479923518 0.35800415759979065 0.09603719887896729 5.796049989263552e-07 6.883350169148327e-08 0.0969849562830419 0.023522270539085312 2.0336403368462724e-11 10.691725852561104 -0.24022232321652204 DLQEQDADAGS(ph)ER ddPTM_A459_Selumetinib_30min_R2 2 DLQEQDADAGSER 13 0 Q6P158;A0A087WW12;A0A087WZ11;Q6P158-3;Q6P158-2 Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 1 DLQEQDADAGS(1)ER;DLQEQDADAGS(1)ER 276.75 2.3340999999999997e-48 238390000.0 145718.0 111718.0 139173.0 164712.0 183815.0 147620.0 141842.0 148069.0 138561.0 130025.0 True False 137619.57691537202 120286.41137001183 130218.76070010522 142277.94145595146 160722.5163730502 167953.31503906168 148437.93405459088 148499.85627585763 166277.0717178147 126270.8404044784 1.0898761461833997 0.952606405284887 1.0312654947332307 1.1267679933086543 1.2728395238220804 1.330103723876894 1.175551960999907 1.1760423530893902 1.3168287403899896 1.0 16.94616199194006 -5.941420980816653 3.073087067016276 1.2241275648774443 1.0165821754744206 0.44220291598613237 0.09338041537310338 0.2074284309096883 3.988999810513957 0.02683692722642452 0.04133689023003971 1.1444030831779344e-06 5.941420980816653 -0.2075453894030237 DLQS(ph)PDFTTGFHSDK ddPTM_A459_Selumetinib_30min_R1 2 DLQSPDFTTGFHSDK 15 0 E9PDR5;Q9P2D0-2;Q9P2D0;E7EPI0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 DLQS(0.982)PDFT(0.017)T(0.001)GFHSDK;DLQS(0.998)PDFT(0.002)TGFHSDK 111.66 0.0021168000000000003 33340000.0 10200.8 13162.8 8255.8 8427.9 9002.7 9225.9 12056.8 11094.5 5035.6 10576.7 True False 10438.458792698437 11621.693256780296 7134.707705863298 6956.125476276604 8188.407374555779 9133.095822446965 11147.34586901463 10800.23781998509 8545.045414327567 11934.322470782363 0.8746586845004312 0.9738041925071619 0.5978309806300698 0.5828672296484871 0.6861225171854253 0.7652797923641357 0.9340577059406254 0.9049728500655365 0.7160059094471067 1.0 13.542829044353054 -7.133542809758007 5.513456399523832 0.8800908575578448 0.7378495022718993 0.22545307458964392 0.12871303817690657 0.4103813560868639 16.705399033427113 0.05449513226297466 0.042053715790231906 7.352875123257237e-08 7.133542809758007 -0.1422413552859455 DLQS(ph)PDFTTGFHSDK ddPTM_A459_Selumetinib_30min_R2 4 DLQSPDFTTGFHSDK 15 0 E9PDR5;Q9P2D0-2;Q9P2D0;E7EPI0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 DLQS(0.991)PDFT(0.008)T(0.001)GFHSDK;DLQS(1)PDFTTGFHSDK;DLQS(1)PDFTTGFHSDK;DLQS(0.997)PDFT(0.002)T(0.001)GFHSDK 144.72 0.00024621 77485200.0 431815.0 292592.0 386187.0 446800.0 444916.0 401956.0 503865.0 568709.0 487823.0 387323.0 True False 407816.4509924053 315032.8655684356 361340.14886861393 385945.0692270089 389021.67448049405 457321.7904067274 527295.7208895568 570363.8490351574 585401.2309134583 376139.97860398877 1.084214585500805 0.8375415629512529 0.960653398795036 1.026067664116457 1.0342470798353172 1.2158287244659234 1.4018603469021549 1.5163606143436648 1.5563387680462062 1.0 18.520910127979263 -6.9141561097446775 1.8627226304308186 1.414843340257822 0.9678069804755415 0.5723591629403759 0.15397459082845288 0.21827077795280297 1.5454264635371258 0.06497945737982869 0.05319118929973884 1.2185515045775197e-07 6.9141561097446775 -0.4470363597822805 DLQS(ph)PDFTTGFHSDKIEAK ddPTM_A459_Selumetinib_30min_R1 2 DLQSPDFTTGFHSDKIEAK 19 1 E9PDR5;Q9P2D0-2;Q9P2D0;E7EPI0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 DLQS(0.581)PDFT(0.401)T(0.018)GFHSDKIEAK;DLQS(1)PDFTTGFHSDKIEAK 139.26 7.43e-05 376200000.0 7391.3 8375.9 9334.3 10009.9 8007.7 7704.400000000001 7691.5 7412.5 3716.25 5823.700000000001 True False 7563.502909033802 7395.245734149729 8066.753329639739 8261.858874094516 7283.404948874261 7626.900731035499 7111.323962537823 7215.896420806659 6306.204825838997 6571.228622641772 1.1510028555349692 1.1253977237481483 1.227586771497342 1.2572776490575175 1.1083779559546323 1.16065064374055 1.0821909221108368 1.0981046064876856 0.9596690646419437 1.0 12.681947421127092 -7.723516669205674 0.9705752953952557 0.9822600380081311 1.1805902319273056 0.7076114656874581 0.04686738364671945 0.3186139965986717 0.5451087117690766 0.042653088019056803 0.01789705413645989 1.890093683718948e-08 7.723516669205674 0.1983301939191745 DLQS(ph)PDFTTGFHSDKIEAK ddPTM_A459_Selumetinib_30min_R2 5 DLQSPDFTTGFHSDKIEAK 19 1 E9PDR5;Q9P2D0-2;Q9P2D0;E7EPI0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 DLQS(0.989)PDFT(0.008)T(0.002)GFHSDKIEAK;DLQS(0.996)PDFT(0.003)T(0.001)GFHSDKIEAK;DLQS(1)PDFTTGFHSDKIEAK;DLQS(0.998)PDFT(0.002)TGFHSDKIEAK;DLQS(1)PDFTTGFHSDKIEAK 67.11 0.0091241 47733700.0 262796.0 242564.0 273100.0 274979.0 304551.0 202358.0 218899.0 249231.0 189657.0 261626.0 True False 248190.85037573997 261167.8788338104 255529.0433287972 237526.38583476684 266290.5806595156 230230.9776769707 229078.23724013974 249956.22094758664 227593.6994593405 254072.17759401668 0.9768517463266895 1.0279278955570332 1.00573406245649 0.9348775929897825 1.0480902835611647 0.9061636730837095 0.9016266141749102 0.9838000497126177 0.895783637604798 1.0 17.954878874838705 -6.774665121408144 24.99907815176837 0.9342217872675252 0.9971658013686401 0.34057527335496274 0.042447013370509074 260.86559721912636 493080.9537913804 0.014318602520168085 0.01270044927505711 1.6800990203743176e-07 6.774665121408144 0.06294401410111483 DLQSPDFT(ph)TGFHSDKIEAK ddPTM_A459_Selumetinib_30min_R2 3 DLQSPDFTTGFHSDKIEAK 19 1 E9PDR5;Q9P2D0-2;Q9P2D0;E7EPI0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 DLQS(0.045)PDFT(0.803)T(0.152)GFHS(0.001)DKIEAK;DLQS(0.013)PDFT(0.937)T(0.049)GFHSDKIEAK;DLQS(0.008)PDFT(0.853)T(0.139)GFHSDKIEAK 108.96 0.00099237 38725000.0 74541.0 70711.0 83784.0 89738.0 86773.0 58537.0 65251.0 72627.0 52300.0 80511.0 True False 70398.30963126542 76134.30632829918 78393.4286571218 77515.52959331547 75871.79997953761 66599.94040402072 68285.30079240358 72838.33254595299 62761.46138409592 78186.43823730001 0.9003902878604445 0.9737533521763391 1.0026473954369626 0.9914191174440214 0.9703959112354326 0.8518093662469487 0.8733650276426974 0.9315980390983506 0.8027154427166965 1.0 16.254630767330767 -6.745682167482515 24.62651646954468 0.8864641751045134 0.971313257838567 0.32258931113945577 0.05453144281893682 214.39703422482225 335074.4687736084 0.017236723955802252 0.01717756493523214 1.7960475589922083e-07 6.745682167482515 0.08484908273405367 DLRS(ph)PLTATPTFVTDSESTR ddPTM_A459_Selumetinib_30min_R1 1 DLRSPLTATPTFVTDSESTR 20 1 A0A087WUK4;P13056-2;P13056-3;P13056 A0A087WUK4 NR2C1 Nuclear receptor subfamily 2 group C member 1 1 DLRS(0.993)PLT(0.007)ATPTFVTDSESTR 102.16 0.0003616 5735500.0 1101.3 1754.2 1612.0 1692.4 1377.1 1467.2 1464.3 1297.7 993.76 1006.8 True False 1126.958147243235 1548.8174484945448 1393.0992540821771 1396.8541102825768 1252.5415481467517 1452.4413001110129 1353.8466720853066 1263.28078047633 1686.338138641308 1136.0325870624745 0.992012165916205 1.363356532315186 1.2262845889697753 1.2295898253187687 1.102557763228908 1.2785208071070393 1.191732250908445 1.1120110416400033 1.4844100053518714 1.0 10.149788503764485 -14.522869274077554 24.999923664188543 5.278493005578255e-06 1.2068188264376907 0.0 0.14717402719215966 0.0 0.0 0.0 0.030843897407072083 3.0000654254644343e-15 14.522869274077554 1.206813547944685 DLRS(ph)PLTATPTFVTDSESTR ddPTM_A459_Selumetinib_30min_R2 2 DLRSPLTATPTFVTDSESTR 20 1 A0A087WUK4;P13056-2;P13056-3;P13056 A0A087WUK4 NR2C1 Nuclear receptor subfamily 2 group C member 1 1 DLRS(0.979)PLT(0.021)ATPTFVTDSESTR;DLRS(0.942)PLT(0.051)AT(0.007)PTFVTDSESTR 114.75 0.00015056 9613800.0 20000.1 18810.5 18393.6 20143.0 25862.0 15960.5 13040.599999999999 14571.8 12411.099999999999 14387.0 True False 18888.57450874381 20253.204864709456 17210.17580143746 17399.488651386848 22612.984350786544 18158.914000006396 13647.01373945868 14614.201525508644 14893.666795108087 13971.609928084818 1.351925412029664 1.4495970735625667 1.2317961845501204 1.2453460081512533 1.6184952533874712 1.2997009001449813 0.9767674455344151 1.0459926666097463 1.0659950336267126 1.0 13.770210649505279 -7.1720536652971125 4.820516048824635 1.026618227255323 1.3748254383582823 0.7238192407922789 0.10469463524501216 0.12589838378466203 4.961794360248166 0.04245845775469695 0.03241889864595401 6.728935024280521e-08 7.1720536652971125 0.34820721110295927 DLS(ph)LEEIQK ddPTM_A459_Selumetinib_30min_R1 1 DLSLEEIQK 9 0 A2A2D0;P16949;P16949-2;E5RGX5;Q93045;Q93045-2 A2A2D0 STMN1;STMN2 Stathmin;Stathmin-2 1 DLS(1)LEEIQK 118.9 0.007066100000000001 7174900.0 1567.3 1996.4 2319.1 2183.3 1884.2 1632.6 1676.3 1759.8 988.41 1725.1 True False 1603.8150405650786 1762.6605598988187 2004.178957904452 1802.027640616845 1713.7744426825282 1616.1775262821977 1549.855341403127 1713.1243873639874 1677.259579389847 1946.5333888969767 0.823933999649447 0.9055383123418441 1.0296144773761835 0.9257625124211112 0.8804238614440907 0.8302850264479775 0.7962130782053365 0.8800899060533182 0.8616649418689312 1.0 10.926691376114793 -6.3578571214224615 4.030130175710186 0.8610339703345423 0.9277879603641509 0.08230773788013501 0.06822386303590451 0.4402901427553568 12.815560475930402 0.022060419606518708 0.025360872434155912 4.3867499376020694e-07 6.3578571214224615 0.06675399002960858 DLS(ph)LEEIQK ddPTM_A459_Selumetinib_30min_R2 1 DLSLEEIQK 9 0 A2A2D0;P16949;P16949-2;E5RGX5;Q93045;Q93045-2 A2A2D0 STMN1;STMN2 Stathmin;Stathmin-2 1 DLS(1)LEEIQK 138.99 0.0024186 3080900.0 19640.0 20205.0 21952.0 22454.0 23734.0 17799.0 20153.0 20017.0 15022.0 21764.0 True False 18548.4874251493 21754.658530685225 20539.63221953045 19395.726464689506 20752.322735347905 20250.650686765068 21090.15443241192 20075.24615600726 18026.819749749313 21135.61677033699 0.8775938562238398 1.029289032209225 0.9718018850699932 0.9176797003582431 0.9818650177492325 0.9581291573750553 0.9978490176833223 0.9498301551427674 0.8529119327640936 1.0 14.367388592628984 -8.013439588666305 24.69506476971282 0.9180943237001151 0.9646095367730046 0.06376161617033771 0.051391827309012615 1091.8281296354917 2006208.1615885578 0.02979828645954582 0.012366324334504322 9.695281234510194e-09 8.013439588666305 0.04651521307288953 DLS(ph)LEVDR ddPTM_A459_Selumetinib_30min_R1 1 DLSLEVDR 8 0 E7EMW7;O95071-2;O95071;E5RFK7 E7EMW7 UBR5 E3 ubiquitin-protein ligase UBR5 1 DLS(1)LEVDR 87.568 0.032289 1959900.0 1374.0 1908.4 1196.6 942.18 1303.5 943.11 1319.5 1659.8 737.38 1368.8 True False 1406.011526661404 1684.9636408089095 1034.108292453308 777.645949909027 1185.5986551516166 933.6231696753663 1219.969052664456 1615.7767122097655 1251.2800038956357 1544.498813241077 0.9103351291743228 1.090945247975343 0.6695429504949038 0.5034940417190507 0.7676267828679513 0.6044829310785876 0.789880213701423 1.0461495330120159 0.8101527778256223 1.0 10.59292304709292 -7.6223149794667915 6.945800004443674 0.9445431320307047 0.7529506016963968 0.2250359602938875 0.16187318550710084 0.3755158034855848 22.706617034624404 0.08439305460913481 0.048282224471545475 2.38608010998536e-08 7.6223149794667915 -0.1915925303343079 DLS(ph)LEVDR ddPTM_A459_Selumetinib_30min_R2 2 DLSLEVDR 8 0 E7EMW7;O95071-2;O95071;E5RFK7 E7EMW7 UBR5 E3 ubiquitin-protein ligase UBR5 1 DLS(1)LEVDR;DLS(1)LEVDR 105.4 0.014171 3834400.0 26145.0 19977.9 24898.0 27782.0 30040.0 24291.0 28413.0 29675.0 24150.0 23333.0 True False 24691.965566727496 21510.140690926823 23296.089786892713 23998.043673376844 26266.106638992624 27636.864758256645 29734.260799291413 29761.349337039286 28980.6748073789 22659.315663585417 1.0897048230988124 0.9492846567072026 1.0281020897877609 1.059080690240916 1.1591747530665053 1.2196689947998025 1.3122311918305531 1.3134266620799662 1.278973965394383 1.0 14.46781667037866 -6.4015410952357685 1.718555528775491 1.252382519430109 1.0156139510495126 0.4961177592321858 0.09071903533979567 0.2591270302800964 1.5252660415823822 0.03229080005531845 0.03867774149034801 3.9669698959296365e-07 6.4015410952357685 -0.23676856838059646 DLS(ph)LEVDRDR ddPTM_A459_Selumetinib_30min_R1 1 DLSLEVDRDR 10 1 E7EMW7;O95071-2;O95071;E5RFK7 E7EMW7 UBR5 E3 ubiquitin-protein ligase UBR5 1 DLS(1)LEVDRDR 149.94 0.0034604 8413600.0 4278.7 4906.6 4118.5 4626.1 4004.8 3994.4 4305.5 4339.8 2518.5 4029.1 True False 4378.385385099091 4332.132990983543 3559.230321301146 3818.238477651988 3642.5665471048687 3954.219962625018 3980.732668622063 4224.694406342895 4273.710556037807 4546.2742317574675 0.9630711131577571 0.9528974210842659 0.7828894914518263 0.8398610121184792 0.8012201555419041 0.8697715450166372 0.8756032886918963 0.9292651940861344 0.9400468027608851 1.0 12.150468994964791 -8.187224509212532 1.236731033744398 0.993404911985391 0.8639715487058017 0.3771573828527107 0.05446558665003275 0.5032479532666214 1.4700765684861403 0.05557774642438418 0.018139283649213443 6.4979369163656545e-09 8.187224509212532 -0.12943336327958932 DLS(ph)MSEEDQMMR ddPTM_A459_Selumetinib_30min_R1 2 DLSMSEEDQMMR 12 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 DLS(0.873)MS(0.127)EEDQMMR;DLS(0.996)MS(0.004)EEDQMMR 193.11 0.00015352 8732000.0 1752.6399999999999 1789.52 1712.5900000000001 2178.1 1811.79 1591.05 1714.23 1801.15 956.3699999999999 1198.79 True False 1793.4731019562182 1580.0021664747217 1480.0296845834955 1797.7357230007556 1647.9139143975053 1575.0454815578146 1584.9242509655098 1753.377651040258 1622.8900394988596 1352.66637370344 1.3258798598252293 1.1680649398778675 1.0941572240990585 1.3290311328422901 1.2182707772099874 1.1644005589090878 1.1717037414230793 1.2962380710623551 1.199771112115088 1.0 10.401590336573719 -11.088520504804276 2.1216697447019914 0.9741243146742915 1.2160123862735055 0.4461329352858594 0.07302314391041562 627210.7074462193 452383.1217440552 90993.44432128705 0.01922700333573264 8.156042782371092e-12 11.088520504804276 0.241888071599214 DLS(ph)MSEEDQMMR ddPTM_A459_Selumetinib_30min_R2 2 DLSMSEEDQMMR 12 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 DLS(0.998)MS(0.002)EEDQMMR;DLS(0.998)MS(0.002)EEDQMMR 149.32 0.00057913 5812800.0 19532.5 13798.5 17275.6 22020.9 22891.0 16669.1 16922.7 21080.9 16687.8 20385.4 True False 18446.961844792702 14856.800580829506 16164.106704251088 19021.61543182866 20015.227931863516 18965.117217976025 17709.639081693895 21142.24192886914 20025.826296090185 19796.82053436994 0.9318143695229392 0.7504639724866982 0.8165001383019069 0.960841939179303 1.0110324482213895 0.9579880357580669 0.8945698654462003 1.0679614886725557 1.0115678051090407 1.0 14.272981124620767 -5.8136385078215564 4.791896849842029 0.986982842647466 0.8240581721016241 0.5893889704362744 0.058801261621184375 0.13325841006800138 6.4090374913842 0.016890493107062476 0.026350985185658586 1.5358948783330667e-06 5.8136385078215564 -0.16292467054584192 DLS(ph)PEPAPDEGPR ddPTM_A459_Selumetinib_30min_R2 1 DLSPEPAPDEGPR 13 0 Q8TBE0-3;Q8TBE0-2;Q8TBE0 Q8TBE0-3 BAHD1 Bromo adjacent homology domain-containing 1 protein 1 DLS(1)PEPAPDEGPR 158.31 0.00036465 7519900.0 31460.0 30556.0 28456.0 35346.0 38286.0 28791.0 36242.0 29730.0 30053.0 36261.0 True False 29711.579144358282 32899.546946974406 26625.171940550194 30531.813824749046 33476.1703988173 32756.698911323834 37927.32481216058 29816.509377933562 36064.439750979625 35214.050712607495 0.8437421581187423 0.9342732881109744 0.7560951211732574 0.8670349819714978 0.9506480998742929 0.9302167245302493 1.0770508943062795 0.8467219412295138 1.0241491399359992 1.0 15.103863571160044 -6.289200520925831 3.1364776602735196 0.9697275310729963 0.8476031631013121 0.4273746901269738 0.06932352491968045 0.2615542547110993 5.255561153090645 0.021647965028271945 0.026395587131709468 5.138063639335461e-07 6.289200520925831 -0.12212436797168413 DLS(ph)PEPAPDEGPRR ddPTM_A459_Selumetinib_30min_R2 1 DLSPEPAPDEGPRR 14 1 Q8TBE0-3;Q8TBE0-2;Q8TBE0 Q8TBE0-3 BAHD1 Bromo adjacent homology domain-containing 1 protein 1 DLS(1)PEPAPDEGPRR 119.0 0.0011687999999999998 9001600.0 34132.0 36480.0 44505.0 47625.0 50278.0 32071.0 34601.0 40196.0 33553.0 47349.0 True False 32235.08008122178 39277.898698312165 41641.59675338021 41138.392842292546 43961.628148977084 36488.48913844836 36210.01506058079 40312.963705193964 40264.537549150504 45981.9113425237 0.7010382809252872 0.8542032627945215 0.9056082171788801 0.8946646983821243 0.9560635229254101 0.793540069847077 0.787483904069339 0.8767135277370008 0.8756603710797507 1.0 15.488778815746235 -14.522878745280336 0.30475808413617805 2.258610022395004 0.8459116504672377 0.3122816289105743 0.06808761202526037 389.247334773066 3.564857665449241 313.6823552854945 0.07008847415230456 3.0000000000000132e-15 14.522878745280336 -1.4126983719277664 DLS(ph)PQHMVVR ddPTM_A459_Selumetinib_30min_R1 2 DLSPQHMVVR 10 0 A0A2R8Y5E8;D6RB22;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 A0A2R8Y5E8 HARS2 Probable histidine--tRNA ligase, mitochondrial 1 DLS(1)PQHMVVR;DLS(1)PQHMVVR 106.26 0.0079448 20362000.0 5154.9 7127.3 6017.1 7579.099999999999 5478.6 6272.299999999999 5516.8 5269.8 2851.73 4547.1 True False 5274.999140310678 6292.832402608122 5200.010869564435 6255.552462327272 4983.061597325388 6209.206356792737 5100.663334398837 5130.027785277153 4839.177527881553 5130.764577504745 1.0281117094006442 1.2264901863161548 1.0134962910524665 1.219224224349336 0.9712122866001407 1.2101912420648373 0.9941331856780403 0.999856397186723 0.9431688893110352 1.0 12.324958114389727 -7.404986499333318 8.464403515244863 0.9822946035296705 1.1106614695681452 0.34784081994691773 0.08542375289113827 0.3298645662532077 21.774032424873518 0.03272231627642153 0.021996553224274962 3.935623097143226e-08 7.404986499333318 0.1283668660384747 DLS(ph)PQHMVVR ddPTM_A459_Selumetinib_30min_R2 4 DLSPQHMVVR 10 0 A0A2R8Y5E8;D6RB22;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 A0A2R8Y5E8 HARS2 Probable histidine--tRNA ligase, mitochondrial 1 DLS(1)PQHMVVR;DLS(1)PQHMVVR;DLS(1)PQHMVVR;DLS(1)PQHMVVR 112.02 0.005616899999999999 17284300.0 117535.0 82510.0 93651.0 111807.0 78996.0 69803.0 125669.0 96323.0 77711.0 73560.0 True False 111002.87522988404 88838.25168853455 87625.59661949908 96578.69372216718 69071.81624679973 79417.72964145524 131512.85750839952 96603.28398286892 93255.3714267585 71436.13166816713 1.5538757857929808 1.2436038964316154 1.226628522195669 1.3519586162754653 0.9669030871891267 1.1117305456902955 1.8409851490741256 1.3523028434911264 1.3054370281406813 1.0 16.124366338868434 DLS(ph)PTLIDNSAAK ddPTM_A459_Selumetinib_30min_R1 1 DLSPTLIDNSAAK 13 0 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 DLS(1)PTLIDNSAAK 187.63 0.00014234 28388000.0 3772.9 3853.8 3755.4 3564.3 3562.4 3789.1 3936.4 3971.5 1847.5 3075.7 True False 3860.8012292145654 3402.595304416988 3245.437306935611 2941.8619151974626 3240.181548992802 3750.9850942275343 3639.4741787861785 3866.1629187498984 3135.0725639387915 3470.4960548550393 1.1124638000419307 0.9804348573331291 0.9351508417349782 0.8476776428205283 0.9336364305788392 1.0808210223953736 1.048689905206706 1.11400873467104 0.9033499863954583 1.0 11.760926173612843 -6.752097958526625 24.97436061882373 1.0377067265090039 0.95507521814517 0.1424745918384659 0.08067225660895468 342.9555896694855 916893.4553262087 0.027771372357064582 0.027408402073353922 1.7697097413836102e-07 6.752097958526625 -0.08263150836383382 DLS(ph)PTLIDNSAAK ddPTM_A459_Selumetinib_30min_R2 3 DLSPTLIDNSAAK 13 0 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 DLS(0.5)PT(0.5)LIDNSAAK;DLS(1)PTLIDNSAAK;DLS(1)PTLIDNSAAK 252.52 4.2167e-23 45413100.0 140861.0 135566.0 154567.0 154144.0 153036.0 113471.0 140321.0 151383.0 118766.0 118985.0 True False 133032.50953126032 145963.47628660622 144622.32749982527 133149.3212867687 133810.24952080136 129100.60026281909 146846.20454078648 151823.4994671951 142522.5185993026 115549.59388984312 1.1513022681679366 1.263210638591751 1.2516039445166554 1.1523131912839428 1.1580330576355522 1.1172743747234157 1.2708500272253604 1.3139249940759894 1.2334315838026533 1.0 16.81815266376084 -7.289474177035601 24.763876537555053 1.2307120525314021 1.1866532996092276 0.0 0.08939351672785978 2324.1808406230684 2053000.3060778312 0.03676091338593977 0.024789080234186762 5.134827080577947e-08 7.289474177035601 -0.04405875292217454 DLS(ph)SEGQTK ddPTM_A459_Selumetinib_30min_R1 2 DLSSEGQTK 9 0 Q7L2Z9 Q7L2Z9 CENPQ Centromere protein Q 1 DLS(0.5)S(0.5)EGQTK;DLS(0.814)S(0.186)EGQTK 150.09 0.0013564 19600300.0 4080.0 5432.6 5363.1 5556.5 4323.799999999999 4867.9 5472.6 4727.5 2605.9 4374.6 True False 4175.056061701989 4796.548666452778 4634.820477399582 4586.161583423032 3932.713053428889 4818.933345699565 5059.797375984463 4602.111342915812 4422.021972594369 4936.1225222124585 0.8458169429373593 0.9717239887924984 0.9389597718741739 0.9291020558718693 0.796721117786634 0.9762588598671235 1.025055061582339 0.9323332883668097 0.8958493134429611 1.0 12.269162489521083 DLS(ph)TPGLEK ddPTM_A459_Selumetinib_30min_R1 3 DLSTPGLEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DLS(0.5)T(0.5)PGLEK;DLS(0.5)T(0.5)PGLEK;DLS(0.5)T(0.5)PGLEK 150.04 0.0013618 70628000.0 42106.6 45904.5 46292.6 46876.7 45064.799999999996 39211.6 40655.8 41824.8 26203.4 36920.8 True False 43087.60185481883 40529.97979957691 40006.31918705 38690.56432964028 40988.69679683663 38817.16690528421 37589.100273827644 40715.47043790278 44465.255979385 41659.94431904669 1.0342693097436384 0.97287647552248 0.9603065928429323 0.9287233807451627 0.9838874599286689 0.9317623328540365 0.9022839777690754 0.9773289691913462 1.067338343970271 1.0 15.346373290682957 -8.077384154757741 6.443121550259794 1.0316408102823773 0.9571901660281905 0.385847701720029 0.036974335710264185 0.25130928645670675 17.004677609425517 0.025850752720006583 0.00965507788105375 8.36788773978508e-09 8.077384154757741 -0.07445064425418679 DLS(ph)TPGLEK ddPTM_A459_Selumetinib_30min_R2 7 DLSTPGLEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DLS(0.5)T(0.5)PGLEK;DLS(0.975)T(0.025)PGLEK;DLS(0.922)T(0.078)PGLEK;DLS(0.982)T(0.018)PGLEK;DLS(0.5)T(0.5)PGLEK;DLS(0.981)T(0.019)PGLEK;DLS(0.792)T(0.208)PGLEK 132.32 0.0033917 223396000.0 2573810.0 1954772.0 2350060.0 2684350.0 2861800.0 2062363.0 2160564.0 2528470.0 1457184.0 2027970.0 True False 2430767.9439777774 2104696.7268173574 2198859.69815186 2318736.899237964 2502275.0991833946 2346434.782982685 2261034.5070763486 2535827.429089258 1748661.517122803 1969417.2368011533 1.2342574740160077 1.0686901117184966 1.1165027181966687 1.177372095617583 1.2705662631691705 1.1914360954786334 1.1480728739578099 1.287602942486734 0.8879081001459522 1.0 20.90933735943409 -8.268803388027816 24.99999825072438 0.943954022904392 1.1818713968042147 0.6698763736483517 0.06812466026673786 377.14835294145416 1280359.6924989077 0.06222084996473005 0.01735981424634751 5.3851352091742924e-09 8.268803388027816 0.2379173738998227 DLSHIGDAVVISCAK ddPTM_A459_Selumetinib_30min_R1 2 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 ; 135.02 0.00057803 23518000.0 8623.5 9412.1 11088.3 12392.5 9891.8 9018.4 9274.1 9049.3 5601.6 8023.5 False True 8824.410771589974 8310.126956433418 9582.569763672087 10228.382511035705 8997.088436539128 8927.683084052045 8574.547170379257 8809.28316773095 9505.50607532316 9053.394380508316 0.9747074302417071 0.9179017954111078 1.0584504950213005 1.129784264458544 0.9937806814104538 0.9861144570563585 0.9471085440439884 0.9730364985200545 1.0499383629844101 1.0 13.144243086558177 -5.25423877281592 24.923526051289084 1.0158737271358558 0.9463046131634553 0.2380078918567362 0.05074603903872141 877.3438722085424 3036737.896012741 0.014432089922467821 0.03662894307522391 5.568794953414778e-06 5.25423877281592 -0.06956911397240051 DLSHIGDAVVISCAK ddPTM_A459_Selumetinib_30min_R2 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 78.615 0.045867000000000005 3015900.0 54677.0 43701.0 54766.0 56230.0 68122.0 41194.0 52892.0 50032.0 39915.0 56698.0 False True 51638.27122937309 47052.72617913757 51242.4151847123 48571.37699783958 59563.90534159307 46868.099578099886 55351.58280350972 50177.58483675655 47899.11531828281 55060.981420904514 0.9378378281097627 0.8545566200400758 0.9306484167617387 0.8821378723082279 1.0817806694411547 0.8512034905412327 1.0052778097139925 0.9113093072784582 0.8699284698927902 1.0 15.748742704674592 DLSLEEIQK ddPTM_A459_Selumetinib_30min_R1 1 DLSLEEIQK 9 0 A2A2D0;P16949;P16949-2;E5RGX5;Q93045;Q93045-2 A2A2D0 STMN1;STMN2 Stathmin;Stathmin-2 0 123.35 0.041723 0.0 1329.0 1075.2 1345.1 1522.4 1728.2 1467.6 1137.5 1281.1 880.84 1345.1 False True 1359.9631142161616 949.3150841530811 1162.4428081054195 1256.5414189873522 1571.8846151384914 1452.837276474183 1051.6974591934966 1247.1210664007292 1494.7211459917971 1517.7566873835272 0.8960350005511178 0.6254725095559374 0.7658953623912961 0.8278938445354598 1.0356631126747171 0.9572267337386869 0.6929288916568875 0.8216870838175327 0.9848226388437522 1.0 10.567724814519373 -1.5228787559216528 0.07726496499106503 1.1246539333183636 0.15717780463888478 0.2067221274314498 0.11648756883191673 364.55977922384113 2.068929644846249 4.0716496613380935 37.81277642266798 0.029999999264923995 1.5228787559216528 -0.9674761286794789 DLSPPDNHLS(ph)PQNDDALETR ddPTM_A459_Selumetinib_30min_R1 1 DLSPPDNHLSPQNDDALETR 20 0 O94972-2;O94972-3;O94972 O94972-2 TRIM37 E3 ubiquitin-protein ligase TRIM37 1 DLSPPDNHLS(1)PQNDDALETR 71.002 0.006804300000000001 2392000.0 650.55 776.54 1005.9 741.42 1038.1 549.85 783.22 747.82 476.45 751.42 True False 665.7065492500559 685.6223357963478 869.3043050131896 611.9449151770905 944.2040382914411 544.319008223855 724.1410848259602 727.9853843382978 808.5008514688164 847.8720764506203 0.7851497504633606 0.8086388912187252 1.025277667655113 0.7217420318154916 1.1136161509694806 0.6419824680422247 0.8540687975683486 0.8586028536118389 0.9535646637325049 1.0 9.727702802921645 -8.374763685255731 2.7862702036378675 0.9984651352321646 0.8522784273641425 0.1368254360458716 0.12882696020967838 0.5150900382124829 7.552748237555634 0.11565351386930672 0.03159920380168785 4.219260256141022e-09 8.374763685255731 -0.14618670786802213 DLSPPDNHLS(ph)PQNDDALETR ddPTM_A459_Selumetinib_30min_R2 2 DLSPPDNHLSPQNDDALETR 20 0 O94972-2;O94972-3;O94972 O94972-2 TRIM37 E3 ubiquitin-protein ligase TRIM37 1 DLSPPDNHLS(1)PQNDDALETR;DLS(0.007)PPDNHLS(0.993)PQNDDALETR 116.92 0.00017521 8900100.0 26081.4 25171.5 27740.9 28472.0 37190.0 25168.9 29654.0 27532.0 22412.1 31392.0 True False 24631.900200116546 27102.073110870726 25956.08069600819 24594.064483060447 32517.859717181618 28635.687514473917 31032.969758286235 27612.113561832044 26895.14624639572 30485.631393788764 0.8079839279672956 0.8890113759097863 0.8514201448127645 0.8067428279694846 1.0666618413488693 0.9393175146868776 1.017953978299724 0.9057418954248007 0.882223690859013 1.0 14.895841805788372 -6.240640068244819 24.986016631420092 0.9649355156635633 0.8432790196512167 0.5722687781920046 0.05488944101645335 652.5949469364695 783956.0525200557 0.016431056198153705 0.021190195448732095 5.74592471938538e-07 6.240640068244819 -0.12165649601234663 DLSS(ph)SPPGPYGQEMYAFR ddPTM_A459_Selumetinib_30min_R1 4 DLSSSPPGPYGQEMYAFR 18 0 O43741;O43741-2 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 DLS(0.083)S(0.833)S(0.083)PPGPYGQEMYAFR;DLS(0.09)S(0.82)S(0.09)PPGPYGQEMYAFR;DLS(0.006)S(0.497)S(0.497)PPGPYGQEMYAFR;DLS(0.01)S(0.495)S(0.495)PPGPYGQEMYAFR 234.36 2.3374000000000003e-19 127920000.0 13494.4 15623.5 16191.5 17202.3 17724.7 12186.5 15766.6 14453.0 7564.4 12469.0 True False 13808.793264468453 13794.2933568319 13992.78323354316 14198.241232163764 16121.504014549946 12063.914874456694 14577.312668237508 14069.659490039607 12836.234318083138 14069.51760834525 0.9814688498117271 0.9804382595640592 0.9945460550291664 1.0091491142341769 1.1458462516858128 0.8574504976134402 1.0360918600074152 1.0000100843325483 0.9123435980825243 1.0 13.780285244301677 -8.07247002143874 20.78963008513835 0.9561717180407591 1.001375156370635 0.062268192857557914 0.06897460578096684 85.14334158100637 24420.86160285058 0.04521346586605998 0.017089139764574653 8.463109861051076e-09 8.07247002143874 0.045203438329875945 DLSSS(ph)PPGPYGQEMYAFR ddPTM_A459_Selumetinib_30min_R1 1 DLSSSPPGPYGQEMYAFR 18 0 O43741;O43741-2 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 DLS(0.019)S(0.125)S(0.856)PPGPYGQEMYAFR 105.58 0.006530199999999999 10659000.0 2340.6 2240.7 2696.5 2606.0 2470.6 2257.6 2204.4 2288.7 1163.2 1963.2 True False 2395.131425985213 1978.3578023268312 2330.3301108142623 2150.911020678559 2247.1346662198575 2234.8905937367917 2038.1203332273772 2227.9962412546624 1973.8654432333453 2215.1958431873754 1.0812278441886807 0.8930848296827041 1.0519747578892273 0.9709800726168215 1.0144180583990834 1.0088907491452666 0.9200632709272287 1.0057784498407458 0.891056855900024 1.0 11.11321853626641 -7.23858126545025 24.33204496743592 0.9547061754849672 0.999644851083016 0.15259488759897832 0.05637900498055553 1130.4835559922672 1203380.079471228 0.019865239206953652 0.01537670581883461 5.773228336028428e-08 7.23858126545025 0.04493867559804887 DLSSS(ph)PPGPYGQEMYAFR ddPTM_A459_Selumetinib_30min_R2 8 DLSSSPPGPYGQEMYAFR 18 0 O43741;O43741-2 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 DLSS(0.04)S(0.96)PPGPYGQEMYAFR;DLS(0.004)S(0.258)S(0.738)PPGPYGQEMYAFR;DLS(0.012)S(0.046)S(0.883)PPGPY(0.044)GQEMY(0.015)AFR;DLS(0.012)S(0.049)S(0.938)PPGPYGQEMY(0.001)AFR;DLS(0.022)S(0.111)S(0.594)PPGPY(0.257)GQEMY(0.015)AFR;DLS(0.07)S(0.113)S(0.805)PPGPY(0.012)GQEMYAFR;DLS(0.026)S(0.143)S(0.822)PPGPY(0.008)GQEMY(0.001)AFR;DLS(0.028)S(0.145)S(0.794)PPGPY(0.032)GQEMYAFR 195.92 2.7958e-10 81549300.0 261804.0 224636.0 275636.0 274142.0 278391.0 196607.0 222971.0 241882.0 194853.0 243918.0 True False 247253.98176444942 241864.85888141624 257901.8798497859 236803.38667867225 243417.03373288282 223687.82962935106 233339.5933086549 242585.83657427938 233829.04464770973 236875.4535649265 1.0438142831742514 1.0210634121915134 1.0887657457470417 0.9996957604295015 1.027616116695533 0.9443267601724686 0.985072914043825 1.0241071116631666 0.9871391954237176 1.0 17.85376918017012 -5.890088823392404 9.072617303071427 0.9947981633714926 1.0481118876411673 0.4800886175168635 0.02658671494146102 0.24615132830796313 18.87340614687696 0.007614183111508779 0.011316836960836489 1.287986101431757e-06 5.890088823392404 0.05331372426967462 DLST(ph)PGLEK ddPTM_A459_Selumetinib_30min_R1 3 DLSTPGLEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DLS(0.067)T(0.933)PGLEK;DLS(0.076)T(0.924)PGLEK;DLS(0.062)T(0.938)PGLEK 166.66 0.002089 231530000.0 41724.0 45131.0 43024.0 42717.0 40612.0 35964.0 40441.0 38376.0 25441.1 36210.0 True False 42696.088019228846 39847.04153916731 37181.577113915366 35257.27784740062 36938.651770630975 35602.23481269935 37390.50281076411 37358.14381718399 43171.68855557416 40857.90621526839 1.0449896231656026 0.9752590191289996 0.9100215982193625 0.8629242443712193 0.9040759841194992 0.8713670892757344 0.9151350686881617 0.9143430801459778 1.0566299782498674 1.0 15.318327653854409 -8.254296692296254 24.785248476081573 1.028314992203305 0.9211043342679383 0.3938743574759027 0.05122170322383042 467.58421295852446 1622540.959511281 0.03909788434772925 0.014092793341899432 5.56805232320331e-09 8.254296692296254 -0.10721065793536677 DLST(ph)PGLEK ddPTM_A459_Selumetinib_30min_R2 2 DLSTPGLEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DLS(0.025)T(0.975)PGLEK;DLS(0.025)T(0.975)PGLEK 113.69 0.020979 17730700.0 378443.0 322898.0 371377.0 412934.0 410356.0 422979.0 360478.0 369892.0 241611.0 390298.0 True False 357410.6530873608 347663.2383192865 347483.0081447042 356691.67684911855 358803.4106508145 481240.5178289338 377240.9412736064 370968.3244810826 289939.9511753888 379029.0826240122 0.9429636655135079 0.9172468664209604 0.9167713615511638 0.9410667761422101 0.9466382056142613 1.2696664712304224 0.9952823109561236 0.9787331407734597 0.7649543648950081 1.0 18.531949024014494 -6.54638001962343 24.99985795513562 1.012012658221572 0.9297416282529125 0.0817443449422075 0.11383428769935955 583.7347254674622 620952.7330179292 0.03941120974401065 0.03941321446332913 2.8419732143456643e-07 6.54638001962343 -0.08227102996865954 DLSYCLSGMYDHR ddPTM_A459_Selumetinib_30min_R1 2 DLSYCLSGMYDHR 13 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 ; 117.27 0.0051273 20154900.0 6654.9 7334.0 8125.2 8070.299999999999 7927.5 7220.400000000001 7408.0 6582.4 4213.799999999999 5168.4 False True 6809.946221818761 6475.331870515904 7021.84246852885 6660.973603293237 7210.459024713803 7147.769331598664 6849.20859578498 6407.8133693514665 7150.510836224783 5831.814484479238 1.1677233972278642 1.1103459974162964 1.2040579286629824 1.1421785828442792 1.2364006166354713 1.2256510131832385 1.174455842862188 1.0987683827057924 1.226121107805318 1.0 12.509729111566521 -10.538388148647279 5.139103223053308 0.9999984739675727 1.1749696168340182 0.5717549894802862 0.04573383914416529 8.094816202931287e-07 1.5506342738959397e-07 0.044826246874164345 0.010871867034469098 2.8947552573452634e-11 10.538388148647279 0.17497114286644555 DLTDYLMK ddPTM_A459_Selumetinib_30min_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 ; 141.47 0.03153 163200000.0 13072.3 11515.1 10520.400000000001 11634.2 17001.1 12333.8 11275.2 10980.7 8403.3 12626.5 False True 13376.859155732078 10166.90673877524 9091.787464420679 9602.505370981771 15463.353506787997 12209.733170194393 10424.702586284406 10689.456165659589 14259.786347251344 14247.23426752517 0.938909187885188 0.7136056407768533 0.6381440280759823 0.673990838549592 1.085358267887461 0.8569897104889325 0.731700089332162 0.7502828945562366 1.0008810186939079 1.0 13.798394264034615 -6.179232433543542 24.999999999969482 0.8807522787648465 0.7318354727765208 0.2663765929544969 0.12870684805339427 149.82582040479875 45561.86520719319 0.039518948861021384 0.05101874061538447 6.618621815698625e-07 6.179232433543542 -0.14891680598832568 DLTDYLMK ddPTM_A459_Selumetinib_30min_R2 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 ; 141.47 0.03153 118006000.0 281380.0 249860.0 273160.0 294220.0 324360.0 217480.0 279800.0 263850.0 230040.0 259140.0 False True 265742.02605338645 269023.4585734729 255585.18299412052 254146.72844219094 283610.9969848086 247435.89591312263 292811.2544131821 264617.75981728116 276054.4278546354 251657.95487342094 1.0559651340528835 1.0690043901405242 1.0156054201532192 1.0098895088375879 1.126970125492196 0.9832230260218798 1.1635287053034364 1.0514976963489144 1.0969429835567304 1.0 17.941104676384676 -6.229458182014059 24.929294208342434 1.0732368848173421 1.0382859483252556 0.08230636697320082 0.05302596145033713 1619.4769996326352 1262377.6964083952 0.01485139602963955 0.019171256917135 5.895787445578454e-07 6.229458182014059 -0.03495093649208658 DLTNNNIPHLLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DLTNNNIPHLLSPK 14 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 DLTNNNIPHLLS(1)PK 114.99 0.0018938 21518000.0 2802.3 3585.7 3826.3 4151.5 3695.9 3724.9 5944.9 7016.4 5301.9 3359.0 True False 2867.5881376734005 3165.8845770532957 3306.7094763614355 3426.518458306616 3361.6064975641443 3687.4308879385967 5496.471406733551 6830.3022795207835 8996.937064545104 3790.1603694307223 0.7565875472715443 0.8352904015849884 0.8724457949145037 0.9040563259388613 0.8869298842014576 0.9728957427974069 1.450194944537166 1.802114320705297 2.373761579354077 1.0 11.888043177725367 -7.392702085359248 2.2066047185151025 1.812483932174632 0.8571690151068537 0.6046438619381631 0.3153174273079582 0.19390719715706764 1.8447112880735126 0.1582110576999809 0.0926458637724169 4.048535153740189e-08 7.392702085359248 -0.9553149170677783 DLTNNNIPHLLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DLTNNNIPHLLSPK 14 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 DLTNNNIPHLLS(1)PK;DLTNNNIPHLLS(1)PK 144.3 0.00035118 17890200.0 75334.0 63436.0 73174.0 76992.0 69261.0 49097.0 82623.0 97298.0 82837.0 131971.0 True False 71147.23786589601 68301.33722111111 68466.0645058274 66505.55678139195 60559.81397880385 55859.66609180874 86465.13321436847 97581.12107144907 99406.71465916545 128160.6543281633 0.5551410316907331 0.5329353035778149 0.5342206222708241 0.5189233554558823 0.4725304680774857 0.435856592529378 0.6746620768100101 0.7613968700689259 0.7756414414413677 1.0 16.96759389303879 -8.085401731946726 0.9626323928670928 0.9737304097488412 0.508371647997712 0.8932025883866805 0.05431617171764691 0.16554392040243515 0.29684212729061266 0.05422649604718082 0.019877862912516548 8.214824090871489e-09 8.085401731946726 -0.4653587617511292 DLTQMADELRR ddPTM_A459_Selumetinib_30min_R1 4 DLTQMADELRR 11 1 P41227;P41227-2;C9JN83 P41227 NAA10 N-alpha-acetyltransferase 10 0 ;;; 169.65 0.0020312 66358800.0 13886.199999999999 14977.5 19146.300000000003 19775.3 17568.2 14858.0 15040.2 13936.2 8602.4 12101.6 False True 14209.721442158363 13223.927337149156 16546.337623097752 16321.915083355614 15979.159411917624 14708.54200998462 13905.705605065516 13566.566704842595 14597.6445055627 13654.95823956619 1.040627235386536 0.9684341105366334 1.2117457507232494 1.195310508974076 1.1702093211546338 1.0771575974041134 1.0183631001355073 0.9935267810290717 1.069036188134579 1.0 13.737137281520617 -7.0844780116926005 3.878148426350026 1.0203995325300759 1.1190592824645131 0.2949096231286681 0.07039659489338587 0.3459042519181685 9.64950388977995 0.03119663060282503 0.024194935496057363 8.232315160358207e-08 7.0844780116926005 0.09865974993443727 DLTQMADELRR ddPTM_A459_Selumetinib_30min_R2 3 DLTQMADELRR 11 1 P41227;P41227-2;C9JN83 P41227 NAA10 N-alpha-acetyltransferase 10 0 ;; 146.71 0.003376 3930700.0 37573.3 40756.0 43339.0 43950.0 49435.0 35974.5 30756.4 33631.5 26833.2 41913.0 False True 35485.12640383719 43881.85414880511 40550.6159239354 37963.93418202115 43224.53334549268 40929.660831003406 32186.6335426504 33729.36209700544 32200.58978225094 40702.8627869479 0.8718091056537706 1.0781024022437216 0.9962595539333582 0.9327091900325734 1.0619531498741017 1.0055720415844616 0.7907707551462847 0.8286729676375825 0.7911136361783533 1.0 15.312842647831774 -7.252801749589393 24.65150817874788 0.8383620865223711 0.9958291268887105 0.4234601415864043 0.07830678775053604 434.0571534339647 1238786.8611866718 0.028673932808241768 0.02184646322859228 5.58725188121231e-08 7.252801749589393 0.1574670403663394 DLTSLETTSEMEAGS(ph)PENKK ddPTM_A459_Selumetinib_30min_R1 1 DLTSLETTSEMEAGSPENKK 20 1 Q5VYS8-5;Q5VYS8-3;Q5VYS8-2;Q5VYS8-4;Q5VYS8-6;Q5VYS8 Q5VYS8-5 ZCCHC6 Terminal uridylyltransferase 7 1 DLTSLET(0.001)T(0.04)S(0.009)EMEAGS(0.95)PENKK 97.825 0.00046917 13866000.0 2329.2 3264.5 3842.4 3294.3 2975.4 2871.9 2551.8 2799.1 1853.1 2643.9 True False 2383.465828165753 2882.2908223751247 3320.6231847924055 2719.012346669755 2706.275595349537 2843.011293476566 2359.3156715340324 2724.8587752418107 3144.5753549309766 2983.270318766863 0.7989439686950529 0.96615140915776 1.1130815615009328 0.9114200377904945 0.9071506454930233 0.9529848085143444 0.7908487731374129 0.9133797759125405 1.054069869280498 1.0 11.542678993101283 -8.255545318052798 24.343808800512747 1.027034936283232 0.9234506695324556 0.20017150455688681 0.08585703428220953 540.5852104824222 2232773.5769516844 0.06479511826753269 0.023024291196370658 5.552066790166399e-09 8.255545318052798 -0.10358426675077648 DLTSLETTSEMEAGS(ph)PENKK ddPTM_A459_Selumetinib_30min_R2 4 DLTSLETTSEMEAGSPENKK 20 1 Q5VYS8-5;Q5VYS8-3;Q5VYS8-2;Q5VYS8-4;Q5VYS8-6;Q5VYS8 Q5VYS8-5 ZCCHC6 Terminal uridylyltransferase 7 1 DLTSLET(0.004)T(0.034)S(0.034)EMEAGS(0.928)PENKK;DLTSLET(0.006)T(0.196)S(0.057)EMEAGS(0.741)PENKK;DLTSLETTSEMEAGS(0.999)PENKK;DLTSLETTSEMEAGS(1)PENKK 109.84 0.00020017 22675900.0 75433.0 71770.8 74925.0 86230.0 66126.8 56202.7 62460.1 61901.5 50219.200000000004 67048.2 True False 71240.73584222441 77275.38958050481 70104.40707217208 74485.32524495292 57819.36020290735 63944.1117676864 65364.618412340154 62081.62311665503 60264.44324168629 65112.34425385531 1.0941202725626982 1.1868009125770236 1.0766684547380765 1.1439509066753135 0.8879938338187517 0.9820582026410493 1.0038744444141237 0.9534539698742173 0.9255455925028843 1.0 15.990643460660243 -6.249679191214743 24.996940615807038 0.959908237125902 1.1262922255080146 0.7881401744344474 0.042303449566075194 330.21403070093436 701888.2887918958 0.012251410713763237 0.015685458322498413 5.627568742996523e-07 6.249679191214743 0.16638398838211255 DLTTAGAVTQCYR ddPTM_A459_Selumetinib_30min_R2 1 DLTTAGAVTQCYR 13 0 M0R0P7;M0R3D6;M0R1A7;M0R117;Q02543 M0R0P7 RPL18A 60S ribosomal protein L18a 0 169.21 5.3591e-06 0.0 9826.6 10144.0 9799.3 9112.3 12403.0 8567.8 8590.2 9235.5 8686.0 7810.2 False True 9280.476910996536 10922.012181899081 9168.82370667113 7871.189020405723 10844.824255773157 9747.936679255334 8989.661321158379 9262.373775980668 10423.442707117738 7584.699232663386 1.2235787638131135 1.4400059708186725 1.2088579158400556 1.0377720696568393 1.4298291762275945 1.2852107091176403 1.185236361442593 1.2211919671240756 1.3742723854136956 1.0 12.888876256940826 -10.670738820550605 4.522704836105733 0.9999650304283566 1.2654697096314649 0.3227328550084818 0.1161501358130844 83300907.83348319 2.7764100688325284 32232.755110677786 0.02821310573982143 2.1343280863657004e-11 10.670738820550605 0.2655046792031083 DLVDS(ph)VDDAEGLYVAVER ddPTM_A459_Selumetinib_30min_R1 3 DLVDSVDDAEGLYVAVER 18 0 Q6ZNE5 Q6ZNE5 ATG14 Beclin 1-associated autophagy-related key regulator 1 DLVDS(1)VDDAEGLYVAVER;DLVDS(1)VDDAEGLYVAVER;DLVDS(1)VDDAEGLYVAVER 133.86 0.00057985 0.0 426.21999999999997 687.57 715.6 744.93 558.12 410.91999999999996 909.47 630.73 187.465 331.53 True False 436.1500967202505 607.068984757379 618.4254505094331 614.8419595679504 507.63814454408924 406.78651788550815 840.8679456815021 614.00099150022 318.11441309812494 374.0851048756678 1.1659114223893272 1.622809828151662 1.6531678017893148 1.6435884550182809 1.3570124496478135 1.0874170411588804 2.2477985215716507 1.6413403888515996 0.8503797904593248 1.0 8.547222712333276 -8.261670197611576 24.999308644362 0.9251898242377148 1.562297736347603 0.4031421299698267 0.30506643941328415 20.701772239379697 2241437.0406139893 0.24644510645574286 0.07884998864770934 5.47431523524742e-09 8.261670197611576 0.6371079121098882 DLVLPTQALPAS(ph)PALK ddPTM_A459_Selumetinib_30min_R1 2 DLVLPTQALPASPALK 16 0 J3KSZ6;U3KQ35;H3BR06;Q15554 J3KSZ6 TERF2 Telomeric repeat-binding factor 2 1 DLVLPTQALPAS(1)PALK;DLVLPTQALPAS(1)PALK 238.19 2.4819e-21 402670000.0 16850.5 20461.0 22166.2 24037.4 19636.5 17660.0 19178.2 17748.9 9911.0 15306.9 True False 17243.083864634653 18065.416607939165 19156.151790221054 19839.71932788134 17860.382042105648 17482.35643399707 17731.572933542604 17278.141515447594 16818.243129200207 17271.689716832145 0.9983437722268937 1.0459553699794348 1.109106989778331 1.1486843298572298 1.0340842346594377 1.0121972268271828 1.0266264172324888 1.0003735476216413 0.9737462521000461 1.0 14.076121610467593 -6.509676043114861 14.732477963134507 1.006224933476253 1.077757019660677 0.4404128221863388 0.03861483642193328 3.082265173970628 3438.9138646149618 0.013443609734153995 0.014499603673469436 3.0926014621889974e-07 6.509676043114861 0.07153208618442397 DLVLPTQALPAS(ph)PALK ddPTM_A459_Selumetinib_30min_R2 2 DLVLPTQALPASPALK 16 0 J3KSZ6;U3KQ35;H3BR06;Q15554 J3KSZ6 TERF2 Telomeric repeat-binding factor 2 1 DLVLPTQALPAS(1)PALK;DLVLPTQALPAS(1)PALK 263.19 2.3515e-39 188414000.0 346480.0 345790.0 350420.0 357840.0 361260.0 261818.0 296900.0 318450.0 238111.0 313410.0 True False 327224.02866933454 372310.9811099057 327874.35870844766 309101.5746915693 315875.28909462324 297881.0529528322 310706.4382961889 319376.63677776424 285739.853377217 304361.0389630273 1.075117990739559 1.2232544033178068 1.0772546966771153 1.015575369780223 1.0378308937662506 0.9787095416934023 1.0208482641365026 1.0493348224394812 0.9388187606099205 1.0 18.215424166746388 -5.563971680251729 3.565117680211901 1.0089785582049677 1.1507140628834638 0.6231436641760064 0.04461761554699612 0.13195131393168355 3.490311490803738 0.011613490674480281 0.022742014850600796 2.729155741513278e-06 5.563971680251729 0.14173550467849605 DLVMGS(ph)SPQLK ddPTM_A459_Selumetinib_30min_R1 4 DLVMGSSPQLK 11 0 Q53LP3 Q53LP3 SOWAHC Ankyrin repeat domain-containing protein SOWAHC 1 DLVMGS(0.765)S(0.235)PQLK;DLVMGS(0.5)S(0.5)PQLK;DLVMGS(0.756)S(0.244)PQLK;DLVMGS(0.669)S(0.331)PQLK 225.79 1.0604e-06 91653400.0 21247.1 30341.199999999997 19274.9 22110.6 21163.9 20693.100000000002 24593.5 20980.4 11895.199999999999 20964.5 True False 21742.116090340256 26788.838198758804 16657.474449447003 18249.39877736584 19249.628981790032 20484.946201831513 22738.39249465956 20423.93163805624 20185.285608966034 23655.497786522912 0.9191147143277301 1.1324571750936068 0.7041692633049199 0.771465430237657 0.813748632791697 0.8659697794861989 0.961230776027641 0.863390482093014 0.8533020860996661 1.0 14.529887899587017 -9.959087440368965 15.43736999609838 0.9999917485299143 0.8754993116991504 0.10323417989528572 0.10954444934996871 0.0 0.0 0.11168118537429579 0.027086666099553403 1.0987845890904885e-10 9.959087440368965 -0.12449243683076394 DLVMGS(ph)SPQLK ddPTM_A459_Selumetinib_30min_R2 6 DLVMGSSPQLK 11 0 Q53LP3 Q53LP3 SOWAHC Ankyrin repeat domain-containing protein SOWAHC 1 DLVMGS(0.5)S(0.5)PQLK;DLVMGS(0.786)S(0.214)PQLK;DLVMGS(0.5)S(0.5)PQLK;DLVMGS(0.5)S(0.5)PQLK;DLVMGS(0.5)S(0.5)PQLK;DLVMGS(0.5)S(0.5)PQLK 201.38 1.8746e-05 112269700.0 825548.0 663866.0 755200.0 732813.0 743096.0 624780.0 757172.0 705906.0 586721.0 585381.0 True False 779667.3470904868 714782.3875343653 706611.2541995886 633002.605227065 649741.6371174725 710837.773811847 792381.9983078536 707960.0695909704 704081.5943544568 568479.5295275064 1.3714959054699996 1.2573581816190618 1.242984518346493 1.1135011418145297 1.1429464094468051 1.250419297248332 1.3938619724204395 1.2453571902217722 1.2385346486260576 1.0 19.11674887424762 -4.739224549198229 2.048519236370853 1.215613527131245 1.4265671050904412 0.20538257775406665 0.09861111511934696 1.5109059502838538 6.429054038514682 0.027117596742394445 0.6252444167829538 1.822952912405905e-05 4.739224549198229 0.21095357795919623 DLVMGS(ph)SPQLKR ddPTM_A459_Selumetinib_30min_R1 1 DLVMGSSPQLKR 12 1 Q53LP3 Q53LP3 SOWAHC Ankyrin repeat domain-containing protein SOWAHC 1 DLVMGS(0.71)S(0.29)PQLKR 126.34 0.004935 44314000.0 5121.4 4597.8 7228.6 7696.1 6498.8 5376.1 5014.6 4613.9 2836.8 3707.0 True False 5240.718655490336 4059.487438540772 6246.99582385758 6352.120608689282 5910.984687456329 5322.021315108245 4636.3446847223795 4491.52438394062 4813.842408325611 4182.829559237776 1.2529123124121115 0.9705122766896864 1.4934856262696847 1.5186180834599459 1.4131545652874915 1.2723495518373598 1.1084230469020702 1.0738004789176963 1.1508578918053793 1.0 12.030263497310024 -7.213548766781853 3.3482499153979286 1.0854261193045924 1.3301544561491874 0.3880471764561193 0.14719546909273667 0.3085195823661197 7.025354342569866 0.06934259318427953 0.049896528248238085 6.115771253083602e-08 7.213548766781853 0.24472833684459494 DLVMGSS(ph)PQLK ddPTM_A459_Selumetinib_30min_R2 1 DLVMGSSPQLK 11 0 Q53LP3 Q53LP3 SOWAHC Ankyrin repeat domain-containing protein SOWAHC 1 DLVMGS(0.46)S(0.54)PQLK 104.94 0.011983 4329700.0 62049.0 47320.0 56565.0 57844.0 56766.0 45381.0 58407.0 57561.0 44748.0 45530.0 True False 58600.5649818273 50949.29184221849 52925.66948331536 49965.54741353428 49634.54758552117 51631.8208222982 61123.04123127485 57728.492980263494 53698.85036358554 44215.43059885325 1.3253419493634229 1.1522966338258365 1.1969954553532725 1.1300477398229876 1.1225616693826446 1.1677330769597276 1.38239163123428 1.305618699137145 1.2144821307016345 1.0 15.432262318475694 DLVQPDKPAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 DLVQPDKPASPK 12 1 Q6PJT7-5;Q6PJT7;G3V411;Q6PJT7-9;Q6PJT7-2;H0YJA2;G3V4R5 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 DLVQPDKPAS(1)PK;DLVQPDKPAS(1)PK 186.77 0.00053436 90377000.0 5746.9 6137.799999999999 7870.6 7327.2 4482.8 5898.9 4758.0 5063.1 3597.2 5436.9 True False 5880.791588479201 5419.183522614193 6801.815750111155 6047.642068578641 4077.3315315026216 5839.562421772662 4399.100229312226 4928.8101407333825 6104.1856709069725 6134.779074890715 0.9585987558295181 0.8833543077035306 1.1087303498752843 0.9857962275008858 0.6646256502032644 0.9518781932463783 0.717075574459964 0.8034209676607115 0.9950131205035632 1.0 12.582795675282378 -6.098326899314007 24.999646082939865 0.8417644815548504 0.9858941655515467 0.22223803322248115 0.11635837749051044 59.87233749354655 15213.978858558607 0.03326006646220841 0.0429385731663273 7.97394251910287e-07 6.098326899314007 0.14412968399669635 DLVQPDKPAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DLVQPDKPASPK 12 1 Q6PJT7-5;Q6PJT7;G3V411;Q6PJT7-9;Q6PJT7-2;H0YJA2;G3V4R5 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 DLVQPDKPAS(1)PK;DLVQPDKPAS(1)PK 78.903 0.023683000000000003 149709000.0 174144.0 166941.0 143865.0 129793.0 115928.0 99857.0 135989.0 118811.0 79919.0 115961.0 True False 164465.7736336657 179744.83790008014 134608.88252836867 112114.96949458642 101364.08823053056 113611.39533840671 142312.75795709135 119156.7203397801 95905.03312343347 112612.90462713859 1.4604522827842155 1.5961300216455248 1.1953237772709866 0.9955783474886751 0.9001107694197847 1.0088665745242442 1.2637340136842132 1.0581089328466227 0.8516344857720801 1.0 16.78101263378057 -5.4389156205398885 3.3093074448191375 1.0211221707417835 1.5274841965194323 0.7805980231048899 0.10820889544904841 0.11584405689342044 2.4040538277821257 0.031678046157060984 0.07210184124329426 3.6398574837152157e-06 5.4389156205398885 0.5063620257776489 DLVSFPLS(ph)PAVR ddPTM_A459_Selumetinib_30min_R1 1 DLVSFPLSPAVR 12 0 J3QLB5;E9PI66;Q7KZJ0;J3QKK3;O43502-2;O43502 J3QLB5 RAD51C DNA repair protein RAD51 homolog 3 1 DLVSFPLS(1)PAVR 174.46 0.00014188 9248700.0 1573.0 1456.4 1916.6 1597.2 1643.4 1356.1 1337.2 1248.0 725.3 1075.0 True False 1609.647839474811 1285.8840109380085 1656.33624713021 1318.2790031572504 1494.754760165836 1342.4588652402845 1236.3339274141038 1214.8989859246826 1230.781126183928 1212.9867213867312 1.3270119211483222 1.0600973516576822 1.3655023735434013 1.0868041503786168 1.2322927644722912 1.106738302712445 1.019247701244974 1.001576492556955 1.0146699089804163 1.0 10.244348041967692 -7.037870799515356 2.067547577855668 1.004789141079926 1.2093679261154484 0.5477472817128801 0.087747720730604 0.24763407035434493 2.110898990455354 0.03641266164497966 0.02761154962549304 9.164931017857539e-08 7.037870799515356 0.20457878503552251 DLVSFPLS(ph)PAVR ddPTM_A459_Selumetinib_30min_R2 2 DLVSFPLSPAVR 12 0 J3QLB5;E9PI66;Q7KZJ0;J3QKK3;O43502-2;O43502 J3QLB5 RAD51C DNA repair protein RAD51 homolog 3 1 DLVSFPLS(1)PAVR;DLVSFPLS(1)PAVR 191.48 0.00014298 5907400.0 19306.2 19829.5 20460.6 22901.0 21292.0 18678.1 19495.0 17377.9 16664.9 18506.3 True False 18233.238692842024 21350.358888108032 19144.187271816885 19781.844293571474 18617.10860710489 21250.83873208982 20401.556128609656 17428.46681193378 19998.345656210713 17971.97503385807 1.0145372814335514 1.1879806670043387 1.0652244528356198 1.1007050842383057 1.0358966430807648 1.1824431478485016 1.135187206201567 0.9697580137463826 1.1127516935971193 1.0 14.133461342375087 -7.745825683202004 24.971362438588283 1.0309411126011383 1.105314364293772 0.23103951935503864 0.06305268441481206 330.53195296599336 528629.8205311549 0.028477306422197875 0.016366697191926873 1.795454140278405e-08 7.745825683202004 0.07437325169263365 DLY(ph)ATIT(ph)HS(ph)VREEKMESGK ddPTM_A459_Selumetinib_30min_R2 1 DLYATITHSVREEKMESGK 19 2 Q9NXZ1 Q9NXZ1 SAGE1 Sarcoma antigen 1 3 DLY(0.864)AT(0.408)IT(0.864)HS(0.864)VREEKMESGK 57.973 0.019558 6750700.0 5269.8 4662.8 7880.9 7358.1 6185.6 4506.4 4412.2 4524.4 4881.5 3847.6 True False 4976.92561268084 5020.421766734917 7373.85147407514 6355.914086569507 5408.509628034381 5127.115694973769 4617.376042608439 4537.565254945256 5857.936400506014 3736.509790734634 1.3319717842094367 1.3436126352951034 1.9734596955586645 1.7010296888101752 1.4474763699123123 1.3721670709086322 1.2357457363173718 1.2143860203971597 1.5677562026016496 1.0 11.867475587244556 -6.687363319339446 2.4397672284406533 1.2790773266863333 1.594528686661739 0.31750719321214327 0.21485218406136875 0.38474410459229136 4.680617170108047 0.0838714777985251 0.08117881050216645 2.0541714112043808e-07 6.687363319339446 0.31545135997540563 DLY(ph)RDVMLENYSNLISLDLES(ph)SCVTK ddPTM_A459_Selumetinib_30min_R1 1 DLYRDVMLENYSNLISLDLESSCVTK 26 1 K7ELU5;Q7Z3V5 K7ELU5 ZNF571 Zinc finger protein 571 2 DLY(0.998)RDVMLENY(0.001)S(0.001)NLIS(0.008)LDLES(0.491)S(0.491)CVT(0.008)K 68.445 0.0054083 6275700.0 1488.2 2011.3 1837.1 2080.8 1961.5 1721.8 2060.9 1479.5 639.91 1346.9 True False 1522.8721644668858 1775.8160609719978 1587.63191046797 1717.4273414535478 1784.082671330953 1704.4802552693175 1905.4446537598908 1440.2588539067046 1085.8805328227727 1519.7877349170124 1.0020295133846713 1.168463213758575 1.0446405599889004 1.130044217357319 1.1739025327957213 1.1215252078359417 1.2537570938246434 0.9476710601203461 0.7144948652201533 1.0 10.569654124668414 -7.958703261740566 6.647995140031123 0.8481467232445778 1.1268634301066096 0.6025114680772627 0.09135692078937033 0.10685883255868073 12.400003421835585 0.04833344537226088 0.02261337256615022 1.0997570083537996e-08 7.958703261740566 0.27871670686203176 DLYANT(ph)VLSGGTTMYPGIADR ddPTM_A459_Selumetinib_30min_R2 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 DLYANT(0.438)VLS(0.438)GGT(0.062)T(0.062)MYPGIADR;DLYANT(0.991)VLS(0.009)GGTTMYPGIADR 267.56 2.0023e-59 17938300.0 67419.0 57158.0 55750.0 66423.0 53071.0 47708.0 50976.0 53742.0 49652.0 52454.0 True False 63672.12187964052 61541.834808062675 52163.105696010476 57376.07281393384 46403.74651924028 54279.34394989538 53346.48500702769 53898.38032253297 59583.78739279408 50939.51672814076 1.2499553582232128 1.2081354272853715 1.0240204274885427 1.1263568345209152 0.9109577298680032 1.0655645643357583 1.0472514941932543 1.058085819898594 1.1696967545017545 1.0 15.636497652133249 -5.181003509487856 4.374405410213219 1.0504149706085015 1.239531784716352 0.5426035993141641 0.0659213229633275 0.1630879732377048 5.700140858754819 0.016788623589397315 0.04865510432611917 6.59168568551191e-06 5.181003509487856 0.18911681410785053 DLYANTVLSGGT(ph)TMYPGIADR ddPTM_A459_Selumetinib_30min_R1 3 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 DLYANT(0.067)VLS(0.067)GGT(0.433)T(0.433)MYPGIADR;DLYANTVLS(0.005)GGT(0.498)T(0.498)MYPGIADR;DLYANT(0.057)VLS(0.003)GGT(0.47)T(0.47)MYPGIADR 290.57 2.4088e-86 56318000.0 8656.300000000001 10102.5 9124.0 10562.900000000001 9433.9 8218.3 8727.8 10375.199999999999 4923.4 7205.3 True False 8857.974947772282 8919.694603475169 7885.010914544534 8718.287805190157 8580.605410690327 8135.631363619372 8069.455019207905 10100.015992600767 8354.650209091342 8130.17044056541 1.0895189728834587 1.0971104073009879 0.9698457089167953 1.0723376427252178 1.0554028938775348 1.0006716861711429 0.9925320850526619 1.2422883464049943 1.027610708799645 1.0 12.989069881880104 DLYANTVLSGGT(ph)TMYPGIADR ddPTM_A459_Selumetinib_30min_R2 1 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 DLYANTVLS(0.018)GGT(0.583)T(0.397)MY(0.002)PGIADR 106.62 0.00018687 1408500.0 5662.8 5402.9 5186.1 6487.5 6980.4 3719.6 4997.8 4837.5 3939.8 6371.4 True False 5348.084245984488 5817.28505693834 4852.431972198745 5603.891308438277 6103.459746432231 4231.941136833041 5230.207602952825 4851.576324108764 4727.870087209583 6187.441127114731 0.8643450719147862 0.9401762275273561 0.7842388917341481 0.9056880208331664 0.9864271224635214 0.6839565904373203 0.8452941200576282 0.7841006038583684 0.764107486452035 1.0 12.595127177707564 -6.750820542107882 24.999962757068005 0.8038606796118374 0.8929293678688601 0.16218747496403163 0.08961179450940372 352.06999843705745 828878.443334722 0.028346978354505607 0.02806605098472728 1.774922757754959e-07 6.750820542107882 0.08906868825702274 DLYANTVLSGGTT(ph)MYPGIADR ddPTM_A459_Selumetinib_30min_R1 1 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 DLY(0.011)ANT(0.012)VLS(0.007)GGT(0.106)T(0.864)MYPGIADR 235.85 8.082599999999999e-26 15571000.0 3413.3 4375.5 3960.9 4447.8 3806.2 3371.3 3471.3 3867.2 2214.8 2672.6 True False 3492.823248874361 3863.2144258852345 3423.031535666311 3671.075225546469 3461.92988203919 3337.387782895488 3209.457046240337 3764.6292935640467 3758.3538374081945 3015.6542433285367 1.1582306746874096 1.281053500888484 1.1350875330747898 1.2173395652594807 1.1479863415038176 1.1066878075557618 1.0642655912363117 1.2483623750608845 1.2462814149608548 1.0 11.558255312065048 -6.3185731150324 7.232575562526063 1.142791097550361 1.1993249052488064 0.1259154347404472 0.07909195019966905 0.6692949336150484 74.00866804267132 0.024994485603874603 0.028454363061189446 4.80205229162867e-07 6.3185731150324 0.056533807698445404 DLYANTVLSGGTTMYPGIADR ddPTM_A459_Selumetinib_30min_R1 6 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ;;;;; 325.94 6.819299999999998e-136 136498800.0 7003.28 6848.470000000001 6771.08 7411.91 8462.74 6897.7 6464.3 6751.4400000000005 4764.67 5464.409999999999 False True 7166.442797989286 6046.647948632676 5851.604526880117 6117.55905728228 7697.286661218094 6828.315400610505 5976.692646562214 6572.369879432162 8085.296992271858 6165.820251360802 1.1622853904000277 0.9806721088403729 0.9490391040168034 0.9921727860834297 1.2483799960790773 1.107446393544069 0.9693264485358866 1.0659360168635525 1.3113092277523701 1.0 12.590077116654973 DLYANTVLSGGTTMYPGIADR ddPTM_A459_Selumetinib_30min_R2 5 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ;;;; 237.46 9.014e-30 26700700.0 101071.0 98877.0 113986.0 123840.0 118237.0 84937.0 92018.0 93153.0 79764.0 98535.0 False True 95453.87843926997 106460.54796033482 106652.26485857331 106972.77836408417 103383.01100780867 96636.3007686816 96297.01933020793 93424.05980769073 95719.02879237164 95690.03852532431 0.9975320306095201 1.112556224252748 1.1145597441717807 1.1179092412610314 1.0803947056667598 1.0098888270706137 1.006343197413626 0.9763195965582782 1.0003029601356013 1.0 16.54608112538793 -6.782906351786451 3.4324795750675805 0.9953309783152339 1.0909393311466868 0.6276511114852701 0.0331842131508169 0.15244252844140158 3.757461471206951 0.012263561358807509 0.011278260756063627 1.6485178280148833e-07 6.782906351786451 0.09560835283145297 DLYDAGVKR ddPTM_A459_Selumetinib_30min_R2 2 DLYDAGVKR 9 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2 Annexin A2;Annexin 0 ; 107.69 0.016833 71860600.0 331846.0 313546.0 302741.0 320573.0 308229.0 197638.0 219211.0 257207.0 170002.0 256861.0 False True 313403.3278047909 337593.96999070613 283262.97365947865 276910.40438072936 269506.5174177785 224860.8405208649 229404.7458583559 257955.42978708888 204007.1502527552 249444.7555249732 1.256403756195285 1.3533817108329937 1.1355739793499877 1.1101071409497179 1.080425671209579 0.9014454525116401 0.9196615313701755 1.0341184734239226 0.8178450167188662 1.0 17.928360812022675 -5.876593026505186 0.8684233205438773 0.9318062908842196 1.3298367917748721 0.7930789353548926 0.07062047167497681 0.3075989703723162 0.4454198463050145 0.030888163134712484 0.08563500904116808 1.328638930266458e-06 5.876593026505186 0.3980305008906525 DLYDDKDGLR ddPTM_A459_Selumetinib_30min_R2 1 DLYDDKDGLR 10 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 106.88 0.032775 5344800.0 49185.0 41931.0 54848.0 50242.0 48473.0 40925.0 41898.0 43876.0 39302.0 53609.0 False True 46451.49460315519 45146.97287058461 51319.13939398714 43398.95292771577 42383.38838588183 46562.04726983876 43846.34001931199 44003.671895937165 47163.49818963173 52061.16887709038 0.8922483994322352 0.8671909187665516 0.9857469684390862 0.8336146472272843 0.8141075066129129 0.8943719143103697 0.8422081364102192 0.8452301945010895 0.9059246883407208 1.0 15.667920083036591 -11.335917511164368 9.073993511300884 1.0025294906862148 0.8742470708349683 0.3943970849218672 0.04620690264350157 0.002458383924406321 5.065260709382186e-05 0.04651593263307488 0.011090092025487823 4.6140520441822e-12 11.335917511164368 -0.12828241985124644 DLYPFTVNT(ph)SNQGSR ddPTM_A459_Selumetinib_30min_R2 2 DLYPFTVNTSNQGSR 15 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 DLYPFTVNT(0.77)S(0.23)NQGSR;DLYPFTVNT(0.684)S(0.316)NQGSR 163.9 0.00023212 9947800.0 39103.0 31544.0 36633.0 41781.0 47753.0 41762.0 53708.0 51705.0 44636.0 44360.0 True False 36929.81180171147 33963.32337005367 34276.072662994666 36090.35572375488 41753.841222763505 47514.33642230927 56205.528420383016 51855.45298977649 53564.447234044084 43079.21153887837 0.8572536609306983 0.7883924091647374 0.7956522749275715 0.8377673229043167 0.9692341092427205 1.102952786854705 1.3047018831730086 1.2037233537335679 1.2433943268832333 1.0 15.394704224618206 -6.642802028250022 1.859612071203282 1.2051154505708677 0.8131768447276887 0.8237750666921878 0.07709804923862873 0.12283626476134686 0.8716751632838857 0.029009523191539814 0.02893186947817908 2.276134763070674e-07 6.642802028250022 -0.39193860584317897 DLYPFTVNTS(ph)NQGSR ddPTM_A459_Selumetinib_30min_R1 1 DLYPFTVNTSNQGSR 15 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 DLYPFT(0.003)VNT(0.236)S(0.76)NQGS(0.001)R 130.47 0.00079405 9193800.0 2747.6 4302.1 2386.7 2513.4 2933.7 3123.4 3092.7 3280.8 1756.7 2763.6 True False 2811.6137341010726 3798.4081320079713 2062.599249204672 2074.481872361277 2668.3473529868043 3091.9814318202966 2859.4151490529453 3193.7825264596927 2980.991595708405 3118.334979743599 0.9016394173060438 1.2180885493964124 0.661442488572625 0.6652530551839073 0.8556961873307805 0.9915488399756626 0.916968564194491 1.0241948178134144 0.9559561801642982 1.0 11.606560199117508 -6.757329416681282 24.28435668458875 0.9754480433556096 0.8583968191960776 0.13812176182355662 0.14642026805354538 173.48445413291904 1025059.1171452688 0.05365114521703199 0.05177404201448102 1.7485199157671904e-07 6.757329416681282 -0.11705122415953206 DMAECSTPLPEDCS(ph)PTHSPR ddPTM_A459_Selumetinib_30min_R1 2 DMAECSTPLPEDCSPTHSPR 20 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 DMAECSTPLPEDCS(0.865)PT(0.132)HS(0.003)PR;DMAECSTPLPEDCS(0.973)PT(0.026)HSPR 123.54 0.00015726 31619000.0 2968.8999999999996 2918.4 3159.1 3486.6 3400.5 2350.25 2939.3 3038.2700000000004 1885.18 2175.94 True False 3038.069593526232 2576.712371272649 2730.1115716941717 2877.7307615878212 3092.9253754070373 2326.6086188562626 2717.586234555994 2957.6852099081593 3199.012771900477 2455.2430944504595 1.2373803638397862 1.0494734216325643 1.111951634388054 1.172075697144736 1.259722665506287 0.9476082527693706 1.1068501692148138 1.2046404759648284 1.3029311757891293 1.0 11.261650157998616 -7.7623531003117545 24.997981635156552 1.190339379607453 1.1229237777017722 0.019713639423631024 0.10947598444774084 71.67642405050694 1960711.7826821913 0.05491907261918866 0.028765272222433608 1.7284105148272977e-08 7.7623531003117545 -0.06741560190568086 DMAECSTPLPEDCS(ph)PTHSPR ddPTM_A459_Selumetinib_30min_R2 2 DMAECSTPLPEDCSPTHSPR 20 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 DMAECSTPLPEDCS(0.968)PT(0.028)HS(0.004)PR;DMAECSTPLPEDCS(0.994)PT(0.006)HSPR 230.27 6.0089999999999986e-24 49899000.0 138962.0 124152.0 146541.0 166625.0 164201.0 136478.0 132799.0 129932.0 120272.4 150186.0 True False 131239.0483489612 133674.05918840074 137112.71160177686 143930.3875558428 143572.60240443517 155276.6056760675 138974.41663622647 130310.0806085996 144330.24069163547 145849.7399499092 0.8998236705395161 0.9165190094566498 0.940095687855645 0.9868402069504849 0.9843870990359248 1.064634093481386 0.9528602291917421 0.8934543226018328 0.9895817485941655 1.0 17.154123288349894 -5.485438094473533 2.353699014180917 0.9796496293066942 0.9062856082881976 0.3547877788701831 0.04019970176082726 0.38609249435087556 4.180646976517718 0.012552181051043405 0.031181573589618494 3.2701065650806903e-06 5.485438094473533 -0.0733640210184966 DMDEPS(ph)PVPNVEEVTLPK ddPTM_A459_Selumetinib_30min_R1 7 DMDEPSPVPNVEEVTLPK 18 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK 187.04 1.9263e-10 124295900.0 36947.6 46130.899999999994 35580.799999999996 36249.7 37062.9 34683.1 42200.2 40086.4 19953.3 36391.700000000004 True False 37808.40719248538 40729.87278232643 30749.12279134435 29919.37038614411 33710.56723898648 34334.219503735185 39017.00493842408 39023.17845302177 33859.29276862784 41062.92918017629 0.9207430630822587 0.9918891222691768 0.7488292580498356 0.7286224091531227 0.820948916992038 0.8361366368454425 0.9501758816869813 0.95032622445894 0.8245708098431004 1.0 15.325548923775923 -7.252389422925121 23.421063163286885 0.9271287479614535 0.8378089866073745 0.222293013979452 0.08224509367793638 485.57304758509616 1256653.4368892857 0.03467817824666254 0.026415824752879583 5.5925590333722215e-08 7.252389422925121 -0.08931976135407904 DMDEPS(ph)PVPNVEEVTLPK ddPTM_A459_Selumetinib_30min_R2 9 DMDEPSPVPNVEEVTLPK 18 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 DMDEPS(1)PVPNVEEVTLPK;DMDEPS(0.998)PVPNVEEVT(0.002)LPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK;DMDEPS(1)PVPNVEEVTLPK 130.87 0.00091571 47264200.0 306520.4 257181.0 300977.0 313395.0 310979.1 250028.8 274221.4 283480.0 227992.5 268735.7 True False 289485.2232663817 276905.9557327474 281612.4674989804 270710.0603634702 271911.12526957213 284467.9976645345 286973.2384593956 284304.87986735936 273597.3706427055 260976.60208179822 1.1092382265581342 1.0610374781642549 1.0790717070134672 1.0372962871155065 1.0418984809387115 1.0900134165107005 1.099612900812653 1.089388388075684 1.048359770417087 1.0 17.993560941869077 -8.582655414007561 4.447651773199173 1.0000232664408042 1.0742338068082693 0.5224223283560386 0.022274359295527728 0.263726063945639 15.444344444700365 0.023092683448185203 0.006026125749687734 2.614234766421155e-09 8.582655414007561 0.0742105403674651 DMDLWEQQEEER ddPTM_A459_Selumetinib_30min_R2 1 DMDLWEQQEEER 12 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 149.33 0.0080185 2281500.0 7784.0 7743.4 8293.9 7749.8 9340.2 8561.4 8279.5 9497.2 6324.3 7275.0 False True 7351.396441820883 8337.293881044685 7760.279503715543 6694.2638708493205 8166.800573552566 9740.655137348755 8664.513155518007 9524.835279653907 7589.336715706271 7064.951847279981 1.0405444510780613 1.1800921027161082 1.0984193058163962 0.9475314220898228 1.155959835267214 1.3787291616288828 1.2264079561779122 1.3481812028656623 1.0742234171954306 1.0 12.786464012252141 -6.5217474460225695 24.999525128279256 1.2328835272403411 1.0738602741973877 0.2144408827275518 0.11957067961847649 54.996575582473874 1215358.048479438 0.037725465278079184 0.03819058485383717 3.0078249256197196e-07 6.5217474460225695 -0.1590232530429534 DMDRDVDR ddPTM_A459_Selumetinib_30min_R1 1 DMDRDVDR 8 1 H0YIQ2;P49750-3;P49750-1;P49750 H0YIQ2 YLPM1 YLP motif-containing protein 1 0 118.74 0.02316 1791000.0 829.45 1357.0 1420.1 1276.9 1243.8 924.62 1003.3 940.87 649.39 914.51 False True 848.7745711712532 1198.1218091478156 1227.25822005093 1053.9133853816018 1131.298509610726 915.3191622877894 927.6202732385356 915.915071223522 1101.9674004309682 1031.8962665817485 0.8225386588352502 1.1610874541844256 1.1893232486598058 1.0213365621263337 1.0963296856943348 0.8870263338774046 0.898947213280811 0.8876038230640906 1.067905211132643 1.0 10.011082232932894 -6.755011912606354 24.974474236967296 0.9381874204652695 1.0690885737471805 0.20290244234961674 0.10681424864172223 213.98655635652034 831461.9530921743 0.03560418023997255 0.03479059591493983 1.7578753951447808e-07 6.755011912606354 0.130901153281911 DMES(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 DMESPTK 7 0 E7EVA0;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMES(0.996)PT(0.004)K 99.688 0.021051 28633000.0 4324.3 6455.9 4174.7 4433.2 4336.5 4566.6 5311.3 4815.6 2597.9 4559.3 True False 4425.047776376939 5700.040226733516 3607.798669985646 3659.0248414705234 3944.2643406712596 4520.664150141051 4910.664364847837 4687.874644726682 4408.446556891251 5144.530566342812 0.8601460753925805 1.1079806317072016 0.7012882173524316 0.7112456217889055 0.7666908165491166 0.8787321004012889 0.9545408082469169 0.9112346761813953 0.8569191105079128 1.0 12.328823723198724 -6.998158259979622 24.286249682644662 0.9223279644241796 0.8303995672634732 0.15319854283547485 0.11150529227055218 97.63804006046868 1287478.5232643122 0.04292042255116699 0.03757625008384629 1.0042497678765155e-07 6.998158259979622 -0.09192839716070644 DMES(ph)PTKLDVTLAK ddPTM_A459_Selumetinib_30min_R1 2 DMESPTKLDVTLAK 14 1 E7EVA0;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMES(0.92)PT(0.08)KLDVTLAK;DMES(0.682)PT(0.318)KLDVTLAK 157.47 0.0026682 912450000.0 10548.0 12960.2 14909.5 14344.099999999999 11171.0 10949.099999999999 10549.6 11000.1 6776.7 10125.3 True False 10793.747877164846 11442.813758966484 12884.871792021228 11839.172207104883 10160.585022400242 10838.961994987387 9753.835178468316 10708.341614639497 11499.564949414898 11424.98088377401 0.9447497538043452 1.0015608669610818 1.127780599643767 1.036253130534259 0.8893305928266815 0.9487072324454479 0.8537287963711967 0.9372743572680898 1.0065281567120008 1.0 13.47990413092404 -6.246589174850112 24.36199785404918 0.9323208905738967 1.0328839076724867 0.3362247517590774 0.060142007153147235 629.3399863475623 1032441.1608216261 0.018404066978045485 0.023650392142919453 5.667751821069184e-07 6.246589174850112 0.10056301709859006 DMES(ph)PTKLDVTLAK ddPTM_A459_Selumetinib_30min_R2 6 DMESPTKLDVTLAK 14 1 E7EVA0;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMES(0.975)PT(0.025)KLDVTLAK;DMES(0.96)PT(0.04)KLDVTLAK;DMES(0.892)PT(0.096)KLDVT(0.012)LAK;DMES(0.994)PT(0.006)KLDVTLAK;DMES(0.97)PT(0.03)KLDVTLAK;DMES(0.956)PT(0.044)KLDVTLAK 198.85 0.00042128 1662760000.0 498591.0 630780.0 488328.0 512002.0 469073.0 338560.0 440060.0 438036.0 302931.0 473024.0 True False 470881.3082379135 679158.797722624 456909.5081313259 442266.444347286 410143.85617417446 385193.5668583172 460523.6619623475 439310.6122392363 363525.6645993423 459366.5680560511 1.0250665611792136 1.4784680578664886 0.9946511999444735 0.962774557623709 0.8928465515238136 0.8385319995932237 1.0025188901125153 0.9563399750624264 0.7913629111881418 1.0 18.809286337998913 -5.448137688989521 7.058043097709799 0.9219991724079538 1.2516921494076765 0.5434718876292506 0.11966016945251873 0.17243672926528306 13.965357899044589 0.029326004921914787 0.061253079044249564 3.5633814185218297e-06 5.448137688989521 0.32969297699972266 DMESPT(ph)KLDVTLAK ddPTM_A459_Selumetinib_30min_R1 1 DMESPTKLDVTLAK 14 1 E7EVA0;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMES(0.162)PT(0.838)KLDVTLAK 113.67 0.014587 0.0 1089.3 1524.8 1463.8 1357.8 1172.8 1187.8 1132.4 766.14 721.58 905.59 True False 1114.6785705911707 1346.2757071397116 1265.0240000778472 1120.685719062682 1066.7204470746572 1175.8518104361106 1046.9821562995303 745.8194784265511 1224.4685578819779 1021.8312976935907 1.0908636025409955 1.3175126952740976 1.2379969207570514 1.0967424090377922 1.0439300983267856 1.1507298837784325 1.0246135136619012 0.7298851386818597 1.1983079405042363 1.0 9.996941314527634 -6.456383737645919 0.890120043015738 0.9767918836080666 1.224746433920783 0.3025216423281738 0.1275628871861766 0.6691743952840874 1.1589739656392053 0.06903319531587955 0.08968462623160911 3.4963609603996177e-07 6.456383737645919 0.2479545503127164 DMGEDLECLCQIMR ddPTM_A459_Selumetinib_30min_R1 1 DMGEDLECLCQIMR 14 0 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5;H0YD77 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 136.02 0.029856 0.0 304.49 510.5 445.28 450.77 508.43 322.62 489.62 400.43 194.82 214.72 False True 311.5840245655977 450.73042267498874 384.8134217479603 372.0514815008728 462.44259627060734 319.3747357155229 452.6875692046767 389.8092956200485 330.59531091017897 242.28140354991518 1.286041850510432 1.8603591364044934 1.5882912023360491 1.5356171627271515 1.9087003356216492 1.3181974804340475 1.8684371254742766 1.6089113316521604 1.3645096407164787 1.0 7.920539863916328 -8.55641493602869 2.435433039721979 1.0023025828255985 1.6337944344388817 0.47376042432438903 0.20379856569141383 0.24842458993046174 3.51435928179567 0.18061133034127752 0.04913285863351128 2.7770587270909653e-09 8.55641493602869 0.6314918516132833 DMLGSLRDS(ph)ALFVK ddPTM_A459_Selumetinib_30min_R1 2 DMLGSLRDSALFVK 14 1 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 DMLGSLRDS(1)ALFVK;DMLGS(0.003)LRDS(0.997)ALFVK 85.176 0.013712 51140000.0 8771.9 9982.4 9670.7 11037.7 8907.5 9645.400000000001 9202.3 6416.4 5382.5 6794.799999999999 True False 8976.26820285384 8813.655967308148 8357.472057352674 9110.172898289995 8101.818197746859 9548.37603332249 8508.163102185765 6246.216228595457 9133.709377754027 7666.978766956793 1.1707699311154784 1.1495605029315217 1.0900606759694933 1.188235049972108 1.0567158777932373 1.2453896539369793 1.1097152295313917 0.8146906908775398 1.1913049005846423 1.0 12.904442469090492 -7.54225563530236 24.992098392245882 0.9942392179645677 1.1475780303841676 0.3165328074668001 0.09717603700963717 258.65768421396444 333609.7276620006 0.04184443234504577 0.024162934207581834 2.8690912745428583e-08 7.54225563530236 0.1533388124195999 DMLPSPEQTLS(ph)PLSK ddPTM_A459_Selumetinib_30min_R2 1 DMLPSPEQTLSPLSK 15 0 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 DMLPSPEQT(0.007)LS(0.988)PLS(0.004)K 99.371 0.0082785 2718700.0 11727.0 12710.0 11489.0 12196.0 10853.0 8008.6 10845.0 10131.0 7833.2 13218.0 True False 11075.260286900493 13684.816130908637 10749.81024827739 10534.883760726509 9489.549112948967 9111.711955167517 11349.31398895982 10160.479532722664 9400.058877894846 12836.361995511585 0.8628036737179205 1.0660977102152251 0.8374499139270312 0.820706346892537 0.7392709177465642 0.7098360079244849 0.8841534691003782 0.7915388749768368 0.7322992979772391 1.0 13.647948759991172 -5.442896480049188 6.306406933883746 0.8003751985491265 0.964019494933415 0.2970229103608121 0.09200313262707682 0.24452871083740202 15.606045705358966 0.02294695484976018 0.048113066615415714 3.6066460205176028e-06 5.442896480049188 0.16364429638428846 DMNQPSSSFFSIS(ph)PTSNSSATIAR ddPTM_A459_Selumetinib_30min_R2 2 DMNQPSSSFFSISPTSNSSATIAR 24 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3;E5RJ67;E5RJN7 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 DMNQPSSSFFS(0.003)IS(0.966)PT(0.018)S(0.007)NS(0.003)S(0.001)AT(0.002)IAR;DMNQPSSSFFS(0.02)IS(0.936)PT(0.029)S(0.012)NS(0.002)S(0.002)ATIAR 93.406 2.1084e-05 3065200.0 18267.9 18702.8 21140.4 18726.0 19501.6 16942.3 17734.9 16766.5 16618.2 17625.1 True False 17252.64325019779 20137.244621019527 19780.24967992717 16175.486495848209 17051.63466148397 19275.94803811335 18559.607991037654 16815.287739156494 19942.3043513037 17116.217567490636 1.0079705508631926 1.1765008560808914 1.1556437397416828 0.9450386121856041 0.9962268003574967 1.1261803586047399 1.0843288196037244 0.9824184387030866 1.1651116417905754 1.0 14.06307630211057 -8.51219928282206 0.0070936241073968065 1.3958483863609015e-07 2.102914068901547 0.029018944906899158 0.0813726948031184 12216.720933799888 57.74796514750983 8636.356942862461 8476.87449561303 3.0746856233582373e-09 8.51219928282206 2.102913929316708 DMNS(ph)PTDRHPDGYLAR ddPTM_A459_Selumetinib_30min_R2 1 DMNSPTDRHPDGYLAR 16 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 DMNS(0.804)PT(0.196)DRHPDGYLAR 54.511 0.040712 4083000.0 22882.0 27713.0 25714.0 32591.0 27038.0 20140.0 22192.0 21208.0 20371.0 29579.0 True False 21610.31004390356 29838.497988660216 24059.589235286334 28152.049577389127 23641.24471721313 22914.10218728291 23223.971972613763 21269.7117688266 24445.769213296728 28724.977414528483 0.7523177383935391 1.0387648894570944 0.8375842698876241 0.9800547158359267 0.8230204806098782 0.7977065345121367 0.8084940028836218 0.7404605219313013 0.8510283179868604 1.0 14.810018138079304 -6.374646222612737 10.411465811072937 0.8201942397435867 0.9072800082396292 0.08493008678030112 0.09577990402202735 0.7861715398855967 67.5732972760615 0.027609510433276054 0.0313018906180596 4.220401584227156e-07 6.374646222612737 0.08708576849604244 DMPAAGS(ph)LGSSSR ddPTM_A459_Selumetinib_30min_R1 1 DMPAAGSLGSSSR 13 0 H0Y9C8;H0Y9H4;A0A087WVP1;Q14517 H0Y9C8 FAT1 Protocadherin Fat 1;Protocadherin Fat 1, nuclear form 1 DMPAAGS(0.963)LGS(0.031)S(0.005)S(0.001)R 85.837 0.027272 6046000.0 1022.1 928.73 920.54 992.74 1203.4 954.75 935.72 853.07 533.69 524.79 True False 1045.9129413396086 819.9938598451362 795.5357241642728 819.3765950377715 1094.5526824775266 945.1460818436401 865.1378870475065 830.4438124381156 905.6329508246249 592.1519083874812 1.7662915993765638 1.3847694286388488 1.343465608902007 1.383727019083764 1.848432246816798 1.5961209758107766 1.4610066687168286 1.4024168472234417 1.529392944609095 1.0 9.209823516581608 -11.209006698165595 7.0268127317555376 0.9967812019827881 1.5166708474331296 0.4867036164131461 0.161268378290483 0.008522973566038277 0.0003807014791915964 0.16365249423510397 0.03955297468510071 6.180068684854966e-12 11.209006698165595 0.5198896454503416 DMPGGFLFEGLS(ph)DDEDDFHPNTR ddPTM_A459_Selumetinib_30min_R1 14 DMPGGFLFEGLSDDEDDFHPNTR 23 0 H3BUV9;Q96S82 H3BUV9 UBL7 Ubiquitin-like protein 7 1 DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(0.997)DDEDDFHPNT(0.003)R;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(1)DDEDDFHPNTR 207.42 5.3284e-24 95261500.0 15080.8 16256.48 18004.679999999997 19448.649999999998 17858.29 15453.08 16342.82 15084.23 8152.88 12857.1 True False 15432.153297871395 14353.163764167479 15559.743348627971 16052.308373875701 16243.010822637176 15297.636045474032 15110.06792972014 14684.147219915601 13834.841897204496 14507.434023759382 1.0637410635538693 0.9893661236481069 1.0725358683792863 1.1064884629208873 1.119633616533108 1.054468765490886 1.0415396620087192 1.0121808719492922 0.953638105439366 1.0 13.824504747433542 -7.77244538167319 1.9446790676904837 0.9776730570441963 1.067893697778276 0.5241915765563745 0.03447132884494381 0.3064362403188637 2.252129892805501 0.027851780493669237 0.011262405976480367 1.6887082237277964e-08 7.77244538167319 0.09022064073407976 DMPGGFLFEGLS(ph)DDEDDFHPNTR ddPTM_A459_Selumetinib_30min_R2 4 DMPGGFLFEGLSDDEDDFHPNTR 23 0 H3BUV9;Q96S82 H3BUV9 UBL7 Ubiquitin-like protein 7 1 DMPGGFLFEGLS(0.993)DDEDDFHPNT(0.007)R;DMPGGFLFEGLS(1)DDEDDFHPNTR;DMPGGFLFEGLS(0.997)DDEDDFHPNT(0.003)R;DMPGGFLFEGLS(1)DDEDDFHPNTR 118.22 7.087200000000001e-06 4537670.0 21170.569999999996 15339.02 19152.79 21822.15 23523.519999999997 14485.65 14523.67 15974.5 11604.86 19061.8 True False 19993.994471906444 16515.473511276967 17920.520343381024 18849.935524691547 20568.285114662965 16480.916799861694 15199.049433106138 16020.983150279171 13926.156266880298 18511.43630549574 1.0800887700956276 0.8921767732509117 0.9680783299381647 1.018285951106631 1.1111123294391037 0.8903099969054687 0.8210626761897342 0.8654640777670399 0.7523001477063048 1.0 14.176129218054779 -6.950455031687735 9.029957768301502 0.8494838307645153 1.004761698852631 0.4596934800924295 0.08022224705674366 0.28197827287209376 48.024643893653106 0.02786392442374449 0.024545381047899554 1.1208434760341288e-07 6.950455031687735 0.1552778680881156 DMPHPLAGSSSEEAVGGDSTPS(ph)PDLLMAR ddPTM_A459_Selumetinib_30min_R2 2 DMPHPLAGSSSEEAVGGDSTPSPDLLMAR 29 0 Q5VWJ9 Q5VWJ9 SNX30 Sorting nexin-30 1 DMPHPLAGSSSEEAVGGDS(0.144)T(0.144)PS(0.713)PDLLMAR;DMPHPLAGSSSEEAVGGDS(0.191)T(0.191)PS(0.619)PDLLMAR 92.424 8.7739e-05 0.0 11693.1 8546.8 15550.6 15662.599999999999 13219.8 9658.8 9380.7 10195.4 6885.6 10162.8 True False 11043.24431318805 9202.312077706532 14550.091326213113 13529.326860507956 11559.010537488502 10989.212026143408 9816.921137504416 10225.066926060676 8262.912399738643 9869.373557874502 1.118940756313449 0.9324109604063229 1.4742669573596183 1.3708394743771024 1.1712000229503812 1.1134660129847267 0.9946853343768475 1.0360401160317187 0.8372276468495705 1.0 13.268742799573776 -7.124051961421567 1.6993440812075573 0.9553229169532303 1.2223771646957726 0.4026118279715104 0.14275104102107952 0.4238925705559085 2.4217628446931734 0.07872573368856534 0.05399154175543701 7.515329710296044e-08 7.124051961421567 0.2670542477425423 DMQGLS(ph)LDAASQPSK ddPTM_A459_Selumetinib_30min_R1 2 DMQGLSLDAASQPSK 15 0 E9PLZ8;Q96EY5;E9PLL0;M0QZK6;E9PQA6;Q96EY5-3 E9PLZ8 MVB12A Multivesicular body subunit 12A 1 DMQGLS(0.921)LDAAS(0.079)QPSK;DMQGLS(1)LDAASQPSK 181.72 2.049e-05 21017400.0 2774.0 2842.9 3658.8 4053.2 3292.3 3053.8 2961.6000000000004 2912.2 1249.74 2436.8 True False 2838.628802735616 2510.0519463716455 3161.955056349795 3345.384707987082 2994.5120463027756 3023.0815446285533 2738.204127602161 2834.958995841234 2120.7175026018235 2749.5870164420344 1.0323836946280034 0.9128832553259771 1.1499745370638843 1.2166862470553887 1.0890770244389916 1.099467493318477 0.9958601459885409 1.0310490189576436 0.7712858294428637 1.0 11.4249992290908 -8.082499399514038 5.592520713173556 0.8854630064151351 1.071496297349301 0.37930067015577074 0.09331320343413531 0.243878000447758 12.472340379933735 0.06817893851555766 0.025183397130726485 8.269906520223261e-09 8.082499399514038 0.18603329093416587 DMQPLS(ph)PISVHER ddPTM_A459_Selumetinib_30min_R1 2 DMQPLSPISVHER 13 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 DMQPLS(0.997)PIS(0.003)VHER;DMQPLS(1)PISVHER 108.97 0.004031 64072000.0 5828.6 6986.1 6189.0 7333.6 10163.8 6583.5 7970.599999999999 5718.5 1367.84 3324.2 True False 5964.395039518676 6168.164164250225 5348.567793743542 6052.92442872152 9244.486084564636 6517.275967339731 7369.371224833127 5566.826803694149 2321.1245769191014 3750.8934504500207 1.5901264907439816 1.644451980770125 1.4259450086756895 1.6137287045557929 2.4646090875909876 1.737526286319279 1.9646975639761166 1.4841335477088153 0.6188191180532254 1.0 11.873018566405634 -8.099461121220672 4.132392566739402 0.8241355304016191 1.7755849397410002 0.6465487403228896 0.28183991319324686 0.15163033734502612 4.3861872045607475 0.2208520737468762 0.07772065600760587 7.953144602473101e-09 8.099461121220672 0.951449409339381 DMQPLS(ph)PISVHER ddPTM_A459_Selumetinib_30min_R2 4 DMQPLSPISVHER 13 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 DMQPLS(1)PISVHER;DMQPLS(1)PISVHER;DMQPLS(1)PISVHER;DMQPLS(0.999)PIS(0.001)VHER 99.021 0.0079916 75752000.0 158214.0 131673.0 235381.0 314438.0 404648.0 230248.0 159912.0 188386.0 227146.0 270077.0 True False 149421.0992608234 141771.89570457357 220236.84272345577 271611.0019641955 353812.50064098154 261962.5720167587 167348.22485961643 188934.17207101866 272581.54698951903 262279.17526568146 0.5697024901403781 0.5405381329301596 0.8397038861372125 1.035579746996921 1.3489919673667548 0.9987928769083475 0.6380538016031863 0.7203552164583163 1.0392801743157898 1.0 18.000743737877983 -5.37811321522997 3.422013576380126 0.9594595629412715 0.55166445362711 0.4455123652862065 0.1815960404798958 0.2551240360335047 5.458582084239149 0.056206777680981215 0.13294794863644 4.186844050152724e-06 5.37811321522997 -0.4077951093141615 DMS(ph)PLSETEMALGK ddPTM_A459_Selumetinib_30min_R1 9 DMSPLSETEMALGK 14 0 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMS(1)PLSETEMALGK;DMS(1)PLSETEMALGK;DMS(1)PLSETEMALGK;DMS(0.998)PLS(0.002)ETEMALGK;DMS(0.999)PLS(0.001)ETEMALGK;DMS(0.737)PLS(0.263)ETEMALGK;DMS(1)PLSETEMALGK;DMS(0.999)PLS(0.001)ETEMALGK;DMS(1)PLSETEMALGK 314.45 2.4508e-94 300505400.0 29268.0 37178.600000000006 31594.5 31576.100000000002 30802.0 29290.8 31221.100000000002 29556.399999999998 16402.89 26092.5 True False 29949.887454385742 32825.71222813779 27304.14043616585 26061.926891806685 28015.9645385348 28996.16114591851 28866.0672907482 28772.468259282276 27834.506310314464 29441.7265374728 1.0172598884873876 1.1149384254472279 0.9273960343804472 0.8852037552429414 0.9515734242989003 0.9848661935302203 0.9804475037837229 0.9772683752992981 0.9454101231083475 1.0 14.845574656719277 -5.268203453246741 24.99345829839028 0.9548519798971111 1.0660991589170419 0.5683861296419017 0.03817325918864523 341.8511700919576 1263153.1560014216 0.01038779059212313 0.02244562479959036 5.392579380219379e-06 5.268203453246741 0.11124717901993075 DMS(ph)PLSETEMALGK ddPTM_A459_Selumetinib_30min_R2 7 DMSPLSETEMALGK 14 0 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMS(0.924)PLS(0.075)ET(0.001)EMALGK;DMS(0.997)PLS(0.003)ETEMALGK;DMS(1)PLSETEMALGK;DMS(1)PLSETEMALGK;DMS(1)PLSETEMALGK;DMS(1)PLSETEMALGK;DMS(0.965)PLS(0.015)ET(0.02)EMALGK 308.84 7.453799999999998e-94 75206200.0 251229.6 220103.8 248910.9 257714.2 247522.3 201409.6 221971.1 225675.3 193295.1 227957.5 True False 237267.26458377237 236985.05371473538 232896.24368769693 222613.08137820766 216426.33579656223 229151.94418568918 232293.1959773901 226331.97776044311 231959.52111634787 221375.77467028575 1.0717851351944683 1.0705103305350274 1.0520403329342138 1.005589169410089 0.9776423645220659 1.0351265603789988 1.049316242137897 1.0223881908376788 1.0478089640197776 1.0 17.756137829911005 -5.57095112742734 4.463798667183251 1.0208726561977546 1.0694249421569473 0.5097642739270865 0.020747723876808066 0.17827033609923107 7.638284108643428 0.006214469990166532 0.011494366111142379 2.685646653219734e-06 5.57095112742734 0.0485522859591927 DMS(ph)PPFICEETDEQK ddPTM_A459_Selumetinib_30min_R1 2 DMSPPFICEETDEQK 15 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 DMS(1)PPFICEETDEQK;DMS(1)PPFICEETDEQK 213.52 5.192100000000001e-07 10377900.0 1790.94 2428.3 1604.48 1735.77 1277.21 1594.52 1815.9099999999999 1874.17 837.11 1475.97 True False 1832.6654174373916 2143.9935071139566 1386.600428777773 1432.6503539383045 1161.6865810097397 1578.4805765083229 1678.9344467024714 1824.4609234378688 1420.5145299046287 1665.4251266652764 1.1004189789708438 1.2873550859695087 0.8325804664387397 0.8602310190953689 0.6975315566036971 0.9477943806870233 1.008111634573597 1.0954926128027347 0.8529440964716087 1.0 10.701674780183325 -5.263351263267381 24.993557511370792 0.9104720866629581 1.1938870398599566 0.498782211339452 0.11308902156993211 135.66500211331365 1773540.049038994 0.03156803094645992 0.07160037006937511 5.453166231946552e-06 5.263351263267381 0.2834149531969985 DMS(ph)PPFICEETDEQK ddPTM_A459_Selumetinib_30min_R2 1 DMSPPFICEETDEQK 15 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 DMS(1)PPFICEETDEQK 103.44 0.005649899999999999 5461000.0 11800.0 7964.7 10799.0 11989.0 8979.8 7432.9 13057.0 10236.0 6982.0 10212.0 True False 11144.20323914265 8575.56687945304 10104.204097062186 10356.07751782143 7851.677243569442 8456.714505851794 13664.176371954665 10265.785065338981 8378.59509337969 9917.153026037553 1.123730087645463 0.8647206367530913 1.0188613678273926 1.044259122616287 0.7917269424959774 0.8527361112255335 1.3778325630429697 1.035154447893069 0.8448589097477504 1.0 13.275710301976252 DMSLYAS(ph)LTSEK ddPTM_A459_Selumetinib_30min_R1 1 DMSLYASLTSEK 12 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DMS(0.203)LYAS(0.436)LT(0.343)S(0.018)EK 108.97 0.0078361 5325400.0 1600.6 1904.1 2040.8 2268.4 1642.6 2479.8 2075.2 1943.9 1378.3 1570.6 True False 1637.8908657745587 1681.1670868079248 1763.6705693119761 1872.2665231416895 1494.0271200245838 2454.855463478252 1918.6659932468958 1892.3414573229093 2338.874432950927 1772.2018089395333 0.9242123879529585 0.94863185350991 0.9951860789304452 1.0564634985120762 0.843034417687788 1.3852008564121778 1.0826453192681285 1.067791178057349 1.3197562609139217 1.0 10.791327184366759 -6.7438948154061436 24.999999548372994 1.1697886646616074 0.9612703610114435 0.45489386662814224 0.11892993245903956 230.99561002327417 329154.8978133144 0.03785538168275338 0.03777283364675396 1.8034544782918628e-07 6.7438948154061436 -0.20851830365016388 DMSPLSETEMALGKDVT(ph)PPPETEVVLIK ddPTM_A459_Selumetinib_30min_R1 4 DMSPLSETEMALGKDVTPPPETEVVLIK 28 1 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMSPLSETEMALGKDVT(0.999)PPPET(0.001)EVVLIK;DMSPLSETEMALGKDVT(0.996)PPPET(0.003)EVVLIK;DMS(0.004)PLS(0.029)ET(0.027)EMALGKDVT(0.934)PPPET(0.007)EVVLIK;DMS(0.045)PLS(0.091)ET(0.085)EMALGKDVT(0.776)PPPET(0.003)EVVLIK 109.91 8.9123e-10 246566000.0 7120.1 7790.4 11507.4 12253.699999999999 9051.999999999998 8728.7 8123.3 7038.62 4726.900000000001 6477.18 True False 7285.984476697136 6878.2963463412925 9944.7582856236 10113.82132543702 8233.248198260402 8640.89720302549 7510.552940893652 6851.93293294005 8021.204060883508 7308.589146076008 0.996907109029243 0.9411250528474788 1.3606946685411856 1.3838267719382127 1.1265167645496732 1.1822934673602223 1.0276337595096694 0.9375178705480883 1.0975037590107393 1.0 12.835377219101447 -7.297639716151357 5.265148616405536 1.0084588998823116 1.1723549388241012 0.2287565907482818 0.1341141951170933 0.3278442949860322 24.51470715190013 0.06275963140409369 0.04277555227017587 5.039184782522699e-08 7.297639716151357 0.1638960389417896 DMSPLSETEMALGKDVT(ph)PPPETEVVLIK ddPTM_A459_Selumetinib_30min_R2 2 DMSPLSETEMALGKDVTPPPETEVVLIK 28 1 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DMSPLSET(0.001)EMALGKDVT(0.997)PPPET(0.002)EVVLIK;DMSPLS(0.006)ET(0.005)EMALGKDVT(0.987)PPPET(0.001)EVVLIK 84.68 4.8775e-05 19689000.0 86693.9 91534.0 85588.6 93069.0 89497.0 58275.9 48885.1 56905.2 29838.2 93434.0 True False 81875.80010117874 98554.36347180132 80081.92265782159 80392.84164701994 78253.58674666847 66302.87624905058 51158.35401398798 57070.78471083697 35806.67374896621 90736.31764931387 0.9023487201411448 1.0861622559194364 0.8825784948352172 0.8860051160300515 0.8624285046381338 0.7307203770964574 0.5638134248703978 0.6289740005915759 0.3946233953129458 1.0 16.469392491553833 -6.719683209498728 1.4762642040102978 0.6134247737554076 0.9547693722093515 0.43063024522715787 0.1517132933679171 0.330231920498489 1.498953981606545 0.06411319873963045 0.06016029598594039 1.9068511387271057e-07 6.719683209498728 0.34134459845394394 DMYLIPLGATDKIPHPLVPFDGPGR ddPTM_A459_Selumetinib_30min_R1 1 DMYLIPLGATDKIPHPLVPFDGPGR 25 1 H0Y8L0 H0Y8L0 PHF3 0 75.773 0.00084076 12567000.0 1038.8 733.25 2530.8 2715.7 1386.0 1320.0 1070.0 1082.3 903.22 792.31 False True 1063.0020188470644 647.4007491213231 2187.131260689313 2241.4539750025965 1260.636544718175 1306.7219984641065 989.2890385380583 1053.593888194138 1532.6983714212706 894.0107062529494 1.189026050149226 0.7241532395453762 2.446426251265151 2.5071891861308475 1.410091105062777 1.461640212275473 1.106574039459155 1.1785025400982574 1.7144071773426977 1.0 9.804148298325991 -6.50281122377992 24.70582836564236 1.3077876155447603 1.730515220110924 0.12728419213844355 0.525611153895118 1595.3951112891668 1964149.3414980043 0.1805830555472127 0.20206953432431002 3.1418740859143483e-07 6.50281122377992 0.42272760456616365 DNDFIYHDR ddPTM_A459_Selumetinib_30min_R1 2 DNDFIYHDR 9 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 ; 147.74 0.002257 31822000.0 25477.0 31985.0 25662.0 28900.0 27199.0 26488.0 29594.0 28033.0 15585.5 25772.0 False True 26070.564530387615 28240.181330576906 22177.24135127595 23853.157520188168 24738.855252373472 26221.554769179744 27361.7007537339 27289.473775982875 26447.45518011804 29080.087240538447 0.8965091581308782 0.9711174900194011 0.7626263693033307 0.8202574264267064 0.8507146160788274 0.9017013791013038 0.9409084824061646 0.9384247560970379 0.909469595512408 1.0 14.8277439769123 -7.019055346472708 2.869939927743555 0.942034927196588 0.8589421281562293 0.36141243032623893 0.05417812213821511 0.34783097939782953 5.779429568207422 0.023517481800829076 0.018723935432283494 9.570720942903451e-08 7.019055346472708 -0.08309279904035871 DNDFIYHDR ddPTM_A459_Selumetinib_30min_R2 2 DNDFIYHDR 9 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 ; 113.69 0.012604 36750000.0 395140.0 349330.0 413170.0 426220.0 421570.0 292440.0 362810.0 373560.0 320130.0 346610.0 False True 373179.7006707484 376122.4877270122 386587.09202548274 368168.1007294892 368608.6077163822 332720.95549399266 379681.383894376 374646.99775381247 384164.9451795538 336602.4686990678 1.1086659646705732 1.1174085834268686 1.1484974947438744 1.0937771851538083 1.0950858712980172 0.9884685539589869 1.1279815782748224 1.1130251040694463 1.141301627003242 1.0 18.360686232111334 -10.823447273466227 3.4063407652813757 0.9995754882914549 1.1025553017972818 0.3526583163545297 0.042160015600085726 9963846.773628391 12867463.476766545 41557.41521831371 0.01108552892839467 1.5015946992922184e-11 10.823447273466227 0.10297981350582686 DNEESEQPPVPGT(ph)PTLR ddPTM_A459_Selumetinib_30min_R1 3 DNEESEQPPVPGTPTLR 17 0 A0A2R8YDC1;A0A2R8Y6V8;O15439-4;O15439-3;O15439-2;O15439 A0A2R8YDC1 ABCC4 Multidrug resistance-associated protein 4 1 DNEESEQPPVPGT(0.98)PT(0.02)LR;DNEESEQPPVPGT(0.743)PT(0.257)LR;DNEESEQPPVPGT(0.917)PT(0.083)LR 261.66 5.9558e-40 19482900.0 4790.2 4089.0 6243.4 4739.6 5400.1 5291.5 5267.2 6164.400000000001 3010.0699999999997 5199.9 True False 4901.802339893349 3610.2579790754744 5395.580572541353 3911.91783331086 4911.661908465088 5238.272314297588 4869.8908633529545 6000.900087206824 5107.868943185515 5867.357816315221 0.8354360673663068 0.6153123930905521 0.9195928970852931 0.6667256294533604 0.8371164776771153 0.8927821479937104 0.8299972518825026 1.0227602057130836 0.8705569189903821 1.0 12.51849526100451 -7.084933014573866 0.7014265684633165 0.9738586816954505 0.7479536457951453 0.4181615561814298 0.09307166095290614 0.6583631439031149 0.6673632533735172 0.07136405232378025 0.05369543894273487 8.22369482141429e-08 7.084933014573866 -0.2259050359003052 DNEESEQPPVPGT(ph)PTLR ddPTM_A459_Selumetinib_30min_R2 3 DNEESEQPPVPGTPTLR 17 0 A0A2R8YDC1;A0A2R8Y6V8;O15439-4;O15439-3;O15439-2;O15439 A0A2R8YDC1 ABCC4 Multidrug resistance-associated protein 4 1 DNEESEQPPVPGT(0.995)PT(0.005)LR;DNEESEQPPVPGT(1)PTLR;DNEESEQPPVPGT(0.975)PT(0.025)LR 292.65 1.4191e-75 33562100.0 141703.0 47850.8 93550.0 99095.0 62518.3 40516.6 140774.0 91386.0 63515.2 62422.8 True False 133827.71454205335 51520.802495427495 87531.09484953879 85598.09005159025 54664.19223330669 46097.393876924856 147320.26993838896 91651.91813023336 76220.01476296605 60620.4915700878 2.2076316287756477 0.8498908728884278 1.443919252095435 1.4120322655685498 0.9017444566596001 0.7604259332610043 2.4302057954785994 1.5118966500670463 1.2573308593983026 1.0 15.887517930498028 DNFWEMGDTGPCGPCSEIHYDR ddPTM_A459_Selumetinib_30min_R1 2 DNFWEMGDTGPCGPCSEIHYDR 22 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 ; 170.27 9.2972e-12 14402600.0 2796.1 2858.1000000000004 3214.0 3587.5 3405.8 2908.8 3231.4 3196.5 1156.7399999999998 1918.09 False True 2861.243689736501 2523.472323305357 2777.5564532382864 2961.0104707154 3097.7459913428265 2879.5401129790844 2987.652896384934 3111.7184363046845 1962.9032950530768 2164.2955352787667 1.3220207883337733 1.1659555186303738 1.2833535937967595 1.3681174416570676 1.43129528331436 1.3304745428900921 1.3804274174599342 1.437751169183042 0.906947902011104 1.0 11.079681797768341 -8.26635742402743 24.99938857020029 0.9534738934939371 1.3372603710587332 0.8029791846143408 0.07656074749646706 199.5084996297401 1014122.6179365034 0.07290672736457998 0.021140160673002836 5.415550075879086e-09 8.26635742402743 0.3837864775647961 DNGNGTYSCSYVPR ddPTM_A459_Selumetinib_30min_R2 2 DNGNGTYSCSYVPR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 217.46 1.638e-07 10151100.0 4483.3 8838.7 11585.6 8537.6 9853.599999999999 9228.2 6508.2 9986.4 5745.6 9656.099999999999 False True 4234.136134071886 9516.599869100099 10840.195109447523 7374.764151818522 8615.702675698325 10499.300784741017 6810.8441957536415 10015.458770662486 6894.880545477277 9377.303303439208 0.4515302531079462 1.0148546507618883 1.1560034648204016 0.786448290428418 0.918782553672807 1.1196503349625373 0.7263116031722793 1.0680531968065092 0.7352732787206019 1.0 13.194957381164777 -4.756770601302735 24.998056708623697 0.9484806882247837 0.45152950353936033 0.5062819569173287 0.1468588137489047 114.68735478247494 613997.1432402022 0.03482026170800724 0.2739440919776421 1.7507712193319286e-05 4.756770601302735 -0.4969511846854234 DNHLHFYQDR ddPTM_A459_Selumetinib_30min_R2 1 DNHLHFYQDR 10 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 0 108.31 0.0060668 1844900.0 5255.5 4120.3 6495.7 4684.4 5266.0 4178.8 3179.7 4051.6 3995.5 4675.2 False True 4963.420349433406 4436.313761147358 6077.773733983411 4046.376638959269 4604.438001362688 4754.3917686304785 3327.56235045602 4063.389485221514 4794.711643597618 4540.214828371598 1.0932126643913886 0.9771153852511631 1.3386533377239502 0.8912302152914976 1.0141454039993356 1.0471733053071628 0.7329085684805557 0.8949773609454725 1.056053914813828 1.0 12.148544847485269 -5.821273933514604 24.999997179417598 0.9416110726969343 1.1204166502001232 0.32835612322758423 0.12250873079959707 86.42405233506977 36108.92535608469 0.03483878923488834 0.05167431028728923 1.509127963544595e-06 5.821273933514604 0.17880557750318882 DNIQGITKPAIR ddPTM_A459_Selumetinib_30min_R1 2 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 0 ; 127.52 0.007274299999999998 111413000.0 5503.2 4649.9 7568.7 7020.099999999999 5941.5 5844.3 5584.6 7622.2 2879.01 6360.200000000001 False True 5631.413852636858 4105.487546320136 6540.91211189316 5794.171318597681 5404.092374057021 5785.511648199829 5163.349125812746 7420.0344956050585 4885.46969542919 7176.593623594313 0.7846917560056063 0.5720663258433115 0.9114229472864064 0.8073706862192008 0.7530163553207356 0.8061640315231091 0.7194707401067448 1.033921507163286 0.6807504997032785 1.0 12.809083514717853 -14.522878720921067 0.08226972473184033 1.6771810847267725 0.5914829226526312 0.24000675651269943 0.11756157995605382 334.3579625688263 1.9324669427271013 40.93097412305652 3.5586024551868 3.000000168267883e-15 14.522878720921067 -1.0856981620741413 DNLAEDIMR ddPTM_A459_Selumetinib_30min_R1 4 DNLAEDIMR 9 0 P08670;B0YJC4 P08670 VIM Vimentin 0 ;;; 166.34 0.011853 56471500.0 13456.7 14552.9 12735.3 13271.7 15836.1 12429.400000000001 13279.199999999999 13187.400000000001 8399.8 11109.6 False True 13770.214927819889 12849.039702540342 11005.916209995507 10954.046735663713 14403.727551090531 12304.371520992245 12277.539252854738 12837.627313287787 14253.847102881222 12535.625376667927 1.0984864746716072 1.0250018899300997 0.8779710528427557 0.8738332876516919 1.1490234526232437 0.9815522681376466 0.9794117871220406 1.0240914934473044 1.137067092752417 1.0 13.613746350616553 -6.2534708796021965 24.999784437616213 1.039924692390414 0.9663465136943337 0.16975381789245325 0.08217259825947158 1261.5493074963301 3957889.9386237 0.025907643661024434 0.032765633166312966 5.578650069597571e-07 6.2534708796021965 -0.0735781786960803 DNLAEDIMR ddPTM_A459_Selumetinib_30min_R2 4 DNLAEDIMR 9 0 P08670;B0YJC4 P08670 VIM Vimentin 0 ;;; 174.86 0.0045359 72769000.0 363909.0 339804.0 342671.0 368718.0 392402.0 293720.0 317175.0 300334.0 258225.0 310268.0 False True 343684.3946231497 365865.87415792845 320623.9209319749 318497.97232597275 343104.9526416105 334177.26387530944 331924.265970339 301207.9222170301 309877.21540933364 301309.75666692277 1.1406348019558796 1.2142516664748033 1.0641006931826724 1.0570450019580693 1.138711724562207 1.109082120579054 1.1016047725837783 0.999662027373361 1.028434056823064 1.0 18.20088786382152 -3.5721470768868646 0.141214281893515 0.9575657851754742 1.4438616629288599 0.5459565104623065 0.04391067324506517 33.92238861532206 0.5552477930964331 0.23827534645895418 3.0969371182611787 0.0002678261159202832 3.5721470768868646 0.4862958777533857 DNLLDTYSADQGDS(ph)SEGGTLAR ddPTM_A459_Selumetinib_30min_R2 2 DNLLDTYSADQGDSSEGGTLAR 22 0 Q6ZRP7 Q6ZRP7 QSOX2 Sulfhydryl oxidase 2 1 DNLLDTYSADQGDS(0.964)S(0.036)EGGTLAR;DNLLDTYSADQGDS(0.935)S(0.065)EGGTLAR 302.59 4.293199999999998e-107 15406300.0 66522.0 15264.7 45774.0 37667.0 35610.0 35191.0 42852.0 32164.0 30367.0 36454.0 True False 62824.97354866499 16435.453406253433 42828.95067496295 32536.689620800695 31136.353442560845 40038.240817908285 44844.702909627136 32257.59191496317 36441.248524872695 35401.47830113324 1.7746426579777572 0.46425895739295486 1.209806842263758 0.9190771454241548 0.8795212781146525 1.130976522430325 1.266746617984922 0.9111933586663404 1.0293708136958273 1.0 15.111521985427881 -4.7329665988362875 24.995474340503968 0.9921930513751833 1.7746470680656985 0.5598196390314845 0.21136598732520612 2538.859352689773 2228674.992742916 0.050587399744690766 5.37463421168427 1.8494108498876878e-05 4.7329665988362875 0.7824540166905152 DNLTLWTSDQQDDDGGEGNN ddPTM_A459_Selumetinib_30min_R1 4 DNLTLWTSDQQDDDGGEGNN 20 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 ;;; 295.83 2.3683e-85 146048400.0 23580.6 27126.0 27301.3 29806.0 27551.6 22093.3 25802.7 23873.8 13590.0 20573.8 False True 24129.982100139678 23950.07530946472 23593.93341530628 24600.941627914486 25059.56264463006 21871.061461111385 23856.381565127063 23240.589270968478 23061.237425671567 23214.647635782632 1.0394291775915723 1.0316794674302319 1.0163382096284341 1.0597163486554517 1.0794720229138308 0.9421233440304186 1.0276434921353392 1.001117468401539 0.9933916632068711 1.0 14.502747762630763 -6.748554380671541 24.999840879860667 0.9950992934620636 1.043757752573724 0.5177881129715456 0.02524950851077157 208.80714887619675 405132.4058349168 0.008487899971553215 0.008436175747928033 1.784208562872407e-07 6.748554380671541 0.048658459111660446 DNLTLWTSDQQDDDGGEGNN ddPTM_A459_Selumetinib_30min_R2 4 DNLTLWTSDQQDDDGGEGNN 20 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 ;;; 255.24 1.4922e-37 60609000.0 311625.0 265048.0 321425.0 341341.0 332471.0 250875.0 268802.0 278338.0 229419.0 288230.0 False True 294306.13003371394 285376.3293363547 300744.8654410793 294849.7669539311 290703.0206515485 285430.7540334954 281301.82562105806 279147.91749866353 275309.2105024452 279908.05098852405 1.051438602763806 1.0195359809355924 1.0744416403135526 1.053380800990321 1.0385661277869676 1.0197304187052403 1.004979401727145 0.9972843457443399 0.9835701743131804 1.0 18.094593458147116 -7.019461527245136 1.4464737936918133 0.993265909804277 1.0492637783978407 0.7738089004135769 0.013193828203523349 0.1985270257448133 0.8409761314913885 0.00707767968660692 0.005136407825679539 9.561773959559997e-08 7.019461527245136 0.055997868593563704 DNLTLWTSDQQDEEAGEGN ddPTM_A459_Selumetinib_30min_R1 1 DNLTLWTSDQQDEEAGEGN 19 0 Q04917 Q04917 YWHAH 14-3-3 protein eta 0 132.31 0.0056488 0.0 1003.5 1172.6 1075.2 1078.2 1001.2 976.37 1225.0 1017.1 672.58 930.39 False True 1026.8795975289077 1035.3114468730496 929.1937456508416 889.9126103206536 910.6416367762172 966.5486042730305 1132.5972637468417 990.1232039935855 1141.3191367003813 1049.8146192660472 0.9781532650467623 0.9861850157857992 0.8851026920357283 0.8476854808354781 0.8674308969071801 0.9206850300377507 1.078854535802397 0.9431409944412915 1.0871625482776257 1.0 10.035918877812817 -7.169064842891496 7.142413306894023 1.022283043204546 0.9103567742358412 0.49658147652189844 0.05565633874340766 0.2450531603528953 16.417431248127723 0.022479888488438626 0.017379729359882974 6.775403390338942e-08 7.169064842891496 -0.11192626896870483 DNLTLWTSDQQDEEAGEGN ddPTM_A459_Selumetinib_30min_R2 2 DNLTLWTSDQQDEEAGEGN 19 0 Q04917 Q04917 YWHAH 14-3-3 protein eta 0 ; 207.08 3.2984e-15 4223400.0 50765.0 49953.0 56633.0 60648.0 63727.0 46384.0 44855.0 48148.0 43849.0 54123.0 False True 47943.68452839633 53784.234475789126 52989.2944373482 52387.63777636453 55721.044533391614 52772.97496797073 46940.846378496295 48288.10270866953 52620.025243426826 52560.328361557986 0.9121648593706614 1.0232857394994186 1.0081614040315616 0.9967144310057287 1.0601350157116853 1.0040457625178818 0.893085105092842 0.9187176757439531 1.0011357783280612 1.0 15.681686668225513 -7.1535235726826665 13.31110586446479 0.9464677688584009 1.0046757193739664 0.19283215499332818 0.046400444239861546 1.2643077232470135 150.51215248768688 0.017650976470415813 0.013672578666158428 7.02225227244807e-08 7.1535235726826665 0.05820795051556549 DNLTLWTSENQGDEGDAGEGEN ddPTM_A459_Selumetinib_30min_R1 4 DNLTLWTSENQGDEGDAGEGEN 22 0 P31946-2;P31946 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ;;; 342.28 2.2430999999999985e-182 39135700.0 45904.0 51390.6 52963.2 56002.0 52075.7 43367.3 49798.4 44879.4 26690.9 38759.1 False True 46973.47388636469 45373.7646611582 45771.08834603298 46222.301987736224 47365.46212971159 42931.06433635792 46042.066595078155 43689.05252316362 45292.50787379372 43734.20803060508 1.074067097625108 1.0374891121706324 1.0465740756984212 1.056891254447548 1.083030064167742 0.9816358011173972 1.0527701007608974 0.9989675014256607 1.0356311435226666 1.0 15.416474548293529 -6.75374073045267 24.9999942128721 1.016171951303226 1.0575060664854181 0.5139126802924204 0.02216905078745418 156.28404913373984 507504.4012344617 0.007040293020268149 0.006915828274092216 1.7630282428789555e-07 6.75374073045267 0.04133411518219221 DNLTLWTSENQGDEGDAGEGEN ddPTM_A459_Selumetinib_30min_R2 5 DNLTLWTSENQGDEGDAGEGEN 22 0 P31946-2;P31946 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ;;;; 264.31 8.867099999999997e-57 40113400.0 167634.0 155315.0 174495.0 201176.0 193997.0 142323.0 145923.0 154054.0 136351.0 165191.0 False True 158317.57337207097 167227.16108356236 163268.18167579116 173775.48175204327 169625.3625048155 161926.70137044 152708.70864093894 154502.27163498738 163625.00996525562 160421.50661223743 0.9868849677041621 1.042423579076434 1.017744971504566 1.0832430477796495 1.057372955079054 1.0093827491711622 0.9519216710142147 0.9631019861223613 1.0199692885366145 1.0 17.291508041434803 -6.995740743642855 6.124131319355958 0.9805061243215677 1.0389054769855877 0.42806539488734696 0.02921558171500212 0.1406190392351083 22.04028775367003 0.011016575933714648 0.009273554802288423 1.0098555493661344e-07 6.995740743642855 0.058399352664019966 DNPAQDFSTLYGS(ph)SPLER ddPTM_A459_Selumetinib_30min_R1 1 DNPAQDFSTLYGSSPLER 18 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 DNPAQDFSTLYGS(0.5)S(0.5)PLER 245.67 5.0948999999999996e-26 11681000.0 1594.6 1697.0 1878.7 1795.8 1985.5 1673.3 1805.8 1343.7 900.72 1502.6 True False 1631.751077448526 1498.314451086103 1623.5828589604134 1482.1972413409649 1805.9118755684967 1656.4681212348391 1669.587052142079 1308.0607110472724 1528.456054014046 1695.4733465634424 0.9624162365960661 0.8837145415013683 0.9575985740213824 0.874208517842662 1.065137284068135 0.9769944921825736 0.9847321136166296 0.7715017836750915 0.9014922334887044 1.0 10.727472389530893 DNPAQDFSTLYGSS(ph)PLER ddPTM_A459_Selumetinib_30min_R1 1 DNPAQDFSTLYGSSPLER 18 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 DNPAQDFSTLYGS(0.209)S(0.791)PLER 241.51 3.9091999999999996e-25 12619000.0 2154.5 2058.9 2770.0 2724.3 2505.1 2086.3 2597.6 2657.4 1153.0 1895.9 True False 2204.6956580727783 1817.8430308433574 2393.849214520862 2248.5521464445906 2278.5141473113263 2065.313716208837 2401.660940660241 2586.9171195482786 1956.5567882118685 2139.257232629864 1.0305893206505459 0.8497542993502558 1.119009522561258 1.051090122378769 1.0650959186008073 0.9654349578474367 1.1226611293059858 1.2092594944125024 0.9145963179970669 1.0 11.06289425287183 -5.2713717886524245 24.98989997002076 1.062677999775537 0.9401718049555547 0.20825062366804892 0.08947684880194647 849.375871089516 2137028.627185732 0.02265394923963587 0.04804381387523998 5.353381716621769e-06 5.2713717886524245 -0.12250619481998215 DNPS(ph)PEPQLDDIKR ddPTM_A459_Selumetinib_30min_R2 2 DNPSPEPQLDDIKR 14 1 Q96JC9-2;Q96JC9 Q96JC9-2 EAF1 ELL-associated factor 1 1 DNPS(1)PEPQLDDIKR;DNPS(1)PEPQLDDIKR 98.062 0.0054714 20436000.0 58104.0 43266.0 47199.0 54514.0 58403.0 50741.0 56101.0 60629.0 52773.0 49707.0 True False 54874.81228874109 46584.36307788303 44162.267726385646 47089.099158104706 51065.89301055546 57730.11216906268 58709.80766202253 60805.42035232871 63329.07460082022 48271.829755703955 1.1367874921347247 0.9650424132177933 0.9148662470406416 0.9754985339568676 1.057881859233259 1.195937930284093 1.2162333178407265 1.259646063968473 1.3119261258858135 1.0 15.558893893082509 -6.678419241809634 2.6931941634695504 1.2181737791551186 0.9907263057021569 0.5044681748475001 0.0928868702459635 0.20281505209852416 2.991739303351748 0.03324665049835776 0.03237348935135037 2.0969146707863263e-07 6.678419241809634 -0.22744747345296168 DNPS(ph)PGPSR ddPTM_A459_Selumetinib_30min_R2 2 DNPSPGPSR 9 0 Q9NQS1 Q9NQS1 AVEN Cell death regulator Aven 1 DNPS(0.997)PGPS(0.003)R;DNPS(0.997)PGPS(0.003)R 129.74 0.0040106 30012000.0 113664.0 93935.0 107917.0 126654.0 133875.0 110605.0 124742.0 146060.0 132393.0 149734.0 True False 107347.00991304331 101139.51245136921 100973.73771114567 109403.50670966369 117056.42564231477 125839.8347777767 130542.75017158382 146485.01041846527 158875.2993694953 145410.79036434638 0.7382327655607323 0.6955433788507064 0.6944033345678291 0.7523754353823291 0.8050050848978545 0.8654091932412168 0.8977514656545867 1.0073874851476103 1.09259635389789 1.0 17.149774804406334 -7.140756645599665 0.8335066198469788 1.053706656145136 0.7069170402431083 0.9389830086766379 0.033188388341616346 0.1390324910298792 0.19420830479649867 0.02607301087212526 0.01714820729046351 7.231749169709191e-08 7.140756645599665 -0.3467896159020277 DNQES(ph)SDAELSSSEYIK ddPTM_A459_Selumetinib_30min_R1 1 DNQESSDAELSSSEYIK 17 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 DNQES(0.5)S(0.5)DAELSSSEYIK 224.99 1.1382e-12 10714000.0 3555.2 4315.0 4050.9 4413.1 4285.0 3461.5 4230.7 4067.9 2368.7 3289.3 True False 3638.0292427850272 3809.7977940109226 3500.8100300009246 3642.434929146798 3897.422506578194 3426.680452790535 3911.5748928438898 3960.006077598571 4019.5108969969233 3711.5136954952295 0.9802009479853483 1.026480866454833 0.9432297216766189 0.9813879802108033 1.0500897548373882 0.9232568525746235 1.0539028584459975 1.0669517621354716 1.082984255689402 1.0 11.857791977062226 -7.407920528966544 11.58348936056899 1.0570599079428205 0.9870632928031515 0.4027211223739975 0.0395271406238384 0.5290028637548506 50.239904777719765 0.01589504980020679 0.010710851294048432 3.9091242184957744e-08 7.407920528966544 -0.06999661513966893 DNQES(ph)SDAELSSSEYIK ddPTM_A459_Selumetinib_30min_R2 1 DNQESSDAELSSSEYIK 17 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 DNQES(0.993)S(0.007)DAELSSSEYIK 343.06 7.267599999999997e-155 21871000.0 60535.0 55108.0 51648.0 55409.0 58175.0 40134.0 47490.0 54085.0 42382.0 46048.0 True False 57170.70704080509 59334.606399851546 48325.0239100906 47862.19861414361 50866.53640890131 45662.094199821826 49698.37909964978 54242.37839574622 50859.584252022105 44718.474592927654 1.2784583454876342 1.3268477277003423 1.0806500970794144 1.0703003411863503 1.1374837105232116 1.0211013370980102 1.1113612338536634 1.2129747020557986 1.137328245540506 1.0 15.448583356309431 -5.261865921730705 24.99757212514312 1.1023864369101313 1.3026530506499165 0.6625146181079117 0.05875888648457393 21.936555115431954 1285683.8885188175 0.015662764294253655 0.036237578138118176 5.47184867356875e-06 5.261865921730705 0.20026661373978527 DNQESS(ph)DAELSSSEYIK ddPTM_A459_Selumetinib_30min_R1 3 DNQESSDAELSSSEYIK 17 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 DNQES(0.009)S(0.991)DAELSSSEYIK;DNQES(0.031)S(0.969)DAELSSSEYIK;DNQES(0.004)S(0.995)DAELSSSEYIK 275.69 2.0401e-52 50863600.0 11651.9 12401.2 11217.0 11956.4 12282.3 9930.3 12098.0 11543.0 5955.200000000001 9843.3 True False 11923.366599349352 10949.261738838533 9693.793010570587 9868.439189424844 11171.36813361618 9830.410197990997 11185.438119844328 11236.84214305177 10105.539449400976 11106.7834368614 1.0735211204152826 0.9858175232353877 0.8727813111398792 0.8885055916975282 1.0058148875524515 0.8850816488746551 1.0070816797167295 1.0117098444324328 0.9098529296846216 1.0 13.439153447259422 DNQESS(ph)DAELSSSEYIK ddPTM_A459_Selumetinib_30min_R2 1 DNQESSDAELSSSEYIK 17 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 DNQES(0.027)S(0.973)DAELSSSEYIK 284.84 3.2096999999999996e-64 20445000.0 73700.0 59504.0 73673.0 66902.0 69369.0 53242.0 51250.0 68008.0 49440.0 67612.0 True False 69604.04904447567 64067.76546448373 68932.95938909723 57789.83218761273 60654.24605327157 60575.60221724511 53633.2265499484 68205.89202066949 59329.381469019165 65659.86588292717 1.0600699241235285 0.9757523047445423 1.0498492261925427 0.8801393577418073 0.9237643914993564 0.9225666455860967 0.8168342385221665 1.0387759874849871 0.9035866989860231 1.0 16.00272418260939 -5.75562541258994 24.999963428245756 0.9232892992798606 1.0232766802437907 0.36896073097223814 0.060929195471751685 151.96454355616532 653436.6123881892 0.016146992597110388 0.0270338928764586 1.755393910354343e-06 5.75562541258994 0.09998738096393012 DNQHQDEAEGDPGNRHEPR ddPTM_A459_Selumetinib_30min_R2 1 DNQHQDEAEGDPGNRHEPR 19 1 F8W785;O00461 F8W785 GOLIM4 Golgi integral membrane protein 4 0 54.368 0.025453 1084600.0 5458.3 847.48 3963.6 3351.8 3957.9 4409.6 3416.9 2983.0 3496.2 3378.3 False True 5154.949537306127 912.4789909223016 3708.5862912413854 2895.279057822494 3460.673217925063 5016.98237363668 3575.7926204589044 2991.6800361377673 4195.537691989988 3280.7597011224707 1.5712670256045957 0.27813039480157853 1.1304047321638764 0.8825026279224019 1.054838980355994 1.529213606202302 1.0899282319383197 0.9118863643424423 1.2788311471134377 1.0 11.679814212351145 -6.521564571771922 24.998725656679817 1.1675247149027554 0.9332994136585167 0.06800514196306895 0.3347125070380095 121.53495921947184 2311952.822125358 0.10496585846217316 0.10632840978326584 3.0090917378354283e-07 6.521564571771922 -0.2342253012442388 DNS(ph)PEPNDPEEPQEVSSTPSDKK ddPTM_A459_Selumetinib_30min_R2 4 DNSPEPNDPEEPQEVSSTPSDKK 23 1 Q9HB58-7;G5E9C0;Q9HB58-2;Q9HB58-5;Q9HB58-3;Q9HB58;Q9HB58-6 Q9HB58-7 SP110 Sp110 nuclear body protein 1 DNS(1)PEPNDPEEPQEVSSTPSDKK;DNS(1)PEPNDPEEPQEVSSTPSDKK;DNS(1)PEPNDPEEPQEVSSTPSDKK;DNS(1)PEPNDPEEPQEVSSTPSDKK 144.23 3.1226e-07 54973800.0 218728.0 159448.0 172142.0 167634.0 146511.0 123764.0 180840.0 155847.0 94250.1 157258.0 True False 206571.9733975585 171677.14889387225 161066.5711340386 144801.9600152201 128104.9783550416 140811.36758226808 189249.41832766176 156300.48896814027 113102.7535678235 152717.55293464672 1.3526406718025268 1.1241481126098125 1.0546696698510138 0.9481684143877425 0.8388359811518344 0.9220378723755892 1.2392119615002495 1.0234611933248223 0.7406008765490382 1.0 17.22050636549367 -4.737172838063067 1.327435124409127 0.9675457749734145 1.5435779075970373 0.4883262454215058 0.12319470083650108 1.3819049319184231 2.0024339991883413 0.03863974727272575 1.1142308608814098 1.831585353319529e-05 4.737172838063067 0.5760321326236227 DNS(ph)PSLK ddPTM_A459_Selumetinib_30min_R1 1 DNSPSLK 7 0 A0A087WU05;A0A087WY48;Q8IY22-3;Q8IY22-2;Q8IY22 A0A087WU05 CMIP C-Maf-inducing protein 1 DNS(0.977)PS(0.023)LK 87.258 0.033827 8841000.0 4822.0 6721.2 5205.7 4883.5 4806.7 5804.2 4894.5 5661.8 3976.8 5724.3 True False 4934.343218021321 5934.278779398894 4498.79453286327 4030.6883996484044 4371.93483369181 5745.815017791942 4525.303924415444 5511.630671881702 6748.339146019918 6459.069664403782 0.7639402382071686 0.9187513198848073 0.6965081299024108 0.6240354430393755 0.6768675770422072 0.8895731608930281 0.7006123419529896 0.8533164926609389 1.0447850072294953 1.0 12.65711066518377 -8.088239201350373 3.3980687912936696 1.0207660905236284 0.754776362711179 0.5971946608692824 0.08749833448497159 0.18584334932392518 3.9034580065899442 0.07209515302005834 0.024606162368477943 8.161327367615197e-09 8.088239201350373 -0.26598972781244945 DNS(ph)PSLK ddPTM_A459_Selumetinib_30min_R2 1 DNSPSLK 7 0 A0A087WU05;A0A087WY48;Q8IY22-3;Q8IY22-2;Q8IY22 A0A087WU05 CMIP C-Maf-inducing protein 1 DNS(0.992)PS(0.008)LK 81.95 0.042069 8713400.0 128510.0 95120.0 94897.0 109990.0 100380.0 80389.0 159150.0 180290.0 118270.0 135610.0 True False 121367.92866629006 102415.39814099373 88791.43033604158 95009.17225666682 87769.36699141422 91461.85505131504 166550.7903497424 180814.614051384 141927.30473990506 131694.58694290541 0.9215863118117956 0.7776735590916479 0.6742223230066094 0.7214356676471212 0.6664614623034245 0.6944997298253968 1.2646745338283985 1.3729844046648172 1.077700367452733 1.0 17.006836521996924 -7.260517635201644 24.9991177442128 1.2099218762188246 0.7367013605155747 0.7665183421823736 0.1174093047781996 36.92772455586971 1001555.4726333909 0.046764886511421584 0.0340982084774719 5.488862667755481e-08 7.260517635201644 -0.47322051570324997 DNS(ph)TMGYMAAK ddPTM_A459_Selumetinib_30min_R2 1 DNSTMGYMAAK 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DNS(0.909)T(0.091)MGYMAAK 89.74700000000001 0.028801 3113200.0 11722.0 11105.0 12891.0 11507.0 10662.0 7693.3 8349.8 12479.0 7246.8 11042.0 True False 11070.538166883915 11956.717791797048 12061.607094659565 9939.726749317808 9322.544240510631 8752.982242175944 8738.082244814821 12515.311823990342 8696.362492509876 10723.18876943856 1.0323923606040875 1.1150337878853802 1.1248153281639077 0.9269375894646521 0.8693817148011223 0.8162667309487482 0.8148772191457304 1.1671259448177758 0.8109866085072375 1.0 13.388446365361071 -5.794136082712553 7.769584019585946 0.9114056882454383 1.0931718339676932 0.3728701094952568 0.10433029522143987 0.2119727344737015 41.46104493779705 0.029720502163879947 0.044975047320557834 1.6064378096651553e-06 5.794136082712553 0.1817661457222549 DNSPS(ph)LK ddPTM_A459_Selumetinib_30min_R1 1 DNSPSLK 7 0 A0A087WU05;A0A087WY48;Q8IY22-3;Q8IY22-2;Q8IY22 A0A087WU05 CMIP C-Maf-inducing protein 1 DNS(0.099)PS(0.901)LK 94.409 0.024453 34550000.0 7844.7 11097.0 8540.2 7956.6 7911.3 9033.8 7792.4 9655.1 7359.6 9757.4 True False 8027.466246870973 9797.758081144662 7380.487747960679 6567.129173879902 7195.72431185346 8942.928174034127 7204.612994302766 9399.015383815222 12488.70367608332 11009.857335124541 0.7291162821212132 0.8899078146895745 0.6703527142368001 0.5964772270871225 0.6535710766112359 0.8122655818167299 0.6543784151787349 0.8536909332902725 1.134320209240209 1.0 13.426508154242663 -8.052983621520236 3.8997334997993867 1.060923388092696 0.7177547809258601 0.7245550679562406 0.08604379856312104 0.12566748220730375 3.8058239288842315 0.06560632664764385 0.02378909901240019 8.851489906866167e-09 8.052983621520236 -0.34316860716683595 DNSPS(ph)LK ddPTM_A459_Selumetinib_30min_R2 2 DNSPSLK 7 0 A0A087WU05;A0A087WY48;Q8IY22-3;Q8IY22-2;Q8IY22 A0A087WU05 CMIP C-Maf-inducing protein 1 DNS(0.092)PS(0.908)LK;DNS(0.09)PS(0.91)LK 93.598 0.025499 65331000.0 349770.0 225914.0 226150.0 289070.0 255930.0 202206.0 423440.0 511430.0 287160.0 342540.0 True False 330331.18364024785 243240.87737199842 211599.7552135031 249698.167326436 223777.78535677018 230058.04105668934 443130.7990304416 512918.17662820604 344600.02392078424 332649.98017419665 0.9930293200897395 0.7312216800512721 0.6361033152705917 0.7506333449822489 0.6727124566175712 0.6915919277560646 1.3321233291473222 1.541915548468121 1.035923777119511 1.0 18.343645422172827 -7.260534185339024 24.99976062032075 1.2726503113879053 0.7371157569721318 0.6550925208368764 0.16986801324635703 45.358945827517545 1252754.7046245278 0.06627603965496368 0.04830603121709678 5.4886535016156394e-08 7.260534185339024 -0.5355345544157735 DNST(ph)MGYMAAK ddPTM_A459_Selumetinib_30min_R2 1 DNSTMGYMAAK 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 DNS(0.339)T(0.66)MGYMAAK 92.151 0.048172 0.0 18720.0 18265.0 24981.0 18055.0 18370.0 15562.0 14873.0 15882.0 15303.0 17873.0 True False 17679.61734209749 19665.866768768406 23373.74965725628 15595.87785338776 16062.196370116331 17705.524242229218 15564.623970290404 15928.213990593369 18364.027601545316 17356.960050369078 1.018589504774573 1.1330248333636184 1.3466499657443909 0.8985374056360825 0.9254037759783162 1.0200820991031045 0.8967367514312761 0.917684545241243 1.0580209638239517 1.0 14.083226671554266 -5.786291142698001 24.999997553559318 0.9545542924406967 1.1627819392869223 0.5239846360434091 0.09013266274341072 168.83958980159474 169846.03026130213 0.025511222755308732 0.037857192075270225 1.6357195987182818e-06 5.786291142698001 0.20822764684622563 DNSTMGYMAAK ddPTM_A459_Selumetinib_30min_R1 1 DNSTMGYMAAK 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 158.41 0.0079344 10048000.0 910.24 923.44 1166.0 1354.6 849.61 1015.8 977.25 956.61 600.51 914.57 False True 931.4468209812791 815.3232155043908 1007.6636043795403 1118.0445389912422 772.7629255108285 1005.581974272606 903.535245711511 931.2375952927971 1019.0216104849168 1031.9639681661977 0.9025962627711336 0.7900694604223653 0.9764523137083563 1.0834143182130767 0.7488274293956503 0.9744351598433494 0.8755492183676676 0.9023935176221399 0.9874585178547662 1.0 10.011176883470306 -14.522878658911349 0.12390780335098817 1.2959696274341659 0.8732094030785539 0.09234656033148647 0.09158198472016149 415.1298641596508 3.2879307698698685 30.34093263506677 0.8133965262194298 3.000000596615896e-15 14.522878658911349 -0.422760224355612 DNTFFRES(ph)PVGR ddPTM_A459_Selumetinib_30min_R1 4 DNTFFRESPVGR 12 1 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;F8VWU8;F8VPY7 F8WF16 PPHLN1 Periphilin-1 1 DNTFFRES(1)PVGR;DNTFFRES(1)PVGR;DNTFFRES(1)PVGR;DNTFFRES(1)PVGR 120.29 0.016182 359357000.0 13529.5 16035.5 16453.399999999998 18267.2 16315.300000000001 14819.2 15658.099999999999 14269.9 8523.7 12191.2 True False 13844.711026175739 14158.056205298299 14219.118652056877 15077.176437812495 14839.583995700175 14670.132302757042 14476.996910591366 13891.415896832226 14464.096353583273 13756.05927234411 1.0064445603262164 1.0292232626361522 1.0336622117239438 1.0960389265059673 1.078767087427025 1.0664487563128366 1.0524087330516718 1.0098397820050284 1.0514709239922102 1.0 13.747779616849318 -10.491020566540309 13.679355241511937 1.0000025207532852 1.0482147497531111 0.21258821770375602 0.02714978491262244 0.0 0.0 0.028919928625915702 0.007014112965292605 3.228341236089905e-11 10.491020566540309 0.04821222899982591 DNTFFRES(ph)PVGR ddPTM_A459_Selumetinib_30min_R2 2 DNTFFRESPVGR 12 1 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;F8VWU8;F8VPY7 F8WF16 PPHLN1 Periphilin-1 1 DNTFFRES(1)PVGR;DNTFFRES(1)PVGR 84.62 0.017807 343930000.0 154789.0 145271.0 171317.0 175497.0 155990.0 138612.0 123000.0 130334.0 106862.0 157271.0 True False 146186.4470494619 156412.81858011248 160294.650735846 151594.00585078905 136393.14163170636 157704.5448055439 128719.74371987637 130713.25036204486 128237.38597375232 152730.1775908689 0.9571549601746928 1.0241120716765522 1.049528346423067 0.9925609217641099 0.8930333466715011 1.0325696420520132 0.8427918159349537 0.8558442897394998 0.8396335812381004 1.0 17.220625623403386 -7.264856739868163 24.975456688124584 0.8725544427175341 0.9911869349417818 0.4308389769549352 0.05956987887045683 263.36256904181204 1924746.0202726698 0.024021076084966727 0.016938811813773495 5.434295623023155e-08 7.264856739868163 0.11863249222424765 DNTRPGANS(ph)PEMWSEAIK ddPTM_A459_Selumetinib_30min_R2 2 DNTRPGANSPEMWSEAIK 18 1 F1T0B3;A0A087X2G1;Q92499-3;Q92499-2;Q92499 F1T0B3 DDX1 ATP-dependent RNA helicase DDX1 1 DNTRPGANS(1)PEMWSEAIK;DNT(0.005)RPGANS(0.992)PEMWS(0.003)EAIK 129.2 0.00035298 26686000.0 66860.0 66592.0 73188.0 72123.0 65826.0 51269.0 65564.0 60785.0 46933.0 56959.0 True False 63144.188861786264 71699.39227297164 68479.16376106936 62299.72298088541 57556.34938809345 58330.83937635589 68612.85591260128 60961.87428650151 56320.911417586496 55314.44567274512 1.1415496999710342 1.2962146036347213 1.237997830914011 1.1262830572228282 1.0405301669045375 1.0545317532685143 1.240414779143464 1.1020968129585547 1.0181953508274475 1.0 15.75536867698706 -1.5228787452804633 0.11248008430934316 0.9405393454106847 1.8597932620471216 0.4076656062555306 0.07514494963244006 112.92517139860054 0.8867758411681645 0.700100714667562 16.14017834009945 0.029999999999991315 1.5228787452804633 0.9192539166364369 DPALCQHKPLT(ph)PQGDELSEPR ddPTM_A459_Selumetinib_30min_R2 2 DPALCQHKPLTPQGDELSEPR 21 1 K7EQL6;Q8NFA0 K7EQL6 USP32 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 32 1 DPALCQHKPLT(0.92)PQGDELS(0.08)EPR;DPALCQHKPLT(0.979)PQGDELS(0.021)EPR 71.857 0.002876 14994000.0 63942.0 63405.0 56558.0 73235.0 66660.0 47829.0 58990.0 54406.0 41666.0 67065.0 True False 60388.359620106734 68267.95962079172 52919.11985569438 63260.2666625784 58285.574852038946 54417.010601566726 61733.15188646748 54564.31245260185 50000.36424531057 65128.659194203734 0.9272163801198157 1.048201520888478 0.8125320022004081 0.9713122831831363 0.8949297524802444 0.8355309517320707 0.9478646213549189 0.8377926572985234 0.7677167757471731 1.0 15.991004905720294 -5.35909354715782 0.7841029063182048 0.8729573233184675 0.9970620433872461 0.11853333200558824 0.0802695557116108 2.540654051556871 2.049036559920516 0.03360495873261304 0.2397589336399548 4.374278729186336e-06 5.35909354715782 0.1241047200687786 DPAQPMS(ph)PGEATQSGAR ddPTM_A459_Selumetinib_30min_R1 7 DPAQPMSPGEATQSGAR 17 0 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 DPAQPMS(1)PGEATQSGAR;DPAQPMS(0.968)PGEAT(0.032)QSGAR;DPAQPMS(0.998)PGEAT(0.001)QSGAR;DPAQPMS(0.988)PGEAT(0.012)QSGAR;DPAQPMS(0.997)PGEAT(0.002)QSGAR;DPAQPMS(1)PGEATQSGAR;DPAQPMS(0.998)PGEAT(0.002)QSGAR 219.96 6.612000000000001e-12 180347200.0 12652.04 19961.260000000002 10179.27 11089.89 13117.91 12643.45 15494.869999999999 13987.42 6803.02 13169.220000000001 True False 12946.807915415693 17624.186399461985 8796.981044727714 9153.248894517636 11931.397356655114 12516.268372334098 14326.079480908591 13616.42818405659 11544.228067078153 14859.617666065633 0.8712746321180151 1.1860457513459244 0.5920058807984716 0.6159814539118712 0.8029410732351756 0.842300835297872 0.9640947568674352 0.9163377207982902 0.7768859419203824 1.0 13.859109375751183 -7.049439032882515 6.361315750014454 0.9073336800059107 0.811995665713924 0.07998064387477288 0.1610108898305273 0.7302677221636396 71.39747376285084 0.06656583975011317 0.05219677289584532 8.924028880756149e-08 7.049439032882515 -0.09533801429198674 DPAQPMS(ph)PGEATQSGAR ddPTM_A459_Selumetinib_30min_R2 10 DPAQPMSPGEATQSGAR 17 0 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 DPAQPMS(0.832)PGEAT(0.168)QSGAR;DPAQPMS(0.966)PGEAT(0.034)QSGAR;DPAQPMS(0.5)PGEAT(0.5)QSGAR;DPAQPMS(0.999)PGEAT(0.001)QSGAR;DPAQPMS(1)PGEATQSGAR;DPAQPMS(0.999)PGEAT(0.001)QSGAR;DPAQPMS(0.993)PGEAT(0.006)QS(0.001)GAR;DPAQPMS(0.788)PGEAT(0.196)QS(0.016)GAR;DPAQPMS(1)PGEATQSGAR;DPAQPMS(1)PGEATQSGAR 233.57 9.4038e-17 465878800.0 191317.0 131784.1 178840.0 204852.0 223750.0 198303.0 231482.0 247902.0 202418.0 185339.0 True False 180684.3670426319 141891.51671733093 167333.62910626936 176950.80421058903 195640.52464962043 225617.4382345959 242246.3716728813 248623.3537776149 242907.25603147058 179987.78150144647 1.0038701823833516 0.7883397169167876 0.9296943809762142 0.9831267585748146 1.086965587428212 1.2535153017194265 1.3459045366973117 1.3813346200704009 1.3495763657130162 1.0 17.45753944673853 -6.490971033622052 1.5611682550489252 1.3036657990759404 0.8999115531547449 0.6644243862839921 0.1133962170888012 0.20302284664233414 1.0047360953001359 0.04300979638893669 0.04858058203664314 3.228709461542181e-07 6.490971033622052 -0.40375424592119546 DPAQPMS(ph)PGEATQSGARPADR ddPTM_A459_Selumetinib_30min_R1 2 DPAQPMSPGEATQSGARPADR 21 1 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 DPAQPMS(1)PGEATQSGARPADR;DPAQPMS(0.863)PGEAT(0.104)QS(0.033)GARPADR 111.25 5.6727e-05 196842000.0 4056.9 4267.3 5129.8 5658.2 4856.8 4179.4 4362.700000000001 4208.299999999999 2104.82 3305.8 True False 4151.417876646761 3767.682532186054 4433.201335974409 4670.101587568469 4417.503297537686 4137.35903059158 4033.6180265700805 4096.682213515096 3571.7258100295826 3730.1316312188414 1.1129413884223336 1.0100669104148858 1.188483885895961 1.2519937764347708 1.1842754450180737 1.1091723938009328 1.081360773655077 1.098267465745299 0.9575334500628604 1.0 11.865010826766163 -7.931056508635352 1.3125927236866122 0.9803378459541846 1.1447283476060537 0.47678183593035783 0.06347971099120975 0.44315951889292915 1.3736164474397414 0.06256504789583062 0.02201174492440824 1.1720428541669479e-08 7.931056508635352 0.16439050165186908 DPAQPMSPGEAT(ph)QSGARPADR ddPTM_A459_Selumetinib_30min_R1 2 DPAQPMSPGEATQSGARPADR 21 1 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 DPAQPMS(0.087)PGEAT(0.871)QS(0.042)GARPADR;DPAQPMS(0.015)PGEAT(0.803)QS(0.181)GARPADR 67.64399999999999 0.013103 165706000.0 4858.2 4791.4 5428.700000000001 5977.200000000001 5242.6 4931.4 4506.7 4196.1 2859.3999999999996 3735.6 True False 4971.386607588382 4230.420660538569 4691.512357714586 4933.3942259400965 4768.407755656204 4881.794593352949 4166.755990635016 4084.8057971462836 4852.19295768692 4215.100647825368 1.1794229896154895 1.0036345544254335 1.1130249903131035 1.1704095911648769 1.1312678282347293 1.1581679777614655 0.9885306043130209 0.9690885552765377 1.15114521884317 1.0 12.041351364793842 -7.261434754815834 24.99999999878844 1.0246151396523155 1.1220963987864216 0.3562317807951588 0.06490172641845877 0.49542637169034315 2676292.250915358 0.026094502963650082 0.018885859458401936 5.477283814336454e-08 7.261434754815834 0.0974812591341061 DPAQPMSPGEAT(ph)QSGARPADR ddPTM_A459_Selumetinib_30min_R2 4 DPAQPMSPGEATQSGARPADR 21 1 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 DPAQPMS(0.046)PGEAT(0.804)QS(0.149)GARPADR;DPAQPMS(0.126)PGEAT(0.437)QS(0.437)GARPADR;DPAQPMS(0.11)PGEAT(0.542)QS(0.347)GARPADR;DPAQPMS(0.099)PGEAT(0.535)QS(0.366)GARPADR 85.287 0.0034785 521985000.0 147746.0 124912.0 141329.0 147924.0 166019.0 110119.0 112191.0 112303.0 89982.0 145225.0 True False 139534.86879409925 134492.34874461513 132236.0460073803 127776.49601686698 145162.20899130896 125286.89268924561 117408.10380224907 112629.78313723746 107980.91430714568 141031.97691013518 0.9893846193690535 0.9536301744554919 0.9376316556325407 0.9060108126987787 1.0292857844842205 0.888358054918834 0.832492789043586 0.7986116737837728 0.7656484484788193 1.0 17.10566278386443 -6.988617519470048 5.652241671387698 0.8355639607071851 0.9585933684409768 0.40119952803726167 0.0652191892399933 0.15211755117210854 16.60454976765748 0.023040080013005806 0.01950859062485657 1.0265556095905403e-07 6.988617519470048 0.12302940773379167 DPAQPMSPGEATQS(ph)GARPADR ddPTM_A459_Selumetinib_30min_R1 1 DPAQPMSPGEATQSGARPADR 21 1 Q9BQG0;Q9BQG0-2 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 DPAQPMS(0.008)PGEAT(0.373)QS(0.618)GARPADR 109.37 0.00055641 29410000.0 1660.0 1779.8 2235.7 2241.2 2206.6 1673.5 1786.8 2093.5 1043.6 1680.5 True False 1698.6747702022792 1571.4201885934274 1932.104219821044 1849.816492534454 2007.0134196068725 1656.6661094164267 1652.020237439066 2037.9735793536245 1770.912978471732 1896.2085444561874 0.8958269780866541 0.8287169642746727 1.018930236059637 0.9755343092101517 1.058434962480597 0.8736729481891145 0.8712228632599311 1.0747623647788667 0.9339231086418351 1.0 10.888901924798871 -5.257885061772071 24.873061025967456 0.9740382084186001 0.8622719667339508 0.31660992050205006 0.06668208094015604 343.9471868735226 2406908.334679056 0.017474895132972724 0.042584768108249835 5.522235686992805e-06 5.257885061772071 -0.11176624168464933 DPDANWDSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 DPDANWDSPSR 11 0 Q9UHB7;Q9UHB7-2;Q9UHB7-3 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 DPDANWDS(0.203)PS(0.797)R 94.023 0.023409 0.0 14088.0 9700.2 13085.0 20345.0 15080.0 14997.0 12181.0 20369.0 19279.0 13207.0 True False 13305.04535873234 10444.174148940996 12243.1253458708 17573.975902917417 13185.515583089515 17062.700620788557 12747.440636193596 20428.270417730517 23135.338700267424 12825.679594093028 1.037375467016975 0.8143174069116108 0.9545790736507617 1.3702179111827537 1.0280559003799075 1.3303545044620422 0.9938998197073732 1.5927631957326398 1.8038294603057599 1.0 13.646747651467697 -6.408750288066234 0.6319528897704734 1.429382717713998 0.9003010803177369 0.284794897757497 0.25536075362770927 1.0721988358218464 0.9321399449343338 0.18521405327685178 0.29777036227704085 3.9016626115142397e-07 6.408750288066234 -0.529081637396261 DPEDRIPS(ph)PLGYAAIPIK ddPTM_A459_Selumetinib_30min_R1 2 DPEDRIPSPLGYAAIPIK 18 1 Q9Y3A4 Q9Y3A4 RRP7A Ribosomal RNA-processing protein 7 homolog A 1 DPEDRIPS(1)PLGYAAIPIK;DPEDRIPS(1)PLGYAAIPIK 96.016 0.0021231 26635000.0 5605.9 7104.3 6447.0 7132.8 6665.9 5887.2 6177.5 5829.200000000001 3348.33 5341.700000000001 True False 5736.506562817443 6272.525253300536 5571.532810836103 5887.190379238689 6062.970521960233 5827.980113149913 5711.526201466215 5674.590680089871 5681.871457652597 6027.359227564189 0.9517445943131074 1.0406755291131744 0.9243737763889184 0.9767445670594044 1.0059082747603938 0.9669209836535909 0.9476000991190946 0.9414721216779243 0.9426800764866288 1.0 12.557310335912256 -6.999398883896208 24.998847811841475 0.9536607186339391 0.9806481687340913 0.08569630467204103 0.032729215402841016 43.352397257272344 1802808.0187239656 0.011234994874623486 0.009825127493193376 1.001385079317294e-07 6.999398883896208 0.026987450100152244 DPEDRIPS(ph)PLGYAAIPIK ddPTM_A459_Selumetinib_30min_R2 1 DPEDRIPSPLGYAAIPIK 18 1 Q9Y3A4 Q9Y3A4 RRP7A Ribosomal RNA-processing protein 7 homolog A 1 DPEDRIPS(0.948)PLGY(0.052)AAIPIK 57.188 0.033622000000000006 2958900.0 18293.0 16508.0 21284.0 20686.0 20640.0 16139.0 15562.0 15476.0 16543.0 20931.0 True False 17276.34829268107 17774.110518413836 19914.610612267024 17868.531114659607 18047.01867605884 18362.00075474474 16285.663835517993 15521.03259781028 19852.062250040148 20326.667644730893 0.849935099773202 0.8744232369549894 0.9797282545439423 0.8790683956153291 0.8878493509848385 0.9033453527983748 0.8011969359738897 0.7635797893233948 0.9766510968258109 1.0 14.311086098594537 DPEEIEKEEQAAAEK ddPTM_A459_Selumetinib_30min_R2 1 DPEEIEKEEQAAAEK 15 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 121.42 0.0023522 0.0 12849.0 9382.0 11018.0 14039.0 13698.0 14273.0 16899.0 15385.0 13844.0 12373.0 False True 12134.904018622363 10101.569232115256 10309.113875491363 12126.863981374181 11977.134778326266 16238.976192606193 17684.836984733232 15429.767802876133 16613.18683367924 12015.759341085259 1.009915701051844 0.8406933715437486 0.8579660746234825 1.0092465766944103 0.9967855079597904 1.3514731555150716 1.4718035275776375 1.2841275665464953 1.3826164757539778 1.0 13.552640202632467 -6.6911856850704226 4.14387463116199 1.3277389492842218 0.9274037746174102 0.6606864075358592 0.12680579266257103 0.12083012873956052 4.045588051712422 0.042264253880352765 0.041325320225089585 2.036171314967923e-07 6.6911856850704226 -0.40033517466681157 DPES(ph)PCVENLTSIGLNR ddPTM_A459_Selumetinib_30min_R1 1 DPESPCVENLTSIGLNR 17 0 A0A494C151 A0A494C151 1 DPES(0.998)PCVENLTS(0.002)IGLNR 79.23 0.017915 2391800.0 164.12 261.43 348.84 396.83 289.73 216.97 398.34 276.23 220.01 241.78 True False 167.94367667807109 230.82165406449028 301.4694440409595 327.53108992167034 263.52397265598603 214.78747879299783 368.2928930946262 268.9034830785055 373.3409011053715 272.81481813663623 0.615595874979043 0.8460744751367788 1.1050332459946215 1.200561949525887 0.965944498381327 0.7873013652998274 1.3499739332713623 0.9856630402818816 1.3684773563816752 1.0 8.091778197302673 -4.988627368591246 2.461094960891325 1.0923991009209193 0.5980267451667916 0.4543169820842986 0.1688603340237579 0.32596122522254145 3.3481086241914624 0.04445756254921901 0.28356433721946667 1.0265323291750845e-05 4.988627368591246 -0.49437235575412775 DPFS(ph)PDK ddPTM_A459_Selumetinib_30min_R2 1 DPFSPDK 7 0 H0YHD0;Q5PSV4-2;Q5PSV4 H0YHD0 BRMS1L Breast cancer metastasis-suppressor 1-like protein 1 DPFS(1)PDK 96.665 0.022999 3012300.0 33264.0 27400.0 26515.0 27121.0 29056.0 23235.0 25156.0 26424.0 19375.0 26404.0 True False 31415.320046342473 29501.49189511382 24809.05376734921 23427.073013665446 25405.725516064227 26435.410343670213 26325.80384566833 26500.889465271317 23250.541382731542 25641.647914169174 1.2251677486368908 1.1505302620902051 0.9675296162864835 0.9136336748746952 0.9907992497637181 1.0309559834905313 1.0266814338060193 1.0335096072599663 0.9067491083474263 1.0 14.646201362301834 -5.133172651431026 3.545410316630262 0.9858835316342325 1.2121762911298697 0.7863196165776297 0.04321954910157524 0.11090422607466857 2.4714048872385415 0.012097483713264441 0.03995748845198175 7.3591448049828825e-06 5.133172651431026 0.2262927594956372 DPHLACVAYER ddPTM_A459_Selumetinib_30min_R1 1 DPHLACVAYER 11 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 102.05 0.02061 7837700.0 1275.9 1758.2 1822.2 2114.2 1776.4 1728.4 1670.9 1972.9 1141.5 1387.3 False True 1305.6259875307753 1552.3491266349959 1574.7552486281284 1744.994658449197 1615.7249336488937 1711.0138652616374 1544.862667750693 1920.5722831176322 1937.0421281386375 1565.3734684463366 0.8340667667164656 0.9916797223960442 1.005993317486787 1.1147465404413286 1.0321657842154 1.0930387538507675 0.9868971838931185 1.2269099494984013 1.2374313013374305 1.0 10.612291182584507 -3.5269566569100523 0.5180551464599605 1.1193578827125823 7.467100182273882e-15 0.5051320121721139 0.08057234138583916 12.39488897818506 0.9304210986436643 0.045692807286974974 11.183178037467213 0.00029719626222335144 3.5269566569100523 -1.1193578827125747 DPHLACVAYER ddPTM_A459_Selumetinib_30min_R2 2 DPHLACVAYER 11 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 ; 98.156 0.026031 7845800.0 16334.6 15671.0 15700.2 21030.0 17339.0 17216.0 14562.3 14886.6 14720.4 18738.3 False True 15426.788324584715 16872.91530979302 14690.06622508527 18165.677721226504 15160.719807373278 19587.347728712128 15239.475804650036 14929.917541390703 17664.891322341216 18197.27659104969 0.8477525879983802 0.927222006291422 0.8072672936295623 0.9982635385209935 0.8331312507955208 1.0763889657173284 0.8374591510108471 0.820447909701717 0.9707436843065668 1.0 14.151434932029275 -5.75260063429119 24.999959471889422 0.9240304523706545 0.8673947973714999 0.12819210059599428 0.08410957728290051 506.42380530608705 1432380.1436251318 0.02237248188188518 0.0380081871705421 1.7676625692384731e-06 5.75260063429119 -0.05663565499915457 DPHLLDPTVEY(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 DPHLLDPTVEYVK 13 0 O75815 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 DPHLLDPT(0.008)VEY(0.992)VK 138.02 0.006593099999999999 5773300.0 3399.2 4709.4 2670.9 3036.6 3499.0 3260.1 3795.1 3718.9 2609.1 3941.3 True False 3478.394746308184 4158.021258659339 2308.206450203528 2506.314814041639 3182.516067798625 3227.3063539339646 3508.83255154746 3620.262691310335 4427.452138875621 4447.204246513042 0.7821531356549498 0.9349742058551853 0.5190241604066969 0.5635708807408131 0.7156217460203156 0.7256933064102974 0.7889973918554923 0.8140536145037427 0.9955585337343326 1.0 12.11868294945154 -8.015908113331067 1.2872378414961771 1.0137985317593252 0.7025330396910209 0.5129867371442273 0.10856525988705833 0.40062274909456036 1.1986359983778379 0.10749074422432786 0.036577384728601434 9.640329691303006e-09 8.015908113331067 -0.31126549206830434 DPHLLDPTVEY(ph)VK ddPTM_A459_Selumetinib_30min_R2 3 DPHLLDPTVEYVK 13 0 O75815 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 DPHLLDPTVEY(1)VK;DPHLLDPTVEY(1)VK;DPHLLDPTVEY(1)VK 166.45 0.0021662 10969600.0 77473.0 58515.0 72845.0 67936.0 70059.0 55356.0 87186.0 82874.0 58824.0 66922.0 True False 73167.36080899136 63002.91234461994 68158.23200763913 58682.999603863194 61257.56208459334 62980.78652826381 91240.32175578151 83115.14961947076 70590.4436798864 64989.78797576227 1.1258285815038955 0.969427879471105 1.048752952280111 0.9029572403859638 0.9425721177523944 0.9690874288088505 1.40391782459437 1.278895534333306 1.086177473085662 1.0 15.987925420857154 -7.227645420809251 24.71461358234179 1.2154890433121688 0.9881630871312542 0.40692123241395806 0.1163439750029024 476.0979616413488 348186.23687186895 0.043883225546471887 0.03398971099067231 5.9204481115529434e-08 7.227645420809251 -0.22732595618091456 DPLEGRVGRASDYGMK ddPTM_A459_Selumetinib_30min_R1 1 DPLEGRVGRASDYGMK 16 2 F5GX14;Q14165 F5GX14 MLEC Malectin 0 83.729 0.027892 15514000.0 5068.9 6791.5 4548.9 4735.5 4077.0 4432.5 5082.9 5498.1 3535.0 5622.4 False True 5186.995507637551 5996.348022717307 3931.1843653191177 3908.533821344329 3708.2360698528105 4387.913074387994 4699.4927607337295 5352.272527654241 5998.6368138152275 6344.089806813727 0.817610668447123 0.9451864972461557 0.6196608946325 0.616090556780337 0.5845182181800237 0.6916536820893132 0.7407670609716693 0.843662793345982 0.9455472725768362 1.0 12.631197478611883 -8.05020307402919 1.7069460967152508 0.9913570344331223 0.7086924115079936 0.5181424228949507 0.10027907363081619 0.3448395215206564 1.7954896899625241 0.10124122839704448 0.032729651209225184 8.908342908629445e-09 8.05020307402919 -0.28266462292512873 DPLPDAGAS(ph)PAPSR ddPTM_A459_Selumetinib_30min_R2 2 DPLPDAGASPAPSR 14 0 O15297-2;O15297 O15297-2 PPM1D Protein phosphatase 1D 1 DPLPDAGAS(1)PAPSR;DPLPDAGAS(0.994)PAPS(0.006)R 111.81 0.0038139 6137400.0 27198.0 23611.0 27307.0 28263.0 28161.0 23918.0 26031.0 25301.0 21359.3 22774.0 True False 25686.444042220504 25421.887778669094 25550.097349613607 24413.53064360557 24623.163417465756 27212.48739401353 27241.493079447962 25374.621721193966 25631.756828705948 22116.455446041837 1.1614177554304972 1.1494557905398366 1.1552528121854302 1.1038627190133596 1.11334130722437 1.2304181138069177 1.2317296117323062 1.1473186462044596 1.1589450620258972 1.0 14.432832566199055 -9.204806544017233 2.240709441393351 1.0000000316277178 1.16174397009592 0.5986171175315158 0.039631891033598245 17.16329966594502 55.09026666313889 0.042627566425598146 0.011600887748319622 6.240127393465034e-10 9.204806544017233 0.16174393846820223 DPLQNS(ph)PGSEGK ddPTM_A459_Selumetinib_30min_R2 2 DPLQNSPGSEGK 12 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 DPLQNS(0.757)PGS(0.243)EGK;DPLQNS(0.758)PGS(0.242)EGK 95.195 0.01826 65298000.0 153558.0 156327.0 151614.0 159022.0 189535.0 134760.0 150854.0 152936.0 136368.0 162858.0 True False 145023.86110137863 168316.77822946923 141859.32030484162 137362.9292717487 165723.9188356014 153321.9667705185 157869.00991153024 153381.01844008215 163645.4104402752 158155.86638409915 0.9169679533048241 1.064246190025561 0.8969589528871502 0.8685288279990039 1.0478518604749214 0.9694358500629944 0.998186241970486 0.9698092264726953 1.034709708730273 1.0 17.27098754433753 -6.278919389574247 24.997135104675966 0.999870494801514 0.9429507691783167 0.2687497623622742 0.05328259265952537 1355.538895735166 1938472.2924850162 0.0169586525316184 0.019271319056684656 5.26114910761104e-07 6.278919389574247 -0.05691972562319736 DPLQNSPGS(ph)EGK ddPTM_A459_Selumetinib_30min_R1 1 DPLQNSPGSEGK 12 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 DPLQNS(0.329)PGS(0.671)EGK 115.12 0.0053354 10769000.0 2526.1 2662.8 2804.6 3473.5 2401.8 2313.3 2710.3 2747.6 1599.2 2489.9 True False 2584.9532150650475 2351.038138097865 2423.750724565059 2866.9184306703673 2184.5576140722296 2290.030302308346 2505.859888924953 2674.7247225373844 2713.725599053272 2809.5029186798324 0.9200749349211215 0.8368164070826462 0.8626973506416445 1.0204361816493552 0.7775601867318007 0.8151015922006647 0.8919228637436122 0.9520277429696427 0.9659095141030979 1.0 11.45609918372296 -7.808279709437678 2.795335819101288 0.9776720473208893 0.8713052525128775 0.35126742771252395 0.06208989183969744 0.32807137496969113 5.11894415542025 0.04130718517665418 0.017919856706138312 1.554963827143191e-08 7.808279709437678 -0.10636679480801181 DPPSITPAVKS(ph)PLPGPSEEK ddPTM_A459_Selumetinib_30min_R2 1 DPPSITPAVKSPLPGPSEEK 20 1 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 DPPSIT(0.001)PAVKS(0.842)PLPGPS(0.157)EEK 61.801 0.013880000000000002 2544900.0 15076.0 11757.0 10412.0 15094.0 14095.0 11542.0 14380.0 12010.0 11077.0 10828.0 True False 14238.136274009708 12658.724095286614 9742.10325572845 13038.171161397675 12324.26008910124 13131.80573215587 15048.698493429436 12044.947111637468 13292.709517239597 10515.36750547734 1.3540312563106538 1.203830877874009 0.9264634118259677 1.2399158806961559 1.172023715070507 1.2488204264202518 1.431114840788088 1.1454613550466388 1.264122201179899 1.0 13.360211651784097 DPQT(ph)PVLQTK ddPTM_A459_Selumetinib_30min_R1 1 DPQTPVLQTK 10 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 DPQT(0.998)PVLQT(0.002)K 107.97 0.025649 4175800.0 2849.3 3689.4 3044.7 3269.0 2771.8 2861.6 3112.6 2899.7 1806.1 3090.5 True False 2915.6831462273203 3257.443332844473 2631.2464633399513 2698.1305167299365 2521.091179401037 2832.8149021249146 2877.8140760313618 2822.790536446955 3064.8197876751583 3487.195779019246 0.8361111136259002 0.9341154151547552 0.754545092985853 0.7737249892774217 0.7229565929648147 0.8123475370005259 0.8252516515837063 0.8094729161552405 0.8788780389431193 1.0 11.767851647196938 -8.656382334491006 1.6570263748088994 1.0000352826942525 0.8061445433806462 0.5500270398286976 0.05324981490118372 0.4646083526022511 2.6252444082811803 0.055303569429283606 0.015851839263199545 2.2060617544351583e-09 8.656382334491006 -0.19389073931360623 DPQT(ph)PVLQTK ddPTM_A459_Selumetinib_30min_R2 2 DPQTPVLQTK 10 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 DPQT(0.987)PVLQT(0.013)K;DPQT(1)PVLQTK 141.34 0.003085 39504000.0 325960.0 256170.0 280190.0 311100.0 313190.0 333050.0 360800.0 330780.0 320880.0 318880.0 True False 307844.4481212657 275817.4152836246 262162.8804478054 268727.64332256635 273844.2722458759 378924.61437311664 377577.91491163685 331742.51503642334 385064.9661363046 309673.10585025966 0.9940948771641854 0.8906728097240523 0.8465794268055441 0.8677784355368199 0.8843011132464679 1.2236277778553462 1.219279000270085 1.0712667931739452 1.2434562732822532 1.0 18.240386569295552 -6.754111622081798 24.999947424685978 1.1602147142777715 0.8919616543926223 0.7257921576589412 0.07820191615743118 82.6063035772201 281825.8412254304 0.02521819220383062 0.024728810205599885 1.7615232426804234e-07 6.754111622081798 -0.26825305988514914 DPS(ph)ASPGDAGEQAIR ddPTM_A459_Selumetinib_30min_R1 1 DPSASPGDAGEQAIR 15 0 P18206;P18206-2 P18206 VCL Vinculin 1 DPS(0.5)AS(0.5)PGDAGEQAIR 210.02 1.2741e-06 37114000.0 824.51 728.32 623.35 551.59 503.09 559.88 773.94 956.08 460.32 500.19 True False 843.7194787828197 643.0479558132184 538.7024938164545 455.2651611266638 457.5855983277538 554.2481155303662 715.5610826973317 930.7216526144794 781.1294195574045 564.3942587631899 1.4949115191776425 1.1393594917538492 0.9544790462556509 0.8066438558824626 0.8107552322210082 0.9820229510217594 1.2678390532628874 1.6490629345770758 1.3840137588733923 1.0 9.140559502132293 -7.402754329691054 4.254488088773382 1.3985605976949795 1.0137644110917128 0.2613343661243247 0.23673353114608164 0.2760591180387549 8.259709694868201 0.1095386281247615 0.07106717624390516 3.955903330577616e-08 7.402754329691054 -0.38479618660326675 DPS(ph)ASPGDAGEQAIR ddPTM_A459_Selumetinib_30min_R2 2 DPSASPGDAGEQAIR 15 0 P18206;P18206-2 P18206 VCL Vinculin 1 DPS(0.5)AS(0.5)PGDAGEQAIR;DPS(0.846)AS(0.154)PGDAGEQAIR 203.2 1.0282e-05 219204000.0 27204.0 18043.2 31048.0 35254.0 45746.0 31181.0 35159.0 34681.0 39959.0 25839.0 True False 25692.110586240397 19427.05542196781 29050.40548250644 30452.344383457905 39998.978505571125 35475.89971706397 36793.96316623681 34781.91596825136 47951.91654774552 25092.960932215447 1.0238772002890952 0.7742033901239013 1.157711342275684 1.2135811499376243 1.5940318328164564 1.413778940352888 1.4663061591507562 1.3861224294019763 1.9109708366931994 1.0 14.614995096218626 -5.774239548738003 1.7240822121950456 1.477858953074736 0.9040449616406212 0.48279758763524283 0.22488548757990084 0.2811537108262711 1.701597245779243 0.06711758504100142 0.13993238255763904 1.6817461853579109e-06 5.774239548738003 -0.5738139914341147 DPS(ph)PEADAPVLGSPEK ddPTM_A459_Selumetinib_30min_R2 1 DPSPEADAPVLGSPEK 16 0 O15234 O15234 CASC3 Protein CASC3 1 DPS(1)PEADAPVLGSPEK 117.13 0.0019425 0.0 5516.5 3240.8 4709.9 5846.6 5112.4 3490.7 8449.5 7347.8 6815.2 3258.2 True False 5209.915014299188 3489.3589391855808 4406.870161751385 5050.282994052444 4470.134606564112 3971.512239580358 8842.418492366616 7369.180881506231 8178.430432598288 3164.1273001797426 1.646556702697528 1.102787153660778 1.3927600705259384 1.596106134467332 1.4127543497728994 1.2551682858508098 2.7945836729970726 2.328977371134093 2.584734954290145 1.0 11.627591928607915 -7.246290750428009 24.976305446928535 2.287822125694637 1.396491135720497 0.38673910071668616 0.4705354280084523 680.8609430904354 1122571.0438833318 0.1682697230565342 0.12982095108127795 5.671647741659205e-08 7.246290750428009 -0.8913309899741402 DPS(ph)PESNKKGESPSLESR ddPTM_A459_Selumetinib_30min_R1 1 DPSPESNKKGESPSLESR 18 2 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;Q8NDX5-3 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 DPS(0.978)PES(0.022)NKKGESPSLESR 78.67399999999998 0.014396 12423000.0 1378.1 1080.8 2114.5 2411.9 1725.7 1554.8 1361.2 1350.1 703.81 1049.2 True False 1410.2070486841933 954.2594335497114 1827.3625141170985 1990.7069419703068 1569.6107396970817 1539.1601236454499 1258.5235880915925 1314.290962257142 1194.3141657514268 1183.8750400734486 1.1911789681761538 0.806047430048452 1.5435434080979757 1.6815177908023144 1.3258246745363444 1.3001035341956015 1.0630544149435843 1.1101602092866172 1.0088177597504975 1.0 10.20930109486849 -7.258808926561069 4.471092653016937 1.0517190623590802 1.31539547037295 0.26056718611570295 0.21656834007911638 0.3375856808057106 18.043553880447835 0.10065150357408938 0.07151264452669472 5.510500846475013e-08 7.258808926561069 0.2636764080138698 DPSASNGGGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 DPSASNGGGSPAR 13 0 O60504-2;O60504;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 DPSASNGGGS(1)PAR;DPSASNGGGS(1)PAR 173.19 0.00015596 8113500.0 886.45 1344.38 760.37 1184.77 1190.792 963.907 970.64 919.76 606.58 887.863 True False 907.1025602685605 1186.9793646146936 657.11593041344 977.8721603873132 1083.0850738514032 954.2109707375316 897.4238433332529 895.3649769984661 1029.3219571496588 1001.8288645679878 0.9054466210251633 1.1848125030082328 0.6559163482445716 0.9760870294039639 1.0811078739665332 0.9524690338693823 0.8957855728385737 0.8937304650176641 1.027442903228314 1.0 9.968420368718498 DPSASNGGGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 DPSASNGGGSPAR 13 0 O60504-2;O60504;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 DPSASNGGGS(1)PAR 110.6 0.005538800000000001 4664500.0 7182.2 6822.1 6760.6 6663.6 7613.1 6117.9 6155.5 7438.3 6444.7 8497.0 True False 6783.042076624608 7345.333133491096 6325.630356384722 5756.006184648834 6656.674316022462 6960.585192233272 6441.742946891855 7459.94422152315 7733.820079963349 8251.669532142678 0.8220205681047533 0.890163269975714 0.7665879409911573 0.697556556552283 0.8067063628872629 0.8435365916097036 0.7806593467902918 0.9040527122983385 0.9372430693979984 1.0 13.010470329118952 -8.11549054143117 1.4293181722121626 0.9938820989003968 0.7987289756538024 0.6583281850025033 0.04962797699826739 0.2695173139479056 0.9996658583340541 0.049456032135161906 0.015899617294961157 7.664952336028235e-09 8.11549054143117 -0.1951531232465944 DPSASNGGGS(ph)PARR ddPTM_A459_Selumetinib_30min_R1 1 DPSASNGGGSPARR 14 1 O60504-2;O60504;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 DPSASNGGGS(1)PARR 132.25 0.0004225 3389000.0 142.11 436.63 290.16 384.84 393.58 184.84 374.54 340.17 247.67 258.18 True False 145.4208865020759 385.50915661622 250.75786573479175 317.63491834149534 357.9807584921928 182.98067742129197 346.28814625611625 331.14758657211485 420.2779008989016 291.31991788616375 0.4991793474241627 1.3233189114342043 0.8607645764639339 1.0903302480869654 1.2288234909913625 0.6281090518939166 1.1886868181510057 1.1367145404095376 1.4426679231151283 1.0 8.18646053338561 -7.478947566387221 24.99718188470078 1.206355436449485 0.9671503805958522 0.184279529532565 0.25671812957284207 795.0812788386795 452408.3899865647 0.10203221869911046 0.06878521549229571 3.319345305370954e-08 7.478947566387221 -0.23920505585363283 DPSSNDINGGMEPTPSTVSTPS(ph)PSADLLGLR ddPTM_A459_Selumetinib_30min_R1 1 DPSSNDINGGMEPTPSTVSTPSPSADLLGLR 31 0 O95782-2;O95782 O95782-2 AP2A1 AP-2 complex subunit alpha-1 1 DPSSNDINGGMEPTPSTVST(0.003)PS(0.918)PS(0.079)ADLLGLR 131.5 2.716e-18 4556800.0 174.02 306.1 193.12 220.95 228.47 183.28 203.01 151.11 0.0 156.19 True False 178.0743274160245 270.26166969797055 166.89536473222708 182.36523024517558 207.80492883965462 181.43636960492535 187.6967922557113 147.10207192554384 0.0 176.23850791943576 1.010416676345376 1.5334995336065587 0.9469858018119415 1.0347638118256228 1.179111939228678 1.0294933368810957 1.0650157815765977 0.8346761083156065 0.0 1.0 7.461385375750359 -7.985694312605652 4.392188871264689 0.4697575703431558 1.1150754454222034 0.4455563800735597 0.2725577667824 0.1560357610966634 7.309934680751535 0.16354724207609098 0.0678364270178893 1.0334885927029129e-08 7.985694312605652 0.6453178750790476 DPTVHDDVLELEMDELNR ddPTM_A459_Selumetinib_30min_R1 4 DPTVHDDVLELEMDELNR 18 0 P78527-2;P78527 P78527-2 PRKDC DNA-dependent protein kinase catalytic subunit 0 ;;; 240.2 9.961e-24 6119200.0 4405.53 8036.499999999999 4342.49 4470.4400000000005 5159.209999999999 5275.6 5601.44 5752.0599999999995 2881.8999999999996 5355.13 False True 4508.170277330872 7095.58284393251 3752.803709590146 3689.7615745519015 4692.560366432505 5222.532253861544 5178.918871054786 5599.496683475906 4890.373814351938 6042.513098883464 0.746075383463197 1.1742767831556098 0.6210667065469149 0.6106336079327153 0.7765908471592055 0.8642980442734272 0.8570802886652817 0.9266834166252087 0.8093277969485214 1.0 12.560932980112396 -6.889426830290066 3.871596096098064 0.8887627151295098 0.7887046386194332 0.10911153997020828 0.15220647993509098 0.6656354453101215 18.70439643956715 0.05918331168322938 0.05181134090407331 1.2899508698480354e-07 6.889426830290066 -0.10005807651007659 DPVQEAWAEDVDLR ddPTM_A459_Selumetinib_30min_R1 2 DPVQEAWAEDVDLR 14 0 P14618;P14618-3;B4DNK4;P14618-2;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 243.3 1.0648999999999998e-18 18057900.0 1602.29 1890.37 1341.6399999999999 1176.3899999999999 1643.65 1320.44 1689.52 1659.0 854.85 1465.78 False True 1639.6202394863924 1669.044601590829 1159.4526571009992 970.9555700752297 1494.9821477099758 1307.157572463595 1562.0781461596437 1614.9979308085326 1450.6180142262936 1653.9271409062715 0.991349739014477 1.0091403425886547 0.701030068631485 0.587060666737226 0.9038984310341497 0.7903356442577854 0.9444661179595257 0.9764625604508748 0.8770749196554243 1.0 10.691679966711535 -7.27402917677497 21.941811793426716 0.9475395248500688 0.8249806498030362 0.18437945222479613 0.12229259147783562 296.56661356416123 516856.1434021305 0.055859620404926535 0.03805908127257182 5.320725123667255e-08 7.27402917677497 -0.12255887504703256 DPVQEAWAEDVDLR ddPTM_A459_Selumetinib_30min_R2 2 DPVQEAWAEDVDLR 14 0 P14618;P14618-3;B4DNK4;P14618-2;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 187.63 0.0012333 37290000.0 11322.900000000001 10027.4 10200.7 11080.400000000001 8663.6 9262.3 11900.7 12101.099999999999 10284.099999999999 8846.2 False True 10693.61854716003 10796.469336827167 9544.398067682403 9571.23040524386 7575.201114433311 10538.097750212031 12454.106130789676 12136.312197555055 12341.207361762548 8590.787220812119 1.2447774892216596 1.2567497086496966 1.1110038954940076 1.1141272806823233 0.8817819507950982 1.226674282501415 1.449704876942854 1.412712465762569 1.436563034859556 1.0 13.068574624119428 -7.003498306581563 24.95814717038782 1.3561452197017918 1.120782905160283 0.27100256872053485 0.15374742807073877 165.47968940012092 1180597.8490716058 0.05485297108163578 0.04739773535770042 9.91977207188794e-08 7.003498306581563 -0.2353623145415089 DQALTEEHAR ddPTM_A459_Selumetinib_30min_R2 2 DQALTEEHAR 10 0 P12814-4;P12814-3;P12814;P12814-2;H9KV75;H0YJ11 P12814-4 ACTN1 Alpha-actinin-1 0 ; 123.67 0.0057333 3982800.0 40495.0 36289.0 38733.0 42864.0 48414.0 35947.0 40466.0 40534.0 35602.0 37741.0 False True 38244.450014328955 39072.249612473934 36240.96094930178 37025.84925547566 42331.80049334853 40898.372955623585 42347.74918185783 40651.94722923504 42723.394802993964 36651.319267105675 1.0434672142525878 1.066053020567285 0.9888037231398601 1.0102187314361184 1.1549870875000412 1.1158772391674756 1.1554222338693456 1.1091537233073054 1.1656714043943825 1.0 15.161577508764084 -6.256448344560935 24.996153476491873 1.1241894137725859 1.0271774830437919 0.45339293279398063 0.047853658256377 349.0272009800968 1747997.7458956263 0.013531142844617134 0.01690768139807841 5.540534397141911e-07 6.256448344560935 -0.097011930728794 DQDLAS(ph)CDRDR ddPTM_A459_Selumetinib_30min_R2 1 DQDLASCDRDR 11 1 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 1 DQDLAS(1)CDRDR 128.35 0.013255 3084900.0 27168.0 20169.0 28989.0 30888.0 33849.0 27210.0 32478.0 31204.0 23003.0 27350.0 True False 25658.111322120974 21715.89744644347 27123.879300836717 26681.00111522797 29596.5860061006 30957.930512212886 33988.29135393608 31294.798473899707 27604.242757521213 26560.334436165973 0.9660311839742318 0.8176063256520573 1.0212175364743672 1.0045431159517966 1.1143152612491318 1.16557005660512 1.2796635311811362 1.1782531785927755 1.0393032822634116 1.0 14.696985692136414 -5.9259498698954935 1.3744583222287925 1.151641262717288 0.8988560725952376 0.5254127886828992 0.08507478974955406 0.3095141951941942 1.1867931571344572 0.030030042129685318 0.059144714466693935 1.1859056279677944e-06 5.9259498698954935 -0.2527851901220505 DQDMDEDYNR ddPTM_A459_Selumetinib_30min_R2 1 DQDMDEDYNR 10 0 H0YIQ2;P49750-3;P49750-1;P49750 H0YIQ2 YLPM1 YLP motif-containing protein 1 0 150.04 0.010045 2876500.0 28903.0 19277.0 29320.0 27785.0 34310.0 27238.0 31141.0 31600.0 23699.0 26066.0 False True 27296.686967876256 20755.483914675533 27433.583121202286 24000.635068201558 29999.671064708295 30989.787258054195 32589.11820472084 31691.95076833838 28439.462205386044 25313.40685239863 1.0783490000789717 0.8199403594980261 1.0837570494231104 0.9481392689711113 1.1851297314357987 1.2242440315819316 1.287425212842608 1.2519828308031693 1.1234940587497884 1.0 14.627614067886832 -6.278684791705054 10.32313334832488 1.199104168258358 0.9781482874626733 0.4635406153703442 0.10193461225641681 0.3751610602676791 220.4205158191488 0.03002661650079927 0.03476963451547362 5.263991851054381e-07 6.278684791705054 -0.22095588079568473 DQDMS(ph)SPTTMK ddPTM_A459_Selumetinib_30min_R1 3 DQDMSSPTTMK 11 0 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 DQDMS(0.902)S(0.09)PT(0.008)T(0.001)MK;DQDMS(0.471)S(0.471)PT(0.054)T(0.004)MK;DQDMS(0.695)S(0.223)PT(0.079)T(0.003)MK 184.96 2.2195e-05 37864100.0 14644.5 16968.5 14275.1 15902.9 15073.0 13547.2 15150.5 14155.800000000001 7691.0 12561.0 True False 14985.688356763427 14981.820131558361 12336.619827511466 13125.757049404852 13709.649811354282 13410.927467873445 14007.685587262475 13780.342199481267 13051.065271584983 14173.326704501145 1.0573162299295826 1.0570433070452299 0.8704110252107304 0.9260886539245858 0.9672852462365374 0.9462088715992429 0.9883131800534827 0.9722729523411695 0.9208187706165162 1.0 13.790890800952328 -5.227364638320744 23.62324425768152 0.949084469201619 1.05717992234983 0.599509568860655 0.03539185365196893 218.7227955706777 151633.97514772954 0.009171354829118936 0.02426109016643622 5.924277070283682e-06 5.227364638320744 0.1080954531482109 DQDMS(ph)SPTTMK ddPTM_A459_Selumetinib_30min_R2 2 DQDMSSPTTMK 11 0 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 DQDMS(0.707)S(0.021)PT(0.271)T(0.001)MK;DQDMS(0.876)S(0.004)PT(0.093)T(0.027)MK 204.35 1.7745e-05 69957000.0 365170.0 316360.0 345580.0 352550.0 345890.0 273378.0 308170.0 311580.0 258193.0 313590.0 True False 344875.3132913325 340623.7947422709 323345.7590390555 304532.08181732724 302436.2059041662 311033.3380216002 322500.5156272701 312486.6462151539 309838.81451517873 304535.8418953313 1.1324621468032845 1.1185014959892405 1.061765856612008 0.9999876530854935 0.9931054552459322 1.0213357353467185 1.0589903428776481 1.0261079427312707 1.0174132955478852 1.0 18.216252508419416 -5.395508198381667 2.644264140536926 1.018952132363562 1.1289711349904352 0.8516990861063556 0.01802560735833486 0.110312659146107 1.4714902402968448 0.005565056468154124 0.014516412287022046 4.022460625384637e-06 5.395508198381667 0.11001900262687325 DQDNMQAELNR ddPTM_A459_Selumetinib_30min_R1 2 DQDNMQAELNR 11 0 P33176 P33176 KIF5B Kinesin-1 heavy chain 0 ; 211.86 0.0028655 30121000.0 3084.7 2149.18 2273.1 2833.1000000000004 2371.1000000000004 2165.59 2430.4 2042.78 1384.79 2045.16 False True 3156.5675082186553 1897.5530064733255 1964.4255052445378 2338.3522688735343 2156.6344236517066 2143.806130798396 2247.0729712737334 1988.598838515402 2349.8874889400836 2307.6762075453835 1.3678554633867877 0.8222787062885674 0.8512569912631058 1.013293052650909 0.9345481036725095 0.9289891379860038 0.9737384143956174 0.8617321754296821 1.0182916828871755 1.0 11.172225096800148 -4.7526594569742935 24.998048910883437 0.930498206761651 1.367856294421078 0.7938803721849627 0.06633327552431598 144.81993521497657 412298.28892996185 0.016237150610318305 0.18912572078495138 1.767423165750427e-05 4.7526594569742935 0.43735808765942696 DQDS(ph)SDDERALEDWVSSETSALPRPR ddPTM_A459_Selumetinib_30min_R1 1 DQDSSDDERALEDWVSSETSALPRPR 26 2 Q5TAQ8;V9GY54;Q5TAQ9-2;Q5TAQ9 Q5TAQ8 DCAF8 DDB1- and CUL4-associated factor 8 1 DQDS(0.674)S(0.326)DDERALEDWVSSETSALPRPR 42.341 0.032333 2228400.0 275.33 478.82 533.53 544.51 504.5 334.54 292.95 464.57 317.65 139.46 True False 281.7446533010805 422.7595318026209 461.0795564705112 449.4215502186043 458.86806407670946 331.1748313380168 270.85254564460183 452.2480944639661 539.0288497619255 157.36104945543576 1.7904345088958615 2.6865576536609543 2.9300742341648385 2.8559897876499565 2.9160206141524223 2.10455403344145 1.7212172045237062 2.8739519469971606 3.425427395326167 1.0 7.297934674002942 -6.765621516743607 24.989489809476265 2.310663829455336 2.6672139973152698 0.07630071745816103 0.678491923122106 358.7631965003423 2143696.8389008665 0.23835472942692232 0.21765761683562423 1.7154516550578297e-07 6.765621516743607 0.3565501678599339 DQGSTYS(ph)GDLESEAVSTPHSWEEELNHYALK ddPTM_A459_Selumetinib_30min_R1 1 DQGSTYSGDLESEAVSTPHSWEEELNHYALK 31 0 Q5VZL5-2;Q5VZL5-4;Q5VZL5;H7C1I7;Q5VZL5-3 Q5VZL5-2 ZMYM4 Zinc finger MYM-type protein 4 1 DQGS(0.022)T(0.018)Y(0.007)S(0.725)GDLES(0.102)EAVS(0.062)T(0.062)PHS(0.001)WEEELNHYALK 77.531 1.2614000000000003e-05 4140500.0 498.17 410.19 460.08 506.62 671.94 504.48 488.24 366.43 279.83 429.36 True False 509.77639172992116 362.1647641078424 397.60366303854096 418.1483274352154 611.1631456406424 499.4053892311913 451.41166371572115 356.711086067613 474.85107202543594 484.4725383205641 1.0522296960258541 0.7475444642606481 0.8206939126350562 0.8631001643245596 1.2615021436700093 1.030822904766475 0.9317590327834694 0.7362875247875983 0.9801403267799631 1.0 8.920271080489208 -4.46425256199811 21.991217648486142 0.9282202988761732 3.4661996923107923 0.0585908162544988 0.14654320963436174 920.1110318360021 385896.54333550076 0.03813953046731424 13280.115781439437 3.4335821140762254e-05 4.46425256199811 2.537979393434619 DQGT(ph)PEVQPTPAK ddPTM_A459_Selumetinib_30min_R2 2 DQGTPEVQPTPAK 13 0 J3KS37;O94762-4;O94762;J3KSV9 J3KS37 RECQL5 ATP-dependent DNA helicase Q5 1 DQGT(0.999)PEVQPT(0.001)PAK;DQGT(0.769)PEVQPT(0.231)PAK 155.26 0.00085502 14481900.0 96109.0 82498.0 90290.0 94761.0 100813.0 88874.0 91815.0 95505.0 80679.0 95382.0 True False 90767.6465348103 88825.33132712037 84480.83970031896 81854.38832815734 88147.96966034498 101115.58678215384 96084.5794279709 95782.90373829623 96817.05435960769 92628.07382780209 0.9799150817229518 0.9589461127330455 0.9120435760908832 0.8836887667590573 0.9516334089405148 1.0916300275241635 1.0373159611047784 1.034059111672332 1.0452236601572114 1.0 16.499161893054783 -6.643126306986034 6.344972748818187 1.0430957721783827 0.9321181885583173 0.7297297240745803 0.03186651821319462 0.11374550722260518 5.880351869567017 0.011082140079964775 0.011054695556064031 2.2744358545179174e-07 6.643126306986034 -0.11097758362006538 DQGTYEDYVEGLR ddPTM_A459_Selumetinib_30min_R1 2 DQGTYEDYVEGLR 13 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;G3V1Y7;F8VPF3;F8VZU9;F8W180;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 ; 188.96 0.0018157 18530400.0 4416.0 5416.8 3944.7 3526.6 3980.6000000000004 3949.2 3919.3999999999996 4357.2 2505.99 4304.3 False True 4518.884207959795 4782.5985377980005 3409.0314066860806 2910.7455124808143 3620.555432832009 3909.4746335867057 3623.756502472956 4241.632901819734 4252.4819997320565 4856.79883243247 0.9304244140778147 0.9847223866595053 0.701909122511197 0.5993135834746942 0.745461271456182 0.8049488497403324 0.7461203618882524 0.8733392195483136 0.8755730155704744 1.0 12.245790016141598 -8.447488151661172 1.2648701606545911 0.9955195459689684 0.7843584004969675 0.2739942285122313 0.10476076304533183 0.665481131830038 2.312150242538569 0.1114712023602281 0.034613209739895234 3.5687148525014335e-09 8.447488151661172 -0.21116114547200093 DQGTYEDYVEGLR ddPTM_A459_Selumetinib_30min_R2 2 DQGTYEDYVEGLR 13 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;G3V1Y7;F8VPF3;F8VZU9;F8W180;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 ; 191.48 0.0023786 16042200.0 46139.0 32525.0 37874.0 48927.0 50247.0 41219.0 41751.0 43961.0 37858.0 41262.0 False True 43574.77908905108 35019.5629156415 35437.22807409328 42263.05819621728 43934.52264612057 46896.54310117247 43692.504228037 44088.9192318647 45430.65784090065 40070.65884844904 1.0874485307030999 0.8739452737248156 0.8843684903739708 1.054713334164534 1.0964262607282056 1.1703461946692606 1.090386469393631 1.1002793689670312 1.1337636851124315 1.0 15.290258610545408 -5.933122607837395 4.772829160860549 1.1045577680396421 0.9420041963498819 0.4929177526689885 0.06761577785841288 0.1545199026935196 6.866872807638803 0.019021084968439243 0.028579153807102162 1.1664802557228181e-06 5.933122607837395 -0.16255357168976026 DQHLNNS(ph)SSSPQR ddPTM_A459_Selumetinib_30min_R2 1 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.253)S(0.249)S(0.249)S(0.249)PQR 124.5 0.0014869000000000002 450770.0 527.08 490.62 1071.6 717.13 707.8 0.0 681.82 849.99 975.68 704.46 True False 497.78700366841605 528.2489764080568 1002.6544226698627 619.4556568817485 618.8798361877157 0.0 713.5259810006996 852.46333017658 1170.843262776954 684.1204093931071 0.7276306872791735 0.7721578967022398 1.4656110370385407 0.9054775276055225 0.9046358326551501 0.0 1.0429830351555782 1.246072063443937 1.711457875983594 1.0 9.418106460421054 -7.698426518552113 3.719795930093677 1.3711536512123519 0.8161246959198343 0.27621648047028313 0.3732161377393134 0.30525200115268636 8.422195852678092 0.20907240198160681 0.10798885121204212 2.0025044112397066e-08 7.698426518552113 -0.5550289552925176 DQHLNNSS(ph)SSPQR ddPTM_A459_Selumetinib_30min_R1 2 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.033)S(0.497)S(0.235)S(0.235)PQR;DQHLNNS(0.022)S(0.557)S(0.314)S(0.107)PQR 133.9 0.00084429 26954600.0 2939.01 3890.4 3515.4 4343.9 4042.3 2884.1 4065.9 3289.1000000000004 1409.72 2429.89 True False 3007.4832146820477 3434.9101594021067 3038.0279887099773 3585.319410101918 3676.6746787260295 2855.0885725532785 3759.2058895251284 3201.8623834974924 2392.1918781249233 2741.790050632934 1.0969049997054952 1.25279838936215 1.1080454493620537 1.307656437543151 1.340976008676259 1.041322829183872 1.3710772233115833 1.1677999862747888 0.8724927269951589 1.0 11.4209023873229 -8.167976713500149 5.232809745373772 0.9388137951035345 1.2186336449666346 0.5147971267965166 0.10715293927870592 0.1600265266687417 6.73264956804291 0.07345689545554258 0.026326719178752553 6.792400519132703e-09 8.167976713500149 0.27981984986310016 DQHLNNSS(ph)SSPQR ddPTM_A459_Selumetinib_30min_R2 4 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.056)S(0.456)S(0.244)S(0.244)PQR;DQHLNNS(0.041)S(0.46)S(0.249)S(0.249)PQR;DQHLNNS(0.131)S(0.29)S(0.29)S(0.29)PQR;DQHLNNS(0.034)S(0.322)S(0.322)S(0.322)PQR 128.64 0.0010852 79479910.0 21457.530000000002 20265.33 26714.329999999998 28794.26 27901.3 17482.58 21300.4 30133.95 23182.510000000002 23285.980000000003 True False 20265.006383898355 21819.615647693696 24995.55909216328 24872.432115130945 24396.089253213217 19890.64670393985 22290.910805941883 30221.634805556037 27819.659773449675 22613.65325315803 0.8961403165173375 0.9648868054809566 1.1053304307950602 1.0998856238169952 1.0788212315852268 0.8795857299687785 0.9857279828427954 1.3364331038080077 1.2302151917698048 1.0 14.464906458965833 -7.74227552539011 24.999886520856744 1.212493123500906 1.006140119774456 0.3848375604376574 0.10722523345431965 220.85180485883043 288109.2021564342 0.051649298217959966 0.02976017595714386 1.8101913054954582e-08 7.74227552539011 -0.20635300372645005 DQHLNNSSS(ph)SPQR ddPTM_A459_Selumetinib_30min_R1 1 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.027)S(0.006)S(0.483)S(0.483)PQR 132.31 0.0014362 11412000.0 1424.8 1632.4 1569.5 1844.3 2384.4 1494.3 2166.4 1611.8 447.97 1272.3 True False 1457.9950678218115 1441.2778491178294 1356.3705206463878 1522.2276267987218 2168.7314410000117 1479.268698715845 2002.9867038213542 1569.0498281357395 760.1723715657163 1435.6120982514774 1.0155912377707013 1.003946575034616 0.9448029326991582 1.0603335181228544 1.5106667348662266 1.0304097468372826 1.3952144219604434 1.0929483180357593 0.5295109817558504 1.0 10.487450270921098 -8.125418183390781 7.3917170753038715 0.7686141892527436 1.1396462703895065 0.3493315450221842 0.2009823262019202 0.2824090808019115 15.525948331993552 0.13828591078913288 0.05173943279048542 7.491724815998836e-09 8.125418183390781 0.3710320811367629 DQHLNNSSS(ph)SPQR ddPTM_A459_Selumetinib_30min_R2 3 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.022)S(0.007)S(0.885)S(0.086)PQR;DQHLNNS(0.063)S(0.309)S(0.477)S(0.151)PQR;DQHLNNS(0.099)S(0.198)S(0.352)S(0.352)PQR 228.49 5.6025e-13 24304950.0 17941.929999999997 16916.269999999997 20755.850000000002 22359.0 24411.9 16934.699999999997 17026.61 19377.1 19122.65 20156.85 True False 16944.789357836493 18213.693514618888 19420.441208260785 19313.66562857363 21345.058876845003 19267.30120709928 17818.381102587646 19433.48415294841 22947.7143314834 19574.869366714167 0.8656399713527612 0.9304630939499462 0.9921108971119891 0.9866561695382399 1.090431740665454 0.9842876009104875 0.9102681999445004 0.9927772078006215 1.1723048517761525 1.0 14.256715059243415 -4.9363651063986955 1.2860722724659184 1.0167715407165752 0.823482994264792 0.3661234678105757 0.06603004866675544 1.2717521938497833 2.25217453211892 0.020805328090919117 0.30258250437668593 1.157803594671073e-05 4.9363651063986955 -0.19328854645178317 DQHLNNSSSS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.001)S(0.002)S(0.083)S(0.914)PQR 230.67 4.011e-13 13553000.0 1189.9 1089.9 1165.5 1555.7 1277.3 1112.8 1458.7 963.12 565.61 767.07 True False 1217.6223548576463 962.2940013192369 1007.2315016332369 1284.0261991057698 1161.7684405256307 1101.6062423415592 1348.669084593893 937.5749289453368 959.7988594800657 865.5309063945302 1.4067924621314727 1.1117962330516706 1.1637152344206598 1.4835128238857818 1.3422610699889532 1.272752057959927 1.5581986438958386 1.0832367995395038 1.1089134453652494 1.0 9.757441526069154 -7.913933697659844 14.010576377025124 1.0683281019813247 1.3227232166509417 0.476726765439236 0.1293593773879341 0.826548067207576 131.49592350317556 0.07292876664125449 0.0350306476765285 1.2191757123481856e-08 7.913933697659844 0.25439511466961706 DQHLNNSSSS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 DQHLNNSSSSPQR 13 0 A0A5H1ZRS1;A0A4W8VX11;E7EV93;E9PGW9 A0A5H1ZRS1 PCM1 1 DQHLNNS(0.022)S(0.244)S(0.135)S(0.599)PQR;DQHLNNS(0.003)S(0.031)S(0.031)S(0.934)PQR 162.26 0.00024038 64273000.0 66582.0 51234.0 73693.0 77617.0 84185.0 57283.0 51250.0 62177.0 56362.0 56873.0 True False 62881.638988864055 55163.48305672488 68951.67261087167 67045.43070320666 73608.92767655109 65173.2132866994 53633.2265499484 62357.924776043525 67635.97488585877 55230.9287161999 1.1385222093942466 0.9987788425608125 1.2484250077556147 1.2139109781715733 1.3327483239469897 1.1800129891276534 0.9710723284328392 1.1290399460140381 1.2246032514390857 1.0 15.753188766291958 -7.041063536234227 24.957286102762012 1.0895908154716591 1.1885516533582325 0.19664784362230214 0.1026620652753839 966.0002876675692 587105.4290490396 0.041825058242365466 0.032401351936153594 9.09780164254136e-08 7.041063536234227 0.0989608378865734 DQLIYNLLK ddPTM_A459_Selumetinib_30min_R1 2 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-4;P00338-2;F5GYU2;F5GXY2;F5GXH2;F5H5J4;F5H6W8;F5GZQ4;F5H8H6;F5GXC7;F5GWW2;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 ; 143.04 0.028643 24060000.0 7293.3 7441.8 6655.5 6548.200000000001 6539.3 5791.200000000001 6785.7 6659.4 5388.6 6733.1 False True 7463.2196997086085 6570.510596401044 5751.719656044621 5404.679794937582 5947.8214696071855 5732.945785988888 6273.849185801591 6482.771079220216 9144.060632227645 7597.3589709479065 0.9823439603482943 0.8648414036412517 0.7570683020295658 0.7113892887784993 0.7828801419482077 0.7545971972512443 0.825793438192485 0.8532927171152707 1.2035841227450597 1.0 12.891282274047368 -8.14614944754451 5.270075025098677 1.098325327290956 0.8066118080831005 0.6489269057378803 0.08415996541005236 0.13402804763310577 5.141151810890735 0.06188111427873098 0.02235395767879944 7.142504989794757e-09 8.14614944754451 -0.2917135192078556 DQMEGS(ph)PNSSESFEHIAR ddPTM_A459_Selumetinib_30min_R2 2 DQMEGSPNSSESFEHIAR 18 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 DQMEGS(0.972)PNS(0.027)SESFEHIAR;DQMEGS(0.994)PNS(0.006)SESFEHIAR 167.34 8.720499999999999e-08 29428000.0 41300.0 35704.0 54871.0 56057.0 59631.0 51737.0 47417.0 50994.0 44576.0 58385.0 True False 39004.711336999266 38442.38199354541 51340.65959902762 48421.93989628125 52139.620672096215 58863.30212827486 49621.984455003025 51142.384097488815 53492.44555750405 56699.27334755214 0.6879225964310035 0.6780048442226654 0.9054906098059216 0.8540134121202412 0.9195818146115134 1.0381667815645146 0.8751784903985077 0.9019936425639707 0.9434414658122503 1.0 15.79104262539419 -5.290265433263085 3.8652358800596622 0.9274768824398303 0.6775953506663882 0.7833912962439663 0.05193773946769976 0.09545621610895477 3.1693443458411616 0.014225506491843292 0.03557994279643592 5.125480277676159e-06 5.290265433263085 -0.24988153177344208 DQMEGSPNS(ph)SESFEHIAR ddPTM_A459_Selumetinib_30min_R1 1 DQMEGSPNSSESFEHIAR 18 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 DQMEGS(0.245)PNS(0.727)S(0.028)ESFEHIAR 195.36 1.8733e-10 9625300.0 1601.1 2371.2 2047.2 2023.9 2551.9 1887.0 2347.4 2194.0 673.81 1527.7 True False 1638.4025148017288 2093.5788016590277 1769.2014844646596 1670.4638583082651 2321.0810955745374 1868.0184932589168 2170.3337280974174 2135.8079928836164 1143.4063568647346 1723.7951760581468 0.9504624085027967 1.2145171484041835 1.0263408953901036 0.9690616852334881 1.3464947157366003 1.0836661566315378 1.2590438575541112 1.2390149494255063 0.663307551120659 1.0 10.751372646072706 -8.253597130895377 24.9925626758364 0.8316537670374231 1.1388309993778336 0.41373338924720204 0.14492171916980637 493.2330140785643 1571903.1231596419 0.09880474745231994 0.03581843357574779 5.577028567479758e-09 8.253597130895377 0.3071772323404105 DQMEGSPNSSES(ph)FEHIAR ddPTM_A459_Selumetinib_30min_R1 2 DQMEGSPNSSESFEHIAR 18 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 DQMEGS(0.003)PNS(0.031)S(0.031)ES(0.935)FEHIAR;DQMEGS(0.011)PNS(0.224)S(0.224)ES(0.541)FEHIAR 263.47 6.4163999999999994e-43 10758600.0 1657.19 2415.33 1954.7 2059.19 2171.24 1824.78 2474.06 1975.1 518.4100000000001 1175.33 True False 1695.7993026695874 2132.5420407435467 1689.2624763985302 1699.5911222836085 1974.8517253635553 1806.4243699676767 2287.439662322867 1922.7139319710247 879.7039068316694 1326.1950541836893 1.2786952396782991 1.6080153775390054 1.2737662314977636 1.2815544115641082 1.4891110618559293 1.36211062186443 1.7248138990616664 1.4497972420463516 0.6633292018821109 1.0 10.373077264492938 -8.252244314376597 24.964029459171943 0.8316646002653364 1.4380988158529724 0.695877955068809 0.15911787766344768 300.77852883748784 816600.66584883 0.10928140898619092 0.04002489161434024 5.594427958142434e-09 8.252244314376597 0.606434215587636 DQMSHLFNVAHTLR ddPTM_A459_Selumetinib_30min_R1 2 DQMSHLFNVAHTLR 14 0 P27708;F8VPD4;H7BZB3 P27708;H7BZB3 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 ; 140.27 0.00030462 16772800.0 8299.3 11220.2 11698.2 13430.2 10908.8 10314.0 9090.0 8502.1 4644.5 7167.8 False True 8492.657542373354 9906.533767870535 10109.648693612973 11084.867686077203 9922.100966105065 10210.250524362726 8404.333981599015 8276.596689287053 7881.3772791413985 8087.856950284474 1.050050414414741 1.2248651068837328 1.2499786724414539 1.3705568427106412 1.2267898687001475 1.2624172988128333 1.039129899707661 1.0233361866020567 0.974470410095988 1.0 12.981541765219005 -7.328606853725613 4.390010294878724 1.0054267359489688 1.2378095411032102 0.6794866365427978 0.07463633745527729 0.13951621845536488 5.3134383885732746 0.03411560736071458 0.02272583196677591 4.692379688992186e-08 7.328606853725613 0.23238280515424137 DQPAFTPSGILT(ph)PHALGSR ddPTM_A459_Selumetinib_30min_R1 2 DQPAFTPSGILTPHALGSR 19 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 DQPAFTPSGILT(1)PHALGSR;DQPAFTPSGILT(1)PHALGSR 148.84 4.6614e-05 27303000.0 7136.1 7329.0 8040.8 8436.2 8937.7 6493.3 8115.7 7612.8 3516.5 6099.6 True False 7302.357245566562 6470.917272840338 6948.903524952837 6962.976037086904 8129.286613079096 6427.983297444685 7503.526215012447 7410.8838141405595 5967.243665001764 6882.5430751353515 1.060996955027841 0.9401927749959025 1.0096418502714828 1.0116865177701733 1.18114576608287 0.9339546774021859 1.090225826863406 1.0767653370618124 0.8670114519965301 1.0 12.748726018773107 -8.25251856512434 24.99252816538829 0.9335057216596719 1.036022551323028 0.23765564708635123 0.07484303723358353 827.9090263778232 2319482.85097148 0.05101290904005394 0.018667158357369745 5.59089627220143e-09 8.25251856512434 0.10251682966335596 DQPAFTPSGILT(ph)PHALGSR ddPTM_A459_Selumetinib_30min_R2 4 DQPAFTPSGILTPHALGSR 19 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 DQPAFTPSGILT(1)PHALGSR;DQPAFTPS(0.009)GILT(0.991)PHALGSR;DQPAFTPS(0.005)GILT(0.993)PHALGS(0.001)R;DQPAFTPS(0.009)GILT(0.991)PHALGSR 188.27 6.1066e-15 25843600.0 116365.5 121021.7 124903.3 149231.0 152075.0 106455.0 107747.9 110075.0 108155.9 129109.0 True False 109898.37135800449 130303.67524390142 116867.15766243065 128905.48036216632 132969.97893225052 121118.20994772606 112758.39084841331 110395.30002610272 129790.10212833922 125381.28770453212 0.876513340786434 1.0392593474631493 0.9320940931619279 1.0281078039806 1.0605249105879464 0.9659990909739878 0.8993239175700176 0.8804766807488474 1.0351632568505493 1.0 16.935962526322626 -9.5446626949073 15.05958360087364 0.999999998647286 0.9693580344369654 0.019735347308524998 0.06618470299593997 0.0 0.0 0.06527801035520399 0.01583224304262762 2.853233438469602e-10 9.5446626949073 -0.030641964210320505 DQPDGSS(ph)LSPAQS(ph)PSQSQPPAASSLR ddPTM_A459_Selumetinib_30min_R2 1 DQPDGSSLSPAQSPSQSQPPAASSLR 26 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 DQPDGS(0.161)S(0.482)LS(0.365)PAQS(0.968)PS(0.022)QS(0.001)QPPAASSLR 82.581 0.00047351 5137800.0 13833.0 10744.0 14409.0 15395.0 17120.0 16713.0 17704.0 16064.0 13062.0 14607.0 True False 13064.217237886463 11568.030252595008 13481.940627333 13298.174442143703 14969.232545258124 19015.064044491526 18527.271079810467 16110.743580461638 15674.76498277364 14185.25795645618 0.9209714252634021 0.8154966436355862 0.9504191371575956 0.9374644072715833 1.0552668545900592 1.3404806668205242 1.3060933496368385 1.1357384990753099 1.1050038730976715 1.0 13.792104765559417 -6.409749483388478 3.0139810574472943 1.1942713805297922 0.9002546792316668 0.6213006093609836 0.09858466245208769 0.16956021196714932 2.9482816862788734 0.033815567862309416 0.03850576667491348 3.892696249054593e-07 6.409749483388478 -0.2940167012981254 DQPDGSSLS(ph)PAQSPSQSQPPAASSLREPGLESK ddPTM_A459_Selumetinib_30min_R2 1 DQPDGSSLSPAQSPSQSQPPAASSLREPGLESK 33 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DQPDGS(0.055)S(0.189)LS(0.461)PAQS(0.251)PS(0.041)QS(0.003)QPPAASSLREPGLESK 101.74 1.5585e-11 17913000.0 32502.0 34325.0 39620.0 40718.0 42406.0 27185.0 22352.0 23427.0 21421.0 35966.0 True False 30695.6689558148 36957.61712772928 37070.89233499437 35172.13815753216 37078.57916554997 30929.48698914029 23391.412289647757 23495.16869145137 25705.798552747976 34927.568129109524 0.8788378521616066 1.058121681736206 1.0613648278621077 1.0070022060373223 1.061584907042175 0.8855322212760317 0.6697120224111096 0.6726826386710244 0.7359744731647695 1.0 15.092078576527554 -7.003343193112216 4.101212911385756 0.7439055033428207 1.016855522727157 0.559585423895582 0.10081447983761713 0.13796081398643462 5.427418067370007 0.03696697868312129 0.030342148376990306 9.923315669927667e-08 7.003343193112216 0.2729500193843363 DQPDGSSLSPAQS(ph)PSQSQPPAASSLREPGLESK ddPTM_A459_Selumetinib_30min_R2 1 DQPDGSSLSPAQSPSQSQPPAASSLREPGLESK 33 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 DQPDGS(0.035)S(0.05)LS(0.421)PAQS(0.473)PS(0.016)QS(0.005)QPPAASSLREPGLESK 88.395 1.0812e-08 15116000.0 44320.0 45078.0 44616.0 49225.0 53266.0 34517.0 31791.0 30691.0 25578.0 47351.0 True False 41856.87182701714 48535.33765138473 41745.455134227865 42520.47008213861 46574.24887591817 39271.40343587109 33269.3444926714 30780.30572883142 30694.314709032617 45983.85359732706 0.910251502484998 1.055486520907982 0.9078285499903043 0.9246826169568839 1.0128391866362725 0.8540259322275211 0.7235005744408788 0.669372036505888 0.6675020101146287 1.0 15.488839753234771 -7.028018313933045 3.5137537665935175 0.7391796784889372 0.9618128847408196 0.4617861766495901 0.09860686895966293 0.18607505960292797 4.796339052310225 0.03709116887145791 0.029679326892872025 9.375224713422901e-08 7.028018313933045 0.22263320625188243 DQPPFGDS(ph)DDSVEADK ddPTM_A459_Selumetinib_30min_R2 1 DQPPFGDSDDSVEADK 16 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 DQPPFGDS(0.655)DDS(0.345)VEADK 85.49600000000002 0.037889 0.0 4030.9 1321.7 3895.9 4805.2 6333.5 4636.0 4294.7 4663.1 4508.7 3682.6 True False 3806.8787149711934 1423.0701400646703 3645.242035535198 4150.7234705676465 5537.829107791607 5274.5669185821025 4494.412059786607 4676.668848982236 5410.5659836036975 3576.2737694561206 1.0644819050165009 0.3979197991548311 1.019284951467674 1.1606279994607036 1.5484913809139953 1.474877836151861 1.2567304265607486 1.3076931886267376 1.51290598326496 1.0 11.804241466015162 -5.701926275469036 2.460062568738209 1.3622209793727147 0.7303882299074086 0.5453077270306577 0.2173568151394302 0.18508323225940143 2.272941583136199 0.06005576489726471 0.11624822784883054 1.9864320995028502e-06 5.701926275469036 -0.6318327494653061 DQPPFGDSDDSVEADKS(ph)SPGIHLER ddPTM_A459_Selumetinib_30min_R2 2 DQPPFGDSDDSVEADKSSPGIHLER 25 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 DQPPFGDSDDSVEADKS(0.5)S(0.5)PGIHLER;DQPPFGDSDDSVEADKS(0.5)S(0.5)PGIHLER 128.01 2.8769e-08 8428900.0 37166.0 34068.0 40805.0 44766.0 44100.0 36798.0 41702.0 35150.0 30766.0 40676.0 True False 35100.46250728606 36680.906054114515 38179.65072512478 38668.79357434264 38559.76374099783 41866.59048101473 43641.225630945344 35252.28068060424 36920.05967386416 39501.57819105989 0.8885838013234139 0.9285934318041056 0.9665348189497328 0.9789176874734153 0.9761575488071205 1.0598713367480113 1.1047970139284802 0.8924271458243317 0.9346477119291405 1.0 15.269622673419748 -5.0826661047586015 1.1503896811480927 0.9963974307465795 0.8679316618635885 0.27737190872270323 0.05560932903395897 1.5048619257989289 2.376453389473678 0.019694504455253187 0.20587138157695756 8.266732700883352e-06 5.0826661047586015 -0.128465768882991 DQQEAALVDMVNDGVEDLR ddPTM_A459_Selumetinib_30min_R1 10 DQQEAALVDMVNDGVEDLR 19 0 P09211;A8MX94 P09211 GSTP1 Glutathione S-transferase P 0 ;;;;;;;;; 254.94 3.8834999999999994e-36 158459700.0 16041.720000000001 16781.11 13888.359999999999 15702.9 15622.190000000002 14210.48 14849.500000000002 14425.949999999999 9536.41 12315.28 False True 16415.46086424657 14816.369839873605 12002.396995300707 12960.683294939892 14209.165672821662 14067.535473283502 13729.390259598964 14043.326943910384 16182.591258171338 13896.06614898566 1.1813027290061375 1.0662276417671719 0.8637262421334126 0.9326872192448475 1.0225315222653037 1.0123394147998035 0.9880055342569838 1.0105973009444456 1.164544777253567 1.0 13.762388906340389 -8.042947242049975 23.55613226954014 1.084038776358562 1.0034491143605249 0.09899580039229439 0.08621379853749721 550.3629135462375 301863.1823245542 0.06042208812024124 0.022843011424528357 9.058426356783593e-09 8.042947242049975 -0.08058966199803708 DQQEAALVDMVNDGVEDLR ddPTM_A459_Selumetinib_30min_R2 4 DQQEAALVDMVNDGVEDLR 19 0 P09211;A8MX94 P09211 GSTP1 Glutathione S-transferase P 0 ;;; 224.67 9.778e-19 15133500.0 37664.4 36178.0 36136.4 36322.5 37914.5 31809.4 34409.5 32075.6 28998.4 36587.3 False True 35571.163430539375 38952.73626939522 33811.42336633746 31375.31284019257 33151.34155006943 36190.856113016736 36009.60993113075 32168.93468559858 34798.890282993634 35530.929583778256 1.0011323612197156 1.0963050144114213 0.951605369249167 0.8830422735271485 0.9330277011723546 1.0185732976020918 1.0134722156993898 0.9053783580231853 0.9793971250017947 1.0 15.116787813458195 -5.279108115796081 24.30382386775943 0.9573922384591359 1.0487186864894278 0.35367051344620015 0.047515388499713034 536.0158884767346 737303.7656505127 0.012966079065275518 0.02708514700410462 5.258863328891441e-06 5.279108115796081 0.09132644803029188 DQQNLPYGVTPAS(ph)PSGHSQGR ddPTM_A459_Selumetinib_30min_R1 2 DQQNLPYGVTPASPSGHSQGR 21 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 DQQNLPYGVTPAS(0.984)PS(0.014)GHS(0.001)QGR;DQQNLPYGVT(0.001)PAS(0.993)PS(0.006)GHSQGR 248.33 7.7249e-39 15735100.0 3786.8999999999996 4579.4 4977.5 4994.2 6442.1 3870.6 5284.7 4348.8 1612.75 3202.1000000000004 True False 3875.127401975308 4043.2417190946985 4301.582839450396 4122.056722744767 5859.413192445129 3831.6652782236115 4886.070824263623 4233.455697106778 2736.7189594004276 3613.120726095305 1.0725153394370948 1.1190441797011927 1.1905450068088677 1.140857733585744 1.6217042375933532 1.0604863686258519 1.3523131925746619 1.1716895221715626 0.7574391134054345 1.0 11.81902974536357 -8.155361748552274 5.72897536707948 0.8827796885542467 1.2253642198379775 0.40120372812678784 0.16545883570230108 0.21275314666356035 9.36802633714649 0.11471181837667094 0.04187205457157183 6.992593005498345e-09 8.155361748552274 0.3425845312837308 DQQNLPYGVTPAS(ph)PSGHSQGR ddPTM_A459_Selumetinib_30min_R2 3 DQQNLPYGVTPASPSGHSQGR 21 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 DQQNLPYGVTPAS(0.931)PS(0.006)GHS(0.063)QGR;DQQNLPYGVTPAS(0.996)PS(0.003)GHS(0.001)QGR;DQQNLPYGVTPAS(0.852)PS(0.14)GHS(0.007)QGR 191.15 1.0470999999999999e-16 54175900.0 46615.2 39149.2 48831.2 73306.0 74474.0 49126.6 42896.3 48891.8 38533.1 47093.3 True False 44024.513799430715 42151.81775548142 45689.4537553906 63321.59634009652 65117.91031399259 55893.34322312674 44891.06294740591 49034.06704352681 46240.79670477068 45733.59406591209 0.962629653291228 0.9216817225152139 0.9990348383628482 1.3845751166819795 1.423852895098152 1.2221506829874826 0.9815774129343102 1.0721673650415058 1.0110903734818566 1.0 15.480966680223307 -7.267766676128606 24.286750007145702 1.0222227317299712 1.1577690593961125 0.1499831968402605 0.15816575486422338 847.1427626423482 3251657.8722633817 0.07656290620137801 0.05309570824919195 5.398005514297e-08 7.267766676128606 0.13554632766614128 DQS(ph)PFSK ddPTM_A459_Selumetinib_30min_R1 4 DQSPFSK 7 0 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 DQS(0.928)PFS(0.072)K;DQS(0.934)PFS(0.066)K;DQS(0.98)PFS(0.02)K;DQS(0.934)PFS(0.066)K 140.11 0.003069 1089930000.0 39172.0 43760.0 40770.3 42663.0 35661.7 36656.299999999996 39432.7 36486.2 22236.9 33746.5 True False 40084.631384556444 38636.55885652793 35233.917195227405 35212.7079336951 32436.105531584486 36287.570903257416 36458.25969155107 35518.46745211952 37734.39518108283 38078.19199374632 1.0526926118535158 1.0146636915658527 0.9253043632169816 0.9247473708698716 0.8518289297168193 0.9529751546296373 0.9574577411012243 0.9327771512353531 0.9909712936811719 1.0 15.216677358626493 -5.117065775652998 3.44164713891803 0.9367157407470159 1.047016217000472 0.47386322594061847 0.039116970783705275 0.2008988175706647 4.259308134800963 0.010438715208553277 0.035848170891539397 7.637201063239563e-06 5.117065775652998 0.11030047625345607 DQS(ph)PFSK ddPTM_A459_Selumetinib_30min_R2 5 DQSPFSK 7 0 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 DQS(0.981)PFS(0.019)K;DQS(0.721)PFS(0.279)K;DQS(0.935)PFS(0.065)K;DQS(0.981)PFS(0.019)K;DQS(0.981)PFS(0.019)K 157.34 0.0012469000000000002 1409041000.0 4453480.0 3776760.0 3703800.0 3991850.0 4060420.0 2811540.0 3323820.0 3545470.0 2728659.0 3497510.0 True False 4205973.410292967 4066425.347802561 3465501.5403925255 3448153.1436746586 3550313.7389846393 3198804.114381004 3478384.216024384 3555786.730715844 3274467.045102603 3396527.7986776945 1.2383156151203587 1.197230109344509 1.0203071329908393 1.0151994472169674 1.0452773978080836 0.9417865255294933 1.0241000286759192 1.0468887468255523 0.9640630782934821 1.0 21.69562923120965 -5.227747098785438 3.2932186846258125 1.007080537376414 1.2319613589323903 0.8812714374210218 0.03111177232889704 0.07396189781753484 1.6386205211857992 0.008209248857914606 0.02464365042309011 5.919062165508634e-06 5.227747098785438 0.22488082155597633 DQS(ph)PPPS(ph)PPPSYHPPPPPTK ddPTM_A459_Selumetinib_30min_R2 1 DQSPPPSPPPSYHPPPPPTK 20 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 2 DQS(1)PPPS(0.993)PPPS(0.002)Y(0.005)HPPPPPTK 97.124 0.0038144 6380100.0 11013.0 10815.0 15516.0 22647.0 24885.0 14770.0 12430.0 15407.0 15307.0 21647.0 True False 10400.941548532031 11644.475724294027 14517.717452543478 19562.43953174592 21758.72382527735 16804.43343128939 13008.019629577739 15451.831819233848 18368.827713314655 21021.994864339496 0.49476472692777557 0.5539186837138395 0.6905965654653689 0.9305700842373679 1.035045625578931 0.7993738719723249 0.6187814103048705 0.7350316617879803 0.8737908952910306 1.0 14.359611958665608 -5.431678953792075 2.9147021039130556 0.8395016461508948 0.5201038065234922 0.5582454161999337 0.11764539442527829 0.22626441888214993 3.675476356117956 0.03608009400293382 0.0863547362097 3.7010167123811384e-06 5.431678953792075 -0.31939783962740265 DQS(ph)PSRAPGLR ddPTM_A459_Selumetinib_30min_R1 4 DQSPSRAPGLR 11 1 P09601 P09601 HMOX1 Heme oxygenase 1 1 DQS(0.984)PS(0.016)RAPGLR;DQS(0.836)PS(0.164)RAPGLR;DQS(0.852)PS(0.148)RAPGLR;DQS(0.984)PS(0.016)RAPGLR 131.32 0.010562 528262000.0 25993.899999999998 23466.0 32960.2 32156.899999999998 29468.799999999996 25900.100000000002 24422.2 26858.800000000003 18315.8 19492.4 True False 26599.507294675303 20718.589810952573 28484.385877418943 26541.30107477298 26803.35224313922 25639.568509409248 22580.01379157398 26146.417374321987 31080.5748668959 21994.439412054606 1.2093741875547315 0.9419921746037878 1.295072147272249 1.2067277813967083 1.218642209559975 1.165729575055995 1.0266237465092398 1.188773984391336 1.4131105723868282 1.0 14.424851210269848 -5.270593982064129 24.98691337820422 1.1910906149579477 1.0756831732742762 0.11359863209614518 0.1269128609155061 1242.172719936805 3390437.4872511057 0.03249082740277084 0.06904903515996666 5.362978031258244e-06 5.270593982064129 -0.11540744168367145 DQS(ph)TPIIEVEGPLLSDTHVTFK ddPTM_A459_Selumetinib_30min_R1 1 DQSTPIIEVEGPLLSDTHVTFK 22 0 P49116;P49116-2 P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 1 DQS(0.5)T(0.5)PIIEVEGPLLSDTHVTFK 101.71 7.530199999999999e-05 2006300.0 1260.1 1254.2 1588.0 1616.0 2082.8 1559.9 2062.4 1290.3 513.54 1011.9 True False 1289.457878272223 1107.3576809382391 1372.358322259613 1333.7959360769585 1894.4111077482069 1544.2088222758791 1906.8315075522335 1256.0770525149183 871.4398725223963 1141.7872217406816 1.1293329034690143 0.9698459221237791 1.201938764183593 1.168165057972496 1.6591629961142256 1.352448856382975 1.6700410297509056 1.1000973111259724 0.763224404625816 1.0 10.157078106342789 -7.9996310342653505 24.999957966505452 0.8982950093579334 1.3062323890067558 0.3878171280850161 0.21494876294550283 13.33825529485871 903783.7384990755 0.13004998727264586 0.06153792913879579 1.0008499359914927e-08 7.9996310342653505 0.4079373796488224 DQSEQETSDADQHVTSNAS(ph)DSESSYR ddPTM_A459_Selumetinib_30min_R2 1 DQSEQETSDADQHVTSNASDSESSYR 26 0 A0A590UJ08;A0A0C4DFT3;A0A590UJD9;Q12959-4;Q12959-2 A0A590UJ08 DLG1 Disks large homolog 1 1 DQSEQETSDADQHVT(0.005)S(0.15)NAS(0.44)DS(0.257)ES(0.104)S(0.043)YR 92.266 1.6340999999999998e-05 6637800.0 15822.0 11859.0 20797.0 22326.0 22805.0 19790.0 21887.0 18805.0 20604.0 19008.0 True False 14942.676580484325 12768.547167304932 19458.943662061523 19285.16028550182 19940.032020713283 22515.892864266574 22904.78886826773 18859.719436664665 24725.375723860674 18459.18965128494 0.809497971621098 0.6917176435432589 1.0541602329063773 1.0447457688999573 1.0802225014967144 1.2197660509273356 1.2408339315519916 1.0216981239667713 1.3394616010210147 1.0 14.1720516003699 -5.457036143255418 1.444167843969081 1.155509922538141 0.7221216050262466 0.6494103003799042 0.10909746082360817 0.28036452026924646 1.0520530781686672 0.032429188404812896 0.1208398596596203 3.4911126021069414e-06 5.457036143255418 -0.43338831751189455 DQSPPEDSGESEADLECSFAAIHS(ph)PAPPPDPAPR ddPTM_A459_Selumetinib_30min_R2 1 DQSPPEDSGESEADLECSFAAIHSPAPPPDPAPR 34 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 DQSPPEDSGESEADLECS(0.236)FAAIHS(0.764)PAPPPDPAPR 79.553 3.1584e-06 1765100.0 4216.5 2619.9 4003.5 3399.8 4046.8 3760.4 3936.2 3274.9 2355.3 3980.1 True False 3982.1638099868615 2820.8379056937492 3745.91916868122 2936.7413750178753 3538.4048051489804 4278.360966487517 4119.241099432334 3284.4294168111196 2826.425812580518 3865.184171458288 1.030264958495998 0.7298068553948054 0.9691437723310167 0.7597933875191976 0.915455680295302 1.1068970524303223 1.0657295789034014 0.8497471973171057 0.7312525580156615 1.0 11.916321443163884 -4.465490456297658 22.564331102961898 0.9061857615778276 3.477235796436058 0.08066125285972159 0.1284200875012833 1066.1923681085755 448992.03798697604 0.03237392661127365 9628.572513675696 3.423809114282499e-05 4.465490456297658 2.57105003485823 DQT(ph)PDENDQVVVK ddPTM_A459_Selumetinib_30min_R1 1 DQTPDENDQVVVK 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 DQT(1)PDENDQVVVK 195.2 0.00046799 2624200.0 565.43 778.84 933.4 917.64 814.31 775.68 896.83 617.16 326.92 736.02 True False 578.6034188647441 687.6530507271071 806.6494067991956 757.3914002361756 740.655804278107 767.8773634610895 829.1813910580246 600.7909119817923 554.7593627079134 830.4953364419177 0.6966967705606253 0.8280035065256498 0.9712870998832035 0.9119755006464689 0.8918241581599852 0.9246016561042935 0.9984178774687376 0.7234127461278161 0.6679861263094661 1.0 9.697828256684822 -14.054040707835334 18.122926652348085 0.9977239208851663 0.863670524174302 0.0 0.11928097152394927 0.0 0.0 0.0 0.02825319817501144 8.829971303444557e-15 14.054040707835334 -0.13405339671086425 DQTAS(ph)APATPLVNK ddPTM_A459_Selumetinib_30min_R1 1 DQTASAPATPLVNK 14 0 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2;A0A0B4J1Z0 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 DQT(0.079)AS(0.711)APAT(0.21)PLVNK 193.31 0.00011504 22321000.0 3683.2 4116.0 3770.5 4479.6 4091.9 3571.7 3741.8 3656.2 1737.4 2887.4 True False 3769.011393740383 3634.0968065235147 3258.4868098739735 3697.3219525063973 3721.7883674836207 3535.7719408441285 3459.5530134595383 3559.22569898864 2948.2409053246333 3258.025915657716 1.156838985112711 1.1154290667420548 1.0001414642572493 1.1348350345334801 1.1423446172104137 1.0852497900190405 1.0618555846450777 1.092448553549986 0.9049163455562801 1.0 11.669782364351843 -8.247357479206014 23.246132313779203 0.9524581959465647 1.0969095139590561 0.6007623468058523 0.04765117583831972 184.2542313045915 304166.3428382969 0.03292340137774832 0.012278548901141885 5.657733943639309e-09 8.247357479206014 0.14445131801249145 DQTASAPAT(ph)PLVNK ddPTM_A459_Selumetinib_30min_R1 1 DQTASAPATPLVNK 14 0 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2;A0A0B4J1Z0 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 DQT(0.005)AS(0.007)APAT(0.988)PLVNK 158.65 0.00071128 13571000.0 4031.4 4582.2 4467.4 5098.9 4245.7 4506.1 4379.4 3889.1 2275.2 3534.3 True False 4125.323776261127 4045.7138937930117 3860.751617671661 4208.47283320718 3861.6771846392185 4460.772725211448 4049.058332124833 3785.9484344228204 3860.848225966734 3987.9618319973247 1.0344441471735466 1.0144815984276265 0.9681014463817093 1.055294160400581 0.9683335366088852 1.1185595331982707 1.0153202319132801 0.9493441998482397 0.9681256713615718 1.0 11.961435886712216 -7.6603891753263005 6.451375419590681 0.9694582015098702 1.025495250346272 0.2476679175556229 0.04204773002861909 0.2878835679680861 15.73512269161581 0.019921698500138807 0.011333280832422644 2.1858020285383994e-08 7.6603891753263005 0.056037048836401815 DQTASAPAT(ph)PLVNK ddPTM_A459_Selumetinib_30min_R2 2 DQTASAPATPLVNK 14 0 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2;A0A0B4J1Z0 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 DQTAS(0.004)APAT(0.996)PLVNK;DQTAS(0.002)APAT(0.998)PLVNK 201.57 0.00013345 35354000.0 271939.0 248231.0 294562.0 286692.0 297964.0 185588.0 209010.0 228909.0 183252.0 251912.0 True False 256825.71903806913 267269.51951153355 275610.2016148563 247644.05502871482 260531.0984880423 211151.06239987374 218729.37914545808 229575.08729207504 219907.520488687 244638.64601401947 1.0498166304572796 1.092507352645408 1.126601238624669 1.0122850950316458 1.0649629677606705 0.8631140902724476 0.8940916846511789 0.9384252694029332 0.8989075277831811 1.0 17.900292801477626 -6.748404677290837 24.845280705499444 0.9135082993017614 1.0705508010965803 0.7506909656156289 0.04325644676962949 101.25203910537729 192994.8629064899 0.014223424852943273 0.014138192606494515 1.7848236940929078e-07 6.748404677290837 0.15704250179481893 DQTDFEHR ddPTM_A459_Selumetinib_30min_R2 2 DQTDFEHR 8 0 F8VZI0;A0A2R8Y891;P08237-2;P08237;P08237-3 F8VZI0 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 ; 172.23 0.00020644 4369500.0 33452.0 23231.0 37443.0 36546.0 32948.0 28635.0 27295.0 31168.0 29450.0 31724.0 False True 31592.871758966077 25012.74300056167 35033.958144855984 31568.371754633583 28808.77768114279 32579.211327350822 28564.271584016413 31258.69371985982 35340.822901751926 30808.04569114918 1.025474711238901 0.8118899605419491 1.1371691179658587 1.0246794642901622 0.935105652917778 1.057490359951994 0.9271692164564214 1.0146276084250325 1.147129657494145 1.0 14.911019547447253 -8.015179127613102 23.927710528126386 1.0760027963078018 0.988038100067806 0.12639071701957982 0.08841846740525618 755.2539512199135 1190539.2469805442 0.054100546215845674 0.02197520052311162 9.656525071173999e-09 8.015179127613102 -0.08796469623999581 DQTPAPKT(ph)PNR ddPTM_A459_Selumetinib_30min_R1 1 DQTPAPKTPNR 11 1 Q9BYW2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 DQT(0.008)PAPKT(0.992)PNR 139.74 0.011848 4021800.0 1149.4 1380.9 1709.9 1547.6 1352.8 1669.6 1295.9 1101.3 815.12 1057.2 True False 1176.178783656928 1219.2235860370067 1477.7049718083833 1277.3407120499385 1230.4394788562379 1652.8053398755087 1198.1492196649249 1072.0899464734396 1383.1991059906843 1192.9019180000478 0.9859811321527953 1.022065240771084 1.2387480894370766 1.0707843560109753 1.0314674327283533 1.3855333074210403 1.0043987704149846 0.898724304401191 1.1595245888360026 1.0 10.220259712245076 -10.750815951596307 3.864281558523599 0.9999071843231194 1.0895118578815637 0.03823615931311464 0.13320420191963905 48695561.461247936 6.667957147173456 40288.95035628332 0.03273961717245994 1.7749415188649103e-11 10.750815951596307 0.08960467355844426 DQVANSAFVER ddPTM_A459_Selumetinib_30min_R1 1 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 160.72 0.0083516 33203000.0 2769.5 2725.2 3281.8 3411.7 2965.0 2802.8 3040.2 2720.6 1425.3 2450.0 False True 2834.023961491091 2406.132317088891 2836.149585637028 2815.910640540689 2696.8162735132655 2774.606376738785 2810.8752663209384 2648.440850245744 2418.630000206744 2764.4813650209207 1.0251557479641915 0.8703738601872189 1.0259246531819413 1.018603589147138 0.9755234047283429 1.0036625357095823 1.0167821356609748 0.958024490147251 0.8748946658891443 1.0 11.432793131380802 -7.998252518019307 24.55941839828705 0.9304514166653074 0.98846330853164 0.14943077752332123 0.051698368803098915 70.63197941368219 992678.3588666739 0.027831095788189136 0.01321965193681062 1.0040318320128484e-08 7.998252518019307 0.0580118918663326 DQVANSAFVER ddPTM_A459_Selumetinib_30min_R2 2 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ; 188.27 5.0094e-12 0.0 95977.0 119993.0 126995.0 131140.0 149283.0 95593.0 109621.0 108709.0 90019.0 134883.0 False True 90642.98256637236 129196.07726169308 118824.27996170113 113278.50577088191 130528.73493304703 108760.06804314483 114718.59370989069 109025.32519225615 108025.31534101235 130988.57732187859 0.6919915035311446 0.9863156002085526 0.9071346707561676 0.8647968249362868 0.9964894466507443 0.8303019260670983 0.8757908212713263 0.8323269663762201 0.8246926377065799 1.0 16.99908148345456 -7.311527750995168 0.008292541201768176 1.771177595583745 4.275554758445238e-06 0.08503919515750191 0.08735271198818534 9977.30451803869 51.929479778583826 5476.352223838855 5609.70620696168 4.8805891376106804e-08 7.311527750995168 -1.7711733200289865 DQVDGVLS(ph)LER ddPTM_A459_Selumetinib_30min_R2 1 DQVDGVLSLER 11 0 H7C494 H7C494 DNAJB14 1 DQVDGVLS(1)LER 121.18 0.0045149 1064900.0 8693.1 6208.6 8075.4 6711.4 7102.8 7613.1 4731.4 8063.6 4521.7 7549.3 True False 8209.972303236522 6684.77965620452 7555.837555830728 5797.295742189235 6210.482764162347 8661.735420159059 4951.419475091239 8087.063740999154 5426.166346854049 7331.332093562995 1.1198472799295212 0.9118096917303532 1.030622738051227 0.7907561229260555 0.8471151879227011 1.1814681574395156 0.6753778729296208 1.10308244638102 0.7401337543579963 1.0 12.839859642662653 -2.494372430637587 1.394454429566562 0.916545997355159 136.88710935885803 0.12867301344341397 0.15358786809858507 2092.734967679888 7.9737734684249295 0.04031737184911878 907436.7596880005 0.0032035209564806283 2.494372430637587 135.97056336150285 DQVTAQEIFQDNHEDGPTAK ddPTM_A459_Selumetinib_30min_R2 1 DQVTAQEIFQDNHEDGPTAK 20 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 121.14 0.00034787 3332000.0 18265.0 15412.0 19617.0 20993.0 23275.0 15802.0 16723.0 19743.0 13351.0 19159.0 False True 17249.90442058818 16594.050842609293 18354.86357737466 18133.717185055066 20350.98641885996 17978.582063726146 17500.65263599586 19800.448861370405 16021.57305810832 18605.829888939817 0.9271236232704856 0.891873726765264 0.9865114153432982 0.9746255498033228 1.0937962208800773 0.9662875652976631 0.9406004860013835 1.0642067018542787 0.861104995248414 1.0 14.183467120991693 -5.2715935542858645 22.39269887544339 0.9893184199813815 0.9094986777757861 0.20064390961264045 0.060684050638420806 219.57317807221344 484223.5931098876 0.015280962011467097 0.03253956778749765 5.3506487944295955e-06 5.2715935542858645 -0.0798197422055954 DQYPQQSLEQIGTR ddPTM_A459_Selumetinib_30min_R2 1 DQYPQQSLEQIGTR 14 0 H0Y6S0;Q96AE7 H0Y6S0 TTC17 Tetratricopeptide repeat protein 17 0 82.20200000000001 0.042622 41872000.0 31075.0 28321.0 43636.0 49173.0 42035.0 20468.0 33378.0 42046.0 29349.0 51531.0 False True 29347.97590308117 30493.12963363207 40828.50726728454 42475.55257184364 36754.18750233205 23287.281209995344 34930.14313725225 42168.34689890999 35219.62007957616 50043.16613638279 0.5864532196683768 0.6093365385900855 0.8158657898665822 0.8487782818554064 0.7344496829430368 0.46534388225018475 0.6980002632538682 0.8426394681741054 0.7037848081712501 1.0 15.610885448524767 -9.16247872289081 0.76633404253949 1.0034550154403148 0.6899654509762165 0.3888249454299514 0.11436567890143909 2.6912135290879586 2.2604225465825465 0.14854205446867125 0.04359217744092093 6.878936130109694e-10 9.16247872289081 -0.31348956446409826 DRAPQTLPS(ph)PEADALAGSK ddPTM_A459_Selumetinib_30min_R2 1 DRAPQTLPSPEADALAGSK 19 1 P31274 P31274 HOXC9 Homeobox protein Hox-C9 1 DRAPQT(0.013)LPS(0.985)PEADALAGS(0.003)K 53.589 0.035651 2215200.0 11213.0 10459.0 9268.0 10107.0 11372.0 9809.1 9585.8 7212.0 7656.9 8548.8 True False 10589.826349195475 11261.171669014437 8671.706970235424 8730.409164452514 9943.347693030097 11160.21448685585 10031.558693902352 7232.9857259891305 9188.493951661272 8301.973931550117 1.2755793304711303 1.3564450770217955 1.0445355576557769 1.0516064295593857 1.197708855148562 1.3442844531760714 1.2083341596363326 0.8712368631394403 1.1067842452193326 1.0 13.019238686504545 -7.739437568389875 24.841617588492895 0.991757956343846 1.2088486078684622 0.44655022941013045 0.11146889436371225 207.8697234902356 234700.25493216034 0.05629570212495008 0.032467381504072156 1.822058982705869e-08 7.739437568389875 0.21709065152461615 DRAS(ph)PAAAEEVVPEWASCLK ddPTM_A459_Selumetinib_30min_R1 4 DRASPAAAEEVVPEWASCLK 20 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 DRAS(1)PAAAEEVVPEWASCLK;DRAS(1)PAAAEEVVPEWASCLK;DRAS(1)PAAAEEVVPEWASCLK;DRAS(1)PAAAEEVVPEWASCLK 169.91 1.1421e-09 336597000.0 26875.5 31480.8 34530.6 35654.1 33740.7 27034.399999999998 30368.800000000003 27019.300000000003 16915.3 25276.2 True False 27501.646859380347 27795.01330097313 29841.5341830087 29427.780745347445 30688.85964240441 26762.458481271242 28078.056965938846 26302.660392944526 28704.02865536882 28520.64648103746 0.9642715103833773 0.9745576180909229 1.0463133857379237 1.0318062307918971 1.0760225811434019 0.9383538517987247 0.9844817853132158 0.9222322646309015 1.0064298042631428 1.0 14.79971906344963 -6.783870735034385 24.99996815069813 0.9663254531363586 1.0184217697880549 0.27811172237474224 0.03863919441488504 313.61550948494573 349524.9257163592 0.01401994452724641 0.012373731363343927 1.6448612327522753e-07 6.783870735034385 0.05209631665169623 DRAS(ph)PAAAEEVVPEWASCLK ddPTM_A459_Selumetinib_30min_R2 4 DRASPAAAEEVVPEWASCLK 20 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 DRAS(1)PAAAEEVVPEWASCLK;DRAS(1)PAAAEEVVPEWASCLK;DRAS(1)PAAAEEVVPEWASCLK;DRAS(1)PAAAEEVVPEWASCLK 154.45 2.0139e-06 248531000.0 317807.0 307214.0 336944.0 365781.0 394195.0 302991.0 297464.0 306884.0 253926.0 339835.0 True False 300144.55922222126 330776.3259512958 315265.38987688924 315960.9967925801 344672.69995198696 344725.259971551 311296.6654137341 307776.98163261916 304718.29528523755 330023.08055263065 0.9094653583610662 1.0022824021804893 0.9552828527900856 0.9573906051161535 1.0443896813969047 1.0445489430445327 0.9432572561060312 0.9325922935972845 0.9233241953107653 1.0 18.332207399012205 -11.001983588450964 5.608564457893029 1.0000346296560196 0.9710983764100417 0.039111238320735486 0.04529450966394622 2.0993516274892717e-05 1.9498464560177986e-06 0.046942906404751225 0.011371703623883454 9.95443033425794e-12 11.001983588450964 -0.028936253245977928 DRCPLPCIPTLIGT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 DRCPLPCIPTLIGTPVK 17 1 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 DRCPLPCIPTLIGT(1)PVK;DRCPLPCIPTLIGT(1)PVK 166.28 2.0782e-06 89993000.0 15180.0 19708.7 14898.400000000001 14203.5 16459.1 14044.1 18580.3 17853.1 8958.400000000001 16357.7 True False 15533.6644648618 17401.196241673955 12875.27911105329 11723.125357716004 14970.377311090111 13902.829105022538 17178.773011914647 17379.57779295828 15201.75050435144 18457.370132490905 0.8415968446944431 0.9427776609974492 0.6975684519859446 0.635146029665382 0.8110785666446291 0.7532399797601225 0.9307270152032376 0.9416063972388263 0.8236141116112458 1.0 14.171909387186522 -7.264891599634176 24.848531345538927 0.9191207552130608 0.778672421436034 0.3941411984619815 0.08721693799944671 332.70942861166793 2394771.801328107 0.03817630728638185 0.02692089321422301 5.4338594427835194e-08 7.264891599634176 -0.1404483337770268 DRCPLPCIPTLIGT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 4 DRCPLPCIPTLIGTPVK 17 1 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 DRCPLPCIPTLIGT(1)PVK;DRCPLPCIPT(0.001)LIGT(0.999)PVK;DRCPLPCIPTLIGT(1)PVK;DRCPLPCIPTLIGT(1)PVK 161.02 3.1982e-05 35536500.0 281131.0 225916.0 250697.0 285979.0 263778.0 233236.0 282881.0 307702.0 253812.0 260473.0 True False 265506.8644765601 243243.03076556697 234567.42795825537 247028.1668587089 230639.84943476005 265362.14189439494 296035.5270180672 308597.36187719187 304581.49209981225 252952.46769987012 1.049631446140252 0.9616155674518919 0.9273182036578164 0.9765793910016706 0.9117912607534466 1.049059312634376 1.1703207709731278 1.2199816221731619 1.204105636404387 1.0 17.948506787988002 -7.077117921066308 3.3449690490134345 1.1664214815302838 0.9640335294436054 0.6223434814490821 0.0664404962657299 0.14738865468108206 3.1814885783690543 0.02594493230964295 0.020102190640209294 8.373019042917907e-08 7.077117921066308 -0.20238795208667837 DRDDRDFDFCR ddPTM_A459_Selumetinib_30min_R2 1 DRDDRDFDFCR 11 2 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 73.84100000000002 0.035883 16686000.0 40820.0 37381.0 32910.0 31078.0 29803.0 26670.0 31903.0 29589.0 21437.0 32548.0 False True 38551.38781540705 40248.00250114051 30792.606429698735 26845.122787459717 26058.88069779952 30343.550413844845 33386.55271459519 29675.099091277367 25724.998999825322 31608.254670140035 1.2196620223965138 1.2733383390245316 0.9741950876771492 0.8493073428954622 0.8244327619397807 0.9599881654493899 1.0562605579780746 0.9388401669425646 0.8138696447585713 1.0 14.948013754929454 -5.323359922003425 4.494203380941527 0.9210534612488368 1.2481791566125273 0.7505645249705359 0.07399441569174926 0.10024174353859198 4.099087386188786 0.021044271880971483 0.04772852132859494 4.7494145457184105e-06 5.323359922003425 0.3271256953636905 DRDGYSYGSR ddPTM_A459_Selumetinib_30min_R2 1 DRDGYSYGSR 10 1 Q13247-3;Q13247;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-2 Q13247-3 SRSF6 Serine/arginine-rich splicing factor 6 0 139.38 0.0043217 11394000.0 16240.0 15580.0 14821.0 17699.0 17191.0 11908.0 10044.0 13189.0 9742.5 16118.0 False True 15337.445813870898 16774.935902404137 13867.432995884694 15288.365667522025 15031.312890510064 13548.21890993867 10511.065901808422 13227.377806443517 11691.272228194168 15652.631460406696 0.9798637278764878 1.0717006878259614 0.8859489876167047 0.9767281435197602 0.9603058072715597 0.8655553504986601 0.6715206914822052 0.845057768075748 0.7469205582311972 1.0 13.934117597457725 -6.861243974466054 3.542511241171645 0.7992926107650734 0.9765265922509021 0.41304127346841735 0.08915511292547497 0.20714870872422497 5.052643601983772 0.031414096412011094 0.02774075660643654 1.37643600849395e-07 6.861243974466054 0.1772339814858287 DRDVQDETYR ddPTM_A459_Selumetinib_30min_R1 1 DRDVQDETYR 10 1 F5H1S9;Q9Y606-2;Q9Y606;F5GXL3;G8JLB3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 181.87 1.0293e-12 0.0 441.48 602.24 665.03 474.57 725.27 808.43 450.7 494.76 392.07 516.79 False True 451.7656250294591 531.72946082622 574.7225787483067 391.6952582822039 659.6694565568184 800.2979281957099 416.7033361393482 481.6373575930255 665.3141543401797 583.1250304608826 0.7747320067403016 0.9118618358844222 0.9855906516207426 0.6717174496396099 1.1312658899849277 1.3724293871645006 0.71460375454986 0.8259589838089361 1.1409459714228654 1.0 9.18766144110163 -6.277340268727874 24.673380307479245 1.0234301967597248 0.8520827160841472 0.20791333370047327 0.1849511473833447 1356.5121037923118 2104892.23740512 0.06101854413233866 0.06941720108281092 5.280313782912526e-07 6.277340268727874 -0.1713474806755776 DRDVQDETYR ddPTM_A459_Selumetinib_30min_R2 2 DRDVQDETYR 10 1 F5H1S9;Q9Y606-2;Q9Y606;F5GXL3;G8JLB3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 ; 136.02 0.0053572 6585900.0 32842.0 28066.0 32670.0 36332.0 37692.0 26862.0 29363.0 34658.0 25727.0 30455.0 False True 31016.773116942604 30218.571953586328 30568.047768406483 31383.51892380417 32956.79398924469 30561.996671042358 30728.437681680683 34758.849042059235 30873.118872440464 29575.685018407126 1.0487254343437382 1.021737009126892 1.033553331034657 1.0611256815952663 1.114320563284781 1.0333487340029952 1.038976363947483 1.1752508528687076 1.0438682604722713 1.0 14.852123963540171 -5.859514370501385 4.291747725557803 1.074304667271758 1.0333423606005343 0.08042347080374812 0.0464403171968034 0.44807208400409176 14.79946483503641 0.013136957143034792 0.020330662221979177 1.3819286780890068e-06 5.859514370501385 -0.04096230667122369 DRDWSHSGNPGASR ddPTM_A459_Selumetinib_30min_R2 1 DRDWSHSGNPGASR 14 1 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 0 91.307 0.013654 2805900.0 3993.9 4249.8 4212.8 4764.3 5219.4 4118.8 4146.1 5222.8 4463.2 4513.5 False True 3771.9350268484586 4575.745994739228 3941.7530345498285 4115.394121124084 4563.692309971974 4686.1273132562455 4338.9018653412895 5237.997483318918 5355.964712227479 4383.183527518655 0.8605469068697136 1.0439321023205212 0.8992899817684059 0.9389052717703181 1.0411821182754595 1.0691150128292914 0.9898973743856823 1.1950212557684479 1.2219348513703512 1.0 12.097763371623627 -6.869646312697368 0.9253723191677053 1.1360014363950968 0.9370400794452913 0.46423771518940715 0.08096812161874808 0.4988678665692213 0.9094529624148592 0.05161478767289913 0.04258971351135619 1.3500619188317731e-07 6.869646312697368 -0.19896135694980543 DRDYFDYSR ddPTM_A459_Selumetinib_30min_R1 1 DRDYFDYSR 9 1 Q9HCG8;B7WP74 Q9HCG8 CWC22 Pre-mRNA-splicing factor CWC22 homolog 0 112.3 0.02755 7170800.0 1696.6 2230.5 2850.9 2747.0 2362.2 2387.0 2581.5 2406.1 1018.9 1788.9 False True 1736.1274789910763 1969.3520230686827 2463.7634388727543 2267.2880175763626 2148.5394270802826 2362.9889472225927 2386.7753766224278 2342.282411885719 1728.9988824883549 2018.5227403616038 0.8600980530345977 0.9756402460523618 1.220577499380259 1.1232412557166407 1.0644118018186841 1.1706526262861325 1.1824367042775323 1.160394364180468 0.856566462153712 1.0 10.979084124748834 -5.017638959809303 4.856610696327692 1.1085549094168428 0.8800076890202678 0.35495495786899023 0.10132415611582052 0.16813108815985833 11.12457167979801 0.02543944630542595 0.08733744357501351 9.601985375900841e-06 5.017638959809303 -0.22854722039657493 DRDYFDYSR ddPTM_A459_Selumetinib_30min_R2 1 DRDYFDYSR 9 1 Q9HCG8;B7WP74 Q9HCG8 CWC22 Pre-mRNA-splicing factor CWC22 homolog 0 106.18 0.01304 0.0 20512.0 17427.0 19525.0 20227.0 23521.0 14540.0 16282.0 14845.0 18034.0 17695.0 False True 19372.025156041873 18763.594863363098 18268.782757212648 17472.047706478777 20566.081699592076 16542.75301902151 17039.14526217092 14888.196492277953 21641.303912060936 17184.099372868634 1.1273226915009393 1.091916105477618 1.0631213403046647 1.0167566729778563 1.1968088203716474 0.9626779187008356 0.9915646373107819 0.8663937614201882 1.2593795835602315 1.0 14.068786620881726 -6.792301707902128 24.999607334748795 1.0061253883583212 1.092198559623308 0.13681958940774763 0.10223205895613924 399.24857759494364 323403.29482978076 0.03469665938845979 0.030603008710345415 1.6132374383020512e-07 6.792301707902128 0.0860731712649867 DRDYSDHPS(ph)GGSYR ddPTM_A459_Selumetinib_30min_R1 2 DRDYSDHPSGGSYR 14 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DRDYSDHPS(0.649)GGS(0.35)Y(0.001)R;DRDYSDHPS(0.996)GGS(0.004)YR 97.129 0.006220799999999999 6801900.0 2825.8 3827.2 3252.7 3928.8 4837.9 3646.6000000000004 3808.0 3032.8 1056.52 1937.23 True False 2891.635641950363 3379.1096447829914 2811.00120580217 3242.7088327098704 4400.312799200617 3609.9185148478864 3520.75949416161 2952.360292077225 1792.8372748322665 2185.892340718154 1.3228627906717234 1.5458719452179501 1.2859742236338327 1.4834714282609678 2.0130510168469393 1.651462172954905 1.6106737868914889 1.3506430472725182 0.8201855331279705 1.0 11.094006631995395 -8.092441326913589 3.466822380769711 0.9148467664207149 1.5639493220748337 0.6355098771681549 0.1936231828492287 0.17043390268971506 3.6940200352331054 0.16255599693337375 0.055514878972161716 8.082741193875454e-09 8.092441326913589 0.6491025556541188 DRDYSDHPSGGSYR ddPTM_A459_Selumetinib_30min_R1 7 DRDYSDHPSGGSYR 14 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 ;;;;;; 166.45 0.00065579 90954100.0 16146.270000000002 18522.85 17332.399999999998 21259.569999999996 36170.3 19293.37 28400.7 16929.48 3767.85 8287.19 False True 16522.446675827687 16354.186110960663 14978.755280058258 17546.98519105422 32898.70275138512 19099.296214778347 26258.41233346524 16480.45519569887 6393.766257124104 9350.93156056642 1.7669305532621034 1.7489365637031815 1.601846316919353 1.8764959488155355 3.5182273058356475 2.0425019786607694 2.8081065681411825 1.7624399332787533 0.6837571439499244 1.0 13.190894381305485 -8.11427041895832 4.166706332603919 0.8622312396782679 2.193446176995044 0.4809405430859769 0.5533064517873713 0.213902423946134 6.0654397730276886 0.43856543383207186 0.1533285894036283 7.686516805473874e-09 8.11427041895832 1.3312149373167763 DRDYSDHPSGGSYR ddPTM_A459_Selumetinib_30min_R2 2 DRDYSDHPSGGSYR 14 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 ; 98.0 0.008523200000000002 50068000.0 55942.0 63211.0 139626.0 241206.0 280859.0 144512.0 99073.0 103438.0 155993.0 227691.0 False True 52832.96759356937 68059.08044460014 130642.6151732941 208353.32669644136 245574.98150868286 164417.21625067643 103680.09080942512 103738.98745491733 187195.95880859008 221116.96921773572 0.23893673914074096 0.3077967316817815 0.5908303448418255 0.9422765128951913 1.110611195411525 0.743575750121527 0.4688925104944364 0.4691588701759234 0.8465924595061569 1.0 17.7544502208341 -5.367261969290788 3.0527035573664763 0.7720266149475604 0.26062446710721354 0.5216501667109079 0.1977854189601495 0.2362652429880699 4.156800446184664 0.060729704798296535 0.1522776076525661 4.292774056937463e-06 5.367261969290788 -0.5114021478403469 DREEALHQFR ddPTM_A459_Selumetinib_30min_R1 1 DREEALHQFR 10 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;O15523;O15523-2;A0A087WVZ1;A0A2R8YDH3;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 95.775 0.017846 6580500.0 3136.3 3608.0 3938.4 3620.0 3556.8 3236.5 3385.4 3009.0 1967.4 2834.4 False True 3209.3696878225337 3185.5736826863044 3403.5869120826574 2987.8349558159566 3235.088068004044 3203.943748506878 3130.036552398824 2929.1915453905212 3338.534106789272 3198.222849394 1.0034853226161666 0.9960449389228482 1.0642119302998443 0.9342172501775766 1.0115267823244491 1.0017887743857379 0.9786799418908234 0.9158810012083882 1.0438716324667174 1.0 11.64305475272182 -5.75935615499192 24.999995455235716 0.9819071973921806 1.0187271363860304 0.16374072135159856 0.03859975569124436 100.75347260766164 1209066.3788939428 0.01034651475431276 0.016888459767063754 1.7403790428767842e-06 5.75935615499192 0.03681993899384983 DREEALHQFR ddPTM_A459_Selumetinib_30min_R2 4 DREEALHQFR 10 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;O15523;O15523-2;A0A087WVZ1;A0A2R8YDH3;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 ;;; 107.21 0.0091052 91848500.0 71144.3 63848.9 64307.5 72634.3 80892.9 58632.6 60297.5 64658.4 56704.8 66336.5 False True 67190.38461919806 68745.90532342832 60170.02546271199 62741.3830388437 70730.41071029856 66708.70843625047 63101.45322722953 64846.545239225634 68047.344464491 64421.19288207408 1.0429857258649822 1.0671318280192486 0.934009799738666 0.9739245771759404 1.0979369916321449 1.0355087425711564 0.9795138898272128 1.0066026774438992 1.0562881781629652 1.0 15.975247754786151 DREEDEEDAYER ddPTM_A459_Selumetinib_30min_R1 2 DREEDEEDAYER 12 1 P49756 P49756 RBM25 RNA-binding protein 25 0 ; 176.87 0.00029192 31909000.0 5750.5 6780.5 6363.0 6701.3 5999.0 5726.8 6751.8 5467.1 3345.33 4921.4 False True 5884.475461474825 5986.63590783107 5498.93954945713 5531.043753980521 5456.391509209472 5669.193591518368 6242.506290094635 5322.094748356436 5676.7806767639295 5553.109628495491 1.0596721215945293 1.0780691015194372 0.9902450910098388 0.9960263931398472 0.9825830704314363 1.0209043168222716 1.1241460564836576 0.9583990060355347 1.0222705936929153 1.0 12.439080162299922 -5.252685550277381 24.711419164820477 1.0130636579916081 1.068870617708173 0.22836379856858346 0.04189710413768375 833.7837406427253 2353693.4110973002 0.01102216489367983 0.028096630992344152 5.588746999648503e-06 5.252685550277381 0.05580695971656491 DREEDEEDAYER ddPTM_A459_Selumetinib_30min_R2 2 DREEDEEDAYER 12 1 P49756 P49756 RBM25 RNA-binding protein 25 0 ; 187.78 0.00033558 28567000.0 41471.4 38330.8 46250.1 41645.5 47379.3 41767.5 38840.2 41897.9 34355.9 40136.2 False True 39166.58561116782 41270.649107052195 43274.41891930142 35973.31105750543 41427.0887576839 47520.59399738526 40646.34626039625 42019.81595242927 41228.039984050905 38977.36361962868 1.0048546636808409 1.0588363417752717 1.1102448934619265 0.922928277257561 1.0628499444436914 1.2191844081895338 1.042819279853168 1.0780569040659393 1.0577431656585619 1.0 15.250348891348011 -6.5175993113757285 24.999633638471305 1.088684536863816 1.0278407469757556 0.11895911125163339 0.06881515596807847 475.98456537951523 2253937.612197236 0.022428121213538866 0.023036563586457236 3.0366916034887073e-07 6.5175993113757285 -0.060843789888060495 DREEDEEDAYERR ddPTM_A459_Selumetinib_30min_R2 2 DREEDEEDAYERR 13 2 P49756 P49756 RBM25 RNA-binding protein 25 0 ; 95.477 0.0094915 17168800.0 44732.0 44743.0 52827.0 55438.0 53977.0 36165.0 34816.0 35202.0 31931.0 45418.0 False True 42245.974516383816 48174.64422857951 49428.16833368871 47887.24876411581 47195.92669949753 41146.40047681659 36435.0129865952 35304.431991995174 38318.09222668389 44106.66432986422 0.9578138623323517 1.0922305044038638 1.1206507924522722 1.0857145851243115 1.070040716444331 0.932883978010478 0.826065936750637 0.8004330531087308 0.8687596944559477 1.0 15.428709036902474 -6.893750035482103 3.170859503633957 0.8584030698868625 1.071980587226309 0.6671078778662551 0.06395804376475743 0.13636111196962314 2.7323786776636405 0.023963920627283624 0.020762763310504435 1.27717369323533e-07 6.893750035482103 0.21357751733944652 DRELWVQR ddPTM_A459_Selumetinib_30min_R1 2 DRELWVQR 8 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 ; 104.44 0.032441000000000005 3269400.0 4570.2 5231.0 4928.1 5359.6 4629.3 4208.1 4646.0 4349.8 2277.8999999999996 3527.6 False True 4676.67676793883 4618.552088174075 4258.891088115619 4423.646472152268 4210.580632369298 4165.770334649096 4295.548479483941 4234.42917385832 3865.4299287665344 3980.401821733795 1.1749257932712307 1.1603230766692576 1.0699651137885668 1.1113567600130891 1.0578280336871217 1.0465703014964851 1.079174583839597 1.063819524636303 0.9711155058920206 1.0 11.958698362908649 -1.5228787452811443 0.2099607406127656 0.9945334772629897 1.9323332393062138 0.7789149770793953 0.02831062389030187 24.444014780175888 0.30424980336372087 0.04843388899181355 7.653879403892313 0.029999999999944273 1.5228787452811443 0.9377997620432241 DRELWVQR ddPTM_A459_Selumetinib_30min_R2 2 DRELWVQR 8 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 ; 124.08 0.01577 4996700.0 34342.0 32317.0 36429.0 38693.0 37610.0 28701.0 30151.0 30883.0 29182.0 34320.0 False True 32433.409121918394 34795.60998446692 34085.197800896225 33422.94665085199 32885.09556233399 32654.302228262502 31553.081243073077 30972.864417044133 35019.21541320625 33329.09242593115 0.9731260817856568 1.0440011248969616 1.0226860475317594 1.0028159850175764 0.9866783992218248 0.979753718191749 0.9467128849426372 0.9293041652987288 1.0507101413286648 1.0 15.024494411956042 -6.269290779926414 2.118073596011788 0.9751526906787165 1.0159047847194091 0.1307490282196747 0.03459067557092061 0.5186647343298045 4.568622691032612 0.011684845201641689 0.015007713499183417 5.379095070166356e-07 6.269290779926414 0.04075209404069269 DREPYFDR ddPTM_A459_Selumetinib_30min_R1 2 DREPYFDR 8 1 H0YIQ2;P49750-3;P49750-1;P49750;F8VU51;H0YI23 H0YIQ2 YLPM1 YLP motif-containing protein 1 0 ; 129.42 0.011496 15238300.0 7763.9 8069.1 9363.1 9317.7 6335.1 8726.1 7958.1 6810.200000000001 4388.9 5624.8 False True 7944.783764080407 7124.366020777182 8091.64244782682 7690.538609891257 5762.091323552745 8638.32335666488 7357.814109896936 6629.571373352781 7447.642747426775 6346.797870191708 1.251778286715854 1.122513457414075 1.2749173068564112 1.2117194792054975 0.9078737721607476 1.3610522240255234 1.1592954841769192 1.0445537275559291 1.1734488634662972 1.0 12.631813181747008 -14.522878745026091 0.10304119853180035 0.45777427547239885 1.273452772307619 0.18556289477494836 0.11695366089930295 324.26324898431704 2.249479935704997 37.268152658917046 1.7931282748756325 3.0000000017562732e-15 14.522878745026091 0.8156784968352202 DREPYFDR ddPTM_A459_Selumetinib_30min_R2 1 DREPYFDR 8 1 H0YIQ2;P49750-3;P49750-1;P49750;F8VU51;H0YI23 H0YIQ2 YLPM1 YLP motif-containing protein 1 0 121.09 0.019908 6672300.0 22742.0 18200.0 20073.0 19159.0 24190.0 12548.0 14652.0 20644.0 14148.0 21068.0 False True 21478.090683439154 19595.88147777635 18781.525033829927 16549.51114888154 21151.035938656194 14276.373100597106 15333.347032387206 20704.070622201823 16977.995328148932 20459.712098762164 1.049774824775692 0.9577789454311004 0.9179760176080988 0.8088828947833925 1.0337895194495847 0.6977797650173603 0.7494409969392918 1.0119433999002578 0.8298257202346518 1.0 14.32049822372309 -4.818304426132462 1.225970600585645 0.8689280745249484 1.1247102545645364 0.19875569109138835 0.10703573232301282 2.2325569541667303 3.0071954131616194 0.032606233517618835 0.7184168384846047 1.5194820494558262e-05 4.818304426132462 0.2557821800395881 DREREPEAASSR ddPTM_A459_Selumetinib_30min_R2 1 DREREPEAASSR 12 2 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 90.697 0.015256 950100.0 4274.9 5215.8 5898.5 5017.2 5515.2 2718.7 1890.8 2905.2 984.9 4471.3 False True 4037.3181717805837 5615.835088559659 5518.996931801217 4333.84870484725 4822.331269486424 3093.17624709861 1978.7259465491202 2913.653651018248 1181.9075204052785 4342.201951167421 0.9297859052122466 1.293315039630945 1.2710134152828636 0.9980762648964484 1.1105727747623342 0.7123520006403653 0.45569643439019014 0.6710083233772439 0.2721908224668172 1.0 12.084211110378469 -6.827193344477736 3.1194743590652156 0.5712784432542334 1.1387586378650043 0.6081453581660954 0.2007263598324144 0.1556056526438418 3.0648236396825133 0.07127679745177452 0.06385390619017212 1.488698173477645e-07 6.827193344477736 0.5674801946107709 DRFS(ph)AEDEALSNIAR ddPTM_A459_Selumetinib_30min_R1 2 DRFSAEDEALSNIAR 15 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5;C9JJC9;C9JC17;C9J321;C9J0U5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 DRFS(1)AEDEALSNIAR;DRFS(1)AEDEALSNIAR 159.5 7.536600000000001e-05 7996100.0 2229.3999999999996 2551.3 2501.6 2462.0 2258.6 1991.67 2389.0 2140.4700000000003 1199.84 1806.87 True False 2281.3406823427463 2252.5926099328094 2161.896460305194 2032.0579174637812 2054.310028788216 1971.6356080916726 2208.795806605067 2083.6977823735606 2036.0408471536239 2038.7993649042253 1.1189628178297548 1.1048623266755957 1.0603772482569669 0.9966934228269387 1.0076077441218545 0.9670572014251595 1.0833806624757445 1.0220219891384184 0.9986469891063896 1.0 10.993504093611664 -5.447068061327824 2.565975224725687 1.0128431997543688 1.1142284833003995 0.6710103064554461 0.02836442050769788 0.1761817998729687 2.2440964911126957 0.008243866190348066 0.0205297034085931 3.572168518120805e-06 5.447068061327824 0.10138528354603071 DRFS(ph)AEDEALSNIAR ddPTM_A459_Selumetinib_30min_R2 3 DRFSAEDEALSNIAR 15 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5;C9JJC9;C9JC17;C9J321;C9J0U5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 DRFS(1)AEDEALSNIAR;DRFS(1)AEDEALSNIAR;DRFS(1)AEDEALSNIAR 127.49 0.001654 6353000.0 16713.7 20965.4 23202.600000000002 27126.800000000003 31031.100000000002 17806.4 17423.7 19967.4 18107.5 23209.4 True False 15784.819464242237 22573.37876561384 21709.769977080767 23432.083043659874 27132.695796446205 20259.069969594555 18233.93657440656 20025.501828218974 21729.5059658225 22539.284316736765 0.7003247859347985 1.0015126677669957 0.9631969530177126 1.0396107841924755 1.2037958000422648 0.8988337732867137 0.8089847183331715 0.8884710599860903 0.9640725792560789 1.0 14.460154086315702 -10.328867965427513 15.618019053029453 1.0000061512497802 0.9473769153594588 0.01661718922869182 0.1279573838367644 0.0 0.0 0.13018763797580293 0.031575140148465214 4.689559328508381e-11 10.328867965427513 -0.052629235890321424 DRHDDYYR ddPTM_A459_Selumetinib_30min_R2 2 DRHDDYYR 8 1 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 0 ; 107.69 0.037178 5498800.0 9492.8 4881.9 4310.6 4561.200000000001 7056.0 4796.0 7032.5 6839.9 6417.5 5804.1 False True 8965.228178689262 5256.326032217379 4033.2606890264187 3939.956691491126 6169.562198559657 5456.605466246712 7359.525184634382 6859.802976593602 7701.179319931853 5636.520552137148 1.5905607184009998 0.9325480114189215 0.7155585882672182 0.6990051140676226 1.094569272211808 0.9680804701719363 1.3056858600194294 1.2170279364975671 1.3663002287842039 1.0 12.460589140331477 -7.253166116370088 23.59977778218614 1.2403391651806246 0.9746657717977616 0.15514478919256136 0.24841271381253135 484.09782605497685 1380909.3140578435 0.09925922211899967 0.07540700350581085 5.5825662236749895e-08 7.253166116370088 -0.265673393382863 DRICS(ph)DEEEDEEK ddPTM_A459_Selumetinib_30min_R2 2 DRICSDEEEDEEK 13 1 Q9NPG3;Q9NPG3-2 Q9NPG3 UBN1 Ubinuclein-1 1 DRICS(1)DEEEDEEK;DRICS(1)DEEEDEEK 140.49 0.00048349 12709600.0 74915.0 58868.0 63558.0 64045.0 65312.0 56502.0 72880.0 66914.0 55821.0 56820.0 True False 70751.524208506 63382.98630954604 59468.747476718105 55321.960516212675 57106.92266331179 64284.63762591156 76269.06440898031 67108.70866179091 66986.75976905586 55179.45896391042 1.2822076464138645 1.1486699489206853 1.0777334282239528 1.0025825108650568 1.034930819105385 1.165010292470542 1.3822002941142162 1.2161900446628644 1.2139800031904606 1.0 15.751843690646036 -7.000541758119924 24.99399850547043 1.2286079753887085 1.1033649894359359 0.1189776536045487 0.11214051241709926 31.86289840117289 1470058.4469117916 0.040279039342080034 0.035122359432265514 9.987533335641064e-08 7.000541758119924 -0.1252429859527726 DRLGS(ph)YSGPTSVSR ddPTM_A459_Selumetinib_30min_R1 1 DRLGSYSGPTSVSR 14 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 DRLGS(0.972)YS(0.028)GPTSVSR 140.77 0.0026571 24202000.0 3654.4 4188.5 5234.4 5383.5 4276.9 3641.2 3988.7 3749.1 2375.9 3523.8 True False 3739.5404097754263 3698.1084728191795 4523.597230501085 4443.372785810831 3890.055150148025 3604.57283394508 3687.8291476792074 3649.661689206914 4031.728771129732 3976.114054718664 0.9405012930495584 0.9300810846787554 1.1376930259665698 1.1175164305303684 0.9783560271696662 0.9065566994154365 0.9274958154941924 0.9178966294680778 1.0139872034971098 1.0 11.95714342582209 -6.5128301429971405 23.293500091745344 0.9460063280005366 1.0338138877126268 0.22023982705525436 0.06891335810833231 299.26972966681257 693735.8959081594 0.023993432514184426 0.02544242976513149 3.070222548963645e-07 6.5128301429971405 0.0878075597120902 DRNGIGPGSHSEFAAS(ph)IGSPK ddPTM_A459_Selumetinib_30min_R1 1 DRNGIGPGSHSEFAASIGSPK 21 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 DRNGIGPGSHSEFAAS(0.841)IGS(0.159)PK 98.766 0.00017608 9636800.0 2670.5 3504.1 4034.5 3664.2 3253.7 3110.0 3292.8 3302.6 1747.9 2974.6 True False 2732.717454111558 3093.8383429881073 3486.6370599221746 3024.3162555527147 2959.4034094873923 3078.716223654069 3044.42144495151 3215.004319643314 2966.058638434976 3356.4188850576447 0.814176521970268 0.9217676484784086 1.0387967590827965 0.9010544747607608 0.8817145627032086 0.9172622157979526 0.9070445463481605 0.957867426487233 0.883697398927022 1.0 11.71270706172816 -11.895027856569818 2.1502029331014327 1.5207328986553719 0.9175191847691314 0.18046055875183087 0.05462668136010663 11746176.442878123 838475.6160469798 29923536.879670072 0.014465175247153622 1.2734213984458297e-12 11.895027856569818 -0.6032137138862405 DRNGIGPGSHSEFAASIGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 DRNGIGPGSHSEFAASIGSPK 21 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 DRNGIGPGSHSEFAAS(0.062)IGS(0.938)PK;DRNGIGPGSHSEFAAS(0.056)IGS(0.944)PK;DRNGIGPGSHSEFAAS(0.371)IGS(0.628)PK 88.829 0.00046966 24881500.0 88048.2 77533.7 79967.9 82343.2 83074.9 54638.6 74243.5 73246.9 50197.9 75108.8 True False 83154.8335288711 83480.2854798608 74822.85237646611 71127.91411005717 72638.28836297104 62164.57119017255 77695.96986070434 73460.03635232296 60238.882646514525 72940.21378790129 1.1400409898807304 1.1445028900327656 1.025810708397966 0.9751536281054235 0.9958606451880139 0.8522674662146917 1.0652007421671679 1.0071266937321193 0.8258665490298638 1.0 16.1544268077715 -5.4223539558194425 1.9209285032254038 0.9600139648822222 1.1529713711550726 0.5293911032583547 0.06796037322124103 0.2881138765893727 2.0042986375520337 0.019646255808631205 0.06091867487351436 3.7813427459741045e-06 5.4223539558194425 0.1929574062728504 DRPFFAGLVK ddPTM_A459_Selumetinib_30min_R1 2 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 ; 122.94 0.012142 29391000.0 7446.7 7950.0 7189.9 7343.7 7776.0 6066.6 7832.700000000001 8020.6 4683.3 6772.9 False True 7620.193621244165 7019.21030414527 6213.551071293702 6061.2606533220005 7072.662172964302 6005.575512032083 7241.873132857054 7807.867633419477 7947.218045301514 7642.267688632733 0.9971115814980676 0.9184721852370846 0.8130506970510686 0.7931233110739689 0.9254664271292572 0.7858368427691823 0.9476078865477018 1.0216689537103052 1.0399031241894825 1.0 12.89978507707345 -7.550431959996587 4.118710984378004 1.0206899017364006 0.8697750556508326 0.5323007642496529 0.06238411162504025 0.1721310127457627 6.631289820583511 0.0318272424280309 0.01826640432099363 2.815581091751254e-08 7.550431959996587 -0.15091484608556804 DRPFFPGLVK ddPTM_A459_Selumetinib_30min_R1 1 DRPFFPGLVK 10 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 121.5 0.013404 23798000.0 5289.0 5475.3 5634.1 5618.1 4441.1 3524.1 4156.8 3695.3 2134.8 3842.2 False True 5412.223409397502 4834.24933060209 4869.020165896025 4637.004299798241 4039.403289139886 3488.650753626787 3843.2492293411206 3597.28863997394 3622.5996803770163 4335.3837961973 1.2483839179693228 1.1150683671517987 1.1230886110168132 1.069571811350474 0.93172911073824 0.8046924834398261 0.8864841984029542 0.8297509076657142 0.8355891544260766 1.0 12.081944000453198 -6.142770926657324 1.5690555894409874 0.8592961406520457 1.169376953141059 0.823905895610093 0.05996700675296177 0.14426858809061016 0.7089261033892081 0.02047135468112763 0.03078674590497181 7.198285592816101e-07 6.142770926657324 0.3100808124890132 DRPGDEDWVHR ddPTM_A459_Selumetinib_30min_R1 2 DRPGDEDWVHR 11 1 O60826 O60826 CCDC22 Coiled-coil domain-containing protein 22 0 ; 96.745 0.015871 11826200.0 8489.7 10204.6 11027.2 10883.7 10675.5 9084.2 9509.0 9532.8 4945.9 7835.9 False True 8687.493491919447 9009.84068801017 9529.766808073813 8983.066107351971 9709.902909912602 8992.821195793666 8791.72847426018 9279.959177101613 8392.831065756356 8841.714093129565 0.9825576127450271 1.0190151584986498 1.0778189282866426 1.0159869469577447 1.0981923649236363 1.0170902498172292 0.9943466144298619 1.0495656248727365 0.9492312211585746 1.0 13.11011036852509 -8.256216901306617 24.99889794210599 0.9746156089884817 1.0328723594024154 0.2932763559458952 0.035491293373894006 487.5453601022147 2333803.9960564645 0.02558019536510005 0.009027756669223322 5.5434878333725625e-09 8.256216901306617 0.058256750413933744 DRPGS(ph)PESPLLDAPFSR ddPTM_A459_Selumetinib_30min_R1 3 DRPGSPESPLLDAPFSR 17 1 A0A2R8Y5P9;Q8TF72 A0A2R8Y5P9 SHROOM3 Protein Shroom3 1 DRPGS(0.996)PES(0.004)PLLDAPFSR;DRPGS(0.958)PES(0.042)PLLDAPFSR;DRPGS(0.998)PES(0.002)PLLDAPFSR 103.92 0.0096849 25280000.0 2997.79 3271.27 3879.8 3650.8 3408.7999999999997 2990.33 3063.68 3222.5999999999995 1775.73 2826.94 True False 3067.632674316077 2888.2681876278366 3352.9444702159008 3013.256314003562 3100.47464187252 2960.2499952024036 2832.584151017081 3137.1261795199375 3013.2841158121964 3189.8052857274456 0.9616990378823369 0.9054684938140848 1.0511439319567277 0.9446521163803197 0.9719949539695638 0.928034701192524 0.8880116174147917 0.9834851655543939 0.9446608322128375 1.0 11.639252645364119 -6.7432955718635945 24.875249202967776 0.9440046050000231 0.9670077895186986 0.034982316911401634 0.04416298139307315 758.4374413200017 1039819.8928841412 0.014515013577418443 0.014485961952678886 1.8059446190241507e-07 6.7432955718635945 0.023003184518675446 DRPGS(ph)PESPLLDAPFSR ddPTM_A459_Selumetinib_30min_R2 2 DRPGSPESPLLDAPFSR 17 1 A0A2R8Y5P9;Q8TF72 A0A2R8Y5P9 SHROOM3 Protein Shroom3 1 DRPGS(1)PESPLLDAPFSR;DRPGS(0.998)PES(0.002)PLLDAPFSR 144.95 0.00027085 21937000.0 23897.0 22537.5 22505.4 26820.0 26147.0 19548.8 21271.3 20169.6 16455.7 23259.7 True False 22568.90040727049 24266.053780515613 21057.427066026805 23167.069732919397 22862.1801028542 22241.469753662157 22260.45759828133 20228.29019674298 19747.29981067433 22588.132025041687 0.9991485963624669 1.0742833339921045 0.9322341060642859 1.0256301719520626 1.0121323922451266 0.9846529021968168 0.9854935137444261 0.895527358097494 0.8742334155290951 1.0 14.463277348393024 -7.64979328900819 4.465228652720139 0.9140045282953981 1.0043577351315596 0.388315736046526 0.0451987940821385 0.1955717208854804 6.68993493906495 0.021895334773715986 0.012037842245379703 2.2397869555094427e-08 7.64979328900819 0.09035320683616144 DRPPCSPSR ddPTM_A459_Selumetinib_30min_R2 1 DRPPCSPSR 9 1 O95758-1;O95758-6;O95758-2;O95758;O95758-5;O95758-4;B1ALY4;X6R242 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 95.775 0.030122000000000006 0.0 2836.4 2855.8 2353.2 2351.6 2154.2 2818.5 2355.5 2999.4 1027.7 2278.7 False True 2678.7642430088304 3074.830677155695 2201.7976739704363 2031.3080232637315 1883.5701372076537 3206.722791204414 2465.0354173347014 3008.1277574225996 1233.2687163371968 2212.908010226376 1.210517667535036 1.3894977391496477 0.9949793049667695 0.9179360433766665 0.851174169239402 1.4490990029343211 1.113934879327647 1.359355085489918 0.5573068155738818 1.0 11.111727764744256 -5.266188996591835 24.84551360894628 1.0508162497364886 1.3000077066345708 0.16283240271058197 0.24095476928219564 643.1135251821104 3364181.6057881927 0.06260147630281755 0.13747353924275438 5.417650733710114e-06 5.266188996591835 0.2491914568980822 DRPVGGS(ph)PGGPR ddPTM_A459_Selumetinib_30min_R2 1 DRPVGGSPGGPR 12 1 Q8NHG8 Q8NHG8 ZNRF2 E3 ubiquitin-protein ligase ZNRF2 1 DRPVGGS(1)PGGPR 104.9 0.045318 26485000.0 48793.0 43662.0 53799.0 54390.0 52084.0 33249.0 42440.0 39781.0 43037.0 44288.0 True False 46081.28039385486 47010.73500454233 50337.63091192229 46981.98817201663 45540.742283132226 37828.74794562907 44413.54409326461 39896.75612390095 51645.60255425117 43009.29036595684 1.071426196567279 1.0930367510028194 1.1703897107720256 1.0923683644221274 1.058858258195748 0.8795482934908331 1.0326500092272919 0.9276311184032101 1.20080108541224 1.0 15.392360707205858 -6.5263872545987835 24.99539526110828 1.0011432878710247 1.1060197724981005 0.24309416764462743 0.08169560739338597 140.97193407290203 1004303.020379548 0.026166119105291343 0.02629111387138547 2.975861709808499e-07 6.5263872545987835 0.10487648462707577 DRPVS(ph)QPSLVGSK ddPTM_A459_Selumetinib_30min_R2 3 DRPVSQPSLVGSK 13 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 DRPVS(1)QPSLVGSK;DRPVS(1)QPSLVGSK;DRPVS(0.999)QPS(0.001)LVGSK 102.84 0.004935800000000001 117742000.0 598737.0 570005.0 636801.0 777139.0 804256.0 429217.0 602297.0 620285.0 534383.0 505703.0 True False 565461.5944741147 613722.5506450501 595829.9169565048 671291.3275604503 703218.171140135 488337.7457060086 630305.0039288643 622089.9266562907 641274.531908553 491102.04041581176 1.1514136532508465 1.2496843835660236 1.2132507461219686 1.366908040113362 1.4319186508464237 0.9943712416518109 1.2834501835813807 1.2667223417145093 1.3057867390768556 1.0 18.905663291047937 -6.7394605704430335 24.999339336777147 1.1938225324725533 1.2816315345849028 0.15630090218569714 0.12479708910884006 593.4331748620815 674987.0054626401 0.04195169284931464 0.04191893364928561 1.821962481392935e-07 6.7394605704430335 0.08780900211234943 DRRPVHLDQAAFR ddPTM_A459_Selumetinib_30min_R1 1 DRRPVHLDQAAFR 13 2 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 0 103.46 0.0053714 10687000.0 2527.6 3017.3 3892.9 3440.2 2826.8 2584.0 2338.4 2475.2 1618.2 1867.9 False True 2586.4881621465556 2664.033113295287 3364.26556216905 2839.43365055195 2571.116439112077 2558.00730608428 2162.0126053433582 2409.549655417287 2745.9672113481774 2107.663159886766 1.2271828873668382 1.26397479635143 1.5962064651496755 1.347195180231977 1.2198896332420641 1.2136698855720895 1.025786589855047 1.1432327998496399 1.30284917609686 1.0 11.041428603064647 -6.504169364190586 2.1618313119997468 1.1363127451831834 1.3680375575991097 0.42864862063498177 0.12109431915992741 0.32354907512573033 3.028824769793865 0.0455803279842481 0.049757548713778854 3.132064057997696e-07 6.504169364190586 0.23172481241592635 DRS(ph)ATVS(ph)S(ph)S(ph)VPMPAGGK ddPTM_A459_Selumetinib_30min_R2 2 DRSATVSSSVPMPAGGK 17 1 A0A0U1RRL8;Q8TB22-4;Q8TB22;Q8TB22-2 A0A0U1RRL8 SPATA20 Spermatogenesis-associated protein 20 4 DRS(0.959)AT(0.041)VS(1)S(1)S(1)VPMPAGGK;DRS(0.958)AT(0.042)VS(1)S(1)S(1)VPMPAGGK 71.781 0.032523 23323000.0 0.0 0.0 910.17 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 851.6106531181682 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DRS(ph)FSEGGER ddPTM_A459_Selumetinib_30min_R1 1 DRSFSEGGER 10 1 G3V2D5;G3V515;G3V2P5;Q07352 G3V2D5 ZFP36L1 Zinc finger protein 36, C3H1 type-like 1 1 DRS(0.963)FS(0.037)EGGER 133.98 0.010348 4759300.0 2164.5 2058.7 2524.1 2982.5 2572.0 2161.4 2493.2 2130.0 2049.8 1579.4 True False 2214.928638616164 1817.666446936334 2181.3410838888485 2461.6623634588664 2339.363054123481 2139.658278394183 2305.1359167131627 2073.5054807849147 3478.360888531389 1782.131374658794 1.2428537368858303 1.0199396479871432 1.2240068913586615 1.3813024103961893 1.3126771052843254 1.2006175912838306 1.293471373374201 1.1634975458427732 1.951798244502235 1.0 10.799387977628868 -5.533855724692578 5.872549376883967 1.3272239793814884 1.1282135413071952 0.1010779395610214 0.23858528148249877 0.3366340734792679 42.60415611940393 0.061869507104920604 0.11456922372338349 2.9251239606855565e-06 5.533855724692578 -0.1990104380742932 DRS(ph)FSEHDLAQLR ddPTM_A459_Selumetinib_30min_R2 1 DRSFSEHDLAQLR 13 1 Q8WWL2-4;Q8WWL2-3;Q8WWL2-2;Q8WWL2 Q8WWL2-4 SPIRE2 Protein spire homolog 2 1 DRS(0.987)FS(0.013)EHDLAQLR 65.477 0.041684 2377900.0 5773.1 6493.6 8794.6 6845.4 7562.9 6376.5 4417.4 7341.4 4818.4 7205.7 True False 5452.254213550373 6991.6382397850775 8228.765010836481 5913.0447110263385 6612.78088881616 7254.8049948962025 4622.817852912043 7362.7622585658 5782.214637344705 6997.652718343005 0.779154729879397 0.9991405005649735 1.1759321792672492 0.8450040247819709 0.9449998670957223 1.0367483621870976 0.6606240748121456 1.0521760017135076 0.8263077449081944 1.0 12.772655352504131 DRS(ph)FSENGDR ddPTM_A459_Selumetinib_30min_R1 1 DRSFSENGDR 10 1 P47974 P47974 ZFP36L2 Zinc finger protein 36, C3H1 type-like 2 1 DRS(0.927)FS(0.073)ENGDR 196.02 0.00080808 7756100.0 2575.3 2819.0 2938.9 3387.9 3110.2 2602.7 2860.2 3117.2 1827.1 2383.2 True False 2635.299479338513 2488.9501694824535 2539.8135222221536 2796.2668637593615 2828.88295915041 2576.5192010625237 2644.4528112397675 3034.521729907388 3100.4552538958433 2689.1069343338204 0.9799905856073227 0.9255675695541083 0.9444821586655676 1.039849634857339 1.0519786041350627 0.9581319240846076 0.9833944412831187 1.1284496317953745 1.1529683756008489 1.0 11.392911410853037 -7.754806785701401 24.79991306424394 1.1055317605178636 0.9834690071953475 0.48001639711452504 0.05226029283790648 110.267384018709 412305.3957010834 0.026143468702422987 0.014641860145274717 1.7587058747485462e-08 7.754806785701401 -0.12206275332251615 DRS(ph)SPPPGYIPDELHQVAR ddPTM_A459_Selumetinib_30min_R1 3 DRSSPPPGYIPDELHQVAR 19 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 DRS(0.5)S(0.5)PPPGYIPDELHQVAR;DRS(0.5)S(0.5)PPPGYIPDELHQVAR;DRS(0.5)S(0.5)PPPGY(0.001)IPDELHQVAR 158.98 9.7666e-07 134178000.0 10417.9 12533.0 13070.4 13100.7 11557.599999999999 10409.199999999999 10697.2 10854.1 6479.8 9594.2 True False 10660.616800295371 11065.630533566375 11295.511470568035 10812.908675596167 10512.217120660007 10304.492898797404 9890.301591634876 10566.214008914336 10995.747334132939 10825.709025421926 0.984749984990464 1.0221621981138642 1.0433969215358436 0.9988175970926524 0.9710419055208533 0.951853857756517 0.9135938873296483 0.9760297440197017 1.0157068981174087 1.0 13.40217389632241 -6.152686924686594 3.342096179425519 0.9660848686165487 1.0176614713117333 0.3220211523753719 0.029167363114340147 0.2798185553416899 5.869574103166525 0.009502158673226044 0.012652260707387787 7.035793351776497e-07 6.152686924686594 0.051576602695184603 DRS(ph)SPPPGYIPDELHQVAR ddPTM_A459_Selumetinib_30min_R2 7 DRSSPPPGYIPDELHQVAR 19 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 DRS(0.5)S(0.5)PPPGYIPDELHQVAR;DRS(0.5)S(0.5)PPPGYIPDELHQVAR;DRS(0.5)S(0.5)PPPGY(0.001)IPDELHQVAR;DRS(0.656)S(0.344)PPPGYIPDELHQVAR;DRS(0.499)S(0.499)PPPGY(0.001)IPDELHQVAR;DRS(0.496)S(0.496)PPPGY(0.007)IPDELHQVAR;DRS(0.473)S(0.473)PPPGY(0.053)IPDELHQVAR 148.52 5.701300000000001e-05 244694700.0 322812.0 277367.0 314887.0 354560.0 351611.0 272504.0 277139.0 244696.0 251258.0 304079.0 True False 304871.40135882335 298640.1570245265 294627.5132430434 306268.3163498849 307438.48273777746 310038.95245498186 290026.51264051005 245408.0248483966 301516.6207350891 295299.44917787565 1.0324143922638405 1.0113129498072262 0.9977245608256197 1.0371448954698255 1.0411075387837576 1.0499137513400094 0.9821437643990002 0.8310480277955865 1.0210537865022176 1.0 18.171819139851827 -7.523331426787977 24.998784091368154 0.9369497252073945 1.0261750777921153 0.32760181942576216 0.04923421931380229 15.426160126053444 851709.4321460018 0.021565132250543767 0.012604641973242691 2.9968746160616135e-08 7.523331426787977 0.08922535258472075 DRS(ph)SSAPNVHINTIEPVNIDDLIR ddPTM_A459_Selumetinib_30min_R1 3 DRSSSAPNVHINTIEPVNIDDLIR 24 1 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056;A0A2R8Y679;A0A2R8Y492;A0A2R8YDP5 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 DRS(0.333)S(0.333)S(0.333)APNVHINTIEPVNIDDLIR;DRS(0.333)S(0.333)S(0.333)APNVHINTIEPVNIDDLIR;DRS(0.333)S(0.333)S(0.333)APNVHINTIEPVNIDDLIR 83.064 6.8396e-05 12564100.0 1351.13 1490.82 2249.44 2080.05 1745.82 1566.27 1566.65 1711.26 897.83 1400.88 True False 1382.6087001586784 1316.2741013365842 1943.9784032894615 1716.8083148743042 1587.9108892495542 1550.514745859375 1448.4763291828497 1665.8718258441281 1523.5519350912953 1580.696593726739 0.874683165413144 0.8327177439114122 1.229823870693761 1.0861086951713237 1.0045639976396776 0.9809059828513924 0.9163531666553673 1.0538846179940045 0.9638484331134565 1.0 10.62634476131954 DRS(ph)SSAPNVHINTIEPVNIDDLIR ddPTM_A459_Selumetinib_30min_R2 1 DRSSSAPNVHINTIEPVNIDDLIR 24 1 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056;A0A2R8Y679;A0A2R8Y492;A0A2R8YDP5 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 DRS(0.333)S(0.333)S(0.333)APNVHINTIEPVNIDDLIR 79.416 0.00012199 1724300.0 3641.2 4471.0 5745.1 6349.9 4558.6 3465.4 2572.8 3715.4 3498.2 6730.8 True False 3438.8366808784945 4813.91132346912 5375.466520791923 5485.03266581152 3985.907913598927 3942.7273942308925 2692.440297906484 3726.211198882421 4197.937747874655 6536.464315281392 0.5261004290712561 0.7364702217091326 0.8223813764613984 0.8391436717535865 0.6097957123823654 0.6031896150665605 0.41191080805136704 0.5700652553355229 0.6422337131192515 1.0 12.674294753084713 -10.51325200274513 4.406424743198998 1.0000115165077743 0.6434361490782289 0.4298052239253657 0.12429240468248384 198313579.3666856 373748024.75721574 36498.36649554455 0.03513545043245093 3.067241681122005e-11 10.51325200274513 -0.35657536742954543 DRS(ph)VSVDSGEQR ddPTM_A459_Selumetinib_30min_R1 1 DRSVSVDSGEQR 12 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 DRS(0.971)VS(0.029)VDSGEQR 143.05 0.0040705 1901100.0 500.88 567.25 834.57 741.15 707.83 594.02 600.88 756.68 385.15 597.11 True False 512.5495294571793 500.83610629262915 721.2399779648653 611.7220656085628 643.8069014775367 588.0446981270065 555.5551378287363 736.6103883569622 653.5714197569831 673.7548848439357 0.7607359011221166 0.7433506124540228 1.0704782914218556 0.9079296927847259 0.9555506252495135 0.8727872871203264 0.8245656548485308 1.093291351093634 0.9700433116835543 1.0 9.39608001747597 -5.240739005765071 24.568640825174832 0.9549308294286537 0.7520431813790045 0.5350614230546928 0.07801136607818471 526.5489639481176 624941.9442268403 0.020391959896986493 0.05381615847428518 5.744615877533284e-06 5.240739005765071 -0.2028876480496492 DRS(ph)VSVDSGEQR ddPTM_A459_Selumetinib_30min_R2 1 DRSVSVDSGEQR 12 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 DRS(0.989)VS(0.011)VDSGEQR 139.64 0.0054188000000000005 2284900.0 5590.6 8315.8 8300.9 6241.2 7241.6 4853.4 6022.6 6129.0 6214.9 7563.1 True False 5279.896832944994 8953.5951204886 7766.829131336558 5391.137793329474 6331.845467274605 5521.911795221395 6302.662833555503 6146.834375289432 7458.053658814876 7344.733651706285 0.718868386972535 1.219049668112683 1.057469133619599 0.7340140635429356 0.86209327220513 0.7518192023122005 0.8581199989588875 0.8369036464462446 1.0154287428901203 1.0 12.842494458720733 -5.742622192465165 24.999962561946933 0.8535030213179918 1.0205211781833003 0.14499869993808434 0.14298333320533738 366.73090617449327 487224.0959586744 0.037335742120059766 0.06453075024717447 1.8087469322425838e-06 5.742622192465165 0.16701815686530852 DRSEEERTTEAEKNER ddPTM_A459_Selumetinib_30min_R1 1 DRSEEERTTEAEKNER 16 3 P26038 P26038 MSN Moesin 0 94.402 0.009735 0.0 299.71 0.0 140.69 145.0 164.56 0.0 160.32 212.69 71.835 121.85 False True 306.69265986585833 0.0 121.58507075485201 119.67847198710326 149.67557705542774 0.0 148.2269333256275 207.04877028551337 121.89874837918444 137.49063441950995 2.2306440083044565 0.0 0.8843152936793713 0.8704481762877142 1.0886238010855287 0.0 1.078087492660475 1.5059118110821164 0.8865967408896251 1.0 7.1031895383268475 -10.764952358031309 7.781588445945652 1.0000001093477286 0.9135667219636197 0.0 0.6177319721056079 1.1212169049671882e-06 1.0957806213231788e-07 0.5722307746212906 0.1387861728017405 1.7180968515068496e-11 10.764952358031309 -0.086433387384109 DRSFS(ph)EGGER ddPTM_A459_Selumetinib_30min_R1 1 DRSFSEGGER 10 1 G3V2D5;G3V515;G3V2P5;Q07352 G3V2D5 ZFP36L1 Zinc finger protein 36, C3H1 type-like 1 1 DRS(0.189)FS(0.811)EGGER 139.19 0.0073789 8094400.0 3934.1 4124.7 4491.9 5508.0 4774.1 4286.7 4776.9 4769.9 3127.8 3457.2 True False 4025.7568755739676 3641.7782064789926 3881.924652240525 4546.131197965272 4342.283497935812 4243.579690012183 4416.5745870957435 4643.386757181202 5307.648154526528 3900.9652959797263 1.0319899230384975 0.9335582170474964 0.9951189917636991 1.165386219316138 1.1131305121865354 1.0878281061319746 1.1321747957223296 1.190317371437937 1.3605986600282005 1.0 11.929615448484533 -5.8538663712638765 0.8456100947494023 1.1737814780620184 0.9554753156573171 0.35584054191249004 0.0932594110384339 0.8244428217920133 1.114111013659342 0.04315283348095753 0.12576483600362048 1.4000180300044951e-06 5.8538663712638765 -0.21830616240470124 DRSMS(ph)TAY(ph)MELS(ph)S(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 DRSMSTAYMELSSLR 15 1 A0A0A0MS14 A0A0A0MS14 IGHV1-45 4 DRS(0.416)MS(0.553)T(0.061)AY(0.975)MELS(0.997)S(0.997)LR 42.947 0.047959 0.0 3397.6 2666.0 3559.8 3914.0 2870.3 2504.0 2583.0 3306.9 3188.1 3816.8 True False 3208.7749936704313 2870.473627458886 3330.7663436171874 3380.906447973398 2509.7072531924273 2848.903270951161 2703.1146181173995 3316.522531513235 3825.8090829567163 3706.5990667626434 0.8656924948920862 0.7744224761719286 0.898604430536991 0.912131683809626 0.6770916433064379 0.7686030292559813 0.7292708408515057 0.8947616053898966 1.0321615621346907 1.0 11.855880355666075 -8.055064640644945 3.920292607419492 1.0107791814948146 0.8040869675622021 0.5907747428709742 0.07027687282272058 0.17319233556740593 5.2703143738437275 0.05451595587001395 0.019737657687077033 8.809177469366268e-09 8.055064640644945 -0.2066922139326125 DRSS(ph)FYVNGLTLGGQK ddPTM_A459_Selumetinib_30min_R1 1 DRSSFYVNGLTLGGQK 16 1 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 1 DRS(0.369)S(0.631)FYVNGLTLGGQK 110.16 0.001564 18230000.0 3374.9 8241.4 5056.1 6883.5 5072.8 5509.4 5655.3 5283.5 2169.3 4362.2 True False 3453.528603587753 7276.493056677089 4369.509391169288 5681.425944298108 4613.9661356755805 5453.980438134958 5228.716167891852 5143.364416773286 3681.1436605967124 4922.130861426228 0.7016328295235663 1.4783217394119963 0.8877271885256596 1.1542614579434136 0.9373920087810599 1.108052709625567 1.0622871100133222 1.0449467032826825 0.7478760244765355 1.0 12.265067298943528 -8.142767570849907 7.949896572157005 0.8750012625360301 1.0592649265019405 0.10677360131537683 0.19774588083686737 0.5267461081792343 31.740595141124388 0.12229643866229535 0.04587851634357295 7.198341214415074e-09 8.142767570849907 0.18426366396591043 DRSS(ph)FYVNGLTLGGQK ddPTM_A459_Selumetinib_30min_R2 3 DRSSFYVNGLTLGGQK 16 1 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 1 DRS(0.363)S(0.637)FYVNGLTLGGQK;DRS(0.233)S(0.76)FY(0.005)VNGLT(0.002)LGGQK;DRS(0.363)S(0.637)FYVNGLTLGGQK 123.58 0.00074539 19942700.0 212854.0 202040.0 208314.0 191484.0 237236.0 212758.0 195742.0 227809.0 170344.0 224347.0 True False 201024.42680207346 217535.81833900738 194911.3040351344 165403.54887167565 207432.29276325097 242063.4832751705 204844.3908554145 228471.88647419005 204417.55980903306 217869.51918649132 0.9226826568153443 0.9984683454173399 0.8946240151578744 0.7591862757547742 0.952094141198768 1.11104795282524 0.9402159219898604 1.0486638393809615 0.9382568088106731 1.0 17.733104846225864 -6.523075684703252 24.999988137168206 1.0092541972507751 0.8955785382142712 0.3578023646988201 0.07192520239415404 8.051846731833834 1021894.7178603045 0.02419265478302807 0.024423154354803415 2.998639899067366e-07 6.523075684703252 -0.1136756590365039 DRSS(ph)PPPGYIPDELHQVAR ddPTM_A459_Selumetinib_30min_R1 3 DRSSPPPGYIPDELHQVAR 19 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 DRS(0.152)S(0.848)PPPGYIPDELHQVAR;DRS(0.172)S(0.811)PPPGY(0.016)IPDELHQVAR;DRS(0.231)S(0.768)PPPGY(0.001)IPDELHQVAR 150.48 1.4514e-05 121141000.0 7038.7 8575.5 8748.5 9684.8 8093.0 6949.4 8126.200000000001 7337.1 4064.8 6691.2 True False 7202.6880150739635 7571.4764733582115 7560.501752070671 7993.531486211704 7360.989578935196 6879.4953455503455 7513.234191558848 7142.496273740378 6897.668718754208 7550.080697807343 0.9539882159359876 1.0028338472669678 1.0013802573350445 1.0587345759805118 0.9749550863837704 0.9111816973755332 0.9951197202091897 0.946015885077184 0.9135887409464901 1.0 12.882276349193086 -6.51834612419188 24.990793657492944 0.9513883591587422 1.0055446552526797 0.30968128485142954 0.035863210429502496 227.54009225768948 1254561.2649500782 0.011545223230270523 0.011820987766289336 3.031474195645128e-07 6.51834612419188 0.05415629609393746 DRT(ph)PPHLLYSDR ddPTM_A459_Selumetinib_30min_R1 1 DRTPPHLLYSDR 12 1 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 DRT(1)PPHLLYSDR 89.26 0.036024 11777000.0 701.73 860.47 653.56 652.72 779.15 618.63 753.47 755.87 500.3 562.71 True False 718.0789436711118 759.7257723783495 564.8101417481066 538.7347050718763 708.6760200701048 612.4071438710986 696.6351512778232 735.8218721882131 848.9725595337362 634.93930975956 1.1309410720577928 1.196532898027756 0.8895498090392134 0.8484822041903269 1.1161319029663914 0.9645128825036932 1.0971680923986675 1.1588853625504072 1.337092453537373 1.0 9.310474889229068 -7.61844076451838 3.0049936705336022 1.1879136426343788 1.022389079381138 0.19375635279756598 0.1267725111902669 0.3966177526667978 7.166530585820326 0.07153552530146148 0.03731386138276928 2.4074608616485124e-08 7.61844076451838 -0.16552456325324072 DRT(ph)PPHLLYSDRDR ddPTM_A459_Selumetinib_30min_R1 1 DRTPPHLLYSDRDR 14 2 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 DRT(1)PPHLLYSDRDR 98.105 0.013743 22527000.0 424.76 660.99 569.83 664.5 595.82 582.52 509.92 575.81 431.02 437.73 True False 434.6560815609158 583.6009835140858 492.45021585213823 548.4575492098627 541.9281862005649 576.660377685842 471.456323861053 560.5376483055221 731.4094595447355 493.91690935126866 0.880018629311176 1.1815772500694741 0.9970304853481189 1.110424726965169 1.0972051694127183 1.1675250771293741 0.9545255789689073 1.134882482646233 1.480835026493423 1.0 8.94812455031054 -8.010590813532684 24.573729077143767 1.262897946740708 1.0645746866390897 0.21368299011173286 0.139571208352793 501.8401828788932 1164406.2756687251 0.07683138530469706 0.03307804814675639 9.759086928403329e-09 8.010590813532684 -0.19832326010161827 DRVEEEHEDESR ddPTM_A459_Selumetinib_30min_R1 1 DRVEEEHEDESR 12 1 D4PHA4;Q86WP2-4;Q86WP2-3;Q86WP2;Q86WP2-2 D4PHA4 GPBP1 Vasculin 0 74.237 0.041371 319870.0 157.34 260.29 301.57 233.75 100.17 269.57 262.73 279.56 147.77 176.66 False True 161.0057158696546 229.81512579446186 260.6184504054356 192.9299505309337 91.1096411864499 266.85837054997666 242.9120645748635 272.14516066114106 250.75489730621683 199.3360318141208 0.8077100482254563 1.152903083817594 1.3074327206857423 0.967862903535871 0.4570655909886322 1.3387362441268014 1.2186059006199994 1.3652582435016776 1.2579506826946556 1.0 7.639058703870756 DRVTDALNATR ddPTM_A459_Selumetinib_30min_R1 1 DRVTDALNATR 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 131.17 0.0063504 4180400.0 2488.0 3922.7 3033.3 3133.7 2655.6 3192.4 3035.3 3000.3 1713.4 3000.3 False True 2545.9655591947426 3463.428460386244 2621.394520724236 2586.4581218343824 2415.40144888426 3160.287354467282 2806.3448772659494 2920.722297652102 2907.5146582152806 3385.417730396844 0.7520388211874522 1.0230431622334109 0.7743193689769421 0.7639996974704784 0.7134722037983545 0.9334999713895952 0.8289508417435343 0.8627361614573131 0.8588348291879647 1.0 11.725118145165206 -9.27307388183243 0.6218103067276802 1.0063716979874033 0.8263312377389859 0.26046254557295834 0.08661651911270007 4.103405314019993 2.226048146031209 0.15210503642731257 0.03574197052897331 5.332441726957345e-10 9.27307388183243 -0.18004046024841747 DRWPEVSPEDTQSLSLSEES(ph)PSKETSLDVSSK ddPTM_A459_Selumetinib_30min_R1 1 DRWPEVSPEDTQSLSLSEESPSKETSLDVSSK 32 2 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 DRWPEVSPEDTQS(0.002)LS(0.032)LS(0.058)EES(0.677)PS(0.194)KET(0.014)S(0.018)LDVS(0.004)S(0.001)K 71.15899999999998 3.9667e-05 12895000.0 1779.7 1953.3 2826.5 2763.6 1652.0 1782.5 1712.2 1793.6 910.57 1462.8 True False 1821.1635473066242 1724.6067279354663 2442.676824853147 2280.989139196956 1502.5768916842899 1764.5696683805074 1583.0473754998723 1746.0279015661135 1545.1707845985093 1650.5646288786131 1.1033579148875348 1.0448586488292537 1.4799037748147383 1.3819447595618541 0.9103411435062282 1.069070327515348 0.9590944503490229 1.0578367372093498 0.9361467933844505 1.0 10.688743913944874 -6.267408212638537 24.997676623158558 0.9941734904394227 1.2539255528006497 0.5180701496892461 0.12456190513946808 438.89613211557236 1838109.0317338258 0.041327105565452694 0.048098559227197926 5.402462827845569e-07 6.267408212638537 0.25975206236122694 DRYYLRNNYGS(ph)RY(ph)K ddPTM_A459_Selumetinib_30min_R1 1 DRYYLRNNYGSRYK 14 3 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 2 DRYYLRNNY(0.464)GS(0.543)RY(0.993)K 59.185 0.041661 17327000.0 1284.1 1587.3 2018.8 1848.1 1373.7 1813.4 1227.1 1464.6 1223.3 1195.3 True False 1314.0170315763532 1401.4581780842495 1744.658048474627 1525.3640281335554 1249.449077546433 1795.1588424354634 1134.5388590561229 1425.7540503087255 2075.850753703019 1348.7283982079628 0.97426363478538 1.0390959217188191 1.2935577324483793 1.1309645664466514 0.9263904276105991 1.331000996806078 0.841191496051814 1.0571098319002592 1.539116961177042 1.0 10.397384137759758 DS(ph)AAPSPIPGADNLSADPVVSPPTSIPFK ddPTM_A459_Selumetinib_30min_R2 1 DSAAPSPIPGADNLSADPVVSPPTSIPFK 29 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 DS(0.485)AAPS(0.412)PIPGADNLS(0.085)ADPVVS(0.016)PPT(0.001)S(0.001)IPFK 52.106 0.010744 6398900.0 27693.0 22945.0 32391.0 25580.0 27762.0 21050.0 24576.0 21338.0 18485.0 24592.0 True False 26153.933923862485 24704.807720196608 30306.998324654258 22095.959872038708 24274.289364571025 23949.446427125375 25718.83269642014 21400.09004730393 22182.516514053797 23881.965062310563 1.0951332461807106 1.0344545625009987 1.269032855779669 0.9252153168463324 1.0164276390672562 1.0028256202803558 1.0769144259828283 0.8960774371568185 0.9288396686025323 1.0 14.543633929259904 -5.787578099258536 24.99961035662739 0.980464385149853 1.1230318615603725 0.47963709964604573 0.0736593558720481 197.819964031102 189198.27815200252 0.02095060114012455 0.031085625399266494 1.630879601469714e-06 5.787578099258536 0.14256747641051948 DS(ph)DGVDGFEAEGK ddPTM_A459_Selumetinib_30min_R1 2 DSDGVDGFEAEGK 13 0 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 1 DS(1)DGVDGFEAEGK;DS(1)DGVDGFEAEGK 201.3 9.7435e-05 15729100.0 4711.5 5116.3 3800.5 3451.9 3117.1 3359.1000000000004 4491.0 4441.5 2729.0 3493.8 True False 4821.268783016892 4517.281217496662 3284.412974652178 2849.09046518815 2835.158855368701 3325.3105038187746 4152.240254275155 4323.696991974739 4630.913681726101 3942.2632624939174 1.2229697668559318 1.1458598568171174 0.833128778054874 0.7227042628771031 0.7191703512908343 0.8435029023696271 1.0532630567265577 1.0967550120535385 1.1746840262505795 1.0 11.944808406759483 -7.405849311713561 4.724269714066852 1.0972742967208526 0.9043646934005811 0.20929672441782565 0.15863610200006223 0.394418903233919 13.568941650920468 0.07930481199313273 0.05194566280201469 3.9278119607250795e-08 7.405849311713561 -0.19290960332027152 DS(ph)DGVDGFEAEGK ddPTM_A459_Selumetinib_30min_R2 3 DSDGVDGFEAEGK 13 0 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 1 DS(1)DGVDGFEAEGK;DS(1)DGVDGFEAEGK;DS(1)DGVDGFEAEGK 160.46 0.00036396 20212200.0 115304.0 84157.0 91439.0 95228.0 93687.0 81355.0 113569.0 111415.0 83364.0 86844.0 True False 108895.8652784835 90611.5712925948 85555.91429125555 82257.7821225371 81917.2014875932 92560.91278284014 118850.18353270428 111739.19920425383 100039.12938477557 84336.58807218999 1.2912054870570693 1.0744040441265372 1.014457855682066 0.9753510783733214 0.9713127286756509 1.097517873305597 1.4092363261242147 1.3249196079477144 1.1861889563180408 1.0 16.36387103656014 -7.048277973935789 12.041609551131486 1.2567024071835615 1.0556621197814382 0.25622368536283435 0.130339176847245 1.616488384249397 401.51901941538057 0.049875711022043905 0.03870834890371344 8.94791862959932e-08 7.048277973935789 -0.20104028740212332 DS(ph)GDENEPIQER ddPTM_A459_Selumetinib_30min_R2 1 DSGDENEPIQER 12 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7 Q8WX93 PALLD Palladin 1 DS(1)GDENEPIQER 106.76 0.0087674 2310700.0 6077.3 6201.9 9184.3 7142.3 10605.0 8357.8 8076.7 9907.2 7992.4 7864.7 True False 5739.547995359459 6677.565787748409 8593.392137109755 6169.506418845272 9272.705090097097 9509.011085445536 8452.282553677436 9936.028311774751 9591.103326314498 7637.625676055377 0.7514832801185115 0.874298646067869 1.1251392123144748 0.8077780557100634 1.2140821615764488 1.2450218809828708 1.1066636297948038 1.3009315634471412 1.2557702790257768 1.0 12.898908499132585 -5.284737392450824 0.6165330064557214 1.2099107393454127 0.6418779278456938 0.5372078668300531 0.1285355450902993 1.603624157314785 0.7009320187842425 0.06912110120484205 0.5937322525654072 5.1911383984402385e-06 5.284737392450824 -0.568032811499719 DS(ph)GGKTPGDFSYAYQKPEETTR ddPTM_A459_Selumetinib_30min_R2 2 DSGGKTPGDFSYAYQKPEETTR 22 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DS(0.581)GGKT(0.225)PGDFS(0.096)Y(0.084)AY(0.014)QKPEETTR;DS(0.794)GGKT(0.204)PGDFS(0.001)YAYQKPEETTR 63.706 0.0032650999999999995 22837000.0 42808.0 50554.0 35393.0 43575.0 39896.0 37915.0 45056.0 40574.0 29742.0 39144.0 True False 40428.90273400159 54431.329243269516 33115.85291298475 37640.00982893227 34883.90780523467 43137.44709189825 47151.19327677024 40692.063622612724 35691.23106091362 38013.81101167392 1.0635319547831183 1.4318829865954201 0.8711531948957967 0.9901667006597455 0.9176640509556364 1.1347835416620258 1.2403700660870403 1.0704547252606775 0.9389016810220095 1.0 15.214236047002174 -5.265479921828033 24.999417625336235 1.0301400384542554 1.2477074644706978 0.320807520278206 0.13167075536860354 393.4390711943373 2434280.1709089987 0.035291732563599645 0.07791892834900058 5.4265033839646136e-06 5.265479921828033 0.2175674260164424 DS(ph)GLESPAAAEAPLR ddPTM_A459_Selumetinib_30min_R1 1 DSGLESPAAAEAPLR 15 0 H0YM15;J3KNL7;Q8NBR6-2;Q8NBR6 H0YM15 FAM63B Protein FAM63B 1 DS(0.589)GLES(0.411)PAAAEAPLR 88.706 0.01735 2069800.0 858.38 1098.0 1008.6 1251.4 934.35 1301.1 1163.4 1091.7 555.88 748.47 True False 878.3785838832724 969.4456495536486 871.6376598432284 1032.8664816873172 849.8382074728908 1288.0121153042796 1075.643801341287 1062.744569658634 943.2877601311487 844.5434152151875 1.0400632673921966 1.1478932072504957 1.0320815296643304 1.2229880229711405 1.0062694139369428 1.5250987599922232 1.273639438734142 1.258365822895972 1.11692038933345 1.0 9.722027778941936 DS(ph)GRLSPDLSVCGQPR ddPTM_A459_Selumetinib_30min_R1 1 DSGRLSPDLSVCGQPR 16 1 Q8TF76-2;Q8TF76 Q8TF76-2 GSG2 Serine/threonine-protein kinase haspin 1 DS(0.97)GRLS(0.03)PDLSVCGQPR 62.69 0.035422 6659500.0 2045.1 2170.1 2340.3 2081.3 2390.8 1847.7 1940.5 1844.0 1020.5 1613.0 True False 2092.7468509281207 1916.02368314788 2022.5001143477166 1717.8400258397114 2174.552562130023 1829.1138155773717 1794.1265226944881 1795.091129843842 1731.7139656289785 1820.0442619505086 1.1498329434501564 1.0527346632188561 1.111236774088252 0.943845191983811 1.1947800433158666 1.004983150034573 0.985759830242675 0.9862898212816403 0.9514680504380327 1.0 10.829757820646511 -6.978737143864282 24.99965682547369 0.9819703899023238 1.0832434567990292 0.41291877369325236 0.06269715726823365 243.34543517690435 286110.8074795625 0.021088240648514636 0.01859654422370251 1.0501778550346599e-07 6.978737143864282 0.10127306689670545 DS(ph)GRLSPDLSVCGQPR ddPTM_A459_Selumetinib_30min_R2 2 DSGRLSPDLSVCGQPR 16 1 Q8TF76-2;Q8TF76 Q8TF76-2 GSG2 Serine/threonine-protein kinase haspin 1 DS(0.764)GRLS(0.236)PDLSVCGQPR;DS(0.994)GRLS(0.006)PDLSVCGQPR 111.66 0.0014201 41934000.0 33102.0 35658.0 33914.0 40673.0 34926.0 25458.0 33522.0 35687.0 18344.1 32993.0 True False 31262.323357805075 38392.853941458714 31732.010162771297 35133.26723516147 30538.28363759842 28964.608415285395 35080.83942258287 35790.84326169911 22013.432576978856 32040.406363891205 0.9757155699821893 1.198263639525077 0.9903747724789327 1.0965300138875842 0.9531178628250594 0.9040025300031099 1.094893710902436 1.1170533499236315 0.6870522279576168 1.0 14.967604824906962 -6.411021601164913 0.4982590349640941 0.9421502601664792 1.0945019293893563 0.12092892225417973 0.12625659134304743 2.8189740917414237 1.4149846762534293 0.10777661684322933 0.2041788181615409 3.881310604459006e-07 6.411021601164913 0.15235166922287713 DS(ph)HSPDLQLPTPEVIPSSGSK ddPTM_A459_Selumetinib_30min_R1 2 DSHSPDLQLPTPEVIPSSGSK 21 0 H3BQK9;H3BPE1;H0Y4F5;H0Y6T5 H3BQK9 MACF1 1 DS(0.553)HS(0.447)PDLQLPTPEVIPSSGSK;DS(0.558)HS(0.442)PDLQLPTPEVIPSSGSK 155.87 1.2865e-07 31359000.0 15305.4 19062.2 13687.6 14436.3 16749.0 14408.8 18196.0 15746.1 8559.2 15515.7 True False 15661.986040875885 16830.388762223633 11828.89910060496 11915.27120791323 15234.055907276115 14263.860554143654 16823.46107031636 15328.462277458848 14524.337260765853 17507.291230716364 0.8945979040662264 0.9613359679934316 0.6756555851342255 0.6805890786238826 0.8701549375352893 0.8147382919590584 0.9609402647509381 0.8755473405597559 0.8296164763217654 1.0 14.095668263416938 -7.231296197761317 20.34054859140505 0.9061548787874023 0.8126794073692009 0.21394038462638632 0.09324364302811991 131.33794187316184 88625.72219223646 0.0383823072215259 0.029716792097361052 5.8708880932344545e-08 7.231296197761317 -0.09347547141820145 DS(ph)HSPDLQLPTPEVIPSSGSK ddPTM_A459_Selumetinib_30min_R2 3 DSHSPDLQLPTPEVIPSSGSK 21 0 H3BQK9;H3BPE1;H0Y4F5;H0Y6T5 H3BQK9 MACF1 1 DS(0.5)HS(0.5)PDLQLPTPEVIPSSGSK;DS(0.5)HS(0.5)PDLQLPTPEVIPSSGSK;DS(0.5)HS(0.5)PDLQLPTPEVIPSSGSK 158.91 8.709799999999999e-08 32240400.0 167038.0 113693.0 147399.0 140509.0 149216.0 100861.0 119235.0 125626.0 95918.0 105426.0 True False 157754.69666609407 122412.88751938601 137915.5088158969 121371.43180845538 130470.15207203486 114753.68722500204 124779.66375967026 125991.55086149619 115104.28017284352 102382.0774503557 1.5408428955017848 1.1956476227857664 1.3470669110301174 1.1854753764623254 1.274345621041914 1.1208376513032297 1.2187647180745573 1.23060162480673 1.1242620099075125 1.0 16.64360366012096 -1.5228787452803376 0.15042428246731915 1.0134605931103982 2.4427124513418264 0.6130155139657179 0.08601697603860052 49.859508273605734 0.4931249720392769 0.2912865901723334 15.553571140011442 0.029999999999999995 1.5228787452803376 1.4292518582314282 DS(ph)LGAYASQDANEQGQDLGKR ddPTM_A459_Selumetinib_30min_R1 1 DSLGAYASQDANEQGQDLGKR 21 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DS(0.974)LGAY(0.026)ASQDANEQGQDLGKR 147.08 1.5065e-06 32430000.0 1076.0 1519.1 1323.5 1353.9 1458.5 1682.9 1821.1 1328.7 1027.1 1200.2 True False 1101.0687064684646 1341.2430657895704 1143.7759694651131 1117.4667808506147 1326.5789325190888 1665.9715539509423 1683.7329608239793 1293.4585597741393 1742.913683584052 1354.2573609380047 0.813042438038385 0.9903900871992158 0.8445779971045496 0.825150974314527 0.9795619139926661 1.2301735268376417 1.2432887642994006 0.9551054305351871 1.2869885251181878 1.0 10.403286217125027 -6.566771248940282 4.82777273348119 1.1453749930644306 0.8774336426239708 0.5938461923736092 0.10738241058887069 0.13801678159397146 7.300898566017254 0.03472639372442633 0.0352986519141539 2.711619516734936e-07 6.566771248940282 -0.26794135044045975 DS(ph)LGTYSSR ddPTM_A459_Selumetinib_30min_R1 4 DSLGTYSSR 9 0 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DS(0.857)LGT(0.142)YSSR;DS(0.998)LGT(0.002)YSSR;DS(0.561)LGT(0.433)YS(0.006)SR;DS(0.897)LGT(0.098)YS(0.005)SR 155.53 0.00082538 124933000.0 11418.1 15367.5 10619.5 10810.1 12549.4 11630.4 13523.399999999998 12135.3 7461.500000000001 12216.8 True False 11684.11951424496 13568.265955843077 9177.430228738012 8922.31896570886 11414.308985776517 11513.408735558289 12503.319050248188 11813.432422990214 12661.6205336018 13784.94528170922 0.8475999922718753 0.9842814518710025 0.66575746520483 0.6472509526423428 0.8280271522674653 0.8352161361739349 0.9070271078143793 0.856980726551382 0.9185107575582528 1.0 13.750805920240794 -8.050196011663346 0.742540206016521 0.9890901513264341 0.7949114638730572 0.32459484134736527 0.09161729121185255 0.8611738630533616 0.9810040579599418 0.09602482129715066 0.04111218865185836 8.908487774592182e-09 8.050196011663346 -0.19417868745337685 DS(ph)LGTYSSR ddPTM_A459_Selumetinib_30min_R2 1 DSLGTYSSR 9 0 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DS(0.999)LGT(0.001)YSSR 117.14 0.0076278 70660000.0 43153.0 38176.0 48524.0 53555.0 55936.0 43501.0 47466.0 47053.0 45509.0 46297.0 True False 40754.729015146 41103.97644481261 45402.018668936544 46260.71661247199 48908.81960581533 49492.86788723904 49673.26305209467 47189.916439956534 54612.07162770217 44960.28531594794 0.9064606402906837 0.9142285498404643 1.009824967743964 1.0289240000899809 1.0878227142492531 1.1008130295312724 1.1048253520418603 1.0495911248858938 1.2146736001323957 1.0 15.456363570415164 -5.517206461230955 1.0159916691561124 1.0995130943894322 0.8800860432723604 0.6524197909652113 0.05174886648112519 0.4368826035642062 0.7432185248560601 0.017941690698691535 0.08086311784735091 3.039439749065288e-06 5.517206461230955 -0.21942705111707184 DS(ph)LSPVLHPSDLILTR ddPTM_A459_Selumetinib_30min_R1 1 DSLSPVLHPSDLILTR 16 0 Q9HCN4-3;Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5 Q9HCN4-3 GPN1 GPN-loop GTPase 1 1 DS(0.53)LS(0.47)PVLHPSDLILTR 65.25 0.037187 5314300.0 1398.6 1416.9 1536.4 1418.3 2318.7 1329.9 2018.1 1248.2 273.51 1030.5 True False 1431.1846587981365 1251.0086893010603 1327.7653188411018 1170.6205297883353 2108.973994399734 1316.522413452587 1865.8730922183681 1215.0936812749899 464.1264936199726 1162.7747129200238 1.2308357267282386 1.075882262832719 1.1418938716913998 1.0067474952638147 1.8137425685011348 1.1322248401381756 1.6046729185679356 1.0449949313255873 0.39915427164255457 1.0 10.183355887030125 -8.006600766273621 23.913385891572045 0.707076110369379 1.279934249481301 0.4280105265770263 0.27029222795486874 146.22273880044625 529733.4168595943 0.15304218543427642 0.06905934563555968 9.849160931832659e-09 8.006600766273621 0.5728581391119221 DS(ph)PDPTPQVSATITVMAAHPEEDHR ddPTM_A459_Selumetinib_30min_R2 1 DSPDPTPQVSATITVMAAHPEEDHR 25 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 DS(0.868)PDPT(0.132)PQVSATITVMAAHPEEDHR 73.389 0.0034936 0.0 5124.7 4107.8 5290.8 5225.4 6528.1 4847.6 4998.7 5117.0 4137.9 3835.0 True False 4839.889689799518 4422.85505134119 4950.395688187481 4513.691505682215 5707.98171604553 5515.312897868548 5231.149454736143 5131.889622835045 4965.595622586054 3724.2735854733633 1.2995526721446158 1.1875752277149199 1.329224498301264 1.2119656094246136 1.5326429664860493 1.4809097052862028 1.404609337815673 1.3779572056285363 1.333305813502666 1.0 11.862743341959428 -6.219481113577097 24.99161386265699 1.3825877306128749 1.2572681113711908 0.08594119749538232 0.13977389419429553 910.6194723303488 542392.2521368316 0.03924107973477454 0.050659773794679314 6.032799425504861e-07 6.219481113577097 -0.1253196192416841 DS(ph)PGIPPSAGAHQLFR ddPTM_A459_Selumetinib_30min_R2 2 DSPGIPPSAGAHQLFR 16 0 E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q5SVM6 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 DS(1)PGIPPSAGAHQLFR;DS(1)PGIPPSAGAHQLFR 103.75 0.0028012 7119100.0 28689.0 20041.2 29120.0 32444.0 31723.0 25036.0 29722.0 36922.0 36142.0 45833.0 True False 27094.580231166397 21578.295597385244 27246.450903458735 28025.071230978254 27737.673132781732 28484.481745820012 31104.131893025693 37029.43690723387 43371.409891854615 44509.68220156471 0.6087345245123746 0.4848000374315562 0.6121466062164088 0.6296398860828768 0.6231829067475713 0.6399614721315322 0.6988172090775396 0.8319411659589904 0.974426411211939 1.0 15.44183157955636 -7.85470394594853 1.0334059610501958 1.0173247361441395 0.5848125792996228 0.9417341534220478 0.038806434769170714 0.11726103744835215 0.22711603703104935 0.03660503082991991 0.014126677582501322 1.3973205754296273e-08 7.85470394594853 -0.4325121568445167 DS(ph)PGIPPSANAHQLFR ddPTM_A459_Selumetinib_30min_R1 1 DSPGIPPSANAHQLFR 16 0 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 DS(1)PGIPPSANAHQLFR 86.214 0.010381 12679000.0 4406.3 5222.9 3070.1 3398.6 3494.9 4327.3 5137.8 4895.3 2005.8 3963.5 True False 4508.958216832713 4611.4004399396645 2653.197282852165 2805.0983096232358 3178.7869120747087 4283.771290874038 4750.2516095334895 4765.460741824599 3403.696102164239 4472.253832759354 1.0082071334602027 1.031113307156463 0.5932573109820911 0.6272225178892645 0.7107796272183898 0.9578551332429573 1.0621605542015071 1.0655613299311184 0.7610695254442164 1.0 12.126786358547706 -6.845231003346572 6.85238634728639 0.9813822751112803 0.7872497398065383 0.24063258396709641 0.15495971865456298 0.34095828722767746 23.08998332909386 0.06026778526644735 0.05326052437735514 1.428134124964427e-07 6.845231003346572 -0.19413253530474195 DS(ph)PGIPPSANAHQLFR ddPTM_A459_Selumetinib_30min_R2 7 DSPGIPPSANAHQLFR 16 0 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 DS(1)PGIPPSANAHQLFR;DS(1)PGIPPSANAHQLFR;DS(0.733)PGIPPS(0.267)ANAHQLFR;DS(1)PGIPPSANAHQLFR;DS(0.991)PGIPPS(0.009)ANAHQLFR;DS(1)PGIPPSANAHQLFR;DS(1)PGIPPSANAHQLFR 123.59 0.00089596 55884700.0 170694.5 131353.9 178369.6 247236.0 257830.0 205885.8 197821.0 270681.0 252950.0 241450.7 True False 161207.98303422346 141428.321760642 166893.49413013662 213562.03029411144 225439.09037055486 234244.70010479118 207020.06847487498 271468.63689634803 303547.06801351905 234479.39092674144 0.687514507765801 0.6031588584466622 0.7117618886270447 0.910792327846138 0.961445223307446 0.9989990982959198 0.8828923840882648 1.157750520518723 1.294557559254137 1.0 17.839101600101166 -6.028683168337461 0.5778271374514247 1.130252619111137 0.553788827503318 0.7478731357719555 0.10172558435974385 0.6252197829493227 0.3893205561557225 0.0745222468278021 0.20423620178674695 9.360883313716354e-07 6.028683168337461 -0.576463791607819 DS(ph)PPPPAR ddPTM_A459_Selumetinib_30min_R1 1 DSPPPPAR 8 0 O96013;O96013-2;O96013-4;M0R2X4 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 DS(1)PPPPAR 99.013 0.018995 1817500.0 2018.9 2695.4 2140.0 2040.9 2149.7 1932.3 2165.5 2397.9 1486.3 1918.5 True False 2065.936441904446 2379.8213149425374 1849.3997541785732 1684.4951274377866 1955.2600145603612 1912.862816388025 2002.1545915459474 2334.2999025230743 2522.142544943018 2164.7581627725053 0.9543497640671816 1.0993474263631327 0.8543216447836196 0.7781447167661334 0.9032233014223491 0.8836381122305753 0.9248860339123036 1.0783190208801103 1.165092058926709 1.0 11.079990147093662 -7.764139161467495 4.812259555305398 1.0946805451504016 0.911033893183409 0.44492750420473015 0.08542498028801108 0.17708916905304778 10.747060140496831 0.04964448451008382 0.025016609242665414 1.721316923096983e-08 7.764139161467495 -0.1836466519669926 DS(ph)PQSLTDESCSEK ddPTM_A459_Selumetinib_30min_R2 2 DSPQSLTDESCSEK 14 0 Q9BV36;Q9BV36-4;Q9BV36-2 Q9BV36;Q9BV36-2 MLPH Melanophilin 1 DS(1)PQSLTDESCSEK;DS(0.972)PQS(0.009)LT(0.017)DES(0.002)CSEK 180.1 7.3364e-05 8053900.0 46516.0 33468.0 38509.0 43340.0 37730.0 33226.0 38687.0 34429.0 23827.0 35156.0 True False 43930.82693830165 36034.8879834186 36031.372865429024 37437.017234329855 32990.02008952035 37802.579904402286 40486.022156836196 34529.1826899722 28593.065782004855 34140.954933742294 1.2867486285476977 1.0554739330915577 1.0553709741088229 1.096542768267152 0.9662887330932725 1.1072502212596615 1.1858491432183969 1.0113713209540665 0.8375004693774886 1.0 15.059215791134408 -4.759565966292662 5.006904908584163 1.041798110888783 1.302802634434549 0.42027307086050736 0.08850407234762879 0.18801274519477149 12.4035847476516 0.02283320199815183 0.1735318569725408 1.7395384542522782e-05 4.759565966292662 0.26100452354576587 DS(ph)PVIVR ddPTM_A459_Selumetinib_30min_R1 1 DSPVIVR 7 0 I3L2J0 I3L2J0 CIC 1 DS(1)PVIVR 118.33 0.010946 4019100.0 3037.9 3316.1 2153.8 2084.8 2585.7 2149.7 2673.1 2874.1 1590.0 2674.8 True False 3108.6771592756054 2927.849470386934 1861.325789976546 1720.728816542848 2351.8238915424117 2128.075969771432 2471.4659148748433 2797.8695316074736 2698.1138709946867 3018.1366347583503 1.0299988156515334 0.9700851302318044 0.6167135604599872 0.5701295285064587 0.7792304246460043 0.7050959672479568 0.8188714475057963 0.927018843145081 0.8939667740425918 1.0 11.559442404584415 -7.683760354969198 3.276569264912055 0.93671573641624 0.7697553567076733 0.2222986333285244 0.13471083405155124 0.4254465769190331 9.073557049689136 0.08282468376410236 0.04198076657645463 2.0712839743772583e-08 7.683760354969198 -0.1669603797085667 DS(ph)PVIVR ddPTM_A459_Selumetinib_30min_R2 2 DSPVIVR 7 0 I3L2J0 I3L2J0 CIC 1 DS(1)PVIVR;DS(1)PVIVR 118.5 0.010829 6184900.0 71510.0 45736.0 61927.0 76121.0 71423.0 54557.0 65350.0 68422.0 52617.0 53397.0 True False 67535.76047721111 49243.804135581275 57942.68424101959 65753.18848395081 62450.20421027859 62071.73153086365 68388.9044885683 68621.09669212817 63141.87024181597 51855.289867932544 1.3023890262539137 0.9496389714722968 1.1173919649970274 1.2680131313779959 1.2043169437357244 1.1970183117084259 1.3188414270317326 1.3233191226371612 1.2176553328045916 1.0 15.662203548471437 -5.71594699903613 7.782499392009276 1.2345738714342775 1.1048579510760301 0.10625892276965498 0.1170345519388301 0.37252646895543035 54.1502058580703 0.030339878720962863 0.052316988030707695 1.9233264358641055e-06 5.71594699903613 -0.12971592035824742 DS(ph)QDGSSYR ddPTM_A459_Selumetinib_30min_R1 1 DSQDGSSYR 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3;J3KSN1 Q14847 LASP1 LIM and SH3 domain protein 1 1 DS(1)QDGSSYR 168.82 0.00074403 4188300.0 1196.4 2269.7 1444.0 1398.3 1298.0 1525.5 1672.1 1815.7 1085.8 1510.0 True False 1224.273792210848 2003.9624688450976 1247.9127313242325 1154.1131543418373 1180.5961291805131 1510.1548550431773 1545.9721507845666 1767.541737775196 1842.523296305679 1703.8232086455484 0.718545084958716 1.1761563398576689 0.7324191412536626 0.6773667294151356 0.6929099939418164 0.8863330698750562 0.9073547906496324 1.0373973830185705 1.0814052109141006 1.0 10.734559931703311 -7.526095433185664 1.9560835330001651 1.0492293661127856 0.8128293447391085 0.35399349513029743 0.13709410439517822 0.4206412341687923 3.17213987055163 0.0880979149778003 0.04467667151669608 2.97786199310858e-08 7.526095433185664 -0.2364000213736771 DS(ph)QDGSSYR ddPTM_A459_Selumetinib_30min_R2 1 DSQDGSSYR 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3;J3KSN1 Q14847 LASP1 LIM and SH3 domain protein 1 1 DS(1)QDGSSYR 104.41 0.014373 83598000.0 20824.0 18085.0 21457.0 22696.0 19261.0 17660.0 24131.0 26738.0 16284.0 27048.0 True False 19666.68544507683 19472.06134755962 20076.479980615182 19604.765647216213 16841.260984475277 20092.504698481443 25253.13931466937 26815.803153285804 19541.2550129755 26267.053960856218 0.7487206397178986 0.7413112021080607 0.7643217244893022 0.7463633217654213 0.6411553046478878 0.76493179358537 0.9613997577460416 1.0208911586829397 0.7439454398691356 1.0 14.68096678046251 -7.189540591770498 5.0396040797846 0.9331263651315881 0.7301808590761589 0.6137006875500947 0.07685389535123152 0.14552698377661613 6.964252553326473 0.029445806111957736 0.022427926417669865 6.463375805843204e-08 7.189540591770498 -0.20294550605542916 DS(ph)QSASGEERPPEADGK ddPTM_A459_Selumetinib_30min_R2 1 DSQSASGEERPPEADGK 17 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 DS(0.786)QS(0.213)ASGEERPPEADGK 91.926 0.038763 4300900.0 16091.0 12988.0 15594.0 13719.0 15625.0 15485.0 18168.0 16004.0 16125.0 14324.0 True False 15196.726637376638 13984.137836997761 14590.699017463443 11850.448533404973 13662.04781072769 17617.918191165634 19012.847999209043 16050.568990395172 19350.4505701443 13910.428901778487 1.0924700269618355 1.0052988254883968 1.0489036046615343 0.8519110817560672 0.9821442535809202 1.2665258789334048 1.3668053036652377 1.1538514810526843 1.3910750492869628 1.0 13.763879282889658 -6.760957181979246 24.99433900142713 1.2534644005797388 0.9915720190698759 0.5041739691297464 0.11805515920113183 9.768600323027988 506358.17069537495 0.038496382412113304 0.03628690082716676 1.7339749456211197e-07 6.760957181979246 -0.26189238150986294 DS(ph)SGSVSPNTLSQEEGDQICLYHIR ddPTM_A459_Selumetinib_30min_R2 1 DSSGSVSPNTLSQEEGDQICLYHIR 25 0 H7C4T3;H7C4L8;G5E9U9;Q9H0J9 H7C4T3 PARP12 Poly [ADP-ribose] polymerase 12 1 DS(0.412)S(0.112)GS(0.024)VS(0.412)PNT(0.04)LSQEEGDQICLYHIR 136.16 2.7335e-08 8547700.0 28977.0 29495.0 31072.0 39416.0 40333.0 28473.0 29857.0 27671.0 29354.0 32883.0 True False 27366.57434412173 31757.171658627114 29072.861348635637 34047.47280360741 35266.00795840511 32394.89729784041 31245.40966052314 27751.51802881936 35225.620219287826 31933.582349705503 0.8569841630804103 0.9944756999341161 0.9104165336121067 1.0661964708735974 1.1043548942366106 1.014446075704349 0.9784498750673768 0.869038672984188 1.1030901523521892 1.0 14.962786784892604 -3.8128836004434876 1.0805150640124166 1.008728118762314 1.2299254698247978e-13 0.28330581337770855 0.07142484657615332 16.85525907616898 3.310023700448485 0.022844237449280793 31.860973232368153 0.0001538566951582117 3.8128836004434876 -1.008728118762191 DS(ph)SKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVK ddPTM_A459_Selumetinib_30min_R2 1 DSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAENVK 45 2 Q12906-7;Q12906-4;Q12906-6 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 DS(0.255)S(0.255)KGEDS(0.255)AEET(0.231)EAKPAVVAPAPVVEAVS(0.001)T(0.001)PSAAFPSDATAENVK 53.094 0.00013371 3832600.0 82678.0 79912.0 73632.0 72699.0 57577.0 54634.0 64698.0 64621.0 42813.0 70533.0 True False 78083.08774625725 86040.99344242121 68894.59728446013 62797.270787229914 50343.66251508919 62159.33758192724 67706.58519665488 64809.036411417575 51376.79629516827 68496.52902325743 1.1399568541603733 1.2561365469074601 1.0058115099681553 0.9167949337390164 0.7349812206979921 0.9074815683116082 0.9884673889631059 0.9461652631976754 0.7500642299367272 1.0 16.06374326269112 -5.485931092247688 2.949061698308175 0.8884220330300876 1.1975426356404706 0.6528695934315063 0.08816092377977665 0.15507444757409272 2.674828575368779 0.024933193822343845 0.05614319988538617 3.2663965465644193e-06 5.485931092247688 0.309120602610383 DS(ph)SQEYTDSTGIDLHEFLVNTLK ddPTM_A459_Selumetinib_30min_R1 1 DSSQEYTDSTGIDLHEFLVNTLK 23 0 Q15032-2;Q15032-4;Q15032;Q15032-3;H7C2F9;A0A0U1RRA6;B5MCU0;B5MCG9;Q9Y2K5;H0YIX9 Q15032-2;A0A0U1RRA6 R3HDM1;R3HDM2 R3H domain-containing protein 1;R3H domain-containing protein 2 1 DS(0.499)S(0.444)QEY(0.002)T(0.038)DS(0.007)T(0.01)GIDLHEFLVNTLK 76.765 0.0047071000000000005 0.0 0.0 0.0 196.05 78.916 170.33 73.145 65.934 0.0 0.0 0.0 True False 0.0 0.0 169.427486825565 65.13480203678787 154.92368157420398 72.40922771034626 60.96054529623206 0.0 0.0 0.0 0.0 DS(ph)SVASSVYARTGHLVG ddPTM_A459_Selumetinib_30min_R1 1 DSSVASSVYARTGHLVG 17 1 Q6L980 Q6L980 SNCAIP 1 DS(0.842)S(0.116)VAS(0.021)S(0.021)VYARTGHLVG 58.07100000000001 0.029427 11464000.0 119.81 161.96 354.8 153.85 125.74 189.57 82.198 0.0 190.72 156.4 True False 122.60133989032236 142.9976479068387 306.6201087768961 126.98298562217816 114.36683920120008 187.6630979157884 75.99773868201052 0.0 323.63791036233107 176.47546346500897 0.694721733452942 0.8102976192789081 1.7374659499771865 0.7195503733432946 0.6480608519488399 1.0633948438559997 0.43064195548679846 0.0 1.8338974949143625 1.0 7.463323799910858 DS(ph)YGGPPR ddPTM_A459_Selumetinib_30min_R2 1 DSYGGPPR 8 0 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DS(1)YGGPPR 125.71 0.0050199 11804000.0 82500.0 56540.0 67983.0 80653.0 80605.0 82924.0 86483.0 101770.0 88041.0 72400.0 True False 77914.98027366675 60876.43619524582 63609.04779429386 69667.92226581466 70478.67928215709 94346.02829087623 90504.63086281352 102066.13385106948 105651.66007107447 70309.62388220915 1.108169493328523 0.8658336204049831 0.904699019594517 0.9908732036816248 1.0024044418191052 1.3418650688408695 1.2872296261239768 1.4516666171058248 1.5026628537805067 1.0 16.101434556427066 -6.735660796816389 4.455090486879072 1.345793215536221 0.9604726901924685 0.5984021655771554 0.13928784379430073 0.1272274696342132 5.843771244779003 0.0468656933199798 0.044813967442624954 1.8379733212762627e-07 6.735660796816389 -0.3853205253437526 DS(ph)YGGPPRR ddPTM_A459_Selumetinib_30min_R2 1 DSYGGPPRR 9 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DS(0.995)Y(0.005)GGPPRR 64.73 0.046372 2303100.0 6012.3 5316.3 7054.8 6790.3 5623.6 5644.0 7127.1 6722.6 5268.8 5437.3 True False 5678.160435143844 5724.043115401227 6600.901848685467 5865.449426079145 4917.113092378126 6421.409768869153 7458.524272080733 6742.161653013655 6322.707222572179 5280.311021198 1.0753458295067586 1.0840352192175513 1.2500971670391965 1.1108151399665827 0.9312165652057609 1.2161044573113535 1.4125160889459383 1.2768493420078861 1.1974118943352847 1.0 12.36640719445884 -6.980338057936145 24.826442123900758 1.254700170702239 1.0973398787555773 0.20662614258821588 0.12055067509863002 294.0877590282185 371332.9153062139 0.04235168153737718 0.03734592779813457 1.0463137728416859e-07 6.980338057936145 -0.15736029194666168 DS(ph)YVGDEAQSK ddPTM_A459_Selumetinib_30min_R1 2 DSYVGDEAQSK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 DS(0.999)YVGDEAQS(0.001)K;DS(1)YVGDEAQSK 206.46 1.7496e-05 27200000.0 5997.0 8448.8 7929.4 8157.1 8727.6 7358.299999999999 11888.0 20065.5 3241.8 7923.2 True False 6136.718431869317 7459.610568259441 6852.631033076431 6732.615612731032 7938.190120982931 7284.2821828018405 10991.278588916284 19533.297758070268 5501.097828295955 8940.219898503576 0.6864169451689313 0.8343878174079408 0.7664946847921976 0.7530704713267674 0.8879188891440617 0.814776623561697 1.2294192663824766 2.1848788933412897 0.6153201924280112 1.0 13.12609460181777 -7.31085740325921 4.512640123448329 1.3682955394930818 0.7923475469627755 0.25769618064372457 0.3743137872762896 0.24341526615191303 10.94922751329422 0.15212754231220552 0.10246215735606751 4.88812830353682e-08 7.31085740325921 -0.5759479925303063 DS(ph)YVGDEAQSK ddPTM_A459_Selumetinib_30min_R2 1 DSYVGDEAQSK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 DS(1)YVGDEAQSK 129.54 0.0025661 7263200.0 135930.0 99750.0 144060.0 171790.0 141040.0 103720.0 134460.0 110300.0 109070.0 116940.0 True False 128375.55477090355 107400.5042531972 134791.3364406683 148391.90564572066 123321.2942864021 118006.48852358393 140712.65642743555 110620.95473885191 130887.04767042697 113563.63835339124 1.130428336325577 0.9457296878687931 1.1869233708523848 1.3066850252186322 1.0859223610170594 1.0391221189688136 1.2390643560534849 0.9740878008383089 1.1525436272403333 1.0 16.79314145043554 -7.777916300791974 24.999866241817564 1.0474868471515797 1.1294618863777466 0.1365627623300043 0.1045071156179465 602.0592633404768 913471.0137790064 0.05848215772990008 0.028219949210330712 1.6675685629827308e-08 7.777916300791974 0.08197503922616689 DS(ph)YYVYTQQELK ddPTM_A459_Selumetinib_30min_R1 2 DSYYVYTQQELK 12 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 DS(1)YYVYTQQELK;DS(1)YYVYTQQELK 200.76 8.9869e-05 60593000.0 9457.9 14514.6 7267.4 7418.0 8025.4 10509.4 11304.7 10650.4 6985.700000000001 10056.1 True False 9678.250668130206 12815.223884345527 6280.526996970723 6122.585553105741 7299.5039869994525 10403.684977771727 10451.97737753382 10367.916794625186 11854.222684658853 11346.898389708927 0.8529423932189167 1.1294032469673208 0.553501651399897 0.539582301949458 0.6433038999996457 0.9168747811478908 0.921130781166882 0.9137225379605383 1.044710393759236 1.0 13.47001037844944 -6.893826927125476 6.138162791833867 0.9566172587186401 0.7439041213184905 0.309888151119866 0.16173648900918317 0.3198717606357637 16.31195970034506 0.06432704086071166 0.056706516740834975 1.2769475902216747e-07 6.893826927125476 -0.21271313740014963 DS(ph)YYVYTQQELK ddPTM_A459_Selumetinib_30min_R2 4 DSYYVYTQQELK 12 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 DS(0.999)Y(0.001)YVYTQQELK;DS(1)YYVYTQQELK;DS(1)YYVYTQQELK;DS(0.997)Y(0.001)Y(0.002)VYTQQELK 205.27 1.9063e-05 29651000.0 118758.0 76153.0 109965.0 123122.0 134261.0 108698.0 88922.0 113670.0 76469.0 99324.0 True False 112157.90578594102 81993.69022951128 102889.97162083912 106352.57120270337 117393.93287143102 123670.16283779926 93057.04919560037 114000.76088091834 91764.93672237944 96456.25804525583 1.1627851635434396 0.8500608658387003 1.0667008414587749 1.1025989744781965 1.217069117654881 1.2821372645388656 0.9647590636570142 1.1818907678072157 0.951363224969029 1.0 16.557587222364717 -4.42931800961819 22.982110237223914 1.0787571281431847 13.038297696879251 0.042333827703454285 0.12632238619418473 3582.535345312822 870960.8198581967 0.03114386640530647 23151.651233733213 3.7211912439562234e-05 4.42931800961819 11.959540568736067 DSAAPS(ph)PIPGADNLSADPVVSPPTSIPFK ddPTM_A459_Selumetinib_30min_R1 1 DSAAPSPIPGADNLSADPVVSPPTSIPFK 29 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 DS(0.021)AAPS(0.976)PIPGADNLS(0.003)ADPVVSPPTSIPFK 107.43 9.0115e-11 12122000.0 4623.2 4313.6 4893.3 5410.9 4719.0 3673.0 4491.9 4247.8 2498.8 3826.2 True False 4730.91156481878 3808.561706661768 4228.816736972902 4465.9878901725315 4292.16728320712 3636.052954817169 4153.072366550559 4135.1345452010155 4240.281094868878 4317.3300403441035 1.095795670150275 0.8821567197948607 0.9794981383067608 1.0344328203865043 0.994171685532066 0.8421994429055428 0.9619538760626111 0.9577990347180948 0.9821535660338157 1.0 12.075923669184318 DSAAPSPIPGADNLS(ph)ADPVVSPPTSIPFK ddPTM_A459_Selumetinib_30min_R1 1 DSAAPSPIPGADNLSADPVVSPPTSIPFK 29 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 DS(0.004)AAPS(0.103)PIPGADNLS(0.893)ADPVVSPPTSIPFK 106.51 1.0162e-10 8709300.0 4889.5 5585.7 6115.6 6332.4 5523.8 4186.7 4568.9 4424.1 2954.7 4330.2 True False 5003.415836689183 4931.72364727852 5285.135110586202 5226.5652138698815 5024.173265306101 4144.58559921945 4224.264194557507 4306.758496497907 5013.91009725031 4886.0233497198315 1.0240261821458718 1.0093532703975532 1.081684374449266 1.069697142190198 1.0282745099026576 0.848253334576697 0.8645607874141105 0.8814445180137872 1.0261739943461 1.0 12.254445042750374 -6.653828284108759 6.853757356865146 0.9133407753016034 1.0462059669269177 0.52334539125128 0.056229501786293955 0.16708721114045372 9.574650790385768 0.019008019715484215 0.01896393509942127 2.2190736468961238e-07 6.653828284108759 0.1328651916253143 DSAAPSPIPGADNLS(ph)ADPVVSPPTSIPFK ddPTM_A459_Selumetinib_30min_R2 1 DSAAPSPIPGADNLSADPVVSPPTSIPFK 29 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 DS(0.026)AAPS(0.381)PIPGADNLS(0.59)ADPVVS(0.002)PPTSIPFK 70.465 0.0002079 6000800.0 83817.0 70252.0 77808.0 85025.0 82985.0 63211.0 68954.0 68092.0 59048.0 72908.0 True False 79158.78668603548 75640.10250421656 72801.91799094494 73444.44832369407 72559.68240468728 71917.7414776733 72160.49762975895 68290.13644676251 70859.24993896947 70802.95660226665 1.1180152706151445 1.068318416829998 1.0282327389222938 1.0373076471405835 1.0248114752084292 1.015744891582267 1.0191735076137884 0.9645096719672339 1.0007950704236694 1.0 16.111521985427885 -1.5228787452804813 0.36760150246499995 0.9924545173982579 2.613291844884073 0.8623346726373768 0.01465811737749385 23.273328865361478 0.3223778108894372 0.012314702636826087 26.57864244404691 0.029999999999990073 1.5228787452804813 1.6208373274858152 DSAIPVES(ph)DTDDEGAPR ddPTM_A459_Selumetinib_30min_R1 2 DSAIPVESDTDDEGAPR 17 0 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 1 DSAIPVES(0.828)DT(0.172)DDEGAPR;DSAIPVES(0.937)DT(0.063)DDEGAPR 328.34 3.328499999999996e-250 38485000.0 11754.3 13665.2 14359.3 14927.3 13243.3 11856.099999999999 13206.2 12296.900000000001 7011.5 9281.900000000001 True False 12028.152320113635 12065.272031220868 12409.385929988954 12320.527275124732 12045.445853294514 11736.83839847749 12210.045701627376 11970.74626603944 11898.003400301408 10473.322278362324 1.1484562396178297 1.1520004551132241 1.1848566863665122 1.1763724010077201 1.1501074380361775 1.1206413864228704 1.1658235445359193 1.142975070171455 1.1360295314202684 1.0 13.354431536644336 -14.47401271505632 0.2649992785559907 7.501315846451481e-12 1.1652785115995252 0.8929417092496033 0.016118354846182854 61.804897614169796 0.6181566771472334 33.66631852278265 0.02204512709343337 3.3572778482913375e-15 14.47401271505632 1.165278511592024 DSAIPVES(ph)DTDDEGAPR ddPTM_A459_Selumetinib_30min_R2 2 DSAIPVESDTDDEGAPR 17 0 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 1 DSAIPVES(0.898)DT(0.102)DDEGAPR;DSAIPVES(0.941)DT(0.059)DDEGAPR 235.02 4.1678999999999995e-17 121225000.0 69324.0 67144.0 78708.0 82175.0 90884.0 64631.0 67206.0 68493.0 60667.0 70639.0 True False 65471.24960595983 72293.72889801186 73644.01297079085 70982.62324021825 79466.33940673115 73533.3335881968 70331.21216616263 68692.30329037338 72802.09517760885 68599.46852783654 0.954398787789335 1.0538526092031786 1.0735362029941575 1.0347401337579558 1.15841042375547 1.0719227884157467 1.0252442719381036 1.0013532869062853 1.0612632537825997 1.0 16.06590977875767 -10.416478856034718 11.229636028696218 0.9999999850013961 1.0506830880176292 0.0748974785653036 0.050305030838532265 0.0 0.0 0.05049496387873107 0.012246827625515098 3.8328440044550697e-11 10.416478856034718 0.05068310301623313 DSALAEAPEGLS(ph)PAPPAR ddPTM_A459_Selumetinib_30min_R1 4 DSALAEAPEGLSPAPPAR 18 0 Q9H9J4-2;Q9H9J4;C9JPC9 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 DSALAEAPEGLS(1)PAPPAR;DSALAEAPEGLS(1)PAPPAR;DSALAEAPEGLS(1)PAPPAR;DSALAEAPEGLS(1)PAPPAR 273.77 2.4068999999999997e-54 156509300.0 13001.3 15121.099999999999 16620.100000000002 17195.9 15203.4 12723.9 14682.6 14069.3 7758.200000000001 11963.099999999999 True False 13304.204993874033 13350.714582391316 14363.18170767444 14192.958872020894 13828.255154378285 12595.909118376845 13575.079660970927 13696.136460472862 13165.098763491178 13498.68041546195 0.9855930049751266 0.989038496466577 1.0640433928061779 1.0514330612467637 1.024415330148777 0.9331215148962981 1.0056597565952792 1.0146278035284648 0.9752878324618551 1.0 13.72053076081678 -6.595291893212296 24.99999801012996 0.9868840038846384 1.0249579471258095 0.2673618557449232 0.03063913156805699 63.85454357744082 22043.565543186018 0.010785159465799768 0.010785162466795027 2.539265468817189e-07 6.595291893212296 0.03807394324117108 DSALAEAPEGLS(ph)PAPPAR ddPTM_A459_Selumetinib_30min_R2 4 DSALAEAPEGLSPAPPAR 18 0 Q9H9J4-2;Q9H9J4;C9JPC9 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 DSALAEAPEGLS(1)PAPPAR;DSALAEAPEGLS(1)PAPPAR;DSALAEAPEGLS(1)PAPPAR;DSALAEAPEGLS(1)PAPPAR 297.7 1.7799999999999988e-95 120275000.0 164299.0 152718.0 173693.0 196952.0 193360.0 145767.0 137116.0 169650.0 123933.0 166267.0 True False 155167.91932100817 164430.97953423357 162517.78148263972 170126.79783884934 169068.38813966746 165845.08110892103 143492.1656901997 170143.65341293075 148723.06297734566 161466.43969645404 0.9609917677798144 1.018360099122472 1.0065112093148405 1.0536356543110519 1.0470806717328045 1.0271179659420158 0.8886810532266349 1.053740044883564 0.9210772421621171 1.0 17.300874810781153 DSAPSTPT(ph)SPTEFLTPGLR ddPTM_A459_Selumetinib_30min_R1 1 DSAPSTPTSPTEFLTPGLR 19 0 Q9NZJ4-2;Q9NZJ4 Q9NZJ4-2 SACS Sacsin 1 DSAPSTPT(0.923)S(0.072)PT(0.004)EFLTPGLR 196.65 7.2656e-15 13856000.0 2371.2 3719.8 3629.1 3775.6 3248.9 2940.6 3073.4 3136.7 1759.0 2337.8 True False 2426.4443464479796 3284.2840867118966 3136.2881532193705 3116.2623367897027 2955.037568639883 2911.020233851176 2841.570963591465 3053.5045265624594 2984.894527723051 2637.8794021003723 0.9198465799899568 1.2450470950631156 1.1889429633220334 1.1813513287637127 1.120232246510958 1.1035456099825183 1.0772179203222507 1.1575603206617981 1.131550792407861 1.0 11.36516289399423 -6.502371633833753 9.209422707757852 1.1037506849093204 1.1463411073097252 0.030385058117736397 0.08900560082014333 1.1334782616857977 479.2123659251308 0.027539572640313034 0.030124148545252534 3.1450558797021447e-07 6.502371633833753 0.04259042240040478 DSAPSTPT(ph)SPTEFLTPGLR ddPTM_A459_Selumetinib_30min_R2 2 DSAPSTPTSPTEFLTPGLR 19 0 Q9NZJ4-2;Q9NZJ4 Q9NZJ4-2 SACS Sacsin 1 DSAPST(0.002)PT(0.589)S(0.389)PT(0.019)EFLTPGLR;DSAPS(0.001)T(0.115)PT(0.685)S(0.165)PT(0.034)EFLTPGLR 183.88 1.5489e-14 4970600.0 31543.0 23382.1 32836.0 39785.0 32604.0 24660.9 27846.7 30150.0 27616.0 37822.0 True False 29789.966336633595 25175.431884698588 30723.367509133637 34366.21436704693 28507.994036541786 28057.715125638762 29141.62672718923 30237.731508398807 33139.9716555104 36729.98058664242 0.8110531467982126 0.6854191448675616 0.8364656615230228 0.9356447735108491 0.7761505337388955 0.7638913682367287 0.7934016370753856 0.8232438739538934 0.9022594383717808 1.0 15.164670513093506 -8.486886985635843 1.8504260222733968 0.9991491897155936 0.8000759987821309 0.5343342492121937 0.05916271159885419 0.2874900394429492 2.194073473757029 0.06040997333312804 0.017175669858892607 3.2592150295282496e-09 8.486886985635843 -0.19907319093346276 DSAPSTPTS(ph)PTEFLTPGLR ddPTM_A459_Selumetinib_30min_R2 2 DSAPSTPTSPTEFLTPGLR 19 0 Q9NZJ4-2;Q9NZJ4 Q9NZJ4-2 SACS Sacsin 1 DSAPSTPT(0.109)S(0.731)PT(0.153)EFLT(0.007)PGLR;DSAPST(0.001)PT(0.285)S(0.703)PT(0.011)EFLTPGLR 166.3 6.666e-09 7759200.0 55606.0 36479.1 45461.0 55077.0 47786.0 36383.8 36456.3 46761.0 36116.0 46748.0 True False 52515.64112845476 39276.92967120612 42536.0887541943 47575.41758687556 41782.695467739744 41395.33819074797 38151.59018678802 46897.06676829972 43340.20916535389 45398.26377410925 1.1567764218860848 0.8651636958329199 0.9369540863025856 1.0479567638004683 0.9203588858737044 0.9118264609572105 0.8403755345495387 1.0330145443809957 0.9546666670118544 1.0 15.470349503224673 -4.747813538516831 24.998878570846244 0.9444198847107832 1.1567769452340437 0.49727529799149817 0.0636920975294007 606.7024356094756 1113032.59438453 0.016080971875807214 0.315133609405596 1.7872547562382413e-05 4.747813538516831 0.21235706052326053 DSAS(ph)PSTSSFCLGVSVAASSHVPIQK ddPTM_A459_Selumetinib_30min_R2 1 DSASPSTSSFCLGVSVAASSHVPIQK 26 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 DS(0.012)AS(0.625)PS(0.174)T(0.174)S(0.012)S(0.003)FCLGVSVAASSHVPIQK 113.79 6.854100000000002e-09 1530400.0 31808.0 27010.0 45097.0 64459.0 72896.0 41080.0 33683.0 40128.0 48897.0 51982.0 True False 30040.238697512676 29081.58014916147 42195.50811790107 55679.57300202281 63738.15278149162 46738.39711288883 35249.32624159829 40244.765836451996 58677.76629633153 50481.144594544094 0.5950783988515064 0.5760879707213404 0.8358667073975473 1.1029776255913293 1.2626130665900217 0.925858505948778 0.6982671752931682 0.7972237190676056 1.1623699654122603 1.0 15.623457001481478 -5.409812170725643 3.465537490288823 0.9803068996497871 0.5851597704138463 0.5115718645777612 0.157095304004322 0.2213050214516329 4.838002173892797 0.0477501382447773 0.1097396309268147 3.892134406429879e-06 5.409812170725643 -0.39514712923594086 DSAVAISGADS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 DSAVAISGADSR 12 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 DSAVAISGADS(1)R;DSAVAIS(0.006)GADS(0.994)R 92.151 0.022061 7615500.0 35152.0 30883.0 33337.0 40319.0 40491.0 28604.0 31939.0 35288.0 29548.0 32984.0 True False 33198.39256460528 33251.62679550368 31192.1337145812 34827.482645845535 35404.15858586718 32543.941358740805 33424.22678592785 35390.68223775712 35458.4256401007 32031.666217276023 1.0364241541297028 1.0380860792552116 0.9737905453622008 1.087282890924407 1.1052861985297608 1.015992772214531 1.0434744967434995 1.1048654789824652 1.1069803674769962 1.0 14.967211225457199 -5.7814312775520245 24.99999938759566 1.069219401371289 1.0182988145885317 0.25387606208871394 0.03913041565736211 323.0026726107293 403915.7285541421 0.011266455594529177 0.016733505919915185 1.654126511858345e-06 5.7814312775520245 -0.05092058678275735 DSAYIS(ph)SSPLGSHQVFDFR ddPTM_A459_Selumetinib_30min_R1 1 DSAYISSSPLGSHQVFDFR 19 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 DS(0.003)AYIS(0.467)S(0.467)S(0.062)PLGSHQVFDFR 293.47 1.0360999999999993e-85 11466000.0 1710.3 1678.6 1773.0 1880.1 2257.8 1819.0 2099.5 1898.5 770.33 1363.2 True False 1750.1466623355175 1482.0687316400313 1532.2363383918741 1551.7758288479506 2053.582388646965 1800.7025115198549 1941.1330246828525 1848.145612802892 1307.1937473228522 1538.1799986924568 1.1378035495346739 0.963521000728053 0.9961359136735394 1.0088389071285877 1.3350728720908023 1.1706708662513865 1.261967407151913 1.2015145265014004 0.8498314556385101 1.0 10.587008622829345 -4.439207286923329 21.924425789798125 1.1011230616456773 3.643302386608721 0.0029235594380971897 0.14400177049619578 4283.028710877083 1241872.6595131613 0.03649985696003739 57726.472279629896 3.637413824616971e-05 4.439207286923329 2.5421793249630436 DSAYISS(ph)SPLGSHQVFDFR ddPTM_A459_Selumetinib_30min_R1 3 DSAYISSSPLGSHQVFDFR 19 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 DSAYISS(0.52)S(0.48)PLGSHQVFDFR;DSAYIS(0.03)S(0.563)S(0.407)PLGSHQVFDFR;DSAYIS(0.01)S(0.565)S(0.425)PLGSHQVFDFR 158.52 1.6187e-06 134668000.0 9126.3 10075.3 9467.8 10778.400000000001 12310.6 8974.099999999999 10793.3 10059.9 4133.9 7507.69 True False 9338.92503331148 8895.679192120106 8182.124762902748 8896.154775626164 11197.108403612963 8883.82870183086 9979.152691264317 9793.07877283951 7014.926371889893 8471.37514259344 1.1024095705968755 1.0500867972890606 0.9658555577079377 1.0501429373487385 1.3217580634948793 1.0486879110291827 1.1779849815751735 1.1560199622845932 0.8280741029421974 1.0 13.048380463235976 -8.254585642596563 24.99373382928796 0.9140370470608156 1.107778455635585 0.3828412270338136 0.0990633889415801 520.2600051091166 1897265.1896479302 0.07269377274702081 0.02612854953097028 5.564348948297645e-09 8.254585642596563 0.1937414085747694 DSAYISSS(ph)PLGSHQVFDFR ddPTM_A459_Selumetinib_30min_R1 1 DSAYISSSPLGSHQVFDFR 19 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 DSAYISS(0.321)S(0.678)PLGSHQVFDFR 160.52 1.1399e-06 21423000.0 2064.0 2391.2 2097.9 2384.4 3218.0 2053.6 2620.1 2823.0 1106.7 1688.4 True False 2112.087184155123 2111.2371923612795 1813.0167029398247 1968.0093007313728 2926.932468184044 2032.9426485196127 2422.463747545387 2748.1248696036673 1877.9890698300737 1905.122586408703 1.1086358427656686 1.1081896815580345 0.9516535659563489 1.03300927445368 1.5363486261015509 1.0670928280535794 1.2715526889594597 1.442492409259651 0.9857576007065362 1.0 10.895668116561195 DSAYISSSPLGS(ph)HQVFDFR ddPTM_A459_Selumetinib_30min_R2 1 DSAYISSSPLGSHQVFDFR 19 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 DSAY(0.001)IS(0.001)S(0.038)S(0.364)PLGS(0.597)HQVFDFR 72.48899999999998 0.012689 5866300.0 17268.0 17226.0 21637.0 26693.0 25692.0 13920.0 18557.0 20226.0 15639.0 16411.0 True False 16308.313689280956 18547.178809679954 20244.89897658436 23057.367352006637 22464.341270605815 15837.353646821151 19419.93726999791 20284.85431140544 18767.23699016972 15937.171789101283 1.0232878144937536 1.1637685189767193 1.2702943310449186 1.4467665691960814 1.4095563232849238 0.9937367718939697 1.2185309618911389 1.2728013840747667 1.1775763754396995 1.0 13.960108010894333 -6.755366156373824 24.999908693523093 1.1549543050177309 1.2678805237210646 0.17207789813583907 0.138270267626264 336.5648169217617 1385439.386427192 0.05011198588086533 0.04888830411993553 1.75644212226163e-07 6.755366156373824 0.11292621870333375 DSAYQSITHYRPVS(ph)ASR ddPTM_A459_Selumetinib_30min_R2 1 DSAYQSITHYRPVSASR 17 1 P50402;Q5HY57 P50402 EMD Emerin 1 DSAYQSIT(0.001)HY(0.134)RPVS(0.704)AS(0.16)R 68.48100000000001 0.015616 7110500.0 34191.0 11647.0 36442.0 49129.0 20430.0 21641.0 54603.0 35375.0 50291.0 29655.0 True False 32290.801097417494 12540.287448992363 34097.36139504957 42437.54544774785 17863.40075348267 24621.85131256155 57142.14769379184 35477.93539335349 60350.60524794585 28798.783097056763 1.1212557485013184 0.43544504664414035 1.1839861871988029 1.4735881479688275 0.6202831797885345 0.8549615179774004 1.9841861894376978 1.2319248099402968 2.0955956730725087 1.0 14.81372023090686 -7.244122357829747 24.65761542951384 1.5972537479447135 0.9446300544396825 0.3683547997228571 0.4036129597751187 712.6859809939358 1014791.0714301682 0.1498808812806867 0.11579798959348178 5.700036572162107e-08 7.244122357829747 -0.652623693505031 DSCIS(ph)PSEPETK ddPTM_A459_Selumetinib_30min_R1 2 DSCISPSEPETK 12 0 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 DS(0.005)CIS(0.878)PS(0.105)EPET(0.012)K;DS(0.287)CIS(0.709)PS(0.004)EPETK 114.87 0.005396 15015000.0 6017.7 6741.5 7648.2 8049.5 7011.8 6256.9 6857.1 6681.5 4084.7 5320.1 True False 6157.900701594131 5952.202045961679 6609.616448555398 6643.805932828878 6377.583928033832 6193.9612668106565 6339.863426317116 6504.284915429296 6931.43756531572 6002.98665716237 1.0258061617123415 0.9915401092654273 1.1010546626268505 1.1067500749650885 1.0624018163399576 1.0318132657217267 1.0561181938915034 1.0835081413464096 1.1546648295553987 1.0 12.551464745952389 -5.25736290567747 24.991480041261944 1.0760544447968892 1.008673131825948 0.29287430058283026 0.0408838286603167 426.3108779758745 2613545.6540422817 0.010576275151190615 0.025849367741520354 5.528879112698313e-06 5.25736290567747 -0.06738131297094108 DSCIS(ph)PSEPETK ddPTM_A459_Selumetinib_30min_R2 1 DSCISPSEPETK 12 0 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 DS(0.131)CIS(0.845)PS(0.022)EPET(0.002)K 117.27 0.004808 13341000.0 219180.0 189460.0 213450.0 213150.0 204450.0 160280.0 189450.0 194750.0 144080.0 200980.0 True False 206998.8530470579 203990.97279008315 199716.85938678816 184118.60229574115 178765.16319380963 182357.115123024 198259.80038805318 195316.69025740187 172900.0259315594 195177.18519124854 1.060568902273212 1.0451578784180038 1.0232592461618468 0.9433408014124632 0.9159121903445977 0.9343157344150521 1.0157939320304474 1.0007147611336675 0.885861868343575 1.0 17.574424896522437 -5.623571921817616 3.8257904437355763 0.9565247558768036 1.0496282928636007 0.5201693128423119 0.03860300623690939 0.18692934970653882 5.152759244005765 0.011231739836347902 0.02068705225625884 2.3791842608908064e-06 5.623571921817616 0.09310353698679708 DSDLSHVQNK ddPTM_A459_Selumetinib_30min_R1 1 DSDLSHVQNK 10 0 O60506-2;O60506;O60506-4;O60506-3;F6UXX1 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 104.42 0.018502 10486000.0 12533.0 14139.0 15339.0 16154.0 14760.0 13232.0 14627.0 13327.0 6175.8 10520.0 False True 12824.99451502721 12483.599306957236 13256.048051095855 13333.007148135623 13424.960606089646 13098.898093694746 13523.673613734736 12973.524667803074 10479.881537414445 11870.344473477582 1.080423111871997 1.051662766388109 1.1167365935095153 1.1232199013201454 1.1309663873770142 1.103497722661897 1.1392823219200805 1.0929358197473018 0.8828624612225948 1.0 13.535074181670533 -8.201575086946022 7.446577737569815 0.9420181117736643 1.10643741617732 0.769985769935498 0.035729409591702184 0.10879835425645504 12.022431079512412 0.024350415565506954 0.009038276523430902 6.286731508535764e-09 8.201575086946022 0.1644193044036557 DSDLSHVQNK ddPTM_A459_Selumetinib_30min_R2 2 DSDLSHVQNK 10 0 O60506-2;O60506;O60506-4;O60506-3;F6UXX1 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 ; 123.75 0.0056992 10574100.0 187694.0 169070.0 182960.0 228065.0 224958.0 168957.0 181485.0 179672.0 154684.0 188620.0 False True 177262.71887861367 182037.12535426658 171188.55279178574 197002.15356593102 196696.76488996332 192229.29311106048 189924.41210570527 180194.81577369926 185625.12223207424 183174.05050638455 0.9677283348191024 0.9937931975136493 0.9345677093372947 1.075491604958883 1.073824400051182 1.0494351824379202 1.0368521719133215 0.983735497880572 1.013381107852961 1.0 17.482855611837756 -5.757910454191711 24.999999957154657 1.0350836310075202 0.9682060937691909 0.5042228551110303 0.030769656452359937 82.4867267379314 584351.5902089485 0.009244399872837249 0.015223047809892216 1.7461821555918216e-06 5.757910454191711 -0.06687753723832934 DSDQVAQS(ph)DGEESPAAEEQLLGEHIK ddPTM_A459_Selumetinib_30min_R1 3 DSDQVAQSDGEESPAAEEQLLGEHIK 26 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H0Y8V7 D6REX3 SEC31A Protein transport protein Sec31A 1 DS(0.001)DQVAQS(0.999)DGEESPAAEEQLLGEHIK;DS(0.008)DQVAQS(0.981)DGEES(0.011)PAAEEQLLGEHIK;DSDQVAQS(0.999)DGEES(0.001)PAAEEQLLGEHIK 202.62 1.7835e-32 52238000.0 6670.4 9558.400000000001 4209.200000000001 3837.8799999999997 6081.6 6155.200000000001 8562.9 9293.5 5240.099999999999 9332.8 True False 6825.807341661016 8439.298084420394 3637.613759480581 3167.666303930096 5531.520353793689 6093.284276474448 7916.993558969658 9047.00619045756 8892.066978238521 10530.755789170304 0.6481782958712793 0.8013952895099192 0.34542760579648585 0.3008014208427171 0.5252728735274855 0.57861794523245 0.751797280031068 0.8591032183807156 0.8443901991709855 1.0 13.362321361417271 -7.453991835272596 1.5917970174844192 0.9093559513915134 0.5172696167752341 0.6025806634041946 0.13670677704147757 0.3153942828982589 1.5481529186627843 0.09805140344970405 0.050157427512782016 3.515670499195392e-08 7.453991835272596 -0.3920863346162793 DSDQVAQS(ph)DGEESPAAEEQLLGEHIK ddPTM_A459_Selumetinib_30min_R2 4 DSDQVAQSDGEESPAAEEQLLGEHIK 26 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H0Y8V7 D6REX3 SEC31A Protein transport protein Sec31A 1 DS(0.002)DQVAQS(0.998)DGEESPAAEEQLLGEHIK;DS(0.001)DQVAQS(0.999)DGEESPAAEEQLLGEHIK;DS(0.007)DQVAQS(0.874)DGEES(0.119)PAAEEQLLGEHIK;DS(0.001)DQVAQS(0.998)DGEESPAAEEQLLGEHIK 131.25 3.8153e-09 86393000.0 245850.0 175108.0 220619.0 273428.0 273395.0 243294.0 312233.0 324847.0 274748.0 206014.0 True False 232186.64121552717 188538.22053903653 206424.6137318048 236186.63471039152 239048.67591768954 276805.5400969618 326752.45317795203 325792.2509886842 329705.2771005271 200065.8405313453 1.1605511495559349 0.9423808684096538 1.0317834028216488 1.1805445351546007 1.1948500317835948 1.383572224832621 1.6332246040110885 1.6284251730501724 1.647983864836089 1.0 17.610115335318675 -6.6865916349246275 1.666093268881791 1.5297773463228472 1.0586765572897723 0.4757258912651193 0.18849613437008836 0.2720368685388962 1.5615322201062571 0.07519269134228748 0.07259377299578679 2.0578246494691579e-07 6.6865916349246275 -0.47110078903307495 DSDQVAQS(ph)DGEESPAAEEQLLGEHIKEEK ddPTM_A459_Selumetinib_30min_R1 4 DSDQVAQSDGEESPAAEEQLLGEHIKEEK 29 1 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H0Y8V7 D6REX3 SEC31A Protein transport protein Sec31A 1 DS(0.005)DQVAQS(0.992)DGEES(0.003)PAAEEQLLGEHIKEEK;DS(0.048)DQVAQS(0.926)DGEES(0.026)PAAEEQLLGEHIKEEK;DS(0.002)DQVAQS(0.998)DGEES(0.001)PAAEEQLLGEHIKEEK;DS(0.032)DQVAQS(0.968)DGEESPAAEEQLLGEHIKEEK 153.81 1.257e-16 52874200.0 12200.800000000001 12547.3 10004.9 7140.959999999999 11370.400000000001 9785.7 13230.099999999999 13781.1 7793.1 13117.0 True False 12485.054901375877 11078.256282918477 8646.28953298187 5893.925388420859 10341.94932760717 9687.264742704707 12232.142905385374 13415.580460678397 13224.321514496032 14800.694720399757 0.8435451941433371 0.7484956951141859 0.5841813304253017 0.3982195092705532 0.6987475603663988 0.6545141917799829 0.8264573478788022 0.9064155915727212 0.8934932963835127 1.0 13.853377274738317 -7.447487557012601 1.8049555465933962 0.9360069995225359 0.6410526704462469 0.5635911214267382 0.1114953042890535 0.3007336416303579 1.9126294230204324 0.0731719514553764 0.03889923576827527 3.5687197388924185e-08 7.447487557012601 -0.29495432907628893 DSDQVAQS(ph)DGEESPAAEEQLLGEHIKEEK ddPTM_A459_Selumetinib_30min_R2 3 DSDQVAQSDGEESPAAEEQLLGEHIKEEK 29 1 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;D6RHZ5;H0Y8V7 D6REX3 SEC31A Protein transport protein Sec31A 1 DS(0.004)DQVAQS(0.993)DGEES(0.004)PAAEEQLLGEHIKEEK;DS(0.009)DQVAQS(0.913)DGEES(0.078)PAAEEQLLGEHIKEEK;DS(0.005)DQVAQS(0.993)DGEES(0.001)PAAEEQLLGEHIKEEK 105.05 7.759899999999999e-11 49205200.0 321662.0 255394.0 320628.0 315341.0 297749.0 250182.0 258214.0 243320.0 170432.0 275554.0 True False 303785.3137550089 274981.8985788573 299999.14355337166 272391.01180643303 260343.10871016688 284642.2995739231 270221.46264133434 244028.0209162057 204523.1622679584 267598.0400447268 1.1352299654520404 1.0275930964699755 1.1210812437311921 1.0179110869455736 0.9728886977896126 1.06369351407188 1.0098035942123083 0.9119200606828751 0.7642924523429769 1.0 18.029708023793958 -7.744306854576379 2.971129088584798 0.8704399427938126 1.051481115382924 0.5259124384431302 0.06959861101069208 0.18968369254494755 3.3988486929867787 0.04023441464314538 0.018851034596842772 1.8017442528064285e-08 7.744306854576379 0.18104117258911134 DSDSGVGS(ph)DNGDKR ddPTM_A459_Selumetinib_30min_R1 2 DSDSGVGSDNGDKR 14 1 Q9Y2L9-2;Q9Y2L9;Q9Y2L9-3;C9J5B8 Q9Y2L9-2 LRCH1 Leucine-rich repeat and calponin homology domain-containing protein 1 1 DSDSGVGS(1)DNGDKR;DSDSGVGS(1)DNGDKR 176.19 0.00012393 1665200.0 768.03 959.78 1163.03 826.48 587.85 786.77 731.12 792.5999999999999 729.25 821.3900000000001 True False 785.9236046737688 847.4085114103837 1005.0969140664978 682.1507829510425 534.679071293347 778.8558081300039 675.9710297719106 771.577673272358 1237.4839876873418 926.8234075161367 0.8479755671903282 0.914314965006567 1.0844535279489025 0.7360094462646226 0.5768942248947654 0.840349738487203 0.7293417756716954 0.8324969643787554 1.335188535002334 1.0 9.856150670620755 -8.23859425018622 21.89316316409228 1.1675939469850392 0.8188955892044919 0.4780806062080397 0.14517132905995525 125.00693676572982 119799.04833478831 0.10321322133352225 0.038899684429688317 5.77305572797533e-09 8.23859425018622 -0.34869835778054725 DSEAFCHR ddPTM_A459_Selumetinib_30min_R2 2 DSEAFCHR 8 0 C9JP16;O75718 C9JP16 CRTAP Cartilage-associated protein 0 ; 139.97 0.0012695 1187400.0 41457.0 39539.0 47414.0 49996.0 54808.0 37346.0 32345.0 43972.0 41483.0 47736.0 False True 39152.98590552005 42571.514162076855 44363.43486045994 43186.45855208942 47922.52905026325 42490.072506766024 33849.10659040161 44099.95124004352 49780.75913186334 46357.73764697694 0.8445836206175018 0.9183259650474556 0.9569801528775198 0.9315911591925081 1.0337546973323526 0.9165691568112334 0.7301716673097606 0.951296449707557 1.0738392695293582 1.0 15.500522541124033 -8.010335501102674 24.83740601407245 1.028802416276266 0.9083792403084712 0.3219219739231356 0.07581001033527496 588.513304534063 1414257.9424297484 0.04848723975819423 0.020972487897951482 9.764825773425952e-09 8.010335501102674 -0.12042317596779473 DSEEEAAS(ph)PEGK ddPTM_A459_Selumetinib_30min_R1 1 DSEEEAASPEGK 12 0 A0A3B3ITU7;Q9HB96 A0A3B3ITU7 FANCE Fanconi anemia group E protein 1 DSEEEAAS(1)PEGK 167.73 1.737e-05 0.0 1677.3 1827.8 1767.9 1674.9 1462.6 1660.9 1647.3 1263.1 957.31 1371.9 True False 1716.3778265423387 1613.8003262788334 1527.828890379579 1382.4101567668913 1330.308088243003 1644.1928539765406 1523.0428347511609 1229.5984848729693 1624.4851508439756 1547.9967284376328 1.108773549072452 1.042508873973923 0.9869716533067813 0.893031704377137 0.8593739662393607 1.0621423312929072 0.983879879570768 0.7943159454309586 1.0494112300117981 1.0 10.596186707131626 -5.158067827859479 2.075214175516953 0.9431730458500179 1.105452022358056 0.2930118644630225 0.07935598407133934 0.47078117882473414 3.5184747226259074 0.02199030542214638 0.10601797271590296 6.949157775713718e-06 5.158067827859479 0.16227897650803802 DSEGDSLGARPGLPYGLS(ph)DDESGGGR ddPTM_A459_Selumetinib_30min_R1 2 DSEGDSLGARPGLPYGLSDDESGGGR 26 1 Q8N8E2;Q8N8E2-2;C9JT52 Q8N8E2 ZNF513 Zinc finger protein 513 1 DSEGDSLGARPGLPYGLS(0.987)DDES(0.013)GGGR;DSEGDS(0.006)LGARPGLPY(0.296)GLS(0.52)DDES(0.178)GGGR 116.65 4.277399999999999e-09 12483600.0 1024.12 1140.2 945.02 1085.6399999999999 1132.48 982.5699999999999 915.56 1019.31 630.5699999999999 891.46 True False 1047.9800034093723 1006.7048539354013 816.691474623287 896.0533539867506 1030.0473839555834 972.6862379021794 846.4985720784147 992.2745876144932 1070.031234989383 1005.8875745557351 1.041846057072758 1.0008124957503597 0.8119112863920113 0.8908086516353536 1.024018399283358 0.9669929945518817 0.8415439195103718 0.9864666914219968 1.0637682202824483 1.0 9.974253352534488 -7.997888513453627 24.99637625152988 1.0296285793726225 0.9377269929708073 0.20832363826439115 0.0724215023424553 100.51685901754715 1189952.6327992363 0.04215632627833887 0.02004383571638294 1.0048737155492457e-08 7.997888513453627 -0.09190158640181523 DSEGDSLGARPGLPYGLS(ph)DDESGGGR ddPTM_A459_Selumetinib_30min_R2 2 DSEGDSLGARPGLPYGLSDDESGGGR 26 1 Q8N8E2;Q8N8E2-2;C9JT52 Q8N8E2 ZNF513 Zinc finger protein 513 1 DSEGDSLGARPGLPY(0.003)GLS(0.974)DDES(0.024)GGGR;DSEGDSLGARPGLPY(0.254)GLS(0.74)DDES(0.005)GGGR 82.76100000000002 6.4163e-05 6784800.0 12908.6 12384.3 12975.0 15647.0 16439.5 13203.8 10884.7 11533.900000000001 14206.5 12603.9 True False 12191.191689220064 13334.135988199203 12140.202626111852 13515.851607419467 14374.22303900531 15022.503597837436 11390.860117623875 11567.461739460063 17048.196962775513 12239.99265813501 0.9960129903441967 1.0893908485588017 0.991847214715702 1.104236904785763 1.1743653317840708 1.227329461497111 0.9306263848167605 0.9450546305493112 1.392827384699847 1.0 13.579315072214378 -5.823670642509081 9.708798780107664 1.1084946543708631 1.0321986892360588 0.07856767686771426 0.13253319097484187 1.1294075098806564 167.35273138034347 0.03772291724533864 0.056088879528298476 1.500822588329558e-06 5.823670642509081 -0.0762959651348043 DSEGFNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DSEGFNSPK 9 0 O43303-2;O43303;I3L262 O43303-2 CCP110 Centriolar coiled-coil protein of 110 kDa 1 DSEGFNS(1)PK 101.71 0.016779 8156900.0 3846.9 4536.8 4120.8 5023.6 3868.1 3889.4 3824.7 4088.9 2815.3 3952.9 True False 3936.5252852356316 4005.6293468988997 3561.2179939341386 4146.3225646511155 3518.2310379685205 3850.2761672926463 3536.1997997163635 3980.449089380955 4777.358478623486 4460.29321950661 0.8825709637249104 0.8980641293672608 0.7984268788337809 0.9296076200814831 0.7887891815232949 0.8632338677766476 0.7928177870125616 0.8924187028720201 1.071086191762063 1.0 12.1229228406424 -8.146010159836859 4.588501622485054 1.0335728892696903 0.8510624690170338 0.7017738116711225 0.047403371423871084 0.11347118623549804 3.657413014596456 0.033005890171884135 0.011612749838797032 7.144796114233539e-09 8.146010159836859 -0.1825104202526565 DSEGFNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 DSEGFNSPK 9 0 O43303-2;O43303;I3L262 O43303-2 CCP110 Centriolar coiled-coil protein of 110 kDa 1 DSEGFNS(1)PK 100.88 0.017523 1762900.0 31145.0 25596.0 28721.0 24895.0 27742.0 21418.0 25610.0 24251.0 18596.0 28375.0 True False 29414.08558331339 27559.130895888105 26873.12212906039 21504.258053729623 24256.8019433733 24368.135086753973 26800.91574525226 24321.566395030815 22315.719615652924 27555.740022896167 1.0674395083882022 1.0001230550509304 0.9752277422682684 0.7803912373923421 0.8802812743630993 0.8843215630030766 0.9726073668492764 0.882631581471662 0.8098392421002197 1.0 14.750065251522136 -5.53469199495952 24.022283713628934 0.8848337203535214 1.0222548433605645 0.47271817115850845 0.06329075406078122 112.60273219473801 228976.97003417797 0.017184724414846458 0.029801180556057228 2.9194968099095e-06 5.53469199495952 0.13742112300704312 DSENLAS(ph)PSEYPENGER ddPTM_A459_Selumetinib_30min_R1 2 DSENLASPSEYPENGER 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 DSENLAS(0.994)PS(0.006)EYPENGER;DSENLAS(0.881)PS(0.119)EYPENGER 323.2 8.160999999999996e-119 131632700.0 3164.6000000000004 3770.3 3661.0 3747.3 3771.6 3452.7 4405.4 4507.6 3013.1 3001.4 True False 3238.3290227603215 3328.8715232350833 3163.85630843353 3092.904400532911 3430.4594459300615 3417.968972800773 4073.0971311921116 4388.043805251684 5113.010631883071 3386.658926111751 0.9562017000862475 0.9829367514894646 0.9342116751231213 0.9132612607328303 1.0129332539160056 1.0092451136568894 1.2026889096471447 1.2956851873742214 1.509750684505262 1.0 11.725646983515256 -7.31363757254132 2.0590405192000483 1.3014014697380187 0.957595960771152 0.582047886128182 0.11849290391200452 0.21208544162025866 1.755015796026457 0.05849240166723865 0.035933267718761173 4.856936521823958e-08 7.31363757254132 -0.3438055089668667 DSENLASPS(ph)EYPENGER ddPTM_A459_Selumetinib_30min_R1 2 DSENLASPSEYPENGER 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 DSENLAS(0.079)PS(0.921)EYPENGER;DSENLAS(0.001)PS(0.999)EYPENGER 263.47 1.6019999999999997e-40 139236200.0 4244.4 4586.2 5459.9 5532.6 5476.0 4668.4 5942.6 6171.1 3722.1000000000004 3575.3999999999996 True False 4343.286261835274 4049.245571933463 4718.475569083919 4566.435269764466 4980.696766866326 4621.440134568058 5494.344897585294 6007.422381442154 6316.131848571903 4034.337417345227 1.076579822788682 1.0036953167387883 1.1695788133132616 1.1318922532685387 1.2345761525677852 1.1455264288749478 1.3618952331460705 1.489072866244119 1.565593354045284 1.0 11.9781160354383 -7.269171344588146 3.2117595515361876 1.401929495296433 1.1244835654077132 0.33914305924229793 0.1507200816404792 0.25004985810516417 5.35656519131152 0.06467818700037692 0.04422329235930892 5.380574578690659e-08 7.269171344588146 -0.27744592988871974 DSENLASPS(ph)EYPENGER ddPTM_A459_Selumetinib_30min_R2 4 DSENLASPSEYPENGER 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 DSENLAS(0.001)PS(0.999)EYPENGER;DSENLAS(0.079)PS(0.921)EYPENGER;DSENLAS(0.087)PS(0.913)EYPENGER;DSENLAS(0.015)PS(0.985)EYPENGER 285.34 2.392399999999999e-64 491831500.0 154249.0 150287.4 188031.0 167183.0 177317.0 128541.5 145765.0 163147.0 171829.0 236779.0 True False 145676.4580876708 161813.96032984398 175933.29017267373 144412.3869932388 155040.8532259075 146246.92484144116 152543.36132786793 163621.73075956016 206199.60130340006 229942.57504427532 0.6335340815402318 0.7037146570124597 0.7651183785290648 0.6280367477203048 0.674259010955472 0.636014991191959 0.6633976387299994 0.711576491339435 0.8967438990526067 1.0 17.810914087593893 -8.356691142635949 2.309350532606749 0.9979717609930882 0.6735007399608678 0.8946213768969764 0.03827636400909384 0.08650631468652435 0.8931463851567939 0.03793633696575425 0.010634615496537145 4.3985431558609206e-09 8.356691142635949 -0.32447102103222036 DSENT(ph)PVKGGTVADLDEQDEETVTAGGK ddPTM_A459_Selumetinib_30min_R2 2 DSENTPVKGGTVADLDEQDEETVTAGGK 28 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 DS(0.087)ENT(0.899)PVKGGT(0.014)VADLDEQDEETVTAGGK;DS(0.032)ENT(0.808)PVKGGT(0.16)VADLDEQDEETVTAGGK 114.91 5.9146e-12 16747700.0 96738.0 80309.0 84665.0 96465.0 99684.0 85058.0 100921.0 103465.0 79462.0 86212.0 True False 91361.68923289671 86468.44206586473 79217.74607628222 83326.30058859318 87160.80473373304 96773.96742035294 105614.02647116761 103766.06602044721 95356.62035378645 83722.83555432326 1.0912397869469794 1.0327939981172758 0.946190433610936 0.9952637179199122 1.0410636973371388 1.1558849718791655 1.261472163142878 1.239399804526675 1.138955933855282 1.0 16.353333553671554 -6.756081485328158 3.599810701469648 1.1833675461782267 1.013372972372831 0.4476766000564836 0.07501563902490502 0.1821794854411615 5.036864909657891 0.026557134959019322 0.024863326782123857 1.7535514575466183e-07 6.756081485328158 -0.16999457380539562 DSENT(ph)PVKGGTVADLDEQDEETVTAGGKEDEDPAK ddPTM_A459_Selumetinib_30min_R2 1 DSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAK 35 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 DS(0.014)ENT(0.843)PVKGGT(0.143)VADLDEQDEETVTAGGKEDEDPAK 61.738 0.00036397 5924300.0 29161.0 27750.0 27960.0 24598.0 20164.0 21365.0 28953.0 21483.0 16469.0 26776.0 True False 27540.348360732092 29878.335769686444 26161.08404054625 21247.709966083192 17630.818051552847 24307.83481784008 30299.371869281113 21545.511973297896 19763.260182307382 26002.907307597103 1.0591257367858171 1.1490382754607245 1.0060830402953802 0.8171282431897676 0.67803256931973 0.9348121935095395 1.1652301610300606 0.8285808859151331 0.7600404042717668 1.0 14.666385315255663 -5.547102910439313 4.733856724860585 0.8822497782678491 1.1001989432162098 0.32771136469712436 0.12837480543062885 0.2281266139089484 12.885168429080371 0.037960850329556456 0.07118453865355796 2.8372466346935685e-06 5.547102910439313 0.2179491649483607 DSFDDRGPSLNPVLDYDHGS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 DSFDDRGPSLNPVLDYDHGSR 21 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 DSFDDRGPSLNPVLDYDHGS(1)R;DSFDDRGPSLNPVLDYDHGS(1)R 91.202 0.00029121 11944200.0 3690.3999999999996 4617.700000000001 5581.1 5046.0 4896.1 3348.5 4833.4 4716.9 2501.31 3087.8 True False 3776.3791397316204 4077.057537289511 4823.217274787868 4164.810825151192 4453.248619476662 3314.817130194742 4468.812746607333 4591.792489349468 4244.540381545732 3484.1492077190196 1.0838741151972409 1.1701730592527215 1.3843314356636007 1.195359491471889 1.2781452096284034 0.9513993036953963 1.2826123337963895 1.317909255773691 1.2182429995081985 1.0 11.766590692934965 DSFDDRGPSLNPVLDYDHGS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 DSFDDRGPSLNPVLDYDHGSR 21 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 DSFDDRGPSLNPVLDYDHGS(1)R;DSFDDRGPSLNPVLDYDHGS(1)R 94.072 0.00020116 5572800.0 28004.0 30045.0 30137.0 31432.0 28737.0 26585.0 23533.2 22289.4 18917.1 25379.0 True False 26447.64978889414 32349.35489009838 28198.01823068463 27150.907376775634 25126.80114796042 30246.84243539802 24627.54043015116 22354.25846379118 22701.048587936537 24646.24232743898 1.0730905522035556 1.3125471404654423 1.1441102402572505 1.101624621557347 1.0194982591722077 1.2272395131700795 0.9992411866669427 0.9070047338982744 0.9210754437264932 1.0 14.58908008340148 -7.444565366868378 4.926158184581922 0.9378482468467191 1.1453984098095478 0.583672485241638 0.07935482664508503 0.15724309633140038 6.8126125520159695 0.03563716819597762 0.023171554472923975 3.5928131625706144e-08 7.444565366868378 0.2075501629628287 DSFDDRGPSLNPVLDYDHGSR ddPTM_A459_Selumetinib_30min_R1 2 DSFDDRGPSLNPVLDYDHGSR 21 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 0 ; 125.51 5.4662e-05 27126000.0 5695.3 5708.3 5386.700000000001 6454.6 11418.4 5906.6 10350.2 5436.299999999999 1724.7 3164.2 False True 5827.989408875325 5039.969582283325 4655.2157270251 5327.42527784798 10385.607736082255 5847.184966763706 9569.476081006178 5292.111664408933 2926.6899328959316 3570.3558919180405 1.632327304420192 1.4116154621145593 1.3038520158628386 1.4921272386059026 2.9088438381146857 1.6377036754233831 2.6802583189726037 1.4822364561438564 0.8197193841434325 1.0 11.801852173458327 -8.004553755799826 24.867627947474286 0.9902321995506448 1.8613150211452814 0.3606106965755447 0.5048649819859978 205.6989558632108 1123295.019597038 0.30278261968585474 0.13948911484102888 9.895693700601876e-09 8.004553755799826 0.8710828215946366 DSFDDRGPSLNPVLDYDHGSR ddPTM_A459_Selumetinib_30min_R2 4 DSFDDRGPSLNPVLDYDHGSR 21 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 0 ;;; 124.45 5.6743e-05 23380000.0 46765.2 52915.4 87725.5 133706.0 155256.0 100223.0 61290.9 70057.0 83734.7 117739.0 False True 44166.1773999283 56973.84103017181 82081.33683830261 115495.01214428477 135751.35327374976 114027.80851618951 64141.04829561429 70260.85427143924 100483.97974299919 114339.56914733982 0.3862720292658708 0.4982863015405839 0.7178734138181968 1.010105364272066 1.1872648662758067 0.997273379342994 0.560969826753161 0.6144929073582563 0.8788206960401775 1.0 16.80296523348941 -5.331503589614083 2.6678342241560244 0.8785036129385619 0.41706656321227137 0.4998142920554668 0.1785735519120967 0.27497397796595363 3.759320172578552 0.05671584749395676 0.16038898147775538 4.661185753332785e-06 5.331503589614083 -0.46143704972629057 DSFIENSSSNCTSGS(ph)SKPNS(ph)PSISPSILSNTEHK ddPTM_A459_Selumetinib_30min_R2 1 DSFIENSSSNCTSGSSKPNSPSISPSILSNTEHK 34 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 2 DS(0.006)FIENS(0.212)S(0.183)S(0.183)NCT(0.146)S(0.131)GS(0.185)S(0.185)KPNS(0.328)PS(0.271)IS(0.105)PS(0.05)ILS(0.007)NT(0.007)EHK 42.31399999999999 0.029652 6876000.0 6346.4 7332.0 6579.9 9442.0 9107.6 5041.4 4559.3 5689.8 5244.9 7249.1 True False 5993.692494652112 7894.340823904187 6156.556397653438 8155.983311641499 7963.421865022948 5735.807088727308 4771.316484081558 5706.356376002902 6294.026554750381 7039.799647576264 0.8514010049583846 1.121387144394391 0.8745357404841886 1.1585533282114822 1.1312000715481552 0.814768512723525 0.6777631073242655 0.8105850537902093 0.89406330717343 1.0 12.781318655064254 -6.7784750146596275 24.945833927594677 0.8174929274005716 1.031428217240574 0.36403396151822254 0.1224680821926229 233.04821051051562 341257.842820394 0.04255261650954128 0.0376199021396345 1.665424638361134e-07 6.7784750146596275 0.21393528984000243 DSFSHS(ph)PGAVSSLK ddPTM_A459_Selumetinib_30min_R2 1 DSFSHSPGAVSSLK 14 0 Q9H6R7;Q9H6R7-3 Q9H6R7 C2orf44 WD repeat and coiled-coil-containing protein C2orf44 1 DSFS(0.004)HS(0.996)PGAVSSLK 107.63 0.0034013000000000003 23772000.0 131750.0 107740.0 170840.0 193630.0 237430.0 151440.0 133870.0 139720.0 175860.0 210040.0 True False 124427.86243703758 116003.31156129824 159848.34039652787 167257.2599696189 207601.92074886904 172299.48536455422 140095.22025837252 140126.56206810888 211036.91393895057 203975.59945054093 0.6100134661803422 0.5687117080365595 0.7836640305365895 0.819986608301032 1.0177782112571137 0.844706356194985 0.6868234270949755 0.6869770817959338 1.034618427436571 1.0 17.638037054784732 -5.393448768747818 2.841393653739083 0.8535171826637026 0.5850223027026543 0.46294239120659286 0.11817327779913231 0.26129202156693104 4.001198059268773 0.03385078056994405 0.08532461392455311 4.041580479298687e-06 5.393448768747818 -0.26849487996104826 DSGFSSGNTDTSS(ph)ER ddPTM_A459_Selumetinib_30min_R2 2 DSGFSSGNTDTSSER 15 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 DSGFSSGNTDT(0.003)S(0.051)S(0.945)ER;DSGFSSGNTDTS(0.179)S(0.821)ER 160.03 7.5214e-05 2977500.0 32874.0 24980.8 33320.0 37153.0 39580.0 33404.0 36489.0 40329.0 25591.5 27436.9 True False 31046.994685048776 26896.747034067874 31176.22747607299 32092.697307500166 34607.60655031054 38005.09778867913 38185.81080158181 40446.35071317466 30710.51508625414 26644.72540737266 1.165221041326926 1.0094585935055453 1.1700712617382218 1.204467181283844 1.2988539390514615 1.4263647760529379 1.4331470945095834 1.5179871473542397 1.1525926657797894 1.0 14.701562344737356 -6.001579188765362 1.723785687906813 1.34593788622653 1.0939040445165116 0.2327592705402548 0.14731773279600432 0.411628594787391 2.463954390789461 0.04759177836700522 0.07889288777972481 9.963703865193352e-07 6.001579188765362 -0.2520338417100185 DSGLES(ph)PAAAEAPLR ddPTM_A459_Selumetinib_30min_R1 1 DSGLESPAAAEAPLR 15 0 H0YM15;J3KNL7;Q8NBR6-2;Q8NBR6 H0YM15 FAM63B Protein FAM63B 1 DS(0.027)GLES(0.973)PAAAEAPLR 139.21 0.00039448 2241600.0 688.01 949.46 803.94 1111.0 758.45 726.91 981.64 817.31 375.1 720.91 True False 704.0392943655847 838.2967818080207 694.7693637263188 916.9847060529085 689.8483314152236 719.5979453814723 907.5941044771024 795.6322838029668 636.5173037799414 813.4458207580541 0.8655023806127459 1.0305502350811857 0.8541065010068647 1.1272843041941822 0.8480568881309767 0.884629224243694 1.115740079199511 0.9781011390058076 0.7824950199962523 1.0 9.667902448731333 DSGLES(ph)PAAAEAPLR ddPTM_A459_Selumetinib_30min_R2 1 DSGLESPAAAEAPLR 15 0 H0YM15;J3KNL7;Q8NBR6-2;Q8NBR6 H0YM15 FAM63B Protein FAM63B 1 DSGLES(1)PAAAEAPLR 161.94 0.00011605 2238600.0 8081.3 10262.0 11289.0 11603.0 12335.0 9653.1 10387.0 9130.2 9007.5 9924.5 True False 7632.173698007072 11049.06240246928 10562.678030533856 10022.65138370857 10785.367023700874 10982.726902882854 10870.016081450038 9156.76737041402 10809.251690578283 9637.953898052258 0.7918873423486145 1.146411626299872 1.0959461045635916 1.0399148501565312 1.1190515266814565 1.1395288895397562 1.1278344134481457 0.950073788199435 1.1215297152191954 1.0 13.2345111848051 -4.753924564855263 24.999809529945257 1.084163200499509 0.7918868248592138 0.6626099903673137 0.06214583365045938 162.4206699737816 540286.1209923989 0.015298276564391923 0.15677333589275136 1.7622821209018113e-05 4.753924564855263 -0.2922763756402952 DSGNWDTSGSELS(ph)EGELEKR ddPTM_A459_Selumetinib_30min_R1 1 DSGNWDTSGSELSEGELEKR 20 1 O75400-3;O75400;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 DSGNWDTSGS(0.001)ELS(0.999)EGELEKR 131.78 7.7925e-05 8926500.0 1512.1 1564.9 2126.8 2301.2 1882.0 1771.9 2180.5 1553.4 1088.6 1611.4 True False 1547.3289879655824 1381.6807804977268 1837.9922416761622 1899.3386188739455 1711.7734322940864 1754.0762947564776 2016.0231294693785 1512.198785845675 1847.274691801771 1818.2388863651888 0.8510042324849966 0.7599005778937122 1.0108640044270871 1.0446034528889006 0.9414458381296994 0.9647116822273131 1.108777919440265 0.8316832277570999 1.0159691917571003 1.0 10.828326042793341 -5.265669863577109 24.982493750797953 0.9873352918040512 0.8054523995020463 0.5178577315397072 0.07110346626072508 249.46910744696672 1473211.2652637847 0.018041542375409735 0.039825296443386046 5.424130583425596e-06 5.265669863577109 -0.18188289230200494 DSGNWDTSGSELS(ph)EGELEKR ddPTM_A459_Selumetinib_30min_R2 2 DSGNWDTSGSELSEGELEKR 20 1 O75400-3;O75400;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 DSGNWDTSGS(0.004)ELS(0.996)EGELEKR;DSGNWDTSGSELS(1)EGELEKR 177.49 2.0231e-13 16675700.0 28087.0 24546.0 22554.0 28464.0 21821.1 20269.2 21428.0 20697.1 16281.7 23860.0 True False 26526.036981169447 26428.59927217024 21102.900194938473 24587.154096861217 19079.738334890873 23061.098314522067 22424.44445877649 20757.32513441065 19538.494948708136 23171.099804274978 1.144789725357598 1.140584585773277 0.9107422769395292 1.0611129512430386 0.8234282574438152 0.9952526427022417 0.9677764391071012 0.8958282217825934 0.8432269125655986 1.0 14.500038902151724 -5.256499335856747 24.37953053119252 0.936982198312997 1.142687197176552 0.5857174085828851 0.06913681800220765 190.65174510612025 940870.4951762948 0.01734027649014418 0.04290113636893642 5.53988391122674e-06 5.256499335856747 0.20570499886355498 DSGRGDS(ph)VSDSGSDALR ddPTM_A459_Selumetinib_30min_R1 2 DSGRGDSVSDSGSDALR 17 1 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 1 DS(0.002)GRGDS(0.82)VS(0.177)DS(0.001)GSDALR;DS(0.001)GRGDS(0.905)VS(0.093)DS(0.001)GSDALR 120.99 0.006564199999999999 64148000.0 5209.5 6471.2 7370.5 7968.1 7249.799999999999 5951.200000000001 8452.5 7772.9 3985.7 6274.8 True False 5330.871214077576 5713.548895620741 6369.62658325849 6576.62091476164 6594.056870056145 5891.336331257264 7814.921119853207 7566.737442062466 6763.441795989636 7080.231701727871 0.75292327125066 0.8069720224306215 0.8996353299714805 0.9288708607031421 0.9313334856607759 0.8320824203845664 1.1037662959456596 1.0687132513214033 0.9552571272969888 1.0 12.789580858171504 -4.1354008695047 0.3429059967130504 1.0320847885232662 0.3844359736225317 0.6229791630103472 0.06496356623845663 7.166483279918812 0.480452423438486 0.06505759905622828 2.093398220479234 7.321484216919742e-05 4.1354008695047 -0.6476488149007346 DSGRLS(ph)PDLSVCGQPR ddPTM_A459_Selumetinib_30min_R1 1 DSGRLSPDLSVCGQPR 16 1 Q8TF76-2;Q8TF76 Q8TF76-2 GSG2 Serine/threonine-protein kinase haspin 1 DS(0.172)GRLS(0.828)PDLSVCGQPR 132.15 0.0030517 15792000.0 3464.9 4606.4 3721.3 4230.3 3581.8 3228.6 3496.5 3162.1 1995.9 2898.1 True False 3545.6254284782403 4067.0805465427375 3215.9678996377206 3491.5575175658114 3257.8268224181516 3196.123215334253 3232.7561899517013 3078.2308360516327 3386.89652523163 3270.0993648845447 1.0842561747671613 1.2437177262001429 0.9834465380996962 1.0677221478525578 0.996247042949771 0.9773780117067166 0.9885804158326663 0.9413263918236667 1.0357167007220924 1.0 11.675118758626482 -5.275890607088951 24.954208293331906 0.9979466274766656 1.1639869504567477 0.6554814144327634 0.04789906482071401 375.6306284325002 648634.5937231453 0.01203098366352222 0.02522446599138665 5.29796875759577e-06 5.275890607088951 0.1660403229800821 DSGRLS(ph)PDLSVCGQPR ddPTM_A459_Selumetinib_30min_R2 1 DSGRLSPDLSVCGQPR 16 1 Q8TF76-2;Q8TF76 Q8TF76-2 GSG2 Serine/threonine-protein kinase haspin 1 DS(0.038)GRLS(0.962)PDLSVCGQPR 95.195 0.0048536 13204000.0 17091.0 20817.0 23558.0 19378.0 20847.0 11044.0 14223.0 15359.0 13031.0 25071.0 True False 16141.150640693815 22413.59696279507 22042.30392801102 16738.682971085454 18228.01348545536 12565.210752549763 14884.39768233983 15403.69214718067 15637.564116561265 24347.13508771911 0.6629589305903815 0.9205845731763597 0.9053346050200927 0.6875011335328969 0.7486718014165747 0.5160858025915236 0.6113408262907959 0.6326695971285105 0.6422753256274895 1.0 14.571464400813703 -5.854472240309584 6.284187099397611 0.6659923351188095 0.838020864513594 0.16026118420332935 0.13701131896461355 0.2900261170391063 16.163501507644543 0.03732791577519683 0.056062284851273264 1.3980662755340828e-06 5.854472240309584 0.17202852939478452 DSGS(ph)DGEDDVNEQHSGSDTGSVER ddPTM_A459_Selumetinib_30min_R2 1 DSGSDGEDDVNEQHSGSDTGSVER 24 0 Q96ST2;Q96ST2-3;B8ZZB6 Q96ST2 IWS1 Protein IWS1 homolog 1 DS(0.078)GS(0.922)DGEDDVNEQHSGSDTGSVER 100.86 3.3112e-06 3014200.0 5217.8 3562.4 5748.2 5332.3 6133.3 5247.6 7568.5 8321.7 6664.5 10082.0 True False 4927.815564508349 3835.624625078595 5378.367070166946 4606.031541269429 5362.780021602315 5970.409267030079 7920.450246698235 8345.914769268406 7997.586221688475 9790.906463818117 0.5033053459063146 0.3917537808427631 0.5493226893794232 0.47043974511357295 0.5477306969911564 0.6097912679580256 0.8089598522841501 0.8524149219595124 0.8168381805344805 1.0 13.257226718578497 -7.2944694886434265 0.7392916205880503 0.9523907596359855 0.4531891137379102 0.924529008733472 0.05205077668515669 0.16573766875878096 0.1774734704757522 0.04299331990625708 0.026590861182517612 5.0761039994222335e-08 7.2944694886434265 -0.4992016458980753 DSGS(ph)DQDLDGAGVR ddPTM_A459_Selumetinib_30min_R2 2 DSGSDQDLDGAGVR 14 0 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 DS(0.005)GS(0.995)DQDLDGAGVR;DS(0.002)GS(0.998)DQDLDGAGVR 195.5 0.00012508 25930000.0 68976.0 68832.0 79211.0 65788.0 69267.0 55530.0 73790.0 71315.0 61570.0 60373.0 True False 65142.590052805346 74111.19307023619 74114.65049841578 56827.56090936999 60565.06020516324 63178.753448849064 77221.38121211104 71522.51484316618 73885.72040953703 58629.87462210783 1.1110818583985465 1.2640517065388837 1.2641106769563009 0.9692594650021947 1.033006817693683 1.0775863645634671 1.3170995454080814 1.2198988195720422 1.260206010771113 1.0 15.839348351135333 -7.2385341076206124 24.838098822182467 1.2176260223965045 1.1221690614614523 0.09398065017301471 0.11523636609539488 1597.519834743741 1732326.4685988838 0.046242803574152516 0.03579449706839638 5.773855255576086e-08 7.2385341076206124 -0.09545696093505218 DSGS(ph)ISLQETR ddPTM_A459_Selumetinib_30min_R1 3 DSGSISLQETR 11 0 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 DS(0.001)GS(0.996)IS(0.004)LQETR;DSGS(0.957)IS(0.042)LQETR;DSGS(0.999)IS(0.001)LQETR 203.88 1.7902e-05 120927000.0 6133.4 7928.5 5626.9 6514.9 7259.9 5863.4 7393.0 5867.799999999999 2993.83 4878.67 True False 6276.296286481116 7000.227534140348 4862.797886349255 5377.195014819164 6603.243326839447 5804.419519541242 6835.340057861555 5712.1668826994 5080.310849308191 5504.894816770049 1.140130101552727 1.2716369280689859 0.8833589102438948 0.9768024991936517 1.199522161027201 1.0544106132343753 1.2416840439963452 1.037652320857779 0.9228715567519273 1.0 12.426499282825217 -7.266951197272019 0.015338585490836562 7.596893629690481e-05 2.1402093676168157 0.09201563139786084 0.12169507923439284 2016.8058203885334 18.60524868489306 1265.0076060031665 1326.7128332424556 5.4081509223935023e-08 7.266951197272019 2.140133398680519 DSGS(ph)ISLQETR ddPTM_A459_Selumetinib_30min_R2 3 DSGSISLQETR 11 0 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 DS(0.08)GS(0.913)IS(0.007)LQETR;DS(0.01)GS(0.99)ISLQETR;DSGS(0.874)IS(0.126)LQETR 154.23 0.00054657 95053000.0 161774.0 126453.0 202763.0 209968.0 239778.0 198311.0 206977.0 173624.0 175977.0 165718.0 True False 152783.2487126324 136151.53848951956 189717.4493316624 181369.9961849969 209654.94399748268 225626.54016197936 216601.8406171448 174129.21709499936 211177.3172082037 160933.2907529274 0.949357637551777 0.8460122691366948 1.1788577021203517 1.126988675472031 1.3027444043218823 1.4019879858690778 1.345910716196579 1.0819962500010702 1.3122040580927 1.0 17.296103268094328 -5.421753214159868 2.0344436467125235 1.247604723842636 0.886595361037706 0.5049305020171972 0.12437430108118146 0.2644223932961669 2.0780940640888694 0.035664181168242125 0.10598801610217579 3.786576940854207e-06 5.421753214159868 -0.36100936280493 DSGS(ph)QEVLSELR ddPTM_A459_Selumetinib_30min_R1 2 DSGSQEVLSELR 12 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2;X6RJY0 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 DS(0.401)GS(0.599)QEVLSELR;DS(0.088)GS(0.912)QEVLSELR 127.05 0.0026482 26554000.0 2542.8 3615.3 2951.6000000000004 3158.0 3305.7 2675.3 2849.5 3154.0 1504.56 2746.3 True False 2602.0422925725043 3192.0189952926303 2550.788931978259 2606.5145830018773 3006.7000186687383 2648.38891097805 2634.559920854387 3070.345674364142 2553.1284312853877 3098.8143562273276 0.8396896339864574 1.0300775162210025 0.8231499660030406 0.8411328603031245 0.9702743285110068 0.8546458763029446 0.8501832049280454 0.9908130405404971 0.823904931947492 1.0 11.597500613199463 -11.592953894231101 2.754727992935329 1.1636805280117433 0.8950556137742095 0.1652689667174574 0.07273969399073309 64499396.374158606 49647863.21535845 65672050.38397809 0.017032483539136677 2.552972318086976e-12 11.592953894231101 -0.26862491423753376 DSGS(ph)QEVLSELR ddPTM_A459_Selumetinib_30min_R2 3 DSGSQEVLSELR 12 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2;X6RJY0 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 DSGS(1)QEVLSELR;DS(0.005)GS(0.993)QEVLS(0.001)ELR;DS(0.201)GS(0.79)QEVLS(0.009)ELR 152.11 0.00050463 24490300.0 44012.2 36638.9 43842.6 40964.0 43963.8 27991.4 37674.4 38709.0 30329.9 36729.8 True False 41566.17811879611 39448.98581736811 41021.81484821361 35384.632533158474 38440.67440264127 31846.96126936993 39426.33425040734 38821.63678138007 36396.72748821209 35669.3152385188 1.165320327593768 1.1059642035058665 1.1500589392844502 0.9920188345793389 1.0776958891862807 0.8928391547864322 1.1053291600011257 1.088376284259506 1.0203932215919798 1.0 15.122395899489984 -5.753642551343183 24.992014560872047 1.028924920285526 1.136999489661003 0.44589146418045666 0.05871740288563455 173.43633694503012 555928.0263796138 0.016050015371981863 0.027151273939207635 1.7634268482417298e-06 5.753642551343183 0.10807456937547699 DSGSDQDLDGAGVRAS(ph)DLEDEESAAR ddPTM_A459_Selumetinib_30min_R1 2 DSGSDQDLDGAGVRASDLEDEESAAR 26 1 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 DSGSDQDLDGAGVRAS(0.998)DLEDEES(0.001)AAR;DSGSDQDLDGAGVRAS(0.999)DLEDEESAAR 89.803 2.6443e-05 56374000.0 4424.5 4461.4 4566.2 4655.8 4622.799999999999 3992.9 4640.1 3908.2 2509.4 3668.6 True False 4527.582241421675 3939.057213951408 3946.1351203412114 3842.7519301900384 4204.66855622163 3952.735051263127 4290.093521234056 3804.5418403772765 4258.268520675511 4139.500545190102 1.0937508503731217 0.9515778947120568 0.9532877402145601 0.9283129421628243 1.0157429647176277 0.9548821187754192 1.0363795038555887 0.919082338278218 1.0286913781478813 1.0 12.015240993341862 DSGSDQDLDGAGVRAS(ph)DLEDEESAAR ddPTM_A459_Selumetinib_30min_R2 2 DSGSDQDLDGAGVRASDLEDEESAAR 26 1 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 DSGSDQDLDGAGVRAS(0.994)DLEDEES(0.006)AAR;DSGS(0.001)DQDLDGAGVRAS(0.997)DLEDEES(0.002)AAR 78.268 9.0507e-05 82011000.0 96856.0 90635.0 103233.0 107797.0 111988.0 75691.0 80126.0 86392.0 65130.0 116249.0 True False 91473.13126528807 97586.41306254153 96591.10117159189 93114.86263980267 97919.06625457754 86116.74819551285 83852.01776665698 86643.38641703455 78157.81988424795 112892.5893188246 0.8102669255548303 0.8644182372940683 0.8556017871005243 0.8248093448971496 0.8673648717369772 0.7628202056054096 0.742759274746078 0.7674851550471696 0.6923201988353659 1.0 16.78459125989331 -6.76628851891484 24.983134667951603 0.7753999254437282 0.8451229392187521 0.07610507069561201 0.07825480607901143 219.99754330046028 1133437.408935672 0.025255688046096278 0.022984885322800158 1.7128190363618083e-07 6.76628851891484 0.06972301377502399 DSGSDTASAIIPSTTPS(ph)VDSDDESVVK ddPTM_A459_Selumetinib_30min_R1 1 DSGSDTASAIIPSTTPSVDSDDESVVK 27 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 DSGSDTASAIIPS(0.001)T(0.002)T(0.002)PS(0.892)VDS(0.095)DDES(0.008)VVK 89.62200000000001 2.2656e-05 5644900.0 1271.8 1382.8 1217.6 1105.4 1311.7 1163.6 1454.8 1355.2 569.14 1243.5 True False 1301.4304655079868 1220.9011331537204 1052.2566077980518 912.3626409278897 1193.056966599444 1151.895240464268 1345.0632647338 1319.2556936900078 965.7890116590661 1403.1153377157204 0.927529213405024 0.8701359755224073 0.7499430585023263 0.6502406583433271 0.8502914439961489 0.8209554906153046 0.9586263000471298 0.9402332497040218 0.6883176212950362 1.0 10.454417889707775 -7.078639561117266 7.3763388720247125 0.8920324264310977 0.8041368468803523 0.13786648940777835 0.1040458252526282 0.6133292136734926 50.62152207595327 0.04115963761569747 0.031925373273776515 8.343733781812576e-08 7.078639561117266 -0.08789557955074545 DSGSDTASAIIPSTTPS(ph)VDSDDESVVKDK ddPTM_A459_Selumetinib_30min_R2 1 DSGSDTASAIIPSTTPSVDSDDESVVKDK 29 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 DSGSDTASAIIPS(0.001)T(0.003)T(0.003)PS(0.627)VDS(0.366)DDESVVKDK 102.73 2.0007e-08 4243500.0 24342.0 16279.0 17532.0 23790.0 16628.0 12551.0 20246.0 21143.0 13563.0 22540.0 True False 22989.16908874665 17527.5469547649 16404.0102073983 20549.76095996095 14539.041983793919 14279.786323365826 21187.479116687922 21204.522629587926 16275.978981883232 21889.211634046842 1.050251122474823 0.8007390694465334 0.7494107362863279 0.9388077242579861 0.6642103985681993 0.652366405976669 0.9679416267204694 0.9687202528850358 0.7435616802465058 1.0 14.417932374628716 -10.431587098078072 8.727078662087047 0.9999999999986003 0.8338300966917123 0.12105207968861909 0.131190534703281 9.255116612834547e-11 0.0 0.12958125146232324 0.031428070050562175 3.701799580920867e-11 10.431587098078072 -0.16616990330688808 DSGSDTASAIIPSTTPSVDS(ph)DDESVVKDK ddPTM_A459_Selumetinib_30min_R1 2 DSGSDTASAIIPSTTPSVDSDDESVVKDK 29 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 DSGSDTASAIIPST(0.002)T(0.001)PS(0.045)VDS(0.951)DDESVVKDK;DSGSDTASAIIPS(0.081)T(0.081)T(0.081)PS(0.074)VDS(0.684)DDESVVKDK 115.38 8.1254e-14 38737000.0 4916.5 4290.7 5524.9 5171.3 4509.6 4873.9 4779.6 5973.0 3377.8 4602.8 True False 5031.044884156331 3788.3428493076854 4774.648926103364 4268.229532323496 4101.707476234545 4824.872991147125 4419.070923921963 5814.576636961638 5731.879895248962 5193.614215068696 0.9686982274423296 0.7294232286865338 0.9193306873372015 0.8218225989792813 0.7897597523385343 0.9290010369172764 0.8508662255083405 1.1195626775841934 1.103639904292188 1.0 12.34252313836306 -7.756516570563127 24.99996889724731 1.0837009924690177 0.8544631499644536 0.6506466076914983 0.07238970546407239 64.70289866102921 328591.9665563053 0.03327870327917518 0.018436703485465174 1.7517955929419515e-08 7.756516570563127 -0.22923784250456414 DSGSDTASAIIPSTTPSVDS(ph)DDESVVKDK ddPTM_A459_Selumetinib_30min_R2 1 DSGSDTASAIIPSTTPSVDSDDESVVKDK 29 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 DSGSDTASAIIPSTTPS(0.321)VDS(0.678)DDESVVKDK 122.76 7.3307e-14 8657700.0 77028.0 48066.0 63849.0 65702.0 52921.0 45576.0 70714.0 67229.0 51023.0 56623.0 True False 72747.0921275153 51752.507643450444 59741.024853534946 56753.27425772819 46272.59086025731 51853.68030226443 74002.34111713279 67424.6252596399 61229.02570173476 54988.14686577792 1.3229595153494746 0.9411575147235742 1.0864345910648427 1.0321001432592158 0.8415011870322772 0.94299741413064 1.3457871438687894 1.2261665304746225 1.1134949837678723 1.0 15.746833047261312 -7.24382944499375 24.965651228362205 1.1902093943467127 1.0183020249295502 0.18570068238183546 0.14425370375572255 1172.0419371759497 1661608.8210673232 0.05516799823878667 0.04263486798109535 5.703882296929506e-08 7.24382944499375 -0.17190736941716245 DSGSSSVFAES(ph)PGGK ddPTM_A459_Selumetinib_30min_R1 1 DSGSSSVFAESPGGK 15 0 A0A087WVV7;A0A590UJ70;A0A087X165;Q9C0H9-2;Q9C0H9 A0A087WVV7 SRCIN1 SRC kinase signaling inhibitor 1 1 DSGSSSVFAES(0.999)PGGK 103.3 0.0093111 0.0 1329.3 1508.9 1567.3 1190.2 1084.4 905.82 1551.6 1215.2 530.65 1057.2 True False 1360.270103632464 1332.2372865314217 1354.4692685626517 982.3539128210367 986.3162114663703 896.7082732187554 1434.5615627996729 1182.9689484740973 900.4742928574407 1192.9019180000478 1.1403033921791461 1.1168037090299727 1.1354405992015493 0.8234993154072516 0.8268208782160168 0.7517032705606895 1.2025813196819886 0.9916732722312966 0.7548602942705677 1.0 10.220259712245076 -5.7481422981611905 24.865315206978575 0.9094247456578561 1.1294447878291995 0.38983150138525147 0.12813897483524164 244.87100635953183 457900.36902555614 0.03683401328069888 0.06332176921387776 1.7859023216080466e-06 5.7481422981611905 0.2200200421713434 DSGSSSVSSTSSSSSSS(ph)PGDK ddPTM_A459_Selumetinib_30min_R2 1 DSGSSSVSSTSSSSSSSPGDK 21 0 Q9H7S9 Q9H7S9 ZNF703 Zinc finger protein 703 1 DSGSSSVSSTSSSSSS(0.007)S(0.993)PGDK 306.75 1.4505999999999986e-199 0.0 6788.8 6020.1 5912.6 7900.5 5669.8 5234.5 5218.1 6811.6 4557.4 5460.9 True False 6411.505673719628 6481.822312327547 5532.189753152135 6824.438270877324 4957.509035344889 5955.504860940038 5460.751989468994 6831.420628278914 5469.007344395386 5303.2296278778385 1.2089813422401778 1.2222405528612454 1.0431737151396776 1.286845705304339 0.9348094242957956 1.1229958494788423 1.029703100307612 1.2881623289264588 1.0312597658691023 1.0 12.372655502653906 -5.095424601397103 0.9610780965637347 1.0943708960732303 1.2574995443936743 0.14594921179881748 0.11129019078425978 2.8278464602633586 2.906143254931047 0.0378734190677141 0.43179480336562825 8.027409139895963e-06 5.095424601397103 0.16312864832044394 DSHGVAQVR ddPTM_A459_Selumetinib_30min_R2 2 DSHGVAQVR 9 0 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 0 ; 134.77 0.0039397 29173000.0 191926.0 153697.0 144935.0 154795.0 208460.0 122459.0 131124.0 154168.0 121716.0 163205.0 False True 181259.52126065185 165485.06568625217 135610.03989329629 133711.6539637307 182271.391143955 139326.61567787852 137221.52581727674 154616.60335611374 146062.60102918991 158492.84759248517 1.1436448017307637 1.04411693145766 0.8556224583835804 0.8436447195871478 1.150029126945898 0.8790719442186652 0.8657900208222582 0.9755430967690228 0.9215721923600253 1.0 17.274058210853994 -5.007938160688189 4.302162363468048 0.9353779130372476 1.129811220176994 0.3694189425543314 0.08679380566536543 0.20032852877946059 9.152004925546168 0.02241926469284271 0.08469180531190644 9.818877443349998e-06 5.007938160688189 0.1944333071397465 DSHS(ph)PDLQLPTPEVIPSSGSK ddPTM_A459_Selumetinib_30min_R2 1 DSHSPDLQLPTPEVIPSSGSK 21 0 H3BQK9;H3BPE1;H0Y4F5;H0Y6T5 H3BQK9 MACF1 1 DS(0.197)HS(0.803)PDLQLPTPEVIPSSGSK 95.444 0.00027548 5489600.0 33629.0 25254.0 34519.0 28476.0 27433.0 21637.0 24842.0 26874.0 21544.0 21671.0 True False 31760.03480755322 27190.900595591407 32298.085121445467 24597.519676160056 23986.62128586835 24617.300348869907 25997.202223489145 26952.1988907698 25853.40198965514 21045.30192197999 1.509127069086266 1.292017605468177 1.5346933601229509 1.168789108721224 1.1397613289081117 1.1697290179125097 1.235297185085158 1.2806753255756607 1.2284642950478895 1.0 14.361210586696641 -1.5228787452803376 0.26092265108357654 1.1285895161655521 3.549190080877059 0.519825256228813 0.10711165488769786 46.48884829997915 0.6422741429631127 0.13546344741707173 50.09483476916102 0.029999999999999995 1.5228787452803376 2.420600564711507 DSIS(ph)SDSETSEPLSCR ddPTM_A459_Selumetinib_30min_R2 2 DSISSDSETSEPLSCR 16 0 O75164 O75164 KDM4A Lysine-specific demethylase 4A 1 DSIS(0.999)S(0.001)DSETSEPLSCR;DSIS(0.984)S(0.016)DSETSEPLSCR 335.25 4.192899999999997e-135 29919000.0 77757.0 63796.0 80613.0 83015.0 90213.0 62308.0 65154.0 73298.0 55955.0 62931.0 True False 73435.5772259335 68688.94806352859 75426.44734479809 71708.21379113752 78879.6364255474 70890.36142429114 68183.79010020182 73511.2850448628 67147.56351332876 61114.01851562564 1.2016159141483633 1.1239474957119076 1.234192238978902 1.173351311742054 1.290696281171225 1.1599689096891228 1.1156816677464694 1.2028547104305933 1.0987260393646092 1.0 15.899215727240342 -8.751455155430094 0.7605944903810756 0.9981381298857543 1.1953397910268453 0.5952399296551449 0.04884771879795755 0.701665933135149 0.8285807769198336 0.04901386030899895 0.017695318462769782 1.7723310438223771e-09 8.751455155430094 0.19720166114109094 DSISAVS(ph)SEK ddPTM_A459_Selumetinib_30min_R2 2 DSISAVSSEK 10 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DSIS(0.019)AVS(0.786)S(0.195)EK;DSIS(0.313)AVS(0.575)S(0.112)EK 85.554 0.036302 5814600.0 48600.0 38289.0 42346.0 40667.0 47425.0 34761.0 42159.0 50838.0 30161.0 36237.0 True False 45899.00656121464 41225.64318146034 39621.50446283876 35128.08444551205 41467.04751512067 39549.01222105964 44119.47703647366 50985.930163316065 36194.042768751795 35190.74365496695 1.304292032337779 1.1714911053219985 1.1259069956382248 0.9982194405986629 1.1783509868870832 1.1238470152499191 1.253723918682988 1.4488449196531747 1.028510312928361 1.0 15.102908381161804 -7.255209100651353 23.892443977173027 1.2201735308052306 1.1445586925261748 0.0 0.1371865371653373 857.1801407591516 3287202.2757397266 0.05265529539163362 0.039699769230451265 5.5563666933531164e-08 7.255209100651353 -0.0756148382790558 DSISAVSS(ph)EKVSPSK ddPTM_A459_Selumetinib_30min_R2 1 DSISAVSSEKVSPSK 15 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DSISAVS(0.005)S(0.742)EKVS(0.253)PSK 164.7 0.00043861 24625000.0 30894.0 29882.0 28751.0 35119.0 32676.0 24532.0 35656.0 34849.0 26660.0 28600.0 True False 29177.035158480776 32173.853314225966 26901.19196172192 30335.731616345867 28570.94875285364 27911.06032067649 37314.07465102362 34950.40482043746 31992.744942638605 27774.243688275947 1.0505069187823457 1.158406100102275 0.9685661386011905 1.0922252989791104 1.0286850318417131 1.0049260254909587 1.3434776143616334 1.258374673049719 1.15188536911064 1.0 14.761460006122247 -7.240143894490026 24.952912979547904 1.2099656571435442 1.0526285915993943 0.32634548134077745 0.0950286264589814 796.0363481729668 932754.0736253334 0.03508214687791165 0.027147905638843253 5.752493088032516e-08 7.240143894490026 -0.15733706554414995 DSISAVSSEKVS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 DSISAVSSEKVSPSK 15 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DSISAVSS(0.001)EKVS(0.977)PS(0.022)K;DSISAVSSEKVS(0.992)PS(0.008)K 255.72 2.6258e-28 78511000.0 3650.1000000000004 5091.5 2650.6 2473.4 2354.61 2988.2 3696.0 3095.8999999999996 1867.12 3385.8999999999996 True False 3735.140228141771 4495.384813025866 2290.6630787036092 2041.4671214682842 2141.6359412401603 2958.1414210685175 3417.2077443333296 3013.7866750995395 3168.3662709506903 3820.5132464589133 0.9776540446767796 1.1766442158504398 0.5995694638218404 0.5343436836295337 0.5605623650762526 0.774278540667358 0.8944368266490393 0.7888434041925918 0.8293038308105141 1.0 11.899550747106973 -5.258109594631496 24.981960857508717 0.7320171114816909 1.0771491458150755 0.44009344296785713 0.14781320591420335 255.68807889087145 1918295.6036933518 0.040522067145850285 0.0984673479456269 5.51938139583281e-06 5.258109594631496 0.3451320343333846 DSISAVSSEKVS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 DSISAVSSEKVSPSK 15 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DSISAVS(0.001)S(0.009)EKVS(0.915)PS(0.076)K 60.13399999999999 0.046583 247500000.0 221820.0 128440.0 176870.0 163310.0 190490.0 166070.0 208190.0 219030.0 154510.0 151950.0 True False 209492.13241581546 138290.93500030716 165490.37676149537 141066.89627453612 166558.94319779324 188944.63506663716 217871.24752065862 219667.34103763165 185416.3173701086 147562.8086864872 1.4196811126095035 0.9371665952368857 1.121491100871475 0.955978661088294 1.1287325355243498 1.2804353396936896 1.4764644930522375 1.488636215269785 1.2565247234080856 1.0 17.170969628866153 -6.8071567626174465 3.599279889358986 1.3490496813964696 1.0919712637277306 0.19933226621602318 0.17831347423902438 0.28122699690022024 7.50427871821978 0.06242266539116988 0.05658550518134729 1.5589896694861999e-07 6.8071567626174465 -0.25707841766873907 DSISAVSSEKVS(ph)PSKSPSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R2 1 DSISAVSSEKVSPSKSPSLSPSPPSPLEK 29 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 DS(0.001)IS(0.002)AVS(0.008)S(0.009)EKVS(0.489)PS(0.489)KS(0.001)PSLSPS(0.006)PPS(0.994)PLEK 87.304 9.8776e-06 39957000.0 53905.0 55203.0 48133.0 54929.0 46032.0 43647.0 40992.0 39249.0 27499.0 46825.0 True False 50909.175898812275 59436.89259437845 45036.17518324794 47447.57544218979 40249.04862869869 49658.978061982954 42898.209224107035 39363.20809197826 32999.56838625726 45473.04058403919 1.1195463343764425 1.3070797956545819 0.9903928702549839 1.0434220987378542 0.885118921271913 1.0920531687386879 0.9433767496771283 0.8656383559667781 0.7256952243004385 1.0 15.472723853586903 -5.5281681161115355 0.5330033056833029 0.8779211537711441 1.303818327745674 0.4941812723149912 0.10754658904806218 1.7341768023898787 0.6548357830509558 0.07286774403370382 0.42103875067370017 2.963683920502532e-06 5.5281681161115355 0.42589717397453 DSISAVSSEKVS(ph)PSKSPSLSPSPPSPLEK ddPTM_A459_Selumetinib_30min_R1 2 DSISAVSSEKVSPSKSPSLSPSPPSPLEK 29 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DSIS(0.002)AVS(0.004)S(0.004)EKVS(0.815)PS(0.164)KS(0.01)PS(0.001)LSPSPPSPLEK;DS(0.001)IS(0.004)AVS(0.012)S(0.012)EKVS(0.765)PS(0.156)KS(0.034)PS(0.012)LS(0.004)PSPPSPLEK 98.627 4.6979e-08 98940000.0 8585.0 10642.6 10883.8 12239.900000000001 8739.0 9446.8 8451.9 8678.4 5274.9 8892.3 True False 8785.013796497931 9396.559444389493 9405.839740433996 10102.43123637894 7948.558992995768 9351.77376900812 7814.3663783362745 8448.220640583948 8951.120036547081 10033.713323336957 0.8755496109366876 0.936498696104309 0.937423607524981 1.0068487020535213 0.7921851797886806 0.9320351765738867 0.7788110071035412 0.8419834580019958 0.8921044231678494 1.0 13.29256800361855 -6.260081018796665 24.999625240622144 0.863209370396281 0.9387774364527446 0.17957765897954825 0.0674834331613784 185.45395043301625 3413143.2239716053 0.019457737211514222 0.023778831516081293 5.494383651003731e-07 6.260081018796665 0.0755680660564636 DSISAVSSEKVSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 DSISAVSSEKVSPSK 15 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DSISAVS(0.001)S(0.02)EKVS(0.127)PS(0.852)K 116.0 0.010959 2523300.0 10503.0 13537.0 10833.0 10080.0 12006.0 10919.0 12631.0 13663.0 9855.7 11788.0 True False 9919.285306840278 14575.244371684532 10136.016574078592 8707.086611030114 10497.698944998185 12422.993137186797 13218.366527851684 13702.757067968583 11827.115391266427 11447.649811097795 0.8664909802904819 1.273208441225615 0.8854233612433134 0.7606003638047284 0.9170178262110454 1.0852003111715967 1.154679497187037 1.1969930329878364 1.0331479025328643 1.0 13.482763824693134 -6.834960276220463 5.468714248784959 1.1128292330408336 0.9461779396365878 0.24136499279524237 0.1343422228221175 0.31090589084884857 16.49923776863718 0.05051146068332363 0.04484194640423647 1.4623109220924416e-07 6.834960276220463 -0.16665129340424578 DSITPDIATKPGQPLFLDS(ph)ISPK ddPTM_A459_Selumetinib_30min_R1 1 DSITPDIATKPGQPLFLDSISPK 23 1 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 DSITPDIAT(0.004)KPGQPLFLDS(0.607)IS(0.388)PK 81.34100000000002 0.00027651 57659000.0 2406.8 3530.8 3743.7 4121.9 2431.1 3249.4 2696.2 2782.2 2094.8 2854.2 True False 2462.873757182438 3117.412294575612 3235.3261026721148 3402.0875426457997 2211.2074342455644 3216.7139862191416 2492.8234632769254 2708.4070181407455 3554.7226018614274 3220.564372262331 0.7647335909179042 0.967970807050114 1.00458358495701 1.056363776469388 0.6865900440587283 0.9988044374842027 0.7740331119436084 0.8409727939200256 1.1037576620039309 1.0 11.653097813287117 -8.261330141787576 24.999989243195788 1.051878838748288 0.8923500723810456 0.24021203050747797 0.11712916080233457 14.597632628028869 3342937.06016191 0.09154656535422259 0.029622357669172598 5.478603343567259e-09 8.261330141787576 -0.15952876636724245 DSITPDIATKPGQPLFLDS(ph)ISPK ddPTM_A459_Selumetinib_30min_R2 1 DSITPDIATKPGQPLFLDSISPK 23 1 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 DSITPDIATKPGQPLFLDS(0.904)IS(0.096)PK 91.079 8.5246e-05 12298000.0 61766.0 53854.0 54336.0 57032.0 52414.0 38364.0 51630.0 49253.0 41614.0 51023.0 True False 58333.29298888857 57984.428632097115 50840.08091656368 49264.14321431241 45829.284732894805 43648.292766282095 54030.897302904144 49396.3180757269 49937.96279230913 49549.8334163253 1.1772651685579505 1.1702244918747364 1.0260393912810468 0.9942342853181265 0.9249129931039348 0.8808968619438625 1.0904354985198084 0.9969017990573542 1.0078331116216417 1.0 15.596592586712063 -5.329873075714759 2.6863846025665357 0.9829460533469799 1.1823622918459928 0.6746652910794222 0.05163807182546045 0.16990705140690274 2.357730106955191 0.015220633353858606 0.042963476149472525 4.6787185871494e-06 5.329873075714759 0.1994162384990129 DSITPDIATKPGQPLFLDSIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DSITPDIATKPGQPLFLDSISPK 23 1 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 DSITPDIATKPGQPLFLDS(0.464)IS(0.536)PK 116.83 5.9309e-06 62804000.0 5977.9 6966.7 7051.8 7658.3 5445.0 5853.7 5547.6 5382.7 3452.9 5645.8 True False 6117.173439031446 6151.035525269037 6094.204292764698 6320.921669095398 4952.500711392827 5794.817092734348 5129.140065601614 5239.93331052627 5859.319110161981 6370.4934247490255 0.9602354215242661 0.9655508788962239 0.9566298693738606 0.992218537505895 0.7774124202299035 0.9096339492670684 0.8051401553410572 0.8225317822587196 0.919759070372609 1.0 12.637189405003827 -6.239011291285128 24.982142088844967 0.8620368943228721 0.9675774985132393 0.3660518097234462 0.061135418418149165 763.8900590579922 850880.1838364538 0.0169631208680879 0.021882096182161113 5.767514681523761e-07 6.239011291285128 0.10554060419036715 DSLGDFIEHYAQLGPS(ph)SPEQLAAGAEEGGGPR ddPTM_A459_Selumetinib_30min_R1 4 DSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPR 32 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 DSLGDFIEHYAQLGPS(0.97)S(0.03)PEQLAAGAEEGGGPR;DSLGDFIEHYAQLGPS(0.588)S(0.412)PEQLAAGAEEGGGPR;DSLGDFIEHYAQLGPS(0.569)S(0.43)PEQLAAGAEEGGGPR;DSLGDFIEHYAQLGPS(0.629)S(0.371)PEQLAAGAEEGGGPR 182.48 6.335800000000001e-35 72401000.0 10135.6 11704.400000000001 11548.8 12018.6 12278.8 9919.6 12653.0 10758.4 6143.71 9922.4 True False 10371.739759555558 10334.043406772062 9980.53639301752 9919.777127063448 11168.18470799821 9819.817830276172 11698.574023011257 10473.052283791754 10425.427151175327 11196.036692360654 0.9263760064874086 0.9230090692560204 0.8914347699331406 0.8860079150894502 0.9975123353801219 0.8770798185197524 1.0448852879334967 0.9354249697071634 0.9311712204631185 1.0 13.450700499672237 -6.250836520353655 24.95419698343895 0.9607805492743006 0.9067805084471089 0.2851141402237476 0.044498056723906484 996.3163786988555 2344865.1540139914 0.012767865871968001 0.016313222914242864 5.612592087180472e-07 6.250836520353655 -0.054000040827191675 DSLGDFIEHYAQLGPS(ph)SPEQLAAGAEEGGGPRR ddPTM_A459_Selumetinib_30min_R1 1 DSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRR 33 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 DSLGDFIEHYAQLGPS(0.5)S(0.5)PEQLAAGAEEGGGPRR 72.822 2.7349e-05 2100800.0 762.55 823.32 1468.0 1646.3 933.74 863.47 673.4 646.24 587.2 555.7 True False 780.3159313359923 726.9253116489162 1268.6536631467968 1358.8046098784 849.2833818651865 854.7842757680315 622.6048958425497 629.0996159166401 996.4355126088544 627.0295079763779 1.2444644492957246 1.1593159530799972 2.0232758538607576 2.1670505017597836 1.3544552067511018 1.363228149384373 0.9929435344309269 1.003301452186745 1.5891365556697106 1.0 9.292389527553995 -6.691957176706773 2.7645863792838736 1.1635083535524327 1.6446372243544745 0.28509807259162523 0.3361046879590034 0.3770643851563106 5.86485234178271 0.13298439151372332 0.1285308903629254 2.0325574199095413e-07 6.691957176706773 0.4811288708020418 DSLGDFIEHYAQLGPSS(ph)PEQLAAGAEEGGGPR ddPTM_A459_Selumetinib_30min_R1 2 DSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPR 32 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 DSLGDFIEHYAQLGPS(0.349)S(0.651)PEQLAAGAEEGGGPR;DSLGDFIEHYAQLGPS(0.372)S(0.628)PEQLAAGAEEGGGPR 148.97 9.557299999999997e-21 19190100.0 3554.3999999999996 4325.299999999999 4202.3 4445.4 4764.3 3713.3 4607.9 3996.0 2086.34 3652.2999999999997 True False 3637.2106043415547 3818.891865222581 3631.6507415815954 3669.094340492887 4333.369906205484 3675.9475734066423 4260.322393158427 3890.013099162682 3540.3665997553776 4121.108281414658 0.8825806933403372 0.9266662277341727 0.8812315750012164 0.8903173830786587 1.0515059567223897 0.8919803417892225 1.0337807459152664 0.9439240208042657 0.8590811883593777 1.0 12.008816655343747 DSLGT(ph)YSSR ddPTM_A459_Selumetinib_30min_R2 2 DSLGTYSSR 9 0 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DS(0.314)LGT(0.685)YS(0.001)SR;DS(0.252)LGT(0.748)YSSR 126.39 0.011263 84300500.0 137470.0 107423.0 132413.0 180356.0 157116.0 152185.0 167362.0 183693.0 124231.0 136852.0 True False 129829.96773601188 115661.99868061361 123893.69174037369 155791.20166854665 137377.68344513886 173147.10235211768 175144.66462151174 184227.51621798694 149080.671304161 132900.72717580217 0.9768943368103 0.8702886819243282 0.9322273427178928 1.1722373908644215 1.0336864693254426 1.3028303609135057 1.3178608450338194 1.3862039744469514 1.121744586897225 1.0 17.01998947288125 -6.0397497531219475 1.218077726869607 1.2454187219436965 0.9075325377904632 0.48148974899354624 0.12164301747391801 0.3582349542635361 1.0823458687735832 0.045695994238815915 0.08397038457942431 9.125365048699147e-07 6.0397497531219475 -0.33788618415323335 DSLIDSLT(ph) ddPTM_A459_Selumetinib_30min_R1 1 DSLIDSLT 8 0 P56537;P56537-2 P56537 EIF6 Eukaryotic translation initiation factor 6 1 DSLIDS(0.119)LT(0.881) 97.071 0.008612100000000001 2466500.0 3253.7 3477.4 4315.6 4277.3 3840.1 3280.2 3512.8 3642.1 1858.9 2923.7 True False 3329.5048794019017 3070.264391400598 3729.5652238939488 3530.34984986508 3492.7636330247187 3247.204166183305 3247.8266678284967 3545.499676791896 3154.417531315736 3298.9853742496616 1.009251179283928 0.9306692946763715 1.130518871955357 1.0701320101087266 1.0587387444296055 0.9843038988682592 0.984492593747009 1.0747242787029037 0.9561780891596687 1.0 11.687806666522416 -6.760387528800629 24.99983968663427 1.0036445910086427 1.0405139153349572 0.11401348868255956 0.05514798793084324 77.37733112108062 1839126.4568176488 0.01967967627846229 0.018621395032608453 1.7362508493610694e-07 6.760387528800629 0.03686932432631451 DSLIT(ph)PHVSR ddPTM_A459_Selumetinib_30min_R2 1 DSLITPHVSR 10 0 P49792;H7BZ48;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD6;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 DSLIT(0.999)PHVS(0.001)R 86.46700000000001 0.047475 8110200.0 34897.0 32584.0 69287.0 99490.0 118410.0 73160.0 56389.0 61325.0 92150.0 91971.0 True False 32957.56444375941 35083.08802592661 64829.14985398163 85939.29037017732 103534.27720116913 83237.12591964327 59011.20023268377 61503.445597099715 110582.57488612723 89315.55826064436 0.3690013821285344 0.39279929173756817 0.7258438632247532 0.9621984348951357 1.1591964403226491 0.9319443055680986 0.6607046004289067 0.6886084215878471 1.238110997004806 1.0 16.446623886031396 -5.405689954119669 2.61996869642098 0.9306739365443074 0.3657578076120845 0.6386300694524011 0.1691668348948709 0.1945936563433344 2.5528845258022272 0.05032465378129962 0.13029127044700237 3.929253474583697e-06 5.405689954119669 -0.5649161289322229 DSLITPHVS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 DSLITPHVSR 10 0 P49792;H7BZ48;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD6;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 DSLIT(0.002)PHVS(0.998)R;DSLITPHVS(1)R;DSLIT(0.026)PHVS(0.974)R 101.56 0.016232 39796000.0 20164.5 25442.2 18706.9 21013.7 22672.9 20582.5 24085.9 20914.8 9305.93 17983.6 True False 20634.293616713177 22463.415396242122 16166.605729646326 17344.051771002705 20622.14019822561 20375.45873741476 22269.08117133066 20360.071563155085 15791.483531764516 20291.970235098044 1.0168698937387082 1.1070100702882086 0.7966996571719648 0.8547248773804889 1.016270966264108 1.0041143615602348 1.0974331675695495 1.0033560727355715 0.7782134188453887 1.0 14.308621328942102 DSLITPHVS(ph)R ddPTM_A459_Selumetinib_30min_R2 4 DSLITPHVSR 10 0 P49792;H7BZ48;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD6;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 DSLIT(0.008)PHVS(0.992)R;DSLIT(0.002)PHVS(0.998)R;DSLIT(0.003)PHVS(0.997)R;DSLIT(0.001)PHVS(0.999)R 93.494 0.016631 44967100.0 343394.0 289099.0 395142.0 407196.0 438487.0 326057.0 321089.0 351779.0 310551.0 349734.0 True False 324309.53619509767 311271.963700202 369718.9939180794 351735.2023477191 383400.3429364832 370968.3920992502 336020.2747257829 352802.6186498513 372669.8775199312 339636.2707019412 0.9548730926906979 0.9164862252694111 1.088573352763428 1.0356232024947527 1.1288557083261244 1.0922519886717443 0.9893533279920753 1.0387660243727757 1.0972617169235723 1.0 18.373631010970925 -5.258994351072453 24.99796031350479 1.0606037946369813 0.9356796491098109 0.5688667476039317 0.042863944807623774 147.0075215752207 1502978.2884956067 0.011239171564337975 0.027029350891769267 5.508148608828136e-06 5.258994351072453 -0.12492414552717035 DSLLDGHFVLATLSDTDSHSQDLGS(ph)PER ddPTM_A459_Selumetinib_30min_R1 4 DSLLDGHFVLATLSDTDSHSQDLGSPER 28 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 1 DSLLDGHFVLATLSDT(0.001)DS(0.003)HS(0.105)QDLGS(0.891)PER;DSLLDGHFVLATLSDTDS(0.002)HS(0.058)QDLGS(0.94)PER;DSLLDGHFVLATLS(0.405)DT(0.116)DS(0.001)HS(0.051)QDLGS(0.428)PER;DSLLDGHFVLAT(0.002)LS(0.04)DT(0.359)DS(0.004)HS(0.072)QDLGS(0.522)PER 131.92 1.4829e-12 24560100.0 9832.5 11940.099999999999 10588.51 11562.5 12429.2 10121.099999999999 11028.400000000001 9936.0 4676.4400000000005 8456.6 True False 10061.578119285487 10542.1475411981 9150.648500522126 9543.326430006082 11304.981054553495 10019.290923223532 10196.518908984226 9672.465003323437 7935.577126336092 9542.086984259557 1.0544420875520075 1.1048052232795849 0.9589776864973941 1.000129892522314 1.1847493188022677 1.0500104368940633 1.068583730771288 1.013663469980828 0.8316395710316273 1.0 13.220089122439756 -8.05065515411934 6.134872292220342 0.9158569245588227 1.0590497031536696 0.4158398253354414 0.06766179890189863 0.21124966426365893 18.542618205787566 0.045875682633920355 0.01741135104478386 8.89907456824428e-09 8.05065515411934 0.14319277859484691 DSLLDGHFVLATLSDTDSHSQDLGS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 DSLLDGHFVLATLSDTDSHSQDLGSPER 28 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 1 DSLLDGHFVLAT(0.001)LSDT(0.001)DS(0.007)HS(0.069)QDLGS(0.923)PER 68.304 0.00035428 1729700.0 12821.0 12507.0 16702.0 19534.0 21080.0 17651.0 17374.0 15489.0 13764.0 14268.0 True False 12108.46014652949 13466.24668365652 15627.411503762627 16873.435501970453 18431.74194240895 20082.2650301753 18181.925425927875 15534.07042565802 16517.18459829249 13856.045767283962 0.8738755883095621 0.971867941967411 1.1278406383920228 1.2177670155948073 1.3302310234806556 1.4493503678800124 1.312201600030646 1.1211041509646356 1.1920561519284127 1.0 13.758227980035945 -5.312087538948848 1.669551180732154 1.2548478139346926 0.8720668178223426 0.5274998650945164 0.11617416272851627 0.35184233037179014 1.7042508669553633 0.0359273133099855 0.15347170069702865 4.874302308980841e-06 5.312087538948848 -0.38278099611234995 DSLLQDGEFSMDLR ddPTM_A459_Selumetinib_30min_R1 8 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 ;;;;;;; 255.24 4.7706e-27 440219700.0 14474.8 15963.539999999997 17455.969999999998 17285.100000000002 17143.3 14640.64 15098.810000000001 14458.99 9203.140000000001 12181.539999999999 False True 14812.03467694214 14094.521315551592 15085.54515277969 14266.58176651226 15592.691541895443 14493.368454237532 13959.894605578329 14075.49061578134 15617.05640924907 13745.159317247737 1.077618260732392 1.0254170934101483 1.0975169370245135 1.0379349876730952 1.1344133001302779 1.0544343735653123 1.0156226118136833 1.0240325550915292 1.136185914531557 1.0 13.7466360084717 -9.814390901789283 8.478835891185808 1.0000034214903746 1.0646735282537514 0.18455535246345822 0.04200291823659811 0.0 0.0 0.03992021701766904 0.00968207478596642 1.533236319086109e-10 9.814390901789283 0.06467010676337681 DSLLQDGEFSMDLR ddPTM_A459_Selumetinib_30min_R2 3 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 ;; 292.39 1.227e-65 28803800.0 44268.0 34974.6 45018.0 50250.0 56989.0 34694.9 29280.699999999997 42971.0 36076.6 49456.0 False True 41807.761778844666 37657.039358936076 42121.59089189238 43405.863313914975 49829.532331875846 39473.80754605567 30642.310568606317 43096.038495768014 43292.9280644259 48028.07677788023 0.8704858612639599 0.7840630290713487 0.8770201456680411 0.9037601800017514 1.0375083841546886 0.8218902399239041 0.6380082781644697 0.8973092696398847 0.901408737739939 1.0 15.551590418427356 DSLS(ph)DDGVDLK ddPTM_A459_Selumetinib_30min_R2 3 DSLSDDGVDLK 11 0 P07948;P07948-2;E5RJ37 P07948 LYN Tyrosine-protein kinase Lyn 1 DS(0.011)LS(0.989)DDGVDLK;DS(0.002)LS(0.998)DDGVDLK;DS(0.001)LS(0.999)DDGVDLK 161.25 0.00060989 8493100.0 95199.0 29253.3 59566.0 60431.0 38837.0 37989.9 109032.0 69328.0 44816.0 36328.2 True False 89908.2206917917 31496.934045815073 55733.588410557146 52200.19355071037 33957.94885281481 43222.66388702376 114102.20404280929 69529.73300213178 53780.452263664294 35279.310474000915 2.5484687621105735 0.8927876883825928 1.579781114249101 1.4796262412548935 0.9625457072875649 1.2251561412708647 3.234252668483895 1.970835939477097 1.5244190303350116 1.0 15.106534743578083 DSLS(ph)PVLHPSDLILTR ddPTM_A459_Selumetinib_30min_R1 2 DSLSPVLHPSDLILTR 16 0 Q9HCN4-3;Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5 Q9HCN4-3 GPN1 GPN-loop GTPase 1 1 DS(0.004)LS(0.928)PVLHPS(0.04)DLILT(0.027)R;DS(0.081)LS(0.919)PVLHPSDLILTR 135.57 0.00041208 19360700.0 2900.4700000000003 2777.45 2673.46 3020.7400000000002 4880.4 2929.98 4172.5 2803.55 768.15 1541.1999999999998 True False 2968.045307667833 2452.2648627985254 2310.4188162646014 2493.224465312569 4438.968681704604 2900.507061408986 3857.764965700976 2729.190746786173 1303.4944465437532 1739.0280325592823 1.7067265461499421 1.410135326679922 1.3285690471961042 1.4336884849655676 2.552557289816593 1.667889767791946 2.218345474295549 1.5693770863312042 0.7495534414275279 1.0 10.764065473263056 -8.170729078176839 4.723665147385232 0.8794648395177259 1.752023476085317 0.48035169661447596 0.3614487269304511 0.19556679961325515 7.173498658968265 0.2830103434618146 0.09908158115869993 6.749489434183684e-09 8.170729078176839 0.8725586365675911 DSLS(ph)PVLHPSDLILTR ddPTM_A459_Selumetinib_30min_R2 2 DSLSPVLHPSDLILTR 16 0 Q9HCN4-3;Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5 Q9HCN4-3 GPN1 GPN-loop GTPase 1 1 DS(0.429)LS(0.571)PVLHPSDLILTR;DS(0.053)LS(0.947)PVLHPSDLILTR 71.872 0.025672000000000004 13012400.0 8113.2 6556.700000000001 13657.7 20716.1 19459.8 12922.4 8508.099999999999 10973.8 13992.9 17609.8 True False 7662.300823712889 7059.577806886603 12778.97845137942 17894.53144273421 17015.085951180718 14702.343302132296 8903.743508480316 11005.731941189611 16791.870994292847 17101.359318244806 0.4480521507748372 0.4128079923655543 0.7472492808069358 1.0463806478613193 0.994955174880628 0.8597178170770853 0.52064536758673 0.6435588970666212 0.9819027062005663 1.0 14.061823383242462 -5.33925509163807 4.132535129980996 0.8430223120323992 0.42781990922820773 0.5296481246924468 0.1597482987950855 0.18781006881947737 5.999097960617652 0.04720386533839316 0.10813835154301066 4.57872866836319e-06 5.33925509163807 -0.41520240280419146 DSLYVDGDCTMDIR ddPTM_A459_Selumetinib_30min_R1 3 DSLYVDGDCTMDIR 14 0 C9J712;C9J0J7;C9JQ45;C9J2N0;G5E9Q6;P35080-2;P35080 C9J712 PFN2 Profilin;Profilin-2 0 ;; 286.71 3.0187e-54 40058500.0 5066.57 5540.0 5962.22 6556.490000000001 5609.34 4943.29 5351.129999999999 5590.400000000001 3147.06 4472.6900000000005 False True 5184.611223170939 4891.374224523873 5152.58327213017 5411.522102060155 5101.976187409411 4893.564990748204 4947.489955880519 5442.124431821587 5340.330967831782 5046.803329189967 1.0273059766731767 0.9692024645051818 1.0209597909885624 1.0722672846712111 1.0109322386113864 0.9696365543797882 0.9803215289299992 1.0783309903013538 1.0581611010962313 1.0 12.301154151458768 -7.761461033202713 24.999999999998458 1.051184531497689 1.0074952258658951 0.20114669541673946 0.034386743920432464 0.8908502590884232 1021758.5129121044 0.01837877980514592 0.009704529203169946 1.7319644231895315e-08 7.761461033202713 -0.04368930563179396 DSLYVDGDCTMDIR ddPTM_A459_Selumetinib_30min_R2 1 DSLYVDGDCTMDIR 14 0 C9J712;C9J0J7;C9JQ45;C9J2N0;G5E9Q6;P35080-2;P35080 C9J712 PFN2 Profilin;Profilin-2 0 172.56 0.017795 2245000.0 8632.0 9329.1 10617.0 9637.4 13783.0 8606.8 9652.3 9988.1 8956.3 10132.0 False True 8152.267996633839 10044.611972215562 9933.913778915577 8324.769494557697 12051.456318416629 9792.308575248588 10101.151075669597 10017.163717381038 10747.810259930751 9839.462833902513 0.8285277493548394 1.0208496278481987 1.009599197294351 0.8460593464385229 1.224808358124241 0.9952076389280671 1.0265957853781835 1.0180600187711717 1.0923167698645568 1.0 13.264363841281634 -3.81160064548379 0.9335807020823815 1.0360647790518538 3.0386516728295613e-43 0.2946518174260737 0.08941948923669352 14.302102290309065 2.533408892003634 0.028951374417170328 23.027493896188137 0.00015431187721474322 3.81160064548379 -1.0360647790518538 DSNAPKS(ph)PLTGYVR ddPTM_A459_Selumetinib_30min_R1 2 DSNAPKSPLTGYVR 14 1 H0YNS8;H0YKM5;Q9NP66 H0YNS8 HMG20A High mobility group protein 20A 1 DSNAPKS(0.77)PLT(0.23)GYVR;DSNAPKS(0.558)PLT(0.442)GYVR 194.32 0.00034591 36306000.0 2292.2 2398.3 4413.5 5439.8 2942.3999999999996 2782.4 2391.1000000000004 2207.31 1513.1 1629.3400000000001 True False 2345.6038001552197 2117.505921060579 3814.170941620152 4489.841047692722 2676.2604395229137 2754.4115822170684 2210.7374019143463 2148.7649684466437 2567.620187548465 1838.4816601155883 1.2758374755871906 1.1517688574208829 2.0746309437649484 2.442146225929955 1.4556905829317073 1.498199107432975 1.202479986542457 1.168771500451926 1.3965982056013735 1.0 10.844299069583899 -6.9357320986629345 2.1411293767286774 1.2089978284189278 1.721993190032754 0.2905695260417027 0.36120775881578426 0.4687487443445371 4.360079478601904 0.16986923795244277 0.13906970664434792 1.1594923865894799e-07 6.9357320986629345 0.5129953616138263 DSNAPKS(ph)PLTGYVR ddPTM_A459_Selumetinib_30min_R2 3 DSNAPKSPLTGYVR 14 1 H0YNS8;H0YKM5;Q9NP66 H0YNS8 HMG20A High mobility group protein 20A 1 DSNAPKS(0.877)PLT(0.123)GYVR;DSNAPKS(0.944)PLT(0.034)GY(0.022)VR;DSNAPKS(0.99)PLT(0.01)GYVR 198.61 0.00043415 34902400.0 85958.5 136294.0 115585.0 108917.0 110889.0 55193.799999999996 27240.100000000002 35657.7 27955.1 119607.0 True False 81181.27068913936 146747.31154571712 108148.38693943244 94082.31670769531 96958.13245976201 62796.24495056876 28506.818625234133 35761.45800354997 33546.901130756036 116153.6351336932 0.6989128716953151 1.263389745631383 0.9310805194770987 0.8099816815841042 0.834740405224192 0.5406309055957662 0.24542338767463193 0.30788066135328795 0.28881490529455617 1.0 16.82567477974399 -6.7309319974230934 2.068446849260355 0.39890159096321026 0.9500118236922716 0.4374429382506666 0.24249567459883473 0.2553843662542 2.2481034007143412 0.09182302364810233 0.08619329479052631 1.8580953760843195e-07 6.7309319974230934 0.5511102327290613 DSNNLCLHFNPR ddPTM_A459_Selumetinib_30min_R1 2 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 ; 145.14 0.0009712 61691000.0 7776.9 8934.7 9579.3 10215.8 9911.8 8650.5 8026.7 8378.1 4201.7 7037.3 False True 7958.086638786807 7888.621170370664 8278.483675328413 8431.802304316207 9015.279440070417 8563.483824025567 7421.2395566667565 8155.88557209582 7129.978019973818 7940.606004106827 1.0022014232504346 0.9934532913849048 1.0425506152863948 1.0618587926356422 1.1353389697723042 1.0784421012195533 0.9345936006431427 1.0271112265081093 0.8979135869839459 1.0 12.95503339854891 -7.258399027375907 24.99412188608814 0.9671638715835253 1.0533971486626492 0.4299341780603536 0.04926819538483298 287.4460110485556 2363051.279012125 0.020650469356114882 0.015301455804195325 5.51570426528824e-08 7.258399027375907 0.08623327707912387 DSNNLCLHFNPR ddPTM_A459_Selumetinib_30min_R2 3 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 ;; 182.92 0.00014648 31375400.0 121988.0 100400.0 109507.0 142188.0 149377.0 118857.0 113445.0 121355.0 103813.0 113035.0 False True 115208.39531665527 108100.35716311802 102461.43884220652 122821.74911201859 130610.92581267667 135228.47287357904 118720.41728700296 121708.12295859809 124578.50077757455 109771.38584979952 1.0495302981261 0.9847771924008687 0.933407536481363 1.1188867495949801 1.1898449199811683 1.2319100449238432 1.0815242639775762 1.1087417910996553 1.1348904800020985 1.0 16.744142509904172 -5.836593370188879 7.090863029256374 1.134602775019659 0.9892213489414377 0.47574043711591396 0.06405719681897454 0.17502320737911486 13.64903101659546 0.01827492850335106 0.0273552443274176 1.4568224647113134e-06 5.836593370188879 -0.14538142607822135 DSPAFPDS(ph)PWR ddPTM_A459_Selumetinib_30min_R1 1 DSPAFPDSPWR 11 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 DSPAFPDS(1)PWR 148.89 0.00064087 13254000.0 4290.5 5214.1 3348.3 3488.4 3494.6 3245.4 3474.2 3507.7 2451.4 3759.1 True False 4390.46030214029 4603.630748030674 2893.619250895382 2879.2164253780065 3178.514047021742 3212.754222587431 3212.138296905532 3414.6644013846203 4159.846756827907 4241.617101734755 1.0350911449184463 1.0853480259092365 0.6821971860005791 0.6788015882434206 0.7493637381181294 0.7574361724620227 0.7572909623529709 0.8050383425670544 0.9807218938094611 1.0 12.050398676779732 -5.25130337762507 24.866730566350927 0.7850171588798266 1.0602196275297833 0.48667219931198946 0.10527868793815325 503.6935953638743 1235708.6322729043 0.026871546838447433 0.0693013970988599 5.6065619125665004e-06 5.25130337762507 0.2752024686499567 DSPAFPDS(ph)PWR ddPTM_A459_Selumetinib_30min_R2 3 DSPAFPDSPWR 11 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 DSPAFPDS(1)PWR;DSPAFPDS(1)PWR;DSPAFPDS(1)PWR 187.74 1.9366e-05 18493600.0 70090.0 64935.0 69309.0 69074.0 83353.0 77172.0 78402.0 75073.0 58881.0 73159.0 True False 66194.67839250066 69915.30570106635 64849.73439793341 59666.002040703745 72881.45095472551 87801.74250233357 82047.84835061563 75291.4500009958 70658.84527259957 71046.70958009036 0.9317064616184646 0.9840752107210736 0.9127760424264103 0.8398137280860665 1.0258244383938269 1.2358312302043404 1.1548437476632718 1.0597457707189153 0.9945407139924819 1.0 16.11648021434599 -6.5173319434934145 24.939554617812817 1.1006183154845406 0.9229752212859365 0.5412520855447015 0.07422890146989486 188.6480524888039 848204.4681230396 0.025469046597446723 0.026226346583135725 3.0385616796941707e-07 6.5173319434934145 -0.17764309419860413 DSPAFPDS(ph)PWRER ddPTM_A459_Selumetinib_30min_R2 1 DSPAFPDSPWRER 13 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 DSPAFPDS(1)PWRER 95.57 0.035824 0.0 4203.6 4739.3 4089.7 4894.2 5357.4 3543.0 2151.3 2795.7 2089.4 4669.3 True False 3969.9807403440723 5102.78907074865 3826.5731545286803 4227.601517034085 4684.355516236325 4031.0160898482277 2251.3397127200797 2803.8350241469484 2507.338382713769 4534.485176701636 0.8755085937301086 1.125329309039752 0.8438826030769191 0.9323222708402861 1.0330512359605293 0.8889688537432535 0.49649290382236816 0.6183359113297279 0.5529488541712679 1.0 12.146723048165383 -7.106086185286269 5.4645364229483135 0.6370100303519541 0.9627707024027137 0.4739799879573763 0.14612022300687832 0.1747255695611467 7.468995207951532 0.05317389098179997 0.04114034971595722 7.83274187397464e-08 7.106086185286269 0.32576067205075954 DSPPT(ph)PTMYK ddPTM_A459_Selumetinib_30min_R2 2 DSPPTPTMYK 10 0 Q9C0B5-2;Q9C0B5;H0YEF4 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5;Palmitoyltransferase 1 DS(0.215)PPT(0.523)PT(0.262)MYK;DS(0.001)PPT(0.998)PT(0.002)MYK 137.4 0.004094400000000001 18934300.0 265330.0 78507.0 165587.0 202250.0 124842.0 107943.0 347440.0 197216.0 122921.0 104866.0 True False 250584.02080014593 84528.23446020798 154933.3126974941 174703.20109928987 109158.23185835952 122811.1684410068 363596.6484392987 197789.86590913346 147508.634699703 101838.24610541062 2.460608174072162 0.8300244524313055 1.5213666635335206 1.7154969550286467 1.0718785528314394 1.2059434754393505 3.570334941382901 1.942196311044137 1.448460085879915 1.0 16.635919952394225 DSPQSLT(ph)DESCSEK ddPTM_A459_Selumetinib_30min_R1 2 DSPQSLTDESCSEK 14 0 Q9BV36;Q9BV36-4;Q9BV36-2 Q9BV36;Q9BV36-2 MLPH Melanophilin 1 DSPQS(0.014)LT(0.832)DES(0.154)CSEK;DSPQSLT(0.95)DES(0.05)CSEK 243.99 1.8531999999999999e-78 3588600.0 1463.58 1689.76 1900.1999999999998 1895.4 1630.27 1437.08 1707.3 1363.67 840.54 1337.06 True False 1497.6785663690675 1491.9221136518888 1642.16327705146 1564.4039710645213 1482.812366347546 1422.624279964241 1578.5169864448833 1327.50104177557 1426.3349893873408 1508.6846750672944 0.9927048316456611 0.9888892876739416 1.0884734923009753 1.0369323669273314 0.9828510827031538 0.9429566717782065 1.0462868832246035 0.8799062280634337 0.9454162377063449 1.0 10.559075589364486 -6.420974560124609 3.9787798311137434 0.9606940440589864 1.028106666713494 0.286488902187791 0.04744380760394141 0.31056594176777286 8.691967276259009 0.015728760878643125 0.017738487346870512 3.7933720493959806e-07 6.420974560124609 0.06741262265450754 DSPQSLT(ph)DESCSEK ddPTM_A459_Selumetinib_30min_R2 3 DSPQSLTDESCSEK 14 0 Q9BV36;Q9BV36-4;Q9BV36-2 Q9BV36;Q9BV36-2 MLPH Melanophilin 1 DSPQS(0.015)LT(0.953)DES(0.025)CS(0.007)EK;DSPQS(0.002)LT(0.973)DES(0.025)CSEK;DSPQSLT(0.974)DES(0.025)CS(0.001)EK 276.14 4.8428999999999994e-45 7399800.0 60955.1 46697.7 51693.0 46695.0 41272.7 32453.1 37709.1 37237.3 28970.6 34091.7 True False 57567.45956459866 50279.26343322838 48367.128659082875 40335.06044663205 36087.654443380525 36923.21994508991 39462.64786916412 37345.65437803314 34765.52950619676 33107.38404012577 1.738810275521242 1.518672190236791 1.4609166523233146 1.2183101025966419 1.0900182992302474 1.1152563398044193 1.1919591055981904 1.1280158629498072 1.0500838563403663 1.0 15.014865401113862 -5.389783961543386 0.9385656377567286 1.0941781538867097 1.7913229583972776 0.933982616100117 0.05865074076439944 0.2350085064940243 0.29926765275117706 0.022663020729541513 0.13805087045032857 4.075829782847181e-06 5.389783961543386 0.6971448045105679 DSPSKS(ph)SAEAQTPEDTPNKSGAEAK ddPTM_A459_Selumetinib_30min_R1 1 DSPSKSSAEAQTPEDTPNKSGAEAK 25 2 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7;O43493-4 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 DS(0.029)PS(0.11)KS(0.43)S(0.43)AEAQTPEDTPNKSGAEAK 82.94200000000002 5.4336e-05 12248000.0 1593.8 974.22 3677.7 2781.6 2267.6 1756.8 1091.3 1869.7 1048.6 804.74 True False 1630.932439005055 860.1578694974093 3178.2885401600643 2295.845777098804 2062.4959803772967 1739.1281870467753 1008.98236238933 1820.1094823584754 1779.3976132861799 908.036217831403 1.7961094579466144 0.9472726446436927 3.5001781622219212 2.5283636621695615 2.2713807443749396 1.9152630180327048 1.1111697337348607 2.004445909333122 1.959610837479353 1.0 9.826606031612169 -6.989787197677852 5.529257168712333 1.589105139944053 2.219646652073779 0.1896994417255865 0.6650675546080537 0.3364212290525048 34.13903242290883 0.25769203650817896 0.21763463913919914 1.0237945240599437e-07 6.989787197677852 0.630541512129726 DSPSKS(ph)SAEAQTPEDTPNKSGAEAK ddPTM_A459_Selumetinib_30min_R2 1 DSPSKSSAEAQTPEDTPNKSGAEAK 25 2 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7;O43493-4 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 DS(0.027)PS(0.125)KS(0.411)S(0.411)AEAQT(0.006)PEDT(0.018)PNKS(0.002)GAEAK 44.106 0.028638 4831900.0 15247.0 12378.0 11497.0 14089.0 10093.0 5158.3 6835.2 6225.4 4346.1 9883.5 True False 14399.632778576952 13327.352798456895 10757.295536987132 12170.053895119367 8825.027107435177 5868.809002614766 7153.05034369185 6243.51488332955 5215.441440180101 9598.137674583058 1.5002527851531855 1.388535281562924 1.120769038922379 1.2679599217822255 0.9194520235737851 0.6114528882155992 0.7452539842842562 0.6504923241373246 0.5433805616261552 1.0 13.228538791716373 -6.222037971674243 1.1961602340790662 0.6767805819082783 1.3967094328811462 0.7985979250667912 0.14432509913343733 0.19421598747655758 0.5701568711336584 0.05769535493787526 0.08781264446954598 5.997386370081952e-07 6.222037971674243 0.719928850972868 DSPSKSS(ph)AEAQTPEDTPNK ddPTM_A459_Selumetinib_30min_R1 2 DSPSKSSAEAQTPEDTPNK 19 1 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7;O43493-4 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 DS(0.014)PS(0.175)KS(0.111)S(0.7)AEAQTPEDTPNK;DS(0.001)PS(0.05)KS(0.147)S(0.802)AEAQTPEDTPNK 133.98 0.00011871 144814000.0 18080.5 17547.3 16823.9 14321.2 14567.8 17413.5 17708.9 21930.0 10134.2 14857.3 True False 18501.740471471265 15492.853958481537 14539.306787067711 11820.271262218645 13250.145062153992 17238.336000192972 16373.103415482807 21348.345161320747 17196.997227317188 16764.37917735729 1.10363409677947 0.9241531579891052 0.8672737972131496 0.7050825525459139 0.7903749325862436 1.028271659679222 0.9766602891920414 1.2734348785283243 1.025805790085219 1.0 14.033111437430218 -7.126954533810437 2.2108382579450914 1.1005521069687876 0.873941882124086 0.33495944521308463 0.12434258313768395 0.3450301616181537 3.3098982935938954 0.059209408221938244 0.04256790341516642 7.465269080498046e-08 7.126954533810437 -0.2266102248447016 DSPSKSS(ph)AEAQTPEDTPNK ddPTM_A459_Selumetinib_30min_R2 1 DSPSKSSAEAQTPEDTPNK 19 1 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7;O43493-4 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 DS(0.007)PS(0.122)KS(0.084)S(0.787)AEAQTPEDTPNK 71.634 0.0077313999999999985 62244000.0 139240.0 48474.0 98605.0 110510.0 86617.0 73453.0 105930.0 88964.0 74219.0 68439.0 True False 131501.5982218831 52191.799931523674 92260.86165300636 95458.34735961683 75735.39809419526 83570.48401005408 110855.95489631301 89222.87051121693 89064.8738521266 66462.98824412297 1.9785688500623684 0.7852761561039014 1.3881539799884726 1.4362632478845516 1.1395123826815328 1.2573988353201053 1.6679351594775083 1.3424444622245302 1.340067249534213 1.0 16.020263539086457 -11.595755496479102 1.6460591554414952 0.5338684580283264 1.3536431852777269 0.1214165512370694 0.2959382120258708 634572.432733045 147422.6316442371 1109610.8425475 0.0762664302135078 2.536556284817268e-12 11.595755496479102 0.8197747272494005 DSQDAGGFGPEDR ddPTM_A459_Selumetinib_30min_R1 2 DSQDAGGFGPEDR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 168.83 0.0037365 13519900.0 4408.7 4338.6 4386.2 4322.5 4703.9 3571.1 3900.1000000000004 3768.8999999999996 2557.66 3058.6000000000004 False True 4511.414132163125 3830.634695039582 3790.578131671988 3567.6565183741623 4278.433075540999 3535.1779762993733 3605.9123170114776 3668.936528887448 4340.162215904569 3451.2011032869345 1.3072011734889748 1.1099424752128393 1.0983359179103849 1.0337434451374958 1.2396939348061191 1.0243326512999948 1.044828223303822 1.0630897531277275 1.2575802122255308 1.0 11.752882827476828 -4.760252728421967 4.876322580006989 1.0965166184011947 1.3218921680295916 0.36801724649781364 0.0828858679055149 0.19738105984875104 11.793630836543834 0.019965150713980737 0.15400997831376492 1.7367898467657063e-05 4.760252728421967 0.2253755496283969 DSQDAGGFGPEDR ddPTM_A459_Selumetinib_30min_R2 2 DSQDAGGFGPEDR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 160.38 0.0050416 38446000.0 79183.0 72877.0 87781.0 87467.0 90090.0 65227.0 74112.0 69959.0 59465.0 74962.0 False True 74782.32585466372 78466.43156351117 82133.2660287265 75553.84371100899 78772.0887851812 74211.4271782474 77558.35485014204 70162.56910766412 71359.66159092296 72797.65228533364 1.0272628787745939 1.0778703584554967 1.1282405881277808 1.03786099330336 1.0820690820691647 1.0194206110847148 1.0653963749565525 0.9638026351819535 0.9802467435519155 1.0 16.15160430399922 -7.558779383547765 1.4604706029686503 0.9777053918146237 1.0695016948631475 0.5281649442721545 0.03306447147676451 0.31562958106284544 1.2865294292338167 0.023348385664315234 0.01069691441580835 2.7619805533166056e-08 7.558779383547765 0.09179630304852382 DSQDAS(ph)AEQSDHDDEVASLASASGGFGTK ddPTM_A459_Selumetinib_30min_R2 3 DSQDASAEQSDHDDEVASLASASGGFGTK 29 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 DS(0.01)QDAS(0.716)AEQS(0.274)DHDDEVASLASASGGFGTK;DS(0.41)QDAS(0.447)AEQS(0.121)DHDDEVAS(0.008)LAS(0.007)AS(0.007)GGFGTK;DS(0.006)QDAS(0.706)AEQS(0.288)DHDDEVASLASASGGFGTK 90.164 1.4565000000000004e-06 243828200.0 200164.0 181179.0 230038.0 229379.0 244256.0 173281.0 167873.0 190521.0 172224.0 192128.0 True False 189039.68619997884 195074.84671769416 215237.6055264369 198137.1844991543 213570.3776036547 197148.88486169657 175679.42713403873 191075.38456755065 206673.61234062212 186580.76543150618 1.0131788545447646 1.0455249568011133 1.1535894658201016 1.0619378907623278 1.144653775590048 1.0566409908639267 0.9415730862060949 1.0240894023864129 1.107689808553669 1.0 17.50944074118982 -7.005115644444489 24.965045021901343 1.017311452880521 1.08595009781514 0.24170662652572805 0.05456905002851066 317.9858049891309 1551820.778419818 0.02003584301269801 0.017195951769109475 9.882898966222603e-08 7.005115644444489 0.06863864493461902 DSQDASAEQS(ph)DHDDEVASLASASGGFGTK ddPTM_A459_Selumetinib_30min_R1 5 DSQDASAEQSDHDDEVASLASASGGFGTK 29 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 DS(0.019)QDAS(0.387)AEQS(0.594)DHDDEVASLASASGGFGTK;DS(0.053)QDAS(0.433)AEQS(0.514)DHDDEVASLASASGGFGTK;DS(0.008)QDAS(0.154)AEQS(0.838)DHDDEVASLASASGGFGTK;DS(0.001)QDAS(0.099)AEQS(0.898)DHDDEVAS(0.001)LASASGGFGTK;DSQDAS(0.14)AEQS(0.86)DHDDEVASLASASGGFGTK 128.03 7.5941e-14 652073000.0 14958.29 16477.190000000002 17623.5 18557.32 17198.43 14894.630000000001 16077.980000000001 15047.439999999999 8073.570000000001 12475.25 True False 15306.789053234374 14548.032934762183 15230.32549895611 15316.632426039394 15642.83504312944 14744.803545441997 14865.205024144036 14648.333010226354 13700.258619777707 14076.5698567254 1.0873948134403786 1.033492753052444 1.0819628399513448 1.0880940869782652 1.11126753195884 1.047471343908213 1.056024669038377 1.0406180738148918 0.973266836965406 1.0 13.781008204037427 -7.9455867527747 1.5948694252944715 0.9862694624205637 1.074985361823975 0.6958623044378907 0.022318293737752095 0.22984527573528155 1.0587451671811072 0.01979215431656797 0.006800029503487965 1.133478396780548e-08 7.9455867527747 0.0887158994034114 DSQDASAEQS(ph)DHDDEVASLASASGGFGTK ddPTM_A459_Selumetinib_30min_R2 3 DSQDASAEQSDHDDEVASLASASGGFGTK 29 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 DS(0.002)QDAS(0.301)AEQS(0.696)DHDDEVASLASASGGFGTK;DS(0.026)QDAS(0.168)AEQS(0.805)DHDDEVAS(0.002)LASASGGFGTK;DS(0.009)QDAS(0.083)AEQS(0.908)DHDDEVASLASASGGFGTK 99.29 7.0461e-08 223546700.0 347069.0 311610.0 353636.0 413570.0 405934.0 305412.0 330455.0 328766.0 279367.0 344896.0 True False 327780.29440728796 335509.48501592776 330883.4447697637 357241.0525519572 354936.94182399573 347479.730745901 345821.81228416 329722.65462985873 335248.20616617147 334937.95633257454 0.9786298871478769 1.0017063717997543 0.987894738454829 1.0665887391909592 1.0597095226542892 1.0374450675899902 1.0324951405053013 0.98442905139859 1.0009262904598633 1.0 18.35353435095888 -5.676088681663787 24.999999976428356 1.0274568902358348 0.9906390074643439 0.30698945486741935 0.025060120652147605 33.53901706313266 9819.193501115054 0.007576789236041245 0.013123378605427201 2.10819761818663e-06 5.676088681663787 -0.036817882771490895 DSQS(ph)ASGEERPPEADGK ddPTM_A459_Selumetinib_30min_R1 2 DSQSASGEERPPEADGK 17 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 DS(0.001)QS(0.878)AS(0.122)GEERPPEADGK;DS(0.01)QS(0.708)AS(0.283)GEERPPEADGK 155.24 0.00024807 11952200.0 3270.56 4311.1 3104.08 3089.92 3176.53 3317.79 3940.87 3730.7 2020.8799999999999 3819.16 True False 3346.757684598053 3806.3544078239825 2682.5629854909444 2550.323476982001 2889.213422361922 3284.416044912294 3643.60700308736 3631.7497169785356 3429.285760764615 4309.386387768696 0.7766204706306062 0.8832706249380501 0.6224930289622777 0.5918066396228864 0.6704465931767821 0.7621539934860404 0.8455048295109918 0.8427533273151155 0.79577124262933 1.0 12.073266743687421 -7.161497343559948 2.732697459244267 0.8610873405556979 0.707664025246506 0.4150556669818459 0.09052372774232734 0.3373793512506646 4.896196881676791 0.042731004339987576 0.030980560484807143 6.89449810301383e-08 7.161497343559948 -0.15342331530919195 DSQS(ph)ASGEERPPEADGK ddPTM_A459_Selumetinib_30min_R2 1 DSQSASGEERPPEADGK 17 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 DS(0.159)QS(0.681)AS(0.159)GEERPPEADGK 84.37100000000002 0.006770399999999999 15352000.0 36001.0 25190.0 33650.0 37452.0 39292.0 36111.0 36895.0 39625.0 35668.0 31654.0 True False 34000.20854342158 27121.992001383853 31484.995635349824 32350.972991696417 34355.78768506322 41084.96246697981 38610.69060605556 39740.30218972812 42802.59664718805 30740.066773031012 1.1060551297582335 0.8823010113035479 1.0242331569355065 1.0524041222993923 1.1176224156807741 1.3365280814231872 1.2560379549965597 1.292785161566182 1.3924041532902518 1.0 14.907832678378266 -6.465114632746458 2.2835144424061267 1.273824300554113 1.0020867793438886 0.4995552610740318 0.11129504097818745 0.22341126111473503 2.3125908995672746 0.03723188198491374 0.04157274374097176 3.426773243618874e-07 6.465114632746458 -0.27173752121022443 DSS(ph)EEFK ddPTM_A459_Selumetinib_30min_R1 1 DSSEEFK 7 0 Q9P2P6 Q9P2P6 STARD9 StAR-related lipid transfer protein 9 1 DS(0.002)S(0.998)EEFK 100.02 0.020839 7260800.0 36128.0 1034.3 154.52 632.69 1235.3 836.71 1273.0 844.66 358.3 667.14 True False 36969.71210714937 913.2036751669752 133.5370327176042 522.2025685622092 1123.5673331099288 828.2934570718953 1176.9765851018196 822.2568729576457 608.0089308033937 752.7739174939009 49.111308519066625 1.2131181141439777 0.1773932778677685 0.6937043864387613 1.4925694248951342 1.1003216740418034 1.5635193485716856 1.092302554391183 0.807691282433839 1.0 9.556072831451573 -4.761442559830849 9.914560439811366 1.00392430317098 49.318775193743605 0.9993342588734381 0.3724166606138999 0.0017557157999904198 3.550922544758613 0.10038281914635425 0.5683364860828762 1.732038096479593e-05 4.761442559830849 48.31485089057262 DSS(ph)GQEDETQSSNDDPSQSVASQDAQEIIRPR ddPTM_A459_Selumetinib_30min_R2 1 DSSGQEDETQSSNDDPSQSVASQDAQEIIRPR 32 1 Q8N108-17;Q8N108;Q8N108-13;Q8N108-12;Q8N108-19;Q8N108-16;Q8N108-14;Q8N108-18;Q8N108-15 Q8N108-17 MIER1 Mesoderm induction early response protein 1 1 DS(0.157)S(0.549)GQEDET(0.086)QS(0.064)S(0.086)NDDPS(0.057)QS(0.001)VASQDAQEIIRPR 81.876 2.7763e-06 3458700.0 7033.9 10305.0 7485.8 7947.5 7752.6 7180.3 8057.4 7583.3 5399.5 7371.9 True False 6642.983996932666 11095.36036420249 7004.171777922783 6865.036789797797 6778.6490788766405 8169.3211487262915 8432.085065435205 7605.366147517107 6479.550874635295 7159.054092503545 0.9279136476826916 1.5498360846051948 0.9783655336892979 0.958930705243082 0.9468637883285115 1.1411173938859642 1.1778211138626105 1.0623423219389987 0.90508477669141 1.0 12.805553265139809 DSS(ph)GSVSPNTLSQEEGDQICLYHIR ddPTM_A459_Selumetinib_30min_R1 1 DSSGSVSPNTLSQEEGDQICLYHIR 25 0 H7C4T3;H7C4L8;G5E9U9;Q9H0J9 H7C4T3 PARP12 Poly [ADP-ribose] polymerase 12 1 DS(0.105)S(0.435)GS(0.019)VS(0.435)PNT(0.006)LSQEEGDQICLYHIR 186.31 1.3452e-26 17998000.0 2292.3 2616.8 2085.6 2365.1 2714.7 2541.6 2357.3 2089.0 1298.9 2214.4 True False 2345.7061299606535 2310.4238394826857 1802.3869753807628 1952.0796834255038 2469.1558643192134 2516.0338115881627 2179.4869631268825 2033.5929339716831 2204.138432097483 2498.6398100825822 0.938793226816924 0.9246726279472527 0.7213472578591439 0.7812569364933739 0.9882000015991123 1.0069613881262085 0.8722693660495422 0.8138799861291216 0.8821353214670162 1.0 11.28692723024023 -6.256466031641647 24.986845780769087 0.9191724460777451 0.8388735771550847 0.20171274332452427 0.08254724553187197 845.3985694821255 4247407.579102684 0.02737390429127514 0.03424404046081953 5.540308757886313e-07 6.256466031641647 -0.08029886892266036 DSS(ph)PGSSSTSLLIK ddPTM_A459_Selumetinib_30min_R2 1 DSSPGSSSTSLLIK 14 0 H0YG46;J3KNE4;A0A0A0MTP3;Q99550-2;Q99550;U3KQJ0 H0YG46 MPHOSPH9 M-phase phosphoprotein 9 1 DS(0.204)S(0.77)PGS(0.023)S(0.003)S(0.001)T(0.001)SLLIK 145.52 0.00051542 3310100.0 11679.0 12662.0 16287.0 15363.0 16791.0 14319.0 16157.0 15536.0 12655.0 13170.0 True False 11029.927934741267 13633.13468525297 15239.112151944793 13270.53289734678 14681.564466555434 16291.312275059767 16908.33251448812 15581.207187876736 15186.353610243483 12789.74788023056 0.8624038595624319 1.065942410508815 1.1915099730386616 1.037591438206486 1.1479166441778812 1.2737790007762126 1.3220223473383523 1.2182575711254642 1.1873849080103775 1.0 13.642700204713009 -3.9369085889865145 0.7495965852323168 1.20198656099547 5.319908310979029e-15 0.5033864343847018 0.09292470554313673 6.949241308611285 1.1752458043071203 0.036430651207566334 9.437064762596671 0.00011563556082005157 3.9369085889865145 -1.2019865609954647 DSS(ph)PLKDSGACR ddPTM_A459_Selumetinib_30min_R1 2 DSSPLKDSGACR 12 1 A0A087WXL3;O75417-2;O75417 A0A087WXL3 POLQ DNA polymerase theta 1 DS(0.104)S(0.865)PLKDS(0.031)GACR;DS(0.006)S(0.994)PLKDSGACR 135.04 0.0072298 13718200.0 4939.9 5594.5 6876.9 6409.0 4762.2 5687.1 4924.5 4843.6 2780.2 4326.799999999999 True False 5054.990058627857 4939.493339187508 5943.054752107769 5289.788461829967 4331.459850834698 5629.892937473653 4553.041000262306 4715.131993769864 4717.796342226051 4882.186926601032 1.0353946161064198 1.0117378571218234 1.2172935697579508 1.0834874906177971 0.887196642806598 1.1531498121873782 0.9325822769002667 0.9657827659320141 0.9663284944131729 1.0 12.253311817986317 -6.042473846477741 24.53128079957638 0.9880599156734458 1.0921497621054292 0.27375905122254063 0.08183222317062218 519.9939184524484 300327.7376751272 0.02414143208758292 0.031170035779738613 9.06830572921e-07 6.042473846477741 0.10408984643198349 DSS(ph)SGGGDSAAAGASR ddPTM_A459_Selumetinib_30min_R2 1 DSSSGGGDSAAAGASR 16 0 P23378 P23378 GLDC Glycine dehydrogenase (decarboxylating), mitochondrial 1 DSS(0.5)S(0.5)GGGDS(0.001)AAAGASR 211.49 6.4217e-30 0.0 3360.9 2478.0 3080.1 4482.4 3750.8 2614.4 6630.2 5028.6 3773.3 4420.9 True False 3174.1146327486886 2668.054631974165 2881.9297193593143 3871.889387428708 3279.5909714225545 2974.5098688397434 6938.517437492055 5043.232393470457 4528.0654348108865 4293.257130122347 0.739325536893299 0.6214523265458671 0.6712688366925711 0.901853597415063 0.7638934431418727 0.692832918850816 1.616142995212198 1.1746867799010068 1.0546923460607747 1.0 12.067856865377813 -7.2305261489845565 24.92705349410187 1.2259378112460135 0.7331975783312128 0.6610415747845405 0.16811777589431595 384.5681031690969 310099.00219987007 0.06426548828380423 0.04977418238125681 5.8813070157329575e-08 7.2305261489845565 -0.49274023291480074 DSS(ph)TSPGDYVLSVSENSR ddPTM_A459_Selumetinib_30min_R1 4 DSSTSPGDYVLSVSENSR 18 0 P46108-2;I3L297;P46108 P46108-2;P46108 CRK Adapter molecule crk 1 DSS(0.995)T(0.005)SPGDYVLSVSENSR;DSS(0.992)T(0.007)S(0.001)PGDYVLSVSENSR;DSS(0.971)T(0.014)S(0.014)PGDYVLSVSENSR;DSS(0.999)T(0.001)SPGDYVLSVSENSR 351.46 1.0051999999999992e-183 190398000.0 16033.5 16344.800000000001 11503.899999999998 12307.800000000001 14197.100000000002 12726.5 15949.2 15425.9 9571.5 15872.8 True False 16407.049354239898 14431.143217508628 9941.733566399469 10158.473776019788 12912.974811701582 12598.482964737463 14746.139003225415 15016.75502161503 16242.136425299137 17910.22849416492 0.9160714705334579 0.8057486939493953 0.5550869197251418 0.5671883962468361 0.7209832535586342 0.7034239104678088 0.8233361739650417 0.8384457533027805 0.9068637192758741 1.0 14.128496122529148 -7.954551345478723 1.0050914348324027 0.9842680172122231 0.7008469948623448 0.47939208170113146 0.10051076223960066 0.49863184136759353 0.9295725675829652 0.10157246206720394 0.038069350205379875 1.1103212572514456e-08 7.954551345478723 -0.2834210223498783 DSS(ph)TSPGDYVLSVSENSR ddPTM_A459_Selumetinib_30min_R2 3 DSSTSPGDYVLSVSENSR 18 0 P46108-2;I3L297;P46108 P46108-2;P46108 CRK Adapter molecule crk 1 DSS(0.98)T(0.019)SPGDYVLSVSENSR;DSS(0.773)T(0.226)SPGDYVLSVSENSR;DSS(0.481)T(0.481)S(0.039)PGDYVLSVSENSR 384.32 2.9428999999999967e-256 69599000.0 153754.0 116704.0 146362.0 156789.0 163291.0 126299.0 134056.0 143802.0 140143.0 138023.0 True False 145208.96820602883 125654.82153749498 136945.2282668968 135434.06772388885 142776.92473993823 143695.54082182946 140289.86962692472 144220.44001229745 168175.51592258835 134037.9173631788 1.0833424680315034 0.9374572808157737 1.021690212448173 1.0104160851509438 1.065198024176106 1.0720514287944591 1.0466431617764256 1.0759674788256286 1.2546861308424613 1.0 17.032281650147667 -6.90236836962654 0.8833562548141203 1.1129067684483778 1.0064637780150003 0.21602867218181188 0.06943092222530943 0.8226973361806368 1.3623332657734484 0.04525139998532664 0.03648623017002153 1.25207870823289e-07 6.90236836962654 -0.10644299043337746 DSS(ph)VEVR ddPTM_A459_Selumetinib_30min_R2 2 DSSVEVR 7 0 O15371-2;O15371-3;O15371;B0QYA6;B0QYA5 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 DS(0.007)S(0.993)VEVR;DS(0.024)S(0.976)VEVR 158.07 0.0011366 56322000.0 219819.0 169588.0 166087.0 205846.0 214779.0 176260.0 230317.0 305087.0 177866.0 298608.0 True False 207602.33998517765 182594.85428863365 155401.14324185275 177809.41969584354 187796.54187137794 200538.2150710269 241027.1968644776 305974.75266012794 213444.169991274 289986.4111632418 0.7159036837361054 0.6296669335510542 0.5358911219959647 0.6131646616908178 0.6476046278101694 0.6915434908366728 0.83116721193117 1.0551347955676649 0.7360488691006974 1.0 18.14562577120553 -7.268393343751568 2.313876691391265 0.9251795754981634 0.6244104723554994 0.6975528928096546 0.08804532588940746 0.16717424160334385 1.7558053802189315 0.041043361978494466 0.026763179339462217 5.39022204935333e-08 7.268393343751568 -0.30076910314266403 DSSDS(ph)ADGRATPSENLVPSSAR ddPTM_A459_Selumetinib_30min_R1 1 DSSDSADGRATPSENLVPSSAR 22 1 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 DS(0.001)S(0.004)DS(0.581)ADGRAT(0.406)PS(0.008)ENLVPSSAR 101.42 6.5237e-05 64077000.0 4672.5 5952.1 6759.8 6738.0 5491.4 5987.7 5328.9 4915.8 3305.5 3898.1 True False 4781.360158897679 5255.225364943782 5841.856288923512 5561.33478792484 4994.703839585413 5927.469174396612 4926.9367826779935 4785.417015231212 5609.192075832033 4398.459105709409 1.0870534530356883 1.1947878196985506 1.3281597369725466 1.2643825153918022 1.1355576395156317 1.3476240274014313 1.1201506400917982 1.0879757888437596 1.2752629821091288 1.0 12.10278248343464 -10.745685617069816 0.36921561518126306 0.8880624663489294 1.2195765743884013 0.29948787373659036 0.09220315849902135 23.66870577648076 2.0944727059374024 2.7297341660844348 0.069230246617438 1.7960332931000487e-11 10.745685617069816 0.3315141080394719 DSSDS(ph)ADGRATPSENLVPSSAR ddPTM_A459_Selumetinib_30min_R2 1 DSSDSADGRATPSENLVPSSAR 22 1 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 DS(0.003)S(0.02)DS(0.61)ADGRAT(0.353)PS(0.012)ENLVPS(0.001)S(0.001)AR 58.082 0.010981 13964000.0 17108.0 19147.0 20027.0 19294.0 18804.0 14128.0 17037.0 12421.0 12767.0 18194.0 True False 16157.20584875021 20615.5133326914 18738.48462374892 16666.12391599355 16441.6734101071 16074.003758785142 17829.25425817505 12457.143053592754 15320.75673978495 17668.691946310926 0.9144539900206761 1.1667820909060416 1.0605473614395862 0.9432573710966361 0.9305540817660802 0.9097449775924843 1.0090873909824234 0.7050404801581082 0.8671132411125542 1.0 14.108907617377705 -5.930384855188522 2.446735854110551 0.8942005063922986 1.0602277247608123 0.29529531907284123 0.09767627832661717 0.3317658544057185 4.025110717309947 0.03023765259922545 0.048620202897144714 1.1738568667610378e-06 5.930384855188522 0.16602721836851364 DSSDSADGRAT(ph)PSENLVPSSAR ddPTM_A459_Selumetinib_30min_R1 2 DSSDSADGRATPSENLVPSSAR 22 1 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 DS(0.026)S(0.101)DS(0.376)ADGRAT(0.495)PS(0.003)ENLVPSSAR;DSS(0.001)DS(0.055)ADGRAT(0.933)PS(0.011)ENLVPSSAR 163.96 9.793299999999998e-09 29139000.0 1992.15 2476.3999999999996 2732.9 2646.3 2899.34 2167.08 2165.2 2142.32 1527.73 1983.44 True False 2038.5632189508854 2186.4619367528744 2361.787190745151 2184.1733822032515 2637.0952089200523 2145.281142751209 2001.8772207874797 2085.498714363914 2592.4462290155416 2238.0338443416726 0.9108723820709412 0.9769566006701885 1.055295565219605 0.9759340269698806 1.1783089051969924 0.9585561666884678 0.8944803162153879 0.9318441361539699 1.1583588137283602 1.0 11.12801613808752 -4.875887011180341 3.3991231260785977 1.0143869436544446 0.9070975613577005 0.12657435633398006 0.086827465944285 0.6160996105396677 12.045180210844773 0.02268855086519475 0.14922866137219004 1.3308006025077254e-05 4.875887011180341 -0.10728938229674412 DSSDSADGRAT(ph)PSENLVPSSAR ddPTM_A459_Selumetinib_30min_R2 2 DSSDSADGRATPSENLVPSSAR 22 1 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 DS(0.072)S(0.064)DS(0.32)ADGRAT(0.533)PS(0.012)ENLVPSSAR;DS(0.003)S(0.038)DS(0.133)ADGRAT(0.778)PS(0.047)ENLVPSSAR 62.19300000000001 0.015879 55711000.0 79814.0 87383.0 78120.0 85762.0 98069.0 63644.0 59817.0 55443.0 51784.0 82384.0 True False 75378.25740075698 94084.99511936995 73093.84425062491 74081.06765229806 85748.69547201622 72410.38329729064 62598.60902513689 55604.32995091722 62142.24696585131 80005.35986066167 0.9421650940891546 1.1759836501358103 0.9136118427306128 0.9259513085288107 1.0717868855456336 0.9050691531592566 0.7824301913541718 0.6950075600904541 0.7767260477807864 1.0 16.28780903436659 -7.049218389889829 3.5469722898529543 0.7896467947372477 1.005594703495859 0.42769226682224737 0.10312405927253183 0.20759281533496013 5.278338042831178 0.04012930327762049 0.03166217175486516 8.928563878981004e-08 7.049218389889829 0.21594790875861125 DSSEATGWEEPS(ph)PPSIR ddPTM_A459_Selumetinib_30min_R1 2 DSSEATGWEEPSPPSIR 17 0 A0A1B0GU24;Q9HCJ0;Q9HCJ0-2 A0A1B0GU24 TNRC6C Trinucleotide repeat-containing gene 6C protein 1 DSSEATGWEEPS(0.975)PPS(0.025)IR;DSSEATGWEEPS(0.792)PPS(0.208)IR 163.34 1.1393e-05 9338400.0 1888.06 2018.3600000000001 1839.6999999999998 2066.41 1854.84 1779.66 2087.04 2066.31 1177.92 2061.05 True False 1932.0481244747684 1782.0494728898925 1589.8788447487482 1705.5502848197941 1687.0700494986002 1761.7582362019928 1929.612892514457 2011.5047464791903 1998.8442081270812 2325.6058438270893 0.8307719597467685 0.7662732176305923 0.683640716232633 0.7333789125732018 0.7254324949245506 0.7575480775808461 0.8297248210122425 0.8649379480269088 0.859493973767163 1.0 11.183390886485274 -8.232152574260937 0.7114356877014859 0.9925380618402594 0.741573596828121 0.7872051466174239 0.0401626755416943 0.304181346019176 0.34268024641168804 0.04149309694771749 0.017414355911737303 5.859322814235601e-09 8.232152574260937 -0.2509644650121384 DSSEATGWEEPS(ph)PPSIR ddPTM_A459_Selumetinib_30min_R2 2 DSSEATGWEEPSPPSIR 17 0 A0A1B0GU24;Q9HCJ0;Q9HCJ0-2 A0A1B0GU24 TNRC6C Trinucleotide repeat-containing gene 6C protein 1 DSSEATGWEEPS(0.997)PPS(0.003)IR;DSSEATGWEEPS(1)PPSIR 160.93 3.9118e-05 3918800.0 12467.4 11717.6 13928.099999999999 12816.400000000001 15303.7 10632.9 11295.5 9006.3 10120.2 11550.099999999999 True False 11774.511818956538 12616.302241977583 13031.98120976867 11070.78421047682 13381.112389186139 12097.485459144014 11820.763131608635 9032.506841926775 12144.522782013924 11216.61860223622 1.049738092780394 1.1247865947284963 1.1618457996931917 0.986998364040806 1.1929720411923779 1.0785322999867517 1.0538615558571252 0.8052789492303852 1.082725838568917 1.0 13.453350201571997 -7.536842957538957 24.997471014396865 0.9523154430554603 1.099317356556414 0.34622412122809065 0.08350795473898102 233.28645212239343 417603.2416074382 0.03671258555839608 0.02120770460328243 2.9050729494810273e-08 7.536842957538957 0.1470019135009537 DSSFTEVPRS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DSSFTEVPRSPK 12 1 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 DSSFTEVPRS(1)PK;DSSFTEVPRS(1)PK 134.06 0.0078503 41952000.0 140166.0 122585.0 108310.0 89705.0 114720.0 69549.0 98653.0 97092.0 64147.0 97660.0 True False 132376.13484895483 131986.8753270995 101341.45251901138 77487.02425024373 100307.84799018758 79128.74344703768 103240.55997721085 97374.52164555412 76978.19241693318 94840.30204884727 1.3957793468516666 1.3916749786300762 1.0685483948249734 0.8170263334920025 1.0576500266576996 0.8343366874378216 1.0885726610617188 1.026720914442065 0.8116611899578909 1.0 16.53321263709396 -5.341735216535979 3.477684814285176 0.9540964631901382 1.4016459819725449 0.7707626580069484 0.09561658384442895 0.10095854311130542 2.326571236854882 0.024733798500480946 0.060169610064999275 4.552655447891936e-06 5.341735216535979 0.4475495187824067 DSSGS(ph)FSPCQPFLEK ddPTM_A459_Selumetinib_30min_R2 1 DSSGSFSPCQPFLEK 15 0 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 DS(0.036)S(0.079)GS(0.862)FS(0.023)PCQPFLEK 158.14 0.00014873 2857600.0 14471.0 17821.0 14803.0 15019.0 18743.0 13065.0 12724.0 14131.0 12885.0 14794.0 True False 13666.759752002823 19187.81339645341 13850.591096287768 12973.386290779885 16388.33677545402 14864.585157738382 13315.691212127686 14172.118870487015 15462.36003698043 14366.85878057183 0.9512698607773785 1.3355607993029701 0.9640653748902852 0.9030078522330626 1.1407042434088526 1.0346440641457144 0.9268338622590465 0.986445199117001 1.0762519680286713 1.0 13.810457040016807 DSSGSFS(ph)PCQPFLEK ddPTM_A459_Selumetinib_30min_R1 1 DSSGSFSPCQPFLEK 15 0 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 DSSGS(0.001)FS(0.999)PCQPFLEK 164.41 8.696900000000001e-06 0.0 864.76 996.98 980.8 1071.1 1016.1 814.37 754.7 679.05 511.51 794.0 True False 884.9072254699535 880.253118116572 847.6127471487591 884.0524920371466 924.1939344070258 806.1781771887985 697.772371387544 661.0393881347399 867.9951107877305 895.9176342149432 0.987710467654052 0.9825156738743094 0.9460833393367554 0.9867564363902788 1.0315612720547243 0.8998351482334871 0.7788354026528053 0.7378350005511191 0.9688336043840904 1.0 9.807222294633826 -6.958146839233727 5.855427447119693 0.8479560827865151 0.9835860421247326 0.328004958673193 0.0764347846514959 0.18386833028660404 15.749212107076602 0.026878516004542212 0.023392267174609068 1.1011669312279469e-07 6.958146839233727 0.13562995933821742 DSSGSVS(ph)PNTLSQEEGDQICLYHIR ddPTM_A459_Selumetinib_30min_R1 1 DSSGSVSPNTLSQEEGDQICLYHIR 25 0 H7C4T3;H7C4L8;G5E9U9;Q9H0J9 H7C4T3 PARP12 Poly [ADP-ribose] polymerase 12 1 DS(0.007)S(0.031)GS(0.023)VS(0.938)PNT(0.001)LSQEEGDQICLYHIR 210.23 2.657e-32 14981000.0 2652.8 3190.9 2639.0 2489.0 2899.0 2755.2 2932.7 2547.0 1556.9 2142.7 True False 2714.6050785497637 2817.3079445908356 2280.6382949893714 2054.3428743165514 2636.7859618600214 2727.485189521444 2711.4840778696835 2479.445286178017 2641.9455885230345 2417.736416665441 1.1227878522398094 1.1652667863920776 0.9432948435854904 0.8496967908312831 1.090601086075667 1.1281151951556452 1.121496975095979 1.025523406557976 1.092735159346619 1.0 11.239441254188103 DSSGSVS(ph)PNTLSQEEGDQICLYHIR ddPTM_A459_Selumetinib_30min_R2 1 DSSGSVSPNTLSQEEGDQICLYHIR 25 0 H7C4T3;H7C4L8;G5E9U9;Q9H0J9 H7C4T3 PARP12 Poly [ADP-ribose] polymerase 12 1 DS(0.003)S(0.013)GS(0.05)VS(0.788)PNT(0.145)LSQEEGDQICLYHIR 142.21 9.1828e-09 3772300.0 15652.0 15181.0 19964.0 20224.0 19824.0 14193.0 17718.0 14787.0 15626.0 18495.0 True False 14782.124499920403 16345.333885391352 18679.537975159703 17469.456311654056 17333.53189119142 16147.956918773896 18541.922107550956 14830.027721880379 18751.636626919368 17961.001294219 0.823012272967111 0.9100458052220244 1.0400053799434876 0.9726326514589609 0.9650648985126713 0.8990566090528228 1.032343453675878 0.8256793415327925 1.0440195576933031 1.0 14.13258015958049 -4.905273441682442 3.784671384388233 0.9659898815793085 0.8240120264011087 0.33622911598574623 0.06452227300820017 0.2669883578936135 6.73674833669745 0.015391030811577402 0.084326939346028 1.2437312836957817e-05 4.905273441682442 -0.14197785517819983 DSSGSVSPNT(ph)LSQEEGDQICLYHIR ddPTM_A459_Selumetinib_30min_R2 2 DSSGSVSPNTLSQEEGDQICLYHIR 25 0 H7C4T3;H7C4L8;G5E9U9;Q9H0J9 H7C4T3 PARP12 Poly [ADP-ribose] polymerase 12 1 DS(0.009)S(0.033)GS(0.026)VS(0.414)PNT(0.518)LS(0.001)QEEGDQICLYHIR;DS(0.04)S(0.04)GS(0.009)VS(0.371)PNT(0.531)LS(0.01)QEEGDQICLYHIR 124.73 1.0397e-07 14565000.0 33221.0 26993.0 35014.0 35057.0 43417.0 27948.0 29255.0 33813.0 23270.0 27540.0 True False 31374.709814199836 29063.276303825085 32761.237360360734 30282.17612330186 37962.568307095295 31797.58331331592 30615.41546768276 33911.3902319565 27924.650218124523 26744.848642486704 1.1731122592467456 1.086686886597494 1.2249550482898015 1.1322620115784008 1.4194347784338621 1.1889236592202086 1.1447219566255946 1.2679596989038506 1.0441132268650641 1.0 14.70697341859146 -8.390000518398088 4.970970849998829 1.0030996136509072 1.203340417730601 0.41908959236786436 0.08654009134557565 0.21654426151021383 7.283056655334935 0.0844410556467126 0.022026779088637972 4.073797915326087e-09 8.390000518398088 0.2002408040796939 DSSKGEDS(ph)AEETEAK ddPTM_A459_Selumetinib_30min_R1 1 DSSKGEDSAEETEAK 15 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 DS(0.001)S(0.002)KGEDS(0.997)AEETEAK 141.6 0.0018266 7333100.0 1061.7 1454.7 858.17 1064.5 727.77 1139.2 972.53 1353.0 634.35 1273.6 True False 1086.4355442914211 1284.3830477283177 741.6352275903853 878.6050581398034 661.9433319982295 1127.7406823108406 899.1712791116051 1317.1140448366139 1076.4456189091063 1437.0789659145487 0.756002676303887 0.8937456313758958 0.5160713121414403 0.6113825885557126 0.4606172296015568 0.7847451038246552 0.6256937165170863 0.9165216916235429 0.7490511269323761 1.0 10.488923623147155 -8.241276509338668 0.911729988015419 0.9758163478210128 0.6575235697910069 0.3536947934204524 0.13495568240753492 0.6201306570513722 1.0771365408149998 0.13147673829374693 0.0476731069712229 5.737510464719137e-09 8.241276509338668 -0.3182927780300059 DSSKGEDS(ph)AEETEAK ddPTM_A459_Selumetinib_30min_R2 1 DSSKGEDSAEETEAK 15 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 DS(0.005)S(0.031)KGEDS(0.956)AEET(0.009)EAK 121.26 0.0084616 0.0 13002.0 8244.5 10760.0 9469.7 10675.0 10222.0 13369.0 13852.0 9413.8 8769.8 True False 12279.400891129893 8876.82663975424 10067.713314602204 8179.910523856332 9333.911064289163 11629.987713922837 13990.68499017093 13892.307026677949 11296.823043548802 8516.593087323163 1.4418207803549545 1.042297847124724 1.1821291931380242 0.9604674592275662 1.0959677148580185 1.3655680851106908 1.6427560700294441 1.6312047416421087 1.3264486077612392 1.0 13.05606070584099 -6.874767952099634 4.555200777694991 1.458663930304554 1.1314248585861821 0.24501975131863285 0.2074119273863668 0.2392410578859345 8.450710556036592 0.07279143421508928 0.06418957803455524 1.3342341364336407e-07 6.874767952099634 -0.32723907171837197 DSSLCVSGETLAAGTS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 DSSLCVSGETLAAGTSSPK 19 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 DSSLCVSGETLAAGT(0.003)S(0.653)S(0.344)PK 119.96 0.00043976 4059200.0 25662.0 20636.0 21297.0 23784.0 20635.0 20566.0 31119.0 25439.0 21955.0 20844.0 True False 24235.808773125314 22218.714844801794 19926.774206420352 20544.578170311517 18042.646820759408 23398.779820439933 32566.095161128687 25513.023278346853 26346.61347395461 20242.179560784058 1.1972924506646638 1.09764439042162 0.9844184094199643 1.0149390340412408 0.891339135026453 1.1559417181424116 1.6088235490322504 1.2603891395062121 1.3015699912571126 1.0 14.305077019000683 -7.005810011105411 24.676327031507228 1.3241073270155943 1.0350591199852481 0.366054789121958 0.15637714941388386 207.79583016805807 882554.7891468174 0.054780331310770466 0.04680066884401135 9.867110433636703e-08 7.005810011105411 -0.28904820703034617 DSSLCVSGETLAAGTSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DSSLCVSGETLAAGTSSPK 19 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 DSSLCVSGETLAAGTS(0.058)S(0.942)PK 91.592 0.0024379 4360000.0 1444.6 2073.1 1665.0 1443.1 1497.8 1558.8 1638.5 2109.5 1175.1 2081.1 True False 1478.2563692977183 1830.3804882419577 1438.9021451903382 1191.0896753419918 1362.3242544580685 1543.1198872771583 1514.9066258360829 2053.549207378299 1994.0588740917315 2348.2294566306277 0.6295195578624604 0.7794725864942904 0.6127604528285563 0.5072288280767223 0.5801495465493429 0.6571418661493642 0.6451271708386439 0.8745096019384951 0.8491754791939795 1.0 11.197357672568755 -7.926414174726425 1.4232115758478612 0.9595441150337808 0.6220906934707799 0.7532586196242275 0.07302937143416775 0.22552989733552178 0.8237436273608691 0.06868416753039584 0.023987378586663693 1.1846384521120736e-08 7.926414174726425 -0.33745342156300084 DSSPSSSPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 DSSPSSSPSPK 11 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 DSSPS(0.001)S(0.007)S(0.05)PS(0.942)PK;DSS(0.001)PS(0.017)S(0.072)S(0.05)PS(0.859)PK 138.89 0.0012132 14784000.0 7609.099999999999 7443.700000000001 7803.0 7007.8 5776.5 8064.5 6346.6 7796.4 5883.8 7074.2 True False 7786.377225268772 6572.188143517755 6743.395458810938 5784.019282698084 5254.016594923904 7983.378451980137 5867.870852323028 7589.614145723711 9984.378864250644 7982.242478543263 0.9754623774207576 0.8233511022979048 0.8447996257865608 0.7246108218643905 0.658213103529116 1.0001423125694222 0.7351155853879671 0.9508122768914925 1.2508237993382487 1.0 12.962578389279063 -8.021249159322835 5.572912664196024 1.1218280568952408 0.821397722237751 0.5250135801496473 0.11461732480239623 0.13278597300853426 13.076242435165469 0.07290438771020388 0.029159682729106403 9.52249691592946e-09 8.021249159322835 -0.3004303346574898 DSSS(ph)LSSCTSGILEER ddPTM_A459_Selumetinib_30min_R1 1 DSSSLSSCTSGILEER 16 0 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 DSS(0.029)S(0.641)LS(0.319)S(0.01)CT(0.001)SGILEER 134.76 0.00042515 9561000.0 2443.3 2957.3 2800.0 2757.3 2517.5 2525.7 2795.5 2511.1 1663.4 2367.6 True False 2500.2241361658016 2611.057941188529 2419.775379299067 2275.7893159313085 2289.7925695007257 2500.2937511521163 2584.6331843300363 2444.4974707976517 2822.6683100707914 2671.504522376953 0.9358861702173891 0.9773735808110697 0.9057725184556634 0.85187552439793 0.8571172349966296 0.9359122285623147 0.9674822418157003 0.9150265142065628 1.056583766348762 1.0 11.383436744048222 -8.253105800287265 24.49158111911294 1.0282918851806326 0.9178290410069978 0.5404859343284789 0.04056343308472697 347.8595710799012 1022335.1426113381 0.03173583080573398 0.011533609997246612 5.583341600577181e-09 8.253105800287265 -0.11046284417363483 DSSS(ph)SLTDPQVSYVK ddPTM_A459_Selumetinib_30min_R1 1 DSSSSLTDPQVSYVK 15 0 O94887-3;O94887-2;O94887;H7C3M7 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 1 DSS(0.001)S(0.5)S(0.5)LTDPQVSYVK 241.27 2.016099999999999e-65 0.0 1388.7 1447.2 1465.3 1471.4 1465.5 1261.1 1414.1 1669.3 691.21 1109.8 True False 1421.0540080601834 1277.7611512149729 1266.3203083167573 1214.4476115987839 1332.945783755039 1248.414478987185 1307.4332985015583 1625.0247413494167 1172.9328860190174 1252.2536403674364 1.1347972665052246 1.0203692846443249 1.0112330820976438 0.9698096076146686 1.0644375394779653 0.9969341982674333 1.044064282470707 1.2976801895122474 0.9366575973177887 1.0 10.290311090254638 -7.547176873800748 24.99924168695073 1.1044757164243326 1.0291495220459315 0.02012604470648205 0.09683485883265466 509.68655513976375 524386.5365641284 0.04279726917846514 0.024710341167756465 2.8367634730637794e-08 7.547176873800748 -0.07532619437840116 DSSS(ph)SLTDPQVSYVK ddPTM_A459_Selumetinib_30min_R2 1 DSSSSLTDPQVSYVK 15 0 O94887-3;O94887-2;O94887;H7C3M7 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 1 DSSS(0.931)S(0.068)LTDPQVSYVK 290.63 3.1655999999999985e-67 6459000.0 75715.0 61462.0 68343.0 77020.0 71202.0 64111.0 77033.0 80324.0 65998.0 57855.0 True False 71507.06341115986 66175.93776852141 63945.885786232146 66529.7431330893 62256.968206043704 72941.70830828678 80615.18713799378 80557.72954164603 79199.44413819446 56184.57582465748 1.2727169754617578 1.1778310469949134 1.1381395133389705 1.1841282443907264 1.108079349043003 1.2982514727160255 1.4348277254878652 1.4338050676586582 1.4096296532586183 1.0 15.777886505806412 -6.936454530275625 5.652450832649444 1.3573413351244257 1.1755172876714919 0.2136594501580007 0.12565457031259922 0.23341123154867421 14.427570334454277 0.04263821298083233 0.037336228731365974 1.1575652204067649e-07 6.936454530275625 -0.1818240474529338 DSSSLSSCTSGILEERS(ph)PAFR ddPTM_A459_Selumetinib_30min_R1 2 DSSSLSSCTSGILEERSPAFR 21 1 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 DSSSLSSCTSGILEERS(1)PAFR;DSSSLSSCTSGILEERS(1)PAFR 166.93 1.939e-10 59877000.0 2266.02 3566.3999999999996 3254.3 3091.2 3030.2599999999998 2748.85 3438.3 3279.3 1634.54 2717.0 True False 2318.813857092631 3148.8442300256206 2812.38393459034 2551.3799490105757 2756.1735180358564 2721.199064756104 3178.946262808789 3192.32231133238 2773.6949979217925 3065.7534158211593 0.7563601968527984 1.027102901941057 0.9173549053478084 0.8322195568123312 0.8990199615573511 0.8876118512053368 1.0369217062283893 1.0412847604957556 0.9047351895973867 1.0 11.582025947712843 -7.2499361687381345 24.044079394274004 0.9991758097908194 0.8924866024603624 0.34792183109898955 0.0728605334402011 515.6422381117087 1077800.0342500862 0.027520829982617488 0.02110677243473235 5.624239824560432e-08 7.2499361687381345 -0.10668920733045706 DSSSLSSCTSGILEERS(ph)PAFR ddPTM_A459_Selumetinib_30min_R2 4 DSSSLSSCTSGILEERSPAFR 21 1 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 DSSSLSSCTSGILEERS(1)PAFR;DSSSLSSCTSGILEERS(1)PAFR;DSSSLSSCTSGILEERS(1)PAFR;DSSSLSS(0.001)CT(0.001)S(0.001)GILEERS(0.998)PAFR 110.34 6.0477e-05 36078500.0 59877.2 52897.4 49127.0 51815.4 56525.5 43777.4 39923.1 43834.5 34961.6 53684.0 True False 56549.464931423034 56954.4604880509 45966.22230543329 44758.05313344936 49424.26134561841 49807.33947832962 41779.60325612187 43962.05113780788 41954.89690872293 52134.003432216974 1.0846944644285166 1.0924628215460441 0.8816936985320369 0.858519395918681 0.948023518084091 0.955371469660633 0.8013887387421229 0.8432510116927043 0.8047511057398726 1.0 15.669937030007787 -5.262113913272516 24.5823981841124 0.8816268138887268 1.0885786654784688 0.629780606030649 0.061841624062791596 27.87464712243906 1015916.8059551204 0.016446088236881075 0.037873487107245876 5.4687250215558e-06 5.262113913272516 0.20695185158974205 DSSSLSSCTSGILEERS(ph)PAFRGPDR ddPTM_A459_Selumetinib_30min_R1 2 DSSSLSSCTSGILEERSPAFRGPDR 25 2 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 DSSSLS(0.001)S(0.008)CT(0.007)S(0.005)GILEERS(0.978)PAFRGPDR;DSSSLSSCTS(0.001)GILEERS(0.999)PAFRGPDR 77.28699999999998 0.00010359 32594000.0 2208.27 1773.07 4514.7 4913.7 3604.0 2462.6 2580.12 2739.12 1772.78 1678.4099999999999 True False 2259.7183944545704 1565.4781401221192 3901.6285374719628 4055.614536572616 3278.018836337878 2437.8284798619 2385.4994711334707 2666.469639684308 3008.278181271672 1893.8502725978622 1.1931874589826121 0.8266113550648841 2.060156810664847 2.141465244245198 1.7308753937771977 1.2872340095385912 1.2596029927229653 1.4079622229198805 1.5884456257173432 1.0 10.887106560811988 -6.772379132477033 24.637637561078847 1.3310811848833093 1.6047290135894918 0.11676804498368232 0.38406255038393444 492.65715169708284 1109515.6207513318 0.1505158853303063 0.13404644965668924 1.6889658463789197e-07 6.772379132477033 0.27364782870618254 DSSSLSSCTSGILEERS(ph)PAFRGPDR ddPTM_A459_Selumetinib_30min_R2 1 DSSSLSSCTSGILEERSPAFRGPDR 25 2 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 DSSSLSS(0.001)CT(0.004)S(0.034)GILEERS(0.961)PAFRGPDR 57.985 0.0038662 6009700.0 17701.0 31381.0 26481.0 33238.0 24823.0 17745.0 15407.0 15153.0 13227.0 27314.0 True False 16717.249282717297 33787.8217941813 24777.241290332782 28710.92706125188 21704.512819564377 20189.212676928255 16123.456028391327 15197.092721285802 15872.76959325884 26525.373849705215 0.630236142096941 1.2737924820824644 0.9340958370925332 1.0823948127528824 0.8182547376162839 0.7611282989382872 0.6078502840241972 0.5729266176376508 0.5983994677396504 1.0 14.695085464235763 -6.622258319863626 2.1424983521951986 0.6655751276427915 0.9971318345068727 0.3014498247271018 0.1895261102223135 0.32004721996158514 2.9966793062185118 0.06745824930707944 0.06809303999659197 2.3863914267925926e-07 6.622258319863626 0.33155670686408123 DSSSS(ph)LTDPQVSYVK ddPTM_A459_Selumetinib_30min_R2 1 DSSSSLTDPQVSYVK 15 0 O94887-3;O94887-2;O94887;H7C3M7 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 1 DSSS(0.018)S(0.982)LTDPQVSYVK 357.92 4.731399999999995e-189 6088400.0 96337.0 76938.0 89509.0 103820.0 87934.0 75637.0 102890.0 103630.0 86662.0 74247.0 True False 90982.97520756647 82838.89720533833 83750.08839003036 89679.53690051053 76886.94478006582 86055.31018567621 107674.58887266708 103931.54614312988 103996.82153859499 72103.2961931268 1.2618421072439039 1.1488919588843278 1.1615292616541126 1.2437647324791676 1.066344381456933 1.1935003630788155 1.4933379548178145 1.4414257271228204 1.4423310310258524 1.0 16.137777593145643 -7.1604929224253 7.22661584765034 1.3805139732363412 1.173600011302521 0.24013568147391495 0.13790474050904392 0.29452849878074233 18.41635317702485 0.0497864101900186 0.03850805296554038 6.910461910980758e-08 7.1604929224253 -0.20691396193382028 DSSSSLTDPQVSYVKS(ph)PAAER ddPTM_A459_Selumetinib_30min_R1 2 DSSSSLTDPQVSYVKSPAAER 21 1 O94887-3;O94887-2;O94887;H7C3M7 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 1 DSSSSLTDPQVSYVKS(1)PAAER;DSSSSLTDPQVS(0.001)YVKS(0.999)PAAER 169.1 1.4431e-10 120203000.0 14696.7 13278.2 17292.6 18036.7 16497.4 14412.199999999999 13720.2 13667.3 7906.8 10673.5 True False 15039.104515199908 11723.582171132297 14944.35990145252 14886.928935791622 15005.213082852528 14267.226353230595 12685.274267803614 13304.798806352885 13417.262110176587 12043.5476936942 1.248727110789301 0.9734326188013993 1.2408602748571451 1.2360916662111257 1.2459130369624398 1.1846365137658463 1.053283848781984 1.1047242178746928 1.1140622722988545 1.0 13.555972812027438 -7.252867548082915 23.200075139303028 1.0767446020462488 1.185694617352244 0.33950923481724093 0.08176451062233937 319.6005928640913 865017.1508143786 0.03247257309430571 0.024696098320397458 5.586405439629382e-08 7.252867548082915 0.10895001530599524 DSSSSLTDPQVSYVKS(ph)PAAER ddPTM_A459_Selumetinib_30min_R2 2 DSSSSLTDPQVSYVKSPAAER 21 1 O94887-3;O94887-2;O94887;H7C3M7 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 1 DSSSSLTDPQVS(0.02)Y(0.006)VKS(0.974)PAAER;DSSS(0.001)S(0.001)LT(0.003)DPQVS(0.21)Y(0.038)VKS(0.748)PAAER 109.42 6.4268e-05 75624000.0 250409.0 250225.0 239269.0 265565.0 234964.0 169010.0 183999.0 162239.0 125236.0 240022.0 True False 236492.27024665003 269416.4528998128 223874.69303638983 229394.58887482234 205445.72171518847 192289.5933799742 192555.31808710186 162711.08862988788 150286.69938620736 233091.94120795027 1.0145879305010643 1.1558376986506627 0.9604565986975183 0.9841377942370415 0.8813934992797647 0.8249517009617474 0.8260917005076374 0.6980554016010664 0.6447528756566098 1.0 17.830539600824203 -6.265697059682343 0.9255866760749906 0.7649384444543387 1.0809115794083102 0.5625821528132839 0.09735522869193698 0.3925132970193068 0.716879295338576 0.046304804391604254 0.07406126540147685 5.423790927699839e-07 6.265697059682343 0.3159731349539715 DSSST(ph)DSANEKPALIPR ddPTM_A459_Selumetinib_30min_R1 1 DSSSTDSANEKPALIPR 17 1 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3;F2Z2S1;C9JKE4;F8VZ02;F8VT91;C9JGM8;F8W6C2;C9JW67 B8ZZZ7;C9JW67 SPATS2L SPATS2-like protein 1 DS(0.002)S(0.012)S(0.055)T(0.558)DS(0.373)ANEKPALIPR 113.37 0.0025259 14848000.0 1195.7 1890.5 1685.3 1653.5 1798.8 1804.7 1582.5 1679.0 757.2 1627.1 True False 1223.5574835728112 1669.1593811303946 1456.4455166902562 1364.7472650391403 1636.0988576039344 1786.5463565364944 1463.1307509219403 1634.4674658393758 1284.9130963001114 1835.9541342961384 0.6664422932558141 0.909150915020168 0.7932907960408407 0.7433449668187666 0.8911436440819238 0.9730887733867133 0.7969320821202704 0.8902550642780585 0.6998612178254208 1.0 10.842314302536884 -6.272467959234049 24.447324203414272 0.8707059157208729 0.7885091863771362 0.1900811580529247 0.09702937535090443 1075.5960312056093 2384294.075804354 0.029293629830355647 0.03354143584085077 5.339886679840133e-07 6.272467959234049 -0.08219672934373667 DSSSTDS(ph)ANEKPALIPR ddPTM_A459_Selumetinib_30min_R2 1 DSSSTDSANEKPALIPR 17 1 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3;F2Z2S1;C9JKE4;F8VZ02;F8VT91;C9JGM8;F8W6C2;C9JW67 B8ZZZ7;C9JW67 SPATS2L SPATS2-like protein 1 DS(0.152)S(0.257)S(0.257)T(0.027)DS(0.308)ANEKPALIPR 211.45 1.3265e-08 4613700.0 36833.0 29716.0 39691.0 38634.0 40038.0 33485.0 32455.0 35723.0 25708.0 32344.0 True False 34785.96931418146 31995.12164800011 37137.32427229329 33371.98255263268 35008.068495738575 38097.254803434334 33964.22180836244 35826.94801573899 30850.31834153611 31410.14468019569 1.107475615548955 1.0186238227731963 1.1823353458065613 1.0624587340304084 1.114546553420093 1.2128965081607825 1.0813137651599902 1.1406170961806528 0.9821768939825178 1.0 14.938942967840827 -8.266348850757126 24.939343664007996 0.9910884253207048 1.1144325692167574 0.46588471510552465 0.05308131546619757 369.4202849111306 1876561.565254739 0.04519732840911043 0.013130628487886929 5.415656983599192e-09 8.266348850757126 0.12334414389605253 DSSVPGS(ph)PSSIVAK ddPTM_A459_Selumetinib_30min_R1 2 DSSVPGSPSSIVAK 14 0 Q08495;Q08495-2;E5RGQ0;E5RJ61;A0A087WT94 Q08495 DMTN Dematin 1 DSSVPGS(0.99)PS(0.008)S(0.002)IVAK;DSSVPGS(0.565)PS(0.418)S(0.017)IVAK 204.23 2.6175e-05 19278200.0 9278.6 12329.5 9925.2 10992.1 9799.8 9799.5 12870.8 11650.1 5727.299999999999 9290.3 True False 9494.773326987275 10885.956408170956 8577.412355221111 9072.536082271987 8913.409820295214 9700.925927234095 11899.945193659476 11341.101503141937 9718.809794558407 10482.800500185245 0.9057477843653983 1.0384587981025286 0.8182367254885311 0.865468734439014 0.850288987197429 0.9254135788487692 1.1351876050153953 1.0818770712026358 0.9271195988501987 1.0 13.355736566653684 -7.08864834550574 7.113516196146205 1.0422941826583212 0.8966377305135265 0.448869522729867 0.07398462994071629 0.25041281073109406 17.398634994906985 0.029384515801516412 0.022776431117851624 8.153642289557944e-08 7.08864834550574 -0.14565645214479472 DSTLIMQLLR ddPTM_A459_Selumetinib_30min_R1 3 DSTLIMQLLR 10 0 P31947;P31947-2;E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P27348;P31946-2;P31946;P63104-2;P61981;P62258;P62258-2;K7EM20;Q04917 P31947;E7EX29;P27348;P31946-2;P63104-2;P61981;P62258;Q04917 SFN;YWHAZ;YWHAQ;YWHAB;YWHAG;YWHAE;YWHAH 14-3-3 protein sigma;14-3-3 protein zeta/delta;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein epsilon;14-3-3 protein eta 0 ;; 185.72 0.0060348 103955000.0 9781.8 11706.7 8555.8 8434.2 9198.4 8820.3 10403.5 10383.1 6352.1 10171.300000000001 False True 10009.696907930516 10336.074121702824 7393.969353645339 6961.325299542253 8366.406344109417 8731.575790191633 9618.755619094092 10107.706458937955 10779.049760971915 11476.885431851964 0.8721614385162774 0.9005992246831157 0.6442487726787575 0.606551781045264 0.7289788151836045 0.7607966326786504 0.8380980777588859 0.8807011727141488 0.9391964244111616 1.0 13.48644355974541 -7.856875244106202 1.1968674310863046 0.9841022622871592 0.7453287594809604 0.5155442993815443 0.08467362405617723 0.44487693639029 1.1490898551280748 0.0845966362973892 0.03138126380673308 1.390351967835567e-08 7.856875244106202 -0.2387735028061988 DSVSS(ph)VSDISQYR ddPTM_A459_Selumetinib_30min_R2 1 DSVSSVSDISQYR 13 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;F5H1B5;F5H2B8;F5GYM8;F5H3Q6;F5H0R8 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 DSVS(0.022)S(0.948)VS(0.03)DISQYR 122.64 0.0026083 2936300.0 14283.0 15099.0 13718.0 11759.0 17391.0 14897.0 9883.0 12768.0 9404.6 15428.0 True False 13489.208039379193 16257.04474906292 12835.398815029082 10157.40391459356 15206.18710248738 16948.92652849818 10342.579082792981 12805.152766143807 11285.782786479329 14982.553553242002 0.9003277039153535 1.085065018542526 0.8566896670462221 0.6779487807934883 1.0149262639676657 1.1312441813251977 0.6903081671652027 0.854670915784777 0.7532616350326512 1.0 13.870995910197895 -7.2838301144118 24.997707298023045 0.8124494494014106 0.9378743350220728 0.14641653659192444 0.13997698948130696 1667.0579758999038 1861146.9807871205 0.06061151108869691 0.04089830967586527 5.201994462891046e-08 7.2838301144118 0.12542488562066223 DSYDSYATHNE ddPTM_A459_Selumetinib_30min_R1 1 DSYDSYATHNE 11 0 Q14011 Q14011 CIRBP Cold-inducible RNA-binding protein 0 136.57 0.019458 3577100.0 2142.3 1963.2 2527.4 2327.0 2628.2 2174.6 2383.6 2040.0 1052.2 1605.9 False True 2192.2114218098436 1733.34763133308 2184.19296201445 1920.6331331999268 2390.479774046396 2152.7254983788216 2203.8031329526316 1985.892573146116 1785.5065503525827 1812.032907790653 1.2098077316281903 0.9565762431138675 1.2053826134303258 1.0599328107907742 1.3192253649306085 1.1880167789025216 1.2162048070306017 1.0959473001886284 0.9853609957501197 1.0 10.823393440639657 -8.091330390345044 3.5746248556723588 0.9943928262636491 1.1613383168498759 0.35195363158149384 0.09256487166177095 0.28898118116172417 6.639446594677662 0.07149006565398869 0.024592267991885765 8.103443523114344e-09 8.091330390345044 0.16694549058622676 DSYDSYATHNE ddPTM_A459_Selumetinib_30min_R2 1 DSYDSYATHNE 11 0 Q14011 Q14011 CIRBP Cold-inducible RNA-binding protein 0 145.72 0.0096509 3385200.0 29778.0 30119.0 26573.0 33332.0 35742.0 20900.0 25187.0 20861.0 28248.0 29980.0 False True 28123.05797077879 32429.03045215085 24863.322110494813 28792.12409909281 31251.770422465866 23778.785288689796 26358.24540709369 20921.70205627553 33898.389315065826 29114.399502605327 0.9659501295316832 1.1138485081668579 0.8539871175522579 0.9889307212575799 1.0734128457524694 0.8167362437463953 0.9053336444303102 0.7186032483480669 1.164316966662232 1.0 14.829445242404354 -6.758033804549534 24.999976663783137 0.9024317050254753 0.9969530065472036 0.07797265189817282 0.12657961013082017 198.50215163659036 1457186.5377748383 0.04102899460341741 0.03944930688048685 1.745686267163036e-07 6.758033804549534 0.09452130152172833 DSYESYGNSR ddPTM_A459_Selumetinib_30min_R1 4 DSYESYGNSR 10 0 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 ;;; 172.88 0.0018124000000000005 58730000.0 5538.200000000001 6468.699999999999 6959.1 7322.2 6273.1 5969.4 5939.0 5697.000000000001 3223.69 5105.13 False True 5667.229284538713 5711.341596782952 6014.092443600045 6043.515224717018 5705.699212605757 5909.353255781544 5491.016448483668 5545.8970535359895 5470.366480998022 5760.423163677245 0.9838216956479565 0.991479520601233 1.044036570355166 1.0491443168315882 0.9905000119754129 1.0258540193788868 0.9532314367297979 0.9627586196281612 0.9496466362908552 1.0 12.491959081349538 -7.261973745299191 24.999912428760876 0.9633057232118739 1.0149849473120474 0.47956993927174263 0.024263126874436058 42.044448061970776 1966978.0435798187 0.010096501570545514 0.007288670461820576 5.470490330230223e-08 7.261973745299191 0.05167922410017345 DSYESYGNSR ddPTM_A459_Selumetinib_30min_R2 4 DSYESYGNSR 10 0 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 ;;; 192.64 0.0018124000000000005 53142000.0 96847.0 76947.0 97096.0 84252.0 93205.0 70896.0 74988.0 74743.0 71094.0 81446.0 False True 91464.63144925839 82848.58747639881 90848.94907013161 72776.73225719327 81495.75463672799 80661.28047018911 78475.09058590313 74960.48975563033 85314.78653233119 79094.44235787849 1.1563977028298464 1.047464082261734 1.1486135607236159 0.9201244750914421 1.030360063327639 1.0198097118533456 0.9921694653440633 0.9477339686707282 1.0786445164668779 1.0 16.2712887055444 -5.748517048263957 24.99998946555369 0.9981916524677175 1.11048902362913 0.5505878917044942 0.04918136678198841 173.93118985427347 336490.4734535733 0.012650131431787125 0.021734100647162045 1.7843619418975217e-06 5.748517048263957 0.11229737116141258 DSYLILETLPTEYDSR ddPTM_A459_Selumetinib_30min_R2 2 DSYLILETLPTEYDSR 16 0 E9PN50;R4GNH3;E9PMD8;E9PLG2;E9PKD5;E9PM69;P17980 E9PN50;E9PM69 PSMC3 26S protease regulatory subunit 6A 0 ; 171.62 2.6982e-06 0.0 12098.8 10933.3 13804.4 14989.7 15696.0 12325.3 10424.5 9838.1 9926.3 13470.5 False True 11426.397131333817 11771.84895389957 12916.239933094292 12948.077001325206 13724.12815597964 14022.998197066438 10909.259905754872 9866.727242214874 11911.837363995252 13081.571664437794 0.8734728077358195 0.8998803244644754 0.9873614779948073 0.9897952121857427 1.0491192119742487 1.0719658582911646 0.8339410726473836 0.7542463165215489 0.9105815164685096 1.0 13.675248261079357 -10.643577556498743 5.7683409412995195 1.0000005736279507 0.9322764961454719 0.048330296331564826 0.0926556821161023 7.74787333322014e-07 1.1821516593161553e-07 0.10169224049448837 0.024663782358650004 2.2720738510961636e-11 10.643577556498743 -0.06772407748247877 DSYS(ph)SSRSDLYSSGR ddPTM_A459_Selumetinib_30min_R1 2 DSYSSSRSDLYSSGR 15 1 P38159;P38159-2;H3BUY5 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 DSYS(0.709)SS(0.008)RS(0.276)DLYS(0.006)SGR;DSYS(0.48)S(0.002)S(0.042)RS(0.474)DLYS(0.001)SGR 223.14 5.1306000000000005e-09 35349000.0 3208.1000000000004 3828.3 4976.0 5207.0 4166.3 3314.2 3769.2 3567.6 1758.58 2511.1 True False 3282.8424881240544 3380.0808562716143 4300.286531211486 4297.695197495494 3789.458900620009 3280.862157052835 3484.8862093996686 3472.9756588020005 2984.181818398636 2833.4241451853204 1.1586131549356653 1.1929314790428385 1.517699543331246 1.516784984273649 1.3374132168172652 1.157914236958777 1.2299204181348358 1.2257168291247302 1.053206885199129 1.0 11.46833086461797 -6.748478855027887 5.30111984142583 1.1523630639318596 1.3569268281135431 0.40298759089139613 0.12733318917241057 0.2130398341487471 17.31780608327619 0.04779007316378055 0.0454603627370719 1.7845188712542067e-07 6.748478855027887 0.20456376418168354 DSYVGDEAQS(ph)K ddPTM_A459_Selumetinib_30min_R1 4 DSYVGDEAQSK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 DSYVGDEAQS(1)K;DSYVGDEAQS(1)K;DSYVGDEAQS(1)K;DSYVGDEAQS(1)K 190.57 1.9161e-05 66623000.0 8615.599999999999 13276.3 13540.2 13492.8 11707.8 10148.3 16221.0 22177.0 5444.34 11815.5 True False 8816.326716960697 11721.904624015582 11701.515210994723 11136.535771224737 10648.831557179974 10046.217315919163 14997.436910397972 21588.793918951655 9238.647341139127 13332.134517716198 0.6612839605875007 0.8792218986718978 0.8776925551902696 0.8353152870177034 0.7987341819143394 0.75353404982296 1.1249089101575491 1.6193051375429586 0.692960855507608 1.0 13.702620158595623 -7.2989244329258085 6.981610675464781 1.1628087239723237 0.8094684386667887 0.305555409952314 0.2218533524444625 0.24923681618416582 37.45750037565083 0.08841315418575738 0.06007731943845458 5.024300045462175e-08 7.2989244329258085 -0.35334028530553496 DSYVGDEAQS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 DSYVGDEAQSK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 DSYVGDEAQS(1)K;DSYVGDEAQS(1)K 123.1 0.003961 32990000.0 115195.0 119173.0 137483.0 111870.0 150016.0 97843.0 109335.0 122660.0 99265.0 141514.0 True False 108792.92306212179 128313.18589840872 128637.49346017219 96633.11301348575 131169.64891994407 111319.98511967841 114419.29414319253 123016.92029254387 119120.77369583746 137428.12312247136 0.7916350786888734 0.9336748766048437 0.9360347106358627 0.7031538437541605 0.9544600183693847 0.8100233241232129 0.8325755423526077 0.8951364356691046 0.866786004125815 1.0 17.068317740147606 -9.27965324629263 0.9803694004105257 1.0007870732090314 0.8567267276702143 0.2553493899291467 0.07322831019308874 5.43910904540508 5.885909948664952 0.07884401859498613 0.02189584992595981 5.252266495513494e-10 9.27965324629263 -0.14406034553881708 DSYVGDEAQS(ph)KR ddPTM_A459_Selumetinib_30min_R1 1 DSYVGDEAQSKR 12 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 DSYVGDEAQS(1)KR 99.069 0.026406 40595000.0 1173.2 1850.6 1922.2 2184.1 1804.1 1465.6 2024.6 1927.7 830.06 1509.0 True False 1200.5332773501893 1633.9308916794005 1661.1757978888088 1802.6879356347042 1640.9194735397252 1450.8573946583294 1871.8827919851876 1876.5711339479237 1408.551194816257 1702.6948489047218 0.705078351603898 0.9596146324929834 0.9756156829612654 1.058726369433903 0.9637190566443927 0.8520947811591785 1.0993648058483867 1.1021182892254886 0.827248168233036 1.0 10.733604188017551 -4.751551619903396 3.716736859295785 0.9888592520886531 0.664642046328987 0.4785513957137899 0.08700145854619845 0.26342478118603396 6.092822044947635 0.021940369357685726 0.246999340704169 1.7719374215181653e-05 4.751551619903396 -0.32421720575966606 DSYVGDEAQS(ph)KR ddPTM_A459_Selumetinib_30min_R2 3 DSYVGDEAQSKR 12 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 DSYVGDEAQS(1)KR;DSYVGDEAQS(1)KR;DSYVGDEAQS(1)KR 162.88 0.00088993 77451000.0 229706.0 223274.0 246846.0 202141.0 223990.0 158273.0 178691.0 202228.0 158531.0 247959.0 True False 216939.8601059748 240398.39786093647 230964.1971056037 174609.04708732493 195850.3737039935 180073.66909075592 187000.48556949937 202816.4499993524 190241.62972623517 240799.77939514723 0.9009138656642255 0.9983331316365033 0.9591545211783457 0.7251212917466808 0.8133328618321003 0.747814925508129 0.776580801025717 0.8422617766045998 0.7900407143399113 1.0 17.877474544833127 -5.74276663013375 24.950398046361556 0.8027269846057935 0.9573538688472273 0.41835867475417887 0.07439267198451668 194.921852750183 260451.15777521083 0.018807249961568785 0.032502160286452676 1.8081454791682504e-06 5.74276663013375 0.15462688424143378 DSYVGDEAQSK ddPTM_A459_Selumetinib_30min_R1 1 DSYVGDEAQSK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 144.55 0.010357 146760000.0 1858.7 1983.5 2266.2 2255.8 2104.3 1834.7 1794.9 1872.3 1165.1 1523.6 False True 1902.004093599384 1751.2708978958674 1958.4624873455523 1861.8668766103965 1913.966436544341 1816.2445837743148 1659.509247917719 1822.640521912487 1977.0896044628353 1719.1689011207654 1.1063509189582386 1.018672974339039 1.139191434924623 1.08300404654633 1.1133091316953108 1.0564666348898375 0.9652973869151815 1.0601870012447678 1.1500263895966973 1.0 10.747495575166846 -6.9463856843042855 8.411278878857605 1.0435349481942 1.0897617138631184 0.15965151236337083 0.05292239013015239 0.5581521873914159 79.16856163928519 0.01901846357682141 0.01675042850927824 1.1313951578051681e-07 6.9463856843042855 0.04622676566891837 DSYVGDEAQSK ddPTM_A459_Selumetinib_30min_R2 6 DSYVGDEAQSK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 ;;;;; 183.03 0.00045887 555177900.0 429753.0 383738.0 417242.0 424686.0 437111.0 335926.0 382918.0 389071.0 324353.0 358478.0 False True 405869.0486975654 413169.4706878537 390397.10397874186 366843.0341757863 382197.20835807966 382196.7572673878 400724.4457376224 390203.13219582883 389232.6631800323 348127.80870229943 1.1658621878283881 1.1868327101704605 1.121418899093433 1.0537596394360187 1.0978646313340472 1.0978633355723166 1.1510842734206874 1.12086171354817 1.1180740333010384 1.0 18.40925753662961 -14.522878745280336 0.22038771500453128 0.3915497441754031 1.137438622528055 0.5305681759866547 0.03531307777151607 143.45204758143967 1.4315914936882668 38.894100785076965 0.07677177725768494 3.0000000000000132e-15 14.522878745280336 0.7458888783526519 DSYVGDEAQSKR ddPTM_A459_Selumetinib_30min_R1 4 DSYVGDEAQSKR 12 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 ;;; 110.98 0.0094601 881030000.0 9103.800000000001 8370.6 18384.7 19459.199999999997 13856.7 10884.199999999999 10657.8 11101.9 7647.8 8937.599999999999 False True 9315.900827088859 7390.566260613632 15888.158719928415 16061.01601442372 12603.36393159908 10774.714830062894 9853.873565355987 10807.4415479465 12977.758026788146 10084.828019596316 0.9237540599588493 0.732840088720667 1.5754516278369217 1.5925919592495563 1.2497351374866161 1.0684083862536897 0.9770988207442357 1.0716535301292238 1.2868596273104944 1.0 13.299898860883456 -6.763863949519826 24.39516711183791 1.0788008177326291 1.2291112461782054 0.06308668076392177 0.25534755526798997 157.23174325424068 1581990.7600654694 0.09852063205319836 0.09100209764087282 1.72240806547746e-07 6.763863949519826 0.1503104284455763 DSYVGDEAQSKR ddPTM_A459_Selumetinib_30min_R2 3 DSYVGDEAQSKR 12 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 ;; 101.89 0.016395 53424500.0 173434.0 226708.0 226323.0 254413.0 223072.0 124333.0 105030.0 118968.0 110289.0 188190.0 False True 163795.23259131084 244095.77461888542 211761.62458185104 219761.51051309588 195047.70107101757 141458.7421674004 109914.10311299686 119314.17718378741 132349.881732133 182756.4657236587 0.8962486330797256 1.335634138318128 1.1587093443908587 1.2024828212939482 1.0672547222813125 0.7740286594363041 0.6014238822017663 0.652858856245334 0.7241871372816753 1.0 17.479562922488384 -6.7315556529705205 3.1812115416347653 0.711614260565088 1.1601845588884245 0.6434437803114585 0.1420795068150034 0.1369445474971147 2.856444745412966 0.04886947510332341 0.04631605294420821 1.8554290289463532e-07 6.7315556529705205 0.4485702983233365 DT(ph)CYSPKPSVYLSTPSS(ph)ASK ddPTM_A459_Selumetinib_30min_R2 1 DTCYSPKPSVYLSTPSSASK 20 1 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 2 DT(0.675)CY(0.056)S(0.266)PKPS(0.002)VYLS(0.036)T(0.031)PS(0.325)S(0.583)AS(0.025)K 81.15100000000002 0.012857 4064400.0 28571.0 27692.0 29305.0 27788.0 28802.0 25023.0 29037.0 25702.0 16470.0 34933.0 True False 26983.13819877497 29815.887356185864 27419.548204871517 24003.226463026265 25183.635266853053 28469.69111382224 30387.27803572393 25776.78856480484 19764.460210249712 33924.39352316585 0.7953904372777977 0.8788922736621829 0.8082546320584217 0.7075506433633149 0.7423459243171431 0.8392100243260422 0.8957353361372095 0.7598304903285219 0.5826031995753502 1.0 15.050035403920418 -11.659581152333862 2.490847718874112 1.4728021134684486 0.784154653728368 0.3716094186094213 0.08602000534600138 7207641.324479099 2184987.043514649 19271391.09336693 0.023078086648920207 2.1898725899046364e-12 11.659581152333862 -0.6886474597400806 DT(ph)HEDHDTSTENTDESNHDPQFEPIVSLPEQEIK ddPTM_A459_Selumetinib_30min_R2 1 DTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIK 34 0 C9JJ34;P43487-2;P43487 C9JJ34 RANBP1 Ran-specific GTPase-activating protein 1 DT(0.26)HEDHDT(0.242)S(0.242)T(0.242)ENT(0.012)DES(0.003)NHDPQFEPIVSLPEQEIK 46.464 0.005508699999999999 4938900.0 3826.1 6590.5 7816.8 9319.2 9561.3 4915.1 6751.4 6179.6 6961.6 8893.4 True False 3613.4606790918365 7095.970158202473 7313.875598288333 8049.908883483315 8360.124014893483 5592.110410164558 7065.353477645306 6197.581612912149 8354.114523356067 8636.624434171797 0.4183880758777427 0.8216138390974199 0.8468442334194993 0.9320665666128685 0.9679851287518872 0.6474879685677578 0.81806885681985 0.7175930434569673 0.9672893139016272 1.0 13.076251839684794 -4.760439657969242 4.938231296525877 0.8483229313591135 0.3894758511719361 0.5977102447048522 0.10809055012420427 0.12810988147303945 8.029652676127524 0.026997013862615448 0.20547805100342093 1.7360424564726742e-05 4.760439657969242 -0.4588470801871774 DT(ph)LSNPQSPQPSPYNSPKPQHK ddPTM_A459_Selumetinib_30min_R2 1 DTLSNPQSPQPSPYNSPKPQHK 22 1 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5;Q96PU5-2;Q96PU5-3;Q96PU5-9;Q96PU5-6;Q96PU5-5 A0A1B0GVY1;Q96PU5-9 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 DT(0.686)LS(0.302)NPQS(0.012)PQPSPYNSPKPQHK 84.947 0.00036786 3874800.0 32237.0 14985.0 20026.0 27779.0 20751.0 19341.0 29772.0 25067.0 22762.0 20122.0 True False 30445.396594935726 16134.30131563069 18737.548962660207 23995.452278552122 18144.073863706257 22005.047189882756 31156.456992098832 25139.940819934753 27315.03602341858 19541.025576765325 1.5580244995501116 0.8256629751723318 0.9588825770198843 1.2279525547053785 0.9285118527903636 1.1260947949450106 1.5944125793041533 1.286521053932126 1.3978302170535364 1.0 14.254218566184598 -7.027393069483491 24.164470821171324 1.3459515016227857 1.0782103945535715 0.16512575248563266 0.23253214792491078 704.1989561211819 621198.4194378685 0.08437760954648017 0.06556497082797148 9.388731743893108e-08 7.027393069483491 -0.26774110706921417 DT(ph)PGHGSGWAETPR ddPTM_A459_Selumetinib_30min_R2 1 DTPGHGSGWAETPR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 DT(1)PGHGSGWAETPR 96.247 0.016175 6171300.0 20736.0 18533.0 33438.0 38994.0 49935.0 27838.0 20908.0 25966.0 34973.0 37825.0 True False 19583.576132784907 19954.42150701259 31286.635484541675 33682.94993159804 43661.71887543601 31672.431811796516 21880.263428416045 26041.55676109731 41968.57722726556 36732.89396884745 0.5331345836620826 0.5432303135150637 0.8517334765694025 0.9169696773732009 1.1886272536126552 0.8622362245309987 0.5956585791190949 0.7089437816465731 1.1425339169535187 1.0 15.164784941560594 -5.2889677320933846 3.8847413084931026 0.8989635332512685 0.5294313598481604 0.43763204541597633 0.16835768344491805 0.21895320242491012 7.391647481865637 0.04845094693779783 0.12122734131535824 5.140818462394155e-06 5.2889677320933846 -0.3695321734031082 DT(ph)PTSAGPNSFNK ddPTM_A459_Selumetinib_30min_R2 2 DTPTSAGPNSFNK 13 0 Q8WW12;Q8WW12-3 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 DT(0.979)PT(0.016)S(0.005)AGPNSFNK;DT(0.978)PT(0.017)S(0.005)AGPNSFNK 139.64 0.0021616 12420400.0 107103.0 73750.0 78802.0 99087.0 89340.0 78779.0 118435.0 113268.0 79668.0 70490.0 True False 101150.6440272793 79406.38785637375 73731.96511313034 85591.17966539096 78116.31049026645 89630.09216544002 123942.46217450046 113597.5911274732 95603.82610990755 68454.77054498484 1.4776273913708973 1.1599832593725823 1.077090238213239 1.2503318466190019 1.1411375696443617 1.3093330304356199 1.8105745032488576 1.659454705977327 1.396598445203783 1.0 16.06286346452088 -7.014954318691384 23.625929549438222 1.527088987033572 1.2128192913781128 0.19557840375026336 0.22149901045813938 405.438838794219 640541.2563355565 0.07979212493373758 0.06413608097037192 9.661524984926997e-08 7.014954318691384 -0.31426969565545915 DT(ph)QSPSTCSEGLLGWSQK ddPTM_A459_Selumetinib_30min_R2 1 DTQSPSTCSEGLLGWSQK 18 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DT(0.991)QS(0.009)PSTCSEGLLGWSQK 292.65 1.4195999999999993e-80 15145000.0 56176.0 51974.0 62848.0 67318.0 68454.0 52270.0 67148.0 54861.0 52226.0 60185.0 True False 53053.962810345554 55960.23867724989 58804.42810372852 58149.17226997275 59854.196533475435 59469.7180401826 70270.51505123771 55020.63642727252 62672.659316363184 58447.302670590485 0.9077230323075499 0.9574477541357603 1.0061102123933896 0.9948991589518168 1.024071151252509 1.017492943606901 1.2022884177783697 0.9413716957541961 1.0722934413173324 1.0 15.834848825802437 -4.854846917054705 0.6850070276310971 1.0486148220364633 0.8320380541362785 0.32278826619658707 0.06338614692769166 3.4610305131038586 1.3142032284832703 0.0281367959802606 0.5764874107923547 1.3968606488204671e-05 4.854846917054705 -0.21657676790018476 DT(ph)SPSSGSAVSSSK ddPTM_A459_Selumetinib_30min_R1 4 DTSPSSGSAVSSSK 14 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-7 F8WF16 PPHLN1 Periphilin-1 1 DT(0.624)S(0.376)PSSGSAVSSSK;DT(0.635)S(0.363)PS(0.002)SGSAVSSSK;DT(0.457)S(0.457)PS(0.021)S(0.051)GS(0.014)AVSSSK;DT(0.944)S(0.056)PSSGSAVSSSK 188.09 0.00016404 597610700.0 14894.7 16341.7 15914.6 16466.0 14778.0 12691.2 15620.2 14647.1 8941.1 12678.1 True False 15241.71752995896 14428.406166949777 13753.48473264033 13590.522205100977 13441.332509267811 12563.538050687623 14441.955738104823 14258.611327513961 15172.393667893439 14305.457630151726 1.0654477419746342 1.0085945196565338 0.961415222652647 0.9500235893506913 0.9395947236904473 0.8782339143214373 1.0095416806286155 0.9967252845837643 1.0606017689300946 1.0 13.804278029618105 -9.915953374010266 6.696812095567103 0.9999998199423376 0.9810195374186064 1.594942728155857e-05 0.05376615436332321 76336208.76896583 0.0 0.055644437636325 0.013911109409081255 1.2135191272599406e-10 9.915953374010266 -0.018980282523731185 DT(ph)SPSSGSAVSSSK ddPTM_A459_Selumetinib_30min_R2 2 DTSPSSGSAVSSSK 14 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-7 F8WF16 PPHLN1 Periphilin-1 1 DT(0.993)S(0.007)PSSGSAVSSSK;DT(0.611)S(0.388)PS(0.001)SGSAVSSSK 194.59 0.00028284 37608000.0 45165.0 41102.0 46823.0 53696.0 51171.0 38576.0 45641.0 41215.0 35440.0 43754.0 True False 42654.910109820165 44254.39123623975 43810.4591570278 46382.512169233436 44742.44150545579 43889.493841937714 47763.396935925746 41334.92882648943 42528.99027633579 42490.708333455426 1.0038644160760073 1.0415074959198944 1.0310597510687591 1.091591879458356 1.0529935428312793 1.0329197973708746 1.124090390800071 0.9727992412389137 1.0009009485692717 1.0 15.374859773580635 -7.804835086855576 24.99983345197496 0.9901374822956378 1.0532369118229954 0.4408462623213397 0.03238051598600279 132.8151834729007 76511.8191709216 0.017518090324098567 0.008415494619379443 1.5673461200545415e-08 7.804835086855576 0.06309942952735759 DTAAVVS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 DTAAVVSR 8 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 DTAAVVS(1)R 86.882 0.03325 25625000.0 55477.0 38765.0 48301.0 49275.0 50464.0 56490.0 58438.0 52431.0 47714.0 51721.0 True False 52393.81043202685 41738.150850879094 45193.36624615249 42563.65999588382 44124.26116611599 64270.9847348367 61155.48279270021 52583.5655295807 57258.13324054979 50227.68034270353 1.0431262219267108 0.8309790650513749 0.8997701255124284 0.8474144078617988 0.8784849482408127 1.279592931553193 1.217565341967542 1.046904120811532 1.1399716819466372 1.0 15.616195028332758 -6.743388204321308 24.999889256564803 1.1447857276104634 0.8931936964375766 0.6280274307076854 0.09096293570525563 151.60773967821598 209968.04503136143 0.029958993469824415 0.029901078172515194 1.8055594627398698e-07 6.743388204321308 -0.25159203117288675 DTASLSTTPSES(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 DTASLSTTPSESPR 14 0 H0YJ30;G3V582;F5H039;Q9NQX3;Q9NQX3-2 H0YJ30 GPHN Gephyrin;Molybdopterin adenylyltransferase;Molybdopterin molybdenumtransferase 1 DTASLS(0.016)T(0.027)T(0.214)PS(0.027)ES(0.715)PR 139.64 0.00056902 16754000.0 2007.8 2347.1 2783.5 2723.5 2958.6 2149.4 2494.1 2065.0 1358.9 1915.6 True False 2054.5778335012865 2072.300440862812 2405.515988671055 2247.89185142673 2690.995152383256 2127.7789874990544 2305.96802898857 2010.2294919346707 2305.954049870866 2161.4859195241124 0.9505395408514327 0.9587388111781288 1.1128992175904018 1.0399752462517273 1.2449746390093182 0.9844056666200818 1.0668438818682047 0.9300220157701775 1.0668374145035193 1.0 11.077807722839507 -10.612210456107636 14.64821070501878 0.9999937074875243 1.0412814346828534 0.017166136012854216 0.08865053219048331 0.0 0.0 0.08738591634325454 0.02119419783968395 2.442246769966793e-11 10.612210456107636 0.04128772719532914 DTCIQS(ph)PSKECQK ddPTM_A459_Selumetinib_30min_R2 1 DTCIQSPSKECQK 13 1 Q03188;Q03188-2 Q03188 CENPC Centromere protein C 1 DT(0.003)CIQS(0.498)PS(0.498)KECQK 65.467 0.041701 26836000.0 113750.0 96773.0 90189.0 101660.0 100080.0 70308.0 93305.0 95438.0 72329.0 99311.0 True False 107428.2303773286 104195.17792576074 84386.33793035841 87813.73262671851 87507.05567344817 79992.2888075216 97643.86738034994 95715.70877938849 86796.82104111422 96443.63338903415 1.1138965487123946 1.0803738335475026 0.8749809081742177 0.9105187096435453 0.9073388527417083 0.8294201078556306 1.0124449271469718 0.9924523311278687 0.8999746068358226 1.0 16.557398383181713 -5.17922772652866 5.67776964930678 0.9263855678307438 1.1031081340647682 0.5965122314881024 0.055607211272429506 0.15288010238209282 8.10317629780965 0.014751942573593175 0.040621244392202376 6.6186935507114115e-06 5.17922772652866 0.17672256623402438 DTCYS(ph)PKPSVYLSTPSS(ph)ASK ddPTM_A459_Selumetinib_30min_R2 1 DTCYSPKPSVYLSTPSSASK 20 1 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 2 DT(0.186)CY(0.097)S(0.716)PKPS(0.002)VYLS(0.066)T(0.057)PS(0.079)S(0.729)AS(0.069)K 89.882 0.0034936 4539800.0 31825.0 31348.0 25694.0 31277.0 25940.0 24738.0 28878.0 29411.0 20097.0 32868.0 True False 30056.29390556905 33752.29080029302 24040.87601351199 27017.018644165564 22681.185293457675 28145.434950794675 30220.884220671436 29496.58114074686 24116.96155709705 31919.01543868019 0.9416422622217272 1.0574352102161404 0.753183507796381 0.8464239348506258 0.7105853668021381 0.8817764133378436 0.9467987594645253 0.924106860295015 0.755567213638788 1.0 14.962128530995667 -5.252571150199211 24.997795356734855 0.8487506242718911 0.9995387395568125 0.294431551187436 0.09103535910364029 782.4440121709133 2205543.603629307 0.02326962443760784 0.05957005359526225 5.590219358463914e-06 5.252571150199211 0.15078811528492142 DTCYS(ph)PKPSVYLSTPSSASK ddPTM_A459_Selumetinib_30min_R1 1 DTCYSPKPSVYLSTPSSASK 20 1 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 DT(0.06)CY(0.116)S(0.802)PKPS(0.02)VY(0.001)LS(0.001)T(0.001)PSSASK 68.97 0.006977199999999999 31103000.0 3947.2 4122.2 5332.8 5532.9 4414.5 4129.9 4877.7 5433.5 2646.2 3829.2 True False 4039.1620800858054 3639.570907641209 4608.635050973595 4566.682880396164 4015.209254443277 4088.3569556491766 4509.771161941198 5289.385929504614 4490.408129198827 4320.715119566577 0.9348364722761413 0.8423538249858751 1.0666371013685112 1.05692755805994 0.9292927544008163 0.94622229017943 1.0437557295824644 1.2241922420553397 1.0392742879214105 1.0 12.077054396603975 -7.497341610889768 6.454806348391669 1.10574023252928 0.9667163998083312 0.32331919373253504 0.08130640910781957 0.19299142501332303 29.981337148628924 0.03661045115797504 0.023389391072866965 3.181693854519086e-08 7.497341610889768 -0.13902383272094876 DTCYS(ph)PKPSVYLSTPSSASK ddPTM_A459_Selumetinib_30min_R2 2 DTCYSPKPSVYLSTPSSASK 20 1 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 DT(0.07)CYS(0.921)PKPS(0.008)VYLSTPSSASK;DT(0.147)CY(0.36)S(0.422)PKPS(0.052)VY(0.013)LS(0.003)T(0.003)PSSASK 103.71 0.00031112 47494000.0 169588.0 145514.0 171145.0 167682.0 167128.0 129717.0 157213.0 151851.0 122059.0 171864.0 True False 160162.97787455295 156674.45589874437 160133.7170285871 144843.42233241544 146131.88649672296 147584.33929631472 164523.7160116494 152292.8612697136 146474.21061341054 166901.83976370087 0.9596238010396483 0.9387221622036258 0.959448483343886 0.8678359839381299 0.8755558758586247 0.8842583131813537 0.9857513628644333 0.9124696377543194 0.8776069264472356 1.0 17.34864033209322 -10.63541651812448 4.4971314920697205 1.0000072520342786 0.9178782194205749 0.28004090443342344 0.03948258852710721 3.5132061280382316e-06 6.932857182304281e-07 0.040470153664806365 0.00981445220312676 2.3151731753761942e-11 10.63541651812448 -0.08212903261370375 DTDDIES(ph)PKR ddPTM_A459_Selumetinib_30min_R1 1 DTDDIESPKR 10 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0;D6RGH8 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 DTDDIES(1)PKR 132.56 0.0043435 6043600.0 3682.3 4451.9 5073.1 5347.8 4350.6 4379.0 4412.1 3924.3 2715.2 3760.0 True False 3768.0904254914767 3930.6694783678413 4384.200884543607 4413.907120638836 3957.0889981608148 4334.951235813881 4079.2917447979116 3820.2148160771085 4607.49608963822 4242.632625501495 0.8881491182720717 0.9264694413420304 1.0333680220604484 1.0403698623604245 0.9326965937082692 1.0217597464738002 0.961500112047935 0.9004349782997167 1.0859993066436189 1.0 12.050744044055868 -5.062406014116869 4.957607025491139 0.9921373132288873 0.8956497006636631 0.3323041295952307 0.05172894747196757 0.21959471574909833 10.789162550005335 0.013043110295849213 0.03939599403617843 8.661517474061274e-06 5.062406014116869 -0.0964876125652242 DTDFEHR ddPTM_A459_Selumetinib_30min_R2 3 DTDFEHR 7 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 ;; 128.57 0.0069545 9587900.0 111868.0 101763.0 104553.0 119082.0 127609.0 93746.0 94807.0 120758.0 92266.0 122228.0 False True 105650.82440308563 109567.89488038233 97826.17380869915 102862.82617209182 111577.6165810656 106658.6605585413 99215.71335650659 121109.38578743704 110721.77812743756 118698.96005351716 0.8900737155190863 0.9230737559198668 0.824153587905006 0.8665857403107374 0.9400050053577487 0.898564406212596 0.8358600051068159 1.0203070501446103 0.9327948456963484 1.0 16.856947769718182 -7.765120344484597 24.999999866243822 0.9824132167190678 0.8841281200214914 0.5862581759112678 0.03914648705005182 70.62487506059131 479646.85922180593 0.020519773682349054 0.01046319286325737 1.717432414824516e-08 7.765120344484597 -0.09828509669757635 DTDS(ph)DTQDANDSSCK ddPTM_A459_Selumetinib_30min_R1 1 DTDSDTQDANDSSCK 15 0 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2;A0A087WWE6;A0A087X246 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 DTDS(0.677)DT(0.323)QDANDSSCK 195.45 8.3564e-21 0.0 636.07 858.57 547.44 802.12 1103.0 709.35 1199.3 769.15 238.48 409.62 True False 650.8891934232311 758.0482252616359 473.1006548726718 662.0447996572088 1003.2338447504663 702.2145830382682 1108.8358354380307 748.7496434486936 404.6831421099449 462.19871703668167 1.408245348659361 1.6400915825161726 1.023587122668549 1.4323813010598787 2.1705682161615485 1.5192915020197644 2.399045680064122 1.6199734353422497 0.875560937738016 1.0 8.85236944497753 -6.021229488585874 24.72121627199911 1.6770263401034216 1.3593192877553273 0.038568122128422755 0.45691193985231815 1676.8689115937602 1952672.437300816 0.13452075733708385 0.1755788469254243 9.522928233346522e-07 6.021229488585874 -0.31770705234809427 DTDS(ph)DTQDANDSSCK ddPTM_A459_Selumetinib_30min_R2 1 DTDSDTQDANDSSCK 15 0 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2;A0A087WWE6;A0A087X246 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 DTDS(0.999)DT(0.001)QDANDSSCK 186.17 3.8955e-14 0.0 8574.3 9293.4 11586.0 14020.0 13264.0 9777.9 9020.7 10956.0 10854.0 13121.0 True False 8097.774731642439 10006.173897009154 10840.569373883005 12110.451814151005 11597.657738335494 11124.716970061241 9440.180424177945 10987.880146136558 13025.103286098987 12742.162637547855 0.635510231817352 0.7852806608764786 0.8507636954765161 0.9504235786839385 0.910179697766547 0.8730634890249775 0.7408617118384736 0.8623245879595132 1.022205072765072 1.0 13.637322536396448 -4.828457746720496 1.608489616085074 0.8939205076681939 0.5571138611809973 0.5510158260548383 0.07549593062256692 0.7733542225211686 2.088591064275128 0.02221270644677789 0.4012542515110573 1.4843702900546112e-05 4.828457746720496 -0.3368066464871966 DTDSEEEIR ddPTM_A459_Selumetinib_30min_R1 2 DTDSEEEIR 9 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 ; 154.12 0.012857 21129000.0 9140.2 10631.9 7119.8 7914.6 9075.0 7721.9 9767.2 8918.900000000001 4679.200000000001 8647.1 False True 9353.148876266787 9387.11220536378 6152.970266261964 6532.463685442259 8254.167852321385 7644.224696924225 9030.452240382168 8682.341799329846 7940.2606447536655 9757.039514886696 0.958605206220219 0.9620861113703082 0.630618565895335 0.6695128861039688 0.845970526175248 0.7834573884077372 0.9255319942697839 0.8898541187706434 0.8137981436519653 1.0 13.252227755699009 -7.25842337216271 24.783483786172077 0.8981172423056532 0.8026790954815434 0.16328869509205268 0.10845040033834387 516.393485637809 4243392.263427296 0.04642260764267069 0.03435990048066703 5.5153950859490674e-08 7.25842337216271 -0.09543814682410978 DTDSEEEIR ddPTM_A459_Selumetinib_30min_R2 1 DTDSEEEIR 9 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 132.76 0.045517 30698000.0 36711.0 32306.0 39059.0 43623.0 41054.0 36408.0 38342.0 46607.0 33947.0 45293.0 False True 34670.74958577677 34783.766319837516 36545.98646422373 37681.47214612766 35896.42949258336 41422.871521082205 40124.978973231664 46742.61865379581 40737.34855843029 43985.273404653206 0.7882354002171316 0.7908048223285055 0.83086868934541 0.8566838223208891 0.8161010882516391 0.9417440955749539 0.9122366616683765 1.0626879188353733 0.9261588119200069 1.0 15.424732959155387 -6.923053038334021 0.9956804341048663 0.996625595131638 0.8043525387195147 0.7674181641171697 0.04220834653421425 0.23820902340739203 0.4956146252899256 0.024983869328493353 0.019363250790687726 1.1938422972395095e-07 6.923053038334021 -0.19227305641212322 DTDSEEEIREAFR ddPTM_A459_Selumetinib_30min_R1 3 DTDSEEEIREAFR 13 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 ;; 113.22 0.01308 278500700.0 7967.179999999999 6885.99 14073.2 15770.7 10626.539999999999 9085.9 9081.85 8272.23 5833.64 6201.07 False True 8152.799792566381 6079.775089590098 12162.13673855415 13016.643297703517 9665.371333268016 8994.504095337144 8396.79874266062 8052.823588410046 9899.261007792098 6997.037738036848 1.1651787653290269 0.8689070028220106 1.738183670560918 1.8603077166417545 1.381351894205993 1.285473143362054 1.200050515236538 1.1508904038967522 1.4147788504810215 1.0 12.772528557411196 -6.891123559602279 3.225538154835192 1.2076940702297985 1.4172178820283703 0.11499462738082644 0.274558082994161 0.664312938613487 13.7242864554318 0.1152704951078944 0.10009124408431956 1.2849210395498344e-07 6.891123559602279 0.20952381179857182 DTDSEEEIREAFR ddPTM_A459_Selumetinib_30min_R2 2 DTDSEEEIREAFR 13 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 ; 141.89 0.0022679 67824000.0 238889.0 274740.0 289090.0 281430.0 287630.0 201840.0 139302.0 134014.0 124343.0 316980.0 False True 225612.50572843605 295811.6745716626 270490.26413739263 243098.74850617163 251495.34795517483 229641.62787890653 145779.81902167652 134403.9585527881 149215.07443370248 307827.96378705214 0.7329175132526597 0.960964270212624 0.8787059525381884 0.7897227578529591 0.8169996801497643 0.7460063895876822 0.47357562070781667 0.436620367101429 0.48473528070024796 1.0 18.231764769730013 -7.059517900751967 3.615250479712807 0.5530209332627716 0.8402854755077117 0.3111306273719412 0.16001589658297524 0.23483021982666352 6.087235597708302 0.06069180644024744 0.04760832304000177 8.719309612919902e-08 7.059517900751967 0.28726454224494014 DTEEPLPVKESDQTLAALLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 DTEEPLPVKESDQTLAALLSPK 22 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 DTEEPLPVKESDQTLAALLS(1)PK;DTEEPLPVKESDQTLAALLS(1)PK;DTEEPLPVKESDQT(0.004)LAALLS(0.996)PK;DTEEPLPVKESDQTLAALLS(1)PK 122.6 1.7851e-05 134652500.0 7778.52 5528.150000000001 18213.329999999998 18259.77 8769.31 8742.52 6332.35 7015.13 5751.45 4958.919999999999 True False 7959.744381634841 4880.911628032791 15740.059824660375 15071.043947834125 7976.127458847429 8654.578186373043 5854.695741295765 6829.065964046329 9759.79058071219 5595.445685971245 1.4225398347787208 0.8723007785188737 2.81301270855393 2.693448349542531 1.4254677654802308 1.5467182905682695 1.0463323334501315 1.2204686359780033 1.7442382838567587 1.0 12.450037333349421 -6.492841147485877 24.41469673770709 1.328458657913685 1.9505085159657047 0.22780963789648323 0.5618547939029007 889.0970848161348 722662.6229418297 0.19033267383362498 0.21547071612619378 3.2148362188563065e-07 6.492841147485877 0.6220498580520197 DTEEPLPVKESDQTLAALLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DTEEPLPVKESDQTLAALLSPK 22 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 DTEEPLPVKESDQTLAALLS(1)PK;DTEEPLPVKESDQTLAALLS(1)PK 100.94 6.9468e-05 7390600.0 32694.0 65014.0 35703.0 46488.0 35288.0 15421.099999999999 10299.3 8929.7 5870.4 41984.0 True False 30876.99836445169 70000.36474704133 33405.907850487216 40156.25420372699 30854.80596127737 17545.216546192074 10778.237857675784 8955.683948608585 7044.644032680624 40771.81283246774 0.7573123739021844 1.7168813423792153 0.8193383008931394 0.9849023483142608 0.7567680664104987 0.43032711393740936 0.2643551294116795 0.21965380802192153 0.17278221259445145 1.0 15.315284484187217 -6.386496220684899 1.2600845030201109 0.3403445876400176 1.171834088787551 0.4662049367514991 0.3263861472718416 0.34224179965990315 1.1182049873041382 0.13047026913114185 0.16664461115258572 4.1068021367841516e-07 6.386496220684899 0.8314895011475333 DTFEHDPSES(ph)IDEFNK ddPTM_A459_Selumetinib_30min_R1 2 DTFEHDPSESIDEFNK 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 DTFEHDPS(0.001)ES(0.999)IDEFNK;DTFEHDPSES(1)IDEFNK 172.95 3.573e-06 13273200.0 4906.1 6303.6 4269.2 4200.6 4509.5 4357.4 6226.1 5659.4 3123.0 5061.9 True False 5020.402584391206 5565.571581535865 3689.4660890369905 3467.0440650277674 4101.616521216888 4313.568512202647 5756.460264338132 5509.294327678004 5299.502905104654 5711.644172081391 0.8789767767626377 0.9744254743214693 0.64595517120467 0.6070133153558015 0.7181148540845131 0.7552236067658836 1.0078464433193866 0.9645724001168567 0.9278419217724924 1.0 12.479690388825352 -7.2558976102680015 24.065908862214705 0.9721128960900911 0.7583925504250566 0.5118878631777877 0.10122860950295287 258.2145837768994 1121336.9166735746 0.04475116967402306 0.033627097433063316 5.5475648752493655e-08 7.2558976102680015 -0.2137203456650345 DTFEHDPSES(ph)IDEFNK ddPTM_A459_Selumetinib_30min_R2 3 DTFEHDPSESIDEFNK 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 DTFEHDPS(0.026)ES(0.974)IDEFNK;DTFEHDPS(0.001)ES(0.999)IDEFNK;DTFEHDPS(0.096)ES(0.904)IDEFNK 123.54 0.00089845 17741300.0 168975.0 136309.0 163324.0 189772.0 176320.0 187889.0 233552.0 234410.0 203300.0 150118.0 True False 159584.0459605193 146763.46199748415 152815.91165372604 163924.72622504068 154169.1052792004 213769.0042634753 244412.63077450814 235092.0942913355 243965.68067661065 145783.70328659491 1.0946631369817408 1.0067206326139426 1.0482372734989902 1.1244379346214197 1.0575194744238365 1.4663436271969899 1.6765428869235095 1.6126088787110175 1.673477042883186 1.0 17.153469928658005 -6.806798518437472 4.45834690744529 1.5445946892129583 1.0630974482753126 0.5534617558410404 0.1856816091894767 0.13486482255693383 5.7416812860689825 0.06239483736371223 0.05635558749262003 1.5602761914473024e-07 6.806798518437472 -0.4814972409376457 DTGKTPVEPEVAIHR ddPTM_A459_Selumetinib_30min_R1 2 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RIP1;E5RJX2 P60866 RPS20 40S ribosomal protein S20 0 ; 96.707 0.0079641 13164100.0 13618.5 13054.8 25008.9 26558.0 19452.7 15937.900000000001 14400.0 13630.3 9079.3 9951.2 False True 13935.784553011887 11526.33794698814 21612.828744054434 21920.143855403374 17693.206719653135 15777.579196455374 13313.796406493491 13268.780166545828 15406.908974164804 11228.533452896405 1.2411046029717394 1.0265221184352367 1.9248131409787443 1.9521822638154998 1.5757362075711825 1.4051326704989724 1.185711069245574 1.1817019757930312 1.372121215900246 1.0 13.454881890689789 -7.055990593877395 3.062897076142599 1.2004474724114742 1.5572468930663328 0.27621629227427 0.27283989889590726 0.414139908380245 7.6917274567208 0.12411755874691018 0.09691292161094016 8.790415552563057e-08 7.055990593877395 0.3567994206548586 DTGKTPVEPEVAIHR ddPTM_A459_Selumetinib_30min_R2 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RIP1;E5RJX2 P60866 RPS20 40S ribosomal protein S20 0 69.71600000000001 0.04284 4992000.0 35528.0 44810.0 37141.0 48900.0 40883.0 28755.0 21272.0 17376.0 14208.0 43952.0 False True 33553.49598985255 48246.78291314056 34751.38849606322 42239.73564279488 35746.91204134274 32715.7402380993 22261.19014966835 17426.56128324835 17049.997004689 42682.99155898965 0.7861092853222399 1.1303514854731194 0.8141741529066765 0.9896151628551582 0.8374978120251725 0.7664818946180191 0.5215470925673631 0.40827881661396964 0.39945646689560654 1.0 15.381373674644989 -6.985100431785334 2.0595128495885673 0.5322207078401093 0.9297395952440767 0.4061285815241271 0.18356876576595957 0.2712345785998586 2.316814361942587 0.07615737792927899 0.05994505930351678 1.0349028149019693e-07 6.985100431785334 0.39751888740396735 DTGS(ph)PPASEGPTDGSR ddPTM_A459_Selumetinib_30min_R1 2 DTGSPPASEGPTDGSR 16 0 Q969R8 Q969R8 ITFG2 Integrin-alpha FG-GAP repeat-containing protein 2 1 DT(0.015)GS(0.985)PPASEGPTDGSR;DT(0.002)GS(0.998)PPASEGPTDGSR 209.53 5.3646e-08 11034100.0 1777.0700000000002 2188.2799999999997 1944.71 2171.13 1825.05 1518.6 1815.2599999999998 1849.63 1264.4 1411.9699999999998 True False 1818.4722734237137 1932.0751602962275 1680.6290635273876 1791.982902657652 1659.974549738748 1503.3242627784778 1678.3334767257888 1800.5718039550243 2145.5944518777865 1593.210103252485 1.141388866233878 1.2126932639656005 1.054869699919954 1.124762452233625 1.041905613296053 0.9435819291564194 1.0534288436280483 1.1301533930014738 1.3467115526681808 1.0 10.637720818275493 -10.52134039196301 13.50636821245076 1.0000000084505605 1.1091141515659757 0.09892127382720217 0.10337869802992444 0.0 0.0 0.10553631911311857 0.02559631712013411 3.010645411149306e-11 10.52134039196301 0.10911414311541523 DTGS(ph)PPASEGPTDGSR ddPTM_A459_Selumetinib_30min_R2 1 DTGSPPASEGPTDGSR 16 0 Q969R8 Q969R8 ITFG2 Integrin-alpha FG-GAP repeat-containing protein 2 1 DT(0.011)GS(0.988)PPASEGPTDGSR 155.56 9.0211e-05 6529700.0 8319.5 8406.8 8095.2 10771.0 12631.0 6837.5 9602.2 7111.5 7965.0 9738.4 True False 7857.1354955972265 9051.57452787748 7574.363645387336 9303.97121898862 11044.180857427298 7779.303560354856 10048.721326398332 7132.193287627797 9558.222560694538 9457.227088598127 0.8308075318472566 0.9571066067336257 0.8009074514578571 0.9837948409006403 1.1678032846163167 0.8225776422069617 1.0625441508656723 0.7541526941048662 1.0106791844110599 1.0 13.207201524045962 -5.784445290022468 24.906494234567276 0.9671555680348658 0.8723571012234441 0.15517560676784992 0.11528023752058886 457.8859843327608 495711.39002314134 0.031947815972413265 0.04742087237857514 1.6426865830625484e-06 5.784445290022468 -0.09479846681142168 DTGSEVPSGSGHGPCT(ph)PPPAPANFEDVAPTGSGEPGAT(ph)RESPK ddPTM_A459_Selumetinib_30min_R2 2 DTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPK 43 1 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 2 DT(0.001)GS(0.001)EVPS(0.001)GS(0.003)GHGPCT(0.833)PPPAPANFEDVAPT(0.091)GS(0.104)GEPGAT(0.483)RES(0.483)PK;DT(0.017)GS(0.016)EVPS(0.059)GS(0.059)GHGPCT(0.82)PPPAPANFEDVAPT(0.049)GS(0.053)GEPGAT(0.464)RES(0.464)PK 47.795 0.0048227 12500000.0 32231.0 21586.6 37173.0 41154.0 41478.0 28030.2 29092.0 32489.0 26910.7 38721.0 True False 30439.73005091584 23242.222808141036 34781.3296509022 35548.75420539022 36267.16282197523 31891.105617178608 30444.835644704373 32583.537611156502 32293.591947781864 37603.024120759896 0.8095021813447887 0.6180945110558131 0.9249609696072317 0.9453695556832741 0.9644746312292696 0.8480994910080157 0.8096379574933276 0.8665137544926278 0.8588030538201634 1.0 15.198561070935929 -5.274788039577678 24.9938496267401 0.8959883493391013 0.7137983430123702 0.5350051184201452 0.07007595943838764 529.8632069980807 992108.8698920725 0.01861138624259761 0.0391058835829227 5.3114360929024405e-06 5.274788039577678 -0.1821900063267311 DTHDQLSEPSEVR ddPTM_A459_Selumetinib_30min_R1 2 DTHDQLSEPSEVR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 203.88 6.8755e-05 48012000.0 10285.5 11647.900000000001 11368.1 12219.599999999999 12262.2 10955.7 11101.9 10559.5 5539.799999999999 8713.599999999999 False True 10525.13213790093 10284.158453038206 9824.374460503472 10085.67625030074 11153.086175067252 10845.495604979702 10264.474744809035 10279.427757910002 9400.635989016573 9832.075437651545 1.0704893595095244 1.045980425827026 0.9992167495869099 1.025793212659663 1.134357262186674 1.1030728632784188 1.043978436689128 1.045499276637498 0.9561191885303492 1.0 13.263280269647302 -8.144048235537447 4.5387761995435 0.9788441120231752 1.059706796707241 0.4309976422817198 0.03721031747948008 0.23694662371266137 7.502998974561671 0.030450454110259567 0.010696813016771153 7.177145728494326e-09 8.144048235537447 0.08086268468406588 DTHDQLSEPSEVR ddPTM_A459_Selumetinib_30min_R2 2 DTHDQLSEPSEVR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 161.25 0.00051103 15628500.0 68886.0 52702.0 65560.0 73052.0 79630.0 61412.0 52637.0 60827.0 51296.0 60528.0 False True 65057.59189250685 56744.07393636091 61341.94097633084 63102.19157827096 69626.16749876775 69870.9455573694 55084.72479823678 61003.99649954807 61556.63332999205 58780.399369369436 1.106790572886248 0.9653570670690329 1.043578159291926 1.0735243764123457 1.1845133453627072 1.1886776256538887 0.9371274334509119 1.0378288877590947 1.0472306073182163 1.0 15.843047540618509 -7.27426085292967 24.976163273520786 1.0086991492159743 1.0888316583675592 0.2934317278635462 0.06671304350918526 1292.1712594035287 2517132.079572275 0.031045006224325194 0.021085345074945906 5.317887518180131e-08 7.27426085292967 0.08013250915158499 DTHEDHDT(ph)STENTDESNHDPQFEPIVSLPEQEIK ddPTM_A459_Selumetinib_30min_R1 1 DTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIK 34 0 C9JJ34;P43487-2;P43487 C9JJ34 RANBP1 Ran-specific GTPase-activating protein 1 DT(0.004)HEDHDT(0.437)S(0.262)T(0.262)ENT(0.017)DES(0.017)NHDPQFEPIVSLPEQEIK 66.399 9.9598e-05 8633500.0 921.53 1079.7 788.29 997.96 1263.9 1044.7 1159.6 1070.9 306.17 838.33 True False 942.9998560147629 953.2882220610879 681.2445477670219 823.6850200293076 1149.5804681596685 1034.1912665117063 1072.1304384006835 1042.4962532265563 519.5481282279515 945.9378215257103 0.9968941240702177 1.0077704901613111 0.7201789930211664 0.8707602141341381 1.215281218278704 1.093297300285183 1.1334047693234595 1.1020769330748466 0.5492413099520308 1.0 9.885601545089207 DTHEDHDT(ph)STENTDESNHDPQFEPIVSLPEQEIK ddPTM_A459_Selumetinib_30min_R2 1 DTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIK 34 0 C9JJ34;P43487-2;P43487 C9JJ34 RANBP1 Ran-specific GTPase-activating protein 1 DT(0.055)HEDHDT(0.296)S(0.296)T(0.296)ENT(0.039)DES(0.018)NHDPQFEPIVSLPEQEIK 51.094 0.0022912 14165000.0 22944.0 19761.0 41886.0 45589.0 56662.0 35949.0 22712.0 32367.0 31056.0 51382.0 True False 21668.86433210922 21276.60515837025 39191.100362028614 39379.699554588486 49543.61299529296 40900.648437469375 23768.153002974206 32461.182611354696 37268.06777714119 49898.46815353131 0.43425910922629635 0.42639796261690466 0.7854169038104042 0.7891965627766789 0.9928884558711001 0.8196774360211465 0.4763303139856436 0.6505446722627982 0.7468779935783205 1.0 15.606707906109461 -5.260057609027756 24.605316778362273 0.7682655232851567 0.43032849071929147 0.48740041684520774 0.14391125321975742 87.74753649388718 1562475.5199315397 0.040061318890970934 0.09488184922820407 5.494679822665016e-06 5.260057609027756 -0.33793703256586527 DTHEDHDTS(ph)TENTDESNHDPQFEPIVSLPEQEIK ddPTM_A459_Selumetinib_30min_R1 1 DTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIK 34 0 C9JJ34;P43487-2;P43487 C9JJ34 RANBP1 Ran-specific GTPase-activating protein 1 DTHEDHDT(0.017)S(0.397)T(0.397)ENT(0.081)DES(0.107)NHDPQFEPIVSLPEQEIK 89.024 6.424300000000001e-09 10278000.0 2947.9 2414.0 3114.0 2962.7 4258.2 2564.8 3385.8 2789.9 918.22 1752.2 True False 3016.58033438512 2131.3677577618478 2691.135903977606 2445.3200617668344 3873.0465618462717 2539.0004406520757 3130.406380076783 2715.902789127623 1558.1522758646167 1977.1119378733313 1.525750907978375 1.078020782199333 1.3611449369287156 1.2368141706721616 1.9589414679334198 1.284196606178574 1.5833227851752218 1.3736717365881506 0.7880951230007918 1.0 10.949178838907288 -8.216148456731286 6.642245103325928 0.8947020886014099 1.4250995170663936 0.4628220088693672 0.229038601956832 0.17625944398103469 20.72067989905889 0.161711442357063 0.05859899755387662 6.0792715542919605e-09 8.216148456731286 0.5303974284649837 DTHEDHDTS(ph)TENTDESNHDPQFEPIVSLPEQEIK ddPTM_A459_Selumetinib_30min_R2 2 DTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIK 34 0 C9JJ34;P43487-2;P43487 C9JJ34 RANBP1 Ran-specific GTPase-activating protein 1 DT(0.01)HEDHDT(0.112)S(0.323)T(0.323)ENT(0.112)DES(0.112)NHDPQFEPIVS(0.009)LPEQEIK;DT(0.082)HEDHDT(0.077)S(0.34)T(0.34)ENT(0.073)DES(0.073)NHDPQFEPIVS(0.016)LPEQEIK 41.418 0.018993 22955000.0 19589.6 17885.1 32632.0 38075.0 42025.0 30346.0 25273.0 29147.0 32248.0 37072.0 True False 18500.888455382108 19256.829660339426 30532.492647035237 32889.11931696147 36745.44379173322 34525.88604643926 26448.244577499452 29231.81294445438 38698.50108440394 36001.635035376414 0.5138902285188579 0.5348876416700803 0.8480862776658056 0.9135451566197902 1.0206604159957156 0.9590088342519156 0.7346400948598729 0.8119579267922199 1.0749095435909368 1.0 15.135774808433954 -5.30317752191788 3.09776774419754 0.9182724981489223 0.5088270683547313 0.7425086868167095 0.09416634973699024 0.1319529281416034 2.5222800528663925 0.02697296000827156 0.07306608744738151 4.975336718819819e-06 5.30317752191788 -0.40944542979419096 DTHPGSPGS(ph)PGPALRPLPAR ddPTM_A459_Selumetinib_30min_R1 2 DTHPGSPGSPGPALRPLPAR 20 1 Q8N0Y2-2;Q8N0Y2 Q8N0Y2-2 ZNF444 Zinc finger protein 444 1 DTHPGS(0.004)PGS(0.996)PGPALRPLPAR;DTHPGSPGS(0.999)PGPALRPLPAR 116.04 0.00014765 41549000.0 3281.3 3780.3999999999996 4149.5 4131.8 4055.1000000000004 3496.0 3700.3 3619.7 1866.15 2864.6 True False 3357.747905701651 3337.789010539718 3586.020691571954 3410.2586934918136 3688.316920986055 3460.833414114029 3421.183391871381 3523.693797557351 3166.7202517966884 3232.2993135669094 1.0388109453874512 1.0326361165038267 1.1094333611124354 1.055056590575618 1.141081491279321 1.070703260551365 1.0584364441472576 1.0901508355885772 0.9797113276313966 1.0 11.658345083681459 -8.263394708089818 24.99351969732662 0.9898556531873322 1.0752091475433772 0.5396556104577337 0.031280308649563854 137.6832301441689 1759829.4454857365 0.026132503836009645 0.008011420503185252 5.452620749562722e-09 8.263394708089818 0.085353494356045 DTHPGSPGS(ph)PGPALRPLPAR ddPTM_A459_Selumetinib_30min_R2 3 DTHPGSPGSPGPALRPLPAR 20 1 Q8N0Y2-2;Q8N0Y2 Q8N0Y2-2 ZNF444 Zinc finger protein 444 1 DT(0.001)HPGS(0.016)PGS(0.983)PGPALRPLPAR;DTHPGS(0.001)PGS(0.999)PGPALRPLPAR;DTHPGS(0.015)PGS(0.984)PGPALRPLPAR 105.39 0.00027353 38882300.0 110855.0 109665.0 121772.0 149829.0 130876.0 107826.0 124036.0 115454.0 92910.0 101692.0 True False 104694.12288772533 118075.95287144739 113937.32209532868 129422.0317305584 114434.186833715 122678.05275302708 129803.91977267129 115789.9520255615 111494.596122301 98755.88773245296 1.0601304417551296 1.1956345650128313 1.1537268785837347 1.3105247160674147 1.1587581202625337 1.2422353296583537 1.3143917061870063 1.1724865695021325 1.1289918877987248 1.0 16.591579142401983 -8.580651040942248 2.0923061085472683 1.0012829422889848 1.2070863531828713 0.42643784926146067 0.07160180621398939 0.35990084153859275 3.591891011771306 0.06924973614448415 0.019183070695409685 2.626327971136991e-09 8.580651040942248 0.20580341089388643 DTIEEHR ddPTM_A459_Selumetinib_30min_R2 2 DTIEEHR 7 0 P23381-2;P23381 P23381-2 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 ; 126.28 0.0080854 11447800.0 114321.0 96843.0 86718.0 93114.0 97209.0 97369.0 157370.0 264250.0 140851.0 227033.0 False True 107967.49648322265 104270.54670067545 81138.65829141966 80431.71256939051 84996.73636051382 110780.69592222203 164688.01682273927 265018.9237510577 169025.13570576056 220477.96738742536 0.48969744125725473 0.4729295536249685 0.36801254679948253 0.3648061233622286 0.3855112479840536 0.5024569903057816 0.7469590670406916 1.2020199881712657 0.7666305060257946 1.0 17.750274967275985 -7.382892989092459 2.69162371055627 0.9887350923468948 0.41871301030300007 0.8393457665068671 0.11019311887733052 0.09879810733639682 1.3875078122393816 0.05104123362902922 0.03135766991070398 4.1410169762067e-08 7.382892989092459 -0.5700220820438948 down DTIIDVVGAPLT(ph)PNSR ddPTM_A459_Selumetinib_30min_R1 4 DTIIDVVGAPLTPNSR 16 0 Q9NPF5 Q9NPF5 DMAP1 DNA methyltransferase 1-associated protein 1 1 DTIIDVVGAPLT(1)PNSR;DTIIDVVGAPLT(0.998)PNS(0.002)R;DT(0.019)IIDVVGAPLT(0.981)PNS(0.001)R;DTIIDVVGAPLT(0.998)PNS(0.002)R 235.72 5.141e-16 218598000.0 13181.400000000001 18521.800000000003 17838.0 19124.4 16417.199999999997 15540.5 17674.600000000002 13822.4 8018.9 12722.399999999998 True False 13488.500973460432 16353.25904544878 15415.697577120261 15784.682549449355 14932.26715869207 15384.17667964503 16341.390692097897 13455.785050517088 13607.487622716537 14355.44396667027 0.9396087647847979 1.1391677668358384 1.07385724975916 1.099560737104155 1.0401814944463605 1.071661504538851 1.138341017528855 0.9373297741092534 0.9478973728927995 1.0 13.809310328597435 -7.775281628957404 24.999581841313162 0.9569601350958923 1.0742909391083806 0.4528443676600904 0.05529896517074781 199.30402426252365 359944.68704247114 0.028485468985454548 0.013795043742805239 1.6777157092013377e-08 7.775281628957404 0.1173308040124883 DTIIDVVGAPLT(ph)PNSR ddPTM_A459_Selumetinib_30min_R2 2 DTIIDVVGAPLTPNSR 16 0 Q9NPF5 Q9NPF5 DMAP1 DNA methyltransferase 1-associated protein 1 1 DTIIDVVGAPLT(1)PNSR;DTIIDVVGAPLT(0.999)PNS(0.001)R 214.54 2.7217e-08 82064000.0 96337.0 96768.0 117519.0 108112.0 125717.0 84286.0 82388.0 93355.0 82404.0 114590.0 True False 90982.97520756647 104189.79444183834 109957.95548501254 93386.95909639745 109923.30653576009 95895.63142787128 86219.20524872497 93626.64759424786 98887.10256013488 111281.48895942463 0.8175930791215474 0.9362724691779415 0.9881064363283756 0.8391958084821108 0.9877950732294769 0.8617392912745503 0.7747847917470096 0.8413497021807996 0.8886213105594859 1.0 16.763854102988255 -6.959123857348184 24.999775311114718 0.856581365153837 0.915999930754241 0.046971758879908454 0.0740714479350671 308.78286584072504 188850.05404226406 0.025255196239291417 0.02227297660157083 1.0986924563566091e-07 6.959123857348184 0.05941856560040404 DTIIDVVGAPLTPNS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 DTIIDVVGAPLTPNSR 16 0 Q9NPF5 Q9NPF5 DMAP1 DNA methyltransferase 1-associated protein 1 1 DTIIDVVGAPLT(0.414)PNS(0.586)R 87.99 0.030474 0.0 11052.0 9897.6 12721.0 14088.0 13921.0 10414.0 8153.4 10792.0 7843.0 11717.0 True False 10437.774084661409 10656.71409419995 11902.544709577569 12169.190096844462 12172.119524680966 11848.433971120363 8532.549255655596 10823.40293328823 9411.819151729724 11378.69976557795 0.917308154683634 0.9365493697652432 1.0460373289384362 1.0694710597477797 1.0697285081291286 1.041281887669048 0.7498703218682041 0.951198568928801 0.8271436408052265 1.0 13.474048091067052 -7.227820149081144 24.903040465342468 0.8779862925939057 1.0164961613386378 0.3973617875089067 0.07912196984469032 597.256150112174 442410.8249496594 0.030509421878586997 0.02363111416842852 5.9180666362154156e-08 7.227820149081144 0.13850986874473215 DTLQTVS(ph)SSPVTEISR ddPTM_A459_Selumetinib_30min_R2 1 DTLQTVSSSPVTEISR 16 0 Q5T3J3 Q5T3J3 LRIF1 Ligand-dependent nuclear receptor-interacting factor 1 1 DTLQTVS(0.771)S(0.114)S(0.114)PVT(0.001)EISR 145.82 0.00067265 0.0 11331.0 10235.0 12705.0 16860.0 14247.0 10416.0 7541.3 10713.0 8875.3 11932.0 True False 10701.268381586893 11019.991589287956 11887.57413215809 14563.638914877743 12457.164490204003 11850.709452966166 7891.985392802457 10744.173056367383 10650.607996601662 11587.492156940863 0.9235189320216173 0.9510247290814366 1.0258970596185024 1.2568413180028932 1.0750526793446162 1.022715639627651 0.6810779490431144 0.9272216033330097 0.919146943303171 1.0 13.500280741904346 -7.029311569696173 24.529451082680573 0.8723824386504556 1.0514268065227261 0.3261817604002446 0.11310348158725746 654.7891256313777 547959.7233758672 0.04543534440920501 0.03526258098095346 9.347348400578963e-08 7.029311569696173 0.17904436787227052 DTPGCATT(ph)PPHSQASSVR ddPTM_A459_Selumetinib_30min_R2 1 DTPGCATTPPHSQASSVR 18 0 Q15572-5;Q15572-4;Q15572-2;Q15572-6;Q15572 Q15572-5 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 DTPGCAT(0.014)T(0.985)PPHSQASSVR 80.382 0.015335 5874500.0 8763.0 7698.2 10260.0 10922.0 12468.0 8288.4 8096.3 9074.8 6094.3 11996.0 True False 8275.987541068396 8288.627186385595 9599.882770243366 9434.404758499091 10901.658374665782 9430.051865396004 8472.793992514098 9101.206165585982 7313.3302889693305 11649.64431064889 0.7104068862860776 0.7114918675078342 0.8240494314035112 0.8098448765405775 0.935793238313776 0.8094712262395887 0.7273006597093401 0.7812432657078301 0.6277728395779644 1.0 13.507998286437873 -5.254610487929068 22.7397779782451 0.807502853389114 0.7109493225465434 0.1523134191340395 0.09655161819694852 308.4657960184551 1027142.5623089636 0.02464575639255639 0.06181456104444978 5.564030629389281e-06 5.254610487929068 -0.09655353084257057 DTPGHGSGWAET(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 DTPGHGSGWAETPR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 DTPGHGS(0.007)GWAET(0.993)PR;DTPGHGSGWAET(1)PR;DTPGHGSGWAET(1)PR 150.12 0.00099865 20868200.0 6576.1 8481.2 6777.0 7167.7 11482.1 7764.400000000001 11550.7 6967.9 3675.6000000000004 5059.0 True False 6729.310335136874 7488.217161197091 5856.720623396347 5915.995749392829 10443.546082329398 7686.297185511142 10679.421399478084 6783.088657070987 6237.224744797528 5708.371928832993 1.1788493144861707 1.3117955968100288 1.025987916767309 1.0363718102373687 1.8295139511809024 1.3464955124398335 1.8708348952415512 1.188270270689546 1.0926451223847728 1.0 12.478863621298139 DTPGHGSGWAET(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 DTPGHGSGWAETPR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 DTPGHGSGWAET(1)PR;DTPGHGSGWAET(1)PR 109.54 0.0061471 18358100.0 31479.0 27995.0 44447.0 71984.0 81190.0 52836.0 35861.0 43881.0 53960.0 52410.0 True False 29729.5232004213 30142.126481887302 41587.32841023459 62179.655020673745 70990.18635219075 60113.67940254617 37528.60755722343 44008.68644510937 64753.50776837127 50896.7871224665 0.5841139466993646 0.5922206132453924 0.8170914268157686 1.2216813385697354 1.3947871833515944 1.1810898644329402 0.7373472802305397 0.8646653145161567 1.2722513822446808 1.0 15.63528696809441 -5.524836557759828 3.6770221023974834 1.09040635398242 0.599488724635742 0.5551073659544536 0.1839659215161145 0.18690263216548958 5.484845240443198 0.057122512591900196 0.11599385131966274 2.9865063482537023e-06 5.524836557759828 -0.49091762934667804 DTPRPDHPPHDGHS(ph)PASR ddPTM_A459_Selumetinib_30min_R2 3 DTPRPDHPPHDGHSPASR 18 1 Q9C0J8 Q9C0J8 WDR33 pre-mRNA 3 end processing protein WDR33 1 DTPRPDHPPHDGHS(0.992)PAS(0.008)R;DTPRPDHPPHDGHS(0.902)PAS(0.098)R;DTPRPDHPPHDGHS(0.908)PAS(0.091)R 85.397 0.0032761 51972900.0 16763.6 18869.7 18114.5 25387.5 25475.2 15889.88 17503.5 17615.9 18370.8 21474.7 True False 15831.946222007771 20316.94531435145 16949.03279157635 21929.678704119742 22274.777624822415 18078.566736030916 18317.447432527268 17667.15935253076 22045.473323039183 20854.66961302865 0.7591559356143908 0.9742156404941911 0.812721232514165 1.05154764429447 1.0680954451997922 0.866883392136627 0.8783379344971118 0.8471560413257979 1.0571000995032112 1.0 14.348082836278111 -4.218649681917989 2.017828941258799 0.9451451572640694 1.4380347290252991e-13 0.2757776753136788 0.09057919894296773 10.565044189828077 9.037960894426332 0.0246439167372978 32.71829796796567 6.044359933402892e-05 4.218649681917989 -0.9451451572639257 DTPRPDHPPHDGHSPASR ddPTM_A459_Selumetinib_30min_R2 2 DTPRPDHPPHDGHSPASR 18 1 Q9C0J8 Q9C0J8 WDR33 pre-mRNA 3 end processing protein WDR33 0 ; 90.453 0.0023881 1566540.0 3272.4 2306.3 6185.6 7340.700000000001 6998.9 5831.7 3436.4 5064.2 4827.469999999999 7247.299999999999 False True 3090.5331084551176 2483.1857940766818 5787.625230372061 6340.883996586185 6119.635611040128 6634.9637400982 3596.1994090974194 5078.935983576559 5793.0988907816745 7038.051618253224 0.43911770985592147 0.3528229016730321 0.8223334445802905 0.9009430934182223 0.8695070657295012 0.9427273484170515 0.5109651938003207 0.7216394904527713 0.8231111684030907 1.0 12.780960379756323 -5.264154339060476 24.863296824547074 0.8114093895384648 0.3959702807505004 0.6366539181082207 0.12903777545330836 133.691239202835 1224343.4469674916 0.03520899843410221 0.07900824585037051 5.443091825118763e-06 5.264154339060476 -0.41543910878796436 DTPSSSMS(ph)SPNGNSSVNR ddPTM_A459_Selumetinib_30min_R2 1 DTPSSSMSSPNGNSSVNR 18 0 Q9H9J4-2;Q9H9J4;C9JPC9;E7EWZ4 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 DTPSSSMS(0.471)S(0.471)PNGNS(0.053)S(0.004)VNR 169.58 9.5885e-08 2054500.0 5507.0 5790.7 7019.1 6772.9 7167.8 5223.8 7450.5 6404.1 6464.6 6728.8 True False 5200.942986267678 6234.828069964809 6567.498747818243 5850.419336095816 6267.316883054973 5943.331033064968 7796.963012885677 6422.7348707441715 7757.700636015811 6534.522060478011 0.7959178862864258 0.954136815555983 1.0050465339369932 0.8953094475692762 0.9591086884472938 0.9095280386321328 1.1931956064611275 0.9828928284732638 1.187187152207475 1.0 12.67386600481537 -7.24066964169366 24.950664179753897 1.0893933021727236 0.925942884699796 0.5146829354685855 0.081202640163779 642.9842173504212 772417.3880641826 0.02932032891079266 0.022683021249798284 5.7455334617656565e-08 7.24066964169366 -0.16345041747292754 DTPTSAGPNS(ph)FNK ddPTM_A459_Selumetinib_30min_R2 2 DTPTSAGPNSFNK 13 0 Q8WW12;Q8WW12-3 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 DTPT(0.018)S(0.094)AGPNS(0.889)FNK;DTPTSAGPNS(1)FNK 172.43 0.00017592 9390500.0 49480.0 54269.0 61247.0 56563.0 50300.0 36847.0 46185.0 43828.0 34744.0 40134.0 True False 46730.099684133755 58431.25779766175 57306.43470069151 48859.02182338255 43980.86431229459 41922.339786237004 48332.694013841305 43955.53222388403 41693.77082847095 38975.22713934497 1.1989692713544278 1.4991896670353506 1.4703297172793492 1.2535917147756663 1.128431250831544 1.0756150217253504 1.2400875520504688 1.1277812972515433 1.0697505540995718 1.0 15.250269810217262 -6.03010974247257 3.245270317865557 1.119308496866233 1.3992749743319537 0.6398625547391279 0.09478021414695115 0.1560572561220094 3.3591742464452574 0.02849609580244833 0.04085035700193993 9.330185052715209e-07 6.03010974247257 0.2799664774657207 DTQSPS(ph)TCSEGLLGWSQK ddPTM_A459_Selumetinib_30min_R1 1 DTQSPSTCSEGLLGWSQK 18 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DT(0.023)QS(0.058)PS(0.451)T(0.451)CS(0.016)EGLLGWSQK 105.66 0.0017159000000000002 13437000.0 1019.6 1706.4 1178.5 1092.6 1637.8 1268.5 1587.8 1334.6 957.86 1203.0 True False 1043.3546962037613 1506.6138947161617 1018.4661730371251 901.7979206421311 1489.6612791770747 1255.7400417058473 1468.030967654886 1299.2020726082383 1625.4184606735655 1357.416768212313 0.7686325383896913 1.1099125412310458 0.7502973271638761 0.6643485934167283 1.0974236609283416 0.925095424715895 1.0814887527787427 0.9571136168586292 1.1974350831205693 1.0 10.406648024666945 -6.28419782359314 24.900438239102556 1.0369683772109468 0.8385558915678347 0.40547377710857324 0.12973317491252967 862.5824907696034 943764.9792291161 0.04059880078846345 0.04606567125090578 5.197591893532815e-07 6.28419782359314 -0.1984124856431121 DTQSPS(ph)TCSEGLLGWSQK ddPTM_A459_Selumetinib_30min_R2 2 DTQSPSTCSEGLLGWSQK 18 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DT(0.004)QS(0.056)PS(0.939)T(0.001)CSEGLLGWSQK;DT(0.016)QS(0.247)PS(0.565)T(0.172)CSEGLLGWSQK 168.16 1.1855e-07 14278300.0 89109.0 83056.0 97372.0 102253.0 106491.0 90965.0 92545.0 97252.0 84759.0 94390.0 True False 84156.67851158997 89426.12813286751 91107.19153061752 88325.96500373632 93112.64853838104 103494.60305194586 96848.52587443858 97534.98721906458 101713.16836433261 91664.71544532772 0.9180923990516741 0.9755785276637292 0.9939177914642333 0.9635764925972768 1.0157959699762218 1.1290560664389335 1.0565518629925021 1.0640406916141918 1.109621819804788 1.0 16.484078882745933 -6.5234559896279505 4.775569495847449 1.075226513028578 0.9677609741206867 0.6596113397390048 0.0367939836365808 0.11319308457820436 7.075714228271302 0.011713258957857334 0.012358016047078844 2.9960151861132783e-07 6.5234559896279505 -0.10746553890789134 DTQSPSTCS(ph)EGLLGWSQK ddPTM_A459_Selumetinib_30min_R2 1 DTQSPSTCSEGLLGWSQK 18 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DT(0.088)QS(0.116)PS(0.207)T(0.207)CS(0.375)EGLLGWS(0.007)QK 106.31 0.0016701 15280000.0 47802.0 37291.0 52736.0 54847.0 50107.0 44899.0 54043.0 46711.0 47246.0 47241.0 True False 45145.35620656755 40151.09979053611 49343.0231746154 47376.743983647684 43812.1106977365 51083.42969745853 56556.10658417293 46846.92127657765 56696.5201635372 45877.02958314142 0.9840514221774563 0.8751896135248164 1.0755496513825655 1.032689875829654 0.9549901354955265 1.1134859898651834 1.2327761212542798 1.0211411179461505 1.235836772317353 1.0 15.485484363222223 -6.813638385603882 6.7091041221704035 1.1300993932629964 0.9862456005037011 0.38272731660388004 0.08611097178127473 0.21054179928170866 20.617533697412988 0.02938051452888654 0.02610903543056993 1.535895310559434e-07 6.813638385603882 -0.14385379275929522 DTS(ph)GLER ddPTM_A459_Selumetinib_30min_R2 1 DTSGLER 7 0 Q9H307 Q9H307 PNN Pinin 1 DT(0.019)S(0.981)GLER 82.287 0.041442 52073000.0 175050.0 139420.0 114860.0 177420.0 170300.0 135270.0 161800.0 205200.0 141650.0 185480.0 True False 165321.42178067117 150113.0656940426 107470.03265011261 153255.0899334286 148905.39149868334 153902.21464119956 169324.0206006177 205797.09802731127 169983.95803168605 180124.71046508497 0.9178164470261106 0.8333840776562427 0.5966423616872067 0.8508276823192189 0.8266794217973046 0.8544203304689374 0.9400377114468097 1.142525628471184 0.9437014921094651 1.0 17.458636585831023 -7.287551456862254 2.1096833951833607 1.0333534144480643 0.7989989431873705 0.5317695246757432 0.09131936091351342 0.25213370763376747 2.1926046431317583 0.04717726667414918 0.029750287512680742 5.1576105212054045e-08 7.287551456862254 -0.23435447126069375 DTS(ph)PSSGSAVSSSK ddPTM_A459_Selumetinib_30min_R1 5 DTSPSSGSAVSSSK 14 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-7 F8WF16 PPHLN1 Periphilin-1 1 DT(0.088)S(0.912)PSSGSAVSSSK;DT(0.195)S(0.648)PS(0.112)S(0.034)GS(0.008)AVS(0.002)SS(0.001)K;DT(0.068)S(0.93)PS(0.001)SGSAVSSSK;DT(0.067)S(0.933)PSSGSAVSSSK;DT(0.004)S(0.996)PSSGSAVSSSK 250.81 1.6307999999999995e-27 1085866400.0 34429.340000000004 40052.3 34960.07 35654.7 33362.97 28040.19 35019.3 32159.98 17762.010000000002 26856.17 True False 35231.476634166334 35362.95809619088 30212.68451591853 29428.27596661084 30345.29525421075 27758.131147055497 32377.766006799804 31306.99286006254 30140.833684117195 30303.42102074852 1.1626237384235798 1.166962570726854 0.9970057339477327 0.9711205855755205 1.0013818318873489 0.916006517153615 1.0684525019347155 1.0331174436914856 0.9946346870698195 1.0 14.887193051500777 -5.261749268395206 24.93512125157653 0.9976870248884455 1.1647931678077679 0.765545938310901 0.036984785729382685 11.800524358947976 949616.5617267985 0.009970112401383817 0.023081170049925954 5.473318632685667e-06 5.261749268395206 0.16710614291932235 DTS(ph)PSSGSAVSSSK ddPTM_A459_Selumetinib_30min_R2 6 DTSPSSGSAVSSSK 14 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-7 F8WF16 PPHLN1 Periphilin-1 1 DT(0.003)S(0.971)PS(0.018)S(0.006)GS(0.002)AVSSSK;DT(0.445)S(0.554)PS(0.001)SGSAVSSSK;DT(0.158)S(0.84)PS(0.002)SGSAVSSSK;DT(0.229)S(0.77)PS(0.001)SGSAVSSSK;DTS(0.999)PS(0.001)SGSAVSSSK;DT(0.211)S(0.788)PS(0.001)SGSAVSSSK 183.06 7.6666e-05 99091400.0 179095.0 163782.0 186989.0 199499.0 200601.0 156757.9 156795.0 169937.0 140323.0 170788.0 True False 169141.61687408923 176343.55275786595 174958.33131822932 172326.89204502906 175399.70898430614 178349.8778184646 164086.27818339848 170431.48853541515 168391.5209522082 165856.90667948528 1.0198044824322665 1.0632270689736538 1.054875162095796 1.039009441904321 1.057536357670423 1.0753237919908978 0.9893243607906633 1.027581497493922 1.0152819338275794 1.0 17.339579565096194 -7.263363041924053 24.998692405871484 1.0103454063532724 1.0519989520237107 0.6196539173898254 0.0166872120736245 125.34765823401993 1628931.1647285298 0.006633270409132936 0.004741035893392328 5.453018336671603e-08 7.263363041924053 0.04165354567043833 DTSATSQSVNGS(ph)PQAEQPSLESTSK ddPTM_A459_Selumetinib_30min_R1 3 DTSATSQSVNGSPQAEQPSLESTSK 25 0 C9J0I9;Q86WB0;Q86WB0-2;Q86WB0-3;F8WAU5 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 DTSATSQS(0.001)VNGS(0.999)PQAEQPSLESTSK;DTSATSQSVNGS(1)PQAEQPSLESTSK;DTSATSQSVNGS(1)PQAEQPSLESTSK 190.8 6.9927e-27 21967300.0 6465.599999999999 7681.1 7743.4 8114.4 7129.1 6655.4 7059.6 6207.1 3912.6499999999996 5557.5 True False 6616.235900132442 6781.7932411534875 6691.888811451566 6697.3723661527665 6484.274163744834 6588.452718619703 6527.08868828343 6042.467544497673 6639.481281350539 6270.859259634189 1.0550764458582986 1.0814775073662082 1.0671406476186707 1.0680150979091594 1.0340328008131847 1.050645923602508 1.0408603379601584 0.963578880392567 1.0587833351785116 1.0 12.61444742540522 -6.966686227985721 0.8819923671699142 1.0083630298364892 1.0698984905287154 0.4539866191111327 0.024919894672791446 0.5070864230789084 0.8258010090943917 0.016482486759336133 0.012485155131897503 1.0797265286202504e-07 6.966686227985721 0.06153546069222626 DTSATSQSVNGS(ph)PQAEQPSLESTSK ddPTM_A459_Selumetinib_30min_R2 2 DTSATSQSVNGSPQAEQPSLESTSK 25 0 C9J0I9;Q86WB0;Q86WB0-2;Q86WB0-3;F8WAU5 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 DTSATSQSVNGS(1)PQAEQPSLESTSK;DTSATSQSVNGS(1)PQAEQPSLESTSK 177.92 1.3460999999999997e-20 26708000.0 97657.0 89365.0 104712.0 110282.0 109422.0 75394.0 85767.0 93415.0 77532.0 93379.0 True False 92229.61489194525 96219.00814623536 97974.94392180555 95261.40135293899 95675.43011490855 85778.83914141043 89755.33544408638 93686.82218431434 93040.56642508077 90682.9056422211 1.0170562383149313 1.0610490198214018 1.0804124904020427 1.050489071543228 1.0550547474998748 0.9459207171839078 0.9897712783730779 1.0331254994623225 1.025998954997776 1.0 16.468542997893955 -6.6553587047283465 24.999917524377835 1.000448989696215 1.0546770698440524 0.509770760509386 0.02635155755869256 8.42183044815324 1959.441856504514 0.009256813493524162 0.009256812870633941 2.2112675627698756e-07 6.6553587047283465 0.05422808014783742 DTSENADGQS(ph)DENKDDYTIPDEYR ddPTM_A459_Selumetinib_30min_R2 2 DTSENADGQSDENKDDYTIPDEYR 24 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2;Q68E03 D6REM6 MATR3;DKFZp686L22104 Matrin-3 1 DT(0.024)S(0.091)ENADGQS(0.855)DENKDDY(0.015)T(0.015)IPDEYR;DT(0.002)S(0.005)ENADGQS(0.931)DENKDDY(0.027)T(0.035)IPDEYR 58.51600000000001 0.0059982 11108300.0 33204.5 19432.0 32349.0 33449.3 29282.8 22884.5 39362.0 35887.0 25552.7 24224.5 True False 31359.126818145076 20922.37191627196 30267.700558928118 28893.447636739038 25604.032872446533 26036.632150192436 41192.41099432332 35991.42522858733 30663.954002091545 23525.075742190238 1.3330085378600982 0.8893646994194137 1.2866143722821497 1.228197858037969 1.088371963305855 1.1067608213264084 1.7510001432406956 1.5299175068771296 1.303458247622061 1.0 14.52191174746421 -7.205842410401256 24.999663867583173 1.4402550113108679 1.149522761522428 0.22591160785350273 0.21190588502340776 355.9117304866601 160038.78879877256 0.07786965591782213 0.06031755078658303 6.225261361784036e-08 7.205842410401256 -0.2907322497884399 DTSENADGQSDENKDDYT(ph)IPDEYR ddPTM_A459_Selumetinib_30min_R1 1 DTSENADGQSDENKDDYTIPDEYR 24 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2;Q68E03 D6REM6 MATR3;DKFZp686L22104 Matrin-3 1 DTSENADGQS(0.065)DENKDDY(0.179)T(0.748)IPDEY(0.008)R 57.986 0.016127000000000002 3772400.0 1069.3 1111.0 1032.8 1180.5 891.52 930.07 1126.9 1189.6 537.11 1158.2 True False 1094.2126095043955 980.9236035101125 892.5514327643133 974.3478357294858 810.8821734106399 920.7143402359941 1041.8970257276058 1158.0479436346163 911.4364410377078 1306.8662518233596 0.8372797200767358 0.7505921911607351 0.6829707565858496 0.745560484380143 0.6204783177155924 0.7045207104792854 0.7972483980468049 0.8861258311773605 0.6974213618004581 1.0 10.35189578409326 -10.705291062676755 4.31730209724518 1.0000652053885741 0.7457085295285452 0.5143061527925996 0.07377618374001431 22173132.719213102 27490542.65408939 12664.194454013179 0.018991881411082198 1.97110126801273e-11 10.705291062676755 -0.25435667586002897 DTSFTVCPDVPRT(ph)PVGK ddPTM_A459_Selumetinib_30min_R2 1 DTSFTVCPDVPRTPVGK 17 1 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;A0A3B3IT42;D6RD20 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 DTSFT(0.004)VCPDVPRT(0.995)PVGK 106.44 0.025951 0.0 12674.0 12800.0 10062.0 12765.0 11079.0 11155.0 11255.0 10416.0 10700.0 13037.0 True False 11969.629818041858 13781.718841513039 9414.621874677265 11026.384979146762 9687.156972483333 12691.499994992091 11778.3798013594 10446.308835538368 12840.298982979479 12660.58793580607 0.9454244841339415 1.0885528311474573 0.7436164830901163 0.8709220326144939 0.7651427423118778 1.0024415974473506 0.9303185492711874 0.8251045597965175 1.0141945262008851 1.0 13.62805678213377 -8.28591061321881 24.11597229608803 1.0070973493470956 0.8971854683489641 0.16639379863694448 0.09906059329200732 1090.7031221882482 1074852.972530338 0.0970986110134688 0.02512958645447199 5.177133770996741e-09 8.28591061321881 -0.10991188099813154 DTSGGIDLGEEQHPLGT(ph)PTPGR ddPTM_A459_Selumetinib_30min_R1 2 DTSGGIDLGEEQHPLGTPTPGR 22 0 Q9UIF8-4;Q9UIF8-2;Q9UIF8-5;Q9UIF8-3;Q9UIF8 Q9UIF8-4 BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 1 DTSGGIDLGEEQHPLGT(0.879)PT(0.121)PGR;DTSGGIDLGEEQHPLGT(0.75)PT(0.25)PGR 158.12 6.874899999999998e-09 16874800.0 4629.0 4456.7 4941.9 5527.799999999999 5365.5 4126.9 5319.200000000001 4746.299999999999 2808.6 4313.299999999999 True False 4736.846693533943 3934.9074921363804 4270.81712391359 4562.473499657308 4880.191472355962 4085.387132925395 4917.9684614875105 4620.412705844807 4765.989067972121 4866.954070099894 0.9732671862746219 0.8084948893005716 0.8775133404589396 0.9374391937838162 1.0027198535398951 0.8394135375190714 1.0104817901818763 0.9493438070908223 0.9792549917929058 1.0 12.248803444494904 -6.853859602597489 0.4416746847582474 0.9966781128977021 0.8756650921574386 0.243468066131996 0.05931809598626246 1.726925915934744 0.71632721615019 0.058406725190957756 0.08221630741433199 1.4000398500579899e-07 6.853859602597489 -0.12101302074026354 DTSGGIDLGEEQHPLGT(ph)PTPGR ddPTM_A459_Selumetinib_30min_R2 3 DTSGGIDLGEEQHPLGTPTPGR 22 0 Q9UIF8-4;Q9UIF8-2;Q9UIF8-5;Q9UIF8-3;Q9UIF8 Q9UIF8-4 BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 1 DTSGGIDLGEEQHPLGT(0.82)PT(0.18)PGR;DTSGGIDLGEEQHPLGT(0.819)PT(0.181)PGR;DTSGGIDLGEEQHPLGT(0.847)PT(0.153)PGR 117.0 4.5205e-05 17870200.0 66926.1 51515.4 65578.9 68300.0 73664.8 52255.6 59136.5 62389.5 57114.7 56462.6 True False 63206.61528840554 55466.46553188131 61359.624970907586 58997.422175928165 64410.369252332406 59453.33457089274 61886.464426751714 62571.043115862245 68539.23591805402 54832.378030547174 1.1527243128720968 1.0115641072685355 1.1190400120294632 1.0759595752542528 1.1746776551702596 1.0842742318739345 1.128648193814879 1.1411331290611517 1.2499774472642924 1.0 15.74274042291755 -6.235634403444045 24.3247404078414 1.134509382528973 1.0863191463404407 0.07232329128386428 0.06842285877207915 1283.1487370297511 1209543.3546940284 0.019264233958422798 0.024861440294709134 5.812535208242905e-07 6.235634403444045 -0.04819023618853224 DTSGPTPGTPS(ph)PAMAR ddPTM_A459_Selumetinib_30min_R1 1 DTSGPTPGTPSPAMAR 16 0 Q9H6K5-2;Q9H6K5 Q9H6K5-2 PRR36 Proline-rich protein 36 1 DTS(0.001)GPT(0.122)PGT(0.051)PS(0.826)PAMAR 91.592 0.011458 3389000.0 1010.2 1143.7 962.73 1077.9 1613.5 1029.9 1368.6 1285.4 339.48 701.64 True False 1033.7356944929775 1009.7950723082945 831.9965538973541 889.6649996889565 1467.559209886562 1019.540141074381 1265.3654001338182 1251.3070164323615 576.0727653618088 791.702328552359 1.305712585667369 1.2754731619328716 1.0508956761800534 1.1237367475168654 1.8536755001971748 1.2877821680007275 1.5982842976444949 1.5805271391842404 0.7276380838934345 1.0 9.628814284416347 -8.265746743250299 24.999934210800284 0.8638189980624994 1.3806036482579005 0.44167447900380874 0.2341381471930755 382.1164404589117 2217759.631701014 0.21097300193485555 0.06203071693617624 5.423170478021127e-09 8.265746743250299 0.5167846501954011 DTSGPTPGTPS(ph)PAMAR ddPTM_A459_Selumetinib_30min_R2 1 DTSGPTPGTPSPAMAR 16 0 Q9H6K5-2;Q9H6K5 Q9H6K5-2 PRR36 Proline-rich protein 36 1 DTS(0.009)GPT(0.029)PGT(0.007)PS(0.956)PAMAR 127.05 0.0010702 4686400.0 13324.0 13728.0 18681.0 20201.0 22269.0 17482.0 16059.0 17790.0 18484.0 18021.0 True False 12583.505420198018 14780.893457522723 17479.08479833492 17449.588951331276 19471.36913261407 19889.98681420455 16805.775320304816 17841.76595470695 22181.31648611147 17500.686905818915 0.7190292294192205 0.8445893316683547 0.9987656423087706 0.9970802314924765 1.1126059929761904 1.136526064447859 0.9602923251382183 1.019489466369153 1.2674540494028417 1.0 14.09512392881676 -4.941664022532355 1.0102345609378605 1.0789581519233906 0.5840475534910752 0.6757184492633341 0.0820498879336898 0.8999374877619772 0.8852046676913545 0.02772180522634298 0.4566870352858215 1.1437628266501689e-05 4.941664022532355 -0.49491059843231544 DTSLDFRPVVS(ph)PANGVEGVR ddPTM_A459_Selumetinib_30min_R1 1 DTSLDFRPVVSPANGVEGVR 20 1 Q8ND24 Q8ND24 RNF214 RING finger protein 214 1 DTS(0.001)LDFRPVVS(0.999)PANGVEGVR 64.962 0.009581200000000002 12428000.0 1061.5 1621.6 837.62 1036.9 1409.5 1261.2 1513.7 1482.5 746.86 1427.0 True False 1086.230884680554 1431.7423181386123 723.8758047173158 855.8248800236373 1282.010973867436 1248.5134730779778 1399.5203903131387 1443.1792841613305 1267.3668715038305 1610.1693501570828 0.6746066086617442 0.889187412491075 0.4495650129265576 0.5315123405747015 0.7961963589372554 0.7753926460941372 0.8691758976635632 0.896290370960383 0.7871015998287325 1.0 10.652996716966632 -6.672019199451726 2.06766548774998 0.8704059226514368 0.6449883900067594 0.4381544489298137 0.12143334029133743 0.3412887450675493 2.992745713434859 0.04908956753593722 0.04794699416507906 2.1280449665010743e-07 6.672019199451726 -0.22541753264467734 DTSLDFRPVVS(ph)PANGVEGVR ddPTM_A459_Selumetinib_30min_R2 3 DTSLDFRPVVSPANGVEGVR 20 1 Q8ND24 Q8ND24 RNF214 RING finger protein 214 1 DT(0.001)S(0.001)LDFRPVVS(0.998)PANGVEGVR;DT(0.008)S(0.02)LDFRPVVS(0.973)PANGVEGVR;DT(0.052)S(0.187)LDFRPVVS(0.761)PANGVEGVR 52.158 0.033544 18730300.0 24248.5 18801.9 23267.0 25044.0 31181.7 27741.0 25787.5 30395.2 28812.4 20724.0 True False 22900.865444436487 20243.9452723628 21770.026551194176 21632.9639966903 27264.37607806513 31562.070942274833 26986.669846961857 30483.644999803757 34575.685085719444 20125.644272581492 1.137894774163124 1.005878122368608 1.0817058205114425 1.0748954768202046 1.3547082373511494 1.5682514564402765 1.3409096117100507 1.5146667896407997 1.7179914648906025 1.0 14.296747347819213 -6.345467543374696 3.43043612764757 1.455761620322296 1.0676572655690881 0.46823172164468796 0.17778865862524648 0.19850694183552833 4.487724090932972 0.054627956638874556 0.06377549170015416 4.513697568118109e-07 6.345467543374696 -0.3881043547532079 DTSLYRPALEELRR ddPTM_A459_Selumetinib_30min_R1 1 DTSLYRPALEELRR 14 2 Q13200;C9JPC0;H7C2Q3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 103.97 0.0041292 17658000.0 1921.3 2014.1 2295.3 2758.8 2471.5 1958.0 2078.7 1838.0 1382.8 1792.6 False True 1966.0625518009863 1778.2882356703124 1983.610867180411 2277.027369089797 2247.9532613787655 1938.3042977217576 1921.9019854290284 1789.250269334589 2346.5106042839307 2022.697671402655 0.9720002052692359 0.8791666005316281 0.9806759038808114 1.1257378704108436 1.111363943885843 0.9582768226442985 0.9501676956478973 0.8845861122160781 1.160089635470201 1.0 10.982064983914158 -5.518374130439491 24.961152307924237 1.0223644061447525 0.9266678494671076 0.18836185506511338 0.08407688687378786 315.6968129659876 1749349.1427817012 0.023839351578926086 0.042706127387530435 3.0312787119743124e-06 5.518374130439491 -0.09569655667764498 DTSPDKGELVS(ph)DEEEDT ddPTM_A459_Selumetinib_30min_R1 2 DTSPDKGELVSDEEEDT 17 1 Q9UPU7 Q9UPU7 TBC1D2B TBC1 domain family member 2B 1 DTSPDKGELVS(0.984)DEEEDT(0.016);DTSPDKGELVS(0.648)DEEEDT(0.352) 127.3 0.0052364 84088000.0 10420.099999999999 11125.1 13291.1 13603.5 11670.0 9952.400000000001 11139.0 9660.5 5885.9 9238.8 True False 10662.868056014913 9822.568120081323 11486.241622786372 11227.904094321098 10614.450560505844 9852.28789205619 10298.776261939645 9404.272158273554 9987.942410872716 10424.689973532775 1.0228474979195399 0.9422407903755241 1.10183052464378 1.077049209408395 1.018202995720242 0.9450916926134154 0.9879215869332506 0.9021152842098942 0.9581045034654349 1.0 13.347716858634485 -6.680062234819774 4.770790508078666 0.9543486254031245 1.035364594072653 0.39358018300595454 0.04593455370516485 0.22346199569791778 9.11323555260925 0.01629467653507263 0.016083905155010063 2.0889967541464704e-07 6.680062234819774 0.08101596866952854 DTSPDKGELVS(ph)DEEEDT ddPTM_A459_Selumetinib_30min_R2 1 DTSPDKGELVSDEEEDT 17 1 Q9UPU7 Q9UPU7 TBC1D2B TBC1 domain family member 2B 1 DTSPDKGELVS(0.836)DEEEDT(0.164) 107.5 0.01158 24956000.0 76877.0 70560.0 78370.0 84726.0 81226.0 57062.0 66265.0 66304.0 50213.0 77473.0 True False 72604.48410301442 75971.7251138406 73327.7595228045 73186.17263949757 71021.66371034665 64921.772542737715 69346.4538016065 66496.93366278194 60257.00306844382 75236.15319097198 0.9650212168440139 1.0097768412082622 0.9746346192990037 0.9727527197427155 0.9439831875783483 0.862906591967119 0.9217171646932075 0.883842818146121 0.8009048909703481 1.0 16.199138465595766 -6.513527066043019 2.8554926257547146 0.888333350308504 0.9822893483428514 0.4127406346654863 0.04831289892879789 0.24498215287007005 4.0462708332786965 0.016025618434397607 0.01719893818666343 3.0652996382759005e-07 6.513527066043019 0.0939559980343474 DTSPDKGELVSDEEEDT(ph) ddPTM_A459_Selumetinib_30min_R2 1 DTSPDKGELVSDEEEDT 17 1 Q9UPU7 Q9UPU7 TBC1D2B TBC1 domain family member 2B 1 DTSPDKGELVS(0.205)DEEEDT(0.795) 109.48 0.023131 10612000.0 53521.0 49669.0 48147.0 55415.0 59951.0 42566.0 47812.0 47388.0 31144.0 43718.0 True False 50546.51708153844 53478.45258899307 45049.274438489956 47867.38140379301 52419.419411259885 48429.08012432394 50035.35273768067 47525.89123449431 37373.6702360666 42455.74774699468 1.190569469716064 1.259628093413539 1.0610877638276637 1.1274652772351985 1.2346836928568876 1.1406954934094193 1.1785295370571474 1.1194218393635176 0.8802970674026622 1.0 15.373672261590412 -8.130845337209342 4.569489677222715 0.9429690111391649 1.1681109366091642 0.7010218583736824 0.059109077004263086 0.12284421288816312 3.887472737971905 0.04337641243002792 0.015339131855957993 7.398687133275067e-09 8.130845337209342 0.22514192546999934 DTSS(ph)SPTTGSTVQSVDLIFTR ddPTM_A459_Selumetinib_30min_R1 2 DTSSSPTTGSTVQSVDLIFTR 21 0 P57060 P57060 RWDD2B RWD domain-containing protein 2B 1 DTS(0.001)S(0.499)S(0.499)PT(0.001)TGSTVQSVDLIFTR;DTS(0.014)S(0.47)S(0.47)PT(0.046)TGSTVQSVDLIFTR 276.4 2.604199999999999e-61 10813900.0 2518.7 4041.9 2812.4 3806.0 2759.0 2799.5 2949.5 1923.85 1045.91 2080.66 True False 2577.3808094629394 3568.672468971668 2430.4915274073924 3141.3535474683795 2509.4489371410136 2771.3395717426242 2727.0168403439257 1872.8232484544867 1774.8328797560073 2347.7329783446644 1.0978168442648852 1.5200504068771319 1.0352504095764243 1.338036981396104 1.068881751156544 1.1804321859876228 1.1615532368875638 0.7977156114981073 0.7559773177473545 1.0 11.197052616140533 -7.715223345936806 5.318661566523065 0.8315533627654311 1.2086686141623277 0.5455358532875367 0.14584788483144334 0.12920863369579247 8.213124750249808 0.06945973245664294 0.03796878509233354 1.926533893972768e-08 7.715223345936806 0.3771152513968966 DTSSITSCGDGNVVKQEQLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 DTSSITSCGDGNVVKQEQLSPK 22 1 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 DTSSITSCGDGNVVKQEQLS(1)PK 113.52 2.0646e-05 4517000.0 601.23 448.71 3033.9 3085.0 1089.4 1346.6 742.63 687.01 660.6 407.93 True False 615.2374892100704 396.1748246003803 2621.9130440197996 2546.262662622164 990.8639623491912 1333.0544266149734 686.6128212051566 668.7882630770157 1120.9899516849625 460.29178907468776 1.3366249492454902 0.8607036536471787 5.696197729902072 5.531844632164409 2.152686591131896 2.896107335077119 1.491690352733504 1.4529658771916458 2.43538985116041 1.0 8.846404897018504 -7.0108526101504705 1.9835809275127574 1.6326314168362157 3.2927314428320624 0.18464816752127577 1.5134094613964029 0.6450563518589625 5.090920585349878 0.7521850662149555 0.5781680053260405 9.753205835839276e-08 7.0108526101504705 1.6601000259958467 DTSSS(ph)PTTGSTVQSVDLIFTR ddPTM_A459_Selumetinib_30min_R2 2 DTSSSPTTGSTVQSVDLIFTR 21 0 P57060 P57060 RWDD2B RWD domain-containing protein 2B 1 DTS(0.002)S(0.021)S(0.977)PTTGSTVQSVDLIFTR;DTS(0.001)S(0.008)S(0.895)PT(0.075)T(0.02)GSTVQSVDLIFTR 202.6 6.8265e-17 4436900.0 17220.0 23632.0 22382.0 20708.9 23789.4 18206.7 14289.3 15915.300000000001 12285.1 26081.0 True False 16262.98133712174 25444.49841114344 20941.966487679027 17888.312095154906 20800.762892065628 20714.507661032952 14953.780763710785 15961.61088808026 14742.463274373938 25327.973763423946 0.6420956326402654 1.004600630465267 0.8268314979827269 0.7062670019418358 0.8212564923809242 0.8178509601485261 0.5904057270189333 0.6301969133879306 0.5820624820633495 1.0 14.628444045688438 -7.240786451849873 23.671156816685468 0.6698493588976233 0.8098028520629901 0.09480696095262686 0.14207993830809335 685.0665035303396 785182.9548396362 0.05180274484236958 0.04006716432650673 5.743988320298272e-08 7.240786451849873 0.13995349316536676 DTT(ph)SPMELAALEK ddPTM_A459_Selumetinib_30min_R2 1 DTTSPMELAALEK 13 0 Q6VY07-2;Q6VY07 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 DT(0.006)T(0.607)S(0.386)PMELAALEK 178.84 0.00025218 2410100.0 30721.0 25252.0 32491.0 30531.0 26751.0 25453.0 22059.0 28861.0 19341.0 26840.0 True False 29013.64980590688 27188.747202022445 30400.564433526026 26372.625131087327 23390.300223025704 28958.91971067089 23084.78720907925 28944.98073180425 23209.74043269216 26065.05946130513 1.1131242516050683 1.0431108834562792 1.1663339758981623 1.0117999220465541 0.8973814258029897 1.1110245021179346 0.8856602549996005 1.1104897257101796 0.8904541525081947 1.0 14.66982953065668 -5.921976499431144 7.46304113666353 0.986508991333717 1.1003047414911586 0.3197737877962995 0.08137119589679899 0.27808426180615176 22.632630925247863 0.021161377269721348 0.03151507695402443 1.1968052911542368e-06 5.921976499431144 0.1137957501574417 DTTIINHS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 DTTIINHSR 9 0 Q8IY63-2;Q8IY63 Q8IY63-2 AMOTL1 Angiomotin-like protein 1 1 DTTIINHS(1)R 116.03 0.0052788 7157000.0 6115.2 8646.5 6941.6 7736.5 8249.2 7407.1 9366.1 8504.1 4155.9 7018.8 True False 6257.672261892156 7634.1637603512045 5998.9688474794275 6385.465507091199 7503.0613165145505 7332.5912991087025 8659.607536309633 8278.54364279014 7052.258765073465 7919.731348901565 0.7901369359908995 0.9639422631943232 0.7574712554247766 0.8062729940930177 0.9473883628079373 0.9258636405798921 1.0934218794568942 1.0453061193721351 0.8904669179279149 1.0 12.95123577706532 -6.597319607153717 2.003435059877333 1.0058317385105733 0.8355904425165352 0.5148164588091919 0.07369536237326658 0.2709366790543704 2.2147805051320324 0.02817075138108756 0.028964824035982495 2.5274373134604e-07 6.597319607153717 -0.17024129599403803 DTTIINHS(ph)R ddPTM_A459_Selumetinib_30min_R2 4 DTTIINHSR 9 0 Q8IY63-2;Q8IY63 Q8IY63-2 AMOTL1 Angiomotin-like protein 1 1 DTTIINHS(1)R;DTTIINHS(1)R;DTTIINHS(1)R;DTTIINHS(1)R 112.84 0.0062564 23688700.0 326357.0 243550.0 322202.0 301988.0 310291.0 216722.0 241152.0 258258.0 218870.0 232275.0 True False 308219.3844505829 262229.50186332077 301471.8741070124 260856.71344164328 271309.47054326406 246573.4882935615 252366.04583362248 259009.48802308636 262650.1157387592 225568.6172270732 1.3664107544725854 1.1625265300063534 1.336497416232018 1.1564406283478992 1.2027802177381124 1.0931196516816137 1.1187994541792714 1.1482514332317302 1.1643912126054183 1.0 17.783206837739677 -1.522878745280494 0.1309599164594104 0.981409762092939 2.080977291725443 0.6234037482407491 0.06297481402044952 55.93598007620339 0.4968660364246025 0.3213313169278317 11.365883374197033 0.0299999999999892 1.522878745280494 1.0995675296325043 DTTKLEPAS(ph)PPEDTSAEVSR ddPTM_A459_Selumetinib_30min_R1 1 DTTKLEPASPPEDTSAEVSR 20 1 E9PFE2;Q9UHL9-2;Q9UHL9;Q9UHL9-3 E9PFE2 GTF2IRD1 General transcription factor II-I repeat domain-containing protein 1 1 DTTKLEPAS(0.998)PPEDT(0.001)SAEVSR 77.89399999999998 0.0028078000000000005 9504200.0 1311.5 1546.1 2938.1 2630.3 2086.6 1776.8 1377.2 1643.8 1052.9 1269.6 True False 1342.0553982652348 1365.0818932376096 2539.122157828068 2170.9674818460526 1897.86739841915 1758.9270052053205 1273.3166952099186 1600.20108418509 1786.6943992266065 1432.5655269512488 0.9368195541612429 0.9528931609451359 1.7724300285458956 1.5154402650371275 1.3248032028651042 1.2278160908622633 0.8888366160253488 1.1170177238528132 1.247199074396971 1.0 10.484385415438688 -7.028991222109134 8.317962105150743 1.0705975759435455 1.3152880229250818 0.1732369746222694 0.24394117492452216 0.5551596210497055 144.70568001174817 0.10079841316637629 0.079994979248323 9.354245806090527e-08 7.028991222109134 0.2446904469815363 DTTLIRHS(ph)PQPSPSSSFNEGLLTGGHR ddPTM_A459_Selumetinib_30min_R2 1 DTTLIRHSPQPSPSSSFNEGLLTGGHR 27 1 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4;Q9Y2J4-3 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 DT(0.309)T(0.309)LIRHS(0.36)PQPS(0.019)PS(0.001)SSFNEGLLTGGHR 78.758 4.955300000000001e-05 4725800.0 25784.0 25134.0 25404.0 24174.0 23588.0 17881.0 17117.0 19144.0 14024.0 21303.0 True False 24351.028501530003 27061.696981452238 23769.534297783874 20881.459497524007 20624.664560604462 20343.945442443182 17912.97441669204 19199.7058705402 16829.191863299464 20687.927038158818 1.177064693655126 1.308091281042176 1.1489567927197848 1.0093548502471137 0.9969420581657279 0.9833728340649519 0.8658660862275671 0.928063301611921 0.813478887094781 1.0 14.33650147174606 -5.861228128644921 1.0061706558237764 0.9067094034752259 1.2673636005627695 0.80771663986385 0.06223715660561904 0.24015629198644073 0.47629324914164844 0.02457641416544518 0.06355405203078997 1.3764862305382129e-06 5.861228128644921 0.36065419708754365 DTTS(ph)FEDISPQGVSDDSSTGSR ddPTM_A459_Selumetinib_30min_R2 1 DTTSFEDISPQGVSDDSSTGSR 22 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;A0A2R8Y802 Q3V6T2 CCDC88A Girdin 1 DTT(0.029)S(0.971)FEDISPQGVSDDSSTGSR 291.28 3.099599999999998e-157 0.0 13295.0 8392.7 12503.0 12477.0 18173.0 10298.0 11548.0 12322.0 11464.0 10425.0 True False 12556.11712410182 9036.393103216133 11698.570592237109 10777.611075974468 15889.945271318684 11716.456024063527 12085.004881927895 12357.854979983082 13757.120330923066 10124.003162597086 1.2402324379441254 0.8925711458290426 1.155528144781427 1.0645602241405971 1.5695318359859614 1.1572947811148186 1.1936982523450494 1.2206490635679486 1.358861718035456 1.0 13.305492242788521 DTTS(ph)PMELAALEK ddPTM_A459_Selumetinib_30min_R1 2 DTTSPMELAALEK 13 0 Q6VY07-2;Q6VY07 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 DTT(0.003)S(0.997)PMELAALEK;DTT(0.065)S(0.934)PMELAALEK 253.97 2.6561999999999996e-23 25125000.0 11406.7 13122.400000000001 13252.4 14641.2 14001.0 11834.5 13055.0 12363.0 7604.2 10970.7 True False 11672.453916425511 11586.023307561745 11452.796870222483 12084.389269362597 12734.612022077321 11715.455674866269 12070.250839359202 12035.093079316388 12903.772011206149 12378.896208667362 0.9429317218325799 0.9359496284854163 0.9251872442555541 0.9762089499467198 1.0287356649101635 0.9464055176957886 0.9750668101496759 0.9722266732384223 1.0424008565619352 1.0 13.595595058780455 -5.413623178225924 0.37540131137874777 1.004706829025819 0.896558088478281 0.42142195756402157 0.02837354769349338 4.14020589215299 0.6604196522488954 0.028420980580194162 0.19395682231126585 3.858129685804419e-06 5.413623178225924 -0.10814874054753798 DTTS(ph)PMELAALEK ddPTM_A459_Selumetinib_30min_R2 1 DTTSPMELAALEK 13 0 Q6VY07-2;Q6VY07 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 DT(0.001)T(0.103)S(0.896)PMELAALEK 101.43 0.010121 2715200.0 29107.0 32493.0 24224.0 32249.0 29855.0 21231.0 30547.0 27069.0 22201.0 26578.0 True False 27489.34946455296 34985.10861853772 22665.454213097015 27856.630567372034 26104.34799291361 24155.377534170962 31967.496027732173 27147.766308485818 26641.8203477689 25810.624082062863 1.065040092682483 1.3554538048869063 0.8781443695833923 1.0792699346906163 1.0113799615970878 0.9358695650818372 1.238540219953381 1.0518058851336416 1.0322036485078125 1.0 14.655677404716787 -5.258983983085459 24.983301441167296 1.0356609421990837 1.2102469324104588 0.3005729101575031 0.11051493535804822 257.5669605410108 2620669.455716908 0.027559410277326328 0.06627120658314331 5.508280107378551e-06 5.258983983085459 0.1745859902113751 DTVDPVQDEMLAR ddPTM_A459_Selumetinib_30min_R1 1 DTVDPVQDEMLAR 13 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 144.77 0.032088 0.0 1206.2 1055.7 1251.2 1106.6 1136.5 868.34 1056.7 888.22 502.12 955.19 False True 1234.3021131433666 932.0981532183846 1081.2939123496396 913.3530834546787 1033.7037756653724 859.6052879896384 976.9922682459488 864.6615202548246 852.0609666061958 1077.7979408385038 1.1452073402395868 0.8648171590430319 1.0032436242255354 0.8474251516421617 0.9590886533529401 0.797556995999532 0.9064707133192977 0.8022482577598324 0.7905572411312185 1.0 10.073871020197952 -1.5993308247925928 0.9904919851069399 0.8707199862910515 199.9939109995123 0.4696134280573121 0.07944189227972154 1137.6789772775523 1.927387492954645 0.024168328629363054 513564.9168181494 0.02515759812006379 1.5993308247925928 199.12319101322126 DTYLSHFNPR ddPTM_A459_Selumetinib_30min_R1 1 DTYLSHFNPR 10 0 P40261 P40261 NNMT Nicotinamide N-methyltransferase 0 160.75 0.00061375 9988500.0 4009.5 4418.5 4363.6 5034.7 4720.4 3597.7 3964.6 3792.0 2173.7 3187.6 False True 4102.913548871108 3901.1799658950786 3771.047087539075 4155.484158023923 4293.44065345431 3561.5104044502377 3665.5470300822267 3691.423841848071 3688.6101392334267 3596.7595098533407 1.1407250158458346 1.0846374229936075 1.0484568337716973 1.15534111931586 1.1936968934654675 0.9901997602824049 1.0191248594854458 1.0263193387646288 1.0255370505390924 1.0 11.81248198443538 -6.779226962968719 24.999711558262774 1.0143116820641387 1.119833747042697 0.6832114428011776 0.03816545277970336 166.43782557195615 233919.93243780587 0.014646691746242585 0.012944212619316015 1.662543575453128e-07 6.779226962968719 0.1055220649785582 DTYLSHFNPR ddPTM_A459_Selumetinib_30min_R2 3 DTYLSHFNPR 10 0 P40261 P40261 NNMT Nicotinamide N-methyltransferase 0 ;; 157.75 0.00068418 14706000.0 103505.1 95824.9 120880.5 119863.8 134495.2 99581.9 90356.1 104481.8 94581.0 106601.3 False True 97752.70090574429 103174.36170438297 113103.18023473717 103538.14366341174 117598.71057365654 113298.40281051575 94557.83768721561 104785.8247401068 113499.84281394233 103523.44348555956 0.9442566593080897 0.996627992950937 1.0925368827256396 1.0001419985402074 1.1359621223386018 1.0944226640443977 0.9133954059440211 1.0121941582702794 1.0963685035242705 1.0 16.659597985837713 -3.036278167315654 9.888166197960526 1.030636177087952 0.9846545852394273 0.0 0.06920018871860235 0.0 0.0 0.0162295832497196 0.0 0.0009198602089642064 3.036278167315654 -0.04598159184852468 DVAEVDTVRR ddPTM_A459_Selumetinib_30min_R1 2 DVAEVDTVRR 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 194.12 0.00023181 15140400.0 6680.1 6291.299999999999 10454.7 10922.7 10002.8 7748.3 7777.299999999999 7769.200000000001 4615.1 5611.3 False True 6835.7333327881015 5554.711671253979 9035.009163556411 9015.255489472645 9098.048506137771 7670.359136893509 7190.651999459851 7563.135578081764 7831.487626432434 6331.565013690566 1.0796277568037898 0.8773046883737562 1.426978818668096 1.423858946402542 1.4369351789747582 1.21144758370294 1.1356831974261823 1.1945128197733432 1.2368960295754095 1.0 12.628346428616682 -7.00261579794234 24.97026226985141 1.1602085370569262 1.2555320544351896 0.07465282239731064 0.17261498035583017 374.4477589709507 3574483.280053532 0.06868761039843574 0.05957136816431592 9.93995005139932e-08 7.00261579794234 0.09532351737826339 DVAEVDTVRR ddPTM_A459_Selumetinib_30min_R2 2 DVAEVDTVRR 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 116.52 0.008538200000000001 15258300.0 64891.0 67506.0 77300.0 76174.0 79856.0 51588.0 50132.0 43604.0 39563.0 76833.0 False True 61284.61799925474 72683.49313399826 72326.60215787639 65798.9697925207 69823.77535830204 58693.778730762206 52463.23733467346 43730.880420969224 47476.705482581005 74614.63165389195 0.8213485296493868 0.9741185009281894 0.9693353777228462 0.8818507621633295 0.9357919996467607 0.786625591117566 0.7031226472849168 0.586089878776319 0.6362921645556979 1.0 16.187170944945173 -6.950632696311812 2.806389213152515 0.698139772008723 0.9215110615755476 0.36893259906249665 0.11179036500433086 0.24033484317973336 3.846880088295269 0.042592008459442804 0.03541012659609685 1.1203850462889568e-07 6.950632696311812 0.22337128956682462 DVATSPISPTENNT(ph)TPPDALTR ddPTM_A459_Selumetinib_30min_R2 1 DVATSPISPTENNTTPPDALTR 22 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 DVATSPISPT(0.001)ENNT(0.5)T(0.5)PPDALTR 102.61 0.00013458 3817500.0 17587.0 16847.0 18617.0 21496.0 21264.0 18890.0 17277.0 17759.0 17413.0 19999.0 True False 16609.58494633914 18139.110728357027 17419.202488656978 18568.20771733167 18592.626217428067 21491.926033653137 18080.414733726026 17810.675749839294 20896.086559871183 19421.57690635772 0.8552129946205312 0.9339669387205694 0.8968994934162499 0.9560607672002833 0.9573180544027662 1.106600464899309 0.930944733319123 0.9170561090746915 1.0759212117853714 1.0 14.24537272256311 -5.988876175333918 1.8152746815694665 0.9967728883334693 0.8958293919899704 0.3901915980536471 0.05780277980938477 0.4050662256848234 2.689828785098703 0.01924655867034184 0.03175154485842377 1.025944398569984e-06 5.988876175333918 -0.10094349634349897 DVATSPISPTENNTT(ph)PPDALTR ddPTM_A459_Selumetinib_30min_R2 1 DVATSPISPTENNTTPPDALTR 22 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 DVATSPISPTENNT(0.212)T(0.788)PPDALTR 121.91 4.4154e-05 3888700.0 18495.0 20292.0 20955.0 24738.0 26197.0 18808.0 19368.0 18209.0 18490.0 22741.0 True False 17467.12194135112 21848.331150936134 19606.778114078912 21368.64172456974 22905.898655848538 21398.63127797503 20268.65037696393 18261.985175337762 22188.51665376546 22084.40824178612 0.7909255140602505 0.9893102369660373 0.8878108889954651 0.9675895088797503 1.037197755315357 0.968947460294022 0.9177810043654882 0.8269175689654245 1.0047141137240143 1.0 14.430740555007507 -4.752734808173517 24.99709040033212 0.9502203069166562 0.7909252124673611 0.4058492617095113 0.05945073980016536 367.34536503198296 1054834.1778582667 0.015243577845337869 0.17596493192061186 1.7671165399285997e-05 4.752734808173517 -0.15929509444929502 DVDAS(ph)PSPLSVQDLK ddPTM_A459_Selumetinib_30min_R1 1 DVDASPSPLSVQDLK 15 0 Q8IWZ8 Q8IWZ8 SUGP1 SURP and G-patch domain-containing protein 1 1 DVDAS(0.878)PS(0.122)PLSVQDLK 160.63 0.00012734 6422800.0 1614.9 1772.1 1839.3 1935.8 1606.7 1735.0 1657.1 1782.5 1076.4 1580.9 True False 1652.524027951603 1564.6217081730601 1589.5331625517042 1597.7488694664448 1461.3742686859248 1717.547475253959 1532.103612861136 1735.2223096239954 1826.5721828545156 1783.8239142700315 0.9263941439129331 0.8771166793182765 0.8910818774408941 0.8956875489138559 0.8192368411452438 0.9628458624834649 0.8588872481217389 0.9727542588384209 1.0239643993123488 1.0 10.800757494904975 -7.916783063509587 4.526879325803703 1.0085908434003559 0.8902263136424008 0.6598755890673189 0.036394950416036395 0.11865375099961716 4.38556535387461 0.020460072713526234 0.009226998679055225 1.2112029962053588e-08 7.916783063509587 -0.11836452975795508 DVDAS(ph)PSPLSVQDLK ddPTM_A459_Selumetinib_30min_R2 1 DVDASPSPLSVQDLK 15 0 Q8IWZ8 Q8IWZ8 SUGP1 SURP and G-patch domain-containing protein 1 1 DVDAS(0.724)PS(0.267)PLS(0.009)VQDLK 79.652 0.030676 3064400.0 15666.0 14007.0 16696.0 18287.0 14071.0 12385.0 15273.0 13028.0 12124.0 17872.0 True False 14795.346435966849 15081.291860396326 15621.79753723032 15796.279053165437 12303.275183663956 14090.92133016379 15983.224762875352 13065.909323098504 14549.13877286384 17355.988922967397 0.852463463858748 0.8689387811511601 0.9000810963043311 0.9101341976694871 0.7088777964926491 0.8118766030967615 0.9209054484774735 0.7528184870991835 0.8382777171291451 1.0 14.083145950052447 DVDASPS(ph)PLSVQDLK ddPTM_A459_Selumetinib_30min_R1 2 DVDASPSPLSVQDLK 15 0 Q8IWZ8 Q8IWZ8 SUGP1 SURP and G-patch domain-containing protein 1 1 DVDAS(0.08)PS(0.881)PLS(0.039)VQDLK;DVDAS(0.016)PS(0.841)PLS(0.143)VQDLK 189.52 2.4962e-05 23683000.0 5144.2 6612.0 7153.200000000001 7964.299999999999 6479.7 5841.200000000001 6713.200000000001 5954.299999999999 3732.9 4885.4 True False 5264.049851129258 5837.863966164595 6181.83472971503 6573.484513426805 5893.612279083953 5782.442831385255 6206.81791917167 5796.372621707799 6334.4586597711095 5512.488677825801 0.954931639552223 1.0590251168492426 1.1214235694635892 1.1924712952008232 1.0691382102590499 1.0489713756048797 1.1259556766327403 1.0514983268852656 1.1491105070658403 1.0 12.428488072164654 -4.814196144954163 3.071030960941936 1.098448335592417 0.9380538742952889 0.3857146840052146 0.05289884213030625 0.3336996632369798 4.8601270603548885 0.013256210461343006 0.1268404141492553 1.533924044189738e-05 4.814196144954163 -0.1603944612971282 DVDASPS(ph)PLSVQDLK ddPTM_A459_Selumetinib_30min_R2 2 DVDASPSPLSVQDLK 15 0 Q8IWZ8 Q8IWZ8 SUGP1 SURP and G-patch domain-containing protein 1 1 DVDAS(0.123)PS(0.867)PLS(0.01)VQDLK;DVDAS(0.167)PS(0.767)PLS(0.066)VQDLK 154.81 0.00018095 6760000.0 51697.0 60945.0 63861.0 69008.0 65319.0 48718.0 52253.0 49032.0 45343.0 56745.0 True False 48823.88769948793 65619.2855309385 59752.25278659955 59608.991354560065 57113.043260730985 55428.46228202822 54682.86803735525 49174.67500231545 54412.86698927463 55106.624408783886 0.8859894472452118 1.1907694625635412 1.0843025394434278 1.081702826004681 1.0364097578734524 1.0058402755875033 0.9923102462548751 0.8923550576702918 0.9874106348020354 1.0 15.749938136227028 -6.917109198817621 1.5630554513469823 0.9570828223828876 1.0706923423147094 0.2294245431276848 0.07544733245541577 0.4853392385188354 2.432400398921261 0.03460503336226374 0.027667915985305862 1.2102937795417156e-07 6.917109198817621 0.11360951993182189 DVDDFFEHER ddPTM_A459_Selumetinib_30min_R1 2 DVDDFFEHER 10 0 G3V5X9;Q9UNH7;A0A0A0MRI2;Q9UNH7-2 G3V5X9 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 0 ; 175.33 7.9726e-05 26096000.0 29936.6 32955.0 27342.5 27659.3 30105.3 25333.4 31209.8 29830.1 17684.8 27278.7 False True 30634.064533516583 29096.61327963616 23629.538681601698 22829.122484364736 27382.280930522393 25078.568996886817 28855.61965884588 29038.90884617937 30009.813953312474 30780.186862039256 0.9952527147032079 0.9453033345785362 0.7676866546493795 0.7416823876569623 0.8896073650641981 0.8147633771455702 0.9374738297782423 0.9434286080307271 0.9749717923357746 1.0 14.909714369633996 -7.438920178818696 3.955278703871707 0.9659597647526933 0.8550316359093592 0.336855803763627 0.07282319435478936 0.31232885985940834 9.024809225774312 0.03641114001186754 0.02304719802144407 3.6398192806091386e-08 7.438920178818696 -0.11092812884333414 DVDDFFEHER ddPTM_A459_Selumetinib_30min_R2 4 DVDDFFEHER 10 0 G3V5X9;Q9UNH7;A0A0A0MRI2;Q9UNH7-2 G3V5X9 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 0 ;;; 181.53 0.00013633 40984200.0 190359.0 171354.0 200549.0 207142.0 215498.0 165839.0 172138.0 171710.0 158116.0 169376.0 False True 179779.60884745364 184496.30081004876 187645.8956812411 178928.90226011933 188425.21466343664 188681.81691344653 180142.75808497623 172209.647671879 189743.6181301669 164485.6747883017 1.092980340560573 1.121655737178945 1.1408038780443788 1.0878084215565065 1.1455417920493434 1.1471018199991339 1.0951881269710915 1.046958331742374 1.1535571007893117 1.0 17.32760241820401 -14.522878745279536 0.28768373701167055 0.12098245852136712 1.1207866525157166 0.5217237571467086 0.03260656496948864 194.7246751931534 1.8405666326596755 102.54680162102582 0.035364511704227955 3.0000000000055353e-15 14.522878745279536 0.9998041939943495 DVDDGSGSPHS(ph)PHQLSSK ddPTM_A459_Selumetinib_30min_R1 2 DVDDGSGSPHSPHQLSSK 18 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 DVDDGSGSPHS(0.998)PHQLS(0.001)SK;DVDDGS(0.11)GS(0.352)PHS(0.538)PHQLSSK 105.95 0.0011217 28706000.0 5666.1 5883.0 5898.5 6930.4 8644.900000000001 5909.8 7101.299999999999 6006.200000000001 1455.88 3834.8 True False 5798.109105688635 5194.215625067502 5097.516098141266 5720.135739720141 7862.970321381057 5850.352777669073 6565.643223710573 5846.896065112842 2470.5220267319123 4327.033934115198 1.3399731072075003 1.2004101895562387 1.1780624270014233 1.3219530576410439 1.8171732510318055 1.3520468909531136 1.5173542254766559 1.3512480267406153 0.5709504626838778 1.0 12.079162719585918 -8.239611129184981 17.644472795451556 0.7854807528397525 1.3873915988971761 0.6009788068959483 0.1953231675281754 11.529115278621198 9320.609241705633 0.1386150381606232 0.05197035324612641 5.759554216921475e-09 8.239611129184981 0.6019108460574236 DVDDGSGSPHS(ph)PHQLSSK ddPTM_A459_Selumetinib_30min_R2 2 DVDDGSGSPHSPHQLSSK 18 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 DVDDGSGSPHS(1)PHQLSSK;DVDDGS(0.001)GS(0.004)PHS(0.995)PHQLSSK 107.25 0.0010607 67598000.0 240860.0 172861.0 278830.0 315200.0 338260.0 210210.0 206770.0 214810.0 200061.0 299150.0 True False 227473.9654389742 186118.8828642802 260890.3813671495 272269.21624967206 295764.75471723167 239164.51940361195 216385.21470698225 215435.0615362899 240078.79017138798 290512.7622149565 0.783008511242826 0.6406564773445887 0.8980341496120271 0.93720225636151 1.018078353812178 0.823249614165484 0.7448389291306737 0.7415683217967717 0.8263967074663269 1.0 18.148242016998815 -5.2704514900065345 24.750036023472006 0.8654658058989843 0.7118324917778418 0.312667539953543 0.09536191410966285 683.6838465644518 1877610.5104037006 0.027402609081742586 0.058431113077995325 5.364737913513544e-06 5.2704514900065345 -0.15363331412114245 DVDELPSLQPSVGS(ph)PSRPSSSR ddPTM_A459_Selumetinib_30min_R1 3 DVDELPSLQPSVGSPSRPSSSR 22 1 O43815-2;O43815 O43815-2 STRN Striatin 1 DVDELPSLQPS(0.005)VGS(0.987)PS(0.008)RPSSSR;DVDELPSLQPS(0.084)VGS(0.886)PS(0.029)RPSSSR;DVDELPSLQPS(0.052)VGS(0.427)PS(0.427)RPS(0.024)S(0.024)S(0.046)R 208.99 1.1314e-23 185230000.0 11962.7 14172.8 13811.199999999999 14959.800000000001 13219.400000000001 10771.9 11683.2 11900.8 6578.200000000001 9789.2 True False 12241.407634637835 12513.441987244041 11935.714899491168 12347.351760225298 12023.707604074636 10663.544466102656 10801.926817801712 11585.152124753567 11162.724947281278 11045.739174882772 1.1082470299926988 1.1328750198718 1.080571857665455 1.1178384320627723 1.088538070083684 0.9653989015375992 0.9779270220651713 1.048834481905691 1.0105910315775446 1.0 13.431202345843845 -6.6467186552270725 5.666578913263479 1.0025604409819182 1.1085555747312899 0.828954588672731 0.02397107522849294 0.08970287190891557 4.111972180819554 0.008488113446923086 0.008456466233471351 2.255700027152039e-07 6.6467186552270725 0.10599513374937164 DVDELPSLQPSVGS(ph)PSRPSSSR ddPTM_A459_Selumetinib_30min_R2 4 DVDELPSLQPSVGSPSRPSSSR 22 1 O43815-2;O43815 O43815-2 STRN Striatin 1 DVDELPSLQPS(0.03)VGS(0.906)PS(0.063)RPSSSR;DVDELPSLQPS(0.06)VGS(0.875)PS(0.065)RPSSSR;DVDELPSLQPS(0.029)VGS(0.485)PS(0.485)RPS(0.001)S(0.001)SR;DVDELPSLQPS(0.005)VGS(0.486)PS(0.486)RPS(0.008)S(0.008)S(0.008)R 196.14 1.8896e-22 146786400.0 173105.0 187030.0 195412.0 208899.0 227046.0 174476.0 164664.0 172739.0 154289.0 198323.0 True False 163484.51709421925 201374.59960376413 182839.40466849852 180446.5958291251 198522.45166300653 198508.48526456684 172321.20227552587 173241.64189151907 185151.11119485242 192596.8996849632 0.8488429323713726 1.0455754995701327 0.9493372165781209 0.9369132946806893 1.0307666010602246 1.0306940848439068 0.8947246947245624 0.899503793544423 0.9613400397291437 1.0 17.555224954123226 -10.10050814982675 12.529457254089579 0.9999999989033779 0.9582532251855743 0.043153148879270686 0.061752283985549807 0.0 0.0 0.06003640807576127 0.014560967757591112 7.933993679670384e-11 10.10050814982675 -0.041746773717803554 DVDELPSLQPSVGSPS(ph)RPSSSR ddPTM_A459_Selumetinib_30min_R1 1 DVDELPSLQPSVGSPSRPSSSR 22 1 O43815-2;O43815 O43815-2 STRN Striatin 1 DVDELPSLQPS(0.016)VGS(0.303)PS(0.55)RPS(0.035)S(0.035)S(0.062)R 113.23 2.1196e-05 72907000.0 1698.6 1474.6 1546.7 1810.0 1587.7 1438.0 1709.6 1195.8 784.06 1042.0 True False 1738.1740750997546 1301.9531464770585 1336.666635414952 1493.9174779079783 1444.0928153312018 1423.5350255995334 1580.6434955931443 1164.0834994941786 1330.4925545233286 1175.7508499395096 1.4783523866380202 1.1073376188025223 1.1368621468432034 1.2706071851743401 1.2282302967550462 1.2107454786639293 1.344369426289988 0.9900766812578266 1.131610965530478 1.0 10.199366659769376 -7.769962610721482 24.999673806209447 1.0456328350184187 1.2416652472558096 0.4614617069330078 0.10494372965578243 183.64562809164207 538645.4044255897 0.05470814004951551 0.026948760539322544 1.69838986394011e-08 7.769962610721482 0.19603241223739087 DVDETGITVAS(ph)LER ddPTM_A459_Selumetinib_30min_R1 2 DVDETGITVASLER 14 0 Q8WU90;H7C466 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 DVDETGITVAS(1)LER;DVDETGITVAS(1)LER 225.21 1.1465999999999995e-09 18895800.0 2746.8 3952.5 3919.3999999999996 4007.0 3839.7 3127.9 3878.5 3284.2 1801.2399999999998 2685.9 True False 2810.7950956576037 3489.739462532602 3387.1670077231283 3307.252670705676 3492.399812954093 3096.4361659059705 3585.9416224017345 3197.0923474149367 3056.5727226355125 3030.6614278815077 0.9274526906235135 1.1514778359692917 1.1176329287599853 1.0912643161917004 1.1523556477885255 1.0217030966967633 1.183220794448286 1.0549157084992393 1.008549716083633 1.0 11.565416974263904 -7.999872255792804 24.99970985229206 1.0134274532786038 1.096710438231769 0.1980518825621881 0.06966037971525767 6.441987754373165 1260728.2599339061 0.03664598937540181 0.0173315971521482 1.0002941851711792e-08 7.999872255792804 0.0832829849531651 DVDETGITVAS(ph)LER ddPTM_A459_Selumetinib_30min_R2 2 DVDETGITVASLER 14 0 Q8WU90;H7C466 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 DVDETGITVAS(1)LER;DVDETGITVAS(1)LER 139.21 0.00057249 10202900.0 26660.0 32075.0 34381.0 34444.0 34702.0 29154.0 27187.0 29037.0 22829.3 28333.0 True False 25178.343928435865 34535.04936261957 32168.963891202424 29752.667780785825 30342.42452018384 33169.69886633792 28451.249370018504 29121.49286266586 27395.797903937688 27514.952672025254 0.9150785839451927 1.2551375164723333 1.1691448019065267 1.0813272381542447 1.102761283359695 1.2055153887312302 1.0340286501363019 1.0583878958394135 0.995669454005323 1.0 14.74792822666509 -7.400563435363189 8.429998860166009 1.0254244664400265 1.1269895504517915 0.24030531709597847 0.08635310074283173 0.4440281637928927 28.60116251923517 0.03519072393513388 0.023655685758685485 3.975910179731168e-08 7.400563435363189 0.101565084011765 DVDFEGTDEPIFGK ddPTM_A459_Selumetinib_30min_R2 1 DVDFEGTDEPIFGK 14 0 P42285;H0Y8U3 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 118.48 0.032578 2739000.0 8422.5 6056.7 8811.4 8382.1 7450.2 6008.0 7645.3 7122.6 5816.0 6744.6 False True 7954.4111679388925 6521.229414639996 8244.48411712693 7240.4435200709795 6514.239270366944 6835.547464806143 8000.821598874545 7143.325586790092 6979.362512617629 6549.865873424684 1.21443878724494 0.9956279320312685 1.2587256405628033 1.105433860783048 0.9945607125785139 1.0436164032824822 1.2215244943162797 1.0906063917695326 1.0655733487513963 1.0 12.677249648453197 -8.42324265228967 0.012907790897251113 1.113843545105255e-06 2.1522746643017756 0.14786516984826859 0.0873507022632785 1918.7595904220059 18.078602298899877 1526.888419943332 1483.8255942074386 3.773612898657321e-09 8.42324265228967 2.1522735504582307 DVDIIDHHDNTYTVK ddPTM_A459_Selumetinib_30min_R1 4 DVDIIDHHDNTYTVK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ;;; 107.99 0.0023136 45925100.0 25899.4 27963.5 30886.100000000002 32746.199999999997 30602.1 25311.1 26412.0 24507.6 14842.0 21605.1 False True 26502.80562854031 24689.520420121527 26691.93726520319 27027.690892304017 27834.145458239567 25056.493314640025 24419.721575576816 23857.578836095952 25185.789983209517 24378.325036495313 1.0871462903568874 1.0127652487675156 1.0949044786811362 1.1086771077111532 1.1417579106263762 1.0278184935646508 1.0016980879129116 0.9786389672128917 1.0331222487806442 1.0 14.573311385550479 -6.95599258158196 8.48627431779778 1.0034119902902359 1.086260678208952 0.613145763638747 0.03251537495645354 0.20174720691757128 35.28975180329652 0.01242254633561757 0.010928769800060283 1.1066426869762077e-07 6.95599258158196 0.08284868791871602 DVDIIDHHDNTYTVK ddPTM_A459_Selumetinib_30min_R2 1 DVDIIDHHDNTYTVK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 82.65100000000002 0.035097 5389600.0 20598.0 19818.0 24894.0 19995.0 24717.0 16955.0 17143.0 20365.0 16936.0 23405.0 False True 19453.245620327132 21337.97687508635 23292.34714253785 17271.64650670111 21611.829487216408 19290.397347834245 17940.183468210067 20424.25877839275 20323.673231377597 22729.23683650695 0.85586884241894 0.9387898515278787 1.0247747124147366 0.7598867762669427 0.9508383252227898 0.8487041376088196 0.7892998606708668 0.8985897294003281 0.8941643477767096 1.0 14.47226162416845 -4.4598775776835975 13.401496447865584 0.8935865990310403 0.59253600184546 0.020602189152476802 0.08040298273317062 985804.8854791357 6707365.878025026 0.01975745223670639 7755164.531402287 3.468346051180379e-05 4.4598775776835975 -0.30105059718558036 DVDVS(ph)EDSPPPLPER ddPTM_A459_Selumetinib_30min_R2 1 DVDVSEDSPPPLPER 15 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 DVDVS(0.527)EDS(0.473)PPPLPER 144.88 0.00037156 17979000.0 28329.0 21076.0 26080.0 32050.0 30051.0 19077.0 26783.0 29393.0 26577.0 23955.0 True False 26754.58758997222 22692.46142997881 24402.04119375702 27684.734710666162 26275.724720651393 21704.683586236155 28028.46256950768 29478.528763726892 31893.14262342483 23263.356907435314 1.1500742432155635 0.9754594541222881 1.0489475483204131 1.1900576009224924 1.1294898163322802 0.9329987788348386 1.2048331064614912 1.2671657354104866 1.3709604658660122 1.0 14.505771672588883 -7.497196874540863 22.955725904083128 1.2386377899610166 1.0734528098448384 0.2593262548182854 0.11305279161230192 308.1112500449798 275406.5280234074 0.046416560082161315 0.031115014362623792 3.18275438721195e-08 7.497196874540863 -0.16518498011617821 DVDVSEDS(ph)PPPLPER ddPTM_A459_Selumetinib_30min_R1 4 DVDVSEDSPPPLPER 15 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 DVDVS(0.014)EDS(0.986)PPPLPER;DVDVS(0.49)EDS(0.51)PPPLPER;DVDVSEDS(1)PPPLPER;DVDVS(0.041)EDS(0.959)PPPLPER 220.72 1.9815e-09 101490200.0 6110.299999999999 7584.5 5024.450000000001 5246.82 6672.200000000001 5785.529999999999 7009.47 6352.12 3445.26 6344.29 True False 6252.658101425897 6696.5032140616095 4342.157287328282 4330.561382009468 6068.700688072585 5727.332821040938 6480.74003454333 6183.641143006324 5846.354588165503 7158.64142011779 0.8734420030949133 0.9354433084527124 0.606561641029484 0.6049417938212934 0.847744750982754 0.8000586263401218 0.9053030671896252 0.8638009337398235 0.816684932944903 1.0 12.805470100861859 -6.915372490849626 1.9744943788770128 0.8839445022904204 0.7606101619563557 0.22205691942604622 0.10819340521495487 0.6029246390462722 4.78924471757553 0.05061786867998836 0.04167026631441371 1.2151433349987777e-07 6.915372490849626 -0.12333434033406476 DVDVSEDS(ph)PPPLPER ddPTM_A459_Selumetinib_30min_R2 3 DVDVSEDSPPPLPER 15 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 DVDVS(0.464)EDS(0.536)PPPLPER;DVDVS(0.024)EDS(0.976)PPPLPER;DVDVS(0.01)EDS(0.99)PPPLPER 213.0 6.3239e-07 120143000.0 66603.0 46781.0 57455.0 66343.0 68241.0 52092.0 58795.0 66909.0 50681.0 50856.0 True False 62901.47189293368 50368.95227537663 53758.407852274104 57306.9689519416 59667.955497719515 59267.20015590572 61529.084000082265 67103.69411261869 60818.61614545636 49387.655140243405 1.2736274219603225 1.019869279728845 1.0884988910613251 1.1603500670199902 1.2081552632592842 1.2000407791705825 1.2458393463986397 1.3587139118483762 1.2314538111346467 1.0 15.591862852662459 -6.227788412161555 2.096469237688767 1.230880573718123 1.1174943937915516 0.08430564730210299 0.10291386782057614 0.5498609018204397 4.744867490285784 0.033855458468514746 0.04487040747540809 5.918499126324437e-07 6.227788412161555 -0.1133861799265714 DVEDEETWIR ddPTM_A459_Selumetinib_30min_R1 2 DVEDEETWIR 10 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 ; 199.46 0.00093771 20940500.0 4896.5 4702.9 5890.6 5294.1 4959.3 4862.7 5074.6 4894.0 2840.5 4057.4 False True 5010.5789230695555 4152.282281681107 5090.688874749675 4369.584817564989 4510.73219063553 4813.7856529783385 4691.818836416099 4764.195222047589 4820.121038088302 4578.206812422808 1.0944413671906477 0.9069669527409794 1.1119394739740163 0.9544315048652389 0.9852617794363968 1.0514565746388511 1.0248158348122256 1.0406247286863728 1.0528403882954933 1.0 12.160566920233181 -6.769561179919948 24.998952142008065 1.0359158199055964 1.0073589527828997 0.03669858120561864 0.05818236320384922 606.2424389480683 1866010.0023298168 0.019039395722571132 0.01706405169192382 1.6999604599920354e-07 6.769561179919948 -0.028556867122696783 DVEDEETWIR ddPTM_A459_Selumetinib_30min_R2 2 DVEDEETWIR 10 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 ; 199.46 0.0024127 15297800.0 73283.0 74346.0 71152.0 81145.0 74943.0 59113.0 66054.0 63897.0 50033.0 73531.0 False True 69210.22423509251 80048.09913993187 66574.15778444007 70092.91101706738 65527.99034107945 67255.27917561332 69125.64188351796 64082.92969128223 60040.998038823534 71407.96897351803 0.9692226964298541 1.12099672194315 0.9323071183992 0.9815838767667745 0.917656548464231 0.9418455690926492 0.9680382018588642 0.8974198624112623 0.8408164929195789 1.0 16.123797464406664 -5.2907917383131515 23.90760884764832 0.9337695162699248 1.0451096996635187 0.3955126813796638 0.05445481055742759 336.8545172700374 274368.644512055 0.013884191966120263 0.028910983859535843 5.119272664207882e-06 5.2907917383131515 0.11134018339359397 DVEDEILWVGER ddPTM_A459_Selumetinib_30min_R1 2 DVEDEILWVGER 12 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 ; 212.82 4.7334e-05 8027300.0 1643.0500000000002 1893.17 1819.17 2072.6 2167.2 1636.7 1499.42 1482.12 1044.1 1499.6 False True 1681.3298681812375 1671.5167762891447 1572.1367059855293 1710.6593175204844 1971.1771426502366 1620.2362840046983 1386.317542210032 1442.8093629957455 1771.761441953176 1692.0882673409683 0.9936419397454738 0.98784254258547 0.9291103403583449 1.0109752254288127 1.1649375394274453 0.9575365040210451 0.8192938683917242 0.8526797276734551 1.0470857083226575 1.0 10.724589112891596 -6.995292032097541 24.99641223547737 0.9133348448176587 1.015496241935677 0.1913578763171364 0.08305473718203107 195.79904469878045 1039563.4571231699 0.03040584546137764 0.02671832136086699 1.010899467794268e-07 6.995292032097541 0.1021613971180183 DVEDEILWVGER ddPTM_A459_Selumetinib_30min_R2 1 DVEDEILWVGER 12 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 141.08 0.014144 3397700.0 7959.8 7215.7 7270.4 8344.4 6916.6 6298.7 7954.3 6951.1 5288.7 6589.0 False True 7517.426181604041 7769.120987867626 6802.630379412996 7207.878325107109 6047.674872811468 7166.288751094282 8324.190711146433 6971.32655018345 6346.587778624633 6398.758449722031 1.1748257479434319 1.2141606920956869 1.063117233267105 1.1264495107516095 0.9451325472481595 1.1199498789340288 1.3009071644997077 1.0894811243400337 0.9918467509740636 1.0 12.643576290995215 -7.874316885644772 0.01592138523664555 1.4866886136301127e-06 2.1755138980094464 0.1704911672801266 0.0942894683480867 837.0926467168036 13.542050754190956 921.025822265121 925.5895143648569 1.3356206171058567e-08 7.874316885644772 2.175512411320833 DVEDMELS(ph)DVEDDGSK ddPTM_A459_Selumetinib_30min_R1 3 DVEDMELSDVEDDGSK 16 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 DVEDMELS(1)DVEDDGSK;DVEDMELS(1)DVEDDGSK;DVEDMELS(1)DVEDDGSK 254.68 2.0394999999999991e-78 7579300.0 5776.7300000000005 6767.320000000001 3783.79 3414.2799999999997 4198.9400000000005 4199.91 6279.150000000001 6495.8 3649.04 7557.889999999999 True False 5911.3165694401305 5974.999028358287 3269.9721008707197 2818.040091973288 3819.1466183830707 4157.662718613173 5805.508660127335 6323.510282667913 6192.154364663174 8528.018801582843 0.6931641107947558 0.7006315496454227 0.3834386598988028 0.33044487325124633 0.44783515459349343 0.4875297317404471 0.6807570193266699 0.7414981638518712 0.7260952993576749 1.0 13.05799490344872 -8.183935812985023 0.8593203100246462 0.9731831830492548 0.501244531298789 0.6065959832169605 0.12112788147006716 0.4276015912571198 0.6543701339929545 0.12928642923842557 0.048917871680646346 6.547329338672381e-09 8.183935812985023 -0.4719386517504658 DVEDMELS(ph)DVEDDGSK ddPTM_A459_Selumetinib_30min_R2 5 DVEDMELSDVEDDGSK 16 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 DVEDMELS(1)DVEDDGSK;DVEDMELS(1)DVEDDGSK;DVEDMELS(1)DVEDDGSK;DVEDMELS(1)DVEDDGSK;DVEDMELS(1)DVEDDGSK 268.93 2.1469e-50 21368100.0 212783.0 136912.2 165903.0 184183.0 169195.0 169435.0 237685.0 236104.0 169155.0 140530.0 True False 200957.37269783838 147412.92549789036 155228.98160152903 159096.95766660332 147939.2114775086 192773.13327220862 248737.8234638923 236791.0235508786 202990.72658559782 136472.5337592102 1.4725114802397097 1.0801655207631977 1.1374375291911292 1.1657800532033153 1.084021871672215 1.4125416152405745 1.8226218610607836 1.7350819027707702 1.4874108437361555 1.0 17.058251100332235 -6.961070387775736 5.396099964580274 1.579194365489903 1.181063281892168 0.29024853604554846 0.23127035574374916 0.18675924018345771 13.525043276215337 0.08029778583626362 0.06948318524082527 1.0937790789267942e-07 6.961070387775736 -0.39813108359773497 DVES(ph)PSWR ddPTM_A459_Selumetinib_30min_R1 2 DVESPSWR 8 0 O00159-3;F5H6E2;O00159-2;O00159 O00159-3 MYO1C Unconventional myosin-Ic 1 DVES(0.887)PS(0.113)WR;DVES(0.995)PS(0.005)WR 159.34 0.00047511 32853000.0 6966.0 7302.7 7085.8 7206.7 7891.200000000001 6255.6 6957.3 7082.2 3386.8 5540.5 True False 7128.294246523537 6447.696489066871 6123.587279513329 5948.1851315134945 7177.442353304521 6192.674343630353 6432.505259645635 6894.357049772263 5747.15223791497 6251.677144040173 1.1402211090377656 1.0313546813935468 0.9795111197242561 0.9514543048954468 1.1480826965203883 0.9905620845334171 1.0289247367448988 1.102801198930237 0.9192976709288043 1.0 12.610027559685655 -4.767806611098621 4.853138007383862 1.0199327818218955 1.1478958867809244 0.2504350220084105 0.0641012470370928 0.2544220346733509 14.961784242334392 0.015552038788367318 0.11097693271487705 1.7068422671115643e-05 4.767806611098621 0.12796310495902885 DVESYIHR ddPTM_A459_Selumetinib_30min_R1 2 DVESYIHR 8 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 0 ; 147.19 0.0024515 20244500.0 13754.0 28619.0 14682.099999999999 17052.0 18976.4 19142.9 23599.0 17572.300000000003 7201.5 15816.099999999999 False True 14074.441439374796 25268.274175387847 12688.351463002431 14074.188305683341 17259.987970555543 18950.339806362535 21818.908430336098 17106.22552112523 12220.419523250457 17846.25049686015 0.7886497750242292 1.4158870054991954 0.7109813607757443 0.7886355908855779 0.9671492604898854 1.0618667383211189 1.2226046269032755 0.9585333078303973 0.6847611785680418 1.0 14.123333374935301 -8.019501812119916 24.359984429879635 0.8354694127930224 0.9997493126659535 0.07265113815556312 0.21214585614563597 1437.4547484855532 1795531.2467635367 0.1389372664182138 0.0543007552525837 9.560887056737087e-09 8.019501812119916 0.164279899872931 DVESYIHR ddPTM_A459_Selumetinib_30min_R2 4 DVESYIHR 8 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 0 ;;; 149.65 0.0019605 30107600.0 323350.0 254212.0 343817.0 327238.0 388672.0 302079.0 320904.0 341067.0 345083.0 334343.0 False True 305379.50147260836 273709.2429795863 321696.18853964587 282667.6198829634 339843.54858823394 343687.64024986234 335826.671859213 342059.4485033185 414109.2424246266 324689.6488625608 0.9405273698819813 0.8429872770457361 0.9907805489537425 0.8705778606530661 1.0466719520587109 1.0585112320452916 1.0343005175424191 1.053496622702962 1.2754001979284426 1.0 18.30870186653636 -6.571969351066416 0.8937365569815691 1.109451102903078 0.8975012477220271 0.5031501871454143 0.08012920003385583 0.46940578838136904 0.822320414001911 0.0443706905965476 0.05055684142506654 2.679357405161957e-07 6.571969351066416 -0.21194985518105092 DVGRPQPGR ddPTM_A459_Selumetinib_30min_R1 1 DVGRPQPGR 9 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 110.76 0.030061 15259000.0 2522.4 3282.1 2968.0 2990.0 3366.2 2830.6 3249.4 2919.2 1601.1 2778.3 False True 2581.1670122639925 2897.8302061931045 2564.961902057009 2467.8526292513 3061.727804350881 2802.1267339791657 3004.295141893051 2841.7733331020286 2716.949760282762 3134.9218679337264 0.8233592800720352 0.9243707908111622 0.8181900570771206 0.7872134404669864 0.9766520294073265 0.893842606618483 0.9583317442846595 0.9064893649088243 0.8666722408853985 1.0 11.614213771660944 -6.264448350007517 24.999311836177153 0.9282313830074664 0.8429972543203531 0.46736111885062637 0.04957892191930422 270.0275121877946 2243451.8136117687 0.015116898829884397 0.01789405090749388 5.439408179408734e-07 6.264448350007517 -0.08523412868711333 DVGRPQPGR ddPTM_A459_Selumetinib_30min_R2 1 DVGRPQPGR 9 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 123.21 0.016062 26225000.0 28941.0 25661.0 26757.0 32103.0 25002.0 23213.0 22440.0 20236.0 17809.0 27507.0 False True 27332.575080002323 27629.116186880143 25035.483750818865 27730.516019236085 21861.025239284092 26410.380043366353 23483.504464016438 20294.883409749847 21371.297625035655 26712.801438231 1.0232013719416306 1.0343024579719942 0.937209218161163 1.0380983845276723 0.8183726177066883 0.9886787840068386 0.8791105088067314 0.7597437302365482 0.800039549369365 1.0 14.705243662490213 -6.321018533282179 0.80635181782646 0.8473818819969404 1.0267258988197028 0.35197532101099327 0.08071227340302435 0.691389704433824 0.9783071975247203 0.04483983421571338 0.07104584971927672 4.775088957889625e-07 6.321018533282179 0.17934401682276235 DVKPHNVMIDHEHR ddPTM_A459_Selumetinib_30min_R1 1 DVKPHNVMIDHEHR 14 1 P68400;E7EU96;A0A2R8YD58;A0A2R8YFU2;A0A2R8Y5A0;A0A2R8YDP2;Q8NEV1;A0A2R8Y4H0;A0A2R8Y4D6;P68400-2;V9GYW6 P68400;P68400-2 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 90.861 0.0069557 6074700.0 1699.9 1928.5 1803.1 2082.4 1913.9 1488.1 1821.8 1741.9 1198.4 1461.7 False True 1739.5043625703947 1702.7103234646731 1558.2489237193377 1718.747931489269 1740.7880829264889 1473.1310650866947 1684.380159260405 1695.6991535113825 2033.5972723270631 1649.323433163706 1.054677528732921 1.0323689636777675 0.9447806854537495 1.0420927132481188 1.0554558602173842 0.8931729431994778 1.0212552161642752 1.0281180267103338 1.232988770690203 1.0 10.687658624411746 -8.02538781798995 24.053474173940987 1.1211807882979485 1.0053091344023377 0.2710655230654184 0.07121481792034062 555.7191377221992 526506.2332819614 0.04521508318898621 0.01726878393567167 9.43218221396213e-09 8.02538781798995 -0.11587165389561083 DVLLQVDDERR ddPTM_A459_Selumetinib_30min_R1 2 DVLLQVDDERR 11 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ; 250.7 2.3771999999999997e-15 36893000.0 12311.5 12856.2 13023.6 14069.0 13666.9 12062.599999999999 12144.9 11881.0 6582.2 9828.3 False True 12598.333995991174 11350.990127314773 11255.066653514046 11612.113257838311 12430.731308087168 11941.261195964486 11228.800415084914 11565.877285073031 11169.512655132845 11089.858040749023 1.1360230175805088 1.023546927797113 1.0148972702948924 1.0470930480056906 1.1209098675935423 1.076773133802708 1.0125287784411086 1.0429238356861652 1.007182654105322 1.0 13.436953277491073 -7.264029982021398 24.93385541448827 1.0192358014505252 1.0665534963813645 0.33286529874494597 0.03728687726186735 344.6295552493925 3316921.67740608 0.015973165221401506 0.011322082113146758 5.444650637701108e-08 7.264029982021398 0.04731769493083937 DVLLQVDDERR ddPTM_A459_Selumetinib_30min_R2 4 DVLLQVDDERR 11 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;;; 236.22 3.7666e-10 29831500.0 134724.0 127159.0 148059.0 148685.0 144533.0 121002.0 116520.0 125292.0 113335.0 132715.0 False True 127236.5794229028 136911.6864193716 138533.04513445037 128433.84650406835 126375.47239858586 137668.92715320774 121938.41087999968 125656.57897679285 136005.16684448422 128883.17311501876 0.9872241375478357 1.0622929519060489 1.0748730170603404 0.9965136906541755 0.9805428384805908 1.0681683560843769 0.9461158344633447 0.9749649697455353 1.0552592984586873 1.0 16.97570439330954 -5.787032536923117 24.994924880939116 1.0014369443523652 1.0435463398419182 0.15996423209989385 0.04009859588374826 365.24445275137293 356706.0005935865 0.011292850611788845 0.016755792922622432 1.6329296058026304e-06 5.787032536923117 0.04210939548955306 DVLS(ph)VAFSSDNR ddPTM_A459_Selumetinib_30min_R1 2 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6R9L0;D6R9Z1;D6RFZ9;D6RHH4;D6RFX4;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 DVLS(1)VAFSSDNR;DVLS(0.995)VAFS(0.003)S(0.002)DNR 110.92 0.007338 0.0 2044.13 2843.02 2866.23 2893.7 2830.0 2487.9700000000003 2653.39 2447.3599999999997 1649.57 2201.8599999999997 True False 2091.754251815412 2510.1578967158607 2477.011709074417 2388.369616476419 2574.02699967708 2462.943280696019 2453.2426560434565 2382.448062654352 2799.1998101740273 2484.4901789326373 0.8419249428122316 1.010331181020909 0.9969899378465512 0.961311755920278 1.0360383073773745 0.991327436743632 0.9874229638119942 0.9589283478986728 1.1266697022632597 1.0 11.27873412365891 -4.760154318748888 24.91811872293042 1.0043461858661409 0.8419247384646219 0.546345186353591 0.04521823150595198 23.414928453706104 453844.1389797769 0.01066276312119957 0.06448477278735681 1.7371834421122123e-05 4.760154318748888 -0.16242144740151898 DVLS(ph)VAFSSDNR ddPTM_A459_Selumetinib_30min_R2 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6R9L0;D6R9Z1;D6RFZ9;D6RHH4;D6RFX4;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 DVLS(0.997)VAFS(0.001)S(0.001)DNR 93.494 0.020222 1224900.0 4126.4 3616.9 4571.1 4263.1 4283.3 2706.8 4272.5 5137.6 2973.1 5075.8 True False 3897.071207287987 3894.3045998334737 4277.000402637374 3682.458425742306 3745.1935608121535 3079.6371301160543 4471.17971579814 5152.549565424532 3567.8030753547932 4929.248465487798 0.790601495252955 0.7900402317106759 0.8676779903838996 0.747062853805218 0.7597899734684057 0.6247680861855872 0.9070712801562281 1.0453012465287923 0.7238026446292607 1.0 12.267151988514119 -7.486170656418499 23.59865369409922 0.9259684154102229 0.7681762829893779 0.3861417691547194 0.09620578420215922 302.33957684972705 194366.53542499404 0.03938162165097805 0.026538186153894663 3.2645952439248686e-08 7.486170656418499 -0.157792132420845 DVLSLLNLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 DVLSLLNLSPR 11 0 Q96AY4;A0A087WW06 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 DVLSLLNLS(1)PR 116.98 0.0057309 1795900.0 411.35 300.83 499.34 538.15 330.78 445.77 544.27 381.68 245.95 229.86 True False 420.93365465223343 265.6086837479273 431.53237067828405 444.1722048266182 300.8610074039521 441.285958526776 503.215275705709 371.5566065286321 417.3591865227316 259.36477002600344 1.6229407510126814 1.0240738698679002 1.66380488234782 1.712538695143856 1.1599918037202521 1.7014105596628775 1.9401836095752618 1.4325639002219943 1.6091591255084023 1.0 8.01883871886118 -10.772141425381127 5.71260483335961 0.9999724100712376 1.5363108503448015 0.28331341929099774 0.2579263248892175 9.178769993855394e-05 1.2062535625486168e-05 0.2529198286222838 0.06133892156947554 1.6898905393607014e-11 10.772141425381127 0.5363384402735639 DVMEDAVEDRLDR ddPTM_A459_Selumetinib_30min_R1 1 DVMEDAVEDRLDR 13 1 R4GMY7;M0R1A1;Q15833-2;Q15833;Q15833-3 R4GMY7 STXBP2 Syntaxin-binding protein 2 0 105.25 0.020752 2095100.0 450.94 492.31 364.55 630.45 642.58 499.31 554.63 581.21 289.27 477.92 False True 461.44602462350355 434.6701163312903 315.04611232981244 520.3537425122016 584.4587524567132 494.28739473720697 512.7938125648254 565.7944227638496 490.87006255511477 539.26568733502 0.8556932796965241 0.8060407449236624 0.5842131619512617 0.9649301906889743 1.0838048223409715 0.916593446135819 0.9509112569334515 1.0491941839651087 0.910256435896988 1.0 9.074852430026935 -5.8851073023179135 9.001582349140707 0.9861412742853646 0.7549321626473572 0.6296680654436322 0.08215743928252629 0.1687398611661622 12.593054081799425 0.02302555597285798 0.03422648198477912 1.3028448412673536e-06 5.8851073023179135 -0.2312091116380074 DVMQET(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 DVMQETFK 8 0 Q3KP31;C9JU55;M0QYR3;C9JIP4;P17024 Q3KP31 ZNF791;ZNF20 Zinc finger protein 791;Zinc finger protein 20 1 DVMQET(1)FK 95.502 0.041228 0.0 584.38 889.54 736.11 750.43 749.62 682.06 843.44 677.36 349.97 677.0 True False 597.9949169944624 785.3922432640736 636.1503051627986 619.3814878157369 681.8170033561602 675.1990956609302 779.8186417425603 659.3942124246332 593.8735292025221 763.899544538434 0.7828187898132404 1.028135504045399 0.832766964859464 0.8108153647217864 0.8925479904142762 0.8838846684597793 1.0208392547396332 0.8631949281015144 0.7774235937807168 1.0 9.577239121065865 -6.805650556468508 3.5423016126822184 0.908827876084591 0.8722493181732422 0.05141950786593119 0.08860496152768904 1.0428627782973623 26.963538332215517 0.03267553406149981 0.02964701887140387 1.564405894057184e-07 6.805650556468508 -0.036578557911348786 DVMS(ph)DETNNEETESPSQEFVNITK ddPTM_A459_Selumetinib_30min_R1 1 DVMSDETNNEETESPSQEFVNITK 24 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DVMS(1)DETNNEETESPSQEFVNITK 164.99 3.4106999999999997e-14 13013000.0 1737.9 1954.1 2203.7 1925.0 1992.9 1309.1 1497.3 1680.8 920.94 1336.3 True False 1778.3896886352666 1725.3130635635555 1904.449644057627 1588.8348867253358 1812.6425468750735 1295.9316425676986 1384.3574555168534 1636.219723992153 1562.7679172036765 1507.8271216642684 1.1794387188581434 1.1442379824414064 1.263042438151388 1.0537248361547276 1.2021554200950864 0.8594696460541912 0.9181141761058556 1.0851507447260738 1.036437065463292 1.0 10.558255312065048 -6.74398530211238 24.99989399463202 0.9812987214163217 1.1660446703390965 0.609521983199475 0.0754937851421663 178.7577498515112 256038.5186398937 0.025948800276813747 0.02589100788426093 1.8030787616684268e-07 6.74398530211238 0.18474594892277485 DVMSDETNNEETES(ph)PSQEFVNITK ddPTM_A459_Selumetinib_30min_R1 7 DVMSDETNNEETESPSQEFVNITK 24 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DVMSDETNNEETES(0.993)PS(0.006)QEFVNITK;DVMSDETNNEET(0.001)ES(0.999)PSQEFVNITK;DVMS(0.001)DET(0.002)NNEET(0.034)ES(0.747)PS(0.215)QEFVNIT(0.001)K;DVMSDETNNEET(0.002)ES(0.908)PS(0.091)QEFVNITK;DVMSDETNNEET(0.004)ES(0.993)PS(0.002)QEFVNITK;DVMSDETNNEETES(0.998)PS(0.002)QEFVNITK;DVMSDETNNEET(0.008)ES(0.99)PS(0.002)QEFVNITK 194.11 4.303699999999999e-27 202777300.0 27002.7 31452.699999999997 32375.800000000003 33933.9 30781.9 27427.0 29511.600000000002 26854.9 16567.56 22501.359999999997 True False 27631.810371892207 27770.203262036463 27979.34418753956 28007.981383194227 27997.68257998583 27151.10928172353 27285.516252074547 26142.620814990976 28113.939273293538 25389.628737807012 1.0883109263723272 1.0937616909964738 1.1019989491172146 1.1031268583099956 1.1027212279908305 1.0693779559404721 1.074671730486725 1.0296574670295475 1.1073001328069767 1.0 14.631951678747521 -13.271048396788837 0.15161749927980442 0.791890438218642 1.1146663873563651 0.6177347351170251 0.020993978754406048 55.32848564884172 0.7030311700222966 3.65017579374889 0.10770859063891236 5.357369528797565e-14 13.271048396788837 0.3227759491377231 DVMSDETNNEETES(ph)PSQEFVNITK ddPTM_A459_Selumetinib_30min_R2 3 DVMSDETNNEETESPSQEFVNITK 24 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DVMSDET(0.001)NNEET(0.052)ES(0.947)PSQEFVNITK;DVMSDETNNEETES(0.692)PS(0.308)QEFVNITK;DVMSDETNNEET(0.008)ES(0.97)PS(0.022)QEFVNITK 151.75 1.4112e-09 17202300.0 104575.0 94888.0 101705.0 120531.0 119963.0 95899.0 96613.0 100900.0 80606.0 109459.0 True False 98763.14014689342 102165.6044869915 95161.41102803113 104114.46987242777 104892.17545717277 109108.2167655532 101105.69593502775 101193.60229510587 96729.45231981705 106298.63426136375 0.9291101511620338 0.9611186935458635 0.8952270336235104 0.9794525639570718 0.9867687970408647 1.0264310310636855 0.9511476477339513 0.9519746231761944 0.9099783171435835 1.0 16.69776353549195 -5.793247785600501 24.999558112753558 0.9722325573881999 0.9317485804791649 0.267876982312491 0.03302404674279659 286.75930184582893 225374.8718904814 0.009803134386991577 0.014541650942534973 1.609726947552876e-06 5.793247785600501 -0.04048397690903505 DVMSDETNNEETESPS(ph)QEFVNITK ddPTM_A459_Selumetinib_30min_R2 1 DVMSDETNNEETESPSQEFVNITK 24 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DVMSDETNNEET(0.013)ES(0.488)PS(0.498)QEFVNITK 108.64 3.0529e-07 7010300.0 16208.0 16543.0 18471.0 20126.0 20004.0 16141.0 15931.0 14671.0 13810.0 19732.0 True False 15307.224245764743 17811.79490587111 17282.595969704205 17384.804080713497 17490.918681970998 18364.27623659053 16671.823066677633 14713.690181085205 16572.385883639872 19162.285890107014 0.7988203669201837 0.9295234925529877 0.901906801141442 0.90724061734664 0.9127782970298497 0.9583551952990913 0.8700331036854458 0.7678462927370006 0.8648438906861191 1.0 14.225982051563625 -9.670269948008745 9.378755750468397 0.9999999865618544 0.8818155285878111 0.3008082195212388 0.055178984602074176 0.0 0.0 0.05694473081442665 0.0138111258806027 2.1366335916704018e-10 9.670269948008745 -0.11818445797404331 DVNAAIAT(ph)IK ddPTM_A459_Selumetinib_30min_R1 2 DVNAAIATIK 10 0 Q9BQE3;F5H5D3;A0A1W2PQM2;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 DVNAAIAT(1)IK;DVNAAIAT(1)IK 112.44 0.019267 22861000.0 13982.4 12949.3 14216.0 15017.199999999999 12079.8 11549.5 10671.6 13070.8 8835.900000000001 10376.4 True False 14308.162714985749 11433.18993603376 12285.545282898403 12394.727927756745 10987.184222861906 11433.322516106966 9866.632620245553 12724.119924057955 14993.876951397455 11708.312014695133 1.2220517096766412 0.9765019860833852 1.0493011518209272 1.0586263769021607 0.9384089020750269 0.9765133096689748 0.8427032528567667 1.0867595523665476 1.2806181567913975 1.0 13.515245477287413 -10.886646012969903 3.0952222966505323 0.9996171610827242 1.0359784614872463 0.005118140104290347 0.12316235505500368 91747305.84439902 115822875.25468628 317665.47246311937 0.03139492002005634 1.2982370137022029e-11 10.886646012969903 0.03636130040452201 DVNAAIAT(ph)IK ddPTM_A459_Selumetinib_30min_R2 2 DVNAAIATIK 10 0 Q9BQE3;F5H5D3;A0A1W2PQM2;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 DVNAAIAT(1)IK;DVNAAIAT(1)IK 109.0 0.024178 11079200.0 115346.0 87674.0 107190.0 97790.0 81897.0 68825.0 89494.0 91181.0 77259.0 80035.0 True False 108935.53108662282 94398.31388365745 100293.51209964766 84470.8333028407 71608.36669153067 78305.0190188554 93655.64832899676 91446.32161417282 92712.95879682338 77724.18159409668 1.4015654954789092 1.2145295318339795 1.2903772036277725 1.0868024798765645 0.9213138719876786 1.0074730593857142 1.204974390313942 1.1765491734829456 1.192845738550242 1.0 16.246075900168805 -5.759840052096575 8.77381805941717 1.0865446300285206 1.293750705532367 0.518435992747627 0.09611162671696716 0.10006458014153065 83.5448842556616 0.029240522005595772 0.04710833044561265 1.7384409676459272e-06 5.759840052096575 0.2072060755038463 DVNAAIATIK ddPTM_A459_Selumetinib_30min_R1 2 DVNAAIATIK 10 0 Q9BQE3;F5H5D3;A0A1W2PQM2;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 ; 149.96 0.010089 40542000.0 3250.8999999999996 3165.2 3629.5 3586.8 3264.5 2722.7 2650.3 2567.7 2357.1 2885.7 False True 3326.6396448497535 2794.6169125384413 3136.6338354164145 2960.4327125747727 2969.2265513942875 2695.3121100138037 2450.38573723123 2499.596254934942 3999.8265442274023 3256.1077040983155 1.0216614274345601 0.85826918717123 0.9633077651173748 0.9091937311682319 0.9118944522802659 0.8277711780299332 0.7525505787621952 0.7676638741982684 1.228407321782692 1.0 11.668932705887448 -11.397970268624228 6.188250496293942 1.0163072615910531 0.9033179210165222 0.028426339322871974 0.13124963928943698 0.0321844519174983 0.0006496355490959955 0.13851000073698866 0.03027928937390524 3.999721305249986e-12 11.397970268624228 -0.11298934057453092 DVNAAIATIK ddPTM_A459_Selumetinib_30min_R2 2 DVNAAIATIK 10 0 Q9BQE3;F5H5D3;A0A1W2PQM2;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 ; 160.36 0.0061422 25409000.0 176822.0 153773.0 188231.0 183664.0 180105.0 145429.0 152247.0 141130.0 112918.0 152243.0 False True 166994.9411145494 165566.8946418734 176120.42239041708 158648.64636192762 157478.59974087094 165460.52467697946 159326.7871717073 141540.66493467073 135504.75519253046 147847.3490151815 1.129509201395297 1.1198502762797078 1.1912315206431763 1.0730570917821258 1.0651432087882784 1.1191308182332669 1.0776438551857095 0.9573432724866566 0.9165179903132138 1.0 17.17374884980618 -7.693997171812717 3.3205268856496657 0.9494486059049977 1.1147558946569092 0.7812875412039172 0.037448766686958776 0.11159042942715185 2.4580520908877075 0.021774747619927794 0.01098359136177658 2.0230323529090796e-08 7.693997171812717 0.16530728875191147 DVNSSS(ph)PVMLAFK ddPTM_A459_Selumetinib_30min_R2 3 DVNSSSPVMLAFK 13 0 C4P0D4;Q5VVQ1;C4P0D6;C4P0D8;Q99598;Q9NRI2 C4P0D4 DISC1;TSNAX;TRAX Translin-associated protein X 1 DVNS(0.019)S(0.07)S(0.911)PVMLAFK;DVNS(0.001)S(0.204)S(0.794)PVMLAFK;DVNS(0.011)S(0.126)S(0.863)PVMLAFK 253.06 3.6337e-23 27796200.0 158372.0 135684.0 154908.0 162224.0 174794.0 129052.0 147281.0 144485.0 129388.0 137094.0 True False 149570.3182533476 146090.5265071759 144941.38793107786 140128.81134799088 152834.81504181353 146827.74158258346 154129.85833176476 144905.4274292207 155269.21540278025 133135.7400070104 1.1234422721162012 1.097305100039128 1.0886737695185817 1.0525258757761984 1.1479623355363922 1.102842419134427 1.1576895754937697 1.0884036654739782 1.1662474358470865 1.0 17.022538386102923 -4.746529355568404 23.147039698533458 1.10447025656584 1.1234424026467724 0.01395580858644807 0.047659399877829314 2059.0838111833273 3196135.131400826 0.01112313739616492 0.22581415424185025 1.792547383370768e-05 4.746529355568404 0.01897214608093245 DVPDGPLLREETY(ph)DVPPAFAK ddPTM_A459_Selumetinib_30min_R1 1 DVPDGPLLREETYDVPPAFAK 21 1 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4;H3BN62 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 DVPDGPLLREET(0.22)Y(0.78)DVPPAFAK 73.138 0.037000000000000005 3739300.0 1007.4 1449.6 1953.3 2055.1 1390.9 1550.2 1155.5 961.16 729.3 765.46 True False 1030.870459940829 1279.8801580992433 1688.052588708881 1696.2153640047986 1265.0933405833398 1534.6063954689832 1068.3397047016135 935.6669145123133 1237.5688340354866 863.7142472118018 1.1935318460574575 1.4818328657086381 1.9544109572791768 1.9638617395515177 1.4647128314338331 1.7767524391578826 1.2369133751705188 1.0833061021429082 1.4328452240200311 1.0 9.754410277257929 -7.318610755611651 6.592375028746397 1.1913148351000962 1.6529196296350688 0.45367952540584666 0.24224514362259605 0.24075747566198336 22.567847036642533 0.10743423544933942 0.07233170569721285 4.8016361127347146e-08 7.318610755611651 0.4616047945349726 DVPGGGPSSSAPAGAEADGPKAS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 2 DVPGGGPSSSAPAGAEADGPKASPEAR 27 1 Q8N3F8;B0QY86 Q8N3F8 MICALL1 MICAL-like protein 1 1 DVPGGGPSSSAPAGAEADGPKAS(0.999)PEAR;DVPGGGPSSSAPAGAEADGPKAS(1)PEAR 99.13 8.569499999999998e-07 12376900.0 35080.0 23543.0 29319.0 35190.0 30816.0 29499.0 40610.0 35634.0 33625.0 26101.3 True False 33130.39403636646 25348.672397323553 27432.647460113578 30397.061293864048 26944.618581464598 33562.219484739755 42498.445467188416 35737.68904047373 40350.93956099862 25347.687649678202 1.307038120961975 1.000038849604704 1.0822544383239567 1.1992045078814102 1.063001049794247 1.324074209395027 1.6766202130365904 1.4098993775839521 1.5918982480246433 1.0 14.629566522497909 -6.948162325046167 4.999971205891272 1.4602910156847937 1.126659667891219 0.3495518022196443 0.18417669866765404 0.18350159850929573 9.898966245487744 0.062431476590742024 0.054155298841082916 1.1267762254289644e-07 6.948162325046167 -0.3336313477935746 DVPPDILLDS(ph)PER ddPTM_A459_Selumetinib_30min_R1 4 DVPPDILLDSPER 13 0 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 DVPPDILLDS(1)PER;DVPPDILLDS(1)PER;DVPPDILLDS(1)PER;DVPPDILLDS(1)PER 199.33 0.00013464 18007500.0 6156.09 7976.2300000000005 7695.97 9252.69 7348.63 6193.65 6639.85 6500.89 3485.98 5931.47 True False 6299.514919334062 7042.369283551275 6650.899544937224 7636.881386002416 6683.947714006 6131.347504384249 6139.000768726095 6328.465279333256 5915.453454094374 6692.831951910465 0.9412330930460414 1.052225624989887 0.9937347288450487 1.1410538081450665 0.9986725741855913 0.9161065970936353 0.9172500987379073 0.945558670052488 0.8838490935673069 1.0 12.70840107527053 -6.624720037963917 4.809905292194371 0.9287541330159511 1.0350121714354177 0.42577094423231465 0.05466288722253299 0.19072976682016973 7.372386957079746 0.01791603501877877 0.01788479750700574 2.372902872321447e-07 6.624720037963917 0.10625803841946657 DVPPDILLDS(ph)PER ddPTM_A459_Selumetinib_30min_R2 3 DVPPDILLDSPER 13 0 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 DVPPDILLDS(1)PER;DVPPDILLDS(1)PER;DVPPDILLDS(1)PER 148.7 0.00049872 3513800.0 21023.7 21167.0 18861.199999999997 23936.5 23674.0 16600.2 17876.9 19275.5 17290.899999999998 19012.6 True False 19855.28691853927 22790.440837367685 17647.690926521846 20676.307407234355 20699.860471754713 18886.726868387963 18708.21127240532 19331.588513769195 20749.56314811214 18463.6568373327 1.075371314223776 1.2343405771757208 0.9558069174487144 1.1198381549979728 1.12111379961853 1.022913664112292 1.0132451787436896 1.0470075719064262 1.1238057190359734 1.0 14.172400695187996 -6.761334173375053 24.999999998156436 1.0425730692954198 1.1016332213137807 0.1521191981680513 0.07067860378487813 5.889744093312442 1399465.3874382586 0.02389323640208063 0.022492799807067913 1.7324704135042977e-07 6.761334173375053 0.0590601520183609 DVPPDILLDS(ph)PERK ddPTM_A459_Selumetinib_30min_R1 4 DVPPDILLDSPERK 14 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK 138.28 0.0010417 61951300.0 9929.99 11789.02 13201.98 14413.61 11276.77 11683.66 11130.609999999999 10436.93 6307.8 8964.12 True False 10161.339446602966 10408.756057833296 11409.22362928525 11896.54359046919 10256.788144575452 11566.132988314497 10291.019126394473 10160.10871247347 10703.875896515903 10114.752119922996 1.004605879227451 1.029066845576097 1.1279785697182374 1.1761577001018744 1.0140424622342141 1.1434914915544714 1.0174267252802256 1.0044842020855 1.0582440152371615 1.0 13.304173344058617 -7.314358726240167 24.948380902581015 1.0204123605666529 1.0833306925472725 0.23642180011961433 0.05503012762275397 521.8668698008145 246027.82862472566 0.02385111168971075 0.016080427025430055 4.848878184843635e-08 7.314358726240167 0.06291833198061969 DVPPDILLDS(ph)PERK ddPTM_A459_Selumetinib_30min_R2 7 DVPPDILLDSPERK 14 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK;DVPPDILLDS(1)PERK 106.19 0.007352199999999999 22867500.0 106856.0 98622.8 111846.6 107503.0 105368.3 81187.7 94162.6 92776.0 68522.70000000001 95241.4 True False 100917.37129845984 106186.85163771654 104650.51152537057 92860.90594698116 92130.99214944629 92370.56872643835 98541.34747965212 93045.9628001065 82229.1546842064 92491.53331512478 1.091098478761593 1.1480710485783698 1.131460445885564 1.0039935831812616 0.9961019008685899 0.9986921550075908 1.065409383407184 1.0059943809461211 0.8890452102685575 1.0 16.49703368676392 -5.7723880652595385 7.962828734359277 0.9974779719888487 1.1262006622389147 0.6578797951334845 0.04269556043894907 0.08484565316102771 34.351324795889965 0.012264906304028692 0.019160544547730574 1.688931107255963e-06 5.7723880652595385 0.128722690250066 DVPSPGGLSAPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 DVPSPGGLSAPSSPR 15 0 E9PIR9;E7ET48;Q8N1P7 E9PIR9 AIM1L Absent in melanoma 1-like protein 1 DVPSPGGLS(0.001)APS(0.612)S(0.387)PR;DVPSPGGLS(0.001)APS(0.831)S(0.169)PR 152.11 0.00039688 0.0 68674.0 61572.0 62832.0 63694.0 70104.0 49569.0 60419.0 65227.0 55207.0 72477.0 True False 64857.374003803634 66294.37441481568 58789.45752630907 55018.76732172141 61296.90878228821 56396.67980741938 63228.603217977274 65416.79977108888 66249.94261246234 70384.40069213908 0.9214736982344905 0.9418901597924638 0.8352626000675033 0.7816897889402106 0.8708876992559828 0.8012667473592351 0.8983326219475645 0.9294218481339572 0.9412588863580605 1.0 16.10296809906818 -8.059079667334716 1.3361301920920652 0.9873870910256958 0.8589350515990524 0.47673822799418053 0.047409149466987106 0.41581122948368354 1.343330651013318 0.047555099232323844 0.015798489261787046 8.728112444938794e-09 8.059079667334716 -0.1284520394266434 DVPYPPPLS(ph)PAIEAIQK ddPTM_A459_Selumetinib_30min_R2 2 DVPYPPPLSPAIEAIQK 17 0 G3V2R9;G3V3Y1;Q8N8N7 G3V2R9 PTGR2 Prostaglandin reductase 2 1 DVPY(0.003)PPPLS(0.997)PAIEAIQK;DVPYPPPLS(1)PAIEAIQK 119.68 0.0013992000000000002 0.0 11471.7 9337.9 12039.5 14589.8 13213.8 8549.0 8951.3 10270.1 6850.3 9608.7 True False 10834.14883885362 10054.0869039191 11264.891677616462 12602.64407119118 11553.764311129184 9726.547149904749 9367.553186664456 10299.984290693425 8220.551413374233 9331.271864599203 1.16105810612549 1.0774615775650154 1.2072193202679036 1.3505815985281542 1.238176797201851 1.0423602796104499 1.0038881432876152 1.1038135465508516 0.8809679465626975 1.0 13.187858020368678 -6.837065316208032 5.103635479263469 1.0088220886645909 1.207550010374554 0.6044978689030174 0.0814493487396351 0.16329645862624312 7.635360992210745 0.03137514576283017 0.027877475336219152 1.4552402016330043e-07 6.837065316208032 0.19872792170996312 DVS(ph)LGTYGSR ddPTM_A459_Selumetinib_30min_R2 1 DVSLGTYGSR 10 0 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DVS(0.984)LGT(0.016)YGSR 104.07 0.010958 0.0 12555.0 12367.0 14477.0 17015.0 19170.0 10816.0 11006.0 12142.0 10066.0 13297.0 True False 11857.243361647119 13315.509133827469 13545.565581365814 14697.527647487834 16761.69321802559 12305.805822127693 11517.800807975265 12177.33120978369 12079.481267539391 12913.081060244946 0.9182350289855767 1.031164372910309 1.0489801402291261 1.1381890641681638 1.2980398047394928 0.9529720881264465 0.8919483084044689 0.9430229046786995 0.9354453217774704 1.0 13.656545648203997 -6.96423965250208 24.999910864671577 0.9356562839977909 1.088658598451338 0.3689116670865362 0.09291002538093326 195.44715219416747 136635.7551524827 0.03504056846860907 0.030902784688958313 1.0858262773074911e-07 6.96423965250208 0.15300231445354706 DVSGFSDPYCLLGIEQGVGVPGGS(ph)PGSR ddPTM_A459_Selumetinib_30min_R1 1 DVSGFSDPYCLLGIEQGVGVPGGSPGSR 28 0 K7EIH3;K7EQ37;K7EN81;Q70J99-2;Q70J99;Q70J99-3 K7EIH3 UNC13D Protein unc-13 homolog D 1 DVSGFSDPYCLLGIEQGVGVPGGS(0.587)PGS(0.413)R 145.01 4.3876999999999996e-14 8040000.0 2284.8 2696.3 2934.0 3217.4 3183.9 2693.5 2535.5 2633.3 1553.0 1898.6 True False 2338.0313945531125 2380.615942524138 2535.578915308378 2655.541488077973 2895.916807163202 2666.4058355023267 2344.2451936572384 2563.4563298361113 2635.3275733677656 2142.3038039300905 1.0913631345208632 1.1112410565470967 1.1835757891372913 1.2395727829107803 1.3517769057080498 1.2446441212543071 1.0942636564229047 1.1965886094835896 1.230137186207304 1.0 11.064947370419759 -10.646790388084593 13.901274947787767 0.9999999999998669 1.1956221367070758 0.3664215107436384 0.07636760511183321 0.0 0.0 0.08187511530587549 0.01985763241358324 2.2553274816715988e-11 10.646790388084593 0.19562213670720896 DVSHS(ph)SPVDLK ddPTM_A459_Selumetinib_30min_R2 1 DVSHSSPVDLK 11 0 Q96JN0-2;Q96JN0 Q96JN0-2 LCOR Ligand-dependent corepressor 1 DVS(0.001)HS(0.849)S(0.15)PVDLK 84.734 0.023725 6297900.0 51822.0 42455.0 48992.0 49803.0 56622.0 53877.0 55987.0 49628.0 45890.0 45458.0 True False 48941.940699902596 45711.16198565905 45839.90805845643 43019.745485032996 49508.63815289749 61298.067703289045 58590.506436135845 49772.40926364234 55069.28227373162 44145.50942593175 1.1086504909863686 1.0354657264144653 1.03838212888601 0.9744987892191485 1.1214875260634178 1.388545935937974 1.3272132816688913 1.1274625643895109 1.2474492420600107 1.0 15.429979070912825 -6.528728587283758 24.898192197180105 1.2353734901532358 1.0400515865551205 0.3926192224859034 0.1039780809275087 136.77392213108735 582133.9047460299 0.033778400909678735 0.033870680144667056 2.9598616567955506e-07 6.528728587283758 -0.1953219035981153 DVSLGDWEFGKRDS(ph)LGAYASQDANEQGQDLGKR ddPTM_A459_Selumetinib_30min_R1 1 DVSLGDWEFGKRDSLGAYASQDANEQGQDLGKR 33 3 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 DVS(0.002)LGDWEFGKRDS(0.467)LGAY(0.423)AS(0.108)QDANEQGQDLGKR 48.655 0.0088688 16341000.0 791.19 568.52 1371.3 1148.5 768.68 868.29 603.89 646.36 622.36 528.66 True False 809.6231876122542 501.9574141022223 1185.084992011717 947.9360350150909 699.1530297214761 859.5557909442416 558.3380911053716 629.2164331268247 1056.0994646240576 596.5186605844732 1.3572470420606453 0.841478141874725 1.9866687671607162 1.5891137992000057 1.1720555883975885 1.4409537332864706 0.9359943418338464 1.0548143330676596 1.7704382685854017 1.0 9.220423459483307 -6.278619129434787 24.134537252590807 1.2277265547476264 1.4394050267864338 0.08451849368465125 0.34585309726520524 1510.6556519950786 2122200.713135963 0.11007647552169363 0.12514644215840792 5.264787789757082e-07 6.278619129434787 0.2116784720388074 DVSS(ph)PDENNGQSK ddPTM_A459_Selumetinib_30min_R1 2 DVSSPDENNGQSK 13 0 J3QL74;J3QLI2;O43829 J3QL74 ZBTB14 Zinc finger and BTB domain-containing protein 14 1 DVS(0.007)S(0.993)PDENNGQSK;DVS(0.078)S(0.922)PDENNGQSK 222.56 1.0158e-50 3965300.0 5705.6 5954.799999999999 6480.3 7556.5 6480.299999999999 5656.7 6598.8 6248.9 3649.3 5263.2 True False 5838.529378835014 5257.609247688586 5600.310853739909 6236.899128072732 5894.158009189891 5599.798733872661 6101.047203275638 6083.158872712135 6192.595565673529 5938.782987909434 0.9831188293496288 0.8853007861025354 0.943006482159963 1.050198187199334 0.9924858377869012 0.9429202490262903 1.0273228059850903 1.0243106853873312 1.042738146566531 1.0 12.535951599998256 -5.635255608090688 6.819921906127079 1.009266854967387 0.9294886319683494 0.47074415568765837 0.03601550185061904 0.18180900455875482 10.13728673658094 0.009974925825444165 0.017377478940227876 2.3160311269082806e-06 5.635255608090688 -0.0797782229990377 DVSS(ph)PDENNGQSK ddPTM_A459_Selumetinib_30min_R2 2 DVSSPDENNGQSK 13 0 J3QL74;J3QLI2;O43829 J3QL74 ZBTB14 Zinc finger and BTB domain-containing protein 14 1 DVS(0.062)S(0.938)PDENNGQSK;DVS(0.005)S(0.995)PDENNGQSK 269.88 3.2969e-38 10848800.0 55940.0 53569.0 53851.0 61478.0 55463.0 44303.0 53236.0 60721.0 45453.0 58517.0 True False 52831.078745562685 57677.57004851655 50386.285288535604 53104.59034453466 48495.24209448894 50405.33610740785 55711.57948513275 60897.68805709729 54544.870062931404 56827.46216457493 0.9296751382731375 1.0149594553682455 0.8866538002808328 0.9344881562850957 0.8533768753220846 0.886989039936918 0.9803636721236904 1.0716242770218174 0.9598329396615841 1.0 15.794300667623261 -7.466258503704364 5.678942126579716 1.0146104866422583 0.9191694172536474 0.4454696957380946 0.04737366012564544 0.19683228372722322 13.73850928846778 0.021336283057804287 0.01392931395715255 3.417759477614016e-08 7.466258503704364 -0.09544106938861086 DVT(ph)PPPETEVVLIK ddPTM_A459_Selumetinib_30min_R1 9 DVTPPPETEVVLIK 14 0 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DVT(0.959)PPPET(0.041)EVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(0.998)PPPET(0.002)EVVLIK;DVT(1)PPPETEVVLIK;DVT(0.996)PPPET(0.004)EVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(0.999)PPPET(0.001)EVVLIK 214.47 1.145e-09 590128600.0 35818.77 47618.65000000001 32232.010000000002 33333.45 35361.31 32943.51 42166.09999999999 39338.97 20834.12 37701.63000000001 True False 36653.27764980621 42043.43632069021 27855.08007975761 27512.38870385176 32162.88575404635 32612.128199713825 38985.4771288781 38295.57272461656 35353.97997608037 42541.00145547497 0.8615988433692356 0.9883038687910173 0.6547819545083299 0.6467263995335717 0.7560443960800793 0.7666046186958461 0.9164212358677494 0.9002038366374182 0.8310565987282456 1.0 15.376566375655777 -7.260425584384526 24.14457953391254 0.9036040770701779 0.7758198527953735 0.29810132331014016 0.09951378220633449 86.00962187578013 2048457.0125648433 0.043461310372709 0.03168575047801646 5.49002618206202e-08 7.260425584384526 -0.1277842242748044 DVT(ph)PPPETEVVLIK ddPTM_A459_Selumetinib_30min_R2 11 DVTPPPETEVVLIK 14 0 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(0.999)PPPET(0.001)EVVLIK;DVT(0.999)PPPET(0.001)EVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK;DVT(1)PPPETEVVLIK 224.34 5.4782e-09 196964300.0 1419257.4 1144597.2 1326229.0 1362096.6 1409813.4 1206704.9 1463382.9 1517412.1 1257037.5 1201651.6 True False 1340380.7554455248 1232384.1247799285 1240900.8700289538 1176576.6933323059 1232700.036800293 1372917.5465985604 1531433.1044882038 1521827.5179899037 1508480.124562346 1166956.7960421925 1.1486121508452674 1.0560666247110748 1.0633648771210273 1.0082435762169943 1.0563373391209279 1.1764938952794968 1.3123305932851632 1.304099280411475 1.292661501846899 1.0 20.154319718810328 -6.922974964544103 3.6633700903960174 1.2523716259346682 1.0627827726060335 0.4036328947333109 0.09077831413019372 0.19391254510039518 5.1663303835169385 0.03246777474621139 0.027960891522427842 1.1940569354058921e-07 6.922974964544103 -0.18958885332863473 DVT(ph)SPINER ddPTM_A459_Selumetinib_30min_R2 1 DVTSPINER 9 0 K7ERF3;K7ELU8;D3DUE4;F6WF08;Q6ZW76-2;Q6ZW76;K7EJY2 K7ERF3 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 1 DVT(0.839)S(0.161)PINER 117.25 0.017753 79361000.0 135530.0 109610.0 144840.0 136100.0 165390.0 116000.0 133210.0 130600.0 109170.0 126470.0 True False 127997.7851695764 118016.73454830032 135521.15208986847 117562.94521440486 144612.2295946403 131977.94705684282 139404.52895060746 130980.02437800623 131007.0504646604 122818.48249147767 1.0421703848885946 0.9609037023925895 1.103426368252614 0.9572089056104606 1.1774468032909857 1.074577249120471 1.1350451994086532 1.0664520658533205 1.0666721148728648 1.0 16.906168157232607 -5.2680423391882 24.918160389534343 1.0769005841465566 1.0015370424836294 0.17287729518053419 0.061607697860905336 709.9744111761972 2679298.884775568 0.015489594043745662 0.03345157174584861 5.394580284129222e-06 5.2680423391882 -0.07536354166292725 DVTGS(ph)PPAK ddPTM_A459_Selumetinib_30min_R1 3 DVTGSPPAK 9 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 DVT(0.196)GS(0.804)PPAK;DVT(0.004)GS(0.996)PPAK;DVT(0.017)GS(0.983)PPAK 121.9 0.0061157 98698000.0 17616.5 19369.4 22185.6 22758.9 19422.5 17373.9 17201.6 16108.8 9912.5 13168.3 True False 18026.930174258112 17101.621643410235 19172.917376777626 18784.485352464035 17665.73830432088 17199.13434023905 15904.06946291239 15681.542295243198 16820.788519644535 14858.579575104079 1.2132337470845924 1.1509593872663595 1.2903600428201312 1.2642181076270513 1.1889251065371191 1.1575221072313417 1.070362707452875 1.055386365566061 1.132058985492004 1.0 13.859008585742242 -6.998113266173279 1.853028058482073 1.0664967065214532 1.2269239795789262 0.724069888217606 0.04590828226730478 0.19712193684239113 1.3630541727172736 0.021607563113609146 0.01659933156826899 1.0043538156187048e-07 6.998113266173279 0.16042727305747295 DVTGS(ph)PPAK ddPTM_A459_Selumetinib_30min_R2 2 DVTGSPPAK 9 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 DVT(0.139)GS(0.861)PPAK;DVT(0.031)GS(0.969)PPAK 112.13 0.009872399999999998 46406400.0 159571.0 157609.0 179653.0 204925.0 197241.0 160023.0 159480.0 171477.0 146721.0 201205.0 True False 150702.68263332476 169697.10350718975 168094.3215713971 177013.86148465762 172461.8222230874 182064.7157058378 166896.13600362474 171975.96968045432 176069.2997272643 195395.68885662756 0.7712692307346838 0.8684792612374664 0.8602765114983527 0.9059251128848719 0.8826285944805671 0.9317744765567912 0.8541444132172512 0.8801420885321705 0.9010910156592857 1.0 17.576039110966356 -12.385638315496426 0.01807406284475561 1.9948916948061781 1.1592864251811757e-06 0.622720932258658 0.0341472987380092 1994.7704559551496 4.031009120758742 266.8803618765614 184.45037273227945 4.114922730554201e-13 12.385638315496426 -1.994890535519753 DVTIGGSAPIY(ph)VK ddPTM_A459_Selumetinib_30min_R2 2 DVTIGGSAPIYVK 13 0 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 DVTIGGS(0.051)APIY(0.949)VK;DVTIGGSAPIY(1)VK 189.17 0.002154 6333800.0 44767.0 41313.0 40978.0 43200.0 42318.0 36005.0 38313.0 32091.0 28424.0 41779.0 True False 42279.02935649992 44481.574257767825 38341.520093472966 37316.08547584334 37001.63451227998 40964.36192915198 40094.63041576926 32184.37949704895 34109.59423291671 40572.73171512171 1.042055281201149 1.0963416160906234 0.945007113710878 0.9197331285912752 0.9119828256101683 1.0096525473507694 0.988216191536981 0.7932514804038604 0.8407024321757426 1.0 15.30822282035303 -5.346672707999771 4.700153991483404 0.9215464410780678 1.0689019748253814 0.43302074519797995 0.06568256712871733 0.20305249052509064 7.784703477279112 0.018816347239808382 0.04149028695663034 4.501189447003845e-06 5.346672707999771 0.14735553374731358 DVTNFTVGGFAPMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 DVTNFTVGGFAPMSPR 16 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR 284.84 4.335899999999998e-63 551250000.0 4111.6 4118.3 4915.4 5191.7 4246.7 3955.1 4536.4 4467.0 2575.6499999999996 3585.1 True False 4207.392280219094 3636.1275214542734 4247.915678359513 4285.0670552789215 3862.5867348157813 3915.315284943473 4194.215695723409 4348.520649139068 4370.689931966955 4045.2825068312263 1.040073783008755 0.8988562641333412 1.050091228779721 1.0592751057664758 0.9548373267610041 0.9678719047017659 1.0368165112425847 1.0749609308610133 1.0804412113582218 1.0 11.982024743058378 -7.464422735383656 5.409665378558655 1.0580686682107943 0.994597159542663 0.21279028909349607 0.04996373189534714 0.3040887739785351 18.73835761077469 0.02203109900437236 0.014327674464806846 3.432236967279115e-08 7.464422735383656 -0.06347150866813123 DVTNFTVGGFAPMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 DVTNFTVGGFAPMSPR 16 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR;DVTNFTVGGFAPMS(1)PR 207.43 7.1288e-08 208803300.0 198948.9 179576.1 194085.9 221035.0 229765.0 177210.0 177243.9 186897.40000000002 156465.9 173418.6 True False 187892.11659354786 193349.00944183074 181598.62449875 190929.65169335753 200899.86657483815 201619.06894778568 185486.09255212513 187441.24049146962 187763.45202252042 168411.5544223654 1.1156723613056052 1.1480744899303275 1.0783026445044992 1.1337087431336106 1.192910232696945 1.1971807376240822 1.1013857878595306 1.1129951334655992 1.1149083723295 1.0 17.36163159702165 -9.029984391954144 0.9026423222253176 0.9996684008415504 1.1395717136636996 0.5760991966311592 0.034955838426582925 1.3953790521818132 1.7305999030298662 0.03845913549149065 0.012332568843585606 9.332878414894922e-10 9.029984391954144 0.13990331282214918 DVTNNVHYENYR ddPTM_A459_Selumetinib_30min_R1 2 DVTNNVHYENYR 12 0 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33 E7EPK1 SEPT7 Septin-7 0 ; 132.14 0.0027053 20173000.0 6816.9 7852.4 8253.2 8161.7 8130.0 6849.7 6972.799999999999 6707.5 4116.9 6350.9 False True 6975.720506621634 6933.037357518282 7132.460771582524 6736.41230908373 7394.642935468082 6780.7982370299915 6446.836082166511 6529.595310969395 6986.078613520765 7166.099878004637 0.9734333354789896 0.9674770761705809 0.9953057999477005 0.9400388528996402 1.031892251204163 0.9462327280481708 0.8996296719159877 0.9111783846344501 0.9748787670352709 1.0 12.806972436011158 -6.977811334201448 24.953965816150244 0.936721500092192 0.9802694418700734 0.1822059339653822 0.034940354611039615 308.9976047272454 347505.76832931594 0.011860681960666294 0.01045942592049391 1.0524189653841185e-07 6.977811334201448 0.04354794177788135 DVTNNVHYENYR ddPTM_A459_Selumetinib_30min_R2 2 DVTNNVHYENYR 12 0 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33 E7EPK1 SEPT7 Septin-7 0 ; 104.94 0.013395 20522000.0 115988.0 86567.0 108827.0 109854.0 119117.0 88725.0 84964.0 90900.0 75737.0 109125.0 False True 109541.85129675239 93206.41054322352 101825.18930187871 94891.69569128002 104152.45754050893 100946.06338464124 88914.99435297202 91164.50395069487 90886.51626859019 105974.27770919992 1.0336645237379405 0.8795191867123433 0.960848155826015 0.8954219622205759 0.9828088456173282 0.9525525020481251 0.8390243016985721 0.8602512413517552 0.8576280795042407 1.0 16.693354607860662 -7.242865330947657 24.1577643808225 0.8775801757701913 0.9469565377894653 0.2022547114946356 0.05779542572625212 720.7849449031386 937467.6102408597 0.020785901074821245 0.016066356610745017 5.716558722184767e-08 7.242865330947657 0.069376362019274 DVTS(ph)PINER ddPTM_A459_Selumetinib_30min_R1 1 DVTSPINER 9 0 K7ERF3;K7ELU8;D3DUE4;F6WF08;Q6ZW76-2;Q6ZW76;K7EJY2 K7ERF3 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 1 DVT(0.225)S(0.775)PINER 121.29 0.0063098 30484000.0 1560.1 2069.9 1905.0 1646.0 1808.3 1650.0 1902.8 1963.5 1018.8 1366.3 True False 1596.4472945738416 1827.5551457295976 1646.3114634159729 1358.5569992467035 1644.7395842812944 1633.4024980801325 1759.2702640469306 1911.4216016531361 1728.829189792067 1541.6779138890145 1.035525825590033 1.185432527290628 1.0678699153593056 0.8812197327388749 1.0668503255211705 1.059496593526293 1.1411399542003042 1.239831993721316 1.1213945365740807 1.0 10.590285674706777 -7.242096545871855 4.589666510819298 1.1462729922037131 1.048771099833527 0.13601212071859126 0.08854558352555222 0.3425606212100302 19.15563683443546 0.03752106436138448 0.027260220591763272 5.726687096679001e-08 7.242096545871855 -0.09750189237018625 DVTS(ph)PINER ddPTM_A459_Selumetinib_30min_R2 2 DVTSPINER 9 0 K7ERF3;K7ELU8;D3DUE4;F6WF08;Q6ZW76-2;Q6ZW76;K7EJY2 K7ERF3 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 1 DVT(0.259)S(0.741)PINER;DVT(0.316)S(0.684)PINER 98.182 0.019927 106927000.0 307431.0 283165.0 336140.0 356267.0 346333.0 292129.0 297396.0 301025.0 277498.0 283450.0 True False 290345.21576380235 304882.84498101816 314513.1183615601 307742.82000514556 302823.55228369613 332367.11806696985 311225.5032789942 301900.9329126289 333005.35394194745 275266.06200845516 1.054780286553756 1.1075932963056423 1.1425786239928823 1.1179831533162008 1.1001121971745085 1.2074395064973928 1.1306352152828578 1.0967604604426522 1.209758120969227 1.0 18.070467223163284 -4.814898006614879 2.6935298750773793 1.1309888869835396 1.0429080801945403 0.11961004753025883 0.05627210648260678 0.7973904519031797 8.224271960596557 0.01357560251871998 0.1546869377859002 1.5314470774223562e-05 4.814898006614879 -0.08808080678899932 DVTTPGHS(ph)TPVPDGK ddPTM_A459_Selumetinib_30min_R2 1 DVTTPGHSTPVPDGK 15 0 F8VRB8;H0YHC1;A0A3B3IS46;A0A3B3IRX3;Q71F56 F8VRB8 MED13L Mediator of RNA polymerase II transcription subunit 13-like 1 DVT(0.026)T(0.325)PGHS(0.592)T(0.057)PVPDGK 94.465 0.019922 0.0 10253.0 8416.0 11400.0 14931.0 12948.0 9966.3 10730.0 11968.0 7370.3 10609.0 True False 9683.179306010978 9061.480138294817 10666.536411381516 12897.372042588355 11321.356483411331 11339.067359936318 11228.966261091637 12002.824898590947 8844.565943388188 10302.690604507676 0.9398689796405565 0.8795256002670022 1.0353156103430543 1.2518450313304996 1.0988737717172603 1.100592825234915 1.0899061897654865 1.165018475206799 0.8584714695322868 1.0 13.33073353393557 -5.409977411322225 4.820203482190307 1.0929878704090643 0.9126576390690054 0.3127233311725298 0.09824911421522912 0.23321168456929245 8.226595403513345 0.025457895113779255 0.05476632692782525 3.890653806738325e-06 5.409977411322225 -0.18033023134005888 DVTVLS(ph)VAEEQDLLKQER ddPTM_A459_Selumetinib_30min_R1 1 DVTVLSVAEEQDLLKQER 18 1 Q14966-3;Q14966;Q14966-5;A0A096LPK8 Q14966-3 ZNF638 Zinc finger protein 638 1 DVT(0.045)VLS(0.955)VAEEQDLLKQER 72.145 0.011201 3299900.0 604.92 846.51 956.11 1137.6 787.21 757.99 719.01 645.49 571.77 558.06 True False 619.0134590305798 747.400215668178 826.2755135362967 938.9395153967492 716.0069944932137 750.3653087998549 664.7744968217282 628.3695083529836 970.2519295714661 629.6924369647247 0.9830409620518546 1.1869290018327587 1.312189038698244 1.4911081351439965 1.1370741531287032 1.1916377976791395 1.0557130081252173 0.9978990876591787 1.540834656119301 1.0 9.298503529479433 DVVICPDASLEDAKK ddPTM_A459_Selumetinib_30min_R2 1 DVVICPDASLEDAKK 15 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 90.707 0.035843 0.0 23952.0 23330.0 22633.0 24504.0 24678.0 19729.0 17958.0 22415.0 14867.0 22327.0 False True 22620.843727452935 25119.335982226497 21176.817420947176 21166.512928242246 21577.729015880832 22446.490667969447 18793.082583101932 22480.223938996995 17840.815418687474 21682.361497487305 1.04328321110569 1.1585147671824165 0.976684085974735 0.9762088382621589 0.9951743041633819 1.035241971709156 0.8667451921821245 1.0367977649299016 0.8228262138676632 1.0 14.404234273472682 -5.4077718336950085 0.6284272714252901 0.943813842250586 1.1386998017610097 0.318007078654329 0.07344450565076624 2.085471816956333 1.0485865515959023 0.03821317411377012 0.26409240377333176 3.910462867341336e-06 5.4077718336950085 0.19488595951042376 DVVLS(ph)TSPK ddPTM_A459_Selumetinib_30min_R2 1 DVVLSTSPK 9 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 DVVLS(0.377)T(0.246)S(0.377)PK 113.38 0.0091489 34790000.0 206040.0 202080.0 190100.0 172070.0 172790.0 142480.0 186550.0 169370.0 127880.0 158090.0 True False 194589.1216434707 217578.8862103865 177869.1729652302 148633.76916269393 151082.575437801 162105.3266953361 195224.94464181236 169862.83865928723 153459.57326573954 153525.53093285114 1.2674707617756418 1.417216308508003 1.158564128614064 0.9681371447443698 0.9840876271183935 1.0558851398223634 1.2716122423129719 1.106414272773834 0.9995703798142835 1.0 17.228119066757962 -5.44968938059921 4.755496748983335 1.065130451636224 1.337904589158567 0.6141894639980917 0.08984129995622675 0.1520815555904167 6.364089871079812 0.02581490603442706 0.054807160508085435 3.550672523371899e-06 5.44968938059921 0.2727741375223429 DVVLST(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 DVVLSTSPK 9 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 DVVLS(0.008)T(0.848)S(0.144)PK 129.0 0.0097952 8836000.0 162720.0 147720.0 140570.0 137430.0 129660.0 116210.0 140260.0 127550.0 97671.0 141690.0 True False 153676.67381977043 159049.6490053361 131525.87924104359 118711.79692002683 113370.95162489297 132216.87265065275 146782.36791991733 127921.14938296074 117207.92915575582 137599.04154516882 1.116844071688711 1.1558921284573471 0.9558633386110351 0.8627370916755842 0.8239225386441181 0.9608851280206825 1.0667397553909121 0.929665991466727 0.8518077440043844 1.0 17.07011089532822 -5.311789157941569 5.024405805814937 0.9270741857408908 1.1371306037897835 0.5864647456297076 0.06897368382977981 0.13735741122013828 7.904213409617522 0.019795981214542253 0.044181343766046155 4.877652337656303e-06 5.311789157941569 0.21005641804889263 DVVLSTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 DVVLSTSPK 9 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 DVVLS(0.266)T(0.266)S(0.469)PK;DVVLS(0.004)T(0.003)S(0.993)PK 112.3 0.0097763 66483000.0 13337.8 16079.5 18396.9 17223.8 12263.9 13818.6 12346.400000000001 12448.8 9135.8 12505.9 True False 13648.544789159003 14196.904664843245 15898.70202693821 14215.986660768747 11154.632410367398 13679.597430284932 11415.10110785633 12118.617384598707 15502.785347568079 14111.15408278168 0.9672167640641703 1.0060767943967246 1.1266762402047386 1.0074290577065546 0.7904833541558584 0.9694173382300934 0.8089417095788747 0.8587970419361907 1.0986192381305264 1.0 13.784548363332844 -6.021623909068243 24.226263790059647 0.9097201921611746 1.036674296788429 0.2314432107822597 0.09392807975369401 659.0062400676345 738315.3534746194 0.0272241326141315 0.03552780762855095 9.514283562442058e-07 6.021623909068243 0.12695410462725443 DVVLSTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 DVVLSTSPK 9 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 DVVLS(0.063)T(0.353)S(0.584)PK;DVVLS(0.089)T(0.065)S(0.846)PK 119.03 0.007026999999999999 40129900.0 387980.0 397020.0 335900.0 321290.0 319690.0 271390.0 377620.0 318960.0 230100.0 313030.0 True False 366417.6248069973 427470.157379493 314288.5597002683 277529.7477438357 279527.68413513806 308771.5090668676 395180.0782398345 319888.1207933292 276126.4295311759 303992.0105503852 1.2053528122123636 1.4061887896512395 1.0338711176364173 0.9129507951257043 0.9195231270356287 1.0157224477966673 1.299968632479357 1.0522912105951854 0.9083344954732264 1.0 18.213673882017503 -5.27718217434468 23.030468001015578 1.0224442959120381 1.3057707562796153 0.4964827695201707 0.11591388705341009 220.59360990754243 322711.9027829561 0.03268478228589578 0.06852438194503502 5.282236303105565e-06 5.27718217434468 0.28332646036757714 DVVMLDNLPDLPPALVPS(ph)PPKR ddPTM_A459_Selumetinib_30min_R1 1 DVVMLDNLPDLPPALVPSPPKR 22 1 H3BPY8;H3BPM3;H3BRE8;Q9BWH6-2;Q9BWH6 H3BPY8 RPAP1 RNA polymerase II-associated protein 1 1 DVVMLDNLPDLPPALVPS(1)PPKR 68.461 0.0037148 8650100.0 807.98 989.82 1492.9 1279.1 1149.4 1047.0 1088.8 1177.6 664.36 760.85 True False 826.804361944601 873.931414245166 1290.1723799127064 1055.7291966807159 1045.4369729430523 1036.4681305999393 1006.670939402091 1146.3662226161102 1127.3703970654274 858.5125088065989 0.9630661795410823 1.0179600242051225 1.5027997456975313 1.2297190615757758 1.217730623862771 1.2072836679348014 1.1725757389387885 1.335293558168012 1.3131671181268663 1.0 9.745695344691448 -5.031862469619333 23.8003357523647 1.2539690922329347 0.9767895053065146 0.41937505638025663 0.12142038378796328 267.21720980909987 199604.56880767297 0.029613263033349185 0.07856023615826427 9.292606141709347e-06 5.031862469619333 -0.2771795869264201 DVVQAYPEVR ddPTM_A459_Selumetinib_30min_R1 2 DVVQAYPEVR 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ; 113.62 0.01056 28939700.0 5017.2 7332.5 6494.3 7951.1 6172.700000000001 6141.0 5571.8 5643.4 2869.1 4304.7 False True 5134.090998228238 6474.007491213228 5612.409730636401 6562.589645632119 5614.3803748787 6079.227115581876 5151.514640118084 5493.718699653327 4868.653149226948 4857.250176328797 1.0569953804826835 1.3328544456621765 1.1554705907444873 1.351091545091517 1.155876302653646 1.251577928847114 1.0605825216134321 1.1310347419258493 1.0023476190198564 1.0 12.245924080032124 -7.648342087192503 1.0693532295374488 1.0067018984958642 1.2270580249470182 0.4623785724247016 0.0884630893163022 0.44281558635039475 0.9234156955139573 0.06891336576787131 0.02939107231169549 2.2472837570779914e-08 7.648342087192503 0.220356126451154 DVWS(ph)APSSLR ddPTM_A459_Selumetinib_30min_R1 1 DVWSAPSSLR 10 0 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 1 DVWS(0.606)APS(0.389)S(0.004)LR 86.11399999999998 0.042702 0.0 1562.9 1696.7 1599.2 1855.9 1663.8 1186.5 1456.2 1454.0 648.46 1246.2 True False 1599.3125291259882 1498.04957522557 1382.0374237768103 1531.80190455769 1513.3095837677483 1174.5648872558045 1346.3576616066541 1415.435196742378 1100.3892583554798 1406.1619090159477 1.1373601566587805 1.0653464338782483 0.9828437357857176 1.0893495939096138 1.0761986753195327 0.8352984672140507 0.9574698709829614 1.0065947510503395 0.7825480489124812 1.0 10.45754700416931 -6.742155974436498 24.999092169009625 0.9193623771137298 1.0661575768088993 0.5222874751110482 0.07348426296934232 205.66609775467887 266625.9055719618 0.023784651040246456 0.023750518572021404 1.810689676750043e-07 6.742155974436498 0.14679519969516952 DVWSAPS(ph)SLR ddPTM_A459_Selumetinib_30min_R1 2 DVWSAPSSLR 10 0 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 1 DVWS(0.07)APS(0.926)S(0.004)LR;DVWS(0.155)APS(0.839)S(0.006)LR 109.39 0.010099 16137100.0 3856.7 3730.6 3752.4 3668.9 3637.6 2962.3 3231.1000000000004 3646.1 2219.64 3221.0 True False 3946.5536061681496 3293.8196176911124 3242.844690457791 3028.195488782644 3308.579722270441 2932.5019515532 2987.3755256264667 3549.393583798066 3766.56696390858 3634.4467251968913 1.08587466114374 0.9062781399038595 0.8922526413651349 0.8331929775689849 0.9103393095110517 0.8068633751659506 0.821961567056573 0.976598049763897 1.0363522287438485 1.0 11.827520042873683 -7.946055687292036 6.674123618330267 1.0146463041747436 0.8894038280512148 0.32775569331363086 0.07386794822137743 0.2261045050962006 21.34640932085394 0.04286987592628966 0.02019771668868187 1.1322551708152432e-08 7.946055687292036 -0.1252424761235288 DVYHLNR ddPTM_A459_Selumetinib_30min_R2 1 DVYHLNR 7 0 I3L2Z5;A0A087WWR2;P56270-3;P56270;P56270-2;J3QSH4;Q14119;Q9HBE1-4;Q9HBE1-2;Q9HBE1-3;Q9HBE1 I3L2Z5 MAZ;VEZF1;PATZ1 Myc-associated zinc finger protein;Vascular endothelial zinc finger 1;POZ-, AT hook-, and zinc finger-containing protein 1 0 114.19 0.019415 2594400.0 18314.0 19094.0 18166.0 20340.0 19688.0 16582.0 17621.0 22996.0 19744.0 18095.0 False True 17296.18119675072 20558.44840311327 16997.219337645318 17569.656911542894 17214.61742704684 18866.01998359111 18440.41141534909 23062.91455280727 23693.351693452965 17572.55033354382 0.9842726791759109 1.169918310825364 0.967259675745514 0.9998353442189093 0.9796311349404002 1.0736073948001856 1.0493873151780724 1.3124398061209719 1.3483160522366122 1.0 14.101035966829034 -7.718332948965883 8.579323430402281 1.247569166833001 1.0327553170238848 0.40308233112663683 0.10340859637882963 0.22178114893638612 40.392984985959124 0.047229433178063725 0.02696895324263749 1.9127889358932983e-08 7.718332948965883 -0.2148138498091161 DVYLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 DVYLSPR 7 0 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR 178.55 2.7985000000000004e-06 8254590000.0 61144.3 79495.7 63326.0 64202.7 68823.4 59650.0 71761.8 64065.8 36506.6 58196.5 True False 62568.84322390312 70188.30648745169 54726.67702481883 52990.90367894065 62598.3356217582 59049.97515786663 66348.74965024336 62366.566868953116 61949.03386343058 65666.58765691433 0.9528261701491804 1.0688587452444127 0.8334021757114467 0.8069690472695211 0.9532752934995388 0.8992392823330907 1.01038826620462 0.949745815859921 0.943387437567082 1.0 16.00287186755396 -7.247761272226177 24.356242805931092 0.9716925340736847 0.9184644269450593 0.1361821335861878 0.06973442565460897 1374.988413482674 2448408.393064993 0.029010027726326312 0.022338409744243917 5.6524760095680936e-08 7.247761272226177 -0.05322810712862547 DVYLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 DVYLSPR 7 0 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR;DVYLS(1)PR 109.48 0.015825 9000045000.0 1475694.0 1343300.0 1505160.0 1485548.0 1509247.0 1161545.0 1202064.0 1256024.0 1095049.0 1361486.0 True False 1393680.8351511336 1446326.7906097258 1408319.6442942952 1283213.7996867634 1319641.8990206285 1321537.2802943145 1257962.357844628 1259678.821894032 1314089.3982254858 1322176.3616145467 1.0540808893673388 1.093898539256575 1.0651526416449895 0.9705314940888785 0.9980831130645663 0.9995166444214357 0.9514331025465428 0.9527313136621219 0.9938835970572143 1.0 20.334483196288296 -5.729936193446603 6.259609247414895 0.9791036007048114 1.0744058720942495 0.816980607015334 0.01953929199104064 0.07001164325423095 8.042974854086308 0.005565115251609592 0.00947245134394487 1.8623607346378006e-06 5.729936193446603 0.09530227138943814 DVYLS(ph)PRDDGYSTK ddPTM_A459_Selumetinib_30min_R1 1 DVYLSPRDDGYSTK 14 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DVYLS(0.857)PRDDGY(0.014)S(0.098)T(0.031)K 104.2 0.030171 133190000.0 3521.6 2375.9 12660.0 15507.0 7151.4 6077.4 3414.9 2962.4 3078.9 1780.4 True False 3603.6464281592434 2097.7285234740566 10940.841536402206 12798.993552441447 6504.557132682216 6016.266873837699 3157.3113436482386 2883.827528768654 5224.668426041219 2008.9316825645915 1.7938123329106181 1.0442010256894887 5.446099352883512 6.371044701780162 3.23781898067262 2.994759317129871 1.5716369904712895 1.4355030356667853 2.600719811124406 1.0 10.972212788055776 -7.065806688255036 2.6388634106365703 1.6829347266865906 3.6870805919513345 0.26834737852643953 1.49882307651162 0.4471018311399983 6.137186401510189 0.7101816012341695 0.5446401980217831 8.593959679159761e-08 7.065806688255036 2.0041458652647437 DVYLSPRDDGYS(ph)TK ddPTM_A459_Selumetinib_30min_R1 2 DVYLSPRDDGYSTK 14 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DVYLS(0.013)PRDDGY(0.115)S(0.81)T(0.063)K;DVYLS(0.034)PRDDGY(0.025)S(0.754)T(0.188)K 107.46 0.024665 172735600.0 2440.25 1860.44 8085.900000000001 9544.5 4334.4 4231.8 2364.2799999999997 1881.1000000000001 1891.09 1343.25 True False 2497.1030771000687 1642.6188199049084 6987.8791926694 7877.732247454532 3942.3542853004733 4189.231934166972 2185.940456107251 1831.207117326057 3209.041610251155 1515.6692218630014 1.647525093919059 1.083758115696158 4.610424947522635 5.197527358754129 2.6010650796581363 2.7639486727966487 1.442227911325123 1.2081838773998517 2.117244029212869 1.0 10.565739220197987 -7.154731770119027 2.6577455977789284 1.4380233084226166 3.1146076402497633 0.2922782048999557 1.1762839018762405 0.4205969520964922 5.777501797795265 0.5748984410771806 0.41703093631270954 7.00274367410635e-08 7.154731770119027 1.6765843318271467 DWEDDS(ph)DEDMSNFDR ddPTM_A459_Selumetinib_30min_R1 17 DWEDDSDEDMSNFDR 15 0 A0A087WYT3;Q15185-4;Q15185;Q15185-2;B4DDC6 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 1 DWEDDS(0.957)DEDMS(0.043)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.998)DEDMS(0.002)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.998)DEDMS(0.002)NFDR;DWEDDS(0.999)DEDMS(0.001)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.999)DEDMS(0.001)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR 394.26 8.76179999999999e-267 2402596100.0 28770.720000000005 37958.95999999999 21657.719999999998 19361.9 25791.659999999996 25904.929999999997 33948.33 33124.270000000004 17924.899999999998 32776.59 True False 29441.021797924186 33514.70731655824 18716.720581340338 15980.707632876512 23458.80890688741 25644.349923994523 31387.580136142707 32245.70675680721 30417.246117102295 36983.7845975229 0.7960521649776234 0.9062000463522868 0.5060791042621946 0.4321003868800076 0.6342998468701506 0.6933944214490187 0.8486849163145133 0.8718876963978144 0.8224481741963093 1.0 15.174605244656705 -7.251663387332401 2.658651602735163 0.8836869600842234 0.6486977149135278 0.41557655287428485 0.13152522924115478 0.33829167440781505 4.748706621230559 0.06776690684162229 0.045834678184745244 5.60191626211e-08 7.251663387332401 -0.23498924517069564 DWEDDS(ph)DEDMSNFDR ddPTM_A459_Selumetinib_30min_R2 17 DWEDDSDEDMSNFDR 15 0 A0A087WYT3;Q15185-4;Q15185;Q15185-2;B4DDC6 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 1 DWEDDS(1)DEDMSNFDR;DWEDDS(0.998)DEDMS(0.002)NFDR;DWEDDS(0.891)DEDMS(0.109)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.993)DEDMS(0.007)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.991)DEDMS(0.009)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.999)DEDMS(0.001)NFDR;DWEDDS(0.999)DEDMS(0.001)NFDR;DWEDDS(1)DEDMSNFDR;DWEDDS(0.999)DEDMS(0.001)NFDR;DWEDDS(1)DEDMSNFDR 379.19 4.494599999999996e-239 3709561000.0 4793467.0 3750261.2 4299317.0 4770829.0 4731849.5 4278825.4 5133697.0 5341729.4 4439252.2 3913050.4 True False 4527065.2939087665 4037894.1750496314 4022703.624962406 4121033.8600609354 4137392.2625387455 4868194.759540295 5372424.082727616 5357272.948183091 5327226.683070034 3800070.467626069 1.1913108802787165 1.0625840255989074 1.0585865865470165 1.084462484358974 1.088767247288286 1.2810801275960262 1.4137695941422388 1.4097825274092397 1.4018757621613238 1.0 21.85759474113094 -6.839300213492893 3.9319388395843617 1.3411812096164866 1.091404811487625 0.4104317588834465 0.11937426556041036 0.1843207693323619 5.516939848238083 0.04113143788628674 0.03667217210245476 1.447770711275741e-07 6.839300213492893 -0.24977639812886165 DWEDDSDEDMS(ph)NFDR ddPTM_A459_Selumetinib_30min_R1 1 DWEDDSDEDMSNFDR 15 0 A0A087WYT3;Q15185-4;Q15185;Q15185-2;B4DDC6 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 1 DWEDDS(0.012)DEDMS(0.988)NFDR 212.43 7.5438e-07 328500000.0 1948.2 2496.0 1219.8 1283.1 1931.5 1726.1 2238.6 2234.5 1234.9 2306.5 True False 1993.589269462698 2203.7671596410814 1054.157859881786 1059.0306717700157 1756.7961660340216 1708.7370011734045 2069.740599692801 2175.2338013210765 2095.5351064725387 2602.5617422125515 0.7660103647600155 0.8467684450658076 0.40504624454580673 0.40691855820092376 0.675025740038925 0.6565596402415155 0.7952705083312352 0.8358048787237666 0.8051817071171702 1.0 11.345716674556524 -7.61747601119014 1.0148306005597052 0.9232783486399782 0.6086401688013379 0.43498702911382514 0.13575506695344589 0.5943530947609248 1.1181106683848765 0.1269588566669939 0.055802488680913684 2.412814803815293e-08 7.61747601119014 -0.3146381798386403 DWEDDSDEDMSNFDR ddPTM_A459_Selumetinib_30min_R1 1 DWEDDSDEDMSNFDR 15 0 A0A087WYT3;Q15185-4;Q15185;Q15185-2;B4DDC6 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 0 296.28 4.5738e-67 12176000.0 1071.6 1254.9 784.46 708.85 1214.1 942.88 912.0 1018.8 710.66 951.26 False True 1096.5661950293752 1107.9757246128172 677.9346407303377 585.0626542624702 1104.2848693667643 933.3954832665424 843.2071057445874 991.7781144712072 1205.9381154472214 1073.3634870570625 1.0216168224949869 1.032246520375548 0.6315983810750748 0.5450741163802668 1.028807931965789 0.8695986909576336 0.7855746128056623 0.9239909186686188 1.1235132646012125 1.0 10.06792300210998 -8.049566126477051 4.611267595636243 1.0570436807188095 0.8407676771057696 0.22888053559598664 0.15740170739996118 0.3415546769669936 15.545217835418132 0.1181754757071847 0.044060668718050255 8.921417700980093e-09 8.049566126477051 -0.2162760036130399 DWEDDSDEDMSNFDR ddPTM_A459_Selumetinib_30min_R2 3 DWEDDSDEDMSNFDR 15 0 A0A087WYT3;Q15185-4;Q15185;Q15185-2;B4DDC6 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 0 ;; 407.76 7.88069999999999e-296 40786000.0 57551.6 48701.0 58940.4 66299.7 78496.0 58978.8 65938.0 68510.5 57735.4 54996.1 False True 54353.112469308675 52436.21010160364 55148.23883345537 57269.56648663826 68634.63071685642 67102.5943437598 69004.2476536683 68709.85421247617 69284.09326186105 53408.21969597174 1.017691897964691 0.9818003745509343 1.0325796131642049 1.0722987362740675 1.2850948993911722 1.2564094951253533 1.2920154996080664 1.286503362284112 1.2972552475304984 1.0 15.704774173934892 -6.12583575632007 3.33308613461939 1.2545516875577851 1.0112384150223623 0.5953291277969253 0.08490326407327153 0.15342318668460883 3.1735190226272314 0.024427620912461236 0.03295393953152975 7.484525005402013e-07 6.12583575632007 -0.2433132725354228 DWEQFHQPR ddPTM_A459_Selumetinib_30min_R1 1 DWEQFHQPR 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 126.31 0.006792 11228000.0 3980.0 4952.1 3926.3 3841.4 4312.8 3776.1 4519.5 3863.7 2269.7 3612.4 False True 4072.726256268116 4372.305829831167 3393.1300256221175 3170.5716020086784 3922.7080014866847 3738.115862424478 4178.590476329678 3761.2221249336485 3851.515127670843 4076.086727755746 0.9991755642820975 1.0726724237878316 0.8324479463395378 0.7778469433486183 0.9623710837101079 0.9170844763851844 1.025147587728186 0.922753213105586 0.9449050976870284 1.0 11.992969033018609 DWEQFHQPR ddPTM_A459_Selumetinib_30min_R2 1 DWEQFHQPR 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 89.029 0.042729 9537700.0 44915.0 53543.0 61512.0 57762.0 65035.0 52685.0 49087.0 58806.0 50382.0 66972.0 False True 42418.80410899086 57649.57593211973 57554.38488920175 49894.715954992214 56864.721879723234 59941.88052318768 51369.64276404523 58977.11572414261 60459.80779069833 65038.34434584677 0.6522122378058298 0.8863936576485304 0.8849300434702266 0.7671584579347983 0.8743260987293954 0.9216390903870767 0.7898362616810003 0.9068053056597956 0.9296025044733351 1.0 15.989002911340636 -1.5228787491365392 0.07533658373244029 1.131736608316124 0.18564028255486606 0.4819222962780756 0.06777356477341202 213.75454690645935 1.1857751064154372 2.407332169888423 21.208723267860794 0.02999999973362303 1.5228787491365392 -0.9460963257612579 DWILPSDYDHAEAEAR ddPTM_A459_Selumetinib_30min_R1 1 DWILPSDYDHAEAEAR 16 0 O43852-5;O43852;O43852-3;O43852-9;O43852-2;O43852-4;H0Y875;O43852-15 O43852-5 CALU Calumenin 0 164.7 3.1846e-05 4491300.0 2159.1 2853.5 1946.6 1750.1 2662.2 2327.7 2665.9 2354.9 1202.5 2269.7 False True 2209.4028291227364 2519.4108934438405 1682.262411908416 1444.4778884457194 2421.404480049586 2304.2854513825 2464.809016671596 2292.440402206757 2040.5546728749105 2561.0381037501993 0.862698148023431 0.9837459621372275 0.6568673888315181 0.5640204596450674 0.9454777250302742 0.8997466488328584 0.9624257495670633 0.895121552018251 0.7967685720438402 1.0 11.32251300252621 DWILPSDYDHAEAEAR ddPTM_A459_Selumetinib_30min_R2 3 DWILPSDYDHAEAEAR 16 0 O43852-5;O43852;O43852-3;O43852-9;O43852-2;O43852-4;H0Y875;O43852-15 O43852-5 CALU Calumenin 0 ;; 187.08 1.1871e-06 5104300.0 56076.0 44407.0 61526.0 65562.0 74132.0 54386.0 66078.0 70507.0 64945.0 48368.1 False True 52959.52041001381 47812.8741089898 57567.48414444379 56632.34249924165 64818.875411511326 61877.17783304703 69150.75793107307 70712.16369693779 77935.81471491595 46971.5872775839 1.1274798975185476 1.0179105472087673 1.225580983760294 1.2056723177048803 1.3799592300012529 1.317332060068076 1.4721826946664343 1.5054241892882236 1.6592118604454529 1.0 15.519500725940699 -6.051107811097666 0.9718247532922528 1.4396414625404725 1.0684238004324422 0.3514203944545896 0.16515453428170052 0.5710401789950197 1.105821186323443 0.06934804939711152 0.1413049669341283 8.889804062107093e-07 6.051107811097666 -0.3712176621080303 DWQSYYYHHPQDR ddPTM_A459_Selumetinib_30min_R2 2 DWQSYYYHHPQDR 13 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 ; 137.95 0.00057188 6461300.0 38070.0 18670.1 21036.0 19913.0 27666.0 29510.0 29285.0 24443.0 30153.0 19107.2 False True 35954.22180628478 20102.036636166595 19682.566662265053 17200.815048158987 24190.34974282191 33574.7346348917 30646.81052712662 24514.125083243503 36184.442545213096 18555.525489532392 1.9376558118263696 1.0833450471400892 1.0607388442525356 0.9269915345627032 1.3036736554008268 1.8094197684582953 1.6516271955981634 1.321122654115751 1.9500629376206882 1.0 14.179561238057666 -6.5723969499225445 9.63514959037047 1.5718861794520025 1.2126252349452422 0.13514489482981717 0.35253205897851103 0.6335287694957967 117.70555813657607 0.11371056015810198 0.1137624137648008 2.6767206543373496e-07 6.5723969499225445 -0.35926094450676027 DWSHYFK ddPTM_A459_Selumetinib_30min_R1 2 DWSHYFK 7 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 111.04 0.021302 42280000.0 44654.0 42123.0 26966.0 42284.0 27419.0 21688.0 29330.0 21320.5 17642.2 20262.7 False True 45694.3513184413 37191.21957754857 23304.16531363523 34899.89316898397 24938.956291217626 21469.83841112844 27117.614486281513 20755.011081255754 29937.52486469336 22863.614920412 1.9985619718274144 1.6266552645769623 1.0192686237393684 1.5264381109667093 1.0907704830592129 0.9390395388421611 1.1860597976600655 0.9077746958870557 1.3093959537415918 1.0 14.480765902762613 -1.5228787452808454 0.6157659898012238 1.0731350396973331 68.8998270593987 0.7136030310449157 0.18069684687670284 93.89479102781377 0.6878175629437706 0.07682632639267384 8607.384651997638 0.029999999999964916 1.5228787452808454 67.82669201970137 DY(ph)NLTKVIDYLT(ph)NDIGSS(ph)S(ph)LT(ph)NLK ddPTM_A459_Selumetinib_30min_R1 1 DYNLTKVIDYLTNDIGSSSLTNLK 24 1 Q12955;A0A087WTF3 Q12955;A0A087WTF3 ANK3 Ankyrin-3 5 DY(0.913)NLT(0.103)KVIDY(0.468)LT(0.52)NDIGS(0.432)S(0.855)S(0.855)LT(0.855)NLK 41.615 0.038566 6926100.0 1132.3 1644.7 1297.9 1557.8 1504.8 1239.7 1256.3 1154.3 709.77 1350.8 True False 1158.6803869277348 1452.137759399714 1121.652308854378 1285.7594735276518 1368.6911056940176 1227.22974355754 1161.5362795470674 1123.6842143051763 1204.4278504502502 1524.1883379062294 0.7601950219087812 0.9527285593816504 0.7359013849923471 0.8435699457547968 0.897980303125913 0.805169356723579 0.762068735641072 0.7372344915384775 0.7902093333851165 1.0 10.573825466610984 -6.97209173554596 24.895588390478753 0.7980721110439778 0.8403237676297746 0.0 0.08895417666031569 703.636843624599 627677.68129066 0.029752949991260623 0.026239128787041315 1.0663708490969895e-07 6.97209173554596 0.04225165658579677 DYAAQT(ph)SPSPK ddPTM_A459_Selumetinib_30min_R1 1 DYAAQTSPSPK 11 0 P06576;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 DYAAQT(0.712)S(0.273)PS(0.014)PK 155.86 0.0022409 0.0 2377.0 2657.1 3494.5 3291.7 2525.7 2824.7 2853.0 2767.9 1932.6 2123.0 True False 2432.379475163144 2346.005496747722 3019.966093914496 2716.8663878617085 2297.2508809485525 2796.2860826223946 2637.7959130365225 2694.4863005936927 3279.48104848071 2395.5077297711905 1.015392037743696 0.9793353899850715 1.2606789184533131 1.134150541071814 0.9589828713130376 1.1673041367683188 1.101142726551951 1.1248080175683923 1.3690129268728986 1.0 11.226115753396247 -8.016034786901791 24.349205472010507 1.205307798293449 1.0920486412492494 0.08834525640023816 0.11882445224669112 1034.7541299249726 1571288.316458249 0.0737105106660134 0.029688972728459388 9.637518242023728e-09 8.016034786901791 -0.11325915704419964 DYAFIHFDER ddPTM_A459_Selumetinib_30min_R1 3 DYAFIHFDER 10 0 O60506-2;O60506;O60506-4;O60506-3;B7Z645;O60506-5 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 ;; 155.53 0.00073597 22340000.0 31019.0 38935.1 28424.7 32305.2 33733.4 31610.0 33477.0 30665.9 17592.2 28652.0 False True 31741.682347532816 34376.56039156309 24564.781865700767 26663.703263708743 30682.21992611549 31292.032099583652 30951.80293751266 29852.540715118368 29852.678516548873 32329.763294114073 0.9818099210553662 1.0633099932971566 0.7598194160046018 0.8247416790881087 0.9490394237343973 0.9679016766967994 0.9573779633316313 0.9233764084054799 0.9233806707760159 1.0 14.98057532420312 -6.466805544436429 24.996313670910613 0.9507673719056325 0.9053720903781199 0.07436075349955074 0.07920568140161739 959.8817702831379 427895.4490943551 0.026829399538422404 0.03042152555775468 3.413457151189045e-07 6.466805544436429 -0.0453952815275126 DYAFIHFDER ddPTM_A459_Selumetinib_30min_R2 1 DYAFIHFDER 10 0 O60506-2;O60506;O60506-4;O60506-3;B7Z645;O60506-5 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 115.0 0.0084149 0.0 14207.0 12577.0 12975.0 16384.0 16837.0 13477.0 13065.0 12868.0 14427.0 13392.0 False True 13417.43181512708 13541.615458571052 12140.202626111852 14152.470936023547 14721.785535310222 15333.334417974764 13672.548387806357 12905.443749587927 17312.80312406026 13005.33816340529 1.031686500308108 1.0412351673157374 0.9334784281328589 1.0882047631676417 1.1319802184563499 1.1790031312772813 1.0513027970528654 0.9923189683680469 1.331207455472047 1.0 13.666816292119476 -5.939620453231894 8.424347098041904 1.113665222837621 1.0062846095723108 0.21768135367429375 0.09520256501616498 0.4311797991709998 54.19900466838818 0.02608720039288406 0.038764074300797445 1.1491574760048565e-06 5.939620453231894 -0.10738061326531012 DYAFVHFEDR ddPTM_A459_Selumetinib_30min_R1 3 DYAFVHFEDR 10 0 O43390;B4DT28;O43390-4;O43390-3;O43390-2;A0A286YEZ8 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 ;; 135.8 0.002706 34357300.0 18926.2 25213.5 20039.000000000004 23496.7 22805.0 20142.2 22496.7 18719.0 11114.9 17267.0 False True 19367.143636025532 22261.491698561844 17317.813866347864 19393.44243268531 20742.291776549766 19939.587755654327 20799.755806802918 18222.511312118695 18861.173499823166 19483.387644822953 0.9940336859833352 1.1425883477957222 0.8888502442207212 0.9953834921432905 1.0646142321179615 1.023414824934338 1.0675636180923467 0.9352845431354289 0.9680643758496937 1.0 14.249956925217775 -7.769760236798227 24.953340289054314 0.9637558475450331 1.0247767888893367 0.14752207683547502 0.06302944537496656 349.40796625902993 1047816.0466297258 0.03367211901396133 0.016597887003365567 1.6991814694710226e-08 7.769760236798227 0.06102094134430358 DYAFVHFEDR ddPTM_A459_Selumetinib_30min_R2 1 DYAFVHFEDR 10 0 O43390;B4DT28;O43390-4;O43390-3;O43390-2;A0A286YEZ8 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 108.9 0.014606 2596900.0 29770.0 27646.0 32379.0 30163.0 31357.0 24324.0 23961.0 26302.0 24688.0 29753.0 False True 28115.502578752254 29766.359304099165 30295.77039158965 26054.74736592275 27417.653324863244 27674.410208712496 25075.23397782077 26378.534465469493 29626.289840354875 28893.953582422164 0.9730583424158511 1.0301933662068223 1.0485159223769325 0.9017370119184153 0.9489062563436442 0.9577924367383359 0.867836722527147 0.9129430622992714 1.0253456577288278 1.0 14.8184800020573 -5.75834018969002 24.999719629898465 0.9387984125085874 1.018549629900976 0.32871684072139884 0.04677567051524608 85.71535720161424 691411.8115189624 0.0128663989348806 0.021127268107233168 1.7444551584669612e-06 5.75834018969002 0.07975121739238855 DYASHLS(ph)PGSIIQPQR ddPTM_A459_Selumetinib_30min_R2 2 DYASHLSPGSIIQPQR 16 0 C9J0Q5;C9JE98;C9J330;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 DY(0.003)AS(0.003)HLS(0.994)PGS(0.001)IIQPQR;DY(0.134)AS(0.134)HLS(0.731)PGSIIQPQR 96.562 0.005353 7283200.0 20203.0 20725.3 23308.1 23430.0 25700.0 16023.4 18613.8 21300.4 14418.900000000001 20586.0 True False 19080.19813901686 22314.86386765704 21808.482221940485 20238.793580995578 22471.3362390849 18230.477904057032 19479.378582544974 21362.380637528953 17303.082897727356 19991.62869114856 0.9544093897394541 1.116210400483134 1.090880716066738 1.0123634193924607 1.1240372951221453 0.9119055873686125 0.9743767695710361 1.068566296801386 0.8655164201498212 1.0 14.287108390847944 -6.763349243118656 24.99991874939057 0.9690023973718873 1.0618421196955086 0.3274772295497572 0.0682124957296857 62.85416740768781 822746.4017562388 0.022575330921575213 0.020919539309278506 1.7244505966211637e-07 6.763349243118656 0.09283972232362125 DYDDMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 DYDDMSPR 8 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR 167.93 0.00022492 3031734000.0 40323.1 48203.2 50283.2 50954.4 48093.9 41710.1 44912.00000000001 41987.600000000006 25580.5 36585.4 True False 41262.549774905725 42559.54693494027 43455.01762584675 42056.170572549345 43743.81523666768 41290.534263740694 41524.25168114138 40873.95245305384 43408.240174200975 41281.49246197404 0.9995411336669631 1.0309595025941345 1.0526513222814031 1.0187657486290955 1.0596471355041677 1.0002190279766408 1.0058805824278507 0.990127779190745 1.051518188548681 1.0 15.333207509432858 -6.797374356136383 24.999648487912182 1.0087028123482293 1.0326151221630195 0.21360520247284387 0.02180478040010683 269.2214216416989 187292.97504027528 0.007482339656993608 0.006599097444359565 1.5945041130989113e-07 6.797374356136383 0.0239123098147902 DYDDMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 DYDDMSPR 8 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR;DYDDMS(1)PR 159.79 0.00045957 7648422900.0 34443669.0 34539849.0 38273201.0 39809381.0 42307554.0 31847900.0 29588799.0 31929863.0 25771551.0 31618924.0 True False 32529427.765911598 37188944.35518088 35810744.91637054 34387274.63278739 36992500.8321884 36234659.13854855 30964736.782592915 32022773.61505663 30926581.317299385 30706003.508289427 1.059383314312783 1.2111294244183002 1.1662457117450349 1.119887667032415 1.2047318636631388 1.1800512928609093 1.0084261461845283 1.0428831484504888 1.0071835401487663 1.0 24.872017417034293 -7.263887638812276 24.997716305180937 1.0181967973289758 1.1602855698759735 0.7296537216352124 0.0423760930010543 112.40474781196004 1147687.5437062765 0.016686150580698528 0.011849921013442453 5.446435454450917e-08 7.263887638812276 0.1420887725469977 DYDDMSPR ddPTM_A459_Selumetinib_30min_R2 1 DYDDMSPR 8 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 136.8 0.035622 59879000.0 161070.0 144660.0 177120.0 181110.0 149000.0 137440.0 139870.0 144280.0 106890.0 160570.0 False True 152118.37421429704 155754.95684478694 165724.2920336746 156442.50556782362 130281.28792309914 156371.11244390067 146374.232147147 144699.83091316032 128270.98675613772 155933.9268890371 0.9755309652564883 0.9988522700106339 1.062785343382036 1.003261501130209 0.8354903292841946 1.0028036589829143 0.9386939395896007 0.9279560503605415 0.8225983229898111 1.0 17.25057532697231 -6.034815356477175 24.409696721052047 0.922310539878283 1.0147004118766383 0.35568808383022843 0.05864548317080044 491.12211950951433 344334.07906813774 0.016993550423496075 0.021950944522911842 9.22963748638713e-07 6.034815356477175 0.09238987199835524 DYDEEEQGYDS(ph)EK ddPTM_A459_Selumetinib_30min_R1 2 DYDEEEQGYDSEK 13 0 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 DYDEEEQGYDS(1)EK;DYDEEEQGYDS(1)EK 233.02 4.012199999999998e-64 12512000.0 4044.4 5318.5 3852.4 3121.5099999999998 3075.6000000000004 3550.0 4274.9 4626.1 3135.8999999999996 5579.6 True False 4138.62665096753 4695.807547496428 3329.2652397184734 2576.396876499742 2797.4125230412847 3514.290223142104 3952.4408512582627 4503.400800309432 5321.393262925931 6295.7960099064185 0.6573635239222191 0.7458639924336156 0.528807673323577 0.40922496098123073 0.444330235388752 0.558196329362066 0.6277904882939516 0.7153028454580395 0.8452296190271623 1.0 12.62017308150112 -8.218562538703212 1.215579727391767 0.9925572737440035 0.554087068176842 0.7212934878372064 0.09111920364517496 0.268551104814186 0.772020418642016 0.09910707249457816 0.032285561379184494 6.045572884122414e-09 8.218562538703212 -0.43847020556716154 DYDEEEQGYDS(ph)EK ddPTM_A459_Selumetinib_30min_R2 2 DYDEEEQGYDSEK 13 0 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 DYDEEEQGYDS(1)EK;DYDEEEQGYDS(1)EK 185.67 0.00012733 77112000.0 59519.0 46784.0 47668.0 53521.0 40937.0 42708.0 69041.0 64444.0 54951.0 43817.0 True False 56211.17225343485 50372.18236573012 44601.09277699421 46231.34747112525 35794.128078576614 48590.63933537627 72251.54330214605 64631.52137072148 65942.73545922486 42551.889359761786 1.3210029707068578 1.1837825093934233 1.0481577539344282 1.0864699116002792 0.841187750230064 1.1419149670314026 1.6979632253525516 1.5188872302304581 1.549701704234597 1.0 15.376935570437045 -7.137989546489159 6.733256632544986 1.4832983981865737 1.0880659689586427 0.3940724405368976 0.202952610504911 0.2224496792585921 11.286618140375305 0.07639569355507612 0.059092217694598624 7.27797322479039e-08 7.137989546489159 -0.395232429227931 DYDS(ph)PERER ddPTM_A459_Selumetinib_30min_R1 1 DYDSPERER 9 1 P52756;C9JR02;C9J9P7;C9JFQ5;P52756-4;P52756-2;P52756-5;F8W910;P52756-3 P52756 RBM5 RNA-binding protein 5 1 DYDS(1)PERER 131.42 0.017128 9470600.0 3010.2 3327.7 2753.0 2995.8 3305.9 2690.9 2909.8 2565.9 1790.9 3131.5 True False 3080.3318031704225 2938.091336994239 2379.1577211465456 2472.6397681307876 3006.88192870405 2663.831989141716 2690.3114433065807 2497.8439967821646 3039.0264978392343 3533.4585283930687 0.8717611310330796 0.8315058216716673 0.6733226673042428 0.6997789130003698 0.8509741672478344 0.7538880017231055 0.7613819213353182 0.7069119325190222 0.8600713644773722 1.0 11.78686526109564 -8.559338191903043 4.830883073568383 0.9999217918678062 0.7677557320593955 0.5663713545314499 0.0627187337255155 0.1592692071451017 13.813812532679364 0.06310624286276219 0.016428781274101495 2.758428987870681e-09 8.559338191903043 -0.23216605980841065 DYEEVGADSADGEDEGEEY ddPTM_A459_Selumetinib_30min_R2 2 DYEEVGADSADGEDEGEEY 19 0 Q9BQE3;F5H5D3 Q9BQE3 TUBA1C Tubulin alpha-1C chain 0 ; 244.01 4.3193e-29 13788900.0 175087.0 131434.0 181891.0 198281.0 208338.0 177596.0 190877.0 192636.0 169902.0 155921.0 False True 165356.36546879404 141514.56517308013 170188.33108794683 171274.7857461968 182164.7178746486 202058.23694402643 199753.15871560015 193196.5388673935 203887.14745852095 151419.15559858966 1.092043901678806 0.9345882600761131 1.1239550928359028 1.1311302395599416 1.2030493576226582 1.3344298226023685 1.319206661310035 1.2759055358857976 1.3465082845860223 1.0 17.208188202474865 -5.997021261336328 1.3865701840946314 1.2744984875029144 1.0204608634855838 0.43016985792464024 0.10306688728282526 0.3415733370588827 1.331580951719002 0.034793482585787634 0.06305382716562592 1.0068823746753216e-06 5.997021261336328 -0.25403762401733054 DYEEVGVDSVEGEGEEEGEEY ddPTM_A459_Selumetinib_30min_R2 2 DYEEVGVDSVEGEGEEEGEEY 21 0 P68363;P68363-2 P68363 TUBA1B Tubulin alpha-1B chain 0 ; 134.56 0.00054917 34505000.0 228770.0 164711.0 215721.0 236640.0 255260.0 208436.0 255470.0 260330.0 227770.0 198048.0 False True 216055.87923887002 177343.80407066006 201841.74571926612 204409.22377323115 223191.9567466463 237146.16700638013 267349.8612042011 261087.51720004837 273330.36442553566 192329.8396494988 1.1233611988270227 0.9220815885556332 1.049456215879459 1.062805564366641 1.1604645288187756 1.2330180664558055 1.3900591904585295 1.3574987514982246 1.421154226113077 1.0 17.55322308617677 -6.583038806196121 1.5802087050188853 1.3203338189872045 1.0245215466049344 0.47037836785939924 0.11941396112188965 0.28478017388276006 1.460194371698821 0.046278259294121445 0.04852295280400392 2.61192795627575e-07 6.583038806196121 -0.29581227238227004 DYEIESQNPLAS(ph)PTNTLLGSAK ddPTM_A459_Selumetinib_30min_R1 3 DYEIESQNPLASPTNTLLGSAK 22 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 DYEIESQNPLAS(0.999)PT(0.001)NTLLGSAK;DYEIESQNPLAS(0.989)PT(0.009)NT(0.003)LLGSAK;DYEIESQNPLAS(0.995)PT(0.005)NTLLGSAK 175.79 3.4974e-16 232778000.0 19042.8 21875.5 24314.7 24124.2 22097.1 19090.3 22194.1 20615.6 12525.0 16957.199999999997 True False 19486.46018916143 19314.306290355962 21012.897291086792 19911.36133731915 20098.421206559862 18898.268914605556 20519.981168427577 20068.807319093656 21254.010210193985 19133.82179711542 1.0184301074706974 1.0094327466386122 1.098207013418232 1.0406369176241075 1.050413316256027 0.9876891880248736 1.0724455044062935 1.0488655916153244 1.110808412222079 1.0 14.223837446493064 DYEIESQNPLAS(ph)PTNTLLGSAK ddPTM_A459_Selumetinib_30min_R2 5 DYEIESQNPLASPTNTLLGSAK 22 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 DYEIESQNPLAS(0.876)PT(0.099)NT(0.025)LLGSAK;DYEIESQNPLAS(0.956)PT(0.04)NT(0.004)LLGSAK;DYEIESQNPLAS(0.856)PT(0.137)NT(0.007)LLGSAK;DYEIESQNPLAS(0.87)PT(0.108)NT(0.022)LLGSAK;DYEIESQNPLAS(0.914)PT(0.085)NT(0.001)LLGSAK 123.62 2.1364e-05 107087500.0 334658.1 317108.0 328615.3 360540.0 374658.1 287974.4 299340.7 311093.6 270710.0 357884.1 True False 316059.14254451863 341429.16393707175 307472.5493672853 311433.8300338093 327590.19999208953 327640.2596286731 313260.6356823445 311998.8308716818 324859.5642693806 347551.0561384381 0.90938910114727 0.9823856320007042 0.8846831103997894 0.8960808046279035 0.9425671256242776 0.9427111609701624 0.9013370270339938 0.8977064674705089 0.934710335450631 1.0 18.406865403430253 -11.05692065336965 2.3336778769755795 1.0064367785657606 0.9212406858884349 0.41391385929071534 0.02809961357975654 1904330.1404636207 1591320.6612204132 76891.72295473835 0.00734608038381555 8.77161065908695e-12 11.05692065336965 -0.08519609267732575 DYETATLSDIK ddPTM_A459_Selumetinib_30min_R1 1 DYETATLSDIK 11 0 O43707;O43707-2 O43707 ACTN4 Alpha-actinin-4 0 192.12 0.00027829 6556400.0 3022.6 2873.9 3076.6 3308.2 3020.0 2931.6 3025.6 2788.2 2010.5 2717.4 False True 3093.020699044221 2537.4224519601385 2658.814618554111 2730.4849726050675 2746.841533224307 2902.110765679831 2797.3765560754664 2714.2478786500005 3411.6716588898207 3066.204759717491 1.0087456453264396 0.8275450111146286 0.8671353764381621 0.8905096647415826 0.8958441292998942 0.9464830280764488 0.9123254235419055 0.8852141625727832 1.112669220174376 1.0 11.582238327374775 -8.252219772217297 24.994939913405293 1.056334612341952 0.9013749944579356 0.5772538824120556 0.052022419746655855 381.81967527851026 1035144.4845065059 0.034833878483380216 0.012756370183849963 5.594744110493796e-09 8.252219772217297 -0.15495961788401635 DYETATLSDIK ddPTM_A459_Selumetinib_30min_R2 2 DYETATLSDIK 11 0 O43707;O43707-2 O43707 ACTN4 Alpha-actinin-4 0 ; 173.24 0.002792 10974000.0 62739.0 69734.0 74468.0 73162.0 77708.0 57549.0 61202.0 58738.0 54400.0 66071.0 False True 59252.217544116196 75082.37356984938 69676.80995462791 63197.20938851043 67945.62632166581 65475.85237219186 64048.014269462314 58908.91785540061 65281.520062998476 64163.358556925894 0.9234587913839871 1.1701752411111104 1.085928347918547 0.9849423535465606 1.0589474717316159 1.0204555036516911 0.9982023340102865 0.9181083905253568 1.0174267920386453 1.0 15.969462039525053 -7.147787887233554 2.1081410275369183 0.974344411288431 1.050971240476259 0.15990319251926854 0.06492717432842 0.5226791561832037 4.557377617863059 0.030083673257534433 0.021128234470128 7.115609606464964e-08 7.147787887233554 0.07662682918782804 DYFEEYGK ddPTM_A459_Selumetinib_30min_R2 2 DYFEEYGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 145.63 0.02721 71333000.0 233511.0 187256.0 211275.0 237125.0 228710.0 211330.0 218324.0 238082.0 177676.0 180716.0 False True 220533.3934385967 201617.9330770598 197681.7965188274 204828.16593655886 199977.40510665812 240438.78923726408 228476.49860079904 238774.7792034029 213216.16468223036 175498.25952344277 1.2566129945530211 1.1488315247373038 1.1264031737729079 1.1671236312699629 1.1394836943094895 1.3700351780705076 1.3018733018846806 1.3605535453843505 1.2149189699157632 1.0 17.42109719733503 -6.735677346663318 24.999667573550163 1.2752856648821118 1.1643179357036357 0.1106263953389558 0.10353825298781895 341.43942091755395 331334.5616000432 0.03229693191949728 0.032286202966734165 1.837903282169567e-07 6.735677346663318 -0.11096772917847608 DYFGAHTYELLAK ddPTM_A459_Selumetinib_30min_R1 1 DYFGAHTYELLAK 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 130.1 0.0023309 17450000.0 6741.0 10948.0 6166.4 6401.0 7185.5 7242.6 8620.4 8085.9 3966.2 7488.5 False True 6898.052184297331 9666.203070412885 5329.036749610627 5283.185511651366 6535.572793703062 7169.746019754647 7970.156287676141 7871.435665295182 6730.3517202132825 8449.72191916701 0.8163644023183848 1.1439670042260748 0.6306759915403197 0.6252496309573455 0.7734660212755678 0.8485185771014645 0.9432448030741649 0.9315615046975609 0.796517540411173 1.0 13.044688147661622 -7.024438158035811 4.535421292324916 0.9112567437157463 0.7987985544212964 0.136205529811958 0.14178275466003148 0.5038602947415716 25.410311293703337 0.05847726049138985 0.04714961997608257 9.452829877376865e-08 7.024438158035811 -0.11245818929444984 DYFGAHTYELLAK ddPTM_A459_Selumetinib_30min_R2 1 DYFGAHTYELLAK 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 101.89 0.013697999999999998 1607600.0 31941.0 18943.0 23935.0 30273.0 30523.0 26464.0 31601.0 33728.0 26644.0 24593.0 False True 30165.84708995385 20395.86718865479 22395.048158457586 26149.765176162156 26688.427860917833 30109.175783726667 33070.50911619357 33826.14289602901 31973.54449556125 23882.936189712254 1.263071125356354 0.853993287368094 0.9377007910821457 1.0949141666855164 1.1174684573504854 1.2606982468385277 1.3846919345888018 1.416330999979804 1.338761040166162 1.0 14.54369259328516 -6.614227725053964 1.820104499155595 1.3206179077885687 1.0133887842874687 0.3717278756072653 0.146831679002284 0.30929314098080346 2.0974208068114737 0.056068736750520626 0.05711166590352519 2.4309290018516196e-07 6.614227725053964 -0.3072291235011 DYGHSSSRDDYPSR ddPTM_A459_Selumetinib_30min_R1 5 DYGHSSSRDDYPSR 14 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 ;;;; 128.68 0.00088813 41242100.0 7213.130000000001 6974.85 18607.4 18995.0 15490.2 10611.0 9871.7 9038.0 5261.74 5730.11 False True 7381.181894692265 6158.231319480205 16080.617283131945 15677.879830310527 14089.114145016936 10504.262974017141 9127.069721248732 8798.282880438526 8928.788477715461 6465.625434497973 1.1416036962656777 0.9524571724527008 2.4870938544216075 2.4248048373881472 2.1790798566590475 1.624632153599654 1.4116298281911543 1.3607783144217467 1.3809628423686657 1.0 12.658574216585617 -7.183759567506311 2.8066683522946856 1.3035652431458562 1.8574287217367795 0.22506091055494315 0.4767627347220482 0.5043520885140016 7.769291657021831 0.2351535997232133 0.16862646621216457 6.549986916465497e-08 7.183759567506311 0.5538634785909233 DYGNS(ph)PLHR ddPTM_A459_Selumetinib_30min_R2 1 DYGNSPLHR 9 0 A0A0U1RRM4;A0A087WUW5;A0A0D9SF20;K7ELW5;A6NLN1;P26599;P26599-2;P26599-3 A0A0U1RRM4;A6NLN1 PTBP1 Polypyrimidine tract-binding protein 1 1 DYGNS(1)PLHR 80.469 0.030647000000000008 3720800.0 33394.0 33115.0 36665.0 41315.0 38153.0 30749.0 31392.0 29581.0 30065.0 34080.0 True False 31538.095166773684 35654.81401849252 34306.0138178336 35687.82572764969 33359.87904785239 34984.395638369504 32851.790202067925 29667.075812601823 36078.840086287666 33096.02184952603 0.9529270711194356 1.0773141914336493 1.0365600425878647 1.0783116439162244 1.0079724747441252 1.0570574251319127 0.9926205134693069 0.8963940121711845 1.0901261864741112 1.0 15.014370194682334 -7.343488092286746 6.7444177222427975 0.9855679249848202 1.0376808308419438 0.10280291342036318 0.05548257388915428 0.4645981235928543 32.28228666068657 0.022211999243349684 0.014896664649560893 4.534317300369088e-08 7.343488092286746 0.05211290585712369 DYGNSPLHR ddPTM_A459_Selumetinib_30min_R2 1 DYGNSPLHR 9 0 A0A0U1RRM4;A0A087WUW5;A0A0D9SF20;K7ELW5;A6NLN1;P26599;P26599-2;P26599-3 A0A0U1RRM4;A6NLN1 PTBP1 Polypyrimidine tract-binding protein 1 0 119.68 0.0095821 8213700.0 61184.0 47838.0 86361.0 117140.0 150720.0 78757.0 55516.0 73893.0 86852.0 110000.0 False True 57783.63821895792 51507.020776585996 80804.62728274715 101185.32992222888 131785.20614610403 89605.06186513601 58097.604002867054 74108.01639635523 104224.82684763867 106824.01418567686 0.5409236739458313 0.48216705924436365 0.7564275495423347 0.9472151996306086 1.2336664854874364 0.8388100985363496 0.5438627676159438 0.6937392959933513 0.9756685108881942 1.0 16.70487647775588 -5.407494410263023 3.5810963472192423 0.874546599124563 0.511966563291376 0.41998915647980717 0.17516831061217655 0.264877450670897 6.099665640352213 0.053248475592553246 0.12141833898798296 3.912961634067248e-06 5.407494410263023 -0.362580035833187 DYHQQFR ddPTM_A459_Selumetinib_30min_R1 1 DYHQQFR 7 0 A0A6I8PIQ6;A0A0A0MS45;J3KNI1;Q9H9E3-3;Q9H9E3 A0A6I8PIQ6 COG4 Conserved oligomeric Golgi complex subunit 4 0 94.407 0.034359 900810.0 956.48 1081.7 1041.4 1083.8 902.88 926.58 1040.8 1128.6 518.98 812.52 False True 978.7641230139018 955.0540611313133 899.9836000007316 894.5346754456722 821.2146634164108 917.2594464673275 962.2916180471123 1098.6658617905414 880.671155200517 916.8148566150194 1.0675700943891833 1.0417087531254428 0.9816415969998232 0.9756982764746984 0.8957257373079937 1.000484928717178 1.049602993564042 1.1983508489892232 0.9605768807587293 1.0 9.840486612350292 -7.294375305282974 4.564743632318311 1.0701477099981862 0.9898326163944434 0.12040494641605981 0.0717499550371796 0.3430727466826766 17.611577358924468 0.0308695436480202 0.021074747383531257 5.077204949114883e-08 7.294375305282974 -0.08031509360374278 DYIPVDQEELR ddPTM_A459_Selumetinib_30min_R2 2 DYIPVDQEELR 11 0 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 ; 143.5 0.011552 6624300.0 42770.0 28760.0 40191.0 42120.0 45412.0 29956.0 36005.0 36424.0 28858.0 38820.0 False True 40393.01462187551 30965.799522024605 37605.154816652124 36383.18333894724 39706.938571569 34082.167086506786 37679.303842554 36529.987809682185 34630.40635988987 37699.165733526985 1.0714564589410212 0.8213921692830938 0.9975062865438623 0.9650925327132795 1.0532577524986566 0.9040562681788076 0.9994731477318788 0.9689866366776118 0.9185987457831732 1.0 15.202244977170158 DYLHYIR ddPTM_A459_Selumetinib_30min_R1 2 DYLHYIR 7 0 P62280;M0R1H5;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 ; 143.02 0.0045811 55503000.0 20467.9 27388.0 23293.0 26437.0 21813.0 19048.9 20077.5 19014.8 11374.3 17041.6 False True 20944.762246399536 24181.400227664228 20129.938539290408 21820.274233952052 19840.018001397937 18857.285361017355 18563.038010512017 18510.46573522488 19301.35635399677 19229.05535924103 1.0892247099561227 1.2575448858980594 1.0468501007053597 1.13475539106323 1.0317728890339533 0.9806662370419039 0.9653640110610561 0.9626300090882617 1.0037599868222853 1.0 14.231000270567728 -6.250956819815861 1.2258029349582034 0.9754770540864566 1.1550233105040835 0.6465489307287566 0.05193303849952001 0.2635538468016261 0.8108974899321156 0.020052151521162066 0.02939734645190764 5.611037615888632e-07 6.250956819815861 0.1795462564176269 DYLLCDYNR ddPTM_A459_Selumetinib_30min_R2 2 DYLLCDYNR 9 0 A0A6I8PRV6;B1AK87;B1AK85;B1AK88;P47756-2;P47756 A0A6I8PRV6 CAPZB F-actin-capping protein subunit beta 0 ; 154.12 0.012857 16841000.0 52671.0 49197.0 53921.0 54142.0 52668.0 41862.0 45184.0 45977.0 41827.0 43819.0 False True 49743.75667871883 52970.25170671224 50451.78156474582 46767.766199840495 46051.37498210599 47628.11051459963 47285.145530397465 46110.78545809788 50193.568744026416 42553.831614565155 1.1689606973415936 1.244782189921102 1.1855990318737217 1.0990259731119727 1.0821910327422481 1.1192437603738055 1.1111842044844886 1.0835871579262268 1.1795311218660358 1.0 15.377001419861534 -1.5228787452803376 0.0972874089670101 0.9651808045686894 1.655753725347062 0.5138892329732696 0.04568730526485012 116.9655914303822 0.8128118603872696 0.682383400933967 10.77322130484126 0.029999999999999995 1.5228787452803376 0.6905729207783726 DYLLS(ph)ESEDEGDNDGER ddPTM_A459_Selumetinib_30min_R1 1 DYLLSESEDEGDNDGER 17 0 Q9BVJ6-3;Q9BVJ6 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 DYLLS(0.948)ES(0.052)EDEGDNDGER 95.197 0.0064911000000000005 5122300.0 789.16 1206.9 984.74 1098.0 918.82 743.19 892.17 990.16 729.25 900.42 True False 807.5458925619463 1065.5955869274126 851.0177167896292 906.2549120126855 835.7128932308465 735.7141833625296 824.8728986098118 963.8977403070382 1237.4839876873418 1015.9976778335257 0.7948304510733981 1.048816951235211 0.8376177774385337 0.8919852198335222 0.8225539402933365 0.7241297882996526 0.811884629863268 0.9487204167261648 1.2179988347277575 1.0 9.98868138934905 -8.03825290673613 5.080212927392852 1.1064227537025828 0.8520150102599984 0.5541439580271402 0.09309464166543623 0.15173392592474919 9.6459331877818 0.06443334658549525 0.0246631977713621 9.156870942647289e-09 8.03825290673613 -0.25440774344258443 DYLLSES(ph)EDEGDNDGERK ddPTM_A459_Selumetinib_30min_R1 1 DYLLSESEDEGDNDGERK 18 1 Q9BVJ6-3;Q9BVJ6 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 DYLLS(0.142)ES(0.858)EDEGDNDGERK 161.08 5.7759e-06 4753500.0 663.31 671.85 873.68 947.62 651.61 990.7 900.34 812.4 495.32 705.26 True False 678.7638324234176 593.1894896654089 755.0390547807176 782.1359560304749 592.6719905510896 980.7344574836292 832.4266289321079 790.8525129528942 840.5218632585457 795.7869908141452 0.852946630516032 0.7454123986854008 0.9487954232680537 0.9828458683777874 0.7447621001503746 1.232408255983514 1.0460420169478741 0.9937992478914457 1.0562146315041336 1.0 9.636238504436777 -6.752348806957511 24.999891228109174 1.0640771190622764 0.861185621661409 0.5594458535534418 0.09341835563507563 159.2341654211958 437907.6084008848 0.03177655310326493 0.03134906264101907 1.7686878524389314e-07 6.752348806957511 -0.20289149740086743 DYLLSES(ph)EDEGDNDGERK ddPTM_A459_Selumetinib_30min_R2 2 DYLLSESEDEGDNDGERK 18 1 Q9BVJ6-3;Q9BVJ6 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 DYLLS(0.341)ES(0.659)EDEGDNDGERK;DYLLS(0.198)ES(0.802)EDEGDNDGERK 150.13 7.8188e-05 10609300.0 25210.0 22025.9 27015.0 24399.0 25093.0 14316.0 16149.599999999999 17719.4 17661.0 22290.0 True False 23808.929123625934 23715.21570556889 25276.88431170804 21075.81410937735 21940.593005733765 16287.899052291059 16900.588399825305 17770.960520395412 21193.693489570156 21646.429783624855 1.0999009703501763 1.0955716920814829 1.1677160882590236 0.9736392707734571 1.0135894567856838 0.7524519846969208 0.7807563911814365 0.8209649673425052 0.9790849438646374 1.0 14.401841475716248 -6.2668522187429 1.7611856612895516 0.855196090954083 1.112354747536489 0.5820688469381805 0.08672302214606166 0.23691671888233018 1.450341814629509 0.030827396521528883 0.040782317368297696 5.409383615528269e-07 6.2668522187429 0.257158656582406 DYLSSS(ph)FLCSDDDR ddPTM_A459_Selumetinib_30min_R1 1 DYLSSSFLCSDDDR 14 0 A0A087WUU7;Q96GX5-2;Q96GX5-3;Q96GX5 A0A087WUU7 MASTL Serine/threonine-protein kinase greatwall 1 DYLSS(0.003)S(0.859)FLCS(0.138)DDDR 211.83 3.2757e-06 3910500.0 1047.2 1056.6 1331.7 1115.5 1093.8 900.23 1125.0 1093.7 604.51 867.57 True False 1071.5977225035108 932.8927807999866 1150.8624545044888 920.6988655283704 994.8659831260749 891.1745035434417 1040.1403442573035 1064.6915231617186 1025.8093183364758 978.9310603474291 1.0946610705387094 0.9529708664764368 1.1756317693056344 0.9405145089600163 1.0162778804597234 0.9103547120337135 1.0625266542141902 1.087606233255948 1.0478871903118585 1.0 9.935063453692644 -10.69865327078827 11.811144678270777 0.9999999999555704 1.029740449452187 0.014750658841943376 0.07651188469930728 0.0 0.0 0.07220762249201175 0.017512920983969074 2.0014591439074825e-11 10.69865327078827 0.029740449496616472 DYNASAS(ph)TISPPSSMEEDK ddPTM_A459_Selumetinib_30min_R2 1 DYNASASTISPPSSMEEDK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DYNAS(0.218)AS(0.369)T(0.369)IS(0.044)PPSSMEEDK 171.07 9.9943e-08 0.0 16552.0 10179.0 11517.0 13870.0 14229.0 16253.0 23564.0 18151.0 19075.0 9890.9 True False 15632.10610290585 10959.696569356347 10776.008758761482 11980.882072915436 12441.425811126028 18491.703219955765 24659.772691180195 18203.816404940197 22890.53300003118 9605.324017355542 1.6274418306619032 1.1410022763993837 1.1218787350942736 1.2473168058951032 1.2952635214227055 1.9251514250371689 2.567302534159521 1.8951798369371322 2.3831088840596144 1.0 13.229618565949819 -6.794190639312262 4.472683470648576 2.0611348436143375 1.2623239446187762 0.3885277314062979 0.4104337823301217 0.17635710407242702 7.97937074291613 0.13719715009839697 0.12491654419036953 1.606236019673369e-07 6.794190639312262 -0.7988108989955613 DYNASAST(ph)ISPPSSMEEDKFSR ddPTM_A459_Selumetinib_30min_R1 2 DYNASASTISPPSSMEEDKFSR 22 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DY(0.005)NAS(0.056)AS(0.148)T(0.396)IS(0.396)PPSSMEEDKFSR;DYNAS(0.005)AS(0.037)T(0.856)IS(0.094)PPS(0.006)S(0.002)MEEDKFSR 87.485 0.00074235 243255000.0 3950.7999999999997 5416.3 4210.9 3976.9 3715.6 3853.3999999999996 4346.6 4290.2 2195.42 4327.9 True False 4042.8459530814257 4782.157078030444 3639.0829088180117 3282.409070658696 3379.5246360424594 3814.6382946072636 4018.732462532262 4176.409959466405 3725.4673928673897 4883.42812231594 0.827870473736824 0.9792623047275509 0.7451902265517929 0.672152633036407 0.6920393935151723 0.7811394371047263 0.8229326534300253 0.8552209339134831 0.7628795386263629 1.0 12.253678546943652 -10.164929497015057 9.375467571257186 1.000000000000522 0.7930588342965493 0.3587463198345956 0.08295038082034363 0.0 0.0 0.08899456437896927 0.02158435229648949 6.840226819102588e-11 10.164929497015057 -0.2069411657039727 DYNASASTIS(ph)PPSSMEEDKFSR ddPTM_A459_Selumetinib_30min_R1 3 DYNASASTISPPSSMEEDKFSR 22 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DYNASAS(0.002)T(0.014)IS(0.982)PPS(0.002)S(0.001)MEEDKFSR;DYNAS(0.005)AS(0.08)T(0.233)IS(0.682)PPSSMEEDKFSR;DYNAS(0.013)AS(0.309)T(0.29)IS(0.31)PPS(0.031)S(0.046)MEEDKFSR 121.97 1.7905999999999998e-05 208391200.0 3217.56 4660.2 2604.91 3022.2200000000003 3521.3900000000003 3590.8 3693.6600000000003 3594.35 1794.0 4024.5000000000005 True False 3292.5228877180994 4114.581617531799 2251.177529746405 2494.446011095608 3202.8808962519006 3554.6798121855404 3415.044252417274 3499.016161905756 3044.2869714241915 4541.083776949674 0.7250522230906176 0.9060792136047391 0.49573574069989096 0.5493063184073586 0.7053120033833272 0.782782257889389 0.7520328670772112 0.7705244681163109 0.6703877578468929 1.0 12.148820937472546 -6.647885259877188 4.521097022846058 0.7779028474375261 0.6687448595152419 0.17301431865715655 0.12867359635804507 0.4746127907535512 16.606567727587823 0.04518086979635722 0.04488092123712329 2.2496488820805937e-07 6.647885259877188 -0.10915798792228426 DYNASASTIS(ph)PPSSMEEDKFSR ddPTM_A459_Selumetinib_30min_R2 5 DYNASASTISPPSSMEEDKFSR 22 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DYNAS(0.001)AS(0.003)T(0.006)IS(0.497)PPS(0.236)S(0.236)MEEDKFS(0.022)R;DYNASAS(0.002)T(0.006)IS(0.982)PPS(0.008)S(0.002)MEEDKFSR;DY(0.001)NAS(0.007)AS(0.043)T(0.106)IS(0.617)PPS(0.195)S(0.028)MEEDKFS(0.002)R;DYNAS(0.013)AS(0.025)T(0.062)IS(0.894)PPS(0.004)S(0.002)MEEDKFSR;DYNAS(0.001)AS(0.004)T(0.003)IS(0.992)PPSSMEEDKFSR 87.958 0.00028345 414066000.0 117762.0 94608.0 110207.0 123729.0 133172.0 107522.3 133508.0 133713.0 126721.0 113767.0 True False 111217.259478637 101864.12938733345 103116.40160430878 106876.8967555699 116441.74278721448 122332.52083474136 139716.38654108316 134102.08269262125 152068.74088057393 110482.25110783512 1.006652728048458 0.9219954188651529 0.9333300197120623 0.9673671171965328 1.0539407155413827 1.1072594883619804 1.2646048133533625 1.2137884714326848 1.3764087838158612 1.0 16.7534550947738 -6.780448488537047 1.546774518554713 1.2322933523955828 0.9521771133022194 0.6040480345306252 0.0916190114638693 0.23282631075477464 1.1571239662247939 0.038687716801319404 0.03457284809768523 1.6578739648339938e-07 6.780448488537047 -0.28011623909336336 DYNASASTISPPS(ph)SMEEDK ddPTM_A459_Selumetinib_30min_R2 1 DYNASASTISPPSSMEEDK 19 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DYNASAS(0.001)T(0.002)IS(0.267)PPS(0.572)S(0.158)MEEDK 117.03 0.0004624 4777900.0 38857.0 27433.0 34832.0 37161.0 34371.0 36139.0 44079.0 48280.0 41885.0 29508.0 True False 36697.483496895424 29537.022889002128 32590.947042214124 32099.607693699385 30053.00769936139 41116.81921282108 46128.76084088148 48420.48680681574 50263.17036468181 28656.027369008607 1.2806200602873385 1.0307438120660897 1.1373156028410665 1.1201694945481173 1.0487499649677057 1.4348401710869656 1.6097402562774479 1.6897138665906748 1.754017391086151 1.0 14.80655099988637 -6.89955468725194 4.053613624949229 1.5661896623851295 1.1196253331849573 0.4518398898576399 0.20354536945764018 0.17494594623211607 5.326830933504021 0.0707733025352032 0.0618423259533057 1.26021693880102e-07 6.89955468725194 -0.4465643292001722 DYNASASTISPPS(ph)SMEEDKFSR ddPTM_A459_Selumetinib_30min_R1 1 DYNASASTISPPSSMEEDKFSR 22 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 DYNASAS(0.002)T(0.031)IS(0.316)PPS(0.324)S(0.324)MEEDKFS(0.002)R 64.538 0.013878 20433000.0 2935.5 5513.7 2597.1 2871.0 2685.7 2889.2 3696.1 3448.7 2245.1 4264.1 True False 3003.891438511319 4868.153440750413 2244.4280848491453 2369.633745344644 2442.778909198847 2860.137271183709 3417.300201252819 3357.2292730436293 3809.770724383752 4811.438770851311 0.6243229066343966 1.0117874657873007 0.46647753234362116 0.49250003132127007 0.5077023787557489 0.5944453223661518 0.7102449732823223 0.6977599493487098 0.7918152772646987 1.0 12.232252654164773 -8.547336046624496 1.0435418803889749 0.9975774739345807 0.6227564995381548 0.3880177282807029 0.14554178653347968 0.6631511798958915 1.5809884239689562 0.14859267295592224 0.048585423578514815 2.835723964308086e-09 8.547336046624496 -0.3748209743964259 DYNPYNYSDSIS(ph)PFNK ddPTM_A459_Selumetinib_30min_R1 2 DYNPYNYSDSISPFNK 16 0 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4X8;H7C5M8;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 DYNPYNYSDSIS(1)PFNK;DYNPYNYSDS(0.01)IS(0.99)PFNK 188.0 8.689200000000002e-07 17617600.0 2356.45 2825.99 2874.66 3042.09 2571.55 2599.15 2850.73 3319.35 1663.04 2276.55 True False 2411.3507001464827 2495.121777032891 2484.296961377092 2510.846088601704 2338.9537565440264 2573.0049108393796 2635.697140964109 3231.3100552316437 2822.057416364152 2568.7673679748473 0.9387189864715278 0.9713303774175484 0.9671163657515823 0.9774517225283788 0.9105354520242134 1.0016496405697777 1.0260552099126157 1.2579224166099279 1.0986037317147141 1.0 11.32686052785309 -7.5515420572091765 8.111513227446403 1.1358970248193667 0.9646139123232568 0.5505192539217465 0.0632015128049018 0.14336720615748852 34.01419806402972 0.028286441147558374 0.01642235534345339 2.808393393931935e-08 7.5515420572091765 -0.17128311249610995 DYNVTANS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 DYNVTANSK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GYU2;F5GXY2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 DYNVTANS(1)K;DYNVT(0.029)ANS(0.971)K 117.03 0.0076616 22592000.0 65246.0 50979.0 56647.0 50705.0 53662.0 38071.0 60852.0 65667.0 53119.0 47427.0 True False 61619.88852043232 54888.925376679115 53002.39369259022 43798.89152899622 46920.49981563322 43314.93467587124 63681.738575950454 65858.08009824286 63744.28426886793 46057.65927985536 1.337885804096509 1.1917437020227895 1.1507834857724162 0.9509578257736802 1.0187339206826616 0.9404501955403598 1.3826525179885443 1.4299050609167145 1.38401050477935 1.0 15.491153472591757 -7.278040256505887 24.945491588868443 1.334967459490808 1.0947219841073548 0.2695961370339235 0.15742373120763287 964.7691949366151 1449715.3400492135 0.06749225240715251 0.045647652616984884 5.271809926270041e-08 7.278040256505887 -0.2402454753834533 DYNVTANSK ddPTM_A459_Selumetinib_30min_R1 1 DYNVTANSK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GYU2;F5GXY2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 148.32 0.021399 15209000.0 3193.9 3203.7 3280.9 3936.6 3171.4 3639.6 3510.4 2724.5 2177.6 2860.4 False True 3268.3116557524463 2828.6093146402773 2835.371800693683 3249.146709134004 2884.5474299561474 3602.9889284923966 3245.607701760744 2652.2374095767614 3695.228154388696 3227.5602026554457 1.012626086126441 0.8763924255581863 0.8784876571352276 1.0066881808930468 0.8937238188718873 1.116319666331265 1.005591684731535 0.8217468437597716 1.144898289224313 1.0 11.656228290577953 -6.687444154537894 24.99999997649756 1.005839625398863 0.9314068457692057 0.16641404942208948 0.09218393561393584 84.66789309727822 28603.411572194087 0.02996748058443354 0.029967469402097748 2.053789104018425e-07 6.687444154537894 -0.07443277962965733 DYQYS(ph)DQGIDY ddPTM_A459_Selumetinib_30min_R1 2 DYQYSDQGIDY 11 0 Q15417-3;Q15417;Q15417-2 Q15417-3 CNN3 Calponin-3 1 DYQYS(0.998)DQGIDY(0.002);DYQY(0.001)S(0.997)DQGIDY(0.001) 104.81 0.012059 10817600.0 5273.299999999999 6402.799999999999 5609.1 5739.8 6151.9 5308.200000000001 5173.2 4915.8 3173.1 4218.799999999999 True False 5396.157629944386 5653.1571994190335 4847.415028580858 4737.451679390172 5595.461731206157 5254.804327459978 4782.981359032786 4785.417015231212 5384.518945945429 4760.324074591941 1.1335693842245287 1.18755721476875 1.0182951733168257 0.9951952020821755 1.1754371432549588 1.1038753339310043 1.0047596096580436 1.0052712673015696 1.1311244490023495 1.0 12.216844077710354 -5.257621382966726 24.99113809174942 1.0566576099094442 1.1605633053086577 0.3269556227799152 0.060937751422122904 388.85950900346296 2545301.2790232874 0.016215930257777723 0.039677746088807954 5.525589491124015e-06 5.257621382966726 0.10390569539921346 DYQYS(ph)DQGIDY ddPTM_A459_Selumetinib_30min_R2 1 DYQYSDQGIDY 11 0 Q15417-3;Q15417;Q15417-2 Q15417-3 CNN3 Calponin-3 1 DYQYS(1)DQGIDY 110.15 0.008987 2708800.0 21084.0 26673.0 23537.0 26247.0 27048.0 23659.0 25769.0 24252.0 22078.0 26200.0 True False 19912.235685939282 28718.733332787277 22022.655045147963 22672.113321399534 23649.988427812008 26917.812494981452 26967.30956030481 24322.56930486527 26494.216910861767 25443.537924224824 0.7826048305562419 1.1287240563131016 0.8655500312391763 0.8910755017215348 0.9295086437367983 1.0579429863546206 1.059888355173641 0.9559428950998092 1.041294531828319 1.0 14.635011670881308 -6.74579217345697 23.469881528588495 1.022564829592525 0.9265409740240986 0.2626184137783153 0.08632799837041391 175.40931436519438 263102.0267775375 0.0276205943359741 0.027508932531878114 1.7955926811399e-07 6.74579217345697 -0.0960238555684263 DYRQS(ph)SGASSSSFSSSR ddPTM_A459_Selumetinib_30min_R1 1 DYRQSSGASSSSFSSSR 17 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 DYRQS(0.575)S(0.185)GAS(0.233)S(0.004)S(0.001)S(0.001)FSSSR 119.51 0.0071336 2315900.0 298.51 483.25 418.53 480.6 313.43 317.0 337.7 346.51 65.581 244.56 True False 305.46470220065186 426.67086534316985 361.695924820728 396.67223197932276 285.080311840561 313.8112678129711 312.2270171161704 337.31942917689236 111.286167153272 275.95165821612943 1.1069500512347252 1.546179747936122 1.3107220560256332 1.4374700066800947 1.0330806260902476 1.1371965287021013 1.1314554843936815 1.222385947442645 0.4032813858509632 1.0 8.108271744603115 -7.4313480008204555 0.7473435861511936 0.8052712471474875 1.3428822684790938 0.4137272595413052 0.2250454752208605 0.6612647228912881 0.7068294613038981 0.19073925285580118 0.10693347458978865 3.703838137359416e-08 7.4313480008204555 0.5376110213316062 DYRQSS(ph)GASSSSFSSSR ddPTM_A459_Selumetinib_30min_R1 1 DYRQSSGASSSSFSSSR 17 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 DYRQS(0.234)S(0.446)GAS(0.279)S(0.029)S(0.009)S(0.003)FSSSR 109.67 0.0105 2885800.0 478.84 633.57 714.8 641.09 536.39 617.2 589.15 438.09 325.08 485.09 True False 489.99604033955353 559.3913298612977 617.7340861153477 529.135666249738 487.87361920734594 610.9915283727624 544.7099411726139 426.47043008312824 551.6370170961966 547.3560266767344 0.8952053443433494 1.0219880710140994 1.1285782123673926 0.9667120493079778 0.8913277563955307 1.1162597990971075 0.9951656958631 0.7791463129993076 1.0078212172896939 1.0 9.096335726334273 -7.5556976552377195 24.99719919787933 0.9135214066704684 1.0075103238976684 0.10549332621074703 0.09428491446618668 345.5504819427299 263191.9651280944 0.043729361562832046 0.025247377081512618 2.7816491071348126e-08 7.5556976552377195 0.09398891722719993 DYS(ph)YER ddPTM_A459_Selumetinib_30min_R2 1 DYSYER 6 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 DYS(0.999)Y(0.001)ER 95.815 0.038275 87181000.0 361480.0 336770.0 341410.0 325400.0 348730.0 299450.0 293540.0 286310.0 224340.0 348960.0 True False 341390.3887190922 362599.1761137761 319444.0522991021 281079.95865369035 304919.4197142446 340696.5193635485 307190.19163847534 287143.1146988278 269214.26858332864 338884.61809303425 1.0073941704411322 1.0699782662139934 0.9426336730674654 0.8294267241616887 0.8997735613675296 1.0053466612934814 0.9064742842773176 0.8473182297698687 0.7944127712206195 1.0 18.370434629097247 -5.435617212441604 4.653760456158055 0.8953756067416164 1.0363500030953197 0.4229655581303341 0.0649568383964827 0.20859533905277752 7.749588775667341 0.01793787541147857 0.03841976522896843 3.6676069544392233e-06 5.435617212441604 0.14097439635370324 DYSDHPS(ph)GGSYR ddPTM_A459_Selumetinib_30min_R1 1 DYSDHPSGGSYR 12 0 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 DYSDHPS(0.976)GGS(0.024)YR 124.07 0.0031428000000000003 1548100.0 1400.2 1384.8 1604.5 1803.5 1824.1 1496.6 1915.3 1889.2 548.04 1145.8 True False 1432.8219356850784 1222.666972223946 1386.617712887625 1488.5525808878672 1659.1104770710122 1481.5455628040763 1770.8273789831237 1839.0922790135487 929.9838527420922 1292.8745910371317 1.10824510406356 0.9456964973247205 1.0725075134899924 1.1513510987123388 1.2832725529396394 1.1459313788629681 1.3696822501265051 1.4224831176690125 0.7193148192324423 1.0 10.336366625035705 -5.734403509315572 3.1763169293322084 1.189609002968074 1.0245007334469385 0.05455750755235833 0.1919822045963458 0.5383293031128045 11.15140933696651 0.05403165179556518 0.09568305721217082 1.8433019846480852e-06 5.734403509315572 -0.16510826952113544 DYSDHPSGGSYR ddPTM_A459_Selumetinib_30min_R1 1 DYSDHPSGGSYR 12 0 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 92.943 0.029472 4352600.0 3290.3 4223.0 2346.7 3710.8 8124.2 4087.0 6467.8 3574.8 680.91 1414.0 False True 3366.9575881906976 3728.5691967805633 2028.031029500399 3062.778440343054 7389.367544444007 4045.888490699093 5979.928638744348 3479.9846914131044 1155.454538301252 1595.5006735263607 2.1102827745907993 2.3369273724840958 1.2710938097055537 1.9196346897013399 4.63137851776151 2.535811208250328 3.747995057581245 2.1811239250195205 0.7241955816586884 1.0 10.639793502300268 -6.055903441977224 24.998290761973923 2.6580658514016218 1.8901950123430737 0.04170616381378556 1.1155563490643865 737.7105289713653 329879.68437118316 0.3345468225603898 0.4318999599607377 8.792179743277732e-07 6.055903441977224 -0.767870839058548 DYSEADGLS(ph)ER ddPTM_A459_Selumetinib_30min_R1 2 DYSEADGLSER 11 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;Q4VXN2;Q4VXN1;Q4VXN0;Q4VXN7;Q4VXN6;Q4VXN5 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 DYSEADGLS(1)ER;DYSEADGLS(1)ER 145.14 0.00070712 38943000.0 5212.4 6585.0 4049.1000000000004 4218.3 5296.700000000001 4568.4 6559.8 6671.4 2709.5 5844.8 True False 5333.838778435158 5814.025138716551 3499.254460114232 3481.6530922979173 4817.614420208337 4522.446043775322 6064.989004674723 6494.452800238719 4597.82360594975 6595.037013173175 0.808765556248001 0.8815758163454425 0.5305890555465708 0.5279201747228306 0.7304908843703913 0.6857347479236308 0.9196292594810743 0.9847484991011354 0.6971641852450388 1.0 12.687165040965525 -7.258539109837936 24.160527617819376 0.8991145351309732 0.6893547460290061 0.3848332530602142 0.12763098681665158 182.62351923799145 1521344.8722451313 0.053184584273997575 0.03934601924701206 5.513925451905798e-08 7.258539109837936 -0.20975978910196702 DYSEADGLS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 DYSEADGLSER 11 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;Q4VXN2;Q4VXN1;Q4VXN0;Q4VXN7;Q4VXN6;Q4VXN5 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 DYSEADGLS(1)ER 184.98 2.2115e-05 42714000.0 184790.0 97442.0 148290.0 184470.0 142310.0 138420.0 195080.0 204750.0 141770.0 101280.0 True False 174520.11157298056 104915.48807458712 138749.18284594407 159344.86777150034 124431.7455324581 157486.09854834666 204151.6065436868 205345.78860181302 170127.96138476633 98355.78324295783 1.7743756982940404 1.0666936362595532 1.410686573490109 1.620086409945897 1.265118749805363 1.601187986672075 2.075644154440749 2.087785606816522 1.7297199592678483 1.0 16.58572226388484 -7.0047152312364505 15.631804822866947 1.817437826817653 1.4187256457355912 0.12423585688334127 0.33619589801263106 2.3032042127508165 7632.524057302745 0.11582559085970329 0.09814327929985865 9.892015057414093e-08 7.0047152312364505 -0.39871218108206175 DYTGCSTS(ph)ESLSPVK ddPTM_A459_Selumetinib_30min_R1 1 DYTGCSTSESLSPVK 15 0 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 DYTGCS(0.01)T(0.093)S(0.866)ES(0.032)LSPVK 194.48 9.5757e-21 0.0 972.48 937.85 964.12 682.37 995.48 1093.6 751.85 931.67 443.02 784.62 True False 995.1368918833209 828.0460860053632 833.1977995320768 563.2068891713083 905.4390097662692 1082.5993769093534 695.1373491820926 906.9590851093342 751.7725830994127 885.3336198460058 1.1240247400255896 0.935292716150769 0.9411116677993122 0.6361521538843989 1.0227093939161156 1.2228151655391328 0.7851699445266793 1.0244263459317065 0.8491404440624037 1.0 9.790077397512453 -12.116119323567 2.01177086343726 1.8316138716439536 0.9467707578733403 0.009048760432404768 0.15865394914843883 7746213.938063086 674395.4891309872 29244512.449693047 0.04278489214386806 7.653862860963796e-13 12.116119323567 -0.8848431137706133 DYTGCSTSES(ph)LSPVK ddPTM_A459_Selumetinib_30min_R1 1 DYTGCSTSESLSPVK 15 0 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 DYTGCSTSES(0.917)LS(0.083)PVK 214.65 2.7516e-07 10455000.0 1554.9 1369.8 1704.3 1124.1 1552.3 1238.6 1404.9 1839.5 987.97 1489.2 True False 1591.1261446912795 1209.423179197257 1472.8654210497855 927.7970369703642 1411.8947390808244 1226.1408085588196 1298.927261908521 1790.710484461902 1676.5129315261763 1680.3533260363909 0.9468997502117129 0.7197433780489717 0.8765212638487009 0.5521440179244012 0.840236822342117 0.7296922555276124 0.7730084154220256 1.0656749724689278 0.9977145315507702 1.0 10.71454890345502 -7.755267281151002 24.93391384788246 1.0237710835805665 0.770502867880196 0.5502290243018093 0.1010680170765354 96.0389217931274 387980.7947916687 0.046782285771837344 0.026129170183648236 1.7568420545296998e-08 7.755267281151002 -0.2532682157003705 DYTGCSTSES(ph)LSPVK ddPTM_A459_Selumetinib_30min_R2 1 DYTGCSTSESLSPVK 15 0 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 DYTGCSTSES(0.713)LS(0.287)PVK 157.37 0.00015532 27720000.0 111360.0 39733.0 78660.0 100370.0 66523.0 48846.0 149000.0 106690.0 79677.0 68175.0 True False 105171.05700940058 42780.39333826853 73599.10123853244 86699.43285209264 58165.78601683451 55574.09312015989 155928.79523789868 107000.45023651973 95614.62636138847 66206.61061007732 1.588528034289562 0.6461649817753534 1.1116578927743797 1.3095283394389035 0.8785495206725035 0.8394039901462792 2.355184683237126 1.616159613829154 1.4441854896410442 1.0 16.01468765425912 -7.2223813233136305 24.998578670364736 1.65522996058362 1.0485180954567679 0.3068730571321988 0.39541872376376935 580.80254219726 371735.2507161071 0.14582260047092324 0.11295213480392693 5.992646732026398e-08 7.2223813233136305 -0.6067118651268522 DYTGCSTSESLS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 3 DYTGCSTSESLSPVK 15 0 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 DYTGCSTSES(0.001)LS(0.999)PVK;DYTGCSTSES(0.229)LS(0.77)PVK;DYTGCSTSES(0.001)LS(0.999)PVK 263.56 1.0542e-36 45146000.0 9884.0 7397.400000000001 9673.099999999999 6119.6 9743.2 7881.299999999999 8146.3 10368.3 4440.9 8286.900000000001 True False 10114.277969083932 6531.3089690420375 8359.546150534929 5050.926739119155 8861.929280301678 7802.021277647845 7531.818032376242 10093.299003015127 7535.882949497046 9350.604336241584 1.0816710455689436 0.6984905717513501 0.8940113226836625 0.5401711544506804 0.9477386660404534 0.8343868478541375 0.8054899727907435 1.07942745089694 0.805924695186712 1.0 13.19084389508731 -7.724336032865893 24.931230258293112 0.9570073104444238 0.8200259729739626 0.14041830284190493 0.14946928522794908 290.116924707626 194941.08000472377 0.06688618208567775 0.03861552302791279 1.8865310916181253e-08 7.724336032865893 -0.13698133747046115 DYTGCSTSESLS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 3 DYTGCSTSESLSPVK 15 0 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 DYTGCSTS(0.001)ES(0.017)LS(0.982)PVK;DYTGCSTSES(0.019)LS(0.981)PVK;DYTGCSTSES(0.083)LS(0.917)PVK 255.16 9.998799999999999e-29 38337500.0 113947.0 38690.9 80317.1 99198.0 69140.4 56266.4 144194.0 101941.0 71421.3 59871.9 True False 107614.28190598199 41658.367619148186 75149.58522864636 85687.06127390506 60454.364828981605 64016.585864475426 150899.30671499047 102237.63143275889 85707.55567785728 58143.24268112195 1.8508476126138453 0.7164782302840825 1.2924904384984717 1.47372346850077 1.0397487660008002 1.101015060607558 2.5953025623729915 1.7583751218256973 1.4740759497695672 1.0 15.82732391317562 DYTYEELLNR ddPTM_A459_Selumetinib_30min_R2 2 DYTYEELLNR 10 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 ; 186.41 0.0026283 7092300.0 26050.0 28945.0 32892.0 33543.0 32905.0 24049.0 25012.0 25689.0 19220.6 25882.0 False True 24602.245286412373 31164.988427155833 30775.764530101806 28974.385535097514 28771.179725567654 27361.53145491393 26175.10756033776 25763.750736957103 23065.257068435083 25134.71941048805 0.9788151952134588 1.2399178967620188 1.2244323888199005 1.1527634369774293 1.1446787710533266 1.0885950627917766 1.0413924712211262 1.0250263914307542 0.9176651901994404 1.0 14.61739396325721 -7.325372559292802 1.1501571920325204 0.9677031852428561 1.1606639729341248 0.5249076458115538 0.07011334785008992 0.3829110488453258 0.9744714364475021 0.049039246141965406 0.026455786036944543 4.727455404505095e-08 7.325372559292802 0.19296078769126868 EAAAAPTVAPGPAQPGHVS(ph)PTPATTSPGEK ddPTM_A459_Selumetinib_30min_R2 1 EAAAAPTVAPGPAQPGHVSPTPATTSPGEK 30 0 M0QXQ4 M0QXQ4 NUMBL 1 EAAAAPTVAPGPAQPGHVS(0.578)PT(0.083)PAT(0.134)T(0.172)S(0.032)PGEK 99.774 2.979700000000001e-06 0.0 46364.0 41120.0 33520.0 47336.0 46537.0 42548.0 47676.0 43925.0 38671.0 36675.0 True False 43787.274489797455 44273.77177836062 31363.359693816514 40888.75514084536 40690.60601394141 48408.60078771164 49893.02846820175 44052.8144778248 46406.28055801862 35616.097456906304 1.2294237049069698 1.243083182595445 0.8805950660867494 1.1480414211668952 1.1424779501228344 1.3591775698133022 1.400856130533948 1.2368793220853718 1.3029580406491166 1.0 15.120241825017247 -6.653688697575232 6.569819361061094 1.2831092433109648 1.1200180064004943 0.17703778963247663 0.13700160902870576 0.3201997830213796 17.51118271996352 0.04542786020802339 0.04530560544745001 2.2197869937035473e-07 6.653688697575232 -0.16309123691047045 EAAAQEAGADTPGKGEPPAPKS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 1 EAAAQEAGADTPGKGEPPAPKSPPK 25 2 O95466;O95466-2;O95466-3;K7EK60;K7ERL1;K7EJE6 O95466 FMNL1 Formin-like protein 1 1 EAAAQEAGADT(0.053)PGKGEPPAPKS(0.947)PPK 58.938 0.0034108000000000003 24954000.0 4029.8 4758.4 5357.5 6345.2 4721.7 5279.6 4215.2 4315.1 3136.2 4551.3 True False 4123.686499374182 4201.284315879853 4629.980926640981 5237.12993415564 4294.623068683841 5226.492017493253 3897.244070323009 4200.649530579806 5321.902341014798 5135.503688416211 0.8029760564042991 0.8180861256815743 0.9015631586604638 1.0197889538992368 0.8362613151989191 1.017717508271346 0.7588825374838586 0.8179625184682296 1.0362960799773222 1.0 12.326290067173103 -10.074319097681151 0.01684527425434822 1.910210137645717 2.552091179393465e-06 0.1666299547156368 0.09292101449601001 3364.898930649659 12.974993942597326 797.1975809510182 675.7704011423656 8.427153455031578e-11 10.074319097681151 -1.9102075855545375 EAAAQEAGADTPGKGEPPAPKS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 EAAAQEAGADTPGKGEPPAPKSPPK 25 2 O95466;O95466-2;O95466-3;K7EK60;K7ERL1;K7EJE6 O95466 FMNL1 Formin-like protein 1 1 EAAAQEAGADT(0.001)PGKGEPPAPKS(0.999)PPK;EAAAQEAGADTPGKGEPPAPKS(1)PPK 81.696 6.5188e-05 17309000.0 113686.0 109177.0 107646.0 99444.0 83872.0 65488.0 66357.0 68935.0 35570.0 84970.0 True False 107367.7872411163 117550.52484061458 100720.17355610327 85899.55564953174 73335.24953480666 74508.3775591252 69442.73198390099 69135.58943719637 42684.993908839264 82516.69532142674 1.301164410703643 1.4245665605332447 1.2206035780246487 1.040996071339597 0.8887322650179378 0.9029491216158525 0.8415597802772053 0.8378375935668892 0.5172891830261583 1.0 16.332398424006314 -5.906760027480339 0.9972888918385766 0.7946022962277203 1.404658683852319 0.7743205736584138 0.11899719378046594 0.2673699946373124 0.5275422746303879 0.04799248435422006 0.11697243591665643 1.2394812815864677e-06 5.906760027480339 0.6100563876245987 EAAENSLVAYK ddPTM_A459_Selumetinib_30min_R1 2 EAAENSLVAYK 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 ; 160.18 0.0082544 11306800.0 4732.9 4834.700000000001 5563.3 5681.6 5244.1 4974.1 4485.700000000001 4859.5 4184.9 4552.5 False True 4843.167361379739 4268.651076408947 4807.834417019464 4689.415216840867 4769.772080921053 4924.065070121449 4147.340037542213 4730.6102741193845 7101.469646997265 5136.857720105203 0.942826845762929 0.8309848761630729 0.9359485270931349 0.9128956791010415 0.9285388735320799 0.958575327256797 0.8073690694818925 0.9209151843167074 1.3824540281119226 1.0 12.32667039935507 -8.156212632965461 8.24224085799667 1.1897597149093133 0.9019658788265521 0.5828033831703721 0.0970105278553295 0.17359086218100656 11.98710900409872 0.05997022883532432 0.022519255844594927 6.978906293284906e-09 8.156212632965461 -0.2877938360827612 EAAENSLVAYK ddPTM_A459_Selumetinib_30min_R2 2 EAAENSLVAYK 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 ; 160.36 0.008285700000000002 15871400.0 57255.0 51361.0 60936.0 56492.0 54292.0 43818.0 45079.0 49853.0 42678.0 50926.0 False True 54072.996309924776 55300.223548355505 57015.44410210035 48797.69214586439 47471.35358336177 49853.531759799516 47175.26282234391 49998.06397639159 51214.79252295312 49455.63405836159 1.0933637256801587 1.1181784361129985 1.1528604412354229 0.9866963203480361 0.9598775647551459 1.0080455484802475 0.9538905671833737 1.010968010588842 1.0355704359692484 1.0 15.593847263831124 -5.76874231925423 24.99948240931281 0.9915802757188257 1.1211386293246535 0.8328233270451891 0.026246778442499546 60.665396284976644 207670.7827243421 0.007568246629495478 0.011487872787512291 1.7031687529169375e-06 5.76874231925423 0.1295583536058278 EAAEPLSEPKEDQEAAELLS(ph)EPEEESER ddPTM_A459_Selumetinib_30min_R1 6 EAAEPLSEPKEDQEAAELLSEPEEESER 28 1 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 EAAEPLSEPKEDQEAAELLS(0.995)EPEEES(0.005)ER;EAAEPLSEPKEDQEAAELLS(0.987)EPEEES(0.013)ER;EAAEPLSEPKEDQEAAELLS(1)EPEEESER;EAAEPLSEPKEDQEAAELLS(0.998)EPEEES(0.002)ER;EAAEPLSEPKEDQEAAELLS(0.998)EPEEES(0.002)ER;EAAEPLSEPKEDQEAAELLS(1)EPEEESER 177.71 1.3437000000000004e-26 155400000.0 9578.49 12058.09 12619.36 13335.949999999997 10956.6 11806.859999999999 8583.8 9789.61 5756.08 8177.8 True False 9801.650180502906 10646.323217146048 10905.720225182662 11007.076679285577 9965.577464544847 11688.093708171147 7936.3170551429685 9529.957741665165 9767.647352550373 9227.500288517584 1.0622216065059111 1.1537602692241584 1.1818715669674271 1.1928557393796502 1.0799866868544783 1.2666587204245823 0.8600722630178269 1.0327778318819398 1.0585366618416616 1.0 13.171724162241926 -7.2573486537054475 24.999768026935705 0.9905781765824725 1.1554789984873939 0.5649471794765344 0.0723693702985636 267.9804432723155 1637723.1679442097 0.027761894327064225 0.02069708273282543 5.529060553464091e-08 7.2573486537054475 0.1649008219049214 EAAEPLSEPKEDQEAAELLS(ph)EPEEESER ddPTM_A459_Selumetinib_30min_R2 4 EAAEPLSEPKEDQEAAELLSEPEEESER 28 1 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 EAAEPLSEPKEDQEAAELLS(0.99)EPEEES(0.01)ER;EAAEPLSEPKEDQEAAELLS(1)EPEEESER;EAAEPLSEPKEDQEAAELLS(0.981)EPEEES(0.019)ER;EAAEPLSEPKEDQEAAELLS(1)EPEEESER 141.3 5.1836e-13 20746200.0 96583.3 85957.5 103281.7 107858.6 101167.7 84432.4 76551.2 67425.2 56635.5 108335.2 True False 91215.5868395835 92550.16385307464 96636.66786661223 93168.07261353685 88458.10907528672 96062.19669898433 80110.98248332505 67621.3961691573 67964.18252808739 105207.28128734682 0.8670083070624306 0.8796935223551449 0.9185359291119201 0.8855667732642197 0.8407983553313766 0.9130755545009758 0.7614585369288496 0.6427444502103113 0.6460026501631629 1.0 16.68287502995704 -7.362206698366841 4.845547927218474 0.7283396327399183 0.8833395332546843 0.2545902162680227 0.09614089149569444 0.24533362115455914 9.21276137807087 0.03938684735310021 0.026066084839937477 4.343034723289289e-08 7.362206698366841 0.15499990051476598 EAAFS(ph)PGQQDWSR ddPTM_A459_Selumetinib_30min_R1 3 EAAFSPGQQDWSR 13 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 EAAFS(1)PGQQDWSR;EAAFS(1)PGQQDWSR;EAAFS(1)PGQQDWSR 150.12 0.00050097 39183600.0 8943.1 11048.0 12673.8 12954.599999999999 11620.5 9896.3 11436.2 11155.3 6201.3 8468.5 True False 9151.456829756627 9754.495023924137 10952.767572200177 10692.322297959507 10569.427826765907 9796.752207121472 10573.55822666256 10859.42520647885 10523.153174968145 9555.514465175376 0.9577147167856511 1.0208236363906869 1.146224791152483 1.1189687731547238 1.1061076685390085 1.0252459187650518 1.1065399215497393 1.1364563620363421 1.1012649515961996 1.0 13.222117834094703 -5.021201454358626 4.240571550744919 1.096838424633202 0.9667278133750241 0.4908368209085914 0.044063402011334726 0.14965982885954981 6.364398892582976 0.01119070316365108 0.04068275919327472 9.523542969572793e-06 5.021201454358626 -0.1301106112581778 EAAFS(ph)PGQQDWSR ddPTM_A459_Selumetinib_30min_R2 4 EAAFSPGQQDWSR 13 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 EAAFS(1)PGQQDWSR;EAAFS(1)PGQQDWSR;EAAFS(1)PGQQDWSR;EAAFS(0.995)PGQQDWS(0.005)R 157.09 0.00036503 56155000.0 87353.5 85687.5 92085.6 97309.1 108715.0 76941.4 87551.7 86539.5 83063.4 101053.2 True False 82498.74217376669 92259.45572126147 86160.9127512206 84055.43271243948 95057.24977556877 87539.37944551186 91623.0275304024 86791.31561761445 99678.40098531012 98135.53154825474 0.8406612862049949 0.9401228511805236 0.8779787645910285 0.8565239458769134 0.9686323421892066 0.8920253252255266 0.9336376548319805 0.8844025629487505 1.0157218227966363 1.0 16.582487961532934 -8.26453575346772 24.98799909689059 1.0078609275637442 0.9016958351199429 0.5766504317434669 0.03717767062054744 193.64803039519032 1562714.3769351519 0.02977863545463185 0.008960735306894754 5.438313587423387e-09 8.26453575346772 -0.10616509244380135 EAAGPAPS(ph)PMR ddPTM_A459_Selumetinib_30min_R1 2 EAAGPAPSPMR 11 0 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 EAAGPAPS(1)PMR;EAAGPAPS(1)PMR 124.48 0.0035592 297820000.0 12001.1 12461.3 12732.3 13108.4 12397.599999999999 9897.2 10343.6 10218.6 6835.799999999999 8851.3 True False 12280.702279924448 11002.325202898803 11003.323593517682 10819.26401514306 11276.239268974055 9797.643153938603 9563.373924319862 9947.569533309263 11599.853332921684 9987.450573963131 1.2296133221364547 1.1016149838659934 1.1017149483776059 1.0832858630958768 1.1290408083090537 0.9809954083257896 0.957539048979244 0.9960068848042325 1.1614428774408176 1.0 13.285900743090714 -6.7520485623692785 24.932275727596608 1.0150936614813681 1.123468108908458 0.4258864105446212 0.06352061190876995 199.44521004585323 529519.3441112478 0.021594162566960645 0.021316662943577553 1.7699110375916474e-07 6.7520485623692785 0.10837444742708979 EAAGPAPS(ph)PMR ddPTM_A459_Selumetinib_30min_R2 3 EAAGPAPSPMR 11 0 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 EAAGPAPS(1)PMR;EAAGPAPS(1)PMR;EAAGPAPS(1)PMR 126.09 0.0032258000000000005 305420000.0 653966.0 686439.0 719099.0 897941.0 946068.0 755098.0 642750.0 770219.0 615989.0 720911.0 True False 617621.1877533189 739086.6640507316 672832.9532357941 775639.8867653742 827214.47988477 859105.8954028285 672639.1485849621 772460.2097733805 739204.0121707043 700096.426278275 0.8821944586070867 1.0556926679082328 0.9610575457620688 1.1079043652439273 1.181572207534692 1.2271250975667032 0.9607807201084053 1.1033625951781996 1.0558602849900633 1.0 19.417194116684094 -5.76300031333126 24.998866419543212 1.0992773621808247 0.9752526504363598 0.31465709769253003 0.0833443980973628 50.463700534785175 808216.5623765362 0.023608691536526213 0.03723434215254915 1.725836646847128e-06 5.76300031333126 -0.12402471174446494 EAALPPVS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 7 EAALPPVSPLK 11 0 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK 138.02 0.0012852 1415978300.0 50132.8 69043.2 51998.2 54919.6 49545.2 49922.899999999994 59989.600000000006 57408.899999999994 31872.899999999998 50054.399999999994 True False 51300.79669855233 60959.59004668717 44937.13004566737 45328.92282857185 45063.8454079155 49420.720952366464 55464.53617409598 55886.229481611736 54085.983395488394 56479.36981114419 0.9083103595187414 1.0793248977551262 0.7956379505636876 0.802574869021074 0.7978815195459874 0.8750225280065899 0.982031781862269 0.9894981064499161 0.9576237053696101 1.0 15.78543637086022 -7.261254830549054 24.999999983748175 0.9814132455181509 0.8750761612936412 0.3046283600902887 0.07831034276608144 24.36089918660484 3300376.9503663722 0.03466339057012256 0.025117779672858245 5.47955347348387e-08 7.261254830549054 -0.10633708422450971 EAALPPVS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 7 EAALPPVSPLK 11 0 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK;EAALPPVS(1)PLK 141.34 0.0010117 1290073100.0 1277043.0 1072551.0 1173873.0 1200079.0 1170177.0 934998.0 1095957.0 1126983.0 905685.0 1166094.0 True False 1206070.062468173 1154812.2129049697 1098347.2891962843 1036626.1699482525 1023168.9037448884 1063785.4874332242 1146921.1720975963 1130262.3339479193 1086847.30695325 1132425.8363439296 1.0650322729848747 1.0197685144956734 0.9699065969232308 0.9154031431277043 0.9035195691474326 0.9393864510082949 1.0128002517149073 0.9980894974959285 0.95975142218776 1.0 20.11098513920507 -5.07323605018861 2.4459940956804433 0.95910650853241 1.0641811769346183 0.49225723858746584 0.034003225067545245 0.31157889782465203 3.2919246231761976 0.010392706287356949 0.052250603705471 8.448195392639273e-06 5.07323605018861 0.10507466840220836 EAALPPVS(ph)PLKAALSEEELEK ddPTM_A459_Selumetinib_30min_R1 2 EAALPPVSPLKAALSEEELEK 21 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 EAALPPVS(1)PLKAALSEEELEK;EAALPPVS(1)PLKAALSEEELEK 134.06 2.2687e-05 62476000.0 7559.5 4819.0 17639.1 17269.5 9158.7 8877.2 6633.099999999999 6864.1 6108.0 4369.200000000001 True False 7735.621641773573 4254.7892397076785 15243.807104640771 14253.706013664 8330.297202099819 8787.903427852703 6132.759926660555 6682.041770260908 10364.829889330527 4930.029379612002 1.569082260191799 0.8630352706016803 3.0920316961357486 2.891201028661168 1.6897053872639234 1.782525569562492 1.2439601175648995 1.35537564905684 2.1023870430050557 1.0 12.267380528769177 -6.7282923109722415 2.6597163722137784 1.4781547627451002 2.0906598240913805 0.1565714678676765 0.6510299685190065 0.5863468031688888 8.492118023079376 0.26197195258532036 0.24773809393657592 1.869423462315206e-07 6.7282923109722415 0.6125050613462804 EAALPPVS(ph)PLKAALSEEELEKK ddPTM_A459_Selumetinib_30min_R1 2 EAALPPVSPLKAALSEEELEKK 22 2 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 EAALPPVS(1)PLKAALSEEELEKK;EAALPPVS(1)PLKAALSEEELEKK 84.436 0.00026244 155002000.0 15461.3 11913.2 43012.0 42981.0 20471.8 20741.0 14147.099999999999 15584.5 13569.3 10413.099999999999 True False 15821.518207547288 10518.397005703582 37171.20664800409 35475.17520329437 18620.129304589835 20532.364371321226 13079.97285710444 15171.148434409615 23026.111037539747 11749.722817183414 1.346543952884494 0.8952038417724139 3.1635815777409624 3.0192350709255544 1.5847292395152315 1.7474764886618104 1.1132154401102636 1.2911920281406577 1.9597152542071161 1.0 13.52033910272341 -6.498436290002202 24.336052671618848 1.4484114784894986 2.121027738692988 0.18348896945596926 0.6844839592632894 1058.4685204528712 1053861.768343435 0.23308478522929693 0.26284376022563805 3.173684201833657e-07 6.498436290002202 0.6726162602034893 EAANEAGDSS(ph)QDEAEDDVK ddPTM_A459_Selumetinib_30min_R2 1 EAANEAGDSSQDEAEDDVK 19 0 A0A0C4DH01;Q9NVU0-3;Q9NVU0-2;Q9NVU0-5;Q9NVU0-4;Q9NVU0 A0A0C4DH01 POLR3E DNA-directed RNA polymerase III subunit RPC5 1 EAANEAGDS(0.165)S(0.835)QDEAEDDVK 175.33 5.4791000000000014e-11 6914900.0 37613.0 32707.0 39425.0 34008.0 32100.0 24637.0 32513.0 27824.0 20402.0 25887.0 True False 35522.62003676887 35215.52173041926 36888.43842269438 29376.05173292776 28067.31102235897 28030.52311758139 34024.91892328726 27904.96323348883 24482.97007950909 25139.575047496484 1.4130159308443195 1.4008001990441834 1.4673453450585634 1.168518229820005 1.1164592467983678 1.1149959004725818 1.3534404960705817 1.1100013894732774 0.9738816202443016 1.0 14.61767264259144 -3.3063355923658517 0.1988667530203398 0.9674873862559356 2.308854463908984 0.643499327668953 0.10233134971534633 18.495462950316934 0.41063371161780954 0.2237163761083828 6.708786004536055 0.0004939288658414158 3.3063355923658517 1.3413670776530484 EAARS(ph)PDKPGGS(ph)PSASR ddPTM_A459_Selumetinib_30min_R2 1 EAARSPDKPGGSPSASR 17 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 2 EAARS(0.997)PDKPGGS(0.538)PS(0.451)AS(0.015)R 128.44 0.009673 3096200.0 18135.0 18303.0 19449.0 20121.0 17192.0 13135.0 15217.0 15476.0 11524.0 17741.0 True False 17127.129300156936 19706.78124657914 18197.6725144701 17380.485089338974 15032.187261569956 14944.227022341654 15924.620651913474 15521.03259781028 13829.122007463126 17228.77123334627 0.9941004537228629 1.1438297589346758 1.0562373989416334 1.0088058430829392 0.8725048964882169 0.8673994691749762 0.9243039121148342 0.9008786748395229 0.8026760481151943 1.0 14.072532190875947 -6.072165473145152 2.8430806518869445 0.8896386707959024 1.0716514384209597 0.6412349709975647 0.05803053188015615 0.1558767742688847 2.4730035386488622 0.017248382122853793 0.024434342600035644 8.469046684319853e-07 6.072165473145152 0.18201276762505725 EAARS(ph)PDKPGGSPS(ph)ASR ddPTM_A459_Selumetinib_30min_R1 2 EAARSPDKPGGSPSASR 17 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 2 EAARS(1)PDKPGGS(0.056)PS(0.538)AS(0.406)R;EAARS(1)PDKPGGS(0.395)PS(0.557)AS(0.048)R 214.86 6.357e-09 16860800.0 4501.1 6185.4 6048.700000000001 6851.7 4797.8 5225.8 4595.7 4965.4 3106.47 4462.8 True False 4605.966872384022 5461.210492485554 5227.319763130807 5655.179217338173 4363.839837120388 5173.233196646765 4249.042648980702 4833.701462107705 5271.452702408089 5035.643851353208 0.9146728816308721 1.0845108696513523 1.0380638340271204 1.1230300204448491 0.8665902446511803 1.0273230890339042 0.8437933210544415 0.9598974043425974 1.0468279445520183 1.0 12.29796053593665 -6.258845627698518 24.991989500037498 0.9532154929349104 1.0431005329220102 0.21156437577705223 0.07783854314937251 337.1306353469273 3248403.4357042476 0.022766452244886066 0.028043676890392364 5.510035187545e-07 6.258845627698518 0.08988503998709985 EAARS(ph)PDKPGGSPS(ph)ASR ddPTM_A459_Selumetinib_30min_R2 1 EAARSPDKPGGSPSASR 17 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 2 EAARS(1)PDKPGGS(0.138)PS(0.85)AS(0.012)R 147.28 0.0037581 3541700.0 13467.0 13335.0 15349.0 17700.0 15162.0 13137.0 12982.0 13183.0 9327.7 16203.0 True False 12718.558052672372 14357.751621216901 14361.462050727625 15289.22946579692 13257.214010000214 14946.502504187465 13585.688723344982 13221.360347436865 11193.5006377138 15735.17728955018 0.8082881952095219 0.9124620178732886 0.9126978226209852 0.9716591802210315 0.8425207905858426 0.9498782396378541 0.8633959740871375 0.8402422231503706 0.7113679389648483 1.0 13.94170581324228 -7.535732219547921 4.418421863747177 0.8337661170235081 0.9019711205973843 0.06335828588860692 0.0790002372579346 0.41319514318612294 20.023839443138733 0.036025888090770466 0.021103612682810798 2.912512382620762e-08 7.535732219547921 0.06820500357387616 EAARS(ph)PDKPGGSPSASR ddPTM_A459_Selumetinib_30min_R1 3 EAARSPDKPGGSPSASR 17 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 EAARS(1)PDKPGGSPSASR;EAARS(1)PDKPGGSPSASR;EAARS(0.998)PDKPGGS(0.001)PSASR 97.2 0.006427899999999999 399778000.0 6066.4 6619.4 7926.4 8799.8 5947.3 7030.900000000001 6261.6 6148.8 3325.3 5503.6 True False 6207.735316840427 5844.397570724428 6850.038416598612 7263.080122704212 5409.367765081097 6960.175529546426 5789.282470756919 5985.713849882763 5642.79122969725 6210.040669603734 0.9996287701021683 0.9411206595362542 1.103058543582085 1.1695704600220713 0.8710680095153501 1.1207938723516537 0.9322455002740483 0.9638767551364061 0.9086560829330799 1.0 12.600387001359614 -7.308154116820341 24.99621867878466 0.9481842787081468 1.0318427559452523 0.18653751024043186 0.08474510380554942 751.2094231816062 401955.51611613197 0.03549029335997342 0.02392762865240448 4.918649580195007e-08 7.308154116820341 0.08365847723710551 EAAS(ph)SPAGEPLR ddPTM_A459_Selumetinib_30min_R2 1 EAASSPAGEPLR 12 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 EAAS(0.933)S(0.067)PAGEPLR 131.32 0.0020419 5539000.0 38032.0 29946.0 44146.0 41283.0 38621.0 31629.0 40203.0 38833.0 24504.0 40661.0 True False 35918.33369415876 32242.761908433542 41305.694422530534 35660.18418285278 33769.084703879285 35985.607650524886 42072.5191607332 38945.99760085077 29405.484698965338 39487.01128003455 0.9096240138164068 0.8165409551959721 1.046057756298602 0.9030864334086309 0.8551947490883827 0.9113277121765848 1.0654774265482567 0.986298945864831 0.7446875249794699 1.0 15.269090555789182 -7.036756188954346 24.929927992491653 0.9537496858217315 0.9061858892302931 0.04476636121843791 0.09466282170545984 1987.446230394639 1347981.9048669455 0.03654475014186465 0.028317129423580743 9.188482891756237e-08 7.036756188954346 -0.04756379659143839 EAAS(ph)SPAGEPLRK ddPTM_A459_Selumetinib_30min_R2 1 EAASSPAGEPLRK 13 1 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 EAAS(0.519)S(0.481)PAGEPLRK 110.64 0.015208 0.0 11052.0 8679.4 12551.0 13883.0 15449.0 13256.0 6685.4 10680.0 12926.0 14868.0 True False 10437.774084661409 9345.082071330326 11743.482324495562 11992.111450489188 13508.15850418765 15081.89367401302 6996.284346868782 10711.07703183082 15511.56118261614 14438.722208296746 0.7229015098485432 0.6472236210736485 0.8133325203630242 0.8305521276389893 0.9355508270964326 1.0445449019960158 0.48455010394538883 0.7418299817192996 1.0743029029052809 1.0 13.817655452430891 -5.204488052446461 0.041901483477743924 1.517453962941528 7.913829479663325e-11 0.18005122958148279 0.16147983654665013 632.8644568015168 4.806284537243833 66.01058187686709 111.57717018183082 6.244705293899996e-06 5.204488052446461 -1.5174539628623898 EAASGT(ph)TPQK ddPTM_A459_Selumetinib_30min_R1 1 EAASGTTPQK 10 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 EAAS(0.004)GT(0.619)T(0.378)PQK 122.18 0.010631 26694000.0 2895.7 6018.5 5913.4 3675.8 3181.1 3369.4 2645.8 4572.1 4971.5 3917.9 True False 2963.1641759486383 5313.851222075262 5110.3927599811095 3033.8905333116854 2893.370066668821 3335.5068951704243 2446.2251758542 4450.833055726155 8436.27239600634 4420.800628577743 0.670277722273566 1.20201105377259 1.1559880640048728 0.6862762626523935 0.6544900595527815 0.7545029001327123 0.5533443784007962 1.006793436228332 1.9083132456756937 1.0 12.110091957056763 -8.016517330192341 23.455184828984265 1.455289242842881 0.8230027350284551 0.4418169240788904 0.285459106188154 290.21589409242574 412112.1302858538 0.18281156787671224 0.07333076674170128 9.62681597126903e-09 8.016517330192341 -0.6322865078144259 EAASGT(ph)TPQK ddPTM_A459_Selumetinib_30min_R2 1 EAASGTTPQK 10 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 EAAS(0.022)GT(0.729)T(0.249)PQK 99.752 0.042465 6570400.0 21538.0 22891.0 30712.0 22706.0 22043.0 35111.0 58157.0 236590.0 35625.0 73642.0 True False 20341.0041834453 24646.66609383396 28736.023356697286 19613.40362996524 19273.761273079705 39947.221544075976 60861.41573590926 237278.43773041732 42750.99544566767 71515.76411510534 0.28442685938034934 0.34463263308163644 0.4018138338065768 0.2742528709949497 0.2695036753303564 0.5585792452665475 0.8510209810238788 3.317848039049339 0.5977842224668048 1.0 16.12597366764915 -7.534860810093998 24.999903666153294 1.7915768700285908 0.3791428029988316 0.42018334704281257 0.6668683991873421 183.8806749402952 383651.58963070187 0.28906856399880226 0.1670446686165219 2.918362189299896e-08 7.534860810093998 -1.4124340670297593 EAASGTT(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 EAASGTTPQK 10 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 EAAS(0.069)GT(0.247)T(0.684)PQK 132.5 0.0056814 24804000.0 3657.1 10296.0 8246.4 5520.0 4635.3 4856.4 3643.9 6818.7 7194.6 5405.8 True False 3742.30331452214 9090.539533519455 7126.584174232793 4556.035623233173 4216.037933428682 4807.549025258397 3369.037689279279 6637.845925740893 12208.710727206526 6099.68708695106 0.6135238187099754 1.4903288322718498 1.1683524208116434 0.7469294011785965 0.6911892156645163 0.7881632216090382 0.552329593510886 1.088227286271964 2.001530661027576 1.0 12.574519519192842 -8.013022120894615 24.187523238470305 1.515470067236201 0.881356026515567 0.34591082742046075 0.3461344272292217 432.73368810117086 803761.1875028154 0.21546392890397725 0.08984694101430306 9.704605353441902e-09 8.013022120894615 -0.6341140407206339 EAASGTT(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 EAASGTTPQK 10 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 EAAS(0.003)GT(0.336)T(0.661)PQK;EAAS(0.003)GT(0.295)T(0.702)PQK 145.14 0.0021342 24042000.0 47816.0 45839.0 52545.0 39671.0 45725.0 58123.0 107084.0 373380.0 69414.0 126489.0 True False 45158.57814261395 49354.70390438407 49164.31190667029 34267.74136370788 39980.61671331351 66128.91566193855 112063.61818292044 374466.4739836139 83298.73958920923 122836.9339121094 0.367630294117608 0.4017904251802448 0.40024046791861206 0.2789693642811588 0.3254771626090887 0.5383471693395914 0.9122957942201868 3.0484843772765204 0.6781245423205533 1.0 16.9063848817281 -7.530936798613844 24.99955608632495 1.7140608934279804 0.4081034440358542 0.45006413059635897 0.5836042335957855 146.73692902765598 455233.9005863726 0.2537509091549834 0.146828617548676 2.944850156558608e-08 7.530936798613844 -1.3059574493921262 EAASQRPLS(ph)SSASNR ddPTM_A459_Selumetinib_30min_R1 1 EAASQRPLSSSASNR 15 1 A0A087X2H1;Q9ULT8;H0YJP0 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 EAASQRPLS(0.88)S(0.09)S(0.029)ASNR 102.15 0.030763 2010100.0 934.18 1256.8 849.95 975.19 1155.9 752.44 910.51 997.62 479.17 731.05 True False 955.944576402148 1109.6532717295313 734.531458441158 804.8913730834705 1051.3490490907195 744.8711367608579 841.8294976441938 971.1598768735429 813.1164928078764 824.8873885300186 1.1588788841900934 1.3452178893254467 0.8904627087948593 0.9757590966662956 1.2745364563813546 0.902997363177351 1.0205386933413623 1.1773241904015377 0.985730299813265 1.0 9.688053369620008 -5.252652507868296 24.993350195640332 1.036900078189189 1.2520483870987964 0.3605187004237077 0.11870587148467836 705.0095072384232 2005315.6654796123 0.029947870616965577 0.07661634636555922 5.589172224231038e-06 5.252652507868296 0.21514830890960734 EAASQRPLSS(ph)SASNR ddPTM_A459_Selumetinib_30min_R1 1 EAASQRPLSSSASNR 15 1 A0A087X2H1;Q9ULT8;H0YJP0 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 EAASQRPLS(0.27)S(0.67)S(0.059)AS(0.001)NR 165.89 0.00039535 2419700.0 638.34 548.71 764.08 678.81 894.19 579.95 525.67 584.97 250.98 454.3 True False 653.2120800065798 484.4667781116419 660.3221327910111 560.2685763418315 813.3106723820665 574.1162295524687 486.01828868065485 569.4546953496485 425.8947291460669 512.6138302567367 1.2742771291976769 0.9450911183356139 1.2881473222450834 1.0929642223293652 1.5865952582175344 1.1199780334934177 0.9481177837851901 1.1108843767723624 0.830829571907497 1.0 9.00172859266025 -7.003052938914517 24.999497193165332 0.9891767817107188 1.2297000391214459 0.3605539488989864 0.16557955235351351 153.45653533667183 1256613.9729759234 0.05908917320096431 0.051138391106962 9.929949985720533e-08 7.003052938914517 0.2405232574107271 EAASS(ph)PAGEPLR ddPTM_A459_Selumetinib_30min_R1 1 EAASSPAGEPLR 12 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 EAAS(0.048)S(0.952)PAGEPLR 116.98 0.0048785 9599700.0 3258.7 3762.3 3799.2 3983.9 3770.9 3282.6 3671.1 3527.8 2065.7 3041.6 True False 3334.621369673596 3321.8081669541816 3283.2895075117904 3288.18665206497 3429.8227608064694 3249.580024362331 3394.1859713804315 3434.23128409062 3505.342027241334 3432.0189876929135 0.97162089767901 0.9678874676585579 0.9566641441336831 0.9580910431603903 0.999360077291437 0.9468420879998621 0.9889764548365992 1.0006446049411848 1.021364403813427 1.0 11.74484181925206 -7.615328902413448 2.743541305187182 1.0093460370090466 0.9673595897511708 0.6235336771694538 0.014152598970982788 0.17473233499271723 2.6437059707642736 0.007725690201696255 0.003958191081432415 2.4247730563710127e-08 7.615328902413448 -0.041986447257875814 EAASS(ph)PAGEPLR ddPTM_A459_Selumetinib_30min_R2 3 EAASSPAGEPLR 12 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 EAAS(0.092)S(0.908)PAGEPLR;EAAS(0.037)S(0.963)PAGEPLR;EAAS(0.01)S(0.99)PAGEPLR 158.86 0.00045796 242897700.0 255971.0 217192.0 275375.0 303476.0 308696.0 245891.0 244929.0 275012.0 203701.0 248680.0 True False 241745.1565531004 233849.92801764887 257657.67230562985 262142.04527469995 269914.8487027451 279760.25327374286 256318.6838176063 275812.23938931286 244446.89188148658 241499.96225176478 1.0010152974727176 0.968322834658911 1.0669056421508696 1.0854744772233782 1.1176600036953948 1.1584277308585729 1.061361175495311 1.1420798447238572 1.0122026090697671 1.0 17.881663437993943 -5.384797230021178 3.6727965922133503 1.0914132826114327 0.9845823994358699 0.3720337708215412 0.048977018579951334 0.21011464778778183 5.019053856816734 0.012574629460925881 0.0288994986201355 4.122899703460847e-06 5.384797230021178 -0.10683088317556277 EAASSSSGTQPAPPAPAS(ph)PWDSKK ddPTM_A459_Selumetinib_30min_R1 4 EAASSSSGTQPAPPAPASPWDSKK 24 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 EAASSSSGTQPAPPAPAS(0.995)PWDS(0.005)KK;EAASSSSGTQPAPPAPAS(0.997)PWDS(0.002)KK;EAASSSSGTQPAPPAPAS(1)PWDSKK;EAASSSSGTQPAPPAPAS(0.999)PWDS(0.001)KK 184.95 1.5517e-21 166386000.0 10161.79 12277.16 13818.300000000001 14030.8 10798.4 10898.130000000001 10860.78 10416.5 5814.39 10217.2 True False 10398.539935598688 10839.744399703159 11941.850758488683 11580.584170735501 9821.686626612363 10788.504706910326 10041.542620535856 10140.22058243947 9866.595163756467 11528.677143955814 0.9019716491107024 0.9402418217068517 1.0358387705175252 1.0045024269594454 0.8519352657699863 0.9357972794447157 0.8710056232080691 0.8795649714031348 0.8558306421937808 1.0 13.492939360245591 -6.256998728503449 24.988835670535604 0.8934384608625348 0.9731246145469143 0.30137371571717386 0.052956452579008904 445.4031156935227 2506411.1457564807 0.015881671397090638 0.019804605311031193 5.533517292772725e-07 6.256998728503449 0.07968615368437959 EAASSSSGTQPAPPAPAS(ph)PWDSKK ddPTM_A459_Selumetinib_30min_R2 1 EAASSSSGTQPAPPAPASPWDSKK 24 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 EAASSSSGTQPAPPAPAS(0.999)PWDS(0.001)KK 207.42 5.961e-32 101820000.0 63224.0 58151.0 56273.0 63431.0 62890.0 47617.0 58259.0 52242.0 43462.0 60665.0 True False 59710.26318572499 62610.99471506442 52652.45644540981 54791.58837542172 54989.19595626655 54175.80952591114 60968.158938018416 52394.015570871336 52155.614429743364 58913.44382340071 1.0135252551983351 1.0627624299599174 0.8937256596854383 0.9300354014215382 0.9333896032474777 0.9195831377352319 1.034876846119825 0.8893388702233729 0.88529223628626 1.0 15.846309268685175 -5.255979339767043 24.997695176125614 0.9344981825499501 1.0381438494652717 0.4329026867458551 0.046845606942530475 402.3636850309267 1842127.553390396 0.011937031201746408 0.029764654477609606 5.54652098209098e-06 5.255979339767043 0.10364566691532162 EAATQEDPEQLPELEAHGVS(ph)ESEGEERPVAEEEILLR ddPTM_A459_Selumetinib_30min_R1 1 EAATQEDPEQLPELEAHGVSESEGEERPVAEEEILLR 37 1 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2;X6RJY0 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 EAATQEDPEQLPELEAHGVS(0.937)ES(0.063)EGEERPVAEEEILLR 83.917 4.4018e-08 45219000.0 355.64 369.06 493.94 503.14 374.72 321.24 324.38 201.68 133.85 276.23 True False 363.9257200450231 325.8502836286606 426.86566101820773 415.2760441075249 340.82664216218933 318.008617262583 299.9117554401638 196.3307912510336 227.13367398279155 311.6868112080526 1.167600639354935 1.0454413594393437 1.369533922092304 1.3323503888341492 1.0934907410461001 1.0202825587326845 0.9622215142108503 0.6298976542834267 0.7287240454687659 1.0 8.28395329947879 -7.118763249782845 1.474098039639585 0.7710247526088718 1.2170598580280685 0.654712947907302 0.1295538997162529 0.24590980553617225 1.06286583130759 0.0729712929079628 0.04883738894147051 7.607408723172616e-08 7.118763249782845 0.44603510541919666 EAAVSASDILQESAIHS(ph)PGTVEK ddPTM_A459_Selumetinib_30min_R1 3 EAAVSASDILQESAIHSPGTVEK 23 0 F5H3K2;F5H8B7;E7ENF1;G5EA44;F5H7W8;Q96C57 F5H3K2 C12orf43 Uncharacterized protein C12orf43 1 EAAVSASDILQESAIHS(0.999)PGT(0.001)VEK;EAAVSASDILQES(0.001)AIHS(0.988)PGT(0.011)VEK;EAAVSASDILQESAIHS(0.999)PGT(0.001)VEK 166.34 2.4670000000000003e-12 252770000.0 8020.66 8968.32 9640.45 9488.36 10171.16 8235.67 9572.36 8701.25 3355.93 7028.400000000001 True False 8207.525772512417 7918.304925141145 8331.329841201314 7831.396044576219 9251.180373864148 8152.8266371900645 8850.309178448753 8470.464584356681 5694.7681025705615 7930.563602413492 1.0349233905664206 0.9984542489176158 1.05053439564697 0.9874955220323693 1.166522436192146 1.028026133566211 1.1159748060976848 1.0680785135849464 0.7180786118199071 1.0 12.953207682434181 -8.234118073326906 24.943895154563002 0.8590392893408849 1.056567879328528 0.48925984579311765 0.08059728872603746 474.0307736588462 432783.5694773831 0.05093213868387959 0.01923986822913181 5.83286502348908e-09 8.234118073326906 0.1975285899876431 EAAVSASDILQESAIHS(ph)PGTVEK ddPTM_A459_Selumetinib_30min_R2 4 EAAVSASDILQESAIHSPGTVEK 23 0 F5H3K2;F5H8B7;E7ENF1;G5EA44;F5H7W8;Q96C57 F5H3K2 C12orf43 Uncharacterized protein C12orf43 1 EAAVSASDILQESAIHS(0.998)PGT(0.002)VEK;EAAVSASDILQESAIHS(0.997)PGT(0.003)VEK;EAAVSASDILQESAIHS(0.991)PGT(0.008)VEK;EAAVSASDILQESAIHS(0.999)PGT(0.001)VEK 196.37 7.103399999999998e-23 188079000.0 241024.0 238449.0 279383.0 320263.0 332519.0 235455.0 243077.0 253398.0 221300.0 285791.0 True False 227628.85097551855 256737.27156562076 261407.80194921125 276642.6269155102 290744.9904624231 267886.7890023185 254380.56214793798 254135.34622770315 265566.18363863125 277539.47125580604 0.820167488053311 0.9250477793444665 0.9418761258223831 0.9967685881354541 1.0475806887822656 0.9652205064389175 0.9165563406059721 0.9156728053051183 0.956859153896207 1.0 18.08233343845992 -4.663180111314721 1.6657642839057585 0.9671606294881656 0.7351991458384618 0.5858873420446009 0.03769356546681502 1.1127881155771777 2.416498455895532 0.011908394920168174 0.4567021266290707 2.1718002995129045e-05 4.663180111314721 -0.23196148364970381 EAAYHPEVAPDVR ddPTM_A459_Selumetinib_30min_R1 1 EAAYHPEVAPDVR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 102.9 0.012537 5669900.0 3277.7 4179.9 4956.8 4900.8 4171.4 4023.6 4503.1 3987.3 1865.2 3259.9 False True 3354.064032706031 3690.515364817209 4283.693785753436 4044.9672794096273 3794.0976065204836 3983.1262371364983 4163.427541533392 3881.543851424268 3165.1081711819415 3678.3399191149783 0.9118417836470727 1.0033100382155982 1.1645725734842112 1.0996719629932572 1.0314700897554234 1.0828597478002666 1.1318767794943563 1.0552433806493287 0.8604719087363405 1.0 11.844839091481438 -8.17717540730525 7.695889222326345 0.9309695407040808 1.0656167847985367 0.33100813849672883 0.07357598414892051 0.30076600854069907 24.129107009434943 0.051778107329991295 0.01936174716754714 6.650045131176595e-09 8.17717540730525 0.13464724409445594 EAAYHPEVAPDVR ddPTM_A459_Selumetinib_30min_R2 2 EAAYHPEVAPDVR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 ; 110.92 0.0076257999999999986 10664000.0 75171.0 76783.0 84355.0 85948.0 81111.0 59281.0 62341.0 63190.0 56531.0 79822.0 False True 70993.29675335529 82672.00920374176 78927.69113877947 74241.73413143023 70921.11103845974 67446.41965066132 65239.98002634798 63373.872438332335 67838.77960811327 77517.33145753718 0.9158377283955439 1.0664971000585624 1.018194120653068 0.9577436779038083 0.9149065080666413 0.8700818047072151 0.8416179814198771 0.8175445574135584 0.8751433819064621 1.0 16.24223128622552 -6.2806893899010845 1.8343745037164356 0.8674140754335496 1.0054925557793535 0.4394901859410064 0.0577567736945169 0.27531638261197683 1.825015571615523 0.019702462887417664 0.02561465638533108 5.239750528036268e-07 6.2806893899010845 0.13807848034580383 EADDDEEVDDNIPEMPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EADDDEEVDDNIPEMPSPK 19 0 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 EADDDEEVDDNIPEMPS(1)PK;EADDDEEVDDNIPEMPS(1)PK 142.32 6.0452e-05 78749000.0 5550.0 8917.2 9141.6 10070.3 6199.2 8163.400000000001 6488.9 6434.9 4315.4 6191.8 True False 5679.304201579908 7873.170078506194 7900.220931214409 8311.711147942933 5638.483454557654 8081.2836077741595 5999.437048756635 6264.225548498992 7322.9186156543765 6986.577843239407 0.8128878442362897 1.1268993569039958 1.1307711884809373 1.189668437743923 0.8070451057829059 1.1566869773867974 0.858708967876457 0.8966085670340876 1.0481409897608787 1.0 12.77037025420567 -6.249279809875647 24.97133993892234 0.9606788101847883 1.0741679165449056 0.12849771410963995 0.13164852938546504 1511.920052994616 3104933.3707974493 0.038330648095923105 0.04909140216575894 5.632746289070228e-07 6.249279809875647 0.11348910636011733 EADDDEEVDDNIPEMPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 EADDDEEVDDNIPEMPSPK 19 0 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 EADDDEEVDDNIPEMPS(1)PK;EADDDEEVDDNIPEMPS(1)PK 175.77 6.133800000000002e-13 19129000.0 125493.0 125015.0 129454.0 110512.0 103555.0 88807.0 110430.0 111500.0 71327.0 115623.0 True False 118518.60144828203 134603.24851341805 121125.07057885834 95460.07495616666 90545.49510655405 101039.3581403195 115565.21381289384 111824.44654018132 85594.39304289501 112284.6635653683 1.0555190502867253 1.1987678836928306 1.0787320969113778 0.8501612947398917 0.8063923623357659 0.899850032337656 1.029216369745951 0.9959013367402658 0.7622981654397074 1.0 16.776801364694037 -5.644816400353701 5.180127234104902 0.9073230272286468 1.1292863938130953 0.5378887495952602 0.08750126152864147 0.15857435331668293 6.501813369990456 0.024868582060720845 0.043835268680049735 2.265601896997348e-06 5.644816400353701 0.22196336658444848 EADDDEEVDDNIPEMPS(ph)PKK ddPTM_A459_Selumetinib_30min_R1 4 EADDDEEVDDNIPEMPSPKK 20 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 EADDDEEVDDNIPEMPS(1)PKK;EADDDEEVDDNIPEMPS(1)PKK;EADDDEEVDDNIPEMPS(1)PKK;EADDDEEVDDNIPEMPS(1)PKK 191.4 7.8104e-16 41304000.0 5277.17 7160.53 10840.53 12957.4 6106.580000000001 8114.429999999999 5497.95 5062.849999999999 3536.3599999999997 4340.48 True False 5400.117793414674 6322.171818759916 9368.445568768902 10694.633330522012 5554.2409172042635 8032.806201512953 5083.235205075059 4928.566771545492 6000.944634484758 4897.622887855515 1.1025997544247803 1.2908653776583763 1.9128556410497732 2.183637567735394 1.1340687195367662 1.6401438790707337 1.0378984502215964 1.006318143392932 1.2252769908775778 1.0 12.257865976741575 -7.265044162601138 24.78767349056042 1.0678998777153825 1.5597245578967074 0.3484252902421219 0.31889463597186113 349.18034338133293 2401061.7794788936 0.1391782949913176 0.09801494253851196 5.4319509218147914e-08 7.265044162601138 0.49182468018132486 EADDDEEVDDNIPEMPS(ph)PKK ddPTM_A459_Selumetinib_30min_R2 2 EADDDEEVDDNIPEMPSPKK 20 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 EADDDEEVDDNIPEMPS(1)PKK;EADDDEEVDDNIPEMPS(1)PKK 166.77 1.6758e-09 13956400.0 75395.0 99556.0 78690.0 64699.0 61124.0 46939.0 30827.0 33481.0 18500.5 71072.0 True False 71204.84773009825 107191.6250770055 73627.17107119397 55886.88458799969 53445.056664506854 53404.42118018234 32260.516582541648 33578.42416692208 22201.11694715999 69019.96669276725 1.0316557822616272 1.5530524022730128 1.0667517618334277 0.809720538359173 0.7743419654548671 0.7737532157600809 0.46740846349788656 0.4865030479714913 0.3216622379142135 1.0 16.07472615711611 -5.949449788032081 1.0143589941932474 0.5590135122341433 1.3267656699183297 0.5914115233618307 0.21798264496936998 0.36940131522352454 0.7636672143362525 0.08796288121912196 0.20005894052546258 1.1234408513962168e-06 5.949449788032081 0.7677521576841864 EADLVFIS(ph)VNTPTK ddPTM_A459_Selumetinib_30min_R1 1 EADLVFISVNTPTK 14 0 O60701;E7ER83;E7ETF4;E7EV97 O60701 UGDH UDP-glucose 6-dehydrogenase 1 EADLVFIS(0.923)VNT(0.077)PTK 151.44 0.00040176 15580000.0 9030.3 9858.7 8475.1 9362.7 9192.5 8495.3 9357.6 9218.2 4875.7 8147.4 True False 9240.68842009496 8704.438820814712 7324.227970391971 7727.6802046458715 8361.039998067694 8409.844995115242 8651.748698153018 8973.703391066429 8273.706792961499 9193.198152396515 1.005165804860419 0.9468346789137367 0.7967007616911495 0.8405867116691478 0.9094811032532905 0.9147899192103168 0.9411032542464725 0.9761242216591548 0.8999813400959578 1.0 13.166351121796826 -7.130990911844804 2.022139491509928 0.9541709411266807 0.8935132372810699 0.1669096918582298 0.05767003353286633 0.6602216983992012 5.310379387383776 0.029486491123329052 0.02081015484672791 7.396207523855667e-08 7.130990911844804 -0.060657703845610755 EADLVFIS(ph)VNTPTK ddPTM_A459_Selumetinib_30min_R2 1 EADLVFISVNTPTK 14 0 O60701;E7ER83;E7ETF4;E7EV97 O60701 UGDH UDP-glucose 6-dehydrogenase 1 EADLVFIS(0.639)VNT(0.278)PT(0.083)K 178.01 7.1033e-05 23606000.0 73574.0 62975.0 64832.0 75543.0 76550.0 53716.0 64851.0 74083.0 53859.0 55309.0 True False 69485.05162005771 67804.98000345968 60660.77970374438 65253.9130810563 66933.10463431715 61114.891414701546 67866.69999981858 74298.56926489915 64632.30494619546 53712.08545995997 1.2936576754565936 1.2623784651594911 1.1293692878293538 1.214883252479561 1.246146077947632 1.1378238415311588 1.263527554714111 1.3832747067749867 1.2033102865532197 1.0 15.712959117135485 -5.014144246284984 23.212740918696174 1.212413603962337 1.285837981918754 0.09052698843591833 0.09522272818290956 629.9617095610653 1033890.3725931081 0.023782181131877814 0.0694729259197975 9.679563064904057e-06 5.014144246284984 0.07342437795641699 EADLVFISVNT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 EADLVFISVNTPTK 14 0 O60701;E7ER83;E7ETF4;E7EV97 O60701 UGDH UDP-glucose 6-dehydrogenase 1 EADLVFIS(0.005)VNT(0.85)PT(0.146)K;EADLVFIS(0.066)VNT(0.76)PT(0.173)K 235.26 9.3979e-14 71557000.0 9933.8 12061.900000000001 9715.400000000001 10524.2 10758.5 9305.5 11525.3 10742.2 5698.7 9562.2 True False 10165.23821219 10649.687140574819 8396.102042872199 8686.346033701191 9785.395574567447 9211.89511871799 10655.937341927729 10457.28196041676 9670.277683419754 10789.601513715526 0.9421328673972019 0.9870324800259906 0.7781660918801534 0.8050664357399373 0.9069283570971964 0.8537752860481467 0.9876117601175645 0.9692000160639549 0.8962590204213835 1.0 13.397353963114725 -7.259952887806423 24.98835535198826 0.9607010350317536 0.8771135408464609 0.30312021469154504 0.0626244924817768 191.41880948861007 3217841.6925580692 0.026782924668481936 0.019588352539593124 5.49600491194323e-08 7.259952887806423 -0.08358749418529277 EADLVFISVNTPT(ph)K ddPTM_A459_Selumetinib_30min_R2 2 EADLVFISVNTPTK 14 0 O60701;E7ER83;E7ETF4;E7EV97 O60701 UGDH UDP-glucose 6-dehydrogenase 1 EADLVFIS(0.01)VNT(0.326)PT(0.665)K;EADLVFIS(0.247)VNT(0.047)PT(0.706)K 166.9 2.1121e-06 0.0 20112.2 20495.8 19269.4 22019.6 21452.2 14600.5 18323.4 19328.9 15201.7 16118.8 True False 18994.444439515653 22067.761955615842 18029.627782936404 19020.4924940713 18757.182850898724 16611.5863448572 19175.474407128288 19385.14389892835 18242.464770986844 15653.408362328046 1.2134382493481894 1.4097736061575425 1.1518020462768377 1.2151022993718466 1.1982810654860518 1.0612120990106624 1.2250031407394029 1.2383976352128656 1.165398892607293 1.0 13.934189202333702 -14.52287872980055 0.05253591861353044 0.25009893318248044 1.5733334896890894 0.4208890896139593 0.07901883653332538 531.8819111483833 2.0526594130507765 55.60528108210547 11.488895691896756 3.000000106930591e-15 14.52287872980055 1.323234556506609 EADPES(ph)EADR ddPTM_A459_Selumetinib_30min_R2 1 EADPESEADR 10 0 F8W785;O00461 F8W785 GOLIM4 Golgi integral membrane protein 4 1 EADPES(1)EADR 117.86 0.005892199999999999 1524400.0 14277.0 4390.4 10299.0 9151.7 7082.4 7230.3 12817.0 13326.0 9021.1 7257.1 True False 13483.541495359284 4727.129562638968 9636.373552703346 7905.222672436932 6192.64559454066 8226.208194871484 13413.01589640368 13364.776453761942 10825.572070594035 7047.568666789767 1.9132188890755657 0.6707461517777903 1.3673330489297386 1.121695019402746 0.8786924806738303 1.167240588039364 1.9032118068760064 1.896366972164561 1.536071882719971 1.0 12.782909914180658 -7.239212725181117 22.023589079791478 1.6586097852549209 1.1543290624854785 0.1896871037436192 0.38697353879135 220.6260861343022 218610.12550187632 0.14009679237220707 0.10836014773405749 5.7648402207223464e-08 7.239212725181117 -0.5042807227694424 EADQPTTEPGMVLDSVEAGDT(ph)TPPTKR ddPTM_A459_Selumetinib_30min_R1 2 EADQPTTEPGMVLDSVEAGDTTPPTKR 27 1 A0A0J9YVR0;A0A0J9YWV8 A0A0J9YVR0 1 EADQPTTEPGMVLDS(0.003)VEAGDT(0.79)T(0.162)PPT(0.045)KR;EADQPTTEPGMVLDS(0.012)VEAGDT(0.922)T(0.06)PPT(0.006)KR 105.08 3.0621e-09 31220000.0 4567.3 5131.8 5414.9 4984.3 4950.5 4616.1 4912.6 4604.700000000001 2798.1000000000004 4627.4 True False 4673.709203581249 4530.966470290904 4679.586321916611 4113.88557189875 4502.72814908176 4569.666225083455 4542.038626843052 4482.568397826433 4748.171334861778 5221.371864692983 0.8951113471126163 0.867773180632735 0.8962369360359227 0.7878936184792589 0.8623649618846907 0.8751849788718605 0.8698937261213676 0.8585039552799614 0.9093723752887635 1.0 12.35021319535784 -8.645838638208744 2.264436524368256 0.9999436513668276 0.8630932790545626 0.6801285611423302 0.028411929380914646 0.2866963103585302 3.0873474939877554 0.027761792832490834 0.007590471061390585 2.2602754178739765e-09 8.645838638208744 -0.13685037231226505 EADQPTTEPGMVLDSVEAGDT(ph)TPPTKR ddPTM_A459_Selumetinib_30min_R2 1 EADQPTTEPGMVLDSVEAGDTTPPTKR 27 1 A0A0J9YVR0;A0A0J9YWV8 A0A0J9YVR0 1 EADQPTTEPGMVLDS(0.161)VEAGDT(0.724)T(0.087)PPT(0.028)KR 80.171 0.00012964 3190400.0 40655.0 39114.0 46385.0 44587.0 45243.0 33648.0 33234.0 39608.0 25012.0 39590.0 True False 38395.55785485971 42113.918028667234 43400.63960016946 38514.17368313489 39559.16986244817 38282.70657386768 34779.44685192167 39723.25272254262 30015.098893671286 38446.93383282674 0.9986637171590739 1.0953778059853905 1.1288452751234261 1.0017489002010023 1.0289291217462908 0.9957284692799394 0.9046091166371842 1.0331968966697191 0.7806890147386424 1.0 15.230580926486592 -6.812407104125082 1.0291141100425036 0.9241616481422288 1.0698174145508668 0.3891598593119875 0.07195175178876746 0.5171551601689819 1.1663704517284366 0.039712535715731447 0.034254598811994684 1.540255952585838e-07 6.812407104125082 0.14565576640863798 EAEAAIYHLQLFEELRR ddPTM_A459_Selumetinib_30min_R1 2 EAEAAIYHLQLFEELRR 17 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 139.64 0.00034139 61014000.0 8708.5 9189.2 8901.5 8512.400000000001 8084.9 6653.6 6350.2 6709.8 5018.8 5056.5 False True 8911.391106208765 8113.324192056816 7692.725192439511 7025.869137538056 7353.622222505029 6586.670824985436 5871.199301424646 6531.834307497946 8516.537041351023 5705.551029480933 1.5618808876063082 1.422005368129173 1.3482878608377573 1.2314093943310573 1.2888539922802216 1.154432024348166 1.0290328262928152 1.1448209425781237 1.4926756412037248 1.0 12.478150510196235 -4.905916922488108 0.6883352416395224 1.1702951161050934 1.7580985759842538 0.4966781779186743 0.1280513078589708 2.3881814766217095 0.9597110212145418 0.058301769186693365 1.0706612014638475 1.2418898497568648e-05 4.905916922488108 0.5878034598791604 EAEALLQSMGLTPESPIVPPPMS(ph)PSSK ddPTM_A459_Selumetinib_30min_R1 2 EAEALLQSMGLTPESPIVPPPMSPSSK 27 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 EAEALLQSMGLTPESPIVPPPMS(0.796)PS(0.15)S(0.054)K;EAEALLQSMGLTPESPIVPPPMS(0.764)PS(0.086)S(0.15)K 183.04 1.0304999999999999e-26 119479000.0 7568.200000000001 9317.900000000001 9846.1 9607.3 8877.0 8197.2 8047.0 8344.0 4387.0 7415.299999999999 True False 7744.524334846316 8226.955936225813 8509.05370075591 7929.565406356527 8074.076917361642 8114.743610462103 7440.008311323129 8122.690014868229 7444.418586197285 8367.125986138626 0.9255895450452473 0.9832475272698146 1.016962540644471 0.9477047936762297 0.9649761376531842 0.9698364317574958 0.8891952055757971 0.9707861490701417 0.8897223011258655 1.0 13.030516442972727 -7.094589693679571 24.99896439911331 0.9342089436416631 0.9699158010981527 0.13080891531516214 0.03813834718332054 95.64055045163921 25269.54874563352 0.013843153137923217 0.010722861054884087 8.042856244359555e-08 7.094589693679571 0.035706857456489605 EAEALLQSMGLTPESPIVPPPMS(ph)PSSK ddPTM_A459_Selumetinib_30min_R2 3 EAEALLQSMGLTPESPIVPPPMSPSSK 27 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 EAEALLQSMGLTPES(0.021)PIVPPPMS(0.739)PS(0.12)S(0.12)K;EAEALLQSMGLTPESPIVPPPMS(0.682)PS(0.159)S(0.159)K;EAEALLQSMGLTPES(0.005)PIVPPPMS(0.723)PS(0.136)S(0.136)K 75.88 0.00026173 9007000.0 48772.0 47882.0 60828.0 60204.0 57415.0 42630.0 47288.0 47495.0 41509.0 56478.0 True False 46061.44748978518 51554.395435103674 56914.39270451883 52004.11134230721 50202.014403387555 48501.89554338981 49486.98569939436 47633.202586779465 49811.95985836404 54847.33339253314 0.8398119770040806 0.9399617492091646 1.0376875079266314 0.9481611616397562 0.9153045608270539 0.8843072678897604 0.9022678522075873 0.8684688870081732 0.908192919824711 1.0 15.743133859888264 -6.352271248816832 4.272069216343007 0.9036047163723712 0.9481039474274804 0.04091086914836961 0.05547048156157907 0.5273158593035291 17.135532727013505 0.017950936726662516 0.02061651264622455 4.443536492756274e-07 6.352271248816832 0.04449923105510922 EAEAYTGLS(ph)PPVPSFNCEVR ddPTM_A459_Selumetinib_30min_R1 1 EAEAYTGLSPPVPSFNCEVR 20 0 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 1 EAEAYT(0.169)GLS(0.798)PPVPS(0.033)FNCEVR 175.8 4.7642e-13 4864200.0 634.08 658.7 454.5 532.68 710.99 589.0 706.13 729.08 385.8 704.27 True False 648.8528302950972 581.5790977786778 392.7813963897951 439.65743764200107 646.6810800354799 583.0751947692108 652.8660455914752 709.7424300143972 654.6744222828615 794.6699146707283 0.8165060968288318 0.7318499002439967 0.49426987122388316 0.5532579370695986 0.8137732007929763 0.7337325649364846 0.8215562632215546 0.8931286020919506 0.8238318957300983 1.0 9.634211916389214 -7.3890853100990315 0.8064640788687026 0.9372657336200662 0.6557182225692485 0.5154220805306726 0.09928818221190568 0.5734844719947881 0.7107813225142632 0.09046640521764508 0.049926420961268314 4.0823918649664565e-08 7.3890853100990315 -0.28154751105081766 EAEAYTGLS(ph)PPVPSFNCEVR ddPTM_A459_Selumetinib_30min_R2 1 EAEAYTGLSPPVPSFNCEVR 20 0 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 1 EAEAY(0.001)T(0.019)GLS(0.888)PPVPS(0.092)FNCEVR 142.72 4.7712e-05 3481900.0 14269.0 8440.4 9856.6 12705.0 14439.0 11657.0 15710.0 15481.0 14106.0 10667.0 True False 13475.98610333275 9087.751539836456 9222.437087054657 10974.557082652542 12625.043733702221 13262.645938289814 16440.546128774437 15526.047146982492 16927.594154570896 10359.015993805579 1.3008944200289911 0.8772794197123254 0.8902811900830575 1.0594208068811788 1.2187493234156284 1.2802997839003754 1.5870760445398922 1.4987955570554832 1.6340928679609295 1.0 13.338599347025665 -6.665962833179767 1.66928759198637 1.465837713235337 1.0096385009529332 0.43193431057218157 0.1983145800046564 0.2975804921854809 1.7121602255988022 0.07902209463024218 0.07752047469891563 2.1579290763165416e-07 6.665962833179767 -0.4561992122824039 EAEDSLRR ddPTM_A459_Selumetinib_30min_R2 2 EAEDSLRR 8 1 O43776;K7EMQ6;K7EJ19;K7EIU7;K7EPK2;O43776-2 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 ; 128.61 0.0057988 21744000.0 114541.0 112641.0 112611.0 116728.0 145485.0 90048.0 97537.0 105572.0 93270.0 117633.0 False True 108175.26976395243 121280.20250209891 105365.7308615865 100829.44503296872 127207.8736475979 102451.2946256431 102072.6637658988 105879.19704161446 111926.60618154155 114236.6296427611 0.9469403124219994 1.0616577439422394 0.922346284121691 0.8826367282392775 1.113547152479903 0.8968340097745102 0.893519566229315 0.9268410436540201 0.9797786098168038 1.0 16.80166579528374 EAEEGEDDRDS(ph)ANGEDDS ddPTM_A459_Selumetinib_30min_R1 1 EAEEGEDDRDSANGEDDS 18 1 G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;G3V2D6;P07910-3 G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 EAEEGEDDRDS(0.999)ANGEDDS(0.001) 159.18 7.719399999999999e-05 15340000.0 983.27 784.08 509.83 285.41 767.22 525.67 891.64 1317.3 721.21 1193.8 True False 1006.178277889635 692.2795490910977 440.59788629572944 235.56850130923536 697.8250864636929 520.3822370701716 824.3828769365178 1282.3609248065584 1223.8406949057096 1347.0358585967253 0.7469573073858785 0.513928077469504 0.32708697655214786 0.17487916138671977 0.5180449221230474 0.3863165436533218 0.6119977220170804 0.9519872218861775 0.9085435158204664 1.0 10.39557254105331 -7.629929071482035 2.8263451657807024 0.957469300919224 0.43424432916437156 0.7218958904983155 0.14090139061755239 0.15101018962909757 2.4181567000837254 0.08477066863962014 0.04322452959535487 2.3446117035698278e-08 7.629929071482035 -0.5232249717548525 EAEEGEDDRDS(ph)ANGEDDS ddPTM_A459_Selumetinib_30min_R2 2 EAEEGEDDRDSANGEDDS 18 1 G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;G3V2D6;P07910-3 G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 EAEEGEDDRDS(0.913)ANGEDDS(0.087);EAEEGEDDRDS(0.649)ANGEDDS(0.351) 93.115 0.02248 19270700.0 23329.0 10689.7 19061.0 23698.0 26704.0 24720.0 39971.0 37250.0 38508.0 15094.8 True False 22032.467573386344 11509.565617197017 17834.636012047635 20470.29151866979 23349.204783211026 28124.95561418238 41829.730701033935 37358.39133293054 46210.67600341813 14658.97390299957 1.5030020326919324 0.7851549292165592 1.2166360435636119 1.3964341333932717 1.592826683348773 1.9186169373306103 2.853523785349982 2.548499750401093 3.1523813541930337 1.0 13.839496500970473 -6.775807623544938 1.698764494905789 2.513574937897751 1.191224527205288 0.4503332266923159 0.5654701638488256 0.283372690295571 1.692707757607922 0.2296067183978135 0.2070079470325091 1.67568497836158e-07 6.775807623544938 -1.3223504106924633 EAEEGEDDRDSANGEDDS ddPTM_A459_Selumetinib_30min_R1 1 EAEEGEDDRDSANGEDDS 18 1 G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;G3V2D6;P07910-3 G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 127.71 0.014303 0.0 209.27 0.0 0.0 0.0 184.23 79.048 164.19 73.098 160.15 150.59 False True 214.14558383146445 0.0 0.0 0.0 167.5664290284483 78.2528488898414 151.8050161098726 71.15920358423273 271.7628531067918 169.91969337081656 1.2602752487560904 0.0 0.0 0.0 0.9861507262890787 0.46052842573738545 0.8933927145136015 0.41878137944223837 1.599360543299254 1.0 7.408709257611341 -7.523250944876359 0.7907224638059315 1.1586994008482652 0.34062474108894863 0.2685993078647977 0.46244506028507304 0.8696835058684644 1.020764221940507 0.4031835262203608 0.20677046936774954 2.9974300376891906e-08 7.523250944876359 -0.8180746597593165 EAEEGEDDRDSANGEDDS ddPTM_A459_Selumetinib_30min_R2 1 EAEEGEDDRDSANGEDDS 18 1 G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;G3V2D6;P07910-3 G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 116.51 0.027085 0.0 3595.9 1323.6 3282.1 4835.1 2697.6 5228.8 5423.7 6538.3 6023.9 2558.9 False True 3396.054273528226 1425.1158639552073 3070.9332592802853 4176.5510389872725 2358.703371150016 5949.019737679487 5675.912796857661 6557.325370526166 7228.848321828979 2485.0179081793476 1.3666115895383428 0.5734831363848483 1.2357791262479108 1.6806925315267565 0.9491695667006779 2.3939544733655644 2.2840530759056494 2.63874370842277 2.908972324921878 1.0 11.279040533209585 -6.76639520201901 24.999713241225475 2.3499981799023746 1.1615089829341736 0.4957056372363712 0.541534832768484 95.32103255238337 480844.9286906246 0.18173753413212956 0.16526170754979994 1.712398339305456e-07 6.76639520201901 -1.188489196968201 EAEEGEDDRDSANGEDDS(ph) ddPTM_A459_Selumetinib_30min_R2 1 EAEEGEDDRDSANGEDDS 18 1 G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;G3V2D6;P07910-3 G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 EAEEGEDDRDS(0.438)ANGEDDS(0.562) 93.215 0.046373 0.0 3577.3 1190.6 2594.0 4283.3 3802.1 2455.0 6382.7 4928.8 4416.1 2045.3 True False 3378.4879870665263 1281.9151916176102 2427.1048641336533 3699.9071508953634 3324.4462067947343 2793.1539657288754 6679.508197080112 4943.141991993235 5299.443396143522 1986.2468746724041 1.7009406182822804 0.6453956997812968 1.2219552841506476 1.8627629818199698 1.6737326307149216 1.4062471293703387 3.3628791477302022 2.488684591540776 2.6680688406457884 1.0 10.955829234180163 -7.221596392784257 22.925340845374517 2.5039650112577982 1.4062241591090663 0.3498430235703578 0.6329667664177571 190.86696912203243 109823.13327266618 0.2349071508516481 0.1819549324193833 6.003487451612247e-08 7.221596392784257 -1.097740852148732 EAEEGPTGASESQDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 EAEEGPTGASESQDSPR 17 0 H0Y507;Q5TCZ1-2;Q5TCZ1-3;Q5TCZ1 H0Y507 SH3PXD2A SH3 and PX domain-containing protein 2A 1 EAEEGPTGASES(0.001)QDS(0.998)PR 218.36 1.2865999999999998e-39 0.0 6728.7 3945.1 5851.6 6485.7 4717.5 2551.6 4853.5 4704.2 3366.2 4295.7 True False 6354.745791120264 4247.676484504146 5475.114426740354 5602.336471543448 4124.845475014905 2903.059738881384 5079.1973670278 4717.888443177765 4039.5340594864983 4171.671979431012 1.5233090766611541 1.018219194952979 1.3124508479420578 1.3429475038225727 0.9887751231048386 0.6958983719705933 1.2175447619255455 1.130934662753914 0.9683249496614218 1.0 12.026410007176286 -6.267739037746021 24.679286650317337 1.002440557222558 1.2801035679470558 0.4228149279803737 0.17053835462973677 466.21881830572164 1826437.524385546 0.0533782870393174 0.06203909291315514 5.398349052829476e-07 6.267739037746021 0.2776630107244977 EAEFGQGTGPIWLNEVK ddPTM_A459_Selumetinib_30min_R1 1 EAEFGQGTGPIWLNEVK 17 0 H0YGZ7;F5GZZ9;C9JHR8;Q86VB7-3;Q86VB7-4;Q86VB7;Q86VB7-2 H0YGZ7 CD163 Scavenger receptor cysteine-rich type 1 protein M130;Soluble CD163 0 60.549 0.033579000000000005 18367000.0 6733.4 6867.6 6932.0 6148.9 5775.2 4701.1 4701.0 4453.2 3163.0 3701.6 False True 6890.275119084351 6063.538199339374 5990.672474750405 5075.110044148272 5252.834179694376 4653.8112022572805 4346.399785203186 4335.086669967782 5367.379983620248 4176.736416637321 1.6496791829233248 1.4517406880612094 1.4342950756690265 1.2150898543495425 1.257640812278841 1.11422190390555 1.040621037968793 1.0379124362982781 1.2850655268166313 1.0 12.028160386168802 -5.128360473792616 0.5629214322127285 1.0775109923071153 1.8687646410522119 0.8288470744664483 0.08342638494893422 1.0995144793323985 0.3487113829467173 0.04833440043130771 0.5406912180909533 7.441140867606755e-06 5.128360473792616 0.7912536487450965 EAEFS(ph)DPENTR ddPTM_A459_Selumetinib_30min_R1 1 EAEFSDPENTR 11 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 EAEFS(0.995)DPENT(0.005)R 128.36 0.0027907 28456000.0 3529.9 3917.9 3857.3 3937.4 3979.4 3443.8 3852.3 3421.7 1912.9 3095.0 True False 3612.139802010258 3459.190446617705 3333.499846632245 3249.807004151865 3619.4639726201344 3409.1584987202177 3561.7179094954763 3330.9454007519926 3246.051587311781 3492.2733978529604 1.0343233162188823 0.9905268152099448 0.9545357613415006 0.9305706151614123 1.0364205662836623 0.9762003458309302 1.0198851875930477 0.9538043048977346 0.929495264977663 1.0 11.769950791592496 -7.8070319870696085 24.996620432461874 0.9562372348391052 0.9890631878044979 0.12775739275339282 0.035578855525889096 265.06336017602877 145320.13733746993 0.019677486926477663 0.009452821540956273 1.5594376414149806e-08 7.8070319870696085 0.0328259529653927 EAEFS(ph)DPENTR ddPTM_A459_Selumetinib_30min_R2 1 EAEFSDPENTR 11 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 EAEFS(1)DPENTR 122.46 0.0041455 30820000.0 58330.0 55652.0 71985.0 73520.0 78478.0 47666.0 50406.0 59944.0 52184.0 61943.0 True False 55088.252113490744 59920.32945061589 67353.56347134207 63506.449170925895 68618.89203777841 54231.55883113343 52749.97887759417 60118.42711573662 62622.258142785104 60154.54464275796 0.9157787236300333 0.9961064422724333 1.1196753939596285 1.0557215510162037 1.1407100235782348 0.9015371848162165 0.8769076250325298 0.9993995877246543 1.0410228938591797 1.0 15.876386115885 -6.7765030296282145 24.987904286310183 0.9583068317571541 1.0475266778864893 0.23455651613704465 0.07353559181931786 365.5063352328586 606305.9467482211 0.02774902847030063 0.02457047808994977 1.6730039655211474e-07 6.7765030296282145 0.0892198461293352 EAEGGRPPAAT(ph)SPAEVVWSSEK ddPTM_A459_Selumetinib_30min_R1 2 EAEGGRPPAATSPAEVVWSSEK 22 1 O75564;O75564-2 O75564 JRK Jerky protein homolog 1 EAEGGRPPAAT(0.877)S(0.122)PAEVVWS(0.001)SEK;EAEGGRPPAAT(0.753)S(0.247)PAEVVWSSEK 63.893 0.011012 10900500.0 2726.2 3048.5 2963.1 3606.2 3040.0 2433.8999999999996 3383.2 2690.1 1212.68 2418.8 True False 2789.715155738223 2691.580202790799 2560.7272951432383 2976.444866757873 2765.0325367555906 2409.417175804386 3128.0025001700546 2618.749809323708 2057.82938935713 2729.2765411071846 1.0221445550572608 0.9861881572832142 0.9382439839183276 1.0905618474082586 1.0131009060862337 0.8828043400933488 1.1460921797617178 0.9595032859005782 0.7539834671800356 1.0 11.414302866255058 -8.010250605715612 24.924049544402852 0.8702422570976658 1.0090679496769863 0.2681238450826168 0.08799963269842585 545.4311102468553 1326192.90431814 0.049891926613067746 0.02160090454613065 9.766734776943903e-09 8.010250605715612 0.13882569257932054 EAEHLSSPWGESS(ph)PEELR ddPTM_A459_Selumetinib_30min_R2 1 EAEHLSSPWGESSPEELR 18 0 Q6PJI9-3;Q6PJI9;Q6PJI9-4;H3BNY4 Q6PJI9-3 WDR59 WD repeat-containing protein 59 1 EAEHLSSPWGES(0.012)S(0.988)PEELR 179.85 9.7594e-10 2262500.0 5203.6 5135.2 12297.0 15912.0 20859.0 10623.0 6361.7 9738.9 10150.0 13211.0 True False 4914.404743661247 5529.053327729509 11505.824407961272 13744.75815026896 18238.50593817401 12086.221824007263 6657.531655469402 9767.238586638316 12180.283614695492 12829.564103699771 0.38305313445871775 0.4309619004230275 0.8968211480110411 1.071334773276145 1.4215998135832546 0.942060207682493 0.518921110776438 0.7613071268587881 0.9493918512151913 1.0 13.647184533912064 -5.266140638947241 4.352343959048446 0.9459904812118444 0.3937188182744671 0.5026845619373328 0.21486483085163535 0.1793038353480967 8.847002101360697 0.06483921279441399 0.16354985013723952 5.418254009657348e-06 5.266140638947241 -0.5522716629373773 EAENPEGEEK ddPTM_A459_Selumetinib_30min_R2 1 EAENPEGEEK 10 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 134.23 0.029602 2987000.0 21138.0 14116.0 22728.0 26616.0 23819.0 19570.0 22461.0 25022.0 21606.0 23734.0 False True 19963.234582118414 15198.651809906083 21265.705224375353 22990.85488483902 20826.64427543826 22265.589861227716 23505.48100562716 25094.80987738489 25927.803722079883 23048.73775166228 0.8661313603031758 0.6594136292261797 0.9226407733691042 0.9974886751957128 0.9035915328567716 0.9660220920176819 1.0198164107243548 1.0887715478291233 1.1249120885246726 1.0 14.492400124161534 -5.78988345773271 0.5388307644886273 1.071991250300153 0.7087905224839749 0.6190296514587691 0.0765652872400795 1.0606474069366412 0.4883847338821415 0.055029267661972754 0.21597441608868 1.622245366044585e-06 5.78988345773271 -0.36320072781617807 EAENQGLDIS(ph)SPGMSGHR ddPTM_A459_Selumetinib_30min_R2 2 EAENQGLDISSPGMSGHR 18 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 1 EAENQGLDIS(0.932)S(0.068)PGMSGHR;EAENQGLDIS(0.95)S(0.05)PGMSGHR 144.4 0.00018861 49815000.0 104343.0 83602.0 132321.0 149879.0 171120.0 118782.0 111195.0 118972.0 133796.0 132872.0 True False 98544.03377812386 90014.00457720089 123807.61092021162 129465.22164430367 149622.37576779007 135143.14230436127 116365.78782871256 119318.18882312517 160558.93857259056 129035.6401170837 0.7636962446089117 0.6975902509998357 0.9594838356896722 1.0033291695753992 1.1595430195256635 1.047331901339318 0.9018112183821863 0.9246917263700077 1.244299159727525 1.0 16.977410072787855 -5.390076834858402 3.131362584748733 1.034955649234883 0.7278055622368673 0.608570924633138 0.09747564552965017 0.17320341901992733 3.169333624128754 0.027325216627494597 0.0661868823142829 4.073082109495706e-06 5.390076834858402 -0.3071500869980157 EAENQGLDISS(ph)PGMSGHR ddPTM_A459_Selumetinib_30min_R1 4 EAENQGLDISSPGMSGHR 18 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 1 EAENQGLDIS(0.036)S(0.964)PGMSGHR;EAENQGLDIS(0.013)S(0.987)PGMSGHR;EAENQGLDIS(0.189)S(0.81)PGMS(0.001)GHR;EAENQGLDIS(0.23)S(0.77)PGMSGHR 218.95 1.7789e-14 30328900.0 11323.2 13404.199999999999 9257.5 9448.0 13484.900000000001 9912.9 14090.2 11681.300000000001 4224.09 9249.5 True False 11587.008528888224 11834.830032556478 8000.382347807536 7798.084160925182 12265.19317595246 9813.185226193063 13027.364869914898 11371.473977790052 7167.972214672916 10436.763422759599 1.1102109015540458 1.133955954845934 0.7665577941875148 0.7471745640913723 1.1751912618049363 0.9402517647179115 1.2482188531270084 1.0895594273021574 0.686800296636179 1.0 13.349386762158444 -6.283975192270858 24.97848777434384 1.0349047178675077 0.9410150297954571 0.04597588225152016 0.182589021859038 2779.8421713881703 3081141.9278054163 0.05932430469150906 0.0673178312045461 5.200257005450004e-07 6.283975192270858 -0.09388968807205056 EAETKSPLVS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 EAETKSPLVSPSK 13 1 P35612 P35612 ADD2 Beta-adducin 1 EAETKS(0.002)PLVS(0.998)PSK;EAET(0.001)KS(0.026)PLVS(0.944)PS(0.029)K 175.6 0.00046962 17491900.0 4929.9 5295.2 5641.6 5804.9 4778.0 5277.6 4781.4 4953.700000000001 3016.7 4840.4 True False 5044.75707808447 4675.235522328307 4875.501707090579 4791.183186468519 4345.830743624417 5224.512135677398 4420.735148472772 4822.311784114662 5119.119568949478 5461.712489488681 0.9236584839999064 0.8560017634260343 0.8926690514144983 0.8772309409712381 0.7956901341819382 0.9565703331569015 0.8094045882094091 0.8829303617492544 0.9372737175018753 1.0 12.415137655721312 -8.484448531190239 2.476489601829892 0.9989151232013419 0.872065898608168 0.4428725184939446 0.04513559452823416 0.23331363942773917 3.2262594549540853 0.04062949554784469 0.011080705871788074 3.2775661737103612e-09 8.484448531190239 -0.12684922459317394 EAFAQRPS(ph)SAPDLMCLSPDR ddPTM_A459_Selumetinib_30min_R2 2 EAFAQRPSSAPDLMCLSPDR 20 1 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 EAFAQRPS(0.978)S(0.018)APDLMCLS(0.004)PDR;EAFAQRPS(0.809)S(0.178)APDLMCLS(0.013)PDR 86.617 0.0012345 15748300.0 15401.099999999999 10557.099999999999 13097.900000000001 17861.5 17070.1 14555.7 9746.1 12915.7 9612.5 13960.6 True False 14545.168517488124 11366.795623573213 12255.195373915252 15428.732887193883 14925.601429369777 16560.61555151111 10199.312961530775 12953.282548690755 11535.26859569068 13557.521204005081 1.0728486644882604 0.8384125278163166 0.9039407122811578 1.1380201922631712 1.1009093185087955 1.2215076268233216 0.7522992446818195 0.9554314799717352 0.8508390598926743 1.0 13.72680580628384 -7.273712062395173 24.989915759783106 0.8859284188968456 1.0367363648185424 0.2877610068015608 0.11988293506407233 1162.800208725602 2367710.6028330694 0.053395645592941667 0.036292575940397864 5.3246116446313574e-08 7.273712062395173 0.15080794592169677 EAFAQRPSS(ph)APDLMCLSPDR ddPTM_A459_Selumetinib_30min_R1 1 EAFAQRPSSAPDLMCLSPDR 20 1 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 EAFAQRPS(0.018)S(0.981)APDLMCLS(0.001)PDR 95.223 0.00058722 6262900.0 728.66 994.14 1467.9 1363.2 905.12 1081.1 914.73 985.68 463.88 887.94 True False 745.6363602744531 877.7456266368528 1268.5672425975354 1125.1427104332354 823.252055811915 1070.2251155602617 845.7311796466524 959.5365644601287 787.170479545292 1001.9157482680315 0.7442106400297654 0.8760673022199459 1.2661416339552032 1.1229913417153299 0.821677927744958 1.0681787539624101 0.8441140695798338 0.9577018488019957 0.7856653425260952 1.0 9.96854548115295 -7.2723677108962725 24.304767769922684 0.8933454741420023 0.9902127751980515 0.0705064779537925 0.15209585634343614 1483.456765674565 3299214.263148327 0.06660621658379016 0.04541337706639733 5.341119429907367e-08 7.2723677108962725 0.09686730105604924 EAFAQRPSSAPDLMCLS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 4 EAFAQRPSSAPDLMCLSPDR 20 1 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 EAFAQRPSSAPDLMCLS(1)PDR;EAFAQRPSSAPDLMCLS(1)PDR;EAFAQRPSSAPDLMCLS(1)PDR;EAFAQRPSSAPDLMCLS(1)PDR 120.8 0.00013693 31571700.0 4232.24 5188.129999999999 5564.299999999999 5883.6 5691.1 4657.8 4725.78 4464.08 2739.9399999999996 3630.3 True False 4330.842957494516 4580.7013277038 4808.698622512068 4856.139708850487 5176.341009845316 4610.946760944025 4369.310609852695 4345.678097024565 4649.478062700114 4096.284367116511 1.0572613054554894 1.1182576494141894 1.173917187272095 1.1854986796897744 1.2636673985329507 1.1256412757764178 1.0666521701784035 1.0608829142600784 1.1350476788243613 1.0 12.000100156442468 -7.093412956585028 4.674452882140433 1.0718539981185373 1.1625242474044788 0.3661778917461066 0.05782682535995681 0.2780647260166215 10.18800199430349 0.023849251943519553 0.018477343052309466 8.064678213659131e-08 7.093412956585028 0.09067024928594147 EAFAQRPSSAPDLMCLS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 2 EAFAQRPSSAPDLMCLSPDR 20 1 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 EAFAQRPS(0.001)S(0.001)APDLMCLS(0.998)PDR;EAFAQRPS(0.005)S(0.014)APDLMCLS(0.981)PDR 120.44 0.00013773 17214300.0 24314.8 23254.3 21655.8 23802.4 21319.7 22733.0 22721.4 19763.2 19050.1 21803.0 True False 22963.4807558564 25037.830035640345 20262.489405052274 20560.472058569754 18641.328685463748 25864.264400372496 23777.990121599963 19820.70764002611 22860.652304267034 21173.490739002824 1.084539202293947 1.1825083706919983 0.9569744382171037 0.9710478216374661 0.8804088525245068 1.22153993024537 1.1230075576437426 0.9361095855354258 1.0796827309233596 1.0 14.369971516476104 -5.256101210164171 24.942498858842303 1.0228009463373864 1.1335237850527486 0.17861487553197486 0.09638224494373149 776.5498189408294 3628388.2993354914 0.025951045818742347 0.06463142035804198 5.5449647525984604e-06 5.256101210164171 0.11072283871536226 EAFAQRPSSAPDLMCLS(ph)PDRK ddPTM_A459_Selumetinib_30min_R1 2 EAFAQRPSSAPDLMCLSPDRK 21 2 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 EAFAQRPS(0.001)SAPDLMCLS(0.999)PDRK;EAFAQRPSSAPDLMCLS(1)PDRK 67.827 0.0092831 27041000.0 885.04 884.47 1397.2 1240.8600000000001 1005.47 899.74 885.85 967.98 444.11 619.33 True False 905.6597100119432 780.915841221052 1207.4679142702341 1024.1670948270134 914.5254160301465 890.6894324985567 819.0296212980737 942.3060259578316 753.622233488962 698.8270382850642 1.2959711922916586 1.1174665524354002 1.7278494507501956 1.4655516153758739 1.3086577449470338 1.274549185567185 1.1720061995711974 1.3484109433863203 1.0784102391607033 1.0 9.4487916183573 -8.11137528555678 0.6206099560681134 1.0006578076626007 1.3893004172009058 0.3795264923770765 0.15712431436087795 0.8494763073295751 0.7411723706663877 0.16399907349631335 0.07896477617344477 7.737928535758058e-09 8.11137528555678 0.3886426095383051 EAFEEMEGTSPS(ph)SPPPSGVR ddPTM_A459_Selumetinib_30min_R1 1 EAFEEMEGTSPSSPPPSGVR 20 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 EAFEEMEGT(0.003)S(0.014)PS(0.47)S(0.47)PPPS(0.042)GVR 78.964 0.004682 3227700.0 406.92 414.19 548.7 508.03 626.45 464.93 615.25 618.99 266.09 434.65 True False 416.400444271513 365.6964422482931 474.18955379335625 419.3120974041935 569.7877081087308 460.2532263226644 568.8411971593835 602.5723744371144 451.53529555533066 490.44156134952766 0.8490317238321344 0.7456473330727139 0.9668624993537427 0.8549685231618418 1.161785119802795 0.9384466215632392 1.1598552039393375 1.22863236300578 0.9206709445929904 1.0 8.937937431878833 -5.921553614044135 1.2184866866398623 1.082070852432948 0.8043677584964628 0.45417082535494857 0.10974901956090707 0.40333891936590793 1.2107545666519082 0.03923467366571278 0.0829948947036225 1.197971223436773e-06 5.921553614044135 -0.2777030939364853 EAFEEMEGTSPSS(ph)PPPSGVR ddPTM_A459_Selumetinib_30min_R2 2 EAFEEMEGTSPSSPPPSGVR 20 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 EAFEEMEGTSPS(0.01)S(0.99)PPPSGVR;EAFEEMEGT(0.001)S(0.003)PS(0.03)S(0.966)PPPSGVR 208.52 5.614700000000001e-17 3224100.0 28323.0 16831.8 22736.0 20299.9 20904.6 12954.8 17616.8 19783.2 18537.2 22208.0 True False 26748.921045952313 18122.744937232743 21273.190513085097 17535.018600719264 18278.37725850484 14739.206108034381 18436.01610702696 19840.76583671494 22245.157972643672 21566.797336686435 1.2402824873979212 0.8403076569187605 0.9863861648524932 0.8130562144658878 0.847523949576519 0.683421181083855 0.8548332800283783 0.9199681124171641 1.0314539347389937 1.0 14.396524332147393 -4.758010436992266 24.997011235022327 0.8761262483713735 1.2402829970426639 0.5349232917866334 0.09859934261917047 77.88420482856355 567687.0092150107 0.02535449848441249 0.1798917004749724 1.7457801977170114e-05 4.758010436992266 0.36415674867129033 EAFEQPQTSS(ph)TPPRDLDSK ddPTM_A459_Selumetinib_30min_R1 1 EAFEQPQTSSTPPRDLDSK 19 1 P52564;A0A0A0MRF7;K7EIW3 P52564 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1 EAFEQPQT(0.114)S(0.09)S(0.384)T(0.384)PPRDLDS(0.029)K 61.524 0.019389 27419000.0 2421.9 3284.7 3674.0 4170.0 3256.9 2541.1 2745.1 2861.9 1521.9 2172.0 True False 2478.3255578029516 2900.1257969844 3175.0909798374196 3441.7877805946255 2962.3139700523993 2515.5388411341987 2538.0348969073107 2785.9931152386603 2582.553144821896 2450.797357071609 1.011232344710962 1.183339694983873 1.2955338680596789 1.4043542892942906 1.2087143645331768 1.0264164982371073 1.0355955744704815 1.136770083091475 1.053760376136409 1.0 11.25903548529523 -6.701856678440325 6.0825901782993315 1.0582637585643893 1.2346779615848487 0.4252562469800819 0.09823653976796824 0.21439457908119278 15.71405460082976 0.03551832440646659 0.03515296754778566 1.986750456874845e-07 6.701856678440325 0.1764142030204594 EAFEQPQTSST(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 EAFEQPQTSSTPPR 14 0 P52564;A0A0A0MRF7;K7EIW3 P52564 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1 EAFEQPQTSS(0.031)T(0.969)PPR;EAFEQPQTS(0.001)S(0.037)T(0.962)PPR 195.5 0.00021641 9946100.0 44311.0 29343.0 45139.0 52350.0 55138.0 40854.0 55756.0 60887.0 46598.0 35429.0 True False 41848.372010987274 31593.51374738412 42234.80588362722 45219.83969121291 48211.071500025806 46481.267664312596 58348.764478418 61064.171089614516 55918.902056904466 34406.072714403104 1.216307724463672 0.9182539957301902 1.227539284538768 1.3142982073709022 1.4012372728563014 1.3509611529959524 1.6958856351539355 1.7748079415077145 1.6252625669042327 1.0 15.070375604411076 -6.132833482490339 1.0019231883515023 1.5619521014753173 1.0645754896973842 0.3446173305781337 0.21745063626174752 0.5316490636938088 1.1082249756668046 0.09388643395310449 0.17005254065272904 7.364894286838715e-07 6.132833482490339 -0.497376611777933 EAFEQPQTSST(ph)PPRDLDSK ddPTM_A459_Selumetinib_30min_R1 1 EAFEQPQTSSTPPRDLDSK 19 1 P52564;A0A0A0MRF7;K7EIW3 P52564 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 1 EAFEQPQT(0.112)S(0.112)S(0.301)T(0.474)PPRDLDS(0.001)K 83.359 0.006352 26838000.0 3346.6 4470.5 4401.1 4876.9 4156.9 3654.0 4380.2 4008.0 1893.1 3010.5 True False 3424.569268649966 3947.091781720932 3803.454793511828 4025.2409657510616 3780.9091289603007 3617.244077566549 4049.797987480746 3901.6948201811897 3212.452433446567 3396.926999753258 1.0081374338920783 1.161959554034466 1.1196751634015387 1.1849654013887971 1.113038086845827 1.0648577605080398 1.1921945887488634 1.148595427709985 0.9456936912921323 1.0 11.730014499574642 -8.260133322759422 24.95221989665806 0.972846832655945 1.1272320292066882 0.5575103979540845 0.05387291571318034 76.81555162992152 1467642.9956211562 0.04030906324455411 0.01331506657795877 5.493721978462551e-09 8.260133322759422 0.15438519655074323 EAFSLFDKDGDGTITTK ddPTM_A459_Selumetinib_30min_R1 2 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 0 ; 171.56 1.9401e-06 139222000.0 7641.8 8420.400000000001 8651.6 10360.3 9698.7 8362.7 8151.9 8236.0 5707.5 6815.5 False True 7819.839071645651 7434.535653462248 7476.760239837073 8551.068091917145 8821.454297444556 8278.578830724076 7536.995619867662 8017.554525701668 9685.210640693183 7690.335813591874 1.0168397403173075 0.9667374525209256 0.9722280562342507 1.1119238872253165 1.1470831068070586 1.076491200305264 0.980060663481925 1.0425493398521646 1.25940022327446 1.0 12.908830882332374 -5.756976140909239 24.998911732789495 1.0874462354960452 0.9834152963994087 0.28225255631829393 0.07520547905837988 150.87436715726383 845043.4849930408 0.02104933413946967 0.03492324891948663 1.7499428236195466e-06 5.756976140909239 -0.10403093909663652 EAFSLFDKDGDGTITTK ddPTM_A459_Selumetinib_30min_R2 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 0 102.64 0.009872399999999998 10270000.0 20926.0 19122.0 32781.0 28824.0 26314.0 23030.0 22066.0 16920.0 22487.0 25094.0 False True 19763.01669341517 20588.595913079072 30671.906149254144 24898.12147582659 23008.20006985525 26202.17345447495 23092.1127229495 16969.234398743203 26985.028339276574 24369.47101795791 0.8109743817931775 0.8448519829547099 1.2586201040905631 1.0216931445692488 0.94414031609059 1.0752048509861587 0.9475836675294625 0.6963316678576462 1.107329261246223 1.0 14.572787314728403 -7.519650364641394 24.99777309099165 0.9054898438012272 0.9982728572546246 0.01966585696955525 0.15139854975193376 411.02637856391766 3182709.8366504903 0.07055296898719234 0.041783386970735095 3.022383957254432e-08 7.519650364641394 0.09278301345339734 EAGAGGLAIAVEGPSK ddPTM_A459_Selumetinib_30min_R2 1 EAGAGGLAIAVEGPSK 16 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 135.81 0.0062326000000000005 0.0 12738.0 16042.0 19178.0 20320.0 16739.0 10756.0 9585.3 10302.0 8430.1 14837.0 False True 12030.07295425416 17272.369816840008 17944.108359427602 17552.380946044836 14636.097171441337 12237.541366753469 10031.035442911618 10331.977114412091 10116.355556674322 14408.617258844419 0.8349220982235307 1.1987527676354743 1.2453733787961505 1.2181863554790926 1.0157877684242937 0.8493210102615306 0.6961830731366179 0.7170693015716015 0.7021045375096361 1.0 13.814644271653004 -6.728184860070001 2.5092601276719684 0.7574131425740862 1.136859296994163 0.5735616282631169 0.1356239330575135 0.18863878970810005 2.43309817756227 0.05082701230157291 0.04801003394551112 1.8698860426549972e-07 6.728184860070001 0.3794461544200769 EAGELPT(ph)SPLHLLSPGTPR ddPTM_A459_Selumetinib_30min_R2 2 EAGELPTSPLHLLSPGTPR 19 0 Q969R5;H7C228;Q969R5-2;Q969R5-3 Q969R5 L3MBTL2 Lethal(3)malignant brain tumor-like protein 2 1 EAGELPT(0.898)S(0.102)PLHLLSPGTPR;EAGELPT(0.628)S(0.372)PLHLLSPGTPR 204.9 1.2786e-15 8032000.0 36994.0 29000.0 42487.0 47825.0 51476.0 34521.0 36995.0 42713.0 41275.0 32624.0 True False 34938.02157871553 31224.206750302976 39753.43267634793 41311.15249727332 45009.12467872121 39275.95439956272 38715.34080420179 42837.28775848221 49531.153319857774 31682.060352668326 1.1027698700716912 0.9855484903043312 1.2547615980095126 1.303928849242092 1.4206501779777858 1.2396906628660853 1.2219956774667626 1.3520991779461202 1.563381698301896 1.0 14.951378539585729 -5.386237166685797 4.204865443036802 1.3121537587747214 1.0454813090899053 0.3398102510517652 0.13964537944774813 0.22905594146648162 6.64882363191533 0.036094461579355634 0.08003725721493 4.1092525498667454e-06 5.386237166685797 -0.26667244968481607 EAGELPTS(ph)PLHLLSPGTPR ddPTM_A459_Selumetinib_30min_R1 2 EAGELPTSPLHLLSPGTPR 19 0 Q969R5;H7C228;Q969R5-2;Q969R5-3 Q969R5 L3MBTL2 Lethal(3)malignant brain tumor-like protein 2 1 EAGELPT(0.148)S(0.852)PLHLLSPGTPR;EAGELPT(0.124)S(0.876)PLHLLSPGTPR 137.45 0.00010638 25970000.0 3785.7 5122.3 3451.1000000000004 3032.1 4173.9 3467.6000000000004 5220.4 5306.6 2278.8999999999996 4699.5 True False 3873.8994443101 4522.578734707338 2982.4595755353594 2502.600654566179 3796.371481961894 3432.7190923288904 4826.621025031845 5165.851729733911 3867.1268557294266 5302.726602006456 0.7305485903882516 0.8528779765858712 0.5624388733160126 0.4719460086098423 0.7159281944736535 0.6473498164189743 0.9102149492688419 0.9741878315542887 0.7292714005406531 1.0 12.372518652583079 -7.262151332728496 24.932475048768488 0.901267543090753 0.6612026960563773 0.5055705436940993 0.11620483382467538 56.703371998193276 1985683.6219938728 0.0491745351412888 0.03539192179042622 5.468253848404656e-08 7.262151332728496 -0.2400648470343757 EAGELPTS(ph)PLHLLSPGTPR ddPTM_A459_Selumetinib_30min_R2 2 EAGELPTSPLHLLSPGTPR 19 0 Q969R5;H7C228;Q969R5-2;Q969R5-3 Q969R5 L3MBTL2 Lethal(3)malignant brain tumor-like protein 2 1 EAGELPT(0.038)S(0.962)PLHLLSPGTPR;EAGELPT(0.455)S(0.545)PLHLLSPGTPR 139.95 8.285100000000001e-05 23159000.0 33259.3 22535.7 29985.0 39144.0 47949.0 36699.8 36740.0 39816.0 39633.0 34246.0 True False 31410.881253526873 24264.115726303535 28055.79774519952 33812.519672833616 41925.21795050123 41754.864322385554 38448.482798928875 39931.85796810638 47560.70743854444 33257.228998206236 0.9444828147053699 0.729589218861627 0.8435999808256046 1.016696841298995 1.2606347315575364 1.2555124278284775 1.1560939969172608 1.2006970866472413 1.4300862961586391 1.0 15.02138034742037 -5.997851686327884 2.682013204704119 1.2258959077537235 0.8265842195599831 0.6972939049189519 0.11190018625905825 0.14171127019602825 2.058989958780665 0.03312383395752212 0.04986462866476153 1.0049589300322756e-06 5.997851686327884 -0.3993116881937404 EAGEMESSTLQES(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 EAGEMESSTLQESPR 15 0 Q2M1Z3 Q2M1Z3 ARHGAP31 Rho GTPase-activating protein 31 1 EAGEMESSTLQES(1)PR 109.48 0.0049496 0.0 7305.6 11313.0 10244.0 8559.1 7595.5 6477.3 8153.5 8636.0 6690.5 8726.3 True False 6899.583998633947 12180.670722971636 9584.912192823878 7393.335814728948 6641.28538536846 7369.4892799249055 8532.653905853742 8661.129330233232 8028.786948189176 8474.349045349729 0.8141727419665432 1.4373576846773546 1.1310499651986328 0.8724370184853333 0.7836926883502449 0.8696230519285595 1.0068801580147335 1.0220406645848508 0.9474222627866558 1.0 13.048886836968375 -5.7053588550085745 6.665309948306107 0.9246741047184369 1.16171864379446 0.24496527043305172 0.1566516020985357 0.2498862997999692 22.720523024620583 0.04206997179403425 0.07278235848435254 1.970793607823605e-06 5.7053588550085745 0.23704453907602308 EAGENAPVLS(ph)DDELVSMSVR ddPTM_A459_Selumetinib_30min_R1 2 EAGENAPVLSDDELVSMSVR 20 0 O60675 O60675 MAFK Transcription factor MafK 1 EAGENAPVLS(1)DDELVSMSVR;EAGENAPVLS(1)DDELVSMSVR 269.39 6.5184e-59 13856600.0 2862.6000000000004 3102.3 3389.0 3687.3 3656.8999999999996 3282.0 3216.2 2985.3 1994.0700000000002 2954.5 True False 2929.293010350026 2739.0812737798583 2928.792414444477 3043.3822741934187 3326.1340406781314 3248.986059817575 2973.5994446225245 2906.120146378969 3383.791148889543 3333.738854267067 0.8786810060424005 0.8216244263625905 0.8785308455387041 0.9129036217992893 0.9977188334415572 0.9745772545018002 0.8919713194740564 0.8717299924855357 1.015013861856159 1.0 11.702925381065057 -5.798122101252574 2.7080379422092524 0.9496797695019606 0.8513403060769336 0.4749120924841742 0.04613473305639734 0.25410995834323924 3.797594921402833 0.01408597959469843 0.024502714077716602 1.5917611428394092e-06 5.798122101252574 -0.09833946342502708 EAGEQGDIEPR ddPTM_A459_Selumetinib_30min_R2 1 EAGEQGDIEPR 11 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 155.53 0.0074171 11993000.0 59441.0 52393.0 72382.0 68879.0 68089.0 51672.0 54027.0 47988.0 47711.0 56501.0 False True 56137.50718117614 56411.374629952516 67725.02092356289 59497.561377097576 59535.05109661679 58789.34896828609 56539.36255246951 48127.63713515892 57254.53315672282 54869.66932277201 1.0231063513604584 1.028097586994946 1.2342888477269471 1.0843433560188214 1.0850266063460412 1.0714361812982047 1.0304301675279923 0.8771264293948458 1.043464155395612 1.0 15.743721260845945 -7.407761443573913 3.180395446641292 0.9682402329457532 1.0919162332129542 0.3604800569981089 0.06728453277642722 0.26937686708163355 5.144496861421379 0.032216621232930294 0.020035759297474354 3.910556422913528e-08 7.407761443573913 0.12367600026720094 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDK ddPTM_A459_Selumetinib_30min_R1 1 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 31 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 115.34 1.2798e-15 6185100.0 836.94 791.62 446.84 662.26 785.94 588.94 750.69 694.58 171.45 325.29 False True 856.4390735982503 698.9367623858464 386.1615823164268 546.6087231598553 714.8518657689771 583.0157983147353 694.064848916014 676.1574820861906 290.93812778744575 367.04414009292043 2.3333408166697205 1.9042308159691759 1.0520848588365057 1.489217953517734 1.9475910052344279 1.588407863335292 1.8909574438112684 1.842169396615392 0.7926516078251303 1.0 8.519809759284472 -8.261630699687597 24.99998495091589 0.8963257141522804 1.7338830248246757 0.5317510304854909 0.32215011509126495 14.220550434059312 1857496.2353591914 0.2684452417735082 0.08599533061927304 5.474813132247744e-09 8.261630699687597 0.8375573106723954 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDK ddPTM_A459_Selumetinib_30min_R2 1 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 31 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 107.13 5.9739e-11 3176200.0 28949.0 25539.0 35010.0 44414.0 47894.0 33252.0 25390.0 31900.0 35010.0 36892.0 False True 27340.13047202886 27497.759179171997 32757.494716005862 38364.736581576515 41877.127542207476 37832.161168397746 26570.685309330536 31992.82371867072 42012.97826113192 35826.8321030726 0.7631188376737362 0.7675185765814254 0.9143285295714576 1.0708380933933106 1.1688760932512363 1.055972826722605 0.7416420528861598 0.8929850014823648 1.1726679640628561 1.0 15.128752862081067 -5.409199994059051 3.2143443659202355 1.0066326918342916 0.7635160207729369 0.40243069861220093 0.12019254984408437 0.283362200717011 5.446204402585597 0.036129705430916835 0.08514498254358874 3.89762458429491e-06 5.409199994059051 -0.2431166710613547 EAGS(ph)PAQEFK ddPTM_A459_Selumetinib_30min_R1 4 EAGSPAQEFK 10 0 Q5JSZ5;Q5JT00;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 EAGS(1)PAQEFK;EAGS(1)PAQEFK;EAGS(1)PAQEFK;EAGS(1)PAQEFK 179.59 0.00011122 152916000.0 21812.199999999997 24905.9 21473.399999999998 21891.9 20454.399999999998 18975.5 22641.300000000003 22430.8 11839.2 19497.6 True False 22320.381820847088 21989.905649561224 18557.430224943066 18068.890626858392 18604.303131517634 18784.623698375504 20933.4485123848 21835.862318493066 20090.257699044196 22000.306882706907 1.014548657882212 0.9995272232700599 0.843507789408607 0.8213017537978636 0.8456383463514928 0.8538346214225286 0.9515071141502712 0.9925253513466623 0.9131807936204707 1.0 14.425236027620816 -7.419301105200781 6.324699953477518 0.9660254955059198 0.8931687427240775 0.2097909452360408 0.06492073084213547 0.43076331793711903 22.314703916537905 0.031029623348134396 0.020682129289258652 3.808017142716598e-08 7.419301105200781 -0.07285675278184223 EAGS(ph)PAQEFK ddPTM_A459_Selumetinib_30min_R2 4 EAGSPAQEFK 10 0 Q5JSZ5;Q5JT00;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 EAGS(1)PAQEFK;EAGS(1)PAQEFK;EAGS(1)PAQEFK;EAGS(1)PAQEFK 143.55 0.001078 183169100.0 210175.0 180650.0 210137.0 209971.0 217844.0 159676.0 186269.0 189495.0 142443.0 186281.0 True False 198494.31489718685 194505.2741186976 196617.0141998664 181372.5875798217 190476.48916993034 181669.91960559008 194930.87758502137 190046.39907741407 170935.58018995714 180902.58351383693 1.0972442241655678 1.0751934568354033 1.0868668118541684 1.002598105880278 1.0529229902090431 1.004241708862574 1.0775461234367139 1.0505455222693254 0.9449040299464964 1.0 17.4648534860222 -1.522878745288224 0.19489718087901572 0.9922755053730838 1.4857578086460106 0.42872998544144336 0.03522043030512263 56.29419865606815 0.669017482907351 0.06898821871684331 8.417335559467965 0.029999999999455226 1.522878745288224 0.49348230327292675 EAGT(ph)PSLDSEAK ddPTM_A459_Selumetinib_30min_R1 2 EAGTPSLDSEAK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 EAGT(0.956)PS(0.04)LDS(0.004)EAK;EAGT(0.994)PS(0.006)LDSEAK 142.1 0.00219 28575000.0 6880.4 7781.6 8510.2 8199.7 7397.4 6924.5 7824.900000000001 6917.8 4756.0 6129.4 True False 7040.699933072147 6870.526654432308 7354.561583182472 6767.7763224320715 6728.306476117043 6854.845816942954 7234.661493136866 6734.317471818723 8070.584635503604 6916.168195411934 1.0180058862279875 0.9934007473950816 1.0633867447094998 0.97854420702517 0.9728373119353119 0.9911334749623845 1.0460505425440947 0.9737064341908503 1.1669156109964893 1.0 12.755757239202735 -8.233588614682246 24.94354153344027 1.0834579084772418 1.005218301669706 0.30889662424128017 0.04715490564991106 690.1147138780303 618078.6339585928 0.02967812650175029 0.011210295316353034 5.8399803431387776e-09 8.233588614682246 -0.07823960680753572 EAGT(ph)PSLDSEAK ddPTM_A459_Selumetinib_30min_R2 2 EAGTPSLDSEAK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 EAGT(0.994)PS(0.006)LDSEAK;EAGT(0.973)PS(0.025)LDS(0.003)EAK 146.79 0.0015132 48220000.0 430240.0 380210.0 371030.0 422330.0 408490.0 296160.0 361810.0 324020.0 284590.0 342790.0 True False 406328.9831871806 409370.88443216216 347158.33374691906 364807.9254401141 357171.83425306616 336953.3517271946 378634.88191291434 324962.844555601 341515.95210898464 332892.76202461903 1.2206002338889261 1.2297380151566264 1.0428533550430423 1.0958722058761217 1.0729336140587267 1.0121978912304357 1.1374079736972846 0.9761787627319107 1.0259038076764428 1.0 18.344697977222864 -1.5228787474647445 0.37510851491101926 1.0181360891874318 4.252770268814305 0.6596433068368679 0.049451948538446346 39.311326216806464 0.5399080063506201 0.037686610222062766 92.03676831128168 0.029999999849106514 1.5228787474647445 3.234634179626873 EAIEGTYIDKK ddPTM_A459_Selumetinib_30min_R1 1 EAIEGTYIDKK 11 1 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 105.17 0.016035 14655000.0 1095.3 1495.5 1234.3 1399.3 972.97 1510.0 918.34 1245.0 811.29 973.7 False True 1120.818358917202 1320.406164760912 1066.6888395245846 1154.9385231141628 884.9650352918059 1494.8107709703042 849.0688744402247 1211.9785556700556 1376.6998757228164 1098.683879641172 1.0201463584623258 1.201807170586824 0.9708787571116116 1.0512018466051976 0.8054774004519241 1.3605467402129412 0.7728054358252064 1.1031185385789817 1.253044575635754 1.0 10.10156062920335 -7.989557803983722 24.99299621263197 1.1437088238027575 1.0290866968212398 0.05722049917084204 0.17086340479964848 526.6883599028287 1260606.8252623964 0.08824858742220458 0.042328096936118075 1.02433543363364e-08 7.989557803983722 -0.11462212698151775 EAIEGTYIDKK ddPTM_A459_Selumetinib_30min_R2 1 EAIEGTYIDKK 11 1 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 100.09 0.022479 9167200.0 44967.0 51423.0 43791.0 35656.0 41103.0 41203.0 40029.0 38489.0 32445.0 37333.0 False True 42467.914157163344 55366.978748994145 40973.53473603579 30799.591289969205 35939.27367451777 46878.33924640604 41890.42781595874 38600.99661780303 38934.906589043865 36255.09928721699 1.1713638906551527 1.5271501068131323 1.1301454289626633 0.8495243950643017 0.9912887947100293 1.2930136771942216 1.1554354736170502 1.0647053070245809 1.0739153210034578 1.0 15.14589630430444 -5.457468783897381 8.597868518609106 1.068081420539429 1.3456468802433703 0.4171828848574646 0.13412981657832732 0.36698088637421006 45.2364958972098 0.03637669560207246 0.07571056923617343 3.4876365157478376e-06 5.457468783897381 0.2775654597039414 EAILAIHK ddPTM_A459_Selumetinib_30min_R1 2 EAILAIHK 8 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ; 117.04 0.012726 33686000.0 23597.0 26814.0 27208.0 28289.0 26340.0 23083.0 24402.0 23099.0 13986.0 20534.2 False True 24146.76418823082 23674.604414509602 23513.303042846066 23348.857200297673 23957.551650704692 22850.805977687098 22561.337493837087 22486.339483873584 23733.220502975902 23169.96459004596 1.0421580099697045 1.0217799134954413 1.0148182553955047 1.007720884059036 1.0339917248296997 0.9862253301631726 0.973732066190971 0.9704952028081186 1.0243097442268825 1.0 14.499968218926801 -6.771416663758173 24.996257704194488 0.9880321360181812 1.0225403009356635 0.49274429866981284 0.016644545148389648 173.18529863150482 433880.52967355173 0.0058683841892501285 0.005233839890464054 1.692713025925666e-07 6.771416663758173 0.03450816491748232 EAILAIHK ddPTM_A459_Selumetinib_30min_R2 1 EAILAIHK 8 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 105.57 0.019808000000000003 10537000.0 188430.0 172960.0 195020.0 204600.0 211840.0 171380.0 157850.0 160920.0 149850.0 170940.0 False True 177957.81494505494 186225.47584594518 182472.62552172103 176733.12704531392 185226.76532637136 194986.03936725642 165190.33777384128 161388.25055826004 179824.1871588298 166004.51804454153 1.07200585286062 1.12180968349294 1.0992027667148243 1.0646284157030819 1.1157935188045436 1.1745827262059139 0.9950954330623593 0.9721919165775785 1.0832487529681585 1.0 17.340862981501502 -7.282988259064493 24.796270882079437 1.01031667354756 1.1066137882020863 0.5913641250340784 0.038808598184773085 527.2202001711538 606668.7816613875 0.016269140926497165 0.010979980286958459 5.2120880153556415e-08 7.282988259064493 0.0962971146545264 EAIS(ph)DEDEDEALYQK ddPTM_A459_Selumetinib_30min_R1 2 EAISDEDEDEALYQK 15 0 Q9C0B7 Q9C0B7 TANGO6 Transport and Golgi organization protein 6 homolog 1 EAIS(1)DEDEDEALYQK;EAIS(1)DEDEDEALYQK 241.3 3.4876e-20 6629600.0 2076.12 2844.7 2694.6 3196.3 2815.7 2492.2 2302.77 2048.5699999999997 1127.48 2124.82 True False 2124.4895565737093 2511.6412015348496 2328.6881203783087 2638.126206981917 2561.0204321522115 2467.130730736549 2129.070204929236 1994.2352689068325 1913.2512121189231 2397.5613444994906 0.8861043582670928 1.0475816217579093 0.9712736342370586 1.1003373127592055 1.0681772285108493 1.0290167283505238 0.8880149030654712 0.831776535554357 0.7979988568419004 1.0 11.227352013470867 -7.316484430179465 4.425527247909616 0.8617977871523103 1.0228003021977046 0.4502494559846457 0.07371563308754359 0.18232452866662888 7.573986699154564 0.03140593703593801 0.02106582138774859 4.8252027850531775e-08 7.316484430179465 0.1610025150453943 EAIS(ph)DEDEDEALYQK ddPTM_A459_Selumetinib_30min_R2 1 EAISDEDEDEALYQK 15 0 Q9C0B7 Q9C0B7 TANGO6 Transport and Golgi organization protein 6 homolog 1 EAIS(1)DEDEDEALYQK 101.72 0.006759 1997100.0 10486.0 8774.5 12121.0 12994.0 17308.0 12046.0 9725.9 13365.0 11472.0 14643.0 True False 9903.230098783888 9447.47593553563 11341.148056346963 11224.194784099724 15133.614304516792 13705.227157299398 10178.173621505242 13403.88993730514 13766.720554461726 14220.21854291694 0.6964189804042544 0.6643692505162937 0.7975368326526855 0.7893123970088681 1.0642321887559747 0.9637845660343907 0.7157536707883416 0.9425938073210266 0.9681089297547328 1.0 13.795656016683973 -5.7704043041975925 1.9288959703458766 0.9272398948795973 0.6891800601687358 0.5498272941678015 0.09133941067294876 0.27618736804548605 2.096857529151875 0.029579428316515447 0.05876376536526834 1.6966634170032178e-06 5.7704043041975925 -0.23805983471086156 EAKPGAAEPEVGVPSSLSPS(ph)SPSSSWTETDVEER ddPTM_A459_Selumetinib_30min_R1 2 EAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEER 34 1 F6T1Q0;Q6L8Q7-2;Q6L8Q7 F6T1Q0 PDE12 2,5-phosphodiesterase 12 1 EAKPGAAEPEVGVPS(0.004)S(0.004)LS(0.004)PS(0.491)S(0.491)PS(0.004)S(0.001)SWTETDVEER;EAKPGAAEPEVGVPS(0.004)S(0.005)LS(0.004)PS(0.764)S(0.167)PS(0.051)S(0.004)S(0.001)WTETDVEER 112.13 7.601699999999999e-15 13589000.0 3211.3 3535.1 4136.2 3729.3 4245.9 3215.3 3954.7 3195.8999999999996 1793.9 2957.6000000000004 True False 3286.1170418979386 3121.2088485765967 3574.526758520284 3078.0477626310626 3861.8590946745285 3182.9570012588197 3656.393795052763 3111.134350253759 3044.1172787279024 3337.236769463622 0.9846820195577854 0.9352674275724985 1.0711037320539893 0.9223342469422038 1.1572026084607796 0.9537702060529559 1.095635116006599 0.9322486132003743 0.9121670079216971 1.0 11.70443833079075 -7.829246602340768 24.99976440537941 0.9416551229765223 1.0153736365359627 0.1546801405211451 0.0733728339570512 94.10070397980448 34691.46993879227 0.03781870219289884 0.018167520756007444 1.4816765164200583e-08 7.829246602340768 0.07371851355944037 EALAEAALES(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 EALAEAALESPR 12 0 J3QRP6;O14745;O14745-2 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 EALAEAALES(1)PR 92.039 0.022215 1430800.0 6650.9 4994.0 5743.4 6824.4 7157.1 5438.8 6545.6 7558.0 7921.4 6474.9 True False 6281.2696036621865 5377.02374175907 5373.875896941104 5894.904947253359 6257.961112714188 6187.945331489287 6849.983369860337 7579.9925287057395 9505.901342408753 6287.952813189436 0.9989371406361016 0.8551310579940061 0.8546304427840188 0.9374919186556823 0.9952302917394135 0.9840953829217077 1.0893821205992515 1.2054785959599055 1.5117641026932387 1.0 12.618374675853863 -7.4775081675802895 1.6321526547096419 1.2758324281838094 0.923075977628776 0.5418237925097582 0.12476444747984367 0.2705790036289257 1.398882937811973 0.0772757338087291 0.038968598978555855 3.330364989827403e-08 7.4775081675802895 -0.35275645055503335 EALAEAALES(ph)PRPALVR ddPTM_A459_Selumetinib_30min_R1 5 EALAEAALESPRPALVR 17 1 J3QRP6;O14745;O14745-2 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 EALAEAALES(1)PRPALVR;EALAEAALES(1)PRPALVR;EALAEAALES(1)PRPALVR;EALAEAALES(1)PRPALVR;EALAEAALES(1)PRPALVR 199.91 3.1605e-08 998709800.0 10541.099999999999 13201.8 14028.2 14232.0 13388.9 10414.1 13027.7 12064.099999999999 6774.610000000001 10204.0 True False 10786.687120589899 11656.127118649687 12123.24749138684 11746.648367727266 12177.876359002283 10309.34360924625 12045.010100338564 11744.120878280411 11496.018372062463 11513.782795376936 0.9368499747034499 1.0123629501965163 1.0529334890922746 1.0202249405333434 1.0576781389251149 0.8953915313901617 1.0461383816598424 1.0200054219362173 0.9984571166896073 1.0 13.491074281093342 EALAEAALES(ph)PRPALVR ddPTM_A459_Selumetinib_30min_R2 3 EALAEAALESPRPALVR 17 1 J3QRP6;O14745;O14745-2 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 EALAEAALES(1)PRPALVR;EALAEAALES(1)PRPALVR;EALAEAALES(1)PRPALVR 159.95 1.5673e-05 563020000.0 73440.0 72324.0 93582.0 99820.0 111186.0 71842.0 70318.0 68881.0 74508.0 83645.0 True False 69358.49880361326 77871.01824168675 87561.03600437741 86224.3438008956 97217.82066454852 81737.58338325622 73587.92633247362 69081.4323061366 89411.68192746126 81229.95151419009 0.853853751119093 0.958649079435723 1.0779402716876094 1.061484614893966 1.1968223401877263 1.0062493188731925 0.9059210914291697 0.8504428602800377 1.1007230739494152 1.0 16.309724162791674 -10.28314360180549 13.38771848178403 1.000000049111093 1.0027579053633888 0.0 0.10633290218651753 0.0 0.0 0.11060662737692578 0.02682604750402348 5.21022403760318e-11 10.28314360180549 0.002757856252295854 EALASLPSS(ph)PGLLQSLLER ddPTM_A459_Selumetinib_30min_R1 2 EALASLPSSPGLLQSLLER 19 0 P41229-4;P41229-3;P41229-2;P41229-5;P41229 P41229-4 KDM5C Lysine-specific demethylase 5C 1 EALASLPS(0.1)S(0.9)PGLLQSLLER;EALASLPS(0.005)S(0.995)PGLLQSLLER 220.42 2.8963e-19 20739200.0 3961.9 5050.3 4924.0 5301.3 5066.4 4425.5 5052.2 4534.4 2267.8 3750.0 True False 4054.204561484583 4459.008528179229 4255.34784559593 4375.5274727257265 4608.145014545567 4380.9834880325 4671.108486450446 4414.132982193011 3848.2909664413514 4231.349028093245 0.9581352269849297 1.0538030539609193 1.0056716705105984 1.0340738718728322 1.0890486660284124 1.0353632987838595 1.1039289019736973 1.0431975601365444 0.9094714099194722 1.0 12.046901977761474 -8.241199861126903 24.19842841459699 0.9547357182796951 1.0430518824297306 0.3835391979805193 0.0433392157262052 453.9827974044321 542785.5529074549 0.028885455886011612 0.010882196794304563 5.738523161736937e-09 8.241199861126903 0.08831616415003551 EALATLPS(ph)SPGLLR ddPTM_A459_Selumetinib_30min_R2 2 EALATLPSSPGLLR 14 0 E9PFH2;Q9BY66-2;Q9BY66;Q9BY66-3 E9PFH2 KDM5D Lysine-specific demethylase 5D 1 EALATLPS(0.5)S(0.5)PGLLR;EALATLPS(0.5)S(0.5)PGLLR 134.06 0.00067574 4231100.0 28644.0 28304.0 34225.0 35595.0 35223.0 29285.0 23492.8 23932.1 26164.0 31344.0 True False 27052.081151017126 30474.82578829568 32023.000761362473 30746.899595200095 30797.971842384737 33318.742927238316 24585.261750100068 24001.738448827553 31397.53108324066 30439.01727850775 0.8887304377634406 1.0011764016380782 1.0520379310659658 1.0101147259083734 1.0117925805748806 1.0946063935764403 0.8076890763309604 0.7885188351916538 1.0314896435703822 1.0 14.89363416183672 -7.261897088964701 24.99999364414198 0.8893009606348066 1.0113862285692492 0.24825595059531502 0.08545061103406705 50.72848002272369 2770689.5098246853 0.0340320602285781 0.02457801278112849 5.4714559992987695e-08 7.261897088964701 0.12208526793444263 EALEAYRR ddPTM_A459_Selumetinib_30min_R1 1 EALEAYRR 8 1 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 0 93.429 0.032575 2054800.0 1021.2 1042.8 1774.4 1827.9 1457.5 1376.8 1028.4 927.78 660.16 889.37 False True 1044.9919730907027 920.7084912154328 1533.4462260815228 1508.6915789325935 1325.6693823425248 1362.9506420343798 950.8269600304104 903.1722605458343 1120.2433038212896 1003.529302697411 1.041316850720595 0.9174704602452941 1.5280532635765942 1.5033856758117021 1.3210071482509036 1.3581572938337438 0.947483005702633 0.8999959025792027 1.1163035307590523 1.0 9.970867028157862 -7.265801283942655 24.89700207434439 0.9826119200498357 1.2853676671675396 0.37148731841802585 0.18279525901480184 425.70537722760514 2429838.331799838 0.08310648212511287 0.058250245693892436 5.422489454170222e-08 7.265801283942655 0.3027557471177039 EALGLGPPAAQLT(ph)PPPAPVGLR ddPTM_A459_Selumetinib_30min_R1 2 EALGLGPPAAQLTPPPAPVGLR 22 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 EALGLGPPAAQLT(1)PPPAPVGLR;EALGLGPPAAQLT(1)PPPAPVGLR 242.22 1.983e-36 102571000.0 4861.5 6468.0 5339.9 6076.8 5893.2 5181.700000000001 6360.6 6623.8 3181.7 4636.5 True False 4974.7634911677005 5710.723553108378 4614.770909971104 5015.600955663652 5360.161100528965 5129.576802607166 5880.814821051562 6448.115306865311 5399.112517826284 5231.639938334489 0.9508994406735557 1.091574271245893 0.882088783701776 0.958705303649086 1.0245661329352478 0.9804911773496755 1.124086307614614 1.232522762053478 1.0320114880736824 1.0 12.353047537070248 -7.260060193496765 24.650698552045398 1.1165320423960294 0.9828140780700473 0.3397814423600152 0.07717326445902889 101.74112775938491 1818479.7179188067 0.029905783022934684 0.02186108497833376 5.494647124143503e-08 7.260060193496765 -0.13371796432598215 EALGLGPPAAQLT(ph)PPPAPVGLR ddPTM_A459_Selumetinib_30min_R2 5 EALGLGPPAAQLTPPPAPVGLR 22 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 EALGLGPPAAQLT(1)PPPAPVGLR;EALGLGPPAAQLT(1)PPPAPVGLR;EALGLGPPAAQLT(1)PPPAPVGLR;EALGLGPPAAQLT(1)PPPAPVGLR;EALGLGPPAAQLT(1)PPPAPVGLR 141.79 1.4352e-05 50466700.0 118259.7 98670.6 118614.6 122899.6 129568.3 103428.0 97057.1 118184.5 103712.7 122726.1 True False 111687.29930508789 106238.3177440155 110983.06577381193 106160.46246636455 113290.77179870136 117674.26817409617 101570.44746499507 118528.39732850269 124458.13797495826 119182.67861229813 0.9371101623618249 0.8913905861237545 0.9312013043006058 0.8907373428961526 0.9505640678477854 0.9873437108834512 0.8522249092538376 0.9945102653219952 1.0442636415298336 1.0 16.86281505171364 -7.9577781869996125 10.25353342536422 1.0212435503923687 0.9220632984359894 0.585298357781795 0.03628356414436204 0.28253814930739746 66.8485197862212 0.019383565372743505 0.009283588891538316 1.1021020570699335e-08 7.9577781869996125 -0.09918025195637925 EALGQNEES(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EALGQNEESPK 11 0 Q9H8Y5;B8ZZS4 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 1 EALGQNEES(1)PK 96.135 0.020531 30043000.0 103290.0 71880.0 95793.0 88095.0 109550.0 78091.0 98981.0 110100.0 82780.0 83568.0 True False 97549.55530263088 77392.96486937159 89629.7826715325 76096.30902764865 95787.34961057399 88847.32641048216 103583.81262713054 110420.37277196387 99338.31306645242 81155.17470426015 1.2020127571422765 0.953641775172088 1.1044247393731197 0.9376642870273318 1.1802987296821843 1.0947832560801354 1.2763673173596535 1.3606079116254737 1.2240539611731964 1.0 16.308395467941388 -6.893670518674233 1.7950465937345554 1.2404237897204238 1.053707050320801 0.2221933617113374 0.11764486539958889 0.40686882898838134 2.685094718631399 0.04957737471516583 0.041039572305725316 1.2774075577609255e-07 6.893670518674233 -0.18671673939962274 EALPWGLEPQDVQSS(ph)DEMRSPEGYLR ddPTM_A459_Selumetinib_30min_R1 1 EALPWGLEPQDVQSSDEMRSPEGYLR 26 1 Q9H5H4 Q9H5H4 ZNF768 Zinc finger protein 768 1 EALPWGLEPQDVQS(0.303)S(0.39)DEMRS(0.306)PEGY(0.001)LR 87.23700000000002 3.9837e-05 7516500.0 695.09 907.29 1016.4 1079.6 1145.9 884.05 1051.6 765.58 362.0 623.64 True False 711.2842445903027 801.0640650123227 878.3784626855613 891.0681266019084 1042.2535473250764 875.1572596531769 972.2769653519821 745.2743314456882 614.2875605660857 703.6902687680192 1.0107916453578059 1.138375931238583 1.2482458571203154 1.2662788817045028 1.4811254234761473 1.2436682706801563 1.3816831189866945 1.0590942699129149 0.8729516206633714 1.0 9.458796752105203 -7.957117330982269 5.481848826089265 0.9438787037996731 1.2564961788665412 0.5307438422644338 0.12219786887455583 0.1460020110044488 10.473338548614077 0.07591691089531535 0.03459438583862832 1.1037803772647974e-08 7.957117330982269 0.3126174750668681 EALPWGLEPQDVQSSDEMRS(ph)PEGYLR ddPTM_A459_Selumetinib_30min_R1 1 EALPWGLEPQDVQSSDEMRSPEGYLR 26 1 Q9H5H4 Q9H5H4 ZNF768 Zinc finger protein 768 1 EALPWGLEPQDVQS(0.017)S(0.017)DEMRS(0.91)PEGY(0.055)LR 81.48 7.167600000000001e-05 6704200.0 846.83 966.22 1450.4 1213.9 1215.0 1106.9 982.77 800.17 473.37 773.11 True False 866.5594913556607 853.094513216508 1253.443646476916 1001.9151527251355 1105.103464525673 1095.7655909847872 908.6388676673333 778.9468922815323 803.2743164231154 872.3461992291117 0.9933665007326625 0.9779311401486974 1.436864913935062 1.1485292807036052 1.2668175381542877 1.2561132173821703 1.0416035152904815 0.8929332104271035 0.9208205608426622 1.0 9.76875698623344 -7.497310070393456 4.214232823849761 0.9331470650453275 1.184107701292808 0.4233932791185745 0.12757769770413704 0.21099226485845765 8.661037022634629 0.06276097147907796 0.038286339345583655 3.1819249323972915e-08 7.497310070393456 0.25096063624748055 EALPWGLEPQDVQSSDEMRS(ph)PEGYLR ddPTM_A459_Selumetinib_30min_R2 2 EALPWGLEPQDVQSSDEMRSPEGYLR 26 1 Q9H5H4 Q9H5H4 ZNF768 Zinc finger protein 768 1 EALPWGLEPQDVQS(0.011)S(0.028)DEMRS(0.744)PEGY(0.216)LR;EALPWGLEPQDVQS(0.017)S(0.059)DEMRS(0.903)PEGY(0.022)LR 78.531 8.8964e-05 4369900.0 15609.7 16747.7 17949.8 19433.3 24341.8 13231.099999999999 15945.5 16525.5 12928.900000000001 19178.3 True False 14742.175364580087 18032.19473765685 16794.92941026456 16786.451015687635 21283.765465546952 15053.563925032719 16686.997345408836 16573.58646905621 15515.041263648918 18624.57264779239 0.7915443561239248 0.9681937448263676 0.9017618673927158 0.9013066411312997 1.1427787293723362 0.808263588631498 0.8959667242290674 0.8898774099399651 0.8330414639332919 1.0 14.184919701984168 -10.311607751889774 18.064804982079735 0.9999999999982506 0.9090103612386705 0.0838105343147505 0.09408393327093842 0.0 0.0 0.08986269756484952 0.02179490552134174 4.8796901726148666e-11 10.311607751889774 -0.0909896387595801 EALQDVEDENQ ddPTM_A459_Selumetinib_30min_R2 2 EALQDVEDENQ 11 0 P62258;P62258-2;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 ; 148.94 0.0088635 11929000.0 150710.0 118292.0 143628.0 171380.0 157286.0 146241.0 172295.0 176340.0 161682.0 121856.0 False True 142334.1415399313 127364.61603127024 134387.13085034234 148037.7483530098 137526.32652531948 166384.37030637712 180307.0588960654 176853.12020534158 194022.91777253116 118337.70066008951 1.202779340362279 1.0762809765681474 1.1356239820507654 1.2509770557248703 1.1621514171578078 1.4060132094698694 1.5236653905755297 1.4944782534970018 1.6395697794554764 1.0 16.85255024287708 -6.8084777009468525 4.082752653984677 1.4567243675049535 1.1618357213780715 0.3530034484598439 0.1630979606083509 0.20481267030038552 7.1306790212662525 0.05553252615284403 0.05021950418070201 1.554255092676973e-07 6.8084777009468525 -0.29488864612688204 EALS(ph)PCPSTVSTK ddPTM_A459_Selumetinib_30min_R1 3 EALSPCPSTVSTK 13 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 EALS(0.998)PCPS(0.002)TVSTK;EALS(0.931)PCPS(0.019)T(0.05)VSTK;EALS(0.999)PCPS(0.001)TVSTK 175.15 0.00010491 61517000.0 6862.84 7725.62 8731.93 9243.470000000001 7437.66 6576.16 7082.8099999999995 6655.34 4367.99 6288.18 True False 7022.730819237961 6821.1008188567 7546.181867058179 7629.271485921585 6764.924966225525 6510.009801075546 6548.547939296954 6478.8187636089515 7412.160004632756 7095.329155060104 0.9897681510983365 0.9613508647434862 1.063542184181342 1.0752526513136735 0.9534335643049134 0.917506384666153 0.9229378646411057 0.9131103888236838 1.0446534392765556 1.0 12.792653897680545 -6.3706646907157625 9.36413365489035 0.9501613299232627 1.0209837070484915 0.28160050755114663 0.0488700550108202 0.46115125464704027 36.446457341211605 0.015790007863925315 0.017901228292429558 4.259271352564671e-07 6.3706646907157625 0.07082237712522876 EALS(ph)PCPSTVSTK ddPTM_A459_Selumetinib_30min_R2 1 EALSPCPSTVSTK 13 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 EALS(0.999)PCPS(0.001)TVSTK 119.17 0.003281 36041000.0 138890.0 109090.0 121150.0 141170.0 133180.0 95273.0 128460.0 127220.0 96754.0 125680.0 True False 131171.0498207223 117456.85222036405 113355.34089814681 121942.40246816675 116448.73775569355 108395.99094781552 134433.6445386609 127590.18913759508 116107.50353263516 122051.29184414397 1.0747207001153583 0.9623564850944233 0.9287516681339052 0.9991078392179882 0.954096724386951 0.8881183419691626 1.1014520412477802 1.0453817178807425 0.9513008979937807 1.0 16.89712803975069 -7.264472191224541 24.997638702163243 1.0283154682794184 0.9666258194511889 0.18857371559067349 0.057346225765883815 440.9409895916528 3634383.4682931923 0.023542808360641907 0.016620041297950056 5.439109583509381e-08 7.264472191224541 -0.06168964882822958 EALTYDGALLGDR ddPTM_A459_Selumetinib_30min_R2 1 EALTYDGALLGDR 13 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 158.3 0.0050507 4702600.0 24530.0 20116.0 20840.0 24229.0 30265.0 20941.0 21786.0 23079.0 21731.0 22135.0 False True 23166.720801370277 21658.83251686532 19499.17708887639 20928.968402643713 26462.840127467105 23825.432666528854 22799.092168140025 23146.156069065873 26077.807214871682 21495.905036363223 1.0777271653452434 1.0075794659599808 0.907111240763806 0.9736258309310327 1.2310642460832257 1.1083707629999724 1.0606249017927967 1.0767704839554804 1.213152326955183 1.0 14.391774232554361 -6.223719884028006 24.78673682009463 1.1157857448428077 0.9866300889956061 0.3944738043564381 0.07485020801256932 521.0428098694919 342394.417445921 0.02221961883459288 0.028684616567783858 5.974204931016176e-07 6.223719884028006 -0.12915565584720157 EANANGS(ph)SPEPVK ddPTM_A459_Selumetinib_30min_R1 3 EANANGSSPEPVK 13 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 EANANGS(0.5)S(0.5)PEPVK;EANANGS(0.5)S(0.5)PEPVK;EANANGS(0.773)S(0.227)PEPVK 165.78 0.00034913 147358000.0 23597.2 34337.3 28425.0 30906.2 28225.4 25767.6 29461.0 25985.5 14852.7 24106.300000000003 True False 24146.968847841705 30317.07295302231 24565.041127348548 25509.01235122628 25672.417553599123 25508.401339108874 27238.733050812825 25296.280127200174 25203.947101712416 27200.578420246467 0.8877373295072343 1.114574568401682 0.9031073070513757 0.9378113934606226 0.9438188099150909 0.9377889302575257 1.0014027139414785 0.9299905221269542 0.9265959977877574 1.0 14.731349710258462 EANANGS(ph)SPEPVK ddPTM_A459_Selumetinib_30min_R2 4 EANANGSSPEPVK 13 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 EANANGS(0.739)S(0.261)PEPVK;EANANGS(0.775)S(0.225)PEPVK;EANANGS(0.792)S(0.208)PEPVK;EANANGS(0.5)S(0.5)PEPVK 233.28 2.1095e-13 331279000.0 955887.0 930441.0 990080.0 1045720.0 1053400.0 820891.0 923678.0 898121.0 760896.0 923962.0 True False 902762.6272588435 1001802.8328606435 926379.3307175956 903291.1320323838 921062.4744845149 933961.2839434379 966630.8572332332 900734.3834180653 913096.4612105731 897284.816318418 1.0061048742169751 1.116482542266864 1.032425060437948 1.0066938786935122 1.0264995659501486 1.0408749451211092 1.0772843133569825 1.0038444505433637 1.0176216565850635 1.0 19.775206472812982 -11.435242875659732 0.07177258396277553 0.9006428132539412 1.099240354138543 0.1303707180295801 0.03313528970825471 281.17113771757903 2.8947001541711748 6.768253625348766 2.1808140446766497 3.670769582795677e-12 11.435242875659732 0.1985975408846017 EANANGSS(ph)PEPVKAVEAR ddPTM_A459_Selumetinib_30min_R1 2 EANANGSSPEPVKAVEAR 18 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 EANANGS(0.018)S(0.982)PEPVKAVEAR;EANANGS(0.017)S(0.983)PEPVKAVEAR 123.84 0.00048331 26013000.0 3820.1000000000004 2300.5 13681.5 12869.5 7655.9 5268.9 4236.1 4282.6 3278.6 2755.9 True False 3909.100897379353 2031.1563905265643 11823.62744710006 10622.083415434663 6963.425196758925 5215.899649778432 3916.567566496326 4169.011536154685 5563.544740530302 3109.6466097392467 1.2570884695181304 0.6531791696732006 3.8022415183992586 3.415849049267163 2.2392979237415114 1.6773287464377828 1.2594896005963656 1.340670519633184 1.7891244371966826 1.0 11.602534921820151 -6.856220641296391 3.438535724053478 1.3864644737494187 2.3358336943807156 0.19999092115361983 0.8746393068063755 0.45085196591147575 10.471353139892296 0.36166122521981625 0.3199010133217708 1.3924491958593274e-07 6.856220641296391 0.9493692206312969 EAPAEGEAAEPGS(ph)PTAAEGEAASAASSTSSPK ddPTM_A459_Selumetinib_30min_R2 2 EAPAEGEAAEPGSPTAAEGEAASAASSTSSPK 32 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 EAPAEGEAAEPGS(0.792)PT(0.208)AAEGEAASAASSTSSPK;EAPAEGEAAEPGS(0.841)PT(0.159)AAEGEAASAASSTSSPK 101.84 2.3534e-09 24415000.0 139331.0 132745.0 138298.0 153239.0 150485.0 102634.0 123576.0 131078.0 112934.0 163061.0 True False 131587.54080618513 142926.1146575509 129400.05724747757 132367.58384798057 131579.72894703073 116770.90188131043 129322.52886119846 131459.41527886892 135523.9556396076 158353.00524664196 0.8309759615943606 0.9025791107338761 0.817161992258569 0.8359019372054991 0.8309266296657228 0.7374088145623412 0.8166724001213161 0.8301668482648306 0.8558344404548743 1.0 17.272784721741566 -8.845266381184805 1.9559338923289624 0.9999527396783134 0.8247704425225616 0.6602584899557278 0.03745964352139902 1.0204741373811852 5.331456365934611 0.038819574840605296 0.010765319014396096 1.4280177932071921e-09 8.845266381184805 -0.17518229715575184 EAPATGPS(ph)PQHPQK ddPTM_A459_Selumetinib_30min_R2 1 EAPATGPSPQHPQK 14 0 Q9H0F6;H0YCU2 Q9H0F6 SHARPIN Sharpin 1 EAPAT(0.005)GPS(0.995)PQHPQK 103.01 0.0047546 2602800.0 23266.0 19300.0 24371.0 23916.0 23673.0 19154.0 21032.0 21498.0 17303.0 23450.0 True False 21972.968861177367 20780.24794071887 22802.99639313849 20658.599542598815 20698.98610069482 21792.28963729973 22010.029674117373 21560.555620814506 20764.08348621438 22772.937569582893 0.9648719579561831 0.9124974710541692 1.0013199361506941 0.9071556745578517 0.9089291198137659 0.9569380134079416 0.9664993638552581 0.9467621625420988 0.9117876612435069 1.0 14.475032781859234 EAPGS(ph)PPLSPR ddPTM_A459_Selumetinib_30min_R1 1 EAPGSPPLSPR 11 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;E9PNR0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 EAPGS(0.953)PPLS(0.047)PR 129.76 0.0025233 88312000.0 5874.9 6172.1 6943.4 6515.4 6077.1 5469.1 5617.3 5267.6 3026.3 4817.4 True False 6011.77373943456 5449.467662668555 6000.524417366124 5377.60769920533 5527.427377999147 5414.085819545487 5193.582538485826 5127.886136423764 5135.410067793221 5435.760215449706 1.1059674270302962 1.0025217166827722 1.1038979240311642 0.9893018613883864 1.0168637244683645 0.9960126284006023 0.9554473215585275 0.9433613575979874 0.9447455119887703 1.0 12.408266101398091 -6.326343742786752 0.8120200877887643 0.9555621262764423 1.0699533689505578 0.583676623699056 0.03554815272443689 0.4524310692775432 0.6494954634526867 0.018863532229417276 0.029603162202776468 4.7168955260186283e-07 6.326343742786752 0.11439124267411549 EAPGS(ph)PPLSPR ddPTM_A459_Selumetinib_30min_R2 3 EAPGSPPLSPR 11 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;E9PNR0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 EAPGS(0.962)PPLS(0.038)PR;EAPGS(0.971)PPLS(0.029)PR;EAPGS(0.999)PPLS(0.001)PR 124.47 0.0035638000000000006 91210000.0 223162.0 250351.0 277750.0 252636.0 272057.0 239435.0 218056.0 211441.0 177293.0 253287.0 True False 210759.54942826688 269552.11669465894 259879.8673913347 218226.54097859198 237878.76743956094 272414.9978754756 228196.0360697671 212056.2583040582 212756.55398031548 245973.94619134095 0.8568368833027499 1.0958563736867348 1.0565341224764369 0.8871937225775753 0.9670892837346162 1.1074953347439749 0.927724417984722 0.8621086159226861 0.8649556478425323 1.0 17.9081459863788 -7.508003512339744 24.30228057777728 0.8971025598789961 0.9981212714821127 0.18120920576401212 0.08426266316874259 700.3427270262657 1144186.2057527667 0.0362025097545349 0.023430703981592974 3.104534480224869e-08 7.508003512339744 0.1010187116031166 EAPGSPPLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 EAPGSPPLSPR 11 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;E9PNR0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 EAPGSPPLS(1)PR;EAPGS(0.165)PPLS(0.835)PR 148.78 0.00064275 95629700.0 8919.7 10016.099999999999 10105.6 10702.300000000001 9576.9 8485.6 9392.1 7262.6 5318.07 6553.76 True False 9127.511655285107 8843.41035564144 8733.31502608737 8833.344212052249 8710.671085939022 8400.242568308346 8683.646335376905 7069.972255750479 9024.376373535035 7394.998935028369 1.234281672719415 1.1958636415418922 1.180975832832066 1.1945024319355582 1.177913771519104 1.1359356021700524 1.1742593084421578 0.9560477719965158 1.2203350470800867 1.0 12.852334224220453 -6.958213278060146 0.10397102996875661 0.8624350330752617 1.4267667885800084 0.44754832709938486 0.06593257962484175 16.13115981424157 0.8131596264563153 1.621879985473397 2.5535012457301054 1.1009984864379004e-07 6.958213278060146 0.5643317555047467 EAPPMEKPEVVK ddPTM_A459_Selumetinib_30min_R2 1 EAPPMEKPEVVK 12 1 K7EM56;A0A0B4J2B4;S4R417;K7EQJ5;K7ELC2;P62841;S4R456;K7EJ78 K7EM56 RPS15 40S ribosomal protein S15 0 97.452 0.045621 5724700.0 36182.0 24780.0 27599.0 28171.0 33742.0 25097.0 20517.0 23363.0 18894.0 32367.0 False True 34171.149288021996 26680.54631974164 25823.310387519174 24334.061202314424 29503.02830269271 28553.88394211712 21471.08115366424 23430.982462047148 22673.327942468615 31432.480610434526 1.0871286205988566 0.8488208948702762 0.8215485983294205 0.7741692901652927 0.9386159707961037 0.9084196788667769 0.6830857996787107 0.7454385402299063 0.7213343491236206 1.0 14.93996851179279 -7.241296244348347 24.40050190032617 0.7662512096085119 0.887239277222083 0.17255465890470922 0.11208285611477677 942.4617250654051 1141657.5382414288 0.04214132195162775 0.03259764666991179 5.737249749336736e-08 7.241296244348347 0.12098806761357106 EAPPPVLLT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EAPPPVLLTPK 11 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 EAPPPVLLT(1)PK;EAPPPVLLT(1)PK 112.43 0.017953 9185400.0 5896.3 6209.3 7285.6 7349.1 5618.1 5888.0 5855.9 5672.4 3213.7 5030.9 True False 6033.672317797409 5482.312269374745 6296.255536936174 6065.717644692552 5109.943846956116 5828.772065876254 5414.184748387861 5521.9495254480535 5453.4141806387515 5676.665020115818 1.0628903231768125 0.9657628642781694 1.1091469224667612 1.0685354205679019 0.9001665289124037 1.0267951420810333 0.9537615359021833 0.9727453541613755 0.9606721836349414 1.0 12.470827895382431 -6.235372500858056 24.97546727524443 0.9697862042568172 1.0495654625530242 0.44390454126889045 0.04524228704799969 738.5067721267076 707585.8994482082 0.013070597543792984 0.01686909517031166 5.816041532124836e-07 6.235372500858056 0.07977925829620702 EAPPPVLLT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EAPPPVLLTPK 11 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 EAPPPVLLT(1)PK 109.6 0.021757 3962400.0 74418.0 79141.0 84848.0 76057.0 85842.0 65684.0 63166.0 64293.0 59295.0 69860.0 True False 70282.14547885743 85210.86022157686 79388.9720555175 65697.9053943568 75057.7605227832 74731.37478001438 66103.34416105451 64480.08198572089 71155.6568407259 67842.9602819217 1.0359534016027558 1.2560015050564242 1.1701873226878117 0.9683820564631744 1.1063455988783562 1.1015346982128704 0.9743581926018823 0.9504314333834144 1.0488288916792292 1.0 16.049911501851362 -6.324958495006614 0.6975255131437827 0.9927853929379928 1.1608901142790142 0.32322125836776083 0.07649157975391914 0.9035210846688262 0.9554139147688848 0.05022992801161296 0.08477532884339906 4.731964796104146e-07 6.324958495006614 0.1681047213410214 EAPS(ph)PTCPDLGAK ddPTM_A459_Selumetinib_30min_R1 1 EAPSPTCPDLGAK 13 0 O00257 O00257 CBX4 E3 SUMO-protein ligase CBX4 1 EAPS(0.991)PT(0.009)CPDLGAK 149.82 0.00050901 11500000.0 2734.2 4089.5 4107.0 4197.6 3976.4 3890.2 4159.7 3283.0 1761.6 3002.1 True False 2797.9015401729334 3610.699438843027 3549.291958136168 3464.567958710793 3616.7353220904383 3851.0681200189915 3845.930480006319 3195.9241753130877 2989.306537826563 3387.4487779303313 0.8259612834300626 1.0659052506910813 1.047777306998785 1.0227661540693702 1.0676870881868203 1.1368638679082619 1.13534719847664 0.9434605169928911 0.882465458164942 1.0 11.725983416107312 -7.8919508858424505 9.131722345129837 0.9319747350739618 1.0478945554514556 0.2242823777950751 0.08558805429902204 0.376258004709612 28.97250683542425 0.047710649097807215 0.022871744762463862 1.2824756090154348e-08 7.8919508858424505 0.11591982037749382 EAPS(ph)PTLR ddPTM_A459_Selumetinib_30min_R1 1 EAPSPTLR 8 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 EAPS(0.998)PT(0.002)LR 166.34 0.00025385 30826000.0 4598.4 5787.1 4783.7 5034.2 5098.0 3862.9 4820.0 4384.2 2615.7 4037.3 True False 4705.533773071182 5109.543641650201 4134.099814983193 4155.071473637759 4636.886800125001 3824.0427332325717 4456.423519395739 4267.916774111371 4438.651856830691 4555.526781632231 1.0329285719587413 1.1216142252201768 0.9074910571597952 0.9120946210635621 1.017859629059983 0.8394293166382021 0.9782454879562834 0.9368656971394621 0.9743443666552951 1.0 12.153402175419608 -5.263907009836773 24.984225079985844 0.9422673299303803 1.077271402423401 0.49579106836241493 0.05294130327450846 149.0519589399346 1509134.2623813078 0.012980043753632455 0.029219137916182854 5.446192530153836e-06 5.263907009836773 0.1350040724930206 EAPS(ph)PTLR ddPTM_A459_Selumetinib_30min_R2 2 EAPSPTLR 8 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 EAPS(0.993)PT(0.007)LR;EAPS(0.989)PT(0.011)LR 131.12 0.0036497 89689000.0 448610.0 362800.0 387610.0 499130.0 466530.0 369420.0 385740.0 418260.0 375520.0 402960.0 True False 423678.052128117 390625.5934141352 362671.5945978594 431147.632952724 407920.33056888235 420304.25173912843 403677.6743293097 419477.0673533291 450634.4929054624 391325.4977841846 1.08267428145399 0.9982114521695814 0.9267773162020541 1.1017621785291927 1.0424067250375026 1.0740528131160152 1.0315649673099945 1.0719390117141563 1.1515592402158947 1.0 18.578009590114682 -5.787368688565722 24.999990131209156 1.0683257605177117 1.0021199367003302 0.24782656638645228 0.05192690611138473 297.53300745716865 286868.2678245918 0.014530202050480166 0.021560337355421847 1.63166617830561e-06 5.787368688565722 -0.06620582381738149 EAPS(ph)PTLRR ddPTM_A459_Selumetinib_30min_R1 1 EAPSPTLRR 9 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 EAPS(0.968)PT(0.032)LRR 76.165 0.029385 12819000.0 941.49 933.88 1318.2 1255.2 1374.7 925.69 1106.7 907.86 654.92 1063.2 True False 963.424885179364 824.5408954509662 1139.1956803542964 1036.0028830221513 1250.3586277229972 916.3783990592718 1023.2207279907179 883.7806036551143 1111.3514065357476 1199.6720764449974 0.8030735265876092 0.6873052325218222 0.9495892275246487 0.8635717237765098 1.0422503384659914 0.7638574049125049 0.8529170163090235 0.7366851500570322 0.9263793234473111 1.0 10.228424391879681 EAPS(ph)PTLRR ddPTM_A459_Selumetinib_30min_R2 2 EAPSPTLRR 9 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 EAPS(0.994)PT(0.006)LRR;EAPS(0.97)PT(0.03)LRR 76.165 0.029385 64036000.0 138025.0 143857.0 142687.0 167098.0 160478.0 121113.0 111269.0 111067.0 97883.0 138877.0 True False 130354.12305785304 154890.3693268391 133506.6737658588 144338.96413987217 140317.3189484773 137795.21639565023 116443.22897534064 111390.18658186821 117462.33507953072 134867.2601642204 0.9665364514644105 1.1484653068375354 0.9899116627956638 1.070229824229532 1.0404105397975807 1.0217099111219774 0.8633913733663319 0.8259245901950891 0.8709477373270824 1.0 17.041180642356984 -7.206086571132065 4.534864063243482 0.8751126290514367 1.0456532057378045 0.5757111585975911 0.06241624269440308 0.13450526462191784 5.885009598197896 0.02344842819893963 0.01756794748237378 6.221762498122825e-08 7.206086571132065 0.1705405766863678 EAPSPLMIHS(ph)PQMSQFQSLT(ph)HQSPPQQNVQPK ddPTM_A459_Selumetinib_30min_R2 1 EAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPK 32 0 O60885 O60885 BRD4 Bromodomain-containing protein 4 2 EAPS(0.065)PLMIHS(0.914)PQMS(0.077)QFQS(0.106)LT(0.419)HQS(0.419)PPQQNVQPK 60.95 0.0016756 4756200.0 4882.0 3145.6 6664.2 8664.1 9937.5 5202.1 4628.1 3328.1 4253.7 7570.3 True False 4610.67798419444 3386.857405301829 6235.432627432338 7484.034633593844 8689.062407622809 5918.642055037956 4843.315820406172 3337.7842200033856 5104.558858308394 7351.725768998436 0.62715587184131 0.4606887568608586 0.8481590341313593 1.0179969804033417 1.1819078513869221 0.8050683936003619 0.6587998481703435 0.45401370030401844 0.6943347750855803 1.0 12.84386723748534 -10.674045614816393 3.960891444346336 1.0001025977029199 0.7550297117781226 0.10681176127927916 0.21658640048448294 96600113.325033 164267320.31077352 126153.08066021198 0.06187595753310494 2.1181386512338714e-11 10.674045614816393 -0.24507288592479726 EAQAVPATLPELEATK ddPTM_A459_Selumetinib_30min_R2 1 EAQAVPATLPELEATK 16 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 129.54 0.0077765 0.0 9532.7 6731.9 7314.8 9458.6 9793.3 9338.5 7665.7 7586.0 7133.3 10042.0 False True 9002.91069642162 7248.215083529808 6844.173731752063 8170.3223630049015 8562.978100787166 10624.793608537306 8022.1702392963825 7608.074004070098 8560.15932105491 9752.061367750597 0.9231802751153344 0.743249535682698 0.7018181565576771 0.83780465020694 0.8780685208877327 1.089492078431005 0.8226127724980437 0.7801503412631796 0.8777794763846314 1.0 13.251491489236997 -6.123330193053902 3.5242036795579414 0.9016880901324016 0.7835427214172849 0.22776560056377126 0.09766842075962724 0.3966603656604978 8.995000947093903 0.03133138443971023 0.04210700862526553 7.527830069881995e-07 6.123330193053902 -0.11814536871511672 EAQQKVPDEEENEES(ph)DNEK ddPTM_A459_Selumetinib_30min_R1 1 EAQQKVPDEEENEESDNEK 19 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 EAQQKVPDEEENEES(1)DNEK 73.389 0.0061844 3379600.0 869.77 874.83 800.01 929.83 759.18 860.94 1018.7 752.94 484.83 693.88 True False 890.0339487221909 772.4044969025672 691.373036140374 767.452645570815 690.512303044115 852.2797252709755 941.8586388399252 732.9695853061942 822.721099417832 782.9462569635583 1.1367752777488747 0.986535780754768 0.8830402214599941 0.9802111431596454 0.8819408700184315 1.088554568964041 1.202967164684668 0.9361684519047515 1.0508014976769025 1.0 9.612769471143952 -6.789005739238297 24.968089884378262 1.0609131867408321 0.9697386544768404 0.1652350595746791 0.09156169512782787 383.32897814841755 347195.508750508 0.03323521815029197 0.029317452425187754 1.625527274128182e-07 6.789005739238297 -0.09117453226399175 EAQQKVPDEEENEES(ph)DNEKETEK ddPTM_A459_Selumetinib_30min_R1 2 EAQQKVPDEEENEESDNEKETEK 23 2 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 EAQQKVPDEEENEES(0.974)DNEKET(0.026)EK;EAQQKVPDEEENEES(0.984)DNEKET(0.016)EK 68.134 0.001298 207478000.0 4598.4 6830.1 7370.8 8249.0 4640.8 6805.0 5280.6 5904.700000000001 3287.8 4762.9 True False 4705.533773071182 6030.428716772653 6369.885844906275 6808.467002907691 4221.040459399789 6736.547878445642 4882.280090564552 5748.088174831308 5579.156468588887 5374.264609574752 0.8755679362508194 1.122093747678312 1.1852572040382476 1.2668648638509115 0.7854173112130751 1.2534827307244707 0.9084554716316565 1.0695580869967873 1.0381246317215385 1.0 12.391851640907674 -6.2148844411714474 24.99845438922833 1.0198296276572523 1.1183357432795313 0.10524613879524813 0.14513365833312752 1054.211115768135 566075.7911186399 0.04171493588158437 0.0538534642931981 6.096991068576088e-07 6.2148844411714474 0.09850611562227907 EAQQKVPDEEENEES(ph)DNEKETEK ddPTM_A459_Selumetinib_30min_R2 4 EAQQKVPDEEENEESDNEKETEK 23 2 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 EAQQKVPDEEENEES(0.999)DNEKET(0.001)EK;EAQQKVPDEEENEES(1)DNEKETEK;EAQQKVPDEEENEES(0.998)DNEKET(0.002)EK;EAQQKVPDEEENEES(0.999)DNEKET(0.001)EK 103.31 3.3691e-05 248354000.0 208630.0 229089.0 223008.0 181022.0 168387.0 122453.0 144512.0 154817.0 102099.0 232823.0 True False 197035.17981206178 246659.3896627645 208659.90807275215 156366.4913196323 147232.71966112012 139319.7892323414 151232.09434509536 155267.49183866594 122521.65288441347 226100.79504319833 0.8714484165100642 1.090926679915647 0.9228623368302886 0.6915786885656783 0.6511817865699683 0.6161844287443715 0.6688702457512424 0.6867180268384322 0.5418895270182696 1.0 17.786606539515475 -5.717765942979402 3.828494403982824 0.6726973352054955 0.9863062686361336 0.4953949162193473 0.12354949652723039 0.1529614422589083 4.651473012986931 0.03215691822755815 0.05623680485553134 1.915287864897566e-06 5.717765942979402 0.3136089334306381 EAQSFISAAIEPES(ph)GKSNER ddPTM_A459_Selumetinib_30min_R1 1 EAQSFISAAIEPESGKSNER 20 1 Q8WXA9;Q8WXA9-2 Q8WXA9 SREK1 Splicing regulatory glutamine/lysine-rich protein 1 1 EAQSFISAAIEPES(0.766)GKS(0.234)NER 153.65 3.1369e-06 7384600.0 1042.4 1586.1 1364.9 1401.8 1283.3 1286.4 1320.7 1189.9 665.48 1132.9 True False 1066.6858918426847 1400.398674642114 1179.5540768590338 1157.001945044975 1167.2257415850174 1273.4599839577475 1221.0785356983295 1158.33998666008 1129.2709552638642 1278.3187503804902 0.8344443758844864 1.0955003783096249 0.9227386178196485 0.9050965924583322 0.913094438486171 0.9961990963354824 0.9552222677910942 0.9061433123118169 0.883403263018506 1.0 10.320031903619268 EAQSFISAAIEPES(ph)GKSNER ddPTM_A459_Selumetinib_30min_R2 1 EAQSFISAAIEPESGKSNER 20 1 Q8WXA9;Q8WXA9-2 Q8WXA9 SREK1 Splicing regulatory glutamine/lysine-rich protein 1 1 EAQSFISAAIEPES(0.5)GKS(0.5)NER 115.77 0.00014825 3207800.0 20909.0 20419.0 23071.0 24173.0 20060.0 18084.0 16201.0 15686.0 16233.0 19266.0 True False 19746.961485358792 21985.071642566778 21586.63697780553 20880.595699249097 17539.883461324644 20574.906849792646 16954.378601672484 15731.643663042907 19480.053587916438 18709.740520920437 1.0554374852648853 1.175060210909072 1.153764636856843 1.1160280751035163 0.9374733680412238 1.099689588254132 0.9061792483286883 0.840826394436227 1.041171766446182 1.0 14.19150193001606 -6.337763434311967 1.3879170099395879 0.9529483530346642 1.1386804413073914 0.4741150434367618 0.07602397238980305 0.3481943362401391 1.3569487651960426 0.030186529259641607 0.03947439599239796 4.5944821192976903e-07 6.337763434311967 0.18573208827272725 EAQSSQATPVQTSQPDSS(ph)NIVKVSPR ddPTM_A459_Selumetinib_30min_R2 2 EAQSSQATPVQTSQPDSSNIVKVSPR 26 1 H7C5E4;Q8IZH2-2;Q8IZH2 H7C5E4 XRN1 5-3 exoribonuclease 1 1 EAQSSQAT(0.078)PVQT(0.042)S(0.042)QPDS(0.264)S(0.347)NIVKVS(0.226)PR;EAQSSQATPVQTSQPDS(0.343)S(0.448)NIVKVS(0.208)PR 65.428 0.00090138 14935300.0 41834.0 41575.0 48125.0 48654.0 47748.0 39222.0 36747.4 37157.4 31018.6 45678.0 True False 39509.03375477065 44763.66881530504 45028.68989453819 42027.241267168574 41749.46936746405 44624.474478133576 38456.22691359172 37265.52188226128 37223.18673209785 44359.15745430312 0.8906624025821759 1.0091190046027956 1.0150934435786974 0.9474310081399363 0.9411691241086476 1.005981110531772 0.8669287047033674 0.8400863321322234 0.8391319598539166 1.0 15.43694434315452 -7.272652592536431 24.497397238202858 0.8732105995830544 0.9700536753695416 0.3312821353216421 0.055559090376362474 559.1204807890601 1221499.8398700538 0.022324444918680734 0.015214192021663409 5.33761699553923e-08 7.272652592536431 0.09684307578648721 EAQTLDSQIQETS(ph)I ddPTM_A459_Selumetinib_30min_R2 1 EAQTLDSQIQETSI 14 0 E7EVA0;P27816-4;P27816;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 EAQTLDSQIQET(0.206)S(0.794)I 185.32 7.918399999999999e-05 3938000.0 62271.0 57117.0 63853.0 66590.0 71396.0 55079.0 55104.0 65645.0 52226.0 60094.0 True False 58810.22711056372 61497.690239898446 59744.767497889785 57520.327125842705 62426.59619166178 62665.63229261944 57666.44518650453 65836.01608188519 62672.659316363184 58358.93007703689 1.0077331272682877 1.053783716711705 1.0237467928048631 0.9856302548712392 1.0697008342897196 1.0737967987058274 0.9881340372481426 1.1281223969489869 1.073917209133751 1.0 15.832665813410078 -6.288300430770891 24.66293363992951 1.059553355423835 1.0207294321310911 0.16849466086059095 0.04045213194102531 1122.2485917741878 1030408.4645992784 0.012513820040594776 0.01419257239064579 5.14872349445293e-07 6.288300430770891 -0.03882392329274387 EARNS(ph)WDSPAFSNDVIR ddPTM_A459_Selumetinib_30min_R1 2 EARNSWDSPAFSNDVIR 17 1 A0A0C4DGT3;A0A3B3IU98;A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2;A0A2R8Y695 A0A0C4DGT3;A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 EARNS(1)WDSPAFSNDVIR;EARNS(0.994)WDS(0.006)PAFSNDVIR 139.78 0.00027803 14551600.0 2300.1000000000004 2123.8999999999996 6355.1 5627.5 3940.2 3603.3 2681.7 2205.19 2039.17 1530.2800000000002 True False 2353.6878547844944 1875.2328006256785 5492.112326065537 4644.762766258093 3583.8096056988115 3567.0540735346335 2479.4172099509433 2146.7011977333736 3460.322554915871 1726.7063441894757 1.3631083610162602 1.086017206652427 3.180686944567613 2.6899552329138903 2.0755177148440196 2.0658139616722297 1.4359229166525092 1.2432346733173356 2.0040017612491967 1.0 10.75380703353676 -7.246913066956816 5.525447873400433 1.4382050430809301 2.1127431197580613 0.21968640520723481 0.6035060576051754 0.3028682528346896 33.00330621771413 0.2630514541838296 0.19264791073319948 5.663526449145974e-08 7.246913066956816 0.6745380766771312 EAS(ph)AESDVGK ddPTM_A459_Selumetinib_30min_R2 1 EASAESDVGK 10 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 EAS(0.979)AES(0.021)DVGK 100.04 0.014729 0.0 21908.0 22903.0 19553.0 23863.0 16189.0 11596.0 11878.0 15724.0 18172.0 21770.0 True False 20690.441064672646 24659.586455247896 18294.981267696738 20612.81823402893 14155.193088503718 13193.243741992683 12430.350535810483 15769.754236751663 21806.90776810309 21141.443534747104 0.9786673757951669 1.1664097777769307 0.8653610259691089 0.9749957802148491 0.6695471416244068 0.6240464952314573 0.5879612958017995 0.7459166263095148 1.031476764217271 1.0 14.367786266644702 -5.845237045605438 1.7232168418349578 0.7516710262930131 1.0519633068886922 0.30229373385108227 0.15604367040459705 0.39582470739286724 2.3974573289394776 0.05124420477554717 0.09894346984671458 1.4281142557364954e-06 5.845237045605438 0.30029228059567914 EAS(ph)PAPLAQGEPGR ddPTM_A459_Selumetinib_30min_R1 2 EASPAPLAQGEPGR 14 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 EAS(1)PAPLAQGEPGR;EAS(1)PAPLAQGEPGR 220.25 7.984799999999999e-09 32795000.0 3783.8 4537.2 3028.3 2745.8 3340.8999999999996 3152.3 3603.5 4011.8 2244.67 3779.0 True False 3871.9551780068573 4005.9825147129436 2617.0734932612027 2266.2975750495743 3038.7161848838 3120.5907240593974 3331.6850938055068 3905.3940318370524 3809.0410457897096 4264.071460577165 0.9080418125738369 0.9394735880366114 0.6137499142443938 0.5314867717397068 0.7126325656072595 0.7318335897768956 0.781338944388738 0.9158838138487566 0.893287338405472 1.0 12.05801590075083 -7.755259112148351 1.8778196026325862 0.9496022336714836 0.7312504982519638 0.3682751204120005 0.11588909812171698 0.4447805054688567 3.042864864058683 0.09560527761267713 0.038926062659501784 1.7568751007298615e-08 7.755259112148351 -0.2183517354195198 EAS(ph)PAPLAQGEPGR ddPTM_A459_Selumetinib_30min_R2 4 EASPAPLAQGEPGR 14 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 EAS(1)PAPLAQGEPGR;EAS(1)PAPLAQGEPGR;EAS(1)PAPLAQGEPGR;EAS(1)PAPLAQGEPGR 182.7 7.6255e-05 84733000.0 87457.0 67175.0 83718.0 88267.0 102417.0 84954.0 95932.0 95065.0 91549.0 79657.0 True False 82596.49005811002 72327.106498331 78331.6750252666 76244.88233093197 89550.46084040318 96655.64236437099 100393.02808565185 95341.62341114202 109861.35809278396 77357.0954362587 1.0677299812293044 0.9349770191142667 1.0125984511635513 0.985622351782285 1.157624395478908 1.249473520422106 1.2977869388642502 1.2324871154153187 1.420184631716277 1.0 16.239246005822658 -6.453797483589229 2.5168085740259736 1.2585261495719078 0.9945406965606861 0.5447387852749879 0.10254964779987391 0.1976636756899272 2.471997153280725 0.03329437914942336 0.03724859644041702 3.517244153519679e-07 6.453797483589229 -0.26398545301122167 EAS(ph)PAPLAQGEPGREDLPTR ddPTM_A459_Selumetinib_30min_R1 1 EASPAPLAQGEPGREDLPTR 20 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 EAS(1)PAPLAQGEPGREDLPTR 98.76 0.00047219 124640000.0 2998.3 3758.7 2274.8 3020.7 2888.6 2956.1 3654.9 3078.9 1584.3 3425.5 True False 3068.154556323793 3318.6296566277783 1965.8946545819715 2493.191450561675 2627.32664002375 2926.3643179240503 3379.2079504231283 2997.237570323321 2688.441387306214 3865.1962921955774 0.7937901012993483 0.858592786950717 0.5086144417946932 0.6450361798172605 0.6797395116332705 0.7571062623217423 0.8742655469390432 0.775442524452174 0.6955510623702574 1.0 11.916325967269175 -6.97803801759195 4.398524760539023 0.8180006065478628 0.6936319262087903 0.24597735742214366 0.11280413218133105 0.34631332595919523 16.084845260647068 0.0437169256565486 0.03685696522626369 1.0518697904362301e-07 6.97803801759195 -0.12436868033907245 EAS(ph)PAPLAQGEPGREDLPTR ddPTM_A459_Selumetinib_30min_R2 1 EASPAPLAQGEPGREDLPTR 20 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 EAS(1)PAPLAQGEPGREDLPTR 101.54 0.0032947 24632000.0 19608.0 16162.0 18527.0 17459.0 21286.0 13587.0 20671.0 18825.0 18977.0 18392.0 True False 18518.265857043138 17401.57343097919 17334.9929906724 15081.054081545104 18611.86238074557 15458.485919494178 21632.242458809444 18879.77763335349 22772.930261682384 17860.975171845144 1.0368003806552568 0.9742790224808037 0.9705513178249153 0.8443578212525527 1.0420406613679232 0.8654894691227112 1.2111456541806898 1.0570406963621066 1.2750104651385508 1.0 14.124523230287313 -7.265201630062158 24.999677954405612 1.1405525971257076 0.9559902195692392 0.4782750681518343 0.09215488598215033 274.5938759437505 1824627.1194353926 0.03505831947724604 0.024674828046470924 5.429981749960064e-08 7.265201630062158 -0.18456237755646832 EAS(ph)PLGSSVEPGTEEK ddPTM_A459_Selumetinib_30min_R2 2 EASPLGSSVEPGTEEK 16 0 A0A0J9YW69;A0A0J9YY72;A0A1W2PQQ1;Q5HYW2 A0A0J9YW69 NHSL2 NHS-like protein 2 1 EAS(0.997)PLGS(0.002)SVEPGTEEK;EAS(1)PLGSSVEPGTEEK 175.27 1.4787e-06 7603600.0 69266.0 51157.0 54586.0 47923.0 57055.0 44272.0 56588.0 49507.0 36504.0 47187.0 True False 65416.473013767325 55080.57740431892 51073.996188743135 41395.804728213916 49887.240821828396 50370.06613879786 59219.45412699475 49651.05717367494 43805.820006979724 45824.58870345025 1.427540865387886 1.2019873819439597 1.114554383003063 0.903353546631988 1.088656597545681 1.0991929783541161 1.2923073791284452 1.0835025164107275 0.9559457323330317 1.0 15.4838343115278 -4.824707044090135 2.016422429017776 1.0742079016973698 1.5089941301937269 0.5564569141097353 0.09921044361061553 0.547621257177549 2.6579214975511727 0.028616383330803206 0.432117448165893 1.4972452911898164e-05 4.824707044090135 0.43478622849635706 EAS(ph)PSTLNDK ddPTM_A459_Selumetinib_30min_R1 1 EASPSTLNDK 10 0 P54253 P54253 ATXN1 Ataxin-1 1 EAS(0.997)PS(0.003)TLNDK 191.33 0.00017799 6543000.0 3090.2 3800.9 4207.8 4055.3 3692.3 3001.4 3310.2 3433.5 1802.0 2634.7 True False 3162.1956475175193 3355.88886100953 3636.4038717909343 3347.1179824089663 3358.33211692851 2971.208641053157 3060.5089489426914 3342.432426420189 3057.8623871273085 2972.8894091512734 1.0636775245602865 1.1288307095041248 1.2231884107754574 1.1258804219577516 1.1296525550498955 0.9994346348394452 1.0294728554387875 1.1243043270063706 1.0285826232602087 1.0 11.537650080959585 -6.6744867868961535 7.23568476017586 1.0438978341734761 1.1392706145825027 0.4967603530859185 0.048888204436855966 0.21350603875978877 15.068931256946577 0.01687328807944171 0.01682830902833798 2.1159880617086507e-07 6.6744867868961535 0.09537278040902653 EAS(ph)RSSPVEFECINEK ddPTM_A459_Selumetinib_30min_R1 1 EASRSSPVEFECINEK 16 1 O75131;H0YB26 O75131 CPNE3 Copine-3 1 EAS(0.333)RS(0.333)S(0.333)PVEFECINEK 75.02 0.017327000000000002 5434700.0 1726.4 2020.9 2267.9 2981.5 2825.9 2724.5 2628.4 2745.1 1616.1 1717.2 True False 1766.6217610103702 1784.2920885090796 1959.9316366829837 2460.8369946865414 2570.297843953167 2697.094003648075 2430.137671863019 2672.2910306585295 2742.403664726109 1937.6193469444593 0.9117486175993521 0.9208682248775178 1.0115153111851973 1.2700311846943382 1.32652362705111 1.3919627753001507 1.254187348869756 1.379162029359696 1.415346966395004 1.0 10.92006946005133 -5.710805893534356 2.655726624516381 1.316716089721146 0.9197083581178432 0.6689501278231085 0.11131484964887677 0.1417134989019854 2.0281779510281344 0.030427657371809764 0.057122147913566866 1.946229748135237e-06 5.710805893534356 -0.3970077316033028 EAS(ph)RSSPVEFECINEK ddPTM_A459_Selumetinib_30min_R2 1 EASRSSPVEFECINEK 16 1 O75131;H0YB26 O75131 CPNE3 Copine-3 1 EAS(0.602)RS(0.199)S(0.199)PVEFECINEK 60.631 0.03967 2563700.0 8003.1 11431.0 16781.0 17278.0 18222.0 8136.8 6112.1 7290.5 7053.7 10509.0 True False 7558.319740947672 12307.720943541834 15701.328729771334 14924.706593787518 15932.789453253114 9257.570341483794 6396.324760896385 7311.7141479927495 8464.637096845077 10205.577864338875 0.7406067389244603 1.2059798187958009 1.5385046234996786 1.4624068124489638 1.561184448842109 0.9071088834501294 0.6267479260774562 0.7164429339706389 0.8294128181043889 1.0 13.317070253092352 -6.91624471336504 6.010014598989685 0.7690724316953019 1.316370323568007 0.5174601804772423 0.2356983665792349 0.16891289065436066 9.559849200346038 0.08900832011809573 0.07830921939029979 1.212705330779572e-07 6.91624471336504 0.5472978918727052 EASPS(ph)TLNDK ddPTM_A459_Selumetinib_30min_R1 1 EASPSTLNDK 10 0 P54253 P54253 ATXN1 Ataxin-1 1 EAS(0.086)PS(0.659)T(0.254)LNDK 164.81 0.00036923 7121200.0 3321.0 4012.1 4242.3 4360.6 4041.6 3444.5 3653.5 3284.3 2158.2 3394.8 True False 3398.3728384588962 3542.361466825311 3666.2189612858674 3599.1030685997403 3676.0379936024337 3409.8514573557673 3377.9135535502733 3197.189695090092 3662.3077713086354 3830.555648152254 0.8871749037501048 0.9247643924802503 0.9570984729211133 0.9395772830857686 0.959661817046215 0.8901714974433482 0.8818338287761668 0.8346542874614864 0.9560774226254156 1.0 11.903337964720915 -6.777321363400038 24.98044636410387 0.9002936980127014 0.934792823820287 0.016458322099924705 0.046164777474730086 540.3634359775824 849920.4734718301 0.015813551433454334 0.013988073801953646 1.6698545205038415e-07 6.777321363400038 0.03449912580758563 EASQTS(ph)SSPAPK ddPTM_A459_Selumetinib_30min_R2 1 EASQTSSSPAPK 12 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 EAS(0.004)QT(0.093)S(0.784)S(0.046)S(0.073)PAPK 118.24 0.0045701 12211000.0 79119.0 63171.0 62744.0 80708.0 78521.0 74399.0 113350.0 187530.0 83809.0 151860.0 True False 74721.88271845154 68016.01257322017 58707.119350501904 69715.43117093423 68656.4899933536 84646.78692312114 118620.99959876404 188075.68125273733 100573.14181911455 147475.40722033492 0.5066735134137563 0.46120240557533215 0.39808074076236194 0.4727258088989456 0.46554534947496506 0.5739722203082648 0.8043442756631206 1.2753019964321493 0.68196551353714 1.0 17.170114867288333 -7.3009956117426285 2.6142697000360937 0.990175066613547 0.46356175958158624 0.7332266353687198 0.1392899137106901 0.13481904406564119 1.818697892345025 0.06146559477061115 0.039904598970515626 5.0003958751946176e-08 7.3009956117426285 -0.5266133070319607 EASQTSSS(ph)PAPK ddPTM_A459_Selumetinib_30min_R1 3 EASQTSSSPAPK 12 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 EASQTSS(0.013)S(0.987)PAPK;EASQT(0.006)S(0.006)S(0.087)S(0.901)PAPK;EASQTSS(0.009)S(0.991)PAPK 193.45 0.00010361 102068200.0 25265.6 31924.8 33465.5 32084.2 29802.2 30491.5 27729.5 29981.0 20253.9 24450.6 True False 25854.239321700436 28187.029574563137 28921.068912833187 26481.296765024956 27106.59627200577 30184.783194066902 25637.841489851464 29185.806487987087 34369.389013672495 27589.072679012446 0.9371188231842337 1.0216736859012143 1.0482798479426247 0.9598472943662874 0.9825120469752611 1.0940847322146157 0.9292752166097513 1.0578755881921797 1.2457609363513682 1.0 14.75180934534272 -8.004558713361307 24.950228926211196 1.1325264100568742 1.0004258267489008 0.3267947938631882 0.07275746254749679 180.58121868906034 988330.934335567 0.03830781082589056 0.017669005307273132 9.895580739852985e-09 8.004558713361307 -0.13210058330797336 EASQTSSS(ph)PAPK ddPTM_A459_Selumetinib_30min_R2 3 EASQTSSSPAPK 12 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 EASQT(0.002)S(0.038)S(0.092)S(0.868)PAPK;EASQT(0.027)S(0.074)S(0.074)S(0.824)PAPK;EASQTSS(0.052)S(0.947)PAPK 166.45 0.00046998 55153000.0 157463.0 121750.0 133885.0 154338.0 166380.0 136889.0 219250.0 327857.0 183033.0 261103.0 True False 148711.83683433212 131087.83351204806 125270.984862966 133316.89815209975 145477.85694392797 155744.21719538065 229445.55943563313 328811.00959035155 219644.71436931624 253564.27796293367 0.5864857543382787 0.5169806826307396 0.4940403509096745 0.525771607984892 0.5737316711670013 0.6142198674300152 0.9048812446253717 1.2967560424202085 0.8662289346665154 1.0 17.951991987911995 -7.315684792648422 2.8454154024236034 1.0669103482231985 0.5399064105460699 0.8301294518031079 0.10457767127878968 0.09665318621568736 1.5483568054108665 0.0458067730817942 0.029769947194591865 4.834095293946631e-08 7.315684792648422 -0.5270039376771286 EASRPPEEPSAPS(ph)PTLPAQFK ddPTM_A459_Selumetinib_30min_R1 3 EASRPPEEPSAPSPTLPAQFK 21 1 H0Y3X6;A0A0C4DFX9;Q9H3P2;Q9H3P2-7 H0Y3X6 NELFA Negative elongation factor A 1 EASRPPEEPS(0.004)APS(0.934)PT(0.062)LPAQFK;EASRPPEEPS(0.043)APS(0.928)PT(0.029)LPAQFK;EASRPPEEPSAPS(0.937)PT(0.063)LPAQFK 136.66 1.7864e-05 192000000.0 8132.8 10621.9 11645.7 11763.5 10868.5 9169.1 10125.5 8739.099999999999 5588.0 7348.3 True False 8322.278416325962 9378.283010012658 10064.277905251125 9709.225553243374 9885.446093989522 9076.867178876691 9361.725382913184 8507.310679402557 9482.427868627867 8291.525883503362 1.003708911152745 1.1310684115057137 1.2138028689357157 1.1709817577197263 1.1922348471054511 1.0947161362585658 1.1290714778493387 1.026024738863629 1.143628808720708 1.0 13.017421908939355 -7.460694891701281 1.646496743478609 1.0626199406209698 1.1448206115691169 0.2064117733537283 0.06538719968468958 0.6344648249968629 3.340244375786522 0.04199094793275848 0.021538289486572524 3.461824987134128e-08 7.460694891701281 0.08220067094814709 EASRPPEEPSAPS(ph)PTLPAQFK ddPTM_A459_Selumetinib_30min_R2 3 EASRPPEEPSAPSPTLPAQFK 21 1 H0Y3X6;A0A0C4DFX9;Q9H3P2;Q9H3P2-7 H0Y3X6 NELFA Negative elongation factor A 1 EASRPPEEPS(0.177)APS(0.737)PT(0.086)LPAQFK;EASRPPEEPS(0.002)APS(0.984)PT(0.014)LPAQFK;EASRPPEEPSAPS(0.99)PT(0.01)LPAQFK 96.133 0.00021805 152340700.0 132099.0 127312.0 143119.0 146877.0 144985.0 111043.0 113689.0 123094.0 106775.0 139514.0 True False 124757.46641419546 137076.42102739925 133910.87935618532 126872.09922304253 126770.68811765467 126338.16530200871 118975.76377047984 123452.18316069136 128132.98354276943 135485.86831909535 0.9208153437845457 1.011739620729727 0.9883752528403876 0.9364231177544973 0.9356746182493754 0.9324822350066648 0.8781415010034034 0.9111812522759766 0.945729507678185 1.0 17.0477828553947 -5.857765975869921 5.018614130773213 0.9274195908093571 0.9772755275250613 0.18617686449126547 0.03593326499915013 0.26968158747731635 11.106971658415665 0.01005962170866486 0.01533026146790798 1.3875032981469502e-06 5.857765975869921 0.04985593671570421 EASRPPEEPSAPSPT(ph)LPAQFK ddPTM_A459_Selumetinib_30min_R1 1 EASRPPEEPSAPSPTLPAQFK 21 1 H0Y3X6;A0A0C4DFX9;Q9H3P2;Q9H3P2-7 H0Y3X6 NELFA Negative elongation factor A 1 EASRPPEEPSAPS(0.388)PT(0.612)LPAQFK 121.5 0.00010133 31410000.0 2084.7 2626.0 3220.5 2966.4 2874.3 2385.3 2614.4 2648.4 1292.0 2080.9 True False 2133.269453879934 2318.5466992057195 2783.1737889402293 2448.373926224436 2614.3200724988806 2361.306047679117 2417.193703134485 2578.1558287843986 2192.4296360535423 2348.0037846824644 0.9085460031183169 0.9874544131193858 1.185336159633412 1.0427470101184464 1.1134224269797894 1.0056653498956993 1.029467549798425 1.0980203037164435 0.9337419515062828 1.0 11.197219018552225 -10.034348664047258 12.698849688015274 1.000000223927744 1.0404504916741237 0.010035036918042972 0.07909553683157944 0.0 0.0 0.07657185119047238 0.018571401788670304 9.239560976828683e-11 10.034348664047258 0.04045026774637983 EASS(ph)SSPEAGEGQIR ddPTM_A459_Selumetinib_30min_R1 1 EASSSSPEAGEGQIR 15 0 J3QSS7;Q86U28-2;Q86U28 J3QSS7 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial 1 EAS(0.019)S(0.327)S(0.327)S(0.327)PEAGEGQIR 196.37 3.1676e-05 4228600.0 792.0 1033.3 1038.2 1147.9 994.34 742.25 890.89 715.96 544.9 843.25 True False 810.4520590362686 912.3207556318627 897.2181424243893 947.4408137516958 904.4021225649855 734.7836389090784 823.6894500403458 696.9704150341628 924.6555020786186 951.4893514505677 0.8517720748011688 0.9588344359724136 0.9429618324751183 0.9957450520148231 0.9505120800208676 0.7722457826657583 0.8656843597719849 0.7325046927447114 0.9717980560360027 1.0 9.894043700508995 -6.724267271858919 24.91817053327013 0.8515554315564128 0.9442788483285255 0.1410514218527612 0.08283449960543121 237.80494781857877 159410.90299208162 0.025956037066880253 0.02595541772333279 1.8868298060909936e-07 6.724267271858919 0.09272341677211271 EASSSS(ph)PEAGEGQIR ddPTM_A459_Selumetinib_30min_R1 1 EASSSSPEAGEGQIR 15 0 J3QSS7;Q86U28-2;Q86U28 J3QSS7 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial 1 EASS(0.001)S(0.225)S(0.774)PEAGEGQIR 222.56 1.2955999999999995e-09 4327100.0 601.45 837.02 975.87 903.24 665.32 808.3 611.35 490.07 368.44 574.52 True False 615.4626147820247 739.0213092799589 843.3522140702067 745.506089914698 605.1419234717862 800.16923587768 565.2353772992916 477.0717516282923 625.2157702070953 648.2652382987019 0.949399379175777 1.1399983611946185 1.3009369687683523 1.1500016441899517 0.9334789029563147 1.2343238363013769 0.8719199239846445 0.7359206131124857 0.9644443867573443 1.0 9.340440403633215 -7.2793560276426055 24.128863316754227 0.8710645583345158 1.1204015011148691 0.4358897563416434 0.12434713915161823 474.12950667863174 638520.460312371 0.05254004954652939 0.0355159057328631 5.255862225877455e-08 7.2793560276426055 0.24933694278035334 EASSSS(ph)PEAGEGQIR ddPTM_A459_Selumetinib_30min_R2 1 EASSSSPEAGEGQIR 15 0 J3QSS7;Q86U28-2;Q86U28 J3QSS7 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial 1 EASS(0.001)S(0.063)S(0.937)PEAGEGQIR 259.68 2.4177e-36 6146900.0 23052.0 18917.0 22462.0 22444.0 26656.0 23452.0 27671.0 47856.0 23902.0 35938.0 True False 21770.862124467483 20367.87307225796 21016.819374776445 19387.088481940456 23307.234972336482 26682.300123940346 28957.756329046308 47995.253037012706 28683.06787767996 34900.376561862286 0.6238002070229178 0.5836003813928801 0.6021946306946949 0.555497974286211 0.6678218766787084 0.764527571117891 0.8297261858397874 1.3752073119308394 0.8218555414964678 1.0 15.090954982202156 -7.25242568928995 1.83965019606881 1.0703412063529179 0.6043931343704915 0.656701940632709 0.1392273580648358 0.1968341390708929 1.300519735368768 0.06897888485350136 0.04340345221653695 5.592092038449506e-08 7.25242568928995 -0.4659480719824264 EAT(ph)GLSPQAAQEK ddPTM_A459_Selumetinib_30min_R1 1 EATGLSPQAAQEK 13 0 P17029;C9JRM9 P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 1 EAT(0.847)GLS(0.153)PQAAQEK 143.56 0.001674 19950000.0 5380.6 7369.2 5370.8 6330.4 4980.4 5813.2 5857.6 5797.6 2453.3 4730.2 True False 5505.957511174928 6506.410638151867 4641.474859692655 5224.914476325231 4529.923699361037 5754.724485963294 5415.756516019187 5643.828814741137 4163.070918057396 5337.367246049783 1.0315867837743262 1.219029970809541 0.8696187925100785 0.9789310413654262 0.8487187578695583 1.0781953387641443 1.0146868795710884 1.0574181154422468 0.779985848104889 1.0 12.38191256633246 -5.2622835853691345 24.999735444447246 0.9593076595458665 1.1253083756351816 0.32214272891980833 0.09943115484469132 83.1008798947647 2460989.078712104 0.02504512400081102 0.05760076982911476 5.466588893084455e-06 5.2622835853691345 0.1660007160893151 EAT(ph)GLSPQAAQEK ddPTM_A459_Selumetinib_30min_R2 1 EATGLSPQAAQEK 13 0 P17029;C9JRM9 P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 1 EAT(0.596)GLS(0.404)PQAAQEK 163.64 0.00084883 26874000.0 228170.0 191210.0 219020.0 191980.0 179150.0 157360.0 192020.0 216090.0 174810.0 162980.0 True False 215489.22483687947 205875.19216294546 204928.49165094594 165831.99281602763 156643.57537867944 179034.9116281448 200949.31048041148 216718.78612437492 209776.88459949897 158274.34392710542 1.3614918216696248 1.3007489846728602 1.2947675950900006 1.047750309376755 0.9896965704740053 1.1311682436074468 1.269626557877001 1.3692603661916714 1.3254004369534047 1.0 17.272067889804994 -14.522878745234578 0.015676603696386245 1.8810531961508834e-05 2.131006278879153 0.11834469064296615 0.1346915708625394 18695.234730375767 22.143507087003705 1904.390657564386 1184.6902681103118 3.000000000316093e-15 14.522878745234578 2.1309874683471914 EAT(ph)QARS(ph)RARGR ddPTM_A459_Selumetinib_30min_R1 1 EATQARSRARGR 12 3 Q86SI9-2 Q86SI9-2 2 EAT(1)QARS(1)RARGR 110.51 0.033106000000000003 16658000.0 217.32 212.61 127.88 322.41 294.27 303.14 242.04 219.18 138.35 200.04 True False 222.3831331688912 187.71752236029258 110.51459839455879 266.10714588525485 267.65333045758825 300.0906868290979 223.78272793247808 213.36663440302237 234.76984531579544 225.71708255460618 0.9852295211865126 0.8316496041671076 0.48961557159867486 1.1789411012827413 1.185791201216845 1.3294992272306152 0.9914301806481123 0.9452835026405414 1.040106679825614 1.0 7.818371797423717 -5.787709661307275 24.999980271806457 1.102715057564928 0.7751131018106391 0.4781481212880113 0.15640867681563309 192.48522870901135 183176.85225747465 0.04693875069465411 0.06964514606068785 1.630385629349592e-06 5.787709661307275 -0.32760195575428896 EATAQKPTGSVGSTVT(ph)TPPPLVR ddPTM_A459_Selumetinib_30min_R1 1 EATAQKPTGSVGSTVTTPPPLVR 23 1 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 EATAQKPT(0.001)GS(0.002)VGS(0.011)T(0.011)VT(0.488)T(0.488)PPPLVR 58.29 0.020073 39253000.0 2269.8 2393.3 3451.3 3391.8 2828.5 2757.6 2771.7 2393.9 1386.4 2211.6 True False 2322.6819237380323 2113.091323385016 2982.6324166338813 2799.4858019714275 2572.6626744122354 2729.8610477004704 2562.628437491528 2330.405995516905 2352.6195413503333 2495.480402808272 0.9307554253378298 0.8467673482857501 1.195213720483397 1.1218223949268624 1.030928822970161 1.0939220538972936 1.0269078589467948 0.9338506497163425 0.9427521605470548 1.0 11.285101858955375 -9.920939736240731 9.116243515632906 0.9999999999999932 1.018181592781208 0.0 0.09893661219795277 0.0 0.0 0.10325900692534808 0.02504398778527034 1.199665760140675e-10 9.920939736240731 0.018181592781214673 EATAQKPTGSVGSTVT(ph)TPPPLVR ddPTM_A459_Selumetinib_30min_R2 2 EATAQKPTGSVGSTVTTPPPLVR 23 1 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 EATAQKPTGSVGS(0.012)T(0.012)VT(0.488)T(0.488)PPPLVR;EATAQKPTGSVGS(0.005)T(0.021)VT(0.487)T(0.487)PPPLVR 88.28200000000002 0.0002974 97569000.0 136817.0 134964.0 153470.0 171964.0 185957.0 121218.0 126473.0 127937.0 125981.0 157460.0 True False 129213.25886184572 145315.30482234087 143595.9072855022 148542.20654555352 162595.41918332723 137914.67919255505 132354.2451014953 128309.2754888896 151180.72020324614 152913.72066978773 0.845007617994448 0.9503091297879319 0.9390648965738854 0.9714118909337485 1.0633147795445173 0.9019117355098394 0.8655485231917811 0.8390958962143715 0.9886668085836199 1.0 17.222358337343252 -9.949946871825592 15.214631508221995 0.9999999904859651 0.930107373139956 0.09277567194375247 0.06622365765677946 0.0 0.0 0.06792219022323111 0.016473550859628067 1.1221557216192331e-10 9.949946871825592 -0.06989261734600916 EATAQKPTGSVGSTVTT(ph)PPPLVR ddPTM_A459_Selumetinib_30min_R1 1 EATAQKPTGSVGSTVTTPPPLVR 23 1 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 EATAQKPTGSVGSTVT(0.137)T(0.863)PPPLVR 134.04 8.6788e-06 51498000.0 1309.5 1570.6 2358.1 1948.6 1695.8 1601.7 1616.1 1574.0 688.61 1307.2 True False 1340.0088021565575 1386.7134218478684 2037.8829721161173 1608.3135897522025 1542.4151894178074 1585.5883522272427 1494.1962758704262 1532.2524069274443 1168.5208759155037 1474.991853206265 0.9084855616278232 0.9401498854610612 1.3816232053663668 1.0903881172334133 1.045710988887824 1.0749810914416704 1.0130200194817454 1.0388209288049348 0.7922219186332659 1.0 10.52649127074919 -8.100013390718617 6.118191356188517 0.8971460740978225 1.0698586029561594 0.21015206788606344 0.12884427765400785 0.3691693850638452 18.64244331416162 0.09221028648002223 0.03415689993598693 7.943037433656648e-09 8.100013390718617 0.17271252885833688 EATDAIGHLDR ddPTM_A459_Selumetinib_30min_R1 2 EATDAIGHLDR 11 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 ; 112.43 0.010786 13034300.0 12150.8 14447.3 13268.4 14197.3 14713.2 12406.4 14060.3 13350.7 7465.1 12057.9 False True 12433.889998658951 12755.803399632445 11466.624158104189 11718.008071327597 13382.393657826446 12281.602880109911 12999.720250987533 12996.596066814634 12667.729470668193 13605.648918892146 0.9138770280478025 0.9375373034887261 0.842784069062828 0.8612605059253394 0.983590987655451 0.9026840949170951 0.9554649196435424 0.9552352955960953 0.9310639680756716 1.0 13.731918146849392 -6.258043354588406 24.999972693032245 0.9498751054407513 0.8890498636819266 0.45730944802706996 0.034885939913911625 307.9366284932351 2266888.2161763576 0.01069049039307855 0.01323726126409582 5.520223294497696e-07 6.258043354588406 -0.060825241758824644 EATDAIGHLDR ddPTM_A459_Selumetinib_30min_R2 4 EATDAIGHLDR 11 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 ;;; 145.09 0.0009948 30701000.0 330051.0 285695.0 331772.0 354409.0 377621.0 299170.0 295379.0 311279.0 275289.0 314863.0 False True 311708.08671883686 307606.88784578594 310426.1507260405 306137.8828103744 330180.8740054274 340377.9519051355 309114.7087823844 312184.7703549872 330354.4922173308 305772.0870776786 1.0194131508140254 1.0060005502321774 1.015220694906594 1.0011963019129435 1.0798267335682212 1.113175356057486 1.010931742451222 1.020972101602196 1.080394536252772 1.0 18.222097188288558 -6.246068245028735 24.680007629568657 1.0530490312533634 1.0104795217916418 0.26311832618995634 0.03302350811133532 968.0072015130942 1554239.6353891632 0.010113942763266178 0.01300039456590659 5.674554284641069e-07 6.246068245028735 -0.042569509461721555 EATGLS(ph)PQAAQEK ddPTM_A459_Selumetinib_30min_R1 2 EATGLSPQAAQEK 13 0 P17029;C9JRM9 P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 1 EAT(0.021)GLS(0.979)PQAAQEK;EAT(0.049)GLS(0.951)PQAAQEK 211.75 5.4178e-06 26376600.0 5732.0 6860.0 6187.8 6682.9 5478.8 5394.3 5256.6 6306.700000000001 2569.5 4205.6 True False 5865.54444746956 6056.828010872522 5347.530747152416 5515.856968569742 4983.243507360701 5340.038239632519 4860.090429887063 6139.425828951275 4360.253831145187 4745.429726013057 1.2360407352186382 1.276349742926497 1.1268801891299363 1.1623514174772052 1.050114277331728 1.1253012999771113 1.0241623436641512 1.293755504437615 0.9188322413128471 1.0 12.212323022175383 -1.5228787452803398 0.22085116305867206 1.0265663544103019 2.3222156978821373 0.37545359661656486 0.09313574806952933 57.10401501164168 0.7315943725397909 0.1390079278871537 26.399972043163288 0.029999999999999843 1.5228787452803398 1.2956493434718355 EATGLS(ph)PQAAQEK ddPTM_A459_Selumetinib_30min_R2 1 EATGLSPQAAQEK 13 0 P17029;C9JRM9 P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 1 EATGLS(1)PQAAQEK 92.952 0.017765 29525000.0 181170.0 168970.0 173230.0 176520.0 140720.0 132190.0 161460.0 176690.0 143980.0 150200.0 True False 171101.29668097218 181929.455675817 162084.57039856285 152477.6714860156 123041.49554723837 150397.97259865582 168968.2099269203 177204.13864739577 172780.0231373253 145863.3357335332 1.1730247071378124 1.2472596678316086 1.111208444421311 1.0453461160696724 0.8435395703003369 1.0310882569791673 1.1584008351186734 1.2148641586746427 1.1845336065326533 1.0 17.15425776685813 -5.4283403502864305 4.4677203831287 1.0704185614452197 1.208522519187745 0.23243071272704152 0.10156580778756381 0.3726779593257152 12.575393120032238 0.031008842051726812 0.06693446308849321 3.7295776164897663e-06 5.4283403502864305 0.13810395774252515 EATGLS(ph)PQAAQEKDGIVIVK ddPTM_A459_Selumetinib_30min_R1 2 EATGLSPQAAQEKDGIVIVK 20 1 P17029;C9JRM9 P17029 ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1 1 EAT(0.043)GLS(0.957)PQAAQEKDGIVIVK;EAT(0.037)GLS(0.963)PQAAQEKDGIVIVK 72.433 0.0047272 24411000.0 2637.0 2512.2 3337.8 3947.8999999999996 3272.9 2842.1000000000004 2725.3 2777.4 1615.37 1604.5900000000001 True False 2698.4369692912114 2218.070456109904 2884.5450932230087 3258.4733762612764 2976.8667728774267 2813.5110544203317 2519.7284268483822 2703.7343297333427 2741.1649080431976 1810.5547565301722 1.4903923560216517 1.2250778100523805 1.5931830190825487 1.79970993117378 1.644173843481225 1.5539497186002094 1.391688606909245 1.4933181777472997 1.5139917189229273 1.0 10.822216093500465 -10.057151209889737 0.6210826394992137 0.9344108066681857 1.5361767423780177 0.5484837533331293 0.14272851086856414 10.737309297997976 3.18425518824821 1.7295945654989273 0.06321329973717223 8.766955257281812e-11 10.057151209889737 0.6017659357098321 EATNPPVIQEEKPK ddPTM_A459_Selumetinib_30min_R2 1 EATNPPVIQEEKPK 14 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 125.47 0.0038802 6302300.0 15785.0 14889.0 17912.0 19789.0 18887.0 12838.0 17075.0 17048.0 12626.0 16991.0 False True 14907.732892361588 16030.938424319336 16759.561421111033 17093.704062070916 16514.246208077686 14606.317968239213 17869.02133347062 17097.60685755167 15151.552799915791 16500.4256820803 0.9034756544827569 0.9715469608598746 1.0157047911383377 1.0359553378453095 1.0008375860273955 0.8852085545951633 1.0829430511527127 1.0361918648026105 0.9182522373571609 1.0 14.010215623505658 -4.818872312125545 3.042734279363651 0.9986724305815993 0.8925068179845267 0.21052172408913794 0.05438860479388122 0.5334857513772578 7.627560171107118 0.014014810803235482 0.13275639030580738 1.517496464345485e-05 4.818872312125545 -0.10616561259707258 EATNTTSEPSAPSQDLLDLS(ph)PSPR ddPTM_A459_Selumetinib_30min_R1 2 EATNTTSEPSAPSQDLLDLSPSPR 24 0 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674 I3NI44 TOM1L1 TOM1-like protein 1 1 EATNTTSEPSAPSQDLLDLS(0.917)PS(0.083)PR;EATNTTSEPSAPSQDLLDLS(0.918)PS(0.082)PR 217.63 2.0767e-34 13108700.0 3818.5 4746.5 4769.200000000001 5234.9 4832.6 4073.5 4783.9 5057.5 2492.2 3727.6 True False 3907.4636204924136 4190.777573412014 4121.568835340396 4320.722986243356 4395.49218326483 4032.5242884420754 4423.046571460016 4923.358670924745 4229.081376913807 4206.073769898768 0.929005013762861 0.9963633076061997 0.9799088320411447 1.027258013676576 1.045034496237716 0.9587383648145408 1.0515855910835512 1.1705355018162795 1.005470091176169 1.0 12.038258438234823 -4.6398095224467415 0.4498182363802598 1.0571429037605884 0.8452488615229977 0.280750105508626 0.052975076295867306 7.4134523372715355 1.0618816167260239 0.03919613739053989 0.8641765737481446 2.291872626556303e-05 4.6398095224467415 -0.21189404223759067 EATNTTSEPSAPSQDLLDLSPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 EATNTTSEPSAPSQDLLDLSPSPR 24 0 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674 I3NI44 TOM1L1 TOM1-like protein 1 1 EATNTTSEPSAPSQDLLDLS(0.171)PS(0.829)PR;EATNTTSEPSAPSQDLLDLS(0.026)PS(0.974)PR;EATNTTSEPSAPSQDLLDLS(0.257)PS(0.743)PR 230.74 6.368499999999998e-39 191193700.0 5321.94 6586.4400000000005 6991.959999999999 6743.83 6687.96 5742.37 6464.53 5479.33 3393.0 4740.65 True False 5445.93084730742 5815.2965428471125 6042.490236087107 5566.146687867495 6083.03519885524 5684.606971454794 5976.905297477039 5334.000369027796 5757.673185084882 5349.158605341402 1.0180911147165062 1.0871422913204047 1.1296150819034192 1.04056489974132 1.1371947716751238 1.0627104916609558 1.1173542866178618 0.99716623913554 1.0763698760652858 1.0 12.385096265640442 -7.762018610404089 24.99999655349227 1.0275760440640884 1.0859710131532707 0.3104305345626668 0.04097736918227638 18.82982052663422 812562.5256083378 0.019676794532786337 0.010358564454852916 1.729742234645166e-08 7.762018610404089 0.05839496908918229 EATNTTSEPSAPSQDLLDLSPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 EATNTTSEPSAPSQDLLDLSPSPR 24 0 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674 I3NI44 TOM1L1 TOM1-like protein 1 1 EATNTTSEPSAPSQDLLDLS(0.172)PS(0.828)PR;EATNTTSEPSAPSQDLLDLS(0.124)PS(0.876)PR;EATNTTSEPSAPS(0.007)QDLLDLS(0.1)PS(0.893)PR 178.39 2.4456e-20 59247000.0 90876.8 85691.6 95855.8 105130.1 104915.5 75885.8 74134.2 81411.0 77336.0 87673.3 True False 85826.23126465408 92263.87017807788 89688.54218790395 90811.19902046195 91735.07693352958 86338.38012729469 77581.58719413048 81647.89253168345 92805.3609483833 85141.94402641007 1.0080370168436812 1.0836476807419229 1.0534002155281252 1.0665859237638895 1.0774369552223801 1.0140522525597195 0.911202910401782 0.958962042332005 1.0900075398747782 1.0 16.37758241076893 -6.9610112837157905 6.160549855174532 0.9833160293084277 1.0586868083677166 0.3252184860987677 0.04594013850763093 0.20261322187579092 20.449192876615868 0.016614878922061944 0.014471828439201114 1.0939279437779517e-07 6.9610112837157905 0.0753707790592889 EATQPEPIY(ph)AESTK ddPTM_A459_Selumetinib_30min_R1 4 EATQPEPIYAESTK 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 EATQPEPIY(0.993)AES(0.006)T(0.001)K;EATQPEPIY(0.985)AES(0.012)T(0.003)K;EATQPEPIY(0.958)AES(0.034)T(0.008)K;EATQPEPIY(0.999)AES(0.001)TK 191.48 0.0011283 78602800.0 18704.6 18720.8 18352.9 17886.6 16081.400000000001 14886.9 17303.1 16085.9 9602.49 13678.5 True False 19140.380787184076 16528.960032936193 15860.676985263524 14763.041083065671 14626.840209401766 14737.151302223725 15997.91323619427 15659.249677632895 16294.724191879088 15434.268714872936 1.240122298035398 1.070926024309035 1.0276273711614006 0.956510564626852 0.9476859888610655 0.9548331426951607 1.0365190299413531 1.0145767167150044 1.055749675796236 1.0 13.913849508345074 -4.670585399791918 1.6306362814525146 0.9947924922339898 1.3800746105923913 0.8194193572600421 0.03439181394692 0.5947563331275996 1.2474005802848336 0.010699688023526987 0.3962138737941593 2.135082201587063e-05 4.670585399791918 0.38528211835840154 EATQPEPIY(ph)AESTK ddPTM_A459_Selumetinib_30min_R2 3 EATQPEPIYAESTK 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 EATQPEPIY(0.988)AES(0.006)T(0.006)K;EATQPEPIY(0.669)AES(0.255)T(0.077)K;EATQPEPIY(0.995)AES(0.004)T(0.001)K 168.83 0.0026419 49252000.0 253586.0 201273.0 219133.0 228746.0 253445.0 229640.0 235410.0 220604.0 174619.0 253646.0 True False 239492.70530518887 216709.99190530105 205034.22135397076 197590.40019114036 221604.97327295243 261270.8255356331 246357.03145606548 221245.92111704193 209547.67926251332 246322.58092854728 0.9722726369721678 0.8797812652351341 0.8323809395836375 0.8021611313355674 0.8996535049185569 1.0606856446158381 1.0001398593965212 0.8981958547325406 0.850704301946635 1.0 17.910189363338922 -6.533737049075369 24.986935672921973 0.9604362234401255 0.8671102873710648 0.2875664545098703 0.06763931518178688 298.7917948824374 687569.4805108755 0.02406206452382482 0.024083559928060275 2.92592339134889e-07 6.533737049075369 -0.0933259360690607 EATQPEPIY(ph)AESTKR ddPTM_A459_Selumetinib_30min_R1 4 EATQPEPIYAESTKR 15 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 EATQPEPIY(0.998)AES(0.001)T(0.001)KR;EATQPEPIY(1)AESTKR;EATQPEPIY(0.999)AESTKR;EATQPEPIY(0.983)AES(0.016)TKR 163.62 0.00017298 148019000.0 13617.6 13836.0 16505.0 15689.3 13811.400000000001 12833.0 13965.4 13202.9 7437.2 10644.900000000001 True False 13934.863584762992 12216.074687818102 14263.711655475385 12949.458279636272 12562.161308600715 12703.911671431724 12911.978634391953 12852.716202936686 12620.385208403573 12011.276605106616 1.160148420763082 1.017050484261133 1.1875266988199358 1.078108406406259 1.04586395947787 1.0576653996986993 1.0749880349023353 1.070054135417407 1.0507113959092405 1.0 13.552101873971743 -5.991493662130159 24.999722642680535 1.0556603899133918 1.1147385367681484 0.3247074325154341 0.04550431752360941 257.35269481851964 756338.9437800656 0.01205411100889976 0.017847830304420744 1.0197796420746463e-06 5.991493662130159 0.05907814685475654 EATSDPS(ph)RTPEEEPLNLEGLVAHR ddPTM_A459_Selumetinib_30min_R1 1 EATSDPSRTPEEEPLNLEGLVAHR 24 1 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7 E9PGF5 TNS1 Tensin-1 1 EAT(0.024)S(0.024)DPS(0.476)RT(0.476)PEEEPLNLEGLVAHR 111.45 1.3538e-07 9612900.0 1029.7 1170.5 1256.1 1357.9 1658.1 1366.2 1086.6 957.23 626.79 857.14 True False 1053.690006552582 1033.4573158493126 1085.528519263413 1120.7682559399143 1508.125147761332 1352.4572684103507 1004.6368871733216 931.8411508787524 1063.616851069659 967.162268250626 1.0894655851891997 1.0685459408157012 1.122385100099991 1.158821319577661 1.5593300082820472 1.3983767903359534 1.0387469819211193 0.9634796367358692 1.0997294724839684 1.0 9.917614151825024 -7.406317704530491 8.75512710157067 1.0193142059961822 1.2316284385375 0.3306828413417666 0.14464173279843665 0.44468777768123874 30.68987849635966 0.06964762092696149 0.04683883114085201 3.923578042868221e-08 7.406317704530491 0.21231423254131787 EATSDPS(ph)RTPEEEPLNLEGLVAHR ddPTM_A459_Selumetinib_30min_R2 1 EATSDPSRTPEEEPLNLEGLVAHR 24 1 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7 E9PGF5 TNS1 Tensin-1 1 EAT(0.099)S(0.08)DPS(0.454)RT(0.367)PEEEPLNLEGLVAHR 117.38 6.4476e-08 14787000.0 17230.0 17878.0 24145.0 20439.0 22628.0 13041.0 15019.0 14662.0 15356.0 19154.0 True False 16272.425577154894 19249.185113169522 22591.536987088308 17655.172940758384 19785.268343113366 14837.2793755887 15717.41325958391 14704.66399257523 18427.62908248905 18600.974251931373 0.8748157680754436 1.0348482209834167 1.214535146444955 0.949153130456337 1.0636683904370776 0.7976614114203248 0.8449779590416853 0.7905319255548358 0.9906808553630289 1.0 14.183090566023646 -6.752435323453435 24.9887766726343 0.8691916427779414 1.0338666022622474 0.3105378898700225 0.10476854929256155 211.35097424463322 586557.3171517593 0.034692612507801035 0.03421144215578361 1.7683355444059782e-07 6.752435323453435 0.164674959484306 EATSDPSRT(ph)PEEEPLNLEGLVAHR ddPTM_A459_Selumetinib_30min_R1 1 EATSDPSRTPEEEPLNLEGLVAHR 24 1 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7 E9PGF5 TNS1 Tensin-1 1 EAT(0.015)S(0.063)DPS(0.234)RT(0.688)PEEEPLNLEGLVAHR 97.589 5.0433e-06 9468200.0 671.84 581.07 730.23 995.28 946.47 677.0 922.09 678.54 452.41 670.08 True False 687.4925648269269 513.0380542678855 631.0687768662704 821.4730317194766 860.8619556128504 670.189994666818 852.5360089210825 660.5429149914538 767.7067272809472 756.0912951319261 0.9092718951445806 0.6785398239221474 0.8346462668323125 1.0864733359694907 1.13856879606403 0.8863876610957151 1.1275569688609208 0.8736285144986352 1.0153624730555777 1.0 9.562416634646953 -5.647055195886693 5.574123831751574 1.0164860972122778 0.785868039216657 0.49175544961749473 0.0984652328433529 0.1600897926068992 7.152169636407967 0.02619191090908683 0.04595103176646736 2.2539527318242627e-06 5.647055195886693 -0.23061805799562074 EATSDPSRT(ph)PEEEPLNLEGLVAHR ddPTM_A459_Selumetinib_30min_R2 1 EATSDPSRTPEEEPLNLEGLVAHR 24 1 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7 E9PGF5 TNS1 Tensin-1 1 EAT(0.047)S(0.047)DPS(0.17)RT(0.736)PEEEPLNLEGLVAHR 50.202 0.02293 13671000.0 9850.2 11141.0 18172.0 14951.0 19960.0 9664.8 12283.0 9938.3 9006.6 11605.0 True False 9302.765317474828 11995.478876038811 17002.83330417762 12914.648008086426 17452.446355335993 10996.038471680826 12854.18383830276 9967.21880762586 10808.171665430182 11269.9334965889 0.8254498857771008 1.0643788518955781 1.5086897637261047 1.145938262368215 1.5485846798136271 0.975696837519851 1.1405731757151336 0.8844079524198315 0.9590271023960807 1.0 13.460191381800978 -7.270971315610428 1.947649753176653 0.9584944059621296 1.2151140880354816 0.1889315408310226 0.20931484252640992 0.5604251079558016 4.149152856137665 0.11105001707055547 0.06973577681950825 5.358320471124614e-08 7.270971315610428 0.25661968207335195 EATTDFTVDSRPLTQVGGDHIK ddPTM_A459_Selumetinib_30min_R2 1 EATTDFTVDSRPLTQVGGDHIK 22 1 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 72.359 0.0023882 5195300.0 22736.0 24035.0 20694.0 21939.0 21061.0 14757.0 13534.0 14390.0 14168.0 22015.0 False True 21472.424139419258 25878.407215294188 19362.570569923602 18950.870353114038 18415.128892271096 16789.64279929165 14163.357817112237 14431.872517607255 17001.995886995628 21379.36974816066 1.0043525320135596 1.2104382645573821 0.9056661069996896 0.886409214880829 0.8613504097264332 0.7853198198574642 0.6624777991096187 0.6750373227839832 0.7952524366841247 1.0 14.383931703393388 -5.737315927263871 1.1096214665280222 0.7630059796329256 1.1187089359546696 0.5312282454957948 0.10728875256775054 0.3974788774831989 0.9360299056255674 0.038793003098163206 0.1128015740903525 1.830981991025868e-06 5.737315927263871 0.355702956321744 EAVAPVQEES(ph)DLEK ddPTM_A459_Selumetinib_30min_R1 1 EAVAPVQEESDLEK 14 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4;E7EU01 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 EAVAPVQEES(1)DLEK 103.66 0.006733499999999999 2198000.0 1048.5 1026.8 1160.8 1378.1 1011.2 896.51 1089.0 1177.6 708.23 945.3 True False 1072.92800997415 906.5817786536305 1003.1697358179848 1137.440705140876 919.7371385418601 887.4919233659515 1006.85585324107 1146.3662226161102 1201.8145829273997 1066.638463001746 1.005896606198415 0.8499428907732408 0.9404964949368628 1.0663788571245383 0.8622763667771041 0.8320456782219926 0.943952321396291 1.074746751012516 1.1267309633155733 1.0 10.058855542342203 -7.735948070039587 5.18020017707816 1.0768800957242655 0.9241491918850765 0.42859334103095537 0.07313711298876868 0.16564221182492686 11.670850125903979 0.03850255296479916 0.020477952238950922 1.83675795715786e-08 7.735948070039587 -0.15273090383918897 EAVAPVQEES(ph)DLEK ddPTM_A459_Selumetinib_30min_R2 2 EAVAPVQEESDLEK 14 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4;E7EU01 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 EAVAPVQEES(1)DLEK;EAVAPVQEES(1)DLEK 189.81 9.9015e-05 6087900.0 36075.0 37676.0 34604.0 37664.0 33747.0 29574.0 36774.0 32335.0 25687.0 31375.0 True False 34070.09591966705 40565.62805256599 32377.6163139865 32534.098225976013 29507.400157992153 33647.550053957544 38484.06386629861 32429.089496652585 30825.1177547471 30469.12222796006 1.118184359390654 1.3313684506257568 1.0626369894002101 1.0677727432568118 0.968436174079036 1.1043163568092813 1.2630512811748682 1.064326345013443 1.0116838130131744 1.0 14.895060318181992 -5.28750672010857 24.681811871925184 1.0748062012410466 1.22477641968441 0.327329622037394 0.08957296966972172 680.2815433838235 644122.3410276282 0.024146078442196014 0.050290707183494 5.158141834969512e-06 5.28750672010857 0.14997021844336333 EAVIT(ph)PVASATQSVSR ddPTM_A459_Selumetinib_30min_R1 3 EAVITPVASATQSVSR 16 0 P28749;P28749-2;H0YE05 P28749 RBL1 Retinoblastoma-like protein 1 1 EAVIT(0.971)PVAS(0.014)AT(0.014)QS(0.001)VSR;EAVIT(1)PVASATQSVSR;EAVIT(0.999)PVAS(0.001)ATQSVSR 142.4 0.00092252 165413000.0 17101.399999999998 19515.6 19700.4 21021.5 18462.300000000003 17389.3 18346.199999999997 17600.2 9318.2 15038.5 True False 17499.829346468214 17230.704479443702 17025.1938865512 17350.48964742683 16792.3882247838 17214.379430221117 16962.331363389632 17133.385522493267 15812.30482559917 16968.837962394755 1.0312921477151358 1.0154322009338106 1.0033211422185382 1.0224913270948706 0.989601542662969 1.014470140405048 0.9996165560058066 1.0096970435137145 0.9318437043621597 1.0 14.050600151071636 -8.219895408796818 21.873207726644836 0.9659219307050543 1.010090018922018 0.4749536122769199 0.018839136868120124 79.12156346314337 41658.137125777364 0.011732544546274207 0.004434160683172897 6.027047180624046e-09 8.219895408796818 0.04416808821696383 EAVIT(ph)PVASATQSVSR ddPTM_A459_Selumetinib_30min_R2 4 EAVITPVASATQSVSR 16 0 P28749;P28749-2;H0YE05 P28749 RBL1 Retinoblastoma-like protein 1 1 EAVIT(1)PVASATQSVSR;EAVIT(1)PVASATQSVSR;EAVIT(0.977)PVAS(0.013)AT(0.01)QSVSR;EAVIT(0.998)PVAS(0.002)AT(0.001)QSVSR 214.63 2.5431e-08 185889700.0 203268.0 181116.0 203393.0 225552.0 246145.0 201336.0 181389.0 182306.0 166912.0 184874.0 True False 191971.1783062753 195007.0148202712 190306.91581755484 194831.4285010977 215222.06453578037 229068.2064537634 189823.94791548493 182836.48027761688 200299.0639109411 179536.20725966216 1.0692616338309326 1.0861709612603863 1.0599918463372409 1.08519296177018 1.1987669107017838 1.2758886352236651 1.0573017599783852 1.0183822141969479 1.1156471831960322 1.0 17.453915297684894 -7.4878658516228205 24.987386628383234 1.047777091531985 1.1287138300464337 0.2566980402178364 0.06803098732197746 960.822637771699 685705.1298861742 0.03140859226703289 0.021165301927797937 3.251877284781391e-08 7.4878658516228205 0.0809367385144486 EAVITPVAS(ph)ATQSVSR ddPTM_A459_Selumetinib_30min_R2 1 EAVITPVASATQSVSR 16 0 P28749;P28749-2;H0YE05 P28749 RBL1 Retinoblastoma-like protein 1 1 EAVIT(0.363)PVAS(0.495)AT(0.138)QS(0.003)VSR 72.48899999999998 0.037188 3527300.0 25497.0 18468.0 25474.0 24103.0 26746.0 22236.0 20460.0 22554.0 18378.0 22844.0 True False 24079.978812577963 19884.436216020513 23835.03057399409 20820.12982000583 23385.928367726272 25298.807161689307 21411.43054072087 22619.62840598429 22054.113524224 22184.434364159984 1.0854447950893138 0.8963237867423283 1.0744033488859523 0.938501720541577 1.0541593255813346 1.1403854949108254 0.9651555766196167 1.0196170898333736 0.9941255730122864 1.0 14.43726014882548 -4.465776502091837 23.09102355981883 1.012411957731136 2.606243191412907 0.10529800076479046 0.06608760562220324 871.7022568515931 489874.1854611177 0.015587704778942843 27469.11829585679 3.421554782759558e-05 4.465776502091837 1.593831233681771 EAVLSQS(ph)QHSLGGHR ddPTM_A459_Selumetinib_30min_R1 1 EAVLSQSQHSLGGHR 15 0 F5H0R1;Q9H6E5;H3BRB1;C9JBX0 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 EAVLSQS(0.5)QHS(0.5)LGGHR 101.97 0.006596600000000001 7687600.0 133.52 0.0 133.4 229.64 162.78 91.889 116.45 0.0 55.145 0.0 True False 136.63075621530623 0.0 115.28501271374836 189.53768487667853 148.05657774114323 90.96468008853655 107.66608274556712 0.0 93.5770373685547 0.0 0.0 EAVTHIGR ddPTM_A459_Selumetinib_30min_R2 1 EAVTHIGR 8 0 D6RBW1;P06730;P06730-3;P06730-2 D6RBW1 EIF4E Eukaryotic translation initiation factor 4E 0 124.08 0.007862899999999999 2989400.0 27406.0 23979.0 27166.0 26568.0 26744.0 24499.0 21967.0 25030.0 21781.0 23625.0 False True 25882.88423491047 25818.112195362577 25418.1691361044 22949.392567643645 23384.17962560648 27873.51487022066 22988.509026784723 25102.833156060424 26137.808611988425 22942.88486487828 1.1281442759856604 1.1253210896283488 1.107888972367872 1.0002836479720703 1.019234493104385 1.2149088937324681 1.0019885974311924 1.0941445813768897 1.139255536778683 1.0 14.485759188452292 -8.592096369215234 0.00803312520268239 7.096731254544479e-05 2.134231078145956 0.10185324886760228 0.06667509752141791 7321.75684492596 36.1753921150238 4861.008005646463 4745.385777227191 2.558018203986076e-09 8.592096369215234 2.1341601108334105 EAVVDLHADDS(ph)RISEDETER ddPTM_A459_Selumetinib_30min_R1 1 EAVVDLHADDSRISEDETER 20 1 Q9UKV3-5;G3V3T3 Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 EAVVDLHADDS(0.811)RIS(0.18)EDET(0.009)ER 74.812 0.0034789 44461000.0 2783.2 3590.9 2359.5 2625.9 2659.5 2723.4 3172.7 2715.8 1556.8 2669.9 True False 2848.0431448355303 3170.4757586358814 2039.0928598057676 2167.335859247823 2418.948694572862 2696.0050686493555 2933.3806846445736 2643.768161838344 2641.775895826745 3012.6076720283077 0.9453747234594339 1.0524024711459643 0.676853105944891 0.71942187473373 0.8029418224724394 0.894907456314817 0.9737015250544082 0.8775680240030611 0.8769067145235372 1.0 11.556797089531765 -6.938936355450019 5.951595227076315 0.9235810832355853 0.8360523126674996 0.1448904488201418 0.10558268978062813 0.4748268107579809 33.10224898306914 0.04173028181762712 0.0365778322647556 1.150969047637781e-07 6.938936355450019 -0.08752877056808572 EAVVDLHADDS(ph)RISEDETER ddPTM_A459_Selumetinib_30min_R2 2 EAVVDLHADDSRISEDETER 20 1 Q9UKV3-5;G3V3T3 Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 EAVVDLHADDS(0.768)RIS(0.225)EDET(0.006)ER;EAVVDLHADDS(0.664)RIS(0.168)EDET(0.168)ER 116.87 0.00014578 52003000.0 95273.0 63227.0 109672.0 106277.0 121661.0 93578.0 86093.0 101782.0 89284.0 89204.0 True False 89978.10806803711 68076.30759315193 102615.82292184504 91801.88926194921 106376.85751686024 106467.52008349344 90096.49509004304 102078.16876908272 107143.29480339603 86628.44874017352 1.0386669665286319 0.7858423945387109 1.1845510847091674 1.0597198795200926 1.2279667830128014 1.2290133510623473 1.040033573269577 1.1783446460555684 1.236814191660676 1.0 16.40255326265853 -5.275629596851804 24.975084560103184 1.15015746359779 0.9122546765711824 0.4713072159678331 0.09827156797686723 534.7519225773966 941174.681429244 0.024421695931129847 0.05122213351722958 5.301153784714842e-06 5.275629596851804 -0.2379027870266076 EAVVDLHADDSRIS(ph)EDETER ddPTM_A459_Selumetinib_30min_R1 3 EAVVDLHADDSRISEDETER 20 1 Q9UKV3-5;G3V3T3 Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 EAVVDLHADDS(0.207)RIS(0.773)EDET(0.02)ER;EAVVDLHADDS(0.203)RIS(0.593)EDET(0.203)ER;EAVVDLHADDS(0.324)RIS(0.675)EDET(0.001)ER 135.69 5.9955e-05 85054000.0 6824.6 8085.4 5288.9 5713.1 6738.6 5446.700000000001 7703.099999999999 6972.1 3360.15 6480.799999999999 True False 6983.599901640041 7138.757609199517 4570.696429848154 4715.414333169102 6129.094819796458 5391.911143207915 7122.048965198613 6787.177259427467 5701.929134353957 7312.673808337788 0.9549995097111343 0.9762171534384626 0.625037646918795 0.644827659042123 0.8381468913338056 0.7373378444776449 0.9739322649778488 0.9281389321220429 0.7797324595352132 1.0 12.83618329476816 -7.259949777006526 24.99286183486346 0.9144624921042531 0.7915422482147505 0.2033258919710076 0.12015602940602123 250.13239806752534 4196828.041417811 0.051525994556716075 0.03774308349686848 5.496044279315962e-08 7.259949777006526 -0.12292024388950262 EAVVDLHADDSRIS(ph)EDETER ddPTM_A459_Selumetinib_30min_R2 1 EAVVDLHADDSRISEDETER 20 1 Q9UKV3-5;G3V3T3 Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 EAVVDLHADDS(0.088)RIS(0.894)EDET(0.019)ER 91.091 0.00087727 11575000.0 20903.0 15784.0 22848.0 26156.0 24568.0 16223.0 26234.0 26657.0 20754.0 20378.0 True False 19741.294941338878 16994.58204644076 21377.984555021467 22593.507678383292 21481.54819929331 18457.570992268647 27453.932981684804 26734.567456696073 24905.379915210833 19789.634191597463 0.9975573449316658 0.8587618084247629 1.080261734403277 1.1416839472442768 1.0854949612163232 0.9326888417222791 1.387288552981012 1.3509379303255327 1.2585063308439264 1.0 14.272457324181165 -7.258623390551976 24.999715111424447 1.2784280332936886 1.0207067415320354 0.455070047349158 0.12325436007982991 212.8199229242882 1889376.5581059135 0.048936901055482276 0.03619048082299351 5.512855503969168e-08 7.258623390551976 -0.25772129176165315 EAVVDLHADDSRISEDET(ph)ERNGDDGTHDK ddPTM_A459_Selumetinib_30min_R1 2 EAVVDLHADDSRISEDETERNGDDGTHDK 29 2 Q9UKV3-5;G3V3T3 Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 EAVVDLHADDS(0.023)RIS(0.026)EDET(0.95)ERNGDDGT(0.001)HDK;EAVVDLHADDS(0.131)RIS(0.131)EDET(0.686)ERNGDDGT(0.053)HDK 83.992 3.825e-06 22680400.0 2354.48 2871.2 3609.4 3281.5 3341.1000000000004 2861.7 2830.6 2416.0 1462.35 1893.3 True False 2409.3348029794342 2535.038569215332 3119.263305015018 2708.447626383994 3038.898094919114 2832.9138962157085 2617.085563070865 2351.919831725987 2481.501144181811 2136.3234973037193 1.127794927135467 1.186636093463764 1.4601081292004134 1.2678078155309154 1.4224896644888032 1.326069717339703 1.2250417908963327 1.1009193292562547 1.1615755513215789 1.0 11.060914411377588 -7.629920684056244 2.59325464553425 1.092071051026853 1.3045730418706014 0.4726806843519872 0.0993573927370382 0.2719578308004467 3.6733054550892517 0.060144389702694284 0.030022231953057477 2.3446569849339454e-08 7.629920684056244 0.21250199084374843 EAVVDLHADDSRISEDET(ph)ERNGDDGTHDK ddPTM_A459_Selumetinib_30min_R2 1 EAVVDLHADDSRISEDETERNGDDGTHDK 29 2 Q9UKV3-5;G3V3T3 Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 EAVVDLHADDS(0.093)RIS(0.091)EDET(0.781)ERNGDDGT(0.035)HDK 42.31399999999999 0.039582 12446000.0 20850.0 26713.0 22906.0 26707.0 23577.0 16737.0 11138.0 11518.0 7761.9 20006.0 True False 19691.24046916307 28761.801204167004 21432.252898167095 23069.460527855288 20615.04647894571 19042.369826641207 11655.9390695283 11551.515473092453 9314.496885606395 19428.37479816952 1.0135299876456119 1.480401809361679 1.1031418284243917 1.1874107210464573 1.0610793076159926 0.980131895974918 0.5999441121872163 0.5945693138563911 0.4794274859513199 1.0 14.245877602722553 -6.975877558266425 1.7420533277560206 0.6283337382914717 1.201975872454039 0.6447787543958148 0.1738896874124566 0.20228520351366439 1.2432083045914804 0.07707472232696969 0.05967663297588791 1.0571155024321759e-07 6.975877558266425 0.5736421341625674 EAWPHIK ddPTM_A459_Selumetinib_30min_R1 2 EAWPHIK 7 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 ; 117.17 0.016565 19356900.0 16594.699999999997 18595.4 20992.1 22523.6 20158.8 17885.8 18827.6 17032.2 10527.400000000001 14879.2 False True 16981.32422233479 16418.241923233076 18141.488121351413 18590.276080335996 18335.4400993252 17705.885091007047 17407.418973812273 16580.450727617284 17864.228909125446 16789.090255681345 1.011449933482155 0.9779113503590359 1.080552182701646 1.1072831104737875 1.0921044452137945 1.0546065820937178 1.036829197336746 0.9875729104503767 1.0640379339839618 1.0 14.035236437151617 -10.077907540597717 11.96844479168993 1.000006564905095 1.046291256379193 0.10096802735009891 0.04099251016818562 0.0 0.0 0.04407238934707057 0.010689124497136385 8.357809334097836e-11 10.077907540597717 0.04628469147409797 EAYPEEAYIADLDAK ddPTM_A459_Selumetinib_30min_R2 2 EAYPEEAYIADLDAK 15 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 ; 147.96 0.0043475 7337800.0 67011.0 52751.0 73106.0 71958.0 63587.0 44994.0 56828.0 55049.0 50643.0 69571.0 False True 63286.79688628717 56796.83207880109 68402.43955179438 62157.19626552632 55598.6325850075 51191.5150851344 59470.614602545706 55209.183476147446 60773.0150836476 67562.30446283388 0.9367175585477746 0.840658596985026 1.012434967925386 0.9199981670210654 0.8229238630484013 0.7576934429951975 0.8802336609945058 0.8171595672335021 0.8995106896787235 1.0 16.043930916990142 -4.73549861812769 23.583204423854117 0.8769463358348715 0.936718140773515 0.0363361077014277 0.07609450088278437 4582.819646053221 4165874.6944101867 0.01956378011797316 1.3253520228804936 1.8386598042469675e-05 4.73549861812769 0.059771804938643536 EAYPGDVFYLHSR ddPTM_A459_Selumetinib_30min_R1 4 EAYPGDVFYLHSR 13 0 P25705-2;P25705-3;P25705 P25705-2 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 ;;; 147.73 0.00079438 32634000.0 9393.3 12852.0 10970.6 14379.199999999999 11297.5 12203.7 10775.599999999999 9974.5 5900.0 7721.6 False True 9612.145613819925 11347.281865267303 9480.852777192269 11868.14265101348 10275.643119735625 12080.941858073045 9962.787816514672 9709.943858257806 10011.86908104946 8712.742574753283 1.1032284646711383 1.3023777264059269 1.0881594051297603 1.362159222447766 1.1793810079401545 1.386583128609781 1.1434732210938512 1.1144532017270992 1.1491064949010001 1.0 13.088911202819258 -8.295634603245137 0.9959050005924567 1.0137090087722798 1.2329546813615628 0.3240722246993518 0.0986801162882796 0.5723802919979325 1.191321985654134 0.08867950062654485 0.03058178524994156 5.062504202666121e-09 8.295634603245137 0.21924567258928307 EAYPGDVFYLHSR ddPTM_A459_Selumetinib_30min_R2 2 EAYPGDVFYLHSR 13 0 P25705-2;P25705-3;P25705 P25705-2 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 ; 140.08 0.0012654 8740600.0 60624.0 42716.0 49366.0 57337.0 40251.0 34659.0 54078.0 41496.0 41510.0 47241.0 False True 57254.76077710037 45992.17984641177 46189.845305636845 49527.60168815811 35194.30953149442 39432.962646923464 56592.73415352412 41616.74648996738 49813.15988630639 45877.02958314142 1.248004966697756 1.002509976437373 1.0068185696706566 1.0795729832159442 0.7671444697114259 0.8595360903970563 1.23357450706269 0.9071369020207973 1.085797409704385 1.0 15.485484363222223 -4.759583822520216 5.109392482155458 0.9890040770864387 1.2640562734959357 0.2790540545790553 0.12268360283376362 0.23434403038702295 16.71489987008381 0.03099734799242617 0.23160966098215946 1.7394669337581806e-05 4.759583822520216 0.2750521964094971 EAYSGCSGPVDSECPPPPS(ph)SPVHK ddPTM_A459_Selumetinib_30min_R1 1 EAYSGCSGPVDSECPPPPSSPVHK 24 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 EAYSGCSGPVDSECPPPPS(0.867)S(0.133)PVHK 199.87 5.6798e-31 237160000.0 3995.3 4451.0 4335.2 4041.3 4484.4 4006.2 3820.7 3446.0 1995.7 3292.2 True False 4088.3827164994973 3929.8748507862374 3746.5036515490388 3335.5628195964173 4078.7868117851262 3965.9012653385603 3532.5015229367805 3354.600885814467 3386.5571398390516 3714.785938743622 1.1005702034831728 1.0579007554107844 1.008538234323172 0.8979152162734142 1.0979870385652997 1.0675988686120277 0.9509300350510932 0.9030401592800867 0.9116426075911171 1.0 11.859063363794535 -7.385859895679277 5.194178194131628 0.9300989804397091 1.0339706694751967 0.3862321810618762 0.05953409614369513 0.25258726804265524 9.640152535863695 0.027036171043766096 0.01789509801557581 4.1128238027325004e-08 7.385859895679277 0.1038716890354876 EAYSGCSGPVDSECPPPPS(ph)SPVHKAELEK ddPTM_A459_Selumetinib_30min_R1 1 EAYSGCSGPVDSECPPPPSSPVHKAELEK 29 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 EAYSGCSGPVDSECPPPPS(0.5)S(0.5)PVHKAELEK 81.94 8.3804e-06 11929000.0 1408.7 892.86 4355.7 4178.8 2806.6 2027.8 1382.5 1553.0 995.27 860.38 True False 1441.5199691469577 788.3235361206475 3764.2198641474783 3449.051025791085 2552.7435255454748 2007.4021730950867 1278.2169119428645 1511.8093951450576 1688.9004983552697 970.8181538108985 1.48485065250206 0.812019772215963 3.8773686394009217 3.552726133367002 2.629476504456377 2.0677427232022074 1.3166388647815117 1.557252910043477 1.7396671989760129 1.0 9.923057276187217 -7.048425105239052 3.4649208733210934 1.4546938583768028 2.512035077824957 0.2574297377302217 0.8506067776177105 0.40356629377383785 9.771574987205792 0.378091224110563 0.29826393164683057 8.944887746171569e-08 7.048425105239052 1.0573412194481544 EAYSGCSGPVDSECPPPPS(ph)SPVHKAELEK ddPTM_A459_Selumetinib_30min_R2 1 EAYSGCSGPVDSECPPPPSSPVHKAELEK 29 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 EAYSGCSGPVDSECPPPPS(0.5)S(0.5)PVHKAELEK 68.587 0.00018849 4702900.0 8630.3 21175.0 14911.0 20466.0 16775.0 8525.1 3825.4 4275.1 2362.3 21570.0 True False 8150.6624758282 22799.054411643636 13951.642493869274 17678.495494180785 14667.57452959725 9699.355141847342 4003.2886798862964 4287.539833219098 2834.8260081768613 20947.21805440952 0.38910477060281684 1.0884048828070652 0.6660379654057388 0.8439543355237737 0.7002158707423028 0.46303786577547784 0.19111314301917906 0.2046830191046082 0.13533186129124733 1.0 14.35447103561695 -6.834886572122412 2.929245214597 0.3170071202807596 0.7655096488168096 0.25552297972204496 0.28157295809113897 0.28360261550536714 4.930711882463614 0.09990526271794047 0.08898785617955775 1.462559111876375e-07 6.834886572122412 0.44850252853605 EAYSGCSGPVDSECPPPPSS(ph)PVHK ddPTM_A459_Selumetinib_30min_R1 1 EAYSGCSGPVDSECPPPPSSPVHK 24 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 EAYSGCSGPVDSECPPPPS(0.245)S(0.755)PVHK 188.53 1.9875e-26 169500000.0 3900.5 4638.0 3900.3 4210.3 4113.5 3562.9 3928.6 3674.8 1925.4 2903.3 True False 3991.374060948186 4094.980803852299 3370.66068281434 3475.050142119316 3741.434651297409 3527.060460854365 3632.262539065995 3577.3323665673242 3267.2631743479033 3275.9668355368317 1.2183804847017388 1.250006794766973 1.0289056184117293 1.0607708553160187 1.1420856312436696 1.076647181709453 1.108760473294223 1.0919928516251625 0.9973431778690451 1.0 11.677705036497928 -1.522878752844925 0.485766326153587 1.0583777488346222 6.687727577425086 0.5287326222520123 0.055788435254106296 83.4170351047279 0.9209623807210099 0.03238610452848057 475.6497072181098 0.029999999477456817 1.522878752844925 5.629349828590464 EAYSGCSGPVDSECPPPPSS(ph)PVHK ddPTM_A459_Selumetinib_30min_R2 4 EAYSGCSGPVDSECPPPPSSPVHK 24 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 EAYSGCSGPVDSECPPPPS(0.21)S(0.79)PVHK;EAYSGCSGPVDSECPPPPS(0.226)S(0.774)PVHK;EAYSGCSGPVDSECPPPPS(0.259)S(0.741)PVHK;EAYSGCSGPVDSECPPPPS(0.222)S(0.778)PVHK 220.5 1.3669e-34 629440000.0 439718.0 442274.0 527711.0 519352.0 572797.0 474442.0 492606.0 470431.0 458233.0 566284.0 True False 415280.2338906211 476194.99366494775 493758.6487882936 448615.3616678281 500837.11998984835 539792.078944333 515513.1550802707 471799.8763259555 549892.4040997796 549933.9095374697 0.755145712400057 0.8659131313896588 0.8978508875795217 0.8157623195942634 0.9107223819151015 0.9815580919502369 0.9374092888977348 0.8579210485906751 0.9999245264986022 1.0 19.068898721961844 -1.5235741485736654 0.2055285933980913 0.989450698733721 7.744015092658305e-15 0.6127626535980415 0.04784617768874568 39.68548054019944 0.48777936931188554 0.08705372432260344 12.749004399636423 0.02995200168061091 1.5235741485736654 -0.9894506987337133 ECDS(ph)DDNMGAK ddPTM_A459_Selumetinib_30min_R1 1 ECDSDDNMGAK 11 0 Q9Y4E5;Q9Y4E5-2 Q9Y4E5 ZNF451 Zinc finger protein 451 1 ECDS(1)DDNMGAK 107.17 0.010702 2549700.0 1512.6 1582.1 1290.7 1371.5 1979.8 1563.8 1593.8 1530.2 700.32 1375.1 True False 1547.8406369927518 1396.8669965016643 1115.4300293076096 1131.9932712435311 1800.727439562079 1548.069591816795 1473.5783828242577 1489.6141252098942 1188.3918906509418 1551.6074796082737 0.9975722966890616 0.9002708577135269 0.7188867313202283 0.7295616231041369 1.1605560447650713 0.9977198564469593 0.9497108013402232 0.9600457234106459 0.7659101327295541 1.0 10.599547920250748 -6.23560957914107 24.99372184548688 0.9704652548072537 0.8327165964112411 0.24578563903956918 0.11639198506216623 1195.404124647807 1156710.4256556195 0.03634677729801957 0.04690752733568356 5.812867462657889e-07 6.23560957914107 -0.13774865839601258 ECDS(ph)DDNMGAK ddPTM_A459_Selumetinib_30min_R2 4 ECDSDDNMGAK 11 0 Q9Y4E5;Q9Y4E5-2 Q9Y4E5 ZNF451 Zinc finger protein 451 1 ECDS(1)DDNMGAK;ECDS(1)DDNMGAK;ECDS(1)DDNMGAK;ECDS(1)DDNMGAK 167.98 0.00050533 23306100.0 125028.0 97269.0 105486.0 118264.0 113954.0 94427.0 117194.0 114813.0 97709.0 112827.0 True False 118079.44428673963 104729.21953086986 98699.14560447287 102156.23918322097 99638.07975831452 107433.46212703892 122643.75321550538 115147.08682168456 117253.53021756465 109569.3913502484 1.077668159251593 0.9558255114888199 0.9007912190455835 0.9323428552840033 0.9093605297104593 0.9805061505144096 1.1193249474523739 1.050905598750718 1.0701303418100883 1.0 16.74148530636098 -7.079357691242073 5.994868130178422 1.0636100863213238 0.9503137855747301 0.4674189167924222 0.05300154744678675 0.19898533586376252 11.858917454661436 0.02075252085203888 0.016117388175777046 8.329948353717551e-08 7.079357691242073 -0.11329630074659369 ECDY(ph)SIDGINR ddPTM_A459_Selumetinib_30min_R2 1 ECDYSIDGINR 11 0 H0YMT1;A0A1B0GVU7;Q9Y4G6;H0YN01 H0YMT1;H0YN01 TLN2 Talin-2 1 ECDY(0.777)S(0.223)IDGINR 117.53 0.036829 0.0 6587.6 7626.8 11215.0 14760.0 16112.0 7581.7 8013.3 11154.0 10427.0 12921.0 True False 6221.487564252216 8211.75103597278 10493.439109968747 12749.6625375798 14087.866516892445 8626.01035517988 8385.934328052716 11186.456293355897 12512.691354722145 12547.93715721026 0.4958175584006047 0.6544303603922791 0.8362680637063151 1.0160763779609483 1.1227237067247597 0.6874444976179394 0.6683117888611686 0.8914976344879101 0.9971911078254116 1.0 13.615162588532147 -5.115238323639753 2.303027224885451 0.8977323321998981 0.5005559641680146 0.5022552026391051 0.1356097980433897 0.33073097290487774 3.0904976567393043 0.040815959556819735 0.19659126568260654 7.669405072375111e-06 5.115238323639753 -0.3971763680318835 ECEEEAINIQSTAPEEEHES(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ECEEEAINIQSTAPEEEHESPR 22 0 P46939;P46939-2 P46939 UTRN Utrophin 1 ECEEEAINIQSTAPEEEHES(1)PR;ECEEEAINIQSTAPEEEHES(1)PR 206.04 1.9403e-23 44380000.0 261683.0 164258.0 218949.0 307990.0 297714.0 263783.0 306950.0 323240.0 312140.0 230821.0 True False 247139.7064600477 176856.06042728524 204862.05971364686 266041.2306876161 260312.50572307108 300116.7138663383 321223.78320988605 324180.5748847372 374576.72192029987 224156.59798501898 1.1025314832649482 0.7889844065134546 0.9139238441124913 1.1868543379008474 1.161297539590909 1.3388707562665452 1.4330329158160866 1.4462236570274996 1.6710492811161146 1.0 17.77414743976417 -6.330336330320578 1.1272563448675554 1.4236759916245574 0.91894923889847 0.5147195879487548 0.178675296905271 0.35109355792886215 0.929929968834221 0.0753767273454755 0.10464563308454033 4.6737305376777914e-07 6.330336330320578 -0.5047267527260874 ECINAAPDS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 ECINAAPDSPSK 12 0 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 ECINAAPDS(0.702)PS(0.298)K;ECINAAPDS(0.795)PS(0.205)K 245.39 3.673e-14 114231000.0 17376.8 21463.6 17196.7 17184.7 15657.7 16794.199999999997 19666.6 18244.1 10652.7 17552.5 True False 17781.645630633117 18950.63173384306 14861.48259471152 14183.714741770855 14241.463799591469 16625.265595913548 18183.13252832949 17760.207202811303 18076.853857575534 19805.534350828457 0.8978119608214115 0.9568351652703763 0.7503701910516679 0.7161490566487825 0.7190648607264543 0.839425248590585 0.9180834107396298 0.8967295144989815 0.9127173010012419 1.0 14.273616005048016 -7.192348750571733 3.73037250340083 0.9243985207506925 0.8059725817029352 0.3752355861265697 0.07536040115287007 0.3144688686423228 8.603042515387536 0.035012697251676494 0.025907703821986323 6.421718283341587e-08 7.192348750571733 -0.11842593904775733 ECINAAPDS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 ECINAAPDSPSK 12 0 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 ECINAAPDS(0.5)PS(0.5)K;ECINAAPDS(0.765)PS(0.235)K;ECINAAPDS(0.5)PS(0.5)K 163.9 0.00046905 207414000.0 577203.0 481755.0 502261.0 532317.0 488997.0 407013.0 472058.0 474643.0 354365.0 483573.0 True False 545124.367986682 518704.05941352394 469946.07408042904 459814.50630195515 427564.82517135394 463075.34625385207 494009.63236518105 476024.13254862174 425247.90178537613 469610.99101645587 1.1607998501201604 1.1045398624312601 1.000713533265582 0.9791391494196152 0.9104659672592106 0.9860828539203105 1.0519550049199555 1.0136562849993882 0.9055322595089662 1.0 18.841106648854485 -5.160122706545192 2.2184870740607856 0.9792020170111564 1.1613354932375362 0.6928250639981621 0.0414626641286777 0.21225033861353002 1.858027221740695 0.01215543112938381 0.0547183407366982 6.916355270435274e-06 5.160122706545192 0.18213347622637976 ECINAAPDSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 ECINAAPDSPSK 12 0 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 ECINAAPDS(0.276)PS(0.724)K;ECINAAPDS(0.284)PS(0.716)K 177.39 0.00010365 118237000.0 14141.599999999999 18291.4 13881.400000000001 14388.8 12381.3 13241.9 15929.4 14140.8 8099.799999999999 13214.2 True False 14471.071765236478 16149.834384558837 11996.382125072161 11876.066191227808 11261.413601096054 13108.698508683214 14727.832533166491 13765.740048208127 13744.769014014308 14910.371287207936 0.9705373183866759 1.0831275810290704 0.8045662910731287 0.7964970128823451 0.7552738549681567 0.8791664711883846 0.9877575983504817 0.9232325461954242 0.9218260732250421 1.0 13.864028562559426 -9.206375014655729 12.026458315607883 1.0000000000000029 0.8998698705102667 0.08774521593247941 0.09403976668783982 6103707.416802046 444995.1675707908 0.10117011807129322 0.02529252950953372 6.217631588474888e-10 9.206375014655729 -0.10013012948973621 ECINAAPDSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 ECINAAPDSPSK 12 0 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 ECINAAPDS(0.18)PS(0.82)K 163.64 0.00050271 158000000.0 335670.0 274910.0 309030.0 301550.0 300160.0 243600.0 310780.0 287300.0 246000.0 275360.0 True False 317014.8051934758 295994.71302502713 289147.34624642436 260478.36979723474 262451.21733555326 277153.68881936994 325231.8857988868 288135.9954349245 295206.8738142945 267409.64132879983 1.1855025257061795 1.106896189509786 1.0812899071611872 0.9740799490357844 0.9814575721032069 1.0364386543512434 1.2162309637855961 1.0775078789348513 1.1039500010073158 1.0 18.0286919564967 -2.800358087399028 0.005930651450744766 1.0898999393349018e-07 2.213844193005359 0.06965660514251426 0.07476764781376782 136119.09004718714 78.08877316197727 13582.179748239867 15631.09571227592 0.0015835869442884568 2.800358087399028 2.2138440840153653 ECLS(ph)LDPEER ddPTM_A459_Selumetinib_30min_R2 1 ECLSLDPEER 10 0 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 ECLS(1)LDPEER 152.69 0.00062396 7375700.0 62341.0 33457.0 52970.0 66010.0 75842.0 42352.0 69941.0 96570.0 52403.0 41743.0 True False 58876.33679079591 36023.044318789194 49561.96786937533 57019.32412639851 66314.04992391741 48185.603566822545 73193.39508546224 96851.00271197583 62885.064262156426 40537.77112866092 1.452382189537039 0.8886291307052219 1.2226120600482187 1.4065727478066707 1.6358583138043377 1.1886594212071633 1.805560420506524 2.389154608539897 1.5512708891312372 1.0 15.306979147435994 -6.427682542121949 0.9839790361332024 1.740683383834264 1.1589609347135468 0.16256252242592806 0.37649004989029816 0.7621497345974702 1.5855904192549783 0.18870615923928005 0.2455949362388824 3.7352309361588514e-07 6.427682542121949 -0.5817224491207171 ECPDQLGPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 ECPDQLGPSPK 11 0 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 ECPDQLGPS(1)PK;ECPDQLGPS(1)PK;ECPDQLGPS(1)PK;ECPDQLGPS(1)PK 146.84 0.00067699 34189600.0 10888.8 13144.5 13509.800000000001 14614.3 10641.099999999999 10109.0 10884.4 11744.8 7260.7 11381.8 True False 11142.48785408348 11605.535829287739 11675.243364019481 12062.18684938706 9678.614383838789 10007.312638237614 10063.380944919285 11433.289751512993 12320.877599453535 12842.764898120462 0.8676081780266944 0.9036633405152662 0.9090911074552297 0.9392204050353955 0.7536238855587284 0.7792179267956687 0.7835836772494419 0.8902514250016563 0.9593633222435377 1.0 13.648668210934408 -8.257125372169032 2.745740331968149 0.9931375241096209 0.8493662446564624 0.4451753882182895 0.0583063067203485 0.28727096216794795 4.000211071120776 0.06076472902143731 0.017518405933147744 5.531903911126234e-09 8.257125372169032 -0.14377127945315848 ECPDQLGPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 ECPDQLGPSPK 11 0 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 ECPDQLGPS(1)PK;ECPDQLGPS(1)PK;ECPDQLGPS(1)PK;ECPDQLGPS(1)PK 142.95 0.00087949 39938300.0 227571.0 210582.0 193252.0 200490.0 203122.0 159831.0 201803.0 184940.0 134309.0 164100.0 True False 214923.51485889233 226732.96227214826 180818.37671686854 173182.91613545932 177603.99842628016 181846.26944864026 211187.23936505814 185478.1447815348 161174.5529070083 159362.00661699582 1.3486496525826936 1.4227541876845782 1.134639181291436 1.0867265028337658 1.1144688887679886 1.1410892301681554 1.325204443946398 1.1638793255616156 1.0113737667370661 1.0 17.28194819285757 -5.266692596068089 24.711056702067157 1.1344111485621866 1.3857019298256483 0.5914183280048021 0.08714179418153381 242.48510396436342 1140653.0631841489 0.023491067005958325 0.05140808049964446 5.411372171720863e-06 5.266692596068089 0.2512907812634617 ECPSDECGAGVFMASHFDR ddPTM_A459_Selumetinib_30min_R1 2 ECPSDECGAGVFMASHFDR 19 0 P62979;A0A2R8Y422 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 ; 207.56 3.1656e-16 147662000.0 10425.7 10601.2 12626.400000000001 12379.7 12081.5 10342.4 11206.3 10633.3 5904.700000000001 9338.2 False True 10668.598525119214 9360.006575635833 10911.804231850614 10217.817790749945 10988.73045816207 10238.364846147857 10360.999768756115 10351.270342173819 10019.844637775044 10536.848931770766 1.012503699559666 0.888311736862193 1.0355851452846856 0.9697223388997372 1.0428858313635672 0.9716723578789368 0.9833110293074023 0.9823876577524624 0.9509336902006018 1.0 13.363155869846175 -4.4205325898861565 23.26130396087339 0.9812002694919427 8.532358147622439 0.05143779153412931 0.04109621353539089 3336.143632671118 803667.3834445636 0.009497706102043849 80499.03645138454 3.7972344308057266e-05 4.4205325898861565 7.551157878130496 ECPSDECGAGVFMASHFDR ddPTM_A459_Selumetinib_30min_R2 4 ECPSDECGAGVFMASHFDR 19 0 P62979;A0A2R8Y422 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 ;;; 156.13 5.0499e-05 18681300.0 62252.0 56328.0 73312.0 71167.0 81535.0 58021.3 56843.0 64980.0 47837.9 67789.0 False True 58792.28305450071 60648.17647693332 68595.18573607031 61473.93183007735 71291.8443678516 66013.20741007925 59486.312132267645 65169.081041981924 57406.816702605014 65831.75543302573 0.893068742702955 0.9212602045624326 1.0419771626150236 0.9338036244927141 1.0829400476853566 1.0027562986260958 0.9036112092254072 0.9899338186155772 0.8720231797708651 1.0 16.00649604792342 -5.021315903068092 20.31785291182367 0.9785806739847288 0.9001162498298196 0.19420311630380127 0.05925513280368125 94.44249039828236 90028.87538160892 0.01498371322814334 0.041015204137855636 9.521033581027979e-06 5.021315903068092 -0.07846442415490917 ECS(ph)PTSSLER ddPTM_A459_Selumetinib_30min_R1 2 ECSPTSSLER 10 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 ECS(0.989)PT(0.008)S(0.001)S(0.002)LER;ECS(0.495)PT(0.495)S(0.007)S(0.002)LER 158.08 0.00048138 52660000.0 4787.1 5583.4 5118.0 5567.2 5606.4 5229.8 5213.4 4871.5 2984.2 4460.5 True False 4898.630115924896 4929.692932347761 4423.003711161653 4594.993029286904 5099.302109890316 5177.192960278471 4820.149040667581 4742.291995137894 5063.969442655561 5033.048623949311 0.9732928254686838 0.9794645950548259 0.8787921678553205 0.9129641639903976 1.0131636888278297 1.0286395676058566 0.9576996768382753 0.9422305146372166 1.0061435565233994 1.0 12.297216820345438 -6.259886102660099 24.999842127731718 0.9886100387820547 0.9351284296652886 0.3612926341491729 0.035827584756347806 182.96512402075336 2944806.0731479386 0.011885027352015355 0.014527083730303052 5.496850144225233e-07 6.259886102660099 -0.05348160911676603 ECS(ph)PTSSLER ddPTM_A459_Selumetinib_30min_R2 1 ECSPTSSLER 10 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 ECS(0.857)PT(0.044)S(0.097)S(0.002)LER 108.98 0.010346 85072000.0 57392.0 55419.0 64657.0 70249.0 66910.0 58980.0 56105.0 52111.0 56833.0 56076.0 True False 54202.38239837924 59669.45909982898 60497.03901321884 60680.965013715686 58504.1676170106 67103.95963286718 58713.99366994842 52262.63438255954 68201.18804669834 54456.94017705459 0.9953255218187487 1.095718174870403 1.1109151343525034 1.1142925918427489 1.0743197731418137 1.2322388921355778 1.0781728367229773 0.9597056722731621 1.252387442720017 1.0 15.732828302155088 -4.7615625000511725 4.6116566870216555 1.1044217311770146 0.9866773862574105 0.12498362716874734 0.08474250572263411 0.4159480179147523 20.270102677129138 0.02024046494351265 0.16226885667339405 1.7315598211249433e-05 4.7615625000511725 -0.11774434491960406 ECS(ph)VEKGTGDSLR ddPTM_A459_Selumetinib_30min_R1 3 ECSVEKGTGDSLR 13 1 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 ECS(1)VEKGTGDSLR;ECS(0.995)VEKGT(0.005)GDSLR;ECS(0.988)VEKGT(0.012)GDSLR 191.63 0.0008207 56749200.0 6870.299999999999 6151.57 17783.5 17423.399999999998 10274.6 9489.5 7651.700000000001 7326.0 4888.02 5825.98 True False 7030.364622723323 5431.341324612693 15368.598377773198 14380.730267724795 9345.264244127966 9394.044245776615 7074.526108580987 7131.690681798255 8294.612933144308 6573.801282850849 1.069451953326231 0.8262101470547178 2.3378556358047264 2.187582138395326 1.4215921415980528 1.4290125060949084 1.076169753873818 1.084865570914469 1.2617681271842762 1.0 12.682512131013581 -7.0185979766583895 2.3153267905541712 1.112099825975363 1.6061376436634058 0.20503423934537846 0.4288641469771125 0.5564686072522058 5.963694978527431 0.20483194755124692 0.15980485732581176 9.580805493416433e-08 7.0185979766583895 0.4940378176880429 ECS(ph)VEKGTGDSLR ddPTM_A459_Selumetinib_30min_R2 1 ECSVEKGTGDSLR 13 1 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 ECS(0.991)VEKGT(0.003)GDS(0.007)LR 103.66 0.039449 8294000.0 19750.0 29031.0 25748.0 27541.0 22313.0 12357.0 8453.5 9399.0 7190.2 26171.0 True False 18652.37406551417 31257.58435062226 24091.401712302726 23789.868289125036 19509.84145924909 14059.064584322476 8846.604500292464 9426.349533911785 8628.440910973743 25415.37522957588 0.7339011876483491 1.229869087836555 0.9479065917652696 0.9360423788447853 0.767639323953222 0.5531716316335137 0.3480808140891687 0.3708916137874817 0.33949689245322745 1.0 14.633413910270969 -6.585917420512734 1.8746464228777167 0.4600459506973668 0.9872780944765588 0.47958675257162287 0.21304873410291114 0.2505931144047839 1.7942236801800495 0.07801143778849692 0.08103122033610345 2.5946726826166745e-07 6.585917420512734 0.527232143779192 ECSEAMEVETSVISIDS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 2 ECSEAMEVETSVISIDSPQK 20 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 ECSEAMEVETSVIS(0.022)IDS(0.978)PQK;ECSEAMEVETSVISIDS(1)PQK 220.69 9.3954e-20 13017800.0 5181.6 6554.7 4359.8 4266.0 5025.1 4434.0 6417.4 5838.0 3307.9 5630.7 True False 5302.321198361523 5787.272676802644 3767.763106667168 3521.0231827378125 4570.580592253461 4389.397985749884 5933.330351321616 5683.157275503444 5613.264700542968 6353.455192662571 0.8345571090963271 0.910885888277957 0.5930258406509977 0.5541902911039878 0.7193850359615187 0.6908678589280174 0.9338745881412455 0.8944986787766701 0.8834979598228019 1.0 12.633325669245716 -7.262701038113136 24.85951489623683 0.9191760392330733 0.7130101386592199 0.5084751782744159 0.10134586134653169 102.59898873624705 2021557.6536362714 0.045404057435043166 0.0325312668218533 5.4613368205688576e-08 7.262701038113136 -0.20616590057385342 ECSEAMEVETSVISIDS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 ECSEAMEVETSVISIDSPQK 20 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 ECSEAMEVETSVIS(0.083)IDS(0.916)PQK;ECSEAMEVETSVIS(0.01)IDS(0.99)PQK 135.64 0.00012093 0.0 26621.0 22009.0 24195.0 26641.0 25866.0 20589.5 25646.0 25181.0 19063.2 22843.0 True False 25141.511392306486 23697.019529910973 22638.320041524177 23012.449841711612 22616.48183502607 23425.51673212816 26838.589816584918 25254.272541061033 22876.372670311623 22183.463236758307 1.1333447408088495 1.0682290351600594 1.0205043189114027 1.0373695755304637 1.0195198826101348 1.0559900626026577 1.2098467011279375 1.1384278582441696 1.0312354038753135 1.0 14.43719699322143 -7.04500376279701 24.995957618149973 1.110199613223 1.0519256558979262 0.06470449360355846 0.06184647011640234 829.3323081410678 460624.3925180433 0.023709653812966858 0.018366241132938648 9.015633262829355e-08 7.04500376279701 -0.0582739573250739 ECSPT(ph)SSLER ddPTM_A459_Selumetinib_30min_R1 1 ECSPTSSLER 10 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 ECS(0.214)PT(0.736)S(0.014)S(0.037)LER 126.66 0.007996099999999999 40334000.0 3924.5 3757.3 3510.2 3674.7 3823.7 3220.5 3189.4 3354.3 2058.0 2887.0 True False 4015.933214252316 3317.3935692786195 3033.5341201484216 3032.9826276621257 3477.8470101290654 3188.104693980041 2948.8209901993305 3265.3330676980468 3492.275689627085 3257.5745717613886 1.2327985517399465 1.0183630477827823 0.9312247665624959 0.9310554711329831 1.0676185405783587 0.9786743553367728 0.9052197962746519 1.0023816786893887 1.0720478112458964 1.0 11.669582489726851 -4.771559159718866 3.990740325184175 0.9833568627485871 1.2577645717928745 0.6648578675722614 0.05219224424312769 0.14490850955760165 4.338055714138958 0.013574113453052955 0.11711295063194144 1.692157722525679e-05 4.771559159718866 0.27440770904428735 ECSPT(ph)SSLER ddPTM_A459_Selumetinib_30min_R2 1 ECSPTSSLER 10 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 ECS(0.215)PT(0.74)S(0.038)S(0.007)LER 124.39 0.0090221 91049000.0 89832.0 82436.0 79983.0 93313.0 87301.0 65450.0 82057.0 80553.0 74607.0 77736.0 True False 84839.49706598828 88758.57612648186 74836.98085890584 80603.60842609633 76333.46789915771 74465.14340405505 85872.81309286076 80787.39589373289 89530.48469375253 75491.559697616 1.1238275829220612 1.1757417184385557 0.9913291122698736 1.0677168248868723 1.0111523487514895 0.98640356223037 1.137515418105378 1.070151368144062 1.1859668160569197 1.0 16.204027733085475 -10.979096830957342 17.691814835837967 1.000029869456325 1.07910088252416 0.11402814771394465 0.06877200459845928 9.325700188824004e-11 0.0 0.0687112665942853 0.016664929990483093 1.049308447163666e-11 10.979096830957342 0.07907101306783493 ECT(ph)MDLSEFMNPSPYT(ph)VPQEAS(ph)LPR ddPTM_A459_Selumetinib_30min_R2 1 ECTMDLSEFMNPSPYTVPQEASLPR 25 0 P51798-2;P51798 P51798-2 CLCN7 H(+)/Cl(-) exchange transporter 7 3 ECT(0.815)MDLS(0.168)EFMNPS(0.082)PY(0.453)T(0.485)VPQEAS(0.997)LPR 44.415 0.038957 1658400.0 4267.1 4667.5 4045.2 4582.0 4881.2 3464.8 2392.2 3071.5 2316.6 4397.0 True False 4029.9516645547137 5025.482241622036 3784.9362360807463 3957.9236956091236 4267.980017518334 3942.044749677151 2503.4420400543727 3080.4375564858033 2779.9847312121733 4270.0471852220035 0.9437721621676162 1.1769149200539237 0.8863921338339881 0.9269039717656768 0.9995158911332821 0.9231852901579121 0.5862797134229365 0.7214059758277938 0.6510430940513459 1.0 12.06003629678178 -7.092747805716978 5.550945308257015 0.7176868004210603 0.9861333930413514 0.4684003933920674 0.12391340330124707 0.18324027816383495 8.655828956224203 0.04605565714068079 0.03569916203666966 8.077039267901498e-08 7.092747805716978 0.26844659262029114 ECT(ph)PLVQGR ddPTM_A459_Selumetinib_30min_R1 1 ECTPLVQGR 9 0 F8WEN6 F8WEN6 XXYLT1 1 ECT(1)PLVQGR 91.069 0.037878 0.0 963.39 985.92 1053.4 1110.3 1153.8 1455.4 1102.2 1011.4 767.6 807.78 True False 985.8351125693819 870.4880280582264 910.3540659120129 916.4069479122811 1049.4389937199344 1440.7599973974702 1019.0601666136886 984.5743865097946 1302.5611367141632 911.4664314435099 1.0815923423620688 0.9550412368776049 0.9987795869456921 1.00542040419519 1.151374266255658 1.5807054957753146 1.1180446492141023 1.0802091580602722 1.429082950044872 1.0 9.832045713749753 -6.408067569275412 4.53730636469304 1.2502389522937771 1.007327090756346 0.3089650734067029 0.1614604585415638 0.2738304031288149 9.008810494325585 0.05095207513752852 0.057670075584455055 3.907800919301828e-07 6.408067569275412 -0.24291186153743105 EDAEGVAAEEEQEGDS(ph)GEQETGATDARPR ddPTM_A459_Selumetinib_30min_R2 2 EDAEGVAAEEEQEGDSGEQETGATDARPR 29 1 Q96KC8 Q96KC8 DNAJC1 DnaJ homolog subfamily C member 1 1 EDAEGVAAEEEQEGDS(0.998)GEQET(0.002)GATDARPR;EDAEGVAAEEEQEGDS(1)GEQETGATDARPR 121.5 7.4669e-14 11947000.0 23701.2 10219.2 19899.1 21558.2 16366.0 15500.5 29112.3 22222.7 19737.5 16919.5 True False 22383.982187420985 11002.979780092963 18618.81357050193 18621.935970030678 14309.956766103649 17635.553175470635 30466.079634928075 22287.364377833965 23685.551511827784 16430.99007285962 1.362302702890339 0.6696480085072576 1.1331522621546777 1.1333422932796984 0.8709126292846193 1.0733104394360684 1.8541840448952214 1.3564224845250068 1.4415169996938348 1.0 14.004131794114338 -7.034628496228957 24.24350892983211 1.4457349994845778 1.0194219242270055 0.3322917352152215 0.25717334635429284 428.3835699729685 299911.14491672453 0.09247167048266722 0.07167298760561548 9.233609499623827e-08 7.034628496228957 -0.42631307525757234 EDAEHHPDEDVDESES ddPTM_A459_Selumetinib_30min_R1 1 EDAEHHPDEDVDESES 16 0 Q5JY65;Q9BZJ0-2;Q9BZJ0-3;Q9BZJ0 Q5JY65 CRNKL1 Crooked neck-like protein 1 0 127.71 0.0014254 2942700.0 1977.7 2365.2 1419.0 1418.0 1861.9 1416.8 1944.3 1901.0 902.32 1883.1 False True 2023.776562065691 2088.281284448352 1226.3075940090635 1170.3729191566376 1693.491473745144 1402.5482783514747 1797.6398856350884 1850.5793046817475 1531.1711371546699 2124.8142279473054 0.9524487060785438 0.9828065234981759 0.5771363810914182 0.5508118798165645 0.7970068401608716 0.6600804248691511 0.8460221425435923 0.8709369884394624 0.7206141209972368 1.0 11.053120996907744 -10.699512920884716 8.224034165353025 1.0000000390422676 0.7693645059690495 0.1915244458472024 0.1396679251172129 1.0749487086084217e-07 1.0808497141504192e-08 0.14549436693979592 0.03528756144094567 1.9975013390243378e-11 10.699512920884716 -0.23063553307321816 EDAEHHPDEDVDESES ddPTM_A459_Selumetinib_30min_R2 1 EDAEHHPDEDVDESES 16 0 Q5JY65;Q9BZJ0-2;Q9BZJ0-3;Q9BZJ0 Q5JY65 CRNKL1 Crooked neck-like protein 1 0 78.486 0.03674 4119100.0 25756.0 25097.0 29560.0 33872.0 33661.0 24441.0 28779.0 31223.0 28384.0 29628.0 False True 24324.584629437137 27021.859200425974 27658.14178249451 29258.57516754085 29432.204246841917 27807.525896692234 30117.28052450664 31313.85376075409 34061.59311522331 28772.56265721118 0.845409041913781 0.9391537181570293 0.9612679312582063 1.0168915266992342 1.0229260631904615 0.9664598259106725 1.0467361174364647 1.0883234188702338 1.183822015474404 1.0 14.812406101433071 -3.1931831362692047 0.3368249418494495 1.0848230373297985 0.2345182850795427 0.6343654884273138 0.05212462980716879 13.065638766800262 0.5095925228502515 0.049866947739917004 5.604284312261447 0.0006409392439446816 3.1931831362692047 -0.8503047522502558 EDALDDSVSSSSVHASPLAS(ph)SPVRK ddPTM_A459_Selumetinib_30min_R2 2 EDALDDSVSSSSVHASPLASSPVRK 25 1 P49792;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 EDALDDSVSSSSVHAS(0.006)PLAS(0.497)S(0.497)PVRK;EDALDDSVSSSSVHAS(0.202)PLAS(0.399)S(0.399)PVRK 96.455 4.7421e-06 10868900.0 18081.9 22076.1 27234.6 36332.0 63519.0 27430.0 18853.3 24754.4 40073.0 41705.0 True False 17076.980385580802 23769.265884150464 25482.355486790428 31383.51892380417 55539.17535293521 31208.233515251744 19730.015807105217 24826.431205688466 48088.71973317162 40500.868287396814 0.42164479695599194 0.5868828716333239 0.6291804735139495 0.7748850889098147 1.3713082632901987 0.7705571469183345 0.48715044001278524 0.6129851594666683 1.1873503400453274 1.0 15.30566521743544 -5.6794873666112204 2.751696952537922 0.8718198579959099 0.5208066736419401 0.2964019212449387 0.2468479866248322 0.400388031925868 6.1105057035632955 0.07673219880011635 0.14641842803751326 2.091763754480588e-06 5.6794873666112204 -0.3510131843539698 EDARPVPQGSCQSELHR ddPTM_A459_Selumetinib_30min_R1 1 EDARPVPQGSCQSELHR 17 1 P22692-2;P22692 P22692-2 IGFBP4 Insulin-like growth factor-binding protein 4 0 119.96 0.0011828 3154300.0 3481.5 4335.2 4391.9 5108.4 5716.5 4424.1 4868.7 4273.1 1951.2 3442.4 False True 3562.6121761802606 3827.632768620196 3795.504102979845 4216.313836544263 5199.443584330045 4379.597570761405 4501.45003918714 4159.763507015032 3311.0438899904584 3884.26557181552 0.9171906787297972 0.9854199456375343 0.9771484551726498 1.0854854691548657 1.338591166901033 1.1275226911723146 1.1588934783064138 1.0709266475491641 0.8524246936192018 1.0 11.923426127551817 -5.765909513714773 4.50321192510445 1.109326002538209 0.9597515175614182 0.1984867580818822 0.11723742588307161 0.2999828588085847 14.849758303503506 0.03490650204454035 0.05749246227088823 1.7143144517827047e-06 5.765909513714773 -0.14957448497679082 EDAS(ph)PLPHVCCCK ddPTM_A459_Selumetinib_30min_R2 2 EDASPLPHVCCCK 13 0 C9J7Z4;Q8NCE0-5;Q8NCE0-3;Q8NCE0-2;Q8NCE0 C9J7Z4 TSEN2 tRNA-splicing endonuclease subunit Sen2 1 EDAS(1)PLPHVCCCK;EDAS(1)PLPHVCCCK 110.25 0.0037419 55020000.0 190044.0 134820.0 183839.0 196416.0 192816.0 136977.0 179913.0 178790.0 168531.0 171574.0 True False 179482.11528640887 145160.2604853742 172010.9988887691 169663.8019635013 168592.73028308936 155844.3383965964 188279.3109908461 179310.24929972197 202241.9091495808 166620.21281721175 1.0771929302677525 0.8712043876970684 1.0323537341623206 1.0182666262083608 1.0118384044320092 0.9353267275415327 1.1299908204858384 1.0761614468493785 1.213789766139882 1.0 17.34620390012416 -7.272023648967716 24.775410587893692 1.1113323038514393 0.9896459806405205 0.37229132809204335 0.07228873071464731 634.3473676434046 1484858.499073496 0.02840478737205346 0.019373376872807123 5.3453525114989256e-08 7.272023648967716 -0.12168632321091888 EDAVLEYLK ddPTM_A459_Selumetinib_30min_R2 1 EDAVLEYLK 9 0 P26038 P26038 MSN Moesin 0 133.57 0.042803 1235200.0 19740.0 16898.0 18710.0 19047.0 17328.0 15273.0 17166.0 16976.0 14248.0 20027.0 False True 18642.929825481 18194.022264366195 17506.21896990772 16452.76574209231 15151.101725714516 17376.717115510008 17964.25301378371 17025.39734947192 17097.99812238238 19448.768473604985 0.958566083543149 0.9354845418134481 0.9001196653488056 0.8459541160367702 0.7790262785161398 0.8934610507134643 0.9236704646962097 0.87539719404743 0.8791301179602726 1.0 14.24739118394992 -10.271038947823781 14.868199538579734 0.9999960454921043 0.8860453485058628 0.3331264784570953 0.04753294765978754 0.0 0.0 0.050812591726056046 0.012323863693995008 5.3574860906012944e-11 10.271038947823781 -0.1139506969862415 EDDDVIVNKPHVS(ph)DEEEEEPPFYHHPFK ddPTM_A459_Selumetinib_30min_R1 1 EDDDVIVNKPHVSDEEEEEPPFYHHPFK 28 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;H7C1M2;H7C2G8;J3QSZ5 P18583-10 SON Protein SON 1 EDDDVIVNKPHVS(0.951)DEEEEEPPFY(0.049)HHPFK 47.331 0.017897999999999997 4916300.0 1308.0 1550.9 1509.6 1223.9 1323.8 1152.6 1539.4 1471.2 922.55 1782.5 True False 1338.4738550750492 1369.3199070061514 1304.6046116392392 1010.1688404483845 1204.062523735873 1141.0058904770676 1423.2818186219502 1432.1789968689047 1565.4999696139287 2011.3012380203236 0.6654765729635196 0.6808129389677803 0.6486371046653016 0.5022464170720989 0.5986485271201858 0.5672973639692743 0.7076422923215883 0.7120658854058901 0.7783518152431574 1.0 10.97391345882212 -8.56113067123959 0.8719447192599267 0.9977700074870726 0.6124953714638647 0.8269739284363642 0.053529029423261196 0.286732133391769 0.48084927654191595 0.05657506871977817 0.019880585185361302 2.7470674865507155e-09 8.56113067123959 -0.3852746360232079 EDDDVIVNKPHVS(ph)DEEEEEPPFYHHPFK ddPTM_A459_Selumetinib_30min_R2 1 EDDDVIVNKPHVSDEEEEEPPFYHHPFK 28 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;H7C1M2;H7C2G8;J3QSZ5 P18583-10 SON Protein SON 1 EDDDVIVNKPHVS(0.999)DEEEEEPPFY(0.001)HHPFK 58.361 0.0024806 34397000.0 217620.0 169840.0 193830.0 205280.0 209950.0 193600.0 210780.0 227180.0 174250.0 174930.0 True False 205525.5516018835 182866.18187832646 181359.18882614712 177320.50987224796 183574.20402318588 220266.64267417934 220581.68765264636 227841.05618832665 209104.86895179166 169879.31637727696 1.2098326976160034 1.0764475969058387 1.0675766343642157 1.0438028222249565 1.0806153917849222 1.2966065991518327 1.2984611214396866 1.3411936252576222 1.2309024630603087 1.0 17.374150682600806 -6.755563280867708 24.995007907768382 1.2588216420054419 1.0901473336502683 0.3173777014666751 0.09737178746149394 136.51686922746887 580697.8224497384 0.031189433482660275 0.03039764167234369 1.755645061251773e-07 6.755563280867708 -0.1686743083551736 EDDLGEPQAAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 EDDLGEPQAASPR 13 0 Q6ZVF9 Q6ZVF9 GPRIN3 G protein-regulated inducer of neurite outgrowth 3 1 EDDLGEPQAAS(1)PR 127.3 0.001941 5938700.0 26410.0 17562.0 25669.0 27307.0 20807.0 19192.0 21995.0 23638.0 17056.0 21027.0 True False 24942.237927606562 18908.948929269685 24017.48448629405 23587.73949279755 18193.0386430599 21835.523792370084 23017.811082265664 23706.782666518433 20467.67658445776 20419.89587529294 1.2214674393998959 0.9260061385596278 1.176180556109202 1.1551351503872038 0.8909466901382477 1.0693259126159396 1.1272247039279017 1.1609649143805119 1.0023399095400205 1.0 14.317687889223464 -7.953630469746457 0.008023647649810662 1.857027956593684e-07 2.126848986856186 0.06107913406140031 0.1040013507082346 6776.007642165553 55.73531387916285 7384.752844887621 7381.4542416404665 1.1126780744062497e-08 7.953630469746457 2.12684880115339 EDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R2 2 EDDSSASTSQSTR 13 0 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 ; 199.8 0.0017414000000000002 3212600.0 5543.8 3940.8 3196.24 4006.6000000000004 2922.6499999999996 6308.700000000001 8688.5 13061.1 7025.1 8926.6 False True 5235.697789589751 4243.046688330827 2990.597398202988 3460.8941682294885 2555.48057817749 7177.666160323323 9092.53246593613 13099.105638618496 8430.316297694315 8668.865863907839 0.603965717290445 0.48945810847027044 0.34498139031705544 0.39923263579826024 0.29478834005461296 0.8279821458775811 1.0488722064315465 1.5110518312615289 0.9724820328335329 1.0 13.081627544597902 -7.051104458533323 2.5448105163963572 1.1816399899061474 0.42503803002395396 0.8019876414119821 0.1647110192660195 0.11637798879450699 1.493942485102891 0.06859336963298696 0.052912823189216016 8.889872687789428e-08 7.051104458533323 -0.7566019598821934 EDEEEDDDVVAPKPPIEPEEEK ddPTM_A459_Selumetinib_30min_R2 1 EDEEEDDDVVAPKPPIEPEEEK 22 1 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 0 82.36 0.0026067 3370600.0 21232.0 15970.0 16695.0 15725.0 16391.0 12503.0 21394.0 18852.0 13198.0 18503.0 False True 20052.010438430225 17194.84764835649 15620.861876141615 13583.227872861951 14331.816042600814 14225.17475906644 22388.863391406758 18906.856198883383 15837.968782931128 17968.77031343252 1.1159367106740956 0.95692956993849 0.8693339390322258 0.7559353053062198 0.7975958172211202 0.7916610046727816 1.2459875106016578 1.0522064598237755 0.8814163967075412 1.0 14.133204061440429 -7.234403074897277 24.989615401818497 1.0492532125866803 0.8746350781482795 0.2839907306210555 0.1269821128525441 985.6396130759431 911026.3044677937 0.05182108184931767 0.0401298919507481 5.8290385176940817e-08 7.234403074897277 -0.1746181344384008 EDEEES(ph)LNEVGYDDIGGCR ddPTM_A459_Selumetinib_30min_R2 2 EDEEESLNEVGYDDIGGCR 19 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 EDEEES(1)LNEVGYDDIGGCR;EDEEES(1)LNEVGYDDIGGCR 216.9 4.713899999999999e-19 13528300.0 29981.0 25855.2 28322.6 29040.4 35569.0 27880.0 34609.6 32222.0 28608.0 29757.9 True False 28314.776043452173 27838.21070242872 26500.35475131526 25085.047422515767 31100.504229105478 31720.21693055844 36219.01497762136 32315.76068536074 34330.39937430626 28898.712106690436 0.9797936994187684 0.9633028143141301 0.9170081577849994 0.8680334033539248 1.0761899739436933 1.097634275653924 1.2533089656004488 1.1182422443621358 1.1879560323506013 1.0 14.818717578895033 -6.493914826589403 3.0384972813432896 1.1456799198826764 0.9337610931819094 0.6533033242586423 0.0680511732242987 0.15008312039899907 2.802224111250116 0.02259372271291793 0.024520204753073493 3.2068981965859424e-07 6.493914826589403 -0.211918826700767 EDEEES(ph)LNEVGYDDIGGCRK ddPTM_A459_Selumetinib_30min_R1 1 EDEEESLNEVGYDDIGGCRK 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 EDEEES(1)LNEVGYDDIGGCRK 133.41 6.8317e-05 5323500.0 1074.4 1216.4 1081.3 1095.0 1044.3 1176.5 1432.0 1391.0 815.48 1082.8 True False 1099.431429581523 1073.9833225109826 934.465399155743 903.7788056957106 949.8432493861394 1164.665478176532 1323.9830870901858 1354.1061613952188 1383.8099996973237 1221.7879273651652 0.8998545532795459 0.879025973703203 0.7648343695545881 0.7397182321524047 0.7774207193506278 0.9532468377619182 1.0836439429757738 1.1082988553630606 1.1326106345489644 1.0 10.25477817481847 -7.022520750223719 2.8401021888281974 1.0901537675410553 0.8096345437372828 0.8323746454618405 0.05673298150538151 0.1111651436700706 1.8043199084362929 0.025272340911837755 0.020059178845681758 9.494656334520002e-08 7.022520750223719 -0.2805192238037725 EDEEES(ph)LNEVGYDDIGGCRK ddPTM_A459_Selumetinib_30min_R2 2 EDEEESLNEVGYDDIGGCRK 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 EDEEES(0.849)LNEVGY(0.151)DDIGGCRK;EDEEES(1)LNEVGYDDIGGCRK 88.62700000000002 0.0010026 14228100.0 20965.3 26665.5 18785.1 25135.3 20587.2 19116.5 29204.0 26561.3 14729.2 16886.1 True False 19800.132556745553 28710.658106903586 17576.487117670426 21711.828779189007 18000.851884096843 21749.624352690833 30562.043866628163 26638.58898554006 17675.451568233762 16398.554417643238 1.207431585276965 1.7508042096694652 1.071831496242123 1.3240087038299673 1.0977096776731545 1.3263135151285268 1.86370353680361 1.624447393782439 1.0778664459116414 1.0 14.001281022050266 -7.026644285845052 24.968700574486807 1.4651797305245442 1.296301155370594 0.0010728521922375167 0.29251579664040184 2225.2914017172393 2085343.348567823 0.1107465554700109 0.08606370048888155 9.404933176214779e-08 7.026644285845052 -0.1688785751539501 EDEEESLNEVGYDDIGGCR ddPTM_A459_Selumetinib_30min_R2 2 EDEEESLNEVGYDDIGGCR 19 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ; 236.12 1.2298e-24 38410000.0 46446.0 33536.0 45114.0 49080.0 47798.0 33024.0 46150.0 62666.0 40999.0 41805.0 False True 43864.71725806945 36108.103364764145 42211.41435640928 42395.21933227756 41793.1879204584 37572.75623797569 48296.06644449015 62848.34768508523 49199.94560777342 40597.98102756558 1.0804654849285682 0.8894063805844715 1.0397417134548685 1.0442691547516039 1.029440057427518 0.9254833685562888 1.1896174445644885 1.548065842052882 1.2118815853026585 1.0 15.30912036228146 -7.465352950802528 5.713953304790482 1.3008274365190493 1.0039104278295747 0.4066094155209342 0.1373764276707439 0.16791997933120975 11.745454194625434 0.056301739229343735 0.036799123863878354 3.424893325861749e-08 7.465352950802528 -0.29691700868947457 EDEEESLNEVGYDDIGGCRK ddPTM_A459_Selumetinib_30min_R2 1 EDEEESLNEVGYDDIGGCRK 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 167.95 1.2857e-08 0.0 7551.2 7403.3 7506.1 9118.3 6915.7 5904.0 5796.8 6362.4 4086.5 5243.0 False True 7131.534533848639 7971.109304638552 7023.165698023758 7876.371810055144 6046.88793885757 6717.222408824144 6066.362686141285 6380.913530647975 4903.914186350059 5091.620967050029 1.4006412849659722 1.5655347002895295 1.3793575255254755 1.546928151373871 1.1876154918029966 1.3192699245081378 1.1914403537496623 1.25321848816742 0.9631341802709397 1.0 12.313909310085489 -7.23644549607606 0.479687358431563 0.9797032641265909 1.5134771874815987 0.7461224975313274 0.09752609769010225 0.4824287398056992 0.24359947229806506 0.0917070999653412 0.08847219576379603 5.801689791160723e-08 7.23644549607606 0.5337739233550077 EDEGPPGYPEPLAPGHGS(ph)PFPSLSK ddPTM_A459_Selumetinib_30min_R2 1 EDEGPPGYPEPLAPGHGSPFPSLSK 25 0 B1AKB5;B0QYS6;B0QYS7;P19484-2;P19484 B1AKB5 TFEB Transcription factor EB 1 EDEGPPGYPEPLAPGHGS(0.914)PFPS(0.077)LS(0.009)K 96.579 4.4975e-06 4946300.0 19789.0 13626.0 17273.0 17549.0 21101.0 19880.0 21754.0 23376.0 17455.0 20306.0 True False 18689.206601643546 14671.070385504427 16161.673985420426 15158.795926286444 18450.103734666558 22618.28954732791 22765.60410473324 23444.020289894866 20946.48773344924 19719.713018675928 0.9477423218047635 0.7439799134809879 0.8195694313661769 0.7687128059079774 0.9356172535164704 1.146988778483076 1.1544591994403084 1.1888621435662763 1.0622105764729677 1.0 14.267350935852205 -6.591587004594533 3.4142435865939507 1.125002396190219 0.8162025694601404 0.7867098679930432 0.07126284029816313 0.09772680871057722 2.304135099131979 0.02368206507812255 0.024087230891620504 2.561020149485064e-07 6.591587004594533 -0.30879982673007855 EDEGPPGYPEPLAPGHGSPFPS(ph)LSK ddPTM_A459_Selumetinib_30min_R2 1 EDEGPPGYPEPLAPGHGSPFPSLSK 25 0 B1AKB5;B0QYS6;B0QYS7;P19484-2;P19484 B1AKB5 TFEB Transcription factor EB 1 EDEGPPGYPEPLAPGHGS(0.392)PFPS(0.449)LS(0.159)K 74.859 0.00021081 4818100.0 15134.0 11932.0 13306.0 16315.0 17350.0 14962.0 16317.0 16097.0 12876.0 16386.0 True False 14292.912866202098 12847.146032572935 12449.9064464774 14092.868855055183 15170.337889032031 17022.879688486937 17075.772831522117 16143.839604998202 15451.559785499416 15912.89360405907 0.8981969729601066 0.8073419173302256 0.7823785388285177 0.8856257828218222 0.9533362232223039 1.0697538808494722 1.0730777981929331 1.0145131367484428 0.9710088039272771 1.0 13.957908579055575 -6.313236709654171 2.288902565954461 1.0284294104840472 0.8290867863300252 0.8094968513184768 0.04179132393394145 0.12751894574546146 1.311785967221931 0.014788864031958525 0.018249472108469444 4.861421645396797e-07 6.313236709654171 -0.19934262415402204 EDEGPPGYPEPLAPGHGSPFPSLS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 EDEGPPGYPEPLAPGHGSPFPSLSK 25 0 B1AKB5;B0QYS6;B0QYS7;P19484-2;P19484 B1AKB5 TFEB Transcription factor EB 1 EDEGPPGYPEPLAPGHGS(0.04)PFPS(0.406)LS(0.554)K 58.627 0.032966 0.0 736.81 978.53 578.76 794.9 881.57 899.33 900.09 748.83 465.39 1001.0 True False 753.976239417314 863.9632526937446 500.16757090111736 656.0856371210232 801.8321491538247 890.2835567263071 832.1954866333837 728.9685958573554 789.7328392592555 1129.48810056569 0.6675380103957663 0.764915763398516 0.4428267731644226 0.5808698974273663 0.7099075667572213 0.7882186242426279 0.7367899548623743 0.6453973224616183 0.6991953601491929 1.0 10.141453356326862 -6.419110459088138 4.5829205678118425 0.749476882145414 0.6134688894624545 0.28609947721406126 0.11575398826002885 0.3541896534501061 12.13735479298092 0.03714810841080514 0.04194714209635705 3.809689148842554e-07 6.419110459088138 -0.1360079926829595 EDEIS(ph)PPPPNPVVK ddPTM_A459_Selumetinib_30min_R1 4 EDEISPPPPNPVVK 14 0 K7EIE5;K7EID3;K7EJ40;K7EK41;K7EPB2;P10644-2;P10644;K7EMU2;K7EMZ6 K7EIE5 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 EDEIS(1)PPPPNPVVK;EDEIS(1)PPPPNPVVK;EDEIS(1)PPPPNPVVK;EDEIS(1)PPPPNPVVK 196.97 0.00011051 195566000.0 26282.6 31556.4 17901.7 19151.0 21686.100000000002 20588.800000000003 26266.800000000003 23801.8 12416.5 24477.5 True False 26894.933442962898 27861.762017827656 15470.747466999324 15806.637358793208 19724.59608399192 20381.695365134685 24285.474128478014 23170.498944857456 21069.893634720436 27619.425556040656 0.9737687479557552 1.008774131138075 0.5601400882001947 0.5723014523499433 0.7141566374713375 0.7379478376108729 0.879289617345663 0.8389203786242334 0.7628650201999668 1.0 14.753395693494808 -9.950593873565781 10.126231067645314 0.9999995253742022 0.7781188345767052 0.17303120507405212 0.14185421695856718 0.0 0.0 0.15130740280585686 0.036697435512142704 1.1204852049833697e-10 9.950593873565781 -0.22188069079749706 EDEIS(ph)PPPPNPVVK ddPTM_A459_Selumetinib_30min_R2 4 EDEISPPPPNPVVK 14 0 K7EIE5;K7EID3;K7EJ40;K7EK41;K7EPB2;P10644-2;P10644;K7EMU2;K7EMZ6 K7EIE5 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 EDEIS(1)PPPPNPVVK;EDEIS(1)PPPPNPVVK;EDEIS(1)PPPPNPVVK;EDEIS(1)PPPPNPVVK 157.68 4.8033e-05 183709000.0 201988.0 139735.0 183224.0 194127.0 203734.0 175234.0 202095.0 216461.0 174461.0 154970.0 True False 190762.31558202926 150452.22518115825 171435.56731920765 167686.56771224647 178139.11351493082 199370.89288412774 211492.81794364518 217090.8656729524 209358.07484762446 150495.6134395846 1.267560636633502 0.999711697521046 1.1391399616310363 1.1142289391681377 1.183683095098606 1.3247621530455025 1.4053088532613442 1.4425062678660865 1.3911241003158528 1.0 17.19936191118135 -6.68818661893966 2.899392548264747 1.3494668022870153 1.1229956962876495 0.2879188167736526 0.13123899672802697 0.26516042363706155 4.5214613930662395 0.044931020161790264 0.043546744667194215 2.0502809714974654e-07 6.68818661893966 -0.22647110599936582 EDEKGDDVDDPENQNSALADTDASGGLTKES(ph)PDTNGPK ddPTM_A459_Selumetinib_30min_R1 1 EDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPK 38 2 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EDEKGDDVDDPENQNS(0.005)ALADT(0.07)DAS(0.07)GGLT(0.201)KES(0.583)PDT(0.07)NGPK 88.927 5.0378e-10 9442500.0 1193.4 1234.8 1736.8 1143.3 936.8 1276.8 1269.4 1359.2 912.35 1262.3 True False 1221.2038980478317 1090.2290419570534 1500.9520995595076 943.6441173990012 852.066605405473 1263.9565512416445 1173.6481360001962 1323.1496006961763 1548.1913145924543 1424.3285008432285 0.8573892169712651 0.7654337052945426 1.053796296760836 0.6625185951417434 0.5982233767709022 0.8874052232286015 0.8240010189400655 0.9289637888400376 1.0869622518091133 1.0 10.476066206163791 -7.92338381477531 2.2340444187891952 1.0437138350132533 0.8010909279415481 0.3912062689526258 0.11872375429686467 0.344581625419545 3.2724480247218306 0.09568210624167182 0.034893234885975934 1.1929333642986005e-08 7.92338381477531 -0.2426229070717052 EDEKGDDVDDPENQNSALADTDASGGLTKES(ph)PDTNGPK ddPTM_A459_Selumetinib_30min_R2 1 EDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPK 38 2 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EDEKGDDVDDPENQNSALADT(0.005)DAS(0.13)GGLT(0.231)KES(0.612)PDT(0.022)NGPK 108.09 5.8343e-19 18371000.0 33823.0 30330.0 27507.0 25415.0 20873.0 16439.0 26120.0 26242.0 10585.0 26345.0 True False 31943.253064196757 32656.213473678916 25737.22956735714 21953.4331566796 18250.74713301242 18703.32303161587 27334.631755798106 26318.359875403035 12702.29576961101 25584.35139746957 1.2485465262705904 1.276413576656424 1.005975456149445 0.8580805045873046 0.7133558654458412 0.7310454246444461 1.0684121450310304 1.0286897434502116 0.4964869178144315 1.0 14.642974038829973 -5.446951463893169 2.5234778236820197 0.8428998296444195 1.2702448763334344 0.515331469709164 0.16163626851076537 0.23739100435476107 2.9240747210037537 0.046245600676323904 0.11614882083665022 3.5731276866539586e-06 5.446951463893169 0.42734504668901496 EDEVEEWQHR ddPTM_A459_Selumetinib_30min_R2 4 EDEVEEWQHR 10 0 P15311;E7EQR4 P15311 EZR Ezrin 0 ;;; 134.57 0.0029223 42379800.0 275842.0 242031.0 322420.0 363943.0 385746.0 292273.0 263585.0 295496.0 282872.0 307074.0 False True 260511.80592301572 260593.99944767496 301675.84822435264 314373.335563307 337285.1388670057 332530.95275986753 275842.2247837689 296355.84443800396 339454.3041040527 298207.97574593226 0.8735910073209008 0.8738666321577404 1.0116290400005095 1.0542083416009882 1.1310399663970305 1.1150974481084228 0.9249994876689059 0.9937891288678802 1.1383139678103766 1.0 18.185959318293 -5.333090677786131 3.1009888171682713 1.0509022832133428 0.8686240448354555 0.5491278062492269 0.06328153023740207 0.19947326592626635 3.7130203514708175 0.01834633559644487 0.04756376881819577 4.644182976613763e-06 5.333090677786131 -0.18227823837788726 EDFDSTSSSSS(ph)TPPLQPR ddPTM_A459_Selumetinib_30min_R1 1 EDFDSTSSSSSTPPLQPR 18 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 EDFDSTSSSSS(0.5)T(0.5)PPLQPR 281.49 4.5090999999999986e-67 19322000.0 1263.7 1686.9 848.33 975.3 1353.9 1033.3 1575.8 1208.1 787.62 1468.0 True False 1293.1417512678433 1489.3969637814666 733.1314455431345 804.9821636484261 1231.4399840504595 1022.9059401613343 1456.936137316142 1176.057263538148 1336.5336145112167 1656.4320995309035 0.7806789977289483 0.8991596843621054 0.4425967389491879 0.4859735354539402 0.7434291960408154 0.6175356903859918 0.8795628494091258 0.7099942484036645 0.8068749783886214 1.0 10.693863350334082 -7.258500475247804 24.87772806355164 0.824940874694869 0.6581491197909081 0.2854434423497948 0.14328204243057904 390.6393765956801 3306770.895552461 0.05995339517781192 0.044365570259475046 5.514415989396935e-08 7.258500475247804 -0.16679175490396092 EDFDSTSSSSS(ph)TPPLQPR ddPTM_A459_Selumetinib_30min_R2 1 EDFDSTSSSSSTPPLQPR 18 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 EDFDS(0.007)T(0.015)S(0.034)S(0.017)S(0.053)S(0.074)S(0.47)T(0.33)PPLQPR 124.04 0.00087447 25522000.0 38915.0 20440.0 32718.0 40381.0 44905.0 36044.0 38788.0 45689.0 38776.0 27145.0 True False 36752.2600890878 22007.682275041116 30612.959500664932 34881.03813888959 39263.63244420652 41008.733825145246 40591.718856963904 45821.94742577886 46532.28349196373 26361.253318819956 1.3941772663308631 0.8348496184485008 1.1612861926716351 1.3231934656910698 1.489444829096014 1.5556443136134233 1.5398250745530548 1.7382309889289456 1.765177206454868 1.0 14.68613134298578 -6.04927042883215 1.8104918352836483 1.5644642799708677 1.0932458216561918 0.34277448007622935 0.23466998745369697 0.33253531952879734 2.1790832981484165 0.07503394019475351 0.11756273354026954 8.927494086008565e-07 6.04927042883215 -0.4712184583146759 EDFDSTSSSSST(ph)PPLQPR ddPTM_A459_Selumetinib_30min_R1 1 EDFDSTSSSSSTPPLQPR 18 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 EDFDSTSSSSS(0.027)T(0.972)PPLQPR 187.75 4.687099999999999e-10 12060000.0 1750.2 2244.6 1153.7 1515.5 1451.2 1537.0 2035.5 1888.2 922.9 1785.1 True False 1790.9762547036319 1981.801188513769 997.0338768204765 1250.8463744583096 1319.9392162301704 1521.5391754843422 1881.9605962095488 1838.1188022620083 1566.093894050941 2014.2349733464673 0.889159546131844 0.9838977153798434 0.4949938264471676 0.6210032051921642 0.6553054800936219 0.7553930875087745 0.9343302152493377 0.9125642373333147 0.7775130085488582 1.0 10.976016277395049 -7.168851762932023 4.989589683656508 0.8983650836482008 0.7228050589142399 0.27397736067876766 0.13763635977067265 0.34606256062943264 14.096410371713873 0.05861457895394449 0.044871514793781514 6.778728454237443e-08 7.168851762932023 -0.17556002473396093 EDFDSTSSSSST(ph)PPLQPR ddPTM_A459_Selumetinib_30min_R2 1 EDFDSTSSSSSTPPLQPR 18 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 EDFDSTSSSSS(0.036)T(0.964)PPLQPR 163.9 8.8812e-06 24271000.0 49627.0 43319.0 51566.0 55986.0 66030.0 56576.0 54075.0 63314.0 58743.0 45078.0 True False 46868.93001262137 46641.42800746118 48248.299700815725 48360.610218763046 57734.721084310295 64368.830454206436 56589.59464757973 63498.23325780302 70493.24141655731 43776.48101329032 1.070641790471742 1.0654448902208717 1.1021511684817193 1.104716713161138 1.3188524922042573 1.4703975505629239 1.2926940068663677 1.4505102234810805 1.610299407007062 1.0 15.417868367217677 -6.3120413149073995 3.148493167992734 1.389336998317952 1.0805260922952897 0.44206194724423165 0.1487982228964711 0.2185687386238009 4.345438461905539 0.04597140620418963 0.05513999917230753 4.874821131927452e-07 6.3120413149073995 -0.30881090602266226 EDGGT(ph)VGVFSPK ddPTM_A459_Selumetinib_30min_R2 1 EDGGTVGVFSPK 12 0 O43896 O43896 KIF1C Kinesin-like protein KIF1C 1 EDGGT(0.908)VGVFS(0.092)PK 126.5 0.0063754 8241600.0 58416.0 62230.0 58729.0 51813.0 56756.0 46425.0 58111.0 59577.0 38326.0 60945.0 True False 55169.47257777604 67002.84089901211 54950.44007930041 44755.9800175896 49625.80387492231 52819.62234580975 60813.27664476203 59750.359206496694 45992.27091791324 59185.35949587334 0.9321472919603149 1.1320847160467757 0.9284465034487421 0.7562001886752109 0.8384810753473997 0.8924440570390143 1.0275054027339683 1.0095462748800699 0.7770886467475124 1.0 15.85295272440874 -5.500557451415561 23.959084636759414 0.8983238723109468 1.0316534715739287 0.2165156288877217 0.09894296042158977 664.5004247210651 713254.448949344 0.026880396202998987 0.0551693536041052 3.158221229893095e-06 5.500557451415561 0.13332959926298193 EDGGTVGVFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EDGGTVGVFSPK 12 0 O43896 O43896 KIF1C Kinesin-like protein KIF1C 1 EDGGT(0.025)VGVFS(0.975)PK 109.55 0.0075911999999999985 9525400.0 52094.0 47372.0 46457.0 51486.0 53321.0 41602.0 48196.0 52683.0 37823.0 53944.0 True False 49198.82402880486 51005.28007501211 43468.00719855713 44473.51798169607 46622.33928421191 47332.29787464463 50437.20949856223 52836.29880785984 45388.65686291896 52386.496556655824 0.9391508740348097 0.9736341123680616 0.8297559496376441 0.8489500330223096 0.889968643613913 0.9035209640991149 0.9627902763838111 1.0085862250917574 0.8664190172334062 1.0 15.67690736189721 -7.219278356759075 4.874522784446715 0.9603484485932968 0.8947458682421031 0.25230302530503423 0.05224536435335502 0.30588344494778236 17.57847124224697 0.021684648688764928 0.016206202175671713 6.035616584928204e-08 7.219278356759075 -0.0656025803511937 EDGKEDISDPMDPNPCS(ph)ATYSNLGQSR ddPTM_A459_Selumetinib_30min_R1 1 EDGKEDISDPMDPNPCSATYSNLGQSR 27 1 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 EDGKEDISDPMDPNPCS(0.295)AT(0.295)Y(0.258)S(0.115)NLGQS(0.036)R 64.845 0.00074571 3747400.0 678.81 855.43 582.06 663.09 551.47 580.8 660.69 653.22 407.26 681.93 True False 694.6249522656682 755.2758579213822 503.01944902671977 547.2937792408848 501.5896358699363 574.9576793242071 610.8536213754294 635.8944836424046 691.090474906475 769.4623580607007 0.9027406538980705 0.9815631005328537 0.6537284686602408 0.7112677748398841 0.6518702709955921 0.7472200209680047 0.793870700725351 0.8264140240012113 0.8981472162566227 1.0 9.587706941711641 -8.39767007919355 1.4009001301133204 0.9976241726023687 0.771381904393758 0.35054557646306383 0.09707611200155032 0.5017648573694423 2.081645465480996 0.10224111725377977 0.0310866709918705 4.002486915146389e-09 8.39767007919355 -0.2262422682086107 EDGKEDISDPMDPNPCS(ph)ATYSNLGQSR ddPTM_A459_Selumetinib_30min_R2 1 EDGKEDISDPMDPNPCSATYSNLGQSR 27 1 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 EDGKEDISDPMDPNPCS(0.409)AT(0.3)Y(0.258)S(0.012)NLGQS(0.021)R 90.268 4.2616000000000013e-05 4123100.0 53172.0 47692.0 49193.0 56570.0 57071.0 58708.0 67474.0 73642.0 57460.0 61638.0 True False 50216.91310438076 51349.82304604994 46027.97593728869 48865.068411306886 49901.230758786594 66794.49410183741 70611.67469719457 73856.28602791054 68953.60556654222 59858.350785243136 0.838929112573558 0.8578556270332326 0.768948280957917 0.8163450507786723 0.8336552895989365 1.1158759509008096 1.1796461775322158 1.2338510008885561 1.151946297583951 1.0 15.869264909860101 -6.785020783737809 4.216517516378173 1.1590093638209866 0.8190060262612989 0.8718257981142428 0.059938112960284444 0.06460446567052291 2.5861008647592127 0.020775502435435304 0.019064848001428575 1.6405112624810296e-07 6.785020783737809 -0.3400033375596877 EDGKEDISDPMDPNPCSATY(ph)SNLGQSR ddPTM_A459_Selumetinib_30min_R1 1 EDGKEDISDPMDPNPCSATYSNLGQSR 27 1 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 EDGKEDISDPMDPNPCS(0.309)AT(0.214)Y(0.441)S(0.032)NLGQS(0.004)R 70.50399999999998 0.0056702 5264600.0 1025.5 1129.6 850.43 971.6 746.93 911.39 987.82 852.49 573.78 1027.6 True False 1049.39215472436 997.3459068632066 734.946277077609 801.9282991908243 679.3703133812023 902.222244075911 913.3079421015558 829.8791959222212 973.6627527668743 1159.5024696716328 0.9050365843735928 0.8601498771672746 0.6338462368999899 0.6916141363786209 0.5859153655563991 0.7781115328986038 0.7876722697798147 0.7157200761782252 0.8397246045043891 1.0 10.179290177504324 -8.593260726327749 2.7883381510289347 0.9998518378065987 0.7404547087611332 0.4237356325521837 0.09142942821733573 0.3455468997077159 6.489207055447987 0.09472484734708166 0.025384419314102964 2.551169262254128e-09 8.593260726327749 -0.2593971290454655 EDGNEEDKENQGDETQGQQPPQR ddPTM_A459_Selumetinib_30min_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 95.307 0.00022187 13809000.0 1536.6 1828.8 1609.0 1439.5 1611.9 1816.5 1734.8 1767.6 1223.3 1738.9 False True 1572.399790296881 1614.6832458139459 1390.5066376043562 1188.1183477616223 1466.103929604058 1798.2276592500377 1603.9426393045076 1720.7175060260158 2075.850753703019 1962.104753320359 0.8013842215284367 0.8229342715171087 0.7086811421517024 0.605532577071146 0.7472098149311617 0.9164789271352606 0.8174602485368052 0.8769753516544634 1.0579714208378397 1.0 10.938186351225111 -7.674739844513705 0.8954772152799373 1.0243160567989351 0.7408908336797512 0.6478046460630418 0.07582418093271712 0.40770348517366606 0.5984882561880172 0.07320705074031168 0.03249768768717995 2.114755462756681e-08 7.674739844513705 -0.28342522311918394 EDGNEEDKENQGDETQGQQPPQR ddPTM_A459_Selumetinib_30min_R2 2 EDGNEEDKENQGDETQGQQPPQR 23 1 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 ; 166.34 1.051e-11 31524000.0 46128.0 35307.0 43892.0 45064.0 41810.0 38440.0 47160.0 41057.0 28225.0 37658.0 False True 43564.390425014564 38014.93337010163 41068.03650599626 38926.20546026398 36557.454013857605 43734.7610764228 49353.0334457672 41176.469072647764 33870.78867239214 36570.71569276556 1.1912370212003398 1.0394910969057618 1.122976013130647 1.0644091788437267 0.9996373688986738 1.195895684510064 1.3495233142382894 1.1259410239213152 0.9261724314324119 1.0 15.158401240199206 -8.250716674872251 22.06704693158443 0.9630862337806007 1.134642198569268 0.35173249312241317 0.09395671322672608 158.24423810035324 325671.0854432495 0.07132936645461718 0.02617122931362919 5.614141120490117e-09 8.250716674872251 0.17155596478866741 EDGNEEDKENQGDETQGQQPPQRR ddPTM_A459_Selumetinib_30min_R1 1 EDGNEEDKENQGDETQGQQPPQRR 24 2 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 85.054 7.013100000000001e-05 14589000.0 2256.7 1533.4 3766.0 3796.9 2630.8 2377.3 1843.5 2017.2 1552.0 1642.8 False True 2309.276719226195 1353.8688151416795 3254.597885157246 3133.8426916402236 2392.844604505466 2353.3865204156987 1704.4433107896352 1963.6973032109536 2633.630646404874 1853.6693822270888 1.2457867305612595 0.730372324278818 1.7557596388882537 1.6906157709068228 1.2908691417401446 1.2695826682901916 0.9194969324798545 1.0593568206060953 1.4207661148509134 1.0 10.856168234582562 -7.043774998486289 6.8758416064546095 1.1025447715718373 1.3445452364006398 0.1377542223343614 0.2873895600977556 0.5326035214630475 67.58045453813288 0.11754425723850706 0.09233766727746727 9.041177623748282e-08 7.043774998486289 0.24200046482880255 EDGNEEDKENQGDETQGQQPPQRR ddPTM_A459_Selumetinib_30min_R2 2 EDGNEEDKENQGDETQGQQPPQRR 24 2 H0Y449;P67809 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 ; 76.176 0.00025123 10129700.0 31014.0 40082.0 32571.0 41363.0 34164.0 20251.6 14762.5 17496.6 11160.5 35914.0 False True 29290.36603887882 43156.16051605666 30475.41732062346 35729.28804484509 29872.012889964866 23041.07407427898 15448.985501338804 17547.512209281944 13392.91185042452 34877.06950422178 0.8398172912816915 1.2373792044320904 0.8737952400769936 1.0244349239410768 0.8564943475640617 0.6606367565225031 0.4429553778728097 0.5031246162226406 0.3840033592502186 1.0 15.089991204373591 -6.713183776243166 2.132839741375557 0.5408343795527681 1.002777154353363 0.4998537063466393 0.1866874142141782 0.22486647826671022 2.1016157817131975 0.0682317509357149 0.06485727094410147 1.93560272012828e-07 6.713183776243166 0.46194277480059487 EDGRS(ph)SSGPPHETAAPK ddPTM_A459_Selumetinib_30min_R2 1 EDGRSSSGPPHETAAPK 17 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 EDGRS(0.465)S(0.465)S(0.069)GPPHETAAPK 75.911 0.011866 6489600.0 8694.9 8011.4 11357.0 12068.0 12878.0 9663.4 7769.5 6157.4 8469.6 10175.0 True False 8211.672266442494 8625.848619288869 10626.302984566659 10424.317581538831 11260.150509219284 10994.445634388754 8130.7971449721845 6175.317014587557 10163.756660396537 9881.22131217509 0.8310381892089118 0.8729536913276681 1.0754038037255091 1.0549624638701867 1.1395504820183668 1.1126606000456656 0.8228534599213834 0.6249548329596338 1.0285931606322107 1.0 13.270473653610104 -7.278617345359449 23.865475658849288 0.8378465637541319 1.0182990054263963 0.19509988092919905 0.1387907672973577 652.9986435970582 907210.4594849619 0.060277178007326064 0.04077395740023156 5.2648094174722396e-08 7.278617345359449 0.18045244167226437 EDGRSSS(ph)GPPHETAAPK ddPTM_A459_Selumetinib_30min_R2 1 EDGRSSSGPPHETAAPK 17 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 EDGRS(0.214)S(0.138)S(0.648)GPPHETAAPK 60.631 0.02536 3651400.0 80036.0 71167.0 87834.0 107100.0 108220.0 70338.0 62105.0 65861.0 58294.0 91695.0 True False 75587.91952949323 76625.28006202803 82182.85606642855 92512.7952421948 94624.43610092484 80026.42103520874 64993.005558722834 66052.64460612448 69954.42887044909 89047.52709777847 0.8488491706961616 0.860498686031896 0.9229100318101795 1.0389148161364583 1.062628454544534 0.8986933567210225 0.7298687305191237 0.7417684326437892 0.7855853065255339 1.0 16.442287926942498 -7.056605617651573 6.537471701875082 0.7946767958864589 0.9491457656063217 0.29670277068355166 0.09424966174972618 0.26908909536061265 24.8947450969618 0.0376179903228426 0.029371140520439716 8.777975863550807e-08 7.056605617651573 0.1544689697198628 EDGSGDRGDGPFR ddPTM_A459_Selumetinib_30min_R1 1 EDGSGDRGDGPFR 13 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 100.09 0.031605 19162000.0 3224.2 3891.8 3779.6 3988.3 3707.5 3315.3 3560.3 3399.3 1943.5 2887.9 False True 3299.317586798908 3436.1462467512674 3266.351079856695 3291.8182746632 3372.1572796122878 3281.951092051553 3291.7437045860256 3309.1395215174466 3297.9775523762087 3258.590095528131 1.0124985009089265 1.054488642639282 1.0023817000914643 1.010197103090895 1.0348516323792947 1.007169050367974 1.010174218937016 1.0155126679046518 1.0120872695532128 1.0 11.670032168698716 -1.5228787870784166 0.09960732001615706 0.9918800629883898 1.098113150119167 0.18798469076915836 0.01410929902426084 209.67832500800145 1.4867613577541903 0.18168070441119322 3.0433901752802703 0.029999997112691128 1.5228787870784166 0.10623308713077717 EDGVLGSRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 EDGVLGSRSPR 11 1 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;D6RFZ4;P78312-3;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 EDGVLGS(0.038)RS(0.962)PR;EDGVLGS(0.132)RS(0.868)PR 92.906 0.01339 11735200.0 6796.6 6797.700000000001 9750.0 11162.400000000001 9251.8 7594.9 6582.299999999999 5849.3 4111.9 4489.3 True False 6954.947556118561 6001.822123835003 8426.003552916394 9213.096384198903 8414.97632353795 7518.502201617452 6085.791811559867 5694.15756279587 6977.593978706318 5065.545384485073 1.3729908683515923 1.1848323661688218 1.6633951358374657 1.818776792014754 1.661218227224186 1.4842433797247934 1.2014089993546677 1.124095656162934 1.3774615464067372 1.0 12.3065018905362 -7.2276509542439165 4.011249052919038 1.1823864916750761 1.5446806215816864 0.4748672569013328 0.18360300582769742 0.22898759917284903 8.260779324044062 0.08412732300898844 0.0611819563790738 5.9203726783953144e-08 7.2276509542439165 0.36229412990661025 EDGVLGSRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 EDGVLGSRSPR 11 1 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;D6RFZ4;P78312-3;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 EDGVLGS(0.182)RS(0.818)PR;EDGVLGS(0.005)RS(0.995)PR 110.54 0.004818899999999999 6946200.0 49805.0 66992.0 63368.0 72110.0 69341.0 43671.0 31749.0 26811.0 28798.0 68439.0 True False 47037.03748521186 72130.07098676887 59290.97186986173 62288.493603311676 60629.76366359488 49686.28384413264 33225.391409449985 26889.0155712 34558.4046833498 66462.98824412297 0.7077177648474321 1.0852667460847583 0.8920900705228909 0.937190686860511 0.9122334891247702 0.747578241014858 0.4999081787808113 0.4045712701396281 0.5199646539576958 1.0 16.020263539086457 -6.9923063156052825 3.0571357821722547 0.5583277929453735 0.9174877694993032 0.3898764191096802 0.17268675741145897 0.2174112575939329 4.173427548016559 0.06510348877609738 0.05301624082574848 1.0178732107730794e-07 6.9923063156052825 0.3591599765539297 EDIDVSILPQLEHCS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 EDIDVSILPQLEHCSSR 17 0 A0A140T9S4;A0A0G2JKF9;Q9UBS5-2;Q9UBS5-3;Q9UBS5-4;Q9UBS5 A0A140T9S4 GABBR1 Gamma-aminobutyric acid type B receptor subunit 1 1 EDIDVS(0.001)ILPQLEHCS(0.686)S(0.313)R 81.65100000000002 0.038667 0.0 14464.0 13075.0 13136.0 12059.0 10502.0 8706.2 10294.0 10303.0 9813.8 13336.0 True False 13660.148783979601 14077.810457248657 12290.844061395404 10416.543397064697 9182.644870928783 9905.400022985226 10772.691397174023 10332.98002424653 11776.83422048261 12950.955028910776 1.0547599581255338 1.087009446471119 0.9490299390244359 0.80430696993477 0.7090322567277942 0.7648393497524413 0.8318067179698985 0.7978546756729471 0.9093409863745845 1.0 13.66077086855555 -5.536675804473321 2.9907863860068113 0.8149798223271892 1.068842474066134 0.6073023951802863 0.07663308017642725 0.15431239403275937 2.801838569251947 0.02127540271996945 0.04510839130631335 2.9061912812350214e-06 5.536675804473321 0.25386265173894473 EDIFYTS(ph)K ddPTM_A459_Selumetinib_30min_R1 3 EDIFYTSK 8 0 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 1 EDIFYT(0.012)S(0.988)K;EDIFYT(0.211)S(0.789)K;EDIFYT(0.016)S(0.984)K 132.88 0.0032035 22581800.0 14408.8 29139.3 20459.6 20038.4 21311.4 20230.6 28648.2 31998.0 9820.5 26979.8 True False 14744.497005355788 25727.657209506964 17681.298696538273 16539.069607354268 19383.78763283328 20027.098531915126 26487.243209201853 31149.309095847755 16664.67123905869 30442.920135506727 0.4843325456206392 0.8451113459217674 0.5808016648151931 0.5432813124935452 0.6367256342871404 0.6578573422907865 0.8700625002891488 1.0232037188678604 0.5474071201081021 1.0 14.893819130735038 -7.219730674962104 4.716774976119581 0.8629083854034211 0.6273152730397408 0.3761799940560525 0.14886031930324173 0.2271295408007323 12.022831568248915 0.05733292392010234 0.042701361803339215 6.029333755659361e-08 7.219730674962104 -0.2355931123636803 EDIFYTS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 EDIFYTSK 8 0 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 1 EDIFYT(0.015)S(0.985)K;EDIFYT(0.019)S(0.981)K 130.98 0.0036835 23275000.0 237280.0 199817.0 212995.0 192037.0 206317.0 155989.0 225955.0 248780.0 170607.0 177179.0 True False 224092.92750709917 215142.32138707838 199291.13359142197 165881.22931769717 180397.61396261773 177475.06882284355 236462.3552213385 249503.9086122537 204733.16715786693 172063.38190367253 1.302385929113928 1.2503666904996849 1.1582425696072425 0.9640704924105447 1.0484369885488536 1.0314517061056063 1.3742747155447572 1.4500697699405631 1.1898706447167484 1.0 17.392580573749733 -7.262966769029113 24.998934956221927 1.2910595962044615 1.1220899943616287 0.1340519351815982 0.14698390119875193 221.87005781232403 3631332.1598717314 0.06155162624838917 0.04402340937475065 5.4579962251865866e-08 7.262966769029113 -0.16896960184283283 EDIFYTSK ddPTM_A459_Selumetinib_30min_R2 2 EDIFYTSK 8 0 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 ; 140.5 0.032375 22286800.0 133262.0 111457.0 117674.0 136617.0 118101.0 93363.0 107300.0 108759.0 89426.0 106627.0 False True 125855.83153005315 120005.3935092591 110102.98295376386 118009.52892252985 103264.09654366408 106222.90578506919 112289.66261091632 109075.47068397843 107313.69877120796 103548.40145978334 1.2154299801425104 1.1589304307692998 1.0632996878906549 1.1396557287112055 0.9972543765803118 1.0258285428609402 1.0844171520554853 1.0533766735775416 1.0363626792721372 1.0 16.65994575639848 -3.39430245826123 0.5231602420414377 1.035686068446391 1.9347816253400134 0.7224486450206138 0.03617846537049226 8.781135438350082 0.5910974540322907 0.01958573236987035 6.639901294100077 0.00040336437769762537 3.39430245826123 0.8990955568936223 EDILENEDEQNS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 EDILENEDEQNSPPK 15 0 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 EDILENEDEQNS(1)PPK;EDILENEDEQNS(1)PPK 297.49 1.9803999999999997e-80 4080700.0 3405.7400000000002 5374.0 3591.0 3541.1200000000003 2750.8199999999997 4418.3 3713.64 3779.3199999999997 2317.25 3858.13 True False 3485.0871155835616 4744.809581695178 3103.3619239510545 2922.7298670549726 2502.0088166967166 4373.855913495424 3433.5171449312843 3679.080156638518 3932.204004756247 4353.358566868637 0.8005513586927847 1.0899193137467909 0.7128661414589832 0.67137356644557 0.5747307000480796 1.0047083984266267 0.7887053391517452 0.845113054697186 0.9032575526129183 1.0 12.08791313808417 -8.506599248390932 0.9552836337147752 0.9997782662639796 0.8015622431247789 0.15929668395928998 0.1415596391503199 1.2281135153328657 2.477346174407623 0.14316202850327892 0.0486887702126731 3.114589044251797e-09 8.506599248390932 -0.19821602313920073 EDILENEDEQNS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 EDILENEDEQNSPPK 15 0 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 EDILENEDEQNS(1)PPK;EDILENEDEQNS(1)PPK 233.14 3.6041e-14 7093400.0 59465.0 49085.0 53570.0 51947.0 50241.0 39909.0 53061.0 47871.0 43613.0 43367.0 True False 56160.17335725574 52849.66166684902 50123.36452260594 44871.72898642671 43929.27641976126 45406.10249216847 55528.44163837682 48010.29668452935 52336.818649035915 42114.882029002205 1.3334994816934622 1.2548927866034234 1.1901580179682976 1.0654601609836165 1.043082024769999 1.0781486330865129 1.3184992801389646 1.1399841189503344 1.2427155467987403 1.0 15.362042504421945 -5.174343804387548 2.1633700810071668 1.1355699447736174 1.3262815509326766 0.3558977450714842 0.09038924042667885 0.4402897842180087 3.6599833424838586 0.0260654194854743 0.11636931758181372 6.693545125798655e-06 5.174343804387548 0.19071160615905924 EDILENEDEQNS(ph)PPKK ddPTM_A459_Selumetinib_30min_R1 1 EDILENEDEQNSPPKK 16 1 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 EDILENEDEQNS(1)PPKK 92.563 0.0054898 10936000.0 2215.1 3717.3 2547.0 2517.4 1989.0 2596.4 2699.2 2021.0 1283.0 2074.4 True False 2266.7075201657044 3282.0767878741162 2201.1313896695433 2077.7833474505774 1809.0953011864713 2570.282573342581 2495.597170861612 1967.3965148668135 2177.157293387534 2340.669446367101 0.9684013792224309 1.4021957662446323 0.9403854068697605 0.8876876445221502 0.7728965335085337 1.0980972034867449 1.06618949323877 0.8405272764680054 0.9301429968108694 1.0 11.1927054934568 -5.353540009319401 13.332660902073275 0.9382301323598858 1.185249585489405 0.34534813615347093 0.13391754415980905 1.1185161142068478 159.30779768710443 0.03439926137269037 0.07161750609881647 4.4305739600747184e-06 5.353540009319401 0.24701945312951912 EDILENEDEQNS(ph)PPKK ddPTM_A459_Selumetinib_30min_R2 3 EDILENEDEQNSPPKK 16 1 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 EDILENEDEQNS(1)PPKK;EDILENEDEQNS(1)PPKK;EDILENEDEQNS(1)PPKK 89.65899999999998 0.0066638 19384000.0 96295.0 76538.0 89577.0 87471.0 83226.0 67614.0 87560.0 88365.0 67623.0 73629.0 True False 90943.30939942716 82408.21849154115 83813.71334406333 75557.29890410877 72770.4058301198 76927.21476121878 91631.71349684842 88622.12752038684 81149.4895444879 71503.13945888364 1.2718785508952677 1.1525118912985386 1.1721682988795006 1.0566990411317028 1.0177232269915206 1.0758578622335058 1.2815061574959137 1.23941589405801 1.1349080635983988 1.0 16.125718966647867 -11.320346764430926 2.168991031849556 0.9443421641731525 1.153055582942334 0.23151617671885794 0.0850472745058362 4368792.916448015 2410760.5869734306 1277011.6428963856 0.025166720107521752 4.782480804490766e-12 11.320346764430926 0.20871341876918137 EDINAIEMEEDKR ddPTM_A459_Selumetinib_30min_R2 1 EDINAIEMEEDKR 13 1 P49756;H0YE46;P49756-2;P49756-3 P49756 RBM25 RNA-binding protein 25 0 113.54 0.006134399999999999 1903200.0 13656.0 12370.0 11743.0 11249.0 10362.0 9000.7 12748.0 12223.0 8137.1 11233.0 False True 12897.05418929932 13318.739224180954 10987.468164811682 9716.866794392632 9060.232922544661 10240.464724780404 13340.807259682777 12258.566906373426 9764.747369570307 10908.674103160964 1.1822751387872328 1.2209310772536175 1.0072230649578107 0.8907468224371112 0.830553084349574 0.938745133270877 1.2229540578003943 1.1237449015752803 0.895136042861599 1.0 13.413188139227518 -5.285752339005651 6.843057304743316 0.9900804258870962 1.2020051483331655 0.3766543979568582 0.10961336666912047 0.19532358166578848 39.111831119122826 0.032438357719531595 0.07132445774281965 5.179020868665616e-06 5.285752339005651 0.2119247224460693 EDITHTYK ddPTM_A459_Selumetinib_30min_R2 2 EDITHTYK 8 0 P21980-2;P21980 P21980-2 TGM2 Protein-glutamine gamma-glutamyltransferase 2 0 ; 111.74 0.016116 16142500.0 171446.0 132566.0 168094.0 173163.0 185183.0 148462.0 177794.0 186696.0 153641.0 141121.0 False True 161917.717672716 142733.38593312638 157279.0150469089 149577.90067716318 161918.65598297506 168911.2928961469 186061.77329212733 187239.25445081326 184373.49308821978 137046.4700536083 1.1814803957327675 1.0414962594607036 1.1476327335201428 1.0914392805495317 1.1814872423903917 1.2325110805851043 1.3576546205046054 1.3662464591577668 1.3453355859227796 1.0 17.064305643156942 -6.724950143081778 2.166204144655397 1.296607314054628 1.1135773696099167 0.2750812096389067 0.10590185173601523 0.3203426901697063 3.0885276919698583 0.038939908501868535 0.03673995660446078 1.883865344435065e-07 6.724950143081778 -0.1830299444447112 EDITQSAQHALR ddPTM_A459_Selumetinib_30min_R1 1 EDITQSAQHALR 12 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 216.84 7.1901e-08 7240100.0 4325.8 4686.2 5131.3 5710.3 6212.9 4432.7 5741.3 4777.5 1822.5 3179.8 False True 4426.582723458445 4137.5375254447235 4434.497644213322 4713.10330060659 5650.944291976583 4388.111062569578 5308.229118652855 4650.785180492927 3092.649389866551 3587.958303874908 1.2337330449681767 1.153173246460608 1.2359390128430903 1.3135892062949988 1.5749749058883156 1.2230106068486148 1.4794567464510655 1.2962205205869288 0.8619524330944884 1.0 11.808947409271985 -8.252100167016332 22.04072985233362 0.930976216691237 1.317014605685035 0.6064332024759347 0.12332618697833889 80.65199803713467 190346.48136594548 0.09045509907146972 0.03290289792832104 5.596285121659753e-09 8.252100167016332 0.38603838899379794 EDITQSAQHALR ddPTM_A459_Selumetinib_30min_R2 2 EDITQSAQHALR 12 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 ; 161.25 0.00067497 7838000.0 60357.0 53585.0 68471.0 78629.0 87156.0 61511.0 54901.0 62695.0 56676.0 72242.0 False True 57002.59956821465 57694.7971970684 64065.65040558802 67919.59455740935 76206.68409547402 69983.58190873673 57454.00528426766 62877.43207028405 68012.78365975188 70156.1857527422 0.8125099584107106 0.8223764815323257 0.9131860536343923 0.9681198290452182 1.0862432624837408 0.9975397202377309 0.8189442551332254 0.8962492957055659 0.9694481381792261 1.0 16.098282693107627 -5.367277505417582 2.791842836684701 0.9581590214943032 0.8129759412594878 0.4306602414944367 0.06578028224114305 0.29893803076772957 4.437412901764172 0.02046188154646577 0.05367031586998324 4.2926204931876905e-06 5.367277505417582 -0.1451830802348154 EDKLECSEELGDLVK ddPTM_A459_Selumetinib_30min_R2 1 EDKLECSEELGDLVK 15 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 93.716 0.034341 2467900.0 27845.0 18042.0 22226.0 24780.0 24729.0 17697.0 21894.0 20939.0 22982.0 18333.0 False True 26297.486372366686 19425.763385826423 20796.003357839094 21404.92125211569 21622.321939935042 20134.601112628865 22912.114382137977 20999.929023361954 27579.042170732188 17803.67865514556 1.4770816122749033 1.091109526413074 1.1680733943054349 1.2022751964201126 1.2144861946093277 1.1309236423905926 1.2869314721941465 1.1795275251888815 1.5490642526712526 1.0 14.119887745977334 -7.312784578445007 24.991514362071815 1.2688414629420337 1.205808593932886 0.009869992384471837 0.1590500545186333 1485.9393069712644 723252.6796288885 0.06288479759424752 0.04239695582588394 4.866485363846772e-08 7.312784578445007 -0.06303286900914773 EDKNGHDGDTHQEDDGEKS(ph)D ddPTM_A459_Selumetinib_30min_R1 2 EDKNGHDGDTHQEDDGEKSD 20 2 K7EQH5;Q08117;Q08117-2 K7EQH5 AES Amino-terminal enhancer of split 1 EDKNGHDGDTHQEDDGEKS(1)D;EDKNGHDGDTHQEDDGEKS(1)D 71.634 0.0037335 22340300.0 2834.3 2667.5 4317.1 3607.8999999999996 2689.3 3533.5 2141.41 2740.4 2577.8 2750.1 True False 2900.33367541224 2355.187859912893 3730.8615321328566 2977.847993670825 2446.053289834479 3497.9561981613037 1979.881719640917 2667.7156899262823 4374.33832493717 3103.1021232424628 0.9346562118238159 0.7589785209685376 1.2023005959708608 0.9596358338858798 0.7882606477928523 1.127244950129535 0.6380330524127639 0.8596931663785397 1.4096662472604606 1.0 11.599495461474278 -8.24107632030634 24.88544401266197 1.2048331666765648 0.9093620722140273 0.29612122314266953 0.18268377998641147 803.4540234235762 981894.9416737224 0.1201554719181719 0.04529444982616791 5.7401557928968666e-09 8.24107632030634 -0.2954710944625375 EDKNGHDGDTHQEDDGEKS(ph)D ddPTM_A459_Selumetinib_30min_R2 1 EDKNGHDGDTHQEDDGEKSD 20 2 K7EQH5;Q08117;Q08117-2 K7EQH5 AES Amino-terminal enhancer of split 1 EDKNGHDGDTHQEDDGEKS(1)D 46.46 0.039035 2847600.0 13128.0 12136.0 10607.0 9932.0 9185.6 6053.8 9665.6 11037.0 7596.3 15575.0 True False 12398.398315547862 13066.79217660954 9924.5571680284 8579.24446634435 8031.622807694102 6887.655999075138 10115.069552023057 11069.115842726293 9115.772258355795 15125.309281290125 0.8197120524923461 0.863902478528029 0.656155651660293 0.5672111761018203 0.5310055257930593 0.45537290319048934 0.6687512541998271 0.7318274051042838 0.6026833626226689 1.0 13.884677022367859 -9.849202222057482 8.308514646379797 0.9999939674273678 0.6518850587233002 0.42843472718792164 0.11942785834329953 0.0 0.0 0.1304953987134171 0.0316497830913241 1.415134692409603e-10 9.849202222057482 -0.34810890870406763 EDKS(ph)PETGTAGGSSTASYSAGR ddPTM_A459_Selumetinib_30min_R1 1 EDKSPETGTAGGSSTASYSAGR 22 1 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 EDKS(0.994)PET(0.005)GT(0.001)AGGSSTASYSAGR 97.085 0.00010383 12052000.0 4686.5 6127.2 5024.4 5151.5 4920.2 4564.5 5404.8 4370.6 2699.8 4851.2 True False 4795.686331658423 5409.824575541997 4342.114077053652 4251.887230631465 4475.1687787318615 4518.585274234403 4997.111584570558 4254.677490290396 4581.363414409717 5473.898774689587 0.876100660434733 0.9882945955369399 0.7932397466191515 0.776756641955364 0.8175468642979498 0.8254784131426768 0.9128980622872284 0.7772663809501428 0.8369470468824144 1.0 12.418353040774598 -12.137702991148416 1.9980613278347374 3.635823124532285 0.8442666375558214 0.3553866144564588 0.062640747643968 2472886.7257451853 126294.08158589252 29563905.41435291 0.016748496927286454 7.282776947551786e-13 12.137702991148416 -2.7915564869764635 EDKS(ph)PETGTAGGSSTASYSAGR ddPTM_A459_Selumetinib_30min_R2 2 EDKSPETGTAGGSSTASYSAGR 22 1 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 EDKS(0.7)PET(0.275)GT(0.025)AGGSSTASYSAGR;EDKS(0.826)PET(0.15)GT(0.025)AGGSSTASYSAGR 107.09 3.2829e-05 28623000.0 35372.0 32108.0 35887.0 33067.0 30138.0 27065.3 39896.0 46911.0 26022.5 32363.0 True False 33406.165845335076 34570.580356507846 33578.069490811264 28563.217556243326 26351.7950028615 30793.29940066871 41751.243052424215 47047.50324346588 31227.72712940031 31428.596100827788 1.0629226242929508 1.0999721478363236 1.0683922814460955 0.9088289360621808 0.8384655464189643 0.9797860299543465 1.3284475997107787 1.4969648371352708 0.9936087195628128 1.0 14.939790208682304 -7.251216149641821 24.433717279910866 1.246169023789969 0.990489148389432 0.2893158912179671 0.1572419694548067 560.289267234867 1339104.1648329843 0.06147969244779826 0.04705284931545763 5.6076881028014237e-08 7.251216149641821 -0.25567987540053694 EDKS(ph)PSEESAPTTSPESVSGSVPSSGSSGR ddPTM_A459_Selumetinib_30min_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 A0A494C0B4;P54725-2;P54725-3;P54725 A0A494C0B4 RAD23A UV excision repair protein RAD23 homolog A 1 EDKS(0.61)PS(0.064)EES(0.326)APTTSPESVSGSVPSSGSSGR 100.33 2.5021e-08 95803000.0 1167.7 1462.0 914.83 1028.7 1050.8 1261.0 1486.4 1497.4 790.76 1453.5 True False 1194.9051380513258 1290.8283603346392 790.6011108014878 849.0568560905732 955.7553255338075 1248.3154848963923 1374.2796512924954 1457.6840877593097 1341.8619651746903 1640.0708832889416 0.7285692040670244 0.787056445844619 0.48205301298687997 0.5176952196041087 0.5827524500753094 0.7611350811820179 0.8379391801265091 0.8887933458315658 0.8181731526650645 1.0 10.679542453627105 -7.048951807693838 2.3822860066085108 0.8810023695876634 0.6161408865131589 0.6317654478314985 0.09573883160941889 0.22358205629335873 2.518304936549125 0.044959481449621 0.0344756946199073 8.934046165609918e-08 7.048951807693838 -0.2648614830745045 EDKS(ph)PSEESAPTTSPESVSGSVPSSGSSGR ddPTM_A459_Selumetinib_30min_R2 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 A0A494C0B4;P54725-2;P54725-3;P54725 A0A494C0B4 RAD23A UV excision repair protein RAD23 homolog A 1 EDKS(0.654)PS(0.243)EES(0.103)APTTSPESVSGSVPSSGSSGR 110.42 2.3686999999999998e-11 8231200.0 15595.0 13691.0 13688.0 12412.0 16235.0 10285.0 13486.0 13390.0 12866.0 13804.0 True False 14728.292331731333 14741.05567649648 12807.328982367559 10721.464188105729 14195.4141572585 11701.665392065766 14113.125722002029 13428.96268316617 15439.559506076073 13405.442652900738 1.0986800445969869 1.0996321462989316 0.9553827735480442 0.7997844208289357 1.0589291621927026 0.8729040655389101 1.0527907274250403 1.0017545135117447 1.151738133968682 1.0 13.710531238004648 -8.076753178942742 9.133950876683619 1.0767279186047896 0.9876463981097163 0.10470277691705954 0.0975747673537254 0.9768480115269114 109.75117466489452 0.06768150183033701 0.0255276112138174 8.380054074861315e-09 8.076753178942742 -0.08908152049507323 EDKSPSEESAPTT(ph)SPESVSGSVPSSGSSGR ddPTM_A459_Selumetinib_30min_R1 2 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 A0A494C0B4;P54725-2;P54725-3;P54725 A0A494C0B4 RAD23A UV excision repair protein RAD23 homolog A 1 EDKSPSEESAPTT(0.61)S(0.386)PES(0.003)VSGSVPSSGSSGR;EDKSPSEESAPTT(0.864)S(0.135)PESVSGSVPSSGSSGR 172.45 8.537399999999997e-28 52711000.0 4986.3 5707.9 4227.6 3898.2 4857.7 4659.1 5840.9 5523.799999999999 2937.4 5202.7 True False 5102.471088349173 5039.616414469281 3653.5151405445486 3217.4525482767303 4418.321892696593 4612.233684124332 5400.316210464429 5377.29088016888 4984.553260792318 5870.51722358953 0.8691689154485208 0.8584620779611317 0.6223497864657666 0.5480696888764799 0.7526290656200492 0.785660531850749 0.9199046701991284 0.9159824723043626 0.8490824693883635 1.0 12.519271902654106 -7.093347998897445 2.521756296873379 0.9161071512369816 0.7217249733071514 0.4663239465567711 0.09648734839672486 0.3039412989323305 3.787619941024896 0.04634846626438474 0.03474527986724169 8.06588454265681e-08 7.093347998897445 -0.19438217792983026 EDKSPSEESAPTTS(ph)PESVSGSVPSSGSSGR ddPTM_A459_Selumetinib_30min_R2 2 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 A0A494C0B4;P54725-2;P54725-3;P54725 A0A494C0B4 RAD23A UV excision repair protein RAD23 homolog A 1 EDKSPSEESAPT(0.003)T(0.22)S(0.765)PES(0.011)VS(0.001)GSVPSSGSSGR;EDKSPSEESAPT(0.003)T(0.363)S(0.632)PES(0.002)VSGSVPSSGSSGR 124.41 3.8899e-17 50058000.0 95952.0 80316.0 96440.0 104103.0 102909.0 81172.0 84281.0 102927.0 82635.0 91841.0 True False 90619.37196628944 86475.9789433561 90235.15539593274 89923.99181230823 89980.6514018673 92352.70619394864 88200.23349963322 103226.50052951778 99164.30901481377 89189.31169842494 1.0160339870398367 0.9695778260488946 1.0117261101985415 1.0082373111743195 1.0088725844876807 1.0354683138067045 0.9889103505794946 1.1573864464674497 1.1118407253788123 1.0 16.44458320983413 -7.7460704682915456 24.998846722728175 1.1009601991018392 1.0057831264761266 0.47357498512459095 0.04015964888735053 164.74372743898215 267970.79808820324 0.01799398851244888 0.010339673206786602 1.7944424383471166e-08 7.7460704682915456 -0.09517707262571262 EDLAYMNHIMVSVS(ph)PPEEHAMPIGR ddPTM_A459_Selumetinib_30min_R1 1 EDLAYMNHIMVSVSPPEEHAMPIGR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 1 EDLAYMNHIMVS(0.268)VS(0.732)PPEEHAMPIGR 67.13600000000001 0.0009659 3026800.0 670.08 588.29 693.41 816.27 857.96 707.47 605.96 733.39 385.2 632.99 True False 685.6915602512911 519.4127333113986 599.2487306284876 673.723767785605 780.3576694851406 700.3534941313648 560.2519493388052 713.9381148135442 653.6562661051275 714.2404323447322 0.9600290451217948 0.7272239287913921 0.8390014111372188 0.9432730734297444 1.0925700004455874 0.980557053921214 0.7844024560463365 0.9995767286231675 0.9151767899211237 1.0 9.480265995348331 -5.771890648524293 5.239636316660799 0.9592382166132197 0.8293392881957148 0.2598774839885767 0.0903452088980047 0.22697019470462623 17.955241112643215 0.025902198268728447 0.04171872632547394 1.6908666231779175e-06 5.771890648524293 -0.12989892841750494 EDLES(ph)SGLQR ddPTM_A459_Selumetinib_30min_R2 2 EDLESSGLQR 10 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 EDLES(0.649)S(0.351)GLQR;EDLES(0.5)S(0.5)GLQR 185.99 0.00019075 72495000.0 437530.0 235330.0 352100.0 386780.0 414660.0 365800.0 370940.0 458370.0 305750.0 284957.0 True False 413213.83417136257 253379.05429478575 329446.2693374943 334099.89676728507 362566.70369256637 416185.6295982172 388189.4450036653 459703.7808127619 366908.5433687828 276729.55100279825 1.4932045843097697 0.9156197933202429 1.190499056366275 1.207315574200844 1.3101842661136691 1.5039435726689296 1.4027755387777143 1.6612023513459662 1.3258740963485778 1.0 18.078117187082867 -6.41278472962875 2.7798325736899594 1.421293684744488 1.1777354697716693 0.11956894074591162 0.20536877310927423 0.41124763956208205 6.161751311433116 0.06571698242320362 0.07497553522250452 3.865585382713531e-07 6.41278472962875 -0.2435582149728186 EDLESS(ph)GLQR ddPTM_A459_Selumetinib_30min_R1 1 EDLESSGLQR 10 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 EDLES(0.043)S(0.957)GLQR 163.46 0.00039167 10976000.0 3131.8 4286.9 3167.5 3168.4 3275.9 3298.3 3848.5 3828.8 2483.9 3507.6 True False 3204.76484657801 3784.9877550742585 2737.370897832068 2615.0984182340558 2979.5954234071214 3265.1220966167884 3558.204546554874 3727.2477863048252 4214.996883121821 3957.834626917297 0.8097268200096973 0.9563279196489151 0.6916334702857881 0.66073968842678 0.7528347453283786 0.8249768887286599 0.8990281004556046 0.9417391421449883 1.0649754930273134 1.0 11.950495617130715 -7.584935077678147 1.4407330150057116 1.0249839889637067 0.7754691400169811 0.6303545708763715 0.07747654863915718 0.31036406610349865 1.2259441714022727 0.06274052551485935 0.02804800895325188 2.6005482879158854e-08 7.584935077678147 -0.2495148489467256 EDLNCQEEEDPMNK ddPTM_A459_Selumetinib_30min_R1 1 EDLNCQEEEDPMNK 14 0 K7ENA8;O75821;K7EL20 K7ENA8 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 136.48 0.028557 0.0 2054.1 2794.2 1834.0 2351.8 1796.8 1921.7 2368.3 2230.9 1053.3 1832.4 False True 2101.95653341717 2467.053765011661 1584.952873440888 1941.1022787535833 1634.2797572508043 1902.3694427639953 2189.6572242707302 2171.7292850155236 1787.373170011763 2067.606389087485 1.016613483354946 1.1931931425789741 0.7665641206208448 0.9388161542730903 0.7904211197432388 0.9200829774972716 1.0590300145266582 1.0503591478908092 0.8644649094940166 1.0 11.013745850121515 -5.246809014691337 24.985944794109148 0.9259973068879362 1.1049033060266282 0.3397022581743664 0.10100275522084536 941.0372175936578 1607110.6422564106 0.026556216653189982 0.0696154036505073 5.664883531455605e-06 5.246809014691337 0.17890599913869198 EDLNCQEEEDPMNK ddPTM_A459_Selumetinib_30min_R2 1 EDLNCQEEEDPMNK 14 0 K7ENA8;O75821;K7EL20 K7ENA8 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 160.22 0.00021351 0.0 24130.0 22302.0 20424.0 18997.0 19412.0 16283.0 19629.0 17242.0 14743.0 18567.0 False True 22788.951200043408 24012.49168776748 19109.942075969833 16409.575828347115 16973.291014518138 18525.835447642876 20541.787394125604 17292.17136543325 17692.01195383798 18030.92246714053 1.2638816034827882 1.3317395009338946 1.0598427291113752 0.9100796622164977 0.9413434640102404 1.0274480122358838 1.139253270683231 0.9590286574048787 0.9812039282005577 1.0 14.13818558689793 -5.350583127134768 4.315056164156308 0.997092887364691 1.2980128379763562 0.7943844989014264 0.06071659813832826 0.09508592374587677 3.1185835057230062 0.01745195453570299 0.039169543126774876 4.460842326297657e-06 5.350583127134768 0.3009199506116652 EDLPAENGETKTEES(ph)PASDEAGEK ddPTM_A459_Selumetinib_30min_R1 2 EDLPAENGETKTEESPASDEAGEK 24 1 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 EDLPAENGET(0.035)KT(0.025)EES(0.551)PAS(0.389)DEAGEK;EDLPAENGET(0.001)KT(0.119)EES(0.873)PAS(0.007)DEAGEK 108.08 2.6975e-07 23573000.0 2893.4 4843.3 2352.99 2684.8999999999996 2663.3 3402.5 3313.6 3317.6000000000004 2241.41 3655.6000000000004 True False 2960.810590423661 4276.244184410917 2033.4668820488976 2216.032616814991 2422.4049852438043 3368.273939222821 3063.652484205333 3229.606470916449 3803.5090638906886 4124.83186855938 0.7178015213157621 1.0367075121305291 0.49298176188672066 0.5372419258361074 0.5872736301588559 0.8165845412746989 0.7427339057277333 0.782966815092128 0.9221003873835674 1.0 12.010119599817134 -8.195975467133467 1.0530957150691966 1.00226139563771 0.6913034457359685 0.3419371755730829 0.1444031537830956 0.6218504224388827 1.3675019472769276 0.1457041569792448 0.050092661456321186 6.368314938742559e-09 8.195975467133467 -0.3109579499017415 EDLPAENGETKTEES(ph)PASDEAGEK ddPTM_A459_Selumetinib_30min_R2 3 EDLPAENGETKTEESPASDEAGEK 24 1 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 EDLPAENGET(0.012)KT(0.01)EES(0.694)PAS(0.284)DEAGEK;EDLPAENGET(0.014)KT(0.015)EES(0.943)PAS(0.029)DEAGEK;EDLPAENGET(0.008)KT(0.022)EES(0.633)PAS(0.337)DEAGEK 91.774 2.2016e-05 58031000.0 150821.0 99111.0 109272.0 95550.0 90766.0 87275.0 120922.0 110180.0 78715.0 92739.0 True False 142438.97260429955 106712.49500790628 102241.55848635807 82535.92516705606 79363.16362166451 99296.33904643064 126545.11260239733 110500.60555871918 94460.19948086247 90061.38410514062 1.5815765438160667 1.184886242513513 1.1352430289878503 0.9164407807757086 0.881211902417726 1.1025406730426088 1.4050984654495695 1.22694767193137 1.048842413642972 1.0 16.4586210294064 -4.712213631238466 2.4577710547926954 1.0966396097575288 1.7490854532089914 0.5142815480327854 0.1429042948849535 0.6730520399336731 4.287973255885291 0.04229197191756953 1.0065422029277737 1.9399313826413182e-05 4.712213631238466 0.6524458434514626 EDLPAENGETKTEESPAS(ph)DEAGEKEAK ddPTM_A459_Selumetinib_30min_R1 1 EDLPAENGETKTEESPASDEAGEKEAK 27 2 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 EDLPAENGET(0.001)KT(0.001)EES(0.004)PAS(0.994)DEAGEKEAK 53.99800000000001 0.0042324 30458000.0 4293.4 4906.5 5318.4 5782.8 4307.2 4335.1 4531.7 4134.5 2423.6 4188.1 True False 4393.427866497868 4332.044699030033 4596.190491880053 4772.942536600143 3917.614520497924 4291.492829955868 4189.8702205074005 4024.839629251279 4112.672187259572 4725.683430548618 0.929691531619972 0.9167022638516253 0.9725980505102239 1.01000048072328 0.82900485783135 0.908121098889956 0.8866167787335231 0.85169472064785 0.8702809334780429 1.0 12.206307272316065 -6.261135933546028 24.999802118216817 0.8841793895845537 0.9554483762902106 0.3019301930607192 0.04870414162405917 32.339408003862054 2664305.066909808 0.014348892978786523 0.017403169015693207 5.481053818761726e-07 6.261135933546028 0.07126898670565696 EDLQELNDR ddPTM_A459_Selumetinib_30min_R1 1 EDLQELNDR 9 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 162.64 0.013081 7583100.0 3154.2 3845.4 2296.1 2569.1 2671.0 2697.9 3234.0 2821.1 1613.7 2683.6 False True 3227.686722995199 3395.178780322039 1984.3022315744952 2120.4549129797715 2429.4085216033523 2670.7615754972076 2990.0567762916626 2746.275263775738 2738.331040015171 3028.0662004776086 1.0659234340669648 1.1212366426422669 0.6553034511800028 0.7002670260793235 0.802297030765103 0.8820023733549668 0.9874476244343829 0.9069402985121578 0.9043167681021179 1.0 11.564181030955593 -7.058272295262804 7.788273431959136 0.9412304847826479 0.8598412601911708 0.06980261713471003 0.13767357473703198 1.0414127365794006 126.33683499133747 0.058981241905118165 0.04588446776844655 8.74435347209187e-08 7.058272295262804 -0.08138922459147713 EDLRLPEGDLGK ddPTM_A459_Selumetinib_30min_R1 2 EDLRLPEGDLGK 12 1 P63241;P63241-2;I3L397;I3L504 P63241 EIF5A Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A 0 ; 129.34 0.006545399999999999 118729000.0 21535.4 23737.6 20124.5 21773.1 20868.7 18853.4 21473.4 19941.5 12343.400000000001 17027.0 False True 22037.132919406133 20958.390756689147 17391.70343596573 17970.8368167062 18981.12976966824 18663.751913517575 19853.64414966648 19412.586640879043 20945.84827373321 19212.581307024986 1.1470157272072734 1.0908680318258857 0.9052247148906815 0.9353681595161423 0.9879531264613508 0.9714338544760389 1.0333668252275447 1.0104101229635878 1.0902152052870928 1.0 14.229763744917339 -10.52129174786346 14.968491349426591 0.9999948165883235 1.013240945262589 0.0003913100686052662 0.0709779836206422 0.0 0.0 0.07356899376496065 0.017843101886078818 3.010982643933125e-11 10.52129174786346 0.013246128674265556 EDLRLPEGDLGK ddPTM_A459_Selumetinib_30min_R2 1 EDLRLPEGDLGK 12 1 P63241;P63241-2;I3L397;I3L504 P63241 EIF5A Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A 0 99.732 0.039724 17591000.0 72488.0 69371.0 70687.0 74538.0 77975.0 59527.0 60173.0 67438.0 52951.0 69009.0 False True 68459.4071524553 74691.53263707802 66139.07537818646 64385.79581477797 68179.08339465548 67726.30391769558 62971.163730537475 67634.23341503808 63542.679574555696 67016.53086308498 1.0215301548854883 1.114524008854966 0.9869068799354721 0.9607449831492829 1.0173472502470413 1.0105910145671473 0.9396362795798517 1.0092171669287846 0.9481642627007003 1.0 16.03222938635203 -5.288629831679374 21.510409026141875 0.9841199486467274 1.0680269833428717 0.5099474164426119 0.03291885546519006 83.21275038576128 65829.72494086303 0.00814005871192201 0.01696090442824005 5.1448198041082615e-06 5.288629831679374 0.08390703469614436 EDLS(ph)PAFDHSPNK ddPTM_A459_Selumetinib_30min_R1 1 EDLSPAFDHSPNK 13 0 K7EIY0;K7ENP9;K7EIE9;D3DUJ3;K7EQG9;P17706-2;P17706-4;P17706;P17706-3 K7EIY0 PTPN2 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 2 1 EDLS(0.725)PAFDHS(0.275)PNK 159.58 0.00036425 15519000.0 6355.8 8139.6 5077.1 5025.3 5312.4 5868.8 6456.6 5687.0 3757.1 6113.1 True False 6503.877773766055 7186.611848002618 4387.657706514032 4147.725691564072 4831.894357980396 5809.7652004440515 5969.57346376152 5536.162286020569 6375.524292273041 6897.7759316364845 0.9428949038393919 1.0418737748556595 0.6360974537299979 0.6013134860673898 0.7005003360313616 0.8422664432745202 0.8654345288866536 0.8026010616884629 0.9242869521220386 1.0 12.751915549505032 -8.42480236402912 1.0571628052413926 1.0011650992243333 0.7905969905944193 0.20641594059936408 0.1272116473595462 0.930281762057435 2.265507071998642 0.1359110903609033 0.044874579253782854 3.760084769065753e-09 8.42480236402912 -0.21056810862991393 EDLSPAFDHS(ph)PNK ddPTM_A459_Selumetinib_30min_R1 3 EDLSPAFDHSPNK 13 0 K7EIY0;K7ENP9;K7EIE9;D3DUJ3;K7EQG9;P17706-2;P17706-4;P17706;P17706-3 K7EIY0 PTPN2 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 2 1 EDLSPAFDHS(1)PNK;EDLSPAFDHS(1)PNK;EDLSPAFDHS(1)PNK 147.24 0.00038269 66195000.0 26175.8 33477.9 21441.2 21630.2 22448.4 24752.699999999997 25416.199999999997 24392.5 13858.400000000001 24985.5 True False 26785.64521075954 29558.291904546517 18529.602808081127 17852.89161914098 20417.94618358691 24503.710311653394 23499.035571299995 23745.53166199344 23516.69262251117 28192.63230437967 0.950093801868882 1.0484403011901338 0.657249830665957 0.6332467087994323 0.7242298613036933 0.8691529775262168 0.8335169031963527 0.8422601836404122 0.8341432033949486 1.0 14.783030566048788 -9.26036935482414 0.7935883827413591 1.0025944723294515 0.8103846663889872 0.16885472948081748 0.1194396864368833 6.031019652329216 4.886349712157295 0.17278906470988795 0.04559893019633503 5.490737040147431e-10 9.26036935482414 -0.19220980594046433 EDLSPAFDHS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 6 EDLSPAFDHSPNK 13 0 K7EIY0;K7ENP9;K7EIE9;D3DUJ3;K7EQG9;P17706-2;P17706-4;P17706;P17706-3 K7EIY0 PTPN2 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 2 1 EDLSPAFDHS(1)PNK;EDLS(0.009)PAFDHS(0.991)PNK;EDLSPAFDHS(1)PNK;EDLS(0.001)PAFDHS(0.999)PNK;EDLS(0.008)PAFDHS(0.992)PNK;EDLS(0.001)PAFDHS(0.999)PNK 148.33 0.00036342 190439500.0 874422.0 759331.0 814804.0 869394.0 812293.0 748611.0 867664.0 855019.0 712284.0 739426.0 True False 825825.12582861 817569.2460660089 762380.397731519 750981.0374116988 710245.491348444 851725.3700359509 908012.0952435998 857506.9637339844 854760.7028778091 718076.8501205273 1.15005117584559 1.13855396665243 1.0616975016024475 1.0458226543379705 0.9890939823909254 1.186120078781249 1.2645054566112142 1.1941715759114837 1.1903471094136229 1.0 19.453778727057177 -6.801832625990531 24.791730740529022 1.1852570171327088 1.0778739993200974 0.24019465259245842 0.07666098607351504 172.71527313968144 106004.34727814929 0.027011763215940062 0.023822445521436034 1.5782193870548523e-07 6.801832625990531 -0.10738301781261139 EDLVGPEVGAS(ph)PQSGR ddPTM_A459_Selumetinib_30min_R1 2 EDLVGPEVGASPQSGR 16 0 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 EDLVGPEVGAS(0.99)PQS(0.01)GR;EDLVGPEVGAS(0.98)PQS(0.02)GR 118.05 0.0017935 29097000.0 6130.2 7973.299999999999 4629.7 6019.5 6276.3 6298.1 6228.3 5831.2 3220.0 5699.1 True False 6273.021732707232 7039.782329313394 4001.012169121747 4968.307325009432 5708.609773170761 6234.746832217263 5758.494316566899 5676.537633592951 5464.104820504961 6430.634998934992 0.975490248435207 1.0947258444118328 0.6221799510910467 0.7725998017042263 0.8877210064194581 0.9695382856047386 0.8954783341801534 0.8827336078836802 0.8496991076946363 1.0 12.650745489490884 -6.5214930225492385 24.41878994906786 0.912656623304485 0.8607633849746439 0.038833685629933834 0.12190737310112731 176.5792124791535 3111736.550754188 0.04304193257948686 0.043633265987397286 3.0095875210418975e-07 6.5214930225492385 -0.05189323832984116 EDLVGPEVGAS(ph)PQSGR ddPTM_A459_Selumetinib_30min_R2 2 EDLVGPEVGASPQSGR 16 0 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 EDLVGPEVGAS(0.948)PQS(0.052)GR;EDLVGPEVGAS(0.918)PQS(0.082)GR 119.48 0.0016802 35661000.0 142814.0 88862.0 131996.0 140052.0 145566.0 94846.0 132752.0 127957.0 110463.0 105216.0 True False 134876.9696097388 95677.42966363506 123503.52106637863 120976.6759968243 127278.69770344876 107910.17557373561 138925.23104309777 128329.33368557821 132558.6865940991 102178.14069600136 1.320017850109667 0.9363786521453048 1.2087078530213637 1.1839780521819439 1.2456548615630632 1.0560984457016898 1.359637492880456 1.2559372563587885 1.297329210447129 1.0 16.640727063250814 -5.4633716036840685 24.999933753550962 1.211767038465289 1.114284473957112 0.038970819538791335 0.13270752428830268 618.7735113626591 259954.76341993234 0.0327701593424758 0.06821632862249256 3.4405541407325173e-06 5.4633716036840685 -0.09748256450817694 EDLVGPEVGAS(ph)PQSGRK ddPTM_A459_Selumetinib_30min_R1 2 EDLVGPEVGASPQSGRK 17 1 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 EDLVGPEVGAS(0.749)PQS(0.251)GRK;EDLVGPEVGAS(0.725)PQS(0.275)GRK 85.969 0.0058702 29990000.0 5809.8 5921.4 6307.5 6215.7 6627.700000000001 4969.9 5318.6 5975.4 3305.8 4812.700000000001 True False 5945.157036097112 5228.119735215821 5450.976144617453 5130.244678139571 6028.225705215471 4919.907318308153 4917.4137199705765 5816.912981165339 5609.701153920901 5430.456924667834 1.0947802585619 0.9627403011829636 1.0037785439115465 0.9447169454259826 1.1100770688065444 0.9059840426980442 0.9055248551246654 1.071164556106141 1.0330072094741882 1.0 12.406857877759593 EDLVGPEVGAS(ph)PQSGRK ddPTM_A459_Selumetinib_30min_R2 2 EDLVGPEVGASPQSGRK 17 1 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 EDLVGPEVGAS(0.979)PQS(0.021)GRK;EDLVGPEVGAS(0.5)PQS(0.5)GRK 117.37 0.0008141 36112000.0 159434.0 140067.0 153363.0 165706.0 140607.0 111275.0 116759.0 109168.0 81638.0 124024.0 True False 150573.29654487016 150809.6885136095 143495.79154900918 143136.55694120572 122942.69161747112 126602.12119612226 122188.52485356927 109485.66080626471 97967.88115630657 120443.10486694907 1.2501612002713254 1.252123886047323 1.191398973876719 1.1884163655472484 1.0207532573432352 1.0511363131660956 1.0144916555293748 0.909023899103325 0.8133955137118858 1.0 16.877992278897437 -6.498572487488901 0.6950852509204515 0.9025911457587426 1.2697812684184056 0.8481411925334323 0.05468186982890963 0.2740910746050536 0.2942824178730369 0.037730316088103004 0.05170154391474857 3.1726890705134554e-07 6.498572487488901 0.367190122659663 EDMAALEKDYEEVGADSADGEDEGEEY ddPTM_A459_Selumetinib_30min_R1 1 EDMAALEKDYEEVGADSADGEDEGEEY 27 1 Q9BQE3;F5H5D3 Q9BQE3 TUBA1C Tubulin alpha-1C chain 0 140.73 6.077000000000001e-12 5494000.0 2627.9 2652.0 4669.5 4719.0 3335.5 3333.9 2349.1 1991.1 1400.5 1399.1 False True 2689.1249569967295 2341.5026071186485 4035.407547727499 3894.915236600969 3033.804613930356 3300.3639929390024 2171.9054957287385 1938.289559995701 2376.5462115270784 1578.6881133880704 1.7033921609921525 1.4831951841921953 2.5561778248060594 2.4671847488874628 1.92172512619951 2.0905737903201103 1.3757660409994132 1.227784983973737 1.5053931117696837 1.0 10.624510464275472 -7.303441710987148 4.628695255560872 1.2827068143219695 2.0516139779620617 0.5750820653561073 0.3203635765122151 0.174644385499648 8.785238920444838 0.1488692669927448 0.10086372805313491 4.972311053246379e-08 7.303441710987148 0.7689071636400922 EDNLLFQNNLNK ddPTM_A459_Selumetinib_30min_R1 2 EDNLLFQNNLNK 12 0 Q86VD1-2;Q86VD1 Q86VD1-2 MORC1 MORC family CW-type zinc finger protein 1 0 ; 97.452 0.009131 11556300.0 9723.599999999999 12952.4 13137.8 11346.2 4771.2 9849.3 6869.799999999999 9258.9 10210.2 13856.5 False True 9950.140961168003 11435.926986592605 11353.758920769746 9364.799164552214 4339.645802423775 9750.22498444888 6351.60545509229 9013.323894854202 17325.96367649681 15635.116748739758 0.6363969723456026 0.7314257495080347 0.7261703959892014 0.5989593371796886 0.27755762058978967 0.623610628634083 0.4062397203144806 0.5764794749985289 1.108144183054683 1.0 13.93250237157857 -8.257008661554249 24.716596326984188 1.0540721284715207 0.5698160893510208 0.6776168081524542 0.13296795926720267 180.18823239110588 1005190.5423710078 0.10483072226092695 0.03652680718527617 5.533390733301912e-09 8.257008661554249 -0.48425603912049986 EDNPEEPSKEITSHEEGGGDVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 EDNPEEPSKEITSHEEGGGDVSPR 24 1 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 EDNPEEPSKEITSHEEGGGDVS(1)PR;EDNPEEPS(0.003)KEITS(0.001)HEEGGGDVS(0.996)PR 108.19 2.6653000000000004e-07 18487700.0 1957.77 2517.01 3273.33 3527.44 2981.5499999999997 2625.15 2586.99 2347.63 1286.92 1972.26 True False 2003.3822318427206 2222.3172990737976 2828.8297651146486 2911.4388222495677 2711.8693289354055 2598.743374445493 2391.8512615024015 2285.363226223047 2183.8092470820625 2225.4187824392498 0.900227070810844 0.9986063372027207 1.2711449132347166 1.3082655926262927 1.2185883171000131 1.1677547592175201 1.0747870380067195 1.0269362531928006 0.9813026043971914 1.0 11.119861134672568 -7.588748814907261 2.3054593213091383 0.9976327594662135 1.153663779768101 0.23292691104099028 0.11462885967338504 0.5035709985444544 5.3555724287178785 0.07653912034794963 0.03839707262658849 2.5778116678764927e-08 7.588748814907261 0.15603102030188754 EDNPEEPSKEITSHEEGGGDVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 EDNPEEPSKEITSHEEGGGDVSPR 24 1 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 EDNPEEPSKEITS(0.001)HEEGGGDVS(0.999)PR;EDNPEEPSKEIT(0.001)S(0.003)HEEGGGDVS(0.996)PR 57.222 0.005447 17288400.0 66066.0 56559.0 70435.0 71291.0 66039.0 50332.0 49962.0 50629.0 45766.0 69711.0 True False 62394.316203152404 60896.89343415125 65903.28878382956 61581.04281616543 57742.5904238494 57264.776131595 52285.33199782483 50776.32200791785 54920.478808882144 67698.26229906992 0.9216531426983114 0.8995340702413848 0.9734856781506337 0.9096399335055232 0.8529405107735343 0.8458825114094802 0.7723290114426343 0.7500387791876225 0.8112538925483864 1.0 16.046831182261258 -6.4153152389793 1.9487979914879479 0.8154170290388109 0.9300142726762947 0.277804454782415 0.06628597920011754 0.3612709601523251 2.7191414222762527 0.02317192041041434 0.027092950253141568 3.8431272178736604e-07 6.4153152389793 0.1145972436374838 EDPQARPLEGSSSEDSPPEGQAPPS(ph)HSPR ddPTM_A459_Selumetinib_30min_R1 2 EDPQARPLEGSSSEDSPPEGQAPPSHSPR 29 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EDPQARPLEGSSSEDSPPEGQAPPS(0.562)HS(0.438)PR;EDPQARPLEGS(0.011)S(0.011)S(0.011)EDS(0.003)PPEGQAPPS(0.536)HS(0.429)PR 69.523 0.0002076 28798100.0 2877.5 3156.7 3665.9 4069.0 3569.7 3002.0 3011.4 2657.7 1889.11 2473.9 True False 2944.5401513596753 2787.112096489984 3168.0909153473035 3358.4255345898155 3246.821265281724 2971.802605597916 2784.2476735079495 2587.209162573739 3205.6816948646338 2791.449162826634 1.0548428359619562 0.9984463029474417 1.134926961069669 1.2031118385795923 1.163131074898021 1.0646092521307662 0.9974201610351404 0.9268337023748335 1.148393364118638 1.0 11.44679856701862 -7.019694554519876 5.2327238562019165 1.0137492873583547 1.1116246164171641 0.26107098495825176 0.07333911473732123 0.26705652911656674 21.587858883938175 0.029641954901609004 0.024030681130480305 9.556644821262623e-08 7.019694554519876 0.09787532905880947 EDPQARPLEGSSSEDSPPEGQAPPS(ph)HSPR ddPTM_A459_Selumetinib_30min_R2 1 EDPQARPLEGSSSEDSPPEGQAPPSHSPR 29 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EDPQARPLEGSSSEDSPPEGQAPPS(0.641)HS(0.359)PR 120.34 7.591900000000002e-14 11180000.0 17092.0 21909.0 22027.0 26155.0 31757.0 14602.0 12005.0 14308.0 7499.9 24185.0 True False 16142.09506469714 23589.349851461644 20609.806801184255 22592.6438801084 27767.401748817865 16613.292956241552 12563.256287456208 14349.633911183084 9000.08956471474 23486.716209823542 0.6872861629735005 1.0043698591459616 0.8775090828816677 0.9619328508196822 1.182259857050765 0.7073484776595923 0.5349090173023637 0.6109680801261274 0.38319914475529654 1.0 14.519557396902357 -6.973312806813585 13.279139549685716 0.6028795619854705 0.9437258710414326 0.3907785759077965 0.1848521997389924 1.2150222980084349 602.8356819584853 0.06239798511903738 0.054951770049852466 1.063376829954021e-07 6.973312806813585 0.340846309055962 EDPQARPLEGSSSEDSPPEGQAPPSHS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 EDPQARPLEGSSSEDSPPEGQAPPSHSPR 29 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EDPQARPLEGSSSEDSPPEGQAPPS(0.228)HS(0.772)PR 120.66 7.557100000000001e-14 12621000.0 1136.0 1177.8 1543.2 1594.8 1220.2 963.48 1095.7 1339.3 684.72 1031.2 True False 1162.466589728788 1039.9026284556355 1333.6419161908289 1316.298118103671 1109.8331254438074 953.7882659698463 1013.0504668468689 1303.7774133404855 1161.9198300298617 1163.5645647386013 0.9990563695018849 0.893721465889822 1.1461692428648649 1.131263496666712 0.9538216950540558 0.819712369106151 0.8706439655752614 1.1205028520556428 0.9985864688917292 1.0 10.184335550965157 -2.348285525348161 13.712726616580944 0.9926741351119699 1.346852914397564 0.0 0.10739905709093978 0.0 0.0 0.02668884947915927 0.0 0.004484504608480179 2.348285525348161 0.35417877928559416 EDPQARPLEGSSSEDSPPEGQAPPSHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 EDPQARPLEGSSSEDSPPEGQAPPSHSPR 29 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EDPQARPLEGSSSEDSPPEGQAPPS(0.138)HS(0.862)PR 104.88 1.0144e-10 9705500.0 7629.2 10350.0 9384.6 14097.0 12096.0 6411.9 5295.5 5831.7 4390.0 11180.0 True False 7205.199606107385 11143.811719504676 8780.805053179909 12176.964281318606 10576.392340387973 7295.081023566993 5541.751242834183 5848.669281510095 5268.122666848587 10857.204350871503 0.6636330470770799 1.026397897596002 0.8087537794639628 1.121556147217692 0.9741358823681908 0.6719115517966114 0.5104215656021386 0.5386901722118388 0.4852190763477448 1.0 13.406365047299685 -6.859303804735463 4.640900487134426 0.5952724657404839 0.9295694033099742 0.3671653682821585 0.1791770225493414 0.19725479584937397 7.306839408319309 0.06170339543020255 0.05459981670618976 1.3825988625742645e-07 6.859303804735463 0.3342969375694903 EDQEAAELLS(ph)EPEEESER ddPTM_A459_Selumetinib_30min_R1 2 EDQEAAELLSEPEEESER 18 0 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 EDQEAAELLS(0.989)EPEEES(0.011)ER;EDQEAAELLS(0.972)EPEEES(0.028)ER 274.16 2.0853999999999998e-54 31441000.0 3423.8999999999996 5516.0 3174.7 2852.8 4127.6 4415.4 5046.3 5370.200000000001 2131.13 4204.6 True False 3503.6702082503507 4870.184155681173 2743.5931773788384 2354.6120336883323 3754.2593087869673 4370.985084862435 4665.653528200563 5227.764851131998 3616.371958423212 4744.301366272233 0.7385007691877106 1.0265334724104702 0.5782923481386212 0.49630321767237034 0.7913197368692501 0.921312696519714 0.9834226723810621 1.1019040418251589 0.762255952822138 1.0 12.211979939954345 -6.7290443900933266 3.4242869821226156 0.9664094081585731 0.7159369162983552 0.3706550111346659 0.15083472420555719 0.27628848918338395 6.72550283023818 0.057045264241403895 0.05425684707258108 1.866188934243952e-07 6.7290443900933266 -0.2504724918602179 EDQEAAELLS(ph)EPEEESER ddPTM_A459_Selumetinib_30min_R2 2 EDQEAAELLSEPEEESER 18 0 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 EDQEAAELLS(1)EPEEESER;EDQEAAELLS(1)EPEEESER 238.8 6.115500000000001e-25 57197000.0 159190.0 97739.0 151614.0 193152.0 192925.0 187970.0 228538.0 248214.0 195963.0 140860.0 True False 150342.85708806073 105235.26701958136 141859.32030484162 166844.36439421543 168688.03672861686 213861.16127823052 239165.4698394559 248936.26164596 235161.0756637015 136793.00580176726 1.0990536848494226 0.7693029800959443 1.0370363563062295 1.2196849057911405 1.2331627318217577 1.5633925142937943 1.7483749877244534 1.8198025563288263 1.719101603809216 1.0 17.06163494184583 -6.405543201105276 1.275737612284172 1.6446757702456782 0.9519539482155777 0.5367310217151402 0.2361706798901887 0.2970663664953948 0.9947618632494865 0.0957017275787071 0.119782520336963 3.9305814381005693e-07 6.405543201105276 -0.6927218220301006 EDQFNGS(ph)PPRPQPR ddPTM_A459_Selumetinib_30min_R1 1 EDQFNGSPPRPQPR 14 1 Q69YN4-3;Q69YN4;Q69YN4-4;Q69YN4-2 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 EDQFNGS(1)PPRPQPR 112.03 0.021832 0.0 1724.5 2319.5 1504.3 1547.0 1662.0 1489.0 1693.8 1523.2 916.61 1461.3 True False 1764.677494707127 2047.931861693705 1300.0243225284228 1276.8454907865428 1511.6723934499328 1474.0220119038295 1566.0353023137966 1482.7997879490993 1555.4202234543645 1648.8720892673757 1.0702331043102353 1.2420198480063054 0.7884324872683408 0.7743751010752258 0.9167917895448134 0.8939577675541616 0.9497615445777937 0.8992812708764659 0.9433237626973638 1.0 10.68726377116511 -5.259331448641618 24.999985378206553 0.8904263788252058 1.1561264856820306 0.652170099067656 0.07598500699881212 105.61202229201994 1252533.4908893686 0.01990398964401337 0.04755240661900895 5.503874865650251e-06 5.259331448641618 0.26570010685682477 EDQS(ph)VSSSQSK ddPTM_A459_Selumetinib_30min_R2 1 EDQSVSSSQSK 11 0 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 1 EDQS(0.537)VS(0.154)S(0.154)S(0.154)QSK 80.455 0.043753 4909600.0 6869.0 8027.1 8384.3 8550.8 8424.2 4734.3 6663.4 5390.0 5888.1 7890.1 True False 6487.248478785669 8642.75275880541 7844.863266135616 7386.166289047249 7365.876682696465 5386.406851303551 6973.261303276608 5405.684007637463 7065.884527259952 7662.292312058257 0.8466459141184937 1.1279591546258538 1.0238271977421227 0.9639630006575884 0.961315019410664 0.7029759022410156 0.9100750818789161 0.7054917493986052 0.9221632690964126 1.0 12.90356034946233 -6.552562930804643 18.357695929992964 0.8334405152935287 0.9977659527087994 0.2833162906474681 0.10792956593681137 12.297763678901163 7604.106697918882 0.033501933153206605 0.0335065031686818 2.801799601590506e-07 6.552562930804643 0.16432543741527073 EDQTEYLEER ddPTM_A459_Selumetinib_30min_R1 2 EDQTEYLEER 10 0 P07900;P07900-2;G3V2J8;P08238;Q58FF7;Q58FF6 P07900;P08238;Q58FF6 HSP90AA1;HSP90AB1;HSP90AB3P;HSP90AB4P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4 0 ; 176.95 0.0010443 277030000.0 4060.5 5489.799999999999 3715.3 4163.6 3951.1000000000004 4178.9 4894.2 4473.1 2290.36 4439.1 False True 4155.101749642382 4847.051663861219 3210.78266668208 3436.5054204517473 3593.723702623364 4136.864060137617 4525.026553656976 4354.458857323475 3886.5736387241423 5008.9017254956625 0.8295434762659889 0.9676875150473375 0.6410153048799042 0.6860796255913133 0.7174674009535977 0.8259024207004677 0.9033969523946281 0.8693440390652851 0.7759332986992356 1.0 12.290278590901362 -6.990578947866358 6.123960385611474 0.8750390235800006 0.7677894286732271 0.24403876589577356 0.09764531021555405 0.26910060335188274 40.566233617240826 0.038008400494996694 0.03223035526877208 1.0219297730479498e-07 6.990578947866358 -0.10724959490677355 EDQTEYLEER ddPTM_A459_Selumetinib_30min_R2 2 EDQTEYLEER 10 0 P07900;P07900-2;G3V2J8;P08238;Q58FF7;Q58FF6 P07900;P08238;Q58FF6 HSP90AA1;HSP90AB1;HSP90AB3P;HSP90AB4P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4 0 ; 190.57 0.0024905 607120000.0 141130.0 127174.0 145540.0 162587.0 182651.0 120097.0 126381.0 151577.0 123559.0 139906.0 False True 133286.55958815268 136927.836871139 136176.1148519704 140442.37012178096 159704.74845934229 136639.27161797983 132257.96691920064 152018.0639750769 148274.25252691258 135866.55026055747 0.9810108472802391 1.0078112427860004 1.0022784459517022 1.0336787815135382 1.175453032060277 1.0056873553935128 0.9734402372442924 1.1188777788465587 1.091322715138938 1.0 17.051830789165002 -5.923664658247582 4.9419190013780625 1.0631859903968313 0.9992691656351854 0.19783814722402626 0.05691237866408952 0.3507055329563947 15.634742644166142 0.01690356461225446 0.025440066351241603 1.192162184235163e-06 5.923664658247582 -0.06391682476164584 EDQTEYLEERR ddPTM_A459_Selumetinib_30min_R1 4 EDQTEYLEERR 11 1 P07900;P07900-2;G3V2J8;P08238;Q58FF7 P07900;P08238 HSP90AA1;HSP90AB1;HSP90AB3P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 ;;; 193.62 2.7522e-05 38901800.0 8170.700000000001 6912.299999999999 14916.5 15384.900000000001 12010.7 9071.800000000001 8343.0 8716.0 6110.9 6919.5 False True 8361.061412585397 6103.00470255891 12890.921230469468 12698.216025340582 10924.334305661318 8980.545928535365 7713.680793012163 8484.823366441935 10369.750977522905 7807.685226637664 1.070875831937969 0.7816663358478061 1.6510554480973707 1.6263739708688278 1.3991770913599986 1.1502187483040716 0.9879600123600292 1.0867271310444309 1.3281466499371901 1.0 12.930679175277682 -6.898715698276512 6.088445531858623 1.102840559627226 1.3127813141221922 0.13204877903892331 0.2521644285152747 0.5013233849409009 25.81989533369711 0.0998354129688641 0.0879758128898365 1.2626538338049404e-07 6.898715698276512 0.2099407544949663 EDRPIS(ph)FYQLGSNQLQSNAVSLAR ddPTM_A459_Selumetinib_30min_R2 1 EDRPISFYQLGSNQLQSNAVSLAR 24 1 O43150;O43150-2 O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 1 EDRPIS(0.986)FY(0.014)QLGSNQLQSNAVSLAR 75.127 0.011382 0.0 4414.1 3167.4 3968.3 3965.7 3480.7 4901.6 4490.4 2332.4 3712.8 3736.3 True False 4168.781993042336 3410.3293952037793 3712.983898358356 3425.5648187859233 3043.4233481471915 5576.750907705355 4699.212497558799 2339.1868978503953 4455.463744299646 3628.423310926763 1.1489238260839956 0.9398929239964345 1.0233050502065026 0.9440918341776869 0.8387729565572237 1.5369625949958288 1.2951114285390637 0.6446841223861849 1.2279338331010896 1.0 11.82512706273061 EDRYEEEIK ddPTM_A459_Selumetinib_30min_R2 1 EDRYEEEIK 9 1 P09493-3;P09493-9;A0A0S2Z4G6;P09493-4;P09493-10;P09493;Q6ZN40;P09493-2;H7BYY1;P09493-8;P09493-7;P09493-5;H0YKJ4;F5H7S3;A0A494BZZ2;H0YK48;B7Z596;P09493-6;A0A494C0V8;H0YL42 P09493-3 TPM1 Tropomyosin alpha-1 chain 0 104.42 0.040467 3292200.0 26985.0 26657.0 28427.0 24624.0 40665.0 25578.0 31449.0 33029.0 21814.0 26960.0 False True 25485.28172951393 28701.50618423537 26598.03776897738 21270.16872123069 35556.29915028744 29101.137326033862 32911.44081501128 33125.10892175471 26177.409534085436 26181.594749507665 0.9734044840791514 1.096247438662043 1.0159059455107313 0.8124092105440088 1.3580646820971845 1.1115112583652338 1.2570449252572808 1.2652059295348164 0.9998401466578996 1.0 14.676265355638353 -6.260743848091598 24.99998647854702 1.1804381428609607 0.9861467658068586 0.3511248921649449 0.12565219846665635 71.07402722475514 2554662.112193709 0.03698613290016762 0.044986487353530794 5.486004404014543e-07 6.260743848091598 -0.19429137705410215 EDS(ph)FVWY(ph)MDNPQNLPSGS(ph)SRVGAIK ddPTM_A459_Selumetinib_30min_R1 1 EDSFVWYMDNPQNLPSGSSRVGAIK 25 1 Q5RGS4;Q9HB21-2;R4GMZ9;Q9HB21 Q5RGS4;Q9HB21 PLEKHA1 Pleckstrin homology domain-containing family A member 1 3 EDS(0.998)FVWY(0.877)MDNPQNLPS(0.13)GS(0.498)S(0.498)RVGAIK 50.18899999999999 0.025425 19093000.0 1949.4 2290.1 1061.3 1381.1 4995.8 1274.8 3503.5 2122.1 73.444 666.5 True False 1994.817227127905 2021.9740273613936 917.1812893036074 1139.9168114578506 4543.930772080131 1261.9766694257903 3239.228174315969 2065.8150144477295 124.62910386247401 752.0517672597729 2.6524998862729317 2.688610166729341 1.2195720151626153 1.5157424808817739 6.042045202069941 1.67804494898538 4.307187769957169 2.7469053386775144 0.16571878331804354 1.0 9.554688162579842 -3.63671777824949 11.521039884109102 2.5346413349258903 2.5260188046334635 0.0 1.6430061910875817 0.0 0.0 0.36933186703121623 0.0 0.00023082466915458227 3.63671777824949 -0.008622530292426767 EDS(ph)GTFSLGK ddPTM_A459_Selumetinib_30min_R1 2 EDSGTFSLGK 10 0 G5E9Q4;O75569 G5E9Q4 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 1 EDS(0.998)GT(0.002)FSLGK;EDS(0.517)GT(0.07)FS(0.414)LGK 178.53 9.6856e-05 148168000.0 10446.3 10956.7 8014.8 7843.1 8174.900000000001 8289.8 10012.5 10433.5 4695.1 10165.1 True False 10689.678465038598 9673.884470368366 6926.434182145061 6473.449818221028 7435.481738395816 8206.412138536178 9257.24906389 10156.769687215681 7967.241783463616 11469.889601458846 0.9319774502170436 0.8434156566893157 0.6038797602083366 0.564386410257835 0.6482609682180466 0.7154743788896112 0.8070913832259186 0.8855159064411439 0.6946223599615352 1.0 13.485563884922861 -7.340507197492282 3.5305409198116395 0.8428733034413043 0.7077283443761831 0.20951131692063796 0.12338613102790891 0.45023317096919974 10.832264325252702 0.0596080061296692 0.03896883988954296 4.5655468373252676e-08 7.340507197492282 -0.13514495906512114 EDS(ph)GTFSLGK ddPTM_A459_Selumetinib_30min_R2 4 EDSGTFSLGK 10 0 G5E9Q4;O75569 G5E9Q4 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 1 EDS(0.857)GT(0.098)FS(0.045)LGK;EDS(0.524)GT(0.06)FS(0.416)LGK;EDS(0.94)GT(0.015)FS(0.045)LGK;EDS(0.9)GT(0.025)FS(0.075)LGK 147.58 0.00081938 197810000.0 810170.0 612870.0 751570.0 739680.0 658590.0 557930.0 548470.0 651840.0 508370.0 658150.0 True False 765143.9947674738 659875.1583123511 703214.8044475445 638934.3079808287 575852.0363306979 634779.7931157273 573974.941772687 653736.7464820796 610058.205044604 639147.4994209381 1.197132110288607 1.0324301650404517 1.100238685255987 0.9996664440676017 0.9009689263470713 0.9931663562649186 0.8980320540919008 1.0228261036370467 0.9544873532280285 1.0 19.285789382333853 -4.330123477337259 0.6860845865686998 0.9607367454871096 1.467438727515078 0.6504423420205103 0.050106990597549174 3.3075951598863518 0.7608375636331219 0.020961407697160803 1.5005265842042323 4.6760217510261456e-05 4.330123477337259 0.5067019820279683 EDS(ph)LRSHK ddPTM_A459_Selumetinib_30min_R1 2 EDSLRSHK 8 1 Q9NTW7-6;Q9NTW7-4;Q9NTW7-5 Q9NTW7-6 1 EDS(1)LRSHK;EDS(0.999)LRS(0.001)HK 99.136 0.010391 14002600.0 19353.9 29125.0 7697.5 6491.7 4806.0 14964.8 15469.400000000001 10287.8 7143.6 11190.2 True False 19804.808213866207 25715.03146015483 6652.2217793409145 5358.046459301229 4371.298148568218 14814.267698951257 14302.530703514609 10014.934124515983 12122.167452099136 12626.571171778416 1.5685024813491593 2.036580724118545 0.5268430905620095 0.42434690989403134 0.3461983533850016 1.1732613309987552 1.1327327513491645 0.7931634002824386 0.9600522015979548 1.0 13.624175298558349 -5.260666241060805 24.99998064825229 0.7835534492345292 1.8025416577033457 0.6571375372766827 0.29114422984662736 41.64059966000108 1346418.909016978 0.08244106927738931 0.19354639229535164 5.486984822999874e-06 5.260666241060805 1.0189882084688167 EDS(ph)PGPEVQPMDK ddPTM_A459_Selumetinib_30min_R1 1 EDSPGPEVQPMDK 13 0 O75382-3;O75382-2;O75382;E9PMW5;E9PMK8 O75382-3 TRIM3 Tripartite motif-containing protein 3 1 EDS(1)PGPEVQPMDK 246.77 1.0438e-22 2327800.0 1348.2 1659.4 1290.5 1834.2 1176.2 1160.4 1216.0 1551.8 950.08 1262.4 True False 1379.6104368594652 1465.1166765658697 1115.2571882090874 1513.8914021982405 1069.8129176749767 1148.7274295589013 1124.2761409927832 1510.6412230432063 1612.2163689022836 1424.441336817311 0.9685273806655925 1.0285552930101294 0.7829435718995303 1.0627965947553808 0.7510403482570259 0.8064406724713222 0.7892751438292296 1.060514872741966 1.1318236330493794 1.0 10.476180492616965 -7.833084812595465 8.517232057157702 1.0740077456559725 0.8847759344912108 0.37713652853448143 0.10575238210081792 0.30375153841897545 32.37434608159294 0.059275671236185226 0.028424347435524983 1.4686394416574648e-08 7.833084812595465 -0.18923181116476162 EDS(ph)PGPEVQPMDK ddPTM_A459_Selumetinib_30min_R2 2 EDSPGPEVQPMDK 13 0 O75382-3;O75382-2;O75382;E9PMW5;E9PMK8 O75382-3 TRIM3 Tripartite motif-containing protein 3 1 EDS(1)PGPEVQPMDK;EDS(1)PGPEVQPMDK 182.37 0.00011758 7558400.0 56481.0 44368.0 53609.0 51436.0 48819.0 39417.0 49832.0 57089.0 38062.0 46133.0 True False 53342.01213135729 47770.88293439454 50159.855305065925 44430.32806795088 42685.920772602585 44846.333958099785 52149.28674023471 57255.1195384073 45675.463541136894 44801.02042207114 1.1906427940440045 1.0662900640285484 1.1196141255826122 0.9917258055591601 0.9527890295903494 1.001011439819936 1.1640200658140247 1.277986952060598 1.0195183750465417 1.0 15.45124397212465 -9.794847681702137 13.323727496426526 0.9999999919687808 1.0860068657968398 0.06778349672702322 0.09679366849309609 0.0 0.0 0.10123453371096525 0.024552980908850684 1.60380778889773e-10 9.794847681702137 0.08600687382805905 EDS(ph)RGSLIPEGATGFPDQGNTGENTR ddPTM_A459_Selumetinib_30min_R1 1 EDSRGSLIPEGATGFPDQGNTGENTR 26 1 A0A0J9YW64;A6NIW2;Q5JSL3 A0A0J9YW64 DOCK11 Dedicator of cytokinesis protein 11 1 EDS(0.591)RGS(0.409)LIPEGATGFPDQGNTGENTR 83.31700000000002 6.090100000000001e-05 4457900.0 373.29 332.38 397.14 458.97 323.81 421.95 387.19 290.3 137.53 344.89 True False 381.9869307041019 293.4647950807302 343.2105693338685 378.81950543393634 294.5214426732986 417.70556609994685 357.98394657154284 282.6003009727045 233.3783652062258 389.159991013088 0.9815678372015768 0.7540980621280273 0.8819266555135823 0.9734287033149718 0.7568132631172597 1.073351772397124 0.9198888756257149 0.7261802536201627 0.5996977351106397 1.0 8.604219586085932 -7.760644094537426 24.999971735000496 0.7472042169666918 0.9024170862059936 0.1635741270006621 0.13059715753146992 31.29362811157387 983836.6349967846 0.06318687614281329 0.033710550679468584 1.7352254370171434e-08 7.760644094537426 0.15521286923930178 EDSAPPS(ph)SVAR ddPTM_A459_Selumetinib_30min_R2 1 EDSAPPSSVAR 11 0 Q9BZE4-2;Q9BZE4;Q9BZE4-3 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 1 EDS(0.001)APPS(0.794)S(0.205)VAR 130.1 0.002459 10249000.0 41420.0 36128.0 41947.0 43561.0 43165.0 39641.0 39143.0 39587.0 37637.0 32574.0 True False 39118.04221739733 38898.90143017054 39248.17568844038 37627.91665308361 37742.226800003875 45101.187924830294 40963.22706038304 39702.191616019336 45165.45166564473 31633.503982583923 1.2366016183010924 1.229674128151805 1.2407154044663777 1.1894956901960643 1.1931092686027813 1.4257411366651356 1.294931699091434 1.2550677799676473 1.4277726454366526 1.0 14.949165748819572 EDSAPPSS(ph)VAR ddPTM_A459_Selumetinib_30min_R1 1 EDSAPPSSVAR 11 0 Q9BZE4-2;Q9BZE4;Q9BZE4-3 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 1 EDS(0.017)APPS(0.342)S(0.641)VAR 134.75 0.0015689 7243800.0 3345.1 4607.4 3398.4 3961.2 3485.6 3502.1 4046.2 2942.4 2229.6 2533.3 True False 3423.0343215684607 4067.9634660778524 2936.915946074981 3269.450780933197 3170.328095432663 3466.872053652382 3740.99187638569 2864.3579937378095 3783.46835645896 2858.4737314316344 1.1975042079026113 1.42312431328185 1.0274419924803926 1.1437749960695736 1.1090982087999948 1.212840270501992 1.3087375389355271 1.002058532930169 1.3235973851556273 1.0 11.48102931703365 -11.751056799915295 2.37605929869378 0.33659597249964474 1.1903414164005255 0.17697937693648014 0.1254096241028413 1521536.0600731734 1092239.9493009348 5345494.722255071 0.0327885770260642 1.7739574557855787e-12 11.751056799915295 0.8537454439008807 EDSCHRLS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 EDSCHRLSPVK 11 1 Q9Y2L9-2;Q9Y2L9;Q9Y2L9-3 Q9Y2L9-2 LRCH1 Leucine-rich repeat and calponin homology domain-containing protein 1 1 EDS(0.001)CHRLS(0.999)PVK 63.426 0.047593 14125000.0 56444.0 36693.0 51898.0 78229.0 88527.0 61441.0 82525.0 89258.0 98437.0 70151.0 True False 53307.06844323457 39507.23511340917 48558.93918227001 67574.07524744776 77405.4468185785 69903.9400441335 86362.57602018517 89517.72600254262 118127.15055958438 68125.55835581289 0.7824826647998562 0.5799179642252161 0.7127859257850276 0.9919049014543884 1.136217429797752 1.0261044713796297 1.267697147803504 1.3140108963951622 1.7339623103361332 1.0 16.055908528676632 -6.319518706495574 0.7530402951013274 1.3655646167924893 0.6257722986436155 0.6451272331472335 0.1888351030178467 0.4339412557150556 0.5362420496442714 0.1113501491971463 0.18228747312013316 4.791608134272869e-07 6.319518706495574 -0.7397923181488738 EDSGDAEAHAFKS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 EDSGDAEAHAFKSPSK 16 1 Q9NPI1-2;Q9NPI1 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 1 EDS(0.001)GDAEAHAFKS(0.911)PS(0.088)K 55.173 0.039649 3898600.0 47218.0 33327.0 43403.0 43961.0 48723.0 40097.0 45493.0 43079.0 31147.0 39053.0 True False 44593.81258863032 35883.07373680506 40610.49823361335 37973.43596304513 42601.98115085343 45619.997785674415 47608.514642669346 43204.35275788764 37377.27031989364 37925.438418120284 1.1758285322108226 0.9461478952781359 1.070798385661118 1.0012655765345593 1.123308864123737 1.2028864975197695 1.2553187683104703 1.1391919133951305 0.98554616317989 1.0 15.210878237674812 -6.370946001166095 6.328417865950225 1.1368340580322664 1.0431103113773286 0.09410950612283453 0.09466102775694007 0.4328352898412216 21.714769644362963 0.029718086673735884 0.033716229192282295 4.256513340152697e-07 6.370946001166095 -0.09372374665493788 EDSGLFS(ph)PIR ddPTM_A459_Selumetinib_30min_R1 4 EDSGLFSPIR 10 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 EDSGLFS(1)PIR;EDSGLFS(1)PIR;EDSGLFS(1)PIR;EDSGLFS(1)PIR 158.56 0.00047333 60269000.0 11872.599999999999 12796.5 13382.3 14074.0 14592.0 11543.0 13141.8 13299.3 7433.6 10388.199999999999 True False 12149.208479941912 11298.279831068552 11565.057163712112 11616.240101699945 13272.156176426839 11426.887900205442 12150.50344547612 12946.559361785361 12614.276271337172 11721.62665963687 1.0364780275571657 0.9638832697149362 0.986642681901489 0.9910092207338577 1.1322793808242655 0.9748551316306334 1.0365885041635114 1.1045019379747452 1.0761540729474108 1.0 13.516885172086738 -6.1111900947212225 20.475500779794384 1.055111618435868 0.9917085993329933 0.28308418343653297 0.04632907637479573 7.835467908571136 1427.1101791906851 0.013569368874248467 0.017518051174676457 7.741228828718337e-07 6.1111900947212225 -0.06340301910287471 EDSGLFS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 3 EDSGLFSPIR 10 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 EDSGLFS(1)PIR;EDS(0.001)GLFS(0.999)PIR;EDSGLFS(1)PIR 142.19 0.0012261 31150800.0 67497.5 65401.8 72949.7 81174.1 89528.5 77105.8 76063.5 76944.5 70935.6 86878.2 True False 63746.25916390089 70417.90776006777 68256.19572362775 70118.04754686709 78281.12943505491 87726.42405323724 79600.60346696594 77168.39575615231 85124.70210626523 84369.80062932799 0.7555577788308996 0.834634042451318 0.8090121727738332 0.8310799246157421 0.9278335239759168 1.0397846551594485 0.9434726984443742 0.914644756542516 1.0089475318337404 1.0 16.364439071860595 -6.299289643896145 2.8339182228756554 0.9745028476674551 0.8053988741099825 0.8238163429781356 0.0380165455071014 0.11540400302066349 1.8474827108178193 0.012562592999467156 0.015336567883103475 5.020076740160143e-07 6.299289643896145 -0.16910397355747264 EDSGSS(ph)SPPGVFLEK ddPTM_A459_Selumetinib_30min_R1 1 EDSGSSSPPGVFLEK 15 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 EDS(0.044)GS(0.009)S(0.474)S(0.474)PPGVFLEK 142.57 0.00038089 11885000.0 2257.7 2372.4 1933.8 1954.1 2532.8 1938.5 2344.2 2209.9 998.32 1889.7 True False 2310.3000172805346 2094.638305101162 1671.2005816030485 1612.8531179999889 2303.708687202159 1919.0004500171754 2167.375106673753 2151.2862732331387 1694.0761255920843 2132.26140223675 1.0834975556266324 0.9823553073295229 0.7837690912802496 0.756404968128251 1.0804063164045272 0.8999836736734702 1.0164678235042703 1.0089223914931027 0.794497393150292 1.0 11.058168599210001 -6.2770286775799 24.989950313208006 0.9663103190509276 0.8988717777411702 0.07417722016578898 0.11269648254022714 2444.2795079517155 3918220.0378218587 0.03655294109129909 0.04158507052351436 5.284103583302326e-07 6.2770286775799 -0.06743854130975735 EDSGSS(ph)SPPGVFLEK ddPTM_A459_Selumetinib_30min_R2 2 EDSGSSSPPGVFLEK 15 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 EDSGSS(0.5)S(0.5)PPGVFLEK;EDS(0.001)GS(0.004)S(0.498)S(0.498)PPGVFLEK 204.23 7.0574e-06 16633000.0 54116.0 40734.0 46346.0 53037.0 50936.0 44730.0 50449.0 50053.0 46684.0 49927.0 True False 51108.44936351218 43858.16681954623 43364.14881770946 45813.26910607182 44536.96430638246 50891.151481487796 52794.97846279703 50198.6459432798 56022.10445994522 48485.4777840753 1.0540980866707759 0.9045629500623613 0.8943739610203881 0.9448864113517894 0.9185629665179932 1.0496163760234745 1.0888822978689332 1.03533363467787 1.1554409076761798 1.0 15.565265080123611 -6.834827022013436 5.060355172189862 1.0719704980502138 0.9385525882868834 0.5491071899377729 0.05554447937013944 0.1488563669866012 6.958635036457744 0.01922469211518882 0.017094913755438906 1.4627596705517297e-07 6.834827022013436 -0.13341790976333046 EDSGSS(ph)SPPGVFLEKDYEIYR ddPTM_A459_Selumetinib_30min_R1 1 EDSGSSSPPGVFLEKDYEIYR 21 1 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 EDS(0.005)GS(0.1)S(0.454)S(0.441)PPGVFLEKDYEIYR 102.59 0.0001151 7300300.0 1475.5 1026.3 2915.4 3217.1 2176.5 2025.0 1292.9 1082.5 834.78 694.53 True False 1509.8762791767845 906.1403188860745 2519.5046931458933 2655.2938774462746 1979.6359592922847 2004.6303385528906 1195.3755120802375 1053.7885835444465 1416.560690081096 783.679690795094 1.9266497485023721 1.1562636234285162 3.21496744491323 3.3882387264014797 2.5260779149244197 2.5579715310971793 1.5253368514213395 1.3446674654479174 1.8075761139655198 1.0 9.614120299566519 -7.286619338917352 6.197632781725877 1.4412613539575667 2.482572201889464 0.4082049697504737 0.6144854709035545 0.2174295917755694 30.741643193205686 0.28357986119914025 0.19538071976218985 5.1686920899041206e-08 7.286619338917352 1.0413108479318973 EDSGSSS(ph)PPGVFLEK ddPTM_A459_Selumetinib_30min_R1 2 EDSGSSSPPGVFLEK 15 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 EDSGSS(0.113)S(0.886)PPGVFLEK;EDS(0.001)GS(0.003)S(0.006)S(0.99)PPGVFLEK 152.34 0.00022896 15139500.0 6834.9 7293.299999999999 5664.5 6191.299999999999 7138.200000000001 6746.299999999999 7120.0 7062.1 3416.35 6197.6 True False 6994.139871599733 6439.397045436813 4895.292012871269 5110.105680094843 6492.551070351573 6678.438347150306 6582.9326676551145 6874.790167066268 5797.296429668358 6993.122329736191 1.0001455060866324 0.9208185902962365 0.7000152123830986 0.7307330601619286 0.9284194904962427 0.9550009326666882 0.94134384574729 0.9830787798224621 0.8289997166240126 1.0 12.77172102693856 -6.484836536119868 23.325500086336394 0.9407285185213012 0.8334451407142057 0.2327770967457934 0.0904270465785097 395.2594159407303 242351.96988043777 0.03009988928789106 0.03411804671072471 3.2746392566716184e-07 6.484836536119868 -0.10728337780709551 EDSGSSS(ph)PPGVFLEKDYEIYR ddPTM_A459_Selumetinib_30min_R1 1 EDSGSSSPPGVFLEKDYEIYR 21 1 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 EDS(0.002)GS(0.018)S(0.076)S(0.903)PPGVFLEKDYEIYR 97.776 0.00019185 9490500.0 3104.8 2201.1 5920.1 6025.6 4123.9 3787.0 2679.5 2816.4 1634.5 1656.5 True False 3177.1357991108644 1943.394188736371 5116.182936781573 4973.342074520615 3750.893973133681 3748.9062183208875 2477.383157722175 2741.6999230434885 2773.6271208432804 1869.1279106763902 1.6997958143812315 1.0397331170519548 2.737203220581172 2.6607820931425117 2.006761523226266 2.0056980567821348 1.325421948691394 1.4668337610192426 1.4839150948420512 1.0 10.868149585571883 -7.247536418665008 6.8972531511178845 1.356844244118651 2.0420325839661055 0.3563986774918849 0.4633358515369477 0.20860050458169802 54.399660968753516 0.20110635470134997 0.14896972053349292 5.655403305426553e-08 7.247536418665008 0.6851883398474545 EDSGSVPSTGPSQGT(ph)PISLK ddPTM_A459_Selumetinib_30min_R2 1 EDSGSVPSTGPSQGTPISLK 20 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 EDSGSVPSTGPS(0.025)QGT(0.777)PIS(0.198)LK 145.05 6.4591e-05 4501400.0 23232.0 15408.0 19575.0 22304.0 22403.0 23766.0 26778.0 23467.0 21645.0 21501.0 True False 21940.85844506458 16589.744055471307 18315.565811648532 19266.156723453925 19588.534854638867 27039.55077373213 28023.23005960036 23535.28508482902 25974.60481183093 20880.210263693054 1.050796815165018 0.7945199711095774 0.8771734374483776 0.9226993636627463 0.9381387738561149 1.2949846017953692 1.3420952042962775 1.127157475313008 1.2439819563022367 1.0 14.349848619467778 -6.707560791904834 6.810577852712707 1.2180980714799503 0.9059119471995513 0.6404774377147548 0.10632404868497772 0.12204433222745455 11.99338915095506 0.034502523513463494 0.03421521315896681 1.9608266826207833e-07 6.707560791904834 -0.31218612428039905 EDSGSVPSTGPSQGTPIS(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 EDSGSVPSTGPSQGTPISLK 20 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 EDSGSVPS(0.001)T(0.007)GPS(0.011)QGT(0.023)PIS(0.958)LK 197.0 1.5458e-15 6329500.0 72548.0 53980.0 51651.0 65488.0 67582.0 74294.0 74909.0 79536.0 66514.0 65524.0 True False 68516.07259265427 58120.09242694328 48327.83089335669 56568.421426898836 59091.74496925431 84527.32412621635 78392.41692936746 79767.43659210639 79818.65855643897 63632.151868202556 1.0767524055224076 0.9133761898752681 0.7594876092428119 0.8889911745255071 0.9286460261731755 1.3283744403504176 1.2319623748028663 1.2535712568282127 1.2543762266874543 1.0 15.957468290029395 -6.717624276280476 8.43964260623469 1.230479423113309 0.9025895534608673 0.6590749922835402 0.10749029730523725 0.15229208511242426 26.479444658182558 0.03528660142727531 0.0350793417965428 1.9159127329990874e-07 6.717624276280476 -0.3278898696524416 EDSQRPGAHLTVK ddPTM_A459_Selumetinib_30min_R2 1 EDSQRPGAHLTVK 13 1 F8W6I7;P09651-2;P09651;P09651-3;F8VZ49;F8W646;Q32P51;F8VYN5 F8W6I7 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 70.628 0.048028 27710000.0 82576.0 79084.0 121060.0 144240.0 151730.0 99225.0 93042.0 91827.0 102120.0 128900.0 False True 77986.75649791902 85149.48850486086 113271.13140016179 124594.2631721212 132668.32091658964 112892.34307513147 97368.63735922547 92094.20136722176 122546.85347120209 125178.3220775796 0.6230052872060908 0.6802255142235348 0.9048781731549469 0.9953341848990719 1.059834632024929 0.9018521833609987 0.777839451297973 0.7357040727079416 0.9789782402998927 1.0 16.93362521770551 -5.221102020471256 3.9727478478226947 0.9129364974991591 0.63817050624186 0.5607281407452114 0.09515474853756423 0.182241213609975 6.27747424294722 0.02794823538161867 0.07920770498772195 6.010325318558852e-06 5.221102020471256 -0.27476599125729906 EDSSGMHHENQTYPPYS(ph)PQAQPQPIHR ddPTM_A459_Selumetinib_30min_R2 2 EDSSGMHHENQTYPPYSPQAQPQPIHR 27 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 EDSSGMHHENQTYPPY(0.448)S(0.552)PQAQPQPIHR;EDSSGMHHENQTYPPY(0.115)S(0.885)PQAQPQPIHR 115.54 4.4224e-12 34047000.0 32770.0 20669.9 51228.0 51278.0 58415.0 42458.0 45866.0 45744.0 54019.0 56021.0 True False 30948.774588703785 22255.214865796115 47932.04625282914 44293.84794051607 51076.38546327414 48306.20410465035 47998.85988175483 45877.107466673166 64824.309416969016 54403.52816996179 0.5688744026309631 0.40907668334062286 0.8810466501930697 0.8141723419506521 0.9388432548658731 0.8879241058362461 0.8822747622507465 0.8432744899071384 1.1915460558817383 1.0 15.731412595515016 -5.3063693788023185 6.266451154300359 0.9188147445599496 0.48908514348873783 0.7307595086760807 0.10691729337215547 0.09265855237711801 9.651163145019568 0.027345256851096785 0.05902409308157039 4.938904415744212e-06 5.3063693788023185 -0.4297296010712118 EDSSVASSDRSS(ph)VER ddPTM_A459_Selumetinib_30min_R1 1 EDSSVASSDRSSVER 15 1 O14867 O14867 BACH1 Transcription regulator protein BACH1 1 EDSSVASSDRS(0.004)S(0.996)VER 172.09 0.00019656 3192700.0 1415.0 1445.5 1388.2 1425.8 1783.0 1393.1 1971.7 1505.2 833.91 1188.7 True False 1447.9667468892915 1276.2601880052819 1199.6900648367732 1176.8107955807714 1621.7279648142166 1379.0866788335957 1822.973081575224 1465.2772064213389 1415.0843636233817 1341.2812239185175 1.0795400107511346 0.9515231893552656 0.8944358896875559 0.877378117724447 1.2090886951182254 1.0281860762984742 1.3591281597527 1.0924459243085283 1.055024359089476 1.0 10.389396040783176 -6.260677195449954 24.999886342640476 1.135568991372382 0.9467564766549466 0.37456889919189507 0.10901648126267824 69.75771941530866 2288070.0011663963 0.03284348158613762 0.039904793376755815 5.48684642426014e-07 6.260677195449954 -0.18881251471743554 EDTDHEEKAS(ph)NEDVTK ddPTM_A459_Selumetinib_30min_R1 2 EDTDHEEKASNEDVTK 16 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 EDTDHEEKAS(0.998)NEDVT(0.002)K;EDTDHEEKAS(0.992)NEDVT(0.008)K 78.40100000000002 0.014453 54171000.0 12398.2 16564.8 10919.400000000001 10942.3 10016.5 12609.0 13603.8 13445.5 8248.1 15201.6 True False 12687.053937302344 14625.385515233409 9436.605455970792 9031.43271741021 9110.509343556703 12482.164908056006 12577.654413517781 13088.881662860826 13996.423282610856 17152.873436123286 0.7396459831962556 0.8526492992382789 0.5501472095105457 0.526525934622147 0.5311360442018026 0.727701102356941 0.7332680708195356 0.7630722462684385 0.8159812602088541 1.0 14.066162655352853 -8.40574941287418 0.8341149863248807 0.9943569034723655 0.6491066799879563 0.5401993589947824 0.09814121607487103 0.5337778856650839 0.828937382066232 0.1060602799507573 0.03901722333474976 3.928715561864764e-09 8.40574941287418 -0.34525022348440915 EDTDHEEKAS(ph)NEDVTK ddPTM_A459_Selumetinib_30min_R2 2 EDTDHEEKASNEDVTK 16 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 EDTDHEEKAS(0.767)NEDVT(0.233)K;EDTDHEEKAS(0.998)NEDVT(0.002)K 127.37 0.00057379 67404000.0 175943.0 126683.0 125384.0 131070.0 118338.0 104950.0 154441.0 165791.0 102242.0 100126.0 True False 166164.7924156333 136399.17874995273 117316.92994777705 113218.03989163882 103471.32248485729 119405.90985875565 161622.81251903577 166273.42436182234 122693.25688016736 97235.10222140979 1.708897184447513 1.4027771415240984 1.2065285814236077 1.1643741540358026 1.0641354831843266 1.2280123857623113 1.662185865254829 1.7100143936004553 1.2618206190680803 1.0 16.569189605507212 -7.2267949934885385 24.935373515429866 1.4676732185807397 1.280090446697512 0.023463753637471663 0.2499470975432354 1399.6926008177297 1007433.0117345363 0.09782624445938422 0.07577306653024532 5.9320527804775e-08 7.2267949934885385 -0.1875827718832277 EDTEEHHLR ddPTM_A459_Selumetinib_30min_R1 3 EDTEEHHLR 9 0 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8VZ49;Q32P51;A0A2R8Y4L2;F8VYN5;P22626;P22626-2;A0A087WUI2 F8W6I7;P22626 HNRNPA1;HNRNPA1L2;HNRNPA2B1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2;Heterogeneous nuclear ribonucleoproteins A2/B1 0 ;; 166.09 0.0013100999999999998 44412350.0 15817.310000000001 20036.93 12484.8 9880.130000000001 13205.689999999999 16853.36 13250.99 17019.33 14865.02 15644.05 False True 16185.822547872425 17690.996920683963 10789.432734097492 8154.750768509918 12011.237671153927 16683.83050002653 12251.457155866747 16567.922081824938 25224.853241895224 17652.116203451234 0.9169338316902691 1.002202609408674 0.6112260201407471 0.46197014989712964 0.6804417970467226 0.9451461970754877 0.6940503345129473 0.9385799351686615 1.4289988209438262 1.0 14.107553529233579 -8.029222375154548 5.137734099488614 1.213068035237691 0.757829016413015 0.49674042483742775 0.18221032055870096 0.16402771383580958 11.614805391964925 0.1286133260157335 0.05012817070616013 9.349268337653373e-09 8.029222375154548 -0.455239018824676 EDTEEHHLR ddPTM_A459_Selumetinib_30min_R2 4 EDTEEHHLR 9 0 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8VZ49;Q32P51;A0A2R8Y4L2;F8VYN5;P22626;P22626-2;A0A087WUI2 F8W6I7;P22626 HNRNPA1;HNRNPA1L2;HNRNPA2B1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2;Heterogeneous nuclear ribonucleoproteins A2/B1 0 ;;; 164.68 0.0013751 339535280.0 1103624.39 893449.7999999999 758372.2999999999 964673.6 944450.2899999999 990980.5199999999 1515718.8599999999 2062355.9 1350249.1 1590537.29 False True 1042289.364562274 961974.5267660965 709579.4518713278 833283.3915252218 825800.0010774805 1127479.091404507 1586202.790329944 2068357.0142276022 1620336.6491120555 1544614.345725522 0.6747893850957984 0.6227926921876714 0.4593893963467177 0.5394766621397781 0.5346318343881452 0.7299421337919259 1.0269248079428446 1.339076656870018 1.0490234365594773 1.0 20.558815245019346 -7.209375109448825 2.4755355042682647 1.150765377277516 0.5643311270787499 0.8636094920158319 0.10116355966498015 0.09618327414408341 1.1573799143931673 0.04590449692293778 0.03169311997620174 6.174828365908544e-08 7.209375109448825 -0.586434250198766 EDTEEYNLR ddPTM_A459_Selumetinib_30min_R2 1 EDTEEYNLR 9 0 P51991;P51991-2 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 134.77 0.038838 4692100.0 23220.0 18503.0 24874.0 28436.0 19275.0 21314.0 17020.0 24688.0 24122.0 17339.0 False True 21929.525357024784 19922.120603477797 23273.633920763485 24562.967745163918 16853.502179313673 24249.810030771994 17811.463724490186 24759.83799268157 28947.074024993537 16838.378017867715 1.3023537857241771 1.1831377453539662 1.3821778971862446 1.4587490386009512 1.0008981958612586 1.4401511835070921 1.0577897530029259 1.4704407969941138 1.7191129688546556 1.0 14.0394655548731 -7.861757966473063 22.165859028262695 1.446110643163528 1.2666811096867348 0.06116572749893834 0.21840195413769184 12.146855300283999 2662.383496744662 0.11205777581875495 0.0538307024775348 1.374807945859339e-08 7.861757966473063 -0.17942953347679325 EDTKMS(ph)ISEGTVSDK ddPTM_A459_Selumetinib_30min_R2 1 EDTKMSISEGTVSDK 15 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EDT(0.073)KMS(0.884)IS(0.027)EGT(0.014)VS(0.001)DK 64.346 0.038033 5875100.0 40298.0 36312.0 50615.0 51283.0 46871.0 42732.0 34755.0 44717.0 41118.0 49906.0 True False 38058.39848567548 39097.013638517295 47358.4860054452 44298.16693189057 40982.64594794352 48617.945117526 36371.17636572601 44847.11906670213 49342.74893291121 48465.084108639814 0.7852745782997796 0.8067047516285547 0.9771671065149902 0.9140222852516124 0.8456117780808223 1.003154044023601 0.7504614308353622 0.925349040273455 1.0181092190473457 1.0 15.564658134598472 -1.5228787452803396 0.10144144885540177 1.0481638250639638 0.40037514667144897 0.276925221598896 0.0799966322881443 197.0555757551511 1.4190964854164114 1.0127672740328975 17.773174673292086 0.029999999999999857 1.5228787452803396 -0.6477886783925149 EDVEVAES(ph)PLR ddPTM_A459_Selumetinib_30min_R1 3 EDVEVAESPLR 11 0 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 EDVEVAES(1)PLR;EDVEVAES(1)PLR;EDVEVAES(1)PLR 201.38 1.8746e-05 185711000.0 8735.2 10367.0 9173.5 9798.0 8656.8 8390.6 10246.899999999998 8682.1 4640.9 7237.799999999999 True False 8938.713164259614 9153.22682051245 7927.789086428563 8086.963231238882 7873.793968482178 8306.19818205525 9473.968083173482 8451.822504564652 7875.26834207499 8166.842132142216 1.0945127895982645 1.1207792035661033 0.9707288273918248 0.9902191202412308 0.9641173223482931 1.017063639489806 1.1600528000763985 1.034894806072085 0.9642978540114447 1.0 12.99556262484618 -5.24792983805638 24.42414149150412 1.0168025281474558 1.107646014650053 0.3239226407000818 0.05462349788910238 771.6405326320474 1395054.6600470406 0.015253862209290392 0.0397933539676792 5.650282499257588e-06 5.24792983805638 0.09084348650259733 EDVEVAES(ph)PLR ddPTM_A459_Selumetinib_30min_R2 2 EDVEVAESPLR 11 0 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 EDVEVAES(1)PLR;EDVEVAES(1)PLR 153.49 0.00055963 209345000.0 115366.0 111921.0 138030.0 152662.0 145704.0 110937.0 119552.0 111545.0 108270.0 121985.0 True False 108954.41956668919 120504.98081726387 129149.30007570097 131869.17224336124 127399.3609097131 126217.56476418102 125111.40488779377 111869.57748273107 129927.02531655965 118462.97609490728 0.9197339384703601 1.0172374930098045 1.090208133655466 1.1131678148767217 1.0754360991880398 1.0654600190278953 1.0561224191055276 0.944342115743455 1.09677326705407 1.0 16.85407671035086 -4.825037157969136 3.228682156383833 1.0563554930155241 0.9069775278341063 0.42768836067819305 0.04721248188741718 0.2951799461369742 4.939477598499692 0.0124527033334305 0.1054446689266313 1.4961076445670316e-05 4.825037157969136 -0.14937796518141777 EDVEVVGGS(ph)DGEGAIGLSSDPK ddPTM_A459_Selumetinib_30min_R1 1 EDVEVVGGSDGEGAIGLSSDPK 22 0 Q8NHZ8 Q8NHZ8 CDC26 Anaphase-promoting complex subunit CDC26 1 EDVEVVGGS(1)DGEGAIGLSSDPK 95.366 0.00014331 2295700.0 1618.8 1976.5 1830.1 1793.2 1850.9 1882.1 1538.4 1646.7 982.53 1588.8 True False 1656.5148903635231 1745.0904611500796 1581.582472019721 1480.0512825329208 1683.4864218029354 1863.1677828100715 1422.3572494270536 1603.0241667645619 1667.2816488480555 1792.7379562225472 0.9240139556446623 0.9734219410555323 0.882216202613488 0.8255814952741426 0.9390588378851452 1.0392861803048594 0.7933994170704582 0.8941765087309644 0.9300197181975001 1.0 10.80794891013188 -5.261168761885447 24.726626914464664 0.9072399122035797 0.9487179444924256 0.03495214315024364 0.07015496010006743 69.20630533555496 6322574.23743636 0.01840150238049532 0.04277189938139817 5.480639521315648e-06 5.261168761885447 0.041478032288845945 EDVT(ph)PPLSPDDLK ddPTM_A459_Selumetinib_30min_R1 1 EDVTPPLSPDDLK 13 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 EDVT(0.854)PPLS(0.146)PDDLK 100.11 0.026179 4028000.0 3547.8 4034.0 2281.8 2381.9 2797.4 2639.6 2936.3 2740.5 1506.5 3109.9 True False 3630.4568371829205 3561.697404644281 1971.9440930302171 1965.9458788005606 2544.375663921085 2613.048020565042 2714.812526971308 2667.8130376014356 2556.420469593391 3509.085957991251 1.034587605047198 1.014992920459306 0.5619537727594001 0.5602444346863339 0.7250821707934432 0.7446520409721913 0.7736523298293273 0.7602586740646856 0.7285146332114344 1.0 11.776879572854948 -5.237486942898394 22.149682854321266 0.7188201716114422 1.024790873821465 0.502727595884715 0.115987763056054 143.54154045346027 132735.0115325418 0.029467918577759062 0.07779861977378849 5.787793891405284e-06 5.237486942898394 0.30597070221002287 EDVT(ph)PPLSPDDLK ddPTM_A459_Selumetinib_30min_R2 1 EDVTPPLSPDDLK 13 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 EDVT(0.741)PPLS(0.259)PDDLK 95.428 0.035091000000000004 2775100.0 28325.0 21320.0 21137.0 27806.0 28756.0 21186.0 24361.0 25520.0 15406.0 16470.0 True False 26750.809893958944 22955.175445395143 19777.068432225533 24018.77483197453 25143.41419809826 24104.179192640302 25493.834770405734 25594.258974936554 18487.630479605774 15994.468305800861 1.672503854614347 1.4351946564594322 1.236494271275826 1.501692608516622 1.5720068787143906 1.5070322271293142 1.5939157390533356 1.6001944225713367 1.1558765271928855 1.0 13.96528541418285 -8.417344603112785 4.0117643685294295 1.0057789943666169 1.5059089564184218 0.7098081922585131 0.11342489068138267 0.12312410070508731 3.2604006641330874 0.11706813797119368 0.03078592545697203 3.825211007915447e-09 8.417344603112785 0.5001299620518049 EDVTKDADLS(ph)PVNASIIK ddPTM_A459_Selumetinib_30min_R1 1 EDVTKDADLSPVNASIIK 18 1 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 EDVTKDADLS(0.995)PVNAS(0.005)IIK 86.85600000000002 0.003904 4884200.0 1419.9 1348.5 2866.9 2729.3 2028.3 1816.4 1659.2 1833.4 1318.5 1248.6 True False 1452.980907355552 1190.6169930993583 2477.5907267544612 2252.6789903062127 1844.8406231254487 1798.128665159244 1534.045208170417 1784.7722762774936 2237.398200570122 1408.869972393928 1.0313094436150636 0.8450864994136272 1.7585659253881187 1.598926114152677 1.3094470456991334 1.2762914253214541 1.0888479691023532 1.2668112112893135 1.5880799821209708 1.0 10.460322753059998 -9.900199552722402 15.158112302918303 1.000000983329097 1.3068845011374945 0.10706040728330901 0.26601928854509954 0.0 0.0 0.2739183402291588 0.06643495585639396 1.2583470846546487e-10 9.900199552722402 0.3068835178083975 EDYDS(ph)VEQDGDEPGPQR ddPTM_A459_Selumetinib_30min_R2 1 EDYDSVEQDGDEPGPQR 17 0 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 1 EDYDS(1)VEQDGDEPGPQR 183.71 5.987999999999998e-14 0.0 12596.0 13358.0 15156.0 14394.0 15939.0 11851.0 12867.0 11117.0 11795.0 15391.0 True False 11895.964745783118 14382.515647260245 14180.879460605116 12433.512368965023 13936.600323532071 13483.36767733315 13465.340995476805 11149.348629481583 14154.329579835781 14946.621839379555 0.7958965493086247 0.9622586161487627 0.9487681974560329 0.8318610387403196 0.932424762819221 0.9021013458578848 0.9008952752119512 0.7459443845770303 0.9469918843162046 1.0 13.867531830107106 EEAAT(ph)GGGSTGEADGK ddPTM_A459_Selumetinib_30min_R1 1 EEAATGGGSTGEADGK 16 0 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 EEAAT(0.888)GGGS(0.108)T(0.004)GEADGK 291.13 2.6026999999999993e-74 6763100.0 2799.2 3278.1 1757.5 1675.2 2284.3 2461.2 3183.2 3591.3 1421.2 2915.1 True False 2864.41591370495 2894.2985280526545 1518.841153256468 1382.6577673985882 2077.685468325922 2436.442562590803 2943.0886611909787 3496.047057813551 2411.672599658896 3289.2814804785658 0.870833320500196 0.879918166088831 0.4617546908863172 0.42035252245953175 0.631653289831442 0.7407218193550036 0.8947512332580249 1.0628604084393842 0.7331913106165715 1.0 11.683556756841005 -7.148634232318197 2.751107532935041 0.931847419458568 0.6439533810953396 0.39108006842699083 0.15898479054467599 0.3170673936806597 4.64924065524609 0.07514975306001892 0.05498566129096931 7.101756340445012e-08 7.148634232318197 -0.28789403836322836 EEAATGGGS(ph)TGEADGK ddPTM_A459_Selumetinib_30min_R2 2 EEAATGGGSTGEADGK 16 0 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 EEAAT(0.028)GGGS(0.799)T(0.173)GEADGK;EEAAT(0.013)GGGS(0.851)T(0.136)GEADGK 205.12 1.6302e-07 18843200.0 75662.0 51883.0 56307.0 65263.0 58789.0 52230.0 78015.0 86319.0 67980.0 48750.0 True False 71457.00893898398 55862.259269860995 52684.26892242619 56374.06681504543 51403.4002396717 59424.208403266464 81642.85208378987 86570.17399912018 81577.8995199014 47342.46083228853 1.5093640609879078 1.1799610389445956 1.1128333423364092 1.1907717897206804 1.0857779535746803 1.2551989769559662 1.7245164414458947 1.8285947218881689 1.7231444687442947 1.0 15.53084707798083 -7.206269749317473 6.073281656410682 1.6377572428656468 1.205274404600172 0.31825280044139703 0.23995213750401798 0.20772333957029518 17.184497548794404 0.08928571580279385 0.06830577472845482 6.219138815588673e-08 7.206269749317473 -0.43248283826547484 EEAATGGGST(ph)GEADGK ddPTM_A459_Selumetinib_30min_R1 1 EEAATGGGSTGEADGK 16 0 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 EEAAT(0.095)GGGS(0.25)T(0.655)GEADGK 197.73 2.4039e-06 7136700.0 3166.8 4023.0 2152.6 2061.2 2680.8 2401.2 3773.6 3341.7 1740.8 3302.6 True False 3240.580278479865 3551.985289758041 1860.288743385419 1701.2501135159805 2438.322113333682 2377.046108115161 3488.954313857208 3253.067260628614 2954.0104569984587 3726.5208800482023 0.8695993884885862 0.9531639306720042 0.4992025546791935 0.4565250452840546 0.6543159670427346 0.6378727463575662 0.9362497691981478 0.8729502303463641 0.7926992903257928 1.0 11.863613627900573 -7.259410829644289 24.80880438497977 0.8898873474382963 0.6716021038263278 0.3484071011124411 0.14829122660531355 219.12564207145869 2679892.8675807826 0.06549263912593732 0.04812736897641592 5.5028689510067425e-08 7.259410829644289 -0.21828524361196855 EEAENTLQS(ph)FR ddPTM_A459_Selumetinib_30min_R2 1 EEAENTLQSFR 11 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 EEAENTLQS(1)FR 130.15 0.0034529000000000005 0.0 5166.4 6490.3 6938.0 6514.8 7581.9 7260.0 9096.6 7723.7 5920.9 7301.6 True False 4879.272170737846 6988.085140396252 6491.616633523239 5627.473001343151 6629.393938953998 8259.999100281719 9519.609924570943 7746.1746882726275 7105.245443768517 7090.78383616488 0.6881146405637502 0.9855165947599704 0.9155005685569303 0.7936320061883066 0.934931044596555 1.1648922447971874 1.3425328066014937 1.0924285477107736 1.002039493508444 1.0 12.79172940070835 -6.65349091346079 4.270421764772701 1.1397202038307155 0.8612486606806808 0.5517621547022808 0.11670597357990387 0.17005769965500558 5.526405484541129 0.04075308604770975 0.04039218635900559 2.2207981476799498e-07 6.65349091346079 -0.27847154315003464 EEAENTLQS(ph)FRQDVDNASLAR ddPTM_A459_Selumetinib_30min_R1 2 EEAENTLQSFRQDVDNASLAR 21 1 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 EEAENT(0.074)LQS(0.926)FRQDVDNASLAR;EEAENT(0.107)LQS(0.893)FRQDVDNASLAR 98.804 0.00017546 36308000.0 1284.03 1654.9499999999998 2162.35 2061.11 1947.07 1641.63 1307.03 1339.53 791.27 1150.24 True False 1313.9454007125498 1461.1876846346186 1868.7147469383335 1701.175830326472 1770.9578622831275 1625.1166926807812 1208.4396748041092 1304.0013129933407 1342.7273979257645 1297.8845082863943 1.0123746699522294 1.1258225792091736 1.4398158965666445 1.3107297448002873 1.3644957243702178 1.2521273520911609 0.931084135058843 1.0047129037043692 1.0345507549809472 1.0 10.341946296091944 -7.251267133949698 23.26350143036324 0.9929796932437681 1.2616801238387096 0.548656844685111 0.11452387464881274 220.43717334630597 504131.5816494672 0.04811367014679265 0.03676642957593872 5.6070298229306835e-08 7.251267133949698 0.26870043059494153 EEAENTLQSFR ddPTM_A459_Selumetinib_30min_R1 2 EEAENTLQSFR 11 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ; 195.83 0.00026623 85002000.0 2779.9 2707.1000000000004 2270.07 2721.5 2826.2 2361.9 2680.1 2692.0 1622.48 1919.3500000000001 False True 2844.6662612562127 2390.151473503354 1961.8069626019399 2246.2411138820794 2570.5707090061373 2338.1414304336167 2477.937899239111 2620.5994151516375 2753.230058749345 2165.717268552206 1.3134984434777528 1.1036304268383026 0.9058462944765725 1.0371811438635774 1.1869373469624585 1.0796152685233364 1.1441650003075547 1.2100376412030565 1.2712786192030943 1.0 11.080629198023118 -7.4797059223391065 4.332362532066853 1.1805382693595048 1.0964854393785461 0.03524612146030026 0.11714601131952652 0.5684611537761053 23.38860077898436 0.055259649629878546 0.03446547772295291 3.313554191572321e-08 7.4797059223391065 -0.08405282998095864 EEAENTLQSFR ddPTM_A459_Selumetinib_30min_R2 4 EEAENTLQSFR 11 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ;;; 212.28 0.00027047 160463000.0 302219.0 268948.0 287531.0 325273.0 316289.0 247050.0 298778.0 266271.0 230073.0 281950.0 False True 285422.8778585132 289575.4467958792 269031.5685000823 280970.25627277704 276553.94816046377 281078.89500338846 312671.76901737566 267045.8045264629 276094.0287767331 273809.3709059226 1.0424145708167922 1.0575804832310638 0.9825506249474496 1.0261528133356503 1.0100236790488963 1.0265495810951026 1.1419323158402992 0.9752982655155964 1.0083439725355325 1.0 18.062812296957226 EEAGGGIS(ph)EEEAAQYDR ddPTM_A459_Selumetinib_30min_R2 2 EEAGGGISEEEAAQYDR 17 0 A0A590UK93;A0A590UKC5;M0QZS6;B3KNJ4;Q9UBE0-2;Q9UBE0-3;Q9UBE0;M0R375 A0A590UK93 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 EEAGGGIS(0.996)EEEAAQY(0.004)DR;EEAGGGIS(1)EEEAAQYDR 135.08 0.00051742 13388800.0 28271.5 27115.6 29574.0 35853.0 39190.0 31141.0 28288.0 34516.0 31716.0 29369.0 True False 26700.283209781468 29195.27932960398 27671.24103773659 30969.759550125265 34266.60183695478 35430.390080147794 29603.448051608608 34616.43584556861 38060.08621908198 28521.04066017398 0.9361609040817725 1.0236400444662417 0.9702044665002694 1.085856575821604 1.2014499136002337 1.2422544640743718 1.0379511885394166 1.21371573562202 1.334456434201157 1.0 14.79973900256132 -5.975245174864226 3.037974578328057 1.1786033355898928 0.9810021864650896 0.46735737788624643 0.09283168441732105 0.2238378534083469 4.244720207299615 0.02763428660146499 0.04160961718245308 1.058655907090275e-06 5.975245174864226 -0.1976011491248032 EEAIEHNYGGHDDDLSVR ddPTM_A459_Selumetinib_30min_R2 1 EEAIEHNYGGHDDDLSVR 18 0 Q93009;H3BND8;A0A669KBL1;Q93009-3;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 87.088 0.003954699999999999 5905600.0 35928.0 26058.0 33862.0 38244.0 35722.0 22890.0 25472.0 36200.0 30912.0 31961.0 False True 33931.265591179406 28056.564810323966 31683.355786157983 33035.101225420185 31234.28300126813 26042.889725268393 26656.49847181048 36305.33600676741 37095.263753445026 31038.202885349223 1.0932097362890743 0.9039365105628373 1.020785768531505 1.0643367899696778 1.0063173797994427 0.8390592013805432 0.8588286689882095 1.1696983920388122 1.19514856869999 1.0 14.921757407324117 -7.778740734723935 24.999375348543733 1.1368176799964569 0.9689945220489018 0.36028375023600023 0.09222250413793236 263.3895854695664 380576.12917621125 0.052048092141930374 0.025096542378355843 1.6644059715197886e-08 7.778740734723935 -0.1678231579475551 EEAPAS(ph)PLRPLYPQIS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 2 EEAPASPLRPLYPQISPLK 19 1 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 2 EEAPAS(1)PLRPLYPQIS(1)PLK;EEAPAS(1)PLRPLY(0.009)PQIS(0.991)PLK 84.947 0.0077054 38045000.0 14310.2 17312.3 11874.8 11595.9 12342.400000000001 12690.5 14771.4 15128.2 9071.8 15432.3 True False 14643.599817197983 15285.367867730078 10262.267383607345 9570.893747001726 11226.032099227708 12562.845092052075 13657.181405477628 14726.950992680915 15394.182021943137 17413.186028331576 0.8409489104045965 0.8778042021064095 0.5893388703773362 0.5496348417474956 0.6446857043256039 0.7214558594625988 0.7843011257823319 0.8457355804227839 0.8840531535640014 1.0 14.087892571438456 -8.032003377590543 1.0629996902505603 0.982120520857241 0.6968701001359765 0.5046668166791219 0.09640233802758935 0.47015267711564274 0.988495513863491 0.10130242121103698 0.03622591692839406 9.289591620602758e-09 8.032003377590543 -0.2852504207212645 EEAPAS(ph)PLRPLYPQIS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 EEAPASPLRPLYPQISPLK 19 1 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 2 EEAPAS(1)PLRPLY(0.001)PQIS(0.999)PLK;EEAPAS(0.994)PLRPLY(0.008)PQIS(0.998)PLK 87.881 0.0064271 37735000.0 579260.0 419720.0 481960.0 526520.0 524510.0 481300.0 551910.0 580090.0 446490.0 452540.0 True False 547067.0481615067 451911.1743874874 450951.21831837244 454807.0677023393 458616.36462110595 547594.7061936076 577574.9085889182 581777.9658609309 535800.4759729437 439473.99435987347 1.244822344854217 1.0283001501504763 1.0261158205167893 1.0348896033422856 1.0435574584774119 1.2460230030020776 1.314241379470471 1.3238052156153943 1.2191858513798455 1.0 18.745418271618725 -6.766363736726529 24.88675110703737 1.24673834569705 1.067908975430684 0.3110321995056414 0.10413096299093083 114.78774880169762 580110.6607683199 0.035012712845100526 0.03185009319620409 1.7125224096511927e-07 6.766363736726529 -0.17882937026636592 EEAPAS(ph)PLRPLYPQISPLK ddPTM_A459_Selumetinib_30min_R2 4 EEAPASPLRPLYPQISPLK 19 1 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 1 EEAPAS(1)PLRPLYPQISPLK;EEAPAS(0.998)PLRPLY(0.001)PQIS(0.001)PLK;EEAPAS(0.999)PLRPLY(0.001)PQISPLK;EEAPAS(0.979)PLRPLY(0.02)PQIS(0.002)PLK 87.32600000000002 0.0018589 170179900.0 223726.6 175808.8 210721.1 251037.7 212526.6 196291.5 239019.8 226435.8 198382.9 181613.1 True False 211292.77122053975 189292.76964560887 197163.5338417868 216845.9321958126 185827.10849608967 223328.87236817513 250134.69430874876 227094.69068953505 238065.02328135743 176369.4579154977 1.1980122506345432 1.0732740911201473 1.1179006624619323 1.2294982065415658 1.053624083740867 1.2662559323348188 1.4182426893243245 1.2876078056459235 1.3498086692278624 1.0 17.428241223944262 -6.893501607042004 6.877313483048764 1.2952669847693106 1.1359796366557084 0.22822432597793252 0.11360768639388431 0.2598604892396729 15.004929020702889 0.03778739273362629 0.033326046257363094 1.2779044808624637e-07 6.893501607042004 -0.15928734811360212 EEAPASPLRPLYPQIS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 4 EEAPASPLRPLYPQISPLK 19 1 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 1 EEAPAS(0.003)PLRPLYPQIS(0.997)PLK;EEAPASPLRPLYPQIS(1)PLK;EEAPAS(0.016)PLRPLY(0.009)PQIS(0.975)PLK;EEAPAS(0.004)PLRPLY(0.003)PQIS(0.992)PLK 84.573 0.0021933000000000005 48649500.0 84257.5 57659.5 68091.9 72144.9 72064.4 64059.7 74934.2 78508.4 57805.7 58871.2 True False 79574.80545949677 62081.798245486 63710.9412868551 62318.64016310571 63011.02580808983 72883.34219894175 78418.78877930038 78736.8464462348 69368.45522620712 57171.435490252785 1.3918629955174653 1.085888393620454 1.114384145518215 1.0900310553463446 1.1021417473212238 1.2748209236650654 1.371642816151959 1.377206043036277 1.2133411489734909 1.0 15.803006894216239 -6.775897885321365 23.240041105136996 1.2787427169661032 1.1468460522079806 0.08133284404660113 0.1305162996497638 172.0000382789024 276462.65782230475 0.04470860236863451 0.03964706923930102 1.675336747857429e-07 6.775897885321365 -0.13189666475812256 EEAQWT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 EEAQWTPTK 9 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 EEAQWT(0.907)PT(0.093)K 115.0 0.019421 13401000.0 5409.0 5584.8 5070.9 6010.1 5465.4 4715.7 5392.8 4790.6 2925.3 4847.1 True False 5535.019175918151 4930.929019696916 4382.29963245987 4960.548858549584 4971.05553499474 4668.264339513018 4986.0167542318095 4663.537725938126 4964.0204445413565 5469.272499752206 1.012021100826284 0.9015694536924826 0.8012582354706986 0.9069851353675153 0.9089061726618962 0.853543929238216 0.9116416771074596 0.8526797167538122 0.9076198790179606 1.0 12.417133229050888 -8.557327389036235 21.101486535287236 1.0000000014949115 0.890313139401001 0.2720939153923725 0.051688606864436576 2219.3659218792986 1359469.9073717028 0.04970112929500336 0.012832776391498185 2.7712302497416833e-09 8.557327389036235 -0.10968686209391054 EEAS(ph)DDDMEGDEAVVR ddPTM_A459_Selumetinib_30min_R1 5 EEASDDDMEGDEAVVR 16 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR 271.43 1.4531999999999995e-50 169559000.0 14234.35 15709.03 11238.28 10182.720000000001 13344.73 11158.929999999998 15791.900000000001 17246.19 8399.490000000002 14060.57 True False 14565.98265977639 13869.809464670088 9712.183303453254 8404.499105327695 12137.701527703433 11046.681295697776 14600.704268868374 16788.765017679798 14253.32105552274 15865.381121049882 0.9180985031901013 0.874218486076448 0.6121619915305606 0.5297382421010213 0.7650431738824959 0.6962758229010491 0.9202870172148868 1.058201179636636 0.8983913431875713 1.0 13.953594557902031 -7.37121064770892 4.053792069603896 0.9845241919076926 0.7258524081383677 0.5186606613538556 0.11254690387450308 0.20872738159193824 5.944000524270315 0.05477831335652498 0.035725391245118185 4.2539203337090456e-08 7.37121064770892 -0.25867178376932487 EEAS(ph)DDDMEGDEAVVR ddPTM_A459_Selumetinib_30min_R2 8 EEASDDDMEGDEAVVR 16 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR;EEAS(1)DDDMEGDEAVVR 268.08 2.3795999999999997e-50 1053173900.0 156623.7 99794.1 153234.5 179812.8 169519.40000000002 146197.1 150256.8 169641.40000000002 144668.3 134261.1 True False 147919.1817683481 107447.98658139321 143375.55909910917 155321.9864456186 148222.85744933592 166334.4234798618 157244.03892820064 170135.02838835426 173606.00237003498 130384.63319076895 1.134483245060972 0.824084740294383 1.0996354063391265 1.1912599103482018 1.1368123207622745 1.275721067807844 1.2060013138061525 1.3048702460160742 1.3314912817680578 1.0 16.99241432156831 -5.60232757771973 3.152956606561619 1.2203551739815652 0.9748456730785008 0.3836866639537049 0.11355895842721807 0.21552363779728473 4.2807839344453384 0.03059128311579082 0.05983722935187763 2.4984601233469233e-06 5.60232757771973 -0.24550950090306445 EEAS(ph)PVPLTSNVGSTVK ddPTM_A459_Selumetinib_30min_R2 2 EEASPVPLTSNVGSTVK 17 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 EEAS(1)PVPLTSNVGSTVK;EEAS(1)PVPLTSNVGSTVK 194.94 5.8718e-08 8027800.0 43088.0 25972.0 32728.0 41098.0 41945.0 40510.0 56772.0 58463.0 51273.0 36571.0 True False 40693.3414549304 27963.96888685753 30622.31611155214 35500.381501995595 36675.49410694225 46089.884786833696 59412.010491583846 58633.11765092932 61529.03268731838 35515.10020713077 1.145803931781106 0.787382514022666 0.8622336958915225 0.9995855648710174 1.0326732542789925 1.297754603479331 1.6728661933960989 1.6509348786564 1.7324752662520857 1.0 15.116144935492043 -6.88463222129934 2.2933950720349796 1.5674464051953365 0.9383710115168966 0.5956133458420181 0.21207226559549672 0.18236997625808063 1.9553001234765475 0.0820905008221946 0.07000586020747689 1.304270821901343e-07 6.88463222129934 -0.6290753936784399 EEAS(ph)SPLK ddPTM_A459_Selumetinib_30min_R1 4 EEASSPLK 8 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 EEAS(0.871)S(0.129)PLK;EEAS(0.5)S(0.5)PLK;EEAS(0.5)S(0.5)PLK;EEAS(0.5)S(0.5)PLK 133.99 0.0029199 72022100.0 34821.100000000006 41576.1 25329.9 27051.1 27638.5 30415.899999999998 33638.6 32055.0 18338.8 32749.6 True False 35632.36387993408 36708.3508837955 21890.238707181215 22327.133197036746 25138.602554973488 30109.943661427576 31101.21331940775 31204.797270685634 31119.604187042343 36953.330168118 0.964253119213499 0.9933705762590821 0.5923752638149868 0.6041981357420336 0.6802797593777398 0.8148100191361196 0.8416349264846705 0.8444380284191005 0.842132604706117 1.0 15.173416762880008 -8.588819168739311 0.7966226265061357 0.9956339181671754 0.7703149245884711 0.20652576599898553 0.12682253938147167 1.3317412908226771 1.8652101599498883 0.1389471778818308 0.05073181170359864 2.5773941073321893e-09 8.588819168739311 -0.22531899357870433 EEAS(ph)SPLK ddPTM_A459_Selumetinib_30min_R2 2 EEASSPLK 8 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 EEAS(0.605)S(0.395)PLK;EEAS(0.8)S(0.2)PLK 115.78 0.0096739 48129000.0 636100.0 464540.0 511020.0 502750.0 551930.0 445530.0 631710.0 616090.0 479650.0 544910.0 True False 600748.1085100548 500168.7242684728 478141.52955650666 434274.58270787686 482591.6190831953 506897.71338133817 661085.7667096172 617882.7199008102 575593.4025407564 529177.0324537922 1.135249777800045 0.9451822237053488 0.903556844369012 0.820660300947203 0.9119662976403559 0.9578981745123274 1.2492714652489068 1.1676295114995638 1.0877142567426474 1.0 19.013390921004124 -7.14808458887177 6.700064650601418 1.139452970645582 0.9347394584632941 0.4613713106477717 0.09484391330633997 0.2100563816025181 11.002305057423273 0.03744586115164976 0.02895322807649154 7.110750018997898e-08 7.14808458887177 -0.20471351218228795 EEASDYLELDTIK ddPTM_A459_Selumetinib_30min_R2 2 EEASDYLELDTIK 13 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 ; 212.09 6.896e-05 5154700.0 31874.0 26399.0 31980.0 34161.0 33284.0 27629.0 32283.0 30716.0 25811.0 30518.0 False True 30102.570681731606 28423.71841383614 29922.441617191296 29508.212868988066 29102.56635726468 31434.6439589096 33784.223467550924 30805.37847469246 30973.921219596585 29636.866044713486 1.0157136937595057 0.9590662646635087 1.0096358222238127 0.9956590155136066 0.9819717885608181 1.0606601896261159 1.1399391358242896 1.0394276651322047 1.0451145938597513 1.0 14.85510527723379 -6.768842183671655 22.352077468190377 1.0646745468804244 0.9916944841031278 0.4391127423646489 0.035996292608917645 39.10432037451033 118069.31565749997 0.012455111359408072 0.011235724913391197 1.7027771605561024e-07 6.768842183671655 -0.07298006277729663 EEASLLSHS(ph)PGTS(ph)NQSQPCSPKPIR ddPTM_A459_Selumetinib_30min_R2 1 EEASLLSHSPGTSNQSQPCSPKPIR 25 1 Q9H4Z3 Q9H4Z3 PCIF1 Phosphorylated CTD-interacting factor 1 2 EEAS(0.001)LLS(0.053)HS(0.906)PGT(0.094)S(0.594)NQS(0.276)QPCS(0.076)PKPIR 86.959 0.00016312 7795800.0 19718.0 19749.0 25848.0 31982.0 36082.0 22522.0 25017.0 25254.0 21399.0 32781.0 True False 18622.15249740803 21263.684796956313 24184.967821174505 27625.996427972717 31549.056582827292 25624.201065639798 26180.340070245074 25327.48495897523 25679.397938016613 31834.527354733327 0.5849671424331415 0.6679441023268314 0.7597087134883614 0.8677997986316934 0.991032668123983 0.8049185332676175 0.8223882132288809 0.7955979580519641 0.8066524013964499 1.0 14.958304724325801 -5.32005914276396 1.8893902291950615 0.8610393260017396 0.5962112554859503 0.6565404990008643 0.07080357592391578 0.2531565001950029 1.6364786930443869 0.021036500941120716 0.07885055107800758 4.785649163179555e-06 5.32005914276396 -0.26482807051578927 EEASLLSHS(ph)PGTSNQSQPCS(ph)PKPIR ddPTM_A459_Selumetinib_30min_R2 1 EEASLLSHSPGTSNQSQPCSPKPIR 25 1 Q9H4Z3 Q9H4Z3 PCIF1 Phosphorylated CTD-interacting factor 1 2 EEAS(0.001)LLS(0.024)HS(0.864)PGT(0.152)S(0.104)NQS(0.23)QPCS(0.626)PKPIR 80.632 0.00037532 7219500.0 31942.0 22951.0 32271.0 37945.0 40321.0 31421.0 26009.0 29457.0 27326.0 35189.0 True False 30166.791513957174 24711.267900903567 30194.71899400813 32776.825541223974 35255.51550568647 35748.95753856087 27218.470035855782 29542.71499313115 32791.96355223337 34173.00213799796 0.8827667932754973 0.723122534014253 0.8835840313963443 0.9591438706164614 1.0316774441799725 1.04611697252114 0.7964904554168734 0.8645045253510737 0.9595868522119404 1.0 15.060569375322103 -5.509861361890847 5.1830176027221695 0.9451587024691525 0.8016539584295939 0.35805548524227016 0.07907432522319226 0.20204788318865444 16.33746651128102 0.022863096530505545 0.04497441939460977 3.0912820927730707e-06 5.509861361890847 -0.1435047440395586 EEASLLSHS(ph)PGTSNQSQPCSPKPIR ddPTM_A459_Selumetinib_30min_R2 2 EEASLLSHSPGTSNQSQPCSPKPIR 25 1 Q9H4Z3 Q9H4Z3 PCIF1 Phosphorylated CTD-interacting factor 1 1 EEASLLS(0.037)HS(0.962)PGT(0.002)SNQSQPCSPKPIR;EEAS(0.001)LLS(0.005)HS(0.829)PGT(0.122)S(0.034)NQS(0.003)QPCS(0.007)PKPIR 136.53 2.1802e-08 54934000.0 39563.0 34092.0 46745.0 63607.0 69463.0 44958.0 37863.0 44848.0 36504.0 55068.0 True False 37364.24684323732 36706.74677694236 43737.477592107825 54943.61687180481 60736.43693290092 51150.55641190989 39623.70452411116 44978.50025501394 43805.820006979724 53478.043756153165 0.698683875079821 0.6863891084781667 0.8178585924260815 1.0274051370004165 1.1357266023013903 0.9564777022350323 0.7409340682839034 0.8410648014745066 0.8191365452095364 1.0 15.706659071702562 -5.4775015617811915 4.01202933054216 0.9268319236256678 0.6976775839787858 0.44352083675177933 0.1069564696126489 0.2352715553101332 7.9143990195083855 0.03334529152360092 0.07049254914426432 3.330415646444688e-06 5.4775015617811915 -0.22915433964688203 EEATYGVWAERDS(ph)DDERPSFGGK ddPTM_A459_Selumetinib_30min_R1 2 EEATYGVWAERDSDDERPSFGGK 23 2 Q9UBB9;F6XM96;F6UKU9;F6SQZ1 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 EEAT(0.001)Y(0.004)GVWAERDS(0.866)DDERPS(0.129)FGGK;EEATYGVWAERDS(1)DDERPSFGGK 94.188 3.4634e-05 52708000.0 4906.4 5095.1 4741.0 5208.6 4947.6 4768.4 5463.0 4920.8 2343.42 4139.7 True False 5020.709573807506 4498.563323352273 4097.198240448884 4299.015787531213 4500.090453569725 4720.434225360794 5050.9215117134645 4790.284398988924 3976.6125833750725 4671.070819092696 1.0748519489975799 0.9630689616104063 0.8771432502589885 0.9203490921095154 0.9633958952572287 1.0105678993489733 1.0813198316472004 1.025521681111952 0.8513278298245723 1.0 12.189537602970674 -6.655563701734414 5.277863047574473 1.0006323612051777 0.9521207319032629 0.045692283174899484 0.07166682616110717 0.58092886763413 24.903503667215748 0.025216876201438285 0.025074828246477554 2.210224039812735e-07 6.655563701734414 -0.04851162930191488 EEATYGVWAERDS(ph)DDERPSFGGK ddPTM_A459_Selumetinib_30min_R2 3 EEATYGVWAERDSDDERPSFGGK 23 2 Q9UBB9;F6XM96;F6UKU9;F6SQZ1 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 EEAT(0.003)Y(0.003)GVWAERDS(0.993)DDERPS(0.001)FGGK;EEAT(0.001)Y(0.001)GVWAERDS(0.994)DDERPS(0.004)FGGK;EEAT(0.01)Y(0.009)GVWAERDS(0.98)DDERPS(0.001)FGGK 56.529 0.006833199999999999 50896000.0 144884.0 132201.0 169005.0 175295.0 160932.0 130343.0 121441.0 133258.0 114244.0 165602.0 True False 136831.92729660528 142340.39160678597 158131.40229873123 151419.51859925824 140714.28340966586 148296.5651140524 127088.24713077622 133645.75871795058 137095.99224406577 160820.63997433145 0.8508356098971189 0.8850878321930872 0.983278031501246 0.9415428182814487 0.8749765168956251 0.9221239583284956 0.7902483608513232 0.8310236717083189 0.8524775940821254 1.0 17.29509305059112 -7.20217624427459 24.997475776508537 0.8543555738301566 0.9117463695850005 0.07936452310055586 0.06144515471145002 462.2955301511703 194998.43987650156 0.02314524605679411 0.01792822771608419 6.278035334881311e-08 7.20217624427459 0.05739079575484396 EECPRPMSIS(ph)PPDFSPK ddPTM_A459_Selumetinib_30min_R2 1 EECPRPMSISPPDFSPK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EECPRPMS(0.154)IS(0.825)PPDFS(0.021)PK 67.563 0.021213 8470800.0 48781.0 38222.0 43963.0 46085.0 41459.0 36706.0 42218.0 48149.0 30681.0 37235.0 True False 46069.947305815076 41153.50449689931 41134.46844329524 39808.14349894074 36250.54977183742 41761.91831610757 44181.22065337994 48289.105618503934 36818.05729876575 36159.928801851565 1.2740607858568591 1.1380969448919946 1.1375705043199353 1.1008910918237862 1.0025061158301067 1.1549225814285662 1.2218281981550154 1.3354314352530279 1.0182004920562922 1.0 15.14210421666879 -4.761113121839171 6.116898480585962 1.133485486323282 1.278970581264029 0.16573363961603937 0.09919166772013141 0.2703301769507687 40.79122647438612 0.025380750783850832 0.16469114396216694 1.7333524480246747e-05 4.761113121839171 0.14548509494074713 EECPRPMSISPPDFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 EECPRPMSISPPDFSPK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EECPRPMSISPPDFS(1)PK;EECPRPMSIS(0.001)PPDFS(0.999)PK;EECPRPMSIS(0.018)PPDFS(0.982)PK;EECPRPMS(0.001)IS(0.002)PPDFS(0.997)PK 94.454 0.0037339 74972000.0 12790.4 13557.900000000001 11358.800000000001 11263.7 10065.9 11442.699999999999 11589.9 11373.9 8992.4 13664.5 True False 13088.391434213989 11970.534765103286 9816.337349422227 9296.706240835412 9155.44112227899 11327.596827140322 10715.66451191798 11072.227224365985 15259.4460210897 15418.471678501379 0.8488773535488399 0.7763762203353983 0.6366608542083686 0.6029589984458835 0.5937969283327091 0.7346770200923912 0.6949887599339226 0.7181144444948104 0.9896860298006439 1.0 13.91237214797222 -8.252244596751467 4.379355957746542 1.0037934219550244 0.6935699186076801 0.7190931771720278 0.07356243816581667 0.11049456773457159 5.346607929957751 0.0682016689081209 0.020867584638548476 5.594424320690381e-09 8.252244596751467 -0.3102235033473443 EECPRPMSISPPDFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 EECPRPMSISPPDFSPK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EECPRPMSISPPDFS(1)PK;EECPRPMSISPPDFS(1)PK;EECPRPMSISPPDFS(1)PK;EECPRPMSISPPDFS(1)PK 138.28 0.00028010000000000003 96869000.0 187961.0 159723.0 171455.0 166976.0 152162.0 120099.0 167812.0 148614.0 116553.0 132225.0 True False 177514.88008749933 171973.2405096084 160423.77196608897 144233.58075033367 133046.0492144607 136641.54709982558 175615.59051316977 149046.442135628 139866.85676291623 128407.32068819205 1.3824358232546088 1.3392790970789452 1.249335093250965 1.123250450031366 1.0361251095452164 1.0641258330716865 1.3676446916886635 1.1607316571736073 1.0892436351238186 1.0 16.970367929385198 -5.472993965232132 2.338602006167685 1.1313813691892889 1.3672511556613733 0.5096615104227257 0.09516809961457001 0.2793212276915063 2.973416923430164 0.028812641982941277 0.07295088204047391 3.365162454268799e-06 5.472993965232132 0.23586978647208445 EEDEEPES(ph)PPEK ddPTM_A459_Selumetinib_30min_R1 2 EEDEEPESPPEK 12 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EEDEEPES(1)PPEK;EEDEEPES(1)PPEK 205.87 2.7153e-08 39638000.0 10512.3 12043.8 6430.6 6109.4 6703.7 7191.1 10367.7 10568.400000000001 5435.5 10096.5 True False 10757.216136624957 10633.706296989287 5557.35984075735 5042.5079776414395 6097.35151863436 7118.764062996388 9585.656041916842 10288.091700998726 9223.646506787178 11392.484123238264 0.9442379748138078 0.9333966307926442 0.48780931187970744 0.44261707307151626 0.5352082524475105 0.6248649535947661 0.8414017468204433 0.9030595601193939 0.8096255748097015 1.0 13.475794739547391 -7.35119828207406 4.2290130212359545 0.8881991206180876 0.6501898818664743 0.3164597802492508 0.16414408047774173 0.3338638797128633 10.711887748156004 0.08161076064391133 0.053761100504271686 4.454528254210852e-08 7.35119828207406 -0.23800923875161328 EEDEEPES(ph)PPEK ddPTM_A459_Selumetinib_30min_R2 3 EEDEEPESPPEK 12 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EEDEEPES(1)PPEK;EEDEEPES(1)PPEK;EEDEEPES(1)PPEK 179.93 0.00010393 187792900.0 433728.0 298861.0 355944.0 422588.0 410022.0 376957.0 523273.0 533015.0 446478.0 318095.0 True False 409623.13411075104 321782.67771042394 333042.9505625248 365030.7853950387 358511.37071681255 428879.4050750545 547606.2313457784 534565.9854046169 535786.0756376358 308910.7708399355 1.3260241233964627 1.0416686891023237 1.0781202275886117 1.181670630656586 1.1605661069764963 1.388360153027107 1.7727003492200173 1.7304867161190904 1.7344363687314013 1.0 18.236830648951916 -6.955435504811657 3.302656262914474 1.6193714150468075 1.1480841465259004 0.4145156870683695 0.2202108206913426 0.19917635334340753 4.481079792983693 0.08036616851002017 0.06745591762113463 1.1080631067984842e-07 6.955435504811657 -0.4712872685209071 EEDEEPES(ph)PPEKK ddPTM_A459_Selumetinib_30min_R1 6 EEDEEPESPPEKK 13 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK 254.45 3.8376999999999996e-23 1486920000.0 33188.0 38664.0 23691.399999999998 22984.8 23064.4 27269.000000000004 34591.0 33965.9 19809.140000000003 38008.9 True False 33961.21582739351 34137.20090559404 20474.23800754496 18970.936158132215 20978.22909235055 26994.698618271 31981.77302062613 33065.01399520768 33614.66377765765 42887.71255303827 0.7918635386626051 0.7959669302338598 0.47739170006385695 0.4423396592828607 0.48914310984544224 0.6294273350411791 0.7457094612139781 0.7709670678825997 0.7837830878969625 1.0 15.38827675039835 -8.218668836349165 0.8595075510765208 0.9802892871319412 0.5981114014771116 0.5060264311968694 0.11899255898381653 0.5276144848164771 0.8188064277744247 0.1285107300240551 0.04824341895653102 6.044093354553583e-09 8.218668836349165 -0.3821778856548296 EEDEEPES(ph)PPEKK ddPTM_A459_Selumetinib_30min_R2 5 EEDEEPESPPEKK 13 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK;EEDEEPES(1)PPEKK 230.86 3.898999999999999e-51 588859200.0 540079.0 418349.0 436951.0 472493.0 435477.0 388726.0 592798.0 568804.0 441292.0 394665.0 True False 510063.5712875357 450435.02309594874 408838.0483762772 408138.6383041122 380768.48604622524 442269.47799670923 620364.2816069529 570459.1254694283 529562.7307286898 383269.9959871823 1.3308205093742682 1.1752420690687528 1.066710289500329 1.0648854399700036 0.9934732434911479 1.153937126900745 1.6186090434997153 1.4884001655284962 1.3816962879254446 1.0 18.548001536663982 -7.115096505710068 7.768778149243579 1.412038147475663 1.1175813912969632 0.31623806828183754 0.16995754329748694 0.28237182218560936 17.31652528773404 0.06385938211491013 0.049454037024541556 7.671909909070764e-08 7.115096505710068 -0.2944567561786997 EEDEHPY(ph)ELLLTAETK ddPTM_A459_Selumetinib_30min_R1 5 EEDEHPYELLLTAETK 16 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 EEDEHPY(1)ELLLTAETK;EEDEHPY(1)ELLLTAETK;EEDEHPY(1)ELLLTAETK;EEDEHPY(1)ELLLTAETK;EEDEHPY(1)ELLLTAETK 209.56 3.4878e-07 20243400.0 29570.47 29404.13 30622.480000000003 34076.72 21736.3 26660.899999999998 21349.769999999997 18819.88 14144.59 16367.99 True False 30259.40441688156 25961.48078999081 26464.115413242173 28125.860551257665 19770.25550285545 26392.715552160385 19739.33966010156 18320.71564681428 24002.336150020583 18468.98095422399 1.6383905799611005 1.4056801972094313 1.4328952679541118 1.5228701908875528 1.0704573009120921 1.4290293339722233 1.0687833675840697 0.9919721988031072 1.2996026261281663 1.0 14.172816645824001 -5.714146585680222 0.3413179337390476 1.0220528108813294 1.7843212497563958 0.5979542593702349 0.14160102968630692 2.4858928113413366 0.3742283655032831 0.14881375004592876 0.743945319175846 1.9313163375108556e-06 5.714146585680222 0.7622684388750665 EEDEHPY(ph)ELLLTAETK ddPTM_A459_Selumetinib_30min_R2 1 EEDEHPYELLLTAETK 16 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 EEDEHPY(1)ELLLTAETK 118.47 0.011488 1108200.0 13048.0 17354.0 11085.0 14538.0 10915.0 15993.0 15546.0 13702.0 11753.0 15957.0 True False 12322.844395282475 18684.995998095103 10371.803168435441 12557.89932055116 9543.760118661936 18195.890580000763 16268.91980381459 13741.870551511787 14103.92840625773 15496.279948734946 0.7952130728180644 1.2057730022888797 0.6693092279403583 0.8103815471903847 0.6158742711305399 1.1742102388571138 1.0498596990784694 0.8867851250088973 0.9101493037630053 1.0 13.919634301910135 -6.770277439712907 24.999582443477763 0.9999785659840478 0.8319509392529069 0.2395843621989665 0.16383720746670774 338.6765713718414 957984.1466687375 0.059697190564579325 0.05342608791331463 1.6971591123910076e-07 6.770277439712907 -0.1680276267311409 EEDEPEERS(ph)GDETPGSEVPGDK ddPTM_A459_Selumetinib_30min_R1 4 EEDEPEERSGDETPGSEVPGDK 22 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 EEDEPEERS(1)GDETPGSEVPGDK;EEDEPEERS(0.967)GDET(0.033)PGSEVPGDK;EEDEPEERS(1)GDETPGSEVPGDK;EEDEPEERS(1)GDETPGSEVPGDK 125.91 1.6796e-05 456249000.0 17688.7 17113.3 15015.0 13436.0 15829.800000000003 14998.8 18037.0 18974.399999999998 10040.0 15896.300000000001 True False 18100.812293781353 15109.666880242672 12976.045471491247 11089.65482495668 14397.997384978182 14847.92568982079 16676.454568327994 18471.137274462566 17037.146707412976 17936.744948074316 1.0091469966363462 0.8423862258165655 0.7234336837066053 0.6182646214271593 0.8027096012492471 0.8277937682006712 0.9297369515263344 1.0297931607956339 0.9498460705515066 1.0 14.130630481994451 -7.3067178575778655 2.310971892693283 0.992438618588203 0.7888827010771695 0.45698266305084934 0.09424054693404406 0.30059581776256333 3.1437230041729243 0.05082359181291358 0.03215427146815719 4.934943018325497e-08 7.3067178575778655 -0.20355591751103352 EEDEPEERS(ph)GDETPGSEVPGDK ddPTM_A459_Selumetinib_30min_R2 3 EEDEPEERSGDETPGSEVPGDK 22 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 EEDEPEERS(1)GDETPGSEVPGDK;EEDEPEERS(1)GDETPGSEVPGDK;EEDEPEERS(0.954)GDET(0.002)PGS(0.044)EVPGDK 102.24 5.7883e-05 412811000.0 378046.0 348523.0 369461.0 370034.0 352982.0 269544.0 268757.0 292746.0 212226.0 319059.0 True False 357035.71675804385 375253.59342192626 345690.2814987216 319634.7308557463 308637.24546088214 306671.2393231867 281254.73303189257 293597.84239329083 254677.1300898882 309846.9376551626 1.1522970646732646 1.211093439430912 1.1156808071585658 1.0315891235674461 0.9960958394379009 0.9897507512709058 0.907721519406814 0.9475576702973394 0.8219449642369084 1.0 18.241196184067803 -5.968161486231727 0.797383804167719 0.9152936914186071 1.20865271585317 0.811946103222247 0.04793881196591485 0.3034339882511238 0.3795023652226701 0.02307864426005252 0.05873988162109522 1.076065019744642e-06 5.968161486231727 0.29335902443456285 EEDGADAS(ph)EEDLTR ddPTM_A459_Selumetinib_30min_R1 2 EEDGADASEEDLTR 14 0 Q86X53;E5RHA3 Q86X53 ERICH1 Glutamate-rich protein 1 1 EEDGADAS(1)EEDLTR;EEDGADAS(1)EEDLTR 214.89 8.3241e-07 62018000.0 8388.5 9418.7 9551.2 9309.599999999999 10175.900000000001 8802.0 9696.6 9206.099999999999 4695.7 7519.7 True False 8583.935728820368 8315.954225365169 8254.199500986157 7683.85312283542 9255.491641701059 8713.45987157656 8965.177655222556 8961.924322372766 7968.259939641347 8484.926743080745 1.011668808551631 0.9800855655173017 0.9728073972727295 0.9055886226833271 1.0908157397173395 1.0269340131524622 1.056600478316851 1.056217053338852 0.9391076883650495 1.0 13.050686488584374 -6.264090297332992 24.99623634127406 1.0324388209530275 0.9688102977276918 0.3007921370090404 0.0450857850589729 295.93570260998456 2790449.816553762 0.01370862084002726 0.01630136955358143 5.443894530933737e-07 6.264090297332992 -0.06362852322533574 EEDGADAS(ph)EEDLTR ddPTM_A459_Selumetinib_30min_R2 2 EEDGADASEEDLTR 14 0 Q86X53;E5RHA3 Q86X53 ERICH1 Glutamate-rich protein 1 1 EEDGADAS(1)EEDLTR;EEDGADAS(1)EEDLTR 257.81 1.1928999999999999e-35 121541000.0 80960.0 83667.0 95560.0 90581.0 91408.0 62430.0 72295.0 81543.0 60540.0 81668.0 True False 76460.56730855846 90083.98986819321 89411.7736378612 78243.71153905947 79924.50984211189 71029.16581688527 75656.86074982486 81780.27662982959 72649.69162893256 79310.03264105316 0.9640718174283068 1.1358460823727254 1.1273702791490101 0.9865550288345017 1.00774778651069 0.8955886594871798 0.9539380861465273 1.0311466772426692 0.9160214566766801 1.0 16.275215756525107 -5.878031480679689 5.805936170166123 0.9675672585507804 1.081196415818317 0.41177898567165605 0.05801626980528354 0.19294786089795973 9.040143307809874 0.016389626114482952 0.024654041658670692 1.3242455412034695e-06 5.878031480679689 0.11362915726753653 EEDGS(ph)LSLDGADSTGVVAK ddPTM_A459_Selumetinib_30min_R1 1 EEDGSLSLDGADSTGVVAK 19 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 EEDGS(0.986)LS(0.014)LDGADSTGVVAK 125.96 0.00037841 6825500.0 2240.9 2898.5 2330.1 2581.8 2589.6 2225.9 2927.9 2988.4 1478.2 2485.1 True False 2293.108609967642 2559.142272523908 2013.6852183231279 2130.937096388299 2355.3711372310136 2203.509466955495 2707.046145734185 2909.13792430875 2508.3974365436115 2804.0867919238726 0.8177737638407225 0.9126473117360575 0.7181251393939724 0.7599397787991689 0.8399779721564905 0.785820707583618 0.9653931374488204 1.0374635809017887 0.8945505694645814 1.0 11.453315288910883 -7.284789067575559 7.699434804041997 0.977971879131139 0.8060314584284529 0.6670363503658178 0.05835119450682262 0.13770288006283013 37.30427421248378 0.024541482642111315 0.016888857889528743 5.190520760462182e-08 7.284789067575559 -0.17194042070268611 EEDGSLS(ph)LDGADSTGVVAK ddPTM_A459_Selumetinib_30min_R2 1 EEDGSLSLDGADSTGVVAK 19 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 EEDGSLS(1)LDGADSTGVVAK 163.56 6.257100000000001e-07 10019000.0 36410.0 24432.0 31128.0 40303.0 31400.0 29938.0 45319.0 42290.0 38702.0 30593.0 True False 34386.4779607783 26305.855838738 29125.25836960384 34813.66187344708 27455.251280438362 34061.687749894525 47426.42329789487 42413.0568985136 46443.481424231 29709.700599840053 1.1574158361246973 0.8854298531328728 0.9803282356120626 1.1717944365159476 0.9241174002469137 1.1464837094345508 1.5963278774391352 1.4275827774158698 1.5632429976248579 1.0 14.85864644600509 -7.073348119727687 5.228820976234756 1.4298074556791325 1.0225171373746782 0.5032514829019319 0.17370811709432582 0.1602184294877318 8.011434197891534 0.06306340495414853 0.04911953471281876 8.446015620031473e-08 7.073348119727687 -0.4072903183044543 EEEEDGQEGS(ph)IHNLPLVTSQR ddPTM_A459_Selumetinib_30min_R2 1 EEEEDGQEGSIHNLPLVTSQR 21 0 O75717;O75717-2;H3BSQ1 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 1 EEEEDGQEGS(1)IHNLPLVTSQR 93.176 0.00035421 1004600.0 4986.6 2489.8 4776.7 5293.8 4359.2 4110.7 7011.3 6194.8 7465.2 4666.0 True False 4709.464734941421 2680.7596540311843 4469.372322477727 4572.775307685638 3811.5583242575444 4676.911611780726 7337.339342627381 6212.825842395656 8958.448595115742 4531.280456276066 1.039323162709684 0.5916119471965565 0.9863376071298803 1.0091574228984435 0.8411658384504389 1.0321390734715954 1.6192640057105212 1.3710971771324725 1.9770236429987051 1.0 12.145703071553331 -7.149397348405109 4.008633685581125 1.5225444524864806 0.8917743679574742 0.5509845421753155 0.25563510177655235 0.16529103152176228 4.612589092506995 0.09646959001317008 0.0732715098269375 7.08928851931503e-08 7.149397348405109 -0.6307700845290064 EEEEDGQEGS(ph)IHNLPLVTSQRPFYDGPMPTPR ddPTM_A459_Selumetinib_30min_R1 1 EEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPR 32 1 O75717;O75717-2;H3BSQ1 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 1 EEEEDGQEGS(0.895)IHNLPLVT(0.074)S(0.028)QRPFY(0.002)DGPMPTPR 43.81800000000001 0.010989 15285000.0 817.02 1065.9 719.51 518.16 1139.5 760.83 1011.3 1021.8 418.36 737.99 True False 836.0549763558228 941.1039324765343 621.8044939855257 427.67308306784446 1036.4324261950646 753.176740978368 935.0168267976991 994.6985447258329 709.926364194551 832.7182051313423 1.004007083313321 1.1301589501434002 0.7467165844986543 0.5135868057554822 1.2446376454944816 0.9044797343653266 1.1228490274812972 1.1945199931937862 0.8525409434066309 1.0 9.701684554705528 -6.301743407528796 24.99997776071188 1.0589464823153358 0.8614480588069049 0.21971470204670351 0.18803787732023325 882.5982766998044 547460.0446474768 0.06099607941102268 0.06916385328324955 4.991793284770784e-07 6.301743407528796 -0.19749842350843094 EEEEDGQEGS(ph)IHNLPLVTSQRPFYDGPMPTPR ddPTM_A459_Selumetinib_30min_R2 1 EEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPR 32 1 O75717;O75717-2;H3BSQ1 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 1 EEEEDGQEGS(0.992)IHNLPLVT(0.005)S(0.002)QRPFYDGPMPTPR 42.192 0.017993000000000002 10093000.0 2242.6 1450.0 6965.4 8972.5 10753.0 7446.5 7044.6 6720.4 6569.4 5916.7 True False 2117.9652698390933 1561.2103375151476 6517.2537473541015 7750.430021574173 9402.112006960311 8472.187782403284 7372.187858610085 6739.955251377891 7883.463564372469 5745.869497567213 0.3686065739460032 0.2717100237268111 1.1342502209828278 1.348869831599149 1.6363253657155181 1.4744831545496093 1.2830412980544459 1.1730087594630492 1.3720227317571878 1.0 12.488309510851236 -5.343094288036662 3.436967461785398 1.3463362876839369 0.3040745596515478 0.8534843230644064 0.16394311886852125 0.08117784703976474 1.8250918112642964 0.04595087434781607 0.11217435148521339 4.538430737957527e-06 5.343094288036662 -1.0422617280323891 down EEEEEEEEDQEGDRETTIR ddPTM_A459_Selumetinib_30min_R1 1 EEEEEEEEDQEGDRETTIR 19 1 A0A0B4J2E5;Q15269 A0A0B4J2E5 PWP2 Periodic tryptophan protein 2 homolog 0 146.86 0.00012408 5563400.0 857.22 710.13 531.35 767.78 667.86 575.27 823.07 669.34 491.37 596.74 False True 877.1915581402397 626.9876494695193 459.1955884966282 633.7016360155736 607.45218092026 569.4833061033685 760.9851672425417 651.586928877265 833.8190017551316 673.3373917398302 1.3027518876883886 0.9311641640002373 0.6819695358223268 0.9411353710480238 0.902151266767868 0.8457621885989219 1.1301691790444597 0.9676975270801992 1.2383375882343834 1.0 9.395185772500103 -7.267358858259958 24.864067958631537 1.0813592038393804 0.9214192532162961 0.1713724005056677 0.1599664391739156 825.5234309892479 3467496.439911267 0.06667312105812376 0.04631612008838894 5.403076812959158e-08 7.267358858259958 -0.1599399506230843 EEEEEEEEDQEGDRETTIR ddPTM_A459_Selumetinib_30min_R2 2 EEEEEEEEDQEGDRETTIR 19 1 A0A0B4J2E5;Q15269 A0A0B4J2E5 PWP2 Periodic tryptophan protein 2 homolog 0 ; 122.5 0.001184 8634000.0 18511.1 16704.3 17332.9 18604.9 14447.3 15231.400000000001 13220.4 16247.8 10125.2 13659.1 False True 17482.327167804542 17985.466097209846 16217.720084634615 16070.88052475736 12632.301013499273 17329.387093117228 13835.174795725616 16295.0784080319 12150.522921725595 13264.72629239615 1.3179561177848111 1.3558867104193326 1.2226200320417644 1.211550104427696 0.9523227796068882 1.306426285105566 1.0430049207767271 1.2284519144109942 0.9160025358902988 1.0 13.695307286501155 -1.5228787454986836 0.19678674959547154 0.989027363956016 2.763646601272671 0.46974215161573707 0.11228499594575835 47.633904528310005 0.5696234406278612 0.20570780758095625 25.93588615406152 0.02999999998491719 1.5228787454986836 1.7746192373166547 EEEEGISQES(ph)SEEEQ ddPTM_A459_Selumetinib_30min_R1 1 EEEEGISQESSEEEQ 15 0 P17096;P17096-2 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 EEEEGISQES(0.793)S(0.207)EEEQ 157.5 0.00015426 2786500.0 2573.1 3432.9 2231.0 2303.9 2455.2 2536.8 3075.4 2946.8 1630.3 2998.9 True False 2633.048223618966 3030.9744720880867 1928.0424540057925 1901.567114559223 2233.127593500765 2511.2820952301095 2843.420101981254 2868.641291444593 2766.500027599143 3383.83802675969 0.7781247810316534 0.8957209086601879 0.5697797704141458 0.5619557140505729 0.6599392689132858 0.7421401601881263 0.8402943874663139 0.8477478143927472 0.8175627809964355 1.0 11.724444797687573 -7.242281832989237 2.2600445185554423 0.8729120886921233 0.6905093052019812 0.4279789167483974 0.10098015167120036 0.3657892336347554 3.6613110941223885 0.05337920066261618 0.03536429889049922 5.7242443877081265e-08 7.242281832989237 -0.18240278349014216 EEEEGISQES(ph)SEEEQ ddPTM_A459_Selumetinib_30min_R2 2 EEEEGISQESSEEEQ 15 0 P17096;P17096-2 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 EEEEGISQES(0.775)S(0.225)EEEQ;EEEEGISQES(0.816)S(0.184)EEEQ 225.31 2.7266e-10 11180300.0 54120.0 40371.0 51666.0 48236.0 50512.0 47022.0 51070.0 51906.0 44430.0 47390.0 True False 51112.22705952545 43467.32588677518 48341.86580968748 41666.17358825879 44166.230976990555 53498.85367678336 53444.85619328521 52057.03786649914 53317.24147792321 46021.72756599292 1.1106107867470425 0.9444957455029289 1.0504139754503476 0.9053587466596407 0.9596821612934526 1.1624694792273629 1.1612961750870365 1.131140455165484 1.1585232519024602 1.0 15.490027520089097 -6.761607743629633 24.999999845834846 1.1332953063648332 0.9895529185458076 0.4564810901082791 0.06958022422479518 3.6905220675767416 547934.0228665121 0.02282637111070892 0.02141635800072814 1.7313794414855294e-07 6.761607743629633 -0.1437423878190256 EEEEKESDS(ph)DSEGPIQYR ddPTM_A459_Selumetinib_30min_R2 1 EEEEKESDSDSEGPIQYR 18 1 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 EEEEKES(0.015)DS(0.699)DS(0.285)EGPIQYR 52.464 0.044905 6694300.0 23301.0 17162.0 18668.0 17412.0 17172.0 17300.0 30114.0 26086.0 20043.0 13977.0 True False 22006.023701293467 18478.270215472403 17466.921204181595 15040.455562624631 15014.69984037221 19682.917966236055 31514.36066975897 26161.905941230223 24052.160048210986 13573.447693392758 1.6212552770955526 1.3613542139678483 1.2868448458149724 1.1080792369315262 1.1061817291771066 1.4501045284034393 2.3217653599607884 1.9274326267131996 1.7720007909205724 1.0 13.728499595398747 -7.01579188588436 24.18116208588716 1.8402071313963508 1.2881854739049414 0.28007118204002857 0.3364463283159084 487.8156348625802 746961.591535397 0.1221096087303686 0.09763629673559493 9.64291001616949e-08 7.01579188588436 -0.5520216574914094 EEEELNLPIS(ph)PEEER ddPTM_A459_Selumetinib_30min_R2 1 EEEELNLPISPEEER 15 0 Q5JTD0-4;Q5JTD0-2;Q5JTD0 Q5JTD0-4 TJAP1 Tight junction-associated protein 1 1 EEEELNLPIS(1)PEEER 166.62 7.834e-05 4050200.0 15453.0 12001.0 14067.0 16387.0 15390.0 11003.0 13594.0 18071.0 13576.0 12077.0 True False 14594.184123260287 12921.438110702964 13161.944534991566 14155.062330848248 13456.570611654352 12518.56337471071 14226.147935999983 18123.583618184908 16291.579345133581 11728.305630185621 1.2443557137271932 1.1017310187966562 1.122237512391912 1.2069145175085465 1.1473584536389148 1.0673803846389516 1.2129755469012986 1.545285754793045 1.3890820941094233 1.0 13.517706984092879 -7.536371471619665 24.945557601356253 1.3561365583551375 1.1470220807364357 0.20300203237396675 0.13629581180432135 260.9979385673185 482530.57391006505 0.06023454514522619 0.03479951439273631 2.908228515151534e-08 7.536371471619665 -0.20911447761870172 EEEEQQEGGFAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 EEEEQQEGGFASPR 14 0 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 EEEEQQEGGFAS(1)PR;EEEEQQEGGFAS(1)PR 160.03 2.0600000000000006e-05 1545300.0 7506.2 8623.2 5524.4 7717.6 10143.0 7350.799999999999 5983.0 6813.299999999999 6285.4 6226.4 True False 7089.035453699368 9284.571712041818 5168.966118511934 6666.449566397422 8868.745660429502 8363.305976081387 6261.221355089592 6833.125574997463 7542.655628749462 6046.627653869973 1.1723949049785183 1.5354958571162374 0.8548510697865914 1.1025070416119884 1.4667259451230328 1.3831356013345206 1.035489815729314 1.1300721602435888 1.2474152636010254 1.0 12.561915026467073 -9.638985787293914 0.43103996108847936 0.9658150308727508 1.2340376570041687 0.09983674705655987 0.19451347736773658 13.262012775885845 2.959749096999735 0.9805253606594992 0.12520341800066348 2.2962237930226238e-10 9.638985787293914 0.2682226261314179 EEEESSSNGTASQST(ph)SPSQPR ddPTM_A459_Selumetinib_30min_R2 1 EEEESSSNGTASQSTSPSQPR 21 0 Q92793-2;Q92793;I3L466 Q92793-2 CREBBP CREB-binding protein 1 EEEESSSNGTASQS(0.007)T(0.897)S(0.096)PSQPR 216.34 6.3322e-20 3160500.0 13275.0 11933.0 11753.0 12798.0 17426.0 11373.0 16452.0 14334.0 16757.0 8608.8 True False 12537.228644035478 12848.22272935743 10996.82477569885 11054.890322218593 15236.790089583412 12939.527516185124 17217.050599019545 14375.709566878564 20108.86822969972 8360.2415756514 1.4996251640083287 1.5368243385187519 1.3153716523845802 1.3223170912208042 1.8225298816674702 1.5477456481485612 2.059396303710046 1.7195327954094988 2.4052975081803076 1.0 13.029328915360452 -6.268500761780598 24.35962151643795 1.799509079144804 1.4196150499355744 0.18480265302725418 0.34416856236149046 584.7027308488877 2017043.1062770435 0.10053052684946234 0.11651069466024558 5.388889001264883e-07 6.268500761780598 -0.37989402920922966 EEEMGEEEEVER ddPTM_A459_Selumetinib_30min_R2 1 EEEMGEEEEVER 12 0 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YDJ9;A0A2R8Y5Z7;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 187.42 3.7433e-12 0.0 8458.5 8497.3 7348.1 10474.0 10367.0 7702.2 6437.5 5017.9 4281.9 6889.8 False True 7988.410432058315 9149.015586874115 6875.331246006356 9047.4231313422 9064.60477784409 8763.108136389792 6736.856505664253 5032.501258241934 5138.399646282225 6690.873572149775 1.19392637537039 1.3673873057407868 1.027568548690618 1.3522035700990338 1.3547714928548016 1.309710614300878 1.0068724857850966 0.7521441264694221 0.7679714152230288 1.0 12.707978868612738 -7.462787136244058 3.4149468466681845 0.8234085879005384 1.2680059315146854 0.7409736889240957 0.11450957120013507 0.11878078327797116 2.7382885891357915 0.05452495224480848 0.03312486168280079 3.445187507438711e-08 7.462787136244058 0.44459734361414704 EEEMQPAEEGPS(ph)VPK ddPTM_A459_Selumetinib_30min_R1 1 EEEMQPAEEGPSVPK 15 0 Q6ZU67-5;Q6ZU67-4;Q6ZU67-2;Q6ZU67 Q6ZU67-5 BEND4 BEN domain-containing protein 4 1 EEEMQPAEEGPS(1)VPK 102.73 0.0061076 53545000.0 1735.4 1916.8 2137.1 2205.3 2279.9 1723.8 1999.0 1510.2 1194.3 1988.6 True False 1775.8314434994184 1692.3801649038564 1846.893558250012 1820.185753607991 2073.683447549037 1706.4601370851708 1848.2138205958668 1470.1445901790498 2026.6398717792154 2243.856180604329 0.7914194585417416 0.7542284481209729 0.8230890973380457 0.8111864607640618 0.9241605881311608 0.7605033476903037 0.8236774872523669 0.6551866393607729 0.9031950841133626 1.0 11.131764494397471 -8.521161643560362 24.780374832210992 1.0000000080372873 0.7964244259112048 0.522326609817632 0.06405635434282687 98.1417113613877 1416323.9462723613 0.06142727626743281 0.015860454460227616 3.011884797883914e-09 8.521161643560362 -0.2035755821260825 EEENADS(ph)DDEGELQDLLSQDWR ddPTM_A459_Selumetinib_30min_R1 1 EEENADSDDEGELQDLLSQDWR 22 0 J3QQQ3;Q96NB3 J3QQQ3 ZNF830 Zinc finger protein 830 1 EEENADS(1)DDEGELQDLLSQDWR 83.46700000000001 0.00051646 605060.0 213.12 77.321 160.24 256.52 306.22 127.89 292.25 188.89 163.81 67.515 True False 218.0852813406686 68.26822137444232 138.48028813531516 211.7235974767704 278.522455067532 126.60354271482922 270.205347208175 183.8800235988087 277.9736057909684 76.1812079017908 2.8627175565634744 0.8961294163575153 1.81777490734772 2.7792102975016415 3.65605196791563 1.6618736588955179 3.546876646488868 2.413718929684839 3.6488474447572266 1.0 6.2513632578228515 -5.7519831808786535 7.355200435997052 2.767660051548881 1.7579899966054844 0.13091035294637887 0.9279576885259656 0.2165439334080506 64.52277609428347 0.23828280258725149 0.3921202691555033 1.7701775114653547e-06 5.7519831808786535 -1.0096700549433966 EEENKSSS(ph)EGGDAGNDTR ddPTM_A459_Selumetinib_30min_R1 1 EEENKSSSEGGDAGNDTR 18 1 Q9Y3E1;H3BPM9 Q9Y3E1 HDGFRP3 Hepatoma-derived growth factor-related protein 3 1 EEENKS(0.021)S(0.054)S(0.924)EGGDAGNDTR 85.7 0.0041441 5907300.0 1752.9 1996.2 1661.1 1184.9 1188.6 1448.9 2129.4 2107.8 1401.9 2256.7 True False 1793.7391594503467 1762.483975991797 1435.531743769171 977.979458327715 1081.091339864374 1434.325381495942 1968.7776436102235 2051.894296900676 2378.9219092751255 2546.369427119475 0.7044300565136282 0.6921556460821825 0.5637562752994113 0.38406817483432987 0.4245618598583848 0.56328251754047 0.7731704687631914 0.8058117078564822 0.9342406816304848 1.0 11.31422602519346 -7.654773773721405 1.4824694566689263 0.9531373534006029 0.5476330770800187 0.730624878195814 0.10010981060494442 0.25484735296764827 1.062370497378902 0.08736736915518782 0.03701118138846413 2.2142478225787585e-08 7.654773773721405 -0.40550427632058417 EEENKSSS(ph)EGGDAGNDTR ddPTM_A459_Selumetinib_30min_R2 1 EEENKSSSEGGDAGNDTR 18 1 Q9Y3E1;H3BPM9 Q9Y3E1 HDGFRP3 Hepatoma-derived growth factor-related protein 3 1 EEENKS(0.246)S(0.146)S(0.563)EGGDAGNDT(0.045)R 63.93600000000001 0.02001 6234400.0 25343.0 19122.0 18294.0 24572.0 20621.0 17431.0 30908.0 32107.0 24963.0 16781.0 True False 23934.53751606713 20588.595913079072 17116.98395700117 21225.251210935712 18030.405625921016 19831.962027136462 32345.283243040114 32200.42605440003 29956.297524496895 16296.488927725826 1.4686928958879237 1.263376179027798 1.0503479634732489 1.302443201420178 1.1063981760663313 1.2169469212104702 1.9848007375386163 1.9759118787615806 1.8382056194651306 1.0 13.992273549392985 -7.248063465955 23.884017659246368 1.781055536478119 1.2248718274305666 0.37952643134929054 0.28360202086436737 363.81666018285216 649631.485481834 0.10347765987892878 0.07961845590105221 5.6485442334907266e-08 7.248063465955 -0.5561837090475525 EEENS(ph)EEELAAATTSK ddPTM_A459_Selumetinib_30min_R2 2 EEENSEEELAAATTSK 16 0 P10244-2;P10244 P10244-2 MYBL2 Myb-related protein B 1 EEENS(1)EEELAAATTSK;EEENS(1)EEELAAATTSK 240.42 1.7981e-21 12872700.0 50386.0 35903.0 38650.0 53387.0 54011.0 47407.0 56968.0 62324.0 54678.0 41662.0 True False 47585.747831139095 38656.64465365958 36163.301078938195 46115.59850228816 47225.655315533644 53936.88393210135 59617.124879950454 62505.352521706394 65615.12783096748 40459.109809124195 1.1761442121597971 0.9554497080146305 0.8938234491452597 1.1398075419812705 1.1672440530286576 1.333120876523529 1.473515486653288 1.5449018235099776 1.6217640017420796 1.0 15.304176957278312 -6.652531516739236 1.5224631808167 1.45524145039493 1.0158763485607045 0.4824432344804228 0.1730843152377833 0.2906170589830716 1.396038829420696 0.07131553169191793 0.07076981682028255 2.225709519250303e-07 6.652531516739236 -0.4393651018342255 EEENSEEELAAAT(ph)TSK ddPTM_A459_Selumetinib_30min_R1 1 EEENSEEELAAATTSK 16 0 P10244-2;P10244 P10244-2 MYBL2 Myb-related protein B 1 EEENS(0.226)EEELAAAT(0.758)T(0.013)S(0.003)K 142.95 0.0009192 3363900.0 2238.8 1955.3 2266.4 2012.0 3903.7 4161.9 3050.5 3064.1 2801.4 2025.4 True False 2290.9596840535323 1726.3725670056901 1958.6353284440731 1660.6419699175976 3550.6110242542113 4120.035064702853 2820.3983290283595 2982.830114400495 4753.771193839316 2285.379819066685 1.002441548201439 0.7553985348968011 0.8570283644335105 0.7266371900473765 1.5536196629688575 1.8027791399616953 1.2341048544745479 1.305179160818283 2.08007927355405 1.0 11.158218238806269 -6.2647472069861205 24.868235780580115 1.5134674953436316 0.8312102570063861 0.5550238459889018 0.28950102712049486 195.32812273106893 1468474.1148253253 0.08599346871872539 0.10154250151909859 5.435666372950237e-07 6.2647472069861205 -0.6822572383372455 EEEPTGWEEPS(ph)PESIR ddPTM_A459_Selumetinib_30min_R2 2 EEEPTGWEEPSPESIR 16 0 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 EEEPTGWEEPS(0.5)PES(0.5)IR;EEEPTGWEEPS(1)PESIR 185.63 7.7289e-07 16372500.0 31837.0 15752.5 24189.0 36983.0 40518.0 30046.0 38795.0 40699.0 43833.0 27260.0 True False 30067.626993608847 16960.66609772923 22632.706074991882 31945.851600766513 35427.76660448413 34184.56376956811 40599.04437083413 40817.427351917846 52600.82479634947 26472.93297001407 1.1357875240974051 0.6406795241366192 0.8549376112056787 1.2067363913530709 1.3382637520600085 1.29130247140689 1.5336058311642586 1.5418551241810572 1.9869662668632337 1.0 14.692230421261705 -6.238144288255573 1.0588200544427853 1.540579357361991 0.8354903290341049 0.48873465376004266 0.26006771394432576 0.40445980951538596 0.9470368758214753 0.11181270294781924 0.17499047399723064 5.779040149969923e-07 6.238144288255573 -0.7050890283278861 EEEPTGWEEPS(ph)PESIRR ddPTM_A459_Selumetinib_30min_R1 2 EEEPTGWEEPSPESIRR 17 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 EEEPTGWEEPS(0.993)PES(0.007)IRR;EEEPT(0.001)GWEEPS(0.924)PES(0.075)IRR 132.87 0.0003457 10437300.0 3057.2 3157.6000000000004 2117.1400000000003 2000.5 2904.0 2315.58 3211.3999999999996 2877.8 1771.23 2961.3 True False 3128.4268117243405 2787.906724071587 1829.6440166175805 1651.1502290358624 2641.333712742842 2292.2873675784213 2969.161512487025 2801.4713955881803 3005.647944479192 3341.411700504677 0.9362590103014938 0.8343499616196681 0.5475661728069117 0.49414749723491946 0.7904843669350601 0.6860236250541054 0.8885949349008898 0.8384095246823534 0.899514401061452 1.0 11.7062420349745 -7.6047429090801435 1.1323548631714604 0.9461936487822187 0.702042997092739 0.34991592776536784 0.1271280884442766 0.6406399174842211 1.5116979802055983 0.11290296118888575 0.049151905782981536 2.4846034900078025e-08 7.6047429090801435 -0.2441506516894797 EEEPTGWEEPS(ph)PESIRR ddPTM_A459_Selumetinib_30min_R2 4 EEEPTGWEEPSPESIRR 17 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 EEEPT(0.005)GWEEPS(0.886)PES(0.108)IRR;EEEPTGWEEPS(0.965)PES(0.035)IRR;EEEPTGWEEPS(0.999)PES(0.001)IRR;EEEPTGWEEPS(0.959)PES(0.041)IRR 107.65 0.0012438 22742000.0 79937.9 57897.8 72802.3 76639.3 79189.1 71485.9 79711.4 80611.1 82053.9 67623.7 True False 75495.27153476783 62338.3750892307 68118.27927915087 66200.89512983325 69240.65729846369 81332.43384060997 83418.13804514267 80845.66495511401 98466.97277752338 65671.22807352674 1.149594331481694 0.9492494189302427 1.0372621508293458 1.0080654355315768 1.0543530147013627 1.238478953820517 1.270238740651327 1.2310667445505616 1.4993928949718727 1.0 16.002973813912668 -6.768893393522965 3.6753941714257254 1.2679578153946658 1.0295390262579116 0.4198946212665421 0.12170851976046941 0.1987911100690478 5.767701727611708 0.041295177730779516 0.03834188678758916 1.7025763893559003e-07 6.768893393522965 -0.23841878913675418 EEEQEDLTKDMDEPS(ph)PVPNVEEVTLPK ddPTM_A459_Selumetinib_30min_R1 2 EEEQEDLTKDMDEPSPVPNVEEVTLPK 27 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 EEEQEDLTKDMDEPS(1)PVPNVEEVTLPK;EEEQEDLTKDMDEPS(1)PVPNVEEVTLPK 133.53 2.8989e-12 5222300.0 2454.82 2121.79 3023.62 3685.79 2550.06 2478.6 2778.17 2320.48 1956.4 1954.1899999999998 True False 2512.012529751781 1873.3698404065904 2613.0290115558 3042.1359673472093 2319.407523249659 2453.6675343887373 2568.6104001825006 2258.9333324186764 3319.867910197487 2205.029321922545 1.1392195581152547 0.8495895368743742 1.1850314123158796 1.379635153647208 1.0518715103649454 1.1127595946204503 1.1648871852384042 1.0244459381833222 1.5055890083597276 1.0 11.106582125166415 -5.297258186294072 23.67810735754697 1.178795011520399 0.9944045122208983 0.1688302149380786 0.1629624905766519 457.63576070984715 302520.3778622162 0.040806790728099764 0.08495333861126819 5.043613676475977e-06 5.297258186294072 -0.18439049929950058 EEERQEALR ddPTM_A459_Selumetinib_30min_R1 1 EEERQEALR 9 1 D6RGY3;D6R960;Q6PUV4;D6RI05;D6RBA5;D6RAG3;D6RI11;O14810 D6RGY3 CPLX2;CPLX1 Complexin-2;Complexin-1 0 140.83 0.006365399999999999 1710700.0 971.68 1132.0 1318.2 1627.7 1531.5 987.26 1254.0 1369.5 813.08 877.01 False True 994.3182534398497 999.4649137474773 1139.1956803542964 1343.4527507131586 1392.976095408286 977.3290607603584 1159.4097703988084 1333.1764112370608 1379.7373749863896 989.5827763008159 1.0047853269604545 1.0099861655672728 1.151187861830773 1.3575951228002905 1.407639794030576 0.9876172910099916 1.1716147432687005 1.347210605484304 1.3942617111264004 1.0 9.950676580184357 -5.414778697340438 3.5670651714576174 1.2468655629460528 1.0078413176244692 0.28624843749111384 0.14313515319529516 0.3014737175468444 6.939983797052561 0.03995806932644985 0.09075679834307558 3.847878077293543e-06 5.414778697340438 -0.23902424532158362 EEERQEALR ddPTM_A459_Selumetinib_30min_R2 1 EEERQEALR 9 1 D6RGY3;D6R960;Q6PUV4;D6RI05;D6RBA5;D6RAG3;D6RI11;O14810 D6RGY3 CPLX2;CPLX1 Complexin-2;Complexin-1 0 143.03 0.0058284 3295600.0 19768.0 21626.0 23451.0 28122.0 25064.0 18105.0 12855.0 12487.0 14190.0 21306.0 False True 18669.37369757389 23284.644661450082 21942.188191518224 24291.73508684413 21915.236244997046 20598.799409173633 13452.782971699253 12523.335102665864 17028.39650172699 20690.840420363904 0.9023013719249177 1.12536002348814 1.0604783443171668 1.1740332723718767 1.0591757415241623 0.9955516059608829 0.6501805967465216 0.6052598564503165 0.822992017519388 1.0 14.336704625311262 -7.1254322332118045 4.432560552412418 0.7382142073693791 1.0698980400164035 0.5698813610351252 0.12016092788532692 0.1487399077312409 4.684619177194929 0.04606877131790556 0.035396275188434474 7.491482455815512e-08 7.1254322332118045 0.3316838326470244 EEETS(ph)IDVAGKPNEVTK ddPTM_A459_Selumetinib_30min_R2 1 EEETSIDVAGKPNEVTK 17 1 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 EEET(0.244)S(0.756)IDVAGKPNEVTK 97.271 0.004428199999999999 14767000.0 166740.0 36217.0 105650.0 112270.0 62312.0 50895.0 228410.0 136080.0 97350.0 61599.0 True False 157473.25831310535 38994.72744399044 98852.59402302248 96978.63232344737 54483.80948365208 57905.32427118985 239031.51758582887 136475.97027074313 116822.72018626676 59820.47681657727 2.6324306774744204 0.6518625313461952 1.6524875641851913 1.621161138865629 0.9107886192668009 0.9679850003325835 3.995814314866664 2.2814256511061997 1.952888482391588 1.0 15.868351789474616 EEEWDPEYT(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 EEEWDPEYTPK 11 0 Q9NYF8-2;Q9NYF8;Q9NYF8-4;H0YF14;Q9Y2W1;A0A3B3ITZ9 Q9NYF8-2;Q9Y2W1 BCLAF1;THRAP3 Bcl-2-associated transcription factor 1;Thyroid hormone receptor-associated protein 3 1 EEEWDPEYT(1)PK;EEEWDPEYT(1)PK;EEEWDPEYT(1)PK;EEEWDPEYT(1)PK 216.03 4.8096e-05 65493100.0 23316.899999999998 24415.9 18835.6 18556.5 15916.999999999998 18053.9 20238.1 18600.6 13244.900000000001 21333.5 True False 23860.13840321056 21557.27507735604 16277.828976544813 15315.95562364608 14477.310160374587 17872.29415762964 18711.52382321221 18107.251664736097 22475.6279307783 24071.862530887276 0.9912044974747988 0.8955383094970446 0.6762180930394679 0.6362596830217749 0.6014204402255268 0.7424558085065999 0.777319320397536 0.7522164785338974 0.9336887788362532 1.0 14.55506015244278 -8.357956191423966 2.962985901614433 0.9985355110707782 0.7502656427651233 0.36788843253999015 0.10994517168390762 0.2943790371748545 4.772815030480274 0.11608828402915483 0.03166736173146194 4.385749359018917e-09 8.357956191423966 -0.2482698683056549 EEEWDPEYT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 EEEWDPEYTPK 11 0 Q9NYF8-2;Q9NYF8;Q9NYF8-4;H0YF14;Q9Y2W1;A0A3B3ITZ9 Q9NYF8-2;Q9Y2W1 BCLAF1;THRAP3 Bcl-2-associated transcription factor 1;Thyroid hormone receptor-associated protein 3 1 EEEWDPEYT(1)PK;EEEWDPEYT(1)PK 175.74 0.00017380000000000002 33649000.0 232299.0 209927.0 204986.0 216767.0 195978.0 199306.0 245869.0 216241.0 154117.0 181184.0 True False 219388.75154657624 226027.72587830466 191797.4239318818 187242.96065606817 171357.49157445077 226758.5923802683 257302.39568018098 216870.22550937522 184944.70638877052 175952.74714743296 1.2468617575078138 1.2845933328276669 1.090050749654806 1.0641661678585501 0.9738835815440167 1.2887470986188383 1.462338041614003 1.2325481075192137 1.051104398124589 1.0 17.42482851347488 EEGAAPS(ph)PTHVAELATMEVESAR ddPTM_A459_Selumetinib_30min_R1 2 EEGAAPSPTHVAELATMEVESAR 23 0 Q9NRS6 Q9NRS6 SNX15 Sorting nexin-15 1 EEGAAPS(0.986)PT(0.014)HVAELATMEVESAR;EEGAAPS(0.723)PT(0.277)HVAELATMEVESAR 107.36 1.2705999999999997e-05 18205500.0 4484.9 5589.2 3457.1000000000004 2912.7 4573.9 3741.3 5272.5 5330.299999999999 2698.3 5311.7 True False 4589.3894439037385 4934.813865651416 2987.644808491001 2404.0516231505912 4160.191552587635 3703.6659188286067 4874.791080085898 5188.923128745462 4578.818023965386 5993.50843533944 0.7657267013830139 0.8233597931646081 0.4984801207377957 0.4011092416214208 0.694116242175944 0.6179462261187009 0.813345160464401 0.865757207940192 0.7639628897437375 1.0 12.549185049030875 -7.340824440151174 3.31752760218804 0.8593241764890248 0.62687982770753 0.44025908054529084 0.12624179265628763 0.2802599178257289 5.985664912118601 0.06244942166840351 0.0405896172332167 4.5622130225986364e-08 7.340824440151174 -0.23244434878149478 EEGAAPS(ph)PTHVAELATMEVESAR ddPTM_A459_Selumetinib_30min_R2 2 EEGAAPSPTHVAELATMEVESAR 23 0 Q9NRS6 Q9NRS6 SNX15 Sorting nexin-15 1 EEGAAPS(0.904)PT(0.096)HVAELATMEVESAR;EEGAAPS(0.713)PT(0.287)HVAELATMEVESAR 84.37100000000002 0.00023767 18941600.0 86174.0 59895.0 76694.0 86955.0 90157.0 79519.0 83596.0 89950.0 87291.0 69091.0 True False 81384.7940618541 64488.75390722056 71759.59153811351 75111.57899425825 78830.67164619379 90472.0204483888 87483.3796423315 90211.73960797593 104751.63911432374 67096.1633100235 1.2129574933488934 0.9611392175919927 1.0695036496579133 1.1194616098568682 1.1748908992299605 1.3483933504566448 1.3038507021348917 1.3445141295359162 1.5612165278409427 1.0 16.03394265220657 -6.535961713057758 1.9833009861979913 1.3358014369950981 1.075160607973874 0.34497695045292365 0.14125517888709996 0.32562135331407815 2.585085985281538 0.05029628082776696 0.05398016644359797 2.91097373512092e-07 6.535961713057758 -0.2606408290212241 EEGAQTLEEDRAQT(ph)PHEDGGPQPHR ddPTM_A459_Selumetinib_30min_R1 1 EEGAQTLEEDRAQTPHEDGGPQPHR 25 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 EEGAQT(0.001)LEEDRAQT(0.999)PHEDGGPQPHR 91.883 1.9021e-05 17694000.0 1565.8 1507.0 1797.0 2108.6 1906.5 1511.3 1522.1 1720.9 868.02 1060.0 True False 1602.2800934835718 1330.5597394147069 1552.9772702144367 1740.372593324178 1734.057411619913 1496.0976941506085 1407.2867715502593 1675.2561417289949 1472.966542327551 1196.0613252743583 1.3396303848517408 1.1124511020448693 1.2984094020916588 1.4550864211958054 1.4498064396674197 1.2508536665604721 1.1766008496491174 1.400644019105556 1.231514230250422 1.0 10.224075646941431 -8.546832329007232 20.302948210199467 0.999999994565235 1.3070566810870208 0.4420842562995341 0.10499216315087731 445.001929162741 377182.7383604169 0.10827356360062836 0.027956113916157762 2.839014894466305e-09 8.546832329007232 0.30705668652178575 EEGAQTLEEDRAQT(ph)PHEDGGPQPHR ddPTM_A459_Selumetinib_30min_R2 1 EEGAQTLEEDRAQTPHEDGGPQPHR 25 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 EEGAQT(0.12)LEEDRAQT(0.88)PHEDGGPQPHR 66.40100000000001 0.0011424000000000002 19452000.0 19510.0 21156.0 25856.0 23268.0 26805.0 28011.0 19367.0 19011.0 18251.0 22945.0 True False 18425.712304718054 22778.59717273826 24192.453109884264 20098.858260461173 23437.51626025956 31869.260991458843 20267.60387498246 19066.31886255952 21901.709975547517 22282.518231730475 0.8269133727659067 1.0222631452984234 1.0857144986168585 0.9020012034295228 1.0518342683047537 1.4302360559084732 0.9095742080947222 0.8556626618354535 0.9829099991202662 1.0 14.443624665868768 EEGGEGT(ph)PVKQDLSAPPGYTLTENVAR ddPTM_A459_Selumetinib_30min_R1 3 EEGGEGTPVKQDLSAPPGYTLTENVAR 27 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 EEGGEGT(0.93)PVKQDLS(0.07)APPGYTLTENVAR;EEGGEGT(0.897)PVKQDLS(0.103)APPGYTLTENVAR;EEGGEGT(1)PVKQDLSAPPGYTLTENVAR 136.96 5.4556e-12 74755000.0 5153.3 5272.37 4605.54 4605.36 5250.9 4725.43 4879.71 4599.87 2776.02 4296.75 True False 5273.3618634237355 4655.078469341686 3980.1329644203634 3801.1203293139715 4775.95702212169 4677.896464547155 4511.6295460229385 4477.86650511648 4710.703187521172 4848.279716389242 1.0876769023036224 0.9601505568264856 0.8209371565270513 0.7840142383832708 0.9850828131835978 0.9648569674587629 0.9305629645855038 0.9235990427654972 0.9716236403598987 1.0 12.243257220644223 EEGGEGT(ph)PVKQDLSAPPGYTLTENVAR ddPTM_A459_Selumetinib_30min_R2 2 EEGGEGTPVKQDLSAPPGYTLTENVAR 27 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 EEGGEGT(0.969)PVKQDLS(0.025)APPGY(0.002)T(0.003)LT(0.001)ENVAR;EEGGEGT(0.992)PVKQDLS(0.007)APPGYTLTENVAR 84.125 9.7823e-05 48117000.0 85406.0 84159.0 99761.0 97236.0 120213.0 84840.0 95189.0 106597.0 65454.0 80704.0 True False 80659.4764273066 90613.72468616378 93342.48587156428 83992.28905854402 105110.76822214441 96525.93989915993 99615.47711342524 106907.1796219166 78546.62893756446 78373.86582582592 1.0291629177328077 1.1561727079730773 1.190989941455789 1.071687458230071 1.3411456371915762 1.2316087624626588 1.27102926547997 1.3640666884992205 1.0022043459247305 1.0 16.258085039897352 -3.60378270699402 0.8339334064851007 1.2111859025906493 3.6052684420998513e-10 0.10236626582778463 0.12278960264962038 26.822708239799006 3.177400017915743 0.041586280074931765 47.0190402413243 0.0002490102893869539 3.60378270699402 -1.2111859022301223 EEGPPPPSPDGASS(ph)DAEPEPPSGR ddPTM_A459_Selumetinib_30min_R2 1 EEGPPPPSPDGASSDAEPEPPSGR 24 0 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 EEGPPPPSPDGAS(0.032)S(0.866)DAEPEPPS(0.102)GR 101.51 2.7995e-06 36495000.0 29129.0 29444.0 37737.0 47911.0 59436.0 38037.0 33361.0 35942.0 40626.0 43048.0 True False 27510.126792625946 31702.260122617932 35309.04250493895 41385.43914891503 51969.1183154183 43276.25148449254 34912.35260356738 36046.58526948158 48752.33518528262 41805.09238786372 0.6580568352149441 0.7583348896466331 0.8446110387066 0.9899616717730179 1.2431288952373005 1.0351909064804723 0.8351220057033687 0.8622534531210874 1.1661817353006432 1.0 15.351391071023906 -5.485517336371321 2.090918106587592 1.0156208864732448 0.6952772766015716 0.5431170109258336 0.11645547068024928 0.28676203821934 2.4331622843825143 0.036962387053034645 0.09839370672216456 3.269509951902577e-06 5.485517336371321 -0.3203436098716732 EEGS(ph)DIEDEDMEELLNDTR ddPTM_A459_Selumetinib_30min_R1 2 EEGSDIEDEDMEELLNDTR 19 0 F5H5U2;Q8NHQ9-2;Q8NHQ9 F5H5U2 DDX55 ATP-dependent RNA helicase DDX55 1 EEGS(1)DIEDEDMEELLNDTR;EEGS(1)DIEDEDMEELLNDTR 292.19 5.734099999999996e-152 0.0 1275.29 1383.81 1345.1 1558.73 1074.31 1172.98 1184.13 1332.3 779.61 946.83 True False 1305.0017757176295 1221.792881884184 1162.4428081054195 1286.527066485913 977.1388501848356 1161.1808861806262 1094.810120751468 1296.9630760796915 1322.9412295384693 1068.3648534052072 1.221494484359147 1.1436101421625342 1.0880578899618019 1.2042019749951114 0.9146115646451619 1.0868767186411887 1.0247530300739225 1.2139701825138403 1.2382859893994538 1.0 10.06118870538454 -4.498919866558737 1.244040932560141 1.0960534376542015 1.3569570830997466 0.13854117624172047 0.09651534439723355 5.8455263090475444 4.956801938959207 0.02973125459267262 2.316521528848257 3.170152346785669e-05 4.498919866558737 0.2609036454455451 EEGS(ph)DIEDEDMEELLNDTR ddPTM_A459_Selumetinib_30min_R2 3 EEGSDIEDEDMEELLNDTR 19 0 F5H5U2;Q8NHQ9-2;Q8NHQ9 F5H5U2 DDX55 ATP-dependent RNA helicase DDX55 1 EEGS(1)DIEDEDMEELLNDTR;EEGS(1)DIEDEDMEELLNDTR;EEGS(1)DIEDEDMEELLNDTR 284.46 4.802199999999997e-151 8728400.0 43151.2 35152.1 44284.5 43089.0 45990.4 33215.3 35499.8 39284.8 33160.7 37087.0 True False 40753.02905194001 37848.15303818361 41435.28348331794 37220.20386732903 40212.674792607395 37790.40607652722 37150.611041519194 39399.11226405125 39793.76658737267 36016.20194640175 1.1315193398956243 1.0508646384898697 1.150462326510183 1.0334294527423808 1.1165162515595262 1.049261277820626 1.0314971883155708 1.0939274586110952 1.104885147151068 1.0 15.136358430810429 -6.071366758047666 0.9634235518537845 1.0626256957460694 1.1038420501292112 0.15223938352068778 0.04351823423482393 1.3726847021075994 2.6230902617088283 0.01870205819902355 0.03729904091145239 8.484636519651124e-07 6.071366758047666 0.04121635438314186 EEGS(ph)LSDTEADAVSGQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R2 1 EEGSLSDTEADAVSGQLPDPTTNPSAGK 28 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 EEGS(0.552)LS(0.442)DT(0.007)EADAVSGQLPDPTTNPSAGK 148.7 2.7333999999999998e-14 17617000.0 87919.0 60007.0 76908.0 85791.0 95054.0 92687.0 110170.0 111820.0 94658.0 72498.0 True False 83032.81394764254 64609.34394708382 71959.82301109903 74106.11780227038 83112.46672645822 105453.7929211861 115293.12329771338 112145.37768720236 113592.24496550181 70404.79436757448 1.179363063176334 0.9176838669504047 1.0220869708873226 1.052572036719144 1.1804944176463126 1.4978211905658763 1.6375748886614545 1.5928656378386052 1.6134163303205056 1.0 16.103386055213313 -6.647015245008086 2.8087822224345964 1.520637985016339 1.0357669934554843 0.5427407715692744 0.18284881152481386 0.17640817196292113 2.8139547804988707 0.0621519961900494 0.061601553919834066 2.2541600831436917e-07 6.647015245008086 -0.48487099156085467 EEGSLS(ph)DTEADAVSGQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R1 1 EEGSLSDTEADAVSGQLPDPTTNPSAGK 28 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 EEGS(0.452)LS(0.525)DT(0.023)EADAVSGQLPDPTTNPSAGK 119.41 2.6769e-12 20027000.0 2814.9 2977.6 1413.7 1382.3 2284.0 1926.8 2936.0 2558.1 1435.8 2519.6 True False 2880.4816931580704 2628.981207751315 1221.7273048982472 1140.9072539846406 2077.4126032729528 1907.418141394425 2714.53515621284 2490.2508781201345 2436.4477333170867 2843.0152029823303 1.013178434690197 0.9247158456956217 0.42972943078765535 0.4013018476960046 0.730707525268856 0.6709138028504169 0.9548085263016833 0.8759189453182856 0.8569942681844426 1.0 11.473206098488843 -7.2563080609699755 24.01817608920735 0.9115903530189059 0.6817315914339526 0.27140787699292634 0.1809688436817586 383.31677968977834 1794199.0634846925 0.07862019118207651 0.05894612163245897 5.542324361412717e-08 7.2563080609699755 -0.22985876158495333 EEGSLS(ph)DTEADAVSGQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R2 3 EEGSLSDTEADAVSGQLPDPTTNPSAGK 28 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 EEGS(0.204)LS(0.782)DT(0.015)EADAVSGQLPDPTTNPSAGK;EEGS(0.217)LS(0.778)DT(0.004)EADAVSGQLPDPTTNPSAGK;EEGS(0.255)LS(0.726)DT(0.019)EADAVSGQLPDPTTNPSAGK 150.62 1.9218e-14 32124900.0 174883.0 108888.0 162471.0 165080.0 174378.0 184306.0 192431.0 205971.0 188926.0 134674.0 True False 165163.7029721174 117239.35946989642 152017.79274504966 142595.8192211159 152471.07668090067 209692.47853671128 201379.42279479268 206570.3415096655 226716.4790334936 130785.61169492574 1.2628583590478055 0.8964239869395748 1.1623434013494598 1.0903020399043513 1.1658092561172484 1.6033298756582333 1.5397674116059195 1.5794577005268546 1.733497103353685 1.0 16.996844306724093 -6.6885498159565 5.199076926193294 1.5301911516394484 1.0978568079051592 0.4615455355465963 0.20103593202550468 0.1591869144744291 7.809710499848181 0.06346341728438123 0.06269022591974296 2.048567054615222e-07 6.6885498159565 -0.43233434373428925 EEHGGLIR ddPTM_A459_Selumetinib_30min_R2 2 EEHGGLIR 8 0 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 0 ; 128.61 0.0060217 6500600.0 54814.0 45116.0 49322.0 60182.0 60222.0 50044.0 50973.0 57351.0 53452.0 44875.0 False True 51767.65731782754 48576.25212919544 46148.67621773323 51985.107780259365 52656.373968489126 56937.10674579866 53343.345501083335 57517.88191503088 64143.89357366531 43579.34215074765 1.1878944188454073 1.1146623544972916 1.0589576147822024 1.1928841789404456 1.2082874905808036 1.3065159760522416 1.2240511872932935 1.3198428217678841 1.4718876056408035 1.0 15.411356798054271 -6.318483733560391 1.8155747640543922 1.281814581007695 1.1222990112277353 0.2061892571147469 0.11511279336678831 0.4777536686643665 3.107600015766317 0.03983540742583459 0.05041415200059386 4.803040696251326e-07 6.318483733560391 -0.15951556977995973 EEHGGLIRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 EEHGGLIRSPR 11 1 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 1 EEHGGLIRS(1)PR;EEHGGLIRS(1)PR;EEHGGLIRS(1)PR 75.911 0.028805 1791410000.0 13036.3 13863.7 13588.5 15094.0 13429.4 12695.0 12898.599999999999 11300.2 6465.1 10775.8 True False 13340.020425775889 12240.53155894072 11743.256336287628 12458.116249471293 12214.713141153135 12567.299826137747 11925.64821727756 11000.481987777326 10970.80250777846 12158.978895180591 1.097133282389644 1.006707196752554 0.965809418498313 1.0246021772773428 1.0045837932981885 1.0335818438766269 0.980810010452809 0.9047208719259761 0.9022799202428845 1.0 13.569734456627465 -7.5562267354770745 4.380775611770531 0.9283789153013111 1.0176673133849718 0.4790181533158788 0.040033111270139 0.1711856268555106 7.571101966030667 0.019323018261043986 0.011080059125232824 2.7782624201281892e-08 7.5562267354770745 0.08928839808366074 EEHGGLIRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 EEHGGLIRSPR 11 1 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 1 EEHGGLIRS(1)PR;EEHGGLIRS(1)PR;EEHGGLIRS(1)PR 148.89 0.0030422 327027800.0 128295.0 136674.0 137393.0 134843.0 147538.0 101322.0 84527.0 97871.0 79638.0 135990.0 True False 121164.87750557682 147156.4563238242 128553.28396218768 116477.15078285063 129002.95743354503 115278.18579046067 88457.67298707306 98155.78840658364 95567.82527163738 132063.61535554705 0.9174735764985064 1.1142846265994126 0.9734193904664149 0.8819776020008697 0.9768243666981099 0.8728989092120797 0.6698110811893473 0.743246261601461 0.723649924427298 1.0 17.010873521063637 -6.974941864637121 3.748011914005154 0.7623910360373282 0.9747819845444244 0.4369922702900445 0.09944032532464268 0.18868969127625876 5.758828998641658 0.03692741096550262 0.030870936082098194 1.0593955280876409e-07 6.974941864637121 0.21239094850709628 EEHLCTQR ddPTM_A459_Selumetinib_30min_R1 2 EEHLCTQR 8 0 J3KN67;P06753-7;P06753-2;A0A087WWU8;P06753-5 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 ; 167.23 0.00033397 20551000.0 13077.2 14398.3 10780.5 12239.0 13589.0 11692.5 13307.7 12613.7 7146.8 11627.900000000001 False True 13381.87331619834 12712.540342411921 9316.567313047708 10101.68840448384 12359.877349332803 11574.884065940578 12303.889474909263 12279.143700928022 12127.597618380383 13120.454230337455 1.0199245453908468 0.9689100788155379 0.7100796321140849 0.7699191070021383 0.9420312080929313 0.8822014743343893 0.9377639873518929 0.9358779418273391 0.9243275732282681 1.0 13.67953004649566 -7.213819676299818 1.3504884351148698 0.9515895997339885 0.8702551687669954 0.12594160754103534 0.08704272513843173 1.057335238014623 3.786834127853357 0.057900325705974656 0.035114115768502964 6.111957472198298e-08 7.213819676299818 -0.08133443096699311 EEHLCTQR ddPTM_A459_Selumetinib_30min_R2 3 EEHLCTQR 8 0 J3KN67;P06753-7;P06753-2;A0A087WWU8;P06753-5 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 ;; 167.23 0.00033397 55289000.0 109664.0 107305.0 99193.0 104935.0 111712.0 91454.0 109821.0 104666.0 104233.0 102326.0 False True 103569.31389977453 115534.9484600432 92811.03037317234 90642.67197702806 97677.73984204873 104050.95836324584 114927.89410618313 104970.560731611 125082.51251335526 99371.58250512299 1.0422427749345253 1.162655817160675 0.9339795949046859 0.912158885789658 0.9829544561898576 1.0470896783583135 1.1565468840174518 1.0563438569190478 1.2587352375806915 1.0 16.600545719863327 -7.065230228515744 4.457407563032058 1.1218792315893993 1.0065531406552315 0.25582963237730794 0.08919226795601298 0.3214994980397269 12.53345126954578 0.03574609153998569 0.027983730145151122 8.605374424926858e-08 7.065230228515744 -0.11532609093416779 EEIFGPVQQIMK ddPTM_A459_Selumetinib_30min_R2 2 EEIFGPVQQIMK 12 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 181.62 0.0014421 15883600.0 49109.0 45064.0 48670.0 55904.0 48311.0 43638.0 45747.0 42063.0 41331.0 48000.0 False True 46379.71837890306 48520.26389640181 45538.62518788932 48289.77876022098 42241.740274180185 49648.73839367681 47874.32614596076 42185.39636609546 49598.354884628454 46614.11528102256 0.9949715466933913 1.0408920903869494 0.9769278020906451 1.0359475551363861 0.9062006222689708 1.0651009483792497 1.0270349626361193 0.9049918916571155 1.0640200845948657 1.0 15.508479264952376 -5.26807687809704 24.887390483766772 0.9957124143922312 1.0179318184772226 0.02105183895233098 0.05454249996552268 2063.049658337335 7735448.9897246845 0.01362266606277534 0.029479008461078905 5.394151276818262e-06 5.26807687809704 0.022219404084991345 EEIQET(ph)QTPTHSR ddPTM_A459_Selumetinib_30min_R1 1 EEIQETQTPTHSR 13 0 H7BZL0;Q9BYG3 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 EEIQET(0.749)QT(0.218)PT(0.033)HSR 188.63 0.00035065 16501000.0 4939.0 8145.8 6049.7 6357.2 6395.3 5681.4 6843.6 6183.5 3995.3 6121.2 True False 5054.069090378951 7192.0859491203155 5228.1839686234125 5247.034359423537 5816.846244181921 5624.250274298465 6327.381742186032 6019.493493161273 6779.732294833375 6906.915645537169 0.7317403816339619 1.0412876482380968 0.7569491560247371 0.7596783613267165 0.8421771080902681 0.8142925964258033 0.9160936758036712 0.871516868321782 0.9815860859997656 1.0 12.753825888721606 -8.05814606242452 1.054832444694775 1.0026873595809784 0.8299939807596393 0.3565007734029517 0.08365009277744506 0.587831915857554 1.2282370400785334 0.07643430744664594 0.027194160918569816 8.746895491479949e-09 8.05814606242452 -0.17269337882133917 EEIQETQT(ph)PTHSR ddPTM_A459_Selumetinib_30min_R2 1 EEIQETQTPTHSR 13 0 H7BZL0;Q9BYG3 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 EEIQETQT(1)PTHSR 147.09 0.00078995 23190000.0 24074.0 25756.0 24653.0 23893.0 27002.0 18915.0 24939.0 21386.0 19620.0 26186.0 True False 22736.063455857653 27731.40238140702 23066.852820156877 20638.73218227604 23609.76735905721 21520.36955672574 26098.712915691016 21448.229719357118 23544.548228603486 25429.942140601186 0.894066660873659 1.0905019849467665 0.9070745301983434 0.8115917868851321 0.9284239511250045 0.8462610507621461 1.026298556693217 0.8434242437820215 0.9258592921063906 1.0 14.634240559093682 -5.463805754388811 24.998426980071365 0.9041787799069879 0.9939104805447649 0.14465793012402572 0.07750448656427349 396.924406533611 167968.63249961188 0.019030316649952486 0.03961465838973834 3.4371164441842246e-06 5.463805754388811 0.08973170063777702 EEIVT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 EEIVTPK 7 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 EEIVT(1)PK;EEIVT(1)PK 114.86 0.031488 30474000.0 262350.0 224682.0 223580.0 230220.0 221840.0 216050.0 285330.0 281040.0 221280.0 207661.0 True False 247769.63727026037 241914.38693350184 209195.1062154983 198863.63884834835 193970.47592523706 245808.92639336994 298598.41037066886 281857.7798713237 265542.18307978456 201665.2873619255 1.2286181747560359 1.1995836769832475 1.0373382001041118 0.9861074330132529 0.9618436492598814 1.2188955749842092 1.4806634016035642 1.3976514429351345 1.3167471038445016 1.0 17.621603248716532 -6.993282373803901 11.030236599494952 1.3344852010210018 1.0821349622974565 0.335207450524185 0.14089113571024628 0.22226645880151452 336.1562013756494 0.050739670915422565 0.043840299628564804 1.0155881531875732e-07 6.993282373803901 -0.25235023872354523 EEKDKDDQEWESPS(ph)PPKPTVFISGVIAR ddPTM_A459_Selumetinib_30min_R1 1 EEKDKDDQEWESPSPPKPTVFISGVIAR 28 3 P51397 P51397 DAP Death-associated protein 1 1 EEKDKDDQEWES(0.133)PS(0.86)PPKPT(0.006)VFIS(0.001)GVIAR 48.20399999999999 0.022926 77273000.0 2934.2 3196.9 3516.7 3194.9 2146.7 2514.6 2411.2 2333.8 1992.8 2302.0 True False 3002.5611510406807 2822.6054618015114 3039.1514558503673 2636.970690700663 1952.5313640306667 2489.3054070741214 2229.3212427317435 2271.900042749216 3381.6360516466734 2597.4841233788406 1.155949760776559 1.0866689949695747 1.1700365859780502 1.0152018512707819 0.7517009811366195 0.9583525014335799 0.8582617397606318 0.8746540632532912 1.3018890168413417 1.0 11.342899215623099 -5.94798037135204 5.704431619044912 0.9409235609793156 1.1291389770782572 0.2528354065225118 0.13621089546123144 0.25700386057722646 18.317075595092618 0.03873092471967029 0.05766308514910959 1.1272484028556411e-06 5.94798037135204 0.18821541609894155 EEKESEDKPEIEDVGS(ph)DEEEEK ddPTM_A459_Selumetinib_30min_R1 2 EEKESEDKPEIEDVGSDEEEEK 22 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 EEKESEDKPEIEDVGS(1)DEEEEK;EEKESEDKPEIEDVGS(1)DEEEEK 136.37 1.7668e-05 22455500.0 3036.1 2815.8 1800.3999999999999 1209.61 1549.38 2105.8 2801.8999999999996 3008.8 1969.62 4474.1 True False 3106.835222777794 2486.124826970095 1555.9155688893 998.3743206918618 1409.2388525652561 2084.6175639134203 2590.5504271773693 2928.996850040211 3342.301284646887 5048.394316424534 0.6154105697865087 0.49245852664117246 0.30820008726878906 0.19776076473339918 0.2791459549782817 0.4129268502524237 0.5131434402319224 0.5801838498452789 0.6620523428158109 1.0 12.301608884390802 -8.444326091120516 0.8432584309875955 0.9924297906746183 0.3736078969541813 0.7361965893677624 0.11257002329671352 0.34857909632801826 0.5545267497884955 0.12171469706774296 0.04423777573027365 3.5947931783326374e-09 8.444326091120516 -0.618821893720437 EEKESEDKPEIEDVGS(ph)DEEEEK ddPTM_A459_Selumetinib_30min_R2 6 EEKESEDKPEIEDVGSDEEEEK 22 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 EEKESEDKPEIEDVGS(1)DEEEEK;EEKESEDKPEIEDVGS(1)DEEEEK;EEKESEDKPEIEDVGS(1)DEEEEK;EEKESEDKPEIEDVGS(1)DEEEEK;EEKESEDKPEIEDVGS(1)DEEEEK;EEKESEDKPEIEDVGS(1)DEEEEK 123.14 3.6594e-05 114187200.0 551843.0 342429.0 372995.0 371176.0 299564.0 311668.0 577976.0 497544.0 269798.0 296536.0 True False 521173.7752625592 368692.2032172241 348996.9077862506 320621.1884856852 261930.09218386104 354597.4379595871 604853.0292377161 498991.77066715725 323765.1387859721 287974.2351869438 1.8097930702871026 1.2802957979135903 1.2119032369673377 1.113367618730016 0.9095608571156524 1.2313512621342448 2.1003720310084844 1.7327653300067887 1.1242850895177965 1.0 18.13558021516414 EEKESEDKPEIEDVGS(ph)DEEEEKK ddPTM_A459_Selumetinib_30min_R1 2 EEKESEDKPEIEDVGSDEEEEKK 23 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 EEKESEDKPEIEDVGS(1)DEEEEKK;EEKESEDKPEIEDVGS(1)DEEEEKK 56.468 0.012372 152088000.0 5295.6 5631.4 3662.77 3400.9900000000002 2611.64 3980.21 5708.6 6866.5 4640.5 7851.099999999999 True False 5418.977176556136 4972.073070033167 3165.3859521554436 2807.0709409890933 2375.4176231224915 3940.172701141532 5277.9957059797725 6684.378114464605 7874.589571289837 8858.865161190108 0.6117010562815866 0.5612539506544667 0.3573128041301176 0.31686574859346756 0.2681401714441916 0.44477172069432486 0.5957868880431997 0.7545411283319069 0.8888937158438427 1.0 13.112906183082924 -7.84464521711098 1.3738811055750995 0.9684288716923651 0.4163274884347975 0.814211105639287 0.10000117357059644 0.2043785047348211 0.7017064289736487 0.0976160784855412 0.03584232586748306 1.430061724327381e-08 7.84464521711098 -0.5521013832575676 EEKESEDKPEIEDVGS(ph)DEEEEKK ddPTM_A459_Selumetinib_30min_R2 1 EEKESEDKPEIEDVGSDEEEEKK 23 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 EEKESEDKPEIEDVGS(1)DEEEEKK 50.358 0.031645 86310000.0 220070.0 141080.0 135480.0 142330.0 104170.0 104430.0 227550.0 176040.0 91569.0 98506.0 True False 207839.3904100104 151900.38235630182 126763.36429947095 122944.40846705505 91083.23330838424 118814.28457884575 238131.5258817713 176552.247255009 109885.35865163084 95661.87583067516 2.1726459846751633 1.587888393754381 1.3251189483660817 1.2851975502202249 0.9521372283103117 1.2420233614188285 2.48930437349224 1.845586297800731 1.1486849666854928 1.0 16.545656460912127 EEKS(ph)VEYEGDLK ddPTM_A459_Selumetinib_30min_R1 1 EEKSVEYEGDLK 12 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 EEKS(1)VEYEGDLK 140.77 0.004971100000000001 16498000.0 1601.2 1863.5 2414.5 2323.3 1763.4 1647.1 1634.4 1865.9 1166.0 1825.3 True False 1638.5048446071617 1645.3205536823534 2086.6241618991403 1917.5792687423254 1603.9007813535566 1630.5316694471428 1511.1158921370104 1816.4102707026163 1978.6168387294367 2059.595034927628 0.7955470938803932 0.7988563410671498 1.0131235153091451 0.9310467525038033 0.7787457020209392 0.7916758594751797 0.7336956374970622 0.8819259319910154 0.9606824667835554 1.0 11.008144982004714 -8.243659174713322 3.128173451853373 0.991145042588736 0.8386894142647532 0.35470875532214885 0.07750932467571471 0.3186836521897524 5.954866616529349 0.07675341978571147 0.022522949645810808 5.7061190097801715e-09 8.243659174713322 -0.15245562832398285 EEKS(ph)VEYEGDLK ddPTM_A459_Selumetinib_30min_R2 1 EEKSVEYEGDLK 12 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 EEKS(0.999)VEY(0.001)EGDLK 110.57 0.033999 12026000.0 41346.0 42471.0 42127.0 41440.0 35527.0 31233.0 37561.0 42096.0 20910.0 39734.0 True False 39048.15484115188 45728.38913421095 39416.59468440958 35795.80051201268 31063.78064459025 35535.06224505497 39307.66092570952 42218.49239063207 25092.58427421505 38586.77617866982 1.0119569113611804 1.1850792852575465 1.0215052561503823 0.927670151718973 0.8050369510205891 0.920912959416864 1.0186821708997342 1.0941181557937407 0.6502897302958895 1.0 15.235818895174425 -5.59955228575416 3.6280251789516336 0.9205687522550233 1.1003222347574084 0.2696068008970912 0.12163319713388487 0.2966314858715169 7.703982238580538 0.03353688612892353 0.06341468148994778 2.5144772708234322e-06 5.59955228575416 0.1797534825023851 EELANERLMT(ph)LK ddPTM_A459_Selumetinib_30min_R1 1 EELANERLMTLK 12 1 B4E3Q4;Q9NZK5;C9IZA8;F5H7J3 B4E3Q4 CECR1 Adenosine deaminase CECR1 1 EELANERLMT(1)LK 87.083 0.016465 6926700.0 5501.7 6066.7 5223.4 4526.1 2833.5 5701.1 4367.4 3817.8 2582.3 2842.9 True False 5629.87890555535 5356.4079436676875 4514.09097008241 3735.7016004195043 2577.210425295055 5643.752110184634 4037.9635017860855 3716.5395420378636 4381.974496270172 3207.8139071910105 1.7550515922805732 1.669800087735806 1.4072172204139077 1.164563066468762 0.8034164386898126 1.7593764081928007 1.2587898234165376 1.1585895097301107 1.3660313917983289 1.0 11.647374734759172 -5.361273737510005 2.604381425776251 1.2313983679371472 1.734647953725652 0.41408839277847453 0.2341305043623554 0.29244560887935017 3.786028700184025 0.06552548902451985 0.1802300385973012 4.352374553413263e-06 5.361273737510005 0.5032495857885049 EELDQYK ddPTM_A459_Selumetinib_30min_R1 1 EELDQYK 7 0 A0A3B3IRX4;Q5SXQ8;A0A1B0GUT5;A0A6E2AE84;Q8IYJ2 A0A3B3IRX4 C10orf67 Uncharacterized protein C10orf67 0 138.37 0.040916 54119000.0 2753.1 3110.3 2093.9 2342.7 2538.7 1983.2 2925.1 2108.0 1379.3 2159.3 False True 2817.241873399938 2746.144630060758 1809.559880969398 1933.5914229254272 2309.075033243889 1963.2508086015266 2704.45735198848 2052.088992250985 2340.5713599138176 2436.4671883631327 1.1562814746102192 1.1271010105026995 0.7426982352202726 0.7936045402788504 0.9477143974161916 0.8057776513380743 1.1099912877568396 0.8422395351975248 0.9606414447494612 1.0 11.250575078706975 -5.154056552126207 7.549144319874586 0.8969331834544612 1.1473525698781677 0.46204964480044686 0.10423239082985217 0.22808243591333616 14.198197839126768 0.02642687586228607 0.07096336359476561 7.013639636055251e-06 5.154056552126207 0.25041938642370654 EELMS(ph)SDLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R2 3 EELMSSDLEETAGSTSIPK 19 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EELMS(0.501)S(0.499)DLEETAGSTSIPK;EELMS(0.5)S(0.5)DLEETAGSTSIPK;EELMS(0.617)S(0.383)DLEETAGSTSIPK 135.57 0.00018764 30421300.0 161862.0 130118.0 145075.0 139185.0 163136.0 150413.0 155804.0 165252.0 139631.0 134690.0 True False 152866.35802492432 140097.63220468682 135741.03244571664 120227.76289248258 142641.39722565596 171131.02543673187 163049.19471976918 165732.85596105875 167561.101616113 130801.14973335262 1.168692770182473 1.0710734002742768 1.0377663554367398 0.9191644197132469 1.0905209741385342 1.3083296728323455 1.246542519329199 1.2670596267610559 1.2810369171654694 1.0 16.9970156965214 -6.6272673011031475 5.836360951896309 1.237956337176305 1.0447751605686049 0.40649272821730054 0.09822285193461823 0.1855335484084904 8.998218565257485 0.031963349714347576 0.03190125734114953 2.3590258446987183e-07 6.6272673011031475 -0.19318117660770007 EELMSS(ph)DLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R1 5 EELMSSDLEETAGSTSIPK 19 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EELMS(0.04)S(0.96)DLEETAGSTSIPK;EELMS(0.169)S(0.831)DLEETAGSTSIPK;EELMS(0.343)S(0.657)DLEETAGSTSIPK;EELMS(0.317)S(0.673)DLEET(0.01)AGSTSIPK;EELMS(0.288)S(0.712)DLEETAGSTSIPK 203.75 5.9931e-16 80065000.0 26274.159999999996 35815.71 21577.329999999998 23836.2 24123.3 24175.730000000003 28187.68 26739.97 13202.96 25737.980000000003 True False 26886.296807384275 31622.390022928143 18647.24710178969 19673.655130889587 21941.351774314542 23932.544106006553 26061.460603568645 26030.73913193625 22404.4588139547 29041.700442155565 0.9257824575711618 1.0888615177996455 0.6420852366730643 0.6774277962846912 0.7555119514443276 0.8240751657663681 0.8973806700980586 0.8963228301243427 0.7714582298160972 1.0 14.82583830766423 -10.547377331261533 13.43212722522762 0.9999998160572545 0.8299524204034251 0.14403104669795552 0.12358165415637447 0.0 0.0 0.12937812321845132 0.0313788039808148 2.83545440925926e-11 10.547377331261533 -0.17004739565382943 EELMSS(ph)DLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R2 12 EELMSSDLEETAGSTSIPK 19 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EELMS(0.018)S(0.982)DLEETAGSTSIPK;EELMS(0.013)S(0.987)DLEETAGSTSIPK;EELMS(0.185)S(0.815)DLEETAGSTSIPK;EELMS(0.082)S(0.918)DLEETAGSTSIPK;EELMS(0.16)S(0.84)DLEETAGSTSIPK;EELMS(0.092)S(0.582)DLEET(0.324)AGS(0.001)TSIPK;EELMS(0.064)S(0.936)DLEETAGSTSIPK;EELMS(0.064)S(0.936)DLEETAGSTSIPK;EELMS(0.058)S(0.942)DLEETAGSTSIPK;EELMS(0.228)S(0.772)DLEETAGSTSIPK;EELMS(0.099)S(0.901)DLEETAGSTSIPK;EELMS(0.164)S(0.836)DLEETAGSTSIPK 205.78 9.5094e-22 41455200.0 275570.5 203390.30000000002 229366.6 237162.2 274427.3 215009.69999999998 259452.8 267630.39999999997 226900.4 224166.7 True False 260255.39480611493 218989.68200710858 214609.40267147237 204860.29923238515 239951.28916281046 244625.3345112728 271517.86929596995 268409.16015540244 272286.8201268819 217694.42491596713 1.195507854216188 1.0059498863677443 0.9858286575520452 0.9410452257170292 1.1022390180889325 1.1237096889628724 1.2472430995914543 1.2329629491385086 1.250775348206497 1.0 17.73194493548118 -6.788774801205534 2.281971436462717 1.1996612044157506 1.028339265417222 0.319009865491368 0.0934367605343111 0.30331246033434067 3.24164513521094 0.036069348274391955 0.032709705732849606 1.6263918853850583e-07 6.788774801205534 -0.17132193899852854 EELMSS(ph)DLEETAGSTSIPKR ddPTM_A459_Selumetinib_30min_R1 2 EELMSSDLEETAGSTSIPKR 20 1 O00567 O00567 NOP56 Nucleolar protein 56 1 EELMS(0.239)S(0.761)DLEETAGSTSIPKR;EELMS(0.22)S(0.78)DLEETAGSTSIPKR 193.76 8.4909e-16 69866000.0 4955.5 4872.9 8146.099999999999 7832.7 6664.7 5828.5 5554.2 5741.400000000001 2970.99 3646.17 True False 5070.953508275539 4302.378602650249 7039.904363324333 6464.865982988855 6061.879061748354 5769.87058185458 5135.242222287924 5589.119421304467 5041.553037475788 4114.191436203402 1.2325516658396047 1.0457409844352084 1.711127076240476 1.5713576004510543 1.4734071459111022 1.4024312362039837 1.2481777530086817 1.358497655729442 1.2254055543239768 1.0 12.006393209695492 -8.628004611357252 0.8380042710711467 1.0010714037815427 1.40545105803784 0.32334980971759686 0.17388954985950053 1.0018350110747523 1.5213901823881053 0.1836459416243752 0.06507404760780984 2.35502427801546e-09 8.628004611357252 0.4043796542562974 EELQANGSAPAADKEEPAAAGS(ph)GAASPSAAEK ddPTM_A459_Selumetinib_30min_R2 3 EELQANGSAPAADKEEPAAAGSGAASPSAAEK 32 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 EELQANGS(0.001)APAADKEEPAAAGS(0.444)GAAS(0.443)PS(0.112)AAEK;EELQANGSAPAADKEEPAAAGS(0.89)GAAS(0.093)PS(0.016)AAEK;EELQANGSAPAADKEEPAAAGS(0.89)GAAS(0.107)PS(0.003)AAEK 118.41 7.481600000000001e-17 48902000.0 162097.0 100488.0 130071.0 146513.0 142682.0 127135.0 198170.0 184924.0 146438.0 122268.0 True False 153088.29766570393 108195.10648015316 121702.37347059693 126557.67665097768 124757.01156673579 144646.69223337696 207385.2976664056 185462.09822418384 175729.6918195837 118737.80514958492 1.2892970143152347 0.9112102614988532 1.0249673498451253 1.0658583127045456 1.0506932599062946 1.2182025097327025 1.7465818692297983 1.5619464920253512 1.4799809681356402 1.0 16.857419824902323 -7.036497334916778 5.622984203521333 1.4951154049054565 1.0628762721708718 0.4425214697713945 0.19734774619823012 0.15361261878906926 13.286922731222225 0.07152964154975826 0.05685011853003358 9.19396116735319e-08 7.036497334916778 -0.4322391327345847 EELRHT(ph)PELPLAPR ddPTM_A459_Selumetinib_30min_R2 1 EELRHTPELPLAPR 14 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 EELRHT(1)PELPLAPR 72.681 0.029039 4411700.0 24000.0 17739.0 18857.0 20638.0 28183.0 21493.0 22384.0 21042.0 19250.0 15443.0 True False 22666.176079612167 19099.524260124974 17643.761149949223 17827.06879746424 24642.39958078328 24453.46565597176 23424.900353054556 21103.22873630939 23100.537889939722 14997.120464267316 1.511368541288804 1.2735460987749077 1.1764765904220007 1.1886994466664225 1.6431420711394 1.6305440577233126 1.5619598714878349 1.4071520453936945 1.5403315553128951 1.0 13.872397900889247 -4.448451030039281 18.56259084020814 1.401718711972201 4.15136296799966 0.025676024958998456 0.20723993605770813 347.69749975697454 92210.7147575953 0.052363393746244366 2485.0605229670728 3.560811385919283e-05 4.448451030039281 2.7496442560274588 EELS(ph)HSPEPCTK ddPTM_A459_Selumetinib_30min_R1 1 EELSHSPEPCTK 12 0 P41229-4;P41229-3;P41229-2;P41229-5;P41229 P41229-4 KDM5C Lysine-specific demethylase 5C 1 EELS(0.5)HS(0.5)PEPCTK 184.34 0.00010441 7607200.0 2347.8 2967.9 2368.0 2335.0 2175.6 2190.5 2591.2 2298.2 1233.4 1683.6 True False 2402.4991719764535 2620.4168882607214 2046.438606492924 1927.2360833785256 1978.817364133376 2168.4655588148685 2395.7436978129117 2237.2442703943134 2092.9897160282035 1899.7064596527443 1.2646686332874906 1.3793798904804055 1.0772393787969756 1.0144915145105173 1.0416437518958022 1.1414740144702418 1.261112571176307 1.177678929829648 1.1017437485635493 1.0 10.891560796944562 -5.265475550853394 24.993436571511303 1.1100911571419956 1.3220242687550163 0.5537527937978769 0.07876111076159749 257.763510899942 1596175.6798329982 0.022593943972522026 0.049908708205250736 5.426557999505486e-06 5.265475550853394 0.21193311161302075 EELSHS(ph)PEPCTK ddPTM_A459_Selumetinib_30min_R1 1 EELSHSPEPCTK 12 0 P41229-4;P41229-3;P41229-2;P41229-5;P41229 P41229-4 KDM5C Lysine-specific demethylase 5C 1 EELS(0.207)HS(0.771)PEPCT(0.023)K 120.59 0.0039949 8385200.0 3905.4 4523.9 3874.4 3908.2 4519.1 3422.4 4213.9 3939.7 2331.8 3407.0 True False 3996.388221414446 3994.239684895949 3348.277760555821 3225.7062359999777 4110.348202911906 3387.973763290573 3896.042130369644 3835.206358050855 3956.8942920662926 3844.321636990318 1.0395561554894193 1.0389972697557637 0.870967124170483 0.8390833391675707 1.0691998721859957 0.8812930038660826 1.013453737294421 0.9976288979434617 1.029282839914536 1.0 11.908513329587215 -7.401240475757976 18.080020735533733 1.0099427738336297 0.9554191242872546 0.1133458251895223 0.07335572222469358 5.96540840194379 859.212117284913 0.03194154330946988 0.02153465393591522 3.969716790734087e-08 7.401240475757976 -0.05452364954637512 EELSSGDSLS(ph)PDPWKR ddPTM_A459_Selumetinib_30min_R1 2 EELSSGDSLSPDPWKR 16 1 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 EELS(0.003)S(0.04)GDS(0.349)LS(0.608)PDPWKR;EELS(0.031)S(0.031)GDS(0.107)LS(0.831)PDPWKR 80.541 0.011794 10835000.0 5023.299999999999 6066.2 6109.8 5869.8 5812.2 4899.6 6541.299999999999 6367.1 3069.7 5466.0 True False 5140.333116359702 5355.9664839001325 5280.122718729085 4844.749619792404 5286.487536227253 4850.31447248086 6047.884474569155 6198.223824744426 5209.056697982632 6167.614343348719 0.8334394516581832 0.8684016518763233 0.8561045527146615 0.7855143577544016 0.8571365266909579 0.7864166276400758 0.9805873288901918 1.004962936995034 0.8445821038729805 1.0 12.590496842014076 -7.268236982977357 24.918272797390586 0.9579466763941564 0.8330998445275494 0.6133869915169758 0.049132630822458716 357.32963021869546 1309872.0933360322 0.019701763687485465 0.013618136755017187 5.392163061887308e-08 7.268236982977357 -0.12484683186660706 EELSSGDSLS(ph)PDPWKR ddPTM_A459_Selumetinib_30min_R2 1 EELSSGDSLSPDPWKR 16 1 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 EELS(0.014)S(0.011)GDS(0.019)LS(0.956)PDPWKR 91.622 0.0058702 7831500.0 46511.0 36444.0 46894.0 40854.0 48257.0 29973.0 35579.0 34628.0 28350.0 39590.0 True False 43926.10481828507 39239.13761407037 43876.89109432672 35289.61472291906 42194.52423694633 34101.50868219613 37233.493998451006 34728.761747025994 34020.792165183935 38446.93383282674 1.1425125605407864 1.0206051224965886 1.1412325176595428 0.9178785199455386 1.0974743635061952 0.886976028582014 0.9684385797928137 0.9032908033195068 0.8848766019446866 1.0 15.230580926486592 -6.081765640567962 0.7245279698803655 0.9218592197654633 1.1135109471342808 0.4514325809855224 0.07149051797317522 0.7318421373476675 0.7798308056029645 0.03798979185116883 0.0865865710755844 8.283890688120721e-07 6.081765640567962 0.19165172736881753 EELTPGAPQHQLPPVPGS(ph)PEPYPGQQAPGPEPSQPLLELTPR ddPTM_A459_Selumetinib_30min_R1 2 EELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLELTPR 42 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 EELTPGAPQHQLPPVPGS(0.953)PEPY(0.047)PGQQAPGPEPSQPLLELTPR;EELTPGAPQHQLPPVPGS(0.952)PEPY(0.048)PGQQAPGPEPSQPLLELTPR 122.9 3.2706e-30 10595600.0 2004.19 2299.57 1416.34 1538.8400000000001 1579.84 1641.08 1802.8000000000002 1926.98 986.62 1863.75 True False 2050.8837275251244 2030.3352753589108 1224.0088073987292 1270.1104816043733 1436.9437509434053 1624.5722251814207 1666.8133445573928 1875.8702306868151 1674.2220801262745 2102.9804669623436 0.9752271881476529 0.9654560787678806 0.5820352716669558 0.6039573365315124 0.6832891572307388 0.7725094220813372 0.7925957329337568 0.8920055417330726 0.7961187022077335 1.0 11.038219734661673 -8.6382313434073 0.7913926898551493 0.9940352558934532 0.7582776737727603 0.21247715686013657 0.12753450824837548 1.3663487532694207 1.853538634550609 0.13879878198087794 0.05040113128706657 2.3002161937099484e-09 8.6382313434073 -0.23575758212069287 EELTPGAPQHQLPPVPGS(ph)PEPYPGQQAPGPEPSQPLLELTPR ddPTM_A459_Selumetinib_30min_R2 2 EELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLELTPR 42 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 EELTPGAPQHQLPPVPGS(0.951)PEPY(0.049)PGQQAPGPEPSQPLLELTPR;EELTPGAPQHQLPPVPGS(0.942)PEPY(0.058)PGQQAPGPEPSQPLLELTPR 105.67 1.1213e-22 7003000.0 26498.0 19285.6 24363.0 25323.0 28006.0 24408.0 29414.0 28033.0 30685.0 22360.0 True False 25025.34723989848 20764.743507022173 22795.511104428755 21873.96371538844 24487.635903183345 27769.980446236397 30781.809282735267 28114.57138888703 36822.85741053508 21714.408701743007 1.152476569066774 0.956265666370892 1.049787328659747 1.0073478866423209 1.1277136872355973 1.278873435038888 1.417575293232112 1.2947426648845513 1.6957798812904965 1.0 14.406365047299685 -6.769400762360737 2.130646429312061 1.3768573697855842 1.0362780782917518 0.42175473921468143 0.16570710254778306 0.2703689158103544 2.5241558973345732 0.06166517909659875 0.05646767093631292 1.7005884990076195e-07 6.769400762360737 -0.34057929149383237 EEMMRTLNK ddPTM_A459_Selumetinib_30min_R2 1 EEMMRTLNK 9 1 A0A0J9YYF7;Q86T65-4;Q86T65 A0A0J9YYF7 DAAM2 Disheveled-associated activator of morphogenesis 2 0 104.45 0.030216000000000007 0.0 17856.0 17092.0 21097.0 19668.0 14947.0 15911.0 16846.0 16473.0 11005.0 13942.0 False True 16863.635003231448 18402.90144055788 19739.641988676824 16989.18447080756 13069.2242321246 18102.59582432266 17629.37237971573 16520.933702748054 13206.30750539151 13539.458234333671 1.245517709155323 1.3592051559265035 1.4579344052792735 1.2547905667101207 0.9652693635099341 1.3370251239756166 1.3020736926541683 1.220206408322446 0.9753940871801392 1.0 13.724882391853985 -7.962202964210857 0.3032883966471914 0.9548804931753581 1.3644165088960336 0.3805746342640084 0.12949577192001346 1.8093868164800875 0.5971077549715077 0.26781786204111546 0.24638048772235804 1.0909303793107803e-08 7.962202964210857 0.40953601572067555 EENISAPLISS(ph)SPVK ddPTM_A459_Selumetinib_30min_R1 1 EENISAPLISSSPVK 15 0 A2A2Y4-4;A2A2Y4-3;A2A2Y4-5;A2A2Y4-2;A2A2Y4 A2A2Y4-4 FRMD3 FERM domain-containing protein 3 1 EENISAPLISS(0.994)S(0.006)PVK 271.41 5.201e-45 3870900.0 2181.2 2799.7 3054.6 2413.7 3160.4 2978.6 2957.3 3241.5 1320.5 2761.0 True False 2232.017716123621 2471.9098224547815 2639.80209771676 1992.1926057604906 2874.5423780139377 2948.637988352416 2734.228480064111 3155.524890124086 2240.792054495902 3115.4012444174527 0.7164463069157517 0.7934483004024744 0.847339360362352 0.6394658181928696 0.9226876901217412 0.9464713393294482 0.8776489015543751 1.0128791261730834 0.7192627461747408 1.0 11.605202270078937 -6.293598479265307 24.427215556557357 0.9136924722991038 0.7593490600495604 0.4368438413987197 0.09091870303012713 478.3044384745195 363306.1674652235 0.0267794583850762 0.03036782369153644 5.086294713309743e-07 6.293598479265307 -0.1543434122495434 EENISAPLISS(ph)SPVK ddPTM_A459_Selumetinib_30min_R2 1 EENISAPLISSSPVK 15 0 A2A2Y4-4;A2A2Y4-3;A2A2Y4-5;A2A2Y4-2;A2A2Y4 A2A2Y4-4 FRMD3 FERM domain-containing protein 3 1 EENISAPLIS(0.211)S(0.693)S(0.096)PVK 132.23 0.0006422000000000001 9903300.0 98816.0 29975.0 74973.0 83665.0 43478.0 45578.0 128070.0 75569.0 80308.0 57643.0 True False 93324.20231178979 32273.986115183845 70149.31880443041 72269.68266982498 38015.90494174838 51855.95578411021 134025.5087658907 75788.8932788786 96371.84399300156 55978.69681549968 1.6671378152902925 0.5765405047129938 1.253143120420179 1.2910211702144263 0.6791137897876596 0.9263516075592537 2.3942234526756794 1.3538881322777376 1.7215806990047258 1.0 15.77259028089936 EENISAPLISSS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 EENISAPLISSSPVK 15 0 A2A2Y4-4;A2A2Y4-3;A2A2Y4-5;A2A2Y4-2;A2A2Y4 A2A2Y4-4 FRMD3 FERM domain-containing protein 3 1 EENISAPLISS(0.085)S(0.915)PVK 206.67 1.9973e-06 3737500.0 2602.4 3662.5 3581.0 3121.3 3090.3 3522.4 3252.6 3708.5 1759.6 3540.0 True False 2663.0308566110916 3233.692797349942 3094.7198690249857 2576.2235490575536 2810.7829106367776 3486.967854083308 3007.253763316717 3610.1385330942985 2985.912683900783 3994.3934825200263 0.6666921694782583 0.8095578994660874 0.7747659018992178 0.6449598819774355 0.703682029058259 0.8729655376573997 0.7528686836879847 0.9038014278995606 0.7475259252668813 1.0 11.96376074246123 -11.037405556760485 0.1783774227881207 1.2541421226213134 0.6847457200274986 0.532639748066245 0.07214560222654832 23.299553327710463 0.7258495649256007 2.903876286094256 0.28688081346931604 9.174754312034546e-12 11.037405556760485 -0.5693964025938149 EENISAPLISSS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 EENISAPLISSSPVK 15 0 A2A2Y4-4;A2A2Y4-3;A2A2Y4-5;A2A2Y4-2;A2A2Y4 A2A2Y4-4 FRMD3 FERM domain-containing protein 3 1 EENISAPLISS(0.031)S(0.969)PVK 216.77 3.4502e-09 9621400.0 104610.0 27571.0 78396.0 94717.0 46519.0 52089.0 144940.0 80255.0 70424.0 59350.0 True False 98796.19498700957 29685.60704526217 73352.08671111095 81816.38120406124 40674.867334863426 59263.78693313696 151679.99719316134 80488.52876306955 84510.76781096717 57636.411290181015 1.7141281487773783 0.515049538664102 1.2726692219230393 1.4195259450166278 0.7057147803682362 1.0282352007442417 2.6316696997233358 1.3964875147731768 1.4662739389772605 1.0 15.814692888985764 EENMDTS(ph)NTSISK ddPTM_A459_Selumetinib_30min_R2 1 EENMDTSNTSISK 13 0 Q4G0J3;Q4G0J3-3;H0YA82;D6RFF0 Q4G0J3 LARP7 La-related protein 7 1 EENMDT(0.428)S(0.556)NT(0.013)S(0.003)ISK 95.854 0.018632 0.0 17085.0 15029.0 16170.0 18482.0 16573.0 15188.0 17582.0 16294.0 13212.0 15854.0 True False 16135.484096673918 16181.675974148382 15129.639804564828 15964.719716771684 14490.951575500163 17280.009137063193 18399.59783807206 16341.412842383095 15854.769174123821 15396.253826361071 1.0480136453094295 1.051013847696024 0.9826831887286923 1.0369223511655348 0.9411998359425022 1.1223515364157484 1.1950697907155012 1.0613888954210242 1.0297809683403434 1.0 13.91029174062597 -6.7827181653019215 24.99999309094934 1.0926395219803828 1.013895413753492 0.25234430413087605 0.05849409107346381 318.02917154539034 373643.2183069428 0.02117190120904247 0.01869064177275547 1.6492323109540632e-07 6.7827181653019215 -0.07874410822689093 EENPES(ph)DGEPVVEDGTSVK ddPTM_A459_Selumetinib_30min_R1 2 EENPESDGEPVVEDGTSVK 19 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;H0Y6I0;A0A087WTW2 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 EENPES(1)DGEPVVEDGTSVK;EENPES(0.998)DGEPVVEDGT(0.002)SVK 271.58 8.850299999999998e-59 23294000.0 10415.3 11483.7 7081.3 6829.799999999999 9067.8 7894.6 10923.1 10796.900000000001 6057.1 10298.2 True False 10657.9562253541 10139.18306537271 6119.698354796601 5637.103641224257 8247.619091050115 7815.187491723286 10099.161772761743 10510.531138726126 10278.45630691944 11620.07428296264 0.9172020733964501 0.8725575085383737 0.526648815297963 0.4851176940830217 0.709773353440845 0.6725591679893062 0.8691133573534155 0.9045149697654407 0.8845430809327716 1.0 13.504331670952759 -7.358751478658637 3.3676975914793568 0.9172017542829328 0.6876905757189136 0.4122707197045644 0.12773317327779732 0.2944478947242985 6.320730557114987 0.06526580718146911 0.04204511859034369 4.377725451289465e-08 7.358751478658637 -0.22951117856401926 EENPES(ph)DGEPVVEDGTSVK ddPTM_A459_Selumetinib_30min_R2 2 EENPESDGEPVVEDGTSVK 19 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;H0Y6I0;A0A087WTW2 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 EENPES(0.999)DGEPVVEDGTSVK;EENPES(1)DGEPVVEDGTSVK 194.15 3.2521e-15 63347000.0 164715.0 130564.0 148744.0 179131.0 181064.0 142049.0 193548.0 192260.0 159899.0 144682.0 True False 155560.79970638824 140577.83897057062 139173.9729802219 154733.04878178917 158317.12158730233 161614.96035756453 202548.3655080863 192819.44476964336 191883.26795134888 140504.6547310192 1.1071576240957453 1.000520867011072 0.990529269273358 1.101266353616602 1.1267749235097098 1.1502463079743424 1.441577618163918 1.3723349246953784 1.3656719652362295 1.0 17.100258400229073 -6.9559657929393675 2.5477402672737557 1.3246478509508584 1.0556078297769103 0.4352011179486992 0.1196690058677466 0.22783028313625275 2.9948809743154245 0.046710275561159295 0.038381991550640475 1.1067109502652547e-07 6.9559657929393675 -0.2690400211739481 EEPDSENIPQELLSNLGHPES(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 EEPDSENIPQELLSNLGHPESPPR 24 0 D6RF40;D6RAG5;D6R9R7;A0A0A0MTL5;Q13309-2;Q13309 D6RF40 SKP2 S-phase kinase-associated protein 2 1 EEPDSENIPQELLSNLGHPES(1)PPR;EEPDSENIPQELLS(0.011)NLGHPES(0.989)PPR;EEPDSENIPQELLSNLGHPES(1)PPR;EEPDSENIPQELLSNLGHPES(1)PPR 215.06 7.913399999999999e-33 46893800.0 6704.52 7146.740000000001 4474.45 3909.79 5886.57 4773.17 6455.02 6229.83 2600.82 5244.03 True False 6860.722271275053 6309.996358370711 3866.844266394538 3227.0185723479744 5354.130782858347 4725.156243491605 5968.112644433586 6064.59467106023 4413.40158362289 5917.152331677823 1.1594635200695733 1.066390723894292 0.653497501778543 0.5453668236783327 0.9048492387452479 0.7985524080891416 1.0086123036723162 1.0249177866510324 0.7458658043997761 1.0 12.53068732109314 -10.379007389653047 14.02884317244474 1.000010064348955 0.8742569137218981 0.03717290748904123 0.1841366415530456 0.0 0.0 0.19194617865506214 0.04655378641344114 4.178232571960012e-11 10.379007389653047 -0.12575315062705683 EEPDSENIPQELLSNLGHPES(ph)PPR ddPTM_A459_Selumetinib_30min_R2 4 EEPDSENIPQELLSNLGHPESPPR 24 0 D6RF40;D6RAG5;D6R9R7;A0A0A0MTL5;Q13309-2;Q13309 D6RF40 SKP2 S-phase kinase-associated protein 2 1 EEPDS(0.001)ENIPQELLS(0.01)NLGHPES(0.99)PPR;EEPDSENIPQELLS(0.004)NLGHPES(0.996)PPR;EEPDSENIPQELLS(0.013)NLGHPES(0.987)PPR;EEPDSENIPQELLS(0.007)NLGHPES(0.993)PPR 129.93 7.8902e-08 29929300.0 29143.300000000003 22515.300000000003 29277.5 36826.0 41077.3 29565.8 35001.8 39749.5 37884.8 31689.5 True False 27523.632055873382 24242.15111189989 27393.817524931772 31810.235271606638 35916.80233827869 33638.22057838972 36629.45305475093 39865.16446411604 45462.8185897552 30774.541795790938 0.8943636671671847 0.7877339416704333 0.890145423015801 1.033654228962634 1.1670946257010093 1.0930534986223728 1.1902517768683976 1.2953942492027106 1.4772866121429367 1.0 14.909449756036231 -6.145114179712514 0.8363157662157618 1.2605966389184438 0.806376209807649 0.63235042829074 0.11951715472239598 0.4173533233541347 0.6117939447165547 0.06069026174904438 0.11819694108572557 7.159551547683677e-07 6.145114179712514 -0.45422042911079474 EEPEALY(ph)AAVNK ddPTM_A459_Selumetinib_30min_R2 1 EEPEALYAAVNK 12 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 1 EEPEALY(1)AAVNK 169.65 7.2487e-05 0.0 9358.0 8112.5 9629.2 9139.1 9453.4 11399.0 9820.2 8553.7 7990.2 9324.2 True False 8837.91982304211 8734.702664201126 9009.667755480254 7894.338814173146 8265.779377531717 12969.10878018063 10276.858758357148 8578.589850858738 9588.463264841372 9054.986118818975 0.9760279813874329 0.9646290507334734 0.9949952034443723 0.8718222988510543 0.9128428546514223 1.4322615860478167 1.134939206256623 0.9473885148238778 1.0589152914231057 1.0 13.144496714205683 EEPGS(ph)PLSPAPR ddPTM_A459_Selumetinib_30min_R1 2 EEPGSPLSPAPR 12 0 B2RBV5 B2RBV5 LOC93622 1 EEPGS(0.999)PLS(0.001)PAPR;EEPGS(0.999)PLS(0.001)PAPR 122.52 0.0035218000000000007 26901000.0 7018.6 8240.6 8485.8 8635.5 8378.3 7225.4 8514.5 7758.3 4075.2 6573.5 True False 7182.119724181754 7275.786721048999 7333.474969162867 7127.472033411244 7620.48424430901 7152.7190361383 7872.244409936727 7552.5246814899565 6915.316759168268 7417.272756312256 0.9682965639991623 0.9809247900257073 0.9887023452011959 0.9609289381121403 1.0273970628657032 0.9643327502081118 1.0613394799641527 1.0182347244898873 0.9323260700212469 1.0 12.856673107060125 -6.24840177927588 24.70586426842132 1.0027398619870767 0.9761560759195205 0.12320194589768219 0.03346115164221098 1464.7159041455175 2775590.7327037463 0.009870991239666218 0.012647199458707894 5.64414575801074e-07 6.24840177927588 -0.02658378606755618 EEPGS(ph)PLSPAPR ddPTM_A459_Selumetinib_30min_R2 2 EEPGSPLSPAPR 12 0 B2RBV5 B2RBV5 LOC93622 1 EEPGS(1)PLSPAPR;EEPGS(0.999)PLS(0.001)PAPR 107.39 0.008628 6626500.0 77156.0 62275.0 86670.0 85684.0 83029.0 56375.0 55534.0 57689.0 56512.0 72481.0 True False 72867.97839993994 67051.2922543144 81093.74655916086 74013.69138685556 72598.15473132221 64140.14452870273 58116.441038533354 57856.86543907194 67815.97907720905 70388.2852017456 1.0352287769347852 0.9525916430856813 1.1520915210071032 1.051505817689959 1.0313954164850403 0.9112332307125459 0.825655020177876 0.8219672531195164 0.9634554795991427 1.0 16.10304771909832 -6.776558268714717 3.8814435594470718 0.8855799801491789 1.0477159944795196 0.5058932165693412 0.06853799733588498 0.16852479802928336 5.55103248932934 0.024607415329707262 0.02273301713578041 1.6727911851668028e-07 6.776558268714717 0.16213601433034064 EEPLS(ph)EEEPCTSTAIAS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 EEPLSEEEPCTSTAIASPEK 20 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 EEPLS(1)EEEPCTSTAIAS(1)PEK;EEPLS(1)EEEPCT(0.001)S(0.002)T(0.009)AIAS(0.988)PEK 151.75 4.2105e-05 16782200.0 4437.92 5720.099999999999 4338.75 4012.54 4358.32 4285.85 4968.2 5265.78 3055.76 4981.0 True False 4541.314901310904 5050.388032797654 3749.571581047796 3311.825213704355 3964.1107255238926 4242.73824024045 4593.444674079231 5126.114408735959 5185.40153611995 5620.359869048658 0.8080114097888894 0.898588017576981 0.6671408358914347 0.589255010509663 0.7053126166091721 0.754887291756036 0.8172865761453012 0.9120615989316787 0.9226102343865871 1.0 12.456446793163456 -7.710959720872783 1.4469082025920559 0.9677012925979203 0.7311099051768386 0.5910992306385523 0.07836234110499736 0.34745781244762364 1.3630601980601806 0.07017389128728728 0.028329482514926247 1.9455405145852292e-08 7.710959720872783 -0.23659138742108166 EEPLS(ph)EEEPCTSTAIAS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 EEPLSEEEPCTSTAIASPEK 20 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 EEPLS(1)EEEPCTST(0.001)AIAS(0.999)PEK;EEPLS(1)EEEPCTSTAIAS(1)PEK 96.38 0.0039902 14574800.0 72292.0 51061.0 61173.0 57334.0 57076.0 54558.0 72832.0 79005.0 52116.0 48768.0 True False 68274.30004780505 54977.214513007566 57237.19578012646 49525.010293333384 49905.602614086 62072.869271786556 76218.83231387011 79234.89147001808 62540.65624270642 47359.94112551891 1.4416044113495925 1.1608378981574419 1.2085571565308681 1.045715199731274 1.0537513651425425 1.3106618757669843 1.6093523450940523 1.673036105767539 1.320539146722201 1.0 15.531379667062454 -7.003681071242458 9.335698336529259 1.4574217714298765 1.1753822188535263 0.18982064669997245 0.20033507258681013 0.14482074392236277 182.64333031863856 0.07154999822094742 0.06007630587703928 9.915598400731942e-08 7.003681071242458 -0.28203955257635016 EEPLS(ph)EEEPCTSTAIAS(ph)PEKK ddPTM_A459_Selumetinib_30min_R1 3 EEPLSEEEPCTSTAIASPEKK 21 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 EEPLS(0.998)EEEPCT(0.009)S(0.082)T(0.093)AIAS(0.818)PEKK;EEPLS(0.993)EEEPCT(0.005)S(0.002)T(0.015)AIAS(0.985)PEKK;EEPLS(1)EEEPCTST(0.003)AIAS(0.996)PEKK 115.7 0.00018864 204039200.0 8342.2 10865.51 7751.43 7836.14 6985.51 7669.24 7820.889999999999 8931.59 5128.1900000000005 8715.96 True False 8536.557028904494 9593.371037961442 6698.8283815572 6467.705251565654 6353.671853891962 7592.094408712774 7230.953970665335 8694.695219306921 8702.16388182153 9834.738366639891 0.8680004196004931 0.9754576766884635 0.6811394601284043 0.6576387709005616 0.6460438109308585 0.7719670951761849 0.7352461957903454 0.8840799719492208 0.8848393884416762 1.0 13.26367095768731 -8.220340254905954 1.395827333170578 0.9860643220750182 0.7590261528604497 0.377162085016867 0.09719108666204503 0.479617077204079 1.7728736564176262 0.10173335241403884 0.03193414400971001 6.020876860843627e-09 8.220340254905954 -0.22703816921456843 EEPLS(ph)EEEPCTSTAIAS(ph)PEKK ddPTM_A459_Selumetinib_30min_R2 3 EEPLSEEEPCTSTAIASPEKK 21 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 EEPLS(1)EEEPCTSTAIAS(1)PEKK;EEPLS(1)EEEPCTS(0.003)T(0.027)AIAS(0.97)PEKK;EEPLS(0.999)EEEPCT(0.001)STAIAS(0.999)PEKK 86.89 0.0024395 329754000.0 298882.0 210144.0 219726.0 227717.0 195707.0 199689.0 306569.0 292514.0 194394.0 203100.0 True False 282271.33495944325 226261.3690805402 205589.06837958048 196701.55176626382 171120.5370172212 227194.34715374056 320825.06595494866 293365.1673117001 233278.23182217818 197235.97528282675 1.4311351392902838 1.1471607487229065 1.0423507581959923 0.99729043590655 0.867592926553296 1.151891011910758 1.6266052148696564 1.487381634567572 1.1827367268454378 1.0 17.58956319364001 -7.0202339063878965 24.612030381883432 1.368289225387808 1.0831437919172693 0.1997416895990659 0.20776670332399988 831.8256752978499 1011810.228575004 0.07982401801403585 0.06267457077849685 9.544783756604313e-08 7.0202339063878965 -0.2851454334705388 EEPLS(ph)EEEPCTSTAIASPEKK ddPTM_A459_Selumetinib_30min_R2 2 EEPLSEEEPCTSTAIASPEKK 21 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 EEPLS(1)EEEPCTSTAIASPEKK;EEPLS(1)EEEPCTSTAIASPEKK 135.68 1.8417e-05 162560000.0 277220.0 174017.0 250215.0 230748.0 225684.0 181953.0 245520.0 263498.0 187796.0 188851.0 True False 261813.22219958683 187363.54434715456 234116.43931349352 199319.72433749776 197331.55827944135 207015.37414511867 256937.16648865043 264264.7355555582 225360.44745865546 183398.38093617483 1.427565613519246 1.0216204929985704 1.2765458349109924 1.0868128896234028 1.0759721938227769 1.1287742731881742 1.400978379291517 1.4409327618193422 1.2288028188050582 1.0 17.48462137713389 -7.244021976322851 24.3949812701386 1.3044228943717022 1.1596738706324818 0.06555611192945165 0.1562379178661393 1069.2808825623815 1497646.1615948344 0.05709441931862613 0.04410882186675542 5.7013542135671646e-08 7.244021976322851 -0.14474902373922038 EEPLSEEEPCT(ph)STAIASPEKK ddPTM_A459_Selumetinib_30min_R2 1 EEPLSEEEPCTSTAIASPEKK 21 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 EEPLSEEEPCT(0.406)S(0.014)T(0.196)AIAS(0.385)PEKK 110.91 0.00013189 15233000.0 29479.0 17530.0 19955.0 24072.0 16977.0 18357.0 25317.0 21140.0 16083.0 17906.0 True False 27840.675193786952 18874.494632165894 18671.11702536125 20793.352073483824 14844.197483694334 20885.510121745385 26494.290664683784 21201.51390008461 19300.049396566254 17389.00725462479 1.601050294943228 1.0854268076256062 1.0737310504252893 1.1957756856966986 0.8536541083877208 1.2010754734828615 1.5236229576957216 1.2192480910286494 1.109899438993747 1.0 14.085887950508374 -14.522531364562758 0.018356660102162647 2.7918538056753584e-06 2.0439232681845616 0.07859668273433384 0.20615315465750142 17199.10598298244 23.83137866836072 1746.825954407915 1002.2052019632414 3.0024005809384218e-15 14.522531364562758 2.043920476330756 EEPLSEEEPCTSTAIAS(ph)PEKK ddPTM_A459_Selumetinib_30min_R1 3 EEPLSEEEPCTSTAIASPEKK 21 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 EEPLSEEEPCT(0.155)S(0.125)T(0.032)AIAS(0.687)PEKK;EEPLSEEEPCTS(0.002)T(0.005)AIAS(0.993)PEKK;EEPLSEEEPCT(0.015)S(0.036)T(0.113)AIAS(0.835)PEKK 124.51 3.6556e-05 30412800.0 7230.799999999999 8995.8 7692.84 6992.1 6054.500000000001 7209.7 7031.900000000001 7555.4 4553.92 8439.0 True False 7399.263571312435 7942.567553966042 6648.1945817453725 5771.060992972587 5506.871544008797 7137.176963883841 6501.478121584831 7355.00624860204 7727.669634842842 9522.22785282104 0.7770517242055219 0.8341081180506502 0.6981763810425717 0.6060620562931458 0.5783175564715498 0.7495280594204005 0.6827685938704683 0.7724039334369694 0.8115400885469732 1.0 13.217083435526725 -8.636956744609048 1.1664377594678756 0.9986274193312413 0.7012461068156858 0.6071886117114196 0.07200338465205147 0.4748984095667572 1.3597440017127522 0.07720149546414948 0.024119492617259215 2.3069769503789584e-09 8.636956744609048 -0.29738131251555555 EEPLSEEEPCTSTAIAS(ph)PEKK ddPTM_A459_Selumetinib_30min_R2 1 EEPLSEEEPCTSTAIASPEKK 21 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 EEPLSEEEPCTS(0.001)T(0.001)AIAS(0.997)PEKK 100.94 0.00013197 13974000.0 94216.0 62915.0 65163.0 75567.0 69125.0 61249.0 91693.0 82483.0 55983.0 57696.0 True False 88979.85189653074 67740.37819639001 60970.48352410996 65274.64423965393 60440.89951465933 69685.49378693593 95956.90618623262 82723.01187420433 67181.16429571401 56030.16656778914 1.5880704511002446 1.2089983368946986 1.0881724481461907 1.1649910795942429 1.0787206823940774 1.2437138430175043 1.712593627044413 1.4764013198875707 1.1990177508116744 1.0 15.773916161001475 -7.026123687978975 24.783877252260844 1.3997676373434143 1.2085727199222 0.04219329214258627 0.21934524100827574 1351.1006662916698 1281802.1945136033 0.08328587026881468 0.06476232152245551 9.41621382586772e-08 7.026123687978975 -0.1911949174212142 EEPPEPVPS(ph)PIIPILPSTAGK ddPTM_A459_Selumetinib_30min_R1 1 EEPPEPVPSPIIPILPSTAGK 21 0 Q8NEZ4;Q8NEZ4-3;H7BY37;Q8NEZ4-2;H0Y765;H7C2V8 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 1 EEPPEPVPS(1)PIIPILPSTAGK 90.778 0.00047045 2425600.0 1117.0 1110.7 977.86 929.49 991.62 893.72 1078.1 811.43 528.57 1119.4 True False 1143.0239266963526 980.6587276495784 845.0719830004942 767.1720201882254 901.92814608473 884.7299882328338 996.7780490167106 789.9082405038978 896.9446847746292 1263.0858938793554 0.9049455244771576 0.7763990813306056 0.6690534563765874 0.6073791370054699 0.7140671512961084 0.7004511668763356 0.7891609381807558 0.6253796707980229 0.7101216861980897 1.0 10.30273703499916 -10.195461475706 7.24088861615428 1.0000000000692377 0.7168460011612012 0.5083251197114538 0.08192215233391235 6.025740284246396e-11 0.0 0.08245693385609289 0.019998743991367057 6.375856358568664e-11 10.195461475706 -0.2831539989080365 EEPS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 EEPSPVK 7 0 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EEPS(1)PVK 92.838 0.026497000000000003 6295500.0 6072.4 7481.8 2258.0 2405.0 3351.6 3364.0 5048.0 5409.3 3161.3 6311.7 True False 6213.8751051664585 6605.827377805542 1951.3760023061761 1985.0118974412635 3048.448371773039 3330.1612142676154 4667.225295831885 5265.827792117292 5364.49520778333 7121.868176164308 0.8725063356217756 0.9275413717869887 0.2739977705340156 0.27872067389351063 0.4280405500870799 0.4675965816684312 0.6553372205697798 0.739388551130605 0.7532426991189463 1.0 12.798040016718845 -8.264420666271377 1.0623497266932551 0.977691225681897 0.5353320310214721 0.30821587652616234 0.20849959032127166 0.6644829590478903 1.5327872566824596 0.22093512341172838 0.07467058154421889 5.439754920955245e-09 8.264420666271377 -0.44235919466042495 EEPS(ph)PVKAEVAEK ddPTM_A459_Selumetinib_30min_R1 2 EEPSPVKAEVAEK 13 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EEPS(1)PVKAEVAEK;EEPS(1)PVKAEVAEK 115.8 0.019316 500590000.0 12575.0 13834.2 8225.4 7829.29 8817.6 9182.199999999999 11136.5 11144.1 6042.25 11034.7 True False 12867.973033309434 12214.485432654908 7108.435858888054 6462.051475475223 8020.049636873717 9089.835404770543 10296.464838952417 10848.522266861579 10253.256941520525 12451.111232080148 1.0334798873336901 0.9809956079409543 0.5709077468180711 0.5189939560435233 0.6441232021291521 0.7300421010897955 0.8269514782281996 0.8712894828945454 0.8234812741133598 1.0 13.603986884691775 -8.299756620505462 0.9360895834057326 0.9823701688299032 0.7404448047372287 0.17571157085381095 0.15574486483482558 1.0282668716143786 1.9162095296559833 0.16666153361049538 0.05901669128292354 5.014681786671261e-09 8.299756620505462 -0.2419253640926745 EEPS(ph)PVKAEVAEK ddPTM_A459_Selumetinib_30min_R2 2 EEPSPVKAEVAEK 13 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EEPS(1)PVKAEVAEK;EEPS(1)PVKAEVAEK 71.268 0.032105 669620000.0 247274.0 187022.0 211018.0 216766.0 209894.0 197383.0 310276.0 257861.0 209630.0 174773.0 True False 233531.5009962507 201365.98602948835 197441.33161902707 187242.09685779296 183525.2392438321 224570.71658552415 324704.44880023 258611.33281881316 251561.85755158743 169726.84937521143 1.3759255053393922 1.1864120896060055 1.163288733313772 1.1031966807081945 1.0812976256815847 1.323130178944585 1.913100078128552 1.5236913533173926 1.482157115845974 1.0 17.372855279721 -7.007050850174344 24.443791561999628 1.5369119520395853 1.1793843077232062 0.27399862603943537 0.22075490438378392 258.72839211235726 896957.9745137754 0.07666253121447825 0.06499344801462971 9.838958977418335e-08 7.007050850174344 -0.35752764431637907 EEPS(ph)QNDISPK ddPTM_A459_Selumetinib_30min_R2 1 EEPSQNDISPK 11 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 EEPS(0.686)QNDIS(0.314)PK 99.539 0.017157 24755000.0 161420.0 173240.0 181370.0 156250.0 133150.0 114240.0 136300.0 128770.0 84616.0 144960.0 True False 152448.9226154582 186526.95094560328 169700.85166072464 134968.48045371586 116422.50662389696 129975.52303253209 142638.22007332637 129144.69938097877 101541.56436857881 140774.6281486882 1.0829289668195 1.3250040394252778 1.2054789552097707 0.9587557234472691 0.827013419640717 0.9232879869179981 1.0132381235819696 0.9173861872650394 0.7213058610343416 1.0 17.10302781450273 -5.800760790294108 4.149116117213801 0.9026654347249985 1.2202440140903774 0.6708386597537546 0.09545973801208879 0.11690753178771887 4.307602733829079 0.02707505934598399 0.043534707614609994 1.5821192317065295e-06 5.800760790294108 0.3175785793653789 EEPSQNDIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 EEPSQNDISPK 11 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 EEPSQNDIS(1)PK;EEPSQNDIS(1)PK;EEPSQNDIS(1)PK;EEPS(0.004)QNDIS(0.996)PK 188.09 1.9423e-05 470568600.0 18573.7 18323.3 19567.399999999998 21291.899999999998 13120.2 15782.400000000001 12792.0 12937.5 9571.699999999999 13836.800000000001 True False 19006.43107187113 16177.999517728926 16910.25455603449 17573.66936346347 11933.480226559455 15623.643385272671 11827.089141101718 12594.355473077392 16242.475810691707 15612.888061845504 1.2173552386069242 1.036195190386616 1.0830958685574303 1.1255873541045673 0.764335219678048 1.0006888746902278 0.7575209079993692 0.8066640472402574 1.0403248743187226 1.0 13.930449810338157 -6.244427556462585 24.91055930557489 0.8836737801014621 1.1075708798549393 0.5223165754183093 0.10291809946476696 618.7067712665367 905977.5423222188 0.02937547438127944 0.03782137684862371 5.69603230243034e-07 6.244427556462585 0.22389709975347716 EEPSQNDIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 EEPSQNDISPK 11 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 EEPS(0.001)QNDIS(0.999)PK;EEPS(0.032)QNDIS(0.968)PK;EEPS(0.004)QNDIS(0.996)PK 164.93 0.00054838 493715000.0 734540.0 699010.0 620540.0 584380.0 528630.0 433970.0 561150.0 499480.0 333901.0 533090.0 True False 693717.2073965961 752621.8193285946 580615.1319928683 504786.43588827125 462218.7733878383 493745.4283125701 587244.5868976307 500933.404106635 400690.52997344127 517698.30656584067 1.3400028522372023 1.4537845880183045 1.1215318354900314 0.9750590826475356 0.8928342386398235 0.9537319748790326 1.1343374692359462 0.9676164626258565 0.7739846255851749 1.0 18.981752073468066 -5.462192942533442 2.8811276639280514 0.960605730416584 1.3983244592724988 0.7900639101376384 0.08968730240947395 0.11750210507567353 1.9010810140746093 0.025939005470997423 0.06040876805449798 3.4499043755577035e-06 5.462192942533442 0.4377187288559148 EEPVAIES(ph)PGQDLLGESR ddPTM_A459_Selumetinib_30min_R2 2 EEPVAIESPGQDLLGESR 18 0 Q96RG2-4;Q96RG2;Q96RG2-2 Q96RG2-4 PASK PAS domain-containing serine/threonine-protein kinase 1 EEPVAIES(1)PGQDLLGESR;EEPVAIES(1)PGQDLLGESR 171.85 2.5346999999999995e-09 0.0 14086.1 11110.4 15785.400000000001 17736.4 18503.1 12316.9 11360.0 13146.1 12144.3 15205.7 True False 13303.250953126038 11962.531954433312 14769.784549844024 15320.671723003416 16178.575158187234 14013.441173314039 11888.262509412962 13184.352974545991 14573.499340093229 14766.671931846762 0.9008970345197 0.8101034552432996 1.0002107866966659 1.0375169025027136 1.0956141798813495 0.9489911632079902 0.8050739235137989 0.8928452555454801 0.9869183393086072 1.0 13.850057092013634 -5.265320830321761 24.911935246415897 0.9671983250647803 0.855500243464916 0.2602325540573658 0.0776246927021 462.5425776361484 2968711.708543703 0.02309700495115214 0.05115187354766352 5.4284915942163e-06 5.265320830321761 -0.11169808159986427 EEPVIVT(ph)PPTK ddPTM_A459_Selumetinib_30min_R2 1 EEPVIVTPPTK 11 0 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 EEPVIVT(1)PPTK 138.2 0.0029701000000000003 3695800.0 42193.0 33022.0 38025.0 45152.0 51173.0 44678.0 46919.0 47371.0 43748.0 45290.0 True False 39848.08197196152 35554.681217534635 35578.512898489644 39002.21970845552 44744.19024757558 50831.988953496824 49100.82646823471 47508.841767308804 52498.82242125102 43982.36002244814 0.9060014503910993 0.8083850252553044 0.8089268715987669 0.8867695978239729 1.0173212675431378 1.155735820623375 1.1163754387707743 1.080179457015512 1.1936335929780977 1.0 15.424637398506606 -6.349362138582623 2.3815515233506974 1.1142048830988351 0.8390883882042841 0.8302909946952446 0.05478114830697233 0.10767022729386307 1.1967032165800506 0.017758907492846473 0.021301424394714958 4.4734013185041815e-07 6.349362138582623 -0.27511649489455103 EEPVLT(ph)LVDEAIVK ddPTM_A459_Selumetinib_30min_R1 4 EEPVLTLVDEAIVK 14 0 Q02156 Q02156 PRKCE Protein kinase C epsilon type 1 EEPVLT(1)LVDEAIVK;EEPVLT(1)LVDEAIVK;EEPVLT(1)LVDEAIVK;EEPVLT(1)LVDEAIVK 226.24 3.7405999999999987e-51 6474400.0 4143.37 3193.29 2137.36 2405.71 2209.55 3014.61 1943.22 2691.46 2899.7299999999996 2067.33 True False 4239.902459405431 2819.4181222797533 1847.1182516780905 1985.597909269614 2009.6965926277378 2984.2857604468804 1796.6413509046024 2620.073737705805 4920.63002210026 2332.6919429994687 1.8176006789621755 1.208654289196212 0.7918397700225225 0.8512045129784488 0.8615353598913663 1.2793312762119657 0.7702008644117873 1.1231974910226719 2.1094212790794473 1.0 11.187780081203353 -8.034023701260894 24.737859569154754 1.5752438921141718 1.0581093791471226 0.18693938383202735 0.38728835957588453 822.0732319409959 597705.4964426327 0.2548320830686126 0.09644922856264225 9.246477106798686e-09 8.034023701260894 -0.5171345129670493 EEPVS(ph)SGPEEAVGK ddPTM_A459_Selumetinib_30min_R1 2 EEPVSSGPEEAVGK 14 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EEPVS(0.994)S(0.006)GPEEAVGK;EEPVS(0.5)S(0.5)GPEEAVGK 228.93 3.1873e-13 341422000.0 4601.6 6311.7 5581.4 6058.2 5514.2 5267.9 4939.4 4162.4 2030.95 4080.9 True False 4708.808326845065 5572.7232297702785 4823.4765364356435 5000.249096498406 5015.441583611083 5214.909708870507 4566.8170812662465 4051.9996306193107 3446.3738152809146 4604.723266332192 1.0226039773712134 1.210218922495451 1.0475062794115955 1.0858956786954241 1.0891950055461295 1.1325131625172227 0.991767977601803 0.8799659385061932 0.7484431997204603 1.0 12.168898740807853 -7.587484010219688 2.765826489946282 0.8579499172015326 1.0993185269340293 0.640404856694865 0.07424178529518527 0.15379505335932248 2.3744322448773656 0.03860513973439793 0.020273463855366672 2.585330024050704e-08 7.587484010219688 0.24136860973249674 EEPVS(ph)SGPEEAVGK ddPTM_A459_Selumetinib_30min_R2 1 EEPVSSGPEEAVGK 14 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EEPVS(0.941)S(0.059)GPEEAVGK 154.1 0.00035062 34731000.0 48553.0 44618.0 52263.0 53326.0 54501.0 42158.0 49179.0 54039.0 42236.0 47627.0 True False 45854.61863305872 48040.05713051783 48900.45547965192 46062.90680751904 47654.09713487809 47964.881827779194 51465.92094633978 54196.24454336197 50684.38017244125 46251.88476019296 0.9914108121389218 1.038661610863994 1.057264060333785 0.9959141567169914 1.0303168699384972 1.0370362651482807 1.1127313235596903 1.1717629416478696 1.0958338332638748 1.0 15.497224536070954 -7.212726078238929 4.569162940903008 1.1096509706530318 1.025163647249863 0.36233064184401753 0.04400051754457907 0.19314458836010892 8.987307369567676 0.01698187994270423 0.01267633237630048 6.127367401905012e-08 7.212726078238929 -0.08448732340316867 EEPVSS(ph)GPEEAVGK ddPTM_A459_Selumetinib_30min_R1 3 EEPVSSGPEEAVGK 14 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EEPVS(0.064)S(0.936)GPEEAVGK;EEPVS(0.04)S(0.96)GPEEAVGK;EEPVS(0.276)S(0.724)GPEEAVGK 218.11 1.0923e-08 329785400.0 8180.3 10520.8 9910.1 10026.400000000001 9645.8 8658.5 9219.8 8830.7 4333.15 7553.5 True False 8370.885073907048 9289.019845012775 8564.362852282742 8275.477458837882 8773.339093104309 8571.40335128899 8524.343063096429 8596.481149843828 7353.039069245675 8523.065302320625 0.9821448947044742 1.0898684353015105 1.0048453870171419 0.970950845182973 1.029364293467931 1.0056714394708677 1.0001499179849596 1.0086137844682728 0.8627223667104392 1.0 13.0571566706445 -8.129042174815961 9.896573556153763 0.9315243037036747 1.012796724824826 0.35557285763896596 0.04313134856071771 0.3687765551439056 27.440802922663497 0.027660288682051296 0.010432865680219141 7.4294698599245055e-09 8.129042174815961 0.0812724211211513 EEPVSS(ph)GPEEAVGK ddPTM_A459_Selumetinib_30min_R2 4 EEPVSSGPEEAVGK 14 0 O00567 O00567 NOP56 Nucleolar protein 56 1 EEPVS(0.018)S(0.982)GPEEAVGK;EEPVS(0.028)S(0.972)GPEEAVGK;EEPVS(0.321)S(0.679)GPEEAVGK;EEPVS(0.012)S(0.988)GPEEAVGK 235.38 9.445899999999997e-65 285936800.0 188942.0 156147.0 188366.0 182828.0 176472.0 138444.0 178785.0 184765.0 139963.0 172436.0 True False 178441.3600347536 168122.9728082605 176246.73663739394 157926.5110041085 154302.0096803031 157513.4043304964 187098.85675575645 185302.63556050765 167959.51089296822 167457.32463746684 1.0655930424128441 1.0039750316818612 1.0524874741606887 0.9430851194237584 0.9214407910454556 0.9406181824026014 1.1172927619667408 1.106566320474035 1.0029988909508054 1.0 17.35343395580864 -7.258871863292065 24.994577732479204 1.0655950192599095 0.986481243520881 0.2583990936779492 0.05631227816734987 309.5462592138002 3013427.5183347166 0.023691010785659928 0.01749505192612737 5.5097023380998984e-08 7.258871863292065 -0.07911377573902856 EEQSQITSQVT(ph)GQIGWR ddPTM_A459_Selumetinib_30min_R1 2 EEQSQITSQVTGQIGWR 17 0 A0A087WY71;E9PFW3;Q96CW1-2;Q96CW1 A0A087WY71 AP2M1 AP-2 complex subunit mu 1 EEQSQIT(0.01)S(0.081)QVT(0.909)GQIGWR;EEQSQIT(0.001)S(0.003)QVT(0.996)GQIGWR 177.66 2.0746e-07 3617200.0 1630.35 1255.5900000000001 1495.92 1321.8400000000001 1415.48 1303.57 1449.13 1365.76 1176.8 1275.54 True False 1668.333982891135 1108.5849390920453 1292.7822805003782 1091.0054580098797 1287.4500839232908 1290.45726934686 1339.8209573987433 1329.5356081862928 1996.9436499286448 1439.2679838117497 1.1591545158065202 0.7702422005914943 0.8982220788908126 0.758028018604615 0.8945172812874047 0.8966066666259189 0.9309044406381977 0.9237582042679486 1.3874717372924186 1.0 10.491119523662364 -8.132008985246205 7.286835585362504 1.1915271903067317 0.8927266906004382 0.42585344950512627 0.13449190992522536 0.21244561756567354 11.401426763587196 0.08564248191600772 0.03201214962300032 7.378889635694902e-09 8.132008985246205 -0.2988004997062935 EEQSQITSQVT(ph)GQIGWR ddPTM_A459_Selumetinib_30min_R2 1 EEQSQITSQVTGQIGWR 17 0 A0A087WY71;E9PFW3;Q96CW1-2;Q96CW1 A0A087WY71 AP2M1 AP-2 complex subunit mu 1 EEQS(0.011)QIT(0.008)S(0.004)QVT(0.978)GQIGWR 156.83 0.00010346 2758900.0 6155.8 5224.3 6075.2 7570.4 6753.3 7137.0 6675.7 6212.4 5002.4 5266.1 True False 5813.685279619857 5624.987011227852 5684.328246177632 6539.298460331579 5904.89007873199 8120.056966764556 6986.1332776486015 6230.477055481815 6003.019778734252 5114.054010029018 1.136805608274534 1.0999076271382466 1.11151118760777 1.2786917086733063 1.154639756864532 1.5877925713808567 1.3660656035208671 1.2183048992567176 1.1738279977023922 1.0 12.320251681766788 -5.761861755703203 24.56820349485893 1.2776987824933081 1.1144580611926185 0.14622057417423573 0.14534942846817392 14.743343850111192 857697.1030360532 0.041122740043200746 0.06549752129807204 1.7303670807212877e-06 5.761861755703203 -0.16324072130068967 EEQT(ph)DTSDGESVTHHIR ddPTM_A459_Selumetinib_30min_R2 1 EEQTDTSDGESVTHHIR 17 0 A2AB27;P36915 A2AB27 GNL1 Guanine nucleotide-binding protein-like 1 1 EEQT(0.671)DT(0.089)S(0.237)DGES(0.002)VTHHIR 60.768 0.045937 25640000.0 34931.0 24764.0 49836.0 51282.0 55705.0 33965.0 35534.0 51236.0 39521.0 36519.0 True False 32989.6748598722 26663.31917118974 46629.606017334125 44297.303133615686 48706.83989098151 38643.37044642817 37186.401409285216 51385.08827742358 47426.30430900298 35464.60158224296 0.930214168157751 0.7518290910263602 1.314821087421477 1.2490568385743612 1.3733931220975255 1.089632160587328 1.0485498144692074 1.4489120414411187 1.3372856931444908 1.0 15.11409211965448 -5.262913599352431 24.999882465626463 1.2426605861682174 0.8410216108419416 0.5384576644205903 0.14481855054279666 89.83799763830184 1523509.4866385227 0.03796825231059484 0.08653577510077934 5.458664476043311e-06 5.262913599352431 -0.4016389753262758 EEQTDTS(ph)DGESVTHHIR ddPTM_A459_Selumetinib_30min_R1 3 EEQTDTSDGESVTHHIR 17 0 A2AB27;P36915 A2AB27 GNL1 Guanine nucleotide-binding protein-like 1 1 EEQT(0.015)DT(0.355)S(0.629)DGES(0.001)VTHHIR;EEQTDT(0.002)S(0.998)DGESVTHHIR;EEQT(0.075)DT(0.187)S(0.739)DGESVTHHIR 295.82 1.5786999999999994e-76 25827700.0 9120.9 7909.58 8387.06 9607.54 12028.599999999999 8191.0 10320.2 9196.03 3068.45 6172.3099999999995 True False 9333.399223818047 6983.522696536015 7248.143318822867 7929.763494861891 10940.61525382181 8108.605976832947 9541.73900515931 8952.121411484735 5206.935539279019 6964.586111890726 1.3401225965004606 1.0027189820530698 1.0407141504716295 1.1385835952725611 1.5708923801147006 1.1642624337703316 1.3700367619647316 1.28537737457229 0.7476302906771664 1.0 12.765821904241681 -8.254095915736015 24.97671570221889 0.8738151372979923 1.2341777786083148 0.430152176648985 0.16809316221797316 499.2642952611125 1698120.6872160782 0.12398426242732431 0.04473862862317772 5.570627057381389e-09 8.254095915736015 0.3603626413103225 EEQTDTS(ph)DGESVTHHIR ddPTM_A459_Selumetinib_30min_R2 1 EEQTDTSDGESVTHHIR 17 0 A2AB27;P36915 A2AB27 GNL1 Guanine nucleotide-binding protein-like 1 1 EEQT(0.021)DT(0.06)S(0.92)DGESVTHHIR 121.0 0.00095559 17361000.0 17208.0 14158.0 16167.0 25733.0 28071.0 18917.0 20480.0 18855.0 21579.0 18931.0 True False 16251.648249081934 15243.873074854797 15126.832821298678 22228.121008098988 24544.47002207596 21522.64503857152 21432.360580350112 18909.86492838671 25895.402967636834 18384.412841354962 0.8839906060271088 0.8291737792443579 0.8228075028467324 1.2090742957043352 1.335069563215215 1.1707007030519483 1.1657897788358473 1.0285813907447598 1.4085520811078729 1.0 14.166195480246634 -5.762007062817782 24.997314495318832 1.1938935667120272 0.8437088805501519 0.6467517347686556 0.11608649293146107 8.691717417390949 382762.91062491486 0.03119148692991277 0.04961589169271081 1.7297882278919864e-06 5.762007062817782 -0.35018468616187526 EERAVAEEMMPAAEKEEAK ddPTM_A459_Selumetinib_30min_R1 1 EERAVAEEMMPAAEKEEAK 19 2 Q9UMN6;A0A669KBI7;Q9UMN6-2 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 0 73.168 0.017929 38361000.0 911.41 709.7 1362.1 1343.1 1221.4 907.02 1096.5 957.05 686.54 677.56 False True 932.6440797048544 626.6079940694214 1177.1343014797346 1108.5527981095063 1110.924585655684 897.8962023082678 1013.7901222027851 931.6659250634755 1165.0082371023216 764.531425993296 1.2198897886939608 0.8195974328397534 1.539680726597178 1.4499767575534912 1.4530790336216022 1.174439887989825 1.3260280581477037 1.2186103715135512 1.52381994708552 1.0 9.57843199442537 -5.262094524220741 24.999999413812635 1.3456799434484858 1.0197436169455465 0.3203120765449281 0.18364374948249879 59.90282695901597 2285972.652033526 0.04546527242633485 0.10481540937543096 5.468969177915058e-06 5.262094524220741 -0.32593632650293936 EERS(ph)PQTLAPVGEDAMK ddPTM_A459_Selumetinib_30min_R1 4 EERSPQTLAPVGEDAMK 17 1 Q92797 Q92797 SYMPK Symplekin 1 EERS(1)PQTLAPVGEDAMK;EERS(1)PQTLAPVGEDAMK;EERS(1)PQTLAPVGEDAMK;EERS(0.987)PQT(0.013)LAPVGEDAMK 201.48 2.4090000000000003e-08 142574000.0 21908.0 28193.7 19108.8 19072.7 19225.0 20700.0 23037.2 23131.600000000002 11120.1 19453.2 True False 22418.413774452736 24892.76849710445 16513.929917125 15742.010983920169 17486.102144449436 20491.776794096208 21299.48545664388 22518.074825973865 18869.99752003019 21950.207710214276 1.021330370555928 1.1340561704808327 0.752335929351613 0.7171691125544477 0.7966258167257562 0.9335573068204086 0.9703546197757578 1.0258706944032852 0.85967284543049 1.0 14.421946971295425 -10.324543738759617 12.863682492348778 0.9999999963916066 0.9106731842082786 0.04189659810059343 0.12554813548116578 0.0 0.0 0.13459722288505924 0.03264462158058247 4.7364860357204033e-11 10.324543738759617 -0.08932681218332805 EERS(ph)PQTLAPVGEDAMK ddPTM_A459_Selumetinib_30min_R2 5 EERSPQTLAPVGEDAMK 17 1 Q92797 Q92797 SYMPK Symplekin 1 EERS(0.999)PQT(0.001)LAPVGEDAMK;EERS(0.998)PQT(0.002)LAPVGEDAMK;EERS(0.986)PQT(0.014)LAPVGEDAMK;EERS(0.997)PQT(0.003)LAPVGEDAMK;EERS(0.982)PQT(0.018)LAPVGEDAMK 112.12 0.0010753 170949300.0 375417.0 298504.0 396356.0 383105.0 414672.0 316742.0 303124.0 372051.0 272941.0 351730.0 True False 354552.8260533233 321398.2969583595 370854.88647978316 330925.43810701213 362577.1961452849 360370.3354024013 317219.86662881094 373133.60681364103 327536.8266087289 341574.6409957089 1.0379951656240707 0.9409313759987151 1.0857213679526114 0.9688232040363016 1.0614874543623978 1.055026609562999 0.9286985289777296 1.092392590169856 0.9589026446867983 1.0 18.38184134556684 -5.239093930219982 24.805818803968105 1.0199852124558144 0.9894633040328233 0.040822235316536726 0.05683871747099163 2527.224885669888 2805476.2447183067 0.013321240882973994 0.03518612800091211 5.766417324899934e-06 5.239093930219982 -0.030521908422991073 EES(ph)DDEAAVEEEEEEKKPK ddPTM_A459_Selumetinib_30min_R2 1 EESDDEAAVEEEEEEKKPK 19 2 P14625 P14625 HSP90B1 Endoplasmin 1 EES(1)DDEAAVEEEEEEKKPK 86.575 0.0013879 3976500.0 21731.0 12305.0 17132.0 16141.0 18161.0 12902.0 28297.0 28293.0 15511.0 11699.0 True False 20523.2780160855 13248.753933188897 16029.745771911235 13942.567955221924 15879.45281860003 14679.13338730507 29612.86656944176 28375.327945841695 18613.6334135509 11361.219472347564 1.806432669137126 1.1661383679309658 1.410917710983979 1.2272069903373655 1.3976891175502364 1.2920385371511467 2.606486622454347 2.497560056374698 1.6383481948267276 1.0 13.471830076388969 -7.23237437326145 24.712806505096367 2.060395476116956 1.368328202167561 0.24552749761535564 0.4531135196461238 666.5729513801014 566760.8228550382 0.16625447725492756 0.12875797221702384 5.8563311571998507e-08 7.23237437326145 -0.6920672739493949 EES(ph)DGEYDEFGR ddPTM_A459_Selumetinib_30min_R1 2 EESDGEYDEFGR 12 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 EES(1)DGEYDEFGR;EES(1)DGEYDEFGR 148.89 0.00059074 3200400.0 2326.8 2392.2 1948.08 2153.85 1891.65 1936.6799999999998 2362.8999999999996 2427.3 1427.8600000000001 2253.8999999999996 True False 2381.0099128353404 2112.120111896392 1683.5414360374734 1777.7205302718787 1720.5505914979324 1917.198757564747 2184.6645506182967 2362.9201190184153 2422.974133231744 2543.2100198451635 0.9362222916140845 0.8304937836101254 0.6619749933747002 0.6990065768851094 0.6765271362066604 0.7538499544294303 0.859018537034273 0.9291093148344373 0.9527227851120452 1.0 11.31243489025205 -7.585958394478354 1.9562730342313412 0.9672700607780962 0.7516079314779088 0.5827448851328539 0.07660830775576492 0.27105035288271756 2.0503183738296604 0.053592977465770825 0.025756487186409625 2.5944278970651076e-08 7.585958394478354 -0.21566212930018736 EES(ph)DGEYDEFGR ddPTM_A459_Selumetinib_30min_R2 4 EESDGEYDEFGR 12 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 EES(1)DGEYDEFGR;EES(1)DGEYDEFGR;EES(1)DGEYDEFGR;EES(1)DGEYDEFGR 246.63 3.4058999999999997e-18 75326000.0 109343.0 90617.0 97805.0 124664.0 120162.0 102354.0 130322.0 133480.0 101331.0 110695.0 True False 103266.15379470968 97567.03252042066 91512.33278203245 107684.54814260484 105066.1752980902 116452.3344228973 136382.23122814408 133868.4047011965 121600.03142470021 107498.94772985 0.9606247872697551 0.9076091867020994 0.8512858471136603 1.0017265323677518 0.9773693372527378 1.0832881333457105 1.268684336993504 1.2452996752825358 1.1311741555860333 1.0 16.713963012276132 -6.8007308180874615 2.146514769536663 1.1818123698547311 0.9266652158358736 0.6397328327796897 0.07848609429415784 0.17956379387721622 1.6997077529704852 0.031098272445422254 0.02789945094629726 1.5822284231488877e-07 6.8007308180874615 -0.25514715401885757 EES(ph)DGEYDEFGRK ddPTM_A459_Selumetinib_30min_R2 2 EESDGEYDEFGRK 13 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 EES(1)DGEYDEFGRK;EES(1)DGEYDEFGRK 82.925 0.01646 69223000.0 88990.0 55510.0 64040.0 77688.0 74137.0 58125.0 82841.0 90965.0 63751.0 51592.0 True False 84044.2920551953 59767.43850721784 59919.73612147998 67106.76038072506 64823.247266810875 66131.19114378448 86693.27064632726 91229.69308993359 76502.98135176853 50102.40490788575 1.6774502583201818 1.1929055824186772 1.1959453090454157 1.339392001324131 1.2938150850441148 1.3199204961392166 1.7303215445588795 1.8208645524633231 1.5269323197643057 1.0 15.612592233776526 -7.239293525430456 23.029941966515736 1.5879349589500935 1.3218337522452952 0.09362042209904964 0.2416504644243093 440.9898487969763 458594.6673524063 0.08863247165161242 0.06857415161224237 5.7637677751390847e-08 7.239293525430456 -0.2661012067047983 EES(ph)EEEEDEDDEEEEEEEKEK ddPTM_A459_Selumetinib_30min_R2 5 EESEEEEDEDDEEEEEEEKEK 21 1 D6R9L5;H0Y8X0;A0A494C198;B4DFG0;H0Y993;P35659;A0A494C028 D6R9L5 DEK Protein DEK 1 EES(1)EEEEDEDDEEEEEEEKEK;EES(1)EEEEDEDDEEEEEEEKEK;EES(1)EEEEDEDDEEEEEEEKEK;EES(1)EEEEDEDDEEEEEEEKEK;EES(1)EEEEDEDDEEEEEEEKEK 124.21 3.9271e-05 999945900.0 219330.0 148753.0 171947.0 189041.0 160676.0 147728.0 200989.0 183021.0 139122.6 128210.0 True False 207140.51664755592 160161.8767837178 160884.11722173798 163293.28968608574 140490.4444183348 168076.19105873536 210335.38675214775 183553.56080924248 166951.00741023017 124508.24417041466 1.6636690849486426 1.286355597180408 1.2921563410816042 1.3115058426379054 1.1283625863846034 1.3499201774035876 1.6893289930605826 1.4742281688432806 1.3408831561524877 1.0 16.925881746288375 -7.017696284350154 24.90756817567024 1.430485579044744 1.3207224349870392 0.0 0.2046842734574029 2320.467432315399 3266058.824145419 0.07560997295385054 0.05986111409878451 9.600718049004919e-08 7.017696284350154 -0.10976314405770471 EES(ph)EES(ph)EAEPVQR ddPTM_A459_Selumetinib_30min_R2 1 EESEESEAEPVQR 13 0 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 2 EES(1)EES(1)EAEPVQR 135.14 0.021167 3190400.0 21072.0 27185.0 21320.0 27176.0 21816.0 18600.0 20687.0 20812.0 17584.0 18329.0 True False 19900.902597899483 29270.002086447785 19948.294411460865 23474.581918785138 19075.279042485465 21161.981166011024 21648.98649051284 20872.559474387926 21101.291338010393 17799.794145538806 1.1180411658236666 1.6444011569529178 1.120703658051042 1.3188119888829508 1.071657283590908 1.1888890957379352 1.2162492618454672 1.172629262098475 1.1854795154077131 1.0 14.119572936082267 -1.5228792860827436 0.07670587393456191 0.8217604639494762 2.2037156870288737 0.22514404445590896 0.1478985271815039 290.16243891754146 1.6359936929805536 4.670436647651912 42.71685570439588 0.02999996264271651 1.5228792860827436 1.3819552230793974 EES(ph)EESEAEPVQR ddPTM_A459_Selumetinib_30min_R1 2 EESEESEAEPVQR 13 0 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 EES(0.9)EES(0.1)EAEPVQR;EES(0.995)EES(0.005)EAEPVQR 231.69 3.2646e-13 15903700.0 1970.76 1491.04 2093.35 2114.2 2169.3 1407.0 1665.53 1800.17 904.74 1677.72 True False 2016.674873568581 1316.4683436343098 1809.0845679484648 1744.994658449197 1973.0871980210225 1392.846857453787 1539.8977311741048 1752.423643823747 1535.2777004048633 1893.071704376694 1.0652923863930364 0.6954138824169713 0.9556344663363491 0.921779483796018 1.0422675451010843 0.7357602219892619 0.8134386709251069 0.9257037859539207 0.8109981765906555 1.0 10.886513342079557 -6.763923810088831 24.99977032917999 0.8498028418369457 0.9229994934640054 0.0989199324511757 0.11466818515832759 175.55643202197322 1766531.8228586565 0.03858473573748391 0.03563010416846986 1.7221706753520115e-07 6.763923810088831 0.0731966516270598 EES(ph)EESEAEPVQR ddPTM_A459_Selumetinib_30min_R2 2 EESEESEAEPVQR 13 0 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 EES(1)EESEAEPVQR;EES(1)EESEAEPVQR 190.37 0.00016321 50182000.0 12400.8 10042.9 13935.0 13427.2 13494.8 9714.3 12225.099999999999 13522.7 12007.3 11838.9 True False 11711.613180335604 10813.158136986807 13038.437271280822 11598.39219678804 11799.462578957313 11052.356647364564 12793.591373576091 13562.048818196507 14409.095511993404 11497.080195843706 1.0186597797734291 0.9405134132138921 1.134065088629575 1.0088119765382657 1.0263007979384993 0.9613185660268845 1.1127687339435177 1.1796080906784754 1.2532830306952558 1.0 13.48897989969116 -7.461873703651499 4.866982959908864 1.1602790485644534 1.0176265709875407 0.3794127965428655 0.07592507524268524 0.20064062134006147 9.648209492872159 0.03252128114904464 0.020921534586568858 3.4524412452295144e-08 7.461873703651499 -0.14265247757691268 EES(ph)EPEVKEDVIEK ddPTM_A459_Selumetinib_30min_R1 2 EESEPEVKEDVIEK 14 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 EES(1)EPEVKEDVIEK;EES(1)EPEVKEDVIEK 81.65100000000002 0.017308 8716000.0 3462.3 3554.0 2419.3 2217.52 2799.8 2840.6 3891.3 4434.200000000001 2276.2 3971.2 True False 3542.9648535369597 3137.8960277902247 2090.772348263655 1830.271760005801 2546.5585843448384 2812.026143058441 3597.7761080963974 4316.590611688483 3862.545152929625 4480.942202763709 0.7906740799628629 0.7002759432725701 0.46659212586454035 0.4084568997290224 0.5683087326531903 0.6275524244262889 0.8029061624310615 0.9633220908375342 0.8619939687120545 1.0 12.129586402733864 -7.383464998614632 2.18593734040254 0.9365270783455117 0.5773450861450408 0.688160377254853 0.10637199834560777 0.205018388179536 1.9134137055758744 0.062394523180201784 0.03672922026694205 4.135566430514113e-08 7.383464998614632 -0.359181992200471 EES(ph)EPEVKEDVIEK ddPTM_A459_Selumetinib_30min_R2 2 EESEPEVKEDVIEK 14 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 EES(1)EPEVKEDVIEK;EES(1)EPEVKEDVIEK 84.859 0.013933 7507600.0 54293.0 36871.0 44757.0 46871.0 45444.0 35821.0 44493.0 47978.0 30709.9 40027.0 True False 51275.612412099326 39698.887141049 41877.38334773707 40487.088943015115 39734.91844548539 40755.01759933769 46562.01266120694 48117.608036814505 36852.738106299206 38871.3165073644 1.319111803233751 1.0212900078526492 1.0773338057588855 1.041567216673626 1.0222169459569854 1.0484599252411844 1.1978501590597144 1.237869266087202 0.9480702332095503 1.0 15.246418349755043 -6.682910104220352 0.010291722002654163 1.7340565955541106e-06 2.191000563440008 0.10271800888603211 0.10706924053841745 9105.80648898671 34.736054638981685 3585.768355097111 3806.121746474374 2.0753430538230062e-07 6.682910104220352 2.190998829383412 EES(ph)SEDENEVSNILR ddPTM_A459_Selumetinib_30min_R2 1 EESSEDENEVSNILR 15 0 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 EES(0.5)S(0.5)EDENEVSNILR 262.83 1.3091e-36 5224400.0 17359.0 15882.0 18737.0 20458.0 22025.0 14854.0 15159.0 15392.0 14986.0 17048.0 True False 16394.25627358281 17100.0983313211 17531.481819303117 17671.58510798156 19258.022594001748 16900.003668813322 15863.923536988637 15436.788171717228 17983.618743825285 16555.77994397651 0.9902436689216525 1.0328778462377803 1.0589342138291464 1.0673967138836615 1.1632204981685803 1.0207917552662356 0.958210582084984 0.9324108090318991 1.0862441277113173 1.0 14.015047357351836 -6.994800129776218 24.99953346206435 0.9887149683672052 1.0640619922000398 0.2564122957113595 0.05480089816686979 188.97356196935598 908525.6781219869 0.01994834893677769 0.01753384428118824 1.012045108676383e-07 6.994800129776218 0.07534702383283465 EES(ph)WESGR ddPTM_A459_Selumetinib_30min_R1 1 EESWESGR 8 0 B8ZZ08;Q9NQ29-3;Q9NQ29 B8ZZ08 LUC7L Putative RNA-binding protein Luc7-like 1 1 EES(0.999)WES(0.001)GR 94.409 0.022719 6571200.0 1807.0 1950.9 2131.7 1745.5 1613.6 1748.5 1771.3 1546.8 1132.9 1384.6 True False 1849.099584190071 1722.4877210511963 1842.2268485899347 1440.6811920930254 1467.650164904218 1730.911677510977 1637.6894149181876 1505.773839285495 1922.4485562577852 1562.3268971461086 1.1835548549844517 1.1025142844289837 1.1791558168492888 0.9221381227736061 0.9394001777637984 1.1079062139126075 1.048237355389415 0.9638020327474879 1.230503398340967 1.0 10.609480635420221 -5.735022936442898 24.99927681945495 1.0289711088100655 1.1498189708750661 0.30030075486295105 0.08716439076305647 292.14981759315316 276474.5436463823 0.02357648455677551 0.04082059037814584 1.8406747871391077e-06 5.735022936442898 0.12084786206500064 EES(ph)WESGR ddPTM_A459_Selumetinib_30min_R2 2 EESWESGR 8 0 B8ZZ08;Q9NQ29-3;Q9NQ29 B8ZZ08 LUC7L Putative RNA-binding protein Luc7-like 1 1 EES(0.99)WES(0.01)GR;EES(0.999)WES(0.001)GR 122.94 0.0061569 53406000.0 87048.0 68480.0 100096.0 110082.0 125865.0 81167.0 83029.0 93437.0 73791.0 90990.0 True False 82210.22064075342 73732.19580209457 93655.93233628462 95088.64169795795 110052.71345262337 92347.01748933425 86890.0130188423 93708.88620067196 88551.26189280745 88362.88227958824 0.9303705189316116 0.8344249746041461 1.0599012834365076 1.0761152108765397 1.245463147121056 1.0450883346826536 0.9833315842268969 1.0605005606785038 1.0021318862440811 1.0 16.43115285780182 -5.27252432072303 23.543834836430655 1.0652891208751034 0.8823977551628577 0.48541647946887256 0.07253360337107168 245.25829297979533 520917.88684356725 0.02009033144968802 0.04254860301225457 5.339193729668002e-06 5.27252432072303 -0.18289136571224573 EES(ph)WGPPR ddPTM_A459_Selumetinib_30min_R1 2 EESWGPPR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 EES(1)WGPPR;EES(1)WGPPR 131.5 0.0035513000000000007 17729000.0 6036.4 5920.200000000001 5229.200000000001 5937.200000000001 5726.0 5351.4 5648.4 5313.799999999999 3179.2 4742.299999999999 True False 6177.036375210262 5227.060231773687 4519.10336193953 4900.3794750471025 5208.084311007408 5297.569774682438 5222.336640447067 5172.8607623450125 5394.87020041906 5351.02039891376 1.1543660675381056 0.976834293667571 0.8445311408001536 0.9157841140059686 0.9732880689568354 0.9900111342797026 0.9759515477659523 0.966705483573766 1.0081946616227069 1.0 12.3855983133875 -8.259365747665903 21.92861217545788 1.0040973350914018 0.9689605260476759 0.020620817868032493 0.07300479855659167 141.014686034163 1491518.6718978533 0.05817628908214808 0.019371828179295853 5.503440206470231e-09 8.259365747665903 -0.03513680904372585 EES(ph)WGPPR ddPTM_A459_Selumetinib_30min_R2 2 EESWGPPR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 EES(1)WGPPR;EES(1)WGPPR 111.06 0.011759 12956100.0 136329.0 118429.0 130453.0 153867.0 146458.0 134575.0 123309.0 140080.0 97830.0 134904.0 True False 128752.379948227 127512.12349074599 122059.79600648726 132910.04916462023 128058.63668886763 153111.48469978123 129043.11283214805 140487.60960850772 117398.733598587 131008.97099731382 0.9827752936924213 0.9733083354525429 0.9316903649979049 1.0145110533487465 0.9774799062538497 1.168709925238025 0.9849944767125445 1.072351065267036 0.8961121723564573 1.0 16.999306079865207 -6.065785309283119 2.459919231681425 1.026641481205413 0.9649278637881434 0.09743935592134967 0.06791781796600772 0.6021347994644682 7.20301817704141 0.02098549517487394 0.030484207366890833 8.594382743584014e-07 6.065785309283119 -0.06171361741726955 EES(ph)YSPSKDR ddPTM_A459_Selumetinib_30min_R1 1 EESYSPSKDR 10 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 EES(0.809)YS(0.19)PS(0.001)KDR 140.78 0.0065539000000000005 64072000.0 5259.4 6737.4 5671.8 5499.7 4581.6 5275.3 5756.5 5596.3 3337.5 4837.3 True False 5381.933786989079 5948.582075867713 4901.600712967303 4539.2806371549805 4167.195088947179 5222.23527158917 5322.282570415262 5447.86794465569 5663.493738644503 5458.214574292124 0.9860245898608817 1.0898402755885033 0.8980227226781372 0.8316420278775281 0.7634721999707428 0.9567662099957736 0.9750958849223162 0.9981043930216364 1.037609214800611 1.0 12.414213395870371 -7.337724350906159 2.5861622897172096 1.0096395929222541 0.9153865974942363 0.20296502958234852 0.08249638647978136 0.5575825652775249 7.297227686774848 0.04603787014331279 0.029021113825320487 4.594895608523987e-08 7.337724350906159 -0.0942529954280178 EES(ph)YSPSKDR ddPTM_A459_Selumetinib_30min_R2 1 EESYSPSKDR 10 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 EES(0.656)YS(0.342)PS(0.003)KDR 177.04 0.00036376 40976000.0 59251.0 50879.0 53011.0 56996.0 54061.0 38893.0 50455.0 51485.0 38805.0 46179.0 True False 55958.06662054587 54781.255698229834 49600.32997401273 49233.046476415926 47269.37386852796 44250.1577144982 52801.257474685786 51634.81282619941 46567.08430229148 44845.69228254878 1.2477913434357073 1.2215500064773752 1.1060221717953984 1.0978322324968197 1.0540449140735493 0.9867203618064712 1.1773986482807142 1.1513884656050353 1.0383847797219212 1.0 15.452681791202862 -5.262484219119843 2.2286190432429676 1.078490917201698 1.2511325995168308 0.5604493230730023 0.05678944069884144 0.2686796122358804 2.4741682619412257 0.016501536965069643 0.05981470319921212 5.464064041919612e-06 5.262484219119843 0.17264168231513266 EESDWPAS(ph)GSSSPLRGESAADSDGWDSAPSDLR ddPTM_A459_Selumetinib_30min_R1 1 EESDWPASGSSSPLRGESAADSDGWDSAPSDLR 33 1 I3L0Y2;I3L4Q4;Q9BUL5-4;Q9BUL5;A0A087WVQ2;Q9BUL5-2 I3L0Y2 PHF23 PHD finger protein 23 1 EES(0.002)DWPAS(0.478)GS(0.155)S(0.155)S(0.207)PLRGES(0.002)AADS(0.001)DGWDSAPSDLR 64.542 0.00011357 6334900.0 463.77 525.7 509.99 535.67 631.04 381.89 760.24 659.65 333.88 481.71 True False 474.57493866066926 464.1507996087006 440.73615917454697 442.12529027125265 573.9625434191607 378.0485333283772 702.8944847272643 642.1539391548208 566.5699743696263 543.542170752746 0.8731152138636001 0.8539370532481462 0.8108591805566365 0.8134148812390359 1.0559669043236994 0.6955275113333371 1.2931737821811193 1.1814243194148275 1.0423661766390442 1.0 9.086248160953117 -7.262905661658887 24.99999985746663 1.1443597618156467 0.8564836484473973 0.5978811409817544 0.1116610633157355 88.73239482434396 1512858.7643680885 0.04360221463806543 0.03117643555782955 5.4587642461383694e-08 7.262905661658887 -0.28787611336824936 EESDWPASGSS(ph)SPLR ddPTM_A459_Selumetinib_30min_R2 2 EESDWPASGSSSPLR 15 0 I3L0Y2;I3L4Q4;Q9BUL5-4;Q9BUL5;A0A087WVQ2;Q9BUL5-2 I3L0Y2 PHF23 PHD finger protein 23 1 EESDWPASGS(0.024)S(0.834)S(0.142)PLR;EESDWPASGS(0.071)S(0.686)S(0.242)PLR 204.67 5.667e-06 12459600.0 48491.0 23741.0 33694.0 52291.0 54799.0 50253.0 81969.0 86998.0 83967.0 32132.0 True False 45796.064344853075 25561.858360653183 31526.164723253383 45168.87559299359 47914.659710724256 57174.8945986856 85780.72091849212 87251.14977670569 100762.74623400366 31204.26567103784 1.467621921555378 0.8191783338256332 1.0103158669269476 1.4475224659722392 1.535516336639709 1.832278163550964 2.7490062359682215 2.7961289234147118 3.2291337119183146 1.0 14.929455640745893 -6.86661102484438 1.6316973129392929 2.59492274054746 1.1551866269552662 0.4718143337757488 0.5843717413490592 0.282411796743686 1.5494816879392173 0.2540944155201054 0.2126575577690148 1.3595305628180653e-07 6.86661102484438 -1.439736113592194 EESEES(ph)DEDMGFGLFD ddPTM_A459_Selumetinib_30min_R1 2 EESEESDEDMGFGLFD 16 0 F8VWS0;P05388-2;Q8NHW5;P05388;F8W1K8 F8VWS0 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 EES(0.1)EES(0.9)DEDMGFGLFD;EES(0.003)EES(0.997)DEDMGFGLFD 127.79 0.001008 2590800.0 1572.4499999999998 1555.48 1469.45 1472.88 1359.05 1451.92 1616.4099999999999 1604.5700000000002 840.4000000000001 1431.62 True False 1609.0850255449247 1373.3636784769665 1269.9067611110768 1215.6691573818255 1236.1241674597654 1437.3150030378827 1494.4828923208422 1562.0115912220897 1426.0974196125376 1615.3823721596941 0.996101637158297 0.8501786958593838 0.7861338485533107 0.7525581424765272 0.7652207853470151 0.8897676660395004 0.925157360930456 0.9669608992536857 0.8828234380853798 1.0 10.657659985881073 -7.0223383059765805 3.831698034824036 0.9391856266759019 0.8241999306187258 0.36815386072282763 0.06960510177647074 0.266099989477447 8.534185738458145 0.028711127323647615 0.023133021633018527 9.498645814935664e-08 7.0223383059765805 -0.11498569605717612 EESGKPGAHVTVK ddPTM_A459_Selumetinib_30min_R1 2 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 100.38 0.012904 20855500.0 13562.0 14595.4 14090.1 14779.6 17261.3 14614.9 17336.7 14331.9 5312.599999999999 9945.6 False True 13877.968212941756 12886.563782782618 12176.74181137921 12198.62030745236 15700.018462730037 14467.887375267474 16028.978761142758 13951.771455427852 9015.094183048024 11222.214638347783 1.236651468554069 1.148308439828582 1.0850569342854737 1.0870065045599886 1.399012491623624 1.2892185581470523 1.4283258053512566 1.2432279995565951 0.8033257671121582 1.0 13.454069791011216 -8.251212154157411 24.451793503678473 0.9016628872274308 1.2395784612629905 0.5690902111544491 0.11762504431584066 355.7798174756422 850623.9209371366 0.08951975488170258 0.03296105297027453 5.607739693448759e-09 8.251212154157411 0.3379155740355597 EESGKPGAHVTVK ddPTM_A459_Selumetinib_30min_R2 2 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 87.21600000000002 0.020253 41597000.0 316030.0 262970.0 389980.0 450910.0 477210.0 319980.0 300050.0 341320.0 291470.0 384700.0 False True 298466.3177683262 283138.9534181782 364889.11137812 389495.28013686393 417258.61348847125 364054.34051076387 314002.91953779536 342313.1846914325 349772.14435224613 373592.71142936184 0.7989082994322806 0.7578813631960096 0.9767029714847971 1.0425665924976402 1.1168810330695267 0.974468530496475 0.8404953039271656 0.9162737232794126 0.9362392082383555 1.0 18.51110678364047 -5.26486624970694 24.38781051320991 0.9750559813589005 0.7783948175183536 0.5580329512483577 0.07014810701722725 160.84507278012964 1144690.8195982785 0.02111838930192386 0.04703663341253647 5.434176628397198e-06 5.26486624970694 -0.19666116384054688 EESHS(ph)NDQSPQIR ddPTM_A459_Selumetinib_30min_R1 1 EESHSNDQSPQIR 13 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 EES(0.005)HS(0.993)NDQS(0.002)PQIR 115.09 0.0040713 1524700.0 704.38 465.36 452.27 722.66 536.68 497.29 567.75 471.73 378.15 459.83 True False 720.7906835151095 410.8754348600052 390.85421814128176 596.4609970082761 488.1373887585497 492.28771410319337 524.9241604018529 459.2181880050085 641.692931016755 518.8536596234977 1.3891984187567374 0.7918907908602859 0.7533033850525449 1.1495746169374492 0.9407997413235226 0.9487987700817573 1.011699832247035 0.8850630220826365 1.2367512864463452 1.0 9.019183879984022 -8.254160750011428 24.97387532930248 1.1183756466094763 0.9735684308965405 0.07986715741601824 0.18006944713663442 1216.0226921642447 4172360.2424092228 0.12247005435926189 0.04421349153909963 5.5697955003928865e-09 8.254160750011428 -0.14480721571293576 EESHSNDQS(ph)PQIR ddPTM_A459_Selumetinib_30min_R1 2 EESHSNDQSPQIR 13 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 EESHS(0.001)NDQS(0.999)PQIR;EESHSNDQS(1)PQIR 176.42 6.6923e-05 6817900.0 1832.66 2128.06 1562.1499999999999 1580.38 1657.67 1578.17 2438.2400000000002 1412.78 932.0699999999999 1944.57 True False 1875.357412264402 1878.905745891746 1350.018610275728 1304.3963004067468 1507.734041185408 1562.2950426637121 2254.3215937617133 1375.3084850438079 1581.6547143006387 2194.1745012158085 0.854698389405789 0.8563155504954735 0.6152740402040369 0.594481569120401 0.6871532051575484 0.7120195051934259 1.027412173695655 0.6267999579257434 0.7208427194027786 1.0 11.099462551527886 EESHSNDQS(ph)PQIR ddPTM_A459_Selumetinib_30min_R2 2 EESHSNDQSPQIR 13 0 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 EESHS(0.004)NDQS(0.996)PQIR;EESHSNDQS(1)PQIR 148.7 0.00035668 30655000.0 35233.0 26836.9 38803.0 42495.0 47005.0 37557.0 34331.0 40222.0 35659.0 32333.0 True False 33274.890908874 28895.203935765727 36306.457225512 36707.10769203618 41099.81166996832 42730.1358414987 35927.45952558593 40339.03936088945 42791.79639570702 31399.462278777133 1.0597280492718648 0.9202451837939902 1.15627640063287 1.1690361881402815 1.308933615011224 1.3608556561294987 1.1442062034886906 1.2847047826087956 1.3628194016758672 1.0 14.938452232475774 -5.576106947962455 2.031853902149853 1.2545962774882289 0.9896125171310565 0.4198758082261125 0.11035135569229981 0.2804497970222954 2.2993101928625665 0.031121503464545043 0.07493917100174255 2.6539519278310813e-06 5.576106947962455 -0.2649837603571724 EESLVEELS(ph)PASEK ddPTM_A459_Selumetinib_30min_R1 3 EESLVEELSPASEK 14 0 A0A087WTL4;A0A087WX97;Q9BXK5-4;Q9BXK5 A0A087WTL4 BCL2L13 Bcl-2-like protein 13 1 EESLVEELS(0.617)PAS(0.383)EK;EESLVEELS(1)PASEK;EESLVEELS(0.999)PAS(0.001)EK 227.92 1.4753e-51 1965500.0 2470.56 3293.59 2450.2400000000002 2698.54 2776.96 3406.5 2708.25 3330.6000000000004 1610.35 2537.81 True False 2528.1192411270745 2907.97495165155 2117.510866204908 2227.290646869502 2525.7844583121073 3372.2337028545303 2503.964522075416 3242.261668686498 2732.646334689491 2863.5626338627517 0.8828580214139801 1.0155094626754817 0.7394672779859993 0.7778040614620808 0.8820426794384433 1.1776357405200584 0.874422822977592 1.1322475123629152 0.9542820200176089 1.0 11.48359544411425 -6.552288594559798 24.16065152534786 1.0267842202331907 0.8538587283801871 0.3957914120854795 0.10435913050827993 147.54653332213027 121210.49758059777 0.03394103784589875 0.033941607652867134 2.8035700086101394e-07 6.552288594559798 -0.17292549185300365 EESLVEELS(ph)PASEK ddPTM_A459_Selumetinib_30min_R2 2 EESLVEELSPASEK 14 0 A0A087WTL4;A0A087WX97;Q9BXK5-4;Q9BXK5 A0A087WTL4 BCL2L13 Bcl-2-like protein 13 1 EESLVEELS(0.96)PAS(0.04)EK;EESLVEELS(0.997)PAS(0.003)EK 190.41 0.00010176 3335500.0 32042.0 15694.1 23531.0 29649.0 23659.0 21529.0 35845.0 27000.0 24858.0 21151.0 True False 30261.233914288896 16897.787005514812 22017.041078615654 25610.7550526222 20686.74490585642 24494.424329196307 37511.86352552003 27078.56552990937 29830.294590551777 20540.315673102257 1.4732604111784064 0.8226644261189534 1.0718939975906594 1.2468530406355796 1.007128869637866 1.1925047657019212 1.826255454030932 1.3183130172322042 1.4522802407372364 1.0 14.326170733382753 -7.019139099747651 24.802672799242682 1.4376871191519325 1.1103223335605577 0.2136107616468612 0.2454090223332456 874.7659158493121 1133621.3919711919 0.08773421258689686 0.06911465239807621 9.568875416494513e-08 7.019139099747651 -0.32736478559137483 EESPMDVDQPS(ph)PSAQDTQSIASDGTPQGEK ddPTM_A459_Selumetinib_30min_R1 1 EESPMDVDQPSPSAQDTQSIASDGTPQGEK 30 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 EES(0.001)PMDVDQPS(0.466)PS(0.466)AQDT(0.061)QS(0.003)IAS(0.004)DGTPQGEK 70.889 0.001322 0.0 264.6 277.67 262.78 334.9 280.26 334.69 324.76 292.85 232.58 160.82 True False 270.76466517802584 245.16026731471922 227.0959193472175 276.4160018515922 254.91053248392177 331.323322474206 300.2630917342242 285.08266668913706 394.6712730288954 181.46281351945493 1.492122049286956 1.351022077525736 1.2514735936400003 1.52326527121744 1.4047535555079025 1.8258469382691693 1.6546811212206434 1.5710252759779506 2.174942983492219 1.0 7.503530122305879 -6.739513086655075 23.36929378175315 1.6815746355248526 1.3996480787771177 0.1489341252678451 0.28105055576201554 182.0472873973746 194026.6532458818 0.08712696637190234 0.08703142958854414 1.8217421774583694e-07 6.739513086655075 -0.2819265567477349 EESPMDVDQPS(ph)PSAQDTQSIASDGTPQGEK ddPTM_A459_Selumetinib_30min_R2 1 EESPMDVDQPSPSAQDTQSIASDGTPQGEK 30 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 EESPMDVDQPS(0.472)PS(0.472)AQDT(0.053)QS(0.002)IAS(0.001)DGTPQGEK 94.006 1.3585000000000002e-07 4236000.0 33005.0 27272.0 32561.0 33747.0 37112.0 26454.0 28371.0 31672.0 26953.0 28713.0 True False 31170.71422948332 29363.674706698723 30466.060709736288 29150.60038317789 32449.658774510473 30097.79837449762 29690.307716069987 31764.16027641816 32344.35312974259 27883.981084666677 1.117871731975317 1.053066081831684 1.0926008240082148 1.045424621924153 1.1637383727947819 1.0793938743219245 1.0647800838021872 1.1391544191616592 1.1599618085929868 1.0 14.767148933620858 -6.196309329987196 24.999757596723036 1.1052223356890647 1.0766112528377434 0.04957447425781314 0.04942817466656033 588.8735364520878 226034.21406700628 0.014122745817069295 0.01823236602246503 6.36342119299439e-07 6.196309329987196 -0.0286110828513213 EESPMDVDQPSPS(ph)AQDTQSIASDGTPQGEK ddPTM_A459_Selumetinib_30min_R2 1 EESPMDVDQPSPSAQDTQSIASDGTPQGEK 30 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 EES(0.001)PMDVDQPS(0.188)PS(0.809)AQDT(0.001)QSIASDGTPQGEK 114.03 4.0586e-12 3703400.0 60597.0 49611.0 62628.0 69180.0 66723.0 54112.0 50912.0 60166.0 48795.0 57100.0 True False 57229.261329010784 53416.00417549244 58598.58266421068 59757.564657843584 58340.66022881181 61565.436820171446 53279.5088802141 60341.07309898254 58555.36344621345 55451.37463638307 1.0320620851022364 0.9632944994738656 1.0567561768930909 1.0776570472724605 1.0521048506258852 1.1102598848789724 0.960832968156141 1.0881799323220243 1.0559767693801008 1.0 15.7589356047067 -5.284234939600046 23.923566888744666 1.0533692057015456 0.997678291842224 0.18720579828708883 0.0433979538758453 589.1610745051356 618314.2634093453 0.01084976111062189 0.022617533285867273 5.197147711943103e-06 5.284234939600046 -0.05569091385932157 EESREPAPAS(ph)PAPAGVEIR ddPTM_A459_Selumetinib_30min_R1 2 EESREPAPASPAPAGVEIR 19 1 Q14195-2 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 EES(0.021)REPAPAS(0.979)PAPAGVEIR;EESREPAPAS(1)PAPAGVEIR 131.48 0.0012645999999999998 70075000.0 2638.7 2957.2 3329.8 3474.8999999999996 3863.3 2873.5 4112.2 3569.1000000000004 2279.05 2601.7 True False 2700.1765759835876 2610.9696492350163 2877.631449282156 2868.073946951621 3513.8651971210143 2844.59519892925 3802.0134432487853 3474.435873929316 3867.3813947738613 2935.6535377040536 0.9197872096634978 0.8893997931639543 0.9802353759812965 0.9769797117117281 1.1969618185493287 0.9689819191518017 1.2951165368861284 1.1835306276116762 1.3173834531572493 1.0 11.519465997757967 -6.20159933123431 0.8561807422269585 1.1985790324839207 0.8922124865137091 0.501143072516904 0.1066017498499371 0.4964456696911207 0.7723339268880747 0.05183075633816761 0.09281608952384929 6.286380564457035e-07 6.20159933123431 -0.3063665459702116 EESREPAPAS(ph)PAPAGVEIR ddPTM_A459_Selumetinib_30min_R2 4 EESREPAPASPAPAGVEIR 19 1 Q14195-2 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 EES(0.002)REPAPAS(0.998)PAPAGVEIR;EESREPAPAS(1)PAPAGVEIR;EES(0.001)REPAPAS(0.999)PAPAGVEIR;EESREPAPAS(1)PAPAGVEIR 106.74 0.00044517 159700000.0 231945.0 203155.0 207899.0 268438.0 245338.0 171468.0 195948.0 237155.0 190219.0 236255.0 True False 219054.42544940175 218736.3352537176 194523.00468331613 231876.28131862165 214516.44709045204 195086.16056847197 205059.9702635962 237845.0817868765 228268.11516293217 229433.7042857919 0.9547613160468293 0.9533749016284494 0.8478397072864692 1.0106461125248938 0.9349822762885861 0.8502942546116274 0.8937656779849799 1.0366614727651655 0.9949197127488827 1.0 17.80771781624494 -7.7621850744756165 24.999988063809642 1.0118429563303812 0.9205434582119018 0.428291692607902 0.04749335695276155 19.65143867412385 658737.0248655702 0.024976285473906554 0.01311634404540848 1.729079355491133e-08 7.7621850744756165 -0.09129949811847948 EESS(ph)EDENEVSNILR ddPTM_A459_Selumetinib_30min_R1 1 EESSEDENEVSNILR 15 0 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 EES(0.036)S(0.964)EDENEVSNILR 150.12 0.00027193 10958000.0 1270.4 1302.0 1306.6 1171.1 1397.1 1263.1 1313.8 1289.8 776.58 1149.6 True False 1299.997848231913 1149.561234716621 1129.1708966400574 966.5893692696313 1270.7325516780384 1250.3943608030395 1214.6990082535522 1255.5903141391473 1317.7995408409142 1297.162358052266 1.0021859177165027 0.8862122983916422 0.870493111082522 0.7451568134624247 0.9796249049240737 0.9639459185976917 0.936427888701199 0.9679515492759592 1.0159094832351099 1.0 10.341143349060843 EESS(ph)EDENEVSNILR ddPTM_A459_Selumetinib_30min_R2 1 EESSEDENEVSNILR 15 0 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 EES(0.016)S(0.984)EDENEVSNILR 225.7 1.2612999999999998e-10 4158000.0 17470.0 18160.0 18410.0 19336.0 20057.0 18799.0 17550.0 18520.0 14822.0 15338.0 True False 16499.087337951023 19552.81360639662 17225.520643292435 16702.403443539497 17537.260348144977 21388.391609668884 18366.109774665274 18573.89013384896 17786.814161282422 14895.152087090093 1.1076816968019474 1.312696472790191 1.1564514778081465 1.1213315141653224 1.1773804151583553 1.435929722947012 1.2330259984779561 1.2469755276918117 1.1941344443672104 1.0 13.862555233863343 -8.702007304761796 4.30273145376867 1.0000031843759147 1.2268395258930067 0.3456689978951579 0.09180080471230123 2.348191900497375 55.52329813816058 0.09121858286135331 0.023822877186447676 1.9860615118482743e-09 8.702007304761796 0.22683634151709198 EEST(ph)SSGNVSNR ddPTM_A459_Selumetinib_30min_R2 1 EESTSSGNVSNR 12 0 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 EES(0.079)T(0.4)S(0.4)S(0.12)GNVSNR 123.95 0.007419199999999998 2544600.0 11359.0 9582.5 10344.0 12433.0 11847.0 9881.3 7470.9 9335.6 9248.9 10992.0 True False 10727.71225367978 10317.446937406137 9678.478301695652 10739.603951878702 10358.673946476227 11242.359381489505 7818.311653307509 9362.76505040822 11098.938435857837 10674.632399354165 1.0049725229253634 0.9665388513079254 0.906680243366621 1.0060865376992718 0.9704009992047076 1.0531846869190258 0.732419755623672 0.8771042130663613 1.0397490068631632 1.0 13.381898768387233 EESYS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 EESYSPSK 8 0 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 EES(0.007)YS(0.69)PS(0.303)K 106.2 0.013829 5153200.0 32080.0 21077.0 29622.0 30824.0 28756.0 30913.0 33811.0 36553.0 31219.0 27041.0 True False 30297.122026414945 22693.538126763306 27716.152769995013 26625.718025634153 25143.41419809826 35170.985149725726 35383.278495225495 36659.36317832508 37463.67233174173 26260.25606904439 1.1537253081903194 0.8641780973916118 1.0554410702288175 1.013916922806422 0.9574702596954999 1.3393237696255869 1.347407976609007 1.3960017404986071 1.4266301224649494 1.0 14.680593363858668 -6.76534343883198 24.994488300190476 1.3294688388541112 1.0037628184865235 0.5537047209538475 0.13027855401316904 65.54621106275113 419635.3585158474 0.042260590521486556 0.03865399148203761 1.7165504071411717e-07 6.76534343883198 -0.32570602036758767 EESYS(ph)PSKDR ddPTM_A459_Selumetinib_30min_R1 1 EESYSPSKDR 10 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 EES(0.138)YS(0.843)PS(0.019)KDR 160.52 0.0020918000000000004 44809000.0 3942.8 5220.6 4653.3 4970.0 3766.0 4130.8 4135.0 4610.2 2478.4 3816.9 True False 4034.659568646715 4609.3697250089035 4021.4074187472665 4102.082798454505 3425.365964941304 4089.247902466309 3823.0936208924018 4487.922519959913 4205.663784825932 4306.836294754432 0.936803558928112 1.0702449337633162 0.9337265555333953 0.9524584910391627 0.7953322881376461 0.9494783694116403 0.8876802736962138 1.0420462290210653 0.9765088563845058 1.0 12.072412771642254 -10.005847602943852 8.532811658862101 1.000000749992627 0.9489354649513997 0.042553031351998394 0.07203001349107815 0.0 0.0 0.07271071175529696 0.017634937922407595 9.866256389240614e-11 10.005847602943852 -0.051065285041227204 EESYS(ph)PSKDR ddPTM_A459_Selumetinib_30min_R2 2 EESYSPSKDR 10 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 EES(0.062)YS(0.726)PS(0.212)KDR;EESYS(0.994)PS(0.006)KDR 122.18 0.02158 16661700.0 70990.0 68822.0 65964.0 69054.0 64583.0 53016.0 60119.0 57935.0 47754.0 59826.0 True False 67044.6599954861 74100.42610239147 61719.948056172834 59648.72607520566 56469.5061606545 60318.47276866885 62914.652623538495 58103.58125834443 57306.13435824317 58098.66793338451 1.1539792972940275 1.2754238391034103 1.062329830469443 1.02667975354613 0.9719587069604075 1.038207499659537 1.0828932032602874 1.0000845686335795 0.9863588339744717 1.0 15.826217465934315 -5.405413167765061 4.548519376626699 1.01875936330281 1.2130829186468506 0.7913448273689592 0.04026940346768239 0.09201727962061473 2.9845418555702046 0.010737582689992423 0.023309558950100142 3.9317584808175845e-06 5.405413167765061 0.19432355534404055 EET(ph)YDVPPAFAK ddPTM_A459_Selumetinib_30min_R2 1 EETYDVPPAFAK 12 0 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4;H3BN62 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 EET(0.68)Y(0.32)DVPPAFAK 117.2 0.011283 2827800.0 31102.0 25595.0 27883.0 34156.0 31586.0 32268.0 35685.0 26350.0 28744.0 31917.0 True False 29373.47535117074 27558.054199103597 26089.038136714993 29503.89387761353 27617.88429757727 36712.62410026041 37344.42320848604 26426.67413752267 34493.60317446376 30995.473279674938 0.9476698447586599 0.8890993194536764 0.8417047838344413 0.9518775084154143 0.8910296044967154 1.1844511541733564 1.2048347470459302 0.8525978583734605 1.1128593799237998 1.0 14.919769912667473 -6.736598342299248 24.987807726496225 1.070103886386622 0.9026013049156679 0.42545258518058204 0.09683134884674287 232.4813375206954 233854.33265762974 0.032827909782520585 0.03281420420275897 1.8340098241359799e-07 6.736598342299248 -0.16750258147095398 EETEELKR ddPTM_A459_Selumetinib_30min_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 127.46 0.006191899999999999 5421700.0 2228.9 2409.9 1901.9 1939.5 2903.5 1612.5 2080.2 2123.3 1319.1 1804.7 False True 2280.829033315578 2127.747787667885 1643.6324263888905 1600.8027339240473 2640.878937654559 1596.2797140328578 1923.2888392213722 2066.983186549582 2238.4163567478554 2036.350824266635 1.1200570187295642 1.0448827197711206 0.8071460019571152 0.7861134313634563 1.296868352046184 0.7838922915493881 0.9444781401623266 1.015042772550736 1.0992292340166836 1.0 10.99177041622733 -7.963645036418096 5.240540155312712 1.0524277622958162 0.9646742146390925 0.04310067242444238 0.15352346903852226 0.6162729197289889 42.19878712277928 0.09135352188108432 0.04096938269710676 1.0873139590410517e-08 7.963645036418096 -0.08775354765672372 EETGDEEDGS(ph)PIALHR ddPTM_A459_Selumetinib_30min_R2 2 EETGDEEDGSPIALHR 16 0 P79522-2 P79522-2 PRR3 Proline-rich protein 3 1 EET(0.057)GDEEDGS(0.943)PIALHR;EETGDEEDGS(1)PIALHR 156.96 0.00025752 9994600.0 50096.4 35482.1 43711.6 43776.1 51895.6 49347.9 46610.1 56296.9 57126.0 35148.9 True False 47312.24263977844 38203.46297706636 40899.24324559158 37813.71966201539 45376.01077544957 56145.125289365365 48777.56200616102 56460.71465854652 68552.79623380229 34134.05992919029 1.3860713533029985 1.119218254620689 1.198194511008517 1.1078002364927702 1.3293470178929856 1.644841703736272 1.4289997177994083 1.6540872892258338 2.0083399506537534 1.0 15.058924399358723 -6.602393238431356 4.094897910602399 1.5797546740104156 1.1977050175138317 0.3014991092798175 0.24566921581608672 0.2472960399861602 7.9935308762031925 0.08038460774743687 0.08091698499888696 2.4980824112741955e-07 6.602393238431356 -0.38204965649658384 EETNGPSNQKPVKS(ph)PDNSIK ddPTM_A459_Selumetinib_30min_R2 1 EETNGPSNQKPVKSPDNSIK 20 2 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 EETNGPSNQKPVKS(0.683)PDNS(0.317)IK 88.28299999999999 0.0022641 3420300.0 10427.0 9320.0 8374.0 9651.7 8703.4 10156.0 11031.0 9477.2 7829.9 8792.6 True False 9847.509082588165 10034.814031476682 7835.225956921829 8337.121809888818 7610.001082616796 11554.89681301118 11543.963357511819 9504.777082965085 9396.098785685137 8538.734792081643 1.1532749666519926 1.175210880279643 0.9176097100694344 0.9763884243858013 0.8912328662173576 1.3532328962513933 1.3519524424411284 1.1131364674517468 1.1004087859009941 1.0 13.059806602234623 -6.7574642556017706 24.999750983565853 1.20133003677776 1.0227977705928668 0.26545896597740326 0.13230284250864857 140.0887560283165 881025.5568282872 0.047423108403169316 0.04575056359156026 1.7479771229134404e-07 6.7574642556017706 -0.17853226618489315 EETPGT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 EETPGTPK 8 0 Q99442 Q99442 SEC62 Translocation protein SEC62 1 EET(0.01)PGT(0.99)PK 106.18 0.032362 14775000.0 7501.9 11808.0 8110.6 6790.9 8361.4 10673.0 9625.4 10017.0 5630.8 10911.0 True False 7676.679673843662 10425.513870609728 7009.225068336793 5604.996795980824 7605.1128463250725 10565.639310308648 8899.348328546004 9751.316620198355 9555.056342639546 12311.533132140115 0.6235356386121527 0.8468087409352127 0.5693218702420353 0.4552639168349057 0.6177226479187548 0.858190381076611 0.722846475173237 0.7920473035760155 0.7761061307381292 1.0 13.587722808667642 -6.7532815878482895 24.88251166710945 0.8101540434524453 0.6227417935406532 0.4506835601636927 0.11339888257384785 188.32390509610576 574415.8238006397 0.03955590054437303 0.03889881821624901 1.7648931282539912e-07 6.7532815878482895 -0.18741224991179217 EETPGT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 EETPGTPK 8 0 Q99442 Q99442 SEC62 Translocation protein SEC62 1 EET(0.039)PGT(0.961)PK;EET(0.243)PGT(0.757)PK 107.55 0.030992 37281000.0 660110.0 178504.0 421650.0 452070.0 213160.0 271930.0 995760.0 622390.0 527770.0 331030.0 True False 623423.728829699 192194.68281917478 394521.49805780884 390497.2861357518 186380.93512542176 309385.88916523504 1042064.8130610074 624201.0518577892 633338.7471258952 321472.30378076923 1.9392766390688763 0.5978576709682697 1.2272332434798368 1.2147151762164081 0.5797729164641375 0.9624029365099626 3.2415383869947703 1.9416946483933135 1.9701191663397726 1.0 18.294334922971906 -7.187664549541755 24.999902630683884 2.116834285692488 1.053787228198058 0.35768831446888383 0.6201182595116782 131.7007301837005 44628.69014284943 0.2261278315840248 0.17515785051557434 6.49135634415958e-08 7.187664549541755 -1.0630470574944302 EETY(ph)DVPPAFAK ddPTM_A459_Selumetinib_30min_R1 2 EETYDVPPAFAK 12 0 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4;H3BN62 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 EET(0.249)Y(0.751)DVPPAFAK;EET(0.015)Y(0.985)DVPPAFAK 227.88 1.1172e-08 12775800.0 5444.0 6459.3 4336.3 3724.3 5144.799999999999 5141.8 5132.299999999999 5469.9 3486.0 4886.7 True False 5570.834607820002 5703.0421531528955 3747.4542775909076 3073.920918769438 4679.453748388216 5090.078160380865 4745.166478961566 5324.820483260753 5915.487392633631 5513.955545488874 1.0103154735038917 1.034292370713565 0.6796308469800428 0.5574801779612281 0.8486564154868118 0.9231264413339719 0.8605739454761697 0.965698841663158 1.072821016388727 1.0 12.428871920787616 -7.747422907417833 1.4044546851105804 1.0395330340481423 0.8266345007242272 0.25132869556857573 0.1353708338753615 0.6822806509138166 2.494718556548486 0.1236028547380555 0.04844904829245463 1.788863045994688e-08 7.747422907417833 -0.21289853332391517 EETY(ph)DVPPAFAK ddPTM_A459_Selumetinib_30min_R2 2 EETYDVPPAFAK 12 0 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4;H3BN62 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 EET(0.131)Y(0.869)DVPPAFAK;EET(0.075)Y(0.925)DVPPAFAK 155.42 0.0067572000000000005 2538600.0 32769.0 30115.0 34387.0 35765.0 36622.0 35646.0 34608.0 35973.0 28872.0 30441.0 True False 30947.830164700474 32424.723665012876 32174.57785773476 30893.74530193371 32021.21695516604 40555.91293782954 36217.34057445102 36077.67547434927 34647.20675108254 29562.08923478349 1.0468756087877067 1.0968346454641351 1.0883729361007866 1.0450460742667458 1.0831851802101011 1.3718892672210206 1.2251279091545666 1.2204034426599113 1.1720148219536453 1.0 14.851460611893813 -6.5650382479657505 24.999370381797362 1.214939722139999 1.0715514431304138 0.33767784133479684 0.08662682993013969 142.17562369571155 84305.11926978422 0.02724207676519346 0.02724209383254973 2.722461532521951e-07 6.5650382479657505 -0.14338827900958506 EEVGAGYNS(ph)EDEYEAAAAR ddPTM_A459_Selumetinib_30min_R2 3 EEVGAGYNSEDEYEAAAAR 19 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 EEVGAGY(0.051)NS(0.949)EDEYEAAAAR;EEVGAGYNS(1)EDEYEAAAAR;EEVGAGYNS(1)EDEYEAAAAR 225.83 4.221e-52 29986000.0 80119.0 66208.0 77181.0 84293.0 89131.0 76610.0 99189.0 92655.0 94814.0 66707.0 True False 75666.30672176869 71285.94070772603 72215.25848831909 72812.14798646446 77933.56693875 87162.33210366148 103801.48503927489 92924.61071013896 113779.4493245064 64780.99558439949 1.1680324767961825 1.1004144049446047 1.1147599359480964 1.1239738958874388 1.2030313247843616 1.3454923209709337 1.6023447016036951 1.4344424606607467 1.7563708044015716 1.0 15.983283019859746 -6.830272244590947 2.4216374901456583 1.4846152207392567 1.1279877979905661 0.3857145226637808 0.18204562912180033 0.2587462336030254 3.101999948334811 0.06653868028933586 0.058951340321625974 1.478181475466778e-07 6.830272244590947 -0.3566274227486905 EEVILS(ph)PVPSVLK ddPTM_A459_Selumetinib_30min_R2 2 EEVILSPVPSVLK 13 0 Q4G0A6 Q4G0A6 FAM188B Protein FAM188B 1 EEVILS(1)PVPSVLK;EEVILS(0.82)PVPS(0.18)VLK 135.02 0.0011691 2167850.0 22387.0 14453.6 18366.699999999997 21244.0 23711.0 15902.3 24934.0 24607.0 26678.0 18180.7 True False 21142.820162261552 15562.144644350996 17185.006518150945 18350.530552055927 20732.212200970516 18092.697478293398 26093.4804057837 24678.60229609186 32014.345445600597 17655.775951868472 1.1975016119313664 0.8814194678713109 0.9733362365380658 1.0393499896057488 1.1742453153851033 1.0247466623736061 1.4779005169139725 1.3977636759419898 1.8132505494448454 1.0 14.107852606895204 -7.261057243405451 24.981286152067 1.4553756733990029 1.0427340299963892 0.4454874501926185 0.20290135851977759 28.60174104871193 1869864.8811250573 0.07701132183924951 0.05590557966024013 5.482047024961838e-08 7.261057243405451 -0.41264164340261367 EEVVGGDDS(ph)DGLR ddPTM_A459_Selumetinib_30min_R2 2 EEVVGGDDSDGLR 13 0 P25490 P25490 YY1 Transcriptional repressor protein YY1 1 EEVVGGDDS(1)DGLR;EEVVGGDDS(1)DGLR 206.67 1.2013e-05 26118000.0 81521.0 56899.0 79723.0 90352.0 107364.0 80470.0 106991.0 113958.0 108183.0 67978.0 True False 76990.38917441931 61262.970340878936 74593.70897583938 78045.90173410626 93875.97447366205 91554.01206607031 111966.29349864445 114289.59891323764 129822.62288557683 66015.29851194491 1.166250716271298 0.9280117142815603 1.1299457952514185 1.1822396246528295 1.4220336284122987 1.3868605327824788 1.6960658517417002 1.7312592912468296 1.9665535991189453 1.0 16.01051277568297 -6.47949827954307 1.1245732678977365 1.6485226901911127 1.0488050377338627 0.4404432663203326 0.24371701257974934 0.39367510044234083 1.0507908209000754 0.10869703095057098 0.12980972278594594 3.315138831009858e-07 6.47949827954307 -0.5997176524572501 EEVVTVETWQEGS(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 EEVVTVETWQEGSLK 15 0 P09211;A8MX94;A0A087X2E9 P09211 GSTP1 Glutathione S-transferase P 1 EEVVTVET(0.001)WQEGS(0.999)LK 190.19 2.7127e-05 3338400.0 39643.0 28323.0 29035.0 30866.0 29118.0 21107.0 38272.0 37989.0 27308.0 24241.0 True False 37439.80076350271 30495.283027201065 27166.91971091776 26661.997553180114 25459.936521777203 24014.29765973091 40051.72383452928 38099.541700582515 32770.36304927135 23541.09934431807 1.5904015448003817 1.2954060717882945 1.1540208600102961 1.1325723222698736 1.0815100921751246 1.020100943821345 1.7013531631944048 1.6184266139541312 1.3920489680606558 1.0 14.522894073823965 -7.256608632865723 24.99850452821478 1.4794927355967713 1.2038884073379497 0.1619610606147036 0.228074409390392 597.9444164796784 3094298.030866441 0.08982882908194573 0.06727463056390422 5.53848988808731e-08 7.256608632865723 -0.27560432825882164 EEYEAHQDR ddPTM_A459_Selumetinib_30min_R2 1 EEYEAHQDR 9 0 Q06587;Q06587-2 Q06587 RING1 E3 ubiquitin-protein ligase RING1 0 109.83 0.015742 3258200.0 21657.0 20546.0 19378.0 22073.0 22353.0 21227.0 26257.0 38523.0 22728.0 32018.0 False True 20453.390639840032 22121.812134197393 18131.240577171127 19066.619321951144 19544.816301644547 24150.82657047935 27478.002527258443 38635.09555217401 27274.235073379205 31093.557147245436 0.6578015677968833 0.711459677303507 0.583118891521788 0.6132016105992636 0.6285809053331813 0.7767148176746597 0.8837201352400655 1.2425434429780793 0.8771667694442421 1.0 14.92432805203841 -7.248185513926083 2.091293700389038 1.044181512704973 0.6410773210241558 0.7666258741012008 0.09523822159336248 0.14260396954900892 1.2193154895712701 0.04493356852938582 0.029179692695436906 5.6469570696367204e-08 7.248185513926083 -0.4031041916808171 EFAPS(ph)DEELDSYR ddPTM_A459_Selumetinib_30min_R1 2 EFAPSDEELDSYR 13 0 I3L0X5;I3L4C3;O75391 I3L0X5 SPAG7 Sperm-associated antigen 7 1 EFAPS(0.999)DEELDS(0.001)YR;EFAPS(1)DEELDSYR 276.32 1.7548999999999994e-39 37626000.0 4453.3 5385.4 5533.9 5316.8 5096.4 4995.4 4951.3 4201.1 2291.54 3112.0 True False 4557.053225386632 4754.874864395461 4782.426775536823 4388.320688696761 4635.431519842503 4945.1508114603 4577.819454685501 4089.673180903992 3888.576012540351 3511.4555134469842 1.2977676088834307 1.3541036889651172 1.361949982627632 1.2497155871381127 1.3200883514233046 1.4082908903510338 1.3036814611932053 1.1646660950830063 1.107397202570045 1.0 11.777853442477062 -8.077115228551088 1.519822526633001 1.0195029784781517 1.33297167831673 0.8717049886303143 0.043598663835557536 0.13600887378133916 0.5632690866249539 0.04146358116446124 0.013382064163759684 8.373070953665181e-09 8.077115228551088 0.3134686998385783 EFAPS(ph)DEELDSYR ddPTM_A459_Selumetinib_30min_R2 2 EFAPSDEELDSYR 13 0 I3L0X5;I3L4C3;O75391 I3L0X5 SPAG7 Sperm-associated antigen 7 1 EFAPS(1)DEELDSYR;EFAPS(1)DEELDSYR 188.92 0.00015217 21875000.0 43650.0 39626.0 47597.0 51885.0 59010.0 41218.0 41096.0 38957.0 36146.0 44192.0 True False 41224.10774479462 42665.18678232774 44534.66083969529 44818.17349338268 51596.63624390661 46895.40536024956 43007.04543017914 39070.358420321485 43376.21000362395 42916.06213539475 0.9605752646815026 0.994154278361432 1.0377154525313637 1.0443216656734957 1.202268653659922 1.092723866702879 1.002120028964851 0.910390107486084 1.0107220431077177 1.0 15.389230083827183 -7.4912723000027714 7.23705725775413 0.9675428215245184 1.0572256478245183 0.24547163259296412 0.0650799062196157 0.30823021437928944 57.41197695448018 0.03108506448668948 0.02022195656150837 3.22647050996674e-08 7.4912723000027714 0.08968282629999991 EFAPS(ph)DEELDSYRR ddPTM_A459_Selumetinib_30min_R2 1 EFAPSDEELDSYRR 14 1 I3L0X5;I3L4C3;O75391 I3L0X5 SPAG7 Sperm-associated antigen 7 1 EFAPS(1)DEELDSYRR 115.04 0.001466 2350300.0 6137.2 6608.1 9481.1 7128.3 9079.4 4339.7 4439.6 5775.4 5817.4 7622.7 True False 5796.118993158158 7114.920021609551 8871.096348241163 6157.413242996623 7938.764601134142 4937.454283125699 4646.050196900508 5792.205457831057 6981.042551736899 7402.612844846889 0.7829828622191091 0.9611363137223087 1.198373673481589 0.8317891766125423 1.0724273668668867 0.6669880468708778 0.6276230155862763 0.7824541927602131 0.9430511493784991 1.0 12.853818862562063 -6.758942661221682 24.993755430288928 0.7794016530142851 0.9739681829337062 0.22231398014796422 0.1510081865413031 89.57456469897843 896701.104447937 0.051411303945953224 0.04915038093212215 1.7420368548342305e-07 6.758942661221682 0.19456652991942114 EFCENLSADCR ddPTM_A459_Selumetinib_30min_R2 1 EFCENLSADCR 11 0 C9J9C1;P30153;B3KQV6 C9J9C1 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 139.15 0.043847 0.0 9450.9 8733.8 9749.0 11577.0 11145.0 10661.0 8674.3 10135.0 10284.0 8925.3 False True 8925.656812950272 9403.654376406763 9121.759953908631 10000.192628561075 9744.86546243585 12129.455979077606 9077.672137799367 10164.49117206043 12341.087358968314 8667.603398285635 1.029772176091453 1.0849197805089594 1.0523970161939833 1.1537436785050654 1.1242860355566437 1.3994013594896013 1.0473105102610993 1.1726991539634664 1.4238177258328706 1.0 13.081417426508905 -6.0233078649824545 1.7874294300026548 1.2083569461614503 1.055655388808377 0.19137855786580116 0.12704863293054508 0.5716356118347707 3.6651285613565676 0.04117303925420872 0.06620304071196179 9.477463816183166e-07 6.0233078649824545 -0.15270155735307323 EFDEDS(ph)DEKEEEEDTYEK ddPTM_A459_Selumetinib_30min_R2 2 EFDEDSDEKEEEEDTYEK 18 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 EFDEDS(0.981)DEKEEEEDT(0.016)Y(0.003)EK;EFDEDS(1)DEKEEEEDTYEK 107.63 0.00086674 36401100.0 116937.0 45576.2 69291.0 83791.0 77293.0 81553.0 209126.0 180929.0 122717.0 50867.9 True False 110438.1096759003 49071.74798941921 64832.89249833653 72378.52125246284 67582.76233181279 92786.18548557506 218850.77337530744 181455.4734355915 147263.82899946667 49399.21155632349 2.2356249461589504 0.9933710770559381 1.3124276776040447 1.4651756368609048 1.3680939473043403 1.8782928423823737 4.430248307218029 3.673246347843051 2.981096749521212 1.0 15.592200395188156 -7.070064244972434 7.14006568105828 3.241696378560554 1.4553950515962193 0.4073671790614348 0.8686164562613138 0.2227944143227045 19.67207007752968 0.31652641116962676 0.24585506486631198 8.510121390768121e-08 7.070064244972434 -1.7863013269643349 EFET(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 EFETPEK 7 0 Q9Y2X3;F8WED0 Q9Y2X3 NOP58 Nucleolar protein 58 1 EFET(1)PEK 111.46 0.035038 8876000.0 3938.6 5506.4 4068.7 4305.8 4429.0 4079.5 4701.4 4711.2 2295.7 4078.7 True False 4030.36171681849 4861.708128144087 3516.192887769324 3553.872859876341 4028.39773200346 4038.4639338896354 4346.769612881144 4586.243671865677 3895.6352287059763 4602.240874902379 0.8757389772442062 1.0563784600359953 0.7640175695592875 0.7722048794222932 0.8753122319111359 0.8774994711625775 0.9444898107323307 0.996524040468212 0.8464648710479782 1.0 12.168120778857055 -7.239197621726071 4.585495103371652 0.9471217644310912 0.8689590675539711 0.16644484657969105 0.08424114752866166 0.41419347887101116 22.804389079351033 0.036111345565257066 0.026320373405809675 5.765040708001748e-08 7.239197621726071 -0.07816269687712007 EFGYDSPHDLDS(ph)D ddPTM_A459_Selumetinib_30min_R2 2 EFGYDSPHDLDSD 13 0 Q96CW6 Q96CW6 SLC7A6OS Probable RNA polymerase II nuclear localization protein SLC7A6OS 1 EFGYDSPHDLDS(1)D;EFGYDSPHDLDS(1)D 85.973 0.02709 4426700.0 40462.0 43156.0 52913.0 54401.0 49126.0 26034.0 30683.9 36550.0 37210.0 42329.0 True False 38213.2840222195 46465.926431588785 49508.63518731844 46991.489953040575 42954.35268798776 29619.94718687801 32110.76214899437 36656.354448821774 44653.03973426789 41106.851786050094 0.9296086263455343 1.1303693767022396 1.204388880106833 1.143154678874909 1.0449438675467877 0.7205598555939463 0.7811535243837717 0.8917334423859083 1.0862675635359949 1.0 15.32709126527829 -6.5599744855138225 10.896875171076134 0.881926933141206 1.1091114915197882 0.41583160513616724 0.11614568980520007 0.5271489111274491 152.13602622088902 0.04005792392456975 0.04009922819500688 2.7543905170322976e-07 6.5599744855138225 0.2271845583785822 EFHGNIIK ddPTM_A459_Selumetinib_30min_R2 1 EFHGNIIK 8 0 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 97.635 0.028254 3028500.0 89747.0 85073.0 81859.0 81791.0 86034.0 69178.0 71949.0 76554.0 61642.0 74734.0 False True 84759.22102570641 91597.8255471907 76592.28106134015 70650.92470265529 75225.63976628137 78706.64156464032 75294.77106423878 76776.75946580298 73972.12242138514 72576.23523774858 1.1678646701368327 1.2620911686467384 1.0553355490324845 0.9734718874740985 1.0365051248504933 1.084468508276979 1.037457658386174 1.0578774059345202 1.0192333920196308 1.0 16.147209601085628 -5.3282224295002285 6.100859019297836 1.0341793003381177 1.2144187186556559 0.8045913741590406 0.03591791236130931 0.081443730298303 5.778877363419173 0.009364689560699331 0.019995547403044007 4.696535079172905e-06 5.3282224295002285 0.1802394183175382 EFHLNES(ph)GDPSSK ddPTM_A459_Selumetinib_30min_R1 2 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 EFHLNES(1)GDPSSK;EFHLNES(0.842)GDPS(0.127)S(0.031)K 140.75 0.00057234 32547000.0 8109.0 9876.0 10652.5 11360.7 9363.5 8644.2 10202.099999999999 9234.9 5184.9 7633.4 True False 8297.923922632704 8719.713328772163 9205.94900999404 9376.767011750924 8516.573078260191 8557.247196305632 9432.547383242172 8989.960452817186 8798.396609887011 8613.221245612534 0.9633937972810767 1.0123637928392788 1.0688160384459453 1.0886481078757069 0.9887790915156656 0.9935013802953901 1.0951242414731877 1.0437396412400943 1.0214989675748551 1.0 13.07233717454305 -4.877258436677431 3.4800088769278905 1.039735391697427 0.9611406423114421 0.27861582465084556 0.03610357053706739 0.34108510380160073 7.009196827278881 0.009526113011915551 0.06076322292394588 1.3266047968457099e-05 4.877258436677431 -0.07859474938598487 EFHLNES(ph)GDPSSK ddPTM_A459_Selumetinib_30min_R2 3 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 EFHLNES(0.911)GDPS(0.071)S(0.018)K;EFHLNES(0.72)GDPS(0.248)S(0.033)K;EFHLNES(0.997)GDPS(0.002)S(0.001)K 131.84 0.00098163 41178300.0 193927.0 213276.0 220890.0 228716.0 241458.0 182630.0 182190.0 195691.0 148841.0 207563.0 True False 183149.31369128975 229633.58340957286 206678.17788684805 197564.4862428934 211123.88737809195 207785.62474992414 190662.19600263637 196260.42841161118 178613.35896501364 201570.11687655986 0.9086134221147926 1.139224340233919 1.0253413605619743 0.9801278547845489 1.04739676024191 1.030835462962849 0.9458852282126551 0.9736583549822502 0.8861103110556573 1.0 17.620922247056548 -7.261814342858104 24.92158679091487 0.9492183333629655 1.0266685432573521 0.2445091006865867 0.06032450837267631 43.862512162680986 2915112.4557280857 0.02313664594358495 0.016692409067423565 5.472498574863023e-08 7.261814342858104 0.07745020989438667 EFHLNESGDPS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 EFHLNES(0.069)GDPS(0.792)S(0.14)K 78.069 0.027678 3638000.0 11529.0 13438.0 13352.0 16119.0 14383.0 12560.0 10853.0 14260.0 14477.0 14058.0 True False 10888.264334243693 14468.651390019697 12492.94685655842 13923.564393174047 12576.078954348573 14290.025991671962 11357.686004811514 14301.494239129917 17372.804521177008 13652.109012929483 0.7975518159085722 1.0598107132251062 0.9150928142111041 1.0198837688731812 0.9211821369458861 1.0467266250319514 0.8319363692492499 1.047566659890089 1.272536316896076 1.0 13.736836219153425 -7.999951961673469 24.999928259605497 1.1441959527644214 0.9506696954285389 0.3749392390368441 0.10142530437182203 1.4591303774934399 759332.7236895151 0.05119909824757137 0.024195660260871523 1.0001106184523322e-08 7.999951961673469 -0.19352625733588258 EFHLNESGDPSSK ddPTM_A459_Selumetinib_30min_R2 2 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 ; 137.93 0.0014255 26146000.0 315510.0 289120.0 340250.0 367420.0 374790.0 310240.0 258460.0 312700.0 256420.0 355340.0 False True 297975.2172866017 311294.57433267584 318358.68543618935 317376.76216514775 327705.5295348882 352972.74392168096 270478.9021287742 313609.90522972855 307711.1649734196 345080.4109158036 0.8634950227855875 0.9020928586080443 0.9225637717055633 0.919718280509944 0.9496497603709106 1.022870996892962 0.7838141301934655 0.9088023988305916 0.8917085851288681 1.0 18.3965730534645 -4.794844064022295 2.214975674872272 0.920808595948796 0.8495059127428949 0.08440069270777217 0.06106714449670671 1.8391980284624434 10.81977900706437 0.01634364394108495 0.25984024885137313 1.603821148697395e-05 4.794844064022295 -0.07130268320590116 EFIPPNPWS(ph)SSGLS(ph)GKS(ph)SGTMS(ph)VISK ddPTM_A459_Selumetinib_30min_R2 2 EFIPPNPWSSSGLSGKSSGTMSVISK 26 1 Q9UPZ9 Q9UPZ9 ICK Serine/threonine-protein kinase ICK 4 EFIPPNPWS(0.725)S(0.23)S(0.23)GLS(0.712)GKS(0.712)S(0.362)GT(0.362)MS(0.333)VIS(0.333)K;EFIPPNPWS(0.586)S(0.344)S(0.357)GLS(0.674)GKS(0.674)S(0.236)GT(0.208)MS(0.46)VIS(0.46)K 46.578 0.026418 22711000.0 19358.2 17050.5 11014.8 10307.7 9331.4 8485.5 19522.9 17848.7 11355.9 8205.0 True False 18282.34874101452 18358.21852400141 10306.11976000747 8903.773478225701 8159.106108225559 9654.300601300354 20430.75353389245 17900.63676198866 13627.397310356693 7968.100330849795 2.294442587555209 2.303964277774539 1.2934224384833175 1.1174273802443595 1.0239713067663385 1.211618855239832 2.5640683080748206 2.2465375709042514 1.7102441917800673 1.0 12.960020097970208 -7.238067329967251 24.835780098871247 1.9840908597128355 1.5215148453332255 0.0670107481438108 0.5672055767031018 1646.9838371875453 1750132.1469122267 0.2326414670441413 0.18009333422514984 5.780064304003715e-08 7.238067329967251 -0.46257601437961005 EFITGDVEPTDAES(ph)EWHS(ph)ENEEEEKLAGDMK ddPTM_A459_Selumetinib_30min_R1 1 EFITGDVEPTDAESEWHSENEEEEKLAGDMK 31 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 2 EFIT(0.003)GDVEPT(0.3)DAES(0.848)EWHS(0.848)ENEEEEKLAGDMK 44.931 0.024096 3220300.0 844.78 837.41 1124.6 1105.0 1100.2 1101.3 1050.2 681.83 482.29 638.21 True False 864.4617303442659 739.3656478986527 971.8854969856184 912.032493418959 1000.6871042560861 1090.2219219003944 970.9825684791298 663.745653504027 818.410904932092 720.1304701918377 1.2004237650352156 1.0267106843870817 1.3495964095599438 1.2664822989311921 1.3895913944448288 1.5139227779237932 1.3483425693964413 0.9217019428815584 1.1364758732040223 1.0 9.492114501394228 -7.754769638438318 24.998959426972093 1.021816666336331 1.3012120711062138 0.49473981806188116 0.12960720298021453 141.65462965395776 530943.6802682076 0.06931815082768247 0.03883682914132869 1.7588563116218134e-08 7.754769638438318 0.2793954047698828 EFITGDVEPTDAES(ph)EWHSENEEEEK ddPTM_A459_Selumetinib_30min_R1 6 EFITGDVEPTDAESEWHSENEEEEK 25 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPT(0.03)DAES(0.85)EWHS(0.12)ENEEEEK;EFIT(0.011)GDVEPT(0.145)DAES(0.742)EWHS(0.102)ENEEEEK;EFITGDVEPT(0.006)DAES(0.828)EWHS(0.165)ENEEEEK;EFITGDVEPT(0.012)DAES(0.561)EWHS(0.426)ENEEEEK;EFITGDVEPT(0.02)DAES(0.957)EWHS(0.023)ENEEEEK;EFITGDVEPT(0.009)DAES(0.971)EWHS(0.02)ENEEEEK 138.12 2.1452e-08 95698600.0 8024.02 9873.45 5874.35 6251.54 5295.77 7027.9400000000005 8249.44 8941.15 5504.52 10087.76 True False 8210.964053975 8717.461883957623 5076.645535494813 5159.825894939696 4816.768538544131 6957.2453044589665 7627.178099137754 8704.001657051655 9340.768405765824 11382.622259103457 0.7213596188178988 0.7658570833259161 0.44599964928421254 0.4533073115742756 0.423168618697843 0.6112163916266996 0.6700721437925062 0.7646745590709972 0.820616567355152 1.0 13.47454533476907 -8.119033404659907 1.02737914252345 0.9807881196696729 0.5619161505559974 0.6213907007155672 0.10900442757582499 0.37077029925454136 0.7552515236971185 0.11501005840060897 0.0406550818473215 7.602677971183183e-09 8.119033404659907 -0.4188719691136755 EFITGDVEPTDAES(ph)EWHSENEEEEK ddPTM_A459_Selumetinib_30min_R2 3 EFITGDVEPTDAESEWHSENEEEEK 25 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPTDAES(1)EWHSENEEEEK;EFITGDVEPT(0.022)DAES(0.867)EWHS(0.111)ENEEEEK;EFITGDVEPT(0.001)DAES(0.825)EWHS(0.174)ENEEEEK 148.64 4.9281e-10 43215400.0 181768.0 131880.0 159039.0 191738.0 197339.0 160991.0 226189.0 246243.0 195938.0 153617.0 True False 171666.06223495584 141994.77193896376 148806.60388857065 165622.95363350122 172547.51058695637 183166.0489192085 236707.23668500056 246959.52636227672 235131.0749651435 149181.67806510086 1.150718134166872 0.9518244718831972 0.9974857892645065 1.1102097508329785 1.1566266905220022 1.227805259297843 1.586704478425995 1.6554279960204425 1.5761390943902338 1.0 17.186710834508844 -6.975370564008744 2.2392373701324955 1.5075911523487382 1.0565465221538706 0.48195894122161875 0.18167568463171735 0.22629917229178767 2.287577056491626 0.07420060326306543 0.05940299298723565 1.0583502969500597e-07 6.975370564008744 -0.4510446301948676 EFITGDVEPTDAES(ph)EWHSENEEEEKLAGDMK ddPTM_A459_Selumetinib_30min_R1 1 EFITGDVEPTDAESEWHSENEEEEKLAGDMK 31 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPT(0.037)DAES(0.878)EWHS(0.085)ENEEEEKLAGDMK 56.332 0.0013724 3010000.0 426.96 658.0 759.6 874.66 705.1 695.94 614.53 574.92 460.97 733.36 True False 436.9073372804607 580.9610541040989 656.4504921841329 721.9170504016532 641.323829495516 688.9394754629627 568.1755073390585 559.671253996649 782.2324220832829 827.4938995313238 0.5279885900402606 0.7020729148977942 0.7932994944807853 0.8724137432439475 0.7750194048061854 0.832561395139184 0.6866219891903275 0.6763448701115934 0.9453029472801237 1.0 9.69260486586576 -14.52287503366119 0.03479349632544455 2.201368958081925 5.912884992647398e-09 0.4601785887349311 0.0975449875538217 1228.5388649107758 3.194912517563744 169.1617956844129 59.2101948452588 3.000025639066318e-15 14.52287503366119 -2.20136895216904 EFITGDVEPTDAES(ph)EWHSENEEEEKLAGDMK ddPTM_A459_Selumetinib_30min_R2 2 EFITGDVEPTDAESEWHSENEEEEKLAGDMK 31 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPT(0.026)DAES(0.526)EWHS(0.448)ENEEEEKLAGDMK;EFIT(0.001)GDVEPT(0.067)DAES(0.48)EWHS(0.452)ENEEEEKLAGDMK 49.793 0.0099183 20128600.0 36780.0 33087.0 33878.0 39994.0 36008.0 30338.0 22573.0 26118.0 22757.4 36174.0 True False 34735.91484200563 35624.66650852667 31698.32636357746 34546.74820650183 31484.353124395682 34516.78411905604 23622.68922755095 26193.999055932334 27309.515894883843 35129.56262866061 0.9887944011482277 1.0140936534023948 0.9023262458074623 0.9834095736312044 0.8962352721894986 0.9825566143227575 0.6724447291660349 0.7456397716310262 0.7773941333560257 1.0 15.100397994328056 -7.244389429646356 24.721359096065186 0.7776729701645945 0.9590141937335128 0.45447654481533917 0.08587968990497431 552.29020733767 800787.1045964835 0.03121571442975507 0.024112443422240087 5.6965323804164366e-08 7.244389429646356 0.18134122356891835 EFITGDVEPTDAESEWHS(ph)ENEEEEK ddPTM_A459_Selumetinib_30min_R1 1 EFITGDVEPTDAESEWHSENEEEEK 25 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPTDAES(0.34)EWHS(0.66)ENEEEEK 128.33 4.3837e-08 206090000.0 3721.3 4686.3 2540.5 2545.5 3181.6 3150.2 4072.3 4069.0 1547.3 4322.3 True False 3807.9990496106884 4137.625817398236 2195.5140539676004 2100.976209952905 2893.8248417571026 3118.5118481527493 3765.1231323724614 3961.076902025267 2625.6550896792933 4877.109307767316 0.7807901790402861 0.8483766830504755 0.4501670796000021 0.430783088377141 0.5933483666540708 0.639418075618315 0.771998922881655 0.812177183668373 0.5383629777371727 1.0 12.251810591669173 -7.201850713575884 4.325191833864258 0.7654948918231181 0.6139419106431566 0.18671618221211772 0.15892677710615935 0.44540485163133076 17.13581585664986 0.06751516246767765 0.0504790868222862 6.282742876522273e-08 7.201850713575884 -0.15155298117996152 EFITGDVEPTDAESEWHS(ph)ENEEEEK ddPTM_A459_Selumetinib_30min_R2 4 EFITGDVEPTDAESEWHSENEEEEK 25 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPTDAES(0.001)EWHS(0.999)ENEEEEK;EFITGDVEPT(0.006)DAES(0.011)EWHS(0.982)ENEEEEK;EFITGDVEPT(0.001)DAES(0.031)EWHS(0.968)ENEEEEK;EFIT(0.003)GDVEPT(0.16)DAES(0.16)EWHS(0.676)ENEEEEK 112.39 9.1591e-08 279620900.0 129755.0 99487.0 123634.0 142155.0 140073.0 120977.0 162874.0 160829.0 143298.0 120896.0 True False 122543.73655041981 107117.33299887531 115679.52304252124 122793.24376894675 122475.77747149182 137640.48363013522 170447.9637287083 161296.98576332562 171961.60408065352 117405.41835446893 1.043765596749865 0.9123712900154918 0.9852996962479458 1.0458907731005307 1.0431867556718253 1.1723520563128769 1.4517895861849748 1.37384618209306 1.4646820094918385 1.0 16.841139465957504 -6.933282026503776 2.598395495340122 1.3530644345115643 0.9977699681860178 0.571603996389223 0.12764492045503384 0.17849488632969182 2.4441909179885273 0.048441998350332006 0.04045968664149038 1.1660521485092869e-07 6.933282026503776 -0.3552944663255465 EFITGDVEPTDAESEWHS(ph)ENEEEEKLAGDMK ddPTM_A459_Selumetinib_30min_R1 10 EFITGDVEPTDAESEWHSENEEEEKLAGDMK 31 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPTDAES(0.016)EWHS(0.984)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.066)EWHS(0.933)ENEEEEKLAGDMK;EFITGDVEPT(0.005)DAES(0.205)EWHS(0.789)ENEEEEKLAGDMK;EFITGDVEPT(0.004)DAES(0.089)EWHS(0.907)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.002)EWHS(0.998)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.04)EWHS(0.96)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.012)EWHS(0.988)ENEEEEKLAGDMK;EFITGDVEPT(0.005)DAES(0.193)EWHS(0.802)ENEEEEKLAGDMK;EFITGDVEPT(0.006)DAES(0.062)EWHS(0.932)ENEEEEKLAGDMK;EFITGDVEPT(0.01)DAES(0.281)EWHS(0.709)ENEEEEKLAGDMK 130.48 1.8116999999999998e-18 940810500.0 21971.85 25771.56 32225.24 32811.95 27444.199999999997 24088.31 24284.86 22364.56 11383.44 18571.350000000002 True False 22483.75135522227 22754.21377432681 27849.22940857265 27081.958889084355 24961.876955667056 23846.003471835545 22453.033458347043 21771.379218470924 19316.86626643757 20955.163672767867 1.072945633177796 1.0858523526541044 1.3289912616986101 1.292376395240402 1.191204103459525 1.137953577658019 1.0714797464228696 1.038950568864502 0.9218189162388011 1.0 14.355018169401106 -7.469002168222299 1.3674570859819335 0.9702925142239601 1.1996375938488744 0.582077410140668 0.0776896621337187 0.34894050076599087 1.2461782772525194 0.06030879739894704 0.029468027800921046 3.396235770099169e-08 7.469002168222299 0.22934507962491424 EFITGDVEPTDAESEWHS(ph)ENEEEEKLAGDMK ddPTM_A459_Selumetinib_30min_R2 7 EFITGDVEPTDAESEWHSENEEEEKLAGDMK 31 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 EFITGDVEPT(0.039)DAES(0.177)EWHS(0.784)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.023)EWHS(0.976)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.003)EWHS(0.997)ENEEEEKLAGDMK;EFITGDVEPTDAES(0.051)EWHS(0.949)ENEEEEKLAGDMK;EFITGDVEPT(0.004)DAES(0.123)EWHS(0.873)ENEEEEKLAGDMK;EFITGDVEPT(0.014)DAES(0.187)EWHS(0.798)ENEEEEKLAGDMK;EFITGDVEPT(0.013)DAES(0.078)EWHS(0.908)ENEEEEKLAGDMK 124.1 2.9189e-17 272487100.0 418598.1 404761.1 423629.2 462594.7 433644.7 310323.7 291962.4 308476.4 211516.2 459296.0 True False 395334.0933829629 435804.97485793225 396373.35848459887 399588.5038396312 379166.37595319434 353067.97283692786 305539.23011252057 309374.0152529825 253825.3502564194 446034.9310856787 0.8863298944338136 0.9770646747266049 0.8886599027564943 0.8958681842854913 0.8500822458686771 0.7915702296623651 0.6850118876761911 0.6936093872736504 0.569070565030841 1.0 18.766797173216247 -6.743770394886666 1.5976789743960504 0.7115893396245576 0.9171658276863003 0.3481885073457044 0.10547425619601307 0.35672815952127973 1.8898120065550745 0.043361538621794385 0.039979394421264206 1.8039712218785586e-07 6.743770394886666 0.20557648806174267 EFLEDYDDDRDDPK ddPTM_A459_Selumetinib_30min_R2 2 EFLEDYDDDRDDPK 14 1 P49756 P49756 RBM25 RNA-binding protein 25 0 ; 109.44 0.012869 21294800.0 147925.0 117753.0 131919.0 126283.0 121987.0 105963.0 131080.0 125236.0 89158.0 122215.0 False True 139703.92069069293 126784.27646442867 123431.47516254717 109083.0375496744 106661.90248238322 120558.44141365743 137175.47973009248 125600.41602606403 106992.0912826623 118686.33539729544 1.1770851313509882 1.0682297674793468 1.0399805061751015 0.9190867439332879 0.8986873014937975 1.0157735598634436 1.1557815756203589 1.0582550687543273 0.9014693302688355 1.0 16.85679431852057 -4.85623640582537 1.8219513308661879 0.9998808082832229 1.215664945412678 0.35769752345574957 0.07455990825781762 0.9264832890841184 3.6265398980389847 0.022816427386016684 0.3306559106660343 1.3923986520274058e-05 4.85623640582537 0.2157841371294551 EFLSNPPAGFPS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 EFLSNPPAGFPSSR 14 0 Q14674;H3BRX7 Q14674 ESPL1 Separin 1 EFLSNPPAGFPS(0.5)S(0.5)R 91.202 0.011429 33297000.0 4621.0 6559.2 5521.1 6041.6 6026.4 5646.6 6368.9 5208.1 3088.5 4734.2 True False 4728.660309099238 5791.2458147106445 4771.364945231454 4986.547974877814 5481.313184047335 5589.800330702592 5888.488745369192 5069.964269707002 5240.958924884959 5341.880685013082 0.885205153002712 1.0841211468759082 0.893199460373153 0.9334817209354429 1.0261017621425799 1.0464105546919198 1.1023250223258723 0.9490972503244118 0.981107447717568 1.0 12.38313203729885 -6.2701641836489985 24.201757697045107 1.0206479512049247 0.9546673604866907 0.2156453213931001 0.0634699207082876 698.5146534788174 1937607.9712075326 0.01985648927650306 0.022879935284304626 5.368288115772431e-07 6.2701641836489985 -0.06598059071823403 EFNAEVHR ddPTM_A459_Selumetinib_30min_R1 4 EFNAEVHR 8 0 A0A2R8Y6J3;P46777 A0A2R8Y6J3 RPL5 60S ribosomal protein L5 0 ;;; 173.39 0.00017689 62788000.0 39396.200000000004 44961.6 37736.1 37534.6 39658.2 35338.3 41177.8 37906.6 21316.4 36472.1 False True 40314.05480833916 39697.474969919254 32611.744889559814 30979.886721704326 36071.122812223904 34982.828786609185 38071.72539356302 36901.19383001005 36172.37391174282 41153.64930333858 0.9795985408533064 0.9646161553575471 0.7924387130089626 0.752785894960501 0.8764987655492716 0.8500541113317795 0.925111771083554 0.8966688119932162 0.8789590844087877 1.0 15.328732746973815 -7.266082942272107 24.152013758376604 0.9165739862835834 0.865196185315237 0.12393099914974104 0.07078338417208385 667.6918305830939 3472755.839504903 0.03169228362982235 0.022176548666483806 5.418973880668921e-08 7.266082942272107 -0.05137780096834643 EFNAEVHR ddPTM_A459_Selumetinib_30min_R2 4 EFNAEVHR 8 0 A0A2R8Y6J3;P46777 A0A2R8Y6J3 RPL5 60S ribosomal protein L5 0 ;;; 148.94 0.0021016 69741200.0 285278.0 235199.0 286942.0 295397.0 323740.0 248407.0 270284.0 270802.0 263442.0 244980.0 False True 269423.3908183167 253238.00701601733 268480.4641188282 255163.41901175192 283068.8869276792 282622.809435769 282852.7415575859 271589.98898631526 316137.7611844936 237906.79086551897 1.1324745705582362 1.0644421123698171 1.1285111414519964 1.07253524829389 1.1898310506306182 1.1879560411351457 1.1889225209946757 1.141581490794167 1.3288303374374717 1.0 17.860036927402803 -6.269545417766704 24.030461085167236 1.1814912239104973 1.0990601763481935 0.17136263473262225 0.07764863302407451 552.9868800204296 1639334.1089612276 0.02230823530906675 0.02574803341274471 5.375942095086476e-07 6.269545417766704 -0.0824310475623038 EFPGFLENQKDPLAVDK ddPTM_A459_Selumetinib_30min_R1 1 EFPGFLENQKDPLAVDK 17 1 P60903 P60903 S100A10 Protein S100-A10 0 123.76 0.0037689 30773000.0 1455.5 1426.7 1506.1 1695.6 1341.8 1718.1 1389.5 1249.1 773.91 1243.8 False True 1489.4103180900097 1259.6613007451642 1301.5798924151152 1399.4952903540152 1220.4344269140304 1700.8174739099861 1284.6888963071328 1215.969810351379 1313.268745849998 1403.4538456379687 1.061246383498253 0.8975438021423208 0.9274119675973066 0.9971794189767929 0.8695935607054159 1.211879877059188 0.9153766618688848 0.8664123969097359 0.9357406016106107 1.0 10.454765904434078 EFPGFLENQKDPLAVDK ddPTM_A459_Selumetinib_30min_R2 1 EFPGFLENQKDPLAVDK 17 1 P60903 P60903 S100A10 Protein S100-A10 0 83.37 0.037617000000000005 7360200.0 17161.0 15841.0 14016.0 18686.0 13672.0 8445.5 17197.0 13358.0 8930.4 14872.0 False True 16207.260320926014 17055.953763156867 13114.22581946696 16140.934564852041 11954.401130769224 9608.790964384203 17996.694575209043 13396.869568464059 10716.729536224288 14442.606717903493 1.122183871477647 1.1809470476000563 0.9080234666509452 1.117591504090688 0.8277176941992186 0.6653086352114577 1.2460835448008007 0.9275936006660691 0.742021834807667 1.0 13.818043534488615 -5.39119002818762 1.250824988027524 0.9157963858752921 1.1745173103155568 0.2135157097230881 0.16283060800537807 1.0311647999517723 2.6440935344918852 0.0540821708352409 0.2600735030160439 4.0626552632078095e-06 5.39119002818762 0.25872092444026473 EFS(ph)GGSYSAK ddPTM_A459_Selumetinib_30min_R1 1 EFSGGSYSAK 10 0 H0Y7V8;A0A0A0MRJ1;H0Y5V1;A0A0A0MRJ0;Q5VT25-3;Q5VT25-4;Q5VT25-5;Q5VT25;Q5VT25-2;Q5VT25-6 H0Y7V8 CDC42BPA Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase MRCK alpha 1 EFS(0.959)GGS(0.04)YS(0.001)AK 102.4 0.015329 17096000.0 2154.4 2318.4 2396.2 2270.0 2237.7 2014.8 1749.8 1772.3 993.73 1689.0 True False 2204.5933282673427 2046.96065020508 2070.8092013844366 1873.5871131774102 2035.3004300980235 1994.5329412920316 1617.8111772279387 1725.2928467582644 1686.2872308324208 1905.7996022531984 1.1567812930913015 1.0740691979287795 1.0865828699597533 0.9830976514856526 1.0679509155588647 1.0465596377152797 0.8488884011284422 0.9052855529608026 0.8848187547309532 1.0 10.896180710292255 -7.172615638568208 5.690830707591121 0.9023262800731647 1.0678416623910656 0.6823148455443167 0.05329690617137239 0.1312824322930228 6.639265908337357 0.020612386900990678 0.0158547095550444 6.720233472138174e-08 7.172615638568208 0.16551538231790086 EFS(ph)GGSYSAK ddPTM_A459_Selumetinib_30min_R2 1 EFSGGSYSAK 10 0 H0Y7V8;A0A0A0MRJ1;H0Y5V1;A0A0A0MRJ0;Q5VT25-3;Q5VT25-4;Q5VT25-5;Q5VT25;Q5VT25-2;Q5VT25-6 H0Y7V8 CDC42BPA Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase MRCK alpha 1 EFS(0.942)GGS(0.056)YS(0.002)AK 83.182 0.04078 11114000.0 49051.0 38231.0 38399.0 56173.0 44435.0 28134.0 49138.0 46606.0 37138.0 39764.0 True False 46324.941786710675 41163.19476795976 35928.45014567007 48522.140496170075 38852.678046059824 32009.203124976044 51423.014365099814 46741.61574396133 44566.637722419786 38615.910000720454 1.1996335651767986 1.0659646442927742 0.9304053729408358 1.256532359208026 1.0061313599843937 0.8289123090554865 1.3316535688046822 1.21042377981224 1.1541004140932665 1.0 15.236907749064615 -7.284634988802572 24.991460357358886 1.1915797212326045 1.0509896144945765 0.16363958301835257 0.13730315559164527 1389.8222926891635 1497418.2369575163 0.05735485571915278 0.03869625948843265 5.19236257744888e-08 7.284634988802572 -0.14059010673802796 EFS(ph)GPSTPTGTLEFEGGEVSLEGGK ddPTM_A459_Selumetinib_30min_R2 1 EFSGPSTPTGTLEFEGGEVSLEGGK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 EFS(0.32)GPS(0.291)T(0.291)PT(0.049)GT(0.049)LEFEGGEVSLEGGK 56.298 0.045042 0.0 11715.0 8898.7 13971.0 16264.0 14811.0 12506.0 14724.0 13305.0 14419.0 11851.0 True False 11063.927198860685 9581.201676169689 13072.121070474668 14048.815143035084 12950.30976798002 14228.587981835157 15408.6951750525 13343.715347238684 17303.202900521603 11508.830837404132 0.9613424122025068 0.8325086893301468 1.1358339743764228 1.2206987261795446 1.1252498147675458 1.2363191520368613 1.3388584290398695 1.159432746536782 1.5034718248082632 1.0 13.490453659522379 -5.425589279971927 3.437113705291835 1.2322824100688579 0.8975199328489945 0.5023964248018372 0.12869338467541958 0.1820665150402687 3.9819504936794705 0.0333359673566968 0.07588844600535667 3.7532778863094886e-06 5.425589279971927 -0.3347624772198634 EFSGPS(ph)TPTGTLEFEGGEVSLEGGK ddPTM_A459_Selumetinib_30min_R1 1 EFSGPSTPTGTLEFEGGEVSLEGGK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 EFS(0.007)GPS(0.496)T(0.496)PT(0.001)GTLEFEGGEVSLEGGK 164.3 5.835599999999998e-14 44642000.0 9961.2 10160.0 7724.1 6986.1 8538.5 7958.9 9763.0 9331.0 5361.9 8448.3 True False 10193.276578878887 8970.462476744147 6675.209645444256 5766.108780338638 7766.194182594616 7878.8406921030155 9026.569049763611 9083.511568640388 9098.75268231849 9532.721598410715 1.069293430385956 0.9410179856967283 0.7002417490674583 0.6048753989941296 0.8146880303196296 0.8265048560126383 0.9469036682313802 0.9528770430214579 0.9544758638325728 1.0 13.218672448007897 -7.271092695253587 3.399663526613392 0.9633689016512463 0.8133580647992207 0.2430135953797915 0.11815105876901545 0.40252753285757675 9.886264975602328 0.057948317991072924 0.039786232292027 5.356823099699521e-08 7.271092695253587 -0.15001083685202565 EFSGPST(ph)PTGTLEFEGGEVSLEGGK ddPTM_A459_Selumetinib_30min_R1 1 EFSGPSTPTGTLEFEGGEVSLEGGK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 EFS(0.01)GPS(0.146)T(0.688)PT(0.154)GT(0.002)LEFEGGEVSLEGGK 171.0 3.5907e-16 44350000.0 8147.6 9778.5 7116.5 6030.3 8020.4 6469.9 8674.0 8325.7 4653.4 7678.9 True False 8337.423227530175 8633.628674098678 6150.118388136359 4977.221307750546 7294.95623611663 6404.818680199182 8019.713196522534 8104.875390315004 7896.479929111113 8664.561613820062 0.9622440925611172 0.9964299475149389 0.7098014489650415 0.57443429103347 0.8419302165825796 0.739197084129846 0.9255763365720675 0.9354051308709775 0.9113536588528782 1.0 13.080911042291362 -7.35077057402928 6.550006410905249 0.9394894461110047 0.7999566330246046 0.2571171227589404 0.11573845072150653 0.41403908614171586 25.489882368475794 0.05443030167283053 0.03646228946897646 4.458917386767313e-08 7.35077057402928 -0.1395328130864001 EFSGPST(ph)PTGTLEFEGGEVSLEGGK ddPTM_A459_Selumetinib_30min_R2 2 EFSGPSTPTGTLEFEGGEVSLEGGK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 EFS(0.006)GPS(0.208)T(0.708)PT(0.076)GT(0.001)LEFEGGEVSLEGGK;EFS(0.194)GPS(0.122)T(0.552)PT(0.122)GT(0.01)LEFEGGEVSLEGGK 113.02 1.6492e-07 3368400.0 80880.0 57222.0 68288.0 86870.0 76859.0 69340.0 92966.0 78482.0 72504.0 65017.0 True False 76385.01338829298 61610.74340227022 63894.424426352634 75038.1561408913 67203.28529182213 78890.95559415073 97289.1032086342 78710.36962660546 87006.82593102296 63139.79027554673 1.2097761657893242 0.9757831493167204 1.011951800085376 1.1884448113213428 1.0643571193148094 1.2494649609994704 1.5408524922882596 1.2466048633216482 1.378003087297546 1.0 15.946261848167861 -6.873536936840879 4.581924468382862 1.3220241247265305 1.0852260269543372 0.30400763993751234 0.14327253055686925 0.22401042403730492 7.979788667178939 0.04938534262646053 0.04356283177436698 1.3380214113002539e-07 6.873536936840879 -0.2367980977721933 EFSGPSTPT(ph)GTLEFEGGEVSLEGGK ddPTM_A459_Selumetinib_30min_R2 1 EFSGPSTPTGTLEFEGGEVSLEGGK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 EFS(0.187)GPS(0.045)T(0.187)PT(0.291)GT(0.291)LEFEGGEVSLEGGK 63.979 0.0034646 5927600.0 28243.0 24359.0 28836.0 35020.0 30861.0 26958.0 32875.0 34439.0 28316.0 29126.0 True False 26673.36712568693 26227.256973469994 26980.72315426293 30250.21558713039 26983.96527915952 30671.219799641134 34403.75264057666 34539.211788316636 33979.991215144546 28285.056701563804 0.9430197509277835 0.9272478132249938 0.9538861257708293 1.0694769293306008 0.954000749012734 1.0843612626714447 1.2163225622480216 1.22111163335257 1.201340749416489 1.0 14.787752442628818 -6.963349052926601 3.327530822496347 1.1771810413221933 0.9718623316996364 0.6187011358736578 0.06996298700375424 0.15031204068955334 3.4556446929495146 0.026598951267960226 0.022224657162433367 1.0880552456269924e-07 6.963349052926601 -0.20531870962255683 EFTGS(ph)PPSSATK ddPTM_A459_Selumetinib_30min_R1 3 EFTGSPPSSATK 12 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 EFT(0.291)GS(0.694)PPS(0.001)S(0.004)AT(0.01)K;EFT(0.072)GS(0.859)PPS(0.019)S(0.048)AT(0.002)K;EFT(0.286)GS(0.688)PPS(0.02)S(0.005)ATK 141.73 0.00096777 258123000.0 19062.2 25292.0 20110.6 21087.1 19185.7 19247.8 21116.6 19124.3 10386.7 19178.3 True False 19506.312171415582 22330.800882068186 17379.690979618495 17404.633838891343 17450.35682251046 19054.18460760411 19523.7578609278 18617.06143951874 17625.471285446856 21640.021617461516 0.9013998468317506 1.0319213759033066 0.8031272466749606 0.8042798730315222 0.8063927629549881 0.8805067270463874 0.9022060239151477 0.8603069705113638 0.8144849204413324 1.0 14.401414319905903 -5.266329274575353 24.999163894512847 0.8524144974238818 0.9666606120817927 0.30309626220240293 0.06475562645961558 409.1626990084839 2091817.8248565213 0.016324487884528033 0.0358247679044622 5.4159011043039305e-06 5.266329274575353 0.1142461146579109 EFTGS(ph)PPSSATK ddPTM_A459_Selumetinib_30min_R2 3 EFTGSPPSSATK 12 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 EFT(0.003)GS(0.982)PPS(0.01)S(0.006)ATK;EFT(0.325)GS(0.665)PPS(0.01)SATK;EFTGS(0.983)PPS(0.009)S(0.007)ATK 177.36 0.00010365 328086000.0 568618.0 453567.0 591329.0 543428.0 617857.0 440762.0 510755.0 529004.0 441739.0 467229.0 True False 537016.4879182052 488354.1304522296 553283.5359303361 469412.1689344116 540236.2799483374 501472.96466093266 534506.1195418324 530543.3140586737 530099.1432189142 453738.8847632691 1.1835364037587055 1.0762889116435777 1.2193875255346538 1.0345425192714524 1.1906325379853588 1.1052016512152536 1.1780037759397726 1.1692701063861346 1.168291193503252 1.0 18.791502776292695 -10.614679623508103 4.847749510805805 0.9999942416598422 1.1455526736386163 0.39529951397926355 0.05459679691118514 3.1132583257829797e-06 5.831801609889811e-07 0.0484341914947114 0.011746552389707404 2.4284008515500673e-11 10.614679623508103 0.14555843197877416 EFTGS(ph)PPSSATKK ddPTM_A459_Selumetinib_30min_R2 1 EFTGSPPSSATKK 13 1 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 EFT(0.119)GS(0.866)PPS(0.009)S(0.002)AT(0.003)KK 62.055 0.04477 92970000.0 58002.0 64958.0 66623.0 75653.0 67289.0 45035.0 50769.0 51045.0 40721.0 67329.0 True False 54778.48104040272 69940.06972710975 62336.54871363774 65348.93089129579 58835.55424870752 51238.162462973494 53129.859096865 51193.532499045345 48866.337839804415 65385.036828249344 0.8377831335369975 1.0696647600096238 0.9533763646471708 0.9994477951117716 0.8998320885442685 0.7836374337077111 0.8125690780969395 0.7829548621883988 0.7473627026954875 1.0 15.996672896563537 -6.548563328381068 3.8178139812398992 0.8115122666416711 0.9707181140149985 0.3759873537577423 0.08370909708872445 0.20077701058340786 6.408686306077796 0.02655081611513386 0.027600029789677277 2.827721745464631e-07 6.548563328381068 0.15920584737332744 EFTGSPPSS(ph)ATKK ddPTM_A459_Selumetinib_30min_R1 1 EFTGSPPSSATKK 13 1 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 EFT(0.008)GS(0.185)PPS(0.266)S(0.466)AT(0.076)KK 123.28 0.0044621 123530000.0 2638.4 2068.3 3315.1 3467.5 3175.1 2745.2 2639.5 3035.1 1438.5 2508.0 True False 2699.8695865672844 1826.1424744734172 2864.9276285408328 2861.9662180364166 2887.912765609433 2717.58578044217 2440.4003899263575 2954.599288605771 2441.02943611689 2829.9262299887646 0.9540423909134915 0.645296847360105 1.0123683077605197 1.01132184567503 1.0204904760435747 0.9603026932800857 0.8623547723843128 1.0440552327109607 0.8625770559844528 1.0 11.466548730292908 -5.289127198768351 24.968450147022278 0.9721048719994969 0.7996695401057267 0.36237935784543807 0.09126769504504417 615.0521365350344 554643.5647099408 0.02242526339590629 0.04669799659961364 5.138931174454792e-06 5.289127198768351 -0.17243533189377025 EFTGSPPSSAT(ph)KK ddPTM_A459_Selumetinib_30min_R1 1 EFTGSPPSSATKK 13 1 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 EFT(0.001)GS(0.06)PPS(0.218)S(0.218)AT(0.504)KK 133.71 0.022968 0.0 1442.6 1679.8 2175.4 1884.2 1651.7 1868.6 1682.6 2063.8 1188.8 1370.0 True False 1476.2097731890412 1483.1282350821657 1879.992628616853 1555.159840814482 1502.3040266313199 1849.8035805530521 1555.680127330969 2009.0613198328194 2017.3067734833216 1545.852844930066 0.9549484467622948 0.9594239451357751 1.2161523878438139 1.0060206221536159 0.9718286132851692 1.1966233310110037 1.006357191393174 1.2996459051208775 1.304979823984853 1.0 10.594187275338758 -7.755529352364093 24.99986231261304 1.2267346579046716 1.0493889325900536 0.26336996096637333 0.11793891258903755 164.2617762795284 694848.4698562467 0.05601121737599353 0.03124209451928838 1.7557822233367457e-08 7.755529352364093 -0.177345725314618 EFVAVTGAEEDR ddPTM_A459_Selumetinib_30min_R2 1 EFVAVTGAEEDR 12 0 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0;R4GNE6;G3V4V8;R4GMY2 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 0 145.28 0.0095228 2496500.0 12819.0 11096.0 15343.0 17884.0 13024.0 10955.0 15380.0 14824.0 15829.0 12067.0 False True 12106.571298522853 11947.02752073661 14355.848084195308 15448.168348379211 11387.80868396272 12463.951810411336 16095.200474891835 14867.135385754693 18995.242299213278 11718.59435616873 1.0331078054724105 1.0194932222777753 1.2250486404658518 1.3182612076888909 0.9717725810662706 1.0636046808677395 1.3734753491504923 1.2686790696811305 1.6209488716719749 1.0 13.516511908609623 -7.2631966625371165 24.903913279505126 1.338165752849296 1.1103836367661721 0.26281400764914364 0.17099491555040897 197.79995176408974 2803149.1929174284 0.06792377152156683 0.048452631675463896 5.455107802913007e-08 7.2631966625371165 -0.22778211608312393 EFVISDR ddPTM_A459_Selumetinib_30min_R1 1 EFVISDR 7 0 Q14019;H3BT58 Q14019 COTL1 Coactosin-like protein 0 150.84 0.032560000000000006 13257000.0 3696.4 4263.9 3264.8 3820.1 4175.1 3563.3 3841.9 3465.4 1944.2 3079.2 False True 3782.518928057652 3764.68060576667 2821.4580922627133 3152.9912471581592 3797.462942173776 3527.456437217539 3552.102389868565 3373.4863347943865 3299.1654012502304 3474.445313947926 1.0886684308637655 1.0835342811854352 0.812060008812388 0.907480464435773 1.0929695531338823 1.015257434922577 1.02235092767438 0.9709424181326882 0.9495516846979729 1.0 11.762566958414345 -9.380496765070935 0.003090143646561781 3.915962191456246e-06 1.967041064075938 0.007846431641278295 0.08402444912801654 349800.99217531964 355.80546136972424 114400.88572952438 112082.13394289116 4.163928225985974e-10 9.380496765070935 1.9670371481137465 EFVISDR ddPTM_A459_Selumetinib_30min_R2 1 EFVISDR 7 0 Q14019;H3BT58 Q14019 COTL1 Coactosin-like protein 0 151.29 0.031432 12837000.0 74083.0 63381.0 70102.0 81901.0 83200.0 76031.0 72181.0 70521.0 67585.0 81288.0 False True 69965.76343774621 68242.1188979638 65591.71364128648 70745.94251289444 72747.67218256286 86503.58010930018 75537.5595239381 70726.20443461993 81103.88848267941 78941.00422841152 0.8863044513001641 0.864469860308705 0.8308953538455175 0.8961875162899485 0.9215448029020686 1.095800350588482 0.956886224874645 0.8959374804756408 1.0273987425851552 1.0 16.268487251784443 -6.3976672059002695 3.177425454144545 0.9874866068487258 0.8653883129921718 0.5643979452774635 0.05130658324953447 0.20661314888982615 3.937593472333792 0.017415446123560586 0.01990936890329102 4.0025133956965177e-07 6.3976672059002695 -0.12209829385655402 EFVISDRK ddPTM_A459_Selumetinib_30min_R2 2 EFVISDRK 8 1 Q14019;H3BT58 Q14019 COTL1 Coactosin-like protein 0 ; 112.41 0.015132 9390800.0 62411.0 83123.0 77575.0 80236.0 78473.0 55060.0 50016.0 51877.0 43632.0 76378.0 False True 58942.446471028146 89498.2668174287 72583.9089572738 69307.71838517992 68614.52018247903 62644.01521508426 52341.84310482378 52027.95348130034 52359.61917994025 74172.76868612385 0.7946642348009726 1.2066189304077026 0.9785789346010042 0.9344092126110148 0.9250634889043228 0.844568920976569 0.7056746570472275 0.7014427855789839 0.7059143147468301 1.0 16.178602001809317 -6.693401103572368 1.530435497804047 0.7541876935794298 1.0000312371514388 0.3331174525105467 0.12569273955005922 0.3734875383116869 1.8169282814705099 0.052311810345329494 0.050196039257822664 2.025810866769048e-07 6.693401103572368 0.245843543572009 EFVS(ph)SDESSSGENK ddPTM_A459_Selumetinib_30min_R1 2 EFVSSDESSSGENK 14 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 EFVS(0.77)S(0.23)DESSSGENK;EFVS(0.5)S(0.5)DES(0.001)SSGENK 196.37 0.00011754 13142800.0 5228.2 6189.299999999999 6240.0 6795.799999999999 5733.4 5149.7 5292.200000000001 5427.6 3616.4 4538.8 True False 5350.006887693708 5464.6538786724905 5392.6422738664905 5609.041102965212 5214.814982313981 5097.898693553493 4893.005093225339 5283.6424166705165 6136.766668594455 5121.399191655899 1.0446377420471873 1.0670236148699057 1.0529626908702054 1.0952165400626863 1.0182402869142246 0.9954113129590261 0.955403964837837 1.031679472531443 1.1982597799821688 1.0 12.322322300178651 -3.6871755590706448 11.667792194276393 1.0442345582786066 1.051775205062946 0.0 0.06323229192907237 0.0 0.0 0.014789961397409198 0.0 0.00020550596913420667 3.6871755590706448 0.007540646784339522 EFVSPS(ph)LTPPPAIAHPALPTIPER ddPTM_A459_Selumetinib_30min_R2 1 EFVSPSLTPPPAIAHPALPTIPER 24 0 O94763-2;O94763-3;O94763 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 EFVS(0.084)PS(0.481)LT(0.435)PPPAIAHPALPTIPER 58.015 0.007679600000000002 4318300.0 13869.0 13863.0 13483.0 15827.0 17102.0 11993.0 12840.0 12279.0 12212.0 15420.0 True False 13098.216502005886 14926.247523429314 12615.518459180437 13671.335296902143 14953.49386618015 13644.926888385491 13437.085441977328 12314.729857102127 14654.74123178928 14974.784534028498 0.8746848057974841 0.996758750652546 0.8424507498263567 0.9129570623093498 0.9985782321074491 0.9111935372010824 0.8973141090239446 0.8223644105942427 0.9786278526070303 1.0 13.87024762437153 -7.406906578987462 0.00553514646256613 1.8453824108161208 3.290615802374673e-07 0.07790936130631909 0.06074975100511049 20747.07199172398 79.36581450089375 13136.942851355598 13317.162110966026 3.918261537007387e-08 7.406906578987462 -1.8453820817545405 EFVSPSLT(ph)PPPAIAHPALPTIPER ddPTM_A459_Selumetinib_30min_R1 2 EFVSPSLTPPPAIAHPALPTIPER 24 0 O94763-2;O94763-3;O94763 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 EFVSPSLT(1)PPPAIAHPALPTIPER;EFVS(0.028)PS(0.111)LT(0.861)PPPAIAHPALPTIPER 145.66 2.8514e-09 16653300.0 2949.4 3749.7 2737.01 3417.1000000000004 3101.0099999999998 2909.79 3390.1 3059.13 1737.83 2949.5699999999997 True False 3018.115281466629 3310.6833808117635 2365.339075319765 2820.3676319112465 2820.5241930277825 2880.5201544779325 3134.3820276148326 2977.9919349453307 2948.9705839186763 3328.1760407447982 0.9068376325403802 0.9947440701096087 0.7107013109770588 0.8474214096199336 0.8474684507363347 0.8654951298289237 0.9417717059562158 0.8947819762198933 0.8860620795944252 1.0 11.700516030158088 -7.198608876110291 6.801563855278144 0.9218004600834162 0.8596455254376414 0.17510501805868273 0.07176894511094274 0.5265488109012101 47.9518281292834 0.02863514468199166 0.02205075098388205 6.329816555270938e-08 7.198608876110291 -0.06215493464577482 EFVSPSLT(ph)PPPAIAHPALPTIPER ddPTM_A459_Selumetinib_30min_R2 2 EFVSPSLTPPPAIAHPALPTIPER 24 0 O94763-2;O94763-3;O94763 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 EFVS(0.022)PS(0.074)LT(0.904)PPPAIAHPALPTIPER;EFVS(0.015)PS(0.045)LT(0.941)PPPAIAHPALPTIPER 96.579 1.367e-05 7183600.0 26981.7 29571.3 32501.0 34483.9 34076.5 31572.4 28468.5 28407.4 29873.4 36235.9 True False 25482.165130302987 31839.32362328394 30409.92104441323 29787.133331954486 29795.505422224775 35921.21151428851 29792.34165926255 28490.06083090176 35848.914732536374 35189.67541482512 0.7241375440356452 0.9047916256104567 0.8641716834819618 0.8464736596975092 0.8467115729539288 1.0207883730338472 0.8466216669538044 0.809614197774019 1.0187338845823375 1.0 15.102864586459368 -1.5228787453448571 0.0910884453808551 1.0689260183956077 0.3377543804663625 0.3629845009553353 0.07412498817703513 196.98611290266132 1.293213990121319 1.3382718987733782 17.990205960006175 0.029999999995543147 1.5228787453448571 -0.7311716379292452 EFVSPSLT(ph)PPPAIAHPALPTIPERK ddPTM_A459_Selumetinib_30min_R1 1 EFVSPSLTPPPAIAHPALPTIPERK 25 1 O94763-2;O94763-3;O94763 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 EFVS(0.068)PS(0.216)LT(0.716)PPPAIAHPALPTIPERK 61.033 0.0034174 9103300.0 2848.0 2721.3 4073.2 4672.3 4175.7 3654.7 3075.5 3217.1 1867.7 2398.5 True False 2914.352858756683 2402.6889309019525 3520.081812486057 3856.3705149333987 3798.0086722797114 3617.937036202099 2843.5125589007444 3131.7720573864535 3169.3504885891666 2706.370838368441 1.0768490472331669 0.8877899868114283 1.3006649948268614 1.4249231702696903 1.4033585562019186 1.3368223544646245 1.0506736617864905 1.1571851177920869 1.1710702922367566 1.0 11.402143821692357 -8.564653806914666 0.8919879493392977 1.0084249569674195 1.224022045029037 0.13535877686656317 0.1596474831353608 1.5649366545264867 2.7388286325846054 0.17488902940973894 0.060803780846338 2.724872544852093e-09 8.564653806914666 0.2155970880616176 EGAAGS(ph)PGGPR ddPTM_A459_Selumetinib_30min_R1 2 EGAAGSPGGPR 11 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6;P53814-2;H7BZZ8;B5MCI0 A0A087WVP4 SMTN Smoothelin 1 EGAAGS(1)PGGPR;EGAAGS(1)PGGPR 125.36 0.0033649 5317400.0 3029.39 3632.2799999999997 3972.63 4232.85 3767.25 2855.71 3249.15 3325.52 2225.88 2624.98 True False 3099.9688928331807 3207.0109689988385 3433.1686660945898 3493.6622079352423 3426.5029026620064 2826.9841501772225 3004.063999594327 3237.3164067886605 3777.155788157014 2961.9217524704545 1.0466072880715316 1.0827466884714163 1.15910174305958 1.179525490510098 1.1568512570610814 0.95444254994897 1.0142280082479298 1.0929783692254893 1.275238208101411 1.0 11.532317812927625 EGAAGS(ph)PGGPR ddPTM_A459_Selumetinib_30min_R2 2 EGAAGSPGGPR 11 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6;P53814-2;H7BZZ8;B5MCI0 A0A087WVP4 SMTN Smoothelin 1 EGAAGS(1)PGGPR;EGAAGS(1)PGGPR 107.09 0.010744 21586900.0 30657.0 35989.0 33129.0 39641.0 39885.0 29256.0 37626.0 31714.0 31438.0 34632.0 True False 28953.20666969458 38749.240577125995 30997.516208127912 34241.82741546079 34874.28972357592 33285.748440474126 39375.68355450457 31806.282489464666 37726.47845111299 33632.08417525777 0.8608805365382228 1.1521510345657608 0.9216650400432799 1.0181298083409174 1.0369351343748126 0.9897022220514531 1.1707773847531047 0.9457125024937855 1.1217407239622503 1.0 15.037550564781487 -6.555826669812156 1.513359807606187 1.0523495371964615 0.9949225682514695 0.08462342349407714 0.09208381624461771 1.1616769837296732 5.46161616002044 0.03559029454748498 0.038243613387075534 2.780822893606188e-07 6.555826669812156 -0.057426968944991996 EGALCEENMR ddPTM_A459_Selumetinib_30min_R2 1 EGALCEENMR 10 0 P13639 P13639 EEF2 Elongation factor 2 0 147.4 0.01144 23091000.0 29739.0 30762.0 40157.0 43913.0 46009.0 37801.0 32508.0 38440.0 34310.0 38935.0 False True 28086.22543464943 33121.34648458001 37573.34233963574 37931.97364584973 40228.938094321325 43007.74462668726 34019.686413379946 38551.85403591544 41172.958701497744 37810.84538472111 0.742808713978099 0.8759747672281332 0.9937186528714498 1.0032035322113575 1.0639523577163217 1.1374446720005404 0.8997335570583903 1.0195977805747174 1.08891928446898 1.0 15.206512485386373 -4.90016361698046 1.3608925411609998 1.0328708574077103 0.6574434307906553 0.7108951810283516 0.058864613371451796 0.5754578024635861 1.1231322799344374 0.01799110690878869 0.28233022044177203 1.2584512110225753e-05 4.90016361698046 -0.3754274266170551 EGAS(ph)PVTEVR ddPTM_A459_Selumetinib_30min_R2 1 EGASPVTEVR 10 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 EGAS(0.866)PVT(0.134)EVR 131.12 0.0026642 19158000.0 73353.0 75214.0 79793.0 83364.0 97411.0 83112.0 88492.0 107960.0 88756.0 68843.0 True False 69276.33391532466 80982.67194887191 74659.20525204958 72009.6793890788 85173.35931461088 94559.92358438212 92607.05334357146 108274.14572625994 106509.68004984364 66855.32371440508 1.036212676364589 1.2113122403657266 1.116727899949769 1.077097161277571 1.2739951672129721 1.4143963162653512 1.385185923849139 1.6195291520655744 1.5931368533168042 1.0 16.02875482678749 -6.583801011501241 2.2758722178232373 1.4459210409239345 1.1172963372536895 0.39671440103791933 0.16519581975350872 0.277029202892843 2.911303944455452 0.058581407554474746 0.06055057448635066 2.6073479317585214e-07 6.583801011501241 -0.328624703670245 EGASPVT(ph)EVR ddPTM_A459_Selumetinib_30min_R1 1 EGASPVTEVR 10 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 EGAS(0.297)PVT(0.703)EVR 115.23 0.015694999999999997 7038900.0 1861.8 2467.6 1684.0 1812.2 1514.5 1617.1 1951.0 1631.2 1049.4 1759.2 True False 1905.1763175678343 2178.692244843882 1455.3220495498663 1495.7332892070942 1377.5137424066922 1600.833442209323 1803.834499240889 1587.9352771156587 1780.7551548564936 1985.0104560591035 0.9597815022849975 1.0975721755991654 0.7331558607702036 0.753514060664756 0.6939579276280028 0.8064609621188104 0.9087279584522149 0.7999631801780182 0.8971011459515817 1.0 10.954930891458474 -5.259811343672714 24.99997812965717 0.8121881194481525 1.0286768464018943 0.43598836377232086 0.09227458442513717 120.18639552554937 1845534.0141420874 0.02376885578024553 0.05647102432448168 5.497796447572472e-06 5.259811343672714 0.21648872695374177 EGASPVT(ph)EVR ddPTM_A459_Selumetinib_30min_R2 1 EGASPVTEVR 10 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 EGAS(0.407)PVT(0.593)EVR 126.03 0.008246700000000001 19839000.0 81885.0 72073.0 83031.0 95362.0 105820.0 79480.0 101100.0 96223.0 102690.0 72343.0 True False 77334.15951162681 77600.76734877877 77688.87585731728 82373.53109137435 92525.94555719709 90427.64855239555 105801.35032584939 96502.9929994248 123230.86939833265 70254.26962031281 1.1007752258983983 1.1045701246083675 1.1058242620296899 1.1725056930569449 1.317015265509853 1.2871480842532301 1.5059775142158585 1.373624599913606 1.7540694688640328 1.0 16.10029828563564 -6.4537167455382125 1.1768852443427826 1.4336447946990885 1.0962822374649839 0.3357453252782361 0.17642232030707883 0.4781216909330642 1.3849369560228688 0.07449539152724186 0.09047310318873207 3.5178980919135014e-07 6.4537167455382125 -0.3373625572341046 EGCTSETPHALT(ph)VSPFK ddPTM_A459_Selumetinib_30min_R1 1 EGCTSETPHALTVSPFK 17 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 EGCT(0.003)S(0.001)ET(0.002)PHALT(0.575)VS(0.419)PFK 87.228 0.014565 5721900.0 2629.6 2862.3 2232.5 2305.2 3662.9 2307.5 3199.2 2385.7 527.49 1538.0 True False 2690.8645636891033 2527.1805853528294 1929.3387622447012 1902.640093963245 3331.5913417375205 2284.2886450423694 2957.881768309304 2322.423486154259 895.1120036547085 1735.417281388644 1.5505576627287765 1.4562379967373804 1.1117434307793026 1.096358849464028 1.9197638386265534 1.3162763039990764 1.7044210634703776 1.3382507544790065 0.5157906477331256 1.0 10.761066885452696 -8.15691488965881 5.793053623444493 0.7657321947880004 1.4417859603321759 0.5246006436083622 0.259680229870526 0.17220001280750777 7.754658078507963 0.18299450802112044 0.06687597227166553 6.967630480360291e-09 8.15691488965881 0.6760537655441755 EGCTSETPHALTVS(ph)PFK ddPTM_A459_Selumetinib_30min_R1 1 EGCTSETPHALTVSPFK 17 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 EGCTSETPHALT(0.016)VS(0.984)PFK 125.03 0.00084509 6077100.0 2299.2 3194.1 1972.7 2223.0 2894.4 2147.6 2711.7 2111.8 630.06 1938.4 True False 2352.766886535591 2820.1332871031973 1704.8181752654523 1834.7947808781416 2632.6020310478243 2125.9970938647843 2507.1542857978043 2055.788203906845 1069.1658022383092 2187.2125216149198 1.075691942728288 1.2893732361320622 0.7794478855702173 0.8388735720676234 1.2036333941175743 0.972012126327378 1.1462783159025887 0.9399124152731907 0.4888257504345736 1.0 11.094877692054853 -8.013564377576891 23.430471996223122 0.7343981497321475 1.038766543193422 0.28861454887066107 0.18585390066659244 328.02027250810005 566600.5545720612 0.11382264502623773 0.04717148956663008 9.69249582085472e-09 8.013564377576891 0.30436839346127464 EGCTSETPHALTVS(ph)PFK ddPTM_A459_Selumetinib_30min_R2 3 EGCTSETPHALTVSPFK 17 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 EGCTSETPHALT(0.167)VS(0.833)PFK;EGCTSET(0.002)PHALT(0.408)VS(0.589)PFK;EGCTSETPHALT(0.175)VS(0.824)PFK 115.04 0.001109 14693900.0 84749.0 74487.0 101607.0 145785.0 151640.0 116899.0 107392.0 116104.0 119784.0 138748.0 True False 80038.98985712715 80199.91338654555 95069.71624133694 125928.83150684745 132589.6275211999 133000.77614653335 112385.94079321099 116441.84341794821 143744.14704459926 134741.9847294026 0.5940167054676129 0.5952110142032426 0.7055686201465858 0.9345923748989278 0.984026083536433 0.987077460775377 0.8340825691332331 0.8641838225241679 1.066810373420544 1.0 17.039839929714617 -5.645938216108007 2.811398509885057 0.9474418145149586 0.5988416454359882 0.8478963210123739 0.06345770354670173 0.10029312431919934 1.5884056777622906 0.019095266515332665 0.03723452486384618 2.259757226448451e-06 5.645938216108007 -0.3486001690789704 EGDELEDNGKNFY(ph)ESDDDQKEK ddPTM_A459_Selumetinib_30min_R2 1 EGDELEDNGKNFYESDDDQKEK 22 2 O00203-3;O00203 O00203-3 AP3B1 AP-3 complex subunit beta-1 1 EGDELEDNGKNFY(0.988)ES(0.012)DDDQKEK 81.016 0.0031049 31030000.0 50891.0 49055.0 44562.0 29799.0 23831.0 17733.0 25163.0 26830.0 14778.0 32655.0 True False 48062.681952814295 52817.36076331417 41694.929435437116 25740.324793857773 20837.136728156915 20175.559785853413 26333.129359538565 26908.07085805439 17734.012931819696 31712.165302120655 1.515591303681816 1.665523632969401 1.3147928890446625 0.8116861320767796 0.6570707654189571 0.6362088363768788 0.8303794177617262 0.8485094159197951 0.5592179771664405 1.0 14.952748767365858 -5.65854220415381 2.7624402771508394 0.7425115619439757 1.5839717170064682 0.8861330186451339 0.12337058625430138 0.0754316988162052 1.1562361338394638 0.03445662649582048 0.06682767501541184 2.1951176201956764e-06 5.65854220415381 0.8414601550624925 EGDELEDNGKNFYES(ph)DDDQKEK ddPTM_A459_Selumetinib_30min_R1 1 EGDELEDNGKNFYESDDDQKEK 22 2 O00203-3;O00203 O00203-3 AP3B1 AP-3 complex subunit beta-1 1 EGDELEDNGKNFY(0.032)ES(0.968)DDDQKEK 77.445 0.0017690999999999996 29462000.0 592.1 664.55 1090.9 1075.1 400.39 861.69 709.31 701.5 538.55 634.52 True False 605.8947779739573 586.7441770590867 942.7617718847688 887.3539671264464 364.17479519459584 853.0221809519213 655.8061756312428 682.8939412068625 913.880015864269 715.9668227481934 0.8462609700939332 0.8195130813560694 1.3167674002910321 1.2393786121546726 0.5086475848094942 1.1914269681905785 0.9159728562756194 0.9538066842058648 1.2764278830077604 1.0 9.483748925636272 -8.229751916926634 24.319585048266482 1.1382141151629874 0.9789009489254272 0.07445636653461685 0.23110638714766954 1204.4405364571496 924390.4805318417 0.15679044510958712 0.0592473336450971 5.891801180121799e-09 8.229751916926634 -0.1593131662375602 EGDELEDNGKNFYES(ph)DDDQKEK ddPTM_A459_Selumetinib_30min_R2 2 EGDELEDNGKNFYESDDDQKEK 22 2 O00203-3;O00203 O00203-3 AP3B1 AP-3 complex subunit beta-1 1 EGDELEDNGKNFY(0.154)ES(0.846)DDDQKEK;EGDELEDNGKNFY(0.096)ES(0.904)DDDQKEK 71.002 0.0042599 37814400.0 71605.0 69327.0 60306.0 52610.0 41771.8 26220.2 38841.5 35888.3 17314.6 46985.0 True False 67625.48075752621 74644.15797856044 56425.97761620821 45444.42724268791 36524.05303936992 29831.7945467227 40647.706712972125 35992.729011372125 20778.00381034545 45628.4209683093 1.4820911905869967 1.6359136782402286 1.2366410324696144 0.9959675631609259 0.8004671707736125 0.6537985298119791 0.8908418448493655 0.7888225857381842 0.4553741586801037 1.0 15.4776451078321 -5.706422606086049 1.5223229955725592 0.7512302902463036 1.580908713324383 0.8282735076966562 0.14386567906368006 0.1511623644243724 0.7008951463067111 0.0451773438401333 0.10998405298159925 1.965972297567031e-06 5.706422606086049 0.8296784230780795 EGDIIPPLTGAT(ph)PPLIGHLK ddPTM_A459_Selumetinib_30min_R1 2 EGDIIPPLTGATPPLIGHLK 20 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 EGDIIPPLT(0.001)GAT(0.999)PPLIGHLK;EGDIIPPLT(0.001)GAT(0.999)PPLIGHLK 186.55 1.6934e-15 111956000.0 8928.4 9842.4 10827.2 11104.099999999999 9496.4 7352.799999999999 9835.9 8485.8 4768.2 7887.6 True False 9136.414348357848 8690.047232392375 9356.925709552443 9164.977384772366 8637.452296725594 7278.837507808242 9093.970144071485 8260.729018236916 8091.287144450854 8900.050291730211 1.0265576091010702 0.9764042839698369 1.0513340265331705 1.0297669209002471 0.9704947740296908 0.8178422895622989 1.0217886243318717 0.9281665549589824 0.9091282497548527 1.0 13.119597773036041 -6.519577296175377 24.999336898364355 0.9316149712028022 1.017511792480395 0.35551695695689656 0.05416212046181747 149.27722945354802 1130374.4817545505 0.01728384964758648 0.017617451886087845 3.0228925051351e-07 6.519577296175377 0.08589682127759268 EGDPVSLSTPLETEFGS(ph)PSELSPR ddPTM_A459_Selumetinib_30min_R1 1 EGDPVSLSTPLETEFGSPSELSPR 24 0 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 EGDPVSLSTPLETEFGS(0.987)PS(0.013)ELSPR 221.74 1.0609999999999999e-34 12663000.0 3229.5 4401.7 4656.8 4828.8 3962.0 3306.1 3780.5 3631.1 1790.8 2897.9 True False 3304.741066486903 3886.3469177051866 4024.432137971392 3985.540727802236 3603.6377995479124 3272.843635698621 3495.3338413019887 3534.7914325249303 3038.856805142945 3269.8736929363795 1.010663217244704 1.1885312041564542 1.2307607314206108 1.2188668744030844 1.1020724767848171 1.0009082744598536 1.068950720895627 1.0810177286544216 0.9293499047707929 1.0 11.675019193751295 -6.548266037167733 4.3299394331921155 1.0252652216353688 1.1687789070279162 0.49880294298607186 0.06880770017912145 0.18248897633547184 8.039422897262382 0.023556836758949224 0.0243674418113201 2.8296580920227723e-07 6.548266037167733 0.14351368539254739 EGDPVSLSTPLETEFGS(ph)PSELSPR ddPTM_A459_Selumetinib_30min_R2 1 EGDPVSLSTPLETEFGSPSELSPR 24 0 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 EGDPVSLSTPLETEFGS(0.827)PS(0.16)ELS(0.013)PR 131.95 6.734399999999999e-07 0.0 5953.6 3620.0 4898.1 6244.3 5421.9 3392.5 5031.5 5340.8 4734.5 5184.6 True False 5622.722746149124 3897.6423598654037 4582.961578648051 5393.815567981682 4740.752449599008 3859.7860809512035 5265.474719728108 5356.340843782966 5681.5322929828335 5034.907126791449 1.116748056032618 0.7741239831665416 0.910237560145145 1.071284024144245 0.9415769407885992 0.7666052190740003 1.0457938125034674 1.0638410419292788 1.12842841981148 1.0 12.297749451384085 -7.494021511653146 24.788896728816788 1.0686443774248455 0.9271395243714959 0.2601386860891758 0.1071062186901215 823.271056150364 707207.1737655809 0.044693098442826165 0.030060635392996433 3.2061105141859154e-08 7.494021511653146 -0.1415048530533496 EGDPVSLSTPLETEFGSPSELS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 EGDPVSLSTPLETEFGSPSELSPR 24 0 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 EGDPVSLSTPLETEFGSPS(0.064)ELS(0.936)PR;EGDPVSLSTPLETEFGS(0.001)PS(0.033)ELS(0.966)PR;EGDPVSLSTPLETEFGS(0.005)PS(0.069)ELS(0.926)PR;EGDPVSLSTPLETEFGSPS(0.062)ELS(0.938)PR 238.23 8.7143e-45 60549100.0 9064.9 10033.5 11134.3 11917.5 10459.7 9486.599999999999 10954.9 9822.5 5343.27 7898.0199999999995 True False 9276.094532775081 8858.773155552393 9622.323216332 9836.3323441814 9513.621981810029 9391.173417143626 10128.563073159414 9561.975392023385 9067.138932999862 8911.807800229606 1.040876861430527 0.9940489465363194 1.0797274169315108 1.1037415263744774 1.067529977651102 1.0537899411275082 1.1365329347540978 1.0729557466193367 1.017429811801625 1.0 13.12150240326399 -5.272014286593296 24.87811812545879 1.0724882942167449 1.017462903482701 0.1925962843399367 0.03858462674621649 819.0515818875275 1926871.611006559 0.009890754299268209 0.02089215981321916 5.345467746053211e-06 5.272014286593296 -0.05502539073404389 EGDPVSLSTPLETEFGSPSELS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 EGDPVSLSTPLETEFGSPSELSPR 24 0 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 EGDPVSLSTPLETEFGSPS(0.065)ELS(0.935)PR 188.44 2.0135e-26 2208500.0 11793.0 15158.0 14299.0 14757.0 15786.0 11631.0 11987.0 14248.0 9369.5 11104.0 True False 11137.592271119425 16320.569859348003 13379.017907574056 12747.071142755094 13802.821551369436 13233.064674294317 12544.419251789892 14289.459321116616 11243.661805703388 10783.398668343218 1.0328461938271847 1.5134903532093493 1.2407051171029027 1.1821014445266336 1.2800066079250438 1.2271701233807273 1.1633084927682862 1.3251350303004308 1.042682567112293 1.0 13.396524332147393 -8.3586585161199 5.404436260168727 1.0061918238619871 1.2497303295300852 0.3717570470215359 0.11678178980058437 0.22979314603451234 9.73535526509228 0.10594804028364663 0.027651472358328533 4.378662621914762e-09 8.3586585161199 0.2435385056680981 EGDVLTLLES(ph)ER ddPTM_A459_Selumetinib_30min_R1 2 EGDVLTLLESER 12 0 P62857 P62857 RPS28 40S ribosomal protein S28 1 EGDVLTLLES(1)ER;EGDVLTLLES(1)ER 109.44 0.0076377 2431180.0 921.05 1368.91 1067.56 1503.62 1203.9 1112.9699999999998 1138.13 1102.51 698.59 1143.1399999999999 True False 942.5086729486804 1208.6373808110059 922.5912156873258 1241.0409934430913 1095.0074575658082 1101.7745322959067 1052.27993778628 1073.2678533428052 1185.4562070051431 1289.8731541265367 0.7306987279589666 0.9370203395150577 0.7152573202533832 0.9621418892801804 0.8489264654145889 0.8541727756493973 0.815801099836714 0.8320724017778244 0.9190486701833084 1.0 10.333013482938217 -8.515651208317271 2.883983856991781 0.9994477262609358 0.8408034750258122 0.3381028397980984 0.07276262839913647 0.26845305441665135 5.406379584220192 0.06433612021196097 0.017235086023968376 3.0503438059789913e-09 8.515651208317271 -0.1586442512351236 EGDVLTLLES(ph)EREAR ddPTM_A459_Selumetinib_30min_R1 2 EGDVLTLLESEREAR 15 1 P62857 P62857 RPS28 40S ribosomal protein S28 1 EGDVLTLLES(1)EREAR;EGDVLTLLES(1)EREAR 94.845 0.0061608 4358600.0 737.6800000000001 1687.94 1670.7199999999998 2048.55 1459.5700000000002 1295.63 1079.1000000000001 1215.3400000000001 477.78000000000003 837.9200000000001 True False 754.8665087245892 1490.3152000979828 1443.8454006080485 1690.8091985460721 1327.5521512080138 1282.5971385379166 997.7026182116058 1183.1052352193137 810.7577643294596 945.4751940319712 0.7983990627035567 1.5762604979011092 1.5271108218617366 1.788316826521519 1.4041110328306747 1.3565635001678802 1.0552393383869874 1.2513339775462233 0.8575135227736539 1.0 9.884895797165495 -7.223757077296541 1.8209011857509703 1.0352997738098002 1.455326324718819 0.33255616621562656 0.25381831438856217 0.42916285374918284 2.7825153154366884 0.1334177988250157 0.08572292842485103 5.973693318036685e-08 7.223757077296541 0.42002655090901886 EGDVLTLLESER ddPTM_A459_Selumetinib_30min_R1 4 EGDVLTLLESER 12 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 ;;; 238.86 4.1821e-12 38638200.0 8926.9 10549.4 11449.7 12268.1 13064.3 9626.800000000001 11023.8 10180.4 6028.139999999999 8769.6 False True 9134.879401276337 9314.271343716993 9894.893628700192 10125.706635758488 11882.636371689496 9529.963132435048 10192.265890687706 9910.382721400354 10229.313302074152 9895.263583137747 0.9231567531806673 0.941285824825242 0.9999626129779722 1.0232882177098783 1.2008408135725033 0.9630833026696534 1.030014592845821 1.0015279166780733 1.0337585468168478 1.0 13.272522421952152 -5.383013021949066 2.2846419429261537 1.0391186387640228 0.926491990773751 0.32576843564664726 0.059365219884873435 0.37768487261386186 3.746938472682678 0.017168704928275477 0.04980011578203937 4.139872615792204e-06 5.383013021949066 -0.11262664799027178 EGDVLTLLESER ddPTM_A459_Selumetinib_30min_R2 6 EGDVLTLLESER 12 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 ;;;;; 192.5 0.0014357 42027670.0 57734.5 53946.9 64834.5 57472.7 66416.9 47372.9 46855.8 52485.5 45728.8 54350.399999999994 False True 54525.84761951537 58084.45376337651 60663.11885646624 49644.819114062535 58073.01524738053 53898.086966630304 49034.68754300629 52638.224115557714 54875.837769427315 52781.16273270182 1.0330550673096974 1.1004769648128443 1.1493327489521363 0.9405783530286632 1.1002602489353652 1.0211614177502093 0.9290187067558798 0.9972918630484139 1.0396860343401964 1.0 15.687735512142883 -6.263607807017283 0.9907593054954963 0.9947858972869047 1.085051063934256 0.23006292420133545 0.05851850422847138 0.792455337438894 1.6437281569793243 0.027585047458062038 0.04304133944532689 5.449945922556347e-07 6.263607807017283 0.0902651666473514 EGEDGDQPT(ph)TPPKPLK ddPTM_A459_Selumetinib_30min_R1 2 EGEDGDQPTTPPKPLK 16 1 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 EGEDGDQPT(0.919)T(0.081)PPKPLK;EGEDGDQPT(0.971)T(0.029)PPKPLK 238.64 2.429e-20 37356000.0 17179.7 20708.9 12122.2 11711.4 11883.400000000001 14266.7 17674.4 17596.7 9711.1 17696.5 True False 17579.953584122955 18284.29236069358 10476.071822478272 9666.223840205243 10808.54856818467 14123.189951127179 16341.205778258933 17129.978353862876 16479.027429318547 19968.018153507248 0.8804055289300283 0.915678873092474 0.5246425429875834 0.48408528908050075 0.5412930059003488 0.7072905203988176 0.8183689363978623 0.8578707321965305 0.8252710560774463 1.0 14.285403530458952 -7.343340128540604 2.469726615672871 0.8787383478039957 0.6621734971152438 0.3374517991349082 0.13992462656398943 0.418520031473185 4.989495776233355 0.07834589665525649 0.04878675101935135 4.535862401458097e-08 7.343340128540604 -0.21656485068875198 EGEDGDQPT(ph)TPPKPLK ddPTM_A459_Selumetinib_30min_R2 1 EGEDGDQPTTPPKPLK 16 1 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 EGEDGDQPT(0.511)T(0.489)PPKPLK 244.18 6.7020000000000006e-21 11568000.0 60088.0 41257.0 48232.0 56267.0 49877.0 43311.0 59584.0 69005.0 47855.0 40471.0 True False 56748.54951132232 44421.279237836185 45128.80563103097 48603.337534011014 43611.00535396254 49276.69711188729 62354.77406345616 69205.79312560736 57427.337180418996 39302.49707371383 1.4438917050203588 1.1302406346986509 1.148242706980923 1.2366475708363514 1.1096242885577443 1.2537803137410415 1.5865346658892086 1.760849774908917 1.4611625585191472 1.0 15.26233335619157 -7.178678501906911 5.410214287858438 1.5147232385417893 1.205468144923913 0.2162255775339026 0.20259658035435665 0.2516575651519466 12.403642773796216 0.07541864244108758 0.05783638580401584 6.627069086560713e-08 7.178678501906911 -0.3092550936178762 EGEEPTVYS(ph)DEEEPK ddPTM_A459_Selumetinib_30min_R2 1 EGEEPTVYSDEEEPK 15 0 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 EGEEPTVYS(1)DEEEPK 222.75 1.2237e-09 10300000.0 30948.0 9914.4 18077.0 16388.0 11188.0 13390.0 51197.0 30169.0 25349.0 14260.0 True False 29228.034054659885 10674.802600179435 16913.945500749436 14155.926129123152 9782.463418010972 15234.350957682129 53577.761944930935 30256.78679525319 30419.50831023803 13848.276748070455 2.1105899734948874 0.7708397798785185 1.221375468475248 1.022215715835948 0.7064029406672572 1.1000900137127028 3.8689118451070943 2.1848773927390646 2.1966277005892825 1.0 13.757418840900383 -7.1174880784229515 19.716770955644172 2.4220390209897227 1.1137820853179843 0.36377224150505816 0.7429834961224567 3.985598673994592 655.5934077087439 0.2710455324421911 0.20995128219036144 7.629778349556235e-08 7.1174880784229515 -1.3082569356717384 EGEEPTVYS(ph)DEEEPKDESAR ddPTM_A459_Selumetinib_30min_R1 4 EGEEPTVYSDEEEPKDESAR 20 1 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 EGEEPTVYS(1)DEEEPKDESAR;EGEEPT(0.011)VY(0.002)S(0.986)DEEEPKDESAR;EGEEPTVYS(1)DEEEPKDESAR;EGEEPT(0.031)VY(0.003)S(0.966)DEEEPKDESAR 186.7 6.7378e-16 634798000.0 7749.280000000001 14643.499999999998 10174.5 9525.8 8283.86 13047.1 11498.0 11537.449999999999 6523.0 12543.599999999999 True False 7929.82314652598 12929.032212421547 8792.858784527987 7862.297851412056 7534.58632563427 12915.85801981898 10630.696602907095 11231.439347080714 11069.054578929763 14153.69324501078 0.5602652967854356 0.9134741009721311 0.6212412995192966 0.555494436350282 0.5323406544995056 0.9125433055695098 0.7510899394866035 0.7935341788645752 0.7820612180380296 1.0 13.788890936566423 -6.767327324574132 24.99999184412678 0.8288943770716478 0.6465920646772247 0.42738391726399005 0.12101435086552488 170.10501305028782 722254.7169848201 0.04323098190055725 0.039124015709877495 1.708726974623503e-07 6.767327324574132 -0.18230231239442307 EGEEPTVYS(ph)DEEEPKDESAR ddPTM_A459_Selumetinib_30min_R2 5 EGEEPTVYSDEEEPKDESAR 20 1 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 EGEEPTVYS(1)DEEEPKDESAR;EGEEPTVY(0.002)S(0.997)DEEEPKDESAR;EGEEPT(0.008)VY(0.001)S(0.992)DEEEPKDESAR;EGEEPT(0.002)VY(0.002)S(0.996)DEEEPKDESAR;EGEEPT(0.003)VY(0.001)S(0.996)DEEEPKDESAR 159.1 6.353e-07 2038878400.0 896346.0 245692.0 527648.0 560390.0 264975.0 282255.1 1098373.0 589541.0 535733.0 443606.0 True False 846530.6776773364 264535.7863757044 493699.7021397056 484063.91527332994 231686.47159344453 321133.17796830967 1149449.520884811 591256.4667062334 642894.5696307044 430797.94215319405 1.9650295297285927 0.6140600046822742 1.1460122109036057 1.123644910776278 0.537807749116535 0.7454380500594708 2.66818712071763 1.3724681778911085 1.4923343561425082 1.0 18.716651832832227 EGEEPTVYS(ph)DEEEPKDESARK ddPTM_A459_Selumetinib_30min_R1 2 EGEEPTVYSDEEEPKDESARK 21 2 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 EGEEPT(0.052)VY(0.107)S(0.84)DEEEPKDESARK;EGEEPT(0.082)VY(0.074)S(0.785)DEEEPKDES(0.059)ARK 71.492 0.0060493000000000005 28486000.0 3981.8 6024.099999999999 6049.1 5735.2 4344.799999999999 6104.9 5365.3 5587.200000000001 3157.2 5561.0 True False 4074.5681927659243 5318.79557147189 5227.665445327852 4733.65498303748 3951.8136071367403 6043.490248805697 4960.591101372192 5439.0093062166525 5357.537807235483 6274.80851872708 0.6493533915187103 0.8476426899080693 0.8331195174682949 0.7543903481532467 0.6297903107867925 0.9631354057687949 0.7905565702231989 0.8668008418080017 0.853816939791228 1.0 12.615355719295566 -6.773335447880673 24.99999958158663 0.8800178998477847 0.7543356123980559 0.43882846513989815 0.08462547666288292 261.9374688455458 550467.2965075484 0.029766574769689243 0.02645716148083606 1.6852508393705235e-07 6.773335447880673 -0.12568228744972876 EGEEPTVYS(ph)DEEEPKDESARK ddPTM_A459_Selumetinib_30min_R2 2 EGEEPTVYSDEEEPKDESARK 21 2 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 EGEEPT(0.017)VY(0.052)S(0.927)DEEEPKDES(0.005)ARK;EGEEPT(0.363)VY(0.098)S(0.54)DEEEPKDESARK 88.28299999999999 0.0010106 35601400.0 206053.0 58725.9 136508.0 123798.0 58145.4 70097.1 182597.0 95160.8 81518.3 103401.1 True False 194601.39915551347 63229.98769646954 127725.2238986725 106936.49883653814 50840.65502552869 79752.33924688125 191088.12230909112 95437.70217328149 97824.2378116089 100415.64157467778 1.9379590281339885 0.6296826540658632 1.2719654218778749 1.06493866054733 0.5063021480345686 0.7942222745006364 1.9029716816277216 0.9504266534243646 0.9741932260509266 1.0 16.615624487396737 -4.745282697827427 24.841732253479282 1.0242167463526255 1.937961835249539 0.36905556445488363 0.36339677699403705 1024.9912179845833 1575884.3656677667 0.09295620521980882 2.3897663826010667 1.7977003466684873e-05 4.745282697827427 0.9137450888969134 EGEET(ph)EGSEEDDKENDKTEEMPNDSVLENK ddPTM_A459_Selumetinib_30min_R2 1 EGEETEGSEEDDKENDKTEEMPNDSVLENK 30 2 P49321-4;P49321;P49321-3 P49321-4 NASP Nuclear autoantigenic sperm protein 1 EGEET(0.822)EGS(0.168)EEDDKENDKT(0.01)EEMPNDSVLENK 65.155 0.00068142 17362000.0 64662.0 38510.0 43793.0 36645.0 33829.0 26848.0 67754.0 55501.0 41829.0 31359.0 True False 61068.3449024951 41463.59317083336 40975.40605821319 31653.88778384904 29579.09858490285 30546.06829812173 70904.69525200396 55662.4987213148 50195.968799911054 30453.584189533063 2.0052925305089166 1.361534094403392 1.3455035638234167 1.0394141979100286 0.9712846409411877 1.0030368874813906 2.3282873638359454 1.8277815305709098 1.6482778673113778 1.0 14.89432441353205 -7.2382051934068645 24.99685983947634 1.7700686390660876 1.267997020844068 0.18689157172305115 0.4112944558875262 1128.0507374539072 1213632.6307596003 0.15896838563287116 0.12305977719685024 5.77822975828818e-08 7.2382051934068645 -0.5020716182220195 EGES(ph)EMEGGSER ddPTM_A459_Selumetinib_30min_R2 1 EGESEMEGGSER 12 0 D6RD44;Q96EI5;Q96EI5-2;D6RCE9 D6RD44 TCEAL4 Transcription elongation factor A protein-like 4 1 EGES(1)EMEGGSER 145.52 0.00068097 1706200.0 5866.5 5152.0 5995.9 6413.5 5570.5 5413.7 5886.2 5536.3 3268.1 5254.0 True False 5540.463415460202 5547.141833708998 5610.130321842321 5539.970236095401 4870.683989098153 6159.3880343244045 6159.91996328403 5552.409716416198 3921.81131834348 5102.303368468596 1.0858749500665452 1.0871838526868927 1.099528961079032 1.0857782918850953 0.9546049376832798 1.2071779330857548 1.207282185796974 1.088216304567303 0.7686354642453515 1.0 12.316932964702765 -8.18005847746895 7.966415975806051 0.8853445860802587 1.1035119464067107 0.5146974766811514 0.08456657026265338 0.21983332723424256 19.24284744914489 0.05801941945993344 0.021728612382858652 6.60604492054473e-09 8.18005847746895 0.218167360326452 EGESEMEGGS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 EGESEMEGGSER 12 0 D6RD44;Q96EI5;Q96EI5-2;D6RCE9 D6RD44 TCEAL4 Transcription elongation factor A protein-like 4 1 EGESEMEGGS(1)ER 89.663 0.02547 1752200.0 4901.7 3906.1 5425.8 6141.6 4725.1 4242.8 3363.6 4946.7 3027.7 3560.5 True False 4629.28313705979 4205.685309908913 5076.709935164369 5305.103485149064 4131.490695070041 4827.207187696318 3520.0140648469546 4961.094078029729 3633.324601006257 3457.6991137100163 1.3388334221171418 1.2163248367196209 1.4682335762053045 1.5342871981295196 1.194867037067625 1.3960749703628368 1.0180220861005098 1.4347963529731802 1.050792588227204 1.0 11.755596616902881 -8.212454119326214 0.5303968696605406 0.995220120544312 1.3711167049541109 0.3843419765538131 0.14672485473155075 0.9350352182411856 0.6534272229237279 0.1532408818807794 0.08124415760213509 6.131205613324493e-09 8.212454119326214 0.3758965844097989 EGETQGVAFEHESPADFQNS(ph)QSPVQDQDK ddPTM_A459_Selumetinib_30min_R1 2 EGETQGVAFEHESPADFQNSQSPVQDQDK 29 0 E9PGM9;P78332;F8WCA5;P78332-3 E9PGM9 RBM6 RNA-binding protein 6 1 EGETQGVAFEHESPADFQNS(0.805)QS(0.195)PVQDQDK;EGETQGVAFEHESPADFQNS(0.5)QS(0.5)PVQDQDK 205.72 1.5747999999999996e-43 28071000.0 2195.52 2193.33 2047.79 2274.45 3672.4 2261.45 3594.58 2312.79 384.44 1182.2 True False 2246.671344261752 1936.533903948546 1769.7113657052978 1877.2600042142562 3340.2320684148826 2238.701866232314 3323.4379365870386 2251.4472961993147 652.3666016133315 1333.946885603157 1.6842284865382011 1.4517323926828791 1.3266730368391735 1.4072974152681013 2.5040217901213992 1.678254127202421 2.4914319846283193 1.6878088029579237 0.4890499079491892 1.0 10.381485507854398 -8.214027684999653 7.179381592879223 0.7466034975791739 1.7874636093147875 0.5109102391172912 0.40496251351252344 0.18658927153506186 24.49599760578214 0.29732576139028516 0.10911818834643479 6.109030803843839e-09 8.214027684999653 1.0408601117356135 EGETQGVAFEHESPADFQNS(ph)QSPVQDQDK ddPTM_A459_Selumetinib_30min_R2 4 EGETQGVAFEHESPADFQNSQSPVQDQDK 29 0 E9PGM9;P78332;F8WCA5;P78332-3 E9PGM9 RBM6 RNA-binding protein 6 1 EGETQGVAFEHESPADFQNS(0.5)QS(0.5)PVQDQDK;EGETQGVAFEHESPADFQNS(0.5)QS(0.5)PVQDQDK;EGETQGVAFEHESPADFQNS(0.831)QS(0.169)PVQDQDK;EGETQGVAFEHESPADFQNS(0.842)QS(0.158)PVQDQDK 154.17 1.4318e-16 45284600.0 84002.0 64387.8 126518.0 168008.1 188093.0 117736.6 88606.3 110937.5 106456.7 158159.0 True False 79333.50512664925 69326.13722059163 118377.96962238282 145125.10694986169 164463.075767245 133953.74794355762 92726.66852005261 111260.3097583082 127751.01464872473 153592.53872356733 0.5165192644509383 0.45136396466083145 0.7707273452614586 0.9448708131002044 1.070775163520425 0.872137078120994 0.6037185744220307 0.7243861627845881 0.8317527381889843 1.0 17.2287486084128 -5.350488914888977 4.108164489409789 0.8507443805848965 0.4828106421097416 0.579610199165593 0.1268826503486342 0.1731688697805528 5.244934432109807 0.038097321105367545 0.08666991521788829 4.46181012943354e-06 5.350488914888977 -0.3679337384751549 EGFGLSENPFAS(ph)LSPDEQKDEK ddPTM_A459_Selumetinib_30min_R2 2 EGFGLSENPFASLSPDEQKDEK 22 1 B4DT96;C9JYA1;O15504-2;O15504 B4DT96 NUPL2 Nucleoporin-like protein 2 1 EGFGLSENPFAS(0.5)LS(0.5)PDEQKDEK;EGFGLS(0.003)ENPFAS(0.637)LS(0.361)PDEQKDEK 66.282 0.0035454 5568200.0 18135.5 14655.099999999999 13040.5 17548.7 16183.800000000001 11561.5 15963.3 13268.7 12073.6 13401.0 True False 17127.6015121586 15779.099046426372 12201.488427422863 15158.53678680398 14150.6463589923 13153.991680152501 16705.625080678867 13307.309720248468 14488.657364570192 13014.07831002049 1.3160825610654892 1.2124638157645702 0.9375607043971792 1.1647798964858167 1.0873337336610833 1.010750924252875 1.2836579497002092 1.0225318615150947 1.1133064531672838 1.0 13.667785519593545 -5.023136337464242 8.463929492209651 1.0858594213943995 1.2911791410313276 0.41167562950769243 0.09260129297283957 0.1985403508802583 69.12134929733412 0.02242386256712254 0.06502569154707244 9.481207743373635e-06 5.023136337464242 0.20531971963692808 EGFGLSENPFASLS(ph)PDEQKDEK ddPTM_A459_Selumetinib_30min_R2 1 EGFGLSENPFASLSPDEQKDEK 22 1 B4DT96;C9JYA1;O15504-2;O15504 B4DT96 NUPL2 Nucleoporin-like protein 2 1 EGFGLSENPFAS(0.033)LS(0.967)PDEQKDEK 100.71 7.1551e-05 3089300.0 8023.2 7411.4 7257.7 8625.7 7226.1 6309.7 8086.1 8787.3 5442.8 7113.5 True False 7577.302663414348 7979.830548592944 6790.747483586285 7450.864779837543 6318.292715846356 7178.803901246226 8462.11967230318 8812.869588184174 6531.512084538384 6908.114771907374 1.0968698282530427 1.155138675611445 0.9830102289558974 1.0785670223860964 0.9146189553104133 1.0391842258382329 1.2249535440139678 1.2757271526557 0.9454840141190927 1.0 12.754076336765477 -7.198840898130403 24.969786729273665 1.1345186648432082 1.0424318113983555 0.06770168001076615 0.10899420499809104 448.7659142344934 179007.3192131658 0.04183429169687454 0.03240469668322486 6.326435751139536e-08 7.198840898130403 -0.09208685344485268 EGFLAESS(ph)PQTQR ddPTM_A459_Selumetinib_30min_R2 3 EGFLAESSPQTQR 13 0 K7ERF3;K7ELU8;D3DUE4;F6WF08;Q6ZW76-2;Q6ZW76 K7ERF3 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 1 EGFLAES(0.146)S(0.854)PQTQR;EGFLAES(0.146)S(0.853)PQT(0.001)QR;EGFLAES(0.045)S(0.954)PQTQR 183.28 0.00012007 6593500.0 54799.0 52178.0 57427.0 68593.0 67085.0 51038.0 58273.0 55587.0 47988.0 62183.0 True False 51753.49095777779 56179.88482128647 53732.20934179 59250.515070475 58657.18255249076 58068.02122316511 60982.8099657589 55748.748967076775 57586.94089674943 60387.615219163075 0.8570216056711346 0.9303213020980278 0.8897885625517948 0.981169977576342 0.971344576857488 0.961588249716775 1.0098562386415775 0.9231818273457133 0.9536217101428954 1.0 15.881965079861848 -5.758935381221808 24.998734970807437 0.9695107799643086 0.8961715556619018 0.6236457269541853 0.028103235227570255 44.653503033063416 445788.395985791 0.007609083614626129 0.012430379161296449 1.7420660565277957e-06 5.758935381221808 -0.0733392243024068 EGGSKS(ph)DSEDITR ddPTM_A459_Selumetinib_30min_R1 2 EGGSKSDSEDITR 13 1 E9PDC4;F5GYS8;H0YNY8;U3KPR8;O00470;O00470-2 E9PDC4 MEIS1 Homeobox protein Meis1 1 EGGS(0.05)KS(0.592)DS(0.357)EDIT(0.001)R;EGGS(0.031)KS(0.547)DS(0.418)EDIT(0.004)R 157.37 0.0017324000000000007 30108000.0 5328.5 6149.299999999999 5335.0 6551.8 5429.700000000001 5246.1 5372.1 5749.5 3177.5 4880.6 True False 5452.643682543884 5429.337097267985 4610.536303057327 5407.651122517955 4938.584593691396 5193.3289970776905 4966.878171897478 5597.0045829919545 5391.985424582143 5507.072551069843 0.9901165513943728 0.9858844325944541 0.8372027534232597 0.9819465918362427 0.8967712968902127 0.9430289775406713 0.901908977199252 1.016330279125275 0.9791019411092846 1.0 12.427069899575285 -7.768411635862156 24.999957451004917 0.998287093307819 0.9329004911432305 0.2974549422084274 0.04550769044507664 208.84616394507364 748831.526054794 0.02380830102399772 0.011833343538246955 1.7044660848421753e-08 7.768411635862156 -0.06538660216458847 EGGTASVATGPDSPS(ph)PVPLPPGKPALPGADGTPFGCPPGRK ddPTM_A459_Selumetinib_30min_R1 1 EGGTASVATGPDSPSPVPLPPGKPALPGADGTPFGCPPGRK 41 2 Q6SPF0;F8WDT5;E9PIW9 Q6SPF0 SAMD1 Atherin 1 EGGTAS(0.001)VAT(0.012)GPDS(0.469)PS(0.518)PVPLPPGKPALPGADGTPFGCPPGRK 58.277 2.3082e-05 18253000.0 1868.4 1414.5 2810.6 2905.2 2251.6 1867.4 1630.6 1778.0 1015.6 1002.6 True False 1911.930084726468 1248.8896824167898 2428.9359575207 2397.8613573581533 2047.9431775522678 1848.6156514635395 1507.6025291964086 1730.8416642420543 1723.3990235108201 1131.2934761510107 1.6900389907943338 1.1039484525853323 2.1470431932345675 2.119574989079204 1.8102669384428574 1.6340725819025028 1.3326361028136666 1.5299669809207075 1.5233881038316641 1.0 10.14375752138585 -7.07361901213939 3.467228173570448 1.3914942560843409 1.7749199557812216 0.3045681604689937 0.30181074595635066 0.38246358246249934 8.884537503905094 0.129341764272749 0.10054592421830488 8.440749036588675e-08 7.07361901213939 0.3834256996968808 EGHETPMDIDS(ph)DDSK ddPTM_A459_Selumetinib_30min_R2 2 EGHETPMDIDSDDSK 15 0 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 EGHETPMDIDS(0.817)DDS(0.183)K;EGHETPMDIDS(0.937)DDS(0.063)K 141.18 0.00025566 12740400.0 137661.0 110582.0 120190.0 123412.0 130369.0 98390.0 119040.0 122668.0 90780.0 102438.0 True False 130010.3527206456 119063.28382282791 112457.10625297752 106603.0727024253 113990.88070635252 111942.32940450661 124575.59587328498 123024.94357121926 108938.53660512852 99480.34877411243 1.3068948221709284 1.1968522958557573 1.1304454360964404 1.071599305954247 1.1458632997476597 1.1252707774345594 1.252263360637745 1.236675836858684 1.0950759416062419 1.0 16.60212394514408 -8.534133432238757 5.407002291138997 1.0000701879100562 1.177005216730741 0.4364419753903699 0.06591026992279533 0.14995213505816046 21.301565331672247 0.06871133793431522 0.01784203980674732 2.923254101945417e-09 8.534133432238757 0.1769350288206848 EGHLS(ph)PDIVAEQK ddPTM_A459_Selumetinib_30min_R1 4 EGHLSPDIVAEQK 13 0 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2;H3BRK3 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 1 EGHLS(1)PDIVAEQK;EGHLS(1)PDIVAEQK;EGHLS(1)PDIVAEQK;EGHLS(1)PDIVAEQK 218.45 1.6241e-08 90076000.0 19167.1 24129.9 21911.6 23475.9 22976.9 19466.8 23285.8 19634.4 9505.56 14720.400000000001 True False 19613.656137315727 21304.760090313826 18936.125071803355 19376.274762220946 20898.643451901182 19270.981666440202 21529.333358494856 19113.631930480446 16130.241061366187 16609.90672883835 1.1808408353830324 1.282653806437348 1.1400500545211487 1.1665492816151455 1.2582035403977718 1.160210107199558 1.296174247692513 1.1507368609900195 0.971121712162335 1.0 14.019756351572184 -8.157303433317542 3.9194718977242813 0.9852178965405204 1.2107296415454474 0.7514538841559624 0.05119809711055421 0.10677490886697845 2.7929969320656256 0.038132382310538296 0.012817056680161592 6.961399643691241e-09 8.157303433317542 0.225511745004927 EGHLS(ph)PDIVAEQK ddPTM_A459_Selumetinib_30min_R2 2 EGHLSPDIVAEQK 13 0 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2;H3BRK3 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 1 EGHLS(1)PDIVAEQK;EGHLS(1)PDIVAEQK 207.08 1.148e-05 63275000.0 261533.0 259316.0 256387.0 234206.0 238300.0 172425.0 163715.0 189404.0 153552.0 228758.0 True False 246998.04285955048 279204.70336763986 239891.33955305928 202306.73877211477 208362.6235709699 196174.9786316907 171328.07189511828 189955.13428248005 184266.69060135208 222153.16215533664 1.1118367186996938 1.2568117449186293 1.079846612245472 0.9106633315921715 0.9379232847708738 0.8830618332343109 0.7712159945547846 0.8550638327158148 0.8294578785806653 1.0 17.761195151428907 -5.694828258447071 2.161520866642215 0.8680726091923134 1.1883808395040838 0.7740538180896231 0.06714210268894118 0.13216679179439828 1.253402226811561 0.019879301555476302 0.040644410997801556 2.019164683568079e-06 5.694828258447071 0.32030823031177036 EGIDPTPYYWYTDQR ddPTM_A459_Selumetinib_30min_R2 1 EGIDPTPYYWYTDQR 15 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 151.26 0.0034618 3047700.0 10050.0 9328.0 8806.2 7837.8 9489.2 7416.7 7610.3 8131.8 7138.6 8647.0 False True 9491.461233337595 10043.427605752626 8239.6186794656 6770.278119040854 8297.08186147566 8438.28310290075 7964.19402952337 8155.462191708037 8566.51946914928 8397.338642395882 1.1302939702131085 1.196025078117737 0.9812178632246655 0.8062409302942195 0.9880608862891331 1.0048758853546944 0.9484188227582389 0.971196058538514 1.0201469577395925 1.0 13.035716453531885 -5.303029195839948 6.523265290005823 0.9593493862424104 1.1631636906312295 0.6451837896357039 0.05870973827445094 0.11434305967221607 13.853353254323887 0.015881176980383212 0.03421941009474738 4.97703625277219e-06 5.303029195839948 0.2038143043888191 EGIREETVSLR ddPTM_A459_Selumetinib_30min_R1 2 EGIREETVSLR 11 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 ; 150.09 0.0017460999999999998 25049300.0 3281.7 3796.6000000000004 3932.4 4790.7 4139.799999999999 3683.9 3451.3 3430.7 1939.42 2982.0 False True 3358.157224923385 3352.092307008545 3398.4016791270165 3954.0941775766587 3765.3558209410503 3646.8433107135784 3190.965662342429 3339.706691515871 3291.054090367618 3364.768747139751 0.9980350738154037 0.996232596923048 1.0099956147107747 1.175145894034432 1.1190533745125342 1.0838317830351958 0.9483462021141675 0.992551626127298 0.9780922071287083 1.0 11.716291639774312 -7.256284154796831 24.93917520256992 0.9791268103644828 1.0657868420718692 0.36629728716393484 0.05406249737941376 530.4949752438838 2566358.202867448 0.02407660997351467 0.01805219890153088 5.542629452584892e-08 7.256284154796831 0.08666003170738645 EGIREETVSLR ddPTM_A459_Selumetinib_30min_R2 3 EGIREETVSLR 11 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 ;; 136.96 0.0038684 11165400.0 43498.0 49038.0 56042.0 58975.0 61101.0 37609.0 39527.0 39031.0 39043.7 57882.0 False True 41080.555296290404 52799.05691797782 52436.31873391604 50942.50326245049 53424.94613012944 42789.29836948969 41365.083821264605 39144.57374807012 46853.530972126726 56210.79626450308 0.7308303391217503 0.93930455404917 0.9328513776459237 0.9062761363980268 0.9504392337503162 0.7612291803898709 0.7358921518673898 0.6963888852218552 0.8335325966857824 1.0 15.77855963137232 -6.7712993183836625 24.99935868853085 0.7820880753728324 0.8976409460479843 0.14457398639564067 0.09680356681052908 286.78793069513557 727131.3381900629 0.03273706473615922 0.02921697203310823 1.6931704549044424e-07 6.7712993183836625 0.11555287067515185 EGITGPPADSSKPIGPDDAIDALSS(ph)DFTCGSPTAAGK ddPTM_A459_Selumetinib_30min_R1 1 EGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 37 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 EGITGPPADSSKPIGPDDAIDALS(0.051)S(0.597)DFT(0.144)CGS(0.197)PT(0.01)AAGK 90.384 6.201699999999999e-10 30806000.0 2473.3 2536.1 2492.7 2891.1 2340.0 2325.0 2479.3 2280.8 1499.4 2530.4 True False 2530.9230777959624 2239.172232999098 2154.2050314209932 2386.223657668374 2128.347413160554 2301.6126109310967 2292.284404904118 2220.30577491748 2544.3722881568738 2855.2014881832392 0.8864253847830491 0.784243158413272 0.7544844174173189 0.8357461522572702 0.7454280974456967 0.806112150213122 0.8028450581828099 0.777635408256339 0.8911358090443747 1.0 11.4793768431209 -8.536352427924747 2.9952160415823563 0.9995997449732784 0.7970980138963804 0.7294138997794918 0.03851705351470572 0.11845909758385757 2.6983984479549115 0.035654367945416675 0.009512729992273334 2.9083560429769922e-09 8.536352427924747 -0.20250173107689806 EGITGPPADSSKPIGPDDAIDALSSDFT(ph)CGSPTAAGK ddPTM_A459_Selumetinib_30min_R1 1 EGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 37 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 EGITGPPADSSKPIGPDDAIDALS(0.007)S(0.029)DFT(0.602)CGS(0.347)PT(0.016)AAGK 107.29 1.4618e-18 26080000.0 8485.9 9440.6 9731.5 10856.0 9936.6 8769.1 9505.5 9104.4 5142.6 7672.4 True False 8683.604959312968 8335.290163184127 8410.01575130317 8960.203392358575 9037.836284449217 8680.890815705758 8788.492482078043 8862.921736740931 8726.61659935677 8657.2272755047 1.0030468974613735 0.9628129074037963 0.9714444918292713 1.034996899955617 1.043964308297812 1.002733385580394 1.0151624997699613 1.0237598545920397 1.008015190273265 1.0 13.07968931926775 -5.753630631351622 24.99999999998643 1.0196465199432212 0.9774725694645774 0.5554928768677276 0.016051897311541875 122.75439986260177 392998.08604222885 0.004429481660431237 0.007494722503479119 1.7634752493209379e-06 5.753630631351622 -0.04217395047864381 EGKPEIEGKPES(ph)EGEPGSETR ddPTM_A459_Selumetinib_30min_R1 2 EGKPEIEGKPESEGEPGSETR 21 2 D6RD44;Q96EI5;Q96EI5-2 D6RD44 TCEAL4 Transcription elongation factor A protein-like 4 1 EGKPEIEGKPES(0.977)EGEPGS(0.018)ET(0.005)R;EGKPEIEGKPES(0.731)EGEPGS(0.252)ET(0.016)R 88.41799999999998 0.00099936 39927000.0 4123.8 4579.1 5626.2 5692.2 4223.6 4813.4 4185.5 4423.8 2897.6 4360.1 True False 4219.876516482024 4042.9768432341634 4862.192942504431 4698.164125827512 3841.576125737143 4764.981566217524 3869.784365234616 4306.4664534724425 4917.015567669311 4919.761305970497 0.857740092260348 0.8217831296668213 0.9882985454200384 0.9549577375076997 0.7808460384196086 0.9685391769789449 0.7865796986000813 0.8753405268353618 0.999441896033075 1.0 12.264372606111499 -8.262983480188767 23.734410065070797 0.9997209871741974 0.8801086354685744 0.32754513835662113 0.06903132486670593 81.35165249454121 1250331.2905984104 0.05577229778040361 0.01736922309554868 5.457786211715735e-09 8.262983480188767 -0.11961235170562301 EGKPEIEGKPES(ph)EGEPGSETR ddPTM_A459_Selumetinib_30min_R2 4 EGKPEIEGKPESEGEPGSETR 21 2 D6RD44;Q96EI5;Q96EI5-2 D6RD44 TCEAL4 Transcription elongation factor A protein-like 4 1 EGKPEIEGKPES(0.997)EGEPGS(0.003)ETR;EGKPEIEGKPES(0.993)EGEPGS(0.007)ET(0.001)R;EGKPEIEGKPES(0.86)EGEPGS(0.137)ET(0.002)R;EGKPEIEGKPES(0.996)EGEPGS(0.003)ET(0.001)R 90.762 0.00080527 44747400.0 145659.8 141120.5 121794.5 129140.0 122971.4 87493.8 120738.1 113623.5 68705.9 120661.4 True False 137564.6114383789 151943.98857607308 113958.3744698249 111550.90922107441 107522.63335373551 99545.27676036218 126352.6608880063 113954.12557361685 82448.99980324191 117177.5918660329 1.1739839439238018 1.296698337595024 0.9725270220616201 0.9519815815007414 0.9176040541664677 0.8495248551802511 1.0783005425855063 0.97249076174819 0.7036242893394192 1.0 16.83833718076147 -5.3413443497846655 4.914475949226518 0.9295186716597118 1.2346539344454786 0.6102075656700596 0.09768889794548667 0.13165296892428194 5.618812161657808 0.025689723673282074 0.056297173158940964 4.556754700195377e-06 5.3413443497846655 0.30513526278576675 EGLEEGDQILR ddPTM_A459_Selumetinib_30min_R2 1 EGLEEGDQILR 11 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 141.1 0.014296 1577100.0 13758.0 10873.0 12491.0 16908.0 14979.0 9741.6 10001.0 10342.0 9171.0 11408.0 False True 12993.385437637671 11706.92413779463 11687.342659172496 14605.101232073119 13097.204106040968 11083.416974559834 10466.066316605551 10372.093507789736 11005.45625914998 11078.62139845637 1.1728341433752845 1.0567130797903974 1.0549455784093265 1.318313958640026 1.1822052252698028 1.0004328675862262 0.9447083657957507 0.9362260099650055 0.9933958263691018 1.0 13.435490746013022 -6.843139928405161 4.965013101653064 0.9651118268537675 1.154529678998283 0.6198585877110578 0.07144268452845609 0.15352683249955162 6.647086611095678 0.02783106185617623 0.02470283859892052 1.435026997380598e-07 6.843139928405161 0.18941785214451556 EGLELPEDEEEK ddPTM_A459_Selumetinib_30min_R1 3 EGLELPEDEEEK 12 0 P07900;P07900-2;Q58FG0;P08238;Q58FF7;Q58FF6 P07900;P08238;Q58FF6 HSP90AA1;HSP90AA5P;HSP90AB1;HSP90AB3P;HSP90AB4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4 0 ;; 213.35 3.9364e-05 24275300.0 11884.8 14785.699999999999 9928.099999999999 9580.099999999999 8939.3 10053.099999999999 11616.900000000001 11183.0 8250.3 13761.300000000001 False True 12161.692716204845 13054.58337031456 8579.918551149665 7907.115375749291 8130.7418933616 9951.974941484477 10740.62788018016 10886.390512496571 14000.156521929212 15527.696901413236 0.7832257928152863 0.8407288893645529 0.5525557721550305 0.5092265405457286 0.5236283233105606 0.6409176457185167 0.6917077238416867 0.7010949905588226 0.9016247941222374 1.0 13.922556241772408 -8.308159116848186 1.6521014459540824 1.0029712079415052 0.639515563834468 0.592376549878646 0.10056238847218398 0.28014356298760146 1.4899789189391264 0.10777450332108691 0.03207396974809046 4.918592952159619e-09 8.308159116848186 -0.36345564410703723 EGLELPEDEEEK ddPTM_A459_Selumetinib_30min_R2 3 EGLELPEDEEEK 12 0 P07900;P07900-2;Q58FG0;P08238;Q58FF7;Q58FF6 P07900;P08238;Q58FF6 HSP90AA1;HSP90AA5P;HSP90AB1;HSP90AB3P;HSP90AB4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4 0 ;; 204.69 0.0003913 49064200.0 210045.0 155390.0 167939.0 179715.0 181337.0 159758.0 221228.0 202884.0 158471.0 147061.0 False True 198371.53977675593 167307.91334239923 157133.9875781581 155237.50697433282 158555.82488665145 181763.2143612682 231515.54035496537 203474.3588507456 190169.62804969578 142814.96681963463 1.3890108592559867 1.1715012583638904 1.1002627461070476 1.0869834614070035 1.1102185465399885 1.2727182480168377 1.6210873797796934 1.424741141505985 1.331580521878122 1.0 17.123787654258933 -7.001853951882244 20.29797633336468 1.3893409960060663 1.1657803148144266 0.17651641818047625 0.16532859747391263 8.22663710058439 90080.03843832895 0.0578100087748406 0.04991120205477227 9.9574021675771e-08 7.001853951882244 -0.22356068119163974 EGLELPEDEEEKK ddPTM_A459_Selumetinib_30min_R2 1 EGLELPEDEEEKK 13 1 P07900;P07900-2;Q58FG0;P08238;Q58FF7;Q58FF6 P07900;P08238;Q58FF6 HSP90AA1;HSP90AA5P;HSP90AB1;HSP90AB3P;HSP90AB4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4 0 139.78 0.0012402 13727000.0 38433.0 30000.0 35925.0 37578.0 28871.0 27450.0 41805.0 37314.0 28456.0 32689.0 False True 36297.04771948895 32300.903534796154 33613.62461218254 32459.81157433429 25243.966869985223 31230.988333709833 43749.01533503596 37422.57756233476 34147.99512707139 31745.18363377804 1.1433875493751298 1.0175056445547477 1.058857463228419 1.0225113815311453 0.7952062007644118 0.983802415320695 1.3781308005566364 1.1788426866277681 1.0756905841532656 1.0 14.954250102938119 EGLITADAEGDFIDAR ddPTM_A459_Selumetinib_30min_R1 1 EGLITADAEGDFIDAR 16 0 C9J020;Q86UG4-3;Q86UG4-2;Q86UG4 C9J020 SLCO6A1 Solute carrier organic anion transporter family member 6A1 0 131.42 0.0097585 23820000.0 1823.2 1918.7 2280.1 2360.5 2402.2 1709.8 2119.0 1768.7 1078.5 1678.2 False True 1865.6770126703589 1694.0577120205692 1970.4749436927862 1948.2829870728087 2184.9214341428574 1692.6009643741884 1959.1621239833128 1721.788330452713 1830.1357294765828 1893.6133170522908 0.9852470912987562 0.8946164968134247 1.0405899271769712 1.0288705563740015 1.1538371717537528 0.8938472016076598 1.0346157298011924 0.9092607846320754 0.9664780623350702 1.0 10.886926041800855 -9.941095253463311 11.467572928332158 0.9999984273531293 0.9905213803981703 0.001529573879989754 0.07638501506570963 0.0 0.0 0.07486743709556143 0.018158020650840333 1.1452617245537487e-10 9.941095253463311 -0.00947704695495899 EGLRPGDTTST(ph)FCGTPNYIAPEILR ddPTM_A459_Selumetinib_30min_R1 1 EGLRPGDTTSTFCGTPNYIAPEILR 25 1 P41743 P41743 PRKCI Protein kinase C iota type 1 EGLRPGDT(0.052)T(0.171)S(0.171)T(0.6)FCGT(0.006)PNYIAPEILR 59.565 0.011003 14525000.0 2171.1 2941.3 1303.2 1755.8 1477.7 1730.4 1649.4 1671.9 1310.5 1529.9 True False 2221.682405774799 2596.9312286267277 1126.2325979651946 1449.1824904479713 1344.0422959091252 1712.9937470774926 1524.9844300604411 1627.5557809034274 2223.8227848670026 1726.2775674879633 1.2869786687941132 1.5043532265820485 0.6524052789517856 0.8394840538632418 0.7785783243797476 0.992304933655715 0.8833946862204558 0.9428123330547628 1.2882185499884904 1.0 10.75344873819573 -5.250104345838878 24.99876516094102 0.9131488837755488 1.3956659929296056 0.5688639208724435 0.1647422835029089 516.544563137607 1139204.0919678935 0.04255879485200592 0.1104849143167051 5.622062303844402e-06 5.250104345838878 0.48251710915405677 EGLYLS(ph)DTLPR ddPTM_A459_Selumetinib_30min_R2 1 EGLYLSDTLPR 11 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PRT1 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 EGLYLS(0.685)DT(0.315)LPR 89.35600000000002 0.029351 1755000.0 26783.0 24941.0 28769.0 31513.0 32491.0 26022.0 23635.0 24192.0 21991.0 30642.0 True False 25294.50808084386 26853.89450204503 26918.033861318836 27220.87503704283 28409.19010677461 29606.294295803156 24734.074331864012 24262.394714798793 26389.814479878674 29757.285842522768 0.8500273921050402 0.902430908657374 0.9045863256404024 0.914763368577942 0.954696952441081 0.9949258965512289 0.8311938952617562 0.8153430001377394 0.8868353995567694 1.0 14.860955324002704 -10.483328216866717 24.22144129051914 0.9999999983673462 0.8965396965895932 0.2712208687685058 0.05158896462011121 0.0 0.0 0.05512333217647895 0.013369371823507729 3.2860319604429546e-11 10.483328216866717 -0.103460301777753 EGLYLSDT(ph)LPR ddPTM_A459_Selumetinib_30min_R2 2 EGLYLSDTLPR 11 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PRT1 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 EGLYLS(0.004)DT(0.996)LPR;EGLYLS(0.001)DT(0.999)LPR 108.68 0.022986000000000003 4493200.0 26485.0 18042.300000000003 25789.0 24499.0 21542.0 30737.0 17990.300000000003 18102.4 14663.3 21096.0 True False 25013.06972785534 19426.08639486176 24129.76381694015 21162.193936867738 18835.701372076528 34970.742747294666 18826.884597103166 18155.074986986347 17596.36972683392 20486.90366600942 1.220929728358876 0.9482197364500863 1.1778140909099277 1.0329620464794158 0.9194020569993472 1.7069803869540285 0.9189716954807352 0.8861795458680319 0.8589082085658805 1.0 14.322414335433693 -7.4749315047894775 24.99997140427614 0.9040391493960225 1.1551363940515464 0.2576922735192346 0.208386860818001 561.9602454805625 293009.8281544606 0.08727021071727953 0.05883596891502073 3.350182727502527e-08 7.4749315047894775 0.25109724465552397 EGMNIVEAMER ddPTM_A459_Selumetinib_30min_R1 2 EGMNIVEAMER 11 0 P62937;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 ; 210.08 0.0026128 43519000.0 2635.6000000000004 2715.8 2795.4 2646.8 3082.6 2380.25 2770.0 2529.19 1214.06 2398.9 False True 2697.004352015136 2397.832873458834 2415.8000340330764 2184.5860665894124 2803.7793742772337 2356.306846094082 2561.0566698602056 2462.1076652330507 2060.1711485659157 2706.8221822647706 0.9963729312128586 0.8858479471498167 0.8924856792815998 0.8070667075594864 1.0358195645978268 0.8705067002674642 0.9461488407477863 0.9095934270691658 0.7611032457411707 1.0 11.402384401180285 -10.944022381824094 5.412536298477316 1.000072257572113 0.9018324705169947 0.13085666919149885 0.07682711052497987 6.444746075506191e-05 6.892473523256234e-06 0.0715652363503247 0.01734436663647131 1.1375686585123352e-11 10.944022381824094 -0.09823978705511838 EGMNIVEAMER ddPTM_A459_Selumetinib_30min_R2 3 EGMNIVEAMER 11 0 P62937;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 ;; 201.84 0.0027483 26680100.0 87536.5 79807.6 93249.9 106617.5 111103.4 86607.7 93958.6 98341.4 77164.5 80498.7 False True 82671.57176637379 85928.58629812014 87250.30295681447 92096.0125745537 97145.59761500174 98537.12452857698 98327.86107543383 98627.55719270479 92599.55615627296 78174.49337025941 1.0575261597771382 1.0991895513941465 1.1160968136188503 1.1780826277742218 1.2426763951624107 1.2604766629170672 1.2577997865585342 1.2616334681642658 1.184523904973606 1.0 16.25441034397693 -5.741109482802678 1.9694300416437536 1.219982668564884 1.0788885265279744 0.2923711834634317 0.07483589038062989 0.3407437456780042 2.6926334004837966 0.021637917136539567 0.043909050620215384 1.8150580408151619e-06 5.741109482802678 -0.14109414203690962 EGMNPSYDEY(ph)ADSDEDQHDAYLER ddPTM_A459_Selumetinib_30min_R2 1 EGMNPSYDEYADSDEDQHDAYLER 24 0 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 1 EGMNPS(0.038)Y(0.08)DEY(0.557)ADS(0.324)DEDQHDAYLER 81.808 0.00085611 65883000.0 20986.0 18090.0 24848.0 23269.0 21829.0 16849.0 18020.0 17356.0 17892.0 22327.0 True False 19819.682133614202 19477.4448314821 23249.306732456836 20099.72205873608 19086.64586626399 19169.796810006424 18857.965705952603 17406.503086559525 21470.899944249428 21682.361497487305 0.9140924126696733 0.8983082785396449 1.0722681998983883 0.9270079765557533 0.8802844592585487 0.8841194171690177 0.869737630199459 0.80279553906417 0.9902473006336333 1.0 14.404234273472682 -5.999205052064843 24.999089782191973 0.8929771777521472 0.9626325848736585 0.10564467737295202 0.06952802573375529 49.43275584593413 1554382.0562848132 0.0193293099887146 0.028394344955293895 1.0018321115344403e-06 5.999205052064843 0.0696554071215113 EGMNPSYDEYADS(ph)DEDQHDAYLER ddPTM_A459_Selumetinib_30min_R1 13 EGMNPSYDEYADSDEDQHDAYLER 24 0 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 1 EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPS(0.002)Y(0.006)DEY(0.005)ADS(0.987)DEDQHDAYLER;EGMNPSY(0.002)DEY(0.029)ADS(0.969)DEDQHDAYLER;EGMNPSYDEY(0.001)ADS(0.999)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER 158.8 7.5009e-13 1764648700.0 32978.35 38815.54000000001 39981.4 42746.89 38856.19000000001 34113.880000000005 38759.740000000005 33675.48 20068.100000000002 30610.48 True False 33746.68139030141 34270.99853194501 34552.145482109896 35281.94812000539 35341.65447511755 33770.72534012478 35836.06160615432 32782.29687702476 34054.0999839676 34539.63327932473 0.9770422609119601 0.9922224203943556 1.0003622563877266 1.021491682748265 1.023220315899327 0.977738387290284 1.0375345133616583 0.9491211621128618 0.9859427200216464 1.0 15.075965144845116 -9.8512656487673 12.659209473986204 0.9999999999999184 0.9969328788232179 0.001176690566204397 0.024793981136390728 0.0 0.0 0.024121498329425974 0.005850322674140191 1.4084270298014812e-10 9.8512656487673 -0.0030671211767004936 EGMNPSYDEYADS(ph)DEDQHDAYLER ddPTM_A459_Selumetinib_30min_R2 18 EGMNPSYDEYADSDEDQHDAYLER 24 0 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 1 EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSY(0.001)DEY(0.005)ADS(0.994)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEY(0.001)ADS(0.999)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPSYDEY(0.005)ADS(0.994)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPS(0.103)Y(0.067)DEY(0.188)ADS(0.642)DEDQHDAYLER;EGMNPSYDEY(0.004)ADS(0.996)DEDQHDAYLER;EGMNPSYDEY(0.001)ADS(0.999)DEDQHDAYLER;EGMNPSYDEY(0.001)ADS(0.999)DEDQHDAYLER;EGMNPSYDEYADS(1)DEDQHDAYLER;EGMNPS(0.003)Y(0.014)DEY(0.398)ADS(0.584)DEDQHDAYLER;EGMNPS(0.001)Y(0.001)DEY(0.012)ADS(0.985)DEDQHDAY(0.001)LER 154.27 1.2947e-10 3835538000.0 1128856.9 1137349.2 1254149.4 1297548.9 1469953.4000000001 1022974.3 1050641.5 1050894.6 970773.0 1213828.4 True False 1066119.5526702155 1224580.2264859215 1173458.7930186233 1120820.5014232968 1285284.7123418692 1163879.7241888868 1099498.4115566358 1053952.5293010334 1164954.7256639197 1178782.020187067 0.9044246810797364 1.0388521418842023 0.9954841293154445 0.9508293155382773 1.090349776575232 0.9873578865787117 0.9327410774234159 0.8941029904186832 0.9882698460899895 1.0 20.168865529821716 -7.162855356221591 5.64467224586535 0.94520650228854 0.9996215295922214 0.11169449156929856 0.053768970848056596 0.39729001025571137 18.48240634679947 0.020366793599787325 0.015681484323108934 6.872973094350535e-08 7.162855356221591 0.05441502730368142 EGNTTEDDFPS(ph)SPGNGNK ddPTM_A459_Selumetinib_30min_R2 1 EGNTTEDDFPSSPGNGNK 18 0 Q15007 Q15007 WTAP Pre-mRNA-splicing regulator WTAP 1 EGNTTEDDFPS(0.765)S(0.235)PGNGNK 303.45 3.032899999999997e-197 0.0 28723.0 23549.0 26593.0 26834.0 27265.0 20824.0 22410.0 21032.0 19847.0 27952.0 True False 27126.690647279167 25355.13257803051 24882.03533226918 23179.162908768063 23839.7269478074 23692.31697854912 23452.109404572562 21093.199637964968 23816.95457151344 27144.953131982147 0.9993272235684407 0.9340643343442404 0.9166357816603927 0.8539032208332828 0.878237911551944 0.8728074372924544 0.8639583678979103 0.777057876482866 0.8773989940491862 1.0 14.728396372485893 -4.844707715396753 0.9751750597580129 0.8636304721441304 1.0589798922619673 0.3381333045002146 0.0524060871108004 1.8354775007266901 1.4883761908776612 0.017022749874805673 0.37105405705958067 1.4298559423536743e-05 4.844707715396753 0.19534942011783696 EGNTTEDDFPSS(ph)PGNGNK ddPTM_A459_Selumetinib_30min_R1 4 EGNTTEDDFPSSPGNGNK 18 0 Q15007 Q15007 WTAP Pre-mRNA-splicing regulator WTAP 1 EGNTTEDDFPSS(1)PGNGNK;EGNTTEDDFPS(0.001)S(0.999)PGNGNK;EGNTTEDDFPS(0.082)S(0.918)PGNGNK;EGNTTEDDFPS(0.08)S(0.92)PGNGNK 265.29 2.6401e-43 65863000.0 16765.5 17352.8 18694.7 18994.5 17178.7 14666.5 16548.0 16355.5 9072.7 13540.900000000001 True False 17156.10353001585 15321.126108902145 16156.062422636529 15677.467145924371 15624.889618145817 14518.968326116526 15299.771037128772 15921.69900984866 15395.709256209744 15279.00641453543 1.12285465851331 1.0027567037557261 1.0574026860324324 1.026078968787517 1.0226378073433713 0.950256052795694 1.0013590296404082 1.0420637689308 1.0076381171987263 1.0 13.89926310830077 EGNTTEDDFPSS(ph)PGNGNK ddPTM_A459_Selumetinib_30min_R2 4 EGNTTEDDFPSSPGNGNK 18 0 Q15007 Q15007 WTAP Pre-mRNA-splicing regulator WTAP 1 EGNTTEDDFPS(0.002)S(0.998)PGNGNK;EGNTTEDDFPS(0.002)S(0.998)PGNGNK;EGNTTEDDFPS(0.032)S(0.968)PGNGNK;EGNTTEDDFPS(0.223)S(0.777)PGNGNK 183.88 5.5276e-10 55377400.0 244208.0 249315.0 245377.0 273885.0 256483.0 194489.0 221065.0 230471.0 176335.0 240806.0 True False 230635.89700208046 268436.6588259231 229589.71096627787 236581.39052202177 224261.3125528876 221278.0943546409 231344.9605319872 231141.63245347186 211606.92721155894 233853.30509087382 0.9862417677289482 1.1478848191673428 0.9817680826749952 1.011665798052706 0.9589828652015038 0.946226072232136 0.9892738545734391 0.9884043860900396 0.9048703721734013 1.0 17.83524429320657 -5.42673378644641 9.710898546348508 0.9720795522281334 1.067076902867701 0.4022178080915084 0.04618564322242567 0.373508870979702 35.468860346132836 0.011357298859856474 0.02366813849912195 3.74339980640251e-06 5.42673378644641 0.0949973506395676 EGPEPPEEVPPPT(ph)TPPVPK ddPTM_A459_Selumetinib_30min_R1 4 EGPEPPEEVPPPTTPPVPK 19 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 EGPEPPEEVPPPT(0.576)T(0.424)PPVPK;EGPEPPEEVPPPT(0.949)T(0.051)PPVPK;EGPEPPEEVPPPT(0.57)T(0.43)PPVPK;EGPEPPEEVPPPT(0.949)T(0.051)PPVPK 166.62 1.5038e-08 56530600.0 23549.899999999998 29298.8 25018.1 25785.8 24088.4 24079.699999999997 26529.2 23520.4 13776.89 19457.1 True False 24098.56684987148 25868.48287535741 21620.779434586424 21282.794089414114 21909.608473152435 23837.480080618276 24528.08108521855 22896.56258697347 23378.37610576602 21954.60831320351 1.0976541465045675 1.1782712087739728 0.9847945873661376 0.9693998538163231 0.9979503237129487 1.0857620295727346 1.1172178858899229 1.0429046266884874 1.0648505212323125 1.0 14.42223617547418 EGPEPPEEVPPPT(ph)TPPVPK ddPTM_A459_Selumetinib_30min_R2 4 EGPEPPEEVPPPTTPPVPK 19 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 EGPEPPEEVPPPT(0.856)T(0.144)PPVPK;EGPEPPEEVPPPT(0.996)T(0.004)PPVPK;EGPEPPEEVPPPT(0.988)T(0.012)PPVPK;EGPEPPEEVPPPT(0.981)T(0.019)PPVPK 131.79 0.0006082999999999999 46690000.0 300643.0 281170.0 289633.0 312507.0 297749.0 238279.0 258791.0 243130.0 226470.0 293168.0 True False 283934.4656292854 302734.8348959552 270998.32810856734 269943.0074953564 260343.10871016688 271099.76936859876 270825.2942846379 243837.46804766197 271770.3281005016 284703.47809805925 0.9972989003369007 1.0633338128439918 0.9518616699695832 0.9481549340341427 0.9144359965300388 0.9522179749248619 0.9512539014060049 0.8564611492511448 0.9545732630877691 1.0 18.119100592399924 -5.390107129952904 4.910370565356765 0.9346684128417654 1.0295678953364733 0.4702546730814334 0.03769858105215159 0.16714460161884187 5.8862846894151675 0.009659468915955092 0.020829941600328004 4.072797993282282e-06 5.390107129952904 0.09489948249470792 EGPET(ph)PPRPR ddPTM_A459_Selumetinib_30min_R2 1 EGPETPPRPR 10 1 A0A5E8;Q99501 A0A5E8 GAS2L1 GAS2-like protein 1 1 EGPET(1)PPRPR 87.667 0.04614 4234300.0 21454.0 21090.0 19057.0 23612.0 24603.0 13163.0 19967.0 15418.0 15729.0 20231.0 True False 20261.672567166646 22707.53518496171 17830.893367692774 20396.004867028085 21512.151186389343 14976.083768182969 20895.5050638599 15462.8638274127 18875.239504979836 19646.878463549332 1.031292202715965 1.1557833590252409 0.9075687723510003 1.0381295382301368 1.0949399023514415 0.762262758227367 1.0635534343344737 0.7870392162348235 0.9607246026384746 1.0 14.262012491885997 -6.729123751113403 24.999800872798826 0.9107080265076707 1.0435901832517216 0.28890576886107944 0.10250536224785972 243.61987603945505 188466.97092564887 0.03201900924302433 0.03201665476770371 1.8658479464288514e-07 6.729123751113403 0.1328821567440509 EGPGEEHFEDMAS(ph)DEDMKPK ddPTM_A459_Selumetinib_30min_R1 1 EGPGEEHFEDMASDEDMKPK 20 1 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 EGPGEEHFEDMAS(1)DEDMKPK 89.721 0.00098666 4019300.0 701.35 764.04 824.77 574.41 775.18 700.31 512.87 598.01 590.46 508.8 True False 717.6900904104631 674.5858416074404 712.7707641373179 474.1000765111173 705.0651058691449 693.2655172306049 474.18380298599396 582.1488321897592 1001.9674945078758 574.1094361316917 1.250092831161612 1.175012635487672 1.2415242099832329 0.8258008781488939 1.2281022771892116 1.2075494210681823 0.8259467152830835 1.0140032466845283 1.7452552273989104 1.0 9.165181957887862 -11.009687642986437 0.0031751300770551105 1.3933336760306409e-05 2.246337075735782 0.0 0.2517997715535886 1613692.1073998834 824.591543135071 298283.8614885007 285192.88413363125 9.779403307351809e-12 11.009687642986437 2.2463231423990218 EGPGEEHFEDMAS(ph)DEDMKPK ddPTM_A459_Selumetinib_30min_R2 2 EGPGEEHFEDMASDEDMKPK 20 1 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 EGPGEEHFEDMAS(1)DEDMKPK;EGPGEEHFEDMAS(1)DEDMKPK 96.579 0.00054312 14011900.0 59518.0 67808.0 51853.0 56886.0 49592.0 40955.0 44958.0 46044.0 35006.6 48784.0 True False 56210.22782943154 73008.6555629152 48516.83443327769 49138.028666176455 43361.8096018949 46596.179497525896 47048.63608258697 46177.98041700546 42008.898166127976 47375.47916394592 1.1864835738106712 1.541064214047609 1.024091688136431 1.0372038348389283 0.9152795996392679 0.983550569193755 0.9931010073749779 0.9747232372511434 0.8867223911499335 1.0 15.53185291457888 -5.377668113735416 5.9342351096809685 0.9730736167894558 1.3609769793936823 0.7513362930544074 0.0893506053279873 0.09319925724924479 4.155140990868133 0.021860785038110304 0.046323443749695756 4.191137279562925e-06 5.377668113735416 0.38790336260422653 EGPPAPPPVKPPPS(ph)PVNIR ddPTM_A459_Selumetinib_30min_R1 4 EGPPAPPPVKPPPSPVNIR 19 1 Q8TF74-2;Q8TF74 Q8TF74-2 WIPF2 WAS/WASL-interacting protein family member 2 1 EGPPAPPPVKPPPS(1)PVNIR;EGPPAPPPVKPPPS(1)PVNIR;EGPPAPPPVKPPPS(1)PVNIR;EGPPAPPPVKPPPS(1)PVNIR 144.58 3.2563e-05 505993000.0 16178.800000000001 19392.899999999998 21454.1 23952.0 20150.1 17847.600000000002 20095.0 18648.2 11304.8 14991.699999999999 True False 16555.734561535333 17122.370252485387 18540.75105893576 19769.232834724804 18327.527012789098 17668.069348324225 18579.217971422677 18153.589158109502 19183.419930075932 16916.030726524143 0.9787009038459673 1.0121978689502915 1.0960461918447615 1.168668534263589 1.0834413408845223 1.044457156289087 1.0983201834867016 1.073158913671449 1.1340378981457244 1.0 14.046103465563428 -5.1543915014591075 3.7147697843849854 1.091531821333645 0.9858782792916051 0.4204609786815683 0.04354891920046972 0.21289192467224866 5.2229594764692235 0.011212303998106314 0.03531179531257721 7.008232456518869e-06 5.1543915014591075 -0.1056535420420398 EGPPAPPPVKPPPS(ph)PVNIR ddPTM_A459_Selumetinib_30min_R2 1 EGPPAPPPVKPPPSPVNIR 19 1 Q8TF74-2;Q8TF74 Q8TF74-2 WIPF2 WAS/WASL-interacting protein family member 2 1 EGPPAPPPVKPPPS(1)PVNIR 65.387 0.013238 6535800.0 26737.0 27822.0 33193.0 29092.0 32610.0 28281.0 29118.0 18390.0 17695.0 29857.0 True False 25251.06457669126 29955.857938169953 31057.398517805846 25129.619413500786 28513.24026290113 32176.451040642874 30472.044696222394 18443.511855371602 21234.49443960952 28994.950832197737 0.8708779926141816 1.0331404978588605 1.0711312703216536 0.8666894991108364 0.9833863981324057 1.1097260080507607 1.0509431408445227 0.6360939172516484 0.7323514553447512 1.0 14.8235140713909 -7.749767859643784 24.99964572162785 0.7631669995903114 1.0008368706376065 0.4091998408851605 0.1134587044138379 178.9885923447873 383384.00230369996 0.05309229833923803 0.030328405126397565 1.779230195233945e-08 7.749767859643784 0.2376698710472951 EGPS(ph)GSGDSQLSASSR ddPTM_A459_Selumetinib_30min_R2 1 EGPSGSGDSQLSASSR 16 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EGPS(0.566)GS(0.387)GDS(0.044)QLSAS(0.003)SR 152.25 0.00017757 4603000.0 8118.3 4256.5 7382.9 6297.7 10202.0 6071.0 7269.9 8425.9 5752.5 6903.6 True False 7667.117386129812 4582.959863195328 6907.892251893739 5439.94239586154 8920.333552962808 6907.225142949081 7607.9647550335585 8450.41797401716 6903.160738279383 6704.275130293071 1.1436161609009998 0.683587677135647 1.0303712359119377 0.8114139545498841 1.330544075176232 1.0302717309048053 1.134793039840682 1.260452145800848 1.0296654901717344 1.0 12.710865640287166 -6.246354484757291 24.986815943683542 1.1391348268648216 0.9086375708648736 0.32646116380331014 0.14990043499663472 857.8898047061377 1421019.7905785432 0.041119675782493 0.05287782077249411 5.670815467345503e-07 6.246354484757291 -0.23049725599994797 EGPSCPS(ph)PGPFCR ddPTM_A459_Selumetinib_30min_R1 3 EGPSCPSPGPFCR 13 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 EGPS(0.01)CPS(0.99)PGPFCR;EGPS(0.043)CPS(0.957)PGPFCR;EGPS(0.044)CPS(0.956)PGPFCR 115.24 0.0040425 35615800.0 6359.6 7143.799999999999 5599.299999999999 6175.700000000001 8083.6 5393.299999999999 7532.4 6878.0 3315.12 5093.3 True False 6507.766306372538 6307.400574937482 4838.945814753305 5097.229927246577 7352.439807275498 5339.048298724591 6964.225003629971 6695.5730971073435 5625.516513215035 5747.074667943288 1.1323615373700164 1.0974975860535876 0.8419841561733222 0.8869259965732669 1.2793360504408975 0.9290027722286899 1.2117860661313222 1.1650402133201265 0.9788486905509869 1.0 12.488612077940456 -6.231070634502352 24.99925885175995 1.0998936121327882 0.9868421374317784 0.13401454137187574 0.12930023564313475 1407.8035992199648 1158890.5396929507 0.03858083149796393 0.04980245662268957 5.87393809884436e-07 6.231070634502352 -0.11305147470100985 EGPSCPS(ph)PGPFCR ddPTM_A459_Selumetinib_30min_R2 2 EGPSCPSPGPFCR 13 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 EGPS(0.04)CPS(0.96)PGPFCR;EGPS(0.06)CPS(0.94)PGPFCR 141.59 0.00082077 64149000.0 70549.0 71520.0 76823.0 73713.0 87630.0 60573.0 70752.0 59522.0 60847.0 80605.0 True False 66628.16901002337 77005.35402695405 71880.29181855799 63673.162237982404 76621.13597786042 68916.380923053 74042.10819242823 59695.19916560246 73018.10020722916 78277.72421305884 0.8511766237438465 0.9837454371739065 0.9182726317248555 0.8134263339679464 0.9788370414207564 0.8804085915358777 0.9458898931565515 0.7626077503623143 0.932808164024878 1.0 16.256314192306945 -5.543192715231242 24.980968782568777 0.8938990698385586 0.9258481120301478 0.0 0.07450639296902288 911.6341854973839 1121070.2490998262 0.019265833705011216 0.03337336660900699 2.8629072923035634e-06 5.543192715231242 0.03194904219158923 EGPSGSGDSQLS(ph)ASSR ddPTM_A459_Selumetinib_30min_R1 1 EGPSGSGDSQLSASSR 16 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EGPSGSGDSQLS(0.992)AS(0.007)S(0.002)R 171.78 1.3529e-08 0.0 574.86 929.82 728.39 730.41 642.08 636.02 707.34 602.94 414.91 442.43 True False 588.2531195171581 820.9562421384097 629.4786387598737 602.8576049937939 584.0039773684314 629.6222162599556 653.9847743172992 586.9480725748623 704.0719661725816 499.2202001331453 1.1783439839979775 1.644477210496401 1.2609238139642338 1.2075985804120262 1.1698324250754952 1.2612114175108124 1.310012644005345 1.1757298130530764 1.4103435036979695 1.0 8.96353250146347 -14.522878692440157 0.1604087234919174 7.063148726542983e-11 1.3625037200143533 0.26116361627580076 0.139962687571446 186.8071703227675 1.7134118196869672 60.39732807031436 0.5934584013403168 3.0000003650070573e-15 14.522878692440157 1.3625037199437218 EGPSGSGDSQLS(ph)ASSR ddPTM_A459_Selumetinib_30min_R2 2 EGPSGSGDSQLSASSR 16 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 EGPSGSGDSQLS(0.998)AS(0.001)SR;EGPSGSGDSQLS(0.999)AS(0.001)SR 161.75 2.3855e-05 0.0 12300.0 11206.5 12809.099999999999 15095.1 13341.6 15002.5 12461.7 18043.6 12757.4 17074.9 True False 11616.415240801241 12066.002515423115 11984.976451493585 13039.121339500067 11665.508932582698 17068.95819586453 13041.193742390102 18096.103888721227 15309.236471538543 16581.903271081912 0.7005477628771206 0.7276608914047688 0.7227744762204011 0.786346484256708 0.7035084418160138 1.029372679168381 0.786471464052824 1.0913164546243623 0.9232496548352901 1.0 14.01732198844352 -6.788588374903583 1.1437585305674869 0.9822414834919926 0.7166371328466865 0.6172050302709571 0.0877661212639007 0.3037726244867577 0.8408274831138978 0.0435271792659029 0.038253397613529895 1.6270901841738442e-07 6.788588374903583 -0.2656043506453061 EGPTDHLESACPLNLPLQNNHTAADMYLS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 EGPTDHLESACPLNLPLQNNHTAADMYLSPVR 32 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 EGPTDHLESACPLNLPLQNNHT(0.015)AADMY(0.005)LS(0.98)PVR 66.88 0.00011377 4308500.0 553.1 710.47 696.67 460.31 504.15 471.9 609.2 603.88 238.13 555.67 True False 565.9861538547473 627.2878421114577 602.0660405343862 379.92549958885166 458.5497215149115 467.1531144509178 563.2475535302664 587.863140721312 404.0892176729336 626.9956571841535 0.9026954929745434 1.0004660078964764 0.9602395704593448 0.605945982616694 0.7313443343041081 0.7450659491788335 0.8983276791099626 0.9375872607498014 0.64448487488367 1.0 9.29231164016953 -5.627500742335426 24.026032360953923 0.7910228846625852 0.9591677150926651 0.27215125523758954 0.11956774738536873 9.496221545436937 2150.7733773257855 0.03258275446778807 0.05643497656647656 2.357758165864207e-06 5.627500742335426 0.16814483043007988 EGPVAS(ph)PPFMDLEQAVLPAVIPK ddPTM_A459_Selumetinib_30min_R1 2 EGPVASPPFMDLEQAVLPAVIPK 23 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 EGPVAS(1)PPFMDLEQAVLPAVIPK;EGPVAS(1)PPFMDLEQAVLPAVIPK 159.1 9.2548e-10 11698500.0 5284.7 6355.2 6996.3 6945.2 5849.1 5333.5 6041.0 6145.5 3152.3999999999996 4738.4 True False 5407.823227763849 5611.130229547676 6046.24088792502 5732.351197550548 5320.049937742476 5279.849832430539 5585.322506362998 5982.501376602675 5349.392557813611 5346.619795924544 1.0114471262546025 1.0494724599315544 1.1308529722898497 1.0721449095594993 0.995030531588889 0.9875117427379257 1.0446455367221745 1.1189315127967079 1.0005186009095282 1.0 12.384411373398505 EGPVLAT(ph)SSGAGVFK ddPTM_A459_Selumetinib_30min_R2 2 EGPVLATSSGAGVFK 15 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 EGPVLAT(0.619)S(0.262)S(0.119)GAGVFK;EGPVLAT(0.8)S(0.185)S(0.015)GAGVFK 209.56 3.2147000000000007e-06 15823400.0 106285.0 97310.0 95446.0 122091.0 113770.0 71930.0 100743.0 90382.0 81801.0 78382.0 True False 100378.10519256575 104773.36409903388 89305.1082737475 105461.99518127771 99477.19548329542 81837.70458447162 105427.74911846743 90644.99665645449 98163.48571090699 76118.90799910664 1.3187013296846537 1.3764433417813027 1.1732316006792374 1.3854901226711693 1.306865772226566 1.0751297770250736 1.3850402204890375 1.1908341703682657 1.2896071198506824 1.0 16.215967244424995 -14.126431219315112 0.19219280860352345 7.524739259034946e-11 1.3260492623364826 0.43848677141585934 0.09613126329961415 109.08841239544317 1.225058247219722 42.06261389484829 0.24822998035843738 7.474269973578988e-15 14.126431219315112 1.3260492622612352 EGPVLATSS(ph)GAGVFK ddPTM_A459_Selumetinib_30min_R1 1 EGPVLATSSGAGVFK 15 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 EGPVLAT(0.298)S(0.298)S(0.404)GAGVFK 78.529 0.032808 3137100.0 1571.3 1792.1 2017.2 1997.6 1920.8 1725.7 1751.9 1958.7 1366.3 1768.2 True False 1607.9082327824337 1582.2800988753131 1743.275319686457 1648.7566595961214 1747.0639791447823 1708.3410248102346 1619.7527725372174 1906.7489132457324 2318.511309396251 1995.1656937265268 0.805902105192686 0.7930569896277462 0.8737496465420902 0.8263758066712794 0.8756485662509836 0.856240176032414 0.8118387247887561 0.9556844923913805 1.1620645426524883 1.0 10.962292848448662 -7.990482942447417 4.006006859833854 1.079391421168322 0.8375509445794517 0.8262886720271407 0.04533296641027286 0.07686939380105842 2.791621291443012 0.028724105729941073 0.011526450905225343 1.0221557064758322e-08 7.990482942447417 -0.2418404765888703 EGPYSIS(ph)VLYGDEEVPR ddPTM_A459_Selumetinib_30min_R1 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 EGPYS(0.321)IS(0.679)VLYGDEEVPR 188.58 6.8364e-08 4157300.0 433.49 530.43 443.59 570.18 682.02 449.82 680.1 447.84 238.45 367.31 True False 443.5894735752925 468.3270090097827 383.35291446545483 470.60876660418285 620.3314114204109 445.295219203882 628.7995094483491 435.9618284106648 404.6322343010584 414.45781640238164 1.0702885939654423 1.1299750914942366 0.9249503792522802 1.1354804951905801 1.49672991284149 1.0744042012988881 1.5171616617259576 1.0518846820044183 0.9762929260530969 1.0 8.69508146118439 -5.997098621595954 24.949678983704846 1.2102309567470328 1.0471706523324067 0.10045035701869354 0.1846790260491796 180.32811682586086 1550642.7134818009 0.051887912282574264 0.076494671716416 1.0067030361202205e-06 5.997098621595954 -0.16306030441462616 EGPYSISVLYGDEEVPR ddPTM_A459_Selumetinib_30min_R1 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 175.01 2.1904e-06 9330700.0 1132.5 1389.9 1322.7 1261.9 1013.1 1343.2 1097.9 845.31 765.03 1112.7 False True 1158.8850465386035 1227.1698618530208 1143.0846050710263 1041.532853796728 921.4652838773328 1329.6886275280212 1015.0845190756395 822.8896328461478 1298.2000344195365 1255.5258836158278 0.9230276027453092 0.9774150241481733 0.9104428829288821 0.8295590456464229 0.7339277476491177 1.0590690680932917 0.8084935024615074 0.6554143117115854 1.0339890649492707 1.0 10.294076055827672 -5.546822107902598 5.274762124714703 0.859398155701524 0.9493525213081598 0.04802850472397402 0.12347572286722723 0.44490568477143144 34.7933304291904 0.033068888822146716 0.06093090140465679 2.8390817113635363e-06 5.546822107902598 0.08995436560663583 EGPYSISVLYGDEEVPR ddPTM_A459_Selumetinib_30min_R2 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 120.29 0.020394 6495300.0 34308.0 34318.0 28964.0 26490.0 26993.0 20813.0 27061.0 22211.0 17740.0 27573.0 False True 32401.298705805613 36950.08025023785 27100.487773618795 22882.016302201166 23601.898019518234 23679.801828397176 28319.390120354223 22275.63033277102 21288.495697014558 26776.895846742413 1.2100468587268096 1.379923963618549 1.0120847438302207 0.854543276157416 0.8814277112105794 0.8843370779021043 1.057605417836342 0.8318974111213492 0.7950322479072736 1.0 14.70870110324078 -5.417469983188697 4.075239462378539 0.9002164683400702 1.2918595907259633 0.7768015651191632 0.08317134180975853 0.09732692903785319 2.7714955519888593 0.022304085711768805 0.04907727577580314 3.824106835418237e-06 5.417469983188697 0.39164312238589316 EGPYSISVLYGDEEVPRS(ph)PFK ddPTM_A459_Selumetinib_30min_R1 3 EGPYSISVLYGDEEVPRSPFK 21 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 EGPYSIS(0.001)VLY(0.007)GDEEVPRS(0.992)PFK;EGPYSISVLYGDEEVPRS(1)PFK;EGPYSISVLYGDEEVPRS(1)PFK 110.53 5.97e-05 29997900.0 2943.56 3376.74 3745.1499999999996 3813.66 3269.57 2821.33 2938.5600000000004 2991.42 2274.2400000000002 2832.41 True False 3012.139220829289 2981.3897109961617 3236.5792006363918 3147.6758722643863 2973.837970789467 2792.9499817626784 2716.902053351771 2912.0778240984077 3859.219176082362 3195.977413509759 0.9424782566036403 0.9328569402253875 1.012704028180864 0.9848867701501278 0.9304940511214868 0.873895406756181 0.8501005175653362 0.9111697134619051 1.2075239204660848 1.0 11.642041497204383 -8.242644681694308 24.6954911808103 1.1037619680382498 0.9300231499599281 0.5387961589251204 0.06437082321680468 468.38439401981407 615441.2287836676 0.04514444674408977 0.016998158747969963 5.719463835983818e-09 8.242644681694308 -0.1737388180783217 EGPYSISVLYGDEEVPRS(ph)PFK ddPTM_A459_Selumetinib_30min_R2 2 EGPYSISVLYGDEEVPRSPFK 21 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 EGPYSISVLYGDEEVPRS(1)PFK;EGPYSISVLYGDEEVPRS(1)PFK 111.56 5.5421e-05 5902700.0 34835.0 38327.0 36693.0 37739.0 38958.0 30889.0 37509.0 31673.0 27562.0 43529.0 True False 32899.010155553726 41266.55765927111 34332.21232831769 32598.88309659378 34063.74775106107 35143.67936757605 39253.24282267346 31765.163186252594 33075.17014662432 42272.20466807564 0.7782657756764544 0.9762102067611343 0.8121699021353788 0.7711659080136116 0.8058190486758863 0.8313661339295341 0.9285828153722456 0.7514432577073971 0.7824330527904307 1.0 15.367421736317393 -10.956947140399537 4.893125768882335 1.0002907957491747 0.8290919286994403 0.3677801076581273 0.0682059137607486 0.00021981808048500144 2.5423872033426867e-05 0.06709233026378496 0.016244815677698407 1.1042130096053295e-11 10.956947140399537 -0.17119886704973442 EGQPSPADEKGNDS(ph)DGEGESDDPEK ddPTM_A459_Selumetinib_30min_R2 3 EGQPSPADEKGNDSDGEGESDDPEK 25 1 K7EKZ3;O75351 K7EKZ3 VPS4B Vacuolar protein sorting-associated protein 4B 1 EGQPSPADEKGNDS(0.942)DGEGES(0.058)DDPEK;EGQPSPADEKGNDS(0.959)DGEGES(0.041)DDPEK;EGQPS(0.001)PADEKGNDS(0.923)DGEGES(0.076)DDPEK 105.61 1.7637e-07 53783000.0 103622.5 79782.0 76432.1 74023.2 83950.2 63882.7 87492.6 85859.6 57124.9 76016.4 True False 97863.57628373378 85901.02286043698 71514.54189897834 63941.112462857476 73403.62535168979 72681.96205558775 91561.1792632979 86109.43722117809 68551.47620306582 73821.6090176734 1.3256765544124698 1.1636297827086333 0.968748078653464 0.8661571227409787 0.9943379225738151 0.9845621495216554 1.2403032185518679 1.1664529988849592 0.9286098896415834 1.0 16.17175556249358 -4.951542760468663 3.136088015742678 1.0256980143183902 1.3266317188383407 0.4634261292382965 0.10405392384400443 0.2787444767908455 5.102528844323389 0.030014921447956745 0.16997378706032076 1.1180397373996048e-05 4.951542760468663 0.3009337045199505 EGQPSPADEKGNDS(ph)DGEGESDDPEKK ddPTM_A459_Selumetinib_30min_R2 3 EGQPSPADEKGNDSDGEGESDDPEKK 26 2 K7EKZ3;O75351 K7EKZ3 VPS4B Vacuolar protein sorting-associated protein 4B 1 EGQPS(0.004)PADEKGNDS(0.982)DGEGES(0.014)DDPEKK;EGQPS(0.049)PADEKGNDS(0.95)DGEGES(0.001)DDPEKK;EGQPS(0.023)PADEKGNDS(0.804)DGEGES(0.174)DDPEKK 86.07600000000002 0.0017974 21502400.0 115296.0 99482.0 92250.0 82002.0 69374.0 57229.0 87441.0 85413.0 45668.5 82103.0 True False 108888.3098864569 107111.94951495292 86314.73543420556 70833.18613865993 60658.61790857105 65111.77527686264 91507.17976105439 85661.53768911657 54803.476084504524 79732.47306078757 1.3656707951782845 1.3433917876006607 1.0825543485701203 0.8883856654572488 0.7607768275583936 0.8166280660480931 1.1476776807272722 1.0743619807679703 0.6873419822651515 1.0 16.282879797395097 -5.409872837241133 2.58335545021631 0.9142903077370609 1.3669808974072502 0.6402156791686305 0.13197007675414033 0.19086240156259504 2.437568673546551 0.039227522942314845 0.10180546773800159 3.891590752870073e-06 5.409872837241133 0.45269058967018927 EGQPSPADEKGNDSDGEGES(ph)DDPEK ddPTM_A459_Selumetinib_30min_R2 1 EGQPSPADEKGNDSDGEGESDDPEK 25 1 K7EKZ3;O75351 K7EKZ3 VPS4B Vacuolar protein sorting-associated protein 4B 1 EGQPSPADEKGNDS(0.386)DGEGES(0.614)DDPEK 59.996 0.0040814 12312000.0 62677.0 49189.0 57228.0 54491.0 51388.0 46010.0 58864.0 55036.0 36902.0 50891.0 True False 59193.66325591051 52961.63813243627 53546.012785135186 47069.23179778192 44932.18002545118 52347.45986280471 61601.29263680322 55196.145648299724 44283.431128028875 49421.64459930249 1.197727508581249 1.0716284041503494 1.0834526697618416 0.9524011630816153 0.9091599518743116 1.0592010906804892 1.2464436004963022 1.1168415396900557 0.8960331346127213 1.0 15.592855399438733 -4.615430403967724 1.767232636534239 1.0383137025565408 1.3064072226501686 0.20049179437828013 0.09876715979513707 2.856769291034398 6.395079330092429 0.029532699694092498 1.4782072117637752 2.4242064144135315e-05 4.615430403967724 0.26809352009362786 EGQQSPEQWQK ddPTM_A459_Selumetinib_30min_R1 1 EGQQSPEQWQK 11 0 Q6UVM3-4 Q6UVM3-4 0 88.49600000000002 0.042944 13244000.0 2944.8 3136.0 3353.8 3046.7 3072.3 2727.7 2807.8 2582.3 1559.7 2519.6 False True 3013.408110416671 2768.8356621131516 2898.3723811047166 2514.6510386421205 2794.411007458621 2700.2618145534416 2596.0053854272523 2513.809015507456 2646.6969840191277 2843.0152029823303 1.0599338713544684 0.9739081448486929 1.0194712916288018 0.8845014391777593 0.9829039973220252 0.949788031988313 0.9131169550919165 0.8842052666023256 0.9309471793336651 1.0 11.473206098488843 -3.440619230017019 0.576494929559946 0.9289119121109272 1.5723300691647473 0.42675388477832243 0.04176774917488892 14.10530444907306 1.0698779603768807 0.019654554085711828 8.546062722275922 0.0003625607361493849 3.440619230017019 0.6434181570538201 EGQSPASQAGTQHPPAQATAHS(ph)QSSPEFK ddPTM_A459_Selumetinib_30min_R1 1 EGQSPASQAGTQHPPAQATAHSQSSPEFK 29 0 H0YJ83;A0A087WWY9;Q8TB24-4;Q8TB24 H0YJ83 RIN3 Ras and Rab interactor 3 1 EGQSPASQAGTQHPPAQAT(0.355)AHS(0.522)QS(0.114)S(0.009)PEFK 89.92299999999999 1.207e-06 6096700.0 1270.9 1111.5 1404.4 1752.9 1565.8 1408.9 1746.9 1397.9 622.03 1186.3 True False 1300.509497259082 981.3650632776688 1213.6901938170038 1446.7889210082299 1424.1736664644432 1394.7277451788484 1615.129926562742 1360.8231509808595 1055.5394787263042 1338.573160540538 0.9715640023246206 0.7331426418869607 0.906704414517691 1.080844113461824 1.0639490678935608 1.0419510761859547 1.206605641122018 1.016622169856847 0.7885556873858578 1.0 10.38648027718173 -5.6107529047649445 4.953780146449161 1.0378141531626681 0.8448837200864843 0.30052813360799246 0.11132155699684486 0.22505577477139924 9.406701229502673 0.031045341562492387 0.055341231093416314 2.450457051962587e-06 5.6107529047649445 -0.19293043307618385 EGQSPASQAGTQHPPAQATAHS(ph)QSSPEFK ddPTM_A459_Selumetinib_30min_R2 1 EGQSPASQAGTQHPPAQATAHSQSSPEFK 29 0 H0YJ83;A0A087WWY9;Q8TB24-4;Q8TB24 H0YJ83 RIN3 Ras and Rab interactor 3 1 EGQSPASQAGTQHPPAQAT(0.027)AHS(0.324)QS(0.324)S(0.324)PEFK 62.404 0.00099868 7597600.0 18674.0 17146.0 18552.0 26355.0 27707.0 18066.0 15900.0 16605.0 14356.0 22280.0 True False 17636.173837944894 18461.0430669205 17358.384517890347 22765.403535089154 24226.198956277247 20554.427513180373 16639.38150525229 16653.317800894278 17227.601140154526 21636.718509607963 0.8151039091308326 0.8532274919009888 0.8022651175215046 1.052165259023913 1.1196799064294063 0.9499789676541297 0.7690344308848607 0.7696785348249198 0.7962206067664312 1.0 14.401194091796526 -10.733083334335472 6.386268190602186 1.0000010374155488 0.8852380111956083 0.08563223817491761 0.11602949168272743 1.953253217881676e-06 2.4169394407296035e-07 0.12803843757871364 0.031053602074605453 1.848913807223799e-11 10.733083334335472 -0.1147630262199405 EGQSPASQAGTQHPPAQATAHSQS(ph)SPEFK ddPTM_A459_Selumetinib_30min_R2 1 EGQSPASQAGTQHPPAQATAHSQSSPEFK 29 0 H0YJ83;A0A087WWY9;Q8TB24-4;Q8TB24 H0YJ83 RIN3 Ras and Rab interactor 3 1 EGQSPASQAGTQHPPAQAT(0.002)AHS(0.248)QS(0.375)S(0.375)PEFK 97.124 7.8527e-08 8076200.0 18848.0 14937.0 20635.0 21318.0 20232.0 13892.0 17687.0 15218.0 13241.0 17155.0 True False 17800.503614522084 16082.619869975017 19307.366565689248 18414.451624398804 17690.275283625135 15805.496900979853 18509.480546125607 15262.281860524487 15889.569984451524 16659.690575957127 1.068477444605805 0.9653612590611421 1.1589270807678256 1.105329750300051 1.061860975326596 0.9487269183612554 1.1110338731523652 0.9161203679587334 0.9537734156589305 1.0 14.02407398501415 -7.351289077151247 1.046055563758583 0.9603368357654162 1.0690965185373407 0.26251318411285873 0.06751631695114306 0.7353924906805094 1.5354462222734429 0.051337606826961264 0.027123058487972987 4.453597072768989e-08 7.351289077151247 0.10875968277192449 EGQWDCS(ph)VCLVR ddPTM_A459_Selumetinib_30min_R2 1 EGQWDCSVCLVR 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 EGQWDCS(1)VCLVR 87.863 0.033791 0.0 6181.4 5798.8 8354.4 7195.6 6308.4 8462.3 9342.5 6848.6 6845.8 7020.8 True False 5837.862534104778 6243.549313919203 7816.886999582955 6215.546866897647 5515.882394188454 9627.905011888983 9776.944761812547 6868.52829215324 8215.151287633731 6818.091261770896 0.8562312104617504 0.91573272844364 1.1464919871947616 0.9116256483318548 0.8090068293916891 1.4121114901868121 1.433970943837606 1.007397529373821 1.20490485859234 1.0 12.735152195084963 -6.75449981257904 24.99545586136475 1.2260326892530307 0.9383953108700314 0.44902153185057947 0.1565979197238386 159.4554234430989 574337.9916393997 0.05442662406449953 0.05329626291473625 1.7599494233122483e-07 6.75449981257904 -0.2876373783829993 EGRGES(ph)ENAGTNQETR ddPTM_A459_Selumetinib_30min_R1 1 EGRGESENAGTNQETR 16 1 Q08170 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 1 EGRGES(0.999)ENAGT(0.001)NQETR 105.91 0.0019721 1547100.0 150.92 222.14 160.37 188.04 192.78 224.26 181.48 169.46 113.04 133.49 True False 154.4361423608 196.13174552991575 138.59263484935403 155.2023439479648 175.3430830380734 222.00414801178832 167.79081748961374 164.96537031634352 191.82062388505614 150.62474180271133 1.025303947495431 1.3021217044594813 0.9201186550804715 1.0303907717315741 1.1641054513324127 1.473888986329815 1.1139658430710313 1.0952076554090668 1.2735001009084104 1.0 7.234814958086504 -2.957415630017114 12.032458791281542 1.1471002337467593 0.43275508396366336 0.0 0.15890057465692486 0.0 0.0 0.036752205994316556 0.0 0.0011030224961854917 2.957415630017114 -0.7143451497830959 EGRGES(ph)ENAGTNQETR ddPTM_A459_Selumetinib_30min_R2 2 EGRGESENAGTNQETR 16 1 Q08170 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 1 EGRGES(0.789)ENAGT(0.211)NQETR;EGRGES(0.979)ENAGT(0.021)NQETR 200.9 3.1194e-06 11399900.0 7088.4 9491.5 10640.3 9605.2 9459.8 7302.4 4761.799999999999 3616.33 4141.200000000001 7464.8 True False 6694.455105113452 10219.467530017258 9955.71468228269 8296.955190105798 8271.375352314999 8308.239315412842 4983.233135327695 3626.852921584339 4969.55571479576 7249.271828120359 0.9234658685504468 1.409723317364833 1.3733399599755494 1.1445225654142825 1.1409939575213388 1.1460791528308658 0.6874115433218321 0.5003058248575477 0.6855248130603347 1.0 12.823620371828348 -7.231413590242316 4.068732111157847 0.6717734518156732 1.2099777423609335 0.6403497240339832 0.17188801633154235 0.1273276189360122 4.82679322023685 0.07039842715951855 0.051102336169363244 5.869301370379835e-08 7.231413590242316 0.5382042905452603 EGRPSGEAFVELES(ph)EDEVK ddPTM_A459_Selumetinib_30min_R1 2 EGRPSGEAFVELESEDEVK 19 1 P31943;G8JLB6;E9PCY7;D6RBM0;E7EN40;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;D6RDL0;E7EQJ0 P31943;E7EQJ0 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 EGRPSGEAFVELES(1)EDEVK;EGRPSGEAFVELES(1)EDEVK 143.47 4.1249e-05 72756000.0 7283.099999999999 8608.6 6598.3 7142.599999999999 6339.2 7182.6 7582.400000000001 7452.799999999999 4713.2 7319.8 True False 7452.782059554347 7600.701109970435 5702.287101867514 5895.278993207471 5765.820479276662 7110.349565279009 7010.453463374738 7255.127533893803 7997.95616149192 8259.367630889854 0.9023429386628954 0.9202521851120877 0.6904023838993539 0.7137688085416197 0.6980946649853216 0.8608830461410214 0.8487881611124556 0.8784119872276643 0.9683496992650793 1.0 13.011815612226476 -7.978650121181707 1.1255856046756885 0.9992387552668117 0.7895805895542607 0.47809090119401954 0.07651634940233772 0.47576097851680693 1.0984255660174116 0.07795378851978549 0.027849240844319563 1.050388307745224e-08 7.978650121181707 -0.20965816571255103 EGRPSGEAFVELES(ph)EDEVK ddPTM_A459_Selumetinib_30min_R2 4 EGRPSGEAFVELESEDEVK 19 1 P31943;G8JLB6;E9PCY7;D6RBM0;E7EN40;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;D6RDL0;E7EQJ0 P31943;E7EQJ0 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 EGRPSGEAFVELES(1)EDEVK;EGRPSGEAFVELES(1)EDEVK;EGRPSGEAFVELES(1)EDEVK;EGRPSGEAFVELES(1)EDEVK 147.0 2.3843e-05 37507400.0 167501.0 146729.0 158077.0 161880.0 160618.0 127659.0 136952.0 142762.0 110846.0 145451.0 True False 158191.9649796298 157982.64249190324 147906.4979212244 139831.66474142423 140439.73089686144 145242.8684769786 143320.53936523982 143177.4137844786 133018.2972960133 141251.45170291697 1.119931604755061 1.1184496908688462 1.0471148872317748 0.9899485141966622 0.9942533630892322 1.0282575274515158 1.0146482576807394 1.013634989646778 0.9417127802394569 1.0 17.107906169248437 -5.42435580158296 2.607056416907233 0.9999791952095407 1.1219727808785793 0.8274192519996799 0.022054651879868995 0.11209795985060908 1.4627193606530025 0.006301267715121465 0.015993251713812474 3.7639530572672962e-06 5.42435580158296 0.12199358566903862 EGRPSGEAFVELESEDEVK ddPTM_A459_Selumetinib_30min_R1 2 EGRPSGEAFVELESEDEVK 19 1 P31943;G8JLB6;E9PCY7;D6RBM0;E7EN40;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;D6RDL0;E7EQJ0 P31943;E7EQJ0 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 ; 169.43 1.2329e-08 4074000.0 2049.2 2306.77 3193.0 2914.2 2371.26 2390.82 2324.27 2154.85 1995.08 2007.09 False True 2096.9423729509094 2036.6922960117215 2759.4081378935425 2405.289676309077 2156.779951679955 2366.770521490876 2148.9484426194863 2097.6963780607375 3385.505045122062 2264.71955221218 0.9259170173642975 0.8993132478687167 1.2184326024819057 1.0620695502715063 0.9523386458924729 1.0450611949629756 0.9488805978296039 0.9262499526759089 1.494889308398074 1.0 11.145116692247855 -8.231328611956798 24.98910468088996 1.247444969040025 1.0020294666392895 0.33087639228145915 0.14217063036553387 661.0717105094947 548628.9831181361 0.09196135011895676 0.03474891342812852 5.870449927379849e-09 8.231328611956798 -0.24541550240073562 EGS(ph)EFSFSDGEVAEK ddPTM_A459_Selumetinib_30min_R1 1 EGSEFSFSDGEVAEK 15 0 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 EGS(0.984)EFS(0.016)FSDGEVAEK 202.01 1.3998e-05 4702800.0 752.15 723.4 805.48 848.6 682.96 528.74 790.8 520.51 441.67 646.37 True False 769.6736315708695 638.7039917004643 696.100240184933 700.4079401948677 621.1863885863816 523.421355657509 731.1493193232674 506.7043839452377 749.4817316995112 729.3378856769685 1.0553046080370025 0.8757312683786086 0.9544276443816099 0.9603339603629008 0.8517127668608615 0.717666483445696 1.0024836686560132 0.6947457329395643 1.0276193605434951 1.0 9.510443527039074 -1.5228850249546266 0.8261610254877099 0.8787689190100465 48.15429667663811 0.12393019770856728 0.11225840927616786 1112.1896442686825 3.4452520761883747 0.037249495134216076 98637.09852984654 0.02999956621860393 1.5228850249546266 47.27552775762806 EGS(ph)FESR ddPTM_A459_Selumetinib_30min_R2 2 EGSFESR 7 0 V9GY71;V9GYH5;P19174;P19174-2 V9GY71;P19174-2 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1 EGS(1)FESR;EGS(1)FESR 106.68 0.017016999999999997 8975200.0 134643.0 93401.0 111135.0 133561.0 108519.0 69189.0 151749.0 112249.0 90097.0 90249.0 True False 127160.08107863425 100564.55636845001 103984.695094639 115369.76139442394 94885.87304783096 78719.1567147922 158805.62918493882 112575.62600617758 108118.91752051411 87643.27687493776 1.4508823222126308 1.1474303558041334 1.186453756664297 1.316356091512306 1.0826372133852091 0.8981767857347485 1.811954491518453 1.2844753188178593 1.2336247727797078 1.0 16.41935580548921 EGS(ph)GGPQESSR ddPTM_A459_Selumetinib_30min_R2 2 EGSGGPQESSR 11 0 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 EGS(1)GGPQESSR;EGS(1)GGPQESSR 156.52 0.00054829 18417900.0 21481.9 15675.1 15744.7 15776.8 15178.199999999999 16611.7 26172.0 43992.0 17266.2 26225.0 True False 20288.021996859203 16877.329766609448 14731.703143533197 13627.972623501975 13271.378821170374 18899.81088900136 27389.04985883414 44120.00943673236 20719.922457936485 25467.816109267 0.7966141230883546 0.6626924622904072 0.5784439105547318 0.5351056629682178 0.5211039205022885 0.7421056759603454 1.0754377109259894 1.7323829121209324 0.8135727998443143 1.0 14.636387631921124 -7.268408477490686 3.3126011058105025 1.2329207561440798 0.6184813205603714 0.5410341535424429 0.23308488038477884 0.16830332385708505 3.8829458895074436 0.09784703720584244 0.06716512768790027 5.39003422105617e-08 7.268408477490686 -0.6144394355837084 EGS(ph)IETLSNSSGSTSGSIPR ddPTM_A459_Selumetinib_30min_R2 1 EGSIETLSNSSGSTSGSIPR 20 0 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6;Q9H6U6-8;Q9H6U6-3 K7ESE9;Q9H6U6-8 BCAS3 Breast carcinoma-amplified sequence 3 1 EGS(0.955)IET(0.044)LS(0.001)NSSGSTSGSIPR 75.483 0.0060602 3632900.0 30661.0 25916.0 26506.0 33882.0 28847.0 22665.0 18437.0 20564.0 14078.0 33237.0 True False 28956.984365707878 27903.673866925925 24800.63281755073 29267.213150289914 25222.981964547955 25786.898017615047 19294.357032222422 20623.837835446546 16893.99337218553 32277.36144990306 0.8971298478238793 0.8644967436459937 0.7683599806026032 0.9067411905931305 0.7814449766501502 0.7989159230886419 0.5977674805348865 0.6389567458125821 0.5234006936535474 1.0 14.978235028217059 -7.079216261096955 3.527183136015513 0.6604817638844106 0.8417242953852596 0.23756291765898085 0.1249316822493391 0.2933154807100309 6.971531263407114 0.047141866734964746 0.03656131466814472 8.332661484329163e-08 7.079216261096955 0.181242531500849 EGS(ph)LSPVNSQK ddPTM_A459_Selumetinib_30min_R1 1 EGSLSPVNSQK 11 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 EGS(0.893)LS(0.105)PVNS(0.003)QK 123.26 0.003915 12038000.0 3903.3 4102.8 4745.4 4661.8 4695.7 4189.0 4739.7 4467.3 2536.5 3556.7 True False 3994.239295500335 3622.4422686600283 4101.000744616351 3847.704142823986 4270.974764093168 4146.862463307684 4382.180613045638 4348.812692164531 4304.255241369825 4013.237090191802 0.9952662167062353 0.9026235398634032 1.0218685446317237 0.9587532598628742 1.0642218907353536 1.0332961572199304 1.0919316538152006 1.0836171884269838 1.0725145673275223 1.0 11.970550673458824 -6.232399822052577 1.441118049503461 1.0668089301530579 0.9600880828519768 0.5217105449203951 0.039485221100076275 0.2883911983963791 1.2015167422285882 0.013972870165358574 0.019875570242892257 5.855987997919541e-07 6.232399822052577 -0.10672084730108111 EGS(ph)PANWK ddPTM_A459_Selumetinib_30min_R1 2 EGSPANWK 8 0 O96019-2;O96019 O96019-2 ACTL6A Actin-like protein 6A 1 EGS(1)PANWK;EGS(1)PANWK 102.53 0.016148 96225000.0 12310.7 13862.8 12502.3 13396.7 10990.1 11887.8 11700.9 11606.2 7437.4 11184.1 True False 12597.515357547718 12239.736931359126 10804.556330218116 11057.217832204315 9996.047395459755 11768.219525258788 10818.291692551367 11298.365873749233 12620.724593796138 12619.688177359376 0.998242997806282 0.9698921842869375 0.8561666642130084 0.8761878801444362 0.7920993969877465 0.9325285506159983 0.8572550716395796 0.8952967549562207 1.0000821269449922 1.0 13.623388642442405 -10.460706339106114 5.978516277398509 1.0000000431666018 0.9033141584009107 0.1498386077451056 0.06416759392251177 3.836727766275327e-08 6.841974550657396e-09 0.06459005248729563 0.015665381864883456 3.4617337393944896e-11 10.460706339106114 -0.09668588476569118 EGS(ph)PANWK ddPTM_A459_Selumetinib_30min_R2 4 EGSPANWK 8 0 O96019-2;O96019 O96019-2 ACTL6A Actin-like protein 6A 1 EGS(1)PANWK;EGS(1)PANWK;EGS(1)PANWK;EGS(1)PANWK 107.45 0.013294 127550000.0 550385.0 492283.0 503860.0 472012.0 477244.0 400087.0 474829.0 429649.0 330082.0 444671.0 True False 519796.80506572215 530039.5231606693 471442.19616128935 407723.1513338842 417288.3421045076 455195.35262181994 496909.489355814 430899.20745777874 396107.62326166674 431832.1928359921 1.203700913662865 1.2274201228021364 1.091725452577226 0.9441703469494124 0.9663205963502398 1.0541024040667137 1.1507004285447935 0.9978394723837375 0.9172721020642076 1.0 18.720111273873172 -5.43785557329657 3.627455800566569 1.0108410783176605 1.214057894175196 0.6492839219880272 0.06147508653640278 0.1594355927077548 3.907281948969796 0.018306819271519812 0.04073752690851509 3.648752677639141e-06 5.43785557329657 0.2032168158575356 EGS(ph)PAPLEPEPGAAQPK ddPTM_A459_Selumetinib_30min_R1 2 EGSPAPLEPEPGAAQPK 17 0 Q01167-2;Q01167 Q01167-2 FOXK2 Forkhead box protein K2 1 EGS(1)PAPLEPEPGAAQPK;EGS(1)PAPLEPEPGAAQPK 99.313 0.0032003 23496000.0 11313.7 12333.2 9447.2 8378.2 7903.700000000001 8628.599999999999 10414.900000000001 11619.2 6411.1 12216.8 True False 11577.287197372003 10889.223210450877 8164.322129755046 6915.104648292056 7188.811730511569 8541.804118141961 9629.295707915902 11311.02107151929 10879.168451782409 13784.94528170922 0.8398500654720418 0.7899359038370228 0.5922636588618172 0.5016417916048949 0.52149729894468 0.6196472995417539 0.6985371005202821 0.8205343467360369 0.7892065024166335 1.0 13.750805920240794 -8.288412849922874 1.0192996975155593 0.9825943625940485 0.6386429856675786 0.512845388582809 0.10502245617923912 0.45297981008723515 0.9803069652030135 0.11249875733989842 0.03847597740037791 5.147390895847322e-09 8.288412849922874 -0.34395137692646993 EGS(ph)PAPLEPEPGAAQPK ddPTM_A459_Selumetinib_30min_R2 3 EGSPAPLEPEPGAAQPK 17 0 Q01167-2;Q01167 Q01167-2 FOXK2 Forkhead box protein K2 1 EGS(1)PAPLEPEPGAAQPK;EGS(1)PAPLEPEPGAAQPK;EGS(1)PAPLEPEPGAAQPK 149.31 0.00030624 82275700.0 593586.0 515597.0 544961.0 590792.0 481153.0 461328.0 653790.0 618856.0 480357.0 449730.0 True False 560596.866433028 555141.6319943424 509898.80256867263 510325.110426955 420706.2585776039 524871.7444813724 684192.5304603087 620656.7685028742 576441.8222959888 436745.1263611298 1.2835789859953455 1.2710883270058853 1.1674974070507533 1.1684735092040486 0.9632763668889486 1.201780427075387 1.5665716436514348 1.4210960375770147 1.3198586257820046 1.0 18.736432078634692 -7.02711994717258 24.631332828685636 1.3651448259361876 1.166692986622205 0.16816219653303444 0.15653362172115667 843.7813098135911 766350.65558313 0.05908274909857819 0.04590552722345638 9.394638055636668e-08 7.02711994717258 -0.19845183931398247 EGS(ph)PGSQQHPPSQK ddPTM_A459_Selumetinib_30min_R1 2 EGSPGSQQHPPSQK 14 0 Q13796 Q13796 SHROOM2 Protein Shroom2 1 EGS(0.991)PGS(0.009)QQHPPSQK;EGS(1)PGSQQHPPSQK 120.99 0.0013133 13466200.0 6011.0 6384.0 6501.4 7188.9 6947.6 5626.5 6215.5 5498.5 2201.2 4494.0 True False 6151.044604630057 5636.558312158915 5618.545589633911 5933.493567366111 6319.190806698406 5569.902518453252 5746.659830872238 5352.661918354863 3735.2756307128916 5070.84867526695 1.2130207384479368 1.1115611356440616 1.108008925022423 1.1701184451247204 1.2461801192215105 1.0984162366391323 1.1332737770112438 1.0555751632783792 0.736617452011867 1.0 12.308011506670777 -8.045837771494666 4.464038193241826 0.8689606938655577 1.1505377035034148 0.69825699532761 0.07426237215192001 0.11076220166448282 4.763139874506043 0.04975981296154173 0.018573509732743344 8.99833647062277e-09 8.045837771494666 0.28157700963785703 EGS(ph)PGSQQHPPSQK ddPTM_A459_Selumetinib_30min_R2 1 EGSPGSQQHPPSQK 14 0 Q13796 Q13796 SHROOM2 Protein Shroom2 1 EGS(0.868)PGS(0.131)QQHPPS(0.001)QK 94.61 0.008651700000000002 10687000.0 44344.0 33399.0 44975.0 50556.0 42547.0 35972.0 34845.0 39691.0 28351.0 48126.0 True False 41879.538003096764 35960.59590528858 42081.35746507749 43670.18558603557 37201.86548499399 40926.81647869616 36465.361544057596 39806.494238801206 34021.99219312629 46736.47733363525 0.8960781897217776 0.7694331699109146 0.9003964326338397 0.934391894243323 0.795992073159964 0.8756932232297704 0.7802334198990699 0.8517221774041005 0.7279537126911656 1.0 15.5122613775808 -6.298555946056315 24.98083202538431 0.8301216412221907 0.8693378665874046 0.04108756380865075 0.07834961255569119 1849.464413805376 1244753.8661370114 0.02324444285148615 0.026357302624722724 5.028564834264582e-07 6.298555946056315 0.039216225365213964 EGS(ph)PIPHDPEFGSK ddPTM_A459_Selumetinib_30min_R1 4 EGSPIPHDPEFGSK 14 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK 210.34 4.4692e-06 525917000.0 33316.3 37465.5 30403.8 29308.9 28238.8 28745.3 34610.3 35147.9 19081.1 34205.8 True False 34092.504967765184 33079.021842761606 26275.130956118905 24190.65081119179 25684.60552596508 28456.148380644154 31999.617206087627 34215.66351553057 32379.23307159539 38596.44762270719 0.8833068084666883 0.8570483523799856 0.6807655257024389 0.6267584791134992 0.6654655313628974 0.7372737682703924 0.8290819279249293 0.8864977380820068 0.838917441006823 1.0 15.236180448987204 -7.535485470905147 2.0517899184763624 0.9042477099929154 0.7352226918793825 0.44516829033518734 0.08371019385545596 0.3657755448563432 3.0468513092658536 0.05599516425000502 0.02853332880857951 2.9141676250944882e-08 7.535485470905147 -0.16902501811353288 EGS(ph)PIPHDPEFGSK ddPTM_A459_Selumetinib_30min_R2 7 EGSPIPHDPEFGSK 14 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK;EGS(1)PIPHDPEFGSK 151.11 0.00026996 1326790500.0 1108080.0 918528.0 1014234.0 990103.0 940920.0 771596.0 1020332.0 997570.0 733564.0 838962.0 True False 1046497.3495956927 988976.1440669762 948979.2886544839 855249.2633770597 822713.2176684743 877876.3451488948 1067779.4597495017 1000472.7635433967 880297.2974906877 814738.9871749447 1.2844571894421737 1.2138564124643005 1.1647647941152401 1.0497217843257776 1.0097874664390123 1.077493969194815 1.3105785736999755 1.2279672131715116 1.080465414504174 1.0 19.635978420626827 -5.136519943079685 2.1760425200541516 1.1208753496490012 1.2796810899091313 0.2735862672430316 0.09175252103514846 0.5899268449049748 4.877764436366055 0.0278430363555062 0.1347898508225804 7.302642779018538e-06 5.136519943079685 0.15880574026013017 EGS(ph)QGELTPANSQSR ddPTM_A459_Selumetinib_30min_R1 3 EGSQGELTPANSQSR 15 0 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 EGS(0.588)QGELT(0.412)PANSQSR;EGS(0.999)QGELT(0.001)PANSQSR;EGS(0.998)QGELT(0.001)PANS(0.001)QS(0.001)R 226.06 1.2041e-13 34443600.0 4178.58 5536.0 3769.7100000000005 4060.17 3563.5000000000005 4380.8 4218.400000000001 4258.17 3009.32 4062.36 True False 4275.9327838987 4887.8425463834255 3257.804087534817 3351.1375283301863 3241.182054187024 4336.733129448148 3900.2026917466774 4145.229499114508 5106.596247963352 4583.803476737299 0.932835102028035 1.0663289932016322 0.7107207156825331 0.7310822868687837 0.7070944621941038 0.9460992713708108 0.8508660354965302 0.9043209466006682 1.11405217825747 1.0 12.16232947683408 -8.094967576173266 4.067651247389895 1.0544657932841008 0.8473021290350926 0.35003119392053494 0.11129100981194809 0.2832641326117385 8.087331741258685 0.08955641460373914 0.03151168869248153 8.035861145765571e-09 8.094967576173266 -0.20716366424900823 EGS(ph)QGELTPANSQSR ddPTM_A459_Selumetinib_30min_R2 2 EGSQGELTPANSQSR 15 0 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 EGS(1)QGELTPANSQSR;EGS(1)QGELTPANSQSR 170.48 5.2266e-05 58501000.0 44468.0 33420.0 36097.0 38403.0 33524.0 30021.0 35456.0 39040.0 26579.0 27722.0 True False 41996.6465795081 35983.20653776291 33774.55831944198 33172.44515112988 29312.41541163745 34156.120246495535 37104.77425473116 39153.599936580074 31895.542679309478 26921.593829593912 1.559961376927942 1.3365927279612957 1.2545527034255624 1.2321872680013708 1.0888068365185495 1.2687257843162678 1.3782532523740572 1.4543566842443025 1.1847568491375087 1.0 14.71647620339011 -8.530557182834519 22.00890797591087 0.9999999913581561 1.3099544579523605 0.4027170313070294 0.12184126947748511 204.1102523234668 585049.8184119241 0.12631030458000245 0.03261318039992902 2.9474253684438717e-09 8.530557182834519 0.30995446659420445 EGSALSHVR ddPTM_A459_Selumetinib_30min_R2 1 EGSALSHVR 9 0 K7ELG9;Q3MHD2;Q3MHD2-2 K7ELG9 LSM12 Protein LSM12 homolog 0 97.565 0.028772 1371900.0 17080.0 13393.0 22882.0 21407.0 24563.0 15451.0 15774.0 16886.0 15882.0 20528.0 False True 16130.76197665732 14420.200034717507 21409.797032037866 18491.32967086523 21477.17634399388 17579.234999786888 16507.52225558803 16935.135464372222 19058.843780157025 19935.30330185064 0.8091555835601391 0.7233499193051579 1.0739639476691758 0.927567009685207 1.0773438466822878 0.8818142735834357 0.8280547331354421 0.8495047809380505 0.9560348037638208 1.0 14.283037934658815 -5.241610842903441 24.98590188191579 0.9409691065749815 0.76625272773266 0.43653490204589396 0.08274837298016409 828.5078998577052 1043997.6313121301 0.022214855775828712 0.058608956474322925 5.733095248237557e-06 5.241610842903441 -0.1747163788423215 EGSCIFPEELS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EGSCIFPEELSPK 13 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 EGSCIFPEELS(1)PK;EGSCIFPEELS(1)PK 194.3 0.00019324 39810000.0 6882.0 9503.6 9804.3 9487.5 6622.4 7799.1 7314.0 6789.4 5025.7 7208.299999999999 True False 7042.3372099590915 8390.914093896226 8472.929911164943 7830.686227432019 6023.4050892796795 7720.648135016218 6762.29909146482 6609.323056920703 8528.245837394961 8133.555519787883 0.8658374794179496 1.0316415832512882 1.0417252197457074 0.962762989492231 0.7405623622566438 0.9492340854172427 0.8314075037679433 0.8125994887280328 1.0485261724281403 1.0 12.989670437630945 -6.02030914820031 24.5515476924948 0.8837979641502207 0.9878119106203815 0.12870722967214965 0.09641371767959744 952.9099168869922 1151964.9439737364 0.02735766797392566 0.03579616378646368 9.543130259608581e-07 6.02030914820031 0.10401394647016082 EGSCIFPEELS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 EGSCIFPEELSPK 13 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 EGSCIFPEELS(1)PK;EGSCIFPEELS(1)PK 161.21 0.00036373 7153900.0 38820.0 39042.0 37430.0 36384.0 31641.0 28424.0 34983.0 36203.0 24819.0 34594.0 True False 36662.53980877267 42036.39586018376 35021.794550702645 31428.436434099174 27665.974705871038 32339.147992618142 36609.77881749943 36308.3447362707 29783.493500800716 33595.18133399363 1.0913035248800789 1.2512626570539984 1.0424648166808816 0.9355042951441964 0.8235102061460504 0.9626126935024293 1.0897330320540777 1.0807604928606749 0.8865406382153974 1.0 15.035966696955521 -5.4739171085948755 5.055236717805169 0.9713342309785173 1.1693277359732206 0.4791798596150413 0.08377270839286281 0.18295813669994818 10.507327722120714 0.024088290756897737 0.05003235948276715 3.3580170075517978e-06 5.4739171085948755 0.19799350499470325 EGSEFS(ph)FSDGEVAEK ddPTM_A459_Selumetinib_30min_R1 2 EGSEFSFSDGEVAEK 15 0 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 EGSEFS(0.653)FS(0.347)DGEVAEK;EGS(0.354)EFS(0.646)FSDGEVAEK 233.28 3.4456999999999996e-14 4055800.0 1074.79 1044.0 1051.41 1007.22 930.31 939.16 1000.27 669.4200000000001 514.58 905.9300000000001 True False 1099.8305158227154 921.7679946575678 908.6342969817255 831.3279348610353 846.1636247595704 929.7129030890534 924.8188285780026 651.6648070173883 873.2046765638026 1022.2149400054706 1.0759288216006992 0.9017359838750104 0.888887709836116 0.8132613820500278 0.8277746603420236 0.9095082322745918 0.9047205165804496 0.6375027222884267 0.8542280516455076 1.0 9.997482866726518 -2.8777120970601655 0.967772555899378 0.8382001912270859 10.417583891137816 0.35423109540979403 0.08856128539883992 74.47083872495432 2.2554167062300183 0.028426220940663424 1475.2336470530347 0.0013252197600973935 2.8777120970601655 9.57938369991073 EGSEFSFS(ph)DGEVAEK ddPTM_A459_Selumetinib_30min_R1 2 EGSEFSFSDGEVAEK 15 0 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 EGSEFS(0.011)FS(0.989)DGEVAEK;EGSEFS(0.012)FS(0.988)DGEVAEK 159.31 0.00013865 8385200.0 2206.4 1972.53 1794.78 2522.37 2006.87 1651.0300000000002 1659.97 1575.5900000000001 955.1 1531.06 True False 2257.804827092956 1741.5852705956809 1551.0587340208492 2081.885430249031 1825.348962841676 1634.422137215298 1534.7571264504859 1533.8002349623966 1620.7349422559894 1727.5864647873188 1.30691277867294 1.0081030999569016 0.8978182948497447 1.2050832028863627 1.05658906228256 0.9460725529685774 0.8883822359880714 0.8878283467862322 0.9381498265301101 1.0 10.754542203205103 -6.7577451055140045 3.7639194303565318 0.9195170559664605 1.0877924288372205 0.370359959296779 0.10643458370674064 0.2599383734233557 7.99288799700841 0.038498329918627235 0.0360315721426441 1.7468471050518386e-07 6.7577451055140045 0.16827537287076 EGSEFSFS(ph)DGEVAEK ddPTM_A459_Selumetinib_30min_R2 3 EGSEFSFSDGEVAEK 15 0 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 EGSEFS(0.005)FS(0.995)DGEVAEK;EGSEFSFS(1)DGEVAEK;EGS(0.001)EFS(0.079)FS(0.92)DGEVAEK 218.34 2.8662e-09 45385000.0 248393.0 234465.0 242476.0 228788.0 248400.0 185752.9 206373.0 226212.7 168749.5 208936.0 True False 234588.31145596263 252447.7115761992 226875.35814790762 197626.6797186859 217193.77127582446 211338.67587806055 215969.7534203416 226870.94150547142 202504.11525498042 202903.47479907793 1.156157190941457 1.2441763839982616 1.1181442721597916 0.9739935696733765 1.070429037703259 1.0415724821240022 1.064396524673628 1.1181225049503312 0.9980317757273849 1.0 17.63043404644352 -5.514026099185983 6.123906726500909 1.0453367193501881 1.1967258401218883 0.6825369841165816 0.04429629994607806 0.08303600726734126 12.918122514148475 0.011519507708896155 0.02216286024999811 3.0617794287004102e-06 5.514026099185983 0.1513891207717002 EGSIETLSNSSGSTS(ph)GSIPR ddPTM_A459_Selumetinib_30min_R1 1 EGSIETLSNSSGSTSGSIPR 20 0 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6;Q9H6U6-8;Q9H6U6-3 K7ESE9;Q9H6U6-8 BCAS3 Breast carcinoma-amplified sequence 3 1 EGS(0.01)IETLS(0.025)NS(0.025)S(0.004)GS(0.045)T(0.014)S(0.753)GS(0.124)IPR 138.28 8.639100000000001e-05 5606400.0 841.98 1304.3 1199.3 1237.3 1068.0 1003.5 1233.0 1021.3 461.16 1033.8 True False 861.5964957921176 1151.591949647381 1036.4416472833468 1021.2287819975367 971.3995885707151 993.405701105099 1139.9938173060052 994.2118063500628 782.5548382062326 1166.4983000647467 0.7386178751776102 0.9872212840631329 0.8885067789861494 0.8754652980984654 0.8327483962186635 0.8516135008940517 0.9772785928987034 0.8523045479748054 0.670858104261958 1.0 10.187968489549611 -8.005351525805953 24.88344540400739 0.8108131468373514 0.8828390558663615 0.018253459385501936 0.09978171620372658 533.1686917563181 2479104.9534841254 0.05335425989332301 0.02441999090562514 9.877532656501985e-09 8.005351525805953 0.07202590902901007 EGSIETLSNSSGSTSGS(ph)IPR ddPTM_A459_Selumetinib_30min_R1 1 EGSIETLSNSSGSTSGSIPR 20 0 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6;Q9H6U6-8;Q9H6U6-3 K7ESE9;Q9H6U6-8 BCAS3 Breast carcinoma-amplified sequence 3 1 EGSIETLSNSSGS(0.063)T(0.002)S(0.126)GS(0.808)IPR 163.15 3.9931e-07 4006000.0 1175.7 1328.2 1268.1 1464.4 1243.1 970.4 1161.4 1209.5 698.73 929.89 True False 1203.091522486036 1172.6937265365714 1095.8989851746949 1208.6700301925111 1130.6618244871302 960.6386570527036 1073.7946629514959 1177.4201309903067 1185.6937767799473 1049.2504393956344 1.1466199844329001 1.1176490211546064 1.0444589242258786 1.151936644304578 1.0775900414570123 0.9155475384942693 1.0233921498951184 1.1221535743825828 1.1300388660908294 1.0 10.035143352044852 -5.089928914503657 0.7800924055406471 1.0504597355463046 1.1731366104425565 0.18529487773860642 0.06554390472026152 3.7347107192892626 2.34038515196312 0.02971782800923629 0.368919427057344 8.129635714805136e-06 5.089928914503657 0.1226768748962519 EGSITQGT(ph)PLKYDTGASTTGSK ddPTM_A459_Selumetinib_30min_R1 2 EGSITQGTPLKYDTGASTTGSK 22 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 EGS(0.009)IT(0.014)QGT(0.792)PLKY(0.013)DT(0.057)GAS(0.084)T(0.023)T(0.006)GS(0.001)K;EGSIT(0.006)QGT(0.993)PLKYDTGASTTGSK 107.78 7.9334e-05 14960900.0 3697.7 4315.8 4276.0 4651.0 3879.3 3834.3 3871.0 3924.2000000000003 2136.82 3845.7 True False 3783.8492155282956 3810.5041296390145 3695.3426863867153 3838.79016008288 3528.417999946041 3795.7304232658503 3579.0073534400212 3820.117468401956 3626.027472842052 4339.333055290184 0.8719886598506917 0.878131289091428 0.8515923159854335 0.8846498093532874 0.8131244951673997 0.8747266860833337 0.8247828198107007 0.8803466845543833 0.8356186138838722 1.0 12.08325760572693 -10.734757076720928 5.127818295717506 1.000012963361794 0.8574187712172411 0.7615662508769345 0.02396738465456676 3.314297779029208e-06 5.094125956715519e-07 0.021653388233263484 0.005251240814299341 1.8418019281066963e-11 10.734757076720928 -0.14259419214455293 EGSITQGT(ph)PLKYDTGASTTGSK ddPTM_A459_Selumetinib_30min_R2 4 EGSITQGTPLKYDTGASTTGSK 22 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 EGS(0.019)IT(0.077)QGT(0.904)PLKYDTGASTTGSK;EGS(0.007)IT(0.034)QGT(0.951)PLKY(0.004)DTGAS(0.001)TTGSK;EGS(0.007)IT(0.034)QGT(0.937)PLKY(0.018)DT(0.001)GAS(0.002)T(0.001)TGSK;EGS(0.001)IT(0.033)QGT(0.924)PLKY(0.025)DT(0.005)GAS(0.008)T(0.002)T(0.001)GSK 87.208 0.00075923 42260400.0 61943.6 66061.1 69519.5 75978.4 64841.6 52984.9 61874.3 63792.2 49318.9 64955.7 True False 58501.0226918777 71127.77395008407 65046.69105710846 65630.0108499495 56695.61851674119 60283.08902596657 64751.577551599454 63977.82474063276 59184.0580852025 63080.260165823245 0.9274061733114638 1.1275757861985 1.031173474651435 1.0404207382376602 0.8987854261808952 0.9556569498524012 1.0264950934156376 1.0142289295010836 0.9382342103476026 1.0 15.944900989886639 -6.121465932469347 17.962870263443733 0.9743389951663219 1.0385183017253872 0.20169805062946577 0.05715535628665087 3.6503044950774353 523.4381548354945 0.0167144402510421 0.02157852158242575 7.560213628902293e-07 6.121465932469347 0.06417930655906523 EGSLS(ph)PVNSQK ddPTM_A459_Selumetinib_30min_R1 1 EGSLSPVNSQK 11 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 EGS(0.252)LS(0.548)PVNS(0.2)QK 113.52 0.0070489 3559900.0 1566.3 1819.9 2334.2 2461.6 2291.4 1800.0 2002.8 1761.3 1004.8 1755.0 True False 1602.7917425107416 1606.8252619514428 2017.2284608428156 2031.7277699548517 2084.1432745795273 1781.8936342692364 1851.72718353647 1714.5846024913005 1705.0722123116097 1980.2713451476388 0.8093798591986624 0.8114167110930175 1.0186626523611195 1.0259845323386108 1.0524533820511068 0.8998229654918264 0.9350876020469885 0.8658331630625448 0.8610295838949729 1.0 10.951482412682791 -5.243897549905086 23.485251834909395 0.9555643994006532 0.8103981908049777 0.4582669812352407 0.06389005711428147 377.9947064196116 506059.3169394447 0.018326252971273636 0.04818705141999056 5.7029878993328066e-06 5.243897549905086 -0.14516620859567553 EGSLSPVNS(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 EGSLSPVNSQK 11 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 EGSLS(0.189)PVNS(0.811)QK 110.08 0.0073423 0.0 1876.9 2007.4 2097.6 2426.8 2238.5 2025.1 1942.8 2075.0 1326.4 2013.2 True False 1920.6281181883478 1772.3726747850585 1812.757441292043 2003.0049366779463 2036.0280702392736 2004.729332643682 1796.253031842746 2019.964259450092 2250.803923576951 2271.613830228619 0.8454905902712577 0.7802262212000549 0.7980042281700689 0.8817541564608102 0.896291457265148 0.8825132625829817 0.7907387285373095 0.8892199160659272 0.9908391530396813 1.0 11.149501885100408 -8.167078963795495 3.1752974513619203 0.9996168671017008 0.8407706135501947 0.7186448106547194 0.03849904895570783 0.15006173922626762 2.7187292690162614 0.035659073913766805 0.011255594679365355 6.806455918766115e-09 8.167078963795495 -0.15884625355150617 EGSQGELT(ph)PANSQSR ddPTM_A459_Selumetinib_30min_R1 2 EGSQGELTPANSQSR 15 0 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 EGSQGELT(0.979)PANS(0.02)QS(0.001)R;EGSQGELT(1)PANSQSR 248.01 1.5515999999999993e-27 82496000.0 8000.8 8900.8 7598.7 8070.6 9275.400000000001 7085.2 8881.400000000001 7669.799999999999 4425.1 6080.4 True False 8187.203073153249 7858.690198130343 6566.83827667136 6661.221213924935 8436.441707704882 7013.92932084688 8211.468847543834 7466.371988978464 7509.071503483388 6860.878568111516 1.1933170062514034 1.1454349643581403 0.9571424725680444 0.9708991563974674 1.2296445162163898 1.0223077483759477 1.1968538381818459 1.0882530443959764 1.094476666353576 1.0 12.744177616847205 -6.238996004610047 24.997279603608074 1.1101011353030392 1.0644970424504823 0.03820104433810867 0.09262783675702148 2965.6375974200955 3303105.3286563577 0.027877132552106318 0.035961369559060236 5.767717695097107e-07 6.238996004610047 -0.045604092852556954 EGSQGELT(ph)PANSQSR ddPTM_A459_Selumetinib_30min_R2 1 EGSQGELTPANSQSR 15 0 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 EGSQGELT(0.912)PANS(0.088)QSR 147.49 0.00075532 50640000.0 24789.0 21261.0 26184.0 27142.0 32899.0 26063.0 22578.0 23513.0 26103.0 26268.0 True False 23411.326618229414 22891.65033511006 24499.349946983635 23445.212777438417 28765.933499208353 29652.941673642228 23627.921737458262 23581.418937213315 31324.329378758262 25509.574587539595 0.9177466499055186 0.8973748369089507 0.960398216869935 0.9190750201255988 1.127652419310017 1.1624239977771524 0.9262373880981754 0.9244144333450348 1.2279440126006234 1.0 14.638751219471235 -6.241292088102721 23.943218276229103 1.0559546270241214 0.924396915780425 0.34699246362669045 0.09242066586118972 608.7563411408978 723450.2179462664 0.02823862892684391 0.03640355492832028 5.737304655706195e-07 6.241292088102721 -0.1315577112436963 EGSQGELTPANS(ph)QSR ddPTM_A459_Selumetinib_30min_R2 1 EGSQGELTPANSQSR 15 0 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 EGSQGELT(0.323)PANS(0.65)QS(0.027)R 136.35 0.00040603 36956000.0 26322.0 25618.0 28336.0 30798.0 31303.0 25502.0 22797.0 24912.0 24523.0 28870.0 True False 24859.12861531464 27582.818225146937 26512.892609904084 26603.25927048664 27370.43728762938 29014.669015893192 23857.10567139852 24984.489795596397 29428.285229869703 28036.448086731692 0.8866718258465585 0.983819995308199 0.9456580422700323 0.9488812273291026 0.9762448225594773 1.034891043477952 0.8509318155279786 0.8911431904036503 1.0496438471389926 1.0 14.775015966692477 -4.748929709296645 24.679356702827537 0.9591060015779868 0.886671626780668 0.1355298302209138 0.057552852196177735 1157.7834739783573 2283938.47450535 0.014410897511714973 0.24583886337879285 1.7826672693785958e-05 4.748929709296645 -0.07243437479731873 EGSRPMMGDHR ddPTM_A459_Selumetinib_30min_R2 1 EGSRPMMGDHR 11 1 Q14151 Q14151 SAFB2 Scaffold attachment factor B2 0 96.229 0.016278 701770.0 4252.9 4097.6 3025.1 2852.4 4842.9 3042.3 3655.8 3535.5 3144.4 3971.0 False True 4016.5408437076076 4411.87274413936 2830.4683594798435 2463.898199335546 4234.491605924681 3461.349209750286 3825.801943830272 3545.787719666467 3773.367861876699 3856.34691210293 1.0415403321474832 1.1440549423323259 0.7339765907980363 0.6389202671582109 1.0980577480296092 0.8975720516447921 0.9920792996665331 0.919468035548931 0.978482472630819 1.0 11.913019125093602 EGSTQQLQT(ph)TSPKPLVQQPILPVVK ddPTM_A459_Selumetinib_30min_R2 1 EGSTQQLQTTSPKPLVQQPILPVVK 25 1 A0A087X0H9;Q5T8P6-3;Q5T8P6-5;Q5T8P6-4 A0A087X0H9 RBM26 RNA-binding protein 26 1 EGS(0.002)T(0.009)QQLQT(0.33)T(0.33)S(0.33)PKPLVQQPILPVVK 90.907 5.9877e-05 7423400.0 39678.0 39030.0 37312.0 38278.0 42242.0 26135.0 37892.0 36095.0 29837.0 35802.0 True False 37472.855603618824 42023.47549876981 34911.386542233966 33064.47036676694 36935.18231172859 29734.8590200913 39654.05308157357 36200.03047415106 35805.23371543539 34768.3032352327 1.0777878733422184 1.2086720256220336 1.0041153376405287 0.9509946500138905 1.0623234059434936 0.85522893708426 1.1405231027032077 1.0411790943386479 1.0298240173869604 1.0 15.085485041845189 -5.278262288112114 24.614399267802042 1.0108148070485055 1.143229946902359 0.3297463418247596 0.0756791316054365 643.9140486312168 942141.3292027639 0.019359355683196487 0.040480496774442036 5.269115419855299e-06 5.278262288112114 0.13241513985385356 EGSTQQLQTT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 EGSTQQLQTTSPK 13 0 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6;Q5T8P6-5;Q5T8P6-4 A0A087X0H9 RBM26 RNA-binding protein 26 1 EGSTQQLQT(0.008)T(0.963)S(0.029)PK;EGSTQQLQT(0.005)T(0.776)S(0.219)PK 214.61 4.0012e-06 29451000.0 8954.3 10107.8 11257.5 12054.9 8045.6 8256.6 7876.799999999999 8402.7 6216.2 7744.2 True False 9162.917767965224 8924.374077011265 9728.793333021158 9949.73801349884 7317.876900566049 8173.546100392989 7282.646634351935 8179.8331001837605 10548.437386715199 8738.24350489593 1.0485994997543102 1.021300684973021 1.1133580023914686 1.138642795651566 0.8374539913503134 0.9353763254381102 0.8334222581771219 0.9360958063941226 1.2071576376654003 1.0 13.093127593970303 -6.2472925094717615 24.792193136146974 0.9476706171330068 1.0785972579006007 0.25169585681218287 0.10225162625197061 1017.7779572761949 1783640.6352955496 0.031227347723130263 0.04010825292883956 5.658580394566665e-07 6.2472925094717615 0.13092664076759386 EGSTQQLQTT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 EGSTQQLQTTSPK 13 0 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6;Q5T8P6-5;Q5T8P6-4 A0A087X0H9 RBM26 RNA-binding protein 26 1 EGSTQQLQTT(0.5)S(0.5)PK;EGSTQQLQTT(0.996)S(0.004)PK 168.0 0.00068143 21994000.0 119542.0 120429.0 104490.0 109234.0 105654.0 80918.0 104307.0 96712.0 71027.0 102378.0 True False 112898.33420454164 129665.51705973208 97767.22716010983 94356.14076083952 92380.79996125579 92063.71999953108 109157.48218039931 96993.41590846662 85234.3846601946 99422.08113001085 1.1355458759398565 1.3041923442557286 0.9833552672495658 0.9490461242453095 0.9291778939977386 0.9259886632139848 1.0979199081304465 0.9755721747730431 0.8572983354546413 1.0 16.601278682030554 -5.307085748872742 8.510431654348386 0.9651514241343789 1.2196061536577234 0.6835149562211491 0.06943167229633573 0.1750980336771649 31.101392783199774 0.018168444532990262 0.03820745775842683 4.930764393212e-06 5.307085748872742 0.25445472952334447 EGSTQQLQTTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EGSTQQLQTTSPK 13 0 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6;Q5T8P6-5;Q5T8P6-4 A0A087X0H9 RBM26 RNA-binding protein 26 1 EGSTQQLQT(0.001)T(0.131)S(0.867)PK 104.9 0.010184 0.0 48379.0 41586.0 42672.0 38980.0 41832.0 31009.0 38806.0 46013.0 28702.0 38297.0 True False 45690.28885648156 44775.51247993444 39926.52997776068 33670.85675574939 36576.69017717509 35280.20827832451 40610.555892630204 46146.89021213779 34443.20200088569 37191.266102444184 1.2285220065008442 1.2039254688614063 1.0735458660585027 0.9053431163919575 0.9834752620796445 0.948615413660411 1.091937977609246 1.240799118938977 0.9261099610325476 1.0 15.182676242009316 -5.316650906623515 3.574585309276867 1.0213539130382943 1.2213065067414604 0.4305998256212893 0.09139946992704359 0.23401092966654702 6.017978248952193 0.026207917367551233 0.06497242321089601 4.8233535129694065e-06 5.316650906623515 0.1999525937031661 EGT(ph)GQQERESPRPLQLPGAEGPAIS(ph)DGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R1 2 EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 48 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 2 EGT(0.931)GQQERES(0.261)PRPLQLPGAEGPAIS(0.807)DGEEGGGEPGAGGGAAGAAGAGR;EGT(0.542)GQQERES(0.459)PRPLQLPGAEGPAIS(0.999)DGEEGGGEPGAGGGAAGAAGAGR 64.665 1.1628e-09 25648000.0 392.7 401.05999999999995 362.255 497.95000000000005 482.97 503.5 515.46 359.031 279.25 260.83 True False 401.8491459388165 354.1037087522644 313.06276072427977 410.99238017915894 439.2854487752793 498.43524714142217 476.5784372007733 349.5083315829524 473.8668543869596 294.3100711993498 1.3653937981164956 1.2031654482948821 1.0637174577428168 1.3964604694100828 1.4925940080308395 1.693571834325061 1.61930726753134 1.1875513812988556 1.6100939137281092 1.0 8.201193101474557 -5.93729020170499 7.023861520616723 1.4637251866354273 1.2109464044457192 0.179313333472496 0.20887530396754386 0.32169321496660236 29.30924852661884 0.057789555728444124 0.08603889174437547 1.1553399697181323e-06 5.93729020170499 -0.25277878218970806 EGT(ph)GQQERESPRPLQLPGAEGPAIS(ph)DGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R2 1 EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 48 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 2 EGT(0.538)GQQERES(0.468)PRPLQLPGAEGPAIS(0.994)DGEEGGGEPGAGGGAAGAAGAGR 49.077 0.00096425 3654000.0 4284.1 7388.2 8112.3 11203.0 12043.0 6013.6 4495.6 4167.8 7923.6 7316.3 True False 4046.006872611103 7954.851183192702 7590.363450004408 9677.132073747052 10530.050674213982 6841.918813974406 4704.654307862401 4179.927607983568 9508.541403881882 7105.059408969697 0.5694543338375567 1.1196037535098151 1.0683040088900657 1.3620057928763092 1.4820496308476248 0.9629643357150409 0.6621555200401373 0.5883029778338895 1.3382775366913804 1.0 12.794630997278297 -6.991284919908773 24.95121436256769 0.8556878846570161 1.1399590167788811 0.10864762676069262 0.2932615475309849 358.1305666042359 1025319.9509968691 0.10642849237928417 0.09372242632695364 1.0202699136363883e-07 6.991284919908773 0.28427113212186506 EGT(ph)GQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R2 1 EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 48 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 1 EGT(0.558)GQQERES(0.442)PRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 77.983 3.8495e-13 13108000.0 5937.8 6404.9 8177.2 7696.6 7455.7 5364.4 4219.1 4887.6 3603.1 4937.5 True False 5607.800846896712 6896.135235000534 7651.087854662186 6648.309802624443 6519.048311196314 6103.297406825241 4415.296509988046 4901.822106814264 4323.820679025544 4794.941545834349 1.1695243400346647 1.4382104910103892 1.5956582122068081 1.3865257248860992 1.3595678380813212 1.2728616915314719 0.9208238448337032 1.0222902740227915 0.9017462752558276 1.0 12.227297512408322 -7.098818753559483 2.589872159040139 0.9591702608627097 1.4043110945270416 0.7901259626254264 0.10424670349640824 0.1314954099318947 1.7234056507499462 0.04643383821852097 0.034797368077152765 7.96491685202851e-08 7.098818753559483 0.4451408336643319 EGT(ph)PPPPPPSR ddPTM_A459_Selumetinib_30min_R1 1 EGTPPPPPPSR 11 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 EGT(1)PPPPPPSR 133.88 0.0040609 39499000.0 3195.4 4450.1 5068.0 5335.4 2734.7 3694.2 3274.5 2933.2 3121.8 3416.8 True False 3269.846602833952 3929.080223204637 4379.79343653131 4403.672547862005 2487.3468678505005 3657.0397020652304 3027.5018286849267 2855.402007623621 5297.466592749191 3855.3795624503996 0.8481257292228072 1.019116317747816 1.1360213347574017 1.1422150469312342 0.6451626428889389 0.9485550366254708 0.7852668666326356 0.7406279878209414 1.3740454102999473 1.0 11.912657185245648 -4.7404875007976095 23.150176845136514 0.9615900093333485 0.8481247121784601 0.0297460541148723 0.2044910804901248 3032.3122945055225 3350015.9986028923 0.05129145083256814 1.9250707395814577 1.8176593684465355e-05 4.7404875007976095 -0.1134652971548884 EGTAPS(ph)ENGETK ddPTM_A459_Selumetinib_30min_R1 2 EGTAPSENGETK 12 0 Q15651;A0A087WZE9 Q15651 HMGN3 High mobility group nucleosome-binding domain-containing protein 3 1 EGT(0.005)APS(0.99)ENGET(0.004)K;EGT(0.003)APS(0.997)ENGETK 193.51 0.00015607 36096000.0 15000.2 18940.300000000003 9323.900000000001 9757.4 11739.3 11515.6 14560.8 14578.7 7799.2 14619.900000000001 True False 15349.675474691712 16722.76087089342 8057.765592516629 8053.453259082489 10677.482387741746 11399.763519328228 13462.467133032666 14192.02551770846 13234.67276896966 16496.50657488546 0.9304803659497398 1.0137152854139684 0.4884528464216719 0.48819143753400446 0.6472571837723092 0.6910410678515053 0.816079881635554 0.8603049047556905 0.8022712389978573 1.0 14.009872920341785 -8.225851465487716 0.9012411966414282 0.9764296350408647 0.7061735127858373 0.21132301624306926 0.16113437416215218 0.9556968984061035 1.6162674953675211 0.1709347186877283 0.06253137912497228 5.944954492319367e-09 8.225851465487716 -0.2702561222550274 EGTAPS(ph)ENGETK ddPTM_A459_Selumetinib_30min_R2 3 EGTAPSENGETK 12 0 Q15651;A0A087WZE9 Q15651 HMGN3 High mobility group nucleosome-binding domain-containing protein 3 1 EGT(0.001)APS(0.954)ENGET(0.045)K;EGT(0.393)APS(0.607)ENGETK;EGT(0.009)APS(0.991)ENGETK 161.04 0.00047841 80963000.0 224649.0 149877.0 190774.0 182519.0 172093.0 153903.0 183900.0 185543.0 149502.0 153394.0 True False 212163.90792119975 161372.083969488 178499.8085390258 157659.5973371634 150473.13880905983 175101.74125766655 192451.7143909367 186082.89941170285 179406.57743489728 148965.11665452467 1.4242522859445261 1.0832877360391506 1.1982658259047123 1.0583658837578915 1.0101233240936032 1.175454664757234 1.291924705011743 1.2491709709680596 1.2043529482876956 1.0 17.184615006993234 -7.001233737596597 24.998110918717057 1.2109211650534608 1.1424191388868457 0.0 0.12773720320288043 152.92372962110858 3098621.6804630277 0.044902541057482835 0.03906224446026492 9.971632454152107e-08 7.001233737596597 -0.06850202616661516 EGTAPS(ph)ENGETKAEEAQK ddPTM_A459_Selumetinib_30min_R1 1 EGTAPSENGETKAEEAQK 18 1 Q15651 Q15651 HMGN3 High mobility group nucleosome-binding domain-containing protein 3 1 EGT(0.005)APS(0.993)ENGET(0.002)KAEEAQK 74.742 0.008807899999999999 26007000.0 3755.9 5725.3 3409.9 4092.0 3579.7 4452.7 4690.4 4525.9 2785.3 4558.1 True False 3843.405162290808 5054.979214380239 2946.854309239959 3377.409016353288 3255.9167670473657 4407.909880728123 4336.599351737296 4405.8584298049 4726.450669736792 5143.176534653822 0.7472823723616364 0.9828515860423368 0.5729638656936178 0.6566776375644308 0.6330556116651974 0.8570403623185786 0.8431752872019946 0.8566414938548187 0.9189750026838076 1.0 12.328443958340527 -7.7706878122652165 0.9245375152124056 0.9749835740464695 0.7302986362260514 0.40574033745798166 0.10852221009945448 0.6447540287961939 1.0066341585647953 0.10390836286711623 0.04342558503278439 1.6955561941016823e-08 7.7706878122652165 -0.2446849378204181 EGTAPS(ph)ENGETKAEEAQK ddPTM_A459_Selumetinib_30min_R2 1 EGTAPSENGETKAEEAQK 18 1 Q15651 Q15651 HMGN3 High mobility group nucleosome-binding domain-containing protein 3 1 EGT(0.017)APS(0.968)ENGET(0.015)KAEEAQK 59.469 0.029021 30368000.0 97563.0 82441.0 73437.0 76789.0 74020.0 53774.0 70514.0 77064.0 47989.0 72819.0 True False 92140.83903563335 88763.95961040436 68712.14337215999 66330.20573158657 64720.945852804034 61180.88038822995 73793.04072084023 77288.24348136794 57588.14092469177 70716.52626351645 1.3029604804438757 1.2552081429966788 0.9716560894989754 0.9379731900915947 0.9152167007133435 0.8651567550171639 1.043504886620979 1.0929304303404666 0.8143519480877303 1.0 16.10975978796821 -5.24393793631525 4.009916765022582 0.9545461189354121 1.291806341547818 0.7420443441405274 0.0766857312982583 0.10384856180025125 3.9222633244560434 0.02060374544978947 0.05582460739853668 5.702457585204606e-06 5.24393793631525 0.33726022261240596 EGTETFADHR ddPTM_A459_Selumetinib_30min_R1 2 EGTETFADHR 10 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 ; 179.57 0.00015602 23823000.0 18795.3 18843.8 21077.8 20719.9 22311.0 17775.9 19571.5 18472.0 10165.8 14866.1 False True 19233.193920712594 16637.55913575504 18215.5505320678 17101.558425693656 20292.973989326987 17597.09058522585 18095.205997894947 17982.06255448777 17250.6201193445 16774.308743076534 1.146586378926103 0.9918476755486013 1.0859195935323491 1.019508981718975 1.2097651414519692 1.0490501191286892 1.078745257110139 1.0720002135354596 1.0283952908917668 1.0 14.033965694798537 -8.384713206355283 1.92250090523171 0.9999017964630496 1.0810937147410908 0.18751641973207778 0.058016590708474515 0.5579881167424448 4.20811269174399 0.05331487336891251 0.015253056611578929 4.123697444797969e-09 8.384713206355283 0.08119191827804129 EGTETFADHR ddPTM_A459_Selumetinib_30min_R2 2 EGTETFADHR 10 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 ; 161.67 0.00059233 31537000.0 218080.0 198049.0 215230.0 232510.0 238210.0 180197.0 181609.0 191498.0 163677.0 214473.0 False True 205959.98664340904 213238.72147209523 201382.33612470515 200841.73689787782 208283.9301755806 205017.50108449958 190054.1783514064 192055.22747579956 196416.9735174886 208280.60722222392 0.988858201395875 1.0238049730889314 0.9668799165245437 0.9642843833443926 1.0000159542138896 0.9843331254827639 0.9124909941741675 0.9220984614803203 0.9430401425127521 1.0 17.668168992323388 -7.175918690824389 7.4323872493382 0.9380173724536894 0.9883952112335286 0.37932994352130955 0.02686095793757838 0.25966753216348126 19.854300997507565 0.010181592976486352 0.007872708212037206 6.669316213280487e-08 7.175918690824389 0.050377838779839146 EGTGQQERES(ph)PRPLQLPGAEGPAIS(ph)DGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R2 1 EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 48 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 2 EGT(0.275)GQQERES(0.728)PRPLQLPGAEGPAIS(0.997)DGEEGGGEPGAGGGAAGAAGAGR 52.777 0.00063717 22892000.0 7890.3 7300.5 6625.4 8802.0 8744.6 5268.3 5620.6 4744.7 4819.5 8507.7 True False 7451.788713373495 7860.424875192651 6199.1289771900965 7603.152415703075 7646.025170284119 5993.960504134189 5881.9690370076105 4758.50629147263 5783.534668081273 8262.060595340743 0.9019285960666776 0.951387947895881 0.7503126981041505 0.9202489291824792 0.9254380407952917 0.7254800948221546 0.7119251873224766 0.5759466705141468 0.7000111656579722 1.0 13.012285925862779 -6.773634937149609 20.928996297664018 0.714247096152889 0.8872164798280835 0.2832486202553238 0.1125811112837188 34.74382241903291 59622.19450289796 0.038169445262540555 0.03403599654344878 1.6840890918065516e-07 6.773634937149609 0.17296938367519454 EGTGQQERES(ph)PRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R1 2 EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 48 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 1 EGT(0.393)GQQERES(0.545)PRPLQLPGAEGPAIS(0.062)DGEEGGGEPGAGGGAAGAAGAGR;EGT(0.107)GQQERES(0.892)PRPLQLPGAEGPAIS(0.001)DGEEGGGEPGAGGGAAGAAGAGR 66.789 3.5871e-10 26589000.0 1061.17 951.7199999999999 1361.31 1076.44 1141.13 1331.4 1280.77 889.11 751.42 1072.23 True False 1085.8931963226223 840.2921799573757 1176.4515791405754 888.4599612813618 1037.9149929828645 1318.0073248144786 1184.1604877461566 865.5279145636969 1275.1048584546072 1209.8611649046452 0.8975353766382002 0.6945360379623418 0.9723856036269228 0.7343486897948207 0.8578794188047746 1.0893872479313418 0.9787573335651994 0.7153944102602162 1.0539265954165113 1.0 10.240625788198779 -6.53993561447597 24.980169456916496 0.9529897582652211 0.82222290908761 0.24743577628204305 0.11847557491479471 374.7083745894696 548765.1983851984 0.03846202089860097 0.0384702151289007 2.884459101571025e-07 6.53993561447597 -0.13076684917761117 EGTGQQERES(ph)PRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R2 1 EGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 48 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 1 EGT(0.349)GQQERES(0.641)PRPLQLPGAEGPAIS(0.01)DGEEGGGEPGAGGGAAGAAGAGR 42.643 0.0031842 11278000.0 10828.0 9427.2 13889.0 13346.0 14345.0 12393.0 7142.7 3650.4 3943.7 11754.0 True False 10226.223107918357 10150.235926774347 12995.396861199806 11528.251776865858 12542.852854072884 14100.023257547029 7474.849702991542 3661.0220596437466 4732.550196184687 11414.631479440404 0.8958872764606932 0.8892302782666757 1.1384858884499789 1.0099539172710132 1.0988399298448301 1.2352587363808853 0.654848097063401 0.32073063998937146 0.41460385337089284 1.0 13.478596662557877 -7.422669426056507 5.267662431242862 0.518605520164315 1.0407015298874964 0.5543714335400032 0.1946911683527528 0.14986923516428338 6.273595184376467 0.08227583130291542 0.054199362239404844 3.7785969870774426e-08 7.422669426056507 0.5220960097231814 EGTGSTAT(ph)SSSSTAGAAGK ddPTM_A459_Selumetinib_30min_R2 1 EGTGSTATSSSSTAGAAGK 19 0 E5RGU4;A0A087WZK9;B3KS98;O15372;E5RHC7;E5RH59;E5RFW7;E5RFH0 E5RGU4 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 EGTGSTAT(0.374)S(0.037)S(0.284)S(0.284)S(0.016)T(0.004)AGAAGK 140.68 0.00026862 4058300.0 13230.0 15203.0 15074.0 14745.0 17404.0 13784.0 11984.0 9661.8 9208.8 15394.0 True False 12494.729563886209 16369.021214650207 14104.155251330267 12736.705563456242 15217.553926265897 15682.620881306231 12541.279745845493 9689.914238402907 11050.81731537023 14949.53522158461 0.8357938476806908 1.0949518478016693 0.943451086757951 0.851980036480772 1.0179282299221124 1.049037354597029 0.8389076690316096 0.6481749495738371 0.739208085841673 1.0 13.867813011535487 -7.481720046544415 6.566348337336596 0.7647953699467607 0.9663603448538951 0.3186993877370966 0.11239098628630204 0.20470777155886377 24.91303735480143 0.04697170992520047 0.030689158590511613 3.2982225258328624e-08 7.481720046544415 0.20156497490713443 EGTGSTATSSSS(ph)TAGAAGK ddPTM_A459_Selumetinib_30min_R1 2 EGTGSTATSSSSTAGAAGK 19 0 E5RGU4;A0A087WZK9;B3KS98;O15372;E5RHC7;E5RH59;E5RFW7;E5RFH0 E5RGU4 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 EGTGSTATSSS(0.011)S(0.986)T(0.002)AGAAGK;EGTGSTATSSS(0.005)S(0.992)T(0.003)AGAAGK 381.08 1.9087999999999986e-266 17145300.0 3986.2999999999997 5213.700000000001 4786.200000000001 4808.0 4279.0 4133.8 4117.5 3963.8 2068.1 3401.0 True False 4079.173034010451 4603.27758021663 4136.260328714713 3968.373057337881 3891.965205518809 4092.2177251900953 3806.9136599817302 3858.6671477630275 3509.4146519522687 3837.551478545368 1.0629624271663634 1.199535069679772 1.0778383956122386 1.034089856389914 1.0141792826174847 1.06636164962698 0.9920163107296607 1.005502380706998 0.9144931791983465 1.0 11.90597038819871 -6.078890787163212 0.5535322719621286 0.9714929643052053 1.1514007122207823 0.5674509694728099 0.046292060056408346 0.9004920565176501 0.5184906054381054 0.03385005845119901 0.08871228341530712 8.338908583318131e-07 6.078890787163212 0.17990774791557707 EGTGSTATSSSS(ph)TAGAAGK ddPTM_A459_Selumetinib_30min_R2 2 EGTGSTATSSSSTAGAAGK 19 0 E5RGU4;A0A087WZK9;B3KS98;O15372;E5RHC7;E5RH59;E5RFW7;E5RFH0 E5RGU4 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 EGTGST(0.001)AT(0.002)SSS(0.022)S(0.972)T(0.003)AGAAGK;EGTGSTATSSS(0.002)S(0.995)T(0.003)AGAAGK 333.03 8.269699999999993e-155 10482300.0 55644.0 50692.0 56654.0 60697.0 56203.0 50895.0 41303.0 39076.0 34905.0 47279.0 True False 52551.529240580785 54579.91339952957 53008.94332021123 52429.963891834785 49142.27667880503 57905.32427118985 43223.67134034183 39189.70469061997 41886.97532718678 45913.932424405524 1.1445660710309153 1.188744037322267 1.1545284954079507 1.141918392160321 1.070312954781531 1.261171091509694 0.9414064328187737 0.8535471178632633 0.9122933522662455 1.0 15.486644380456827 -7.363052059974963 6.207743754329403 0.9104102553717336 1.1558753549842455 0.8054472898551034 0.05606840641153925 0.09513615911422504 4.905599160474594 0.022829809950191324 0.015259481957835108 4.3345891545962125e-08 7.363052059974963 0.24546509961251195 EGTPGS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 EGTPGSPGR 9 0 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 EGT(0.002)PGS(0.998)PGR 95.483 0.022335 6796500.0 3634.9 4774.3 4691.4 4564.6 4832.6 4663.0 4289.6 4092.3 3026.7 3484.8 True False 3719.5860977158227 4215.322736488147 4054.3336480155854 3767.4782981540106 4395.49218326483 4616.094453665246 3966.0320184232273 3983.7589103361984 5136.088838578372 3932.108024826494 0.9459521646483634 1.0720261777839 1.0310839942385572 0.9581319420440522 1.1178462431633684 1.173949043240981 1.008627431744638 1.0131356730749999 1.3061922017783334 1.0 11.941087241320414 -6.2758091019583 24.193319227058495 1.1027482023456592 1.0089066422385722 0.2235660432481119 0.09227705109019355 869.3841509298574 1463719.262853502 0.02823633817925696 0.03218118062403365 5.298963133936908e-07 6.2758091019583 -0.093841560107087 EGTQASEGYFSQS(ph)QEEEFAQSEELCAK ddPTM_A459_Selumetinib_30min_R1 2 EGTQASEGYFSQSQEEEFAQSEELCAK 27 0 Q16643-3;Q16643;Q16643-2 Q16643-3 DBN1 Drebrin 1 EGTQASEGY(0.001)FS(0.03)QS(0.969)QEEEFAQSEELCAK;EGTQASEGYFS(0.007)QS(0.992)QEEEFAQSEELCAK 132.94 3.5888e-12 13680900.0 2747.1 3961.1000000000004 3688.0 3820.6000000000004 3938.2 3579.1 3780.0 3009.3999999999996 1805.6399999999999 2931.5 True False 2811.102085073905 3497.3325705345715 3187.189856733915 3153.4039315443238 3581.9905053456823 3543.097503562792 3494.871556704542 2929.5809360911358 3064.0392012722286 3307.7865802280935 0.8498438508327406 1.0573029685287034 0.9635415645570874 0.9533275061920337 1.0828964984490266 1.0711384841879588 1.0565589622966387 0.8856620174960387 0.9263110321527888 1.0 11.691650438887342 -4.747504773767573 24.985523298602548 1.0001044388830298 0.849843471342944 0.3331033473625916 0.06358193531106926 946.8965364222599 1697740.432992477 0.017220076565407555 0.3484072984096342 1.788525869512543e-05 4.747504773767573 -0.15026096754008578 EGTSQLAS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 EGTSQLASPLK 11 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 EGTS(0.004)QLAS(0.996)PLK 117.08 0.0057020000000000005 5379300.0 38399.0 37583.0 39710.0 44057.0 45541.0 28918.0 34572.0 37442.0 25005.0 37978.0 True False 36264.93730337615 40465.495251608125 37155.10183297894 38056.36059743588 39819.7324382944 32901.19200853262 36179.666503118366 37550.95002114323 30006.69869807494 36881.47646130571 0.9832832300361835 1.0971766624924193 1.0074190460341332 1.0318556698065708 1.0796675257855082 0.892079037102839 0.9809712076217 1.0181520270898021 0.8135980870927588 1.0 15.170608791302786 -6.756472288417498 24.999998641314765 0.9445952681167827 1.040814322975993 0.38531335635984165 0.06238055660593271 133.89417031016455 673905.7483252245 0.0200696529486498 0.019474026586584234 1.7519742210980588e-07 6.756472288417498 0.09621905485921023 EGVHGGLINK ddPTM_A459_Selumetinib_30min_R1 1 EGVHGGLINK 10 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 130.41 0.0039106 26532000.0 8115.2 10253.0 7282.8 7207.0 8505.8 7832.2 8917.3 7219.5 4479.1 7373.9 False True 8304.268370569594 9052.573993509614 6293.835761556869 5948.432742145196 7736.451891820959 7753.415179068621 8244.66088164058 7028.015407759011 7600.705559479432 8320.411892868475 0.9980597688543861 1.0879958961248881 0.7564331961680156 0.7149204653250003 0.9298159744293386 0.93185473013832 0.9908957618681329 0.8446715737453825 0.9135011171735486 1.0 13.02243923383254 -8.572137512973885 19.648920963921576 1.0000000025183264 0.9041884738956653 0.06372046147462962 0.1061760779831422 6337.947006362941 2528155.4859730685 0.11091211544616864 0.028637293255828342 2.67832013977885e-09 8.572137512973885 -0.09581152862266118 EGVHGGLINK ddPTM_A459_Selumetinib_30min_R2 3 EGVHGGLINK 10 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 ;; 142.36 0.0016969 86092000.0 798238.0 629030.0 760618.0 814798.0 829847.0 669451.0 723244.0 805929.0 707252.0 700893.0 False True 753875.1275598949 677274.5783497617 711680.6659782631 703821.1067950524 725594.2009336924 761661.7985788838 756876.2790807987 808274.119961272 848722.1622719816 680656.3979512852 1.1075707652627544 0.9950315318981757 1.0455799256722749 1.0340328966472523 1.0660212746367563 1.1190107091792827 1.1119799672183035 1.1874921361117072 1.2469171887997517 1.0 19.37656716977979 -6.904714980610533 1.5147696570264213 1.1556273750303483 1.0413241823931165 0.28878645432695904 0.06452588350296808 0.42172037437388693 1.9908228131543197 0.029807109808367326 0.02398731127075706 1.2453316316280275e-07 6.904714980610533 -0.11430319263723177 EGVHGGLINKK ddPTM_A459_Selumetinib_30min_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 80.24 0.029799000000000006 75915000.0 6127.6 6123.2 8125.2 8550.9 8226.8 7127.3 6627.4 6315.8 4239.1 6126.5 False True 6270.361157765954 5406.292897401548 7021.84246852885 7057.645835272562 7482.687392559506 7055.605833070624 6127.489882249651 6148.284467390308 7193.443088385899 6912.895952163538 0.9070527317575945 0.7820590581447321 1.0157598952912368 1.0209391091824147 1.0824244201473392 1.0206440082267434 0.8863853766426099 0.8893934625858316 1.0405831562001968 1.0 12.755074496083639 -5.27074308866361 24.976183245136255 0.9917205270972721 0.8445558929564514 0.4590333037384805 0.06506114428344538 559.7796551714717 1502752.9205763799 0.01857802418953367 0.03952777396380094 5.36113707266159e-06 5.27074308866361 -0.1471646341408207 EGVHGGLINKK ddPTM_A459_Selumetinib_30min_R2 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 90.149 0.019052 62211000.0 1011400.0 936970.0 1052300.0 1079500.0 1112500.0 748710.0 800840.0 851830.0 640170.0 930590.0 False True 955190.4369549883 1008832.5861666013 984596.1636576108 932470.2377586322 972737.8041238113 851838.0063873181 838080.6468343553 854308.6842719525 768221.8878442963 903721.4487368101 1.0569522702931524 1.1163092206970542 1.0894907551810842 1.0318115599248043 1.0763690576155627 0.9425891214355786 0.9273661126509665 0.9453230145926877 0.8500649054175816 1.0 19.785518638169748 -6.786362653960078 4.774944266705954 0.9274694367017015 1.0757823686673484 0.7594941321025208 0.03970063950967337 0.09096355684513668 5.066056428618834 0.013762035713862421 0.0125843124199958 1.635450282049686e-07 6.786362653960078 0.148312931965647 EGVNQPAAVVMEDS(ph)SPHEALR ddPTM_A459_Selumetinib_30min_R2 3 EGVNQPAAVVMEDSSPHEALR 21 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 EGVNQPAAVVMEDS(0.564)S(0.436)PHEALR;EGVNQPAAVVMEDS(0.862)S(0.138)PHEALR;EGVNQPAAVVMEDS(0.86)S(0.14)PHEALR 188.96 9.6197e-17 28692500.0 129306.6 128479.2 149199.1 173574.7 166150.0 133409.9 117279.5 130909.0 115710.7 148547.3 True False 122120.25682733253 138333.14151425913 139599.79234169764 149933.52642694162 145276.7516001539 151785.90275050607 122733.22913492043 131289.9235168485 138856.0732270881 144258.3534767635 0.8465385461854944 0.9589263857537458 0.9677068188927012 1.0393403419171303 1.0070595435123584 1.0521810286359263 0.8507876748689618 0.9101027451973248 0.9625513523516989 1.0 17.138295336950996 -4.754104515868668 3.780673214752563 0.9720718753973956 0.8296572157130716 0.312290216890002 0.05622154394259104 0.40254027458725483 9.886408689327427 0.015517638228896825 0.16713926730386722 1.76155206612288e-05 4.754104515868668 -0.14241465968432399 EGVQGPLNVS(ph)LSEEGK ddPTM_A459_Selumetinib_30min_R1 2 EGVQGPLNVSLSEEGK 16 0 P12270 P12270 TPR Nucleoprotein TPR 1 EGVQGPLNVS(0.916)LS(0.084)EEGK;EGVQGPLNVS(0.999)LS(0.001)EEGK 187.31 8.565399999999998e-07 7948300.0 2181.93 2903.0299999999997 2281.75 2613.75 2514.8999999999996 1905.15 2749.5 2385.55 1181.8400000000001 1938.4099999999999 True False 2232.764723703289 2563.141898017968 1971.9008827555886 2157.307628664078 2287.427739041658 1885.9859207377976 2542.1030013648515 2322.2774646415264 2005.4961618216084 2187.2238052123284 1.0208213345074395 1.1718699713809793 0.9015542342106884 0.986322306625889 1.045813297016307 0.8622738634443092 1.1622509755548645 1.0617466118955703 0.9169140154026997 1.0 11.094885134746349 -5.2541593140179454 24.956156055695214 0.9974654628606203 1.0963456396247448 0.17817364290824145 0.08895311241181046 984.545556362228 3375014.159281306 0.022492991676424896 0.05699817481328598 5.569813916936483e-06 5.2541593140179454 0.09888017676412453 EGVQGPLNVS(ph)LSEEGK ddPTM_A459_Selumetinib_30min_R2 2 EGVQGPLNVSLSEEGK 16 0 P12270 P12270 TPR Nucleoprotein TPR 1 EGVQGPLNVS(0.97)LS(0.03)EEGK;EGVQGPLNVS(0.999)LS(0.001)EEGK 243.37 8.948e-22 26420000.0 114874.0 106251.0 115903.0 123037.0 109891.0 92420.0 113594.0 107621.0 94666.0 108734.0 True False 108489.76295705688 114400.11004918753 108445.92716564483 106279.14834933632 96085.51014199523 105150.0160947709 118876.34608224074 107934.15929238431 113601.8451890409 105594.56689513961 1.0274180400284452 1.0833901157319223 1.0270029070088118 1.0064831124775249 0.9099474808908746 0.995790022030109 1.125780895529318 1.0221563709766246 1.0758304004585093 1.0 16.688176080770624 EGVQGPLNVSLS(ph)EEGK ddPTM_A459_Selumetinib_30min_R2 1 EGVQGPLNVSLSEEGK 16 0 P12270 P12270 TPR Nucleoprotein TPR 1 EGVQGPLNVS(0.272)LS(0.728)EEGK 242.09 1.2885e-21 16468000.0 96997.0 88270.0 98562.0 91673.0 99586.0 77618.0 99930.0 95494.0 67693.0 80029.0 True False 91606.29504975592 95040.02516721506 92220.62822619152 79186.97925525422 87075.11636986425 88309.17495394849 104576.94300753849 95771.87173011733 81233.4915004513 77718.35482968662 1.1786957566266498 1.2228774705214418 1.1866003652327104 1.0188967513373897 1.1203932013316829 1.1362718002390912 1.3455887381650093 1.2322941207388334 1.0452291698462715 1.0 16.245967741304234 -8.407920736903758 4.83257182662776 1.0024890436536311 1.178080981543722 0.3884949251589538 0.07982949473046877 0.24452509719658205 8.028081881036995 0.08499457915232751 0.022170847293972867 3.909122346834404e-09 8.407920736903758 0.17559193789009098 EGVSSTT(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 EGVSSTTPAK 10 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 EGVS(0.001)S(0.016)T(0.097)T(0.886)PAK;EGVS(0.028)S(0.069)T(0.069)T(0.835)PAK 117.25 0.0094263 4298100.0 10243.0 13959.3 8057.3 8681.4 9388.7 9720.1 11178.4 10451.1 5769.6 10643.5 True False 10481.641970591532 12324.938666497485 6963.162915580848 7165.356460060953 8539.493742709614 9622.324619144672 10335.204288218532 10173.902878042823 9790.589805088635 12009.696901469459 0.872764904608795 1.0262489359735176 0.5797950583356407 0.5966309157381173 0.7110498968266847 0.8012129446803377 0.860571617503016 0.8471406865229034 0.8152237217486061 1.0 13.55191212057927 -7.122906855521278 3.1187139675505673 0.8689402896042746 0.753623466750167 0.1661182939517999 0.12886555884352868 0.6011811193052694 11.077310247947555 0.0590945576075847 0.044506189202679555 7.535171555559127e-08 7.122906855521278 -0.1153168228541076 EGVSSTT(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 EGVSSTTPAK 10 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 EGVS(0.001)S(0.033)T(0.033)T(0.932)PAK;EGVS(0.007)S(0.068)T(0.068)T(0.857)PAK 113.38 0.017922999999999998 11699800.0 110972.0 92068.0 103988.0 118600.0 114833.0 141669.0 131677.0 131177.0 123858.0 113709.0 True False 104804.62049611342 99129.3195547204 97297.52529357381 102446.47540358845 100406.65191995473 161182.61880686125 137800.2414130254 131558.7033524786 148633.06088167042 110425.92571853712 0.9490943346334106 0.8976996924380741 0.881111248653454 0.9277393396249413 0.9092670155727709 1.4596447143915918 1.247897543229678 1.1913751457950779 1.3459978706496774 1.0 16.75271940121329 -6.739183262365584 24.864678252157777 1.260876128900403 0.9111823469708024 0.6966039884529722 0.11072988386227572 115.09736730725606 128587.21963571406 0.03456878594944149 0.034542349488998765 1.8231262222972397e-07 6.739183262365584 -0.34969378192960054 EGVTPWAS(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 EGVTPWASFK 10 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EGVT(0.001)PWAS(0.999)FK 117.86 0.005892199999999999 72030000.0 4190.0 4795.6 5064.1 5158.8 3947.5 4034.6 4675.1 4402.1 2592.0 3420.1 True False 4287.618847679246 4234.128922586046 4376.423035110142 4257.912422669435 3590.44932198773 3994.0155871237016 4322.453443055399 4285.342007963979 4398.434687810203 3859.1031495951247 1.1110402291602592 1.0971795151498522 1.1340518419595216 1.1033424755998427 0.9303843879799947 1.0349595313467408 1.1200668330176367 1.1104502372302676 1.1397556679125465 1.0 11.914049890712938 -8.422632158528288 0.006181296054302412 8.989943336588916e-08 2.1348800626963116 0.08011197552114557 0.06186555358258843 13634.343183598627 61.4946477324207 10689.176727870235 10543.617500074495 3.778921248650736e-09 8.422632158528288 2.1348799727968784 EGVTPWAS(ph)FK ddPTM_A459_Selumetinib_30min_R2 2 EGVTPWASFK 10 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EGVTPWAS(1)FK;EGVTPWAS(1)FK 113.77 0.007427 28171000.0 164918.0 149342.0 147866.0 170433.0 172701.0 122713.0 153993.0 148588.0 134291.0 142500.0 True False 155752.51777906183 160796.05118978448 138352.46254432786 147219.73138667585 151004.75641347095 139615.60187229616 161153.97963134077 149020.3664799325 161152.9524040463 138385.6547405358 1.1254961222034738 1.1619416152004103 0.9997601471317951 1.0638366502850558 1.0911879319904592 1.0088878224702296 1.1645280714499933 1.076848368129891 1.1645206485180686 1.0 17.078334873283325 -10.249458119836362 15.266023229403602 1.0000000019370854 1.0922944923173858 0.19696722761027163 0.05740758761874274 0.0 0.0 0.05544563133293046 0.013447540850866382 5.630434105391717e-11 10.249458119836362 0.09229449038030046 EGVTPWAS(ph)FKK ddPTM_A459_Selumetinib_30min_R1 2 EGVTPWASFKK 11 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EGVT(0.002)PWAS(0.998)FKK;EGVTPWAS(1)FKK 117.27 0.010142 484781000.0 12612.5 15270.0 17680.2 17830.8 14396.5 15237.9 15980.8 14761.0 8857.1 11362.0 True False 12906.34671034713 13482.181301169587 15279.325950386923 14716.98550556994 13094.339116908512 15084.620560906209 14775.355389784114 14369.490329514618 15029.851803010712 12820.423375252121 1.0067020668959241 1.0516174783427892 1.1917957389676646 1.147932878252589 1.021365576911067 1.176608612631684 1.1524857609855297 1.120828065417304 1.1723366197112925 1.0 13.646156285132559 -5.051370465387039 6.176940742308689 1.127438445031223 1.0166198027599913 0.2840946046049182 0.06105454266296819 0.21021182792691964 19.07866696275494 0.01496242878488771 0.04269610122370081 8.884429277624192e-06 5.051370465387039 -0.11081864227123162 EGVTPWAS(ph)FKK ddPTM_A459_Selumetinib_30min_R2 2 EGVTPWASFKK 11 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EGVT(0.015)PWAS(0.985)FKK;EGVT(0.129)PWAS(0.871)FKK 70.373 0.034115 338480000.0 692440.0 739700.0 739450.0 761950.0 671830.0 518310.0 646830.0 629090.0 478140.0 722370.0 True False 653956.9568569431 796432.6114896256 691874.5920522868 658171.0955629352 587428.7091635956 589702.4977502786 676908.8766693291 630920.5477485447 573781.3603478337 701513.3011573399 0.9322089200276894 1.135306501210583 0.986260119246276 0.9382161314362825 0.8373735867794234 0.8406148490376468 0.9649266457992757 0.8993707556330963 0.8179194313225749 1.0 19.420110932995897 -5.765218598330147 2.7744355748837477 0.8898144028622074 1.0371572212813056 0.3815141166338998 0.07091276039792081 0.23943443449842644 3.764585078656496 0.019986874773491765 0.03549270553593253 1.7170439105733181e-06 5.765218598330147 0.14734281841909824 EGWPS(ph)SAYGVTK ddPTM_A459_Selumetinib_30min_R2 1 EGWPSSAYGVTK 12 0 P16152 P16152 CBR1 Carbonyl reductase [NADPH] 1 1 EGWPS(0.819)S(0.156)AYGVT(0.024)K 87.824 0.02799 2587800.0 15152.0 13856.0 19304.0 18503.0 14662.0 13078.0 13737.0 14594.0 11724.0 13306.0 True False 14309.912498261814 14918.710645937854 18062.001656606022 15982.859480544666 12820.028480056919 14879.375789736136 14375.79771934911 14636.466123833243 14069.12759593003 12921.821206860122 1.1074222641824483 1.1545362226508438 1.3977907113446986 1.2368890750523198 0.9921224164014 1.1514921582289621 1.1125210207766285 1.1326937503254437 1.0887882884852802 1.0 13.657521797951269 -6.232218728961598 24.16909713854425 1.0914779903591834 1.2315887415692783 0.40206970035489087 0.08543760001349278 525.2877265722072 434477.58901857317 0.02616518440159473 0.03377166763644529 5.85843035015441e-07 6.232218728961598 0.14011075121009497 EGYAWAEDKEHCEEYGR ddPTM_A459_Selumetinib_30min_R1 1 EGYAWAEDKEHCEEYGR 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 102.29 0.0028998 16446000.0 5933.3 6781.5 7583.1 7582.9 6693.2 6331.2 6565.4 5376.1 3712.4 4890.6 False True 6071.534345807938 5987.51882736618 6553.356670986699 6258.688863662105 6087.801241780434 6267.513876269658 6070.166592166138 5233.508363966094 6299.671657031865 5518.356148478088 1.100243293916869 1.0850185573864208 1.1875559486667158 1.1341581977067925 1.1031910732074433 1.1357574081183908 1.0999954386489235 0.9483817686195278 1.1415848284401247 1.0 12.430022854267794 -7.540832078094039 24.93661445876053 1.0318276536193367 1.1243104262614432 0.39936165527000833 0.05178799636591919 230.92614796302888 320745.22085344436 0.02299940381274098 0.013281376667954209 2.878511188831824e-08 7.540832078094039 0.09248277264210647 EGYAWAEDKEHCEEYGR ddPTM_A459_Selumetinib_30min_R2 2 EGYAWAEDKEHCEEYGR 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 ; 148.57 0.00026927 28582000.0 125293.0 108103.0 119085.0 111910.0 104250.0 101795.0 97053.0 105205.0 82794.0 97024.0 False True 118329.71664761877 116394.15249406906 111423.20074994468 96667.66494448202 91153.18299317521 115816.33724699433 101566.15680687121 105511.12913237468 99355.11345764506 94222.66502137376 1.2558519398785473 1.2353094923356907 1.1825519977031969 1.0259491696881384 0.9674231032681759 1.2291770480141078 1.0779376361709958 1.1198062494670493 1.054471484489502 1.0 16.523786517740227 -5.573792978375829 4.308701061657048 1.0761417533992788 1.2393036041038936 0.5346997187964779 0.06818136436421852 0.16866477862159765 6.598106869896419 0.019306377340292065 0.035870266985339856 2.6681302188339027e-06 5.573792978375829 0.16316185070461486 EHAASLCR ddPTM_A459_Selumetinib_30min_R2 2 EHAASLCR 8 0 H3BPG2;H3BQF2;A0A0B4J287;H3BM91;Q9H0A8-2;Q9H0A8 H3BPG2 COMMD4 COMM domain-containing protein 4 0 ; 116.25 0.013268 831030.0 2145.8599999999997 1566.5 3315.6000000000004 4296.9 4837.0 2935.1 3970.7200000000003 6706.6 2745.06 4742.299999999999 False True 2026.60169175819 1686.6455129086066 3102.2779057523276 3711.6548074340544 4229.332816671349 3339.3833828149973 4155.366347832413 6726.115095662601 3294.148703384826 4605.377477024859 0.44005115799267863 0.3662339344218542 0.6736207664255232 0.8059393233129366 0.9183466149670666 0.7251052491298254 0.9022857232794825 1.4604915947102275 0.715283105417212 1.0 12.169103695465765 -5.451585719579786 0.5563082139053844 1.0407652160132532 0.16676409669365533 0.5536525758402024 0.19446209637370288 1.5406891884377674 0.6073593288150411 0.1229299779584638 0.7979119166183575 3.535202375818697e-06 5.451585719579786 -0.8740011193195979 EHALLAYTLGVK ddPTM_A459_Selumetinib_30min_R1 2 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y660;A0A2R8Y488 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 ; 128.28 0.0034748000000000005 39390000.0 18045.8 23023.0 20507.1 22681.0 19070.1 17886.4 16911.7 16678.0 11544.0 14019.6 False True 18466.232028985723 20327.456456897682 17722.348457437107 18720.189125099918 17345.212822099616 17706.479055551816 15636.03685331221 16235.645262221042 19589.324859599146 15819.15222246829 1.1673338602025543 1.2849902555477117 1.1203096226778617 1.1833876342950427 1.0964691772460364 1.11930644616991 0.9884244511601578 1.0263284045753853 1.238329626272639 1.0 13.949384664744866 -6.081333104387628 1.0333353385730455 1.068254284070797 1.2179035116762302 0.34887314537712466 0.0758942421555518 0.6095942383499582 1.3396898579296246 0.031824391081404155 0.060449549481833696 8.292145150165115e-07 6.081333104387628 0.1496492276054333 EHALLAYTLGVK ddPTM_A459_Selumetinib_30min_R2 2 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y660;A0A2R8Y488 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 ; 98.105 0.021904 3881400.0 78829.0 88586.0 97054.0 83937.0 103268.0 71320.0 81356.0 80053.0 66997.0 88472.0 False True 74447.99975748952 95380.26135111501 90809.65130440546 72504.63580059874 90294.55061236654 81143.68262150025 85139.21520385562 80285.94097651241 80398.2720525866 85917.58348213801 0.8665048147329123 1.1101366854777086 1.0569390760773025 0.8438858829831059 1.0509437876722696 0.9444362764040001 0.9909405240844069 0.9344529690270398 0.9357603972800416 1.0 16.39066579620421 EHAPLAS(ph)PVENK ddPTM_A459_Selumetinib_30min_R1 3 EHAPLASPVENK 12 0 Q9ULJ3 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 EHAPLAS(1)PVENK;EHAPLAS(1)PVENK;EHAPLAS(1)PVENK 124.16 0.0020634 25288500.0 17563.9 30523.9 15592.3 19424.0 17611.8 20246.1 19640.7 17984.0 11829.3 18883.5 True False 17973.104696599876 26950.147597823867 13474.951302373152 16031.963033637881 16018.815799615839 20042.442615987995 18159.18618618172 17507.00589973517 20073.45812211159 21307.381165866358 0.8435154257902012 1.2648268404282839 0.6324076711951598 0.7524135842334532 0.7517965570202214 0.9406337860091062 0.8522486196131915 0.8216404335874344 0.9420894086350008 1.0 14.379065665716006 -10.252026923581036 15.254528038505828 0.9999999787616382 0.8653142491656961 0.05912564638758777 0.15925117597576385 0.0 0.0 0.15614555763153246 0.03787086041681048 5.597229010495885e-11 10.252026923581036 -0.13468572959594205 EHAPLAS(ph)PVENK ddPTM_A459_Selumetinib_30min_R2 3 EHAPLASPVENK 12 0 Q9ULJ3 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 EHAPLAS(1)PVENK;EHAPLAS(1)PVENK;EHAPLAS(1)PVENK 115.1 0.0035317 42637700.0 438743.0 379320.0 404857.0 418283.0 448155.0 368089.0 443514.0 461309.0 365793.0 432031.0 True False 414359.4204873864 408412.6242939634 378808.9413949734 361312.1338215785 391853.76234346675 418789.91857074376 464138.2798063188 462651.3328161843 438961.821110375 419557.1424786559 0.9876114086377783 0.9734374247120356 0.9028780660413724 0.8611750277614676 0.9339699475224676 0.9981713482378597 1.1062576054939426 1.1027135185518162 1.0462503832423882 1.0 18.67850778940784 -6.977880517784352 3.2545221234972246 1.0717043392747931 0.9289044062485238 0.6694134091365495 0.04346268458119942 0.14822019707025844 3.266140366674194 0.01813027792908485 0.01497693746023579 1.0522513272521179e-07 6.977880517784352 -0.14279993302626937 EHASIDAQSGAGVPNPSTS(ph)ASPK ddPTM_A459_Selumetinib_30min_R1 2 EHASIDAQSGAGVPNPSTSASPK 23 0 Q8IXJ6-5;Q8IXJ6-2;Q8IXJ6-3;Q8IXJ6 Q8IXJ6-5 SIRT2 NAD-dependent protein deacetylase sirtuin-2 1 EHASIDAQSGAGVPNPS(0.017)T(0.059)S(0.764)AS(0.161)PK;EHASIDAQSGAGVPNPS(0.048)T(0.164)S(0.57)AS(0.218)PK 166.57 2.4046e-12 18361200.0 4522.6 5173.0 5255.700000000001 6040.1 7485.5 5194.4 6017.1 4425.3 1699.1799999999998 3433.1 True False 4627.967780552303 4567.3427551375435 4542.004807493611 4985.309921719329 6808.437846672366 5142.149052137845 5563.225302604999 4307.926668599756 2883.3843568029874 3873.771826225848 1.194692921565609 1.179042793438722 1.1725018951151833 1.286939485688922 1.7575732779557423 1.3274269324086017 1.4361262232693652 1.1120754814299163 0.7443351044277229 1.0 11.919523263160015 -8.00112490334036 4.418888614361608 0.8798789007866938 1.3364840730140517 0.5398362751937071 0.17195755393070908 0.1618705969179172 7.861434162644196 0.12182153566471053 0.04916093100313392 9.974131659739003e-09 8.00112490334036 0.45660517222735786 EHASIDAQSGAGVPNPSTS(ph)ASPK ddPTM_A459_Selumetinib_30min_R2 1 EHASIDAQSGAGVPNPSTSASPK 23 0 Q8IXJ6-5;Q8IXJ6-2;Q8IXJ6-3;Q8IXJ6 Q8IXJ6-5 SIRT2 NAD-dependent protein deacetylase sirtuin-2 1 EHASIDAQSGAGVPNPS(0.037)T(0.157)S(0.67)AS(0.136)PK 188.69 2.4217e-22 11502000.0 19102.0 21234.0 37808.0 47939.0 54367.0 33695.0 27327.0 29892.0 28189.0 48655.0 True False 18040.38731136466 22862.57952192874 35375.47444223794 41409.62550061234 47536.93141285327 38336.18039724414 28597.759647423245 29978.980771112998 33827.58766646806 47250.203729128196 0.38180549262358743 0.4838620305849541 0.7486840616610955 0.8763904117324401 1.0060682846018782 0.8113442349796928 0.605240980787426 0.6344730478406793 0.7159246944286606 1.0 15.528032929377748 -5.2137300515117 2.992467562555786 0.7936702000257845 0.3993026074167229 0.5766354269809353 0.12751872738103767 0.21331398831977286 3.7428420233563964 0.0378919075823688 0.12240374920254468 6.113218919080015e-06 5.2137300515117 -0.39436759260906157 EHASIDAQSGAGVPNPSTSAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EHASIDAQSGAGVPNPSTSASPK 23 0 Q8IXJ6-5;Q8IXJ6-2;Q8IXJ6-3;Q8IXJ6 Q8IXJ6-5 SIRT2 NAD-dependent protein deacetylase sirtuin-2 1 EHASIDAQSGAGVPNPS(0.029)T(0.089)S(0.291)AS(0.592)PK;EHASIDAQSGAGVPNPS(0.002)T(0.005)S(0.067)AS(0.926)PK 140.81 1.6808e-06 14705100.0 2333.5 2514.7 2646.4 2989.8999999999996 3375.2 2928.8999999999996 3450.7 2010.33 1103.8200000000002 1824.6100000000001 True False 2387.8660097994093 2220.2777549476855 2287.0334156346603 2467.77009237407 3069.91375593996 2899.4379252284243 3190.4109208254895 1957.0095179278583 1873.1019201769511 2058.8164667064593 1.1598246120594415 1.0784243233198536 1.1108486125979387 1.1986352995912375 1.4911060823459308 1.40830325194879 1.5496334774946066 0.9505507409597009 0.9097954822429605 1.0 11.007599511245122 -7.823044102039493 16.358332865382597 0.9475226660597141 1.2799033632877503 0.5028995872075397 0.15107295373367072 3.079387373595096 816.0415587110067 0.09475128120411107 0.04551718153618727 1.5029893317294362e-08 7.823044102039493 0.3323806972280362 EHASIDAQSGAGVPNPSTSAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EHASIDAQSGAGVPNPSTSASPK 23 0 Q8IXJ6-5;Q8IXJ6-2;Q8IXJ6-3;Q8IXJ6 Q8IXJ6-5 SIRT2 NAD-dependent protein deacetylase sirtuin-2 1 EHASIDAQSGAGVPNPS(0.014)T(0.044)S(0.455)AS(0.488)PK 152.92 2.4588e-08 10329000.0 27318.0 23882.0 36611.0 52765.0 59551.0 29280.0 22145.0 30203.0 29237.0 47887.0 True False 25799.774922618544 25713.672607266748 34255.48811904285 45578.31597529802 52069.670987305246 33313.054222623796 23174.78637948502 30290.885729624177 35085.21695003467 46504.37788463182 0.5547816376905996 0.5529301493088951 0.736607813656253 0.9800865649330656 1.119672455709005 0.7163423259906176 0.4983355854577195 0.6513555735498685 0.7544497646452593 1.0 15.505078916310962 -14.522878655706142 0.02633965486963491 1.9437953996222446 1.5273908515073422e-11 0.12146514166104638 0.18816791609193087 6352.987533961865 12.57983550147906 687.2748629548271 309.9907782890925 3.0000006187566843e-15 14.522878655706142 -1.9437953996069706 EHCDT(ph)EGEADDFDPGK ddPTM_A459_Selumetinib_30min_R2 2 EHCDTEGEADDFDPGK 16 0 Q9H8M2 Q9H8M2 BRD9 Bromodomain-containing protein 9 1 EHCDT(1)EGEADDFDPGK;EHCDT(1)EGEADDFDPGK 103.73 0.005760899999999999 15832800.0 164174.0 160277.0 180465.0 158457.0 166322.0 149404.0 147219.0 147563.0 112698.0 165987.0 True False 155049.86632059366 172569.73052821745 168854.07837543593 136874.88324642816 145427.14342245436 169983.04484552194 154064.97520891434 147992.3838996304 135240.74904521665 161194.52402398086 0.9618804811106793 1.0705681943795082 1.0475174600243589 0.8491286169626042 0.9021841424391017 1.054521212024756 0.9557705272047216 0.9180980855008053 0.8389909636452472 1.0 17.298443209012156 -5.7323921750802995 24.993712815533268 0.9327772417787452 1.031046732837498 0.3048208578239271 0.06590203467674599 266.4631680015171 229276.6800267381 0.01857692247154218 0.03216972601546488 1.851858609280562e-06 5.7323921750802995 0.09826949105875271 EHEVFQR ddPTM_A459_Selumetinib_30min_R1 3 EHEVFQR 7 0 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 ;; 124.59 0.0090058 11173200.0 6760.900000000001 8587.0 7780.2 8432.7 7965.599999999999 7168.6 7680.6 7207.7 4227.5 6530.4 False True 6918.415815578666 7581.630048012005 6723.691573579501 6960.08724638376 7245.1128864409 7096.490392568026 7101.246158313465 7016.528382090808 7173.758735616372 7368.640451482706 0.9388999044167712 1.028904870298895 0.9124738298537243 0.9445551444952457 0.9832360439004796 0.963066448864401 0.9637118549982396 0.9522147848425625 0.9735525546198797 1.0 12.847182744574342 -8.581484030232195 6.085058894878863 0.9999987897203765 0.9619377186834994 0.145253870510467 0.028839141137932928 1.0905288859518638 110.00007253989727 0.026913703825480938 0.006974240819155433 2.6212954264812847e-09 8.581484030232195 -0.03806107103687706 EHEVFQR ddPTM_A459_Selumetinib_30min_R2 4 EHEVFQR 7 0 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 ;;; 130.77 0.0058674 15981100.0 48172.9 46539.0 54346.0 52124.0 54507.0 41099.5 40787.8 46302.0 39945.7 45526.8 False True 45495.64306939787 50108.3916535293 50849.43752745087 45024.62128108467 47659.34336123742 46760.58306088548 42684.513519492444 46436.73115429127 47935.956176112464 44212.32299116787 1.0290262983577307 1.1333580382903488 1.1501191090458847 1.0183726670521038 1.077965149462021 1.0576368735528026 0.9654438091393517 1.0503119495342454 1.084221613636733 1.0 15.432160917501077 -5.773677376208467 24.994352358522978 1.038050577487419 1.1070868439217054 0.32502269676148177 0.04472261256677414 253.72571293751832 518198.2083646584 0.01279767241491259 0.019138603580597196 1.6839245314284738e-06 5.773677376208467 0.06903626643428651 EHFAQFGHVR ddPTM_A459_Selumetinib_30min_R1 2 EHFAQFGHVR 10 0 H0YJ07;H0YJU7;H0YJW7;A0A087WUN7;H0YJ40;G3V4X6;G3V2S9;Q9GZT3-2;Q9GZT3 H0YJ07 SLIRP SRA stem-loop-interacting RNA-binding protein, mitochondrial 0 ; 139.38 0.00086498 21852900.0 7716.7 10093.5 8791.7 9237.1 7802.6 8503.5 6091.6 7935.8 3930.0 5428.3 False True 7896.484095915617 8911.74832765916 7597.835429351291 7624.013886841875 7096.856207660914 8417.962510560246 5632.105707624707 7725.316804888692 6668.922964156672 6125.075181119617 1.2892060688914189 1.454961459922874 1.2404477014047792 1.2447216828199428 1.1586561793619754 1.374344356867389 0.9195161758969955 1.2612607317379185 1.0887903849267764 1.0 12.580511836983463 -4.558965980265079 0.1628419351285324 0.9504194112513623 1.7839856417750495 0.4398338044298924 0.11676524077027499 21.19089926453119 0.5606376029078892 0.420255379834095 3.7590193856437155 2.7607941099587916e-05 4.558965980265079 0.8335662305236872 EHFQDDVFNEK ddPTM_A459_Selumetinib_30min_R1 1 EHFQDDVFNEK 11 0 A0A0C4DFS8;P43490 A0A0C4DFS8 NAMPT Nicotinamide phosphoribosyltransferase 0 145.29 0.00098963 10647000.0 8715.4 10089.0 6499.7 7250.4 7647.6 7271.9 8749.7 8733.8 4816.0 7910.0 False True 8918.4518627837 8907.775189751152 5617.076440296479 5984.253746864092 6955.87593029344 7198.751288356916 8089.703084576116 8502.151252619386 8172.400253276982 8925.325549924682 0.9992298670673094 0.9980336448149302 0.6293413510663349 0.6704801649408285 0.779341424734041 0.8065533574198493 0.9063762480511853 0.9525872423433487 0.9156416992930803 1.0 13.123689076851022 -7.389312729929321 2.900442574531552 0.9494430868697029 0.8051063483619045 0.24468060307327255 0.11331872680261004 0.4548951847695634 7.349473518670923 0.06114493790728809 0.03788609768322065 4.0802546657575525e-08 7.389312729929321 -0.14433673850779838 EHFQDDVFNEK ddPTM_A459_Selumetinib_30min_R2 4 EHFQDDVFNEK 11 0 A0A0C4DFS8;P43490 A0A0C4DFS8 NAMPT Nicotinamide phosphoribosyltransferase 0 ;;; 182.41 5.146300000000001e-05 31628400.0 293164.0 225642.0 272356.0 287011.0 280034.0 242585.0 257501.0 280379.0 243013.0 243849.0 False True 276871.1185084757 242948.0158466154 254832.91147879115 247919.6066784093 244853.62538427647 275998.88178262295 269475.3067285513 281194.8564707575 291622.39035054145 236808.44577420954 1.1691775502486295 1.0259263137863748 1.0761141168156116 1.0469204587187484 1.0339733643526288 1.1654942494989406 1.1379463508893966 1.1874359275972328 1.231469550830951 1.0 17.853361010045916 -6.770759695209401 24.999434100283178 1.1557762984618545 1.0669609045298227 0.22379948886297352 0.06716849494965851 248.59794477661376 666798.0478023257 0.02243366782353568 0.020049087451990216 1.6952755746368128e-07 6.770759695209401 -0.08881539393203175 EHIEELLR ddPTM_A459_Selumetinib_30min_R2 1 EHIEELLR 8 0 H0YMC2;B4DIH5;P61201;P61201-2 H0YMC2 COPS2 COP9 signalosome complex subunit 2 0 120.15 0.010573 1816000.0 19062.0 21731.0 23304.0 20402.0 20090.0 15306.0 16506.0 16599.0 15185.0 20895.0 False True 18002.610351231964 23397.69782382185 21804.646011476725 17623.212404586935 17566.11459312124 17414.26256596585 17273.5617060185 16647.300341887625 18222.424304349854 20291.70705827013 0.8871905305716891 1.1530670020335148 1.074559471456098 0.8684933383859581 0.8656794888019024 0.8581960362407488 0.851262126760225 0.8203992051572032 0.8980232294908419 1.0 14.308602617778904 -5.765958285215086 24.99022279336036 0.870070691768471 1.0497518180124943 0.46771975436120805 0.07639528372708404 80.44702143715135 444887.209146122 0.02033309141675646 0.03134402495596869 1.7141219441714522e-06 5.765958285215086 0.17968112624402333 EHIYDLR ddPTM_A459_Selumetinib_30min_R1 3 EHIYDLR 7 0 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 0 ;; 122.13 0.011517 11415400.0 9208.2 10518.5 11453.7 11317.2 10422.3 9014.9 10573.3 8991.0 5597.5 7803.5 False True 9422.73314396182 9286.989130082015 9898.350450670612 9340.863470154793 9479.604805206516 8924.218290874298 9775.747468387339 8752.529473116045 9498.548674775315 8805.155237526844 1.0701382190063964 1.0547217941714002 1.124153996568358 1.060840293916092 1.076597124012672 1.0135219709517462 1.110229996482505 0.9940233007833283 1.0787485760947502 1.0 13.104132724088915 -9.050119418013677 0.2409646021248398 0.9797336952317772 1.087544109868445 0.2553353066884244 0.03608001646581045 6.443500444982978 0.8585070591182532 0.21103166259377995 0.08003350310315395 8.910059044301991e-10 9.050119418013677 0.10781041463666785 EHIYDLR ddPTM_A459_Selumetinib_30min_R2 2 EHIYDLR 7 0 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 0 ; 120.62 0.013050999999999998 8002000.0 85959.0 83561.0 93843.0 93226.0 93549.0 70794.0 70847.0 75708.0 65380.0 85099.0 False True 81181.74290114095 89969.86000903657 87805.24354853277 80528.45797618 81796.53828132889 80545.23089605285 74141.52588066719 75928.29774586589 78457.82686983171 82641.97075624474 0.9823306748164226 1.0886703110506122 1.06247760968234 0.9744256730481583 0.9897699381176487 0.9746286319045282 0.8971413097026704 0.9187619444582092 0.9493702310324338 1.0 16.334587037992016 -6.266495079569821 1.2284048806234142 0.9385372993181228 1.0469234755824144 0.4977644828118005 0.039193108698984964 0.346470997828563 1.0710348850943743 0.01605302453691739 0.023159408438144565 5.413833815642092e-07 6.266495079569821 0.10838617626429159 EHLELFWSR ddPTM_A459_Selumetinib_30min_R1 2 EHLELFWSR 9 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 ; 154.01 0.0013202 39038000.0 9936.5 11494.8 9407.3 10785.900000000001 10386.3 9192.2 9637.0 9473.1 5409.1 8053.8 False True 10168.00111693672 10148.98347221246 8129.840330600043 8902.345041418597 9446.860998850201 9099.734813849816 8910.073331206784 9221.842615034542 9178.847634966894 9087.583680655303 1.1188894071568547 1.116796700735373 0.8946096802284194 0.9796162934234077 1.0395349666996399 1.0013371137610958 0.9804667163806827 1.0147738869976004 1.010042708548133 1.0 13.149681028438263 -5.220812432431197 22.495614714764386 0.9920311987922428 1.117843514649363 0.6670112645710504 0.03609621084142333 96.06419709026149 53190.60554094824 0.009478270634779259 0.02507566735864326 6.014334346581175e-06 5.220812432431197 0.12581231585712027 EHMQPTHPIR ddPTM_A459_Selumetinib_30min_R1 5 EHMQPTHPIR 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 ;;;; 122.94 0.0023279 56759150.0 11698.869999999999 12463.42 8831.97 11650.01 9818.55 9333.07 8672.07 9028.119999999999 7273.530000000001 8181.91 False True 11971.430908961644 11004.19699231324 7632.636984538563 9615.554451272228 8930.463886105796 9239.187789549544 8017.92877797639 8788.664930133285 12342.649172387411 9232.137847052383 1.2967127557333706 1.191944615062982 0.8267464276408627 1.0415306411767087 0.9673234990698384 1.0007636305494951 0.8684801842009255 0.9519642227763433 1.3369221058942642 1.0 13.172449049998837 -5.058839308346018 6.365340900778855 0.9934209716860719 1.273110633749984 0.376307383380011 0.12917600726214581 0.18980157744319173 16.283106468233868 0.032377749943901586 0.09083005847887206 8.732944329772386e-06 5.058839308346018 0.2796896620639121 EHMQPTHPIR ddPTM_A459_Selumetinib_30min_R2 5 EHMQPTHPIR 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 ;;;; 112.13 0.0047529 22422200.0 48639.2 39898.9 41847.0 49507.2 47620.5 37071.4 43876.799999999996 38374.4 36588.5 50036.0 False True 45936.02798214466 42959.01733481599 39154.60957956863 42764.23395531644 41637.9870573285 42177.6488493366 45917.158140229796 38486.063150776106 43907.22236810699 48591.330670859265 0.9453543944556551 0.8840881025836769 0.8057941414444544 0.8800794990568679 0.8569015600616026 0.8680076932865513 0.9449660568313434 0.792035587818479 0.903601975124312 1.0 15.568411320668227 -8.543037155796265 23.255801217072865 1.0000000023991626 0.8708486162376833 0.4024262806248434 0.046852074173141044 1792.808994441529 2068277.0583531223 0.04408452534705601 0.011382575529860519 2.8639329374106673e-09 8.543037155796265 -0.12915138616147936 EHNSMWASLSS(ph)PDAEAVEPDFSSIER ddPTM_A459_Selumetinib_30min_R1 3 EHNSMWASLSSPDAEAVEPDFSSIER 26 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 EHNSMWASLS(0.062)S(0.938)PDAEAVEPDFSSIER;EHNSMWASLS(0.014)S(0.986)PDAEAVEPDFSSIER;EHNSMWASLS(0.065)S(0.935)PDAEAVEPDFSSIER 173.09 9.1751e-18 37048300.0 2620.43 3252.6800000000003 2957.57 3572.77 5112.780000000001 2774.25 4014.95 2670.1299999999997 1327.83 2057.66 True False 2681.480920530818 2871.854713470092 2555.948238769123 2948.852788699055 4650.329951734625 2746.34356381746 3712.099089045209 2599.3094785954086 2253.2305291338826 2321.780704305693 1.154924285294502 1.2369190200195475 1.1008568699141876 1.2700823911709105 2.0029152379079935 1.1828608786025419 1.5988155479805652 1.1195327249360996 0.9704751723344563 1.0 11.181015998574727 -7.963109426387993 8.729492372047718 1.00467566033626 1.3630707612291546 0.27861896668167274 0.25205377781230875 0.3559008642892845 77.51136916331463 0.1447276063274646 0.06888392780093887 1.0886557571826941e-08 7.963109426387993 0.3583951008928945 EHPDAWTR ddPTM_A459_Selumetinib_30min_R1 2 EHPDAWTR 8 0 O14980;C9IYM2;H7BZC5;F8WF71;C9IZS4;C9JQ02;C9JV99;C9J673;C9JKM9 O14980 XPO1 Exportin-1 0 ; 120.87 0.01008 7173000.0 4871.4 6033.2 5275.5 5900.1 4842.1 4754.5 5074.4 4551.4 2656.2 3656.8999999999996 False True 4984.894141905653 5326.830139241417 4559.116076247221 4869.758293593849 4404.13290994219 4706.6740467406025 4691.633922577122 4430.682086969228 4507.377398827724 4126.298736222449 1.2080788281628954 1.2909463128493774 1.1048923909035748 1.1801758924638655 1.0673325397603404 1.1406527611351465 1.1370078180214906 1.0737666781308801 1.0923536289944304 1.0 12.010632558059298 -1.5228787452803458 0.14399137814133717 0.9889642215651393 1.9018879015479029 0.645976502870222 0.04636218964158356 44.86858952090029 0.4292086385600929 0.1811187211459543 8.476007178249022 0.02999999999999943 1.5228787452803458 0.9129236799827636 EHPDAWTR ddPTM_A459_Selumetinib_30min_R2 2 EHPDAWTR 8 0 O14980;C9IYM2;H7BZC5;F8WF71;C9IZS4;C9JQ02;C9JV99;C9J673;C9JKM9 O14980 XPO1 Exportin-1 0 ; 109.48 0.017469 11052800.0 55528.0 40288.0 50925.0 55998.0 60315.0 42555.0 39856.0 50190.0 40787.0 51633.0 False True 52441.97605619601 43377.96005366227 47648.540942947664 48370.97579806191 52737.690477058575 48416.564974171975 41709.38297316574 50336.044590598205 48945.539683998526 50142.22113135496 1.0458646400768026 0.8650984953384352 0.950267855469052 0.9646755709394481 1.0517621534735049 0.9655847683200476 0.8318216072619089 1.0038654741427486 0.97613425531706 1.0 15.613738283663414 -5.73948097790959 5.474034221811793 0.9681748047420637 0.9444941478447059 0.007051638650666048 0.06673952256136235 0.9369609740787364 80.03227130716355 0.01891903972710951 0.031855097223760245 1.821876869518071e-06 5.73948097790959 -0.023680656897357877 EHPGQPEDS(ph)PEAEASTLDVFTER ddPTM_A459_Selumetinib_30min_R1 2 EHPGQPEDSPEAEASTLDVFTER 23 0 F8VW41;Q86VP3-4;Q86VP3;Q86VP3-3;Q86VP3-2 F8VW41 PACS2 Phosphofurin acidic cluster sorting protein 2 1 EHPGQPEDS(0.998)PEAEAS(0.001)TLDVFTER;EHPGQPEDS(1)PEAEASTLDVFTER 152.12 3.2934e-08 5870200.0 1015.34 928.29 1068.97 1110.56 939.21 862.9 936.17 895.22 470.66 975.27 True False 1038.995446492279 819.6053752496872 923.8097454319013 916.6215437930861 854.2586213309934 854.2200094505127 865.5539431852089 871.4758575156204 798.6756443536846 1100.4554044342663 0.9441504329077439 0.7447874506746037 0.8394794934073891 0.8329474689292953 0.7762773647062596 0.7762422775229672 0.7865415896886635 0.7919229202782987 0.7257682965937872 1.0 10.103884966370298 -4.747010852881648 24.836280957938257 0.8007909941840157 0.944150834632822 0.2351836715960275 0.07243281233245995 930.8163525488267 1602145.4409071894 0.01642885863323905 0.34810329132174156 1.7905611079208274e-05 4.747010852881648 0.14335984044880634 EHQT(ph)SAYSPPR ddPTM_A459_Selumetinib_30min_R1 1 EHQTSAYSPPR 11 0 H3BRF9;Q96K21-3;Q96K21-2;Q96K21;Q96K21-4 H3BRF9 ZFYVE19 Abscission/NoCut checkpoint regulator 1 EHQT(0.927)S(0.069)AYS(0.004)PPR 95.183 0.029114 10173000.0 984.57 1050.0 615.31 763.54 992.5 701.94 976.04 840.94 364.24 735.67 True False 1007.5085653602761 927.0655118682432 531.7542816558962 630.2020724209161 902.7285502401074 694.8791209105262 902.4165169856876 818.635539441909 618.0886769629583 830.1004105326289 1.213718909877197 1.1168112918693742 0.6405903128209506 0.7591877614137678 1.0874931981552414 0.8371024903657875 1.0871172999500838 0.986188573159043 0.7445950744276412 1.0 9.697142047940003 -5.0200534970441195 23.863351808741893 0.8980438077295885 1.1894922023634769 0.3764412761372873 0.1425535045952286 385.2982511791246 458504.95855869947 0.03721525235778269 0.10171104264553332 9.54874955850805e-06 5.0200534970441195 0.2914483946338884 EHQTSAYS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 EHQTSAYSPPR 11 0 H3BRF9;Q96K21-3;Q96K21-2;Q96K21;Q96K21-4 H3BRF9 ZFYVE19 Abscission/NoCut checkpoint regulator 1 EHQTSAYS(1)PPR 164.92 0.00065754 15336000.0 11577.0 8729.2 18020.0 21567.0 25280.0 14034.0 11301.0 18004.0 20021.0 15685.0 True False 10933.596686402923 9398.701571198097 16860.612818692538 18629.53739484983 22104.100393932553 15967.056112032193 11826.518892506669 18056.388659277345 24025.759433479627 15232.133295475815 0.717798122844052 0.617031205602019 1.1069107978263562 1.223041909722724 1.4511493541418667 1.0482481870595672 0.7764190782140367 1.1854143020557981 1.577307588334699 1.0 13.894830388300099 -5.3154630266328775 4.806641713430105 1.175081071673839 0.6653462547504363 0.4738104434073547 0.2129149285979477 0.1748261106731255 8.777665385560697 0.05968091350369029 0.13407174186896928 4.836564383132694e-06 5.3154630266328775 -0.5097348169234026 EHS(ph)PSESEKEVVGADPR ddPTM_A459_Selumetinib_30min_R2 1 EHSPSESEKEVVGADPR 17 1 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 EHS(0.97)PS(0.03)ESEKEVVGADPR 57.788 0.038375 30979000.0 74528.0 59006.0 67726.0 73458.0 78848.0 51634.0 57926.0 58995.0 40508.0 81371.0 True False 70386.03211922225 63531.57046580609 63368.5828944933 63452.89367788201 68942.40932993648 58746.114813215754 60619.67377819147 59166.665682851984 48610.731888087175 79021.60780275166 0.8907188056071328 0.803977193483449 0.8019146238161798 0.802981557098519 0.8724500962069236 0.7434183693130338 0.7671278206526265 0.7487403423952063 0.6151574643915872 1.0 16.26995957976859 -6.7761288671059745 24.865422510058114 0.7586999976932837 0.8291666820868493 0.07850893239184409 0.09325174187795071 485.9778462346324 822627.0539605175 0.031014783943550197 0.027468049853152043 1.6744459481821086e-07 6.7761288671059745 0.07046668439356563 EHS(ph)PYGPSPLGWPSSETR ddPTM_A459_Selumetinib_30min_R1 1 EHSPYGPSPLGWPSSETR 18 0 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5 G3V599 MIA2 Melanoma inhibitory activity protein 2 1 EHS(0.934)PY(0.065)GPS(0.001)PLGWPSSETR 65.111 0.022494 3977100.0 872.01 1251.9 1311.5 1308.0 1385.3 1465.8 1221.6 1438.8 686.95 1135.7 True False 892.3261363639094 1105.32696600748 1133.4055035538308 1079.5823542009043 1259.9998595945792 1451.0553828399154 1129.453728484198 1400.6383501189366 1165.7039771571062 1281.4781576547996 0.6963256697226371 0.8625406210826961 0.8844516754214893 0.8424508429988541 0.983239434919806 1.132329391782576 0.8813679123108759 1.0929865185390355 0.9096557519875573 1.0 10.323593173270778 -4.254901990794542 0.5263954435885666 1.0075505289665843 0.3281798796832271 0.5616877101152999 0.0802388184525416 5.259248273389224 0.7395530917598113 0.044807920973942005 2.4719213822438637 5.560297248623135e-05 4.254901990794542 -0.6793706492833571 EHSLEDNS(ph)SPNSLEPLK ddPTM_A459_Selumetinib_30min_R2 1 EHSLEDNSSPNSLEPLK 17 0 A0A0U1RR07;Q9HCH5-15;Q9HCH5-14;Q9HCH5-6;Q9HCH5;Q9HCH5-13 A0A0U1RR07 SYTL2 Synaptotagmin-like protein 2 1 EHSLEDNS(0.463)S(0.463)PNS(0.073)LEPLK 72.568 0.017932 3529600.0 38707.0 26154.0 31357.0 29245.0 32537.0 26090.0 28050.0 30231.0 22282.0 29978.0 True False 36555.81989639784 28159.9277016353 29339.524758920186 25261.780549561074 28449.411175529396 29683.66067856064 29354.380580020537 30318.967204988552 26739.022611098022 29112.457247801965 1.2556762071040177 0.9672810323752873 1.007799668340788 0.8677309625407308 0.9772246613664798 1.0196205846142308 1.0083099592095353 1.0414430821457945 0.9184735724469586 1.0 14.829348995361997 -4.75989378868476 24.999432273969063 0.979555594182537 1.2556765462868846 0.743142780660834 0.048856571782068044 20.388341745190687 329667.0648834476 0.012446426590460387 0.07644878028529528 1.738225878320474e-05 4.75989378868476 0.2761209521043476 EHSLQVS(ph)PSLEK ddPTM_A459_Selumetinib_30min_R1 2 EHSLQVSPSLEK 12 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 EHSLQVS(0.992)PS(0.008)LEK;EHSLQVS(0.991)PS(0.009)LEK 114.06 0.003766 49279000.0 13604.2 15776.0 17514.6 18558.3 15972.0 12688.8 15076.5 15186.3 7727.5 12697.3 True False 13921.151390834844 13928.938585936578 15136.213520811223 15317.44128743627 14527.335420085623 12561.162192508593 13939.267466840214 14783.509991945512 13113.003105730468 14327.12213717557 0.9716641805343919 0.9722077087480258 1.0564727079094447 1.0691219870102908 1.0139744242418753 0.8767400788686851 0.9729286407541008 1.0318548170665567 0.9152572987219294 1.0 13.806461226735875 -6.560824396567375 24.999908010192406 0.9603244403969515 1.0200111965266214 0.25270567059300386 0.049224914819452646 244.33350277498957 160973.8269151019 0.016981367301280137 0.016981390662508727 2.7490054663576247e-07 6.560824396567375 0.05968675612966989 EHSLQVS(ph)PSLEK ddPTM_A459_Selumetinib_30min_R2 4 EHSLQVSPSLEK 12 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 EHSLQVS(0.992)PS(0.008)LEK;EHSLQVS(0.994)PS(0.006)LEK;EHSLQVS(0.989)PS(0.011)LEK;EHSLQVS(0.923)PS(0.077)LEK 101.3 0.0083708 64174000.0 384658.0 385659.0 433958.0 467417.0 463062.0 360652.0 384600.0 422734.0 339614.0 442275.0 True False 363280.2482679778 415237.8052108647 406037.61473774625 403753.99826070113 404888.0117331955 410328.5393271081 402484.66207044246 423964.08595261874 407546.289608 429505.3715815459 0.8458107215988692 0.9667814017828358 0.9453609700912807 0.9400441181305328 0.942684395872156 0.9553513564130202 0.9370887739736374 0.9870984485979237 0.9488735568249425 1.0 18.712316648886926 -4.757869551513759 24.999776596148248 0.9555461643081551 0.8458105670936448 0.7388480998135016 0.019981582763031448 50.77841894063112 355551.3009855679 0.004723906030026894 0.03396342876414471 1.7463466220836597e-05 4.757869551513759 -0.10973559721451032 EHSNPS(ph)PSQDTDGTK ddPTM_A459_Selumetinib_30min_R1 3 EHSNPSPSQDTDGTK 15 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 EHSNPS(0.999)PS(0.001)QDTDGTK;EHS(0.01)NPS(0.967)PS(0.022)QDTDGTK;EHSNPS(0.995)PS(0.005)QDTDGTK 164.5 6.2255e-05 107723800.0 24168.8 26690.6 27705.3 28139.7 26513.6 22252.4 25416.4 23760.3 12214.4 21772.6 True False 24731.886015701726 23565.652143876705 23943.072434319423 23225.62964258958 24115.449561356276 22028.56105956265 23499.220485138954 23130.099659668453 20726.944695520422 24567.32529308348 1.0066983572959234 0.9592274235287316 0.9745901171040462 0.9453869872081015 0.9816066370133333 0.8966609428078206 0.956523357947915 0.9414984897106543 0.8436793362017211 1.0 14.584453175936764 -5.823048492448288 0.6418699492181859 0.9255771435781792 0.9965040480367632 0.20595571769353294 0.04149589250236735 1.8830870254942162 1.3364231234277002 0.023694545226095508 0.08312125564339409 1.5029741376514485e-06 5.823048492448288 0.07092690445858396 EHSNPS(ph)PSQDTDGTK ddPTM_A459_Selumetinib_30min_R2 4 EHSNPSPSQDTDGTK 15 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 EHS(0.019)NPS(0.969)PS(0.012)QDTDGTK;EHS(0.002)NPS(0.974)PS(0.024)QDTDGTK;EHS(0.034)NPS(0.96)PS(0.006)QDTDGTK;EHSNPS(0.993)PS(0.003)QDT(0.004)DGTK 158.14 0.00014873 132247900.0 211882.0 186111.0 207103.0 222336.0 235967.0 163419.0 188625.0 187257.0 148414.0 192000.0 True False 200106.44667084923 200385.1152588153 193778.21845669716 192053.45324900668 206322.715888255 185928.4838800189 197396.43625334665 187801.88686793487 178100.94703363694 186456.46112409045 1.0732073614637276 1.0747019119141978 1.039267919644436 1.0300176893370905 1.106546346768553 0.9971683617672 1.0586730814437983 1.0072157635929226 0.9551878543651392 1.0 17.508479264952378 -7.920346974809172 3.3935088767627595 0.9775078193667416 1.0534560872293355 0.5315643763993976 0.02947802903951319 0.18349647670184194 4.131933449832045 0.01875293955686315 0.007791328775580135 1.2013042822470087e-08 7.920346974809172 0.0759482678625939 EHSNPSPS(ph)QDTDGTK ddPTM_A459_Selumetinib_30min_R1 2 EHSNPSPSQDTDGTK 15 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 EHSNPS(0.201)PS(0.791)QDT(0.006)DGT(0.002)K;EHSNPS(0.023)PS(0.923)QDT(0.054)DGTK 300.18 1.4233999999999997e-80 50597600.0 3734.44 4674.12 3854.31 4030.06 4004.8900000000003 3658.05 4009.33 3557.38 1785.6799999999998 3114.09 True False 3821.4451860446998 4126.8718574605655 3330.9158722093507 3326.2856745954873 3642.6484066207568 3621.2533382436536 3706.9030101698963 3463.02672640124 3030.1685390929506 3513.8137853053086 1.0875491473184775 1.1744708483753614 0.94794888850945 0.9466311756490741 1.0366651818187498 1.0305763365684473 1.0549514677391507 0.9855464569248209 0.8623588853128895 1.0 11.778822022355834 -5.262399561274201 24.99999056274821 0.9874430627385025 1.1310100030686978 0.5241159987357757 0.05625931407492086 66.0222664460317 1719056.210917566 0.015265583560530198 0.03510469235827795 5.465129266088565e-06 5.262399561274201 0.14356694033019535 EHSPYGPS(ph)PLGWPSSETR ddPTM_A459_Selumetinib_30min_R1 2 EHSPYGPSPLGWPSSETR 18 0 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5 G3V599 MIA2 Melanoma inhibitory activity protein 2 1 EHSPYGPS(1)PLGWPSSETR;EHSPYGPS(1)PLGWPSSETR 116.04 0.0006942999999999999 8903600.0 2403.5099999999998 3568.8 3396.4 3400.4 3490.1000000000004 3729.4 3741.6000000000004 3097.6000000000004 1634.08 3141.6 True False 2459.507106583662 3150.96323690989 2935.1875350897667 2806.58397341342 3174.421071227203 3691.88562202427 3459.3680996205603 3015.4415855771613 2772.9144115188637 3544.8549617754 0.6938244676029978 0.8888835427364752 0.8280134354551171 0.7917345007559279 0.8955009740757716 1.0414772005721868 0.9758842426342812 0.8506530219411041 0.7822363513936494 1.0 11.791510885269904 -6.374231426195417 4.782157729428569 0.9276510929829279 0.8092952338716501 0.35247051768073634 0.08257150728106971 0.30256213381503155 10.722555680771976 0.02756116738480211 0.03136680799273863 4.224434432449107e-07 6.374231426195417 -0.11835585911127777 EHSPYGPS(ph)PLGWPSSETR ddPTM_A459_Selumetinib_30min_R2 2 EHSPYGPSPLGWPSSETR 18 0 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5 G3V599 MIA2 Melanoma inhibitory activity protein 2 1 EHSPYGPS(1)PLGWPSSETR;EHSPYGPS(1)PLGWPSSETR 110.38 0.00091398 8909100.0 42700.0 21208.7 34676.0 37744.0 24505.0 16010.300000000001 52074.0 35869.0 34917.0 25948.0 True False 40326.90494164333 22835.339093281036 32444.98391237414 32603.2020879683 21426.46282252044 18215.57349796701 54495.54418267346 35973.37285156737 41901.37566249481 25198.81381899945 1.600349335143608 0.9062069055037664 1.2875599679184586 1.2938387624970695 0.8502964852403201 0.7228742443516447 2.162623390692494 1.4275819929446083 1.6628312730697636 1.0 14.621068203047486 -7.248062050646311 24.99829040912669 1.598891043497595 1.1055127154154216 0.27663033347069177 0.3570212332061394 953.1744747230234 1781205.057421212 0.13305325420382155 0.10245561637058534 5.648562641384662e-08 7.248062050646311 -0.4933783280821733 EHTALLK ddPTM_A459_Selumetinib_30min_R1 1 EHTALLK 7 0 F8WBS5;F8WB72;C9K025;P18077 F8WBS5 RPL35A 60S ribosomal protein L35a 0 104.45 0.025267 5564000.0 3459.9 3713.2 4648.1 4321.5 4408.6 3947.6 4101.4 4275.9 2942.0 3351.7 False True 3540.5089382065444 3278.4568177801516 4016.9135501857095 3566.831149601838 4009.8429084015474 3907.890728134018 3792.0280959439156 4162.4892419193475 4992.35912482161 3781.9233433227014 0.9361662352193377 0.8668755339974139 1.0621351057466308 0.9431262418101027 1.06026551687814 1.0333077572906713 1.002671855483019 1.1006276077140926 1.3200582538607064 1.0 11.884904405927289 -6.575879527895759 0.5779072280641501 1.1365453132139878 0.9148372888515444 0.3720869987749348 0.09228297258285713 0.993818466235138 0.7216365863681533 0.07393754830892092 0.10441562249703736 2.6553420444593286e-07 6.575879527895759 -0.2217080243624434 EHTALLK ddPTM_A459_Selumetinib_30min_R2 2 EHTALLK 7 0 F8WBS5;F8WB72;C9K025;P18077 F8WBS5 RPL35A 60S ribosomal protein L35a 0 ; 127.12 0.008648399999999999 9267600.0 70337.0 57778.0 57725.0 63144.0 62787.0 47764.0 60712.0 57404.0 51280.0 66552.0 False True 66427.9511213201 62209.386814448415 54011.03634622786 54543.67827052437 54899.13573709824 54343.05744157801 63535.2282985457 57571.03613625621 61537.43288291472 64630.470837137844 1.0278116538669775 0.9625395886594992 0.8356899717213903 0.8439313154312127 0.8494311588018355 0.8408271940106539 0.983053774413124 0.8907723460862496 0.9521427290539587 1.0 15.979926881329769 -10.213087973926513 9.126378785247194 0.9999999796481325 0.9048483689074895 0.14366232734615447 0.06531674515128513 0.0 0.0 0.0672886471178791 0.016319894086584057 6.122263620289513e-11 10.213087973926513 -0.09515161074064293 EHVIEALR ddPTM_A459_Selumetinib_30min_R1 2 EHVIEALR 8 0 X1WI28;P27635;F8W7C6;A0A087WV22;H7C123;H7C2C5 X1WI28 RPL10 60S ribosomal protein L10 0 ; 124.08 0.007862899999999999 16435000.0 13724.3 16139.9 12690.5 13425.1 14157.6 12225.2 15022.0 14829.699999999999 7448.700000000001 13524.0 False True 14044.04948716092 14250.233004764057 10967.199803926715 11080.658305338342 12877.047579727292 12102.22558759348 13888.878445718412 14436.368182345552 12639.899868476798 15259.937134915488 0.9203215821267995 0.9338330085357182 0.7186923318860352 0.726127388820315 0.8438466990970738 0.7930717853288525 0.9101530578353415 0.9460306457825721 0.8283061559641739 1.0 13.897461398384246 -7.283807321493208 13.754977500179903 0.9166351680418448 0.8195547211851542 0.2814486660601846 0.0768535227436129 4.412027225486013 2709.373765182065 0.034123468680686456 0.023189221240073103 5.2022674844298855e-08 7.283807321493208 -0.0970804468566906 EHVIEALR ddPTM_A459_Selumetinib_30min_R2 4 EHVIEALR 8 0 X1WI28;P27635;F8W7C6;A0A087WV22;H7C123;H7C2C5 X1WI28 RPL10 60S ribosomal protein L10 0 ;;; 140.14 0.0033163000000000003 34221400.0 190906.0 166549.0 189679.0 201199.0 227990.0 178819.0 194333.0 201148.0 179536.0 182432.0 False True 180296.20877726818 179322.7727605591 177475.25964688035 173795.3491123659 199347.85794353983 203449.69409273783 203369.86956353398 201733.30737815597 215448.21665497212 177164.71414473996 1.0176756113520995 1.0121810859811287 1.0017528631682644 0.9809817375393309 1.1252119752281862 1.1483646451545853 1.14791407840607 1.138676560691109 1.216089883897283 1.0 17.434731765702196 -6.307835297732537 6.066721966073696 1.138953004020864 1.0036994905103742 0.5888123343036638 0.05133602883362891 0.13376725569610398 12.57478166637392 0.015045318935521556 0.01728707890688944 4.922261726279891e-07 6.307835297732537 -0.13525351351048975 EHVIEALRR ddPTM_A459_Selumetinib_30min_R1 2 EHVIEALRR 9 1 X1WI28;P27635;F8W7C6;A0A087WV22;H7C123;H7C2C5 X1WI28 RPL10 60S ribosomal protein L10 0 ; 131.62 0.0048173 19610400.0 5330.9 4080.7 6980.0 6545.1 5495.700000000001 4562.4 4799.1 4974.6 3207.9 4130.6 False True 5455.099597874294 3602.929746934037 6032.15433839553 5402.121151743374 4998.614905344643 4516.506398327759 4437.100023222422 4842.657448221895 5443.572004253992 4660.80274545119 1.1704206111701068 0.7730277258462382 1.2942307726459223 1.1590538039859526 1.072479394289567 0.9690404518268316 0.9520033920235961 1.0390178929902556 1.1679473046926867 1.0 12.1863627410744 -5.255213988667479 24.999448843006146 1.0768897838453901 0.9717242193127518 0.09831636219263384 0.13260239171357194 1272.7119569772274 5110828.062906457 0.034112445625266996 0.08561295418031449 5.55630415639193e-06 5.255213988667479 -0.10516556453263837 EHYPVS(ph)SPSS(ph)PSPPAQPGGVSR ddPTM_A459_Selumetinib_30min_R1 1 EHYPVSSPSSPSPPAQPGGVSR 22 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 2 EHY(0.011)PVS(0.727)S(0.261)PS(0.094)S(0.867)PS(0.039)PPAQPGGVSR 84.31200000000003 0.0026992 4927500.0 1291.0 1336.3 1278.7 1345.8 1419.9 1170.1 1230.5 1149.0 732.64 1055.1 True False 1321.0777881512906 1179.8453747709843 1105.0595633963273 1110.781293794783 1291.470295703706 1158.3298563657966 1137.682394318767 1118.524787522003 1243.2365700915389 1190.532362544316 1.109652983584573 0.9910233538292968 0.9282062362712068 0.9330122630357609 1.0847838633665305 0.9729511710965181 0.9556081213007919 0.9395164908676453 1.044269445506368 1.0 10.21739112294997 -4.767538149972161 5.042207988300546 0.9794784109874771 1.1171386192108108 0.38749121207374715 0.04766127927628485 0.17237052755144142 11.708967792582992 0.012090495911181762 0.0834187403906882 1.7078976856619915e-05 4.767538149972161 0.1376602082233337 EHYPVS(ph)SPSS(ph)PSPPAQPGGVSR ddPTM_A459_Selumetinib_30min_R2 2 EHYPVSSPSSPSPPAQPGGVSR 22 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 2 EHY(0.002)PVS(0.713)S(0.285)PS(0.363)S(0.624)PS(0.013)PPAQPGGVSR;EHY(0.004)PVS(0.498)S(0.498)PS(0.368)S(0.584)PS(0.048)PPAQPGGVSR 77.646 0.0061445 10878000.0 26756.0 26854.0 34936.0 40912.0 42428.0 33403.0 28371.0 30755.0 34308.0 33308.0 True False 25269.00863275429 28913.615450780544 32688.255795440764 35339.71502286349 37097.815328867495 38003.96004775624 29690.307716069987 30844.49195823565 41170.5586456131 32346.311495422906 0.781202166940423 0.8938767393887214 1.0105713537095642 1.0925423452953564 1.146894765238285 1.1749086152569177 0.9178885116552238 0.9535706092053257 1.272805359938454 1.0 14.981313588192162 -5.127470676610975 1.7446294627502215 1.077493916576391 0.7677883742748692 0.49072982400294163 0.1002483625122194 0.4460209517575132 2.131600668968183 0.029476634227729833 0.18313182066606026 7.456402156561171e-06 5.127470676610975 -0.3097055423015218 EHYPVSSPS(ph)SPSPPAQPGGVSR ddPTM_A459_Selumetinib_30min_R2 1 EHYPVSSPSSPSPPAQPGGVSR 22 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 EHYPVSSPS(0.499)S(0.499)PS(0.002)PPAQPGGVSR 159.72 3.9374e-09 6517600.0 22916.0 20367.0 25741.0 28470.0 31560.0 21370.0 21699.0 21561.0 22115.0 24622.0 True False 21642.42046001635 21929.083409773117 24084.85208468171 24592.336886510642 27595.150650020234 24313.52352245459 22708.046495752802 21623.738940384297 26538.617944728147 23911.098884361203 0.9051202776034414 0.9171089758704314 1.0072666338406615 1.0284904514612248 1.1540728756748417 1.0168300352919617 0.9496864450092152 0.9043389868847505 1.1098870057404784 1.0 14.54539281317861 -5.2717326406932 3.5750614021766998 1.0212902228974872 0.9068606906663305 0.30522038374610205 0.06694882300895223 0.3023345537168137 8.408323138092275 0.01914752240293899 0.0511310066239285 5.348935479172449e-06 5.2717326406932 -0.1144295322311567 EHYPVSSPSS(ph)PSPPAQPGGVSR ddPTM_A459_Selumetinib_30min_R1 2 EHYPVSSPSSPSPPAQPGGVSR 22 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 EHYPVSSPS(0.064)S(0.933)PS(0.002)PPAQPGGVSR;EHYPVSSPS(0.063)S(0.935)PS(0.002)PPAQPGGVSR 140.04 6.0884e-06 55559000.0 5226.4 6035.4 5523.4 6077.3 6171.1 5349.4 5907.0 5323.1 2484.91 4084.7999999999997 True False 5348.164951195899 5328.772562218661 4773.352617864451 5016.01364004981 5612.925094596197 5295.589892866582 5461.430234247019 5181.9140961343555 4216.710779354339 4609.123869321409 1.1603430723122001 1.1561356807282344 1.0356312291010787 1.0882792006169941 1.2177856906723956 1.1489363364943022 1.1849172183456838 1.124273125013079 0.9148616741287875 1.0 12.170276825010625 -8.219794464429583 7.470817714172038 0.9576622191363499 1.1396762965446805 0.6692271088907289 0.05122218475470805 0.1394618107882296 22.276826029186818 0.03783047987104476 0.013868859499503864 6.028448228071071e-09 8.219794464429583 0.18201407740833064 EHYPVSSPSS(ph)PSPPAQPGGVSR ddPTM_A459_Selumetinib_30min_R2 2 EHYPVSSPSSPSPPAQPGGVSR 22 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 EHYPVSSPS(0.099)S(0.885)PS(0.016)PPAQPGGVSR;EHYPVSSPS(0.086)S(0.907)PS(0.007)PPAQPGGVSR 104.55 4.5262e-05 27173000.0 49304.0 43446.0 53376.0 63869.0 68077.0 44305.0 48521.0 46336.0 45357.0 48826.0 True False 46563.881059549945 46778.16849909182 49941.84627139469 55169.93201982956 59524.55864389822 50407.6115892537 50777.32264253749 46470.83008866227 54429.667380467305 47416.26651481684 0.9820233536311734 0.9865426347828203 1.0532639944519597 1.1635233238489966 1.2553615672228797 1.0630868960022846 1.0708840314677743 0.9800609264363077 1.1479112840623773 1.0 15.533094451213588 -5.41745966693061 3.6999899071488813 1.10092916437679 0.9849277886703843 0.2562014510241276 0.07577568511781357 0.3336831517481482 8.177258418776796 0.021838557567589283 0.049051806189142066 3.824197674568326e-06 5.41745966693061 -0.11600137570640567 EHYVDLK ddPTM_A459_Selumetinib_30min_R1 3 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 ;; 122.74 0.010892 52073000.0 38649.0 45295.7 35345.4 34582.2 39582.5 35814.4 39538.3 39836.5 24348.9 34887.3 False True 39549.44650213728 39992.45838660037 30545.68881838471 28543.067958292442 36002.26986385798 35454.13965287339 36555.89419853205 38779.9066128114 41318.30492670596 39365.42478607936 1.00467470418668 1.0159285363724244 0.7759522216355318 0.7250796381190332 0.9145657657577042 0.900641612418492 0.928629486336933 0.9851260801464787 1.049609019875665 1.0 15.264641425752364 -7.689405038458605 1.665654445091889 1.0256575474739154 0.8824127408423076 0.29882568618595395 0.08458192990110426 0.5357113351543569 2.86056810420481 0.06951509074778688 0.02920058995447217 2.0445369395045192e-08 7.689405038458605 -0.14324480663160777 EHYVDLK ddPTM_A459_Selumetinib_30min_R2 4 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 ;;; 120.46 0.013218 85110000.0 1004640.0 851840.0 973930.0 1038250.0 1002130.0 794060.0 873940.0 937560.0 733620.0 866360.0 False True 948806.1306925657 917173.3889026914 911268.4041348062 896838.5589188513 876233.4702441299 903434.5572410064 914579.9416792562 940288.1443785856 880364.499055459 841345.9357263905 1.1277241505581146 1.0901263677120328 1.0831078697112229 1.0659569635224426 1.0414663374912707 1.0737967807035411 1.0870438696416094 1.1175999127716374 1.0463763615799502 1.0 19.682339588995347 -14.52287874528023 0.2520168155938231 0.504630221294506 1.0880638835721375 0.5048832400052686 0.025034354915420855 171.91747746265298 1.6986781740545507 43.936699131369316 0.037933467453467096 3.0000000000007374e-15 14.52287874528023 0.5834336622776315 EIAATCSGTEWGQS(ph)SGAASPGLFQAGHR ddPTM_A459_Selumetinib_30min_R1 1 EIAATCSGTEWGQSSGAASPGLFQAGHR 28 0 G3V3Z8;P49757-3;P49757 G3V3Z8 NUMB Protein numb homolog 1 EIAATCSGTEWGQS(0.768)S(0.134)GAAS(0.098)PGLFQAGHR 134.98 1.6113e-12 27844000.0 2815.6 3636.5 2956.2 3252.9 3337.8 2962.8 3557.0 3224.7 1540.0 2772.7 True False 2881.1980017961055 3210.7368894370147 2554.76427724425 2684.8420794955055 3035.8965793364528 2932.996922007164 3288.6926262428688 3139.170480698175 2613.2675228501985 3128.6030533851044 0.9209215591216309 1.0262525589377798 0.8165830671551736 0.8581600265941517 0.9703680932138884 0.9374781242490007 1.0511696658623886 1.0033776823498388 0.835282545678871 1.0 11.61130291056573 -6.303182286549456 22.201033625772617 0.9692527675880155 0.9077562266243282 0.1429099682218914 0.07264035405318288 283.383099865721 150716.2039789593 0.023394742016147572 0.026527820539262656 4.975282134851151e-07 6.303182286549456 -0.061496540963687285 EIAATCSGTEWGQSSGAAS(ph)PGLFQAGHR ddPTM_A459_Selumetinib_30min_R1 2 EIAATCSGTEWGQSSGAASPGLFQAGHR 28 0 G3V3Z8;P49757-3;P49757 G3V3Z8 NUMB Protein numb homolog 1 EIAATCSGTEWGQS(0.046)S(0.001)GAAS(0.953)PGLFQAGHR;EIAATCSGTEWGQS(0.001)S(0.004)GAAS(0.995)PGLFQAGHR 183.91 3.351300000000001e-27 31083000.0 2514.5 2970.0 2555.1 2853.8 2979.3 2718.3 3410.3999999999996 2564.9 1338.08 2767.3999999999996 True False 2573.082957634717 2622.2710192844593 2208.1314541596585 2355.437402460658 2709.822841038137 2690.956370018926 3153.1507822712088 2496.8705200306217 2270.624030503503 3122.622746758734 0.8240133907644026 0.8397655534938899 0.7071400016065621 0.7543137911569977 0.8678034654845574 0.861761598583154 1.0097764084835936 0.7996068441576428 0.7271528502315557 1.0 11.608542568315828 -6.2774107085086435 19.129219581466288 0.8734726422283694 0.7801860658386569 0.2327934714406944 0.08549764271009343 62.411697916061065 74750.65593600195 0.027429532216923774 0.03132673598015905 5.279457419318442e-07 6.2774107085086435 -0.0932865763897125 EIAATCSGTEWGQSSGAAS(ph)PGLFQAGHR ddPTM_A459_Selumetinib_30min_R2 3 EIAATCSGTEWGQSSGAASPGLFQAGHR 28 0 G3V3Z8;P49757-3;P49757 G3V3Z8 NUMB Protein numb homolog 1 EIAATCSGTEWGQSSGAAS(0.999)PGLFQAGHR;EIAATCSGTEWGQS(0.003)S(0.005)GAAS(0.992)PGLFQAGHR;EIAATCSGTEWGQS(0.005)S(0.006)GAAS(0.989)PGLFQAGHR 131.94 1.8801e-12 47454000.0 71188.0 71099.1 80685.0 75927.0 87201.0 82025.0 75242.0 73772.0 71146.3 83535.0 True False 67231.65594814302 76552.17235036098 75493.81494318582 65585.61161861924 76246.03079316893 93323.1992011858 78740.90208919455 73986.66430638795 85377.54799371508 81123.12750000453 0.828760650877757 0.9436541059188911 0.930607796687592 0.808469959674762 0.9398803170299946 1.150389563089522 0.9706344481010074 0.9120292398290958 1.0524439900780491 1.0 16.307825652474662 -6.527745461829464 24.999583422325074 1.0127458557353002 0.884818097086751 0.47707968960708436 0.06865219890298503 131.54085286598334 675698.0840237299 0.023029293778308275 0.023108458335451942 2.966569574062346e-07 6.527745461829464 -0.12792775864854922 EIADGLCLEVEGK ddPTM_A459_Selumetinib_30min_R1 1 EIADGLCLEVEGK 13 0 Q5W0H4;A0A0B4J2C3;P13693;J3KPG2;E9PJF7 Q5W0H4 TPT1 Translationally-controlled tumor protein 0 146.16 0.0084166 3037100.0 1307.9 1192.7 1254.7 1351.5 1303.1 934.85 1067.2 1290.6 729.41 1009.1 False True 1338.3715252696154 1053.0581295288123 1084.3186315737637 1115.4858957970343 1185.2348350809912 925.4462577758858 986.7002447923511 1256.3690955403802 1237.7554960014054 1138.6278144663727 1.1754249354051256 0.9248484150392344 0.9523029543081543 0.9796756074501974 1.0409326208463134 0.8127732750052341 0.8665695956626321 1.1034062927131179 1.0870588969245316 1.0 10.153080532172478 -7.783237772666948 24.9748345772677 1.0714244831663813 0.9603120946978786 0.18098231551307697 0.09560025588348717 393.1190440913708 450397.3581347503 0.05310975730974169 0.02554751527557317 1.6472602831046723e-08 7.783237772666948 -0.11111238846850269 EIAIVHS(ph)DAEK ddPTM_A459_Selumetinib_30min_R2 2 EIAIVHSDAEK 11 0 Q9H307 Q9H307 PNN Pinin 1 EIAIVHS(1)DAEK;EIAIVHS(1)DAEK 90.926 0.027725 4964300.0 38513.8 28153.0 41116.0 53201.0 49828.0 44038.0 79855.0 86194.0 63652.0 32489.0 True False 36373.35717895695 30312.244573837223 38470.641323716 45954.932023156034 43568.161172028114 50103.83476283836 83568.41572968061 86444.81026981518 76384.17858547758 31550.95815344045 1.1528447726393578 0.9607392722091341 1.2193176871720772 1.4565304736441076 1.380882347855964 1.5880289441344535 2.6486807571188753 2.7398473874996685 2.420978095625547 1.0 14.945396197823113 -7.059233157965376 3.4529427352595587 2.343129793627988 1.2387638315354943 0.471312835590765 0.47250902361480246 0.18737650402422792 4.423035872801202 0.1826896619186808 0.1431513562223961 8.725028254767453e-08 7.059233157965376 -1.1043659620924937 EIAIVHS(ph)DAEKEQEEEEQKQEMEVK ddPTM_A459_Selumetinib_30min_R2 2 EIAIVHSDAEKEQEEEEQKQEMEVK 25 2 Q9H307 Q9H307 PNN Pinin 1 EIAIVHS(1)DAEKEQEEEEQKQEMEVK;EIAIVHS(1)DAEKEQEEEEQKQEMEVK 46.808 0.023147 16404900.0 58683.0 34193.0 43005.0 45033.0 47495.0 43381.0 68038.0 72157.0 53799.0 38343.0 True False 55421.6337866617 36815.49315217617 40238.105120303684 38899.427713741985 41528.25348931274 49356.338976490544 71201.90181473941 72366.96492376567 64560.303269655415 37235.93796292182 1.4883909690108663 0.9887086284448021 1.0806255279609531 1.0446743077205847 1.1152734632511487 1.325502771694318 1.912182308543957 1.9434709821416623 1.7338170273551912 1.0 15.184408078644235 -7.066077846653215 4.214976193827749 1.7228803917697446 1.1311213972007392 0.4123969401102736 0.2771784362833741 0.18505649467756632 6.421622715279382 0.10385155699105303 0.08128686831164308 8.588595583822939e-08 7.066077846653215 -0.5917589945690054 EIDCLS(ph)PEAQK ddPTM_A459_Selumetinib_30min_R1 3 EIDCLSPEAQK 11 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3;C9JTC6 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 EIDCLS(1)PEAQK;EIDCLS(1)PEAQK;EIDCLS(1)PEAQK 185.2 2.084e-05 103138000.0 13570.5 16537.1 18145.5 19379.6 16028.8 14204.800000000001 16265.399999999998 14473.5 8827.0 12488.8 True False 13886.666246403625 14600.928644110778 15681.440766096865 15995.316660146656 14578.997870114485 14061.912608926461 15038.487782651324 14089.61576344622 14978.774301427722 14091.859131213581 0.9854389060450192 1.0361250781857168 1.1128014139285813 1.135074975644406 1.0345688056036473 0.9978749062129929 1.0671755687183213 0.9998408039885672 1.0629381234907194 1.0 13.782574337715559 -6.496010131311716 24.78620725113273 1.0268304496987128 1.0704307142476979 0.16666175648287196 0.044263835227778735 1236.351134608621 1140531.3392638534 0.014511407843701208 0.01640123127578584 3.1914634031123946e-07 6.496010131311716 0.043600264548985024 EIDCLS(ph)PEAQK ddPTM_A459_Selumetinib_30min_R2 5 EIDCLSPEAQK 11 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3;C9JTC6 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 EIDCLS(1)PEAQK;EIDCLS(1)PEAQK;EIDCLS(1)PEAQK;EIDCLS(1)PEAQK;EIDCLS(1)PEAQK 124.38 0.0035905 147414600.0 178248.0 179150.0 184892.0 202246.0 190895.0 157519.0 189205.0 183028.0 149304.0 183872.0 True False 168341.68974327962 192890.22894195758 172996.25001518845 174699.7459061903 166913.06347704725 179215.8124348867 198003.40740259495 183560.5811780834 179168.97190231454 178563.1376031703 0.94275723423607 1.0802354367821823 0.968823982022799 0.9783640019500228 0.9347565556782857 1.0036551487640573 1.108870565674242 1.027986983438985 1.003392829602326 1.0 17.446074757101655 -7.010850697322697 24.768404237370294 1.0400902757288442 0.9840323361777927 0.22822267346052938 0.046347975067449566 685.5438240776209 1564859.8708012647 0.017156634623191787 0.014165372055355478 9.753248793428806e-08 7.010850697322697 -0.05605793955105143 EIDSELEAMT(ph)EK ddPTM_A459_Selumetinib_30min_R1 1 EIDSELEAMTEK 12 0 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2 Q8NF91 SYNE1 Nesprin-1 1 EIDSELEAMT(1)EK 123.67 0.033005 9025900.0 2101.7 2518.8 2526.3 2603.6 2386.1 2064.9 2608.6 2420.1 1268.7 2803.5 True False 2150.6655208036923 2223.897725041649 2183.242335972582 2148.9301356249794 2170.2776763001707 2044.128980779193 2411.831201804092 2355.911086407311 2152.8912378182126 3163.3565334025116 0.6798682026810404 0.7030183608957986 0.6901663827391227 0.6793196128650053 0.6860679956191396 0.6461898806520314 0.7624278756874497 0.7447504135340979 0.6805717961555725 1.0 11.627240451957183 -14.522878745280336 0.2983414705295436 3.4910066790408925 0.6821427150800787 0.8964764524430087 0.03100959360361308 78.43079976000956 0.7273904388643966 122.03358224602476 0.03208534823928996 3.0000000000000132e-15 14.522878745280336 -2.808863963960814 EIDTDSTS(ph)QGESK ddPTM_A459_Selumetinib_30min_R2 2 EIDTDSTSQGESK 13 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 EIDTDS(0.024)T(0.024)S(0.947)QGES(0.005)K;EIDTDS(0.141)T(0.141)S(0.718)QGESK 189.09 1.6483000000000004e-06 2904500.0 54465.0 44560.0 56963.0 57073.0 58896.0 43984.0 47983.0 48578.0 41948.0 54189.0 True False 51438.053340669845 47977.60871701722 53298.06259662504 49299.55894358347 51496.957943079564 50042.39675300158 50214.304576510716 48719.353937479194 50338.77212504888 52624.42277006939 0.977455915581571 0.911698526873057 1.0128008972088676 0.9368189967420039 0.9785752552210211 0.950934834414253 0.9542015272245523 0.9257936025321832 0.9565667322374795 1.0 15.683444883095218 EIEDFDSLEALR ddPTM_A459_Selumetinib_30min_R2 2 EIEDFDSLEALR 12 0 P46060;B0QYT5;B0QYT4 P46060 RANGAP1 Ran GTPase-activating protein 1 0 ; 128.51 0.033801 4499500.0 22946.3 17614.4 23670.6 23983.0 25058.0 21541.1 21991.1 24170.5 22551.0 18650.9 False True 21671.036507316854 18965.367840777126 22147.659366600637 20716.47402701737 21909.99001863773 24508.190994363453 23013.729724537963 24240.832153358308 27061.830127585996 18112.400056142153 1.1964751463165657 1.0470930291949752 1.222789873122865 1.1437729932423917 1.2096679595594382 1.3531167000726887 1.2706063058017374 1.3383556060058381 1.4941051458505619 1.0 14.144690108591508 -6.5722017914952175 4.03185637803785 1.3106906290833917 1.1518031312260526 0.2114135409120118 0.12356645311102588 0.29207584527159636 10.026178689606713 0.03967308800921588 0.04052170835996603 2.6779237596134717e-07 6.5722017914952175 -0.15888749785733913 EIEHVMYHDWR ddPTM_A459_Selumetinib_30min_R1 1 EIEHVMYHDWR 11 0 C9JJ19;P82930 C9JJ19 MRPS34 28S ribosomal protein S34, mitochondrial 0 132.17 0.0011634 3335100.0 1590.4 1736.3 1640.2 2178.9 1633.3 1682.3 1279.5 1555.1 922.45 1095.2 False True 1627.4532256203036 1533.013188816029 1417.4698489736884 1798.396018018615 1485.5683033825355 1665.3775894061876 1182.9862848686405 1513.8536963232966 1565.3302769176396 1235.7795881513925 1.3169445758970797 1.2405231511464512 1.1470248113533636 1.455272473555614 1.2021304750670003 1.3476331907192547 0.9572793532204835 1.225019178855249 1.2666743260092386 1.0 10.271205733861406 -7.230395064040083 24.998654802246186 1.1309947052767355 1.280615316151181 0.3391000297223047 0.11684016564984206 895.0081516456222 720712.7086176346 0.043865122367786925 0.03397443227495893 5.883082463492713e-08 7.230395064040083 0.14962061087444556 EIELTHR ddPTM_A459_Selumetinib_30min_R2 1 EIELTHR 7 0 O43395;O43395-3 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 0 116.9 0.016836 961610.0 5540.2 5500.2 5385.5 4729.4 7121.6 5081.2 6006.3 4345.7 6254.0 4800.9 False True 5232.297863177802 5922.047654069528 5039.002793289045 4085.247561329942 6226.920940088215 5781.08917745888 6285.604851257662 4358.345267530636 7504.974751360158 4662.285542763773 1.1222602766788345 1.2702026934538582 1.0808009820655378 0.876232809822333 1.3355940735446536 1.239968921773051 1.3481810141408874 0.9348087386657654 1.6097201002646562 1.0 12.186821650028476 -6.316310687228042 24.999719057801247 1.2463888352078538 1.099961787992609 0.13151018800687198 0.19699259398435773 674.4193401435532 307268.05960310163 0.058651727723541276 0.06650487115012928 4.82713353187054e-07 6.316310687228042 -0.1464270472152449 EIEMSVDDDDINS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 EIEMSVDDDDINSSK 15 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 EIEMS(0.038)VDDDDINS(0.908)S(0.054)K 119.96 0.0018468 6004300.0 576.91 982.57 611.93 707.48 719.47 604.84 834.46 727.96 675.85 792.36 True False 590.3508805285525 867.5302476155996 528.8332670908849 583.9318990443852 654.3940655327453 598.75585875078 771.5160103723994 708.6521360526697 1146.8680878690307 894.0671242399907 0.6602981638882933 0.9703189213595691 0.591491681947733 0.6531186341749916 0.7319294578570021 0.6696989996805414 0.8629285088949368 0.792616255356739 1.2827538970789645 1.0 9.804239339050014 -8.153864537294186 5.294595262968861 1.1372915038542761 0.7386293357033449 0.6313186464709881 0.12259006246771854 0.13426861499747944 5.320030109896528 0.08557279809104346 0.03087426068985553 7.016741265595095e-09 8.153864537294186 -0.39866216815093125 EIEMSVDDDDINS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 EIEMSVDDDDINSSK 15 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 EIEMSVDDDDINS(0.5)S(0.5)K 84.17 0.022096 3307000.0 18882.0 18155.0 17551.0 20513.0 19023.0 21134.0 20044.0 21010.0 13622.0 23685.0 True False 17832.614030634875 19547.430122474143 16421.787768083952 17719.09401310127 16633.16067222227 24045.01666464931 20976.0857164325 21071.135621607253 16346.780630480978 23001.152508979565 0.7752921956268534 0.8498456812041439 0.7139549968930012 0.770356789999275 0.7231446626741311 1.0453831239657327 0.9119580294180264 0.9160904269201797 0.7106939804037756 1.0 14.489418531037888 -6.73615117411924 24.999882209360827 0.9112766620823546 0.7684411135149022 0.4198327609333854 0.08821071857970646 241.64198022051252 238886.36837596062 0.02916556531324711 0.029155062918997242 1.8358991716292478e-07 6.73615117411924 -0.1428355485674524 EIEMSVDDDDINSS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 EIEMSVDDDDINSSK 15 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 EIEMSVDDDDINS(0.008)S(0.992)K 89.26 0.01678 17490000.0 1692.5 1890.2 1951.7 2224.8 1635.0 1605.8 1665.1 1965.6 898.52 1287.7 True False 1731.9319569682866 1668.894505269859 1686.6698599207111 1836.280444668327 1487.114538682695 1589.6471099497433 1539.5001664202987 1913.465902831375 1524.7228146956886 1452.9888382601791 1.191978844821765 1.1485941676387599 1.1608278160900007 1.2637952861820358 1.0234865537324969 1.0940532150633724 1.0595402565264775 1.3169171382779339 1.0493699432140198 1.0 10.504807905011686 -14.5228787452756 0.1935875632332833 0.3694472198033455 1.1716173437003699 0.21674874625250096 0.08804559014294729 234.7419158238564 2.299926392963465 57.304534192018 0.23027942803324453 3.000000000032727e-15 14.5228787452756 0.8021701238970244 EIEMSVDDDDINSS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 EIEMSVDDDDINSSK 15 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 EIEMSVDDDDINS(0.009)S(0.991)K;EIEMSVDDDDINS(0.008)S(0.992)K 94.781 0.011244 5928000.0 20365.2 20798.0 21833.6 23882.2 27715.9 20312.3 16527.1 18813.3 19183.3 20443.6 True False 19233.383712354895 22393.1397238897 20428.849946626277 20629.403160907088 24233.980858710256 23110.13494829923 17295.642897827376 18868.04358829052 23020.496026186014 19853.34014914818 0.9687731922116951 1.1279280743522893 1.028988059095073 1.0390897957688094 1.220650060727944 1.1640426635862975 0.871170431166438 0.9503712446643424 1.1595276086162116 1.0 14.277094128037456 -10.921751442837586 6.559525838429019 0.9999933149866074 1.0586430505861317 0.027999671007222893 0.10418280330795947 1.0665105164063149e-05 9.771759570128915e-07 0.10562527075163905 0.025614971413790207 1.1974256506917845e-11 10.921751442837586 0.058649735599524355 EIEQEAAVELSQLRDPQHDLDR ddPTM_A459_Selumetinib_30min_R1 2 EIEQEAAVELSQLRDPQHDLDR 22 1 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 0 ; 104.68 5.4155e-05 8246100.0 2510.2 2570.1 2802.3999999999996 3219.7 2081.75 2896.8 1830.85 2426.5 785.25 1042.99 False True 2568.682776001059 2269.1914971929264 2421.8494724813236 2657.4398362543207 1893.4560800628137 2867.660822083956 1692.7475104742084 2362.1413376171804 1332.5118976091683 1176.8679260829263 2.182643199862395 1.9281615607842058 2.0578770300437874 2.2580612296056985 1.6088942846500807 2.4366887384114935 1.4383495997790763 2.0071422504301775 1.1322527091415309 1.0 10.200736707777105 -8.243177036028616 1.0277140454727844 0.9644595306219369 2.0461156703716767 0.6205206572646491 0.2849971869851344 0.3089632694224918 0.6648065270921176 0.2454968985292032 0.08439390546075229 5.71245726298087e-09 8.243177036028616 1.08165613974974 EIES(ph)SPQYR ddPTM_A459_Selumetinib_30min_R1 1 EIESSPQYR 9 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EIES(0.5)S(0.5)PQY(0.001)R 86.189 0.034176 23897000.0 4362.4 5094.8 4597.3 5229.4 6846.8 4390.4 5043.7 4280.3 2714.1 3482.3 True False 4464.035432247242 4498.298447491738 3973.011911161286 4316.183457995571 6227.508148900722 4346.23656216425 4663.249648293834 4166.772539626134 4605.6294699790415 3929.2871254744296 1.1360929577545815 1.1448128639743032 1.0111279181924322 1.0984647647693668 1.584895160378182 1.1061132524489357 1.1867927945659569 1.06043982192394 1.1721285115866784 1.0 11.940051878613685 -8.776509326343565 0.88651706640867 1.0035713758833689 1.178538186865195 0.10387242295813304 0.14834966499212782 2.4263784853496815 3.724349952292781 0.1509228659654695 0.0511580567770415 1.6729797092760839e-09 8.776509326343565 0.1749668109818261 EIES(ph)SPQYR ddPTM_A459_Selumetinib_30min_R2 4 EIESSPQYR 9 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EIES(0.5)S(0.5)PQYR;EIES(0.5)S(0.5)PQYR;EIES(0.5)S(0.5)PQYR;EIES(0.62)S(0.38)PQYR 123.62 0.0055697 230459000.0 445161.0 472855.0 541844.0 586362.0 625650.0 452856.0 457463.0 455718.0 438933.0 501891.0 True False 420420.73374067637 509121.4580315343 506982.34695514175 506498.48406913015 547050.2536180344 515232.80338253174 478735.93594573747 457044.0639318235 526731.8648127236 487400.10276057606 0.8625782624161618 1.0445657584968304 1.040176938994584 1.0391841963109634 1.122384362497273 1.057104420914798 0.9822237074515049 0.9377184398262954 1.0806970737785593 1.0 18.89474702966745 -4.7593129117874575 24.973821823609107 1.0340924070684845 0.862578039605895 0.5255940435636048 0.048795753253696825 48.32755530374346 567432.5167494152 0.013003423195732219 0.08351001112855916 1.740552343061095e-05 4.7593129117874575 -0.17151436746258952 EIESEIDS(ph)EEELINK ddPTM_A459_Selumetinib_30min_R1 2 EIESEIDSEEELINK 15 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 EIESEIDS(1)EEELINK;EIESEIDS(1)EEELINK 284.74 1.1244e-55 8528900.0 1915.1799999999998 2069.3599999999997 2244.17 2282.6 1982.7199999999998 1823.8200000000002 1870.87 1709.98 1106.93 1419.67 True False 1959.7999677084347 1827.078369180635 1939.4240403434237 1883.9867597087025 1803.383326077647 1805.474026696066 1729.7487696539213 1664.6257756021541 1878.37936303154 1601.8984732568374 1.2234233320192534 1.1405706414501924 1.2107034701146568 1.1760962327895528 1.1257787907189702 1.127083929997971 1.079811734970413 1.0391581010860103 1.1725957633336064 1.0 10.645566998719316 -6.677765638364965 0.9519646268141758 1.0717470969382266 1.1920407538049804 0.5489721044806546 0.04603531493898573 0.43362103587088635 0.8528894018993367 0.025163844825984265 0.025197769648289254 2.100072856189789e-07 6.677765638364965 0.12029365686675386 EIEVGGGRK ddPTM_A459_Selumetinib_30min_R1 1 EIEVGGGRK 9 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 90.601 0.038328 2885700.0 1967.4 1908.6 2110.7 2166.8 2123.0 2023.0 1875.8 1786.9 1460.9 1356.8 False True 2013.2365921060016 1685.1402247159313 1824.0785332451926 1788.409055873485 1930.9750248460932 2002.6504567370368 1734.3068957847554 1739.5056073307808 2479.040600085619 1530.9584963511782 1.3150170934772332 1.1007092803183256 1.191461778743594 1.168162990790347 1.261285024674606 1.3081023825989204 1.1328242404469024 1.1362199638178598 1.6192735505201872 1.0 10.580219457166706 -6.2644486806492985 24.291043061385153 1.2475131047157246 1.1870160345657048 0.02118693417350037 0.1590840412467821 793.4256449835873 6404519.161806618 0.046929591783317834 0.05560871379333934 5.439404038221128e-07 6.2644486806492985 -0.060497070150019816 EIFMQVEDERR ddPTM_A459_Selumetinib_30min_R1 1 EIFMQVEDERR 11 1 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 0 121.61 0.0042232 0.0 1341.9 1677.2 1630.3 1610.8 1844.9 1427.3 1689.4 1794.2 855.65 1146.6 False True 1373.1636591171325 1480.832644290874 1408.914214596882 1329.5040184608688 1678.0291207435496 1412.9426578847113 1561.967197856256 1746.6119876170399 1451.9755557966057 1293.7772788297912 1.0613601595779651 1.1445808088624594 1.088992856538052 1.0276142889627742 1.2969999923490003 1.0921065634749003 1.2072921849957359 1.3500097862259826 1.1222762832176982 1.0 10.33737356630212 -6.245336516805267 24.8325577869492 1.1927731555089771 1.0858012894480584 0.18310338111852686 0.09772961771894213 1176.6009093650425 1814459.3734065301 0.027893079717196092 0.0359011825490003 5.684123209971941e-07 6.245336516805267 -0.10697186606091869 EIFSGS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 EIFSGSLR 8 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 EIFS(0.001)GS(0.999)LR 81.525 0.045519 0.0 4608.8 4608.4 7308.6 9054.7 8192.2 7554.2 6025.5 7096.8 6308.8 4752.1 True False 4352.661346488192 4961.849461658487 6838.372633002015 7821.434239771261 7163.022596802779 8594.722479800028 6305.697689301743 7117.45051306151 7570.736282600087 4614.894525561401 0.9431767773627918 1.0751815527257103 1.4818047509265944 1.6948240520881213 1.5521530464298963 1.8623876303553182 1.3663795899072375 1.5422780463645969 1.6405003929486577 1.0 12.172081959794587 -5.234208561809852 3.113454600505454 1.5569146258626592 0.9680785514296627 0.4692960565552381 0.2162850724401704 0.19374828638684347 3.7836746070619323 0.05421220427657553 0.1653072337692773 5.831649829313823e-06 5.234208561809852 -0.5888360744329965 EIHQDWANR ddPTM_A459_Selumetinib_30min_R1 3 EIHQDWANR 9 0 Q8WUW1;Q8WUW1-2 Q8WUW1 BRK1 Protein BRICK1 0 ;; 114.97 0.011684 18564500.0 7004.5 8243.1 8676.1 8827.9 8915.0 7157.1 7372.0 7624.3 4162.6 6188.5 False True 7167.6912216155815 7277.994019886774 7497.9332744059375 7286.27298520654 8108.63982407109 7085.106072126862 6815.924104768753 7422.078796783296 7063.6281757248325 6982.854256094679 1.0264701164798873 1.0422663502584915 1.0737633923637593 1.0434519636217576 1.1612214041262308 1.0146432693970289 0.9760942810484369 1.0629004307665821 1.011567464630907 1.0 12.769601146228045 EIHQDWANR ddPTM_A459_Selumetinib_30min_R2 1 EIHQDWANR 9 0 Q8WUW1;Q8WUW1-2 Q8WUW1 BRK1 Protein BRICK1 0 109.44 0.016059999999999998 3885200.0 38410.0 31884.0 45300.0 40899.0 50440.0 34692.0 37477.0 32822.0 43935.0 35559.0 False True 36275.325967412646 34329.400276781365 42385.44731891076 35328.48564528973 44103.27626067873 39470.50809737928 39219.75475926665 32917.50658602541 52723.227646467625 34532.31927662252 1.0504746488884138 0.9941237946337846 1.2274138606034668 1.023055687696198 1.2771594026855735 1.143001944966372 1.1357405346885405 0.9532376415941951 1.5267792245324188 1.0 15.075659611989115 -5.249837067749838 24.42249195746478 1.1568342899149433 1.0222992073163248 0.11193974262041106 0.15572031565014857 1199.1456013437255 2524147.183779806 0.03698014694240272 0.09604775504049655 5.625523357613548e-06 5.249837067749838 -0.13453508259861846 EIHQFNR ddPTM_A459_Selumetinib_30min_R1 1 EIHQFNR 7 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 91.041 0.040545 3991000.0 3910.0 3733.8 3975.6 4249.1 4402.6 3522.1 3433.3 4298.8 2100.1 3257.7 False True 4001.095392464405 3296.6449602034713 3435.735356407633 3507.0744504855197 4004.3856073421616 3486.6708718109307 3174.3234168343124 4184.781859529669 3563.716314764739 3675.8575276851666 1.0884794533873172 0.8968369789564449 0.9346758764535827 0.9540833462862919 1.0893745410921523 0.9485326472940385 0.8635599701366309 1.1384505052253733 0.9694925028851574 1.0 11.843865135052539 -7.76419018106366 24.9993240912328 1.0404785821009037 0.9673127697925482 0.13262033095256065 0.07948639400565966 142.91698893273895 1298779.4696819196 0.04055003009988496 0.020844024259062687 1.72111471989228e-08 7.76419018106366 -0.0731658123083555 EIHQFNR ddPTM_A459_Selumetinib_30min_R2 2 EIHQFNR 7 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 ; 105.12 0.024849 19766900.0 39000.0 32667.0 42222.0 38227.0 38424.0 29156.0 29603.0 29658.0 24847.0 37610.0 False True 36832.53612936978 35172.45385903957 39505.48248783776 33020.41665474681 33596.83360508164 33171.97434818374 30979.59815723166 29744.299869853796 29817.094283186078 36524.101577484565 1.008444685524458 0.9629929920226094 1.081627768557929 0.9040719751776833 0.9198537993825029 0.9082215007482277 0.8481960354728934 0.8143745796663153 0.8163676311087402 1.0 15.156561165496802 -6.251805412581706 1.2399788788080208 0.8609185059668668 1.0108346450692685 0.4526267115479169 0.061557531825463564 0.3809837415060235 1.1976121508104158 0.024345413432382834 0.03553118237967033 5.600084593718641e-07 6.251805412581706 0.14991613910240165 EIIDLVLDR ddPTM_A459_Selumetinib_30min_R1 1 EIIDLVLDR 9 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;P68363 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 139.96 0.032333 19413000.0 5284.1 5903.3 4523.9 4462.0 5712.1 4269.4 4413.5 4530.0 3462.6 5010.1 False True 5407.209248931244 5212.138891630286 3909.5792280039464 3682.795462113482 5195.441563553167 4226.453712305042 4080.5861416707626 4409.849684486228 5875.779301702012 5653.195137506659 0.9564872815121136 0.9219810682015656 0.6915698349178631 0.6514538013520224 0.9190274591944504 0.7476221162549713 0.721819438815711 0.7800632345465421 1.039373161332889 1.0 12.464850781594256 -8.260571777165781 24.999999980713373 1.0196866058254919 0.7941182100106046 0.4440962528269914 0.09876533696140889 72.36580781149594 2085390.2535328749 0.08094224149051361 0.02653094603526808 5.488178433221526e-09 8.260571777165781 -0.2255683958148873 EIIDLVLDR ddPTM_A459_Selumetinib_30min_R2 1 EIIDLVLDR 9 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;P68363 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 136.57 0.036411 3764400.0 21880.0 18914.0 22086.0 25569.0 29334.0 21055.0 20441.0 25585.0 21491.0 23109.0 False True 20663.99719257976 20364.642981904497 20665.01080541861 22086.458091014767 25648.800670712695 23955.135131739913 21391.547003073076 25659.448114175248 25789.80050871141 22441.783125607293 0.9207823227291159 0.9074431772164901 0.9208274890527175 0.9841668091789426 1.1429038649538512 1.0674345704912283 0.9532017524340194 1.1433783122561425 1.149186780941834 1.0 14.453899690267464 -6.007212427778803 3.878213629629498 1.0765837559859417 0.9175304143196995 0.5927644013154045 0.059778637617698874 0.15952784010676432 5.395300020812733 0.018482092636035792 0.026502347979177103 9.835299111144125e-07 6.007212427778803 -0.1590533416662422 EIIKQEES(ph)VDPDYWEK ddPTM_A459_Selumetinib_30min_R1 1 EIIKQEESVDPDYWEK 16 1 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8Y5Z7;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 EIIKQEES(0.998)VDPDY(0.002)WEK 103.31 0.0024601 8596800.0 2509.6 4929.7 4478.7 4584.7 3838.8 4448.7 4558.7 4844.8 2576.2 3068.9 True False 2568.0687971684574 4352.528432244649 3870.517139738119 3784.0682104777393 3491.5812177951884 4403.950117096419 4214.833588769575 4716.300165871714 4371.6232417965475 3462.8232086174307 0.7416112929986357 1.256930593919186 1.1177345496894324 1.092769680259989 1.0083047870033306 1.2717802358887225 1.2171668418649626 1.3619812164060052 1.2624448256317322 1.0 11.757733018555408 -6.766623821626856 24.992177908935044 1.244954237206339 1.0621937464693474 0.2542096257615081 0.14937029641445151 175.86212339609745 847756.3601416661 0.04987487669641948 0.04531216399922158 1.711497142471403e-07 6.766623821626856 -0.18276049073699152 EILDAFDK ddPTM_A459_Selumetinib_30min_R2 1 EILDAFDK 8 0 A0A0J9YXB8;C9JIZ6;P07602;P07602-2;P07602-3 A0A0J9YXB8 PSAP Prosaposin;Saposin-A;Saposin-B-Val;Saposin-B;Saposin-C;Saposin-D 0 149.65 0.019327 3580700.0 31688.0 26182.0 24396.0 33483.0 24360.0 23312.0 29726.0 30263.0 22746.0 19912.0 False True 29926.907817114585 28190.075211601106 22826.38792035643 28922.5576386033 21299.679018836894 26523.016394733815 31108.317900951555 30351.060319690656 27295.835576341226 19337.088822410853 1.547642879026888 1.4578241570121984 1.1804459363035882 1.4957038209951903 1.1014935709532183 1.3716137231574788 1.6087384293802465 1.5695775407782728 1.4115793657991853 1.0 14.239082994550168 -7.021306616853125 24.662402803408092 1.4514011247448562 1.347820619227294 0.0 0.20165810051671526 2179.0708969848397 2522268.057277395 0.07422276555173823 0.05811187197122771 9.52123716480231e-08 7.021306616853125 -0.10358050551756226 EILDESLR ddPTM_A459_Selumetinib_30min_R2 1 EILDESLR 8 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 148.04 0.022485 1574300.0 14488.0 12679.0 14150.0 13954.0 14582.0 10436.0 12754.0 11125.0 9997.9 15618.0 False True 13682.814960059213 13651.438530589356 13239.60440535513 12053.441128007355 12750.078795265992 11873.464271424245 13347.086271571556 11157.37190815711 11997.759364666408 15167.067759562718 0.9021397660356798 0.9000710451749798 0.8729178648923529 0.7947113653796235 0.8406423045896374 0.7828450732632957 0.8800043939380651 0.7356314407656335 0.7910401374123165 1.0 13.888654576694401 -5.581210557011486 4.688704184119633 0.8215631981565767 0.8983644894012045 0.1338500458845071 0.0679847759561128 0.31328154549060316 14.061181688783519 0.01750897283795674 0.03186224394539292 2.6229465638542483e-06 5.581210557011486 0.07680129124462776 EILGT(ph)AQSVGCNVDGR ddPTM_A459_Selumetinib_30min_R2 1 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 1 EILGT(0.998)AQS(0.002)VGCNVDGR 104.44 0.0090442 2265300.0 10033.0 7376.8 9051.9 10581.0 9498.2 8244.1 4366.5 9085.7 7616.6 10066.0 True False 9475.406025281209 7942.576839849481 8469.510608963541 9139.849546756908 8304.951201014639 9379.649942511373 4569.550902055603 9112.13788278139 9140.132825585188 9775.36842539111 0.9693144660071571 0.8125092062227517 0.8664134424810365 0.9349877313080631 0.8495793549267029 0.9595188165131582 0.46745561938989283 0.9321528853186744 0.9350167101471157 1.0 13.254935362066036 EILGTAQS(ph)VGCNVDGR ddPTM_A459_Selumetinib_30min_R2 2 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 1 EILGTAQS(1)VGCNVDGR;EILGT(0.002)AQS(0.998)VGCNVDGR 203.92 3.031e-07 5518000.0 14495.1 17103.3 20906.7 24827.0 24653.0 15199.300000000001 14599.5 21373.4 18170.6 19427.2 True False 13689.520370482756 18415.068114222646 19561.58568349386 21445.51977103618 21555.86973938366 17292.865609492004 15278.405678360426 21435.59305544317 21805.227728983813 18866.286258072538 0.7256075829245547 0.9760833617343835 1.0368540695243516 1.1367112465952347 1.142560302781386 0.9166014642703041 0.809825816770011 1.136185084983075 1.1557774238506402 1.0 14.203522842532525 -4.745845522579395 2.645099822603197 1.0402994571549664 0.6445074321338529 0.44371732204371206 0.10601433132421245 0.5710412643932763 4.843763953006979 0.030057640313785817 0.5276297163231206 1.7953721224767434e-05 4.745845522579395 -0.39579202502111355 EILGTAQSVGCNVDGR ddPTM_A459_Selumetinib_30min_R2 1 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 219.84 1.2537e-09 6202100.0 25308.0 23459.0 29129.0 27546.0 28631.0 18344.0 22369.0 21638.0 17098.0 27365.0 False True 23901.482675951043 25258.2298674261 27254.8718532572 23794.187280499555 25034.117815612448 20870.71948974764 23409.202823332605 21700.96299763627 20518.077758035815 26574.901347191317 0.8994006172849697 0.9504543229506899 1.0255869437550236 0.8953631462121814 0.9420211006073326 0.7853545425090902 0.8808763772064466 0.8165961827711481 0.7720848137863119 1.0 14.697776715663984 -6.73710310068739 23.08585413162206 0.841388060299724 0.9449936300028947 0.30643556620644374 0.06808102146873218 105.20569791268922 99799.19293297389 0.0215292339600644 0.021514017346851405 1.8318794860265715e-07 6.73710310068739 0.1036055697031707 EILS(ph)PLFPR ddPTM_A459_Selumetinib_30min_R1 2 EILSPLFPR 9 0 A0A2R8YH03;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 1 EILS(1)PLFPR;EILS(1)PLFPR 101.97 0.012993 0.0 2188.76 2694.74 2339.3900000000003 2647.1 2058.5299999999997 2275.79 1974.4299999999998 2066.48 1181.55 1919.35 True False 2239.753849414422 2379.23858804936 2021.7136873494449 2184.83367722111 1872.33632496299 2252.897618851993 1825.4971554772883 2011.6702375269524 2005.0040530023718 2165.717268552206 1.0341857092508246 1.098591502500183 0.9335076728187016 1.0088268256186939 0.8645340516745554 1.0402547237193465 0.842906496607308 0.9288702023749227 0.9257921530739459 1.0 11.080629198023118 -5.268730410997048 24.591674971541504 0.9399810194806608 1.06638860844561 0.40278503073130956 0.05996105501136067 361.50200319604426 1219303.197562831 0.014792825216977178 0.03186620515725654 5.386040180833794e-06 5.268730410997048 0.1264075889649492 EILS(ph)PLFPR ddPTM_A459_Selumetinib_30min_R2 1 EILSPLFPR 9 0 A0A2R8YH03;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 1 EILS(1)PLFPR 103.31 0.015352 1239500.0 5653.5 4484.2 5744.5 5743.9 5997.7 3698.9 4488.7 4696.1 2953.1 4606.8 True False 5339.30110275364 4828.123721024433 5374.905124138695 4961.570911219826 5244.215305881691 4208.3898997289325 4697.433444190314 4709.764873518797 3543.802516508101 4473.789714096141 1.1934626891224729 1.0792022042993763 1.2014210473959681 1.1090308727714155 1.1722087181161134 0.9406767346415547 1.0499897725164662 1.0527461446565398 0.7921254111122364 1.0 12.127281730249877 -7.023265714221384 0.8699775532939785 0.9386552604769675 1.1574546205037048 0.5337526551362051 0.08162950954445307 0.48327805726274736 0.7561125211724918 0.0565301756399589 0.0407321558056851 9.478383702841109e-08 7.023265714221384 0.2187993600267374 EILSEVER ddPTM_A459_Selumetinib_30min_R2 1 EILSEVER 8 0 B4DUR8;P49368-2;P49368 B4DUR8 CCT3 T-complex protein 1 subunit gamma 0 157.33 0.0075260000000000014 6098900.0 26731.0 23915.0 28711.0 30881.0 27883.0 23321.0 24736.0 26973.0 27816.0 26533.0 False True 25245.39803267136 25749.203601155015 26863.765518173215 26674.95452730367 24380.088262817306 26533.25606303993 25886.273013454145 27051.48696437948 33379.9772439773 25766.92334898691 0.9797598918096655 0.9993123064173437 1.0425678360714892 1.0352401862658727 0.9461776997049152 1.0297409474803731 1.004631894264238 1.0498532012531903 1.2954583980353136 1.0 14.653232664742944 -8.0169436036091 23.77146537372362 1.1560381176751502 1.0078505647021143 0.3823145235500136 0.07134176040538912 338.6628515754932 475131.2595243923 0.04188715194301205 0.016732278830128677 9.61737159047682e-09 8.0169436036091 -0.14818755297303587 EIPFNEDPNPNTHS(ph)SGPSTPLK ddPTM_A459_Selumetinib_30min_R1 1 EIPFNEDPNPNTHSSGPSTPLK 22 0 Q86YS7-3;Q86YS7;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 EIPFNEDPNPNT(0.005)HS(0.511)S(0.475)GPS(0.001)T(0.007)PLK 147.22 2.5908e-07 18404000.0 3112.0 3937.9 4513.2 4778.9 4439.3 3408.7 3490.2 3019.5 1442.9 2733.5 True False 3184.503545102106 3476.8488373199552 3900.3322292330517 3944.354826063225 4037.766098822072 3374.4115728519682 3226.9314040238605 2939.413051281712 2448.4959147536047 3084.3713515447703 1.032464376738289 1.1272471570515066 1.26454689941262 1.2788196933834646 1.309105045603476 1.0940354413426694 1.0462201324777871 0.9530023191953012 0.7938395334684019 1.0 11.590760757690452 -7.442124190502201 1.691238037316403 0.898965882632797 1.2023102819246165 0.6404412981101415 0.09198765729310536 0.24801153415657862 1.3797868370335034 0.060549279604396065 0.03178672837777556 3.613065289400756e-08 7.442124190502201 0.30334439929181956 EIPFNEDPNPNTHS(ph)SGPSTPLK ddPTM_A459_Selumetinib_30min_R2 1 EIPFNEDPNPNTHSSGPSTPLK 22 0 Q86YS7-3;Q86YS7;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 EIPFNEDPNPNT(0.001)HS(0.566)S(0.354)GPS(0.031)T(0.049)PLK 128.19 1.8132e-05 14754000.0 67050.0 72459.0 79945.0 89457.0 84798.0 61934.0 57795.0 75483.0 51591.0 65169.0 True False 63323.62942241645 78016.37230759337 74801.42573753465 77272.80227806733 74144.9171362615 70464.84631912522 60482.582018619876 75702.64303311674 61910.64157298079 63287.401640603326 1.0005724327571364 1.232731480281541 1.1819323245772864 1.2209823799827388 1.1715588760827291 1.113410323262775 0.9556812327687039 1.1961723987819426 0.9782459062636054 1.0 15.94963071649257 -6.999480206956058 5.487160353525852 1.0466038589215811 1.1681342762149955 0.3308510964067586 0.08532165243099323 0.20485224098988783 20.930790756321805 0.030443920274956265 0.02538018588391527 1.0011975842464224e-07 6.999480206956058 0.1215304172934144 EIPFNEDPNPNTHSS(ph)GPSTPLK ddPTM_A459_Selumetinib_30min_R2 1 EIPFNEDPNPNTHSSGPSTPLK 22 0 Q86YS7-3;Q86YS7;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 EIPFNEDPNPNTHS(0.172)S(0.458)GPS(0.185)T(0.185)PLK 102.69 6.4785e-05 15861000.0 48820.0 43973.0 50287.0 58511.0 55338.0 36120.0 45433.0 37636.0 27923.0 35884.0 True False 46106.77984194444 47345.58770451973 47051.5891683458 50541.700862895144 48385.945712003144 41095.20213528594 47545.7245237816 37745.5145290248 33508.38023380708 34847.93568217111 1.3230849672835447 1.3586339270231913 1.3501973143395785 1.4503499238479505 1.3884881490055763 1.1792722102707234 1.3643770740803716 1.0831492250582908 0.961559977021842 1.0 15.088785575978775 -7.868882837959458 3.1031020309625483 0.9853212204249412 1.3469381706137953 0.84151527990748 0.06637145321325548 0.09964425803947821 1.8727191686701665 0.045568447015088276 0.019276228142195876 1.3524373685435842e-08 7.868882837959458 0.3616169501888541 EIPS(ph)ATQS(ph)PISK ddPTM_A459_Selumetinib_30min_R2 1 EIPSATQSPISK 12 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 2 EIPS(1)AT(0.029)QS(0.954)PIS(0.018)K 141.06 0.018619 12915000.0 66543.0 52498.0 64543.0 70671.0 66457.0 50800.0 62071.0 59303.0 56174.0 63037.0 True False 62844.806452734636 56524.4277923243 60390.37364910504 61045.48788572504 58108.07752688197 57797.23888351399 64957.42449135312 59475.56191185981 67410.36963269982 61216.958020204576 1.026591462319849 0.9233459097014994 0.9864974608698014 0.997198976557722 0.9492153711346368 0.9441377153114678 1.0611018023782561 0.9715536974612489 1.101171502354807 1.0 15.901643736106555 -7.259005689086186 24.993738787371257 1.0310862255162643 0.9698735637708734 0.3424778711997001 0.04221045813107744 248.10498972842498 2548036.345931877 0.01569725804019437 0.011566363789949529 5.5080048108938446e-08 7.259005689086186 -0.06121266174539086 EIPSATQS(ph)PISK ddPTM_A459_Selumetinib_30min_R1 4 EIPSATQSPISK 12 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 EIPS(0.001)AT(0.001)QS(0.995)PIS(0.003)K;EIPSAT(0.009)QS(0.991)PISK;EIPS(0.001)AT(0.009)QS(0.99)PISK;EIPSAT(0.008)QS(0.987)PIS(0.004)K 238.07 3.3434e-13 1169360000.0 32032.2 39196.899999999994 40805.6 41606.2 35209.0 32571.2 33515.6 31925.0 17174.5 26417.9 True False 32778.48793618884 34607.70872585557 35264.42364911645 34340.45821510219 32024.35216665382 32243.563300283415 30987.491308435638 31078.245292985164 29143.872124149817 29808.89479713721 1.099621041278485 1.1609859728573106 1.183016810556263 1.1520205109516566 1.074322023160999 1.0816759064606456 1.0395384169496824 1.0425829439328915 0.9776904619405326 1.0 14.863455266108069 -6.981662338707437 0.8311082270417495 0.9988694398514136 1.1545111500816472 0.827657749512559 0.02711780497059477 0.254234858921128 0.367390636197278 0.020425789712754862 0.015515332770612249 1.0431281399138971e-07 6.981662338707437 0.15564171023023354 EIPSATQS(ph)PISK ddPTM_A459_Selumetinib_30min_R2 5 EIPSATQSPISK 12 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 EIPS(0.001)AT(0.005)QS(0.946)PIS(0.049)K;EIPS(0.003)AT(0.046)QS(0.948)PIS(0.003)K;EIPS(0.001)AT(0.009)QS(0.986)PIS(0.003)K;EIPS(0.004)AT(0.003)QS(0.989)PIS(0.004)K;EIPS(0.026)AT(0.091)QS(0.861)PIS(0.023)K 209.56 6.9526e-06 1416922300.0 720344.0 586414.0 671186.0 756244.0 764419.0 583602.0 705323.0 684928.0 580923.0 620345.0 True False 680310.1642455069 631390.0681817994 628002.6234920635 653242.2626063349 668385.8512274333 663987.8780885139 738121.9170710105 686921.027084066 697123.8323448021 602434.0280001236 1.129269152514352 1.0480650807156429 1.042442150183347 1.0843382548872238 1.1094755942758536 1.1021752544303118 1.2252327769753057 1.1402427405444053 1.1571787115993706 1.0 19.20044373621382 -6.592520373209565 1.9082178805814087 1.1416373010705256 1.0718143164229992 0.11649782462751646 0.057660393851842316 0.5132703351000099 3.80905201667412 0.021383319503655056 0.0220932098828695 2.5555220160345975e-07 6.592520373209565 -0.06982298464752645 EIPSATQS(ph)PISKK ddPTM_A459_Selumetinib_30min_R1 1 EIPSATQSPISKK 13 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 EIPSAT(0.016)QS(0.977)PIS(0.007)KK 220.25 2.2261000000000003e-08 9023500.0 3578.2 3641.5 7260.5 8107.4 5210.0 4538.2 3586.2 3894.7 2602.5 3142.7 True False 3661.5650980348173 3215.1514871125796 6274.563979071741 6691.594784746487 4738.756419900211 4492.549828355913 3315.690046733815 3791.399904231459 4416.2524209205485 3546.0961574903076 1.032562270005174 0.9066735204913482 1.769428605543642 1.8870313966563037 1.336330491177089 1.2669001710138177 0.9350254193559266 1.0691757177038204 1.2453842831058703 1.0 11.792015942177176 -6.979358511330515 3.253477300003256 1.069036864332549 1.4074174133666415 0.21996481817726798 0.28518732581113626 0.4314441644914188 9.503816126327932 0.12508651193867984 0.10322332586954885 1.0486763859007508e-07 6.979358511330515 0.33838054903409254 EIQNGNLHES(ph)DSESVPR ddPTM_A459_Selumetinib_30min_R1 5 EIQNGNLHESDSESVPR 17 0 Q86UP2-2;Q86UP2-3;Q86UP2-4;Q86UP2 Q86UP2-2 KTN1 Kinectin 1 EIQNGNLHES(0.746)DS(0.245)ES(0.009)VPR;EIQNGNLHES(0.994)DS(0.005)ES(0.001)VPR;EIQNGNLHES(0.942)DS(0.045)ES(0.013)VPR;EIQNGNLHES(0.999)DSESVPR;EIQNGNLHES(0.988)DS(0.012)ESVPR 338.14 1.516299999999999e-154 94358500.0 10451.8 13717.599999999999 12270.6 11505.900000000001 13381.900000000001 12662.699999999999 13063.100000000002 13190.5 5914.719999999999 11585.0 True False 10695.306604337453 12111.537014860776 10604.319917581113 9496.610557492497 12171.50950776633 12535.3247348117 12077.739849837855 12840.645091217566 10036.8478459432 13072.047597456076 0.8181814306137353 0.9265217958063263 0.8112210301043272 0.7264822505190857 0.9311096381055867 0.9589411789818738 0.9239363427798625 0.9822979143463689 0.7678099219816528 1.0 13.674197521243054 -6.336657341143345 24.998108822096693 0.9278732285496705 0.8274965224852503 0.3299924551285719 0.07425451878179215 163.15872234101087 54223.503788079965 0.022922535759746322 0.025991714724761156 4.606198598566613e-07 6.336657341143345 -0.10037670606442017 EIQNGNLHES(ph)DSESVPR ddPTM_A459_Selumetinib_30min_R2 3 EIQNGNLHESDSESVPR 17 0 Q86UP2-2;Q86UP2-3;Q86UP2-4;Q86UP2 Q86UP2-2 KTN1 Kinectin 1 EIQNGNLHES(0.938)DS(0.052)ES(0.009)VPR;EIQNGNLHES(0.99)DS(0.008)ES(0.002)VPR;EIQNGNLHES(0.998)DS(0.002)ESVPR 176.46 9.3521e-08 98862000.0 212088.0 74850.0 160024.0 192668.0 118205.0 105976.0 241555.0 155587.0 162486.0 139254.0 True False 200300.99801553297 80590.75431931655 149728.2300609577 166426.28602916197 103355.03113389233 120573.23204565496 252787.78613215187 156039.73241118563 194987.74023816883 135233.37519465666 1.4811506237067376 0.5959383488233816 1.1071840057636433 1.2306598558943445 0.7642716229268239 0.8915937494875086 1.8692707016170074 1.1538551943008153 1.441861078727799 1.0 17.04509172284437 EIQNGNLHESDS(ph)ESVPR ddPTM_A459_Selumetinib_30min_R2 1 EIQNGNLHESDSESVPR 17 0 Q86UP2-2;Q86UP2-3;Q86UP2-4;Q86UP2 Q86UP2-2 KTN1 Kinectin 1 EIQNGNLHES(0.303)DS(0.677)ES(0.021)VPR 71.89399999999998 0.018954 73502000.0 170370.0 102810.0 154530.0 192820.0 143540.0 122000.0 143560.0 122890.0 108690.0 146030.0 True False 160901.51744514683 110695.19641374667 144587.70803954272 166557.5833669468 125507.22193611844 138804.39259426587 150235.8244587435 123247.58955446535 130431.03705234043 141813.73446849428 1.1345975624165876 0.7805675298561369 1.0195606834658508 1.1744813292675096 0.8850145749740584 0.9787796161950945 1.059388394373891 0.8690807700423852 0.919734872938681 1.0 17.1136377368453 -7.766059284829898 24.999182567380604 0.9208058805832805 0.9975220300436382 0.08341167785075043 0.11110547553626585 310.2953728586541 1679023.5786286423 0.05768006289489877 0.02915301519541266 1.7137233539664035e-08 7.766059284829898 0.07671614946035765 EIQSTLEGDRGS(ph)GNWR ddPTM_A459_Selumetinib_30min_R1 2 EIQSTLEGDRGSGNWR 16 1 J3QRV5;Q6P1M3 J3QRV5 LLGL2 Lethal(2) giant larvae protein homolog 2 1 EIQSTLEGDRGS(1)GNWR;EIQSTLEGDRGS(1)GNWR 198.67 4.11e-06 25259000.0 3510.7 3624.6 4323.2 4155.3 3654.7 3525.7 3589.6 3347.0 2060.71 2924.1 True False 3592.4924793669506 3200.2301469691765 3736.133185637758 3429.6548596414486 3324.1330302896927 3490.23465907947 3318.833581996462 3258.22668741179 3496.874361696514 3299.4367181459893 1.0888199369332454 0.9699322703686953 1.1323548547211282 1.0394667795200603 1.0074850085797618 1.0578274285074616 1.0058788409984636 0.9875099799588349 1.0598398030987144 1.0 11.688004032375302 -5.9988558201884805 24.999535569894142 1.0206268694932066 1.059589583172657 0.16761007938023553 0.04361373268471472 77.20095394634512 1686680.383265985 0.011874291347202028 0.017444715045014863 1.0026380449106353e-06 5.9988558201884805 0.03896271367945037 EIQSTLEGDRGS(ph)GNWR ddPTM_A459_Selumetinib_30min_R2 1 EIQSTLEGDRGSGNWR 16 1 J3QRV5;Q6P1M3 J3QRV5 LLGL2 Lethal(2) giant larvae protein homolog 2 1 EIQSTLEGDRGS(1)GNWR 83.948 0.0097384 8657500.0 9309.9 9669.7 6802.4 8346.1 6210.8 11789.0 6602.9 6750.1 5206.3 7328.3 True False 8792.49302848256 10411.334897013947 6364.740989893126 7209.346782174443 5430.543778743522 13412.82774011311 6909.947933398137 6769.741673460788 6247.705476176265 7116.712937789953 1.2354710812900949 1.462941527643957 0.894337181438943 1.013016380623223 0.763069105950189 1.8846942201210064 0.9709465583058876 0.9512455725891742 0.8778920171137952 1.0 12.796995328754118 -5.255280566353185 24.934449382175565 1.0588776763313867 1.3492063051056495 0.14310492363184046 0.2966585408971037 1000.8195410350846 4051869.0417677397 0.07756660144167288 0.19464594591011888 5.555452435880367e-06 5.255280566353185 0.2903286287742628 EIS(ph)DDEAEEEK ddPTM_A459_Selumetinib_30min_R1 2 EISDDEAEEEK 11 0 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 EIS(1)DDEAEEEK;EIS(1)DDEAEEEK 207.95 1.8016e-05 31878000.0 4886.1 4564.9 2027.2800000000002 1620.26 2643.3999999999996 2510.8 3657.0 4302.4 2676.4 4782.6 True False 4999.93662330443 4030.439385835567 1751.9865110519324 1337.312007047061 2404.304936730176 2485.5436316239998 3381.14954573241 4188.28637583522 4541.6553234781 5396.493296469004 0.9265158592110091 0.7468626688506657 0.3246527726066629 0.24781129774071647 0.44553097810819925 0.46058495676263017 0.6265456769759614 0.7761125875159838 0.8415938043413793 1.0 12.397806516536326 -7.957191286060938 1.4007404995251922 0.9580523528077078 0.5103885245006996 0.4242159489241326 0.18675238289637724 0.45903589841762865 1.618734066456091 0.1849645932509908 0.06367112446888373 1.1035924328673517e-08 7.957191286060938 -0.44766382830700824 EIS(ph)DDEAEEEK ddPTM_A459_Selumetinib_30min_R2 2 EISDDEAEEEK 11 0 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 EIS(1)DDEAEEEK;EIS(1)DDEAEEEK 193.15 2.0263e-05 125314000.0 103695.0 63442.0 72731.0 89929.0 95880.0 81258.0 169159.0 148549.0 103662.0 62416.0 True False 97932.04702397437 68307.79740181792 68051.56664352522 77680.51506382211 83834.69722192449 92450.55191331859 177025.2286821997 148981.25299638914 124397.29655828209 60613.887903756375 1.6156701114350613 1.126933113254145 1.1227058516948871 1.2815629841656813 1.3830938770177301 1.5252371215671388 2.9205390844303367 2.4578732390989964 2.0522903390688607 1.0 15.887360762593696 -7.059624922921178 8.12074011524293 2.231114551943916 1.3007052471146598 0.3815643120155031 0.47358496785048504 0.2928360463274447 36.90480526342444 0.17345913771518157 0.13482147575553066 8.717161198654976e-08 7.059624922921178 -0.9304093048292563 EIS(ph)DDEAEEEKGEK ddPTM_A459_Selumetinib_30min_R1 1 EISDDEAEEEKGEK 14 1 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 EIS(1)DDEAEEEKGEK 115.56 0.0015286 98735000.0 9448.0 9012.7 4054.4 2672.2 4799.3 5314.5 8228.9 9949.6 6011.4 12333.0 True False 9668.120017392248 7957.488894109445 3503.8347492250496 2205.5504334064635 4365.204162385237 5261.040955179918 7608.187447874602 9685.704287144408 10200.90674471538 13916.060683593076 0.6947454626143507 0.5718205083347517 0.2517835204150872 0.15848956709471596 0.31368102379229906 0.3780553329565919 0.5467199102433201 0.696009057977433 0.7330312059318745 1.0 13.764463254775963 -8.075581031233812 1.0397412897195162 0.9639080389044057 0.3811353303934601 0.6292753311972391 0.1496337422931297 0.3587832911617778 0.7347378480791179 0.1559551193193297 0.055512038651852016 8.402702137549288e-09 8.075581031233812 -0.5827727085109455 EIS(ph)DDEAEEEKGEK ddPTM_A459_Selumetinib_30min_R2 6 EISDDEAEEEKGEK 14 1 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 EIS(1)DDEAEEEKGEK;EIS(1)DDEAEEEKGEK;EIS(1)DDEAEEEKGEK;EIS(1)DDEAEEEKGEK;EIS(1)DDEAEEEKGEK;EIS(1)DDEAEEEKGEK 183.06 0.00036394 301566000.0 342926.0 233457.0 254348.0 302018.0 276667.0 276282.0 546069.0 545754.0 360674.0 229623.0 True False 323867.545761545 251362.40121743068 237983.52659316376 260882.62738989055 241909.61802563843 314337.33766171284 571462.2905151951 547342.053785561 432818.87807356386 222993.18735779714 1.452365202717574 1.12722009221795 1.067223305846175 1.1699129936705153 1.0848296348959283 1.4096275378913354 2.5626894583029216 2.4545236572960385 1.9409511259153271 1.0 17.76664010962609 -7.08569430966521 5.60298942997669 2.1062854368321418 1.1766271889035707 0.4563838200589484 0.4102235508055893 0.1735817802733997 8.77560720885106 0.15152394828835192 0.11758949019364898 8.209291750075845e-08 7.08569430966521 -0.9296582479285711 EIS(ph)PGSGPGEIR ddPTM_A459_Selumetinib_30min_R1 2 EISPGSGPGEIR 12 0 E9PK52;E9PHY5;O43491-4;E9PMG5;O43491;E9PMV8;Q6R5J7 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 EIS(0.788)PGS(0.212)GPGEIR;EIS(0.997)PGS(0.003)GPGEIR 156.52 0.00043608 73343000.0 5910.099999999999 6504.5 7296.6 6706.1 6333.3 6381.0 7177.0 6748.9 3540.5 5326.3 True False 6047.793830947279 5742.950116139988 6305.761797354846 5535.005524087675 5760.454133234929 6316.812933484442 6635.633111764154 6569.89724848324 6007.96991211112 6009.98248755548 1.0062914232229616 0.9555685275342448 1.0492146708267152 0.9209686609817398 0.9584810180666525 1.0510534675540733 1.1041019047067395 1.0931641252012203 0.9996651279020318 1.0 12.553145071746023 -6.808324558407999 7.306016603908063 1.059286387489118 0.9776738657244839 0.3778871220964771 0.04504152011456364 0.21035335920342424 26.609416237496177 0.01581932891901594 0.014054203292239137 1.5548032565426792e-07 6.808324558407999 -0.08161252176463418 EIS(ph)PGSGPGEIR ddPTM_A459_Selumetinib_30min_R2 2 EISPGSGPGEIR 12 0 E9PK52;E9PHY5;O43491-4;E9PMG5;O43491;E9PMV8;Q6R5J7 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 EIS(0.987)PGS(0.013)GPGEIR;EIS(0.882)PGS(0.118)GPGEIR 136.01 0.0014423 75145000.0 213743.0 200079.0 212602.0 194637.0 198063.0 183356.0 196839.0 183464.0 144531.0 218481.0 True False 201864.0197410226 215424.41594461622 198923.41878355527 168127.10483244687 173180.5552343142 208611.6246599526 205992.40352907876 183997.84986589963 173441.23853355227 212172.88584818903 0.9514128958280632 1.0153249086631817 0.9375534389718683 0.7924061746171601 0.8162237815732305 0.9832152860908696 0.9708705365701985 0.8672071793261613 0.8174524178252 1.0 17.69488077653439 -5.524617556394169 24.99020747022397 0.8888308650930121 0.9816364863505941 0.2096093686368975 0.07083632855559635 80.64340942052974 1159004.1373890848 0.020215587561221108 0.0353365280373021 2.9880127314388496e-06 5.524617556394169 0.09280562125758196 EIS(ph)PYENK ddPTM_A459_Selumetinib_30min_R2 2 EISPYENK 8 0 H0YCZ2;Q8NG31-4;Q8NG31-2;Q8NG31 H0YCZ2 CASC5 Protein CASC5 1 EIS(1)PYENK;EIS(1)PYENK 117.71 0.008728399999999999 14034000.0 149570.0 138661.0 153477.0 158207.0 136470.0 140994.0 141003.0 121997.0 110619.0 144222.0 True False 141257.49817614965 149295.85283461222 143602.45691312297 136658.9336777023 119325.4185427205 160414.64368390082 147559.91889214388 122351.99107230954 132745.89095310317 140057.93612624228 1.0085647560080147 1.0659578240539207 1.0253075326176861 0.9757314541214126 0.8519718471016567 1.1453449059774083 1.0535634250610377 0.8735812796929026 0.9477927108211252 1.0 17.095664207835576 -5.6906922990156374 4.7893458132864835 0.9778545904578834 1.0386006066665079 0.09144451577623491 0.07974589696121044 0.5381514002345287 23.15104835352865 0.023341462635569146 0.0408589520335318 2.0384858491035513e-06 5.6906922990156374 0.06074601620862452 EIS(ph)SSPTSK ddPTM_A459_Selumetinib_30min_R2 1 EISSSPTSK 9 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EIS(0.786)S(0.106)S(0.106)PT(0.002)S(0.001)K 125.74 0.0049725 37314000.0 95964.0 88697.0 83075.0 104300.0 93801.0 67140.0 94584.0 115140.0 77275.0 103560.0 True False 90630.70505432918 95499.77469419382 77730.04494522086 90094.16007246428 82016.87978842035 76387.92556376228 98982.3434146405 115475.03833754701 92732.15924390075 100569.95371880628 0.9011707940895821 0.9495855487933436 0.7728953039250088 0.8958357515443197 0.8155207072853952 0.7595501711907219 0.9842138705899702 1.1482061397822192 0.9220662416051219 1.0 16.617839824356608 -7.450710070452159 6.572749310458028 1.034082331520476 0.851620906619077 0.5363228521216681 0.07535367663620256 0.1761386482979506 13.250246983894623 0.0317089295868423 0.021075779979450274 3.5423374416848914e-08 7.450710070452159 -0.18246142490139894 EISELNETFLS(ph)DSEKEK ddPTM_A459_Selumetinib_30min_R1 2 EISELNETFLSDSEKEK 17 1 Q8IWJ2;B8ZZW2 Q8IWJ2 GCC2 GRIP and coiled-coil domain-containing protein 2 1 EISELNET(0.007)FLS(0.856)DS(0.138)EKEK;EISELNET(0.015)FLS(0.765)DS(0.22)EKEK 66.041 0.02313 8720500.0 1864.57 1778.8600000000001 1895.3 1918.07 1348.51 1850.32 1595.33 1859.4099999999999 1002.25 1279.63 True False 1908.0108531783505 1570.5902442304218 1637.9286701376857 1583.115081133125 1226.5375085987769 1831.7074607561403 1474.9929736924482 1810.0924065851063 1700.7450485562413 1443.8829751517237 1.32144424860876 1.0877545280741217 1.1343915665780127 1.0964289408334984 0.8494715497770114 1.268598281355637 1.0215460664583675 1.2536281940680831 1.177896739434528 1.0 10.49573810305763 -2.424452801014502 0.00870722702603106 3.5296532023710525e-07 2.3438968572722447 0.05780455015021979 0.13128744201764134 69375.13632324526 54.5005221766808 6563.411374265594 8188.339127795527 0.003763112474315948 2.424452801014502 2.3438965043069246 EISS(ph)PARPCSFEEAMK ddPTM_A459_Selumetinib_30min_R1 1 EISSPARPCSFEEAMK 16 1 O94916;O94916-4;O94916-5;O94916-2 O94916 NFAT5 Nuclear factor of activated T-cells 5 1 EIS(0.023)S(0.977)PARPCSFEEAMK 81.639 0.011701 20829000.0 2619.6 2428.8 2826.3 2969.9 2740.9 2450.8 2590.7 2734.1 1527.2 2173.1 True False 2680.631583145716 2144.4349668815144 2442.5039837546246 2451.2627169275734 2492.986078945197 2426.147177148357 2395.2814132154635 2661.5827863915665 2591.546857725211 2452.038552786517 1.0932257080947703 0.8745518966023437 0.9961115745830925 0.9996835955706888 1.0166993810566913 0.9894408774247303 0.9768530802639485 1.0854571529337995 1.056894825238435 1.0 11.259765947001005 -7.750352860596445 24.99467684415488 1.053381994858161 0.9890840580881544 0.17628564103828392 0.05378472311063746 297.50745038749346 670737.4149375019 0.024457480179344848 0.013947512355567763 1.776835159845998e-08 7.750352860596445 -0.06429793677000673 EISS(ph)PARPCSFEEAMK ddPTM_A459_Selumetinib_30min_R2 1 EISSPARPCSFEEAMK 16 1 O94916;O94916-4;O94916-5;O94916-2 O94916 NFAT5 Nuclear factor of activated T-cells 5 1 EIS(0.198)S(0.802)PARPCSFEEAMK 104.16 0.0022091 17638000.0 59934.0 56064.0 67562.0 58709.0 69133.0 45655.0 47548.0 52868.0 34695.0 55295.0 True False 56603.10821481152 60363.92852582709 63215.13447594372 50712.73292132606 60447.89448313839 51943.56183517383 49759.076214574605 53021.83712723144 41634.96945929653 53698.4896763363 1.0540912520255707 1.1241271195831808 1.177223695805381 0.9443977517243657 1.1256907754293208 0.9673188603303339 0.9266382819050178 0.9873990394667833 0.7753471226145884 1.0 15.712593891091574 -6.909988857015848 1.0020768287331479 0.9049661330118397 1.099684499259915 0.46172278630844776 0.08203801009035172 0.46088897608319607 0.9732191901377351 0.0488168213655849 0.03830026229473091 1.2303003370464867e-07 6.909988857015848 0.19471836624807537 EISS(ph)SPTSK ddPTM_A459_Selumetinib_30min_R1 3 EISSSPTSK 9 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EIS(0.018)S(0.717)S(0.264)PT(0.001)SK;EIS(0.002)S(0.76)S(0.237)PTSK;EIS(0.057)S(0.794)S(0.149)PTSK 152.54 0.0010963 201212400.0 18716.199999999997 20963.5 22905.0 21437.8 20932.1 20048.9 19708.1 19053.5 13422.0 15919.5 True False 19152.251044614382 18509.083674333244 19794.626808158962 17694.090667345674 19038.795250862408 19847.226268944705 18221.50214991766 18548.13928550957 22776.15369590607 17962.922894061452 1.0662101684434733 1.0304048947653364 1.101971373194675 0.9850340488404226 1.0598940586198609 1.1048995971310551 1.0143951659416015 1.0325791295158089 1.267953652656154 1.0 14.13273450143643 EISSS(ph)PTSK ddPTM_A459_Selumetinib_30min_R1 3 EISSSPTSK 9 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EIS(0.01)S(0.144)S(0.847)PTSK;EIS(0.01)S(0.123)S(0.86)PT(0.005)S(0.003)K;EIS(0.012)S(0.133)S(0.854)PT(0.001)SK 174.57 0.00034776 216753000.0 21642.800000000003 25652.6 26572.199999999997 26920.600000000002 24228.6 23049.3 22591.5 23799.3 16319.8 18506.899999999998 True False 22147.035130442113 22649.1816664298 22963.84119064665 22219.422572248353 22037.127407906748 22817.44496908993 20887.40496647901 23168.065252978606 27693.508648967978 20882.440887471712 1.0605577791305558 1.0846041316950659 1.0996722708035371 1.0640242054068858 1.0552946145834792 1.0926617770425062 1.0002377154583628 1.109451973446176 1.3261624346597587 1.0 14.350002733719528 -8.009185200529847 24.93767936407942 1.1813232171959687 1.0670394291247305 0.1947467601159687 0.0778061352550049 503.58038420430216 1367205.5042453764 0.04205789826303302 0.01843784752940562 9.7907238076764e-09 8.009185200529847 -0.11428378807123818 EISSS(ph)PTSK ddPTM_A459_Selumetinib_30min_R2 2 EISSSPTSK 9 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EIS(0.023)S(0.104)S(0.872)PTSK;EIS(0.001)S(0.034)S(0.965)PTSK 170.89 0.00060158 193176000.0 491180.0 390090.0 376680.0 437350.0 442400.0 330590.0 492440.0 572890.0 398860.0 555780.0 True False 463882.1819493298 420008.6486629547 352444.8188981744 377782.17552916915 386821.7568938199 376125.771702773 515339.4357513482 574557.0150529556 478643.1450795505 539733.1873101392 0.8594657376196803 0.7781782898252857 0.6529982353959903 0.6999424612222142 0.716690701977431 0.6968735303776035 0.954804054795367 1.064520449291561 0.8868143674191274 1.0 19.041886873431118 -7.308110596814669 5.685998299059841 0.9848240249392174 0.7299440929741944 0.7625516964720682 0.06628767214559947 0.1015053710255773 8.15542673169559 0.028793131605320602 0.019470324442839835 4.919142495468417e-08 7.308110596814669 -0.254879931965023 EIT(ph)ALAPSTMK ddPTM_A459_Selumetinib_30min_R1 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 EIT(0.934)ALAPS(0.053)T(0.013)MK;EIT(0.863)ALAPS(0.135)T(0.002)MK 108.59 0.023107 27064000.0 6129.7 9024.2 9395.1 9820.199999999999 8450.5 7181.5 8109.3 9321.4 3724.84 6647.3 True False 6272.510083680063 7967.642468763238 8119.2970235902385 8105.286417984488 7686.153767056948 7109.260630280291 7497.608972165117 9074.166191825585 6320.781428450218 7500.545705185128 0.8362738299619821 1.0622750373023133 1.0824941734542552 1.0806262286197794 1.0247459410511304 0.9478324524261825 0.9996084640857557 1.209800799634167 0.8427095409978852 1.0 12.872779847940475 -4.7564805846637555 24.9832135516947 1.0342308169092163 0.8362735237030918 0.2829699143666391 0.09093881878513521 190.34359071975908 958871.1793430483 0.021572153463247815 0.17357629747882083 1.7519407537818643e-05 4.7564805846637555 -0.19795729320612443 EIT(ph)ALAPSTMK ddPTM_A459_Selumetinib_30min_R2 3 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 EIT(1)ALAPSTMK;EIT(0.91)ALAPS(0.09)T(0.001)MK;EIT(0.978)ALAPS(0.022)T(0.001)MK 155.86 0.0012621 45188600.0 427528.0 394504.0 434068.0 410908.0 441957.0 341203.0 331111.0 365555.0 301060.0 382223.0 True False 403767.70529018494 424761.1882697071 406140.53745750466 354941.62154416344 386434.41051428934 388200.61611755163 346508.31758399983 366618.7045291123 361280.41231923335 371187.2288553806 1.0877736999068417 1.1443313650082492 1.0941662478795635 0.9562333883056449 1.0410767948722968 1.0458350555719138 0.9335135765648984 0.9876921295477861 0.9733104596117258 1.0 18.501787548092032 -5.661125860029308 5.58708830418969 0.9927786094569735 1.1163049588709297 0.7057770298342769 0.03491155423179631 0.11269146321017666 5.228494014866183 0.009874561912072711 0.01729138017336898 2.182097440884255e-06 5.661125860029308 0.12352634941395624 EIT(ph)SHEEGGGDVSPR ddPTM_A459_Selumetinib_30min_R1 1 EITSHEEGGGDVSPR 15 0 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 EIT(0.795)S(0.014)HEEGGGDVS(0.191)PR 125.84 0.0027939 2403800.0 492.43 849.98 713.53 519.97 520.68 706.83 679.03 831.51 421.73 482.54 True False 503.9026608980173 750.4639464550185 616.636545139737 429.1670005457525 473.5845859335201 699.7199319502909 627.8102204098103 809.4556536748661 715.6450080594893 544.4787093376311 0.9254772542181211 1.3783164219000819 1.1325264598314364 0.7882163125677447 0.8697944985023287 1.2851189953809465 1.1530482453089004 1.486661718434472 1.3143672944164986 1.0 9.088731826350426 -6.786936664521028 24.91945227469416 1.2723313008067707 1.0323362169871424 0.25920343783619393 0.1906395751187619 317.7383465966467 310535.18023107795 0.07109666540407895 0.06272406649902357 1.6332901219303072e-07 6.786936664521028 -0.2399950838196283 EITALAPS(ph)TMK ddPTM_A459_Selumetinib_30min_R1 3 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 EITALAPS(0.999)T(0.001)MK;EITALAPS(0.995)T(0.005)MK;EITALAPS(0.968)T(0.032)MK 232.78 1.8509e-07 608256000.0 14218.399999999998 25481.699999999997 24473.0 26980.5 23884.7 19780.5 23072.7 23109.800000000003 9121.7 17891.100000000002 True False 14549.661055809693 22498.290717879056 21149.701020566456 22268.862161710615 21724.333102186287 19581.52612925701 21332.307663062653 22496.853032790255 15478.858677391336 20187.596959071754 0.7207227826723315 1.114461060595374 1.0476581766242543 1.1030962331404974 1.0761227869879761 0.9699780597441345 1.0567036634578983 1.1143898443385944 0.7667509267583015 1.0 14.301181568497118 -10.30758292537492 12.107883957437181 1.0000010708030977 1.0115311890543182 0.0 0.13538462745372845 0.0 0.0 0.12471997408018255 0.030249036868052328 4.925122927279448e-11 10.30758292537492 0.011530118251220411 EITALAPS(ph)TMK ddPTM_A459_Selumetinib_30min_R2 6 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 EIT(0.004)ALAPS(0.994)T(0.002)MK;EIT(0.007)ALAPS(0.988)T(0.005)MK;EITALAPS(0.994)T(0.006)MK;EIT(0.038)ALAPS(0.939)T(0.023)MK;EITALAPS(0.832)T(0.168)MK;EITALAPS(0.787)T(0.213)MK 177.36 6.5187e-05 344663800.0 599699.0 582765.0 607762.0 591366.0 594229.0 460234.0 497292.0 537801.0 423639.0 556770.0 True False 566370.1303653052 627461.2016151844 568659.2546012313 510820.93063674815 519576.6405453384 523627.0559117164 520417.063365404 539365.9118722515 508378.63746265834 540694.6034378116 1.0474861904747061 1.1604724693490533 1.051719863645053 0.94474945262793 0.9609429005612369 0.9684340338934819 0.9624972397662559 0.9975426209969324 0.9402324976619263 1.0 19.044454431684613 -5.585452016485637 4.396294273921547 0.9676727983509047 1.1051175381101286 0.7606072199695774 0.03137652448081056 0.08283554569622252 3.2048229765067107 0.007998184360086508 0.01467643819512031 2.5974547082540617e-06 5.585452016485637 0.1374447397592239 EITALAPST(ph)MK ddPTM_A459_Selumetinib_30min_R1 3 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 EITALAPS(0.368)T(0.632)MK;EITALAPS(0.364)T(0.636)MK;EITALAPS(0.266)T(0.734)MK 215.02 4.1145e-05 135154000.0 9668.3 15327.8 14684.199999999999 15398.8 12209.7 12497.5 12416.9 13514.9 6172.700000000001 9746.1 True False 9893.552578763063 13533.214050299095 12690.166294536915 12709.6886512759 11105.33479079762 12371.786496822104 11480.283236096462 13156.440949417854 10474.621063829496 10997.106870053223 0.8996504895032615 1.2306158528978266 1.1539549851146893 1.1557302117238029 1.0098414903140678 1.1250037526244598 1.0439366800516416 1.1963547417407412 0.9524887943349414 1.0 13.424836407552458 -8.281756311830122 24.602744107184183 0.976244354268476 1.1054782561338545 0.22711243179420637 0.09252131884122433 1074.520027065672 1301172.3454368461 0.08406161442069532 0.02181624317410942 5.226893944128625e-09 8.281756311830122 0.12923390186537853 EITALAPST(ph)MK ddPTM_A459_Selumetinib_30min_R2 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 EITALAPS(0.334)T(0.666)MK;EITALAPS(0.364)T(0.636)MK 222.73 1.6789e-05 47721000.0 267880.0 223760.0 246640.0 226200.0 226000.0 174086.0 209706.0 211067.0 157279.0 190761.0 True False 252992.30200860466 240921.67249819994 230771.45092132757 195391.16978323497 197607.8595343651 198064.7663046342 219457.74452455604 211681.1700259772 188739.19474243268 185253.23427339917 1.3656565997397665 1.300499143473223 1.2457080807601557 1.0547247423214976 1.0666904699905688 1.0691568602377413 1.184636507887778 1.1426584310726544 1.0188172718425466 1.0 17.499139204711305 -5.570197573328937 2.8447264935532246 1.0861715871305018 1.3304826450359004 0.7896762564935289 0.05456677372398104 0.12316694402164964 2.00876836572471 0.016069165400856754 0.03345354025375512 2.690310624086964e-06 5.570197573328937 0.24431105790539864 EITALAPSTMK ddPTM_A459_Selumetinib_30min_R1 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 0 ; 211.78 0.00026806 167412000.0 12737.5 11645.2 11912.1 12845.099999999999 14099.0 13198.4 11069.2 11340.5 8693.6 10284.8 False True 13034.258967139482 10281.774570293392 10294.502248481573 10601.944417389928 12823.747939380617 13065.636079188374 10234.241332135949 11039.713100864466 14752.404244578238 11604.954262435574 1.1231633208008813 0.885981481510425 0.8870782267366755 0.9135705473400857 1.1050235657446916 1.1258670894965028 0.8818855379088802 0.9512931159581771 1.2712160609138063 1.0 13.5024532162786 -6.252051248878671 24.581445132787636 1.0482450932173675 0.9430314572766139 0.15316069256656895 0.11750263913390391 1070.8442331146782 2803846.5506312493 0.035539946559261786 0.04523320475502096 5.596915512502513e-07 6.252051248878671 -0.10521363594075361 EITALAPSTMK ddPTM_A459_Selumetinib_30min_R2 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 0 ; 187.99 0.00026881 150125000.0 395860.0 372600.0 449830.0 454680.0 461260.0 323570.0 360870.0 400590.0 290240.0 359020.0 False True 373859.6859531361 401177.2219021693 420888.42753787176 392751.7996332501 403312.3950832802 368138.83042398887 377651.170050339 401755.6505787552 348296.1099831745 348654.1597540144 1.072293777354915 1.150645161340428 1.2071802838515413 1.1264796034854363 1.1567692046692597 1.0558853813295141 1.0831684048077408 1.152304194110879 0.9989730517740201 1.0 18.41143716879833 -8.159319445920595 0.5626920535194274 0.994576121916471 1.1445568270429078 0.47574531113075447 0.04798153524101899 0.7252953894473143 0.5503162252472351 0.04988867862192813 0.0256708281933106 6.9291594322204715e-09 8.159319445920595 0.1499807051264368 EIVHLQAGQCGNQIGAK ddPTM_A459_Selumetinib_30min_R1 2 EIVHLQAGQCGNQIGAK 17 0 P04350;M0QY85;M0R2D3;M0QZL7;M0QYM7;M0R278;M0R0X0;M0QY37;M0QX14;M0R042;M0R2T4;P68371 P04350;P68371 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 ; 178.47 1.2005999999999998e-07 52119000.0 11919.8 12163.3 15735.599999999999 16483.8 14620.3 11455.3 12240.0 12074.2 7172.3 9799.400000000001 False True 12197.508148106703 10739.215181435238 13598.791949463714 13605.213769248356 13297.896446423616 11340.070082580203 11316.72694551947 11753.952993470992 12170.86925593408 11057.248444239198 1.1031232778767468 0.9712375764723227 1.2298531608511207 1.2304339400401771 1.2026406491166246 1.0255779400966933 1.0234668238295268 1.0630088536714373 1.1007140987480548 1.0 13.432704800408956 -6.774339761619221 24.999182702712297 1.0452986600537695 1.1468550304545162 0.3289558954472136 0.07486130952422038 326.8383017074291 633364.2965271275 0.0291480372974819 0.025865903051370202 1.681358169403557e-07 6.774339761619221 0.10155637040074672 EIVHLQAGQCGNQIGAK ddPTM_A459_Selumetinib_30min_R2 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0QY85;M0R2D3;M0QZL7;M0QYM7;M0R278;M0R0X0;M0QY37;M0QX14;M0R042;M0R2T4;P68371 P04350;P68371 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 239.87 2.0566999999999998e-22 12729000.0 96031.0 81255.0 82861.0 103980.0 99592.0 71261.0 83130.0 90374.0 76700.0 89213.0 False True 90693.98146255151 87486.99722399544 77529.81347223543 89817.74462449535 87080.3625962236 81076.5559070491 86995.70971896991 90636.97337777898 92042.1431770583 86637.18888678882 1.0468250716336587 1.0098088170695045 0.8948791444923929 1.0367112065681476 1.005115282653202 0.9358170197903587 1.0041381863468537 1.0461670622325567 1.0623860764611406 1.0 16.40269881219001 -7.633181321690106 4.7619313308568785 1.040226923805189 0.9866337252945759 0.1821357812197777 0.04494392997806796 0.33695527339064146 12.581467954679367 0.022441088283073184 0.012498670370490688 2.327119462375787e-08 7.633181321690106 -0.05359319851061317 EIVLADVIDNDSWR ddPTM_A459_Selumetinib_30min_R2 1 EIVLADVIDNDSWR 14 0 E9PBS1;P22234;P22234-2;D6RF62 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 131.69 0.012035 1670000.0 4650.2 5924.2 7058.4 6514.5 7951.9 5249.6 4135.1 5434.0 4546.5 6397.1 False True 4391.7605002255195 6378.567090694645 6604.270228604846 5627.213861860683 6952.9112311120325 5972.684748875884 4327.390343545206 5449.81204035287 5455.927039823947 6212.399101338117 0.7069347008436013 1.0267477968890852 1.063078871926036 0.9058036629759687 1.1191990594445893 0.9614135620471325 0.6965731391296334 0.877247573997461 0.8782318957339315 1.0 12.600934799999992 -7.034444320681112 24.804960721098855 0.8493851237061424 0.9770767908571079 0.12800021478448764 0.12480533224140135 950.9288492188042 684805.2682995796 0.046653456854901 0.03615828222138512 9.237526117969755e-08 7.034444320681112 0.12769166715096547 EKAEGDVAALNR ddPTM_A459_Selumetinib_30min_R1 1 EKAEGDVAALNR 12 1 P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A2R8YH90 P67936 TPM4 Tropomyosin alpha-4 chain 0 108.98 0.022066 10915000.0 3616.2 4176.1 4053.7 5305.1 4206.1 3820.7 4362.5 3899.3 2381.5 3441.8 False True 3700.450424099687 3687.1602705837804 3503.2298053802224 4378.66387406056 3825.6589976472706 3782.267226918036 4033.433112731099 3795.877897288552 4041.2315621219154 3883.588555971023 0.9528430653165457 0.9494209330993022 0.9020599774901492 1.1274788281390824 0.9850834975206924 0.9739103853065986 1.0385840452974064 0.9774150486287699 1.0405920977155305 1.0 11.923174648214573 -5.698776030535283 24.99999999573461 1.0168452225697737 0.9362391954439827 0.43879669035136626 0.04425480716812376 64.23706377037519 25626.936883069287 0.011730874726180765 0.02031846481933872 2.0008934818820588e-06 5.698776030535283 -0.08060602712579101 EKAEGDVAALNR ddPTM_A459_Selumetinib_30min_R2 1 EKAEGDVAALNR 12 1 P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A2R8YH90 P67936 TPM4 Tropomyosin alpha-4 chain 0 105.2 0.026548 6886600.0 38428.0 37993.0 35390.0 37302.0 29562.0 26025.0 27835.0 34011.0 21325.0 35483.0 False True 36292.32559947236 40906.94093325038 33113.04592971858 32221.40325046082 25848.157272366836 29609.70751857188 29129.382654006127 34109.966379175865 25590.595870283854 34458.513594094235 1.0532179660150058 1.1871359692154952 0.9609539842540901 0.9350781531094008 0.7501239773963115 0.8592856867641157 0.8453464649444005 0.9898850188657555 0.7426494413464708 1.0 15.072572850216213 -5.546096235514716 2.371004371547775 0.864929532865408 1.1198768343451513 0.5453665487611504 0.08800077328085694 0.20345120753103244 2.273536455503677 0.024023879148879785 0.05528657224301183 2.8438308718277905e-06 5.546096235514716 0.2549473014797433 EKAELS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 EKAELSR 7 1 A0A087WY61;Q14980-2;Q14980;Q14980-4;Q14980-3;F5H6Y5;F5H4J1 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 EKAELS(1)R 89.55 0.016947 10011000.0 4277.5 6495.9 4710.9 5235.1 5182.8 4986.1 4553.6 4469.9 2622.6 3908.2 True False 4377.157427433884 5735.357008138021 4071.1856551214205 4320.888059997825 4714.016655097658 4935.944361016577 4210.118285875609 4351.343731718538 4450.360652874631 4409.855539091739 0.9925852193188646 1.300577072717281 0.9232015922135918 0.9798253075854185 1.06897303399389 1.1192984253704583 0.9547066221454347 0.9867315818274509 1.0091851339400644 1.0 12.106515680478992 -5.280425334182582 24.999927352923873 1.0084035771465 1.1465811994094615 0.29859161380532406 0.08654259469700526 864.0375479879525 1137728.6353496034 0.021992192669546478 0.045905448772653755 5.24293732144719e-06 5.280425334182582 0.13817762226296137 EKDDLS(ph)PQPLMTDFER ddPTM_A459_Selumetinib_30min_R2 1 EKDDLSPQPLMTDFER 16 1 Q5THJ4-2;Q5THJ4 Q5THJ4-2 VPS13D Vacuolar protein sorting-associated protein 13D 1 EKDDLS(1)PQPLMTDFER 125.59 0.00065552 3841900.0 22858.0 28110.0 24902.0 27824.0 22309.0 19036.0 19469.0 20496.0 19130.0 21517.0 True False 21587.643867823943 30265.946612104028 23299.832431247578 24034.323200922794 19506.34397500953 21658.036208397083 20374.34707709162 20555.63996670454 22956.53453685958 20895.74830212005 1.033111786938671 1.448426070916699 1.1150513537188622 1.1502016033799713 0.9335077975183329 1.0364805268160553 0.9750474968644445 0.9837235627794674 1.0986222749692314 1.0 14.350921803796135 -5.8854725800716805 2.073939897504842 1.0053203986695725 1.2364000252429825 0.400852607303142 0.1079263774317116 0.2763460177330212 2.4196362076461373 0.031479378260174884 0.054651898440222176 1.3017495011761948e-06 5.8854725800716805 0.23107962657341008 EKDENLHEPPSSDDMKSDDESS(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 EKDENLHEPPSSDDMKSDDESSQK 24 2 Q99081;Q99081-3;B4DGI9;Q99081-4;Q99081-2;B4DZP2;F5GY10;H0YNP8 Q99081 TCF12 Transcription factor 12 1 EKDENLHEPPS(0.174)S(0.174)DDMKS(0.174)DDES(0.214)S(0.265)QK 49.106 0.018498 6981300.0 1939.5 2198.7 2015.2 1900.3 1494.6 1832.6 1894.1 2352.0 1422.1 2125.7 True False 1984.6865763899527 1941.2751818521022 1741.5469087012418 1568.448278048913 1359.4136938930621 1814.1657078676683 1751.2265120513405 2289.6173196272844 2413.199833925498 2398.5543010714177 0.8274511756950454 0.8093521922705472 0.7260819185637385 0.6539140170177918 0.5667637765323142 0.7563579890842134 0.7301175175684285 0.9545822325575569 1.0061059834449184 1.0 11.22794938586489 -7.795885720156606 3.670540378057587 0.9976611248342143 0.7181422986293544 0.7484874439457125 0.0700526167200121 0.1260815415923271 3.530092201977266 0.04631435599031872 0.021643587940977347 1.5999789902001494e-08 7.795885720156606 -0.2795188262048599 EKDFS(ph)PEALK ddPTM_A459_Selumetinib_30min_R2 1 EKDFSPEALK 10 1 E5RGU4;A0A087WZK9;B3KS98;O15372;E5RJT0 E5RGU4 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 EKDFS(1)PEALK 65.956 0.047945 6143800.0 80460.0 79727.0 78470.0 79108.0 80127.0 66096.0 74293.0 76397.0 50859.0 70416.0 True False 75988.35530689986 85841.8045372898 73421.32563167608 68333.35393108818 70060.72991553135 75200.12404025083 77747.77170878666 76619.30262179588 61032.221119191905 68382.90711725998 1.1112185560727683 1.2553108394484032 1.0736795016008378 0.9992753571285463 1.0245357044472285 1.0996918266621947 1.1369474476343662 1.1204452377318868 0.8925069683647195 1.0 16.061348135963676 -1.5228787452803376 0.24323351585709865 1.0142373099860498 2.0052731225195646 0.2552488051578695 0.08068613375088225 78.7578997196862 1.0585647698535712 0.11471684737875505 31.644668982920024 0.029999999999999995 1.5228787452803376 0.9910358125335148 EKDFS(ph)PEALKK ddPTM_A459_Selumetinib_30min_R2 1 EKDFSPEALKK 11 2 E5RGU4;A0A087WZK9;B3KS98;O15372;E5RJT0 E5RGU4 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 EKDFS(1)PEALKK 86.539 0.037665 16257000.0 84393.0 74612.0 61957.0 58907.0 63526.0 53612.0 58659.0 51152.0 47696.0 66216.0 True False 79702.77491194628 80334.50048460694 57970.75407368112 50883.76497975699 55545.2959503544 60996.566358719494 61386.75973060341 51300.84385133055 57236.532737587775 64304.172030170565 1.239465067282896 1.249289088846602 0.90150844406304 0.7912980351552164 0.8637899252367851 0.9485631248016195 0.9546310572477575 0.7977840664406807 0.8900905016043631 1.0 15.97262472164356 -5.2693771111437835 6.654642729722041 0.8851058356273702 1.246135319573259 0.8338401341906243 0.06258838366473042 0.04722505481115662 12.168256370615401 0.016570763981345125 0.0382547006588344 5.37802589316343e-06 5.2693771111437835 0.36102948394588874 EKDLDLEPLS(ph)DLEEGLEETR ddPTM_A459_Selumetinib_30min_R1 1 EKDLDLEPLSDLEEGLEETR 20 1 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 EKDLDLEPLS(0.994)DLEEGLEET(0.006)R 95.519 0.00057757 2110800.0 1430.1 1927.2 1541.7 1675.9 1645.7 1824.3 2023.5 1298.6 896.65 1337.8 True False 1463.418547509806 1701.562528069027 1332.3456079519176 1383.235525539217 1496.846725571933 1805.94919833187 1870.8657658708046 1264.1569095527184 1521.5495612750856 1509.5196612755055 0.969459746071313 1.1272211761927302 0.8826288534898046 0.9163415098352666 0.9916046567469917 1.1963734190821265 1.2393782034544492 0.8374564054929488 1.0079693562847767 1.0 10.55987383253048 -3.5320761350828183 15.414324451781223 1.019319468041844 1.01049216580358 0.0 0.1255132878452826 0.0 0.0 0.030336303158542046 0.0 0.00029371347050636843 3.5320761350828183 -0.008827302238264112 EKDLLPS(ph)PAGPVPSK ddPTM_A459_Selumetinib_30min_R2 2 EKDLLPSPAGPVPSK 15 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 EKDLLPS(0.976)PAGPVPS(0.024)K;EKDLLPS(0.995)PAGPVPS(0.005)K 74.325 0.022433 18328800.0 133049.0 98693.0 105840.0 135544.0 136397.0 116579.0 134392.0 140418.0 125933.0 116507.0 True False 125654.66921734679 106262.43575198774 99030.36962987878 117082.67337355782 119261.58945534873 132636.6990512041 140641.494292696 140826.59313254867 151123.11886201444 113143.14018846044 1.110581419324637 0.9391858452486678 0.8752662288224078 1.0348190193283955 1.054077067833692 1.1722911245902634 1.2430404004912015 1.2446763709932076 1.335680789929389 1.0 16.787789591820257 -6.670638667128065 1.7685125371699761 1.2270231076128182 0.976296239860749 0.505735458763918 0.09817158150372582 0.25887218975855847 1.6685082807570797 0.038743203592139897 0.03787026157780909 2.1348203443180654e-07 6.670638667128065 -0.2507268677520692 EKDLLPS(ph)PAGPVPSKDPK ddPTM_A459_Selumetinib_30min_R1 2 EKDLLPSPAGPVPSKDPK 18 2 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 EKDLLPS(1)PAGPVPSKDPK;EKDLLPS(1)PAGPVPSKDPK 67.252 0.011685 87384000.0 11972.7 12473.2 15970.0 16760.9 13220.099999999999 13646.3 12416.5 12719.1 8344.2 11260.1 True False 12251.64061518122 11012.831945366637 13801.361716930744 13833.923456059585 12024.34428919822 13509.03061184904 11479.913408418493 12381.748150540563 14159.49796374456 12705.443517662068 0.9642827972238822 0.866780599202027 1.0862558003382738 1.0888186183212571 0.9463931166576719 1.0632474649995407 0.9035429099708371 0.9745230958154645 1.1144434229360969 1.0 13.633159116968537 -5.2548045771209155 24.990320090461825 1.0181499464270856 0.9155317000584506 0.28101693774201086 0.06797688783097236 699.7030156078771 2635449.4162368453 0.017554175526069363 0.04427023947800888 5.561544581378619e-06 5.2548045771209155 -0.10261824636863492 EKDLLPS(ph)PAGPVPSKDPK ddPTM_A459_Selumetinib_30min_R2 1 EKDLLPSPAGPVPSKDPK 18 2 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 EKDLLPS(1)PAGPVPSKDPK 61.52 0.01771 36025000.0 185740.0 186520.0 196600.0 183830.0 173950.0 149810.0 166830.0 180740.0 117920.0 165670.0 True False 175417.31437613192 200825.48424367304 183950.97004189555 158792.03687556233 152096.84586726932 170444.96766022092 174587.92556737372 181265.92347688237 141507.294960088 160886.67663764567 1.0903159791858505 1.2482418584354185 1.1433573859953368 0.9869806511896511 0.9453663227181136 1.0594100843048848 1.0851608673637188 1.1266683311827959 0.8795463858004566 1.0 17.29568533284955 -5.666892422528283 5.300193216593577 1.0196801561718385 1.1746735576496308 0.4488010999370837 0.07530963583408404 0.18929513686552157 8.413966442461433 0.020826833375469363 0.03652518409460313 2.15331505833646e-06 5.666892422528283 0.15499340147779228 EKDS(ph)PHMQDPNQADEEAMTQIIR ddPTM_A459_Selumetinib_30min_R2 4 EKDSPHMQDPNQADEEAMTQIIR 23 1 P23511-2;P23511 P23511-2 NFYA Nuclear transcription factor Y subunit alpha 1 EKDS(1)PHMQDPNQADEEAMTQIIR;EKDS(1)PHMQDPNQADEEAMTQIIR;EKDS(1)PHMQDPNQADEEAMTQIIR;EKDS(1)PHMQDPNQADEEAMTQIIR 133.24 2.8369e-06 31438300.0 88686.6 78275.7 84987.0 81863.0 75175.9 67768.4 72207.6 70883.6 54517.5 83140.0 True False 83757.75381258885 84279.19449395475 79519.02894684911 70713.11817844823 65731.63136092691 77102.88195971503 75565.396476645 71089.85954058831 65422.523346222784 80739.53217633798 1.0373822036726565 1.043840510617352 0.9848834493266168 0.8758177843290978 0.8141195470066227 0.9549582451297789 0.9359157086965467 0.8804839169160104 0.8102910876835117 1.0 16.30098760708087 -5.5901514041394975 3.509789714795269 0.8918567516309056 1.0373684776616874 0.5313254688745848 0.05564425995734869 0.17485834836621417 4.320044850084838 0.01568910593169216 0.03012459479666404 2.5694998452204855e-06 5.5901514041394975 0.14551172603078177 EKDVADGNVS(ph)DFDNEEEEQSVPPK ddPTM_A459_Selumetinib_30min_R2 1 EKDVADGNVSDFDNEEEEQSVPPK 24 1 O43156 O43156 TTI1 TELO2-interacting protein 1 homolog 1 EKDVADGNVS(0.974)DFDNEEEEQS(0.026)VPPK 47.647 0.03102 6274400.0 34522.0 23531.0 28719.0 32294.0 32122.0 32067.0 39843.0 38305.0 31156.0 30191.0 True False 32603.405442515454 25335.752035909627 26871.25080688295 27895.501489742717 28086.547185676467 36483.93817475673 41695.77844740675 38416.46120826586 37388.07057137463 29319.30738436151 1.1120114474431833 0.8641320104793249 0.9165036013509542 0.9514379423786038 0.9579539795219522 1.2443656221639374 1.4221269930014333 1.3102786059931497 1.2752030626520487 1.0 14.839563402361238 -6.7836313194889835 4.918242520784766 1.2843319889106941 0.9504253728329762 0.6023155846238832 0.11643912728944382 0.11290245604092965 6.934894763006949 0.03930961876085342 0.036003921208366714 1.645768253064456e-07 6.7836313194889835 -0.3339066160777179 EKEAVIT(ph)PVASATQSVSR ddPTM_A459_Selumetinib_30min_R1 2 EKEAVITPVASATQSVSR 18 1 P28749;P28749-2;H0YE05 P28749 RBL1 Retinoblastoma-like protein 1 1 EKEAVIT(0.65)PVAS(0.228)AT(0.022)QS(0.094)VS(0.006)R;EKEAVIT(0.937)PVAS(0.048)AT(0.011)QS(0.004)VSR 97.049 0.0049968 82287000.0 13818.2 16390.9 19396.9 21361.7 17165.699999999997 15581.9 15129.0 14570.699999999999 8192.6 11378.1 True False 14140.13717446333 14471.845808077325 16762.90751954503 17631.280103771744 15613.065465850488 15425.160233233235 13987.80734957222 14184.23770369612 13902.243836170486 12838.58996707941 1.1013777377984137 1.1272145808212501 1.3056657750211136 1.3733034662670671 1.2161043779640415 1.201468406794382 1.0895127413087904 1.1048127356716904 1.0828481844048674 1.0 13.648199142819143 -7.24854410279703 2.1415755971191706 1.069665356115514 1.2320085364015743 0.48222114083327616 0.07738678546379435 0.33285612420800037 2.9861795879318804 0.04257672619666793 0.027776033067743205 5.642296406657341e-08 7.24854410279703 0.1623431802860602 EKEEPPS(ph)PIEATPPQSLLEK ddPTM_A459_Selumetinib_30min_R1 2 EKEEPPSPIEATPPQSLLEK 20 1 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 EKEEPPS(1)PIEATPPQSLLEK;EKEEPPS(1)PIEATPPQSLLEK 126.1 0.00011952 8496900.0 5304.9 11530.0 5263.8 6221.1 5226.3 6573.9 7240.9 6274.700000000001 3437.3999999999996 7429.3 True False 5428.493848461491 10180.062239848427 4549.004871983724 5134.701669510127 4753.582087778208 6507.772534623624 6694.713083317964 6108.274572901931 5833.0167422371915 8382.923022510176 0.6475657516936124 1.2143809757661495 0.5426513949571701 0.6125192436721906 0.567055438182325 0.7763130494158995 0.7986132122818067 0.7286568845377365 0.6958213413834446 1.0 13.033237666388745 -10.054637816045812 13.168250351850794 0.9999999989411741 0.7350271198377727 0.16617540838991618 0.18027370504057663 0.0 0.0 0.17686803104313578 0.04289679845799249 8.81783938439217e-11 10.054637816045812 -0.2649728791034014 EKEIS(ph)DDEAEEEK ddPTM_A459_Selumetinib_30min_R1 6 EKEISDDEAEEEK 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK 188.19 0.00047862 265330000.0 28357.800000000003 27107.199999999997 18906.300000000003 15964.500000000002 15841.2 18920.4 24428.1 27758.699999999997 17931.7 30808.200000000004 True False 29018.48156532662 23933.476422204607 16338.928304872126 13176.599765780078 14408.366256991012 18730.077954348697 22585.468749823864 27022.449103034836 30428.785220449954 34762.732567280655 0.8347583582264004 0.6884808717462921 0.4700127722482506 0.37904384358386556 0.41447737829886366 0.538797631000326 0.64970349227039 0.7773396136432865 0.8753277712434524 1.0 15.085253870974418 -7.982410884373976 1.355836817827009 0.97431760433632 0.5430774140476667 0.5985724655883393 0.12625915382000324 0.3339431453034863 1.102842634429169 0.12765032468641976 0.04361916046006518 1.0413317631393307e-08 7.982410884373976 -0.43124019028865324 EKEIS(ph)DDEAEEEK ddPTM_A459_Selumetinib_30min_R2 6 EKEISDDEAEEEK 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK;EKEIS(1)DDEAEEEK 190.19 0.00076823 668198000.0 574353.0 338909.0 410134.0 459948.0 404892.0 383720.0 767266.0 712776.0 460338.0 313279.0 True False 542432.7595772287 364902.2305358071 383746.424960136 397302.28894544503 354025.84717959363 436573.946936653 802945.3893087368 714850.060153581 552418.4629183935 304233.82127340505 1.7829469363623514 1.199413756854736 1.2613535975517842 1.3059109841321763 1.1636636771604763 1.4349947849628402 2.6392377611007154 2.349673212404509 1.8157693993592943 1.0 18.21482101892311 -7.084882386883172 8.980293673023773 2.062564186787975 1.3252519079584306 0.3006895532835091 0.431384346701825 0.3890506144655117 38.56589039648084 0.15815089355565662 0.12254700983601718 8.224653550948718e-08 7.084882386883172 -0.7373122788295443 EKEIS(ph)DDEAEEEKGEK ddPTM_A459_Selumetinib_30min_R1 4 EKEISDDEAEEEKGEK 16 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 EKEIS(1)DDEAEEEKGEK;EKEIS(1)DDEAEEEKGEK;EKEIS(1)DDEAEEEKGEK;EKEIS(1)DDEAEEEKGEK 140.2 0.00045229 591770000.0 13639.699999999999 17336.9 9870.800000000001 9522.199999999999 7464.0 10631.599999999999 12884.599999999999 13714.099999999999 9687.2 19379.0 True False 13957.47847176387 15307.087688293856 8530.399576423299 7859.326523831687 6788.882517876234 10524.65575672045 11912.70424854902 13350.357518325061 16438.47087490548 21866.483417445088 0.6383046695395287 0.7000251204581829 0.39011300599060855 0.3594234323732875 0.3104697901474208 0.4813145102391671 0.544792869577056 0.6105397591125302 0.7517656388128172 1.0 14.416433603404077 -8.425432796784566 1.149115145438962 0.9958845440380786 0.4758575698189772 0.6760905918240312 0.11281996474950662 0.31493653129610916 0.9008486435884256 0.12198099699732655 0.03911097204761141 3.754630495506986e-09 8.425432796784566 -0.5200269742191014 EKELS(ph)PPPGLPSK ddPTM_A459_Selumetinib_30min_R1 1 EKELSPPPGLPSK 13 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 EKELS(1)PPPGLPSK 78.848 0.022148 218840000.0 7315.4 9355.5 10726.0 11590.0 8664.9 8815.9 8619.3 7641.3 5070.1 7770.9 True False 7485.834586709486 8260.153710746046 9269.468113700643 9566.024071245009 7881.161324912344 8727.220050196753 7969.139261561758 7438.627901559512 8603.589394547267 8768.370709975947 0.8537315351177734 0.9420397453483927 1.0571482913187724 1.0909693930209357 0.8988170762380966 0.9953069206195427 0.9088506320216494 0.8483477886144161 0.9812073051107197 1.0 13.09809307864234 -7.26447059874258 24.76544689492999 0.9219637465718017 0.9774096994599408 0.04618453136933198 0.07582163294741137 595.4627723087971 4864963.852585384 0.032128594866597394 0.0227256470707417 5.4391295278101595e-08 7.26447059874258 0.05544595288813914 EKELS(ph)PPPGLPSK ddPTM_A459_Selumetinib_30min_R2 4 EKELSPPPGLPSK 13 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 EKELS(0.999)PPPGLPS(0.001)K;EKELS(0.999)PPPGLPS(0.001)K;EKELS(1)PPPGLPSK;EKELS(1)PPPGLPSK 158.29 0.001731 232263200.0 397506.0 361987.0 380661.0 382585.0 384201.0 285160.0 331822.0 362344.0 255997.0 346067.0 True False 375414.20786259655 389750.23892834166 356169.68569235987 330476.2630040631 335934.2355794806 324438.201575253 347252.380492819 363398.36105072143 307203.5531538129 336075.1465199513 1.1170543604607486 1.159711579282772 1.059791803650127 0.9833403821321973 0.9995807159740021 0.9653739794055034 1.0332581391055176 1.0813009078883138 0.9140918521791839 1.0 18.35842433062573 -5.486331960043181 3.4852752811253676 1.0007791469399736 1.1371736060779527 0.6419556880856501 0.042111229913164336 0.1451738597350812 3.603144737273973 0.01144298037954955 0.024584642510468296 3.263382948378831e-06 5.486331960043181 0.1363944591379791 EKENGFSS(ph)PPQIK ddPTM_A459_Selumetinib_30min_R2 1 EKENGFSSPPQIK 13 1 P11387 P11387 TOP1 DNA topoisomerase 1 1 EKENGFS(0.011)S(0.989)PPQIK 89.46600000000002 0.012331 7218200.0 68486.0 50706.0 57612.0 45339.0 38470.0 48511.0 67254.0 79479.0 64158.0 51862.0 True False 64679.82229117996 54594.98715451246 53905.306643202784 39163.74998586254 33637.05467383642 55192.94991098713 70381.44426127285 79710.27073154325 76991.39272429893 50364.609306341496 1.2842315900390795 1.083995049429249 1.0703012965974794 0.7776045625143242 0.6678708548941552 1.0958677267856358 1.3974385035567227 1.5826643317474676 1.528680432245601 1.0 15.620122702302561 -7.194399984858411 3.848258236178722 1.4290800508279782 0.9706326198128218 0.42272938864059717 0.2171829625831069 0.21165601256622463 6.198460952133215 0.0924312520582676 0.0685541616040186 6.391459114695069e-08 7.194399984858411 -0.4584474310151564 EKEPGEQASVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EKEPGEQASVPLSPK 15 1 P42858 P42858 HTT Huntingtin 1 EKEPGEQASVPLS(1)PK;EKEPGEQASVPLS(1)PK 110.77 0.0018802 29803000.0 17558.4 23389.0 25395.0 26293.0 16812.2 21180.4 17553.8 19634.9 12337.3 17526.4 True False 17967.47655730102 20650.605006748894 21946.498484749918 21701.42113073729 15291.539478434983 20967.344406264514 16229.70273335454 19114.1186688562 20935.497019259576 19776.08416159292 0.9085457166588928 1.044221132859779 1.1097494481426284 1.0973568353275702 0.7732339402222327 1.0602374178294172 0.8206732233105177 0.9665269682649146 1.058627018786578 1.0 14.271469167632043 EKEPGEQASVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 EKEPGEQASVPLSPK 15 1 P42858 P42858 HTT Huntingtin 1 EKEPGEQASVPLS(1)PK;EKEPGEQASVPLS(1)PK;EKEPGEQASVPLS(1)PK 156.0 0.00079348 13997200.0 143073.0 98257.0 113035.0 120053.0 100932.0 94496.0 109085.0 106884.0 74516.0 113331.0 True False 135121.57542659785 105792.9959539488 105762.45116320268 103701.57429702378 88252.01981647144 107511.96625071914 114157.66864782694 107195.0147444013 89421.28215099985 110058.83956069943 1.227721244072139 0.9612403363166669 0.9609628048537873 0.9422375768357115 0.801862169079103 0.9768589845200426 1.0372421615881833 0.9739791476293126 0.8124861438474681 1.0 16.74791549679704 -4.754707543447246 4.18891846951774 0.9385934984913543 1.2588752762786868 0.5922090935353721 0.0716559050885688 0.17672062695367505 6.082488194572166 0.018516624392431014 0.17656622441888953 1.7591078091187865e-05 4.754707543447246 0.32028177778733247 EKEVDGLLTSEPMGS(ph)PVSSK ddPTM_A459_Selumetinib_30min_R1 15 EKEVDGLLTSEPMGSPVSSK 20 1 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EKEVDGLLTSEPMGS(0.972)PVS(0.021)S(0.007)K;EKEVDGLLTSEPMGS(0.984)PVS(0.013)S(0.004)K;EKEVDGLLTSEPMGS(0.88)PVS(0.095)S(0.026)K;EKEVDGLLTSEPMGS(0.978)PVS(0.017)S(0.005)K;EKEVDGLLTSEPMGS(0.98)PVS(0.015)S(0.005)K;EKEVDGLLTS(0.001)EPMGS(0.876)PVS(0.057)S(0.067)K;EKEVDGLLTSEPMGS(0.943)PVS(0.042)S(0.015)K;EKEVDGLLTSEPMGS(0.898)PVS(0.083)S(0.019)K;EKEVDGLLTSEPMGS(0.896)PVS(0.084)S(0.02)K;EKEVDGLLTSEPMGS(0.864)PVS(0.108)S(0.028)K;EKEVDGLLTSEPMGS(0.861)PVS(0.108)S(0.031)K;EKEVDGLLTS(0.01)EPMGS(0.963)PVS(0.02)S(0.007)K;EKEVDGLLTSEPMGS(0.977)PVS(0.018)S(0.005)K;EKEVDGLLTSEPMGS(0.965)PVS(0.027)S(0.008)K;EKEVDGLLTSEPMGS(0.977)PVS(0.016)S(0.008)K 205.72 8.3514e-17 1256663900.0 95340.20000000001 111983.49999999999 113466.20000000001 117751.8 107442.9 99891.7 108802.70000000001 103559.7 60045.25000000001 89299.8 True False 97561.44116026473 98872.41976028326 98058.11326522281 97188.65860504119 97724.70866558464 98886.8801924068 100595.62474144374 100812.96034668619 101892.40371845498 100762.2991837124 0.9682335749642653 0.9812441812191735 0.9731627211725365 0.9645339516106549 0.9698538983058579 0.981387691562235 0.9983458650346517 1.0005027789499068 1.0112155493066126 1.0 16.620596421263286 -7.2187454590543325 2.0237674583410565 1.0042907410168707 0.9716331293755841 0.8991607640547225 0.004947214755186932 0.10318221984812595 0.8264724329047947 0.0025720456528649737 0.0016977138064138062 6.043027087421329e-08 7.2187454590543325 -0.032657611641286555 EKEVDGLLTSEPMGS(ph)PVSSK ddPTM_A459_Selumetinib_30min_R2 9 EKEVDGLLTSEPMGSPVSSK 20 1 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EKEVDGLLTSEPMGS(0.893)PVS(0.041)S(0.067)K;EKEVDGLLTSEPMGS(0.874)PVS(0.095)S(0.031)K;EKEVDGLLTSEPMGS(0.905)PVS(0.037)S(0.059)K;EKEVDGLLTS(0.002)EPMGS(0.945)PVS(0.043)S(0.01)K;EKEVDGLLTSEPMGS(0.863)PVS(0.109)S(0.029)K;EKEVDGLLTSEPMGS(0.825)PVS(0.105)S(0.07)K;EKEVDGLLTSEPMGS(0.82)PVS(0.137)S(0.043)K;EKEVDGLLTS(0.001)EPMGS(0.862)PVS(0.102)S(0.035)K;EKEVDGLLTSEPMGS(0.986)PVS(0.006)S(0.008)K 147.52 3.9775e-05 305739000.0 775959.0 764902.0 806308.0 899974.0 867234.0 654966.0 706227.0 715991.0 583021.3 789110.0 True False 732834.3051899914 823567.5238524225 754431.0211217713 777395.9886582571 758284.3117496709 745181.6213106228 739067.9548622513 718074.4152713091 699641.8509762018 766326.3439459933 0.9562953315900069 1.0746955658756046 0.9844774710954471 1.0144450791750985 0.989505734391288 0.9724076787880064 0.964429789868136 0.9370347515051828 0.9129815991625481 1.0 19.547599376415825 -6.858126217398025 1.2398544905660898 0.9459432958974822 1.0118287862583224 0.32300706497675624 0.034771909480640704 0.4602769321047062 1.4788281387722408 0.017285676713368253 0.014240470832429965 1.386352859717045e-07 6.858126217398025 0.06588549036084024 EKFEEMIQQIK ddPTM_A459_Selumetinib_30min_R1 1 EKFEEMIQQIK 11 1 E7ENZ3;B7ZAR1;E9PCA1;P48643-2;P48643 E7ENZ3 CCT5 T-complex protein 1 subunit epsilon 0 107.06 0.028857 9178200.0 1443.4 1567.2 1220.8 1941.7 1476.6 1162.2 1306.8 986.44 602.24 989.65 False True 1477.0284116325113 1383.711495428486 1055.0220653743936 1602.6185452231614 1343.041790714903 1150.5093231931698 1208.2270238892843 960.2764067913013 1021.9572941307171 1116.6812175073287 1.322694774905908 1.2391284761798231 0.9447835683396095 1.4351620857388008 1.2027083196696544 1.030293431245627 1.0819802508958694 0.85993781549836 0.9151737112691339 1.0 10.125001678576021 -7.1093378131451015 1.4968879125815309 0.9292105316098469 1.2248784097910725 0.5002707903430643 0.12700835467497318 0.3511780958830301 1.5667283551897795 0.06913337082546415 0.04677841528777712 7.774315956671869e-08 7.1093378131451015 0.29566787818122564 EKFPEFCSSPS(ph)PPVEVK ddPTM_A459_Selumetinib_30min_R1 2 EKFPEFCSSPSPPVEVK 17 1 Q68E01-4;Q68E01-3;Q68E01-2;Q68E01 Q68E01-4 INTS3 Integrator complex subunit 3 1 EKFPEFCSS(0.002)PS(0.998)PPVEVK;EKFPEFCSS(0.003)PS(0.997)PPVEVK 157.01 2.3834000000000006e-05 206383000.0 8706.2 10701.5 10419.4 10627.2 9424.599999999999 9386.5 10034.0 8964.8 4720.2 8160.0 True False 8909.037520683787 9448.56340500762 9004.502709667388 8771.359017250648 8572.146594048278 9292.080332260106 9277.127301580253 8727.024382225634 8009.834650232149 9207.41548513091 0.9675937330156356 1.0261906199699733 0.9779620268259636 0.9526407308777961 0.9310046459716593 1.0091952890869236 1.0075712686759841 0.9478256299304554 0.869933008146234 1.0 13.168580534349728 -7.988803084631211 16.773415685675026 0.9262710851983466 0.9810316151967964 0.19316895270618173 0.039554459077957786 5.498581092980903 8237.521604829688 0.02157706261486372 0.010290144082850353 1.0261170770417889e-08 7.988803084631211 0.054760529998449825 EKFPEFCSSPS(ph)PPVEVK ddPTM_A459_Selumetinib_30min_R2 4 EKFPEFCSSPSPPVEVK 17 1 Q68E01-4;Q68E01-3;Q68E01-2;Q68E01 Q68E01-4 INTS3 Integrator complex subunit 3 1 EKFPEFCSSPS(1)PPVEVK;EKFPEFCS(0.002)S(0.029)PS(0.97)PPVEVK;EKFPEFCSS(0.004)PS(0.996)PPVEVK;EKFPEFCS(0.001)S(0.006)PS(0.992)PPVEVK 108.69 0.0012727 78601800.0 315941.0 290889.0 344164.0 329520.0 328134.0 256777.0 276826.0 277998.0 217774.0 295336.0 True False 298382.2640320309 313199.25094444485 322020.86293743015 284638.8075462936 286910.8733648202 292145.70096047386 289698.95752031286 278806.92815495346 261334.8851139601 286808.882304919 1.0403522430480647 1.0920137773539005 1.1227715834653815 0.9924337254091095 1.0003556063504084 1.0186075780243131 1.0100766586870251 0.972100047649646 0.9111812821616996 1.0 18.129730178598066 -6.307094830611025 0.7405842186730335 0.9673407082477277 1.0879676322159948 0.5482730668273178 0.03789122339073403 0.5842801996424274 0.6964591330881243 0.023944089825431992 0.040128520601138744 4.930661284732816e-07 6.307094830611025 0.12062692396826713 EKFS(ph)FEPK ddPTM_A459_Selumetinib_30min_R2 1 EKFSFEPK 8 1 P23443-3;P23443-5;P23443-2;P23443;K7ERJ3;P23443-4 P23443-3 RPS6KB1 Ribosomal protein S6 kinase beta-1 1 EKFS(1)FEPK 117.25 0.042495 7413300.0 29213.0 35029.0 29172.0 29696.0 28575.0 26566.0 26692.0 24907.0 18215.0 29911.0 True False 27589.458408904593 37715.61166401248 27295.10528007205 25651.353571542688 24985.153036258802 30225.225357862826 27933.230889194598 24979.475246424186 21858.508969623468 29047.391711888875 0.9498084606891722 1.298416464999705 0.9396749130112213 0.8830862965587297 0.8601513445364725 1.0405486887654658 0.9616433436177245 0.8599558781107455 0.7525119358884449 1.0 14.826121003307849 -5.442879930833187 9.632519055709261 0.9084012868356713 1.123798296187829 0.37913156722120833 0.10912076912100738 0.450320864429957 51.807662259527156 0.027884032680463848 0.05809175995146521 3.606783457910325e-06 5.442879930833187 0.21539700935215766 EKGS(ph)ETDSAQDQPVK ddPTM_A459_Selumetinib_30min_R1 1 EKGSETDSAQDQPVK 15 1 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 EKGS(0.997)ET(0.002)DS(0.002)AQDQPVK 128.79 0.0044602 8458200.0 1936.9 2086.1 2292.6 2367.9 1984.6 1930.6 1952.9 2340.9 1081.0 1805.7 True False 1982.0260014486723 1841.858442198421 1981.2775123503714 1954.3907159880116 1805.0932804095885 1911.1799168445473 1805.5911807111895 2278.8117276851663 1834.3780468838074 2037.4791840074606 0.9727834360252363 0.9039888390789452 0.9724160756594589 0.9592199671674561 0.8859444035443843 0.9380119963166942 0.8861887742871674 1.1184466303125784 0.9003174419067295 1.0 10.992569604725992 EKGS(ph)ETDSAQDQPVK ddPTM_A459_Selumetinib_30min_R2 1 EKGSETDSAQDQPVK 15 1 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 EKGS(0.962)ET(0.037)DS(0.001)AQDQPVK 97.502 0.0052168 5988300.0 54597.0 47936.0 54871.0 57173.0 62870.0 45800.0 43311.0 48991.0 42082.0 65170.0 True False 51562.71730910775 51612.537061466275 51340.65959902762 49385.93877107388 54971.70853506881 52108.534268994896 45325.04731911837 49133.55569910333 50499.57586932174 63288.372768005 0.8147265453975288 0.8155137318929242 0.8112178802135759 0.7803319410993073 0.8685909611956302 0.8233508303335302 0.7161670514940485 0.7763441142532023 0.7979281763877402 1.0 15.949652854072893 -11.176696504467658 6.856517783438545 1.0008456055647856 0.800118535508373 0.7217922885044601 0.037163417288346046 0.0005181199263983518 2.6159593404565528e-05 0.03880990642899136 0.009374801462154352 6.657382277245333e-12 11.176696504467658 -0.20072707005641266 EKGS(ph)PGQNDQELK ddPTM_A459_Selumetinib_30min_R1 2 EKGSPGQNDQELK 13 1 Q3T7B4;Q9H3H1-6;Q9H3H1-3;Q9H3H1-2;Q9H3H1-5;Q9H3H1-4;Q9H3H1 Q3T7B4 TRIT1 tRNA dimethylallyltransferase, mitochondrial 1 EKGS(1)PGQNDQELK;EKGS(1)PGQNDQELK 98.227 0.0069995000000000005 18730000.0 10302.900000000001 10937.5 11437.7 11651.4 9667.6 9895.0 10217.4 9822.2 5607.9 8673.3 True False 10542.937524046429 9656.9324152942 9884.523162788904 9616.701713865757 8793.167286953412 9795.465283941165 9446.693291924064 9561.683348997924 9516.196715189366 9786.602540096308 1.077282691398917 0.9867502410289126 1.0100055787788877 0.9826394475984432 0.8984902831117612 1.0009055996510072 0.9652679010126737 0.9770176432345263 0.972369795973723 1.0 13.256592393802183 -1.5228848618864999 0.9624863430051738 0.970355694484684 81.76888353505267 0.5206102879314083 0.029114181081886008 1047.5301752610364 1.726778211819285 0.009319941140695145 186423.00950146661 0.029999577482790304 1.5228848618864999 80.79852784056798 EKGS(ph)PGQNDQELK ddPTM_A459_Selumetinib_30min_R2 1 EKGSPGQNDQELK 13 1 Q3T7B4;Q9H3H1-6;Q9H3H1-3;Q9H3H1-2;Q9H3H1-5;Q9H3H1-4;Q9H3H1 Q3T7B4 TRIT1 tRNA dimethylallyltransferase, mitochondrial 1 EKGS(1)PGQNDQELK 78.705 0.022307 17821000.0 31763.0 26800.0 30723.0 28750.0 26472.0 23808.0 24384.0 25464.0 17482.0 31045.0 True False 29997.739617363393 28855.473824417917 28746.31562867318 24834.20040348371 23146.350697317335 27087.335892494102 25517.904315979355 25538.09602420788 20978.888487892258 30148.650185403043 0.9949944502618988 0.9571066580748203 0.9534859919729067 0.8237251170703354 0.7677408625253815 0.8984593249089763 0.8464028790361653 0.8470726174192887 0.6958483500548069 1.0 14.879805790815164 -5.720845355237049 5.3615974483877995 0.8330587176420307 0.9699706162957719 0.37902583315513416 0.07524691155209642 0.18529877929184513 12.635227213426566 0.019897422218341194 0.03415127587534703 1.9017553415971553e-06 5.720845355237049 0.1369118986537412 EKGSFS(ph)DTGLGDGK ddPTM_A459_Selumetinib_30min_R1 1 EKGSFSDTGLGDGK 14 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 EKGS(0.005)FS(0.604)DT(0.39)GLGDGK 161.08 3.799e-05 0.0 763.51 670.21 928.66 872.03 769.47 799.05 775.19 590.9 331.71 748.11 True False 781.2982974681579 591.7415016278242 802.5530727642393 719.7463305304394 699.8715743609622 791.0122824793518 716.7167941909506 575.2274124862936 562.8876428601554 844.1372057084908 0.9255584189212561 0.701001564231695 0.950737708676933 0.8526414019701345 0.8290969401989037 0.9370660090920281 0.8490524873730744 0.6814382882264984 0.6668200845237233 1.0 9.721333702815384 -7.625566022343768 8.464274466743076 0.7560644412882654 0.8627677906738487 0.09085983497383998 0.10846945954242682 0.4511718074497578 33.4989129209464 0.048711821300464246 0.028013366006263463 2.368285072830132e-08 7.625566022343768 0.10670334938558323 EKGSFS(ph)DTGLGDGK ddPTM_A459_Selumetinib_30min_R2 3 EKGSFSDTGLGDGK 14 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 EKGS(0.212)FS(0.743)DT(0.045)GLGDGK;EKGS(0.016)FS(0.979)DT(0.005)GLGDGK;EKGS(0.008)FS(0.99)DT(0.002)GLGDGK 107.18 0.0029066999999999995 37897000.0 243259.0 241561.0 275458.0 263107.0 244982.0 178177.0 210274.0 230437.0 158443.0 217750.0 True False 229739.63862293243 260087.95195896388 257735.33217599438 227271.37271510862 214205.170993132 202719.26442023364 220052.15765002635 231107.5335191011 190136.02726731016 211462.99171755498 1.0864295296161752 1.2299454852429017 1.2188200407201466 1.0747571992108598 1.0129676557269163 0.9586512645721003 1.040617820937404 1.0928982496747457 0.8991456411496787 1.0 17.69004567283008 -5.96695260635718 3.4457855709846243 1.0065269808306263 1.1828851793993709 0.6363619146940227 0.059823216099760684 0.14948598063889373 3.7281792917046235 0.01765046380527702 0.02641257142032501 1.079064471839707e-06 5.96695260635718 0.17635819856874457 EKLQEEGGGS(ph)DEEET(ph)GSPSEDGMQSAR ddPTM_A459_Selumetinib_30min_R2 1 EKLQEEGGGSDEEETGSPSEDGMQSAR 27 1 Q13610-2;Q13610 Q13610-2 PWP1 Periodic tryptophan protein 1 homolog 2 EKLQEEGGGS(0.997)DEEET(0.855)GS(0.122)PS(0.026)EDGMQSAR 91.776 0.00082562 0.0 12923.0 17057.0 15498.0 12908.0 14748.0 8606.5 10909.0 12829.0 10345.0 17319.0 True False 12204.791394867834 18365.21705310061 14500.875552946547 11149.908132458006 12895.224391207168 9791.967252971719 11416.29011577341 12866.330266044717 12414.28906345072 16818.955469833945 0.7256569182764079 1.0919356488005452 0.8621745612535185 0.6629370148732601 0.7667078026537212 0.5821982982554621 0.6787752150393276 0.7649898526172711 0.7381129634189636 1.0 14.037800490298073 -5.601239946926222 5.658555333319055 0.7248481431378602 0.9248539094255076 0.2121519519087366 0.13168402033906426 0.23020643630696955 12.372662193085151 0.033836361302900984 0.05971175533270203 2.504725014571994e-06 5.601239946926222 0.20000576628764744 EKLQEEGGGS(ph)DEEETGS(ph)PSEDGMQSAR ddPTM_A459_Selumetinib_30min_R2 2 EKLQEEGGGSDEEETGSPSEDGMQSAR 27 1 Q13610-2;Q13610 Q13610-2 PWP1 Periodic tryptophan protein 1 homolog 2 EKLQEEGGGS(0.99)DEEET(0.181)GS(0.798)PS(0.031)EDGMQS(0.001)AR;EKLQEEGGGS(1)DEEET(0.124)GS(0.815)PS(0.06)EDGMQSAR 125.13 1.473e-11 19643300.0 83711.0 83254.0 87590.0 92496.0 84704.0 62577.0 62001.0 63068.0 55052.0 82861.0 True False 79058.677741684 89639.31409619717 81954.55476078129 79897.88523549993 74062.72625663226 71196.41373255225 64884.169352650744 63251.51743853052 66063.93828140055 80468.58763126671 0.982478754367563 1.1139665394272074 1.0184664248902164 0.9929077617419865 0.9203930184038001 0.8847727520557142 0.8063291684697034 0.7860398610246471 0.8209904041577945 1.0 16.29613809056695 -6.374196859161107 1.3386452717778716 0.8376616996055826 1.048055973879754 0.6080015642849819 0.06361963296634576 0.2529496836674539 0.9239002642059297 0.02486883858162491 0.03172181051563419 4.224770683512784e-07 6.374196859161107 0.21039427427417134 EKLQEEGGGS(ph)DEEETGSPSEDGMQSAR ddPTM_A459_Selumetinib_30min_R1 9 EKLQEEGGGSDEEETGSPSEDGMQSAR 27 1 Q13610-2;Q13610 Q13610-2 PWP1 Periodic tryptophan protein 1 homolog 1 EKLQEEGGGS(0.799)DEEET(0.166)GS(0.027)PS(0.009)EDGMQSAR;EKLQEEGGGS(0.992)DEEET(0.007)GSPSEDGMQSAR;EKLQEEGGGS(0.812)DEEET(0.159)GS(0.023)PS(0.006)EDGMQSAR;EKLQEEGGGS(0.993)DEEET(0.006)GS(0.001)PSEDGMQSAR;EKLQEEGGGS(0.999)DEEET(0.001)GSPSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR;EKLQEEGGGS(0.998)DEEET(0.001)GS(0.001)PSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR 148.56 4.6477e-14 472467900.0 23723.78 28498.89 29487.13 32806.189999999995 35834.29 24781.9 30854.709999999995 25026.11 14324.61 19381.010000000002 True False 24276.497915559892 25162.226710025487 25482.93970721102 27077.204764955768 32593.08479655776 24532.616586164888 28527.314383430476 24362.33626653809 24307.816941879984 21868.751420524124 1.1100998611551305 1.150601889708728 1.1652672444433627 1.2381687570669186 1.4903953211507404 1.1218114886586845 1.3044784237959373 1.1140250212764182 1.111531997161336 1.0 14.416583232727431 -8.29338715618329 1.5273027841672073 1.0104994384212125 1.226555074682837 0.29935115834431736 0.10785042596861374 0.4867535308700987 2.215604169956898 0.10497200648151422 0.03181369419498369 5.08877025252965e-09 8.29338715618329 0.2160556362616246 EKLQEEGGGS(ph)DEEETGSPSEDGMQSAR ddPTM_A459_Selumetinib_30min_R2 10 EKLQEEGGGSDEEETGSPSEDGMQSAR 27 1 Q13610-2;Q13610 Q13610-2 PWP1 Periodic tryptophan protein 1 homolog 1 EKLQEEGGGS(0.753)DEEET(0.15)GS(0.069)PS(0.025)EDGMQS(0.002)AR;EKLQEEGGGS(0.621)DEEET(0.359)GS(0.018)PS(0.002)EDGMQSAR;EKLQEEGGGS(0.999)DEEETGSPSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR;EKLQEEGGGS(0.999)DEEETGSPSEDGMQSAR;EKLQEEGGGS(0.998)DEEET(0.002)GSPSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR;EKLQEEGGGS(0.997)DEEET(0.002)GSPSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR;EKLQEEGGGS(1)DEEETGSPSEDGMQSAR 153.37 1.2539e-14 614961100.0 356920.4 373100.4 367834.7 463886.0 387330.1 279926.3 281086.8 319371.7 226217.90000000002 390164.3 True False 337084.19303356676 401716.0009731289 344168.61587013985 400703.9265520151 338670.23006297235 318483.60690705094 294157.8931629274 320301.01877216913 271467.8010562393 378899.2428904064 0.8896407141438012 1.0602185370143957 0.9083380933798485 1.057547445846746 0.8938266212395943 0.8405495996178852 0.7763485905090876 0.845346156748098 0.7164643533868428 1.0 18.531454731519254 -6.559197025841171 3.382421258727251 0.8226603779164428 0.9801121769221249 0.3806189655370954 0.0848322649874935 0.22018394056346519 5.252491642367113 0.026919615169579796 0.02791024977478408 2.759325752315829e-07 6.559197025841171 0.15745179900568218 EKLQSFDS(ph)PER ddPTM_A459_Selumetinib_30min_R1 3 EKLQSFDSPER 11 1 E9PGM9;P78332;P78332-2 E9PGM9 RBM6 RNA-binding protein 6 1 EKLQS(0.011)FDS(0.989)PER;EKLQS(0.005)FDS(0.995)PER;EKLQSFDS(1)PER 152.0 0.0027814 63774100.0 12778.599999999999 15487.199999999999 17617.7 18899.4 17255.5 15502.9 15940.500000000002 14857.4 8273.8 13141.800000000001 True False 13076.316517172792 13673.951424196048 15225.313107098988 15598.974575676275 15694.743071705969 15346.954901506966 14738.095251229832 14463.333488363274 14040.03430555712 14828.678041972224 0.8818261803351982 0.9221288226430064 1.0267478371304641 1.0519464062490091 1.0584047362335582 1.0349509820138905 0.993891377876976 0.9753622978005962 0.9468163153733012 1.0 13.856102368623189 -5.133003089049888 3.6932549825454744 1.0134813439653196 0.8892640025665856 0.6441975918290592 0.032879405745105346 0.1602475329624885 3.8106042418046044 0.009848864790405034 0.03179645706016803 7.362018610193516e-06 5.133003089049888 -0.12421734139873408 EKPCVS(ph)PTVGEK ddPTM_A459_Selumetinib_30min_R1 2 EKPCVSPTVGEK 12 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 EKPCVS(0.5)PT(0.5)VGEK;EKPCVS(0.817)PT(0.183)VGEK 134.02 0.0078734 17111700.0 4225.7 4891.2 5060.7 5870.0 5173.3 4335.5 4401.9 4252.700000000001 2453.75 3718.1000000000004 True False 4324.15058821914 4318.536030142813 4373.484736435282 4844.914693546868 4705.375928420298 4291.888806319042 4069.861139009979 4139.90458128357 4163.834535190696 4195.354352360935 1.0306997276131693 1.0293614477910684 1.0424589603436247 1.1548284808934894 1.1215681759449827 1.0230098451406808 0.9700875771601188 0.9867830542022844 0.9924869714157755 1.0 12.03457695487511 -6.975693403295657 6.529028610600163 0.9874784551206106 1.0757272506711433 0.5536492588110159 0.03759972844487838 0.14543787027429433 22.10734360747294 0.015424506371959133 0.013340721399669988 1.0575638488014042e-07 6.975693403295657 0.08824879555053267 EKPCVS(ph)PTVGEK ddPTM_A459_Selumetinib_30min_R2 1 EKPCVSPTVGEK 12 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 EKPCVS(0.997)PT(0.003)VGEK 85.469 0.017166999999999998 39019000.0 145830.0 148010.0 152410.0 148780.0 149430.0 122590.0 145120.0 140290.0 113480.0 130870.0 True False 137725.35240374334 159361.89107283964 142604.106531461 128515.90734018454 130657.26747885061 139475.65973877904 151868.36754982464 140698.2206737401 136179.17089612232 127091.44305890435 1.083671324275627 1.253915190804613 1.122059071005802 1.0112081840208549 1.0280571558094087 1.0974433556013277 1.194953522397544 1.1070628933572602 1.071505426474747 1.0 16.955507372820087 -9.850913957547617 0.012763898365318101 1.5983204717039638e-06 2.1120305961185797 0.17379125176255972 0.06880334531868751 4974.709930433201 16.125566055587623 1409.2372324705764 1259.7194703163764 1.4095680344749832e-10 9.850913957547617 2.112028997798108 EKPCVSPT(ph)VGEK ddPTM_A459_Selumetinib_30min_R1 1 EKPCVSPTVGEK 12 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 EKPCVS(0.32)PT(0.68)VGEK 117.48 0.03661 0.0 2410.6 2729.9 2976.9 3412.0 2670.7 2583.2 2416.3 2245.7 1553.2 2155.7 True False 2466.762289788925 2410.282038903921 2572.653330941211 2816.1582511723896 2429.135656550381 2557.215353357939 2234.0365456257105 2186.1367409383474 2635.6669587603433 2432.405093296164 1.0141247839792193 0.990904864303559 1.0576582568551507 1.1577669603364462 0.9986558831196359 1.0513114614032664 0.9184475693554631 0.8987552060976417 1.0835641505703058 1.0 11.248167800212313 -7.239489479513556 24.113124969554686 0.9667546650294773 1.0461933102218095 0.21938838349836554 0.06376405106699312 724.340785993045 795727.1821891295 0.024964829152065268 0.019319165899287394 5.7611677442518843e-08 7.239489479513556 0.07943864519233224 EKPCVSPT(ph)VGEK ddPTM_A459_Selumetinib_30min_R2 1 EKPCVSPTVGEK 12 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 EKPCVS(0.04)PT(0.96)VGEK 162.37 0.0050867 5812500.0 20082.0 18791.0 17597.0 22490.0 18694.0 14750.0 19418.0 19331.0 13977.0 18898.0 True False 18965.922834615492 20232.20927741184 16464.828178164953 19426.82320258604 16345.492593519579 16781.678612831314 20320.975476037038 19387.25000958066 16772.790550009733 18352.36563709926 1.0334320495596452 1.102430590011376 0.8971501823656642 1.0585459981962635 0.8906477190317746 0.9144150102865863 1.1072673614870792 1.056389698905594 0.9139307096248986 1.0 14.163678419344894 -5.236400917462963 24.98505384319478 0.9836537687816133 1.0679313226124663 0.18393628009642438 0.07390236468598663 1398.0612960801259 1395074.0905409665 0.019128494140721118 0.05056335248647505 5.802285342265976e-06 5.236400917462963 0.084277553830853 EKPDS(ph)DDDLDIASLVTAK ddPTM_A459_Selumetinib_30min_R1 6 EKPDSDDDLDIASLVTAK 18 1 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK;EKPDS(0.745)DDDLDIAS(0.248)LVT(0.007)AK;EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK 108.5 0.00083323 109444000.0 37815.21000000001 45679.78 52693.0 53380.49999999999 36060.7 41496.9 39716.06999999999 37746.399999999994 27772.02 39052.99 True False 38696.2308174102 40331.57012164641 45537.58002193059 44058.59775108668 32799.016052033665 41079.47886217061 36720.25486430857 36745.24285441298 47127.089551913086 44065.82167483605 0.8781461310979667 0.9152574169444774 1.0333990900692769 0.9998360651526556 0.7443187215266126 0.9322299528486768 0.8333046671696991 0.8338717277430568 1.0694703459671373 1.0 15.427372486176727 -8.269398112664025 24.838422509146298 1.0347351868835026 0.8989812406268947 0.32036727901479445 0.08057951047442224 783.3948766067855 2444863.3830113406 0.076834267402129 0.02126200861330608 5.377765830018545e-09 8.269398112664025 -0.13575394625660797 EKPDS(ph)DDDLDIASLVTAK ddPTM_A459_Selumetinib_30min_R2 6 EKPDSDDDLDIASLVTAK 18 1 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 EKPDS(0.909)DDDLDIAS(0.087)LVT(0.004)AK;EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK;EKPDS(1)DDDLDIASLVTAK 129.07 0.00035663 20665500.0 348688.0 333418.0 310652.0 294633.0 279124.0 231261.0 286195.0 267733.0 196907.6 275897.0 True False 329309.3168686588 358990.088492156 290664.988532324 254503.47712972586 244057.94771977956 263115.10357166 299503.63458463363 268512.058704416 236294.62205803074 267931.13674350595 1.2290819233298407 1.3398595357575853 1.0848496074966512 0.9498839150350988 0.9108980415121348 0.9820251082782648 1.117838106555538 1.0021681763753578 0.8819229632285654 1.0 18.031502723460257 -5.442518871996546 3.7249818119322753 0.9822390125548357 1.2822120829219843 0.7755096405707202 0.06512629028910963 0.1088131070960941 2.8257341030937866 0.0187258264529403 0.0412930405528277 3.609783271569473e-06 5.442518871996546 0.2999730703671486 EKPELSEPSHLNGPS(ph)SDPEAAFLSR ddPTM_A459_Selumetinib_30min_R2 1 EKPELSEPSHLNGPSSDPEAAFLSR 25 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 EKPELSEPSHLNGPS(0.613)S(0.387)DPEAAFLSR 123.3 4.229e-08 9156200.0 56919.0 38360.0 66157.0 73477.0 73762.0 53027.0 53057.0 64634.0 59087.0 61800.0 True False 53755.669844810196 41302.08865315936 61900.53064629541 63469.30584510516 64495.35811935329 60330.98791882075 55524.25563045101 64822.074239265276 70906.05102872038 60015.67342431658 0.8956938542495798 0.6881883730796391 1.0314060830185594 1.057545508093712 1.0746419133442844 1.0052538691397306 0.9251625860779598 1.080085759947522 1.1814588920365483 1.0 15.873051697248233 -5.281277327332425 21.765532602189587 1.0431913082672875 0.7919412490764876 0.6273912751507909 0.07783186182715454 83.33296407909441 91430.49179897949 0.020493827925921117 0.042823407649409145 5.2326618790126735e-06 5.281277327332425 -0.2512500591907999 EKPELSEPSHLNGPSS(ph)DPEAAFLSR ddPTM_A459_Selumetinib_30min_R1 5 EKPELSEPSHLNGPSSDPEAAFLSR 25 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 EKPELSEPSHLNGPS(0.127)S(0.872)DPEAAFLS(0.001)R;EKPELSEPS(0.001)HLNGPS(0.486)S(0.498)DPEAAFLS(0.014)R;EKPELSEPSHLNGPS(0.079)S(0.921)DPEAAFLSR;EKPELSEPSHLNGPS(0.143)S(0.856)DPEAAFLSR;EKPELSEPSHLNGPS(0.318)S(0.682)DPEAAFLSR 139.75 1.0727e-08 298970000.0 22337.39 28467.0 22772.7 24426.9 30300.699999999997 22937.7 31321.8 26240.100000000002 10445.56 21089.100000000002 True False 22857.80772600524 25134.07040605075 19680.2924214871 20161.200464701877 27560.00703502309 22706.967563765265 28959.17140867415 25544.127308142837 17725.352406482543 23796.091410229674 0.9605698403133098 1.0562268388011777 0.8270388645854151 0.8472484038296643 1.1581736916330447 0.9542309773614247 1.2169717668938238 1.073458950370383 0.7448850359879947 1.0 14.538437004924779 -6.245934483808419 24.96449551679695 1.0343911571183848 0.9254655480171826 0.12144701263743662 0.1325680442149909 1745.3106877796554 2810131.846357871 0.039869234329544055 0.051260415243573214 5.676302297198543e-07 6.245934483808419 -0.10892560910120219 EKPELSEPSHLNGPSS(ph)DPEAAFLSR ddPTM_A459_Selumetinib_30min_R2 7 EKPELSEPSHLNGPSSDPEAAFLSR 25 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 EKPELSEPSHLNGPS(0.134)S(0.861)DPEAAFLS(0.004)R;EKPELSEPSHLNGPS(0.144)S(0.855)DPEAAFLSR;EKPELSEPSHLNGPS(0.254)S(0.746)DPEAAFLSR;EKPELSEPSHLNGPS(0.216)S(0.782)DPEAAFLS(0.002)R;EKPELSEPSHLNGPS(0.251)S(0.748)DPEAAFLSR;EKPELSEPSHLNGPS(0.113)S(0.887)DPEAAFLSR;EKPELSEPSHLNGPS(0.273)S(0.727)DPEAAFLSR 133.91 2.1392e-08 495264500.0 220673.7 189746.9 262419.0 299295.0 313881.0 245507.0 252512.0 294484.0 252639.0 272637.0 True False 208409.5391808132 204299.87709755418 245535.2472402039 258530.50468732687 274448.46264825715 279323.360759348 264254.3083430356 295340.8996855491 303173.85932345403 264765.2614140031 0.7871483519695258 0.7716264437655908 0.9273695723105836 0.9764517569511236 1.0365727784020458 1.054984929924704 0.9980701657451634 1.115482061763896 1.1450666061866512 1.0 18.014354319869632 -5.51164638705226 0.9084066663098057 1.0711884286802635 0.7238167883920157 0.8524675214569428 0.04520799017875647 0.32526254138188343 0.421387599752933 0.018312558689093567 0.09031780579442508 3.078602466234853e-06 5.51164638705226 -0.34737164028824785 EKPTDTEGLEGS(ph)PEKHEPSAVPATEAGEGQQPWGR ddPTM_A459_Selumetinib_30min_R2 1 EKPTDTEGLEGSPEKHEPSAVPATEAGEGQQPWGR 35 2 O60237;O60237-6 O60237 PPP1R12B Protein phosphatase 1 regulatory subunit 12B 1 EKPT(0.004)DT(0.004)EGLEGS(0.814)PEKHEPS(0.172)AVPAT(0.006)EAGEGQQPWGR 57.716 0.00023703 4570300.0 19502.0 14661.0 17869.0 14405.0 15344.0 12634.0 14473.0 13203.0 10417.0 17256.0 True False 18418.156912691524 15785.451557454888 16719.327994296156 12443.01414998897 13416.349542899565 14374.218819966847 15146.02317770544 13241.418544125678 12500.691075298811 16757.774443527604 1.0990813234036108 0.9419778032369771 0.9977057544627416 0.7425218779451269 0.8006044948338229 0.8577641898932848 0.9038206850644971 0.7901656982404334 0.7459636789733128 1.0 14.032542940729586 -5.734129226891228 18.657962064243172 0.8281204496794127 1.0058318282714833 0.5046675999299176 0.08078690439430337 10.79426147182344 7372.760714250394 0.021379129921827843 0.03697416298061983 1.8444665056015558e-06 5.734129226891228 0.17771137859207065 EKPYFPIPEEYTFIQNVPLEDR ddPTM_A459_Selumetinib_30min_R1 2 EKPYFPIPEEYTFIQNVPLEDR 22 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;Q5RI18;A0A1W2PRZ7;A0A1W2PQ74;A0A1W2PQL0;A0A1W2PP34;A0A1W2PPL4;A0A1W2PPH7 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 ; 164.46 1.6546e-09 41996000.0 9144.2 11040.4 10984.5 12093.7 11428.4 10468.6 10525.2 10044.2 6930.2 9251.4 False True 9357.242068484147 9747.784835457287 9492.865233539505 9981.762321865042 10394.703237847903 10363.295388728295 9731.275690112863 9777.795187840295 11760.043238218468 10438.907306267167 0.8963813734476189 0.9337936001793068 0.9093734578752616 0.9562075827488505 0.9957654506240586 0.9927567210513042 0.9322120988918576 0.9366684558995976 1.1265588335244758 1.0 13.349683085103525 -5.492722020382846 0.3016795924231326 1.0248323469262177 0.842190298943916 0.38579610969456735 0.04937170966071478 5.927584906304757 0.6172498571072015 0.06067661426007693 0.3864476239840445 3.2157181703228615e-06 5.492722020382846 -0.18264204798230177 EKQEASES(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 EKQEASESPVK 11 1 Q01167-2;Q01167;E9PPI7;Q01167-3 Q01167-2 FOXK2 Forkhead box protein K2 1 EKQEAS(0.023)ES(0.977)PVK;EKQEAS(0.231)ES(0.769)PVK 156.6 0.0026078000000000004 59848000.0 5889.7 7465.5 5096.1 4948.1 5182.7 5567.9 5977.8 6691.2 3626.5 5404.5 True False 6026.91855063877 6591.43578938321 4404.0776108735645 4084.007222340589 4713.925700080002 5511.891981248707 5526.88973324561 6513.727639919259 6153.905630919638 6098.2202192879895 0.9883077904560252 1.080878609226875 0.7221906478457368 0.669704778686629 0.7730002411474713 0.9038525640342093 0.9063119294650388 1.0681358504104306 1.0091314202552937 1.0 12.574172534638816 -7.520582078916755 2.3794179896388554 1.0289266982069416 0.8471959007961163 0.29302888199731214 0.11591485477197819 0.42668553667256354 4.812802910501616 0.07326898335211843 0.03932608145516377 3.015906831935444e-08 7.520582078916755 -0.18173079741082532 EKQEASES(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 EKQEASESPVK 11 1 Q01167-2;Q01167;E9PPI7;Q01167-3 Q01167-2 FOXK2 Forkhead box protein K2 1 EKQEAS(0.015)ES(0.985)PVK;EKQEAS(0.026)ES(0.974)PVK 121.42 0.021109 19109300.0 77482.0 69198.5 68438.1 74694.0 73227.0 60090.2 82467.0 83098.0 54031.5 76024.0 True False 73175.8606250213 74505.80244175295 64034.86715576925 64520.548345662995 64027.56960231398 68367.07960547504 86301.8789052605 83339.80142238556 64839.309766248225 73828.98958592615 0.9911534891027501 1.0091673048706578 0.8673404243361889 0.8739188861655829 0.867241580325236 0.9260194401808216 1.1689429774034457 1.1288221861060446 0.8782364506124624 1.0 16.17189979366266 -7.128651170498668 9.864929894646808 1.0546155603219507 0.9185520525412344 0.3225767953030241 0.08567598288901379 0.4374174663801953 32.72260064539442 0.034018260086541824 0.026349786951767203 7.436161777504739e-08 7.128651170498668 -0.1360635077807163 EKQES(ph)Y(ph)T(ph)FY(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 EKQESYTFYVK 11 1 Q9BZA7-7;Q9BZA7-2;Q9BZA8-3;Q9BZA8-2;Q9BZA8-4;Q9BZA7-6;Q9BZA7-5;Q9BZA7-4;Q9BZA7-3;Q9BZA7-8;Q9BZA8;Q9BZA7 Q9BZA7-7 PCDH11X;PCDH11Y Protocadherin-11 X-linked;Protocadherin-11 Y-linked 4 EKQES(1)Y(1)T(1)FY(1)VK 98.407 0.0069808000000000005 55109000.0 28392.0 29187.0 112650.0 137080.0 173050.0 110680.0 50647.0 81153.0 123110.0 87069.0 True False 26814.086302181204 31425.549049003177 105402.22164404647 118409.46752381037 151309.91191337138 125925.16534699476 53002.18585512662 81389.14179439764 147735.4399808042 84555.09173756988 0.31711971155330265 0.3716576778904971 1.246550851972096 1.400382461783767 1.789483150027034 1.4892676805061422 0.6268361226503935 0.9625575482432417 1.7472092684769893 1.0 16.367604012994427 -5.261803635335137 5.17342672251856 1.290812162604631 0.329885581243568 0.5528514954089273 0.3378992234527478 0.12933857551614872 11.724325313819037 0.09518780402942398 0.23322278152812842 5.472633500884369e-06 5.261803635335137 -0.960926581361063 EKQLS(ph)PEAQAR ddPTM_A459_Selumetinib_30min_R1 1 EKQLSPEAQAR 11 1 A0A0U1RRH6;O94880;O94880-2;B4DG57 A0A0U1RRH6 PHF14 PHD finger protein 14 1 EKQLS(1)PEAQAR 159.58 0.0027915 6486000.0 1202.0 1314.3 1545.4 1277.0 1330.0 1196.7 1059.8 1235.0 664.0 848.19 True False 1230.004261315145 1160.4211449985062 1335.543168274564 1053.9959222588332 1209.701734830572 1184.662284516664 979.8584327501244 1202.2437881546332 1126.7595033587875 957.0634485702429 1.2851857033644407 1.2124808932281965 1.3954593817888794 1.1012811364109638 1.2639723485812202 1.2378095582758184 1.023817631123553 1.2561798174934642 1.1773090959037809 1.0 9.902470761197991 -14.522878713447126 0.07485370871293846 0.2640810107845843 1.457884579610899 0.4077374848271358 0.08954329807546298 284.89133854612277 1.517662478046385 35.23867734856867 3.793895866924535 3.000000219896045e-15 14.522878713447126 1.1938035688263147 EKQLS(ph)PEAQARINARLQQYR ddPTM_A459_Selumetinib_30min_R2 1 EKQLSPEAQARINARLQQYR 20 3 A0A0U1RRH6;O94880;O94880-2;B4DG57 A0A0U1RRH6 PHF14 PHD finger protein 14 1 EKQLS(1)PEAQARINARLQQYR 53.278 0.037603 11464000.0 61907.0 64104.0 59858.0 68533.0 70254.0 55795.0 60865.0 49329.0 46740.0 72163.0 True False 58466.4567733563 69020.57067315257 56006.80144846269 59198.68717398088 61428.06444127118 63480.25479341858 63695.3431017095 49472.53922314443 56089.30602471592 70079.46668800895 0.8342879810094258 0.9848900674491354 0.7991898924945132 0.8447365536831369 0.8765486860045114 0.9058324469852231 0.9089016528233396 0.7059491397586435 0.8003671927816364 1.0 16.096704175471807 EKQS(ph)DDEVYAPGLDIESSLK ddPTM_A459_Selumetinib_30min_R1 2 EKQSDDEVYAPGLDIESSLK 20 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 EKQS(1)DDEVYAPGLDIESSLK;EKQS(1)DDEVYAPGLDIESSLK 92.41 0.00077194 9472100.0 7339.1 8200.9 10459.9 10684.9 7596.9 8402.5 7722.799999999999 7978.900000000001 4567.71 7549.9 True False 7510.086750597318 7240.734815505027 9039.503032117967 8818.98279541379 6909.761736341632 8317.978478859584 7140.262978338049 7767.273652880166 7751.070257661095 8519.003207253654 0.8815687197068695 0.8499509437136702 1.0610986769462798 1.0352129915744972 0.811099792808881 0.9764027875675755 0.8381570947476985 0.9117585078811316 0.9098564784036365 1.0 13.056468917920537 -6.252208475469661 24.996640432937856 0.9034071170306408 0.9567531058441291 0.08409713586268397 0.07851843855792458 1793.912738935215 4857785.180781171 0.023941536557734042 0.030470367027253947 5.594889641318943e-07 6.252208475469661 0.05334598881348829 EKQS(ph)DDEVYAPGLDIESSLK ddPTM_A459_Selumetinib_30min_R2 1 EKQSDDEVYAPGLDIESSLK 20 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 EKQS(0.999)DDEVY(0.001)APGLDIESSLK 84.208 0.0014329 3910400.0 22270.0 23256.0 19683.0 22275.0 23082.0 16517.0 16223.0 18676.0 13169.0 20313.0 True False 21032.32255387347 25039.660420173976 18416.61720923004 19241.10657348171 20182.23280430186 18792.066823602367 16977.40164526465 18730.344068021754 15803.167972603429 19726.51091048773 1.06619577325717 1.2693405607203185 0.9335972941590357 0.9753932999500712 1.0231020019648707 0.9526300372566869 0.8606388490241578 0.9495011131473656 0.8011131844000638 1.0 14.267848184203281 -5.465879481155244 0.8073495215496953 0.9110018308071999 1.201661571305129 0.46422296648046835 0.08765524697393891 0.9616639768840791 0.9073051027744305 0.03678256047643205 0.21155342979664654 3.4207435665207897e-06 5.465879481155244 0.2906597404979292 EKS(ph)PVREPVDNLSPEER ddPTM_A459_Selumetinib_30min_R1 3 EKSPVREPVDNLSPEER 17 2 Q86U06-3;Q86U06-5;Q86U06-2;Q86U06 Q86U06-3 RBM23 Probable RNA-binding protein 23 1 EKS(0.719)PVREPVDNLS(0.281)PEER;EKS(0.888)PVREPVDNLS(0.112)PEER;EKS(0.969)PVREPVDNLS(0.031)PEER 61.89 0.021353 68481000.0 4154.599999999999 5143.1 5276.5 6787.4 4994.5 5068.599999999999 5095.4 4731.799999999999 3038.34 4185.74 True False 4251.394096555655 4540.943461037676 4559.980281739829 5602.108005277688 4542.748356850597 5017.614485920584 4711.049875669924 4606.297292947444 5155.841068426414 4723.020501560272 0.9001430536139292 0.961449026007309 0.9654796713741592 1.1861282421761676 0.9618311746370524 1.0623740642800494 0.9974654723843791 0.9752863218412309 1.0916406284332572 1.0 12.20549408257596 -5.54021871237234 24.994251353966003 1.0374131806814024 0.9389630339543374 0.3358481958076863 0.06345107858949098 261.35753045663705 376725.66312195576 0.016735126349445628 0.02899388833224397 2.8825794594213784e-06 5.54021871237234 -0.09845014672706498 EKS(ph)PVREPVDNLSPEER ddPTM_A459_Selumetinib_30min_R2 1 EKSPVREPVDNLSPEER 17 2 Q86U06-3;Q86U06-5;Q86U06-2;Q86U06 Q86U06-3 RBM23 Probable RNA-binding protein 23 1 EKS(1)PVREPVDNLSPEER 69.922 0.012982 56729000.0 59626.0 50404.0 61326.0 69221.0 62862.0 53726.0 55871.0 48979.0 39911.0 54860.0 True False 56312.22562178977 54269.82472559554 57380.35192670024 59792.98038711469 54964.71356658969 61126.268823930586 58469.112206286176 49121.520781090076 47894.31520651347 53276.04925660205 1.0569895179457487 1.0186533251406653 1.0770384202163712 1.12232384385569 1.031696500276405 1.1473498819238315 1.0974746255052048 0.9220188333503889 0.8989839876420329 1.0 15.701199481304773 -7.763274985869869 24.999992439579245 0.9328760192509037 1.0789092506727045 0.6781150678000532 0.043622931256359535 27.389409685208957 373007.0539817014 0.022826237727941692 0.011845381638292804 1.7247454746599448e-08 7.763274985869869 0.1460332314218008 EKSPVREPVDNLS(ph)PEER ddPTM_A459_Selumetinib_30min_R2 1 EKSPVREPVDNLSPEER 17 2 Q86U06-3;Q86U06-5;Q86U06-2;Q86U06 Q86U06-3 RBM23 Probable RNA-binding protein 23 1 EKS(0.392)PVREPVDNLS(0.608)PEER 63.13399999999999 0.019546 68804000.0 23982.0 24303.0 31550.0 30315.0 33679.0 24064.0 24993.0 27554.0 25356.0 31938.0 True False 22649.176447552465 26166.96195353839 29520.107349042682 26186.044703708107 29447.94292591986 27378.59756875749 26155.22402268997 27634.177578189727 30427.90850583436 31015.866955110374 0.730244828568967 0.8436637283558812 0.9517743737993034 0.8442789860301979 0.9494476800709847 0.8827287532662832 0.8432852791297026 0.8909690520076383 0.9810433011552773 1.0 14.920718831215774 -4.864293292764056 2.907502744939198 0.9085822097662186 0.7152698580289799 0.5509370818626906 0.05177912435020462 0.25436975982144133 3.4361980784946518 0.012882066798616068 0.10658259183744621 1.3668054669946962e-05 4.864293292764056 -0.1933123517372387 EKT(ph)PELPEPSVK ddPTM_A459_Selumetinib_30min_R1 3 EKTPELPEPSVK 12 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 EKT(1)PELPEPSVK;EKT(1)PELPEPSVK;EKT(0.889)PELPEPS(0.111)VK 118.55 0.0062222 2049510000.0 33990.4 38198.0 43168.0 45344.0 32577.8 34676.0 35889.0 35114.0 23341.0 33787.0 True False 34782.31018619489 33725.76040223158 37306.02270485077 37425.521612297984 29631.14374207776 34327.19092328889 33181.86383560034 34182.66265365327 39607.97224080938 38123.89056324974 0.9123494394804492 0.8846358517968829 0.9785471040254384 0.9816815928113862 0.7772329451244745 0.900411537650862 0.8703692971878018 0.8966205218993129 1.03892786532627 1.0 15.218407734104161 -8.25664269517885 24.598971300955693 1.0194639407220625 0.8999474361187692 0.43164829256376147 0.05472597360319858 291.9130268153753 1497050.085220553 0.04159088155345659 0.014566964340709818 5.538055513747576e-09 8.25664269517885 -0.11951650460329333 EKT(ph)PELPEPSVK ddPTM_A459_Selumetinib_30min_R2 2 EKTPELPEPSVK 12 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 EKT(0.776)PELPEPS(0.224)VK;EKT(1)PELPEPSVK 122.66 0.0056225 1455852800.0 323818.0 367456.0 288560.0 320180.0 261429.0 234116.0 272815.0 258490.0 177944.0 263756.0 True False 305821.4919061608 395638.69364273566 269994.3637603734 276570.9316586929 228585.95181508688 266363.35390655044 285501.4380726672 259242.16310467685 213537.77217077604 256140.67895961215 1.1939590897796528 1.5446148391959222 1.054086234396785 1.079761843304484 0.8924234633231762 1.0399103921659791 1.114627474371943 1.0121085184815712 0.8336737961268789 1.0 17.966576867055295 -5.385892550868609 5.929657053372405 1.0040908144739626 1.3666474743292671 0.6373507855977953 0.11089067798616806 0.12990099107281866 5.674491694936411 0.028326290653154982 0.059977580284536446 4.1125145655756896e-06 5.385892550868609 0.3625566598553045 EKTATCHSSS(ph)SPPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R1 2 EKTATCHSSSSPPIDAASAEPYGFR 25 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EKTATCHSS(0.001)S(0.755)S(0.244)PPIDAASAEPYGFR;EKTATCHS(0.004)S(0.045)S(0.559)S(0.392)PPIDAASAEPYGFR 157.17 4.0300999999999997e-13 35379000.0 3133.4 2973.7 4044.0 4886.8 7136.5 3204.4 4285.7 3066.8999999999996 1213.9 1773.64 True False 3206.402123464953 2625.537821564375 3494.847012101938 4033.4121165970782 6491.004835051406 3172.16664536241 3962.426198563135 2985.555849304814 2059.8996402518546 2001.3039707166154 1.6021564791663423 1.3119135623481712 1.7462849538296392 2.015392052189262 3.2433877761843166 1.585049893358548 1.9799222189842018 1.491805289446242 1.0292787454542738 1.0 10.966724594204521 -8.039409068307293 2.2056820364507588 0.9884225922370609 1.9417429420214805 0.3580586102824922 0.48858353193873816 0.39327512143145416 3.488634989795896 0.446705892749982 0.14701210236629694 9.132526302492567e-09 8.039409068307293 0.9533203497844196 EKTATCHSSSS(ph)PPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R1 2 EKTATCHSSSSPPIDAASAEPYGFR 25 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EKTAT(0.001)CHS(0.008)S(0.003)S(0.381)S(0.607)PPIDAASAEPYGFR;EKTATCHSS(0.001)S(0.232)S(0.767)PPIDAASAEPYGFR 112.35 7.669100000000001e-08 15600600.0 2258.5299999999997 2100.84 2953.5 2903.3 5173.5 2436.4 3074.9 2191.23 837.0500000000001 1512.27 True False 2311.1493546656343 1854.8726761459802 2552.4309224142135 2396.2931566907364 4705.557838455611 2411.8920280742022 2842.9578173838077 2133.1114622818445 1420.4127142868572 1706.384585257219 1.3544129351808776 1.087019123456497 1.4958122245516312 1.4043101287916997 2.7576185808935323 1.4134516034148514 1.6660709677913919 1.2500766126882827 0.8324106573388586 1.0 10.73672712282697 -7.985918799623968 3.169412603300752 0.9255169005165561 1.6034799977133372 0.29711059223641967 0.4209619264656588 0.34394455850493005 6.932568523841814 0.3199902849058172 0.12072816536118752 1.0329545200150313e-08 7.985918799623968 0.677963097196781 EKTMSS(ph)DDEDCSAK ddPTM_A459_Selumetinib_30min_R1 2 EKTMSSDDEDCSAK 14 1 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 EKTMS(0.017)S(0.982)DDEDCS(0.001)AK;EKTMS(0.115)S(0.885)DDEDCSAK 173.51 0.00048871 14344900.0 3741.6000000000004 3648.8999999999996 4778.0 4468.4 3999.5 3722.8999999999996 3828.2999999999997 3181.9 2183.4 3447.6000000000004 True False 3828.7720001137664 3221.685091672413 4129.1738436753385 3688.077822256359 3637.7459311690777 3685.4510061227447 3539.5282488179873 3097.50567573217 3705.0703307734557 3890.133042467806 0.9842264925944246 0.8281683573548565 1.0614479758398934 0.9480595604300289 0.9351212134537641 0.9473843094540499 0.9098733154310313 0.796246720078033 0.952427665153336 1.0 11.925603780857186 -7.309526477782086 4.744502295266066 0.8966620553039629 0.9495033216229609 0.035321913738000976 0.0725385432355185 0.5150488210521404 26.365471799184608 0.03003212538087679 0.020264301452887528 4.903131287902944e-08 7.309526477782086 0.05284126631899799 EKTMSS(ph)DDEDCSAK ddPTM_A459_Selumetinib_30min_R2 1 EKTMSSDDEDCSAK 14 1 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 EKT(0.008)MS(0.243)S(0.749)DDEDCSAK 81.643 0.017317 15303000.0 56270.0 53708.0 63646.0 87750.0 74393.0 54792.0 43725.0 52638.0 48778.0 73140.0 True False 53142.73866665739 57827.23090156109 59551.085652525246 75798.29862280659 65047.08625814175 62339.10064774602 45758.29913944377 52791.16786530998 58534.96297119374 71028.2581594583 0.7481914950997678 0.8141440097227087 0.8384139945939991 1.0671569398849616 0.9157916573444779 0.877666188966578 0.6442266828044195 0.7432417636765625 0.8241081013106482 1.0 16.116105485797867 -7.050112132412865 24.980603314145693 0.7785616844980541 0.8832135279514439 0.07499836974142537 0.11415246486590093 716.8302476511478 357333.4465466821 0.04475269317659459 0.03466579100643054 8.910208518174257e-08 7.050112132412865 0.10465184345338985 EKTPELPEPS(ph)VK ddPTM_A459_Selumetinib_30min_R1 4 EKTPELPEPSVK 12 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 EKT(0.002)PELPEPS(0.998)VK;EKT(0.037)PELPEPS(0.963)VK;EKT(0.244)PELPEPS(0.756)VK;EKT(0.414)PELPEPS(0.586)VK 126.32 0.013062 447525000.0 14072.9 15957.9 19020.0 19906.0 14031.5 15496.9 15696.7 14104.199999999999 9752.0 14446.099999999999 True False 14400.771188903398 14089.541649373561 16437.188469381512 16429.79078189847 12762.353302462529 15341.015256059402 14512.685281514328 13730.110799101682 16548.431742100744 16300.397651930098 0.8834613422573916 0.8643679712749367 1.0083918699636887 1.007938035177507 0.782947359627841 0.9411436201522914 0.8903270700145104 0.842317536804136 1.0152164441302005 1.0 13.9926195393107 -8.28294699392649 24.4357569715632 1.0076082810268145 0.905260010995299 0.2860948045032451 0.06623808385034276 958.3449150542307 1088804.5916386559 0.06522268040687029 0.01691282293069982 5.212583273201361e-09 8.28294699392649 -0.10234827003151559 EKTPSPKEEDEEPES(ph)PPEK ddPTM_A459_Selumetinib_30min_R1 4 EKTPSPKEEDEEPESPPEK 19 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EKTPSPKEEDEEPES(1)PPEK;EKT(0.081)PS(0.081)PKEEDEEPES(0.838)PPEK;EKTPSPKEEDEEPES(1)PPEK;EKT(0.01)PS(0.002)PKEEDEEPES(0.989)PPEK 88.565 0.0053393 299406000.0 12323.240000000002 15965.369999999999 18810.38 21353.1 12851.079999999998 15674.199999999999 13192.21 13313.010000000002 8707.21 12938.220000000001 True False 12610.347515149124 14096.137058300845 16256.033714021269 17624.181932329757 11688.702083042452 15516.531779034927 12197.11097859079 12959.905728049007 14775.49942054316 14598.966565935098 0.8637835738711689 0.9655571847936453 1.1135057841664446 1.2072211997151654 0.8006527058097802 1.0628513812231652 0.8354776979249515 0.8877276120550451 1.0120921473318516 1.0 13.833578626533551 -6.2752106889535195 24.993051766853593 0.9291230794979051 1.0378047437634494 0.17054213631126092 0.11256732439134978 1455.0898820734617 2640785.2764368053 0.03582327504934311 0.04082115691933603 5.306269591239298e-07 6.2752106889535195 0.10868166426554438 EKTPSPKEEDEEPES(ph)PPEK ddPTM_A459_Selumetinib_30min_R2 4 EKTPSPKEEDEEPESPPEK 19 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EKTPSPKEEDEEPES(1)PPEK;EKTPSPKEEDEEPES(1)PPEK;EKT(0.055)PS(0.003)PKEEDEEPES(0.941)PPEK;EKTPS(0.002)PKEEDEEPES(0.998)PPEK 87.208 0.0038502 134224300.0 158738.0 159576.0 156716.0 148343.0 124449.0 96448.9 101878.9 95579.0 61596.8 150160.0 True False 149915.97743856153 171814.9660822879 146633.06317947974 128138.42749405139 108814.6040318239 109733.86049905806 106616.47071921056 95857.11906604482 73917.88115839174 145824.49063746585 1.0280576107841002 1.1782312102117123 1.0055448336454271 0.8787167843611141 0.7462025312493482 0.7525063864057467 0.7311287030946653 0.657345817887032 0.5068962067706373 1.0 17.153873509287372 -5.915179303686875 1.4219743256721198 0.7066893656220983 1.1118931732996191 0.6165224114115515 0.12010696723616128 0.25455920876766547 1.0452849474326211 0.04030915474399691 0.07898941675078408 1.2156839873042512e-06 5.915179303686875 0.40520380767752084 EKTPSPKEEDEEPES(ph)PPEKK ddPTM_A459_Selumetinib_30min_R1 2 EKTPSPKEEDEEPESPPEKK 20 3 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EKTPSPKEEDEEPES(1)PPEKK;EKTPSPKEEDEEPES(1)PPEKK 122.34 0.0010117 14606000.0 3937.54 4870.2 6107.5 6842.9 3767.9 4857.5 4079.4 4291.299999999999 2894.76 3634.19 True False 4029.2770208808934 4299.994719905443 5278.1350460960875 5647.915972141719 3427.0941102767742 4808.637960257118 3771.687573656217 4177.480783893098 4912.196295094701 4100.673686508318 0.9825890399759611 1.0486068994109223 1.2871385166446556 1.3773141693093027 0.8357392887788909 1.172645845017633 0.919772667126745 1.0187303607301124 1.1978998258887033 1.0 12.001645229598452 -6.264480768754735 24.999903482228724 1.0272756518292008 1.1730493712644914 0.20717541669104322 0.14345964465349503 483.99400503447794 3978368.608252056 0.04527205303988244 0.05355003452505155 5.439002159473594e-07 6.264480768754735 0.1457737194352906 EKVAS(ph)DTEEADRTSSK ddPTM_A459_Selumetinib_30min_R1 2 EKVASDTEEADRTSSK 16 2 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 EKVAS(1)DTEEADRTSSK;EKVAS(0.965)DT(0.035)EEADRTSSK 94.958 0.01012 21553000.0 2486.89 2215.08 5910.3 6400.9 3858.5 3799.4 2848.6000000000004 3205.9 2313.1000000000004 2379.7200000000003 True False 2544.8296983544265 1955.7374038372448 5107.713722954028 5283.10297477413 3509.4993562735053 3761.181485579186 2633.727808578982 3120.86911776918 3925.161757860258 2685.18024243575 0.9477314253012638 0.7283449255768315 1.902186543098044 1.9675040398710002 1.3069883730002452 1.4007184419647694 0.980838368671261 1.162256845349872 1.461787069571058 1.0 11.390803216873003 -7.22120683134612 22.1717155478576 1.1647419103810095 1.393884107598291 0.07848727294836166 0.3723178556432686 427.2631451096233 235459.0250458195 0.15755961769236634 0.12204060892724332 6.008874985955669e-08 7.22120683134612 0.22914219721728157 EKVASDT(ph)EEADR ddPTM_A459_Selumetinib_30min_R1 2 EKVASDTEEADR 12 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 EKVAS(0.017)DT(0.983)EEADR;EKVAS(0.011)DT(0.989)EEADR 180.95 0.0010782 40958100.0 3806.0 5185.7 4321.8 4853.8 4531.0 4429.9 4822.8 4776.8 2701.4700000000003 4462.700000000001 True False 3894.6723948131776 4578.555833233472 3734.923297948111 4006.1749471103576 4121.171850013024 4385.339228027383 4459.012313141446 4650.1037467668475 4584.197282437742 5035.531015379131 0.7734382695525793 0.9092498525478246 0.7417138900626759 0.7955814262438275 0.8184185217857776 0.8708792011476084 0.8855098498098958 0.9234584659621515 0.9103701811064294 1.0 12.297928208447077 -7.785220167150764 0.607490353877459 0.9899505272428031 0.8031339344179322 0.6723129280384617 0.043081617812434796 0.46150763897953523 0.3573566292205012 0.04165352512217246 0.023059222066079244 1.6397582810907804e-08 7.785220167150764 -0.18681659282487084 EKVEPEVLSTDTQT(ph)SPEPGTR ddPTM_A459_Selumetinib_30min_R1 2 EKVEPEVLSTDTQTSPEPGTR 21 1 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 EKVEPEVLST(0.003)DT(0.005)QT(0.561)S(0.389)PEPGT(0.04)R;EKVEPEVLSTDT(0.002)QT(0.596)S(0.336)PEPGT(0.066)R 150.34 2.5383000000000003e-06 55795000.0 8170.6 12418.0 12863.7 13943.7 10951.2 10402.5 11103.8 9670.4 4465.1 8241.8 True False 8360.959082779968 10964.094787028418 11116.880195246222 11508.694550666012 9960.665893591391 10297.860294714288 10266.23142627933 9413.909578113818 7576.9485819989795 9299.715311930375 0.8990553799054365 1.1789710135495064 1.1954000549871298 1.2375319205633954 1.0710721306503974 1.1073307030703852 1.103929645363341 1.012279329243224 0.8147505948143057 1.0 13.182970836973858 -7.932957553608821 3.1104063922410377 0.9063618535315844 1.1225492248825475 0.4201841288836142 0.09637279231687353 0.2308111968033052 4.401541547640888 0.06565778475685426 0.02618099644468858 1.1669236624377032e-08 7.932957553608821 0.2161873713509631 EKVEPEVLSTDTQT(ph)SPEPGTR ddPTM_A459_Selumetinib_30min_R2 1 EKVEPEVLSTDTQTSPEPGTR 21 1 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 EKVEPEVLST(0.001)DT(0.019)QT(0.572)S(0.407)PEPGT(0.001)R 156.51 2.5074000000000003e-07 20207000.0 66671.0 68407.0 81334.0 82961.0 80272.0 65237.0 78425.0 74062.0 55428.0 68286.0 True False 62965.69272515923 73653.59693682662 76101.0589897635 71661.56868429271 70187.513719215 74222.8045874765 82071.91789618935 74277.5081583759 66515.14878771844 66314.40575166488 0.9495024800637443 1.1106726525250887 1.1475795964265718 1.0806335044703856 1.058405227697496 1.1192561215948629 1.2376182364286492 1.1200810339239315 1.0030271406910485 1.0 16.017034686522663 -4.760405482052237 24.503823366245243 1.106106082245817 0.9495022401763173 0.3009684480260323 0.06649253341509283 24.466709932027012 579508.6958579745 0.01675478884685823 0.09947139912496254 1.736179076162545e-05 4.760405482052237 -0.15660384206949973 EKVEPEVLSTDTQTS(ph)PEPGTR ddPTM_A459_Selumetinib_30min_R2 1 EKVEPEVLSTDTQTSPEPGTR 21 1 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 EKVEPEVLST(0.002)DT(0.012)QT(0.198)S(0.705)PEPGT(0.082)R 119.43 4.1005e-05 19211000.0 68528.0 64921.0 75836.0 79212.0 76700.0 62828.0 67899.0 72003.0 54061.0 69295.0 True False 64719.48809931935 69900.23194608331 70956.79432399366 68423.18895167841 67064.26029330003 71481.98670420099 71056.43803931614 72212.51680926174 64874.71059054702 67294.27329996786 0.961738420308497 1.0387248203795776 1.054425448770357 1.0167758056718788 0.9965819824572214 1.0622298629419205 1.055906164891301 1.0730856173655454 0.9640450429023061 1.0 16.03819611717453 -6.753995354178671 24.998819208176744 1.0371744909178013 1.0174814226355875 0.033421120774860924 0.03789304304565685 577.6533401193232 1939896.077266104 0.0126389908886948 0.012403570966255113 1.7619948950731305e-07 6.753995354178671 -0.019693068282213844 EKVIET(ph)PENDFK ddPTM_A459_Selumetinib_30min_R1 2 EKVIETPENDFK 12 1 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 EKVIET(1)PENDFK;EKVIET(1)PENDFK 158.31 0.0046929 24249000.0 7018.299999999999 7813.4 8489.099999999999 8791.5 6817.2 6919.799999999999 6848.3 6983.5 4469.4 6698.7 True False 7181.812734765453 6898.603495648884 7336.326847288468 7256.2295618939215 6200.585463674415 6850.1930946756975 6331.727217402039 6798.274894395048 7584.2453679394 7558.543395863525 0.9501582988457483 0.9126895400804607 0.9706006121898213 0.9600036914341132 0.8203413196076557 0.9062848138735993 0.8376914553228773 0.8994160036331154 1.0034003869171328 1.0 12.883892524659405 -8.263234888014798 24.556718509344115 1.0017002131896322 0.9059722862756359 0.40341006026110204 0.04597557741527978 133.5810145720715 1826850.9168848281 0.04015823829782643 0.012427799390864027 5.454627679555115e-09 8.263234888014798 -0.09572792691399634 EKVIET(ph)PENDFK ddPTM_A459_Selumetinib_30min_R2 1 EKVIETPENDFK 12 1 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 EKVIET(1)PENDFK 121.92 0.038014 6725600.0 76466.0 72121.0 74483.0 74148.0 73875.0 68733.0 64921.0 67979.0 51291.0 89291.0 True False 72216.32583765096 77652.44879443456 69690.84487095867 64048.914487565504 64594.16204912056 78200.34685394818 67939.95513852099 68176.8076354707 61550.63319028037 86712.9368241207 0.8328206664724882 0.8955116922396081 0.8036960507093903 0.73863159101018 0.7449195519710801 0.9018302195503014 0.7835042569982744 0.7862357121377781 0.7098206501196371 1.0 16.403959626741525 -11.448858308341123 2.685594418855124 1.1256875792628054 0.8013305954307216 0.5006638264468188 0.06000045767970851 28772202.273456946 16236243.399740621 22709283.404594064 0.0160040063900515 3.557473647416103e-12 11.448858308341123 -0.3243569838320838 EKVSS(ph)IDLEIDSLSSLLDDMTK ddPTM_A459_Selumetinib_30min_R1 1 EKVSSIDLEIDSLSSLLDDMTK 22 1 Q15942;H7C3R3;C9IZ41 Q15942 ZYX Zyxin 1 EKVS(0.366)S(0.634)IDLEIDSLSSLLDDMTK 155.3 1.3176000000000002e-08 10063000.0 3495.5 4072.1 4560.0 4619.5 3517.9 3687.3 4026.5 3698.1 3134.1 3065.4 True False 3576.9383489410047 3595.3366389320704 3940.7770462870535 3812.791043754644 3199.706566135692 3650.2091098005285 3722.777863246252 3600.014374878259 5318.338794392734 3458.8739495245454 1.0341337675611706 1.0394529235233574 1.1393236942990508 1.1023214778551695 0.9250717467097989 1.0553171821431317 1.0762976383565475 1.0408053104603927 1.5375925437016256 1.0 11.756086723724362 EKVSS(ph)IDLEIDSLSSLLDDMTK ddPTM_A459_Selumetinib_30min_R2 2 EKVSSIDLEIDSLSSLLDDMTK 22 1 Q15942;H7C3R3;C9IZ41 Q15942 ZYX Zyxin 1 EKVS(0.135)S(0.865)IDLEIDSLSSLLDDMTK;EKVS(0.423)S(0.577)IDLEIDSLSSLLDDMTK 78.97800000000002 0.00075088 93554000.0 187757.0 177767.0 178550.0 189199.0 168717.0 154597.0 174215.0 178521.0 150045.0 228105.0 True False 177322.21759082243 191401.15728900398 167062.28739054094 163429.76981352034 147521.26211088267 175891.33345816148 182316.34270047367 179040.46655425732 180058.19260758447 221519.0159620343 0.8004830502732702 0.8640393984135785 0.7541667999246323 0.7377685798384471 0.6659530400593963 0.7940236313089579 0.8230279549983217 0.808239716020329 0.8128340216103357 1.0 17.757071024488283 -9.22803522620462 0.6974749680947019 1.0050872379507743 0.7721092988624391 0.6401790521479086 0.04963758526253922 1.8320962516511772 1.2468855369423792 0.07843061103404139 0.02060565733400397 5.915136537682994e-10 9.22803522620462 -0.2329779390883352 EKYIDQEELNK ddPTM_A459_Selumetinib_30min_R1 1 EKYIDQEELNK 11 1 P07900;P07900-2;Q14568;P08238;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 112.84 0.020962 5670500.0 3562.6 4273.2 4857.6 4792.8 4178.9 4388.5 3660.2 3249.1 2500.3 2872.3 False True 3645.6016483871317 3772.891757443215 4197.96460088684 3955.8274519985407 3800.9192328447193 4344.355674439189 3384.108167156072 3162.923313435806 4242.826485313217 3240.9876835712616 1.1248427961842866 1.164117894235823 1.2952732348125064 1.2205623218041957 1.172765713400202 1.3404418956791961 1.0441595271436221 0.9759134011736089 1.3091152758217284 1.0 11.662217822786392 -7.286880661757578 24.80856150948239 1.0802898216797785 1.2184877764555917 0.30004312177908243 0.10276015123445319 904.6519113708113 882149.0305771189 0.0419897400108452 0.028322525302587668 5.165582929955154e-08 7.286880661757578 0.1381979547758132 EKYIDQEELNK ddPTM_A459_Selumetinib_30min_R2 2 EKYIDQEELNK 11 1 P07900;P07900-2;Q14568;P08238;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 ; 182.71 9.8393e-05 30503000.0 242155.0 223044.0 246661.0 252274.0 243473.0 182699.0 214852.0 204932.0 153354.0 219428.0 False True 228696.99452327023 240150.75760050226 230791.0998041903 217913.8460030759 212885.74506376334 207864.12887360496 224843.0437211613 205528.31819168082 184029.0850687692 213092.54349758767 1.0732285173829146 1.126978699764879 1.0830557278828623 1.0226253928286457 0.9990295369775495 0.9754641127363431 1.0551427095040828 0.9645026279110865 0.8636110961379205 1.0 17.701120585871543 -6.065038420108535 0.6022543078822413 0.9544050248976776 1.1253220154561423 0.5737098323951328 0.0460400770822748 0.8405269304696728 0.5871701010388684 0.032315154563773894 0.08262189031895184 8.609175872512867e-07 6.065038420108535 0.17091699055846465 ELAEAAKEPLPVEQDDDIEVIVDETSDHTEET(ph)SPVR ddPTM_A459_Selumetinib_30min_R1 1 ELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVR 36 1 Q676U5-4;Q676U5-3;Q676U5;C9JAY7;E7EVC7;Q676U5-5;Q676U5-2;C9JK97;C9J1B2 Q676U5-4 ATG16L1 Autophagy-related protein 16-1 1 ELAEAAKEPLPVEQDDDIEVIVDET(0.01)S(0.018)DHT(0.045)EET(0.544)S(0.383)PVR 65.441 3.1509e-05 6332400.0 845.45 924.78 1264.2 1284.6 1084.4 921.27 1008.8 926.66 285.71 595.37 True False 865.1473400406732 816.5063276814423 1092.5285837535284 1060.268724928503 986.3162114663703 912.002860246233 932.7054038104607 902.0819665841077 484.82900256722723 671.7915388949006 1.287821131930068 1.2154162123336625 1.6262910746847776 1.5782704359043414 1.4681879040764103 1.3575682446767354 1.3883851608860158 1.3428004289366844 0.7216956071890585 1.0 9.391869814952319 -8.175964237972382 5.224380664121692 0.8646776560841415 1.4188819573879645 0.7326556079669675 0.13251768259368354 0.10983005423441003 4.876849517106333 0.1015726801252302 0.036268735195199804 6.668616797522841e-09 8.175964237972382 0.554204301303823 ELAEAAKEPLPVEQDDDIEVIVDETSDHTEETS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 ELAEAAKEPLPVEQDDDIEVIVDETSDHTEETSPVR 36 1 Q676U5-4;Q676U5-3;Q676U5;C9JAY7;E7EVC7;Q676U5-5;Q676U5-2;C9JK97;C9J1B2 Q676U5-4 ATG16L1 Autophagy-related protein 16-1 1 ELAEAAKEPLPVEQDDDIEVIVDET(0.006)S(0.005)DHT(0.024)EET(0.406)S(0.56)PVR 85.897 1.7885000000000004e-09 5894100.0 1078.0 1157.2 1683.6 1933.6 2089.8 1301.4 1592.4 1306.5 417.03 884.49 True False 1103.1153025771428 1021.7144860323149 1454.9763673528246 1595.93305816733 1900.7779589841568 1288.3090975766575 1472.283985951405 1271.8473758899017 707.6694513339079 998.0229071621854 1.1053005844462838 1.0237385121124072 1.4578586893260368 1.5990946166809579 1.9045434181354592 1.29086125010886 1.4752005944810933 1.2743669175954275 0.7090713512239122 1.0 9.96292911923507 -8.112881432059405 4.437624630796518 0.8625906246939351 1.4150881545734646 0.44574758727416297 0.24263142672001975 0.22847147380809554 7.105567913239603 0.19539371863610971 0.06920304933352919 7.711139642905007e-09 8.112881432059405 0.5524975298795295 ELAEDGYS(ph)GVEVR ddPTM_A459_Selumetinib_30min_R1 1 ELAEDGYSGVEVR 13 0 P23396;P23396-2;H0YEU2;E9PL09;F2Z2S8;H0YF32;H0YCJ7;E9PPU1;E9PQ96;E9PJH4;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 ELAEDGYS(1)GVEVR 124.42 0.0018887 0.0 1264.4 1567.3 1245.2 1439.1 1602.2 1104.7 1620.4 1392.0 702.39 1102.3 True False 1293.8580599058805 1383.7997873819968 1076.108679393999 1187.788200252691 1457.2812928913843 1093.587720987348 1498.1719234084753 1355.0796381467615 1191.9045294641244 1243.79094231125 1.040253643833098 1.1125662201805218 0.8651845280319707 0.9549741518823951 1.1716448828477717 0.8792375662064318 1.2045206894854266 1.0894754030196676 0.9582836543650103 1.0 10.280528300808603 ELAEDGYSGVEVR ddPTM_A459_Selumetinib_30min_R2 1 ELAEDGYSGVEVR 13 0 P23396;P23396-2;H0YEU2;E9PL09;F2Z2S8;H0YF32;H0YCJ7;E9PPU1;E9PQ96;E9PJH4;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 174.77 0.0015914999999999998 5656600.0 8152.6 7618.0 7006.9 8963.3 10140.0 5619.5 5262.0 7717.2 6447.7 8292.1 False True 7699.511129443595 8202.276104269236 6556.083682535888 7742.483077445055 8866.122547249845 6393.535116258011 5506.693426455195 7739.655774348767 7737.420163790354 8052.685527536817 0.9561420352396087 1.0185764831149662 0.8141487284107672 0.9614783851882704 1.1010143779899777 0.7939630939758909 0.6838331644300036 0.9611272845415832 0.9608496615609305 1.0 12.97525427921137 -6.789543011544657 24.99957881966003 0.8652675434899265 0.9637937337547248 0.13856607229996254 0.10898114474637281 431.2770420323735 383639.3808439174 0.04025780727199929 0.035511110882192075 1.6235175530082402e-07 6.789543011544657 0.09852619026479825 ELAGGDFT(ph)SPDASASSCGK ddPTM_A459_Selumetinib_30min_R2 1 ELAGGDFTSPDASASSCGK 19 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 ELAGGDFT(0.5)S(0.5)PDASASSCGK 202.41 3.0866e-15 4613100.0 24665.0 24778.0 32082.0 32581.0 32795.0 23846.0 27563.0 29277.0 21485.0 30684.0 True False 23294.218041818094 26678.392926172644 30017.87904824049 28143.411594640096 28674.998908980146 27130.57004756444 28844.734115048366 29362.191222931728 25782.600341057398 29798.07319339368 0.7817357146093087 0.8953059734106339 1.0073765123476353 0.9444708525945755 0.962310506551057 0.9104806834818893 0.9680066871385271 0.9853721424323977 0.8652438757944079 1.0 14.862931425531938 -4.857873246447151 3.231196804680472 0.9536628174609669 0.7709662770860067 0.6312468839014771 0.0404495328944844 0.17468475820470442 3.005758359786388 0.009807013836690014 0.07274488574124739 1.3871606276643286e-05 4.857873246447151 -0.1826965403749602 ELAGGDFTS(ph)PDASASSCGK ddPTM_A459_Selumetinib_30min_R1 1 ELAGGDFTSPDASASSCGK 19 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 ELAGGDFT(0.208)S(0.792)PDASASSCGK 213.02 7.8467e-17 4316000.0 1762.0 2372.7 2350.1 2461.8 2394.4 1773.3 1919.1 1889.0 1112.1 1919.1 True False 1803.0511717448298 2094.9031809616945 2030.9693281752625 2031.892843709317 2177.8269427656537 1755.4622120275762 1774.3407419237249 1838.89758366324 1887.1524754296788 2165.4351786169987 0.8326507251518778 0.967428257215092 0.9379035439298554 0.9383300242711623 1.0057225283264168 0.8106740988426814 0.8193922216858717 0.8492046318549656 0.871488786210146 1.0 11.08044127125021 -6.770465170026597 24.99885396126413 0.8575547608655397 0.9383203962925729 0.19954822814877315 0.06384770383096686 256.58719977709416 710668.4621340252 0.021495478216833886 0.0192265837118005 1.6964256484071158e-07 6.770465170026597 0.08076563542703319 ELAGGDFTS(ph)PDASASSCGK ddPTM_A459_Selumetinib_30min_R2 1 ELAGGDFTSPDASASSCGK 19 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 ELAGGDFT(0.026)S(0.974)PDASASSCGK 230.29 1.1619e-23 6068800.0 27049.0 26499.0 29743.0 32992.0 31926.0 28593.0 27631.0 28980.0 23243.0 34230.0 True False 25545.724865726235 28531.388092285466 27829.367761729867 28498.432685625557 27915.170457938693 32531.42620858888 28915.896249787816 29064.32700210273 27892.24946368148 33241.690959779226 0.7684845183307696 0.8583013459455782 0.837182675075164 0.8573099581518651 0.8397638523177009 0.97863331465148 0.8698683916162567 0.8743335902276784 0.8390743267973251 1.0 15.020706151466333 -13.484488766919023 0.01923304334596293 2.0374619822212243 6.840127719399353e-07 0.5019482147630878 0.04585504449428785 2699.1326162264286 4.654939305654042 314.1066024796401 192.3844514492924 3.277262533759933e-14 13.484488766919023 -2.0374612982084526 ELAPAWEDTS(ph)PEQDNR ddPTM_A459_Selumetinib_30min_R1 2 ELAPAWEDTSPEQDNR 16 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 ELAPAWEDT(0.315)S(0.685)PEQDNR;ELAPAWEDT(0.271)S(0.729)PEQDNR 228.84 3.562e-15 23334000.0 6599.8 8412.1 6495.3 7241.2 7973.200000000001 6514.4 8532.5 6725.5 3538.4 6531.5 True False 6753.562499024704 7427.207421320806 5613.273936129013 5976.660354158703 7252.025467782793 6448.871050601951 7888.8866554448405 6547.117892497153 6004.4063654890515 7369.88164719761 0.9163732638220506 1.0077783846291473 0.7616504856985669 0.8109574400602921 0.9840084027048615 0.8750304766500732 1.070422434591549 0.8883613341316937 0.8147222239005997 1.0 12.847425735953655 -6.271631829720787 24.901528814234755 0.9365724399548089 0.8756933972338206 0.10904075088528775 0.09024747971262276 1785.6153598714172 4362490.834758013 0.02907072667104221 0.03333942077408883 5.350177249443802e-07 6.271631829720787 -0.06087904272098832 ELAPAWEDTS(ph)PEQDNR ddPTM_A459_Selumetinib_30min_R2 1 ELAPAWEDTSPEQDNR 16 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 ELAPAWEDT(0.039)S(0.961)PEQDNR 219.53 9.5096e-11 9188300.0 95992.0 95444.0 92927.0 113500.0 116570.0 86504.0 80878.0 90715.0 76059.0 93412.0 True False 90657.14892642215 102764.24789916974 86948.1779912675 98041.1042015793 101925.43445097783 98419.14079487197 84638.98725671673 90978.96563132336 91272.92526602201 90714.95284647662 0.9993627961186036 1.132825897766656 0.9584768030295523 1.0807601296723512 1.1235792033478043 1.0849274315496111 0.9330213443417352 1.0029103557524144 1.0061508318313266 1.0 16.469052754111807 -7.245949704781533 24.829398463005333 0.9857631598163735 1.065247221502016 0.3409934733922658 0.05294545507102534 860.4658441693023 1379298.6175299445 0.020185028691041842 0.015578019428733455 5.6761033599929496e-08 7.245949704781533 0.07948406168564237 ELAPYDENWFYTR ddPTM_A459_Selumetinib_30min_R1 1 ELAPYDENWFYTR 13 0 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 132.14 0.020125 4687000.0 1664.5 1693.0 1912.7 2190.3 1882.6 1893.9 1990.2 2014.4 1175.0 1905.8 False True 1703.279611446803 1494.7827729456533 1652.9658457090445 1807.8052220231195 1712.3191624000256 1874.8490855236137 1840.0776116807872 1960.9715683066354 1993.8891813954447 2150.4279940640295 0.7920654010031863 0.6951094280170284 0.7686683070866994 0.8406722880344404 0.7962690065078463 0.8718492740509728 0.855679714345273 0.9118982703534536 0.9272057408568484 1.0 11.07040810887841 -7.099218034026206 0.3107189191234927 1.0117365399692109 0.6976118763586664 0.8554228999799312 0.031715498207739654 0.6626756581126638 0.1582352205058957 0.04440064312229385 0.07492359039673797 7.957597453831484e-08 7.099218034026206 -0.3141246636105445 ELAPYDENWFYTR ddPTM_A459_Selumetinib_30min_R2 1 ELAPYDENWFYTR 13 0 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 190.78 0.002305 14059000.0 14158.0 13403.0 14596.0 13569.0 16409.0 17920.0 14458.0 17418.0 15240.0 11883.0 False True 13371.155038964538 14430.967002562431 13656.909250923218 11720.878792169397 14347.55472167876 20388.317338436438 15130.325647983496 17468.683496294863 18288.425841178254 11539.906914258141 1.1586882925757223 1.2505271584757967 1.1834505557449007 1.0156822649659032 1.2432989995743924 1.766766187103783 1.311130649527962 1.5137629467973799 1.584798385035669 1.0 13.494343966194908 -6.539441890108443 24.815882625039123 1.4646852538817712 1.1573751924470181 0.32037708835298584 0.19417412273665524 229.8412496931657 344359.2572681373 0.06005037232060765 0.06006583433985455 2.887740141547779e-07 6.539441890108443 -0.30731006143475303 ELAS(ph)PVSPELR ddPTM_A459_Selumetinib_30min_R1 2 ELASPVSPELR 11 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 ELAS(0.988)PVS(0.012)PELR;ELAS(0.977)PVS(0.023)PELR 99.539 0.017157 7761100.0 2981.6000000000004 4096.6 3078.3999999999996 2527.1000000000004 3169.0 2865.1000000000004 3516.6000000000004 2911.0 1708.9299999999998 3046.8 True False 3051.0654788163356 3616.9681675423285 2660.3701884408033 2085.789424542128 2882.364509532391 2836.2796953026623 3251.340030769096 2833.7908237393817 2899.9293946911607 3437.8864583452028 0.887482910149668 1.0520906409699537 0.7738388747490369 0.6067068967560101 0.8384117813244456 0.8250067969574194 0.9457380487004509 0.8242828429835355 0.8435209916987826 1.0 11.747306182972169 -8.681731110728581 14.763423261908109 1.0000000000624008 0.8428211511697539 0.156745936554609 0.10842934941593904 21356.819044798973 1984884.351265536 0.11343251155453977 0.029287843247450568 2.0809847100931398e-09 8.681731110728581 -0.15717884889264688 ELAS(ph)PVSPELR ddPTM_A459_Selumetinib_30min_R2 3 ELASPVSPELR 11 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 ELAS(0.991)PVS(0.009)PELR;ELAS(0.989)PVS(0.011)PELR;ELAS(0.53)PVS(0.47)PELR 140.14 0.0011106 10952700.0 55111.0 40127.5 55512.7 59346.0 67546.0 51612.9 53601.0 61122.0 56394.0 47922.0 True False 52048.151246812755 43205.15021975112 51941.0733196578 51262.97242243979 59060.267611098345 58722.1084797425 56093.552708366566 61299.85490070818 67674.37578001358 46538.367343690916 1.11839229043923 0.9283770077423726 1.1160914377607472 1.101520645188456 1.269066170175929 1.2617999262001034 1.205318448198012 1.3171896308265838 1.4541630839825328 1.0 15.506132978636575 -6.053503566594954 1.6586391622650054 1.2693024774445778 1.0310287931134876 0.37109532046911775 0.11733852135208622 0.35530452067346363 1.9599308594191018 0.038677214100391336 0.0619297141105217 8.840899086809948e-07 6.053503566594954 -0.2382736843310902 ELASPVS(ph)PELR ddPTM_A459_Selumetinib_30min_R1 1 ELASPVSPELR 11 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 ELAS(0.175)PVS(0.825)PELR 138.89 0.0012132 5213100.0 1911.5 2616.3 1584.9 1827.8 1765.0 1725.1 2260.1 2022.8 1196.7 1866.8 True False 1956.0342308684685 2309.9823797151275 1369.6792852325325 1508.6090420553612 1605.3560616360592 1707.7470602654778 2089.61883738305 1969.1487730195893 2030.7124964901514 2106.4219641718582 0.9286051247749333 1.096638004638021 0.6502397470826902 0.7161950775843112 0.7621246307442519 0.8107335991138319 0.9920229056311544 0.9348311053116852 0.9640577866308605 1.0 11.04057875456765 -7.25853614755323 24.781679221064937 0.9672972119875524 0.8235820871612595 0.2737928203483109 0.11569632209280732 356.2815588315646 3041199.4433988426 0.0504092632029421 0.037300844486509055 5.5139630620376794e-08 7.25853614755323 -0.1437151248262929 ELAYLSELPPTPLHVSEDSSS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 ELAYLSELPPTPLHVSEDSSSPER 24 0 Q96EB6;B0QZ35;E9PC49 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 ELAY(0.002)LS(0.011)ELPPT(0.014)PLHVS(0.113)EDS(0.261)S(0.261)S(0.339)PER 50.224 0.026628 2173900.0 613.2 578.4 496.94 651.98 912.89 545.75 663.62 451.22 115.46 377.66 True False 627.4863669205048 510.6806591091351 429.4582774960277 538.1239321803557 830.3192606838197 540.2602505013533 613.5626091164725 439.25217983087765 195.92718713524923 426.1363397199191 1.4725014236826748 1.198397347301531 1.007795481085448 1.2627975650563883 1.9484826410945204 1.2678107923310247 1.4398270035353955 1.0307785065211266 0.45977582494847463 1.0 8.735171275550963 -7.9739979966554255 4.2684063350689545 0.7262474744387091 1.3619568229755599 0.49559221290987265 0.2612668743828997 0.1720897717822365 7.202731902298928 0.17211106527420028 0.07220521872029785 1.0617004546750422e-08 7.9739979966554255 0.6357093485368508 ELDALDANDELTPLGR ddPTM_A459_Selumetinib_30min_R2 2 ELDALDANDELTPLGR 16 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ; 124.07 0.018237 6519100.0 20803.1 20025.8 22720.0 27157.0 24976.0 19509.6 20857.3 19556.0 18193.0 24235.0 False True 19646.946983407503 21561.71446690403 21258.21993566562 23458.169751561978 21838.291591727022 22196.87030948433 21827.205777955875 19612.90472232991 21832.108354892127 23535.272579907964 0.8347873140921291 0.9161446672732078 0.9032493617181957 0.996723945810094 0.9278962679348931 0.943132068435603 0.9274252381759002 0.8333408782812834 0.9276335458094577 1.0 14.522536941622896 -4.580629019422303 1.9778887561386413 0.9286990600444229 0.762042356394563 0.29884044784673225 0.044350603700825046 2.140414351546545 5.615465993723935 0.012144543257146135 0.7832377876787382 2.626461146211867e-05 4.580629019422303 -0.16665670364985996 ELDEEGS(ph)DPPLPGR ddPTM_A459_Selumetinib_30min_R1 4 ELDEEGSDPPLPGR 14 0 C9JQV0;Q9BRJ6;H7C0T1;H7C2R9 C9JQV0 C7orf50 Uncharacterized protein C7orf50 1 ELDEEGS(1)DPPLPGR;ELDEEGS(1)DPPLPGR;ELDEEGS(1)DPPLPGR;ELDEEGS(1)DPPLPGR 201.06 6.303899999999999e-05 83195000.0 12872.2 19406.3 16796.5 19824.8 16283.1 15609.099999999999 16648.699999999997 13642.2 7522.9 11778.7 True False 13172.097215058908 17134.201374255896 14515.627556570269 16362.770837585682 14810.296480014793 15452.086625928854 15392.875155054724 13280.364539889179 12765.811849123224 13290.610879253849 0.9910829031658781 1.289195924094185 1.0921715855234786 1.2311526525185807 1.1143427954190666 1.1626317831672424 1.158176647777901 0.9992290542957161 0.9605135508895368 1.0 13.698119796595126 -7.787057862305756 5.410000630162923 0.9816138995457114 1.1544339167737272 0.489459054788273 0.07563281227186952 0.13659280459957368 10.917574795819677 0.03767267613040222 0.018496955157443564 1.6328343861692615e-08 7.787057862305756 0.17282001722801577 ELDEEGS(ph)DPPLPGR ddPTM_A459_Selumetinib_30min_R2 4 ELDEEGSDPPLPGR 14 0 C9JQV0;Q9BRJ6;H7C0T1;H7C2R9 C9JQV0 C7orf50 Uncharacterized protein C7orf50 1 ELDEEGS(1)DPPLPGR;ELDEEGS(1)DPPLPGR;ELDEEGS(1)DPPLPGR;ELDEEGS(1)DPPLPGR 188.09 7.0942e-05 93036900.0 231898.0 217011.0 247892.0 246828.0 242022.0 175345.0 171021.0 182667.0 167409.0 247545.0 True False 219010.03752124618 233655.04589965456 231942.89860440244 213209.60059794996 211617.03265586798 199497.18212656988 178973.81537168243 183198.5307278503 200895.47779828135 240397.73265084825 0.9110320430489859 0.9719519536359907 0.9648298095276733 0.8869035420879525 0.8802788209455322 0.8298629938258112 0.7444904467199055 0.7620643036343707 0.8356795864213094 1.0 17.875063763544134 -6.30918068507046 1.5416711364158437 0.8147092037520194 0.9494157535776854 0.3114037942649911 0.0683252422050106 0.3831435933683803 1.8179285064564703 0.024942338130900955 0.03270465379821543 4.907036799700415e-07 6.30918068507046 0.134706549825666 ELDEHELDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 ELDEHELDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTPR 43 2 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 ELDEHELDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGT(1)PR 41.868 0.013624 10589000.0 33249.0 25727.0 24328.0 27823.0 21625.0 20600.0 30494.0 22551.0 16647.0 19415.0 True False 31401.153686292713 27700.1781746567 22762.762966323644 24033.459402647884 18908.274170047134 23437.463011818672 31912.031422714685 22616.619676480976 19976.865156042924 18854.438503771948 1.665451542352254 1.4691595387004024 1.2072893585120454 1.2746844408991465 1.0028553311871058 1.243074038356001 1.6925474294198941 1.199538223954873 1.0595311630227773 1.0 14.202616566364973 -5.006958527658738 2.3799900310494513 1.2292037391940371 1.6828704307684708 0.3828036872004892 0.18781013692727183 0.42648884737176684 4.07703987737653 0.05271517301986963 0.3289336051467826 9.841050770056625e-06 5.006958527658738 0.4536666915744336 ELDFSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 2 ELDFSSPGR 9 0 Q4AC94;Q4AC94-2;Q4AC94-4;Q4AC94-1;Q4AC94-3;H7C288;H7BZB4;H0YG44 Q4AC94 C2CD3 C2 domain-containing protein 3 1 ELDFS(0.035)S(0.965)PGR;ELDFS(0.099)S(0.901)PGR 94.409 0.023293 5831900.0 5779.9 6301.4 6536.4 6355.299999999999 6285.9 5463.700000000001 6782.9 6002.5 3197.1000000000004 5171.9 True False 5914.560424272379 5563.629158558616 5648.792781875148 5245.4661587561195 5717.341454865783 5408.740138642683 6271.260392055877 5843.294201132134 5425.245193054789 5835.763743572123 1.0135023767518088 0.9533677857824089 0.967961183846259 0.898848272350608 0.9797074909283677 0.9268264406008913 1.0746254762221032 1.0012903979480503 0.9296547001290953 1.0 12.510705762695782 ELDFSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 ELDFSSPGR 9 0 Q4AC94;Q4AC94-2;Q4AC94-4;Q4AC94-1;Q4AC94-3;H7C288;H7BZB4;H0YG44 Q4AC94 C2CD3 C2 domain-containing protein 3 1 ELDFS(0.08)S(0.92)PGR;ELDFS(0.113)S(0.887)PGR 99.788 0.018495 4969800.0 76971.0 77959.0 79617.0 89278.0 97688.0 78231.0 68909.0 69453.0 67015.0 79839.0 True False 72693.25995932613 83938.20462230574 74494.52890043525 77118.18238685983 85415.56009819952 89006.6101396887 72113.4050405931 69655.0967314369 80419.8725555485 77533.84062336595 0.9375681557224311 1.0826008868830592 0.9608001912649384 0.9946390088100336 1.1016552180501464 1.147971123629148 0.9300894223839169 0.8983831598101607 1.0372228682208837 1.0 16.242538509852928 ELDGERER ddPTM_A459_Selumetinib_30min_R2 1 ELDGERER 8 1 P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A2R8YH90;A0A590UJB9;A0A590UK79;A0A5F9UKJ4 P67936 TPM4 Tropomyosin alpha-4 chain 0 104.44 0.041161 2783400.0 13623.0 21796.0 15392.0 16852.0 16771.0 9299.6 11598.0 16571.0 8286.9 28757.0 False True 12865.888197189863 23467.68311481392 14401.695477542478 14556.728528678506 14664.077045357706 10580.535486636349 12137.329981001005 16619.218866523264 9944.511555332025 27926.71069034095 0.4607018828622665 0.8403310857132459 0.5156960888531571 0.5212475142557073 0.5250914512617338 0.378867944884603 0.4346136612930559 0.5951011936493966 0.35609319212704654 1.0 14.769358037299375 -10.66957493822941 4.552693667659327 1.0000598651550148 0.5204170877842396 0.5610120635255846 0.12881542808313226 188108529.16279727 15.378225555296238 123288.86594472785 0.03185862474179951 2.1400556247817052e-11 10.66957493822941 -0.4796427773707752 ELDPSLVS(ph)ANDSPSGMQTR ddPTM_A459_Selumetinib_30min_R2 1 ELDPSLVSANDSPSGMQTR 19 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ELDPS(0.004)LVS(0.359)ANDS(0.318)PS(0.318)GMQT(0.001)R 93.649 0.0019836 1738100.0 4264.7 4422.4 7275.0 6901.5 8383.0 6006.0 3554.3 5293.6 6640.3 4521.3 True False 4027.6850469467518 4761.5838597427555 6806.934420421097 5961.503794248441 7329.852595029133 6833.271982960329 3719.5819927118373 5309.003499597342 7968.545545483982 4390.758321251818 0.9173096654972452 1.0844559211323692 1.5502867437441692 1.3577389958800554 1.669381928755161 1.5562851523588623 0.8471388586132368 1.2091313415956197 1.8148449453287436 1.0 12.100254411627764 -5.067666215443159 4.740345940965656 1.379626902356899 0.9490647914331513 0.22962841034411552 0.28160822350093934 0.28656045032239685 12.310137976846235 0.07370223309065166 0.2252704304345654 8.557241418447307e-06 5.067666215443159 -0.43056211092374774 ELDPSLVSANDS(ph)PSGMQTR ddPTM_A459_Selumetinib_30min_R1 4 ELDPSLVSANDSPSGMQTR 19 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ELDPSLVS(0.001)ANDS(0.986)PS(0.013)GMQTR;ELDPSLVS(0.002)ANDS(0.941)PS(0.057)GMQTR;ELDPSLVS(0.001)ANDS(0.715)PS(0.284)GMQTR;ELDPSLVSANDS(0.708)PS(0.292)GMQTR 221.9 2.1364e-19 65250000.0 8285.1 14586.5 12320.4 14516.3 11810.7 11949.3 11786.5 9642.2 5320.8 8290.2 True False 8478.126710001747 12878.70579892012 10647.357351112929 11981.30070969922 10742.424270348452 11829.100891096326 10897.434815634408 9386.45753372033 9029.008984143726 9354.327923386309 0.9063319972786059 1.3767644136916222 1.1382279345257909 1.2808296659929297 1.1483908152815372 1.2645591418195803 1.164961812851381 1.003434732093761 0.9652226282949448 1.0 13.191418289124606 -7.747610663035458 3.961968706481207 0.9828918222868485 1.19636657453752 0.36765396375055437 0.11611349074453105 0.2067007999837976 7.144555893249987 0.05899064617031448 0.029452215808453922 1.7880898459921808e-08 7.747610663035458 0.21347475225067158 ELDPSLVSANDS(ph)PSGMQTR ddPTM_A459_Selumetinib_30min_R2 3 ELDPSLVSANDSPSGMQTR 19 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ELDPSLVSANDS(0.5)PS(0.5)GMQT(0.001)R;ELDPSLVS(0.001)ANDS(0.886)PS(0.113)GMQTR;ELDPSLVSANDS(0.5)PS(0.5)GMQTR 263.19 1.4107e-47 47672400.0 111465.0 101446.0 147402.0 145989.0 163736.0 105398.0 102300.0 118761.0 101544.0 124774.0 True False 105270.22152974874 109226.58199969759 137918.31579916284 126105.046354928 143166.01986158776 119915.61779221654 107057.15270360444 119106.574848058 121855.63737641786 121171.4504182148 0.8687708298152406 0.9014217591908793 1.1382080128870902 1.040715828024549 1.1815161027408705 0.9896359033281863 0.8835179601639178 0.982959058730171 1.0056464369770408 1.0 16.88669029542642 -10.356889180362492 14.848421885154302 0.9999999686243958 1.00279841399531 0.0 0.09734316159610891 0.0 0.0 0.1015211752232808 0.0246225016872015 4.39653788306089e-11 10.356889180362492 0.0027984453709141155 ELDPSLVSANDSPS(ph)GMQTR ddPTM_A459_Selumetinib_30min_R1 2 ELDPSLVSANDSPSGMQTR 19 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ELDPS(0.341)LVS(0.015)ANDS(0.151)PS(0.493)GMQTR;ELDPS(0.055)LVS(0.013)ANDS(0.204)PS(0.726)GMQT(0.001)R 197.05 2.9845e-15 59256000.0 10320.8 17535.7 16491.9 19270.3 14982.4 15403.4 15546.1 12426.9 6635.799999999999 10986.2 True False 10561.25455921908 15482.61209187423 14252.39056352224 15905.10385333155 13627.244565357563 15248.455781168195 14373.445160763089 12097.298243739935 11260.467940343724 12396.385784650145 0.851962397967364 1.2489617829614188 1.1497214439042627 1.283043633010041 1.0992917453594846 1.2300727039367905 1.1594867577097385 0.9758730047526791 0.9083670140604229 1.0 13.597631938016443 -7.788727779804192 5.287615911668858 0.952326401720919 1.157328559900382 0.351787149223753 0.11426113737849031 0.18638057265685298 13.72529495490791 0.060086158050776425 0.029405323956463773 1.6265679856325516e-08 7.788727779804192 0.205002158179463 ELDPSLVSANDSPS(ph)GMQTR ddPTM_A459_Selumetinib_30min_R2 2 ELDPSLVSANDSPSGMQTR 19 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 ELDPSLVSANDS(0.06)PS(0.938)GMQT(0.002)R;ELDPSLVS(0.001)ANDS(0.023)PS(0.975)GMQT(0.001)R 164.97 2.6647e-07 44957000.0 110277.0 108797.0 146339.0 166122.0 178374.0 114238.0 115928.0 139335.0 116823.0 142124.0 True False 104148.24581380791 117141.38006250725 136923.7080618558 143495.89702356566 155965.06343620742 129973.2475506864 121318.88170697408 139740.44178184884 140190.8643073471 138020.5108375007 0.7545852799836937 0.8487244348807285 0.9920533349066051 1.0396708152494192 1.130013666011089 0.9416951637261449 0.8789916873283392 1.0124614155817253 1.015724861882316 1.0 17.074523152199163 -5.095440646823143 2.534983596941794 1.0023395926709529 0.7573484450394111 0.6465388824472166 0.06097658810474609 0.21721837506164912 2.5085531030724995 0.018201819784952684 0.08369687008168673 8.027112565047191e-06 5.095440646823143 -0.24499114763154173 ELDQDMVT(ph)EDEDDPGSHK ddPTM_A459_Selumetinib_30min_R2 2 ELDQDMVTEDEDDPGSHK 18 0 Q9NRL2;Q9NRL2-2;A0A087WWN7 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 ELDQDMVT(1)EDEDDPGSHK;ELDQDMVT(0.955)EDEDDPGS(0.045)HK 108.57 0.0020465 9475300.0 47694.0 32908.0 46254.0 52436.0 45711.0 48524.0 59618.0 62789.0 51395.0 43044.0 True False 45043.35841420931 35431.937784102396 43278.06799754743 45294.12634285464 39968.3755184751 55207.74054298489 62390.35513082586 62971.70559472151 61675.436096283185 41801.20787825699 1.0775611686962456 0.847629520354899 1.035330560867803 1.0835602280864831 0.9561536029025792 1.3207211787700839 1.49254909840245 1.50645660235757 1.4754462664310672 1.0 15.351257010247814 -6.848540051781646 4.365587995641038 1.4099112614283653 0.9978287930656804 0.5786395026299815 0.15154629745665085 0.13711506475409677 4.774932495027059 0.0522256077490698 0.04636545547425265 1.4172939988279084e-07 6.848540051781646 -0.4120824683626849 ELDQDMVT(ph)EDEDDPGSHKR ddPTM_A459_Selumetinib_30min_R1 1 ELDQDMVTEDEDDPGSHKR 19 1 Q9NRL2;Q9NRL2-2;A0A087WWN7 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 ELDQDMVT(1)EDEDDPGSHKR 76.04899999999998 0.0049564 27680000.0 6792.1 11251.0 6703.5 6957.0 7919.9 7879.0 9632.5 9100.6 4263.7 7612.1 True False 6950.342714874035 9933.727689552004 5793.201519689749 5742.090549063984 7203.546443371917 7799.744413559616 8905.912769829758 8859.222525085066 7235.187491672985 8589.187183132959 0.8091967920460262 1.1565387361751052 0.6744761053835414 0.6685254875269259 0.8386761505812683 0.9080887687342973 1.0368749195871256 1.031438986739326 0.8423599739310729 1.0 13.068305896544246 -6.950821286900266 3.601469059054497 0.9801118435441678 0.8306968610169968 0.21007102619246565 0.13524168813298051 0.408950133883511 11.009857714223681 0.054415409064764685 0.046101211321994386 1.1198986293211485e-07 6.950821286900266 -0.149414982527171 ELDQDMVT(ph)EDEDDPGSHKR ddPTM_A459_Selumetinib_30min_R2 4 ELDQDMVTEDEDDPGSHKR 19 1 Q9NRL2;Q9NRL2-2;A0A087WWN7 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 ELDQDMVT(1)EDEDDPGSHKR;ELDQDMVT(1)EDEDDPGSHKR;ELDQDMVT(1)EDEDDPGSHKR;ELDQDMVT(1)EDEDDPGSHKR 68.243 0.0098497 107735300.0 572931.0 476222.0 620487.0 675798.0 691278.0 582975.0 683607.0 733910.0 645600.0 513127.0 True False 541089.7886445122 512746.69610492274 580565.5419551658 583753.1465834259 604433.4775362697 663274.5145298535 715396.0800415725 736045.5565946593 774738.0395711717 498311.6902459425 1.0858460662993006 1.0289678250411018 1.1650650653381758 1.1714618741842353 1.2129626684815493 1.331043456360603 1.4356397693349068 1.4770786457596106 1.5547257965969021 1.0 18.926688894057328 -6.506867929138957 1.2161199142369763 1.4069318548636767 1.0862842061231663 0.3942455787459137 0.14316741056399582 0.4000836209492697 1.237240473355737 0.06160943235734275 0.07070357485654127 3.1126627676223394e-07 6.506867929138957 -0.3206476487405103 ELDRYS(ph)LDSEDLYSR ddPTM_A459_Selumetinib_30min_R1 2 ELDRYSLDSEDLYSR 15 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 ELDRYS(0.769)LDS(0.126)EDLYS(0.106)R;ELDRY(0.058)S(0.94)LDS(0.002)EDLYSR 152.9 0.00057857 32761000.0 3369.3 3489.9 3919.7 4343.4 3728.5 2522.13 2950.5 3138.0 1511.35 2355.23 True False 3447.798134483457 3081.300885589508 3387.426269370911 3584.906725715753 3391.2578333201386 2496.7596621108164 2727.941409538822 3054.7700463394663 2564.6505653634085 2657.546712382949 1.2973612536774233 1.159453141964376 1.2746441120252217 1.3489534197128998 1.2760858793256322 0.9394979401404541 1.026488601998176 1.1494699348484219 0.965044397305723 1.0 11.375879335263601 -6.749569446350522 24.999166997047958 1.0260913259266056 1.2695858399694913 0.7776890047022942 0.06811468438530362 112.23784994831618 236382.82429107872 0.023465248934996328 0.023284234058127427 1.7800432462653205e-07 6.749569446350522 0.2434945140428857 ELDRYS(ph)LDSEDLYSR ddPTM_A459_Selumetinib_30min_R2 1 ELDRYSLDSEDLYSR 15 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 ELDRY(0.017)S(0.645)LDS(0.338)EDLYSR 81.357 0.015088999999999997 12177000.0 20992.0 18651.0 19997.0 19361.0 20556.0 18722.0 18320.0 15841.0 19737.0 21973.0 True False 19825.348677634112 20081.471727582768 18710.414791087387 16723.9984004121 17973.571507028388 21300.785558605283 19171.91630039133 15887.094687381274 23684.95149785662 21338.582397289767 0.9290846181118455 0.9410874327871628 0.8768349482046105 0.7837445847638047 0.8423039156205253 0.9982287090125872 0.8984625099944021 0.7445243733435221 1.1099589961920275 1.0 14.381176715208852 -8.278517954603071 24.999612420884205 1.0549795180859003 0.8794491748125816 0.47751096291674877 0.0745179323434315 850.5826299850221 1245070.2390581185 0.0730774496812916 0.0190596116619446 5.266014436862551e-09 8.278517954603071 -0.17553034327331873 ELDRYSLDS(ph)EDLYSR ddPTM_A459_Selumetinib_30min_R1 1 ELDRYSLDSEDLYSR 15 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 ELDRYS(0.145)LDS(0.854)EDLYS(0.001)R 124.98 0.00069805 18094000.0 3079.8 2942.1 3188.7 3460.3 3017.1 2392.4 2594.1 2709.9 1163.0 1991.5 True False 3151.553347752398 2597.6375642548164 2755.6920542753337 2856.0235628756795 2744.203837712268 2368.3346281254007 2398.424948478107 2638.024649004243 1973.5260578407665 2247.128423852719 1.4024803007693862 1.1559809117634436 1.226317118783393 1.2709658836405109 1.22120472002544 1.0539382631567058 1.0673288286594627 1.1739536650430193 0.8782435560390184 1.0 11.133866861855054 -6.956981492582709 0.519761755370289 0.9709793796180702 1.2987148657804477 0.6288213194952581 0.0866008372124343 0.6744440338169048 0.3902360611734858 0.07856604115811555 0.08521462201842805 1.1041256711080807e-07 6.956981492582709 0.32773548616237747 ELDRYSLDS(ph)EDLYSR ddPTM_A459_Selumetinib_30min_R2 1 ELDRYSLDSEDLYSR 15 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 ELDRY(0.092)S(0.342)LDS(0.565)EDLYSR 87.35600000000002 0.010306999999999998 12567000.0 16901.0 15001.0 15241.0 18402.0 16565.0 14819.0 15434.0 18210.0 16296.0 19052.0 True False 15961.710080063545 16151.52846418258 14260.410653146108 15895.615854779373 14483.956607021062 16860.18273651169 16151.711581890815 18262.98808517222 19555.65534828352 18501.919256959212 0.8627056392573864 0.8729650281068777 0.7707530475673368 0.8591333490335323 0.7828353591789211 0.9112666908958644 0.8729749253346026 0.9870861412554742 1.056952799149632 1.0 14.175387312933156 -7.711098480201763 1.551506055855204 1.0344510961130378 0.8363455103259778 0.781504861668 0.04108248540917252 0.17523051410025173 0.7996945186806176 0.03069562713903773 0.012496456497138798 1.944919003640381e-08 7.711098480201763 -0.19810558578705995 ELEAENYHDIKR ddPTM_A459_Selumetinib_30min_R2 1 ELEAENYHDIKR 12 1 A0A087WUZ3;Q01082;Q01082-2;F8W6C1;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 89.805 0.017056 3586800.0 24594.0 26973.0 30821.0 26333.0 25312.0 16489.0 18671.0 19692.0 15433.0 22771.0 False True 23227.163937582573 29041.74236813525 28838.010415367517 22746.39997304126 22132.080267848913 18760.210077761072 19539.238495884623 19749.300459813916 18520.03123404882 22113.542063836758 1.0503592717318213 1.3133012470050414 1.3040882519914154 1.0286185680872646 1.0008383190697645 0.8483584413390048 0.8835870092398266 0.8930862546941681 0.8374972756777593 1.0 14.432642508667868 -6.1053549513036955 1.9944467570487479 0.8920671626704049 1.2290149880976213 0.7168637402326874 0.08675383027622609 0.16316375426187305 1.283737422170469 0.028140982535306707 0.04119883922116216 7.845941193365138e-07 6.1053549513036955 0.33694782542721646 ELEAIFGRPVVDGEEGEPHS(ph)ISPR ddPTM_A459_Selumetinib_30min_R1 3 ELEAIFGRPVVDGEEGEPHSISPR 24 1 P36507;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 ELEAIFGRPVVDGEEGEPHS(0.691)IS(0.309)PR;ELEAIFGRPVVDGEEGEPHS(0.5)IS(0.5)PR;ELEAIFGRPVVDGEEGEPHS(0.799)IS(0.201)PR 100.57 2.2891e-06 55168400.0 7882.5 10507.400000000001 7413.2 6527.4 9128.900000000001 7789.2 10154.9 10893.5 6017.9 8499.1 True False 8066.14691332498 9277.188723242261 6406.528157792798 5387.512124473229 8303.192606838204 7710.847720027743 9388.90771724311 10604.568992925104 10211.93676997416 9590.042273244611 0.8410960748138548 0.9673772501634134 0.6680396160157143 0.5617818953211418 0.8658139735216176 0.8040473128612103 0.97902672894752 1.1057895982910246 1.0648479411258258 1.0 13.227321459370138 -7.327300620643052 2.263359375081041 1.0654136408745212 0.7750299589662997 0.5824256379648302 0.1062463533613739 0.24199383610944988 2.4233527369879693 0.058531082484791816 0.036289633525952936 4.706514265274947e-08 7.327300620643052 -0.2903836819082215 ELEAIFGRPVVDGEEGEPHS(ph)ISPR ddPTM_A459_Selumetinib_30min_R2 2 ELEAIFGRPVVDGEEGEPHSISPR 24 1 P36507;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 ELEAIFGRPVVDGEEGEPHS(0.887)IS(0.113)PR;ELEAIFGRPVVDGEEGEPHS(0.707)IS(0.293)PR 72.058 0.00044035 24872000.0 61493.0 41572.5 46480.3 54211.0 56542.0 44147.0 53510.2 60713.3 51417.6 47633.0 True False 58075.46523598298 44760.97707334378 43489.80810192426 46827.36828080885 49438.68846810655 50227.84852343488 55998.53032844978 60889.9656513721 61702.55672777993 46257.711524603066 1.2554764021366343 0.9676435689979342 0.9401634164023301 1.0123148495122332 1.0687664140456152 1.0858264896377379 1.210577187733679 1.3163203203207876 1.3338869281279127 1.0 15.497406273846657 -7.201933682904411 2.4553798133758282 1.2473608754354555 1.037403585316982 0.3012698218856512 0.11708034726280585 0.31059958163930806 3.672514256925092 0.05274176830936288 0.036564152645752176 6.281542711220962e-08 7.201933682904411 -0.20995729011847342 ELEAIFGRPVVDGEEGEPHSIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ELEAIFGRPVVDGEEGEPHSISPR 24 1 P36507;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 ELEAIFGRPVVDGEEGEPHS(0.437)IS(0.563)PR;ELEAIFGRPVVDGEEGEPHS(0.321)IS(0.679)PR 94.929 5.1553e-06 79660000.0 5416.9 7494.099999999999 5846.0 4906.13 6619.799999999999 5839.5 6690.3 7292.1 3570.8100000000004 6653.799999999999 True False 5543.103230547424 6616.687288087429 5052.14530977941 4049.3664949661174 6021.040258820617 5780.759931841777 6185.645284608567 7098.68981992097 6059.403768356313 7507.880043500493 0.7383047143042782 0.88129901513483 0.672912364143725 0.5393488536716325 0.8019627676434414 0.7699590161734311 0.8238870691552173 0.9454985666781189 0.8070725335578431 1.0 12.87418988448065 -7.353193295608892 1.3375632010200509 0.915957930429877 0.7217863710874939 0.4407500115220738 0.09375173900737978 0.4717411990395698 1.6273869489580144 0.06514035932188553 0.03498277452942581 4.434112467111416e-08 7.353193295608892 -0.19417155934238317 ELEAIFGRPVVDGEEGEPHSIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ELEAIFGRPVVDGEEGEPHSISPR 24 1 P36507;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 ELEAIFGRPVVDGEEGEPHS(0.432)IS(0.568)PR;ELEAIFGRPVVDGEEGEPHS(0.103)IS(0.897)PR 102.67 1.2219e-06 36893000.0 49432.0 33223.0 41491.0 47530.0 52659.0 42125.0 43833.0 49699.0 47409.0 44711.0 True False 46684.7673319745 35771.09727121777 38821.51423198513 41056.33200617669 46043.50564256703 47927.33637732336 45871.32135344174 49843.61586188761 56892.124718137755 43420.077256870856 1.0751884907018916 0.8238377158934533 0.894091320987734 0.9455610077174582 1.0604197079193598 1.1038058751896684 1.0564541624850055 1.147939363788218 1.3102723051727196 1.0 15.406074672476374 -6.484496056030365 1.4163424326169605 1.1396585874815715 0.9166320346660414 0.46648437077863036 0.09501054260461855 0.34693960047118605 1.4250019374158205 0.03892737189099757 0.04467874881730167 3.2772075293055045e-07 6.484496056030365 -0.22302655281553008 ELEDATETADAMNR ddPTM_A459_Selumetinib_30min_R1 3 ELEDATETADAMNR 14 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;; 296.65 1.192599999999999e-109 61483000.0 5355.2 5522.5 6478.280000000001 6973.5 6557.400000000001 6113.1 5754.799999999999 5038.93 3434.3599999999997 4354.219999999999 False True 5479.965740594725 4875.923132659403 5598.565158644844 5755.709133807341 5964.284327803002 6051.607764250702 5320.710802783939 4905.281207648605 5827.858084270003 4913.1265506944455 1.1153723976070105 0.9924277509135635 1.1395116940054222 1.1714962100851647 1.2139488503425544 1.2317223466176213 1.0829582238283446 0.9984031872647914 1.1861811463916525 1.0 12.262425684692996 -9.485329131756478 0.6179982204116645 0.9943281354600731 1.1300712721687882 0.17825421900100102 0.07856430547042427 8.065286069411524 3.643077444692616 0.22276057114807382 0.03466064606208082 3.2709271244351384e-10 9.485329131756478 0.13574313670871507 ELEDATETADAMNR ddPTM_A459_Selumetinib_30min_R2 3 ELEDATETADAMNR 14 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;; 272.15 2.5672000000000002e-42 26104300.0 53407.1 44701.5 54475.8 56997.1 56619.1 49324.5 47090.6 47382.4 41301.7 54005.8 False True 50438.9471875606 48129.96131202304 50970.886336766394 49233.99665451827 49506.1024768238 56118.50215176936 49280.406208253706 47520.274939421426 49563.19406591809 52446.512230080145 0.9617216673300895 0.9176961301235702 0.9718641749361663 0.9387468214956081 0.943935075408696 1.0700139964613926 0.9396317145373386 0.9060712127234015 0.9450236432975164 1.0 15.678559214207587 -4.4093697030549 20.653896741645887 0.9573126310882812 1.9364187705994655 0.0 0.04462957435268791 8640.498349681466 1545144.0709067888 0.011092990645328607 6896.1055659050235 3.896101809405426e-05 4.4093697030549 0.9791061395111843 ELEEEAEEEQR ddPTM_A459_Selumetinib_30min_R2 1 ELEEEAEEEQR 11 0 Q9H2J4 Q9H2J4 PDCL3 Phosducin-like protein 3 0 145.46 0.036412 0.0 5336.8 4523.4 2938.8 6610.7 5638.0 4091.8 4731.3 3934.6 3920.2 4821.2 False True 5040.202020903091 4870.330234976566 2749.7208075235076 5710.311255906427 4929.704035640492 4655.4083083378455 4951.314824893093 3946.0490345919047 4704.349539539826 4681.999429018043 1.0765063296814996 1.040224440180682 0.587296271435088 1.2196309167649881 1.0529057319159905 0.9943205630236964 1.0575214499612902 0.8428127970574124 1.0047736252130364 1.0 12.192909043171626 -5.016743721405055 24.924291029806415 0.9690832249742484 1.0674360705634038 0.05126015879065282 0.1556521832524542 2048.8715929010755 3049928.3455949076 0.03944530159381546 0.11071443102106168 9.621798963960461e-06 5.016743721405055 0.09835284558915547 ELEEEEENS(ph)DEDELDSHTMVK ddPTM_A459_Selumetinib_30min_R1 3 ELEEEEENSDEDELDSHTMVK 21 0 A0A087WZ06;Q13188;Q13188-2;E5RFQ9 A0A087WZ06 STK3 Serine/threonine-protein kinase 3;Serine/threonine-protein kinase 3 36kDa subunit;Serine/threonine-protein kinase 3 20kDa subunit 1 ELEEEEENS(1)DEDELDSHTMVK;ELEEEEENS(1)DEDELDSHTMVK;ELEEEEENS(0.99)DEDELDS(0.004)HT(0.006)MVK 181.13 1.525e-14 124048200.0 9573.2 10906.8 11599.82 12014.41 12206.02 10091.77 10267.650000000001 10227.39 5845.29 8678.65 True False 9796.23693379546 9629.82678556624 10024.62815725032 9916.318831907405 11101.987646147865 9990.255956394025 9493.152893967565 9956.12639395532 9919.030206909767 9792.63926470972 1.0003673850316028 0.9833739940028 1.0236901295217349 1.0126298502226458 1.1337074047194526 1.0201801257395917 0.9694171956459755 1.0166948995900182 1.0129067291037186 1.0 13.257482025078591 -5.276576306282837 18.45090268723641 1.0257253855593944 0.9918707748680773 0.08951741249421774 0.04011130177333263 57.92863975568826 70616.39524145433 0.01126061319591696 0.023787397879771622 5.289610496836862e-06 5.276576306282837 -0.03385461069131712 ELEEEEENS(ph)DEDELDSHTMVK ddPTM_A459_Selumetinib_30min_R2 8 ELEEEEENSDEDELDSHTMVK 21 0 A0A087WZ06;Q13188;Q13188-2;E5RFQ9 A0A087WZ06 STK3 Serine/threonine-protein kinase 3;Serine/threonine-protein kinase 3 36kDa subunit;Serine/threonine-protein kinase 3 20kDa subunit 1 ELEEEEENS(1)DEDELDSHTMVK;ELEEEEENS(1)DEDELDSHTMVK;ELEEEEENS(0.999)DEDELDS(0.001)HTMVK;ELEEEEENS(1)DEDELDSHTMVK;ELEEEEENS(0.721)DEDELDS(0.265)HT(0.014)MVK;ELEEEEENS(0.849)DEDELDS(0.141)HT(0.01)MVK;ELEEEEENS(0.881)DEDELDS(0.01)HT(0.109)MVK;ELEEEEENS(0.992)DEDELDS(0.006)HT(0.002)MVK 124.1 4.728e-05 157325900.0 287251.1 270233.5 315536.5 326899.2 319475.7 255145.2 267084.9 285497.1 249356.2 283560.7 True False 271286.8338192621 290959.54051234404 295235.2251201657 282374.96502742666 279340.30641700496 290289.1353224794 279504.87706868886 286327.84929441044 299234.40759435773 275373.5658118219 0.985159316289086 1.0565993858363765 1.0721262378608858 1.0254250955241986 1.014404943312147 1.0541648558992411 1.015002570216526 1.0397797205054686 1.0866489915696602 1.0 18.071030550603332 -8.009245510447638 24.89463971352515 1.0499544459090455 1.0337910718430279 0.012251669724741232 0.03067686187634537 1461.6774688347891 3935735.6250323094 0.017853900003844344 0.0077127739750958366 9.789364276816562e-09 8.009245510447638 -0.016163374066017644 ELEELS(ph)LEAQGIK ddPTM_A459_Selumetinib_30min_R1 1 ELEELSLEAQGIK 13 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 ELEELS(1)LEAQGIK 144.8 0.00064995 4603000.0 1624.5 1564.9 1639.8 1280.9 1547.8 1555.6 1696.9 1715.3 926.79 1917.5 True False 1662.3476892732535 1381.6807804977268 1417.1241667766453 1057.2148604709007 1407.8017632862852 1539.9520763717912 1568.9014668179732 1669.8046719203574 1572.6949399365803 2163.6298030316793 0.768314286919126 0.6385938937251256 0.6549753404168172 0.4886301986548395 0.6506666534698646 0.7117447144673315 0.7251247254126503 0.7717608019544869 0.726878016624156 1.0 11.079237959881164 -8.94081399253012 0.4900439699964316 1.0154817888084893 0.6363255217412948 0.6759434504841331 0.07026347578914283 1.0796066140113163 0.5029754371656493 0.11751975535053288 0.040834457492860875 1.1460036674596278e-09 8.94081399253012 -0.3791562670671945 ELEEVS(ph)PETPVVPATTQR ddPTM_A459_Selumetinib_30min_R1 4 ELEEVSPETPVVPATTQR 18 0 Q15149 Q15149 PLEC Plectin 1 ELEEVS(1)PETPVVPATTQR;ELEEVS(0.999)PET(0.001)PVVPATTQR;ELEEVS(1)PETPVVPATTQR;ELEEVS(1)PETPVVPATTQR 317.7 7.036099999999997e-127 65936200.0 10402.800000000001 12176.1 10054.8 10447.3 11141.6 9285.599999999999 10273.900000000001 10357.7 5342.3099999999995 9435.1 True False 10645.16499967486 10750.516551484687 8689.413387062943 8622.87517510941 10133.844247209241 9192.195294650235 9498.931451435663 10082.98014944879 9065.509883115481 10646.186990656694 0.9999040040361182 1.0097997114760011 0.8161995834460681 0.809949626347632 0.9518754701662582 0.8634260606842139 0.892237893226196 0.9470977879965676 0.8515264564741868 1.0 13.37804919078308 -5.238409622909287 24.47366664386986 0.8879116244507299 1.0048519099139817 0.3798364726782537 0.05776675111181238 601.4460286323284 639152.0806920851 0.01440563449055639 0.03805079645267842 5.775510491264146e-06 5.238409622909287 0.11694028546325175 ELEEVS(ph)PETPVVPATTQR ddPTM_A459_Selumetinib_30min_R2 3 ELEEVSPETPVVPATTQR 18 0 Q15149 Q15149 PLEC Plectin 1 ELEEVS(0.904)PET(0.096)PVVPATTQR;ELEEVS(0.923)PET(0.077)PVVPATTQR;ELEEVS(1)PETPVVPATTQR 216.77 3.5148e-14 49717000.0 121023.0 109588.0 137327.0 143516.0 167536.0 126480.0 110429.0 133864.0 130555.0 113733.0 True False 114297.0261534544 117993.04721904121 128491.53033033208 123968.87322109127 146488.6298891569 143901.47192887482 115564.16731091228 134253.52207762166 156669.64801148497 110449.23277617783 1.034837665057158 1.0683011937090654 1.163353760824364 1.1224059244694855 1.3262983020082346 1.3028743460852008 1.046310276732295 1.2155224504789683 1.418476562249839 1.0 16.753023871637488 -5.420730368341532 1.3710568492071655 1.2202386881754708 1.030340158703067 0.2088826403174383 0.11966871396185565 0.8328635433266717 2.7115409913420017 0.03776012564114615 0.15761766575744024 3.7955055573989047e-06 5.420730368341532 -0.18989852947240382 ELEEVSPET(ph)PVVPATTQR ddPTM_A459_Selumetinib_30min_R1 1 ELEEVSPETPVVPATTQR 18 0 Q15149 Q15149 PLEC Plectin 1 ELEEVS(0.256)PET(0.723)PVVPAT(0.021)T(0.001)QR 154.52 9.9494e-05 2787600.0 828.21 698.09 367.48 481.92 798.5 544.48 684.13 436.03 317.9 399.22 True False 847.5056815838728 616.3572982667636 317.5782344231504 397.7617187587916 726.2758159866252 539.0030255482854 632.5255233037774 424.4650679749514 539.4530815026478 450.4637757321029 1.881406957099912 1.368272725737041 0.705002824937512 0.8830048944831161 1.6122846166848088 1.19655132018615 1.4041651235458035 0.9422845761240227 1.1975504148494909 1.0 8.815267285440889 -4.850124786728363 3.7810290257537855 1.1328142251982878 1.907482174763934 0.46360831298841043 0.24864603928838136 0.21978453745044285 5.272265104527914 0.06578362615853914 0.4112457515202907 1.4121317356032432e-05 4.850124786728363 0.7746679495656461 ELEEVSPET(ph)PVVPATTQR ddPTM_A459_Selumetinib_30min_R2 1 ELEEVSPETPVVPATTQR 18 0 Q15149 Q15149 PLEC Plectin 1 ELEEVS(0.247)PET(0.753)PVVPATTQR 142.74 0.00069916 10088000.0 20632.0 20644.0 25110.0 27246.0 34529.0 20239.0 21704.0 24261.0 22929.0 24574.0 True False 19485.356036439927 22227.328419077738 23494.44993770087 23535.047798028423 30191.158326823443 23026.738538650385 22713.279005660108 24331.595493375236 27515.44068978846 23864.484769080187 0.8165001769359781 0.9313977919136299 0.9844943297557066 0.9861955129457227 1.2651083238947758 0.9648956917136036 0.9517607115946778 1.0195734678043524 1.152986999553353 1.0 14.542577568689746 -4.971357118385667 1.247706938758403 1.0496016906013 0.765178929008227 0.399411266315263 0.09034635694040441 1.1426793926574013 1.9556829815079677 0.028789601974370055 0.38484143061431947 1.0681761615692205e-05 4.971357118385667 -0.2844227615930729 ELEEWYAR ddPTM_A459_Selumetinib_30min_R1 3 ELEEWYAR 8 0 P09496-2;F8WF69;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 ;; 148.38 0.021819 46476000.0 8890.5 9611.5 9493.2 9715.5 9978.0 8029.0 9039.3 8780.900000000001 4678.4 7258.1 False True 9097.631352098413 8486.181111734879 8204.075582414967 8018.870307522086 9075.491661758979 7948.235549748722 8357.458323417815 8548.002007617019 7938.903103183357 8189.74783488096 1.1108561014968845 1.036195653740568 1.00174947358855 0.9791351906305235 1.1081527593689207 0.970510412530211 1.0204781016361162 1.0437442250920375 0.9693708845797144 1.0 12.999603316141632 -4.786519212109001 3.1161193759589487 1.014452224340096 1.124978521764091 0.36633791436632057 0.03908336028030848 0.3829098664473408 5.589764566074833 0.009596644102855753 0.10485947576959838 1.6348608273484638e-05 4.786519212109001 0.11052629742399511 ELEEYRR ddPTM_A459_Selumetinib_30min_R1 1 ELEEYRR 7 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;H0YG19 P35611 ADD1 Alpha-adducin 0 108.09 0.022215 2639600.0 1612.9 1986.4 1404.9 1566.2 1717.6 1665.7 1678.1 1721.6 1114.5 1502.4 False True 1650.4774318429252 1753.8313645476937 1214.1222965633067 1292.6925712151801 1562.24338326691 1648.9445703345923 1551.5195659539397 1675.9375754550742 1891.2251001406155 1695.2476746152788 0.9735907363609781 1.0345575993464848 0.7161916897121483 0.7625390617383062 0.9215428557490557 0.9726865254121675 0.9152170442033156 0.9886092755357492 1.1156040078744316 1.0 10.727280350257281 -7.620430831453804 1.179071796744032 1.0540634091448404 0.8815110974344978 0.311447515657174 0.09478333758383142 0.6549867312679593 1.678911456749629 0.08383944322820429 0.036001373852808674 2.396454394169177e-08 7.620430831453804 -0.17255231171034258 ELEEYRR ddPTM_A459_Selumetinib_30min_R2 2 ELEEYRR 7 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;H0YG19 P35611 ADD1 Alpha-adducin 0 ; 97.071 0.030764 8276500.0 46933.0 41475.0 44602.0 44324.0 55963.0 38351.0 40202.0 38075.0 32785.0 39905.0 False True 44324.65174768489 44655.99913685569 41732.35587898579 38286.9947368352 48932.42762443223 43633.50213428434 42071.47265875174 38185.79194634444 39342.91608943757 38752.83896435845 1.1437781832822858 1.152328457224165 1.0768851262063057 0.9879790941780627 1.2626798173273472 1.1259433708692852 1.085635885862336 0.9853676005895844 1.015226681214809 1.0 15.24201438309177 -7.62060336609172 3.652324203076171 1.0001807532797256 1.1231530929884088 0.42536428975952756 0.06464042305789222 0.24376453213133856 6.269910993301041 0.0349299741034398 0.018866836634813314 2.395502530196195e-08 7.62060336609172 0.12297233970868326 ELEKPIQSKPQS(ph)PVIQAAAVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ELEKPIQSKPQSPVIQAAAVSPK 23 2 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 2 ELEKPIQS(0.038)KPQS(0.962)PVIQAAAVS(1)PK 61.177 0.026813 14723000.0 66709.0 44660.0 51733.0 49807.0 40522.0 30972.0 50980.0 42258.0 26864.0 41346.0 True False 63001.58083728533 48085.27839546659 48404.55510263155 43023.20067813259 35431.26408872369 35238.11186417705 53350.671014953594 42380.9637838115 32237.55064287482 40152.23355019083 1.5690679015037234 1.1975741856392457 1.205525840601749 1.0715020529145163 0.882423241646922 0.8776127440115863 1.3287099196677201 1.0555070051292346 0.8028831223692064 1.0 15.29319262238937 ELEKPIQSKPQSPVIQAAAVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ELEKPIQSKPQSPVIQAAAVSPK 23 2 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 ELEKPIQSKPQSPVIQAAAVS(1)PK;ELEKPIQSKPQS(0.001)PVIQAAAVS(0.999)PK 140.19 3.2696e-06 225325000.0 6168.0 7843.2 8550.9 9879.7 6288.099999999999 7941.0 6236.5 7092.799999999999 4399.799999999999 6313.2 True False 6311.702399161242 6924.914497795244 7389.7347467315685 8154.395859937821 5719.34246525422 7861.120749851117 5766.075783965048 6904.675903338611 7466.139251322277 7123.560715775539 0.8860319510134321 0.9721141959890393 1.0373653067021062 1.144707848405003 0.8028769169592959 1.10353811296115 0.8094373044642882 0.9692731175924147 1.0480909125668119 1.0 12.798382838059451 -6.251198949700968 24.983622189496117 0.9540948766744236 1.009295507504338 0.05926428652710458 0.10630129827152636 2365.2181430645387 5770429.145958032 0.031018619409988905 0.03957099093382729 5.607910195914946e-07 6.251198949700968 0.05520063082991433 ELEKPIQSKPQSPVIQAAAVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 ELEKPIQSKPQSPVIQAAAVSPK 23 2 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 ELEKPIQSKPQSPVIQAAAVS(1)PK;ELEKPIQSKPQSPVIQAAAVS(1)PK;ELEKPIQSKPQSPVIQAAAVS(1)PK;ELEKPIQSKPQSPVIQAAAVS(1)PK 119.87 4.1605e-06 141091000.0 740539.0 574600.0 625958.0 630102.0 576730.0 496936.0 572769.0 562998.0 377894.0 638153.0 True False 699382.8069924968 618669.9723697965 585684.5437715382 544281.0206134232 504276.02136838314 565384.4232641326 599403.8934202426 564636.230970664 453483.35924056487 619727.8647693837 1.1285321295868385 0.998292972674416 0.9450673062594759 0.8782581057831954 0.8137055795547242 0.912310798667293 0.9672050064156722 0.9111035069897644 0.7317459566051906 1.0 19.241275311974718 -4.831570933910544 1.301903647719096 0.8861879639043627 1.2174567294458667 0.5207409110463063 0.07152600071447966 1.010638884350967 1.6063681871831097 0.02145127883146117 0.4385568736644288 1.4737678088068761e-05 4.831570933910544 0.331268765541504 ELELMFGCQVEGDAAET(ph)PPRPR ddPTM_A459_Selumetinib_30min_R1 1 ELELMFGCQVEGDAAETPPRPR 22 1 H3BRW9;Q02750-2;Q02750 H3BRW9 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1 ELELMFGCQVEGDAAET(1)PPRPR 96.533 0.00027374 6885100.0 1228.1 1627.3 1641.3 1641.7 1804.3 1184.2 1121.7 1367.4 701.15 1232.5 True False 1256.7123405333846 1436.774959488754 1418.420475015557 1355.0079135257072 1641.101383575037 1172.2880231675713 1037.0892659141489 1331.1321100588225 1189.8003400301413 1390.703380566647 0.9036523230577989 1.033128256942422 1.01993027042015 0.9743327962384074 1.1800513369762318 0.8429461231984051 0.7457300243935434 0.9571646467965355 0.8555385401776712 1.0 10.441599028756142 -6.81029239677779 24.999884553964172 0.8691893242263918 1.0200384333204167 0.3764378736502042 0.09076271331769536 115.5585351006006 59134.696002651384 0.03132743262530424 0.02762825216339853 1.5477742004829925e-07 6.81029239677779 0.15084910909402482 ELENLS(ph)PEEAAHQK ddPTM_A459_Selumetinib_30min_R2 2 ELENLSPEEAAHQK 14 0 U3KQS6;A0A0A0MQU7;F5H0K0;A0A0A0MTK8;P20823-3;P20823-2;P20823;P20823-7;A0A087WYP0;H0YND5;E0YMI9;P20823-8;P20823-5;P20823-4 U3KQS6 HNF1A Hepatocyte nuclear factor 1-alpha 1 ELENLS(1)PEEAAHQK;ELENLS(1)PEEAAHQK 102.84 0.0048333 3822900.0 28370.0 27059.0 35277.0 32149.0 37853.0 31111.0 26781.0 27056.0 30205.0 30662.0 True False 26793.308974108208 29134.338291601638 33007.31622669348 27770.25073988165 33097.5677298864 35396.25785246068 28026.36956554474 27134.72848063809 36246.843998214485 29776.708390556527 0.8998076154920306 0.9784270950795014 1.108494457942219 0.9326165396000852 1.1115254008526698 1.188722990741527 0.9412178538321283 0.9112736077048622 1.2172884767112109 1.0 14.861896662311509 -4.961585707036998 3.774482650089002 1.0472868183054216 0.9048581382184184 0.182672010827298 0.10109257089110195 0.40272747224588706 11.84579035854101 0.02578265226549011 0.1228370511795199 1.092482007052164e-05 4.961585707036998 -0.14242868008700316 ELEPGCGS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 ELEPGCGSPGR 11 0 A6NIX2 A6NIX2 WTIP Wilms tumor protein 1-interacting protein 1 ELEPGCGS(1)PGR 119.21 0.0050849 10577000.0 31041.0 32643.0 35639.0 35454.0 43133.0 41086.0 37124.0 25185.0 27832.0 35447.0 True False 29315.86548696839 35146.61313621171 33346.025540809285 30625.104038438654 37714.24692608751 46745.223558426274 38850.339559810454 25258.284180398816 33399.17769105466 34423.55300763346 0.8516223029176437 1.0210048082026253 0.968697959022846 0.889655522532712 1.0955942554135631 1.357943020816604 1.1285976073183193 0.7337500627781729 0.9702420224794447 1.0 15.071108391568767 -4.761393106140937 13.82614690685828 1.0209644768049186 0.8515373019263537 0.09561184431351899 0.15368385605707446 0.15410111272048096 3618.4105986412196 0.04223019151914384 0.23594366520621166 1.732235337189656e-05 4.761393106140937 -0.16942717487856496 ELEQHIQT(ph)SDPENFQSEER ddPTM_A459_Selumetinib_30min_R2 1 ELEQHIQTSDPENFQSEER 19 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 1 ELEQHIQT(0.864)S(0.136)DPENFQSEER 173.45 1.9377e-09 22028000.0 39159.0 31316.0 39607.0 41348.0 43539.0 28581.0 34952.0 31072.0 30132.0 35391.0 True False 36982.69954589719 33717.836503189224 37058.72874084102 35716.33107072155 38069.24157640146 32517.77331751405 36577.337256074105 31162.414375753473 36159.241958424056 34369.16987313895 1.0760428512648141 0.9810489059714308 1.0782549848492 1.0391967918502294 1.1076567085245281 0.9461320549068062 1.0642484933760632 0.9066967427720244 1.0520836578797945 1.0 15.068827385918699 -6.766611075447779 24.99999865183476 0.9924017632433383 1.052505632855098 0.25883114199020973 0.0527349260936519 183.80694812175884 888517.4479172074 0.017166234785894505 0.01559611365439 1.7115473742153177e-07 6.766611075447779 0.06010386961175962 ELEQHIQTS(ph)DPENFQSEER ddPTM_A459_Selumetinib_30min_R1 1 ELEQHIQTSDPENFQSEER 19 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 1 ELEQHIQT(0.212)S(0.788)DPENFQSEER 150.64 1.6934e-05 10605000.0 4318.3 4616.2 4315.6 4662.4 5180.3 4316.5 4600.7 4574.1 2612.6 4216.0 True False 4418.907988050907 4075.733157986843 3729.5652238939488 3848.1993640873825 4711.74277965625 4273.079929068421 4253.66549495518 4452.780009229241 4433.391383245734 4757.164667317632 0.9288953183414914 0.8567567959099006 0.783989095335835 0.8089270885502525 0.9904518992219384 0.8982409119501499 0.8941598183847703 0.936015530389445 0.9319398619315693 1.0 12.215886249128083 -6.252185946020871 24.99635652387338 0.9340420170119829 0.8411750548449158 0.4953852532498536 0.04760352758046003 624.6458155854733 1687358.2121200438 0.01464291882118445 0.018643360789407527 5.595179889190945e-07 6.252185946020871 -0.09286696216706702 ELEQHIQTS(ph)DPENFQSEER ddPTM_A459_Selumetinib_30min_R2 1 ELEQHIQTSDPENFQSEER 19 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 1 ELEQHIQT(0.058)S(0.942)DPENFQSEER 115.31 0.00031462 20119000.0 51004.0 45745.0 50606.0 51954.0 54402.0 39407.0 40181.0 44673.0 46315.0 46846.0 True False 48169.40186518915 49253.49440664171 47350.06505564675 44877.775574351035 47567.534399949305 44834.956548870745 42049.49611714102 44802.99103398672 55579.29414922377 45493.43425947467 1.058820962832833 1.082650611200757 1.0408109615462897 0.986467087061131 1.0455911973724576 0.9855258737590955 0.9242981278860828 0.9848232335780596 1.2216992419658574 1.0 15.473370726073933 -3.698865023600104 13.159664458812848 1.0289508051119547 1.0327647236261892 0.0 0.0766639334173309 0.0 0.0 0.01767346535731546 0.0 0.00020004835125918258 3.698865023600104 0.0038139185142345156 ELES(ph)PLTPGK ddPTM_A459_Selumetinib_30min_R1 3 ELESPLTPGK 10 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 ELES(0.941)PLT(0.059)PGK;ELES(0.858)PLT(0.142)PGK;ELES(0.999)PLT(0.001)PGK 156.58 0.00050635 76877600.0 15306.3 20682.2 14195.999999999998 15098.2 13757.6 15504.6 18231.4 18151.5 10547.400000000001 15280.400000000001 True False 15662.907009124785 18260.718409106077 12268.261173046272 12461.582798315058 12513.227509101553 15348.637801050449 16856.190819815663 17670.06325561848 17898.167448383243 17241.788183700275 0.908427063495183 1.059096551619226 0.7115422740574099 0.7227546624250819 0.7257499846176673 0.8901998816781929 0.977635883251997 1.0248393651142913 1.0380690945561832 1.0 14.073621786805544 -7.228322224717224 2.779007242586412 1.018716768862006 0.8257954633380922 0.4385492477215839 0.09858617138402404 0.299706463384884 4.605126097099577 0.04959094020296302 0.03438198338835578 5.9112288790527015e-08 7.228322224717224 -0.19292130552391384 ELES(ph)SEEGGSAEER ddPTM_A459_Selumetinib_30min_R1 2 ELESSEEGGSAEER 14 0 J3QKQ1;J3KRR1;J9JIC5;Q9HAS0 J3QKQ1 C17orf75 Protein Njmu-R1 1 ELES(0.97)S(0.03)EEGGSAEER;ELES(0.988)S(0.012)EEGGSAEER 173.33 0.00010617 6437500.0 1805.79 2034.0700000000002 3881.29 3078.24 2097.76 1853.13 2014.19 2016.41 1370.26 1727.17 True False 1847.8613935443207 1795.9201387865128 3354.232136399884 2540.6831697212447 1908.017978389609 1834.4891947074161 1862.2580266663285 1962.9282565772344 2325.231140169294 1948.869093560483 0.9481711212159323 0.9215191234345349 1.7211172097105176 1.303670512358297 0.9790385535355578 0.9413096040000816 0.9555582942023466 1.007214010968313 1.1931181770250239 1.0 10.928421472018377 -6.267382341748485 24.585483856649347 1.0066398829223822 1.237576446817147 0.18553236841376597 0.21547286676443161 680.1031833500826 2813518.446864894 0.07130209377794135 0.08297807384894357 5.402784661740942e-07 6.267382341748485 0.2309365638947649 ELES(ph)SEEGGSAEER ddPTM_A459_Selumetinib_30min_R2 2 ELESSEEGGSAEER 14 0 J3QKQ1;J3KRR1;J9JIC5;Q9HAS0 J3QKQ1 C17orf75 Protein Njmu-R1 1 ELES(0.941)S(0.059)EEGGSAEER;ELES(0.971)S(0.029)EEGGSAEER 188.63 9.3604e-05 4865300.0 11893.2 9876.0 11340.5 14557.1 14780.1 10743.5 12776.8 13743.2 11030.0 11674.9 True False 11232.223556251816 10633.457443654901 10610.86457660281 12574.397867601829 12923.29170222952 12223.31960521717 13370.94651674889 13783.190436690771 13236.308203949864 11337.815301966879 0.9906867643454428 0.9378753455094839 0.9358826452889951 1.1090670938536482 1.1398396744024921 1.0781018458729588 1.179323014234436 1.2156830985154319 1.1674478593467328 1.0 13.468855051869626 -5.824495822975356 4.722499494467054 1.1390747210555963 0.9526639065765787 0.6480230842534509 0.05797285450953401 0.11682364817844075 5.116819001574383 0.016587637969392787 0.025759106681551753 1.4979736604183674e-06 5.824495822975356 -0.18641081447901753 ELESPLT(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 ELESPLTPGK 10 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 ELES(0.208)PLT(0.792)PGK 150.51 0.0016541 62815000.0 6815.2 9123.8 5370.7 5634.8 5729.3 6842.7 6968.4 6464.1 4165.5 7042.3 True False 6973.980899929256 8055.581254460458 4641.388439143394 4650.787958296063 5211.08582659007 6773.868650674502 6442.767977708974 6292.651069644023 7068.54926391721 7946.247802810954 0.8776445277055465 1.013759129385674 0.5840981245892585 0.5852810123352641 0.6557920110101108 0.852461289752161 0.8107937403399212 0.791902194066742 0.8895455363746317 1.0 12.95605806906621 -8.477697787813502 0.9213459273782184 0.9995962213773771 0.7551019463407446 0.2571672976666318 0.12661464069295547 0.9362337344198414 1.7630993606543757 0.13483988748473905 0.0467586887306712 3.3289112141758688e-09 8.477697787813502 -0.24449427503663257 ELESPLT(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 ELESPLTPGK 10 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 ELES(0.075)PLT(0.925)PGK;ELESPLT(1)PGK 105.25 0.029524 40963000.0 137095.0 122926.0 137755.0 139261.0 144332.0 112717.0 129630.0 137840.0 111159.0 129510.0 True False 129475.80873476804 132354.02893061153 128891.99327630344 120293.41156137543 126199.72381554861 128242.74360694962 135658.05185697184 138241.09157935952 133393.9060419638 125770.70979260895 1.0294591558580584 1.05234381795935 1.0248172526722745 0.9564501286486704 1.0034110805580019 1.019655083591537 1.0786140277069816 1.0991517167018756 1.0606118567822764 1.0 16.940436452639105 -7.202649153928074 5.847748091275533 1.0678041127126858 1.0130621307065506 0.29661262618444506 0.033201897710506134 0.2459660420021875 17.947704601073916 0.013470072383557559 0.010299909421890154 6.271202810495549e-08 7.202649153928074 -0.054741982006135226 ELESQISELQEDLESER ddPTM_A459_Selumetinib_30min_R1 2 ELESQISELQEDLESER 17 0 P35579 P35579 MYH9 Myosin-9 0 ; 434.73 0.0 13056500.0 2623.2 1701.18 1821.61 2075.54 2862.6 1780.22 1898.77 1767.6599999999999 1401.02 2151.61 False True 2684.3154561413357 1502.0050547428737 1574.24536738749 1713.0859017111186 2603.678335433078 1762.3126031104325 1755.5442501915024 1720.7759146311082 2377.428613547783 2427.790101956191 1.105662080909898 0.618671710347873 0.6484272944844129 0.7056153249536689 1.0724478748534172 0.7258916665367611 0.7231038007680208 0.7087828199170075 0.9792562427996434 1.0 11.245427981397018 -8.27903649063853 20.537094507900736 0.9896293122790873 0.780665548148629 0.20309067998516328 0.15868742615996811 144.47449931246578 168595.2515283905 0.1497186808462835 0.03936557973101259 5.259730708037151e-09 8.27903649063853 -0.20896376413045836 ELFDDPS(ph)YVNVQNLDK ddPTM_A459_Selumetinib_30min_R1 1 ELFDDPSYVNVQNLDK 16 0 P29353-3;Q5T188;H0Y539;X6R6D0;P29353-5;P29353-2;P29353-7;P29353;P29353-6 P29353-3 SHC1 SHC-transforming protein 1 1 ELFDDPS(0.726)Y(0.274)VNVQNLDK 210.41 1.6032e-29 0.0 910.3 1007.0 802.17 984.19 825.38 720.17 847.79 974.61 625.15 640.73 True False 931.5082188645393 889.0999718584004 693.2397200044041 812.3196920343947 750.7245247326749 712.9257436620417 783.8405177403553 948.7601768205568 1060.8338908505207 722.9739367387167 1.2884395571249854 1.2297814992737723 0.9588723531743877 1.1235808799674167 1.0383839397020853 0.9861015832437865 1.084189177380589 1.3123020465998338 1.4673196873954626 1.0 9.497799828630841 -7.759796319572043 24.99616817797645 1.2923581872070893 1.0947987227025415 0.19269757833283563 0.14374087034663546 57.2777019597749 871423.3535746535 0.07159735169266475 0.038537368618531694 1.738616033743723e-08 7.759796319572043 -0.19755946450454775 ELFDDPSY(ph)VNVQNLDK ddPTM_A459_Selumetinib_30min_R1 3 ELFDDPSYVNVQNLDK 16 0 P29353-3;Q5T188;H0Y539;X6R6D0;P29353-5;P29353-2;P29353-7;P29353;P29353-6 P29353-3 SHC1 SHC-transforming protein 1 1 ELFDDPS(0.011)Y(0.989)VNVQNLDK;ELFDDPS(0.33)Y(0.67)VNVQNLDK;ELFDDPS(0.047)Y(0.953)VNVQNLDK 234.87 8.845499999999999e-15 27443300.0 8254.199999999999 8517.0 8857.5 9209.2 8103.6 7557.700000000001 7871.7 6932.9 4221.0 5706.4 True False 8446.50680012268 7519.825680554117 7654.700150764819 7600.986098094014 7370.630810806785 7481.676399842559 7277.931331457969 6749.016970767011 7162.728710357594 6438.872025043016 1.3117991423453164 1.1678793508097218 1.188826260406019 1.1804841078578874 1.1447083871429398 1.1619545117131873 1.1303115364230814 1.0481675896830585 1.1124197968990914 1.0 12.652592260826925 -1.522878745875403 0.10648485196666362 0.9267666353944626 1.92241723321342 0.8131119196237255 0.03444647010847565 47.699441670352 0.3578662726258476 0.34955088456613376 6.959261997701258 0.02999999995889434 1.522878745875403 0.9956505978189574 ELFQT(ph)PCTDNPTTDEK ddPTM_A459_Selumetinib_30min_R1 2 ELFQTPCTDNPTTDEK 16 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.789)PCT(0.007)DNPT(0.166)T(0.039)DEK;ELFQT(0.972)PCT(0.022)DNPT(0.006)T(0.001)DEK 240.5 4.1462e-21 19261900.0 4535.9 7449.1 7612.0 8606.3 5544.0 6812.8 7398.700000000001 5547.6 3222.0299999999997 5051.7 True False 4641.577644675011 6576.955909007365 6578.332209723034 7103.371265259357 5042.5461788727 6744.269417527471 6840.6101022724615 5400.45962685558 5467.549582239627 5700.134902724975 0.8142925955061315 1.1538246061269921 1.1540660566784537 1.2461759917056625 0.8846362875485785 1.1831771585446762 1.200078633051698 0.947426634459803 0.9591965235113716 1.0 12.47678034800776 -7.788046273587763 24.954445337955768 0.96498356352467 1.0973321024628926 0.15136681361154658 0.13168510171562717 406.9091642840516 381631.73800194607 0.07137138280040832 0.03430049615220328 1.6291224422311346e-08 7.788046273587763 0.13234853893822263 ELFQT(ph)PCTDNPTTDEK ddPTM_A459_Selumetinib_30min_R2 2 ELFQTPCTDNPTTDEK 16 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.618)PCT(0.363)DNPT(0.014)T(0.005)DEK;ELFQT(0.901)PCT(0.068)DNPT(0.028)T(0.003)DEK 135.69 0.00096298 7509100.0 44957.0 45572.0 48555.0 57167.0 40452.0 43161.0 44017.0 48334.0 34218.0 43705.0 True False 42458.469917130154 49067.225862924366 45431.0241626868 49380.75598142442 35370.05811453161 49106.03597345173 46063.8777180308 48474.64393787557 41062.55613080296 42443.12309077275 1.0003615856996333 1.1560701072346797 1.0703977665716033 1.1634571724567537 0.833351919906694 1.1569845100330876 1.0853083930585026 1.1421083183299978 0.9674725406747947 1.0 15.373243197484404 -8.282526018272117 24.58818160418816 0.98373623682256 1.0763229755427703 0.1311499955731641 0.09499258028839504 1551.5265570041458 1809144.1349118743 0.08803560413950051 0.02282758344824864 5.2176384480349296e-09 8.282526018272117 0.0925867387202104 ELFQT(ph)PDHTEESTTDDK ddPTM_A459_Selumetinib_30min_R2 4 ELFQTPDHTEESTTDDK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.999)PDHTEESTTDDK;ELFQT(1)PDHTEESTTDDK;ELFQT(1)PDHTEESTTDDK;ELFQT(1)PDHTEESTTDDK 129.51 0.0012647 24887200.0 126730.0 119198.0 127434.0 109536.0 117995.0 120478.0 121478.0 122262.0 104734.0 139501.0 True False 119686.85394038534 128340.10331802108 119235.03517964855 94617.00783986071 103171.41321131616 137072.7509096062 127126.9677040903 122617.76217843637 125683.72651246442 135473.24366287375 0.8834722687989005 0.9473465006669247 0.8801371544359408 0.6984184129769262 0.761563024711057 1.011806812943173 0.9383917020577641 0.9051068599462463 0.9277383719048565 1.0 17.047648417923277 -6.765001692375427 24.99998602416081 0.9495393586511868 0.835484120727239 0.4263786872179748 0.07075212418342729 113.11059480663947 793793.710212643 0.027726465606967697 0.025413436911950346 1.7179016927592094e-07 6.765001692375427 -0.11405523792394778 ELFQT(ph)PDHTEESTTDDKTTK ddPTM_A459_Selumetinib_30min_R1 1 ELFQTPDHTEESTTDDKTTK 20 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.963)PDHT(0.037)EESTTDDKTTK 96.504 0.0013732000000000002 13582000.0 1263.6 2407.9 2397.7 2990.0 2015.4 1977.6 2585.1 1706.4 942.19 1869.0 True False 1293.03942146241 2125.9819485976595 2072.105509623347 2467.8526292513 1833.1074258477695 1957.7071395171347 2390.1038257240502 1661.1407288316323 1598.8276151650832 2108.9043556016745 0.6131332689544867 1.0080978508819631 0.9825507278788712 1.1702060468964308 0.8692226468112065 0.9283053232438305 1.1333391290958517 0.7876795002197744 0.7581318758806085 1.0 11.042277951236027 -9.869750051871229 9.940107601209583 0.9999457500646399 0.9303353039593233 0.017171838008819607 0.1618279027728433 0.0 0.0 0.15733158946842468 0.03815851538968413 1.3497394703825704e-10 9.869750051871229 -0.06961044610531664 ELFQT(ph)PGHTEEAVAAGK ddPTM_A459_Selumetinib_30min_R2 3 ELFQTPGHTEEAVAAGK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(1)PGHTEEAVAAGK;ELFQT(1)PGHTEEAVAAGK;ELFQT(0.983)PGHT(0.017)EEAVAAGK 126.9 0.0015369 20313900.0 181318.0 199182.0 199838.0 197604.0 203093.0 169509.0 160067.0 186573.0 137627.0 207440.0 True False 171241.07143346325 214458.61892892595 186980.6406471628 170689.99431408633 177578.6416655434 192857.32610050327 167510.43266674323 187115.89654117692 165156.24561967418 201450.66820615256 0.850039729122295 1.0645713952631908 0.9281708634285492 0.847304185357243 0.8814993926146725 0.957342697434712 0.8315208589694182 0.9288422729364874 0.8198346875209327 1.0 17.62006706530979 -5.521947044437067 24.9377015775279 0.8912966308059121 0.967071952501133 0.10489557083243706 0.07176498913235752 52.38112281314797 1402020.416499954 0.017938589491500612 0.03159138345845422 3.0064428699578893e-06 5.521947044437067 0.07577532169522083 ELFQT(ph)PGHTEELVAAGK ddPTM_A459_Selumetinib_30min_R1 2 ELFQTPGHTEELVAAGK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(1)PGHTEELVAAGK;ELFQT(1)PGHTEELVAAGK 153.06 0.00019423 19028100.0 6713.2 14430.9 10762.8 12906.8 9747.0 9820.4 13381.7 9890.599999999999 5450.0 8244.8 True False 6869.604498386709 12741.323519256595 9301.270875828564 10652.86967064237 8865.385570972623 9721.615692209778 12372.307595331526 9628.26915880341 9248.251947749075 9303.100391152851 0.7384209789802579 1.3695782033453554 0.9998033434825634 1.1450881128589276 0.9529495757568638 1.044986647833547 1.3299122953781577 1.0349527312378346 0.9941042834004096 1.0 13.183495879756535 ELFQT(ph)PGHTEELVAAGK ddPTM_A459_Selumetinib_30min_R2 1 ELFQTPGHTEELVAAGK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.999)PGHT(0.001)EELVAAGK 74.89 0.030777 9125300.0 81971.0 87597.0 95629.0 98381.0 90590.0 80326.0 77767.0 93765.0 68985.0 99906.0 True False 77415.37997591206 94315.40823125132 89476.33425298256 84981.33808330898 79209.27431512452 91390.1773731722 81383.31959238702 94037.84062636866 82783.92760194754 97021.45419303814 0.7979202189845869 0.9721087878521925 0.9222324587606832 0.8759025391871202 0.8164098855653749 0.9419584372683005 0.8388177673616725 0.9692478989159125 0.853253832263089 1.0 16.56601618288513 -14.522878745169702 0.3969201677427224 2.7191408224371525 0.8890703615853296 0.24315806613614244 0.059101239031329224 1060.3461617439555 7.503270280096264 1578.0374389230583 0.03570913815135162 3.000000000764241e-15 14.522878745169702 -1.830070460851823 ELFQT(ph)PGPSEESMTDEK ddPTM_A459_Selumetinib_30min_R1 4 ELFQTPGPSEESMTDEK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.954)PGPS(0.046)EESMTDEK;ELFQT(1)PGPSEESMTDEK;ELFQT(1)PGPSEESMTDEK;ELFQT(0.999)PGPS(0.001)EESMTDEK 190.8 1.7901e-07 18078900.0 4973.87 8167.1 6430.76 7188.700000000001 5686.65 5901.5 7801.200000000001 5756.1900000000005 3084.17 5369.48 True False 5089.751493533743 7210.892135218218 5557.498113636164 5933.3284936116515 5172.2935115596 5842.136268133273 7212.749203217851 5603.517142459772 5233.611231135645 6058.705061164303 0.8400724976956783 1.1901705170366057 0.9172749056987729 0.9793063754899868 0.8536962039485116 0.9642549371780426 1.190477029398717 0.924870427903441 0.8638168021550632 1.0 12.564793761286138 ELFQT(ph)PGPSEESMTDEK ddPTM_A459_Selumetinib_30min_R2 2 ELFQTPGPSEESMTDEK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.999)PGPS(0.001)EESMTDEK;ELFQT(0.951)PGPS(0.047)EES(0.001)MTDEK 164.82 9.2584e-06 6375000.0 50769.0 52033.0 46708.0 50004.0 46680.0 45045.0 40665.0 44126.0 34721.0 51428.0 True False 47947.462224409595 56023.76378753494 43702.85813182527 43193.36893828868 40815.64107550519 51249.539872202506 42556.00307616881 44254.39935454746 41666.17018579722 49943.14001400892 0.9600410028476476 1.1217509305946807 0.8750522718348653 0.8648508869521031 0.8172421890985732 1.0261577437427272 0.8520890569602144 0.8860956548213472 0.8342721377572571 1.0 15.607998908469336 -5.277802564018352 24.90970334359369 0.8897755416288045 1.0408959676214902 0.38534329991377536 0.07378220241041039 629.5079422503941 958300.717102206 0.018441119067313442 0.03856116992938587 5.274696015403052e-06 5.277802564018352 0.15112042599268571 ELFQT(ph)PGTDKPTTDEK ddPTM_A459_Selumetinib_30min_R1 1 ELFQTPGTDKPTTDEK 16 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.997)PGT(0.003)DKPTTDEK 85.734 0.022248 23802000.0 1994.0 3975.8 3079.9 3675.6 2473.0 2842.1 2949.8 2436.9 1444.8 2749.0 True False 2040.4563203514122 3510.311487700725 2661.6664966797116 3033.7254595572203 2249.317586643611 2813.5110544203317 2727.294211102394 2372.265495833221 2451.7200759830953 3101.860927527558 0.6578168293243972 1.1316791982994339 0.8580869867693527 0.9780340029542693 0.7251510106987629 0.9070397158853072 0.8792445163801316 0.7647878326137962 0.7904029655956628 1.0 11.598918289003823 -6.234132403435489 24.95401142262844 0.8375474693248388 0.9190440758320658 0.045546739110515655 0.13181697024956515 1933.9362413377717 1767295.0250409734 0.03659867884636649 0.04723761598257024 5.832672563732787e-07 6.234132403435489 0.08149660650722701 ELFQT(ph)PICTDKPTTHEK ddPTM_A459_Selumetinib_30min_R2 1 ELFQTPICTDKPTTHEK 17 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(1)PICTDKPTTHEK 66.64399999999999 0.023091 3771900.0 46402.0 45955.0 48091.0 42600.0 42072.0 46628.0 38551.0 46058.0 33911.0 53651.0 True False 43823.16260192348 49479.600731385275 44996.87741752181 36797.80651090106 36786.53923154788 53050.583753159255 40343.6978873573 46192.02115468764 40694.14755250629 52101.956227961295 0.8411039771747596 0.9496687708787277 0.8636312467932551 0.7062653530685085 0.7060490986287735 1.0182071383471176 0.7743221331429827 0.8865698046457995 0.7810483616864115 1.0 15.66904992071726 -10.927979671919633 3.5589765858978812 1.0012364241277698 0.8378032705445422 0.21111566144131677 0.09488306468650436 141576483.08118555 138803488.2138602 1669236.4335429415 0.024131334900928243 1.180375884371862e-11 10.927979671919633 -0.16343315358322763 ELFQT(ph)PVCTDKPTTHEK ddPTM_A459_Selumetinib_30min_R2 2 ELFQTPVCTDKPTTHEK 17 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.992)PVCT(0.008)DKPTTHEK;ELFQT(0.992)PVCT(0.008)DKPTTHEK 95.236 0.0036758 24246000.0 221170.0 256590.0 270290.0 250160.0 235400.0 243350.0 227250.0 229200.0 196644.0 266030.0 True False 208878.25681365925 276269.6279331114 252899.83566950035 216087.77644992984 205826.94749729926 276869.25358864444 237817.57528733206 229866.9340538976 235978.2946924313 258349.02267105097 0.8085118908292463 1.069365872093421 0.9789076538969961 0.8364180139557513 0.7967010881994832 1.0716868627026888 0.9205282560334627 0.889753449335015 0.9134088925619674 1.0 17.978961900524745 -6.752804738275608 24.99994608506006 0.9497758883243415 0.908578105624237 0.09259839723911212 0.09038871065233453 755.878257520569 2188496.3763104803 0.031732912568492345 0.03126050292872383 1.7668320217117396e-07 6.752804738275608 -0.041197782700104435 ELFQTPCT(ph)DNPTTDEK ddPTM_A459_Selumetinib_30min_R2 1 ELFQTPCTDNPTTDEK 16 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.198)PCT(0.802)DNPT(0.001)TDEK 128.82 0.002156 4237500.0 19004.0 22830.0 20636.0 20494.0 16977.0 21042.0 24461.0 21230.0 15429.0 20756.0 True False 17947.833759039575 24580.987589979875 19308.302226777978 17702.681845878084 14844.197483694334 23940.34449974216 25598.484968551962 21291.775785184294 18515.231122279478 20156.72034943551 0.8904143852718682 1.2194934078483788 0.9579089203030348 0.8782520935442679 0.7364391243394934 1.1877103062757237 1.269972720004961 1.0563115137815846 0.918563675106898 1.0 14.298973300107882 -6.80416800091583 24.99999950351711 1.1014973847978187 0.9501751711085304 0.20620395163955907 0.14444537725207898 250.30401857173698 146448.12904230275 0.05470395563781674 0.04824470552835351 1.569755448314005e-07 6.80416800091583 -0.15132221368928822 ELFQTPDHT(ph)EESTTDDK ddPTM_A459_Selumetinib_30min_R1 1 ELFQTPDHTEESTTDDK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.137)PDHT(0.732)EES(0.005)T(0.045)T(0.081)DDK 141.13 0.00054627 0.0 349.08 608.86 354.44 449.39 344.07 383.13 394.32 351.56 169.99 479.6 True False 357.2128848085612 537.5743881486652 306.3089947995577 370.9124725950644 312.94892925049226 379.2760600542069 364.5761249311468 342.2354867721806 288.460614421627 541.1613316996057 0.6600857524070977 0.9933717667157128 0.5660215851667453 0.685400916266787 0.5782913724963034 0.7008558036898689 0.6736921202151229 0.6324093513801772 0.5330399596653908 1.0 9.07991494601773 -10.62851409610348 4.64969327380079 1.000021186276887 0.6735161411713285 0.40331929890179563 0.12059141529287427 64756307928.42314 12456025356.41302 16294461.641119706 0.029444552955573276 2.3522631436212656e-11 10.62851409610348 -0.32650504510555856 ELFQTPDHT(ph)EESTTDDKTTK ddPTM_A459_Selumetinib_30min_R1 1 ELFQTPDHTEESTTDDKTTK 20 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.017)PDHT(0.97)EES(0.005)T(0.005)T(0.004)DDKTTK 72.77199999999998 0.011344 18203000.0 1330.8 2521.3 2241.4 3068.0 2035.7 2184.5 2474.7 1925.5 1070.3 1589.5 True False 1361.8050507139717 2226.1050238794296 1937.030191128903 2532.2313934926397 1851.5712944320262 2162.525913367304 2288.0313866075985 1874.4294850945307 1816.2209283808886 1793.5278080411247 0.7592885064889645 1.2411879057012012 1.0800112395494499 1.4118718327865352 1.0323627468337366 1.2057387143214666 1.2757155904410349 1.0451075677169266 1.0126527842155675 1.0 10.808584398628845 -10.18828035345591 8.643134650087546 1.000003820204876 1.1318766547504413 0.03625930572095404 0.17019097089588567 0.0 0.0 0.15865347999942617 0.03847912093585018 6.482158506954616e-11 10.18828035345591 0.1318728345455653 ELFQTPDHT(ph)EESTTDDKTTK ddPTM_A459_Selumetinib_30min_R2 1 ELFQTPDHTEESTTDDKTTK 20 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ELFQT(0.013)PDHT(0.724)EES(0.18)T(0.07)T(0.008)DDKT(0.001)T(0.004)K 61.957 0.03428 9163400.0 17368.0 19867.0 21902.0 19210.0 15280.0 14520.0 13212.0 14001.0 10722.0 21515.0 True False 16402.756089612674 21390.735017526527 20492.84916509455 16593.56486090162 13360.389795066827 16519.998200563437 13826.38417908134 14041.740592009677 12866.699597710836 20893.80604731667 0.785053525071811 1.0237835542784546 0.9808097729387312 0.7941858378183176 0.6394426063308204 0.7906648584346868 0.6617455980863296 0.6720527873289518 0.6158140632000013 1.0 14.350787699404805 -5.930599182708659 4.462518389313265 0.7131180721057689 0.9374675849536237 0.35588364024425534 0.1185442083578898 0.19475092636335484 7.571663712326631 0.03230734851021036 0.04871470439739047 1.1732777026886747e-06 5.930599182708659 0.22434951284785476 ELGEYGFHEYT(ph)EVK ddPTM_A459_Selumetinib_30min_R1 2 ELGEYGFHEYTEVK 14 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 ELGEYGFHEYT(1)EVK;ELGEY(0.175)GFHEY(0.002)T(0.823)EVK 109.04 0.0063641 10098500.0 7887.3 9154.2 8277.4 8978.1 6838.5 7033.3 6636.4 8065.4 5050.9 6764.7 True False 8071.0587439858045 8082.422008327876 7153.3745445036075 7410.243374809734 6219.958882435233 6962.551387725456 6135.811005003705 7851.479391888568 8571.008396859781 7633.0151387579745 1.0573880173515688 1.058876716657872 0.9371623682731994 0.97081470953502 0.8148757429881541 0.9121626593365286 0.8038515440442463 1.028620964213906 1.1228863353537688 1.0 12.89803733732902 -11.0564366166953 12.133182443562514 1.0000000872211643 0.9601847611268157 0.004903898387281336 0.0994222436923332 2.5181884946811715e-07 9.709384496931403e-09 0.10334368194685899 0.02506446977832667 8.781392381732818e-12 11.0564366166953 -0.03981532609434857 ELGEYGFHEYTEVK ddPTM_A459_Selumetinib_30min_R1 4 ELGEYGFHEYTEVK 14 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ;;; 204.35 3.4876e-05 150795000.0 20218.72 31638.8 23785.23 29215.4 22048.85 23488.42 24046.96 17569.7 11313.529999999999 17544.079999999998 False True 20689.776837219422 27934.514587520924 20555.326408916262 24113.47883097942 20054.535410540626 23252.14782057899 22233.078446881438 17103.69448157123 19198.234102461945 19796.03356181072 1.0451475934619983 1.4111167522675077 1.0383558072244494 1.21809648158496 1.0130582648247572 1.1745861991987925 1.1231077365807316 0.8639960337593394 0.9698020587062445 1.0 14.272923772786221 -7.672249471794682 6.2175583228240034 0.9387428474659609 1.1529102399228366 0.40356448250247234 0.11239898867999971 0.1914196920374491 10.769520052288135 0.051752924571755406 0.029329352759269168 2.1269169300385135e-08 7.672249471794682 0.21416739245687566 ELGEYGFHEYTEVK ddPTM_A459_Selumetinib_30min_R2 3 ELGEYGFHEYTEVK 14 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ;; 166.03 0.00033784 24574200.0 180588.0 207704.0 211161.0 192162.0 211309.0 152719.0 138624.0 142162.0 109458.0 207560.0 False True 170551.6419110417 223634.2289263763 197575.1311547132 165989.20410206058 184762.4742935718 173754.65600494828 145070.290678245 142575.66788381405 131352.65851205293 201567.20349435502 0.8461279362632923 1.1094772614268038 0.9801948319447036 0.8234931140804818 0.9166296455501808 0.8620184880910666 0.719711779313879 0.7073356449468573 0.6516568977240959 1.0 17.620901394995244 -6.570457895085175 1.0180984909825055 0.7493556827711194 0.9779234707056922 0.3043964175569547 0.11417000937101544 0.5438340804110364 1.2139688417976038 0.058045080874406636 0.06430646845953535 2.6886985001497897e-07 6.570457895085175 0.22856778793457277 ELGITALHIK ddPTM_A459_Selumetinib_30min_R1 2 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 ; 128.81 0.0042918 16215700.0 11302.1 12368.3 10912.5 11700.4 11234.1 10125.599999999999 11636.5 11838.3 6745.4 10097.3 False True 11565.416939941677 10920.213686133327 9430.642438071805 9657.144783709677 10217.977638541452 10023.745657309211 10758.749436400105 11524.309827782188 11446.451135476442 11393.386811030923 1.0150991212502498 0.9584694935100881 0.8277295061150022 0.8476096654911918 0.8968340852474651 0.8797863026650123 0.9442977417376569 1.0114911412139986 1.0046574671189206 1.0 13.475909047506597 -7.584180176495543 3.3466644105442604 1.006105773393036 0.9005961647239686 0.44586043057954483 0.05021344557077117 0.2441135546752016 5.558336033506438 0.028789285094303656 0.015708206507991533 2.6050725548645843e-08 7.584180176495543 -0.10550960866906745 ELGLGCS(ph)PPAETLADAK ddPTM_A459_Selumetinib_30min_R2 1 ELGLGCSPPAETLADAK 17 0 O60303 O60303 KIAA0556 Uncharacterized protein KIAA0556 1 ELGLGCS(0.813)PPAET(0.187)LADAK 109.1 0.0033125 0.0 11537.0 6093.2 11198.0 10161.0 12064.0 9568.4 12109.0 11650.0 12908.0 7131.6 True False 10895.819726270232 6560.528847274 10477.532871460538 8777.054271297318 10548.412466471602 10886.360246712899 12672.092493528293 11683.899571238677 15489.960679654123 6925.692177877928 1.5732463191294728 0.9472741032628719 1.5128499220522555 1.2673179872667484 1.5230842196777645 1.5718804658234957 1.8297221661115026 1.6870370890233084 2.236593871314728 1.0 12.75774255101357 -6.651525897409059 1.5315078717038975 1.7427147088932846 1.3038146689431047 0.18431424972829413 0.3262529605999821 0.5308336748877815 2.5792545038322823 0.13035786070558464 0.12945538770472842 2.2308691745824687e-07 6.651525897409059 -0.4389000399501799 ELGPLPDDDDMAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ELGPLPDDDDMASPK 15 0 Q86U86-8;Q86U86;E7EVG2;Q86U86-6;Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;H0Y5B5 Q86U86-8 PBRM1 Protein polybromo-1 1 ELGPLPDDDDMAS(1)PK 205.78 2.2089e-06 2024700.0 9774.9 8865.5 10981.0 11644.0 10395.0 7789.0 9592.6 7188.2 5162.6 9415.0 True False 9231.650190025039 9545.455342924513 10274.49441520881 10058.06711297962 9089.087167520916 8861.86404849784 10038.674907376293 7209.11647192943 6195.264255096248 9143.164486892238 1.0096777984536596 1.0439990833161763 1.123735051462594 1.100064110997784 0.9940854920144062 0.9692337987796595 1.0979431598072933 0.7884706090833776 0.677584250395786 1.0 13.158477859070723 -7.76689713757041 24.998013854618208 0.7997704841727276 1.0479743533782615 0.5805255408141898 0.08757024095809561 86.36855464279161 395582.1147163567 0.04515233648303661 0.02267145453236152 1.7104203793252695e-08 7.76689713757041 0.24820386920553394 ELGTGEQPLS(ph)PTTATSPYGGGHALAGQTSPK ddPTM_A459_Selumetinib_30min_R1 1 ELGTGEQPLSPTTATSPYGGGHALAGQTSPK 31 0 H7BY14;A0A087WYU3;Q96NU1-6;Q96NU1;H7C3J6;A0A087X1J5;Q96NU1-1;Q96NU1-2;A0A087WXB3;A0A087X223;A0A087WYW1;Q96NU1-4;Q96NU1-5 H7BY14;A0A087WXB3 SAMD11 Sterile alpha motif domain-containing protein 11 1 ELGTGEQPLS(0.8)PT(0.184)T(0.016)AT(0.001)SPYGGGHALAGQTSPK 138.76 1.5341e-18 12070000.0 2268.3 3008.7 2665.1 2694.2 3147.3 2278.1 3460.9 2817.3 1088.6 2192.0 True False 2321.146976656525 2656.4400052933174 2303.1940583464084 2223.708546397612 2862.627270700946 2255.1843823493036 3199.841526613423 2742.5760521198786 1847.274691801771 2473.3645518881067 0.938457282766755 1.0740187908270358 0.9311987820752933 0.8990621882650038 1.1573818620937564 0.911788106863483 1.2937201368762001 1.1088442462015 0.7468671330280068 1.0 11.272259180451396 -6.242010211056942 24.806328513872558 1.0485078648877229 0.9666734926740815 0.05835025859015741 0.14345885989810425 2302.826046741316 2940147.9886468784 0.0424880264002645 0.05475716233573694 5.727825636626779e-07 6.242010211056942 -0.08183437221364132 ELGTGEQPLS(ph)PTTATSPYGGGHALAGQTSPK ddPTM_A459_Selumetinib_30min_R2 2 ELGTGEQPLSPTTATSPYGGGHALAGQTSPK 31 0 H7BY14;A0A087WYU3;Q96NU1-6;Q96NU1;H7C3J6;A0A087X1J5;Q96NU1-1;Q96NU1-2;A0A087WXB3;A0A087X223;A0A087WYW1;Q96NU1-4;Q96NU1-5 H7BY14;A0A087WXB3 SAMD11 Sterile alpha motif domain-containing protein 11 1 ELGT(0.002)GEQPLS(0.543)PT(0.221)T(0.221)AT(0.01)S(0.002)PYGGGHALAGQTSPK;ELGTGEQPLS(0.907)PT(0.083)T(0.008)AT(0.001)SPYGGGHALAGQTSPK 137.53 1.8201e-18 34278000.0 136116.0 108954.0 156423.0 174116.0 188798.0 111397.0 121309.0 144548.0 139779.0 184984.0 True False 128551.21763552044 117310.42145767288 146358.9144804849 150401.10043314705 165079.50736446498 126740.92558871661 126950.10886922319 144968.61074879038 167738.70575157864 179643.0312738473 0.7155925655671962 0.6530196057471621 0.8147208018182226 0.8372220139387209 0.9189307605972106 0.7055154029076314 0.7066798415113628 0.8069815440143663 0.9337334410477536 1.0 17.454773445726445 -14.522878739232409 0.09837976264112594 1.7144150064969934 0.6307793414408112 0.4739982094447206 0.07917971341552119 196.72539640492747 1.3165460220055656 28.621898659908595 1.571299497925507 3.0000000417776107e-15 14.522878739232409 -1.0836356650561823 ELGTGEQPLSPTTATSPYGGGHALAGQTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ELGTGEQPLSPTTATSPYGGGHALAGQTSPK 31 0 H7BY14;A0A087WYU3;Q96NU1-6;Q96NU1;H7C3J6;A0A087X1J5;Q96NU1-1;Q96NU1-2;A0A087WXB3;A0A087X223;A0A087WYW1;Q96NU1-4;Q96NU1-5 H7BY14;A0A087WXB3 SAMD11 Sterile alpha motif domain-containing protein 11 1 ELGTGEQPLSPT(0.001)T(0.001)AT(0.001)S(0.001)PY(0.005)GGGHALAGQT(0.047)S(0.944)PK 58.059 0.001708 5483400.0 7828.8 5086.4 6109.6 6193.7 6482.2 6697.4 8106.1 7381.2 6040.5 6075.7 True False 7393.706637169488 5476.510524646238 5716.514987629516 5350.107375271551 5667.848084396739 7619.9060570560305 8483.049711932425 7402.678069976561 7248.768785671729 5900.2787544356015 1.2531114113229287 0.9281782696333134 0.9688550703357975 0.9067550192013466 0.9606068323697198 1.291448484756365 1.437737107853624 1.2546319213158386 1.2285468343715769 1.0 12.526567399838582 -6.762756226600556 24.999417845213063 1.2705914150324193 0.9920170971182658 0.42797990982651046 0.13588717389156613 29.6294494357379 562485.22753007 0.04588314496747257 0.042696590468510945 1.7268068922528156e-07 6.762756226600556 -0.27857431791415355 ELHIQGNR ddPTM_A459_Selumetinib_30min_R2 1 ELHIQGNR 8 0 Q15404-2;Q15404 Q15404-2 RSU1 Ras suppressor protein 1 0 90.37 0.039849 2016200.0 13862.0 12975.0 16228.0 16014.0 17190.0 13616.0 14200.0 11866.0 12140.0 13786.0 False True 13091.60553398266 13970.14077879934 15183.908147710465 13832.865574309151 15030.438519450177 15491.480406258397 14860.328136766195 11900.528095477954 14568.339219941206 13387.96235967036 0.9778639334555914 1.0434852148137734 1.1341463129184002 1.03323158541131 1.1226830577838776 1.1571201046191042 1.109976838710808 0.8888976362322973 1.0881670286007519 1.0 13.708648779547207 -7.720237795826663 24.99997594632787 0.9913985154388494 1.0856226315073942 0.2725907615461741 0.06746108198817088 180.82482136572733 109719.37375815357 0.031750232530424916 0.018330779570750383 1.90441767781684e-08 7.720237795826663 0.09422411606854486 ELHPQLLS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 4 ELHPQLLSPTK 11 0 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 ELHPQLLS(1)PTK;ELHPQLLS(0.98)PT(0.02)K;ELHPQLLS(0.985)PT(0.015)K;ELHPQLLS(0.833)PT(0.167)K 166.62 0.00035152 101262900.0 23639.2 25511.4 25591.6 25247.0 19744.3 23516.1 23033.0 20143.0 11995.5 18084.5 True False 24189.947366123924 22524.513428071907 22116.401284596435 20838.085394885493 17958.43155113929 23279.54938491044 21295.602266025322 19608.742206314793 20355.487383343876 20405.82173294729 1.1854434328937988 1.103827805753285 1.0838280160454032 1.0211833499084366 0.880064120237979 1.140828812952101 1.043604249058071 0.9609386214844007 0.9975333338562816 1.0 14.316693187973334 -5.207867855243662 1.3665719502172975 1.0071988256988118 1.1889190260539702 0.4552801080824219 0.0630098941915146 0.6465114696997887 1.782661548974558 0.0199811242212653 0.1309176667677106 6.196295839064771e-06 5.207867855243662 0.18172020035515835 ELHPQLLSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 2 ELHPQLLSPTK 11 0 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 ELHPQLLS(0.466)PT(0.534)K;ELHPQLLS(0.2)PT(0.8)K 112.62 0.010256 104752000.0 571200.0 511220.0 584630.0 536330.0 518680.0 478200.0 516040.0 535220.0 415520.0 512220.0 True False 539454.9906947702 550428.9301686166 547015.5422970164 463280.9287791445 453518.7813419676 544067.7093326056 540036.882513861 536777.4015895589 498635.61059884477 497430.87769261096 1.0844823168137308 1.1065435517832005 1.0996815172279 0.9313473480539148 0.9117222144424677 1.0937554014666817 1.0856521111413164 1.0790994802724376 1.0024219101794045 1.0 18.924136539111373 -5.634488279971095 19.226585684908464 1.0197212691188187 1.097971166668971 0.29251188872222267 0.05811730545997934 2.834038472493008 471.92634290882364 0.01776568536675406 0.030771092245914164 2.320126796510706e-06 5.634488279971095 0.07824989755015244 ELHYLPFPS(ph)P ddPTM_A459_Selumetinib_30min_R2 2 ELHYLPFPSP 10 0 Q8N565 Q8N565 MREG Melanoregulin 1 ELHYLPFPS(1)P;ELHYLPFPS(1)P 115.7 0.0065656 1837550.0 28566.5 14745.4 21140.2 32450.2 20763.6 17667.6 33912.1 28319.3 25295.4 19214.1 True False 26978.88829076005 15876.324766066122 19780.062547709433 28030.426780282673 18155.090939060836 20101.151529495495 35489.079845551336 28401.704474487517 30355.186812528893 18659.33900877282 1.4458651658601485 0.8508514025390587 1.0600623386717878 1.5022197070916592 0.9729761022362632 1.077270289158946 1.9019473213314737 1.522117394465809 1.6268093311481822 1.0 14.187610260398515 -7.2323462829355005 24.68108414201171 1.5562283789305504 1.1415383443968983 0.280669895343045 0.2795431369311866 674.6538497370318 572342.211819135 0.1025397566607727 0.07941276304862432 5.856709959091672e-08 7.2323462829355005 -0.41469003453365216 ELILFSNSDNER ddPTM_A459_Selumetinib_30min_R2 2 ELILFSNSDNER 12 0 Q02880;Q02880-2;E9PCY5;P11388;P11388-2;P11388-3;P11388-4 Q02880;P11388 TOP2B;TOP2A DNA topoisomerase 2-beta;DNA topoisomerase 2;DNA topoisomerase 2-alpha 0 ; 151.13 0.0073529 3978100.0 18207.6 18247.9 20041.8 17311.199999999997 21796.0 17022.6 14300.1 18492.7 14688.0 16459.4 False True 17195.694482797768 19647.455253753582 18752.332407861937 14953.384696514333 19057.79162128774 19367.30863422255 14965.082985110586 18546.510695368714 17626.010417009576 15984.174355342982 1.0757949769892128 1.2291817404498022 1.17318117226328 0.9355118609248597 1.1922912749583057 1.2116552412198067 0.9362437278537475 1.160304578958076 1.102716350883509 1.0 13.964356604792966 -8.317856442011871 0.014219531086418644 1.0718795989248818e-06 2.1620344509030343 0.10370475401391677 0.09978980922125952 1453.834903227575 16.793729787934097 1290.411440355495 1259.041165683572 4.809983183248303e-09 8.317856442011871 2.1620333790234354 ELILGSETPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 ELILGSETPSSPR 13 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 ELILGS(0.004)ET(0.066)PS(0.742)S(0.188)PR 95.428 0.015005 5309800.0 39601.0 34020.0 40172.0 46655.0 46363.0 38231.0 30084.0 35866.0 33546.0 39566.0 True False 37400.13495536339 36629.22460845886 37587.37725596653 40300.50851563591 40538.46544952115 43496.97322353589 31482.96561031508 35970.36412206407 40256.137353554186 38423.62677518621 0.9733629564483542 0.9532995108133269 0.9782360597006494 1.0488470740003593 1.0550400587302367 1.1320371571906382 0.819364756859616 0.9361522360323767 1.0476922855067758 1.0 15.229706079803021 -10.245732274500181 21.54448708778329 0.9999999999860575 0.9927962687992401 0.00040183452397812847 0.08053214438354707 0.0 0.0 0.08196579502326982 0.019879625327568703 5.6789458224116595e-11 10.245732274500181 -0.007203731186817386 ELILGSETPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ELILGSETPSSPR 13 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 ELILGSET(0.006)PS(0.206)S(0.788)PR;ELILGSETPS(0.054)S(0.945)PR 201.72 8.953e-05 45385000.0 7143.299999999999 8498.7 9045.5 9796.9 8291.2 7880.099999999999 7932.9 7169.0 4585.5 6073.6 True False 7309.724991557795 7503.668253061564 7817.1707833749 8086.055325589325 7541.262423930252 7800.833348558334 7334.514966185573 6978.854831806123 7781.258588330898 6853.205721873904 1.0666139742787502 1.094913615260597 1.1406589996888952 1.179893856065117 1.1003992481737743 1.1382750883516914 1.0702312558304556 1.0183343554872686 1.1354187958337303 1.0 12.742563279624616 -7.378946500372703 4.99774113679028 1.0554406748461809 1.1215705299102217 0.3439691689972125 0.04372748858975675 0.27584506321949737 10.187467678679859 0.01883194361616049 0.01244823815789606 4.1788184127208615e-08 7.378946500372703 0.06612985506404079 ELILGSETPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 ELILGSETPSSPR 13 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 ELILGSET(0.001)PS(0.089)S(0.911)PR;ELILGSETPS(0.053)S(0.947)PR;ELILGS(0.004)ET(0.001)PS(0.214)S(0.782)PR 204.17 4.3512e-05 24801100.0 137910.0 126690.0 140607.0 158321.0 168781.0 101886.0 122386.0 126535.0 112864.0 135423.0 True False 130245.51429747156 136406.71562744453 131560.49870132605 136757.4066810412 147577.2218587155 115919.87167097842 128077.19150325833 126903.195901003 135439.95368364415 131512.98611878967 0.9903623827674838 1.037210998343803 1.000361276737291 1.0398775871267534 1.1221494258020703 0.8814328918535337 0.9738748642477941 0.9649480225958609 1.0298599224361573 1.0 17.00484573847274 -6.761207110592875 24.99999999979509 0.9680731381241957 1.0359630355233989 0.3318055041149407 0.04814436116704569 7.789459717137222 838491.1723169653 0.01656420682369318 0.015582723780523593 1.7329773614981018e-07 6.761207110592875 0.06788989739920315 ELIPQES(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ELIPQESPR 9 0 Q96DF8 Q96DF8 DGCR14 Protein DGCR14 1 ELIPQES(1)PR;ELIPQES(1)PR 145.23 0.0018742 22744000.0 6527.9 7120.0 6811.2 6867.8 6323.2 6449.1 7229.7 6707.700000000001 4098.200000000001 5875.1 True False 6679.987368917744 6286.387090001802 5886.276451243499 5668.467654572605 5751.267676451635 6384.227909314295 6684.357908335136 6529.790006319705 6954.346079314735 6629.226313320167 1.0076571613636998 0.9482836748793 0.8879281190651386 0.8550722794276762 0.8675624280461748 0.9630426851601681 1.0083164448472959 0.9850003149235284 1.0490433952060594 1.0 12.694624790132938 -7.014721306221698 4.10916695255109 1.0078626016766272 0.9104980527916561 0.5273124412263346 0.04325164092286922 0.1921373931704021 7.510210285966751 0.01833723011889445 0.014897139116792617 9.666710083826083e-08 7.014721306221698 -0.09736454888497115 ELIS(ph)NASDALDK ddPTM_A459_Selumetinib_30min_R2 2 ELISNASDALDK 12 0 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 ELIS(0.854)NAS(0.146)DALDK;ELIS(0.989)NAS(0.011)DALDK 121.18 0.0038493 2106700.0 36429.0 29324.0 36460.0 32332.0 34288.0 32027.0 26697.0 25437.0 23419.6 29062.0 True False 34404.4220168413 31573.056508478756 34114.203294646475 27928.325824189043 29980.4349013908 36438.4285378406 27938.463399101925 25511.01745867795 28104.174398297753 28222.904547855785 1.2190248511985684 1.1187033019561232 1.2087417592615668 0.9895624235568227 1.062273191993931 1.2910942059862858 0.989921620282861 0.9039118357014084 0.9957931279058572 1.0 14.784578849453258 -7.493505743567672 23.368297236936478 0.959294817772589 1.1386873762520722 0.5167000993797788 0.08314001666647465 251.18420863715176 199835.5527175067 0.035245810903340856 0.023702671848978847 3.209920352562219e-08 7.493505743567672 0.1793925584794832 ELISNASDALDK ddPTM_A459_Selumetinib_30min_R1 2 ELISNASDALDK 12 0 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 0 ; 257.54 7.830099999999998e-24 26496000.0 4743.7 5955.2 4899.3 4999.0 5144.1 4738.1 4922.1 4593.2 3963.3 4670.0 False True 4854.218980366598 5257.96241550263 4234.00196992854 4126.018492851925 4678.81706326462 4690.439015850593 4550.822034194556 4471.373415183693 6725.430632020905 5269.439989652125 0.9212020613004572 0.997821860734341 0.8035013166945769 0.7830089157395098 0.88791542791125 0.8901209663762094 0.8636253649593207 0.8485481235130038 1.276308420862176 1.0 12.363433932087894 -8.245526423391896 24.911871281104766 1.1381542128094508 0.8737741880646959 0.6131271709184086 0.08378160600854744 424.89436308076677 665178.675712066 0.05605501864864233 0.021031191569236433 5.681638222234849e-09 8.245526423391896 -0.26438002474475497 ELISNSSDALDK ddPTM_A459_Selumetinib_30min_R1 2 ELISNSSDALDK 12 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 ; 155.48 0.0059058 23266700.0 2792.0 2985.32 2442.9 2893.6000000000004 2775.3999999999996 2683.7 2923.8 2479.3 1637.47 2141.7200000000003 False True 2857.048167713714 2635.7973465623845 2111.167597889175 2388.2870795991876 2524.3655600366687 2656.704414604638 2703.255412035114 2413.5409100986094 2778.6669939230624 2416.6306241194316 1.1822444601995232 1.090691030832572 0.8735996212323259 0.9882714618289786 1.0445806383656557 1.0993423604290722 1.1186051294124117 0.9987214785784865 1.1498103873179002 1.0 11.23878126232702 -6.548257364068054 8.470661272595816 1.0756955719431172 1.0250979317277864 0.042951048966790806 0.0853546685184544 0.7019412256756078 203.0908068005909 0.02946783859966475 0.029709737493459124 2.829714602415536e-07 6.548257364068054 -0.05059764021533075 ELISNSSDALDK ddPTM_A459_Selumetinib_30min_R2 1 ELISNSSDALDK 12 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 145.99 0.030216000000000007 0.0 19254.0 18011.0 18270.0 18385.0 23271.0 18985.0 18829.0 18347.0 18232.0 14234.0 False True 18183.939759868874 19392.385785507126 17094.528090871947 15880.931284106016 20347.488934620415 21600.01142132898 19704.585808955675 18400.38673249063 21878.909444643155 13823.02743562656 1.3154817093831983 1.4029043837044313 1.2366703437782114 1.1488750462272506 1.4719994609992697 1.562610761059371 1.4254898864029144 1.3311401440951125 1.5827870954125358 1.0 13.754786000198937 -4.7169775587846114 20.5597962560637 1.364506729512044 1.3154772013125993 0.0 0.1733370107613789 9046.465647099663 4180667.204898923 0.04279789335113298 11.507240542922261 1.9187678862333272e-05 4.7169775587846114 -0.04902952819944484 ELKAEDEDIVLT(ph)PDGTR ddPTM_A459_Selumetinib_30min_R1 1 ELKAEDEDIVLTPDGTR 17 1 F5GZI3;Q8TEW0-11;Q5VWV2;Q8TEW0-6;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-9 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 ELKAEDEDIVLT(0.987)PDGT(0.013)R 96.55 0.0082336 5228100.0 1234.9 1864.8 1642.7 1529.8 1830.5 1653.9 1561.3 1497.9 1029.4 1430.0 True False 1263.670767302888 1646.4683490779992 1419.6303627052064 1262.6491479025553 1664.9315982010237 1637.26326762105 1443.5298839901586 1458.1708261350823 1746.8166155986974 1613.554429379559 0.7831596779718131 1.0203983944384796 0.8798156026574697 0.7825265295748758 1.031840988990511 1.0146935472456344 0.8946273256770285 0.90370104632651 1.08258921037475 1.0 10.656026529156621 -6.2775279708622405 24.988676236647436 0.9797689120659907 0.8784224635161425 0.34148906487901765 0.08147275388110038 1148.538118997328 1783896.1017568184 0.02571293277832661 0.02924335546440299 5.278032123676944e-07 6.2775279708622405 -0.1013464485498482 ELKEQYS(ph)DAPEEIR ddPTM_A459_Selumetinib_30min_R2 1 ELKEQYSDAPEEIR 14 1 Q8NEJ9-2;Q8NEJ9;H0YJ17 Q8NEJ9-2 NGDN Neuroguidin 1 ELKEQY(0.077)S(0.923)DAPEEIR 75.564 0.024213 7996600.0 25899.0 15857.0 15639.0 22432.0 23083.0 17687.0 23295.0 18105.0 14987.0 17318.0 True False 24459.63726191148 17073.18091170876 14632.803766455743 19376.722902641617 20183.107175361747 20123.22370339983 24378.263658166794 18157.6825525559 17984.81877176761 16817.984342432268 1.454373887136944 1.0151740282355137 0.8700688185050066 1.1521429981209803 1.2000907340863183 1.196530053404102 1.4495353998314602 1.0796586667489951 1.06938015909501 1.0 14.037717186603107 -5.9882235943043 24.98733167687835 1.1847065286751632 1.08801971027883 0.004807974871395393 0.17776023024914406 764.3280507615226 1621745.9779805408 0.05113909873872703 0.0757899946879974 1.0274871653883094e-06 5.9882235943043 -0.0966868183963332 ELKTDSS(ph)PNQAR ddPTM_A459_Selumetinib_30min_R1 4 ELKTDSSPNQAR 12 1 A6NLN1;P26599;P26599-2;P26599-3;K7ES59;A0A087WU68 A6NLN1 PTBP1 Polypyrimidine tract-binding protein 1 1 ELKTDS(0.027)S(0.973)PNQAR;ELKT(0.002)DS(0.093)S(0.905)PNQAR;ELKT(0.001)DS(0.084)S(0.916)PNQAR;ELKT(0.001)DS(0.071)S(0.928)PNQAR 209.67 3.2405e-05 162346000.0 15421.7 13367.3 46347.3 47806.0 30552.5 24295.5 19411.7 19164.4 13609.0 13400.7 True False 15780.995604595477 11802.250301710823 40053.59122749559 39457.5795297618 27789.03176948199 24051.109328549024 17947.45984055066 18656.097857255594 23093.479037966456 15120.810378871773 1.0436607039690264 0.7805302762213091 2.6489050668515928 2.609488416367926 1.8378004269077703 1.590596583510862 1.1869376965158263 1.2338027784095262 1.5272646412016944 1.0 13.884247840421269 -7.049474354025067 3.3610100489523997 1.2589316595761295 1.8185929126513474 0.17286558694009957 0.5604642462026527 0.5150711938069894 11.670686687738895 0.25196834939245516 0.1984292382361339 8.923303119569121e-08 7.049474354025067 0.5596612530752179 ELLAKPIGPDDAIDALSSDFTCGS(ph)PTAAGK ddPTM_A459_Selumetinib_30min_R1 2 ELLAKPIGPDDAIDALSSDFTCGSPTAAGK 30 1 P20810-5;F8W7E0;E9PCH5;P20810-2;P20810-3 P20810-5 CAST Calpastatin 1 ELLAKPIGPDDAIDALSSDFT(0.026)CGS(0.966)PT(0.007)AAGK;ELLAKPIGPDDAIDALS(0.083)S(0.221)DFT(0.156)CGS(0.478)PT(0.062)AAGK 167.17 9.459199999999999e-28 412070000.0 11729.099999999999 13997.5 15550.8 16604.199999999997 14424.4 12587.1 14210.5 13099.9 7454.5 10868.900000000001 True False 12002.365209144305 12358.666192738798 13439.086774429978 13704.58816943628 13119.715566834666 12460.485202172391 13138.590544060811 12752.448097527833 12649.742044861567 12264.02918705138 0.97866410998244 1.0077166324577356 1.0958133391120146 1.1174621293225453 1.069772043651587 1.0160188802655847 1.0713110955356182 1.03982532192537 1.0314507452589423 1.0 13.582145415119653 -10.154275679480232 15.104028777975945 1.0000005173523436 1.0500594849986697 0.11023762040453022 0.03997092736167116 0.0 0.0 0.04195461427505248 0.010175488596358114 7.010101731013673e-11 10.154275679480232 0.050058967646326114 ELLAQY(ph)T(ph)KQY(ph)EEK ddPTM_A459_Selumetinib_30min_R1 1 ELLAQYTKQYEEK 13 1 H7C345;H7C2M3;A0A0C4DG10;Q9NUZ1-2;Q9NUZ1;Q9NUZ1-4 H7C345 ACOXL Acyl-coenzyme A oxidase-like protein 3 ELLAQY(1)T(1)KQY(1)EEK 81.565 0.028126 4661100.0 4255.5 2569.4 4823.7 4636.2 2805.2 2930.0 3080.5 2585.8 1986.7 2505.1 True False 4354.644870238433 2268.573453518348 4168.668034687465 3826.5747022524715 2551.4701552982865 2900.5268602271453 2848.1354048752205 2517.216184137854 3371.284797173044 2826.653986740371 1.5405652374382421 0.802564963437358 1.4747712504757868 1.353747122995123 0.9026467927334043 1.0261343885149392 1.0075995923928494 0.8905285881986026 1.1926768585711223 1.0 11.46487957704032 -6.259694155797363 24.993574181741902 0.9991510596356854 1.2708772854486994 0.3326435165794116 0.19996313607371838 196.92659804118463 2820209.611332649 0.05821140701936964 0.07128298159978746 5.499280145946444e-07 6.259694155797363 0.271726225813014 ELLDTS(ph)FEDLSKPK ddPTM_A459_Selumetinib_30min_R1 2 ELLDTSFEDLSKPK 14 1 P78345 P78345 RPP38 Ribonuclease P protein subunit p38 1 ELLDT(0.205)S(0.795)FEDLSKPK;ELLDT(0.256)S(0.742)FEDLS(0.002)KPK 109.48 0.0025052 137848000.0 7170.1 12040.4 7668.4 8991.7 7623.700000000001 8199.1 10487.099999999999 9049.8 4942.799999999999 8306.2 True False 7337.149379414074 10630.704370569896 6627.073399506054 7421.468390113358 6934.137681073556 8116.624498187162 9696.049603787345 8809.769906106727 8387.570592171402 9372.381679239505 0.7828479068096836 1.1342585838258878 0.7070853094027845 0.7918444472393223 0.7398479829767461 0.8660151470533969 1.0345342235970594 0.9399713122675101 0.8949241376661463 1.0 13.194199992121103 -7.0721187023360335 7.411096445549554 0.9613949365695228 0.8354313593043983 0.24041071172055895 0.11458768896889504 0.4741602438758841 43.04808795766034 0.045087488222359244 0.03499782151996293 8.469958796981053e-08 7.0721187023360335 -0.12596357726512453 ELLETLGMMDMLFATMR ddPTM_A459_Selumetinib_30min_R1 1 ELLETLGMMDMLFATMR 17 0 H0Y8P4;Q8TED0-3;Q8TED0;Q8TED0-2 H0Y8P4 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 107.03 0.002664 5165000.0 1709.9 1512.1 1387.9 1550.7 1596.6 1245.0 1565.7 1450.4 877.51 1200.0 False True 1749.7373431137812 1335.0626290437817 1199.4308031889914 1279.8993552441452 1452.1878119026246 1232.476430369555 1447.5979884476976 1411.9306804368255 1489.0703792053746 1354.0316889898395 1.2922425356375178 0.985990682418807 0.8858218112190666 0.9452506655874503 1.072491747210151 0.9102271685303248 1.0691020012446402 1.0427604404814048 1.099730819679914 1.0 10.40304578798675 ELLHSVHPES(ph)PNLK ddPTM_A459_Selumetinib_30min_R1 1 ELLHSVHPESPNLK 14 0 Q9Y217 Q9Y217 MTMR6 Myotubularin-related protein 6 1 ELLHSVHPES(1)PNLK 103.77 0.004403 12063000.0 1997.4 2458.9 2842.8 3229.8 3439.1 2087.0 2707.1 2523.8 1235.1 1363.5 True False 2043.9355337361644 2171.010844888404 2456.763374382638 2665.7760608548015 3128.034012222419 2066.006674844385 2502.901267501287 2456.8606255422374 2095.8744918651164 1538.518506614705 1.3285089031743653 1.411104796955228 1.5968370635907414 1.7326902792482288 2.0331468219418567 1.342854613683097 1.6268255836639698 1.596900274503825 1.362267975883368 1.0 10.587326082406133 -8.600636397789618 2.240450763742082 1.0006185697800785 1.592810722052535 0.4588880758819671 0.19519440014702927 0.3719853624105932 4.23106801660904 0.19817511506635666 0.05434609754263402 2.5082083089936613e-09 8.600636397789618 0.5921921522724565 ELLHSVHPES(ph)PNLK ddPTM_A459_Selumetinib_30min_R2 2 ELLHSVHPESPNLK 14 0 Q9Y217 Q9Y217 MTMR6 Myotubularin-related protein 6 1 ELLHSVHPES(1)PNLK;ELLHSVHPES(1)PNLK 120.55 0.0010685 23941000.0 55168.0 51732.0 72077.0 98821.0 98573.0 62245.0 57230.0 67661.0 61472.0 84129.0 True False 52101.983415001865 55699.67805540249 67439.6442915041 85361.40932426671 86189.37848619913 70818.68374614806 59891.308399093614 67857.8823081185 73768.11767118835 81699.97717660728 0.637723353366125 0.6817587957827567 0.8254548730867177 1.04481558348229 1.0549498477813195 0.8668139966925865 0.7330639550807851 0.830574066886617 0.9029147892137964 1.0 16.318048054894703 -5.337150882974404 3.26521629195912 0.9088445597121247 0.652406917943769 0.5394757776643548 0.09426486954681969 0.21559252649647398 4.429189838478231 0.028992384463854468 0.07291603962125186 4.600966986075766e-06 5.337150882974404 -0.2564376417683557 ELLS(ph)PGVK ddPTM_A459_Selumetinib_30min_R1 1 ELLSPGVK 8 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 ELLS(1)PGVK 93.556 0.023898 6130100.0 1759.7 2134.2 2361.1 2284.6 2011.7 2730.4 2006.2 1801.6 1777.0 1597.7 True False 1800.69758621985 1884.3268718373374 2040.4755885939373 1885.6374972533536 1829.742090194481 2702.934655004845 1854.8707187991126 1753.8157155784522 3015.4392130550664 1802.7803579158874 0.9988446891564511 1.0452337488387782 1.131849245879758 1.0459607511107196 1.0149556390273538 1.4993144578797082 1.0288944577493868 0.9728393744016376 1.672660343682177 1.0 10.81600792111726 ELLS(ph)PGVK ddPTM_A459_Selumetinib_30min_R2 1 ELLSPGVK 8 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 ELLS(1)PGVK 114.4 0.010337 3649700.0 45328.0 45579.0 44169.0 44661.0 51369.0 40857.0 40668.0 39052.0 35770.0 43899.0 True False 42808.851222360834 49074.76274041582 41327.21462757108 38578.094755477745 44915.56697531335 46484.68088708129 42559.14258211321 39165.634854593394 42924.999497306184 42631.52180670021 1.00415958446111 1.1511379528727719 0.9694050992351827 0.9049194849388321 1.0535764399631204 1.0903828650042582 0.9983022134439585 0.9187013082051858 1.0068840538214108 1.0 15.379632935292138 -7.522024075188061 24.980234475435537 0.9693759556638961 1.0286861817478417 0.11734291701237032 0.0661566680704385 69.56939611875906 2033581.6054715812 0.03246752318540136 0.019027519521033914 3.005909664898783e-08 7.522024075188061 0.05931022608394554 ELLS(ph)PLSEPDDR ddPTM_A459_Selumetinib_30min_R2 1 ELLSPLSEPDDR 12 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 ELLS(0.979)PLS(0.021)EPDDR 89.44 0.025775 536710.0 3401.4 3472.7 4113.3 5458.3 4361.2 3487.5 3962.8 4464.0 4051.9 3896.3 True False 3212.363804883035 3739.0449235095566 3848.654756222421 4714.870123907305 3813.3070663773174 3967.871468627067 4147.078052139233 4476.989500945016 4862.393219545284 3783.8036951968397 0.8489773951436247 0.9881709583020652 1.0171391187941128 1.2460662612842102 1.0077972784946347 1.04864622698685 1.096007717684597 1.1831981417609232 1.2850543028216834 1.0 11.88562152785516 -4.9493188710139 1.3293458509532983 1.122221924667288 0.7871113819701979 0.4566833678304555 0.09272824764246133 0.9268870091884005 1.8149217291363362 0.028568291321989382 0.3890266095759685 1.123779560964969e-05 4.9493188710139 -0.33511054269709006 ELLSPLS(ph)EPDDRYPLIVK ddPTM_A459_Selumetinib_30min_R1 2 ELLSPLSEPDDRYPLIVK 18 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 ELLS(0.003)PLS(0.997)EPDDRYPLIVK;ELLS(0.003)PLS(0.997)EPDDRYPLIVK 135.26 0.00019864 202549000.0 6640.0 7828.5 7945.5 8499.7 7279.5 6528.4 7949.099999999999 7177.3 4099.3 5783.4 True False 6794.699080809117 6911.93558062909 6866.544741507406 7015.386954129528 6621.070510300108 6462.730223312932 7349.492987142875 6986.9346888439295 6956.212698973909 6525.755725086527 1.0412125992838974 1.059177798221591 1.0522221533838305 1.0750305787819707 1.0146059382589467 0.9903420378529785 1.1262286387597547 1.070670583329456 1.0659627776492775 1.0 12.67192926951723 -7.256765715658674 24.995128883985704 1.0716047136867703 1.040854993457123 0.10813087221892814 0.0360795257544658 803.167743097737 4295411.991242243 0.014136760170059293 0.010601509997330338 5.536486997934835e-08 7.256765715658674 -0.030749720229647393 ELLSPLS(ph)EPDDRYPLIVK ddPTM_A459_Selumetinib_30min_R2 4 ELLSPLSEPDDRYPLIVK 18 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 ELLS(0.035)PLS(0.898)EPDDRY(0.067)PLIVK;ELLS(0.029)PLS(0.971)EPDDRY(0.001)PLIVK;ELLS(0.045)PLS(0.952)EPDDRY(0.002)PLIVK;ELLS(0.439)PLS(0.561)EPDDRY(0.001)PLIVK 100.46 0.0042527 30996400.0 68838.0 67721.7 78740.0 80608.0 81858.0 72390.9 66041.7 67098.0 63041.8 72892.0 True False 65012.259540347564 72915.7366304134 73673.95412562971 69629.05134344392 71574.26622019506 82362.08937583798 69112.7699091459 67293.24407132812 75651.92153506515 70787.4185638394 0.9184154594042228 1.030066332545445 1.0407775226212987 0.9836359731164542 1.0111156427557257 1.163513107934004 0.9763425663957047 0.9506384811962021 1.0687198808759881 1.0 16.11120534453972 -4.759767817307404 24.6373446751442 1.0250141253896232 0.9184153036692405 0.2432329042868604 0.05638958671153714 54.65582764386218 805279.1371705472 0.014268339798694902 0.08814318967674968 1.738730140927911e-05 4.759767817307404 -0.10659882172038271 ELLTTMGDRFTDEEVDELYR ddPTM_A459_Selumetinib_30min_R1 3 ELLTTMGDRFTDEEVDELYR 20 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 ;; 154.52 9.8263e-06 14386800.0 2709.0 2192.37 4563.799999999999 4533.5 3721.1 2909.99 2378.27 2115.25 1172.5700000000002 1638.6399999999999 False True 2772.114429203598 1935.686301194838 3944.0610271589553 3741.8093293347083 3384.527162013566 2880.71814265952 2198.875179143838 2059.146698699666 1989.7656488756209 1848.975405705259 1.4992705801547555 1.046896727356146 2.133106267930353 2.023720444192421 1.8304879294609102 1.558007820856179 1.189239820258786 1.1136690581961748 1.0761450058967441 1.0 10.85251031940796 -7.245792571573561 2.558414046865032 1.0790297677966776 1.7111922522583798 0.5204329853852206 0.28048198331102797 0.2723341196784302 3.522773199815803 0.1442215552465753 0.09739421379507224 5.678157417176442e-08 7.245792571573561 0.6321624844617022 ELLVSQHTVQLVGGLS(ph)PLSSPSDTK ddPTM_A459_Selumetinib_30min_R1 2 ELLVSQHTVQLVGGLSPLSSPSDTK 25 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 ELLVSQHTVQLVGGLS(0.999)PLS(0.001)SPSDTK;ELLVSQHTVQLVGGLS(0.997)PLS(0.002)S(0.001)PSDTK 209.75 2.8816999999999996e-32 203450000.0 9973.5 10792.0 6460.7 6764.5 12686.5 7983.1 14089.5 10089.099999999999 2067.0299999999997 6305.0 True False 10205.863144947254 9528.467622935319 5583.37242608481 5583.207060391449 11539.008314983497 7902.797262074855 13026.717671478475 9821.504293984543 3507.598940101977 7114.308165900783 1.4345545493607432 1.3393386118141068 0.7848089084538367 0.7847856643534259 1.6219438413267664 1.1108314508996584 1.8310589543922418 1.380528375346387 0.49303443965416976 1.0 12.796507752706452 -8.251082246452212 24.477046590921887 0.7465172063016388 1.2778772972437773 0.2960533772210955 0.3325539832491766 625.7116737594085 1478757.6772076236 0.24225095430045882 0.08922974151853313 5.609417351328841e-09 8.251082246452212 0.5313600909421385 ELNDWLT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 ELNDWLTK 8 0 Q4G0X0;A0A087WV90;A0A5H1ZRP8;A0A087WTU7;A0A075B6G3;P11532-4;P11532-11;P11532 Q4G0X0 DMD Dystrophin 1 ELNDWLT(1)K 112.11 0.026458 8745700.0 37510.0 48759.0 66097.0 25474.0 27124.0 62634.0 27100.0 24331.0 28951.0 47970.0 True False 35425.34436442717 52498.65851510422 61844.3909809722 22004.397254898904 23716.44062836339 71261.26496515766 28360.20369763126 24401.799181786104 34742.008958526996 46584.98145897192 0.7604456040328532 1.1269438533820297 1.3275607082819056 0.4723495977835368 0.5091005703039897 1.5297046973801742 0.6087842650019838 0.5238125768768874 0.7457770266394718 1.0 15.507577298657983 -5.756813096160717 24.999753412075673 0.7641661865364289 1.0771793615517335 0.15509984251420328 0.32243165486393893 224.65799953267586 1213999.5581507331 0.09142152863875264 0.1518462480593655 1.7505999182041082e-06 5.756813096160717 0.3130131750153047 ELNFSHLPSNSVS(ph)PGDCLLTTTLGK ddPTM_A459_Selumetinib_30min_R1 1 ELNFSHLPSNSVSPGDCLLTTTLGK 25 0 H0YNU5;A0A3B3IT82;P54132 H0YNU5 BLM Bloom syndrome protein 1 ELNFSHLPS(0.16)NS(0.16)VS(0.678)PGDCLLTTTLGK 75.17699999999998 0.00020613 8164200.0 970.63 1023.2 1342.1 1191.1 1165.9 921.3 1044.8 1118.2 621.57 763.39 True False 993.2437904827935 903.4032683272256 1159.8501916275993 983.0967447161285 1060.444550856363 912.032558473471 965.9898948266939 1088.541703574503 1054.7588923233757 861.3785425482938 1.153086292983792 1.04878775556053 1.3465046252444481 1.1413062853965978 1.2311016567920932 1.0588057554525596 1.1214464339556438 1.2637204780539015 1.2245010064947606 1.0 9.750503575410757 ELNFVTDSVEQELPS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 ELNFVTDSVEQELPSSPK 18 0 B4DP81;Q8TAP6-2;Q8TAP6 B4DP81 CEP76 Centrosomal protein of 76 kDa 1 ELNFVTDSVEQELPS(0.5)S(0.5)PK 98.592 0.005970399999999999 0.0 250.61 413.79 399.82 381.66 297.66 279.03 392.75 359.41 328.88 292.28 True False 256.4487253978272 365.3432744342481 345.5266400540548 315.0102456455023 270.7367055561412 276.22321153896945 363.12455129516076 349.8772792717871 558.0853395551775 329.7969850482919 0.7775957241097144 1.1077823357928853 1.0476949630193242 0.9551641158859461 0.8209192861981363 0.8375552963242593 1.1010547935785062 1.060886833821585 1.6922087370612484 1.0 8.36543439972124 -8.044657554301757 10.247071842584756 1.3569214799559877 0.9596828030528389 0.40610575371700386 0.1888988531321036 0.6404914524618102 143.77016486245887 0.12030660805327335 0.04585887731458065 9.022823161371482e-09 8.044657554301757 -0.39723867690314874 ELNFVTDSVEQELPS(ph)SPKQPICFDR ddPTM_A459_Selumetinib_30min_R1 1 ELNFVTDSVEQELPSSPKQPICFDR 25 1 B4DP81;Q8TAP6-2;Q8TAP6 B4DP81 CEP76 Centrosomal protein of 76 kDa 1 ELNFVTDSVEQELPS(0.885)S(0.114)PKQPICFDR 72.654 0.00035982 25689000.0 1018.0 1144.6 1567.4 1661.4 1170.1 1242.9 1067.6 1079.7 733.49 1105.3 True False 1041.7174193168194 1010.5896998898958 1354.555689111914 1371.267678340506 1064.264661597934 1230.397554462907 987.0700724703086 1051.0628486401279 1244.6789580099944 1247.1760215337247 0.8352609425859223 0.8103023810922174 1.0860982457361057 1.0994981098611716 0.8533395793555637 0.986546833180625 0.7914440747958346 0.8427542147158786 0.997997825903789 1.0 10.284449380521348 ELNFVTDSVEQELPS(ph)SPKQPICFDR ddPTM_A459_Selumetinib_30min_R2 1 ELNFVTDSVEQELPSSPKQPICFDR 25 1 B4DP81;Q8TAP6-2;Q8TAP6 B4DP81 CEP76 Centrosomal protein of 76 kDa 1 ELNFVTDSVEQELPS(0.5)S(0.5)PKQPICFDR 119.25 4.261e-08 3654200.0 20180.0 18150.0 22257.0 16628.0 22207.0 14624.0 14256.0 12643.0 14018.0 20551.0 True False 19058.476386940565 19542.046638551692 20825.00885158932 14363.237715100064 19417.158126901108 16638.323256545445 14918.932247728097 12679.78903683867 16821.991695645444 19957.639232089477 0.9549464325568544 0.9791762648525301 1.0434605320505652 0.7196862087779254 0.9729185852643663 0.8336819331713857 0.7475299094363953 0.6353351160116723 0.8428848472517586 1.0 14.28465345545571 -5.982984978270279 0.9390405017848203 0.7908654182463869 0.9966623411695223 0.2214521416030233 0.1154985047180657 0.8169680540330339 1.451629472417069 0.05055661616937494 0.11495445651507978 1.0399561360531337e-06 5.982984978270279 0.20579692292313545 ELNFVTDSVEQELPSS(ph)PKQPICFDR ddPTM_A459_Selumetinib_30min_R1 1 ELNFVTDSVEQELPSSPKQPICFDR 25 1 B4DP81;Q8TAP6-2;Q8TAP6 B4DP81 CEP76 Centrosomal protein of 76 kDa 1 ELNFVTDSVEQELPS(0.102)S(0.898)PKQPICFDR 181.67 5.6805e-21 25624000.0 1671.9 1911.0 2301.0 2059.3 1793.5 1297.8 1349.3 1635.0 847.34 1385.2 True False 1710.8520170489107 1687.2592316002022 1988.5368384882684 1699.6819128485633 1631.2782416681432 1284.7453103081193 1247.5212146723384 1591.6344887715186 1437.8740927349918 1563.0039129906045 1.0945922801788885 1.0794977655378042 1.2722532694646056 1.0874457182877062 1.0436814828869525 0.8219719091105322 0.7981561685826934 1.0183176609750983 0.9199427338501072 1.0 10.610105674800735 -6.485256902439154 3.035646759439586 0.9065388920221722 1.1388496634236418 0.6141940188075261 0.08246766495403202 0.17712598014946884 3.280781387197132 0.02906937200858149 0.03172065671392896 3.2714711711374915e-07 6.485256902439154 0.2323107714014696 ELNS(ph)NHDGADETSEK ddPTM_A459_Selumetinib_30min_R2 2 ELNSNHDGADETSEK 15 0 Q01105-2 Q01105-2 SET Protein SET 1 ELNS(1)NHDGADETSEK;ELNS(1)NHDGADETSEK 104.09 0.0034590000000000003 12786300.0 59286.0 43159.0 53267.0 55501.0 60665.0 51499.0 67031.0 67281.0 59262.0 51542.0 True False 55991.12146066194 46469.15652194226 49839.859212724456 47941.66805543471 53043.720348018905 58592.51978862375 70148.07431940665 67476.77657103089 71116.05591862895 50053.84853780136 1.1186177106516928 0.9283832887864379 0.9957248177447275 0.9578018365406709 1.059733105396672 1.1705897048929987 1.4014521633921886 1.3480836847155018 1.420790968049562 1.0 15.61119337873947 -6.893115273024369 2.4677333584721106 1.3204820424634809 0.9979743366650419 0.5427434453361364 0.12034371637888987 0.18988577702254278 2.35108005108525 0.04528194672327383 0.0386272079170402 1.2790417682254243e-07 6.893115273024369 -0.322507705798439 ELNSNHDGADET(ph)SEKEQQEAIEHIDEVQNEIDR ddPTM_A459_Selumetinib_30min_R1 3 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 ELNSNHDGADET(0.5)S(0.5)EKEQQEAIEHIDEVQNEIDR;ELNSNHDGADET(0.847)S(0.153)EKEQQEAIEHIDEVQNEIDR;ELNSNHDGADET(0.5)S(0.5)EKEQQEAIEHIDEVQNEIDR 122.0 2.0484999999999999e-19 35177000.0 1679.19 2769.8900000000003 1534.27 1647.15 2365.91 2266.01 2784.86 2021.52 761.0500000000001 2068.29 True False 1718.3118598650385 2445.5899911130737 1325.924561141849 1359.5061733348775 2151.913858235337 2243.215996772463 2574.7957680963523 1967.902722777614 1291.4462651072358 2333.775168350661 0.736279948114888 1.0479115658949423 0.5681458004709657 0.5825351952371983 0.92207419438615 0.9611962742571306 1.1032749868171865 0.8432272094866712 0.5533721853849076 1.0 11.18844986578904 -6.312523286839125 24.97871487851112 0.9028567155556071 0.744333620294315 0.1619666228695713 0.1812505379872517 726.3328627631856 355156.17053364596 0.05962902796219735 0.06761303658262152 4.869414147019449e-07 6.312523286839125 -0.15852309526129205 ELNSNHDGADET(ph)SEKEQQEAIEHIDEVQNEIDR ddPTM_A459_Selumetinib_30min_R2 1 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 ELNSNHDGADET(0.5)S(0.5)EKEQQEAIEHIDEVQNEIDR 98.033 2.3196e-11 19642000.0 21057.0 15716.0 23680.0 30011.0 35805.0 27307.0 30068.0 23114.0 30277.0 26574.0 True False 19886.736237849716 16921.36666509522 22156.454580834594 25923.45002813738 31306.85579923871 31068.29138173458 31466.22157861169 23181.257913271307 36333.2460100626 25806.739572456117 0.7706024305013369 0.6556956417367664 0.858553034901103 1.0045224796938637 1.213127125623143 1.2038828575964005 1.2193024806665627 0.8982637209240092 1.407897572959645 1.0 14.655460262175605 -5.769991165721241 2.0049752736260658 1.1564217777097763 0.7154522258420656 0.6453436056768624 0.13284956426244088 0.1899866529204559 1.5588188677652093 0.03869442036304202 0.07567354825437003 1.698278197939624e-06 5.769991165721241 -0.4409695518677107 ELNSNHDGADETS(ph)EK ddPTM_A459_Selumetinib_30min_R1 1 ELNSNHDGADETSEK 15 0 Q01105-2 Q01105-2 SET Protein SET 1 ELNSNHDGADET(0.214)S(0.786)EK 108.34 0.0026571 3046700.0 3003.5 2894.6 1906.2 2049.5 3063.7 2415.4 3733.6 3126.3 1127.0 2652.9 True False 3073.4757062063545 2555.698886336967 1647.3485100071011 1691.5932988797806 2786.5888759401655 2391.1032690077286 3451.9715460613934 3043.380368346422 1912.4366871767365 2993.4255564342884 1.0267419878206092 0.8537706511002288 0.550322190731007 0.5651028452148228 0.930903015092681 0.7987849451836595 1.153184363860819 1.0166881757940354 0.6388789870073786 1.0 11.547581676934362 -6.323908555984585 24.008155547327817 0.9291990874535002 0.7422788383835678 0.18171343940809137 0.18047754237813435 258.937786879503 99513.91784828054 0.05919228055773026 0.06711775812822725 4.743418510405426e-07 6.323908555984585 -0.18692024906993243 ELNSNHDGADETS(ph)EK ddPTM_A459_Selumetinib_30min_R2 2 ELNSNHDGADETSEK 15 0 Q01105-2 Q01105-2 SET Protein SET 1 ELNSNHDGADET(0.175)S(0.825)EK;ELNSNHDGADET(0.249)S(0.751)EK 107.63 0.0027731 14085200.0 55339.0 34282.0 58398.0 77086.0 78399.0 62865.0 80019.0 81581.0 82941.0 57906.0 True False 52263.47991956904 36911.31916599606 54640.73625893488 66586.75381923272 68549.81672404737 71524.08311834853 83740.04205464035 81818.38720353844 99531.51756516808 56234.10332214361 0.92939118492157 0.6563867295001623 0.9716654668772623 1.18409914776773 1.2190079093348705 1.2718987036854574 1.489132698976736 1.4549602886851825 1.7699494023224696 1.0 15.779157701664184 -6.019097257938439 0.8791115939297068 1.4533015195523755 0.7529507087868316 0.5900286291211835 0.19629075631344423 0.42881543460825977 0.6716901271112029 0.08877107181691345 0.19938029552148342 9.569797367760256e-07 6.019097257938439 -0.700350810765544 ELNSNHDGADETS(ph)EKEQQEAIEHIDEVQNEIDR ddPTM_A459_Selumetinib_30min_R1 1 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 ELNSNHDGADET(0.265)S(0.735)EKEQQEAIEHIDEVQNEIDR 75.225 5.192e-06 10647000.0 1114.3 1297.1 731.32 802.48 1077.0 976.51 1342.8 997.74 339.84 970.89 True False 1140.261021949639 1145.23492899457 632.0107608532121 662.3419324152457 979.5855401597936 966.6871960001395 1241.5115149055175 971.2766940837278 576.6836590684492 1095.5131887694538 1.0408464577504983 1.0453867107533108 0.5769083999464438 0.6045951241894476 0.8941795956469706 0.8824058038826357 1.1332693459401049 0.8865951629251713 0.52640503553975 1.0 10.09739113755047 -10.767213699922133 3.940225422148162 1.0001384308106023 0.8469151486169934 0.052239345582222874 0.19960371486366654 153750365.5266824 234046.29086155604 224803.77763650456 0.05120081243087595 1.7091740880831313e-11 10.767213699922133 -0.15322328219360892 ELNSNHDGADETS(ph)EKEQQEAIEHIDEVQNEIDR ddPTM_A459_Selumetinib_30min_R2 1 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 ELNS(0.004)NHDGADET(0.464)S(0.533)EKEQQEAIEHIDEVQNEIDR 48.38800000000001 0.0056369 14962000.0 12054.0 7555.7 12335.0 16429.0 17657.0 9201.3 11389.0 18158.0 15275.0 15199.0 True False 11384.086935985206 8135.19789459531 11541.379529332547 14191.34185839422 15438.769804417201 10468.695553914908 11918.61106687536 18210.836773781273 18330.426819159948 14760.165378255457 0.7712709610121402 0.5511589935557233 0.7819275213769085 0.96146225294337 1.0459753945007593 0.7092532695695467 0.8074849272646871 1.2337827054844057 1.24188492130069 1.0 13.849421265517703 -6.227314269393018 0.4114203125275951 1.1346070806406432 0.5820066632494367 0.44336019780586255 0.15991997650381742 1.8740107027039632 0.5544250769687942 0.1695190416904793 0.4530691412185039 5.92496420033181e-07 6.227314269393018 -0.5526004173912065 ELNVS(ph)FINEK ddPTM_A459_Selumetinib_30min_R2 2 ELNVSFINEK 10 0 P49585;C9JEJ2;C9J050;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3 P49585 PCYT1A;PCYT1B Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B 1 ELNVS(1)FINEK;ELNVS(1)FINEK 134.61 0.0020716 4353400.0 22041.0 15810.900000000001 24622.0 27779.0 25173.0 20342.0 18656.4 20053.4 12327.099999999999 16460.8 True False 20816.049457113833 17023.545189943627 23037.84732640664 23995.452278552122 22010.542690524682 23143.925853709472 19523.95956695528 20111.752073980915 14792.864447951992 15985.533933705343 1.302180430346677 1.0649344126097438 1.4411684603059498 1.5010729311929922 1.3769038170264472 1.4478043679798978 1.221351732630538 1.2581220093984775 0.9253907006985472 1.0 13.964479312009718 -8.092878430358887 2.0335155774855953 0.955813779785631 1.3457882412139035 0.5899348592891138 0.12156661693314104 0.2537951685876945 1.8742540628474769 0.11510087628074389 0.036290761449885356 8.074610266948524e-09 8.092878430358887 0.3899744614282725 ELPDSS(ph)SPVPANNIR ddPTM_A459_Selumetinib_30min_R1 2 ELPDSSSPVPANNIR 15 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 ELPDS(0.039)S(0.481)S(0.481)PVPANNIR;ELPDS(0.038)S(0.481)S(0.481)PVPANNIR 87.363 0.018735 22868400.0 3758.4 4214.0 4310.4 4766.6 5361.7 3931.1000000000004 5316.6 4104.8 2031.04 3369.2 True False 3845.9634074266564 3720.622920964547 3725.0713553323912 3934.2027901636284 4876.735181685019 3891.5567031532173 4915.564581580783 3995.9273697304757 3446.526538707576 3801.6696387871393 1.0116511356451394 0.9786812833509518 0.9798514098454948 1.0348618275571078 1.282787734086453 1.02364410190959 1.2930015095022864 1.0510980041404416 0.9065823351781651 1.0 11.892417453368337 -6.009312839004709 24.352444288416663 1.1071242807443542 0.9919954628385137 0.1375714916843399 0.11310156995718272 565.0465213528709 1477568.6392604338 0.032573698279246506 0.04547857851741707 9.787846751931579e-07 6.009312839004709 -0.11512881790584051 ELPESGIQLGT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ELPESGIQLGTPR 13 0 A0A087WW69;F8W8L6;A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WW69 EIF2B4 Translation initiation factor eIF-2B subunit delta 1 ELPESGIQLGT(1)PR;ELPESGIQLGT(1)PR 172.43 0.0004114 30915000.0 3043.8999999999996 3373.6 3520.2 3622.2 3204.3999999999996 2890.1 3420.1 3085.7 1885.19 2303.6 True False 3114.8169476016346 2978.6173436559093 3042.1761750744913 2989.650767115072 2914.5625857827686 2861.028218000845 3162.1191034616936 3003.8572122338087 3199.0297411701076 2599.2894989641622 1.198333986592457 1.1459352045406686 1.1703875910270183 1.1501799889186919 1.121292024972303 1.1006962553193815 1.2165320964524435 1.155645499830192 1.230732376076211 1.0 11.343901609299618 -11.463410584461014 2.580413676955303 0.8857951438149131 1.162643345206185 0.6225590559610346 0.03860667138349421 9703783.73293991 6607761.0635599205 6688053.068462654 0.009690632430533901 3.4402453423009762e-12 11.463410584461014 0.276848201391272 ELPESGIQLGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 ELPESGIQLGTPR 13 0 A0A087WW69;F8W8L6;A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WW69 EIF2B4 Translation initiation factor eIF-2B subunit delta 1 ELPESGIQLGT(1)PR;ELPES(0.002)GIQLGT(0.998)PR;ELPESGIQLGT(1)PR;ELPESGIQLGT(1)PR 157.07 0.00085369 19996200.0 41842.3 43014.5 44905.7 47818.6 50228.0 40968.0 38842.0 38443.7 34317.4 48084.9 True False 39516.8724739982 46313.57383658301 42016.51615162935 41305.624188313945 43917.909595982754 46610.970129523615 40648.22996396285 38555.56480230287 41181.83890827102 46696.56399742586 0.8462479696830919 0.9917983224447957 0.8997774687222277 0.8845538226450861 0.9404955276453257 0.998167019999438 0.8704758227222794 0.825661708309593 0.8819029792115146 1.0 15.51102877774466 ELPPAAAIGATSLVAAPHSS(ph)SSSPSKDSSR ddPTM_A459_Selumetinib_30min_R2 1 ELPPAAAIGATSLVAAPHSSSSSPSKDSSR 30 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 ELPPAAAIGATSLVAAPHS(0.094)S(0.247)S(0.176)S(0.176)S(0.176)PS(0.068)KDS(0.036)S(0.026)R 88.194 7.2306e-07 6561600.0 8270.3 6146.4 15583.0 19705.0 23664.0 15860.0 8092.9 10239.0 14234.0 18723.0 True False 7810.669834634018 6617.80911620904 14580.40674548756 17021.14500697901 20691.11676115585 18044.57103725456 8469.235885777123 10268.793794842306 17081.1977311897 18182.418341803866 0.4295726612271493 0.3639674872617903 0.8018959013810176 0.9361320747881524 1.1379738587129602 0.9924186485010976 0.46579259846338433 0.5647650165012948 0.9394348655985816 1.0 14.150256476644495 -5.292120003769982 5.659227524246872 0.845105294043466 0.39479696797631125 0.4726201280127781 0.19351178920012377 0.1657738265479524 16.55731314571557 0.057170402687798286 0.1279187346025267 5.10363957286799e-06 5.292120003769982 -0.45030832606715476 ELPPAAAIGATSLVAAPHSSS(ph)SSPSKDSSR ddPTM_A459_Selumetinib_30min_R1 1 ELPPAAAIGATSLVAAPHSSSSSPSKDSSR 30 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 ELPPAAAIGATSLVAAPHS(0.006)S(0.177)S(0.262)S(0.262)S(0.262)PS(0.025)KDS(0.004)S(0.003)R 121.12 2.7444000000000003e-16 23563000.0 1154.6 1567.8 1584.4 1881.5 2525.0 1384.3 1979.5 1486.4 525.43 797.25 True False 1181.4999335394887 1384.2412471495545 1369.247182486229 1552.9313451292062 2296.614195824957 1370.375198843836 1830.1847212954078 1446.975843492347 891.6163341111561 899.5848033726247 1.3133836066482434 1.5387557036978714 1.522087942518368 1.7262756543987028 2.5529713121150364 1.5233418725018202 2.0344771437155007 1.6084929826154286 0.9911420588347045 1.0 9.81311547974313 -8.210972634167952 4.008522213059243 0.980258219763976 1.7533063493544248 0.4480929482098174 0.32704019557078146 0.20402334387824747 6.63822894580817 0.2747827098038966 0.08838395410878587 6.152156375528272e-09 8.210972634167952 0.7730481295904488 ELPPAAAIGATSLVAAPHSSS(ph)SSPSKDSSR ddPTM_A459_Selumetinib_30min_R2 1 ELPPAAAIGATSLVAAPHSSSSSPSKDSSR 30 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 ELPPAAAIGATSLVAAPHS(0.038)S(0.103)S(0.277)S(0.277)S(0.277)PS(0.025)KDS(0.002)S(0.001)R 104.03 2.246e-09 4861000.0 18383.0 15465.0 27574.0 40168.0 51533.0 22635.0 14959.0 20738.0 27544.0 40586.0 True False 17361.3464529796 16651.115772187426 25799.918860301215 34697.04910633508 45058.963829134744 25752.765789927937 15654.623140696161 20798.344146639283 33053.569643662326 39414.17672490796 0.44048481778912874 0.4224651421341165 0.6545847460007163 0.8803190118241929 1.1432171764901926 0.6533883980292139 0.3971825480450326 0.527686885147995 0.8386213385696315 1.0 15.266427019688134 -14.5228784522311 0.0425902520756242 2.13157601536485 1.636634710507041e-09 0.18863441823035454 0.2221049059126897 1792.1536973587047 5.666621078982027 265.2913380786881 73.59022017972441 3.0000020243131063e-15 14.5228784522311 -2.1315760137282154 ELPPLS(ph)PSLSR ddPTM_A459_Selumetinib_30min_R1 4 ELPPLSPSLSR 11 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 ELPPLS(0.561)PS(0.287)LS(0.152)R;ELPPLS(0.886)PS(0.114)LSR;ELPPLS(0.977)PS(0.023)LSR;ELPPLS(0.866)PS(0.132)LS(0.002)R 142.76 0.00089481 144952100.0 8690.9 11080.699999999999 10820.500000000002 11668.499999999998 11269.599999999999 8499.4 9955.3 8559.3 5420.42 7855.299999999999 True False 8893.381060452399 9783.366492722327 9351.135532751987 9630.815519872505 10250.266669809476 8413.903752837747 9204.363705941985 8332.279559475262 9198.056848186796 8863.604272101567 1.0033594446950385 1.103768421105592 1.0550037259881895 1.0865574798037583 1.1564445292387957 0.9492643731084357 1.0384447932668843 0.9400554564130684 1.037733247764448 1.0 13.11367775636721 -6.774687587379802 24.99991161870916 0.9921871190833726 1.0811517017928363 0.47011532318429894 0.04666954094009418 203.11091387086842 383276.6090276364 0.01570392342491764 0.013926393355347965 1.6800121114167052e-07 6.774687587379802 0.08896458270946361 ELPPLS(ph)PSLSR ddPTM_A459_Selumetinib_30min_R2 3 ELPPLSPSLSR 11 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 ELPPLS(0.845)PS(0.155)LSR;ELPPLS(0.904)PS(0.096)LSR;ELPPLS(0.898)PS(0.102)LSR 166.24 0.00057195 99224000.0 330092.0 322281.0 385693.0 392666.0 452824.0 284680.0 325741.0 353826.0 284467.0 333553.0 True False 311746.8081029727 346998.91640325513 360877.93229078775 339184.21341336804 395936.20082207763 323892.08593225916 340888.60194354656 354855.57508095267 341368.348672077 323922.45821522723 0.9624118371435532 1.0712406861666102 1.1140874093114155 1.0471154586879563 1.2223178442261684 0.9999062359456784 1.0523771763828933 1.0954954375073684 1.053858230617829 1.0 18.305288971074134 -4.764234329518527 5.492679379257841 1.078528744924748 0.9569679291099646 0.2260013028000818 0.0607106251446243 0.21029787530383653 20.105127373943635 0.014568972943458157 0.09716144148768087 1.7209397678799885e-05 4.764234329518527 -0.1215608158147834 ELPPLSPS(ph)LSR ddPTM_A459_Selumetinib_30min_R1 1 ELPPLSPSLSR 11 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 ELPPLS(0.227)PS(0.772)LS(0.001)R 128.57 0.0027519000000000003 5486100.0 1565.1 2000.7 2016.3 1881.7 2091.7 1881.9 2136.3 1725.4 1097.6 1505.7 True False 1601.5637848455344 1766.4571138998044 1742.4975347431105 1553.0964188836701 1902.5061043196279 1862.9697946284864 1975.157171055003 1679.6367871109344 1862.5470344677772 1698.9712617599996 0.9426667895408903 1.0397215972151848 1.0256191931922505 0.9141393111469027 1.1197988730832222 1.096528138267976 1.1625606715730414 0.9886198930586758 1.0962793052416473 1.0 10.73044573408417 -6.275475154916496 24.981493577364265 1.0819534675783355 0.9879843862706981 0.3847146529130845 0.05947678335481898 857.6790186537959 1526531.972804569 0.01827890569688964 0.020833584533148437 5.303039293456442e-07 6.275475154916496 -0.09396908130763748 ELPPS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 ELPPSPEK 8 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816-3;P27816;P27816-6;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ELPPS(1)PEK 109.16 0.01257 6511300.0 4546.4 6625.6 4380.4 4683.8 3939.4 4737.1 4946.5 4592.5 2641.8 5016.1 True False 4652.322274245567 5849.871671842125 3785.565739814869 3865.862255815134 3583.081965557559 4689.449074942664 4573.381522550005 4470.691981457615 4482.941650562111 5659.965295951611 0.8219701059957422 1.0335525689576839 0.6688319701399161 0.6830187207296589 0.6330572323686192 0.8285296516388315 0.8080228912041556 0.789879751498716 0.7920440172607797 1.0 12.466577491869067 -9.726546166581345 0.8688262285850988 1.0060078208762873 0.7801575622600456 0.2718090465172759 0.10606382915142744 16.35132787960381 10.10441518991777 0.46409210861260525 0.03712991589800578 1.8769548828070042e-10 9.726546166581345 -0.22585025861624164 ELPPS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 ELPPSPEK 8 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816-3;P27816;P27816-6;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ELPPS(1)PEK;ELPPS(1)PEK 94.465 0.022674 27056000.0 174896.0 143447.0 147780.0 150126.0 149128.0 146794.0 170403.0 169389.0 143802.0 148181.0 True False 165175.98048416057 154448.92364519706 138271.99569069807 129678.57981820474 130393.20741876484 167013.54103674326 178327.07714713877 169881.89394614156 172566.41816359007 143902.62950952517 1.1478315653240185 1.0732877096938234 0.9608719184769698 0.9011550397668104 0.9061210894004816 1.160601037006682 1.239220421162179 1.1805336325344686 1.1991887761312074 1.0 17.134733428889533 -6.831119431535466 8.570639766404957 1.1732386124548555 0.9947972560880987 0.4246835514238305 0.09086785524126097 0.2655159424019695 29.511233284712695 0.03373461602924785 0.02978937448717419 1.4753007678959324e-07 6.831119431535466 -0.17844135636675684 ELPPS(ph)PEKK ddPTM_A459_Selumetinib_30min_R1 5 ELPPSPEKK 9 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816-3;P27816;P27816-6;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK 147.62 0.0029074 423652000.0 43122.7 62816.6 46368.7 50101.3 38625.8 46924.5 47813.6 46994.8 29523.7 51966.9 True False 44127.37500783244 55462.00326935494 40072.08522503737 41352.04847287904 35132.103209938876 46452.4821340371 44206.98165704977 45748.345243376025 50099.56257426779 58637.35781547176 0.7525471244236248 0.9458475848091676 0.6833883162188483 0.70521677670081 0.5991419893184391 0.7921994418681051 0.7539047341827114 0.7801911093494921 0.8543966583884646 1.0 15.8395324770117 -8.6021507047712 1.2946668343063938 0.9996592842724812 0.7457179383459516 0.46814821098481707 0.08321901869291774 0.5254089075407242 1.8905902914669213 0.08426649250473257 0.02562231173681775 2.49947786597705e-09 8.6021507047712 -0.2539413459265296 ELPPS(ph)PEKK ddPTM_A459_Selumetinib_30min_R2 6 ELPPSPEKK 9 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816-3;P27816;P27816-6;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK;ELPPS(1)PEKK 138.63 0.0044 359356700.0 1027983.0 993850.0 865721.0 928398.0 755504.0 720209.0 994048.0 877131.0 608205.0 964556.0 True False 970851.8202019982 1070075.0992685722 810021.453385754 801948.5908241203 660590.8332285447 819411.2523436364 1040273.2016687436 879683.3059931464 729862.9946675729 936706.7620625411 1.0364522383336625 1.1423800303441458 0.8647545701518821 0.8561362245942414 0.7052269290487294 0.8747788374446759 1.110564419731698 0.939123471315789 0.7791798076278242 1.0 19.837237954413006 -5.26655934103579 24.92303385475362 0.8883972333008394 1.0894161402274525 0.34872043096174166 0.1082875616640927 429.51990907679556 2090836.0045159836 0.030333276752934443 0.066399089368078 5.4130328034849985e-06 5.26655934103579 0.20101890692661306 ELPS(ph)FLGK ddPTM_A459_Selumetinib_30min_R1 1 ELPSFLGK 8 0 P26447 P26447 S100A4 Protein S100-A4 1 ELPS(1)FLGK 86.344 0.034003 6799700.0 1465.8 2719.5 2797.5 2875.8 2619.3 2525.4 2532.6 3612.3 1151.3 2085.0 True False 1499.9502880497 2401.09967573875 2417.61486556755 2373.5955154518033 2382.384777474975 2499.9967688797383 2341.5639429920416 3516.4900695959373 1953.6720123749578 2352.6300596198457 0.6375631739960308 1.0206023109841318 1.0276221948631419 1.008911497048263 1.0126474273902364 1.0626391338737315 0.9952962784851979 1.4947059165622307 0.8304204073166717 1.0 11.200058765822895 -4.4281288110695645 1.7549405155610107 1.0696700648635478 4.999950476784204e-11 0.3694750675683789 0.16066774328538164 2.9497424020765215 4.067194376056106 0.04227854733031494 7.150033778639853 3.731394687938863e-05 4.4281288110695645 -1.0696700648135482 ELPSLS(ph)PAPDTGLSPSKR ddPTM_A459_Selumetinib_30min_R2 1 ELPSLSPAPDTGLSPSKR 18 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8;A0A0A0MSL0 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 ELPS(0.055)LS(0.945)PAPDTGLSPSKR 85.166 0.003972 3150400.0 18815.0 21649.0 20354.0 22837.0 22641.0 10987.0 16476.0 14160.0 11158.0 18978.0 True False 17769.337622412622 23309.408687493396 19044.44579975959 19726.561203977642 19796.63516689189 12500.359519944246 17242.16664657463 14201.203255685812 13389.911780568691 18430.0558292343 0.9641499617286222 1.2647497600370434 1.0333363054468194 1.0703473384321922 1.0741494952766166 0.678259449443219 0.935546088754902 0.770545862002189 0.7265258393482029 1.0 14.169772820807683 -6.706058620948244 10.066439732742845 0.8150566918532375 1.088730786295136 0.5679380147972519 0.11285426129043219 0.28797161002818855 50.423194229128455 0.03531793025889005 0.03526867588610322 1.9676206828895632e-07 6.706058620948244 0.2736740944418986 ELPSLSPAPDTGLS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 1 ELPSLSPAPDTGLSPSKR 18 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8;A0A0A0MSL0 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 ELPSLSPAPDT(0.033)GLS(0.939)PS(0.027)KR 76.678 0.0073932 41731000.0 2037.2 2608.1 2417.0 2953.4 3552.6 2020.0 2503.7 1805.7 902.97 1702.7 True False 2084.6627962988464 2302.7424395272055 2088.7846756306576 2437.6441321842126 3231.267957262471 1999.680634013254 2314.843893259567 1757.806970259775 1532.2741396805477 1921.2581307024993 1.085050864839593 1.19855963273671 1.0871962711574332 1.2687749205739987 1.681849984458347 1.0408183065344165 1.2048583458242306 0.914924934952411 0.797536840674438 1.0 10.907835650029977 -7.750326145382476 3.216295466661072 0.8799557916074751 1.2351482287052893 0.41119606248825846 0.17490444201475328 0.24744454418715542 5.258258732269592 0.10674057785839909 0.05074700443957282 1.776944463540799e-08 7.750326145382476 0.35519243709781423 ELPSLSPAPDTGLS(ph)PSKR ddPTM_A459_Selumetinib_30min_R2 1 ELPSLSPAPDTGLSPSKR 18 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8;A0A0A0MSL0 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 ELPSLSPAPDT(0.351)GLS(0.641)PS(0.008)KR 123.61 0.00045377 14612000.0 48261.0 48405.0 62337.0 64750.0 66136.0 61828.0 57165.0 59751.0 45110.0 62116.0 True False 45578.846824090106 52117.5078533936 58326.30528739382 55930.93830001984 57827.40441665839 70344.24578129717 59823.28577029859 59924.86551768948 54133.260478710654 60322.549683249956 0.7555855490761226 0.8639805201713037 0.9669071614787788 0.9271978487930269 0.9586366080397228 1.166135154277638 0.9917234282109598 0.9934073714117078 0.8973967573148204 1.0 15.88040978855458 -4.576092626896376 0.8686784633251288 1.00308222382489 0.5345480930205758 0.5719864961243635 0.06595679393217513 2.3698993039913874 1.0948619323783462 0.024746776143753046 1.1528990828475714 2.654039444594885e-05 4.576092626896376 -0.46853413080431416 ELPVPGS(ph)AEEEPPSGGGR ddPTM_A459_Selumetinib_30min_R1 2 ELPVPGSAEEEPPSGGGR 18 0 P16383-3;P16383-4;P16383;C9JII4;P16383-2 P16383-3 GCFC2 GC-rich sequence DNA-binding factor 2 1 ELPVPGS(1)AEEEPPSGGGR;ELPVPGS(1)AEEEPPSGGGR 166.36 1.4754e-07 14813400.0 6959.799999999999 7957.200000000001 9126.1 9582.0 8029.9 7619.4 8010.1 6939.1 4280.9 5858.5 True False 7121.949798586642 7025.567324798085 7886.825746079005 7908.683576416714 7303.596962793987 7542.755753861679 7405.891708031489 6755.052526626574 7264.374635434682 6610.495541622479 1.0773700328127944 1.0627898136474245 1.1930763278517034 1.1963828621652177 1.1048486330271985 1.1410272809911595 1.1203232286295117 1.021867798577868 1.0989152915534248 1.0 12.690542708988788 -7.691705068912575 6.284846552048483 1.0455481897057521 1.1308102702364458 0.422254230617778 0.046884801169098995 0.21603738793042873 14.83524814114022 0.02392196795077764 0.013514421302177962 2.0337376613095754e-08 7.691705068912575 0.08526208053069362 ELPVPGS(ph)AEEEPPSGGGR ddPTM_A459_Selumetinib_30min_R2 2 ELPVPGSAEEEPPSGGGR 18 0 P16383-3;P16383-4;P16383;C9JII4;P16383-2 P16383-3 GCFC2 GC-rich sequence DNA-binding factor 2 1 ELPVPGS(0.999)AEEEPPS(0.001)GGGR;ELPVPGS(1)AEEEPPSGGGR 156.0 2.4665e-05 11020100.0 31250.0 29632.0 40069.0 33211.0 39485.0 26970.0 25520.0 31701.0 25098.0 33032.0 True False 29513.250103661674 31904.679118102657 37491.004163828584 28687.604507829474 34524.54129962129 30684.872690715976 26706.730566920643 31793.244661616944 30118.30129671203 32078.280332557017 0.9200384122121399 0.9945882007185352 1.1687348503460164 0.8942999503222664 1.0762591055911905 0.9565622711879964 0.8325486993084021 0.9911143718433439 0.9389001213429837 1.0 14.96930918274531 -6.98408911734096 24.145268470144366 0.9334224914422898 1.0126103259226173 0.13901311213687484 0.08323711884690282 288.45465545780263 437736.38974141644 0.028791768564093656 0.025383116312658504 1.0373155365586634e-07 6.98408911734096 0.07918783448032751 ELPVS(ph)PGHR ddPTM_A459_Selumetinib_30min_R2 1 ELPVSPGHR 9 0 Q16236-3;Q16236-2;Q16236;C9JBM0 Q16236-3 NFE2L2 Nuclear factor erythroid 2-related factor 2 1 ELPVS(1)PGHR 117.09 0.005055 4156500.0 73523.0 61077.0 81426.0 78693.0 98059.0 83926.0 69934.0 85235.0 79296.0 74879.0 True False 69436.8859958885 65761.40950649146 76187.13980992544 67974.87764700317 85739.95176141747 95486.04469562581 73186.06957159197 85483.01973858614 95157.41571535886 72717.04871099356 0.9548914212932137 0.9043465139496162 1.0477204611634254 0.9347859800686128 1.1790900934687558 1.3131177129468672 1.0064499435677385 1.1755567814410293 1.3085984291462684 1.0 16.150006027150553 -6.264977703614062 24.645947144603692 1.1721781748931555 0.9626642882160159 0.4798477660055218 0.1034977955904355 215.8503128627929 1503489.0067957863 0.031184167737294877 0.03678187425026072 5.432782223141825e-07 6.264977703614062 -0.20951388667713955 ELQELVQYPVEHPDK ddPTM_A459_Selumetinib_30min_R2 2 ELQELVQYPVEHPDK 15 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ; 167.92 9.7775e-05 18317100.0 141673.0 126754.0 147728.0 148535.0 154902.0 125109.0 134404.0 125830.0 119743.0 127095.0 False True 133799.3818219541 136475.62422165147 138223.34131408518 128304.27676283334 135441.82591854996 142341.6291235737 140654.05231647356 126196.14446772223 143694.94589896375 123425.43711753257 1.0840502974645565 1.105733367520439 1.1198934720600684 1.0395286397945254 1.0973574741288923 1.1532600770781802 1.1395872325939989 1.0224484305253159 1.1642247275343205 1.0 16.913280228903545 -11.02558669183777 3.306119955216978 0.9977025080404178 1.1016488191308729 0.33571236230673795 0.043391338263993495 4672074.117466062 5195150.59064379 68314.43048329177 0.01027339676606808 9.42786398054274e-12 11.02558669183777 0.10394631109045505 ELQGDGPPS(ph)SPTNDPTVK ddPTM_A459_Selumetinib_30min_R1 3 ELQGDGPPSSPTNDPTVK 18 0 A0A5F9ZHX5;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 ELQGDGPPS(0.923)S(0.076)PT(0.001)NDPTVK;ELQGDGPPS(0.406)S(0.406)PT(0.187)NDPTVK;ELQGDGPPS(0.495)S(0.495)PT(0.01)NDPTVK 329.79 3.683399999999998e-144 41972000.0 16864.0 18659.2 16641.5 17586.8 18024.699999999997 15669.199999999999 18733.8 18143.0 9436.7 16809.199999999997 True False 17256.898388368205 16474.57218957327 14381.675705216221 14515.595525122675 16394.36906751924 15511.582074495278 17320.694383331094 17661.788703230373 16013.39067070161 18966.824555473333 0.9098464710260797 0.8685993873876551 0.7582542698780879 0.7653150100412487 0.8643707869796398 0.8178270447500416 0.9132100279976909 0.9311937615900834 0.8442842197367488 1.0 14.211190541085122 -7.267241357862724 22.237306387626845 0.9164381842651866 0.8276899222996322 0.39093248593080565 0.05567306803151174 120.71784837638907 462668.3383438427 0.02355605950757862 0.01642427312594549 5.404538838355927e-08 7.267241357862724 -0.08874826196555441 ELQGDGPPS(ph)SPTNDPTVK ddPTM_A459_Selumetinib_30min_R2 4 ELQGDGPPSSPTNDPTVK 18 0 A0A5F9ZHX5;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 ELQGDGPPS(0.499)S(0.499)PT(0.001)NDPTVK;ELQGDGPPS(0.449)S(0.449)PT(0.102)NDPTVK;ELQGDGPPS(0.498)S(0.498)PT(0.004)NDPTVK;ELQGDGPPS(0.493)S(0.493)PT(0.013)NDPTVK 281.65 4.3736999999999986e-67 99334700.0 421629.0 389588.0 421212.0 451237.0 437999.0 340760.0 379001.0 395764.0 306139.0 382822.0 True False 398196.54809461656 419468.1468771388 394111.6785009502 389777.7421727567 382973.6498592592 387696.59688870556 396625.2974762338 396915.6077177425 367375.3542383505 371768.93416899175 1.071086127690303 1.128303385044176 1.0600984705241734 1.048440862989318 1.0301389241016417 1.0428429092799716 1.0668597104887287 1.0676405994087717 0.9881819605490649 1.0 18.5040466949555 -1.5228787455785477 0.12708078376528292 0.9845159951348067 1.3586936040099906 0.5006166295762786 0.02648060008430732 77.56127288956142 0.6726594367630888 0.15967782646432496 5.178433939013804 0.02999999997940037 1.5228787455785477 0.3741776088751839 ELQGDGPPSS(ph)PTNDPTVK ddPTM_A459_Selumetinib_30min_R1 1 ELQGDGPPSSPTNDPTVK 18 0 A0A5F9ZHX5;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 ELQGDGPPS(0.195)S(0.781)PT(0.024)NDPTVK 273.01 3.0373e-54 16597000.0 5248.1 6436.5 4844.6 5248.3 5541.6 4765.5 6024.8 5452.8 2771.3 4971.0 True False 5370.370518975052 5682.911587752328 4186.729929482949 4331.782927792512 5040.363258448941 4717.563396727803 5570.344485405692 5308.17403080938 4702.693692256337 5609.076271640408 0.9574429476253948 1.0131635428965786 0.7464205738565425 0.7722809813968987 0.8986084364609392 0.8410588781935253 0.9930948012900903 0.9463544037808159 0.8384078704782894 1.0 12.453547485433477 -7.24831773868017 24.540829771477785 0.9399938060746187 0.8689727096638132 0.15056686227155514 0.08451294402571796 1351.1300030121663 2526962.5650807302 0.0348934752023047 0.02685335946277943 5.6452380658552225e-08 7.24831773868017 -0.07102109641080545 ELQQAELPNRS(ph)PGFGIK ddPTM_A459_Selumetinib_30min_R1 2 ELQQAELPNRSPGFGIK 17 1 F8VU11;Q6NWY9-2;Q6NWY9-3;Q6NWY9 F8VU11 PRPF40B Pre-mRNA-processing factor 40 homolog B 1 ELQQAELPNRS(1)PGFGIK;ELQQAELPNRS(1)PGFGIK 64.52199999999999 0.025044 77944000.0 4143.0 5541.700000000001 4922.9 4872.4 4304.5 4335.3 4525.7 3685.8 2163.02 3774.8 True False 4239.523839125329 4892.875187733567 4254.397219554062 4021.5268062756018 3915.158735021199 4291.690818137456 4184.322805338025 3588.040610834288 3670.4869592697623 4259.332349665705 0.995349386027148 1.1487422877713653 0.9988413371612032 0.9441683522515524 0.9191954075451476 1.007597075272675 0.9823893657104342 0.8423950789179193 0.86175171551425 1.0 12.056411590391503 -5.554600309662737 3.67908838576806 0.9347790074084139 1.073693533307149 0.43184210376016663 0.0617622357684163 0.20121265147840145 5.790127043181278 0.017701146440983827 0.03472185806393197 2.78868647475584e-06 5.554600309662737 0.138914525898735 ELQQAELPNRS(ph)PGFGIK ddPTM_A459_Selumetinib_30min_R2 2 ELQQAELPNRSPGFGIK 17 1 F8VU11;Q6NWY9-2;Q6NWY9-3;Q6NWY9 F8VU11 PRPF40B Pre-mRNA-processing factor 40 homolog B 1 ELQQAELPNRS(1)PGFGIK;ELQQAELPNRS(1)PGFGIK 143.67 0.0014673 2773200.0 27378.1 24577.6 32836.8 30978.2 29899.9 24011.6 24675.5 21974.8 18578.7 30333.9 True False 25856.534805217903 26462.622890560215 30724.116038004624 26758.91571962431 26143.607253502527 27318.979944397328 25822.95964357567 22038.74302987603 22294.95913225054 29458.08149006273 0.8777399442641993 0.8983145388978236 1.0429774949318737 0.9083726558584969 0.8874850611816559 0.9273848995771501 0.876600183629972 0.7481391154855244 0.7568367661611444 1.0 14.846375854902838 -7.535498866124745 5.917063303696732 0.8132285310052646 0.924039128773138 0.19301170960689373 0.07802651393020536 0.20538787070694284 26.47376554925428 0.035690054143179495 0.021153092531951752 2.9140777429640212e-08 7.535498866124745 0.11081059776787339 ELRAPS(ph)PPVEHPR ddPTM_A459_Selumetinib_30min_R1 3 ELRAPSPPVEHPR 13 1 Q86WR7;Q86WR7-2 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 ELRAPS(1)PPVEHPR;ELRAPS(1)PPVEHPR;ELRAPS(1)PPVEHPR 92.8 0.0098811 68075000.0 5761.7 5938.1 12699.400000000001 12954.7 10219.2 7535.9 7062.299999999999 6472.4 4080.47 4465.7 True False 5895.9363996834145 5242.864491452203 10974.891232810915 10692.404834836736 9294.875164346295 7460.095688049741 6529.585025109646 6300.730926681825 6924.25956426269 5038.916094601606 1.170080288893869 1.0404746562597251 2.178026191896459 2.121965246909338 1.844617967404591 1.480496112257563 1.29583126659026 1.2504139399010934 1.374156551580791 1.0 12.298897718165627 -7.093213459232863 3.058267695797329 1.2487820758426091 1.688048624645925 0.25749219183505534 0.34997481428647503 0.4390230148094581 7.899172418331915 0.1623612571052028 0.12404461047299836 8.068383652252163e-08 7.093213459232863 0.43926654880331584 ELRAPS(ph)PPVEHPR ddPTM_A459_Selumetinib_30min_R2 3 ELRAPSPPVEHPR 13 1 Q86WR7;Q86WR7-2 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 ELRAPS(1)PPVEHPR;ELRAPS(1)PPVEHPR;ELRAPS(1)PPVEHPR 84.62 0.012373 29969600.0 60377.0 106333.0 90802.0 105848.0 92590.0 55371.2 38142.9 32501.199999999997 16812.4 86853.0 True False 57021.48804828099 114488.39918551616 84959.89817774257 91431.31980201532 80958.01643489767 62998.08019029191 39916.620428722505 32595.77311113667 20175.349777705072 84345.32821880515 0.6760479715054071 1.357376888599154 1.0072863544658113 1.0840116664769859 0.9598399596582248 0.7469065746814679 0.4732522982799055 0.38645617723578085 0.2391993748055259 1.0 16.36402054121917 -6.943673539346807 2.0342654295795004 0.47053729501979025 1.0503250733108374 0.4758492480096139 0.24118794795116605 0.24528676891343312 2.058566999410653 0.0987521603964441 0.07993834323487423 1.1384827656534981e-07 6.943673539346807 0.5797877782910471 ELRTGKEKVTSGS(ph)T(ph)T(ph)T(ph)TR ddPTM_A459_Selumetinib_30min_R2 1 ELRTGKEKVTSGSTTTTR 18 3 P02671-2;P02671 P02671-2 FGA Fibrinogen alpha chain;Fibrinopeptide A;Fibrinogen alpha chain 4 ELRTGKEKVT(0.181)S(0.219)GS(0.847)T(0.875)T(0.852)T(0.551)T(0.474)R 67.668 0.012977 5852100.0 33700.0 17664.0 22156.0 22670.0 22021.0 21544.0 44803.0 38355.0 25853.0 20835.0 True False 31827.08891178877 19018.772001287973 20730.507081628843 19582.306892068707 19254.525109762206 24511.490443039875 46886.428275460305 38466.606699987926 31024.32239317462 20233.43941416886 1.5729944998625014 0.9399673289341853 1.0245666422443187 0.9678189897045292 0.9516189865514831 1.2114346919127958 2.3172742565273983 1.9011402813231513 1.5333192621442915 1.0 14.304453959159044 -7.03616373719105 16.625848773160506 1.7632351069229966 1.073313198005344 0.3845295642300328 0.3545622106023371 9.999950431524907 4596.592223403771 0.1307378278840687 0.10152075117505968 9.201026103557015e-08 7.03616373719105 -0.6899219089176525 ELS(ph)APAR ddPTM_A459_Selumetinib_30min_R1 2 ELSAPAR 7 0 F5H672;F5H5N2;B4DNC9;B3KQ30;Q9H1K1 F5H672 ISCU Iron-sulfur cluster assembly enzyme ISCU, mitochondrial 1 ELS(1)APAR;ELS(1)APAR 101.25 0.020043 89220000.0 9175.7 11062.3 11591.3 11583.099999999999 10042.1 9542.4 10220.4 8653.4 4797.0 7784.9 True False 9389.475957195811 9767.120773276252 10017.26512645331 9560.329026715965 9133.793828076756 9446.412119805973 9449.466999508752 8423.883721795386 8140.158640982081 8784.167746347495 1.0689089995008356 1.1119005300573266 1.1403772577793205 1.0883591141222457 1.0398018448446225 1.0753906792972894 1.075738450399913 0.9589848423942134 0.9266852450952799 1.0 13.100689889610038 -7.7457225054404 4.951133863360332 0.9555333542631743 1.0876609980619916 0.7819346800625797 0.029977789999821713 0.08397270803930595 5.423715347688705 0.016890317746343066 0.00879324563437664 1.795880747003262e-08 7.7457225054404 0.13212764379881725 ELS(ph)DLEEENR ddPTM_A459_Selumetinib_30min_R2 2 ELSDLEEENR 10 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 ELS(1)DLEEENR;ELS(1)DLEEENR 120.86 0.0049583 13335100.0 50552.0 55723.0 68411.0 66253.0 66974.0 36617.0 47001.0 47825.0 39336.0 64548.0 True False 47742.522215689765 59996.77492231493 64009.510740265 57229.22710720016 58560.12736484324 41660.6593739691 49186.63963071463 47964.16283214504 47204.29913967108 62684.33152415511 0.7616340647629369 0.9571255441911422 1.0211405176363608 0.9129749925648828 0.9342067776901692 0.6646104115813274 0.7846719975271778 0.7651698864119222 0.7530478189989331 1.0 15.93581725387982 -6.730444168998719 24.98382472941452 0.7782713620938957 0.9251382446376161 0.2694371529182952 0.10006732312135533 225.3146169870497 181615.27125766117 0.03184520604935945 0.031842057977910364 1.8601836849399314e-07 6.730444168998719 0.14686688254372038 ELS(ph)DSCEGAFGGGR ddPTM_A459_Selumetinib_30min_R2 2 ELSDSCEGAFGGGR 14 0 H0Y7R3;F8W9F9;H0Y7T5;Q9Y3S1-2;Q9Y3S1-4;Q9Y3S1 H0Y7R3 WNK2 Serine/threonine-protein kinase WNK2 1 ELS(0.68)DS(0.32)CEGAFGGGR;ELS(0.999)DS(0.001)CEGAFGGGR 141.59 0.00055309 4871900.0 16131.900000000001 10964.8 14621.3 19132.0 20258.8 15524.1 15653.8 17572.6 17262.8 17063.9 True False 15235.35357911232 11805.764902611103 13680.581476467769 16526.18859545914 17713.708428030084 17662.403861251158 16381.732717416253 17623.733356699457 20715.842362932523 16571.220869663364 0.9193863082836224 0.7124257769217055 0.8255626778539029 0.9972825011169417 1.0689440788553033 1.0658480748141739 0.9885652268026912 1.063514480635697 1.2501096042269668 1.0 14.016392275272644 -5.849060638053128 2.919827092937545 1.0699807900022167 0.8034869092212921 0.6605938742152825 0.08120082264381417 0.15069024477815374 2.588338564075982 0.02389539149825533 0.03940816559969222 1.4155961145736532e-06 5.849060638053128 -0.2664938807809246 ELS(ph)LDDPEVEQVSGR ddPTM_A459_Selumetinib_30min_R2 1 ELSLDDPEVEQVSGR 15 0 L7N2F4;C9J5N1;Q9BTE6;Q9BTE6-2;Q9BTE6-3 L7N2F4 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 1 ELS(1)LDDPEVEQVSGR 118.21 0.0024437 0.0 5114.3 3174.0 4020.5 3872.8 4749.3 3578.0 2911.9 4245.2 3487.6 4141.7 True False 4830.0676801650225 3417.4355939814354 3761.8254071894207 3345.3179590473605 4152.650474719298 4070.837022149862 3047.3091198203874 4257.552829169309 4185.2174516859095 4022.118359571063 1.200876565124285 0.8496606236982758 0.9352846114629503 0.8317303619588461 1.0324535738332064 1.0121126874505988 0.7576378533388973 1.0585349431694382 1.0405505451441364 1.0 11.973739821365955 ELS(ph)PAALEK ddPTM_A459_Selumetinib_30min_R1 3 ELSPAALEK 9 0 O75683 O75683 SURF6 Surfeit locus protein 6 1 ELS(1)PAALEK;ELS(1)PAALEK;ELS(1)PAALEK 158.56 0.00087615 393517000.0 24718.4 25243.7 27854.4 26507.0 24135.0 20715.6 24864.5 22831.1 13375.6 19346.0 True False 25294.290626366277 22288.15586852227 24071.925473267118 21878.050048014804 21951.993511380348 20507.21987225987 22988.950746476203 22225.54506213543 22697.416284828003 21829.247545997845 1.1587339679513466 1.0210226358722365 1.1027372987797026 1.0022356474685683 1.005623004875631 0.9394377808510237 1.0531261188932266 1.0181544286078812 1.0397708962253867 1.0 14.41397478104779 -1.5228787452818806 0.7756355075470646 1.011118734689012 29.89010066957233 0.5246262624204521 0.03961573207524727 358.88272061734773 1.388467041737191 0.014498538438660561 18164.72390476814 0.02999999999989341 1.5228787452818806 28.878981934883317 ELS(ph)PAALEK ddPTM_A459_Selumetinib_30min_R2 5 ELSPAALEK 9 0 O75683 O75683 SURF6 Surfeit locus protein 6 1 ELS(1)PAALEK;ELS(1)PAALEK;ELS(1)PAALEK;ELS(1)PAALEK;ELS(1)PAALEK 150.46 0.0013177 439162900.0 453160.0 373559.0 421827.0 453545.0 435152.0 355411.0 393422.0 383214.0 330966.0 389128.0 True False 427975.18134321 402209.77411849826 394687.11007051234 391771.3885912358 380484.3154517617 404365.6391501689 411716.9025509038 384329.089295507 397168.44796268933 377892.86356403725 1.1325304672515624 1.0643486895336416 1.0444418196948277 1.0367260839389911 1.0068576364826887 1.0700536531345362 1.0895069535525503 1.017031879540586 1.0510080667225559 1.0 18.52761774826626 -4.708121945083415 2.0890538699445322 1.0415976140362235 1.170038238914787 0.5370489818158979 0.026016699356692412 0.7329842305508008 3.0488100121150645 0.007037077832560275 0.19228918171065876 1.9582947288164627e-05 4.708121945083415 0.12844062487856345 ELS(ph)PAALEKR ddPTM_A459_Selumetinib_30min_R1 1 ELSPAALEKR 10 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 ELS(1)PAALEKR 67.252 0.042805 8531400.0 1546.9 1657.3 3335.4 3108.5 2926.2 2042.4 1719.7 2235.3 1499.2 1849.6 True False 1582.9397602565696 1463.2625455421335 2882.4710000407536 2565.6588287717955 2661.5257266625686 2021.8553103508254 1589.9816444615863 2176.01258272231 2544.0329027642974 2087.014176629672 0.7584710147071764 0.701127266852189 1.381145864900481 1.2293442265519676 1.275279179445095 0.9687789057647553 0.7618451576736552 1.042643891493043 1.2189820899408872 1.0 11.027224685104185 -5.233470759214148 24.843582705567652 1.1039981987071932 0.7297989758982294 0.44593894981168203 0.16930979365983156 690.1207681152823 613008.5577748975 0.04780642928879003 0.1264281527008237 5.841565366765214e-06 5.233470759214148 -0.3741992228089638 ELS(ph)PAALEKR ddPTM_A459_Selumetinib_30min_R2 1 ELSPAALEKR 10 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 ELS(1)PAALEKR 80.318 0.024576 8102700.0 32461.0 41269.0 38807.0 54698.0 43103.0 32579.0 24756.0 22874.0 16308.0 47527.0 True False 30656.947571678786 44434.19959925009 36310.19986986689 47248.03804068699 37688.0157942909 37066.461527283514 25907.20305308337 22940.55955300546 19570.055683591516 46154.77202002415 0.6642205395008415 0.9627216787025273 0.7867052155325084 1.023686955277095 0.816557295049362 0.803090556079495 0.5613114726651359 0.49703548623428895 0.42400936733261485 1.0 15.494192197815037 -7.165727771966455 3.4973002334686236 0.5776470220357199 0.8595587760885468 0.27705644237528815 0.17096766898387808 0.26244804303377967 6.030799720468346 0.066615154549933 0.04965239225714803 6.827665373633455e-08 7.165727771966455 0.28191175405282687 ELS(ph)PAGSISK ddPTM_A459_Selumetinib_30min_R1 5 ELSPAGSISK 10 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 ELS(0.999)PAGS(0.001)ISK;ELS(1)PAGSISK;ELS(0.997)PAGS(0.003)ISK;ELS(1)PAGSISK;ELS(1)PAGSISK 124.39 0.0038579 858545300.0 25764.999999999996 29017.699999999997 31557.9 33451.8 29454.5 25532.100000000002 28555.9 27712.0 14931.7 23520.300000000003 True False 26365.274370037183 25620.294194037255 27272.510515136433 27610.07109805642 26790.34567561435 25275.27025529197 26401.905472513023 26976.987738737807 25338.004331780718 26539.359612123102 0.993440488217116 0.9653697213678804 1.0276250412115608 1.0403442849255573 1.0094571258372262 0.952369259269779 0.9948207439207655 1.0164897771841788 0.9547330720145332 1.0 14.6958459388197 ELS(ph)PAGSISK ddPTM_A459_Selumetinib_30min_R2 4 ELSPAGSISK 10 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 ELS(1)PAGSISK;ELS(1)PAGSISK;ELS(1)PAGSISK;ELS(1)PAGSISK 176.32 6.6876e-05 810170000.0 1622740.0 1475520.0 1735800.0 1768370.0 1783490.0 1205240.0 1297930.0 1418460.0 1179920.0 1393470.0 True False 1532554.60714291 1588687.6394554162 1624120.5177961446 1527514.955391598 1559432.041597103 1371250.869920598 1358286.3167995044 1422587.4837613048 1415936.9697193627 1353236.9004301364 1.1325102106333165 1.1739907764490016 1.2001745720057633 1.12878606466175 1.152371799129499 1.0133117634353126 1.0037313617207475 1.051247925111357 1.0463334019854889 1.0 20.367982991904015 -6.75155139050508 12.293269627648368 1.0249195348830729 1.1592744261935812 0.8840575951144544 0.024370575002623174 0.1580345341722121 193.62899831928036 0.008585294503223895 0.008323288023367915 1.7719383574719606e-07 6.75155139050508 0.13435489131050837 ELS(ph)PEGPGK ddPTM_A459_Selumetinib_30min_R2 1 ELSPEGPGK 9 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 ELS(1)PEGPGK 81.771 0.04303 15396000.0 155800.0 82297.0 128390.0 151940.0 133570.0 105720.0 214310.0 171500.0 171670.0 132840.0 True False 147141.2597168157 88608.91527343725 120129.52718046239 131245.50988888048 116789.74246904932 120281.97036939154 224275.83964720895 171999.03660664646 206008.79686056837 129004.56404022986 1.1405895660476781 0.6868665146281546 0.9312036986768949 1.0173710586545743 0.9053148106653702 0.9323853870153137 1.7385108915779826 1.3332786935585383 1.5969109185650585 1.0 16.977062581959203 -7.237342856587404 23.750095037352157 1.4449483059750783 0.9264521231567199 0.5615449641622258 0.2077853914341133 266.61414131421304 262781.25454517105 0.07386989457517174 0.057180238664629846 5.7897144320971414e-08 7.237342856587404 -0.5184961828183584 ELS(ph)PPPGLPSK ddPTM_A459_Selumetinib_30min_R1 1 ELSPPPGLPSK 11 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 ELS(1)PPPGLPSK 85.973 0.034119 5103600.0 4498.0 4620.9 4242.8 4491.3 3748.9 4121.1 3804.1 3856.9 2313.1 3445.7 True False 4602.794648415572 4079.88287980187 3666.6510640321694 3706.978767142601 3409.812656922053 4079.6454756594144 3517.1536743015195 3754.6024830231627 3925.161757860258 3887.989158960241 1.1838496611565887 1.049355518494539 0.9430713189058213 0.9534436994505284 0.8770118736220792 1.0492944575880525 0.9046202369664288 0.9656926317220622 1.009560880285468 1.0 11.92480848088559 -4.872553521930919 2.3639628999805664 0.9592787235857058 1.2137483511125817 0.6715264617011225 0.04766117534450965 0.25376745086807323 2.0416080007943895 0.012151480049118743 0.12468243452010831 1.3410546552542904e-05 4.872553521930919 0.25446962752687596 ELS(ph)PPPGLPSK ddPTM_A459_Selumetinib_30min_R2 2 ELSPPPGLPSK 11 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 ELS(1)PPPGLPSK;ELS(1)PPPGLPSK 105.66 0.011568 18133200.0 201546.0 181742.0 193451.0 224450.0 233740.0 177687.0 186116.0 171777.0 156140.0 205150.0 True False 190344.88017256287 195681.02700736377 181004.57327352325 193879.5228021536 204375.49153788743 202161.77136801102 194770.76278185757 172276.8426307868 187372.36291611328 199226.78645628743 0.9554181119832832 0.9822023960131403 0.9085353254605533 0.9731599161475856 1.0258434378889592 1.0147318790004554 0.9776334108796783 0.8647273074827528 0.940497842930498 1.0 17.604052108236395 -10.539640337640714 4.4376620012618115 1.000001109312006 0.9610318405446308 0.06467755932028707 0.045209222784223145 367647272437.8785 81481457023.05487 6653453.027941283 0.012024464369968301 2.8864209122691736e-11 10.539640337640714 -0.038969268767375276 ELSDIAHR ddPTM_A459_Selumetinib_30min_R1 4 ELSDIAHR 8 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;;; 171.53 0.00022430000000000006 289370000.0 49893.0 60611.0 61351.0 62846.0 64419.0 52896.0 61118.0 53821.0 25680.9 42413.4 False True 51055.409825121846 53514.63594271056 53019.87117692034 51871.12586552755 58592.312824098175 52363.91426572529 56507.82005361587 52393.49224475349 43578.61164127511 47857.573031501386 1.066819869689496 1.1182062221894435 1.1078679468768915 1.0838645292644555 1.2243059794430202 1.0941615077567282 1.1807498056038197 1.0947795495243025 0.9105896701571196 1.0 15.54645961587013 -8.155362594192107 5.1430199466857065 0.9572172564790332 1.1258401966559437 0.6539062576591044 0.04860378066212193 0.12427306652928727 4.774724599834366 0.033707569587911664 0.0120943864177407 6.992579389830461e-09 8.155362594192107 0.16862294017691049 ELSDIAHR ddPTM_A459_Selumetinib_30min_R2 6 ELSDIAHR 8 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;;;;; 145.16 0.0028552 212147900.0 699966.0 662920.0 808246.0 846297.0 907092.0 633190.0 646264.0 669308.0 644007.0 763591.0 False True 661064.691905908 713763.8323762366 756244.3323117074 731029.8886562438 793134.9934546306 720406.1749734696 676316.5565478216 671255.5754700953 772826.395059034 741544.1437823176 0.891470450476601 0.9625372115213736 1.0198237537881563 0.9858211338944101 1.0695721894709718 0.971494658833078 0.9120381601265214 0.905213237941967 1.0421852853117526 1.0 19.500173052646318 -4.8062764541773415 3.630771336489033 0.9847301914542178 0.8835759630819122 0.26049282557658127 0.04878092073610276 0.3933451058671378 8.848854702527754 0.013227710296579504 0.10372728029772732 1.56215292315488e-05 4.8062764541773415 -0.10115422837230559 ELSDQATAS(ph)PIVAR ddPTM_A459_Selumetinib_30min_R2 2 ELSDQATASPIVAR 14 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 ELSDQAT(0.084)AS(0.916)PIVAR;ELSDQAT(0.003)AS(0.997)PIVAR 208.38 6.030499999999998e-06 64484000.0 65802.0 50736.0 64364.0 69890.0 57290.0 39581.0 50729.0 54370.0 50258.0 38890.0 True False 62144.98826627662 54627.28805804725 60222.890314224525 60370.8614330253 50092.7180209017 45032.92346945606 53087.99901760648 54528.207698561935 60311.00432584883 37767.14465164513 1.6454775397898551 1.4464235663541933 1.5945841516404187 1.5985021369730568 1.3263570355382868 1.1923835885616634 1.4056662082155573 1.4438001125453548 1.5969172380422911 1.0 15.204844093890703 -6.26369977760157 24.805699882185788 1.3468611166715336 1.5639978549071647 0.3661321468500588 0.15574606154580978 228.31959929984188 2505584.1136308573 0.047253790411091054 0.05620926016732932 5.448791909180173e-07 6.26369977760157 0.21713673823563107 ELSEQIQR ddPTM_A459_Selumetinib_30min_R2 1 ELSEQIQR 8 0 P15311;E7EQR4 P15311 EZR Ezrin 0 136.27 0.036085 3376300.0 22150.0 18920.0 23647.0 21063.0 22969.0 19132.0 18567.0 18210.0 17634.0 27151.0 False True 20918.9916734754 20371.103162611456 22125.577764906895 18194.18306429834 20083.42887453468 21767.259336995863 19430.402289812526 18262.98808517222 21161.292735127106 26367.080083230067 0.7933753607696687 0.7725960970387404 0.8391364419217264 0.6900340502955489 0.761685738850852 0.8255468284044174 0.7369190000742861 0.6926435550513538 0.8025648903226894 1.0 14.686450194108534 -8.554738391444458 22.352604553615787 1.0000000011009778 0.7642793055365157 0.6961238897654809 0.04655362668562432 1698.1199982121914 1191392.7976249326 0.04559460387687287 0.011772476097832526 2.7877999666269476e-09 8.554738391444458 -0.23572069556446207 ELSESVQQQSTPVPLIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ELSESVQQQSTPVPLISPK 19 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 ELSESVQQQSTPVPLIS(1)PK;ELSESVQQQSTPVPLIS(1)PK 156.7 2.0531e-06 11972800.0 4273.0 5424.6 5758.8 4964.2 4393.2 4813.9 4878.0 4343.7 3085.6 4703.5 True False 4372.552586189362 4789.485310171879 4976.786590824096 4097.295659575022 3995.8358356824583 4765.476536671484 4510.048532699671 4228.49096567391 5236.037836692582 5307.240040969756 0.823884458293768 0.902443694500151 0.9377353487698517 0.7720200382770611 0.752902790308374 0.8979199169217755 0.8497916992417741 0.7967401008870265 0.9865839487704491 1.0 12.37374608648963 -8.275311611105852 23.555525961989048 0.9932921007396665 0.8437709235244015 0.5396580135053552 0.05598459100390586 344.2962416687622 584614.5598645529 0.056065009853376264 0.014835122060347412 5.3050366537911874e-09 8.275311611105852 -0.14952117721526492 ELSESVQQQSTPVPLIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ELSESVQQQSTPVPLISPK 19 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 ELSESVQQQSTPVPLIS(1)PK;ELSESVQQQSTPVPLIS(1)PK 158.8 1.5509e-06 20753800.0 111769.0 99761.0 107586.0 100509.0 96513.0 81587.0 105548.0 102201.0 70723.0 102072.0 True False 105557.32642675731 107412.34791782683 100664.03389077977 86819.50081230408 84388.17410283278 92824.86867695379 110456.19113939424 102498.38798971353 84869.57616572517 99124.91614509464 1.0648919618983304 1.0836059398083264 1.0155270521836532 0.8758595133157192 0.8513316064682378 0.9364433513475147 1.1143130852964696 1.0340325316359507 0.8561881257129829 1.0 16.596960119916055 -5.525360691805737 24.490149853627198 0.9550773676031866 1.0680783590537692 0.28279601939440224 0.0781179836062688 81.92668678542525 808394.1587882465 0.02346980634279042 0.04099116574953189 2.982904217600209e-06 5.525360691805737 0.11300099145058262 ELSESVQQQSTPVPLIS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 2 ELSESVQQQSTPVPLISPKR 20 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 ELSESVQQQSTPVPLIS(1)PKR;ELSESVQQQSTPVPLIS(1)PKR 165.0 2.7837e-08 79914000.0 2613.8 2971.7 5284.9 5872.9 3920.8 3333.3 3053.8999999999996 2569.1000000000004 1975.74 2010.2599999999998 True False 2674.6964544305533 2623.7719824941487 4567.2396078777265 4847.308262986612 3566.1643322734635 3299.7700283942463 2823.541864291004 2500.9591223870993 3352.6864776597736 2268.296452590596 1.179165294455146 1.1567147581161925 2.013510889487806 2.136981811813247 1.5721773616497912 1.4547349067295043 1.2447852048026036 1.1025715441783555 1.478063625162711 1.0 11.147393488757398 -7.055306201290346 2.4435438468922 1.2119358272699905 1.6362790675488337 0.27434814522597983 0.3103491719830052 0.4541005458318224 5.370467986959959 0.14794509135300177 0.11330100050868577 8.804279044460099e-08 7.055306201290346 0.4243432402788432 ELSESVQQQSTPVPLIS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 3 ELSESVQQQSTPVPLISPKR 20 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 ELSESVQQQSTPVPLIS(1)PKR;ELSESVQQQSTPVPLIS(1)PKR;ELSESVQQQSTPVPLIS(1)PKR 193.96 8.547000000000001e-16 34775900.0 67765.0 93849.0 88531.0 97679.0 86174.0 46615.9 31049.4 36751.6 25829.3 82970.0 True False 63998.8925847882 101046.916527903 82835.01184526482 84374.95169432633 75348.05171466546 53036.81708799213 32493.258623218902 36858.54107144511 30995.8817309413 80574.44051805083 0.7942828044887352 1.2540815161510899 1.028055687544086 1.0471677017158323 0.9351358970688165 0.6582337618107378 0.4032700495877417 0.45744706180352335 0.38468627931704213 1.0 16.29803464527751 -6.779185843323324 2.5108456812682105 0.5157608446724525 1.0434956929898713 0.5536501809094916 0.19418043424571477 0.18394192206689738 2.3770197112431433 0.07009179081173163 0.06418124723699566 1.6627009949958404e-07 6.779185843323324 0.5277348483174188 ELSFGR ddPTM_A459_Selumetinib_30min_R2 1 ELSFGR 6 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 167.23 0.00052075 10694000.0 26545.0 22393.0 24045.0 28828.0 29813.0 21143.0 22763.0 22176.0 20363.0 22268.0 False True 25069.735168054376 24110.47109515635 22497.970878216543 24901.5766689262 26067.624408398362 24055.256332955432 23821.524604028804 22240.528488565575 24436.16898975805 21625.06498078772 1.1592906282745044 1.1149317292954601 1.0403654693386741 1.1515145360742 1.205435656797218 1.1123784531665806 1.1015700819947813 1.0284606547228714 1.1299928583552368 1.0 14.400416847434967 -8.727994742322217 0.5465349028689604 1.0000928569615946 1.1293736059881259 0.36005623005586884 0.04868961318231375 1.4441877179400013 0.9437937958575329 0.0618179269772525 0.025306882391776808 1.870704787449459e-09 8.727994742322217 0.1292807490265313 ELSKEDLSPAFDHS(ph)PNK ddPTM_A459_Selumetinib_30min_R1 2 ELSKEDLSPAFDHSPNK 17 1 K7EIY0;K7ENP9;K7EIE9;D3DUJ3;K7EQG9;P17706-2;P17706-4;P17706;P17706-3 K7EIY0 PTPN2 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 2 1 ELSKEDLSPAFDHS(1)PNK;ELSKEDLSPAFDHS(1)PNK 130.25 0.00048162 59358000.0 9650.8 10284.8 9928.6 10184.2 8901.6 9687.6 8847.7 9141.3 5750.7 8674.9 True False 9875.644862812143 9080.650834726193 8580.350653895966 8405.720651110736 8096.451851705122 9590.151539637027 8180.310865675864 8898.843028872834 9758.517885490024 9788.407915681622 1.0089122713195025 0.9276943618357425 0.8765828649365669 0.8587423739916134 0.8271469601030945 0.9797457995465252 0.8357141361641162 0.9091205746152393 0.9969463849025221 1.0 13.256858509257615 -8.247500799502147 5.023111786064491 1.0003809207280316 0.8988000823759443 0.32108669768528075 0.0554534000565496 0.20319221569729168 15.665710676365368 0.04520525183060071 0.014407820735107293 5.6558671588732295e-09 8.247500799502147 -0.10158083835208731 ELSKEDLSPAFDHS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 1 ELSKEDLSPAFDHSPNK 17 1 K7EIY0;K7ENP9;K7EIE9;D3DUJ3;K7EQG9;P17706-2;P17706-4;P17706;P17706-3 K7EIY0 PTPN2 Protein-tyrosine-phosphatase;Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 2 1 ELS(0.001)KEDLS(0.003)PAFDHS(0.996)PNK 49.188 0.046716 17316000.0 83355.0 80548.0 83418.0 87080.0 84797.0 78459.0 81235.0 69050.0 51557.0 84669.0 True False 78722.46279650304 86725.77259735888 78050.97669865115 75219.55377862114 74144.04276520172 89266.01507011062 85012.58846409875 69250.92406815712 61869.840622941374 82224.38597351867 0.9574101632313379 1.0547451534060703 0.9492436553285832 0.9148083368217121 0.9017281416863445 1.0856391812869213 1.0339096784678703 0.8422188046555945 0.7524512331763388 1.0 16.327278709046524 -7.7729359037624235 24.973503724695732 0.8480011958189358 0.9845622065625463 0.3178539643780548 0.07972199879583616 241.97932963171857 525635.1146346852 0.0435298712335457 0.02119417329562008 1.6868019571286164e-08 7.7729359037624235 0.1365610107436105 ELSNS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 3 ELSNSPLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ELS(0.001)NS(0.999)PLR;ELS(0.001)NS(0.999)PLR;ELS(0.002)NS(0.998)PLR 141.91 0.0022482 1010610000.0 18207.0 25583.9 14658.4 14750.6 17744.0 15007.3 21020.199999999997 19368.2 9825.900000000001 18843.399999999998 True False 18631.187675345125 22588.525094367567 12667.869792827649 12174.684613054938 16139.058332957635 14856.340187538173 19434.629390539878 18854.492419219885 16673.834644658287 21262.133940259268 0.8762614198411892 1.0623827861227426 0.5957948448834378 0.5725993753619671 0.7590516727203365 0.6987229141383641 0.9140488647633312 0.8867638813769027 0.7842032550216814 1.0 14.375998777478381 -10.675114670387345 7.630697084925278 1.0000000705286516 0.7923191582957924 0.15927767699873518 0.1416156886367042 1.8443934691829948e-07 2.0642005865106607e-08 0.14888039288186228 0.03610878730592734 2.112931071397471e-11 10.675114670387345 -0.20768091223285923 ELSNS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 3 ELSNSPLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ELS(0.002)NS(0.998)PLR;ELS(0.002)NS(0.998)PLR;ELS(0.001)NS(0.999)PLR 117.14 0.0090084 1255100000.0 438634.0 335200.0 417650.0 454246.0 491282.0 365730.0 486697.0 471445.0 407511.0 390033.0 True False 414256.4782710252 360908.76216212317 390778.85370293865 392376.91118194273 429562.7630431948 416105.9877336138 509329.3748718094 472816.8268980792 489024.5868086874 378771.7338625647 1.0936837182822514 0.9528397446179998 1.0317001475213845 1.0359191990929149 1.1340940324735511 1.0985666313859515 1.3446868637156986 1.2482896283639746 1.2910799383623683 1.0 18.530969147012215 -6.715200759469893 1.5472008269385267 1.2363161547313457 1.0232559403504247 0.4081027377020058 0.09568268854658613 0.3217064192175528 1.599881966553934 0.03957617710573142 0.037308791791994145 1.9266340903312265e-07 6.715200759469893 -0.21306021438092104 ELSNS(ph)PLRENS(ph)FGSPLEFR ddPTM_A459_Selumetinib_30min_R1 2 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 ELS(0.072)NS(0.928)PLRENS(0.828)FGS(0.172)PLEFR;ELS(0.053)NS(0.947)PLRENS(0.716)FGS(0.284)PLEFR 94.838 0.0035132 56941000.0 8093.200000000001 9485.0 11819.099999999999 11466.3 10654.1 8896.3 9141.7 8907.6 5360.299999999999 6621.9 True False 8281.755813374144 8374.49179054313 10214.131137669148 9463.92595410843 9690.438536134136 8806.81129919411 8452.134208975109 8671.34151203742 9096.037599177871 7471.885367768178 1.1083890351288768 1.1208003573861782 1.3670085440189332 1.26660481100706 1.2969201291465517 1.1786598516599927 1.1311916327618563 1.1605292486744232 1.2173684621040728 1.0 12.86725660632891 -6.981355516537018 10.520559929483486 1.1426643373164715 1.2354986422276142 0.23120852563201566 0.08816596949220942 0.6562116224183554 358.3147687940641 0.03268209102498949 0.028594029107416003 1.043865353801525e-07 6.981355516537018 0.09283430491114264 ELSNS(ph)PLRENS(ph)FGSPLEFR ddPTM_A459_Selumetinib_30min_R2 1 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 ELS(0.089)NS(0.911)PLRENS(0.7)FGS(0.3)PLEFR 65.881 0.045927 8134800.0 50275.0 49008.0 47493.0 56257.0 57684.0 42380.0 35553.0 33537.0 29125.0 57435.0 True False 47480.916766770926 52766.756014443024 44437.3520864686 48594.69955126202 50437.22021849703 48217.46031266381 37206.28494693299 33634.587117650764 34950.81382049319 55776.70231594855 0.851267909275347 0.9460357788014142 0.7967009565167924 0.8712365115455574 0.9042703875319504 0.8644731278578426 0.6670578109149774 0.6030221529972638 0.6266202978891333 1.0 15.767375020027812 -7.253988743214406 21.444167144859833 0.6910935620759368 0.8736454185428721 0.2859295134073331 0.10981970340911412 81.83790445882504 235544.560695235 0.04033821845203659 0.03047142115594698 5.572001912102905e-08 7.253988743214406 0.1825518564669354 ELSNS(ph)PLRENSFGS(ph)PLEFR ddPTM_A459_Selumetinib_30min_R1 3 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 ELS(0.007)NS(0.988)PLRENS(0.134)FGS(0.871)PLEFR;ELS(0.046)NS(0.937)PLRENS(0.34)FGS(0.678)PLEFR;ELS(0.055)NS(0.943)PLRENS(0.126)FGS(0.876)PLEFR 74.819 0.019051 65738000.0 5691.0 6176.099999999999 7452.0 8005.200000000001 7294.9 6420.4 6047.299999999999 5765.27 3423.9300000000003 4990.9 True False 5823.589227241671 5452.999340809009 6440.059330905948 6607.242096214887 6635.077583019199 6355.8166052567785 5591.147292290836 5612.356311363774 5810.159136047063 5631.530630482824 1.0341041555770392 0.9682979102151295 1.143571748690605 1.173258662653924 1.178201455054562 1.1286126316801828 0.992829065339111 0.996595185149973 1.031719352567727 1.0 12.459311379771282 -7.2648905890121025 24.91502375241782 1.0050021615083229 1.106430431378087 0.390213566424667 0.060628373608287024 354.8797198826796 2561931.277327997 0.028536443158423495 0.020105247614367754 5.433872087624551e-08 7.2648905890121025 0.10142826986976416 ELSNS(ph)PLRENSFGS(ph)PLEFR ddPTM_A459_Selumetinib_30min_R2 2 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 ELS(0.008)NS(0.989)PLRENS(0.006)FGS(0.996)PLEFR;ELS(0.095)NS(0.904)PLRENS(0.073)FGS(0.928)PLEFR 114.53 0.01126 3557800.0 19144.1 19896.3 22239.3 25619.3 29001.5 18230.9 18161.0 17703.3 14408.9 23680.9 True False 18080.147561904305 21422.282233312166 20808.447650319024 22129.90714424243 25358.07229330041 20742.04099136722 19005.522485338784 17754.813672060904 17291.082618304023 22997.170886632666 0.7861900775113851 0.9315181566861375 0.9048264133400052 0.9622882420335301 1.1026605149957833 0.901938812109438 0.8264287193859108 0.7720433856662371 0.7518786855801743 1.0 14.48916877120297 -7.184109404693788 4.231030868546029 0.8181874500647546 0.9416901344465206 0.17949063419093525 0.09598572789454912 0.3265510900229146 11.018712268184055 0.038994020971356735 0.029361702873359243 6.544712830708492e-08 7.184109404693788 0.12350268438176604 ELSNS(ph)PLRENSFGSPLEFR ddPTM_A459_Selumetinib_30min_R1 2 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ELS(0.001)NS(0.595)PLRENS(0.358)FGS(0.045)PLEFR;ELS(0.066)NS(0.922)PLRENS(0.004)FGS(0.007)PLEFR 99.011 0.0017096 748452000.0 4412.8 4746.8 5980.599999999999 6562.7 5839.0 4653.3 4855.4 4567.299999999999 2661.64 3336.2599999999998 True False 4515.609654185912 4191.042449272551 5168.467369084285 5416.647642136292 5310.863480959178 4606.492026858353 4489.153268895033 4446.160367318748 4516.608681505844 3764.501468924366 1.1995239453249997 1.113306100122219 1.3729486923433385 1.438875157002926 1.4107747134115625 1.223665886408744 1.1924960863882257 1.1810754767985663 1.1997893263663353 1.0 11.878243106815075 -7.141352152363033 2.7392524295380882 1.1546322662597828 1.3071408545314558 0.34241119145687027 0.10536840921758467 0.4013103372079851 5.831417707950352 0.050176269560543614 0.03686072317676372 7.22183975458949e-08 7.141352152363033 0.15250858827167302 ELSNS(ph)PLRENSFGSPLEFR ddPTM_A459_Selumetinib_30min_R2 1 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ELS(0.057)NS(0.927)PLRENS(0.016)FGSPLEFR 81.878 0.025954 18747000.0 18423.0 19109.0 20097.0 28537.0 21916.0 12487.0 13602.0 8474.7 9225.5 17958.0 True False 17399.12341311229 20574.59885488067 18803.980899959137 24650.211370929195 19162.716148474123 14206.970904299978 14234.519951851678 8499.359973937893 11070.857782007219 17439.50587951257 0.9976844259992642 1.1797695988079064 1.0782404633407368 1.413469598349547 1.098810727830651 0.8146429722524374 0.8162226642312145 0.4873624306020446 0.6348148771240671 1.0 14.09007154378839 -6.842485826918031 2.4940753934788638 0.6977678627439985 1.1724764445435345 0.6191738792050754 0.15860008811598098 0.17877765015636157 2.2688406874619433 0.06219035528464354 0.05477248947243572 1.4371899548932813e-07 6.842485826918031 0.474708581799536 ELSNSPLRENS(ph)FGS(ph)PLEFR ddPTM_A459_Selumetinib_30min_R1 1 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 ELS(0.003)NS(0.187)PLRENS(0.813)FGS(0.996)PLEFR 108.68 0.025028 7113500.0 1691.3 1901.9 2153.8 2195.3 1920.9 1914.3 2233.8 1605.6 1004.6 1262.0 True False 1730.703999303081 1679.2246638306774 1861.325789976546 1811.9320658847437 1747.1549341624404 1895.043880045333 2065.302667557303 1563.0142722761782 1704.732826919032 1423.9899929209812 1.2153905630705648 1.1792390902875252 1.3071199932792177 1.2724331455223155 1.2269432670510292 1.3307985937163052 1.4503631892249602 1.0976300957494942 1.1971522520479043 1.0 10.475723292473418 -8.487439725211905 1.4199233587927376 1.010116321396574 1.27342348571363 0.46287216730420455 0.08693818328962999 0.3832815350417325 1.6976289545429621 0.08452694275289893 0.025355884642498074 3.2550695676693135e-09 8.487439725211905 0.2633071643170559 ELSNSPLRENS(ph)FGSPLEFR ddPTM_A459_Selumetinib_30min_R1 1 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ELS(0.063)NS(0.191)PLRENS(0.583)FGS(0.162)PLEFR 102.19 0.00061185 819460000.0 3027.7 2792.3 3753.9 3895.6 3679.2 3060.3 2947.4 3173.7 1558.5 2289.9 True False 3098.2395191213486 2465.3762178949482 3244.1409986967014 3215.3065894686843 3346.417009615519 3029.51616053008 2725.075245034645 3089.523166369523 2644.6606716636584 2583.8309705148595 1.1990875388044393 0.9541553785941703 1.2555546534262136 1.2443950963355763 1.295137742291519 1.1724900719517315 1.0546646727791333 1.1957141166064351 1.0235424460202511 1.0 11.335295979316149 -8.313162218300157 5.5120557060977475 1.0057382410717435 1.1696979945520383 0.3113855263420394 0.09495998108930424 0.29036265015670215 19.836541328955526 0.0936153478556897 0.025061375441793547 4.862255560988067e-09 8.313162218300157 0.1639597534802948 ELSNSPLRENSFGS(ph)PLEFR ddPTM_A459_Selumetinib_30min_R2 1 ELSNSPLRENSFGSPLEFR 19 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ELS(0.137)NS(0.338)PLRENS(0.059)FGS(0.466)PLEFR 74.859 0.0052973 256470000.0 17999.0 18250.0 16459.0 22526.0 20971.0 15724.0 10508.0 12583.0 9298.6 17515.0 True False 16998.68763570581 19649.716317001006 15400.045859204243 19457.91994048256 18336.4354968813 17889.838271739634 10996.64282120699 12619.614446772213 11158.579824591861 17009.296440564787 0.9993762937287826 1.155233926674309 0.9053899385560294 1.1439579531389756 1.0780243357480366 1.0517682688553114 0.6465077999923347 0.7419245405516128 0.6560282997937653 1.0 14.054035847258557 -7.249796610401328 24.140544260149756 0.739608877411703 1.0583572253204068 0.6180340239917272 0.11290835416619652 269.7535147826476 559317.6039564067 0.04053860714952736 0.031109192593153537 5.6260474360206274e-08 7.249796610401328 0.31874834790870377 ELSNSVSTYRPFGLGSES(ph)PYK ddPTM_A459_Selumetinib_30min_R1 1 ELSNSVSTYRPFGLGSESPYK 21 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 ELSNS(0.003)VS(0.046)T(0.244)Y(0.153)RPFGLGS(0.242)ES(0.26)PY(0.049)K 63.578 0.0067319 21025000.0 1292.4 2147.1 1232.2 1429.7 1189.2 1723.2 1981.6 1809.6 866.7 2032.4 True False 1322.5104054273652 1895.7165338402895 1064.8740079901106 1180.029733792838 1081.6370699703127 1705.8661725404158 1832.1263166046865 1761.603529590789 1470.7265987365367 2293.2783372524564 0.5766898783912318 0.8266404051553201 0.46434573191229844 0.5145601886278726 0.4716553819045823 0.7438548321108678 0.7989114477921291 0.7681594950664998 0.6413205823496301 1.0 11.163195751401219 -6.895268328522598 6.554132743065745 0.7810658796318128 0.5765770911903831 0.43406596499875094 0.12573367755648035 0.23872430633775882 13.16796004566897 0.045390207789437226 0.040022372027208555 1.272716491107356e-07 6.895268328522598 -0.2044887884414297 ELSNSVSTYRPFGLGSES(ph)PYK ddPTM_A459_Selumetinib_30min_R2 1 ELSNSVSTYRPFGLGSESPYK 21 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 ELS(0.006)NS(0.017)VS(0.017)T(0.063)Y(0.056)RPFGLGS(0.09)ES(0.7)PY(0.05)K 47.175 0.045919 3604600.0 5259.3 7185.2 5306.4 4334.8 6201.6 4470.5 6376.7 6897.5 7482.7 4624.6 True False 4967.009160646012 7736.281735940582 4964.992001171477 3744.3927620529075 5422.499564992566 5086.270795841518 6673.229185191339 6917.570583057404 8979.449084106594 4491.075781846184 1.105973134704973 1.7225898897569623 1.1055239863110204 0.833740721363127 1.2073943590333924 1.1325283836004791 1.4858865691302403 1.5402925532941554 1.9993982556258127 1.0 12.132845350839084 -7.378202952153782 3.8488068584144406 1.568081702089788 1.1906540938707078 0.20227501429565808 0.3065152792942289 0.36442111683838185 9.518034921926708 0.1381400713388081 0.0894258203766174 4.185979024904858e-08 7.378202952153782 -0.37742760821908017 ELSPLISLPS(ph)PVPPLSPIHSNQQTLPR ddPTM_A459_Selumetinib_30min_R1 1 ELSPLISLPSPVPPLSPIHSNQQTLPR 27 0 A0A669KBI3;F5GXF9;P51825;P51825-3;P51825-2;E7ETI4;E7EMC5 A0A669KBI3 AFF1 AF4/FMR2 family member 1 1 ELS(0.001)PLIS(0.017)LPS(0.724)PVPPLS(0.139)PIHS(0.09)NQQT(0.03)LPR 81.65 6.0494e-05 3227800.0 416.26 334.26 461.42 323.28 491.8 444.84 250.67 277.76 165.85 385.59 True False 425.9580480990365 295.12468380674187 398.7616983986341 266.82521671717757 447.3167768343422 440.365313482404 231.76176008442522 270.3929025083653 281.43533679526325 435.0842324646601 0.9790243275102716 0.678316201290318 0.9165160873326378 0.6132725500201862 1.0281153474590135 1.0121380657437933 0.5326825078710481 0.6214725387234714 0.646852530603078 1.0 8.765150924057837 -7.2643908652614195 24.971310951293223 0.6687079462179804 0.8599258128744859 0.18218949602431933 0.1713561520369642 403.8206790462506 3416535.109791703 0.06804001902270368 0.04811401838007197 5.4401282062706176e-08 7.2643908652614195 0.19121786665650553 ELSQCNCIDLSKS(ph)PDPDKSTGTDCR ddPTM_A459_Selumetinib_30min_R2 1 ELSQCNCIDLSKSPDPDKSTGTDCR 25 2 E9PKX1;E9PKY2;A0A0C4DFM7;Q5TAX3 E9PKX1 ZCCHC11 Terminal uridylyltransferase 4 1 ELS(0.006)QCNCIDLS(0.231)KS(0.678)PDPDKS(0.01)T(0.037)GT(0.037)DCR 46.154 0.023853 4076900.0 27343.0 27693.0 32757.0 24006.0 26480.0 26039.0 22815.0 23909.0 17714.0 27721.0 True False 25823.38552270147 29816.96405297034 30649.45028312494 20736.34138734016 23153.34566579642 29625.63589149253 23875.94270706484 23978.571231651986 21257.294970513885 26920.622702192217 0.9592417608006742 1.1075882004223574 1.138511936450455 0.7702771817997933 0.8600598107231369 1.100481077990816 0.8869015762076172 0.890713840348847 0.7896286503351517 1.0 14.71642416093061 -5.747555605831829 24.999997421174392 0.90134759913323 1.0723613994677113 0.3751024461966107 0.0997428757141029 257.1392736113297 463017.3282194177 0.027836228020698888 0.047904439182484826 1.7883165434783183e-06 5.747555605831829 0.17101380033448121 ELSS(ph)PISPK ddPTM_A459_Selumetinib_30min_R2 1 ELSSPISPK 9 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 ELS(0.089)S(0.869)PIS(0.042)PK 91.658 0.026926 7745200.0 41694.0 41604.0 41782.0 43710.0 43874.0 37750.0 38563.0 39809.0 34385.0 41987.0 True False 39376.814394306224 44794.89302205532 39093.79160880199 37756.62259604424 38362.15588146347 42949.71983961913 40356.25591113484 39924.83759926527 41262.96079717284 40774.726214672795 0.9657162181051376 1.0985945751350226 0.958775085404107 0.9259810206268781 0.9408317220695117 1.0533417100950064 0.9897370174520664 0.9791564850507398 1.011973951215014 1.0 15.315387569421988 -6.747616771493432 24.998891623124408 1.0044700777723268 0.9807248270595303 0.08222213475441631 0.047446015727519546 866.3545187241635 1566843.9791353403 0.0169387806083402 0.016845908068211072 1.7880646962485888e-07 6.747616771493432 -0.02374525071279643 ELSSEPQT(ph)PPAQK ddPTM_A459_Selumetinib_30min_R2 2 ELSSEPQTPPAQK 13 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 ELS(0.005)S(0.005)EPQT(0.99)PPAQK;ELSS(0.001)EPQT(0.999)PPAQK 160.87 2.8093e-05 7108100.0 55939.0 56307.0 61102.0 65637.0 67965.0 48830.0 47886.0 56077.0 52700.0 74521.0 True False 52830.1343215594 60625.5658444589 57170.7638428275 56697.12736985942 59426.62908519094 55555.88926539345 50112.7938843089 56240.174785952906 63241.47256102976 72369.38510118928 0.7300066768246068 0.837723932014763 0.7899854857532566 0.7834407780387191 0.8211570265810418 0.7676711524868335 0.6924584727953612 0.7771266082655811 0.87387052512058 1.0 16.143091893105073 -8.547954372797728 2.6799843172083557 0.9991924856367241 0.7765301054336302 0.763506978083456 0.0392660603435079 0.1389174901568234 2.4481446475890154 0.039887499700961795 0.010744775010112213 2.831689478929446e-09 8.547954372797728 -0.22266238020309392 ELSSPIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ELSSPISPK 9 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 ELS(0.016)S(0.184)PIS(0.8)PK 129.89 0.0036778 0.0 2758.2 3188.8 2931.3 2750.5 2523.5 2654.0 2860.0 2695.3 1804.4 2430.2 True False 2822.4606934770623 2815.4538135670987 2533.24556047834 2270.1768082795015 2295.2498705601097 2627.303169639195 2644.2678974007913 2623.8118884317278 3061.935011838247 2742.1398421525882 1.029291303853206 1.0267360439783255 0.9238207043772554 0.8278851331292447 0.8370287449520923 0.9581215112562436 0.9643081861664038 0.9568483153550722 1.116622487580582 1.0 11.42108643143043 -8.11590839774164 5.4903095765502385 1.0569668075250656 0.9353727180647905 0.32355375365719596 0.06838697689434062 0.28909862063197556 11.712858166614113 0.0535576120505988 0.01957803887468547 7.657581051057954e-09 8.11590839774164 -0.12159408946027506 ELSSPIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ELSSPISPK 9 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 ELS(0.465)S(0.055)PIS(0.48)PK;ELS(0.223)S(0.094)PIS(0.683)PK 96.334 0.021576 37711000.0 160607.0 145750.0 136910.0 125505.0 123311.0 93322.0 116395.0 116330.0 73780.0 122949.0 True False 151681.10590076135 156928.55633988438 128101.35965633692 108411.00249179882 107819.56976567321 106176.25840723004 121807.59813231695 116668.50104053189 88538.06158544168 119399.14291013443 1.270370140051373 1.3143189516694973 1.0728834105011307 0.9079713626872028 0.9030179542144907 0.8892547787143115 1.0201714615656432 0.9771301384327545 0.7415301268291323 1.0 16.86543295489433 -5.460992991815563 2.7409535661582587 0.9212475858477106 1.295618050856462 0.7976960492674189 0.0744725916251925 0.1137933987222499 1.6641066384443883 0.020768892092048127 0.049396884523236956 3.459449602744978e-06 5.460992991815563 0.3743704650087515 ELST(ph)SPCNPIVR ddPTM_A459_Selumetinib_30min_R1 1 ELSTSPCNPIVR 12 0 H3BSS6;Q9H2Y7;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 ELS(0.015)T(0.921)S(0.064)PCNPIVR 217.91 1.0607e-07 49087000.0 3299.3 3796.2 4556.2 4689.7 3816.8 3571.2 3730.5 3449.9 2109.1 2794.7 True False 3376.167270679749 3351.7391391944984 3937.4930654151453 3870.7319315718482 3471.5711139107707 3535.2769703901645 3449.1053815572186 3358.397445145481 3578.9886574307475 3153.4269676832505 1.0706343623236472 1.0628878276058327 1.2486393709976833 1.227468392716761 1.1008883825399811 1.1210904855638533 1.093764154649567 1.0649992784240117 1.1349521311603887 1.0 11.622704805922108 -7.061142714963192 1.5077509291516875 1.0750899456353427 1.1495333996413286 0.2132469442663505 0.06392619553199953 0.7366367748201437 3.360371084309439 0.03591343664414511 0.025338705662977364 8.686749242043627e-08 7.061142714963192 0.07444345400598595 ELST(ph)SPCNPIVR ddPTM_A459_Selumetinib_30min_R2 2 ELSTSPCNPIVR 12 0 H3BSS6;Q9H2Y7;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 ELS(0.019)T(0.761)S(0.22)PCNPIVR;ELS(0.001)T(0.933)S(0.066)PCNPIVR 228.62 1.7009000000000004e-09 61940300.0 155631.0 148924.0 162741.0 181479.0 195518.0 136521.0 139818.0 154684.0 126060.0 160556.0 True False 146981.6520602551 160345.9919338664 152270.42123900316 156761.24713126346 170955.28088690265 155325.52853575235 146319.8140441111 155134.10483068522 151275.52241069084 155920.3311054139 0.942671497797708 1.028384116407888 0.9765911870470366 1.0053932416631481 1.0964271283603417 0.9961852148116629 0.9384267786424072 0.9949575127941644 0.9702103717854291 1.0 17.250449533790913 -9.864714583898838 10.805963368439178 0.999999974543895 0.9965913625781193 0.0 0.04294729463049605 0.0 0.0 0.043097166344834674 0.010452598176739294 1.3654802283618728e-10 9.864714583898838 -0.0034086119657756875 ELSTS(ph)PCNPIVR ddPTM_A459_Selumetinib_30min_R1 1 ELSTSPCNPIVR 12 0 H3BSS6;Q9H2Y7;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 ELS(0.005)T(0.067)S(0.927)PCNPIVR 213.99 2.1445e-06 51212000.0 3722.6 4119.4 4842.3 5038.5 4621.5 3869.9 4410.0 3961.3 2014.7 3155.3 True False 3809.329337081329 3637.0987329428967 4184.742256849954 4158.620559358759 4203.486140992094 3830.972319588064 4077.3501494886314 3856.2334558841694 3418.798752133959 3560.313490224701 1.0699421125528223 1.0215669892353636 1.1753858946240836 1.168048985230314 1.1806505670170073 1.0760210667140664 1.145222228515416 1.0831162667197578 0.9602521692319261 1.0 11.79778856261793 -8.130845710887172 3.9516511810951 0.981127135455131 1.1202217101390493 0.5473746848262655 0.04983660910308444 0.19047385802104538 4.928849768264039 0.04092014741199996 0.01401170512838088 7.398680767262421e-09 8.130845710887172 0.13909457468391828 ELSVQDQPSLSPT(ph)SLQNSSSHTTTAK ddPTM_A459_Selumetinib_30min_R1 1 ELSVQDQPSLSPTSLQNSSSHTTTAK 26 0 O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-3 CNOT4 CCR4-NOT transcription complex subunit 4 1 ELSVQDQPS(0.001)LS(0.36)PT(0.638)S(0.001)LQNSSSHTTTAK 203.73 2.7126e-32 8261400.0 1617.7 1468.2 1587.6 1656.1 4120.7 2050.1 3244.8 2140.5 208.77 757.13 True False 1655.3892625037502 1296.3024614523374 1372.0126400625702 1366.8932238471843 3747.9834125686757 2029.4778553418666 3000.042123596532 2083.7269866761067 354.26744204249087 854.315010570731 1.9376801788813893 1.5173588727960352 1.6059797885863993 1.599987366409519 4.387121104269032 2.375561508612684 3.511634568602901 2.439061658631116 0.41468010939643923 1.0 9.738624320968146 ELSVQDQPSLSPT(ph)SLQNSSSHTTTAK ddPTM_A459_Selumetinib_30min_R2 3 ELSVQDQPSLSPTSLQNSSSHTTTAK 26 0 O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-3 CNOT4 CCR4-NOT transcription complex subunit 4 1 ELSVQDQPS(0.003)LS(0.013)PT(0.982)S(0.001)LQNSSSHTTTAK;ELSVQDQPS(0.004)LS(0.071)PT(0.9)S(0.026)LQNSSSHTTTAK;ELSVQDQPS(0.001)LS(0.155)PT(0.753)S(0.092)LQNSSSHTTTAK 188.07 2.2347e-27 27592200.0 47324.0 46703.0 89962.0 148910.0 182927.0 107823.0 59805.0 82463.0 123131.0 150250.0 True False 44693.92153298191 50284.96992618616 84173.94286321981 128628.20111592211 159946.07487187092 122674.63953025853 62586.051001359345 82702.95367751535 147760.64056759322 145911.8921036174 0.30630760035133475 0.3446255764436044 0.5768819912460925 0.8815470710542119 1.0961825836532044 0.8407446285676479 0.4289304325991105 0.5668006389690632 1.0126703069730805 1.0 17.154737944942404 -5.467453992590652 2.8917208387310085 0.8076569603357604 0.3233188551030776 0.5233401721533917 0.1934190782246106 0.24156435678186022 3.9511276779869484 0.05934422038626024 0.13724719192973725 3.4083642972740124e-06 5.467453992590652 -0.4843381052326828 ELT(ph)DEEAER ddPTM_A459_Selumetinib_30min_R2 2 ELTDEEAER 9 0 A0A0A0MSS4;A0A0A0MSU9;Q9Y266 A0A0A0MSS4 NUDC Nuclear migration protein nudC 1 ELT(1)DEEAER;ELT(1)DEEAER 147.62 0.0037867 40563000.0 96219.0 95704.0 85066.0 107985.0 106348.0 71981.0 101413.0 105114.0 64543.0 68528.0 True False 90871.53317517502 103044.18906313779 79592.94617285776 93277.25671548468 92987.61347681707 81895.72937153984 106128.9054460471 105419.86433744043 77453.40348209765 66549.41858287338 1.3654744866330206 1.5483860153461417 1.1959976190286532 1.4016239165084121 1.397271613440476 1.230600223344639 1.59473828180611 1.5840839271369749 1.163847936336899 1.0 16.02213844146018 -8.48953741549729 5.545964299078176 1.000531269024136 1.4099053023781125 0.536905594432226 0.12808817128469296 0.12446236351167271 10.967574459139056 0.12587501043572186 0.03267344262115008 3.239385131631899e-09 8.48953741549729 0.4093740333539766 ELTDS(ph)PATSK ddPTM_A459_Selumetinib_30min_R2 1 ELTDSPATSK 10 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ELT(0.001)DS(0.999)PATSK 155.99 0.00051622 3202800.0 21705.0 19147.0 20934.0 26536.0 27175.0 20248.0 25379.0 26605.0 26458.0 25835.0 True False 20498.72299199925 20615.5133326914 19587.129231215837 22921.751022846718 23761.0335524176 23036.978206956523 26559.173787534444 26682.41614530516 31750.339298287006 25089.07642260871 0.8170377676209348 0.8216927951207478 0.7807034783299213 0.9136147794659778 0.9470668888794026 0.9182075026961549 1.0585951168613355 1.0635073087529294 1.2655045073590507 1.0 14.614771742881356 -6.940301474641652 0.8198384773133216 1.1308955847395772 0.8130581665293845 0.7310944589754955 0.07169052498450572 0.312107153829204 0.443341746121569 0.05018689973279042 0.03984548011094912 1.1473568830995177e-07 6.940301474641652 -0.31783741821019273 ELTHIYR ddPTM_A459_Selumetinib_30min_R2 2 ELTHIYR 7 0 P22059 P22059 OSBP Oxysterol-binding protein 1 0 ; 115.46 0.018306 3425700.0 22892.3 20393.5 27360.0 26635.2 25841.0 19195.8 18820.4 21739.3 19640.5 21840.6 False True 21620.03761113774 21957.6158745622 25599.687387315647 23007.439811717188 22594.622558528914 21839.847207877116 19695.58589191511 21802.557763865145 23569.148801421346 21210.00512930628 1.0193320312433547 1.0352480228410192 1.206962809827144 1.084744660430438 1.0652813340110645 1.029695517503698 0.9285988273855406 1.0279374111862012 1.1112278690048685 1.0 14.372457349311073 -6.666307788740126 2.964423744826262 1.0148615556953628 1.0900735361146214 0.20720860433120925 0.06239974287297428 0.42048951099386656 7.445081990398791 0.023710015124198965 0.02325820601665709 2.1562157363765893e-07 6.666307788740126 0.07521198041925858 ELTPAS(ph)PTCTNSVSK ddPTM_A459_Selumetinib_30min_R1 2 ELTPASPTCTNSVSK 15 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 ELTPAS(0.999)PT(0.001)CTNSVSK;ELTPAS(0.999)PTCTNSVSK 208.38 1.6281e-06 117515000.0 9858.400000000001 12381.1 11307.8 11476.099999999999 11923.0 10171.9 12477.7 11877.400000000001 6130.1 9691.0 True False 10088.081538892864 10931.515056182772 9772.262869299278 9472.014568077213 10844.566755176616 10069.579921346247 11536.497043146102 11562.372768767487 10402.33197521039 10934.934248333773 0.9225552993544566 0.999687314795558 0.8936736744245483 0.8662159600566894 0.9917358905774009 0.9208633259848465 1.0550129320534316 1.0573792677838296 0.9512935093135527 1.0 13.41665692504858 -7.2525440262351735 24.84780070682431 1.020703033316603 0.9334321441412846 0.4311372958914539 0.04683238409036081 573.0436155167228 1600711.7741611619 0.018383010761374177 0.014026111244148022 5.590568507832066e-08 7.2525440262351735 -0.08727088917531833 ELTPAS(ph)PTCTNSVSK ddPTM_A459_Selumetinib_30min_R2 3 ELTPASPTCTNSVSK 15 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 ELT(0.026)PAS(0.968)PT(0.004)CT(0.002)NSVSK;ELT(0.001)PAS(0.957)PT(0.042)CTNSVSK;ELT(0.001)PAS(0.994)PT(0.005)CTNSVSK 193.32 3.1012e-05 108415000.0 181890.0 163273.0 178424.0 175736.0 191409.0 136543.0 146811.0 157240.0 124382.0 167062.0 True False 171781.28196336064 175795.5140945591 166944.39409336259 151800.45363849105 167362.4902018289 155350.55883605592 153638.0024004776 157697.54236751675 149261.87552345343 162238.48598079532 1.058819557670767 1.0835623436190631 1.029006114573359 0.9356624152450495 1.0315831609870925 0.9575444315625903 0.946988635105139 0.972010687933712 0.9200152147692134 1.0 17.307756568637558 -5.561885656432515 4.449160361104654 0.9668618626148331 1.0689324668161644 0.66318497424416 0.030596590769112916 0.11223078645357265 4.991533586673722 0.008274412090337736 0.015441383362246687 2.742296084490961e-06 5.561885656432515 0.1020706042013313 ELTPASPTCT(ph)NSVSK ddPTM_A459_Selumetinib_30min_R1 1 ELTPASPTCTNSVSK 15 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 ELT(0.012)PAS(0.013)PT(0.426)CT(0.473)NS(0.074)VS(0.002)K 142.1 0.00089516 8129000.0 2152.7 2756.9 2266.2 2711.6 2590.2 2308.4 2630.1 2475.7 1083.0 1874.4 True False 2202.853721574967 2434.120866351962 1958.4624873455523 2238.069963036063 2355.9168673369536 2285.179591859503 2431.709439494342 2410.036393793058 1837.7719008095867 2114.9974982021295 1.0415396346556063 1.1508859317427589 0.9259880869884523 1.0581903595340196 1.1139100019454489 1.080464442062952 1.1497457758514777 1.1394984607980523 0.8689239123789978 1.0 11.046440241466643 -8.259545346470377 24.999558091271663 0.9344619538860091 1.0819950897580732 0.41820592059295725 0.06985386219218381 159.02318088852462 2099038.5069136526 0.05367572219953499 0.017949575340515715 5.501164775912475e-09 8.259545346470377 0.14753313587206418 ELTPASPTCT(ph)NSVSK ddPTM_A459_Selumetinib_30min_R2 1 ELTPASPTCTNSVSK 15 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 ELT(0.159)PAS(0.101)PT(0.046)CT(0.651)NS(0.043)VSK 133.42 0.0012609 32544000.0 90235.0 71757.0 88208.0 83918.0 82563.0 53471.0 68374.0 85369.0 59511.0 77101.0 True False 85220.09993932508 77260.53116487879 82532.79331360872 72488.22363337557 72190.69781741504 60836.144888590105 71553.52648051069 85617.4096564013 71414.86287627033 74874.89379754434 1.1381665551306603 1.0318616460917462 1.1022759315929145 0.9681245602748749 0.964150921036534 0.8125039222504424 0.9556411081394738 1.1434728693960337 0.9537891708984636 1.0 16.192194431135484 -5.766303047571125 24.91646746422385 0.9695340049567431 1.0848774146204447 0.32480143630528024 0.0789090269511002 150.64988110020332 771781.2630295205 0.023836777610939185 0.036666142076480904 1.7127617375844683e-06 5.766303047571125 0.1153434096637016 ELTS(ph)SGGPTK ddPTM_A459_Selumetinib_30min_R2 1 ELTSSGGPTK 10 0 Q96EE3;Q96EE3-1 Q96EE3 SEH1L Nucleoporin SEH1 1 ELT(0.001)S(0.967)S(0.029)GGPT(0.002)K 107.34 0.0086402 0.0 58770.0 43558.0 54115.0 57040.0 62847.0 54044.0 53997.0 63619.0 49379.0 46257.0 True False 55503.798674950296 46898.75853895508 50633.29981595705 49271.05360051167 54951.59800069142 61488.070437413924 56507.96749302565 63804.12075730759 59256.17976453679 44921.440219880424 1.2355747812908844 1.0440172512144785 1.1271521920962095 1.0968271132746603 1.2232821951325605 1.3687911637837866 1.2579286687254854 1.4203489568678265 1.319106855757318 1.0 15.45511656206915 -6.467338689409711 4.144636792090898 1.2989299158560799 1.1215461708209313 0.25441252233051426 0.11449110817709017 0.24681515853212685 8.655227885510097 0.03496525619559167 0.03866861698699786 3.4092693224020955e-07 6.467338689409711 -0.17738374503514853 ELVEFAQDDDR ddPTM_A459_Selumetinib_30min_R2 2 ELVEFAQDDDR 11 0 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 0 ; 160.18 0.0041692 0.0 20371.3 21949.0 23627.0 24794.0 27633.0 20335.2 21086.8 24614.0 17111.9 23294.0 False True 19239.14469877514 23632.417722841365 22106.864543132542 21417.014427964335 24161.495497845648 23136.189215433722 22067.377982701502 24685.62266493293 20534.758146434255 22621.44169491957 0.8504826950572278 1.0446910520362125 0.9772526809419669 0.9467572720077461 1.0680793834316913 1.0227548503519897 0.9755071440763874 1.091248869008952 0.9077563854405464 1.0 14.4654032567035 -4.752497120355138 24.898959702512936 1.0057419726838646 0.8504823811374791 0.431303986278317 0.05276645172961902 302.35023228863264 841803.453246132 0.012384047557388532 0.14577453891812225 1.768083941201158e-05 4.752497120355138 -0.15525959154638547 ELVEFAQDDDRLR ddPTM_A459_Selumetinib_30min_R2 2 ELVEFAQDDDRLR 13 1 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 0 ; 177.42 0.00029287 8665800.0 25203.0 23754.0 28676.0 32966.0 31799.0 19351.1 24603.4 23927.5 22434.7 26542.0 False True 23802.318155602738 25575.85541885162 26831.017380068082 28475.973930478045 27804.125333333115 22016.53837320409 25747.50685071221 23997.125063589152 26922.266877892507 25775.66349560211 0.9234415307937245 0.9922481888086185 1.040943810608252 1.1047620145776913 1.0786967845881874 0.8541599085106224 0.9989076267660498 0.930999315213887 1.0444839521778375 1.0 14.653721944271629 -6.708041105221238 24.999975469976512 0.9634694411277135 1.031012754440165 0.1829172563208762 0.06560666009499151 164.38441031042993 76960.59664712052 0.02235997921802395 0.022359958438109014 1.9586592810207752e-07 6.708041105221238 0.06754331331245156 ELVEPLT(ph)PSGEAPNQALLR ddPTM_A459_Selumetinib_30min_R1 2 ELVEPLTPSGEAPNQALLR 19 0 P00533;E9PFD7;Q504U8 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 ELVEPLT(0.999)PS(0.001)GEAPNQALLR;ELVEPLT(0.997)PS(0.003)GEAPNQALLR 219.85 7.4595e-19 122250000.0 7776.7 5439.6 9660.3 5242.4 9230.8 6884.9 10836.2 14268.8 5306.200000000001 6815.0 True False 7957.881979175939 4802.729103198566 8348.48432022956 4326.9132520357925 8395.875769830107 6815.644156989038 10018.81670972533 13890.345072405533 9004.233850485536 7689.7716337214615 1.0348658397446746 0.6245606933419799 1.085660890580871 0.5626842327880399 1.09182381086744 0.8863259510985776 1.3028757142527427 1.8063403874691277 1.170936443808012 1.0 12.908725039183441 -7.297758568786172 4.207118687247411 1.3979762674588072 0.8710536449997255 0.40390926039663844 0.2562060402863162 0.18397614361979406 7.447417704977965 0.10391463790855507 0.07057947834849383 5.037805906049738e-08 7.297758568786172 -0.5269226224590817 ELVEPLT(ph)PSGEAPNQALLR ddPTM_A459_Selumetinib_30min_R2 6 ELVEPLTPSGEAPNQALLR 19 0 P00533;E9PFD7;Q504U8 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 ELVEPLT(0.969)PS(0.031)GEAPNQALLR;ELVEPLT(0.95)PS(0.05)GEAPNQALLR;ELVEPLT(0.941)PS(0.059)GEAPNQALLR;ELVEPLT(0.992)PS(0.008)GEAPNQALLR;ELVEPLT(0.843)PS(0.157)GEAPNQALLR;ELVEPLT(0.954)PS(0.046)GEAPNQALLR 188.96 6.2834e-15 69630200.0 139413.0 42942.899999999994 107605.6 109551.8 71038.0 56199.0 195940.0 143780.0 128668.1 109979.1 True False 131664.9835744573 46236.48234681326 100682.37284811889 94630.65585260406 62113.57135222233 63939.90212627166 205051.59824774417 144198.37599593968 154405.31528709372 106803.71762298139 1.2327752863363475 0.43291079539036914 0.9426860327421286 0.8860239882908533 0.5815675028418402 0.5986673830210706 1.9198919551806162 1.3501250631084019 1.4456923291017512 1.0 16.704602339654166 -7.245664100631987 24.976920853901063 1.4581044486264212 0.7666854918531963 0.5366494851272239 0.2951750510868927 566.1808886318585 896432.548733533 0.10776198791992625 0.08318554457176378 5.6798373513368604e-08 7.245664100631987 -0.6914189567732248 ELVGPPLAETVFT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 ELVGPPLAETVFTPK 15 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 ELVGPPLAET(0.02)VFT(0.98)PK;ELVGPPLAETVFT(1)PK 207.39 4.3058e-06 51923000.0 10388.5 12612.900000000001 7776.599999999999 6610.6 8034.4 7951.599999999999 11572.7 11631.1 5806.1 12772.8 True False 10630.531837497823 11136.175804421871 6720.580433806111 5456.182806330653 7307.689938588528 7871.614123475143 10699.761921765776 11322.605444862633 9852.52763923412 14412.313297607847 0.7376006625711 0.7726848268189016 0.4663082390057113 0.3785778655836096 0.5070448988783401 0.5461728426887357 0.7424041998546979 0.7856202686588805 0.6836187526446182 1.0 13.815014298346883 -7.370649764998281 3.4038621073386484 0.7967881284503798 0.5609319104425948 0.4327669394093193 0.13270711028268178 0.2898720155181383 6.264515568532638 0.06640219163955273 0.04255696740550619 4.259417736587429e-08 7.370649764998281 -0.235856218007785 ELVGPPLAETVFT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ELVGPPLAETVFTPK 15 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 ELVGPPLAET(0.38)VFT(0.62)PK;ELVGPPLAET(0.005)VFT(0.995)PK 192.23 6.9377e-05 7895600.0 41385.0 28363.0 37777.0 47130.0 38978.0 36353.0 52035.0 52674.0 45192.0 33981.0 True False 39084.98737728123 30538.350898580793 35346.468948487665 40710.8126962152 34081.23517225879 41360.295770322504 54454.730605396435 52827.2726193499 54231.66276998212 32999.8802367589 1.1843978552911252 0.9254079311646657 1.0711090069083 1.2336654679996994 1.032768450301688 1.2533468447031166 1.6501493403827192 1.6008322527336043 1.6433896844744582 1.0 15.010173168197888 -7.048475372781692 4.219851912250369 1.521169798109598 1.0897740089833283 0.4609529663446641 0.19267460408120926 0.17132528733360108 6.4419546375543915 0.07138318090928758 0.05645153788407482 8.94385247742142e-08 7.048475372781692 -0.43139578912626964 ELVGPPLAETVFT(ph)PKT(ph)SPENVQDR ddPTM_A459_Selumetinib_30min_R1 1 ELVGPPLAETVFTPKTSPENVQDR 24 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 2 ELVGPPLAET(0.104)VFT(0.857)PKT(0.501)S(0.538)PENVQDR 67.56 0.0041631 9302000.0 1275.8 1158.5 1865.9 1984.1 1313.1 1615.6 1443.2 1200.0 936.08 1130.6 True False 1305.5236577253424 1022.8622814279612 1612.5210286550462 1637.6141811697341 1194.3303368466347 1599.348530847432 1334.338262073014 1168.1721018506564 1588.4593914218265 1275.7235229765938 1.0233593989700975 0.8017899356761552 1.2640050917087555 1.2836748336730168 0.9361984123800997 1.253679580286908 1.0459462713046608 0.9156937853783615 1.24514392249783 1.0 10.317099984258924 -5.255158993611521 24.99447060158552 1.1167220920938992 0.912574675027876 0.25149355467608026 0.14177306068218604 690.432744335537 2747741.3717168914 0.03584383235336539 0.08995622245705588 5.557007800160825e-06 5.255158993611521 -0.20414741706602313 ELVGPPLAETVFT(ph)PKT(ph)SPENVQDR ddPTM_A459_Selumetinib_30min_R2 1 ELVGPPLAETVFTPKTSPENVQDR 24 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 2 ELVGPPLAET(0.016)VFT(0.739)PKT(0.622)S(0.622)PENVQDR 71.001 0.0024328 2460300.0 9835.2 8510.0 8545.0 8082.9 9219.0 6298.0 7918.6 6934.2 6432.3 8316.2 True False 9288.598957425065 9162.68963603718 7995.224003092549 6981.995076219767 8060.826801094307 7165.492332448248 8286.830590408228 6954.377373981394 7718.939733478402 8076.089697917501 1.1501356850729656 1.134545303329143 0.9899870236897189 0.8645266877137512 0.9981101130133399 0.8872477399917859 1.0260944219756585 0.8611070003066766 0.9557768700202532 1.0 12.97944121886071 -5.322796435187289 3.414300096916819 0.9389715786755523 1.1477261667758127 0.6764005930172781 0.054558832726618475 0.11985119874742244 2.758438734093805 0.013544404284487969 0.03398384848975941 4.755580798152542e-06 5.322796435187289 0.20875458810026049 ELVLDNS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 ELVLDNSR 8 0 P39687;H0YN26;H7BZ09 P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 ELVLDNS(1)R;ELVLDNS(1)R 92.611 0.025221 4714300.0 2702.8 3960.5 2844.4 3094.0 3222.9 3154.4 4324.2 3736.9 1720.19 3005.1 True False 2765.7699812667 3496.8028188135013 2458.146103170809 2553.6909815730855 2931.3892640492113 3122.6695999660437 3998.0221125666044 3637.7852728380967 2919.036792293302 3390.833857152803 0.8156607188029693 1.031251593597593 0.7249385274319669 0.7531159263926175 0.8645039502202636 0.9209149523439258 1.1790675335310123 1.0728291110944175 0.8608610493067163 1.0 11.727424382108934 -6.996423402251975 4.499945727303592 1.0370407463470206 0.8403603231391777 0.41323846848543355 0.10629527743772972 0.20171473233762535 10.410772995811374 0.04146150217735753 0.034400242320569194 1.0082694250175846e-07 6.996423402251975 -0.19668042320784285 ELVLDNS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 ELVLDNSR 8 0 P39687;H0YN26;H7BZ09 P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 ELVLDNS(1)R;ELVLDNS(1)R 106.16 0.013847 6647000.0 36993.0 36647.0 47931.0 46354.0 43625.0 39814.0 39866.0 43423.0 34748.0 39897.0 True False 34937.077154712206 39457.7070613225 44847.171643326976 40040.50523488986 38144.43748755173 45298.01710449264 41719.84799298036 43549.353740935396 41698.57094024026 38745.06994514492 0.9017167140019607 1.018392975343354 1.1574936296881484 1.033434841944511 0.984497835248625 1.1691298317082754 1.076778234032023 1.1239972931418722 1.0762290789325426 1.0 15.241725128176709 -4.868519224923655 3.4770873803919273 1.0809277540805378 0.8950351687539725 0.4557927025297599 0.05832327179327107 0.2243488086342813 4.565684594412874 0.014617563078755435 0.09570818161525348 1.3535701708238563e-05 4.868519224923655 -0.18589258532656527 ELVPLPEYSGITS(ph)LCK ddPTM_A459_Selumetinib_30min_R1 1 ELVPLPEYSGITSLCK 16 0 Q9P225-2;Q9P225 Q9P225-2 DNAH2 Dynein heavy chain 2, axonemal 1 ELVPLPEY(0.001)S(0.1)GIT(0.1)S(0.799)LCK 87.49799999999998 0.031935000000000005 0.0 2133.8 1232.1 2193.1 1454.9 2267.7 1547.5 1502.5 2343.4 839.88 1545.3 True False 2183.5133883479657 1087.8451592122494 1895.289065835994 1200.8290268554247 2062.586935394952 1531.9335550175795 1389.1652153303103 2281.2454195640216 1425.2150175918346 1743.6543074966642 1.2522627787860083 0.623888092115031 1.086963773545818 0.6886852638694393 1.1829104694245123 0.8785764176024956 0.796697607638014 1.3083128976632807 0.8173724639478523 1.0 10.767898328047952 ELVSSKVS(ph)GAQEMVSSAK ddPTM_A459_Selumetinib_30min_R1 1 ELVSSKVSGAQEMVSSAK 18 1 K7EL96;K7ER39;O60664-3;O60664;K7ERZ3 K7EL96;O60664-3 PLIN3 Perilipin-3 1 ELVS(0.028)S(0.147)KVS(0.825)GAQEMVSSAK 79.635 0.006562999999999999 14261000.0 1588.1 1527.2 2239.1 2467.2 2500.9 1815.9 2092.4 2175.1 931.8 1538.9 True False 1625.0996400953254 1348.3947140239825 1935.042518495908 2036.3498350798695 2274.694036569757 1797.633694705282 1934.5685833990958 2117.409282279469 1581.196544020658 1736.4328051553866 0.9358839773531585 0.7765314672820408 1.1143780011244078 1.1727202049132242 1.3099810311209845 1.0352451815976944 1.114105065082538 1.2194017965987405 0.9106004789394444 1.0 10.761910868405558 -5.274287615104243 23.497508638179497 1.1243124798751638 0.8562077430364647 0.44128454216944746 0.1130561792258301 248.53880288733728 454541.7890720346 0.028855168881511486 0.06079791451322119 5.317559828432361e-06 5.274287615104243 -0.26810473683869906 ELVSSSSSGS(ph)DSDSEVDKK ddPTM_A459_Selumetinib_30min_R2 1 ELVSSSSSGSDSDSEVDKK 19 1 P53999;D6RC37;D6R970 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 ELVSS(0.002)S(0.009)S(0.011)S(0.044)GS(0.863)DS(0.071)DSEVDKK 111.4 0.00031594 19015000.0 40895.0 28535.0 37428.0 25572.0 21764.0 20594.0 25292.0 28582.0 15902.0 19341.0 True False 38622.21961565583 30723.54274551362 35019.92322852519 22089.04948583948 19029.81174737137 23430.636566281246 26468.128115147218 28665.168887995187 19082.844339003706 18782.575076047033 2.056279261990536 1.6357471018281522 1.8644899906821222 1.1760394619164396 1.0131630870806225 1.2474666796972782 1.4091852692180311 1.5261575567745866 1.0159865865964033 1.0 14.197107248439229 -5.760676347230384 24.998818639609492 1.2233319783701888 1.830529740571311 0.7146734622662374 0.18872218138203478 11.678744092941614 382595.6775971529 0.05354446113740163 0.08617435557896007 1.7350965760311473e-06 5.760676347230384 0.6071977622011222 ELVSSSSSGSDS(ph)DSEVDKK ddPTM_A459_Selumetinib_30min_R1 1 ELVSSSSSGSDSDSEVDKK 19 1 P53999;D6RC37;D6R970 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 ELVSSSSSGS(0.015)DS(0.984)DSEVDKK 122.53 0.00021561 9759700.0 1676.9 2003.0 2433.2 1814.7 1379.4 1146.6 1159.3 1387.7 783.02 1146.1 True False 1715.9685073206028 1768.4878288305624 2102.7848046108898 1497.796711137905 1254.6335135528502 1135.0662450295033 1071.8530676422156 1350.8936881151299 1328.727750481924 1293.2130989593788 1.3269031288821667 1.367514627135796 1.6260157017454866 1.1581979121176165 0.9701676502986455 0.8777101360501738 0.8288294237853862 1.0446025401398775 1.0274623351334153 1.0 10.33674431037515 -5.999499305828529 3.9658969984094377 0.9543976875457011 1.4328580239338577 0.8314073566732324 0.09682602860571174 0.08599625479840442 3.0979219475217215 0.030414737436224786 0.04385334569789085 1.001153555769602e-06 5.999499305828529 0.47846033638815666 ELVSSSSSGSDS(ph)DSEVDKK ddPTM_A459_Selumetinib_30min_R2 1 ELVSSSSSGSDSDSEVDKK 19 1 P53999;D6RC37;D6R970 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 ELVSSSSSGS(0.004)DS(0.944)DS(0.051)EVDKK 100.47 0.00065175 17426000.0 76971.0 67100.0 70019.0 52822.0 46668.0 45914.0 53371.0 47973.0 41522.0 43739.0 True False 72693.25995932613 72246.35423949419 65514.05377092307 45627.552476967496 40805.148622786546 52238.23673420592 55852.857252630216 48112.59348764231 49827.560221614396 42476.14142243014 1.7113903835186735 1.7008690483675493 1.5423730022785787 1.0741924984003657 0.9606604379850472 1.229825379256807 1.3149230457909793 1.1326968946909985 1.1730717186872872 1.0 15.374365095701826 -5.639853892484753 3.9154525080440483 1.137426789482933 1.6904481803139444 0.8565531367424718 0.09959676110878686 0.08411079422727483 2.3785694877598735 0.030314124994569508 0.05516336858443336 2.291638487543885e-06 5.639853892484753 0.5530213908310113 ELVSSSSSGSDSDS(ph)EVDKK ddPTM_A459_Selumetinib_30min_R1 1 ELVSSSSSGSDSDSEVDKK 19 1 P53999;D6RC37;D6R970 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 ELVS(0.001)S(0.003)S(0.014)S(0.018)S(0.062)GS(0.031)DS(0.287)DS(0.584)EVDKK 110.34 0.00033871 8538600.0 1861.1 1702.2 1972.5 1795.3 1512.6 1818.4 1779.0 1741.6 1053.5 1522.7 True False 1904.4600089297955 1502.9056326686898 1704.6453341669326 1481.7845569548035 1375.7855970712203 1800.1085469750988 1644.808597718883 1695.4071104859177 1787.7125554043394 1718.1533773540239 1.1084342259727045 0.8747214611207655 0.992138045785008 0.8624285680692657 0.8007350305302464 1.0476995655342987 0.9573118555061174 0.9867612128416988 1.040484847841371 1.0 10.746643114427867 EMDMSPEEVVAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 EMDMSPEEVVASPR 14 0 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 EMDMSPEEVVAS(1)PR;EMDMSPEEVVAS(1)PR 210.37 4.4403e-06 26428000.0 4053.5 4487.9 3744.8 3176.8999999999996 4261.2 3397.8 3942.6000000000004 4373.7 2110.85 4037.8999999999996 True False 4147.938663262011 3962.454581631893 3236.27672871398 2622.1140527988155 3875.775212375963 3363.621216955561 3645.206507794528 4257.695268220179 3581.9582796158043 4556.203797476727 0.9103935749228738 0.8696833499472392 0.7103011350164502 0.5755041190762734 0.8506588784554385 0.7382508260096639 0.8000534369892061 0.9344830603446963 0.7861716549201617 1.0 12.15361656441954 -7.631354539466329 5.334629046298319 0.8943143832913338 0.7712449417997819 0.24797953615725266 0.10152544543966019 0.33502394633685023 14.400988250461136 0.05158753753175101 0.02905395246154224 2.336928690963746e-08 7.631354539466329 -0.12306944149155197 EMDMSPEEVVAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 EMDMSPEEVVASPR 14 0 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 EMDMSPEEVVAS(1)PR;EMDMSPEEVVAS(1)PR 205.33 1.3341e-05 19798000.0 25612.0 27659.0 31324.0 36952.0 39687.0 35770.0 30088.0 39308.0 32946.0 31419.0 True False 24188.58757295945 29780.356362297563 29308.647942992488 31919.073854244514 34701.16425371839 40696.99281226961 31487.15161824092 39422.37977221029 39536.12058815346 30511.85183363432 0.7927603904491793 0.976025857908421 0.9605660155534874 1.0461205051821523 1.1373011524481131 1.3338093352763283 1.0319646211552291 1.2920349766759673 1.2957627352061065 1.0 14.897082122564198 -5.7244974533089925 0.9618223292294379 1.2047315880155136 0.8376064088772166 0.5638423732519218 0.10975966969894722 0.5015687453090494 0.8503225503124496 0.04292385812020737 0.1409785975875457 1.8858300279138774e-06 5.7244974533089925 -0.367125179138297 EMDRETLIDVAR ddPTM_A459_Selumetinib_30min_R1 1 EMDRETLIDVAR 12 1 P40227;P40227-2 P40227 CCT6A T-complex protein 1 subunit zeta 0 115.57 0.014718 6747800.0 3804.4 3541.7 5000.6 5557.8 4130.1 3825.7 3806.5 3761.5 2636.9 2954.4 False True 3893.0351179262334 3127.0361175083394 4321.545986329613 4587.234562827054 3756.5331842283776 3787.2169314576736 3519.3726403692704 3661.7328009260336 4474.626708443952 3333.6260182929855 1.167807995427063 0.9380284712049277 1.2963499692573497 1.376049544146524 1.1268610106876793 1.1360653266670127 1.0557190941806358 1.0984233926759002 1.3422701538474393 1.0 11.70287654980912 EMDRETLIDVAR ddPTM_A459_Selumetinib_30min_R2 2 EMDRETLIDVAR 12 1 P40227;P40227-2 P40227 CCT6A T-complex protein 1 subunit zeta 0 ; 142.76 0.0024846 9652900.0 28083.0 32919.0 33672.0 41459.0 37138.0 28164.0 22216.9 21386.0 19165.5 34593.0 False True 26522.259285156182 35443.781448731825 31505.5801793016 35812.21267923587 32472.392422067514 32043.335352663154 23250.029871952167 21448.229719357118 22999.135528812436 33594.21020659195 0.7894889959327547 1.0550562501920924 0.9378276788039948 1.0660233551854328 0.9666068117801944 0.9538350553743787 0.6920844314830767 0.638450184941347 0.684616051021181 1.0 15.035924992732445 -7.242853271717515 9.38330250133882 0.7236255247713447 0.9697789805358799 0.42157692170868455 0.11682316577046781 0.26757722333373174 129.2470005578094 0.04300134167568421 0.03253699969684536 5.716717458381599e-08 7.242853271717515 0.24615345576453518 EMDT(ph)ARTPLSEAEFEEIMNR ddPTM_A459_Selumetinib_30min_R1 2 EMDTARTPLSEAEFEEIMNR 20 1 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 EMDT(0.845)ART(0.155)PLSEAEFEEIMNR;EMDT(0.854)ART(0.146)PLSEAEFEEIMNR 108.96 0.00056911 38222000.0 2344.8 3250.0 3714.8999999999996 3197.1000000000004 3035.2 2348.75 2767.5 2639.2 1644.8899999999999 2116.8 True False 2399.429277813436 2869.4884891159913 3210.4369844850353 2638.78650199978 2760.6666959080826 2325.1237074943715 2558.7452468729657 2569.199842670208 2791.258191987703 2388.511899378075 1.0045707867053972 1.201370815805085 1.3441159683236137 1.1047826484292884 1.1558103171380094 0.9734612199754128 1.0712717184030844 1.0756487515675264 1.1686180808705602 1.0 11.221896348882183 -6.426499562193138 2.5946484244976302 1.0645531929526948 1.1811992441590171 0.20971566267637454 0.09460797025647147 0.44220068797423534 5.826814264727172 0.032999072398199984 0.03747943528859242 3.745419246069633e-07 6.426499562193138 0.11664605120632232 EMDTART(ph)PLSEAEFEEIMNR ddPTM_A459_Selumetinib_30min_R1 1 EMDTARTPLSEAEFEEIMNR 20 1 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 EMDT(0.032)ART(0.967)PLS(0.001)EAEFEEIMNR 73.984 0.0093628 15864000.0 1009.0 1600.0 1518.4 1389.1 1762.8 1232.5 1171.6 1338.6 833.69 983.11 True False 1032.5077368277712 1412.6712561801805 1312.2096199741793 1146.5197616364485 1603.355051247617 1220.1021690204627 1083.2252687394287 1303.0959796144075 1414.7110396915464 1109.3017448023338 0.9307726609694943 1.2734778997682943 1.1829149517906885 1.0335508503511337 1.4453732347940356 1.0998830342936785 0.9764928918708663 1.174699296850566 1.275316699284227 1.0 10.115436135749972 -10.03632130289399 13.502508217725987 0.9999962854478801 1.1577599035187711 0.09114205329235436 0.1462907930799802 0.0 0.0 0.13886272693684446 0.03367915827187721 9.197688499133554e-11 10.03632130289399 0.157763618070891 EMDTART(ph)PLSEAEFEEIMNR ddPTM_A459_Selumetinib_30min_R2 2 EMDTARTPLSEAEFEEIMNR 20 1 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 EMDT(0.124)ART(0.876)PLSEAEFEEIMNR;EMDT(0.425)ART(0.575)PLSEAEFEEIMNR 66.52 0.021569 13345200.0 17976.2 18739.5 21854.7 19425.6 20938.4 15245.2 15957.5 16270.4 15729.6 18668.1 True False 16977.154768430173 20176.759393010423 20448.592395598203 16779.79976897088 18307.931000328997 17345.0879178533 16699.555369186368 16317.744170290276 18875.959521745226 18129.103447451198 0.9364585964021857 1.112948549910068 1.1279428381480776 0.9255725092864413 1.0098641145380491 0.9567537616037971 0.9211462341528084 0.9000855567727711 1.0411965256008857 1.0 14.146019959683999 -5.771227540707398 24.977839951111857 0.9604877365370661 1.064499857120219 0.31661172613904964 0.06301525331595294 207.9730350597433 530714.8369888803 0.01760285141816912 0.02646971260074083 1.693450315435558e-06 5.771227540707398 0.10401212058315301 EMEAELEDER ddPTM_A459_Selumetinib_30min_R2 1 EMEAELEDER 10 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 157.34 0.0068372 14216000.0 130940.0 129790.0 142360.0 150080.0 164190.0 119790.0 131190.0 123460.0 106240.0 122900.0 False True 123662.87899435073 139744.47565937287 133200.71258984838 129638.84509755948 143562.98432277635 136289.98515464843 137290.59494805342 123819.2481600966 127490.96859362021 119351.55766745128 1.036122874398607 1.1708642802027125 1.116036649986462 1.086193156010344 1.2028580701291327 1.1419204559892935 1.1503041739143915 1.0374330304518824 1.068196939237674 1.0 16.864857869716516 -7.76762381030724 24.854923236164936 1.0396111998109878 1.131952755692976 0.4686644425855925 0.045715827709532406 125.5841755066087 504704.6161626049 0.02367663542596501 0.011821125646911682 1.7075608527823493e-08 7.76762381030724 0.09234155588198822 EMEAELEDERK ddPTM_A459_Selumetinib_30min_R1 3 EMEAELEDERK 11 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;; 123.67 0.005134399999999999 16968600.0 4683.5 5418.9 5625.9 5988.799999999999 5486.6 5467.8 4791.400000000001 4423.299999999999 2814.55 4431.0 False True 4792.616437495406 4784.452668821737 4861.9336808566495 4942.96850369906 4990.337998737904 5412.798896365181 4429.980840421732 4305.979715096673 4776.085783401315 4999.76201159498 0.9585689131564299 0.9569360817027054 0.9724330217280958 0.9886407577472268 0.9981151077120829 1.082611309060776 0.8860383414546802 0.8612369359002785 0.9552626249659611 1.0 12.287643708976814 -10.155972311161841 4.570662206610411 1.000000018886999 0.9625159072113678 0.03782998354587164 0.057163482249828264 20349653.618509848 56029393.210610084 8.23265710283418 0.01563897218583599 6.982769219358055e-11 10.155972311161841 -0.03748411167563126 EMEAELEDERK ddPTM_A459_Selumetinib_30min_R2 1 EMEAELEDERK 11 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 92.239 0.034216 8042900.0 24968.0 28297.0 23918.0 25817.0 27689.0 22080.0 20143.0 21868.0 17361.0 26109.0 False True 23580.378514823205 30467.28891080424 22379.14191994939 22300.68006319091 24210.460277199298 25121.319577716316 21079.689412597276 21931.63225955771 20833.68510686978 25355.165330671207 0.9300029484051083 1.2016205973600609 0.8826265428795358 0.8795320311405976 0.9548531812534781 0.9907771947094339 0.8313765316725407 0.8649768981402707 0.8216741967628994 1.0 14.629992061209443 -5.292608671984671 24.967832051944853 0.8999630399325426 1.0658118225460975 0.3730681182437977 0.08422047270747796 560.3651730355842 448873.6944049276 0.021342554829529084 0.04443466167924712 5.097900186457354e-06 5.292608671984671 0.16584878261355496 EMEDKVT(ph)SPEKAEEAK ddPTM_A459_Selumetinib_30min_R2 1 EMEDKVTSPEKAEEAK 16 2 P56211 P56211 ARPP19 cAMP-regulated phosphoprotein 19 1 EMEDKVT(0.877)S(0.123)PEKAEEAK 102.59 0.015786 28545000.0 84797.0 52600.0 43553.0 48960.0 41912.0 44319.0 78367.0 67045.0 35592.0 45686.0 True False 80084.32220928645 56634.250864342626 40750.84739692098 42291.56353928913 36646.63986196603 50423.53996217432 82011.22078126454 67240.08985010271 42711.39452357061 44366.926473516614 1.805045527710606 1.2764970523290269 0.9184960653347458 0.9532227472311766 0.8259900510313926 1.1365119013207508 1.8484764958920121 1.515545366664952 0.9626854487895569 1.0 15.43719699322143 -7.050292596597948 24.99834151403191 1.391475448406629 1.122422631946561 0.04529116412426948 0.3477293571214722 864.0453027925379 429477.9043831494 0.13850960576678706 0.10729085837664558 8.906506791469316e-08 7.050292596597948 -0.26905281646006807 EMEENFAVEAANYQDTIGR ddPTM_A459_Selumetinib_30min_R1 2 EMEENFAVEAANYQDTIGR 19 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ; 222.42 7.4468e-51 7876500.0 1931.8400000000001 1618.04 2008.76 1972.83 2250.52 1884.9299999999998 1950.82 1788.14 1080.1999999999998 1646.26 False True 1976.8481132937186 1428.5991245936116 1735.9814253288544 1628.3122751056349 2046.9608633615771 1865.9693155795048 1803.6680767858068 1740.7127185026927 1833.0205053134953 1857.5735069303425 1.0642098985145834 0.7690673447181021 0.93454251950308 0.8765802640006618 1.1019541653262481 1.0045197719594077 0.9709807283838716 0.9370895482780849 0.9867822180251583 1.0 10.859203586131535 -6.216608349537951 24.99599974644925 0.9958286009011016 0.9026292612901161 0.23380142294582973 0.07819796410230158 634.4679846327172 353753.86789755494 0.02239162360257837 0.028907325335974125 6.072837363681875e-07 6.216608349537951 -0.09319933961098548 EMEENFAVEAANYQDTIGR ddPTM_A459_Selumetinib_30min_R2 2 EMEENFAVEAANYQDTIGR 19 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ; 229.92 1.7099e-22 9162100.0 68725.0 64619.0 63946.0 71821.0 72876.0 58198.0 49436.0 51939.0 47909.0 63319.0 False True 64905.53962797282 69575.06951716643 59831.78397914053 62038.855901864394 63720.66536029378 66214.24623115639 51734.871955575596 52090.13389103566 57492.13868930506 61490.815947480594 1.0555322551486184 1.1314709106574647 0.9730198413734329 1.0089125497188374 1.036263129354434 1.0768152155878055 0.8413430714557835 0.847120551067755 0.9349711465596616 1.0 15.908083330221707 -7.256794291763376 24.999511500873783 0.8931187363266893 1.045259463837912 0.5873181311730113 0.05755527167584005 263.2713735753082 1416911.0407838237 0.022744430817765848 0.01702742166175753 5.536122715095016e-08 7.256794291763376 0.15214072751122276 EMEHNTVCAAGT(ph)SPVGEIGEEK ddPTM_A459_Selumetinib_30min_R1 7 EMEHNTVCAAGTSPVGEIGEEK 22 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 EMEHNTVCAAGT(0.5)S(0.5)PVGEIGEEK;EMEHNTVCAAGT(0.5)S(0.5)PVGEIGEEK;EMEHNTVCAAGT(0.958)S(0.042)PVGEIGEEK;EMEHNTVCAAGT(0.998)S(0.002)PVGEIGEEK;EMEHNTVCAAGT(0.999)S(0.001)PVGEIGEEK;EMEHNTVCAAGT(0.999)S(0.001)PVGEIGEEK;EMEHNTVCAAGT(0.841)S(0.159)PVGEIGEEK 283.08 2.0117999999999998e-78 427543000.0 34450.89 35465.4 37039.87 40959.50000000001 47285.0 35406.61 47291.1 34532.020000000004 9060.05 24168.629999999997 True False 35253.52870723733 31313.09448058285 32010.059099442187 33806.6922300397 43008.08009884479 35050.4516500297 43723.89425271698 33616.11865379075 15374.243130129178 27270.909082892063 1.2927155673498625 1.148223346181979 1.1737804193525454 1.2396613595565007 1.5770680752929196 1.2852689121397132 1.6033163441605405 1.2326731958810733 0.5637598322592754 1.0 14.735075173221027 -9.730840733058175 8.860905257402349 1.0000301255341761 1.2532174355617227 0.06081527136476095 0.2689474858041585 0.0 0.0 0.26464123691975605 0.06418492780672133 1.8584858846462688e-10 9.730840733058175 0.2531873100275466 EMEHNTVCAAGT(ph)SPVGEIGEEK ddPTM_A459_Selumetinib_30min_R2 7 EMEHNTVCAAGTSPVGEIGEEK 22 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 EMEHNTVCAAGT(0.677)S(0.323)PVGEIGEEK;EMEHNTVCAAGT(0.991)S(0.009)PVGEIGEEK;EMEHNTVCAAGT(0.999)S(0.001)PVGEIGEEK;EMEHNTVCAAGT(0.997)S(0.003)PVGEIGEEK;EMEHNTVCAAGT(0.998)S(0.002)PVGEIGEEK;EMEHNTVCAAGT(0.836)S(0.164)PVGEIGEEK;EMEHNTVCAAGT(0.998)S(0.002)PVGEIGEEK 220.5 5.1426000000000006e-26 530775400.0 1220508.0 986492.0 1427403.0 1838633.0 1913910.0 1279447.0 1229163.0 1289410.0 1241292.0 1573598.0 True False 1152677.0514406376 1062152.7643282725 1335565.4450188805 1588208.0135811653 1673467.51522751 1455679.2105865201 1286321.5150402768 1293161.9696266828 1489585.0845963135 1528164.1370413885 0.7542887727180176 0.6950514925606486 0.8739672739635221 1.0392915100442188 1.095083620053692 0.9525673161030965 0.841743032610795 0.8462192890681998 0.9747546408726969 1.0 20.543368077997634 -5.4345925713895 4.027058855186323 0.9579302649085228 0.7274531859193633 0.6156327667984882 0.07477778298199991 0.17047223675218778 4.972904456521152 0.02310568600360586 0.05048630478969152 3.676270240387423e-06 5.4345925713895 -0.2304770789891596 EMEHNTVCAAGTS(ph)PVGEIGEEK ddPTM_A459_Selumetinib_30min_R1 3 EMEHNTVCAAGTSPVGEIGEEK 22 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 EMEHNTVCAAGT(0.25)S(0.75)PVGEIGEEK;EMEHNTVCAAGT(0.219)S(0.781)PVGEIGEEK;EMEHNTVCAAGT(0.287)S(0.713)PVGEIGEEK 120.61 6.131100000000001e-05 55323300.0 9733.1 9953.400000000001 11274.800000000001 11621.2 12710.1 10206.33 12483.3 9328.17 3043.96 6877.24 True False 9959.862292684218 8788.051300789877 9743.744088043251 9591.775576941543 11560.473699150409 10103.663586806182 11541.674630637512 9080.756629433523 5165.377797957848 7760.000743990396 1.2834872857966502 1.1324807291540067 1.2556370043635798 1.2360534352228942 1.4897516225244214 1.3020183786233264 1.4873290623813111 1.1702004843834537 0.6656414049905974 1.0 12.921841075392944 -8.081331180371958 5.3007215997227535 0.8434682393836703 1.3084738254226282 0.6884817156241632 0.1271798630789151 0.12636807043166765 5.978465867260085 0.0898338576271193 0.03304069208849546 8.292181886189206e-09 8.081331180371958 0.4650055860389579 EMEHNTVCAAGTS(ph)PVGEIGEEK ddPTM_A459_Selumetinib_30min_R2 4 EMEHNTVCAAGTSPVGEIGEEK 22 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 EMEHNTVCAAGT(0.076)S(0.924)PVGEIGEEK;EMEHNTVCAAGT(0.034)S(0.966)PVGEIGEEK;EMEHNTVCAAGT(0.181)S(0.819)PVGEIGEEK;EMEHNTVCAAGT(0.038)S(0.962)PVGEIGEEK 99.873 0.00026872 63400000.0 312416.0 253756.0 362260.0 431506.0 424610.0 302380.0 327902.0 310380.0 260292.0 371491.0 True False 295053.16942033794 273218.26924585743 338952.5859988651 372734.1384106311 371266.6957384379 344030.1002676565 343150.0927254866 311283.154413825 312357.6731661395 360765.08958046563 0.8178539940310072 0.7573301218351904 0.9395382086249909 1.033176848802317 1.029109263787648 0.9536125035483054 0.9511732222331614 0.8628416756616244 0.8658201200381689 1.0 18.460700213457166 -5.3007215079007395 6.912111774967803 0.9552554692472287 0.7876252820859372 0.5810756489289202 0.056678753650935706 0.15287415648967126 22.02936960650203 0.016727815291786505 0.03589398576496051 5.003552858307631e-06 5.3007215079007395 -0.16763018716129152 EMFEDTVEER ddPTM_A459_Selumetinib_30min_R2 2 EMFEDTVEER 10 0 E9PC52;Q16576 E9PC52 RBBP7 Histone-binding protein RBBP7 0 ; 174.86 4.9949e-07 3959600.0 35250.0 38010.0 38914.0 42735.0 46863.0 32879.0 32036.0 33292.0 29607.0 37268.0 False True 33290.946116930376 40925.244778586726 36410.315606359676 36914.419278013054 40975.65097946442 37407.783804154664 33525.7374781297 33388.874208212714 35529.22728869845 36191.97600610729 0.9198432854650608 1.1307822698512155 1.0060328178880187 1.0199614210559782 1.1321750150516763 1.0335932969739539 0.9263306726461227 0.922549081116169 0.9816879653850068 1.0 15.14338225753863 -7.190643063573067 6.143486815880047 0.9513768451297577 1.0468388903174979 0.29946747884294167 0.061386282685059204 0.2544594805295455 17.46629728598866 0.02285425293860978 0.017571611168809124 6.446989107154789e-08 7.190643063573067 0.09546204518774015 EMFPYEAS(ph)TPTGISASCR ddPTM_A459_Selumetinib_30min_R2 1 EMFPYEASTPTGISASCR 18 0 G5E972;P42167;H0YJH7;P42167-2 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 EMFPYEAS(0.5)T(0.5)PTGISASCR 145.79 0.00026061 4346000.0 20783.0 8952.3 18752.0 19850.0 13529.0 11456.0 30578.0 22700.0 22013.0 16159.0 True False 19627.964060940823 9638.912623818525 17545.51673563388 17146.39575684005 11829.366069205438 13033.960012786143 31999.937589157533 22766.053241812693 26416.215094610012 15692.447683875906 1.2507904729934953 0.6142389522650805 1.1180866802354876 1.0926527271114044 0.7538254265687431 0.8305880813086045 2.0391935174037688 1.450764960344903 1.6833712386215471 1.0 13.93778277876271 -7.240002101256807 24.953030045139656 1.5808962101325712 0.9345159069155642 0.4937038027362082 0.2965931129070982 589.0863708389518 685698.4677132177 0.10703368342424818 0.08282731325562714 5.754371531798383e-08 7.240002101256807 -0.646380303217007 EMFPYEAST(ph)PTGISASCR ddPTM_A459_Selumetinib_30min_R1 1 EMFPYEASTPTGISASCR 18 0 G5E972;P42167;H0YJH7;P42167-2 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 EMFPYEAS(0.043)T(0.957)PT(0.001)GISASCR 155.92 5.8168e-05 7136200.0 610.7 1355.9 1073.8 1101.8 1145.7 827.19 1303.4 867.83 346.16 806.33 True False 624.9281217846576 1197.150597659191 927.9838579611921 909.3913133475203 1042.0716372897637 818.8692196284275 1205.0834886266405 844.8123292908795 587.4082374739119 909.8303098193145 0.686862280845275 1.3157954672854721 1.0199526746316934 0.9995174963209553 1.1453472433741092 0.900024115256227 1.3245145557592615 0.9285383440991902 0.6456239489213838 1.0 9.829453686723086 -7.997468110542035 24.999965906658407 0.8109016535964161 1.0646332713919977 0.19117500957475186 0.19397265158556978 99.9368329603752 986782.7649177937 0.09869534641596238 0.04696654707992788 1.0058469178093222e-08 7.997468110542035 0.2537316177955816 EMFPYEAST(ph)PTGISASCR ddPTM_A459_Selumetinib_30min_R2 1 EMFPYEASTPTGISASCR 18 0 G5E972;P42167;H0YJH7;P42167-2 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 EMFPYEAS(0.283)T(0.687)PT(0.029)GISASCR 181.86 2.3753000000000003e-09 4390800.0 39664.0 17147.0 46776.0 43798.0 22890.0 22959.0 59486.0 44261.0 44403.0 32335.0 True False 37459.6336675724 18462.11976370499 43766.483085858075 37832.63684423581 20014.35356080363 26121.393848948774 62252.21686927283 44389.79218219702 53284.84072348014 31401.404533580513 1.1929286037990194 0.5879392988285504 1.3937746968946694 1.2048071545264087 0.6373712850774039 0.8318543147015822 1.9824660009300095 1.4136244171730215 1.6968935471181739 1.0 14.938541469504372 -7.242821647209261 24.792857869337993 1.5577147295411182 0.9713599091269259 0.39647590574599345 0.33039952609018525 703.7376961017907 937154.5141541148 0.12381002753058176 0.0957267363007094 5.7171337541635656e-08 7.242821647209261 -0.5863548204141923 EMLAS(ph)DDEEDVSSK ddPTM_A459_Selumetinib_30min_R1 1 EMLASDDEEDVSSK 14 0 E7EUA0;Q0ZGT2-2;Q0ZGT2;E7ETM8;Q0ZGT2-4;Q0ZGT2-3 E7EUA0 NEXN Nexilin 1 EMLAS(1)DDEEDVSSK 175.66 6.8412e-05 16649000.0 5058.3 5386.9 3616.9 3292.9 4354.4 4347.0 4754.2 4262.9 2759.4 4776.8 True False 5176.148548261556 4756.199243698131 3125.7448462095676 2717.8568303884977 3960.545288831762 4303.273126760206 4395.586866371623 4149.834044149299 4682.500261397948 5389.948809972222 0.960333526486355 0.8824201140646163 0.5799210635222483 0.5042453882604693 0.7348020228882606 0.7983884965286681 0.8155155125479339 0.7699208638997604 0.8687467036300257 1.0 12.396055855979402 -8.537857369420884 0.7968864272446224 0.9993196837686511 0.7328928312370449 0.27876887703940545 0.12533201850731013 1.0376059249518965 1.4740728482491787 0.13615957441808846 0.050141050271167595 2.898295286785736e-09 8.537857369420884 -0.26642685253160625 EMLAS(ph)DDEEDVSSK ddPTM_A459_Selumetinib_30min_R2 5 EMLASDDEEDVSSK 14 0 E7EUA0;Q0ZGT2-2;Q0ZGT2;E7ETM8;Q0ZGT2-4;Q0ZGT2-3 E7EUA0 NEXN Nexilin 1 EMLAS(1)DDEEDVSSK;EMLAS(1)DDEEDVSSK;EMLAS(1)DDEEDVSSK;EMLAS(1)DDEEDVSSK;EMLAS(1)DDEEDVSSK 227.91 2.2345e-21 47580400.0 136907.0 122559.0 132564.0 149197.0 153892.0 132669.0 154156.0 141881.0 135895.0 129152.0 True False 129298.25702214443 131958.8812107029 124034.97656476981 128876.11122081922 134558.71114806444 150942.9505007267 161324.5594543188 142293.85022033605 163077.79722355117 125423.04618280476 1.030897119447183 1.0521103196486883 0.9889328982170323 1.0275313440640057 1.0728388062903877 1.2034706148081156 1.286243352909699 1.1345111967137365 1.3002219463388285 1.0 16.93644293867549 -6.655101279407138 3.5153316321055317 1.2001581930624003 1.026377087634226 0.470890562562821 0.08005699306321433 0.18666682601011897 4.4838025508343256 0.026077662876770952 0.025759461807598614 2.2125786662383648e-07 6.655101279407138 -0.17378110542817438 EMLAS(ph)DDEEDVSSKVEK ddPTM_A459_Selumetinib_30min_R2 2 EMLASDDEEDVSSKVEK 17 1 E7EUA0;Q0ZGT2-2;Q0ZGT2;E7ETM8;Q0ZGT2-4;Q0ZGT2-3 E7EUA0 NEXN Nexilin 1 EMLAS(1)DDEEDVSSKVEK;EMLAS(1)DDEEDVSSKVEK 85.23100000000002 0.006510800000000001 22623100.0 70272.0 90771.0 86577.0 80448.0 88399.0 58235.0 53979.0 51898.0 41126.0 95621.0 True False 66366.56356110435 97732.84382523259 81006.73007791014 69490.84361945928 77293.52732291304 66256.3426453039 56489.13045735931 52049.01458782362 49352.34915644993 92860.17327680532 0.7146935141212087 1.0524732011203815 0.8723517006202276 0.7483385090432171 0.8323646682470651 0.713506558380001 0.6083246289986108 0.5605095570161343 0.5314694924091553 1.0 16.502772352521163 -6.6326516566529286 1.310136251185713 0.6394322140744138 0.8771363790636783 0.2105241643896525 0.14874831085675255 0.5243314930972967 1.8839418648544848 0.06534814335728502 0.06627047819408796 2.3299593459308114e-07 6.6326516566529286 0.2377041649892645 EMLASDDEEDVSS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 EMLASDDEEDVSSK 14 0 E7EUA0;Q0ZGT2-2;Q0ZGT2;E7ETM8;Q0ZGT2-4;Q0ZGT2-3 E7EUA0 NEXN Nexilin 1 EMLAS(0.189)DDEEDVS(0.356)S(0.455)K 107.65 0.0051384 15106000.0 753.99 849.76 624.27 873.66 446.75 666.28 651.05 727.92 297.69 673.28 True False 771.556499990853 750.2697041572935 539.4975628696527 721.0916816293288 406.3415413801187 659.5778281338372 601.9407743366381 708.6131969826076 505.1581875826467 759.7020463025652 1.015604082871677 0.987584155931686 0.7101436220888998 0.94917696370419 0.5348696154732823 0.8682059385570594 0.7923379662675072 0.932751465434897 0.6649425127143309 1.0 9.569289897008446 -5.178635403554509 6.93469903232944 0.801425508710021 1.0057141380705024 0.250909955386189 0.1346709477141375 0.3280895711439223 23.376529500371863 0.03206817827053589 0.086483491221147 6.627726773782572e-06 5.178635403554509 0.2042886293604813 EMLMEDVGS(ph)EEEQEEEDEAPFQEK ddPTM_A459_Selumetinib_30min_R1 1 EMLMEDVGSEEEQEEEDEAPFQEK 24 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EMLMEDVGS(1)EEEQEEEDEAPFQEK 99.396 4.4586e-06 3629300.0 1818.9 2004.0 1182.8 1213.6 1490.3 1102.0 2345.4 2332.8 1113.2 2202.0 True False 1861.2768310367028 1769.370748365675 1022.1822566553338 1001.6675420934382 1355.5026281338346 1090.9148805359437 2168.4845897076275 2270.926565997675 1889.0190950888577 2484.6481492963553 0.7491108274480677 0.7121212509975529 0.41139919829083754 0.4031426109073461 0.5455511391090561 0.4390621186524488 0.8727531865313548 0.9139831596038234 0.7602762973195308 1.0 11.278825851055238 -7.273274286559615 23.74253260490682 0.8795851647534125 0.5387898057200116 0.6549890434270745 0.12200935642850888 265.4725311515413 532572.8838075909 0.05465718822587234 0.03722470769562532 5.329981645033533e-08 7.273274286559615 -0.34079535903340097 EMLMEDVGS(ph)EEEQEEEDEAPFQEK ddPTM_A459_Selumetinib_30min_R2 1 EMLMEDVGSEEEQEEEDEAPFQEK 24 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 EMLMEDVGS(1)EEEQEEEDEAPFQEK 75.018 0.00028829 1847300.0 12136.0 7894.5 12098.0 11752.0 14014.0 13523.0 19847.0 19522.0 15762.0 9148.9 True False 11461.529704257217 8499.982765181612 11319.627851306459 10151.357326669236 12253.43603325043 15385.670500428345 20769.92482608443 19578.805787958932 18914.840427076877 8884.747485303065 1.290023123697843 0.9566937922818941 1.2740517240395537 1.1425600269969818 1.3791541125417202 1.731694741564569 2.337705698495262 2.2036423455304406 2.128911424704568 1.0 13.117115058453699 -6.781059487909855 2.4561846928130344 2.0189491928179297 1.1669696284142517 0.4693504313727975 0.3575391673958092 0.21348395752428584 2.6404341425747995 0.13010732626270743 0.11890847341701442 1.65554317829774e-07 6.781059487909855 -0.8519795644036781 EMPQDLRS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 EMPQDLRSPAR 11 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 EMPQDLRS(1)PAR;EMPQDLRS(1)PAR 84.734 0.019724 81239000.0 6728.5 7079.5 6987.1 7255.7 7412.4 5797.4 6770.6 7457.700000000001 3840.8 5400.2 True False 6885.26095861809 6250.6288488297405 6038.290197393035 5988.628201357418 6741.949728765512 5739.083419618036 6259.88819095867 7259.8975699763605 6517.5570790669135 6093.368272402442 1.1299597613034846 1.0258084805311292 0.990960980438543 0.9828108090037158 1.1064405477181758 0.9418573050329154 1.0273280575064558 1.1914424412614715 1.0696148316827774 1.0 12.573024221589247 -7.585508894726636 24.999994893695483 1.1001946809541985 1.0253622003405403 0.11980976187344261 0.06839732081931543 106.21387931712957 42395.453632496836 0.031152999232847835 0.017986193946487664 2.5971145497049334e-08 7.585508894726636 -0.07483248061365821 EMPQDLRS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 EMPQDLRSPAR 11 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 EMPQDLRS(1)PAR 65.842 0.04364 62055000.0 40378.0 50276.0 48724.0 57183.0 56384.0 37852.0 35326.0 36183.0 27340.0 62474.0 True False 38133.95240594086 54132.00753718042 45589.15088668009 49394.5767538229 49300.537840644516 43065.76941375535 36968.72899714103 36288.28653958187 32808.76394342607 60670.213293054236 0.6285448877811441 0.8922336777638734 0.7514255911129178 0.8141487242715493 0.8125987229105165 0.7098338225009287 0.6093390313063783 0.5981236025048934 0.540772187250282 1.0 15.88870076288815 -6.9610941079178446 4.51440143402413 0.653763036599267 0.7856677098517731 0.07888961633059366 0.13288731454312552 0.3469694030936505 16.075954458015545 0.0460268871969252 0.039379334849434115 1.0937193409200618e-07 6.9610941079178446 0.1319046732525061 EMPSVFQNVLGSAVLS(ph)PAHK ddPTM_A459_Selumetinib_30min_R1 2 EMPSVFQNVLGSAVLSPAHK 20 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 EMPSVFQNVLGSAVLS(1)PAHK;EMPSVFQNVLGS(0.004)AVLS(0.996)PAHK 171.91 8.7442e-10 12706900.0 4019.3999999999996 5672.7 3454.8 3606.9 4059.8 3487.4 5205.5 4693.5 2210.5 3993.2 True False 4113.04419960906 5008.537646833318 2985.6571358580045 2977.0226248985027 3692.5918068159062 3452.3199223058523 4812.844944027908 4569.013133363378 3751.057051467768 4505.766117061857 0.9128401458820316 1.1115840273794129 0.6626302960005628 0.6607139712879228 0.8195258499621793 0.7662004268781396 1.0681524115961645 1.014036906190498 0.8325015000809178 1.0 12.137556713523441 -7.2539155692772175 24.918212295854488 0.9798424478946691 0.8206790121356039 0.24827732300477223 0.13331934056677525 882.7535065189667 2923608.5344606284 0.05621514380874238 0.04268682940321719 5.572940813437164e-08 7.2539155692772175 -0.15916343575906522 EMQPTHPIR ddPTM_A459_Selumetinib_30min_R1 3 EMQPTHPIR 9 0 E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P27348;P31946-2;P31946;P63104-2 E7EX29;P27348;P31946-2;P63104-2 YWHAZ;YWHAQ;YWHAB 14-3-3 protein zeta/delta;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ;; 151.83 0.0016468 28143700.0 15119.7 17770.5 15165.199999999999 17365.1 13784.3 14277.5 14140.300000000001 11709.3 8680.8 11074.7 False True 15471.95959218519 15689.921598718689 13105.849136480794 14332.611268298255 12537.512498815819 14133.88131293278 13073.685786579154 11398.731326833233 14730.683579453254 12496.245621713138 1.2381286396372948 1.2555708389291185 1.048782933148211 1.1469533892159016 1.0033023420275107 1.1310502162644858 1.0462090921022447 0.9121724773900975 1.178808741871848 1.0 13.60920709551593 EMS(ph)PFS(ph)S(ph)SS(ph)T(ph)THLFSK ddPTM_A459_Selumetinib_30min_R2 1 EMSPFSSSSTTHLFSK 16 0 Q8N8D9 Q8N8D9 C5orf56 Uncharacterized protein C5orf56 5 EMS(0.873)PFS(0.785)S(0.813)S(0.509)S(0.921)T(0.424)T(0.371)HLFS(0.304)K 54.253 0.047946 31775000.0 23381.0 14128.0 28276.0 27147.0 27287.0 21276.0 27623.0 21435.0 23700.0 19794.0 True False 22081.577621558827 15211.572171320006 26456.752944581025 23449.531768812936 23858.963111124907 24206.575875701652 28907.524233936103 21497.372301244737 28440.66223332837 19222.495789011686 1.1487362444465459 0.7913422033373795 1.376343282109325 1.2199004763063903 1.2412000695957288 1.2592837132803045 1.50383823990539 1.1183444926820303 1.4795509670282327 1.0 14.23050804285522 -5.271205435341568 24.99728634710729 1.2834982437112814 0.970039215532774 0.3511095058777295 0.16539016137652218 580.7570676745783 1486513.063555485 0.039699002851267505 0.08428867087958816 5.355432682939743e-06 5.271205435341568 -0.31345902817850746 EMS(ph)PSPPAAQDPGGTALVSAR ddPTM_A459_Selumetinib_30min_R2 2 EMSPSPPAAQDPGGTALVSAR 21 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 EMS(0.975)PS(0.025)PPAAQDPGGTALVSAR;EMS(0.993)PS(0.007)PPAAQDPGGTALVSAR 241.92 1.6375999999999994e-68 4685900.0 22694.0 21600.2 19200.6 24489.0 26108.0 18136.7 18218.7 21181.3 15850.400000000001 21235.3 True False 21432.758331279947 23256.865884410156 17965.25430003263 21153.55595411869 22828.079631518627 20634.865796429687 19065.90564966919 21242.934076247013 19020.92289717924 20622.181713064558 1.0393060554646298 1.1277597204798402 0.871161671931699 1.025767120494215 1.1069672428042174 1.000615069905872 0.9245338788567924 1.0301011974300078 0.9223525988585927 1.0 14.331909349506512 -6.999172825308228 24.997935735463397 0.9704437926884346 1.0322578126312782 0.15887837331897514 0.07042651855828817 57.81078668038478 1747021.0742178545 0.025305265864776525 0.02212855096264942 1.001906455093671e-07 6.999172825308228 0.061814019942843634 EMTDATNEEETEIKEDT(ph)KVPSPK ddPTM_A459_Selumetinib_30min_R1 1 EMTDATNEEETEIKEDTKVPSPK 23 2 Q9HCE3 Q9HCE3 ZNF532 Zinc finger protein 532 1 EMTDATNEEET(0.012)EIKEDT(0.494)KVPS(0.494)PK 63.606 0.007201300000000002 24159000.0 4294.0 5604.0 6444.9 6857.9 3731.2 4439.2 4473.4 4226.0 3948.1 5571.2 True False 4394.041845330474 4947.881074771078 5569.7179793016285 5660.29650372659 3393.713618796862 4394.545678471108 4135.967836444998 4113.912752017394 6699.637342184982 6286.317788083493 0.6989850009905534 0.7870873286346436 0.8860064296876194 0.9004152660650397 0.5398571521837591 0.6990651485678187 0.6579317139017767 0.6544232873202551 1.0657490709243158 1.0 12.617999490254608 -8.266569256370675 24.940868898683295 1.032874583514903 0.7313892323684986 0.5795597674762826 0.10384566740123483 345.0194129325371 1677414.3311263514 0.09850377922352777 0.028509245583393693 5.41290922047269e-09 8.266569256370675 -0.3014853511464043 ENAAAES(ph)GSESSSQEATPEK ddPTM_A459_Selumetinib_30min_R2 1 ENAAAESGSESSSQEATPEK 20 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7ESQ0 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ENAAAES(1)GSESSSQEATPEK 221.51 1.2035e-19 8323200.0 44869.0 36389.0 43358.0 48554.0 48977.0 43223.0 45169.0 53250.0 40963.0 39666.0 True False 42375.36060483826 39179.919290923266 40568.39348462105 41940.8614396782 42824.071400064626 49176.57591067177 47269.448000675504 53404.94868398791 49156.74460184939 38520.73951535502 1.1000661238070657 1.0171123343908153 1.053157182209594 1.0887865074075191 1.1117146747142335 1.2766259560273798 1.2271168361612868 1.3863946890920875 1.2761111344255132 1.0 15.233347779638772 -6.6385300745594265 3.2049789440491385 1.2578354124582194 1.0627655431549052 0.40676455130554634 0.09460644634556259 0.21209430244270613 4.329275495730377 0.0318246946276365 0.03166427469803766 2.2986345250763846e-07 6.6385300745594265 -0.19506986930331416 ENAAAESGSESSS(ph)QEATPEK ddPTM_A459_Selumetinib_30min_R1 1 ENAAAESGSESSSQEATPEK 20 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7ESQ0 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ENAAAES(0.004)GS(0.029)ES(0.222)S(0.222)S(0.523)QEATPEK 211.11 6.6823e-17 4245200.0 2081.3 2321.9 952.84 1110.3 1421.2 1852.9 2260.5 2061.9 1148.0 2093.8 True False 2129.790240495184 2050.050868577974 823.4495615754722 916.4069479122811 1292.6527109332387 1834.261508298592 2089.9886650610083 2007.2117140048902 1948.0721533974204 2362.559625339105 0.9014757628347642 0.8677244995599739 0.3485412824056367 0.3878873312163483 0.5471407777688153 0.7763873929892098 0.8846289603213829 0.8495919817121184 0.8245599952288222 1.0 11.20613502461825 -6.937989300983651 3.9188353614968876 0.873354288257428 0.598811156816854 0.3697081059559346 0.17134351875297774 0.2842856146511125 8.87295709698532 0.07161929633541665 0.061489748814153825 1.1534816739483717e-07 6.937989300983651 -0.27454313144057396 ENAEQGEVDMES(ph)HR ddPTM_A459_Selumetinib_30min_R1 1 ENAEQGEVDMESHR 14 0 P14209-3;P14209 P14209-3 CD99 CD99 antigen 1 ENAEQGEVDMES(1)HR 105.99 0.0037481 4230300.0 2859.4 3304.9 2367.5 1919.3 2441.7 2421.3 2530.7 3041.5 2057.3 2803.9 True False 2926.0184565761424 2917.960771593675 2046.0065037466204 1584.1302847230854 2220.8486661171487 2396.9439203644997 2339.8072615217416 2960.8295398156415 3491.0878407530604 3163.8078772988433 0.9248407520479032 0.9222939207310323 0.6466911339425055 0.500703691930739 0.7019543386475279 0.7576136141398487 0.7395541550770122 0.9358436588581674 1.103444954986849 1.0 11.627446279263006 -7.8939818174461704 2.991640617706698 1.0486834452093714 0.7335018479486681 0.5334029602767122 0.11905823321324788 0.22520733666889947 3.9383219513779664 0.0898635332431995 0.03676308663088281 1.2764922504371708e-08 7.8939818174461704 -0.3151815972607033 ENAEVDGDDDAEEMEAK ddPTM_A459_Selumetinib_30min_R1 1 ENAEVDGDDDAEEMEAK 17 0 P05198 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 328.41 1.770399999999999e-134 11118000.0 2734.1 2699.4 2160.6 2273.7 2440.4 2454.6 2809.0 2239.9 1529.1 2565.5 False True 2797.799210367502 2383.3529930829864 1867.2023873262722 1876.6409776350113 2219.6662508876148 2429.9089525984805 2597.114868461124 2180.490575779405 2594.7710189547 2894.8069150861943 0.9664890586611702 0.8233201947467439 0.6450179380170077 0.6482784630142192 0.766775234410245 0.839402773267912 0.8971634187158882 0.753242146968714 0.8963537448498321 1.0 11.499251407682285 -6.825899927493955 3.9002590224425147 0.866050796650396 0.758726020831885 0.2114298118340191 0.10252521871932857 0.4115290220008852 12.485448392459611 0.03947710508880826 0.03540907658156468 1.4931384270521307e-07 6.825899927493955 -0.10732477581851096 ENAEVDGDDDAEEMEAK ddPTM_A459_Selumetinib_30min_R2 1 ENAEVDGDDDAEEMEAK 17 0 P05198 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 257.16 6.7679e-39 29264000.0 35166.0 29292.0 30963.0 34893.0 34832.0 27466.0 30369.0 33172.0 24705.0 32841.0 False True 33211.61450065174 31538.602211374964 28970.87428996543 30140.513206217634 30456.09275796909 31249.192188476263 31781.218675031883 33268.52502807978 29646.690315374566 31892.79499883464 1.0413516439015549 0.9888942694588976 0.9083830467359171 0.9450571267685685 0.9549521375935208 0.9798198053704013 0.9965015194244708 1.0431360760101271 0.9295732881504382 1.0 14.960942916595927 -7.026727543539978 3.8861228518653794 0.9954822371837262 0.9644176543490123 0.0687043223100835 0.04095061508167618 0.5632883803369183 18.564923097798413 0.016517734503461105 0.013266808294292725 9.403130348783663e-08 7.026727543539978 -0.031064582834713916 ENALSSGTLQEEQRT(ph)PPPGQDTQQFHEK ddPTM_A459_Selumetinib_30min_R1 2 ENALSSGTLQEEQRTPPPGQDTQQFHEK 28 1 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 ENALSSGTLQEEQRT(1)PPPGQDTQQFHEK;ENALSS(0.001)GT(0.001)LQEEQRT(0.998)PPPGQDTQQFHEK 129.68 1.7811e-12 29937000.0 4048.7000000000003 5043.6 4430.9 4766.7 4972.1 4192.7 4704.5 4517.4 2371.52 3654.7 True False 4143.026832601186 4453.092967293972 3829.208117191513 3934.2853270408636 4522.374432895554 4150.525244667014 4349.6357773853215 4397.583877416795 4024.296231032275 4123.816344792638 1.0046584246732533 1.0798475477495812 0.9285593239443986 0.9540398985053965 1.0966478753609374 1.0064767432982564 1.0547598180209548 1.0663869362101583 0.9758669869267984 1.0 12.009764368009039 -6.243061467237173 24.95569249284086 1.0364019361449581 0.9935516101660603 0.14478473791418067 0.04909817684248643 1659.020080070414 2252810.3481433047 0.014749902127064755 0.019002270448864458 5.713977589986723e-07 6.243061467237173 -0.04285032597889782 ENALSSGTLQEEQRT(ph)PPPGQDTQQFHEK ddPTM_A459_Selumetinib_30min_R2 3 ENALSSGTLQEEQRTPPPGQDTQQFHEK 28 1 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 ENALSSGTLQEEQRT(0.999)PPPGQDTQQFHEK;ENALSS(0.001)GT(0.001)LQEEQRT(0.998)PPPGQDTQQFHEK;ENALS(0.041)S(0.032)GT(0.032)LQEEQRT(0.896)PPPGQDTQQFHEK 112.74 1.4813e-10 55034700.0 138418.0 117282.4 150626.0 147542.0 155080.2 104483.9 119179.0 125861.5 94134.1 140268.9 True False 130725.28169115668 126277.58295764567 140934.88714918873 127446.5250758539 135597.63884142172 118875.60881459016 124721.05964870838 126227.73612750685 112963.5503265132 136218.97239462953 0.959670150149441 0.9270190542314222 1.0346201022637074 0.9356004001163536 0.9954387150168202 0.8726802641720476 0.9155924278109262 0.9266531226048467 0.829279125665808 1.0 17.055568128399372 -6.758092670345119 24.999994296400715 0.9046787723326307 0.9696824915973329 0.27855865794997925 0.04935526002635019 109.16694179850847 815481.5778515504 0.01573269318498009 0.015118181848585157 1.7454496667657288e-07 6.758092670345119 0.06500371926470216 ENARS(ph)PSSVTGNALWK ddPTM_A459_Selumetinib_30min_R1 1 ENARSPSSVTGNALWK 16 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 ENARS(0.999)PS(0.001)SVTGNALWK 116.87 0.008954299999999998 8643400.0 869.55 1030.6 1975.1 2249.2 1425.9 1492.5 1204.7 1122.4 750.82 757.99 True False 889.8088231502354 909.9368728870581 1706.8922684477086 1856.4194427130535 1296.9275967630924 1477.4868050815749 1113.828509090465 1092.6303059309805 1274.0867022768737 855.2853999478405 1.0403647989367062 1.0638985219934196 1.9956990596961006 2.1705262861101886 1.5163682167872683 1.7274781086777342 1.3022886970342202 1.2775037502073747 1.4896626346650765 1.0 9.740262102620306 -8.471497727402102 0.7501017323395787 1.0293527524687605 1.5857623489298274 0.16993287362378418 0.3493329574150921 1.3505355356773578 1.7280939604449708 0.37689625752286127 0.14511544718786207 3.3767761565373432e-09 8.471497727402102 0.5564095964610669 ENAS(ph)PAPGTTAEEAMSR ddPTM_A459_Selumetinib_30min_R1 4 ENASPAPGTTAEEAMSR 17 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 ENAS(0.932)PAPGT(0.061)T(0.007)AEEAMSR;ENAS(0.99)PAPGT(0.001)T(0.01)AEEAMSR;ENAS(0.997)PAPGTT(0.003)AEEAMSR;ENAS(1)PAPGTTAEEAMSR 219.96 6.612000000000001e-12 128240500.0 12917.3 17246.7 9982.7 10913.8 12407.8 11713.6 15450.6 14008.000000000002 6895.5599999999995 12872.6 True False 13218.24795730958 15227.448346226689 8627.104171045994 9007.90970739895 11285.516680775012 11595.771819097845 14285.148802650569 13636.462335603323 11701.261688223964 14524.92359974216 0.9100390695028664 1.0483668462460622 0.593951776186908 0.620169162718271 0.7769759753486998 0.7983361660713787 0.9834921818731048 0.9388319492327926 0.805598845864613 1.0 13.826242954706759 -7.1823530671135645 6.722284242535051 0.9265677719047064 0.784774438901775 0.21502668337804653 0.13125255333771102 0.451815990311363 32.3413817022959 0.055532639762269416 0.042853496307283113 6.571234004579006e-08 7.1823530671135645 -0.1417933330029314 ENAS(ph)PAPGTTAEEAMSR ddPTM_A459_Selumetinib_30min_R2 6 ENASPAPGTTAEEAMSR 17 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 ENAS(0.778)PAPGT(0.075)T(0.147)AEEAMSR;ENAS(0.934)PAPGT(0.033)T(0.033)AEEAMSR;ENAS(0.934)PAPGT(0.003)T(0.063)AEEAMSR;ENAS(0.97)PAPGT(0.005)T(0.026)AEEAMSR;ENAS(0.892)PAPGT(0.007)T(0.101)AEEAMSR;ENAS(0.997)PAPGTT(0.003)AEEAMSR 122.97 0.0014007 278225000.0 169887.0 127679.2 165827.8 181235.0 177863.0 149476.2 171151.0 177819.1 159695.8 136139.5 True False 160445.36065154482 137471.7840866649 155158.61988765697 156550.48035218648 155518.25982460528 170065.18974015568 179109.8606292727 178336.52414146307 191639.42227346628 132208.7989020994 1.2135755107370318 1.039808130988791 1.1735876974614368 1.1841154420297857 1.1763079395325764 1.2863379075555246 1.354749926757171 1.3489005695719334 1.4495209385827281 1.0 17.012458670268785 -6.74486652391978 2.4628177925807537 1.3188743129138152 1.1473982255474153 0.21935507956645794 0.1178930875093414 0.34932881273214583 4.344667535125603 0.04241197013338036 0.03963818826902356 1.799423865141948e-07 6.74486652391978 -0.17147608736639985 ENASPAPGTT(ph)AEEAMSR ddPTM_A459_Selumetinib_30min_R2 3 ENASPAPGTTAEEAMSR 17 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 ENAS(0.001)PAPGT(0.005)T(0.994)AEEAMSR;ENAS(0.003)PAPGT(0.042)T(0.955)AEEAMSR;ENAS(0.127)PAPGT(0.047)T(0.825)AEEAMSR 234.51 1.4037e-16 203376900.0 358350.0 275213.0 377686.0 416109.0 422359.0 329329.0 375983.0 406217.0 362776.0 307475.0 True False 338434.3415887091 296320.95215072855 353386.0939534242 359434.2363719379 369298.4864826328 374691.0803989914 393466.95449618076 407399.0242171551 435341.33680835174 298597.3978340089 1.1334135663728913 0.9923762038792252 1.183486850578224 1.2037420251456725 1.2367773100552164 1.254837058584426 1.3177172920807236 1.3643756682823784 1.4579542218594923 1.0 18.18784206740984 -5.876765690481623 0.9552627044777838 1.3062113464622633 1.0541739762835036 0.2999828915597501 0.11758465594146783 0.687037576463855 1.224450667677665 0.04763381182344033 0.12450200829760383 1.3281108036305878e-06 5.876765690481623 -0.2520373701787597 ENCQAELS(ph)PAASK ddPTM_A459_Selumetinib_30min_R2 2 ENCQAELSPAASK 13 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 ENCQAELS(0.982)PAAS(0.018)K;ENCQAELS(0.999)PAAS(0.001)K 193.32 4.098e-21 0.0 26324.0 16776.0 19340.7 23757.0 25923.0 28070.0 30892.0 32784.0 31253.0 25790.0 True False 24861.017463321285 18062.66525665801 18096.340418561977 20521.255616889124 22666.320985439626 31936.387705910187 32328.539211336705 32879.39601231662 37504.473281781065 25045.375689532735 0.9926390313127346 0.7211976167004345 0.7225421827521245 0.8193630581259603 0.905010220905275 1.2751410919843948 1.2907987331508801 1.3127930848351368 1.4974609982574703 1.0 14.612256632245709 -6.706061432696286 3.106300755346021 1.3027118043533616 0.8044933030461854 0.733019541741368 0.1340601913384474 0.1202641736363703 2.361552216836334 0.046613077026879265 0.04479572969643158 1.9676079439856065e-07 6.706061432696286 -0.49821850130717626 ENDPLRT(ph)PEALPEEK ddPTM_A459_Selumetinib_30min_R1 1 ENDPLRTPEALPEEK 15 1 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 ENDPLRT(1)PEALPEEK 91.518 0.020006 9183000.0 5584.8 9116.0 7585.3 8887.2 6758.9 7359.1 7139.5 6863.0 3312.1 6099.8 True False 5714.914973870893 8048.694482086573 6555.257923070433 7335.21735340541 6147.558688380715 7285.074135528188 6600.9617669555755 6680.970945834214 5620.391793787102 6882.768747083517 0.8303220962192741 1.1693977784008944 0.9524158320513293 1.0657364242425857 0.8931810604541467 1.058451097694535 0.9590561603210404 0.9706807233157714 0.8165887886569877 1.0 12.748773322576278 -8.023596235261476 18.86012122220432 0.9034072605644846 0.9948074571656387 0.09448310269965732 0.09843240307325057 68.55001800180327 54783.61380086323 0.05947755132419984 0.023062625676193885 9.471172896446882e-09 8.023596235261476 0.09140019660115406 ENDPLRT(ph)PEALPEEK ddPTM_A459_Selumetinib_30min_R2 2 ENDPLRTPEALPEEK 15 1 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 ENDPLRT(1)PEALPEEK;ENDPLRT(1)PEALPEEK 119.68 0.0026022 11887700.0 104852.0 103303.0 103611.0 103835.0 106063.0 80542.0 86481.0 95212.0 71581.0 90206.0 True False 99024.74559581222 111226.00792850187 96944.7810631274 89692.49387463398 92738.4177247495 91635.9294125193 90502.5378588506 95489.05115680478 85899.20014024805 87601.51839666514 1.1303998767169994 1.2696812790945424 1.1066564009102604 1.023869169350476 1.0586393868748274 1.046054122002613 1.0331160865163258 1.0900387676435517 0.9805674800211923 1.0 16.418668255818297 -5.5032967127618 4.581074652384809 1.0395128097758333 1.199790736896645 0.7083332748874983 0.04259401438186823 0.09381897915965114 4.9508021806418885 0.010621973367506083 0.021395388526483747 3.138363811075375e-06 5.5032967127618 0.16027792712081168 ENDTVTIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ENDTVTISPK 10 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 ENDT(0.001)VT(0.039)IS(0.96)PK 91.202 0.028363 3795400.0 2149.8 2305.5 1946.4 1925.9 1979.6 2004.2 2120.6 2111.4 901.1 1963.1 True False 2199.8861572173855 2035.5709882021283 1682.0895708098947 1589.5777186204286 1800.5455295267675 1984.0395676680018 1960.641434695146 2055.398813206228 1529.1008862599433 2215.0830072132953 0.9931393767428028 0.9189592360978817 0.7593799263198097 0.7176154182231802 0.8128569104017278 0.8956953582358254 0.8851322629041104 0.9279105146456975 0.6903131310567192 1.0 11.113145047483528 -9.249952033479454 15.601479947394132 1.0000041443963645 0.8447220740821616 0.19999655662259874 0.09326699424930053 0.0 0.0 0.09421851445732429 0.022851346293901925 5.624034375299745e-10 9.249952033479454 -0.15528207031420294 ENDTVTIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ENDTVTISPK 10 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 ENDTVT(0.002)IS(0.997)PK 93.243 0.025494 11011000.0 67110.0 54776.0 50422.0 54346.0 48342.0 45587.0 66903.0 57050.0 42911.0 47748.0 True False 63380.29486261554 58977.143067399826 47177.90341532269 46943.98104792088 42268.84577703665 51866.19545241636 70014.12206577953 57216.00605486407 51494.399033517046 46369.391175797195 1.3668563087733034 1.2718981546210884 1.0174363350267042 1.0123915768043037 0.9115678404485749 1.1185438095527176 1.5099210986044573 1.2339175607879953 1.1105256663450627 1.0 15.500885163984027 -7.037148337059025 24.94639770431217 1.2446768133168655 1.1036142738785428 0.056908461642639296 0.17279451648078023 1272.3143667522345 854399.2252365411 0.06975660010347513 0.054047929602844984 9.180189855562968e-08 7.037148337059025 -0.1410625394383227 ENEPQQMVSPSNS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 ENEPQQMVSPSNSLR 15 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 ENEPQQMVS(0.004)PS(0.006)NS(0.99)LR 85.988 0.020151 9966800.0 11042.0 8032.7 11092.0 12307.0 14175.0 11370.0 13784.0 10296.0 12426.0 10078.0 True False 10428.329844628226 8648.782260798574 10378.352796056468 10630.765369240826 12394.20977389216 12936.114293416415 14424.983312477832 10325.959655405439 14911.547211448878 9787.021954211365 1.0655263565788677 0.883699076313709 1.0604198953074437 1.0862104344893595 1.266392354270639 1.321762059382118 1.4738889296422544 1.0550665671044264 1.5236041444693424 1.0 13.256654220538886 -6.083691702650429 1.9298172607096649 1.2927404576841957 0.9849933307529819 0.37991654877810743 0.15819689482577098 0.31956000159673054 2.363009909897853 0.04920467297383935 0.07378002970821117 8.247233626078883e-07 6.083691702650429 -0.30774712693121375 ENESLTHSTDR ddPTM_A459_Selumetinib_30min_R2 1 ENESLTHSTDR 11 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7;H0YA05 Q8WX93 PALLD Palladin 0 123.95 0.005218899999999999 1166500.0 7830.7 8405.4 12543.0 17098.0 19735.0 14409.0 9337.6 10891.0 10819.0 17941.0 False True 7395.50104277579 9050.067152379195 11735.997035785815 14769.222904304854 17255.7128668615 16393.708958121115 9771.816902103388 10922.69100689789 12983.10230811729 17422.99671368387 0.42446779760725245 0.5194322940594571 0.6735923348116379 0.8476855702271489 0.9903986754074867 0.9409236096133587 0.5608574152131182 0.6269123036865009 0.7451704503807013 1.0 14.088705164918315 -5.328710909618028 2.2793283801174127 0.8010980785693244 0.44422547649859934 0.49437913925472576 0.13848471809311902 0.3124119637305651 3.0610211963512786 0.043111556809291234 0.13634455497082196 4.691255541007381e-06 5.328710909618028 -0.356872602070725 ENFDSAY(ph)T(ph)ELNEIGRGRFS(ph)IVK ddPTM_A459_Selumetinib_30min_R2 1 ENFDSAYTELNEIGRGRFSIVK 22 2 H7BXZ5;O60229-6;O60229-4;O60229 H7BXZ5 KALRN Kalirin 3 ENFDS(0.58)AY(0.732)T(0.688)ELNEIGRGRFS(1)IVK 52.824 0.027856 3611000.0 24692.0 22850.0 18111.0 19606.0 17149.0 11432.0 14929.0 11709.0 8759.5 19484.0 True False 23319.717489907664 24602.521525669737 16945.757977765836 16935.62897776353 14994.589305994825 13006.65423063645 15623.228081252293 11743.071251470703 10511.644760879324 18921.446294488414 1.2324489960738578 1.3002452953522983 0.8955847092249987 0.8950493907379939 0.792465283711561 0.6874027507308006 0.8256888949235951 0.6206222858815669 0.5555412941103365 1.0 14.207734747409582 -5.4274092760880315 1.0739589847526245 0.7232920609076724 1.3534524899656282 0.7057124171593954 0.12558789471712326 0.38845007324700875 0.7073944874518399 0.04282739536301195 0.2189720790857738 3.7375819513774445e-06 5.4274092760880315 0.6301604290579558 ENFS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 ENFSPER 7 0 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 ENFS(1)PER 86.882 0.034321 109460000.0 2760.2 3891.7 3085.8 3877.2 3511.4 3593.5 3449.3 3202.5 1964.7 2893.0 True False 2824.50728958574 3436.0579547977554 2666.7653090860913 3200.1198040579093 3193.794489988022 3557.3526526369437 3189.1165239526395 3117.5592968139367 3333.952403989469 3264.344730206338 0.8652601128334886 1.0526026626423624 0.8169374038254611 0.9803253236234124 0.9783876256801295 1.0897601039863472 0.9769545766543647 0.9550337217653102 1.0213236283346616 1.0 11.67257770542047 -5.982592889499211 24.997041733053628 1.0020382153139313 0.9211888147166026 0.28072103177156604 0.06537212613607712 342.4288732181106 491732.8175306951 0.01781462978110766 0.026417777169876082 1.0408954508730007e-06 5.982592889499211 -0.0808494005973287 ENGEEGCHQNGLALPVVEEGEVLSHS(ph)LEAEHR ddPTM_A459_Selumetinib_30min_R2 1 ENGEEGCHQNGLALPVVEEGEVLSHSLEAEHR 32 0 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 ENGEEGCHQNGLALPVVEEGEVLS(0.5)HS(0.5)LEAEHR 78.043 6.5735e-06 3515300.0 6023.7 6471.5 7568.7 5548.1 8622.1 5228.9 6163.0 6093.2 6315.0 6424.1 True False 5688.926868781661 6967.843240847778 7081.7380821774805 4792.439208993665 7538.914715448011 5949.133511771774 6449.591711752824 6110.930203216437 7578.176455842561 6238.619541183687 0.9118887329523336 1.1168886313470772 1.1351450485845502 0.7681890484516337 1.2084267466032417 0.9535977426575066 1.033817123992964 0.9795324370841465 1.2147200844378967 1.0 12.607011114804568 -8.225849250098557 24.964639544852616 1.1073603782638344 1.0179506951915223 0.07913307453528418 0.12741889983234084 1361.002768978118 954676.1804193143 0.0810729429965406 0.030640169005789416 5.944984818335181e-09 8.225849250098557 -0.08940968307231212 ENGSFS(ph)GK ddPTM_A459_Selumetinib_30min_R2 1 ENGSFSGK 8 0 H0Y897;H7C556;D3YTG3;Q7Z7G0-2;Q7Z7G0-3;Q7Z7G0-4;Q7Z7G0 H0Y897 ABI3BP Target of Nesh-SH3 1 ENGS(0.031)FS(0.969)GK 87.184 0.021714 2864500.0 18088.0 11769.0 33658.0 23352.0 43462.0 30585.0 13391.0 14903.0 51993.0 18692.0 True False 17082.741372001048 12671.644456700544 31492.48092405958 20171.4173155531 38001.9150047902 34797.806127013304 14013.708033763116 14946.36526267554 62393.05280579924 18152.31339235153 0.9410779222883433 0.6980732528582134 1.7349017859800129 1.1112312177274504 2.0935025846789475 1.91699015849271 0.7720067261326474 0.823386250535603 3.4371956597051994 1.0 14.147865801433932 -5.260157696140605 24.99985224875069 1.585170011897495 0.8195755320957125 0.1498076357106397 0.7522660384040556 212.98300417324447 4154219.894942301 0.1903946766062938 0.4502783634346671 5.493413669634849e-06 5.260157696140605 -0.7655944798017824 ENGSGHEASLQLRPPPEPS(ph)TPVSGQDDLIQHQDMR ddPTM_A459_Selumetinib_30min_R2 1 ENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMR 35 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 ENGSGHEAS(0.003)LQLRPPPEPS(0.485)T(0.485)PVS(0.026)GQDDLIQHQDMR 56.483 0.00028992 3865400.0 4849.1 4207.6 6680.4 6779.8 7712.9 5424.9 6444.3 4579.8 5732.9 6543.1 True False 4579.606434485309 4530.30939043361 6250.5903370695705 5856.379544192654 6743.936547799141 6172.130732660921 6743.972719138195 4593.126459773293 6879.6401906096335 6354.183701984554 0.7207230148311569 0.712964812304481 0.9836968256233087 0.9216572606113945 1.0613379883387473 0.9713491177054302 1.061343680862091 0.722850750811431 1.0826945699509707 1.0 12.633491084205321 -5.260049439456023 24.858522813230433 0.9697617679401406 0.7168438848517703 0.5321672620346227 0.09692652705624487 81.6691854416034 1460578.9880352553 0.02409988535013383 0.05703477119530558 5.494783184796109e-06 5.260049439456023 -0.25291788308837027 ENIKPNET(ph)SPSFSK ddPTM_A459_Selumetinib_30min_R2 2 ENIKPNETSPSFSK 14 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 ENIKPNET(0.759)S(0.227)PS(0.01)FS(0.004)K;ENIKPNET(0.902)S(0.097)PSFSK 175.26 0.00073315 40466000.0 113724.0 105624.0 119467.0 123796.0 127492.0 116508.0 132118.0 128578.0 116983.0 112242.0 True False 107403.67535324224 113725.02116531029 111780.6232858347 106934.77123998867 111475.3151670589 132555.9194456782 138261.74878685057 128952.14069276628 140382.86877812038 109001.28182026118 0.9853432322965401 1.0433365485814963 1.0254982457009685 0.9810414102865312 1.0226972867243644 1.2160950516550595 1.2684414942462672 1.1830332500621714 1.2879010818387089 1.0 16.73398557517168 -6.749556831302566 7.900951975287024 1.2075609141648262 1.0120281802202635 0.5822185457363421 0.07539682511651438 0.0916450485784237 34.51094733249893 0.02371859752465536 0.02280989665291752 1.7800949523265016e-07 6.749556831302566 -0.19553273394456272 ENIKPNETS(ph)PSFSK ddPTM_A459_Selumetinib_30min_R1 2 ENIKPNETSPSFSK 14 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 ENIKPNET(0.143)S(0.701)PS(0.143)FS(0.014)K;ENIKPNET(0.395)S(0.6)PS(0.005)FSK 178.01 0.00033719 61576000.0 8551.400000000001 11256.0 6056.099999999999 7164.7 7603.2 7457.8 9145.8 8972.7 4421.5 8473.7 True False 8750.630981872151 9938.142287227573 5233.714883776097 5913.519643075853 6915.491902453984 7382.781303140616 8455.924942674172 8734.714848562815 7502.962566416984 9561.381935827667 0.9152056722138112 1.0394043825389025 0.5473805898459853 0.6184795966488037 0.7232732620522971 0.7721458417508071 0.8843831361854491 0.9135410453412357 0.7847152866368058 1.0 13.223003435073112 -7.252510230003552 5.064869834226763 0.8893421880909252 0.7618979954073023 0.1646972830512129 0.1387036762614289 0.39454892687694115 32.08688541017336 0.061986220066645246 0.044775269059556144 5.591003575528727e-08 7.252510230003552 -0.12744419268362295 ENIKPNETS(ph)PSFSK ddPTM_A459_Selumetinib_30min_R2 1 ENIKPNETSPSFSK 14 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 ENIKPNET(0.199)S(0.8)PS(0.001)FSK 122.63 0.008289200000000002 21830000.0 40718.0 31001.0 38597.0 40898.0 42302.0 33828.0 40177.0 41967.0 40355.0 35240.0 True False 38455.05656706869 33378.67701607387 36113.71104123615 35327.62184701481 36987.644575321785 38487.49993999035 42045.310109215185 42089.11702198917 48427.127612909986 34222.52963548407 1.123676624044649 0.9753421904108678 1.0552612979196951 1.032291365463087 1.0807980873795686 1.1246246361661147 1.2285856877634191 1.2298657483913327 1.4150656929433323 1.0 15.062658783376909 -7.0341256284686375 1.7778536248433743 1.2422986487501333 1.0440794122539996 0.3681430425821083 0.1003197569307835 0.33299449750937987 2.1089927345416877 0.0450329657584115 0.033435126726499634 9.244307249606945e-08 7.0341256284686375 -0.1982192364961337 ENIKPNETSPS(ph)FSK ddPTM_A459_Selumetinib_30min_R2 1 ENIKPNETSPSFSK 14 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 ENIKPNET(0.131)S(0.016)PS(0.801)FS(0.052)K 85.36200000000002 0.013582 19656000.0 74754.0 69501.0 75538.0 86864.0 72477.0 74547.0 85121.0 82306.0 69424.0 67916.0 True False 70599.47194397206 74831.50321906211 70677.96731955589 75032.97335124218 63371.79130739908 84815.17257971088 89079.29516406171 82545.49683350815 83310.73986863244 65955.08861304028 1.0704173617016948 1.1345827106396584 1.0716074954310928 1.1376373670189728 0.9608324791920536 1.285953432301836 1.350605344292562 1.2515409890176041 1.2631434756674818 1.0 16.009196351135287 -6.781172358909454 24.999591904624236 1.2534922957851338 1.081614413246801 0.3748586313345389 0.0977742392219423 226.87671982288663 287426.8225251451 0.032640481888692216 0.028824856696251077 1.6551129666765013e-07 6.781172358909454 -0.1718778825383327 ENLPENVTASES(ph)DAEVER ddPTM_A459_Selumetinib_30min_R1 4 ENLPENVTASESDAEVER 18 0 Q9NX02;A0A0G2JMG8;A0A0G2JLX3;J3KN39;A0A0G2JNC8;A0A0G2JP37;A0A0G2JPQ2;A0A0G2JPB6;A0A0G2JLQ8;Q9NX02-5;Q9NX02-2;Q9NX02-4;Q9NX02-3;K7EMK2 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 1 ENLPENVTAS(0.002)ES(0.998)DAEVER;ENLPENVTASES(1)DAEVER;ENLPENVTASES(1)DAEVER;ENLPENVTAS(0.002)ES(0.998)DAEVER 335.12 1.1196999999999992e-144 19834000.0 9683.18 11773.970000000001 11401.35 12333.25 11169.44 9669.84 10629.26 9931.779999999999 5528.639999999999 8862.65 True False 9908.779253811632 10395.46811882985 9853.109293132653 10179.479411275457 10159.166124124795 9572.570189112243 9827.486360533685 9668.356931431917 9381.698284110724 10000.257457021497 0.9908524151900074 1.0395200487094323 0.9852855624446423 1.01792173401777 1.0158904575993415 0.9572323742916278 0.9827233351510862 0.9668108019202505 0.9381456751919459 1.0 13.287749522268134 -6.757150032449427 24.99617382343975 0.9677669165686087 1.0106187828241329 0.49841910785800214 0.020496010255125683 86.51565421735786 504170.025149903 0.006553119459563263 0.006335992504572172 1.7492422866504447e-07 6.757150032449427 0.042851866255524174 ENLPENVTASES(ph)DAEVER ddPTM_A459_Selumetinib_30min_R2 2 ENLPENVTASESDAEVER 18 0 Q9NX02;A0A0G2JMG8;A0A0G2JLX3;J3KN39;A0A0G2JNC8;A0A0G2JP37;A0A0G2JPQ2;A0A0G2JPB6;A0A0G2JLQ8;Q9NX02-5;Q9NX02-2;Q9NX02-4;Q9NX02-3;K7EMK2 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 1 ENLPENVTASES(1)DAEVER;ENLPENVTASES(1)DAEVER 320.13 5.256399999999996e-127 31971000.0 82766.0 88370.0 102184.0 123366.0 122291.0 89717.0 98047.0 89265.0 81775.0 106780.0 True False 78166.19705854921 95147.69484566443 95609.5926895269 106563.33798177962 106927.71128458869 102074.70238016179 102606.37977644474 89524.74637138366 98132.28498440616 103696.98395224167 0.753794315701112 0.9175550842393384 0.9220093877904927 1.0276416335392944 1.031155460932547 0.9843555568325204 0.9894827782426225 0.8633302817429567 0.9463369255715444 1.0 16.66201440812101 -4.532834630459393 1.4877547088403515 0.9724302220323251 0.5433952671866684 0.6589194795531337 0.0471929279872634 1.4610502002290542 1.8901677754955684 0.014765716319386895 1.1047642513879878 2.932009475778549e-05 4.532834630459393 -0.4290349548456567 ENLQPQSSGVQGQVPIS(ph)PEPLQRPEMLK ddPTM_A459_Selumetinib_30min_R2 1 ENLQPQSSGVQGQVPISPEPLQRPEMLK 28 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 ENLQPQS(0.008)S(0.006)GVQGQVPIS(0.987)PEPLQRPEMLK 70.027 0.0002812 4817900.0 16974.0 15697.0 20939.0 20224.0 22887.0 20985.0 23965.0 27028.0 24425.0 18169.0 True False 16030.653032305698 16900.909426189854 19591.807536659442 17469.456311654056 20011.730447623984 23875.49326713663 25079.41998574662 27106.64700527373 29310.682491520907 17644.41376126872 0.9085398500172678 0.9578617717120796 1.1103688567803511 0.9900842582824309 1.1341680555888893 1.3531474374935462 1.421380178739545 1.5362735975266901 1.6611876647248454 1.0 14.106923876668471 -6.706113969624793 1.7213392870948803 1.452006644727488 0.9912069419663035 0.5639271843729861 0.16676054156567577 0.2410632491850785 1.4766162089066455 0.06654914176252393 0.06331967658738881 1.9673699353763706e-07 6.706113969624793 -0.4607997027611844 ENLS(ph)PGFSHLLSK ddPTM_A459_Selumetinib_30min_R1 1 ENLSPGFSHLLSK 13 0 H0YG46;J3KNE4;A0A0A0MTP3;Q99550-2;Q99550;F5H1U6 H0YG46 MPHOSPH9 M-phase phosphoprotein 9 1 ENLS(0.989)PGFS(0.011)HLLSK 94.845 0.012226 0.0 4572.2 5080.4 5260.8 5852.1 5272.2 4726.1 4700.1 4736.3 2641.6 3890.8 True False 4678.723364047509 4485.584406186118 4546.412255505901 4830.140592522253 4795.3304408825115 4678.559724955466 4345.567672927781 4610.677938329382 4482.6022651695375 4390.222079601389 1.0657145081080532 1.0217215268056297 1.0355768280220334 1.100204159366992 1.0922751409691567 1.0656772345740324 0.9898286679206756 1.0502151952067103 1.0210422579753724 1.0 12.100078205068716 -7.235221422768314 24.115345386750214 1.0194561290469344 1.063331182385831 0.44384022782163024 0.026296739532678474 543.731562331476 500125.74791397643 0.010974874004802113 0.00849833690325138 5.8180651113585975e-08 7.235221422768314 0.04387505333889652 ENLS(ph)PTTIETAMK ddPTM_A459_Selumetinib_30min_R2 2 ENLSPTTIETAMK 13 0 Q14765 Q14765 STAT4 Signal transducer and activator of transcription 4 1 ENLS(0.465)PT(0.465)T(0.068)IET(0.001)AMK;ENLS(0.608)PT(0.304)T(0.087)IET(0.001)AMK 138.39 0.00099051 5959800.0 26711.0 24195.0 36950.0 40281.0 44831.0 24534.2 28369.0 32248.0 27250.0 29487.0 True False 25226.509552605017 26050.6787008131 34572.67722811816 34794.658311399195 39198.92898577492 27913.563350706845 29688.214712107078 32341.83634105621 32700.76142861597 28635.63369357316 0.8809481858355637 0.9097294294087784 1.2073306146487508 1.215082532614193 1.3688863813959364 0.9747842024174107 1.0367577344296786 1.1294262486782283 1.1419604601226327 1.0 14.805523909551994 -5.247588554428912 21.40116181114693 1.140986467541632 0.8953383137319635 0.42973282014856284 0.10988308460898433 112.87567166184232 174398.9855257013 0.029639363387432713 0.07707655511426838 5.654724431789772e-06 5.247588554428912 -0.24564815380966842 ENLSPT(ph)TIETAMK ddPTM_A459_Selumetinib_30min_R1 2 ENLSPTTIETAMK 13 0 Q14765 Q14765 STAT4 Signal transducer and activator of transcription 4 1 ENLS(0.315)PT(0.557)T(0.126)IET(0.002)AMK;ENLS(0.17)PT(0.66)T(0.17)IET(0.001)AMK 106.3 0.016385 10842200.0 3083.1 3441.1 4085.8 4193.2 3655.2999999999997 3606.7000000000003 3742.2 3763.2 2139.49 2999.8 True False 3154.9302313317144 3038.2144122760114 3530.970801692902 3460.9363361125593 3324.678760395631 3570.4198726215855 3459.922841137497 3663.3877114036563 3630.5582678329692 3384.853550526433 0.9320728900785207 0.8975910971993131 1.0431679684173467 1.0224774231589113 0.9822223356985582 1.0548225556365036 1.0221780025311253 1.0822883934916192 1.0725894676501802 1.0 11.724877699998588 -5.264289646654232 24.995698031950475 1.0358295437818947 0.9148319872955397 0.718590771131109 0.030068147645765726 119.57216958761119 1048609.1994871567 0.008201050031792771 0.018347140578183974 5.44139625455457e-06 5.264289646654232 -0.12099755648635502 ENMT(ph)S(ph)QRGMLK ddPTM_A459_Selumetinib_30min_R1 1 ENMTSQRGMLK 11 1 E9PCW1;K7EJC8;G5E9T8;O95249-2;O95249 E9PCW1 GOSR1 Golgi SNAP receptor complex member 1 2 ENMT(1)S(1)QRGMLK 71.692 0.026853 0.0 475.01 692.28 718.44 488.96 671.84 562.96 802.34 569.82 334.63 553.59 True False 486.0768087914368 611.2275357677593 620.8797941084365 403.57231491595877 611.0721906229855 557.2971335267829 741.8188478323598 554.7065225637842 567.8426695917931 624.6486689232378 0.7781603211119147 0.9785141090933345 0.9939664086352765 0.6460788840095218 0.9782654170645153 0.8921769328148018 1.1875777292715577 0.8880296239484204 0.9090592805882926 1.0 9.286901169762068 -6.422129925130058 23.002133211543402 0.9767086677532952 0.8616861148252253 0.2024606696525303 0.12215097610437574 38.69728512781416 8822.730609008999 0.03829121421105837 0.04341812952793102 3.7832938537885324e-07 6.422129925130058 -0.11502255292806995 ENNVSQPASSSSSSSSSNNGSAS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 ENNVSQPASSSSSSSSSNNGSASPTK 26 0 A0A3B3IRW4;Q02446 A0A3B3IRW4 SP4 Transcription factor Sp4 1 ENNVSQPASSSSSSSSSNNGS(0.048)AS(0.827)PT(0.124)K 112.75 8.9248e-09 4560900.0 1195.9 1376.5 1179.0 1303.0 1377.4 1076.6 1212.6 1184.2 914.51 1282.4 True False 1223.7621431836785 1215.3387400825106 1018.8982757834282 1075.4555103392795 1252.8144131997221 1065.770381474589 1121.1326057301396 1152.7911691762886 1551.856676832296 1447.008531633808 0.84571867852219 0.839897425283512 0.7041411667649234 0.743226792951241 0.8657961482681636 0.7365335851000371 0.7747933624581164 0.7966719918884511 1.0724585535650606 1.0 10.498857712758054 -8.254606607936845 24.04358157851193 1.036229290326551 0.7861575164115898 0.7865140288622223 0.051647755363064624 123.17177789522307 433431.01039767265 0.03745490747562243 0.013406092397060492 5.5640803387291614e-09 8.254606607936845 -0.25007177391496127 ENNVSQPASSSSSSSSSNNGSAS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 ENNVSQPASSSSSSSSSNNGSASPTK 26 0 A0A3B3IRW4;Q02446 A0A3B3IRW4 SP4 Transcription factor Sp4 1 ENNVSQPASSSSSSSSSNNGS(0.011)AS(0.929)PT(0.06)K 178.35 5.4320000000000015e-22 0.0 16886.0 14380.0 15888.0 17510.0 19811.0 15233.0 16528.0 19401.0 12156.0 15709.0 True False 15947.543720013802 15482.899761012302 14865.783377546444 15125.107793565196 17322.165067412883 17331.207478593857 17296.584749610687 19457.453697991557 14587.539667018562 15255.440353116328 1.0453676426820477 1.0149100519310483 0.9744578349395017 0.9914566504450651 1.1354746022702893 1.136067335811352 1.1337978025706352 1.2754435957017036 0.9562188523806637 1.0 13.897036203916237 -6.261656649064475 24.997866140009748 1.1228157676181316 1.0048531698000684 0.24179066964684326 0.08332818394045734 23.742232311389383 2731660.1314800624 0.024241116549195123 0.02924797504216379 5.474486018386103e-07 6.261656649064475 -0.11796259781806318 ENPEDVLSPT(ph)SVATYLSSK ddPTM_A459_Selumetinib_30min_R2 1 ENPEDVLSPTSVATYLSSK 19 0 Q5JTU8;B1AMJ5;A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8 Q5JTU8 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 ENPEDVLS(0.147)PT(0.668)S(0.185)VATYLSSK 182.98 5.7096e-13 15054000.0 16176.0 20335.0 13712.0 19242.0 19558.0 16317.0 11670.0 16501.0 17684.0 20945.0 True False 15277.002677658604 21894.629112669325 12829.784848496785 16621.20640569856 17100.94918926158 18564.518639021608 12212.678123666305 16549.0151781124 21221.294132243835 20340.26342835453 0.7510720169121462 1.0764181688103407 0.6307580476372758 0.817157873310944 0.8407437420610141 0.9126980436813067 0.6004188769080399 0.8136086947154729 1.043314616204092 1.0 14.312050743323018 -8.256380511382014 22.81434101762191 1.0216573556807569 0.8068940150122024 0.31486254267958824 0.12761035948138552 137.9933082494971 622344.6483784518 0.09114552371390379 0.031871669957948504 5.541399850029726e-09 8.256380511382014 -0.21476334066855451 ENPPVEDS(ph)SDEDDKR ddPTM_A459_Selumetinib_30min_R2 2 ENPPVEDSSDEDDKR 15 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 ENPPVEDS(0.809)S(0.191)DEDDKR;ENPPVEDS(0.962)S(0.038)DEDDKR 139.02 0.00020292 52073000.0 77352.0 20791.3 46556.0 45859.0 30912.0 30346.0 106013.0 56227.0 48958.0 35126.0 True False 73053.0855045901 22385.92585543358 43560.63764634017 39612.92508881251 27028.55820321373 34525.88604643926 110942.81456077423 56390.61126111908 58750.96800081392 34111.82111169162 2.1415768236293777 0.6562512679148912 1.2769953707165174 1.1612667925030662 0.7923516635102738 1.0121384587879922 3.2523275200557746 1.6531105471173901 1.722305232794428 1.0 15.057984157035909 ENPPVEDSS(ph)DEDDKR ddPTM_A459_Selumetinib_30min_R1 1 ENPPVEDSSDEDDKR 15 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 ENPPVEDS(0.124)S(0.876)DEDDKR 71.402 0.025136 7675300.0 4410.2 11300.0 5347.4 6654.1 8792.1 5508.9 7730.9 6343.8 2192.7 4690.8 True False 4512.949079244631 9976.990746772526 4621.252451165653 5492.086347926788 7996.856107371334 5453.485467680995 7147.751988816703 6175.541816433494 3720.8517515283293 5292.909872261282 0.8526404545249835 1.8849727253167967 0.8731024262068764 1.037630808094681 1.510861945577556 1.0303378669380423 1.3504390139488582 1.166757410474312 0.7029879293861234 1.0 12.369845372613954 -8.139101605501272 5.7219359019278775 0.8567162780615549 1.230745428114098 0.18694152641514472 0.3023590510200246 0.34719272260814105 14.42224834641879 0.20024052306738538 0.0732888892949207 7.259361009590924e-09 8.139101605501272 0.374029150052543 ENPQEYPDFYDFSNAACRPS(ph)TPALSR ddPTM_A459_Selumetinib_30min_R2 1 ENPQEYPDFYDFSNAACRPSTPALSR 26 1 H0YJ41;Q9P203-5;Q9P203 H0YJ41 BTBD7 BTB/POZ domain-containing protein 7 1 ENPQEY(0.001)PDFY(0.044)DFS(0.142)NAACRPS(0.405)T(0.405)PALS(0.005)R 58.054 0.004456399999999999 4797600.0 10745.0 9244.4 8841.7 11822.0 11941.0 10438.0 12548.0 11171.0 5130.6 8490.3 True False 10147.83591564303 9953.415754568989 8272.834648115087 10211.823205912498 10440.864826105562 11875.739753270062 13131.506863390292 11203.5057605414 6156.863360941541 8245.162978551369 1.230762319925173 1.2071824147638317 1.0033561094711776 1.2385229051841813 1.2663018127435446 1.440328078918892 1.592631570479572 1.3587973687949826 0.7467242766404685 1.0 13.009332295732225 -8.25643060962418 24.982276349715146 0.8733621234223258 1.2920656951020684 0.5322617143567534 0.15706563768772286 329.6782818589058 1644359.5093430877 0.12874940696246873 0.045272845093472694 5.540760656137929e-09 8.25643060962418 0.4187035716797426 ENPVLDVVS(ph)NPEQTAGEER ddPTM_A459_Selumetinib_30min_R1 1 ENPVLDVVSNPEQTAGEER 19 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 ENPVLDVVS(0.998)NPEQT(0.002)AGEER 198.88 2.4171999999999995e-15 3636300.0 843.9 1049.0 575.04 681.32 955.33 723.41 956.03 819.16 536.56 930.77 True False 863.561228056448 926.1825923331309 496.9527264686195 562.3402519603666 868.9205701772104 716.133152203727 883.915887395831 797.4332157933194 910.5031312081182 1050.2433959675604 0.8222486629024435 0.8818742359049677 0.4731786254278615 0.5354380271463625 0.8273516153621682 0.6818735113720693 0.8416295601473442 0.759284199124781 0.8669448764962684 1.0 10.036507998708554 -8.363645411062565 0.677139292657888 0.9977207921670139 0.6953892792845341 0.3526926016379145 0.12384832178423873 0.873924990052085 0.9277931127232915 0.13127976836241156 0.055128610102238663 4.328671103238469e-09 8.363645411062565 -0.30233151288247984 ENPVLDVVS(ph)NPEQTAGEER ddPTM_A459_Selumetinib_30min_R2 2 ENPVLDVVSNPEQTAGEER 19 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 ENPVLDVVS(0.991)NPEQT(0.009)AGEER;ENPVLDVVS(0.999)NPEQT(0.001)AGEER 135.98 0.00018185 5689600.0 24054.0 20253.5 27256.0 27562.0 28104.0 23789.8 22047.7 20799.6 23926.0 24149.0 True False 22717.1749757913 21806.87832473315 25502.378634089 23808.008052898 24573.324267052234 27066.62900769725 23072.96173668875 20860.12339244086 28711.868548295988 23451.75562336278 0.9686769443034923 0.9298612297924939 1.0874400639192818 1.0151908639701293 1.0478245066894754 1.1541408431159548 0.9838479518225632 0.8894909075233531 1.2242950595857758 1.0 14.517408308017677 -5.253433070564031 24.67328504675978 1.046328059543519 0.9492690783620843 0.17315138494155935 0.08795401615172306 891.6613536646315 2747836.3981954013 0.021971093264958767 0.05583403859647455 5.579135759800389e-06 5.253433070564031 -0.09705898118143463 ENPYYDSR ddPTM_A459_Selumetinib_30min_R1 2 ENPYYDSR 8 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 ; 177.3 0.0029742 44000000.0 7687.4 8728.6 9845.2 10178.5 8851.7 8649.5 8499.9 8407.2 4587.4 7259.5 False True 7866.50146292349 7706.651454183947 8508.275915812561 8401.016049108484 8051.065297894561 8562.493883117644 7858.745699691252 8184.2137455656975 7784.48274956039 8191.327538518117 0.9603451242711031 0.940830581849514 1.038693163690996 1.025598843362611 0.9828767388480072 1.0453121112364498 0.9593982981069963 0.99913154578193 0.9503322523675658 1.0 12.999881567789771 -5.239070535402713 24.976266990412828 1.0005838017110498 0.9505878431420741 0.3086527647145533 0.029675851048365138 954.7186094726904 1066001.4796602277 0.007535613694208564 0.01991166273751764 5.7667279618498615e-06 5.239070535402713 -0.04999595856897565 ENPYYDSR ddPTM_A459_Selumetinib_30min_R2 1 ENPYYDSR 8 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 167.23 0.0032923 24355000.0 67203.0 68162.0 65051.0 77956.0 86772.0 62845.0 64464.0 63244.0 46614.0 69498.0 False True 63468.12629492407 73389.80622462572 60865.6894821736 67338.25831839927 75870.92560847773 71501.32829989045 67461.70373299262 63428.0295693922 55938.10250398181 67491.41216251059 0.9403881806784696 1.087394734724361 0.9018286554090302 0.9977307654529061 1.1241567360568832 1.0594137240412824 0.9995598191152612 0.9397940795291957 0.8288180779102695 1.0 16.042416319953304 -7.796766775675024 3.423843855767474 0.9069402903920887 1.0204357753406001 0.25798888786036955 0.07270813808569446 0.300447546639434 7.209840592954103 0.04350069220622627 0.020045715889146335 1.5967363945859196e-08 7.796766775675024 0.11349548494851147 ENQEPLRS(ph)PEVGDEEALRPLTK ddPTM_A459_Selumetinib_30min_R1 1 ENQEPLRSPEVGDEEALRPLTK 22 2 P48681 P48681 NES Nestin 1 ENQEPLRS(0.999)PEVGDEEALRPLT(0.001)K 46.786 0.030124 13851000.0 3161.9 3244.4 2969.7 2972.0 3224.1 3061.9 4031.6 3258.0 1733.5 3141.7 True False 3235.5661180136062 2864.54413971936 2566.4310513944415 2452.995991349453 2932.4807242610887 3031.1000659827646 3727.4931661402175 3171.5872565245313 2941.6228901693626 3544.9677977494807 0.9127208772016778 0.8080592837931879 0.7239645598540381 0.6919656626801336 0.8272235155768611 0.8550430466271246 1.0514885829164973 0.8946730795518115 0.829802429245436 1.0 11.791556806841085 -6.879434924023564 2.989283140967913 0.936464360285904 0.7824147158865065 0.44160218264809703 0.07897547448841806 0.2564151322076269 4.599536088641297 0.03158924781215955 0.027491577057524388 1.3199730855809904e-07 6.879434924023564 -0.1540496443993975 ENQEPLRS(ph)PEVGDEEALRPLTK ddPTM_A459_Selumetinib_30min_R2 2 ENQEPLRSPEVGDEEALRPLTK 22 2 P48681 P48681 NES Nestin 1 ENQEPLRS(0.999)PEVGDEEALRPLT(0.001)K;ENQEPLRS(1)PEVGDEEALRPLTK 54.875 0.01041 49256000.0 91231.0 73979.0 87124.0 90934.0 98520.0 68544.0 80095.0 84441.0 75205.0 75745.0 True False 86160.74624662906 79652.95142002303 81518.53669343881 78548.63233010043 86143.03682002518 77985.31381951938 83819.57620523166 84686.70933004 90248.10140326843 73558.0450408552 1.1713300183382271 1.0828584606317724 1.1082205440365123 1.0678455672180165 1.1710892638892196 1.0601874176537074 1.1395024998105516 1.15129091974921 1.2268964102178537 1.0 16.166595517165774 -7.48210768238291 24.609550818313043 1.1425356144593877 1.1089290614034617 0.004789289349590442 0.06325452582403959 1278.5856524287253 771761.0396523366 0.024894936123318747 0.01678123318916971 3.2952799628915196e-08 7.48210768238291 -0.03360655305592597 ENQPENSQT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 ENQPENSQTPTK 12 0 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 ENQPENSQT(1)PTK;ENQPENS(0.011)QT(0.989)PTK 255.39 8.3943e-19 14399100.0 5427.1 7031.700000000001 5131.6 5304.6 5013.0 5140.0 4706.5 4079.2000000000003 2985.8 4463.5 True False 5553.54087070168 6208.425295051356 4434.756905861105 4378.251189674403 4559.575035117033 5088.296266746596 4351.48491577511 3971.0063648909972 5066.684525796186 5036.433703171787 1.1026732799449412 1.2327026743430547 0.8805351499153529 0.8693157594662902 0.9053181881944671 1.0102974776660214 0.8640012302821899 0.788455998614691 1.0060063974644098 1.0 12.298186808083159 -5.26656133053811 24.99512994246333 0.9074706819040436 1.167687984376602 0.6457766566648124 0.07452394830651249 218.02993988598513 1063990.9640809847 0.01907986133809763 0.04174705125609785 5.413008006447265e-06 5.26656133053811 0.26021730247255836 ENQPENSQT(ph)PTK ddPTM_A459_Selumetinib_30min_R2 3 ENQPENSQTPTK 12 0 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 ENQPENS(0.002)QT(0.765)PT(0.233)K;ENQPENS(0.005)QT(0.995)PT(0.001)K;ENQPENS(0.001)QT(0.998)PT(0.001)K 115.09 0.012491 18353800.0 49210.0 41761.0 51112.0 58321.0 52627.0 48920.0 49658.0 49144.0 40464.0 54061.0 True False 46475.10520323812 44963.934417220735 47823.50956653791 50377.57919066343 46015.52576865065 55658.28594845479 51967.195395460294 49287.00090377285 48557.93065862446 52500.11846265332 0.8852381016301673 0.8564539611316582 0.9109219363106356 0.9595707717593097 0.8764842273905425 1.0601554354215044 0.9898491073392124 0.9387978988815775 0.9249108779281481 1.0 15.68003305766706 -5.7623311115699085 1.0745081017792089 0.9718465383391772 0.8649790978866119 0.41178085634824957 0.046012428877414815 0.6174821194939908 1.3665504699891742 0.018004390444378085 0.0515614725779662 1.7284980281076718e-06 5.7623311115699085 -0.10686744045256535 ENQPENSQT(ph)PTKK ddPTM_A459_Selumetinib_30min_R1 3 ENQPENSQTPTKK 13 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 ENQPENS(0.004)QT(0.812)PT(0.184)KK;ENQPENS(0.025)QT(0.774)PT(0.201)KK;ENQPENSQT(0.998)PT(0.001)KK 274.02 1.6500999999999995e-36 252618000.0 18475.8 20113.0 22080.0 22359.1 19630.5 18587.600000000002 18232.6 17051.5 11552.6 15253.5 True False 18906.25019235137 17758.16060971997 19081.65727675836 18454.50291728855 17854.924741046278 18400.625620190476 16857.300302849522 16599.238828922047 19603.91843147999 17211.435306672098 1.0984702818493162 1.0317652359205587 1.1086615925262933 1.0722233554882301 1.0373873197039372 1.0690930356666641 0.979424435120452 0.9644308294548375 1.1390054392430848 1.0 14.07107979206264 -6.702400673423805 1.6364424698997067 1.0210157016882366 1.0754188339379 0.1729621818531457 0.04969899083819262 0.6481323172354035 3.594838280382673 0.0206808934650585 0.019716916923566807 1.9842634216524136e-07 6.702400673423805 0.05440313224966342 ENQPENSQT(ph)PTKK ddPTM_A459_Selumetinib_30min_R2 6 ENQPENSQTPTKK 13 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 ENQPENS(0.025)QT(0.636)PT(0.339)KK;ENQPENS(0.001)QT(0.967)PT(0.032)KK;ENQPENS(0.007)QT(0.963)PT(0.03)KK;ENQPENS(0.016)QT(0.968)PT(0.016)KK;ENQPENS(0.001)QT(0.878)PT(0.12)KK;ENQPENS(0.004)QT(0.861)PT(0.134)KK 208.38 0.001251 551934000.0 281302.0 255576.0 274663.0 302251.0 294633.0 248578.0 295178.0 290586.0 209054.0 322402.0 True False 265668.3609811274 275177.85739363526 256991.48161046376 261083.8923879421 257618.56848756032 282817.36313358566 308904.3618841107 291431.5571508978 250870.6414568032 313093.41655900446 0.8485274583570189 0.8789001711307981 0.8208140702378265 0.8338849639744474 0.8228169449197296 0.9033002553737406 0.9866204319434986 0.9308134305531642 0.8012645050603452 1.0 18.25623364756516 -6.889665217031633 5.137473735928459 0.9265598696554682 0.8419269212937489 0.3970336787560328 0.05203811025576787 0.23273879847875603 9.589264198950618 0.018730632089490416 0.016494020790651737 1.289243002682641e-07 6.889665217031633 -0.0846329483617193 ENQPENSQTPT(ph)KK ddPTM_A459_Selumetinib_30min_R1 1 ENQPENSQTPTKK 13 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 ENQPENSQT(0.459)PT(0.541)KK 125.39 0.0026628 110920000.0 8331.2 7929.8 9580.5 9131.2 7707.6 7210.5 7095.3 7366.9 5401.3 6979.1 True False 8525.300750306766 7001.3753295359975 8279.520721919542 7536.607333852667 7010.448940887307 7137.968916610181 6560.0958085412 7171.50588093633 9165.611604656353 7874.9354671908195 1.082586744466104 0.889070819526799 1.0513763263730016 0.9570373452902919 0.8902230335848205 0.9064161790720638 0.833034865602695 0.9106748761072172 1.1638967256103685 1.0 12.94305238574356 -8.247182188361103 24.85743553728694 1.0819483694186145 0.9362806337971653 0.3303517377844253 0.08066703961736403 723.2985022478533 1261078.5261219367 0.05511530552526192 0.02062403253184478 5.660017990933072e-09 8.247182188361103 -0.1456677356214492 ENQSEGKGS(ph)DSDSEGDNPEK ddPTM_A459_Selumetinib_30min_R1 1 ENQSEGKGSDSDSEGDNPEK 20 1 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 ENQS(0.003)EGKGS(0.691)DS(0.227)DS(0.079)EGDNPEK 133.17 7.467e-05 12408000.0 1993.8 1742.5 2467.2 2233.7 1923.5 1974.6 1623.4 1675.8 1109.4 1455.8 True False 2040.2516607405435 1538.4872899337265 2132.1677913595195 1843.6262267420177 1749.5197646215074 1954.7373167933529 1500.945630993161 1631.3523402344404 1882.5707726298772 1642.666110692839 1.242036739821711 0.9365794301830623 1.2979921954195668 1.1223377743906935 1.0650489184826488 1.189978477104449 0.9137253281253221 0.9931125562372338 1.1460459069407913 1.0 10.68182355168185 -7.248170423481833 24.853705271262598 1.0126469878639446 1.1356308594487365 0.2592398613470618 0.1065548617998531 1056.469715561 1978845.9892840437 0.03954280215373941 0.03042650743728311 5.6471532880435825e-08 7.248170423481833 0.12298387158479196 ENQSEGKGSDS(ph)DSEGDNPEK ddPTM_A459_Selumetinib_30min_R2 2 ENQSEGKGSDSDSEGDNPEK 20 1 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 ENQSEGKGS(0.007)DS(0.883)DS(0.111)EGDNPEK;ENQS(0.01)EGKGS(0.004)DS(0.926)DS(0.06)EGDNPEK 97.488 0.00051352 16853000.0 32754.0 36297.0 33840.0 30331.0 28169.0 22270.2 23986.4 20415.8 12776.3 31489.0 True False 30933.6638046507 39080.86318674988 31662.771242206167 26199.86547610658 24630.15838594485 25337.717901252632 25101.815128149923 20475.206597982375 15331.916999648669 30579.83075175247 1.011570798274544 1.2779947509850174 1.0354135540920755 0.8567694729508964 0.805438021743575 0.8285761326458806 0.820861806984049 0.6695657266451346 0.5013735073981738 1.0 14.900292801477628 -5.788027265247764 1.900672975327291 0.7580388404621733 1.1527559346789678 0.5629444628884549 0.13453702450603366 0.23748973216799155 1.7515676078803364 0.0420907450140159 0.08264224723325246 1.6291937477444834e-06 5.788027265247764 0.39471709421679446 ENQSEGKGSDS(ph)DSEGDNPEKK ddPTM_A459_Selumetinib_30min_R1 1 ENQSEGKGSDSDSEGDNPEKK 21 2 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 ENQSEGKGS(0.009)DS(0.731)DS(0.26)EGDNPEKK 106.11 0.00099745 0.0 644.87 512.4 771.64 681.11 556.86 544.95 422.44 425.99 349.12 514.16 True False 659.8942163014117 452.40796979170284 666.8555263151181 562.1669245181788 506.49211132161804 539.4682977750115 390.575010691605 414.6913613894673 592.431141284066 580.1574443425127 1.1374398841839632 0.7798020592572293 1.1494388856301925 0.9689902801390019 0.8730252731577393 0.9298653374798734 0.6732224407363077 0.7147910716881921 1.0211558035861508 1.0 9.180300664752762 -6.387291322696058 2.0559029715082806 0.8376191725028352 1.005011729948742 0.17972663873277728 0.14138514318110035 0.51948519479355 4.328324366480712 0.0493406362742659 0.058516241620564596 4.0992903227181933e-07 6.387291322696058 0.16739255744590675 ENQSEGKGSDS(ph)DSEGDNPEKK ddPTM_A459_Selumetinib_30min_R2 1 ENQSEGKGSDSDSEGDNPEKK 21 2 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 ENQS(0.032)EGKGS(0.125)DS(0.718)DS(0.125)EGDNPEKK 46.514 0.034499 5889800.0 32486.0 35802.0 33321.0 26064.0 20581.0 16498.0 21043.0 17160.0 13149.0 31706.0 True False 30680.55817176169 38547.898278425746 31177.163137161715 22514.038237092147 17995.430783525553 18770.449746067203 22021.54119591346 17209.93275900908 15779.167413756733 30790.565397918774 0.996427242412232 1.251938630559584 1.0125557206971287 0.7311992471113875 0.5844462597865098 0.6096169233493827 0.7152041838569799 0.5589352626883672 0.5124676084974813 1.0 14.910200738951806 -5.743669062470059 2.904462542464565 0.6421650131212356 1.1271426433938734 0.651862352793995 0.14004506077776266 0.13599887170806646 2.344714201356439 0.038138312977756605 0.06821548865305344 1.8043921853004108e-06 5.743669062470059 0.48497763027263774 ENQSEGKGSDSDS(ph)EGDNPEK ddPTM_A459_Selumetinib_30min_R1 1 ENQSEGKGSDSDSEGDNPEK 20 1 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 ENQS(0.002)EGKGS(0.068)DS(0.362)DS(0.567)EGDNPEK 74.744 0.0034939 15186000.0 2109.4 1986.6 3076.4 2810.3 2319.3 2341.9 1827.4 2319.3 1337.5 1506.0 True False 2158.5449158221 1754.0079484547152 2658.6417774555894 2319.5338608645256 2109.519724505672 2318.3426122750698 1689.5577467518199 2257.784629851855 2269.639812865026 1699.3097696822479 1.2702480467853274 1.0321884683701286 1.5645421599339866 1.3649858914765451 1.2413979853126653 1.3642848723859065 0.994261185862392 1.3286480606028856 1.335624530240548 1.0 10.730733152162797 ENS(ph)FGSPLEFR ddPTM_A459_Selumetinib_30min_R1 1 ENSFGSPLEFR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ENS(0.915)FGS(0.085)PLEFR 123.68 0.0037932 3718600.0 819.62 1258.1 890.33 859.35 1044.3 735.18 836.02 1068.2 428.93 804.73 True False 838.7155512971041 1110.8010671251784 769.4280762326212 709.2806544973602 949.8432493861394 727.7847566900319 772.9583383164364 1039.8678659973925 727.8628821922961 908.0249342339944 0.9236701765295031 1.22331559987639 0.847364480009249 0.7811246451020709 1.046054148488139 0.8015030526711117 0.8512523270833973 1.1451974794884021 0.801589091610483 1.0 9.826588104033016 -5.282264950053338 24.996933373941566 0.9088352597951515 1.0734929357517236 0.19842664703551927 0.13203304178783262 1081.775952831811 1298454.3226608962 0.03334811156176337 0.06952448320634466 5.2207758792789384e-06 5.282264950053338 0.1646576759565721 ENS(ph)FGSPLEFR ddPTM_A459_Selumetinib_30min_R2 2 ENSFGSPLEFR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ENS(0.753)FGS(0.247)PLEFR;ENS(0.94)FGS(0.06)PLEFR 110.55 0.0087584 4321500.0 19039.8 17777.1 17754.5 17875.9 16065.8 17483.7 19109.0 19863.4 17837.3 17107.3 True False 17981.644138358326 19140.546407614165 16612.194799637993 15441.1715823525 14047.470573925691 19891.920973773493 19997.606363765164 19921.199205437108 21405.258415803728 16613.367798896616 1.0823599619309328 1.1521171769209488 0.9999293942520974 0.9294425892008501 0.8455522530993782 1.1973442841068398 1.2037057510454512 1.1991066138173492 1.2884358352209218 1.0 14.020056940162458 -6.803242948661021 24.99939100108974 1.19178712600303 1.0060940096848112 0.42018290118613777 0.1025554362999125 145.96066528344318 87286.45800329835 0.037940496424293556 0.03346067238806688 1.5731026090015315e-07 6.803242948661021 -0.18569311631821872 ENS(ph)PAAFPDR ddPTM_A459_Selumetinib_30min_R2 1 ENSPAAFPDR 10 0 K7EJD2;A0A0A0MR03;Q9Y5B0;A0A0J9YWJ4;A0A0J9YWB6;Q9Y5B0-4 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 ENS(1)PAAFPDR 86.46700000000001 0.035018 20502000.0 124510.0 104080.0 136880.0 115040.0 104740.0 86027.0 119980.0 123910.0 103370.0 111850.0 True False 117590.23265302135 112062.60133005297 128073.28982367585 99371.35354493087 91581.62481251954 97876.43837464685 125559.30773585968 124270.55758559519 124046.88839912042 108620.59987879971 1.0825776398236622 1.0316882935197733 1.1790884046541974 0.9148481379757682 0.8431331157690855 0.9010854155092005 1.1559437885259372 1.1440790947965478 1.1420199164572242 1.0 16.72893821040298 -10.255466920613005 9.606338061241262 0.9999936392162159 1.039801696204956 0.012062605032271412 0.11386037530186327 0.0 0.0 0.12282677707649389 0.02978986914944579 5.553069121830709e-11 10.255466920613005 0.03980805698874024 ENS(ph)PNSFPR ddPTM_A459_Selumetinib_30min_R1 1 ENSPNSFPR 9 0 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 ENS(0.998)PNS(0.002)FPR 97.163 0.020837 12725000.0 3766.0 5247.5 3082.0 3610.9 3616.5 3551.5 4081.6 4226.0 2252.0 4037.8 True False 3853.74047263963 4633.120260503432 2663.481328214188 2980.3240999878008 3289.388213544935 3515.7751345039956 3773.721625884986 4113.912752017394 3821.479520427693 4556.090961502642 0.8458436201564838 1.0169068834778894 0.5845979263187815 0.6541406054379699 0.7219759748738781 0.7716648250026289 0.8282805716065811 0.9029478969534416 0.8387627799176627 1.0 12.1535808351319 -8.212351903205256 0.8637904772755337 0.9822866969024873 0.76340164028819 0.27421622342944707 0.11234103742479999 0.8252383681446271 1.288663209775257 0.11572388310176984 0.04338852161963254 6.132648831780881e-09 8.212351903205256 -0.21888505661429725 ENS(ph)PNSFPR ddPTM_A459_Selumetinib_30min_R2 3 ENSPNSFPR 9 0 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 ENS(1)PNSFPR;ENS(1)PNSFPR;ENS(0.997)PNS(0.003)FPR 110.93 0.010566 40886700.0 189815.0 145643.0 152996.0 163552.0 166383.0 148204.0 157532.0 183045.0 134147.0 164203.0 True False 179265.84218964924 156813.34978394382 143152.40392944994 141275.93545706288 145480.4800571074 168617.75573803755 164857.55014373612 183577.63064526892 160980.1483803504 159462.03273937007 1.124191377157766 0.9833898834103328 0.8977209274851204 0.8859534337428701 0.9123204913290264 1.0574163193669548 1.033835749561682 1.1512309701038 1.0095202325901715 1.0 17.282853439499164 -6.7771161631510966 24.49285120139419 1.0588173316220313 0.9543218174590494 0.26437375204481006 0.07375543188085967 244.7165384603243 382333.4858808306 0.027282563459261607 0.02414732994399167 1.6706436982183648e-07 6.7771161631510966 -0.10449551416298186 ENS(ph)PSSQSAGLSSINK ddPTM_A459_Selumetinib_30min_R1 1 ENSPSSQSAGLSSINK 16 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2 H3BSS6 ZNF106 Zinc finger protein 106 1 ENS(0.718)PS(0.281)S(0.001)QSAGLSSINK 205.98 5.5111e-29 0.0 1618.0 1561.7 1073.9 1028.5 1125.7 1154.4 1315.6 1406.2 768.52 1113.1 True False 1655.6962519200526 1378.8554379853674 928.070278510453 848.8917823361082 1023.8806337584773 1142.787784111337 1216.363232804363 1368.903008018661 1304.1223095200223 1255.9772275121584 1.3182534011382183 1.0978347439599732 0.7389228547947291 0.6758815078340189 0.8152063678627213 0.9098793824271582 0.9684596234389832 1.089910691080113 1.0383327666722348 1.0 10.294594591206025 -7.53346356841534 3.8500128775482283 1.0475220116821282 0.9099783423922528 0.07826460190239348 0.1730329563540868 0.5855770961636969 19.45153226615838 0.09454539377472254 0.05482014848964857 2.927766462097579e-08 7.53346356841534 -0.13754366928987538 ENS(ph)PSSQSAGLSSINK ddPTM_A459_Selumetinib_30min_R2 2 ENSPSSQSAGLSSINK 16 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2 H3BSS6 ZNF106 Zinc finger protein 106 1 ENS(0.906)PS(0.083)S(0.011)QSAGLSSINK;ENS(0.989)PS(0.01)S(0.001)QSAGLSSINK 227.09 4.4107e-15 10091800.0 79348.0 65997.0 69090.0 81920.0 85707.0 71806.0 87222.0 88041.0 82372.0 67213.0 True False 74938.15581521118 71058.75768619808 64644.82461950423 70762.35468011761 74939.72042969835 81696.62471003152 91277.99582711422 88297.18473402777 98848.70166597988 65272.386049653505 1.1480835978357649 1.0886496110643604 0.990385498859014 1.0841085941961401 1.1481075683780089 1.2516261416869898 1.398416717257401 1.3527494562073925 1.5144030676430988 1.0 15.994185157921164 -6.779401041463535 2.090733873204739 1.3452176487404939 1.0744301474444709 0.4089168472681576 0.12849111499847693 0.27072705628329663 2.434446331997635 0.04886726242173054 0.04441289268437817 1.6618773107406253e-07 6.779401041463535 -0.270787501296023 ENS(ph)SPCQGNGEQAGR ddPTM_A459_Selumetinib_30min_R2 2 ENSSPCQGNGEQAGR 15 0 Q5T5X7 Q5T5X7 BEND3 BEN domain-containing protein 3 1 ENS(0.701)S(0.299)PCQGNGEQAGR;ENS(0.991)S(0.009)PCQGNGEQAGR 260.25 2.2183e-36 11866300.0 34128.6 25443.9 30067.4 32052.3 34781.6 28501.9 29207.3 38153.8 27740.5 24136.0 True False 32231.869039610494 27395.365314966675 28132.89621890987 27686.72144669847 30412.02445655079 32427.778010512353 30565.497323167012 38264.82124129841 33289.37513433106 23439.130967140853 1.3751307198545935 1.1687875865949142 1.2002533821902004 1.181217916547857 1.297489420541452 1.3834889209831465 1.3040371405414544 1.632518769358027 1.420247840288925 1.0 14.516631460715836 -6.589596647892841 2.9960890856254756 1.3858497530179634 1.2248557837758594 0.08409493301682613 0.156907728946458 0.45069378074922223 8.215054392696779 0.053373596492764366 0.054557809732372994 2.5727841533354374e-07 6.589596647892841 -0.16099396924210407 ENSFGS(ph)PLEFR ddPTM_A459_Selumetinib_30min_R1 2 ENSFGSPLEFR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ENS(0.047)FGS(0.953)PLEFR;ENS(0.029)FGS(0.971)PLEFR 109.99 0.0090784 41413000.0 5748.7 8546.0 4230.5 5225.5 6270.4 5766.5 7564.3 6640.7 4029.9 6906.4 True False 5882.633524977016 7545.43034707239 3656.0213364731067 4312.964519783503 5703.243427129035 5708.49424556308 6993.718760947134 6464.567063966373 6838.445967749363 7792.903714032856 0.7548705515742516 0.9682437540560349 0.46914750529890764 0.5534476849774304 0.7318508782367061 0.7325246730924785 0.8974470900177283 0.8295453532071084 0.8775221943824637 1.0 12.927945275757033 -7.1618171401937785 2.324902209411912 0.8919048512155463 0.6900992008503285 0.36364393833622466 0.12930251933334094 0.4034141821660902 4.26589418510244 0.06353215570559938 0.04492742350846439 6.889423146272491e-08 7.1618171401937785 -0.2018056503652178 ENSFGS(ph)PLEFR ddPTM_A459_Selumetinib_30min_R2 4 ENSFGSPLEFR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ENS(0.026)FGS(0.974)PLEFR;ENS(0.001)FGS(0.999)PLEFR;ENS(0.003)FGS(0.997)PLEFR;ENS(0.005)FGS(0.995)PLEFR 165.78 0.0006326000000000001 309541000.0 158188.0 124983.0 176685.0 189116.0 205525.0 167571.0 181785.0 211478.0 184962.0 167452.0 True False 149396.54423673716 134568.7942163144 165317.27946008238 163358.0745567038 179705.1120831876 190652.38419191568 190238.3627001441 212093.36596793216 221959.56827007935 162617.22566745433 0.9187006088902726 0.8275186940619818 1.0166037378976662 1.0045557835967789 1.105080420266653 1.1723996852694567 1.1698536973516807 1.3042490738444557 1.3649203973260355 1.0 17.311120561300804 -6.173298694305368 0.8382284634641142 1.2387488835451919 0.8673854264476185 0.6321116807133984 0.09664327550295242 0.3968293203048239 0.5884180559535065 0.048415789281461674 0.09080003052104006 6.709672237036852e-07 6.173298694305368 -0.37136345709757335 ENSGPVENGVS(ph)DQEGEEQAR ddPTM_A459_Selumetinib_30min_R2 2 ENSGPVENGVSDQEGEEQAR 20 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 1 ENSGPVENGVS(1)DQEGEEQAR;ENS(0.002)GPVENGVS(0.998)DQEGEEQAR 216.31 2.5851e-19 16862700.0 31176.0 17601.0 24902.0 31274.0 28975.0 35751.0 51094.0 47181.0 42865.0 21824.0 True False 29443.362727416195 18950.94010386491 23299.832431247578 27014.427249340843 25334.90146021344 40675.37573473441 53469.97224084032 47318.28889876495 51439.19774816962 21193.884414438267 1.3892386195782966 0.8941702112404953 1.0993658347676294 1.2746331310053456 1.1953873563146413 1.9192034333746029 2.5228962843835303 2.232638810964238 2.427077393756419 1.0 14.371360408593306 -6.820357131656316 3.644281252569729 2.1570286084430266 1.1485995347969136 0.5093613499066711 0.4120525612186362 0.1617765658633299 4.344617090376728 0.14153110165178703 0.12737645377349116 1.5123171192365634e-07 6.820357131656316 -1.008429073646113 ENSLCGSAPNS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 ENSLCGSAPNSR 12 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 ENSLCGS(0.043)APNS(0.957)R 172.09 0.00023898 11936000.0 2171.0 2334.1 1864.8 1975.4 2044.7 1697.5 1945.0 1857.7 936.04 1806.2 True False 2221.5800759693666 2060.8224869063483 1611.5704026131777 1630.4334728505096 1859.757246021104 1680.4246912066824 1798.2870840715166 1808.4277613399709 1588.3915143433119 2038.043363877873 1.0900553517871525 1.0111769569932667 0.7907439219285174 0.7999994022444221 0.9125209399286106 0.8245284280945161 0.8823595787725724 0.8873352713648828 0.7793708134457997 1.0 10.992969033018609 -5.089592103536327 4.332533627516143 0.8554252549406689 1.0753310064505452 0.5997503937225435 0.06365822878806418 0.12778778115120126 4.130118776250437 0.015550442037993769 0.04827392305445356 8.1359429846988e-06 5.089592103536327 0.21990575150987635 ENSLCGSAPNS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 ENSLCGSAPNSR 12 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 ENSLCGS(0.345)APNS(0.655)R 113.11 0.0060962 14578000.0 15883.0 16526.0 17292.0 18116.0 22545.0 22440.0 18176.0 19142.0 18490.0 19714.0 True False 15000.286444686675 17793.491060534714 16179.451546106073 15648.569548156893 19712.69554514278 25530.906309961683 19021.22001506072 19197.700050871306 22188.51665376546 19144.805596876635 0.7835173028413455 0.9294161265047068 0.8451092106542809 0.8173793914475614 1.0296628735869113 1.3335683238343723 0.9935446938235781 1.0027628619014706 1.1589836491933554 1.0 14.22466539017649 -6.376720605887463 4.710752773198018 1.0995361076328027 0.8509796823384751 0.5851181168992232 0.10092996209516021 0.16920797413630953 5.849568143365243 0.03230569648825295 0.0367617605183722 4.200291138821406e-07 6.376720605887463 -0.24855642529432764 ENSPAVS(ph)PT(ph)TNSTAPFGLKPR ddPTM_A459_Selumetinib_30min_R2 3 ENSPAVSPTTNSTAPFGLKPR 21 1 Q9Y2L9-2;Q9Y2L9;Q9Y2L9-3 Q9Y2L9-2 LRCH1 Leucine-rich repeat and calponin homology domain-containing protein 1 2 ENS(0.047)PAVS(0.97)PT(0.887)T(0.086)NS(0.007)T(0.005)APFGLKPR;ENS(0.268)PAVS(0.825)PT(0.852)T(0.041)NS(0.008)T(0.006)APFGLKPR;ENS(0.053)PAVS(0.953)PT(0.81)T(0.092)NS(0.039)T(0.052)APFGLKPR 66.20100000000001 0.031947 12532200.0 91324.0 98732.0 97549.0 92503.0 94221.0 96639.0 92729.0 108307.0 80924.0 90965.0 True False 86248.5776789376 106304.42692658308 91272.80354332052 79903.9318234243 82384.11563357271 109950.14504850208 97041.08223902766 108622.15543881089 97111.06120547936 88338.6040945461 0.9763407353214274 1.2033745384159422 1.0332153703225153 0.9045188413652718 0.9325947186736109 1.2446443565128764 1.0985127423472478 1.2296114088757384 1.0993049097939602 1.0 16.4307564149863 -6.757548158201073 24.99994057965755 1.146521522329106 1.0161800838161716 0.27633442106100903 0.0994528855602625 136.66186924131017 878010.9205665732 0.03446072202278098 0.033238245609829735 1.7476394588068506e-07 6.757548158201073 -0.13034143851293445 ENSQLDTS(ph)PPCLGGNKK ddPTM_A459_Selumetinib_30min_R1 1 ENSQLDTSPPCLGGNKK 17 1 Q9Y3E2 Q9Y3E2 BOLA1 BolA-like protein 1 1 ENS(0.043)QLDT(0.435)S(0.522)PPCLGGNKK 59.728 0.032129000000000005 13862000.0 2807.9 3198.9 3340.6 3532.5 2942.1 2772.8 3052.0 2939.2 1684.8 2772.0 True False 2873.318606777698 2824.371300871737 2886.9648686023083 2915.615188237533 2675.9875744699425 2744.908149500964 2821.7851828207035 2861.2428681328724 2858.982547076634 3127.8132015665287 0.918634976455317 0.9029859262238498 0.9229978526711268 0.9321577090272786 0.8555458405027849 0.8775805882928714 0.9021591127652525 0.914774215640452 0.914051563451662 1.0 11.610938639628083 -9.10385679990199 1.215225691562078 1.0000530601560937 0.9018861275175029 0.6500192533879757 0.021193064693233843 1.9158339597576888 3.3871275272503603 0.022395263860715647 0.00671283780650688 7.873053454161602e-10 9.10385679990199 -0.09816693263859089 ENSQLDTS(ph)PPCLGGNKK ddPTM_A459_Selumetinib_30min_R2 2 ENSQLDTSPPCLGGNKK 17 1 Q9Y3E2 Q9Y3E2 BOLA1 BolA-like protein 1 1 ENS(0.004)QLDT(0.094)S(0.903)PPCLGGNKK;ENS(0.001)QLDT(0.285)S(0.715)PPCLGGNKK 95.414 0.0032878 34465000.0 67135.0 67713.0 66260.0 68097.0 66763.0 49788.0 59896.0 60835.0 46389.0 66222.0 True False 63403.90546269843 72906.36936838856 61996.903738433226 58822.071126122784 58375.63507120717 56645.845069535324 62681.282681672434 61012.01977822363 55668.09621695654 64309.998794580766 0.9859105372591191 1.1336708246763674 0.9640321085444887 0.9146644725342393 0.9077225340599188 0.8808248504322584 0.9746739831529031 0.9487174766261223 0.8656211671651833 1.0 15.97275544198442 -5.459579336302171 5.958549213263252 0.925435122622953 1.0591616865115179 0.5164825730352965 0.05047798210539964 0.15470255073174086 10.875631458434093 0.01264224053779522 0.02639273201678765 3.470728673152927e-06 5.459579336302171 0.13372656388856485 ENSS(ph)SQDPQTEGTR ddPTM_A459_Selumetinib_30min_R2 2 ENSSSQDPQTEGTR 14 0 A0A0C4DG49;P15151-3;P15151-2;P15151 A0A0C4DG49 PVR Poliovirus receptor 1 ENS(0.031)S(0.937)S(0.031)QDPQT(0.001)EGTR;ENS(0.014)S(0.493)S(0.493)QDPQTEGTR 229.02 3.1474000000000003e-13 11078600.0 42055.0 9327.4 24942.7 34283.0 16713.0 11101.4 53898.0 25560.0 18246.6 14964.1 True False 39717.75145950374 10042.78158768192 23337.91383755839 29613.596258526304 14613.363523884287 12630.517081524455 56404.3637968609 25634.375368314217 21896.429852601254 14532.047551598951 2.7331146088311296 0.691078222254848 1.6059618408687726 2.0378130578899696 1.005595630759988 0.8691491709394199 3.881377596418253 1.7639892298242366 1.5067683872388653 1.0 13.826950371193337 ENSSALS(ph)PNHR ddPTM_A459_Selumetinib_30min_R2 4 ENSSALSPNHR 11 0 A0AVK6 A0AVK6 E2F8 Transcription factor E2F8 1 ENSSALS(1)PNHR;ENSSALS(1)PNHR;ENSSALS(1)PNHR;ENSSALS(1)PNHR 91.657 0.017271 6751600.0 74041.0 70582.0 83592.0 109233.0 100103.0 83210.0 68010.0 72224.0 78288.0 89143.0 True False 69926.09762960678 75995.41244309935 78213.78172808791 94355.27696256475 87527.1662078256 94671.42219482684 71172.59975925836 72434.15988267322 93947.78754948555 86569.20996867093 0.8077479008404117 0.8778572944191336 0.90348267884613 1.089940372526347 1.0110657846999107 1.0935923087329558 0.8221468092987733 0.8367196594365003 1.0852332784772427 1.0 16.4015663730453 -5.3853185906395575 2.8715748506405743 0.9826709968846074 0.8374394221987542 0.28966899119607414 0.0928718807220671 0.38654864448187004 6.038845592188547 0.02720117609414643 0.06883779850853956 4.117953226079295e-06 5.3853185906395575 -0.14523157468585313 ENVATTDTLESTTVGT(ph)SV ddPTM_A459_Selumetinib_30min_R1 2 ENVATTDTLESTTVGTSV 18 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 ENVATTDTLESTTVGT(0.872)S(0.128)V;ENVATTDTLESTTVGT(0.573)S(0.427)V 156.08 5.7142e-05 5397700.0 1596.02 1523.6399999999999 1849.87 1507.81 1600.48 1443.73 1435.1599999999999 1218.01 782.1600000000001 863.98 True False 1633.2041606856876 1345.2515204789815 1598.6678146085587 1244.4992885991314 1455.7168665876948 1429.2073870019576 1326.9047257460556 1185.7044181459319 1327.268393293838 974.8802488778678 1.6752869519775184 1.3799146326201892 1.6398607074547866 1.276566316767221 1.4932263406334185 1.4660337909677024 1.3610950958062638 1.2162564781784557 1.3614681339801327 1.0 9.929081203549268 -12.060262185983845 0.08379455309802518 6.110773761562073e-12 1.9191492037019624 0.6653422081447427 0.10931424623613896 75.21999320076714 0.7611542562166291 17.883112741437277 3.7935521983790546 8.70437943097358e-13 12.060262185983845 1.9191492036958517 ENVELS(ph)PTTGHCNSGR ddPTM_A459_Selumetinib_30min_R2 1 ENVELSPTTGHCNSGR 16 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 ENVELS(0.994)PT(0.005)TGHCNSGR 106.0 0.0023617 4944600.0 25994.0 18416.0 25054.0 37298.0 38767.0 30205.0 33477.0 35626.0 35662.0 28111.0 True False 24549.35754222662 19828.447983226873 23442.052916732657 32217.94805736122 33896.742878622754 34365.46457630982 35033.746833417026 35729.66576179823 42795.39647953403 27299.36238885051 0.8992648689938987 0.7263337399896609 0.858703312657103 1.1801721812564947 1.2416679333311724 1.2588376272973034 1.2833174025971157 1.3088095338223278 1.5676335538522448 1.0 14.736579635120007 -5.821739755719328 2.5304057632019292 1.2902219183898873 0.801475468639427 0.691545265408648 0.13435478198121284 0.14671523562575173 1.912293912921883 0.039065719562269154 0.06778230445142788 1.5075101478230907e-06 5.821739755719328 -0.48874644975046033 ENVEYIEREES(ph)DGEYDEFGR ddPTM_A459_Selumetinib_30min_R1 3 ENVEYIEREESDGEYDEFGR 20 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 ENVEY(0.001)IEREES(0.998)DGEY(0.001)DEFGR;ENVEYIEREES(0.993)DGEY(0.007)DEFGR;ENVEYIEREES(0.995)DGEY(0.004)DEFGR 97.059 0.00052748 60094000.0 5875.4 6883.9 7586.6 7521.700000000001 7288.599999999999 6193.5 6849.9 5989.599999999999 3383.0400000000004 5312.5 True False 6012.285388461731 6077.929787761715 6556.381390210824 6208.176294795825 6629.347416906844 6131.1990132480605 6333.206528113869 5830.736351037239 5740.771792534504 5994.411123132103 1.0029818217273507 1.0139327555141018 1.0937490364833518 1.0356607458635618 1.1059213792201468 1.0228192373372758 1.0565185466966678 0.9726954376780644 0.9576873648824622 1.0 12.549402318290658 -7.764510875177024 24.991958100974205 0.9738935262181198 1.048724377603096 0.4993273390700598 0.03232593924394047 64.32142394945068 523347.22519178037 0.016893295437543074 0.008663679443669142 1.7198442740432995e-08 7.764510875177024 0.07483085138497614 ENVEYIEREES(ph)DGEYDEFGR ddPTM_A459_Selumetinib_30min_R2 6 ENVEYIEREESDGEYDEFGR 20 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 ENVEY(0.001)IEREES(0.999)DGEYDEFGR;ENVEY(0.001)IEREES(0.995)DGEY(0.004)DEFGR;ENVEYIEREES(0.969)DGEY(0.03)DEFGR;ENVEYIEREES(0.993)DGEY(0.007)DEFGR;ENVEYIEREES(0.955)DGEY(0.045)DEFGR;ENVEY(0.005)IEREES(0.989)DGEY(0.007)DEFGR 94.72 0.00060356 614375500.0 188737.0 218958.3 227208.0 239935.9 239369.0 166994.0 149461.0 156055.9 128959.7 223209.0 True False 178247.7531140735 235751.69754809892 212589.68464536616 207256.2165074856 209297.32623398874 189995.90767940017 156411.2326513529 156509.99683255484 154755.24343507862 216764.3762033697 0.8223111022026993 1.0875942886801437 0.9807408780394486 0.956135967254308 0.9655522272609254 0.876508912613689 0.7215725913588629 0.7220282205675539 0.7139330094068883 1.0 17.72576815318736 -6.991997412851794 3.127574641461856 0.7670057916297438 0.9699588858288825 0.39521865348514074 0.09883464571774571 0.2170809784987815 4.381567577367289 0.03713397460322328 0.030294200341955232 1.0185974559523777e-07 6.991997412851794 0.20295309419913865 ENVEYIEREES(ph)DGEYDEFGRK ddPTM_A459_Selumetinib_30min_R2 1 ENVEYIEREESDGEYDEFGRK 21 2 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 ENVEY(0.066)IEREES(0.923)DGEY(0.011)DEFGRK 47.082 0.032935 35964000.0 51737.0 54657.0 52060.0 51206.0 50750.0 35735.0 31421.0 31941.0 25068.0 51494.0 True False 48861.66465962062 58849.01615004516 48710.51627864224 44231.654464723026 44374.33128924355 40657.17187996793 32882.138759530324 32033.9430218828 30082.300458442 50007.234422520305 0.9770919192767079 1.1768100521780311 0.9740693889823648 0.8845051116204838 0.8873582352968508 0.8130258021559045 0.6575476356421373 0.6405861750166413 0.6015589705335657 1.0 15.609849200646915 -6.253237491120491 0.9334737729567437 0.7011120944773259 1.0770956296003924 0.5359862525685845 0.11918837521590642 0.40245475074482345 0.7456117485150212 0.05624632028458608 0.09098867447039184 5.581648824198481e-07 6.253237491120491 0.3759835351230665 ENVEYIEREESDGEY(ph)DEFGRK ddPTM_A459_Selumetinib_30min_R2 1 ENVEYIEREESDGEYDEFGRK 21 2 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 ENVEY(0.001)IEREES(0.004)DGEY(0.994)DEFGRK 78.794 0.006563600000000001 6713200.0 17614.0 20765.0 18498.0 16755.0 13516.0 12655.0 13690.0 10420.0 10792.0 15097.0 True False 16635.08439442869 22357.60873000143 17307.858819099576 14472.940096012855 11817.999245426912 14398.11137934782 14326.612126220369 10450.320474876142 12950.70155367426 14661.110383283276 1.13464014385951 1.5249601254959357 1.180528511594466 0.9871653454376161 0.8060780484199817 0.9820614539376683 0.9771846573473517 0.7127918828570916 0.8833370198508812 1.0 13.83970675203835 -5.7143401342485545 2.7140613911170264 0.8893071911831603 1.3340907770665713 0.6744948141994727 0.12202563367553432 0.1404006284145293 2.0994157591194154 0.0342744032493367 0.06378439050143869 1.9304558148815157e-06 5.7143401342485545 0.44478358588341105 ENVPNSDSQPPPSCLTTAVPS(ph)PSKPR ddPTM_A459_Selumetinib_30min_R2 1 ENVPNSDSQPPPSCLTTAVPSPSKPR 26 1 Q8IY92 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 ENVPNSDSQPPPS(0.001)CLT(0.002)T(0.002)AVPS(0.717)PS(0.279)KPR 74.873 0.00011041 8560700.0 22540.0 16819.0 19286.0 19105.0 20709.0 14950.0 15132.0 18682.0 12916.0 16405.0 True False 21287.31703476909 18108.963218391218 18045.159757009107 16502.866042036738 18107.350279191018 17009.226797412088 15835.667983489157 18736.361527028417 15499.56090319279 15931.34502469115 1.3361908239245965 1.1366876550802893 1.1326827539697286 1.0358739966060504 1.1365864119524993 1.0676579266251773 0.9939944153457407 1.1760690323378171 0.9728971960101824 1.0 13.959580452974915 -1.5228789178084854 0.7985095919070395 1.0600387142417849 68.18208223769602 0.6482893407538861 0.06159263064547371 298.0148041825412 1.0431604805935033 0.020603140534443686 36179.520229786525 0.02999998808218013 1.5228789178084854 67.12204352345424 ENVSDLTLGPGNS(ph)PITR ddPTM_A459_Selumetinib_30min_R1 2 ENVSDLTLGPGNSPITR 17 0 Q6DCA0 Q6DCA0 AMMECR1L AMMECR1-like protein 1 ENVSDLT(0.008)LGPGNS(0.99)PIT(0.002)R;ENVSDLTLGPGNS(0.999)PIT(0.001)R 251.41 1.2552999999999999e-30 33346000.0 5538.799999999999 6379.1 6722.700000000001 6699.1 6427.200000000001 4824.5 6024.5 5798.8 3197.0 4170.4 True False 5667.843263371316 5632.2320064368705 5809.794265147795 5529.227942681401 5845.86089481432 4775.969910295515 5570.067114647224 5644.996986842989 5425.075500358498 4705.711463136022 1.2044604323432322 1.1968927654317736 1.2346261156598795 1.175003606999007 1.2422905527910268 1.0149304622074449 1.1836822461985739 1.199605422275721 1.1528704092585973 1.0 12.20019714719952 -6.6916982225003885 24.999999713569583 1.127270871515974 1.2092413755149234 0.36699546352962986 0.06400987350875507 64.22904229223955 23022.92841967013 0.020794945327018973 0.020794939100610366 2.0337697223111306e-07 6.6916982225003885 0.08197050399894934 ENVSDLTLGPGNS(ph)PITR ddPTM_A459_Selumetinib_30min_R2 3 ENVSDLTLGPGNSPITR 17 0 Q6DCA0 Q6DCA0 AMMECR1L AMMECR1-like protein 1 ENVSDLTLGPGNS(0.999)PIT(0.001)R;ENVSDLTLGPGNS(0.996)PIT(0.004)R;ENVSDLTLGPGNS(0.986)PIT(0.014)R 231.4 1.726e-16 21141100.0 87537.0 84609.0 112704.0 118409.0 129775.0 96036.0 89307.0 94109.0 77808.0 110475.0 True False 82672.04397837551 91098.23823918542 105452.7473428369 102281.48993308163 113471.50429678 109264.08727199117 93459.95245846325 94382.84160941633 93371.77413716509 107285.29970147833 0.7705812838143783 0.8491213474042254 0.9829188867091716 0.9533597819801984 1.0576612510056345 1.0184441631427494 0.8711347474305972 0.8797369431975943 0.8703128424581218 1.0 16.71109288510086 -5.034501972885041 3.211379540145623 0.9526657964202098 0.7759120804419327 0.4887091188094713 0.0613679633101793 0.2391224107940029 4.7833393157918165 0.018022898418236462 0.07719862257980994 9.236299926031733e-06 5.034501972885041 -0.17675371597827705 ENYSHHTQDDR ddPTM_A459_Selumetinib_30min_R1 3 ENYSHHTQDDR 11 0 Q92804-2;Q92804;A0A075B7D9;A0A075B7E4;A0A075B7F2 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 ;; 123.62 0.0021489 2266960.0 1345.1100000000001 1980.31 1435.53 1331.8500000000001 1117.52 1756.1799999999998 1323.3 1247.4299999999998 927.1000000000001 1416.71 False True 1376.448445871559 1748.4543845788578 1240.5929108018531 1099.267399420852 1016.4405133141804 1738.5144236838596 1223.4824156050586 1214.3441041763028 1573.220987295078 1598.5585284239958 0.861056021032015 1.0937693887896884 0.7760697458008887 0.687661652591857 0.6358481689852669 1.0875513112415378 0.7653660431259146 0.7596494482898375 0.984149756997701 1.0 10.6425558515026 -8.32387626248731 8.649801940549775 0.9937133457557713 0.8349618058832777 0.16296143247174588 0.14384436564574213 0.8851100807908434 114.03053013616605 0.1440128392191442 0.03735255793091242 4.74377123712529e-09 8.32387626248731 -0.15875153987249357 ENYSHHTQDDR ddPTM_A459_Selumetinib_30min_R2 4 ENYSHHTQDDR 11 0 Q92804-2;Q92804;A0A075B7D9;A0A075B7E4;A0A075B7F2 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 ;;; 144.7 0.00041487 10873500.0 14555.02 10372.83 19448.899999999998 30347.3 33449.8 26667.899999999998 26765.5 43396.4 44942.1 47555.2 False True 13746.110256761523 11168.392707094663 18197.57894836122 26213.94538798752 29247.53707899385 30341.161157906743 28010.148784832087 43522.67633933924 53931.77578719267 46182.15781275177 0.2976498047686711 0.24183349665854845 0.39403916599445954 0.5676206273053216 0.6333081532824794 0.6569888154842555 0.6065145093133338 0.9424132262464748 1.1678054543458574 1.0 15.495047962644753 -6.792881614029739 0.43803912567618797 1.1029115947461645 0.19085957278694243 0.8679880870289057 0.10539157878211608 0.4617864166652656 0.1862978121087406 0.11284310230897061 0.16849825916678163 1.6110847469915046e-07 6.792881614029739 -0.9120520219592221 down ENYSHHTQDDRR ddPTM_A459_Selumetinib_30min_R1 4 ENYSHHTQDDRR 12 1 Q92804-2;Q92804;A0A075B7D9;A0A075B7E4;A0A075B7F2 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 ;;; 132.17 0.0012966 7550000.0 3424.53 3596.21 3884.68 3786.95 3534.39 3768.34 3215.61 4070.08 2412.1400000000003 3136.42 False True 3504.3148860245856 3175.16406136733 3357.161793019821 3125.6302723555914 3214.705048547234 3730.433920978965 2973.0539487975366 3962.1282569169302 4093.2254042648538 3539.010058317926 0.9901963623381644 0.8971898946442863 0.9486160642943929 0.8831933848306688 0.9083627894731579 1.0540896633540573 0.8400806722235241 1.1195583486982543 1.1566018001684752 1.0 11.789130146754355 -7.778303385755757 24.999948558828837 1.103560154448218 0.9329476254929221 0.5437734388947819 0.06706354361358773 171.67118031288967 254489.31147732132 0.03459718970041293 0.01668887518433674 1.6660829278492675e-08 7.778303385755757 -0.170612528955296 ENYSHHTQDDRR ddPTM_A459_Selumetinib_30min_R2 9 ENYSHHTQDDRR 12 1 Q92804-2;Q92804;A0A075B7D9;A0A075B7E4;A0A075B7F2 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 ;;;;;;;; 116.84 0.0033158000000000003 26952000.0 30317.74 24512.829999999998 35917.99 48312.549999999996 58380.24 43737.65 39963.409999999996 65866.34999999999 58813.74 84741.56 False True 28632.80138232922 26392.88523982858 33607.06562795063 41732.29734620267 51045.99232523246 49762.114276644206 41821.78775099459 66058.01017373882 70578.13139319805 82294.85097778532 0.3479294395959033 0.3207112586782991 0.4083738560632733 0.5071070285730014 0.620281727455972 0.6046807751079954 0.5081944648309038 0.8026991894252354 0.8576251193680383 1.0 16.328514546512245 -7.039317121149893 0.252181976106689 1.0774635094818301 0.14732857118260018 0.9013307945590345 0.0676015348337244 0.9070020979801241 0.15126942538316335 0.14936172798628675 0.29282123280744643 9.134460010528772e-08 7.039317121149893 -0.9301349382992299 down EPAESAAVAHERPPGGT(ph)GSADPERPPGATCPESPGPGPPHPLGVVESGK ddPTM_A459_Selumetinib_30min_R2 1 EPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGK 49 2 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 EPAES(0.003)AAVAHERPPGGT(0.421)GS(0.175)ADPERPPGAT(0.183)CPES(0.217)PGPGPPHPLGVVES(0.001)GK 44.549 0.00037468 5092900.0 11178.0 10610.0 9621.8 11342.0 8016.7 5448.7 9552.8 8092.3 6074.3 10714.0 True False 10556.771509079372 11423.752883472913 9002.743863423739 9797.200033958688 7009.570475792684 6199.208966626033 9997.02412851409 8115.8472532476135 7289.329730122642 10404.658981684914 1.014619655258497 1.0979459205325122 0.8652608297178279 0.9416166403151203 0.6736953597548437 0.5958108744878963 0.9608218920112255 0.7800204953890133 0.7005832428486013 1.0 13.344942060288773 -5.610840556991746 1.6054896323636698 0.7802623856654077 1.0571064489400392 0.3738617224085834 0.12591269857606777 0.40537698265579214 2.0523567860991823 0.03928483163719023 0.1051674984798339 2.4499625341809598e-06 5.610840556991746 0.2768440632746315 EPAESAAVAHERPPGGTGSADPERPPGAT(ph)CPESPGPGPPHPLGVVESGK ddPTM_A459_Selumetinib_30min_R2 1 EPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGK 49 2 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 EPAES(0.07)AAVAHERPPGGT(0.08)GS(0.08)ADPERPPGAT(0.704)CPES(0.065)PGPGPPHPLGVVESGK 45.79600000000001 0.00065303 8436100.0 13913.0 11320.0 13694.0 13426.0 13622.0 11419.0 11366.0 15214.0 14275.0 15570.0 True False 13139.77115815184 12188.207600463084 12812.942948899863 11597.35563885816 11910.682577774889 12991.863598638707 11894.541521301728 15258.270221186707 17130.39887682542 15120.453644281693 0.8690064112673687 0.8060742016872267 0.8473914374748609 0.7669978634036612 0.7877199228264764 0.8592244587550464 0.7866524246645237 1.0091145795058294 1.132928897494015 1.0 13.884213803535532 -7.858084018538782 4.429821613523103 1.0673016567136706 0.8168158746759068 0.8531983214406236 0.04397008831195188 0.06973122065816588 2.391985759970708 0.024294328335757568 0.011184478210470009 1.3864875732673198e-08 7.858084018538782 -0.25048578203776384 EPAFEDITLES(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 EPAFEDITLESER 13 0 O75400-3;O75400;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 EPAFEDIT(0.006)LES(0.994)ER 87.863 0.024565 1035200.0 948.72 503.63 851.69 791.48 2057.8 941.11 1221.9 756.54 502.37 1151.4 True False 895.9939404270691 542.256801574313 796.8931926499583 683.6790586208448 1799.2807670345883 1070.7393599540126 1278.720771148917 758.7414061480608 602.8580373905983 1118.1560903035281 0.801313831044687 0.4849562652984479 0.712685106811553 0.6114343646201107 1.6091499054896405 0.9575938182864576 1.1435977340174421 0.6785648378860033 0.5391537394631102 1.0 10.126905881598306 EPAITSQNS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 6 EPAITSQNSPEAR 13 0 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193;E5RIS7 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 EPAITSQNS(1)PEAR;EPAITSQNS(1)PEAR;EPAITSQNS(1)PEAR;EPAITSQNS(1)PEAR;EPAIT(0.001)S(0.004)QNS(0.995)PEAR;EPAIT(0.016)S(0.041)QNS(0.943)PEAR 187.08 0.00013811 620581200.0 8496.43 10243.0 8842.5 10270.900000000001 9153.18 8546.19 9213.24 7712.99 4974.349999999999 7352.989999999999 True False 8694.38028782515 9043.74479815849 7641.737068375717 8477.280123671306 8325.276485125187 8460.223087919663 8518.277889177916 7508.416449877573 8441.10863785057 8296.817890687827 1.0479174549056378 1.0900257083271645 0.9210443291701799 1.021750776666561 1.0034300613575358 1.0196949239316484 1.0266921609474702 0.9049754434534305 1.0173910948828575 1.0 13.01834240502797 -5.236919520440917 24.97984017777249 0.990052841989057 1.0689715944921607 0.3715884610468225 0.04139809618985052 810.2444043438479 825441.4089185607 0.010346940057458282 0.027345410870794718 5.795360809066429e-06 5.236919520440917 0.07891875250310376 EPAITSQNS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 5 EPAITSQNSPEAR 13 0 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193;E5RIS7 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 EPAIT(0.001)SQNS(0.999)PEAR;EPAITSQNS(1)PEAR;EPAITSQNS(1)PEAR;EPAITSQNS(1)PEAR;EPAITSQNS(1)PEAR 177.39 0.00010385 919074700.0 146534.3 127268.7 148039.0 178300.0 162550.0 123810.0 129295.8 131780.9 106837.9 144971.0 True False 138390.51022927984 137029.80005663034 138514.33191267628 154015.2324153441 142129.01578456248 140863.70366472186 135308.3108947671 132164.36060149758 128208.46530034229 140785.31055010637 0.9829897003354323 0.973324557236819 0.9838692074581046 1.093972317236386 1.0095443567884015 1.0005568273728926 0.9610967960084873 0.9387652737709412 0.9106664949587343 1.0 17.103137286380225 -7.313430053654453 2.6775368972870277 0.9441197490829573 1.0097881154785968 0.3384748845825394 0.03755335925954691 0.32561821568092736 4.602255071176887 0.01877512230396369 0.01211839290101934 4.85925786585384e-08 7.313430053654453 0.06566836639563955 EPALPLEPDSGGNT(ph)SPGVTANGEAR ddPTM_A459_Selumetinib_30min_R2 1 EPALPLEPDSGGNTSPGVTANGEAR 25 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;Q5VY93 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 EPALPLEPDS(0.034)GGNT(0.538)S(0.4)PGVT(0.027)ANGEAR 58.249 0.012956 3957200.0 24393.0 25825.0 31754.0 28836.0 33492.0 23919.0 27050.0 28133.0 22905.0 30296.0 True False 23037.334712915806 27805.69445953702 29710.98221114109 24908.48705512543 29284.43553772107 27213.625134936443 28307.878598558127 28214.862372331125 27486.64001917241 29421.275761538745 0.7830161716859195 0.9450879929512196 1.0098468350574066 0.8466147850626959 0.9953489364320306 0.9249641434825788 0.962156734058551 0.9589952047292009 0.9342436487782965 1.0 14.844572185453552 -4.762702472696427 6.478126037464694 0.9512430741652195 0.7783345358169199 0.5670845579047926 0.04456981663888248 0.08303901891884201 16.331490567329126 0.010324320736604685 0.06357383525285992 1.727020637443473e-05 4.762702472696427 -0.17290853834829956 EPALPLEPDSGGNTS(ph)PGVTANGEAR ddPTM_A459_Selumetinib_30min_R1 2 EPALPLEPDSGGNTSPGVTANGEAR 25 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;Q5VY93 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 EPALPLEPDSGGNT(0.112)S(0.883)PGVT(0.005)ANGEAR;EPALPLEPDSGGNT(0.233)S(0.754)PGVT(0.012)ANGEAR 173.55 7.3838e-17 27544000.0 7186.0 7510.599999999999 9310.0 9422.1 9288.2 7259.299999999999 8512.5 7811.8 4695.3 6563.1 True False 7353.419818478062 6631.255460416791 8045.753136169397 7776.707109721972 8448.083949964903 7186.278032917039 7870.3952715469295 7604.605687697464 7967.581168856193 7405.537815007677 0.9929622941869265 0.8954454930981831 1.08645088812649 1.0501205049499718 1.1407792601969375 0.9703924566226241 1.0627715998691138 1.0268809474291478 1.0758950082881904 1.0 12.854388797336165 -5.266428726435183 24.99843073919687 1.0532434569216849 0.9442038918483763 0.4293623395763534 0.04952553452994972 327.4924628863383 1640863.9557581714 0.012312475066759778 0.026965409717431506 5.4146610246035305e-06 5.266428726435183 -0.10903956507330859 EPALPLEPDSGGNTS(ph)PGVTANGEAR ddPTM_A459_Selumetinib_30min_R2 1 EPALPLEPDSGGNTSPGVTANGEAR 25 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;Q5VY93 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 EPALPLEPDSGGNT(0.282)S(0.699)PGVT(0.018)ANGEAR 82.211 0.00010259 4255500.0 36725.0 28845.0 40315.0 42917.0 42001.0 30443.0 27618.0 36564.0 31351.0 36789.0 True False 34683.97152182319 31057.31874870651 37721.176791653124 37071.630564045576 36724.458886295935 34636.24691596095 28902.291724028782 36670.395186503934 37622.07602012987 35726.80598069874 0.9708108679113678 0.8693001766092693 1.0558228130449678 1.0376418923111508 1.027924491938523 0.9694750472424836 0.8089805660109423 1.0264112388416409 1.0530489638635776 1.0 15.124719320570856 -1.522888728752688 0.004642477154315116 1.9048253104947312 0.00011165869546593798 0.01873147622267457 0.07731566721901034 405975.43493456865 145.8885122248491 27932.18983880899 32054.180927715854 0.029999310374088206 1.522888728752688 -1.9047136517992653 EPAPAEALPQQYPEPAPAALCGPPPRAPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 EPAPAEALPQQYPEPAPAALCGPPPRAPSR 30 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 EPAPAEALPQQYPEPAPAALCGPPPRAPS(1)R 64.221 0.00031701 13181000.0 372.26 385.75 605.57 498.16 296.18 619.77 390.25 381.39 196.84 407.03 True False 380.9329337081326 340.5862106696901 523.3369201579055 411.16570762134717 269.3905712948262 613.5356765061357 360.8131283079224 371.2742982706847 334.0231033752163 459.27626530794527 0.829420029908832 0.7415715472283912 1.139481744842633 0.8952470194506135 0.5865545242452264 1.3358749903933296 0.7856123983807367 0.8083899088966525 0.7272814395301995 1.0 8.843218418995907 -10.776011118043483 5.234768132285521 1.0000150600949265 0.8776774394725594 0.03320408095672822 0.20501146647341822 3.532491817662908e-05 5.039809903581493e-06 0.19459865299072632 0.04719129699165268 1.674899997633687e-11 10.776011118043483 -0.12233762062236708 EPAPAEALPQQYPEPAPAALCGPPPRAPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 EPAPAEALPQQYPEPAPAALCGPPPRAPSR 30 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 EPAPAEALPQQY(0.002)PEPAPAALCGPPPRAPS(0.998)R 49.81399999999999 0.011872 3488600.0 3784.6 5664.9 5693.2 6146.4 3752.1 3662.8 2896.0 3576.6 2838.3 6389.0 True False 3574.2670829541776 6099.3796144755615 5326.9057102874785 5309.2497168685995 3280.727653800408 4167.317452412108 3030.669738315135 3587.007313861996 3406.0393087281 6204.532969384443 0.576073509576142 0.9830521724313902 0.8585506333147852 0.8557049729716134 0.528763030189183 0.6716569116443184 0.4884605744331809 0.578126884257312 0.5489598210751414 1.0 12.599106903863646 -6.252163861009834 24.767682961477483 0.6093073015452225 0.8329819191769363 0.2154471050565685 0.16490200952791548 720.4330704373233 1923714.060160962 0.045942974251430804 0.05847592343355112 5.59546442596664e-07 6.252163861009834 0.2236746176317138 EPAPAS(ph)PAPAGVEIR ddPTM_A459_Selumetinib_30min_R1 2 EPAPASPAPAGVEIR 15 0 Q14195-2 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 EPAPAS(1)PAPAGVEIR;EPAPAS(1)PAPAGVEIR 167.92 6.959e-05 5754900.0 2295.66 2439.23 2397.69 2707.54 2825.27 2355.06 2411.77 2283.9300000000003 1499.3799999999999 1959.3000000000002 True False 2349.144411423231 2153.643817632738 2072.096867568421 2234.718965820424 2569.7248273419314 2331.370234623393 2229.848247172832 2223.352757149808 2544.338349617617 2210.7952401981606 1.0625789167216904 0.9741489299749442 0.9372631304302486 1.0108213212998047 1.1623531571886316 1.054539195775736 1.0086181689865426 1.00568009045945 1.1508701951925497 1.0 11.110349696234026 -6.013755941272311 24.836588369531615 1.0630997445042027 0.9870171845531345 0.2354111900024276 0.060187743505203214 849.0223054863553 1532927.7571542747 0.017735297509570574 0.023940220209651312 9.688221484060987e-07 6.013755941272311 -0.07608255995106827 EPDATPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 EPDATPPSPR 10 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 EPDATPPS(1)PR 120.03 0.0052145 13883000.0 2132.1 2215.0 1409.1 1628.0 1706.4 1438.8 1897.8 1813.6 629.13 1591.0 True False 2181.7737816555896 1955.6667702744378 1217.751959632255 1343.7003613448562 1552.0564212893885 1424.326978325876 1754.6474180724535 1765.4974365969572 1067.587660162822 1795.2203476523607 1.215323670160452 1.0893742224077927 0.6783300786584384 0.7484877068723265 0.8645492589915429 0.7933995290263348 0.9773994709713685 0.9834433076172111 0.5946833554771837 1.0 10.809945217821916 -5.079301651393674 5.095569467544374 0.8324873343932502 1.1892409261693615 0.5144341578605439 0.12770640842889364 0.1532183878865323 6.874129039786241 0.03263090175870589 0.09555444968015056 8.331023290612608e-06 5.079301651393674 0.3567535917761113 EPDEEKS(ph)DQQGEALDSSQK ddPTM_A459_Selumetinib_30min_R2 2 EPDEEKSDQQGEALDSSQK 19 1 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 EPDEEKS(0.999)DQQGEALDSSQK;EPDEEKS(0.998)DQQGEALDS(0.001)S(0.001)QK 74.812 0.005312600000000001 9905000.0 37017.0 20195.4 21480.9 31382.0 27814.0 27577.0 50127.0 46742.0 33983.0 23718.0 True False 34959.74333079182 21744.322241554077 20098.842280635552 27107.71746303044 24319.756659685107 31375.48143091862 52458.004824766125 46878.01148144531 40780.54956435434 23033.199713235284 1.5177979510464337 0.9440426216188889 0.8726031350775116 1.1768976000088196 1.055856631404561 1.3621850989678048 2.2774953318631987 2.035236617798628 1.7705116992894876 1.0 14.491427220109903 -7.043520553379688 5.702850964153334 1.8572860445103017 1.1028281661585662 0.43456115242121574 0.34788435595797285 0.1633668294801355 13.460941073857299 0.12806273244084698 0.10112034884498798 9.046476234569137e-08 7.043520553379688 -0.7544578783517355 EPDPDS(ph)DWEPEER ddPTM_A459_Selumetinib_30min_R1 1 EPDPDSDWEPEER 13 0 Q9NPE2-3;Q9NPE2 Q9NPE2-3 NGRN Neugrin 1 EPDPDS(1)DWEPEER 109.99 0.0057457 9094500.0 937.44 1411.8 1253.2 1039.6 1042.3 899.74 1269.9 1083.3 468.66 870.41 True False 959.280528059292 1246.5057996719859 1083.022323334854 858.0533757089141 948.0241490330116 890.6894324985567 1174.110420597645 1054.5673649456803 795.2817904279048 982.1356020113712 0.9767292073464469 1.2691789169633967 1.1027217841577794 0.8736607999462171 0.9652680822195011 0.9068904850556921 1.1954667137543102 1.0737492488674394 0.809747440983915 1.0 9.939778418839524 -5.568137144770334 11.503678033065585 0.9842377043844022 1.1386811791691902 0.22053882740780928 0.12047967261778804 0.9445619271440365 237.35042893167076 0.03301679023309331 0.057236049998432674 2.703104622654328e-06 5.568137144770334 0.15444347478478804 EPDPDS(ph)DWEPEER ddPTM_A459_Selumetinib_30min_R2 2 EPDPDSDWEPEER 13 0 Q9NPE2-3;Q9NPE2 Q9NPE2-3 NGRN Neugrin 1 EPDPDS(1)DWEPEER;EPDPDS(1)DWEPEER 83.869 0.030161 32256000.0 46317.0 42804.0 49774.0 49132.0 46031.0 41351.0 52141.0 50090.0 45631.0 44536.0 True False 43742.88656164155 46086.929163447196 46571.595029833625 42440.13684257257 40248.17425763881 47046.7249029958 54565.65981543141 50235.75360715412 54758.475036666954 43250.12996157544 1.0113931819512192 1.0655905358987832 1.0767966494253096 0.9812718916747188 0.9305908281292185 1.0877822782219002 1.261629961896276 1.1615168243837624 1.2660881039043312 1.0 15.400416847434967 -7.015864363973607 8.77049105537885 1.184383378775677 1.0168757469321077 0.4735974426369921 0.07865858897775431 0.1808100818311676 86.70231267250132 0.028320175363896014 0.02302953901607272 9.641300874431573e-08 7.015864363973607 -0.16750763184356932 EPEAASS(ph)RGSPVR ddPTM_A459_Selumetinib_30min_R2 1 EPEAASSRGSPVR 13 1 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EPEAAS(0.182)S(0.695)RGS(0.123)PVR 64.476 0.04334 32769000.0 54899.0 94906.0 95946.0 101270.0 101630.0 35418.0 14395.0 22498.0 17213.0 77338.0 True False 51847.93335810954 102184.98502911223 89772.9388181062 87476.85129950577 88862.33081627231 40296.50800740746 15064.396023151368 22563.4654552556 20656.080971404284 75105.05099174437 0.6903388343855691 1.3605607569635298 1.1952982873012648 1.164726608189392 1.1831738297606662 0.5365352592841844 0.20057766853533276 0.3004254062451246 0.27502918510334046 1.0 16.19662231519446 -6.832013878749031 4.390625642480649 0.3849704319801179 1.1406330350799774 0.6051031170989998 0.26328588024979516 0.1275158481186888 4.731564675845619 0.09004734742966676 0.08039166177181792 1.472265452492946e-07 6.832013878749031 0.7556626030998594 EPEAASSRGS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 4 EPEAASSRGSPVR 13 1 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EPEAAS(0.003)S(0.015)RGS(0.982)PVR;EPEAASS(0.001)RGS(0.998)PVR;EPEAAS(0.002)S(0.009)RGS(0.989)PVR;EPEAAS(0.006)S(0.035)RGS(0.959)PVR 101.72 0.0054354 273485000.0 13055.199999999999 10685.5 25248.199999999997 26743.300000000003 19811.100000000002 14760.2 12716.5 12775.400000000001 7826.699999999999 8639.6 True False 13359.360759002886 9434.436692445825 21819.633118435235 22073.084688915158 18019.189502933797 14611.72578918933 11757.284166887111 12436.554891652388 13281.338260449122 9748.576816830515 1.3703908796141917 0.9677757963765192 2.2382377990564266 2.2642366269101855 1.8483918054401964 1.4988573269446663 1.20605134347289 1.2757303066208792 1.3623874038228267 1.0 13.250975901558476 -7.025956039325195 3.4779499024897884 1.2376090384242255 1.7500772919492626 0.3118321350948161 0.36688913510802085 0.3558019578152094 8.979253937772842 0.16246252033871808 0.13014055089146598 9.419849424221786e-08 7.025956039325195 0.5124682535250371 EPEDEGEDDD ddPTM_A459_Selumetinib_30min_R2 1 EPEDEGEDDD 10 0 P39687 P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 146.54 0.011896 4572900.0 30575.0 28260.0 31021.0 33950.0 37500.0 27469.0 24939.0 30578.0 22286.0 32019.0 False True 28875.76390142257 30427.451129777994 29025.142633111063 29325.951432983347 32788.914745746464 31252.605411245004 26098.712915691016 30666.976917539607 26743.82272286735 31094.52827464713 0.9286445398487159 0.9785467996498587 0.9334485597189992 0.943122570439321 1.054491467313265 1.005083760563969 0.8393345827655008 0.9862499487584725 0.8600813135561499 1.0 14.924373110209187 -9.811556988950391 6.249970697221857 0.9999999966207579 0.9508025978541249 0.05999886813238331 0.06101694566329174 80455913.25816016 460898355.600966 0.05915558906418467 0.015273917656648735 1.5432738986919967e-10 9.811556988950391 -0.04919739876663298 EPEPAAGPQAEESATVSAPAPMS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 EPEPAAGPQAEESATVSAPAPMSPTR 26 0 Q9BWG6-2;Q9BWG6 Q9BWG6-2 SCNM1 Sodium channel modifier 1 1 EPEPAAGPQAEES(0.012)AT(0.091)VS(0.127)APAPMS(0.584)PT(0.185)R 92.238 1.6518e-05 6639700.0 2102.5 2331.7 2173.7 2020.2 1980.2 2027.8 2036.7 1821.5 1108.0 1832.7 True False 2151.484159247165 2058.703480022078 1878.5234792794222 1667.4099938506622 1801.0912596327048 2007.4021730950867 1883.0700792434234 1773.1879029341417 1880.1950748818317 2067.9448970097305 1.040397238030004 0.995531110620493 0.9084011290609273 0.8063125841804364 0.8709570850930802 0.9707232412226316 0.910599736949646 0.8574638064574107 0.9092094656877042 1.0 11.013982028404907 -5.174519088078178 3.1965361134389716 0.8965293301411582 1.0315262693896439 0.43867159836660685 0.05205267347375364 0.226569965608449 4.373390260533532 0.013994155846686396 0.04645165220501901 6.690844118521934e-06 5.174519088078178 0.13499693924848566 EPEPAAGPQAEESATVSAPAPMS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 EPEPAAGPQAEESATVSAPAPMSPTR 26 0 Q9BWG6-2;Q9BWG6 Q9BWG6-2 SCNM1 Sodium channel modifier 1 1 EPEPAAGPQAEESATVSAPAPMS(0.755)PT(0.245)R 165.23 3.1564e-16 6510600.0 19173.0 15904.0 18166.0 18849.0 24106.0 19124.0 20439.0 18745.0 21289.0 18950.0 True False 18107.441415600162 17123.78566057995 16997.219337645318 16281.73368366137 21077.58876962571 21758.157409612635 21389.45399911017 18799.544846598197 25547.39486435981 18402.864261987026 0.983946909449466 0.9304956781076116 0.9236181442013236 0.8847391064712103 1.1453428373736145 1.182324506656081 1.1622893966181258 1.0215553719770978 1.3882292723926966 1.0 14.167642707514949 -6.270422416837589 23.587430160215874 1.1532696998830558 0.9301795232591306 0.5305419124188022 0.1010116612904619 225.11225451054392 591092.9029187838 0.02941617724297777 0.03389048531834767 5.365097059574349e-07 6.270422416837589 -0.22309017662392527 EPES(ph)PPASAPIPLFGADTIGQR ddPTM_A459_Selumetinib_30min_R1 3 EPESPPASAPIPLFGADTIGQR 22 0 Q96AY4 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 EPES(1)PPASAPIPLFGADTIGQR;EPES(0.916)PPAS(0.084)APIPLFGADTIGQR;EPES(1)PPASAPIPLFGADTIGQR 253.52 8.1567e-45 27346800.0 4330.07 5166.299999999999 4563.6900000000005 5288.4 4852.2 4343.599999999999 3797.66 4641.5 2810.64 3891.59 True False 4430.952206150471 4561.427194252288 3943.9659645547713 4364.8802155627345 4413.31936672549 4299.907327673254 3511.1994486863923 4518.392342283185 4769.450798976415 4391.113483796638 1.0090725786297345 1.0387859960996484 0.8981699013492006 0.9940258277699482 1.0050570050195222 0.979229378502756 0.7996148270006778 1.0289855543374613 1.0861597671241827 1.0 12.100371104572908 -7.977857156079115 24.999957136533578 1.0479110286300153 0.9612762569629467 0.21961443211828113 0.06743820401353416 324.1109812571873 365931.1652072929 0.03766266677840573 0.01809097980713232 1.0523079318085892e-08 7.977857156079115 -0.08663477166706857 EPES(ph)PPASAPIPLFGADTIGQR ddPTM_A459_Selumetinib_30min_R2 2 EPESPPASAPIPLFGADTIGQR 22 0 Q96AY4 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 EPES(1)PPASAPIPLFGADTIGQR;EPES(0.985)PPAS(0.015)APIPLFGADTIGQR 132.23 2.1867e-05 5699500.0 17460.7 11798.0 10097.3 17320.7 16429.6 10178.9 12200.2 13773.5 12107.4 14713.9 True False 16490.30419472018 12702.868663450836 9447.650711109001 14961.590780125925 14365.566765512427 11580.951080145676 12767.533474237676 13813.578604674332 14529.21830902109 14289.071475696624 1.1540500880527815 0.8889918904147368 0.6611801702565426 1.047065290811453 1.0053534122175753 0.8104761110505313 0.8935173636686725 0.9667233191582093 1.0168063287900069 1.0 13.802624550641632 -7.9759666954066 4.17793887837498 1.0052330445176338 0.9154443420923379 0.06692043251501001 0.12626000318604563 0.5922206315669821 23.53710147564306 0.08291773429445173 0.034468265083070625 1.056898556126545e-08 7.9759666954066 -0.08978870242529591 EPFFHGHDNYDQLVR ddPTM_A459_Selumetinib_30min_R1 1 EPFFHGHDNYDQLVR 15 0 P68400;E7EU96;A0A2R8YD58;A0A2R8YFU2;A0A2R8Y5A0;A0A2R8YDP2;A0A2R8YF43;P68400-2 P68400;P68400-2 CSNK2A1 Casein kinase II subunit alpha 0 122.78 0.00085644 2782600.0 1007.6 1417.1 1050.4 1374.4 1048.5 1216.7 1090.9 1068.6 769.71 1343.2 False True 1031.0751195516962 1251.1852732080833 907.7614494341927 1134.386840683274 953.6633601277096 1204.4611026752111 1008.6125347113716 1040.2572566980089 1306.1416526058613 1515.61280387596 0.6803024604403387 0.8255309469597766 0.598940208945665 0.7484674435200362 0.6292262494014657 0.7947023801824427 0.6654816666446676 0.6863608264839818 0.8617911179330191 1.0 10.565685517540537 -8.491380038071437 2.966501974519333 0.9987210155521066 0.7050815092841758 0.6730959985769481 0.06671449000716552 0.1270292965144191 2.5712028644969873 0.05978610678050121 0.015995081705763227 3.225670199112981e-09 8.491380038071437 -0.2936395062679308 EPFPPS(ph)SPLQK ddPTM_A459_Selumetinib_30min_R1 1 EPFPPSSPLQK 11 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 EPFPPS(0.5)S(0.5)PLQK 129.34 0.0026033 4980000.0 2244.0 2619.0 2333.5 2332.5 1996.9 3085.3 5460.1 5886.4 3786.2 2302.2 True False 2296.280833936094 2312.3662624599333 2016.6235169979905 1925.1726614477127 1816.280747581329 3054.2646832282653 5048.2402610482695 5730.2735502780815 6424.904866893134 2597.709795327007 0.8839635736319928 0.8901557312597522 0.7763082391365168 0.7411038234181838 0.699185394322575 1.1757528453419046 1.943342659033544 2.2058944230745907 2.4732958540830188 1.0 11.343024552927456 -7.15254953710409 2.824538540370757 2.022352600756098 0.8028659298197908 0.6699090517072652 0.36340434069461763 0.14643274587763902 2.258903826343397 0.14860172548741915 0.1088356962426691 7.038019453168912e-08 7.15254953710409 -1.2194866709363072 EPFPPS(ph)SPLQK ddPTM_A459_Selumetinib_30min_R2 2 EPFPPSSPLQK 11 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 EPFPPS(0.5)S(0.5)PLQK;EPFPPS(0.912)S(0.088)PLQK 150.14 0.0023067 2474500.0 22172.0 19228.0 22840.7 22983.2 21531.5 18464.8 26202.0 42533.0 38730.0 47485.0 True False 20939.769001548382 20702.725772235357 21371.154229073847 19852.84851176857 18826.520475947742 21008.15859323443 27420.444918278026 42656.763988282786 46477.08220661635 46113.98466915328 0.45408717446088503 0.44894679826017925 0.46344193377349824 0.4305168736599898 0.4082605441932508 0.4555702298111592 0.5946231954364204 0.9250288018770343 1.0078739137393598 1.0 15.492916712704439 -7.699520344461026 2.220183662749916 1.0073542531560549 0.44204035921632 0.995528605977786 0.016070576725848565 0.02187407950142799 0.2148030748062882 0.012659670995677805 0.00568530186277902 1.997467195194515e-08 7.699520344461026 -0.5653138939397349 down EPFPPSS(ph)PLQK ddPTM_A459_Selumetinib_30min_R2 4 EPFPPSSPLQK 11 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 EPFPPS(0.193)S(0.807)PLQK;EPFPPS(0.205)S(0.795)PLQK;EPFPPS(0.184)S(0.816)PLQK;EPFPPS(0.298)S(0.702)PLQK 147.26 0.00066967 8318000.0 96487.5 87989.0 107826.0 101580.0 138098.0 114886.0 140335.0 173782.0 192862.0 225923.0 True False 91125.11102006584 94737.47337077254 100888.59255207205 87744.62876472592 120748.8946282159 130710.50366872808 146860.85556852698 174287.67684884125 231439.78901452257 219400.01597155145 0.4153377592820303 0.43180249076671307 0.45983858344455997 0.3999299105616444 0.5503595525894257 0.5957634191133181 0.6693748627054327 0.7943831547917495 1.0548758986623423 1.0 17.74320410520106 -7.636239723026413 0.8314709036817394 1.047051274632617 0.43070005525966254 0.9542656082138249 0.048778026607738875 0.11669049524655756 0.14932452318344994 0.04301538828255215 0.02017900808242809 2.310788922647061e-08 7.636239723026413 -0.6163512193729546 down EPGDVAT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 EPGDVATPPR 10 0 H3BT22;Q9Y5N6 H3BT22 ORC6 Origin recognition complex subunit 6 1 EPGDVAT(1)PPR 108.98 0.024196 17642000.0 26756.0 18028.0 24232.0 24226.0 30590.0 25429.0 29977.0 25336.0 29633.0 27190.0 True False 25269.00863275429 19410.6896308435 22672.93950180674 20926.37700781899 26747.01072193024 28931.613928521205 31370.98989829861 25409.723565399407 35560.42801519915 26404.954051895897 0.9569798373097321 0.7351154481349986 0.8586623350014428 0.792517077162513 1.012954261134561 1.0956888571614043 1.1880721260352334 0.9623089483685342 1.3467331904955873 1.0 14.688521010481255 -6.473554797179523 2.7105993767811025 1.1206619498268218 0.8296880996613448 0.5868893156364899 0.1115329239556536 0.18478676188247367 2.6961421120017426 0.03580278530499862 0.039454841423308185 3.3608196117354847e-07 6.473554797179523 -0.29097385016547694 EPGEQASVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EPGEQASVPLSPK 13 0 P42858 P42858 HTT Huntingtin 1 EPGEQAS(0.003)VPLS(0.997)PK 135.55 0.0015269 0.0 40474.0 26401.0 30808.0 31128.0 30687.0 28866.0 30405.0 34792.0 21370.0 29899.0 True False 38224.61711025929 28425.87180740512 28825.84682121417 26888.31270120489 26831.824714739254 32842.02948054161 31818.892746364527 34893.238959874354 25644.597127688907 29035.73818306861 1.31646789447044 0.9789960092690492 0.9927712751599052 0.9260419876937749 0.9240965235864226 1.131089875293494 1.0958527227979633 1.2017341780627222 0.8832080302557228 1.0 14.825542092064813 -6.788857840689227 24.998300211855703 1.07707754249786 1.0173848777892325 0.008128442930961821 0.1307332835293568 826.0959461501401 753172.8691997824 0.046114484191762097 0.04067737129626559 1.6260809400765376e-07 6.788857840689227 -0.05969266470862755 EPGGRS(ph)PAFVQLAPLSSK ddPTM_A459_Selumetinib_30min_R1 1 EPGGRSPAFVQLAPLSSK 18 1 P51610;A6NEM2;P51610-2;P51610-4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 EPGGRS(1)PAFVQLAPLSSK 65.438 0.018352 23906000.0 1997.0 1805.7 3154.4 3494.2 2682.5 2215.7 2122.4 1882.2 1260.6 1493.0 True False 2043.5262145144275 1594.2878045528448 2726.0498058789203 2884.0035642574903 2439.86834863384 2193.412069694636 1962.3056592459582 1832.2779417527536 2139.146129418806 1684.6410930515249 1.2130335790472886 0.9463664463182386 1.6181783865553279 1.7119394606678295 1.448301575152908 1.3020055599626468 1.1648211998031446 1.0876369746114898 1.2697933929321408 1.0 10.71822554762541 -7.1589307355206255 2.916165058117491 1.134038114308257 1.392642192080199 0.2560705243350567 0.20667447470667755 0.45306522012402545 7.437769846086962 0.09885568172606704 0.07241342183879979 6.935364074856525e-08 7.1589307355206255 0.25860407777194205 EPGGRS(ph)PAFVQLAPLSSK ddPTM_A459_Selumetinib_30min_R2 1 EPGGRSPAFVQLAPLSSK 18 1 P51610;A6NEM2;P51610-2;P51610-4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 EPGGRS(1)PAFVQLAPLSSK 77.469 0.007556999999999999 10911000.0 22983.0 31483.0 34873.0 35657.0 33152.0 19081.0 16069.0 18706.0 12040.0 26605.0 True False 21705.6968682386 33897.64486619959 32629.30914685154 30800.455088244107 28987.14937735966 21709.234549927758 16816.24034011944 18760.431363054984 14448.336425707756 25836.844521908457 0.8401063392177465 1.3119885765251227 1.2628983821605377 1.1921136523512668 1.1219307122733153 0.8402432631244626 0.6508627756713882 0.7261115554241541 0.55921443554983 1.0 14.657142262639454 -6.830718367949412 2.849345430519816 0.7125830884501347 1.1710151564172424 0.608019711432146 0.15790001294703557 0.16293145792555813 2.6872916568549834 0.05789131213892092 0.051639688714606564 1.476663812403372e-07 6.830718367949412 0.45843206796710767 EPGPIAPS(ph)TNSSPVLK ddPTM_A459_Selumetinib_30min_R1 1 EPGPIAPSTNSSPVLK 16 0 Q14674;Q14674-2 Q14674 ESPL1 Separin 1 EPGPIAPS(0.359)T(0.359)NS(0.238)S(0.043)PVLK 184.48 8.193e-07 12389000.0 1583.0 1944.8 1941.5 2142.4 1753.2 1713.7 1598.1 1617.9 791.88 1374.0 True False 1619.8808200181968 1717.1019118870088 1677.8549638961201 1768.2700578287581 1594.6233695526 1696.4617339151062 1477.5540303623088 1574.9880363201478 1343.7625233731271 1550.366283893365 1.0448374921765347 1.1075459584782301 1.0822313290267114 1.1405498663117086 1.0285462126718172 1.094232860672678 0.953035450856035 1.0158812486330335 0.8667387425367615 1.0 10.598393386308969 -7.302253249007007 1.6055979053184937 0.949124594620827 1.0887343586904485 0.594342671768211 0.04887036061519092 0.2557853657454838 1.2832731258922883 0.02636692095829654 0.015405130800325243 4.985936590549962e-08 7.302253249007007 0.13960976406962156 EPGPIAPSTNS(ph)SPVLK ddPTM_A459_Selumetinib_30min_R1 1 EPGPIAPSTNSSPVLK 16 0 Q14674;Q14674-2 Q14674 ESPL1 Separin 1 EPGPIAPS(0.028)T(0.028)NS(0.472)S(0.472)PVLK 142.54 0.00039411 12531000.0 2327.9 3272.3 3115.3 3632.7 3028.7 2474.1 3173.2 2944.9 1794.0 2741.7 True False 2382.135540695113 2889.1775947490037 2692.2593711179934 2998.317139224482 2754.7546197604147 2449.212800303064 2933.8429692420236 2866.7916856166653 3044.2869714241915 3093.623901419535 0.7700145902034343 0.9339136516960839 0.8702607223465748 0.9691925181495655 0.8904620301441208 0.7916970124193902 0.9483515329370857 0.9266775073405705 0.9840520594721599 1.0 11.59508210053829 -7.944560331053004 1.5047987687588678 0.9946902120590932 0.8806359453216474 0.37753439905489805 0.058477739606672394 0.47424967522497263 1.9373776823400146 0.05072058673275461 0.01746816643083736 1.1361604542666627e-08 7.944560331053004 -0.1140542667374459 EPGPIAPSTNSS(ph)PVLK ddPTM_A459_Selumetinib_30min_R2 1 EPGPIAPSTNSSPVLK 16 0 Q14674;Q14674-2 Q14674 ESPL1 Separin 1 EPGPIAPS(0.048)T(0.024)NS(0.299)S(0.629)PVLK 129.29 0.00088236 14692000.0 65016.0 54804.0 75561.0 70061.0 73626.0 56275.0 57814.0 76506.0 56010.0 83610.0 True False 61402.67099966933 59007.29057736564 70699.4875245964 60518.57093803377 64376.44365520869 64026.37043641241 60502.465556267634 76728.61979374982 67213.56505015703 81195.96205513125 0.7562281355565136 0.7267269096128237 0.8707266437288119 0.745339662296781 0.7928527727954959 0.7885413118566061 0.7451413102930791 0.9449807336681576 0.8277944290446326 1.0 16.309120362281462 -8.504134286216766 0.6210160367511259 0.999483617946031 0.7707952898832053 0.5917206016565046 0.05582293359926818 0.5713656572396024 0.5159913069138501 0.055518247608250706 0.023690763362360527 3.132317045089829e-09 8.504134286216766 -0.22868832806282569 EPGS(ph)PPSVQR ddPTM_A459_Selumetinib_30min_R2 1 EPGSPPSVQR 10 0 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 EPGS(0.997)PPS(0.003)VQR 87.641 0.033369 41076000.0 97857.0 63195.0 103840.0 113730.0 111630.0 99836.0 88780.0 92435.0 97172.0 93345.0 True False 92418.49969260857 68041.85329604823 97159.04745244341 98239.77780480681 97606.04141513794 113587.50277902563 92908.4459142327 92703.97054656208 116609.11521253125 90649.88731056356 1.01951036492727 0.7506005281941395 1.0718054962338748 1.0837275226635477 1.0767364892660354 1.2530352342290128 1.024915183798645 1.0226595233258404 1.2863680107293705 1.0 16.468017606065025 -5.413138232100457 6.572270608138195 1.106861347739096 0.8863688827110933 0.39643258634038625 0.10794911458553524 0.2167201170058482 11.2803270786608 0.027029116880302854 0.056790226365063416 3.8624401942459415e-06 5.413138232100457 -0.2204924650280028 EPGSGGPQNLS(ph)GPGGR ddPTM_A459_Selumetinib_30min_R1 3 EPGSGGPQNLSGPGGR 16 0 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 EPGSGGPQNLS(1)GPGGR;EPGSGGPQNLS(1)GPGGR;EPGSGGPQNLS(1)GPGGR 168.55 1.2851e-05 19860400.0 2263.8900000000003 2432.93 2151.54 2288.05 2513.6400000000003 2363.89 2210.94 2333.41 1542.76 2207.88 True False 2316.634232236889 2148.0814245615293 1859.3726855632542 1888.4850195178728 2286.281705819187 2340.11141284039 2044.167015761993 2271.5203868161157 2617.951041267775 2491.2829045724047 0.9298960900767343 0.8622390578842023 0.7463514810584672 0.7580371607141927 0.9177125976431797 0.9393198213440311 0.8205278541470371 0.9117874098710567 1.0508445413657712 1.0 11.282673144799148 -8.085633495425286 3.7132284749863973 1.0232897645678924 0.8520733845803559 0.5304252175254719 0.06382413225712684 0.20620855291839693 5.140017308274879 0.05279022730938429 0.01838298344360934 8.210441377379296e-09 8.085633495425286 -0.17121637998753658 EPGSGGPQNLS(ph)GPGGR ddPTM_A459_Selumetinib_30min_R2 2 EPGSGGPQNLSGPGGR 16 0 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 EPGSGGPQNLS(1)GPGGR;EPGSGGPQNLS(1)GPGGR 159.04 6.447399999999999e-05 20374600.0 10832.5 15596.7 17288.5 17967.0 13443.599999999999 11849.3 11465.4 11442.7 10493.6 12765.8 True False 10230.473015933283 16792.916738705186 16176.17673229556 15519.863605196226 11754.694780691121 13481.433517764219 11998.563818259101 11475.996362559035 12592.61321568163 12397.218184468291 0.825223277005031 1.3545713634163505 1.3048231056029724 1.2518827509739325 0.9481719693711491 1.0874563403791888 0.96784324029171 0.9256912471651586 1.015761199674467 1.0 13.5977288097009 -6.262144581752186 24.997628577878828 0.9907881372625345 1.2049211445243653 0.31040991201351487 0.13978015918184397 72.84667987894056 2582230.4388691233 0.0421150256624713 0.050663437735130656 5.46833885141678e-07 6.262144581752186 0.21413300726183082 EPHLNYS(ph)PTCLEPPVLSIHPGAID ddPTM_A459_Selumetinib_30min_R1 2 EPHLNYSPTCLEPPVLSIHPGAID 24 0 O75054;O75054-2 O75054 IGSF3 Immunoglobulin superfamily member 3 1 EPHLNY(0.436)S(0.53)PT(0.034)CLEPPVLSIHPGAID;EPHLNY(0.022)S(0.71)PT(0.268)CLEPPVLSIHPGAID 63.095 0.0029672 4409200.0 1062.78 957.22 1535.4099999999999 1085.48 1885.73 1283.92 1458.22 1539.32 385.78 758.79 True False 1087.5407061901071 845.1482374004948 1326.9097554034206 895.9212949831782 1715.166054452673 1271.004930506088 1348.2252913803418 1498.4922331839593 654.6404837436032 856.1880877404999 1.2702123771193221 0.9871058117975695 1.5497876861440179 1.0464071012101268 2.003258488422837 1.4844926584534706 1.5746835428863994 1.7501904717437904 0.7645989159592428 1.0 9.741783953039924 -5.265228148137968 24.87717150220794 1.4421174608933724 1.1286590918282167 0.07078594362390878 0.35943165730253024 618.0673533662273 4058279.0742368004 0.09006637834051033 0.19954174369749197 5.429650204712136e-06 5.265228148137968 -0.3134583690651558 EPHLNYS(ph)PTCLEPPVLSIHPGAID ddPTM_A459_Selumetinib_30min_R2 2 EPHLNYSPTCLEPPVLSIHPGAID 24 0 O75054;O75054-2 O75054 IGSF3 Immunoglobulin superfamily member 3 1 EPHLNY(0.059)S(0.704)PT(0.236)CLEPPVLSIHPGAID;EPHLNY(0.01)S(0.826)PT(0.164)CLEPPVLSIHPGAID 64.315 0.0020743000000000003 4402600.0 3487.7 1953.16 3966.4 3561.5 4297.0 2781.8900000000003 2686.75 5602.9 3616.8 3826.8 True False 3293.8675963693063 2102.961091600751 3711.2061422897923 3076.4175560698154 3757.1724443325993 3165.0700960169024 2811.689198694126 5619.203511389975 4340.261061835531 3716.3103407795224 0.8863273769753024 0.5658733794443119 0.9986265413752664 0.8278150299537458 1.0109953421017326 0.8516700183206461 0.7565808398295267 1.5120382842438576 1.167895214296105 1.0 11.859655267655187 -7.746198964638697 24.999847253699734 1.254975118223677 0.844178644567836 0.5254615329368405 0.16660928514126463 161.31506181955285 264616.50903011666 0.07615330997669377 0.043754297238061186 1.7939115884277935e-08 7.746198964638697 -0.41079647365584104 EPHS(ph)PADQPEQQAESTLTSAETR ddPTM_A459_Selumetinib_30min_R2 2 EPHSPADQPEQQAESTLTSAETR 23 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BS99 H3BSS6 ZNF106 Zinc finger protein 106 1 EPHS(1)PADQPEQQAESTLTSAETR;EPHS(1)PADQPEQQAESTLTSAETR 165.1 2.8679e-11 27644000.0 24964.0 25234.0 24821.0 32716.0 41017.0 24251.6 36783.0 39904.0 35053.0 25098.0 True False 23576.60081880993 27169.366659901552 23224.043883061448 28260.02436175208 35864.07776336753 27592.037765894245 38493.482384131756 40020.1140335372 42064.5794626523 24373.355527564658 0.9673104219132383 1.1147158883878254 0.9528455717472543 1.1594638386902392 1.4714460519318986 1.1320574114093347 1.5793263402159856 1.6419616079647747 1.725842771836649 1.0 14.573017262934323 -6.3596411162713045 0.9850868007510549 1.5105983711023443 0.9984223703656152 0.41330987442131484 0.21700747421513744 0.49355205873855396 1.0229744009335786 0.10331002025373706 0.14491004798454468 4.3687670068779327e-07 6.3596411162713045 -0.5121760007367291 EPHSFQSR ddPTM_A459_Selumetinib_30min_R2 2 EPHSFQSR 8 0 F8VQQ3;Q9HB07;H3BPH3;F8VR84 F8VQQ3 C12orf10 UPF0160 protein MYG1, mitochondrial 0 ; 185.55 0.001063 2604200.0 15951.3 12621.4 13288.099999999999 15598.4 17424.7 12246.9 10494.2 14749.0 12475.199999999999 16430.8 False True 15064.79060411323 13589.420795802547 12433.158112989357 13473.871011259142 15235.65340720555 13933.799308710764 10982.2010938628 14791.917148171615 14970.588586211736 15956.400111654702 0.944122138997365 0.8516595661120774 0.7791956848655395 0.8444179712827394 0.9548302437012273 0.8732420352466211 0.688263080457684 0.9270209473731773 0.9382184252998945 1.0 13.961847584563897 -7.982990044625689 24.999880073125233 0.9569461475886876 0.8473507716625297 0.31718382951817925 0.07332968712770115 291.21520081571055 428004.66476670146 0.04152964427734389 0.01994305997396223 1.0399440042925806e-08 7.982990044625689 -0.10959537592615787 EPIPEEQEMDFRPVDEGEECS(ph)DSEGSHNEEAK ddPTM_A459_Selumetinib_30min_R2 1 EPIPEEQEMDFRPVDEGEECSDSEGSHNEEAK 32 1 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9J7G1;B8ZZD2 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 EPIPEEQEMDFRPVDEGEECS(0.748)DS(0.229)EGS(0.023)HNEEAK 82.773 1.4038e-06 2633400.0 24890.0 18276.0 24455.0 29007.0 30191.0 30573.0 34899.0 37656.0 35360.0 24210.0 True False 23506.713442564465 19677.710433397824 22881.591924590775 25056.19656013396 26398.136669035506 34784.15323593846 36521.87265105659 37765.572725713624 42432.988040948985 23510.994394865756 0.9998179170038751 0.8369578122861094 0.9732294406734057 1.0657225355642823 1.12279966664448 1.4794845616370225 1.5533954896876714 1.606294148662667 1.804814689174327 1.0 14.521047938455432 -6.6252509160791995 1.6819615794175542 1.5497967755335498 0.9451146214132315 0.6024622160236764 0.1995410843996746 0.22163908670437554 1.2893591656152132 0.07689902183286261 0.07783453423367248 2.370004026875564e-07 6.6252509160791995 -0.6046821541203182 EPLIPAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 EPLIPASPK 9 0 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 EPLIPAS(1)PK 99.5 0.018752 38845000.0 6105.8 8452.2 8716.0 8536.5 6198.9 7065.7 7688.0 7497.7 4976.9 6956.0 True False 6248.053260181372 7462.6124946788195 7532.415073560955 7045.760524951084 5638.210589504684 6994.625473142303 7108.0879703556875 7298.836640038048 8445.435801605943 7848.870357177765 0.7960449052987031 0.9507880949841764 0.9596814230308425 0.8976782905463282 0.7183467598427792 0.8911633336822467 0.9056192352387838 0.9299219260722388 1.0760065356261899 1.0 12.938269314797456 -8.0215937109029 2.528655097890955 1.037080025297938 0.8751807273060184 0.4576608140397572 0.07000635564520037 0.2894226880545595 3.466644474568306 0.05916765274399041 0.020240988453739856 9.514945150165042e-09 8.0215937109029 -0.1618992979919196 EPLIPAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 EPLIPASPK 9 0 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 EPLIPAS(1)PK;EPLIPAS(1)PK;EPLIPAS(1)PK 111.94 0.0099843 56726100.0 807787.0 669745.0 729203.0 641133.0 572638.0 477620.0 610686.0 632403.0 431073.0 683170.0 True False 762893.4323675693 721112.2879304023 682286.8728761963 553809.579383885 500698.09499132674 543407.8195973212 639084.1090513519 634243.1880300473 517299.6451859722 663445.1070111712 1.149896840455142 1.0869208022032486 1.0283998866913158 0.8347481555464391 0.7546940804899115 0.8190697525005204 0.9632810646994355 0.9559844233192422 0.7797173266020664 1.0 19.339617577381347 -5.579355544416114 3.194283771163284 0.8675219676136785 1.1125037990547368 0.6248233907067298 0.07832334305644074 0.16328310289129772 3.3723831079687825 0.023172760627830948 0.04608469138579279 2.634173980278639e-06 5.579355544416114 0.24498183144105834 EPLPPFENQDIHS(ph)ASA ddPTM_A459_Selumetinib_30min_R1 3 EPLPPFENQDIHSASA 16 0 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 EPLPPFENQDIHS(0.878)AS(0.122)A;EPLPPFENQDIHS(0.885)AS(0.115)A;EPLPPFENQDIHS(0.5)AS(0.5)A 182.91 8.956200000000002e-07 29868100.0 2556.76 2707.51 3032.0699999999997 2929.71 3408.16 2448.7 2778.34 2719.5299999999997 1187.0900000000001 1855.6299999999999 True False 2616.3275334110717 2390.513470512749 2620.331547968328 2418.091145967836 3099.8925297595206 2424.0683012417103 2568.767576945633 2647.3992301215953 2014.4050283767817 2093.8181858668468 1.249548576409897 1.1417005959011046 1.2514608792947812 1.1548715940523457 1.4804974714058834 1.1577262618139592 1.2268341130498663 1.2643883064878265 0.9620725629254253 1.0 11.031920457715772 -8.262194014991268 24.996017319717843 0.9810362476620098 1.2398058141450052 0.5648077412973855 0.09123078432265291 48.327398809547795 1600604.175973923 0.07147627442201454 0.022629803706064266 5.467716457328632e-09 8.262194014991268 0.25876956648299543 EPLPPFENQDIHSAS(ph)A ddPTM_A459_Selumetinib_30min_R1 1 EPLPPFENQDIHSASA 16 0 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 EPLPPFENQDIHS(0.002)AS(0.998)A 268.17 2.3558e-50 25678000.0 3288.2 3746.0 3540.4 3602.4 3697.5 3241.3 3539.3 2711.8 1660.2 2586.9 True False 3364.8086622765873 3307.4165785318446 3059.633126025148 2973.308465423039 3363.0617778466444 3208.69546486493 3272.3277514932215 2639.874254832173 2817.238143789547 2918.953813539847 1.152744742540495 1.1330828748266162 1.0481951142333075 1.0186212784974749 1.1521462800290845 1.099262156866302 1.1210618463074735 0.9043905534191268 0.9651533815716843 1.0 11.511235667991414 -7.755197652999073 24.999776318229003 0.9510789664732551 1.101025035858735 0.6824541589755073 0.04590551234138482 84.13489525194929 336986.6196457374 0.02325148498250099 0.012990340161688749 1.7571237423637032e-08 7.755197652999073 0.14994606938547994 EPLS(ph)PSNSR ddPTM_A459_Selumetinib_30min_R1 1 EPLSPSNSR 9 0 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 EPLS(0.976)PS(0.024)NSR 102.05 0.01648 7642400.0 1020.7 1418.3 973.75 1523.2 2179.8 1066.2 1750.9 1210.2 867.43 1039.0 True False 1044.4803240635345 1252.2447766502187 841.5200984258803 1257.2017140052117 1982.6374748749486 1055.4749960321444 1618.8282033423231 1178.1015647163863 1471.9653554194472 1172.3657707170355 0.8909167685992022 1.0681348841192524 0.7177965439158077 1.0723630332846457 1.6911424099855281 0.9002949611763238 1.3808217910970098 1.0048924952797307 1.2555512896961947 1.0 10.19520703639508 -5.997568415969616 24.967499792153493 1.215801064754148 0.9074031904485764 0.2781897296171083 0.22525876242207643 96.46064481051434 990424.5912540266 0.0604786008534024 0.08909401622959345 1.0056146324380224e-06 5.997568415969616 -0.30839787430557153 EPLT(ph)ADEEEALKQEHQR ddPTM_A459_Selumetinib_30min_R2 1 EPLTADEEEALKQEHQR 17 1 Q9NRL2;Q9NRL2-2 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 EPLT(1)ADEEEALKQEHQR 80.859 0.0091496 2500300.0 19962.0 16106.0 18417.0 18067.0 18247.0 15600.0 13615.0 16710.0 11382.0 17058.0 True False 18852.591954217412 17341.27841104757 17232.070270913457 15606.2434326866 15954.648729750284 17748.758397299556 14248.124477610685 16758.62333351057 13658.718039651632 16565.49121799339 1.1380641664123898 1.0468315236080366 1.0402390152002272 0.9420936105857908 0.9631256036899402 1.0714296463494488 0.8601087821732937 1.011658701391686 0.8245284042537521 1.0 14.015893363967816 -1.5228787630214162 0.4153130802760128 0.9383532045858093 4.540395738164093 0.4375126536454623 0.06797511154606548 70.29468044986673 0.9085139486432083 0.04444265011816244 209.63348876822957 0.029999998774489726 1.5228787630214162 3.6020425335782833 EPPADVWT(ph)PPAR ddPTM_A459_Selumetinib_30min_R1 1 EPPADVWTPPAR 12 0 A0A3B3IUA7;Q14258 A0A3B3IUA7 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 EPPADVWT(1)PPAR 139.74 0.0026483 5684700.0 622.76 1131.9 907.5 1186.6 991.81 1021.4 891.16 809.11 395.71 613.61 True False 637.2690963199829 999.3766217939664 784.2664845406792 979.3825852406666 902.100960618278 1011.1256433569988 823.939083722968 787.6497744403205 671.4909684850991 692.3728205675462 0.9204132187014589 1.443408221851871 1.1327228066200037 1.4145306634622876 1.3029121505359138 1.4603774344119504 1.190022281705939 1.1376093212247624 0.9698401620310138 1.0 9.435405281894006 -7.916070039253178 2.0754042707838916 0.9884098455764967 1.2868252746912427 0.3503497968960525 0.1536159882081696 0.34999456615975333 2.84492109459306 0.11522372074125983 0.04159577814807638 1.2131931813970978e-08 7.916070039253178 0.29841542911474606 EPPADVWT(ph)PPAR ddPTM_A459_Selumetinib_30min_R2 1 EPPADVWTPPAR 12 0 A0A3B3IUA7;Q14258 A0A3B3IUA7 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 EPPADVWT(1)PPAR 132.06 0.0045307 3869300.0 11180.0 9925.6 14199.0 11324.0 13709.0 13420.0 12105.0 12924.0 9982.8 12884.0 True False 10558.660357086 10686.861604165757 13285.451798702288 9781.651665010417 11986.75285998502 15268.48318536925 12667.906485602452 12961.60670031662 11979.638942737152 12512.005443347802 0.8438823340425954 0.8541285929385197 1.0618163378250207 0.7817812827288195 0.9580201123040558 1.2203066290613687 1.0124601162427993 1.035933588664466 0.9574515449964346 1.0 13.611025424951947 -6.5288363821087945 24.994413712290477 1.0502875689434708 0.8925357351142897 0.3959497767197647 0.09298146796379514 162.05030936814555 679852.385275727 0.03035422110903791 0.03043472838940488 2.959127090297819e-07 6.5288363821087945 -0.157751833829181 EPPGLIFNKVEVS(ph)EDEPASK ddPTM_A459_Selumetinib_30min_R1 1 EPPGLIFNKVEVSEDEPASK 20 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 EPPGLIFNKVEVS(0.848)EDEPAS(0.152)K 51.398 0.036383 11344000.0 1388.7 1430.7 2656.4 2742.2 1706.0 2192.8 1711.4 1260.7 1210.7 1295.7 True False 1421.0540080601834 1263.1929788856148 2295.6754705607273 2263.3262474692046 1551.692601218764 2170.7424229031003 1582.3077201439548 1227.2621406692676 2054.4694739706083 1462.0157161867785 0.9719827169618729 0.8640077975223603 1.5702125805790212 1.5480861268525894 1.0613378392852577 1.4847599782065402 1.0822781880012353 0.8394315649835873 1.4052307722991273 1.0 10.513743104531684 -7.482122538165891 24.866398066499904 1.0655694880094282 1.254660183825753 0.08990932840711419 0.2606366986153757 1173.8515940082048 716198.5656442398 0.11369413765234855 0.07664129281781333 3.295167244151674e-08 7.482122538165891 0.18909069581632476 EPPS(ph)PSETGPNSLGTFK ddPTM_A459_Selumetinib_30min_R2 2 EPPSPSETGPNSLGTFK 17 0 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 EPPS(0.998)PS(0.002)ETGPNSLGTFK;EPPS(0.994)PS(0.003)ET(0.003)GPNSLGTFK 117.4 0.0017305 0.0 13906.8 13434.5 15151.8 19249.9 21993.8 17507.3 19660.6 24388.0 19156.4 15678.6 True False 13133.915729331273 14464.882951273969 14176.949684032501 16628.03041207029 19230.7422169333 19918.771659554033 20574.856856739818 24458.965042349253 22988.215274537215 15225.918080104999 0.8626025478550782 0.950017127057485 0.9311063943366977 1.0920872110692206 1.263026775512553 1.3082148186243672 1.351304844049045 1.6064032995362458 1.5098081543322401 1.0 13.8942416007636 -6.2146913874983625 1.1046698712690846 1.410500280547546 0.8881308157538843 0.6212446072930697 0.15055120544249373 0.3034660512220411 0.7675594581266721 0.0626059924340061 0.09890682626599742 6.099701920820861e-07 6.2146913874983625 -0.5223694647936616 EPPS(ph)SPLQPQK ddPTM_A459_Selumetinib_30min_R2 1 EPPSSPLQPQK 11 0 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 EPPS(0.5)S(0.5)PLQPQK 112.02 0.0079105 12936000.0 124920.0 92690.0 114540.0 101070.0 102730.0 94132.0 123450.0 111030.0 83828.0 94191.0 True False 117977.4464943814 99799.02495467503 107170.6211017225 87304.09164452509 89824.13898214747 107097.82855478226 129190.66961153437 111353.07891799406 100595.94235001887 91471.4610923918 1.2897732810369884 1.091040022350489 1.1716290504365465 0.9544407687589312 0.9819908626081699 1.1708332552664362 1.4123604025636352 1.2173532333272845 1.0997522194207743 1.0 16.481034075265832 -6.989086396606174 24.520207905348613 1.213496037959128 1.091827773757298 0.06921010886209489 0.13212522556389558 335.7496029312688 754343.1698085291 0.047581448052400346 0.041920058143616074 1.0254479079281305e-07 6.989086396606174 -0.12166826420183008 EPPSS(ph)PLQPQK ddPTM_A459_Selumetinib_30min_R1 2 EPPSSPLQPQK 11 0 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 EPPS(0.225)S(0.775)PLQPQK;EPPS(0.174)S(0.826)PLQPQK 152.96 0.00056908 35294000.0 12903.400000000001 15501.0 10091.1 11001.8 11416.400000000001 10598.6 14535.7 13651.9 7922.5 12697.0 True False 13204.024114354277 13686.135713780614 8720.784046444576 9080.54215936354 10383.78863572913 10491.987706758853 13439.260446240793 13289.807264379146 13443.903863493964 14326.783629253317 0.9216321301449322 0.9552832001898466 0.6087049453750343 0.6338158231706889 0.7247815632900929 0.7323337867220707 0.9380514701708537 0.927619737150437 0.9383755776169723 1.0 13.806427139676 -7.267921429398372 22.664244383188315 0.94498006805533 0.7569199901168843 0.43805961904370094 0.10423912399833835 160.70648477566198 561896.5639945159 0.04804839667076686 0.033367643409401904 5.396082371767634e-08 7.267921429398372 -0.1880600779384457 EPPSS(ph)PLQPQK ddPTM_A459_Selumetinib_30min_R2 2 EPPSSPLQPQK 11 0 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 EPPS(0.193)S(0.807)PLQPQK;EPPS(0.166)S(0.834)PLQPQK 134.56 0.0016055999999999998 85151000.0 259269.0 209664.0 242680.0 254011.0 239577.0 198249.0 251150.0 254779.0 232518.0 229543.0 True False 244859.86691604022 225744.5546239832 227066.23301000617 219414.26360658443 209479.19541444545 225556.0002247593 262828.9726442838 255520.3647090659 279028.09709574014 222915.49716566133 1.098442548990081 1.0126911654608717 1.01862022110226 0.9842934492953851 0.9397246852638935 1.01184530951267 1.1790520443222503 1.1462655937248456 1.25172139507366 1.0 17.766137391199898 -7.254435166510526 23.0920960792966 1.1564485614276405 1.0069173273897938 0.46770155998637997 0.0691128171371997 151.54691360809065 499634.57095675624 0.026034816673426768 0.019680788497826403 5.566277240179095e-08 7.254435166510526 -0.14953123403784674 EPPTIRPNS(ph)PYDLCSR ddPTM_A459_Selumetinib_30min_R2 1 EPPTIRPNSPYDLCSR 16 1 G3V1N5;B4E3L3;Q96RU2-2;Q96RU2 G3V1N5 USP28 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 28 1 EPPTIRPNS(0.645)PY(0.333)DLCS(0.021)R 59.63399999999999 0.041726 12865000.0 19153.0 22067.0 29407.0 31545.0 28632.0 18330.0 24761.0 22587.0 24200.0 23507.0 True False 18088.552935533822 23759.46794341157 27514.98563592072 27248.516581839755 25034.992186672327 20854.791116826993 25912.43556299068 22652.72443052085 29040.676204495652 22828.2918314791 0.7923743514874202 1.0407904419133291 1.205301992765788 1.1936292379207007 1.0966651544269421 0.9135502240281183 1.1351018181421133 0.9923092186548909 1.2721353143229919 1.0 14.47853529086624 -4.788731132154554 3.829056041426715 1.0997753417489298 0.7644361445041675 0.44179181319491 0.1036342358859846 0.22521325251827687 5.924902597957182 0.026058771840539452 0.20974627270586735 1.6265554300856626e-05 4.788731132154554 -0.33533919724476224 EPRPNS(ph)SPSPSPGQASETPHPR ddPTM_A459_Selumetinib_30min_R2 1 EPRPNSSPSPSPGQASETPHPR 22 1 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 EPRPNS(0.477)S(0.477)PS(0.046)PSPGQASETPHPR 114.71 8.915899999999999e-05 0.0 1060.6 822.86 2284.7 2846.7 3084.6 2553.6 1134.4 2257.8 3119.6 2346.2 True False 1001.6560979181945 885.9707160880795 2137.7048893932747 2458.9745491685917 2697.0849713261196 2905.3352207271905 1187.1518477709565 2264.369824201088 3743.6071689068012 2278.459109840315 0.439619957888292 0.38884644111527306 0.9382239427343049 1.079226982195405 1.1837320054056815 1.2751316045916707 0.5210327640482245 0.9938163096373432 1.6430433852153576 1.0 11.153842764259911 -5.345865774647398 3.2593369446436724 1.0830286927828405 0.4014012799851919 0.5100358241221965 0.2638785781924619 0.20617645924515327 4.174324707819802 0.073644366047753 0.18346695800826093 4.509560578732229e-06 5.345865774647398 -0.6816274127976487 EPRPNS(ph)SPSPSPGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R1 1 EPRPNSSPSPSPGQASETPHPRPS 24 2 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 EPRPNS(0.618)S(0.155)PS(0.222)PS(0.005)PGQASETPHPRPS 82.885 0.00018749 4387000.0 219.0 369.21 358.56 402.43 149.14 265.99 261.6 285.97 212.33 438.43 True False 224.10227390018025 325.9827215589277 309.8695214290976 332.1531550466893 135.65031333280558 263.3143820995968 241.8673013846316 278.38514663852675 360.3085020303781 494.7067611698462 0.4530002245577555 0.6589413105817833 0.6263700958853704 0.6714142217527772 0.27420347563479763 0.5322635604917352 0.4889104422439701 0.5627275964052362 0.7283274260864094 1.0 8.950429806755698 -8.574223779710026 1.988072042138177 0.9988218643875719 0.5329118092169388 0.6397689138785422 0.10932842147688929 0.2548209007393222 2.2844447116483866 0.10932479916586174 0.030522522888077993 2.665484861363365e-09 8.574223779710026 -0.4659100551706331 EPRPNSSPS(ph)PSPGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R1 3 EPRPNSSPSPSPGQASETPHPRPS 24 2 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 EPRPNS(0.001)S(0.003)PS(0.954)PS(0.041)PGQASETPHPRPS;EPRPNS(0.115)S(0.115)PS(0.755)PS(0.014)PGQASETPHPRPS;EPRPNS(0.022)S(0.12)PS(0.811)PS(0.047)PGQASETPHPRPS 103.85 1.6488e-06 106295400.0 3614.1 4426.79 3643.23 4480.63 6052.92 3975.73 5671.86 4238.49 1207.9 2921.6800000000003 True False 3698.3014981855745 3908.4993688411632 3148.4993768299064 3698.172082341892 5505.434454729824 3935.737765874019 5244.027033759316 4126.071476644153 2049.718078474516 3296.7060875731936 1.1218171714264062 1.1855771382150506 0.9550440024659927 1.1217779153203886 1.6699803708563365 1.1938394449871133 1.590686853622309 1.2515739550447704 0.621747290788478 1.0 11.68680955629225 -8.243183243285774 22.915440386558625 0.8108737920042891 1.266259965679002 0.3981598311144645 0.2214373155869477 245.95691423132405 308732.2680170661 0.1564184417936091 0.058767967967834886 5.712375616910488e-09 8.243183243285774 0.4553861736747128 EPRPNSSPS(ph)PSPGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R2 4 EPRPNSSPSPSPGQASETPHPRPS 24 2 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 EPRPNS(0.226)S(0.226)PS(0.308)PS(0.24)PGQASETPHPRPS;EPRPNS(0.047)S(0.069)PS(0.845)PS(0.039)PGQASETPHPRPS;EPRPNS(0.173)S(0.254)PS(0.566)PS(0.007)PGQASETPHPRPS;EPRPNS(0.045)S(0.037)PS(0.856)PS(0.062)PGQASETPHPRPS 84.025 4.9605e-05 111117000.0 37634.3 30714.0 63083.8 89276.0 93968.0 54882.2 38449.4 58153.8 52076.8 74778.1 True False 35542.73626803953 33069.66503892433 59025.05698844819 77116.45479030981 82162.89975542133 62441.7248789919 40237.37328604072 58323.01793012016 62493.61514736688 72619.06195616313 0.4894408618152502 0.45538546144932307 0.8128039029763144 1.0619312989316987 1.1314233142397154 0.8598530908686919 0.5540883096277147 0.8031364817866574 0.8605676452429456 1.0 16.14806067405094 -5.3147549659092 4.452668604195378 0.884664605796858 0.4689343208374204 0.5514639453290913 0.14997590589567253 0.16800692385221716 7.118055955599089 0.0452251466820088 0.1038088039412521 4.844456204477936e-06 5.3147549659092 -0.4157302849594376 EPRPNSSPSPS(ph)PGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R2 1 EPRPNSSPSPSPGQASETPHPRPS 24 2 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 EPRPNS(0.003)S(0.004)PS(0.126)PS(0.867)PGQASETPHPRPS 83.436 5.7519e-05 9740700.0 11426.0 9867.8 19237.0 25404.0 26717.0 15798.0 14967.0 12103.0 12988.0 20493.0 True False 10790.988661902025 10624.628530022053 17999.31236366194 21943.931375655662 23360.57160698956 17974.031100034514 15662.99515654786 12138.217726240484 15585.96291504089 19901.31384279157 0.5422249378681406 0.5338656841427777 0.9044283460803493 1.1026373207819113 1.1738205724267277 0.9031580146928272 0.7870332220413244 0.6099204214417759 0.7831625106845025 1.0 14.280576057148068 -5.262075529854179 21.43048682178546 0.9060375789709311 0.5380451206086869 0.48110438198854555 0.1536813721508237 7.210034197078689 243011.10149198258 0.046676444277375856 0.10767605967528741 5.4692083747763855e-06 5.262075529854179 -0.36799245836224415 EPS(ph)NPER ddPTM_A459_Selumetinib_30min_R2 1 EPSNPER 7 0 E7EX17;P23588;F8VX11;F8VP89;F8W0K0;F8VSC7;F8VRU1;F8VYE9 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 EPS(1)NPER 81.525 0.042863 5772700.0 17960.0 13563.0 21816.0 17948.0 21195.0 15437.0 24501.0 35813.0 20555.0 26496.0 True False 16961.855099576445 14603.238488081342 20412.38231146484 15503.45143797306 18532.294614295897 17563.306626866244 25640.345047810475 35917.2099008387 24666.574354686276 25730.99163512444 0.6591994331233794 0.5675350058466847 0.7932994810662735 0.602520558003286 0.7202324293245713 0.6825740288567509 0.9964771436484311 1.395873521322413 0.9586328698274821 1.0 14.651219437068457 -7.35612177195226 3.5730365442109027 1.1419868742066737 0.6691378389500762 0.7319509959485249 0.12444262159492989 0.1134181601629883 2.711231763335753 0.0527305011578358 0.0342210855413227 4.4043135352043886e-08 7.35612177195226 -0.4728490352565975 EPS(ph)PALGPNLDGSGLLPR ddPTM_A459_Selumetinib_30min_R1 4 EPSPALGPNLDGSGLLPR 18 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 EPS(1)PALGPNLDGSGLLPR;EPS(1)PALGPNLDGSGLLPR;EPS(1)PALGPNLDGSGLLPR;EPS(1)PALGPNLDGSGLLPR 145.17 0.00027625 57581100.0 2624.25 3730.2000000000003 2391.13 2613.94 2843.8500000000004 3012.58 2968.69 3280.9599999999996 1637.9299999999998 2514.385 True False 2685.3899190983925 3293.466449877067 2066.427679536919 2157.4644487308196 2586.6242696224986 2982.2761804037846 2744.75932319397 3193.9382827399418 2779.44758032599 2837.1308069339316 0.9465160762187329 1.1608440618345315 0.7283512182401254 0.7604388361149894 0.9117042694333316 1.0511592109588739 0.9674419369335364 1.1257634913885446 0.979668464186789 1.0 11.470216952780335 -6.721812904828732 7.0375241593310855 1.0290725873703384 0.8978469714509094 0.21747878827935907 0.11670936315684433 0.3353449448820166 45.109398890498284 0.04188751061172774 0.04134216690463992 1.8975232029939286e-07 6.721812904828732 -0.13122561591942894 EPS(ph)PALGPNLDGSGLLPR ddPTM_A459_Selumetinib_30min_R2 4 EPSPALGPNLDGSGLLPR 18 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 EPS(1)PALGPNLDGSGLLPR;EPS(1)PALGPNLDGSGLLPR;EPS(1)PALGPNLDGSGLLPR;EPS(1)PALGPNLDGSGLLPR 197.1 2.0037e-10 40661800.0 23388.4 13288.3 19567.2 18994.7 20799.4 17350.6 22479.199999999997 20935.8 16070.8 18454.6 True False 22088.56635918338 14307.469881381057 18308.267655156524 16407.589092314844 18186.393423004767 19740.487656934994 23524.52734168975 20996.71971189172 19285.409055669763 17921.76774719081 1.232499308704952 0.7983291650246788 1.0215659478137304 0.9155117577554084 1.0147656012256623 1.1014810556301995 1.3126231560152406 1.1715763761743259 1.0760885492834655 1.0 14.12942532689607 -6.803854038381157 3.443995839476104 1.1596165018802578 0.9799212735329379 0.2172124094769634 0.1264539272591144 0.29209996725330184 7.133834009608293 0.044329504381574965 0.040262592203301396 1.5708906747737672e-07 6.803854038381157 -0.17969522834731988 EPS(ph)PALGPNLDGSGLLPRPIFYCSFPTR ddPTM_A459_Selumetinib_30min_R1 1 EPSPALGPNLDGSGLLPRPIFYCSFPTR 28 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 EPS(1)PALGPNLDGSGLLPRPIFYCSFPTR 103.85 5.549800000000001e-08 53726000.0 0.0 0.0 0.0 0.0 0.0 60.78 117.98 0.0 0.0 138.76 True False 0.0 0.0 0.0 0.0 0.0 60.16860838382455 109.08067361375704 0.0 0.0 156.57119763685836 0.0 0.0 0.0 0.0 0.0 0.38428912400207815 0.6966841619666988 0.0 0.0 1.0 7.290675033002526 -14.522878745279803 0.2026447669957053 4.93386382502283 1.7294103437661413e-14 0.5941746877409368 0.22067876526734714 111.79612745443124 1.10559523873452 178.63637056899813 0.5639240896629107 3.0000000000036945e-15 14.522878745279803 -4.933863825022813 EPS(ph)PVRYDNLSR ddPTM_A459_Selumetinib_30min_R1 1 EPSPVRYDNLSR 12 1 Q9C0B5-2;Q9C0B5;Q9ULC8-2;Q9ULC8;Q9ULC8-3 Q9C0B5-2 ZDHHC5;ZDHHC8 Palmitoyltransferase ZDHHC5;Probable palmitoyltransferase ZDHHC8 1 EPS(0.992)PVRY(0.008)DNLSR 122.1 0.017211 10773000.0 1736.2 1459.4 2026.7 1155.9 2314.0 1582.2 1491.7 1895.3 826.44 1618.6 True False 1776.6500819428898 1288.5327695433475 1751.4852718662205 954.0437639302937 2104.699108569881 1566.2845045226593 1379.17986802544 1845.0304871979565 1402.4083192105957 1826.3630764991276 0.9727803331134298 0.7055184076614588 0.9590016872349189 0.5223735500386139 1.152399068757064 0.857597552577004 0.7551509805318268 1.0102210841529997 0.7678693997136694 1.0 10.834757882730862 -6.2718110369588365 24.999670251604197 0.9126341699676259 0.7959672762598226 0.13757003986000194 0.1625754177603879 1627.1964769187693 3922158.9561300753 0.04793473321386366 0.05492706503153966 5.347970008188194e-07 6.2718110369588365 -0.11666689370780337 EPS(ph)YFEIPTK ddPTM_A459_Selumetinib_30min_R1 2 EPSYFEIPTK 10 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 H0Y2V6;J3KQR7 CEP170;CEP170B Centrosomal protein of 170 kDa;Centrosomal protein of 170 kDa protein B 1 EPS(1)YFEIPTK;EPS(1)YFEIPTK 138.24 0.001659 8248100.0 3450.1 4330.799999999999 2474.01 2440.19 3149.5 3755.3999999999996 3955.1 3904.3 2671.7 2993.6 True False 3530.480617274027 3823.7479226657015 2138.053030764174 2014.0566245393768 2864.628281089388 3717.624085630381 3656.7636227307203 3800.745281046262 4533.679766752514 3377.8577201333196 1.045183340977039 1.1320038437009072 0.6329612458276626 0.5962526522460765 0.8480606699373723 1.1005863460358098 1.0825688722574118 1.1251940122854704 1.3421760602082364 1.0 11.721892845844291 -6.791067675976629 4.560979170790057 1.1394942827547225 0.8387410961863752 0.39905245835519687 0.17143704139072405 0.22678730562718658 10.926587904213415 0.06736120868907626 0.06144009333804346 1.617827912369223e-07 6.791067675976629 -0.3007531865683474 EPSAPSIPTPAY(ph)QSSPAGGHAPTPPTPAPR ddPTM_A459_Selumetinib_30min_R1 2 EPSAPSIPTPAYQSSPAGGHAPTPPTPAPR 30 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 EPSAPS(0.005)IPT(0.114)PAY(0.558)QS(0.168)S(0.153)PAGGHAPT(0.001)PPTPAPR;EPSAPS(0.002)IPT(0.019)PAY(0.591)QS(0.113)S(0.272)PAGGHAPT(0.002)PPTPAPR 72.028 0.0010614 42731000.0 3246.2999999999997 3247.3 3482.2 4069.1000000000004 3966.3999999999996 2875.45 3449.8 3668.5 1360.44 2547.79 True False 3321.9324737997954 2867.1046063711874 3009.3363663554337 3358.508071467048 3607.6398203247954 2846.525583699709 3189.578808550085 3571.199463032607 2308.567317393717 2874.8236640761866 1.1555256467764208 0.9973149456777275 1.0467898967022287 1.1682483741298586 1.2549082106864098 0.9901565856959887 1.1094867655387286 1.2422325263487763 0.8030291896652959 1.0 11.489257751409598 -8.266078371418008 24.999191617595077 0.9015145956111823 1.1153631212429402 0.449620139148872 0.09681229339841779 389.93041627388897 2101265.889496845 0.08346017594168613 0.024365207600129238 5.41903091447975e-09 8.266078371418008 0.21384852563175794 EPSAPSIPTPAY(ph)QSSPAGGHAPTPPTPAPR ddPTM_A459_Selumetinib_30min_R2 1 EPSAPSIPTPAYQSSPAGGHAPTPPTPAPR 30 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 EPSAPSIPT(0.02)PAY(0.709)QS(0.068)S(0.203)PAGGHAPTPPTPAPR 112.75 1.2567e-10 47076000.0 42218.0 47258.0 47097.0 58727.0 60796.0 46441.0 47513.0 43347.0 46754.0 53836.0 True False 39871.69257204443 50882.53664157991 44066.83029533644 50728.281290274346 53158.26295686405 52837.82620057624 49722.44864522339 43473.13259351785 56106.10641590866 52281.61479727355 0.7626331498491457 0.9732395764530478 0.8428743156883994 0.9702891061605042 1.016767809544326 1.0106387571512365 0.9510503613560227 0.8315185512553247 1.0731517500648153 1.0 15.674016081203849 -3.8716409201792974 0.9783057245495314 0.9671333700520902 1.495664696672447e-18 0.3965927984451717 0.07241864121504582 10.95943666553007 2.2303041710104567 0.023202940687070447 17.058585311126855 0.00013438756342047675 3.8716409201792974 -0.9671333700520902 EPSAPSIPTPAYQS(ph)SPAGGHAPTPPTPAPR ddPTM_A459_Selumetinib_30min_R1 2 EPSAPSIPTPAYQSSPAGGHAPTPPTPAPR 30 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 EPSAPSIPT(0.001)PAY(0.003)QS(0.97)S(0.026)PAGGHAPTPPTPAPR;EPSAPSIPT(0.009)PAYQS(0.744)S(0.246)PAGGHAPTPPTPAPR 139.11 2.6241e-18 39979000.0 3545.2 4100.1 4373.299999999999 4163.4 4830.1 3393.9 4246.7 3913.3 1563.94 3377.6 True False 3627.7962622416403 3620.0583859152243 3779.429880817358 3436.340346697279 4393.218307823417 3359.7604474146456 3926.3679999622154 3809.506571810142 2653.8919543417783 3811.1478606100645 0.9518907150616103 0.9498603880815446 0.9916775782644053 0.9016549534100762 1.1527283822360483 0.8815612960439788 1.0302323981032075 0.999569345283901 0.6963497747675841 1.0 11.896009865950662 EPSAPSIPTPAYQS(ph)SPAGGHAPTPPTPAPR ddPTM_A459_Selumetinib_30min_R2 1 EPSAPSIPTPAYQSSPAGGHAPTPPTPAPR 30 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 EPSAPS(0.001)IPT(0.027)PAY(0.329)QS(0.392)S(0.249)PAGGHAPT(0.002)PPT(0.001)PAPR 63.328 0.00063031 53273000.0 57473.0 54778.0 68957.0 79740.0 82775.0 56492.0 53004.0 62571.0 51439.0 72207.0 True False 54278.880742647925 58979.296460968806 64520.38169470482 68879.27444082734 72376.06448211108 64273.260216682516 55468.791025433486 62753.07125081333 61728.23732574589 70122.19629368313 0.7740613330951468 0.8410931142823016 0.9201135318763121 0.9822749155253178 1.0321420079169852 0.9165893770282905 0.7910304291257678 0.894910236239511 0.8802952643870141 1.0 16.097583562931312 -5.039998771418477 2.5957591506863418 0.9240142226731921 0.7744603279768999 0.37548139215664456 0.06440724888676394 0.38977493143677777 4.69233406550482 0.019103169057634036 0.0987019470162637 9.120134193593343e-06 5.039998771418477 -0.1495538946962922 EPSAT(ph)PPISNLTK ddPTM_A459_Selumetinib_30min_R1 3 EPSATPPISNLTK 13 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 EPS(0.003)AT(0.991)PPIS(0.006)NLTK;EPSAT(0.995)PPIS(0.005)NLTK;EPS(0.001)AT(0.989)PPIS(0.01)NLTK 131.96 0.0034415999999999995 42715000.0 11793.3 15593.1 12580.8 13760.199999999999 13707.5 12552.7 12655.8 12912.6 7425.8 11861.900000000001 True False 12068.06094423285 13767.452602964486 10872.396461387749 11357.239380944402 12467.65904525569 12426.431234939693 11701.162816756969 12570.11590196398 12601.040241026625 13384.490409690485 0.9016451560602913 1.0286123850480504 0.8123130674826471 0.8485373020045398 0.9315004653616845 0.9284201978988196 0.8742329710427547 0.9391553594646465 0.9414658201632664 1.0 13.708274591564551 -8.558671496540523 1.2396547781072251 0.9991856280515721 0.904959118091823 0.21994864270397718 0.05470097713640342 0.8512822591822891 2.853943076697505 0.053689023161706 0.01658131424356614 2.762666767034751e-09 8.558671496540523 -0.09422650995974913 EPSAT(ph)PPISNLTK ddPTM_A459_Selumetinib_30min_R2 3 EPSATPPISNLTK 13 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 EPSAT(0.999)PPIS(0.001)NLTK;EPS(0.357)AT(0.636)PPIS(0.006)NLTK;EPS(0.358)AT(0.64)PPIS(0.001)NLTK 156.96 0.00085376 78754900.0 297197.0 328484.0 366397.0 391263.0 411327.0 322878.0 343390.0 339024.0 298108.0 363895.0 True False 280679.98051385436 353677.66655746556 342823.4159228904 337972.3044336773 359652.4249499641 367351.51370533946 359358.31541437603 340010.5037115559 357737.9298334626 353388.40583724406 0.794253506559929 1.0008185348343168 0.9701037449451032 0.9563763237590007 1.0177255931695874 1.0395120712435773 1.016893337411532 0.9621439133126245 1.012308055172081 1.0 18.430895182363976 -4.76071047847402 24.99904325593241 0.9965750030934539 0.794253272974702 0.8512708266226258 0.025462136882016314 6.940550153981772 237878.89484796327 0.006891321220487006 0.04016156083461464 1.734960219988405e-05 4.76071047847402 -0.20232173011875187 EPSEVPT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EPSEVPTPK 9 0 P17096;P17096-3;P17096-2 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 EPS(0.012)EVPT(0.988)PK;EPS(0.004)EVPT(0.996)PK 132.03 0.008095100000000001 85373000.0 19237.9 27929.0 15812.1 18041.8 16041.8 18141.4 19644.1 17066.8 11643.1 19957.7 True False 19686.10563956291 24659.059696160144 13664.90366964814 14891.138316530472 14590.82202240983 17958.913987073283 18162.329721444356 16614.133023220653 19757.490321621528 22519.46519946042 0.8741817563249503 1.0950108929208047 0.6068040936414226 0.6612563035860759 0.6479204498497342 0.7974840356112715 0.8065169203875914 0.7377676546074787 0.8773516665082672 1.0 14.45888494572213 -9.960955382929523 15.05063508011575 0.9999999736711389 0.7842835785572598 0.17958282636974587 0.13466874203481743 0.0 0.0 0.13890204745390852 0.0336886948980601 1.094068759216526e-10 9.960955382929523 -0.21571639511387908 EPSQLWGCVPGELPS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 EPSQLWGCVPGELPSPGK 18 0 Q99612-3;Q99612-2;Q99612 Q99612-3 KLF6 Krueppel-like factor 6 1 EPSQLWGCVPGELPS(1)PGK 121.44 0.0011077 0.0 11697.0 11788.0 11133.0 10334.0 12903.0 13866.0 13686.0 12742.0 9766.3 11354.0 True False 11046.927566800976 12692.101695605914 10416.714900693898 8926.491372855677 11282.00978571644 15775.915636984353 14322.426118294525 12779.077110448343 11719.83289322173 11026.18051876521 1.0018816169389262 1.1510877836623035 0.9447255904223519 0.8095723952336786 1.023201984269697 1.4307688514745134 1.2989471824735237 1.158975865550171 1.0629095790038998 1.0 13.42864550584401 -6.547521510297076 24.994123911453734 1.2092611133164692 0.9781493291716744 0.3604684965783548 0.1359607001462987 243.64967930695107 247121.84464189634 0.04705391057727256 0.04705564719766848 2.8345132385863814e-07 6.547521510297076 -0.23111178414479483 EPST(ph)ASGGGQLNR ddPTM_A459_Selumetinib_30min_R1 1 EPSTASGGGQLNR 13 0 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 EPS(0.073)T(0.684)AS(0.243)GGGQLNR 99.161 0.027988 5423700.0 546.97 700.57 773.07 496.08 716.93 595.38 695.94 736.6 263.35 656.18 True False 559.7133367816508 618.5469387138429 668.0913401695462 409.44894057491143 652.0838080842718 589.3910177617879 643.444685495492 717.0629751859948 446.8857156770127 740.4070947344602 0.7559535028258834 0.8354146564947204 0.9023297384922422 0.5530051555242813 0.8807098320932963 0.7960364263840114 0.8690417610412784 0.9684712373578247 0.6035675763443136 1.0 9.532174909252772 EPST(ph)ASGGGQLNR ddPTM_A459_Selumetinib_30min_R2 2 EPSTASGGGQLNR 13 0 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 EPS(0.045)T(0.941)AS(0.014)GGGQLNR;EPS(0.039)T(0.948)AS(0.014)GGGQLNR 139.77 0.0021448 17735000.0 17234.7 14095.4 18136.5 15074.2 16807.4 14220.1 14339.4 12896.0 8890.1 10718.4 True False 16276.864369970503 15176.471856145534 16969.61733552814 13021.06795555458 14695.904151937568 16178.789697784583 15006.21051298205 12933.525224952273 10668.36841014821 10408.931942252339 1.5637401090018492 1.4580239298655238 1.6302938120523598 1.2509513971072246 1.4118551483926403 1.5543179441985795 1.4416666951263521 1.2425410500045646 1.0249244081270967 1.0 13.3455344212254 -8.01697748394562 2.0807518702519716 0.9995938687555098 1.4737445725161127 0.7866699893413801 0.096753193158942 0.15431338712767426 1.2191594780039892 0.08395271755180378 0.027908922144148536 9.616621345907597e-09 8.01697748394562 0.47415070376060287 EPSVPASCAVSATYERS(ph)PSPAHLPDDPK ddPTM_A459_Selumetinib_30min_R2 1 EPSVPASCAVSATYERSPSPAHLPDDPK 28 1 Q92615;H0Y4V9;H0Y641 Q92615 LARP4B La-related protein 4B 1 EPSVPAS(0.001)CAVS(0.029)AT(0.026)Y(0.023)ERS(0.757)PS(0.165)PAHLPDDPK 53.28100000000001 0.0053212 4186500.0 15679.0 15489.0 17170.0 21233.0 19821.0 16134.0 13367.0 11639.0 15128.0 20702.0 True False 14807.623948009965 16676.95649501527 16065.300893282507 18341.028771031975 17330.908778011755 18356.312050130204 13988.591986208014 11672.867563059826 18154.02271163678 20104.279469744364 0.7365408927136373 0.8295227153061122 0.7990985659277042 0.9122947578715285 0.8620507292536222 0.9130549581622789 0.6958017076543298 0.5806160614025851 0.9029929542591867 1.0 14.295215010934967 -9.36489335221463 12.394673575782047 1.0000062872519149 0.8025988095063723 0.2509805949263664 0.1017988384822303 0.0 0.0 0.10421911386913482 0.02527684792298338 4.31625056081018e-10 9.36489335221463 -0.19740747774554257 EPTGVEENKTDSLFVLPSRDDAT(ph)PVRDEPMDAESITFK ddPTM_A459_Selumetinib_30min_R1 1 EPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK 38 3 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 EPTGVEENKT(0.004)DS(0.047)LFVLPS(0.184)RDDAT(0.761)PVRDEPMDAES(0.003)ITFK 57.417 8.8171e-05 11054000.0 922.55 1343.7 1085.0 1144.5 1048.6 1177.8 889.82 743.02 414.94 1040.8 True False 944.0436200301881 1186.3789793308179 937.6629594783886 944.634559925791 953.754315145366 1165.9524013568373 822.7001610018078 723.3126959308955 704.1228739814685 1174.3968182505198 0.8038540341385758 1.0102028214774523 0.7984208956519571 0.8043572200178455 0.8121227002012477 0.9928095710389764 0.7005299641626849 0.6159014437797975 0.599561292264389 1.0 10.197704249321301 -7.336086533685821 11.521989448907972 0.6967837483177336 0.8677221185937876 0.21475625028192225 0.1264445770489847 1.146217871401151 174.43450526891473 0.05092960044031924 0.034321820542239014 4.612256656483776e-08 7.336086533685821 0.17093837027605396 EPTPS(ph)IASDISLPIATQELR ddPTM_A459_Selumetinib_30min_R2 1 EPTPSIASDISLPIATQELR 20 0 A0A499FIX8;H7BXI1;A0A087WXU3;A0FGR8-5;A0FGR8-2;A0FGR8;A0FGR8-6 A0A499FIX8 ESYT2 Extended synaptotagmin-2 1 EPT(0.008)PS(0.495)IAS(0.169)DIS(0.328)LPIATQELR 149.42 1.6475e-05 20509000.0 2655.9 3931.1 2317.0 2369.7 917.0 974.83 3314.8 2886.3 2179.1 2554.7 True False 2508.2957104100815 4232.602729521239 2167.926742558856 2046.9427720394892 801.7982619159865 1109.1039838743293 3468.944768151591 2894.6986551473115 2614.9808891411744 2480.9391730922566 1.011026686028633 1.7060485704071893 0.8738330895298573 0.8250676978461218 0.32318336161245764 0.447050051006263 1.39823854037819 1.166775343201721 1.054028618477513 1.0 11.276670648770336 -7.290587153617336 24.990547197009988 1.1686585119515893 0.8766707918723199 0.13429487813660212 0.359695526768065 1774.317337035203 1521246.3795883083 0.17098845754414102 0.11530104299919047 5.121684786872971e-08 7.290587153617336 -0.29198772007926943 EPTPSIAS(ph)DISLPIATQELR ddPTM_A459_Selumetinib_30min_R1 1 EPTPSIASDISLPIATQELR 20 0 A0A499FIX8;H7BXI1;A0A087WXU3;A0FGR8-5;A0FGR8-2;A0FGR8;A0FGR8-6 A0A499FIX8 ESYT2 Extended synaptotagmin-2 1 EPTPSIAS(1)DISLPIATQELR 261.66 1.0574e-47 8376200.0 792.56 856.23 788.09 834.01 1081.1 856.43 821.37 775.42 191.6 759.06 True False 811.0251059466973 755.9821935494718 681.0717066685008 688.3658098066485 983.3146958837076 847.8150917762227 759.4133996112191 754.8533426808631 325.1312060896741 856.4927448705228 0.9469141575382535 0.8826486833391155 0.7951867785773941 0.8037030248408114 1.148071249608024 0.9898683869229834 0.8866547955710012 0.8813306910089184 0.3796076593022684 1.0 9.74229721543759 -8.02981258850477 24.919397128959282 0.670025525529422 0.919521638350783 0.22722671437503694 0.16806920703624542 880.8145854736279 736239.4782574475 0.10860723178610927 0.041189082637509804 9.336571157868121e-09 8.02981258850477 0.24949611282136108 EPTPSIAS(ph)DISLPIATQELR ddPTM_A459_Selumetinib_30min_R2 1 EPTPSIASDISLPIATQELR 20 0 A0A499FIX8;H7BXI1;A0A087WXU3;A0FGR8-5;A0FGR8-2;A0FGR8;A0FGR8-6 A0A499FIX8 ESYT2 Extended synaptotagmin-2 1 EPTPSIAS(0.968)DIS(0.032)LPIATQELR 201.14 8.839399999999997e-16 20468000.0 5251.3 2157.5 5567.6 5438.4 5469.6 3471.0 7671.2 4519.7 5768.4 6104.1 True False 4959.453768619473 2322.9733125440907 5209.386677544536 4697.680538236721 4782.4599491555955 3949.098743399152 8027.926000194429 4532.8515787233855 6922.241182562509 5927.858772643536 0.8366349400068109 0.3918739298014952 0.8787973663585449 0.792475110897722 0.8067769716826184 0.6661931221478893 1.3542707928944746 0.7646692933445097 1.1677473178861726 1.0 12.533295361449918 -7.228188925106463 24.993868449727714 1.0520610780485415 0.7267353149925937 0.4437416182217355 0.18754870969814277 605.8392606910555 455400.9044233455 0.06878874719413679 0.05328014863326803 5.91304351285612e-08 7.228188925106463 -0.32532576305594785 EPTPSIASDIS(ph)LPIATQELR ddPTM_A459_Selumetinib_30min_R2 1 EPTPSIASDISLPIATQELR 20 0 A0A499FIX8;H7BXI1;A0A087WXU3;A0FGR8-5;A0FGR8-2;A0FGR8;A0FGR8-6 A0A499FIX8 ESYT2 Extended synaptotagmin-2 1 EPTPSIAS(0.125)DIS(0.873)LPIAT(0.002)QELR 148.19 3.7335e-06 0.0 2152.5 1302.0 3382.0 2606.9 2689.5 2186.9 3989.5 2350.8 3478.4 2318.6 True False 2032.8726671402176 1401.859213410153 3164.405802043184 2251.8357228466657 2351.620965564937 2488.1256242983604 4175.019655044278 2357.6404388041087 4174.177194616431 2251.655993553728 0.9028344795830865 0.622590314605579 1.4053682316937266 1.0000798209377686 1.0443962009727057 1.1050203190103738 1.8541996055334176 1.0470695548315567 1.8538254540510157 1.0 11.136770714964754 -7.023639808420424 22.664117581262627 1.4479697246540553 1.0051629503913053 0.3052016689784389 0.3177580369841647 282.77598340192645 271103.62584955175 0.11461856354319222 0.08950912264843316 9.470222692755131e-08 7.023639808420424 -0.44280677426274995 EPTTCHTVKLRGAPFNVT(ph)EK ddPTM_A459_Selumetinib_30min_R1 1 EPTTCHTVKLRGAPFNVTEK 20 2 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 1 EPTTCHTVKLRGAPFNVT(0.999)EK 40.179 0.040239 2120100.0 678.67 641.92 570.04 501.07 686.1 539.56 721.11 632.22 436.33 427.24 True False 694.4816905380607 566.7637079794883 492.63169900558546 413.5675307488127 624.0423761407932 534.1325162812825 666.7160921310082 615.4514718600182 740.4201417176802 482.08041567001555 1.4405930379329783 1.175662170784881 1.0218869777584831 0.8578807960369418 1.294477759013448 1.1079738958881429 1.3829976710511631 1.2766572792728739 1.5358851296388243 1.0 8.913130011772633 -7.255470696783618 24.492270960417482 1.3219397938684665 1.1384241594376525 0.12137973589275641 0.1911686582965184 675.807781932395 2773161.263819833 0.07459399598681585 0.05621616516497257 5.55302083835914e-08 7.255470696783618 -0.18351563443081398 EPVAES(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 EPVAESPK 8 0 A0A0G2JNN3;C9JMY0;A0A087WUE4;Q96PV6-1;Q96PV6 A0A0G2JNN3 LENG8 Leukocyte receptor cluster member 8 1 EPVAES(1)PK;EPVAES(1)PK;EPVAES(1)PK;EPVAES(1)PK 129.88 0.003963800000000001 192368000.0 21956.7 28676.5 27577.9 28591.699999999997 19171.3 24519.199999999997 21826.5 21879.9 17096.3 24516.600000000002 True False 22468.248389699016 25319.042048656847 23832.97265456134 23598.69632768041 17437.25929996792 24272.55910965237 20180.10953238403 21299.573976068485 29011.172435651864 27663.544421906914 0.812197021720264 0.9152493860695073 0.8615299721205602 0.8530611973566363 0.6303335188732814 0.8774204324457714 0.7294838732379966 0.7699510102979152 1.048714943869512 1.0 14.755698394761872 -8.26349739534891 24.998937074538755 1.0243575001640044 0.8071585848851891 0.5529654252290814 0.07847323166932303 143.25780591747665 1740101.628435844 0.0662518900265996 0.020423846618829976 5.451331650775257e-09 8.26349739534891 -0.2171989152788153 EPVAES(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 EPVAESPK 8 0 A0A0G2JNN3;C9JMY0;A0A087WUE4;Q96PV6-1;Q96PV6 A0A0G2JNN3 LENG8 Leukocyte receptor cluster member 8 1 EPVAES(1)PK;EPVAES(1)PK;EPVAES(1)PK;EPVAES(1)PK 119.34 0.007927600000000002 151266000.0 1468120.0 1368790.0 1245840.0 1106900.0 1100390.0 847866.0 1187490.0 1076650.0 724361.0 1070000.0 True False 1386527.7677500092 1473771.7916464538 1165684.0107680317 956138.310490995 962149.1705885853 964651.8453387679 1242710.637966796 1079782.8732509986 869253.440337381 1039106.3198061271 1.3343463910494768 1.4183070235983408 1.121813993957347 0.9201544560612315 0.9259391000221227 0.9283475876835676 1.1959417571424806 1.0391457088360898 0.8365394606584274 1.0 19.986911845519728 -5.429232351587658 3.506875145379933 0.9853996484781706 1.3749923065557168 0.7420817821235117 0.09272089548843321 0.12382455067177961 2.8178787720125635 0.026694328629393107 0.0602741069768105 3.721925265139645e-06 5.429232351587658 0.3895926580775462 EPVAES(ph)PKK ddPTM_A459_Selumetinib_30min_R1 1 EPVAESPKK 9 1 A0A0G2JNN3;C9JMY0;A0A087WUE4;Q96PV6-1;Q96PV6 A0A0G2JNN3 LENG8 Leukocyte receptor cluster member 8 1 EPVAES(1)PKK 107.09 0.022966 19914000.0 3423.1 4542.6 4275.9 4471.7 2872.3 3564.2 3308.1 3301.8 2529.4 3502.2 True False 3502.8515698068804 4010.750280202554 3695.2562658374545 3690.8015392050334 2612.5009721457523 3528.3473840346724 3058.56735363341 3214.2255382420813 4292.207059933308 3951.741484316846 0.8864070647608249 1.0149323522603628 0.9350956484635201 0.933968366567652 0.6611011834943921 0.8928588567945336 0.7739796152587035 0.8133693843583338 1.086155832047126 1.0 11.948272856206902 -6.028850346436537 24.98159464533644 0.8526214594120682 0.9494418807588912 0.07231066074467207 0.11434652201901942 1397.3498038878 1209967.006947932 0.03310922215731645 0.042830288842187474 9.357280611914904e-07 6.028850346436537 0.096820421346823 EPVRADS(ph)PVHMEQQSR ddPTM_A459_Selumetinib_30min_R1 2 EPVRADSPVHMEQQSR 16 1 O95402 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 EPVRADS(1)PVHMEQQSR;EPVRADS(1)PVHMEQQSR 89.604 0.007162300000000002 15460400.0 3579.1000000000004 4191.2 4414.4 5244.299999999999 4492.8 3628.0 4488.7 4065.0 2374.7 3009.1000000000004 True False 3662.486066283723 3700.4923555639803 3814.948726563498 4328.481452703208 4086.4270332682668 3591.505613960438 4150.1137451269 3957.182995019098 4029.6924587742656 3395.347296116103 1.078677892677782 1.0898715309025764 1.1235812993054854 1.2748273078440329 1.2035372752421178 1.0577726814775967 1.2222943290290702 1.1654722330012228 1.1868277696905358 1.0 11.72934343402422 -5.5278544165030015 24.998153761759298 1.1684492263553468 1.089887614969052 0.12650898034557279 0.07519540770605701 223.87977214145775 1124785.032495052 0.01976593417906714 0.03439292641078665 2.9658254221289817e-06 5.5278544165030015 -0.0785616113862948 EPVRADS(ph)PVHMEQQSR ddPTM_A459_Selumetinib_30min_R2 1 EPVRADSPVHMEQQSR 16 1 O95402 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 EPVRADS(1)PVHMEQQSR 82.859 0.010664 9666800.0 4802.7 9706.6 10642.0 15593.0 17060.0 8402.4 15141.0 11512.0 4599.6 13497.0 True False 4535.785160731388 10451.065008361757 9957.305306133512 13469.206500574646 14916.770281664922 9559.75433060704 15845.086501322316 11545.498014085808 5519.6485235619075 13107.306540582527 0.34605013216771874 0.7973465010529371 0.7596759315351284 1.0276105513265912 1.1380500055812364 0.7293454456877436 1.2088743367878931 0.8808444342351279 0.42111233963073225 1.0 13.678083631869335 -4.631185760901742 1.6266888673013833 0.913868975609246 9.476068269971933e-17 0.3707955837006417 0.21380403390281422 1.6728735207240357 3.217560500959198 0.059638056147233824 2.7148368738590207 2.337837061063248e-05 4.631185760901742 -0.9138689756092458 EPVS(ph)PMELTGPEDGAASSGAGR ddPTM_A459_Selumetinib_30min_R1 2 EPVSPMELTGPEDGAASSGAGR 22 0 K7EQ54;A0A0C4DFL8;F5GX28;O94953 K7EQ54 KDM4B Lysine-specific demethylase 4B 1 EPVS(0.999)PMELT(0.001)GPEDGAASSGAGR;EPVS(0.981)PMELT(0.019)GPEDGAASSGAGR 94.564 0.00022964 7078600.0 449.248 360.94 641.84 664.39 578.36 485.826 558.13 490.59 365.336 536.91 True False 459.7146043155624 318.6809770035465 554.6816533747549 548.3667586449071 526.0474401177512 480.9390315347144 516.0298047469593 477.57795953909425 619.9485089142858 605.8276284462787 0.7588207977482943 0.5260258232541226 0.9155766877078648 0.9051531044420387 0.8683120666960438 0.7938545700996554 0.8517766118893962 0.7883066686210781 1.0233084128305965 1.0 9.242763562747125 -2.7559855657587793 0.22203843145384047 0.9631342623218903 4.2393839730026776e-32 0.3881821012886997 0.10493379540428757 34.1191442246892 0.7034644839448952 0.17313505119235834 10.545769174962599 0.0017539387949032587 2.7559855657587793 -0.9631342623218903 EPVS(ph)PMELTGPEDGAASSGAGR ddPTM_A459_Selumetinib_30min_R2 2 EPVSPMELTGPEDGAASSGAGR 22 0 K7EQ54;A0A0C4DFL8;F5GX28;O94953 K7EQ54 KDM4B Lysine-specific demethylase 4B 1 EPVS(1)PMELTGPEDGAASSGAGR;EPVS(1)PMELTGPEDGAASSGAGR 159.26 4.2603e-09 7063100.0 15591.7 13450.0 17473.4 16889.7 19612.0 12343.4 16629.1 18717.8 15298.5 16996.6 True False 14725.175732520369 14481.571751433614 16349.180467599463 14589.293723642388 17148.165226495446 14043.591307770992 17402.38609993652 18772.265699101405 18358.62747580481 16505.86399552975 0.8921178398482114 0.8773592073311417 0.9905074022194341 0.8838854923070719 1.038913517713441 0.8508243683320297 1.0543153696558734 1.13730888029766 1.112248803260274 1.0 14.010691037615633 -7.426008463726852 5.609517578714494 1.0941392858175552 0.9274014098484802 0.5918040134621498 0.06252828179557095 0.14735036131303353 6.844784945838733 0.02559660715309611 0.016930313109623098 3.749656946736046e-08 7.426008463726852 -0.16673787596907497 EPYGHLGPAELLEAS(ph)PAAR ddPTM_A459_Selumetinib_30min_R1 4 EPYGHLGPAELLEASPAAR 19 0 Q9H6W3 Q9H6W3 NO66 Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 1 EPYGHLGPAELLEAS(1)PAAR;EPYGHLGPAELLEAS(1)PAAR;EPYGHLGPAELLEAS(1)PAAR;EPYGHLGPAELLEAS(1)PAAR 155.11 2.5253e-06 16857300.0 6869.099999999999 8093.6 7922.199999999999 7991.9 7735.900000000001 6921.5 7286.3 7539.6 4622.4 6465.269999999999 True False 7029.1366650581185 7145.99754938744 6846.408753529661 6596.264691542973 7036.1892108840775 6851.875994219176 6736.688524766217 7339.6253159276675 7843.87519326153 7295.150381562783 0.9635355403807757 0.9795545226110347 0.9384876795456831 0.9041985903695527 0.9645022847872767 0.9392371144995304 0.9234475195730055 1.0060965068625984 1.0752177519308652 1.0 12.832722002695412 -7.929268750924357 4.736908940271957 1.0389251527678534 0.9451134999716485 0.6787748386361205 0.02650514465467105 0.11136008028907522 4.7020545150920885 0.015673125608060726 0.007085461209608496 1.1768774706176282e-08 7.929268750924357 -0.09381165279620485 EPYGHLGPAELLEAS(ph)PAAR ddPTM_A459_Selumetinib_30min_R2 2 EPYGHLGPAELLEASPAAR 19 0 Q9H6W3 Q9H6W3 NO66 Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 1 EPY(0.018)GHLGPAELLEAS(0.982)PAAR;EPY(0.06)GHLGPAELLEAS(0.94)PAAR 100.39 0.00084451 6386600.0 42525.0 39849.0 42380.0 50779.0 51628.0 39565.0 45727.0 43975.0 41752.0 43921.0 True False 40161.6307410628 42905.29016526973 39653.316939855125 43862.8126013391 45142.02907982396 45014.719614689595 47853.39610633156 44102.95996954686 50103.56664835134 42652.886609537316 0.9415923266511705 1.0059176195515915 0.929674872954285 1.0283668020614398 1.0583581245760296 1.0553733449924152 1.121926319885496 1.0339970744133715 1.174681730383707 1.0 15.380355761335487 -6.103849230704635 1.900529844726494 1.080547392055358 0.9629698704775072 0.5161161617416758 0.049168902201504674 0.26144163832876127 1.8716238263214602 0.01534341501188521 0.0227178463195843 7.873190672609408e-07 6.103849230704635 -0.11757752157785095 EQAEAEVASLNRR ddPTM_A459_Selumetinib_30min_R2 1 EQAEAEVASLNRR 13 1 P06753-2;A0A087WWU8;P06753-5;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0 P06753-2 TPM3 Tropomyosin alpha-3 chain 0 115.12 0.0055023 4402900.0 19067.0 17878.0 19217.0 21540.0 20727.0 14560.0 13456.0 11757.0 12941.0 18494.0 False True 18007.33247124854 19249.185113169522 17980.59914188759 18606.21484142743 18123.088958268974 16565.50783747959 14081.73066255816 11791.210923523868 15529.561601751167 17960.030166817323 1.0026337541747905 1.0717791080737726 1.0011452639488474 1.0359790417169783 1.009078982047197 0.9223541209906077 0.7840594103552984 0.6565251179426819 0.8646734697831047 1.0 14.132502152873565 -6.996646502902953 2.6368514721250396 0.7986389021316079 1.0270378653914887 0.547031788603008 0.08325026325854887 0.18477276058972836 2.590873633054512 0.03295848219915011 0.026447797135428823 1.0077516017291205e-07 6.996646502902953 0.22839896325988074 EQAPDIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 EQAPDISPK 9 0 Q7Z333-3;Q7Z333;Q7Z333-4 Q7Z333-3 SETX Probable helicase senataxin 1 EQAPDIS(1)PK 89.46 0.02984 8328300.0 2956.8 6664.1 4936.6 5261.7 2987.8 4316.6 3936.6 3171.2 2654.5 3813.0 True False 3025.687687068733 5883.864073943965 4266.236834802774 4342.842869341664 2717.5540175389347 4273.178923159213 3639.6590926251565 3087.0894744906673 4504.492622990815 4302.435691765212 0.7032499504547731 1.367565838393722 0.991586426955382 1.009391698208015 0.6316315250778266 0.9931999521429231 0.8459531654572784 0.717521352009817 1.0469633820703785 1.0 12.070937913216984 -6.025310749111609 24.069151662172068 0.8592502475094053 1.046312644593647 0.11475087131285733 0.19208175281158407 788.0434756714942 749386.5496959152 0.053557740793875964 0.06947856197061783 9.433856175380207e-07 6.025310749111609 0.18706239708424177 EQDNSESPNGRTS(ph)PLVSQNNEQGSTLR ddPTM_A459_Selumetinib_30min_R1 1 EQDNSESPNGRTSPLVSQNNEQGSTLR 27 1 A0A1W2PNZ9;Q15652-3;Q15652;H7BXU7 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 EQDNS(0.016)ES(0.016)PNGRT(0.096)S(0.871)PLVS(0.001)QNNEQGSTLR 76.109 7.5884e-05 6489300.0 268.24 302.98 533.96 470.86 577.58 341.93 495.24 355.96 238.9 287.54 True False 274.489470095819 267.5069607484194 461.451164832332 388.6331401368789 525.3379909800316 338.4904946476001 457.8836480799883 346.5187844789663 405.39585143435863 324.4485598767819 0.8460184572866151 0.8244972973528141 1.4222629467289991 1.1978266763904664 1.6191718994824413 1.0432793869578307 1.4112673153916353 1.0680238020183113 1.2494919120254953 1.0 8.341845952148875 -5.248604237716434 24.43050044138274 1.2633407442746278 0.835257759455913 0.4521326823288063 0.18286440405290788 465.6689268504258 886351.8895776303 0.043866656142086326 0.11431980059280138 5.641515195833261e-06 5.248604237716434 -0.4280829848187149 EQDNSESPNGRTS(ph)PLVSQNNEQGSTLR ddPTM_A459_Selumetinib_30min_R2 1 EQDNSESPNGRTSPLVSQNNEQGSTLR 27 1 A0A1W2PNZ9;Q15652-3;Q15652;H7BXU7 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 EQDNS(0.006)ES(0.071)PNGRT(0.218)S(0.681)PLVS(0.024)QNNEQGSTLR 66.372 0.00063703 6820400.0 8893.3 10196.0 11625.0 12787.0 12642.0 7506.5 4407.3 4174.6 3883.7 9000.7 True False 8399.045988700618 10978.00041469272 10877.060156342988 11045.388541194641 11053.798939086038 8540.452237777508 4612.248182899273 4186.747394857767 4660.548519644619 8740.826404372918 0.9608983865071029 1.2559453656693804 1.2443972289509537 1.2636549486520843 1.2646171457604938 0.9770760615386247 0.5276672901994516 0.47898759238179056 0.5331931220271128 1.0 13.093553970924344 -7.075300997040231 3.3537270476683294 0.5931915679811645 1.2047873037337067 0.726442395635134 0.16162552022781881 0.11868474012036104 2.580865730390325 0.06320518809785684 0.04902527359118394 8.408121968568373e-08 7.075300997040231 0.6115957357525422 EQDRVHS(ph)PCPTSGSEK ddPTM_A459_Selumetinib_30min_R1 2 EQDRVHSPCPTSGSEK 16 1 X6RLP6;Q96LT9-2;Q96LT9 X6RLP6 RNPC3 RNA-binding protein 40 1 EQDRVHS(1)PCPTSGSEK;EQDRVHS(0.999)PCPT(0.001)SGSEK 118.76 0.00095519 14227900.0 3587.1000000000004 3250.2 4167.5 4260.4 3654.1000000000004 2780.1 3200.9 2946.1000000000004 2024.69 2107.59 True False 3670.672450718433 2869.6650730230126 3601.576390438879 3516.4011176127906 3323.5873001837517 2752.1347181288343 2959.453535940626 2867.959857718516 3435.751052493227 2378.1197061650787 1.5435187897407008 1.2066949639177722 1.5144638771135406 1.478647651124042 1.397569387095034 1.1572734168907277 1.2444510376279576 1.2059779204064318 1.4447342762377884 1.0 11.215605621757476 -6.672901204392331 6.250480370715289 1.2259919309945142 1.4260343498717027 0.39922416476064937 0.1331146484194587 0.24020023533741053 13.788033174446372 0.042712172846380216 0.042514541538572835 2.1237275238324182e-07 6.672901204392331 0.20004241887718854 EQDRVHS(ph)PCPTSGSEK ddPTM_A459_Selumetinib_30min_R2 4 EQDRVHSPCPTSGSEK 16 1 X6RLP6;Q96LT9-2;Q96LT9 X6RLP6 RNPC3 RNA-binding protein 40 1 EQDRVHS(1)PCPTSGSEK;EQDRVHS(1)PCPTSGSEK;EQDRVHS(0.982)PCPT(0.012)S(0.005)GS(0.001)EK;EQDRVHS(0.997)PCPT(0.002)SGSEK 110.64 0.0015181 17933200.0 62098.7 62726.9 65319.5 72180.4 67536.9 46236.1 50398.3 45643.100000000006 39842.3 62077.2 True False 58647.50285479218 67537.85153122684 61116.9144844943 62349.3050018648 59052.310834453376 52604.70308547325 52741.92081233688 45775.91386437803 47811.87328687506 60284.86994006445 0.9728395020690905 1.1203118062355173 1.0138018800613997 1.0342446631112057 0.9795544204236238 0.8726020830396274 0.8748782383502394 0.7593267416830907 0.7930990534508889 1.0 15.879508345167862 -6.699285251992798 1.6784421376780905 0.8355809114118138 1.0429233473934705 0.5888155612108203 0.06907742942976611 0.22611265192460323 1.3177373527321934 0.02773276294103946 0.026514477962779736 1.9985487576707172e-07 6.699285251992798 0.2073424359816567 EQDVVTGVS(ph)PLLFR ddPTM_A459_Selumetinib_30min_R1 3 EQDVVTGVSPLLFR 14 0 Q6P0Q8;Q6P0Q8-2 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 EQDVVT(0.019)GVS(0.981)PLLFR;EQDVVT(0.011)GVS(0.989)PLLFR;EQDVVT(0.001)GVS(0.999)PLLFR 173.51 0.00010295 47317000.0 6607.5 7745.9 8282.8 9009.7 7909.5 6752.7 8007.099999999999 7236.299999999999 3961.7999999999997 6823.6 True False 6761.441894043108 6839.006427028787 7158.04125416368 7436.325028015198 7194.087121535643 6684.773968961043 7403.11800044681 7044.369817184916 6722.885241576566 7699.475527492559 0.8781691518987222 0.8882431540445461 0.9296790708152033 0.9658222824999276 0.9343606711713904 0.8682116002696136 0.9615093877514717 0.9149155409393207 0.8731614533445977 1.0 12.910544460384452 EQDVVTGVS(ph)PLLFR ddPTM_A459_Selumetinib_30min_R2 3 EQDVVTGVSPLLFR 14 0 Q6P0Q8;Q6P0Q8-2 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 EQDVVT(0.279)GVS(0.721)PLLFR;EQDVVT(0.141)GVS(0.859)PLLFR;EQDVVT(0.218)GVS(0.782)PLLFR 129.05 0.0010842 34076730.0 24308.399999999998 22361.699999999997 25849.0 25752.9 26559.0 18347.2 20927.1 18319.600000000002 18044.0 21584.9 True False 22957.436442235183 24076.77048580172 24185.903482263235 22245.310593769573 23222.420979527462 20874.360260700934 21900.251616261954 18372.90700302697 21653.304191484272 20961.687852694664 1.0952093459059864 1.1486083875973092 1.1538146952777035 1.0612366117697862 1.107850719976358 0.9958339427336476 1.0447751998867132 0.8764994084512664 1.0329943057853854 1.0 14.355467268117241 -6.754759627891505 1.1454795324309808 0.9716379527490681 1.1279984460159067 0.6039563473505147 0.0494897523055783 0.29557836358251066 0.8223217812027244 0.024565740945819346 0.022310294941173696 1.758896853966013e-07 6.754759627891505 0.15636049326683865 EQEAEPEEQEEDSSS(ph)DPR ddPTM_A459_Selumetinib_30min_R2 1 EQEAEPEEQEEDSSSDPR 18 0 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 EQEAEPEEQEEDS(0.054)S(0.365)S(0.581)DPR 105.9 0.0016989999999999998 1287400.0 5944.4 5631.5 7284.9 7125.1 7788.4 6032.3 5383.7 4767.6 5073.9 6427.2 True False 5614.034045318609 6063.417941873485 6816.197465199401 6154.649088516932 6809.951562820577 6863.194569232708 5634.052717599167 4781.472926681331 6088.821776611174 6241.630036128919 0.8994499854721368 0.9714478280154584 1.0920540669255738 0.9860643858882203 1.0910533824340753 1.0995836871948415 0.9026572682115307 0.7660615734999279 0.97551789217989 1.0 12.607707130727237 -7.3578407250961275 7.515892483945884 0.8902365628932677 1.0252592095936977 0.2915360085867297 0.08329591678914125 0.31423683653264545 21.629975363220197 0.03534156926861118 0.0237297038255746 4.386915557807466e-08 7.3578407250961275 0.13502264670042996 EQEPMPTVDSHEPR ddPTM_A459_Selumetinib_30min_R1 2 EQEPMPTVDSHEPR 14 0 A6NGP5;Q9H910;Q9H910-3;Q9H910-2;H3BU16 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 0 ; 150.22 0.00851 24772000.0 5816.5 6354.2 6508.7 6779.700000000001 7115.799999999999 5665.0 5438.2 4721.2 3702.1000000000004 4672.7 False True 5952.013133061179 5610.247310012561 5624.8542897299385 5595.752665730784 6472.177146396527 5608.015243408458 5027.99219568006 4595.978439381097 6282.193309314107 5272.486560952349 1.1288816129264994 1.0640609976252275 1.0668314133576366 1.0613118878618906 1.227537912439455 1.063637655322066 0.9536282620266885 0.8716908779661153 1.1915048500719894 1.0 12.36426779739853 -7.008102099134606 24.75718710522454 0.995673469237049 1.106462563020162 0.24283279473878927 0.08722218138196532 470.476491946877 1437615.0950066808 0.031339186627033326 0.026399663631474737 9.815171691138205e-08 7.008102099134606 0.11078909378311308 EQFDT(ph)LTPEPPVDPNQEVPPGPPR ddPTM_A459_Selumetinib_30min_R1 1 EQFDTLTPEPPVDPNQEVPPGPPR 24 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 1 EQFDT(0.583)LT(0.417)PEPPVDPNQEVPPGPPR 99.494 8.979299999999999e-06 11574000.0 1048.1 1269.7 2264.2 2296.7 2002.8 1506.9 1669.6 1265.1 1056.0 1266.1 True False 1072.5186907524142 1121.0429337324842 1956.7340763603374 1895.6244593984823 1821.6470936230598 1491.7419541557285 1543.660727797328 1231.5454383760537 1791.9548728115658 1428.616267858362 0.7507395196893749 0.7847054236705838 1.3696708629068577 1.326895473646126 1.2751129429275574 1.0441865935014152 1.0805285943659517 0.8620547491190639 1.25432904071426 1.0 10.480402739373034 -5.186935773817094 8.766931394268012 1.1508022403629303 0.764600069206352 0.5084222153219494 0.15100317969256913 0.33829444517928736 37.21950405027304 0.04158890129555113 0.11074618458773514 6.502258426955101e-06 5.186935773817094 -0.3862021711565783 EQFDTLT(ph)PEPPVDPNQEVPPGPPR ddPTM_A459_Selumetinib_30min_R2 1 EQFDTLTPEPPVDPNQEVPPGPPR 24 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 1 EQFDT(0.264)LT(0.736)PEPPVDPNQEVPPGPPR 74.36399999999998 0.00062129 7011900.0 7732.4 8684.6 7581.4 8826.8 9874.7 9238.6 6267.3 6866.3 6438.6 10680.0 True False 7302.664163249713 9350.680894609692 7093.620978004197 7624.574612920696 8634.15190506194 10511.133290339214 6558.741868419349 6886.279796222841 7726.499909515109 10371.64065002752 0.7040992268884996 0.9015623670479637 0.6839439600122835 0.7351367898482354 0.8324769625564525 1.0134494285927003 0.6323726486225635 0.6639527947976648 0.7449640968321253 1.0 13.34035650614405 -2.8680506528984555 17.408623418534745 0.7832991605864211 0.3738552059098076 0.0 0.13163916034474377 0.0 0.0 0.029864311102243253 0.0 0.0013550313622913937 2.8680506528984555 -0.40944395467661354 EQFEGLGS(ph)TPDAK ddPTM_A459_Selumetinib_30min_R1 1 EQFEGLGSTPDAK 13 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 EQFEGLGS(0.5)T(0.5)PDAK 203.2 6.1766e-05 22405000.0 4444.9 5268.3 4833.3 5268.6 4519.0 4727.2 4734.8 4396.8 2377.3 3835.2 True False 4548.457521730186 4651.484986833779 4176.9644074164935 4348.537913870703 4110.257247894252 4679.648659954182 4377.650223990653 4280.182581180804 4034.1044688777797 4327.485278011527 1.051062506172221 1.0748702047511365 0.9652174736769532 1.0048648659687294 0.9498027107749998 1.0813782969365695 1.0115921702227435 0.9890692414203986 0.9322052438573389 1.0 12.07931319625264 -5.252559738417599 24.913127940883626 0.9942534746157643 1.0629663624938162 0.34932354518812214 0.03875075871136869 717.4506449799449 2012901.8527961625 0.010093112266777697 0.02587450871371658 5.590366252341911e-06 5.252559738417599 0.06871288787805185 EQFEGLGS(ph)TPDAK ddPTM_A459_Selumetinib_30min_R2 1 EQFEGLGSTPDAK 13 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 EQFEGLGS(0.899)T(0.101)PDAK 177.39 0.00010385 10396000.0 69871.0 76780.0 87300.0 89739.0 93109.0 76174.0 81039.0 82006.0 56952.0 79837.0 True False 65987.84953577418 82668.77911338818 81683.21304505315 77516.3933915902 81411.81501497877 86666.27706127548 84807.474075732 82244.62388317585 68343.99137183616 77531.89836856256 0.8511058148233188 1.0662550621475368 1.053543312673147 0.9998000180919259 1.0500428433723148 1.117814459402128 1.0938397725357325 1.0607843431384907 0.8814951369686586 1.0 16.242502369292268 -4.757013966463502 24.980683531770538 1.0420796807175237 0.8511055284711296 0.4388487347620589 0.062361588369866064 125.07933433744218 705961.014718933 0.015709853105345385 0.12127510546072195 1.7497904162611713e-05 4.757013966463502 -0.19097415224639402 EQFEGLGST(ph)PDAK ddPTM_A459_Selumetinib_30min_R1 1 EQFEGLGSTPDAK 13 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 EQFEGLGS(0.021)T(0.979)PDAK 184.02 0.00028557 19511000.0 4763.1 5263.5 5112.7 5451.8 4934.3 4389.4 5208.6 4471.9 2600.4 4308.4 True False 4874.070962620767 4647.246973065238 4418.423422050833 4499.74547296062 4487.9934362214235 4345.246621256326 4815.711108532082 4353.290685221621 4412.68887429848 4861.4251073698515 1.0026012650553322 0.955943343860235 0.9088741108759582 0.9256021379695986 0.9231847322748403 0.8938215698662093 0.9905965847815967 0.8954762418579881 0.9076945086758421 1.0 12.247163580787866 -4.882487671967469 3.0427959553656447 0.9273716382568604 1.0068452451166632 0.27899174209999056 0.034957657709971515 0.36172775125195694 5.5793475147235405 0.008485133364087027 0.06212460730115402 1.3107272485924805e-05 4.882487671967469 0.07947360685980276 EQFEGLGST(ph)PDAK ddPTM_A459_Selumetinib_30min_R2 3 EQFEGLGSTPDAK 13 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 EQFEGLGS(0.078)T(0.922)PDAK;EQFEGLGS(0.081)T(0.919)PDAK;EQFEGLGS(0.234)T(0.766)PDAK 152.11 0.0010466 20796800.0 166964.0 174732.0 167929.0 176585.0 181954.0 153570.0 166404.0 170653.0 131824.0 184136.0 True False 157684.8092898484 188133.3825480672 157124.63096727052 152533.81837388405 159095.31183060122 174722.87353033957 174142.1157232705 171149.57197687507 158192.48347030696 178819.51523721637 0.8818098465409028 1.0520852956037563 0.8786772000742419 0.853004316511749 0.8896977022868581 0.9770906340874355 0.9738429023938411 0.9571079070974631 0.8846488777270969 1.0 17.44814466621304 -6.764596337501887 24.999028654536918 0.9568138606010103 0.9138661053419062 0.143079659622105 0.05782104305252446 203.62071604689663 1612397.859465659 0.02092724101714703 0.019220095224333014 1.7195058690317861e-07 6.764596337501887 -0.0429477552591041 EQGDGAEDEEWDD ddPTM_A459_Selumetinib_30min_R1 2 EQGDGAEDEEWDD 13 0 H0YMP5;Q7Z6K5 H0YMP5 ARPIN Arpin 0 ; 128.51 0.02519 9845900.0 6941.1 7993.4 8802.7 9003.8 7499.6 7208.400000000001 7551.1 6903.6 4112.3 6653.1 False True 7102.814124970503 7057.5290119691535 7607.341689769965 7431.455352258489 6821.262504161918 7135.890040703532 6981.514447574515 6720.494101946825 6978.272749491473 7507.090191681914 0.9461474344401295 0.9401151220734116 1.013354241860466 0.9899248793484284 0.9086426737912494 0.9505533913273503 0.9299894192439897 0.89521957647363 0.9295576010560808 1.0 12.874038100589653 -6.257020842900611 24.96731215247515 0.9308825185944456 0.9730067428067677 0.22535565582225536 0.03263526436498568 512.6413700874641 2896715.8226291593 0.009837075295365915 0.01225834637239135 5.533235531689631e-07 6.257020842900611 0.04212422421232209 EQGDGAEDEEWDD ddPTM_A459_Selumetinib_30min_R2 1 EQGDGAEDEEWDD 13 0 H0YMP5;Q7Z6K5 H0YMP5 ARPIN Arpin 0 121.36 0.039559 3581400.0 35087.0 31591.0 28020.0 34977.0 35707.0 25647.0 27341.0 27875.0 24332.0 29502.0 False True 33137.00500438968 34013.92811892484 26217.22370586931 30213.072261309553 31221.167435369818 29179.641449714247 28612.4106751637 27956.11163504533 29199.079892883794 28650.20060459848 1.1566063868701515 1.1872143091893554 0.9150799349607811 1.0545501121712992 1.0897364338300195 1.0184794812581797 0.9986809890109909 0.9757736785465388 1.0191579561993438 1.0 14.806257620110904 -5.241616230421761 24.993931847046902 1.0125570152794294 1.171910386379337 0.6852523558481346 0.04412729139531044 477.46297538349194 602005.040755294 0.01161288674952029 0.030636535328403963 5.733024128374448e-06 5.241616230421761 0.15935337109990755 EQGLTLPLYQS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 EQGLTLPLYQSPVK 14 0 P51587 P51587 BRCA2 Breast cancer type 2 susceptibility protein 1 EQGLTLPLYQS(1)PVK;EQGLTLPLYQS(1)PVK 160.03 2.0600000000000006e-05 3323700.0 34525.0 30000.0 29399.0 33067.0 34900.0 29486.0 28736.0 32859.0 28447.0 31429.0 True False 32606.238714525414 32300.903534796154 27507.500347210993 28563.217556243326 30515.54999004136 33547.428852741985 30072.280939303746 32954.61424989972 34137.19487559039 30521.563107651204 1.068301731452005 1.0582978145932147 0.9012480864820243 0.9358373113296757 0.9998029878879848 1.0991386232224867 0.9852798440642501 1.079715810545712 1.118461553072713 1.0 14.897541228678335 -6.613511197580323 7.527729187564025 1.0568006684070423 0.9867176610772029 0.21953220210018543 0.060119284495938556 0.37499898691469385 26.871663755870348 0.021148891795744314 0.021132053387459198 2.4349430180778277e-07 6.613511197580323 -0.07008300732983941 EQGLTLPLYQS(ph)PVKELDKFK ddPTM_A459_Selumetinib_30min_R1 1 EQGLTLPLYQSPVKELDKFK 20 2 P51587 P51587 BRCA2 Breast cancer type 2 susceptibility protein 1 EQGLT(0.011)LPLY(0.176)QS(0.813)PVKELDKFK 48.773 0.032878 13687000.0 1545.7 1463.9 2689.3 2895.6 1835.0 1925.9 1480.0 1345.8 995.93 1444.9 True False 1581.7118025913633 1292.5059074513529 2324.1078312674936 2389.9378171438357 1669.0245739955628 1906.5271945772897 1368.3624084451646 1310.1050122255103 1690.0204701507778 1630.3669895178496 0.9701569111498785 0.792769919755053 1.4255120756307786 1.4658894791844472 1.0237109710428727 1.1693853021037364 0.8392971749568066 0.8035644861853768 1.036588989483018 1.0 10.670981030936805 -7.2550789958472715 24.027837475840748 0.9034930340776085 1.1477343958606765 0.22838311780584963 0.1982176028144525 464.1896158668926 1753590.0953697166 0.08410574340661407 0.0634456804077772 5.5580315045002235e-08 7.2550789958472715 0.244241361783068 EQIS(ph)DIDDAVR ddPTM_A459_Selumetinib_30min_R1 2 EQISDIDDAVR 11 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 EQIS(1)DIDDAVR;EQIS(1)DIDDAVR 101.61 0.015104 13744100.0 2736.5 3541.1 3381.3999999999996 3302.2 3141.7 2641.78 3656.6000000000004 3244.1 1972.1599999999999 2869.9 True False 2800.255125697913 3126.5063657872724 2922.2244527006656 2725.532759971121 2857.5337897121854 2615.2060917443223 3380.7797180544503 3158.0559296780943 3346.611479132628 3238.279620193281 0.8647354318126413 0.9654837544883362 0.9024002851632216 0.8416607210122404 0.8824234238121875 0.8075911899134363 1.044004877457946 0.9752264473966585 1.0334535221306433 1.0 11.661011850058255 -7.272680133183588 24.99766712745746 1.0111067543091232 0.8811296628241224 0.7127162858270144 0.042186051938669304 445.2339147477531 990126.2308924564 0.018221142568975696 0.012410769297235738 5.3372785229784896e-08 7.272680133183588 -0.1299770914850008 EQIS(ph)DIDDAVR ddPTM_A459_Selumetinib_30min_R2 4 EQISDIDDAVR 11 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 EQIS(1)DIDDAVR;EQIS(1)DIDDAVR;EQIS(1)DIDDAVR;EQIS(1)DIDDAVR 204.17 1.7805e-05 40288800.0 136036.5 124829.0 128397.2 141176.0 138548.8 123071.8 99053.2 114257.3 99321.2 124089.2 True False 128476.13592725676 134402.98291150213 120136.26394030139 121947.58525781597 121143.06110201273 140023.82331543413 103659.37007019218 114589.76982668588 119188.21526619612 120506.42237353894 1.0661351768374117 1.1153180076567821 0.9969283094963175 1.011959220561787 1.0052830273767515 1.1619615001215144 0.8601978884484245 0.9509017658120082 0.9890611049487743 1.0 16.878750511178758 -7.268424281568098 24.999794927360306 0.9459486767585132 1.0546474681218105 0.44907353226898983 0.05922650546595029 550.7794189707056 1971294.9904420078 0.024705368293842025 0.017070629923427838 5.3898380800235084e-08 7.268424281568098 0.1086987913632973 EQISDIDDAVR ddPTM_A459_Selumetinib_30min_R1 2 EQISDIDDAVR 11 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 0 ; 201.46 0.00025931 15774400.0 5749.9 6458.200000000001 7159.2 7001.5 6963.6 5880.9 6161.8 5386.5 3416.2 5316.0 False True 5883.86148264222 5702.070941664272 6187.019962670668 5778.819459432439 6333.743609523435 5821.743485429975 5697.0104651063575 5243.632522182134 5797.04189062393 5998.360382224984 0.980911633798786 0.9506049284003159 1.0314518582452534 0.9633998444903187 1.0559124837334375 0.9705558043297332 0.9497612850985712 0.874177639896505 0.9664377465219289 1.0 12.550352486767043 -7.175523331599923 3.575150208242583 0.9366424005916953 0.995142447387955 0.21281572950569227 0.04162808294653905 0.3102580534653587 7.534433718965628 0.01657015651646018 0.012317777037962054 6.675390378051353e-08 7.175523331599923 0.05850004679625964 EQISDIDDAVR ddPTM_A459_Selumetinib_30min_R2 2 EQISDIDDAVR 11 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 0 ; 182.92 0.00046762 26988000.0 79030.0 73258.0 89634.0 80805.0 89975.0 69926.0 61181.0 64685.0 61911.0 87373.0 False True 74637.82898215619 78876.65303840316 83867.04602612021 69799.21960359991 78671.53611329426 79557.67177497245 64026.03772785158 64873.22264082175 74294.9299378731 84850.31446768303 0.8796411592626864 0.9295976512667486 0.988411728963747 0.8226159212431011 0.9271802539194822 0.9376237704490018 0.7545763162991835 0.7645607803319343 0.8755999362403051 1.0 16.372632386166252 -7.236857326305005 24.605043922240295 0.8290643052526989 0.9146825958151208 0.13284493073388293 0.0755902484930552 938.9459949409918 939825.2356306933 0.02806060778706958 0.02172475075985929 5.7961908064131806e-08 7.236857326305005 0.08561829056242187 EQISS(ph)EPEDFAQPGDVYSQR ddPTM_A459_Selumetinib_30min_R2 2 EQISSEPEDFAQPGDVYSQR 20 0 Q9C0G0-3;Q9C0G0-2;Q9C0G0 Q9C0G0-3 ZNF407 Zinc finger protein 407 1 EQIS(0.131)S(0.869)EPEDFAQPGDVYSQR;EQIS(0.013)S(0.987)EPEDFAQPGDVYSQR 162.92 4.4261e-07 6489400.0 25466.0 25818.0 27592.0 27924.0 28061.0 20123.2 21711.2 23551.2 22245.9 23705.3 True False 24050.701668475154 27798.157582045587 25816.76075989814 24120.703028413183 24535.7263114771 22894.98813977811 22720.81381992665 23619.73009288896 26695.70160237973 23020.866395233836 1.0447348616494527 1.2075200431118798 1.121450440511794 1.0477756403384997 1.065803775159257 0.9945319931363753 0.9869660606965989 1.0260139513158857 1.159630621369955 1.0 14.49065451017798 -5.760838891502757 3.9630466151188983 1.0371480799857937 1.1350118534320357 0.29762939540357336 0.05923691795098734 0.24230421505442734 8.458736718965486 0.01678108502804984 0.028176268981191546 1.7344472994439238e-06 5.760838891502757 0.09786377344624198 EQIVPKPEEEVAQK ddPTM_A459_Selumetinib_30min_R2 1 EQIVPKPEEEVAQK 14 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 139.86 0.0015984000000000007 6637600.0 25944.0 26158.0 25781.0 27529.0 25907.0 18500.0 19338.0 20581.0 17180.0 22402.0 False True 24502.136342060745 28164.234488773272 24122.27852823042 23779.502709826196 22652.331048481417 21048.20707372063 20237.255317520045 20640.887302632047 20616.48004930724 21755.196052613912 1.1262659404587063 1.2945980546743594 1.1088053846948487 1.0930493410547344 1.0412377343646009 0.967502523204872 0.9302262902424414 0.9487796502827663 0.9476577457379496 1.0 14.409072397708488 -6.088130818215824 1.0517912431438965 0.950179771416306 1.2102311591272188 0.8024595619491431 0.04770983967961628 0.20867138994961015 0.4751421297279985 0.019238408006130886 0.03591965731497961 8.163364373985349e-07 6.088130818215824 0.26005138771091274 EQIVVDLSHPGVSEDDQVS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 EQIVVDLSHPGVSEDDQVSR 20 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 1 EQIVVDLSHPGVS(0.052)EDDQVS(0.948)R 75.193 0.004084900000000001 3328000.0 826.35 1260.9 1340.2 1219.2 1240.3 1183.4 1327.5 1250.7 446.56 1047.8 True False 845.6023472028036 1113.273241823493 1158.2082011916466 1006.2896072184573 1128.115083992751 1171.4960704412301 1227.3656062236187 1217.5273731538464 757.7797045480415 1182.295336436294 0.7152209106665688 0.941620259772952 0.9796268034709064 0.851132180096085 0.9541736732153112 0.9908658474221718 1.0381209909219271 1.0297996918635826 0.6409394346696496 1.0 10.207374749272565 -4.761394531012232 24.904378021786805 0.9413298857984425 0.7152206508632262 0.2621683298227102 0.1109473608967177 1.3817342151982626 758456.0057528142 0.0268832082091554 0.15019904472790974 1.7322296539298828e-05 4.761394531012232 -0.22610923493521629 EQIVVDLSHPGVSEDDQVSR ddPTM_A459_Selumetinib_30min_R1 1 EQIVVDLSHPGVSEDDQVSR 20 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 0 159.72 1.4609e-06 33489000.0 4019.8 3890.9 4106.2 4358.5 4037.6 3276.0 4072.3 3052.6 1743.0 2604.7 False True 4113.453518830797 3435.3516191696635 3548.6005937420814 3597.3697941778587 3672.3997928961776 3243.046414370009 3765.1231323724614 2971.635131757759 2957.7436963168157 2939.0386169265266 1.3995915178319107 1.168869166735261 1.2074018263336053 1.2239954158682598 1.2495241715253667 1.1034378370167166 1.2810730388802463 1.011090876670862 1.00636435305156 1.0 11.521128599786882 -7.771357146024029 24.851816827759226 1.0065455858042753 1.2251887426793435 0.6734809500958421 0.07246248762619548 114.52428562884712 286968.3680563637 0.037582930242216164 0.018401655533278313 1.6929450190818146e-08 7.771357146024029 0.2186431568750682 EQIVVDLSHPGVSEDDQVSR ddPTM_A459_Selumetinib_30min_R2 1 EQIVVDLSHPGVSEDDQVSR 20 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 0 138.46 0.00011928 13439000.0 44116.0 37360.0 43612.0 47853.0 49653.0 33522.0 29864.0 36985.0 43332.0 48068.0 False True 41664.20933034041 40225.39186866618 40806.05140115533 41335.33884897065 43415.14623654796 38139.351217581825 31252.735174393376 37092.620226803636 51999.61079723988 46680.15194433733 0.8925465662584375 0.8617236704077573 0.8741627801429088 0.8855013775075115 0.9300558037668204 0.8170357128027392 0.6695080001380453 0.7946122427157879 1.113955474250504 1.0 15.510521636588395 -8.259649394061968 24.992403181334364 1.0569777500651376 0.8404475242916809 0.5868109159802108 0.07261228639548684 116.09269015474615 1620988.9870389246 0.06120685945383037 0.020423076305279127 5.499846973338647e-09 8.259649394061968 -0.2165302257734567 EQLAQGS(ph)QLT(ph)ERLT(ph)SKLSTK ddPTM_A459_Selumetinib_30min_R1 1 EQLAQGSQLTERLTSKLSTK 20 2 A0A087WX83;A0A075B749;Q5VU43-3;Q5VU43;Q5VU43-4 A0A087WX83 PDE4DIP Myomegalin 3 EQLAQGS(1)QLT(1)ERLT(0.889)S(0.015)KLS(0.074)T(0.022)K 77.543 0.006940300000000001 5231700.0 1957.5 1939.8 2292.6 2343.6 1744.1 1784.2 2129.0 2085.5 1197.5 1621.6 True False 2003.1059413680487 1712.6873142114464 1981.2775123503714 1934.334254820518 1586.3464629458645 1766.2525679239836 1968.4078159322673 2030.1857653412849 2032.070038060464 1829.7481557216022 1.0947440690700294 0.9360235226120558 1.082814324012263 1.057158740000298 0.86697530366973 0.965298181829522 1.0757807350574875 1.1095438238278401 1.110573622772185 1.0 10.837429376070405 -7.330705348472804 7.113032238050715 1.083779644627683 0.9979013081252259 0.1987917679207376 0.07111912732789673 0.4135326424368359 36.75474889678923 0.03068581996704752 0.020622098779009407 4.6697609756526905e-08 7.330705348472804 -0.08587833650245713 EQLDTS(ph)NESAEPK ddPTM_A459_Selumetinib_30min_R2 2 EQLDTSNESAEPK 13 0 Q96DX7 Q96DX7 TRIM44 Tripartite motif-containing protein 44 1 EQLDT(0.007)S(0.948)NES(0.045)AEPK;EQLDT(0.061)S(0.935)NES(0.004)AEPK 180.27 0.0001118 7066100.0 54659.0 46090.0 50353.0 55165.0 57760.0 46843.0 53806.0 50306.0 42637.0 53329.0 True False 51621.27159731337 49624.954797291866 47113.34280020119 47651.43183506705 50503.67241904843 53295.19805158355 56308.085614566364 50452.382131393395 51165.59137731738 51789.25320461778 0.9967564388959091 0.9582095073127462 0.909712727736347 0.9201027025201093 0.9751766880960794 1.0290783271389496 1.0872542492955983 0.9741863226344962 0.987957698002782 1.0 15.660365134663076 -6.571519579375382 4.305971481566263 1.0180976989973995 0.9445399202025984 0.45542818779485617 0.0358255400154822 0.2000372136257594 7.946892260918195 0.013017073492208112 0.013262817015134614 2.682133685772679e-07 6.571519579375382 -0.07355777879480119 EQLEEEEEAKHNLEK ddPTM_A459_Selumetinib_30min_R1 2 EQLEEEEEAKHNLEK 15 1 P35579 P35579 MYH9 Myosin-9 0 ; 84.62 0.017172999999999997 39537000.0 9274.8 9233.6 11980.099999999999 12014.8 11270.2 9762.900000000001 10131.400000000001 9908.3 5935.9 7811.299999999999 False True 9490.884794380781 8152.5258194158205 10353.268221978837 9916.640725728608 10250.81239991542 9664.694090003957 9367.180341163068 9645.499697305711 10072.788759017198 8813.956443505273 1.0768018715788317 0.924956445118714 1.1746448134092873 1.1251066180427824 1.1630205419802047 1.0965216531249784 1.0627668063943576 1.0943439259236614 1.1428226158797867 1.0 13.105574051836296 -5.265444879682818 24.99979809544727 1.1114085874371282 1.0008791594201096 0.34218286951382926 0.05886963294350631 319.6264213386873 1994916.4091654152 0.014640792082511631 0.03249525598763037 5.4269412527364755e-06 5.265444879682818 -0.1105294280170186 EQLEEEEEAKHNLEK ddPTM_A459_Selumetinib_30min_R2 2 EQLEEEEEAKHNLEK 15 1 P35579 P35579 MYH9 Myosin-9 0 ; 104.09 0.004164800000000001 18354800.0 132577.0 120231.0 121085.0 130151.0 122399.0 92644.0 100561.0 96241.0 77400.0 120799.0 False True 125208.90108778088 129452.33109640265 113294.52292737983 112424.20927700223 107022.14335905659 105404.87006150138 105237.28575784113 96521.0453764447 92882.1627366928 117311.21899650537 1.067322479118649 1.103494893359338 0.9657603415642182 0.958341497417662 0.9122924838266723 0.8985063062437475 0.8970777616842945 0.8227776183906162 0.7917585677756848 1.0 16.839981465779765 -5.590945019409854 0.7809828244679384 0.8666939040679675 1.1251530673577599 0.650033982004429 0.055356116783876606 0.6219980475964524 0.5964573544041594 0.024856806582506306 0.11620688971409421 2.564808714304159e-06 5.590945019409854 0.25845916328979235 EQLQPHENGEGNS(ph)ET ddPTM_A459_Selumetinib_30min_R1 2 EQLQPHENGEGNSET 15 0 P06756-3;P06756-2;P06756 P06756-3 ITGAV Integrin alpha-V;Integrin alpha-V heavy chain;Integrin alpha-V light chain 1 EQLQPHENGEGNS(0.744)ET(0.256);EQLQPHENGEGNS(0.5)ET(0.5) 178.99 1.9867e-05 22579000.0 7767.9 6255.299999999999 5445.5 3386.6000000000004 7958.4 5774.9 7196.400000000001 9209.4 3278.4 6310.299999999999 True False 7948.876956297763 5522.926567989927 4706.031009990381 2795.1938843553366 7238.5641251696425 5716.809749189671 6653.569754145122 8965.136795652856 5563.205355137721 7120.288472527152 1.1163700722193528 0.7756605071970791 0.6609326332982269 0.3925675055358057 1.016611075955538 0.8028901878410335 0.934452273923618 1.259097413011263 0.7813174110294457 1.0 12.797719976619728 -7.0054969612023825 1.5881711855180842 1.015909936917537 0.7528823741225155 0.17338135889456086 0.21271913388148608 0.6254641429639117 3.18949952382789 0.10719652554985823 0.07990758533246799 9.874225448072015e-08 7.0054969612023825 -0.2630275627950216 EQLQPHENGEGNS(ph)ET ddPTM_A459_Selumetinib_30min_R2 2 EQLQPHENGEGNSET 15 0 P06756-3;P06756-2;P06756 P06756-3 ITGAV Integrin alpha-V;Integrin alpha-V heavy chain;Integrin alpha-V light chain 1 EQLQPHENGEGNS(0.69)ET(0.31);EQLQPHENGEGNS(0.604)ET(0.396) 161.48 0.00012007 30738000.0 87790.0 28389.0 62090.0 75159.0 45814.0 38220.0 108102.0 75312.0 58172.0 42759.0 True False 82910.98325121468 30566.34501497762 58095.19699848057 64922.21454349322 40058.43573764343 43484.45807338396 113128.95720004912 75531.14545142715 69808.02546148429 41524.43656877592 1.9966793074697406 0.7361049911984073 1.3990604520848562 1.5634700891356859 0.9646954672412137 1.0472016399635358 2.724394755186536 1.8189565396348422 1.681131189964804 1.0 15.34167297242229 EQMIDLQNLLT(ph)TQSPSVK ddPTM_A459_Selumetinib_30min_R2 1 EQMIDLQNLLTTQSPSVK 18 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 EQMIDLQNLLT(0.332)T(0.332)QS(0.332)PS(0.003)VK 111.93 0.0029751 5612000.0 47744.0 49643.0 50874.0 54734.0 57124.0 56938.0 47543.0 50001.0 42003.0 55768.0 True False 45090.57961437512 53450.458472596234 47600.82222742307 47279.13477858352 49947.57242496054 64780.69266829759 49753.84370466728 50146.49463188883 50404.7736618773 54157.832937334686 0.832577250026766 0.9869386490121024 0.8789277496110555 0.872987935711711 0.9222594353572865 1.1961463218673183 0.9186823217656584 0.9259324443412033 0.930701450336833 1.0 15.724882391853985 -6.541851926847384 24.997781286861347 0.9931893185963048 0.8984629504100692 0.25474436743171036 0.08271452058293065 378.0402060183515 498076.9132076909 0.028021804104296975 0.028025602908075545 2.871759544511845e-07 6.541851926847384 -0.09472636818623559 EQMIDLQNLLTTQS(ph)PSVK ddPTM_A459_Selumetinib_30min_R2 1 EQMIDLQNLLTTQSPSVK 18 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 EQMIDLQNLLT(0.003)T(0.352)QS(0.595)PS(0.049)VK 107.18 0.0016079999999999998 3990200.0 27748.0 32836.0 32437.0 33251.0 30189.0 28252.0 34179.0 34336.0 27858.0 30743.0 True False 26205.87724404492 35354.415615618906 30350.038734735288 28722.156438825623 26396.387926915733 32143.45655387868 35768.39122440365 34435.912075369204 33430.37841755534 29855.369710093277 0.8777609354201177 1.1841895095898463 1.0165688460550122 0.9620432343571165 0.8841420549547522 1.0766390390071727 1.1980555448392702 1.1534244060534067 1.1197442450780788 1.0 14.86570281380054 -6.993057151281913 24.886763422421584 1.1315565505934042 0.9948848053157867 0.31237228194392674 0.09258184002706098 196.03984080445164 702703.2321003603 0.03286244837579741 0.028920046276788094 1.0161149677219914e-07 6.993057151281913 -0.1366717452776175 EQNSALPTS(ph)SQDEELMEVVEK ddPTM_A459_Selumetinib_30min_R1 1 EQNSALPTSSQDEELMEVVEK 21 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EQNS(0.003)ALPT(0.124)S(0.512)S(0.361)QDEELMEVVEK 83.395 0.00090465 3046300.0 1518.8 1597.3 1374.8 1308.3 1410.8 1124.0 1576.1 1329.3 858.11 1073.6 True False 1554.185084929652 1410.2873734353761 1188.1097112358414 1079.8299648326017 1283.1933890969697 1112.6935805103456 1457.2135080746098 1294.0426458250645 1456.1499961253144 1211.4070177495762 1.2829586275774203 1.1641730258879124 0.9807683906627732 0.8913849342218568 1.0592586721849693 0.918513401529892 1.2029099111392527 1.068214585902763 1.202031996504689 1.0 10.24246795880369 -10.792409331852822 14.826194966635587 1.0000002237775436 1.076348928186017 0.03718087506557399 0.12281375010709439 0.0 0.0 0.12457291071150563 0.030213368762010324 1.6128377061330166e-11 10.792409331852822 0.07634870440847341 EQNSALPTS(ph)SQDEELMEVVEK ddPTM_A459_Selumetinib_30min_R2 1 EQNSALPTSSQDEELMEVVEK 21 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EQNS(0.002)ALPT(0.131)S(0.433)S(0.433)QDEELMEVVEK 63.165 0.008776799999999998 3139300.0 15059.0 12057.0 13297.0 15752.0 16480.0 10105.0 10010.0 12364.0 11311.0 14012.0 True False 14222.081065953316 12981.73313063458 12441.485496678955 13606.550426284348 14409.635066930705 11496.872025943081 10475.48483443871 12399.97719302961 13573.516055745878 13607.437152451836 1.045169704376752 0.954017496843297 0.9143151173354642 0.9999348351818529 1.0589529024085425 0.8448962061802751 0.7698352538450784 0.9112647043014517 0.9975071649182782 1.0 13.732107752371196 -6.770582446635492 24.999040951359106 0.8907256236033946 0.9880798716885763 0.2547064099505163 0.07450110269205339 273.4064808904017 747545.3030395905 0.0274233910939362 0.024521329825617385 1.695967608538577e-07 6.770582446635492 0.09735424808518167 EQNSALPTSS(ph)QDEELMEVVEK ddPTM_A459_Selumetinib_30min_R1 3 EQNSALPTSSQDEELMEVVEK 21 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EQNSALPT(0.004)S(0.122)S(0.874)QDEELMEVVEK;EQNSALPTS(0.064)S(0.935)QDEELMEVVEK;EQNS(0.001)ALPT(0.025)S(0.126)S(0.848)QDEELMEVVEK 187.51 9.0526e-17 21597700.0 9021.5 9628.9 8102.400000000001 8952.1 8850.0 7527.799999999999 9363.0 8610.7 4761.14 8077.5 True False 9231.683397216788 8501.543911645831 7002.138583297418 7388.7837867292865 8049.519062594404 7452.07716669553 8656.741371805458 8382.316264504538 8079.306840092856 9114.325806512848 1.0128761680452634 0.9327671724847558 0.7682563397386871 0.8106780406565522 0.8831721877708648 0.8176224248391997 0.9497950320823058 0.9196858267360558 0.8864404248441068 1.0 13.153920227643594 -7.279997582872483 24.784431423818106 0.9322874769588362 0.8668632128481324 0.18314615340039764 0.06956011703224405 1504.242690863299 2008903.683890712 0.030990103513611107 0.020936366764944384 5.248103811482321e-08 7.279997582872483 -0.06542426411070379 EQNSALPTSS(ph)QDEELMEVVEK ddPTM_A459_Selumetinib_30min_R2 1 EQNSALPTSSQDEELMEVVEK 21 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 EQNS(0.001)ALPT(0.015)S(0.089)S(0.895)QDEELMEVVEK 78.921 0.0086459 0.0 12364.0 11660.0 13921.0 13606.0 14241.0 10694.0 9355.4 11935.0 8658.1 12327.0 True False 11676.858377013534 12554.284507190778 13025.338016038771 11752.839328340839 12451.918263844667 12167.00142953343 9790.44463737341 11969.728874054383 10389.961927526603 11971.087480607603 0.9754216896275546 1.0487171301293987 1.0880663964020802 0.9817687279772775 1.0401660069743857 1.0163655932882618 0.8178408731231231 0.9998865093455026 0.8679213099359334 1.0 13.547266595457945 -7.0365605892172525 24.154174790740537 0.920788451154518 1.0288751990196223 0.4247684935997136 0.05918208379731666 351.2510652814007 232056.72303083612 0.02113888707475151 0.0163814605760807 9.192622179046746e-08 7.0365605892172525 0.1080867478651043 EQPEMEDANS(ph)EK ddPTM_A459_Selumetinib_30min_R2 1 EQPEMEDANSEK 12 0 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 EQPEMEDANS(1)EK 125.73 0.0028357 7928300.0 38761.0 27107.0 37950.0 47322.0 43855.0 37895.0 39192.0 41467.0 40126.0 39223.0 True False 36606.81879257697 29186.019737257328 35508.33831683585 40876.66196499672 38345.542831325634 43114.69227344021 41014.50565747471 41587.66210476861 48152.32121411535 38090.53007640726 0.9610477648682216 0.7662277127336367 0.932209088337923 1.0731450017366693 1.0066949122106423 1.1319005586678577 1.0767638459008613 1.091811062259998 1.2641546630494445 1.0 15.217144744459967 -5.705483882713748 2.6190039889595678 1.0974482555950267 0.8587058406242398 0.5784241120882075 0.08172168701488342 0.1818548979961736 2.5296446473639236 0.023230383762905146 0.043977924816763624 1.970226323762651e-06 5.705483882713748 -0.23874241497078685 EQPGEEYS(ph)EEEESVLK ddPTM_A459_Selumetinib_30min_R1 2 EQPGEEYSEEEESVLK 16 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 EQPGEEYS(0.937)EEEES(0.063)VLK;EQPGEEYS(1)EEEESVLK 173.56 4.3852e-06 10451200.0 1230.8600000000001 1238.02 1421.1599999999999 1300.96 1059.6599999999999 1307.88 1319.21 1281.06 776.4200000000001 1124.49 True False 1259.5366431633597 1093.0720428601162 1228.1742778730936 1073.7717580437375 963.8139400981681 1294.7239146600266 1219.7009275979362 1247.082127330668 1317.5280325268516 1268.829244960154 0.9926762392704102 0.8614808077618378 0.9679586774591272 0.8462697106870813 0.7596088629943547 1.0204083171969178 0.9612805918862939 0.9828604851946261 1.0383808836059945 1.0 10.30928221355365 -6.821417606278963 24.999999375565036 0.9970585145527021 0.8866467647436637 0.4519630367741736 0.06324504918652296 74.1681690600772 30913.850250538446 0.02274413558348448 0.02005845000581314 1.5086287982659124e-07 6.821417606278963 -0.11041174980903845 EQPGEEYS(ph)EEEESVLK ddPTM_A459_Selumetinib_30min_R2 1 EQPGEEYSEEEESVLK 16 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 EQPGEEYS(0.98)EEEES(0.02)VLK 125.45 0.0012040999999999998 2769800.0 11118.0 10537.0 9549.8 10826.0 9382.4 7194.3 10968.0 6590.3 8259.4 8690.9 True False 10500.106068880337 11345.154018204916 8935.376265036066 9351.48012410833 8203.699032279774 8185.249521646942 11478.033732679696 6609.476681917102 9911.510786917826 8439.971135329975 1.2440926515644792 1.3442171586006684 1.058697490994052 1.1079990647080238 0.9720055792535641 0.9698196108021317 1.3599612544446151 0.7831160291828051 1.1743536355744086 1.0 13.043022349591288 -5.2702228475249715 23.44307237957082 1.0525271030479157 1.2941549081819494 0.31054976951544133 0.14357952782987649 274.1752972876717 731778.5132747197 0.035606760605942554 0.0761541243921929 5.367563024083474e-06 5.2702228475249715 0.2416278051340337 EQPPAETPTDAAVLTSPPAPAPPVT(ph)PSKPMAGTTDREEATR ddPTM_A459_Selumetinib_30min_R1 1 EQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATR 41 2 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 EQPPAETPTDAAVLTSPPAPAPPVT(0.855)PS(0.085)KPMAGT(0.028)T(0.028)DREEAT(0.004)R 80.85 5.9291e-09 16890000.0 818.67 971.05 1163.3 938.0 1071.7 900.28 857.93 869.83 468.88 520.79 True False 837.7434181454815 857.3590145711025 1005.3302495495009 774.195908440709 974.7649242240032 891.2240005888382 793.2156493765948 846.7592827939635 795.655114359741 587.638469424182 1.4256102378157334 1.4589906195406432 1.7107972024612492 1.3174697517664762 1.6587833760767239 1.5166195662141302 1.3498361503695544 1.4409527742860166 1.3539874527605236 1.0 9.198785033985505 -9.062717217933203 0.5806560460618435 0.9821684661549304 1.516960709660817 0.6400477503747988 0.11208028724927689 1.1838314142549937 0.6791218921760713 0.1559808776232072 0.048073001717556664 8.655313085390821e-10 9.062717217933203 0.5347922435058867 EQPPAETPTDAAVLTSPPAPAPPVT(ph)PSKPMAGTTDREEATR ddPTM_A459_Selumetinib_30min_R2 2 EQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATR 41 2 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 EQPPAETPTDAAVLT(0.001)S(0.002)PPAPAPPVT(0.816)PS(0.042)KPMAGT(0.042)T(0.042)DREEAT(0.054)R;EQPPAETPTDAAVLT(0.001)S(0.005)PPAPAPPVT(0.447)PS(0.048)KPMAGT(0.156)T(0.156)DREEAT(0.186)R 60.955 4.0702e-05 24424000.0 77501.0 76574.0 69610.0 78368.0 89133.0 75593.0 68663.0 69189.0 55638.1 83889.0 True False 73193.8046810842 82446.97957578281 65131.36838563754 67694.14320765954 77935.31568086978 86005.24958506829 71855.96555315328 69390.32853514436 66767.27465840279 81466.90660020198 0.8984483115368803 1.0120303202426788 0.7994825273686783 0.830940390800253 0.9566499936389699 1.0557078103767727 0.8820264393465398 0.8517609349729786 0.8195631507903266 1.0 16.31392650785444 -11.559932287558746 3.689235646117654 1.1326244769535905 0.9031890604107614 0.12096606789547715 0.08003115121441501 0.09806647211533075 0.0009849496080117153 0.08704520106706953 0.02002013094321223 2.7546581586879406e-12 11.559932287558746 -0.22943541654282906 EQQEAIEHIDEVQNEIDR ddPTM_A459_Selumetinib_30min_R2 2 EQQEAIEHIDEVQNEIDR 18 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 ; 151.03 0.0001824 10192100.0 43620.0 29218.0 42841.0 48114.0 51199.0 50321.0 64098.0 64795.0 62550.0 36386.0 False True 41195.77502469509 31458.926649322497 40084.656701754015 41560.79019872052 44766.92389513263 57252.26098144306 67078.68400777747 64983.54272261028 75061.74779302477 35335.4416378185 1.1658485960623866 0.8902938577015809 1.1344037273571974 1.1761785978143602 1.266912816712043 1.620250330200136 1.8983400489322058 1.8390471354137619 2.1242623358834254 1.0 15.108828320098938 -6.703483641348289 1.8808977633573385 1.7893007231865554 1.074745126456722 0.5040648773448244 0.2839538525226116 0.24360557034619185 1.776086100704662 0.10798439202809852 0.10310410703772484 1.9793215753104925e-07 6.703483641348289 -0.7145555967298334 EQQEAIEHIDEVQNEIDRLNEQASEEILK ddPTM_A459_Selumetinib_30min_R1 1 EQQEAIEHIDEVQNEIDRLNEQASEEILK 29 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 62.717 0.0013434 2863700.0 439.88 567.65 403.17 336.09 463.04 505.47 449.01 311.13 237.24 414.7 False True 450.1283481425172 501.18927410667453 348.42172845428735 277.3981906906589 421.1581137563517 500.3854307300394 415.1408141999753 302.87782170732885 402.5789526759619 467.93078452007154 0.9619549793121365 1.0710756605182843 0.7446009965162744 0.5928188524188883 0.9000436126217006 1.0693577923992639 0.8871842330821647 0.6472705616450783 0.8603386782702551 1.0 8.870151334509467 -5.255943934696262 24.99215580660926 0.8286256862722943 1.0165153290898004 0.20292074197811893 0.14084204233674527 717.7649178751285 3264222.820221935 0.03865869585713627 0.0964282181639428 5.546973170596513e-06 5.255943934696262 0.1878896428175061 EQQSWVISPPQPS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 3 EQQSWVISPPQPSPQK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 EQQSWVIS(0.005)PPQPS(0.995)PQK;EQQSWVIS(0.001)PPQPS(0.999)PQK;EQQSWVISPPQPS(1)PQK 138.46 0.00040463 7185200.0 93290.0 91839.0 93442.0 99333.6 103554.0 81491.0 83630.6 79379.8 67799.0 102188.0 True False 88105.31526945914 98882.75599107154 87430.0434519573 85804.19231998223 90544.62073549419 92715.64554835515 87519.58861089013 79610.78207596659 81360.69446233868 99237.5669236901 0.8878222028277735 0.9964246308770206 0.8810176041416621 0.8646341801785848 0.9124026670778773 0.9342797130410295 0.8819199354029845 0.8022242437401175 0.8198578117589476 1.0 16.598598743657696 -7.52062475957256 24.950761276462504 0.8550390332127893 0.9125175750085635 0.057124747857410285 0.060373611101411345 167.2508176156783 1851468.4564014995 0.027120974128160256 0.0159904775372902 3.015610455716246e-08 7.52062475957256 0.05747854179577416 EQS(ph)AEEDAEAEVDNSK ddPTM_A459_Selumetinib_30min_R2 1 EQSAEEDAEAEVDNSK 16 0 Q8NEZ4;Q8NEZ4-3;C9J4Z5;H0YMU7 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 1 EQS(0.999)AEEDAEAEVDNS(0.001)K 213.64 1.9199e-08 6498000.0 25095.0 17072.0 23083.0 23930.0 20161.0 20089.0 31158.0 35893.0 20054.0 18107.0 True False 23700.32036324447 18381.36750486801 21597.864910870132 20670.692718447477 17628.194938373188 22856.07740021482 32606.9087384057 35997.44268759397 24065.360355576682 17584.203862364084 1.347818789451757 1.0453340764667836 1.2282537827655984 1.1755262211608843 1.0025017382847374 1.2998073486360255 1.8543295444950505 2.0471465736723062 1.368578329956944 1.0 14.101992396922661 -7.080036487226013 5.415819365831733 1.6511815921856252 1.1571006584992936 0.3043006714928902 0.27949497642670523 0.22088378784702448 11.091863040237778 0.10393497960698991 0.08077296534890113 8.316938934525243e-08 7.080036487226013 -0.49408093368633166 EQS(ph)GTIYLQHADEER ddPTM_A459_Selumetinib_30min_R2 2 EQSGTIYLQHADEER 15 0 M0QXN5;P37198 M0QXN5 NUP62 Nuclear pore glycoprotein p62 1 EQS(0.665)GT(0.335)IYLQHADEER;EQS(0.5)GT(0.5)IYLQHADEER 172.5 2.558e-05 8845900.0 24434.6 15687.7 25206.9 26947.6 29011.0 26207.6 25920.0 29115.0 26702.8 24490.7 True False 23076.6227514538 16890.89614609406 23585.115497197614 23277.290392797124 25366.378818369332 29817.4590110941 27125.331359505635 29199.719829752266 32044.106138570514 23783.589856519557 0.9702750043483465 0.7101911968711455 0.9916549873034606 0.978712235336347 1.0665496239801622 1.25369883987133 1.1405061861201764 1.2277255034209245 1.3473199938228242 1.0 14.53767886912076 -6.161844028335843 1.1575048264490844 1.2092832296528173 0.8503993349769773 0.5980210340892161 0.10968201537246183 0.302807131805844 0.8334122553256756 0.04267479298649092 0.07008372064299785 6.888996619890715e-07 6.161844028335843 -0.35888389467584003 EQS(ph)TPPKSPQ ddPTM_A459_Selumetinib_30min_R1 2 EQSTPPKSPQ 10 1 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 EQS(0.5)T(0.5)PPKSPQ;EQS(0.839)T(0.161)PPKSPQ 150.06 0.0034401 97956000.0 12079.400000000001 13202.9 16631.800000000003 16316.8 14325.7 12712.3 12624.4 11338.3 7746.0 10477.3 True False 12360.826517579171 11657.098330138311 14373.292911937939 13467.377184270115 13029.942964407759 12584.425803844897 11672.131344037254 11037.571452011072 13144.39625454392 11822.163512544359 1.0455638263219116 0.986037650195677 1.2157920922584606 1.139163501670404 1.1021623030828358 1.0644773937098493 0.9873092460320053 0.933633800640571 1.111843550513961 1.0 13.5292064593285 -7.062833193509615 3.5561747980503124 1.0032355292409445 1.099741410091484 0.2693232004492644 0.06919894249760293 0.33517931246546245 8.344447908371594 0.028879697480486008 0.022601594120497018 8.653002047723991e-08 7.062833193509615 0.09650588085053946 EQS(ph)TPPKSPQ ddPTM_A459_Selumetinib_30min_R2 2 EQSTPPKSPQ 10 1 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 EQS(0.792)T(0.208)PPKSPQ;EQS(0.935)T(0.065)PPKSPQ 150.06 0.0034401 73591000.0 200343.0 200969.0 196144.0 219381.0 216718.0 171855.0 160974.0 164495.0 136851.0 186374.0 True False 189208.7380965724 216382.67608281554 183524.30858543975 189500.929346666 189491.94735649822 195526.4663056355 168459.6099639299 164973.6532163866 164225.02393642298 180992.8983621939 1.0453931607743934 1.195531305597424 1.0139862405992313 1.047007540414355 1.0469579142121723 1.0802991060696634 0.9307525957555361 0.911492410526791 0.9073561748692709 1.0 17.465573565675435 -7.263616925786744 24.439951233522812 0.9300246513717983 1.0723185856037913 0.6192579854644096 0.05139153678702792 92.40562109864776 1037114.0761610267 0.020901637244345798 0.014870217477227308 5.449831492645806e-08 7.263616925786744 0.142293934231993 EQSDDET(ph)EESVK ddPTM_A459_Selumetinib_30min_R2 1 EQSDDETEESVK 12 0 O94885;A0A1B0GWB9;A0A1B0GVI0 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 EQS(0.059)DDET(0.93)EES(0.011)VK 192.54 4.285499999999999e-19 0.0 18174.0 15620.0 18353.0 22165.0 17164.0 15658.0 23536.0 26465.0 20057.0 15525.0 True False 17163.961836286315 16818.00377378387 17172.187961235526 19146.08876324231 15007.704871893122 17814.747370827987 24630.470635699225 26542.008768483396 24068.96043940368 15076.752911205731 1.1384388891542605 1.1154924321459139 1.1389845056406258 1.269907975278421 0.995420231417251 1.1816037230130139 1.6336721030556078 1.7604592265192702 1.596428659483736 1.0 13.880038127564339 -7.216114865147092 6.335826374173179 1.5609052559059473 1.1362350945238808 0.42113685784766963 0.2001601386684233 0.17121391437711897 18.062943624467433 0.073756520352181 0.056281992392392816 6.079741788818589e-08 7.216114865147092 -0.4246701613820665 EQSEVSVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 EQSEVSVSPR 10 0 Q7L4I2;E9PI52 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 EQSEVSVS(1)PR;EQSEVSVS(1)PR;EQSEVS(0.002)VS(0.998)PR 161.25 0.00042848 339263000.0 7850.0 7821.3 8330.7 9017.0 8550.0 7546.1 8665.4 7194.400000000001 4544.0 6611.599999999999 True False 8032.8897265589685 6905.578559976275 7199.43669725955 7442.350220053177 7776.654009625104 7470.193085310602 8011.761901446439 7003.581141295303 7710.836119370972 7460.263262437683 1.0767568709008504 0.9256481061125232 0.9650378872698245 0.9975988726195899 1.0424101316612302 1.0013310284803105 1.073924822705057 0.93878471776703 1.0335876695122703 1.0 12.865010826766163 -6.002372896919396 23.768874213335092 1.0147347591170541 0.9825511127736465 0.05210777599786198 0.04817612905268163 132.01077097580276 1322395.4876000772 0.013197856252641287 0.01918940259171163 9.945511023173187e-07 6.002372896919396 -0.032183646343407646 EQSEVSVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 EQSEVSVSPR 10 0 Q7L4I2;E9PI52 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 EQSEVS(0.002)VS(0.998)PR;EQSEVSVS(1)PR;EQSEVSVS(1)PR 193.15 0.00017364 818915000.0 332431.0 306915.0 349966.0 378483.0 398339.0 313279.0 281098.0 271313.0 247676.0 315682.0 True False 313955.81584673125 330454.39361273166 327449.5685741708 326932.9624804073 348296.0936241573 356430.3385863851 294169.61398512026 272102.47591171466 297218.1206456474 306567.44041966245 1.0241003265609512 1.077917449943054 1.0681159360104344 1.0664308056748177 1.1361157373639295 1.162649034412999 0.9595592199303008 0.8875778704327881 0.9695032200379248 1.0 18.22584495538831 -7.369226726747433 6.699774752491757 0.9425269572872536 1.0885768090916506 0.6839325857526959 0.04480091643916606 0.14392766651809277 7.804049912699717 0.019716545201540495 0.01320210328824335 4.2733973193981694e-08 7.369226726747433 0.146049851804397 EQSGLQAS(ph)LEAEQEALEKDQER ddPTM_A459_Selumetinib_30min_R1 2 EQSGLQASLEAEQEALEKDQER 22 1 A0A1B0GTU3;Q96L93-5;Q96L93-6;Q96L93-4;Q96L93;Q96L93-2 A0A1B0GTU3 KIF16B Kinesin-like protein KIF16B 1 EQS(0.004)GLQAS(0.996)LEAEQEALEKDQER;EQS(0.004)GLQAS(0.996)LEAEQEALEKDQER 98.722 8.924700000000001e-05 9109000.0 1117.7 1392.57 1414.05 1157.15 1395.88 1427.1 1717.29 1517.85 899.66 1478.25 True False 1143.7402353343905 1229.5272570117709 1222.029776820659 955.0754748957006 1269.6229004626298 1412.7446697031253 1587.7534327018882 1477.5916873283481 1526.6573114333821 1667.9977868743579 0.6856964945245115 0.7371276309159667 0.7326327327511667 0.5725879748829917 0.7611658183562472 0.846970350212785 0.9518918101667038 0.8858475106835666 0.9152633915025559 1.0 10.70390165925551 -6.803715700900648 2.3637942261110707 0.9270405709355618 0.6883116692054541 0.8267713415304863 0.05263310106010554 0.12250434235930184 1.4027966325151442 0.020708322073288318 0.018631723580627785 1.571391136284596e-07 6.803715700900648 -0.23872890173010775 EQSGLQAS(ph)LEAEQEALEKDQER ddPTM_A459_Selumetinib_30min_R2 2 EQSGLQASLEAEQEALEKDQER 22 1 A0A1B0GTU3;Q96L93-5;Q96L93-6;Q96L93-4;Q96L93;Q96L93-2 A0A1B0GTU3 KIF16B Kinesin-like protein KIF16B 1 EQS(0.008)GLQAS(0.992)LEAEQEALEKDQER;EQS(0.001)GLQAS(0.999)LEAEQEALEKDQER 77.509 0.00085612 7799700.0 18365.1 17548.2 15986.2 20792.0 21945.0 13679.900000000001 14730.9 17779.9 14158.2 17430.5 True False 17344.44126332022 18894.090513643678 14957.665296458521 17960.093731799403 19188.072909210823 15564.182051231945 15415.916038724596 17831.636565379107 16990.23561316075 16927.236175122165 1.0246469703548662 1.1161946532897191 0.883644863326341 1.0610174954724871 1.1335620718408475 0.9194756834613385 0.9107166627344193 1.0534287098555482 1.0037217793493762 1.0 14.047058813388508 -6.7843063499601275 24.999689937463614 0.9766359006978967 1.0398920353466976 0.16702570185804677 0.07380878789236399 493.66574809498997 539704.0730225985 0.026979195193029007 0.023809620024167918 1.6432121975897398e-07 6.7843063499601275 0.06325613464880087 EQSSDLTPSGDVS(ph)PVKPLSR ddPTM_A459_Selumetinib_30min_R1 3 EQSSDLTPSGDVSPVKPLSR 20 1 Q8WYQ5-3;Q8WYQ5 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 1 EQSSDLTPSGDVS(0.925)PVKPLS(0.075)R;EQSSDLTPSGDVS(1)PVKPLSR;EQSSDLTPSGDVS(0.923)PVKPLS(0.077)R 147.28 1.2056e-05 298550000.0 8294.8 9180.309999999998 9366.5 9477.100000000002 8427.04 8829.26 8867.48 8488.07 4760.7300000000005 8058.42 True False 8488.052701128829 8105.475037389666 8094.580746501679 7822.1023921998385 7664.815719914754 8740.445660726664 8198.5988443509 8262.93881046291 8078.611100038068 9092.796702657915 0.9334919693791994 0.8914171626668344 0.8902190394442177 0.8602526426125154 0.8429547003590492 0.9612494314506937 0.9016586549168494 0.9087345819628377 0.8884627430058575 1.0 13.150508381996193 -6.764288646914934 24.999926088706015 0.9244193356137729 0.8831608576516256 0.2852631907019181 0.03730732244974302 118.47695628712441 1039529.0012649699 0.012874796130450237 0.011857109812836863 1.7207245426673733e-07 6.764288646914934 -0.04125847796214732 EQSSDLTPSGDVS(ph)PVKPLSR ddPTM_A459_Selumetinib_30min_R2 2 EQSSDLTPSGDVSPVKPLSR 20 1 Q8WYQ5-3;Q8WYQ5 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 1 EQSSDLTPSGDVS(0.98)PVKPLS(0.02)R;EQSSDLTPSGDVS(0.997)PVKPLS(0.002)R 130.57 9.1168e-05 91504000.0 243606.0 219360.0 232005.0 250644.0 246522.0 206375.0 199382.0 219023.0 158542.0 240867.0 True False 230067.35375208367 236184.20664642958 217078.05088794435 216505.8548149832 215551.70242535745 234801.28296427525 208653.65806793762 219660.32066879023 190254.830033601 233912.54386237613 0.9835614198075893 1.0097115902659328 0.9280308242710726 0.925584627656248 0.9215055288021604 1.003799450372452 0.8920156851045161 0.9390702911513318 0.8133588173259259 1.0 17.83560970458717 -5.269369055035693 22.6806678662566 0.926859677970298 0.9966365081552666 0.22569485576317783 0.05088070818014845 211.6421112688336 605351.888278496 0.012851280132341037 0.027656403731196644 5.3781256557935435e-06 5.269369055035693 0.06977683018496861 EQSSDLTPSGDVSPVKPLS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 EQSSDLTPSGDVSPVKPLSR 20 1 Q8WYQ5-3;Q8WYQ5 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 1 EQSSDLTPSGDVS(0.177)PVKPLS(0.823)R 116.92 0.00014567 118420000.0 185780.0 130650.0 138670.0 169440.0 136230.0 123470.0 122640.0 126550.0 112990.0 131810.0 True False 175455.09133626457 140670.4348940372 129748.12317248042 146361.9796996966 119115.56948834774 140476.87175093446 128343.00300654984 126918.23954851978 135591.1572043786 128004.3028164913 1.3706968240575426 1.0989508305490656 1.0136231385790921 1.1434145296625153 0.930559105181905 1.0974386693260147 1.0026460062873364 0.9915154159346619 1.059270307489303 1.0 16.965832781128327 -4.738141036355023 2.635489461893033 1.0313968917891008 1.4634461703225754 0.7663990598560985 0.05630790601895638 0.25150106597661737 2.0705228438837713 0.013715111790358756 0.2549621858348689 1.827506640258895e-05 4.738141036355023 0.43204927853347463 EQSSEAAET(ph)GVSENEENPVR ddPTM_A459_Selumetinib_30min_R1 1 EQSSEAAETGVSENEENPVR 20 0 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 EQSSEAAET(0.874)GVS(0.126)ENEENPVR 274.68 4.1913e-59 10879000.0 1051.2 1840.4 1650.9 1625.1 1404.4 1336.6 1194.6 1366.4 755.81 1175.0 True False 1075.6909147208655 1624.9251124212522 1426.7168477445825 1341.3067919051136 1277.372267966959 1323.1550175357008 1104.4903602220222 1330.158633307281 1282.5543678216936 1325.8226954692182 0.8113384379350745 1.225597599116509 1.0760992798057791 1.011678859087878 0.9634563296677372 0.9979879074761402 0.8330603812986737 1.0032703753321468 0.9673649215725549 1.0 10.372672138943232 -6.108452976188239 2.7839791035176678 0.9556676875622029 1.0554467339484466 0.09148183276422239 0.10505811208820302 0.5295653792859865 7.960016583377416 0.03189475970674271 0.04427422091023353 7.790171591047486e-07 6.108452976188239 0.09977904638624369 EQSSEAAETGVS(ph)ENEENPVR ddPTM_A459_Selumetinib_30min_R2 2 EQSSEAAETGVSENEENPVR 20 0 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 EQSSEAAET(0.031)GVS(0.969)ENEENPVR;EQSSEAAET(0.005)GVS(0.995)ENEENPVR 163.15 3.9931e-07 27758000.0 59017.0 49557.0 67469.0 67258.0 72137.0 55157.0 51806.0 64804.0 52592.0 54184.0 True False 55737.07140376965 53357.862549129815 63128.11799469288 58097.34437347854 63074.50514703759 62754.376084605945 54215.08165164155 64992.5689111203 63111.86954325766 52619.56713306096 1.0592461025539293 1.0140308150806696 1.1997080446340156 1.1041015260837423 1.1986891679959826 1.192605327328458 1.0303216960060875 1.2351406986448843 1.1993992535830718 1.0 15.683311759988733 -5.2534712498507545 24.76356852123162 1.1514555560070363 1.0366384480877633 0.24641259557452833 0.07512072918012556 661.88494969339 2057009.8952127509 0.018290069782758718 0.046583243958306146 5.578645313639691e-06 5.2534712498507545 -0.11481710791927302 EQTFS(ph)GGTSQDTK ddPTM_A459_Selumetinib_30min_R2 1 EQTFSGGTSQDTK 13 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 EQT(0.063)FS(0.864)GGT(0.063)S(0.011)QDTK 158.91 0.00036446 3592700.0 16781.0 11167.0 15289.0 17839.0 14733.0 14094.0 14964.0 17324.0 14002.0 14414.0 True False 15848.379199665493 12023.472992435625 14305.322385404566 15409.29742600854 12882.108825308876 16035.320567406417 15659.855650603482 17374.409971857407 16802.7912485681 13997.830367930404 1.132202547330104 0.8589526145410283 1.0219671198601348 1.1008347023058562 0.9202932516472202 1.1455575718465616 1.1187344923453884 1.2412216404381413 1.2003854030881798 1.0 13.772915609577163 -6.842122302672058 8.4988412856036 1.155727899155657 1.0048709067939054 0.33083947699687055 0.09441700224872661 0.28933938246087887 27.224345542822277 0.0323175468328218 0.028526925799728927 1.4383934519122576e-07 6.842122302672058 -0.15085699236175154 EQTFSGGT(ph)SQDTK ddPTM_A459_Selumetinib_30min_R2 1 EQTFSGGTSQDTK 13 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 EQT(0.002)FS(0.051)GGT(0.74)S(0.206)QDTK 110.25 0.013229 4184800.0 20154.0 13871.0 17330.0 17531.0 17327.0 14256.0 21930.0 18237.0 12149.0 14623.0 True False 19033.92136285433 14934.861097705263 16215.006667477335 15143.247557338178 15150.227354654631 16219.634596916841 22949.788453470625 18290.066650702134 14579.139471422202 14200.795994883178 1.3403418632105286 1.0516918279148988 1.1418378711531323 1.066366108124825 1.0668576155951788 1.1421637634088322 1.6160916938557444 1.287960664831211 1.0266424133319956 1.0 13.793684178693844 -7.0340040908012815 24.989682332426117 1.2741642929689343 1.1235099939034918 0.04766276552128945 0.17678307697407072 1284.1022646695296 943686.1792699611 0.0671289858974989 0.0520284223590906 9.246894638605748e-08 7.0340040908012815 -0.15065429906544248 EQTFSGGTS(ph)QDTK ddPTM_A459_Selumetinib_30min_R1 2 EQTFSGGTSQDTK 13 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 EQTFS(0.013)GGT(0.056)S(0.927)QDT(0.003)K;EQTFS(0.003)GGT(0.037)S(0.959)QDTK 180.11 0.00011134 8869400.0 3654.6 3953.6 3301.5 3725.6000000000004 3436.3 3541.0 4109.4 3729.7 2112.5699999999997 3743.3 True False 3739.7450693862925 3490.7106740212266 2853.174433841383 3074.993898173461 3125.4872717280405 3505.3807549707585 3799.42464950308 3630.776240226994 3584.8769939919757 4223.789017829722 0.8854005381423757 0.8264405867068693 0.6755011724774568 0.7280178733343698 0.7399723941074089 0.829913790715783 0.8995299323580584 0.859601704749109 0.8487348631428485 1.0 12.044322057205813 -7.010547647096679 3.5528923155820618 0.8893538587558099 0.7667682237322461 0.46215520959769774 0.06576493621978391 0.24463642044459474 6.59389550721139 0.027045984150047782 0.021932543980169562 9.760056975123453e-08 7.010547647096679 -0.12258563502356379 EQTLS(ph)PTITSGLHNIAR ddPTM_A459_Selumetinib_30min_R1 3 EQTLSPTITSGLHNIAR 17 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0Y8W8 D6REX3 SEC31A Protein transport protein Sec31A 1 EQT(0.028)LS(0.592)PT(0.38)ITSGLHNIAR;EQT(0.001)LS(0.509)PT(0.326)IT(0.164)SGLHNIAR;EQT(0.002)LS(0.831)PT(0.04)IT(0.126)S(0.001)GLHNIAR 181.64 4.8115e-08 142480000.0 10149.7 10919.099999999999 11336.3 12257.900000000001 14361.9 11061.199999999999 12708.3 10942.8 3736.1000000000004 8145.9 True False 10386.168262121726 9640.68669584813 9796.892725838568 10117.287874280779 13062.868680799396 10949.93437076604 11749.702699488978 10652.56139677613 6339.888826052358 9191.505612785279 1.1299746417686658 1.0488691518001192 1.0658637592747813 1.1007215031460948 1.421189218731379 1.1913101979217426 1.2783218761402133 1.1589571769350322 0.6897552036778007 1.0 13.166085485913678 -8.210895481118953 10.132294936126916 0.8452220540571364 1.1765762088626064 0.527931888963866 0.12462971015392228 0.4509503543017172 89.30765118311987 0.08808514149788078 0.033127115339687735 6.153249412180531e-09 8.210895481118953 0.33135415480547004 EQTLS(ph)PTITSGLHNIAR ddPTM_A459_Selumetinib_30min_R2 2 EQTLSPTITSGLHNIAR 17 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0Y8W8 D6REX3 SEC31A Protein transport protein Sec31A 1 EQT(0.108)LS(0.861)PT(0.031)IT(0.001)SGLHNIAR;EQT(0.05)LS(0.746)PT(0.203)IT(0.001)SGLHNIAR 181.83 4.7599e-08 44300000.0 92928.0 67622.0 110099.0 128640.0 137161.0 93886.0 82383.0 88565.0 83345.0 115967.0 True False 87763.43378025832 72808.38996099959 103015.35020672767 111119.01008362215 119929.60894510227 106817.94428774781 86213.97273881748 88822.70948727506 100016.32885387163 112618.73139154888 0.7792969490583718 0.6465033752499122 0.9147266083877956 0.9866831983507917 1.0649170654225821 0.9484918092032746 0.7655384825733096 0.7887028062717149 0.8880967457015507 1.0 16.781087279103666 -5.273761553311295 24.210111712951825 0.9152072822930668 0.712900169828124 0.44887025892785637 0.09152917978691003 445.60599751388884 875510.2726090114 0.02709041500376575 0.0571048743460182 5.324004902190778e-06 5.273761553311295 -0.20230711246494282 EQTLSPT(ph)ITSGLHNIAR ddPTM_A459_Selumetinib_30min_R2 1 EQTLSPTITSGLHNIAR 17 0 D6REX3;O94979-3;O94979-9;O94979-2;O94979;O94979-8;H7BXG7;O94979-7;O94979-6;O94979-10;O94979-4;H0Y8W8 D6REX3 SEC31A Protein transport protein Sec31A 1 EQT(0.004)LS(0.248)PT(0.61)IT(0.137)SGLHNIAR 222.13 9.9471e-12 15876000.0 27474.0 21191.0 34244.0 39813.0 44070.0 28510.0 26229.0 24045.0 28139.0 35589.0 True False 25947.105067136046 22816.281560195534 32040.77832204812 34390.40071874424 38533.53260920123 32436.993711987874 27448.700471777494 24114.96696913597 33767.58626935133 34561.453098673184 0.7507527242288362 0.6601655750715948 0.9270668750695025 0.9950507758038822 1.1149280239805812 0.9385309587354455 0.7941998385719278 0.6977416979629756 0.9770302820585883 1.0 15.076876254868514 -5.268505239197592 24.08976167408513 0.9240748923723143 0.7054591425424022 0.3973730291859686 0.11065558592037399 340.25617738454554 1160048.343142893 0.032501133460352626 0.07015342238064069 5.388833444080023e-06 5.268505239197592 -0.21861574982991216 EQVANS(ph)AFVER ddPTM_A459_Selumetinib_30min_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 EQVANS(1)AFVER 148.85 0.00064154 7596700.0 874.89 1452.7 1684.6 1320.2 1112.7 1057.5 1284.2 1233.1 995.58 1059.7 True False 895.2732347604049 1282.6172086580923 1455.8405728454318 1089.6518532232667 1012.0564814631402 1046.8625101331756 1187.331760084649 1200.394182326704 1689.4265457137667 1195.7228173521103 0.7487297405120684 1.0726710154268084 1.2175401788094535 0.9112913439556717 0.8463972308434381 0.8755060076978535 0.992982439453616 1.0039067289733068 1.4128914504240602 1.0 10.223667279233588 -8.060418610279445 11.191402770188528 1.2075447050745387 0.9612520469504863 0.30075199577802425 0.15249695901166574 1.1800402865364048 215.46907243383862 0.10324911063000755 0.03905124381075442 8.701244849944303e-09 8.060418610279445 -0.24629265812405243 EQVANS(ph)AFVER ddPTM_A459_Selumetinib_30min_R2 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 EQVANS(1)AFVER 110.25 0.008928799999999999 10309000.0 14695.0 14784.0 27845.0 27603.0 39029.0 22059.0 14516.0 16882.0 31029.0 24291.0 True False 13878.310728745859 15917.885261947558 26053.483015343692 23843.42378216906 34125.828096313024 25097.42701833532 15191.022762908324 16931.123825034447 37235.66702269814 23589.655714402474 0.5883218855234317 0.6747824323789949 1.10444524204891 1.0107575994681282 1.4466437539178572 1.0639166303309924 0.6439696681810225 0.7177350966888968 1.5784743734078408 1.0 14.525866742478296 -5.202785070984127 4.764038986036502 1.0567636750212734 0.6142170709588244 0.3000309591771896 0.26824598556562246 0.28176280850975816 13.364211142420485 0.0720076069898955 0.20085183849690752 6.269240478264177e-06 5.202785070984127 -0.44254660406244906 EQVANSAFVER ddPTM_A459_Selumetinib_30min_R2 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 166.11 0.008503799999999999 16803000.0 34292.0 45804.0 43543.0 40244.0 47139.0 38166.0 38291.0 42478.0 42335.0 53381.0 False True 32386.187921752517 49317.01951692681 40741.49078603379 34762.69777522774 41216.97739199314 43423.020063547156 40071.607372177066 42601.60394738854 50803.18293873232 51839.75182950555 0.6247365540689052 0.9513359492754578 0.7859121494259358 0.6705799420019968 0.7950843886666474 0.8376394278730351 0.7729899538093385 0.8217941337277207 0.9800043624016108 1.0 15.661771191228803 -8.231405267738898 2.9485187943549978 1.0023927930250442 0.783145939968638 0.5042343485087444 0.08326668119211046 0.21834109520370182 3.5351471465902975 0.07249055079207484 0.021378165252614423 5.869413846477947e-09 8.231405267738898 -0.21924685305640623 EQVEPTPEDEDDDIELR ddPTM_A459_Selumetinib_30min_R2 1 EQVEPTPEDEDDDIELR 17 0 A0A087WZG9;B4DSP0;A0A087WXK2;A0A087WUL4;A0A087WX23;Q86TG7-2;Q86TG7 A0A087WZG9 PEG10 Retrotransposon-derived protein PEG10 0 207.4 2.727e-28 0.0 14388.0 13579.0 15430.0 16325.0 16929.0 11098.0 11514.0 15577.0 12337.0 12494.0 False True 13588.372559727492 14620.465636633238 14437.250598913757 14101.506837804218 14802.227672819783 12626.648762386574 12049.423814558171 15622.326491088834 14804.744724581098 12133.265756689503 1.119927052799922 1.2049901427876046 1.1898899182154636 1.162218574997383 1.2199706138191844 1.0406636610118798 0.993089911338577 1.2875615522124113 1.220178064295568 1.0 13.566680294134647 -6.735476239830142 24.998566630801985 1.1190705948220063 1.1804492933254804 0.12944445872408628 0.090031744150707 599.870807111566 577583.5588544852 0.03146797989339754 0.03145843818818454 1.8387545490296177e-07 6.735476239830142 0.061378698503474105 EQWIQDAEECDR ddPTM_A459_Selumetinib_30min_R2 2 EQWIQDAEECDR 12 0 O94906;O94906-2 O94906 PRPF6 Pre-mRNA-processing factor 6 0 ; 163.51 0.006945699999999999 4171300.0 14620.8 16362.599999999999 20202.8 18976.8 22035.8 15852.8 16713.4 17391.2 16594.300000000003 19697.4 False True 13808.234467699738 17617.558805948534 18902.97384314549 16392.127103194078 19267.465801448536 18036.379302609646 17490.606216973818 17441.805512731855 19913.62368348191 19128.684882008627 0.7218601044908735 0.9210020926487542 0.9882003890881474 0.8569395755278293 1.0072551207935072 0.9428969850182256 0.9143653275100216 0.9118141482447988 1.0410346454194326 1.0 14.223450069782139 -4.767450614004028 3.951437294456516 0.9510570784593333 0.6973117824309877 0.6467869648421527 0.0518331746909155 0.1500577143506897 4.339848471546697 0.012406069425187346 0.11219495482239698 1.7082419625326745e-05 4.767450614004028 -0.2537452960283456 EQY(ph)SRLSGGGHY(ph)NS(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 EQYSRLSGGGHYNSQK 16 1 E9PQL1;Q8TAV0;Q8TAV0-3 E9PQL1 FAM76A Protein FAM76A 3 EQY(0.58)S(0.42)RLS(0.001)GGGHY(0.999)NS(1)QK 63.691 0.04136 0.0 1176.4 1327.8 1586.7 1324.2 1040.8 964.47 834.64 866.3 428.56 959.82 True False 1203.8078311240724 1172.3405587225268 1371.2348551192251 1092.9533283125668 946.6598237681642 954.7683074686939 771.6824328274809 843.3229098610193 727.2350192160266 1083.0222464385229 1.1115264114682302 1.082471355115487 1.2661188259322265 1.0091697856684865 0.8740908387442813 0.8815777428473079 0.7125268528556352 0.7786755190248902 0.671486686083791 1.0 10.080847162416177 -6.269439799735525 1.7235379388626575 0.7870959172290278 1.147683167557384 0.7005012796903198 0.09821356140165732 0.1896987653353542 1.1136319708383475 0.03429127530866724 0.04544891098337695 5.377249653647678e-07 6.269439799735525 0.36058725032835615 EQYS(ph)DAPEEIR ddPTM_A459_Selumetinib_30min_R2 1 EQYSDAPEEIR 11 0 Q8NEJ9-2;Q8NEJ9;H0YJ17 Q8NEJ9-2 NGDN Neuroguidin 1 EQY(0.002)S(0.998)DAPEEIR 122.63 0.0034109 0.0 11423.0 6958.6 12782.0 15570.0 13415.0 16286.0 15767.0 17942.0 15681.0 11490.0 True False 10788.155389892076 7492.302244574423 11959.62003598934 13449.339140251868 11729.687768378364 18529.24867041158 16500.196741717784 17994.208249542 18817.638163747783 11158.25384539477 0.9668318662910288 0.6714583077590265 1.0718182434006291 1.2053265077674025 1.0512117694131358 1.6605867662760658 1.478743625153118 1.6126365736847401 1.686432162637543 1.0 13.445823657102608 -6.1643468042622995 1.0163636976978667 1.5223616269806588 0.832697259869723 0.5355598309790929 0.22526980510435662 0.37855653402607137 0.8143898226166617 0.09554268038836679 0.1655405546602198 6.8494105085051e-07 6.1643468042622995 -0.6896643671109358 EQYVPPRS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 EQYVPPRSPK 10 1 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 EQYVPPRS(1)PK;EQYVPPRS(1)PK 131.79 0.012102 108599000.0 13774.8 17348.2 18260.5 18768.0 14826.7 15881.3 15189.8 15462.2 9451.3 13440.2 True False 14095.726038905037 15317.06467904062 15780.824397746648 15490.521118992794 13485.627602866489 15721.548541066668 14044.021156621851 15052.092227696017 16038.165804359793 15165.380588634354 0.9294673454795479 1.0100019969508676 1.0405821539074025 1.0214396551710754 0.8892376636411782 1.0366735242272214 0.9260579432570982 0.9925298042949716 1.0575511580882806 1.0 13.888494083673459 -8.02085893533005 23.702262658318023 1.0275305827469683 0.9813179901303606 0.1327728211851833 0.04988898987149148 855.3391794396229 971922.3540911893 0.032522613779061876 0.01262345586939795 9.53105695258304e-09 8.02085893533005 -0.046212592616607706 EQYVPPRS(ph)PK ddPTM_A459_Selumetinib_30min_R2 5 EQYVPPRSPK 10 1 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 EQYVPPRS(1)PK;EQYVPPRS(1)PK;EQYVPPRS(1)PK;EQYVPPRS(1)PK;EQYVPPRS(1)PK 156.52 0.0024087 356746000.0 289084.0 317378.0 284462.0 298241.0 278644.0 220327.0 242177.0 243650.0 183505.0 279346.0 True False 273017.8685749419 341719.87206888385 266160.0246188081 257620.06130557836 243638.24961103403 250675.0443206294 253438.71036462163 244358.9811615713 220211.12755809823 271280.5551519276 1.0064041207156973 1.2596548686562055 0.9811245943143556 0.9496444047060475 0.8981043609063215 0.9240435392807336 0.9342310222812917 0.9007611364726117 0.8117468184727487 1.0 18.049426116265025 -5.467400514917851 5.191493433478295 0.9160488355164688 1.1337340826836289 0.5811400315312751 0.07234234247587384 0.12839024418221157 7.390303502497095 0.01819886853865971 0.03797324253778147 3.4087840185021175e-06 5.467400514917851 0.2176852471671601 ERDDILR ddPTM_A459_Selumetinib_30min_R1 2 ERDDILR 7 1 P18206;P18206-2 P18206 VCL Vinculin 0 ; 133.81 0.0087473 3153700.0 2696.7 1698.1100000000001 973.34 944.91 1540.5 998.62 2005.9099999999999 2056.13 1208.24 2315.2 False True 2759.527863135233 1499.2944917700793 841.1657741739123 779.8992066574737 1401.1620469973648 988.5747894744139 1854.6025937325944 2001.594753148491 2050.295033641898 2612.378471957728 1.0563277460586447 0.5739193259568172 0.32199230823684555 0.2985398995701468 0.5363549202529325 0.3784194365732817 0.7099287540609486 0.7661963129134528 0.7848384357973207 1.0 11.35114820913523 -7.948150292042605 1.199325929179806 0.9420253062879094 0.5131992697502863 0.3349639143661278 0.20725662331985747 0.5637194060492313 1.4634303237087618 0.19632796060392646 0.06977331693228817 1.1268074454668263e-08 7.948150292042605 -0.4288260365376231 ERDDILR ddPTM_A459_Selumetinib_30min_R2 3 ERDDILR 7 1 P18206;P18206-2 P18206 VCL Vinculin 0 ;; 120.62 0.026176 18273900.0 21625.1 13853.4 23305.4 25449.699999999997 25996.1 20932.7 30425.0 26812.9 34011.2 16135.8 False True 20423.263514134214 14915.911234298173 21805.955937000934 21983.406956818762 22730.23750991732 23815.989416868757 31839.822785993758 26890.921099885436 40814.3903523282 15669.917528156751 1.3033421188998815 0.9518819232772777 1.3915807723824034 1.4029050834069492 1.450565229145215 1.519854164776209 2.031907489543697 1.716085681469991 2.6046333861674884 1.0 13.93570996637766 -6.715531036509327 1.1132472728530236 1.901295485339125 1.210373087562711 0.29182833510800654 0.3901164120262705 0.5396236155876627 1.4242071413991522 0.1928418080305677 0.18225933493684182 1.9251694594590836e-07 6.715531036509327 -0.6909223977764141 ERDEDDEDGDGDGDGATGK ddPTM_A459_Selumetinib_30min_R1 1 ERDEDDEDGDGDGDGATGK 19 1 P50579-3;P50579;G3V1U3;F8VQZ7;F8VY03 P50579-3 METAP2 Methionine aminopeptidase 2 0 202.16 3.9409e-15 3510700.0 2183.4 2733.6 1678.1 1813.8 2288.9 1835.3 2166.5 2247.9 1319.4 2607.5 False True 2234.2689718431657 2413.5488411838373 1450.2232371434877 1497.053879242814 2081.8693991381174 1816.8385483190707 2003.079160740844 2188.2783897917407 2238.9254348367213 2942.1980242008367 0.7593876936444618 0.8203216851249869 0.49290470091230487 0.5088215908408971 0.7075898297850286 0.6175106275562681 0.6808104499645032 0.7437563249625672 0.7609703413640422 1.0 11.522678634897996 -8.743272152082547 0.8513326958077878 0.9995224034850498 0.6470360772154392 0.536707704355156 0.09612836932986585 0.7688943036908178 1.1240576424534885 0.10161258288916496 0.03514911557848436 1.8060420090895123e-09 8.743272152082547 -0.35248632626961063 ERDEDDEDGDGDGDGATGK ddPTM_A459_Selumetinib_30min_R2 1 ERDEDDEDGDGDGDGATGK 19 1 P50579-3;P50579;G3V1U3;F8VQZ7;F8VY03 P50579-3 METAP2 Methionine aminopeptidase 2 0 164.69 6.1038e-07 5613800.0 21675.0 14622.0 17506.0 20249.0 21555.0 21842.0 25068.0 25564.0 24386.0 18345.0 False True 20470.390271899738 15743.46038285966 16379.683019091657 17491.051268526655 18847.068195855074 24850.53723806519 26233.71167129964 25638.387007651967 29263.881401769853 17815.33218396581 1.1490321965662553 0.8837028813321326 0.919414965151968 0.9817976497945397 1.0579128135942282 1.3948960918298914 1.4725356451624605 1.4391192228639487 1.642623393130328 1.0 14.120831763705038 -6.720931818917404 3.350834508139967 1.4284926240521991 0.9756387229808401 0.5819441807033455 0.16537300379086523 0.15211626059565994 3.5148621114588785 0.055943807348228625 0.05342732820831822 1.9013767588487014e-07 6.720931818917404 -0.45285390107135903 ERDEENQEMSSCK ddPTM_A459_Selumetinib_30min_R1 1 ERDEENQEMSSCK 13 1 O60934;A0A0C4DG07 O60934 NBN Nibrin 0 124.38 0.0060882 3246000.0 1838.2 1953.2 1784.7 2173.8 2156.1 1623.0 2020.5 2141.9 1082.3 1576.0 False True 1881.026483485439 1724.518435981954 1542.3475426553723 1794.186637279758 1961.081135690373 1606.6740935660948 1868.0920582861186 2085.089854128266 1836.5840519355654 1778.2949515399876 1.0577696809275012 0.9697595072676423 0.8673181810023771 1.0089364735169541 1.1027873266985853 0.903491342746449 1.050496182688011 1.1725219443054689 1.0327780834923364 1.0 10.796278916947244 -7.51084717006598 24.47320492962885 1.083891820494041 0.984707350236147 0.19984133427080242 0.07614031840031706 611.3297447070225 1243504.6611423031 0.033565746364056966 0.02126437517052335 3.0842731271271126e-08 7.51084717006598 -0.09918447025789412 ERDHS(ph)PTPSVFNSDEER ddPTM_A459_Selumetinib_30min_R1 3 ERDHSPTPSVFNSDEER 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 ERDHS(0.981)PT(0.019)PSVFNSDEER;ERDHS(0.715)PT(0.285)PSVFNSDEER;ERDHS(0.515)PT(0.367)PS(0.118)VFNSDEER 100.39 0.0018865 79245000.0 7000.900000000001 8271.9 6439.59 6703.7 7328.4 6604.3 8143.699999999999 6292.8 3439.32 5914.700000000001 True False 7164.007348619965 7303.422102498017 5565.129048135885 5533.024639034094 6665.547513934103 6537.866738224623 7529.414152469511 6125.894502104838 5836.2748420059415 6673.909359056832 1.0734349184557093 1.0943244370837768 0.8338634447565164 0.829053009466708 0.9987470844039287 0.979615752400414 1.1281864567506772 0.9178869793596597 0.8744911757133503 1.0 12.704316377516271 -5.226461815932456 24.786277457504756 0.9478221677170592 1.0838797702017466 0.2976739935499447 0.08511311873188264 760.8701816110356 539175.6869602284 0.023519885701069134 0.06222162282129172 5.936605417574254e-06 5.226461815932456 0.13605760248468746 ERDHS(ph)PTPSVFNSDEER ddPTM_A459_Selumetinib_30min_R2 2 ERDHSPTPSVFNSDEER 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 ERDHS(0.456)PT(0.132)PS(0.412)VFNSDEER;ERDHS(0.805)PT(0.191)PS(0.004)VFNSDEER 71.434 0.012719 55951000.0 218613.0 210582.0 226234.0 241795.0 242359.0 167470.0 177840.0 219443.0 177319.0 212747.0 True False 206463.3646371775 226732.96227214826 211678.35074495446 208862.1038803592 211911.69570304963 190537.4723587026 186109.91238327482 220081.54279925567 212787.7547068163 206604.44132691057 0.9993171652611773 1.097425402938886 1.0245585689516492 1.0109274637996593 1.025687997518608 0.9222331869294853 0.9008030572236962 1.0652314218696792 1.0299282694030854 1.0 17.656511742247908 -6.005275995662548 1.7021683642366636 0.9851948187620522 1.0475551593942014 0.1648929165290527 0.05115378286043464 0.6501265578582849 3.7942485660359058 0.018486024374450724 0.030667076731253285 9.879250652855827e-07 6.005275995662548 0.062360340632149236 ERDHSPT(ph)PSVFNSDEER ddPTM_A459_Selumetinib_30min_R2 2 ERDHSPTPSVFNSDEER 17 1 Q6UN15;Q6UN15-5;Q6UN15-3 Q6UN15 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 ERDHS(0.413)PT(0.579)PS(0.009)VFNSDEER;ERDHS(0.226)PT(0.732)PS(0.042)VFNSDEER 82.837 0.0079111 55187000.0 134655.0 130969.0 123186.0 150094.0 143373.0 108577.0 112364.0 112228.0 98676.0 130124.0 True False 127171.41416667406 141013.90116829032 115260.34687477553 129650.9382734078 125361.20196911746 123532.49618612781 117589.14864504195 112554.5648996543 118413.95723780207 126366.98201724562 1.0063658412710896 1.1159078021586826 0.9121080921205007 1.0259874549802417 0.9920408002781067 0.9775694110449596 0.9305369707175112 0.8906959959231573 0.9370640601485744 1.0 16.947260030494448 -5.934823424356048 0.6114935729670231 0.9340401499672196 1.0571588938875396 0.2847024630667806 0.052608725071241105 1.387710021830047 0.9395323857079014 0.03341871078224298 0.10161177114061963 1.1619209321464287e-06 5.934823424356048 0.12311874392031996 ERDS(ph)ELSDTDSGCCLGQSESDK ddPTM_A459_Selumetinib_30min_R2 1 ERDSELSDTDSGCCLGQSESDK 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 ERDS(0.423)ELS(0.07)DT(0.205)DS(0.301)GCCLGQS(0.001)ESDK 89.663 0.00024217 16560000.0 111160.0 106490.0 122720.0 124590.0 110480.0 109800.0 119520.0 123150.0 103980.0 118250.0 True False 104982.17220873704 114657.44058068146 114824.32880743309 107620.62707026211 96600.51469626852 124923.95333483933 125077.91682438717 123508.34611142008 124778.90544394446 114835.81524960253 0.9141936422931469 0.99844669828369 0.9998999750892658 0.9371695305714705 0.841205459170569 1.0878483604031515 1.0891890875030827 1.0755211328710235 1.0865852710909922 1.0 16.809213137570616 -6.791281749572838 24.999927554147877 1.0738839360363082 0.9449034129508997 0.6371220668584078 0.048682434187139606 139.53356628301464 116890.84935743258 0.01771986419343476 0.015629501927795136 1.6170306448245043e-07 6.791281749572838 -0.12898052308540842 ERDSELS(ph)DTDSGCCLGQSESDK ddPTM_A459_Selumetinib_30min_R1 1 ERDSELSDTDSGCCLGQSESDK 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 ERDS(0.015)ELS(0.97)DT(0.01)DS(0.005)GCCLGQSESDK 104.72 3.7303e-05 14540000.0 2834.3 3274.3 2754.8 2552.2 2712.7 2439.4 3066.6 2684.0 1854.8 2497.3 True False 2900.33367541224 2890.943433819228 2380.7132910332402 2106.5061807274824 2467.3367639660823 2414.861850797985 2835.2838930661746 2612.8116011393 3147.460130767888 2817.8527807619394 1.0292708317529626 1.0259384214662646 0.8448678750312506 0.7475572162992451 0.8756088255607596 0.8569865208305926 1.0061859556408486 0.9272349566937997 1.116971103762498 1.0 11.460380524410127 -7.749867325085951 1.5741218605462062 1.0422221894072123 0.8951884666836356 0.2800294119743395 0.08973579691526902 0.574835773363567 2.6885441579470966 0.07642558712017537 0.030205257026787155 1.778822748993489e-08 7.749867325085951 -0.14703372272357673 ERDSELS(ph)DTDSGCCLGQSESDK ddPTM_A459_Selumetinib_30min_R2 1 ERDSELSDTDSGCCLGQSESDK 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 ERDS(0.224)ELS(0.681)DT(0.075)DS(0.02)GCCLGQSESDK 68.834 0.002749 17207000.0 44553.0 38090.0 43706.0 39802.0 45631.0 34157.0 47122.0 42395.0 35416.0 37490.0 True False 42076.92261979006 41011.38052134622 40894.0035434948 34380.89893772027 39898.425833684174 38861.81670362572 49313.2663704716 42518.362431129906 42500.189605719715 36407.566289282 1.1557191789602552 1.126452127985812 1.1232281558883974 0.9443338965461594 1.0958828040486148 1.0674104496533248 1.3544785163239244 1.167844125951557 1.1673449762620174 1.0 15.151950684744586 ERDSELSDT(ph)DSGCCLGQSESDK ddPTM_A459_Selumetinib_30min_R2 1 ERDSELSDTDSGCCLGQSESDK 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 ERDSELS(0.004)DT(0.969)DS(0.027)GCCLGQSESDK 125.98 4.2147e-05 33687000.0 89918.0 83641.0 94813.0 99388.0 86256.0 92100.0 105020.0 102840.0 89772.0 76866.0 True False 84920.71753027364 90055.99575179622 88712.83480458907 85851.18294613696 75419.75014157617 104785.93899944166 109903.63809318207 103139.24737392146 107728.9084392555 74646.67885814754 1.1376355764152621 1.2064300398806929 1.1884364604240694 1.15010050359081 1.0103564056064398 1.4037588892409842 1.4723178549180196 1.381699078266012 1.4431842124413161 1.0 16.187790453687334 -6.778670772573195 24.998319204179264 1.372306122731627 1.1457690996616625 0.35000736342665195 0.13365524163762957 236.4848267218631 343076.47834867245 0.04464129481965663 0.0394643875467322 1.6646741186092562e-07 6.778670772573195 -0.2265370230699646 ERDSELSDTDS(ph)GCCLGQSESDK ddPTM_A459_Selumetinib_30min_R1 1 ERDSELSDTDSGCCLGQSESDK 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 ERDS(0.015)ELS(0.041)DT(0.206)DS(0.729)GCCLGQS(0.007)ES(0.001)DK 67.785 0.0030764 10935000.0 3033.1 2544.6 2557.0 2489.1 2722.5 2761.8 2992.3 3007.2 1803.7 2849.2 True False 3103.7653286147806 2246.6770490475546 2209.7734445956125 2054.425411193785 2476.2503556964134 2734.018799513765 2766.58840188545 2927.439287237744 3060.7471629642214 3214.922573558209 0.965424596580439 0.6988277315061369 0.6873488844709195 0.6390279592083581 0.7702363895363586 0.8504151303674509 0.8605458883022019 0.9105784728114666 0.9520438184539699 1.0 11.650568277553198 -7.4153272178923 1.0204484194832069 0.9727116988851942 0.7399493331229159 0.5203279598716316 0.08410146057614666 0.45217546950893794 0.8866833830779007 0.06799766329190626 0.03427658411290335 3.8430212164077987e-08 7.4153272178923 -0.23276236576227827 ERDTSPDKGELVS(ph)DEEEDT ddPTM_A459_Selumetinib_30min_R2 1 ERDTSPDKGELVSDEEEDT 19 2 Q9UPU7 Q9UPU7 TBC1D2B TBC1 domain family member 2B 1 ERDTSPDKGELVS(0.982)DEEEDT(0.018) 64.76100000000001 0.028343 10733000.0 51076.0 43710.0 50207.0 50514.0 48219.0 35567.0 48936.0 41967.0 27734.0 48903.0 True False 48237.400393427975 47062.416450198 46976.73628124842 43633.90605848957 42161.29813667062 40466.03140492011 51211.62096484439 42089.11702198917 33281.57495270585 47491.043324746795 1.0157157437788331 0.990974574476753 0.9891704412560173 0.9187817955507552 0.8877736765724216 0.8520771196415037 1.0783427227457618 0.8862537875653962 0.700796879216241 1.0 15.53536783047942 -5.775076420442103 3.1247659845117917 0.9015321132196216 1.0012336790472303 0.1869208731668286 0.09189513329181909 0.4475560068771317 8.999641709727877 0.02725106271118541 0.046855558720082985 1.6785086340834028e-06 5.775076420442103 0.0997015658276087 ERECS(ph)PSSPLPPLPEDEEGSEVTNSK ddPTM_A459_Selumetinib_30min_R1 1 ERECSPSSPLPPLPEDEEGSEVTNSK 26 1 Q96GY3 Q96GY3 LIN37 Protein lin-37 homolog 1 ERECS(0.333)PS(0.333)S(0.333)PLPPLPEDEEGSEVTNSK 100.39 1.0503e-06 5723700.0 1031.5 1523.9 1516.6 1418.6 1257.6 1114.5 1542.6 1277.4 847.51 1342.2 True False 1055.5319430503919 1345.4810795581109 1310.6540500874876 1170.8681404200322 1143.8503020473138 1103.2891418850359 1426.2404400456155 1243.5192024200228 1438.1625703186835 1514.4844441351347 0.6969579299001427 0.888408649404428 0.865412685592788 0.7731133488721115 0.7552737213491313 0.7284915643455704 0.9417333044051753 0.8210841697553057 0.9496053761978152 1.0 10.564611044383781 -8.190108173093575 0.9660269126327653 0.998550913832536 0.7967228561884045 0.5056532548887314 0.06882363823565664 0.4630430753810078 0.8716514516286238 0.0657743772093894 0.023467769070472013 6.454934309566903e-09 8.190108173093575 -0.20182805764413148 ERECS(ph)PSSPLPPLPEDEEGSEVTNSK ddPTM_A459_Selumetinib_30min_R2 2 ERECSPSSPLPPLPEDEEGSEVTNSK 26 1 Q96GY3 Q96GY3 LIN37 Protein lin-37 homolog 1 ERECS(0.494)PS(0.253)S(0.253)PLPPLPEDEEGSEVTNSK;ERECS(0.364)PS(0.318)S(0.318)PLPPLPEDEEGSEVTNSK 75.035 0.00010946 31606300.0 90599.0 83899.0 93141.0 101897.0 118731.0 89841.0 76696.0 80476.0 78507.0 87328.0 True False 85563.87027653265 90333.78352219528 87148.40946425307 88018.45281787036 103814.95031139256 102215.78225460195 80262.51597024086 80710.1718364809 94210.59366885686 84806.61373460708 1.0089292156422531 1.065173805959107 1.027613362054219 1.0378725071291537 1.224137431501156 1.2052807882941174 0.9464181204241161 0.9516966694255058 1.1108873414481388 1.0 16.371889158843274 -7.286960527884224 24.99367155696123 0.9982252602195768 1.0937190429395278 0.24700976159378696 0.079052336341803 1234.8778966016887 1209349.5847858733 0.03608655234836473 0.02433909047152962 5.164633074071974e-08 7.286960527884224 0.09549378271995101 ERECSPS(ph)SPLPPLPEDEEGSEVTNSK ddPTM_A459_Selumetinib_30min_R1 1 ERECSPSSPLPPLPEDEEGSEVTNSK 26 1 Q96GY3 Q96GY3 LIN37 Protein lin-37 homolog 1 ERECS(0.123)PS(0.736)S(0.141)PLPPLPEDEEGSEVTNSK 107.58 1.5976e-08 7631300.0 764.04 1036.0 1144.7 1253.3 1155.1 1131.1 926.44 1187.9 538.17 741.54 True False 781.8406454369574 914.7046383766672 989.2560273870151 1034.434682354734 1050.6214089494679 1119.7221609566288 856.5578849188768 1156.393033156995 913.235183618371 836.7238822112714 0.9344069914327412 1.0931977176978747 1.1822968704713386 1.2362915704293724 1.2556369326675771 1.3382218253379563 1.0237043583065761 1.3820485559715476 1.0914415173675904 1.0 9.708607803607235 -4.839699971156491 1.7601566795820942 1.2075036976709663 0.8628791862083729 0.2948317059024914 0.11886747392646545 0.8706204662489389 3.0282305378345864 0.03056719939311927 0.48985738554103614 1.4464386861715713e-05 4.839699971156491 -0.34462451146259343 ERECSPSS(ph)PLPPLPEDEEGSEVTNSK ddPTM_A459_Selumetinib_30min_R1 2 ERECSPSSPLPPLPEDEEGSEVTNSK 26 1 Q96GY3 Q96GY3 LIN37 Protein lin-37 homolog 1 ERECS(0.136)PS(0.277)S(0.587)PLPPLPEDEEGSEVTNSK;ERECS(0.084)PS(0.07)S(0.845)PLPPLPEDEEGSEVTNSK 138.96 1.5747e-09 74656000.0 3488.5 3850.2999999999997 4581.9 5085.8 4181.5 3846.1000000000004 3979.0 3906.6 2031.4 3229.75 True False 3569.775262560632 3399.505086044093 3959.7031465751397 4197.660502289725 3803.2840633037836 3807.4117259793934 3678.860826488722 3802.984277574811 3447.1374324142166 3644.319872929111 0.9795449870023172 0.9328229147217395 1.086541051456205 1.1518364602050883 1.043619713943196 1.0447523430261345 1.0094780246421806 1.0435374528521213 0.9458932126184605 1.0 11.831433879047728 -9.964324458160243 11.265495077193219 0.9999882072405536 1.0301960718308496 0.013022833600939698 0.06174502916714086 0.0 0.0 0.06435452944973707 0.015608266024011084 1.0856142662740223e-10 9.964324458160243 0.030207864590296007 ERECSPSS(ph)PLPPLPEDEEGSEVTNSK ddPTM_A459_Selumetinib_30min_R2 2 ERECSPSSPLPPLPEDEEGSEVTNSK 26 1 Q96GY3 Q96GY3 LIN37 Protein lin-37 homolog 1 ERECS(0.019)PS(0.181)S(0.8)PLPPLPEDEEGSEVTNSK;ERECS(0.012)PS(0.164)S(0.824)PLPPLPEDEEGSEVTNSK 121.35 4.2399e-09 41134000.0 97262.0 101652.0 105427.0 109854.0 112115.0 82579.0 87648.0 87358.0 79397.0 107329.0 True False 91856.56741063487 109448.38153730355 98643.94160023851 94891.69569128002 98030.11137918317 93953.50767247453 91723.80567121714 87612.19731710463 95278.61853753492 104230.13289576804 0.8812861008485239 1.0500646837585235 0.9464052175668257 0.9104055905423567 0.9405160355807567 0.9014044697269041 0.880012364207024 0.8405649583572762 0.9141177881142607 1.0 16.669412894996924 -5.969501983077423 1.4368793306154617 0.8993703913865913 0.9692777778403447 0.10323211486405715 0.0551329315510249 0.6628965884480111 2.776078504969243 0.018759166740652734 0.03445084386408956 1.0727487494341654e-06 5.969501983077423 0.0699073864537535 EREDES(ph)EDESDILEESPCGR ddPTM_A459_Selumetinib_30min_R1 1 EREDESEDESDILEESPCGR 20 1 Q9NSY0 Q9NSY0 NRBP2 Nuclear receptor-binding protein 2 1 EREDES(0.998)EDES(0.002)DILEESPCGR 93.104 0.00071651 10132000.0 1543.0 1192.7 1656.8 1983.4 1550.3 1477.6 1326.4 1284.1 885.06 1354.4 True False 1578.9488978446477 1053.0581295288123 1431.815660150961 1637.036423029107 1410.0756387276958 1462.736685553457 1226.348580109234 1250.041496655356 1501.8821777751932 1528.2504329731992 1.033174186492992 0.6890612342115264 0.9368985797474142 1.07118335300862 0.9226731485260599 0.9571315368173751 0.8024526305700974 0.8179559250792491 0.9827461163242031 1.0 10.577665260499149 -2.9410828643383704 0.00597847715807809 1.7772176779079454 3.296561985119604e-07 0.01294390313086824 0.11117462852591518 222198.89844778122 132.2159157130627 18339.73532925001 21045.69342938881 0.0011452943959174681 2.9410828643383704 -1.7772173482517468 EREDES(ph)EDESDILEESPCGR ddPTM_A459_Selumetinib_30min_R2 2 EREDESEDESDILEESPCGR 20 1 Q9NSY0 Q9NSY0 NRBP2 Nuclear receptor-binding protein 2 1 EREDES(1)EDESDILEESPCGR;EREDES(1)EDESDILEESPCGR 140.67 3.6055e-05 23889000.0 61088.0 52205.0 65672.0 65074.0 65035.0 44214.0 49492.0 47631.0 46401.0 49588.0 True False 57692.9735146395 56208.955634467806 61446.7350182672 56210.808941088624 56864.721879723234 50304.07716526941 51793.47606653753 47769.59832426344 55682.49655226458 48156.265594903045 1.198036699937668 1.1672199856048862 1.2759862970929965 1.1672584708694291 1.1808374502723464 1.0446008747529147 1.0755293299158863 0.9919705719315467 1.156287678547859 1.0 15.55543589837865 -6.706463228418503 4.361232690448437 1.0539886255595827 1.2013922865093523 0.6684479362439733 0.050861428714441534 0.1251769939658075 4.878244115071429 0.016723481178595956 0.016274859949420576 1.9657884162406662e-07 6.706463228418503 0.14740366094976953 EREDS(ph)GDAEAHAFK ddPTM_A459_Selumetinib_30min_R1 1 EREDSGDAEAHAFK 14 1 Q9NPI1-2;Q9NPI1 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 1 EREDS(1)GDAEAHAFK 96.805 0.0063461 16621000.0 4582.0 5397.7 5382.4 5225.3 5239.8 4249.9 5257.5 5232.7 2762.3 3875.6 True False 4688.751684980026 4765.734774677348 4651.499643406892 4312.799446029038 4765.861015161826 4207.1498646004575 4860.922542162464 5093.911797794941 4687.421349590329 4373.071011540849 1.0721874107706169 1.0897913073216123 1.0636689025015256 0.9862175653327491 1.0898201750175964 0.9620584375367988 1.1115581085544095 1.1648362865253596 1.0718831999800338 1.0 12.09443106028588 EREDS(ph)GDAEAHAFK ddPTM_A459_Selumetinib_30min_R2 1 EREDSGDAEAHAFK 14 1 Q9NPI1-2;Q9NPI1 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 1 EREDS(1)GDAEAHAFK 82.755 0.016055 8349700.0 54511.0 44326.0 51553.0 51332.0 46725.0 39149.0 44718.0 47558.0 38644.0 42930.0 True False 51481.49684482248 47725.66166944581 48236.13610666237 44340.49304736088 40854.98777320011 44541.41939076161 46797.47560703596 47696.385906349286 46373.87980357559 41690.49935446456 1.2348496094304857 1.144761094456283 1.1570054773521643 1.0635634912972691 0.979959185085295 1.0683829668735247 1.1224973634676434 1.144058877799015 1.1123368758261105 1.0 15.34743103190432 -5.1783672891501915 1.4385347197503864 1.0765789798707914 1.2312798573480428 0.48254222430356875 0.05222021728026292 0.6378904574810634 1.9513174259118096 0.0171927055415437 0.11484140780403695 6.631819705469512e-06 5.1783672891501915 0.15470087747725136 EREES(ph)EDELEEANGNNPIDIEVDQNK ddPTM_A459_Selumetinib_30min_R1 4 EREESEDELEEANGNNPIDIEVDQNK 26 1 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK 190.23 6.4857e-28 180475000.0 5222.86 5678.67 4999.16 5548.769999999999 5174.150000000001 5077.26 5675.1900000000005 5723.38 3507.83 5159.889999999999 True False 5344.54247608354 5013.808676457941 4320.301530420258 4579.781482812957 4706.149046070376 5026.187374183233 5247.105849178315 5571.577370241671 5952.531308233513 5822.212143084816 0.9179573579144458 0.861151835975775 0.742037806978845 0.7866050515271031 0.8083094415685257 0.8632779518611254 0.9012220304288348 0.9569519683097034 1.0223831014648754 1.0 12.507351692346823 -7.6076750644229 1.3372052356221846 1.0113518869097997 0.8200481139428033 0.7359545577709872 0.044695665874856044 0.24806702332358066 0.8327654018708546 0.037451511532993365 0.016278919979563367 2.4678850980899044e-08 7.6076750644229 -0.1913037729669964 EREES(ph)EDELEEANGNNPIDIEVDQNK ddPTM_A459_Selumetinib_30min_R2 6 EREESEDELEEANGNNPIDIEVDQNK 26 1 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK;EREES(1)EDELEEANGNNPIDIEVDQNK 157.64 3.7907e-14 280888900.0 437602.0 381349.0 435725.0 449957.0 416837.0 351479.0 370922.0 384826.0 329083.0 410679.0 True False 413281.8326996015 410597.2420696989 407690.9278815097 388672.08038088115 364470.20948993944 399892.0418413116 388170.60796799895 385945.7799486262 394908.7953472739 398821.63019781327 1.0362573175748166 1.0295260110793014 1.0222387579111427 0.9745511550817894 0.913867709003557 1.002683935780934 0.9732937698877279 0.9677152659879538 0.9901890104390811 1.0 18.605384131246332 -5.731735838108394 4.526024388268887 0.9716181755694817 1.0308329879216234 0.5332814330237934 0.023469724686815324 0.14852183064427713 6.999831688821808 0.006585312915773619 0.011250338604343138 1.854659386674856e-06 5.731735838108394 0.059214812352141655 EREES(ph)EDELEEANGNNPIDIEVDQNKESK ddPTM_A459_Selumetinib_30min_R1 2 EREESEDELEEANGNNPIDIEVDQNKESK 29 2 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 EREES(1)EDELEEANGNNPIDIEVDQNKESK;EREES(1)EDELEEANGNNPIDIEVDQNKESK 124.9 5.0402e-14 33248000.0 4051.1 3616.6000000000004 7689.9 8307.0 4768.4 4304.4 3921.5 3669.8 2241.03 2344.48 True False 4145.482747931598 3193.166790688273 6645.653817597104 6856.338391702528 4337.099061929399 4261.1016440825015 3625.698097782237 3572.4649828096162 3802.8642316447927 2645.4168451690807 1.567043301890913 1.207056194761693 2.512138618052971 2.591779970035047 1.6394766177774887 1.61074866211119 1.3705583316305305 1.350435561538614 1.4375293022683289 1.0 11.369279354099772 -6.870267960049293 2.0592794806602894 1.323569561731283 1.9521102207115846 0.34801925252328936 0.4009628108963024 0.4302978357591809 3.7341108900557156 0.18450182557831643 0.1574432411440172 1.3481308281092071e-07 6.870267960049293 0.6285406589803015 EREES(ph)EDELEEANGNNPIDIEVDQNKESK ddPTM_A459_Selumetinib_30min_R2 2 EREESEDELEEANGNNPIDIEVDQNKESK 29 2 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 EREES(1)EDELEEANGNNPIDIEVDQNKESK;EREES(1)EDELEEANGNNPIDIEVDQNKESK 94.389 8.0782e-08 19217400.0 53534.0 78277.0 60992.0 69753.0 59032.0 33044.0 20960.0 20927.2 14499.4 65722.0 True False 50558.79459358159 84280.59419977483 57067.84112306851 60252.52106936337 51615.87240722411 37595.51105643376 21934.681531452065 20988.094687315544 17399.68514708528 63824.43509373673 0.7921542042530834 1.320506700544938 0.8941378178945878 0.944035320968726 0.8087164787501475 0.5890457314854184 0.3436721609715364 0.32884105682237624 0.27261792637147464 1.0 15.961821243030707 -6.65155223222822 1.6150129167312488 0.42955365834737014 1.0171916319827308 0.4909975322548613 0.2304822138060445 0.2720356543932092 1.4656282530294436 0.09128636946950786 0.09058808519783988 2.2307339028773554e-07 6.65155223222822 0.5876379736353606 ERELEEAR ddPTM_A459_Selumetinib_30min_R2 1 ERELEEAR 8 1 Q9Y490;H0YMT1;A0A1B0GVU7;Q9Y4G6 Q9Y490;H0YMT1 TLN1;TLN2 Talin-1;Talin-2 0 109.48 0.035036000000000005 4707000.0 31100.0 32195.0 30615.0 38418.0 47786.0 26661.0 32133.0 35404.0 32957.0 36401.0 False True 29371.586503164093 34664.25297675876 28645.264231091685 33185.40212525345 41782.695467739744 30333.3107455387 33627.24817033158 35507.01977855226 39549.32089551914 35350.00854884378 0.8308791909507125 0.9806009786069075 0.8103325969925007 0.9387664526134568 1.1819712974045762 0.858084962090648 0.9512656304981699 1.0044416178709414 1.1187923997492981 1.0 15.109422943477279 -6.004867046670451 24.980978559722345 1.0126453492472203 0.8829281757379426 0.33278957729645087 0.09238032991857693 274.00207274517237 1406381.7329518339 0.02623723116537631 0.03776094485734057 9.888557730258116e-07 6.004867046670451 -0.1297171735092777 ERENMDTDDER ddPTM_A459_Selumetinib_30min_R2 1 ERENMDTDDER 11 1 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 0 120.86 0.01299 2897500.0 14438.0 12330.0 13662.0 17227.0 17731.0 16028.0 13392.0 13422.0 17113.0 15155.0 False True 13635.593759893354 13275.671352801222 12783.001794060898 14880.652881767435 15503.473262848811 18235.71151230241 14014.754535744565 13461.055797868277 20536.078177170817 14717.43577258119 0.9264924930263108 0.9020369823888753 0.8685617516249554 1.0110900507199985 1.0534085898123653 1.2390549409616465 0.9522551857745675 0.9146332286325606 1.3953570781283686 1.0 13.845238711240825 -6.004174735667802 2.7074628725340646 1.0882442297216792 0.8995208314125468 0.29574515111472754 0.13304995368978273 0.3645599666021418 5.393774050120598 0.040521053503903275 0.06063244519598483 9.90433370045913e-07 6.004174735667802 -0.18872339830913243 EREQQIEEHR ddPTM_A459_Selumetinib_30min_R1 1 EREQQIEEHR 10 1 Q16643-3;Q16643;Q16643-2;D6R9W4 Q16643-3 DBN1 Drebrin 0 102.53 0.012098 1090300.0 981.21 1223.8 1472.5 1190.5 1152.3 1163.6 1064.2 1006.3 759.2 923.75 False True 1004.070283897698 1080.5169270708152 1272.5425878635276 982.601523452734 1048.0746684550882 1151.895240464268 983.9265372076646 979.6096550769287 1288.3069502258898 1042.3223105869693 0.9633011532989924 1.0366437675716038 1.2208724450567627 0.9427041074266133 1.0055187899267737 1.105123845824229 0.9439753205067444 0.9398337204595335 1.2359967134354033 1.0 10.025585746524381 ERESSANNS(ph)VSPSESLR ddPTM_A459_Selumetinib_30min_R1 2 ERESSANNSVSPSESLR 17 1 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 ERESS(0.001)ANNS(0.455)VS(0.455)PS(0.066)ES(0.022)LR;ERESSANNS(0.474)VS(0.474)PS(0.051)ESLR 144.3 0.00027176 12950600.0 3021.5 3751.8999999999996 3408.0 4213.5 3864.5 3285.5 3696.1000000000004 3215.7 2269.6 3227.8999999999996 True False 3091.895071184449 3312.6258037890116 2945.212318804005 3477.691322190758 3514.9566573328884 3252.450852995321 3417.300201252819 3130.409189934295 3851.3454349745543 3642.232407408586 0.84890109288339 0.9095042362071325 0.808628332671252 0.9548241114753857 0.9650555659718999 0.8929827889015487 0.9382433131674307 0.8594754095226865 1.0574134223671767 1.0 11.83060726692144 -1.5228803668274211 0.09552021455266901 1.063901511208517 0.4668923914124556 0.3698979411715684 0.056519448303165146 162.26891999920093 1.11001366367541 0.840790812886779 12.68379650705576 0.029999887987704848 1.5228803668274211 -0.5970091197960614 ERESSANNSVS(ph)PSESLR ddPTM_A459_Selumetinib_30min_R1 2 ERESSANNSVSPSESLR 17 1 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 ERESSANNSVS(1)PSESLR;ERESSANNS(0.003)VS(0.994)PS(0.003)ESLR 249.54 8.1747e-30 11905700.0 1778.95 1766.1399999999999 2093.12 1959.4 2368.6 1808.88 1834.63 1888.01 1011.69 1618.62 True False 1820.39607376587 1559.3595077437892 1808.8858006851647 1617.227572493312 2154.3605482102944 1790.684309531631 1696.2423820309136 1837.9338416792136 1716.7640390859212 1826.3856436939452 0.9967205338320766 0.8537953159716675 0.9904183198826584 0.8854797879501496 1.1795759321963382 0.9804524667144741 0.9287427263172026 1.0063229789530712 0.9399789387380918 1.0 10.834775709076196 ERESSANNSVS(ph)PSESLR ddPTM_A459_Selumetinib_30min_R2 2 ERESSANNSVSPSESLR 17 1 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 ERESSANNS(0.12)VS(0.875)PS(0.004)ES(0.002)LR;ERESSANNS(0.022)VS(0.972)PS(0.005)ES(0.002)LR 110.64 0.0011605 12702000.0 44934.0 42806.0 45074.0 51768.0 62871.0 38257.0 39122.0 44601.0 34156.0 47033.0 True False 42436.74816505388 46089.082557016154 42173.987912860546 44717.109095218955 54972.58290612866 43526.55448753139 40941.25051877234 44730.78152590699 40988.15439837821 45675.03508359029 0.9291015997555342 1.009065071820265 0.9233487798241984 0.9790273617388969 1.2035586355986996 0.9529615994355135 0.896359476108675 0.9793267031770154 0.8973863801826408 1.0 15.47911821655552 -9.805543698111785 7.385487429686325 1.000000003519456 0.9780604250180339 0.006579991260949103 0.08427152415016412 0.0 0.0 0.08488104672739859 0.020586677721767806 1.5647908642049697e-10 9.805543698111785 -0.02193957850142214 EREVDEDS(ph)EPER ddPTM_A459_Selumetinib_30min_R1 3 EREVDEDSEPER 12 1 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EREVDEDS(1)EPER;EREVDEDS(1)EPER;EREVDEDS(1)EPER 210.37 2.8805e-05 38976800.0 5392.7 7314.1 4645.5 5072.0 5972.099999999999 5367.6 6719.700000000001 6005.0 2666.91 5235.0 True False 5518.3394176324255 6457.76177176716 4014.6666159049314 4186.27041323164 5431.924609459888 5313.606817390865 6212.827618938496 5845.7278930109915 4525.551486600276 5906.9632432181725 0.9342092019902225 1.0932456333093596 0.679649838775313 0.7087009417297336 0.9195798900046179 0.8995496668260897 1.051780307939361 0.9896333619008911 0.7661384200750012 1.0 12.52820091930904 -6.696308457189538 3.0363625204985007 0.950066053668938 0.8562332525593954 0.08613623445555085 0.12926965304937346 0.6941956793017788 12.980597374884454 0.049939605580720615 0.048225180511711256 2.0122945121706765e-07 6.696308457189538 -0.09383280110954262 EREVDEDS(ph)EPER ddPTM_A459_Selumetinib_30min_R2 1 EREVDEDSEPER 12 1 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EREVDEDS(1)EPER 88.311 0.015026 56720000.0 13581.0 9205.5 12974.0 13976.0 18376.0 10781.0 14082.0 15429.0 12789.0 13168.0 True False 12826.222389050545 9911.53224965221 12139.266965023138 12072.444690055245 16067.442596475661 12265.984889826064 14736.84090295364 15473.895835591553 15347.157354516308 12787.805625427192 1.0030041716889224 0.7750768615018813 0.9492846013303092 0.9440591328703395 1.2564659697772742 0.9591938796314246 1.1524135832695954 1.2100509101282675 1.2001400243369447 1.0 13.642481099990759 -6.11002321331292 5.840374439222612 1.1323683948814367 0.903495668677452 0.5133558563327716 0.10131433615226763 0.18092216457893082 8.222610717369212 0.029532979149912413 0.03853263612996454 7.762056268414378e-07 6.11002321331292 -0.2288727262039847 EREVDEDS(ph)EPEREVR ddPTM_A459_Selumetinib_30min_R2 1 EREVDEDSEPEREVR 15 2 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EREVDEDS(1)EPEREVR 73.735 0.047798 15484000.0 30348.0 26418.0 39950.0 37071.0 34839.0 28376.0 31903.0 23388.0 23691.0 35577.0 True False 28661.37965266959 28444.175652741516 37379.6604942712 32021.86584895808 30462.213355388292 32284.53642831874 33386.55271459519 23456.055207908183 28429.861981847363 34549.79956985293 0.8295671757725221 0.8232804822856632 1.0819067247755476 0.9268321740685106 0.8816900165744714 0.9344348398619717 0.9663312994651133 0.6789056810730445 0.8228661912891203 1.0 15.07638972083106 -7.72053111504524 24.999983457831185 0.8131631639897609 0.9223181832021123 0.12556187754452142 0.10033047729981706 232.31189691350363 141970.97182052504 0.04680987206887428 0.02702528537940553 1.9031318827332306e-08 7.72053111504524 0.10915501921235149 ERFS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 ERFSPPR 7 1 C9JUL9;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 C9JUL9;Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 1 ERFS(1)PPR 88.134 0.017424000000000002 3895000.0 7703.3 11030.0 5633.3 5574.3 7344.7 6563.1 8277.0 8569.7 4178.2 8431.1 True False 7882.771901987483 9738.60247229211 4868.328801501939 4600.853147570409 6680.373181812105 6497.081172818012 7652.659226149071 8342.40371769131 7090.100236345907 9513.313810868525 0.8286042128644782 1.0236814075413136 0.5117384854833755 0.48362255666518067 0.7022130578915714 0.6829461638693548 0.804415724981789 0.8769187985957633 0.745281862587755 1.0 13.215732253061164 -7.42843895642738 3.396032982412026 0.8573150171029963 0.7009784221618546 0.19428114678552477 0.15407578006652378 0.5069075321865611 11.010502088134048 0.079180021573333 0.04917943531439811 3.728730915633725e-08 7.42843895642738 -0.15633659494114172 ERGDYVLAVK ddPTM_A459_Selumetinib_30min_R2 1 ERGDYVLAVK 10 1 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 0 102.53 0.042805 4729500.0 60377.0 63707.0 50353.0 66155.0 62109.0 40582.0 34519.0 36788.0 29733.0 55648.0 False True 57021.48804828099 68593.12204970878 47113.34280020119 57144.57487625963 54306.3121584951 46171.80213328274 36124.20189810085 36895.046989418755 35680.4308094326 54041.297649132146 1.0551465366079473 1.2692722979202984 0.8718025815384504 1.0574241804346702 1.0049039257177648 0.8543799675769669 0.668455486258683 0.6827194866593151 0.6602437832098503 1.0 15.72177469687572 -6.8457565683573955 2.2232984685179766 0.7265163093336662 1.063241810543058 0.547870448290682 0.12861357236343138 0.21602117008958455 2.185663779112008 0.05080913782612138 0.04434212766032094 1.4264069021176967e-07 6.8457565683573955 0.33672550120939193 ERHPS(ph)WR ddPTM_A459_Selumetinib_30min_R2 1 ERHPSWR 7 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 ERHPS(1)WR 63.534 0.047409 18673000.0 27719.0 41188.0 28560.0 32775.0 33317.0 28980.0 27820.0 33644.0 23510.0 33005.0 True False 26178.48894794874 44346.98715970617 26722.480693776855 28310.988459971406 29131.420602240938 32971.731945752654 29113.685124284184 33741.898469935986 28212.656924284816 32052.059892711455 0.8167490337774407 1.3835924214590198 0.833721164356537 0.8832814039015708 0.9088782655390376 1.028693071712696 0.908324932055445 1.052721684125169 0.8802135344412074 1.0 14.968129457189196 ERIQQFDDGGS(ph)DEEDIWEEK ddPTM_A459_Selumetinib_30min_R1 1 ERIQQFDDGGSDEEDIWEEK 20 1 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6;Q5H9R7-3 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 ERIQQFDDGGS(1)DEEDIWEEK 187.56 7.178899999999999e-16 7349900.0 1349.6 1920.5 2897.5 3047.2 2129.1 1917.7 1978.7 2283.0 1165.0 1399.3 True False 1381.0430541355395 1695.6469671837733 2504.0354148282295 2515.0637230282828 1936.5232809231359 1898.4096791322854 1829.4450659394906 2222.4474237708732 1976.919911766547 1578.913785336235 0.874679204755592 1.073932587663537 1.585922827505738 1.592907571259625 1.2264908311702065 1.2023517032806277 1.1586731859142672 1.4075799732773855 1.2520759082140482 1.0 10.624716681405738 -8.57457099208124 19.401011092283444 0.9999999950878888 1.2771108591567297 0.12358492896240869 0.20917122949256617 4264.145471610307 1600409.5796641451 0.21764924431392677 0.05619679330866127 2.663354695085923e-09 8.57457099208124 0.2771108640688409 ERIVLEFEKMNLYLVEEEQRLLQALETEEEET(ph)ASR ddPTM_A459_Selumetinib_30min_R1 1 ERIVLEFEKMNLYLVEEEQRLLQALETEEEETASR 35 3 E5RJW6;Q9Y577-2;Q9Y577 E5RJW6 TRIM17 E3 ubiquitin-protein ligase TRIM17 1 ERIVLEFEKMNLYLVEEEQRLLQALET(0.014)EEEET(0.493)AS(0.493)R 48.947 0.0057545 13733000.0 5556.2 5165.4 3824.5 3319.2 3545.5 3582.6 5193.4 5156.6 2663.6 4803.5 True False 5685.6486495168065 4560.63256667069 3305.153906474745 2739.564029100641 3224.8101510088673 3546.562296740538 4801.657656769673 5019.83021700258 4519.934658353108 5420.076015052245 1.048997953852867 0.8414333219691439 0.6097984414417639 0.5054475290554084 0.5949750782190428 0.6543381101835621 0.8859022721147923 0.9261549474697162 0.8339245881055304 1.0 12.404097369778112 -7.309592607832251 6.409202142714126 0.9070825670130779 0.6962718331203996 0.31043167852529074 0.14700038280321043 0.3160282370869597 32.4175192229499 0.06867429623747445 0.04639566822054943 4.9023847446092936e-08 7.309592607832251 -0.21081073389267824 ERLDDWDRER ddPTM_A459_Selumetinib_30min_R1 1 ERLDDWDRER 10 2 H0YIQ2;P49750-3;P49750-1;P49750 H0YIQ2 YLPM1 YLP motif-containing protein 1 0 86.882 0.021841 5400300.0 927.25 857.15 1753.4 1636.0 1232.8 977.97 776.6 758.58 510.2 443.51 False True 948.8531208855808 756.7944795217754 1515.2979107367798 1350.303311523455 1121.2934576685175 968.1325097257136 718.020436755753 738.4599941848925 865.7721364663446 500.43882865323616 1.8960421665103442 1.5122617115031518 3.0279383292753237 2.698238494317767 2.2406204184557463 1.9345671324727514 1.4347816269334357 1.4756248953987259 1.7300259030584835 1.0 8.967049921189368 -7.04645475144637 2.460717214624744 1.4431782257987391 2.2986103723357423 0.48488798594926374 0.4192432105723608 0.29470653884361836 3.542822455859734 0.19364717167254716 0.14929776498162328 8.985562070475486e-08 7.04645475144637 0.8554321465370032 ERLEQEQLER ddPTM_A459_Selumetinib_30min_R2 2 ERLEQEQLER 10 1 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7;A0A075B6E5;A0A0U1RQP7 A0A0U1RRM6 ENAH Protein enabled homolog 0 ; 116.74 0.017591 8122600.0 33872.0 33471.0 40760.0 43924.0 50350.0 34746.0 34514.0 36210.0 30251.0 43314.0 False True 31989.52984035929 36038.11807377209 38137.54597613249 37941.47542687368 44024.58286528891 39531.94610721605 36118.96938819356 36315.3651051118 36302.04528356186 42063.412276712734 0.760507246295599 0.856756884978721 0.9066679071409123 0.9020065984489553 1.0466241439395045 0.9398178599291108 0.8586790142127829 0.863348053320363 0.8630313928111701 1.0 15.360278268967905 -4.78355707796355 1.6130179992644311 0.9210695798531964 0.7013626566049076 0.4340748370840929 0.057723749674712194 1.098109826908975 2.7714982773955055 0.017588352913792033 0.38319777741145217 1.646049616965803e-05 4.78355707796355 -0.21970692324828878 ERLNS(ph)SENGEDR ddPTM_A459_Selumetinib_30min_R1 1 ERLNSSENGEDR 12 1 Q7L4I2;H0YGP9;E1B6W4;Q7L4I2-2 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 ERLNS(0.5)S(0.5)ENGEDR 161.49 0.002291 3429500.0 734.9 860.75 852.86 876.56 895.2 807.16 947.14 870.25 408.32 726.66 True False 752.0217401335274 759.9729898481817 737.0462964246434 723.4852510690707 814.2293180603966 799.0407032426426 875.6964672532115 847.1681430296115 692.889217487138 819.9338892677973 0.9171736282361549 0.9268710560638482 0.8989094194933537 0.8823702258668008 0.9930426449228792 0.9745184504523744 1.0680086269335816 1.0332151824900595 0.8450549813301284 1.0 9.679363780638967 -6.27139891732372 24.309001026420365 0.9908631021808804 0.9072681051143228 0.32837995566474276 0.05525639164252666 553.5348701578707 1351051.7843293038 0.017349244305185484 0.019914845785527865 5.35304732232694e-07 6.27139891732372 -0.0835949970665576 ERLNSS(ph)ENGEDR ddPTM_A459_Selumetinib_30min_R2 2 ERLNSSENGEDR 12 1 Q7L4I2;H0YGP9;E1B6W4;Q7L4I2-2 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 ERLNS(0.408)S(0.592)ENGEDR;ERLNS(0.227)S(0.773)ENGEDR 176.43 0.00049153 16683300.0 35525.0 29329.0 32217.0 33555.0 37760.0 24044.0 27081.0 30736.0 28049.0 34777.0 True False 33550.662717842606 31578.439992401225 30144.19329521739 28984.751114396375 33016.25122131698 27355.842750299398 28340.320159983487 30825.436671381278 33659.58375454125 33772.897648502556 0.9934197256932793 0.9350231159037481 0.8925557294179625 0.8582251785458367 0.9775960465382477 0.809993949438695 0.8391438737339156 0.9127270331436318 0.9966448276028714 1.0 15.04357834461541 -8.236852736675198 4.528055763939174 1.000558022667607 0.8983155523218337 0.33244480221616746 0.05447010120598084 0.22673629076097893 11.639783935996054 0.04578034902649934 0.014605333897209452 5.79625206095766e-09 8.236852736675198 -0.10224247034577327 ERLPS(ph)VDLK ddPTM_A459_Selumetinib_30min_R2 1 ERLPSVDLK 9 1 H7BZK4;Q8WUM9 H7BZK4 SLC20A1 Sodium-dependent phosphate transporter 1 1 ERLPS(1)VDLK 74.78 0.033407 2960700.0 22224.0 11948.0 14948.0 15607.0 13622.0 15987.0 23502.0 19341.0 13502.0 10160.0 True False 20988.879049720857 12864.373181124829 13986.261954151834 13481.299676423312 11910.682577774889 18189.06413446335 24594.889568329523 19397.27910792509 16202.77727740082 9866.65440114978 2.1272538994854204 1.3038232270125645 1.4175283115745887 1.3663496387237715 1.207165275433881 1.843488521534082 2.4927283928647013 1.9659428940436674 1.6421754141416647 1.0 13.268345261228662 -6.878148258279114 7.774782469596619 1.8990111910256637 1.4652032935281578 0.08824623402989862 0.421268746595705 0.39463899570227745 25.251380798327418 0.14601383356894357 0.12882889299076597 1.3238895122121813e-07 6.878148258279114 -0.4338078974975059 ERLS(ph)WPK ddPTM_A459_Selumetinib_30min_R1 1 ERLSWPK 7 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 ERLS(1)WPK 64.84100000000001 0.045355 4688900.0 2361.8 3056.8 3069.3 3081.3 2646.6 2412.7 2179.4 2345.7 1520.4 2016.3 True False 2416.825344737193 2698.908434932234 2652.50591845808 2543.2087981645614 2407.2154972951826 2388.4304285563258 2015.0061033549948 2283.4844160925695 2580.00775437756 2275.1117454251776 1.0622886324581529 1.1862751095014263 1.1658794007774658 1.1178390702252214 1.0580647311656848 1.049807963656735 0.8856734652294744 1.0036801140358174 1.1340136411169566 1.0 11.15172169178069 -6.442692735388043 1.8983109595714924 1.006024173558213 1.1423169282737031 0.43210477331388053 0.06432053388638473 0.3202917961067397 2.298641258055987 0.024410201628881786 0.028062218139665633 3.60833843729679e-07 6.442692735388043 0.13629275471549018 ERLS(ph)WPK ddPTM_A459_Selumetinib_30min_R2 1 ERLSWPK 7 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 ERLS(1)WPK 74.173 0.031116 65836000.0 63499.0 60194.0 63886.0 66466.0 54754.0 42433.0 57756.0 51408.0 45921.0 48648.0 True False 59969.9797866372 64810.68624578401 59775.644313817524 57413.21613975465 47875.31301302939 48277.76058157772 60441.76844134287 51557.588768947484 55106.48313994396 47243.40583731639 1.269383075241125 1.3718461888408489 1.265269581106327 1.215264122520256 1.0133755635207373 1.0218941612258683 1.2793694139976974 1.091318203147484 1.1664375623066683 1.0 15.527825353757189 -5.907241919858803 2.7785253085732657 1.1058659773420436 1.3134333576815695 0.5538534008110301 0.08323113952426647 0.2085207109913999 3.2548110024485477 0.025351419512969903 0.04052857636387867 1.2381067181263179e-06 5.907241919858803 0.20756738033952593 ERPAGQLS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 ERPAGQLSR 9 1 A0A087WWA7;O14640-2;O14640 A0A087WWA7 DVL1 Segment polarity protein dishevelled homolog DVL-1 1 ERPAGQLS(1)R 72.531 0.036925 3328700.0 797.02 1247.2 1260.4 1436.9 1113.0 1328.3 1294.7 1191.4 727.84 1101.1 True False 815.5890152690482 1101.17724419245 1089.244602881623 1185.9723889535774 1012.3293465161105 1314.9385079999033 1197.0397366310501 1159.8002017873935 1235.0913206696678 1242.436910622259 0.656443001890994 0.8863043545936986 0.8767001314667064 0.954553409363537 0.8147933612251571 1.0583543492291556 0.9634611837405312 0.9334882052131903 0.9940877561751509 1.0 10.278956880076796 -4.002785445414936 0.7709884250080792 0.9629850375027391 3.25542194274822e-33 0.6751522501870615 0.0617696141815544 4.690482690932604 0.8903607315743198 0.02269693718717008 5.154987699996961 9.936067989430393e-05 4.002785445414936 -0.9629850375027391 ERPDLEAPAPGS(ph)PFR ddPTM_A459_Selumetinib_30min_R1 4 ERPDLEAPAPGSPFR 15 1 Q9NQT8;H0YBA8;Q9NQT8-2 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 ERPDLEAPAPGS(1)PFR;ERPDLEAPAPGS(1)PFR;ERPDLEAPAPGS(1)PFR;ERPDLEAPAPGS(1)PFR 157.57 8.45e-05 189824200.0 8048.0 9466.099999999999 9533.3 10496.0 10041.599999999999 7785.4 9607.2 8623.4 4936.889999999999 7882.599999999999 True False 8235.502741318034 8357.804611329497 8238.730222668495 8663.070634321626 9133.339052988467 7707.08594457762 8882.5211691989 8394.679419249125 8377.541753820728 8894.408493026083 0.9259191038701805 0.9396695258467916 0.9262819701982777 0.9739906415490311 1.0268630072645892 0.8665091052002595 0.9986635059727127 0.9438153673548066 0.9418885764454579 1.0 13.11868294945154 -5.369807502890397 0.006230624242919632 1.8866991812010947 3.357163567543816e-08 0.1110520631516273 0.04161915001240297 34462.44668693426 41.027703522994315 5984.9824406484595 6443.189041995376 4.26768638233073e-06 5.369807502890397 -1.886699147629459 ERPDLEAPAPGS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 4 ERPDLEAPAPGSPFR 15 1 Q9NQT8;H0YBA8;Q9NQT8-2 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 ERPDLEAPAPGS(1)PFR;ERPDLEAPAPGS(1)PFR;ERPDLEAPAPGS(1)PFR;ERPDLEAPAPGS(1)PFR 143.69 0.00020697 208593000.0 142877.0 113042.0 128913.0 149737.0 152393.0 127838.0 116539.0 127877.0 83374.0 110300.0 True False 134936.46832194773 121711.95791268125 120618.87792986176 129342.56228926712 133248.02892929423 145446.5241021784 121958.29441764762 128249.10089882302 100051.12966419906 107115.35240618313 1.2597304241717517 1.136269966709791 1.1260652672127993 1.2075072282710517 1.2439676100211627 1.3578494663458032 1.1385696977887896 1.1972989680554882 0.9340503244091807 1.0 16.70880574493524 -8.254837447343428 23.676526308413866 0.9670251467271521 1.2070668547100163 0.67243305307251 0.06738406227207099 138.36770801097435 496237.89848010486 0.05087745843933349 0.018178347158328667 5.561123663550732e-09 8.254837447343428 0.24004170798286417 ERPES(ph)PMVPSEQVVEEAVPLPPQALTTSQDGHR ddPTM_A459_Selumetinib_30min_R1 7 ERPESPMVPSEQVVEEAVPLPPQALTTSQDGHR 33 1 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 ERPES(0.98)PMVPS(0.02)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.767)PMVPS(0.233)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.901)PMVPS(0.099)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.952)PMVPS(0.048)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.957)PMVPS(0.043)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.971)PMVPS(0.029)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.92)PMVPS(0.08)EQVVEEAVPLPPQALTTSQDGHR 132.61 1.8251e-25 114692300.0 7650.42 9957.369999999999 9413.199999999999 9734.54 12048.52 8718.03 10947.69 8150.46 3309.3149999999996 6155.4400000000005 True False 7828.659900874046 8791.556491344269 8134.939143006414 8034.585328947151 10958.733493338983 8630.334533537909 10121.896929264209 7934.283324374745 5615.6658521954605 6945.550683063017 1.1271474729807276 1.2657824976762182 1.17124465923829 1.156796011659635 1.5778062810861437 1.242570233427754 1.4573210089657584 1.1423548234588208 0.8085270856765138 1.0 12.761873368534458 -8.050621435135511 5.118920279747864 0.9162678748781039 1.2864434511477858 0.5440428020353825 0.13828730098375946 0.1610703198605274 9.340705037799646 0.09619041005046151 0.03616819680348788 8.899765526598623e-09 8.050621435135511 0.3701755762696819 ERPES(ph)PMVPSEQVVEEAVPLPPQALTTSQDGHR ddPTM_A459_Selumetinib_30min_R2 9 ERPESPMVPSEQVVEEAVPLPPQALTTSQDGHR 33 1 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 ERPES(0.901)PMVPS(0.099)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.797)PMVPS(0.203)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.979)PMVPS(0.021)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.957)PMVPS(0.043)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.705)PMVPS(0.295)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.815)PMVPS(0.185)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.967)PMVPS(0.033)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.898)PMVPS(0.102)EQVVEEAVPLPPQALTTSQDGHR;ERPES(0.996)PMVPS(0.004)EQVVEEAVPLPPQALTTSQDGHR 90.211 5.876799999999999e-09 136136200.0 134400.4 116502.1 198651.5 245465.5 279421.0 181275.0 152854.69999999998 165884.9 192382.5 238082.0 True False 126930.96381542951 125437.43645670581 185870.47876539986 212032.67544839435 244317.63592456578 206243.98579938963 159962.74642584196 166367.59759527643 230864.37561617317 231207.95404867534 0.548990471965801 0.5425308007798813 0.8039103997532423 0.91706479701713 1.0567008255828885 0.8920280733766186 0.6918565889483439 0.7195582793845046 0.9985139852393234 1.0 17.81883150492761 -5.339014438397924 3.3310397713876307 0.881854770926645 0.5387328435154615 0.6067853321828649 0.11076667908760289 0.1792660291679282 3.819930325130454 0.0327145379445879 0.08134273019896945 4.581266557475614e-06 5.339014438397924 -0.3431219274111835 ERPIS(ph)LGIFPLPAGDGLLT(ph)PDAQK ddPTM_A459_Selumetinib_30min_R1 1 ERPISLGIFPLPAGDGLLTPDAQK 24 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3;D6RHI8 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 2 ERPIS(1)LGIFPLPAGDGLLT(1)PDAQK 97.289 3.1133e-05 4952100.0 665.04 658.35 831.12 757.93 711.96 651.72 567.46 596.74 248.22 493.29 True False 680.5341380574241 581.2700759413888 718.2584690153719 625.5717536081739 647.5633437067471 645.1642885144146 524.6560353353333 580.9125167153002 421.21121072849104 556.6085765514985 1.2226440028533405 1.0443067182735166 1.2904193346523423 1.1238988760898025 1.1634088495703108 1.1590987198069571 0.9425942348676533 1.0436643292749426 0.7567458146946462 1.0 9.120519328507102 -7.360522452241389 1.6767055437476075 0.9137277864368817 1.170870620648487 0.5967834298115302 0.09242350512839995 0.2568318631232827 1.403601771582629 0.050839203255252194 0.028573100593381237 4.359910234682238e-08 7.360522452241389 0.2571428342116052 ERPISLGIFPLPAGDGLLT(ph)PDAQK ddPTM_A459_Selumetinib_30min_R1 2 ERPISLGIFPLPAGDGLLTPDAQK 24 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3;D6RHI8 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 ERPISLGIFPLPAGDGLLT(1)PDAQK;ERPISLGIFPLPAGDGLLT(1)PDAQK 186.3 5.4597e-26 113240000.0 7302.700000000001 7957.8 7814.3 7813.9 6861.4 6876.9 6946.0 7136.5 4502.2 5553.799999999999 True False 7472.838701419392 7026.097076519149 6753.160980877393 6449.34905006915 6240.787581478559 6807.724629725616 6422.05762774332 6947.216837381002 7639.904572322187 6266.684328593143 1.1924709000137284 1.1211825437673661 1.0776290342349928 1.0291485436154106 0.9958675520009164 1.086335974937154 1.0247935416885852 1.1085953070402443 1.2191302723616413 1.0 12.613486606806392 -4.905148164992904 2.065980310559477 1.0665316087145842 1.2097041496887497 0.2861878692313168 0.061724449517910174 0.7301280872931716 4.308731934093721 0.01733663536779149 0.18107180885302457 1.2440901024676581e-05 4.905148164992904 0.14317254097416554 ERPISLGIFPLPAGDGLLT(ph)PDAQK ddPTM_A459_Selumetinib_30min_R2 2 ERPISLGIFPLPAGDGLLTPDAQK 24 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3;D6RHI8 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 ERPISLGIFPLPAGDGLLT(1)PDAQK;ERPISLGIFPLPAGDGLLT(1)PDAQK 126.18 1.9454e-07 211237000.0 218198.0 269388.0 279470.0 295900.0 276280.0 297810.0 245457.0 210410.0 216571.0 274810.0 True False 206071.42867580045 290049.19338105613 261489.20446392937 255597.9095440292 241571.23642546244 338830.6242499863 256871.2368638186 211022.25826474937 259891.251499332 266875.5212578712 0.7721630957553497 1.0868332622413621 0.9798171193500462 0.9577420526967518 0.9051831928490803 1.2696204681979348 0.9625132932878252 0.7907141774192432 0.9738294852760566 1.0 18.025807457026282 -10.678507509822948 3.52047395983771 1.0000252852657596 0.9719903531455848 0.004099238124178561 0.1339347714119926 60156125.321432576 81742958.44900948 19050.965525750544 0.03365296190946452 2.0964885274855432e-11 10.678507509822948 -0.028034932120174827 ERPLQQVS(ph)PVASVPWR ddPTM_A459_Selumetinib_30min_R2 2 ERPLQQVSPVASVPWR 16 1 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 ERPLQQVS(0.997)PVAS(0.003)VPWR;ERPLQQVS(0.999)PVAS(0.001)VPWR 120.9 0.00086203 28191000.0 46636.0 42093.0 44449.0 45575.0 51466.0 39821.0 36463.0 40460.0 39144.0 43445.0 True False 44044.15781869973 45321.39774967251 41589.19973241199 39367.60637873982 45000.380968122314 45305.98129095296 38158.601750063775 40577.731901486426 46973.89377474289 42190.629966333836 1.0439322156091275 1.07420528647799 0.9857449335456294 0.9330888495894313 1.0665965643089599 1.0738398864180276 0.9044330881172565 0.9617711784314568 1.1133726567303186 1.0 15.36463500876399 -5.260751708946386 24.975497690139786 1.002009679575043 1.0590687530717717 0.10788327423390576 0.06192735841253617 130.79204366757818 4750057.171839494 0.01645106513176249 0.03879333362249381 5.485905106658709e-06 5.260751708946386 0.057059073496728674 ERPS(ph)GPESPVQGPR ddPTM_A459_Selumetinib_30min_R1 1 ERPSGPESPVQGPR 14 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 ERPS(0.994)GPES(0.006)PVQGPR 156.2 0.0015316 30606000.0 4079.3 5131.2 5125.5 5486.8 4995.7 4202.8 4798.5 4351.8 2699.7 3510.1 True False 4174.33975306395 4530.436718569837 4429.485252356205 4528.6333799919885 4543.839817062471 4160.523647837078 4436.545281705487 4236.3761273614045 4581.1937217134255 3960.65552626936 1.0539517323274676 1.1438603252722581 1.1183717500745254 1.1434050121136439 1.1472443859166988 1.050463394314925 1.120154290692475 1.0696148905814469 1.156675628902412 1.0 11.951523514520115 -11.346133199978736 2.485040329291633 0.9593206159059168 1.1118923029145777 0.43909091078679796 0.03781344550861749 13078403.110377982 8467601.75517648 3185400.558792677 0.009081550586989413 4.506784583276733e-12 11.346133199978736 0.15257168700866097 ERPS(ph)SAIYPSDSFR ddPTM_A459_Selumetinib_30min_R1 1 ERPSSAIYPSDSFR 14 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 ERPS(0.5)S(0.5)AIYPSDSFR 168.55 0.00092097 18086000.0 2779.6 3375.6 3163.8 3004.5 2846.2 2790.9 3034.9 2918.3 1470.5 2245.6 True False 2844.3592718399127 2980.3831827261356 2734.173337509425 2479.8204764500115 2588.761712537422 2762.82607993445 2805.9750495879925 2840.8972040256413 2495.3310989293627 2533.844633996318 1.1225468340392515 1.1762296483133412 1.0790611629558176 0.9786789778578093 1.0216734198317796 1.0903691737314565 1.1073982247926848 1.121180504088385 0.9848003565213812 1.0 11.30711235111603 -5.421091684922292 5.211423464709256 1.050630179395843 1.147672018263238 0.41426269637473945 0.04922139813919722 0.23428643551544465 9.536353791751123 0.01380027462363846 0.02937700836848386 3.792349153535213e-06 5.421091684922292 0.09704183886739504 ERPSGPES(ph)PVQGPR ddPTM_A459_Selumetinib_30min_R1 3 ERPSGPESPVQGPR 14 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 ERPS(0.021)GPES(0.979)PVQGPR;ERPSGPES(1)PVQGPR;ERPSGPES(1)PVQGPR 126.43 0.0007139 51934500.0 5029.7 6235.0 6227.9 6905.799999999999 6903.0 5128.3 5855.3 5168.9 2708.1800000000003 4379.9 True False 5146.882223907469 5505.003301427139 5382.185387405948 5699.83166792095 6278.624868823635 5076.713958123845 5413.630006870922 5031.803981046549 4595.5836623587375 4942.102828838828 1.0414356807538856 1.1138989802688035 1.0890476329223848 1.1533211398719834 1.2704359027468535 1.0272376221108788 1.0954102321142682 1.0181504018257743 0.9298842661755164 1.0 12.270909313360448 -7.739553988352183 1.5935409970790653 0.9640205038544245 1.124012403216762 0.4710963413022805 0.06495318753500846 0.3576028044100823 1.720932573533516 0.05184242680618364 0.020699242158206926 1.821570614518489e-08 7.739553988352183 0.1599918993623375 ERPSGPES(ph)PVQGPR ddPTM_A459_Selumetinib_30min_R2 2 ERPSGPESPVQGPR 14 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 ERPS(0.363)GPES(0.637)PVQGPR;ERPSGPES(1)PVQGPR 95.554 0.0068285 98874000.0 69009.0 54085.0 87384.0 94139.0 125773.0 74832.0 68987.0 70799.0 75714.0 82512.0 True False 65173.75604491477 58233.145589315005 81761.8085765056 81317.10580116704 109972.27131511374 85139.42874273857 72195.03219514714 71005.01336859458 90858.9156259168 80129.66416807781 0.8133536652319928 0.7267364239436563 1.0203687913255726 1.0148190017444536 1.372428955704081 1.0625207234633158 0.900977596058718 0.8861264315254883 1.1338986200582795 1.0 16.29004880976835 -5.317815284860322 5.211514836313034 1.0522546744868222 0.7698176744416284 0.42557505923793326 0.1297296843660847 0.19425437339131763 11.427040773096763 0.03727210386499087 0.08204613201645851 4.81043903658224e-06 5.317815284860322 -0.2824370000451938 ERPSS(ph)AIYPSDSFR ddPTM_A459_Selumetinib_30min_R1 1 ERPSSAIYPSDSFR 14 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 ERPS(0.229)S(0.771)AIYPSDSFR 171.15 6.1082e-07 0.0 2103.6 2505.8 2075.2 2143.7 2081.8 2134.1 1959.5 2018.8 1219.7 1906.6 True False 2152.6097871069355 2212.419771085186 1793.3992382576519 1769.3430372327812 1893.501557571643 2112.6328916077655 1811.6933373974987 1965.2548660134203 2069.741816636614 2151.330681856689 1.0005945646854917 1.028395954998315 0.8336232329982264 0.8224412230786221 0.8801536525930413 0.9820121608568676 0.8421268532431895 0.9135066415346815 0.962075163103396 1.0 11.071013583671009 -10.146675752192927 14.399790030245528 0.9999956485732725 0.9146190606047482 0.10786602255901168 0.06973677682477339 0.0 0.0 0.07198804246980847 0.017459664875557085 7.133854507507459e-11 10.146675752192927 -0.08537658796852432 ERPSS(ph)AIYPSDSFR ddPTM_A459_Selumetinib_30min_R2 2 ERPSSAIYPSDSFR 14 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 ERPS(0.077)S(0.922)AIYPSDSFR;ERPS(0.196)S(0.804)AIYPSDSFR 136.39 0.0028268 14291300.0 32241.0 33064.0 33838.0 38441.0 32610.0 32216.0 36961.0 42689.0 33081.0 41101.0 True False 30449.174290949 35599.90248248336 31660.899920028758 33205.269485576224 28513.24026290113 36653.46157226941 38679.759736832064 42813.217922455624 39698.12436036859 39914.307336777245 0.7628636527256725 0.8919083120272873 0.7932218302797965 0.8319139602099701 0.7143613948331977 0.9183038368424027 0.9690700482529064 1.0726283575766153 0.9945838224227566 1.0 15.284618354667636 -7.109710679746261 2.6310569120694502 1.0188701416143873 0.8060093887587216 0.7864940390941884 0.051237715855706606 0.12537584096423807 1.6902575824260708 0.021355326889289795 0.015922992969962416 7.767644127167559e-08 7.109710679746261 -0.21286075285566564 ERPTPSLNNNCTT(ph)SEDSLVLYNR ddPTM_A459_Selumetinib_30min_R2 1 ERPTPSLNNNCTTSEDSLVLYNR 23 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 ERPTPSLNNNCT(0.039)T(0.778)S(0.162)EDS(0.021)LVLYNR 100.04 6.8922e-05 3302800.0 12230.0 12759.0 10974.0 14656.0 15245.0 8373.0 9536.6 14063.0 9559.0 9986.8 True False 11550.305560569033 13737.574273348817 10267.94478758779 12659.82751698981 13329.7868079708 9526.304747473669 9980.070796414406 14103.92100174503 11471.067100775772 9698.455135177423 1.1909428253861518 1.4164703637717557 1.058719625391137 1.3053447523895991 1.3744237223536888 0.9822497103606384 1.0290371669829694 1.4542440837395298 1.1827726107809562 1.0 13.243539243681543 -6.740375139180266 24.99731155533536 1.1517618643819032 1.2676798705838017 0.15934703937950734 0.1561374747119701 574.3896739680487 681637.0081970396 0.05312782738995727 0.05307506969358249 1.8181296980898773e-07 6.740375139180266 0.11591800620189852 ERPVS(ph)EMFSLEDSIIER ddPTM_A459_Selumetinib_30min_R1 2 ERPVSEMFSLEDSIIER 17 1 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 ERPVS(0.999)EMFSLEDSIIER;ERPVS(1)EMFSLEDSIIER 143.09 0.00027343 23991300.0 1891.74 1919.58 2324.0 2568.74 2148.3900000000003 2349.96 1897.33 2015.69 1275.48 1719.8899999999999 True False 1935.8138613147341 1694.8346812114692 2008.4135648182257 2120.1577802217357 1954.0685038290615 2326.3215359929645 1754.2128705508542 1962.2273533161238 2164.396402626606 1940.6546346472787 0.997505597726602 0.8733314269076587 1.0349155016875335 1.092496182664198 1.00691203315742 1.198730312163855 0.9039284163354955 1.0111162070178272 1.1152919040744171 1.0 10.922327678749335 -5.376084815187863 6.984701198947227 1.0472807888636113 0.9361216632529602 0.2356218859013438 0.07942387263440319 0.3259272669689214 17.55038228181513 0.020343553188031625 0.04271073474707215 4.2064447094220345e-06 5.376084815187863 -0.11115912561065111 ERQAQAQES(ph)EEEEESR ddPTM_A459_Selumetinib_30min_R1 1 ERQAQAQESEEEEESR 16 1 H0YLQ7;Q9NVM6 H0YLQ7 DNAJC17 DnaJ homolog subfamily C member 17 1 ERQAQAQES(0.999)EEEEES(0.001)R 70.11399999999999 0.023885 1016200.0 267.68 199.02 337.53 313.77 239.51 387.08 285.33 155.99 138.03 204.86 True False 273.9164231853892 175.7186458781122 291.6952799195763 258.97595969236806 217.84636278892498 383.1863266405199 263.80732837949904 151.8526384730699 234.22682868767066 231.15577650538205 1.184986277766723 0.760174149807677 1.261899158781285 1.1203525328571586 0.9424223183271945 1.657697386730018 1.141253454132723 0.6569277254013779 1.0132856389259088 1.0 7.852721605264603 -7.660209779681179 10.749073250572447 0.8766780040489675 1.1525784262171703 0.20807398267225297 0.23441941482857467 0.5528797530473455 54.14275543255348 0.1121755877851897 0.0646864572310263 2.1867051124605868e-08 7.660209779681179 0.2759004221682029 ERQEQLER ddPTM_A459_Selumetinib_30min_R2 1 ERQEQLER 8 1 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7;A0A0U1RQP7 A0A0U1RRM6 ENAH Protein enabled homolog 0 104.2 0.041707 2377500.0 14141.0 14386.0 14699.0 18216.0 14014.0 9962.6 14627.0 16108.0 12060.0 18834.0 False True 13355.099830908146 15489.359941719256 13753.282343061137 15734.949375647273 12253.43603325043 11334.85771852158 15307.18448285064 16154.871613177043 14472.336984554444 18290.21348339123 0.7301773619556433 0.8468660005409263 0.75194761152187 0.8602933689065841 0.6699449432002196 0.6197225488272408 0.8369057308571392 0.8832522172497754 0.7912612391154602 1.0 14.158784293872404 -8.752518416948703 0.7943542379390063 0.9967124574652418 0.7599129916990593 0.4403153104867701 0.07874491990452509 0.9702879626420975 1.240277430977509 0.0825280123023494 0.029286368824850077 1.7679972414077204e-09 8.752518416948703 -0.2367994657661825 ERS(ph)GSESSVDQK ddPTM_A459_Selumetinib_30min_R1 2 ERSGSESSVDQK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ERS(0.982)GS(0.012)ES(0.003)S(0.003)VDQK;ERS(0.963)GS(0.01)ES(0.005)S(0.022)VDQK 162.94 0.0023554 4328000.0 1308.1399999999999 1714.38 1923.02 1444.1599999999999 1734.78 1479.9 1366.49 1372.73 1534.6599999999999 1060.9099999999999 True False 1338.6171168026563 1513.6595926063605 1661.884446392747 1191.964566240655 1577.869455300285 1465.01354964169 1263.4145591325898 1336.3207411445426 2604.205932868368 1197.0881326385083 1.1182277063027959 1.2644512557902443 1.38827242629979 0.9957199756156963 1.3180896312308221 1.2238142787470843 1.0554064689856135 1.1163094050553746 2.1754504633910487 1.0 10.22531365569029 ERS(ph)GSESSVDQK ddPTM_A459_Selumetinib_30min_R2 1 ERSGSESSVDQK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 ERS(0.984)GS(0.01)ES(0.003)S(0.003)VDQK 120.29 0.014465 0.0 6009.0 4908.8 4748.8 2979.8 4231.1 4083.5 7023.3 13165.0 6895.1 6938.2 True False 5675.0438359328955 5285.28917572025 4443.267378102502 2573.946099558285 3699.551391486075 4645.965058677745 7349.89736640493 13203.30797041693 8274.312665190828 6737.876138391473 0.8422600414984317 0.7844147127616985 0.6594462834936053 0.38201148947994173 0.5490678836327296 0.6895296029865684 1.0908329591466137 1.9595652545742617 1.2280297968146008 1.0 12.718078192467138 -7.425452028943473 3.58929104077601 1.4577698320093517 0.6418045219963754 0.623250473677988 0.2592235028906265 0.14253454396435658 3.394376404310891 0.11772618390898808 0.07392199121209059 3.754464230324016e-08 7.425452028943473 -0.8159653100129763 ERS(ph)PDSFSMR ddPTM_A459_Selumetinib_30min_R2 1 ERSPDSFSMR 10 1 Q92834-2;Q92834;H7C4H4;A0A2R8YDN2;A0A2R8Y838;A0A2R8Y414;Q92834-5;Q92834-3;Q92834-6 Q92834-2 RPGR X-linked retinitis pigmentosa GTPase regulator 1 ERS(1)PDSFSMR 120.53 0.0027828 9781100.0 9271.5 9640.4 17756.0 19773.0 22421.0 16339.0 9017.8 11675.0 17794.0 13373.0 True False 8756.22714675518 10379.787681228294 16613.59829127107 17079.883289672453 19604.273533716827 18589.54893932548 9437.145568431706 11708.972317099702 21353.297205900628 12986.88674277323 0.6742360444182459 0.7992514208229544 1.2792595038619234 1.315163797757522 1.509543736078699 1.4314091827796946 0.7266672725611597 0.9015996326922121 1.6442198679974651 1.0 13.664768004401834 -5.182017305429641 4.30160982240916 1.2254926831060693 0.706759176743904 0.3504465211166512 0.2678748440811897 0.2609603707630357 8.901248877939764 0.07337536350174718 0.2134695109261527 6.576316320381585e-06 5.182017305429641 -0.5187335063621653 ERS(ph)PFGNPENVR ddPTM_A459_Selumetinib_30min_R2 1 ERSPFGNPENVR 12 1 K7ESB7;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 ERS(1)PFGNPENVR 79.337 0.023228 4485500.0 6628.4 4816.0 6621.1 8312.7 9785.9 7535.5 6857.3 5013.8 4896.0 6868.5 True False 6260.020063587554 5185.371714119277 6195.105634508606 7180.495919792661 8556.507754944005 8573.44672454172 7176.178037482168 5028.389327920725 5875.336805669859 6670.188558493826 0.9385072114064957 0.7773950719153536 0.9287751883145419 1.0765056874815044 1.282798481618355 1.2853379854793283 1.0758583471143428 0.7538601471044725 0.880835189912015 1.0 12.703511829963837 -5.614416859316854 4.150074215036308 1.0604389625879065 0.8565191317570207 0.2036260409156445 0.15615502307517 0.3660389398392272 11.636857646904849 0.05011714848497357 0.09141728197559834 2.429870568268497e-06 5.614416859316854 -0.20391983083088583 ERSDS(ph)GGSSSEPFDR ddPTM_A459_Selumetinib_30min_R1 2 ERSDSGGSSSEPFDR 15 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 ERSDS(0.853)GGS(0.073)S(0.073)S(0.001)EPFDR;ERS(0.003)DS(0.992)GGS(0.003)S(0.001)SEPFDR 205.33 1.7085e-05 50819000.0 3633.8 4789.4 5553.6 5675.0 4517.5 4096.4 4464.5 3862.8 2586.79 3430.2 True False 3718.460469856049 4228.654821468347 4799.451623741177 4683.967782943523 4108.892922629401 4055.1939352336117 4127.739170610429 3760.345995857263 4389.593698333549 3870.499582977453 0.9607184783612752 1.092534627846511 1.240008304056995 1.2101713700070456 1.061592395126564 1.047718478789779 1.0664615980749157 0.9715402147038982 1.1341155332089645 1.0 11.918304078258416 -6.493475802184831 21.223571347416147 1.0448232833355988 1.1321629288715946 0.1892394320018157 0.08031736006774742 183.6792718753729 132582.25916745438 0.02623225964734312 0.02965284838095737 3.2101416603873583e-07 6.493475802184831 0.08733964553599582 ERSDS(ph)GGSSSEPFDR ddPTM_A459_Selumetinib_30min_R2 2 ERSDSGGSSSEPFDR 15 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 ERS(0.006)DS(0.99)GGS(0.004)S(0.001)SEPFDR;ERS(0.095)DS(0.89)GGS(0.01)S(0.004)S(0.001)EPFDR 107.98 0.0022582 43285000.0 20130.7 21516.5 34237.0 31543.0 32371.0 19263.1 20419.3 27560.5 21816.0 25400.0 True False 19011.916283577022 23166.746363548045 32034.22869442709 27246.788985289946 28304.26557958822 21916.417171988553 21368.83791007536 27640.69649211361 26179.809589970126 24666.636002874442 0.7707543209930018 0.9391935876804761 1.2986865615033234 1.1046009266166184 1.1474716526521849 0.8885045033880825 0.8663053165249293 1.120570169718019 1.0613449514120754 1.0 14.590273356116024 -6.754978499840136 24.997499544366555 0.9873156450286472 1.0624778791350487 0.04470119984729626 0.14591081427345984 564.2319101436526 2183039.803159744 0.052889751224004175 0.05169246527107916 1.7580106437872396e-07 6.754978499840136 0.07516223410640144 ERSFHPEQDAGK ddPTM_A459_Selumetinib_30min_R1 2 ERSFHPEQDAGK 12 1 U3KQC1;K7EIR0;A0A0A0MQU0;Q9BV38;K7EML4 U3KQC1 WDR18 WD repeat-containing protein 18 0 ; 118.77 0.012515 23057000.0 12261.8 15378.7 12623.6 13056.3 13149.5 11797.599999999999 13284.6 13178.4 7154.099999999999 11618.1 False True 12547.476082690548 13578.154654636342 10909.384456471314 10776.262302104946 11960.130046732778 11678.926855363748 12282.531926507187 12828.8660225239 12139.98518520948 13109.396304877378 0.9571360717825147 1.0357574322155905 0.8321805369796056 0.8220258241865505 0.9123326329133087 0.8908821263583724 0.9369258233453088 0.9786008237275498 0.9260521920977225 1.0 13.678313629715285 -7.511864206166243 4.546899009341475 0.9638098285019314 0.907177107280855 0.1687655327681138 0.05930350833411818 0.42067605277508613 22.40683199925632 0.030376061103983346 0.01837966621367704 3.077058789411351e-08 7.511864206166243 -0.05663272122107643 ERSMS(ph)ENAVR ddPTM_A459_Selumetinib_30min_R1 1 ERSMSENAVR 10 1 A0A0A0MS29;Q9GZY8-2;C9JHF5;H7C433;Q9GZY8-4;Q9GZY8-3;Q9GZY8;Q9GZY8-5 A0A0A0MS29;Q9GZY8-5 MFF Mitochondrial fission factor 1 ERS(0.145)MS(0.855)ENAVR 123.95 0.01896 4315700.0 1427.7 1167.5 3217.0 2591.1 2592.6 2256.3 1477.3 1879.3 1161.6 1148.4 True False 1460.9626321793942 1030.8085572439754 2780.1490697161075 2138.6130259709184 2358.0997877607065 2233.6036705564875 1365.866071618947 1829.4548591732812 1971.150360092722 1295.8083263632761 1.1274527277345319 0.7954946239132216 2.1454940620104495 1.6504084612367003 1.8197905815119912 1.7237145533901308 1.0540648982031857 1.4118252074422917 1.5211743280156356 1.0 10.339636617810688 -7.253909973574224 24.74619723558294 1.2810848743799317 1.5544660246886155 0.1267254005010222 0.37699098824168825 1310.7506524035443 4307931.28101248 0.157035576754445 0.11917918768223192 5.573012618914304e-08 7.253909973574224 0.2733811503086838 ERTDVIQGDDVADATS(ph)EVEVSSTSETTPK ddPTM_A459_Selumetinib_30min_R1 1 ERTDVIQGDDVADATSEVEVSSTSETTPK 29 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 ERTDVIQGDDVADAT(0.014)S(0.974)EVEVS(0.008)S(0.003)T(0.001)SETTPK 146.63 1.0273e-15 3145900.0 388.52 422.82 630.88 718.62 591.98 537.76 649.28 303.63 303.8 442.39 True False 397.5717600716804 373.3160378363147 545.2099611757843 593.1265071680841 538.4355135225579 532.3506226470134 600.304286861673 295.57674607076234 515.5264113259026 499.1750657435126 0.7964575704107018 0.7478659561656329 1.092221944947718 1.1882134102283983 1.0786506588035754 1.0664607653310696 1.202592693542355 0.592130429492719 1.0327567354712217 1.0 8.963402061822245 -5.256495399410522 24.69627564139735 1.0316831401879019 0.7721617300564151 0.29600529401925557 0.16005759114704946 449.1906301991495 2243783.230784878 0.04315818196630773 0.10694812579458308 5.539934124975359e-06 5.256495399410522 -0.2595214101314868 ERTDVIQGDDVADATSEVEVSSTSET(ph)TPK ddPTM_A459_Selumetinib_30min_R1 2 ERTDVIQGDDVADATSEVEVSSTSETTPK 29 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 ERTDVIQGDDVADATS(0.001)EVEVS(0.07)S(0.07)T(0.07)S(0.07)ET(0.36)T(0.36)PK;ERTDVIQGDDVADATSEVEVS(0.017)S(0.025)T(0.025)S(0.025)ET(0.82)T(0.088)PK 99.378 1.4496e-07 13837900.0 1123.55 1312.77 1627.13 1498.9 1151.96 1141.98 1429.1599999999999 1398.3000000000002 666.9000000000001 1216.85 True False 1149.7265289522709 1159.070278109784 1406.1746831853177 1237.1452528377183 1047.7654213950561 1130.4927180348795 1321.357310576683 1361.212541681478 1131.6805915511675 1373.0445506227375 0.8373555893949822 0.8441607212119181 1.0241289567389158 0.9010233879713643 0.7630964493612734 0.8233474416559537 0.9623557443765303 0.9913826474633374 0.8242125800199996 1.0 10.423162721450641 -10.647529043651119 4.922207248864805 1.0000028296834609 0.8889025268176134 0.1556600811112293 0.07956066640481838 5.0580445729600085e-06 8.995685075628199e-07 0.08176506158361856 0.01982996626788969 2.251494841915772e-11 10.647529043651119 -0.11110030286584749 ERTS(ph)SLTQFPPSQSEER ddPTM_A459_Selumetinib_30min_R1 1 ERTSSLTQFPPSQSEER 17 1 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ERT(0.148)S(0.399)S(0.399)LT(0.055)QFPPSQSEER 80.016 0.0093755 5326300.0 1184.7 1158.1 1120.1 1237.8 1438.8 1284.5 1207.2 992.74 589.46 939.26 True False 1212.3012049750841 1022.5091136139165 967.9965722688869 1021.6414663836996 1308.6607940407719 1271.5790962326855 1116.139932077704 966.4093103260166 1000.270567544986 1059.8231701671632 1.1438712033290148 0.9647921864669544 0.9133566801678881 0.9639735147728076 1.2347916434345931 1.199803072839144 1.0531378851640487 0.9118590133989875 0.9438089255844594 1.0 10.049607858125835 -7.706995700113039 7.402653963757256 0.9461064160855387 1.0657488899928946 0.2181317399846886 0.100309508862312 0.3780831011489757 42.87472902834868 0.05449111408009282 0.03100841928520949 1.9633797158789065e-08 7.706995700113039 0.11964247390735594 ERTSS(ph)LTQFPPSQSEER ddPTM_A459_Selumetinib_30min_R1 2 ERTSSLTQFPPSQSEER 17 1 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3 Q9H6Z4 RANBP3 Ran-binding protein 3 1 ERT(0.021)S(0.021)S(0.956)LT(0.001)QFPPSQSEER;ERTS(0.044)S(0.955)LT(0.001)QFPPSQSEER 147.49 0.0017128 4776500.0 1328.73 1647.6799999999998 1796.49 1873.6100000000001 2496.0 1642.8400000000001 1926.82 1655.9 689.31 1495.1100000000001 True False 1359.6868237414906 1454.7688596143496 1552.5365254132068 1546.4191855155618 2270.2372407045923 1626.314521179374 1781.4784161083185 1611.9801528787514 1169.7087247895258 1687.0219321046645 0.805968670511116 0.8623295476659484 0.9202823602158635 0.916656242628872 1.3457070103838724 0.9640150434502328 1.0559900747027122 0.9555181958231604 0.6933571535316329 1.0 10.72026301414587 -1.6380340570179892 23.860121472632276 0.9605547603225066 0.004719642930263834 0.0 0.16356404896495325 0.0 0.0 0.03883018252294657 0.0 0.02301261347300171 1.6380340570179892 -0.9558351173922428 ERVDDSTGTVIS(ph)DVEEDAGELSR ddPTM_A459_Selumetinib_30min_R1 1 ERVDDSTGTVISDVEEDAGELSR 23 1 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 1 ERVDDSTGTVIS(1)DVEEDAGELSR 208.82 3.7019999999999994e-24 6796900.0 878.68 819.34 1017.0 996.55 1110.1 1187.2 1051.4 988.92 537.59 763.37 True False 899.1515343863483 723.411291899168 878.8969859811252 822.5212500603297 1009.6916510040728 1175.2578458913538 972.0920515130041 962.6906291351261 912.2509659798952 861.3559753534774 1.0438791395361953 0.8398517135755624 1.0203644150961504 0.9549144298009763 1.1722118147374812 1.3644275764257157 1.1285601764288957 1.117645499283921 1.059087058176536 1.0 9.750465777851456 -6.259535562256834 24.32950183084918 1.1568214863521262 0.959803217739579 0.4076913493503622 0.1024520832569543 110.83636194607443 1416408.7807172441 0.031536407359902 0.03865717902389835 5.50128871296316e-07 6.259535562256834 -0.19701826861254723 ERVDDSTGTVIS(ph)DVEEDAGELSR ddPTM_A459_Selumetinib_30min_R2 1 ERVDDSTGTVISDVEEDAGELSR 23 1 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 1 ERVDDSTGTVIS(0.999)DVEEDAGELSR 86.869 0.0046744 0.0 21364.0 17987.0 21324.0 15682.0 16400.0 13466.0 17357.0 13434.0 12945.0 15505.0 True False 20176.674406868096 19366.545062679288 19952.037055815734 13546.084547041095 14339.68538213979 15320.819267822824 18164.13489224302 13473.090715881583 15534.361713520495 15057.330363171981 1.3399901523192503 1.2861871656908725 1.3250713489434678 0.8996338806627255 0.9523391621407574 1.0174990452022823 1.206331697195794 0.8947861533831245 1.0316810044571554 1.0 13.878178385069118 -5.750771125447094 24.99998449969567 1.0032403712362785 1.3139934369304462 0.7534278055897554 0.08302295536583525 106.9408870082141 250602.90500377349 0.02336198332984505 0.03993905734210647 1.7751247307245008e-06 5.750771125447094 0.3107530656941677 ES(ph)ASPTIPNLDLLEAHTK ddPTM_A459_Selumetinib_30min_R2 1 ESASPTIPNLDLLEAHTK 18 0 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 ES(0.364)AS(0.364)PT(0.273)IPNLDLLEAHTK 125.35 0.00054896 22936000.0 45936.0 41022.0 46853.0 43107.0 43395.0 34310.0 39743.0 39171.0 33739.0 43953.0 True False 43383.06101637768 44168.25549348026 43838.528989689315 37235.75223627727 37943.3321437778 39035.89106483001 41591.128249260495 39284.98112489186 40487.74274642471 42683.962686391365 1.0163784776760945 1.0347740161332801 1.0270491826586208 0.8723593099791761 0.8889364940775523 0.9145329676074231 0.9743970716786496 0.9203686502475746 0.948546952959762 1.0 15.381406498603603 -5.739888957735095 24.9577836686008 0.9273191520591368 1.02693798178583 0.5936888179755543 0.03581617917715468 156.805570263228 181596.81022183245 0.009891707162484985 0.017112568504035464 1.8201661869705004e-06 5.739888957735095 0.09961882972669311 ES(ph)EELLK ddPTM_A459_Selumetinib_30min_R1 1 ESEELLK 7 0 O43303-2;O43303 O43303-2 CCP110 Centriolar coiled-coil protein of 110 kDa 1 ES(1)EELLK 96.331 0.023214 17928000.0 3756.2 3792.8 3971.3 4802.4 4212.6 4794.6 3417.0 3808.9 1616.8 3681.2 True False 3843.7121517071105 3348.737212775118 3432.0192727894228 3963.750992212861 3831.5710737949394 4746.37067714849 3159.2529389575157 3707.875598949134 2743.5915136001317 4153.717877924495 0.9253666870672771 0.8062023736788776 0.8262523776661292 0.9542658188893283 0.9224437447132244 1.1426800800251096 0.7605843805010928 0.8926642848459085 0.6605146507858239 1.0 12.020187515784155 ES(ph)EELLK ddPTM_A459_Selumetinib_30min_R2 4 ESEELLK 7 0 O43303-2;O43303 O43303-2 CCP110 Centriolar coiled-coil protein of 110 kDa 1 ES(1)EELLK;ES(1)EELLK;ES(1)EELLK;ES(1)EELLK 105.1 0.017692 45975800.0 206087.0 221006.0 209167.0 213902.0 190519.0 124981.0 151942.0 168731.0 148658.0 170771.0 True False 194633.5095716262 237956.44955370505 195709.42294381012 184768.17859846828 166584.29995852997 142195.99828544224 159007.60406736116 169221.97927507944 178393.75385156664 165840.3975136562 1.1736194105275164 1.434852141705162 1.1801070539986755 1.1141325115507725 1.0044856528085233 0.857426781515843 0.9587989805334831 1.02039057920821 1.075695406704972 1.0 17.339435954090682 -5.83635346929891 1.8438572988770963 0.9801730996501877 1.3026130879312774 0.7018094376170485 0.08204406130133939 0.18096704931954682 1.2560037934002382 0.02622566716831909 0.04965951848971011 1.4576274244028652e-06 5.83635346929891 0.32243998828108966 ES(ph)EQESEEEILAQK ddPTM_A459_Selumetinib_30min_R2 1 ESEQESEEEILAQK 14 0 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 ES(0.812)EQES(0.188)EEEILAQK 193.32 0.00011511 10033000.0 24960.0 20746.0 29752.0 27160.0 29413.0 25594.0 32897.0 32781.0 29506.0 22525.0 True False 23572.82312279665 22337.15149109605 27837.788711528327 23460.76114638669 25717.87598444374 29119.34118080034 34426.77568416886 32876.38728281329 35408.02446652264 21874.644723021524 1.0776322734050128 1.0211435099372275 1.2726052954922287 1.0725093569952195 1.175693425428642 1.331191502742638 1.5738210206420908 1.5029449711799527 1.6186788363816573 1.0 14.416971965157396 -6.854421280135633 2.7118231101139965 1.4653837217909846 1.1179069371850718 0.4034901074070749 0.1711985847120342 0.23602464751627106 3.52275934296074 0.06251869516799809 0.05490886727811109 1.3982303344473746e-07 6.854421280135633 -0.3474767846059128 ES(ph)ESESDETPPAAPQLIK ddPTM_A459_Selumetinib_30min_R2 1 ESESESDETPPAAPQLIK 18 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 ES(0.77)ES(0.23)ESDETPPAAPQLIK 169.15 1.0279000000000002e-07 3996200.0 52970.0 42269.0 59139.0 57315.0 58450.0 47457.0 47591.0 51774.0 41465.0 52340.0 True False 50026.13945571068 45510.89638374331 55334.0611256747 49508.59812611021 51106.98845037014 53993.7709782465 49804.07579977749 51924.6537683529 49759.15862890129 50828.80820434835 0.9842083893564713 0.8953760277198454 1.0886358165868018 0.9740263420513331 1.0054728854728092 1.0622671057163877 0.9798395350831146 1.0215595368594694 0.9789558399412648 1.0 15.63335878350453 -5.245946510063352 24.999657633553387 1.0134084529624883 0.9397922153091633 0.3517660826337412 0.040206877337948276 848.9617690053169 1369899.0489931724 0.009558186841019813 0.0251076167695671 5.676145114189817e-06 5.245946510063352 -0.07361623765332492 ES(ph)HSPFGLDSFNSTAK ddPTM_A459_Selumetinib_30min_R2 1 ESHSPFGLDSFNSTAK 16 0 Q7LBC6;Q7LBC6-2;Q7LBC6-3 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 ES(0.607)HS(0.393)PFGLDSFNSTAK 164.7 1.4993e-05 2649900.0 25378.0 22531.0 29281.0 36745.0 34974.0 26426.0 28065.0 27289.0 25836.0 29681.0 True False 23967.59235618324 24259.055251416423 27397.092338742303 31740.26761133941 30580.253448472977 30065.94162865632 29370.07810974247 27368.406472062856 31003.921918154923 28824.032409500625 0.8315142036921709 0.8416260052295962 0.9504947798251853 1.101173741425491 1.0609290544092467 1.0430858944894315 1.0189441120688534 0.9494995732464558 1.0756274999169022 1.0 14.814984558581923 -5.426161890209762 3.231175979126286 1.0341143276851918 0.8358110034185492 0.7926671536155967 0.04040431412191178 0.11009986192307843 2.1588225023121845 0.011561109455780113 0.026799954887314216 3.7483325111429254e-06 5.426161890209762 -0.19830332426664266 ES(ph)HTPVSIQEEIVGDFK ddPTM_A459_Selumetinib_30min_R2 1 ESHTPVSIQEEIVGDFK 17 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;A0A0A0MR81;F5H176 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 ES(0.592)HT(0.407)PVSIQEEIVGDFK 166.04 1.0175e-06 1619000.0 32296.0 28129.0 32576.0 32974.0 32164.0 26189.0 27346.0 33875.0 24513.0 27456.0 True False 30501.117611131434 30286.403851009378 30480.09562606704 28482.88431667727 28123.27077019172 29796.297029928082 28617.64318507102 33973.57064169184 29416.28495044634 26663.273940744897 1.143937450401461 1.1358846598627137 1.1431490256524557 1.0682440716011163 1.0547568476658735 1.1175033154647795 1.0732981721850594 1.2741710083012676 1.1032510492079703 1.0 14.702566317068678 ES(ph)IESEIR ddPTM_A459_Selumetinib_30min_R2 1 ESIESEIR 8 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 ES(0.999)IES(0.001)EIR 98.044 0.019779 2392600.0 20726.0 20791.0 14808.0 17704.0 21234.0 18718.0 20965.0 25406.0 19186.0 16522.0 True False 19574.131892751735 22385.60284639824 13855.269401731353 15292.684658896529 18566.395085631484 21296.234594913676 21939.9140413594 25479.927253810292 23023.7361016303 16044.966930688635 1.2199546423067407 1.395179120225053 0.8635274514172337 0.9531141276238319 1.1571476068373943 1.3272844180302503 1.3674016366712298 1.5880323944498598 1.434950673384912 1.0 13.969833195720701 -6.796954519972594 3.039363150468346 1.3913100410659032 1.105389134868261 0.24523372317736225 0.19330762877906102 0.3267781783785716 6.189491631814254 0.07412139520480125 0.06750471146547146 1.5960462790583207e-07 6.796954519972594 -0.2859209061976422 ES(ph)IESEIRR ddPTM_A459_Selumetinib_30min_R1 1 ESIESEIRR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 ES(1)IESEIRR 105.17 0.0071384 1809600.0 945.82 727.56 757.53 649.84 772.77 854.48 959.63 1016.9 378.6 819.64 True False 967.8557657546507 642.3769369665321 654.6615868144365 536.3576430075805 702.8730899436251 845.8847070057647 887.2443364974541 989.9285086432765 642.4565481500557 924.8487779696931 1.0465016430895548 0.6945751048909128 0.707857978956955 0.5799409111887875 0.7599870451109122 0.9146194785083924 0.9593399025138019 1.070367969579256 0.6946611851079385 1.0 9.853073679610711 -6.766316883294164 4.630861546510495 0.936347970232706 0.7400209986247815 0.25870500702629273 0.1427291016257918 0.25240400410839103 13.569433952991455 0.050048601319624235 0.04662222816315871 1.7127071734107339e-07 6.766316883294164 -0.19632697160792445 ES(ph)LCDSPHQNLSR ddPTM_A459_Selumetinib_30min_R2 1 ESLCDSPHQNLSR 13 0 O15042-2;O15042;C9J5L1;E7EW00;E7ET15;U3KPT1;C9JDJ7;H0Y8D9 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 ES(0.926)LCDS(0.074)PHQNLSR 146.84 0.00058932 25311000.0 44271.0 28528.0 32447.0 42971.0 40420.0 34391.0 33178.0 38432.0 37809.0 35607.0 True False 41810.595050854594 30716.005868022155 30359.39534562245 37118.27567089038 35342.07824061524 39128.048079585235 34720.842740959764 38543.83075723991 45371.85647172627 34578.933391903556 1.2091348965854536 0.88828667790008 0.8779737362497976 1.0734361077655854 1.022069646858754 1.1315574033508744 1.0041039249952526 1.1146622228164131 1.3121242334892207 1.0 15.077605748415603 -6.97547678477987 0.9454379805873802 1.1399311887156856 0.9932715932082758 0.1377086698019756 0.11919637184756016 0.989073901819693 1.8409582487868188 0.0791197892911585 0.05863488115691093 1.0580914747852788e-07 6.97547678477987 -0.1466595955074097 ES(ph)NRLSAPSYLAR ddPTM_A459_Selumetinib_30min_R1 1 ESNRLSAPSYLAR 13 1 H0YJH0;Q9H4B6 H0YJH0 SAV1 Protein salvador homolog 1 1 ES(0.993)NRLS(0.007)APSYLAR 106.3 0.003853 9265600.0 2259.0 2475.9 2830.4 2602.6 2574.8 1977.7 2306.3 2230.4 1380.9 1967.6 True False 2311.6303047511733 2186.020476985317 2446.0472262743133 2148.1047668526553 2341.9097946178613 1957.8061336079263 2132.333934187219 2171.242546639753 2343.2864430544414 2220.160626047007 1.0411995770175548 0.9846226670894185 1.1017433592764398 0.967544754037618 1.0548380000719264 0.8818308507226332 0.9604412893241137 0.9779664233148966 1.0554580671159184 1.0 11.116448342326835 ES(ph)NRLSAPSYLAR ddPTM_A459_Selumetinib_30min_R2 1 ESNRLSAPSYLAR 13 1 H0YJH0;Q9H4B6 H0YJH0 SAV1 Protein salvador homolog 1 1 ES(0.997)NRLS(0.003)APSYLAR 106.35 0.0038428 18927000.0 14945.0 15971.0 21898.0 18828.0 24025.0 16075.0 16524.0 17205.0 16868.0 22329.0 True False 14114.416729575169 17195.924345140993 20489.106520739686 16263.59391988839 21006.764713774897 18289.18533567889 17292.398741684825 17255.063701558924 20242.07133129885 21684.303752290693 0.650904769219724 0.7930125191741259 0.9448819180360012 0.7500168834413387 0.9687544019740906 0.8434296781950793 0.7974615620230872 0.7957398078661451 0.9334895675015856 1.0 14.404363500903877 -1.5228787452873098 0.039441960995573074 1.3659976385893229 3.107151797780014e-09 0.3589790593032096 0.08441193369757678 1058.6809258823857 3.1930092235708263 30.5936121273467 97.5031672555459 0.029999999999518374 1.5228787452873098 -1.365997635482171 ES(ph)PAHPEADGAPK ddPTM_A459_Selumetinib_30min_R2 2 ESPAHPEADGAPK 13 0 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 1 ES(1)PAHPEADGAPK;ES(1)PAHPEADGAPK 141.59 0.00082077 1449800.0 25730.0 20105.2 24351.0 26055.0 25652.0 23478.6 33976.0 30808.0 24818.0 20186.0 True False 24300.029605350875 21647.2041915928 22784.283171364154 22506.264052618015 22429.366428210345 26712.564032489576 35555.95132216679 30897.646179461026 29782.293472858386 19603.17773047337 1.239596454179783 1.1042701591151707 1.1622749885058543 1.1480926389618844 1.1441699267636405 1.3626649923682823 1.8137850817367556 1.5761549787629723 1.5192584530089457 1.0 14.25879991778765 -6.943903966622957 4.419668052579679 1.5335698997742113 1.1587147529847102 0.3608816959690676 0.1941903461254377 0.1858040108942244 7.539231138337513 0.06760075287194042 0.05832739365465415 1.1378788714974195e-07 6.943903966622957 -0.37485514678950116 ES(ph)PEGSYTDDANQEVR ddPTM_A459_Selumetinib_30min_R1 2 ESPEGSYTDDANQEVR 16 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 1 ES(0.937)PEGS(0.061)YT(0.001)DDANQEVR;ES(0.999)PEGS(0.001)YTDDANQEVR 289.59 1.4071999999999996e-74 24630300.0 3027.09 3745.2999999999997 2749.59 2491.17 3393.2700000000004 2918.78 3921.29 4081.58 2193.7 3984.38 True False 3097.6153073082014 3306.7985348572693 2376.2107804167567 2056.133924552497 3086.3493276304775 2889.419723240199 3625.50393825131 3973.323239559666 3722.5486784912223 4495.813984147778 0.6889998826086623 0.735528326242373 0.5285385002127015 0.4573440831409878 0.6864940005331477 0.6426911196567032 0.8064176923322056 0.883782837450479 0.8280032696230124 1.0 12.134366629451513 -7.412634529323304 1.3918514347698285 0.9126968229044579 0.6087657265326196 0.6994903506315338 0.08456503182902456 0.2705969684540604 1.0074275057944932 0.06089539894987384 0.03131942172967019 3.866922522702725e-08 7.412634529323304 -0.30393109637183824 ES(ph)PEGSYTDDANQEVR ddPTM_A459_Selumetinib_30min_R2 2 ESPEGSYTDDANQEVR 16 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 1 ES(1)PEGSYTDDANQEVR;ES(0.995)PEGS(0.004)YTDDANQEVR 268.17 2.3558e-50 77400000.0 33325.0 25572.0 36714.0 33877.0 39475.0 25800.0 37622.0 47958.0 33945.0 23321.0 True False 31472.92991054482 27533.29017306025 34351.86121118077 29262.894158915402 34515.79758902242 29353.715810918522 39371.49754657874 48097.5498401257 40734.94850254562 22647.662134765134 1.3896767676621473 1.2157232834551812 1.5167950231140717 1.2920933730283624 1.52403357943243 1.2961035729095989 1.738435398422065 2.1237313394168793 1.7986381225643475 1.0 14.467074511469564 -7.272153450519126 21.47623917361689 1.7588458071447637 1.3750873869981475 0.17725712552593142 0.28142329061824284 134.50725961163243 269613.0988403383 0.11046879707553976 0.07564449754859111 5.34375513598148e-08 7.272153450519126 -0.3837584201466162 ES(ph)PGAAATSSSGPQAQQHR ddPTM_A459_Selumetinib_30min_R1 4 ESPGAAATSSSGPQAQQHR 19 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 ES(1)PGAAATSSSGPQAQQHR;ES(1)PGAAATSSSGPQAQQHR;ES(1)PGAAATSSSGPQAQQHR;ES(0.999)PGAAAT(0.001)SSSGPQAQQHR 256.8 2.7046e-47 49096000.0 9388.36 10656.44 7359.5599999999995 6948.360000000001 9535.859999999999 7145.36 10656.369999999999 9343.49 3877.47 7946.04 True False 9607.090521431493 9408.77905075545 6360.172175169367 5734.9593628710945 8673.343146692818 7073.48416586779 9852.551431407288 9095.670293267158 6579.783390796074 8965.991634984013 1.0715034000194696 1.0493852140173479 0.7093662847456702 0.6396346992444323 0.9673601649203728 0.7889237971478882 1.0988802836893183 1.0144633927358528 0.7338600858295141 1.0 13.130247438057747 -7.236923613778337 24.97803403225913 0.9630062797228794 0.8656485106458163 0.07466192843025654 0.15583961110747085 2256.8358307932517 2299394.2635777947 0.06347601398430502 0.04914332003339089 5.795306186554626e-08 7.236923613778337 -0.09735776907706317 ES(ph)PGAAATSSSGPQAQQHR ddPTM_A459_Selumetinib_30min_R2 2 ESPGAAATSSSGPQAQQHR 19 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 ES(1)PGAAATSSSGPQAQQHR;ES(1)PGAAATSSSGPQAQQHR 151.39 1.4529e-05 88405000.0 27388.2 20384.4 31676.9 36435.0 33539.5 44952.0 50202.0 53611.4 48630.0 48003.4 True False 25866.073487651433 21947.817933823313 29638.84274120096 31472.490146119264 29325.968163065685 51143.72996637248 52536.4924733758 53767.40029815492 58357.35883572823 46617.417114188276 0.5548585719430377 0.47080724957503856 0.6357890371446643 0.6751229925293402 0.6290774988934374 1.0970948871126236 1.1269713280057727 1.1533757901355395 1.2518359542053399 1.0 15.508581452232015 -6.762238698246669 3.9899258053269837 1.1431066482200012 0.5865224313719474 0.9252237946733526 0.07583300634324756 0.05562887673816169 1.9792970686508982 0.028269966672748295 0.02639557098401179 1.728865873544244e-07 6.762238698246669 -0.5565842168480538 ES(ph)PGSSEFFQEAVSHGK ddPTM_A459_Selumetinib_30min_R1 1 ESPGSSEFFQEAVSHGK 17 0 Q8N108-17;Q8N108;Q8N108-13;Q8N108-12 Q8N108-17 MIER1 Mesoderm induction early response protein 1 1 ES(1)PGSSEFFQEAVSHGK 168.3 2.6144e-06 0.0 2225.0 2854.4 1206.8 1181.6 1561.3 1567.0 2477.2 2576.1 1184.6 2728.9 True False 2276.8381709036566 2520.2055210254425 1042.9231884778972 975.2557413790433 1420.0806906699033 1551.2374027221624 2290.342809594838 2507.773459647897 2010.179680239185 3079.180896736978 0.7394298182729155 0.8184662108342241 0.33870149999406907 0.3167257053369376 0.46118780880161 0.5037824846101169 0.7438156075928909 0.8144287535381232 0.6528293554852141 1.0 11.588330910459616 -7.339696088870101 4.004631287212321 0.7962330353414669 0.5209420985811175 0.39344162766125523 0.16676702697503779 0.28721669419377543 8.749369891255752 0.08060329417679943 0.05318250409972561 4.5740816329649156e-08 7.339696088870101 -0.27529093676034944 ES(ph)PGSSEFFQEAVSHGK ddPTM_A459_Selumetinib_30min_R2 3 ESPGSSEFFQEAVSHGK 17 0 Q8N108-17;Q8N108;Q8N108-13;Q8N108-12 Q8N108-17 MIER1 Mesoderm induction early response protein 1 1 ES(1)PGSSEFFQEAVSHGK;ES(0.965)PGS(0.01)S(0.025)EFFQEAVSHGK;ES(0.926)PGS(0.037)S(0.037)EFFQEAVSHGK 252.44 6.588299999999999e-31 11950900.0 105722.0 69250.0 98924.0 109946.0 117154.0 103509.0 123780.0 127730.0 113317.0 85149.0 True False 99846.39447869816 74561.25232615434 92559.33754030765 94971.16513257117 102436.06714995154 117766.42518885138 129536.01526541679 128101.67315316004 135983.56634152192 82690.52712632877 1.207470770214826 0.9016903739438606 1.1193463236593233 1.1485132388560169 1.2387884163981313 1.4241827846729787 1.5665157759548536 1.5491698699351053 1.6444878399889238 1.0 16.335434445939455 -6.546333492676613 1.640563193370195 1.4890677856017844 1.0689126516235308 0.4373701419078839 0.1806072628946428 0.2952149034150558 1.6199167627335096 0.06806365641578532 0.07329936567628237 2.84227769765209e-07 6.546333492676613 -0.42015513397825366 ES(ph)PSAAGPEDK ddPTM_A459_Selumetinib_30min_R2 2 ESPSAAGPEDK 11 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3;H0YF21 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 ES(0.969)PS(0.031)AAGPEDK;ES(0.984)PS(0.016)AAGPEDK 132.56 0.0019874000000000003 9206900.0 46293.0 37819.0 42575.0 51738.0 43581.0 48962.0 62845.0 64744.0 51439.0 46570.0 True False 43720.22038556191 40719.595692748546 39835.77085215511 44691.19514697182 38105.96516091668 55706.07106721673 65767.41702500502 64932.39432105377 61728.23732574589 45225.403096608774 0.9667182024263763 0.9003699890914163 0.8808273254537823 0.9881878786465252 0.8425787843066026 1.231742942085437 1.4542140593974406 1.435750482584924 1.3649018714965213 1.0 15.464845741276823 -6.8868449621301835 4.445122774289506 1.3493310431572247 0.9178549604506302 0.6971609087445871 0.1254557054012038 0.10776680614926056 3.6901103898099126 0.04306078894155212 0.03785709848141309 1.297642430938446e-07 6.8868449621301835 -0.43147608270659454 ES(ph)PSLASR ddPTM_A459_Selumetinib_30min_R1 3 ESPSLASR 8 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 ES(1)PSLASR;ES(1)PSLASR;ES(0.999)PS(0.001)LASR 161.9 0.00038796 79751000.0 16422.6 20233.9 11365.7 11389.2 13042.3 12558.7 16821.4 15366.5 8042.4 16150.699999999999 True False 16805.214627183108 17864.905581515082 9822.300367321213 9400.290021762183 11862.62626780509 12432.370880387256 15552.548255013166 14958.930502573416 13647.36540634444 18223.799666140163 0.9221575596228273 0.9803062977425117 0.5389820206140137 0.5158249209262287 0.6509414329134589 0.6822051991433276 0.8534196237851437 0.820845859624276 0.748875956516426 1.0 14.153536172277981 -8.934131549121357 0.6824139433912411 1.0000155153012984 0.7206711337516178 0.2204002060518876 0.14511289833010502 2.4608057068978364 2.0804635392911313 0.18087928606323658 0.06270093703129966 1.1637734654894875e-09 8.934131549121357 -0.27934438154968055 ES(ph)PSLASR ddPTM_A459_Selumetinib_30min_R2 4 ESPSLASR 8 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 ES(0.995)PS(0.005)LASR;ES(0.82)PS(0.052)LAS(0.128)R;ES(0.995)PS(0.005)LASR;ES(0.975)PS(0.025)LASR 166.07 0.00025869 296762000.0 659462.0 455255.0 581257.0 637948.0 755240.0 580898.0 720990.0 699210.0 609425.0 507813.0 True False 622811.7420755507 490171.5946244539 543859.5574447713 551058.381878316 660359.9992687347 660911.4266329826 754517.4636145816 701244.585339553 731327.0287572219 493151.1192333727 1.2629226981046737 0.9939581915305179 1.1028253535959267 1.1174229569527552 1.3390621525817408 1.340180323752284 1.5299923982480574 1.4219669346582273 1.4829673912007038 1.0 18.911670282420793 -6.325173254072681 2.7588636954927925 1.3903606182248338 1.1043217932353226 0.3578333346029796 0.14883061889934365 0.25533430702864063 3.826011970035495 0.046658545709549824 0.05611067483031481 4.7296254131277287e-07 6.325173254072681 -0.28603882498951116 ES(ph)PVSAPLEGLICR ddPTM_A459_Selumetinib_30min_R1 1 ESPVSAPLEGLICR 14 0 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 ES(1)PVSAPLEGLICR 162.72 2.1327e-06 0.0 712.8 991.52 600.66 523.51 634.41 504.82 843.92 489.98 269.91 684.81 True False 729.406853132641 875.4323774548578 519.0936711892064 432.0888059997821 577.0277275141826 499.74196913988624 780.2624349561103 476.98413872065373 458.0175565535693 772.7120341142763 0.9439568958813046 1.1329348305780238 0.6717815282690908 0.5591847763767072 0.7467564914730525 0.6467376552672912 1.009771299667267 0.6172857645052705 0.5927402917680368 1.0 9.59378705624337 -5.266692831538092 24.959328718764308 0.718303901047336 1.0384458707641135 0.3838834690635956 0.15541804277919438 367.33800625419985 1745242.9451986882 0.03971999931162353 0.08684891381302325 5.411369237731308e-06 5.266692831538092 0.32014196971677755 ES(ph)PVSAPLEGLICR ddPTM_A459_Selumetinib_30min_R2 1 ESPVSAPLEGLICR 14 0 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 ES(0.687)PVS(0.313)APLEGLICR 116.79 0.0033986999999999997 0.0 1265.4 2151.1 2395.7 2941.3 2466.1 2175.5 2925.6 3842.8 1072.9 2309.6 True False 1195.0741337975512 2316.0824531233343 2241.5632702409366 2540.689865974491 2156.286470786276 2475.155377777256 3061.64619696642 3853.9819117902157 1287.5099793307181 2242.9158469385343 0.5328216550918602 1.032621199892394 0.9993969561098586 1.1327620113088073 0.9613764483092386 1.1035435775068052 1.3650294553607132 1.718290910044933 0.5740340107222942 1.0 11.131159776917752 -4.502987384043819 1.1553450595131742 1.1541100669146076 8.367024996352079e-34 0.26004484578659826 0.2803487509870991 3.7922097258564706 2.7976755278259584 0.08523510557072796 6.172859470632402 3.140599924820194e-05 4.502987384043819 -1.1541100669146076 ES(ph)RQESDPEDDDVKKPALQSSVVATSK ddPTM_A459_Selumetinib_30min_R1 1 ESRQESDPEDDDVKKPALQSSVVATSK 27 3 Q9H307 Q9H307 PNN Pinin 1 ES(0.655)RQES(0.279)DPEDDDVKKPALQS(0.033)S(0.033)VVATSK 56.252 0.0061335 15864000.0 849.37 983.85 4012.5 5056.1 2107.5 1997.6 960.24 648.51 512.36 507.1 True False 869.1586684136812 868.6603846205437 3467.624539084823 4173.147049751673 1916.8769971093454 1977.5059576756819 887.8083237063403 631.3094081426408 869.4374987061873 572.1912245722896 1.5190003465421433 1.51812951215717 6.060254666919887 7.293273420736367 3.3500636059950106 3.4560228691970223 1.5515937427561444 1.103318927364784 1.519487649178975 1.0 9.160353561670142 -7.19163788792543 2.251955228265433 1.2079941927367488 4.1018183493818015 0.36480949972849464 1.67441621592881 0.391615283212182 3.887886739865568 0.8855786090721794 0.6093426761272811 6.43223809857041e-08 7.19163788792543 2.893824156645053 ES(ph)RSPQQSAALPR ddPTM_A459_Selumetinib_30min_R1 1 ESRSPQQSAALPR 13 1 E5RJN3;A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4 E5RJN3 NCAPH2 Condensin-2 complex subunit H2 1 ES(0.996)RS(0.004)PQQSAALPR 98.407 0.0069189 11086000.0 1032.1 1209.6 1378.6 1424.8 1145.6 1213.3 1368.0 982.57 782.33 1111.5 True False 1056.1459218829948 1067.979469672216 1191.393692107747 1175.9854268084462 1041.9806822721077 1201.0953035882574 1264.810658616881 956.5090517628324 1327.556870877529 1254.1718519268384 0.8421062235294089 0.851541571461226 0.9499445313474046 0.937658922102046 0.8308117270143385 0.9576800035361683 1.008482734382611 0.7626618714917787 1.0585127300042223 1.0 10.292519330517859 -1.5228788719398472 0.06687374583316699 1.1033365467347773 0.49269963071530004 0.2000501442803413 0.07975065033702683 508.78915004520286 2.531801057675123 4.234284354771597 29.519263109606438 0.029999991250672316 1.5228788719398472 -0.6106369160194773 ES(ph)RSPQQSAALPR ddPTM_A459_Selumetinib_30min_R2 1 ESRSPQQSAALPR 13 1 E5RJN3;A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4 E5RJN3 NCAPH2 Condensin-2 complex subunit H2 1 ES(0.961)RS(0.039)PQQSAALPR 101.56 0.0055104 7121300.0 9059.2 9225.5 11476.0 9321.0 9827.8 7682.5 7334.9 10411.0 2449.4 8064.1 True False 8555.725930850946 9933.066185342075 10737.646654124053 8051.463720378139 8593.14390235325 8740.694640208589 7675.987383828621 10441.294286366172 2939.3484419541987 7831.268479951956 1.0925083149369226 1.2683853466102868 1.371124828833595 1.0281174424028348 1.097286336734808 1.1161275676583895 0.9801716546277459 1.3332826365353048 0.3753349089587376 1.0 12.935030293521624 -8.251047344661865 24.999992276412918 0.6876674275432197 1.1574075213117767 0.5117875157254032 0.18484738817734991 470.9744990207813 1133024.3770317219 0.12134138019754845 0.0447557881327772 5.6098681665787364e-09 8.251047344661865 0.46974009376855697 ES(ph)SPEKEAEEGCPEK ddPTM_A459_Selumetinib_30min_R1 1 ESSPEKEAEEGCPEK 15 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.772)S(0.228)PEKEAEEGCPEK 193.31 0.00014712 16709000.0 3818.3 4998.4 2772.2 3328.7 2527.4 3359.4 3797.3 4127.9 2310.8 5029.9 True False 3907.2589608815447 4413.18500430688 2395.750466604596 2747.4050324377295 2298.7971162487115 3325.6074860911503 3510.866603776231 4018.414682691102 3921.258825845611 5675.53666037499 0.6884386789642175 0.7775802128314144 0.4221187545718903 0.48407845757024937 0.40503607919551826 0.5859547184867313 0.6185964101488622 0.708023738221365 0.6909053822562268 1.0 12.470541100088688 -8.687350139193406 0.8245845262956206 0.9968420394571531 0.5576715134468654 0.5782422633844889 0.1102933704868771 0.6617781422440149 0.9455133271208237 0.11872705757842178 0.041979869550535766 2.054233752982033e-09 8.687350139193406 -0.4391705260102877 ES(ph)SPEKEAEEGCPEKESEEGCPK ddPTM_A459_Selumetinib_30min_R1 1 ESSPEKEAEEGCPEKESEEGCPK 23 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.546)S(0.454)PEKEAEEGCPEKESEEGCPK 51.684 0.014181 129560000.0 1585.6 1808.7 2015.6 2289.3 1279.2 2060.4 1531.5 1755.2 1349.9 1504.5 True False 1622.5413949594783 1596.9365631581823 1741.8925908982842 1889.5167304832805 1163.4965858611026 2039.6742466935177 1415.9777219822763 1708.646394306892 2290.6817072048584 1697.6172300710116 0.9557757580556644 0.9406929517859466 1.0260808856336954 1.1130404999507704 0.6853703916591571 1.201492427482135 0.8340971668407523 1.0064968498437183 1.3493511179248805 1.0 10.729295488824206 -8.027322624041338 23.143298268570263 1.1757586277515277 0.9670329106313927 0.2223847621163556 0.15447582202291069 402.25569515782837 340720.8128758126 0.09569598359541688 0.03645225046625868 9.390254781902139e-09 8.027322624041338 -0.208725717120135 ES(ph)SPEKEAEEGCPEKESEEGCPK ddPTM_A459_Selumetinib_30min_R2 1 ESSPEKEAEEGCPEKESEEGCPK 23 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.533)S(0.467)PEKEAEEGCPEKESEEGCPK 78.987 0.00075271 85945000.0 32300.0 26373.0 26742.0 29963.0 19179.0 17848.0 23268.0 24859.0 13308.0 20349.0 True False 30504.89530714471 28395.72429743931 25021.448834488107 25881.987710941987 16769.562557564564 20306.399991987357 24350.008104667315 24931.335574371016 15969.971856587925 19761.47149694851 1.5436550517938483 1.436923576355337 1.2661733635752692 1.3097196590313926 0.848598878891891 1.0275752994974585 1.232196099790815 1.261613315497321 0.8081367755965919 1.0 14.270402757762975 -5.576278882357288 1.3006387975227809 1.0583626185440893 1.5261188683864069 0.5894551016837093 0.14823179453572982 0.4000126350935088 1.257561787902344 0.05090523956456748 0.16921126048413704 2.6529014532675685e-06 5.576278882357288 0.46775624984231756 ES(ph)SPFLSPLEASR ddPTM_A459_Selumetinib_30min_R1 1 ESSPFLSPLEASR 13 0 Q9UP95-3;Q9UP95-5;Q9UP95-2;Q9UP95-6;Q9UP95;Q9UP95-4 Q9UP95-3 SLC12A4 Solute carrier family 12 member 4 1 ES(0.991)S(0.009)PFLSPLEASR 169.09 0.00026296 4872000.0 1760.3 1687.7 2324.7 1888.2 1981.9 1970.1 1981.1 1991.1 996.06 1862.2 True False 1801.3115650524537 1490.103299409557 2009.01850866305 1558.4613159037829 1802.6374949328656 1950.2825827076792 1831.6640320072404 1938.289559995701 1690.241070655953 2101.2315093640664 0.857264683603387 0.7091571265560042 0.9561147830260148 0.7416894849323139 0.8578957087305579 0.9281616870945975 0.8717097682213941 0.9224540710330013 0.8044049706676545 1.0 11.037019408601275 -6.522018395329506 23.37712936620059 0.8978007354036273 0.8160959627607968 0.22669577449288425 0.07723350549267843 21.860130246435755 594035.4641021419 0.023679646459022964 0.02400285950190981 3.005948977517483e-07 6.522018395329506 -0.08170477264283049 ES(ph)SPIPSPTSDR ddPTM_A459_Selumetinib_30min_R1 1 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ES(0.949)S(0.051)PIPSPTSDR 145.23 0.00068885 5015000.0 5855.0 6021.6 5029.0 4571.4 5397.8 4961.5 5718.8 4745.5 3184.6 5021.6 True False 5991.41010815322 5316.588272634109 4346.089422319645 3773.0908058058185 4909.569943058994 4911.591814681562 5287.426311767705 4619.633924443571 5404.033606018667 5666.171274526148 1.057400106327402 0.9383034883778245 0.7670240117623519 0.6658977681752755 0.8664704445365662 0.8668272766061611 0.9331568100559902 0.8153007914201998 0.9537363669739399 1.0 12.468158496186588 -8.446468150708618 4.496457824770473 0.999241278145245 0.8592743965479416 0.17659152919989918 0.0995134925854767 0.35827224197420104 12.687223052197494 0.10325980609684386 0.02697310219317714 3.5771063257550256e-09 8.446468150708618 -0.13996688159730342 ES(ph)SPIPSPTSDRK ddPTM_A459_Selumetinib_30min_R2 2 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ES(0.593)S(0.407)PIPSPTSDRK;ES(0.576)S(0.424)PIPSPTSDRK 128.95 0.00091104 16589700.0 74159.0 57369.0 50548.0 69888.0 68054.0 62973.0 50320.0 54831.0 54927.0 70133.0 True False 70037.5396619982 61769.017829590695 47295.7967125011 60369.133836475514 59504.44810952076 71646.9591380222 52659.979707188395 54990.54913223931 65913.93478860865 68108.07806258244 1.028329408996725 0.9069264555201958 0.6944227183894754 0.8863725941731045 0.8736768060734871 1.0519597847437125 0.7731825828178669 0.8074012759794832 0.9677843900989591 1.0 16.055538300983116 -6.557755192488076 24.999740716311603 0.905955731313611 0.869346574391094 0.02532018100692135 0.10904219857401423 962.1354962837102 689660.7250216426 0.03739462574980331 0.03739473584499743 2.768501782776403e-07 6.557755192488076 -0.03660915692251698 ES(ph)SPLSSR ddPTM_A459_Selumetinib_30min_R2 2 ESSPLSSR 8 0 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7;A0A0A0MS66;Q14693-6 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 ES(0.937)S(0.063)PLSSR;ES(0.5)S(0.5)PLSSR 148.69 0.0015317 27787800.0 180925.0 156327.0 204651.0 203860.0 218303.0 168800.0 198281.0 211052.0 161985.0 174282.0 True False 170869.91280015977 168316.77822946923 191483.9774671608 176093.91632188452 190877.8254864183 192050.66778616444 207501.45938634776 211666.12637846053 194386.52623905853 169250.02582098314 1.0095709703518154 0.9944859825752641 1.1313674933774878 1.0404365699071751 1.127786093742231 1.1347157369966827 1.2260054814161354 1.2506120773201015 1.1485169665182942 1.0 17.368796528336354 -5.925561928557694 0.8503860915269431 1.1730424422687937 1.0021659472033972 0.3370522518328498 0.07113642534561222 0.7326394483779222 1.0345969823073724 0.0327311426722173 0.08548172305093638 1.186965432721087e-06 5.925561928557694 -0.17087649506539648 ES(ph)SPLYS(ph)PTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R1 2 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.849)S(0.151)PLYS(0.558)PT(0.136)FS(0.224)DS(0.034)T(0.045)S(0.005)AVK;ES(0.5)S(0.5)PLY(0.005)S(0.993)PT(0.001)FS(0.001)DSTSAVK 166.34 5.8986e-07 33316000.0 6229.7 7004.179999999999 7786.599999999999 8294.130000000001 6947.85 6814.82 6584.01 6837.02 4139.13 5496.44 True False 6374.839889113936 6184.127349445058 6729.222488732179 6845.715895602711 6319.418194242549 6746.269098161483 6087.372824883139 6655.68001982914 7023.801299905802 6201.961613859422 1.0278747735020135 0.9971244155438643 1.0850151786967683 1.1037984950285247 1.018938617762588 1.0877637622080256 0.9815237829398665 1.0731572418887279 1.1325128624159537 1.0 12.59850888128885 -5.255328390613589 24.918060099447903 1.061189704460025 1.012499593127017 0.15030001275291194 0.045462450805222425 877.659147459941 3578703.329363865 0.011485034560268491 0.028989177775972656 5.554840706312063e-06 5.255328390613589 -0.048690111333007824 ES(ph)SPLYS(ph)PTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R2 2 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.51)S(0.486)PLY(0.201)S(0.791)PTFS(0.011)DSTSAVK;ES(0.568)S(0.432)PLYS(0.81)PT(0.162)FS(0.024)DS(0.004)T(0.001)S(0.001)AVK 120.9 0.005531800000000001 6615700.0 43191.0 39134.0 42119.0 49943.0 46072.0 33160.0 39712.0 38257.0 36215.0 50012.0 True False 40790.61712727204 42135.4519643571 39409.109395699816 43140.67724351952 40284.02347109416 37727.489003490606 41558.68668783516 38368.321536212716 43459.011931645 48568.02361321875 0.8398656995416643 0.8675554167060876 0.8114208992637256 0.8882526821984564 0.829435098942961 0.7767968757374414 0.8556800049925057 0.7899914116696735 0.8948070911375683 1.0 15.567719159272787 -8.568451442419216 5.130827234868337 0.9999709671552901 0.8337964308230326 0.7208835807622013 0.032134214336395524 0.13612149478488345 12.50343507514685 0.030505453659498367 0.007929578203053645 2.701149101416917e-09 8.568451442419216 -0.16617453633225754 ES(ph)SPLYSPTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R1 2 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ES(0.651)S(0.349)PLYSPTFSDSTSAVK;ES(0.576)S(0.422)PLY(0.002)SPTFSDSTSAVK 198.24 1.4465e-10 138329000.0 8157.900000000001 8892.6 10154.2 10707.400000000001 9381.3 8407.9 8075.299999999999 8410.4 4855.9 6882.7 True False 8347.963197489862 7851.450257942415 8775.315413028064 8837.553592791102 8532.763071403038 8323.324159762396 7466.173619538671 8187.3288711706255 8240.107639096283 7766.161588175308 1.0749149502890076 1.0109820879721287 1.1299424192240972 1.1379564399287143 1.0987104729310488 1.071742335677823 0.9613724276490209 1.0542310738984086 1.0610270653706975 1.0 12.922986009940143 -7.017775498389436 23.70653202762675 1.0226598119638568 1.0903426539875667 0.39914978572007875 0.041448460961362475 442.91906682844814 590704.1891642789 0.01669400755248944 0.013224032310237749 9.598967065893174e-08 7.017775498389436 0.06768284202370989 ES(ph)SPLYSPTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R2 3 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ES(0.495)S(0.495)PLY(0.01)SPTFSDSTSAVK;ES(0.86)S(0.138)PLY(0.002)SPTFSDSTSAVK;ES(0.9)S(0.1)PLYSPTFSDSTSAVK 154.72 2.4907e-05 153743000.0 490310.0 487878.0 525019.0 579914.0 608600.0 456016.0 451152.0 454642.0 346451.0 474645.0 True False 463060.5330664432 525296.6738249768 491239.84913746535 500928.71279255196 532142.227046968 518828.0646989078 472131.4619407283 455964.9329499652 415750.8806497402 460940.76557418733 1.004598785029602 1.1396186084140816 1.065733139323303 1.0867528979966703 1.1544698729002325 1.1255851151559813 1.0242779489303813 0.9892050497681111 0.9019616221877127 1.0 18.814221839618348 -7.603978384323143 2.421768258499527 0.9544158431816749 1.098398567163132 0.6220470846042654 0.0464494003839507 0.18475225386212857 2.1742272894385577 0.02661184088469314 0.013345328938122849 2.4889811966106297e-08 7.603978384323143 0.14398272398145706 ES(ph)SPPREEAPPPPPPTEDSCAK ddPTM_A459_Selumetinib_30min_R1 1 ESSPPREEAPPPPPPTEDSCAK 22 1 C9JR56;Q9UPW6-2;Q9UPW6 C9JR56 SATB2 DNA-binding protein SATB;DNA-binding protein SATB2 1 ES(0.508)S(0.492)PPREEAPPPPPPTEDSCAK 90.968 0.00021056 5889600.0 595.63 652.53 548.48 765.84 805.45 590.37 696.82 614.2 345.71 640.62 True False 609.5070201057732 576.1314842470329 473.99942858498275 632.1004205972636 732.5971897137473 584.4314138130717 644.2583063869998 597.9094207972278 586.644620340612 722.849817167226 0.8432000750783455 0.7970279172302109 0.6557370802728258 0.8744560842173276 1.0134846441335772 0.8085101495956633 0.8912754642614171 0.8271558027646368 0.8115719287854453 1.0 9.497552126668243 -5.959563368043071 24.799037261794552 0.8850398551401302 0.7679261333741816 0.33753258689746923 0.0796599904972289 169.99373237557685 104252.84986395486 0.02254531214399711 0.033440056103017424 1.0975811301850594e-06 5.959563368043071 -0.11711372176594859 ES(ph)SPSHGLLK ddPTM_A459_Selumetinib_30min_R1 1 ESSPSHGLLK 10 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 ES(0.5)S(0.5)PS(0.001)HGLLK 94.538 0.015694999999999997 14164000.0 8589.7 8507.0 8605.9 9450.6 9849.1 7715.3 10339.0 9030.7 3030.6 6619.2 True False 8789.823297353327 7510.996485202998 7437.266048824937 7800.230119733229 8958.250643999841 7637.6910869319045 9559.120906023343 8791.176500152269 5142.7068537336445 7468.838796467949 1.1768661149187043 1.0056444769908524 0.9957727367662638 1.0443698588623973 1.1994167886226494 1.0226075692708494 1.2798670806155168 1.1770472947293575 0.688555074473646 1.0 12.866668244838642 -8.24952475688679 24.96920180599939 0.8442775239842973 1.108415146678377 0.4691273064144442 0.11414325999374908 564.6578832648568 1183346.9337516266 0.07835749215969094 0.029106799414511473 5.6295702520525785e-09 8.24952475688679 0.2641376226940796 ES(ph)SPSHGLLK ddPTM_A459_Selumetinib_30min_R2 1 ESSPSHGLLK 10 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 ES(0.417)S(0.417)PS(0.167)HGLLK 72.34 0.045276 11113000.0 38546.0 31614.0 42698.0 51709.0 52574.0 38770.0 40331.0 43214.0 34391.0 36473.0 True False 36403.76763186377 34038.69214496822 39950.857166067384 44666.14499699958 45969.184102476655 44110.21558098104 42206.47141436039 43339.745585537166 41270.16096482686 35419.92972176534 1.0277763936243463 0.9610039436089464 1.1279202832951365 1.2610455567773897 1.2978338597388257 1.2453501722753442 1.1916023477715927 1.2235977294699472 1.1651677823478737 1.0 15.112273729127667 -5.4589904628371695 3.8560819186050748 1.2125776679206637 0.9969664985443453 0.5058633524567606 0.07837183576424606 0.15964467876518743 4.633021390527926 0.020366563571306756 0.04406051980627159 3.475437934659302e-06 5.4589904628371695 -0.2156111693763184 ES(ph)TGNMVTGQTVCK ddPTM_A459_Selumetinib_30min_R1 2 ESTGNMVTGQTVCK 14 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 ES(0.995)T(0.005)GNMVTGQTVCK;ES(0.845)T(0.155)GNMVTGQTVCK 175.27 7.049899999999999e-05 21228700.0 3836.8 4067.1 4243.1 4140.8 3483.8 3806.1 4765.1 3721.7 2322.6 3079.6000000000004 True False 3926.189974886811 3590.9220412565087 3666.9103256799553 3417.687012442741 3168.690905114848 3767.8140896623004 4405.664670595978 3622.9884262146547 3941.282564007711 3474.8966578442582 1.129872442687986 1.033389592507833 1.0552573750365335 0.9835363030804465 0.911880616064314 1.0842952929713199 1.2678548758135288 1.0426176036159502 1.1342157629668295 1.0 11.762754357913328 -6.991525013303795 24.95855258220655 1.1234880428685372 1.0205083998456628 0.1987025835605678 0.08321480200423656 270.35675324072474 796187.3242066288 0.02936871075132593 0.025859110523726223 1.0197060281191269e-07 6.991525013303795 -0.10297964302287443 ES(ph)TGNMVTGQTVCK ddPTM_A459_Selumetinib_30min_R2 1 ESTGNMVTGQTVCK 14 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 ES(0.878)T(0.122)GNMVTGQTVCK 141.86 0.00055084 9847200.0 48304.0 48173.0 55047.0 54773.0 58976.0 44793.0 49558.0 46170.0 34829.0 61338.0 True False 45619.45705623276 51867.71419939122 51505.33595064195 47312.82291130478 51566.90762787051 50962.829159630746 51862.54519731402 46304.347056145045 41795.773203569355 59567.01256473668 0.7658510153863114 0.8707456017375732 0.8646620626587006 0.794278928457018 0.8656957165986501 0.8555545588969228 0.8706588254858418 0.7773488221492065 0.701659717417358 1.0 15.862225985666095 -10.021310120365643 7.400102263306188 0.9999999963192735 0.8234797153853058 0.49426551576583455 0.0548715124186108 0.0 0.0 0.054884239528292265 0.01331138333863818 9.521160355999925e-11 10.021310120365643 -0.17652028093396765 ES(ph)VSPEDSEK ddPTM_A459_Selumetinib_30min_R1 1 ESVSPEDSEK 10 0 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 ES(0.493)VS(0.493)PEDS(0.014)EK 87.713 0.033267000000000005 17918000.0 4775.6 8596.2 7942.3 8383.3 6279.9 7403.2 7376.8 5563.4 3079.0 4891.4 True False 4886.862188300001 7589.752907735041 6863.779283931064 6919.314029030917 5711.884153806394 7328.730529567779 6820.362036904249 5415.840559529951 5224.838118737508 5519.258836270746 0.8854200053429562 1.3751398752777624 1.243605253448991 1.2536672466888978 1.0349005769161936 1.3278468625906403 1.2357387539216467 0.9812622890484562 0.9466557510225101 1.0 12.430258829740147 -7.7677046559946925 24.257769063671336 0.9729691105200053 1.2040044491922517 0.35289546663702975 0.13462911083045492 108.8151792289849 421295.2311753319 0.06861892420430049 0.034295730918873786 1.7072430129562104e-08 7.7677046559946925 0.23103533867224635 ESAAPAAAPTAEAPPPS(ph)VVTRPEPQALPSPAIR ddPTM_A459_Selumetinib_30min_R1 2 ESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIR 33 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 ESAAPAAAPTAEAPPPS(0.478)VVT(0.478)RPEPQALPS(0.043)PAIR;ESAAPAAAPTAEAPPPS(0.486)VVT(0.486)RPEPQALPS(0.027)PAIR 85.0 1.6914000000000002e-08 204340000.0 4647.1 6137.6 6157.700000000001 7200.9 6213.2 5539.8 6501.5 5595.0 3581.4 4779.8 True False 4755.368388317478 5419.0069387071735 5321.518161824949 5943.397992634011 5651.217157029555 5484.07464173595 6011.086620612317 5446.602424878685 6077.374224893314 5393.333889194691 0.8817122184563152 1.0047601446600436 0.9866843535287845 1.1019896254784725 1.0478151868831116 1.016824612457807 1.1145400496444817 1.0098767361298946 1.1268307043012982 1.0 12.39696163528686 -3.688836798058495 0.8436529069267776 1.0595906647861435 2.5072349566023436e-12 0.5687018785199809 0.04549796668569922 8.478787403805052 1.1495318768311884 0.014750788153930756 12.83008939196358 0.00020472138072136922 3.688836798058495 -1.0595906647836362 ESAAPAAAPTAEAPPPS(ph)VVTRPEPQALPSPAIR ddPTM_A459_Selumetinib_30min_R2 2 ESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIR 33 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 ESAAPAAAPT(0.019)AEAPPPS(0.39)VVT(0.39)RPEPQALPS(0.202)PAIR;ESAAPAAAPT(0.061)AEAPPPS(0.358)VVT(0.358)RPEPQALPS(0.223)PAIR 56.854 0.00057534 74630000.0 103533.0 84495.0 98781.0 129366.0 118176.0 92534.0 91801.0 91303.0 80171.0 105086.0 True False 97779.05033543699 90975.49480575325 92425.53800462083 111746.12763120263 103329.67437315556 105279.71855998195 96069.92840023045 91568.67661397456 96207.44016490159 102051.89413378199 0.9581306762151456 0.8914630696270227 0.9056719504241464 1.094993175577048 1.0125208870469224 1.0316292456264313 0.9413830994091138 0.8972756203224924 0.9427305684182719 1.0 16.63894343419161 ESAAPAAAPTAEAPPPSVVT(ph)RPEPQALPSPAIR ddPTM_A459_Selumetinib_30min_R2 1 ESAAPAAAPTAEAPPPSVVTRPEPQALPSPAIR 33 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 ESAAPAAAPT(0.022)AEAPPPS(0.37)VVT(0.405)RPEPQALPS(0.203)PAIR 61.499 0.00070211 40914000.0 42152.0 44896.0 47457.0 48679.0 61909.0 46004.0 43171.0 47867.0 27332.0 48486.0 True False 39809.360587825526 48339.37883660695 44403.66828727478 42048.836224041144 54131.43794651783 52340.63341726729 45178.53704171365 48006.28504519156 32799.16371988738 47086.083198242915 0.8454591650832208 1.02661711387391 0.9430316830628156 0.8930204716116684 1.149627114207236 1.1115945490072203 0.9594881114129186 1.0195429686320348 0.6965787233097215 1.0 15.523013098247834 -8.215248889706514 24.998505668839393 0.8482887315639102 0.9976174479088397 0.21610723943848664 0.11044356638442744 532.960506348607 288441.3797524998 0.07368464171886736 0.027849925879984243 6.0918767798205556e-09 8.215248889706514 0.1493287163449295 ESADPLGAWLQDAR ddPTM_A459_Selumetinib_30min_R1 1 ESADPLGAWLQDAR 14 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 115.92 0.037765 1839100.0 1016.0 1069.8 1382.1 965.33 1019.6 1196.2 1070.1 1218.3 620.0 920.16 False True 1039.6708232081417 944.5473186634728 1194.4184113318709 796.7532369883477 927.3773600250006 1184.1673140627004 989.3814954575469 1185.9867264038785 1052.094716991639 1038.2714991174087 1.001347743910839 0.9097305661056796 1.1503912149637125 0.7673842898178698 0.893193505565091 1.140517981153592 0.9529121200943865 1.142270328533564 1.0133136832572027 1.0 10.019968030105451 -6.749108471405373 24.99667664609929 1.052639061476142 0.9440915594817895 0.200087551499326 0.10528717378866644 374.708768574312 759592.2692862127 0.034493238077956304 0.034258480816010205 1.7819336478449445e-07 6.749108471405373 -0.10854750199435259 ESADPLGAWLQDAR ddPTM_A459_Selumetinib_30min_R2 1 ESADPLGAWLQDAR 14 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 229.0 4.3716e-12 1474100.0 10240.0 5278.2 7692.1 9203.3 9059.5 6757.4 6584.0 7278.1 4708.9 8815.7 False True 9670.901793967854 5683.020967912036 7197.198660525245 7949.794663421967 7921.364617042405 7688.170512430265 6890.169045948497 7299.278066045687 5650.8115776590685 8561.167835060633 1.1296241330957812 0.6638137550157942 0.8406795426963233 0.9285876432494521 0.9252668292054695 0.8980282434067963 0.804816489840454 0.8526030801724134 0.6600514890640556 1.0 13.063591893780437 -7.2607397161342675 23.84957933343202 0.8170846865630319 0.8871067380340968 0.05405217362288495 0.13177843860188712 107.52256280759113 3665308.7877591574 0.050654332589375475 0.03683618182736571 5.486056599114615e-08 7.2607397161342675 0.07002205147106488 ESAFT(ph)SPISVTKPVVLASGAALSSPK ddPTM_A459_Selumetinib_30min_R1 1 ESAFTSPISVTKPVVLASGAALSSPK 26 1 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 ES(0.009)AFT(0.599)S(0.17)PIS(0.17)VT(0.051)KPVVLAS(0.002)GAALSSPK 61.091 0.006809899999999999 7086900.0 957.51 1418.9 1389.4 1599.2 1212.0 987.14 1216.5 1161.6 695.08 1029.1 True False 979.8181200098695 1252.7745283712854 1200.7271114279017 1319.9297407019008 1102.37481399598 977.2102678514079 1124.7384255902311 1130.7905945914354 1179.4999933654005 1161.19500928287 0.8438015253053706 1.078866614441422 1.0340443266023387 1.1366994605988379 0.9493451187641463 0.8415556905079301 0.9686042538925881 0.973816271643975 1.0157639190111878 1.0 10.181394561172363 ESAS(ph)PTIPNLDLLEAHTK ddPTM_A459_Selumetinib_30min_R1 2 ESASPTIPNLDLLEAHTK 18 0 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 ES(0.141)AS(0.845)PT(0.013)IPNLDLLEAHTK;ES(0.079)AS(0.889)PT(0.032)IPNLDLLEAHTK 147.02 0.00015215 44215000.0 6533.8 11942.2 8772.2 11475.3 8970.8 9732.099999999999 8741.099999999999 7334.700000000001 4640.299999999999 7536.8 True False 6686.0248274383475 10544.001672221837 7580.983422245458 9471.354273059354 8159.392723923375 9634.203910039798 8081.751789500015 7140.159929536675 7874.2501858972555 8504.221694648846 0.7862006739129846 1.239854986242479 0.8914376523151647 1.1137238201373634 0.9594520247581917 1.132873090091475 0.9503223316232849 0.8396018102432011 0.9259224969231469 1.0 13.053963491314919 -7.511880272827813 24.296717995768848 0.9086496911610782 1.027428782928291 0.1118829804641992 0.12585964152744183 644.567676029608 1423926.8723706445 0.05073260706964508 0.031846985264783495 3.0769449561719365e-08 7.511880272827813 0.11877909176721291 ESAS(ph)PTIPNLDLLEAHTK ddPTM_A459_Selumetinib_30min_R2 2 ESASPTIPNLDLLEAHTK 18 0 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 ES(0.147)AS(0.726)PT(0.128)IPNLDLLEAHTK;ES(0.246)AS(0.754)PT(0.001)IPNLDLLEAHTK 147.75 0.00014003 27337000.0 80693.0 75385.0 83064.0 79110.0 79338.0 61202.0 64701.0 68476.0 58938.0 88907.0 True False 76208.40609967269 81166.7870990203 77719.75267324518 68335.08152763825 69370.85114928082 69632.0199635595 67709.72470259931 68675.25382318799 70727.2468653126 86340.02390187242 0.8826544475628757 0.9400829815760574 0.9001590358786049 0.7914647047735679 0.8034611066140369 0.806485993595485 0.7842217507323497 0.7954046190818653 0.8191710364326036 1.0 16.397741871736216 -5.693060180194095 6.257551595362765 0.8163557337006301 0.9126322381783225 0.2418527452635133 0.061499574286695106 0.22573938844157504 15.663638322333707 0.015490083495809026 0.026900619980868103 2.027401762957238e-06 5.693060180194095 0.09627650447769243 ESAWS(ph)PPPIEIR ddPTM_A459_Selumetinib_30min_R1 1 ESAWSPPPIEIR 12 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 ES(0.214)AWS(0.786)PPPIEIR 96.756 0.016828 4001800.0 1636.9 2252.8 1662.7 2357.1 1945.6 1694.0 1770.5 1600.8 1012.5 1414.9 True False 1675.0365851470556 1989.0411287016932 1436.9144725573417 1945.4767332469032 1769.6208235235795 1676.9598980289363 1636.9497595622724 1558.3415838687756 1718.138549925861 1596.516197293102 1.0491823308696053 1.24586341940916 0.9000312524192579 1.218576257820287 1.1084264766771403 1.0503870244925964 1.0253261209236246 0.976088802926615 1.0761798426091573 1.0 10.640711474360508 -6.930442470669105 3.1633734609628212 1.0186731030575304 1.107120815856785 0.1626879252106178 0.09136315186599851 0.45689959267404295 9.258975762562674 0.03360609670740813 0.028543948526191923 1.173701147901314e-07 6.930442470669105 0.08844771279925445 ESAWS(ph)PPPIEIR ddPTM_A459_Selumetinib_30min_R2 1 ESAWSPPPIEIR 12 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 ESAWS(1)PPPIEIR 109.83 0.007472499999999998 4502800.0 29209.0 37713.0 34549.0 41412.0 40965.0 31736.0 37018.0 37912.0 30164.0 35807.0 True False 27585.68071289133 40605.46583359228 32326.154954107005 35771.61416031537 35818.61046825345 36107.34592927559 38739.41034977545 38022.31764333052 36197.64285257876 34773.158872241154 0.7933038472070633 1.1677243929083176 0.929629518930834 1.0287133904556272 1.0300649014906398 1.0383683018829644 1.1140607182714277 1.0934387003213308 1.0409650439170988 1.0 15.085686510242072 -4.743931577216695 24.999760690325513 1.0488490685822844 0.7933030699774779 0.6086273653255454 0.06156459099690174 750.4063921282115 1071464.5780103083 0.01503164261941066 0.45143140587923075 1.8033018273862453e-05 4.743931577216695 -0.25554599860480653 ESCS(ph)SPSTVGSSLTTR ddPTM_A459_Selumetinib_30min_R1 2 ESCSSPSTVGSSLTTR 16 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;H0YEP9 Q7Z589 EMSY;C11orf30 Protein EMSY 1 ES(0.001)CS(0.883)S(0.111)PS(0.002)T(0.002)VGSSLTTR;ES(0.001)CS(0.603)S(0.369)PS(0.013)T(0.013)VGSSLTTR 296.44 9.524099999999997e-76 26423000.0 5838.4 7222.8 5806.799999999999 6041.0 6172.0 5202.9 5652.6 6005.200000000001 3106.3999999999996 5169.5 True False 5974.423360451196 6377.151218211379 5018.268454469223 4986.052753614419 5613.743689755101 5150.563549855229 5226.2198310656295 5845.922588361299 5271.333917520687 5833.055680194143 1.0242356130316157 1.0932779606175689 0.8603155412194178 0.8547925867644841 0.9624018691980422 0.8829957799552158 0.8959660455172758 1.0022058606796511 0.9037002570401041 1.0 12.510036130313262 -5.255862191345799 24.993643219960994 0.9173391409947186 1.058756795749786 0.5272949991079334 0.052378731005045205 335.4166258017759 1503126.3578826596 0.013345292680713577 0.033252546093130594 5.5480173258087514e-06 5.255862191345799 0.1414176547550675 ESCSS(ph)PSTVGSSLTTR ddPTM_A459_Selumetinib_30min_R2 1 ESCSSPSTVGSSLTTR 16 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;H0YEP9 Q7Z589 EMSY;C11orf30 Protein EMSY 1 ES(0.001)CS(0.143)S(0.484)PS(0.182)T(0.182)VGS(0.003)S(0.005)LTTR 188.0 8.9058e-07 20247000.0 23528.0 21934.0 26278.0 25479.0 32206.0 17656.0 20087.0 21118.0 16386.0 18900.0 True False 22220.407950046472 23616.267271073986 24587.302089323097 22008.716246273434 28159.99435470694 20087.95373478982 21021.085301635398 21179.449883726906 19663.65786309361 18354.307891902634 1.2106372019535232 1.2866879759324932 1.339592984607732 1.1991035769854888 1.5342444139302185 1.0944544383311787 1.1452943595279486 1.1539225564081683 1.0713374744993038 1.0 14.16383109356493 ESDES(ph)GESAPDEGGEGAR ddPTM_A459_Selumetinib_30min_R1 1 ESDESGESAPDEGGEGAR 18 0 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 ES(0.11)DES(0.876)GES(0.014)APDEGGEGAR 89.50200000000002 0.014323 0.0 0.0 0.0 163.74 0.0 169.84 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 141.505007359439 0.0 154.4780019876874 0.0 0.0 0.0 0.0 0.0 0.0 ESDFSDTLS(ph)PSKEK ddPTM_A459_Selumetinib_30min_R2 1 ESDFSDTLSPSKEK 14 1 A0A590UJP6;H7C5G9;H7BZW9;H7BZK0;A0A590UJS6;A0A590UJU9;H7C3M8;A0A5F9VB99;A0A590UJK3;Q14BN4-4;Q14BN4-6;Q14BN4-2;Q14BN4-3;Q14BN4 A0A590UJP6 SLMAP Sarcolemmal membrane-associated protein 1 ESDFSDT(0.001)LS(0.934)PS(0.065)KEK 68.329 0.035032 4434500.0 30949.0 18744.0 17803.0 29080.0 14738.0 19447.0 43212.0 30031.0 22272.0 17115.0 True False 29228.978478663194 20181.604528540647 16657.57436244079 25119.253834201936 12886.480680608298 22125.647727710566 45221.443622953615 30118.385238100305 26727.022331674674 16620.845479889613 1.7585735042196733 1.2142345317486631 1.0022098083154445 1.5113102317565597 0.775320406907115 1.331198689891046 2.7207667430438054 1.8120850274760112 1.608042284251606 1.0 14.020706151466333 -7.029686743799337 24.808539391508283 1.8776238386298751 1.2309608223233315 0.22099034502900583 0.4663977944272378 782.1981088673168 653662.8805012607 0.17224096616329 0.13364271828397972 9.339276990765465e-08 7.029686743799337 -0.6466630163065437 ESDQTLAALLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 6 ESDQTLAALLSPK 13 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQT(0.006)LAALLS(0.994)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK 244.0 3.2120999999999996e-18 1060042200.0 28220.38 35781.299999999996 31358.600000000002 33124.2 25873.63 29139.26 30192.899999999998 29122.3 19721.34 30697.96 True False 28877.859946699402 31592.0087617249 27100.274360459905 27339.68028824281 23533.364734860384 28846.1455007312 27915.425244556765 28349.882001437814 33465.67359031592 34638.3421894521 0.8336963642415065 0.9120531400993303 0.7823779271027684 0.789289514455116 0.6794021667130088 0.8327807763708532 0.8059111227631857 0.8184537772154344 0.966145360169885 1.0 15.080082263069928 -8.294807092639664 3.2010473150431062 0.9989326459215676 0.8039387875261149 0.629913439571414 0.054434526324009636 0.16961436309385247 3.3213541652852774 0.05421820404473182 0.015207415576489263 5.0721595627511615e-09 8.294807092639664 -0.1949938583954527 ESDQTLAALLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 8 ESDQTLAALLSPK 13 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK;ESDQTLAALLS(1)PK 187.08 0.00013811 291619900.0 630007.7 565299.1 547539.4000000001 534300.3999999999 495951.6 415870.9 533548.0 505976.2 347512.3 499843.6 True False 594994.3941546442 608655.7232469042 512311.3111198247 461527.7638003997 433645.72614444135 473153.3415748418 558359.039205305 507448.50697313034 417024.47030494025 485411.8165183607 1.225751771809491 1.2538955635907594 1.0554158215479836 0.9507963096381327 0.8933563448347548 0.9747462370581678 1.1502790418456679 1.0453979275017014 0.8591147889560417 1.0 18.888849703290383 -5.3717443591059695 3.472184979367762 0.987505864584478 1.2419651094754034 0.6395809161082708 0.07610826448603528 0.1606000955342863 3.5374964853862085 0.022262634426868915 0.052658942672392635 4.24869583423743e-06 5.3717443591059695 0.2544592448909254 ESDSAEGDEAES(ph)PEQQVR ddPTM_A459_Selumetinib_30min_R1 1 ESDSAEGDEAESPEQQVR 18 0 Q8TEH3;Q8TEH3-7;Q8TEH3-6 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 ESDSAEGDEAES(1)PEQQVR 250.1 1.589099999999999e-79 0.0 520.73 701.27 358.04 558.64 517.2 399.49 381.05 309.43 314.88 474.27 True False 532.8619958358029 619.1649823884219 309.4201345729421 461.0840109715542 470.41935131907627 395.47149330789824 352.30709171488485 301.2229112297071 534.3283620747209 535.1471742810089 0.9957298131149132 1.156999442667887 0.5781963344731478 0.8616022528588301 0.8790466883266328 0.7389957610058011 0.6583368251700538 0.5628786354602578 0.9984699308047582 1.0 9.063791900738767 -5.248396108912384 24.995194878431533 0.7690514059781864 1.076364653500122 0.3666666781910828 0.15222767729763914 759.9504009785749 1456308.7801208564 0.03763282976822702 0.09823332959937013 5.6442194512496355e-06 5.248396108912384 0.30731324752193545 ESDSAEGDEAES(ph)PEQQVR ddPTM_A459_Selumetinib_30min_R2 2 ESDSAEGDEAESPEQQVR 18 0 Q8TEH3;Q8TEH3-7;Q8TEH3-6 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 ESDSAEGDEAES(1)PEQQVR;ESDSAEGDEAES(1)PEQQVR 289.61 1.0383999999999997e-80 7833700.0 14379.400000000001 12271.400000000001 14777.1 14312.2 14985.8 10759.1 10776.6 13112.0 8991.5 9297.2 True False 13580.25051329897 13212.57692122992 13826.35747408998 12362.85367007789 13103.149829248194 12241.068363614468 11277.733253427788 13150.153749191544 10790.05124350093 9028.765678973396 1.5041093097504215 1.4633868450036285 1.5313674056565048 1.3692739527916946 1.4512670164608892 1.355785364119265 1.2490891506567605 1.4564730348264798 1.1950749002855725 1.0 13.140313055254008 -13.023504824070004 0.10519105649882822 7.007502735283466e-10 1.6975779960262791 0.8041066340417452 0.06964517582613 48.180799383795396 0.4769763646501971 11.58069768802678 1.071124371265133 9.473166618117812e-14 13.023504824070004 1.6975779953255288 ESDTKNEVNGTSEDIKSEGDT(ph)QSN ddPTM_A459_Selumetinib_30min_R2 1 ESDTKNEVNGTSEDIKSEGDTQSN 24 2 O95232 O95232 LUC7L3 Luc7-like protein 3 1 ESDTKNEVNGTSEDIKS(0.205)EGDT(0.638)QS(0.156)N 73.753 0.0018432 30018000.0 106240.0 132360.0 114320.0 111010.0 97064.0 77816.0 84380.0 74127.0 50954.0 107680.0 True False 100335.60611241641 142511.58639552095 106964.77566220475 95890.2464970687 84869.95255683019 88534.44765668362 88303.83719579807 74342.69729761459 61146.22377371364 104570.99861376054 0.9594974461610736 1.3628213202964268 1.0228914046932436 0.9169870018287313 0.8116012439577307 0.8466443739692214 0.8444390736092495 0.7109303562472798 0.5847340523117791 1.0 16.67412326906681 -5.810324205985554 1.8669706162535256 0.7889159119737583 1.165926481538538 0.5216313179114449 0.13687802069877872 0.24890416470917112 1.7716062266942674 0.04204784387461576 0.08131591236412257 1.5476608403778153e-06 5.810324205985554 0.37701056956477963 ESDTKNEVNGTSEDIKSEGDTQS(ph)N ddPTM_A459_Selumetinib_30min_R1 5 ESDTKNEVNGTSEDIKSEGDTQSN 24 2 O95232 O95232 LUC7L3 Luc7-like protein 3 1 ESDTKNEVNGTSEDIKS(0.052)EGDT(0.372)QS(0.575)N;ESDTKNEVNGTSEDIKS(0.022)EGDT(0.068)QS(0.911)N;ESDTKNEVNGTSEDIKSEGDT(0.003)QS(0.997)N;ESDTKNEVNGTSEDIKSEGDT(0.01)QS(0.99)N;ESDTKNEVNGTSEDIKSEGDT(0.004)QS(0.996)N 142.01 3.2453e-08 185255000.0 13183.7 15098.099999999999 17897.7 18320.2 14362.600000000002 14855.199999999999 14452.3 14183.4 8195.7 11801.2 True False 13490.854558985418 13330.40743308374 15467.290645028892 15120.920982745713 13063.505365922983 14705.770175442422 13362.15137538651 13807.21015782383 13907.504309755443 13315.998973422411 1.0131312405409465 1.0010820412114845 1.161556911794622 1.135545370116487 0.9810383278037658 1.1043685272726345 1.0034659361311318 1.036888797106536 1.0444206504907085 1.0 13.70087304391779 -7.27604863380633 24.79891334876915 1.0242679139370108 1.0667904522411575 0.13320877109993523 0.05590835415374332 1821.0398788965997 3091165.9397694096 0.02459050492225319 0.016680336829264085 5.2960413365826616e-08 7.27604863380633 0.04252253830414676 ESDTKNEVNGTSEDIKSEGDTQS(ph)N ddPTM_A459_Selumetinib_30min_R2 4 ESDTKNEVNGTSEDIKSEGDTQSN 24 2 O95232 O95232 LUC7L3 Luc7-like protein 3 1 ESDTKNEVNGTSEDIKS(0.037)EGDT(0.046)QS(0.916)N;ESDTKNEVNGTSEDIKSEGDT(0.027)QS(0.973)N;ESDTKNEVNGTSEDIKS(0.017)EGDT(0.04)QS(0.943)N;ESDTKNEVNGTSEDIKSEGDT(0.005)QS(0.995)N 138.42 6.8031e-08 85997800.0 217382.0 227861.0 229697.0 224403.0 195396.0 130414.0 130494.0 141006.0 95638.0 202278.0 True False 205300.77868909365 245337.20601140618 214918.5450951837 193838.92428323298 170848.60761759666 148377.34471957866 136562.2295689556 141416.30411520012 114768.27234898979 196437.70855863873 1.0451189855322978 1.2489313167597373 1.094079882483603 0.9867704408971458 0.8697342728705092 0.7553404374765778 0.6951935581563269 0.7199040609506289 0.5842476640106512 1.0 17.58371237317629 -6.216318414025217 1.323527867911007 0.7250163977220235 1.1528920235824653 0.6939081341935296 0.10980847780869644 0.21808463562243105 0.7736845865475322 0.04036193922073332 0.05972869946954639 6.076892950736567e-07 6.216318414025217 0.4278756258604418 ESEAGTGS(ph)SEHEDGER ddPTM_A459_Selumetinib_30min_R2 1 ESEAGTGSSEHEDGER 16 0 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 ESEAGT(0.002)GS(0.549)S(0.449)EHEDGER 77.899 0.017897999999999997 827020.0 4009.4 3694.4 4020.4 5088.3 4677.2 2794.9 2666.9 4771.6 4851.0 4398.2 True False 3786.573598899876 3977.748600631697 3761.731841080549 4395.264762192906 4089.608321301477 3179.872105423881 2790.9161343620967 4785.484566019094 5821.335548264808 4271.212538104029 0.8865336400657594 0.9312925931795005 0.8807175497640687 1.0290437956393395 0.9574818122061506 0.7444893170395616 0.6534247849911424 1.1204042232333744 1.36292340789224 1.0 12.06042997380102 -7.95045518591676 9.707280664963681 1.2015106203521044 0.8770038072864906 0.5195079491650214 0.12917579112908786 0.2752162279016021 51.65710663578358 0.07302551165874982 0.034974461391191314 1.120843077994151e-08 7.95045518591676 -0.3245068130656138 ESEAGTGSS(ph)EHEDGER ddPTM_A459_Selumetinib_30min_R2 1 ESEAGTGSSEHEDGER 16 0 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 ESEAGTGS(0.157)S(0.843)EHEDGER 114.99 0.0013467000000000002 1146600.0 3882.7 2089.5 3514.7 3558.6 4124.0 3939.0 3776.9 4240.4 4615.1 3696.0 True False 3666.915077679592 2249.7579311985537 3288.5680285160192 3073.912541072594 3605.906250972226 4481.561495318138 3952.5333337853676 4252.7388619639905 5538.248956668091 3589.2868766387387 1.0216277504999962 0.6267980266056041 0.9162176614859122 0.8564131669383926 1.0046302719466802 1.2485938431076282 1.1012029602623457 1.184842284310959 1.5429942345133743 1.0 11.80948152098519 -6.530921656816041 1.793541634845648 1.2284967957305715 0.8332890958613995 0.5257559780628949 0.1604907283250571 0.26671351700290385 1.736779654943898 0.05965116057166901 0.06462344384228007 2.9449528313675806e-07 6.530921656816041 -0.3952076998691719 ESEAGTGSSEHEDGEREGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ESEAGTGSSEHEDGEREGSPR 21 1 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 ESEAGTGS(0.002)S(0.005)EHEDGEREGS(0.994)PR 50.493 0.025752 768710.0 341.06 300.22 394.54 574.13 629.71 458.64 489.05 275.03 51.928 354.23 True False 349.0060344127648 265.0701028315086 340.9636350530906 473.8689732548661 572.7528416843306 454.02649801180155 452.1605647635862 267.73531097665506 88.11802332893838 399.6988709923924 0.8731724299001273 0.6631745097837761 0.8530512838490862 1.1855649531316423 1.4329608694222007 1.1359213922334126 1.131253044675706 0.6698425499974728 0.2204610263475464 1.0 8.64276968743682 -7.859765674324189 5.18779241947397 0.5617445836045641 1.0413774927495545 0.3282105315801207 0.2663161293939799 0.23823802615229564 10.088151536709068 0.16179025539141434 0.07581494307531789 1.3811292585342336e-08 7.859765674324189 0.47963290914499035 ESEDDLNKES(ph)EEEVGPTK ddPTM_A459_Selumetinib_30min_R1 1 ESEDDLNKESEEEVGPTK 18 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.001)EDDLNKES(0.999)EEEVGPTK 57.595 0.032801 3492700.0 1496.8 1986.2 1512.9 1554.0 1810.1 1316.0 1923.9 2006.6 509.13 1737.8 True False 1531.6725277342002 1753.6547806406713 1307.4564897648427 1282.6230721928177 1646.3767745991115 1302.7622348323969 1778.778674059224 1953.3784496446046 863.9564246160528 1960.8635576054526 0.7811214206074759 0.8943277944245043 0.6667758624478028 0.6541113313152285 0.8396182223966756 0.6643818891831978 0.9071404622519553 0.9961827492117868 0.44059996998010936 1.0 10.937273436911003 -7.268563082690619 24.795462674887194 0.8356626809323884 0.7525383078850768 0.06205111859743262 0.1634857363546309 1726.3273214547676 6008796.5539579345 0.06569138628706299 0.04532840481412782 5.388115755494356e-08 7.268563082690619 -0.08312437304731157 ESEDDPES(ph)EPDDHEK ddPTM_A459_Selumetinib_30min_R2 1 ESEDDPESEPDDHEK 15 0 P16383-3;P16383-4;P16383 P16383-3 GCFC2 GC-rich sequence DNA-binding factor 2 1 ESEDDPES(1)EPDDHEK 145.04 0.00021879 0.0 35887.0 39274.0 35481.0 34506.0 37737.0 23209.0 25951.0 27584.0 25315.0 30795.0 True False 33892.544207043415 42286.189514186146 33198.19108879189 29806.223273829874 32996.140686939565 26405.829079674706 27157.772920930955 27664.26487322299 30378.707360198652 29905.86833498103 1.1333074775628285 1.4139763153014286 1.1100895221276628 0.996668043206938 1.1033333096148166 0.8829648008845036 0.9081084895021886 0.9250446956881694 1.0158109110867897 1.0 14.868140987286253 -5.565747606538771 3.0937652913554214 0.9706175700794367 1.2753504636217505 0.6463117586719498 0.08740996240751724 0.1415259384922445 2.7528182744989844 0.024332892449706673 0.04950743095827438 2.718018406499276e-06 5.565747606538771 0.3047328935423138 ESEDKPEIEDVGS(ph)DEEEEK ddPTM_A459_Selumetinib_30min_R1 9 ESEDKPEIEDVGSDEEEEK 19 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK 198.45 1.4020999999999996e-15 1425973000.0 30769.670000000002 37504.759999999995 16654.41 14000.75 16609.07 22071.690000000002 30861.489999999998 35202.78 23119.66 47865.8 True False 31486.543443644547 33113.68526371011 14392.832598125771 11555.78183912714 15106.78255106947 21849.6688380911 28533.58296257185 34269.0879196552 39232.37442684338 54009.84168237486 0.5829778881562545 0.6131046533786854 0.26648536914379833 0.21395696560425506 0.27970425538202043 0.40454976644046237 0.5283033994132826 0.6344971000135017 0.7263930647596428 1.0 15.72093469891161 -8.23851824321713 0.9765231006856335 0.9836082752314863 0.38506689627997037 0.705142462889397 0.12472222767226157 0.31816537665984296 0.6235699011639719 0.1342932546674821 0.04720678650631269 5.774066173389385e-09 8.23851824321713 -0.5985413789515159 ESEDKPEIEDVGS(ph)DEEEEK ddPTM_A459_Selumetinib_30min_R2 7 ESEDKPEIEDVGSDEEEEK 19 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK;ESEDKPEIEDVGS(1)DEEEEK 137.04 9.1644e-05 3007681900.0 674387.0 373948.0 454273.0 515643.0 454745.0 553999.0 1025778.0 915109.0 594921.0 376805.0 True False 636907.270325059 402628.60916766454 425045.56975504616 445411.53386621096 397615.86762811954 630307.3335477932 1073478.7095405462 917771.815685549 713921.8234816004 365925.66059303563 1.7405373246928306 1.1003016528415812 1.1615626219440258 1.21721863709792 1.0866028553005147 1.7225010471424407 2.933597790875934 2.50808269143565 1.9510023492875206 1.0 18.4811910628721 -7.001132418586191 6.513193368580938 2.2401368803862445 1.2564736709218916 0.37461391394616406 0.49735337529411866 0.12538633386271641 26.192105258969224 0.17582751921074635 0.14706001867915594 9.973959063940656e-08 7.001132418586191 -0.9836632094643529 ESEDKPEIEDVGS(ph)DEEEEKK ddPTM_A459_Selumetinib_30min_R1 6 ESEDKPEIEDVGSDEEEEKK 20 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK 151.18 1.3565e-05 2376813000.0 18727.7 24111.0 12076.669999999998 10987.58 10245.17 15945.039999999999 17520.699999999997 21365.4 14639.86 28710.999999999996 True False 19164.018972239282 21288.072911100197 10436.724546399877 9068.805415421075 9318.49618243167 15784.647374537957 16199.099493003503 20798.72018740001 24842.77316693098 32396.33651882272 0.5915489537252065 0.6571135874802242 0.3221575544610112 0.27993305385477685 0.28764043048563515 0.48723556644643623 0.5000287450277472 0.6420084004040292 0.7668389650322648 1.0 14.98354305732126 -8.26900769093539 1.094755874075835 0.9907504495282689 0.42798915016857586 0.7080380771158272 0.11728912508983509 0.2896329622909517 0.7069784243533285 0.12543383200919994 0.04188827736537491 5.382602503632538e-09 8.26900769093539 -0.562761299359693 ESEDKPEIEDVGS(ph)DEEEEKK ddPTM_A459_Selumetinib_30min_R2 4 ESEDKPEIEDVGSDEEEEKK 20 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK;ESEDKPEIEDVGS(1)DEEEEKK 112.37 0.00037183 706219400.0 373133.0 191637.0 241113.0 218562.0 203325.0 190256.0 491675.0 380835.0 256323.0 173389.2 True False 352395.7616297472 206334.94168992474 225600.05208398562 188793.47855952036 177781.49575143715 216462.03702798896 514538.86173552903 381943.1667993715 307594.7622630138 168383.00327675545 2.0928226410746884 1.2253905541213754 1.3398029949209769 1.1212145815526173 1.05581615894589 1.285533770128868 3.055764843971986 2.2683000027716997 1.8267565982146605 1.0 17.361386993328743 ESEDKPEIEDVGS(ph)DEEEEKKDGDK ddPTM_A459_Selumetinib_30min_R1 3 ESEDKPEIEDVGSDEEEEKKDGDK 24 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK 68.411 0.0014238 2192794600.0 7758.51 13303.0 6447.650000000001 6262.360000000001 4562.57 7616.54 7076.669999999999 9306.84 7736.540000000001 13939.8 True False 7939.268187567524 11745.478575603081 5572.094544406299 5168.756385056251 4149.886349087156 7539.924522865008 6542.871084440295 9059.992370323129 13128.343325474985 15729.109115150473 0.5047500229952835 0.7467351449860368 0.35425366456636687 0.32861087981630444 0.2638347994604433 0.4793611938010182 0.41597213399315286 0.5760016224692873 0.834652695798874 1.0 13.941149339460567 -8.290588586500613 1.856937613761572 0.9959258437829313 0.4392957464530789 0.7045577021148616 0.12360473356857696 0.1995095786492197 1.3016616758556117 0.12800030285694627 0.037511090885055484 5.121667888743522e-09 8.290588586500613 -0.5566300973298524 ESEDKPEIEDVGS(ph)DEEEEKKDGDK ddPTM_A459_Selumetinib_30min_R2 8 ESEDKPEIEDVGSDEEEEKKDGDK 24 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK;ES(0.001)EDKPEIEDVGS(0.999)DEEEEKKDGDK;ESEDKPEIEDVGS(1)DEEEEKKDGDK 68.411 0.0014238 7834258100.0 1514834.0 1270695.3 1029259.4 858230.9 669168.7 756765.4 1494024.4 1208652.0 596327.4 814657.1 True False 1430645.590640967 1368153.5435806308 963037.9707769012 741338.3708891186 585101.7454619202 861002.9646176778 1563499.4949531849 1212168.977216889 715609.5427796996 791135.8327896552 1.8083438157469258 1.729353528023539 1.2172852383402926 0.9370557370345067 0.7395717918612912 1.0883124350235298 1.9762718741231424 1.532188186878873 0.9045343582231139 1.0 19.5935658915977 -5.248335424549564 4.804540694987954 1.1931015362063655 1.7828587294278406 0.3329932707970039 0.3364801591954338 0.24271532185320432 16.29454079256001 0.09834998124316857 0.25297743464696915 5.6450081782688025e-06 5.248335424549564 0.5897571932214751 ESEDSETQPFDTHLEAYGPCLS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 ESEDSETQPFDTHLEAYGPCLSPPR 25 0 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSET(0.002)QPFDT(0.022)HLEAYGPCLS(0.976)PPR 195.23 6.1732e-28 222104000.0 5836.4400000000005 7805.3 8098.900000000001 9926.5 7817.0 7502.500000000001 7697.199999999999 5872.15 3372.5699999999997 5611.22 True False 5972.4176962646925 6891.451847414477 6999.113864073289 8193.023118482626 7109.953730203439 7427.031661724966 7116.594006948724 5716.401506568608 5723.004967233051 6331.474744911307 0.9432901396416066 1.0884433919527565 1.1054476478325326 1.2940149725887276 1.1229538167103652 1.1730334497020893 1.1240025892338001 0.9028546644939172 0.9038976222455452 1.0 12.628325860045049 -7.756338120572498 24.791919114358915 0.9275320855672635 1.1283635397293272 0.49956161856680537 0.08501421559662967 89.57109282245148 435319.3094985517 0.04340041664900895 0.024061403859092688 1.7525155471520203e-08 7.756338120572498 0.20083145416206372 ESEDSETQPFDTHLEAYGPCLS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 5 ESEDSETQPFDTHLEAYGPCLSPPR 25 0 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSETQPFDTHLEAYGPCLS(1)PPR;ESEDSETQPFDTHLEAYGPCLS(1)PPR 165.94 3.7656999999999997e-16 129479200.0 99314.7 101913.7 120774.1 115964.6 115978.5 90225.66 84183.18 99267.5 89894.9 112292.5 True False 93795.18656224411 109730.15308580504 113003.62589489784 100170.02142990702 101408.24396905475 102653.42567800624 88097.86467580653 99556.3519903806 107876.3918733682 109050.32375404653 0.8601091985182084 1.006234088156325 1.0362520899045438 0.918566932967863 0.9299215305199109 0.941339944203486 0.8078643111092779 0.9129395361990968 0.989234952815674 1.0 16.73463452756691 ESEEGNPVRGSEEDS(ph)PKK ddPTM_A459_Selumetinib_30min_R1 1 ESEEGNPVRGSEEDSPKK 18 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ESEEGNPVRGSEEDS(1)PKK 93.551 0.005167199999999999 8792400.0 1161.9 1200.5 1556.2 1694.4 1022.0 1195.4 1025.8 910.68 736.18 768.97 True False 1188.9700093361619 1059.9449019026915 1344.8765875947172 1398.5048478272267 929.5602804487551 1183.375361336358 948.4230801236819 886.5258080944631 1249.2436915401674 867.6747899020966 1.3702945195288183 1.2215923687517642 1.549977714284479 1.6117845811620573 1.0713233705379885 1.363846656729399 1.093062851613675 1.021725902851797 1.4397602720267175 1.0 9.761010602363646 -6.2725349035204 24.988545070567476 1.1723896270242584 1.4308941220157723 0.3972654376633932 0.1647572645410704 808.6031385311468 1821074.506931156 0.05146353775258231 0.05888721761890948 5.339063626893765e-07 6.2725349035204 0.25850449499151384 ESEGFEEHVPSDNS(ph) ddPTM_A459_Selumetinib_30min_R2 1 ESEGFEEHVPSDNS 14 0 P62699 P62699 YPEL5 Protein yippee-like 5 1 ESEGFEEHVPS(0.018)DNS(0.982) 81.904 0.030951 5106400.0 18939.0 18345.0 24904.0 24475.0 26126.0 16272.0 22376.0 20980.0 17804.0 19457.0 True False 17886.44619882396 19752.002511527855 23301.70375342501 21141.462778270045 22843.81831059658 18513.320297490933 23416.52833720285 21041.048326574026 21365.29748532398 18895.225854642835 0.9466119291942201 1.045343552041983 1.2332058866446118 1.1188785432313462 1.208973022409442 0.9797882512709917 1.2392827964768183 1.1135642668914663 1.1307246417525203 1.0 14.205734142784836 -4.983884781626449 4.678435919329754 1.1340275159583422 0.9609460292429709 0.31605080417945586 0.08329548679808792 0.19404497781825325 11.204212033961314 0.01968540289401448 0.07846608495461357 1.0378037087362183e-05 4.983884781626449 -0.17308148671537127 ESEKS(ph)LENETLNK ddPTM_A459_Selumetinib_30min_R1 1 ESEKSLENETLNK 13 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 ES(0.001)EKS(0.52)LENET(0.479)LNK 160.63 0.0017275 19700000.0 2375.7 2735.8 1907.4 1913.9 1700.2 2233.2 2287.4 2222.2 1442.8 2510.7 True False 2431.049187692501 2415.491264161085 1648.3855565982294 1579.67329335253 1546.41721019469 2210.7360355833653 2114.859576403694 2163.260037277106 2448.326222057317 2832.972801288989 0.8581265540517669 0.8526348234130762 0.5818571769726211 0.5576027036453672 0.545863768791242 0.7803590753068618 0.7465160185941224 0.7636007081652295 0.8642251069065472 1.0 11.468101035466042 -8.389281958853955 0.9774341778727164 0.9981065721377128 0.6874105971958272 0.44922745000869213 0.10641214196013386 0.5493941788781099 1.142444908302995 0.1136138862300943 0.03889275520035889 4.080543774362665e-09 8.389281958853955 -0.3106959749418856 ESEKS(ph)LENETLNK ddPTM_A459_Selumetinib_30min_R2 2 ESEKSLENETLNK 13 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 ESEKS(0.797)LENET(0.203)LNK;ESEKS(0.847)LENET(0.153)LNK 155.26 0.0017356 26145000.0 75040.0 59231.0 69432.0 64983.0 59982.0 59664.0 85537.0 78896.0 52118.0 52760.0 True False 70869.57720892064 63773.82724231705 64964.82071184576 56132.203298072425 52446.524914116395 67882.17442413347 89514.63998835011 79125.5742980641 62543.05629859108 51236.68171305731 1.3831804644534587 1.2446908174005487 1.2679357550059673 1.095547202147705 1.02361283284961 1.3248745265022532 1.747081133974723 1.5443149644466436 1.2206695322084533 1.0 15.64488942370804 -6.998517297956108 24.99822294512019 1.4394619678904703 1.2000780958033341 0.11309190907660704 0.20707698673849886 75.10422743978705 1266222.9902418628 0.07323993479832312 0.0641072641597046 1.0034198821220674e-07 6.998517297956108 -0.23938387208713618 ESENSGDSGYPS(ph)EK ddPTM_A459_Selumetinib_30min_R1 2 ESENSGDSGYPSEK 14 0 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 ESENSGDS(0.001)GYPS(0.999)EK;ESENSGDSGYPS(1)EK 205.12 1.5849e-05 13780000.0 4408.9 3426.6000000000004 4045.0 4144.799999999999 4246.8 4543.5 4315.8 6436.700000000001 2449.3 5648.3 True False 4511.6187917739935 3025.4120790168786 3495.7112175945426 3420.98848753204 3862.677689833436 4497.796515167929 3990.2557313294874 6265.977806651765 4156.28321020584 6373.314324101086 0.7078920891619962 0.4746999638125636 0.5484918897496225 0.5367675770509793 0.6060704828610883 0.7057233154434626 0.6260880176959241 0.9831584459841528 0.6521384320381933 1.0 12.637828099129278 -7.833650719255557 0.5255509697616237 0.9736612039202758 0.5417949771504991 0.5649112037668541 0.11129342194936127 0.565734347308408 0.35993176379360176 0.10630631895068883 0.06653429404185188 1.4667269799040376e-08 7.833650719255557 -0.4318662267697767 ESENSGDSGYPS(ph)EK ddPTM_A459_Selumetinib_30min_R2 4 ESENSGDSGYPSEK 14 0 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 ESENSGDSGYPS(1)EK;ESENSGDSGYPS(1)EK;ESENSGDSGYPS(1)EK;ESENSGDSGYPS(1)EK 204.9 1.8356e-05 39234100.0 189316.0 163329.0 239364.0 207304.0 165823.0 122976.0 112525.0 137397.0 104434.0 164370.0 True False 178794.574611994 175855.80911449122 223963.5808398178 179068.83758065314 144990.832263571 139914.82773501996 117757.63546405734 137796.80252270217 125323.71812976438 159624.2110154518 1.120096841666998 1.101686316854955 1.4030677390044415 1.121815020675774 0.9083260699690209 0.8765263542726364 0.7377178857451535 0.86325753246394 0.7851172283484797 1.0 17.284319963483632 -6.265537059314541 2.9067009405788817 0.841460478606968 1.205524994032843 0.7217752492460153 0.09989982747386164 0.1373853826609579 2.344094168960607 0.032330662208063264 0.040349977859802405 5.425789498843895e-07 6.265537059314541 0.3640645154258749 ESEPES(ph)PMDVDNSK ddPTM_A459_Selumetinib_30min_R1 1 ESEPESPMDVDNSK 14 0 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 ESEPES(1)PMDVDNSK 191.01 0.00010454 4087000.0 1440.1 1905.4 1508.8 1347.0 1518.3 1356.3 2031.1 1971.5 1227.0 1804.8 True False 1473.6515280531946 1682.3148822035714 1303.9132472451543 1111.7717363215725 1380.9700330776361 1342.6568534218693 1877.8924917520078 1919.209415665473 2082.1293834657104 2036.4636602407188 0.7236326170823999 0.8260961956005218 0.6402830910771204 0.5459325192133093 0.6781216183913635 0.6593080346266338 0.9221340544471257 0.9424226187461721 1.0224240304978454 1.0 10.9918503550023 -7.3517361979921345 3.3610059155096628 0.9804271175897783 0.6766807815884921 0.8133517276364313 0.06908905091496124 0.12081281632317815 2.606073763261292 0.0353805314172154 0.02287766124527233 4.4490143035893576e-08 7.3517361979921345 -0.3037463360012862 ESEPES(ph)PMDVDNSK ddPTM_A459_Selumetinib_30min_R2 2 ESEPESPMDVDNSK 14 0 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 ES(0.006)EPES(0.994)PMDVDNSK;ESEPES(1)PMDVDNSK 218.21 1.079e-08 10465800.0 74880.0 58421.0 69533.0 78450.0 78098.0 49229.0 60669.0 73919.0 67792.0 67676.0 True False 70718.46936839004 62901.702846877546 65059.322481806164 67764.97466620166 68286.63103502146 56009.847893632046 63490.22871334287 74134.09205205075 81352.29426674248 65722.01803663517 1.0760240096244416 0.9570872095226062 0.9899166888871306 1.031084812831336 1.0390221279717355 0.8522234947565166 0.9660419842548316 1.1279947613709376 1.2378240458379501 1.0 16.004089159392322 -7.7745616992597695 12.385691446767149 1.137255838877504 0.9847479053342378 0.37876404998923197 0.07820956544142633 0.5971119686040217 554.340607825913 0.04107663592073529 0.020464162300574133 1.680499163936905e-08 7.7745616992597695 -0.1525079335432662 ESEPESPMDVDNS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 ESEPESPMDVDNSK 14 0 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 ESEPES(0.36)PMDVDNS(0.64)K 217.39 1.1915e-08 7829400.0 49834.0 47116.0 53954.0 59152.0 57277.0 46540.0 51137.0 58320.0 44659.0 52719.0 True False 47064.425781308055 50729.64569818186 50482.658380673514 51095.39555710847 50081.35119712322 52950.4625519437 53514.971826043184 58489.70154460428 53592.04787671781 51196.865489588075 0.9192833454008931 0.9908740547504568 0.9860497883594103 0.9980180440441175 0.9782112775499563 1.0342520395650445 1.045278286361624 1.1424469249294051 1.0467837701434444 1.0 15.643767863972823 -6.957619026442087 1.830184745484026 1.071768522558342 0.9752968207167542 0.5045143724719454 0.039180047887457346 0.26648976764297777 1.8104809917008267 0.017258744995645225 0.013645634617896694 1.1025060302528744e-07 6.957619026442087 -0.09647170184158782 ESEQES(ph)EEEILAQK ddPTM_A459_Selumetinib_30min_R2 1 ESEQESEEEILAQK 14 0 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 ES(0.444)EQES(0.556)EEEILAQK 152.71 0.00037742 6976700.0 54059.0 38327.0 44578.0 57132.0 51418.0 46006.0 54434.0 60247.0 50824.0 36390.0 True False 51054.6171953231 41266.55765927111 41709.90001285662 49350.52304180281 44958.41115724775 52342.908899113085 56965.28885892471 60422.30879557222 60990.22014121021 35339.326147425236 1.444696964009396 1.167723388021583 1.1802686853409494 1.3964760628407853 1.2721920890538356 1.4811518669245112 1.6119517565581851 1.7097753517853789 1.72584558875789 1.0 15.108986910298162 -6.881194233725079 3.2983206676801062 1.5697353843972521 1.2834474849330344 0.1872628338956922 0.20836896205849456 0.31348893642257214 6.730155315708111 0.07483367676331265 0.06535760384861482 1.3146367429774796e-07 6.881194233725079 -0.28628789946421773 ESEQES(ph)EEEILAQKK ddPTM_A459_Selumetinib_30min_R1 1 ESEQESEEEILAQKK 15 1 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 ES(0.003)EQES(0.997)EEEILAQKK 105.96 0.0023631 16801000.0 3326.9 2755.2 2986.4 3267.4 2826.8 2447.2 3434.4 2772.7 1794.5 2777.0 True False 3404.410296979496 2432.6199031422702 2580.863283120975 2696.8099266942145 2571.116439112077 2422.583389879818 3175.3404429486964 2699.1589890010937 3045.1354349056382 3133.4550002706533 1.0864717370076924 0.7763379090914507 0.8236477890692709 0.8606506002036974 0.8205372149560137 0.773134890933671 1.0133671754259834 0.8614002718302809 0.9718139991295913 1.0 11.613538559309715 -8.016253148138858 1.003552407682043 0.9919900559134827 0.8570082397358617 0.17296379433614872 0.09509131053982245 0.8772971611563422 1.6555972061219646 0.08561699858613317 0.03145548098012202 9.632673760858339e-09 8.016253148138858 -0.13498181617762095 ESEQES(ph)EEEILAQKK ddPTM_A459_Selumetinib_30min_R2 2 ESEQESEEEILAQKK 15 1 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 ES(0.366)EQES(0.634)EEEILAQKK;ES(0.042)EQES(0.958)EEEILAQKK 88.574 0.008977200000000001 24281000.0 87962.0 79540.0 96591.0 96395.0 91542.0 59642.0 67259.0 66721.0 54278.0 83010.0 True False 83073.42417978514 85640.4622385895 90376.44022032921 83265.83470934985 80041.67556413655 67857.14412382942 70386.67677118017 66915.14706374388 65135.11665403366 80613.28561411829 1.0305177806229497 1.0623616391041972 1.1211109872502336 1.0329046146056973 0.9929092326949935 0.8417613003475595 0.8731399078324247 0.8300759180571673 0.8079948132349312 1.0 16.298730003787604 -6.560737302584262 2.402908706699987 0.8589102807109481 1.0667637884183965 0.7294007628917909 0.05478365379506056 0.1397265619282736 1.6323326757512169 0.01898921325677196 0.019886262398891234 2.7495568107891787e-07 6.560737302584262 0.20785350770744837 ESES(ph)ESDETPPAAPQLIK ddPTM_A459_Selumetinib_30min_R1 1 ESESESDETPPAAPQLIK 18 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 ES(0.076)ES(0.914)ES(0.01)DETPPAAPQLIK 203.99 6.822e-11 4826100.0 618.91 944.53 866.39 695.29 614.96 554.34 655.48 734.03 345.3 876.64 True False 633.3293988107783 833.9439884999155 748.7389967396138 573.8706537097446 559.3369765800061 548.7638429004493 606.0366158700245 714.561139934531 585.948880285827 989.1652831967102 0.6402665050718641 0.8430785053483052 0.756940229766147 0.5801564849255045 0.565463614707931 0.5547746693323036 0.6126747735337827 0.7223880094388936 0.592367009072742 1.0 9.950067796022124 -10.557620409617307 4.944061981105432 1.0000058430305678 0.6541119323724348 0.5770248176452168 0.08936478106815733 6.400381320440768e-06 1.2496415840779985e-06 0.09622001881218754 0.023336388517656875 2.769361117956561e-11 10.557620409617307 -0.345893910658133 ESES(ph)ESDETPPAAPQLIK ddPTM_A459_Selumetinib_30min_R2 1 ESESESDETPPAAPQLIK 18 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 ESES(0.951)ES(0.049)DETPPAAPQLIK 214.28 3.4574e-12 3099100.0 18782.0 14815.0 18435.0 20656.0 22156.0 15744.0 17182.0 20159.0 15870.0 18680.0 True False 17738.171630303157 15951.26286226685 17248.912170510364 17842.6171664125 19372.56520284689 17912.593090197715 17980.99704548709 20217.659352497903 19044.443444848996 18140.659863531288 0.9778129221177194 0.8793099579764545 0.9508425989060282 0.9835704599854191 1.0679085186858135 0.9874278678367119 0.9911986212604552 1.114494153167056 1.0498208768653785 1.0 14.146939314166158 -5.907048981788147 2.5043557369404117 1.0362574660388597 0.927619156882212 0.5171048785285859 0.042939537175505076 0.22241019158255448 2.828966452659964 0.01336464004667473 0.021772076912594383 1.2386568770640662e-06 5.907048981788147 -0.10863830915664774 ESESCDCLQGFQLTHSLGGGTGSGMGTLLISK ddPTM_A459_Selumetinib_30min_R1 1 ESESCDCLQGFQLTHSLGGGTGSGMGTLLISK 32 0 Q9BVA1;Q13885 Q9BVA1 TUBB2B;TUBB2A Tubulin beta-2B chain;Tubulin beta-2A chain 0 145.52 3.1604e-20 10031000.0 786.36 694.37 949.69 942.83 903.35 729.31 787.43 655.98 406.95 512.72 False True 804.6806580097978 613.0728375961451 820.7273142737613 778.1824396110387 821.6421519993961 721.973803560498 728.0335211364695 638.5812794766608 690.5644275479797 578.5326063157253 1.3908994051938632 1.0597031712704712 1.4186362277839566 1.3450969420146348 1.4202175348972423 1.2479396937680847 1.2584139825286813 1.1037947948056792 1.1936482404089679 1.0 9.176254462235148 -8.053860483635201 0.873418831812556 1.026343061036004 1.3170868865270584 0.4643565857984966 0.10587389042975796 0.522825519560363 0.7828960155416953 0.09916479325496623 0.03844667941928796 8.83363633908949e-09 8.053860483635201 0.2907438254910544 ESESEAKVDGET(ph)ASDSESR ddPTM_A459_Selumetinib_30min_R2 1 ESESEAKVDGETASDSESR 19 1 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 ESESEAKVDGET(0.688)AS(0.253)DS(0.057)ES(0.002)R 64.89 0.034425 14228000.0 57309.0 14213.0 40573.0 35459.0 19471.0 22599.0 90548.0 47957.0 50027.0 23846.0 True False 54123.99520610391 15303.091398001932 37962.577352542285 30629.42302981317 17024.878907051454 25711.807116703407 94758.6614174581 48096.546930291246 60033.797871169525 23157.504020651322 2.337211953319209 0.6608264597235951 1.6393207713010929 1.3226564919301564 0.7351776293278007 1.1103013128605836 4.091920326687822 2.0769313863618404 2.592412283190485 1.0 14.499192143624398 ESGADGASTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ESGADGASTSPR 12 0 O75528;O75528-2 O75528 TADA3 Transcriptional adapter 3 1 ESGADGAS(0.023)T(0.225)S(0.752)PR 112.02 0.0065517 7250600.0 2286.3 2995.4 2781.5 3142.6 3076.3 2762.7 2481.1 2537.4 1659.9 2103.8 True False 2339.5663416346197 2644.697175476318 2403.78757768584 2593.8039039080727 2798.0492081648795 2734.9097463308995 2293.94862945493 2470.0999093632126 2816.7290657006797 2373.843222747352 0.9855605960898033 1.1140993432647566 1.0126142934173354 1.0926601550822512 1.1787000848887466 1.152102093400115 0.966343778507851 1.0405488811112213 1.1865691207866529 1.0 11.213008941952905 -4.75007166043398 24.63161838458274 1.0835588282155626 0.9855603365535432 0.13785786100682573 0.07278815006981985 908.7366999179785 1968903.4052909925 0.018473978806193704 0.277671633393785 1.7779860105905874e-05 4.75007166043398 -0.09799849166201935 ESGADGASTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ESGADGASTSPR 12 0 O75528;O75528-2 O75528 TADA3 Transcriptional adapter 3 1 ESGADGAS(0.004)T(0.031)S(0.965)PR;ESGADGAS(0.026)T(0.083)S(0.891)PR 127.52 0.0025814 136019000.0 104642.0 90447.0 89433.0 107644.0 113431.0 80969.0 95137.0 99101.0 94276.0 114047.0 True False 98826.4165551157 97383.99406705705 83678.97814728778 92982.70150374253 99180.78369399377 92121.7447865992 99561.05901038919 99389.36750294622 113133.83429153013 110754.16678030783 0.8923042755686833 0.8792806347433241 0.7555379682759346 0.8395413392272923 0.8955038584754013 0.8317677561453021 0.8989373664638612 0.8973871628694129 1.0214860314550749 1.0 16.75700145114221 -8.035687260715342 1.5290181411693853 1.0151836705530346 0.8488814758110274 0.6837289409686846 0.041202465060253025 0.23737418357721501 0.9932591242757695 0.03820166490472184 0.012541089058995088 9.211126343133572e-09 8.035687260715342 -0.16630219474200725 ESGLSSS(ph)SYELSQYIR ddPTM_A459_Selumetinib_30min_R1 1 ESGLSSSSYELSQYIR 16 0 U3KQ39;Q96JE7-2;Q96JE7;E9PK14 U3KQ39 SEC16B Protein transport protein Sec16B 1 ESGLSS(0.393)S(0.591)S(0.016)YELSQYIR 149.6 0.00025436 9639600.0 1613.4 1773.2 2193.2 1977.8 2058.9 1582.3 1782.3 1871.1 1035.6 1370.2 True False 1650.989080870095 1565.5929196616844 1895.3754863852546 1632.4143579040885 1872.672858528318 1566.3834986134514 1647.8596760620376 1821.4723498106362 1757.337562768613 1546.0785168782315 1.0678559095457156 1.0126218704745056 1.2259244700018903 1.0558418217984054 1.2112404629420312 1.0131332151074828 1.06583181777166 1.1781240926162448 1.1366418610595184 1.0 10.594397872381814 ESGLSSS(ph)SYELSQYIR ddPTM_A459_Selumetinib_30min_R2 3 ESGLSSSSYELSQYIR 16 0 U3KQ39;Q96JE7-2;Q96JE7;E9PK14 U3KQ39 SEC16B Protein transport protein Sec16B 1 ESGLS(0.184)S(0.184)S(0.616)S(0.015)YELS(0.001)QYIR;ES(0.002)GLS(0.046)S(0.15)S(0.698)S(0.104)YELSQYIR;ESGLS(0.195)S(0.023)S(0.66)S(0.121)YELS(0.001)QYIR 189.04 3.9404e-14 1934200.0 52159.0 45320.8 42094.2 51287.0 52398.0 50160.0 40991.8 47015.7 42494.5 46405.0 True False 49260.21158902044 48796.75963065965 39385.90500069961 44301.62212499021 45815.294795936585 57069.08469285553 42897.999923710755 47152.50790313189 50994.58739553472 45065.167075330246 1.093088404768983 1.0828043652671193 0.8739766777045946 0.9830568707519999 1.0166453997463814 1.2663679821148721 0.9519103713074692 1.0463182755832787 1.1315743556501843 1.0 15.459725118923483 -6.5505817809487175 24.999879096727447 1.0816530223956449 1.0034536934215317 0.1139958900752368 0.09637007333612314 468.16957417348783 422483.98314642475 0.03238574502879726 0.032386299884044796 2.814609952800892e-07 6.5505817809487175 -0.07819932897411319 ESGNS(ph)QELAR ddPTM_A459_Selumetinib_30min_R1 1 ESGNSQELAR 10 0 Q86W50 Q86W50 METTL16 Methyltransferase-like protein 16 1 ES(0.001)GNS(0.999)QELAR 92.151 0.027029 6056900.0 1196.0 1187.1 1581.6 1510.4 1491.0 1163.2 1368.1 1348.5 648.18 817.91 True False 1223.8644729891118 1048.113780132182 1366.82740710693 1246.6369937194536 1356.1393132574308 1151.4992641010977 1264.9031155363705 1312.7333994546748 1099.9141188058713 922.8967156180654 1.3261120689648223 1.135678307653591 1.4810188225575853 1.3507871169360255 1.4694377933171234 1.247701118244783 1.3705792794909482 1.4224055381706882 1.191806298789629 1.0 9.850025389971576 -8.541908337206873 4.034867507284499 1.0003935047423638 1.3480369122201317 0.5629808517986088 0.09718991252189398 0.14046609602571447 7.300155524434976 0.09354082502123777 0.02450562717912249 2.871386556885679e-09 8.541908337206873 0.3476434074777679 ESGNS(ph)QELAR ddPTM_A459_Selumetinib_30min_R2 1 ESGNSQELAR 10 0 Q86W50 Q86W50 METTL16 Methyltransferase-like protein 16 1 ES(0.004)GNS(0.996)QELAR 94.547 0.023718 13766000.0 39755.0 28808.0 40572.0 33431.0 45094.0 27274.0 32293.0 30578.0 20768.0 28178.0 True False 37545.57625187423 31017.48096768025 37961.64169145358 28877.64012830831 39428.88857452511 31030.74593127876 33794.68848736555 30666.976917539607 24922.180306403538 27364.427924763615 1.3720577808205199 1.13349641560059 1.3872623902763905 1.055298514103973 1.4408811572064213 1.1339811676895057 1.2349861133688393 1.1206876680139668 0.9107510076558206 1.0 14.74001407571723 -8.000800847027577 2.444673197219468 0.9548439859330734 1.2490010883279903 0.49554750287564175 0.11866860716919626 0.2379605343532671 2.6728417385931618 0.08627517998543573 0.02988550633546326 9.98157680729927e-09 8.000800847027577 0.2941571023949169 ESGVAGDPWKEET(ph)DTDLEVVLEK ddPTM_A459_Selumetinib_30min_R1 1 ESGVAGDPWKEETDTDLEVVLEK 23 1 Q1ED39 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 ES(0.006)GVAGDPWKEET(0.497)DT(0.497)DLEVVLEK 65.801 0.0058386 9301100.0 953.99 1179.7 1295.1 1067.5 915.01 906.88 937.8 586.42 586.31 788.07 True False 976.2161108585973 1041.5801755723496 1119.2325334750794 881.0811644567771 832.2475070581364 897.7576105811585 867.0609909728882 570.8662366393844 994.9252476118826 889.2264609518515 1.0978262048270917 1.1713328621118795 1.258658601181327 0.9908400201155108 0.9359230112959939 1.0095938998713274 0.9750733126460983 0.6419807121217627 1.1188659934240917 1.0 9.796407069444188 -5.89742207540701 5.299342041751398 0.9360228177899488 1.1740555295568407 0.42047871914274704 0.12013382685933294 0.1901865513294931 8.263553460192044 0.03380283934090723 0.05096943214807461 1.2664204784277838e-06 5.89742207540701 0.2380327117668919 ESGVAGDPWKEETDT(ph)DLEVVLEK ddPTM_A459_Selumetinib_30min_R1 1 ESGVAGDPWKEETDTDLEVVLEK 23 1 Q1ED39 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 ESGVAGDPWKEET(0.388)DT(0.612)DLEVVLEK 91.889 0.00019058 9191100.0 1255.1 1383.5 1347.6 1374.8 939.38 1268.2 1321.4 1160.1 776.94 957.43 True False 1284.3413880005296 1221.5191768282998 1164.603321836937 1134.7169881922036 854.4132448610088 1255.4430594334692 1221.725734134756 1129.330379464121 1318.4104345475544 1080.3254666579517 1.1888467203996522 1.1306955306784898 1.0780115416881764 1.050347347362379 0.7908850353256828 1.1620970699850794 1.1308867298243317 1.0453612492888544 1.2203826302698686 1.0 10.077250299269734 -5.076866644433008 2.108497456492254 1.0563861076363057 1.1907667182510293 0.13179931736224704 0.10847222496876471 0.8860373096186004 6.556529857483693 0.030837676003711578 0.17921356043293724 8.377864954843712e-06 5.076866644433008 0.13438061061472362 ESGVVAVS(ph)PEKS(ph)ESPQKEDGLSSQLK ddPTM_A459_Selumetinib_30min_R2 1 ESGVVAVSPEKSESPQKEDGLSSQLK 26 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 2 ES(0.001)GVVAVS(0.981)PEKS(0.891)ES(0.124)PQKEDGLS(0.002)S(0.002)QLK 70.699 0.0082584 6038700.0 40156.0 33512.0 31757.0 27915.0 24722.0 20790.0 31699.0 28921.0 14907.0 26107.0 True False 37924.290277204454 36082.26264193632 29713.78919440725 24112.92884393905 21616.201342515837 23653.63378717038 33173.06631037686 29005.155321870698 17888.816536380848 25353.22307586785 1.4958370446123759 1.4231824700931526 1.171992574888435 0.9510794257512231 0.8526017097641109 0.9329635808586719 1.3084358628135226 1.1440421296761631 0.7055835261201207 1.0 14.629881543740346 -5.3734396794438695 2.4232429267317492 0.997529930740839 1.4830485107409592 0.6031756529737429 0.15282119982189152 0.22233587566813526 2.4868307689038196 0.04557773189631009 0.12891322921623624 4.232142872269107e-06 5.3734396794438695 0.48551858000012027 ESGVVAVS(ph)PEKSES(ph)PQKEDGLSSQLK ddPTM_A459_Selumetinib_30min_R2 1 ESGVVAVSPEKSESPQKEDGLSSQLK 26 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 2 ES(0.001)GVVAVS(0.995)PEKS(0.429)ES(0.572)PQKEDGLS(0.002)S(0.002)QLK 58.324 0.021727 9603000.0 61643.0 48498.0 50988.0 44615.0 32867.0 33447.0 38036.0 35466.0 27890.0 38424.0 True False 58217.12883648052 52217.64065435148 47707.48759153693 38538.36003483216 28737.953625291986 38054.02064836399 39804.749366904165 35569.20018828763 33468.77931171004 37314.599282458556 1.5601702806935451 1.3993890235583686 1.278520699911791 1.032795762942814 0.7701530815795624 1.0198158731468152 1.0667339361089219 0.9532247665060299 0.8969352466674774 1.0 15.187452572806546 -5.549803587514448 1.8160884123828387 0.9531892926384967 1.5049811449170658 0.8716113193126511 0.08224374556109827 0.12751235690431215 0.8221253755203288 0.026251661950892423 0.07023815666924392 2.819657851429277e-06 5.549803587514448 0.5517918522785691 ESGVVAVSPEKS(ph)ESPQKEDGLSSQLK ddPTM_A459_Selumetinib_30min_R2 1 ESGVVAVSPEKSESPQKEDGLSSQLK 26 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 ES(0.004)GVVAVS(0.277)PEKS(0.355)ES(0.355)PQKEDGLS(0.005)S(0.005)QLK 43.523 0.028175 15255000.0 15753.0 19310.0 18932.0 21823.0 19520.0 10058.0 20003.0 17409.0 11339.0 16648.0 True False 14877.511324255438 20791.014908563797 17713.93573160305 18850.669753225215 17067.723088985887 11443.398202566605 20933.179135192553 17459.657307784895 13607.116838131238 16167.328983301328 0.920220732789065 1.2859894748253167 1.0956624776980266 1.1659730418484968 1.0556921991637918 0.7078100664856942 1.2947827780837333 1.0799345597419567 0.8416428497363762 1.0 13.980793729304468 -6.520453060270794 24.991404414642638 0.9950406031353521 1.1254284183402852 0.12231610807957027 0.16538716021720612 216.18893454095826 2227389.483328088 0.05385533776504411 0.05474514242605142 3.0168029198094e-07 6.520453060270794 0.13038781520493303 ESHS(ph)PFGLDSFNSTAK ddPTM_A459_Selumetinib_30min_R1 1 ESHSPFGLDSFNSTAK 16 0 Q7LBC6;Q7LBC6-2;Q7LBC6-3 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 ES(0.475)HS(0.525)PFGLDSFNSTAK 81.788 0.013922 6231200.0 2453.9 3157.6 3155.9 3182.1 3024.0 2282.5 2885.3 2697.7 1644.1 2394.9 True False 2511.07109554179 2787.906724071584 2727.3461141178286 2626.405970414904 2750.4797339305615 2259.5401223441827 2667.6594980316436 2626.1482326354294 2789.9176196870203 2702.308743301471 0.9292317547971806 1.031675870117467 1.009265177740486 0.9719118797677296 1.0178258649195793 0.8361517269058056 0.987177910238526 0.9718165028867151 1.0324200099647072 1.0 11.399976799068039 -8.24551899884025 21.924325759154097 1.0162099860858296 0.9706392692196916 0.11082870479217077 0.05295993290088689 336.9152820265068 463981.67390606785 0.036757062072097516 0.013743917156427336 5.681735354431435e-09 8.24551899884025 -0.045570716866138006 ESHS(ph)PFGLDSFNSTAK ddPTM_A459_Selumetinib_30min_R2 2 ESHSPFGLDSFNSTAK 16 0 Q7LBC6;Q7LBC6-2;Q7LBC6-3 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 ES(0.171)HS(0.829)PFGLDSFNSTAK;ES(0.016)HS(0.984)PFGLDSFNSTAK 89.506 0.0086658 6277300.0 46747.0 55321.0 52170.0 60023.0 58336.0 40055.0 45148.0 46009.0 41442.0 47726.0 True False 44148.98888306793 59563.94281494861 48813.438998401216 51847.76385454964 51007.31014954307 45572.21266691245 47247.471459064785 46142.87857280005 49731.55798622763 46348.02637296008 0.9525538051567372 1.2851451825724092 1.0531934759336266 1.1186617405740962 1.1005282024112524 0.9832611274576246 1.0194063298157925 0.9955737532703288 1.0730027118315772 1.0 15.500220285766684 -6.692448960581743 6.7522013040209 1.0144490731130706 1.1112151381823268 0.2280582574948341 0.07994156808669567 0.2944316025450881 23.0528223325981 0.024984803252415533 0.024850186736906654 2.0302571069409764e-07 6.692448960581743 0.09676606506925611 ESHT(ph)PVSIQEEIVGDFK ddPTM_A459_Selumetinib_30min_R1 3 ESHTPVSIQEEIVGDFK 17 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;A0A0A0MR81;F5H176 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 ES(0.17)HT(0.83)PVS(0.001)IQEEIVGDFK;ES(0.216)HT(0.783)PVS(0.002)IQEEIVGDFK;ES(0.237)HT(0.763)PVSIQEEIVGDFK 190.25 1.0106e-07 14133600.0 9807.599999999999 14567.7 10319.4 10632.7 12069.3 10681.4 12162.8 12261.6 5788.0 10112.4 True False 10036.097997732457 12862.10691166 8918.08216040671 8775.898545498436 10977.63394600798 10573.954813935228 11245.35020367354 11936.382536710009 9821.813261205813 11410.42504311737 0.8795551401291672 1.1272241711467414 0.7815731777481847 0.7691123259945476 0.9620705542980238 0.9266924565893634 0.9855329806891462 1.0460944698909258 0.860775407059022 1.0 13.478064913172217 -6.4707460243374815 24.998026016203184 0.9654268587494899 0.894523409863316 0.11229931239474422 0.10169488201590844 881.9825385591736 422917.0783531158 0.032987522026998346 0.037403950226739105 3.382625945353689e-07 6.4707460243374815 -0.07090344888617384 ESHT(ph)PVSIQEEIVGDFK ddPTM_A459_Selumetinib_30min_R2 1 ESHTPVSIQEEIVGDFK 17 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;A0A0A0MR81;F5H176 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 ES(0.15)HT(0.836)PVS(0.014)IQEEIVGDFK 140.63 0.00068249 2934400.0 46854.0 37393.0 49431.0 48240.0 49922.0 40934.0 42898.0 50644.0 35409.0 44939.0 True False 44250.042251422856 40260.92286255445 46250.66327640345 41669.628781358406 43650.352051657464 46572.28693814489 44892.84200077439 50791.365655434485 42491.78941012337 43641.49430445571 1.0139442509168395 0.9225376789731944 1.0597864260500667 0.9548167276459189 1.0002029661757217 1.067156101787971 1.0286733466913145 1.163831955457327 0.9736556936774057 1.0 15.413412880585836 -6.679799539141648 5.142122128190191 1.055710154966088 0.9871928056742185 0.18451211742174412 0.05801306661862076 0.2961280841349277 13.526538921337782 0.0184667791306469 0.018274722503101998 2.0902607269694493e-07 6.679799539141648 -0.06851734929186959 ESIESEIRR ddPTM_A459_Selumetinib_30min_R1 4 ESIESEIRR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ;;; 207.29 0.0020613000000000003 107091900.0 9882.4 10522.5 13637.3 14024.8 13421.1 11518.4 11186.3 9569.1 6187.22 8769.9 False True 10112.64069219699 9290.52080822247 11785.429564326838 11575.63195810156 12207.163874687654 11402.535353870424 10342.508384858205 9315.29638318259 10499.260443330657 9895.602091059987 1.0219328343176897 0.938853515201044 1.1909765020740055 1.1697754064464017 1.2335948598535513 1.1522831303182501 1.0451621123894996 0.9413572107551025 1.06100269056049 1.0 13.272571774386634 -7.465809089844057 5.025931958274781 0.9991200150132026 1.1199504910284712 0.2848057104124677 0.08434861609042658 0.29965268672512013 15.948376402394807 0.041702510841439874 0.02686544344571277 3.421298052359044e-08 7.465809089844057 0.12083047601526864 ESIESEIRR ddPTM_A459_Selumetinib_30min_R2 4 ESIESEIRR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ;;; 196.88 0.00062271 51261700.0 114584.0 104435.0 125510.0 128197.0 136974.0 86259.0 76416.0 89385.0 75973.0 113102.0 False True 108215.87999609495 112444.82868854773 117434.82324495557 110736.34744784019 119766.10155690326 98140.39426876056 79969.49541543133 89645.09555151663 91169.7228629812 109836.45138571264 0.9852455958912335 1.0237478293401454 1.0691789634805273 1.0081930547716567 1.0904039601235902 0.8935138838755903 0.7280779231896565 0.8161688985809452 0.8300497850465007 1.0 16.744997394956755 -6.922693759087935 5.074370067271556 0.8258190291831328 1.0340306505157757 0.6342209916196182 0.0691999697788929 0.11675815421279319 5.396271903544872 0.023719966829460044 0.02076303392188328 1.1948303370258754e-07 6.922693759087935 0.20821162133264293 ESLATSEMSAFHQPGPCEDPSCLTHGDY(ph)YDNLSLASPK ddPTM_A459_Selumetinib_30min_R1 2 ESLATSEMSAFHQPGPCEDPSCLTHGDYYDNLSLASPK 38 0 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 ESLATSEMSAFHQPGPCEDPS(0.003)CLT(0.027)HGDY(0.441)Y(0.441)DNLS(0.084)LAS(0.003)PK;ESLATSEMSAFHQPGPCEDPS(0.009)CLT(0.034)HGDY(0.712)Y(0.242)DNLS(0.003)LASPK 103.31 6.3828e-15 16570800.0 2348.27 2201.02 2395.1099999999997 2274.01 3331.07 2399.91 2901.9 2055.28 455.74 1116.53 True False 2402.9801220619906 1943.3235551735613 2069.8672173974946 1876.896841954433 3029.7753066481746 2375.7690843439336 2683.0073466669064 2000.7672979096806 773.3574940673695 1259.8475014231876 1.9073579297077325 1.5425069724536378 1.6429506071641748 1.4897809773279664 2.4048746401652474 1.8857592539256889 2.129628660322813 1.5881027629530657 0.6138500835964239 1.0 10.299033397549586 -8.133250095060966 4.39133962012214 0.8192711504683952 1.845903697657817 0.6959403337491319 0.27294781712792887 0.13100802416898166 3.9353988824907216 0.2109487580882367 0.07390978727703387 7.357832635246461e-09 8.133250095060966 1.0266325471894218 ESLCDS(ph)PHQNLSR ddPTM_A459_Selumetinib_30min_R1 4 ESLCDSPHQNLSR 13 0 O15042-2;O15042;C9J5L1;E7EW00;E7ET15;U3KPT1;C9JDJ7;H0Y8D9 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 ES(0.002)LCDS(0.998)PHQNLSR;ES(0.019)LCDS(0.981)PHQNLSR;ES(0.002)LCDS(0.998)PHQNLSR;ES(0.079)LCDS(0.921)PHQNLSR 197.73 0.00016469 35294200.0 9992.5 11752.0 8486.5 9640.300000000001 8714.1 8437.1 10874.7 9381.8 4956.65 8284.9 True False 10225.305807979683 10376.070376643427 7334.07991300769 7956.8025758432495 7925.9111935993105 8352.230434273873 10054.412623728807 9132.964187618734 8411.073030607424 9348.347616759931 1.093808898339159 1.1099363012604464 0.7845322204171125 0.8511453469678547 0.8478408718338154 0.8934445718834636 1.0755283217863045 0.9769602674214797 0.8997390100821518 1.0 13.190495666156743 -10.232175163908472 24.686898953240235 0.9999999984163549 0.9452410391631124 0.01984062664520836 0.10774936128509338 0.0 0.0 0.11331050821461797 0.027481834933016917 5.859018051913214e-11 10.232175163908472 -0.05475895925324248 ESLCDS(ph)PHQNLSR ddPTM_A459_Selumetinib_30min_R2 2 ESLCDSPHQNLSR 13 0 O15042-2;O15042;C9J5L1;E7EW00;E7ET15;U3KPT1;C9JDJ7;H0Y8D9 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 ESLCDS(1)PHQNLSR;ES(0.001)LCDS(0.997)PHQNLS(0.002)R 190.18 0.00016181 34244600.0 61952.0 56843.0 67525.0 66526.0 67276.0 54404.0 54731.0 51040.0 49789.0 57923.0 True False 58508.95585350555 61202.675320947266 63180.515015661134 57465.04403624899 58824.18742492901 61897.65716965933 57276.09994741909 51188.51794987311 59748.19122089393 56250.61248797228 1.0401478893410478 1.0880357139939385 1.1231969257076202 1.0215896591088032 1.0457519451456112 1.1003908123292796 1.0182306896598874 0.9100081881031684 1.0621785004326756 1.0 15.779581184831114 -7.515700918778464 24.6307686131554 0.9844798942844385 1.0689389470647748 0.39667814696868975 0.04441884038932816 260.8756145996172 895208.2681400082 0.019520882287351302 0.011847931614934635 3.049994675778557e-08 7.515700918778464 0.08445905278033627 ESLCDS(ph)PHQNLSRPLLENK ddPTM_A459_Selumetinib_30min_R1 2 ESLCDSPHQNLSRPLLENK 19 1 O15042-2;O15042;C9J5L1;E7EW00;E7ET15;U3KPT1;C9JDJ7;H0Y8D9 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 ESLCDS(1)PHQNLSRPLLENK;ES(0.003)LCDS(0.979)PHQNLS(0.019)RPLLENK 116.27 0.00025748 29578000.0 2378.8 2786.8999999999996 3890.9 4073.1000000000004 3394.1 2500.7 2955.0 2729.63 1182.4 2549.75 True False 2434.221411660953 2460.608452405341 3362.5371511838343 3361.8095465563474 3087.104254277026 2475.5452284539315 2732.101970915852 2657.231345312172 2006.4464409208283 2877.0352491682006 0.8460867528003793 0.8552583612302783 1.1687507659685437 1.1684978651298428 1.0730157912279872 0.8604500863066079 0.949624086707227 0.9236005523673797 0.6974007153721616 1.0 11.490367181612985 -6.765999731098365 24.98186461157537 0.8854031688812508 1.0292964268309246 0.22434020313305625 0.1262039495028526 189.21473914494274 1036521.4617821318 0.04742718473987907 0.04321557959248323 1.7139583687378087e-07 6.765999731098365 0.14389325794967378 ESLCDS(ph)PHQNLSRPLLENK ddPTM_A459_Selumetinib_30min_R2 2 ESLCDSPHQNLSRPLLENK 19 1 O15042-2;O15042;C9J5L1;E7EW00;E7ET15;U3KPT1;C9JDJ7;H0Y8D9 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 ESLCDS(1)PHQNLSRPLLENK;ESLCDS(1)PHQNLSRPLLENK 114.27 0.00027268 38208200.0 45374.0 49687.0 54569.0 62862.0 55684.0 39328.0 35391.0 37475.0 24712.8 49604.0 True False 42852.29472651345 53497.83313111393 51058.08995023489 54300.087157001464 48688.47809872386 44745.075015961374 37036.75162593609 37584.04604567979 29656.05053332477 48171.80363333009 0.8895721458281444 1.1105632153266265 1.0599165092275635 1.1272172321036202 1.0107256616199498 0.9288644319101691 0.7688471020900357 0.7802084043138333 0.6156308939365878 1.0 15.555901321413865 -7.016250083977415 2.148278251660596 0.7699807393906271 1.0522255660554185 0.5428264387734272 0.10662052567944574 0.21877366887442584 2.020377764223339 0.044704380274433866 0.03460895657780758 9.632741724355214e-08 7.016250083977415 0.28224482666479145 ESLPPAAEPS(ph)PVSK ddPTM_A459_Selumetinib_30min_R1 2 ESLPPAAEPSPVSK 14 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 1 ESLPPAAEPS(0.975)PVS(0.025)K;ESLPPAAEPS(0.991)PVS(0.009)K 202.32 4.8431e-05 105094000.0 13910.2 18436.8 17838.3 18545.9 15411.3 13586.5 14482.3 13626.0 9079.1 12563.1 True False 14234.28059546249 16278.210884964208 15415.956838768047 15307.20671465943 14017.350636086005 13449.832145554989 13389.888451233384 13264.594216514204 15406.569588772232 14175.696259956867 1.0041327307266812 1.148318261512591 1.087492039619573 1.0798204500119564 0.9888297815523776 0.9487951701919376 0.9445665458462726 0.9357278805404204 1.0868298322878365 1.0 13.791131976524222 -6.275742545669083 4.1572252569530175 0.9760542411894277 1.0865071060947453 0.44670020737033633 0.05179766338660336 0.1792057315210228 7.520910807029883 0.01595865611016946 0.019296630334811077 5.299775270317383e-07 6.275742545669083 0.11045286490531758 ESLPPAAEPS(ph)PVSK ddPTM_A459_Selumetinib_30min_R2 4 ESLPPAAEPSPVSK 14 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 1 ESLPPAAEPS(0.957)PVS(0.043)K;ESLPPAAEPS(0.95)PVS(0.05)K;ESLPPAAEPS(0.95)PVS(0.05)K;ESLPPAAEPS(0.973)PVS(0.027)K 190.18 6.912199999999999e-05 110367000.0 327647.0 333908.0 324057.0 365652.0 352254.0 298336.0 331229.0 327322.0 273177.0 339372.0 True False 309437.6914148621 359517.6699165568 303207.5254265838 315849.5668151179 308000.7033292849 339429.07597543375 346631.8048178119 328274.4528289262 327820.03320311976 329573.4485656504 0.9389035820742785 1.0908575053033789 0.919999856621294 0.9583586547694884 0.9345434368871246 1.0299041911679367 1.0517588911558313 0.9960585546488118 0.994679743255527 1.0 18.330240493761245 -6.782602892995671 24.997174007669262 1.0165638557468861 0.9720669383395464 0.19023433540466939 0.0470194872102849 445.871665261003 526635.2259662708 0.01685985119610711 0.014883528582898094 1.6496701153752468e-07 6.782602892995671 -0.04449691740733974 ESLPS(ph)EDDSDQR ddPTM_A459_Selumetinib_30min_R2 1 ESLPSEDDSDQR 12 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 ESLPS(0.568)EDDS(0.432)DQR 102.9 0.012605 0.0 11991.0 16801.0 17395.0 23558.0 20305.0 15920.0 10814.0 13048.0 20765.0 18004.0 True False 11324.588223776233 18089.582676270347 16275.824638243983 20349.359760183263 17754.104370996858 18112.83549262879 11316.872427534478 13085.96751978731 24918.58022257654 17484.177739990206 0.6477049359818837 1.0346258740492809 0.9308887658478529 1.1638728490868488 1.015438337165223 1.0359558088454286 0.6472636343458276 0.7484462646394168 1.4252074414447413 1.0 14.093762328954684 -4.756371314689123 24.899906772349073 0.9858425900162163 0.6477043847602106 0.21366106865941392 0.20117564600590193 257.8039774995035 1266466.0525510125 0.05046527420534543 0.41072207858167065 1.752381603515191e-05 4.756371314689123 -0.3381382052560057 ESLPVSGEESQLT(ph)PEKSPK ddPTM_A459_Selumetinib_30min_R2 2 ESLPVSGEESQLTPEKSPK 19 1 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 ESLPVSGEES(0.321)QLT(0.579)PEKS(0.1)PK;ESLPVSGEES(0.25)QLT(0.748)PEKS(0.002)PK 102.45 0.0015079000000000002 12030500.0 57023.0 59137.0 50538.0 61346.0 65591.0 52093.0 52255.0 54924.0 41486.0 63778.0 True False 53853.88994115522 63672.61774457467 47286.44010161394 52990.56897224732 57350.872189020214 59268.33789682864 54684.96104131811 55083.819746842324 49784.35921569033 61936.56342485534 0.869500775684682 1.028029555140327 0.7634656733737626 0.855561982164836 0.9259614841014109 0.9569200262254794 0.8829188772745641 0.8893586712099854 0.8037959561009759 1.0 15.918503716267827 -5.235643850495154 24.999107675036566 0.8837381508581003 0.9487651162406003 0.10657017694969773 0.07409675893350842 1729.74961405114 1676338.459217487 0.0184202364865765 0.048703010167627514 5.812408771637695e-06 5.235643850495154 0.06502696538250008 ESLQQMAEVTR ddPTM_A459_Selumetinib_30min_R1 1 ESLQQMAEVTR 11 0 K7ELL7;P14314-2;P14314;K7EKX1;K7EJ70;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 220.82 0.0016259 7533100.0 1107.9 1254.1 1509.4 1740.3 1430.5 1289.4 1106.0 1051.7 561.9 1179.9 False True 1133.711914401871 1107.2693889847274 1304.431770540718 1436.3892744769373 1301.111527575287 1276.4298066815288 1022.573529554292 1023.8054995969463 953.5032604477443 1331.3516581992585 0.8515495567379181 0.8316881435235396 0.9797800322005445 1.0788954711032164 0.9772861434184315 0.9587472992732701 0.7680716986054538 0.7689970514489848 0.7161918900806574 1.0 10.378675974267573 -7.25750502732269 24.599599373946184 0.7940649107574015 0.9500677208463818 0.3081954109014512 0.09580848496567387 307.31739393520047 1921514.7114851258 0.03905846137320223 0.02909327344549125 5.52707009860439e-08 7.25750502732269 0.15600281008898031 ESLS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 ESLSPGK 7 0 E7EUA0;Q0ZGT2-2;Q0ZGT2;E7ETM8;Q0ZGT2-4;H7BXY5 E7EUA0 NEXN Nexilin 1 ESLS(1)PGK 93.598 0.025499 8240600.0 61916.0 47680.0 58621.0 63348.0 61896.0 52502.0 93586.0 136570.0 61156.0 97432.0 True False 58474.95658938615 51336.90268463604 54849.38868171892 54719.89311860468 54120.07112273927 59733.67393429629 97937.93443714087 136967.39608961952 73388.90884141049 94618.8850012622 0.6180051327872454 0.5425650776158609 0.579687539976689 0.578318938316328 0.5719795907763795 0.6313081572827608 1.0350780865345686 1.4475693312999027 0.7756264390605692 1.0 16.529840539631458 -7.2697967969014625 4.0793346732286375 1.1105790118853254 0.5793068365245547 0.6923985994869555 0.15567819926354534 0.10982249382222231 4.401572821447606 0.06218779432842191 0.043367782041254244 5.3728312827361166e-08 7.2697967969014625 -0.5312721753607706 ESLT(ph)PGREENPSSVLAQER ddPTM_A459_Selumetinib_30min_R1 4 ESLTPGREENPSSVLAQER 19 1 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;D6RDA9;Q3MSN4 P04150-3 NR3C1 Glucocorticoid receptor 1 ESLT(0.999)PGREENPSSVLAQER;ES(0.017)LT(0.983)PGREENPSSVLAQER;ES(0.023)LT(0.977)PGREENPSSVLAQER;ES(0.042)LT(0.958)PGREENPSSVLAQER 152.68 0.00016243 19331500.0 3414.65 3733.1 4343.24 4456.849999999999 4354.53 3625.1299999999997 4051.5299999999997 3698.76 1861.71 3170.4700000000003 True False 3494.2047012477183 3296.0269165288923 3753.4518637096007 3678.5448129360057 3960.6635303547123 3588.664483554684 3745.919830194485 3600.6568695342785 3159.185896081457 3577.430707493014 0.976735815994709 0.9213391358287626 1.0492032328810468 1.0282644483459054 1.1071251560677355 1.0031401799168718 1.04709780188015 1.006492414232543 0.8830879349988434 1.0 11.804708107819662 -10.516905666691308 8.21277646381697 0.9999999999492037 1.006768256752727 0.0 0.06121350841262203 4.3555169769144424e-11 5.577475594643271e-11 0.06148052521957029 0.014911217500593286 3.041545609483302e-11 10.516905666691308 0.0067682568035232205 ESLT(ph)PGREENPSSVLAQER ddPTM_A459_Selumetinib_30min_R2 1 ESLTPGREENPSSVLAQER 19 1 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;D6RDA9;Q3MSN4 P04150-3 NR3C1 Glucocorticoid receptor 1 ES(0.107)LT(0.893)PGREENPSSVLAQER 126.09 0.0038954 4413900.0 9497.2 10440.0 10033.0 9812.0 10117.0 9267.7 10790.0 10180.0 7136.0 8276.1 True False 8969.383644303867 11240.714430109067 9387.487703104454 8475.588673355893 8846.012012872447 10544.241551195722 11291.756379979388 10209.622114610273 8563.39939649921 8037.147489109808 1.11599092295584 1.3985950171177068 1.168012372029297 1.0545518400452605 1.1006407465905828 1.3119382922215852 1.4049457715289557 1.2703041879527692 1.0654774480750122 1.0 12.972467841598364 -8.401956328310712 4.1936703185255215 1.0039468633070743 1.230000923842966 0.3217309496704218 0.11498185949595457 0.2786356421550385 7.61269770352284 0.11999394913633295 0.03151718965472418 3.963178850987428e-09 8.401956328310712 0.22605406053589183 ESLTEAEVATEKEGEDGDQPT(ph)TPPKPLK ddPTM_A459_Selumetinib_30min_R1 1 ESLTEAEVATEKEGEDGDQPTTPPKPLK 28 2 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 ESLTEAEVATEKEGEDGDQPT(0.5)T(0.5)PPKPLK 78.531 0.00010174 44419000.0 3440.3 4126.7 3150.1 3138.4 3071.2 3093.9 3559.3 3818.8 2158.4 4026.6 True False 3520.4522963415075 3643.5440455492167 2722.3337222607115 2590.3373550643087 2793.4105022644007 3062.7781750364384 3290.819135391132 3717.5130187894065 3662.647156701212 4543.453332405404 0.7748406418599006 0.8019327544452283 0.5991772167756477 0.5701252253630891 0.6148209958141042 0.674107985921567 0.724299094681996 0.8182130962532136 0.8061372900163865 1.0 12.149573545104937 -8.371784184460656 0.8893386030468203 0.9910274346415213 0.6679991026058062 0.6534894756039895 0.07258833805995432 0.38941200214994465 0.6762498700728652 0.07807702231404019 0.027973231327913437 4.248306241305332e-09 8.371784184460656 -0.3230283320357151 ESMCSTPAFPVS(ph)PETPYVK ddPTM_A459_Selumetinib_30min_R2 2 ESMCSTPAFPVSPETPYVK 19 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 ES(0.013)MCS(0.012)T(0.045)PAFPVS(0.901)PET(0.028)PY(0.001)VK;ESMCST(0.001)PAFPVS(0.99)PET(0.009)PYVK 83.964 0.0027978 11253600.0 92552.0 92379.0 104587.0 127311.0 130762.0 92806.0 102635.0 103404.0 82142.0 102609.0 True False 87408.33035501098 99464.17225469796 97857.98628571584 109971.02217627538 114334.50853288786 105589.18409101183 107407.73086739416 103704.88852054637 98572.6952392431 99646.41155980113 0.8771849280548787 0.998171140312526 0.9820522862179338 1.103612467873749 1.1474021667531091 1.0596386005094047 1.0778885981552402 1.0407287818719857 0.9892247367090218 1.0 16.604530231597273 -4.763417191051176 1.2672300707830024 1.0622446528795175 0.7972743562024006 0.5476609209171808 0.0483393547372587 1.1523410915857204 1.5553801191169083 0.015338194697497066 0.4056819410181941 1.7241808172618982e-05 4.763417191051176 -0.2649702966771169 ESMEAS(ph)PEAMVK ddPTM_A459_Selumetinib_30min_R1 2 ESMEASPEAMVK 12 0 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 ES(0.325)MEAS(0.675)PEAMVK;ES(0.001)MEAS(0.999)PEAMVK 151.7 0.00051553 45543000.0 10388.4 12952.4 11445.900000000001 12650.5 12640.5 11289.8 11878.1 11435.3 6008.2 10458.8 True False 10630.429507692385 11435.926986592605 9891.609647828283 10441.327654295514 11497.16900686154 11176.234862318226 10982.125353886831 11131.998696910676 10195.476578434127 11801.288857339108 0.9007854681127835 0.9690405111540603 0.8381804536270449 0.8847616375225111 0.9742299460547109 0.9470351075567338 0.930586945768822 0.9432866894015388 0.8639290760257646 1.0 13.526656809183239 -6.242276707498396 24.383896677602834 0.9399056053626779 0.898966082934459 0.19703713516032595 0.04418305680191412 1137.832209374109 1447854.6637484974 0.01310361103350193 0.016884126408557066 5.724311944945285e-07 6.242276707498396 -0.040939522428218855 ESMEAS(ph)PEAMVK ddPTM_A459_Selumetinib_30min_R2 2 ESMEASPEAMVK 12 0 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 ES(0.001)MEAS(0.999)PEAMVK;ES(0.002)MEAS(0.998)PEAMVK 174.39 0.00014471 44525000.0 74854.0 75131.0 90784.0 96303.0 95349.0 66739.0 85134.0 86075.0 72947.0 92945.0 True False 70693.91434430379 80893.3061157591 84943.05627814546 83186.36526805889 83370.4061891248 75931.691453678 89092.89968982058 86325.46399951674 87538.43830947686 90261.43634988852 0.7832128226972438 0.8962111549187529 0.9410780474273981 0.9216157933228106 0.9236547695291331 0.8412417808125405 0.9870538658886588 0.9563936437360201 0.969832099393408 1.0 16.46182211620281 -1.522878745280381 0.2554941294274969 0.9775769409431636 3.3724583079768675e-11 0.559232031239784 0.04230400826553542 44.85533029608212 0.6150742549074831 0.0561520598245925 18.980405912988136 0.029999999999997005 1.522878745280381 -0.977576940909439 ESMQMQVEAERR ddPTM_A459_Selumetinib_30min_R1 2 ESMQMQVEAERR 12 1 A0A087WYB4;Q9UJZ1 A0A087WYB4 STOML2 Stomatin-like protein 2, mitochondrial 0 ; 213.63 1.2579e-05 17588500.0 2325.4 3067.3 3588.2 4317.799999999999 3321.3 3586.1 2837.3 2685.2 1635.29 2253.2 False True 2379.5772955592665 2708.1790900509163 3100.9421485717553 3563.7772851442355 3020.8890014231406 3550.0270899182797 2623.280176676665 2613.979773241152 2774.9676931439617 2542.4201680265883 0.9359496614622439 1.0651972966974177 1.2196812264035368 1.4017263275213943 1.188194240831537 1.3963180179906258 1.0318043451932022 1.0281462545469453 1.0914669919794868 1.0 11.311986758843055 ESNLQLTDFS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 ESNLQLTDFSPSR 13 0 Q5BKX5-3;Q5BKX5 Q5BKX5-3 C19orf54 UPF0692 protein C19orf54 1 ESNLQLT(0.077)DFS(0.776)PS(0.147)R;ESNLQLT(0.001)DFS(0.499)PS(0.499)R 118.71 0.0033702 13686300.0 3633.0 4437.6 4262.5 4310.8 4553.299999999999 3312.5 4130.5 3566.0 2103.25 3235.3 True False 3717.6418314125794 3918.0437290157306 3683.6759122365243 3557.999703737962 4141.454818950408 3279.179257509357 3818.93305951537 3471.418095999531 3569.0616346978445 3650.5822694906865 1.0183695522991867 1.0732654244667548 1.0090653052863414 0.9746389592349494 1.1344641794713493 0.8982619799900726 1.0461161473969935 0.9509217543216327 0.9776691418587821 1.0 11.833910877506783 -6.772166012965546 24.99999426894998 0.9759965910251189 1.0381322316150154 0.2872320032443446 0.052866045503532924 301.3931465920248 702436.7103087917 0.0177172183470494 0.01578902804636139 1.6897948689069811e-07 6.772166012965546 0.06213564058989651 ESNLQLTDFSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 ESNLQLTDFSPSR 13 0 Q5BKX5-3;Q5BKX5 Q5BKX5-3 C19orf54 UPF0692 protein C19orf54 1 ESNLQLT(0.04)DFS(0.021)PS(0.939)R 121.45 0.0028395 3370700.0 13782.0 12174.0 15877.0 18766.0 15598.0 14389.0 18400.0 14998.0 15207.0 12127.0 True False 13016.051613717294 13107.706654420288 14855.491105570545 16210.038426844349 13638.439792110747 16370.954139663048 19255.63645890831 15041.64169694744 18248.824919081206 11776.862000270012 1.1052223939975583 1.1130050308919102 1.261413363358588 1.3764310413480854 1.1580707825053953 1.3900947586282073 1.6350396615386025 1.2772198312761562 1.5495490155750156 1.0 13.52366755711011 -5.320381720577277 0.8278346916882467 1.3806037981426122 1.0240084480245246 0.20522499037607977 0.17188831552352346 1.81100128478028 1.6067653986302473 0.06822743076568367 0.5130602682970293 4.782095880486277e-06 5.320381720577277 -0.35659535011808763 ESNRLS(ph)APSYLAR ddPTM_A459_Selumetinib_30min_R1 1 ESNRLSAPSYLAR 13 1 H0YJH0;Q9H4B6 H0YJH0 SAV1 Protein salvador homolog 1 1 ES(0.001)NRLS(0.997)APS(0.002)YLAR 137.93 0.004816300000000001 15475000.0 2715.5 2884.6 3157.2 3208.7 3268.9 2684.1 2949.9 2680.8 1643.4 2221.5 True False 2778.7658665568015 2546.8696909858427 2728.469581258218 2648.360779758745 2973.2285721711696 2657.10039096781 2727.386668021884 2609.6964755343656 2788.7297708129977 2506.6511642424384 1.108557068568654 1.0160447242588535 1.0884919370433492 1.0565334409262066 1.1861357553793253 1.0600200095137053 1.0880599211123803 1.041108756081371 1.1125320549562026 1.0 11.291545523500872 -10.532797052133997 4.680817644398121 0.9999980833066865 1.0826131043501168 0.24392534796620002 0.04437787464631015 8.678942852528933e-07 1.8359371031911882e-07 0.04200285359366015 0.010186951999973624 2.9322631855945e-11 10.532797052133997 0.08261502104343033 ESNYFGLS(ph)PEER ddPTM_A459_Selumetinib_30min_R1 3 ESNYFGLSPEER 12 0 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 ESNYFGLS(1)PEER;ESNYFGLS(1)PEER;ESNYFGLS(1)PEER 253.16 1.1358e-18 60858000.0 5770.2 6861.3 6160.6 6030.5 6561.5 5680.3 6055.599999999999 6059.9 3169.9 5203.6 True False 5904.634433145294 6057.97580626817 5324.024357753511 4977.386381505006 5968.013483526916 5623.161339299743 5598.821216608469 5899.171766670658 5379.088779664185 5871.532747356274 1.00563765667558 1.0317537288701735 0.9067520504165996 0.8477149997581351 1.0164319506204038 0.9576990508707692 0.9535536047430551 1.0047072920315108 0.9161302527157295 1.0 12.519521448706024 ESNYFGLS(ph)PEER ddPTM_A459_Selumetinib_30min_R2 1 ESNYFGLSPEER 12 0 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 ESNYFGLS(1)PEER 79.804 0.041349 12185000.0 25078.0 21674.0 26813.0 29138.0 26433.0 24850.0 24306.0 22092.0 22339.0 28536.0 True False 23684.265155188077 23336.32610710575 25087.880771787077 25169.354134146364 23112.25022598176 28272.86193415988 25436.277161425278 22156.284062472507 26807.424203811093 27712.091534567924 0.854654551268512 0.8420990554969888 0.9053044856066739 0.9082444788676538 0.8340132031229637 1.020235585570741 0.9178764846996912 0.7995168475405354 0.9673547797852662 1.0 14.758227980035945 -14.522878744964803 0.0671359335571029 1.3426919958642778 0.7628799363996215 0.26975663631195834 0.059833708013126374 515.6517677579944 2.4939718138509326 28.286120941422887 3.8098063968805085 3.0000000021796347e-15 14.522878744964803 -0.5798120594646563 ESNYFGLS(ph)PEERR ddPTM_A459_Selumetinib_30min_R1 1 ESNYFGLSPEERR 13 1 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 ESNYFGLS(1)PEERR 76.586 0.023014 3762100.0 1611.3 875.66 2914.7 3022.5 2677.9 1446.0 1661.7 1622.8 972.6 1263.9 True False 1648.840154955984 773.1373201167107 2518.8997493010675 2494.6771143518586 2435.6844178216434 1431.4545528629521 1536.356631157655 1579.7580724027032 1650.43116410656 1426.1338764285476 1.1561608501195957 0.5421211380609445 1.7662435420222413 1.7492587165794369 1.7078932476671143 1.0037308393849596 1.0772878034460112 1.107720739625704 1.1572764600752052 1.0 10.477893703886917 -6.8046379048311225 24.99969317289619 1.0764407584277598 1.3790376693069082 0.17557463947660157 0.3411576526983661 302.21911816671997 174897.05184694187 0.13422177096142413 0.11837323980927213 1.5680579012623897e-07 6.8046379048311225 0.3025969108791484 ESPFSTSAS(ph)PLLSGSQHFDVPPR ddPTM_A459_Selumetinib_30min_R1 2 ESPFSTSASPLLSGSQHFDVPPR 23 0 O14980 O14980 XPO1 Exportin-1 1 ESPFS(0.001)T(0.002)S(0.043)AS(0.953)PLLS(0.001)GS(0.001)QHFDVPPR;ESPFST(0.001)S(0.003)AS(0.991)PLLS(0.005)GSQHFDVPPR 153.83 1.5132e-08 19996000.0 2161.9 2599.2200000000003 2227.6 2281.1 2343.54 2189.1499999999996 2438.37 2143.25 1211.5700000000002 1967.5700000000002 True False 2212.2680636748855 2294.902114055406 1925.1041553309292 1882.7487065502148 2131.567220785591 2167.129138589166 2254.4417877570513 2086.4040477428484 2055.9458004283215 2220.1267752547806 0.9964602419701941 1.0336806616784504 0.867114516516745 0.848036574998809 0.9601105867213252 0.9761285538932646 1.015456330190123 0.9397679767649367 0.9260488289874267 1.0 11.116426345385799 -6.506160537269575 24.63631768590371 0.9702038186341653 0.9340511510976753 0.07976038808642372 0.056166415809253745 1848.8620599322774 2724527.5403417787 0.019604177832858925 0.021673713482302775 3.1177368973606134e-07 6.506160537269575 -0.036152667536489935 ESPFSTSAS(ph)PLLSGSQHFDVPPR ddPTM_A459_Selumetinib_30min_R2 4 ESPFSTSASPLLSGSQHFDVPPR 23 0 O14980 O14980 XPO1 Exportin-1 1 ESPFST(0.003)S(0.047)AS(0.95)PLLSGSQHFDVPPR;ESPFST(0.001)S(0.001)AS(0.999)PLLSGSQHFDVPPR;ESPFS(0.003)T(0.005)S(0.095)AS(0.895)PLLS(0.001)GS(0.001)QHFDVPPR;ESPFSTS(0.002)AS(0.998)PLLSGSQHFDVPPR 180.8 5.4204e-17 25174600.0 64467.2 60442.4 75039.6 95232.0 101866.0 68162.5 65145.0 71753.7 71500.9 81651.8 True False 60884.37110664892 65078.13772705212 70211.63383293914 82261.23731563674 89068.68238640562 77551.26565743162 68174.37158236858 71962.49138753547 85803.07790206703 79294.30037714569 0.767827836516193 0.820716462816652 0.8854562496799031 1.0374167742748153 1.123267144836013 0.9780181587904337 0.8597638324332564 0.9075367465916453 1.0820838003988156 1.0 16.274929549222144 -5.470974354971129 2.797320735208641 0.9924407245956226 0.7925489770598778 0.5544161552855225 0.07380953368686555 0.23106394206965541 3.540051447890267 0.022971153733081277 0.05359385422273328 3.3808479947704045e-06 5.470974354971129 -0.1998917475357448 ESPRPLQLPGAEGPAIS(ph)DGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R1 9 ESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 40 1 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 1 ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR 164.77 3.4274e-51 1533702000.0 8494.009999999998 11639.08 9408.759999999998 10334.07 10126.169999999998 8265.65 10165.69 9013.039999999999 4700.460000000001 7923.210000000001 True False 8691.903906533653 10276.371102738502 8131.102070619241 8529.418669019062 9210.259711420515 8182.505065609728 9398.883818856031 8773.984900720028 7976.337311984708 8940.231182100992 0.9722236181023475 1.1494525022252848 0.9094957283541295 0.9540490055889822 1.0302037524331742 0.9152453553988305 1.0513021002939271 0.9814046999462608 0.8921846817511755 1.0 13.126096422665574 -5.272825950062404 24.999541035469083 0.9690664620389178 1.060838068706204 0.2614699911546936 0.06316355563578885 840.6273762933931 1845623.9786758092 0.015749527419544603 0.03326696616432969 5.335486801717673e-06 5.272825950062404 0.09177160666728623 ESPRPLQLPGAEGPAIS(ph)DGEEGGGEPGAGGGAAGAAGAGR ddPTM_A459_Selumetinib_30min_R2 7 ESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGR 40 1 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 1 ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGR 160.79 3.0318999999999997e-50 1115570000.0 288460.9 256754.0 279353.0 346080.1 299856.5 245950.4 209739.59999999998 249310.0 220686.8 331270.0 True False 272429.3979784749 276446.20620576915 261379.7321165486 298943.3933585273 262185.845718878 279827.835084563 219492.9069911327 250035.4508245074 264830.32650439173 321705.3743571744 0.8468288679442741 0.8593148521629729 0.8124817082674874 0.9292458789532825 0.8149874593881833 0.8698264231479182 0.6822792669526249 0.7772187559008721 0.8232076540019597 1.0 18.29538051205531 ESPRPLQLPGAEGPAIS(ph)DGEEGGGEPGAGGGAAGAAGAGRR ddPTM_A459_Selumetinib_30min_R1 2 ESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRR 41 2 Q6PKG0;A0A0B4J210 Q6PKG0 LARP1 La-related protein 1 1 ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGRR;ESPRPLQLPGAEGPAIS(1)DGEEGGGEPGAGGGAAGAAGAGRR 92.424 1.4783e-12 83050000.0 1000.6099999999999 575.69 4264.7 4241.0 1981.17 1562.41 823.34 790.41 912.9000000000001 492.95000000000005 True False 1023.9222661518688 508.2879471689801 3685.5771643202615 3500.3889634296897 1801.9735233039733 1546.6935739547762 761.2348009251635 769.4457591864809 1549.124624422043 556.2249342396178 1.8408420822622997 0.9138172632692751 6.626055283477351 6.293117672286418 3.23964894843728 2.7806980211506866 1.3685736723863386 1.3833356108681907 2.7850686459062817 1.0 9.11952460849304 -6.9070909538789165 2.5550567005127967 1.6885020787588978 3.9435920118765493 0.2630046962074525 1.6910768506497336 0.44122726589322303 5.846863950551525 0.7493845111126145 0.6353925217673111 1.2385371737086204e-07 6.9070909538789165 2.2550899331176515 ESPSST(ph)TPPIEISSSR ddPTM_A459_Selumetinib_30min_R1 1 ESPSSTTPPIEISSSR 16 0 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 ESPSS(0.002)T(0.499)T(0.499)PPIEISSSR 186.08 1.4674000000000001e-13 0.0 1903.0 2600.8 2019.4 2580.4 2597.9 2693.2 2592.4 2052.8 1081.5 1954.2 True False 1947.3361974065888 2296.2971269208824 1745.176571770191 2129.781580107042 2362.9204036964966 2666.108853229947 2396.8531808467847 1998.3530755658553 1835.2265103652526 2205.0406055199524 0.8831294047518928 1.041385415385315 0.7914487231670164 0.9658695512343346 1.0715994969803815 1.209097395556248 1.0869882281744208 0.9062658848836211 0.8322869455424395 1.0 11.106589507720566 -4.743508553744885 23.64628206622145 0.9920654364530638 0.8831287281651049 0.0679074587182863 0.11779572172812336 1901.1469922221715 2506869.4113865932 0.032327783305545185 0.9182031997174958 1.80505918483131e-05 4.743508553744885 -0.10893670828795887 ESPSST(ph)TPPIEISSSR ddPTM_A459_Selumetinib_30min_R2 1 ESPSSTTPPIEISSSR 16 0 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 ES(0.092)PS(0.103)S(0.14)T(0.588)T(0.077)PPIEISSSR 83.869 0.041697000000000005 5638600.0 41010.0 84034.0 46233.0 59814.0 45556.0 27231.0 44206.0 38057.0 32991.0 41791.0 True False 38730.8283760373 90479.13758810212 43258.41911468435 51667.230015094756 39832.84800419267 30981.823071593888 46261.66659252723 38167.739569324476 39590.12184555851 40584.38524394195 0.954328324631175 2.22940761685205 1.0658882438324369 1.273081499314004 0.9814821085688007 0.7633926911882584 1.1398883170081462 0.9404538060613298 0.9755013315488904 1.0 15.308637139860261 -5.481391817485543 24.68836311082137 1.0148300737958298 1.605813424840354 0.35400928242992 0.31100920717967845 398.8364374902649 237341.73376204248 0.07537503356415892 0.15687675204909576 3.300716183280978e-06 5.481391817485543 0.5909833510445242 ESPSSTT(ph)PPIEISSSR ddPTM_A459_Selumetinib_30min_R1 1 ESPSSTTPPIEISSSR 16 0 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 ESPSST(0.059)T(0.94)PPIEISSSR 135.61 0.00096342 6322800.0 2766.5 3779.2 3484.9 3810.3 3673.0 3047.7 3813.4 3523.0 1708.3 2794.3 True False 2830.9540673280762 3336.729507097586 3011.6697211854703 3144.902633189377 3340.7777985208195 3017.042905090196 3525.752167814046 3429.558595683217 2898.860330704542 3152.9756237869246 0.8978674132367442 1.0582795128273024 0.955183319041415 0.9974395645381325 1.0595634718254918 0.9568874818849806 1.1182300748584262 1.0877212528411808 0.9194046122128994 1.0 11.622498300995526 -6.010918254680425 21.214392638878497 1.0293301371656922 0.9787410677391266 0.10825089323953774 0.06621213780389688 163.00913044734298 316740.6860167828 0.018726326397194976 0.025804627909546473 9.751731729548273e-07 6.010918254680425 -0.0505890694265656 ESPT(ph)QISIGAFPSTK ddPTM_A459_Selumetinib_30min_R1 1 ESPTQISIGAFPSTK 15 0 A0A2R8YH03;Q5VWN6;Q5VWN6-2 A0A2R8YH03 FAM208B Protein FAM208B 1 ES(0.404)PT(0.596)QISIGAFPSTK 152.59 0.00052382 8753900.0 836.73 1353.1 821.89 1184.1 1774.1 1049.7 1218.3 1249.0 719.12 1171.8 True False 856.2241810068388 1194.6784229608757 710.2818523186104 977.3191633098544 1613.6329682427947 1039.1409710513435 1126.4026501410428 1215.8724626762244 1220.2941175532687 1322.2119442985775 0.6475695403440472 0.9035453265358624 0.5371921312474673 0.7391546926527836 1.220404168333855 0.7859110451483625 0.8519077860384858 0.9195745568016591 0.9229186915268903 1.0 10.368737737211454 -6.0299250252589 24.981615649322322 0.9372318844813539 0.7037343718658896 0.433809558063605 0.1362484676572045 674.6048820538391 563163.8299222576 0.039480583100995316 0.051048848454168974 9.334154277340112e-07 6.0299250252589 -0.23349751261546425 ESPVFAPVYFPEELHR ddPTM_A459_Selumetinib_30min_R2 1 ESPVFAPVYFPEELHR 16 0 P09601;B1AHA8 P09601 HMOX1 Heme oxygenase 1 0 83.37 0.026135 1186500.0 9148.5 5246.5 9088.2 10639.0 9490.4 7772.9 7854.2 10960.0 7808.1 6306.3 False True 8640.062994347169 5648.889679843602 8503.475106483993 9189.949846701325 8298.131106747524 8843.546419639086 8219.43586280205 10991.891785474325 9369.938176542251 6124.220733264842 1.4108020221114927 0.9223850553198725 1.3884991212507722 1.500590890982163 1.354969304367931 1.4440280330856987 1.342119466425607 1.7948229275554721 1.529980479907867 1.0 12.58031056701768 -5.49793851142592 22.296140860500707 1.450944779232566 1.1638053222653095 0.1725385797946073 0.2169580489626294 265.6835602010757 237513.64234151167 0.054398848764785256 0.11210143482716098 3.177323892818627e-06 5.49793851142592 -0.2871394569672565 ESQLAHIKDEPPPLS(ph)PAPLTPATPSSLDPFFSR ddPTM_A459_Selumetinib_30min_R1 2 ESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSR 33 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 ESQLAHIKDEPPPLS(0.962)PAPLT(0.035)PAT(0.001)PSSLDPFFSR;ESQLAHIKDEPPPLS(0.972)PAPLT(0.025)PAT(0.002)PSSLDPFFSR 74.282 5.7315e-06 173389000.0 4213.5 5396.4 7614.4 9013.2 7539.2 5608.8 6162.9 5540.7 2387.86 3584.8 True False 4311.666351956209 4764.586979281703 6580.406302905291 7439.21381871834 6857.280691153869 5552.38056438294 5698.027491220745 5393.742637269939 4052.024017605891 4044.9439989089783 1.0659396899238092 1.1779117289551673 1.6268225974649315 1.839138890606367 1.695272095980426 1.372671801112835 1.4086789564349085 1.3334529819757122 1.001750337878305 1.0 11.981904013756012 -8.121751614022575 1.8021418463728494 0.973891276449297 1.4779114509755535 0.3994401509336687 0.21828065016735623 0.4069075602113423 2.355357437099951 0.22418537923245863 0.06980603305998237 7.55524210969427e-09 8.121751614022575 0.5040201745262566 ESQLAHIKDEPPPLS(ph)PAPLTPATPSSLDPFFSR ddPTM_A459_Selumetinib_30min_R2 1 ESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSR 33 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 ESQLAHIKDEPPPLS(0.951)PAPLT(0.049)PATPSSLDPFFSR 67.744 6.0815e-05 15257000.0 31062.0 39126.0 46948.0 46776.0 46717.0 34183.0 20526.0 22394.0 16011.0 52557.0 True False 29335.698391038033 42126.83839008118 43927.41679311747 40405.02810689928 40847.992804720976 38891.39796762124 21480.499671497386 22459.162832473732 19213.647384718166 51039.542850514656 0.5747641290000745 0.8253764833565 0.8606545893597188 0.7916416537122619 0.8003205068736051 0.7619856251755022 0.4208599542987636 0.44003456101188937 0.3764463063666415 1.0 15.639327786821333 -7.237451302366588 15.65418813140387 0.5126737180749139 0.7782883160334426 0.23092159207223995 0.1791937857693567 8.191852756855878 5345.306027950411 0.06488932061419425 0.050058496003020196 5.788268888268755e-08 7.237451302366588 0.2656145979585287 ESQMTPSHGGS(ph)PVGPPQLPIMSSLR ddPTM_A459_Selumetinib_30min_R2 3 ESQMTPSHGGSPVGPPQLPIMSSLR 25 0 A0A5F9ZH11;P55201-3;P55201;P55201-2 A0A5F9ZH11 BRPF1 Peregrin 1 ESQMTPSHGGS(1)PVGPPQLPIMSSLR;ESQMTPSHGGS(1)PVGPPQLPIMSSLR;ESQMTPSHGGS(0.999)PVGPPQLPIMSSLR 93.207 1.3424e-05 4293700.0 27618.3 28670.6 40317.799999999996 35899.7 37355.7 30538.4 24639.3 29172.4 26234.5 31465.6 True False 26083.385450814683 30869.542829490918 37723.796642701556 31010.098929563253 32662.743001804807 34744.787400005975 25785.076271846727 29257.286854249185 31482.133053175225 30557.10637055298 0.8535947459982829 1.0102246742590464 1.234534323546254 1.0148244586223913 1.068908246930114 1.1370444236005457 0.8438323956189476 0.9574626111340047 1.0302720640954952 1.0 14.899220312238986 -7.250420037275783 24.971621440809532 0.9543469800307749 1.0584492830844003 0.17244328978250656 0.10176377399439322 1257.3172684146566 2849290.692653532 0.04031730905236426 0.03092993114149792 5.617977075762724e-08 7.250420037275783 0.10410230305362544 ESRPGLVTVTSSQST(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 ESRPGLVTVTSSQSTPAK 18 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 ESRPGLVTVTS(0.001)S(0.003)QS(0.173)T(0.823)PAK;ESRPGLVTVTS(0.001)S(0.008)QS(0.069)T(0.923)PAK 92.034 0.0071209 11866800.0 3649.7 5108.200000000001 3497.7 3931.6000000000004 3266.7 3921.7999999999997 4129.3 3649.8 2099.32 3825.1000000000004 True False 3734.730908920036 4510.129569262247 3022.7315514908364 3245.0198652723807 2971.227561782727 3882.350252709495 3817.8235764814963 3552.995447778771 3562.3927117336857 4316.088844629196 0.8653044558078125 1.0449575371634228 0.7003404379064689 0.7518426941814186 0.6884074143839807 0.8995065654268375 0.8845562994451042 0.82319794046872 0.825375204258507 1.0 12.075508846982624 -9.568886720980554 11.375344655862932 0.9999999999992253 0.8306845978563421 0.2063103348316785 0.09913764823738229 0.0 0.0 0.10155397692238564 0.02463045726779614 2.6984431879587415e-10 9.568886720980554 -0.1693154021428832 ESRPGLVTVTSSQST(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 ESRPGLVTVTSSQSTPAK 18 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 ESRPGLVTVTSS(0.001)QS(0.046)T(0.953)PAK 88.76799999999999 0.0088279 7237300.0 29289.0 26737.0 35795.0 34275.0 34168.0 34777.0 37916.0 27506.0 29795.0 34570.0 True False 27661.234633156713 28787.641926994827 33491.988670649225 29606.685872327074 29875.51037420441 39567.216075826116 39679.16912912866 27586.03790613656 35754.83254185733 33571.874276353126 0.8239407310255638 0.8574928432658838 0.9976204603577892 0.8818895730579155 0.889897005102503 1.1785822784310824 1.1819170059586843 0.8217008582558412 1.0650234254880968 1.0 15.034965462718894 -6.7191103975570625 24.945721297662207 1.0465805884747548 0.8938622800740947 0.3740349889306177 0.1029357965002909 170.0498917832129 100214.90894262397 0.035683928258325566 0.03568366143687689 1.909367836008479e-07 6.7191103975570625 -0.15271830840066003 ESRS(ph)PQQSAALPR ddPTM_A459_Selumetinib_30min_R1 1 ESRSPQQSAALPR 13 1 E5RJN3;A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4 E5RJN3 NCAPH2 Condensin-2 complex subunit H2 1 ES(0.028)RS(0.971)PQQS(0.001)AALPR 130.47 0.007698600000000002 9885900.0 1285.8 1272.9 2268.6 2313.6 1780.3 1671.1 1397.3 1252.3 836.15 1159.7 True False 1315.7566382687285 1123.8682762448443 1960.536580527807 1909.573191650773 1619.2721793374938 1654.2902512374005 1291.9005360273165 1219.084935956314 1418.8854800202548 1308.5587914345974 1.0055005910939927 0.8588595969866409 1.4982411133231808 1.4592949160176993 1.2374470218202849 1.2642078155493275 0.9872697692176152 0.9316241226118762 1.0843116024345412 1.0 10.353763028463963 -7.265768212101662 24.17824703517588 0.9951033621435401 1.228386176020657 0.26162976092070855 0.1805011837847868 362.4890419351859 2024627.2986374707 0.0820161473865431 0.05752306420076574 5.422902396412826e-08 7.265768212101662 0.2332828138771168 ESRS(ph)PQQSAALPR ddPTM_A459_Selumetinib_30min_R2 3 ESRSPQQSAALPR 13 1 E5RJN3;A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4 E5RJN3 NCAPH2 Condensin-2 complex subunit H2 1 ES(0.02)RS(0.927)PQQS(0.054)AALPR;ES(0.452)RS(0.548)PQQSAALPR;ES(0.246)RS(0.754)PQQSAALPR 119.0 0.013135 5119800.0 41631.0 37954.4 41040.0 47309.8 41214.0 28241.6 31447.4 30858.7 28025.2 41760.2 True False 39317.31568209725 40865.380437368935 38399.531080973466 40866.1236260429 36036.3288621652 32131.624048280493 32909.76641184095 30948.493708067217 33631.02308951369 40554.47451996994 0.9694939004261174 1.0076663776581767 0.9468629919508553 1.0076847033468403 0.8885906990218823 0.7923077398637765 0.8114953232999096 0.7631338853331087 0.8292802085982649 1.0 15.307573480468841 -6.471040105036448 3.71817210414324 0.8232389046838691 0.981388974482388 0.533146002290297 0.062428636969551955 0.1592998059000369 4.463184918053747 0.019344048995757247 0.021295339199497307 3.3803361896250076e-07 6.471040105036448 0.15815006979851898 ESS(ph)AVFSK ddPTM_A459_Selumetinib_30min_R2 1 ESSAVFSK 8 0 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 ES(0.237)S(0.763)AVFSK 82.26100000000002 0.041744 2705200.0 31430.0 24358.0 31866.0 32757.0 30180.0 36295.0 31283.0 39665.0 33960.0 32315.0 True False 29683.24642425877 26226.180276685507 29815.776253077493 28295.440091023156 26388.51858737676 41294.306796794066 32737.72148608852 39780.41858310578 40752.94892168064 31381.981985546736 0.9458690798410906 0.8357082190909491 0.9500921983451978 0.9016460497636792 0.8408811973549101 1.315860381788905 1.043201207022749 1.2676196997827294 1.2986097863560622 1.0 14.937648850734433 -6.75326580562034 24.999991840460925 1.1929183898426974 0.895002003177886 0.6698936681095135 0.1017889399953401 102.83333445978086 314529.3910891179 0.0323225791838504 0.03179226690728162 1.764957265499405e-07 6.75326580562034 -0.29791638666481135 ESS(ph)ETPDQFMTADETR ddPTM_A459_Selumetinib_30min_R2 1 ESSETPDQFMTADETR 16 0 H0YE40;H0Y2P0;H0YD13;P16070-8;P16070-5;P16070-7;P16070-3;P16070-6;P16070-4;P16070-17;P16070-16;P16070-10;P16070-11;P16070-13;P16070-14;P16070-12;P16070-18;P16070 H0YE40 CD44 CD44 antigen 1 ES(0.261)S(0.64)ET(0.099)PDQFMTADETR 155.63 0.00050366 0.0 8811.2 4043.4 6954.0 7579.7 5869.1 4729.1 10424.0 7357.0 5957.0 6245.1 True False 8321.508778028277 4353.515778419829 6506.587210942724 6547.331784288187 5131.77118758028 5380.490598504447 10908.736654764143 7378.407651983088 7148.566452486799 6064.787736281545 1.3721022300988852 0.7178348142962486 1.0728466508428958 1.0795648700316263 0.846158416539518 0.8871688231257611 1.7987004869938827 1.2165978386750518 1.1787001892451627 1.0 12.56624143748143 ESS(ph)NPSDRWR ddPTM_A459_Selumetinib_30min_R1 1 ESSNPSDRWR 10 1 Q9Y388 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 ES(0.004)S(0.994)NPS(0.002)DRWR 134.75 0.0097219 21687000.0 3621.8 3338.8 5723.9 5993.5 4777.8 3514.5 3983.6 3842.8 1969.9 2673.2 True False 3706.180893203984 2947.89174383399 4946.625819132117 4946.847736928991 4345.6488335891 3479.1473209106834 3683.113844785239 3740.8764608264196 3342.776424196497 3016.331259173032 1.2287048652010732 0.9773103450985667 1.6399478021814824 1.640021374272147 1.4407067593698308 1.1534367488087296 1.2210574795405644 1.2402074372468068 1.1082258999341354 1.0 11.558579161452668 -6.767473995578013 24.89065034904138 1.1643779329402262 1.3909640591422716 0.2822016766092649 0.19057539302708773 224.61564349594886 926453.3705980511 0.07343242331559365 0.06642878499928977 1.7081499965687247e-07 6.767473995578013 0.22658612620204543 ESS(ph)PEKEAEEGCPEK ddPTM_A459_Selumetinib_30min_R1 2 ESSPEKEAEEGCPEK 15 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.208)S(0.792)PEKEAEEGCPEK;ES(0.105)S(0.895)PEKEAEEGCPEK 150.9 0.0012189 42990000.0 8343.2 11035.2 7207.3 6766.5 6740.9 8062.6 9607.8 9272.099999999999 6690.200000000001 10346.6 True False 8537.580326958827 9743.193653874705 6228.588246865058 5584.857797936098 6131.186785202555 7981.497564255081 8883.07591071584 9026.173787974556 11352.780767124936 11674.686894418557 0.7312898756231724 0.8345571698828804 0.5335122306228894 0.47837324019422833 0.5251692692618384 0.6836583829987665 0.7608834387637982 0.7731405449759681 0.9724270012373935 1.0 13.511096238098785 -7.961268345506119 1.1836705152718983 1.005292213951797 0.6246863489653102 0.6416454367330995 0.10219556958844848 0.3421685270619596 0.8670253429401605 0.10507576261600858 0.037262869749633526 1.0932806321502848e-08 7.961268345506119 -0.38060586498648685 ESS(ph)PEKEAEEGCPEK ddPTM_A459_Selumetinib_30min_R2 2 ESSPEKEAEEGCPEK 15 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.256)S(0.744)PEKEAEEGCPEK;ES(0.404)S(0.596)PEKEAEEGCPEK 218.34 1.3606e-08 30322000.0 139333.0 99087.0 110233.0 102838.0 94655.0 93348.0 141672.0 141299.0 89210.0 88592.0 True False 131589.4296541918 106686.65428507804 103140.72879261548 88831.28699455482 82763.59267356346 106205.83967122556 148260.02871774219 141710.15669669127 107054.4927356635 86034.1187703405 1.5295028476488108 1.2400505265808257 1.198835186165379 1.0325123133030638 0.9619857081873834 1.2344618761625428 1.7232701495264633 1.647139050438494 1.2443260216500245 1.0 16.392621286099526 -7.024683331562061 24.360545898784203 1.460648396227871 1.1778252637331879 0.13532280457598 0.23631215683160842 820.3963113449754 809665.4487084468 0.09079468479818505 0.07071762694983925 9.447494949862027e-08 7.024683331562061 -0.28282313249468305 ESS(ph)PEKEAEEGCPEKESEEGCPK ddPTM_A459_Selumetinib_30min_R1 2 ESSPEKEAEEGCPEKESEEGCPK 23 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.063)S(0.924)PEKEAEEGCPEKES(0.013)EEGCPK;ES(0.094)S(0.906)PEKEAEEGCPEKESEEGCPK 73.461 0.0014231 121989000.0 2237.6 2982.8 3351.3 3854.9 2522.94 3173.3 2853.0 2995.8999999999996 2062.82 2750.06 True False 2289.7317263883265 2633.5723893339004 2896.2118673731998 3181.7140804350665 2294.7405224612344 3141.379483125871 2637.7959130365225 2916.4389999453165 3500.4548775882113 3103.05698885283 0.7378954800423495 0.8487025532545913 0.933341500906144 1.025348258786351 0.7395096289577259 1.0123499163601275 0.8500636380550942 0.9398599543682553 1.1280665776242464 1.0 11.599474477429583 -1.9356258506900252 0.21835697226425566 1.0167082333112438 1.0816676749923454e-15 0.3348918907966558 0.09840083610953987 57.25914875347577 0.8537810806761713 0.15932227568595617 19.718042054548572 0.011597760853040734 1.9356258506900252 -1.0167082333112427 ESS(ph)PEKEAEEGCPEKESEEGCPK ddPTM_A459_Selumetinib_30min_R2 4 ESSPEKEAEEGCPEKESEEGCPK 23 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 ES(0.169)S(0.83)PEKEAEEGCPEKESEEGCPK;ES(0.207)S(0.793)PEKEAEEGCPEKESEEGCPK;ES(0.056)S(0.944)PEKEAEEGCPEKESEEGCPK;ES(0.281)S(0.719)PEKEAEEGCPEKESEEGCPK 107.49 2.1553e-05 258808000.0 333102.4 295610.2 260160.1 228736.5 215694.1 170316.4 254588.0 216349.0 121350.8 232616.2 True False 314589.90212255873 318282.55180339346 243421.68240689958 197582.19410752883 188596.67882828048 193775.9381216558 266426.8464565516 216978.53977149513 145624.35082464924 225899.96589652938 1.3926071253443777 1.4089535186082267 1.0775640511534907 0.8746446389373466 0.8348681155386486 0.8577953403074546 1.1794018887926039 0.9605071825060806 0.6446408712224004 1.0 17.78532452736829 -5.399583810262301 2.8469873292936203 0.9129761509519856 1.4100694593855463 0.6960332265941755 0.12874438690196552 0.15371507447078214 2.363783506419921 0.037012149896484055 0.09257488347075638 3.98488864407881e-06 5.399583810262301 0.4970933084335607 ESS(ph)PFLSPLEASR ddPTM_A459_Selumetinib_30min_R1 1 ESSPFLSPLEASR 13 0 Q9UP95-3;Q9UP95-5;Q9UP95-2;Q9UP95-6;Q9UP95;Q9UP95-4 Q9UP95-3 SLC12A4 Solute carrier family 12 member 4 1 ES(0.396)S(0.603)PFLSPLEASR 129.54 0.0017155 5110200.0 1732.2 1627.2 2354.0 1834.2 1770.3 1669.0 1898.3 2076.3 899.7 1426.2 True False 1772.556889725534 1436.6866675352437 2034.3397295964303 1513.8914021982405 1610.1766775718509 1652.2113753307526 1755.109702669902 2021.2297792270983 1526.725188511899 1609.2666623644247 1.1014687193738257 0.8927586093310248 1.2641408519626351 0.9407337128167101 1.00056548440896 1.0266858898967255 1.090627018949859 1.2559943149865507 0.9487086411575498 1.0 10.652187691267098 -7.28191522523927 9.737377709235167 1.0952195682986965 1.0353276678096903 0.008729020293067102 0.11987012149194064 1.4732112113988423 676.0359421941224 0.0476421732104959 0.03273504574384817 5.224981712632166e-08 7.28191522523927 -0.05989190048900617 ESS(ph)PFLSPLEASR ddPTM_A459_Selumetinib_30min_R2 1 ESSPFLSPLEASR 13 0 Q9UP95-3;Q9UP95-5;Q9UP95-2;Q9UP95-6;Q9UP95;Q9UP95-4 Q9UP95-3 SLC12A4 Solute carrier family 12 member 4 1 ES(0.004)S(0.996)PFLSPLEASR 122.52 0.0019473 0.0 17479.0 16034.0 16949.0 22443.0 20551.0 14424.0 17996.0 16686.0 15981.0 17889.0 True False 16507.587153980876 17263.756242564054 15858.519792675897 19386.224683665558 17969.19965172895 16410.775071964683 18832.849658397492 16734.553497483994 19177.64654644813 17372.4980887961 0.9502137844313235 0.9937405751506644 0.9128520096314416 1.1159146246312242 1.0343474818579879 0.9446410635985821 1.0840611155711224 0.9632784768171292 1.1039083986900082 1.0 14.08451760171446 -5.740617215989696 24.99996816587118 1.031865934187158 0.9564159847223 0.31130284740294756 0.05625130159773706 314.6434494216178 377771.2311041479 0.014632293253149098 0.025308531276705334 1.8171165505284387e-06 5.740617215989696 -0.07544994946485806 ESS(ph)PIPS(ph)PTSDRK ddPTM_A459_Selumetinib_30min_R1 3 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 2 ES(0.085)S(0.915)PIPS(0.87)PT(0.114)S(0.016)DRK;ES(0.051)S(0.949)PIPS(0.852)PT(0.127)S(0.02)DRK;ES(0.048)S(0.952)PIPS(0.895)PT(0.102)S(0.003)DRK 147.39 0.0019318 19649200.0 9390.0 9558.6 8173.9 8604.599999999999 8825.6 8531.0 8710.4 8421.3 4978.8 7509.7 True False 9608.768730240608 8439.474668327415 7063.929276018796 7101.968138346405 8027.326038286233 8445.185885528255 8053.367515216728 8197.93976776244 8448.65996283544 8473.64314567249 1.1339595691078672 0.9959676756788461 0.833635445177599 0.8381245252195212 0.9473287817632263 0.9966416735216461 0.9504020144310187 0.9674634188423604 0.997051659786994 1.0 13.048766657781032 -7.978199015663143 1.0626583503060414 1.00126610667462 0.9467503856651015 0.03296735719036037 0.08027289553413507 1.9683006862248729 4.083409267001146 0.08051517864306883 0.029314464253876855 1.0514799222050965e-08 7.978199015663143 -0.054515721009518514 ESS(ph)PIPS(ph)PTSDRK ddPTM_A459_Selumetinib_30min_R2 1 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 2 ES(0.017)S(0.983)PIPS(0.831)PT(0.134)S(0.035)DRK 172.85 0.00055405 19830000.0 46963.0 38857.0 44741.0 45897.0 47712.0 33831.0 42177.0 41309.0 37967.0 45217.0 True False 44352.98446778444 41837.2069550525 41862.41277031757 39645.749423258836 41717.99200930815 38490.91316275906 44138.314072140005 41429.20235092689 45561.460886615096 43911.467722124944 1.010054702531317 0.9527626637260561 0.9533366781367012 0.9028563944648834 0.9500477705118565 0.876557199279524 1.0051659933448494 0.9434711363576819 1.0375754501063692 1.0 15.42231013628771 -8.254038443387214 24.720420380258574 1.018787726162063 0.9474494749098702 0.33845269674675715 0.03880244087356638 488.3943644558245 1631338.7487651373 0.027139242004937045 0.009814257331448754 5.571364294946079e-09 8.254038443387214 -0.07133825125219284 ESS(ph)PIPSPT(ph)SDR ddPTM_A459_Selumetinib_30min_R2 2 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 2 ES(0.002)S(0.998)PIPS(0.033)PT(0.737)S(0.23)DR;ES(0.361)S(0.639)PIPS(0.47)PT(0.513)S(0.017)DR 219.95 5.84e-06 40809000.0 200054.0 172464.0 197650.0 218841.0 216331.0 163338.0 185116.0 193259.0 193926.0 174083.0 True False 188935.7995596139 185691.4342408358 184933.41418504875 189034.47827821822 189153.56575632186 185836.32686526404 193724.26080039507 193821.35169425042 232716.61874516588 169056.77146804726 1.1175878843476192 1.0983969031724505 1.093913083629438 1.118171586010365 1.1188760090102219 1.0992539680694673 1.145912459572849 1.146486768977981 1.376558990949089 1.0 17.367148278113945 -7.8597909628671285 3.3274519144787367 1.2055886709620196 1.1108332850152196 0.0902352260075554 0.08629658811850334 0.40867219985816955 8.768174994307467 0.049895881788834 0.02167412653448431 1.3810488390696545e-08 7.8597909628671285 -0.0947553859468 ESS(ph)PIPSPTSDR ddPTM_A459_Selumetinib_30min_R1 1 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ES(0.271)S(0.728)PIPSPTSDR 151.55 0.00051962 5786400.0 4153.7 4872.7 3810.0 3345.0 4338.4 3822.0 3971.2 3792.0 2384.2 4485.1 True False 4250.473128306753 4302.202018743229 3292.6229268319457 2760.858543426622 3945.992486006731 3783.554150098343 3671.649186768539 3691.423841848071 4045.8132649217177 5060.806273573606 0.8398806234693806 0.850102095630169 0.6506123231836167 0.5455372907363013 0.779716170249752 0.7476188467942774 0.7255067647898452 0.7294141767733449 0.7994404539940694 1.0 12.3051515340524 -8.747353351442795 1.9721124106470311 0.999936167643977 0.7296633183226949 0.4788568920820856 0.083510722772634 0.8250723739706288 5.456695457993175 0.0872466485698775 0.024218172681380597 1.7891495706525935e-09 8.747353351442795 -0.27027284932128204 ESS(ph)PIPSPTSDR ddPTM_A459_Selumetinib_30min_R2 1 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ES(0.061)S(0.909)PIPS(0.022)PT(0.007)SDR 89.44 0.025775 6092900.0 50835.0 43438.0 42559.0 66394.0 62727.0 48775.0 46911.0 48687.0 43254.0 54013.0 True False 48009.794208628555 46769.55492481585 39820.80027473558 57351.02266396156 54846.67347350503 55493.31351463371 49092.45445238303 48828.67110943327 51906.008617737796 52453.50434737233 0.9152828739655717 0.8916383282055926 0.7591637731394092 1.09336875348033 1.0456245803956965 1.057952451510776 0.9359232536165589 0.9308943552382379 0.9895622659258617 1.0 15.678751540067712 -5.764266208779086 24.99999990573849 1.0054321463017581 0.8589893305412957 0.5679657726916112 0.06080749360359351 58.817649596348026 520180.69582126406 0.018419040999979465 0.02873805508866584 1.7208134474314776e-06 5.764266208779086 -0.14644281576046247 ESS(ph)PIPSPTSDRK ddPTM_A459_Selumetinib_30min_R1 1 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ESS(0.997)PIPS(0.001)PT(0.001)SDRK 100.02 0.020233 8008100.0 2064.8 1855.3 2221.4 2028.1 1897.3 1728.1 1709.1 1771.7 1057.2 1717.4 True False 2112.905822598594 1638.0806134944303 1919.7460812767658 1673.9304071520282 1725.689549995522 1710.7168829892582 1580.1812109956966 1724.7087607073402 1793.9911851670317 1937.8450188926256 1.0903378763519522 0.8453104337675597 0.9906602760079326 0.8638102587319338 0.8905198987386829 0.8827934464887399 0.8154321917336224 0.8900137750401312 0.9257660791636482 1.0 10.92023747903957 -4.752345552251943 24.96850319090113 0.8951921536193347 1.0903382600903322 0.5088502320565735 0.0557410612270636 274.9695551859467 754915.7065099425 0.01329212962428836 0.15936805012457608 1.7687011074537018e-05 4.752345552251943 0.1951461064709975 ESS(ph)PIPSPTSDRK ddPTM_A459_Selumetinib_30min_R2 1 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ES(0.13)S(0.87)PIPSPTSDRK 122.97 0.0013065 10011000.0 41422.0 25953.0 32961.0 33499.0 37159.0 32200.0 31520.0 32875.0 28920.0 34351.0 True False 39119.931065403965 27943.511647952175 30840.325145223323 28936.378411001766 32490.75421432512 36635.25771750294 32985.742455695115 32970.660807250766 34704.80809231463 33359.19737538347 1.1726880183955348 0.8376553948079202 0.9244924210311223 0.8674183040253419 0.9739669048003178 1.0982056104424427 0.9888050388177524 0.9883529401573848 1.0403370231540439 1.0 15.025796957406248 -6.528063640589648 24.60631920928756 1.022024026929566 0.938143459597157 0.1253013233902166 0.08897117523493586 212.52785954177173 1008595.5468431334 0.028435367292947954 0.02853198026461798 2.9643969612694915e-07 6.528063640589648 -0.083880567332409 ESS(ph)PLPK ddPTM_A459_Selumetinib_30min_R1 4 ESSPLPK 7 0 Q9HCE3 Q9HCE3 ZNF532 Zinc finger protein 532 1 ES(0.011)S(0.989)PLPK;ES(0.078)S(0.922)PLPK;ES(0.004)S(0.996)PLPK;ES(0.003)S(0.997)PLPK 136.8 0.0028505 55116900.0 48882.9 55659.0 39963.0 41254.1 46443.3 40833.5 53372.0 52037.1 27187.5 49267.0 True False 50021.77646043432 49142.41840483288 34536.244101045915 34049.84587036661 42242.51171523057 40422.75206385158 49346.10706995629 50656.907067677304 46135.20180356478 55590.899351218686 0.8998195216163151 0.8840011400850913 0.6212571572704516 0.6125075555126841 0.7598817829577803 0.7271469347611016 0.887665205021989 0.911244604042672 0.829905656177397 1.0 15.76256110178775 -7.292473749121451 6.444925464129403 0.9007946269184278 0.7449986966976316 0.3887653683270961 0.09582071092266059 0.24171427010873833 34.313544265699264 0.04377442940118404 0.029944562181488846 5.099484204152257e-08 7.292473749121451 -0.15579593022079619 ESS(ph)PLPK ddPTM_A459_Selumetinib_30min_R2 2 ESSPLPK 7 0 Q9HCE3 Q9HCE3 ZNF532 Zinc finger protein 532 1 ES(0.066)S(0.934)PLPK;ES(0.019)S(0.981)PLPK 97.635 0.022374 54374000.0 804880.0 611730.0 678330.0 807790.0 732120.0 581780.0 714820.0 756560.0 627450.0 579870.0 True False 760147.991789927 658647.7239780286 634686.9863098632 697767.6084845258 640144.5403641568 661914.9141269841 748060.5463889582 758761.4643447504 752957.532417801 563127.6464168037 1.349868003509984 1.1696242018466358 1.1270748121645127 1.23909314863946 1.136766316549034 1.1754260660771432 1.3284031624959056 1.3474058131806703 1.3370992122459089 1.0 19.10310245532024 -7.24980789549982 24.283348548775624 1.2821775322436286 1.1939143665251186 0.0262309000878288 0.11138222798682923 1058.4490218857977 2209755.9656994306 0.040923555728622225 0.03138466312381736 5.625901245642457e-08 7.24980789549982 -0.08826316571851 ESS(ph)PLSSR ddPTM_A459_Selumetinib_30min_R1 1 ESSPLSSR 8 0 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7;A0A0A0MS66;Q14693-6 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 ES(0.045)S(0.954)PLS(0.001)SR 106.88 0.013539 9961100.0 4423.1 4933.6 5055.1 5305.0 5225.5 4443.4 5203.6 4218.6 2614.5 3697.2 True False 4526.1496241456025 4355.9718184315825 4368.645185676684 4378.58133718333 4752.854447636955 4398.703430284402 4811.088262557607 4106.709024055983 4436.615544475223 4171.771633777695 1.08494664173336 1.044153947249286 1.0471918333939851 1.049573591644172 1.1392892192742268 1.0543969844056906 1.1532482323825064 0.9844040816628318 1.063484757543572 1.0 12.026444470364014 -7.7894604660870534 24.999986922017257 1.0179583315517957 1.0789618678930448 0.3553302597090673 0.04050033408013113 266.16686110541883 237466.43006444507 0.02174331311309643 0.010448738721179527 1.6238261609726847e-08 7.7894604660870534 0.06100353634124911 ESS(ph)PLSSR ddPTM_A459_Selumetinib_30min_R2 2 ESSPLSSR 8 0 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7;A0A0A0MS66;Q14693-6 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 ES(0.042)S(0.958)PLSSR;ES(0.022)S(0.978)PLSSR 128.6 0.0042872 21230000.0 81690.0 74085.0 84363.0 92829.0 102198.0 82129.0 71461.0 88504.0 82081.0 85818.0 True False 77149.9968309799 79767.08127917931 78935.17642748941 80185.53006104322 89358.9735782879 93441.52425716772 74784.0780972852 88761.53198737412 98499.4935347608 83340.21135805821 0.9257235561776653 0.9571259777164771 0.9471439433763462 0.9621469486864943 1.0722191859385983 1.1212057509154951 0.8973348744699852 1.065050478526195 1.1818963730674152 1.0 16.346725138395236 -6.191870878999226 5.0619919718108175 1.054776151220795 0.9468240289475984 0.36351046029264655 0.07030639964567638 0.26585946608400335 13.093291887611455 0.021688130872988872 0.028083863862046053 6.428788245543229e-07 6.191870878999226 -0.1079521222731965 ESS(ph)PLY(ph)SPTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R1 1 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.09)S(0.906)PLY(0.523)S(0.421)PT(0.035)FS(0.025)DSTSAVK 126.07 0.020162 7135700.0 1545.0 1782.3 2207.9 2537.5 1946.1 1803.2 1719.2 1788.2 1242.6 1618.3 True False 1580.9954939533254 1573.627487431209 1908.0793071265753 2094.3732597743083 1770.075598611862 1785.0614451746026 1589.5193598641386 1740.7711271077856 2108.601444086791 1826.0245685768796 0.8658128270341299 0.8617778284646096 1.0449362730172056 1.1469578754937386 0.9693602315501036 0.9775670469569849 0.8704808178473401 0.9533119964888881 1.1547497664448947 1.0 10.834490461115424 -5.253113870555718 24.237142048595956 1.009634642989253 0.8637952911888794 0.35277210020829874 0.08151664319692484 492.48750208505606 1433711.5751525294 0.02232658604678403 0.05695955616597069 5.583237849208455e-06 5.253113870555718 -0.14583935180037366 ESS(ph)PLYS(ph)PTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R1 7 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.007)S(0.993)PLYS(0.796)PT(0.079)FS(0.123)DS(0.002)TSAVK;ES(0.057)S(0.943)PLYS(0.789)PT(0.03)FS(0.03)DS(0.129)T(0.02)S(0.003)AVK;ES(0.085)S(0.915)PLYS(0.476)PT(0.476)FS(0.044)DS(0.002)T(0.001)SAVK;ES(0.143)S(0.857)PLY(0.033)S(0.921)PT(0.016)FS(0.031)DSTSAVK;ES(0.056)S(0.942)PLY(0.002)S(0.767)PT(0.192)FS(0.041)DSTSAVK;ES(0.065)S(0.935)PLYS(0.959)PT(0.02)FS(0.02)DS(0.001)TSAVK;ES(0.008)S(0.992)PLYS(0.911)PT(0.017)FS(0.025)DS(0.039)T(0.007)S(0.001)AVK 226.22 2.3405e-17 246094800.0 23009.1 26906.96 28894.700000000004 29130.749999999996 27135.83 23718.73 25016.05 25316.97 14296.839999999998 21397.56 True False 23545.167262085106 23756.68061449367 24970.958447225992 24043.611364402117 24681.39896771989 23480.141111083743 23129.0692079626 24645.481714491674 24260.693280120544 24144.14525588452 0.9751915842349637 0.9839520249201444 1.0342448731391707 0.9958360964773478 1.0222519250999134 0.9724983370600397 0.9579576730853819 1.0207643075906763 1.0048271754083993 1.0 14.559385770087397 -6.253326173801397 0.0026419247691732823 1.2322913447238943 0.7608311156477733 0.00758821474160154 0.023216089515466328 708766.7621744655 543.4963622778159 48006.41503258916 48981.82347125657 5.580509171113393e-07 6.253326173801397 -0.47146022907612106 ESS(ph)PLYS(ph)PTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R2 5 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.058)S(0.942)PLYS(0.913)PT(0.043)FS(0.043)DSTSAVK;ES(0.405)S(0.595)PLYS(0.516)PT(0.24)FS(0.24)DS(0.003)T(0.001)SAVK;ES(0.04)S(0.96)PLYS(0.82)PT(0.155)FS(0.025)DSTSAVK;ES(0.063)S(0.937)PLYS(0.958)PT(0.016)FS(0.025)DS(0.001)TSAVK;ES(0.339)S(0.431)PLY(0.256)S(0.628)PT(0.077)FS(0.113)DS(0.152)T(0.003)S(0.001)AVK 209.23 2.5449e-10 190077000.0 588423.0 529938.0 563981.0 601185.0 617700.0 485478.0 492784.0 518449.0 437772.0 617980.0 True False 555720.805303901 570582.54058076 527695.0764760836 519302.5658980292 540099.0036919358 552348.1877695007 515699.43243297096 519957.6007561483 525338.6323716727 600137.3116951315 0.9259894268767045 0.9507533183849345 0.8792905659965892 0.8653062487170167 0.899959047982514 0.9203696837467963 0.8593024002729316 0.8663977236934165 0.8753640577484101 1.0 19.19493310222019 -5.262905956211114 24.968948303480772 0.8896180097806446 0.9383713742270406 0.14080093742367805 0.039877967523944055 188.40107510643202 3207658.2799113365 0.009749838278953416 0.022266311640573 5.4587605438333956e-06 5.262905956211114 0.048753364446396 ESS(ph)PLYSPTFS(ph)DSTSAVK ddPTM_A459_Selumetinib_30min_R1 1 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.006)S(0.994)PLYS(0.046)PT(0.308)FS(0.538)DS(0.09)T(0.015)S(0.003)AVK 268.82 1.1831e-52 182260000.0 11362.0 13372.0 13859.0 14953.0 13421.0 12460.0 12428.0 12024.0 6725.6 9377.8 True False 11626.712493396559 11806.400023525852 11977.023922037772 12341.739252573485 12207.07291967 12334.66371277482 11490.545954159794 11705.084460543569 11412.851981611238 10581.53197750743 1.0987740261155767 1.1157552657424328 1.1318799534412087 1.1663471110617658 1.153620567004654 1.1656784423081576 1.0859057061477113 1.1061805119924424 1.078563293658319 1.0 13.369260893235044 -8.559088742814932 0.858852830130215 1.0010890495264906 1.1368886502736366 0.7455257000682038 0.0239275122243749 0.364635251850728 0.5943560835600215 0.025143551249523496 0.008899597780670319 2.7600138232145925e-09 8.559088742814932 0.13579960074714603 ESS(ph)PLYSPTFS(ph)DSTSAVK ddPTM_A459_Selumetinib_30min_R2 1 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 ES(0.056)S(0.944)PLYS(0.032)PT(0.342)FS(0.587)DS(0.029)T(0.005)S(0.005)AVK 269.34 3.269899999999998e-110 0.0 19959.0 16951.0 17966.0 21192.0 17391.0 11745.0 15701.0 18565.0 13318.0 21354.0 True False 18849.75868220746 18251.087193944328 16810.087119901786 18305.613041760917 15206.18710248738 13362.767139505344 16431.12761094128 18619.02107639881 15981.972136011287 20737.45453564491 0.9089716700671843 0.8801025778054462 0.8106147787332093 0.8827319192090822 0.7332716306309427 0.6443783694154235 0.792340621299416 0.8978450582927237 0.7706814791825302 1.0 14.339951197800074 -5.207751608007313 1.2980274404178664 0.7996182747488773 0.9201448885910966 0.09140566506658643 0.09247094043150735 1.5510113035476 3.757020820185676 0.029403510969657234 0.20262443021328658 6.197954618319082e-06 5.207751608007313 0.1205266138422193 ESS(ph)PLYSPTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R1 9 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ES(0.088)S(0.912)PLYSPTFSDSTSAVK;ES(0.002)S(0.998)PLYSPTFSDSTSAVK;ESS(1)PLYSPTFSDSTSAVK;ES(0.001)S(0.998)PLYSPTFSDSTSAVK;ESS(0.65)PLYS(0.349)PTFSDSTSAVK;ES(0.233)S(0.767)PLYSPTFSDSTSAVK;ES(0.025)S(0.973)PLYS(0.002)PTFSDSTSAVK;ES(0.003)S(0.997)PLYSPTFSDSTSAVK;ES(0.096)S(0.69)PLY(0.016)S(0.053)PT(0.053)FS(0.014)DS(0.039)T(0.039)S(0.001)AVK 351.46 1.0051999999999992e-183 4456883400.0 24432.159999999996 27316.899999999998 29734.84 32074.1 25665.66 23791.84 25601.03 23507.200000000004 14879.75 21007.5 True False 25001.38179129235 24118.624648717727 25697.012049784666 26472.960540424487 23344.20558464031 23552.515690862336 23669.923695592486 22883.712693853126 25249.848976058594 23704.017255378374 1.0547318423681795 1.0174910180359946 1.084078355703782 1.1168132496367402 0.9848206459326456 0.9936086122920087 0.9985616969723496 0.9653938590793456 1.06521391306908 1.0 14.532843961173894 -6.283036992385443 24.97074232105308 0.9990180140281995 1.065779488447198 0.49049832312339325 0.0333730474566395 698.5931091760564 807697.4143168314 0.010577075251844321 0.012002929353315123 5.21150318612558e-07 6.283036992385443 0.0667614744189986 ESS(ph)PLYSPTFSDSTSAVK ddPTM_A459_Selumetinib_30min_R2 8 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ES(0.085)S(0.915)PLYSPTFSDSTSAVK;ES(0.067)S(0.933)PLYSPTFSDSTSAVK;ES(0.158)S(0.842)PLY(0.001)SPTFSDSTSAVK;ES(0.007)S(0.976)PLYS(0.017)PTFSDSTSAVK;ES(0.147)S(0.853)PLYSPTFSDSTSAVK;ES(0.015)S(0.985)PLYSPTFSDSTSAVK;ES(0.074)S(0.926)PLYSPTFSDSTSAVK;ES(0.007)S(0.993)PLYSPTFSDSTSAVK 318.32 6.585099999999996e-127 735276200.0 714793.0 744447.0 713040.0 765971.0 719734.0 533479.0 621986.0 594567.0 482485.0 681999.0 True False 675067.6666030928 801543.6911256125 667163.7826992513 661644.428426323 629314.5804164024 606960.8898098058 650909.581441878 596297.0915341342 578995.4817572751 662307.9168237924 1.0192655854704138 1.210228159387779 1.0073317346087995 0.9989982176256457 0.9501842940884431 0.9164330885860273 0.9827899756406703 0.9003321210378641 0.8742089095566667 1.0 19.337142577865215 -5.707951343247116 1.7427951802879156 0.9347652328526453 1.1137999830538468 0.5565988810135645 0.05887470842333058 0.24306021609448134 1.4931311874483022 0.01755548366802868 0.03929923595272277 1.959064147536945e-06 5.707951343247116 0.1790347502012014 ESS(ph)PPREEAPPPPPPTEDSCAK ddPTM_A459_Selumetinib_30min_R2 2 ESSPPREEAPPPPPPTEDSCAK 22 1 C9JR56;Q9UPW6-2;Q9UPW6 C9JR56 SATB2 DNA-binding protein SATB;DNA-binding protein SATB2 1 ES(0.157)S(0.843)PPREEAPPPPPPTEDSCAK;ES(0.182)S(0.818)PPREEAPPPPPPTEDSCAK 126.91 1.6039e-05 9918800.0 45637.0 45314.0 47024.0 50048.0 52561.0 40310.0 42801.0 44348.0 33929.0 46550.0 True False 43100.67823938584 48789.438092525146 43998.527035860025 43231.37606238445 45957.81727869814 45862.3366022529 44791.33130857256 44477.0453377934 40715.748055468306 45205.98054857499 0.953428677275854 1.0792695457650705 0.9732899607958393 0.9563198394940515 1.016631355431286 1.0145192305467778 0.9908275578812658 0.9838752483203339 0.9006717155867947 1.0 15.46422602690265 -8.019298425212549 19.885501235309743 0.9476482362599143 0.9988426201208944 0.1738126328381948 0.0407013254779109 83.04996487506625 85569.83872759866 0.025352431186138412 0.010029171788859587 9.565365618487396e-09 8.019298425212549 0.051194383860980075 ESS(ph)PSHGLLK ddPTM_A459_Selumetinib_30min_R1 1 ESSPSHGLLK 10 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 ES(0.012)S(0.952)PS(0.035)HGLLK 164.33 0.00037717 20225000.0 4344.6 4414.8 3979.7 4322.0 5738.9 3582.4 4798.6 4532.4 1546.7 3136.4 True False 4445.820726880016 3897.9131636151596 3439.2785989273193 3567.243833988004 5219.817508285088 3546.3643085589492 4436.637738624978 4412.186028689929 2624.6369335015593 3538.9874911231072 1.2562408705968957 1.1014204411268338 0.9718255878423168 1.0079843014240013 1.4749465832750273 1.0020844429245217 1.2536460639528846 1.2467368250826198 0.7416349846064654 1.0 11.789120947095885 -8.25645244464154 24.98695743306518 0.8708174861309397 1.1585520948602077 0.3595213417151656 0.15656559532846204 418.9047308631559 2098942.1361144716 0.11276890094634286 0.03967222455504862 5.540482090397657e-09 8.25645244464154 0.28773460872926804 ESSAMAS(ph)PLPR ddPTM_A459_Selumetinib_30min_R2 2 ESSAMASPLPR 11 0 Q9C0C2;E9PKK0;E9PKE7 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 ESSAMAS(1)PLPR;ESSAMAS(1)PLPR 120.55 0.0046978 18109400.0 78433.0 63748.0 75477.0 91755.0 105330.0 61031.0 61052.0 76763.0 51386.0 66116.0 True False 74074.00785217586 68637.2666178729 70620.89199314406 79257.81071379635 92097.50373785272 69437.46626574299 63891.038972242975 76986.36762120132 61664.63584480218 64207.05929000188 1.1536738899317636 1.0689987577201012 1.099892952177938 1.2344096052712092 1.4343828351004053 1.081461556308273 0.9950781063444823 1.1990327617011638 0.9604027427308822 1.0 15.97044430373179 -8.265855066972295 24.656680273038358 0.9802013392763503 1.1571671750061172 0.28335483931671646 0.11332344755415111 469.00357104412956 2618797.4302863358 0.10544328308536259 0.030928076400261316 5.421817974642594e-09 8.265855066972295 0.17696583572976687 ESSANNSVS(ph)PSESLR ddPTM_A459_Selumetinib_30min_R1 4 ESSANNSVSPSESLR 15 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 ESSANNS(0.005)VS(0.547)PS(0.274)ES(0.174)LR;ESSANNSVS(0.998)PS(0.002)ESLR;ESS(0.001)ANNS(0.079)VS(0.92)PSESLR;ESSANNS(0.079)VS(0.921)PSESLR 301.04 1.2458999999999993e-80 98985000.0 8384.5 9318.7 9595.6 10169.599999999999 9554.1 8140.8 8569.9 8618.800000000001 5863.0 7352.5 True False 8579.84253660302 8227.662271853904 8292.570224857902 8393.670267034791 8689.933341913358 8058.9109432549985 7923.465543333927 8390.20142619203 9949.08278342254 8296.264994414825 1.034181350569094 0.9917308906348693 0.9995546466320192 1.0117408584086383 1.0474512744908169 0.9713902519604163 0.9550641823360424 1.011322737622345 1.1992243244544887 1.0 13.018246261265295 -8.037920637504268 24.571425752015404 1.1014993841537633 1.0007712506646098 0.3641798871711792 0.051286906759438367 441.38310593153386 285999.90789420006 0.0322448510075505 0.012194630540722605 9.16387934545009e-09 8.037920637504268 -0.10072813348915344 ESSANNSVS(ph)PSESLR ddPTM_A459_Selumetinib_30min_R2 4 ESSANNSVSPSESLR 15 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 ESSANNS(0.002)VS(0.974)PS(0.024)ESLR;ESS(0.012)ANNS(0.026)VS(0.961)PS(0.001)ESLR;ESSANNS(0.001)VS(0.992)PS(0.008)ESLR;ESSANNS(0.009)VS(0.886)PS(0.103)ES(0.001)LR 262.73 1.3453e-36 98055000.0 109964.0 94816.0 110975.0 122008.0 117479.0 84563.0 82122.0 92520.0 77413.0 97698.0 True False 103852.64110076959 102088.08231850764 103834.98932044412 105390.29992446027 102720.23774441474 96210.78566351552 85940.83572165584 92789.21788248947 92897.7630999428 94877.20489011117 1.0946005546965043 1.076002211877429 1.0944145059997081 1.1108073856784209 1.0826650918246121 1.0140558606774823 0.905811209564978 0.9779927432512366 0.9791368032768144 1.0 16.533773887846372 -6.884456228098958 3.3061046788035453 0.9632839266057439 1.0927250042900645 0.8548514769520963 0.024538738379833357 0.08440742586598883 1.820312286047317 0.009125768866434125 0.007958687157128741 1.304799470829304e-07 6.884456228098958 0.12944107768432056 ESSEARKGFS(ph)Y(ph)LVT(ph)GVT(ph)TVGVAYAAK ddPTM_A459_Selumetinib_30min_R1 1 ESSEARKGFSYLVTGVTTVGVAYAAK 26 2 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 4 ES(0.01)S(0.01)EARKGFS(0.979)Y(0.977)LVT(0.846)GVT(0.411)T(0.411)VGVAY(0.357)AAK 45.011 0.040556 0.0 450.88 458.13 446.89 486.04 518.37 369.82 323.81 502.9 121.36 407.93 True False 461.38462674024333 404.4919266211413 386.2047925910573 401.1622381007702 471.48352502565666 366.09994656969394 299.38475099907316 489.5614583505792 205.93905621629872 460.29178907468776 1.0023742280255585 0.8787728484887393 0.8390434106318395 0.8715389837981161 1.0243144375298707 0.7953649299407552 0.6504238357171617 1.063589379542771 0.44740979766398287 1.0 8.846404897018504 -6.9068330555617266 11.558900166160866 0.7852846409023538 0.9131220417306342 0.13089860183252655 0.16870995863024865 0.9731849597724315 114.12064049763345 0.055603531979134604 0.049041968335484847 1.2392728761524972e-07 6.9068330555617266 0.12783740082828032 ESSEEEYDS(ph)GVEEEGWPR ddPTM_A459_Selumetinib_30min_R2 1 ESSEEEYDSGVEEEGWPR 18 0 O76031 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 1 ES(0.116)S(0.029)EEEYDS(0.855)GVEEEGWPR 159.19 3.2011e-05 0.0 5462.3 4629.5 4312.1 5401.7 4771.4 2043.6 4753.7 3668.5 4040.7 3647.1 True False 5158.727233319397 4984.567763811294 4034.664180659495 4665.979141547753 4171.974075142793 2325.0873500462417 4974.75646927785 3679.174727647129 4848.952906591138 3541.7987466961968 1.456527488506081 1.407354883859767 1.139156815282925 1.3174038039005451 1.177925222045557 0.6564707698920194 1.4045847392990134 1.0387870657752865 1.3690650580059807 1.0 11.790266521768203 -5.145067799612559 1.0308452923888791 1.1171769281395476 1.546833283794617 0.25004508500157396 0.2046618169695258 1.6210971090489592 2.0775100368602994 0.06931458754158669 0.6726995304200243 7.1603161865679965e-06 5.145067799612559 0.42965635565506943 ESSFEESNIEDPLIVTPDCQEKTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ESSFEESNIEDPLIVTPDCQEKTSPK 26 1 A0A087WUU7;Q96GX5-2;Q96GX5-3;Q96GX5 A0A087WUU7 MASTL Serine/threonine-protein kinase greatwall 1 ESSFEESNIEDPLIVT(0.006)PDCQEKT(0.264)S(0.729)PK 122.82 4.2283e-09 19895000.0 6106.1 7026.7 6456.3 7219.8 4985.0 6557.5 6574.4 7088.0 4867.3 7273.7 True False 6248.360249597674 6204.010697375797 5579.569921917343 5958.997462430956 4534.10763017323 6491.537503733618 6078.487714920194 6900.0032149312065 8259.452606473227 8207.350246837825 0.7613127333033067 0.7559090949927614 0.6798259796536735 0.7260561914884616 0.5524447591255359 0.790941937226904 0.7406151232868549 0.8407102179646445 1.0063482559009196 1.0 13.00270080596166 -8.015898168947516 1.6544077601039588 1.0159963077169911 0.7066445379312852 0.7762361760001651 0.06174036921952054 0.1767479670196081 0.8673813997677238 0.055251777523368795 0.018212774902038972 9.640550436068568e-09 8.015898168947516 -0.3093517697857059 ESSIIAPAPAEDVDT(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 ESSIIAPAPAEDVDTPPR 18 0 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR 237.81 1.6199e-24 136137800.0 13603.6 12342.9 11714.7 10823.3 13141.099999999999 11242.5 11566.3 11893.6 7275.9400000000005 11055.7 True False 13920.537412002239 10897.787529941463 10123.908084240986 8933.213833503552 11952.489825249633 11129.410657373264 10693.84467891845 11578.143092142464 12346.738766367973 12474.806786637477 1.115892025431077 0.8735836727839941 0.8115482874721008 0.7161003762457034 0.9581302564182935 0.8921509445176058 0.8572352952490837 0.9281220374927582 0.9897338674289781 1.0 13.6067298504131 -8.115809863640479 2.731428081970365 0.9979742906991499 0.8818192654215345 0.15332726956466514 0.09695760395883304 0.5319877782422017 7.149500988952101 0.08408099007910122 0.026852657938982553 7.65931862429282e-09 8.115809863640479 -0.11615502527761534 ESSIIAPAPAEDVDT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 5 ESSIIAPAPAEDVDTPPR 18 0 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR;ESSIIAPAPAEDVDT(1)PPR 214.24 8.2756e-12 147881400.0 203250.0 176425.0 214357.0 238248.0 240561.0 175450.0 192500.0 210527.0 182464.0 191943.0 True False 191954.17867421565 189956.2302042135 200565.5039942552 205798.21139927642 210339.57653737382 199616.64492347513 201451.63143151382 211139.5987153791 218961.89847012822 186401.10686219425 1.0297909808879342 1.0190724368640554 1.075988803771067 1.1040611016941138 1.1284245038999539 1.0708983883397811 1.080742678102477 1.13271644288826 1.174681321136178 1.0 17.508050901273734 -5.42826946968997 2.869448586188806 1.1034619564857218 1.023625092031045 0.30745266696728657 0.04353992457601465 0.29962594715374125 4.715964781560617 0.0118022450782631 0.028529620171258006 3.730186365324193e-06 5.42826946968997 -0.07983686445467675 ESSIIAPAPAEDVDT(ph)PPRK ddPTM_A459_Selumetinib_30min_R1 2 ESSIIAPAPAEDVDTPPRK 19 1 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 ESSIIAPAPAEDVDT(1)PPRK;ESSIIAPAPAEDVDT(1)PPRK 71.65100000000002 0.017513 17221100.0 6055.6 6106.299999999999 6651.6 6401.9 4921.1 5678.6 5571.5 5508.1 3456.0 4572.799999999999 True False 6196.683697853565 5391.371557258142 5748.349254623451 5283.928343546456 4475.987373890773 5621.478439756272 5151.237269359616 5362.007295169668 5864.579583746938 5159.763422843948 1.2009627554664297 1.0448873553754014 1.1140722516799204 1.024064072424869 0.8674791859785902 1.0894837571172664 0.9983475689124459 1.0391963459856164 1.1365985420537963 1.0 12.333089203699323 ESSIIAPAPAEDVDT(ph)PPRK ddPTM_A459_Selumetinib_30min_R2 2 ESSIIAPAPAEDVDTPPRK 19 1 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 ESSIIAPAPAEDVDT(1)PPRK;ESSIIAPAPAEDVDT(1)PPRK 123.84 0.00051149 27844000.0 416120.0 413590.0 398110.0 405890.0 404270.0 313540.0 396120.0 401980.0 273851.0 350740.0 True False 392993.7162603419 445311.0230985441 372496.0360293935 350607.0818006963 353481.9883803447 356727.28896726295 414540.3648968894 403149.69524862885 328628.8520362532 340613.2248680392 1.1537829055598063 1.3073803087683018 1.0936041493212907 1.0293407777590813 1.0377811622472708 1.0473089795778385 1.217041308532548 1.1835996544315555 0.9648153038202525 1.0 18.377774925545857 -5.358626117936461 7.040298964182031 1.0790771415812446 1.2297934770834158 0.3765807849215741 0.08145303916791591 0.261876598145473 16.217335473033696 0.022015910701357843 0.04625007636455937 4.3789892804661925e-06 5.358626117936461 0.15071633550217123 ESSKELESPLT(ph)PGK ddPTM_A459_Selumetinib_30min_R1 2 ESSKELESPLTPGK 14 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 ESSKELES(0.008)PLT(0.992)PGK;ESSKELES(0.002)PLT(0.998)PGK 152.94 0.0038642 17428100.0 5373.16 5763.44 8685.7 8379.7 5806.53 5817.969999999999 5586.69 5614.0199999999995 4036.56 5434.46 True False 5498.3441736506475 5088.653765449433 7506.229647134963 6916.342701450546 5281.330386726132 5759.446504094106 5165.281475430078 5465.117952693019 6849.747501322208 6132.025877123097 0.8966603018039206 0.8298487102661783 1.2241027349768112 1.1279050088900504 0.8612700749403756 0.9392404108373087 0.8423450224990607 0.8912418281015205 1.1170447807268284 1.0 12.582148069838555 -6.276918972639169 24.85402661023867 0.931312686721378 1.0206787055817352 0.08038873951708936 0.12584894620782727 1959.1220321888425 3145557.6897404706 0.041676718932245345 0.04741373087050316 5.285438542684306e-07 6.276918972639169 0.08936601886035722 ESSNPS(ph)DRWR ddPTM_A459_Selumetinib_30min_R1 1 ESSNPSDRWR 10 1 Q9Y388 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 ESS(0.378)NPS(0.621)DRWR 140.78 0.0065539000000000005 28774000.0 7097.1 5661.3 9317.0 10870.0 8664.3 6820.9 7295.7 6244.4 4308.3 5409.7 True False 7262.448621447347 4998.472364133035 8051.802574617648 8971.758555171124 7880.615594806404 6752.287938881686 6745.379475198231 6078.778227330196 7310.870434217867 6104.087689940279 1.189768068603615 0.818872961535377 1.3190836999093676 1.469795162011983 1.2910390536810106 1.1061911757935032 1.105059399181768 0.995853686268008 1.197700754900098 1.0 12.575559972413375 -6.9107063607632 6.610965142370447 1.078621806849619 1.2148623203671038 0.15070203701488483 0.16341966394252633 0.5038097065890684 30.945189713716513 0.06389324913490785 0.05629693740545573 1.2282694194483165e-07 6.9107063607632 0.1362405135174849 ESSPIPS(ph)PTSDR ddPTM_A459_Selumetinib_30min_R1 1 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ESS(0.005)PIPS(0.968)PT(0.027)SDR 137.62 0.0013085 9536400.0 5713.2 7028.4 6815.2 7301.5 6768.7 6069.3 6297.4 6293.2 3857.7 5719.9 True False 5846.306444047991 6205.511660585483 5889.733273213925 6026.430091129896 6156.472280111048 6008.248352483483 5822.382047934176 6126.283892805455 6546.2351447397505 6454.104881544149 0.9058276168963121 0.9614829282261075 0.9125561764662247 0.9337360023948152 0.9538847590958435 0.9309189210210055 0.9021207672939406 0.949207365737716 1.0142746771065114 1.0 12.656001306994872 -8.159563058062366 4.125083348101926 1.0070152590985484 0.9303118658476389 0.7348530347849673 0.018511180894128454 0.11151087334398033 3.179349259797632 0.01372265625851254 0.00467014683106334 6.925273695491813e-09 8.159563058062366 -0.07670339325090947 ESSPIPS(ph)PTSDR ddPTM_A459_Selumetinib_30min_R2 1 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ESS(0.001)PIPS(0.899)PT(0.099)S(0.001)DR 123.28 0.0027555999999999995 0.0 37831.0 29468.0 43720.0 41087.0 53931.0 29432.0 29464.0 36920.0 32728.0 39526.0 True False 35728.50446949199 31728.1008454458 40907.10279873683 35490.87972097163 47155.70563074274 33485.990842905194 30834.134381808402 37027.431087565 39274.514496724536 38384.78167911871 0.930798689130705 0.8265802085493132 1.0657114879720746 0.9246080912394153 1.2285000348561421 0.8723767435447353 0.8032906019778705 0.9646383141396866 1.0231793116616799 1.0 15.228246822063792 -5.2493924091739945 24.840256805490608 0.9800116999885554 0.8786894552536417 0.1274875882802443 0.11086305409287042 1596.2175910529272 3291305.67878672 0.029283769214581156 0.07620234252749129 5.631286079250646e-06 5.2493924091739945 -0.10132224473491369 ESSPIPS(ph)PTSDRK ddPTM_A459_Selumetinib_30min_R1 1 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ESSPIPS(0.814)PT(0.144)S(0.042)DRK 168.0 0.00052325 16911000.0 3375.8 3431.6 3520.6 4025.8 3225.0 2984.3 3291.6 3098.0 1860.6 2294.8 True False 3454.449571836658 3029.8266766924394 3042.521857271535 3322.769603625381 2933.2993194199958 2954.2806515276 3043.311961917636 3015.8309762777776 3157.302307152648 2589.359933244904 1.3340940081310562 1.1701064181121998 1.1750092438708368 1.283239753950078 1.1328279555728191 1.1409308584710312 1.175314378987804 1.1647013370205483 1.2193369745997487 1.0 11.338379805255476 -14.522878745280336 0.12705856969774088 0.39005403219256807 1.275335299752171 0.5423515995780218 0.05759340614204019 121.54358471998883 0.9786761945069198 19.155602923042924 0.47048012481932666 3.0000000000000132e-15 14.522878745280336 0.8852812675596029 ESSPIPS(ph)PTSDRK ddPTM_A459_Selumetinib_30min_R2 1 ESSPIPSPTSDRK 13 1 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ESSPIPS(0.485)PT(0.394)S(0.121)DRK 112.02 0.013669999999999998 0.0 13440.0 13034.0 14100.0 12648.0 14455.0 10003.0 11557.0 11018.0 9474.3 12019.0 True False 12693.05860458282 14033.665889084446 13192.821350919248 10925.320580983014 12639.0336706604 11380.822451806891 12094.42339976105 11050.060555871909 11369.424734060038 11671.980240887713 1.087481159376727 1.2023380437128905 1.130298465097116 0.9360297357864691 1.0828525588473012 0.9750549792689952 1.0361929295762078 0.9467168661888941 0.9740784767808461 1.0 13.510761725628871 -5.676657065578424 6.740802833370697 0.9957994516704864 1.1491231724021735 0.66424863176523 0.047853498684114995 0.11976110123595002 7.83325489408759 0.012486886616181142 0.021711293058626163 2.1054403143514345e-06 5.676657065578424 0.1533237207316871 ESSPIPSPT(ph)SDR ddPTM_A459_Selumetinib_30min_R1 1 ESSPIPSPTSDR 12 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 ESS(0.002)PIPS(0.24)PT(0.748)S(0.01)DR 105.66 0.021583 10016000.0 2459.8 2070.0 2063.3 1904.7 2576.8 1975.0 2334.0 1869.3 1258.8 1787.0 True False 2517.108554062389 1827.6434376831082 1783.115192895631 1572.0799006471423 2343.72889497099 1955.1332931565225 2157.9445008858206 1819.720091657859 2136.0916608856023 2016.3788568540353 1.248331158356617 0.9063988304928999 0.884315557482911 0.7796550213286353 1.1623455021878617 0.9696259641439265 1.0702078597732654 0.9024693377796054 1.0593701940608242 1.0 10.97755101653236 -6.273868602843483 24.998818873652283 1.0217179715493898 0.9462011370164978 0.06867100327009257 0.1286020096706075 2281.528179795028 4588816.078238713 0.040041168295619614 0.04572579984675203 5.322692746448125e-07 6.273868602843483 -0.07551683453289204 ESSPLYSPT(ph)FSDSTSAVK ddPTM_A459_Selumetinib_30min_R2 1 ESSPLYSPTFSDSTSAVK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ESSPLY(0.013)S(0.167)PT(0.54)FS(0.075)DS(0.188)T(0.014)S(0.002)AVK 112.43 0.0028918000000000004 4445700.0 9233.3 10823.0 9659.7 10047.0 9675.9 8671.8 8785.6 9812.0 5444.9 9890.5 True False 8720.150149828462 11653.089298569963 9038.205418686144 8678.58126795829 8460.326938356484 9866.261735237335 9194.147808336133 9840.55129553595 6534.032143217284 9604.935566394865 0.907882212176203 1.213239715979048 0.9409959448669745 0.9035543453641018 0.8808312018205449 1.0272074879665807 0.9572315966911876 1.0245306933620089 0.6802786023966823 1.0 13.229560220431662 -5.481934723204068 24.79014415794167 0.929048155882342 1.0647002706603403 0.17407267344902444 0.11666088034164035 712.4292955802439 431348.93802031945 0.028899232254945496 0.06014649705309662 3.296592580129952e-06 5.481934723204068 0.13565211477799832 ESSPTS(ph)PVAETEGTIMEESSR ddPTM_A459_Selumetinib_30min_R1 1 ESSPTSPVAETEGTIMEESSR 21 0 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 ES(0.001)S(0.005)PT(0.209)S(0.785)PVAETEGTIMEESSR 109.65 0.00052502 0.0 288.67 293.89 253.92 429.49 266.95 349.6 311.13 280.57 193.92 225.07 True False 295.3954493459591 259.4812221742456 219.43905868272103 354.48763402579976 242.80441963385027 346.0833414114026 287.66121360779994 273.1283721801987 329.06807664357825 253.95992686745254 1.1631577193677989 1.0217408131073953 0.8640696246429904 1.3958408257489179 0.9560737500155898 1.3627478385282075 1.1327031676061903 1.0754782281960202 1.2957480367181171 1.0 7.988457057360233 -5.745170023316415 24.999964170105706 1.1742824987475204 1.0168646377067818 0.18282276153547772 0.15284424994250911 404.16566159218087 621047.6384595735 0.03904364114641686 0.06735874416390618 1.7981668073165612e-06 5.745170023316415 -0.15741786104073863 ESSS(ph)IYISK ddPTM_A459_Selumetinib_30min_R1 2 ESSSIYISK 9 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 1 ESS(0.023)S(0.976)IYISK;ES(0.074)S(0.038)S(0.876)IYIS(0.012)K 160.91 6.0517999999999985e-06 8722500.0 4334.7 7239.9 7217.799999999999 8581.7 7425.1 6168.200000000001 7164.2 6932.4 2775.1 5090.5 True False 4435.690076142062 6392.249142261803 6237.662404537427 7083.067193460168 6753.501016007882 6106.1535082775 6623.798626069486 6748.530232391243 4709.142014715315 5743.915260668977 0.7722415590834204 1.1128731626722008 1.085960032740968 1.2331427035424656 1.1757661298125281 1.063064692142818 1.1531852970438898 1.1749007299256817 0.8198487966841723 1.0 12.487818750063576 -10.768839373733538 14.480561691550665 1.0000202735828332 1.081524766436029 0.007597369971030887 0.14532629473419115 0.0 0.0 0.13837397142022698 0.033560617647164434 1.7027881777670644e-11 10.768839373733538 0.08150449285319583 ESSTESSQSAKPVSGQDTSGNTEGS(ph)PAAEK ddPTM_A459_Selumetinib_30min_R2 2 ESSTESSQSAKPVSGQDTSGNTEGSPAAEK 30 1 Q96S66-4;Q96S66-3;Q96S66-2;Q96S66 Q96S66-4 CLCC1 Chloride channel CLIC-like protein 1 1 ESSTESSQSAKPVS(0.004)GQDT(0.043)S(0.043)GNT(0.138)EGS(0.771)PAAEK;ESSTESSQSAKPVS(0.014)GQDT(0.073)S(0.073)GNT(0.212)EGS(0.628)PAAEK 85.06299999999997 1.3683e-06 9312500.0 22969.0 7677.299999999999 17484.1 20114.1 11501.3 14005.1 28357.0 21349.6 16728.6 14322.0 True False 21692.474932192166 8266.124223589684 16359.19204124874 17374.524881242127 10056.403871073438 15934.175399360263 29675.656688329524 21411.723801383454 20074.78743613742 13908.486646975109 1.55965745826919 0.5943223323572335 1.1762021603411916 1.24920311765341 0.72304084019526 1.1456440807545163 2.1336366379431757 1.5394718595096173 1.443348075579696 1.0 13.763677831372066 -7.024818240234261 24.84156055464252 1.5834373851425672 1.0397844841265005 0.27340415600896995 0.36002406900056644 783.8209462988555 784555.1631663719 0.13060570134403665 0.10167821131113577 9.444560648113381e-08 7.024818240234261 -0.5436529010160667 ESSTSEGADQKMS(ph)SPEDDSDTKR ddPTM_A459_Selumetinib_30min_R1 2 ESSTSEGADQKMSSPEDDSDTKR 23 2 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 ESSTS(0.001)EGADQKMS(0.977)S(0.021)PEDDSDTKR;ESSTSEGADQKMS(0.935)S(0.065)PEDDSDTKR 103.45 3.271e-05 12416100.0 2252.81 2425.85 3529.4 3763.7 2807.75 2962.9500000000003 2510.48 2757.12 1524.08 2152.36 True False 2305.2960897948155 2141.830354252931 3050.1268656064735 3106.4404483990397 2553.7895082485234 2933.1454131433497 2321.1124724009564 2683.992221212066 2586.2524456009924 2428.636371761807 0.9492141831518744 0.8819065625288244 1.2559010072775194 1.2790883330737293 1.0515322663952062 1.2077334619737892 0.95572663713224 1.105143714563171 1.064899000802185 1.0 11.245930782899638 -10.449736473627818 14.771978828613031 1.0000000009426449 1.087954962676063 0.03655710670112544 0.12666003656518277 0.0 0.0 0.1292344973513301 0.03134396959136117 3.550287524565462e-11 10.449736473627818 0.0879549617334181 ESSTSEGADQKMSS(ph)PEDDSDTKR ddPTM_A459_Selumetinib_30min_R1 1 ESSTSEGADQKMSSPEDDSDTKR 23 2 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 ESSTSEGADQKMS(0.033)S(0.967)PEDDSDTKR 122.83 1.1846e-05 9882900.0 1879.3 1760.3 2388.1 2629.4 1671.2 1928.3 1665.1 1972.5 1202.9 1664.5 True False 1923.0840335187606 1554.2032576587326 2063.8091368943215 2170.224649950962 1520.0402550743245 1908.903052756316 1539.5001664202987 1920.1828924170168 2041.2334436600681 1878.154788602989 1.0239220138768175 0.8275160636865195 1.0988493330890081 1.1555089405411685 0.8093264007302414 1.0163715282360717 0.8196875868604053 1.0223773376236414 1.086829187906488 1.0 10.875100252631132 -7.98520792008956 24.970493673611756 1.0471442465374046 0.9643993911254275 0.07983770814258961 0.11329931639493383 565.2650330593274 954222.8874083966 0.06241082638537331 0.02996403257930526 1.0346467071493136e-08 7.98520792008956 -0.08274485541197707 EST(ph)GNMVTGQTVCK ddPTM_A459_Selumetinib_30min_R2 1 ESTGNMVTGQTVCK 14 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 ES(0.302)T(0.695)GNMVT(0.002)GQT(0.001)VCK 95.236 0.029559 10421000.0 54710.0 49506.0 51657.0 58754.0 59340.0 48607.0 56012.0 53365.0 36866.0 57516.0 True False 51669.43722148255 53302.95101312062 48333.44485988904 50751.603843696736 51885.17869366921 55302.17303958589 58616.66898567242 53520.283314948676 44240.230122104804 55855.363635485315 0.9250577537849307 0.9543031777749786 0.865332202925315 0.9086254307626399 0.9289202561149594 0.9900960165704126 1.049436708857676 0.958194161338283 0.7920498094116546 1.0 15.769408204909253 -6.5640072376496175 7.596866322160744 0.9610473898718601 0.9135251880554642 0.09405283926834052 0.06548735603216094 0.5602313369869745 86.17767729163072 0.022608829529548412 0.022696299124830666 2.7289323039423213e-07 6.5640072376496175 -0.04752220181639588 ESTESSNT(ph)TIEDEDVK ddPTM_A459_Selumetinib_30min_R1 1 ESTESSNTTIEDEDVK 16 0 H0Y9J2;D6R938;Q13557-8;Q13557-12;Q13557;E9PBG7;E9PF82;Q13557-10;Q13557-6;Q13557-11 H0Y9J2 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1 ESTESSNT(0.744)T(0.256)IEDEDVK 218.34 2.6310000000000005e-10 22302000.0 3411.4 4786.8 3309.4 3679.2 3127.7 3778.7 3498.2 4272.6 2394.2 4019.6 True False 3490.878982571119 4226.359230677054 2860.0016572329764 3036.696787137589 2844.8000872402836 3740.6897087850884 3234.327957583022 4159.276768639261 4062.7825345506144 4535.554814219631 0.7696696712002467 0.9318284981204056 0.6305737168618161 0.6695314931741313 0.6272220717786096 0.8247479882852427 0.7131052517418439 0.9170381439552481 0.8957630766170422 1.0 12.147063324669446 -7.952362475846743 1.5055912087871435 0.9732183953844147 0.7337656170953188 0.4906387750820135 0.09163909252193322 0.37380743217008666 1.5269844110793658 0.08412583347866735 0.028845637060394887 1.1159314674543648e-08 7.952362475846743 -0.23945277828909584 ESTESSNT(ph)TIEDEDVK ddPTM_A459_Selumetinib_30min_R2 2 ESTESSNTTIEDEDVK 16 0 H0Y9J2;D6R938;Q13557-8;Q13557-12;Q13557;E9PBG7;E9PF82;Q13557-10;Q13557-6;Q13557-11 H0Y9J2 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1 ESTESS(0.004)NT(0.498)T(0.498)IEDEDVK;ESTESSNT(0.761)T(0.239)IEDEDVK 276.3 2.4470999999999996e-51 67867000.0 260888.0 185863.0 215863.0 206284.0 199000.0 163189.0 196707.0 205434.0 154518.0 160581.0 True False 246388.88937741108 200118.09445626035 201974.60959386357 178187.7633402514 173999.84091742776 185666.80346775113 205854.26526752586 206031.7789285706 185425.91759364677 155944.60929045585 1.5799769578344163 1.2832639445941272 1.2951689097355985 1.142634966036988 1.115779774043635 1.190594559905152 1.320047330934732 1.3211856431973517 1.1890498712160051 1.0 17.250674156777954 -4.226362151833305 1.2885892887286867 1.2038409404626642 2.48836959062377 0.6042455565776079 0.09350059447174532 3.6345765992036223 1.9503862096566478 0.02801793285779531 8.753410557836638 5.937967936211068e-05 4.226362151833305 1.2845286501611057 ESTESSNT(ph)TIEDEDVKAR ddPTM_A459_Selumetinib_30min_R2 2 ESTESSNTTIEDEDVKAR 18 1 H0Y9J2;D6R938;Q13557-8;Q13557-12;Q13557;E9PBG7;E9PF82;Q13557-10;Q13557-6;Q13557-11 H0Y9J2 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1 ESTESS(0.004)NT(0.498)T(0.498)IEDEDVKAR;ESTES(0.001)S(0.005)NT(0.496)T(0.496)IEDEDVKAR 113.71 0.0015862 13057600.0 34412.0 39787.0 45302.0 51168.0 45713.0 23523.0 16585.9 18876.2 16714.2 42931.0 True False 32499.518802150575 42838.53496463115 42387.31864108819 44198.83013027667 39970.124260594865 26763.079729466524 17357.17721433735 18931.126616876874 20057.5070337678 41691.47048186625 0.7795244069476099 1.027513169228795 1.0166904201549956 1.060140830232913 0.9587122689275235 0.6419317769352164 0.4163244187294107 0.45407673075745764 0.48109377774266404 1.0 15.347464637267429 -6.818705046681801 3.7243418448717303 0.5411715461210328 0.9828594950181844 0.5364653969890704 0.16991765475263565 0.15251954644259438 4.28806663224719 0.059058097564958015 0.053188697718199715 1.518081029924232e-07 6.818705046681801 0.44168794889715157 ESTESSNTT(ph)IEDEDVK ddPTM_A459_Selumetinib_30min_R1 1 ESTESSNTTIEDEDVK 16 0 H0Y9J2;D6R938;Q13557-8;Q13557-12;Q13557;E9PBG7;E9PF82;Q13557-10;Q13557-6;Q13557-11 H0Y9J2 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1 ESTESSNT(0.182)T(0.818)IEDEDVK 283.1 1.9102999999999998e-62 21919000.0 5067.8 5215.0 4429.4 4755.3 3995.7 4493.6 4662.7 4400.2 2827.2 4823.1 True False 5185.869879777779 4604.425375612273 3827.9118089526028 3924.8761230363607 3634.2896404981325 4448.398463862353 4310.988785038691 4283.492402136045 4797.551909481871 5442.191865972408 0.9529009648121199 0.8460608315560657 0.7033768568298416 0.7211940004498658 0.6677988814069052 0.8173909655181766 0.7921420066046139 0.7870895601676242 0.8815477343749708 1.0 12.409972104757111 -8.556619098261244 1.743959162676226 1.0000865004619566 0.778285356524802 0.43654381452270796 0.07611908121487758 0.4034449033256756 2.7485166750005328 0.07833026057245018 0.022375755501046996 2.7757535360570448e-09 8.556619098261244 -0.22180114393715455 ESTESSNTT(ph)IEDEDVKAR ddPTM_A459_Selumetinib_30min_R1 2 ESTESSNTTIEDEDVKAR 18 1 H0Y9J2;D6R938;Q13557-8;Q13557-12;Q13557;E9PBG7;E9PF82;Q13557-10;Q13557-6;Q13557-11 H0Y9J2 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1 ESTESSNT(0.005)T(0.995)IEDEDVKAR;ESTESSNT(0.047)T(0.953)IEDEDVKAR 196.36 3.7086e-10 29456000.0 3315.6000000000004 3832.3 5721.9 6524.8 5012.5 4904.799999999999 4601.200000000001 3625.6 2098.3 2913.9 True False 3392.8470289654665 3383.6125344120637 4944.897408146905 5385.366165665183 4559.1202600287515 4855.462165202081 4254.127779552628 3529.4373103914486 3560.6618462315423 3287.9274487895746 1.0319105521061656 1.0291019455607864 1.5039557548532074 1.6379212283554994 1.386624349544926 1.4767546549695258 1.2938630325066185 1.0734535251654607 1.0829502480483177 1.0 11.682962749610425 -7.724078816578219 3.73786119661037 1.0517225810953441 1.3547998863818673 0.3411296733776482 0.18238890818788617 0.2926788943240604 8.522764992705188 0.11263457295206576 0.05693881742946098 1.887648743969698e-08 7.724078816578219 0.3030773052865232 ESTESSNTT(ph)IEDEDVKAR ddPTM_A459_Selumetinib_30min_R2 2 ESTESSNTTIEDEDVKAR 18 1 H0Y9J2;D6R938;Q13557-8;Q13557-12;Q13557;E9PBG7;E9PF82;Q13557-10;Q13557-6;Q13557-11 H0Y9J2 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta 1 ESTES(0.003)S(0.004)NT(0.255)T(0.737)IEDEDVKAR;ESTESSNT(0.064)T(0.936)IEDEDVKAR 120.66 0.001313 14107600.0 31563.0 42743.0 38254.0 44590.0 40706.0 29988.0 16481.8 19425.6 19074.4 41328.0 True False 29808.854816699968 46021.25065959307 35792.77928780599 38516.7650779596 35592.14836374282 34118.57479603972 17248.236358067115 19482.125279918793 22889.81298326576 40134.753256960415 0.742719274386727 1.146668334172748 0.8918151074368095 0.9596861062371123 0.8868161748962592 0.8501005245403538 0.4297581262711717 0.48541784112102604 0.5703239991713682 1.0 15.292564407687133 -7.096967549206365 4.89894087302799 0.5800051847503002 0.9323752040639621 0.4048957345080527 0.17182193340005203 0.19025048315468554 7.343938182472361 0.0634313707852573 0.04911594799908992 7.998940214262549e-08 7.096967549206365 0.35237001931366196 ESTHQSEDVFLPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ESTHQSEDVFLPSPR 15 0 Q13017-2;Q13017;A0A0A0MSK6 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 ESTHQSEDVFLPS(1)PR;ESTHQSEDVFLPS(1)PR 159.26 9.2036e-05 3190700.0 1829.6599999999999 2970.71 2544.89 2669.18 5780.6 2312.99 4565.2 2445.2200000000003 716.8199999999999 1183.42 True False 1872.2875181013876 2622.897892154389 2199.3079160801435 2203.0578197140417 5257.74575064782 2289.7234206268886 4220.843288536394 2380.364822406052 1216.3911855386232 1335.3234844869623 1.40212281132817 1.9642415659020023 1.6470225691605567 1.6498308052752229 3.937432248986373 1.714733131879734 3.160914443257966 1.7826128650171982 0.9109337173126754 1.0 10.382973564351998 -8.12873063124588 4.1132147270872625 0.9694944078604272 2.219698447050341 0.3062894227890579 0.7427750452574259 0.2906411809483599 7.978445654864126 0.563821375840549 0.1951070638274803 7.434801343643266e-09 8.12873063124588 1.2502040391899136 ESTHQSEDVFLPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 ESTHQSEDVFLPSPR 15 0 Q13017-2;Q13017;A0A0A0MSK6 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 ESTHQSEDVFLPS(1)PR;ESTHQSEDVFLPS(1)PR 167.05 4.9919e-05 3507700.0 13163.2 8523.8 24718.0 36036.0 39072.0 21182.0 16175.5 19064.6 21005.0 30676.0 True False 12431.64204046462 9177.548051663187 23127.670790923527 31127.834634432664 34163.42605188816 24099.628228948684 16927.692801145182 19120.074829685567 25206.58692873681 29790.304174180186 0.41730497170416125 0.3080716463317464 0.7763489307023831 1.0448981807111504 1.1467968185936899 0.8089755676223099 0.5682282632017142 0.6418220746553267 0.8461339226802468 1.0 14.862555233863343 -5.320329996670217 5.012527917318296 0.8505340715973971 0.36179027655805446 0.5805803494612065 0.16772313418607895 0.15492399558655318 8.17187622949953 0.05074771407107872 0.11236572682160602 4.782665455793407e-06 5.320329996670217 -0.4887437950393427 ESTNLGNLEES(ph)SE ddPTM_A459_Selumetinib_30min_R2 1 ESTNLGNLEESSE 13 0 P24386 P24386 CHM Rab proteins geranylgeranyltransferase component A 1 1 ESTNLGNLEES(0.969)S(0.031)E 143.55 0.0010758 0.0 20824.0 18621.0 24554.0 25552.0 26420.0 16178.0 17991.0 20562.0 14762.0 20412.0 True False 19666.68544507683 20049.170824047993 22974.222372373843 22071.773520341412 23100.883402203242 18406.372650737976 18827.617148490182 20621.832015777647 17714.812484742346 19822.652523254856 0.9921318764986142 1.0114272446902552 1.1589883011580684 1.1134621612545552 1.1653780126096922 0.9285524542764709 0.9498031167323671 1.040316475889654 0.8936650866457096 1.0 14.274862405953675 -6.77307176901639 24.999682985612683 0.9641956748915088 1.0893355886312301 0.4955337242957518 0.06345298902985276 205.1075535188458 440803.1702354694 0.023430578251879983 0.020831419007386647 1.6862743383320514e-07 6.77307176901639 0.12513991373972133 ESTPGDS(ph)PSTVNK ddPTM_A459_Selumetinib_30min_R1 1 ESTPGDSPSTVNK 13 0 Q5T6F2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 ESTPGDS(0.999)PS(0.001)TVNK 241.42 4.9675e-65 0.0 2706.6 2869.2 2930.9 2900.1 2474.1 2187.6 2256.7 2141.4 1418.4 2584.4 True False 2769.658513873187 2533.272730145109 2532.8998782812996 2393.6519766192964 2250.3180918378316 2165.5947301818787 2086.475302120407 2084.603115752495 2406.9212041628057 2916.132914187783 0.9497710136592341 0.8687096249351479 0.8685817666122315 0.8208308904486231 0.7716788493725438 0.7426255228784905 0.7154938967181964 0.7148518867608302 0.8253811725976126 1.0 11.509840762306885 -5.544752685026918 1.2003886793450762 0.7744040518786847 0.9298814194019642 0.23297365387668545 0.08012264614654688 0.703731070044011 1.8089358308806693 0.026093252686043747 0.09781698229357312 2.852642281480371e-06 5.544752685026918 0.15547736752327956 ESTPSEEPS(ph)PPHNSK ddPTM_A459_Selumetinib_30min_R1 2 ESTPSEEPSPPHNSK 15 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 ESTPSEEPS(1)PPHNSK;ESTPSEEPS(0.999)PPHNS(0.001)K 121.51 0.0011023 21232600.0 10615.5 11759.6 9899.3 12003.900000000001 22759.0 11475.8 17953.5 11395.3 3101.3 5684.1 True False 10862.820495832704 10382.780565110275 8555.029432962587 9907.644206110266 20700.452468427804 11360.363871192725 16599.25304055423 11093.059626848988 5262.679590009948 6413.70960282262 1.693687611152845 1.6188417013051075 1.3338660405200744 1.5447603367869969 3.2275319199543597 1.771262588220883 2.5880892757054417 1.7295855774273012 0.8205359949090753 1.0 12.64694331819653 -8.178173718721395 4.462001810067398 0.91019733964143 1.9657090860370285 0.37957476675976276 0.531048885638683 0.23828731405420994 8.272772138314432 0.421440702603072 0.14470445766279558 6.634776248474288e-09 8.178173718721395 1.0555117463955985 ESTPSEEPS(ph)PPHNSK ddPTM_A459_Selumetinib_30min_R2 1 ESTPSEEPSPPHNSK 15 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 ESTPSEEPS(0.999)PPHNS(0.001)K 79.92 0.019955 12488000.0 42230.0 39215.0 76704.0 105160.0 127540.0 84007.0 43577.0 64476.0 85242.0 98822.0 True False 39883.02566008423 42222.66440390104 71768.94814900076 90837.0265888818 111517.28497793352 95578.20171038106 45603.416846187334 64663.61448542361 102292.78186048013 95968.75208960834 0.41558345598622026 0.43996262829881044 0.7478366300104471 0.9465271206617866 1.1620166205121343 0.9959304422457987 0.47519026613585974 0.6737986383843527 1.0658967594469384 1.0 16.550277113050974 -5.357551361604149 2.9580402446272163 0.8848477907900052 0.4147760523407351 0.4977659823518106 0.1878444103694906 0.2472632018175496 4.118685707818008 0.056994571596373333 0.14677205098951124 4.389839463697517e-06 5.357551361604149 -0.4700717384492701 ESTQLS(ph)PADLTEGKPTDPSK ddPTM_A459_Selumetinib_30min_R1 4 ESTQLSPADLTEGKPTDPSK 20 1 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 ES(0.027)T(0.022)QLS(0.947)PADLT(0.004)EGKPTDPSK;ES(0.068)T(0.272)QLS(0.66)PADLTEGKPTDPSK;ES(0.255)T(0.199)QLS(0.546)PADLTEGKPTDPSK;ES(0.133)T(0.114)QLS(0.724)PADLT(0.028)EGKPTDPSK 129.08 0.0001006 128531000.0 18770.7 21530.0 14175.0 13063.1 14666.2 14364.7 19378.9 19812.700000000004 10558.050000000001 19671.0 True False 19208.020788575854 19009.25759097456 12250.112857701522 10781.87480975675 13339.64479952792 14220.204160104056 17917.133970958115 19287.202835280426 17916.239720538004 22195.964461765932 0.8653834719217984 0.8564285468973114 0.5519072117277526 0.48575833811273517 0.6009941501981755 0.640666197884725 0.807224844940692 0.8689508792692452 0.8071845560664846 1.0 14.438009777736053 -7.430079499542751 3.0067745714855327 0.8767942317856969 0.6589239115465221 0.4129677034463958 0.1213933972813495 0.31523129774468817 5.493754443571649 0.0661965035010136 0.04018292010042503 3.714672241401769e-08 7.430079499542751 -0.21787032023917485 ESTQLS(ph)PADLTEGKPTDPSK ddPTM_A459_Selumetinib_30min_R2 3 ESTQLSPADLTEGKPTDPSK 20 1 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 ES(0.11)T(0.092)QLS(0.797)PADLT(0.002)EGKPTDPSK;ES(0.075)T(0.06)QLS(0.863)PADLT(0.001)EGKPTDPSK;ES(0.004)T(0.019)QLS(0.961)PADLT(0.016)EGKPTDPSK 110.89 0.00020058 162458100.0 704337.0 503500.0 623475.0 701932.0 684386.0 672659.0 821233.0 789117.0 666972.0 537768.0 True False 665192.7692244081 542116.8309923281 583361.2972882526 606327.6506997615 598407.3121915312 765311.6714595591 859421.9617423178 791413.1998246487 800385.0367547475 522241.2405509355 1.273727001189463 1.0380582552623094 1.1170341443598726 1.1610106663734934 1.1458446130379223 1.4654370663109597 1.6456416977634232 1.515416896202513 1.5325963838290246 1.0 18.994356863893472 -6.764262535099011 6.660243264410373 1.4785578611354326 1.1392668988221324 0.397374474378247 0.1704477908353843 0.1191363690302912 24.60669223846259 0.05537248080557337 0.0517051347405618 1.7208280037868433e-07 6.764262535099011 -0.33929096231330025 ESTQLSPADLT(ph)EGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSK ddPTM_A459_Selumetinib_30min_R2 1 ESTQLSPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSK 47 2 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 ES(0.021)T(0.02)QLS(0.062)PADLT(0.239)EGKPT(0.094)DPS(0.094)KLES(0.094)PS(0.094)FT(0.094)GT(0.094)GDT(0.094)EIAHAT(0.001)EDLENNGSK 45.832 0.0012458 17012000.0 13854.0 13326.0 15935.0 20007.0 18127.0 16382.0 13417.0 15211.0 13251.0 17025.0 True False 13084.050141956128 14348.061350156462 14909.759448716188 17282.01208599994 15849.724202563893 18638.471799010345 14040.917085281135 15255.261491683383 15901.570263874864 16533.444013737684 0.791368702799281 0.867820481820643 0.9017939297056092 1.045275991598621 0.9586462560005232 1.1273193766237444 0.8492433320979282 0.9226910907980058 0.9617820854906096 1.0 14.013099657355928 -5.25106407095532 1.967336950425911 0.976483518784017 0.8034296421750802 0.42431973919808275 0.0711043895709292 0.39234145164831313 2.7052145087698363 0.020644822010078882 0.0853991118536264 5.609652113881277e-06 5.25106407095532 -0.17305387660893679 ESTSSKS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 ESTSSKSPPR 10 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 EST(0.006)S(0.201)S(0.021)KS(0.772)PPR;EST(0.001)S(0.001)S(0.003)KS(0.995)PPR 139.76 0.0070836 267298000.0 4587.67 6378.0 5925.799999999999 5512.2 5878.4 5602.8 4805.0 5473.700000000001 5538.150000000001 4291.5599999999995 True False 4694.553784948128 5631.260794948245 5121.108908089432 4549.597746809037 5346.6997579158115 5546.4409189353755 4442.554981472308 5328.519694916617 9397.836059527806 4842.423529334358 0.9694636903421464 1.162901336662372 1.0575508063404322 0.9395290848164259 1.1041371589095124 1.1453853396623057 0.917423879708222 1.1003828274494358 1.9407298850663808 1.0 12.241513550894602 -8.034508441728523 24.92493652012051 1.487095682842946 1.047017257564528 0.36167923922284584 0.22447448373238796 557.2803155589705 402511.97242546955 0.13615534862662151 0.051524289124726695 9.236162351791e-09 8.034508441728523 -0.440078425278418 ESVAS(ph)GDDR ddPTM_A459_Selumetinib_30min_R2 1 ESVASGDDR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ESVAS(1)GDDR 123.96 0.005462300000000001 13585000.0 49384.0 29787.0 33313.0 45730.0 55497.0 40014.0 88088.0 109610.0 73848.0 54483.0 True False 46639.43497981533 32071.567119699135 31169.67784845195 39501.4951113499 48524.970710525115 45525.56528907338 92184.26654306051 109928.94695308756 88619.66348552052 52909.93422616564 0.8814872984051196 0.6061539782417406 0.589108232779423 0.7465799322769741 0.9171240036531358 0.8604351140274059 1.7422865458311696 2.0776617578693606 1.6749153969217236 1.0 15.691251003840843 -7.222057944239928 4.470629963814117 1.7183004567226308 0.7473533120973478 0.6996944844888318 0.2727014884573029 0.10481179993515394 4.896580849846398 0.10750117862531111 0.07948784037707428 5.997110565428828e-08 7.222057944239928 -0.970947144625283 ESVAS(ph)GDDRAEEDMDEAIEK ddPTM_A459_Selumetinib_30min_R1 4 ESVASGDDRAEEDMDEAIEK 20 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ES(0.008)VAS(0.992)GDDRAEEDMDEAIEK;ES(0.008)VAS(0.992)GDDRAEEDMDEAIEK;ES(0.012)VAS(0.988)GDDRAEEDMDEAIEK;ES(0.006)VAS(0.994)GDDRAEEDMDEAIEK 86.825 0.001218 346453000.0 15971.5 15518.6 10708.8 9258.1 11474.7 10496.1 14401.7 15567.000000000002 9108.2 16145.199999999999 True False 16343.60487487091 13701.675097598592 9254.603779227808 7641.346631060691 10436.815411022824 10390.518763696293 13315.368174124807 15154.112591257637 15455.950163392316 18217.59368756561 0.8971330218011291 0.7521122346114596 0.5080036330783094 0.41944873522326276 0.5728975840616346 0.57035626888464 0.7309070782061184 0.8318394213392217 0.8484078868188695 1.0 14.153044789607016 -7.886730452474572 1.3206374457438719 0.9519728450158403 0.609925684658919 0.48838206340286694 0.1277029148511114 0.4247705379284793 1.3368841676173135 0.12401042519555093 0.04459665969417094 1.2979846231268357e-08 7.886730452474572 -0.3420471603569213 ESVAS(ph)GDDRAEEDMDEAIEK ddPTM_A459_Selumetinib_30min_R2 4 ESVASGDDRAEEDMDEAIEK 20 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ES(0.024)VAS(0.976)GDDRAEEDMDEAIEK;ES(0.033)VAS(0.967)GDDRAEEDMDEAIEK;ES(0.001)VAS(0.999)GDDRAEEDMDEAIEK;ES(0.027)VAS(0.973)GDDRAEEDMDEAIEK 96.777 0.00053668 347662000.0 98550.0 71346.0 93517.0 108697.0 110306.0 93299.0 127798.0 128614.0 114273.0 76767.0 True False 93072.98552690739 76818.00878645226 87500.2180336111 93892.28108721609 96448.3741318482 106150.09036600342 133740.8602269328 128988.24544680597 137130.79305439375 74550.53724538047 1.2484549268982588 1.0304152273726543 1.1737033865444486 1.2594447277847636 1.2937314430664901 1.4238675439268014 1.7939623934127993 1.7302121515535924 1.8394340017032011 1.0 16.185931128818105 -6.822165318429827 1.941303345020988 1.6495713689665332 1.1724011419347076 0.38034146472788566 0.23023757820607077 0.2912361455877888 2.258259404432005 0.09118088996488775 0.08010461286828031 1.5060336706556125e-07 6.822165318429827 -0.47717022703182566 ESVAS(ph)MGADSGDDFASDGSSSR ddPTM_A459_Selumetinib_30min_R1 1 ESVASMGADSGDDFASDGSSSR 22 0 Q5T165;Q92805 Q5T165 GOLGA1 Golgin subfamily A member 1 1 ESVAS(0.618)MGADS(0.382)GDDFASDGSSSR 305.85 1.1660999999999999e-107 8805300.0 1897.7 2270.7 1936.3 1997.8 2245.0 1442.1 1885.7 1683.3 1163.8 1755.5 True False 1941.912717718594 2004.845388380209 1673.3610953345649 1648.921733350585 2041.940146386943 1427.5937833220366 1743.4601308142205 1638.6534158710083 1974.8835994110786 1980.835525018052 0.9803503083381426 1.0121210787361752 0.8447753860428745 0.8324374803079917 1.0308479026133854 0.7207028374094949 0.8801640059430638 0.8272536488641956 0.9969952449197319 1.0 10.951893378371624 -5.254827227073703 24.574029149808577 0.8818191206981507 0.9962357082161565 0.16826047575508307 0.09093728845553509 629.1013757032016 2338029.7440137644 0.022268557661061922 0.055966205010995924 5.561254535240235e-06 5.254827227073703 0.11441658751800576 ESVASMGADS(ph)GDDFASDGSSSR ddPTM_A459_Selumetinib_30min_R1 1 ESVASMGADSGDDFASDGSSSR 22 0 Q5T165;Q92805 Q5T165 GOLGA1 Golgin subfamily A member 1 1 ESVASMGADS(1)GDDFASDGSSSR 197.41 3.0227e-22 9407500.0 2046.3 2058.4 1853.1 1802.6 1982.9 1844.7 1861.6 1747.3 876.28 1892.4 True False 2093.974808593328 1817.4015710758006 1601.4591983496791 1487.8097489927738 1803.5470451094288 1826.1439928535888 1721.1780132172407 1700.9559279697098 1486.983159041021 2135.3079735369774 0.9806429960193591 0.8511191798087145 0.7499897992217872 0.696765884561527 0.84463087641732 0.8552134003549465 0.8060560980186097 0.7965857614216669 0.6963787788315823 1.0 11.060228448115174 -4.8294116316178695 3.264973351495036 0.7977578352617435 0.9963934016193229 0.28058528709378094 0.08333604611482837 0.3524928781312942 6.082752162296961 0.020442870234784718 0.1671546039656706 1.4811135952630722e-05 4.8294116316178695 0.1986355663575794 ESVASMGADS(ph)GDDFASDGSSSR ddPTM_A459_Selumetinib_30min_R2 4 ESVASMGADSGDDFASDGSSSR 22 0 Q5T165;Q92805 Q5T165 GOLGA1 Golgin subfamily A member 1 1 ESVAS(0.006)MGADS(0.993)GDDFAS(0.001)DGSSSR;ESVASMGADS(1)GDDFASDGSSSR;ESVAS(0.002)MGADS(0.998)GDDFASDGSSSR;ESVASMGADS(1)GDDFASDGSSSR 334.98 4.3261999999999975e-162 34182800.0 121271.0 114168.3 123824.0 137848.0 141479.0 106514.7 120151.0 126228.0 107505.1 117074.0 True False 114531.2433062771 122924.64150105586 115857.29864937758 119072.86459893628 123705.14318169227 121186.13308082326 125738.2595746898 126595.3025818297 129009.1239434678 113693.76942521764 1.0073660490393919 1.081190659105641 1.0190294440504324 1.0473121368120066 1.0880556059235913 1.0658995096519668 1.1059379965178695 1.1134761669160602 1.1347070696633368 1.0 16.7947936691627 -6.356866893418992 1.6180891320427686 1.0940942317209876 1.0384166758184958 0.2346930705353607 0.03876484519222784 0.49780776037790325 2.598580067283949 0.0139519240603618 0.017449770437693274 4.396763508551672e-07 6.356866893418992 -0.05567755590249179 ESVFTVEGGHR ddPTM_A459_Selumetinib_30min_R1 2 ESVFTVEGGHR 11 0 F5H3X6;F5GY37;J3KPX7;Q99623-2;Q99623;F5H2D2;F5H0C5;F5GWA7 F5H3X6 PHB2 Prohibitin-2 0 ; 101.93 0.021737 4752400.0 7548.5 9330.099999999999 7524.0 9759.2 7970.5 7982.400000000001 7946.7 7758.799999999999 2829.4 5054.0 False True 7724.365363175842 8237.727554554187 6502.282126373637 8054.938922872672 7249.56968230607 7902.104303439307 7347.274021075121 7553.011419865722 4801.28514880023 5702.730130128875 1.354503051506188 1.4445234767523576 1.1402051259659893 1.4124706481052856 1.2712454415482286 1.385670393499881 1.288378347461636 1.3244553481430539 0.8419274696927884 1.0 12.477437046435645 -8.25434647538297 24.91748716745837 0.9209637229815398 1.3268949777874854 0.7739329616283602 0.08792573183212468 196.64360686402682 690818.4966922288 0.05832753311554599 0.021011920109499448 5.567414095096784e-09 8.25434647538297 0.4059312548059456 ESVGGS(ph)PQTK ddPTM_A459_Selumetinib_30min_R1 2 ESVGGSPQTK 10 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;Q08495-4;E5RFK4;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 ESVGGS(0.999)PQTK;ES(0.148)VGGS(0.852)PQTK 129.74 0.0028969 72019000.0 7453.5 8611.1 8589.0 8599.9 8818.900000000001 7259.0 8352.6 7671.0 5043.799999999999 7517.799999999999 True False 7627.152048013667 7602.90840880822 7422.660975999886 7098.088905116474 8021.232052103253 7185.9810506446565 7722.556657283159 7467.54016108032 8558.960215423269 8482.78285957317 0.8991332413284765 0.8962752595073237 0.875026639120334 0.8367641872508841 0.945589694430403 0.8471254268326556 0.9103800940239719 0.8803172596423229 1.008980231736585 1.0 13.050321917267029 -8.261818724848666 24.998333914047933 1.004490132243536 0.8860998882566964 0.7231777117345171 0.02924272656269266 16.125672107980556 1062447.3678392412 0.02197249442815119 0.007007936371328222 5.472443358144582e-09 8.261818724848666 -0.11839024398683962 ESVGGS(ph)PQTK ddPTM_A459_Selumetinib_30min_R2 2 ESVGGSPQTK 10 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;Q08495-4;E5RFK4;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 ESVGGS(0.976)PQT(0.024)K;ES(0.005)VGGS(0.988)PQT(0.007)K 147.58 0.00081938 95699000.0 321930.0 263340.0 254340.0 301810.0 274560.0 229510.0 292450.0 310240.0 212950.0 269660.0 True False 304038.4193878978 283537.33122844034 237976.0413044536 260702.95734871054 240067.3182024571 261122.91921565562 306049.50447868113 311142.74703700346 255545.95032013766 261874.21513917827 1.1610093770641396 1.0827233642600085 0.9087417834473566 0.9955274031471741 0.9167275902855443 0.9971310809537955 1.1686889612863376 1.188138155838063 0.9758347158551776 1.0 17.998514489367132 -7.2323990120238735 23.91419188104879 1.0988436467057816 1.0040591591382728 0.11886340513765614 0.09241621516620172 722.4828088285576 594951.2076196147 0.03671375999430666 0.028431450986443375 5.8559989202844065e-08 7.2323990120238735 -0.09478448756750879 ESVNS(ph)PVFGK ddPTM_A459_Selumetinib_30min_R1 3 ESVNSPVFGK 10 0 E7ESJ3;Q9UPS8;Q9UPS8-2 E7ESJ3 ANKRD26 Ankyrin repeat domain-containing protein 26 1 ES(0.029)VNS(0.971)PVFGK;ES(0.018)VNS(0.982)PVFGK;ES(0.028)VNS(0.972)PVFGK 153.49 0.00059339 43237700.0 12157.2 14352.2 14770.499999999998 15841.699999999999 14519.0 12048.1 13139.0 12551.9 7400.599999999999 11157.599999999999 True False 12440.43910620672 12671.837751843244 12764.747228548877 13075.244480538577 13205.759013537652 11926.907052799546 12147.914651730407 12218.982837682704 12558.277681561796 12589.786644227524 0.9881374051649017 1.0065172754657714 1.0138970253639343 1.0385596555390109 1.0489263548872414 0.9473478296209323 0.96490234465572 0.9705472525449956 0.9974972599968424 1.0 13.619966213843627 -6.764079477576356 24.999901165656492 0.9735208552889301 1.019282616213596 0.5091288383510586 0.02111043612217235 59.255183681197444 561101.4321342087 0.007720623643611326 0.007119337581064886 1.721553495182846e-07 6.764079477576356 0.045761760924665884 ESVNS(ph)PVFGK ddPTM_A459_Selumetinib_30min_R2 2 ESVNSPVFGK 10 0 E7ESJ3;Q9UPS8;Q9UPS8-2 E7ESJ3 ANKRD26 Ankyrin repeat domain-containing protein 26 1 ESVNS(1)PVFGK;ES(0.001)VNS(0.999)PVFGK 172.76 0.00013466 55308000.0 307910.0 248660.0 278600.0 272810.0 281660.0 190301.0 232827.0 213105.0 168564.0 237050.0 True False 290797.5948613913 267731.4224320799 260675.17931674523 235652.80737650045 246275.35272765203 216513.2353695194 243653.9168379482 213725.10026856788 202281.51007167812 230205.75057013283 1.26320734447856 1.1630092722228274 1.1323573745275741 1.023661688697512 1.0698053898207185 0.9405205336239332 1.0584180292391017 0.9284090416475322 0.8786987708634693 1.0 17.81256434707025 -4.504721250166996 0.4200614044318236 0.9409299417989532 1.5704024752121126 0.8000459893208894 0.04991551545139194 2.8667734737400963 0.33299440684763143 0.037599693744650026 0.9490130510905892 3.1280864702481464e-05 4.504721250166996 0.6294725334131595 ESVPEFPLS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 5 ESVPEFPLSPPK 12 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK 208.51 8.0845e-06 1278760000.0 50573.0 58732.7 42891.4 43427.0 34615.4 43469.1 44799.0 41154.7 29912.499999999996 49212.6 True False 51751.25250207219 51856.248179908514 37066.98346559571 35843.28967575125 31484.44318184523 43031.840320784904 41419.775362118155 40063.14366669434 50759.32777743931 55529.51658131776 0.9319593558191226 0.9338501642449906 0.6675185693596773 0.6454817524525379 0.5669857243532676 0.7749363396270309 0.7459055636017069 0.7214747423206113 0.9140963383520013 1.0 15.760967215983841 -8.41464888932202 3.3325004878877267 0.9976833735790771 0.7431945452707059 0.3757336281332093 0.10971779936841816 0.26494004760984535 5.376789641642226 0.11682989046096864 0.03113708994789114 3.849028356892252e-09 8.41464888932202 -0.25448882830837116 ESVPEFPLS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 5 ESVPEFPLSPPK 12 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK;ESVPEFPLS(1)PPK 198.81 0.00010536 1038433300.0 1401534.0 1296727.0 1263882.0 1301653.0 1208535.0 1102853.0 1354479.0 1197765.0 1023650.0 1178854.0 True False 1323642.3510651325 1396181.7912655247 1182565.2081306775 1124365.6159233323 1056708.0288600174 1254760.9900472453 1417464.9573492224 1201250.29784933 1228408.6031707418 1144817.4219894698 1.1562038851268526 1.2195672117211778 1.0329727565427937 0.9821353119953431 0.9230362925676521 1.096035897031262 1.2381580941404127 1.0492942147594075 1.0730170414737459 1.0 20.126686101800622 -5.264550589082102 24.954191750988358 1.0525931632067367 1.1878855534659456 0.32486192027753946 0.07978557820997911 323.642469626623 2595872.786464195 0.02311261886297452 0.05156726301617441 5.43812781636571e-06 5.264550589082102 0.13529239025920892 ESVPSAS(ph)PTGIPK ddPTM_A459_Selumetinib_30min_R2 2 ESVPSASPTGIPK 13 0 Q5THJ4-2;Q5THJ4;H3BLS7;A0A2R8YD87 Q5THJ4-2 VPS13D Vacuolar protein sorting-associated protein 13D 1 ESVPS(0.044)AS(0.935)PT(0.02)GIPK;ESVPS(0.012)AS(0.968)PT(0.02)GIPK 147.39 0.00057465 8913300.0 111457.0 69425.0 85611.0 91619.0 94033.0 81404.0 96701.0 105691.0 76195.0 88744.0 True False 105262.66613772225 74749.67426344084 80102.88146620922 79140.33414840959 82219.73387431401 92616.66208806243 101197.7881093964 105998.54331191297 91436.12906617974 86181.73013539704 1.221403492043474 0.8673494271466157 0.9294647640557047 0.9182959546539045 0.9540274225771694 1.0746670082226906 1.1742371376207945 1.229942159961078 1.0609688262527068 1.0 16.395094441013555 -6.910954488355537 3.7723292597307174 1.1346907169839833 0.9661423449052405 0.26675795971595884 0.10639575232705531 0.25848039132240747 7.12366675789675 0.038682117523738964 0.033549484632767315 1.2275678666980537e-07 6.910954488355537 -0.16854837207874274 ESVS(ph)PEDSEK ddPTM_A459_Selumetinib_30min_R1 3 ESVSPEDSEK 10 0 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 ES(0.002)VS(0.974)PEDS(0.024)EK;ES(0.005)VS(0.995)PEDS(0.001)EK;ES(0.005)VS(0.988)PEDS(0.007)EK 199.19 9.0085e-05 154986000.0 13516.4 26233.3 23007.5 26669.1 18082.7 20543.3 20394.7 16363.0 9153.599999999999 15224.5 True False 13831.30582166391 23161.89304046969 19883.207871151175 22011.842326008657 16447.122977759976 20336.653053823997 18856.311359132837 15929.000085485246 15532.990647507513 17178.71287418816 0.8051421502274544 1.3482903643655133 1.1574329239198502 1.2813440964533789 0.9574129970163577 1.1838286839511005 1.0976556565809623 0.9272522453890787 0.9041999107422405 1.0 14.068334325246441 -7.70102747949528 4.5116640530611845 0.9356769228619627 1.1340775897881405 0.22731709384484067 0.14680753318081946 0.2746709058115467 11.132101011449858 0.07196862783174078 0.03865445875757874 1.990547385353622e-08 7.70102747949528 0.19840066692617786 ESVS(ph)PEDSEK ddPTM_A459_Selumetinib_30min_R2 3 ESVSPEDSEK 10 0 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 ES(0.026)VS(0.971)PEDS(0.002)EK;ES(0.001)VS(0.993)PEDS(0.006)EK;ES(0.203)VS(0.78)PEDS(0.017)EK 173.72 0.00010538 355413500.0 279820.0 266132.0 269116.0 230392.0 225881.0 184805.0 200193.0 218445.0 155848.0 235831.0 True False 264268.7246082114 286543.4686507463 251801.36955134626 199012.2121516319 197503.80937823866 210260.21125724004 209502.3711749037 219080.63878448328 187021.95475695157 229021.9462674761 1.1539013134556564 1.251161617132056 1.0994639319729906 0.8689656838354012 0.8623794033588937 0.9180788770857614 0.9147698488695255 0.9565923369135012 0.8166114986138818 1.0 17.80512632714416 -5.612066030847349 3.831132444426343 0.902962574923746 1.1988177324418654 0.8409370145434748 0.053472916129616584 0.07438230343611886 2.086231021471212 0.014235660294195403 0.02638353067095502 2.4430590777343725e-06 5.612066030847349 0.2958551575181194 ESVSTASDQPSHS(ph)LER ddPTM_A459_Selumetinib_30min_R1 4 ESVSTASDQPSHSLER 16 0 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 ESVSTASDQPS(0.012)HS(0.988)LER;ESVSTASDQPS(0.002)HS(0.998)LER;ESVSTASDQPS(0.001)HS(0.999)LER;ESVSTASDQPS(0.002)HS(0.998)LER 294.29 5.062199999999998e-75 116636000.0 10558.4 11456.7 12484.3 12578.6 12220.900000000001 11472.5 11754.900000000001 10664.4 5489.299999999999 8993.3 True False 10804.390176929966 10115.344237924668 10789.00063135119 10381.983639565364 11115.521752775134 11357.097066196562 10868.218429075718 10381.545469146784 9314.941177390643 10147.677657160266 1.0647155479269999 0.9968137124248538 1.0631989895479586 1.0230896161980243 1.0953759203153197 1.1191818906647002 1.0710054848270663 1.0230464368191179 0.9179382211473737 1.0 13.308861977319522 -8.040289454121474 4.724259260814328 0.9599666059746101 1.0608814917762581 0.5491683006623531 0.03697096683138587 0.16297813177388742 8.384648601598203 0.02688699328770673 0.010185185041854932 9.11403193266273e-09 8.040289454121474 0.10091488580164798 ESVSTASDQPSHS(ph)LER ddPTM_A459_Selumetinib_30min_R2 4 ESVSTASDQPSHSLER 16 0 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 ESVSTASDQPSHS(1)LER;ESVSTASDQPS(0.002)HS(0.998)LER;ESVSTASDQPSHS(1)LER;ESVSTASDQPS(0.001)HS(0.999)LER 219.23 9.9528e-11 100994000.0 135610.0 123847.0 151572.0 161257.0 153301.0 122311.0 119061.0 116122.0 117799.0 146230.0 True False 128073.33908984189 133345.66666913035 141820.02253911557 139293.51841615874 134041.95785167138 139158.23002128888 124597.5724148959 116459.89579496789 141362.09157906557 142007.95994883173 0.9018743677184662 0.9390013539887301 0.9986765713007646 0.9808852860526195 0.9439045381679262 0.9799326042809877 0.8773985096313676 0.8200941400533511 0.9954518861477984 1.0 17.115612273581206 -7.254570290019016 24.75993163899933 0.9082439786356964 0.9588769052035021 0.057108931370744354 0.055791082319398874 911.4549518320963 3285390.140589261 0.021370818941275443 0.016190889940680717 5.5645456549385423e-08 7.254570290019016 0.050632926567805714 ESVSTEDLSPPS(ph)PPLPK ddPTM_A459_Selumetinib_30min_R1 3 ESVSTEDLSPPSPPLPK 17 0 Q13127-4;Q13127 Q13127-4 REST RE1-silencing transcription factor 1 ESVSTEDLS(0.029)PPS(0.971)PPLPK;ESVSTEDLS(0.047)PPS(0.953)PPLPK;ESVSTEDLS(0.009)PPS(0.991)PPLPK 209.89 1.1282999999999999e-29 9229100.0 6746.6 8039.4 7634.3 7947.200000000001 8560.6 6333.1 6910.0 6359.700000000001 3909.9000000000005 5368.5 True False 6903.782653401624 7098.143310584339 6597.6039922081645 6559.370707420047 7786.295241496682 6269.394763994719 6388.773136727082 6191.020096783018 6634.814732202594 6057.599268618289 1.1396895613691438 1.171774988047929 1.0891450060731813 1.0828333827563028 1.2853764166662516 1.034963602903488 1.0546708115580468 1.022025363885644 1.095287825752126 1.0 12.564530426628409 ESVSTEDLSPPS(ph)PPLPK ddPTM_A459_Selumetinib_30min_R2 2 ESVSTEDLSPPSPPLPK 17 0 Q13127-4;Q13127 Q13127-4 REST RE1-silencing transcription factor 1 ESVSTEDLS(0.014)PPS(0.986)PPLPK;ESVSTEDLS(0.004)PPS(0.996)PPLPK 183.36 6.584399999999999e-08 24805000.0 109367.0 99006.0 103532.0 119279.0 113333.0 81265.0 96375.0 104194.0 84837.0 98450.0 True False 103288.81997078937 106599.44184553434 96870.86383711838 103032.99443224832 99095.09533012495 92458.5160997789 100856.62846343963 104497.18728975479 101806.77054383447 95607.49269618075 1.0803423147913538 1.114969536794397 1.0132141436336202 1.0776665251505355 1.0364783400923088 0.9670634956780156 1.0549029748530219 1.092981149728751 1.0648409206520417 1.0 16.544836065245413 -5.2548409651266 24.872812067524727 1.0410905403616737 1.0976559283912135 0.29403898735179324 0.036539878873759465 658.3423368767382 2481616.540158118 0.009817253638376192 0.024841573846666867 5.561078618658789e-06 5.2548409651266 0.05656538802953981 ESWVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 ESWVSPR 7 0 Q8IYH5-4;Q8IYH5-2;Q8IYH5 Q8IYH5-4 ZZZ3 ZZ-type zinc finger-containing protein 3 1 ES(0.005)WVS(0.995)PR 83.647 0.038904 15883000.0 45927.0 47247.0 50693.0 58728.0 57864.0 54845.0 41037.0 37791.0 42713.0 49425.0 True False 43374.56120034785 50870.692976950464 47431.467570365196 50729.14508854927 50594.60700927663 62399.40091665995 42945.30181327287 37900.96555336315 51256.79350093482 47997.97182842792 0.9036748751675014 1.0598508861747593 0.9881973292519998 1.0569018472256309 1.0540988521375563 1.300042450537513 0.8947315933844836 0.789636814006283 1.0678949869831122 1.0 15.550685825073066 ESYDAPPT(ph)PSGAR ddPTM_A459_Selumetinib_30min_R1 2 ESYDAPPTPSGAR 13 0 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 ESYDAPPT(0.992)PS(0.008)GAR;ESYDAPPT(0.991)PS(0.009)GAR 204.18 4.6741e-29 16870000.0 6785.5 8899.1 8418.7 9030.400000000001 7222.799999999999 7814.2 8818.400000000001 7344.2 4980.6 5670.799999999999 True False 6943.5889477154 7857.189234920654 7275.48678060895 7453.410161602331 6569.499015288913 7735.596242725922 8153.220988265432 7149.4079586763255 8451.71443136864 6398.702418269651 1.085155785318283 1.2279347782273347 1.1370253381116604 1.1648315040126362 1.0266923800881256 1.2089320204420126 1.2741991196506122 1.1173215272932917 1.3208481780989227 1.0 12.643563657817538 ESYDAPPT(ph)PSGAR ddPTM_A459_Selumetinib_30min_R2 1 ESYDAPPTPSGAR 13 0 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 ESYDAPPT(0.958)PS(0.042)GAR 155.14 0.00085527 7428900.0 42572.0 39592.0 42738.0 46915.0 44923.0 44438.0 34385.0 40604.0 32713.0 42527.0 True False 40206.0186692187 42628.579091655 39988.28360961606 40525.096067110855 39279.3711232845 50558.93113199986 35983.97063258491 40722.15091764593 39256.5140775895 41299.13501158428 0.9735317376003404 1.0321906035004806 0.9682595918388962 0.9812577443993364 0.9510942810852275 1.2242128344290562 0.8713008304530232 0.9860291482188063 0.9505408301306594 1.0 15.33382394503034 ESYS(ph)IYVYK ddPTM_A459_Selumetinib_30min_R2 2 ESYSIYVYK 9 0 Q16778;P33778;P23527;P06899;Q8N257;Q6DRA6;Q6DN03 Q16778 HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB;HIST2H2BD;HIST2H2BC Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B;Putative histone H2B type 2-D;Putative histone H2B type 2-C 1 ESYS(1)IYVYK;ES(0.002)YS(0.997)IYVYK 124.1 0.0054157 7236900.0 54503.0 62568.0 61664.0 52923.0 47594.0 43597.0 43549.0 40922.0 42303.0 58405.0 True False 51473.94145279591 67366.76441217081 57696.60537468683 45714.79610273282 41614.816224241535 49602.09101583776 45574.114790706415 41041.076244998214 50764.78204457766 56718.69589558588 0.9075304119748258 1.1877347204207074 1.0172413956925455 0.8059916643162905 0.7337054487439335 0.874528058740117 0.8035113302781915 0.7235899132898123 0.8950273140629176 1.0 15.791536741347608 -5.708732320164201 5.004209486240917 0.8182189035321573 1.058602291189328 0.4638159191629829 0.09930711664384251 0.1440561622858529 7.5695056561656076 0.025786953431436534 0.044679744386230624 1.9555443951399078e-06 5.708732320164201 0.2403833876571707 ESYS(ph)VYVYK ddPTM_A459_Selumetinib_30min_R1 1 ESYSVYVYK 9 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 1 ES(0.002)YS(0.998)VYVYK 166.86 0.00087907 31468000.0 2881.3 5350.0 5273.8 6476.5 4023.7 4592.6 4362.0 3846.1 1300.0 2517.2 True False 2948.42868396616 4723.619512852478 4557.646926909791 5345.500853961895 3659.7570454419333 4546.402613747163 4032.9708281336516 3744.0889341065063 2206.0050517566597 2840.3071396043533 1.0380668494805345 1.6630664504510115 1.6046317186473917 1.882015074857893 1.2885074978024127 1.600672881588596 1.4199065910510766 1.3181986137696529 0.7766783461537718 1.0 11.471831230175559 -8.055100124416661 2.652520815660205 0.8891457684596743 1.521201031445221 0.5358520458782101 0.22244344076719727 0.2143266582596403 2.7955825632396256 0.17721565039825407 0.0593103705633318 8.808457750175701e-09 8.055100124416661 0.6320552629855466 ESYS(ph)VYVYK ddPTM_A459_Selumetinib_30min_R2 3 ESYSVYVYK 9 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 1 ES(0.136)YS(0.864)VYVYK;ES(0.015)YS(0.985)VYVYK;ES(0.266)YS(0.734)VYVYK 149.96 0.0013707 36689700.0 126730.0 130057.0 119143.0 110135.0 98325.0 93811.0 79834.0 104364.0 73353.0 118073.0 True False 119686.85394038534 140031.9537008329 111477.46909308995 95134.42300652794 85972.53446334729 106732.61371853003 83546.4391880699 104667.68196160973 88025.64965406475 114663.9256995039 1.0438056538727347 1.2212380907645721 0.9722104699714835 0.8296804982575225 0.7497783975114611 0.930829928134859 0.7286200841144876 0.9128213718751352 0.7676838998583632 1.0 16.807052052361087 -5.5245969475569865 3.6111079120549237 0.8377025445649606 1.1309432259711294 0.6135934592811358 0.09053826678356768 0.1274334919189602 3.5738965930137216 0.022959027859812655 0.04682807840589791 2.9881545267679514e-06 5.5245969475569865 0.29324068140616877 ESYSIYVYK ddPTM_A459_Selumetinib_30min_R1 1 ESYSIYVYK 9 0 Q16778;P33778;P23527;P06899;Q8N257;Q6DRA6;Q6DN03 Q16778 HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB;HIST2H2BD;HIST2H2BC Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B;Putative histone H2B type 2-D;Putative histone H2B type 2-C 0 156.51 0.011658 14348000.0 1559.7 1620.9 1729.4 1855.2 1681.2 1690.1 1685.9 1591.7 1004.1 1875.9 False True 1596.0379753521063 1431.124274464033 1494.556978914216 1531.2241464170613 1529.1357568399674 1673.0991284880197 1558.7312056741239 1549.482945429741 1703.8843634375867 2116.690037813367 0.7540253635817566 0.6761142391648646 0.7060821151018212 0.7234049950926602 0.7224183652414368 0.7904318056017328 0.7364003126713636 0.7320311041055517 0.80497585050184 1.0 11.047594305235798 -14.453714121613466 0.2057138420226835 2.2196172790548383 0.695760205817766 0.8934613465264455 0.028155666193383975 40.51230091533598 0.412197382772204 20.2764769611124 0.06295497096400353 3.517919346449605e-15 14.453714121613466 -1.5238570732370724 ESYSVYVYK ddPTM_A459_Selumetinib_30min_R1 1 ESYSVYVYK 9 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 0 152.47 0.015291999999999997 43346000.0 1859.3 1774.4 2118.5 2241.3 1813.6 1872.8 2130.4 1816.2 1622.4 2048.7 False True 1902.6180724319872 1566.6524231038197 1830.8193360875257 1849.8990294116861 1649.5602002170854 1853.9613323663475 1969.7022128051203 1768.0284761509668 2753.0943045923123 2311.6706010279013 0.8230489549791281 0.6777143864732269 0.7919897130990196 0.8002433515350824 0.7135792614586163 0.8020006533551839 0.8520687211790805 0.7648271667099975 1.1909544133874994 1.0 11.17472012189512 -8.252142380196553 24.988055436543423 1.0954772084223174 0.7771337469455697 0.7955137409240605 0.06434533038027741 229.45641893462135 616726.7340160151 0.04284057168157069 0.015702851554940445 5.595741192317865e-09 8.252142380196553 -0.31834346147674775 ESYSVYVYK ddPTM_A459_Selumetinib_30min_R2 2 ESYSVYVYK 9 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 0 ; 167.33 0.011731 72235000.0 532610.0 491540.0 572910.0 673220.0 607110.0 453210.0 506610.0 534420.0 451470.0 468520.0 False True 503009.6684067595 529239.5374497899 536049.5943372443 581526.2746307233 530839.4141677367 515635.56366924 530168.3688286704 535975.0737220062 541776.6151257707 454992.6102388469 1.1055337099710394 1.163182710092736 1.1781501111761943 1.2781004823912478 1.1666989797682081 1.1332833810170209 1.1652241308938187 1.1779863269441844 1.190737174481508 1.0 18.795483588411123 -11.113807605992516 7.370709719695305 0.99983130081843 1.1746857983085672 0.6031004614635289 0.042138988421739486 0.00012324494749315005 6.840021400005155e-06 0.043045778461904737 0.010430147718100167 7.694712433031352e-12 11.113807605992516 0.17485449749013726 ESYTEEIVS(ph)EAESHVS(ph)GISR ddPTM_A459_Selumetinib_30min_R1 2 ESYTEEIVSEAESHVSGISR 20 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 2 ESYTEEIVS(1)EAES(0.008)HVS(0.988)GIS(0.004)R;ESYT(0.001)EEIVS(0.998)EAES(0.001)HVS(0.971)GIS(0.028)R 92.147 0.005757 964480.0 591.14 751.84 809.47 709.94 1113.6 644.1 785.96 707.25 185.66 612.87 True False 604.9124118417923 663.8142232790667 699.5484201004338 585.9623062243044 1012.875076622048 637.6209387960084 726.6744044199737 688.49143252823 315.051459930109 691.5378343593356 0.874735092986205 0.9599102034584224 1.0115837273726598 0.8473322457724384 1.4646705159095312 0.9220333394870901 1.050809324255107 0.9955947430787674 0.455580944782267 1.0 9.433664373832228 -8.045072102424156 21.954291080846993 0.7270547217740311 1.0230413761404866 0.244519381382151 0.20277879427108522 146.98806353526592 71594.06438527966 0.13097687181562587 0.04951774547633598 9.01421469416722e-09 8.045072102424156 0.29598665436645555 ESYTEEIVS(ph)EAESHVSGISR ddPTM_A459_Selumetinib_30min_R1 7 ESYTEEIVSEAESHVSGISR 20 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR 266.28 3.9247e-49 98197000.0 12955.66 16823.059999999998 14499.649999999998 15762.86 26528.91 15610.420000000002 22950.23 14340.990000000002 4105.262 9145.65 True False 13257.501670674012 14853.408314371592 12530.677170876323 13010.172406528489 24129.374774559474 15453.393347927313 21219.07567376381 13960.620359099365 6966.329777526657 10319.58326367493 1.2846935125123313 1.4393418740711932 1.2142619377842974 1.26072653072382 2.3382121310552524 1.4974823065116847 2.056195015980465 1.352827919732082 0.6750592150410019 1.0 13.333097091050055 -8.09524095640374 4.923910549233936 0.8574220447727896 1.5857153874120484 0.4169528983453472 0.34786099822690053 0.22982035973397347 8.835190136065224 0.25780483461838616 0.0934847964223517 8.030804313657124e-09 8.09524095640374 0.7282933426392588 ESYTEEIVS(ph)EAESHVSGISR ddPTM_A459_Selumetinib_30min_R2 4 ESYTEEIVSEAESHVSGISR 20 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR;ESYTEEIVS(1)EAESHVSGISR 203.53 3.318e-16 9904370.0 18597.1 16052.900000000001 35864.3 56690.799999999996 63172.8 33256.5 26713.0 28606.4 33660.9 46242.8 True False 17563.54763208982 17284.10581179099 33556.829984097385 48969.41524291525 55236.468092002455 37837.28100255082 27955.207430805312 28689.639887955538 40394.02056412843 44907.65021077646 0.39110368833938913 0.38488110000561404 0.7472408337242453 1.0904470622059868 1.2300012989490017 0.8425575781622846 0.6225043461324752 0.638858629950558 0.8994908523277644 1.0 15.454673614738637 -5.354663686834402 3.652537690015519 0.8892141107680059 0.38258115900592815 0.5708394544719133 0.17558808548300098 0.19152278116965507 4.706398495758545 0.054553947801903355 0.12853888481413422 4.419125273860081e-06 5.354663686834402 -0.5066329517620778 ESYTEEIVSEAESHVS(ph)GISR ddPTM_A459_Selumetinib_30min_R1 1 ESYTEEIVSEAESHVSGISR 20 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 ESYTEEIVSEAES(0.002)HVS(0.958)GIS(0.04)R 160.84 5.493899999999999e-07 2850900.0 698.94 946.32 865.19 1091.9 840.21 841.25 867.09 679.16 371.43 784.21 True False 715.2239420995069 835.5244144677679 747.7019501484858 901.2201625015044 764.213153851124 832.7877887938864 801.6847032018362 661.1464705774096 630.2895818261362 884.8709923522681 0.808280470578219 0.9442330257054519 0.8449841351007072 1.018476331906615 0.863643582461216 0.9411403424809667 0.9059904891567342 0.747167074400159 0.7122954501544076 1.0 9.78932332603214 -7.7433969221584675 24.44344441019188 0.797298468555158 0.9074124420825946 0.13973817942442512 0.09016500200558952 247.2751310349944 335002.76370302134 0.03995911729900767 0.02300520914989872 1.8055232190940245e-08 7.7433969221584675 0.11011397352743668 ESYTEEIVSEAESHVS(ph)GISR ddPTM_A459_Selumetinib_30min_R2 2 ESYTEEIVSEAESHVSGISR 20 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 ESYTEEIVSEAES(0.007)HVS(0.949)GIS(0.043)R;ESYTEEIVSEAES(0.032)HVS(0.962)GIS(0.006)R 196.95 1.028e-15 4484700.0 19157.9 17578.1 21559.0 21648.0 20445.0 17156.2 19157.5 19980.9 19131.0 18837.5 True False 18093.18061315008 18926.283747500023 20171.91741166438 18699.50505511704 17876.51631938097 19519.31082152249 20048.36170986608 20039.04111098393 22957.734564801904 18293.61242929714 0.989043617441787 1.0345842747378677 1.1026754551418803 1.0221876694605088 0.9771999045279766 1.06700144091073 1.0959214199683556 1.095411919785263 1.254959054890394 1.0 14.159052370941682 -7.344589013677824 1.9604507686373305 1.1294873801154863 1.0301600175526855 0.2652380079320088 0.06630738928866978 0.43855137111748144 3.2868354051358657 0.03493862911791469 0.020694048099097313 4.522837520449682e-08 7.344589013677824 -0.09932736256280084 ET(ph)DVSPFPPR ddPTM_A459_Selumetinib_30min_R1 1 ETDVSPFPPR 10 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3 Q9H8V3-2 ECT2 Protein ECT2 1 ET(0.921)DVS(0.079)PFPPR 121.61 0.011047 6283900.0 4005.9 4525.2 4681.6 4800.1 4860.2 3717.9 4137.6 3926.8 2210.7 3335.7 True False 4099.229675875488 3995.3874802915957 4045.8644341880417 3961.852644036515 4420.595768138005 3680.501301583106 3825.497500799128 3822.6485079559634 3751.3964368603465 3763.8695874695027 1.0890998161898198 1.0615106042974634 1.0749215242890835 1.0526009342157145 1.17448165123862 0.9778503787262071 1.0163735517125232 1.0156166198430852 0.9966860832132226 1.0 11.878000926338935 -6.796356101643107 24.9999983134525 1.0032231003716223 1.0859377502972316 0.6488417073506776 0.03271524551435905 121.45759787778188 86961.57910682181 0.011335441484929428 0.00999735191969481 1.598247001639588e-07 6.796356101643107 0.08271464992560928 ET(ph)DVSPFPPR ddPTM_A459_Selumetinib_30min_R2 1 ETDVSPFPPR 10 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3 Q9H8V3-2 ECT2 Protein ECT2 1 ET(0.816)DVS(0.184)PFPPR 110.54 0.021975 7039800.0 26482.0 23147.0 25334.0 24153.0 27560.0 23059.0 24629.0 22824.0 19930.0 34510.0 True False 25010.236455845403 24922.300470664228 23704.038021573633 20863.319733751017 24097.66641047392 26235.167941239164 25774.297301437648 22890.414061283394 23916.556890727203 33513.60663225183 0.7462711110232103 0.7436472219817799 0.7072959434560542 0.6225328107083884 0.7190412740383342 0.7828213844340985 0.7690696374240349 0.6830185217742216 0.7136372146742063 1.0 15.03245933289201 -11.302293622349723 2.6074276498346194 1.0743958761876369 0.720277414816872 0.7897875132711719 0.043209514262412936 17571352.81507785 12872161.907175085 8334926.956146555 0.01220004825587873 4.985473104185934e-12 11.302293622349723 -0.35411846137076486 ET(ph)FVFKVT(ph)LFQLSHVT(ph)LMLSVYNK ddPTM_A459_Selumetinib_30min_R2 1 ETFVFKVTLFQLSHVTLMLSVYNK 24 1 Q58G82 Q58G82 SYT14LP1 Putative synaptotagmin-14-like protein 3 ET(0.998)FVFKVT(0.997)LFQLS(0.174)HVT(0.815)LMLS(0.012)VY(0.004)NK 45.88 0.046672000000000005 0.0 28852.0 24214.0 20747.0 20861.0 18199.0 18724.0 20642.0 19461.0 12855.0 20328.0 True False 27248.52134370709 26071.135939718486 19412.16060762565 18019.695812767764 15912.678918875734 21303.061040451088 21601.893901347037 19517.628288058015 15426.359198710385 19741.07782151305 1.380295523378806 1.3206541291938574 0.9833384368948206 0.9128020250814578 0.8060694083042783 1.0791235024278083 1.094261118701743 0.9886809861409124 0.781434496038476 1.0 14.268913139622487 -5.247029598152806 3.8924047485570497 0.9553241643340294 1.366654392419019 0.7315013808504153 0.09610054101656591 0.11386866680837564 3.97525643172299 0.027056031120311942 0.07351532495470271 5.662006998629141e-06 5.247029598152806 0.41133022808498965 ET(ph)PHSPGVEDAPIAK ddPTM_A459_Selumetinib_30min_R2 1 ETPHSPGVEDAPIAK 15 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 ET(0.936)PHS(0.064)PGVEDAPIAK 209.56 3.2147000000000007e-06 9097200.0 47048.0 42373.0 45843.0 51365.0 57186.0 43455.0 37349.0 40958.0 33283.0 51441.0 True False 44433.260508066385 45622.87284933058 42893.51129008446 44368.99839043272 50001.78343067352 49440.53180478541 39085.80250563947 41077.1809990381 39940.53000472018 49955.76467023085 0.8894521143131379 0.9132654289349257 0.8586298613029768 0.8881657338912211 1.0009211901918917 0.9896862180201503 0.7824082518534863 0.8222710886360711 0.799517938888065 1.0 15.608363547682925 -10.4746237672735 4.978669433067283 1.0000005378102717 0.8849500369215426 0.2055432323836882 0.06905520264295816 106862209.30869329 18.303310040686878 851.4031849035931 0.018435349313521567 3.352557480834202e-11 10.4746237672735 -0.11505050088872903 ET(ph)SHGSPTVTK ddPTM_A459_Selumetinib_30min_R2 1 ETSHGSPTVTK 11 0 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 ET(0.986)S(0.012)HGS(0.002)PTVTK 184.44 5.8777e-05 4119500.0 17839.0 15939.0 13831.0 16287.0 18442.0 15155.0 21783.0 25826.0 14285.0 25228.0 True False 16847.579795175054 17161.4700480372 12941.12851805419 14068.682503357872 16125.151086428163 17242.463686607374 22795.95266219564 25901.149384275544 17142.39915624877 24499.60208978412 0.6876674867384962 0.7004795418776706 0.5282179061777661 0.5742412652989272 0.6581801217560204 0.7037854583686142 0.9304621592895638 1.0572069411313356 0.699701125488762 1.0 14.580470697440276 -7.143535291157217 3.030548618027394 0.9282908098016972 0.6272489380929155 0.6638404027822868 0.09852994427436945 0.1611796591295474 2.8265290006038066 0.04123021392451053 0.030617429266822822 7.185627649563246e-08 7.143535291157217 -0.3010418717087817 ET(ph)VNSPAIYK ddPTM_A459_Selumetinib_30min_R2 1 ETVNSPAIYK 10 0 Q9Y3A2 Q9Y3A2 UTP11L Probable U3 small nucleolar RNA-associated protein 11 1 ET(0.766)VNS(0.233)PAIYK 165.35 0.00083992 9027900.0 64135.0 71179.0 68409.0 57494.0 65783.0 52254.0 48584.0 43586.0 45454.0 71789.0 True False 60570.63345274693 76638.20042344171 64007.63941808751 49663.21801731798 57518.75143251836 59451.51418541616 50843.25226736966 43712.82804394929 54546.07009087373 69716.26503977773 0.8688163862218864 1.099287237773202 0.9181163015770699 0.7123620003019645 0.8250406329096963 0.8527639016733778 0.7292882405326824 0.6270104690635425 0.7824009226505693 1.0 16.0892076605316 -5.590484223720895 5.309465320649822 0.7767482002114358 0.9901483560631499 0.3588944130280415 0.1066323719895235 0.17907750234544675 9.484017752382005 0.02846905326085343 0.05070151153291611 2.5675314751383907e-06 5.590484223720895 0.21340015585171412 ET(ph)YYLSDSPLLGPPVGEPR ddPTM_A459_Selumetinib_30min_R1 1 ETYYLSDSPLLGPPVGEPR 19 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 ET(0.654)Y(0.263)Y(0.04)LS(0.035)DS(0.007)PLLGPPVGEPR 185.71 5.455e-15 7100400.0 1900.9 1841.2 2223.4 2251.7 1987.5 1414.6 1906.4 1787.4 1156.4 1553.2 True False 1945.1872714924782 1625.6314480493425 1921.4744922619798 1858.4828646438648 1807.7309759216248 1400.3704083540338 1762.5987131485547 1739.9923457065522 1962.3263398856934 1752.5683494491818 1.109906653343269 0.927570926726062 1.096376351236677 1.0604338856330318 1.0314753067917608 0.7990389697464062 1.0057232368155715 0.9928242434900858 1.1196860541858107 1.0 10.775254994511984 -4.7297467540672145 23.77996962885258 1.0026643540186977 1.109907939111921 0.12078052140388662 0.08594126820702844 5312.1271622120075 3985442.004271002 0.022053679849107454 2.829376627361027 1.863173274134307e-05 4.7297467540672145 0.1072435850932234 ETAPEEPGS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 ETAPEEPGSPAK 12 0 P35612 P35612 ADD2 Beta-adducin 1 ETAPEEPGS(1)PAK;ETAPEEPGS(1)PAK 236.42 4.0132e-13 69581000.0 14068.2 17768.4 9204.1 9742.400000000001 9993.0 11027.0 13189.3 14503.7 7909.400000000001 15839.199999999999 True False 14395.961688048015 15688.067467694947 7954.233774502336 8041.072727497625 9089.134914407441 10916.07839171492 12194.420482233643 14119.014761342802 13421.6741202801 17872.315606873206 0.8054894510989791 0.8777859463080288 0.44505893637214833 0.4499177892989562 0.5085594454762207 0.6107814248488815 0.6823078078110931 0.7899935896338476 0.7509756662487814 1.0 14.12543894723189 -8.419109775067417 0.904683755956839 0.9877558383700552 0.6114461932430282 0.41119837382449353 0.13624569397366296 0.6354355928829957 1.1501577393202471 0.1459726395236926 0.05148126035160139 3.8096951491683215e-09 8.419109775067417 -0.376309645127027 ETAPEEPGS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 3 ETAPEEPGSPAK 12 0 P35612 P35612 ADD2 Beta-adducin 1 ETAPEEPGS(1)PAK;ETAPEEPGS(1)PAK;ETAPEEPGS(1)PAK 211.82 4.497e-06 117722000.0 701620.0 507015.0 624794.0 646915.0 584483.0 600205.0 891013.0 829628.0 754935.0 490263.0 True False 662626.769207395 545901.4201898229 584595.4342642723 558804.0610093805 511055.02019568323 682877.7906314868 932446.8700087654 832042.0801276916 905943.0946463178 476107.83333374874 1.3917577548926772 1.1465919734346175 1.227863507665656 1.1736922224038733 1.0734018312978202 1.434292281750369 1.958478320929296 1.7475916627997068 1.9028107315580693 1.0 18.860928839980474 -7.011422389294664 5.687986579516483 1.7144459447962366 1.202496672084474 0.3951840647099467 0.2577212891944179 0.14282089480049315 16.365978900609175 0.09011054927434067 0.07391040303332032 9.740418361691955e-08 7.011422389294664 -0.5119492727117625 ETAPTSAYS(ph)SPAR ddPTM_A459_Selumetinib_30min_R1 2 ETAPTSAYSSPAR 13 0 A0A6I8PIW1;O43301;A0A6I8PIU5;A0A6I8PRZ9;A0A6I8PIX2 A0A6I8PIW1 HSPA12A Heat shock 70 kDa protein 12A 1 ETAPT(0.001)S(0.001)AYS(0.499)S(0.499)PAR;ETAPT(0.007)S(0.007)AY(0.004)S(0.667)S(0.315)PAR 117.27 0.0036493 55873000.0 6466.200000000001 7094.9 7069.900000000001 7710.6 7786.200000000001 6365.1 7514.7 6974.799999999999 3190.3999999999996 5608.8 True False 6616.849878965051 6264.225809670478 6109.84641218088 6364.08845588799 7081.939584765259 6301.072873048393 6947.860128880319 6789.8056466566295 5413.8757824034265 6328.744114338509 1.045523370738565 0.9898055121991965 0.9654121420928221 1.0055847322803595 1.119011838181338 0.9956276884022814 1.0978260462670835 1.0728519788426163 0.8554423570606463 1.0 12.627703522107488 -4.295357588116982 15.379484515591983 1.0175387689425188 89.37040835648239 0.013731846432374684 0.07105951752026429 316963.6817015117 1089109.657804466 0.017593415752390325 941027786.8016341 5.0657343556199304e-05 4.295357588116982 88.35286958753987 ETAPTSAYS(ph)SPAR ddPTM_A459_Selumetinib_30min_R2 2 ETAPTSAYSSPAR 13 0 A0A6I8PIW1;O43301;A0A6I8PIU5;A0A6I8PRZ9;A0A6I8PIX2 A0A6I8PIW1 HSPA12A Heat shock 70 kDa protein 12A 1 ETAPT(0.002)S(0.002)AYS(0.498)S(0.498)PAR;ETAPT(0.009)S(0.009)AYS(0.71)S(0.271)PAR 98.902 0.012179 65726000.0 140648.0 109146.0 119043.0 138797.0 154082.0 104401.0 111904.0 116502.0 100215.0 125800.0 True False 132831.34721855388 117517.14724029545 111383.90298421826 119892.6091618198 134724.84164944274 118781.29009208144 117107.75773356944 116841.00153205558 120260.80024105503 122167.82713234691 1.0872858291459582 0.9619320405280412 0.9117286080856116 0.9813762917460885 1.1027849542047805 0.9722796327007047 0.958580998634806 0.9563974761168449 0.9843901055125917 1.0 16.89850487622315 -10.310993174969331 5.396820206297474 1.0000000034298446 0.9880984650599299 0.0004317006339343843 0.05629704196466985 2.4036591810916807e-09 6.226921847218343e-10 0.05638078740804167 0.013674345642539948 4.886600386795132e-11 10.310993174969331 -0.0119015383699147 ETAVPGPLGIEDISPNLS(ph)PDDKSFSR ddPTM_A459_Selumetinib_30min_R1 2 ETAVPGPLGIEDISPNLSPDDKSFSR 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 ETAVPGPLGIEDIS(0.047)PNLS(0.946)PDDKS(0.003)FS(0.004)R;ETAVPGPLGIEDIS(0.002)PNLS(0.994)PDDKS(0.002)FS(0.002)R 135.78 2.3658e-09 19622800.0 6068.299999999999 5348.1 9794.7 9514.1 6835.6 6272.8 6153.1 5411.6 4523.8 5072.8 True False 6209.679583143667 4721.941965735762 8464.63353843592 7852.641036775859 6217.321186923203 6209.701327246698 5688.966713110769 5268.066788645845 7676.558194720607 5723.943293256378 1.0848604301268245 0.8249456229412482 1.4788115648190414 1.3718935765886064 1.086195454495172 1.0848642289245969 0.9938894258112556 0.9203562157669136 1.3411310702125034 1.0 12.482793664109083 -6.497415087688727 24.484322063996093 1.0614459618096297 1.1902112429848333 0.08478125309534834 0.19179008482911267 1592.2740636047272 1531035.8768284277 0.0630166933326069 0.07114894184166273 3.1811556001449774e-07 6.497415087688727 0.12876528117520358 ETAVPGPLGIEDISPNLS(ph)PDDKSFSR ddPTM_A459_Selumetinib_30min_R2 1 ETAVPGPLGIEDISPNLSPDDKSFSR 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 ETAVPGPLGIEDIS(0.104)PNLS(0.868)PDDKS(0.021)FS(0.006)R 80.36 7.8241e-05 5106300.0 31865.0 42159.0 38228.0 39901.0 39196.0 26046.0 22678.0 27315.0 20498.0 36643.0 True False 30094.070865701742 45392.459737449055 35768.45209949932 34466.41496693577 34271.84806331407 29633.60007795286 23732.571935604486 27394.48212775833 24598.17276197321 35585.02138005228 0.8456948934860392 1.275605802021366 1.0051547171347173 0.9685652454393757 0.963097582471193 0.8327548763133361 0.6669258866571354 0.7698318299483927 0.6912507512433892 1.0 15.118982482311775 -6.6218546597059875 1.5912199533685154 0.7604995479505037 1.0491379048604557 0.41432725702952355 0.13101902379030564 0.320870061634909 1.6748342941928143 0.05190370715395935 0.05274981250069593 2.3886105177311197e-07 6.6218546597059875 0.288638356909952 ETCSTLAES(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 ETCSTLAESPR 11 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 ETCSTLAES(1)PR;ETCSTLAES(1)PR;ETCSTLAES(1)PR 185.3 2.0306e-05 172122100.0 7261.699999999999 7947.2 8372.5 8391.699999999999 8320.1 6662.0 7637.8 7105.6 4418.4 6179.299999999999 True False 7430.883481191499 7016.738129446953 7235.560486850513 6926.2471267184455 7567.548424032965 6594.986328612025 7061.674596771943 6917.136405758355 7497.7020928320235 6972.473346479094 1.0657456991131977 1.0063485051527965 1.0377322547248273 0.9933701833677153 1.0853463395244627 0.9458603856753802 1.0127933440344943 0.9920635134806671 1.0753288998398474 1.0 12.767454798967531 -6.752033208593783 24.999995962894552 1.0051871998399369 1.03350441881951 0.14716655788848854 0.038457363631509145 446.85761879257234 1187670.086056831 0.012333651233914045 0.01216257067035232 1.7699736110256118e-07 6.752033208593783 0.028317218979573067 ETCSTLAES(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 ETCSTLAESPR 11 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 ETCSTLAES(1)PR;ETCSTLAES(1)PR;ETCSTLAES(1)PR 179.6 5.2501e-05 239437600.0 127595.0 114399.0 130694.0 137376.0 159493.0 108633.0 126858.0 128443.0 104684.0 131200.0 True False 120503.78070325492 123173.03544923833 122285.29032886813 118665.15181318202 139456.0634544892 123596.20967781042 132757.14836435817 128816.74786511682 125623.72511534822 127411.91510146158 0.9457810959618217 0.9667309007258253 0.9597633803046522 0.9313505076717961 1.0945292152891395 0.9700522088486574 1.0419523814443887 1.011025913569673 0.9859652844501288 1.0 16.95914067396194 -6.213161562840206 24.99999090327666 1.0166804347959957 0.9526694105474174 0.4923809219413262 0.032980196675689855 335.8617368015542 173921.05264765464 0.009195078279110851 0.011870739315189949 6.12122632283339e-07 6.213161562840206 -0.0640110242485783 ETDKS(ph)PTSTEPR ddPTM_A459_Selumetinib_30min_R1 2 ETDKSPTSTEPR 12 1 Q6IQ19;Q6IQ19-2 Q6IQ19 CCSAP Centriole, cilia and spindle-associated protein 1 ET(0.015)DKS(0.539)PT(0.391)S(0.049)T(0.006)EPR;ET(0.002)DKS(0.825)PT(0.144)S(0.025)T(0.004)EPR 129.17 0.011143 10927100.0 2361.5 2998.8999999999996 2527.8 2699.3 2498.3 2288.67 2313.0 2210.38 1279.18 2302.3 True False 2416.518355320894 2647.7873938492135 2184.5386442114923 2227.917927136468 2272.329206110691 2265.648057746095 2138.5285477930174 2151.753542073877 2170.6750323892975 2597.8226313010905 0.9302091398405471 1.0192333233016369 0.8409113916747235 0.8576097152639863 0.8747052930910145 0.87213346686851 0.8232003686571778 0.8282911682065819 0.8355747641255011 1.0 11.343087217496514 -5.2695217674835995 24.945719290914475 0.8590435157873105 0.9747212330419011 0.400384841151447 0.052306859201138506 441.47523736917583 1362585.3225249092 0.012726183665493208 0.027237068946075266 5.376234859603987e-06 5.2695217674835995 0.11567771725459053 ETDKS(ph)PTSTEPR ddPTM_A459_Selumetinib_30min_R2 1 ETDKSPTSTEPR 12 1 Q6IQ19;Q6IQ19-2 Q6IQ19 CCSAP Centriole, cilia and spindle-associated protein 1 ETDKS(0.96)PT(0.04)STEPR 125.47 0.013636 5605400.0 9868.7 7965.4 9482.7 9024.6 9280.1 7809.7 8418.9 7043.1 7883.6 8139.1 True False 9320.237161536194 8576.320567202176 8872.593405983116 7795.433911696663 8114.250872853383 8885.415285601952 8810.39553173387 7063.594254952024 9460.540286188501 7904.103035078558 1.1791644314570302 1.0850466560393133 1.1225300792014452 0.9862515553125233 1.0265871834972526 1.1241522594237843 1.114661017528892 0.8936617126071941 1.1969151014609052 1.0 12.948386038167168 -4.383938195653895 1.077000733991278 1.0523397859654608 1.349628090789624 0.17124373371522905 0.081804360101527 6.484209391995041 3.4741293885105073 0.024628120072240522 2.7030555592709047 4.131062868662576e-05 4.383938195653895 0.29728830482416324 ETDKSPT(ph)STEPR ddPTM_A459_Selumetinib_30min_R1 1 ETDKSPTSTEPR 12 1 Q6IQ19;Q6IQ19-2 Q6IQ19 CCSAP Centriole, cilia and spindle-associated protein 1 ET(0.001)DKS(0.006)PT(0.982)S(0.01)T(0.001)EPR 147.7 0.0064536 5791300.0 1076.9 1138.6 1128.6 1455.3 1083.6 846.98 1362.4 1036.2 509.74 1072.7 True False 1101.98967471737 1005.2921826792202 975.3423189560447 1201.1591743643546 985.5885713251183 838.4601501963099 1259.6330711254682 1008.7166099480419 864.9915500634155 1210.3914939828342 0.9104406964156991 0.830551261865921 0.8058073142489194 0.9923724516700788 0.8142725524962223 0.6927181448023304 1.0406823555745612 0.8333804516659529 0.7146378294655158 1.0 10.241258038836396 -10.547056719796606 4.012962491972474 1.0000177228855993 0.8504227563188018 0.1615749670505432 0.10355750419964058 144549131.48247612 384170895.22574884 39889.50506159174 0.025527834308874453 2.837548414293839e-11 10.547056719796606 -0.1495949665667975 ETDPS(ph)PEER ddPTM_A459_Selumetinib_30min_R1 2 ETDPSPEER 9 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H0Y482 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 ETDPS(1)PEER;ET(0.001)DPS(0.999)PEER 161.67 0.00092821 9293100.0 7334.5 7859.400000000001 7891.5 7844.099999999999 8105.0 7207.8 7549.299999999999 7299.6 4011.9 5929.5 True False 7505.379579547359 6939.217794264065 6819.877644906639 6474.275186993357 7371.904181053974 7135.296076158775 6979.850223023704 7105.990895557542 6807.901282417342 6690.609083221045 1.1217782247014887 1.0371578593145563 1.0193208959121194 0.9676660385419591 1.1018285613998142 1.0664643513627081 1.0432309130910111 1.062084304608112 1.017530870170019 1.0 12.70792183803164 -9.554899635098153 0.005167015778401278 5.109503006059271e-09 2.055587439886961 0.12662186495435357 0.041103470780290606 37611.067370861594 57.68011125074806 11693.131998077828 11252.9338402466 2.786765112089092e-10 9.554899635098153 2.055587434777458 ETDPS(ph)PEER ddPTM_A459_Selumetinib_30min_R2 1 ETDPSPEER 9 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H0Y482 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 ET(0.005)DPS(0.995)PEER 89.561 0.029706 17840000.0 45038.0 36365.0 39681.0 41940.0 41885.0 34301.0 35455.0 38052.0 30132.0 35765.0 True False 42534.96826139888 39154.07856809544 37127.96766140614 36227.69964946458 36623.03184334908 39025.651396523856 37103.727752749684 38162.725020152306 36159.241958424056 34732.37152137024 1.2246491212161494 1.127307950855144 1.0689730080355133 1.0430528657444047 1.054435105901581 1.1236103291280308 1.0682751026638186 1.0987653116825447 1.0410818603669458 1.0 15.08399330064411 -4.834766643375019 2.0742077590030292 1.0670605661099855 1.2583715362355772 0.7121877443952183 0.03189978065634235 0.335952577735847 1.7899484372740546 0.008419400362837613 0.11798152144161617 1.4629630477084638e-05 4.834766643375019 0.19131097012559173 ETDPVKS(ph)PPLPEHQK ddPTM_A459_Selumetinib_30min_R1 1 ETDPVKSPPLPEHQK 15 1 Q96JM3;A0A2R8Y4S6;S4R3K0;A0A2R8Y735 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 ET(0.007)DPVKS(0.993)PPLPEHQK 62.081 0.04255 8733900.0 7367.8 8354.7 6497.8 6465.8 5969.0 6698.8 6713.0 6134.6 3963.1 5238.9 True False 7539.455404756842 7376.5278400053485 5615.434449860528 5336.669408098014 5429.105003912542 6631.416154023756 6206.633005332693 5971.890480010862 6725.0912466283235 5911.363846207391 1.2754172473403071 1.2478554918824656 0.9499388966665069 0.9027814133826174 0.9184183456066138 1.1218081523231453 1.0499494138420764 1.0102390303453075 1.137654764888648 1.0 12.529275306293735 -5.249932758791109 22.754803911709068 1.0098416607963785 1.261636574280291 0.6482915705355151 0.07373372540335152 143.27666782197414 283329.6015825847 0.020490521671914754 0.052966487965703815 5.624283984539316e-06 5.249932758791109 0.2517949134839126 ETDPVKS(ph)PPLPEHQK ddPTM_A459_Selumetinib_30min_R2 3 ETDPVKSPPLPEHQK 15 1 Q96JM3;A0A2R8Y4S6;S4R3K0;A0A2R8Y735 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 ET(0.014)DPVKS(0.986)PPLPEHQK;ET(0.02)DPVKS(0.98)PPLPEHQK;ET(0.001)DPVKS(0.999)PPLPEHQK 81.185 0.011887 168419200.0 231962.0 208994.0 219395.0 236321.0 216374.0 171416.0 208167.0 218037.0 150807.0 209177.0 True False 219070.48065745845 225023.1677783734 205279.36455921497 204133.67212353615 189191.1637118972 195026.99804048095 217847.17797508536 218671.45157203145 180972.61389964333 203137.51650288457 1.0784343750424241 1.1077381059503997 1.0105438330309606 1.0049038485741133 0.9313452628983514 0.9600737539671139 1.0724123329133637 1.0764700452017504 0.8908872029902635 1.0 17.63209718317143 -5.346198252468699 4.278503006000035 0.9946397269725312 1.093203327993639 0.3535236287469884 0.054196692227637074 0.2494425995805303 8.218164411803238 0.015011552131493343 0.03386611804306341 4.506109567556273e-06 5.346198252468699 0.09856360102110784 ETDSPS(ph)TPGKDQR ddPTM_A459_Selumetinib_30min_R2 1 ETDSPSTPGKDQR 13 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 ETDS(0.008)PS(0.953)T(0.039)PGKDQR 247.11 8.903899999999995e-78 0.0 41046.0 31570.0 34416.0 38613.0 34499.0 28809.0 35955.0 37256.0 26042.0 39457.0 True False 38764.82764015671 33991.317486450505 32201.71202930758 33353.84278885971 30164.927195026838 32777.1782479361 37626.97874348091 37364.408791937196 31251.127674275842 38317.77388840222 1.0116670074064456 0.8870900899788122 0.8403857730120953 0.870453562516455 0.787230680020192 0.8554040311265809 0.9819719395251614 0.9751195072228979 0.8155778507721383 1.0 15.225726128163954 -7.247673910258707 24.431002913605887 0.9410939514878758 0.870084248659849 0.17723308597556287 0.07095787488055876 1034.2229866432372 1835545.5355534134 0.027814240407892245 0.021419658219714203 5.6536131667651826e-08 7.247673910258707 -0.07100970282802677 ETDSPST(ph)PGKDQR ddPTM_A459_Selumetinib_30min_R1 1 ETDSPSTPGKDQR 13 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 ETDSPS(0.062)T(0.937)PGKDQR 98.676 0.017113 26673000.0 14728.0 16578.0 14441.0 15059.0 12885.0 14414.0 14557.0 14025.0 8186.7 13853.0 True False 15071.133744300696 14637.040053096896 12479.99151873493 12429.228342439916 11719.554025031519 14269.008246864874 13458.95377009206 13653.011440379536 13892.231967089436 15631.167489646874 0.9641719823092478 0.9364009478365307 0.7984043115781921 0.7951567501705982 0.7497555146020816 0.9128562058026561 0.8610331748416389 0.8734479653821413 0.8887520382780619 1.0 13.932137916595986 -8.99718501774716 0.9219075267622289 1.000434164462882 0.8546539751976387 0.3024793548993846 0.063057005290522 2.2289780986890237 2.9588225388679166 0.06855213636304477 0.02209839509645642 1.00650278808407e-09 8.99718501774716 -0.14578018926524328 ETDSPST(ph)PGKDQR ddPTM_A459_Selumetinib_30min_R2 1 ETDSPSTPGKDQR 13 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 ETDSPS(0.043)T(0.957)PGKDQR 236.05 2.2780999999999992e-63 0.0 27891.0 25548.0 29085.0 27031.0 30156.0 22842.0 25868.0 31151.0 22614.0 25639.0 True False 26340.92987651929 27507.44945023243 27213.702765353617 23349.3311689241 26367.53368193946 25988.278160969014 27070.913256469586 31241.644252674316 27137.43188795307 24898.735451877863 1.057922396397551 1.104772951357167 1.0929752965948782 0.9377717681306219 1.0589908765808755 1.0437589576063782 1.087240486923118 1.2547482306101643 1.0899120535820772 1.0 14.603784852620661 -7.528396473611919 24.9984854057689 1.1375969550491194 1.0505869533317558 0.12137816631005405 0.07249993754998435 225.7221612011945 1022630.4148129195 0.033279201940374314 0.019288010972254462 2.9621259878512656e-08 7.528396473611919 -0.08701000171736362 ETDVS(ph)PFPPR ddPTM_A459_Selumetinib_30min_R1 3 ETDVSPFPPR 10 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3 Q9H8V3-2 ECT2 Protein ECT2 1 ET(0.161)DVS(0.839)PFPPR;ET(0.039)DVS(0.961)PFPPR;ET(0.329)DVS(0.671)PFPPR 109.16 0.010241 20732100.0 6239.200000000001 6885.900000000001 7350.5 7626.700000000001 8070.8 6228.6 6714.900000000001 6121.1 3390.8999999999996 5118.5 True False 6384.561220630157 6079.695626831942 6352.342473406353 6294.840015889936 7340.797565015471 6165.945939116314 6208.389686802995 5958.74854386504 5754.109638462814 5775.509333412073 1.10545422958537 1.0526683060938213 1.0998757177409835 1.0899194603449893 1.2710216781311394 1.0676021079985991 1.074951026550447 1.0317269352146838 0.9962947519060424 1.0 12.49573246588962 -7.660983186041636 1.7069189708627837 1.0007160595120201 1.1166041369872832 0.42452834401073913 0.05589111581975385 0.4012727457958757 2.266360857066225 0.042025395997460996 0.018201092570782562 2.1828144191113015e-08 7.660983186041636 0.11588807747526308 ETDVS(ph)PFPPR ddPTM_A459_Selumetinib_30min_R2 1 ETDVSPFPPR 10 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3 Q9H8V3-2 ECT2 Protein ECT2 1 ET(0.002)DVS(0.998)PFPPR 108.31 0.010756 6875600.0 61109.0 60346.0 57370.0 74504.0 62577.0 58267.0 55635.0 50879.0 51461.0 64278.0 True False 57712.8064187092 64974.34415702699 53678.876659733105 64356.42667343124 54715.51781452203 66292.75035483685 58222.137738661084 51027.049466528144 61754.637940477296 62422.127125699364 0.9245568691129828 1.0408864155844646 0.8599334744174932 1.0309874020126994 0.8765404245892078 1.062007230566546 0.9327163366512524 0.8174513079917164 0.9893068497349033 1.0 15.929769899597511 -7.50970341238099 24.983634142097458 0.9170442164188031 0.9661586131813992 0.020106564697424556 0.07876685617807837 1674.503298618859 3175284.5981756533 0.031957683663993895 0.020429312672587224 3.092406572387369e-08 7.50970341238099 0.0491143967625961 ETDYPAGEDLSES(ph)GQVDK ddPTM_A459_Selumetinib_30min_R1 2 ETDYPAGEDLSESGQVDK 18 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;H0YBS5;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 ETDYPAGEDLS(0.071)ES(0.929)GQVDK;ETDYPAGEDLS(0.008)ES(0.992)GQVDK 216.16 3.7454e-14 46775000.0 4604.4800000000005 7746.3 5087.4400000000005 5099.09 4916.88 5840.92 6573.92 6345.23 3809.6299999999997 5933.14 True False 4711.75542524156 6839.359594842829 4396.593591307587 4208.629653273922 4472.1490721456685 5782.165647931034 6078.043921706647 6176.933888188195 6464.663865633636 6694.716312677645 0.7038021038052064 1.0216055879606543 0.6567258993457048 0.6286494388573459 0.6680117369091283 0.8636909135315364 0.9078867031597413 0.922658048480869 0.965636714641909 1.0 12.708807207580685 -7.006976909012065 3.3385926105238766 0.9406561700814072 0.7416957571211512 0.47313974346687515 0.10578011146564702 0.2571983934783633 5.994861114625619 0.04466011640932552 0.03619864120977198 9.840634260036787e-08 7.006976909012065 -0.19896041296025602 ETDYPAGEDLSES(ph)GQVDK ddPTM_A459_Selumetinib_30min_R2 2 ETDYPAGEDLSESGQVDK 18 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;H0YBS5;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 ETDYPAGEDLSES(1)GQVDK;ETDYPAGEDLS(0.026)ES(0.974)GQVDK 206.7 1.9277e-11 37571000.0 183644.0 149642.0 169652.0 177133.0 181240.0 137198.0 165203.0 155239.0 118761.0 161778.0 True False 173437.80166517917 161119.06022513224 158736.77502313137 153007.1798285317 158471.01089384232 156095.77914055798 172885.2668435343 155690.71978879996 142516.51845959094 157107.0487902766 1.1039466593042724 1.0255368009630892 1.0103733489070263 0.9739039782535928 1.0086817371599062 0.9935631809170538 1.1004297272130683 0.9909849429902582 0.9071300082139365 1.0 17.2613883847102 -4.674271800819016 1.953398716905164 1.0007019324403845 1.1564689180040033 0.3395560029813034 0.04439516312995865 1.379368926105938 4.480603561640072 0.012364193152791357 0.4288030584651129 2.117035785327811e-05 4.674271800819016 0.1557669855636188 ETEAAPT(ph)SPPIVPLK ddPTM_A459_Selumetinib_30min_R1 2 ETEAAPTSPPIVPLK 15 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 ETEAAPT(0.5)S(0.5)PPIVPLK;ETEAAPT(0.5)S(0.5)PPIVPLK 214.48 7.324200000000002e-07 82757000.0 13303.599999999999 14624.8 17164.5 17267.699999999997 16876.4 13686.4 14400.4 13481.2 8467.2 12093.400000000001 True False 13613.547995700617 12912.521617114935 14833.65517784959 14252.220349873814 15349.932599770416 13548.72724225692 13314.166234171453 13123.634782890882 14368.219980179996 13645.705689691433 0.9976433835873282 0.9462699775849353 1.0870566546848206 1.044447291622343 1.1248910792035058 0.9928931160000194 0.9757037515640954 0.96174101078591 1.0529481074060085 1.0 13.736159385278565 -9.646904805004196 11.752443841820385 1.0 1.0201113529047803 0.012635175896425155 0.05404468290552045 0.0 0.0 0.05566490793582518 0.013500723238805294 2.2547333833236903e-10 9.646904805004196 0.020111352904780277 ETEAAPT(ph)SPPIVPLK ddPTM_A459_Selumetinib_30min_R2 2 ETEAAPTSPPIVPLK 15 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 ETEAAPT(0.757)S(0.243)PPIVPLK;ETEAAPT(0.663)S(0.337)PPIVPLK 255.39 1.9025e-28 49929000.0 345280.0 348990.0 378420.0 401450.0 393280.0 267010.0 292900.0 340650.0 276910.0 347330.0 True False 326090.71986535384 375756.41082028416 354072.8691925437 346771.8174601235 343872.65043219103 303788.2038245482 306520.4303703394 341641.23510235694 332299.73751185543 337301.6804282821 0.9667628084488242 1.1140069339209189 1.0497216282556514 1.028076163213349 1.019480988044784 0.9006424262067689 0.9087426720825736 1.012865499716944 0.985170714506742 1.0 18.36367998028028 -6.571036540744659 8.297774531398357 0.9588816225948357 1.0430062682681498 0.385045108411489 0.047251277701789406 0.2687576074301745 41.52522026095285 0.016060885759768547 0.016083297397999442 2.685118515185274e-07 6.571036540744659 0.08412464567331412 ETEAAPTS(ph)PPIVPLK ddPTM_A459_Selumetinib_30min_R1 2 ETEAAPTSPPIVPLK 15 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 ETEAAPT(0.028)S(0.972)PPIVPLK;ETEAAPT(0.018)S(0.982)PPIVPLK 178.67 1.9794e-05 8580700.0 5547.1 6370.9 6961.299999999999 7179.6 6391.1 5601.5 5910.5 5649.9 3204.7 4765.1 True False 5676.33663722233 5624.992066248941 6015.993695683784 5925.817637783492 5813.026133440349 5545.153995755067 5464.666226429149 5500.046298538351 5438.141837972744 5376.747001004565 1.0557194965955792 1.0461701220455408 1.118890975260652 1.1021194853833258 1.0811418376862947 1.0313213537328494 1.0163517504930317 1.0229319507707446 1.01141858394243 1.0 12.392517872886339 -6.843125950111399 3.39625514479764 1.0154434844149558 1.0826032051930146 0.7220108774333258 0.02018913490561214 0.14655674439302346 3.357772613376658 0.008266143170188285 0.007354974494298494 1.4350731862054158e-07 6.843125950111399 0.06715972077805876 ETEAAPTS(ph)PPIVPLK ddPTM_A459_Selumetinib_30min_R2 1 ETEAAPTSPPIVPLK 15 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 ETEAAPT(0.046)S(0.954)PPIVPLK 143.64 0.00037658 6521600.0 69986.0 73061.0 79125.0 75284.0 83354.0 64101.0 67417.0 68601.0 51555.0 75750.0 True False 66096.45829615569 78664.543771858 74034.1836447861 65030.189327856286 72882.3253257854 72930.33089905774 70552.02408425123 68800.61755249309 61867.44056705672 73562.90067786386 0.8985026105155349 1.0693507603286951 1.0064065305008296 0.8840079541265943 0.9907483888508049 0.991400967430904 0.9590707195356878 0.935262434168752 0.841014152473103 1.0 16.166690747704173 -7.7824269792267815 3.2264165932645286 0.9125674281732393 0.9755436243101495 0.10337804585844446 0.06130120852752826 0.4631674869576335 9.862071748156959 0.03609090815696024 0.01664261151745263 1.650338460199035e-08 7.7824269792267815 0.06297619613691019 ETEAAYES(ph)DIPEELCGHHLPQQSLK ddPTM_A459_Selumetinib_30min_R2 1 ETEAAYESDIPEELCGHHLPQQSLK 25 0 Q8IYB7;Q8IYB7-4;Q8IYB7-5;Q8IYB7-3;Q8IYB7-2 Q8IYB7 DIS3L2 DIS3-like exonuclease 2 1 ET(0.002)EAAY(0.019)ES(0.978)DIPEELCGHHLPQQSLK 62.847 0.0020528 3281900.0 16599.0 13713.0 16731.0 19987.0 16410.0 16395.0 19154.0 16589.0 15693.0 15715.0 True False 15676.49403106177 14764.743005755332 15654.545675335448 17264.736120501864 14348.429092738652 18653.262431008105 20044.69895293096 16637.271243543204 18832.038499055783 15261.26711752645 1.027207892394365 0.9674650795410759 1.025769718515532 1.1312780247896046 0.9401859611159371 1.222261709159536 1.3134360861760352 1.0901631637412672 1.2339760751208242 1.0 13.897587131255246 -6.771492673367353 24.999850221351473 1.1864444179728888 1.0222351546406294 0.40394992432932286 0.0923905085866754 196.1633873176798 487802.94884920557 0.031351796469637705 0.027968144591341476 1.6924167955971416e-07 6.771492673367353 -0.16420926333225938 ETEEQDS(ph)DSAEQGDPAGEGK ddPTM_A459_Selumetinib_30min_R1 1 ETEEQDSDSAEQGDPAGEGK 20 0 H0Y626;O95361 H0Y626 TRIM16 Tripartite motif-containing protein 16 1 ET(0.003)EEQDS(0.975)DS(0.022)AEQGDPAGEGK 182.4 8.5769e-17 0.0 1956.7 2221.7 1426.4 1258.0 1719.0 1578.4 1477.3 1790.5 927.56 1722.4 True False 2002.2873029245782 1961.5823311596914 1232.702714654353 1038.3139155846607 1563.5167535141004 1562.5227290725352 1365.866071618947 1743.0101236363334 1574.0015736980067 1943.4868175967492 1.0302551500712207 1.0093108496538805 0.6342737720128567 0.5342531300873987 0.8044905369862466 0.8039790725232181 0.7027915287369592 0.896846897984974 0.8098853871539836 1.0 10.92443160677074 -9.834491671696824 13.080157765720374 0.9999999999981852 0.7960060225521043 0.13883144897011102 0.14636581495505493 0.0 0.0 0.15376946638954844 0.037294573642292536 1.46388960974609e-10 9.834491671696824 -0.20399397744608094 ETEEQDSDS(ph)AEQGDPAGEGK ddPTM_A459_Selumetinib_30min_R2 2 ETEEQDSDSAEQGDPAGEGK 20 0 H0Y626;O95361 H0Y626 TRIM16 Tripartite motif-containing protein 16 1 ETEEQDS(0.014)DS(0.986)AEQGDPAGEGK;ET(0.022)EEQDS(0.443)DS(0.536)AEQGDPAGEGK 195.36 1.1534000000000002e-15 50394000.0 450700.0 362688.0 427790.0 405130.0 475950.0 393906.0 476870.0 497340.0 399710.0 394442.0 True False 425651.8982950506 390505.00337427255 400266.4571425345 349950.59511176933 416156.9059530145 448162.9759773515 499045.3998999788 498787.17706093134 479663.16883053514 383053.43457660597 1.1112076276395466 1.0194530791922096 1.0449363483320657 0.9135816664810077 1.0864199831885029 1.1699750883912892 1.302808837758054 1.3021347207400644 1.2522095497217332 1.0 18.547186131395286 -6.77927323217469 2.768200171171967 1.2382729976965723 1.0225393828850837 0.45474777853766934 0.09355593422419349 0.2076190945653618 3.2625747274184786 0.03383275407954138 0.031068500442948937 1.66236645951739e-07 6.77927323217469 -0.21573361481148856 ETEPLVS(ph)PHQDK ddPTM_A459_Selumetinib_30min_R1 2 ETEPLVSPHQDK 12 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 ETEPLVS(1)PHQDK;ET(0.001)EPLVS(0.999)PHQDK 108.66 0.0079662 4493800.0 3489.0 3799.5 3440.3999999999996 3978.6000000000004 3520.6 2881.3999999999996 3813.5 3581.4 1977.8899999999999 3222.8999999999996 True False 3570.2869115878016 3354.6527736603716 2973.212576764466 3283.8121975716504 3202.1623516124155 2852.4157321018743 3525.844624733537 3486.4096379732837 3356.3348706299857 3636.5906087044573 0.9817676213104789 0.9224719344626678 0.8175824272459635 0.9029919919255126 0.8805396857011607 0.7843653682859982 0.9695467552201665 0.9587028107118508 0.9229344822582839 1.0 11.828370807366342 ETEPLVS(ph)PHQDK ddPTM_A459_Selumetinib_30min_R2 3 ETEPLVSPHQDK 12 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 ET(0.001)EPLVS(0.999)PHQDK;ETEPLVS(1)PHQDK;ETEPLVS(1)PHQDK 89.992 0.02296 14683400.0 111651.0 92939.0 105621.0 106021.0 110398.0 102018.0 102299.0 122195.0 98078.0 105128.0 True False 105445.88439436581 100067.12245401388 98825.45985144984 91580.75690357387 96528.81626935782 116070.05347280165 107056.10620162301 122550.56721952873 117696.34052828618 102092.68148465295 1.0328446942616247 0.9801596059464501 0.9679974941818503 0.8970354737654797 0.9455018211454118 1.1369086577498686 1.0486168513236298 1.2003854285867799 1.1528381742620684 1.0 16.63951992474432 -6.760575495393906 24.99999964864572 1.1165781154296277 0.9619894199933038 0.5792976640576328 0.06069478547702861 16.066589076910027 464958.3602857774 0.020841634518488764 0.019697164998987476 1.7354995468328473e-07 6.760575495393906 -0.15458869543632392 ETERAS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 1 ETERASPIK 9 1 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ETERAS(1)PIK 126.12 0.02317 195600000.0 8532.5 12308.0 7421.2 8064.6 7309.4 7862.5 9789.3 8855.1 5118.8 8395.9 True False 8731.29064864515 10866.973638166035 6413.441801733656 6656.2690012909825 6648.266060579385 7783.410388578814 9050.88521958935 8620.233982581452 8686.229737639993 9473.59554799149 0.9216448606459966 1.1470801749046546 0.6769807481482971 0.7026127479869232 0.7017679852280472 0.8215898967978409 0.9553801588572399 0.9099221028502784 0.9168883866360088 1.0 13.20969636555729 -7.256701919019845 23.134700369433666 0.9380411772922141 0.824703210860485 0.16005657460766576 0.13059595031530197 322.0098929827473 1572498.0106179242 0.057002839927753624 0.04259853462071516 5.537300352053077e-08 7.256701919019845 -0.11333796643172911 ETERAS(ph)PIKMDLAPSK ddPTM_A459_Selumetinib_30min_R1 2 ETERASPIKMDLAPSK 16 2 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ET(0.12)ERAS(0.88)PIKMDLAPSK;ET(0.058)ERAS(0.939)PIKMDLAPS(0.003)K 88.471 0.01573 837520000.0 5632.4 7730.299999999999 10558.099999999999 10810.0 8199.9 6846.0 7414.6 7681.2 4086.7 5737.1 True False 5763.623961257417 6825.23288228103 9124.368011491959 8922.236428831633 7458.220492809927 6777.135455670665 6855.310752471295 7477.469623946053 6934.831419241494 6473.512669086341 0.8903394889116489 1.0543322043493166 1.4094925704037828 1.3782681652017066 1.1521133693652856 1.0469023236849826 1.0589785025382272 1.1550868911795007 1.0712625082759377 1.0 12.660333047126757 -6.560358066565329 7.203773744707755 1.0776559105912102 1.1992129684427666 0.12551932735332982 0.14354913722617568 0.4628793368670297 69.13180152491849 0.05223570629608998 0.05255564339760825 2.751958836196389e-07 6.560358066565329 0.12155705785155635 ETERAS(ph)PIKMDLAPSK ddPTM_A459_Selumetinib_30min_R2 4 ETERASPIKMDLAPSK 16 2 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 ET(0.046)ERAS(0.954)PIKMDLAPSK;ET(0.048)ERAS(0.952)PIKMDLAPSK;ET(0.068)ERAS(0.932)PIKMDLAPSK;ET(0.023)ERAS(0.977)PIKMDLAPSK 84.046 0.019844 271318900.0 880203.0 927975.0 1002837.0 979120.0 893406.0 689178.0 628449.0 640359.0 437029.0 903799.0 True False 831284.8409917859 999147.6985900833 938315.5592263686 845762.1669237916 781168.3511290237 784106.0137650082 657673.1237480697 642222.3386728613 524447.0116105174 877703.9745181851 0.9471129960965701 1.138365243405175 1.0690569787398492 0.9636075390772522 0.8900134599001279 0.8933604455823987 0.7493108643026242 0.7317072239822188 0.5975215184577604 1.0 19.74337491475923 -6.578493041453033 1.0743664254013696 0.7482080018641832 1.0585337137862532 0.5311690298285846 0.10701918954019822 0.35054532031740593 0.8649027158539652 0.05194530607179274 0.05655936238288411 2.639410612370181e-07 6.578493041453033 0.3103257119220699 ETES(ph)APGSPR ddPTM_A459_Selumetinib_30min_R1 1 ETESAPGSPR 10 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1 Q6PKG0 LARP1 La-related protein 1 1 ETES(1)APGSPR 168.85 0.00025321 36121000.0 2002.0 2772.5 2492.0 2547.5 3341.6 1979.5 2862.8 2135.8 1198.1 1508.7 True False 2048.642704786121 2447.894411099719 2153.6000875761697 2102.6269474975547 3039.3528700073957 1959.5880272421969 2646.856691146496 2079.15164594386 2033.0881942381964 1702.3563409824753 1.2034159097406096 1.4379447781696362 1.2650700888706237 1.2351273918855747 1.785379944749584 1.1511033148977883 1.5548194155513435 1.2213375048986077 1.1942788623590093 1.0 10.733317341403447 -8.397299802556848 1.6186298019100895 1.0099961886848599 1.3747282155552718 0.28876495231086896 0.18158672384836733 0.44191208844562274 2.4240559613578885 0.16405266336347 0.04830884579926625 4.005900864478437e-09 8.397299802556848 0.36473202687041195 ETES(ph)APGSPR ddPTM_A459_Selumetinib_30min_R2 1 ETESAPGSPR 10 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1 Q6PKG0 LARP1 La-related protein 1 1 ET(0.011)ES(0.986)APGS(0.003)PR 80.834 0.046595 26659000.0 22674.0 25094.0 25932.0 26148.0 27699.0 22828.0 19630.0 19594.0 17224.0 22698.0 True False 21413.86985121361 27018.62911007249 24263.563352626807 22586.59729218407 24219.203987798173 25972.349788048374 20542.833896107066 19651.01529603868 20669.28127876995 22042.64976351354 0.9714743953632686 1.225743247746717 1.100755290899258 1.0246770481092935 1.0987428574892757 1.1782771158048129 0.9319584585565993 0.8914996838794921 0.9376949459580455 1.0 14.428010041339665 -7.278936653418323 23.996912918144606 0.9312465378804773 1.1022240099741847 0.5462813757592301 0.07107270239645684 357.8358181197305 490756.7960176544 0.0290819170099279 0.019666403824154858 5.2609399733567566e-08 7.278936653418323 0.1709774720937074 ETESAPGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 ETESAPGSPR 10 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1 Q6PKG0 LARP1 La-related protein 1 1 ETESAPGS(1)PR;ETES(0.009)APGS(0.991)PR;ETESAPGS(1)PR 160.86 0.00043512 216043000.0 13630.6 13066.5 14821.9 15993.2 17188.2 11442.7 13071.099999999999 11468.900000000001 5572.01 9114.6 True False 13948.166459469394 11536.668105548952 12809.16739086887 13200.287849545799 15633.530344823172 11327.596827140322 12085.13640339701 11164.707515762493 9455.294006491258 10284.547693722327 1.3562255604087805 1.1217477373935383 1.2454769788940323 1.2835068923452255 1.5200989688993183 1.1014190574520522 1.1750770926730945 1.0855808002696525 0.9193689686774223 1.0 13.328190726220011 -7.653882334504019 1.316964578539885 0.9660082857785787 1.2805869018459797 0.565618650492179 0.1103932819903802 0.3573545500806359 1.1540030213253551 0.08951132994634513 0.03750526551309507 2.2187974878627582e-08 7.653882334504019 0.314578616067401 ETESAPGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 ETESAPGSPR 10 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1 Q6PKG0 LARP1 La-related protein 1 1 ETESAPGS(1)PR;ETESAPGS(1)PR;ETESAPGS(1)PR 128.08 0.0031781999999999995 706146600.0 63023.0 62804.0 75490.0 75736.0 79004.0 49706.0 56815.0 64584.0 63123.0 64763.0 True False 59520.43396105827 67620.86485331132 70633.05558729729 65420.62614811267 69078.81121527869 56552.550313857166 59457.01007678675 64771.92874754321 75749.3638039826 62893.12391551801 0.9463742656670998 1.075171030527024 1.1230648310962585 1.0401872585624743 1.0983523621448616 0.8991849473055608 0.9453658265830958 1.0298729768066368 1.2044140772166747 1.0 15.940614675902927 -11.881511104484076 2.1488118149661553 0.7749898069580476 1.0381518173235034 0.018246298787045312 0.08732967665515655 18585585.96503549 2258938.7312525813 20297656.534797154 0.02362777099054395 1.313677905074664e-12 11.881511104484076 0.2631620103654557 ETFAS(ph)DTNEALASLDESQEGHAEAK ddPTM_A459_Selumetinib_30min_R1 2 ETFASDTNEALASLDESQEGHAEAK 25 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 ET(0.041)FAS(0.782)DT(0.177)NEALASLDESQEGHAEAK;ET(0.015)FAS(0.974)DT(0.011)NEALASLDESQEGHAEAK 236.7 5.3523e-45 13944600.0 3989.3999999999996 4313.0 2567.1000000000004 2511.5 3854.1000000000004 3035.3 3893.7000000000003 3909.9 1465.91 3462.0 True False 4082.345257978898 3808.0319549406995 2218.50192007094 2072.91367169386 3505.497335496623 3004.7676378318943 3599.9950741641446 3806.1967508549014 2487.5422041696966 3906.381422735684 1.045045226310744 0.9748233832921238 0.5679173844005477 0.5306480467138242 0.8973771263333734 0.7691946363311397 0.9215677335581395 0.9743535868520945 0.6367893799852351 1.0 11.931617106857507 -7.252597567613001 23.746357774643286 0.8810404731401384 0.7875356040749988 0.051653475639272695 0.17668407294961264 1148.050471468106 3083312.0323376246 0.07289394058905257 0.05553538056775665 5.589879325024221e-08 7.252597567613001 -0.09350486906513966 ETFAS(ph)DTNEALASLDESQEGHAEAK ddPTM_A459_Selumetinib_30min_R2 2 ETFASDTNEALASLDESQEGHAEAK 25 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 ET(0.023)FAS(0.852)DT(0.125)NEALASLDESQEGHAEAK;ET(0.202)FAS(0.741)DT(0.056)NEALASLDESQEGHAEAK 154.66 3.7613e-11 9358400.0 44315.0 33997.0 40589.0 53932.0 52131.0 36123.0 44666.0 48660.0 43829.0 41697.0 True False 41852.149707000535 36604.46058241553 37977.54792996177 46586.36856211072 45581.83772294688 41098.615358054616 46743.05750399994 48801.59254390332 52596.02468458011 40493.09926818329 1.033562519623809 0.9039678672157558 0.9378770362436035 1.1504767331730301 1.1256692756724103 1.0149535624789061 1.154346255257558 1.2051829429180858 1.2988885917632507 1.0 15.305388448044717 -5.762221146430788 24.99093920711912 1.1395293540749492 0.9530189824358025 0.4692301414773271 0.08622492603004359 17.715864545176146 566364.182259976 0.024742956263385622 0.03927661301693265 1.7289357462917772e-06 5.762221146430788 -0.18651037163914663 ETFASDTNEALAS(ph)LDESQEGHAEAK ddPTM_A459_Selumetinib_30min_R1 1 ETFASDTNEALASLDESQEGHAEAK 25 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 ETFASDTNEALAS(1)LDESQEGHAEAK 185.21 5.6423e-22 5756900.0 1473.3 1558.3 1102.9 1164.0 1373.2 1089.5 1451.4 1235.6 459.55 1322.9 True False 1507.6250234572394 1375.8535115659834 953.1322377960502 960.729250986125 1248.994302458151 1078.540619186852 1341.9197294711562 1202.8278742055586 779.8227857959795 1492.7071011372154 1.0099938710740097 0.9217170002861195 0.638525962038975 0.6436153819153105 0.8367309980012875 0.7225400203195712 0.8989839523432412 0.8058030093708183 0.5224218369443498 1.0 10.543715392403918 -5.067426169682883 5.437264406761767 0.7544541314372509 0.9913831244350471 0.29531614318913235 0.13103903713056322 0.22264043439509568 12.549493677035926 0.03266303815971245 0.09469963197049441 8.561972533848407e-06 5.067426169682883 0.23692899299779613 ETFASDTNEALAS(ph)LDESQEGHAEAK ddPTM_A459_Selumetinib_30min_R2 1 ETFASDTNEALASLDESQEGHAEAK 25 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 ETFASDTNEALAS(0.995)LDES(0.005)QEGHAEAK 104.32 0.00010771 0.0 11802.0 8970.3 10813.0 13696.0 12551.0 10662.0 10613.0 10090.0 9172.9 10718.0 True False 11146.092087149284 9658.2931659394 10117.303352304245 11830.581173082179 10974.23117263637 12130.59372000051 11106.52552926054 10119.360229510577 11007.736312240419 10408.543491291668 1.0708599235305774 0.9279197588039126 0.9720191264771013 1.1366221588044727 1.0543483996409282 1.1654458407316644 1.0670585695830392 0.972216740793461 1.057567403301919 1.0 13.345480580280427 -4.445640920904122 22.963455115568447 1.0419436653740501 2.788000676959909 0.016485246082257543 0.07053903100837047 5326.562190010742 1425043.5734766817 0.018226785024104117 48431.92395567709 3.583926373136817e-05 4.445640920904122 1.7460570115858587 ETFASDTNEALASLDES(ph)QEGHAEAK ddPTM_A459_Selumetinib_30min_R1 1 ETFASDTNEALASLDESQEGHAEAK 25 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 ETFASDTNEALASLDES(1)QEGHAEAK 171.87 1.4060999999999998e-16 14854000.0 3810.4 4339.0 3212.8 2811.2 3062.1 3107.6 4034.4 3737.5 1969.1 3427.1 True False 3899.174906252266 3830.9878628536258 2776.5194066471586 2320.276692759619 2785.133595657666 3076.3403654750414 3730.0819598859275 3638.3693588890233 3341.4188826261857 3867.0016677809 1.0083199442967472 0.9906868918037108 0.7180031572731334 0.6000195738449532 0.720230771779297 0.7955363430811283 0.9645927983337167 0.9408760769883302 0.8640851930492384 1.0 11.916999671296077 -7.254606128157559 23.72274104984573 0.937461526381281 0.7966968260760998 0.2368427106232741 0.11965886705616566 453.7129883552241 1575143.1163908604 0.05300711350902939 0.04005875951621397 5.5640864855536686e-08 7.254606128157559 -0.14076470030518118 ETFASDTNEALASLDES(ph)QEGHAEAK ddPTM_A459_Selumetinib_30min_R2 2 ETFASDTNEALASLDESQEGHAEAK 25 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 ETFASDTNEALASLDES(1)QEGHAEAK;ETFASDTNEALASLDES(1)QEGHAEAK 171.14 1.6954e-16 16111000.0 64541.0 58133.0 71799.0 77601.0 77697.0 67230.0 64551.0 66150.0 52460.0 69536.0 True False 60954.06959809371 62591.61417294351 67179.53050884062 67031.60993080845 67936.00824000708 76490.32224682378 67552.74940537999 66342.48554827795 62953.465854869464 67528.3150037746 0.9026446105561288 0.9268943578622517 0.9948349889240612 0.9926444918263045 1.0060373672319485 1.1327148062638352 1.000361839349968 0.9824395225109592 0.9322528757211044 1.0 16.043204938750414 -5.2035255248231325 1.717139357478932 1.0115991505654915 0.8953001940500596 0.37339151104583024 0.04735147757591446 0.5359327281661148 2.601357057422082 0.014786835682723078 0.07755379798352915 6.258560793527834e-06 5.2035255248231325 -0.11629895651543198 ETFLTSPEELYR ddPTM_A459_Selumetinib_30min_R2 1 ETFLTSPEELYR 12 0 O95433-2;O95433;H0YJ63;G3V438;H0YJG7 O95433-2 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 139.15 0.016366 2278700.0 8259.1 8088.0 9761.9 11808.0 10933.0 7662.1 8200.3 9217.9 7102.6 7182.5 False True 7800.092285796865 8708.323592981049 9133.82998195309 10199.730030063844 9559.498797739894 8717.484725381344 8581.630198586186 9244.722562894503 8523.318463225236 6975.122562623845 1.1182731508681463 1.248483236645124 1.3094866649220855 1.4623011909093957 1.3705133797883946 1.2497966375664762 1.2303196282988351 1.3253849634746633 1.2219596697694446 1.0 12.768002851989019 -8.667929622662939 3.3496077663596067 1.0000320591410967 1.2934936234914076 0.5028094364086446 0.08627576104547408 0.6377563191424065 13.051278352901427 0.09017546210091265 0.0238203077174754 2.1481785578474557e-09 8.667929622662939 0.2934615643503109 ETFS(ph)SAEGTVDKDTTIMELR ddPTM_A459_Selumetinib_30min_R2 1 ETFSSAEGTVDKDTTIMELR 20 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 ET(0.069)FS(0.71)S(0.218)AEGT(0.003)VDKDTTIMELR 57.152 0.021655 6429600.0 10444.0 6781.5 9357.7 10124.0 8295.3 7887.2 8745.3 8206.8 5970.5 6303.9 True False 9863.564290644566 7301.619244040671 8755.635769893404 8745.09373512588 7253.170253077079 8973.590207127001 9151.973778483196 8230.680429291118 7164.766829708317 6121.890027500793 1.6111959290897748 1.1927066986241652 1.4302177482054206 1.42849572531377 1.1847926409155247 1.4658202232996318 1.4949588668484148 1.344467213935109 1.170352096741808 1.0 12.579761413453115 -8.436461183341637 2.3184002879523518 1.0042359879503078 1.390922038544834 0.5273027157533511 0.12278774148714128 0.21810511292387333 2.4801429389496636 0.11326777933086664 0.031301137439280896 3.660486560339661e-09 8.436461183341637 0.3866860505945262 ETGEHLVHVK ddPTM_A459_Selumetinib_30min_R1 2 ETGEHLVHVK 10 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 0 ; 111.46 0.0049849 21852000.0 13219.1 15176.2 14599.9 15673.3 14657.2 13834.7 14551.1 13674.3 7552.1 12477.2 False True 13527.079310109006 13399.363448776037 12617.313771510162 12936.25237927907 13331.45884793884 13695.535478902559 13453.498811842184 13311.613143613691 12815.362116439606 14078.77015822001 0.9608139885862903 0.9517424674308433 0.896194314539856 0.9188481830372186 0.9469192761950982 0.9727792502462513 0.9555876444212881 0.9455096570236706 0.9102614768490448 1.0 13.781233693344927 -6.507743379958833 22.919217325738618 0.9540672158821396 0.9310313104871571 0.1582593722248984 0.02670665084479822 490.55569276901196 742842.1628350359 0.008695737907102357 0.009525194806401922 3.1063945818190644e-07 6.507743379958833 -0.02303590539498246 ETGEHLVHVK ddPTM_A459_Selumetinib_30min_R2 4 ETGEHLVHVK 10 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 0 ;;; 123.21 0.0023829 45823600.0 351135.0 335160.0 356715.0 375987.0 426755.0 318258.0 303406.0 306839.0 304528.0 365074.0 False True 331620.32240477577 360865.6942907428 333764.3452619261 324776.92198624805 373142.22166189377 362095.15064152377 317514.9801875832 307731.85069006874 365442.10922325077 354533.3650438348 0.9353712657305864 1.0178610248604532 0.9414187158962013 0.9160687089241725 1.0524883084438559 1.0213288405077305 0.895585610534358 0.8679912274322067 1.0307693020036837 1.0 18.435561879950107 -9.815674338966488 8.63237757221288 0.9999999702083653 0.9632173955788835 0.03054945851112567 0.0600092423573449 0.0 0.0 0.05998066037008536 0.014547446952950663 1.5287119519234915e-10 9.815674338966488 -0.03678257462948176 ETGTDGILAGSQEHDPGQGS(ph)SSPEQAGSPTEGEGVSTWESFKR ddPTM_A459_Selumetinib_30min_R1 1 ETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKR 43 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 ETGTDGILAGS(0.184)QEHDPGQGS(0.627)S(0.145)S(0.035)PEQAGS(0.009)PT(0.001)EGEGVSTWESFKR 88.087 3.3416e-12 18619000.0 602.62 783.91 416.87 408.64 608.59 601.79 554.32 603.56 269.83 380.14 True False 616.6598735056009 692.1294527701281 360.2613437030007 337.27869512282695 553.5431419552914 595.736538981602 512.5071961144079 587.5516281608182 457.8818023965382 428.9346718771644 1.4376545286182787 1.613601086946722 0.8398979316043028 0.7863171649118043 1.2905068726032283 1.3888747588868389 1.1948374186481627 1.3697928068847682 1.0674861055010807 1.0 8.744614127160013 -1.5228787452807617 0.02003392485031025 3.773484424820936e-14 2.745326266997567 0.08183124741299741 0.24591174586258802 11868.817078963322 18.393835598327588 934.6900279220949 1688.367745052705 0.0299999999999707 1.5228787452807617 2.7453262669975294 ETHQQVVSR ddPTM_A459_Selumetinib_30min_R2 2 ETHQQVVSR 9 0 J3QRP6;O14745 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 ; 139.38 0.0033506 2293700.0 14583.3 10799.0 9047.7 11515.400000000001 11226.0 12514.0 18563.9 26409.0 14796.199999999999 20747.9 False True 13772.81856757534 11627.248575742124 8465.580832390922 9946.982654826994 9815.68951828666 14237.689909218376 19427.15813367 26485.84581775469 17755.85344037018 20148.854217481836 0.6835534377744205 0.5770674823610528 0.42015197196900134 0.4936748535406371 0.48715869460062056 0.7066252877478894 0.9641817804614583 1.314508782081249 0.8812339028670223 1.0 14.29841018049842 -7.185695372640565 2.4891996095481552 1.081092591170191 0.5288628122071327 0.7940507163101186 0.12210755964795082 0.12195189261009097 1.4792033710408612 0.05434319796861771 0.03820769171620581 6.520856263764378e-08 7.185695372640565 -0.5522297789630582 ETHVMDYR ddPTM_A459_Selumetinib_30min_R1 2 ETHVMDYR 8 0 H0YM70;A0A087X1Z3;Q9UL46 H0YM70 PSME2 Proteasome activator complex subunit 2 0 ; 145.16 0.0028552 15345100.0 8439.5 10900.400000000001 10232.7 12415.3 10176.1 9892.400000000001 9777.0 9103.2 4843.5 7538.3 False True 8636.123929591651 9624.17610054152 8843.155544197698 10247.200919044708 9255.673551736378 9792.89143758055 9039.513018492142 8861.753564639073 8219.065744756448 8505.914234260083 1.0153081364031524 1.1314687446268041 1.0396478615525273 1.2047148180463751 1.0881456474668434 1.1513038067250652 1.0627326786440936 1.0418343426207781 0.9662765833743929 1.0 13.054250592902102 -7.843969166780307 2.0044704879056168 0.9857218614733628 1.1065675115786886 0.4490130518840696 0.05210976468738813 0.2971505063682346 2.2907034215918882 0.037842825376067535 0.014450159913264843 1.4322895826556127e-08 7.843969166780307 0.12084565010532577 ETIELS(ph)PTGRPK ddPTM_A459_Selumetinib_30min_R1 2 ETIELSPTGRPK 12 1 A0A087WSW7;F6XU50;A0A0B4J1V9;Q9NRZ9-6;Q9NRZ9-5;Q9NRZ9-3;Q9NRZ9-2;Q9NRZ9;Q9NRZ9-4 A0A087WSW7 HELLS Lymphoid-specific helicase 1 ETIELS(0.9)PT(0.1)GRPK;ETIELS(0.854)PT(0.146)GRPK 79.885 0.022654 61244000.0 8683.400000000001 11590.4 8160.5 9198.3 8005.6 8959.3 10353.5 9601.3 4475.8 8338.3 True False 8885.706325044863 10233.39057976923 7052.348922417873 7591.989578475666 7281.494893503481 8869.177576393542 9572.527159349333 9346.642334582246 7595.105700501898 9408.602026919973 0.9444236560990681 1.087663241626053 0.7495639524596356 0.8069200457999394 0.7739188959921576 0.9426668862193316 1.0174229000185506 0.993414569756437 0.8072512450596504 1.0 13.199764661318477 -6.9730915402687845 24.88694143317416 0.9576979459698657 0.8724100917081269 0.12665781662216535 0.10481742632898941 473.0262049962377 437488.28058161057 0.0397046614919547 0.035015487555828693 1.0639187425853536e-07 6.9730915402687845 -0.0852878542617388 ETIELS(ph)PTGRPK ddPTM_A459_Selumetinib_30min_R2 3 ETIELSPTGRPK 12 1 A0A087WSW7;F6XU50;A0A0B4J1V9;Q9NRZ9-6;Q9NRZ9-5;Q9NRZ9-3;Q9NRZ9-2;Q9NRZ9;Q9NRZ9-4 A0A087WSW7 HELLS Lymphoid-specific helicase 1 ETIELS(0.574)PT(0.426)GRPK;ETIELS(0.959)PT(0.041)GRPK;ETIELS(0.971)PT(0.029)GRPK 93.716 0.010953 64076000.0 212138.0 190353.0 215002.0 240467.0 233469.0 176836.0 241889.0 223215.0 173130.0 200268.0 True False 200348.21921569842 204952.4630186351 201169.00539647782 207714.97977128736 204138.53698065793 201193.5538426198 253137.3177939605 223864.5186947673 207760.83765637688 194485.74248124677 1.0301434781781855 1.0538174182017357 1.0343637679038373 1.0680216303841203 1.0496324017188146 1.0344899902470734 1.3015726220567 1.1510587657414186 1.0682574208564937 1.0 17.56930487126506 ETIEQEKR ddPTM_A459_Selumetinib_30min_R2 1 ETIEQEKR 8 1 P63313 P63313 TMSB10 Thymosin beta-10 0 93.143 0.033116 34698000.0 103260.0 89904.0 69280.0 79916.0 76813.0 67797.0 88209.0 120480.0 74771.0 123320.0 False True 97521.22258253125 96799.3477130771 64822.60022636068 69031.30293721044 67163.06422306725 77135.42135011012 92310.89328281765 120830.57685346223 89727.28927629515 119759.43117616065 0.8143093335094586 0.8082816256090068 0.5412734478590634 0.5764164229844123 0.560816493226938 0.644086403822739 0.7708027031877978 1.0089441446638634 0.7492294209740393 1.0 16.869779748563673 -7.514612257540971 4.027441078454834 0.9094183479810888 0.6529391041193296 0.5286796389298318 0.1103062767715562 0.18349421238443503 6.87307047665878 0.05581875841538977 0.033198863406685576 3.057649795269244e-08 7.514612257540971 -0.25647924386175913 ETIQGTGSWGPEPPGPGIPPAYS(ph)SPRR ddPTM_A459_Selumetinib_30min_R1 1 ETIQGTGSWGPEPPGPGIPPAYSSPRR 27 1 Q9H4L4 Q9H4L4 SENP3 Sentrin-specific protease 3 1 ETIQGTGSWGPEPPGPGIPPAY(0.002)S(0.499)S(0.499)PRR 115.76 4.3443e-12 10558000.0 338.18 368.22 333.71 500.72 443.49 323.12 440.41 389.33 159.09 205.01 True False 346.058936016269 325.1086312191662 288.39401493781827 413.278651678499 403.37640780451915 319.8697061694865 407.18951912387456 379.0037036779299 269.9641105261284 231.32503046650578 1.4959856930241533 1.4054191652478336 1.2467047528588813 1.7865712622842982 1.7437646371040905 1.382771702329037 1.7602484188706622 1.6384033449108608 1.167033718667195 1.0 7.853777570647747 -8.406247262300862 3.92322311461878 1.0079566063693581 1.5560471734080634 0.559458877186341 0.17080488071709335 0.16980517291042224 4.276048862487253 0.17370328842575475 0.04578572696455094 3.924214495811918e-09 8.406247262300862 0.5480905670387053 ETIQGTGSWGPEPPGPGIPPAYS(ph)SPRR ddPTM_A459_Selumetinib_30min_R2 3 ETIQGTGSWGPEPPGPGIPPAYSSPRR 27 1 Q9H4L4 Q9H4L4 SENP3 Sentrin-specific protease 3 1 ETIQGTGSWGPEPPGPGIPPAY(0.309)S(0.346)S(0.346)PRR;ETIQGTGSWGPEPPGPGIPPAY(0.294)S(0.353)S(0.353)PRR;ETIQGTGSWGPEPPGPGIPPAY(0.257)S(0.371)S(0.371)PRR 118.59 4.1989e-12 13217000.0 12698.9 9400.5 16124.0 17417.6 20639.0 13681.4 10638.9 14334.7 13285.7 14656.400000000001 True False 11993.14597572445 10121.488122628376 15086.59939448382 15045.2928329641 18046.144304998958 15565.888662616306 11133.629930580415 14376.411603762663 15943.211233473881 14233.231650099557 0.842615807186737 0.7111166579346426 1.0599560075577281 1.0570538864839498 1.267888048802517 1.0936299671977465 0.7822278316184462 1.0100595533876597 1.1201399390813935 1.0 13.796975641993418 -5.268671297591461 24.67134992103101 1.0494187597152154 0.7768662271290613 0.46014124573524384 0.11784848438914679 393.99056809337804 1344084.8673506798 0.033428706096502524 0.0719883875942316 5.386773344298645e-06 5.268671297591461 -0.2725525325861541 ETIQGTGSWGPEPPGPGIPPAYSS(ph)PRR ddPTM_A459_Selumetinib_30min_R1 1 ETIQGTGSWGPEPPGPGIPPAYSSPRR 27 1 Q9H4L4 Q9H4L4 SENP3 Sentrin-specific protease 3 1 ETIQGTGSWGPEPPGPGIPPAY(0.079)S(0.252)S(0.669)PRR 123.98 3.9216e-12 15246000.0 866.68 820.21 981.17 1025.2 1023.7 875.31 933.84 853.17 620.2 837.36 True False 886.8719577342841 724.1794318947158 847.9325031810235 846.168065387436 931.1065157489143 866.505176117892 863.3996969611022 830.5411601132697 1052.4341023842162 944.8433125771102 0.9386444777973756 0.7664545245279644 0.8974318724532672 0.895564432878789 0.9854612964442453 0.9170887538532217 0.913801987555094 0.8790252828777766 1.1138715683065443 1.0 9.883931290631676 -6.999801335526944 0.3615395898115444 1.0230748336636155 0.8384821356281908 0.335715518601142 0.07005292153608493 1.8942518548611904 0.5581622221269673 0.08175949886360602 0.12866384491122446 1.0004575464966472e-07 6.999801335526944 -0.18459269803542466 ETLS(ph)PPGNGCAIYR ddPTM_A459_Selumetinib_30min_R2 2 ETLSPPGNGCAIYR 14 0 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;Q6W2J9-3 H7BYY2 BCOR BCL-6 corepressor 1 ET(0.231)LS(0.769)PPGNGCAIYR;ET(0.022)LS(0.978)PPGNGCAIYR 115.09 0.0038843 0.0 31607.0 30513.0 33723.0 34253.0 34702.0 30083.0 31070.0 30434.0 32801.0 32671.0 True False 29850.409472845924 32853.24898524118 31553.298894826203 29587.682310279226 30342.42452018384 34226.66018371558 32514.816564037043 30522.557901380093 39362.11653651496 31727.703340547687 0.9408310823020524 1.0354751692113515 0.9945030863454085 0.9325503958701752 0.9563385094251851 1.0787626137431212 1.0248083895339324 0.9620159887959041 1.2406229380684661 1.0 14.95345547284655 -7.422067604653873 0.9986509683957032 1.083227807265135 0.9788370676540111 0.22599170946218738 0.07601504707328631 0.8754150368837249 1.641028624654355 0.05848207748697825 0.02942453405962771 3.7838367885987e-08 7.422067604653873 -0.10439073961112377 ETMQS(ph)LNDR ddPTM_A459_Selumetinib_30min_R1 2 ETMQSLNDR 9 0 P05783;F8VZY9;CON__Q92764;C4AM86;CON__Q497I4;Q92764 P05783 KRT18;KRT35 Keratin, type I cytoskeletal 18;Keratin, type I cuticular Ha5 1 ETMQS(1)LNDR;ET(0.037)MQS(0.963)LNDR 105.36 0.013793 15314900.0 2197.3 3252.8 2953.0 3338.8 3229.4 2933.2 3351.9 3292.8 1681.67 2553.3 True False 2248.4928147984756 2871.960663814306 2551.9988196679096 2755.741257038209 2937.3013401968774 2903.694671132514 3099.0634843698263 3205.4642474781986 2853.6711656827883 2881.040926248131 0.7804445935888183 0.9968482702376429 0.8857905475821475 0.9565088895237961 1.0195278079655785 1.0078630416798293 1.075674925730964 1.1126062869410716 0.9905000445096123 1.0 11.492374439320178 -3.1036060928029343 0.3988754680630177 1.0537170760526433 8.285990667127814e-15 0.6166869223462568 0.0550477365550963 13.809675484434337 0.5958294588526089 0.041114519537572065 9.180758089861285 0.0007877599678682125 3.1036060928029343 -1.053717076052635 ETMQS(ph)LNDR ddPTM_A459_Selumetinib_30min_R2 1 ETMQSLNDR 9 0 P05783;F8VZY9;CON__Q92764;C4AM86;CON__Q497I4;Q92764 P05783 KRT18;KRT35 Keratin, type I cytoskeletal 18;Keratin, type I cuticular Ha5 1 ET(0.001)MQS(0.999)LNDR 104.07 0.011575 0.0 31973.0 25812.0 24868.0 28646.0 27029.0 19105.0 19031.0 25693.0 18095.0 24187.0 True False 30196.06865805998 27791.69740133864 23268.019954231175 24744.365382893717 23633.375377674154 21736.54033207746 19915.979209211087 25767.762376294875 21714.505616543334 23488.658464626944 1.2855595266768491 1.1831964538626978 0.990606593785335 1.0534601378004547 1.0061611399929522 0.9254057810415989 0.8478976881205804 1.0970299736402647 0.9244676808275186 1.0 14.519676696914077 -4.7431769262753765 0.9327350110978285 0.9661232512300301 1.4976795526978748 0.7103133034896338 0.06637056484291935 1.222900538899309 0.7974692614920406 0.02305941659818329 0.6741299305957811 1.8064380552551553e-05 4.7431769262753765 0.5315563014678447 ETMQSLNDR ddPTM_A459_Selumetinib_30min_R1 3 ETMQSLNDR 9 0 P05783;F8VZY9;CON__Q92764;C4AM86;CON__Q497I4;Q92764 P05783 KRT18;KRT35 Keratin, type I cytoskeletal 18;Keratin, type I cuticular Ha5 0 ;; 228.31 0.011853 1980152000.0 9184.0 10913.5 9030.599999999999 10122.400000000001 10138.5 8379.1 10550.3 9693.8 4828.5 8235.900000000001 False True 9397.969331046825 9635.742346451498 7804.294121535055 8354.712860981066 9221.474465097557 8294.813861614086 9754.482376904738 9436.688934099902 8193.611840313106 9293.05798945951 1.0112892162844898 1.0368753059951494 0.8397982806506685 0.8990273030101883 0.9922970969896943 0.8925817390811867 1.0496525888430472 1.0154557245637876 0.8816916723866963 1.0 13.181937695078448 -7.253599401191477 24.818873102668224 0.9879879741970183 0.9447093141598358 0.08027388381411271 0.06855851779494863 1546.0594534932918 4894338.235331561 0.02766192119841741 0.021006521375116355 5.576999413360521e-08 7.253599401191477 -0.043278660037182504 ETMQSLNDR ddPTM_A459_Selumetinib_30min_R2 5 ETMQSLNDR 9 0 P05783;F8VZY9;CON__Q92764;C4AM86;CON__Q497I4;Q92764 P05783 KRT18;KRT35 Keratin, type I cytoskeletal 18;Keratin, type I cuticular Ha5 0 ;;;; 274.96 5.6135e-27 1047350000.0 443653.0 449900.0 547930.0 538541.0 550586.0 381817.0 428313.0 420188.0 368330.0 459598.0 False True 418996.54234367405 484405.8833434921 512676.7803410776 465190.7867649561 481416.46437870833 434408.82596036774 448230.4031861081 421410.6775141321 442006.29200007854 446328.2115609877 0.938763294568085 1.0853131637127118 1.1486542124416526 1.0422616691380509 1.0786153595243353 0.9732945727115633 1.0042618673340582 0.9441721732988623 0.9903167233238659 1.0 18.767745473930006 -6.764496212445179 24.90635796720595 0.9802856158821599 1.0642806797961093 0.35245205819089476 0.05140368885756359 82.71430189180138 673931.9910231066 0.018016240225760174 0.01656705320762688 1.7199023407288353e-07 6.764496212445179 0.0839950639139494 ETNLDS(ph)LPLVDTHSK ddPTM_A459_Selumetinib_30min_R1 6 ETNLDSLPLVDTHSK 15 0 P08670 P08670 VIM Vimentin 1 ETNLDS(0.966)LPLVDT(0.034)HSK;ETNLDS(1)LPLVDTHSK;ETNLDS(1)LPLVDTHSK;ET(0.005)NLDS(0.933)LPLVDT(0.061)HSK;ET(0.001)NLDS(0.901)LPLVDT(0.098)HSK;ET(0.005)NLDS(0.995)LPLVDTHSK 222.51 1.3127e-09 686511100.0 33975.6 47404.4 35188.8 37353.6 37760.8 35572.5 41095.09999999999 36849.9 21452.7 34416.6 True False 34767.1653749907 41854.27081029232 30410.3542382425 30830.49497391353 34345.342307210696 35214.67294724578 37995.26352114517 35872.520946655386 36403.66505678472 38834.305856073086 0.8952693915489067 1.0777653903590234 0.7830796397120818 0.7938984435096351 0.884407266979374 0.9067929031037064 0.9783943006980077 0.9237327707003543 0.9374099589085805 1.0 15.245044058281874 -7.076698402959746 4.642250251955524 0.9532200234922735 0.8871534263742076 0.16428476830988004 0.07739850513777921 0.5112327182076867 20.18231981507221 0.032382186851458036 0.02521851375397022 8.381111087251463e-08 7.076698402959746 -0.06606659711806595 ETNLDS(ph)LPLVDTHSK ddPTM_A459_Selumetinib_30min_R2 9 ETNLDSLPLVDTHSK 15 0 P08670 P08670 VIM Vimentin 1 ET(0.001)NLDS(0.999)LPLVDTHSK;ETNLDS(1)LPLVDTHSK;ET(0.033)NLDS(0.967)LPLVDTHSK;ETNLDS(0.974)LPLVDT(0.026)HSK;ET(0.023)NLDS(0.977)LPLVDTHSK;ET(0.214)NLDS(0.786)LPLVDTHSK;ET(0.002)NLDS(0.998)LPLVDTHSK;ETNLDS(0.999)LPLVDT(0.001)HSK;ET(0.001)NLDS(0.999)LPLVDTHSK 200.71 1.8072e-05 408629200.0 374686.0 322451.0 386503.0 441007.0 415225.5 332483.0 361179.0 352229.0 292994.8 303158.0 True False 353862.4521068989 347181.9548566181 361635.81777264865 380941.08582049253 363061.1605269322 378279.51526983036 377974.53916261083 353253.92807535 351601.94695871737 294405.0408409215 1.2019578574339171 1.1792663395468626 1.228361500671636 1.2939353372904026 1.2332029352823082 1.2848948312479116 1.2838589247078998 1.1998908954355398 1.1942796426121711 1.0 18.167442848053 -10.207577187810044 6.015812621853379 0.9999999976636724 1.2353633987324684 0.7595023740388 0.039368170844326006 7603532.698658723 12901612.143812362 0.21894258239173756 0.01044286032673423 6.200444324325539e-11 10.207577187810044 0.23536340106879594 ETNLDS(ph)LPLVDTHSKR ddPTM_A459_Selumetinib_30min_R1 2 ETNLDSLPLVDTHSKR 16 1 P08670 P08670 VIM Vimentin 1 ET(0.004)NLDS(0.996)LPLVDTHSKR;ET(0.011)NLDS(0.989)LPLVDTHSKR 72.968 0.024695 78629900.0 14214.6 10860.1 30931.3 28353.7 22743.0 16873.4 16203.5 15736.9 10751.1 10434.6 True False 14545.772523203208 9588.594443276485 26730.999353468997 23402.258559867096 20685.899665602785 16703.668915821407 14981.256949487311 15319.506291344649 18243.831470723868 11773.98255161115 1.2354165176856633 0.8143883686972495 2.2703447398782775 1.9876247019463038 1.7569161135517504 1.418693194303713 1.2724035290367641 1.3011320701548288 1.549503865047548 1.0 13.523314774320331 -6.950645470380155 5.465439002410371 1.3103472456267602 1.624934709595518 0.1368555249883736 0.39110952122796894 0.46948120189837367 31.42351262542806 0.15425659001526995 0.13427292108860248 1.1203520924632245e-07 6.950645470380155 0.3145874639687578 ETNLDS(ph)LPLVDTHSKR ddPTM_A459_Selumetinib_30min_R2 2 ETNLDSLPLVDTHSKR 16 1 P08670 P08670 VIM Vimentin 1 ET(0.017)NLDS(0.983)LPLVDTHSKR;ET(0.016)NLDS(0.983)LPLVDT(0.001)HSKR 84.113 0.0089594 22778000.0 39068.0 44623.0 47875.0 53396.0 48727.0 30165.0 23495.1 22215.0 12403.1 39058.0 True False 36896.75696159533 48045.440614440304 44794.77462235877 46123.3726867623 42605.47863509301 34319.95493939367 24587.668704657437 22279.64197210878 14884.066571569418 37930.29405512871 0.972751672000454 1.2666772512918043 1.180976202221187 1.2160035622113974 1.1232572722259755 0.904816474386207 0.6482330105039836 0.5873838452116155 0.3924057786089555 1.0 15.211062935738191 -7.016276954033992 2.068720282769014 0.6147460261375058 1.1693301548523778 0.6828346648840058 0.15815368827225995 0.16900926453881882 1.4481596290746066 0.06693769240257066 0.0515562408106626 9.632145759361363e-08 7.016276954033992 0.554584128714872 ETNLDSLPLVDT(ph)HSK ddPTM_A459_Selumetinib_30min_R1 1 ETNLDSLPLVDTHSK 15 0 P08670 P08670 VIM Vimentin 1 ETNLDSLPLVDT(0.986)HS(0.014)K 90.729 0.020696 2359300.0 2379.7 3029.4 3239.9 3490.3 3097.3 2860.4 3549.9 3435.4 1713.4 2919.1 True False 2435.1423799098566 2674.71643967015 2799.9393754968037 2880.7846260454226 2817.14976187273 2831.626973035401 3282.128184959112 3344.282032248121 2907.5146582152806 3293.794919441865 0.7393120821020916 0.812047047581026 0.8500648777402494 0.8746095906097191 0.8552899712256818 0.8596852695113214 0.9964579657300794 1.015327946651521 0.8827248597213697 1.0 11.6855350164371 -2.223776799644658 0.20164876974033666 1.0138314478547557 0.0068236149959838505 0.7231352149411434 0.0446202976886603 21.899509023678178 0.3400649360904471 0.08749829765773887 6.588240326961775 0.00597342204453684 2.223776799644658 -1.0070078328587717 ETNLDSLPLVDT(ph)HSK ddPTM_A459_Selumetinib_30min_R2 1 ETNLDSLPLVDTHSK 15 0 P08670 P08670 VIM Vimentin 1 ET(0.025)NLDS(0.437)LPLVDT(0.531)HS(0.006)K 186.17 5.1805e-05 22373000.0 34570.0 25077.0 26398.0 29357.0 27686.0 24584.0 22474.0 27606.0 19445.0 23562.0 True False 32648.737794674696 27000.325264736122 24699.581419969243 25358.525956350288 24207.837164019642 27970.222848667465 23519.085531386172 27686.328889580665 23334.543338694933 22881.70383857195 1.4268490679281647 1.17999627367003 1.0794467752149155 1.1082446541241886 1.0579560567169046 1.2223837458082008 1.0278555171114392 1.2099767169833526 1.0197904624287475 1.0 14.481906862956686 -4.766831180022353 2.60640943240785 1.1003802444262387 1.5019334135262448 0.665541791339116 0.0715681726493687 0.2902094443827158 2.487572835806274 0.016959363823546732 0.26394249908125106 1.7106801654986634e-05 4.766831180022353 0.40155316910000605 ETNLDSLPLVDT(ph)HSKR ddPTM_A459_Selumetinib_30min_R2 1 ETNLDSLPLVDTHSKR 16 1 P08670 P08670 VIM Vimentin 1 ETNLDSLPLVDT(0.5)HS(0.5)KR 58.885 0.043687 4137000.0 35928.0 44267.0 42964.0 40443.0 42101.0 28015.0 22722.0 27003.0 23599.0 40561.0 True False 33931.265591179406 47662.13655916072 40199.743015666274 34934.59363193362 36811.89599228456 31873.811955150486 23778.61802278884 27081.57425941271 28319.459411152584 39389.898539865775 0.8614204872053227 1.2100091222860796 1.0205596994615478 0.8868921963984491 0.9345516834735671 0.8091874601528004 0.6036729949614607 0.6875258699131698 0.7189523319663033 1.0 15.265538080425726 -6.476111973344628 1.3007886752550646 0.7278921899834215 1.0357645160314957 0.4167275669732108 0.13013202412124888 0.3644476392802867 1.2741593693175466 0.054407633179271234 0.06362277745098138 3.3410888624272963e-07 6.476111973344628 0.30787232604807413 ETNLDSLPLVDTHS(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 ETNLDSLPLVDTHSKR 16 1 P08670 P08670 VIM Vimentin 1 ETNLDSLPLVDT(0.117)HS(0.883)KR 87.79299999999998 0.007418099999999999 4214100.0 20494.0 21442.0 27662.0 21857.0 24676.0 14786.0 12967.0 15459.0 15398.0 24031.0 True False 19355.025523982156 23086.532453103326 25882.25703610838 18880.038894571946 21575.980273761063 16822.637286055862 13569.991193623046 15503.983130624787 18478.030256067104 23337.16258996362 0.8293649859690303 0.9892604708951173 1.1090575787152164 0.8090117563260023 0.9245331428183146 0.7208518696823326 0.5814756246099496 0.6643473931699148 0.7917856416706702 1.0 14.510341543583994 -6.747205905439652 5.434992991211799 0.7191189771640932 0.9399865768698483 0.31351122634785344 0.12906737123459094 0.17927817326006612 15.758974570215255 0.04403998920624636 0.04198751120250189 1.789757102524977e-07 6.747205905439652 0.2208675997057551 ETNLDSLPLVDTHSK ddPTM_A459_Selumetinib_30min_R1 2 ETNLDSLPLVDTHSK 15 0 P08670 P08670 VIM Vimentin 0 ; 179.81 2.8176e-05 14218400.0 10721.0 12189.0 10209.2 11407.2 10833.599999999999 10452.3 11110.2 10516.5 5999.6 9750.9 False True 10970.778440565447 10761.906213487639 8822.846715121445 9415.146659664035 9853.702792827431 10347.159351929076 10272.14866912667 10237.568257593683 10180.88300655328 11002.522996809183 0.9971147930112992 0.9781307629721542 0.8018930492288122 0.8557261513922307 0.8955857484401607 0.9404351488226685 0.9336175595457217 0.9304746066481895 0.9253225836933779 1.0 13.425546766719117 -6.767102225291973 23.37117758198869 0.9408526350408419 0.9011723025694932 0.10985051352455488 0.05565996460552636 162.98632706584908 672653.459527071 0.021050446750625732 0.01911249447093849 1.7096128548921179e-07 6.767102225291973 -0.03968033247134872 ETNLDSLPLVDTHSK ddPTM_A459_Selumetinib_30min_R2 3 ETNLDSLPLVDTHSK 15 0 P08670 P08670 VIM Vimentin 0 ;; 167.29 0.00010376 61021600.0 369667.0 318919.0 383264.0 394035.0 403239.0 329269.0 319298.0 335994.0 290083.0 328871.0 False True 349122.3880342498 343379.06181378884 358605.2115062911 340366.75325171114 352580.51181760133 374622.8159436169 334145.9896769837 336971.68691319873 348107.7055962278 319375.639720524 1.093140316962672 1.0751573354632478 1.1228320726655787 1.0657254684469855 1.1039680801144818 1.1729849410914308 1.0462475784608518 1.055095145040093 1.0899632354579276 1.0 18.284894750258353 -8.936384067653957 0.6400761098172165 0.9992348203043669 1.099523118898921 0.41162398308466364 0.03400303514230229 1.5240657743063968 1.1482607253193402 0.04071541701260484 0.01416507535311655 1.1577530461810932e-09 8.936384067653957 0.10028829859455402 ETNLDSLPLVDTHSKR ddPTM_A459_Selumetinib_30min_R1 1 ETNLDSLPLVDTHSKR 16 1 P08670 P08670 VIM Vimentin 0 116.87 0.0012729000000000002 13004000.0 4223.1 3238.4 8954.7 9208.9 7457.0 4857.2 4690.3 4764.2 3360.9 3493.8 False True 4321.490013277858 2859.246622508686 7738.700924646194 7600.738487462309 6782.515666640277 4808.340977984741 4336.506894817809 4637.837939697411 5703.201829576124 3942.2632624939174 1.0961951867577808 0.7252804879144211 1.9630096747396342 1.928013930417727 1.7204623879810568 1.219690481792668 1.1000043898830056 1.1764404431893434 1.4466821340511435 1.0 11.944808406759483 -6.887840773432611 8.981052959427082 1.1905953063550259 1.4948907692561 0.14429244316299972 0.363216430006959 0.6296880759671971 47.290858130122885 0.1435363772473802 0.1266185295945378 1.2946704229854123e-07 6.887840773432611 0.3042954629010741 ETPAAQS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 ETPAAQSPTR 10 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 ETPAAQS(0.771)PT(0.228)R 126.5 0.0034461 6064500.0 2154.7 2467.3 1943.6 1801.9 2119.2 2156.8 2118.5 1894.9 1247.1 1918.6 True False 2204.900317683646 2178.42736898335 1679.6697954305957 1487.231990852147 1927.5187341751484 2135.104550217717 1958.6998393858646 1844.6410964973402 2116.2376154197937 2164.870998746588 1.0184903945594144 1.0062619759997757 0.7758752352463897 0.6869841167040535 0.8903619362498452 0.9862502437576627 0.9047651525286763 0.8520789911109466 0.9775352049360206 1.0 11.080065344249912 -6.53137552212654 24.46196213864197 0.9330747433643796 0.8638949064662175 0.10041667252413777 0.0999290442062255 421.53415929775423 1213571.6377647014 0.03649089646705994 0.03655058381890275 2.941876776276059e-07 6.53137552212654 -0.0691798368981621 ETPAAQS(ph)PTRGPSDTK ddPTM_A459_Selumetinib_30min_R1 2 ETPAAQSPTRGPSDTK 16 1 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 ETPAAQS(0.969)PT(0.031)RGPSDTK;ETPAAQS(0.855)PT(0.128)RGPS(0.017)DTK 247.02 1.4996e-28 6185800.0 2254.2 2257.3 2934.6 2683.0 2359.1 1892.88 2063.58 1912.2199999999998 1207.73 1768.0700000000002 True False 2306.7184740903485 1993.0142666096995 2536.097438603944 2214.4644161475735 2145.719821532934 1873.8393457975278 1907.9224992022098 1861.5017138340513 2049.429600890826 1995.0190069602202 1.1562388458669675 0.9989951271925097 1.2712146750261575 1.1099966508698675 1.0755385357467517 0.9392588939053107 0.9563430185606512 0.9330746761507765 1.0272732208268582 1.0 10.962186776030324 -6.576088271353347 3.1755496266150227 0.9661664517060026 1.1323654299617205 0.5664029015517187 0.06737658582888463 0.18417859067370085 3.799339737116598 0.023092720227870383 0.023748940352747723 2.6540660621123733e-07 6.576088271353347 0.16619897825571794 ETPAAQS(ph)PTRGPSDTK ddPTM_A459_Selumetinib_30min_R2 2 ETPAAQSPTRGPSDTK 16 1 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 ETPAAQS(0.891)PT(0.108)RGPS(0.001)DTK;ETPAAQS(0.499)PT(0.499)RGPS(0.001)DTK 196.65 4.7788e-06 13711000.0 49528.0 53777.0 54900.0 58259.0 55461.0 42969.0 43660.0 39964.0 31667.7 57827.0 True False 46775.43203629297 57901.52297969112 51367.79377060048 50324.02369761935 48493.493352369194 48887.589716254195 45690.27651064874 40080.28862360363 38002.12486946721 56157.384257410275 0.8329346648677052 1.0310580477588875 0.9147112966505775 0.8961247815059836 0.8635283497195689 0.87054606197765 0.8136111949448511 0.7137135953463647 0.6767075313778103 1.0 15.777188117778307 -6.876020303134246 1.2178174482293298 0.775664532633236 0.9273328079150419 0.21601434264204755 0.09334730475863365 0.5590526961318891 1.7311032165040134 0.048425589503581695 0.039200215183990805 1.3303922210946828e-07 6.876020303134246 0.15166827528180593 ETPAAQSPT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 ETPAAQSPTR 10 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 ETPAAQS(0.063)PT(0.937)R 111.17 0.02108 19714000.0 45140.0 44594.0 48111.0 55352.0 60549.0 47403.0 49438.0 44206.0 53573.0 46050.0 True False 42631.2995097372 48014.21640769002 45015.590639296126 47812.96211247408 52942.29330507208 53932.332968409726 51736.96495953855 44334.632141302754 64289.09695468778 44720.41684773101 0.9532849314641438 1.0736531497721522 1.0066004257645933 1.069152872060046 1.1838506220846694 1.2059890486272626 1.1568980927816093 0.9913734098735748 1.437578213404995 1.0 15.448646015435193 -6.081139663997539 3.4724477648434133 1.1637748453084433 1.0186087977139602 0.2499393856942146 0.11891893078150229 0.3533517719153783 8.141940610781589 0.03428674458384536 0.047111386593895827 8.295839401742295e-07 6.081139663997539 -0.14516604759448315 ETPAAQSPT(ph)RGPSDTK ddPTM_A459_Selumetinib_30min_R1 1 ETPAAQSPTRGPSDTK 16 1 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 ETPAAQS(0.41)PT(0.582)RGPS(0.007)DTK 228.32 3.9536e-14 7263500.0 1092.4 1199.4 1373.4 1220.5 1075.4 888.6 892.72 910.01 597.08 852.85 True False 1117.8507945596205 1058.9736904140677 1186.8998235461927 1007.3625866224791 978.130259877291 879.6614907842462 825.3814116670051 885.8735786709292 1013.2011510022061 962.3216049624873 1.1616187237147149 1.10043636654645 1.2333712736216287 1.046804500104461 1.016427621320442 0.9141034413526824 0.85769809948222 0.9205587551008603 1.052871665540235 1.0 9.910375308661795 -6.183149088391995 2.0151451809699994 0.9417404169528464 1.1572188662539593 0.6815691900458074 0.06197771260784675 0.1870343648515312 1.4931795559687628 0.021184455342605383 0.02918821248385387 6.559200576995518e-07 6.183149088391995 0.21547844930111293 ETPAATEAPS(ph)STPK ddPTM_A459_Selumetinib_30min_R2 1 ETPAATEAPSSTPK 14 0 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 ETPAAT(0.008)EAPS(0.847)S(0.142)T(0.003)PK 171.76 1.3468e-09 0.0 25705.0 20250.0 23607.0 20775.0 15604.0 11674.0 18996.0 17417.0 11876.0 16968.0 True False 24276.41900526795 21803.109885987407 22088.151321358197 17945.409161126037 13643.686018470082 13281.987533979174 19879.351639859895 17467.680586460432 14251.531843164892 16478.08975184148 1.4732544470183495 1.3231576119768884 1.3404558206687627 1.0890466936023686 0.8279895439303185 0.8060392760328831 1.2064111762492564 1.0600549486938171 0.864877668333627 1.0 14.008261385099688 -5.823758217377137 3.033887953227011 0.9673455929201089 1.3845839480285034 0.7201532287272459 0.11657984508573684 0.1451403880875746 2.7035943320091795 0.03668033280787282 0.061128911004155455 1.500519980088512e-06 5.823758217377137 0.41723835510839447 ETPAATEAPSS(ph)TPK ddPTM_A459_Selumetinib_30min_R1 1 ETPAATEAPSSTPK 14 0 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 ETPAATEAPS(0.002)S(0.879)T(0.119)PK 212.83 1.6641e-39 0.0 1482.1 1390.4 1763.6 1568.6 1342.2 1535.4 1578.0 1788.1 794.59 1339.6 True False 1516.6300463354198 1227.6113216205772 1524.1128067613686 1294.6734562687602 1220.7982469846563 1519.9552700316594 1458.9701895449111 1740.6737794326307 1348.3611954425576 1511.5507088089898 1.0033603487443912 0.8121535813957974 1.0083107353786873 0.8565200285532493 0.8076462402948897 1.0055602244593513 0.9652141876831185 1.1515814648416103 0.8920383468345461 1.0 10.561813663310222 -6.864351408920721 10.303504169467432 1.010553999154896 0.8967884139504593 0.26359218007499396 0.08754087411129284 0.43118627562379336 39.91852240003251 0.029545450978145992 0.026062386627380085 1.3666225768834756e-07 6.864351408920721 -0.11376558520443669 ETPAATEAPSST(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 ETPAATEAPSSTPK 14 0 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 ETPAATEAPS(0.001)S(0.013)T(0.986)PK;ETPAATEAPSS(0.054)T(0.946)PK;ETPAATEAPSS(0.067)T(0.933)PK 276.71 4.9842e-54 335128700.0 13645.699999999999 14289.099999999999 16955.7 16035.3 12234.0 13167.9 12671.2 13685.600000000002 7563.8 10609.8 True False 13963.618260089906 12616.125529177627 14653.209070993284 13235.035874860669 11127.436860088126 13035.442881496601 11715.401182358348 13322.61343090612 12835.216161905415 11971.671178203667 1.166388389075779 1.0538316114250859 1.223990272775933 1.1055295186320484 0.9294806626786907 1.0888574107539555 0.9785936322481109 1.112844918022979 1.0721323673902745 1.0 13.547336938031195 -6.011128608537654 24.908213506289066 1.0345924104304147 1.1429985236695603 0.41233084889788496 0.06396550521362933 527.7345088858104 1181187.167039534 0.017925127723645674 0.024670435114047477 9.747009547331568e-07 6.011128608537654 0.10840611323914562 ETPAATEAPSST(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 ETPAATEAPSSTPK 14 0 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 ETPAATEAPSS(0.021)T(0.979)PK;ETPAATEAPS(0.003)S(0.028)T(0.969)PK;ETPAATEAPS(0.003)S(0.019)T(0.978)PK;ETPAATEAPSS(0.108)T(0.892)PK 285.81 4.9117e-55 261254000.0 1590250.0 1046660.0 1176220.0 1129740.0 816850.0 755130.0 1499030.0 1040820.0 682107.0 925190.0 True False 1501870.2712751362 1126935.4564576575 1100543.2857715078 975867.4630897988 714230.0002683472 859142.3031123613 1568737.865271594 1043848.6138829725 818547.4596619785 898477.3607676934 1.6715727483571547 1.2542725122141762 1.2248981819988893 1.086134727152146 0.7949337751349481 0.9562203129729138 1.7459959858434322 1.1617973467813016 0.9110384917908008 1.0 19.777122626564164 -4.4850762286290635 1.4425490312323406 1.1165837164984105 2.300242741711619 0.32790268204205253 0.2434394124126412 3.346201240505134 3.691174157935141 0.0744352861521812 7.015707738049762 3.2728324413127617e-05 4.4850762286290635 1.1836590252132086 ETPAATEAPSSTPK ddPTM_A459_Selumetinib_30min_R2 1 ETPAATEAPSSTPK 14 0 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 0 139.76 0.0065269 0.0 11307.0 7027.5 11305.0 13323.0 13219.0 10602.0 11079.0 11115.0 11414.0 13095.0 False True 10678.60220550728 7566.486653026007 10577.648607953337 11508.384416543073 11558.311040640592 12062.329264626276 11594.19545262202 11147.34280981269 13697.118933806336 12716.91332510397 0.8397165202366413 0.5949939627322376 0.8317779902668997 0.9049668046274102 0.9088928063875198 0.9485264982355818 0.9117145927018598 0.8765761411463857 1.0770788935682514 1.0 13.634460918807092 -5.608913644700863 2.852264870925448 0.9405063365618416 0.7152447727579897 0.5809546426065918 0.07786903583697377 0.17049398746935537 2.7807688179949497 0.020880476232404264 0.041852739252031194 2.4608568733280823e-06 5.608913644700863 -0.22526156380385187 ETPDSYRDS(ph)PHSER ddPTM_A459_Selumetinib_30min_R1 1 ETPDSYRDSPHSER 14 1 Q02297-2;Q02297-6;Q02297;Q02297-7;H0YBA3;Q02297-11;A0A494C0Q4;Q02297-12;Q02297-3;A0A494C1F5;A0A494C1F8;A0A494C0K4;A0A494C0L9;A0A494C1B5;A0A494C1G2;F6RJN6;A0A494C043 Q02297-2 NRG1 Pro-neuregulin-1, membrane-bound isoform;Neuregulin-1 1 ETPDSY(0.003)RDS(0.986)PHS(0.011)ER 78.166 0.021261 4762900.0 1832.5 1312.0 1850.2 1343.5 1705.5 1559.9 1361.8 1353.2 525.16 1560.0 True False 1875.193684575709 1158.3904300677477 1598.953002421118 1108.8829456184358 1551.2378261304816 1544.2088222758791 1259.0783296085306 1317.3087401869225 891.158163831175 1760.2411956867904 1.0653049645529218 0.658086194611404 0.9083715381387022 0.6299607964724315 0.8812643573685013 0.8772711524191875 0.7152873894178338 0.7483683164641254 0.5062704849851405 1.0 10.78155741124048 -7.280131135137887 22.65687388714876 0.7215121938930917 0.8244754480351647 0.06664774938682416 0.1616216476134731 649.0301736883029 786702.6454152869 0.06359021627970825 0.04299645009089079 5.2464901865684856e-08 7.280131135137887 0.10296325414207297 ETPHS(ph)PGVEDAPIAK ddPTM_A459_Selumetinib_30min_R1 4 ETPHSPGVEDAPIAK 15 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 ET(0.081)PHS(0.919)PGVEDAPIAK;ET(0.001)PHS(0.999)PGVEDAPIAK;ET(0.003)PHS(0.997)PGVEDAPIAK;ETPHS(1)PGVEDAPIAK 192.23 1.9624e-05 255518000.0 31120.3 34407.3 35105.4 36480.8 35033.6 29864.499999999996 31714.9 29794.0 17512.3 24914.4 True False 31845.342440437347 30378.87732048019 30338.2795001591 30110.113109428377 31864.81706568443 29564.090244796454 29322.61955918754 29003.7663354487 29717.094052213964 28112.40592680704 1.132786091782728 1.0806217511078238 1.0791776263884103 1.0710614092519342 1.1334788331047545 1.0516385656129537 1.0430490949629636 1.0317070125894734 1.0570811381133605 1.0 14.778919307836897 -7.398668855164377 0.25065643968955154 0.9886996474053846 1.1287494143361048 0.6282653564466671 0.024180558398897087 1.6720125882440255 0.35048602562999587 0.058107263517384544 0.08741137809797182 3.9932927054958764e-08 7.398668855164377 0.14004976693072013 ETPHS(ph)PGVEDAPIAK ddPTM_A459_Selumetinib_30min_R2 4 ETPHSPGVEDAPIAK 15 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 ET(0.092)PHS(0.908)PGVEDAPIAK;ET(0.017)PHS(0.983)PGVEDAPIAK;ET(0.049)PHS(0.951)PGVEDAPIAK;ETPHS(1)PGVEDAPIAK 175.7 1.2644e-05 443609300.0 602440.0 538174.0 597192.0 601864.0 612102.0 442675.0 506559.0 496254.0 414174.0 552480.0 True False 568958.796558398 579450.2152978453 558769.3168934862 519889.0849266889 535204.2744986912 503649.46304644796 530114.9972276166 497698.0169807282 497020.37298846117 536528.46688457 1.0604447511650956 1.0799990141483204 1.041453252495736 0.9689869541228632 0.9975319252050727 0.938718994671357 0.9880463571780373 0.9276264871287886 0.9263634712142708 1.0 19.033295193309883 -5.711756183108757 1.6297390459116274 0.9580549165487604 1.0748610616865433 0.7437533377975496 0.026204045958324075 0.183911362846758 0.9843530637564919 0.0082305281621573 0.019067398346841645 1.9419758145842634e-06 5.711756183108757 0.11680614513778287 ETPPNGNLS(ph)PAPR ddPTM_A459_Selumetinib_30min_R1 1 ETPPNGNLSPAPR 13 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 ETPPNGNLS(1)PAPR 146.27 0.0006047 9956900.0 1364.3 1566.1 1374.7 1455.2 1363.6 1140.9 1648.4 1428.9 1022.1 1252.6 True False 1396.0855355343183 1382.7402839398617 1188.0232906865806 1201.0766374871216 1240.262620763133 1129.4235818543168 1524.0598608655457 1391.000930278668 1734.4290487696032 1413.3834113572264 0.9877613705637754 0.9783193101241092 0.840552734056614 0.8497882654033463 0.877513214600523 0.7990921449755576 1.0783060340308086 0.9841638999731395 1.2271468837348862 1.0 10.464937166208276 -7.278419663950654 24.761421880523844 1.0710845544760474 0.8884206669122287 0.5474412759098135 0.08176094494745617 588.4398395122321 858086.1662263718 0.03458119328318737 0.023384051040028588 5.267206389772185e-08 7.278419663950654 -0.1826638875638188 ETPPNGNLS(ph)PAPR ddPTM_A459_Selumetinib_30min_R2 2 ETPPNGNLSPAPR 13 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 ETPPNGNLS(1)PAPR;ET(0.002)PPNGNLS(0.998)PAPR 112.24 0.0049792000000000005 25914000.0 49899.0 47553.0 54814.0 59498.0 69397.0 61394.0 44288.0 43191.0 43948.0 59492.0 True False 47125.81334152365 51200.1621930054 51287.32691697072 51394.269760225136 60678.728442948435 69850.46622075699 46347.47975500716 43316.67865934502 52738.82800971792 57774.31138122074 0.8156880145323838 0.8862098217867772 0.8877185325248449 0.8895695774044413 1.0502717729089501 1.2090229126203234 0.8022160480492059 0.7497567279257075 0.9128421741234363 1.0 15.818140538693788 -6.0199045968887575 23.45492830637525 0.9487802744974513 0.8693622022080001 0.10541339002245687 0.12105160982913349 1035.1106797904092 1219743.4353545152 0.0401201921525583 0.05261861369532258 9.552023958983927e-07 6.0199045968887575 -0.07941807228945119 ETPS(ph)QENGPTAK ddPTM_A459_Selumetinib_30min_R1 3 ETPSQENGPTAK 12 0 O15355 O15355 PPM1G Protein phosphatase 1G 1 ETPS(0.943)QENGPT(0.057)AK;ET(0.01)PS(0.989)QENGPT(0.001)AK;ET(0.001)PS(0.981)QENGPT(0.018)AK 181.75 0.00010413 15756900.0 6806.7 7227.799999999999 7372.0 8253.2 7011.299999999999 6483.000000000001 6916.9 6189.700000000001 3573.7 5323.8 True False 6965.282866467382 6381.565815886941 6370.922891497403 6811.933551751456 6377.129152945552 6417.786906093035 6395.152664171862 6025.5290490208345 6064.307887279062 6007.161588203419 1.1594965049958827 1.0623263120503965 1.060554606023637 1.1339687557478744 1.0615877497733135 1.0683559634380375 1.0645880871142805 1.003057593931464 1.0095130284472227 1.0 12.55246775647791 -7.486670646370514 0.8669606876226765 0.9946191427912753 1.0977185629664363 0.623951410145478 0.030542468615497344 0.4157052151012347 0.5825467967633257 0.025635593673314343 0.012848498842073668 3.260838977935946e-08 7.486670646370514 0.10309942017516105 ETPS(ph)QENGPTAK ddPTM_A459_Selumetinib_30min_R2 1 ETPSQENGPTAK 12 0 O15355 O15355 PPM1G Protein phosphatase 1G 1 ETPS(0.9)QENGPT(0.099)AK 115.83 0.0051613 9267600.0 53531.0 53624.0 58527.0 67703.0 65112.0 46153.0 48336.0 59473.0 49498.0 52424.0 True False 50555.96132157162 57736.788371663686 54761.43653937946 58481.734605810656 56932.04845133449 52510.15681477992 50583.719775966936 59646.05658371481 59398.983089674584 50910.38290609016 0.9930383241239354 1.1340867044383771 1.0756437766416527 1.1487192055437236 1.118279714304093 1.0314233328718174 0.9935835656407104 1.171589235416645 1.1667361292340421 1.0 15.635672295959274 -10.828617428056209 5.283055567541132 0.9999799519506783 1.093312514691216 0.15817089115168115 0.06404475066742142 1.5531680163422e-05 2.040995090618558e-06 0.06367913488935914 0.015441141761945049 1.4838246173119528e-11 10.828617428056209 0.09333256274053758 ETPSSSPAS(ph)PQETR ddPTM_A459_Selumetinib_30min_R1 1 ETPSSSPASPQETR 14 0 Q9BX66-4;Q9BX66-9;Q9BX66-8;Q9BX66-10;Q9BX66-6;Q9BX66-5;Q9BX66-12;Q9BX66-7;Q9BX66-3;Q9BX66-2;Q9BX66-11;Q9BX66;S4R406 Q9BX66-4 SORBS1 Sorbin and SH3 domain-containing protein 1 1 ETPS(0.001)S(0.016)S(0.226)PAS(0.726)PQET(0.031)R 108.36 0.0049121 1962200.0 642.7 727.45 924.76 1073.4 870.31 603.54 722.86 670.74 483.04 492.47 True False 657.6736595234971 642.2798158176702 799.1826713430735 885.9508402134943 791.5906141657103 597.468935570475 668.3340882220751 652.9497963294245 819.6836001542594 555.6833215640216 1.1835403979237928 1.155837850252397 1.4381980533331478 1.5943448468453298 1.4245354925134446 1.0751968115379889 1.2027247575849274 1.1750393992240715 1.4750912405417977 1.0 9.118119129256986 -6.747648209791245 24.998977952851256 1.1976200310176257 1.3654306015858764 0.21640614156004911 0.16424700726085004 424.4912608803976 769465.7821559786 0.0581041047044655 0.057815931578311885 1.7879352640817436e-07 6.747648209791245 0.16781057056825066 ETPSSSPAS(ph)PQETR ddPTM_A459_Selumetinib_30min_R2 1 ETPSSSPASPQETR 14 0 Q9BX66-4;Q9BX66-9;Q9BX66-8;Q9BX66-10;Q9BX66-6;Q9BX66-5;Q9BX66-12;Q9BX66-7;Q9BX66-3;Q9BX66-2;Q9BX66-11;Q9BX66;S4R406 Q9BX66-4 SORBS1 Sorbin and SH3 domain-containing protein 1 1 ETPSSS(0.001)PAS(0.996)PQET(0.003)R 127.3 0.0016227 0.0 7587.8 6989.9 6818.2 7971.7 11120.0 4435.8 4301.6 6946.2 7766.5 7141.6 True False 7166.10045237005 7526.002853929056 6379.524435094865 6885.940708050467 9723.006185938686 5046.791185816761 4501.6329234586965 6966.412291994682 9320.017014141129 6935.403451894807 1.0332636741431696 1.0851571802751998 0.9198490728541435 0.9928680798186547 1.4019380780626804 0.7276853063880425 0.6490801803648228 1.004471093904624 1.3438319888361832 1.0 12.759764095274061 ETQPWS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 3 ETQPWSSPK 9 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 ETQPWS(0.963)S(0.037)PK;ETQPWS(0.711)S(0.289)PK;ETQPWS(0.5)S(0.5)PK 110.39 0.010881 20189500.0 277053.0 203215.0 231070.0 246090.0 213803.0 206696.0 245448.0 232122.0 159810.0 210262.0 True False 261655.50339103266 218800.93706078661 216203.2077699934 212572.11747107145 186943.15571692892 235166.49780052743 256861.8183459853 232797.43659013428 191776.4654644812 204191.18973371605 1.2814240601284284 1.0715493520857733 1.0588273081318647 1.0410445120001746 0.9155299793331919 1.1516975737650876 1.2579476062652681 1.140095402224373 0.9392004900631375 1.0 17.63956109382743 -1.5228787577333527 0.010905583972092469 1.4070267211939643e-08 2.3322071841368675 0.10355479785161725 0.11040470419645727 37420.870603053525 31.65207532451404 2877.9776133276782 3972.456183093835 0.029999999139776204 1.5228787577333527 2.3322071700666003 ETQPWSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ETQPWSSPK 9 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 ETQPWS(0.354)S(0.646)PK 107.06 0.009554 0.0 62908.0 51621.0 51487.0 44577.0 47762.0 39153.0 55610.0 52098.0 36738.0 36911.0 True False 59411.825200676736 55580.164712323785 48174.38247480699 38505.53570038584 41761.71056230244 44545.97035445322 58195.97518912451 52249.59655471181 44086.62654548597 35845.28352370465 1.6574516745386438 1.5505572630097448 1.3439531714946276 1.074214845446039 1.1650545471257112 1.242728916483385 1.6235322884428922 1.4576421614899184 1.2299142930849265 1.0 15.129495683006569 -5.220120196392906 3.0706292071050085 1.281829403478703 1.6331896273624538 0.39166610646842537 0.1704313630244336 0.30246443531621503 5.655327718603054 0.049208295600630544 0.15497557524987965 6.023928432987245e-06 5.220120196392906 0.35136022388375077 ETQS(ph)PEQVK ddPTM_A459_Selumetinib_30min_R1 4 ETQSPEQVK 9 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 ETQS(1)PEQVK;ET(0.004)QS(0.996)PEQVK;ETQS(1)PEQVK;ETQS(1)PEQVK 184.44 0.00045359 1514730000.0 40012.2 44310.0 35070.4 34312.3 36164.0 32988.5 39887.1 36717.09999999999 21541.6 34629.700000000004 True False 40944.4064098118 39122.164600839846 30308.032307917834 28320.300926641958 32892.97258527277 32656.665641161504 36878.383933711564 35743.24323405061 36554.52186378559 39074.75931684288 1.0478479490509114 1.0012131945231595 0.7756422006892256 0.7247722422805738 0.8417959102078079 0.835748350395727 0.9437904309193126 0.9147399461688752 0.9355021631068381 1.0 15.25394936644127 -7.275324789328019 22.652583238015865 0.9414031595308837 0.8647492340333253 0.14026245017917494 0.09232232712362053 557.566544093462 909602.3740722836 0.04324380630786028 0.02937980775747577 5.3048756803184344e-08 7.275324789328019 -0.07665392549755845 ETQS(ph)PEQVK ddPTM_A459_Selumetinib_30min_R2 8 ETQSPEQVK 9 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 ET(0.025)QS(0.975)PEQVK;ET(0.005)QS(0.995)PEQVK;ET(0.003)QS(0.997)PEQVK;ETQS(1)PEQVK;ET(0.184)QS(0.816)PEQVK;ET(0.054)QS(0.946)PEQVK;ET(0.027)QS(0.973)PEQVK;ET(0.009)QS(0.991)PEQVK 161.93 0.00093257 2150548000.0 12193867.0 10249469.0 11146933.0 11767038.0 11452659.0 8271175.0 10573344.0 10869152.0 9259227.0 10164652.0 True False 11516180.688057177 11035570.315062782 10429751.46664301 10164347.125127256 10013873.588349495 9410454.277998982 11065025.446683671 10900779.432835016 11111331.124418326 9871172.085822405 1.1666477484064366 1.1179594701740392 1.0565869357725888 1.0297001244387105 1.0144563888955038 0.9533269399198161 1.1209434250038 1.104304467398699 1.1256344259641784 1.0 23.234789967279255 -5.05830193379657 2.379348206736922 1.0508641162895542 1.1678772850080619 0.3485771495581378 0.05224356678337529 0.43992882866424426 4.326029163149905 0.015383921098798303 0.08274825318148978 8.743756731900387e-06 5.05830193379657 0.11701316871850764 ETQS(ph)PEQVKSEK ddPTM_A459_Selumetinib_30min_R1 1 ETQSPEQVKSEK 12 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 ET(0.008)QS(0.909)PEQVKS(0.083)EK 187.74 0.00056408 11814000.0 1705.5 1487.2 4042.3 4244.1 2421.3 2136.0 2184.0 1932.7 1507.6 1373.9 True False 1745.2348316746916 1313.077932619478 3493.3778627645056 3502.947606623897 2202.2938425152347 2114.5137793328277 2019.2591216515123 1881.438517705635 2558.2870892525716 1550.253447919283 1.125773875244147 0.8470085548797605 2.253423701429752 2.2595967203462624 1.4206024476004917 1.3639794074774565 1.3025348367144216 1.2136328548282616 1.6502379612096654 1.0 10.59828838284876 -6.507464041276752 24.07899375798745 1.3273279128587312 1.6398774564316474 0.10392125560481014 0.43355894696011593 1165.8631564433063 1821174.3191656515 0.15024203388446009 0.16494019185587802 3.1083932608926905e-07 6.507464041276752 0.3125495435729162 ETQS(ph)PEQVKSEK ddPTM_A459_Selumetinib_30min_R2 3 ETQSPEQVKSEK 12 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 ETQS(1)PEQVKSEK;ET(0.085)QS(0.915)PEQVKSEK;ET(0.058)QS(0.942)PEQVKSEK 114.7 0.025804 204627400.0 112912.0 172257.0 153066.0 153980.0 136199.0 68260.0 52510.0 60965.0 37366.8 153518.0 True False 106636.80306254876 185468.55800644655 143217.9002056598 133007.65836968398 119088.46398549137 77662.19539741456 54951.81904659104 61142.398056700964 44841.204115625915 149085.53645233414 0.7152726253672692 1.2440412559118024 0.9606424849364891 0.8921566875953081 0.7987928729999004 0.5209237411319564 0.36859255669083846 0.41011622932483127 0.3007750126717531 1.0 17.185780775648773 -6.586669347288617 1.8948787253981132 0.4638659203250551 0.9828027925181222 0.46363678971746514 0.21746279546124964 0.2578937280495624 1.8860968399559828 0.07941406293915917 0.08241200792031883 2.59018421693216e-07 6.586669347288617 0.5189368721930672 ETQST(ph)PQSAPQVR ddPTM_A459_Selumetinib_30min_R1 1 ETQSTPQSAPQVR 13 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 ETQS(0.008)T(0.944)PQS(0.049)APQVR 190.24 0.00037942 2621000.0 1253.5 1241.9 1465.6 1475.3 1438.1 1123.2 1274.5 960.09 802.39 1071.6 True False 1282.7041111135884 1096.4977706563536 1266.5795699645403 1217.6665498108514 1308.024108917177 1111.9016277840037 1178.3634388941628 934.6252943881641 1361.5972257530987 1209.1502982679267 1.060830992599535 0.9068333128040867 1.047495560956218 1.0070431703611404 1.081771315601447 0.919572719269698 0.9745384346198606 0.7729603968398207 1.1260777321922244 1.0 10.239777868445886 -6.784664120095852 24.995550660053823 0.9454341617011387 1.0151830971644016 0.0909960568218331 0.09286569390338532 513.4656164282516 552611.399414816 0.031097417293345194 0.027441547889035856 1.64185908307821e-07 6.784664120095852 0.06974893546326288 ETQST(ph)PQSAPQVR ddPTM_A459_Selumetinib_30min_R2 2 ETQSTPQSAPQVR 13 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 ETQS(0.096)T(0.904)PQSAPQVR;ETQS(0.086)T(0.91)PQS(0.005)APQVR 184.0 2.0924e-14 2359000.0 17239.2 18954.3 19890.5 19842.7 22418.4 21662.2 18503.1 18688.699999999997 18508.9 18168.5 True False 16281.114277985425 20408.03386231956 18610.76688513896 17140.090029433246 19602.000168961124 24645.971420127084 19363.530813197085 18743.08102291916 22211.197181875606 17643.928197567886 0.9227601753803149 1.156660446234002 1.0547972467777527 0.9714441045954783 1.110977099286946 1.3968528518226677 1.0974614380864596 1.062296378280591 1.2588578310433893 1.0 14.106884174018566 -6.52009018600173 24.949930660375873 1.172999611250836 1.038179035981345 0.22773426717282996 0.11724379218691165 167.5777340354494 1499380.2029440764 0.037910536242253386 0.038595712221908995 3.019324659489681e-07 6.52009018600173 -0.1348205752694911 ETQSTPQS(ph)APQVR ddPTM_A459_Selumetinib_30min_R2 2 ETQSTPQSAPQVR 13 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 ETQS(0.001)T(0.027)PQS(0.972)APQVR;ETQS(0.042)T(0.376)PQS(0.582)APQVR 151.22 0.00047135 19761500.0 44347.0 34481.0 43620.0 45804.0 42517.0 39862.0 34211.0 36326.0 30132.0 35058.0 True False 41882.37127510671 37125.58182611022 40813.53668986503 39565.416183692796 37175.6343531974 45352.628668792015 35801.879287810465 36431.70264590696 36159.241958424056 34045.78444837684 1.230177889970853 1.0904604616293458 1.1987838538938658 1.1621237937309183 1.0919306150682562 1.33210702598319 1.0515803899920815 1.0700796952159481 1.0620769221297228 1.0 15.055188554235327 -7.4214656371854035 24.908081267249557 1.0517128272567526 1.176823199881996 0.5000859265376779 0.06741115098683075 33.05714682304875 8110.971820884684 0.026991793941698386 0.018197861239064878 3.7890851305610097e-08 7.4214656371854035 0.12511037262524338 ETQTHENMSQLS(ph)EEEQNKDYQDCSK ddPTM_A459_Selumetinib_30min_R2 2 ETQTHENMSQLSEEEQNKDYQDCSK 25 1 A0A087X0M4;Q9BWU0 A0A087X0M4 SLC4A1AP Kanadaptin 1 ETQTHENMS(0.012)QLS(0.879)EEEQNKDY(0.106)QDCS(0.004)K;ETQTHENMS(0.004)QLS(0.533)EEEQNKDY(0.432)QDCS(0.031)K 75.225 0.00013296 52356000.0 122917.0 113087.0 112408.0 121523.0 115403.0 81424.0 99566.0 107297.0 84473.0 113894.0 True False 116085.76521573716 121760.40926798343 105175.79166057661 104971.35776113237 100905.04342409015 92639.41690652048 104196.01628628626 107609.21650602548 101369.96037282504 110605.58428784941 1.0495470546371841 1.1008522766002822 0.9509085127823036 0.9490601983345248 0.9122961021704497 0.8375654584078481 0.9420502315246367 0.972909434897736 0.9164994789866233 1.0 16.755064701067354 -5.345521413550812 4.5057257142392535 0.9289419118078721 1.0751081326292462 0.6368176424360981 0.042274230922242605 0.12758925287135242 4.5958739557548025 0.011609262954505322 0.02585948315533169 4.513137720795121e-06 5.345521413550812 0.1461662208213741 ETQTHENMSQLSEEEQNKDYQDCS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 ETQTHENMSQLSEEEQNKDYQDCSK 25 1 A0A087X0M4;Q9BWU0 A0A087X0M4 SLC4A1AP Kanadaptin 1 ETQTHENMS(0.001)QLS(0.012)EEEQNKDY(0.202)QDCS(0.785)K 71.001 0.00043389 16408000.0 1627.4 2196.9 1847.0 2164.6 1549.3 1850.3 1812.7 1921.4 999.66 1969.7 True False 1665.3152536308369 1939.6859266888982 1596.187544844778 1786.593244574371 1409.1660885511317 1831.6876619379814 1675.966579586858 1870.4382304132098 1696.3500077223566 2222.5301815027383 0.7492880265431775 0.8727377215536402 0.7181848679173094 0.8038555604074571 0.6340368739552235 0.8241452364437665 0.7540804590800528 0.8415805760390325 0.7632517307708231 1.0 11.117987295352082 -10.074226603424302 0.5683319977616682 1.0346562065536256 0.7677165177831626 0.528950918980434 0.06428644323242692 8.81961111218402 2.2566259251500416 0.6698305409638786 0.026548213055564963 8.428948426733962e-11 10.074226603424302 -0.2669396887704629 ETS(ph)FS(ph)RSISLTR ddPTM_A459_Selumetinib_30min_R1 1 ETSFSRSISLTR 12 1 A0A087WZ32;A0A087X038;A8K727;Q9HB19 A0A087WZ32 PLEKHA2 Pleckstrin homology domain-containing family A member 2 2 ETS(0.987)FS(0.645)RS(0.368)ISLTR 129.34 0.020202 0.0 1997.0 2556.2 1766.4 2032.0 2316.7 1895.4 2336.1 2082.5 937.99 1802.6 True False 2043.5262145144275 2256.91891565486 1526.5325821406682 1677.1493453640949 2107.1548940466046 1876.3339968855062 2159.8860961950986 2027.2653350866594 1591.7005219209473 2033.9812688109018 1.004692740218353 1.109606538792902 0.7505145723554788 0.8245647937282055 1.035975564946319 0.9224932528422158 1.0619006818375485 0.9966981339370108 0.7825541691696507 1.0 10.990090677958753 -6.291639562831398 24.964422052781266 0.9689978548172041 0.9234468379392157 0.0339372684781688 0.11519934118291912 3122.8569480212886 2581443.9058384937 0.03776050727289202 0.042823100503196834 5.109288629574127e-07 6.291639562831398 -0.04555101687798846 ETS(ph)HGSPTVTK ddPTM_A459_Selumetinib_30min_R1 2 ETSHGSPTVTK 11 0 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 ET(0.01)S(0.769)HGS(0.221)PTVTK;ET(0.028)S(0.617)HGS(0.355)PTVTK 187.78 1.9372e-05 8184500.0 2561.9 3727.3 3551.8 3762.8 3561.3999999999996 3589.8 3332.5 3608.7 2043.76 2695.9 True False 2621.5872854103727 3290.905983225241 3069.4850686408654 3105.6976165039464 3239.271998816237 3553.689871277612 3081.1268419888593 3512.985553290386 3468.111449675534 3041.945025289756 0.8618128413286027 1.0818426881043883 1.0090534323014224 1.0209578380556426 1.0648686849650366 1.168229485323822 1.0128805143989645 1.1548484683597338 1.140096688415723 1.0 11.570778365252929 -3.6488398460500076 0.7700589452731953 1.0895029407910481 4.5778275284402536e-38 0.4690618785263184 0.06357067220833025 11.768408458984977 1.411796519514422 0.02334648324754891 16.50469842730964 0.00022447095484429767 3.6488398460500076 -1.0895029407910481 ETS(ph)RSRGGGGAVS(ph)ER ddPTM_A459_Selumetinib_30min_R1 2 ETSRSRGGGGAVSER 15 2 Q8N7J2-2;Q8N7J2 Q8N7J2-2 AMER2 APC membrane recruitment protein 2 2 ETS(1)RSRGGGGAVS(1)ER;ETS(1)RSRGGGGAVS(1)ER 115.18 0.022914 489693800.0 5264.7 6371.5 5096.200000000001 4055.1 1998.77 5804.6 4414.5 2995.6 2249.7 2651.7 True False 5387.3572666770715 5625.521817970009 4404.164031422824 3346.952908654501 1817.9816064115041 5746.210994155119 4081.5107108656603 2916.1469569198557 3817.576588413048 2992.071524745295 1.8005442791464283 1.8801428279522465 1.4719447697018995 1.1186072528595103 0.6075996483961936 1.9204791552047789 1.3641086709025465 0.9746247483733189 1.2758975033987616 1.0 11.546928947575465 -5.468189037261434 3.23786912773033 1.1958907080844556 1.8370610181763434 0.40678905595115167 0.31732091270581847 0.25889567143965253 5.341525663235943 0.09035282714427711 0.20138035291116832 3.4026005098004846e-06 5.468189037261434 0.6411703100918877 ETS(ph)RSRGGGGAVS(ph)ER ddPTM_A459_Selumetinib_30min_R2 2 ETSRSRGGGGAVSER 15 2 Q8N7J2-2;Q8N7J2 Q8N7J2-2 AMER2 APC membrane recruitment protein 2 2 ETS(1)RSRGGGGAVS(1)ER;ETS(1)RSRGGGGAVS(1)ER 122.69 0.014572 87284000.0 124781.0 167094.0 179516.0 80911.0 107235.0 273190.0 124102.0 114431.0 104638.0 164051.0 True False 117846.17155792021 179909.57250810732 167966.13600224254 69890.7822207397 93763.1806069365 310819.44272809406 129872.9889034479 114763.97526492813 125568.52383000072 159314.421374313 0.7397081227256749 1.1292736147558513 1.0543059099941876 0.43869714755156813 0.5885417013607179 1.950981210908813 0.8151992003178936 0.7203614981928563 0.7881805221824488 1.0 17.281517342075283 ETSELGGSDVS(ph)ILDTTR ddPTM_A459_Selumetinib_30min_R1 2 ETSELGGSDVSILDTTR 17 0 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 ETSELGGS(0.022)DVS(0.974)ILDT(0.002)T(0.002)R;ETSELGGS(0.023)DVS(0.754)ILDT(0.112)T(0.112)R 100.11 0.0069637 3748400.0 5370.5 6157.0 6828.6 7565.5 5428.4 6562.4 5516.6 5389.9 3526.5 5283.8 True False 5495.62220082611 5436.135577688356 5901.31362681486 6244.327447023652 4937.402178461863 6496.388214182462 5100.478420559861 5246.942343137377 5984.212934630668 5962.027198570426 0.9217707363267061 0.911793153005379 0.989816622814112 1.047349708253749 0.8281415052326082 1.089627403199396 0.8554939873107008 0.8800601151895933 1.0037211732387874 1.0 12.54158724153313 -5.914651727089865 0.0030455449971509047 1.8933860521286454 9.895390044121891e-08 0.01641709018745685 0.08105522029923999 456027.54611364525 332.4212941433253 101862.29181420499 104806.25753408883 1.2171616854292712e-06 5.914651727089865 -1.893385953174745 ETSFGS(ph)SENITMTSLSK ddPTM_A459_Selumetinib_30min_R1 3 ETSFGSSENITMTSLSK 17 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2;A0A087WZS7 Q9UMZ2-6 SYNRG Synergin gamma 1 ETSFGS(0.912)S(0.087)ENIT(0.001)MTSLSK;ET(0.015)S(0.195)FGS(0.736)S(0.054)ENITMTSLSK;ETS(0.002)FGS(0.678)S(0.201)ENIT(0.109)MT(0.009)S(0.001)LSK 349.47 2.8895999999999984e-175 89038700.0 13375.4 16012.2 17171.2 18327.2 17494.6 13750.6 15936.4 15596.6 8868.0 13044.7 True False 13687.020796002149 14137.484180130172 14839.445354650039 15126.698564151995 15912.216518922496 13612.28144854587 14734.304517530756 15182.927503103285 15048.348306906206 14719.114311138133 0.9298807324055506 0.9604847058924031 1.0081751551736269 1.0276908137540204 1.0810580163020764 0.9248030255628418 1.0010320054638837 1.0315109443517385 1.0223677857789946 1.0 13.845403242699014 -5.112417085988919 2.573319501324138 1.0131274481774517 0.9315034648950916 0.3620848337974194 0.036613219291555886 0.3513358864362337 4.214995195683047 0.010177722668620694 0.044416678467750416 7.719388774372326e-06 5.112417085988919 -0.08162398328236009 ETSFGS(ph)SENITMTSLSK ddPTM_A459_Selumetinib_30min_R2 7 ETSFGSSENITMTSLSK 17 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2;A0A087WZS7 Q9UMZ2-6 SYNRG Synergin gamma 1 ETS(0.001)FGS(0.961)S(0.038)ENITMTSLSK;ETSFGS(0.763)S(0.237)ENITMTSLSK;ET(0.027)S(0.019)FGS(0.893)S(0.06)ENIT(0.002)MTSLSK;ETS(0.001)FGS(0.499)S(0.499)ENIT(0.002)MTSLSK;ETSFGS(0.958)S(0.036)ENIT(0.007)MTSLSK;ETS(0.005)FGS(0.821)S(0.17)ENIT(0.003)MT(0.001)SLSK;ET(0.001)S(0.108)FGS(0.667)S(0.193)ENIT(0.03)MTSLSK 145.82 0.00045755 75722200.0 212627.0 182445.0 224128.0 237562.0 249716.0 180663.0 200508.0 204091.0 159685.0 189321.0 True False 200810.04255332044 196437.9448468628 209707.84849211542 205205.64578269227 218344.4435906355 205547.6883545727 209832.01929906476 204684.87102091612 191626.4619716891 183854.81081496857 1.092220767371791 1.0684406025391302 1.1406165961203232 1.1161287804930553 1.1875916796671548 1.117989175499116 1.1412919703811266 1.1132962478034416 1.0422705890711879 1.0 17.488207401579558 -8.379133964616413 2.524539793258652 1.0012498867182074 1.124414162898473 0.660863152182178 0.029772722432081955 0.17000743407994995 2.1050592089494846 0.030159829899174997 0.00832321135805399 4.177015005087121e-09 8.379133964616413 0.1231642761802656 ETSFGSS(ph)ENITMTSLSK ddPTM_A459_Selumetinib_30min_R1 1 ETSFGSSENITMTSLSK 17 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2;A0A087WZS7 Q9UMZ2-6 SYNRG Synergin gamma 1 ETSFGS(0.019)S(0.973)ENIT(0.008)MTS(0.001)LSK 157.83 0.0014325999999999998 0.0 2228.2 3237.4 3730.8 3812.3 3408.6 2732.6 3372.0 3079.3 1521.1 2545.3 True False 2280.1127246775404 2858.3637029735705 3224.177851817484 3146.553370734026 3100.2927318372076 2705.112525002286 3117.647325187226 2997.6269610239383 2581.1956032515823 2872.0140483215323 0.7939072324559443 0.9952471174867897 1.1226191089496111 1.0955912184945407 1.0794838324865041 0.9418869404845749 1.0855264886358225 1.0437368726576448 0.8987405910357887 1.0 11.487847090715196 -4.784305900752541 3.9278480810712706 1.0386177935375056 0.7719167972972724 0.531281048678756 0.0669133015888715 0.18053096627327062 5.13565883908417 0.017108315025015804 0.13695455683542537 1.6432138972285754e-05 4.784305900752541 -0.26670099624023325 ETSFGSS(ph)ENITMTSLSK ddPTM_A459_Selumetinib_30min_R2 1 ETSFGSSENITMTSLSK 17 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2;A0A087WZS7 Q9UMZ2-6 SYNRG Synergin gamma 1 ET(0.001)S(0.085)FGS(0.276)S(0.631)ENIT(0.008)MTSLSK 168.16 4.5931e-06 6261500.0 49823.0 30866.0 46015.0 46292.0 50770.0 34072.0 35226.0 46248.0 30489.0 35156.0 True False 47054.037117271546 33233.3229501673 43054.444997343904 39986.94974184584 44391.8187104413 38765.10872517889 36864.078798994786 46382.57402323145 36587.6519338375 34140.954933742294 1.3782285003038082 0.9734151553365614 1.2610791080946655 1.171231145099747 1.3002512318882986 1.1354430126635515 1.0797612096831295 1.358561121481417 1.071664574258205 1.0 15.059215791134408 -8.512692027273763 24.05719944568813 0.9999999701886852 1.1976661962642812 0.256219594529013 0.11907789939677514 434.14261886957905 1025280.5916337508 0.10684322426002137 0.02758680185800455 3.0711991062567627e-09 8.512692027273763 0.19766622607559592 ETSFGSSENIT(ph)MTSLSK ddPTM_A459_Selumetinib_30min_R2 1 ETSFGSSENITMTSLSK 17 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2;A0A087WZS7 Q9UMZ2-6 SYNRG Synergin gamma 1 ETSFGS(0.01)S(0.001)ENIT(0.989)MTSLSK 144.33 0.005033 5786900.0 47158.0 42951.0 51808.0 49641.0 55836.0 35711.0 41504.0 44132.0 32775.0 42753.0 True False 44537.14714843127 46245.203590767655 48474.72968428543 42879.81016449858 48821.38249982668 40629.86609781827 43434.01823861579 44260.416813554104 39330.91581001422 41518.60980436578 1.0727032373744867 1.113842775773886 1.167542215712343 1.0327853067948742 1.175891551520422 0.9785940880310001 1.046133732397962 1.0660380254085486 0.9473081106361728 1.0 15.341470517322197 -6.772178306518297 24.996281854641946 1.014149597530493 1.1112480914529284 0.5256366725854964 0.04964298235747441 182.8999327165545 425721.3909416424 0.016765211157974077 0.01493379377306869 1.689747036642909e-07 6.772178306518297 0.0970984939224353 ETSHGS(ph)PTVTK ddPTM_A459_Selumetinib_30min_R1 2 ETSHGSPTVTK 11 0 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 ET(0.024)S(0.001)HGS(0.938)PT(0.037)VTK;ET(0.06)S(0.033)HGS(0.907)PTVTK 182.23 3.7626e-05 8443100.0 3743.9 4979.9 4652.6 4384.5 4833.0 4751.200000000001 4491.6 4359.2 2696.1000000000004 3644.2 True False 3831.1255856387415 4396.850992907299 4020.80247490244 3618.8293822583064 4395.856003335452 4703.407241744442 4152.794995792093 4243.579855322815 4575.084784647024 4111.968567513977 0.9317010873833045 1.0692812750671283 0.9778290881570005 0.8800722385984059 1.0690393010453163 1.1438334618856385 1.009928681994473 1.0320068808036653 1.112626400112061 1.0 12.005613521065223 -6.333295457576756 24.99768368964158 1.0644038089903973 0.9731250465201448 0.3764630241012694 0.060385312891242236 172.5432533451448 60024.471033419984 0.019019426072553986 0.02156600559400738 4.641993654218274e-07 6.333295457576756 -0.09127876247025257 ETSHGS(ph)PTVTK ddPTM_A459_Selumetinib_30min_R2 2 ETSHGSPTVTK 11 0 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 ETSHGS(0.997)PT(0.003)VTK;ET(0.004)S(0.114)HGS(0.865)PT(0.016)VT(0.002)K 178.15 6.071600000000001e-05 4050600.0 20020.8 17046.8 17388.3 21793.6 21217.6 16781.9 21628.1 25945.3 21959.4 28190.5 True False 18908.124085612468 18354.23474589877 16269.555708949578 18825.27408394303 18552.055400249337 19093.4543940796 22633.84950526712 26020.79652752436 26351.893596900893 27376.567017284724 0.6906681934836628 0.6704359510931547 0.5942876511389277 0.6876418826384378 0.677661862735972 0.697437862900216 0.8267599619403266 0.9504769721892312 0.9625711500007695 1.0 14.740653925573328 -7.506529543194299 1.4541603886192809 0.9885077127910342 0.6589473420919949 0.9643802196787733 0.02622610539626267 0.07220097784582688 0.29267633137169485 0.018695326279839428 0.008949576283346678 3.115088982598917e-08 7.506529543194299 -0.3295603706990393 ETSQVILRPSS(ph)SPNPTTIQNENLK ddPTM_A459_Selumetinib_30min_R2 1 ETSQVILRPSSSPNPTTIQNENLK 24 1 Q9ULH0-2;Q9ULH0-4;Q9ULH0;Q9ULH0-5 Q9ULH0-2;Q9ULH0-5 KIDINS220 Kinase D-interacting substrate of 220 kDa 1 ETSQVILRPS(0.1)S(0.45)S(0.45)PNPTTIQNENLK 108.96 2.4475e-07 7382100.0 34977.0 17194.0 25003.0 26790.0 20269.0 19043.0 39295.0 25715.0 19123.0 16524.0 True False 33033.1183640248 18512.724512576173 23394.33420120807 23141.15578467228 17722.62701284092 21666.000394857412 41122.29536156531 25789.82639265258 22948.13434126322 16046.909185492008 2.0585346363080315 1.1536629452177312 1.457871664305227 1.4420942698170294 1.1044262049456806 1.350166573787656 2.562630278904048 1.607152261818066 1.4300656952686317 1.0 13.970007824425252 ETSTNGPVSQEAFSVTGPAAPGALPPPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ETSTNGPVSQEAFSVTGPAAPGALPPPSPK 30 0 Q86UK7-2;Q86UK7-3 Q86UK7-2 1 ETSTNGPVSQEAFSVTGPAAPGALPPPS(1)PK 142.47 6.2269e-18 0.0 7477.5 9049.0 7676.9 5934.4 7356.3 6255.8 5802.8 6269.6 6598.0 8932.0 True False 7061.930484804162 9743.029202879019 7182.976611976729 5126.124482588995 6432.135827843591 7117.479665501712 6072.641698030059 6287.84349801185 7917.784363523236 8674.109951876944 0.8141389173048318 1.123231000867216 0.8280937931185024 0.5909683542205711 0.7415326602416166 0.820542938121461 0.7000881625573622 0.7248978319269814 0.9128065481588631 1.0 13.082500015391606 -5.5086892238386085 24.689105029355066 0.7645628173102261 0.9704293600815208 0.23311989279636935 0.12833994175860777 627.2444682589511 1091373.7935509102 0.032207486559397785 0.0630867149393421 3.0996365702539886e-06 5.5086892238386085 0.20586654277129468 ETSVSKEDTDHEEKAS(ph)NEDVTK ddPTM_A459_Selumetinib_30min_R1 1 ETSVSKEDTDHEEKASNEDVTK 22 2 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 ETSVSKEDT(0.006)DHEEKAS(0.977)NEDVT(0.016)K 45.43600000000001 0.033726 8037600.0 1593.5 2479.3 2121.7 2228.5 1992.4 2082.4 1933.8 1796.1 1187.0 1692.2 True False 1630.6254495887538 2189.0224034047 1833.584793663867 1839.334309125928 1812.1877717867912 2061.452946667922 1787.9319090886884 1748.4615934449696 2014.2523049501194 1909.4103534238384 0.8539942431257982 1.1464389514173725 0.9602884944956931 0.9632996416028361 0.9490824057475579 1.0796280343674947 0.9363790794800487 0.9157076111532205 1.0549080250551093 1.0 10.89891147186164 ETSVSKEDTDHEEKAS(ph)NEDVTK ddPTM_A459_Selumetinib_30min_R2 1 ETSVSKEDTDHEEKASNEDVTK 22 2 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 ET(0.006)S(0.006)VS(0.013)KEDT(0.417)DHEEKAS(0.556)NEDVT(0.002)K 46.962 0.029655 10513000.0 40344.0 42666.0 32453.0 28073.0 29344.0 22197.0 23968.0 24765.0 10502.0 31611.0 True False 38101.841989828055 45938.34500718709 30365.009312154754 24249.40897137384 25657.544381311567 25254.43526569607 25082.559491690987 24837.062049933535 12602.693450397242 30698.308294758437 1.241170738920937 1.4964454902888185 0.9891427573336153 0.7899265568166273 0.8357966873924596 0.8226653737140337 0.8170665057778995 0.8090694057618257 0.41053380953077084 1.0 14.905871534102252 -5.464629560951166 3.342383034292183 0.7828331972205063 1.3664575932138017 0.6992592585314488 0.151436091890627 0.12511130927634673 2.742800119932415 0.04036792183437606 0.0895272875974101 3.4306028103141426e-06 5.464629560951166 0.5836243959932954 ETTDTDTADQVIASFK ddPTM_A459_Selumetinib_30min_R1 2 ETTDTDTADQVIASFK 16 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ; 351.52 4.060399999999997e-173 17904300.0 4268.4 4636.1 4936.4 4976.299999999999 4794.9 4728.6 4263.8 4498.4 2678.2 3452.4 False True 4367.845415139402 4093.303256735582 4266.063993704255 4107.282621720153 4361.202141608352 4681.034577225286 3942.178133194926 4379.087819137494 4544.709792011298 3895.5491692237683 1.1212399652523815 1.0507641102502676 1.0951123470363784 1.0543526582000695 1.1195346155718964 1.2016366303901727 1.0119698050122286 1.1241259265147656 1.1666416195991391 1.0 11.92761100906395 -4.417089330347776 20.744807321899064 1.0956220258339373 5.134442394003549 0.016886187035091482 0.06125690392205129 1864.5521234852658 372127.69835904456 0.0143652490362583 6350.827434758121 3.8274600791485124e-05 4.417089330347776 4.0388203681696115 ETTDTDTADQVIASFK ddPTM_A459_Selumetinib_30min_R2 1 ETTDTDTADQVIASFK 16 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 134.04 0.0067145 3069100.0 13669.0 13691.0 16893.0 15427.0 17262.0 11864.0 12427.0 11903.0 11470.0 12228.0 False True 12909.331701342446 14741.05567649648 15806.122771707707 13325.815986940624 15093.393235762009 13498.158309330902 13004.88012363334 11937.635759352279 13764.320498577068 11874.945867840497 1.0871065725279012 1.241357715694345 1.3310479851965935 1.1221790932983826 1.2710283822545794 1.1366921971313029 1.0951527921363338 1.0052791728239838 1.1591059573461584 1.0 13.535633316456103 -7.102293175997267 2.580594845009514 1.0629037828717014 1.213974858155069 0.4355367020355243 0.077699095296816 0.27201703916372516 3.5380170337004975 0.03258772249493014 0.024356533909466335 7.9014505048485e-08 7.102293175997267 0.1510710752833675 ETTGSES(ph)DGGDSSSTK ddPTM_A459_Selumetinib_30min_R2 1 ETTGSESDGGDSSSTK 16 0 Q5JPT2;Q96B97-2;Q96B97;Q5JPT1;Q5VSN0;Q5JPT3 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 ETTGS(0.004)ES(0.996)DGGDSSSTK 288.42 1.6302999999999999e-74 8465300.0 15756.0 9088.4 14657.0 16870.0 14048.0 13502.0 29691.0 65342.0 17873.0 32856.0 True False 14880.344596265382 9785.451056188045 13713.98457733499 14572.276897626785 12283.164649286566 15361.777941047347 31071.690331600366 65532.13440204961 21448.09941334505 31907.361909859956 0.4663608554760237 0.30668317499367326 0.42980628157469575 0.456705789052516 0.3849633411871272 0.4814493277270998 0.9738094430802394 2.0538249005725224 0.6721990828930673 1.0 14.96160171154819 -7.366887437011539 3.664286423602962 1.3060957203403938 0.4137883547605793 0.5569676927361873 0.33160192080849044 0.15760818225108122 3.866585500352393 0.13935775044807786 0.0901955272075257 4.2964777096153605e-08 7.366887437011539 -0.8923073655798145 ETTSGTSTEPVKNS(ph)SPAPPQPAPGK ddPTM_A459_Selumetinib_30min_R1 3 ETTSGTSTEPVKNSSPAPPQPAPGK 25 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 ETTSGTSTEPVKNS(0.785)S(0.215)PAPPQPAPGK;ETTSGTSTEPVKNS(0.5)S(0.5)PAPPQPAPGK;ETTSGTSTEPVKNS(0.5)S(0.5)PAPPQPAPGK 110.67 1.0167e-07 42566100.0 7425.68 7844.4 10676.9 10487.3 10214.6 8906.61 9196.609999999999 9088.6 5063.320000000001 7349.21 True False 7598.683896141965 6925.974001237373 9227.035624013646 8655.889926002394 9290.691233534099 8817.017589954847 8502.902303466812 8847.540804066555 8592.084229738872 8292.552690867507 0.9163262724287912 0.8352040993197267 1.112689417599393 1.04381488411102 1.120365655772779 1.0632452899171718 1.0253660869506394 1.0669260882490683 1.036120546957903 1.0 13.01760055858666 -5.259472441821318 24.99998446118597 1.061617927054291 0.8757651746475568 0.7754709373336137 0.039317757528157374 68.37062450256111 868980.6433721546 0.009673622012852564 0.023112591952053427 5.502088329328059e-06 5.259472441821318 -0.18585275240673416 ETTSGTSTEPVKNS(ph)SPAPPQPAPGK ddPTM_A459_Selumetinib_30min_R2 1 ETTSGTSTEPVKNSSPAPPQPAPGK 25 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 ETTSGT(0.001)S(0.003)T(0.002)EPVKNS(0.497)S(0.497)PAPPQPAPGK 85.51799999999999 5.3379e-05 30651000.0 108110.0 122640.0 123590.0 144530.0 125410.0 91714.0 81105.0 74004.0 55732.0 134090.0 True False 102101.67899861957 132046.093650247 115638.35395461787 124844.76467184353 109654.87462037492 104346.77100320088 84876.54320650865 74219.3393879783 66879.95728218812 130218.47329233968 0.784079834582317 1.0140350313722717 0.8880334028721906 0.9587331314472394 0.8420838599005872 0.8013207985394132 0.6518010928907247 0.5699601409191485 0.5135980755360494 1.0 16.990574603714002 -6.976873591008418 1.9323091837381023 0.6468994538229418 0.9126034048698212 0.34676387561409305 0.13467035218412113 0.31218259813823857 2.353500278846979 0.057112257793959224 0.04484181062486757 1.0546938387749699e-07 6.976873591008418 0.2657039510468794 ETTSGTSTEPVKNSS(ph)PAPPQPAPGK ddPTM_A459_Selumetinib_30min_R1 1 ETTSGTSTEPVKNSSPAPPQPAPGK 25 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 ETTSGTSTEPVKNS(0.014)S(0.986)PAPPQPAPGK 130.89 3.2338e-08 28269000.0 2018.5 2663.0 2663.7 2624.1 2631.2 2131.1 2397.2 2221.0 1192.7 1713.2 True False 2065.527122682711 2351.2147220048864 2301.984170656759 2165.8501954576395 2393.2084245760893 2109.6630688839828 2216.3772740032077 2162.0918651752563 2023.9247886385908 1933.1059079811607 1.0685017898682252 1.2162886225206242 1.1908215484483395 1.1203991392895516 1.238012058571295 1.0913334133292312 1.1465369097743234 1.118454946647614 1.0469808096299684 1.0 10.91670496449455 -8.277226571236884 0.9564677587191285 0.9976627661025694 1.1628317896297493 0.524157185115893 0.04973698877756448 0.39564513562334935 0.7596398378240686 0.04489398034107402 0.01580815808796245 5.281696340248615e-09 8.277226571236884 0.16516902352717988 ETTSGTSTEPVKNSS(ph)PAPPQPAPGK ddPTM_A459_Selumetinib_30min_R2 1 ETTSGTSTEPVKNSSPAPPQPAPGK 25 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 ETTSGTSTEPVKNS(0.188)S(0.812)PAPPQPAPGK 146.97 5.1462e-10 33927000.0 63541.0 65622.0 62216.0 65692.0 60578.0 39222.0 41513.0 41630.0 28045.0 61992.0 True False 60009.64559477656 70654.9963920132 58213.090295658956 56744.636274979144 52967.65006580875 44624.474478133576 43443.43675644896 41751.13640778252 33654.7836427719 60202.12988544061 0.9968026996548073 1.1736295132159522 0.9669606441903862 0.942568583253769 0.8798301682449036 0.7412441148353065 0.7216262421133275 0.6935159351875304 0.5590297836108791 1.0 15.877526908408289 -6.255324029987087 1.0655791122581317 0.7134853523647251 1.0780820306271723 0.5718235714149023 0.11452364110507776 0.3327827821067305 0.7896827640149917 0.0482151945706486 0.07386135111609218 5.55489648115658e-07 6.255324029987087 0.36459667826244724 ETTSHNSLT(ph)TPCYTPYYVAPEVLGPEK ddPTM_A459_Selumetinib_30min_R2 1 ETTSHNSLTTPCYTPYYVAPEVLGPEK 27 0 P49137-2;P49137 P49137-2 MAPKAPK2 MAP kinase-activated protein kinase 2 1 ET(0.003)T(0.003)S(0.003)HNS(0.007)LT(0.274)T(0.218)PCY(0.194)T(0.218)PY(0.06)Y(0.019)VAPEVLGPEK 52.97 0.021286000000000003 1872800.0 3366.3 4135.0 6622.0 11826.0 13488.0 3312.9 4585.7 5377.2 5290.8 5868.4 True False 3179.2145223666007 4452.141203879406 6195.947729488457 10215.278399012112 11793.51685575009 3769.221903488062 4798.944136392165 5392.8467617566175 6349.107837303531 5698.964044065687 0.5578583226327084 0.7812193882001075 1.0872059696429 1.7924798823128651 2.0694141539690256 0.6613872055242989 0.8420730678919252 0.9462854511904092 1.1140810484521018 1.0 12.476483975111066 ETVDQVEELRR ddPTM_A459_Selumetinib_30min_R1 1 ETVDQVEELRR 11 1 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7;A0A2R8Y5T0 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 109.39 0.012751 6401300.0 2173.0 2694.6 2742.2 2788.8 2835.7 2426.7 2577.9 2346.3 1391.1 2167.3 False True 2223.626672078043 2379.1149793144455 2369.824301826394 2301.7884322595432 2579.211435683497 2402.2896012673095 2383.446927520803 2284.068502143496 2360.5950980759158 2445.494066289733 0.9092750224708974 0.9728565741007923 0.969057473699724 0.9412365640092443 1.0546790815144516 0.9823330321598479 0.9746279741078796 0.9339906130334026 0.9652835108520118 1.0 11.255910248808343 -3.7132343759062216 1.387934691496045 0.9777303058844332 1.5591071185830363e-14 0.29220148348816954 0.03157514027349163 30.199772606028173 4.884672637023522 0.009418495635265391 79.91732571165295 0.0001935377216134548 3.7132343759062216 -0.9777303058844177 ETVDQVEELRR ddPTM_A459_Selumetinib_30min_R2 1 ETVDQVEELRR 11 1 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7;A0A2R8Y5T0 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 99.5 0.023265 3089800.0 22899.0 16430.0 25465.0 23947.0 26170.0 17950.0 17728.0 20768.0 13409.0 24540.0 False True 21626.36525195997 17690.128169223375 23826.609624195633 20685.377289120832 22882.290637231596 20422.44956612355 18552.38712736558 20828.43144167252 16091.174678763718 23831.46643742278 0.9074710240239301 0.7423012853898239 0.999796201663045 0.8679859186776012 0.9601713221180261 0.8569531220308785 0.7784828170805548 0.8739886610152297 0.675207072171421 1.0 14.5405801081194 -6.999998603467654 24.99999999998025 0.8208900129094414 0.8930192581470557 0.0809123748007089 0.09868327501790068 0.14657508010234568 2065704.875520835 0.03325581481577237 0.029037967890473974 1.0000032156397314e-07 6.999998603467654 0.07212924523761433 ETVFTKS(ph)PYQEFTDHLVK ddPTM_A459_Selumetinib_30min_R1 2 ETVFTKSPYQEFTDHLVK 18 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 ET(0.001)VFT(0.052)KS(0.934)PY(0.013)QEFTDHLVK;ET(0.045)VFT(0.138)KS(0.816)PYQEFTDHLVK 104.16 0.00080577 75144000.0 8436.8 10419.099999999999 15020.300000000001 17885.7 11516.5 10550.9 10037.8 8530.1 4977.0 6171.5 True False 8633.361024844937 9199.226928291826 12980.625760602055 14762.298251170565 10474.834608403222 10444.76752545071 9280.640664520854 8303.854038330232 8445.605494302235 6963.672140500663 1.2397713233271532 1.3210310225246238 1.8640489527223485 2.1199013901463215 1.5042113409506552 1.4998936358166584 1.3327222300637505 1.1924533307699943 1.2128091793958333 1.0 12.765632565134098 -7.4175842095101805 1.3490067461747386 1.1186740317500592 1.6321948005353835 0.432550321679509 0.24067219524390152 0.4884549409918153 1.7036055764689686 0.18391106183520967 0.09364061115819429 3.823101167062888e-08 7.4175842095101805 0.5135207687853243 ETVNS(ph)PAIYK ddPTM_A459_Selumetinib_30min_R2 3 ETVNSPAIYK 10 0 Q9Y3A2 Q9Y3A2 UTP11L Probable U3 small nucleolar RNA-associated protein 11 1 ET(0.032)VNS(0.968)PAIYK;ET(0.294)VNS(0.706)PAIYK;ET(0.099)VNS(0.901)PAIYK 168.61 0.00026044 50503100.0 247770.0 252896.0 264278.0 262639.0 249431.0 190885.0 202960.0 191166.0 159852.0 285286.0 True False 233999.93530189586 272292.3100111934 247274.6412041298 226867.1151224539 218095.24783856777 217177.6760684954 212398.04215761018 191722.26141076506 191826.8666380591 277049.05191795394 0.8446155425617311 0.9828306869349287 0.8925301837068129 0.8188698483243283 0.7872080641631471 0.7838961171858151 0.7666441761385645 0.6920155838235541 0.69239315316216 1.0 18.079781904479198 -5.8845523255112555 2.0636716484815576 0.7697921642794001 0.9194009358751385 0.26438861459223995 0.08674795518439746 0.35468731996621516 3.0752407671897046 0.026072722945539483 0.04536890224295092 1.3045107865689191e-06 5.8845523255112555 0.14960877159573838 ETVQTTQS(ph)PTPVEK ddPTM_A459_Selumetinib_30min_R1 3 ETVQTTQSPTPVEK 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 ETVQT(0.026)T(0.002)QS(0.807)PT(0.165)PVEK;ETVQTTQS(0.919)PT(0.081)PVEK;ETVQTTQS(0.938)PT(0.062)PVEK 321.82 1.561199999999999e-109 76327000.0 18779.4 23503.5 10958.1 11582.199999999999 13985.3 14331.3 19382.4 18573.0 9182.5 17242.1 True False 19216.923481648613 20751.69929351928 9470.050208534678 9559.58619482088 12720.332084305255 14187.14013377927 17920.369963140234 18080.383706393524 15582.031836735025 19455.291487276412 0.9877479087998404 1.0666352291401393 0.48675961574402554 0.49136175631564116 0.6538237729629618 0.7292175572418195 0.9211051900641014 0.9293298801623164 0.8009148486377362 1.0 14.247874975079847 -7.257313235611596 21.53842860851763 0.906948329287183 0.7247825811959274 0.18696218942715115 0.17966972467247727 101.71802224227248 530975.6368147264 0.07925527620237574 0.05890677599709495 5.529511484293748e-08 7.257313235611596 -0.18216574809125563 ETVQTTQS(ph)PTPVEK ddPTM_A459_Selumetinib_30min_R2 3 ETVQTTQSPTPVEK 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 ETVQT(0.01)T(0.001)QS(0.56)PT(0.429)PVEK;ETVQTT(0.003)QS(0.982)PT(0.015)PVEK;ETVQTT(0.002)QS(0.99)PT(0.008)PVEK 270.07 2.5338e-44 201548600.0 585199.0 433566.0 527012.0 578826.0 570622.0 469198.0 559085.0 576216.0 521075.0 414700.0 True False 552675.9823172067 466819.1180655819 493104.6216872798 499988.90026945487 498935.3629345951 533825.7655446259 585083.5603059102 577892.6931623056 625304.5600519666 402726.5334800009 1.3723356579996786 1.1591466646901818 1.2244155293824637 1.241509706224221 1.2388936944959745 1.3255291647455736 1.4528060896562829 1.4349506305648057 1.5526778299126365 1.0 18.619441001249818 -6.944706504406177 3.579792357792472 1.3963370834912454 1.2410367935538291 0.09941179040196213 0.14516771392789343 0.37597988207820116 9.90423331351487 0.051672702972483595 0.043918640852695826 1.1357781136091435e-07 6.944706504406177 -0.1553002899374163 ETVQTTQSPT(ph)PVEK ddPTM_A459_Selumetinib_30min_R1 1 ETVQTTQSPTPVEK 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 ETVQTTQS(0.072)PT(0.928)PVEK 290.39 2.984699999999999e-66 12766000.0 4379.8 5311.8 2764.6 2773.6 3573.8 3301.2 4506.4 4418.9 2219.4 3709.4 True False 4481.840818392734 4689.8919866111755 2389.1825048607866 2289.242826920205 3250.5504210056365 3267.9929252497786 4166.478619876547 4301.696417389884 3766.1597014374893 4185.537622615756 1.0707921472682411 1.120499302471978 0.5708185471685391 0.5469411658255602 0.7766147898042789 0.7807821168759304 0.9954464624481626 1.02775241922244 0.8998030936546269 1.0 12.031197230177453 -7.2628970962849975 24.42343544895649 0.9830632043891817 0.8006462706073898 0.18430846449864768 0.17401537083073457 183.07546002523753 3067299.314637952 0.07899331268799005 0.05651978012260191 5.458871907690079e-08 7.2628970962849975 -0.1824169337817919 ETVS(ph)PPCFDEYK ddPTM_A459_Selumetinib_30min_R1 1 ETVSPPCFDEYK 12 0 Q13029-5;Q13029-3;Q13029-2;Q13029 Q13029-5 PRDM2 PR domain zinc finger protein 2 1 ET(0.015)VS(0.985)PPCFDEYK 107.53 0.0095671 0.0 1530.0 1895.5 1684.5 1954.6 1229.8 1327.7 1476.4 1552.0 1233.6 1299.2 True False 1565.646023138246 1673.5739788059568 1455.7541522961708 1613.2658023861516 1118.564807138825 1314.3445434551475 1365.0339593435403 1510.8359183935142 2093.3291014207816 1465.9649752796665 1.0679968822853785 1.1416193476837222 0.9930347428788004 1.1004804545745603 0.7630228729887855 0.8965729506630307 0.931150458818519 1.0306084687359516 1.4279530116477925 1.0 10.517634919788684 -10.06267557609239 6.418717697309273 0.9999959425262532 1.0268767201497173 8.004152945539911e-05 0.16675043842086706 0.0 0.0 0.16688452578332344 0.04047544276975039 8.656143030197043e-11 10.06267557609239 0.02688077762346408 ETVSEAPPLLFS(ph)DEEEKEAQLGVK ddPTM_A459_Selumetinib_30min_R2 2 ETVSEAPPLLFSDEEEKEAQLGVK 24 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 ET(0.001)VS(0.03)EAPPLLFS(0.969)DEEEKEAQLGVK;ETVS(0.002)EAPPLLFS(0.998)DEEEKEAQLGVK 65.954 0.0014792 6887300.0 19418.1 16001.3 18497.7 17170.699999999997 17511.2 15568.5 18423.8 17358.2 13344.699999999999 20258.0 True False 18338.919738813205 17228.548257711132 17307.57812077297 14832.021038890345 15311.286503885736 17712.919558228103 19280.543206067112 17408.709488195305 16014.012882071604 19673.098903394897 0.9321825620288292 0.8757414549844041 0.8797586087358246 0.7539239807476823 0.7782854434409181 0.9003624515490778 0.9800460670047237 0.8848992003588801 0.81400561043833 1.0 14.263936608158462 -6.974841430299039 24.429393631810353 0.9144400365064349 0.8423873659944521 0.22503577668657904 0.06715020685734095 297.9591684426315 289322.0286503899 0.025118040987112514 0.022151196668431232 1.0596405507552909e-07 6.974841430299039 -0.07205267051198283 ETVSEES(ph)NVLCLSK ddPTM_A459_Selumetinib_30min_R2 1 ETVSEESNVLCLSK 14 0 P13639 P13639 EEF2 Elongation factor 2 1 ETVS(0.001)EES(0.999)NVLCLSK 127.78 0.0015798 0.0 9936.7 6070.4 9657.6 8478.5 9371.7 7970.8 7284.4 7780.9 6620.9 9146.2 True False 9384.457993761758 6535.980160587554 9036.240530399835 7323.713673771708 8194.343261938988 9068.705348281756 7623.13903376477 7803.541130802664 7945.265003402691 8882.12544131851 1.0565554445005314 0.735857673230217 1.0173511498007448 0.824545174705902 0.9225655859148253 1.021006222913189 0.8582561779979939 0.8785668680720934 0.8945229445243292 1.0 13.11668923114052 -6.478477309659903 24.980735413479195 0.9243030077787568 0.9002030109346744 0.00636074271230469 0.09660519910846498 2951.2554658994154 1660407.0987839343 0.028464008610291188 0.032272919376269756 3.3229414594333394e-07 6.478477309659903 -0.024099996844082483 ETVSEESNVLCLSK ddPTM_A459_Selumetinib_30min_R1 1 ETVSEESNVLCLSK 14 0 P13639 P13639 EEF2 Elongation factor 2 0 289.86 1.909699999999999e-65 4931600.0 1236.4 1363.1 1733.3 1496.5 1519.6 1471.3 1204.9 1180.7 975.71 1223.3 False True 1265.2057143843965 1203.5076183120013 1497.927380335383 1235.1643677841384 1382.1524483071698 1456.500057833515 1114.0134229294454 1149.384000545892 1655.708606961148 1380.322470951059 0.9166015485589063 0.8719032281512957 1.0852010395102045 0.8948375425150438 1.0013257607512902 1.0551882538215644 0.8070675123921417 0.8326923778571484 1.1995085509405239 1.0 10.430789633473136 -1.5286501810480568 0.02426745064915008 1.2847964070399776 0.5232549943894377 0.04148728668879054 0.11521088878612287 10333.743643652024 19.3795293483551 211.66164000686268 432.73124139747483 0.02960396069666071 1.5286501810480568 -0.7615414126505399 ETVSEESNVLCLSK ddPTM_A459_Selumetinib_30min_R2 3 ETVSEESNVLCLSK 14 0 P13639 P13639 EEF2 Elongation factor 2 0 ;; 192.14 0.0010796 12133500.0 54254.0 54064.0 67554.0 68620.0 78119.0 49715.0 49395.0 59317.0 51803.0 63297.0 False True 51238.77987596995 58210.53495684068 63207.64918723388 59273.837623897445 68304.9928272792 56562.78998216331 51691.96537433564 59489.60264954199 62165.04749675569 61469.45114464348 0.8335649484717249 0.946983157859434 1.0282774290354448 0.9642812245780502 1.1112022566551154 0.9201772413595442 0.8409374805169403 0.9677913425574157 1.0113161308448224 1.0 15.907581982979353 -4.794298003889906 3.734685696715969 0.976898233562782 0.8205605927946028 0.3025543746907794 0.06665020085333165 0.3413001968843159 8.335520240398376 0.01794861964813154 0.14452385398718195 1.6058389813866053e-05 4.794298003889906 -0.15633764076817924 ETYEVEASTFCFPES(ph)VDVGGASPHSK ddPTM_A459_Selumetinib_30min_R1 1 ETYEVEASTFCFPESVDVGGASPHSK 26 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 ETYEVEAS(0.002)T(0.002)FCFPES(0.489)VDVGGAS(0.489)PHS(0.019)K 72.532 0.00031124 6047900.0 768.98 1190.7 1067.1 728.9 1196.8 1025.3 1246.1 1162.4 636.22 1022.9 True False 786.8957378253909 1051.2922904585873 922.1936811607262 601.6112981475829 1088.5496513122011 1014.9864128979153 1152.1056737591339 1131.5693759926694 1079.6188723297105 1154.1991788897549 0.6817677158480742 0.9108413085771249 0.798990068635988 0.5212369833136459 0.9431211451383086 0.8793858386506991 0.9981861838329891 0.9803935028624319 0.9353835040570861 1.0 10.172676494434786 -6.473019051294969 24.899565833825367 0.9545075706699508 0.7445434844927107 0.5653347483930131 0.0975102332194615 291.5017729396018 145573.7550139047 0.0309333882530776 0.03507463284565162 3.3649680786959583e-07 6.473019051294969 -0.20996408617724016 ETYEVEASTFCFPESVDVGGAS(ph)PHSK ddPTM_A459_Selumetinib_30min_R1 1 ETYEVEASTFCFPESVDVGGASPHSK 26 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 ETYEVEASTFCFPES(0.241)VDVGGAS(0.753)PHS(0.006)K 98.349 1.8777e-06 8602200.0 2548.9 3176.4 2747.6 2508.7 2495.1 2589.4 2897.1 2599.3 1690.5 2779.9 True False 2608.284410703969 2804.5056113317014 2374.491011486469 2070.6026391313517 2269.418645545683 2563.352986987089 2678.569414531409 2530.358120283676 2868.6550307651046 3136.727243519043 0.831530511966918 0.8940865410361191 0.7569963299781738 0.660115616813522 0.7234988793605335 0.8172062114368941 0.8539376256146409 0.8066873284923902 0.9145376081685723 1.0 11.615044368663275 -8.419229027433694 0.9231447153940431 1.0004315867615545 0.7793681794976962 0.5524044389603036 0.062329912835838566 0.4922512185094672 0.9254839744482596 0.06756819942992383 0.023609307749625007 3.808649193460709e-09 8.419229027433694 -0.2210634072638583 ETYEVEASTFCFPESVDVGGAS(ph)PHSK ddPTM_A459_Selumetinib_30min_R2 1 ETYEVEASTFCFPESVDVGGASPHSK 26 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 ETYEVEASTFCFPES(0.191)VDVGGAS(0.791)PHS(0.018)K 77.876 0.00011163 2896200.0 8423.7 7061.1 6173.3 7864.1 9126.0 5960.0 6499.9 7575.3 6193.5 7288.6 True False 7955.5444767428735 7602.663664984979 5776.116598980836 6792.996013670827 7979.510292524862 6780.935900506757 6802.158229307508 7597.342868841573 7432.373060848912 7078.159179942937 1.1239567060438742 1.0741018210678712 0.8160478525756187 0.9597122416969422 1.1273425886120283 0.9580083928772882 0.9610066765074285 1.0733501007394441 1.050043220546621 1.0 12.789158491400082 -7.770434006984757 24.98030520154072 1.0462724857663308 0.9998362190736065 0.03586399791008976 0.08872041052942786 735.2903742174876 2042050.9480381075 0.05022573705802826 0.024689468509806283 1.6965473807394745e-08 7.770434006984757 -0.04643626669272427 ETYVEQEQGENANDRNDR ddPTM_A459_Selumetinib_30min_R1 1 ETYVEQEQGENANDRNDR 18 1 F2Z2C0;Q9Y2L1 F2Z2C0 DIS3 Exosome complex exonuclease RRP44 0 117.13 0.0028906 7948600.0 778.91 723.56 900.57 1015.1 1198.1 649.61 789.49 680.55 371.39 587.41 False True 797.0570875049742 638.845258826082 778.2775404769149 837.8318407869554 1089.732066541735 643.0755131986878 729.9381336779547 662.4996032620533 630.2217047476205 662.8097953579347 1.2025427099708785 0.963844021769607 1.1742094729553967 1.2640607405847164 1.6441097795684374 0.97022632692296 1.1012784343112627 0.9995320043577299 0.9508334203288052 1.0 9.372451113411175 EVAATEEDVTRLPS(ph)PTSPFSSLSQDQAATSK ddPTM_A459_Selumetinib_30min_R1 3 EVAATEEDVTRLPSPTSPFSSLSQDQAATSK 31 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 EVAATEEDVT(0.002)RLPS(0.819)PT(0.07)S(0.103)PFS(0.003)S(0.002)LS(0.001)QDQAATSK;EVAATEEDVTRLPS(0.913)PT(0.064)S(0.022)PFS(0.001)SLSQDQAATSK;EVAATEEDVT(0.008)RLPS(0.91)PT(0.022)S(0.029)PFS(0.011)S(0.014)LS(0.005)QDQAATSK 128.18 2.4838e-18 388233000.0 7361.9 8221.3 9215.7 9878.5 9700.7 7598.799999999999 8761.6 8306.3 4505.87 6206.1 True False 7533.417946236243 7258.7463740213225 7964.258558216574 8153.405417411033 8823.273397797693 7522.362971158372 8100.705457995368 8085.989941335083 7646.132294275987 7002.713387533203 1.0757855604440192 1.0365619685283607 1.137310370633645 1.1643208805213112 1.2599792265531813 1.0742068902249078 1.1567952320334713 1.1546938299274703 1.0918813709965984 1.0 12.773698325610269 EVAATEEDVTRLPS(ph)PTSPFSSLSQDQAATSK ddPTM_A459_Selumetinib_30min_R2 3 EVAATEEDVTRLPSPTSPFSSLSQDQAATSK 31 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 EVAAT(0.003)EEDVT(0.03)RLPS(0.369)PT(0.103)S(0.128)PFS(0.147)S(0.177)LS(0.042)QDQAATSK;EVAAT(0.001)EEDVT(0.005)RLPS(0.265)PT(0.265)S(0.265)PFS(0.061)S(0.061)LS(0.073)QDQAAT(0.002)S(0.001)K;EVAATEEDVTRLPS(0.718)PT(0.062)S(0.091)PFS(0.033)S(0.048)LS(0.048)QDQAATSK 101.87 8.7537e-09 145959000.0 211664.0 205934.0 224727.0 232493.0 248897.0 178732.0 171230.0 187842.0 150867.0 200965.0 True False 199900.56223812647 221728.4756178242 210268.30948425713 200827.0523272045 217628.33369258814 203350.71063244535 179192.53428580816 188388.5891210827 181044.61557618328 195162.61828022293 1.0242769030240237 1.136121648560058 1.0774005357027174 1.029024175310296 1.115112799829873 1.0419552290514242 0.9181703743516895 0.9652903347022441 0.9276603130842997 1.0 17.574317217981225 -7.109248563311457 4.555835208042739 0.9506257863973918 1.0773286771732637 0.7031841057362899 0.037970318079177126 0.119834546515061 4.007250330537773 0.014233843940340715 0.01098294303838976 7.775913784264042e-08 7.109248563311457 0.12670289077587193 EVAATEEDVTRLPSPT(ph)SPFSSLSQDQAATSK ddPTM_A459_Selumetinib_30min_R2 1 EVAATEEDVTRLPSPTSPFSSLSQDQAATSK 31 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 EVAATEEDVT(0.005)RLPS(0.182)PT(0.243)S(0.243)PFS(0.089)S(0.118)LS(0.118)QDQAATSK 68.291 0.00037205 82473000.0 29483.0 24386.0 27476.0 41153.0 32043.0 23470.0 24559.0 26155.0 23562.0 22265.0 True False 27844.45288980024 26256.327786651305 25708.224073606896 35547.89040711528 28017.471871945436 26702.77946055262 25701.042162735284 26231.106719806674 28275.05837728621 21622.151598582655 1.2877743809559388 1.2143253952752984 1.1889762198916451 1.6440496333142658 1.2957763127413275 1.2349732790839836 1.1886440646554344 1.2131589495249926 1.3076893966065641 1.0 14.400222470899399 -6.79635629958633 3.662683551220578 1.1984588745368006 1.3312560314079707 0.20564832579940107 0.13645416822552464 0.44169485134407943 12.413753926086697 0.05113290350065855 0.04664073523253158 1.598246273188952e-07 6.79635629958633 0.1327971568711701 EVAATEEDVTRLPSPTS(ph)PFSSLSQDQAATSK ddPTM_A459_Selumetinib_30min_R1 1 EVAATEEDVTRLPSPTSPFSSLSQDQAATSK 31 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 EVAATEEDVTRLPS(0.123)PT(0.046)S(0.689)PFS(0.093)S(0.035)LS(0.013)QDQAATSK 88.48100000000002 4.9762e-07 81478000.0 4059.8 4941.4 5377.8 5430.0 4764.3 4231.4 4558.7 4903.6 2527.5 3446.4 True False 4154.385441004346 4362.858590805466 4647.524298140901 4481.752433723935 4333.369906205484 4188.835957803804 4214.833588769575 4773.540598862399 4288.9828987038145 3888.7790107788187 1.068300726137774 1.1219096222008516 1.1951114437871144 1.1524831885024907 1.1143266033359982 1.0771596807618267 1.0838449747560883 1.2275165509871404 1.1029124789080893 1.0 11.925101537147714 -6.390638031597189 6.799453192994936 1.1099508867059464 1.137765813450665 0.05661564379755912 0.06025170033402674 0.9787989378455977 49.84610899687566 0.019235840278845784 0.021803266956790083 4.067822258706825e-07 6.390638031597189 0.027814926744718527 EVAEAATGEDASSPPPKT(ph)EAASDPQHPAASEGAAAAAASPPLLR ddPTM_A459_Selumetinib_30min_R2 1 EVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAASPPLLR 44 1 K7ERT7;Q99536-3;Q99536 K7ERT7 VAT1 Synaptic vesicle membrane protein VAT-1 homolog 1 EVAEAAT(0.001)GEDAS(0.154)S(0.154)PPPKT(0.481)EAAS(0.21)DPQHPAASEGAAAAAASPPLLR 76.82600000000002 6.2496e-10 21645000.0 10917.0 9941.8 11484.0 14117.0 11021.0 10447.0 11767.0 11988.0 9341.5 11155.0 True False 10310.276844213591 10704.304092074553 10745.131942833796 12194.24024681668 9636.44345100991 11885.97942157619 12314.188815868156 12022.88309527977 11210.06102331802 10832.926165829303 0.9517536339106303 0.9881267469393018 0.9918956132764534 1.125664484382938 0.8895512905281768 1.0972085694693066 1.1367370761476483 1.1098463066427973 1.0348137568479259 1.0 13.403135372700635 EVAENQQNQS(ph)SDPEEEK ddPTM_A459_Selumetinib_30min_R2 1 EVAENQQNQSSDPEEEK 17 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 EVAENQQNQS(0.971)S(0.029)DPEEEK 265.6 4.958299999999999e-41 3764000.0 65559.0 41609.0 61686.0 59172.0 55177.0 55192.0 81790.0 69869.0 59236.0 42340.0 True False 61915.49323347061 44800.276505977774 57717.189918638585 51112.67152260652 48245.17197136138 62794.19701690758 85593.3970638104 70072.30722256434 71084.8551921283 41117.534187468664 1.5058172737493707 1.0895662250007077 1.4037123348760776 1.2430869830269167 1.1733478897687644 1.5271878106942824 2.0816763153539637 1.7041952686919681 1.7288209664526222 1.0 15.327466128464085 -6.966328377792866 6.262588821754682 1.7036485069090002 1.2813597976060156 0.2487034942492522 0.2746684999035309 0.1959619007182936 22.4340106180897 0.09276755056380083 0.08062363002193901 1.0806165688838833e-07 6.966328377792866 -0.42228870930298457 EVAENQQNQS(ph)SDPEEEKGSQPPPAAESQSSLRR ddPTM_A459_Selumetinib_30min_R2 1 EVAENQQNQSSDPEEEKGSQPPPAAESQSSLRR 33 2 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 EVAENQQNQS(0.487)S(0.487)DPEEEKGS(0.025)QPPPAAESQSSLRR 90.388 5.1447e-09 9625800.0 26459.0 33297.0 27164.0 27289.0 20956.0 16024.0 14270.0 15688.0 10758.0 24798.0 True False 24988.51470376909 35850.77283327026 25416.297813926965 23572.19112384928 18323.319930983016 18231.160548610784 14933.58327546857 15733.649482711799 12909.900603634884 24082.017307058282 1.0376420872534262 1.4886947541044508 1.0554056784303372 0.9788295898674744 0.7608714709133845 0.7570445746365007 0.6201134682804017 0.6533360258860195 0.5360805300912675 1.0 14.55566862866483 -5.966058353832047 1.3616089785154764 0.6840194211239772 1.2650690047136428 0.6494779765653865 0.158424598837422 0.23628132766818755 0.8890913188656681 0.05352926799623425 0.10121570760085999 1.081288654550254e-06 5.966058353832047 0.5810495835896656 EVAENQQNQSSDPEEEKGSQPPPAAES(ph)QSSLRR ddPTM_A459_Selumetinib_30min_R1 3 EVAENQQNQSSDPEEEKGSQPPPAAESQSSLRR 33 2 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 EVAENQQNQSSDPEEEKGSQPPPAAES(0.333)QS(0.333)S(0.333)LRR;EVAENQQNQSSDPEEEKGS(0.001)QPPPAAES(0.333)QS(0.333)S(0.333)LRR;EVAENQQNQSSDPEEEKGSQPPPAAES(0.333)QS(0.333)S(0.333)LRR 93.759 8.337699999999999e-10 56525500.0 6789.15 6131.589999999999 5870.2 6841.889999999999 5856.4800000000005 5573.13 6247.250000000001 6756.16 3389.36 5840.860000000001 True False 6947.323985613737 5413.700592301145 5073.059082700493 5647.08234968167 5326.762418045527 5517.06937219717 5776.01490281017 6576.964689699442 5751.496370939967 6590.591275794323 1.0541275729128596 0.8214286648580957 0.7697426331583683 0.8568400183488942 0.8082374092305588 0.8371129601770414 0.8764031421617815 0.9979324182725564 0.8726829096599947 1.0 12.686192187283918 -7.600995526389818 5.995625560295583 0.9507450776064521 0.850444159277345 0.23836693254642904 0.0785030224755478 0.2992566669705711 17.684706792796757 0.03735887359018039 0.021282019866933354 2.5061350682659746e-08 7.600995526389818 -0.10030091832910715 EVAENQQNQSSDPEEEKGSQPPPAAESQSS(ph)LRR ddPTM_A459_Selumetinib_30min_R2 1 EVAENQQNQSSDPEEEKGSQPPPAAESQSSLRR 33 2 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 EVAENQQNQSSDPEEEKGSQPPPAAES(0.022)QS(0.206)S(0.772)LRR 81.765 1.3161000000000002e-06 46284000.0 61014.0 66333.0 65641.0 67157.0 59727.0 47843.0 62184.0 56083.0 48787.0 53468.0 True False 57623.086138394065 71420.52780578787 61417.72952451709 58010.10074771322 52223.56029384527 54432.938974487384 65075.67921525836 56246.19224495955 58545.76322267477 51924.239913452395 1.1097530986383342 1.375475653082876 1.1828334825293254 1.1172065463915268 1.005764559691038 1.0483146034533486 1.2532813060668169 1.0832357361169083 1.1275227778058796 1.0 15.664120572061474 -5.643234262274276 3.575685208883763 1.095285797250618 1.2494632097687037 0.317825682671503 0.09048471270999729 0.2596984612096972 6.353185724137057 0.02501827454990524 0.046158690071789715 2.273870554073996e-06 5.643234262274276 0.1541774125180857 EVAES(ph)PRPR ddPTM_A459_Selumetinib_30min_R1 1 EVAESPRPR 9 1 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 EVAES(1)PRPR 79.036 0.027476 6323700.0 2291.2 2709.1 3003.7 3333.9 3536.4 2569.7 2843.0 2139.1 1535.3 2431.5 True False 2344.5805021008814 2391.9173125735783 2595.8140381430735 2751.6969500538166 3216.5332444021287 2543.8511511009197 2628.550221087568 2082.3641192239475 2605.291966124615 2743.6067098156627 0.8545614404983026 0.8718149376206644 0.9461319761524716 1.0029487609172298 1.1723740260929165 0.9271923493990273 0.9580637821315777 0.7589878358927972 0.9495865266708213 1.0 11.421857973729567 -10.630102636875025 14.16809663349796 0.9999999941901603 0.9400734873895635 0.032080766589864695 0.10163521578883694 0.0 0.0 0.10663621355137062 0.025863080512494592 2.343674868859202e-11 10.630102636875025 -0.059926506800596746 EVCGFAPYER ddPTM_A459_Selumetinib_30min_R2 2 EVCGFAPYER 10 0 J3QSB5;Q9Y3U8 J3QSB5 RPL36 60S ribosomal protein L36 0 ; 140.17 0.020049 7630700.0 32164.0 23514.0 28402.0 34796.0 38479.0 21860.3 24182.0 26632.0 24313.0 30107.0 False True 30376.45364269359 25317.44819057323 26574.64624175944 30056.724773551945 33644.924013375414 24871.357896954352 25306.51091572395 26709.494710835053 29176.279361979443 29237.732682619706 1.0389469652942955 0.865916945934153 0.9089161095434966 1.0280114774911766 1.1507364260627346 0.8506595968619368 0.8655428651198845 0.9135282479243831 0.9978981502667341 1.0 14.835543817571386 -9.775939353887702 15.286338121982947 0.9999963653194123 0.9542288830127691 0.017568860253452057 0.09123806128738753 0.0 0.0 0.09326043235295578 0.022618977251882784 1.675176786128197e-10 9.775939353887702 -0.04576748230664318 EVDAT(ph)SPAPSTSSTVK ddPTM_A459_Selumetinib_30min_R2 1 EVDATSPAPSTSSTVK 16 0 Q16666-3;Q16666-2;Q16666;H3BM18;X6RHM1;Q16666-6 Q16666-3 IFI16 Gamma-interferon-inducible protein 16 1 EVDAT(0.669)S(0.323)PAPS(0.003)T(0.003)S(0.001)STVK 120.03 0.0038263 5479400.0 36502.0 26777.0 40036.0 34915.0 33886.0 24694.0 31532.0 35066.0 26432.0 30728.0 True False 34473.36496908348 28830.70979837458 37460.1273479009 30159.51676826551 29628.937735316395 28095.374350186903 32998.300479472666 35168.03625451119 31719.13857178633 29840.80279906796 1.1552425449545953 0.9661506090337179 1.2553324252077738 1.0106804757011263 0.992900155361833 0.9415086631337019 1.1058114187364734 1.178521787477166 1.062945215829684 1.0 14.864998728100199 -9.691813318302486 0.00562094606420707 2.9207581412551404e-07 2.0971978580876525 0.03568378524560556 0.09635878051210806 71308.95088336057 110.30224873334734 21043.250274329897 20111.003230975704 2.0332308083886898e-10 9.691813318302486 2.0971975660118383 EVDATSPAPS(ph)TSSTVK ddPTM_A459_Selumetinib_30min_R2 1 EVDATSPAPSTSSTVK 16 0 Q16666-3;Q16666-2;Q16666;H3BM18;X6RHM1;Q16666-6 Q16666-3 IFI16 Gamma-interferon-inducible protein 16 1 EVDAT(0.008)S(0.086)PAPS(0.561)T(0.266)S(0.062)S(0.015)T(0.002)VK 114.76 0.0020534000000000004 4506800.0 27666.0 26985.0 29096.0 28492.0 30932.0 19014.0 22157.0 20302.0 19992.0 22763.0 True False 26128.434475772927 29054.66272954915 27223.995037329536 24611.340448558523 27046.045624411454 21633.005908093193 23187.344403262592 20361.075458822965 23990.958623151946 22105.773044623267 1.18197334348043 1.3143472825355929 1.2315332733388016 1.1133444824063585 1.2234833665312508 0.9786134085618389 1.0489270995615507 0.921075024959389 1.0852802376430444 1.0 14.432135566143783 -6.564055244424878 1.2003560611738278 0.9967089573953266 1.240459658152467 0.6737587931608806 0.0685395626408337 0.25341843806425207 0.7682949498358654 0.030392702638970155 0.03308483936793778 2.728630665296671e-07 6.564055244424878 0.24375070075714034 EVDDLEQWIAER ddPTM_A459_Selumetinib_30min_R1 4 EVDDLEQWIAER 12 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 ;;; 151.55 0.007197199999999998 11585900.0 5605.1 6170.4 6597.3 7239.3 6261.799999999999 6054.200000000001 6103.6 5804.2 3596.4 4779.28 False True 5735.687924373975 5447.966699458867 5701.422896374902 5975.092153491289 5695.42129561058 5993.3002447737845 5643.200537963447 5650.253761301314 6102.828129336656 5392.747142129461 1.063592965367387 1.010239596976097 1.0572390557372864 1.1079867080754455 1.05612615342495 1.1113631117529423 1.0464426366067459 1.0477505457580512 1.1316733324393922 1.0 12.396804674277641 -5.519123266232061 24.89073683135768 1.0742667575151006 1.0361220377915734 0.11348344657145892 0.038151233258369055 252.1813068494786 1671417.2375297293 0.009641354893206546 0.01715879125568385 3.0260544181837513e-06 5.519123266232061 -0.038144719723527176 EVDDLEQWIAER ddPTM_A459_Selumetinib_30min_R2 2 EVDDLEQWIAER 12 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 ; 151.55 0.007197199999999998 5966000.0 16739.9 15898.699999999999 15668.2 19023.6 20027.3 14336.0 12521.5 15701.5 13237.6 17378.2 False True 15809.563373129155 17118.079167622134 14660.125070246306 16432.552862459568 17511.291527666337 16310.653870749136 13103.77456088154 15747.188765476752 15885.489889447586 16876.446212013878 0.9367827310630576 1.0143177629088904 0.8686737057124128 0.9736974630809232 1.0376172392977219 0.9664744381514415 0.7764534307912127 0.933086774765813 0.9412816946105125 1.0 14.042723517475881 -7.068419181053382 24.99996186455719 0.90203430210801 0.9677047092549749 0.12305170877639393 0.06762559263934696 315.60513354083866 115318.74201181048 0.025743338177876662 0.019940711483452306 8.542418006218334e-08 7.068419181053382 0.06567040714696482 EVDDLGPEVGDIK ddPTM_A459_Selumetinib_30min_R2 1 EVDDLGPEVGDIK 13 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 142.07 0.011013 1956900.0 19721.0 16632.0 15372.0 16036.0 21571.0 13008.0 16981.0 12530.0 12315.0 13110.0 False True 18624.98576941798 17907.620919691 14382.982255768125 13851.869136357032 18861.05813281325 14799.733925132861 17770.650147213153 12566.46022554684 14778.34410984974 12731.480236129288 1.4629081162584814 1.406562362550185 1.1297179895038614 1.0880014640440876 1.4814505291607412 1.1624519420086206 1.3958039299141156 0.987038426991847 1.1607718690802253 1.0 13.63611254467825 -1.5228787455602861 0.076577078277339 0.7627896356217363 2.4099078730937724 0.34983144511450415 0.14593920474551503 260.18960724071786 1.4647837858890034 5.0018070687801535 45.58698132837245 0.02999999998066184 1.5228787455602861 1.6471182374720361 EVDEDFDSK ddPTM_A459_Selumetinib_30min_R2 4 EVDEDFDSK 9 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 ;;; 156.35 0.011621 20926000.0 177998.0 164507.0 171038.0 181334.0 178666.0 133259.0 161889.0 159822.0 120706.0 166226.0 False True 168105.58374245014 177124.15792662362 160033.6012920941 156635.99638140228 156220.3797856944 151614.21764523984 169417.159276968 160287.05556004375 144850.57280743195 161426.6234729842 1.041374589431239 1.0972425372960024 0.9913705549250788 0.9703231908806934 0.9677485437328675 0.9392144516397783 1.0494994916704126 0.9929406445577351 0.8973152612070439 1.0 17.300519010827607 -5.371256261671472 5.0903473562512085 0.9755058267923438 1.0686393368197986 0.47560013049965844 0.03941276609585521 0.1817200326648775 6.918880654261986 0.01046059987004737 0.02254741574626189 4.253473567790238e-06 5.371256261671472 0.09313351002745485 EVDEDS(ph)EPER ddPTM_A459_Selumetinib_30min_R1 2 EVDEDSEPER 10 0 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EVDEDS(1)EPER;EVDEDS(1)EPER 132.86 0.0023684 23155000.0 11494.7 14951.2 9704.599999999999 9603.3 10797.900000000001 10890.5 12305.300000000001 12220.199999999999 5928.7 9544.9 True False 11762.50414520731 13200.706553375685 8386.768623552045 7926.263931267237 9821.231851524088 10780.951457782849 11377.101313946136 11896.080599196159 10060.570884884393 10770.080890199266 1.0921463139530498 1.225683139054998 0.77870990097985 0.7359521262723392 0.9118995438986325 1.0010093301707208 1.0563617330208965 1.1045488627686677 0.934122128464186 1.0 13.3947414650352 -10.307320055808308 13.930022332880144 1.000013959086477 0.980454819762239 0.001255049879092307 0.14195940301749616 0.0 0.0 0.15178578404175516 0.036813460004196955 4.928104905820583e-11 10.307320055808308 -0.019559139324237917 EVDEDS(ph)EPER ddPTM_A459_Selumetinib_30min_R2 3 EVDEDSEPER 10 0 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EVDEDS(1)EPER;EVDEDS(1)EPER;EVDEDS(1)EPER 147.24 0.00083207 195369000.0 58626.7 48109.1 58511.6 63431.3 65363.4 60446.3 52022.1 60324.0 62598.3 57529.8 True False 55368.46271527491 51798.91327486208 54747.0273586132 54791.84751490418 57151.865335789975 68772.22914812101 54441.230729835566 60499.53285282418 75119.70914263971 55868.76519362855 0.9910450414176919 0.9271533583271212 0.9799219146668509 0.9807241546328791 1.0229663236284978 1.2309602496094547 0.974448433595311 1.082886522427092 1.3445743588978873 1.0 15.769754313879066 -6.53615577094798 21.791835749276977 1.122770754266118 0.9717061460954772 0.35273372059544994 0.10103093283995329 58.541060641409196 96081.61997333138 0.032866394913197185 0.032900899541084376 2.9096733013002196e-07 6.53615577094798 -0.15106460817064082 EVDEDS(ph)EPEREVR ddPTM_A459_Selumetinib_30min_R2 1 EVDEDSEPEREVR 13 1 F8WC91;B9A018;Q53GS9-3;Q53GS9 F8WC91 USP39 U4/U6.U5 tri-snRNP-associated protein 2 1 EVDEDS(1)EPEREVR 65.51100000000001 0.041628 9354100.0 15959.0 20678.0 19372.0 20489.0 29922.0 16137.0 6763.2 7522.9 7411.3 16934.0 True False 15072.06266893878 22263.936109750503 18125.626610638836 17698.36285450357 26162.930853926 18359.725272898922 7077.702201026558 7544.790393516864 8893.767089023902 16445.071420184082 0.9165094078241508 1.353836389085216 1.1021920274783423 1.0762107626228516 1.5909283812422104 1.11642721419652 0.4303844002975654 0.45878732908734365 0.5408165681851655 1.0 14.005367653294163 -7.190578351211199 5.580391930417438 0.5634221335053112 1.2143546830920173 0.6172520927967313 0.2249653133904609 0.13265375175988528 7.697974355317056 0.08492854188969873 0.06503934393143762 6.447949816980902e-08 7.190578351211199 0.6509325495867061 EVDEQMLNVQNK ddPTM_A459_Selumetinib_30min_R1 5 EVDEQMLNVQNK 12 0 P68371;P07437;Q5JP53;Q5ST81;Q9BVA1;Q13885 P68371;P07437;Q9BVA1 TUBB4B;TUBB;TUBB2B;TUBB2A Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-2B chain;Tubulin beta-2A chain 0 ;;;; 294.93 2.5739e-54 192997700.0 15325.100000000002 15518.099999999999 14775.0 16547.8 14054.8 12808.5 13557.2 12136.2 8325.6 11515.099999999999 False True 15682.145012546353 13701.233637831026 12768.636153265608 13658.037370677146 12783.545821576472 12679.6581191875 12534.569489035657 11814.308552066614 14127.935122234814 12993.175251572407 1.2069524738110904 1.0544946383427662 0.9827186893150213 1.0511701032451077 0.9838661892926776 0.9758706300565778 0.9647041039886497 0.9092703148629409 1.087335070041873 1.0 13.665466416948988 EVDEQMLNVQNK ddPTM_A459_Selumetinib_30min_R2 3 EVDEQMLNVQNK 12 0 P68371;P07437;Q5JP53;Q5ST81;Q9BVA1;Q13885 P68371;P07437;Q9BVA1 TUBB4B;TUBB;TUBB2B;TUBB2A Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-2B chain;Tubulin beta-2A chain 0 ;; 267.29 7.284899999999996e-107 20471500.0 151388.0 166275.0 178567.0 169620.0 191888.0 131245.0 154090.0 149586.0 141899.0 162761.0 False True 142974.46101418024 179027.75784160758 167078.1936290497 146517.46338917923 167781.31393951454 149322.80742651154 161255.49032354238 150021.2704947047 170282.7649893274 158061.66702613587 0.9045486088068341 1.1326450062810292 1.0570443597904287 0.9269639258261918 1.061492752140666 0.9447123406703073 1.02020618507635 0.9491312683036446 1.0773185440412365 1.0 17.270128003444 EVDGLLTS(ph)EPMGSPVSSK ddPTM_A459_Selumetinib_30min_R1 1 EVDGLLTSEPMGSPVSSK 18 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EVDGLLT(0.01)S(0.674)EPMGS(0.303)PVS(0.009)S(0.003)K 93.345 0.017636000000000002 7916900.0 1518.3 1224.9 1450.1 1455.3 1288.2 900.99 1262.1 1314.4 783.6 1136.5 True False 1553.6734359024815 1081.488138559439 1253.1843848291337 1201.1591743643546 1171.6825374501825 891.9268586334663 1166.8987808774598 1279.537842227085 1329.7119681203992 1282.3808454474606 1.211553838641717 0.8433439585430456 0.9772326132895884 0.9366633778323745 0.9136775097738986 0.6955241586770946 0.9099471385743401 0.9977830273818667 1.0369087879322023 1.0 10.324609066308717 -11.088398187724476 14.522293957395645 1.0000000311102177 0.9365316181179586 0.009667724495009633 0.1261422616457828 1.2762050472707167e-07 3.776890047892527e-09 0.12269531651277786 0.029757970646348043 8.158340218508742e-12 11.088398187724476 -0.06346841299225914 EVDGLLTSEPMGS(ph)PVSSK ddPTM_A459_Selumetinib_30min_R1 15 EVDGLLTSEPMGSPVSSK 18 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EVDGLLTSEPMGS(0.999)PVSSK;EVDGLLTSEPMGS(1)PVSSK;EVDGLLTS(0.001)EPMGS(0.999)PVS(0.001)SK;EVDGLLTS(0.001)EPMGS(0.996)PVS(0.001)S(0.001)K;EVDGLLTSEPMGS(1)PVSSK;EVDGLLTS(0.124)EPMGS(0.876)PVSSK;EVDGLLTS(0.01)EPMGS(0.96)PVS(0.024)S(0.005)K;EVDGLLT(0.001)S(0.015)EPMGS(0.951)PVS(0.026)S(0.008)K;EVDGLLTSEPMGS(0.996)PVS(0.003)S(0.001)K;EVDGLLTSEPMGS(1)PVSSK;EVDGLLTS(0.004)EPMGS(0.974)PVS(0.017)S(0.006)K;EVDGLLTSEPMGS(1)PVSSK;EVDGLLTSEPMGS(1)PVSSK;EVDGLLT(0.002)S(0.022)EPMGS(0.975)PVSSK;EVDGLLTSEPMGS(0.989)PVS(0.01)S(0.001)K 362.61 3.023599999999997e-206 471949500.0 51104.48000000001 54907.7 52585.380000000005 53388.49999999999 51417.91 46001.17 50535.3 48189.5 27392.979999999996 40930.39 True False 52295.114951992175 48479.080958102786 45444.57422681625 44065.20070126525 46767.16911906933 45538.43999552054 46723.38163479654 46911.35791844351 46483.88635589933 46184.20425226068 1.1323160331258142 1.0496896448254767 0.9839852166467018 0.9541184353979271 1.0126226028194503 0.9860176381255171 1.0116744976180783 1.0157446399251804 1.0064888441511686 1.0 15.495111890422473 -4.881303535833965 2.607833341264789 0.9964174928743852 1.1453244214612832 0.8479363975182446 0.017779853942170788 0.14807920435118513 1.5599025528398391 0.0050497390735233325 0.04454797148940805 1.314305920243498e-05 4.881303535833965 0.14890692858689802 EVDGLLTSEPMGS(ph)PVSSK ddPTM_A459_Selumetinib_30min_R2 19 EVDGLLTSEPMGSPVSSK 18 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 EVDGLLTSEPMGS(1)PVSSK;EVDGLLTSEPMGS(0.984)PVS(0.012)S(0.003)K;EVDGLLTSEPMGS(0.942)PVS(0.051)S(0.007)K;EVDGLLTS(0.001)EPMGS(0.989)PVS(0.008)S(0.002)K;EVDGLLT(0.005)S(0.046)EPMGS(0.942)PVS(0.005)S(0.001)K;EVDGLLTSEPMGS(0.998)PVS(0.002)SK;EVDGLLT(0.001)S(0.037)EPMGS(0.827)PVS(0.114)S(0.021)K;EVDGLLTSEPMGS(0.994)PVS(0.004)S(0.002)K;EVDGLLTS(0.006)EPMGS(0.991)PVS(0.002)SK;EVDGLLTS(0.006)EPMGS(0.973)PVS(0.016)S(0.005)K;EVDGLLTSEPMGS(0.999)PVS(0.001)SK;EVDGLLTS(0.001)EPMGS(0.961)PVS(0.03)S(0.008)K;EVDGLLT(0.001)S(0.029)EPMGS(0.968)PVS(0.002)SK;EVDGLLTS(0.001)EPMGS(0.991)PVS(0.006)S(0.001)K;EVDGLLTSEPMGS(0.997)PVS(0.002)S(0.001)K;EVDGLLT(0.001)SEPMGS(0.99)PVS(0.007)S(0.002)K;EVDGLLTSEPMGS(0.99)PVS(0.007)S(0.003)K;EVDGLLTSEPMGS(1)PVSSK;EVDGLLT(0.066)S(0.012)EPMGS(0.883)PVS(0.03)S(0.009)K 244.18 1.7242999999999996e-25 350528600.0 971781.0 945164.6 1000114.8 1097512.3 1111565.4 864610.0 860891.5 904879.7 763885.0 1031481.7 True False 917773.3023675655 1017655.685636809 935768.5026106602 948029.231425679 971920.616931241 983702.1793518693 900924.6605741445 907512.7501161023 916683.3447302114 1001700.1432096878 0.916215604628746 1.0159284617610174 0.9341802623809489 0.9464201815804536 0.9702710172497071 0.9820325833236394 0.8993955593211412 0.9059724671778657 0.9151274969303068 1.0 19.93401927481625 -7.259008039664561 24.987570469379538 0.9222882533834728 0.961906556871511 0.1308083977532296 0.03656541946331477 337.26220672531434 3466175.685649966 0.013734058721648247 0.010097540524998321 5.507974999412228e-08 7.259008039664561 0.0396183034880383 EVDKT(ph)PPPQPPLISSMDSISQK ddPTM_A459_Selumetinib_30min_R2 2 EVDKTPPPQPPLISSMDSISQK 22 1 Q92625;A0A3B3ISP1;A0A3B3ITU5 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 EVDKT(1)PPPQPPLISSMDSISQK;EVDKT(1)PPPQPPLISSMDSISQK 100.7 0.0025112 5183000.0 48240.0 48105.0 49567.0 46835.0 48400.0 39024.5 49137.0 44953.0 37849.0 45464.0 True False 45559.01392002048 51794.498818045664 46377.91318446906 40455.992205118564 42319.55929851012 44399.77064586004 51421.967863118334 45083.80578763021 45419.85758941968 44151.336190341855 1.031883015354506 1.1731128270898346 1.0504305687268025 0.9163027825637664 0.9585114053188624 1.0056268841886722 1.1646752352280323 1.0211198499920449 1.0287312119753085 1.0 15.430169479620462 -5.515195814094691 24.937780082535205 1.0154449564508865 1.1048163774744413 0.21456709677186714 0.06772564252700336 520.6067725871666 1689817.8331789793 0.019461875099545417 0.03572464287689815 3.053544025086854e-06 5.515195814094691 0.08937142102355478 EVDPSTGELQSLQMPES(ph)EGPSSLDPSQEGPTGLK ddPTM_A459_Selumetinib_30min_R1 2 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLK 34 0 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 EVDPSTGELQSLQMPES(0.771)EGPS(0.114)S(0.114)LDPSQEGPTGLK;EVDPSTGELQSLQMPES(0.451)EGPS(0.275)S(0.275)LDPSQEGPTGLK 146.6 2.1466e-27 14327500.0 3790.3 3652.0 4722.7 4436.1 4206.5 3827.9 3550.2 3710.3 2369.2799999999997 2944.8 True False 3878.6066153600614 3224.4221422312608 4081.383279934177 3661.418410910266 3826.0228177178947 3789.3948014551165 3282.4055557175825 3611.8907912470763 4020.4951146353987 3322.793764781067 1.1672727499582316 0.9703949057589834 1.228298705503046 1.1019096188630024 1.1514475735059606 1.1404243145089665 0.9878451050764671 1.0870042039714305 1.2099743165674028 1.0 11.698181036987569 EVEDKES(ph)EGEEEDEDEDLSK ddPTM_A459_Selumetinib_30min_R1 6 EVEDKESEGEEEDEDEDLSK 20 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(0.998)EGEEEDEDEDLS(0.002)K;EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(1)EGEEEDEDEDLSK 111.65 0.0001905 625203100.0 12788.06 16436.13 13979.549999999997 15724.03 10330.8 13564.21 12731.390000000001 12843.399999999998 9997.0 15797.509999999998 True False 13085.996916766839 14511.78025865046 12081.203894171525 12978.123337099114 9396.38096405088 13427.766362717284 11771.051002199109 12502.751310757261 16964.17884800873 17825.27428927822 0.7341259777774066 0.8141125922185218 0.6777569701375248 0.7280742571745652 0.5271380855947188 0.7532992841963725 0.6603573561434236 0.7014058301631623 0.9516924437012769 1.0 14.121636656091649 -8.298998299579297 4.102810370613252 0.9933681129173761 0.6973435720328247 0.7105742689461858 0.07077851436267292 0.1178809881741743 4.245931698092378 0.06626477306738138 0.0184156699275975 5.0234455638000745e-09 8.298998299579297 -0.29602454088455143 EVEDKES(ph)EGEEEDEDEDLSK ddPTM_A459_Selumetinib_30min_R2 4 EVEDKESEGEEEDEDEDLSK 20 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(1)EGEEEDEDEDLSK;EVEDKES(1)EGEEEDEDEDLSK 148.19 1.0785e-05 1086380000.0 589746.0 528661.0 465669.0 420396.0 331928.0 308663.0 425190.0 365928.0 240079.0 353751.0 True False 556970.2782602893 569207.5987869637 435708.3635220713 363137.3395764504 290228.23716602987 351178.526486261 444962.1774980011 366992.7898973581 288101.5083677319 343537.28947452037 1.6212804121271351 1.6569019324150573 1.268300056126475 1.0570536320290311 0.8448230979814948 1.0222428168523678 1.2952369106090977 1.0682764321122624 0.8386324198121727 1.0 18.390107180234565 -5.452265116451879 2.422984029299148 1.0246714474721668 1.652324937028618 0.8057535142340827 0.12113225536069051 0.13339602487256738 1.5164299974197926 0.0371349514162421 0.09465530681223898 3.529676337933141e-06 5.452265116451879 0.6276534895564512 EVEDKES(ph)EGEEEDEDEDLSKYK ddPTM_A459_Selumetinib_30min_R2 1 EVEDKESEGEEEDEDEDLSKYK 22 2 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 EVEDKES(1)EGEEEDEDEDLSKYK 67.655 0.0064062 4878300.0 13543.0 15358.0 11807.0 11947.0 9302.1 5326.5 6211.6 3901.1 3321.4 10085.0 True False 12790.334276924483 16535.90921624665 11047.350474489609 10319.797990275465 8133.487036170886 6060.177025847192 6500.451708051898 3912.45155513813 3985.772807669909 9793.81984602318 1.3059597254199085 1.6884024289012345 1.1279920039549667 1.0537051071514105 0.8304713752186815 0.6187756280107554 0.6637299654527986 0.3994816748366876 0.4069681564837389 1.0 13.257655943069457 -5.985691042098338 0.9850527620557814 0.5649393072443902 1.5225788430157923 0.749952604311369 0.19395261367405706 0.26537558431764235 0.5207796920983903 0.07949296442493523 0.17518771901869815 1.0334963755435173e-06 5.985691042098338 0.957639535771402 EVEEDEYK ddPTM_A459_Selumetinib_30min_R1 2 EVEEDEYK 8 0 P14625 P14625 HSP90B1 Endoplasmin 0 ; 152.63 0.013488 23267000.0 6633.9 7103.9 7324.200000000001 7966.400000000001 6855.700000000001 6984.6 7168.9 7064.7 4326.0 6134.3 False True 6788.45696267765 6272.172085486489 6329.613868950797 6575.217787848683 6235.603145472145 6914.341265509392 6628.144101285495 6877.3212066202705 7340.90604146101 6921.6971581419775 0.9807503575466897 0.9061610096749966 0.914459810121176 0.9499430035181861 0.9008777765056101 0.9989372703739381 0.9575894393889832 0.9935888626000478 1.060564464717431 1.0 12.756910105968318 -7.473609779475038 1.0551981042698726 1.026459180087272 0.9308950290875752 0.551641569659912 0.032090167852678805 0.38278998314165924 0.7955368636496775 0.024455879960844706 0.011762432873749123 3.3603941541526704e-08 7.473609779475038 -0.09556415099969684 EVEKQEDTENHPKT(ph)PESAPENK ddPTM_A459_Selumetinib_30min_R2 1 EVEKQEDTENHPKTPESAPENK 22 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 EVEKQEDT(0.006)ENHPKT(0.809)PES(0.185)APENK 59.469 0.022115 5506900.0 29300.0 24461.0 24223.0 21544.0 18337.0 17923.0 23053.0 17884.0 13244.0 24898.0 True False 27671.623297193175 26337.0800454883 22664.518552008274 18609.670034527066 16033.342125140074 20391.73056120514 24125.01017865289 17936.039479144412 15893.170068278529 24179.130047227078 1.1444424693173205 1.0892484549297794 0.9373587266266222 0.7696583788655071 0.6631066582554246 0.8433608041883919 0.9977617115062254 0.7417983791853322 0.6573094249973314 1.0 14.56147471763816 -5.402327513759349 2.428467727870166 0.8033852814701589 1.130175896253871 0.540831974489045 0.11223344762059075 0.2313715895462861 2.6087934560186716 0.03256189923720445 0.08838932230270319 3.9597930243034714e-06 5.402327513759349 0.3267906147837122 EVELVS(ph)E ddPTM_A459_Selumetinib_30min_R1 1 EVELVSE 7 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 EVELVS(1)E 84.568 0.037361 4744400.0 8292.3 11052.0 10859.0 11548.0 10385.0 9669.0 10010.0 9365.7 5461.3 8106.0 True False 8485.494455992983 9758.026702064599 9384.407444217344 9531.358582807372 9445.678583620669 9571.738638749577 9254.937640902768 9117.291211918904 9267.427222429731 9146.484059126366 0.9277329300679372 1.0668609532345967 1.0260125512221911 1.0420789585586145 1.032711424691739 1.04649377584591 1.0118574067450747 0.996808298465427 1.0132229130364785 1.0 13.15900155753771 -9.934244247503003 9.438760563792696 0.999998946756253 1.0210047354225724 0.01745075656900097 0.03576039595064356 0.0 0.0 0.03314671800165577 0.008039259968434654 1.1634715082327317e-10 9.934244247503003 0.021005788666319414 EVELVS(ph)E ddPTM_A459_Selumetinib_30min_R2 2 EVELVSE 7 0 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 EVELVS(1)E;EVELVS(1)E 122.74 0.0077518 16742600.0 312810.0 299970.0 349990.0 359750.0 388350.0 281060.0 316090.0 316860.0 268350.0 306980.0 True False 295425.2724776452 322976.7344444275 327472.02444029914 310751.4293966356 339562.0011069505 319773.46379134705 330788.8113204525 317782.0101410033 322027.49832547054 298116.6897701727 0.9909719335250824 1.0833903150253685 1.0984692762178372 1.0423818593860124 1.1390237875267208 1.0726452921433893 1.109595076932686 1.0659651775483996 1.0802062057435677 1.0 18.185517619892195 -4.76064896187507 24.840362741455245 1.0813472381517788 0.9909718227003852 0.33404500065605125 0.035876414282681374 18.291514333733147 574456.0121526279 0.008157549817452453 0.047477656974657174 1.7352059896580035e-05 4.76064896187507 -0.0903754154513936 EVEPEPTEDKDLEADEEDTR ddPTM_A459_Selumetinib_30min_R1 1 EVEPEPTEDKDLEADEEDTR 20 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 121.51 0.00069339 14031000.0 1705.4 2536.5 2727.1 2519.3 3091.8 3380.7 2717.1 3572.4 3242.0 2455.2 False True 1745.1325018692562 2239.5254008131424 2356.7747988880315 2079.3515481179948 2812.147235901624 3346.693227430005 2512.146959450241 3477.6483472094046 5501.437213688531 2770.348835673209 0.6299324039621097 0.8083911209935863 0.8507140936694794 0.7505739065574034 1.0150877751170486 1.2080403681786671 0.9067980635152671 1.2553106317978608 1.9858283342688334 1.0 11.43585193306999 -7.051879005193124 0.7824017485923052 1.4286437594756938 0.7463867449687649 0.47010569321167084 0.26552636068956836 0.5828390929663446 0.7358562774895892 0.20282290406017078 0.14788246080824255 8.874032088799468e-08 7.051879005193124 -0.6822570145069289 EVESRLS(ph)PGESAYQK ddPTM_A459_Selumetinib_30min_R1 2 EVESRLSPGESAYQK 15 1 A0A0G2JHC2;Q6NYC8;Q6NYC8-2 A0A0G2JHC2 PPP1R18 Phostensin 1 EVES(0.005)RLS(0.995)PGESAYQK;EVES(0.101)RLS(0.899)PGES(0.001)AYQK 196.22 0.00015261 11344400.0 2234.3999999999996 1912.26 3255.3 3656.6 3008.3 2075.5 2089.1 2162.6 1333.88 1575.75 True False 2286.4571726144404 1688.371710214445 2813.248140082948 3018.0434528830465 2736.1997961585016 2054.6223544032214 1931.5175050559403 2105.24082288519 2263.4969372593655 1778.0128616047823 1.285962110842523 0.9495835191487706 1.5822428514627238 1.6974249838435076 1.538908888256797 1.1555722676543405 1.086334945469747 1.1840413915707344 1.2730486860575347 1.0 10.796050044885071 -6.782659053465983 23.437943009719966 1.147960225939767 1.410645406203764 0.3148113035251612 0.19973997120500772 172.79438312713083 190855.64854143528 0.07875830616311254 0.06954741251608706 1.649456803294579e-07 6.782659053465983 0.2626851802639971 EVFEDAAEIR ddPTM_A459_Selumetinib_30min_R1 4 EVFEDAAEIR 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 ;;; 160.82 0.0060348 53423600.0 13779.3 16100.3 16431.5 17237.199999999997 16030.900000000001 15061.6 15727.7 14685.6 10291.2 13356.6 False True 14100.330880149548 14215.269391173599 14200.192551768783 14227.0466023179 14580.907925485271 14910.093978838633 14541.346926556093 14296.090182448326 17463.414760490887 15071.049714301402 0.9355904961795257 0.9432169398050804 0.942216555645342 0.9439983857804808 0.9674779263483538 0.9893202040658102 0.9648529599605357 0.9485795915650327 1.1587391118429722 1.0 13.879492285196227 -8.23804116768706 24.91761026095911 1.079369557162248 0.9552280630800359 0.6267929112548585 0.038566224156004775 380.8894216146168 405624.2421664129 0.02425954410709101 0.009159102980150812 5.780412510630876e-09 8.23804116768706 -0.12414149408221198 EVFEDAAEIR ddPTM_A459_Selumetinib_30min_R2 3 EVFEDAAEIR 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 ;; 152.28 0.008862700000000001 52852000.0 122130.0 117922.0 133124.0 137179.0 132481.0 100910.0 96593.0 121752.0 102478.0 119204.0 False True 115342.50352512639 126966.23822100807 124558.94677445227 118494.98355302551 115837.55238483292 114809.43653022441 101084.76589539844 122106.27816287123 122976.46347455804 115762.2707908128 0.9963738853529839 1.096784274821641 1.075989145025804 1.0236062470401157 1.0006503120015342 0.9917690431080934 0.8732099431434165 1.054802029441201 1.0623190322240792 1.0 16.82080560157901 -6.033500285891224 2.9646615014738993 0.9934316247343777 1.0600521396995863 0.19205531243233154 0.053678123548594095 0.41801741421214017 7.390247788362719 0.017281453385871698 0.024997269784953476 9.257627757012934e-07 6.033500285891224 0.0666205149652086 EVFEFRPELVNDDDEEADDTR ddPTM_A459_Selumetinib_30min_R1 1 EVFEFRPELVNDDDEEADDTR 21 1 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 206.63 3.8143e-17 6933700.0 1756.7 2330.4 2316.0 2740.6 2599.8 2549.6 2397.8 2561.7 1371.5 2363.8 False True 1797.6276920568334 2057.5556846264317 2001.4999208773697 2262.005657433483 2364.6485490319687 2523.9533388515806 2216.932015520146 2493.755394425688 2327.335329603276 2667.2167553618183 0.6739713555124912 0.7714242498252889 0.7504076737872242 0.8480771774120898 0.8865603233327001 0.9462872988397962 0.8311780477021675 0.9349654051972242 0.8725707518613589 1.0 11.38111935708701 -3.0613946374517194 0.28398959344253827 0.9530874317759309 7.29677254426589e-16 0.7894257289204423 0.04310807524666447 10.074583595451424 0.30652261915518336 0.0483999667567612 4.011354990461509 0.0008681711754836378 3.0613946374517194 -0.9530874317759301 EVFEFRPELVNDDDEEADDTR ddPTM_A459_Selumetinib_30min_R2 4 EVFEFRPELVNDDDEEADDTR 21 1 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 ;;; 193.72 4.8877e-16 23005200.0 55294.3 55488.4 62620.8 65923.0 71396.0 48065.0 57996.6 61306.2 64707.0 68438.0 False True 52221.264166620815 59744.18185667282 58591.845904371876 56944.17367648196 62426.59619166178 54685.51745937204 60693.556818082674 61484.590892212225 77650.20806464044 66462.01711672124 0.7857309547934623 0.8989221881687627 0.8815839248675271 0.8567927388733334 0.9392822983694219 0.8228085729527709 0.9132066622578136 0.9251087095992345 1.168339623642033 1.0 16.020242458918993 -8.091750496446162 4.569449703808644 1.0820246734210053 0.8752360739800029 0.6877420267085239 0.05640825434840121 0.11907490089719083 4.152501929638691 0.0380175347337894 0.013664477684679979 8.095608608804067e-09 8.091750496446162 -0.20678859944100236 EVFSSCSSEVVLS(ph)GDDEEYQR ddPTM_A459_Selumetinib_30min_R1 1 EVFSSCSSEVVLSGDDEEYQR 21 0 Q09666;E9PKR9;E9PLK4 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 EVFSSCSSEVVLS(1)GDDEEYQR 117.51 5.0159e-05 5112600.0 467.26 406.91 406.74 545.2 465.36 326.33 541.78 499.37 302.53 284.54 True False 478.14624887031135 359.2687880326734 351.5069420628938 449.99105467150815 423.2682701659809 323.0474164839334 500.91309841041937 486.12508541763526 513.3713140830328 321.06348065430757 1.4892576629888856 1.1189961165950912 1.0948206919907064 1.4015641198259428 1.318332029863335 1.0061792634452933 1.5601684046705946 1.514108937045541 1.5989713717574285 1.0 8.32671476491249 -7.28506468763092 24.93239097673466 1.4611545884035895 1.2373255386582258 0.14116900931586696 0.20712537790001265 1218.5298823305247 1285939.890936693 0.0833034298628938 0.056198285466420535 5.187227700535649e-08 7.28506468763092 -0.22382904974536366 EVGGGHGCTS(ph)PPFPQEAR ddPTM_A459_Selumetinib_30min_R1 2 EVGGGHGCTSPPFPQEAR 18 0 A0A1B0GVD3;Q6ZN17-2;Q6ZN17 A0A1B0GVD3 LIN28B Protein lin-28 homolog B 1 EVGGGHGCT(0.196)S(0.804)PPFPQEAR;EVGGGHGCT(0.183)S(0.817)PPFPQEAR 100.28 0.0018681 8983400.0 3365.3999999999996 4020.7000000000003 4352.0 5014.4 4443.9 3246.4 3605.5 3496.2 1923.03 3084.9 True False 3443.807272071534 3549.954574827282 3761.022303824834 4138.72917194573 4041.95002963427 3213.744163495358 3333.534232195296 3403.469418741888 3263.2414574458567 3480.8769644706304 0.9893504732349154 1.0198448870964782 1.0804812529180583 1.1889903648390356 1.1611872728885628 0.9232570401936347 0.9576708014160615 0.977762056367162 0.9374768171221841 1.0 11.765235105938547 -6.771565790185877 24.999920408011366 0.9577457991755207 1.0893821847857297 0.5507140423684064 0.05812501596953375 179.65764602790026 443533.1443336213 0.022976249540848915 0.02048806233765023 1.6921318881879725e-07 6.771565790185877 0.13163638561020896 EVGS(ph)IIGK ddPTM_A459_Selumetinib_30min_R1 2 EVGSIIGK 8 0 Q15365;H3BSP4;C9K0A2;F8WC71;F8VTZ0;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;H3BRU6;F8VZX2;F8W0G4;J3QT27;E9PFP8;P57721-2;P57721-3;P57721-5;P57721-4;P57721;F8W1G6;Q15366;Q15366-2;Q15366-6;Q15366-3;Q15366-5;Q15366-8;Q15366-4;Q15366-7 Q15365;H3BRU6;Q15366;Q15366-5 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 3;Poly(rC)-binding protein 2 1 EVGS(1)IIGK;EVGS(1)IIGK 101.97 0.016599000000000003 8388500.0 4428.2 5428.1 6825.5 6684.6 7096.700000000001 5871.299999999999 7214.3 7528.4 3361.7 5808.8 True False 4531.368444222728 4792.575528544772 5898.634589787775 5517.26009548269 6454.804738024152 5812.240052713871 6670.11954273375 7328.7223763103975 5704.559371146438 6554.416062503484 0.6913458652931401 0.7311979408756407 0.8999481469497634 0.8417622627049636 0.9848024105382647 0.8867670281056073 1.017652751843476 1.1181350567957635 0.8703383057693106 1.0 12.678251540127233 -4.760689662846852 0.5031222889053695 1.0065882351283915 0.43563760654897465 0.6817252819193952 0.07021852760814366 2.5572164790952967 0.49022595899381494 0.04353750003024395 0.873449166390468 1.735043378195758e-05 4.760689662846852 -0.5709506285794168 EVGS(ph)IIGK ddPTM_A459_Selumetinib_30min_R2 2 EVGSIIGK 8 0 Q15365;H3BSP4;C9K0A2;F8WC71;F8VTZ0;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;H3BRU6;F8VZX2;F8W0G4;J3QT27;E9PFP8;P57721-2;P57721-3;P57721-5;P57721-4;P57721;F8W1G6;Q15366;Q15366-2;Q15366-6;Q15366-3;Q15366-5;Q15366-8;Q15366-4;Q15366-7 Q15365;H3BRU6;Q15366;Q15366-5 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 3;Poly(rC)-binding protein 2 1 EVGS(1)IIGK;EVGS(1)IIGK 104.42 0.014616999999999996 5204900.0 38658.0 37151.0 42254.0 42729.0 41555.0 32047.0 38709.0 39826.0 29838.0 36019.0 True False 36509.54312023531 40000.362240707065 39535.42364267672 36909.23648836368 36334.4893935865 36461.18335629868 40509.04520042835 39941.88706645077 35806.43374337774 34979.03788139898 1.0437549267085533 1.1435523863273067 1.1302604656173436 1.0551815808516314 1.0387503943585685 1.0423723911425211 1.1580948949419245 1.1418806658398948 1.0236540485985965 1.0 15.094202987195986 -8.437836061880697 5.886881053256905 1.0004103353498028 1.0941314486850253 0.35796279688556876 0.04465921211802825 0.23982715313410818 12.095218710379303 0.04632148093360032 0.012013579524763372 3.6489166077214245e-09 8.437836061880697 0.09372111333522248 EVGS(ph)PPLDPTER ddPTM_A459_Selumetinib_30min_R1 2 EVGSPPLDPTER 12 0 A0A1B0GV79;A0A1B0GW21;A0A1B0GTE6;A0A0D9SFK7;A0A1B0GUH6;A0A1B0GUA3;Q96EK5 A0A1B0GV79 KIF1BP;KIAA1279 KIF1-binding protein 1 EVGS(1)PPLDPTER;EVGS(1)PPLDPTER 113.07 0.0061121000000000005 20763500.0 6421.4 6164.1 7395.9 8042.0 7392.3 5895.700000000001 6730.9 6789.9 3466.6 5679.8 True False 6571.00612613067 5442.404306387656 6391.577402770702 6637.615667036444 6723.667770216565 5836.394610867299 6223.182793921317 6609.809795296476 5882.567009553571 6408.8576559370695 1.0253006821025878 0.8492003721358821 0.9973036921563768 1.035694038373197 1.0491210963295245 0.9106762740253016 0.9710283997579903 1.0313553756609413 0.9178807402757727 1.0 12.645851511867383 EVGS(ph)PPLDPTER ddPTM_A459_Selumetinib_30min_R2 1 EVGSPPLDPTER 12 0 A0A1B0GV79;A0A1B0GW21;A0A1B0GTE6;A0A0D9SFK7;A0A1B0GUH6;A0A1B0GUA3;Q96EK5 A0A1B0GV79 KIF1BP;KIAA1279 KIF1-binding protein 1 EVGS(1)PPLDPTER 133.88 0.0016794 10480000.0 38997.0 35711.0 32246.0 42688.0 46127.0 33098.0 31729.0 34673.0 31792.0 35070.0 True False 36829.70285735983 38449.918871036876 30171.327466790193 36873.820759092596 40332.11387938793 37656.94906627058 33204.46136982074 34773.892689575834 38151.28834269939 34057.43797719712 1.0813996896072704 1.1289727341434403 0.8858953949205209 1.0826950865705507 1.1842380482757384 1.1056894265353572 0.9749547629522959 1.0210366590950972 1.1202042962903807 1.0 15.055682289709308 -11.011525945067678 3.203195997567502 0.9985523706329708 1.06290412963726 0.05413993759482938 0.08108927622751015 62302439.931016535 71165382.95105775 783279.2613760624 0.02107743316249836 9.738096074978495e-12 11.011525945067678 0.06435175900428936 EVGTVLSQVYS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 EVGTVLSQVYSK 12 0 P04114 P04114 APOB Apolipoprotein B-100;Apolipoprotein B-48 1 EVGT(0.029)VLS(0.146)QVY(0.332)S(0.493)K 87.258 0.028765 2244700.0 1395.6 1521.9 1403.9 1641.5 2769.5 1735.4 2818.1 2009.6 746.94 1041.1 True False 1428.1147646351212 1343.715240487886 1213.2580910707004 1354.842839771242 2518.999213994938 1717.9434516171286 2605.5284481346735 1956.2988798992315 1267.5026256608612 1174.7353261727674 1.2156906605404063 1.1438450947633005 1.0327927185295758 1.1533175257317378 2.144312133867396 1.4624089472256767 2.2179706271568107 1.6653103352844265 1.0789686812180284 1.0 10.19812003155413 -6.094792580782529 13.255049901429459 1.6525780947508044 1.1255856897589689 0.26134764003837874 0.37010098299099764 1.3392337368850045 184.01455825082283 0.10675352489997593 0.13784131855275236 8.039099782391024e-07 6.094792580782529 -0.5269924049918355 EVHDELEDLPSPPPPLS(ph)PPPTTSPHK ddPTM_A459_Selumetinib_30min_R1 2 EVHDELEDLPSPPPPLSPPPTTSPHK 26 0 H0YJ30;G3V582;F5H039;Q9NQX3;Q9NQX3-2 H0YJ30 GPHN Gephyrin;Molybdopterin adenylyltransferase;Molybdopterin molybdenumtransferase 1 EVHDELEDLPS(0.002)PPPPLS(0.967)PPPT(0.023)T(0.005)S(0.002)PHK;EVHDELEDLPSPPPPLS(0.988)PPPT(0.008)T(0.003)S(0.001)PHK 124.39 3.9958e-09 20522300.0 5787.5 5991.2 5036.6 5791.5 6907.3 4958.5 7085.900000000001 5464.6 2145.26 4958.9 True False 5922.337489485355 5289.747518766687 4352.657384063455 4780.123244919367 6282.535934582862 4908.621991957783 6551.404858109185 5319.661056477581 3640.3495364088403 5595.423118776426 1.0584253172225546 0.9453704226613371 0.7778960217427253 0.8542916493444119 1.1227990808238806 0.8772566234510557 1.1708506611635487 0.9507164951702264 0.6505941479551398 1.0 12.450031514752023 -11.852522012920492 3.1488652514348314 1.6664939837260284 0.9389347709615005 0.016358116386446686 0.14902742278186612 0.34763283834703407 0.03639243590156523 0.07193745412464177 0.03517833557426416 1.4043584995846926e-12 11.852522012920492 -0.727559212764528 EVHDELEDLPSPPPPLS(ph)PPPTTSPHK ddPTM_A459_Selumetinib_30min_R2 3 EVHDELEDLPSPPPPLSPPPTTSPHK 26 0 H0YJ30;G3V582;F5H039;Q9NQX3;Q9NQX3-2 H0YJ30 GPHN Gephyrin;Molybdopterin adenylyltransferase;Molybdopterin molybdenumtransferase 1 EVHDELEDLPSPPPPLS(0.896)PPPT(0.043)T(0.043)S(0.017)PHK;EVHDELEDLPSPPPPLS(0.948)PPPT(0.016)T(0.016)S(0.02)PHK;EVHDELEDLPSPPPPLS(1)PPPTTSPHK 132.65 2.7941e-09 17890100.0 65195.0 50442.4 78732.0 92284.0 101853.0 62826.0 62369.0 73453.0 75325.0 75529.0 True False 61571.72289626317 54311.16988212005 73666.46883692007 79714.76000122065 89057.31556262702 71479.71122235527 65269.282081828926 73666.73606920116 90392.10475634872 73348.28152209055 0.839443291902066 0.740455928279151 1.004338033669319 1.0867979228281264 1.2141704442769437 0.9745246887730762 0.8898542778016082 1.004341677003226 1.2323684056473092 1.0 16.16247554492186 -5.358279213819665 4.607755277925465 1.0529109312867906 0.7908604809576424 0.5178150470740258 0.10142439729005555 0.17669895759999293 6.201044289385307 0.02858649804474356 0.06293656337612626 4.382488510458667e-06 5.358279213819665 -0.2620504503291482 EVIEIEDAS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 EVIEIEDASPTK 12 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 EVIEIEDAS(0.974)PT(0.026)K;EVIEIEDAS(0.992)PT(0.008)K 193.11 0.00015352 19505000.0 5713.6 8020.1 4252.4 4317.7 4734.2 5288.9 6566.0 5636.8 3476.8 6853.8 True False 5846.715763269723 7081.102963556661 3674.9474367611956 3563.694748267006 4305.992445890898 5235.698467936978 6070.7213336830755 5487.2937530931495 5899.875664575046 7733.551991665469 0.756019455170249 0.9156339766239421 0.4751952842266691 0.4608095674675282 0.5567936247834775 0.6770108319669339 0.7849848737327371 0.7095437851852375 0.7628933859801298 1.0 12.916915475495593 -8.733495786512265 0.7085629429839158 0.999409020937205 0.6413049719867572 0.38918492593404364 0.1304769159992679 1.1741084188567157 1.2307313137487002 0.14913830046146703 0.05562757385320622 1.847158715797766e-09 8.733495786512265 -0.3581040489504478 EVIEIEDAS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 EVIEIEDASPTK 12 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 EVIEIEDAS(0.998)PT(0.002)K;EVIEIEDAS(0.992)PT(0.008)K 177.36 0.00010365 19103400.0 75171.0 51451.0 62384.0 74376.0 71160.0 63109.0 95038.0 88881.0 69046.0 54655.0 True False 70993.29675335529 55397.126258959936 58370.28135856352 64245.860494243534 62220.24462152852 71801.69190353708 99457.45531422437 89139.62899495834 82857.1293064299 53076.96813925603 1.3375537307838095 1.04371308688199 1.099729004969154 1.2104282280345047 1.1722644831235203 1.3527843511173 1.873834523729419 1.6794408595661696 1.5610750238981395 1.0 15.695798343034783 -7.000287147300816 4.940233968520811 1.5906004630782802 1.169223613494202 0.3511509270417006 0.2213039201167495 0.1671505874549115 11.700326807273845 0.07900078464838092 0.06553077469800983 9.993390374377013e-08 7.000287147300816 -0.4213768495840782 EVIEIEDAS(ph)PTKCPITTK ddPTM_A459_Selumetinib_30min_R1 2 EVIEIEDASPTKCPITTK 18 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 EVIEIEDAS(0.993)PT(0.007)KCPITTK;EVIEIEDAS(0.877)PT(0.115)KCPIT(0.006)T(0.002)K 107.06 0.00088924 89929000.0 5925.3 6455.8 7022.9 7262.799999999999 6259.3 5293.8 6068.1 5267.8 3898.6 5261.4 True False 6063.347961373228 5699.951934780007 6069.228754028362 5994.488319640919 5693.147420169171 5240.549178385826 5610.378331544664 5128.08083177407 6615.639457521941 5936.751940375945 1.0213241217198754 0.9601128684549782 1.0223146958105898 1.0097252470449891 0.9589667005370367 0.8827300232547645 0.945024886990543 0.8637855991418322 1.1143533575201063 1.0 12.53545811785187 -6.334626064952464 5.460043190296401 0.9487459364455437 1.001556744529403 0.07357168175077633 0.06655549050725228 0.4819234083209135 26.314035465447212 0.020212151244964498 0.023092947883850422 4.627793108847063e-07 6.334626064952464 0.052810808083859184 EVIEIEDAS(ph)PTKCPITTK ddPTM_A459_Selumetinib_30min_R2 4 EVIEIEDASPTKCPITTK 18 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 EVIEIEDAS(0.959)PT(0.04)KCPITTK;EVIEIEDAS(0.596)PT(0.397)KCPIT(0.006)T(0.001)K;EVIEIEDAS(0.871)PT(0.12)KCPIT(0.006)T(0.002)K;EVIEIEDAS(0.995)PT(0.004)KCPITTK 90.882 0.003068 157053000.0 274226.0 212076.0 257586.0 258969.0 266315.0 210764.0 234662.0 240484.0 177185.0 236397.0 True False 258985.61673365536 228341.54726818085 241013.19719843182 223696.9754535573 232858.12881369246 239794.82787490016 245574.2479739317 241183.76862573085 212626.9509625437 229571.60437683124 1.1281256557694408 0.9946419457581029 1.049838885138511 0.9744104723263989 1.0143159013318848 1.0445317421804832 1.0697065459839399 1.0505818839417038 0.9261901163243443 1.0 17.80858468109252 -4.753955465838718 24.998296899548908 1.0180011834962435 1.1281258509987586 0.41048711809913296 0.040822983762905864 283.92238943919824 948298.6074260458 0.010139551257513396 0.10345779807684488 1.7621567352115998e-05 4.753955465838718 0.11012466750251515 EVIEIEDASPT(ph)KCPITTK ddPTM_A459_Selumetinib_30min_R1 2 EVIEIEDASPTKCPITTK 18 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 EVIEIEDAS(0.067)PT(0.932)KCPIT(0.001)TK;EVIEIEDAS(0.234)PT(0.761)KCPIT(0.004)T(0.001)K 87.963 0.0092485 119461000.0 5526.0 6099.299999999999 6780.3 7228.1 5571.7 5002.3 6077.9 5917.299999999999 3345.6 4885.3 True False 5654.745048275783 5385.191120512358 5859.572501521948 5965.848023241251 5067.740718763531 4951.981403724999 5619.439109654636 5760.353981900736 5677.238847043913 5512.375841851716 1.0258271951166962 0.9769274220430089 1.0629849396396747 1.0822643800784826 0.919338750505295 0.8983388552950211 1.019422345441336 1.0449857098215782 1.0299077947371629 1.0 12.42845854111691 -13.363007333661908 15.713715093333455 1.0271557455698381 1.0051181828004456 0.0 0.05631905956861189 0.0 0.0 0.0 0.01404565897495081 4.335035580196551e-14 13.363007333661908 -0.022037562769392505 EVIGGLCSLANIPLT(ph)PETQR ddPTM_A459_Selumetinib_30min_R2 1 EVIGGLCSLANIPLTPETQR 20 0 Q01664 Q01664 TFAP4 Transcription factor AP-4 1 EVIGGLCSLANIPLT(1)PETQR 199.36 1.7672e-23 0.0 7471.3 6133.3 6911.0 7130.9 6937.0 5089.3 7001.0 7382.5 5630.0 7452.6 True False 7056.0750559836015 6603.70438833218 6466.353784127865 6159.659118511372 6065.512042433148 5790.304878934403 7326.560372218322 7403.981852761332 6756.157315343405 7237.424073819768 0.9749428780203487 0.9124385031160509 0.8934606730478697 0.8510844543147555 0.8380760862658545 0.8000505179570604 1.0123160253550696 1.023013406046505 0.9335030318014294 1.0 12.821260592855738 -7.280942424665705 24.955935481242477 0.9941259111012424 0.8775099548044597 0.5634332973997918 0.04908759164249212 657.2221820096789 840972.5297348312 0.022163072951699163 0.014967532557729733 5.2366985600001546e-08 7.280942424665705 -0.11661595629678267 EVLDEDT(ph)DEEKETLK ddPTM_A459_Selumetinib_30min_R1 1 EVLDEDTDEEKETLK 15 1 Q9Y3P9 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 EVLDEDT(1)DEEKETLK 101.05 0.0099537 40470000.0 2445.3 2818.0 2903.2 2814.9 1861.8 2122.5 2441.9 2794.3 1759.2 2281.0 True False 2502.2707322744773 2488.0672499473408 2508.9613861360885 2323.3305572172208 1693.4005187274881 2101.1495770758065 2257.70551701503 2720.186086834409 2985.2339131156286 2573.78856882152 0.9722130102630033 0.9666944985642588 0.9748125454162249 0.9026889719542975 0.6579408033904114 0.8163644840640021 0.8771915239520948 1.056880164822521 1.1598598071645412 1.0 11.329677828803007 -7.7962720269424075 4.875149354999883 1.0870192221155779 0.8772287533536304 0.4542203972644363 0.09595982522305324 0.19037061850034062 10.609533753804376 0.05972000371610514 0.028836051887722185 1.598556434872658e-08 7.7962720269424075 -0.2097904687619475 EVLDEDT(ph)DEEKETLK ddPTM_A459_Selumetinib_30min_R2 4 EVLDEDTDEEKETLK 15 1 Q9Y3P9 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 EVLDEDT(1)DEEKETLK;EVLDEDT(1)DEEKETLK;EVLDEDT(0.994)DEEKET(0.006)LK;EVLDEDT(0.997)DEEKET(0.003)LK 134.76 0.00058644 130927000.0 202396.0 163558.0 170333.0 155108.0 144644.0 117431.0 159091.0 154710.0 86106.0 146556.0 True False 191147.6405753827 176102.3726781396 159373.9602245484 133982.02282377568 126472.52758623331 133606.05431751817 166489.04673283588 155160.18048638073 103329.60600265693 142324.54748178215 1.3430405643822618 1.2373295808348246 1.1197924957038674 0.9413837963610997 0.8886206197312664 0.9387421683853941 1.1697844797584678 1.090185658283871 0.726013943700635 1.0 17.118824987151456 -5.350066347100107 1.9570121492956338 0.9733580869152254 1.3241048161607045 0.5721676107325355 0.11315586882197928 0.28722753943749535 2.0303627801033626 0.03393419078171872 0.11684553995139417 4.466153575806455e-06 5.350066347100107 0.3507467292454791 EVLHGNQR ddPTM_A459_Selumetinib_30min_R2 1 EVLHGNQR 8 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 86.794 0.04689 1020400.0 1081.9 1033.9 2151.8 1063.9 1952.7 2437.0 4268.7 14135.0 3771.9 5591.9 False True 1021.7723291888509 1113.1968054875256 2013.3555307026975 918.9949846701328 1707.3843686405094 2772.674629116607 4467.203008268581 14176.130509824774 4526.385395691618 5430.447317498961 0.18815619956321333 0.2049917327989507 0.3707531650689074 0.16923007092045297 0.31440952629052665 0.5105794176811177 0.8226215534535356 2.6104903852292067 0.8335198062056303 1.0 12.406855325446346 -7.5299035098518745 24.996853765607494 1.5765145298476924 0.31945600633355137 0.5786132492877629 0.452284290758397 110.5564618161194 393396.1044295536 0.1996205536518727 0.11557428312397049 2.9518649896646746e-08 7.5299035098518745 -1.257058523514141 EVLRDDCS(ph)DGETREENK ddPTM_A459_Selumetinib_30min_R2 1 EVLRDDCSDGETREENK 17 2 C9JUB9;C9IYG2;C9JS03;Q8N720-3 C9JUB9 ZNF655 1 EVLRDDCS(0.926)DGET(0.074)REENK 65.808 0.048146 4020300.0 16704.0 13110.0 14528.0 12709.0 12167.0 14079.0 11691.0 13888.0 10960.0 12753.0 True False 15775.658551410073 14115.494844705927 13593.284296890399 10978.012275752146 10638.472685639921 16018.254453562857 12234.654665277008 13928.411780717825 13152.306247986455 12384.787753726689 1.2737932102762959 1.139744590330864 1.0975791081118902 0.8864110143872888 0.8589951557658881 1.2933814266411492 0.9878776212047313 1.1246387146624008 1.0619726804788248 1.0 13.596281523929465 -4.9461291002275205 1.986029559124228 1.0379698437275309 1.2971611324991108 0.2892420276906962 0.11618342688229323 0.7251199205437181 4.067801637940955 0.03290055771852044 0.30763014759270074 1.1320637911081565e-05 4.9461291002275205 0.25919128877157993 EVLS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 EVLSPLK 7 0 Q8WVV4-3;Q8WVV4;Q8WVV4-1 Q8WVV4-3 POF1B Protein POF1B 1 EVLS(1)PLK 81.97200000000002 0.04203 3563700.0 2530.8 3177.6 3202.0 3376.9 2761.7 2422.0 3139.7 3141.8 2027.4 2818.5 True False 2589.7627159204376 2805.565114773838 2767.1859873270037 2787.1878072637846 2511.904722617736 2397.6368790000506 2902.8699012130287 3058.4692579953244 3440.349724562659 3180.281929514886 0.814318596060908 0.8821749696894934 0.8701071315866341 0.876396454476895 0.7898371208243468 0.7539070221254822 0.9127712465592089 0.9616975242386316 1.0817750755472937 1.0 11.634938949632081 -7.767637918582661 2.3138519460894384 1.034625597637477 0.8359803009933103 0.7694565298769468 0.045367276432225045 0.15018268550014963 1.5955368534731207 0.03217840678072203 0.01372556055536576 1.7075053827072804e-08 7.767637918582661 -0.19864529664416664 EVLS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 4 EVLSPLK 7 0 Q8WVV4-3;Q8WVV4;Q8WVV4-1 Q8WVV4-3 POF1B Protein POF1B 1 EVLS(1)PLK;EVLS(1)PLK;EVLS(1)PLK;EVLS(1)PLK 116.37 0.012368 20528400.0 168607.0 127372.0 152207.0 150148.0 144735.0 114744.0 121348.0 137314.0 102036.0 151772.0 True False 159236.49792729874 137141.02283446843 142414.1673304511 129697.583380253 126552.09535268294 130548.94445767565 126990.92244650018 137713.56100644352 122446.051124046 147389.94800898686 1.0803755620945708 0.930463879572754 0.9662407053822126 0.8799622032049628 0.8586209376026555 0.8857384524602427 0.861598257967749 0.9343483925921913 0.8307625640561326 1.0 17.169278610456693 -1.5228828733266169 0.8562157909720803 0.8895855860175994 70.2347524018182 0.5481473472327835 0.048665237377991326 472.38907463790497 1.275035613666313 0.015464387546127438 63835.90207091795 0.029999714846020445 1.5228828733266169 69.3451668158006 EVLT(ph)PTSTSDNETR ddPTM_A459_Selumetinib_30min_R2 1 EVLTPTSTSDNETR 14 0 Q70CQ2-3;Q70CQ2-2;Q70CQ2;H7C150;H7C183 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 EVLT(0.861)PT(0.059)S(0.059)T(0.017)S(0.005)DNETR 104.9 0.014056 7457000.0 31953.0 24154.0 31887.0 27739.0 35187.0 23402.0 22465.0 24907.0 20398.0 28677.0 True False 30177.18017799367 26006.534132648903 29835.425135940546 23960.90034755598 30766.49448422881 26625.413077795158 23509.66701355299 24979.475246424186 24478.16996773975 27849.020498205904 1.083599338078614 0.9338401734568834 1.071327630279227 0.8603857485436371 1.1047603805746367 0.9560628202169776 0.8441829045681349 0.8969606398915689 0.8789598172516224 1.0 14.765338965741986 -7.003498330594601 24.93563964263263 0.8969654515196208 1.0044058296072635 0.28855859227609404 0.07763297559566211 169.43048539776518 1207686.999953718 0.02582232781743205 0.022314577032208065 9.919771523403295e-08 7.003498330594601 0.10744037808764273 EVLTPTSTS(ph)DNETR ddPTM_A459_Selumetinib_30min_R1 2 EVLTPTSTSDNETR 14 0 Q70CQ2-3;Q70CQ2-2;Q70CQ2;H7C150;H7C183 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 EVLT(0.088)PT(0.026)S(0.026)T(0.164)S(0.695)DNETR;EVLT(0.075)PT(0.031)S(0.031)T(0.181)S(0.682)DNETR 151.07 0.00040885 16743200.0 6145.9 5916.6 6898.3 6113.5 6362.9 5283.2 5717.1 5182.1 2764.0 4044.8999999999996 True False 6289.087512160357 5223.8817214472865 5961.548749649557 5045.8919896079715 5787.3768184612345 5230.055804761796 5285.854544136381 5044.6538741669065 4690.30612542724 4564.102315662497 1.3779462153112296 1.1445584170014427 1.3061821005176601 1.105560664644202 1.2680208326182483 1.145911165666459 1.1581367328241237 1.1052893921451574 1.0276513980266508 1.0 12.156115418235297 -2.8321815739307357 0.1069890701045939 0.8801782056233011 1.9138219665069052 0.619407605822004 0.07031218925641981 55.9751702856652 0.5673865469946833 0.7704336450915095 8.407686657847677 0.0014716970728046817 2.8321815739307357 1.0336437608836042 EVLTPTSTS(ph)DNETR ddPTM_A459_Selumetinib_30min_R2 1 EVLTPTSTSDNETR 14 0 Q70CQ2-3;Q70CQ2-2;Q70CQ2;H7C150;H7C183 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 EVLTPT(0.046)S(0.046)T(0.214)S(0.694)DNETR 115.09 0.0028476 8621700.0 47956.0 37996.0 49012.0 51084.0 57789.0 39151.0 37724.0 34472.0 36630.0 39027.0 True False 45290.797503078385 40910.17102360385 45858.62128023076 44126.27107518476 50529.02917978512 44543.69487260737 39478.24074868787 34572.30781285321 43957.02352771384 37900.1891056764 1.195001887109188 1.0794186516994617 1.2099839700631574 1.1642757494467453 1.3332131150822482 1.175289515004978 1.0416370387654643 0.9121935438489733 1.1598101372304312 1.0 15.209917426392806 -7.267235132774156 4.644030077179864 1.0189540032006787 1.1945242083506804 0.49863873931606373 0.08093503015498363 0.16496219648189045 9.965791730774999 0.033790411169876106 0.023804644363603574 5.4046163064690694e-08 7.267235132774156 0.17557020515000166 EVLYDS(ph)EGLSGEER ddPTM_A459_Selumetinib_30min_R2 2 EVLYDSEGLSGEER 14 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 EVLYDS(0.973)EGLS(0.027)GEER;EVLYDS(0.999)EGLS(0.001)GEER 166.79 0.00022640000000000005 13910000.0 29245.0 25718.0 29443.0 32799.0 36540.0 25954.0 27650.0 29560.0 24413.0 34046.0 True False 27619.679977010746 27690.48790359627 27548.66943511455 28331.719618569106 31949.518528255336 29528.927913045685 28935.779787435575 29646.01470607855 29296.2821562129 33063.00351786864 0.8353651222909592 0.8375067282871371 0.833217388136746 0.8569009649488575 0.9663223279454473 0.8931108723104061 0.8751709375646245 0.8966521958616553 0.8860744348401366 1.0 15.012930167806758 -12.876993347981236 0.018181679622296106 2.0227001811961087 1.846188507666338e-06 0.6201626728320286 0.032749141222468296 2172.7098887709026 3.978825883822489 271.31690647286723 179.57311318036048 1.3274147893729716e-13 12.876993347981236 -2.022698335007601 EVMESAVGNSSGSGQNEES(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 EVMESAVGNSSGSGQNEESPR 21 0 Q9NVF7 Q9NVF7 FBXO28 F-box only protein 28 1 EVMESAVGNSSGS(0.001)GQNEES(0.999)PR;EVMESAVGNSSGSGQNEES(1)PR;EVMESAVGNS(0.001)S(0.001)GS(0.013)GQNEES(0.984)PR 277.8 9.273099999999999e-73 42602900.0 7540.14 8483.26 8535.79 9012.49 7900.21 8573.96 8039.639999999999 7783.87 4248.8 6711.66 True False 7715.81059144157 7490.035975439417 7376.676601738283 7438.627806889985 7185.637400395359 8487.713746932814 7433.203482048704 7577.416482026886 7209.90327992592 7573.166938104619 1.0188354032735283 0.989022959173536 0.9740544031351418 0.9822347596039781 0.9488286022378045 1.1207614748628643 0.9815185037911044 1.0005611316846703 0.9520327940546344 1.0 12.886681015579976 -4.751080831877115 23.74636268121354 0.9954688365308231 1.0188354969735802 0.024931222455219504 0.04547151813108453 1243.280297475639 2849773.1357637886 0.011359914132434598 0.14521023939577607 1.7738592954355865e-05 4.751080831877115 0.023366660442757148 EVMESAVGNSSGSGQNEES(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 EVMESAVGNSSGSGQNEESPR 21 0 Q9NVF7 Q9NVF7 FBXO28 F-box only protein 28 1 EVMESAVGNSSGSGQNEES(1)PR;EVMESAVGNSSGS(0.001)GQNEES(0.998)PR;EVMESAVGNSSGSGQNEES(1)PR;EVMESAVGNSSGSGQNEES(1)PR 288.37 1.701799999999999e-153 47471000.0 128287.0 130125.8 144144.8 148634.0 168902.0 133821.0 119176.6 127878.0 123297.6 135392.9 True False 121157.32211355018 140106.03043960605 134870.68050099188 128389.79279204873 147683.02075696184 152253.62804391186 124718.54804395283 128250.10380865751 147960.5652227863 131483.75518399928 0.921462289725463 1.0655767341261337 1.0257592682248307 0.9764688619699001 1.123203551269837 1.1579653154174603 0.9485472016632079 0.9754064570880518 1.125314416337815 1.0 17.004525040013682 -4.755185812652964 24.96997181428156 1.0438148794916244 0.9214620840872868 0.22405648414382762 0.06854598288080362 340.6865227503512 1360201.2938752852 0.017599021177545096 0.159882612663637 1.757171648191992e-05 4.755185812652964 -0.12235279540433763 EVMS(ph)PLQAMSSYTVAGR ddPTM_A459_Selumetinib_30min_R1 2 EVMSPLQAMSSYTVAGR 17 0 Q9BYT8 Q9BYT8 NLN Neurolysin, mitochondrial 1 EVMS(1)PLQAMSSYTVAGR;EVMS(0.999)PLQAMS(0.001)SYTVAGR 123.92 0.0013311 17614300.0 2484.71 2540.8 2773.0 3228.2 2767.4 2409.05 3003.8999999999996 2578.3 1470.67 2460.1 True False 2542.5989085959663 2243.321954814126 2396.4418309986822 2664.4554708190817 2517.0891586241537 2384.8171442423914 2777.313404546235 2509.91510850129 2495.6195765130524 2775.8777984032513 0.9159621183823465 0.8081486714236975 0.8633095564859413 0.9598605069544984 0.9067723226404423 0.8591218048626611 1.00051717195325 0.9041878968681729 0.8990379828494576 1.0 11.438728342665382 -2.188938534995139 0.01916842333476547 1.6475484935029898 3.3946575316646395e-07 0.31940386268972276 0.048170077292583637 3589.4036270924175 5.944038641402709 197.648969222288 328.20211186140415 0.0064723421129164 2.188938534995139 -1.6475481540372368 EVMS(ph)PLQAMSSYTVAGR ddPTM_A459_Selumetinib_30min_R2 2 EVMSPLQAMSSYTVAGR 17 0 Q9BYT8 Q9BYT8 NLN Neurolysin, mitochondrial 1 EVMS(0.998)PLQAMS(0.002)SYTVAGR;EVMS(0.998)PLQAMS(0.001)SYTVAGR 82.774 0.014006 3994900.0 9158.8 8465.8 12345.3 10120.6 10622.9 8460.599999999999 9283.1 8166.400000000001 6904.0 10169.3 True False 8649.790561581332 9115.099638162576 11551.016838546335 8742.156820991206 9288.356332069065 9625.97085232004 9714.78254411368 8190.1628719797045 8284.9929138776 9875.685885985473 0.8758673231857443 0.9229839571039576 1.169641984557074 0.885220218820158 0.9405277202315756 0.974714157928028 0.9837071223478128 0.8293259796367477 0.8389283549039146 1.0 13.269665234352795 -7.7496607017068895 24.94991049824838 0.8755953711346011 0.9673490667115788 0.12620709177392164 0.08832202984618663 360.8325160632021 764328.9433313108 0.04206267876746468 0.024028636931812813 1.7796692571342078e-08 7.7496607017068895 0.09175369557697777 EVMS(ph)PTGSAR ddPTM_A459_Selumetinib_30min_R1 1 EVMSPTGSAR 10 0 H0YHB7;O43347 H0YHB7 MSI1 RNA-binding protein Musashi homolog 1 1 EVMS(0.992)PT(0.007)GS(0.001)AR 112.64 0.008112300000000001 5118400.0 2082.7 1906.9 2240.1 2462.8 2543.2 1846.9 2382.0 2108.6 1086.9 1601.7 True False 2131.2228577712576 1683.6392615062398 1935.906723988514 2032.7182124816418 2313.168009038427 1828.321862851028 2202.3238222407967 2052.67307830191 1844.3899159648568 1807.2937968791884 1.1792343123466842 0.9315802800925485 1.0711632648390719 1.124730365362684 1.2799070151365404 1.011635112126291 1.2185754336366013 1.1357716613903281 1.0205257823325269 1.0 10.819615336989175 -4.461070803794436 23.443396636920056 1.0980665882209537 3.4615485264232855 0.06103678266252688 0.100629252310334 2273.5402554667635 848589.5033339211 0.024332457421440582 4467.2480980694045 3.4588298331712275e-05 4.461070803794436 2.363481938202332 EVMS(ph)PTGSAR ddPTM_A459_Selumetinib_30min_R2 1 EVMSPTGSAR 10 0 H0YHB7;O43347 H0YHB7 MSI1 RNA-binding protein Musashi homolog 1 1 EVMS(0.996)PT(0.004)GSAR 100.09 0.017800999999999997 9532900.0 15956.0 17073.0 31798.0 31804.0 33713.0 23765.0 24664.0 23426.0 35901.0 23450.0 True False 15069.229396928822 18382.444201652506 29752.151299044668 27472.24033503985 29477.671541956013 27038.41303280924 25810.924870788826 23494.165781616925 43082.203157751974 22772.937569582893 0.6617165374859818 0.8072056644200951 1.3064696290558357 1.2063547028615962 1.294416737054091 1.1873045780849814 1.1334034000630502 1.031670407466332 1.8918158022483467 1.0 14.475032781859234 -5.16755303546706 3.9004257267706537 1.2507472387494132 0.6928047609478679 0.44526660874198987 0.2346856489344166 0.20319855316983562 5.555828989306727 0.0583303254807677 0.1775968576126984 6.799030110780078e-06 5.16755303546706 -0.5579424778015453 EVNS(ph)QEEEEEELLRK ddPTM_A459_Selumetinib_30min_R1 2 EVNSQEEEEEELLRK 15 1 Q96RL1-2;Q96RL1-3;Q96RL1;D6RC40;D6RCQ3;Q96RL1-5 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 EVNS(1)QEEEEEELLRK;EVNS(1)QEEEEEELLRK 167.9 3.5799e-05 13326300.0 2579.5 2915.0 3723.6000000000004 3629.4 3502.7 3045.8 2600.0 2845.2 1784.95 2666.0 True False 2639.597331166735 2573.7104448532655 3217.9555722707173 2995.59342227581 3185.881403451911 3015.1620173651345 2403.8799067279897 2769.7360534879044 3028.9297824100395 3008.2070690390915 0.8774653042783717 0.8555629269481716 1.0697254206302447 0.9958069220390102 1.0590631995521418 1.002311991218166 0.7991071929419601 0.9207265290991549 1.006888725707824 1.0 11.554688162579842 -5.227293172881485 24.770410537575394 0.9763537887018712 0.8665140491311227 0.28435504452734217 0.07270041131565724 828.4954849052277 601006.0013495015 0.020333699214054177 0.053791365175160505 5.925252021422754e-06 5.227293172881485 -0.10983973957074844 EVNS(ph)QEEEEEELLRK ddPTM_A459_Selumetinib_30min_R2 2 EVNSQEEEEEELLRK 15 1 Q96RL1-2;Q96RL1-3;Q96RL1;D6RC40;D6RCQ3;Q96RL1-5 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 EVNS(1)QEEEEEELLRK;EVNS(1)QEEEEEELLRK 161.95 5.9563e-05 19010400.0 19548.5 22247.0 24351.0 28568.0 28677.0 18336.199999999997 17910.6 20241.6 18079.199999999997 25863.0 True False 18462.07262884578 23953.27336462035 22784.283171364154 24676.989117451227 25074.33888436722 20861.845110549002 18743.47838918061 20300.499704822723 21695.54517505444 25116.26798985598 0.7350643270848316 0.9536955639386654 0.9071524153415756 0.9825101853276064 0.9983305996931672 0.8306108661913758 0.7462684502630237 0.8082609929557105 0.8638044945139498 1.0 14.61633449057352 -6.808388420381481 23.884019704166494 0.8313349521474019 0.9207565351057788 0.09696814630118766 0.09102434474109275 135.6598278250615 69011.75775299675 0.03178355427362719 0.028030594168508543 1.5545746432205024e-07 6.808388420381481 0.08942158295837688 EVPPPPAEES(ph)EEEDDDGLPK ddPTM_A459_Selumetinib_30min_R1 2 EVPPPPAEESEEEDDDGLPK 20 0 Q9H6X2-5;Q9H6X2 Q9H6X2-5 ANTXR1 Anthrax toxin receptor 1 1 EVPPPPAEES(1)EEEDDDGLPK;EVPPPPAEES(1)EEEDDDGLPK 88.329 0.0013205 6823800.0 3112.1 3766.1 3464.1 2487.5 3031.9500000000003 3374.7 3421.5 4375.8 2667.2 4302.6 True False 3184.605874907539 3325.163261187609 2993.6942469392475 2053.104821158064 2757.710657834251 3340.7535819824407 3163.4135003345477 4259.739569398416 4526.043595419511 4854.880620873069 0.6559596669000773 0.6849114367285171 0.616636016562006 0.4228950166829947 0.5680285208204198 0.6881227043192798 0.6515944978613419 0.8774138649432688 0.932266712380165 1.0 12.24522010558114 -7.835524692272889 1.385282784786667 0.9910187628085957 0.5943039532301688 0.8145697710378313 0.07209072274833796 0.1958580863000792 0.6851970571059712 0.06737988946294461 0.02487146858804803 1.4604117138258685e-08 7.835524692272889 -0.39671480957842686 EVPPPPAEES(ph)EEEDDDGLPK ddPTM_A459_Selumetinib_30min_R2 2 EVPPPPAEESEEEDDDGLPK 20 0 Q9H6X2-5;Q9H6X2 Q9H6X2-5 ANTXR1 Anthrax toxin receptor 1 1 EVPPPPAEES(1)EEEDDDGLPK;EVPPPPAEES(1)EEEDDDGLPK 108.5 0.00027945 5165700.0 82160.0 40539.0 47064.0 56444.0 43724.0 42944.0 102915.0 77828.0 59478.0 39406.0 True False 77593.87611253894 43648.210946570056 44035.95347940876 48756.22982866903 38231.00022248047 48859.146193181565 107700.75142220361 78054.466594881 71375.26195417321 38268.246390916145 2.0276308279168402 1.1405856045949094 1.1507178309027954 1.2740649082954176 0.9990267082516612 1.2767542493083617 2.814363384253972 2.039666667699961 1.8651301976334036 1.0 15.223860171825944 -7.115800690111161 24.088432719787672 2.020620933659372 1.2803803059858607 0.2704788651502157 0.4868465424127331 16.936287540517277 3488.8611942310117 0.17917324041710497 0.1387870413516726 7.659480412500963e-08 7.115800690111161 -0.7402406276735114 EVPSKEEPS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 3 EVPSKEEPSPVK 12 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EVPS(0.001)KEEPS(0.999)PVK;EVPS(0.004)KEEPS(0.996)PVK;EVPSKEEPS(1)PVK 79.20100000000002 0.02337 148339000.0 20608.2 23447.1 15876.099999999999 15648.6 16917.5 17670.199999999997 20606.6 19861.4 12377.5 21254.3 True False 21088.33096342325 20701.90263173893 13720.212821174968 12915.865770602653 15387.315112027212 17492.45383125791 19052.227571531166 19334.611153080514 21003.71348316774 23982.496439413953 0.8793217593797159 0.8632088274895543 0.5720927700681957 0.5385538491887825 0.6416060626090193 0.7293841938202061 0.7944221995263114 0.8061967694616275 0.8757934577923779 1.0 14.549694222342577 -8.196746709272153 0.9456918224660056 0.9908811582973822 0.6964885276011425 0.4489168879383796 0.10432780385386425 0.5477875493412748 0.9961010844524895 0.11149139553715741 0.040106429386393964 6.357015798271263e-09 8.196746709272153 -0.29439263069623967 EVPSKEEPS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 3 EVPSKEEPSPVK 12 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EVPSKEEPS(1)PVK;EVPSKEEPS(1)PVK;EVPS(0.002)KEEPS(0.998)PVK 150.37 0.0026162 83342000.0 197628.0 149206.0 178300.0 187539.0 184990.0 152053.0 234362.0 214771.0 162173.0 150696.0 True False 186644.62692756637 160649.62042709294 166828.37211836214 161995.8646771804 161749.90236841698 172996.92055029442 245260.29737949264 215395.94805274668 194612.13149221745 146345.01492477008 1.275373999063191 1.0977457654411822 1.1399662106982031 1.1069448779000486 1.1052641762451965 1.1821169353751133 1.6759046934777437 1.4718365922028354 1.3298172923229363 1.0 17.159014077267152 -7.030702153906162 24.115778723006468 1.4116096583626074 1.1403961160551968 0.28445796866913897 0.16491911829840944 451.4950345700584 354636.5456475055 0.05998876088927656 0.04653715256324227 9.317466631442644e-08 7.030702153906162 -0.2712135423074107 EVPSKEEPS(ph)PVKAEVAEK ddPTM_A459_Selumetinib_30min_R1 4 EVPSKEEPSPVKAEVAEK 18 2 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EVPS(0.001)KEEPS(0.999)PVKAEVAEK;EVPS(0.025)KEEPS(0.975)PVKAEVAEK;EVPS(0.016)KEEPS(0.984)PVKAEVAEK;EVPS(0.01)KEEPS(0.99)PVKAEVAEK 83.87100000000002 0.0094947 2400230000.0 25174.299999999996 28425.6 35904.899999999994 36201.1 24295.2 27990.9 26654.1 25973.4 16942.6 25493.899999999998 True False 25760.812209339285 25097.51753729708 31029.21179149822 29879.257463809143 22097.70344966593 27709.33695970374 24643.559777660994 25284.50105850654 28750.35476145568 28766.290396615033 0.8955208285170685 0.8724627747014032 1.0786657356121756 1.0386899753791359 0.7681805038117182 0.9632572214790801 0.8566818813927024 0.8789628662540999 0.9994460309292703 1.0 14.81209156755508 -3.617057801162037 14.156889292403719 0.9309029003696765 0.2809765352459148 0.0 0.09128172077522002 0.0 0.0 0.02120711894033717 0.0 0.0002415139377096544 3.617057801162037 -0.6499263651237617 EVPSKEEPS(ph)PVKAEVAEK ddPTM_A459_Selumetinib_30min_R2 4 EVPSKEEPSPVKAEVAEK 18 2 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 EVPSKEEPS(1)PVKAEVAEK;EVPS(0.023)KEEPS(0.977)PVKAEVAEK;EVPSKEEPS(1)PVKAEVAEK;EVPS(0.01)KEEPS(0.99)PVKAEVAEK 113.01 0.0013509 970666000.0 710936.0 684880.0 666924.0 672607.0 557800.0 458538.0 558531.0 555832.0 346525.0 601667.0 True False 671425.0232222987 737408.0937637083 624014.8359319477 580996.7662882074 487724.1772047295 521697.4473064715 584503.7982081798 557449.3790970588 415839.6827174735 584295.3103913956 1.149119308817554 1.2620469147180877 1.0679785116090452 0.9943546627116027 0.8347220464220789 0.8928660525394388 1.000356819254025 0.9540541729209605 0.7116943698194659 1.0 19.156338184561406 -5.671605733035617 2.0201945369443455 0.9027704919987805 1.2051433482320624 0.6592916328804628 0.0861470422864438 0.19201141315617695 1.5847578469419106 0.025663028145233146 0.055440248286961244 2.130071918567271e-06 5.671605733035617 0.3023728562332819 EVPWS(ph)PSAEK ddPTM_A459_Selumetinib_30min_R1 1 EVPWSPSAEK 10 0 Q5JSZ5;Q5JT00;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 EVPWS(0.992)PS(0.008)AEK 171.49 0.00017303 101580000.0 7128.6 8414.7 7937.0 8979.5 8184.2 6839.5 7534.3 7878.1 4260.9 6720.1 True False 7294.682510159015 7429.503012112104 6859.198994820245 7411.398891090994 7443.940555037865 6770.700839769129 6965.981685100268 7669.147196324708 7230.4360961768925 7582.690294317177 0.962017730781645 0.9797977661938958 0.90458646319247 0.9774102071194234 0.9817017794616645 0.8929153871474098 0.9186688912140986 1.0114018769924344 0.9535449577303348 1.0 12.888494083673459 -7.763522180060664 24.999121769315398 0.9868550593113956 0.9456810114029545 0.26381580443866015 0.03289773517350298 83.63893679684647 1003838.9807725367 0.017433359602779502 0.009029806547037564 1.7237640536025815e-08 7.763522180060664 -0.04117404790844115 EVPWS(ph)PSAEK ddPTM_A459_Selumetinib_30min_R2 4 EVPWSPSAEK 10 0 Q5JSZ5;Q5JT00;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 EVPWS(0.993)PS(0.007)AEK;EVPWS(0.993)PS(0.007)AEK;EVPWS(0.997)PS(0.003)AEK;EVPWS(0.996)PS(0.004)AEK 168.83 0.00025373 102005000.0 656320.0 704820.0 703290.0 741970.0 718980.0 537087.0 593560.0 593360.0 509577.0 652890.0 True False 619844.361857128 758877.4276465026 658041.0870842555 640912.4060303585 628655.3046372476 611065.8590596437 621161.7161168274 595086.5793639639 611506.6387710032 634039.3692880602 0.9776117886072733 1.1968932284104352 1.0378552483628043 1.0108400788266756 0.9915083117679928 0.9637664294344803 0.9796895054234682 0.9385640832243036 0.9644616224031037 1.0 19.274212898576323 -5.8171197408271045 1.994765094378246 0.9701924282196078 1.0903315067623418 0.4137561248060163 0.05264702810695116 0.27380597123704614 2.2252034305484867 0.015445788173317081 0.02890936015925764 1.5236326098867693e-06 5.8171197408271045 0.12013907854273398 EVQAEQPSS(ph)SSPRR ddPTM_A459_Selumetinib_30min_R2 1 EVQAEQPSSSSPRR 14 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPS(0.043)S(0.319)S(0.319)S(0.319)PRR 118.2 0.0070476 0.0 4925.6 5658.5 6849.7 6718.2 7496.0 6725.3 3762.9 6125.9 7686.5 7622.5 True False 4651.854870739073 6092.488755054804 6408.99775938947 5803.169570458577 6554.2854649097435 7651.6490288050545 3937.882306044896 6143.725354802659 9224.01477875437 7402.4186193665555 0.6284236423172113 0.8230402883613402 0.8657978005488569 0.7839558756209831 0.8854248593509848 1.0336687807396423 0.5319723874764962 0.8299618909323982 1.2460812138646238 1.0 12.853781009466244 -1.8390537255154795 0.10070500444880956 1.1311705060607065 2.0452724783297195e-14 0.225696131946028 0.16896328125161228 217.56413015908075 1.6647638043850714 2.263010585587855 33.86927769694914 0.01448592640582973 1.8390537255154795 -1.131170506060686 EVQAEQPSSS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 EVQAEQPSSSSPR 13 0 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPS(0.15)S(0.15)S(0.443)S(0.257)PR 104.7 0.0075540999999999985 1892500.0 969.1 1163.0 1131.9 1275.6 1276.6 850.24 920.42 1119.6 652.36 911.86 True False 991.6781444596562 1026.8354193359683 978.1941970816479 1052.8404059775785 1161.131755402036 841.6873575561525 850.9919783656071 1089.9045710266616 1107.0072735107499 1028.9061132685626 0.9638179146485553 0.9979874801929047 0.9507127856147959 1.0232618821099069 1.1285108917405764 0.8180409725454292 0.8270841891124844 1.0592847656083246 1.0759069843545592 1.0 10.006895628311362 EVQAEQPSSS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 EVQAEQPSSSSPR 13 0 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPS(0.025)S(0.086)S(0.582)S(0.306)PR 93.478 0.021405 0.0 2860.9 3219.0 2899.0 4400.5 3475.5 2735.4 3742.6 2892.2 3301.7 3568.3 True False 2701.9026310901027 3465.886949283629 2712.481496192546 3801.1443087140883 3038.8766186357802 3112.176520511105 3916.6383158212084 2900.615823170515 3962.132257205921 3465.2739074431847 0.779708243347399 1.0001769100673765 0.7827610655441437 1.0969246328694178 0.8769513463592212 0.8981040470787462 1.1302536020048868 0.8370523948886636 1.1433821288110926 1.0 11.758753677224265 -1.9962523545205317 0.26963012319148894 1.020466068861808 1.0546378374203528e-14 0.2010992750066093 0.11791613649846955 70.62658701001759 1.2408194184275594 0.13036129077585243 31.895723923049573 0.010086666121147427 1.9962523545205317 -1.0204660688617975 EVQAEQPSSS(ph)SPRR ddPTM_A459_Selumetinib_30min_R1 1 EVQAEQPSSSSPRR 14 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPS(0.126)S(0.21)S(0.622)S(0.041)PRR 100.27 0.0046778 4971900.0 1702.8 2024.9 2172.5 2156.9 2132.0 1656.5 1810.0 1847.4 949.15 1430.7 True False 1742.4719269279758 1787.8237666495297 1877.4864326882932 1780.2379050274692 1939.1609764351726 1639.8371139816607 1673.4702427606394 1798.4009507990859 1610.638226826796 1614.3442811981358 1.0793682284640957 1.1074612692421721 1.163002498633599 1.1027622334104656 1.20120658215233 1.0157914473885363 1.0366253730701245 1.1140132695018108 0.9977042973952314 1.0 10.65673257071902 -6.781762602313763 24.99993484185158 1.0401900974801683 1.1297015997660576 0.5492036923956536 0.04410656556861889 203.75325030167218 250638.61814326124 0.01530519683232263 0.013513493126190183 1.652865054269966e-07 6.781762602313763 0.08951150228588922 EVQAEQPSSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 5 EVQAEQPSSSSPR 13 0 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPSSS(0.095)S(0.905)PR;EVQAEQPSSS(0.002)S(0.998)PR;EVQAEQPSSS(0.008)S(0.992)PR;EVQAEQPSSS(0.024)S(0.976)PR;EVQAEQPS(0.003)S(0.027)S(0.298)S(0.672)PR 269.05 3.7013e-38 525777700.0 26916.37 33756.0 33526.91 36261.299999999996 32460.799999999996 27947.899999999994 32392.37 28560.87 16174.09 23686.66 True False 27543.469050861157 29803.831827261343 28974.139772134175 29928.944663903087 29524.726371419696 27666.769500662864 29948.987451653302 27803.34294881947 27446.249421205295 26727.07353860672 1.0305456379680016 1.1151176646485559 1.0840745332735966 1.1197987920627122 1.1046748656852319 1.0351589544848137 1.120548697873435 1.0402688834846845 1.0269081417222778 1.0 14.706014258938412 -7.942091944677755 5.373995203883315 1.0193125700534813 1.0879551770723608 0.487556609830224 0.03106339227538619 0.16079446233793052 9.438475278615476 0.017368576716606222 0.007978926818042596 1.142636401120488e-08 7.942091944677755 0.06864260701887948 EVQAEQPSSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 EVQAEQPSSSSPR 13 0 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPSSS(0.002)S(0.998)PR;EVQAEQPSSS(0.02)S(0.98)PR;EVQAEQPSSS(0.007)S(0.993)PR;EVQAEQPSSS(0.017)S(0.983)PR;EVQAEQPSSS(0.033)S(0.967)PR 257.81 1.4709e-29 586312100.0 725422.3 706195.4 776444.1 856898.9 922388.0 683964.1 653816.7 776439.7 576983.2 772355.0 True False 685106.2326615523 760358.3164038949 726488.5319344176 740187.791586948 806509.3731866556 778173.9463670789 684220.4720632135 778699.0109804886 692395.9622575912 750055.1043307114 0.9134078665765307 1.0137366068355433 0.9685802119601296 0.9868445495713701 1.0752668284369844 1.0374890349709152 0.9122269392110284 1.0381890696888687 0.9231267919647442 1.0 19.51663706447774 -1.6604844459804626 13.264647099521714 0.9899704706387922 0.9283593009975417 0.0 0.054189683095861314 0.0 0.0 0.012091703714763825 0.0 0.02185322584385894 1.6604844459804626 -0.06161116964125046 EVQAEQPSSSS(ph)PRR ddPTM_A459_Selumetinib_30min_R1 2 EVQAEQPSSSSPRR 14 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPS(0.011)S(0.026)S(0.208)S(0.754)PRR;EVQAEQPS(0.031)S(0.017)S(0.05)S(0.903)PRR 148.33 0.00082882 4362500.0 1820.05 2382.5 2685.83 2922.68 2366.04 2124.7400000000002 2329.4300000000003 2133.73 1092.48 2010.68 True False 1862.4536237991917 2103.5557924058 2321.109038208148 2412.2888034983916 2152.032099758289 2103.3670447095656 2153.719219665147 2077.136549068166 1853.8587684177835 2268.770363681742 0.8209088295638777 0.9271788040249992 1.023069181158322 1.0632582486593087 0.948545579670738 0.9270956101948717 0.9492892071148661 0.915534062996753 0.8171204975585792 1.0 11.147694876949899 -7.805761949373583 3.680643113296535 0.8966981025758796 0.9569499415513381 0.052040701576746784 0.0728973890274605 0.5641646784629248 15.652450545357443 0.04478317577670217 0.02074809846536166 1.5640046884747203e-08 7.805761949373583 0.060251838975458494 EVQAEQPSSSS(ph)PRR ddPTM_A459_Selumetinib_30min_R2 1 EVQAEQPSSSSPRR 14 1 Q9Y388;A0A1W2PP04 Q9Y388 RBMX2 RNA-binding motif protein, X-linked 2 1 EVQAEQPS(0.025)S(0.043)S(0.346)S(0.585)PRR 90.755 0.009161 6142400.0 18717.0 20291.0 19095.0 20543.0 24176.0 17003.0 19151.0 18217.0 13725.0 21327.0 True False 17676.784070087542 21847.25445415163 17866.44848906404 17745.007961348365 21138.794743817758 19345.008912133635 20041.559446986586 18270.008454013307 16470.38350854144 20711.23409579934 0.853487724986545 1.0548504426678609 0.8626452874040819 0.8567817774290627 1.0206439001191694 0.9340345834851626 0.9676661156107266 0.8821303631404 0.7952391167208124 1.0 14.33812589983142 -7.8201812504114425 9.852680721385306 0.8787437451322235 0.9376429042500162 0.050811201810275985 0.07903954899220654 0.979053585981957 156.1364487847159 0.04163010249044449 0.019997857411620985 1.5129297037756022e-08 7.8201812504114425 0.05889915911779264 EVQDKDYPLT(ph)PPPS(ph)PTVDEPK ddPTM_A459_Selumetinib_30min_R2 1 EVQDKDYPLTPPPSPTVDEPK 21 1 Q5THJ4-2;Q5THJ4;H3BLS7 Q5THJ4-2 VPS13D Vacuolar protein sorting-associated protein 13D 2 EVQDKDY(0.001)PLT(0.999)PPPS(0.994)PT(0.006)VDEPK 140.07 6.9788e-05 3553200.0 53798.0 44953.0 43411.0 47862.0 48803.0 33724.0 43923.0 43026.0 30390.0 44931.0 True False 50808.12253045729 48400.75055332306 40617.983522323084 41343.11303344476 42671.930835644394 38369.17488400839 45965.50653177336 43151.198536662254 36468.84916754639 43633.725285242195 1.1644232115941202 1.1092509346134873 0.9308850724249507 0.9475036285161705 0.9779575444610709 0.8793467583430383 1.0534398846600388 0.9889414267192276 0.8357949941047296 1.0 15.413156030461042 -5.158432888826398 3.901177442221801 0.9531032382387592 1.1527931413357346 0.618204766964968 0.05869142668269831 0.14676964699198056 3.9241560360654604 0.01501114345868443 0.046077983871088364 6.943318879672644e-06 5.158432888826398 0.19968990309697543 EVQSPEGMIS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 EVQSPEGMISLR 12 0 A0A0A0MRW6;Q9H6R4-2;Q9H6R4-4;Q9H6R4 A0A0A0MRW6 NOL6 Nucleolar protein 6 1 EVQS(0.285)PEGMIS(0.715)LR 92.295 0.021864 1770800.0 11079.0 6289.8 7174.6 9481.3 9488.9 5629.2 6873.6 7327.5 6392.3 7140.7 True False 10463.273532750967 6772.207435105369 6712.994047113843 8189.93058384522 8296.81955015769 6404.571203210177 7193.236019780012 7348.821811867075 7670.938615785017 6934.529437233288 1.5088656883581655 0.9765922109643993 0.9680532915571799 1.1810362416044204 1.196450260288739 0.9235769003765955 1.0373070133869013 1.0597434012478688 1.1061945421412096 1.0 12.759582272242964 -6.743348675179397 24.998012258548634 1.0298447114689417 1.145481933264211 0.18053716286096744 0.1465867689588806 536.4457811628945 741267.550946 0.04886250916196882 0.04876957313041804 1.8057238108203206e-07 6.743348675179397 0.11563722179526925 EVQTPQYLNPFDEPEAFVT(ph)IKDSPPQSTKR ddPTM_A459_Selumetinib_30min_R1 1 EVQTPQYLNPFDEPEAFVTIKDSPPQSTKR 30 2 Q8NDI1-3;Q8NDI1-2;Q8NDI1;B5MC86 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 EVQTPQYLNPFDEPEAFVT(0.889)IKDS(0.103)PPQS(0.006)T(0.002)KR 73.654 9.8817e-05 22352000.0 2899.8 2804.6 4615.9 4609.2 3472.1 2800.6 2999.2 3220.4 1840.5 2488.2 True False 2967.3596979714275 2476.2361281768344 3989.0861333237694 3804.2897453996975 3158.0491680490436 2772.428506741344 2772.967929330226 3134.9845306665447 3123.1940751985658 2807.5847071204325 1.0569083420513665 0.881980914733133 1.4208248546185915 1.355004440561127 1.1248277425218136 0.9874781336819767 0.9876702641589358 1.1166126253344306 1.1124131240912174 1.0 11.455113835230625 -6.529016381510404 21.518486801711244 1.0460615387289132 1.1829245400358495 0.1675919436309622 0.14525784317282614 59.14126192860435 207337.56505680145 0.052599922380977784 0.05283296501552835 2.9579008929531294e-07 6.529016381510404 0.1368630013069363 EVQTPQYLNPFDEPEAFVTIKDS(ph)PPQSTK ddPTM_A459_Selumetinib_30min_R1 2 EVQTPQYLNPFDEPEAFVTIKDSPPQSTK 29 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1;B5MC86 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 EVQTPQYLNPFDEPEAFVT(0.169)IKDS(0.83)PPQS(0.001)TK;EVQTPQYLNPFDEPEAFVT(0.027)IKDS(0.971)PPQS(0.001)T(0.001)K 108.49 4.9735e-11 42695000.0 6791.5 8032.5 8257.5 8883.2 7792.8 7034.3 7104.2 7544.7 4282.6 6586.5 True False 6949.728736041431 7092.051165792061 7136.176855200728 7331.91587831611 7087.942615930582 6963.5413286333805 6568.324474375765 7344.590047360537 7267.259411271601 7431.941432942979 0.9351161871696025 0.9542662882615955 0.9602035914288507 0.9865411271698814 0.9537134650324907 0.9369747314970274 0.883796587155662 0.9882464916643118 0.9778413186975067 1.0 12.859523417338567 EVQTPQYLNPFDEPEAFVTIKDS(ph)PPQSTKR ddPTM_A459_Selumetinib_30min_R1 1 EVQTPQYLNPFDEPEAFVTIKDSPPQSTKR 30 2 Q8NDI1-3;Q8NDI1-2;Q8NDI1;B5MC86 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 EVQTPQYLNPFDEPEAFVT(0.296)IKDS(0.595)PPQS(0.089)T(0.02)KR 59.18 0.0012594 20738000.0 1740.5 1327.2 2636.2 2809.3 1991.0 2001.6 1802.6 1722.5 1065.4 1635.2 True False 1781.050263576547 1171.810807001459 2278.2185196100695 2318.7084920922016 1810.9144015395993 1981.46572130739 1666.628430718413 1676.8137045314618 1807.9059862627287 1845.0938481968215 0.9652897955933986 0.6350955037580606 1.2347439789236376 1.2566886472242242 0.9814754969289908 1.0739105348185092 0.9032756964352683 0.9087958892552718 0.979845002480261 1.0 10.849478483541128 -7.266401145121874 24.602999032864147 0.9403788091582421 1.0249825214124866 0.04960488410205732 0.16279923572393004 1254.5407097339637 6220625.380949952 0.07228437041527165 0.050483498708305326 5.415004911553009e-08 7.266401145121874 0.08460371225424446 EVS(ph)DDEAEEK ddPTM_A459_Selumetinib_30min_R2 1 EVSDDEAEEK 10 0 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 EVS(1)DDEAEEK 84.18799999999997 0.038289 9537900.0 23091.0 15467.0 18657.0 23485.0 22918.0 21243.0 35072.0 50631.0 38759.0 23793.0 True False 21807.694660596855 16653.26916575642 17456.62893220569 20286.3024861153 20038.835950480472 24169.030425245808 36702.91749384959 50778.327827586734 46511.88301694409 23106.03426836188 0.9438095004670366 0.7207324706758114 0.7555008674122984 0.877965567370965 0.8672555280470092 1.0460051320160744 1.5884559447791242 2.1976219388333273 2.01297559229499 1.0 14.49598204816841 -7.254078007660118 2.5780556792106095 1.8379936871598428 0.8318253125113656 0.6463514120197611 0.30195150614306604 0.1578244071685696 2.0756406921451855 0.1339277509599425 0.08997590626005872 5.570856766192117e-08 7.254078007660118 -1.0061683746484773 EVS(ph)DSEAGGGPQGER ddPTM_A459_Selumetinib_30min_R2 2 EVSDSEAGGGPQGER 15 0 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 EVS(0.987)DS(0.013)EAGGGPQGER;EVS(1)DSEAGGGPQGER 206.13 3.7298e-09 32933000.0 11564.2 11809.5 15694.6 16121.9 12985.7 12129.2 19686.0 20336.1 21939.8 13001.599999999999 True False 10921.508059160466 12715.250676472513 14684.826522988446 13926.069408171268 11354.320272369063 13799.887202085 20601.438007068977 20395.274684177417 26328.37304923113 12626.210025786308 0.8649870417849571 1.0070520489128851 1.1630431058090953 1.102949291967287 0.8992659118754017 1.092955619612038 1.6316406875059886 1.6153124843103728 2.0852158324201095 1.0 13.624134033912858 -7.234537536260723 4.449817855360734 1.6390876187456995 1.0200326945892269 0.5255348773929669 0.25985454283511233 0.1502898971723773 7.402178787573735 0.10092649927623124 0.07371943117036377 5.827234075825241e-08 7.234537536260723 -0.6190549241564727 EVS(ph)PAPAVAGQSK ddPTM_A459_Selumetinib_30min_R1 4 EVSPAPAVAGQSK 13 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK 188.92 0.00010155 575069000.0 23727.300000000003 24408.6 25822.6 27102.4 25332.800000000003 20779.1 22642.4 19901.5 11937.599999999999 17850.9 True False 24280.09992471116 21550.829764749702 22316.032753388605 22369.474615057006 23041.4527128691 20570.08111991326 20934.46553849918 19373.647570817357 20257.235312192555 20142.236897490602 1.2054321497795546 1.0699322957240458 1.1079222663779127 1.1105754901454805 1.1439371322129417 1.0212411473760374 1.0393317110229836 0.9618419080966624 1.005709316958549 1.0 14.297936290387382 -6.8415559816327685 4.8658862235101354 1.0028929455117457 1.1222723775686942 0.7315296991087634 0.03693963484936795 0.11517470632986873 4.871266213124213 0.013126384511735435 0.011659569725490348 1.4402703438709574e-07 6.8415559816327685 0.11937943205694856 EVS(ph)PAPAVAGQSK ddPTM_A459_Selumetinib_30min_R2 6 EVSPAPAVAGQSK 13 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK;EVS(1)PAPAVAGQSK 209.53 8.300299999999999e-06 624665600.0 1910046.0 1813709.0 2142318.0 2190201.0 2174829.0 1599751.0 1681431.0 1716495.0 1301192.0 1776538.0 True False 1803893.2898399534 1952814.6483063835 2004483.5922594797 1891891.8454925402 1901607.5378020562 1820102.1791563048 1759620.8731923203 1721489.7162689548 1561466.758342154 1725244.731939945 1.045586899321566 1.1319058752380877 1.1618546372870506 1.0965933183086491 1.1022248047462813 1.0549820239762147 1.0199253709435885 0.997823488110717 0.9050697152898237 1.0 20.718369597019368 -7.305860673163515 1.1638388953271506 0.957007494094213 1.1143044316543245 0.7395597919720558 0.03654103629095666 0.2421604509990743 0.6334709906707314 0.025226261128756516 0.013843974115246977 4.9446929317592436e-08 7.305860673163515 0.15729693756011143 EVS(ph)PEVVR ddPTM_A459_Selumetinib_30min_R1 4 EVSPEVVR 8 0 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 EVS(1)PEVVR;EVS(1)PEVVR;EVS(1)PEVVR;EVS(1)PEVVR 120.99 0.0071153000000000015 294768000.0 18114.7 20032.800000000003 21674.8 21750.0 21051.100000000002 16882.9 20220.5 18373.8 11032.7 14838.0 True False 18536.73726492965 17687.35046300394 18731.481211154078 17951.770798065496 19147.03172187358 16713.073354446715 18695.251405382056 17886.467137486317 18721.68610347364 16742.60183435935 1.107159893564951 1.0564278263313749 1.118791535298482 1.0722210905848981 1.1436114835258062 0.9982363266949325 1.1166276060519733 1.0683206418239914 1.1182064943486139 1.0 14.031236122601962 -6.723189712375387 24.99996204135391 1.0680695811847418 1.096781919967505 0.1539328249227948 0.044043902896250556 407.73848483350406 266496.5202865781 0.013750667800810554 0.01375035240842665 1.8915171688089563e-07 6.723189712375387 0.028712338782763247 EVS(ph)PEVVR ddPTM_A459_Selumetinib_30min_R2 4 EVSPEVVR 8 0 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 EVS(1)PEVVR;EVS(1)PEVVR;EVS(1)PEVVR;EVS(1)PEVVR 109.29 0.012513 440808100.0 1203751.0 1171870.0 1289799.0 1324111.0 1351223.0 952726.0 1009242.0 1008441.0 856909.0 1160045.0 True False 1136851.3384170511 1261748.6608440524 1206814.7365669694 1143764.7975811213 1181470.286653114 1083955.3585144628 1056173.7527750845 1011375.3963536053 1028314.7440379387 1126551.4866911198 1.009142814906919 1.1200097605392458 1.0712468545149205 1.015279648638661 1.048749480703541 0.9621889201870664 0.9375281691538598 0.897762249042157 0.9127987102109999 1.0 20.103481819778587 -6.806101425918186 1.622881717244 0.926301514213276 1.062173561310395 0.670579577898639 0.03871390950177188 0.20293136750068286 1.1068994923078688 0.01680893849613334 0.014756768291689445 1.5627826249405858e-07 6.806101425918186 0.1358720470971191 EVS(ph)PGAGTEVQDALER ddPTM_A459_Selumetinib_30min_R1 2 EVSPGAGTEVQDALER 16 0 Q6SZW1 Q6SZW1 SARM1 Sterile alpha and TIR motif-containing protein 1 1 EVS(1)PGAGTEVQDALER;EVS(1)PGAGTEVQDALER 212.59 2.8031e-08 11675800.0 2107.8 2319.82 2467.81 3079.6 2290.4 1859.5700000000002 2485.1 2140.66 1390.9 1753.9099999999999 True False 2156.907638935158 2048.21439594494 2132.6949567100114 2541.8056712516095 2083.233724402964 1840.864414154469 2297.6469062345104 2083.8827429563544 2360.255712683338 1979.0414330301394 1.0898749277991038 1.034952761352191 1.0776403773642125 1.2843620294294766 1.0526478575101352 0.9301798251570178 1.160989794294781 1.0529758034250405 1.1926257193461158 1.0 10.9505861014949 EVS(ph)PGAGTEVQDALER ddPTM_A459_Selumetinib_30min_R2 2 EVSPGAGTEVQDALER 16 0 Q6SZW1 Q6SZW1 SARM1 Sterile alpha and TIR motif-containing protein 1 1 EVS(1)PGAGTEVQDALER;EVS(1)PGAGTEVQDALER 166.48 1.6365e-05 4757900.0 14645.5 14510.0 14332.1 18613.199999999997 17442.3 14690.0 16287.0 15455.0 13920.5 14588.8 True False 13831.561740581663 15622.870342996406 13409.988289610612 16078.050050439055 15251.042337859564 16713.414157457093 17044.377772078235 15499.971491287026 16704.988971267827 14167.58343774546 0.9762823562225466 1.1027194871761794 0.9465261558921578 1.1348477403424853 1.0764745028589378 1.1796940692742983 1.2030546950348908 1.0940448354792676 1.1790993887328858 1.0 13.790306078546536 -5.785650675481361 24.81565206966292 1.1314547841662144 1.0179303551758645 0.37510735007047524 0.0674241152790832 204.6036697135806 209710.13842609397 0.018115907493680646 0.02688618241069711 1.6381336234967195e-06 5.785650675481361 -0.11352442899034987 EVS(ph)PLLPK ddPTM_A459_Selumetinib_30min_R1 3 EVSPLLPK 8 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 EVS(1)PLLPK;EVS(1)PLLPK;EVS(1)PLLPK 105.98 0.013925 31866800.0 16664.699999999997 13222.6 13129.6 12365.6 14270.899999999998 9605.0 14923.7 16461.5 9510.5 15112.100000000002 True False 17052.955086138503 11674.491844980032 11346.672435730374 10206.180091060167 12980.099614732033 9508.382420642223 13797.993293860196 16024.88754551214 16138.623880562867 17051.88523931946 1.0000627406767069 0.6846452272655548 0.6654204081532523 0.5985367569520128 0.7612119969469174 0.5576147321656325 0.8091769971594573 0.9397721906174223 0.9464422058945875 1.0 14.057643630532677 -7.635705805910999 3.3819209427223855 0.9602209963854361 0.7036345068488842 0.4920618308600593 0.11340948049560577 0.20549824725857743 4.589672160862885 0.06031381870244463 0.031840862166369714 2.3136315294728006e-08 7.635705805910999 -0.25658648953655194 EVS(ph)PLLPK ddPTM_A459_Selumetinib_30min_R2 4 EVSPLLPK 8 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 EVS(1)PLLPK;EVS(1)PLLPK;EVS(1)PLLPK;EVS(1)PLLPK 106.2 0.013829 46338500.0 425416.0 368945.0 426829.0 402794.0 374422.0 325574.0 380382.0 396196.0 311798.0 329761.0 True False 401773.0817951783 397241.89515484485 399367.2868362771 347932.7623415932 327383.76098484994 370418.86323348735 398070.516712634 397348.86476622097 374166.3123640214 320239.94310802646 1.2546001535468931 1.2404508047918412 1.247087677321872 1.0864752190648033 1.0223077040530626 1.1566916345239733 1.2430383069933064 1.2407848343645982 1.1683936386342786 1.0 18.28879373897408 -11.672902969362932 2.011369242701134 0.6337185296567376 1.1828331418284503 0.3552040047902698 0.07451653752496465 2070327.688311158 451808.97342737525 3455177.564685501 0.023380124149447762 2.1237188930319286e-12 11.672902969362932 0.5491146121717128 EVS(ph)PPGAR ddPTM_A459_Selumetinib_30min_R1 2 EVSPPGAR 8 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 EVS(1)PPGAR;EVS(1)PPGAR 101.46 0.017015 110540000.0 1710.13 2410.6 2790.0 2863.8999999999996 2501.6 2323.9 2433.1 2185.14 1098.35 1957.17 True False 1749.972701666279 2128.3658313424644 2411.1333243729996 2363.7736270611363 2275.3307216933513 2300.5236759323757 2249.5693080999517 2127.182988864951 1863.8197296899439 2208.3918339502015 0.7924194768172378 0.9637627700947469 1.0918050353682704 1.0703597028037364 1.0303111461988221 1.0417189742172592 1.0186459094426623 0.9632271575013069 0.8439714823415582 1.0 11.108780456209173 -10.31588668996768 10.80355216125161 0.9999921702878204 0.9890734017642236 0.0 0.09140234244892301 0.0 0.0 0.09288275979188289 0.0225273782012239 4.83184851418182e-11 10.31588668996768 -0.010918768523596745 EVS(ph)PPGAR ddPTM_A459_Selumetinib_30min_R2 1 EVSPPGAR 8 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 EVS(1)PPGAR 83.647 0.038396 51055000.0 12859.0 9815.2 15039.0 16816.0 18503.0 10645.0 7266.0 9902.0 7502.7 16025.0 True False 12144.348258655538 10567.994279157709 14071.407113225136 14525.63179078197 16178.487721081256 12111.252124311148 7603.88339730586 9930.813180635654 9003.449642953283 15562.316612049712 0.780368923303637 0.679075907694555 0.9041974574871339 0.9333849293064087 1.0395937908469521 0.7782422390078835 0.48860870697221687 0.6381320614532637 0.5785417343316368 1.0 13.925769215962598 -7.00720706234102 24.628640492161367 0.6443450181005801 0.8672178745898493 0.24797241841890305 0.15281102806154812 338.6338381046727 1157213.0974749457 0.05525119664801316 0.04680798992152925 9.835420620888395e-08 7.00720706234102 0.22287285648926924 EVS(ph)PSDVR ddPTM_A459_Selumetinib_30min_R1 1 EVSPSDVR 8 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 EVS(0.895)PS(0.105)DVR 116.52 0.0093122 16827000.0 6114.8 11337.0 4847.1 5974.5 6328.6 6155.2 7023.4 6466.2 3321.3 6391.3 True False 6257.262942670419 10009.658769571695 4188.890443214465 4931.165730254815 5756.17924740508 6093.284276474441 6493.619283428219 6294.695370822256 5636.00352184569 7211.685611533967 0.8676560903685128 1.3879776946408766 0.5808476227131959 0.6837743623166522 0.7981739023951583 0.8449181792851844 0.9004301675384583 0.8728466144939642 0.7815098751437224 1.0 12.816120789506776 -5.265511109011764 24.9999863836512 0.8031301971135176 1.1278168859352136 0.39153812253865816 0.15948239939032094 305.25164283643386 1874224.2241345898 0.04028286784161196 0.08912262385966747 5.426113714538249e-06 5.265511109011764 0.32468668882169593 EVS(ph)PSDVR ddPTM_A459_Selumetinib_30min_R2 2 EVSPSDVR 8 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 EVS(0.995)PS(0.005)DVR;EVS(0.85)PS(0.15)DVR 99.788 0.018368 149122000.0 343160.0 284265.0 370490.0 371970.0 385730.0 293050.0 343470.0 424280.0 368230.0 316940.0 True False 324088.5409783217 306067.2114439614 346653.0767590118 321307.0443159596 337271.1489300475 333414.97745696426 359442.0355728934 425514.5845566648 441886.2892058432 307789.11869098456 1.052956460438426 0.9944055616574545 1.1262681352521953 1.0439194396555223 1.0957864604325485 1.0832578450952572 1.1678191779540055 1.382487419848896 1.4356787240730562 1.0 18.231582703217796 -7.519211138327173 3.5156789398312482 1.3057636296632626 1.067342011303878 0.39051111810160133 0.11311727091543673 0.20135066117436898 5.3222144184605575 0.0531311419311609 0.03087204223913617 3.025442209523976e-08 7.519211138327173 -0.23842161835938458 EVS(ph)S(ph)LEGSPPPCLGQEEAVCTK ddPTM_A459_Selumetinib_30min_R1 1 EVSSLEGSPPPCLGQEEAVCTK 22 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 2 EVS(0.725)S(0.754)LEGS(0.521)PPPCLGQEEAVCTK 76.691 0.0083458 0.0 513.41 673.61 584.16 796.69 632.25 636.85 714.36 503.57 432.57 708.86 True False 525.3714540780431 594.7434280472067 504.83428056119385 657.5630472234845 575.0630991328038 630.443867213535 660.4752500654645 490.2136877741124 734.0396963372145 799.8490858811141 0.6568382253000811 0.7435695539890967 0.6311619147567922 0.8221088938285311 0.7189645012837816 0.7882035228171046 0.8257498342176445 0.6128827255382717 0.9177227420702695 1.0 9.643584010287942 -14.522878744222222 0.13628044406580042 1.9013331152962492 0.644488677483457 0.5286618829146204 0.08149842263383093 111.54704471632238 0.9383534174226417 27.134069902889216 0.5163135852152977 3.000000007309203e-15 14.522878744222222 -1.2568444378127923 EVS(ph)SRPS(ph)TPGLSVVSGISATSEDIPNKIEDLR ddPTM_A459_Selumetinib_30min_R2 2 EVSSRPSTPGLSVVSGISATSEDIPNKIEDLR 32 2 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 2 EVS(0.528)S(0.528)RPS(0.459)T(0.459)PGLS(0.023)VVS(0.002)GISATSEDIPNKIEDLR;EVS(0.469)S(0.469)RPS(0.377)T(0.377)PGLS(0.292)VVS(0.015)GIS(0.001)ATSEDIPNKIEDLR 87.352 7.0975e-07 13079700.0 49617.0 38270.0 46724.0 54904.0 55389.0 41294.0 42572.0 36145.0 33519.0 46188.0 True False 46859.485772588196 41205.185942554985 43717.828709244735 47425.98048531721 48430.538636057376 46981.8736703903 44551.682354817625 36250.17596587311 40223.736599111144 44854.432429163986 1.0447013424278788 0.9186424554056716 0.9746601693887393 1.0573309685773935 1.0797269302769783 1.0474298999231806 0.9932503866853186 0.808173774645815 0.8967616893299044 1.0 15.452962936101128 -7.605273791651399 7.634996374717461 0.8900080869384953 1.0182632709537036 0.4263102690873384 0.06127058447562133 0.21796197917633278 17.357556345312837 0.030125080654202316 0.0172941541283175 2.481568160574987e-08 7.605273791651399 0.1282551840152083 EVS(ph)SRPSTPGLSVVSGISATSEDIPNKIEDLR ddPTM_A459_Selumetinib_30min_R1 1 EVSSRPSTPGLSVVSGISATSEDIPNKIEDLR 32 2 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 EVS(0.249)S(0.249)RPS(0.249)T(0.249)PGLS(0.005)VVSGISATSEDIPNKIEDLR 62.049 0.00025448 29062000.0 1209.3 1255.1 1047.4 1335.6 1287.1 1120.4 1255.9 1211.6 730.16 920.61 True False 1237.4743371118172 1108.1523085198392 905.1688329563727 1102.3625323170695 1170.6820322559613 1109.1297932418065 1161.1664518691086 1179.4644321685462 1239.028191223572 1038.7792610007796 1.1912774769103602 1.0667832427191744 0.8713774590419874 1.0612096079536981 1.1269786336782506 1.0677242364015334 1.1178182848494866 1.135433172811159 1.1927733232081172 1.0 10.020673400989736 -6.009300723762152 24.940198793614787 1.1105157760632647 1.0323070939546264 0.09960657706143394 0.08609002296885375 892.9881475125823 2394585.939734908 0.025479309292400384 0.035579395211345566 9.788119801202225e-07 6.009300723762152 -0.0782086821086383 EVS(ph)TYIK ddPTM_A459_Selumetinib_30min_R1 2 EVSTYIK 7 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 EVS(0.935)T(0.065)YIK;EVS(0.86)T(0.14)YIK 120.99 0.009022399999999998 49007000.0 10657.3 14914.4 10900.1 11656.8 15085.7 12612.400000000001 18044.3 18279.300000000003 5886.8 14195.0 True False 10905.594354504066 13168.215114483542 9419.92628996348 9621.158705236308 13721.20109859665 12485.530707142952 16683.203923450725 17794.473584465577 9989.469645139321 16017.066521008976 0.6808733884072726 0.8221365065326598 0.5881180725326777 0.6006816974017434 0.8566613044029675 0.7795141944853733 1.041589226189952 1.1109695749296693 0.6236766034552279 1.0 13.967322326102623 -6.723806474040723 1.815261571507227 0.9438757926122593 0.6835507886381849 0.383396727463593 0.14221409947565772 0.36160084133315606 2.4603623716380354 0.05801132421810621 0.05453662593216045 1.8888328443759078e-07 6.723806474040723 -0.26032500397407443 EVS(ph)TYIK ddPTM_A459_Selumetinib_30min_R2 3 EVSTYIK 7 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 EVS(0.98)T(0.02)YIK;EVS(0.5)T(0.5)YIK;EVS(0.5)T(0.5)YIK 113.66 0.014043 48020000.0 228292.0 168692.0 215681.0 220019.0 219103.0 173311.0 211709.0 234213.0 203664.0 189725.0 True False 215604.44456528442 181630.13396972828 201804.31927571725 190052.0326460554 191577.32233432782 197183.01708938373 221553.88799342478 234894.5210539507 244402.4908476203 184247.1462852501 1.1701915004506347 0.9857961853505715 1.0952914242877079 1.031505977041393 1.0397844753466585 1.0702093414467673 1.2024820598871944 1.2748882454346875 1.32649267994218 1.0 17.491282748725943 -7.285680832149119 3.9973849790538596 1.227343383417019 1.0593986491489653 0.33175225364394845 0.09165700815639509 0.21053892054126375 7.740046434027623 0.037154157778860455 0.025463755574953825 5.1798736678774956e-08 7.285680832149119 -0.16794473426805379 EVS(ph)TYIKK ddPTM_A459_Selumetinib_30min_R1 1 EVSTYIKK 8 1 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 EVS(0.842)T(0.158)YIKK 125.97 0.0088979 14674000.0 1014.2 1164.5 1683.7 1715.3 1298.9 1265.5 1444.5 1352.0 798.29 1236.6 True False 1037.8288867103324 1028.1597986386375 1455.0627879020847 1415.7550551688144 1181.4147243394211 1252.770218982066 1335.5402020263773 1316.1405680850717 1354.6398252052493 1395.329655504029 0.7437875935743958 0.7368579851957922 1.0428093333804178 1.0146384043256123 0.8466921918266431 0.8978309993200374 0.9571503026243255 0.9432470405064585 0.9708385540733874 1.0 10.446390292863919 -5.246262381016345 24.73300672406619 0.952827834892975 0.7403227324489227 0.7253420165855908 0.053750101552793556 388.9888076835777 633907.7911980934 0.014714527414463772 0.038592653161338135 5.672018242717102e-06 5.246262381016345 -0.2125051024440523 EVSCPMSSSQEVVSCLR ddPTM_A459_Selumetinib_30min_R1 1 EVSCPMSSSQEVVSCLR 17 0 E7EVM0;H0YBY1;P01266-2;P01266 E7EVM0 TG Thyroglobulin 0 94.339 0.0096123 3065600.0 2149.7 2339.4 2343.8 2096.6 2104.2 2113.6 2118.5 2259.3 1028.0 1755.7 False True 2199.783827411952 2065.5019604424456 2025.5248335718395 1730.4681680562796 1913.875481526683 2092.3391029952536 1958.6998393858646 2199.3760247593223 1744.4409178506528 1981.061196966217 1.1104068015570066 1.0426240055610299 1.0224443528921336 0.8735056598485227 0.9660859969684824 1.0561708574169475 0.9887124347220588 1.1102009509486284 0.8805588239889193 1.0 10.95205773187384 -4.978317124444603 2.11432503986851 0.9886456738527688 1.117102541203704 0.24966670721072248 0.06770757777036608 0.6806618215696083 4.675070757973231 0.018499599878503595 0.14431542772983044 1.0511940053166662e-05 4.978317124444603 0.1284568673509351 EVSFQS(ph)TGESEWK ddPTM_A459_Selumetinib_30min_R1 1 EVSFQSTGESEWK 13 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 1 EVSFQS(0.693)T(0.053)GES(0.253)EWK 187.37 0.00014031 20694000.0 1342.2 1966.3 1429.1 1419.3 1537.8 1551.9 1961.7 1613.2 793.77 1423.1 True False 1373.470648533433 1736.0846818919292 1235.0360694843907 1171.4458985606605 1398.7062615206405 1536.2892950124597 1813.7273896262698 1570.4126955878992 1346.969715332989 1605.768747167866 0.8553352722525315 1.0811548580416108 0.7691244904738956 0.7295234140200876 0.8710508683068925 0.9567313461057522 1.1295072175400012 0.9779818534628195 0.8388316921154885 1.0 10.649048424505843 -6.816986099392197 4.386935293395176 0.9914194376185196 0.8604958978769073 0.23510098090801446 0.10824285881820003 0.33627267117256004 13.231183513158815 0.041610712195915465 0.0373949056810176 1.5241015354409233e-07 6.816986099392197 -0.1309235397416123 EVSFQS(ph)TGESEWK ddPTM_A459_Selumetinib_30min_R2 1 EVSFQSTGESEWK 13 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 1 EVS(0.072)FQS(0.835)T(0.072)GES(0.021)EWK 91.845 0.023312 0.0 12830.0 12502.0 10756.0 10520.0 9922.7 10090.0 9250.7 10446.0 7120.3 8862.8 True False 12116.959962559342 13460.863199734053 10063.970670247329 9087.15785198777 8676.12171593649 11479.805912099528 9680.875879914302 10476.396130571602 8544.558957804553 8606.90793568014 1.4078180053870681 1.5639604025426748 1.1692899175239113 1.0557981937179486 1.0080416545376794 1.3337897881432799 1.1247797643776347 1.2172078763781655 0.9927559376327104 1.0 13.071279321696156 -5.333001399619004 5.435772993781015 1.1204078270940447 1.4849154474101331 0.6584224348177614 0.1076782887056523 0.11804243602010607 6.442007582825207 0.028080651776574508 0.06073397249571954 4.645137782123422e-06 5.333001399619004 0.3645076203160884 EVSFQSTGES(ph)EWK ddPTM_A459_Selumetinib_30min_R1 1 EVSFQSTGESEWK 13 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 1 EVS(0.1)FQS(0.1)T(0.005)GES(0.795)EWK 177.93 0.00010533 21846000.0 2322.8 3928.8 2394.9 2674.1 2436.7 3657.7 3481.3 3246.9 1973.3 2871.1 True False 2376.916720617985 3468.8142695504316 2069.685734244048 2207.1186340738827 2216.3009152343247 3620.906858925878 3218.7027381892917 3160.781664582413 3348.5459758703214 3239.633651882273 0.733699231466176 1.0707427574519117 0.638864129912199 0.6812864883013904 0.6841208461785864 1.117690223035583 0.9935391109174273 0.9756602147733445 1.0336187160930275 1.0 11.661614962433898 -6.759580300843476 24.99999978873297 1.020670265525859 0.767612974269325 0.55676557519613 0.1169645961844931 42.05564911718518 565546.0337635203 0.04165644732139397 0.03965208960050047 1.7394810390837888e-07 6.759580300843476 -0.2530572912565341 EVSPS(ph)DVR ddPTM_A459_Selumetinib_30min_R1 1 EVSPSDVR 8 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 EVS(0.404)PS(0.596)DVR 106.88 0.013539 17363000.0 6042.2 11248.0 4804.7 5528.1 5955.6 5721.2 7185.9 6421.1 2890.3 5886.6 True False 6182.9715039254315 9931.07893094666 4152.248130327936 4562.721110289006 5416.917031546582 5663.649922433976 6643.861777598717 6250.791569327703 4904.628000840213 6642.202450339657 0.9308616456894141 1.4951484850388477 0.6251312213640231 0.6869289432838178 0.8155302510042556 0.8526764977096353 1.0002498158211024 0.9410721242030287 0.7384038709313067 1.0 12.697445980650839 -5.268448884708597 24.997405599534293 0.8313012817776351 1.2130050705105944 0.43493760175021234 0.1734783709410943 440.9410566313234 1572495.5274197746 0.04468085657436874 0.09632439536747288 5.389532749900745e-06 5.268448884708597 0.3817037887329593 EVSS(ph)RPS(ph)TPGLSVVSGISATSEDIPNKIEDLR ddPTM_A459_Selumetinib_30min_R1 1 EVSSRPSTPGLSVVSGISATSEDIPNKIEDLR 32 2 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 2 EVS(0.257)S(0.732)RPS(0.512)T(0.4)PGLS(0.095)VVS(0.003)GISATSEDIPNKIEDLR 73.60300000000002 9.6044e-05 15663000.0 1132.9 1391.5 1530.4 1451.5 1354.1 1334.9 1414.9 1418.8 817.07 866.66 True False 1159.2943657603385 1228.5825331091999 1322.5800858854614 1198.0227730295192 1231.6218940857723 1321.4721179922233 1308.1729538574743 1381.1688150880923 1386.5081135683195 977.9042529832784 1.1854886224532677 1.256342355973175 1.3524637834948414 1.2250920981013513 1.2594503913123203 1.3513307810665791 1.3377311223124861 1.412376325059003 1.417836264990687 1.0 9.933549406988686 -6.751427194555687 24.08608652998562 1.3317456815698618 1.259467195378836 0.01288187818555342 0.11819479594311612 352.04187480907837 846895.2148843728 0.03725582068127699 0.03680422594501622 1.7724451542315237e-07 6.751427194555687 -0.07227848619102595 EVSSLEGS(ph)PPPCLGQEEAVCTK ddPTM_A459_Selumetinib_30min_R1 2 EVSSLEGSPPPCLGQEEAVCTK 22 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EVSS(0.001)LEGS(0.999)PPPCLGQEEAVCTK;EVS(0.001)S(0.005)LEGS(0.994)PPPCLGQEEAVCTK 152.03 1.049e-07 113195000.0 10134.4 11392.1 12596.3 12575.599999999999 11846.5 10260.7 10809.599999999999 10396.0 6063.8 8752.8 True False 10370.511801890352 10058.307635956397 10885.791646523157 10379.507533248383 10774.98616666945 10157.486673970192 9994.223169141116 10120.264309032846 10289.825717570808 9876.307139491882 1.0500394181163442 1.0184279907351967 1.1022127494389782 1.0509502576873475 1.0909934264381134 1.0284701083620589 1.011939283376246 1.024701253828515 1.0418697568067126 1.0 13.269755987660774 -6.924109730001054 8.969923725668204 1.021476298279027 1.0615840499804738 0.4326309176281361 0.023671683490897513 0.3075204907093656 33.16558280598386 0.008354964385454381 0.007367815064992816 1.1909410636676497e-07 6.924109730001054 0.04010775170144676 EVSSLEGS(ph)PPPCLGQEEAVCTK ddPTM_A459_Selumetinib_30min_R2 4 EVSSLEGSPPPCLGQEEAVCTK 22 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 EVS(0.007)S(0.008)LEGS(0.984)PPPCLGQEEAVCTK;EVS(0.003)S(0.013)LEGS(0.985)PPPCLGQEEAVCTK;EVS(0.002)S(0.008)LEGS(0.989)PPPCLGQEEAVCTK;EVS(0.03)S(0.024)LEGS(0.946)PPPCLGQEEAVCTK 227.6 1.5699e-30 40409300.0 187494.0 168369.0 198903.0 212166.0 228328.0 158153.0 181334.0 170756.0 160562.0 201123.0 True False 177073.83407795028 181282.3609083363 186105.79752921162 183268.62479323527 199643.3953617815 179937.14018000767 189766.39030650418 171252.8716898223 192678.88647711644 195316.05640968925 0.9066015223373411 0.9281487873586989 0.9528443331808909 0.9383182732750673 1.0221555720079427 0.9212613826411525 0.9715862269329039 0.8767987375835977 0.9864979358018515 1.0 17.575451028630596 -10.223931907191002 0.006528848519083989 1.9459660687926514 1.5563087016446538e-06 0.16557698453422176 0.03896183437218542 24578.49315603432 34.38145395494596 5300.817263355148 4949.287013129164 5.971289027789309e-11 10.223931907191002 -1.9459645124839497 EVSSRPS(ph)TPGLSVVSGISATSEDIPNK ddPTM_A459_Selumetinib_30min_R2 1 EVSSRPSTPGLSVVSGISATSEDIPNK 27 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 EVS(0.155)S(0.155)RPS(0.531)T(0.155)PGLS(0.002)VVSGISATSEDIPNK 85.42299999999999 3.4037e-05 3326900.0 15518.0 10709.0 16182.0 13745.0 17840.0 11498.0 13247.0 16125.0 15778.0 11130.0 True False 14655.571683475893 11530.345865137735 15140.867737629445 11872.90728855247 15598.779708376442 13081.745131548108 13863.011748432527 16171.921080362543 18934.040874154223 10808.64798078711 1.3559116468152979 1.0667704125098234 1.4008105143717386 1.0984636847880633 1.4431758473496428 1.210303560149386 1.2825851830011206 1.4962020327712504 1.7517492389252005 1.0 13.399898451798455 -7.72331251634026 6.673255734444471 1.4680359065823732 1.2604489556578222 0.08417331974404618 0.2071607784400887 0.31173748744930296 38.29940945464718 0.0938617400919732 0.05244788814316759 1.890982386583076e-08 7.72331251634026 -0.20758695092455093 EVSSRPS(ph)TPGLSVVSGISATSEDIPNKIEDLR ddPTM_A459_Selumetinib_30min_R2 1 EVSSRPSTPGLSVVSGISATSEDIPNKIEDLR 32 2 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 EVS(0.244)S(0.231)RPS(0.257)T(0.257)PGLS(0.007)VVS(0.001)GIS(0.001)AT(0.001)S(0.001)EDIPNKIEDLR 42.121 0.016738 5910800.0 5164.8 7855.8 4860.0 6507.1 5870.1 1259.1 4809.4 4107.9 1906.4 4148.1 True False 4877.761092332537 8458.314599621728 4547.3128911679105 5620.821754626391 5132.645558640167 1432.5295960281971 5033.046629645309 4119.853308900544 2287.7332692665495 4028.333574941868 1.2108632519100475 2.0997056083529 1.1288322594370879 1.3953218247839627 1.2741361814144787 0.3556134489306461 1.2494115832296584 1.0227190058261242 0.5679105830503531 1.0 11.975967438460732 -6.192738782918387 1.4044366425369896 0.8709091239964061 1.5685797597932318 0.3995488596377834 0.3462218786323203 0.41322671621625817 1.6397176324671523 0.12711882783225253 0.18882663902729507 6.415953638409031e-07 6.192738782918387 0.6976706357968258 EVTLDDISQIKAQVKELS(ph)S(ph)T(ph)AQLK ddPTM_A459_Selumetinib_30min_R2 1 EVTLDDISQIKAQVKELSSTAQLK 24 2 A0A0A0MTS7;Q8WZ42-5;Q8WZ42-11;Q8WZ42-4;Q8WZ42-7;Q8WZ42-2;Q8WZ42;Q8WZ42-8;Q8WZ42-13;Q8WZ42-12;A0A0A0MRA3;Q8WZ42-3;Q8WZ42-10;Q8WZ42-9 A0A0A0MTS7 TTN Titin 3 EVT(0.003)LDDIS(0.019)QIKAQVKELS(0.983)S(0.998)T(0.998)AQLK 54.744 0.041372000000000006 7884500.0 21667.0 19822.0 26221.0 26912.0 34093.0 22379.0 24108.0 23390.0 24353.0 23413.0 True False 20462.834879873215 21342.283662224327 24533.969407266195 23246.539174210542 29809.932544712905 25461.504113664552 25229.069769095724 23458.06102757705 29224.28047967282 22737.005855720436 0.8999793116878202 0.9386584934557155 1.0790325499737539 1.0224098688157708 1.3110755538294847 1.1198266066883498 1.1096038734910343 1.031712846292609 1.285317893882683 1.0 14.4727546636165 -5.335980665441206 1.4423761479915653 1.1372406287929968 0.8856264534885959 0.42217280873467655 0.0968847402956857 0.5082795352670656 1.7662693065128858 0.02900350137178889 0.1361055603023603 4.613381126300196e-06 5.335980665441206 -0.2516141753044009 EVVEEAENGR ddPTM_A459_Selumetinib_30min_R1 2 EVVEEAENGR 10 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ; 202.44 0.0029892 72909000.0 3812.9 4362.6 3650.6 3695.8 4009.6000000000004 3732.5 4222.9 3631.3999999999996 2711.2 3735.9 False True 3901.733151388112 3851.824763882285 3154.8685713104196 3050.39790875818 3646.9323879523763 3694.954438838845 3904.363253123704 3535.083475550392 4600.708381786662 4215.4391557476165 0.9255816552513215 0.9137422274570005 0.7484080435626398 0.7236251778415684 0.8651370007274095 0.8765289456973641 0.92620557642262 0.8386038429069528 1.091394801776167 1.0 12.041467220649427 -8.255305400367808 24.93193974808473 1.0456974081222747 0.8502381408544655 0.5596032021590606 0.0686336117082931 341.0937485464425 1386411.394819318 0.05379077468945066 0.019161849042887667 5.55513477068246e-09 8.255305400367808 -0.19545926726780927 EVVEEAENGR ddPTM_A459_Selumetinib_30min_R2 2 EVVEEAENGR 10 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ; 133.99 0.030151 24251000.0 100352.0 91291.0 123984.0 114356.0 157899.0 102963.0 87184.0 101505.0 122663.0 103113.0 False True 94774.83758088497 98292.7261531694 116007.00442357238 98780.51552489655 138062.31598502988 117145.21864494577 91238.22875181853 101800.36274494263 147199.0274905803 100135.85977025158 0.9464625140117959 0.9815936706259774 1.1584961140767656 0.9864649462393922 1.3787499932770888 1.1698628135187523 0.9111444088177054 1.0166224465292457 1.469993145595483 1.0 16.611599186355114 -5.188299047902567 4.36045007433803 1.1336407607506878 0.9548138562133828 0.146334608870761 0.16681246755180745 0.44205534931915835 15.963029203907574 0.043386565768543044 0.12508323269729146 6.481879484854691e-06 5.188299047902567 -0.178826904537305 EVVETPLLHPER ddPTM_A459_Selumetinib_30min_R2 1 EVVETPLLHPER 12 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 88.101 0.038793 2329600.0 26913.0 25802.0 31127.0 35721.0 30910.0 26456.0 36565.0 30312.0 25815.0 27026.0 False True 25417.28320127509 27780.9304334937 29124.322708515112 30855.738177837964 27026.809461093962 30100.073856343435 38265.34495217297 30400.202901578275 30978.72133136591 26245.68915801908 0.9684364943988953 1.0584949881190506 1.1096802424643706 1.1756497606926177 1.0297618514938565 1.1468578201592659 1.4579668577870595 1.1582931855416656 1.180335602728904 1.0 14.679792859811151 -7.002076325514501 24.971600393949576 1.2252074801626494 1.0773257126626496 0.20512884386668773 0.11686511804312577 111.43199810560239 1340188.2087472316 0.0410253500216251 0.035606320543932805 9.952304942105767e-08 7.002076325514501 -0.1478817674999997 EVVKPVPITS(ph)PAVSK ddPTM_A459_Selumetinib_30min_R1 1 EVVKPVPITSPAVSK 15 1 Q96HC4;A0A0D9SFR4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 EVVKPVPIT(0.028)S(0.972)PAVSK 226.06 5.7159e-13 49958000.0 3444.1 4244.0 4988.8 5025.3 4424.4 3341.4 4579.9 4509.4 2275.8 4079.0 True False 3524.3408289479944 3747.1105070179296 4311.34836151685 4147.725691564072 4024.2138011912652 3307.788549748459 4234.434455701353 4389.796063404456 3861.866382144467 4602.57938282463 0.7657316769157138 0.814132727618118 0.9367243892860248 0.901174177905996 0.8743388144935333 0.7186814771934362 0.9200133454521008 0.9537686801852426 0.8390656762066355 1.0 12.168226889283392 -14.522878745117627 0.11541287985501231 1.4507008482524042 0.7887983544249411 0.3058582758536915 0.0695333569207773 224.15845724552537 1.690798643620957 23.653816082900445 0.8037412240626929 3.000000001123967e-15 14.522878745117627 -0.6619024938274631 EVVKPVPITS(ph)PAVSK ddPTM_A459_Selumetinib_30min_R2 2 EVVKPVPITSPAVSK 15 1 Q96HC4;A0A0D9SFR4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 EVVKPVPIT(0.098)S(0.897)PAVS(0.004)K;EVVKPVPIT(0.067)S(0.933)PAVSK 128.74 0.00051891 382210000.0 488410.0 439880.0 545990.0 522960.0 522860.0 337770.0 419480.0 406340.0 318430.0 423630.0 True False 461266.12746014073 473617.38156287017 510861.59782896517 451731.94584368117 457173.65237229364 384294.7515292232 438986.6511838508 407522.3821267915 382124.89767758397 411398.7011770756 1.1212143503136658 1.1512369392702924 1.2417676486758726 1.0980393096798942 1.1112666400361713 0.934117561454852 1.0670589137200523 0.9905777071264606 0.9288432281975253 1.0 18.650177713588064 -6.493045241770972 2.1019711386966256 0.988442155784198 1.1631726371282813 0.7023033510358931 0.051907886285928954 0.1788472543116246 1.5804593951438803 0.01867093184874862 0.020568069762145022 3.213325779329655e-07 6.493045241770972 0.1747304813440833 EVVKPVPITSPAVS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 EVVKPVPITSPAVSK 15 1 Q96HC4;A0A0D9SFR4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 EVVKPVPIT(0.301)S(0.176)PAVS(0.523)K 114.03 0.0014389 226690000.0 3610.9 4707.7 4181.3 4571.2 3697.3 3510.9 4301.5 4080.4 2000.1 3220.5 True False 3695.0269444116925 4156.520295449647 3613.502426236854 3772.9257320513543 3362.879867811334 3475.5835336421437 3977.034391842481 3972.1745369928485 3394.0236184757678 3633.88254532648 1.0168261902586395 1.1438235120712223 0.9943916406665821 1.0382629831841146 0.9254233800529186 0.9564380494664243 1.0944311881949313 1.0930938156219288 0.9339937590555332 1.0 11.827296074070798 -5.29141112040707 24.6325914913016 1.007705489133337 1.0803248919454411 0.18993595559385967 0.062353176398413535 884.9847316092091 727332.4837937193 0.016875906510649314 0.03513694030222074 5.111976863839674e-06 5.29141112040707 0.0726194028121041 EVVYWS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 EVVYWSPK 8 0 E6ZCI6;C0MHM2;Q86VZ5 E6ZCI6 SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 1 EVVYWS(1)PK 96.342 0.021197 0.0 19065.0 13557.0 16988.0 18252.0 16017.0 14096.0 18214.0 16112.0 12249.0 15928.0 True False 18005.44362324193 14596.778307374392 15895.010575135895 15766.046113543814 14004.801266203229 16037.596049252234 19060.987090356306 16158.883252514803 14699.142265655657 15468.11725408598 1.1640358892731888 0.9436687133670764 1.0275982728885216 1.019260835340457 0.9053979250450659 1.03681629676138 1.2322758340431672 1.044657406398077 0.9502864520743664 1.0 13.917009985289635 -7.001646323355928 24.995237959555034 1.071100613724926 1.0056313502380474 0.03873583777431844 0.09272241812070824 160.75617181214216 2440725.183568196 0.033190749823864364 0.028858354441842305 9.962163763927935e-08 7.001646323355928 -0.06546926348687854 EVYELLDS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 4 EVYELLDSPGK 11 0 E9PBS1;P22234;P22234-2 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 EVYELLDS(1)PGK;EVYELLDS(1)PGK;EVYELLDS(1)PGK;EVYELLDS(1)PGK 198.52 1.9714e-05 55588000.0 14861.820000000002 18578.1 12239.990000000002 13060.809999999998 10400.48 12543.380000000001 15466.630000000001 14067.5 8755.48 16132.85 True False 15208.071489932321 16402.96741527562 10577.86658745242 10779.984715268118 9459.75842035388 12417.204985677812 14299.969646844753 13694.384202320092 14857.410085041858 18203.658444766446 0.8354403888689004 0.9010808165317711 0.5810846550185387 0.5921878147723303 0.5196624870246103 0.6821268935227556 0.7855547108969184 0.7522874725358972 0.8161771508799851 1.0 14.151940801935865 -8.569876193885348 0.9483063971886436 0.9969014574868107 0.6866478803505279 0.41235026104980677 0.11089126766412656 0.7172950792511171 1.4107824796859503 0.11978156880748748 0.04054476946979344 2.6923022002037095e-09 8.569876193885348 -0.31025357713628277 EVYELLDS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 6 EVYELLDSPGK 11 0 E9PBS1;P22234;P22234-2 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 EVYELLDS(1)PGK;EVYELLDS(1)PGK;EVYELLDS(1)PGK;EVYELLDS(1)PGK;EVYELLDS(1)PGK;EVYELLDS(1)PGK 165.58 4.9771e-05 3517900.0 68235.1 64758.5 75211.3 71863.7 72660.4 64090.2 71710.4 78555.0 61718.1 66763.1 True False 64442.866308747674 69725.26871860314 70372.28684187171 62075.74008820286 63532.150959782266 72918.04329709032 75045.07569146183 78783.58204451973 74063.44454779681 64835.4758316342 0.993944526235821 1.0754184776813673 1.0853978618837563 0.9574347884698515 0.979897967044517 1.1246627307316301 1.1574693441957622 1.2151307757670538 1.1423290042649792 1.0 15.984495803795026 -6.865606780110063 5.833368517188657 1.1456128630367501 1.0222694788879367 0.4178972422444308 0.06317958827609241 0.19307851054519104 9.351937834066113 0.02262798811588333 0.01998534412948664 1.3626779230003712e-07 6.865606780110063 -0.1233433841488134 EVYELLDS(ph)PGKVLLQSK ddPTM_A459_Selumetinib_30min_R1 2 EVYELLDSPGKVLLQSK 17 1 E9PBS1;P22234;P22234-2 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 EVYELLDS(1)PGKVLLQSK;EVYELLDS(1)PGKVLLQSK 100.28 0.0024467 89523000.0 7865.8 7644.3 13483.0 13447.5 8560.5 8276.2 7845.9 8334.7 5167.6 7446.5 True False 8049.0578358175235 6749.301802261346 11652.082656817614 11099.14656583842 7786.20428647903 8192.948942188363 7254.077446229668 8113.636681078889 8769.039773429022 8402.330810052365 0.9579553599803291 0.8032654218025586 1.3867679005065259 1.32096043547341 0.9266719512118929 0.97508050175631 0.8633410907305683 0.9656411851068648 1.043643718828344 1.0 13.036573872274994 EVYMT(ph)PLR ddPTM_A459_Selumetinib_30min_R1 1 EVYMTPLR 8 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 1 EVYMT(1)PLR 119.75 0.018067 3450700.0 1801.3 2778.7 1701.6 2027.7 2019.3 2036.9 2710.7 2195.3 1054.5 1962.6 True False 1843.2667852803397 2453.368512217417 1470.5320662197478 1673.6002596430992 1836.6546715363704 2016.410635357226 2506.2297166029107 2137.0735126606214 1789.409482367231 2214.5188273428826 0.832355436549621 1.1078562448534797 0.6640413475211604 0.7557399101687425 0.8293696350010729 0.9105412022062783 1.1317265338448448 0.9650283782977881 0.8080353439642127 1.0 11.112777547407442 -6.998598207681437 9.223364770816502 0.9800982933718649 0.8416235204330585 0.20655578434066624 0.12776927593737145 0.1780184084655728 228.6008344140861 0.04827754024710164 0.041020607103431465 1.003232960877782e-07 6.998598207681437 -0.1384747729388064 EVYMT(ph)PLR ddPTM_A459_Selumetinib_30min_R2 3 EVYMTPLR 8 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 1 EVYMT(1)PLR;EVYMT(1)PLR;EVYMT(1)PLR 109.83 0.028726 26303800.0 63010.0 47302.0 59477.0 64781.0 76917.0 70025.0 71426.0 69847.0 63102.0 60740.0 True False 59508.15644901514 50929.911300097614 55650.31457366127 55957.71604654186 67253.99881329555 79670.30812633997 74747.4505279339 70050.24320620662 75724.16321719355 58986.27837852733 1.008847448675077 0.8634196409759857 0.9434450876276941 0.9486564940993472 1.140163452620498 1.3506583279433038 1.2672006538243323 1.1875684503551742 1.2837589571468757 1.0 15.848091767623956 -6.3558884818845565 3.3081169750861794 1.2336298718679923 0.9331625317842265 0.6633180092105501 0.09275249083198375 0.1367327903119557 2.8532326666162233 0.028664811695175586 0.03336964692197351 4.406680036879167e-07 6.3558884818845565 -0.30046734008376585 EVYQQQQYGS(ph)GGR ddPTM_A459_Selumetinib_30min_R1 3 EVYQQQQYGSGGR 13 0 Q99729-3;Q99729-4;D6R9P3;D6RD18;D6RBZ0;Q99729-2;Q99729 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 EVYQQQQYGS(1)GGR;EVYQQQQYGS(1)GGR;EVYQQQQYGS(1)GGR 184.0 0.00012206 15662700.0 3537.99 4257.5 4110.950000000001 4355.96 3813.7 3719.5099999999998 3891.24 4016.6000000000004 1892.9199999999998 3418.66 True False 3620.418283269856 3759.029920741947 3552.7055698319646 3595.273357496156 3468.7515083634207 3682.095106444868 3597.720633944702 3910.066720244453 3212.146986593243 3857.478311568335 0.9385453373548335 0.9744785627099581 0.9209917160590699 0.9320268494353312 0.8992277410765611 0.9545342342956269 0.932661273338949 1.0136328462349118 0.8327064281762042 1.0 11.913442330017846 EVYQQQQYGS(ph)GGR ddPTM_A459_Selumetinib_30min_R2 4 EVYQQQQYGSGGR 13 0 Q99729-3;Q99729-4;D6R9P3;D6RD18;D6RBZ0;Q99729-2;Q99729 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 EVYQQQQY(0.004)GS(0.996)GGR;EVYQQQQYGS(1)GGR;EVYQQQQYGS(1)GGR;EVYQQQQYGS(1)GGR 215.93 2.1633e-08 30923300.0 61448.1 54270.2 64310.9 63720.0 67300.2 50635.7 44243.1 50913.7 46830.2 51281.5 True False 58033.060598234 58432.54983380318 60173.20671041363 55041.22607686893 58845.34720457824 57610.30804988084 46300.49181603948 51061.85043778324 56197.54854511455 49800.86984966165 1.1653021478023096 1.1733238798880172 1.2082762187099119 1.1052261987195569 1.1816128389367488 1.1568132890809788 0.9297125121671755 1.025320453074981 1.1284451198294956 1.0 15.603883320976008 -7.158424996490884 8.123725610088872 1.0232249291927158 1.1661273713421325 0.6561575873158141 0.0511585299082012 0.19146114149369775 13.55446768599773 0.019690879524086425 0.015242978669451785 6.943445060184694e-08 7.158424996490884 0.14290244214941672 EWNGVVSESDS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 4 EWNGVVSESDSPVK 14 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 EWNGVVS(0.009)ES(0.022)DS(0.969)PVK;EWNGVVS(0.008)ES(0.036)DS(0.956)PVK;EWNGVVSES(0.001)DS(0.999)PVK;EWNGVVSESDS(1)PVK 236.27 2.5739999999999997e-19 203455000.0 7690.7 11075.2 6139.099999999999 6748.5 6951.0 7110.799999999999 9150.6 8770.7 4310.76 8149.299999999999 True False 7869.878346502816 9778.51043527921 5305.44393966246 5570.001160034249 6322.283277298721 7039.271808089821 8460.36287480968 8538.072544751292 7315.044874546574 9195.342035904077 0.8558548791088071 1.0634199790609307 0.576970809671555 0.6057415959390804 0.687552812349206 0.7655258260763246 0.9200704924053285 0.9285214743957958 0.7955163435992151 1.0 13.166687523717473 -7.239395797177852 7.481133466377505 0.9051600604100062 0.7542324875271096 0.22868216652104567 0.1362865071181116 0.35105032878536224 93.86204864884772 0.05839348660853932 0.043999197112799586 5.762410628721349e-08 7.239395797177852 -0.1509275728828966 EWNGVVSESDS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 4 EWNGVVSESDSPVK 14 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 EWNGVVSES(0.002)DS(0.998)PVK;EWNGVVS(0.002)ES(0.005)DS(0.993)PVK;EWNGVVSESDS(1)PVK;EWNGVVSES(0.002)DS(0.997)PVK 208.49 5.9416e-06 28723200.0 134544.0 102143.4 124001.0 112350.2 124281.9 120299.5 143176.7 137611.9 114758.3 116017.0 True False 127066.58310230587 109977.4703372035 116022.91066208085 97047.90894509462 108668.496627717 136869.6641548678 149834.7002492488 138012.32784612366 137713.16661480893 112667.28776163346 1.1278036919743426 0.976126012457842 1.0297834710244091 0.8613672244459789 0.9645079666568652 1.2148128074622557 1.3298864579597338 1.22495473697842 1.222299474415007 1.0 16.78170917331328 -6.765524429133528 24.777556820208662 1.2206689025397017 0.9858911969027673 0.5126074546017836 0.09939973567235962 67.89063542209634 411782.1871788195 0.0338308522414079 0.03091879419722039 1.7158351914046105e-07 6.765524429133528 -0.23477770563693445 EWNGVVSESDS(ph)PVKRPGR ddPTM_A459_Selumetinib_30min_R1 1 EWNGVVSESDSPVKRPGR 18 2 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 EWNGVVS(0.001)ES(0.271)DS(0.728)PVKRPGR 79.029 0.014061 68863000.0 2001.4 2536.7 2520.8 2349.1 2014.7 2332.1 2311.5 2469.7 1302.6 1905.1 True False 2048.02872595352 2239.701984720165 2178.489205763246 1938.873783068304 1832.4707407241758 2308.64119137738 2137.1416940006743 2404.1955332838047 2210.417061860175 2149.6381422454524 0.9527318508659349 1.041897210839697 1.0134213582048077 0.9019535637021262 0.8524554457384291 1.073967355717757 0.9941867200813042 1.1184187171020554 1.0282740236229875 1.0 11.06987810990705 -6.80984314868844 24.99993057286471 1.0473216931653655 0.9580352988804939 0.3621288564639542 0.059675098495696306 142.33893444085075 73515.21060317368 0.022467333781425625 0.01981436563314968 1.549376095956008e-07 6.80984314868844 -0.08928639428487162 EWNGVVSESDS(ph)PVKRPGR ddPTM_A459_Selumetinib_30min_R2 4 EWNGVVSESDSPVKRPGR 18 2 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 EWNGVVS(0.001)ES(0.019)DS(0.979)PVKRPGR;EWNGVVS(0.001)ES(0.033)DS(0.967)PVKRPGR;EWNGVVSES(0.017)DS(0.983)PVKRPGR;EWNGVVS(0.002)ES(0.092)DS(0.906)PVKRPGR 63.374 0.015048 426581000.0 1398830.0 1175840.0 1453330.0 1463450.0 1488560.0 1161130.0 1236350.0 1113300.0 844800.0 1370330.0 True False 1321088.6285601608 1266023.147078492 1359824.3300660627 1264125.5854079404 1301553.7849047561 1321065.1178113117 1293842.724781048 1116539.5186832629 1013783.6056842098 1330765.0123550761 0.9927287058909139 0.9513498892174739 1.0218365507367524 0.9499239713033912 0.978049297074151 0.9927110387982034 0.9722548404630159 0.8390207950442768 0.7618051243247678 1.0 20.343824410716678 -7.74795980074404 9.718066831965166 0.8502449781393686 0.9797080360569717 0.4309707753868208 0.05851145652802524 0.16093841249846266 105.363015239113 0.026690055904780494 0.014767938579559246 1.7866529437390287e-08 7.74795980074404 0.12946305791760304 EWQELDDAEK ddPTM_A459_Selumetinib_30min_R1 1 EWQELDDAEK 10 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 144.17 0.013985 3497000.0 1305.4 1249.5 1575.4 1083.0 1381.1 1272.3 1139.7 970.44 596.02 1003.6 False True 1335.8132801337688 1103.2079591232098 1361.469333052768 893.8743804278122 1256.1797488530094 1259.5018171559723 1053.7315114222654 944.7007787666251 1011.4024084215422 1132.4218358918356 1.179607490597135 0.9742023017901111 1.2022634056509045 0.789347531190834 1.1092860531638447 1.1122196492829504 0.9305114737498876 0.8342304509013894 0.8931322024756041 1.0 10.14519575801268 -7.404900700644674 5.38019994987765 0.8950880912666034 1.0529112625621708 0.27259539649010933 0.1164465484045128 0.2975000972368249 11.932333703590645 0.048534456833726466 0.032115191236151086 3.936400690854324e-08 7.404900700644674 0.15782317129556744 EWSLESS(ph)PAQNWTPPQPR ddPTM_A459_Selumetinib_30min_R1 1 EWSLESSPAQNWTPPQPR 18 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;E5RHT6;E5RHC5;F8W1U7;Q8N6T3-3 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 EWSLES(0.019)S(0.727)PAQNWT(0.254)PPQPR 132.84 0.00046449 12587000.0 410.73 411.65 401.33 494.37 402.79 446.86 476.81 408.01 163.34 361.04 True False 420.2992098585433 363.45382662910697 346.83159034789065 408.03755997423633 366.3577156183503 442.3649941164169 440.84383781806645 397.18824939673857 277.17605011841005 407.3830008274093 1.0317053215399286 0.8921673852146981 0.8513649063497087 1.0016067414337309 0.899295539760532 1.085870036839922 1.0821360658709298 0.9749750200426507 0.6803819736107193 1.0 8.67024197092863 -11.994205852934407 2.253176091917407 1.5817708682737164 0.9495860321449747 0.018579613024581665 0.11583670787870903 28033678.349757146 3137792.2220817823 82959291.211807 0.02939629882673538 1.0134309118064634e-12 11.994205852934407 -0.6321848361287417 EWSLESSPAQNWT(ph)PPQPR ddPTM_A459_Selumetinib_30min_R1 3 EWSLESSPAQNWTPPQPR 18 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;E5RHT6;E5RHC5;F8W1U7;Q8N6T3-3 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 EWSLESS(0.001)PAQNWT(0.999)PPQPR;EWSLES(0.029)S(0.147)PAQNWT(0.825)PPQPR;EWS(0.255)LESSPAQNWT(0.744)PPQPR 254.59 4.1201e-33 23924500.0 2052.04 2475.29 2473.59 2726.59 2707.27 2166.2 2604.17 2306.42 1223.13 2243.98 True False 2099.8485394252307 2185.4818960688995 2137.6900644572784 2250.4422409332137 2462.39790650734 2144.409994752233 2407.7353602707035 2245.2462492919917 2075.5622761193267 2532.016691216183 0.8293186007461221 0.8631388188121164 0.8442638122699337 0.8887943941049918 0.9725046106724503 0.84691779568097 0.9509160696386308 0.8867422782325937 0.819726932811959 1.0 11.30607119979779 -5.866865706090449 4.54180561843127 0.9076478852033448 0.847438390079495 0.245097934617035 0.05207255308675564 0.3289477325188302 11.62825802062054 0.014402081794854579 0.022100060733380514 1.3587335335024697e-06 5.866865706090449 -0.06020949512384988 EWSLESSPAQNWT(ph)PPQPR ddPTM_A459_Selumetinib_30min_R2 2 EWSLESSPAQNWTPPQPR 18 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;E5RHT6;E5RHC5;F8W1U7;Q8N6T3-3 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 EWS(0.088)LES(0.02)S(0.008)PAQNWT(0.883)PPQPR;EWSLESS(0.175)PAQNWT(0.825)PPQPR 189.56 5.1163e-10 20147200.0 25397.0 23771.0 28211.0 27120.0 27962.0 23559.0 22459.2 17663.3 18776.8 24872.0 True False 23985.536412246263 25594.15926418799 26395.934973814365 23426.20921539053 24449.163576548344 26804.038402691065 23503.59730206052 17714.69727868327 22532.684667627007 24153.88073478318 0.9930303405740308 1.0596292804961447 1.0928237687206297 0.9698735152589888 1.012225068302997 1.1097197463632205 0.9730774760435822 0.733409983811543 0.9328805136964371 1.0 14.559967380910196 -7.5306584915731465 24.900421435459968 0.870535851992383 1.0387189240774921 0.44666489351666416 0.07442182579274648 138.50443690363304 443299.6788245866 0.03307886585932046 0.01914264049481406 2.9467378968458604e-08 7.5306584915731465 0.16818307208510908 EWSQHINGASHSR ddPTM_A459_Selumetinib_30min_R2 1 EWSQHINGASHSR 13 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991;H0Y8T4 D6REM6 MATR3 Matrin-3 0 85.271 0.015808000000000003 1890700.0 4509.2 3786.4 6393.9 11107.0 11788.0 8655.0 5471.5 5514.8 8117.1 8194.3 False True 4258.596715757801 4076.804704805075 5982.52343515195 9594.207439356298 10307.086053942918 9847.147687732553 5725.935591571567 5530.847154975714 9740.746810723618 7957.709267651735 0.5351535941466335 0.5123088275387713 0.7517896462328727 1.2056494044532344 1.295232799700468 1.2374349648285627 0.719545713343364 0.6950300606556123 1.2240641726281671 1.0 12.958137476257322 -5.54013531846798 4.16317556794623 1.0440485132247337 0.5386424340237705 0.5425298759096062 0.19781410412660194 0.17503546082584678 7.046005084582411 0.06113790353057113 0.11857923396264676 2.8831330299759965e-06 5.54013531846798 -0.5054060792009631 EWYQETHEK ddPTM_A459_Selumetinib_30min_R1 2 EWYQETHEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 ; 160.53 0.0012774 29765000.0 12299.9 13523.599999999999 14842.0 15680.6 14622.7 12827.4 12538.8 12259.4 7065.5 10357.1 False True 12586.463738560848 11940.250625048928 12826.53792127027 12942.277571317045 13300.079366847374 12698.368002347337 11592.988220954205 11934.240887856604 11989.63745629745 11686.534671697216 1.07700563872395 1.0217101100094426 1.0975484419974337 1.1074521177489014 1.1380687038954231 1.0865811259774558 0.9919953644625241 1.0211958654227322 1.0259360702821767 1.0 13.512559580325352 -7.25101202106399 23.98633925806726 1.0115481477123065 1.0886308160287308 0.6386875978291169 0.028829428553211262 299.9569337695196 690000.4398596388 0.012436421529678799 0.009519591348893184 5.6103244670718e-08 7.25101202106399 0.0770826683164243 EWYQETHEK ddPTM_A459_Selumetinib_30min_R2 2 EWYQETHEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 ; 140.49 0.0032163000000000005 17191700.0 127160.0 125755.0 141147.0 146576.0 139565.0 116786.0 127629.0 115220.0 88110.0 132558.0 False True 120092.95626181192 135400.00413394303 132065.75568923412 126612.09594229668 122031.59697306935 132872.21142224548 133564.0013920657 115555.27112430226 105734.46199909542 128730.7061129541 0.9329006255619928 1.0518081367093333 1.0259071800115327 0.9835423090991325 0.9479602859165035 1.0321718526553987 1.0375457839473874 0.8976511868342343 0.8213616253011093 1.0 16.973996694841432 -7.774140706880759 24.77148580896096 0.894629728142936 1.002957623163571 0.38557856000940804 0.0545460836803355 189.3656889392376 369315.0503216691 0.028621751100393302 0.013895823799127887 1.6821289805364738e-08 7.774140706880759 0.10832789502063511 EWYQSTIPQS(ph)PSPAPDDPEEGR ddPTM_A459_Selumetinib_30min_R1 1 EWYQSTIPQSPSPAPDDPEEGR 22 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;Q08499-3;Q08499-5;Q08499-8;Q08499-6;Q08499-9;Q08499-4 A0A1B0GW84;Q08499-6;Q08499-9;Q08499-4 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 EWYQSTIPQS(0.561)PS(0.439)PAPDDPEEGR 121.97 3.9304e-05 0.0 525.61 715.86 514.46 478.18 665.64 595.26 727.06 857.36 311.98 897.62 True False 537.8556903409758 632.0467784057149 444.5991577264992 394.67483955029684 605.4329795282866 589.2722248528363 672.2172788406355 834.6200277022317 529.4072738823407 1012.838270559216 0.531038079795317 0.6240352450907531 0.4389636239564918 0.3896721234006945 0.5977587904473736 0.5818028820410616 0.6636965627982103 0.8240407693534476 0.5226967515653218 1.0 9.984188108465604 -9.319393730319703 0.2879754733757662 1.1111137311760444 0.4756199104467957 0.6316303757296937 0.1038993530996416 3.1931935190952516 0.46166005739977095 0.590374376284902 0.15248300290269276 4.792987205518855e-10 9.319393730319703 -0.6354938207292486 EYAENIGDGRS(ph)PEFR ddPTM_A459_Selumetinib_30min_R1 2 EYAENIGDGRSPEFR 15 1 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 1 EYAENIGDGRS(1)PEFR;EYAENIGDGRS(1)PEFR 179.55 9.4919e-05 12519800.0 3095.0 4891.0 3028.8999999999996 3684.8999999999996 3465.0 3140.3 3428.4 3299.3999999999996 1941.38 3395.3 True False 3167.1074781783464 4318.359446235788 2617.5920165567654 3041.4013891398413 3151.591361795436 3108.7114331642665 3169.793027779324 3211.889194038377 3294.3800672148823 3831.119828022668 0.8266793053593852 1.1271794253599725 0.6832446214316839 0.7938674658238453 0.822629284196012 0.8114367528850556 0.8273802882890586 0.8383682417201002 0.8599000331752061 1.0 11.903550435088583 -10.75604663632712 14.778590024720645 0.999999999865107 0.8434165349310786 0.16594205755059732 0.10531896002128607 0.0 0.0 0.10219519799856802 0.024785976222294503 1.7536921730541255e-11 10.75604663632712 -0.15658346493402842 EYAENIGDGRS(ph)PEFR ddPTM_A459_Selumetinib_30min_R2 2 EYAENIGDGRSPEFR 15 1 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 1 EYAENIGDGRS(1)PEFR;EYAENIGDGRS(1)PEFR 83.964 0.012366 40763000.0 118088.0 124470.0 114148.0 124035.0 133702.0 93804.0 92207.0 112193.0 90350.0 122069.0 True False 111525.14170371846 134016.44876586946 106803.84195494524 107141.21902769023 116905.1594489545 106724.64953206985 96494.80820470424 112519.46305544904 108422.52458992485 118544.55079664853 0.9407867418134539 1.1305154717382282 0.9009595231260918 0.9038055170623609 0.9861706730787968 0.9002914837911482 0.8139961521321343 0.949174485872953 0.9146141586542682 1.0 16.85506982161492 -5.28960757601799 24.771146912347795 0.9164455003741254 1.0356511379594397 0.3309364164412508 0.0648632433986293 581.7542839299551 511594.5292573344 0.01636948367997545 0.03408750528576888 5.133250096419946e-06 5.28960757601799 0.11920563758531433 EYCLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 EYCLSPR 7 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 EYCLS(1)PR;EYCLS(1)PR 101.43 0.019928 71503000.0 6884.8 7911.1 8916.599999999999 9361.3 7881.9 6828.4 8124.4 6251.6 3973.7 6207.0 True False 7045.20244451124 6984.864734229386 7705.77469537788 7726.524688364617 7168.983536662465 6759.712495691139 7511.569967008031 6085.787259941298 6743.078672434954 7003.728911299946 1.0059216359937033 0.9973065523652516 1.10023885746709 1.1032015639409598 1.0235952344037609 0.9651590718745401 1.072510095998822 0.8689352967563287 0.9627840765732016 1.0 12.773907528072035 -7.749438642284341 24.9904323425048 0.9368947510774123 1.0382038621782006 0.40923485543934046 0.05175392232190074 203.00036952543414 422731.66679429647 0.025431830572153463 0.014538455642008776 1.780579453773346e-08 7.749438642284341 0.10130911110078833 EYCLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 EYCLSPR 7 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 EYCLS(1)PR;EYCLS(1)PR 104.06 0.018235 22772000.0 62182.0 62498.0 68947.0 73913.0 70977.0 56660.0 58146.0 64517.0 57368.0 62465.0 True False 58726.17337426849 67291.39563725625 64511.02508381762 63845.92189296308 62060.234717569256 64464.40069173038 60849.90421411318 64704.73378863568 68843.20299584743 60661.47314643902 0.9680967231458648 1.1092937930276168 1.0634595854288873 1.0524954074035868 1.0230584833928047 1.0626909856954998 1.0031062725301656 1.0666528594258844 1.1348752251640413 1.0 15.888492913371337 -7.988656347600954 24.94534766580314 1.07854643221368 1.0438343244445811 0.0504059918441091 0.04719083585911654 488.57121617206394 1074395.4784646265 0.024436823032709016 0.01172740524673213 1.0264638344114935e-08 7.988656347600954 -0.03471210776909883 EYDS(ph)GDTDEIIAMK ddPTM_A459_Selumetinib_30min_R1 1 EYDSGDTDEIIAMK 14 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 EYDS(0.995)GDT(0.005)DEIIAMK 89.992 0.018814 4934200.0 1202.1 1420.2 969.95 804.34 1239.0 878.73 1298.3 1308.9 474.52 1185.9 True False 1230.1065911205776 1253.9223237669323 838.2361175539752 663.87711833177 1126.9326687632172 869.8907740230036 1200.368185732673 1274.1837200936027 805.2257824304393 1338.121816644208 0.9192784810918673 0.9370763619350932 0.6264273604447577 0.49612607019341926 0.8421749460668545 0.6500833954000902 0.897054491453552 0.9522180299616132 0.6017582049815275 1.0 10.385993743144276 -7.278771402877644 24.56758960605463 0.8587758553294347 0.7416047483494677 0.1134962616987224 0.16062138074761093 1690.5244766896203 2396253.148740984 0.06990014920053227 0.04725946922402804 5.2629421599652164e-08 7.278771402877644 -0.11717110697996702 EYDS(ph)GDTDEIIAMK ddPTM_A459_Selumetinib_30min_R2 3 EYDSGDTDEIIAMK 14 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 EYDS(0.851)GDT(0.149)DEIIAMK;EYDS(1)GDTDEIIAMK;EYDS(0.863)GDT(0.137)DEIIAMK 158.89 3.3849e-05 0.0 26862.9 23104.4 32027.1 32550.0 35976.0 28202.7 29649.699999999997 34250.0 26349.8 26178.600000000002 True False 25369.967558708908 24876.43318764482 29966.511254469915 28116.633848118065 31456.37325047932 32087.365926379534 31028.469799765953 34349.66182960728 31620.496274926427 25422.7557978287 0.9979235831260944 0.9785104882205359 1.1787278882263932 1.105963258732141 1.2373313696057269 1.2621513647674671 1.2204998563694667 1.351138409335663 1.2437871223082377 1.0 14.633832804871416 -5.423381090269386 1.0003054901032495 1.2384689579614647 0.94492449723982 0.44614611867887377 0.0916470927983157 0.6836350556361726 1.0443538493673645 0.03181781408215158 0.17334861606177668 3.7724101937802225e-06 5.423381090269386 -0.29354446072164475 EYFDDST(ph)EER ddPTM_A459_Selumetinib_30min_R2 1 EYFDDSTEER 10 0 Q8NEF9 Q8NEF9 SRFBP1 Serum response factor-binding protein 1 1 EYFDDS(0.094)T(0.906)EER 124.6 0.008866200000000001 12857000.0 15584.0 12106.0 16415.0 22147.0 24453.0 12644.0 17542.0 21773.0 19142.0 19293.0 True False 14717.903667694829 13034.491273074751 15358.876771300664 19130.540394294032 21380.995527406365 14385.596229195875 18357.737758813553 21836.355825285802 22970.93487216758 18735.960960766006 0.785543036651006 0.6956937677426632 0.8197538841729486 1.02106000510752 1.1411742142385537 0.7678066931992439 0.97981298089036 1.1654782944420183 1.226034518339882 1.0 14.193522354429057 -5.3411430027600115 0.4799431504216981 1.0986282137768235 0.5623773782957059 0.4885704865049144 0.125596778688243 2.660474210844429 0.6982303134325676 0.09972533624319427 0.7626908818644768 4.558867786487245e-06 5.3411430027600115 -0.5362508354811176 EYFESWGES(ph)GEK ddPTM_A459_Selumetinib_30min_R2 1 EYFESWGESGEK 12 0 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 EYFESWGES(1)GEK 80.737 0.039572 4714000.0 3289.9 6091.4 20675.0 25718.0 37551.0 20668.0 7717.1 13315.0 27340.0 21978.0 True False 3107.0605285131687 6558.590793061911 19344.79300923796 22215.16403397544 32833.507669800674 23514.829394576132 8075.960441143551 13353.744445583096 32808.76394342607 21343.438034298208 0.14557450976362027 0.3072883938624354 0.906357868781567 1.0408428107166428 1.538342024234254 1.1017357820604425 0.3783814223446919 0.6256604219115994 1.537182711178183 1.0 14.381504965998849 -5.243681319664483 2.9436570293853292 1.0123443742720066 0.16712068699768734 0.47815470724663345 0.33373605688810865 0.2516008290832677 4.332469878028768 0.09727973356466883 0.3005472877702553 5.705828058569698e-06 5.243681319664483 -0.8452236872743193 EYGS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 EYGSPLK 7 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 EYGS(1)PLK 87.149 0.03397 98640000.0 5008.1 7028.4 4285.1 4921.5 4877.7 5232.6 5645.4 6147.6 3334.7 6329.6 True False 5124.7789859337545 6205.511660585483 3703.2069563694417 4062.0524129967516 4436.512896227878 5179.9647948206675 5219.562932862387 5984.545677780909 5658.742343148411 7142.06581552507 0.7175485522401324 0.8688678907293528 0.5185064170536756 0.568750347296837 0.6211806234806748 0.7252754215118986 0.7308197750735311 0.8379292255711224 0.7923117049478481 1.0 12.802125713362617 -8.306965327055025 0.7446463155361237 0.9888465672362178 0.6615574358139468 0.5373006251918526 0.0937142980307314 0.5433172129373769 0.6749802633296079 0.09801868952428965 0.03923051968278871 4.932131792440538e-09 8.306965327055025 -0.327289131422271 EYGS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 5 EYGSPLK 7 0 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 EY(0.002)GS(0.998)PLK;EYGS(1)PLK;EY(0.002)GS(0.998)PLK;EYGS(1)PLK;EYGS(1)PLK 98.033 0.022118 569802000.0 745910.0 595328.0 729000.0 730170.0 741740.0 593654.0 727550.0 742950.0 534702.0 597242.0 True False 704455.3083143133 640987.7433187708 682096.9336751876 630719.5863864925 648555.9899602667 675424.4498455438 761382.5166129742 745111.8614980057 641657.340822159 579998.0716389257 1.214582155978042 1.1051549559596017 1.1760331060200886 1.0874511782500256 1.118203700449579 1.1645287853060746 1.3127328414411839 1.2846798945253572 1.1063094382520962 1.0 19.1456885780536 -7.007435096084791 24.507165552714273 1.2052219989485147 1.1377823394035396 0.0 0.09006349424203125 617.646209625164 2035853.361535681 0.03158515017125801 0.026706812677058184 9.830257720667622e-08 7.007435096084791 -0.0674396595449751 EYGS(ph)TSSIDK ddPTM_A459_Selumetinib_30min_R1 2 EYGSTSSIDK 10 0 O43166-3;O43166-2;O43166 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 EYGS(0.936)T(0.021)S(0.033)S(0.01)IDK;EYGS(0.974)T(0.011)S(0.011)S(0.004)IDK 109.39 0.010099 25242300.0 4467.8 6096.6 4451.799999999999 5539.4 5235.799999999999 5246.3 6185.200000000001 5423.2 2399.3 4991.1 True False 4571.891047174542 5382.807237767555 3847.2700119869933 4572.0477774162755 4762.222814455571 5193.5269852592755 5718.645384266914 5279.359118963731 4071.436862061353 5631.7563024309875 0.8118055543704995 0.9557954834522986 0.6831385815338444 0.8118333840977314 0.8456017197334913 0.9221860297856732 1.0154284164956535 0.9374267698133277 0.7229426565037782 1.0 12.459369191634279 -6.661495716366088 3.769323136336968 0.9218521049449779 0.8174894304767975 0.21106299406080986 0.0959050809255799 0.3907080934229527 10.573774642133477 0.0337631754414887 0.0333005651672854 2.180239901727012e-07 6.661495716366088 -0.10436267446818048 EYGS(ph)TSSIDK ddPTM_A459_Selumetinib_30min_R2 3 EYGSTSSIDK 10 0 O43166-3;O43166-2;O43166 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 EYGS(0.468)T(0.468)S(0.053)S(0.012)IDK;EYGS(0.843)T(0.121)S(0.018)S(0.018)IDK;EYGS(0.436)T(0.169)S(0.137)S(0.257)IDK 199.03 0.00019075 36551200.0 164152.0 130121.0 165786.0 167866.0 160766.0 119133.0 121685.0 140852.0 103926.0 133472.0 True False 155029.08899252056 140100.86229504013 155119.50925414843 145002.36121499792 140569.13781372472 135542.4893683007 127343.59361425314 141261.85600069628 124714.10393505829 129618.31655809667 1.1960430679026326 1.0808724107464012 1.1967406565153296 1.1186872740320302 1.0844851371813624 1.0457047504358594 0.9824506057149418 1.0898294296036535 0.9621642006063221 1.0 16.983910076458358 -6.53032376416599 1.4761882274063658 1.0147107705753962 1.1511792167152943 0.673248850910347 0.044093034115158775 0.2405445291308628 1.0748813750867299 0.01714269874800186 0.018848956453526692 2.94900993617624e-07 6.53032376416599 0.13646844613989817 EYGS(ph)TSSIDR ddPTM_A459_Selumetinib_30min_R1 2 EYGSTSSIDR 10 0 Q9P2F8 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 EYGS(0.876)T(0.119)S(0.005)SIDR;EYGS(0.864)T(0.13)S(0.006)SIDR 195.83 0.00016886 17989200.0 4493.0 5816.200000000001 5499.2 6683.5 6141.2 5539.1 6230.2 5525.5 3108.3 4081.8999999999996 True False 4597.678158143879 5135.236600121978 4752.438844943365 5516.352189833137 5585.729544316919 5483.3816831004015 5760.250998037202 5378.945790646502 5274.558078750175 4605.851626073018 0.9982254165803192 1.114937478891459 1.0318263007085464 1.1976834335274535 1.212746305742235 1.1905250382057078 1.2506375510295005 1.1678504275294317 1.1451862775803963 1.0 12.169252221243024 -5.762915253157087 24.999834202232204 1.179818609877917 1.0549904915456583 0.3694242098869681 0.06896608529677668 36.39991907525648 616598.4047793513 0.01809420421470815 0.028566300937054694 1.7261746993640888e-06 5.762915253157087 -0.12482811833225882 EYGST(ph)SSIDK ddPTM_A459_Selumetinib_30min_R2 1 EYGSTSSIDK 10 0 O43166-3;O43166-2;O43166 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 EYGS(0.31)T(0.504)S(0.152)S(0.035)IDK 128.88 0.007116 7661900.0 45380.0 29327.0 39486.0 39286.0 39367.0 27050.0 26825.0 32404.0 19773.0 30796.0 True False 42857.96127053335 31576.286598832256 36945.51374910619 33935.179027869926 34421.365514554695 30775.891964548275 28072.415652729112 32498.290275229036 23728.152503780664 29906.839462382726 1.4330488289958134 1.0558215835059865 1.2353533309856033 1.1346962647308187 1.1509529637142168 1.0290586540666946 0.9386620638412501 1.0866507748538883 0.7934022093383118 1.0 14.868187834878954 -4.78255327051848 0.31421916232566827 0.919478095137538 1.6200368313776443 0.58639420093049 0.10532491062632762 5.4372071175766745 0.4372735054904313 0.11031602548396452 1.472022479583569 1.6498586174123773e-05 4.78255327051848 0.7005587362401063 EYIEHCNTPT(ph)TDSDSSIAVK ddPTM_A459_Selumetinib_30min_R2 1 EYIEHCNTPTTDSDSSIAVK 20 0 Q9NVR5-2;Q9NVR5 Q9NVR5-2 DNAAF2 Protein kintoun 1 EYIEHCNT(0.164)PT(0.529)T(0.246)DS(0.052)DS(0.004)S(0.005)IAVK 93.404 0.0017070999999999998 5830800.0 27635.0 26766.0 24496.0 30005.0 31085.0 27769.0 29058.0 27536.0 28665.0 30898.0 True False 26099.157331670085 28818.86613374515 22919.954029228214 25918.267238487937 27179.82439657411 31593.92768811613 30409.25457733466 27616.125201169816 34398.800967019335 30005.89445735489 0.8698010108901384 0.9604401620056094 0.7638483852498585 0.8637725256057143 0.9058161700596108 1.0529240424083406 1.0134426960860319 0.9203566732669318 1.14640145175168 1.0 14.87295831590635 -6.631849364766269 4.391359750977765 1.0204634600874203 0.8661903213682735 0.5610679231666144 0.06857965027261634 0.1724469587690878 5.8346852594980065 0.023000057798314197 0.022927330232005556 2.3342675636250237e-07 6.631849364766269 -0.15427313871914683 EYIPGQPPLS(ph)QSSDS(ph)SPTR ddPTM_A459_Selumetinib_30min_R1 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 2 EY(0.003)IPGQPPLS(0.458)QS(0.536)S(0.187)DS(0.512)S(0.262)PT(0.042)R 110.33 0.012015 4662700.0 1235.9 1663.1 1488.6 1570.1 1705.2 1585.9 1681.1 1569.0 640.6 1481.1 True False 1264.6940653572271 1468.3834788457857 1286.456296294496 1295.9115094272465 1550.9649610775123 1569.9472858819893 1554.2932735386246 1527.3850231697331 1087.0514124271672 1671.2136121357091 0.7567518934584462 0.8786330294242165 0.7697737063369675 0.775431399084376 0.9280471088884165 0.9394055161360805 0.9300386630721207 0.9139376391374817 0.6504562938773468 1.0 10.70668043306576 -6.257413125545021 24.688010983846915 0.8934518746967978 0.7992983418230619 0.21451258246837068 0.09220179722109176 503.51410246507066 3087424.0152029144 0.02759907008454042 0.034291934356191406 5.528239814859456e-07 6.257413125545021 -0.09415353287373585 EYIPGQPPLS(ph)QSSDS(ph)SPTR ddPTM_A459_Selumetinib_30min_R2 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 2 EYIPGQPPLS(0.711)QS(0.234)S(0.055)DS(0.724)S(0.255)PT(0.02)R 163.96 8.7984e-06 15222000.0 100950.0 85677.0 102330.0 123180.0 128460.0 95409.0 101090.0 107940.0 95720.0 108360.0 True False 95339.60313486856 92248.15040502438 95746.19920847984 106402.6715026477 112321.70635302903 108550.72371333037 105790.88530603492 108254.08752957103 114866.67464026099 105231.36524690848 0.9059998690615627 0.876622195184667 0.9098636987539483 1.011130771258084 1.0673785908743483 1.0315434324987949 1.0053170464700674 1.0287245373617477 1.09156309405228 1.0 16.68320525265851 -5.778351363735695 3.4064472857610157 1.0372085012835037 0.8913747126327577 0.8527460722561173 0.02618486921921038 0.08000405723870099 1.9376714267620032 0.007520796500547925 0.01270456961891923 1.6658988802009124e-06 5.778351363735695 -0.14583378865074603 EYIPGQPPLSQS(ph)SDS(ph)SPTR ddPTM_A459_Selumetinib_30min_R1 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 2 EYIPGQPPLS(0.009)QS(0.991)S(0.295)DS(0.42)S(0.279)PT(0.006)R 186.74 4.4496e-14 10042000.0 3978.5 5221.0 4775.2 4619.0 4750.1 4404.9 5122.0 4437.0 2631.6 4176.4 True False 4071.1913091866095 4609.722892822951 4126.754068296038 3812.378359368483 4320.45429369827 4360.5907053291985 4735.643416254141 4319.316346592801 4465.632995540638 4712.481621580968 0.8639166443732008 0.9781943491752986 0.8757071962673402 0.8089959103308898 0.9168108526752877 0.925327896316821 1.0049149888600313 0.9165693775467149 0.9476181244060713 1.0 12.202271276623081 -6.820857109720512 2.775273773672229 0.9602037821677493 0.8869850934747314 0.38606687722331834 0.04641732459933382 0.32654996934970887 5.1253515142465496 0.01827169149026715 0.01637618718246851 1.5105770779914498e-07 6.820857109720512 -0.07321868869301784 EYIPGQPPLSQS(ph)SDS(ph)SPTR ddPTM_A459_Selumetinib_30min_R2 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 2 EYIPGQPPLS(0.003)QS(0.994)S(0.048)DS(0.482)S(0.463)PT(0.009)R 191.89 5.4707000000000005e-14 16447000.0 70221.0 55970.0 69109.0 77298.0 79866.0 63275.0 63590.0 71847.0 54305.0 67219.0 True False 66318.39793693527 60262.71902808469 64662.60218018993 66769.87905351253 69832.51906890098 71990.55689673916 66547.06100119447 72056.06287508883 65167.51740847669 65278.212814063736 1.0159346446238404 0.9231674157461233 0.9905694318619401 1.0228509049979295 1.0697676308603847 1.1028267134364513 1.0194375448167503 1.1038302025873608 0.9983042518963816 1.0 15.994313939316237 -5.8301381013131435 2.594936875678109 1.054913163714279 0.9680245408435988 0.3773607166807329 0.041217354834420336 0.24071710007233402 3.2952401054987437 0.011590392931964563 0.019859965979507645 1.4786381212289854e-06 5.8301381013131435 -0.08688862287068022 EYIPGQPPLSQS(ph)SDSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 2 EYIPGQPPLS(0.071)QS(0.928)S(0.059)DS(0.279)S(0.615)PT(0.048)R 164.74 3.6541e-06 15268000.0 5661.5 6236.0 4742.8 5811.2 6125.7 5187.0 6253.7 5593.5 2879.4 4976.2 True False 5793.4019346386785 5505.886220962254 4098.753810335575 4796.383009734168 5571.631516580173 5134.823489419181 5781.978374117245 5445.142209751367 4886.131496944716 5614.943742292697 1.0317827213479993 0.9805772726609879 0.7299723734474977 0.8542174650134083 0.9922862582956462 0.9144924197090044 1.0297482289210513 0.9697589966463321 0.8702013272442171 1.0 12.45505585259127 -6.265759289425046 24.9017991171919 0.9621730664539894 0.8928713677294217 0.11611333734659024 0.08527178573883881 799.8034616342763 4610404.926163114 0.027879509555738365 0.03269312459390293 5.423013812291873e-07 6.265759289425046 -0.0693016987245677 EYIPGQPPLSQS(ph)SDSSPTR ddPTM_A459_Selumetinib_30min_R1 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 EYIPGQPPLS(0.02)QS(0.422)S(0.422)DS(0.063)S(0.063)PT(0.01)R 144.17 6.5017e-05 17848000.0 1504.5 1686.6 1463.6 1329.4 1652.1 1212.0 1700.0 1381.1 715.88 1354.8 True False 1539.5519227526086 1489.1320879209322 1264.8511589793256 1097.245245928655 1502.6678467019447 1199.8083804079529 1571.7676313221482 1344.468741554951 1214.7960741935067 1528.7017768695289 1.0070976210319442 0.9741154948942184 0.8274021644492913 0.7177627857380992 0.9829699091336856 0.7848544422215018 1.028171521158829 0.8794839921676223 0.7946586394902756 1.0 10.578091274097664 -9.991742517368918 15.356395196354807 0.9999999999935015 0.8877738233479147 0.09850970773128498 0.10116664920976035 0.0 0.0 0.09821928510842601 0.0238216757043939 1.0191954651573775e-10 9.991742517368918 -0.11222617664558687 EYIPGQPPLSQSS(ph)DSSPTR ddPTM_A459_Selumetinib_30min_R1 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 EYIPGQPPLS(0.002)QS(0.161)S(0.542)DS(0.211)S(0.084)PTR 224.99 5.3976999999999997e-20 853780000.0 9356.9 10365.0 9082.5 9963.1 9448.3 7960.2 9638.4 8731.4 4629.0 7305.3 True False 9574.897564641995 9151.460981442226 7849.146386601346 8223.231615549714 8593.702933232846 7880.127615283314 8911.367728079644 8499.814908415681 7855.074911216599 8243.006414647887 1.161578322640551 1.1102091301518349 0.9522188861400559 0.9976010210227383 1.0425447344019736 0.9559773726828922 1.0810822265337647 1.0311547123524547 0.9529381048713087 1.0 13.008954902221465 -5.085503574944147 4.705080491689307 1.005653655997104 1.151404698139561 0.6483008508878851 0.040182867161130786 0.12258806070365809 4.618740914592308 0.010311586548308192 0.03095699491602115 8.21289792266916e-06 5.085503574944147 0.14575104214245682 EYIPGQPPLSQSS(ph)DSSPTR ddPTM_A459_Selumetinib_30min_R2 5 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 EYIPGQPPLSQS(0.031)S(0.613)DS(0.248)S(0.103)PT(0.004)R;EYIPGQPPLSQS(0.002)S(0.776)DS(0.108)S(0.108)PT(0.005)R;EYIPGQPPLSQS(0.038)S(0.936)DS(0.017)S(0.008)PTR;EYIPGQPPLSQS(0.114)S(0.366)DS(0.173)S(0.083)PT(0.263)R;EYIPGQPPLSQS(0.014)S(0.591)DS(0.085)S(0.265)PT(0.044)R 205.15 4.704500000000001e-16 940019700.0 683415.0 603409.0 723933.0 765232.0 826126.0 630297.0 641104.0 697683.0 578170.0 643206.0 True False 645433.5302270066 649688.5300342614 677355.9389386546 661006.0815011705 722340.6662198548 717114.6904835082 670916.6063234765 699713.1420223622 693820.1554195567 624634.9715301127 1.0332971409620977 1.0401091191592704 1.084402842958658 1.058227783631715 1.156420468182243 1.1480540206176035 1.0740938898761814 1.1201952723017368 1.1107609836829455 1.0 19.252653818436144 -5.517542630361768 1.484372555801351 1.1062695350103544 1.0328535605792568 0.2137588550542443 0.04313853424220062 0.6060283247765487 2.4950341430944807 0.01314132000516869 0.04312256498003071 3.0370879566521697e-06 5.517542630361768 -0.0734159744310976 EYIPGQPPLSQSSDS(ph)SPTR ddPTM_A459_Selumetinib_30min_R1 2 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 EYIPGQPPLSQS(0.005)S(0.042)DS(0.465)S(0.465)PT(0.023)R;EYIPGQPPLSQS(0.005)S(0.017)DS(0.462)S(0.462)PT(0.055)R 220.89 2.6561e-19 905599000.0 13796.599999999999 16821.800000000003 14935.5 15550.6 16233.4 12487.3 15045.2 14473.099999999999 7148.1 11838.2 True False 14118.033936489608 14852.295835757353 12907.341134829006 12834.979630914822 14765.09183623954 12361.689099561236 13910.328451039983 14089.2263727456 12129.803623432148 13357.74828383292 1.0569172016496877 1.1118861892114935 0.9662812070243121 0.9608640137686371 1.1053578434405706 0.9254321040412755 1.041367763148813 1.054760583398476 0.9080724809070574 1.0 13.705389212695577 -5.259263786923732 24.889885646486672 0.99907822451871 1.0844016980988609 0.27068214533957147 0.05825607428724797 230.30471018736463 2634750.574110402 0.014461423879873182 0.03457438966727436 5.5047324188888125e-06 5.259263786923732 0.08532347358015091 EYIPGQPPLSQSSDS(ph)SPTR ddPTM_A459_Selumetinib_30min_R2 3 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 EYIPGQPPLS(0.004)QS(0.062)S(0.034)DS(0.56)S(0.305)PT(0.034)R;EYIPGQPPLSQS(0.009)S(0.033)DS(0.42)S(0.42)PT(0.118)R;EYIPGQPPLSQSS(0.001)DS(0.678)S(0.318)PT(0.003)R 182.98 2.4414e-13 750120000.0 274657.0 254667.0 312895.0 328588.0 327169.0 247670.0 276395.0 272156.0 257704.0 296265.0 True False 259392.66347908488 274199.14001653146 292763.6763543174 283833.7475540833 286067.10529203 281784.2943755886 289247.9151663021 272947.92890214844 309252.0008513778 287711.05966108677 0.901573487597731 0.9530364955018696 1.0175614267285464 0.9865235903285372 0.9942860925437025 0.9794002868972792 1.005341662941375 0.948687649420468 1.0748700491933312 1.0 18.134261154017764 -4.944875281830994 2.9560011326646345 0.9975465476138591 0.8994791344722809 0.509830429769632 0.030664245605756663 0.23125297318612958 3.6284488171209768 0.007401750913417106 0.04526814276857509 1.1353368082977363e-05 4.944875281830994 -0.09806741314157819 EYIPGQPPLSQSSDSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 EYIPGQPPLSQS(0.003)S(0.02)DS(0.191)S(0.596)PT(0.191)R;EYIPGQPPLSQS(0.007)S(0.065)DS(0.201)S(0.624)PT(0.103)R 139.78 0.00012765 23267400.0 3246.1000000000004 3440.5 3698.8999999999996 4349.1 3586.2 3117.5 4019.8 3734.2 2006.1399999999999 3518.1 True False 3321.727814188925 3037.6846605549426 3196.6096966033265 3589.6113277180066 3261.828843195034 3086.140780463524 3716.583249640454 3635.1568856089343 3404.2730573316194 3969.682404195961 0.8367741990336186 0.7652210809973374 0.805255778957154 0.9042565530995077 0.821685089907262 0.7774276292736839 0.9362419637681894 0.915729903673545 0.8575681152057144 1.0 11.95480787333511 -9.325845494230979 0.15314448035880493 1.1161676763505195 0.742700525040159 0.5566803764306258 0.0476648065951813 10.066407501951259 0.6009005764419673 0.9557222356005902 0.39445378582147655 4.722310135538938e-10 9.325845494230979 -0.37346715131036046 EYIPGQPPLSQSSDSSPTR ddPTM_A459_Selumetinib_30min_R1 1 EYIPGQPPLSQSSDSSPTR 19 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 113.37 0.017437 0.0 708.31 799.46 497.26 621.84 658.4 369.08 681.95 729.76 370.09 717.32 False True 724.8122448686601 705.8588515411295 429.7348232536621 513.247317382485 598.8478362499616 365.36739029782734 630.5099624589051 710.4043942054457 628.0156996958634 809.3950092884926 0.8954987818689593 0.8720820408339587 0.5309333740906373 0.6341122832393797 0.7398709275170664 0.45140800981588397 0.77898918973217 0.8776980164850958 0.7759075513054218 1.0 9.660700143184162 -7.519693908177916 20.972353906895016 0.8617509215719898 0.6824630226951615 0.2875171371798326 0.13786113426168473 24.17898843410586 159255.82026084798 0.06603671830834151 0.039372439244810584 3.0220809400751204e-08 7.519693908177916 -0.1792878988768284 EYPS(ph)PPPSPLR ddPTM_A459_Selumetinib_30min_R2 1 EYPSPPPSPLR 11 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 EYPS(0.741)PPPS(0.259)PLR 96.82 0.019852 13323000.0 48860.0 44373.0 50340.0 50205.0 44109.0 31422.0 30153.0 32008.0 23938.0 29793.0 True False 46144.556802077095 47776.266418317005 47101.17920604784 43366.99239154432 38567.633080536805 35750.09527948378 31555.174247035993 32101.137980790343 28726.268883604003 28932.798678489682 1.5948874256807943 1.6512839614729926 1.6279510229705356 1.4988868817514656 1.3330073426049247 1.235625204348533 1.0906367751591186 1.109506838156524 0.9928617415418155 1.0 14.820418261900638 -6.5956496370691635 0.8293055221814002 1.0173477959870383 1.659048189838656 0.9825725470124277 0.03301229821748979 0.07210897891708057 0.10965200575421909 0.020270638381764645 0.023016450633799534 2.53717464653069e-07 6.5956496370691635 0.6417003938516177 EYPSPPPS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 2 EYPSPPPSPLR 11 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 EYPS(0.221)PPPS(0.779)PLR;EYPS(0.222)PPPS(0.778)PLR 103.21 0.013513 21824000.0 6816.9 7167.3 7059.799999999999 7207.7 7008.900000000001 5140.0 4964.6 5160.0 2154.7 5422.2 True False 6975.720506621634 6328.149184012625 6101.1179367055565 5949.010500285819 6374.946232521804 5088.296266746596 4590.11622497761 5023.140037957818 3656.3685269385223 6118.1921867005885 1.1401604091131847 1.0343168359059445 0.997209265502946 0.9723477652790103 1.0419656718825103 0.8316666282251272 0.7502406078310793 0.8210170397845399 0.5976223719952027 1.0 12.578889710689458 -6.835612837573624 3.863628864427004 0.7786935333569622 1.0323614367167777 0.5804653739577125 0.10072831941393823 0.1560116056647628 4.5588786818111915 0.03513703565391922 0.031380736244235326 1.4601153357403396e-07 6.835612837573624 0.2536679033598155 EYQDLLNVK ddPTM_A459_Selumetinib_30min_R2 2 EYQDLLNVK 9 0 P08670;B0YJC4;P17661;E7ESP9;E7EMV2;P07197;P12036-2;P07196;P07197-2;Q16352;P12036;B0YJC5 P08670;B0YJC5 VIM;DES;NEFM;NEFH;NEFL;INA Vimentin;Desmin;Neurofilament medium polypeptide;Neurofilament heavy polypeptide;Neurofilament light polypeptide;Alpha-internexin 0 ; 152.28 0.015571000000000003 28382000.0 144550.0 137575.0 131372.0 167131.0 140292.0 104680.0 125082.0 95645.0 96937.0 113452.0 False True 136516.48967949738 148126.56012665265 122919.66854701845 144367.46948294388 122667.26473360707 119098.71980957157 130898.56084528103 95923.31111511787 116327.10864608228 110176.34597630332 1.239072583772739 1.344449743854381 1.1156629624788605 1.3103308900260169 1.113372055014334 1.080982662423632 1.1880822483751152 0.8706343477369364 1.055826526240958 1.0 16.74945499593509 -6.847443850550155 0.6630456171295479 0.9765628791615294 1.2754602906218806 0.5666381321185665 0.08985316464885172 0.5291874728814581 0.5040293756747498 0.0680649462560758 0.06592009587243261 1.4208759044483906e-07 6.847443850550155 0.2988974114603512 EYS(ph)PPYAPSHQQYPPSHATPLPK ddPTM_A459_Selumetinib_30min_R1 5 EYSPPYAPSHQQYPPSHATPLPK 23 0 Q9UPT8 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 EY(0.001)S(0.996)PPY(0.001)APS(0.001)HQQYPPSHATPLPK;EY(0.001)S(0.963)PPY(0.004)APS(0.006)HQQY(0.023)PPS(0.003)HATPLPK;EYS(1)PPYAPSHQQYPPSHATPLPK;EY(0.029)S(0.485)PPY(0.177)APS(0.246)HQQY(0.057)PPS(0.002)HAT(0.003)PLPK;EY(0.009)S(0.981)PPY(0.007)APS(0.003)HQQYPPSHATPLPK 127.16 4.8586e-06 194485200.0 17942.499999999996 19055.6 19583.7 20490.899999999998 25770.0 18456.1 22886.8 18303.6 5079.629999999999 12132.300000000001 True False 18360.52533997253 16824.56149329191 16924.34110556397 16912.548976831276 23439.108050063038 18270.448390798014 21160.4302497316 17818.129069528062 8619.761108503608 13689.598883609528 1.3412025798619618 1.2290032481109328 1.2362919651230526 1.2354305718249032 1.712183698685762 1.3346226245294235 1.5457304797342786 1.3015815306949277 0.6296576825800203 1.0 13.740792554625518 -8.173531973776894 5.980279159065484 0.8196418401587847 1.3735912490459017 0.6392079940919855 0.16634517735801074 0.13402544174861838 7.158147730620265 0.11844129583603238 0.04330433000907998 6.706069132332621e-09 8.173531973776894 0.553949408887117 EYS(ph)PPYAPSHQQYPPSHATPLPK ddPTM_A459_Selumetinib_30min_R2 5 EYSPPYAPSHQQYPPSHATPLPK 23 0 Q9UPT8 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 EY(0.007)S(0.984)PPY(0.008)APS(0.001)HQQYPPSHATPLPK;EY(0.006)S(0.989)PPY(0.005)APSHQQYPPSHATPLPK;EYS(0.999)PPYAPS(0.001)HQQYPPSHATPLPK;EY(0.038)S(0.867)PPY(0.076)APS(0.018)HQQYPPSHATPLPK;EY(0.001)S(0.852)PPY(0.143)APS(0.004)HQQYPPSHATPLPK 126.29 6.42e-06 215280000.0 431446.0 387551.0 535337.0 673820.0 733847.0 484783.0 450752.0 516843.0 480412.0 595879.0 True False 407467.9585351809 417274.9155271257 500894.00025085564 582044.5535956655 641654.5791845815 551557.4578280817 471712.8611481435 518346.92756203504 576507.8238328171 578674.4249904269 0.7041402573509651 0.7210875364571863 0.8655886256924903 1.005823876880846 1.1088352128145227 0.9531395099018005 0.815161066010386 0.895748809999008 0.9962559237732935 1.0 19.1423923588166 -5.403526234821765 2.8907252401180124 0.9617610536478522 0.7078696933433345 0.6589055482566115 0.07276724553246668 0.18333763353586127 2.902767838037485 0.02281727546058263 0.05643042042846296 3.948878442792998e-06 5.403526234821765 -0.25389136030451775 EYVSNDAAQS(ph)DDEEK ddPTM_A459_Selumetinib_30min_R2 3 EYVSNDAAQSDDEEK 15 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 EYVSNDAAQS(1)DDEEK;EYVSNDAAQS(1)DDEEK;EYVS(0.007)NDAAQS(0.993)DDEEK 209.23 3.0828e-29 8592500.0 63635.0 43428.0 49903.0 53792.0 51959.0 43269.0 70720.0 56531.0 47927.0 38993.2 True False 60098.42145108834 46758.78795697096 46692.29531027819 46465.43680362419 45431.445900646395 49228.91199312531 74008.62012902158 56695.495850789164 57513.73919226708 37867.36499949933 1.5870769315975097 1.2348043746267845 1.2330484392271692 1.2270575680203397 1.199751973797149 1.300035320487079 1.9544169532260853 1.4972125958998934 1.5188207363524635 1.0 15.208667414333553 -7.045478968827577 24.998268227240473 1.5473583208565405 1.2819953338860524 0.1204064680469712 0.240022195614631 660.7967983456006 363215.9248056574 0.08750641601231704 0.06778513830524335 9.005773731123055e-08 7.045478968827577 -0.2653629869704881 EYVSNDAAQS(ph)DDEEKLQSQPTDTDGGR ddPTM_A459_Selumetinib_30min_R1 4 EYVSNDAAQSDDEEKLQSQPTDTDGGR 27 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 EYVS(0.007)NDAAQS(0.947)DDEEKLQS(0.045)QPTDTDGGR;EY(0.001)VS(0.013)NDAAQS(0.954)DDEEKLQS(0.032)QPTDTDGGR;EYVS(0.002)NDAAQS(0.984)DDEEKLQS(0.009)QPT(0.004)DTDGGR;EY(0.001)VS(0.023)NDAAQS(0.971)DDEEKLQS(0.004)QPT(0.001)DTDGGR 107.95 9.456e-10 139942100.0 7502.349999999999 8159.219999999999 8298.869999999999 8722.7 7663.17 6929.25 7276.67 6920.290000000001 4442.34 6988.02 True False 7677.140157968117 7203.934729281528 7171.929036429875 7199.444190357974 6970.03762654255 6859.54803625561 6727.784923419374 6736.741428930067 7538.326524323602 7885.000436078983 0.9736385204039089 0.9136251529319976 0.9095660925538641 0.9130556489782619 0.8839616031788806 0.8699489736067402 0.8532383704933485 0.854374262061561 0.9560337485627619 1.0 12.944895119465947 -1.7630541697439204 0.9215531272220497 0.8941481554845349 28.577706671449224 0.1497696058336374 0.04404269887769465 942.4911860140388 3.113964328730485 0.0140310979627462 54692.32975753056 0.017256226408866718 1.7630541697439204 27.68355851596469 EYVSNDAAQS(ph)DDEEKLQSQPTDTDGGR ddPTM_A459_Selumetinib_30min_R2 4 EYVSNDAAQSDDEEKLQSQPTDTDGGR 27 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 EYVS(0.004)NDAAQS(0.996)DDEEKLQSQPTDTDGGR;EYVS(0.002)NDAAQS(0.997)DDEEKLQSQPTDTDGGR;EYVS(0.001)NDAAQS(0.999)DDEEKLQSQPTDTDGGR;EYVS(0.004)NDAAQS(0.993)DDEEKLQS(0.002)QPTDTDGGR 137.86 1.9333e-12 290852000.0 296683.0 232123.0 238315.0 248837.0 221747.0 162385.0 228103.0 212251.0 164730.0 193279.0 True False 280194.5465761489 249926.08770691627 222982.0723577527 214944.97133223206 193889.15941666768 184752.05976573675 238710.24147751977 212868.61526995557 197680.60294076698 187698.53307084934 1.4927902844631487 1.3315292539477561 1.1879798350559572 1.1451606350652628 1.032981751346355 0.9843020973211314 1.2717746781079817 1.1340984491850314 1.0531813952224645 1.0 17.518057849487427 -5.002425852606794 1.2158341476331673 1.0922486479891136 1.5875199584821567 0.7438167221634289 0.0781234529444567 0.5607923656091333 0.9321784791879077 0.02555723492503226 0.3182581905644815 9.944298391453986e-06 5.002425852606794 0.49527131049304307 EYVTCHTCR ddPTM_A459_Selumetinib_30min_R1 1 EYVTCHTCR 9 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 159.79 0.00126 5431100.0 3575.7 4609.9 3481.8 4397.1 3488.5 3363.8 3505.0 2910.8 1567.6 2519.6 False True 3659.006852898969 4070.1707649156297 3008.9906841583897 3629.2290287896 3172.965790944698 3329.963226086031 3240.61502810831 2833.596128389075 2660.102707025955 2843.0152029823303 1.2870162808347494 1.4316387617786954 1.0583800892101987 1.2765422516849467 1.1160565682576191 1.1712787264003692 1.139851459362193 0.996686941883612 0.9356624981236472 1.0 11.473206098488843 -6.051155261851635 0.3319629243790913 0.9494882844243175 1.4469360393927904 0.6195346233460298 0.09052736625240636 2.007237728247782 0.3330742976267406 0.10291214197858889 0.37754980744611844 8.888832820519956e-07 6.051155261851635 0.4974477549684728 EYVTCHTCR ddPTM_A459_Selumetinib_30min_R2 3 EYVTCHTCR 9 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 ;; 125.71 0.006994499999999999 9479800.0 91967.0 93552.0 100194.0 102185.0 106836.0 85843.0 83090.0 99487.0 77798.0 116960.0 False True 86855.84231307049 100727.1375829082 93747.62712297906 88267.22672104294 93414.30655404193 97667.09404483243 86953.84963971151 99776.49069904043 93359.77385774173 113583.0609014249 0.7646901010041444 0.886814783679109 0.8253662683411888 0.7771161123897448 0.8224316708202926 0.8598737634795259 0.7655529702195292 0.8784451652137922 0.8219515578891264 1.0 16.79338817040893 -10.248900849309305 0.550210088924217 1.035912909885137 0.8193148434510851 0.6268732926661847 0.04128534133954985 9.299005205272888 2.0072754217777353 0.638394340549087 0.017409073905670727 5.637663506287958e-11 10.248900849309305 -0.21659806643405188 FACHS(ph)ASLTVR ddPTM_A459_Selumetinib_30min_R2 1 FACHSASLTVR 11 0 Q15233-2;Q15233;C9IZL7;C9JYS8 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 1 FACHS(0.959)AS(0.037)LT(0.004)VR 88.22399999999998 0.02047 7560700.0 24141.0 25982.0 30793.0 32175.0 37876.0 18798.0 17270.0 19221.0 19196.0 30135.0 True False 22799.33986407988 27974.735854702485 28811.811904883416 27792.70949502915 33117.6782642638 21387.253868745975 18073.089219855785 19276.92992779216 23035.736381053644 29264.924249866985 0.7790671067321662 0.9559134893311619 0.984516879623031 0.9496935395332682 1.1316509136159587 0.7308152820126703 0.6175682897910775 0.6587042482394185 0.787144917388889 1.0 14.836884923910944 -6.79698222264569 23.55364786020778 0.7286851820287897 0.9607026809520546 0.3810382094033803 0.12538107846975627 87.70295425585455 58118.334357906686 0.043284850748243245 0.03817584651675486 1.595944474084951e-07 6.79698222264569 0.23201749892326484 FADLS(ph)EAANR ddPTM_A459_Selumetinib_30min_R2 1 FADLSEAANR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 FADLS(1)EAANR 112.94 0.005600899999999999 0.0 8315.7 5523.6 8493.3 7387.0 7018.8 5462.4 5410.5 6001.7 7420.4 5723.1 True False 7853.546684384625 5947.242358826672 7946.850324805846 6380.877856714228 6137.035595131871 6214.796017269819 5662.09897070236 6019.163953365077 8904.687343299154 5557.859232600419 1.4130524642147326 1.0700599115469263 1.429840158273973 1.1480819484031326 1.104208533950304 1.1181996083700794 1.0187553757192171 1.083000432623196 1.6021793591078082 1.0 12.440313579617781 -1.5228787551641414 0.7578050801960481 1.1613733717622685 38.06068751215165 0.10167377934642352 0.18523040323646112 1032.5925141100947 4.31352248893664 0.06784717816992072 65107.27158071128 0.029999999317251027 1.5228787551641414 36.899314140389386 FADLSEAANR ddPTM_A459_Selumetinib_30min_R1 1 FADLSEAANR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 243.29 2.3876e-08 20169000.0 3943.1 3508.9 3752.0 4021.1 3972.9 3138.5 3821.0 2860.9 1909.6 2820.0 False True 4034.9665580630162 3098.0763567566473 3242.4990082607474 3318.8903703954547 3613.5518964724647 3106.9295395299982 3532.7788936952497 2785.0196384871188 3240.451728334244 3181.9744691261208 1.2680700606536155 0.9736333169283679 1.0190210637206176 1.0430285983114553 1.13563195793487 0.9764156091369481 1.110247403922594 0.8752488951465348 1.0183776644896159 1.0 11.635706544777024 -4.755001545540509 24.985225200719203 1.0192002162541436 1.268070479389407 0.5448364863974766 0.06885633925550158 169.77043871278985 658817.2724930022 0.01702533848452704 0.1574240292154719 1.7579173579793157e-05 4.755001545540509 0.2488702631352635 FADLSEAANR ddPTM_A459_Selumetinib_30min_R2 1 FADLSEAANR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 140.11 0.020135 20135000.0 84361.0 59619.0 88836.0 96620.0 89663.0 72670.0 77852.0 68094.0 57608.0 83216.0 False True 79672.55334384006 64191.58559470046 83120.38847732355 83460.18932120314 78398.73234260968 82679.6328674204 81472.27226081134 68292.14226643143 69131.20970200757 80813.33785886625 0.9858837099759638 0.7943191965020144 1.0285478941915056 1.0327526560895108 0.970121200531607 1.0230938983341276 1.0081537827715503 0.8450602843023012 0.8554430683551206 1.0 16.302305802165336 -10.499291764826289 5.127542496338531 1.0000002768124105 0.9509463525257698 0.03276192160952651 0.08224677835076011 2.745380189537353e-07 5.481127928328455e-08 0.08401180186951997 0.020375739955446927 3.167438820446132e-11 10.499291764826289 -0.04905392428664079 FADQDDIGNVS(ph)FDR ddPTM_A459_Selumetinib_30min_R1 1 FADQDDIGNVSFDR 14 0 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6;Q5H9R7-3 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 FADQDDIGNVS(1)FDR 90.453 0.018228 2442600.0 723.58 996.18 548.65 569.36 600.92 837.11 867.52 1034.4 569.68 731.4 True False 740.4380061584123 879.546782488482 474.1463435187261 469.93196421087686 546.5668921010431 828.6894334350662 802.0822679556408 1006.9643517952651 966.705352219026 825.2823144393066 0.897193594487073 1.0657526122876417 0.5745262381405316 0.5694196470575608 0.6622786924403904 1.0041284284615677 0.9718883513220227 1.2201453177624344 1.1713632235967661 1.0 9.688743913944874 -7.0646319473459185 2.1842875470761567 1.1202172618515023 0.7540702823285372 0.5034395022408779 0.15748760659483219 0.28645166083746615 2.708142245556398 0.0774946860934384 0.058117006729703026 8.617237300337733e-08 7.0646319473459185 -0.36614697952296504 FADQDDIGNVS(ph)FDR ddPTM_A459_Selumetinib_30min_R2 2 FADQDDIGNVSFDR 14 0 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6;Q5H9R7-3 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 FADQDDIGNVS(1)FDR;FADQDDIGNVS(1)FDR 140.46 0.00056227 5922800.0 78643.0 73865.0 81707.0 83134.0 82538.0 69338.0 72609.0 72968.0 65271.0 76295.0 True False 74272.33689287254 79530.2079865905 76450.06057585526 71811.00578585108 72168.83854091787 78888.68011230501 75985.46237200407 73180.32479949738 78327.02382411728 74092.16511178369 1.0024317251468766 1.073395653462176 1.0318238164658056 0.9692118684547686 0.974041431128864 1.0647371418190408 1.0255532721626361 0.9876931614711136 1.0571566333085882 1.0 16.17703337212115 -6.761458025472598 24.999999999999392 1.0261666825586477 1.012619164476098 0.05270600262583258 0.03485995133238507 2.531588028053367 3383541.139842123 0.012739590882643996 0.011966638807602065 1.7319764180451166e-07 6.761458025472598 -0.013547518082549725 FADQHVPGS(ph)PFSVK ddPTM_A459_Selumetinib_30min_R2 2 FADQHVPGSPFSVK 14 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 FADQHVPGS(0.977)PFS(0.023)VK;FADQHVPGS(0.964)PFS(0.036)VK 68.525 0.041763 14791300.0 159384.0 167323.0 196282.0 202775.0 205811.0 168168.0 177568.0 178898.0 162775.0 215167.0 True False 150526.07534470444 180156.13607175704 183653.42981568334 175156.69519361458 179955.18220631528 191331.6155228892 185825.26384431685 179418.56356184176 195334.54831350324 208954.56963899542 0.7203770446598218 0.8621784935500928 0.8789155945858274 0.8382525230064486 0.8612167827543493 0.9156613126645046 0.8893094042660163 0.8586486712007201 0.9348182652859753 1.0 17.67282978381946 -1.5228787452845154 0.08509341321874578 1.0816337268184886 0.2968652762201577 0.6856197885916719 0.03841821867278862 112.02667788767548 0.692854823215867 0.8968697615882923 10.28835690494256 0.029999999999711407 1.5228787452845154 -0.7847684505983309 FADSDQDRDPHR ddPTM_A459_Selumetinib_30min_R2 1 FADSDQDRDPHR 12 1 E9PCT3;P51636-3;P51636-2;P51636 E9PCT3 CAV2 Caveolin;Caveolin-2 0 88.155 0.021931 4838500.0 31816.0 10619.0 19477.0 25726.0 16765.0 15536.0 47641.0 31527.0 27924.0 18015.0 False True 30047.794089539184 11433.443154533345 18223.871024954184 22222.07442017466 14658.830818998387 17675.942978233714 49856.40089885061 31618.738350424177 33509.58026174944 17494.86014140878 1.717521251765753 0.653531555103513 1.041670003512626 1.2702058913621712 0.8378935699121274 1.010350630720181 2.849774190583264 1.8073158684810193 1.9153957214230735 1.0 14.094643510883285 -7.203209295574154 24.99784625779111 1.9603998470807178 1.063491209091676 0.38649284665323946 0.493108814557031 237.29263065872075 101868.32694085677 0.1781674436309926 0.13800786205523013 6.263119591272318e-08 7.203209295574154 -0.8969086379890419 FAELPEFRPEEVLPS(ph)PTLQSLATS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 FAELPEFRPEEVLPSPTLQSLATSPR 26 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 2 FAELPEFRPEEVLPS(0.666)PT(0.142)LQS(0.211)LAT(0.335)S(0.644)PR 68.01100000000001 0.0023954 8636100.0 285.48 420.27 547.37 620.45 612.15 1624.6 4445.7 5585.4 3949.5 719.49 True False 292.13112855261846 371.0645930217775 473.04016048818926 512.1000547889536 556.7811405838607 1608.2579990187792 4110.357269746394 5437.257048063881 6702.013039933022 811.8435499260831 0.35983673033950503 0.4570641634777566 0.5826740392668743 0.6307866273441223 0.6858231991059788 1.9809949825495419 5.062991841372189 6.697419778181317 8.255301209873783 1.0 9.665057922736148 -7.191496146538472 2.388336387945332 5.886844159290563 0.5548693809287242 0.616043120461331 1.7415650526751683 0.17877482595609553 1.9970173746248354 0.7600084942236499 0.5284494007598369 6.434337741053467e-08 7.191496146538472 -5.331974778361839 FAELPEFRPEEVLPS(ph)PTLQSLATSPR ddPTM_A459_Selumetinib_30min_R1 1 FAELPEFRPEEVLPSPTLQSLATSPR 26 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 FAELPEFRPEEVLPS(0.906)PT(0.021)LQS(0.009)LAT(0.029)S(0.035)PR 89.396 2.8568e-05 3655500.0 240.31 144.71 164.95 249.17 315.85 405.64 820.76 823.46 530.33 183.44 True False 245.90875543813837 127.76728592614613 142.55069600549325 205.6571370001829 287.2814232678465 401.5596298916517 758.849412402333 801.6191658249506 899.9312762293156 206.98631085691338 1.1880435687755773 0.6172740863740974 0.6886962495990204 0.9935784455927169 1.3879247476729992 1.940029890040622 3.666181639069429 3.872812470091794 4.347781611758011 1.0 7.693391547296938 -6.9880633961434775 2.0806026454944693 3.470410372099785 0.893578850301399 0.5913083736006506 0.8687911163958648 0.19755078995747238 1.7210092269924737 0.3612296846912811 0.28410476763703413 1.0278662443843269e-07 6.9880633961434775 -2.576831521798386 FAELPEFRPEEVLPSPTLQSLAT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 FAELPEFRPEEVLPSPTLQSLATSPR 26 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 FAELPEFRPEEVLPS(0.003)PT(0.005)LQS(0.073)LAT(0.459)S(0.459)PR 86.89 0.00010483 68901000.0 1306.5 1479.8 1523.7 1612.7 1448.7 1456.0 1317.6 1172.4 671.59 1232.2 True False 1336.9389079935409 1306.5443280596435 1316.7899090849962 1331.0722191282864 1317.6653407887584 1441.3539619422265 1218.2123711941547 1141.3041435080906 1139.6391790071193 1390.3648726443996 0.9615741409309015 0.9397132751021435 0.9470822623564505 0.9573546090794557 0.9477119040576949 1.0366731714106445 0.8761817816046948 0.8208666415294219 0.8196691396838778 1.0 10.441247822918188 -7.428324340756717 8.426952709345304 0.8619188445850386 0.9617839958210432 0.36387773845546645 0.05391671774073495 0.2969265865647014 24.044630502819096 0.021664814381196957 0.014556219121720127 3.729715103579064e-08 7.428324340756717 0.09986515123600459 FAELPEFRPEEVLPSPTLQSLATS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 FAELPEFRPEEVLPSPTLQSLATSPR 26 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 FAELPEFRPEEVLPS(0.048)PT(0.014)LQS(0.048)LAT(0.401)S(0.488)PR 56.485 0.0053607 39878000.0 14441.0 14572.0 12870.0 15229.0 25327.0 11690.0 33774.0 12692.0 11729.0 14300.0 True False 13638.427031903298 15689.625543634995 12041.958211796504 13154.78392850968 22145.195833747206 13300.191388745641 35344.55792191137 12728.931618726285 14075.127735641707 13887.121844137973 0.9820916950952184 1.1297967800475441 0.8671313139575895 0.9472649607422126 1.5946569838079967 0.9577356300333689 2.5451319804492822 0.916599692980977 1.0135381466090538 1.0 13.761460006122247 -6.242997645316504 23.86624192472843 1.3751227320705786 0.9839843822616929 0.12323880439388668 0.4592712325468586 948.0619947773197 1226925.747165955 0.13553765624739025 0.1745747359834627 5.714817351569228e-07 6.242997645316504 -0.3911383498088856 FAGHSEAGGGS(ph)GDR ddPTM_A459_Selumetinib_30min_R1 3 FAGHSEAGGGSGDR 14 0 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 FAGHS(0.001)EAGGGS(0.999)GDR;FAGHS(0.001)EAGGGS(0.999)GDR;FAGHSEAGGGS(1)GDR 146.59 0.00049495 19739900.0 3493.2400000000002 4471.2 4285.2 4464.43 4140.95 3580.7 3839.6499999999996 3625.04 1677.84 3444.26 True False 3574.6256953382 3947.7098253955114 3703.293376918699 3684.801108230233 3766.4018036441007 3544.6814090154717 3550.02210918005 3528.892163410587 2847.1719354149195 3886.3643209334523 0.9197865666077397 1.0157848053852359 0.9528940343990235 0.9481357906623621 0.9691324571288421 0.9120816054023693 0.9134558204073319 0.90801887625476 0.7326055151543454 1.0 11.92420543503652 -7.242238103292498 1.313380278043613 0.8684610500644028 0.9636251657107482 0.2121940957418088 0.0656520168033451 0.6074556822612865 2.0490542218750423 0.039021155142115106 0.02297400885801581 5.724820798610159e-08 7.242238103292498 0.09516411564634542 FAGHSEAGGGS(ph)GDR ddPTM_A459_Selumetinib_30min_R2 3 FAGHSEAGGGSGDR 14 0 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 FAGHSEAGGGS(1)GDR;FAGHSEAGGGS(1)GDR;FAGHS(0.001)EAGGGS(0.999)GDR 131.84 0.00056699 19306600.0 48429.3 42264.1 49878.5 50875.1 45841.8 47844.5 49308.8 43846.2 32153.8 41362.4 True False 45737.79338384843 45505.62056949932 46669.37161360462 43945.823615557354 40082.74325310828 54434.645585871745 51601.75690353361 43973.785182870844 38585.458452236046 40168.16003957851 1.1386579155924006 1.1328778944482818 1.1618498723272446 1.0940462190017326 0.9978735200620076 1.3551690077971252 1.2846432809640607 1.0947423317259881 0.9605981059181451 1.0 15.293764757722194 -8.076247198379429 4.6252905490984 0.986539251053119 1.1646468106484997 0.3852940554538479 0.0929898722232684 0.2600140708894593 10.04484470288792 0.07195182387805935 0.02614787724315124 8.389823057973154e-09 8.076247198379429 0.17810755959538072 FAGHSEAGGGS(ph)GDRR ddPTM_A459_Selumetinib_30min_R2 1 FAGHSEAGGGSGDRR 15 1 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 FAGHSEAGGGS(1)GDRR 73.953 0.021388 878220.0 2870.9 2678.5 4289.8 5289.1 5087.6 3151.4 3891.1 4611.2 2426.4 4137.1 True False 2711.346871123273 2883.9323372650524 4013.798938381092 4568.7154557935855 4448.450204278926 3585.476744439094 4072.043860068376 4624.617828574745 2911.747799280506 4017.651173523303 0.6748587057510872 0.717815512772845 0.9990411723228741 1.1371608082607687 1.107226588907128 0.8924310721816073 1.0135384293448684 1.1510750009984463 0.7247388271209797 1.0 11.972136594359375 -5.249489227111339 4.670597673627218 1.0146300127352692 0.6881305940750392 0.5150150928279645 0.11902630475543596 0.138649974423327 8.497815467547719 0.03051417602613556 0.0786945943798815 5.630030827899718e-06 5.249489227111339 -0.32649941866023 FAHEHEEMK ddPTM_A459_Selumetinib_30min_R2 1 FAHEHEEMK 9 0 P48163;P48163-2 P48163 ME1 NADP-dependent malic enzyme 0 84.615 0.020453 6350900.0 26094.0 27943.0 26698.0 27323.0 35085.0 22483.0 28760.0 30242.0 22452.0 26876.0 False True 24643.799942558344 30086.138249093656 24980.279746584543 23601.560265196003 30677.308636120382 25579.82916964656 30097.396986858872 30329.999213167383 26943.027361294877 26100.020047765884 0.9442061690932613 1.1527247179899762 0.9570981057052028 0.9042736450777652 1.1753749069915487 0.9800693303236044 1.153156086921671 1.162068042770089 1.0322991059771678 1.0 14.671763294497916 -6.2650569507990035 24.995351947198568 1.090209790101658 0.9989093404331348 0.2113229819669139 0.0879528439218739 526.4880695472962 3637719.5288747265 0.026763364751899412 0.03151551383266549 5.431790975411237e-07 6.2650569507990035 -0.09130044966852324 FAIQDIS(ph)VEETSAK ddPTM_A459_Selumetinib_30min_R1 4 FAIQDISVEETSAK 14 0 O43707;G3V2E8;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;G3V2N5;Q08043;G3V2W4;A0A087WSZ2;A0A494C033;A0A494C166;G3V2X9;G3V5M4 O43707;P12814-4 ACTN4;ACTN1;ACTN2;ACTN3 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 1 FAIQDIS(1)VEETSAK;FAIQDIS(0.992)VEET(0.007)S(0.001)AK;FAIQDIS(1)VEETSAK;FAIQDIS(0.754)VEET(0.071)S(0.175)AK 218.34 1.0611e-08 61914600.0 16961.2 20802.5 18101.5 20558.899999999998 17587.8 16062.2 16091.4 14152.7 10720.27 14260.0 True False 17356.362959249942 18366.93362918012 15643.415724422159 16968.67405334937 15996.986595378285 15900.628851310728 14877.612742739542 13777.324421551486 18191.515212457998 16090.409904162589 1.0786774894255398 1.1414832647879651 0.9722198388727938 1.0545830811283168 0.9941938515338795 0.9882053313755068 0.9246260866785441 0.8562444650951554 1.1305812170609684 1.0 13.97391345882212 -5.447387806445091 0.8786075981078196 0.9706521189815223 1.1289069565910619 0.2520432126750115 0.07315330573665195 1.2955759893588157 1.4743064155899754 0.028821222558528363 0.16374347160238278 3.5695395114635614e-06 5.447387806445091 0.15825483760953962 FAIQDIS(ph)VEETSAK ddPTM_A459_Selumetinib_30min_R2 1 FAIQDISVEETSAK 14 0 O43707;G3V2E8;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;G3V2N5;Q08043;G3V2W4;A0A087WSZ2;A0A494C033;A0A494C166;G3V2X9;G3V5M4 O43707;P12814-4 ACTN4;ACTN1;ACTN2;ACTN3 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 1 FAIQDIS(0.991)VEET(0.007)S(0.002)AK 150.37 0.00015383 0.0 8888.5 11910.0 10480.0 12585.0 9819.6 8929.1 9068.9 7268.8 7945.2 10979.0 True False 8394.512753484702 12823.458703314085 9805.728209761246 10870.901289664082 8585.974059662181 10159.002474700483 9490.621819684431 7289.951004585384 9534.462007436314 10662.007743132224 0.7873294557389441 1.2027245723559081 0.9196887158591178 1.0195923274081669 0.8052867964940947 0.9528226502409225 0.8901345833103221 0.683731542896421 0.8942463968456408 1.0 13.38019151448707 -6.253610989363666 24.51515321212627 0.8602677335710172 0.9936013282395165 0.15396440893789598 0.12519794647235077 730.3645693084803 2287184.7544763805 0.03579691689642434 0.045337287680151224 5.576850605650582e-07 6.253610989363666 0.13333359466849937 FAIQDISVEETSAK ddPTM_A459_Selumetinib_30min_R2 2 FAIQDISVEETSAK 14 0 O43707;G3V2E8;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;G3V2N5;Q08043;G3V2W4;A0A087WSZ2;A0A494C033;A0A494C166;G3V2X9;G3V5M4 O43707;P12814-4 ACTN4;ACTN1;ACTN2;ACTN3 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 0 ; 227.56 1.8550999999999996e-50 0.0 21108.8 21417.6 22278.4 22219.9 25073.2 18086.1 17706.6 20371.1 16458.9 19511.9 False True 19935.65740122155 23060.261051561694 20845.03199888788 19193.51128853451 21923.280458747995 20577.296105730744 18529.991984962267 20430.376528382858 19751.13990008981 18948.540748995507 1.052094600069843 1.2169940343709136 1.1000864011120703 1.0129282007930869 1.1569904379000893 1.0859567698806347 0.9779112930342445 1.0782031608141596 1.0423567789058823 1.0 14.209799128460347 -6.8027167578821315 0.375632092062014 1.005980059441524 1.144048502016987 0.2637825706181163 0.0594886225827961 2.2157937926372884 0.6542532960084382 0.06668196037472991 0.11667553432180484 1.5750097337199324e-07 6.8027167578821315 0.13806844257546302 FALLQVDSGSGSDS(ph)EPGKGK ddPTM_A459_Selumetinib_30min_R1 1 FALLQVDSGSGSDSEPGKGK 20 1 C9J9D2;B4DXS0;Q5VSY0-2;Q5VSY0 C9J9D2 GKAP1 G kinase-anchoring protein 1 1 FALLQVDS(0.067)GS(0.004)GS(0.078)DS(0.851)EPGKGK 86.85600000000002 0.017327000000000002 0.0 1449.2 1129.3 1937.5 1756.8 1420.1 1227.3 1410.2 1171.6 847.29 1003.8 True False 1482.963540347676 997.0810310026728 1674.398141925693 1450.0078592202974 1291.6522057390184 1214.9544762992402 1303.8274786414668 1140.5253621068573 1437.7892463868463 1132.64750784 1.3092895451434325 0.880310091269386 1.4783047067474957 1.280193395724249 1.140383214370238 1.0726677698838563 1.1511326071143821 1.0069552567875957 1.2694057387092679 1.0 10.145483233363015 -6.447596659337457 5.414895046257269 1.1037894400493191 1.2280180599643447 0.14588650145780702 0.15611518752646308 0.49500638926294627 25.908394970599 0.04878225319316603 0.05485962899434132 3.5678233270471377e-07 6.447596659337457 0.12422861991502554 FALSLS(ph)PGAHQK ddPTM_A459_Selumetinib_30min_R2 1 FALSLSPGAHQK 12 0 A0A0A0MSI9;H0Y4G9;Q99836-2;Q99836-5;Q99836;Q99836-6 A0A0A0MSI9 MYD88 Myeloid differentiation primary response protein MyD88 1 FALS(0.019)LS(0.981)PGAHQK 80.37100000000002 0.026638 3069400.0 15490.0 19614.0 29302.0 31864.0 31151.0 25959.0 17841.0 19217.0 19006.0 32383.0 True False 14629.127811383018 21118.330731049748 27416.741221605378 27524.068231534064 27237.532886526595 29534.616617660216 18670.64185127082 19272.918288454384 22807.73107201009 31448.01864886154 0.4651844039755621 0.671531359951488 0.8718114017843824 0.875224240320478 0.8661128445213712 0.9391566746202438 0.5936985111762111 0.612850001891998 0.7252517663091554 1.0 14.940681503951062 -4.882775973850269 3.0331831968158736 0.7973495421395648 0.4464210339873954 0.41441252803595197 0.12619491447209355 0.3406004969997593 5.216827737391534 0.0351308273355637 0.2579054654875333 1.3098574246607079e-05 4.882775973850269 -0.35092850815216936 FAMEPEEFDSDTLR ddPTM_A459_Selumetinib_30min_R1 1 FAMEPEEFDSDTLR 14 0 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 223.08 5.6544e-08 4185300.0 699.89 847.03 910.49 771.39 815.28 670.56 823.15 862.57 535.99 690.04 False True 716.1960752511285 747.8593338264362 786.8504589635739 636.6812172836661 741.538067949375 663.814775219766 761.0591327781326 839.6918415777673 909.5358828392718 778.6133555587901 0.9198353330802214 0.9605015486662407 1.010579196138849 0.8177116571892565 0.9523829287736695 0.8525602219388644 0.9774545059427355 1.0784452072173136 1.1681483195038724 1.0 9.604763281227429 -7.674226408278636 3.4117428370017784 1.0952334622468265 0.9215070721779404 0.5638435360352647 0.06382034625641414 0.16609420742157313 3.7949443622081835 0.03387216062679662 0.01745954770638016 2.1172570698677296e-08 7.674226408278636 -0.17372639006888613 FAMEPEEFDSDTLR ddPTM_A459_Selumetinib_30min_R2 1 FAMEPEEFDSDTLR 14 0 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 167.84 0.0028677 3748500.0 12260.0 7653.1 14906.0 15853.0 16390.0 12617.0 13486.0 14118.0 8732.8 11524.0 False True 11578.638280668545 8240.068161404954 13946.964188425685 13693.794052049636 14330.941671540928 14354.877224277478 14113.125722002029 14159.081042639287 10479.604014818984 11191.272177052164 1.0346132323017467 0.7362941434219883 1.2462358137463676 1.2236137085584355 1.2805462546900337 1.2826850242917265 1.2610832351071901 1.26518958869329 0.9364086449713498 1.0 13.450086424729003 -5.273926838917997 24.800991653309694 1.2071573192917167 0.8854536859837109 0.4415039426270684 0.13411943612736618 480.9827763976663 955266.9871557404 0.03366400465325636 0.07088040769791475 5.321979055709297e-06 5.273926838917997 -0.3217036333080058 FAPVVTT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 FAPVVTTPVK 10 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 FAPVVT(0.046)T(0.954)PVK 121.61 0.0066758 0.0 3554.8 4453.0 3049.6 3198.5 3412.2 3165.6 3970.0 3381.3 2396.2 3756.9 True False 3637.6199235632916 3931.6406898564655 2635.481070253726 2639.9420182810336 3103.5671124728374 3133.756938134829 3670.5397037346647 3291.6169399896867 4066.1763884763927 4239.134710304938 0.8581043472670447 0.9274630221821015 0.62170259978932 0.6227549249292744 0.7321227855600713 0.7392444808410924 0.8658700311674284 0.7764832129510003 0.9591996165141673 1.0 12.049554097434175 -8.228222293126066 1.1230938323774327 1.005889112014448 0.7504121798350915 0.4459548281987852 0.09424203464247595 0.48074177036850885 1.2043335299359104 0.09709550833919972 0.03238556030508461 5.912589215183757e-09 8.228222293126066 -0.2554769321793565 FAQSAPGS(ph)PLSSQPVLITVQR ddPTM_A459_Selumetinib_30min_R1 2 FAQSAPGSPLSSQPVLITVQR 21 0 Q01167-2;Q01167 Q01167-2 FOXK2 Forkhead box protein K2 1 FAQSAPGS(0.535)PLS(0.15)S(0.316)QPVLITVQR;FAQSAPGS(0.94)PLS(0.047)S(0.013)QPVLITVQR 183.6 1.0154e-14 204456000.0 1705.21 2144.0 2059.4700000000003 2095.21 2314.0 1898.6399999999999 1696.1100000000001 2047.8 1084.6599999999999 1461.57 True False 1744.9380752389338 1892.9794832814407 1779.8052858589456 1729.3209054627494 2104.699108569881 1879.5414054271896 1568.1710571540057 1993.4856918081439 1840.5887995679836 1649.1767463973995 1.0580661406066532 1.1478329945026355 1.079208332125045 1.04859646441197 1.2762119725296655 1.1396846393408215 0.9508811354390307 1.208776255281844 1.1160652147131718 1.0 10.687530308959914 -10.150450457889438 9.355549863086301 1.0000000075320306 1.115504742361853 0.13877644010167833 0.08505924897764633 0.0 0.0 0.08208249429786468 0.01990792905907385 7.072118712213206e-11 10.150450457889438 0.11550473482982238 FAQSAPGS(ph)PLSSQPVLITVQR ddPTM_A459_Selumetinib_30min_R2 2 FAQSAPGSPLSSQPVLITVQR 21 0 Q01167-2;Q01167 Q01167-2 FOXK2 Forkhead box protein K2 1 FAQSAPGS(0.957)PLS(0.034)S(0.009)QPVLITVQR;FAQSAPGS(0.944)PLS(0.044)S(0.012)QPVLITVQR 251.56 4.6471e-39 156562000.0 152137.0 136447.0 163731.0 178029.0 176728.0 119297.0 122336.0 138748.0 106257.0 130186.0 True False 143681.8345926647 146912.04615374454 153196.7257168341 153781.14308284514 154525.8486716342 135729.0788796568 128024.86640418506 139151.73370903207 127511.36906863992 126427.19191615008 1.1364788888766775 1.162028863625956 1.2117387359076859 1.216361296585919 1.2222516875493041 1.0735750499756094 1.0126371112402353 1.1006471914785645 1.0085755060763264 1.0 16.947947265669633 -6.871525158066106 4.844995298813188 1.0395667451560733 1.1905816086530687 0.8152704492598422 0.03615360565150776 0.09398951366972785 3.6022702738175005 0.013362299020443105 0.011794614092666285 1.344233894844376e-07 6.871525158066106 0.15101486349699544 FARS(ph)DDEQSSADKER ddPTM_A459_Selumetinib_30min_R1 2 FARSDDEQSSADKER 15 2 P27540-3;P27540-4;P27540;A6NGV6 P27540-3 ARNT Aryl hydrocarbon receptor nuclear translocator 1 FARS(1)DDEQSSADKER;FARS(0.999)DDEQSSADKER 105.99 0.0051952 27694000.0 4135.5 4360.299999999999 6311.200000000001 6149.0 5103.5 4696.1 4572.5 4890.200000000001 2992.0 4203.7 True False 4231.849103717787 3849.794048951524 5454.173704940098 5075.192581025502 4641.889326096108 4648.861497717647 4227.592643659131 4760.49601039173 5077.205472966102 4743.285842505488 0.8921766986495693 0.8116302025175851 1.1498724483488236 1.0699740115903904 0.978623148640812 0.9800930519637491 0.891279333363144 1.0036283218970314 1.0703983781597761 1.0 12.21167109618289 -5.237205664712858 24.998745325139826 1.012685865636035 0.8519034226643203 0.48900675111697867 0.06773609689585923 720.6806556050221 743429.2331050176 0.018542058871077325 0.04900354393604056 5.791543668434923e-06 5.237205664712858 -0.16078244297171462 FAS(ph)DDEHDEHDENGATGPVK ddPTM_A459_Selumetinib_30min_R1 6 FASDDEHDEHDENGATGPVK 20 0 P05455 P05455 SSB Lupus La protein 1 FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(0.99)DDEHDEHDENGAT(0.01)GPVK;FAS(1)DDEHDEHDENGATGPVK 131.35 0.00010369 1457530000.0 28679.2 37764.299999999996 22941.100000000002 24200.100000000002 24012.6 25070.199999999997 30212.8 29003.9 15604.9 29709.3 True False 29347.36955999109 33342.83819985323 19825.824626442085 19974.006827138604 21840.664569768865 24818.01654992033 27933.824171535176 28234.6223540552 26480.375563198108 33522.77804808819 0.8754456303678798 0.994632310962509 0.5914135337471756 0.5958338774455396 0.651517142715278 0.7403329316657187 0.8332789165463643 0.8422518656882443 0.7899218711889627 1.0 15.032854090344719 -8.769452420035785 0.7367935279282443 0.9972787179190773 0.74426206264347 0.2641081258706798 0.1202933035782748 1.5853559634326315 1.744430069184658 0.13655412673776054 0.04966921224370741 1.7003862325103001e-09 8.769452420035785 -0.25301665527560735 FAS(ph)DDEHDEHDENGATGPVK ddPTM_A459_Selumetinib_30min_R2 8 FASDDEHDEHDENGATGPVK 20 0 P05455 P05455 SSB Lupus La protein 1 FAS(0.981)DDEHDEHDENGAT(0.019)GPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(0.998)DDEHDEHDENGAT(0.002)GPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK;FAS(1)DDEHDEHDENGATGPVK 154.95 1.5828e-06 2723126000.0 2739928.0 2032834.0 2588087.0 2867708.0 2794328.0 2438231.0 2887361.0 3149999.0 2486545.0 2296246.0 True False 2587653.770560817 2188745.8312084586 2421572.3001160687 2477121.223327768 2443279.535030725 2774075.188192702 3021629.0076972796 3159164.9755795943 2983923.4798722146 2229947.4116163966 1.1604102218200445 0.9815235192573117 1.0859324697530741 1.110842888233048 1.095666885372733 1.2440092415371757 1.355022540871054 1.416699317267597 1.3381138336842178 1.0 21.088578257095392 -6.84186472130709 2.9772973074281217 1.3117335311561735 1.0793553487332996 0.38543366555738356 0.11324186294207074 0.22182250109156146 3.97164174048114 0.040836545296094644 0.03625371955218789 1.4392468204425961e-07 6.84186472130709 -0.2323781824228739 FAS(ph)DDEHDEHDENGATGPVKR ddPTM_A459_Selumetinib_30min_R1 10 FASDDEHDEHDENGATGPVKR 21 1 P05455 P05455 SSB Lupus La protein 1 FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR 102.92 0.00010249 3662166000.0 45578.310000000005 51194.560000000005 55283.560000000005 57810.26000000001 50231.439999999995 46219.08 49602.649999999994 49712.72000000001 27932.159999999996 43041.87000000001 True False 46640.19594304714 45200.677115494764 47776.3562028581 47714.78332398041 45688.01512108105 45754.15801876699 45861.08217517736 48394.177175927616 47398.83543575026 48566.713277817566 0.96033255691506 0.9306925271416254 0.9837263627365854 0.9824585627410314 0.9407269308040382 0.9420888285570853 0.9442904219776392 0.9964474412566693 0.9759531217320254 1.0 15.567680235722968 -7.765494330490378 24.99977002078489 0.989650218269443 0.9551016062482502 0.4718169584116314 0.01739173104064436 103.0759230528894 635471.1594650147 0.009681412589244712 0.004919792015761939 1.7159541109463516e-08 7.765494330490378 -0.03454861202119275 FAS(ph)DDEHDEHDENGATGPVKR ddPTM_A459_Selumetinib_30min_R2 10 FASDDEHDEHDENGATGPVKR 21 1 P05455 P05455 SSB Lupus La protein 1 FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR;FAS(1)DDEHDEHDENGATGPVKR 135.69 1.8402e-05 2803354200.0 1059442.0 1005610.0 1093332.0 1061421.0 1151278.0 743153.0 806971.0 834008.0 714871.1000000001 1130964.0 True False 1000562.4549223533 1082737.0534542152 1022988.2094498761 916853.6287466459 1006644.1650840926 845515.5800787419 844496.7504827005 836434.8252025439 857865.2951674211 1098310.1307226324 0.9110017534519452 0.985820874420806 0.9314201707097081 0.8347857341017174 0.9165390875724435 0.7698331795614373 0.7689055457651697 0.7615652462863218 0.7810774672568933 1.0 20.06685405616262 -6.078232851874917 1.1587955479381742 0.8037878876596911 0.9523713292186292 0.2858510328070498 0.07508336800068922 0.5150517963613442 1.4144046158294064 0.028642990190308037 0.05160091006121204 8.351551203509004e-07 6.078232851874917 0.1485834415589381 FATHAAALS(ph)VR ddPTM_A459_Selumetinib_30min_R2 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 FAT(0.001)HAAALS(0.999)VR 86.738 0.021856 3172500.0 23497.0 21930.0 23701.0 22048.0 24760.0 15436.0 14988.0 19761.0 14230.0 25926.0 True False 22191.13080594363 23611.96048393601 22176.10346369765 19045.02436507856 21649.427442791533 17562.16888594335 15684.971698158573 19818.501238390352 17076.397619420364 25177.4490161623 0.8813891666188404 0.9378217971478625 0.8807923093980657 0.7564318510923359 0.8598737476896089 0.6975356746694062 0.6229770016847153 0.7871528694455165 0.6782417713747892 1.0 14.619844495880022 -5.816763570514744 1.3305267395310558 0.7465422944534326 0.9185548519257442 0.22688276113975536 0.1015589700450495 0.5657653487645096 2.0135873359968097 0.0339333572856329 0.07783767450800308 1.5248826724880073e-06 5.816763570514744 0.1720125574723116 FAVLHGEAPR ddPTM_A459_Selumetinib_30min_R2 1 FAVLHGEAPR 10 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 112.36 0.011644 2308200.0 30154.0 28565.0 31794.0 33765.0 35818.0 28137.0 21606.0 24975.0 25809.0 27942.0 False True 28478.161396026062 30755.843649048405 29748.40865468982 29166.148752126148 31318.222623017235 32012.616347744755 22610.721811476807 25047.67311516617 30971.521163711892 27135.241857965273 1.049489868013341 1.1334280272877075 1.0963015848689581 1.0748438840085268 1.1541530673265066 1.1797431736672648 0.8332603751913735 0.9230679883479159 1.1413762709699422 1.0 14.727880147110618 -7.2434762100431165 24.982322561642775 0.968015141026873 1.1146638806173803 0.42522720214221943 0.07973298398532591 774.6163785986461 1077300.8659930509 0.030883274822928214 0.02387218392521063 5.70852345693593e-08 7.2434762100431165 0.14664873959050728 FCDS(ph)PTSDLEMR ddPTM_A459_Selumetinib_30min_R1 1 FCDSPTSDLEMR 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 FCDS(0.942)PT(0.058)SDLEMR 267.37 1.3538e-33 25781000.0 2183.0 2411.8 2623.8 2801.5 2585.6 1734.9 2502.6 2264.7 1008.9 1953.9 True False 2233.859652621432 2129.425334784598 2267.5023715017473 2312.2706156680665 2351.7329365247556 1717.4484811631646 2313.82686714518 2204.6327992176507 1712.0296128594573 2204.702097597706 1.0132251677246993 0.9658562656174131 1.0284846982149969 1.0487905001712339 1.0666896625567952 0.7789934445268301 1.0494963785204263 0.9999685679166673 0.7765355758154011 1.0 11.106368014660964 FCDS(ph)PTSDLEMR ddPTM_A459_Selumetinib_30min_R2 2 FCDSPTSDLEMR 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 FCDS(0.962)PT(0.035)S(0.003)DLEMR;FCDS(0.777)PT(0.206)S(0.017)DLEMR 221.09 2.7978e-08 19211900.0 62564.0 58790.0 65906.0 72896.0 69408.0 48677.0 49373.0 49527.0 46434.0 56422.0 True False 59086.943343535626 63299.0039603556 61665.679713027224 62967.439047386055 60688.346524607245 55381.81490418915 51668.942330743455 49671.11537036377 55722.09747436158 54792.95025803862 1.0783676196531695 1.1552399289006905 1.1254309071262378 1.1491886958240247 1.107594065273091 1.0107470877800404 0.9429852214092662 0.9065238344795382 1.0169574226601652 1.0 15.741702665399062 -6.837881599499646 2.7189566097191573 0.9597362192432163 1.1292472902496788 0.8254517136343578 0.03442414851384607 0.099749359506829 1.499661035425646 0.0128539829344415 0.011399090191164281 1.4525075567209536e-07 6.837881599499646 0.16951107100646257 FCDSPT(ph)SDLEMR ddPTM_A459_Selumetinib_30min_R1 3 FCDSPTSDLEMR 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 FCDS(0.15)PT(0.563)S(0.287)DLEMR;FCDS(0.146)PT(0.801)S(0.053)DLEMR;FCDS(0.315)PT(0.672)S(0.013)DLEMR 241.35 4.6955e-13 29658500.0 4260.0 4557.4 4679.5 5310.7 4869.299999999999 3857.1 4559.5 4083.2799999999997 2439.9 3704.6800000000003 True False 4359.249711482958 4023.8174893222176 4044.049602653565 4383.285939185583 4428.872674744735 3818.301075966595 4215.573244125488 3974.97815003729 4140.332096754676 4180.211764639063 1.0428298748782059 0.9625869969938354 0.9674269702943494 1.0485798772838135 1.0594852424006664 0.9134228816506579 1.0084592555299594 0.9509035364337591 0.9904598929121882 1.0 12.029360314062993 -6.751563206429822 24.999974472226207 0.9718187120464907 1.0122955811773806 0.23351741031056938 0.03910451227532513 348.00600515270287 880921.3695469431 0.013302101709391344 0.013148267731034228 1.7718901486958087e-07 6.751563206429822 0.04047686913088988 FCDSPT(ph)SDLEMR ddPTM_A459_Selumetinib_30min_R2 1 FCDSPTSDLEMR 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 FCDS(0.048)PT(0.605)S(0.347)DLEMR 201.38 0.0001874 6559400.0 20620.0 17554.0 20999.0 21509.0 25476.0 12945.0 18978.0 15338.0 15671.0 16938.0 True False 19474.022948400125 18900.335354993727 19647.947201982504 18579.437094905417 22275.477121670316 14728.056246989927 19860.51460419359 15382.631040657418 18805.637884324424 16448.95592979083 1.183906323995347 1.1490294846473013 1.1944798980461706 1.129520753427034 1.3542182991278509 0.8953793973218587 1.2074027487801862 0.9351737038092379 1.1432724341041847 1.0 14.005708393739981 -6.7641667464154205 24.999912984830836 1.042891358841702 1.1948052330581833 0.3961528746545798 0.10209402549324641 78.47574523800301 719325.6132048962 0.032725354217617963 0.030151228740027708 1.7212075942159253e-07 6.7641667464154205 0.1519138742164814 FCDSPTS(ph)DLEMR ddPTM_A459_Selumetinib_30min_R2 1 FCDSPTSDLEMR 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 FCDS(0.04)PT(0.387)S(0.573)DLEMR 92.792 0.021183 12647000.0 31853.0 30400.0 33079.0 39205.0 41270.0 22915.0 33798.0 29653.0 28145.0 31019.0 True False 30082.73777766194 32731.58224859346 30950.733153692014 33865.21136760272 36085.293641518816 26071.333248341012 35369.673969466465 29739.28532068157 33774.78643700535 30123.40087295913 0.9986501160520128 1.0865832309782664 1.0274647701374102 1.1242160707691708 1.1979156601109902 0.865484390633478 1.1741593891948885 0.9872485993896404 1.1212142539763483 1.0 14.878597036198721 -9.378507945827511 15.619003755844597 0.9999999854765577 1.0650553398511882 0.040964413074011885 0.0940095640930805 0.0 0.0 0.08527308905352557 0.02068176195237571 4.1830403531428684e-10 9.378507945827511 0.0650553543746305 FCGVNETENEDNTNRDS(ph)PIFDYSPR ddPTM_A459_Selumetinib_30min_R1 2 FCGVNETENEDNTNRDSPIFDYSPR 25 1 F8W9J4;Q03001;Q03001-9 F8W9J4 DST Dystonin 1 FCGVNETENEDNT(0.002)NRDS(0.995)PIFDYS(0.002)PR;FCGVNETENEDNTNRDS(0.999)PIFDYSPR 106.58 1.6205999999999998e-07 22954000.0 975.04 962.21 1166.94 1214.96 1210.7 1166.5700000000002 831.44 1079.9299999999998 629.44 688.27 True False 997.7565349024272 849.5540058807065 1008.4759575425902 1002.7900436237994 1101.1923987664466 1154.8353649608127 768.7238114038156 1051.286748292982 1068.113707521317 776.6161588175302 1.2847486156116088 1.0939174986704256 1.2985513449502364 1.2912299496196935 1.4179365008875346 1.4870091896093898 0.9898375184135605 1.353676119607997 1.3753431413886867 1.0 9.60105791505278 -11.100655008598089 3.0362951786372308 0.9851456582520268 1.2855561105134492 0.27653907643989073 0.13970917138185807 69601519.38512418 71500894.613545 8292155.289537797 0.03486924471304946 7.931311215054036e-12 11.100655008598089 0.3004104522614224 FCGVNETENEDNTNRDS(ph)PIFDYSPR ddPTM_A459_Selumetinib_30min_R2 2 FCGVNETENEDNTNRDSPIFDYSPR 25 1 F8W9J4;Q03001;Q03001-9 F8W9J4 DST Dystonin 1 FCGVNET(0.004)ENEDNT(0.099)NRDS(0.878)PIFDY(0.015)S(0.005)PR;FCGVNET(0.002)ENEDNT(0.028)NRDS(0.95)PIFDY(0.017)S(0.003)PR 66.711 0.0010698 10674300.0 11044.4 13176.2 11874.7 13289.6 14726.4 9718.8 12389.8 11629.3 8274.6 17429.3 True False 10430.596462236197 14186.772171839371 11110.694730195795 11479.533554161288 12876.337976313622 11057.476481517628 12965.950249922938 11663.139337665738 9929.751211641313 16926.070822240126 0.6162444061459819 0.8381609837764926 0.6564249226463605 0.6782160889388266 0.7607399325893561 0.6532807641918041 0.7660342666702209 0.6890636025427045 0.5866542398365749 1.0 14.046959487858828 -10.982128506706148 3.0957621380180127 1.0063544310186217 0.6993052403786011 0.6196720264262248 0.07183583461578875 37041345.305657685 44596232.23223848 2035148.8802093947 0.016904306116997288 1.042009055766246e-11 10.982128506706148 -0.30704919064002056 FCLS(ph)SPTEALK ddPTM_A459_Selumetinib_30min_R2 1 FCLSSPTEALK 11 0 E7EWD6;Q76L83;Q76L83-2 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 FCLS(0.477)S(0.477)PT(0.045)EALK 117.25 0.0056528 6547500.0 70943.0 49960.0 60450.0 61092.0 58722.0 44155.0 49554.0 51127.0 45917.0 58938.0 True False 67000.27206733025 53791.77135328053 56560.712812983584 52771.16421042175 51344.81737865932 50236.95045081809 51858.359189388146 51275.77110546953 55101.68302817462 57236.30680068561 1.1705904138896621 0.939819047734858 0.988196408443077 0.921987583758455 0.8970672681145856 0.8777112511077727 0.9060395767668041 0.8958609311398708 0.9627050749457962 1.0 15.80464296404881 -2.0976868282256746 1.1971443558568666 0.9191424466502786 199.99999999992957 0.7523792776118929 0.04048771156721993 544.470838891841 1.3332813915397181 0.011741078944410935 297007.4673951074 0.00798570332480187 2.0976868282256746 199.0808575532793 FCNVDDDELR ddPTM_A459_Selumetinib_30min_R2 2 FCNVDDDELR 10 0 Q86VP6-2;Q86VP6;H0YH27;Q86VP6-3 Q86VP6-2 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 ; 164.66 0.005148300000000001 7435100.0 38557.0 31280.0 37585.0 41396.0 43453.0 29486.0 32443.0 38627.0 34901.0 40192.0 False True 36414.15629590027 33679.075418947476 35166.822019453866 35757.79338791689 37994.04566525124 33547.428852741985 33951.66378458492 38739.39817495593 41882.175215417454 39031.55252864292 0.9329415290149706 0.8628679423969216 0.9009844533764585 0.9161253158371394 0.9734187651738855 0.8594951181642989 0.8698517375056969 0.9925149184503335 1.0730338021958679 1.0 15.25235322846076 -7.922481882160691 4.713922698832405 1.0359187149771407 0.9027020380204844 0.6988484242414298 0.036661394358892575 0.11090049604909324 4.4811661051197875 0.02187906831727021 0.009919732301195748 1.195413394730162e-08 7.922481882160691 -0.1332166769566563 FDALKDDDS(ph)GDHDQNEENSTQK ddPTM_A459_Selumetinib_30min_R2 1 FDALKDDDSGDHDQNEENSTQK 22 1 B4E1E4;B9A023;B8ZZL3;B9A044;B8ZZ50;O60573-2;O60573 B4E1E4 EIF4E2 Eukaryotic translation initiation factor 4E type 2 1 FDALKDDDS(0.996)GDHDQNEENS(0.003)T(0.001)QK 53.625 0.012989 4795700.0 19749.0 15738.0 21895.0 16814.0 16195.0 15231.0 15191.0 17996.0 16489.0 15443.0 True False 18651.42964151086 16945.053994354075 20486.299537473526 14523.904194232175 14160.439314863042 17328.931996748055 15897.411600395444 18048.365380601816 19787.260741154085 14997.120464267316 1.2436673884130245 1.1298871696555333 1.366015535201236 0.9684461913096821 0.9442105468581264 1.155483950271427 1.0600309331563478 1.2034553848923535 1.3194040008080172 1.0 13.872397900889247 -5.762215624721197 24.99999989828041 1.0965114219100163 1.234859721208091 0.2550222183437868 0.11963952088661416 33.83088444578117 1089634.999081466 0.035041267690509977 0.05564829542351732 1.7289577284770907e-06 5.762215624721197 0.13834829929807468 FDEILEASDGIMVAR ddPTM_A459_Selumetinib_30min_R1 1 FDEILEASDGIMVAR 15 0 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 167.71 5.5562e-05 0.0 461.21 571.85 496.36 604.76 597.65 527.23 643.87 445.61 414.03 501.31 False True 471.95529564156186 504.89753615414725 428.95703831031585 499.1500187511762 543.5926630236778 521.9265448865383 595.3023675172891 433.7909752547256 702.5786704452387 565.6580216729134 0.8343473928748875 0.8925844181629933 0.7583328121851622 0.8824236546225542 0.9609916985107396 0.9226891953957609 1.0524068336496026 0.7668785001436103 1.2420555238788753 1.0 9.143786300174032 -6.832261860382028 0.5692041863823293 1.0368892789046096 0.8212842592300568 0.31856427218377625 0.11292978066414873 1.1436884412163737 0.7999528990352808 0.09223553632986284 0.10211521317713919 1.4714250306321725e-07 6.832261860382028 -0.2156050196745528 FDGSENRPFS(ph)PSPLNNISSTVTVK ddPTM_A459_Selumetinib_30min_R1 1 FDGSENRPFSPSPLNNISSTVTVK 24 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 FDGS(0.027)ENRPFS(0.904)PS(0.068)PLNNIS(0.001)STVTVK 65.244 0.0015855 76331000.0 1273.7 1392.2 2276.9 2400.6 1576.5 1630.5 1761.7 1398.4 906.48 1196.9 True False 1303.3747318112307 1229.2005767837784 1967.7094861164453 1981.3802748430355 1433.9058533536822 1614.0986503755487 1628.8135506471929 1361.3098893566307 1538.23035332029 1350.5337737932812 0.9650811827907172 0.9101590797920507 1.4569865073345674 1.4671090151843287 1.0617326876070872 1.1951560795417842 1.2060516976723208 1.0079791529634112 1.138979552506725 1.0 10.399314003498096 -7.753754097766011 24.86728145788557 1.0551095089120732 1.1876143255417246 0.10467029273035877 0.174847533381116 410.71472278153294 1328963.2747050049 0.09183257478367457 0.0517036922217036 1.7629739788041198e-08 7.753754097766011 0.1325048166296514 FDGSENRPFS(ph)PSPLNNISSTVTVK ddPTM_A459_Selumetinib_30min_R2 2 FDGSENRPFSPSPLNNISSTVTVK 24 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 FDGS(0.001)ENRPFS(0.996)PS(0.003)PLNNISSTVTVK;FDGS(0.008)ENRPFS(0.834)PS(0.157)PLNNIS(0.001)STVTVK 84.689 6.2916e-05 52147000.0 92058.0 74252.0 104824.0 104614.0 104720.0 66475.0 78530.0 88693.0 65997.0 91334.0 True False 86941.78489737243 79946.88964218936 98079.73796374183 90365.39273078396 91564.13739132183 75631.32785003127 82181.800604243 88951.08194608349 79198.244110252 88696.95010576895 0.9802116622239714 0.9013488011352662 1.105784785686364 1.0188105974672796 1.0323256581216584 0.8526936693972313 0.9265459579640924 1.0028651699975195 0.892908313260039 1.0 16.436596877052892 -6.724645900853445 24.999994549605677 0.9346529364490901 1.0078549491716897 0.2488922600072503 0.0631392470331264 258.94173590659415 175941.8904582346 0.021290661853006865 0.021290055915102128 1.8851855366544577e-07 6.724645900853445 0.07320201272259963 FDHS(ph)PTPSASSR ddPTM_A459_Selumetinib_30min_R2 1 FDHSPTPSASSR 12 0 O15516 O15516 CLOCK Circadian locomoter output cycles protein kaput 1 FDHS(0.841)PT(0.154)PS(0.001)AS(0.001)S(0.003)R 77.633 0.030085 4224600.0 15701.0 16793.0 16596.0 18140.0 21039.0 15663.0 14570.0 14399.0 12980.0 20428.0 True False 14828.40127608295 18080.9691019944 15528.231428358567 15669.30070675458 18395.892728953593 17820.43607544251 15247.53386990728 14440.898706117221 15576.362691502203 19838.190561681844 0.7474674280387509 0.9114222915530624 0.7827443425385724 0.7898553377655511 0.9272969060235715 0.8982893888449335 0.7685949896740292 0.7279342670500565 0.7851705347355867 1.0 14.275992823281548 -10.354743878643724 13.12049786474684 1.0 0.8183077641800625 0.4005571559073582 0.06765756734608654 0.0 0.0 0.06930774158265274 0.016809596549846584 4.4183093644933606e-11 10.354743878643724 -0.18169223581993754 FDIYDPFHPTDEAYS(ph)PPPAPEQK ddPTM_A459_Selumetinib_30min_R1 7 FDIYDPFHPTDEAYSPPPAPEQK 23 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 FDIYDPFHPTDEAY(0.158)S(0.842)PPPAPEQK;FDIYDPFHPTDEAY(0.03)S(0.97)PPPAPEQK;FDIYDPFHPTDEAY(0.002)S(0.998)PPPAPEQK;FDIYDPFHPTDEAY(0.003)S(0.997)PPPAPEQK;FDIYDPFHPTDEAY(0.13)S(0.87)PPPAPEQK;FDIYDPFHPTDEAY(0.45)S(0.549)PPPAPEQK;FDIYDPFHPTDEAY(0.001)S(0.999)PPPAPEQK 173.18 6.0522e-13 731928100.0 43395.7 56221.2 56147.0 61960.1 53340.8 49403.700000000004 52136.200000000004 47559.6 24240.79 39336.119999999995 True False 44406.73537666687 49638.795767473224 48522.54579339452 51139.93167012491 48516.13405808314 48906.74363297057 48203.52445890455 46298.16491264706 41134.85015274794 44385.29416825579 1.0004830700981682 1.118361310827466 1.0932122159527713 1.1521818797970256 1.093067759654091 1.1018681874130398 1.0860246701570708 1.0430969486681774 0.9267675459537101 1.0 15.437794138448885 -8.013159831128482 3.1465801853484954 0.964440559974829 1.0957636457474818 0.6187558556091803 0.03986567852801097 0.15775750316425396 3.094176915581969 0.028708741914682225 0.010448367635086976 9.701528612502438e-09 8.013159831128482 0.13132308577265273 FDIYDPFHPTDEAYS(ph)PPPAPEQK ddPTM_A459_Selumetinib_30min_R2 7 FDIYDPFHPTDEAYSPPPAPEQK 23 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 FDIYDPFHPTDEAY(0.396)S(0.604)PPPAPEQK;FDIYDPFHPTDEAY(0.096)S(0.904)PPPAPEQK;FDIYDPFHPTDEAY(0.2)S(0.8)PPPAPEQK;FDIYDPFHPTDEAY(0.076)S(0.924)PPPAPEQK;FDIYDPFHPTDEAYS(1)PPPAPEQK;FDIYDPFHPTDEAY(0.048)S(0.951)PPPAPEQK;FDIYDPFHPT(0.025)DEAY(0.441)S(0.534)PPPAPEQK 154.33 1.0036e-08 185658700.0 416838.0 401724.0 443975.0 499715.0 478184.0 351242.6 383491.6 414735.6 341221.8 443840.0 True False 393671.8126947236 432534.9390537478 415410.1318634299 431652.9549435425 418110.2509008004 399623.0798871366 401324.71927418886 415942.4119328256 409475.6945336857 431025.1859651885 0.9133383048444838 1.003502702713714 0.9637722931044226 1.001456455443429 0.9700367043854575 0.9271455425331269 0.9310934310613618 0.9650072095007899 0.9500041015393397 1.0 18.717412646780097 -6.550259838104311 24.874953646903144 0.9507240854776896 0.974061096251219 0.05219041748547126 0.029973960038364233 438.1027558315219 398000.7488691743 0.009474936994470419 0.009475087289854038 2.8166971989376497e-07 6.550259838104311 0.023337010773529343 FDLDEEMGPPGSS(ph)PTPEPPQK ddPTM_A459_Selumetinib_30min_R1 1 FDLDEEMGPPGSSPTPEPPQK 21 0 Q969S2-2;Q969S2 Q969S2-2 NEIL2 Endonuclease 8-like 2 1 FDLDEEMGPPGS(0.013)S(0.809)PT(0.178)PEPPQK 114.92 5.1289e-05 4281700.0 1903.5 2315.5 2190.6 2234.8 2062.4 1927.9 2099.9 1992.6 1036.0 1830.3 True False 1947.8478464337577 2044.4001835532545 1893.128552104476 1844.5341323915745 1875.8562841462933 1908.5070763931435 1941.5028523608105 1939.7497751230144 1758.016333553771 2065.2368336317522 0.9431595518313683 0.9899107696806587 0.9166641429570956 0.8931344349247982 0.9083008077323363 0.9241105161953765 0.9400872678348693 0.9392384173741145 0.8512420003967637 1.0 11.012091518662293 -10.988091819250414 3.1267314342494275 1.0016030921820651 0.9243820613245765 0.31204718097296424 0.03429008636906275 15818011.317640293 17164058.672052305 216554.45269338432 0.009165545085655626 1.0277989762116876e-11 10.988091819250414 -0.07722103085748866 FDLS(ph)HGSPQMVR ddPTM_A459_Selumetinib_30min_R1 1 FDLSHGSPQMVR 12 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 FDLS(0.803)HGS(0.197)PQMVR 93.237 0.013609 12327000.0 9147.5 9487.8 9938.5 10336.0 10580.0 8203.0 9462.7 8544.8 4780.0 8396.6 True False 9360.618952063462 8376.963965241444 8588.906288272781 8531.011630749646 9623.040868050712 8120.485267728084 8748.920920536522 8318.1641465779 8111.3108826129555 9474.385399810064 0.987992208154327 0.884169643912668 0.9065396778607894 0.9004290273985128 1.0156902492317472 0.8570988961342947 0.9234288612232213 0.8779634557345172 0.8561305604873922 1.0 13.209816643839762 FDLSHGS(ph)PQMVR ddPTM_A459_Selumetinib_30min_R1 1 FDLSHGSPQMVR 12 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 FDLS(0.402)HGS(0.598)PQMVR 92.8 0.014005000000000002 11204000.0 6969.2 8087.6 7851.7 8120.9 9160.5 6983.5 8227.6 7466.5 4424.2 7594.7 True False 7131.568800297423 7140.700032176768 6785.482266300888 6702.737263172878 8331.934392417636 6913.252330510673 7606.985507921235 7268.464165389932 7507.5442692167835 8569.553723642606 0.8321983886537854 0.8332639321084174 0.7918127927222592 0.7821570970120235 0.9722716796127433 0.8067225614605402 0.8876758059097366 0.8481730087457077 0.8760717898884469 1.0 13.065004359775589 -14.5228787407249 0.1428090619205878 1.5379510540192798 0.7945852253201805 0.4931941227569214 0.049482231692131486 118.54808253180317 1.02470914516987 18.060010828299095 0.2871030066039411 3.0000000314678448e-15 14.5228787407249 -0.7433658286990993 FDLSHGS(ph)PQMVR ddPTM_A459_Selumetinib_30min_R2 3 FDLSHGSPQMVR 12 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 FDLS(0.044)HGS(0.956)PQMVR;FDLSHGS(1)PQMVR;FDLS(0.357)HGS(0.643)PQMVR 125.33 0.0019129 71619100.0 280064.0 243989.0 270291.0 287102.0 302819.0 204097.0 228462.0 240833.0 177660.0 225309.0 True False 264499.1640650211 262702.1717517131 252900.771330589 247998.2123214252 264776.1699837919 232209.50914190063 239085.9356888644 241533.78415795066 213196.96423515308 218803.74374691528 1.208842040522673 1.2006292362875381 1.1558338399507135 1.1334276465044328 1.2101080422556743 1.0612684461674087 1.0926958176977495 1.1038832335397635 0.974375303567715 1.0 17.73927789738859 -7.331858101134237 0.4857717784049028 0.9863502387028429 1.2043759744307263 0.7615148131541307 0.03897373541930902 0.4744071090060886 0.24683594154271307 0.038283485379036274 0.03421077977620881 4.65738241283404e-08 7.331858101134237 0.21802573572788342 FDPFGPIGTS(ph)PPGPRPDR ddPTM_A459_Selumetinib_30min_R1 3 FDPFGPIGTSPPGPRPDR 18 1 Q5QPM7 Q5QPM7 PSMF1 1 FDPFGPIGT(0.101)S(0.899)PPGPRPDR;FDPFGPIGT(0.18)S(0.82)PPGPRPDR;FDPFGPIGT(0.262)S(0.738)PPGPRPDR 110.77 0.006428399999999999 73535000.0 5863.3 6740.6 6858.3 7234.7 6180.5 5616.2 6088.5 5644.9 3530.74 5137.4 True False 5999.903482004233 5951.407418380075 5926.980529945284 5971.2954571385935 5621.4748662559 5559.706127101602 5629.2395431205305 5495.178914780637 5991.4079049533175 5796.835332513663 1.035030863883883 1.026664908868368 1.0224510771768267 1.0300957530475994 0.9697489308909312 0.9590933342401438 0.9710883991385592 0.9479618791237563 1.033565309566122 1.0 12.501049789018674 -6.25855721072407 24.86572680233957 0.976125857738963 1.0279888450715153 0.5186207845345769 0.022594406513759036 176.92555573496972 1526413.6206606396 0.006610424352004476 0.00814057535936083 5.513695642730169e-07 6.25855721072407 0.051862987332552346 FDPFGPIGTS(ph)PPGPRPDR ddPTM_A459_Selumetinib_30min_R2 3 FDPFGPIGTSPPGPRPDR 18 1 Q5QPM7 Q5QPM7 PSMF1 1 FDPFGPIGT(0.325)S(0.675)PPGPRPDR;FDPFGPIGT(0.252)S(0.748)PPGPRPDR;FDPFGPIGT(0.079)S(0.921)PPGPRPDR 83.065 0.004989 21339400.0 53095.0 43515.1 57509.0 62452.0 70849.0 48820.0 46425.3 52980.7 50281.5 54814.8 True False 50144.19245612535 46852.56824690032 53808.93355106486 53945.9298642909 61948.31522190377 55544.511856164434 48584.168439986744 53134.865065572965 60339.20498249366 53232.15429804573 0.9419906655546768 0.8801554035287349 1.010835166463295 1.0134087296608127 1.1637386470413433 1.0434391128559604 0.9126846185477482 0.9981723596620184 1.1335104839953631 1.0 15.700010332666432 -5.393508423505948 4.054108569825455 1.0366423843660457 0.9116463768547782 0.34824060183567984 0.06812884734748767 0.26566398860268087 7.321375683329949 0.019355235645104336 0.04312182289312435 4.0410253652964865e-06 5.393508423505948 -0.12499600751126749 FDQLFDDES(ph)DPFEVLK ddPTM_A459_Selumetinib_30min_R1 1 FDQLFDDESDPFEVLK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 FDQLFDDES(1)DPFEVLK 218.79 2.1078000000000003e-39 0.0 1249.6 1496.2 1252.7 1401.0 1528.8 1399.3 1341.3 1402.5 874.72 1154.7 True False 1278.7132487016665 1321.0242084354902 1082.59022058855 1156.3416500271144 1390.5203099315625 1385.2243124627457 1240.1246611131746 1365.3011440379541 1484.335952978912 1302.9169927304722 0.9814234182500892 1.0138974438172546 0.8308973070646718 0.8875021635904943 1.067236299541618 1.0631715759265563 0.9518063453254177 1.0478803727755104 1.1392406126105141 1.0 10.347529459135501 -6.26638224282287 24.974678015646383 1.0435431981100933 0.9275682667460713 0.43805437792721813 0.06460555564982084 427.57840584461286 2160411.8181396904 0.021116556828734007 0.02469837673624268 5.415240600178402e-07 6.26638224282287 -0.11597493136402204 FDS(ph)DAASPRMAPR ddPTM_A459_Selumetinib_30min_R2 1 FDSDAASPRMAPR 13 1 A0A140TA13;A0A140T953;D9J307 A0A140TA13 HLA-B 1 FDS(1)DAASPRMAPR 79.639 0.016561000000000003 5901700.0 5599.0 4322.6 6941.4 6748.7 7435.9 6989.1 6032.8 7387.4 6451.2 6406.4 True False 5287.829994572853 4654.129520650331 6494.7978812248775 5829.5154178431485 6501.735764210562 7951.785084267082 6313.337153766415 7408.896110950093 7741.620261588524 6221.430586173811 0.8499379558013965 0.7480802777087042 1.0439396198775541 0.9370056190610508 1.0450547786645223 1.278128072655624 1.0147725778371381 1.1908669570974952 1.244347285460856 1.0 12.603030643517764 -5.723338883417594 0.8796060036262019 1.1511589198876748 0.7737395322335134 0.5817979984296822 0.10331202462107344 0.539365979132886 0.7444689116368519 0.043133728907126044 0.1505939309955184 1.8908675839148845e-06 5.723338883417594 -0.3774193876541614 FDS(ph)NEEDSASVFSPSFGLK ddPTM_A459_Selumetinib_30min_R1 1 FDSNEEDSASVFSPSFGLK 19 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 FDS(0.998)NEEDS(0.001)ASVFSPSFGLK 87.46799999999998 0.0079379 0.0 1197.3 1910.9 1249.6 1256.4 1119.1 1177.1 1531.0 1507.4 662.36 1364.0 True False 1225.1947604597524 1687.1709396466924 1079.9111835614685 1036.9933255489411 1017.8776025931522 1165.259442721288 1415.5154373848288 1467.418855274732 1123.9765431396484 1539.0826864851176 0.796055190028674 1.0962185166930645 0.701658977158477 0.6737736280544979 0.6613534227441228 0.7571129562781652 0.9197137033732179 0.9534373092234258 0.7302899012570477 1.0 10.587855026515042 -9.761414404765539 9.32345452706922 0.9999999970159589 0.8127088020597923 0.15536713724202866 0.13279191731080708 0.0 0.0 0.13779559024154442 0.03342033960648341 1.732150387168324e-10 9.761414404765539 -0.18729119495616653 FDSSLLS(ph)SDDETK ddPTM_A459_Selumetinib_30min_R1 2 FDSSLLSSDDETK 13 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 FDSSLLS(0.5)S(0.5)DDETK;FDSSLLS(0.5)S(0.5)DDETK 164.53 0.00036268 12732700.0 3980.7 5011.4 4463.200000000001 5143.799999999999 3901.8 3952.1000000000004 4620.799999999999 4306.1 2362.1000000000004 3595.7 True False 4073.4425649061504 4424.662958263344 3857.1219546027137 4245.531891084564 3548.8828789187414 3912.3454622196946 4272.249335772577 4191.888239815926 4008.311179041852 4057.2431200839696 1.0039927222359417 1.090558989763416 0.950675579560262 1.0464080572516192 0.8747030369837174 0.9642866711272465 1.0529931801780115 1.0331863572743378 0.9879396083513219 1.0 11.986284039666323 -10.694821145206923 14.803614424912652 1.0000004431280975 1.0007954348761774 0.0 0.05816481843029013 0.0 0.0 0.05767189201909862 0.01398748837787999 2.019197755415673e-11 10.694821145206923 0.000794991748079843 FDT(ph)DDELSYR ddPTM_A459_Selumetinib_30min_R2 1 FDTDDELSYR 10 0 E9PEW5;A0A0A0MQX1;Q9HD67-3;Q9HD67 E9PEW5 MYO10 Unconventional myosin-X 1 FDT(0.847)DDELS(0.151)Y(0.002)R 106.26 0.017422 0.0 14387.0 8709.9 11050.0 10918.0 12444.0 11574.0 16517.0 17360.0 10697.0 9183.9 True False 13587.42813572417 9377.921323257367 10339.055030330333 9430.949565399478 10880.673469228504 13168.213441688791 17285.07322781459 17410.514725897294 12836.69889915247 8918.736944362143 1.5234699958622815 1.0514853596153535 1.1592510346283982 1.057431071712584 1.219979189554029 1.4764661771993284 1.9380629046068136 1.9521278443920371 1.439295606455465 1.0 13.12262369737183 -6.881668301542147 3.5443858172424902 1.666549870738602 1.181867140446523 0.2693578245118824 0.2838639590456972 0.24562519932255658 5.970539621735084 0.10218511426393453 0.08946549850891372 1.313202492787441e-07 6.881668301542147 -0.48468273029207887 FDVNWS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 FDVNWSPR 8 0 A0A1W2PPA4;A0A1X7SBU6;Q8WXG9-2;Q8WXG9 A0A1W2PPA4 GPR98 G-protein coupled receptor 98 1 FDVNWS(1)PR 81.97200000000002 0.042442 14407000.0 61238.0 43754.0 58716.0 71151.0 86478.0 73333.0 83223.0 87467.0 86779.0 52437.0 True False 57834.63711513709 47109.791108715704 54938.27648514714 61460.11105767898 75613.86051687096 83433.95509930576 87093.03440324601 87721.51448905874 104137.2248078483 50923.00756231207 1.1357270492000613 0.9251180039016683 1.0788497992370496 1.2069222538058686 1.4848663528827488 1.6384333740934602 1.710288503613507 1.7226302743748605 2.044993604912681 1.0 15.636030008276105 -6.27281855001569 1.5569346114541391 1.6807038468063082 1.0251085891389167 0.5117269362311527 0.24960073303123673 0.27903963997271564 1.3473052327337345 0.08754800249306992 0.1180677100071677 5.335577715117684e-07 6.27281855001569 -0.6555952576673916 FDWGPAPPTTFKPNS(ph)PDLAK ddPTM_A459_Selumetinib_30min_R1 2 FDWGPAPPTTFKPNSPDLAK 20 1 Q5VT82;B7ZM79;Q9HC56-2;Q9HC56 Q5VT82 PCDH9 Protocadherin-9 1 FDWGPAPPT(0.002)T(0.002)FKPNS(0.995)PDLAK;FDWGPAPPTTFKPNS(1)PDLAK 107.85 0.00024095 70981000.0 9845.7 7527.6 10687.1 7481.9 10060.0 8853.7 9007.5 11733.400000000001 4372.0 9780.6 True False 10075.085653602757 6646.265092513702 9235.85052003823 6175.326617657294 9150.07477623726 8764.639816516412 8328.057023020145 11422.192116545408 7418.964681753944 11036.035281111686 0.9129261910612404 0.6022330414155951 0.8368812064098331 0.5595602460809856 0.8291088731745655 0.7941837438230379 0.7546239941144189 1.034990540134883 0.6722490906178594 1.0 13.429934353513794 -7.290991012924131 1.1956148956740935 0.8897500365029671 0.7331010508436093 0.161643325699807 0.1374999809467413 0.8338965767480194 2.309835555499972 0.0869448104772071 0.048434837584276455 5.1169242414147235e-08 7.290991012924131 -0.1566489856593578 FDWGPAPPTTFKPNS(ph)PDLAK ddPTM_A459_Selumetinib_30min_R2 2 FDWGPAPPTTFKPNSPDLAK 20 1 Q5VT82;B7ZM79;Q9HC56-2;Q9HC56 Q5VT82 PCDH9 Protocadherin-9 1 FDWGPAPPTTFKPNS(1)PDLAK;FDWGPAPPT(0.044)T(0.044)FKPNS(0.911)PDLAK 71.905 0.005070300000000001 11760300.0 159172.0 61063.0 91596.0 106552.0 70565.0 60908.0 183696.0 122560.0 80672.0 77011.0 True False 150325.85745600128 65746.33575150862 85702.81308218435 92039.43378754788 61699.99384089595 69297.52413222578 192238.22798671838 122916.6293090997 96808.65416401124 74787.49233139215 2.010040085177476 0.8791087079130679 1.145951153201195 1.2306795015897893 0.8250041807458397 0.9265924283857564 2.570459604861308 1.6435452704369564 1.2944497956294716 1.0 16.1905093894977 FEDEDS(ph)DDVPR ddPTM_A459_Selumetinib_30min_R2 2 FEDEDSDDVPR 11 0 P49756 P49756 RBM25 RNA-binding protein 25 1 FEDEDS(1)DDVPR;FEDEDS(1)DDVPR 169.09 0.00044143 10904400.0 72808.0 57296.0 73909.0 81327.0 82002.0 69284.0 87264.0 95841.0 75162.0 59244.0 True False 68761.62283351675 61690.41896432273 69153.77540603481 70250.12230309963 71700.1756528187 78827.24210246808 91321.9489103355 96119.88144266822 90196.50020174803 57533.47178560209 1.1951585868093666 1.0722526739601508 1.2019746637876412 1.2210304736151856 1.2462341212435204 1.370110992018994 1.5872838206365476 1.670677580537083 1.5677221867970075 1.0 15.812113910031385 -6.823173365125378 2.1090903456487404 1.5105853717834623 1.1713707095091512 0.32988083727549977 0.176782747264876 0.29868806893908634 2.727606749351196 0.0687640822232461 0.06070752843428154 1.5025420496726699e-07 6.823173365125378 -0.3392146622743111 FEDEDSDDVPR ddPTM_A459_Selumetinib_30min_R2 1 FEDEDSDDVPR 11 0 P49756 P49756 RBM25 RNA-binding protein 25 0 132.78 0.026959 5566800.0 25918.0 19026.0 25411.0 24579.0 32985.0 22273.0 23391.0 27203.0 21549.0 18965.0 False True 24477.58131797451 20485.233021767745 23776.083925404884 21231.29779886002 28841.129410358586 25340.903575836757 24478.727848387178 27282.156226300925 25859.402129366797 18417.431173012355 1.329044267250597 1.1122741727296586 1.2909554922211264 1.1527827957880963 1.5659691701533494 1.3759195480512822 1.329106519711426 1.4813225563333898 1.404072147002748 1.0 14.168784230750733 -6.230216566402991 24.972975892399987 1.3827759893109945 1.2184571279299137 0.15809300345377908 0.1504137899109384 998.3736062417867 798530.0099666609 0.04134759603646204 0.0533742922646912 5.885500942644398e-07 6.230216566402991 -0.16431886138108087 FEDEGAGFEESS(ph)ETGDYEEK ddPTM_A459_Selumetinib_30min_R1 2 FEDEGAGFEESSETGDYEEK 20 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 FEDEGAGFEES(0.047)S(0.953)ETGDYEEK;FEDEGAGFEES(0.178)S(0.82)ET(0.003)GDYEEK 180.03 1.7835e-13 4862700.0 6756.0 6094.4 2588.52 2017.9099999999999 3790.87 3471.1800000000003 6903.3 7744.0 4250.6 8964.9 True False 6913.401655112408 5380.864814790305 2237.0132017225774 1665.519899362038 3447.986477832457 3436.26308077927 6382.578523121283 7538.603963942901 7212.957748459124 10115.63224052084 0.6834374254353524 0.5319355910583452 0.22114418046571815 0.16464812675675947 0.3408572391570974 0.33969830051891464 0.6309618985113138 0.7452429847879434 0.713050610871925 1.0 13.304298872629905 -7.636913389208785 1.4661940423376791 0.8553128220043221 0.36526087972555993 0.625700176120041 0.15414907977375114 0.30930125739361336 1.2617285816851884 0.12653801734587644 0.05431469402327691 2.307207266226577e-08 7.636913389208785 -0.4900519422787622 FEDEGAGFEESS(ph)ETGDYEEK ddPTM_A459_Selumetinib_30min_R2 1 FEDEGAGFEESSETGDYEEK 20 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 FEDEGAGFEES(0.181)S(0.655)ET(0.161)GDY(0.003)EEK 92.565 0.00091356 2529500.0 27147.0 10384.0 21714.0 26461.0 26861.0 28318.0 55833.0 52533.0 38316.0 16537.0 True False 25638.27841805131 11180.41941017745 20316.944880415642 22856.96615222895 23486.481039613227 32218.54745479033 58429.34513099066 52685.862332693665 45980.27063848986 16059.533841713965 1.596452217775896 0.6961857996859647 1.2651017819485664 1.423264608892877 1.4624634358070892 2.006194437045489 3.638296460338275 3.280659504315396 2.8631136552082252 1.0 13.971142396065444 -6.950360547161535 3.172456863461132 2.88682153744198 1.2580790490279419 0.4643859706135226 0.6956299894020587 0.18876612412429256 3.8902788929179883 0.2578145226078208 0.21643361864750252 1.1210873517682561e-07 6.950360547161535 -1.6287424884140382 FEDEGAGFEESSET(ph)GDYEEK ddPTM_A459_Selumetinib_30min_R2 1 FEDEGAGFEESSETGDYEEK 20 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 FEDEGAGFEES(0.062)S(0.356)ET(0.576)GDY(0.006)EEK 88.01899999999998 0.0027673000000000003 2504900.0 42164.0 21525.0 31278.0 41177.0 45578.0 49861.0 82948.0 85581.0 69948.0 26947.0 True False 39820.69367586532 23175.898286216256 29265.607532911486 35568.621565712994 39852.08416751017 56728.90015690727 86805.24635834375 85830.02654130277 83939.55451041555 26168.97009328574 1.5216759977146461 0.8856251584835038 1.1183324153983523 1.3591907300485988 1.522875528744448 2.1677926167779296 3.3171059483390084 3.2798396817047246 3.2075987022489736 1.0 14.675569526306537 -6.86206342321535 2.3548125933508595 2.886361720118921 1.2150181167877516 0.5045754076241378 0.6567854319162397 0.20773129806230736 2.350891287871245 0.24958748041653206 0.21638748712181038 1.373841328214721e-07 6.86206342321535 -1.6713436033311693 FEDENFILK ddPTM_A459_Selumetinib_30min_R1 2 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 ; 143.7 0.027844 49593000.0 5405.1 5500.8 4343.5 4504.5 6455.799999999999 4731.9 4847.0 4518.4 5057.6 7626.8 False True 5531.028313506231 4856.763778747458 3753.6765571376764 3717.8736349372894 5871.874029864066 4684.301382221442 4481.38688765791 4398.557354168334 8582.377807511146 8605.774071323087 0.6427113084385061 0.564361060201614 0.43618116464920986 0.43202082742635706 0.6823179392346399 0.5443207483021058 0.5207418705763122 0.511116991651639 0.9972813295331673 1.0 13.07108925015627 -8.263684764002038 24.981261255557285 0.9986407455566312 0.5393753050454628 0.8584269945497455 0.07421800667659528 70.63442971433375 785823.2801776022 0.06410479391179832 0.01965705648031512 5.448980277665385e-09 8.263684764002038 -0.45926544051116835 FEDENFILK ddPTM_A459_Selumetinib_30min_R2 2 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 ; 168.26 0.010844 28675000.0 130439.0 85599.0 115302.0 121803.0 108596.0 109106.0 114849.0 121187.0 106115.0 96172.0 False True 123189.72256868891 92164.16805583393 107883.5948513254 105213.22127810521 94953.1996194423 124134.36113434407 120189.7060689762 121539.63410641228 127340.96510082892 93395.26447513557 1.3190146551968431 0.9868184278269334 1.1551291755273847 1.1265370023778445 1.0166810935550323 1.3291290712859656 1.286892935572489 1.3013468593878177 1.3634627603065532 1.0 16.511061780753785 -6.771802281480756 24.99288960749749 1.276920927982328 1.1156125307228302 0.21691258067901464 0.12530968942881868 264.5694945528114 638075.6661744624 0.04109899416778824 0.036635367110991204 1.691210703273076e-07 6.771802281480756 -0.16130839725949775 FEEESKEPVADEEEEDS(ph)DDDVEPITEFR ddPTM_A459_Selumetinib_30min_R1 4 FEEESKEPVADEEEEDSDDDVEPITEFR 28 1 E9PJF4;P54105 E9PJF4 CLNS1A Methylosome subunit pICln 1 FEEESKEPVADEEEEDS(1)DDDVEPITEFR;FEEESKEPVADEEEEDS(1)DDDVEPITEFR;FEEESKEPVADEEEEDS(1)DDDVEPITEFR;FEEESKEPVADEEEEDS(1)DDDVEPITEFR 158.8 1.4349e-17 275261400.0 14466.58 16867.66 17463.71 18152.25 14638.03 14685.87 15122.65 14843.729999999998 8889.41 12241.14 True False 14803.623166935471 14892.786525637606 15092.234103292461 14982.300297433756 13314.022771054097 14538.143481503083 13981.936335184635 14450.026061169698 15084.67951318168 13812.409557800896 1.071762541140026 1.0782178491968144 1.0926575873771969 1.0846985266934932 0.9639174624339658 1.0525421665687802 1.0122735122119222 1.046162583052621 1.092110645145346 1.0 13.753677397469676 FEELCSDLFR ddPTM_A459_Selumetinib_30min_R2 2 FEELCSDLFR 10 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37;P17066;P48741 A0A0G2JIW1;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 ; 128.6 0.042798 3251700.0 15550.7 9964.6 12785.5 16765.5 17006.8 15376.5 15884.2 15272.7 14201.900000000001 13610.0 False True 14686.454348384372 10728.852778761002 11962.89484979986 14482.009977899339 14870.253741278964 17494.47330103057 16622.84677394518 15317.141028468412 17042.67683424077 13217.043936973278 1.111175420042342 0.8117437476884052 0.9051112265984781 1.0957071828586007 1.1250816606337373 1.323629805912322 1.2576826447133562 1.1588931005684513 1.2894469380226308 1.0 13.69011192596049 -6.062713267195603 2.1222794218177117 1.2144294397988353 0.9308702324877706 0.4947146505151009 0.11136814733756725 0.23392930509967563 2.0919903368726738 0.03469406527348209 0.051834559804635305 8.655391822348823e-07 6.062713267195603 -0.28355920731106476 FEELNADLFR ddPTM_A459_Selumetinib_30min_R2 2 FEELNADLFR 10 0 P11142;E9PKE3;P11142-2;E9PN89;E9PNE6;A8K7Q2;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 ; 188.91 0.0024637 15749300.0 38114.0 30118.0 39520.0 46977.0 42279.0 36192.0 43442.0 37578.0 36389.0 34429.0 False True 35995.776462430775 32427.953755366365 36977.326226122575 40578.65156015493 36967.534040944374 41177.119481734975 45462.13907868993 37687.34575862722 43667.81679361124 33434.94531271511 1.076591456207401 0.9698820635735932 1.1059484584250336 1.2136598753377688 1.1056555856511554 1.2315593489568404 1.3597192594001628 1.1271843098931271 1.3060531843312042 1.0 15.02906913715123 -5.565734080538007 3.4375234072823546 1.2022828687184157 1.0235522946965296 0.3146639384687724 0.09927187227093011 0.24561977123715745 5.986224456470738 0.026602982176085758 0.05250700895608089 2.7181030598694713e-06 5.565734080538007 -0.17873057402188608 FEEPAPLSYDSRPR ddPTM_A459_Selumetinib_30min_R2 2 FEEPAPLSYDSRPR 14 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 ; 171.99 0.00036859 3522200.0 32159.0 31868.0 39831.0 40099.0 40529.0 30431.0 25934.0 29520.0 27248.0 36521.0 False True 30371.73152267697 34312.17312822949 37268.31682471377 34637.44702536673 35437.38468614289 34622.594024886115 27139.98238724609 29605.898312700905 32698.361372731295 35466.54383704636 0.8563487793516651 0.967451840976648 1.0508020458927656 0.9766231292372616 0.9991778406422277 0.976204340179358 0.7652277174777089 0.8347556629348317 0.9219494722397061 1.0 15.114171128145239 -7.199524476032343 22.937365811657102 0.8667128561368433 0.9760856594302442 0.26307133486712875 0.0725703776071972 109.79588964456838 40675.25385027917 0.02763568371958564 0.021406496309347784 6.31648579740722e-08 7.199524476032343 0.10937280329340082 FEETTADGR ddPTM_A459_Selumetinib_30min_R2 1 FEETTADGR 9 0 I6L8B7;Q01469 I6L8B7 FABP5 Fatty acid-binding protein, epidermal 0 140.14 0.032122000000000005 11354000.0 58679.0 51778.0 61938.0 62423.0 76960.0 58347.0 65007.0 65911.0 54562.0 49010.0 False True 55417.85609064846 55749.206107489226 57952.97651299548 53920.87971431874 67291.59676887064 66383.76962866912 68029.95430892681 66102.79009784652 65475.924589656686 47594.95395672738 1.1643641076117763 1.1713259804427076 1.2176285865448144 1.1329116898262532 1.4138388878377979 1.3947648670702413 1.4293522454245595 1.388861309918404 1.375690470237379 1.0 15.53852100586625 -6.25940354967992 24.9906256295908 1.3610250901293102 1.1748318282988217 0.28986667650313025 0.1198482578370302 193.87042170121512 2379835.6583832977 0.03359161042159815 0.041222988053580566 5.502961194927229e-07 6.25940354967992 -0.18619326183048845 FEETTADGRK ddPTM_A459_Selumetinib_30min_R2 2 FEETTADGRK 10 1 I6L8B7;Q01469 I6L8B7 FABP5 Fatty acid-binding protein, epidermal 0 ; 108.43 0.014455 11545700.0 72857.0 64895.0 72256.0 74701.0 83809.0 51246.0 55332.0 62463.0 45255.0 65446.0 False True 68807.89960967933 69872.2378296866 67607.12762638429 64526.59493358737 73280.16415803373 58304.6713351291 57905.047638277974 62644.756988693676 54307.264530349166 63556.403930870896 1.0826273255566878 1.099373682401624 1.063734312279834 1.0152650392834013 1.1529941850979988 0.9173689467790844 0.9110812452708967 0.985656096226451 0.8544735254281874 1.0 15.955749877774776 -6.776454998414496 24.99723237141429 0.9314047605346364 1.0789087042431276 0.6946546091105423 0.04937517544192912 132.22436656445234 220118.92202661335 0.016512492698568998 0.01461879572723524 1.67318900322731e-07 6.776454998414496 0.14750394370849118 FEEVEEEPEVIPGPPS(ph)ESPGMLTK ddPTM_A459_Selumetinib_30min_R2 1 FEEVEEEPEVIPGPPSESPGMLTK 24 0 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 FEEVEEEPEVIPGPPS(0.491)ES(0.49)PGMLT(0.019)K 91.615 0.00085505 0.0 4785.6 5641.8 5153.0 3965.5 4174.5 3728.3 3626.0 2686.2 3591.0 4353.3 True False 4519.6355102746675 6074.507918753767 4821.46159016219 3425.3920591309447 3650.061989496494 4241.839482862309 3794.6161847826934 2694.016397275651 4309.3003409233015 4227.608917768241 1.0690760659717284 1.4368660954477563 1.1404701059026634 0.8102433611430674 0.8633868601600371 1.0033661025347587 0.8975797569246011 0.6372435222077791 1.0193233160266362 1.0 12.045626208569946 -5.617742594414641 4.625305378480888 0.8800447056378874 1.2612778444019836 0.5555642534557031 0.13515187239997703 0.13506791058592887 4.997594028797868 0.03594303549777026 0.06444826569302702 2.411334198822825e-06 5.617742594414641 0.38123313876409626 FEEVEEEPEVIPGPPSES(ph)PGMLTK ddPTM_A459_Selumetinib_30min_R1 2 FEEVEEEPEVIPGPPSESPGMLTK 24 0 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 FEEVEEEPEVIPGPPS(0.059)ES(0.919)PGMLT(0.022)K;FEEVEEEPEVIPGPPS(0.136)ES(0.857)PGMLT(0.006)K 109.74 2.6760000000000004e-07 10726800.0 2975.13 4729.62 4710.799999999999 5481.0 4050.72 4714.5 4487.6 2898.9100000000003 1996.35 3174.99 True False 3044.4447404047646 4175.8738916593165 4071.099234572156 4523.846241112503 3684.3330912126994 4667.0764104235095 4149.096719012511 2822.021489813237 3387.6601423649313 3582.5308935215385 0.8498027877192014 1.165621181162945 1.1363751927259356 1.2627514948421492 1.0284162790822697 1.3027316579078791 1.1581468080332595 0.7877172796796905 0.9456052838207198 1.0 11.806763430109214 -7.7471488103183095 24.959314027656802 0.8999959631164501 1.1387474240043787 0.3763343396820533 0.1279537163251038 209.02067665977543 365068.2227668361 0.05930394165424518 0.03403267944471498 1.7899924108711183e-08 7.7471488103183095 0.23875146088792853 FEEVEEEPEVIPGPPSES(ph)PGMLTK ddPTM_A459_Selumetinib_30min_R2 1 FEEVEEEPEVIPGPPSESPGMLTK 24 0 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 FEEVEEEPEVIPGPPS(0.402)ES(0.579)PGMLT(0.02)K 79.942 0.0015623 0.0 3296.0 4360.9 2183.6 4217.6 2789.5 3224.5 3718.6 3803.3 2729.1 3414.1 True False 3112.8215149334046 4695.367007496418 2043.1095533239193 3643.1556042341867 2439.058071553593 3668.645605903362 3891.5222682661124 3814.366973329791 3274.9962574251686 3315.5260621028983 0.9388620257019102 1.4161755689889963 0.6162248509149287 1.098816759691971 0.7356473832109168 1.1065048312654477 1.1737269426854946 1.1504560368047594 0.9877757544599051 1.0 11.695022080180708 FEGGDRDLEHLSK ddPTM_A459_Selumetinib_30min_R1 1 FEGGDRDLEHLSK 13 1 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 85.522 0.022056 4868900.0 2684.8 3394.6 2067.2 2905.4 5531.5 3534.0 4914.3 3100.7 657.38 1896.2 False True 2747.3506162886006 2997.1586538932725 1786.4855943167966 2398.0264311126193 5031.1768016656415 3498.451168615265 4543.610394474374 3018.4593635069423 1115.5258468644565 2139.5957405521103 1.2840512645532107 1.4008060481181706 0.8349640824466235 1.1207848219467023 2.351461402875749 1.6350991462118494 2.123583585608523 1.4107615313947326 0.52137225071153 1.0 11.063122521384352 FEGTT(ph)SLGEVR ddPTM_A459_Selumetinib_30min_R2 1 FEGTTSLGEVR 11 0 Q4G0F5 Q4G0F5 VPS26B Vacuolar protein sorting-associated protein 26B 1 FEGT(0.023)T(0.489)S(0.489)LGEVR 147.28 0.0015652 2891400.0 25742.0 22155.0 27642.0 26354.0 28535.0 20391.0 21204.0 22296.0 16264.0 22169.0 True False 24311.36269339067 23854.21726044696 25863.54381433403 22764.53973681423 24950.178193863336 23199.675158931772 22190.028014928892 22360.877668698504 19517.254454128793 21528.9233680206 1.1292419169229404 1.1080079041890403 1.2013393968763035 1.0573933191024791 1.1589143482634492 1.0776049857371377 1.0307077430490699 1.0386435627298345 0.9065597067022881 1.0 14.393988553654927 -7.457909011526244 1.1143969966187437 0.9633026681252519 1.1319332058223797 0.6880373219799534 0.04484302264260148 0.28121358317418726 0.6557322069232945 0.032448736827506985 0.01573355004574266 3.4841030238067276e-08 7.457909011526244 0.16863053769712777 FEGTTS(ph)LGEVR ddPTM_A459_Selumetinib_30min_R1 1 FEGTTSLGEVR 11 0 Q4G0F5 Q4G0F5 VPS26B Vacuolar protein sorting-associated protein 26B 1 FEGT(0.042)T(0.143)S(0.815)LGEVR 129.74 0.002527 4575700.0 1971.3 2670.0 2261.3 2688.7 2652.4 2459.3 2648.5 2131.5 1578.6 1996.6 True False 2017.2274545179225 2357.3951587506754 1954.2278804317773 2219.1690181498234 2412.490888319253 2434.5616748657417 2448.7215126804176 2074.965695912227 2678.7689036177417 2252.8830585309283 0.8953982084775082 1.0463903795734066 0.8674342296781709 0.9850351573937933 1.0708460340113715 1.0806427194020818 1.086927927043489 0.9210268096495349 1.1890403691723472 1.0 11.137556713523441 -6.096490484997192 4.469462957216476 1.0561054933185536 0.9444188886478664 0.33529055960691 0.07730530799968947 0.2714166394914963 9.1857587494061 0.02192975644599206 0.0291533115346556 8.00773172536931e-07 6.096490484997192 -0.11168660467068725 FEGTTS(ph)LGEVR ddPTM_A459_Selumetinib_30min_R2 1 FEGTTSLGEVR 11 0 Q4G0F5 Q4G0F5 VPS26B Vacuolar protein sorting-associated protein 26B 1 FEGT(0.118)T(0.118)S(0.764)LGEVR 131.12 0.0022643 2834800.0 28401.0 21709.0 30084.0 30988.0 31790.0 21032.0 24141.0 27503.0 18989.0 22560.0 True False 26822.58611821105 23374.01049456299 28148.42819298258 26767.380942718362 27796.255993794126 23928.967090513113 25263.60433448399 27583.029176633234 22787.330596990392 21908.634182080597 1.224292938358962 1.0668857903374436 1.284809813292953 1.2217731475297446 1.2687352284392563 1.0922162874984227 1.1531346100592375 1.2590026811983475 1.0401073114648332 1.0 14.419211926855288 -8.389057837921643 5.141075940694902 1.002997568137792 1.1929836544817687 0.5096458136216677 0.06947206059772641 0.18049751097326952 6.326636608565899 0.06677230069225558 0.017397686488388506 4.082650113103242e-09 8.389057837921643 0.18998608634397662 FELLPTPPLS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 FELLPTPPLSPSR 13 0 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1;P04198 H0YBT0 MYC;MYCN Myc proto-oncogene protein;N-myc proto-oncogene protein 1 FELLPT(0.016)PPLS(0.816)PS(0.169)R 77.527 0.042934 2164000.0 8574.2 7779.6 9630.2 11728.0 9665.4 8544.3 11398.0 11830.0 10087.0 10747.0 True False 8097.680289242114 8376.27030464334 9010.603416568969 10130.626168071536 8451.146042227674 9721.199767567097 11928.029584708524 11864.423341438072 12104.681854328413 10436.706185940617 0.7758846656189836 0.8025779547120998 0.863357007089769 0.9706727378910596 0.8097522237056257 0.9314432728462372 1.1428921512399077 1.1367976763991638 1.1598182068816636 1.0 13.349378850174816 -7.12639318015233 3.4942815420938267 1.121518052453814 0.8509891290435906 0.7880786430673641 0.0647365281665914 0.11254333913640718 2.5131742854869414 0.026940607215146312 0.020442537426339363 7.474924661666825e-08 7.12639318015233 -0.2705289234102234 FELLPTPPLS(ph)PSRR ddPTM_A459_Selumetinib_30min_R2 1 FELLPTPPLSPSRR 14 1 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 FELLPTPPLS(0.802)PS(0.198)RR 75.143 0.023049 1355800.0 13142.0 12764.0 11150.0 12357.0 13191.0 10365.0 9378.8 9336.3 7908.2 12288.0 True False 12411.620251594302 13742.957757271275 10432.6211392021 10673.955282986015 11533.828650963771 11792.684665898074 9814.932783739636 9363.467087292333 9490.06097356993 11933.213511941774 1.0400903527933845 1.1516560684612287 0.8742507731686854 0.8944745078351612 0.966531658837887 0.9882237214725882 0.8224886593973754 0.7846559585917195 0.7952644913353022 1.0 13.542694980290289 -4.931408900968919 0.5695187177334801 0.8585490522132475 1.2338680830332123 0.3893262012543184 0.08773635107081457 3.3835823433810273 0.9415012339757662 0.05114756087847336 0.8221759097446993 1.1710922286941232e-05 4.931408900968919 0.37531903081996476 FEPES(ph)PGFESR ddPTM_A459_Selumetinib_30min_R1 3 FEPESPGFESR 11 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 FEPES(1)PGFESR;FEPES(1)PGFESR;FEPES(0.998)PGFES(0.002)R 166.62 0.00058404 90297000.0 8297.2 12136.3 10410.0 11936.699999999999 10736.699999999999 10412.599999999999 10291.5 7637.799999999999 5280.299999999999 7810.9 True False 8490.50861645925 10715.376353987198 8996.379178036892 9852.179424610038 9765.567380718347 10307.858697884356 9515.203869265819 7435.220732929118 8960.28344214669 8813.50509960894 0.9633520966404138 1.2157905660555692 1.020749301936192 1.1178503119090706 1.10802311570134 1.1695527013811704 1.0796163117541073 0.8436167732244261 1.0166537990139999 1.0 13.105500172611029 -7.616554483268461 8.06562804831844 0.9483472354633725 1.1040091153933083 0.4094977933674542 0.07876894149282791 0.2127308065019724 16.119809485061577 0.03447869515845457 0.0198118738932492 2.417939982621037e-08 7.616554483268461 0.15566187992993574 FEPES(ph)PGFESR ddPTM_A459_Selumetinib_30min_R2 2 FEPESPGFESR 11 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 FEPES(1)PGFESR;FEPES(1)PGFESR 193.15 2.0263e-05 79126000.0 112357.0 117957.0 138306.0 133492.0 139289.0 110318.0 109108.0 123072.0 94824.0 114400.0 True False 106112.6477407076 127003.92260846491 129407.54253618697 115310.15931345559 121790.27056054086 125513.30313290357 114181.73819340051 123430.11914433347 113791.44960392949 111096.97475310393 0.9551353488835026 1.1431807471869666 1.1648160791396478 1.0379234859429325 1.096251908129822 1.1297634648633568 1.0277664036050667 1.1110124233232999 1.0242533593449652 1.0 16.76146000612225 -8.418569377374311 4.430184395300033 1.0007311953432623 1.086420246889435 0.190415774020389 0.059192075179938415 0.3269914288983346 9.898916686715328 0.055172074823760776 0.014434905850294829 3.814438547831988e-09 8.418569377374311 0.08568905154617279 FEPLDSACSS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 FEPLDSACSSR 11 0 Q9UPZ3;Q9UPZ3-2;G3V159 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 FEPLDSACS(0.022)S(0.978)R;FEPLDS(0.001)ACS(0.228)S(0.772)R;FEPLDSACS(0.043)S(0.957)R 126.12 0.0032197 15394600.0 7161.3 8463.6 8950.0 8879.9 8573.9 8026.9 8386.6 7853.4 4372.6 6631.6 True False 7328.1443565358895 7472.677777379105 7734.639158830948 7329.192161367438 7798.3922588449905 7946.156673842069 7753.992009909604 7645.102320561616 7419.982837931672 7482.830457254183 0.9793278624175784 0.9986432032727354 1.03365153106371 0.9794678902903912 1.0421714488111766 1.0619185773664988 1.0362378319546912 1.0216858933573885 0.9916010900311681 1.0 12.869368372186274 -4.413056709366379 0.8973592768268949 1.0249113104540442 0.9207624213633719 0.22525219739429758 0.023871941203048582 5.767046518276093 2.320238787441214 0.008635521245749544 0.6883346227696506 3.863165292659685e-05 4.413056709366379 -0.10414888909067221 FEPLDSACSS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 FEPLDSACSSR 11 0 Q9UPZ3;Q9UPZ3-2;G3V159 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 FEPLDSACS(0.236)S(0.764)R;FEPLDSACS(0.237)S(0.763)R 158.42 0.00057299 11669100.0 64133.0 50914.0 58643.0 75370.0 66893.0 53475.0 57001.0 60745.0 51492.0 64427.0 True False 60568.74460474033 54818.94008568707 54869.973225670736 65104.475979497896 58489.303308992516 60840.695852281664 59651.65944533876 60921.75789312391 61791.83880668963 62566.82510855083 0.9680648570493402 0.8761662429023448 0.8769819010389871 1.0405590481304485 0.9348293317986971 0.9724114296470309 0.9534071665270791 0.9737070370348376 0.9876134628772255 1.0 15.933110277315947 -5.741255941695936 24.999999921236054 0.9759140755126061 0.9039805166581472 0.4663426626627535 0.035660923955232036 212.30835473561888 262971.39435806527 0.009383296463854938 0.016226601650794634 1.8144460446138036e-06 5.741255941695936 -0.07193355885445896 FEQIVS(ph)ILDK ddPTM_A459_Selumetinib_30min_R1 1 FEQIVSILDK 10 0 C9JXA2;P29320 C9JXA2 EPHA3 Receptor protein-tyrosine kinase;Ephrin type-A receptor 3 1 FEQIVS(1)ILDK 74.92 0.04051 45116000.0 4486.8 5700.0 5850.6 6310.1 5169.5 4949.2 5356.8 4596.5 2831.1 4000.8 True False 4591.333710206978 5032.641350141892 5056.120655045402 5208.159490247035 4701.919637749353 4899.415541514055 4952.732263215577 4474.585888463781 4804.169924637143 4514.3416510921215 1.017054991638976 1.1148118018325843 1.1200128492317836 1.1536919207227179 1.041551570783716 1.0853001212987003 1.097110641153489 0.9911934528440658 1.0642016701316581 1.0 12.140299892311079 -7.748819037820618 24.975486511911583 1.020773172164549 1.0924603939205906 0.3918754584691533 0.040683071495539055 221.80242484110536 438945.7412425108 0.019386581201065154 0.011100906070537245 1.7831216052408544e-08 7.748819037820618 0.07168722175604159 FERPDGSHFDVR ddPTM_A459_Selumetinib_30min_R1 1 FERPDGSHFDVR 12 1 B4DEM9;Q9Y2S7 B4DEM9 POLDIP2 Polymerase delta-interacting protein 2 0 86.911 0.023289 3364700.0 2419.1 3894.8 2591.0 3124.0 2597.5 3026.5 2150.1 2288.8 1558.9 1841.7 False True 2475.460323250804 3438.7950053566037 2239.1564313442427 2578.452044742832 2362.556583625871 2996.0561578421357 1987.9162259445582 2228.0935889298175 2645.339442448814 2078.100134677154 1.1912132057271543 1.6547782986842654 1.0775017016646842 1.240773724863557 1.1368829365832793 1.4417284845167444 0.9566027126278943 1.0721781649256117 1.2729605269284987 1.0 11.021049457826999 -1.5228801052414647 0.13820103068390396 0.9673235686951294 2.4280536739266068 0.20075999920208543 0.18028948153942373 113.39055645360597 1.0507567428948759 0.7876942612690598 32.62161403273619 0.029999906057360536 1.5228801052414647 1.4607301052314774 FES(ph)PESQASAEQPEM ddPTM_A459_Selumetinib_30min_R2 1 FESPESQASAEQPEM 15 0 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 FES(0.825)PES(0.102)QAS(0.073)AEQPEM 141.59 0.00038487 4189700.0 23216.0 18100.0 23653.0 24455.0 20867.0 19011.0 24249.0 18951.0 13814.0 20691.0 True False 21925.7476610115 19488.211799327033 22131.191731439205 21124.186812771954 18245.500906653102 21629.59268532449 25376.626548481934 19006.144272493064 16577.18599540921 20093.597068325784 1.0911808167773902 0.9698717324259956 1.101405171815919 1.0512894600673925 0.9080256185396542 1.0764420432924848 1.2629210420708579 0.9458806309226282 0.8249984280584779 1.0 14.294448231729625 -7.9826948539665095 24.996958400334883 0.903479197797656 1.0606872734909438 0.32067026639596297 0.09531598612910024 258.9977236522008 374117.1997915385 0.05302012997581323 0.025461897013594127 1.0406510961866097e-08 7.9826948539665095 0.15720807569328787 FES(ph)PEVAER ddPTM_A459_Selumetinib_30min_R1 1 FESPEVAER 9 0 A0A087X0X3;P52272-2;P52272 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 FES(1)PEVAER 94.363 0.023342 6868500.0 2589.1 2979.6 2821.9 2626.8 3247.3 2442.9 3395.4 3053.2 1458.5 2729.1 True False 2649.4209924883867 2630.7470468215406 2438.7014795871564 2168.078691142917 2953.5822883573805 2418.3266439757313 3139.2822443477776 2972.219217808685 2474.9679753746836 3079.4065686851422 0.8603673900779031 0.8543032523129377 0.7919387794994681 0.7040573054530607 0.9591400883510206 0.78532229831812 1.01944390074098 0.9651922055481538 0.8037158849185204 1.0 11.588436641133235 -6.896314122621252 1.6079961321718574 0.9378451556834939 0.8157007395348101 0.27674503349506996 0.08571595078831945 0.5130971124100059 2.7260769573532344 0.039399522467039684 0.03214714982262022 1.269655438772057e-07 6.896314122621252 -0.12214441614868377 FES(ph)PEVAER ddPTM_A459_Selumetinib_30min_R2 2 FESPEVAER 9 0 A0A087X0X3;P52272-2;P52272 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 FES(1)PEVAER;FES(1)PEVAER 110.84 0.006993600000000001 5019000.0 65278.0 63513.0 75589.0 71149.0 74021.0 50629.0 54988.0 62116.0 51367.0 64630.0 True False 61650.11008853848 68384.24287351707 70725.68603508045 61458.38346112903 64721.82022386391 57602.685185697424 57545.05095665493 62296.74727614263 61641.83531389783 62763.96397109347 0.982253289752891 1.0895462706117809 1.1268518041284616 0.9791985651102958 1.0311939547615596 0.917766844876574 0.9168485754525931 0.9925559721631664 0.9821214501730252 1.0 15.937648850734433 -6.156773579288934 1.9248298504219803 0.9630164126460402 1.0646730476416455 0.3881509772274485 0.04937739349706962 0.3265523147847905 2.3854144584882904 0.01692936009194634 0.02398926375726122 6.969897970928655e-07 6.156773579288934 0.10165663499560529 FESLEPEMNNQASR ddPTM_A459_Selumetinib_30min_R1 2 FESLEPEMNNQASR 14 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 ; 222.18 7.8585e-07 17700600.0 3088.9 3834.1000000000004 3451.8 3588.0 3841.4 3155.5 3401.8 2962.1 1766.72 2869.3999999999996 False True 3160.865360046881 3385.2017895752692 2983.0645193801856 2961.4231551015614 3493.946048254253 3123.758534964764 3145.1994871951088 2883.535485743188 2997.994803876561 3237.7154403228687 0.9762641029786348 1.0455525978026323 0.9213485787629042 0.9146644322782872 1.0791393229745456 0.9648032980481012 0.9714255453164425 0.8906080657463951 0.9259599427853356 1.0 11.66076047880313 -7.573072783858479 10.393327431124334 0.9310638097634263 0.9834361113077408 0.11886627224653579 0.0533063462233218 0.9065916716904234 181.7907199213097 0.025342167709903832 0.014621113197240052 2.672558474308587e-08 7.573072783858479 0.05237230154431449 FESPATGILS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 FESPATGILSPR 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 FESPATGILS(1)PR;FESPATGILS(1)PR;FESPATGILS(1)PR;FESPATGILS(1)PR 240.65 2.2943e-13 216970000.0 7785.0 8388.0 8423.1 8572.0 7968.4 7266.800000000001 8614.7 7755.7 4687.63 6538.5 True False 7966.375353026954 7405.929060524591 7279.28928477642 7075.061116368617 7247.659626935283 7193.702589726488 7964.88624326524 7549.993641935947 7954.565739050824 7377.780165383386 1.0797794423863782 1.0038153610585037 0.9866503367680856 0.9589688168759583 0.9823631857372723 0.9750497342655192 1.0795776052851997 1.0233421805329181 1.0781787422148632 1.0 12.848971086566022 -7.253051375633418 24.95976474249761 1.0472198142521592 0.9950762877285181 0.2768397849319365 0.03740823901186522 762.3896216119788 2268607.875507612 0.014625729387657134 0.011143278347160399 5.584041334254608e-08 7.253051375633418 -0.05214352652364107 FESPATGILS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 FESPATGILSPR 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 FES(0.002)PAT(0.009)GILS(0.989)PR;FESPATGILS(1)PR;FES(0.006)PAT(0.012)GILS(0.982)PR;FESPATGILS(1)PR;FESPATGILS(1)PR 145.09 0.00069261 48350300.0 58616.3 55948.0 65584.2 65114.5 74661.3 62074.0 65801.4 63943.2 58966.1 67780.0 True False 55358.64070564048 60239.031698825886 61364.58397467785 56245.79277122223 65281.68001350941 70624.13004833167 68861.29548300049 64129.26412563341 70760.96765049224 65823.01528641065 0.8410225582155825 0.9151667002295838 0.932266376854157 0.85450039817356 0.991775896765808 1.072939757333059 1.0461583259802 0.9742681013106532 1.07501862900986 1.0 16.00630449594049 -6.421637755354195 4.532328992763285 1.0329616147827825 0.8918901485567082 0.7720753234506817 0.037960579617128905 0.10982829253879654 3.735433643189347 0.011952298640223794 0.01348714441713195 3.7875837502642565e-07 6.421637755354195 -0.14107146622607425 FESPES(ph)QASAEQPEM ddPTM_A459_Selumetinib_30min_R2 2 FESPESQASAEQPEM 15 0 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 FES(0.175)PES(0.813)QAS(0.012)AEQPEM;FES(0.378)PES(0.619)QAS(0.003)AEQPEM 87.863 0.018219 3665400.0 25553.5 15602.2 20765.5 22628.7 21912.5 16191.5 27982.0 19516.9 14262.2 22499.5 True False 24133.33876876539 16798.838571019893 19429.470337766914 19546.63202331519 19159.655849764506 18421.73215319718 29283.218445281105 19573.690947803276 17115.03851916355 21849.88097427849 1.1045066468405464 0.7688297520153704 0.8892254543921376 0.8945875744735329 0.8768768979711653 0.8431044624400059 1.340200364466657 0.8958259759330164 0.7833012243550086 1.0 14.415337800314871 FFEHFIEGGR ddPTM_A459_Selumetinib_30min_R1 1 FFEHFIEGGR 10 0 J3KR44;F5H6Q1;F5GYJ8;Q96FW1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 123.11 0.0059782 9193500.0 5169.9 7003.5 5508.8 7152.9 6207.0 5676.5 5893.4 5335.9 2715.7 4734.0 False True 5290.348611125762 6183.526964161179 4760.735217672391 5903.780291562417 5645.577945934859 5619.399563849619 5448.856093196437 5194.374598554093 4608.344553119667 5341.655013064913 0.990395036404698 1.1576050772723379 0.8912472269415234 1.1052342910806907 1.0568967730275718 1.0519959731778603 1.0200688887375402 0.9724279433713721 0.8627184911508371 1.0 12.383071088225483 -7.8269995155412 2.854148571161205 0.9283084467239531 1.0431697943800984 0.26949386019663824 0.07282690459737226 0.32108005422522423 5.194964643064675 0.04439156259252913 0.01903680752034998 1.4893627391054605e-08 7.8269995155412 0.11486134765614531 FFPNDDPEAVS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 FFPNDDPEAVSSPR 14 0 F5H7T0;F6RJM5;Q96S38-2;Q96S38;A0A087X1U5 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 FFPNDDPEAVS(0.918)S(0.082)PR 160.63 0.00028926 2125500.0 11767.0 9800.9 9835.5 12992.0 12221.0 10369.0 11123.0 12730.0 9676.2 15228.0 True False 11113.037247033182 10552.59751513946 9202.694638082708 11222.467187549923 10685.688722873792 11797.235629589692 11640.241539806368 12767.042192435056 11611.71037561739 14788.328072904405 0.7514735399598556 0.7135761029317593 0.6222944603821812 0.758873290626548 0.7225758496967899 0.7977396478784455 0.787123566803603 0.8633188369567749 0.7851942639068641 1.0 13.852171334131395 -8.79240874259355 0.2769811253439766 1.0519782586822792 0.6734691202728345 0.773236230421025 0.045069185294305814 1.3775263845904473 0.27393414246046455 0.17197162753928347 0.07837261572903664 1.6128398944643396e-09 8.79240874259355 -0.3785091384094448 FFPNDDPEAVSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 FFPNDDPEAVSSPR 14 0 F5H7T0;F6RJM5;Q96S38-2;Q96S38;A0A087X1U5 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 FFPNDDPEAVS(0.058)S(0.942)PR 142.57 0.00054505 3074300.0 628.82 717.7 1090.5 863.72 923.18 738.75 906.23 872.37 530.6 652.39 True False 643.4702825292752 633.6713503503219 942.4160896877256 712.8875160324197 839.6785320006668 731.3188457313324 837.8723414900408 849.231913742881 900.3894465092962 736.1306113167338 0.8741251520274168 0.8608137477354179 1.2802294527624714 0.9684253107709532 1.1406651470432867 0.9934634350053797 1.1382115192728084 1.153642982220017 1.2231381668787673 1.0 9.523817955488017 -5.23282971157843 24.754545959696546 1.11027630087148 0.8674693177223318 0.5122781594665977 0.09551063888887901 487.52125027134025 421826.43798178365 0.0232286900640186 0.06143410793722568 5.850194273908329e-06 5.23282971157843 -0.24280698314914817 FFPNDDPEAVSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 FFPNDDPEAVSSPR 14 0 F5H7T0;F6RJM5;Q96S38-2;Q96S38;A0A087X1U5 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 FFPNDDPEAVS(0.344)S(0.656)PR 78.28699999999998 0.03841 1709300.0 7960.3 8484.4 8819.5 10282.0 11852.0 10838.0 9459.4 8789.6 10367.0 12955.0 True False 7517.8983936056975 9135.126198354154 8252.062971945546 8881.57386256068 10363.045801775652 12330.836122431589 9899.28084344551 8815.176280803387 12440.68967818207 12580.955488867658 0.5975617988838733 0.7261075048264364 0.6559170310432653 0.7059538419335161 0.8237089631980228 0.9801192074276561 0.7868465040040046 0.7006762156184048 0.9888509413446616 1.0 13.61895387463659 -3.2283481307437123 0.15049749040144325 1.0335164757968145 3.6845499645395266e-12 0.5916369498005309 0.08915287639112512 33.33982865081642 0.529066261189483 0.38211355187446383 6.940954543098428 0.0005910876279857838 3.2283481307437123 -1.0335164757931299 FFQGS(ph)QEFLASASASAER ddPTM_A459_Selumetinib_30min_R1 2 FFQGSQEFLASASASAER 18 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 FFQGS(0.992)QEFLAS(0.008)AS(0.001)ASAER;FFQGS(0.994)QEFLAS(0.005)ASASAER 190.25 4.3223999999999994e-15 4152600.0 669.92 701.6600000000001 751.66 777.2099999999999 765.8299999999999 655.94 823.99 875.94 324.0 433.71 True False 685.5278325625969 619.5093210071157 649.5887005728346 641.4848635385969 696.5608117182684 649.3418391458686 761.8357709018452 852.7072257458864 549.8043359762754 489.3809031931528 1.40080625968363 1.2659041596533298 1.327368306230065 1.310808941160114 1.4233510281526947 1.3268638700631543 1.556733754690787 1.742420311422191 1.1234691267862453 1.0 8.934813994898446 -6.259276492105283 23.254855508895844 1.4072266108326354 1.3219953864842642 0.0 0.1993209924585885 294.8063121943809 3169654.398029943 0.058562730864595666 0.07182951696039827 5.504571381609562e-07 6.259276492105283 -0.08523122434837127 FFQGS(ph)QEFLASASASAER ddPTM_A459_Selumetinib_30min_R2 3 FFQGSQEFLASASASAER 18 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 FFQGS(0.922)QEFLAS(0.043)AS(0.013)AS(0.022)AER;FFQGS(0.994)QEFLAS(0.006)ASASAER;FFQGS(1)QEFLASASASAER 197.28 2.4405e-10 8896800.0 24861.199999999997 17706.9 21659.4 21948.199999999997 25435.3 22938.9 18573.1 22810.2 18201.800000000003 24068.2 True False 23479.514031268922 19064.962293342734 20265.857784971657 18958.817297243153 22239.890219532936 26098.525256398392 19436.78595189946 22876.573905568115 21842.668600784662 23373.288529306403 1.0045447392577784 0.8156730820927611 0.867052052156096 0.8111317871882597 0.9515088213473956 1.1165962044097892 0.8315811413327143 0.9787486205411153 0.9345141387955492 1.0 14.512573109440458 -6.422001562147342 7.4390162661230335 0.9698743358915082 0.8704601189804628 0.24219813190302086 0.08211096503236284 0.3939977988498309 25.62192323405506 0.025213456233186035 0.028559056421883458 3.784412234701994e-07 6.422001562147342 -0.09941421691104535 FFQGSQEFLAS(ph)ASASAER ddPTM_A459_Selumetinib_30min_R1 2 FFQGSQEFLASASASAER 18 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 FFQGSQEFLAS(0.998)AS(0.002)ASAER;FFQGSQEFLAS(0.991)AS(0.002)AS(0.006)AER 195.28 2.8228e-10 23840000.0 3317.8 3861.1 3434.0 3671.9 3959.8 3244.3999999999996 3290.2 3844.8 1818.63 2853.8 True False 3395.098284685013 3409.04061702331 2967.681661611785 3030.6715950996177 3601.63678915947 3211.764281679505 3042.017565044782 3742.8234143295 3086.082282520168 3220.1130283660036 1.0543413398155788 1.0586711047075186 0.9216079173213646 0.941169321822683 1.1184814810637453 0.997407312534388 0.9446927912926107 1.1623267200122902 0.9583770058177593 1.0 11.652895613561364 -6.215533766062943 24.998892388197607 1.032414443640172 0.9934034761227557 0.053242697608503975 0.07456129886441157 1453.5137409763825 791541.5065701525 0.02221251890627614 0.028676129312672688 6.087882111047195e-07 6.215533766062943 -0.039010967517416395 FFTFDSPAELPS(ph)RTPR ddPTM_A459_Selumetinib_30min_R1 1 FFTFDSPAELPSRTPR 16 1 Q9NXH8 Q9NXH8 TOR4A Torsin-4A 1 FFTFDSPAELPS(0.764)RT(0.236)PR 100.07 0.0034153 11296000.0 3420.0 2977.9 4842.9 4644.7 4561.1 3663.0 3550.2 4002.7 2387.2 3026.0 True False 3499.6793458384323 2629.2460836118503 4185.260780145518 3833.590336817232 4148.549310327611 3626.1535457378955 3282.4055557175825 3896.535393398016 4050.9040458103855 3414.416575736045 1.0249714023497578 0.7700425607982717 1.2257616161681448 1.1227658523157287 1.2150097149271568 1.0620126353376216 0.961337166367872 1.1412009363731608 1.1864117795694373 1.0 11.737423369707606 -5.264249137090907 24.99988078345844 1.1159223355829433 0.8975069821483102 0.4285129179152305 0.10013629958279772 207.82345823676778 1849131.017608016 0.02588380235930632 0.05796492869454407 5.441903833803406e-06 5.264249137090907 -0.21841535343463314 FFTT(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 FFTTPSK 7 0 O76021;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 FFT(0.002)T(0.997)PS(0.001)K 146.23 0.0074255 306330000.0 16077.0 19539.0 20987.0 21019.0 17782.0 15481.0 16817.0 15178.0 8858.8 12461.0 True False 16451.562819603645 17251.364796565336 18137.080673339104 17348.42622549603 16173.621239667089 15325.275195623364 15548.48015055562 14775.430134907707 15032.736578847625 14060.490730418658 1.170056090859767 1.226939025623302 1.289932266311381 1.2338421580097634 1.150288531870147 1.0899530812582845 1.10582770179691 1.0508474005777295 1.0691473624263765 1.0 13.77935932687502 -6.617534185255834 1.6484841705343287 1.0608232702512388 1.2355866120669747 0.8233443281127067 0.036659842199119864 0.15606177527215886 0.872218595209295 0.015471352702919865 0.01576134792543061 2.4124916271407286e-07 6.617534185255834 0.17476334181573594 FFTT(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 FFTTPSK 7 0 O76021;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 FFT(0.04)T(0.96)PSK;FFT(0.032)T(0.893)PS(0.074)K 131.62 0.0090662 406250000.0 369270.0 373700.0 355840.0 380550.0 350800.0 282240.0 340470.0 317540.0 283860.0 375650.0 True False 348747.451704933 402361.5883651102 332945.6418092986 328718.4335146334 306729.36780820985 321115.99808037333 356302.5296285058 318463.9888284232 340639.9317110797 364804.00844408665 0.9559857995869182 1.1029527610763081 0.9126699106989912 0.9010822959885758 0.8408059141576624 0.880242515563232 0.9766957637010618 0.8729728332391228 0.9337614824023773 1.0 18.476762056271248 -5.329252378162669 10.012849592196332 0.9079834206642509 1.0293463363255881 0.3983809515161283 0.05588229151556832 0.44302808919430203 63.7683353504204 0.013989616079938596 0.029172926226994488 4.685410234280261e-06 5.329252378162669 0.12136291566133728 FFVS(ph)TPSQPSCK ddPTM_A459_Selumetinib_30min_R2 2 FFVSTPSQPSCK 12 0 H0YLN8;Q96QT4 H0YLN8 TRPM7 Transient receptor potential cation channel subfamily M member 7 1 FFVS(0.756)T(0.229)PS(0.015)QPSCK;FFVS(0.49)T(0.49)PS(0.018)QPS(0.001)CK 136.33 0.0014159 10359200.0 85254.0 26696.0 59991.0 70337.0 34307.0 38361.0 97890.0 66555.0 53184.0 46719.0 True False 80515.92397880238 28743.49735883061 56131.24437326216 60756.97926190729 29997.04795152862 43644.87954351336 102442.07896535525 66748.66403122667 63822.28608511969 45370.101079460284 1.774647225003718 0.6335339061398568 1.2371857905926862 1.339141368794809 0.6611633485010843 0.9619744833072906 2.2579204482251485 1.4712037761239367 1.4067036344781911 1.0 15.469454253403274 FGDES(ph)PLLTMR ddPTM_A459_Selumetinib_30min_R1 2 FGDESPLLTMR 11 0 H0YJ41;Q9P203-5;Q9P203 H0YJ41 BTBD7 BTB/POZ domain-containing protein 7 1 FGDES(0.998)PLLT(0.002)MR;FGDES(0.999)PLLT(0.001)MR 126.34 0.0031766 7373100.0 2687.7 3579.6 2885.2 3501.4 3822.0 2875.8 3366.5 3235.0 2051.0 3070.1000000000004 True False 2750.3181806461835 3160.4987678891066 2493.405687269167 2889.9462194182315 3476.3007748289047 2846.872063017482 3112.5621946153015 3149.1972912390593 3480.3972008868554 3464.177240306419 0.7939311385819589 0.9123374898709135 0.7197685090294677 0.8342374015374009 1.0034996865580161 0.821803235092459 0.8984996952234419 0.9090751057992925 1.0046821970861404 1.0 11.75829703030687 -7.465089642349138 0.40773802690722516 1.011985644691534 0.8074959308497495 0.4358650839965146 0.06926208316706411 1.1824045323357064 0.4886211579195367 0.0797417303043213 0.08057869406876683 3.426970434447598e-08 7.465089642349138 -0.2044897138417846 FGDFLQHS(ph)PSILQSK ddPTM_A459_Selumetinib_30min_R1 2 FGDFLQHSPSILQSK 15 0 Q96Q89-5;Q96Q89-3;Q96Q89;Q96Q89-2 Q96Q89-5 KIF20B Kinesin-like protein KIF20B 1 FGDFLQHS(0.856)PS(0.143)ILQSK;FGDFLQHS(0.985)PS(0.015)ILQSK 99.092 0.0055952 47556000.0 9950.7 11235.0 12283.400000000001 12258.0 11021.8 10488.1 11679.7 9523.099999999999 5012.5 8408.3 True False 10182.531949308328 9919.600976990203 10615.381747886491 10117.370411158017 10024.880136056838 10382.59923643287 10798.690825619584 9270.516452611657 8505.846401484818 9487.587208777713 1.0732477842087889 1.0455346294801695 1.1188705320216046 1.066379701026373 1.056631145037806 1.0943350514688404 1.138191469336784 0.9771205522131878 0.8965236592097293 1.0 13.211825526333051 -7.902072804228692 5.842449527872794 0.9447567742675004 1.0827447084101485 0.7334942229519448 0.035246722408445126 0.09704936387259844 4.755991425942753 0.019330531477919414 0.00909245435284304 1.2529311185539302e-08 7.902072804228692 0.1379879341426481 FGDFLQHS(ph)PSILQSK ddPTM_A459_Selumetinib_30min_R2 2 FGDFLQHSPSILQSK 15 0 Q96Q89-5;Q96Q89-3;Q96Q89;Q96Q89-2 Q96Q89-5 KIF20B Kinesin-like protein KIF20B 1 FGDFLQHS(0.904)PS(0.096)ILQSK;FGDFLQHS(0.941)PS(0.059)ILQSK 85.49600000000002 0.013665 10775900.0 61630.0 61269.0 64341.0 62974.0 73654.0 60585.0 51027.0 55510.0 43416.0 66500.0 True False 58204.85132443741 65968.1352891142 60201.370109184005 54396.8325637907 64400.92604488552 68930.03381412785 53399.8566080823 55671.524909824795 52100.41314439595 64579.97221224997 0.9012833132405207 1.021495256645541 0.9321987614259858 0.8423173733337769 0.9972275279590398 1.0673592981362838 0.826879522843044 0.8620555723816902 0.8067580607368732 1.0 15.978799199732409 -7.29688404652534 24.995242176547748 0.8624279133597313 0.9581311226085923 0.23006152745416797 0.07621048242773998 858.5778647743999 605457.5316845238 0.031968517898307756 0.02155423855077287 5.0479605645628586e-08 7.29688404652534 0.095703209248861 FGESEEVEMEVES(ph)DEEDDKQEK ddPTM_A459_Selumetinib_30min_R1 13 FGESEEVEMEVESDEEDDKQEK 22 1 Q15459;Q15459-2;H7C1L2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGES(0.002)EEVEMEVES(0.998)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK 143.48 1.7511e-06 518069500.0 40583.26 44574.78999999999 40086.86 35261.130000000005 28067.100000000002 39013.6 38945.49 42786.509999999995 30833.350000000002 45710.520000000004 True False 41528.7709967225 39355.952864542305 34643.28459336019 29103.43557888693 25528.43576064899 38621.1586055146 36007.80033410611 41651.672764628434 52321.94297121632 51577.91050016984 0.8051658276576704 0.7630389149714142 0.6716690198849005 0.5642616247277232 0.494949010401748 0.7487926174401235 0.698124448720883 0.8075486649365387 1.0144254093240948 1.0 15.654465708083647 -8.04965479490179 1.9039991572750878 1.0193650971334065 0.6683331291948654 0.6899901145106895 0.0874812120195065 0.21940234269732123 1.427077241198685 0.0851834039455779 0.027520108046732047 8.919596431450697e-09 8.04965479490179 -0.3510319679385411 FGESEEVEMEVES(ph)DEEDDKQEK ddPTM_A459_Selumetinib_30min_R2 11 FGESEEVEMEVESDEEDDKQEK 22 1 Q15459;Q15459-2;H7C1L2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 FGESEEVEMEVES(1)DEEDDKQEK;FGES(0.001)EEVEMEVES(0.999)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGES(0.003)EEVEMEVES(0.997)DEEDDKQEK;FGES(0.001)EEVEMEVES(0.999)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGES(0.003)EEVEMEVES(0.997)DEEDDKQEK;FGESEEVEMEVES(1)DEEDDKQEK;FGES(0.03)EEVEMEVES(0.97)DEEDDKQEK 110.89 2.5638e-05 134383200.0 418700.6 353159.8 322581.8 310813.3 272534.89999999997 228281.4 329471.0 302922.9 191979.1 282171.60000000003 True False 395430.89684330276 380246.02107226336 301827.2381885073 268479.9923571515 238296.6293690812 259725.09071777592 344792.05433440127 303804.35548741434 230380.28434423465 274024.57273813745 1.44304904079235 1.387634755791164 1.101460482804725 0.9797661197841392 0.869617738978473 0.94781678928471 1.2582523198161883 1.108675592308048 0.8407285596404888 1.0 18.063945744914214 -5.3003275317293195 2.7609277004234847 1.0089963143928251 1.4386807543222713 0.6819879047891162 0.11180161843500616 0.17077934708656783 2.5350642348881927 0.03317053507461475 0.09641021748542546 5.008093959077479e-06 5.3003275317293195 0.42968443992944616 FGEYNSNMS(ph)PEEK ddPTM_A459_Selumetinib_30min_R1 5 FGEYNSNMSPEEK 13 0 E9PFK5;P78316-2;P78316 E9PFK5 NOP14 Nucleolar protein 14 1 FGEYNS(0.089)NMS(0.911)PEEK;FGEYNS(0.001)NMS(0.999)PEEK;FGEYNS(0.065)NMS(0.935)PEEK;FGEYNS(0.036)NMS(0.964)PEEK;FGEYNS(0.001)NMS(0.999)PEEK 241.41 6.8476e-18 215637000.0 15901.8 21752.4 21768.8 23552.100000000002 17006.2 18023.800000000003 17880.6 15868.800000000001 10237.859999999999 15952.699999999997 True False 16272.281000483503 19205.618895583597 18812.71652745911 19439.167862672108 15467.992212688478 17842.496936301042 16531.85194624636 15447.907874873083 17372.900676290337 18000.38443745684 0.9039963039135241 1.0669560398731706 1.0451285967155177 1.0799307053810092 0.8593145477771725 0.9912286594931133 0.9184166040279326 0.8581987750621408 0.9651405355620751 1.0 14.135740098331613 -6.255706414277302 24.99919571754021 0.927237070031404 1.02857996869057 0.3330678978269509 0.06339414068836838 508.0800370482892 2215534.3828287027 0.018430439062015982 0.023167921417754492 5.55000770084028e-07 6.255706414277302 0.1013428986591659 FGEYNSNMS(ph)PEEK ddPTM_A459_Selumetinib_30min_R2 8 FGEYNSNMSPEEK 13 0 E9PFK5;P78316-2;P78316 E9PFK5 NOP14 Nucleolar protein 14 1 FGEYNS(0.004)NMS(0.996)PEEK;FGEYNS(0.021)NMS(0.979)PEEK;FGEYNS(0.142)NMS(0.858)PEEK;FGEYNS(0.049)NMS(0.951)PEEK;FGEYNSNMS(1)PEEK;FGEYNSNMS(1)PEEK;FGEYNS(0.108)NMS(0.892)PEEK;FGEYNS(0.005)NMS(0.995)PEEK 189.8 0.00015892 178991300.0 365664.0 367985.0 353225.0 354363.0 336649.0 282138.0 335020.0 319489.0 243749.6 327679.0 True False 345341.8587489712 396208.2662417318 330498.8880623015 306098.148089728 294356.14293975435 320999.9485062378 350599.09382953594 320418.66009574913 292506.33093286445 318218.0558577124 1.0852365300835942 1.2450841771809826 1.0385925059201553 0.9619131990002363 0.9250139566919244 1.00874209554523 1.10175738735046 1.00691539715465 0.9192009238584983 1.0 18.279656171693915 -5.442895422138769 5.590634347260639 0.9926354757038176 1.1633995033660607 0.5706115914372669 0.060181670464970194 0.15811854084304175 8.31929001052005 0.016422591645741513 0.03460184531167124 3.606654806061072e-06 5.442895422138769 0.17076402766224308 FGGEHVPNS(ph)PFQVTALAGDQPSVQPPLR ddPTM_A459_Selumetinib_30min_R1 1 FGGEHVPNSPFQVTALAGDQPSVQPPLR 28 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5F3 P21333-2 FLNA Filamin-A 1 FGGEHVPNS(0.925)PFQVT(0.075)ALAGDQPSVQPPLR 59.661 0.0031154 26945000.0 1992.0 2216.7 2457.0 2688.4 2116.9 1878.5 2014.1 1613.5 1269.8 1467.3 True False 2038.4097242427358 1957.167733484129 2123.3528953349305 2218.9214075181276 1925.42676876905 1859.603995541533 1862.1748154387865 1570.7047386133615 2154.7578574773916 1655.6422477123263 1.2311897253523798 1.1821199514499185 1.2824949944765305 1.3402179188071028 1.1629485605537653 1.1231919203022451 1.1247446832260022 0.9486981506926834 1.3014634414256554 1.0 10.693175252662453 -6.55253141371948 3.3389828943807975 1.0981589613360037 1.2555540960613534 0.3846811930608609 0.09444571441538237 0.25852251882321625 6.019049143475112 0.03130915581496156 0.03261534703440088 2.802002937724339e-07 6.55253141371948 0.15739513472534972 FGGEHVPNS(ph)PFQVTALAGDQPSVQPPLR ddPTM_A459_Selumetinib_30min_R2 2 FGGEHVPNSPFQVTALAGDQPSVQPPLR 28 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5F3 P21333-2 FLNA Filamin-A 1 FGGEHVPNS(0.955)PFQVT(0.045)ALAGDQPSVQPPLR;FGGEHVPNS(0.998)PFQVT(0.002)ALAGDQPSVQPPLR 86.32 1.9541e-05 8454900.0 52344.0 50283.0 52656.0 54898.0 55838.0 42552.0 38341.0 43236.0 39934.0 48450.0 True False 49434.930029634124 54139.54441467189 49268.170287518 47420.79769566773 48823.13124194645 48413.151751403304 40123.9324712502 43361.8096018949 47921.91584918713 47051.12261178214 1.0506641985467748 1.1506536169471697 1.0471199740339603 1.0078568812679725 1.037661346463189 1.0289478563744214 0.8527731166440374 0.9215892670547376 1.0185073849266018 1.0 15.521941524758939 -6.277519061272017 0.9124996180070033 0.9488625762483847 1.0961647503513448 0.44896648720168875 0.05586043426976421 0.524937826071323 0.9348569804171061 0.028901469660597135 0.045844499906706665 5.27814040408974e-07 6.277519061272017 0.1473021741029601 FGGPVHHQAQR ddPTM_A459_Selumetinib_30min_R1 1 FGGPVHHQAQR 11 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 91.265 0.015037 2085700.0 2587.3 3130.8 2723.7 2754.5 2805.4 2392.1 2197.3 2556.1 1512.9 2323.3 False True 2647.579055990577 2764.244480530567 2353.8365002131673 2273.4782833687996 2551.652065333599 2368.0376458530222 2031.5558919436216 2488.3039246170506 2567.2808021558876 2621.5181858584124 1.0099411365035529 1.0544441367761939 0.8978905860393285 0.8672372732842029 0.9733489849882785 0.9033077316141569 0.7749539571774482 0.9491843077953926 0.9793106971391218 1.0 11.356186838739411 -5.264109937065631 24.960440968471627 0.9108476000684274 1.032192642220665 0.33981180923202836 0.06292488375025601 224.89524868492242 2102014.211940784 0.016667451706443813 0.03747683615671997 5.443648351854586e-06 5.264109937065631 0.12134504215223774 FGGPVHHQAQR ddPTM_A459_Selumetinib_30min_R2 1 FGGPVHHQAQR 11 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 131.62 0.0012232 3464900.0 17659.0 15738.0 16680.0 19308.0 20428.0 17616.0 16632.0 18985.0 17114.0 18234.0 False True 16677.58347457797 16945.053994354075 15606.82695981085 16678.217091842198 17861.65201136289 20042.44409787367 17405.420955682777 19040.24320686405 20537.278205113165 17707.537042378455 0.9418353006781487 0.9569401974876816 0.8813663313232047 0.9418710830268013 1.0087033543183108 1.1318595042273363 0.9829385596668446 1.0752620853648986 1.1598043339377153 1.0 14.112075939812584 -6.410691771745209 3.1714564250888904 1.0695162734047277 0.9283748648515474 0.6025843171987227 0.053117889474498164 0.17804824978862688 3.3921292265704337 0.01740658888746575 0.019775730522426045 3.884259425409125e-07 6.410691771745209 -0.14114140855318025 FGGS(ph)GSQVDSAR ddPTM_A459_Selumetinib_30min_R1 2 FGGSGSQVDSAR 12 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 FGGS(0.433)GS(0.4)QVDS(0.167)AR;FGGS(0.826)GS(0.174)QVDSAR 111.66 0.006704000000000001 25341000.0 2087.3 2465.0 2032.5700000000002 2256.37 2239.7 2161.82 2308.61 2302.0 1277.81 1692.0500000000002 True False 2135.9300288212157 2176.3966540525894 1756.5581581078234 1862.3373368106227 2037.1195304511505 2140.0740535755117 2134.4696890274245 2240.9434820501747 2168.3502424501366 1909.2410994627132 1.1187324793198177 1.1399276155667597 0.9200295125650412 0.9754332951111885 1.0669786707527007 1.120902988196597 1.1179675996017966 1.1737351991222098 1.1357131600929502 1.0 10.89878358281309 -6.637971578562422 4.011134037556984 1.1210336867854183 1.0357183227622018 0.16723998786476746 0.07248778524684246 0.36589785704507694 10.833047129076107 0.026253191983610553 0.026121901165032973 2.3015924350839338e-07 6.637971578562422 -0.08531536402321649 FGGS(ph)GSQVDSAR ddPTM_A459_Selumetinib_30min_R2 4 FGGSGSQVDSAR 12 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 FGGS(0.987)GS(0.013)QVDSAR;FGGS(0.668)GS(0.332)QVDSAR;FGGS(0.943)GS(0.057)QVDSAR;FGGS(0.986)GS(0.014)QVDSAR 201.08 8.4836e-05 33914100.0 85700.0 76718.0 88380.0 87412.0 98755.0 72869.0 71720.0 81300.0 71715.0 80006.0 True False 80937.13708428183 82602.02391274965 82693.72702086839 75506.33480588933 86348.51401909854 82906.0433110783 75055.12211048392 81536.56954006055 86060.00388452086 77696.01889944759 1.041715370114765 1.0631435829376443 1.0643238635931749 0.971817293542516 1.1113634294551027 1.0670565169931474 0.9660098827923029 1.049430468832429 1.107650110051298 1.0 16.24555305718927 FGITSAFSMLY(ph)VFTAELY(ph)PTLVR ddPTM_A459_Selumetinib_30min_R2 1 FGITSAFSMLYVFTAELYPTLVR 23 0 Q9H015 Q9H015 SLC22A4 Solute carrier family 22 member 4 2 FGIT(0.003)S(0.003)AFS(0.02)MLY(0.969)VFT(0.086)AELY(0.644)PT(0.274)LVR 43.823 0.043671 0.0 3527.2 4063.1 5448.2 5130.8 7853.7 2979.3 4287.2 4375.5 3029.3 4788.4 True False 3331.1723445003336 4374.726705074345 5097.668743551647 4431.976188876317 6867.047993031175 3389.6715316073464 4486.563294925635 4388.231980596979 3635.244645713996 4650.146450242677 0.7163585878733969 0.940771812648189 1.0962383224050105 0.9530831418535272 1.4767380052455776 0.728938662013634 0.9648219347353018 0.943676081506631 0.7817484211759145 1.0 12.183060437379911 FGQAAT(ph)MEGIGAIGGTPPAFNR ddPTM_A459_Selumetinib_30min_R2 1 FGQAATMEGIGAIGGTPPAFNR 22 0 Q15233-2;Q15233 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 1 FGQAAT(0.636)MEGIGAIGGT(0.364)PPAFNR 77.279 0.016163999999999998 12873000.0 22490.0 20452.0 23575.0 32060.0 23976.0 21289.0 24020.0 22476.0 17326.0 24017.0 True False 21240.095834603246 22020.60263645505 22058.210166519228 27693.372693415226 20963.920531840467 24221.36650769938 25136.977594727046 22541.40143889791 20791.684128888064 23323.56680633998 0.910670996891848 0.9441352953986973 0.9457477215930459 1.1873558158303392 0.8988299562373069 1.0384932419991333 1.077750148742007 0.9664645903460419 0.8914453051510252 1.0 14.509500812184392 -5.549762978074436 24.999450707953628 1.0113714694427947 0.9317874003018924 0.15379070587859944 0.08118152374754514 380.8073301069238 354108.15107555233 0.02196647504473297 0.03804817868112178 2.8199215206325215e-06 5.549762978074436 -0.07958406914090221 FGQAATMEGIGAIGGT(ph)PPAFNR ddPTM_A459_Selumetinib_30min_R1 7 FGQAATMEGIGAIGGTPPAFNR 22 0 Q15233-2;Q15233 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 1 FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAAT(0.001)MEGIGAIGGT(0.999)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR 226.11 6.5174e-30 547984000.0 11414.86 12632.249999999998 14022.9 15427.2 14008.1 10683.659999999998 13223.1 11130.94 6836.98 10111.43 True False 11680.804028548908 11153.260297426299 12118.667202276021 12733.129124409936 12741.069828330925 10576.19208038715 12225.670921021117 10835.711312811281 11601.855706737882 11409.330534168772 1.023793989802217 0.9775560681693294 1.0621716292628145 1.1160277183903682 1.116723701725868 0.9269774461098721 1.0715502442853735 0.9497236740017646 1.016874361908662 1.0 13.477926520573908 -6.756393144975021 24.99993470614557 0.9947906959448116 1.0580319184867295 0.284573251899252 0.05245047012365682 190.4277579060647 943412.3791289652 0.018486954713281385 0.017942994822197435 1.7522935203560606e-07 6.756393144975021 0.06324122254191789 FGQAATMEGIGAIGGT(ph)PPAFNR ddPTM_A459_Selumetinib_30min_R2 10 FGQAATMEGIGAIGGTPPAFNR 22 0 Q15233-2;Q15233 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 1 FGQAATMEGIGAIGGT(1)PPAFNR;FGQAAT(0.366)MEGIGAIGGT(0.634)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAAT(0.122)MEGIGAIGGT(0.878)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR;FGQAATMEGIGAIGGT(1)PPAFNR 250.42 3.9371999999999997e-44 190584400.0 164271.9 167041.40000000002 180202.3 215228.9 197670.8 148295.59999999998 157503.5 169070.09999999998 143999.59999999998 189347.9 True False 155142.3254305185 179852.93825724316 168608.28020742943 185914.35252943874 172837.62690462658 168721.9728065755 164827.72483726454 169562.0659999383 172803.5436849952 183880.9341420733 0.843710774879193 0.9780945430605766 0.9169426998731492 1.0110583427088442 0.9399431632813315 0.9175609945303769 0.8963828991096623 0.9221296747868829 0.939757808449465 1.0 17.48841237482486 -12.468540551021858 1.3544021776726218 2.303312733046074 0.9317303605433389 0.19669498276887776 0.04252400471315384 971319.9757333854 21260.29731006246 3887685.417122144 0.011802301060290666 3.3998475920436734e-13 12.468540551021858 -1.3715823725027352 FGS(ph)NINLEADES ddPTM_A459_Selumetinib_30min_R1 2 FGSNINLEADES 12 0 Q9NQP4 Q9NQP4 PFDN4 Prefoldin subunit 4 1 FGS(1)NINLEADES;FGS(0.997)NINLEADES(0.003) 106.29 0.008962799999999998 7559200.0 3784.0 4633.299999999999 5244.299999999999 5513.0 3465.2 4190.1 4368.0 3941.7 2546.7 4124.7 True False 3872.159837617723 4090.831082037267 4532.152864877888 4550.258041826898 3151.7732718307493 4147.951398306405 4038.5182433030245 3837.153311553942 4321.563896391299 4654.145422980324 0.8319808441091106 0.8789650322996712 0.9737884086087888 0.9776785270523626 0.677196990078682 0.8912380300420925 0.8677249798346273 0.8244592643383254 0.9285407961369515 1.0 12.184300574420131 -11.412154549515328 6.320630273298815 1.0255614661215866 0.8719344073457762 0.1795074468545077 0.08183700666382082 0.03169968216489153 0.0005553115439603086 0.08521042067124207 0.01959698786035042 3.871198586135053e-12 11.412154549515328 -0.1536270587758104 FGS(ph)TLQLDLEK ddPTM_A459_Selumetinib_30min_R1 2 FGSTLQLDLEK 11 0 E5RIQ4;E5RIK1;A0A0D9SF44;A0A0R4J2E2;Q9Y3T6-3;Q9Y3T6 E5RIQ4 R3HCC1 R3H and coiled-coil domain-containing protein 1 1 FGS(0.5)T(0.5)LQLDLEK;FGS(0.911)T(0.089)LQLDLEK 184.96 2.2195e-05 28090000.0 4070.6 5262.9 5321.2 5872.0 3981.1 5193.5 4435.2 4431.6 2977.53 4653.5 True False 4165.437059991201 4646.717221344168 4598.610267259355 4846.5654310915215 3621.010207920292 5141.2581053207105 4100.649293199992 4314.059572134474 5052.650939813083 5250.82205392851 0.7932923677873912 0.8849504274988012 0.8757886327187208 0.9230107936081102 0.6896082500474681 0.9791339436982391 0.7809537727777324 0.8215969857342285 0.9622590306660341 1.0 12.358327589399867 -8.375998803782654 4.283447658516179 0.9967115468868132 0.8461169723902343 0.34475530588100567 0.07639768542034779 0.24370746349206304 6.9383881125111335 0.069175747764496 0.018210728883073676 4.2072778723219595e-09 8.375998803782654 -0.15059457449657887 FGS(ph)TLQLDLEK ddPTM_A459_Selumetinib_30min_R2 2 FGSTLQLDLEK 11 0 E5RIQ4;E5RIK1;A0A0D9SF44;A0A0R4J2E2;Q9Y3T6-3;Q9Y3T6 E5RIQ4 R3HCC1 R3H and coiled-coil domain-containing protein 1 1 FGS(0.981)T(0.019)LQLDLEK;FGS(0.971)T(0.029)LQLDLEK 132.97 0.0019106 6146200.0 45825.0 31062.4 38311.0 30242.0 33692.0 35867.0 27851.0 32066.0 20375.3 34965.0 True False 43278.22995200947 33444.786198641734 35846.1119698629 26122.987429640136 29459.30974969839 40807.35368179123 29146.126685709536 32159.306751187927 24450.929333448752 33955.469600019875 1.2745584279000557 0.9849602020707191 1.0556800536736477 0.7693307657752094 0.86758658020978 1.2017902907096696 0.8583632336421133 0.9471023999965268 0.720088092477285 1.0 15.051356364306518 -3.7387802246919857 1.1284295991418345 0.9208708184023411 3.983908287139922 0.3888027629744262 0.1310765293018349 15.461592546355748 2.660432184370032 0.03994564088084285 96.80417404310471 0.0001824818920776755 3.7387802246919857 3.0630374687375808 FGSTGS(ph)TPPVSPTPSER ddPTM_A459_Selumetinib_30min_R2 1 FGSTGSTPPVSPTPSER 17 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 FGS(0.044)T(0.01)GS(0.785)T(0.161)PPVSPTPSER 86.214 0.0113 9965700.0 32772.0 29133.0 41008.0 42682.0 44206.0 33461.0 31627.0 28348.0 23788.0 34989.0 True False 30950.663436710405 31367.40742264058 38369.5899261345 36868.63796944317 38652.44707334582 38069.94902128468 33097.71816771157 28430.48798673598 28546.264692253804 33978.77665766038 0.9108822177014044 0.9231470496619224 1.129222229296599 1.0850490098833878 1.137546753456522 1.1204037568757483 0.9740703292874383 0.8367131128108592 0.8401204369380426 1.0 15.052346291468362 -7.54141313459839 5.005106838986356 0.8810604742078022 1.0541690405329884 0.4064713812299827 0.08575756608010376 0.18444179193690463 12.798053538840916 0.04421455297836108 0.025900803899032432 2.8746625116784524e-08 7.54141313459839 0.17310856632518623 FGSTGST(ph)PPVSPTPSER ddPTM_A459_Selumetinib_30min_R1 1 FGSTGSTPPVSPTPSER 17 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 FGST(0.001)GS(0.056)T(0.914)PPVS(0.029)PT(0.001)PSER 102.63 0.0081992 9344100.0 2316.2 2377.9 2699.9 3193.6 2425.7 1989.6 2307.1 2189.1 1313.6 2368.5 True False 2370.1629534593485 2099.4943625442806 2333.268409489125 2635.897711296642 2206.2958632921172 1969.5864304122629 2133.073589543133 2131.0379568010603 2229.0832584519603 2672.5200461436953 0.8868644247886439 0.7855860110661246 0.8730592733461093 0.9862967034055001 0.8255488547132454 0.7369772336242236 0.7981506416092351 0.7973889512544667 0.8340754119574928 1.0 11.383985054072262 -6.495701840770341 24.975504877485022 0.8143245615277124 0.879119381127918 0.06671381432835888 0.07856759166007253 1510.2485671413515 1387916.0440622123 0.02408412255355327 0.027231336939778295 3.1937297162281624e-07 6.495701840770341 0.06479481960020561 FGSTGST(ph)PPVSPTPSER ddPTM_A459_Selumetinib_30min_R2 1 FGSTGSTPPVSPTPSER 17 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 FGS(0.001)T(0.007)GS(0.193)T(0.753)PPVS(0.044)PT(0.001)PSER 110.84 0.0048854 9254300.0 28330.0 28424.0 27254.0 32993.0 38632.0 26272.0 26214.0 22487.0 24258.0 30156.0 True False 26755.532013975542 30604.029402434884 25500.50731191157 28499.29648390045 33778.70278553804 29890.729526529125 27433.002942055577 22552.433447076735 29110.277825151028 29285.317925302414 0.9136158972977669 1.0450297818345728 0.8707608152643349 0.973159880203218 1.1534347303893653 1.0206728710533697 0.9367493640338307 0.7700935159591186 0.9940229400753696 1.0 14.837889936170944 -8.494245059092648 24.996302168028027 1.000000641503348 0.9629523405086738 0.02164097817804911 0.09760665186443675 3518.1263302837488 3071215.6870452818 0.10053570914822638 0.025958208431150532 3.2044606351358073e-09 8.494245059092648 -0.037048300994674155 FGT(ph)FGGLGSK ddPTM_A459_Selumetinib_30min_R1 1 FGTFGGLGSK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 FGT(1)FGGLGSK 120.55 0.011818 71439000.0 4492.8 5077.5 4606.1 4262.5 2017.5 4591.6 2807.9 2703.4 3091.5 2554.3 True False 4597.473498533014 4483.023939534292 3980.616919496223 3518.134392034672 1835.0174812185553 4545.4126728392375 2596.09784234674 2631.6970501192204 5246.049705773627 2882.1692859889536 1.5951434639466333 1.5554339439142417 1.381118360690032 1.2206550146576491 0.6366792853352155 1.5770803939018379 0.9007443993547193 0.9130959319123446 1.8201740374086177 1.0 11.492939360245591 -5.583767033036348 2.4622410801172365 1.133041472784913 1.5718112377010094 0.2207198172753264 0.3226262998470707 0.42430563327044657 5.154256921262162 0.09055772561259713 0.1964872240891323 2.6075519342261e-06 5.583767033036348 0.4387697649160964 FHALS(ph)SPQSPFPSTPTSR ddPTM_A459_Selumetinib_30min_R2 1 FHALSSPQSPFPSTPTSR 18 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 FHALS(0.54)S(0.458)PQS(0.002)PFPSTPTSR 58.107 0.038212 6114000.0 21456.0 18982.0 26536.0 24646.0 31218.0 17439.0 21288.0 16446.0 18910.0 24831.0 True False 20263.561415173284 20437.858363250023 24828.702650212257 21289.17228327858 27296.11574753901 19841.063954519686 22277.93418137174 16493.855137218125 22692.528389545965 24114.06451131399 0.8403212741537578 0.8475492944650976 1.0296357396971783 0.8828529206799621 1.1319583114962657 0.8228004841411338 0.923856456090977 0.6839931579962155 0.9410495015843945 1.0 14.557587222364718 FHALSS(ph)PQSPFPSTPTSR ddPTM_A459_Selumetinib_30min_R2 1 FHALSSPQSPFPSTPTSR 18 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 FHALS(0.226)S(0.765)PQS(0.008)PFPSTPTSR 57.39 0.039952 6098100.0 21378.0 19621.0 21198.0 20716.0 30652.0 17839.0 19237.0 17610.0 20667.0 22131.0 True False 20189.896342914533 21125.867608541193 19834.143758637307 17894.44506290673 26801.221727643217 20296.160323681208 20131.558617392337 17661.24218450755 24800.977484227733 21492.020526756452 0.9394135985390093 0.9829633087424509 0.9228608233434742 0.8326087833681841 1.2470312735034421 0.9443579443083789 0.9366992085425188 0.8217581107611646 1.1539621160026252 1.0 14.391513500607527 FHDFDHR ddPTM_A459_Selumetinib_30min_R1 4 FHDFDHR 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3;K7EII0;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 0 ;;; 154.35 0.0024193 52855900.0 6475.8 8434.6 8716.4 9317.3 8567.7 7453.5 7598.099999999999 6442.1 4405.16 6555.400000000001 False True 6626.673540286701 7447.073110860844 7532.760755757991 7690.208462382321 7792.753047750295 7378.5245572365275 7024.969199734594 6271.2345811100895 7475.234779843364 7396.849445003327 0.8958778449604797 1.0067898726655096 1.0183742161801703 1.0396599957265809 1.0535232744279264 0.9975226090644338 0.9497245079768465 0.847825094688982 1.0105971245491534 1.0 12.852695196224671 -7.263673687054993 4.600363630016067 0.93854908204946 1.007424041913828 0.13618020930582475 0.05746054646477173 0.2997277021991117 17.6036797992098 0.02390498473090289 0.016909817283014054 5.449119259020757e-08 7.263673687054993 0.06887495986436809 FHDFDHR ddPTM_A459_Selumetinib_30min_R2 2 FHDFDHR 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3;K7EII0;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 0 ; 134.06 0.0042408 8975200.0 45666.0 33285.0 42165.0 25956.0 40648.0 34001.0 28003.0 38745.0 23367.0 29520.0 False True 43128.06653548203 35837.85247185633 39452.14980578086 22420.748023402528 35541.4348422694 38684.32911965275 29305.19498689181 38857.74153541998 28041.05292853097 28667.68089782886 1.5044142108735528 1.2501134151584092 1.3761890941366226 0.7820914465774089 1.239773631112279 1.349405599201521 1.0222380767853192 1.3554546555024218 0.9781416581434969 1.0 14.80713758051689 -4.849701067392573 1.3935790548033917 1.1391038855769828 1.6010088100387012 0.28220919724942795 0.18323167591522582 1.5265120704727857 2.9513538974957703 0.05235223039819313 0.9636924002796934 1.4135101540031536e-05 4.849701067392573 0.4619049244617184 FHDT(ph)SSPLLISGTSAAELPWAVKPEDK ddPTM_A459_Selumetinib_30min_R1 1 FHDTSSPLLISGTSAAELPWAVKPEDK 27 1 B1AUU8;P42566 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 FHDT(0.691)S(0.154)S(0.154)PLLISGTSAAELPWAVKPEDK 70.767 0.00033445 47937000.0 2336.7 2872.3 2642.2 2821.0 3020.3 2514.6 3036.4 2660.8 926.79 1920.2 True False 2391.140563573293 2536.009780703957 2283.4037525657127 2328.3653067284017 2747.114398277275 2489.3054070741214 2807.3619033803366 2590.226940503522 1572.6949399365803 2166.6763743319075 1.1035983924044028 1.1704608084287313 1.0538739331893985 1.074625326750217 1.267893272304843 1.1489050402562755 1.2956996885360805 1.195484000836173 0.7258559508784598 1.0 11.081267966006235 -8.248601952776097 24.90843588525656 0.8629279740195192 1.1647693255431542 0.6148154859745496 0.09526168364517419 411.54747513900355 798528.8847657164 0.0653166352623964 0.024323288602233397 5.641544877443511e-09 8.248601952776097 0.301841351523635 FHDTS(ph)SPLMVTPPSAEAHWAVR ddPTM_A459_Selumetinib_30min_R1 1 FHDTSSPLMVTPPSAEAHWAVR 22 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 FHDT(0.117)S(0.442)S(0.442)PLMVTPPSAEAHWAVR 105.92 0.00011919 12199000.0 580.87 742.86 700.16 886.89 987.12 765.02 778.33 980.01 306.44 575.6 True False 594.4031408237336 655.8856058537557 605.0821177035839 732.0113104871865 897.8351702901906 757.3245933825834 719.6199414629217 954.0169512788846 520.0062985079314 649.4838668187931 0.9151930805227728 1.0098566559725628 0.9316353317093289 1.1270661949966783 1.3823825596897972 1.1660406548541382 1.1079874008074424 1.468884756062858 0.8006454433655916 1.0 9.343149879343805 -5.853866475658383 4.907184350822237 1.1821066713541935 0.958470162813548 0.19895349491519287 0.1768407169765975 0.2858321808766553 11.576317071837307 0.04774576163076793 0.07298372861432167 1.4000176934720738e-06 5.853866475658383 -0.22363650854064543 FHDTSS(ph)PLLISGTSAAELPWAVKPEDK ddPTM_A459_Selumetinib_30min_R1 2 FHDTSSPLLISGTSAAELPWAVKPEDK 27 1 B1AUU8;P42566 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 FHDT(0.044)S(0.183)S(0.774)PLLISGTSAAELPWAVKPEDK;FHDT(0.04)S(0.176)S(0.784)PLLISGTSAAELPWAVKPEDK 190.54 1.468e-32 72948000.0 5678.1 5810.2 6199.0 5945.1 6856.700000000001 6015.6 7224.5 5739.700000000001 1937.0 4595.6 True False 5810.388682340701 5129.939082911304 5357.209848669613 4906.899888348467 6236.512695648708 5955.088525727787 6679.550148521682 5587.46451082684 3286.947527117423 5185.490024934757 1.1205090848504344 0.9892872338474603 1.0331154477029425 0.946275060747071 1.202685313376372 1.1484138426826331 1.288123227776477 1.0775190934625587 0.6338740430146289 1.0 12.340264613746644 -8.146783950045892 7.828901263532181 0.8189227278292803 1.1021689582634921 0.45295556696498573 0.12496328286161293 0.23855382684884768 14.42657303929089 0.08655741183832552 0.032447543088938956 7.132077437727212e-09 8.146783950045892 0.2832462304342118 FHDTSS(ph)PLLISGTSAAELPWAVKPEDK ddPTM_A459_Selumetinib_30min_R2 1 FHDTSSPLLISGTSAAELPWAVKPEDK 27 1 B1AUU8;P42566 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 FHDT(0.044)S(0.183)S(0.772)PLLISGTSAAELPWAVKPEDK 123.84 3.2767e-12 10505000.0 167740.0 118180.0 157150.0 176800.0 184520.0 131370.0 138940.0 182930.0 128280.0 169130.0 True False 158417.68231642284 127244.02599140703 147039.14009198284 152719.53500298836 161338.94797027035 149465.02504187459 145400.98530438697 183462.29601430826 153939.58444267377 164246.777447486 0.9645101400365259 0.7747124660152939 0.89523302908634 0.9298175427022718 0.9822959724239012 0.9100027858364678 0.8852592882735582 1.1169917539049796 0.9372456911180026 1.0 17.32550553931538 -6.67279264313085 0.5483846478773811 1.0098477325820097 0.8624527859434645 0.25448673659478305 0.0725723619917979 1.2428126033404212 0.806598952782145 0.06130495799625815 0.08171222308899526 2.1242584616340141e-07 6.67279264313085 -0.14739494663854513 FHDTSS(ph)PLMVTPPSAEAHWAVR ddPTM_A459_Selumetinib_30min_R1 4 FHDTSSPLMVTPPSAEAHWAVR 22 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 FHDT(0.016)S(0.056)S(0.927)PLMVTPPSAEAHWAVR;FHDT(0.183)S(0.183)S(0.627)PLMVT(0.007)PPSAEAHWAVR;FHDT(0.005)S(0.024)S(0.971)PLMVTPPSAEAHWAVR;FHDT(0.028)S(0.15)S(0.821)PLMVTPPSAEAHWAVR 147.78 2.4128e-07 193233200.0 6093.1 6167.9 6437.799999999999 7364.6 8222.0 6395.099999999999 7979.400000000001 6476.3 2063.42 4422.42 True False 6235.057374891268 5445.759400621079 5563.5821203041205 6078.5108606635895 7478.321551712003 6330.771100286213 7377.507433748203 6304.527486012839 3501.4730337659466 4990.0806850187 1.2494902925337976 1.0913169033459569 1.1149282890369279 1.2181187528515505 1.4986374016283024 1.2686710896864966 1.4784344982430992 1.2634119333862461 0.7016866569468756 1.0 12.284847427466161 -8.247026832873164 23.931719413980606 0.8508433716456978 1.2739711851318472 0.5884626205018572 0.14117054500204448 283.7114339982853 471099.85442719056 0.10273637714714585 0.03838593844181332 5.662043050393977e-09 8.247026832873164 0.42312781348614936 FHDTSS(ph)PLMVTPPSAEAHWAVR ddPTM_A459_Selumetinib_30min_R2 5 FHDTSSPLMVTPPSAEAHWAVR 22 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 FHDT(0.008)S(0.18)S(0.811)PLMVT(0.001)PPSAEAHWAVR;FHDT(0.007)S(0.175)S(0.818)PLMVTPPSAEAHWAVR;FHDT(0.297)S(0.277)S(0.409)PLMVT(0.016)PPS(0.001)AEAHWAVR;FHDT(0.033)S(0.101)S(0.865)PLMVTPPSAEAHWAVR;FHDT(0.015)S(0.054)S(0.931)PLMVTPPSAEAHWAVR 109.28 4.333600000000001e-05 44746700.0 54143.8 50971.7 70053.2 81503.5 102240.1 56508.5 48638.100000000006 64617.7 59614.8 73001.0 True False 51134.704350804386 54881.06549015233 65546.05338015727 70402.58269862013 89395.78459990917 64292.03294191046 50899.86802456677 64805.72680896393 71539.42577668448 70893.27145062339 0.7212913624168029 0.7741364500067762 0.9245736871630983 0.9930784862658648 1.260991103537557 0.906884837254116 0.7179788290630392 0.9141308544930193 1.009114466194597 1.0 16.11336108592164 -5.2520980054753785 2.809445659442624 0.9666202155158845 0.7299937694183056 0.3321455970088363 0.1259979676409001 0.3629111407198756 5.624613521464506 0.03799206503429218 0.11882102408043878 5.5963129751787005e-06 5.2520980054753785 -0.23662644609757888 FHFPPLDTHS(ph)PTNDVQPGR ddPTM_A459_Selumetinib_30min_R2 1 FHFPPLDTHSPTNDVQPGR 19 0 P41162 P41162 ETV3 ETS translocation variant 3 1 FHFPPLDTHS(0.931)PT(0.069)NDVQPGR 108.99 0.00037316 2084200.0 24927.0 16667.0 21978.0 25058.0 19459.0 15998.0 19195.0 28699.0 23016.0 27294.0 True False 23541.6571306872 17945.305307148254 20563.9594078371 21645.057172538945 17014.386454332813 18201.579284615294 20087.605534170914 28782.509338624797 27619.843120771555 26505.951301671463 0.8881649582296888 0.6770292868536518 0.7758242356138465 0.8166112178427646 0.6419081609517591 0.6866978316476234 0.7578526537511668 1.085888561819314 1.0420242158609057 1.0 14.694028699581944 -7.755322257853552 24.632949147909876 1.0479673217587464 0.7434744007805186 0.7856428516619076 0.07018977174803648 49.500026660530075 199333.72428248398 0.033929338464793284 0.018938257381214206 1.7566196725422673e-08 7.755322257853552 -0.3044929209782278 FHHTIGGSR ddPTM_A459_Selumetinib_30min_R1 1 FHHTIGGSR 9 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 119.21 0.0097916 4480100.0 2208.6 2019.2 2244.9 2316.0 3492.0 2737.4 2422.9 2293.1 1655.3 1255.3 False True 2260.0560828125035 1782.7911252993863 1940.0549103530257 1911.5540767043517 3176.1492165626755 2709.8642413603366 2240.138702312018 2232.279538961449 2808.923201671387 1416.4299826574536 1.5956002841540178 1.2586510785055394 1.3696793587446987 1.3495577614912984 2.242362316140542 1.9131649813541713 1.5815386074426019 1.5759900357187642 1.9831006375630293 1.0 10.468043572456818 FHINWEDNTEKLEDAES(ph)SNPNLQSLLSTDALPSASK ddPTM_A459_Selumetinib_30min_R1 1 FHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASK 36 1 Q9Y294 Q9Y294 ASF1A Histone chaperone ASF1A 1 FHINWEDNT(0.032)EKLEDAES(0.446)S(0.446)NPNLQS(0.032)LLS(0.035)T(0.009)DALPSASK 50.70399999999999 0.0031852 14889000.0 1045.6 1334.4 1499.0 1622.2 1149.8 1098.4 1187.9 1162.5 851.03 838.03 True False 1069.9604456165682 1178.16782765427 1295.4440334176074 1338.9132224653717 1045.800793013677 1087.3510932674048 1098.295746616223 1131.6667236678231 1444.135753228054 945.5993136034617 1.1315156750052988 1.2459482686853305 1.3699714189522494 1.4159414068978975 1.1059661084443584 1.1499068131973993 1.1614811165956436 1.1967719385870759 1.5272174296793686 1.0 9.885085178059585 -6.273424481913355 24.93303659776427 1.1966095116378135 1.2932892925582922 0.10315377152240701 0.14454199194773334 1929.865016128725 4014762.3370936844 0.04565535138758291 0.05213939945455386 5.328138655772178e-07 6.273424481913355 0.09667978092047869 FHPEPYGLEDDQR ddPTM_A459_Selumetinib_30min_R2 2 FHPEPYGLEDDQR 13 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 0 ; 128.21 0.0025977 9400500.0 70993.0 60007.0 69171.0 66257.0 76857.0 55954.0 56814.0 66413.0 49432.0 59697.0 False True 67047.49326749603 64609.34394708382 64720.61316769049 57232.6823002998 67201.53654970224 63661.15560016024 59455.96357480524 66606.25083473597 59319.78124548048 57973.392498566755 1.1565218176451137 1.1144654670447502 1.1163847823687487 0.9872232731888984 1.1591789552657907 1.0981098889759486 1.0255733020329134 1.1489106978927037 1.0232242532114542 1.0 15.823103291548827 FHPIQGHR ddPTM_A459_Selumetinib_30min_R1 1 FHPIQGHR 8 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 142.64 0.0030943000000000003 4387000.0 1586.5 1930.8 1843.8 2262.7 1960.7 1544.5 1971.0 1634.3 1132.7 1624.7 False True 1623.4623632083824 1704.7410383954325 1593.4220872684355 1867.5619211394378 1783.3550311897 1528.9637322937965 1822.3258831387961 1590.95305504544 1922.109170865208 1833.2460709181594 0.885567076325597 0.9299030094424985 0.8691806913135175 1.0187186274475917 0.972785410251297 0.8340199150286646 0.9940432504110623 0.8678338823596279 1.0484730889959266 1.0 10.840184732005593 -13.31763931456827 0.012368683096549917 1.9781110804944044 0.07323590012616063 0.16335672363084497 0.06470136346422534 13878.948968838684 15.88822044807463 1423.9866676204394 1048.5631697506115 4.8123885568149087e-14 13.31763931456827 -1.9048751803682438 FHQLDIDDLQSIR ddPTM_A459_Selumetinib_30min_R2 1 FHQLDIDDLQSIR 13 0 P16152;E9PQ63;A8MTM1;P16152-2;O75828 P16152 CBR1;CBR3 Carbonyl reductase [NADPH] 1;Carbonyl reductase [NADPH] 3 0 98.592 0.017465 1488400.0 9799.7 9259.4 10181.0 11597.0 13406.0 7551.7 6683.3 9084.5 9216.4 11167.0 False True 9255.071905307308 9969.56620633639 9525.965544234661 10017.468594059146 11721.818428839393 8591.878127492764 6994.086692707712 9110.93439098006 11059.937527731967 10844.57969464956 0.8534283638372381 0.9193132871027839 0.8784079985077274 0.9237304603885673 1.0808919071914462 0.7922739626074932 0.6449384752235642 0.8401371604540067 1.0198585689022748 1.0 13.404686518848688 FHRASVLFANEKYK ddPTM_A459_Selumetinib_30min_R1 1 FHRASVLFANEKYK 14 2 G5EA36;P30260;P30260-2;I3L394 G5EA36 CDC27 Cell division cycle protein 27 homolog 0 79.46600000000002 0.02282 11143000.0 3851.4 3440.2 4801.8 4378.3 4167.8 3321.5 4086.0 3728.0 2445.1 3155.6 False True 3941.130126480154 3037.4197846944107 4149.741934399377 3613.7120958698915 3790.823225884855 3288.088725680705 3777.7897303425293 3629.12132974937 4149.1561169617 3560.651998146948 1.1068563084882255 0.8530515720927403 1.1654444007892393 1.0149017926353257 1.0646430001746012 0.9234513025681557 1.0609825763114693 1.0192294365296175 1.1652798754612987 1.0 11.797925724833332 FHS(ph)LPFSLTK ddPTM_A459_Selumetinib_30min_R1 1 FHSLPFSLTK 10 0 J3KRR7;Q9NQC7-2;Q9NQC7 J3KRR7 CYLD Ubiquitin carboxyl-terminal hydrolase CYLD 1 FHS(1)LPFSLTK 81.565 0.029624 7344200.0 4661.0 5872.7 5813.6 5916.6 5381.1 5028.1 4918.5 4686.2 2698.1 4337.0 True False 4769.592231272786 5185.121553855836 5024.145051818947 4883.376878337212 4894.380455110367 4977.521879149526 4547.493585092934 4561.906753077118 4578.478638572805 4893.696195957442 0.9746400349112038 1.0595511748643354 1.026656508830537 0.9978913039945645 1.0001398246081337 1.0171293189923254 0.9292553936734984 0.9322006455663499 0.9355870195528218 1.0 12.256708825353972 -7.255717745400951 24.77880693877036 0.9436108174482652 1.0141937896932312 0.5483965469152643 0.027981075238268416 283.74134994988054 1228808.0410949385 0.010663295910310185 0.008035114388673064 5.5498628981643536e-08 7.255717745400951 0.0705829722449659 FHS(ph)PSTTWSPNK ddPTM_A459_Selumetinib_30min_R1 1 FHSPSTTWSPNK 12 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 FHS(0.828)PS(0.163)T(0.007)T(0.002)WSPNK 115.37 0.0052724 25453000.0 2671.4 4369.1 2730.4 2954.9 3307.2 3112.5 3772.3 3291.9 1375.9 2992.5 True False 2733.638422360462 3857.563740860514 2359.626677013632 2438.8821853426994 3008.064343933585 3081.191075923886 3487.7523739038465 3204.588118401812 2334.8018082399935 3376.6165244184117 0.8095791756605537 1.1424346569899406 0.6988139339927131 0.7222858052448737 0.8908516327455022 0.912508439629398 1.0329133760620262 0.9490530225234179 0.6914619387056811 1.0 11.721362629321733 -6.515220738856923 23.224512502742307 0.9190631965644104 0.8483579351599554 0.057259493893560665 0.1408899632125662 517.5039578238817 1569451.6302817564 0.04714170269844137 0.04925194769969841 3.0533687829918946e-07 6.515220738856923 -0.07070526140445499 FHS(ph)PSTTWSPNK ddPTM_A459_Selumetinib_30min_R2 3 FHSPSTTWSPNK 12 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 FHS(0.599)PS(0.332)T(0.068)T(0.001)WSPNK;FHS(0.794)PS(0.118)T(0.042)T(0.042)WS(0.005)PNK;FHS(0.819)PS(0.179)T(0.002)TWSPNK 82.515 0.023938 107067000.0 666704.0 454705.0 652254.0 640859.0 741342.0 551363.0 620357.0 633335.0 546868.0 536787.0 True False 629651.2607075733 489579.4113929839 610288.6877604604 553572.8986565619 648207.9902784311 627308.2484750174 649204.8297140747 635177.8999957469 656256.8807685986 521288.5645698804 1.207874684968591 0.9391715926033023 1.1707310101153183 1.0619317903382737 1.2434724916961741 1.2033800300081678 1.245384752013003 1.2184765658917487 1.2589128658712891 1.0 18.99172268653019 -6.259291437643222 24.992753779363067 1.2088060745155969 1.0892164138996074 0.19675558902591317 0.09630976370843775 249.87000008218607 2907408.189952708 0.026864048401795078 0.032976468767052056 5.504381954001575e-07 6.259291437643222 -0.11958966061598941 FHS(ph)PSTTWSPNKDTPQEK ddPTM_A459_Selumetinib_30min_R2 1 FHSPSTTWSPNKDTPQEK 18 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 FHS(0.942)PS(0.045)T(0.01)T(0.002)WSPNKDTPQEK 62.362 0.01805 17546000.0 218760.0 197100.0 200390.0 247740.0 216930.0 152250.0 119210.0 143760.0 91351.0 231880.0 True False 206602.19496566505 212216.9362236104 187497.12556813503 213997.38462466275 189677.31402119427 173221.05551210616 124753.50121013363 144178.31779925092 109623.75256020144 225185.02190340674 0.9174775179065293 0.9424114198618458 0.8326358653132891 0.9503180221127543 0.8423176302665302 0.7692387977136839 0.5540044366878305 0.6402660202733035 0.4868163594256487 1.0 17.78075134473101 -6.8817334130302115 2.4329721312266974 0.641188822075645 0.9042553977995123 0.3914109939176492 0.1315091224366548 0.2548328425885149 3.0706765191602647 0.04912356727857034 0.042160215697754314 1.3130056260007492e-07 6.8817334130302115 0.26306657572386727 FHSPS(ph)TTWSPNKDTPQEK ddPTM_A459_Selumetinib_30min_R1 1 FHSPSTTWSPNKDTPQEK 18 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 FHS(0.011)PS(0.443)T(0.443)T(0.102)WSPNKDTPQEK 106.6 0.00090712 35495000.0 3656.3 3119.0 4651.6 5417.5 4956.8 3803.3 3845.8 3672.5 2065.4 3243.1 True False 3741.4846760786727 2753.826030016238 4019.9382694098367 4471.435324069874 4508.4583151941215 3765.0422551201036 3555.7082097286566 3575.093370038778 3504.8329491524655 3659.3834754691234 1.0224358013200636 0.7525382481712182 1.0985288358975527 1.2219094702821893 1.2320267458758607 1.028873382732165 0.9716686522646616 0.9769660364934726 0.9577659659468062 1.0 11.837384891694382 -10.550319196671913 13.737506906555014 1.0000161854234726 1.031489729078877 0.0041921792882057 0.1307127959161387 0.0 0.0 0.1403447779578517 0.03403860844259293 2.8163122442752625e-11 10.550319196671913 0.031473543655404335 FHSPS(ph)TTWSPNKDTPQEK ddPTM_A459_Selumetinib_30min_R2 1 FHSPSTTWSPNKDTPQEK 18 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 FHS(0.005)PS(0.332)T(0.332)T(0.332)WS(0.001)PNKDTPQEK 67.29899999999999 0.016368 7701500.0 19004.0 17719.0 19083.0 22878.0 26072.0 12994.0 9737.8 14560.0 10526.0 23550.0 True False 17947.833759039575 19077.990324435104 17855.220555999433 19761.976933248694 22796.602273362718 14783.80555221221 10190.62699508464 14602.367189462237 12631.494121013271 22870.05030975169 0.7847745639364291 0.8341910081544653 0.7807250230834012 0.8640985334790573 0.9967884619668872 0.6464264552102215 0.4455883068494782 0.6384930068665329 0.5523159743827611 1.0 14.48117191895664 -6.887684333787627 8.03264118511633 0.6174823303302003 0.8473142347107806 0.2949337432035348 0.14552999303585265 0.25595490973735796 17.088089927680635 0.04896417418307895 0.04319487988596452 1.2951368674667455e-07 6.887684333787627 0.22983190438058032 FHSQLMR ddPTM_A459_Selumetinib_30min_R2 1 FHSQLMR 7 0 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 0 88.029 0.046105 3050200.0 3112.1 1020.1 2728.9 3259.3 3326.2 1379.6 1402.4 3338.0 2096.5 2585.4 False True 2939.1419407233775 1098.3383898615193 2553.3255450016695 2815.377717393892 2908.3330193947163 1569.6273772381069 1467.6143788028808 3347.713027364352 2515.8585811043426 2510.752784324077 1.1706217987983345 0.4374538173248325 1.0169561738389363 1.1213281271544318 1.1583510083322173 0.6251620577852584 0.5845316145683292 1.3333503195797887 1.0020335720872815 1.0 11.293904268513309 -7.772996531079407 24.999864033601238 1.1257688374446684 0.8731717023718522 0.15221944039828528 0.2570894654409276 435.69491449100474 942459.2211878588 0.14254240752230551 0.06939354503759862 1.6865664967592744e-08 7.772996531079407 -0.2525971350728162 FHVEEEGK ddPTM_A459_Selumetinib_30min_R1 5 FHVEEEGK 8 0 P00558-2;P00558;P07205 P00558-2 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 ;;;; 137.9 0.003515 72001400.0 43332.299999999996 53235.4 39378.299999999996 42826.899999999994 40183.700000000004 41428.3 45327.3 40834.5 25324.899999999998 42336.9 False True 44341.85828002181 47002.57461953399 34030.94314951873 35347.98587547912 36549.09143000845 41011.56891588676 41908.225267781396 39751.43641085049 42974.505642486365 47771.25351132829 0.9282121573281881 0.9839091747589999 0.7123728319469107 0.7399426072647819 0.7650854592153697 0.8584989067988646 0.8772686958663005 0.8321204383180775 0.8995892400498882 1.0 15.54385511298099 -8.747775875987937 0.9815075556497614 1.00037555684689 0.8298101413862061 0.286880895292859 0.07897738985177008 1.2625958672608237 2.3910428060991658 0.08415047266082325 0.02758278829041868 1.78740975579614e-09 8.747775875987937 -0.17056541546068382 FHVEEEGK ddPTM_A459_Selumetinib_30min_R2 3 FHVEEEGK 8 0 P00558-2;P00558;P07205 P00558-2 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 ;; 143.28 0.0030366 74150000.0 743590.0 603600.0 678360.0 679730.0 658660.0 542860.0 640510.0 650330.0 501990.0 583250.0 False True 702264.2446266166 649894.1791200981 634715.056142522 587149.6014003468 575913.2423048896 617634.0374075671 670294.9841464875 652222.3526320728 602402.02677251 566410.0570345089 1.239851298374511 1.1473916662473789 1.1205928430466614 1.036615777047501 1.0167779246719868 1.0904362126641007 1.1834093971704485 1.1515020690960924 1.0635440160198433 1.0 19.11148735621542 -1.5229445033260676 0.01270074347400717 5.382847178568141e-08 2.400951279395563 0.2933293319463067 0.06174579430107942 13589.826317887238 13.385083090792415 1047.3919266601313 1524.2268787465223 0.029995457938998073 1.5229445033260676 2.4009512255670913 FICVTPTTCSNTIDLPMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 FICVTPTTCSNTIDLPMSPR 20 0 G8JLH9;P40763;P40763-2 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 1 FICVTPTTCSNTIDLPMS(1)PR;FICVTPTTCSNTIDLPMS(1)PR 222.21 6.7249e-20 52278000.0 4291.4 5509.3 5460.0 6361.1 5473.8 5268.3 6006.200000000001 6089.200000000001 3138.5 3615.4 True False 4391.381270389194 4864.268594795918 4718.561989633178 5250.253297635604 4978.695756477885 5215.305685233678 5553.147498380638 5927.694635490845 5325.805273029447 4079.4718069782202 1.0764582961150584 1.1923770588327753 1.156660031713358 1.2869934016101499 1.2204265630568838 1.2784267012980786 1.3612417884299612 1.453054443310801 1.3055134402251012 1.0 11.994166654804273 -5.464448071640963 0.805907292711735 1.3075141104690884 1.0750456080203943 0.19285780127677987 0.11418561303376638 1.5743651577675735 1.477395778207528 0.04795521634291695 0.276793332534112 3.432036740230329e-06 5.464448071640963 -0.2324685024486941 FICVTPTTCSNTIDLPMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 FICVTPTTCSNTIDLPMSPR 20 0 G8JLH9;P40763;P40763-2 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 1 FICVTPTTCS(0.001)NT(0.011)IDLPMS(0.988)PR;FICVTPTTCSNT(0.001)IDLPMS(0.999)PR 108.49 0.00027956 11624500.0 51276.0 49122.0 59931.0 66981.0 65381.0 43057.0 42066.0 42638.0 40636.0 64636.0 True False 48426.28519409141 52889.49944787526 56075.10470793911 57858.07225133014 57167.254266444 48987.71091746969 44022.15235219765 42762.069520899095 48764.33546470599 62769.79073550362 0.7714903081029504 0.842594802820652 0.893345414265052 0.9217502810409189 0.9107447005412631 0.7804345106691815 0.7013270529719641 0.6812523830306825 0.7768758648596877 1.0 15.93778277876271 -6.870275753554741 6.059354233023834 0.7605014893982192 0.8706134798137981 0.13109136291933 0.09102375581290903 0.3045296381420555 15.183975158026467 0.03168120469199512 0.027968572266603264 1.348106635836176e-07 6.870275753554741 0.11011199041557895 FIEEHATK ddPTM_A459_Selumetinib_30min_R2 2 FIEEHATK 8 0 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 ; 132.76 0.0045428000000000005 8733200.0 119155.0 102121.0 135708.0 155058.0 163042.0 113022.0 111002.0 128074.0 107025.0 133747.0 False True 112532.84211525785 109953.35232923052 126976.69502769859 133938.83291003018 142559.2063460265 128589.75458843545 116163.81294629017 128446.67413620786 128432.99052835297 129885.37659356104 0.8664011689891545 0.8465414291656399 0.9776057810190262 1.031207949830667 1.0975770335726445 0.9900248816371386 0.8943563624548084 0.9889232914814176 0.9888179400691666 1.0 16.98687948564188 -5.311204612527347 4.717567600854665 0.997827130871516 0.8556053092203035 0.5840539108136027 0.04728579138335692 0.14759621233289305 7.344735937878533 0.014079770691480285 0.03193650159801985 4.884221909918839e-06 5.311204612527347 -0.14222182165121244 FIHQQPQS(ph)SSPVYGSSAK ddPTM_A459_Selumetinib_30min_R1 1 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQS(0.621)S(0.189)S(0.189)PVYGSSAK 154.47 4.3835e-05 51567000.0 3758.4 4368.3 4376.5 4780.5 4523.5 3687.6 4470.5 3544.1 1659.8 2619.2 True False 3845.9634074266564 3856.8574052324257 3782.195338393704 3945.675416098945 4114.350223688788 3650.5060920729084 4133.286585779799 3450.098955140757 2816.559373004389 2955.3998331684884 1.3013343792820729 1.3050205126043752 1.2797575799883587 1.3350733027107133 1.3921467334177207 1.2351987203569663 1.398554110815015 1.1673882215259859 0.9530214292476127 1.0 11.52913760907766 -8.048154656962279 3.463144234446189 0.9818119479545233 1.318408982629471 0.8882049596466799 0.04868823455019195 0.07098113670121191 1.6648261648821958 0.0348093936051665 0.01241286263839498 8.950459732384963e-09 8.048154656962279 0.3365970346749476 FIHQQPQSS(ph)SPVYGSSAK ddPTM_A459_Selumetinib_30min_R1 1 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQS(0.087)S(0.456)S(0.456)PVYGSSAK 73.672 0.011514 176050000.0 4692.3 5760.4 6027.3 5858.8 5753.1 5056.9 5142.4 5062.2 2734.3 3836.3 True False 4801.621460373586 5085.969690062696 5208.825765589024 4835.67056329683 5232.733120792301 5006.0321772978305 4754.504627830005 4927.934011656991 4639.907394629414 4328.726473726435 1.1092457538071363 1.1749344110634876 1.2033159861692404 1.1171116014484477 1.208838939709591 1.1564676603343635 1.0983610668606265 1.1384258260639697 1.0718874067908235 1.0 12.079726926176606 -8.479218151192683 0.7420359150543983 0.9994489215000091 1.1639881486934585 0.6837994653882363 0.03383754399181971 0.39966170612380414 0.50100745029276 0.03248767067507337 0.012565436138339166 3.3172778495293223e-09 8.479218151192683 0.16453922719344938 FIHQQPQSS(ph)SPVYGSSAK ddPTM_A459_Selumetinib_30min_R2 1 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQSS(0.632)S(0.368)PVYGSSAK 140.63 0.00020937 20857000.0 122910.0 123000.0 149190.0 172040.0 175070.0 126580.0 127760.0 120230.0 116410.0 159580.0 True False 116079.15424771368 132433.70449266428 139591.27782579002 148607.85521444675 153076.14145434235 144015.24602116543 133701.09315163738 120579.84939485196 139695.25276716278 154972.5107613662 0.749030609863821 0.8545625533330347 0.9007486369033479 0.9589304224623422 0.9877631891120099 0.929295429967749 0.8627407047532222 0.77807250332626 0.9014195619652311 1.0 17.241652805385392 -4.810710585640445 2.1223671133414945 0.9097093802447047 0.7114723123030553 0.41272103288918816 0.06060747950669253 0.730180491281573 3.956037068000084 0.017934030512461216 0.27502754512031574 1.546284542128465e-05 4.810710585640445 -0.19823706794164941 FIHQQPQSSS(ph)PVYGSSAK ddPTM_A459_Selumetinib_30min_R1 1 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQSS(0.036)S(0.964)PVYGSSAK 132.65 0.00031344 144870000.0 7377.5 7906.0 8872.6 8629.0 8793.1 6297.9 7554.6 6610.8 2954.4 5431.6 True False 7549.381395883928 6980.361844600318 7667.749653703177 7122.107136391133 7997.7656575478995 6234.548844035679 6984.750439756643 6435.4601090952665 5013.401019161448 6128.798768264343 1.2317881009530827 1.1389445319604017 1.2511015524620757 1.162072276425563 1.3049483202093846 1.0172546170579009 1.1396605931858164 1.0500361249285672 0.8180071183151649 1.0 12.58138862107567 -7.630852301962951 1.1024175976024828 0.9200210562625839 1.203233843653631 0.6216278219997766 0.08405200436787737 0.3287809731793788 0.7313750381065507 0.0666668603499353 0.02860806364177666 2.3396327827667433e-08 7.630852301962951 0.28321278739104705 FIHQQPQSSS(ph)PVYGSSAK ddPTM_A459_Selumetinib_30min_R2 3 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQS(0.001)S(0.049)S(0.95)PVYGSSAK;FIHQQPQSS(0.142)S(0.858)PVYGSSAK;FIHQQPQSS(0.181)S(0.819)PVYGSSAK 178.03 1.2516e-09 551602000.0 1151580.0 1157030.0 1346160.0 1449900.0 1504700.0 1123190.0 1164280.0 1140420.0 1070870.0 1343810.0 True False 1087579.7937399903 1245770.480562171 1259549.5311881874 1252421.1187829934 1315666.1338113262 1277899.2271963411 1218421.326977053 1143738.4333933068 1285073.9226077797 1305010.713662313 0.8333876360967672 0.9546055580387586 0.9651641308395501 0.9597017906989169 1.0081650058788485 0.9792250851413413 0.933648524277429 0.8764207231552756 0.9847228908959806 1.0 20.31563022016841 -4.761483116863036 5.772457444425276 0.9599460144134425 0.8280800399908997 0.5425316530055663 0.03551104876464322 0.11914123035817308 13.991489024991028 0.0093592111241892 0.0624906996017891 1.731876355891479e-05 4.761483116863036 -0.13186597442254278 FIHQQPQSSSPVY(ph)GSSAK ddPTM_A459_Selumetinib_30min_R1 2 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQSSSPVY(0.98)GS(0.016)S(0.004)AK;FIHQQPQS(0.005)S(0.018)S(0.098)PVY(0.536)GS(0.311)S(0.031)AK 138.31 0.004321800000000001 32426900.0 6001.1 6140.6 6790.6 6755.9 6429.200000000001 6955.5 5719.8 4751.7 2799.88 3970.76 True False 6140.913953892106 5421.655697312505 5868.473818095803 5576.108888949452 5847.679995167454 6885.533985088702 5288.3508809626 4625.669480303132 4751.191864855721 4480.445724477744 1.3706033576844439 1.2100706114333015 1.3097968771354445 1.2445433405176272 1.305155860547575 1.5367966511615991 1.1803180322152051 1.0324127921094985 1.0604283941882895 1.0 12.129426546522389 -7.549652324107671 4.833933804859966 1.0418022488922085 1.3215614027598261 0.7174684993959188 0.0839479929684655 0.11118758765140563 6.622519992486939 0.04171517210458405 0.024186551862854625 2.8206401004680777e-08 7.549652324107671 0.2797591538676176 FIHQQPQSSSPVY(ph)GSSAK ddPTM_A459_Selumetinib_30min_R2 3 FIHQQPQSSSPVYGSSAK 18 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 FIHQQPQSSSPVY(0.962)GS(0.029)S(0.008)AK;FIHQQPQSSS(0.003)PVY(0.972)GS(0.019)S(0.006)AK;FIHQQPQSS(0.001)S(0.002)PVY(0.884)GS(0.088)S(0.025)AK 118.23 0.0065381 51817000.0 95860.0 99540.0 104314.0 127968.0 137817.0 152376.0 115915.0 126234.0 107118.0 179305.0 True False 90532.48495798418 107174.39792845368 97602.55080849583 110538.53764288727 120503.19636038774 173364.4108683922 121305.27718121516 126601.3200408363 128544.59312699051 174127.99875966186 0.5199191721197037 0.6154920443114946 0.5605218661199375 0.6348119683811263 0.6920380250088951 0.9956147897138381 0.6966442964100527 0.7270589505572639 0.7382189770894495 1.0 17.409788672968666 -6.368246369493243 2.9107985830928707 0.8077564917852815 0.5794284649843866 0.5538968712792778 0.10340275494774451 0.22505044169152716 3.680652117519276 0.033960118895623996 0.039614492912187695 4.283054794553342e-07 6.368246369493243 -0.22832802680089492 FIIPNVVK ddPTM_A459_Selumetinib_30min_R2 1 FIIPNVVK 8 0 P00338;P00338-3;P00338-5;P00338-2;F5GYU2;F5GXY2 P00338 LDHA L-lactate dehydrogenase A chain 0 134.44 0.038884 3958100.0 97374.0 75225.0 101030.0 92319.0 98780.0 65035.0 62302.0 76440.0 65417.0 81367.0 False True 91962.34289900638 80994.51561350137 94529.83979314708 79744.99294084196 86370.37329559558 73992.98092104985 65199.16644907092 76662.42774467672 78502.22790369802 79017.72329314503 1.1638191922821994 1.0250170751316474 1.1963118633835375 1.0092038800586403 1.09305064352681 0.9364099323204483 0.8251207922960633 0.9701928194041927 0.9934762054895635 1.0 16.269888658654104 -6.761275368299606 9.354001749426 0.9355672404672744 1.0941454870081144 0.5444515513213868 0.06941802325201483 0.07706262769888442 95.02761636087749 0.023379134608301343 0.021964954948790194 1.7327050122737128e-07 6.761275368299606 0.15857824654084007 FIPHENGVHTIDVK ddPTM_A459_Selumetinib_30min_R1 1 FIPHENGVHTIDVK 14 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7 O75369-8 FLNB Filamin-B 0 125.84 0.00075952 8209500.0 4005.2 4359.4 5381.0 4901.5 5201.5 4268.2 4361.6 4257.2 2366.4 3177.5 False True 4098.51336723745 3848.9994213699206 4650.28975571724 4045.545037550253 4731.025243399409 4225.265783215531 4032.6010004556933 4144.28522666551 4015.6079649822814 3585.363076471009 1.1431236613479947 1.073531282404571 1.2970205963894774 1.1283501701959262 1.3195386750220146 1.1784764033924182 1.1247399257608492 1.1558899721655624 1.1200003679780046 1.0 11.80790350738319 -8.714166428736744 0.8372342828896239 1.0005750172296997 1.1875815711849365 0.3768561716704033 0.07123826576857237 0.9501135905910749 1.3737619563195185 0.06980633993005973 0.024420236537171642 1.931228097053383e-09 8.714166428736744 0.1870065539552368 FIQELSGS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 FIQELSGSSPK 11 0 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 FIQELSGS(0.915)S(0.085)PK;FIQELS(0.009)GS(0.69)S(0.301)PK 140.45 0.0010849 252510000.0 11494.8 13016.8 16658.4 16751.0 11374.1 13218.8 11096.9 11481.5 9242.8 12511.5 True False 11762.606475012748 11492.78700465385 14396.280778041277 13825.752305213568 10345.31466326045 13085.830873710102 10259.851898834553 11176.973322831916 15684.356532597285 14117.472897330304 0.8331949039715971 0.8140824557082877 1.0197491351843642 0.9793362031407262 0.7328021621501968 0.9269244551682269 0.726748474989086 0.791712043941345 1.1109889600399578 1.0 13.785194241190968 -8.262931221319176 24.998535419163236 1.0554944936477932 0.8557764116450787 0.4172125292315302 0.09565502437246677 137.87624772246187 2310248.2663809243 0.08079181992893082 0.02516296732272694 5.45844298934166e-09 8.262931221319176 -0.19971808200271457 FIQELSGS(ph)SPKR ddPTM_A459_Selumetinib_30min_R1 1 FIQELSGSSPKR 12 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 FIQELS(0.002)GS(0.499)S(0.499)PKR 75.968 0.024975 25208000.0 1087.0 1692.8 1584.9 1574.2 1348.5 1445.5 1608.2 1512.4 662.73 1255.8 True False 1112.3249850661907 1494.6061890386297 1369.6792852325325 1299.2955213937787 1226.5284130970122 1430.9595824089897 1486.8921792307513 1472.2862390324428 1124.6044061159168 1416.9941625278664 0.784989108975469 1.0547722979834344 0.9666089822057377 0.916937808040001 0.8655846619078019 1.0098556650764245 1.0493283730810785 1.0390206805128521 0.7936549322896739 1.0 10.468618099580372 -6.789120898209261 24.98686903809888 0.9852455007712282 0.9280553595506006 0.08859224982258873 0.09304106993962805 605.8710725770711 546888.5456775072 0.032759000798845396 0.028896889528879383 1.6250963010450383e-07 6.789120898209261 -0.0571901412206276 FIQELSGSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 FIQELSGSSPK 11 0 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 FIQELS(0.001)GS(0.11)S(0.89)PK;FIQELSGS(0.234)S(0.766)PK;FIQELS(0.008)GS(0.294)S(0.698)PK 133.04 0.0018966 112334000.0 240311.0 238742.0 219455.0 199706.0 190911.0 154390.0 194467.0 181276.0 139796.0 174173.0 True False 226955.47666115343 257052.74372347674 205335.50422453746 172505.69828793433 166927.05341400535 175655.82108712054 203510.10082904992 181803.4831481429 167759.1062265983 169144.1729341991 1.3417871436188595 1.5197256829147525 1.2139673549642034 1.019873728402355 0.9868921318320776 1.0384976203434133 1.2031753580315174 1.0748433126269656 0.9918113247203637 1.0 17.367893951162337 -5.497079354449889 3.700215453027026 1.05339152199199 1.4273691421241776 0.8176902872202936 0.07250365750257427 0.09085148625011574 2.641899475684461 0.020624050241001626 0.04324584017218829 3.183615757117788e-06 5.497079354449889 0.3739776201321876 FIQELSGSS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 FIQELSGSSPKR 12 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 FIQELSGS(0.008)S(0.992)PKR 98.421 0.0078542 16883000.0 46345.0 51391.0 51475.0 52140.0 50244.0 32243.0 44277.0 37799.0 35778.0 55123.0 True False 43769.33043373443 55332.524451890335 48163.15454174243 45038.44205348312 43931.89953294095 36684.1805771878 46335.96823321104 37908.988832038696 42934.599720844846 53531.455763245955 0.8176375891459675 1.0336450534170036 0.8997168833732831 0.8413453624850974 0.8206744783336167 0.6852827006878208 0.865583937005964 0.7081628603507276 0.8020443141081774 1.0 15.70809926616197 -5.859528369751856 2.379849998393452 0.796346459616174 0.9326875324019415 0.1778617161053314 0.09527213697017356 0.3756307482902416 4.328499898551372 0.02718746330696973 0.04647154451179231 1.3818841330747284e-06 5.859528369751856 0.13634107278576746 FIQENVFVAANHNGS(ph)PLSIK ddPTM_A459_Selumetinib_30min_R1 2 FIQENVFVAANHNGSPLSIK 20 0 E9PFD2;P11172-4;P11172-2;P11172-3;P11172 E9PFD2 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 1 FIQENVFVAANHNGS(0.993)PLS(0.007)IK;FIQENVFVAANHNGS(0.958)PLS(0.042)IK 127.94 0.00012969999999999998 123538000.0 5984.4 6252.8 6396.4 7063.0 5866.5 5191.7 6324.7 5355.6 3346.2 4127.0 True False 6123.824876384649 5520.719269152143 5527.804012910198 5829.579638930417 5335.8761108147 5139.476211686437 5847.622786954815 5213.5520905594785 5678.257003221647 4656.740650384221 1.3150452937247816 1.1855329045856646 1.1870542999756937 1.2518583439791577 1.1458392277814407 1.103663827888372 1.2557329741935135 1.1195710652534012 1.2193629470761147 1.0 12.185104820497903 -14.52287874528033 0.13476578893947813 0.3692134215277679 1.2662283488277941 0.5219404845840218 0.059391713773070634 117.48840391465365 0.9816946634873195 20.12364239485418 0.39926984905144397 3.0000000000000503e-15 14.52287874528033 0.8970149273000262 FIQENVFVAANHNGS(ph)PLSIK ddPTM_A459_Selumetinib_30min_R2 2 FIQENVFVAANHNGSPLSIK 20 0 E9PFD2;P11172-4;P11172-2;P11172-3;P11172 E9PFD2 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 1 FIQENVFVAANHNGS(0.991)PLS(0.009)IK;FIQENVFVAANHNGS(0.922)PLS(0.078)IK 77.554 0.0034663000000000003 20958700.0 86995.0 79430.0 83839.0 98638.0 88295.0 65218.0 76342.0 85844.0 62839.0 85459.0 True False 82160.1661685775 85522.02559229515 78444.89001700126 85203.33423995925 77202.59273268486 74201.1875099413 79892.05426880321 86093.79182776074 75408.55586835969 82991.5766208523 0.98998198990636 1.0304904313723695 0.9452150833978897 1.0266503868122832 0.9302461270905305 0.8940809481054931 0.9626525669441216 1.037379880383294 0.9086290312674056 1.0 16.34067729451484 -6.266124926541598 24.971866874115133 0.9546539534370126 0.996622799021323 0.17769901497792873 0.04481347191814841 755.6470983636468 4027252.328279822 0.014014412224958866 0.016399041709743205 5.418450041033473e-07 6.266124926541598 0.041968845584310355 FIQESEEK ddPTM_A459_Selumetinib_30min_R1 1 FIQESEEK 8 0 Q13129 Q13129 RLF Zinc finger protein Rlf 0 132.57 0.042763 0.0 1147.1 1325.7 1607.7 1545.3 860.43 1209.8 1189.7 1330.5 1000.6 1348.3 False True 1173.8251981319486 1170.48642769879 1389.383170463967 1275.44236387359 782.6042584212543 1197.6305104105118 1099.9599711670344 1295.2108179269144 1697.9451190674724 1521.3674385541658 0.7715593014449523 0.769364716265496 0.9132462909712131 0.8383526106524989 0.5144084450532237 0.7872066143000155 0.7230074361341552 0.8513464828442893 1.1160651109248911 1.0 10.57115291751414 -8.096755123149087 3.9671255007775557 1.0540648951515543 0.7614551410276998 0.580246843322759 0.09997863083753297 0.17624899637237051 4.804165899602186 0.07838785044571231 0.027420077725833145 8.002853685491596e-09 8.096755123149087 -0.2926097541238545 FIVS(ph)PVPESR ddPTM_A459_Selumetinib_30min_R1 3 FIVSPVPESR 10 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4;H0YH68 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 FIVS(0.942)PVPES(0.058)R;FIVS(0.94)PVPES(0.06)R;FIVS(0.999)PVPES(0.001)R 113.38 0.007664 29575200.0 4058.76 5267.9 5332.1 5998.5 4519.68 4512.1 5201.2 4696.5 2324.4 3984.0 True False 4153.321211027835 4651.1318190197335 4608.0301071287695 4950.974580790611 4110.875742014314 4466.712370659011 4808.8692964898555 4571.933563618006 3944.337032540909 4495.3852074462675 0.9239077452468746 1.034645887813014 1.0250578970398163 1.1013460142614018 0.9144657359295834 0.9936217175027043 1.0697346444358817 1.0170282084046862 0.8774191421921778 1.0 12.13422902955895 -8.224706774902883 24.100745989808832 0.9387095174096487 1.0126098644220438 0.1783901659528786 0.060968293778169286 529.6576973538964 347516.356751964 0.04049228523970301 0.015303289725744181 5.960644559565888e-09 8.224706774902883 0.07390034701239512 FIVS(ph)PVPESR ddPTM_A459_Selumetinib_30min_R2 2 FIVSPVPESR 10 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4;H0YH68 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 FIVS(1)PVPESR;FIVS(1)PVPESR 114.76 0.0068572 15790800.0 72293.0 68973.0 70451.0 76699.0 75576.0 45011.0 61050.0 52671.0 55473.0 58582.0 True False 68275.24447180839 74263.00731684983 65918.25936124893 66252.46388684511 66081.46722198765 51210.8566808238 63888.94596828006 52824.26388984653 66569.15004512337 56890.58544568464 1.200114991556785 1.305365496506469 1.1586848482018755 1.1645593619369337 1.1615536508246669 0.9001639951432128 1.1230143874908263 0.9285238229843782 1.1701259448046843 1.0 15.79590230704442 -6.581120609489566 8.32074844704796 1.0259999280174277 1.2048996560208436 0.5236045739384905 0.08372034732652385 0.2116535063941482 27.154425978598606 0.026360830592711142 0.026371063200075706 2.623489863358983e-07 6.581120609489566 0.17889972800341591 FIVSPVPES(ph)R ddPTM_A459_Selumetinib_30min_R1 1 FIVSPVPESR 10 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4;H0YH68 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 FIVS(0.063)PVPES(0.937)R 133.91 0.0021906 19334000.0 3408.1 4926.8 4902.2 5469.3 4456.4 4595.4 4749.4 4300.5 2386.2 3020.0 True False 3487.5020989918016 4349.967965592818 4236.5081658571 4514.189426476302 4053.3194068413213 4549.174448289356 4391.148934236126 4186.43677000729 4049.207118847495 3407.646417291097 1.023434262808342 1.2765314920938358 1.2432358428856316 1.3247235404384619 1.1894776953013515 1.3349901636525174 1.2886163634685028 1.2285420073997264 1.1882709128215263 1.0 11.734559931703311 -8.761465749015052 1.9163289411165938 1.0002235587510924 1.2464966742185675 0.4207936715139451 0.08359120815049566 0.8695485548973536 5.311395537408219 0.0783115040455555 0.02182000815943251 1.7319456166534286e-09 8.761465749015052 0.2462731154674751 FKDDDGDEEDENGVGDAELR ddPTM_A459_Selumetinib_30min_R2 2 FKDDDGDEEDENGVGDAELR 20 1 Q6NZY4 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 0 ; 193.72 4.6531000000000014e-15 10363700.0 62282.0 57081.0 59128.0 64954.0 58470.0 41770.0 56020.0 54732.0 38353.0 60803.0 False True 58820.615774600185 61458.929155656646 55323.768853698806 56107.153148100195 51124.47587156789 47523.43834969249 58625.04100152412 54891.26105862966 46024.67167235625 59047.45940483365 0.9961582829723763 1.040839517485245 0.9369373282327872 0.9502043561844972 0.8658200773898634 0.8048345996373589 0.9928461206025242 0.9296125796419318 0.779452192122404 1.0 15.849587366641847 -5.587480811909554 1.7081070492968382 0.8947305254794689 1.0195645599513186 0.2995574860500204 0.06922606771695038 0.46565985357579476 2.6693927797585584 0.021139219495012587 0.0559892830651537 2.5853490634767324e-06 5.587480811909554 0.12483403447184971 FKIPSLGWS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 FKIPSLGWSPSK 12 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 FKIPSLGWS(0.68)PS(0.32)K 95.197 0.010041 14887000.0 79987.0 75569.0 83692.0 81680.0 70343.0 53973.0 69081.0 65852.0 51561.0 67380.0 True False 75541.64275333079 81364.89930736719 78307.34783695986 70555.0430941408 61505.88346560112 61407.290831887774 72293.40338140461 66043.61841761447 61874.640734710716 65434.5643257354 1.1544608500376348 1.2434544364401978 1.1967275803525383 1.0782534249470277 0.9399601586620615 0.9384534223564212 1.1048198169628773 1.00930783444736 0.9455956706106688 1.0 15.997765287578252 -5.910677767461802 3.217113400869606 0.9937673646591306 1.2039277465659883 0.7737247772860653 0.05035150566234896 0.11738360988051426 2.4294230681715465 0.015618238911924768 0.024404050678651538 1.2283502895383826e-06 5.910677767461802 0.2101603819068577 FKIPSLGWSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 FKIPSLGWSPSK 12 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 FKIPSLGWS(0.019)PS(0.98)K;FKIPSLGWS(0.016)PS(0.984)K 107.63 0.0046185 264820000.0 10237.8 10943.0 13802.8 13653.8 11192.6 9835.8 10940.099999999999 10429.5 5866.3 8895.0 True False 10476.320820708974 9661.78847273732 11928.455573353262 11269.420143569043 10180.23130621403 9736.860782191867 10114.879449074957 10152.875780209513 9954.682642400081 10036.759894637176 1.043795102272663 0.9626401920703304 1.1884767294001775 1.1228145598651313 1.0142945943793586 0.970119927586835 1.0077833439534127 1.0115690608115853 0.9918223357837871 1.0 13.29300598764539 -6.425965922156148 6.330090583614079 0.9971191240518785 1.0785021067257867 0.34470053576965776 0.054581595720154315 0.3090582031255273 16.92680474634509 0.018359423785222415 0.020770967256894108 3.7500242645716975e-07 6.425965922156148 0.0813829826739082 FKMPFLSISS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 FKMPFLSIS(0.011)S(0.989)PK;FKMPFLSIS(0.235)S(0.765)PK 154.72 0.00023905 26644000.0 17114.2 15777.9 27347.0 26220.0 16863.2 14978.9 13646.800000000001 14933.9 11667.1 13094.0 True False 17512.92756156377 13930.616133053289 23633.42760631842 21641.16921035757 15337.926537439766 14828.225865753038 12617.410888898296 14537.804459856254 19798.216568730866 14774.7424463608 1.1853287883118002 0.942866935489936 1.5995830514216254 1.4647408771371209 1.038118031033271 1.0036199222819895 0.8539851665574122 0.9839633085067477 1.3400041754100025 1.0 13.850845361079388 -6.3494537898222045 8.636286321853525 1.0241534510092107 1.2940042819102962 0.295507109913172 0.19725534726472463 0.48112611650631637 43.57483717532086 0.06548977449475257 0.07426330732953007 4.4724573748559306e-07 6.3494537898222045 0.2698508309010854 FKMPS(ph)FGVSAPGK ddPTM_A459_Selumetinib_30min_R1 2 FKMPSFGVSAPGK 13 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 FKMPS(0.837)FGVS(0.163)APGK;FKMPS(0.999)FGVS(0.001)APGK 95.554 0.008195399999999999 41861000.0 11187.5 7193.7 11642.5 13226.8 8140.5 8421.4 7464.1 7846.3 3761.5 5845.8 True False 11448.146982914455 6351.458259739603 10061.51244767478 10916.98767778632 7404.19321232201 8336.688362019417 6901.076927618615 7638.190635625666 6382.9907709097515 6596.165372913999 1.735576101521692 0.9629016103539121 1.5253578221356645 1.6550506332990107 1.1224996333060473 1.2638689133314593 1.0462255776601177 1.1579743993367058 0.9676820410113409 1.0 12.6874118537971 -6.356688540510851 8.442718142407672 1.105824945646413 1.4371180935443988 0.4376856115525434 0.20758807398906162 0.35629555335665214 28.749450703877336 0.06383472674485739 0.0723812407587555 4.398569510314648e-07 6.356688540510851 0.3312931478979857 FKMPSFGMLS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 FKMPSFGMLSPGK 13 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 FKMPSFGMLS(1)PGK 86.22200000000002 0.014715 16264000.0 4861.7 5207.5 8756.7 8441.9 7129.6 5945.1 5080.4 5101.6 3686.4 4919.3 True False 4974.968150778564 4597.803479098932 7567.588237110052 6967.680639089155 6484.728938833117 5885.29769171891 4697.181337746496 4966.288995667758 6255.551555996736 5550.74007303976 0.8962711431836359 0.8283226053820658 1.3633476144678853 1.2552705670603368 1.1682638447312261 1.0602726148724049 0.8462261384857409 0.8947075399529674 1.126976128170779 1.0 12.438464421624593 -7.014535856107872 21.392720701022583 0.9574953029348441 1.11049528550879 0.1339047918552424 0.1614305804206134 207.59507604655036 305521.4326343496 0.06592275970812932 0.053207357512697624 9.670838792266017e-08 7.014535856107872 0.15299998257394587 FKVQGEAVSNIQENTQT(ph)PTVQEESEEEEVDETGVEVK ddPTM_A459_Selumetinib_30min_R1 1 FKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVK 37 1 E9PAV3;F8VZJ2;F8W0W4;H0YHX9;Q13765;E9PAV3-2 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alpha 1 FKVQGEAVS(0.001)NIQENT(0.091)QT(0.301)PT(0.301)VQEES(0.301)EEEEVDET(0.006)GVEVK 54.036 0.000281 2690700.0 261.12 285.16 666.79 499.81 419.62 387.07 397.44 227.27 197.8 296.51 True False 267.20358794892735 251.7733346327127 576.2435804152942 412.5275660956835 381.6654450899283 383.1764272314405 367.4607808192203 221.2420613229989 335.6521532595904 334.56994675198115 0.7986479076885142 0.752528244323612 1.7223411307844314 1.2330084339628173 1.1407642820138275 1.145280474087207 1.0983077959827077 0.6612729668962378 1.00323461960082 1.0 8.386164048721955 -7.589371911036475 10.28667624561477 0.8744044687652144 1.144595028921636 0.1471295076388517 0.263215077207602 0.8083597458764158 119.65316687635291 0.13065028950199672 0.07533764319423546 2.5741158512379517e-08 7.589371911036475 0.2701905601564216 FKVQGEAVSNIQENTQTPT(ph)VQEESEEEEVDETGVEVK ddPTM_A459_Selumetinib_30min_R1 2 FKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVK 37 1 E9PAV3;F8VZJ2;F8W0W4;H0YHX9;Q13765;E9PAV3-2 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alpha 1 FKVQGEAVSNIQENT(0.007)QT(0.105)PT(0.444)VQEES(0.444)EEEEVDETGVEVK;FKVQGEAVS(0.001)NIQENT(0.025)QT(0.099)PT(0.394)VQEES(0.394)EEEEVDET(0.087)GVEVK 92.887 3.071e-10 8945400.0 1113.69 1717.59 2019.08 1737.79 1780.61 1484.5600000000002 1341.42 1300.81 814.79 1027.65 True False 1139.6368101364924 1516.4937643140722 1744.9000260125576 1434.3175988584017 1619.5541398922292 1469.6266742726311 1240.2356094165625 1266.3082931736265 1382.6391200929304 1159.5588876586737 0.9828192619329519 1.3078195341817478 1.504796388164276 1.236951063136179 1.396698483474484 1.2674015006172146 1.069575355436055 1.092060357305782 1.1923837028102038 1.0 10.17936037310297 -7.19867202140205 5.16064228490857 1.096170808245364 1.2990131521685948 0.33719664538850924 0.13246942410626236 0.2551420158561897 13.848652945293464 0.052695453345343535 0.04005897808315879 6.328896283258074e-08 7.19867202140205 0.20284234392323075 FLCADYAEQDELDYHR ddPTM_A459_Selumetinib_30min_R1 1 FLCADYAEQDELDYHR 16 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 152.07 0.00025681 2645100.0 1201.3 1807.5 1963.7 1804.1 1856.8 1670.2 1600.7 1582.3 669.59 1372.5 False True 1229.2879526771067 1595.8770597160476 1697.040325831992 1489.0478021512622 1688.852767844666 1653.3993044202653 1479.957910269036 1540.3322639652445 1136.245325081341 1548.673744282128 0.7937681885650684 1.0304798319259945 1.0958023483626875 0.9614987066507641 1.0905155292262778 1.0676227388272033 0.9556292380710926 0.9946137910920999 0.7336892804417214 1.0 10.59681753138343 -8.04558949135441 22.68582185826539 0.8659463632092086 1.0065040308303028 0.20801219895842926 0.10231081696967959 215.68064273106793 107322.04858229133 0.06652156448414534 0.025147536441478338 9.003482165675793e-09 8.04558949135441 0.14055766762109423 FLEESVSMS(ph)PEER ddPTM_A459_Selumetinib_30min_R1 2 FLEESVSMSPEER 13 0 A0A087WTB8;Q5TBK7;P15374 A0A087WTB8 UCHL3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase isozyme L3 1 FLEES(0.028)VS(0.003)MS(0.969)PEER;FLEES(0.032)VS(0.003)MS(0.964)PEER 164.22 0.00036278 18775500.0 3713.3 4450.5 4550.9 4989.9 4802.8 4353.4 4928.6 3927.7 2214.7 3386.6000000000004 True False 3799.812665175979 3929.4333910186842 3932.912776304328 4118.507637023771 4368.387588003209 4309.608748570941 4556.831733961377 3823.524637032352 3758.1841447119064 3821.30309827749 0.9943761506091474 1.028296706636523 1.029207229878506 1.0777757040210316 1.143166997135696 1.127785113542436 1.192481103112558 1.0005813563325725 0.9834823483135804 1.0 11.899848978641035 -1.582667651042736 9.979295224435484 1.0647431205390407 0.00530303342406846 0.0 0.07004698818711462 0.0 0.0 0.017346941121713425 0.0 0.026141611066501164 1.582667651042736 -1.0594400871149723 FLEESVSMS(ph)PEER ddPTM_A459_Selumetinib_30min_R2 1 FLEESVSMSPEER 13 0 A0A087WTB8;Q5TBK7;P15374 A0A087WTB8 UCHL3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase isozyme L3 1 FLEES(0.005)VS(0.003)MS(0.993)PEER 190.57 0.00016479 2974400.0 14100.0 13013.0 13807.0 15824.0 16535.0 13704.0 11246.0 10844.0 10976.0 13831.0 True False 13316.378446772156 14011.055256610083 12918.672651924955 13668.743902077422 14457.725475224472 15591.601607473935 11768.961283526243 10875.55424467916 13171.506695063814 13431.663092746317 0.9914169492505794 1.043136293686272 0.9618073772935535 1.0176508901164398 1.0763913132270473 1.1608094619268763 0.8762102803101125 0.8096952826751911 0.9806311105418509 1.0 13.713350328180036 -7.292033771258254 24.990179304663616 0.9007754181045416 1.038755597560615 0.4221766800245832 0.07075427045190436 640.936523785521 523528.7764883146 0.0302491874058606 0.020396711780376678 5.104653040395544e-08 7.292033771258254 0.13798017945607344 FLEMCNDLLAR ddPTM_A459_Selumetinib_30min_R1 1 FLEMCNDLLAR 11 0 A0A087WYC1;P34932;A0A087WTS8 A0A087WYC1 HSPA4 Heat shock 70 kDa protein 4 0 215.93 0.0030695 8041600.0 911.51 846.79 953.41 996.93 971.93 761.16 913.99 1204.4 459.21 573.79 False True 932.7464095102891 747.6474331380089 823.9421587062577 822.8348901938125 884.019103108179 753.5034214779845 845.046998442429 1172.4553995574418 779.2458306285976 647.4415356878994 1.4406650764524342 1.1547721175219965 1.2726124496026168 1.270902227981959 1.365403753666991 1.16381693163599 1.3052097399722369 1.8109054407695993 1.2035771381282443 1.0 9.338606112332567 -7.544001794997999 24.999856826328926 1.4159561577526525 1.272384640948975 0.0 0.20897417836543075 600.4188291727752 710607.7259121552 0.09188761958663562 0.05305768444202963 2.857578732590053e-08 7.544001794997999 -0.14357151680367752 FLENGS(ph)QEDLLHGNPGSTYLASNSTSAPNWK ddPTM_A459_Selumetinib_30min_R1 1 FLENGSQEDLLHGNPGSTYLASNSTSAPNWK 31 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 FLENGS(0.86)QEDLLHGNPGS(0.074)T(0.026)Y(0.024)LAS(0.011)NS(0.004)T(0.001)SAPNWK 56.347 0.0021167 17487000.0 4339.2 5784.4 6307.7 7093.4 7202.1 4971.5 7516.7 5565.9 2174.5 5588.0 True False 4440.294917386586 5107.159758905396 5451.148985715975 5854.670849609091 6550.671326634033 4921.491223760837 6949.709267270113 5418.274251408806 3689.96768080374 6305.274231729352 0.7042191591036864 0.8099821786029839 0.8645379701781637 0.9285354822708998 1.038919337349325 0.7805356345953911 1.1022057109424106 0.859324123309817 0.5852192220657293 1.0 12.622343402900333 -4.927425051339676 1.7135832403323945 0.9015065323862308 0.6708040318390668 0.16290225976805062 0.13664127173951396 1.285565909313446 4.750627089026015 0.03839612495825207 0.44832154324093554 1.181884259411713e-05 4.927425051339676 -0.230702500547164 FLENGS(ph)QEDLLHGNPGSTYLASNSTSAPNWK ddPTM_A459_Selumetinib_30min_R2 2 FLENGSQEDLLHGNPGSTYLASNSTSAPNWK 31 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 FLENGS(0.857)QEDLLHGNPGS(0.096)T(0.033)Y(0.01)LAS(0.002)NS(0.001)T(0.001)S(0.001)APNWK;FLENGS(0.998)QEDLLHGNPGS(0.001)T(0.001)YLASNSTSAPNWK 79.782 1.098e-05 25548000.0 79882.0 74503.0 85776.0 97758.0 100570.0 74817.0 68230.0 76811.0 75095.0 82336.0 True False 75442.47823298252 80217.14053509744 80257.26554584735 84443.19175804361 87935.49749279248 85122.36262889492 71402.83019518008 77034.50729325437 90116.09832961176 79958.74574538082 0.943517529317183 1.003231601337763 1.003733422750491 1.0560844967096281 1.0997608413320124 1.0645785127740377 0.8929958759302449 0.9634281600484538 1.1270324151478794 1.0 16.286968221302935 -4.679837617990833 1.7024505770345297 1.0251918705419263 0.9004436542559432 0.13355141772529933 0.06383131097532643 2.973220722050819 7.0365664554624425 0.01887145763893079 0.6599395539337783 2.0900774613812973e-05 4.679837617990833 -0.1247482162859831 FLENGSQEDLLHGNPGS(ph)TYLASNSTSAPNWK ddPTM_A459_Selumetinib_30min_R1 1 FLENGSQEDLLHGNPGSTYLASNSTSAPNWK 31 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 FLENGSQEDLLHGNPGS(0.78)T(0.193)Y(0.024)LAS(0.003)NSTSAPNWK 171.25 3.1789999999999995e-28 13762000.0 7322.0 9317.7 10006.0 11134.0 11296.0 9272.8 11463.0 10221.0 3908.9 8553.0 True False 7492.588353868126 8226.779352318792 8647.24015902374 9189.655911064883 10274.278794470782 9179.524051028757 10598.336681085748 9949.905877512963 6633.117805239699 9650.860863275073 0.776364767870612 0.8524399500592312 0.8960071315430043 0.952211003894457 1.0645971318028253 0.951161163866747 1.0981752644902543 1.0309863563960249 0.6873084069091754 1.0 13.236441922149977 -5.315155036769471 1.4624079115825503 0.979798300290834 0.7805964319905101 0.26171879181163116 0.10596964802465021 0.7274829878897919 2.5765227606904073 0.032485663698521 0.15695482618731604 4.839995559873792e-06 5.315155036769471 -0.19920186830032394 FLEQS(ph)MDIEDLK ddPTM_A459_Selumetinib_30min_R1 1 FLEQSMDIEDLK 12 0 O95239;O95239-2;Q2VIQ3 O95239 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 1 FLEQS(1)MDIEDLK 109.99 0.0074068 5031000.0 671.74 660.69 849.63 596.25 652.53 592.73 642.35 545.7 398.09 777.07 True False 687.390235021493 583.336107653552 734.2549126835239 492.126130498692 593.5087767135283 586.7676743557798 593.8970223410485 531.2262633165857 675.5296546567761 876.8145038027782 0.7839631210937492 0.6652902126089394 0.8374119149478392 0.5612659557572578 0.6768920611366006 0.6692038872657169 0.6773348522011147 0.6058593476871528 0.7704362230859298 1.0 9.776127852570518 -8.583145014610716 7.0451998767330615 0.9999976990999698 0.6841202379323615 0.6209759558568684 0.07440704959024692 0.6078423672575056 70.72034735674045 0.06971412316832425 0.018035774298237744 2.6112892771745827e-09 8.583145014610716 -0.3158774611676083 FLEQS(ph)MDIEDLK ddPTM_A459_Selumetinib_30min_R2 1 FLEQSMDIEDLK 12 0 O95239;O95239-2;Q2VIQ3 O95239 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 1 FLEQS(1)MDIEDLK 120.3 0.0031475 0.0 2645.7 2863.1 2478.2 2926.0 2764.3 2616.6 2935.7 3569.2 2675.8 2835.7 True False 2498.662585576245 3082.690563682498 2318.755310060145 2527.4737523684635 2417.0239208444505 2977.012898870132 3072.215866979192 3579.585781087133 3211.034768098739 2753.8259729665756 0.9073422250007126 1.1194209779210018 0.8420122886568071 0.9178044572096643 0.8776966825687598 1.08104612567915 1.1156172892325613 1.2998591110065691 1.1660267568177638 1.0 11.42722167642581 -7.017667305051566 2.7570401578741945 1.170372382974624 0.9378982532470065 0.5031286599676921 0.0987491285670673 0.21637777444890646 3.307703296779387 0.040213838718845464 0.03194571197182411 9.601358700381598e-08 7.017667305051566 -0.2324741297276175 FLES(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 FLESPSR 7 0 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 FLES(0.953)PS(0.047)R 101.25 0.020043 6292500.0 3878.3 4455.0 4786.7 5202.6 4969.4 3780.4 4434.0 3571.8 2147.4 3195.6 True False 3968.6568441418663 3933.4065289266887 4136.692431461017 4294.063574897267 4519.91864741883 3742.372608328564 4099.539810166119 3477.0642611584763 3643.9809601094257 3605.7863877799414 1.1006355943856512 1.0908595534824403 1.1472372421950239 1.1908812983070507 1.2535181403803883 1.0378797315923969 1.1369336309159952 0.9643012334125765 1.0105925776576579 1.0 11.816098216535277 -7.754865140825921 24.9804043033307 0.9905851694438664 1.13823892506 0.5877218007327869 0.05572590010537355 108.62278167529053 412743.1052490359 0.02868907228123603 0.016066285256824218 1.7584695774667287e-08 7.754865140825921 0.1476537556161336 FLESAAADFS(ph)DEDEDDDVDGREK ddPTM_A459_Selumetinib_30min_R1 3 FLESAAADFSDEDEDDDVDGREK 23 1 O43815-2;O43815 O43815-2 STRN Striatin 1 FLES(0.007)AAADFS(0.993)DEDEDDDVDGREK;FLES(0.003)AAADFS(0.997)DEDEDDDVDGREK;FLESAAADFS(1)DEDEDDDVDGREK 148.72 5.6671e-08 25992700.0 4505.79 3736.33 6588.67 6945.879999999999 4860.37 4878.47 4604.45 4142.5599999999995 2760.6800000000003 3405.5 True False 4610.766140258871 3298.878746627308 5693.964802973711 5732.912448315732 4420.750391668021 4829.397021096357 4257.132629436036 4032.685851868709 4684.672327910447 3842.6290973790815 1.1998988253650886 0.8584952289247364 1.4817888114305278 1.4919244879048943 1.150449413575527 1.2567949960068523 1.1078697739367227 1.0494600831028054 1.219132060157899 1.0 11.907878014329585 -7.284061743060819 7.550247695224412 1.0977968830685476 1.2409837543545512 0.1434904568281551 0.17438695262358764 0.49349023323744456 130.68294613323425 0.07710389824893626 0.053136765072625575 5.199220746587464e-08 7.284061743060819 0.1431868712860036 FLGS(ph)VIMRR ddPTM_A459_Selumetinib_30min_R2 1 FLGSVIMRR 9 1 H7C3E5;O60244 H7C3E5 MED14 Mediator of RNA polymerase II transcription subunit 14 1 FLGS(1)VIMRR 84.198 0.026294 4436700.0 16998.0 19507.0 19193.0 16675.0 16109.0 7981.9 10793.0 11947.0 6290.6 15589.0 True False 16053.31920838531 21003.124175108973 17958.143275758368 14403.836234020551 14085.243403712786 9081.334272525994 11294.895885923772 11981.763792067673 7548.895774049595 15138.905064913757 1.0604016036530157 1.387360848426631 1.1862247103575896 0.9514450465379549 0.9304004050039947 0.5998673109836116 0.7460840686623407 0.7914551112310533 0.498642123831338 1.0 13.885973244414526 -6.094040867274082 1.479145157910328 0.7207760561287111 1.2402044158292211 0.6458593247199638 0.1509105628381615 0.22802779635182008 1.0030948129600186 0.0515414239568216 0.08255234225221617 8.053026583505069e-07 6.094040867274082 0.51942835970051 FLIATGERPR ddPTM_A459_Selumetinib_30min_R1 1 FLIATGERPR 10 1 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 136.99 0.0050592 22794000.0 3770.3 3926.0 3947.9 4356.9 3735.5 3025.7 3424.1 3282.0 2033.9 2971.1 False True 3858.1406542732852 3466.342094852117 3411.7968642624237 3596.049204142141 3397.624684556088 2995.2642051157927 3165.8173802412753 3194.950698561546 3451.37974982144 3352.469625964758 1.150835379504149 1.0339667414151708 1.0176965774240514 1.072656759151781 1.0134691924549013 0.8934500649663096 0.9443239562029533 0.9530140627723414 1.0295036599558207 1.0 11.71100854574977 -6.528406002835981 7.299187717388259 0.9590224447875602 1.0604379812296518 0.5208015792512162 0.04696195753422619 0.110725849419084 37.4629150894782 0.015534038586281726 0.01609261143484431 2.9620609940423616e-07 6.528406002835981 0.10141553644209167 FLIATGERPR ddPTM_A459_Selumetinib_30min_R2 2 FLIATGERPR 10 1 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 ; 126.31 0.0097999 18150200.0 118083.0 115765.0 115111.0 117627.0 110217.0 93009.0 104520.0 102492.0 87289.0 109590.0 False True 111520.41958370178 124643.80325685603 107704.88358338042 101605.99968210695 96370.55510751823 105820.14549836122 109380.387102451 102790.23475153591 104749.23905843902 106425.85195098465 1.0478696438818593 1.1711797554062504 1.0120180539685493 0.9547116402591964 0.9055182865898271 0.9943086530056401 1.0277614423310144 0.9658389655069601 0.9842461877277918 1.0 16.69948911353967 -5.445939280052717 5.490617563107134 0.9750860198814121 1.1082120621374314 0.6213961712144991 0.04106086636324896 0.1342190260546056 7.04292920885319 0.010965235167328195 0.023100440448538474 3.5814650708458853e-06 5.445939280052717 0.13312604225601932 FLIPNASQAESK ddPTM_A459_Selumetinib_30min_R2 2 FLIPNASQAESK 12 0 E7EX29;P63104;B0AZS6;E7ESK7;P63104-2 E7EX29;P63104-2 YWHAZ 14-3-3 protein zeta/delta 0 ; 141.71 0.013423 10725500.0 108327.0 107058.0 114982.0 113668.0 115702.0 82361.0 76634.0 90313.0 78798.0 110511.0 False True 102306.61900733942 115269.00435427352 107584.18330293607 98186.22231176305 101166.48037099621 93705.4801512814 80197.63284739021 90575.79587787809 94559.80180007622 107320.26028793916 0.9532833663732441 1.0740656428246442 1.0024592096057987 0.9148899010152456 0.9426596627660758 0.873138770814295 0.7472739316157152 0.8439766697813084 0.8810992588573047 1.0 16.711562933175685 -6.160561192919275 1.2821936824368532 0.8548636725288085 1.018309027067772 0.4126401538560086 0.06759851650928636 0.38449874014921415 1.2841528342567041 0.026055811068498642 0.04116719995285618 6.909375681272068e-07 6.160561192919275 0.16344535453896347 FLIVAHDDGR ddPTM_A459_Selumetinib_30min_R1 2 FLIVAHDDGR 10 0 Q16658 Q16658 FSCN1 Fascin 0 ; 109.83 0.013812 33738000.0 14461.9 15866.6 17354.9 18101.7 16860.4 14581.7 14953.5 14617.3 7904.9 12143.2 False True 14798.834132041178 14008.931095817776 14998.199903641927 14940.577905992737 15335.379796945384 14435.021337124284 13825.545455868083 14229.601720318002 13414.037948947107 13701.898004784503 1.0800572392871148 1.022408070102847 1.0946074695932473 1.0904020669819396 1.1192157313965183 1.0535052393532476 1.009024111188129 1.0385131837464585 0.978991227657885 1.0 13.742088130576784 -7.123646077066248 3.6390368818581935 1.0097539207466488 1.0798329392561739 0.6317230968698877 0.02674696307778123 0.18010159048115493 4.291536150873175 0.011294380831608709 0.008602994412813736 7.522356694821629e-08 7.123646077066248 0.07007901850952503 FLIVAHDDGR ddPTM_A459_Selumetinib_30min_R2 2 FLIVAHDDGR 10 0 Q16658 Q16658 FSCN1 Fascin 0 ; 99.788 0.025459 24602000.0 144139.0 128454.0 156121.0 149114.0 164732.0 124411.0 120868.0 132285.0 115128.0 122444.0 False True 136128.33141413415 138306.00875529044 146076.3448316924 128804.41596400259 144036.89343723498 141547.48595938706 126488.60149539825 132669.92744903947 138156.81694508952 118908.72357228205 1.1448136631572257 1.1631275200024933 1.228474584902055 1.0832209117584646 1.211323182269954 1.1903877336076474 1.0637453476532237 1.115729136293287 1.1618728449398161 1.0 16.859495034707948 -13.430757449007077 0.18504929214610022 0.5867872640634678 1.1845631406380743 0.481589973193276 0.04860910495489782 74.78592216484202 1.042987926632292 11.639729751350625 0.14723969143608256 3.708878026743987e-14 13.430757449007077 0.5977758765746065 FLLGPPQGGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 FLLGPPQGGSPR 12 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 FLLGPPQGGS(1)PR 101.72 0.012273 5888200.0 19219.0 15325.0 19069.0 16974.0 18294.0 14272.0 18676.0 15753.0 15104.0 16296.0 True False 18150.884919752752 16500.378222358384 17842.121300757382 14662.111918216768 15995.744169564947 16237.838451683298 19544.47100579193 15798.838621950461 18125.22204102074 15825.492137907166 1.1469396819752302 1.0426455037587519 1.1274291595658967 0.9264869484277379 1.010758087658454 1.0260558287971613 1.2349992553455325 0.9983157859658051 1.1453180655029982 1.0 13.949962744535021 FLMECRNS(ph)PVTK ddPTM_A459_Selumetinib_30min_R1 3 FLMECRNSPVTK 12 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 FLMECRNS(1)PVTK;FLMECRNS(0.999)PVT(0.001)K;FLMECRNS(1)PVTK 160.22 0.018741 387511000.0 8284.9 7134.7 14110.0 13821.4 10714.4 9067.8 8184.1 7011.9 5099.5 4920.8 True False 8477.922050390882 6299.366007167958 12193.93950068208 11407.751949810689 9745.284411780955 8976.58616490365 7566.766747943285 6825.921634138841 8653.479047256224 5552.432612651001 1.5268842761052637 1.1345236307443152 2.1961436277315034 2.0545502747423843 1.7551378092507965 1.616694301602301 1.3627840760647327 1.2293569522277936 1.5585023089770795 1.0 12.438904263207117 -7.199327508454699 2.5259969694912936 1.2936648080398865 1.7414980604583834 0.33821358704839033 0.29687418171831403 0.3969604174718055 4.9693873301147855 0.14506963031771594 0.10123876384361638 6.319351192046525e-08 7.199327508454699 0.4478332524184969 FLMECRNS(ph)PVTK ddPTM_A459_Selumetinib_30min_R2 1 FLMECRNSPVTK 12 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 FLMECRNS(1)PVTK 74.649 0.028135000000000004 149830000.0 125880.0 188360.0 173570.0 179760.0 169520.0 103950.0 40447.0 43417.0 24163.0 137100.0 True False 118884.0935375658 202806.6063271404 162402.69516872705 155276.37789670366 148223.38207197166 118268.168935852 42327.86564421003 43543.33628192871 28996.275170629266 133141.56677142094 0.8929149357365417 1.523240346685429 1.2197745535587843 1.1662501926485815 1.1132765346410813 0.888288847756285 0.31791623510694467 0.32704539489673 0.2177852933067133 1.0 17.022601525123086 -7.0154133326041235 2.425333694841457 0.4080880373402162 1.209212148557617 0.6442861081449887 0.2486882636243357 0.16499710754860125 1.9424684178582332 0.10019742220806516 0.07875148615553784 9.651318933966754e-08 7.0154133326041235 0.8011241112174008 FLMPEAYPS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 FLMPEAYPSSPR 12 0 O43166-3;O43166-2;O43166 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 FLMPEAYPS(0.599)S(0.401)PR 85.92399999999998 0.030593 10300000.0 1633.1 2066.4 1994.0 1992.3 1891.8 1447.2 1612.6 1528.5 887.81 1398.2 True False 1671.1480525405668 1824.4649273567027 1723.225752257978 1644.3822051027998 1720.687024024417 1432.6424819524657 1490.9602836882923 1487.959214732273 1506.548726923139 1577.6725896213284 1.0592489617517373 1.1564281076814609 1.0922581552054378 1.042283561190274 1.0906489948192704 0.9080733806095518 0.9450378319915866 0.9431356192157789 0.9549184899540781 1.0 10.623582122244512 -6.7521854458540975 24.991494957025918 0.9463543380397639 1.0896429843329964 0.7974094933222325 0.034732621262669267 83.19553500087119 224680.37987986134 0.011674951575533422 0.0115206929009649 1.7693532745427058e-07 6.7521854458540975 0.14328864629323257 FLMPEAYPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 FLMPEAYPSSPR 12 0 O43166-3;O43166-2;O43166 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 FLMPEAYPS(0.061)S(0.939)PR;FLMPEAYPS(0.094)S(0.906)PR 151.16 0.00052989 6887600.0 37824.0 33662.0 45024.0 46497.0 51864.0 36414.0 36126.0 38066.0 32199.0 39952.0 True False 35721.89350146876 36243.76715961029 42127.2048584247 40164.028388201106 45348.38064995721 41429.697966619664 37805.930582310946 38176.76575783445 38639.699715229544 38798.48195223778 0.9207033807519479 0.9341542590307417 1.0857951842106783 1.0351958728087445 1.1688184271173954 1.0678174990872322 0.9744177782226455 0.9839757597947084 0.9959075141856399 1.0 15.243712585497345 -5.220228995073599 10.29110339055521 1.041631439782633 0.9271908666273329 0.39348166516348215 0.05532624885889974 0.7794271290617939 190.48451721231905 0.015587565339804894 0.04113066919478254 6.022419518170209e-06 5.220228995073599 -0.1144405731553001 FLPISS(ph)TPQPER ddPTM_A459_Selumetinib_30min_R1 1 FLPISSTPQPER 12 0 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8 J3KNG6 SPIRE1 Protein spire homolog 1 1 FLPIS(0.143)S(0.791)T(0.066)PQPER 109.16 0.007756999999999998 18044000.0 2978.9 3988.0 3851.4 4161.0 3455.8 3560.0 3731.7 3172.4 1974.9 2735.4 True False 3048.30257406962 3521.0831060290984 3328.4010342258653 3434.3594616437013 3143.2235001710433 3524.1896322213784 3450.214864591094 3088.2576465925167 3351.2610590109466 3086.515235052338 0.987619480847283 1.1407956345206218 1.0783685745097011 1.1126980429712554 1.0183729095112481 1.1418021178701938 1.117835034607431 1.0005645238748186 1.0857749934139298 1.0 11.591763197189428 -8.643049670828658 0.8951029522470344 1.0027133854999002 1.084517900800065 0.1480647274045096 0.0536175303138297 1.3106977413827392 2.240482733640271 0.049436337452491645 0.016988055666789525 2.2748372397788658e-09 8.643049670828658 0.08180451530016475 FLPISS(ph)TPQPERR ddPTM_A459_Selumetinib_30min_R1 1 FLPISSTPQPERR 13 1 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8 J3KNG6 SPIRE1 Protein spire homolog 1 1 FLPIS(0.061)S(0.469)T(0.469)PQPERR 90.853 0.01056 11888000.0 3304.5 3835.5 4586.0 4362.5 3878.2 3598.5 3929.9 3418.2 2125.5 3034.1 True False 3381.488420562307 3386.4378769244263 3963.2463890948275 3600.671269267157 3527.417494751821 3562.302357176581 3633.4644790193574 3327.5382321215952 3606.8182596221386 3423.556289636726 0.9877122309331497 0.9891579370771093 1.1576402003646822 1.051734209881861 1.0303372272363354 1.0405268836852037 1.0613129072882588 0.9719537085440125 1.0535297084321809 1.0 11.741280017878507 -7.736077707323025 24.997354647762123 1.0095562212277391 1.0471023577283063 0.10995147125661742 0.04805205671490978 511.0100930762989 503669.8489977674 0.023438031106352935 0.013524913228906303 1.836209765119996e-08 7.736077707323025 0.03754613650056715 FLPISS(ph)TPQPERR ddPTM_A459_Selumetinib_30min_R2 2 FLPISSTPQPERR 13 1 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8 J3KNG6 SPIRE1 Protein spire homolog 1 1 FLPIS(0.052)S(0.599)T(0.349)PQPERR;FLPIS(0.259)S(0.371)T(0.371)PQPERR 131.24 0.00079276 8866500.0 42177.0 43940.0 45936.0 44029.0 47956.0 42662.0 35594.0 33924.0 26457.0 41240.0 True False 39832.97118790845 47310.056710631485 42980.52777133518 38032.17424573856 41931.33854792046 48538.30325292269 37249.19152817294 34022.71322357947 31749.139270344684 40049.294045611896 0.9945985849973515 1.181295646728513 1.073190646566327 0.9496340735101086 1.0469932004335736 1.2119640160858445 0.930083598620991 0.8495209225119227 0.792751533502333 1.0 15.289489191824604 -7.474460151333366 7.691179211426886 0.8702591218752956 1.0739590907779668 0.5178601072002874 0.0873689542553691 0.2170044465572568 31.179154794372742 0.03735903999133577 0.02481055472115304 3.35382076003013e-08 7.474460151333366 0.20369996890267117 FLPISST(ph)PQPER ddPTM_A459_Selumetinib_30min_R1 2 FLPISSTPQPER 12 0 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8 J3KNG6 SPIRE1 Protein spire homolog 1 1 FLPIS(0.005)S(0.027)T(0.968)PQPER;FLPIS(0.003)S(0.02)T(0.977)PQPER 155.86 0.0010054 20598000.0 4557.799999999999 5689.9 5891.7 6086.6 5385.1 5275.799999999999 5675.9 5215.6 2990.3 4238.8 True False 4663.987872065029 5023.7238628372515 5091.639500791541 5023.6895696324345 4898.018655816626 5222.730242043129 5247.762293306694 5077.265345343569 5074.3206971291875 4782.891269408441 0.9751398493827523 1.0503529308661448 1.0645526343778429 1.0503457608924018 1.0240706677035591 1.0919608972605994 1.0971945623919126 1.0615473067134007 1.0609316439168794 1.0 12.223667279233588 -4.760476802108491 3.941911891718287 1.0598117983753585 0.9653329717275819 0.4379678665705048 0.02720876103143942 0.23535604408654937 6.694568061220179 0.006847627270534461 0.06609783071981003 1.73589398337909e-05 4.760476802108491 -0.09447882664777663 FLPISST(ph)PQPER ddPTM_A459_Selumetinib_30min_R2 1 FLPISSTPQPER 12 0 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8 J3KNG6 SPIRE1 Protein spire homolog 1 1 FLPIS(0.272)S(0.272)T(0.455)PQPER 96.067 0.040831 9394700.0 48069.0 46364.0 53065.0 46820.0 49607.0 44402.0 45073.0 46223.0 40302.0 45980.0 True False 45397.51741545321 49919.969716243 49650.8556728035 40443.03523099504 43374.92516779319 50517.972458775315 47168.98381045514 46357.50127737041 48363.52613196627 44652.43792961284 1.0166861994638425 1.1179673950822921 1.1119405339316486 0.9057296108836604 0.9713898541478645 1.1313597823798225 1.0563585326474048 1.0381852240732146 1.0831105394111593 1.0 15.446451325174674 -6.750645797089108 24.99965869706914 1.063849134890186 1.0281543734710232 0.07213522077976309 0.06568729664411925 732.9230194168978 1697565.3762811949 0.023614992204712332 0.02339354338446297 1.7756370687363572e-07 6.750645797089108 -0.035694761419162724 FLPISST(ph)PQPERR ddPTM_A459_Selumetinib_30min_R1 1 FLPISSTPQPERR 13 1 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8 J3KNG6 SPIRE1 Protein spire homolog 1 1 FLPIS(0.05)S(0.415)T(0.535)PQPERR 108.71 0.0077157 12348000.0 7014.1 8274.3 7918.0 7289.6 6041.6 7733.5 6662.6 6418.2 4460.5 5562.7 True False 7177.514882937229 7305.54110938229 6842.779090460721 6016.608202739227 5495.138346731114 7655.708011456191 6160.034717909965 6247.968486748235 7569.142717969678 6276.7267302864775 1.1435124056467627 1.163909378774063 1.0901827313021175 0.958558251979949 0.8754783476897217 1.2196975175796407 0.9814087792266868 0.9954182737636994 1.2059060467690959 1.0 12.615796684368087 -5.513171133012326 5.930987528293 1.0317794424230518 1.1484571602989815 0.18639197543585684 0.10029855540452247 0.2613430564498178 35.53656952976193 0.027101957943934964 0.052365228923317575 3.06781288366156e-06 5.513171133012326 0.11667771787592973 FLPLNIRNS(ph)PFTR ddPTM_A459_Selumetinib_30min_R1 1 FLPLNIRNSPFTR 13 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 FLPLNIRNS(0.998)PFT(0.002)R 85.92399999999998 0.014934 40669000.0 4210.1 3837.5 6755.8 6653.4 5389.1 4913.0 3797.4 3610.7 2094.4 3085.5 True False 4308.187138571455 3388.20371599465 5838.399466953084 5491.508589786156 4901.6568565228845 4863.57968064709 3510.9590606957213 3514.932506793469 3554.043831076272 3481.5539803151228 1.2374322394339299 0.9731871845594583 1.6769521598584085 1.5773153657347885 1.4078933959482154 1.3969565625424762 1.0084459642294379 1.009587249448686 1.0208211192964436 1.0 11.765515676736959 -7.262492639966394 24.388192458499457 1.01051249557607 1.3838435930341992 0.5089473107960489 0.17731079593223567 63.11878246650319 1461476.0323488892 0.07847209744719308 0.05630816967396211 5.4639580962981954e-08 7.262492639966394 0.3733310974581292 FLPSELRDEH ddPTM_A459_Selumetinib_30min_R1 1 FLPSELRDEH 10 1 Q9Y490 Q9Y490 TLN1 Talin-1 0 121.6 0.013315 3763900.0 785.99 1136.2 1709.0 1959.1 1841.5 1160.3 1209.2 1073.4 560.39 687.72 False True 804.3020377296929 1003.1731757949505 1476.9271868650383 1616.9799618616146 1674.9366501432316 1148.6284354681086 1117.9890704674956 1044.9299451054121 950.9409007337814 775.9955609600765 1.036477627184613 1.2927563329792833 1.903267571579605 2.0837489841579195 2.1584358653688276 1.4801997501725441 1.4407158065238133 1.3465669105279479 1.2254463151274462 1.0 9.599904589353105 -7.842159480906617 1.2086814974480011 1.07969621043906 1.6917251282203296 0.31254609970942426 0.3261597164145433 0.6600321430272891 1.7401741241091948 0.32268811810596554 0.12040203007773256 1.4382703220027995e-08 7.842159480906617 0.6120289177812697 FLQEHGSDS(ph)FLAEHK ddPTM_A459_Selumetinib_30min_R1 1 FLQEHGSDSFLAEHK 15 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 1 FLQEHGS(0.002)DS(0.998)FLAEHK 64.244 0.036201 5100700.0 2874.6 3689.3 3666.4 4351.8 4537.6 3219.4 4599.3 3413.0 1079.7 2495.3 True False 2941.5725870020924 3257.3550408909596 3168.5230180936064 3591.839823403283 4127.174881178349 3187.0157589813202 4252.371098082326 3322.476153013572 1832.172041832052 2815.596061280288 1.044742400180984 1.156897143622867 1.1253471553205818 1.2756942918047793 1.4658263441744088 1.1319151219199188 1.510291606299775 1.1800258562312378 0.6507226185701296 1.0 11.459224657632847 -8.143049899979225 6.063260516967663 0.8311494921181526 1.2483048463463255 0.5143596026943814 0.16042217212432203 0.17569036644337369 7.856928372256466 0.11136968226770416 0.04101122306092229 7.19366318821586e-09 8.143049899979225 0.41715535422817296 FLQEHGSDS(ph)FLAEHK ddPTM_A459_Selumetinib_30min_R2 1 FLQEHGSDSFLAEHK 15 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 1 FLQEHGSDS(1)FLAEHK 92.932 0.008596 2675300.0 14523.0 12680.0 16607.0 15832.0 18155.0 14033.0 13447.0 12534.0 10012.0 15697.0 True False 13715.869800175316 13652.515227373846 15538.523700334466 13675.654288276653 15874.206592240713 15965.918371109294 14072.312144724998 12570.471864884594 12014.67975865332 15243.78682429607 0.8997678830246099 0.8956117915276799 1.0193348857101987 0.8971297254354099 1.0413558504334275 1.0473721887570788 0.9231506781698143 0.824629208593323 0.7881689698982086 1.0 13.895933717682194 -7.5617823181384445 5.960459783399259 0.8569122614451762 0.9677143973235414 0.24337203707225075 0.0745058736492903 0.2344791315362922 21.824781686850706 0.035693493939187054 0.0205847882766696 2.7429486783613602e-08 7.5617823181384445 0.11080213587836518 FLS(ph)LEYSPAGK ddPTM_A459_Selumetinib_30min_R2 2 FLSLEYSPAGK 11 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 FLS(0.997)LEYS(0.003)PAGK;FLS(0.999)LEYS(0.001)PAGK 137.16 0.0013561 2222100.0 33257.0 32153.0 32680.0 33506.0 34280.0 25982.0 31880.0 34146.0 24190.0 28913.0 True False 31408.709078319247 34619.031711810036 30577.404379293694 28942.424998926064 29973.43993291169 29560.784658887027 33362.483169021565 34245.35920682541 29028.675925072308 28078.20656500429 1.1186152151706863 1.2329502467211708 1.0890084560245497 1.0307789755702883 1.0674983768468158 1.0528017375486713 1.1881985087538822 1.2196419713468325 1.0338507859420285 1.0 14.777163169094901 -5.2894858905503686 23.601635736809815 1.0930091267631397 1.1757827355100765 0.20194221360882025 0.07066794568957652 557.8101426502792 469406.52551968984 0.019361784149180206 0.04032383380252379 5.134688589152817e-06 5.2894858905503686 0.08277360874693684 FLSHS(ph)TDSLNK ddPTM_A459_Selumetinib_30min_R1 3 FLSHSTDSLNK 11 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36 Q12802-4 AKAP13 A-kinase anchor protein 13 1 FLSHS(0.836)T(0.163)DSLNK;FLSHS(0.972)T(0.027)DS(0.001)LNK;FLS(0.005)HS(0.891)T(0.104)DSLNK 105.99 0.007525499999999998 105290900.0 14677.0 15735.8 16189.3 17793.8 20208.300000000003 14942.499999999998 18715.9 16110.3 5766.5 10666.9 True False 15018.945543529435 13893.445220625043 13990.881981459419 14686.446860993918 18380.46283306515 14792.192016704481 17304.144594742458 15683.002510370516 9785.329331503675 12036.100519404758 1.2478248681386215 1.1543144890013048 1.1624098651305825 1.2201997513493874 1.5271111107315802 1.22898541706729 1.4376869457715555 1.302996970246815 0.8129983058655618 1.0 13.555080440040648 -8.254255720210901 24.671136743167924 0.9064991423670143 1.2858432071285084 0.6201026210479201 0.11856166059645276 280.3991635825098 962996.4149000847 0.08814418238995445 0.03172638979308549 5.568577647576957e-09 8.254255720210901 0.37934406476149407 FLSHS(ph)TDSLNK ddPTM_A459_Selumetinib_30min_R2 4 FLSHSTDSLNK 11 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36 Q12802-4 AKAP13 A-kinase anchor protein 13 1 FLSHS(0.962)T(0.038)DSLNK;FLS(0.055)HS(0.923)T(0.022)DSLNK;FLS(0.032)HS(0.862)T(0.106)DSLNK;FLSHS(0.977)T(0.023)DSLNK 133.04 0.0012546 148750000.0 313006.0 289915.0 391216.0 443099.0 519018.0 334054.0 350103.0 373672.0 338650.0 417924.0 True False 295610.37958229496 312150.54827634816 366045.5884837748 382748.1518115896 453814.31876020844 380066.90625971195 366383.48321593343 374759.32365527004 406389.4626715894 405857.44822304277 0.7283601197330731 0.7691137606147932 0.9019067903925987 0.9430605585467703 1.1181618589165585 0.9364541858816463 0.9027393357447612 0.9233767306626279 1.0013108406680127 1.0 18.63061356427376 -5.334471667886472 2.003498296342483 0.9731820657504332 0.7276131488008276 0.7171385387448086 0.056573984846601 0.2084373596269881 1.5439337597566454 0.01741883565427902 0.060439413069368245 4.629438639087017e-06 5.334471667886472 -0.2455689169496056 FLSHST(ph)DSLNK ddPTM_A459_Selumetinib_30min_R1 1 FLSHSTDSLNK 11 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36 Q12802-4 AKAP13 A-kinase anchor protein 13 1 FLS(0.001)HS(0.135)T(0.78)DS(0.085)LNK 108.56 0.023149 8956700.0 2336.1 2511.1 2594.5 2899.7 2700.6 2273.9 2625.5 2222.4 1270.5 2122.9 True False 2390.526584740688 2217.099244621281 2242.1811505683677 2393.3218291103667 2456.3312068296555 2251.0266305360074 2427.4564211978236 2163.4547326274146 2155.9457063514133 2395.394893797107 0.9979676382090379 0.9255673251882083 0.93603821080796 0.9991345624505968 1.0254389425269057 0.9397309129968747 1.0133846521438865 0.9031724740791994 0.9000376981408162 1.0 11.226047796306293 -10.052365884824646 4.9763472640561215 0.9999999971896721 0.9607024805616041 0.0697486714643406 0.04370865724766514 61122245.359402865 150996032.11695793 2.443166485260745 0.011325604180351586 8.864089147561678e-11 10.052365884824646 -0.03929751662806802 FLSHSTDS(ph)LNK ddPTM_A459_Selumetinib_30min_R2 2 FLSHSTDSLNK 11 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36 Q12802-4 AKAP13 A-kinase anchor protein 13 1 FLSHSTDS(1)LNK;FLSHSTDS(1)LNK 86.49799999999998 0.02208 10022000.0 80055.0 72970.0 76062.0 85911.0 96662.0 68446.0 75135.0 75780.0 59017.0 73249.0 True False 75605.86358555639 78566.5643644693 71168.25373004409 74209.77359525864 84518.4553907558 77873.81520907479 78628.92637717797 76000.50725394566 70822.04907275701 71134.11104624212 1.0628636876674724 1.1044850804896622 1.000479976249085 1.043237519999612 1.1881564856530353 1.094746445322855 1.1053617627422616 1.068411569866109 0.9956130473988458 1.0 16.118253923023588 -8.199400426162455 3.8588217554662205 0.9962638931693424 1.0857481888380545 0.3627002138617256 0.045800260245257726 0.26217504777846834 7.491226663475259 0.03938682638082111 0.012702079724665817 6.318290266933648e-09 8.199400426162455 0.08948429566871208 FLSLEYS(ph)PAGK ddPTM_A459_Selumetinib_30min_R1 2 FLSLEYSPAGK 11 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 FLSLEYS(1)PAGK;FLS(0.003)LEYS(0.997)PAGK 180.24 1.2516e-08 6084800.0 2860.4 2923.7 3404.5 3757.7 3029.6000000000004 2737.0 2855.4 2636.8 1344.1 2857.5 True False 2927.041754630481 2581.3918448087466 2942.187599579883 3101.48823576509 2755.5732149193245 2709.468264997167 2640.0148791042716 2566.8634984665096 2280.8395308200975 3224.2879594070555 0.9078102798140778 0.8006083443252577 0.912507702978536 0.9619141574239082 0.8546299988125355 0.8403307332064213 0.8187900436751836 0.79610243588124 0.7073932476054473 1.0 11.65476488059271 -6.734503920435473 2.59301648440453 0.8160646407300494 0.890972041883298 0.10861727565438395 0.07787930247932236 0.5279311065539866 7.2718896681742935 0.028569412731436025 0.026902458132760723 1.8428758530039986e-07 6.734503920435473 0.07490740115324868 FLVHNVK ddPTM_A459_Selumetinib_30min_R1 1 FLVHNVK 7 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 98.133 0.030985 7804900.0 8595.9 8125.6 8971.1 8783.6 8795.3 7790.4 8087.0 8459.2 5918.6 7796.0 False True 8796.167745290219 7174.250974511045 7752.873894724954 7249.70914859255 7999.766667936331 7712.035649117249 7476.991079118948 8234.834536645896 10043.431922559212 8796.692539470649 0.9999403418753042 0.8155623198514977 0.881339646684013 0.824140336389296 0.9094061923889551 0.8766971920995809 0.8499775393501345 0.9361284937146885 1.1417281981261092 1.0 13.102745472748758 -8.071997570022369 4.85415593660064 1.0677156798208065 0.8768276950228785 0.6272886725166394 0.05810142760679421 0.12794046985875054 5.559093206606707 0.038086750260998684 0.013961434931902137 8.47232154586332e-09 8.071997570022369 -0.190887984797928 FLVHNVK ddPTM_A459_Selumetinib_30min_R2 2 FLVHNVK 7 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 ; 103.29 0.026319 9987700.0 205746.0 189912.0 214072.0 234480.0 233690.0 181817.0 194413.0 199291.0 179041.0 192719.0 False True 194311.46098649543 204477.63973667333 200298.84058397057 202543.41949943834 204331.77298489297 206860.6413796038 203453.58972205117 199870.903815599 214854.20282351633 187154.7017259041 1.038239804795675 1.0925594593724897 1.0702314114305107 1.082224585498641 1.0917800680430962 1.1052922500582425 1.08708778270512 1.0679448711276212 1.1480032339138309 1.0 17.51387176671124 -4.756302747909229 24.934329059106872 1.0856228748523282 1.0382397286875482 0.12268244340742784 0.03501228539697129 293.90930506990895 1426532.217381058 0.007931356616251342 0.06367050219690924 1.7526582928453705e-05 4.756302747909229 -0.04738314616478001 FMDGHIT(ph)FQT(ph)AAT(ph)VKIPTTTPATTK ddPTM_A459_Selumetinib_30min_R2 1 FMDGHITFQTAATVKIPTTTPATTK 25 1 C9JDI8;C9JYP5;E7ETP9;Q9UQV4 C9JDI8 LAMP3 Lysosome-associated membrane glycoprotein 3 3 FMDGHIT(0.998)FQT(0.996)AAT(0.818)VKIPT(0.086)T(0.086)T(0.012)PAT(0.002)T(0.002)K 54.637 0.0087914 17671000.0 7898.8 6716.6 7985.8 8687.9 9624.0 6591.3 7651.1 4009.9 5177.4 8772.2 True False 7459.816317401692 7231.74162272707 7472.002322281619 7504.593032536562 8414.947080348367 7499.191745135934 8006.891310367028 4021.568145125318 6213.0246686427945 8518.923793087215 0.875675906791777 0.8489031946259873 0.8771063697441297 0.8809320537209472 0.9877946187494692 0.8802980197124483 0.9398946985374277 0.4720746707921802 0.729320371862515 1.0 13.05645546905154 -7.699833566161888 24.999982016459743 0.7005094882398352 0.8979560499622926 0.2556647943586591 0.1250905528477157 69.5822633928149 28236.443565548012 0.05543123074763121 0.03200321491286662 1.9960271020387582e-08 7.699833566161888 0.19744656172245745 FMEQSRS(ph)PSVSPSK ddPTM_A459_Selumetinib_30min_R2 1 FMEQSRSPSVSPSK 14 1 H0Y7Q2;Q96JG6-3;Q96JG6 H0Y7Q2 CCDC132 Coiled-coil domain-containing protein 132 1 FMEQS(0.126)RS(0.874)PSVSPSK 62.709 0.044543 8957200.0 67038.0 54710.0 82894.0 69160.0 69879.0 47121.0 38401.0 39115.0 32928.0 57888.0 True False 63312.29633437663 58906.08107962326 77560.69028816301 59740.28869234545 61100.17529381376 53611.4900281508 40186.72259013795 39228.81817416316 39514.520085191434 56216.623028913185 1.1262201982821702 1.047840974889702 1.3796753719673307 1.0626801375390333 1.086870252992409 0.9536590271631485 0.7148547960532816 0.6978152734999237 0.7028974341782933 1.0 15.778709172190373 -6.915857117110713 1.9412267508303165 0.752450915732976 1.1561878992316024 0.6688413568916416 0.11956841732546976 0.1860184633246995 1.428673971672401 0.05080655891578724 0.04173251103047647 1.2137881210864436e-07 6.915857117110713 0.4037369834986264 FMS(ph)SPSLSDLGK ddPTM_A459_Selumetinib_30min_R2 1 FMSSPSLSDLGK 12 0 P85299;P85299-5;F8WEZ7;E9PH80;B1AHC3;B1AHC4 P85299 PRR5;PRR5-ARHGAP8 Proline-rich protein 5 1 FMS(0.804)S(0.188)PS(0.007)LS(0.001)DLGK 116.03 0.0051124 3097600.0 23938.0 17729.0 21008.0 23186.0 21879.0 18390.0 16253.0 18588.0 13730.0 20042.0 True False 22607.621791406513 19088.75729228004 19656.368151780945 20028.02680191906 19130.364419258327 20923.05557220121 17008.796704708526 18642.088002590946 16476.38364825311 19463.335384630293 1.1615492075042382 0.980754681304724 1.009917764007863 1.0290130856880106 0.9828923995403736 1.074998460373016 0.8738891032078677 0.9578054138301565 0.8465344362952353 1.0 14.24847134200848 -7.261475498486272 24.999999999662137 0.9160410213433076 1.0327252156771147 0.4653130169877061 0.06285076271177907 2.990305152341383 2068577.1088253474 0.023829560828427517 0.0172288038747153 5.476769982850979e-08 7.261475498486272 0.11668419433380717 FMS(ph)SPVLSDLPR ddPTM_A459_Selumetinib_30min_R2 2 FMSSPVLSDLPR 12 0 E9PJV4;E9PLJ6;E9PL62;E9PP25;E9PS02;E9PP62;E9PIU0;Q6MZQ0-4;Q6MZQ0 E9PJV4 PRR5L Proline-rich protein 5-like 1 FMS(0.947)S(0.052)PVLS(0.002)DLPR;FMS(0.973)S(0.026)PVLS(0.001)DLPR 94.122 0.021429 442920.0 15741.2 11946.2 15848.0 15333.199999999999 15170.4 11872.2 12992.9 12299.3 10224.3 13900.099999999999 True False 14866.367121016294 12862.435126912738 14828.356933997737 13244.791708754647 13264.558726903251 13507.487784898713 13597.095594942924 12335.088926741271 12269.445690810946 13498.767996202958 1.1013128846423632 0.9528599299232928 1.0984970582625597 0.9811852246427414 0.9826495818458701 1.0006459692246141 1.0072841905844758 0.9137936832613898 0.9089307775540845 1.0 13.720540121131044 -6.599812487346504 0.6465647899883928 0.9438131865437664 1.045859427040147 0.32789154359117956 0.050764530611581815 0.962570409520377 0.8912300745353533 0.03707917767439845 0.04720182793924979 2.512971207409275e-07 6.599812487346504 0.10204624049638045 FNADEFEDMVAEK ddPTM_A459_Selumetinib_30min_R1 1 FNADEFEDMVAEK 13 0 X1WI28;P27635;F8W7C6;A0A087WV22 X1WI28 RPL10 60S ribosomal protein L10 0 186.13 0.0018127 3598900.0 1162.0 1013.3 1184.0 1265.9 1235.0 1245.7 1111.8 1073.5 795.08 1181.2 False True 1189.0723391415956 894.6623649296101 1023.219303246462 1044.8343288860278 1123.294468056959 1233.1693890051044 1027.9360308846854 1045.0272927805659 1349.1926896543741 1332.818525862331 0.8921487179751408 0.6712559493804795 0.7677108949130499 0.7839284258222792 0.8427962594008735 0.925234279893616 0.7712498070355173 0.7840732046430967 1.012285366292796 1.0 10.38026464373746 -8.342447974423528 0.46045067665109396 1.0171417735018313 0.7744439045844848 0.4315837775053284 0.07897119434700968 1.0300031544652894 0.5773191280255774 0.09741441036435575 0.05406805715785234 4.5451898228481914e-09 8.342447974423528 -0.24269786891734657 FNADEFEDMVAEK ddPTM_A459_Selumetinib_30min_R2 2 FNADEFEDMVAEK 13 0 X1WI28;P27635;F8W7C6;A0A087WV22 X1WI28 RPL10 60S ribosomal protein L10 0 ; 141.54 0.011405 5245100.0 15468.7 14689.1 16108.8 18935.1 19830.3 13940.2 16229.1 16493.199999999997 14295.0 12989.2 False True 14609.011580112357 15815.706737099148 15072.377345935303 16356.106715130585 17339.0404288687 15860.336013463819 16983.785307351576 16541.19248140375 17154.39943567212 12614.168046005385 1.1581430917070028 1.2538049817805952 1.1948768472850952 1.2966456967655655 1.3745686886072181 1.2573430095127376 1.3464055057305144 1.3113185444395568 1.3599311007359316 1.0 13.622757437589211 -5.76659914428873 24.4421393805269 1.2970114068716898 1.207427965034055 0.0810497381405555 0.10351103402518357 179.70603911748006 851286.8509622763 0.02670383905896958 0.04102175327833092 1.7115943953617978e-06 5.76659914428873 -0.08958344183763489 FNADEFEDMVAEKR ddPTM_A459_Selumetinib_30min_R2 1 FNADEFEDMVAEKR 14 1 X1WI28;P27635;F8W7C6;A0A087WV22 X1WI28 RPL10 60S ribosomal protein L10 0 85.28 0.033556 2633000.0 8899.8 9695.8 11354.0 13269.0 14298.0 8632.9 6430.1 7308.1 10199.0 9923.6 False True 8405.184744722184 10439.436683089221 10623.4960013005 11461.739309698274 12501.757414258205 9822.003613336374 6729.1123910014285 7329.365361078914 12239.084983869874 9637.079883390743 0.8721713264210149 1.0832572531728537 1.1023563288719667 1.18933737692185 1.2972557626926657 1.0191887721367072 0.6982522166905433 0.7605379896986104 1.2699993288385645 1.0 13.234380348549974 -7.002895594754132 24.938054614514005 0.9045962474915532 1.116226489590368 0.17829867774258001 0.1746170102483976 171.43585279078138 1476488.5485268696 0.06368255237195039 0.055141147147662765 9.933548241681582e-08 7.002895594754132 0.21163024209881476 FNAHGDANTIVCNSK ddPTM_A459_Selumetinib_30min_R2 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 112.12 0.004336199999999999 11682000.0 81521.0 87012.0 92185.0 92883.0 91222.0 78131.0 82935.0 86310.0 76478.0 79748.0 False True 76990.38917441931 93685.54061232286 86253.91746343911 80232.1751678879 79761.8768249729 88892.83604739814 86791.64183258492 86561.14781061027 91775.7369738604 77445.46802981207 0.994123880105966 1.2096968744027643 1.1137374420700292 1.0359828303575247 1.0299101917012001 1.1478119805949072 1.1206807065737547 1.1177044959853453 1.1850368951031713 1.0 16.24089319710251 -6.794344240336028 24.99878524408497 1.1220054490780957 1.0838760251862152 0.05652016201406984 0.07037659060457649 606.284345816441 460608.0131689622 0.024662024071375698 0.021751028266864175 1.6056680274868497e-07 6.794344240336028 -0.038129423891880565 FNDEHIPESPYLVPVIAPSDDAR ddPTM_A459_Selumetinib_30min_R1 2 FNDEHIPESPYLVPVIAPSDDAR 23 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7 O75369-8 FLNB Filamin-B 0 ; 138.25 5.6105e-06 15977400.0 6193.9 6960.099999999999 6693.4 8124.4 7335.599999999999 6179.1 6457.9 6558.200000000001 3700.8 5074.8 False True 6338.205818768615 6145.208256337296 5784.4730442144155 6705.62605387601 6672.096275205371 6116.94386417391 5970.775403714878 6384.255231964144 6279.987304262345 5726.200012738031 1.106878174822599 1.0731738749375108 1.0101765623531758 1.1710429323040112 1.1651874297724805 1.0682378978321858 1.0427116395572604 1.1149200547941494 1.096711133088681 1.0 12.483362348353465 -10.08502702884289 8.86840216001519 0.9999954267100447 1.093899102645204 0.26361769094312193 0.047295975458085476 0.0 0.0 0.04854796542724091 0.01177461113913816 8.221914782726303e-11 10.08502702884289 0.09390367593515936 FNDEHIPESPYLVPVIAPSDDAR ddPTM_A459_Selumetinib_30min_R2 2 FNDEHIPESPYLVPVIAPSDDAR 23 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7 O75369-8 FLNB Filamin-B 0 ; 102.21 5.129e-05 27186000.0 90258.0 86089.0 89237.0 99477.0 105746.0 70511.0 76997.0 77341.0 72509.0 89999.0 False True 85241.82169140146 92691.7494802357 83495.5885738992 85928.06099260361 92461.24209876554 80223.25021487121 80577.51306666102 77566.04950550816 87012.82607073427 87400.49502451558 0.9753013603354465 1.060540325935636 0.9553216895451099 0.9831530241161798 1.0579029566460743 0.9178809592825399 0.9219342870318901 0.8874783773678984 0.9955644535689121 1.0 16.41535383052694 -6.780356674667968 24.99954759073095 0.9361241695502756 1.0053151844486647 0.3128768476102457 0.04496720030654391 266.5571123726691 352257.6389916804 0.015372406462018087 0.013580586658820356 1.6582244917703248e-07 6.780356674667968 0.06919101489838919 FNDFDHR ddPTM_A459_Selumetinib_30min_R1 2 FNDFDHR 7 0 Q9NWH9;Q9NWH9-3;H7C3F4;H0YMM0 Q9NWH9 SLTM SAFB-like transcription modulator 0 ; 114.28 0.019357 10159300.0 10606.6 15033.5 14933.6 15753.5 13791.3 13540.2 13556.7 11355.9 6873.9 9927.9 False True 10853.71314314909 13273.37083111546 12905.699144393044 13002.446954819517 12543.879350051782 13403.99788151795 12534.107204438218 11054.704642838218 11664.506250207774 11202.242670935182 0.968887522077131 1.1848851360410118 1.1520638789478799 1.1607003469541917 1.1197650076441878 1.196545930601498 1.118892669318674 0.9868295989980864 1.0412652709686392 1.0 13.451499965970271 -7.700204107177196 5.942767110085652 1.0107216387905007 1.1362678974585332 0.4460765817632161 0.060749540321529544 0.16885269269834807 11.577985897979392 0.02864393520019536 0.01604560180174999 1.994324813589134e-08 7.700204107177196 0.12554625866803248 FNDFDHR ddPTM_A459_Selumetinib_30min_R2 4 FNDFDHR 7 0 Q9NWH9;Q9NWH9-3;H7C3F4;H0YMM0 Q9NWH9 SLTM SAFB-like transcription modulator 0 ;;; 131.03 0.005736 15809800.0 178166.0 177607.0 190061.0 184215.0 186068.0 144211.0 148129.0 151262.0 136981.0 176403.0 False True 168264.2469750078 191228.88580348488 177832.68218277066 159124.5992114002 162692.47437097464 164074.75623288244 155017.2920120452 151702.14737722796 164381.02756892628 171309.78703996306 0.9822220311076284 1.116275310988946 1.0380766052863397 0.9288704513670295 0.9496974877040845 0.9577663895794066 0.9048945462519479 0.8855427935465179 0.9595542111705477 1.0 17.386248050322692 -5.719176259075536 5.265926339949239 0.9355232177311729 1.0549888335085018 0.5565488887742334 0.04251591722067664 0.12251883836604585 7.869906916437337 0.011362813639654346 0.01953233389400569 1.9090782989884865e-06 5.719176259075536 0.11946561577732895 FNDPSGCAPS(ph)PGAYDVK ddPTM_A459_Selumetinib_30min_R1 2 FNDPSGCAPSPGAYDVK 17 0 O75330-2;O75330;O75330-3 O75330-2 HMMR Hyaluronan mediated motility receptor 1 FNDPS(0.001)GCAPS(0.999)PGAYDVK;FNDPS(0.001)GCAPS(0.999)PGAYDVK 176.67 9.2676e-08 10418800.0 3210.4 3722.4 3616.6000000000004 4983.9 3814.6 3034.2 4166.9 3657.2 2379.0 3284.7 True False 3285.196073649034 3286.5796775031886 3125.485584561786 4113.555424389818 3469.5701035223315 3003.6787028331755 3852.5873782095628 3560.1991757401843 4036.9892447146917 3706.3232406874386 0.8863760282925849 0.8867493373010831 0.843284673676244 1.1098749777763168 0.9361218323954943 0.8104200599287346 1.0394634056513095 0.9605743872139572 1.089216720332769 1.0 11.855772993712307 -4.374600105712503 0.2323542920506575 1.0319630168474845 0.7086048684969255 0.21498844550896667 0.08603112941390331 23.351039058728176 0.9451355367318592 0.14388828173508098 2.2421382488001655 4.220849764393097e-05 4.374600105712503 -0.323358148350559 FNDPSGCAPS(ph)PGAYDVK ddPTM_A459_Selumetinib_30min_R2 2 FNDPSGCAPSPGAYDVK 17 0 O75330-2;O75330;O75330-3 O75330-2 HMMR Hyaluronan mediated motility receptor 1 FNDPS(0.002)GCAPS(0.998)PGAYDVK;FNDPS(0.013)GCAPS(0.799)PGAY(0.188)DVK 107.63 0.0024256 16163700.0 86614.0 93601.0 90852.0 107567.0 95600.0 83019.0 94838.0 95670.0 80576.0 101133.0 True False 81800.34062331359 100779.89572534848 85006.68123217823 92916.1890365749 83589.8733251564 94454.11367855214 99248.15491793197 95948.38386097901 96693.45148154713 98213.02751490938 0.8328868653488537 1.0261357202337484 0.865533660687465 0.9460678627636198 0.851107795373347 0.9617269324501109 1.010539614033031 0.9769415146724136 0.9845277549036805 1.0 16.583626783769475 -6.98979882664978 24.502301320702756 0.9903739141775066 0.9107883673529177 0.3940732596624824 0.0519056660576053 178.39319075966074 428481.7904539017 0.017165638737401005 0.015121570560651028 1.0237671105907862e-07 6.98979882664978 -0.07958554682458896 FNDS(ph)EGDDTEETEDYR ddPTM_A459_Selumetinib_30min_R1 1 FNDSEGDDTEETEDYR 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 FNDS(0.544)EGDDT(0.265)EET(0.192)EDYR 235.75 2.0499e-16 99602000.0 932.92 899.62 860.59 1155.2 904.34 786.01 689.95 784.64 420.41 683.76 True False 954.6552208536813 794.2920721780089 743.726604882494 953.4660057896668 822.5426066741945 778.103453039979 637.9065160180681 763.828798330082 713.4050644684754 771.5272563864099 1.2373577381115282 1.0295061718210996 0.9639667279752042 1.2358163602092305 1.0661225509086023 1.0085236089835243 0.8268100844626292 0.9900217937958731 0.924666054974959 1.0 9.59157331476115 -6.8686349847275086 3.1816288730894917 0.9331542203011575 1.1029656290352905 0.4445498075720713 0.09015621867048594 0.24372710566631176 4.907847360377532 0.03390935065943216 0.029754697431123384 1.353209429107389e-07 6.8686349847275086 0.16981140873413303 FNDS(ph)EGDDTEETEDYR ddPTM_A459_Selumetinib_30min_R2 4 FNDSEGDDTEETEDYR 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 FNDS(0.598)EGDDT(0.127)EET(0.274)EDYR;FNDS(1)EGDDTEETEDYR;FNDS(0.945)EGDDT(0.051)EET(0.005)EDYR;FNDS(0.977)EGDDT(0.001)EET(0.023)EDYR 272.31 1.2086999999999996e-50 512317200.0 83879.6 67931.5 88281.0 88469.1 91692.7 72496.4 79969.3 83914.5 66702.0 73159.2 True False 79217.90762864327 73141.62761580013 82601.09657308536 76419.45596229011 80173.44328286147 82482.12104320442 83688.03090616185 84158.6773022067 80044.26380959789 71046.90380557056 1.1150085842647521 1.0294836748405258 1.162627674798249 1.0756197929669429 1.128457948037636 1.1609530693825572 1.177926502401645 1.1845509486594699 1.1266397199890628 1.0 16.116484158339397 -5.270010433467543 24.831089550063517 1.1349226866832223 1.0722461276593327 0.12155899846019769 0.05589817766438522 876.0167175652159 2537905.867586231 0.014101562732090974 0.030139911775152507 5.370188949019021e-06 5.270010433467543 -0.06267655902388958 FNDS(ph)EGDDTEETEDYRQFR ddPTM_A459_Selumetinib_30min_R1 2 FNDSEGDDTEETEDYRQFR 19 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 FNDS(0.993)EGDDT(0.001)EETEDY(0.005)RQFR;FNDS(1)EGDDTEETEDYRQFR 137.23 9.0172e-05 22575000.0 1142.03 707.5 3839.5 4039.6000000000004 1701.92 1152.61 977.07 735.37 534.28 476.81 True False 1168.6370769964512 624.6655710921731 3318.116988863845 3334.159692683463 1547.9816364983815 1141.0157898861473 903.3688232564298 715.8655987815976 906.63413773273 538.013208022704 2.1721345490595003 1.1610599178186205 6.167352286867689 6.19717070689975 2.877218650797616 2.120795127092859 1.6790829849261022 1.3305725363370413 1.6851521936882825 1.0 9.07149778061416 -6.703599025987959 3.003212130837071 1.5362921932199012 3.9327707768937654 0.3621777379474507 1.4740649165588107 0.3240965944410641 5.9471776627696125 0.5941905054285261 0.5713674970943662 1.978795773164286e-07 6.703599025987959 2.396478583673864 FNDSEGDDT(ph)EETEDYR ddPTM_A459_Selumetinib_30min_R2 2 FNDSEGDDTEETEDYR 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 FNDS(0.1)EGDDT(0.877)EET(0.022)EDYR;FNDS(0.067)EGDDT(0.933)EETEDYR 219.85 2.7374e-39 0.0 31352.0 25051.7 29787.0 31753.0 30179.6 24085.1 27253.0 30309.0 20820.5 28814.6 True False 29609.58135200002 26973.084836088456 27870.536849633452 27428.186623019767 26388.16883895281 27402.603902230745 28520.318500795 30397.194172074942 24985.181773376098 27982.647628678165 1.0581408072928196 0.9639218273414896 0.9959935607047484 0.98018554166082 0.9430190162530852 0.9792713064844887 1.019214438864098 1.086287279725533 0.8928812635931527 1.0 14.772244851703778 -7.248034868421135 23.104104771950922 1.0067863528481904 0.9838507310780067 0.0050462656316608845 0.05221162504930303 1089.0160080760384 1877034.8738269825 0.019444954515612983 0.014954945205599365 5.648916192519072e-08 7.248034868421135 -0.02293562177018371 FNDSEGDDTEET(ph)EDYR ddPTM_A459_Selumetinib_30min_R1 1 FNDSEGDDTEETEDYR 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 FNDS(0.025)EGDDT(0.079)EET(0.896)EDYR 286.85 4.519899999999998e-74 49052000.0 1507.6 1937.9 1720.2 1797.9 1655.4 1262.4 1252.7 1520.8 903.84 1398.2 True False 1542.7241467210583 1711.0097670947314 1486.606288382233 1483.9305157628478 1505.669362284607 1249.701402167491 1158.2078304454437 1480.4634437453988 1533.7504661382618 1577.6725896213284 0.9778481016085484 1.084515113180363 0.942278073512735 0.940582048217634 0.9543611090093138 0.7921170782763256 0.7341243284979907 0.9383844616966682 0.9721601783716045 1.0 10.623582122244512 -5.797735444594044 1.3628597141384826 0.8812554829999187 1.0288092154679467 0.25050039378075717 0.0825928152181266 0.5790132487340166 2.1612940785242785 0.02997089193115575 0.06942734578208952 1.5931789345198246e-06 5.797735444594044 0.14755373246802794 FNEEHIPDSPFVVPVAS(ph)PSGDAR ddPTM_A459_Selumetinib_30min_R2 2 FNEEHIPDSPFVVPVASPSGDAR 23 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5C6 P21333-2 FLNA Filamin-A 1 FNEEHIPDS(0.001)PFVVPVAS(0.816)PS(0.183)GDAR;FNEEHIPDSPFVVPVAS(0.5)PS(0.5)GDAR 134.67 3.9615e-06 4141100.0 17372.5 14198.800000000001 16310.5 19980.5 19490.2 15978.7 16859.1 16259.4 12040.0 16892.6 True False 16407.005997627606 15287.802303662129 15261.100187529666 17259.121431714993 17041.666831401268 18179.620884803244 17643.081555672892 16306.712162111424 14448.336425707756 16404.8667457542 1.0001304034898035 0.9319065214363181 0.9302788266463331 1.052073247481994 1.0388177542381978 1.1081846117103251 1.0754785045870097 0.994016739961135 0.8807347630206859 1.0 14.001836254660255 -3.188719436024569 8.402020255834461 1.004598605349972 1.0929576396960816 0.0 0.0674401367930997 0.0 0.0 0.016903898846000458 0.0 0.0006475608194620651 3.188719436024569 0.08835903434610959 FNEEHIPDSPFVVPVAS(ph)PSGDARR ddPTM_A459_Selumetinib_30min_R1 1 FNEEHIPDSPFVVPVASPSGDARR 24 1 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5C6 P21333-2 FLNA Filamin-A 1 FNEEHIPDSPFVVPVAS(0.794)PS(0.206)GDARR 85.881 7.0038e-05 3468400.0 1447.8 1445.9 3092.4 2523.4 1998.6 2069.6 1443.0 1547.2 1417.5 1388.0 True False 1481.530923071602 1276.613355819327 2672.4690653372973 2082.7355600845276 1817.8269828814891 2048.7817030464507 1334.1533482340349 1506.1632299861133 2405.393969896206 1566.1633202649134 0.9459619593319323 0.8151214750728489 1.7063795523478704 1.329832931939842 1.1606880070298207 1.3081532918928935 0.8518609336402831 0.9616897615322447 1.5358512990135271 1.0 10.61301895006913 FNEEHIPDSPFVVPVASPS(ph)GDAR ddPTM_A459_Selumetinib_30min_R1 4 FNEEHIPDSPFVVPVASPSGDAR 23 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5C6 P21333-2 FLNA Filamin-A 1 FNEEHIPDSPFVVPVAS(0.354)PS(0.646)GDAR;FNEEHIPDSPFVVPVAS(0.365)PS(0.635)GDAR;FNEEHIPDSPFVVPVAS(0.371)PS(0.629)GDAR;FNEEHIPDSPFVVPVAS(0.384)PS(0.616)GDAR 179.55 6.8642e-17 228790000.0 16705.5 20413.1 21477.5 22021.1 21416.4 17043.9 18152.899999999998 17379.600000000002 10549.699999999999 16320.5 True False 17094.705646755534 18023.124762207273 18560.973467462758 18175.528272242766 19479.290401372513 16872.453840623028 16783.61213801636 16918.636551103064 17902.070380397876 18415.39515013223 0.9282834013275456 0.9786987797586227 1.0079052508047586 0.9869746548507952 1.0577720566171311 0.9162145967039907 0.9113902797733802 0.9187224283363575 0.9721252373055558 1.0 14.168624733888368 -6.802235086575161 24.99986521894017 0.936591878279497 0.9918047681161734 0.26425221851302416 0.039362262288222254 186.34300925601002 114190.8919306481 0.01392076848486443 0.01227708808118511 1.5767575290113177e-07 6.802235086575161 0.05521288983667638 FNEEHIPDSPFVVPVASPS(ph)GDAR ddPTM_A459_Selumetinib_30min_R2 6 FNEEHIPDSPFVVPVASPSGDAR 23 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5C6 P21333-2 FLNA Filamin-A 1 FNEEHIPDSPFVVPVAS(0.421)PS(0.579)GDAR;FNEEHIPDSPFVVPVAS(0.385)PS(0.615)GDAR;FNEEHIPDSPFVVPVAS(0.401)PS(0.599)GDAR;FNEEHIPDSPFVVPVAS(0.378)PS(0.622)GDAR;FNEEHIPDS(0.003)PFVVPVAS(0.438)PS(0.558)GDAR;FNEEHIPDSPFVVPVAS(0.387)PS(0.612)GDAR 131.7 4.8328e-06 76010800.0 183387.0 174719.1 211638.8 216686.9 234667.4 160910.7 179968.1 184973.0 162638.0 201450.2 True False 173195.08469632646 188119.49315954684 198022.19002290283 187173.77041424823 205186.3832588264 183074.68832309946 188336.97325002486 185511.2408060716 195170.1444854029 195633.80929552208 0.8853024194539915 0.9615898899937884 1.0122084252000272 0.9567557422117451 1.0488288501752492 0.9358029114821816 0.9627015592459548 0.9482575709898925 0.9976299351743504 1.0 17.577796191802534 -4.789488096611081 3.7483958214547175 0.9803383742463481 0.8762683843445431 0.45105272289692777 0.03209599719417471 0.22944108231616636 5.671374855901707 0.007929701600943962 0.0654286947443902 1.6237228537873613e-05 4.789488096611081 -0.10406998990180494 FNEEHIPDSPFVVPVASPS(ph)GDARR ddPTM_A459_Selumetinib_30min_R1 1 FNEEHIPDSPFVVPVASPSGDARR 24 1 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5C6 P21333-2 FLNA Filamin-A 1 FNEEHIPDSPFVVPVAS(0.29)PS(0.71)GDARR 59.094 0.047768 0.0 619.18 496.29 965.07 1157.5 1096.0 718.49 686.45 643.99 606.59 464.04 True False 633.6056892854499 438.18413608103845 834.0187947500535 955.3643539660143 996.8669935145165 711.2626429367241 634.6705238359347 626.9092932256699 1029.3389264192867 523.6040541323707 1.210085529867326 0.8368616182835408 1.5928425079367468 1.824593118456817 1.903856522208099 1.3583978911609267 1.212119193552855 1.1972964843912055 1.9658727206093456 1.0 9.032332457520107 -5.269805602553096 24.828784571427274 1.5236142459056803 1.0234735691597354 0.2689465448887627 0.31783430747885827 654.0871590551036 1941165.5417585461 0.0853148108274246 0.1824594323422584 5.372722345591159e-06 5.269805602553096 -0.5001406767459449 FNEEHIPDSPFVVPVASPSGDAR ddPTM_A459_Selumetinib_30min_R2 2 FNEEHIPDSPFVVPVASPSGDAR 23 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5C6 P21333-2 FLNA Filamin-A 0 ; 153.6 3.7305e-08 16710900.0 53289.0 55981.0 56728.0 61689.0 68611.0 42489.0 48038.0 45436.0 46734.0 54848.0 False True 50327.410712768884 60274.56269271414 53078.18224077638 53286.851780539364 59991.47278987762 48341.47407326034 50271.86218549115 45568.21123766529 56082.10585706194 53264.39572778179 0.9448602584356172 1.1316107480268658 0.9965039782304659 1.000421595935723 1.1262959425368473 0.907575753235219 0.9438173755394771 0.8555097756210477 1.0529004429841018 1.0 15.700883873681633 -6.781496394150334 24.998683512980726 0.9424210662735838 1.0404230234409266 0.26412134637017926 0.07255437389584576 295.4303501877239 368216.4108743902 0.024257200305990177 0.021420234734661422 1.6538785164966597e-07 6.781496394150334 0.09800195716734283 FNGGHS(ph)PTHSPEK ddPTM_A459_Selumetinib_30min_R1 2 FNGGHSPTHSPEK 13 0 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 FNGGHS(0.916)PT(0.084)HSPEK;FNGGHS(0.958)PT(0.037)HS(0.005)PEK 78.22800000000002 0.027466 63824000.0 7875.6 8488.8 8340.7 8920.8 8627.099999999999 6804.700000000001 8838.9 7543.1 3900.3 6566.2 True False 8059.08615675004 7494.927349663945 7208.078752185615 7362.9497441555195 7846.780328238216 6736.250896173258 8172.174656760782 7343.032484558072 6618.524233358852 7409.035730204233 1.0877375208079727 1.0115928202518392 0.972876770292876 0.9937797592390011 1.0590825330008113 0.90919400870369 1.1030011130119781 0.9910915201316836 0.8933044021339076 1.0 12.855070075806436 -4.782635440305629 3.540874498077946 0.9935650188872103 1.0987257944045277 0.19909935264392675 0.05825215756322648 0.47318307485776484 9.88909287813182 0.014288629790345432 0.1335889209202424 1.6495464888616003e-05 4.782635440305629 0.1051607755173174 FNHDGEEEEEDDDYGSR ddPTM_A459_Selumetinib_30min_R1 1 FNHDGEEEEEDDDYGSR 17 0 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V5I6;Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 176.49 1.3123e-07 5377800.0 1295.8 1762.8 1512.0 1572.2 1329.5 1176.6 1225.1 1378.7 759.19 1157.9 False True 1325.9896188121156 1556.4105564965128 1306.6787048214953 1297.6447838491297 1209.2469597422896 1164.7644722673235 1132.6897206663314 1342.13239735125 1288.2899809562612 1306.5277439011118 1.0148958757300426 1.191257180539684 1.0001155436010358 0.9932010934375884 0.925542504081578 0.8914961643213923 0.8669465504684011 1.0272513565948684 0.9860410442640926 1.0 10.351522045036495 -5.55005252493429 2.8625819345862453 0.9485825034616995 1.1033977138086175 0.45090194531687844 0.06276285812813573 0.2183737382861636 3.6116272784856105 0.01794821618367921 0.03807156021430064 2.81804208782097e-06 5.55005252493429 0.15481521034691803 FNHDGEEEEEDDDYGSR ddPTM_A459_Selumetinib_30min_R2 2 FNHDGEEEEEDDDYGSR 17 0 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V5I6;Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 ; 199.65 8.395200000000001e-08 24134600.0 59791.0 59756.0 69232.0 70624.0 66367.0 55646.0 48705.0 62078.0 46620.0 60517.0 False True 56468.05558233713 64339.09305417599 64777.68849410227 61004.889366804695 58029.38413149217 63310.73139590585 50969.87900712659 62258.63670243384 55945.302671635814 58769.716967950895 0.960835928699998 1.094766086575885 1.1022290362471496 1.0380327235551043 0.9874028177324309 1.07726793087044 0.86728134210553 1.059365944137277 0.9519409920273169 1.0 15.8427853299449 -6.678412643334139 1.3868917614553098 0.9800728131244041 1.0543216875508323 0.16912404989366392 0.06448890824851473 0.6963971929192101 2.7973788649237084 0.02824623139418024 0.027454502861571733 2.0969465306090073e-07 6.678412643334139 0.07424887442642825 FNNDSHS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 FNNDSHSPK 9 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 FNNDS(0.381)HS(0.619)PK;FNNDS(0.004)HS(0.996)PK 103.46 0.015218 3949800.0 26267.0 19482.7 19636.9 15578.3 15664.199999999999 20300.8 42237.0 85195.0 20271.7 42328.0 True False 24807.185295132214 20976.96044324577 18373.48323304015 13456.508665933576 13696.32315627524 23097.050927685832 44201.10419102773 85442.90334520854 24326.6064386229 41105.88065864842 0.6034948016595513 0.5103153151599575 0.4469794330795948 0.32736213043771417 0.3331961981306833 0.5618916456136394 1.0752988011151658 2.078605347364864 0.5918035582459839 1.0 15.327057181976473 -7.296460441657963 3.69284443732054 1.29996032371684 0.4458257457120151 0.49411234323670483 0.3568303690663653 0.17239230192955757 5.040719036345024 0.14794240829370622 0.09999406275721962 5.052886677944015e-08 7.296460441657963 -0.8541345780048248 FNPFVTSDR ddPTM_A459_Selumetinib_30min_R2 1 FNPFVTSDR 9 0 J3KSS0;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;P61254;E5RHH1;E5RIT6;Q9UNX3 J3KSS0 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 157.99 0.012003 11951000.0 46551.0 51871.0 55173.0 52866.0 54032.0 43119.0 35709.0 43412.0 49843.0 38315.0 False True 43963.88177841778 55849.33890844705 51623.229247820345 45665.559601063265 47244.017107791275 49058.25085468974 37369.53925604116 43538.32173275651 59812.99272977997 37208.74639567456 1.1815469758349206 1.5009734086322084 1.3873950145716663 1.2272802506018259 1.269701929901172 1.3184601903275261 1.0043213726863232 1.170109878730495 1.607498196626509 1.0 15.183354164820726 -5.764501625344173 24.758377825747512 1.231446184375917 1.3710719790584325 0.09799899414980018 0.17676060793201429 155.55442069305656 1257684.5005532857 0.048617435456967735 0.07572908984633256 1.7198809045834967e-06 5.764501625344173 0.13962579468251546 FNS(ph)LPRPDPEPVPPVGSK ddPTM_A459_Selumetinib_30min_R2 1 FNSLPRPDPEPVPPVGSK 18 1 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 FNS(1)LPRPDPEPVPPVGSK 72.207 0.011135 4726200.0 24399.0 21180.0 20979.0 21450.0 19483.0 17025.0 16700.0 18679.0 14467.0 20586.0 True False 23043.00125693572 22804.43789556609 19629.233980208144 18528.4729966861 17035.371359770088 19370.039212437503 17476.58309042222 18733.352797525095 17360.804241753656 19991.62869114856 1.1526325149855439 1.140699352107461 0.9818726769819976 0.9268115811339434 0.8521252381659442 0.9689075118233729 0.8741950623642838 0.9370598607515868 0.8684036958649738 1.0 14.287108390847944 -5.3616224189591515 2.3207271066123387 0.9130399052641484 1.15926638061302 0.812221881151156 0.04330725032722133 0.1137137243870157 1.1618964253169872 0.011289298233816353 0.03344637868201321 4.348881570474125e-06 5.3616224189591515 0.24622647534887154 FNS(ph)YDISR ddPTM_A459_Selumetinib_30min_R2 2 FNSYDISR 8 0 B4DFB6;Q6IQ26-2;Q6IQ26 B4DFB6 DENND5A DENN domain-containing protein 5A 1 FNS(0.999)YDIS(0.001)R;FNS(0.998)YDIS(0.002)R 113.67 0.010648 7662600.0 44737.0 33974.0 42334.0 52778.0 60318.0 24622.0 37707.0 44402.0 34026.0 35378.0 True False 42250.696636400426 36579.696556372175 39610.27652977413 45589.545352871726 52740.31359023824 28013.45700373782 39460.45021500303 44531.20246885317 40832.15076587476 34356.54521691702 1.2297713978411415 1.0647082331887225 1.1529179165043113 1.326953716243379 1.5350878051693375 0.8153746782998459 1.148556991567734 1.296149021611352 1.1884824422267342 1.0 15.068297350571513 -6.75890894702183 24.999999958608733 1.1118997552067436 1.24849421297687 0.2057278397684551 0.16527544989502488 151.23483730051012 1494162.4335097035 0.05990880878005725 0.05725732115938689 1.742172094080487e-07 6.75890894702183 0.13659445777012635 FNVWDTAGQEK ddPTM_A459_Selumetinib_30min_R2 2 FNVWDTAGQEK 11 0 F5H018;B5MDF5;J3KQE5;P62826;H0YFC6 F5H018 RAN GTP-binding nuclear protein Ran 0 ; 172.17 0.0036431 12172500.0 80964.0 64678.0 76822.0 84535.0 80273.0 66015.0 65438.0 68221.0 63245.0 64691.0 False True 76464.34500457162 69638.59462745156 71879.35615746934 73021.18716899105 70188.38809027485 75107.96702549559 68480.99666293705 68419.51181540551 75895.76721294751 62823.202742596506 1.2171354160001444 1.1084852663876361 1.144153004296491 1.1623283115344885 1.1172367059644426 1.195545017550809 1.0900589857464293 1.0890802892641207 1.2080849733801826 1.0 15.939009873368363 FPEAEALS(ph)PEQAAHYLR ddPTM_A459_Selumetinib_30min_R1 2 FPEAEALSPEQAAHYLR 17 0 Q2NKX8 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 FPEAEALS(1)PEQAAHYLR;FPEAEALS(1)PEQAAHYLR 210.61 2.1968e-09 21536000.0 7738.4 13270.800000000001 5934.5 6368.3 8045.6 7468.3 10790.9 9245.9 4721.5 9242.3 True False 7918.6896636947695 11717.048566572466 5128.627495875112 5256.195952796343 7317.876900566049 7393.175682673851 9976.93372519657 9000.66869708415 8012.040655283906 10428.639232625652 0.7593214691828069 1.123545297253746 0.49178300078023324 0.5040155130069615 0.7017096609951099 0.7089300452109366 0.9566860548770413 0.8630722087811664 0.7682728759298243 1.0 13.348263301508931 -7.245946318999565 22.941274204992656 0.8855971268851808 0.7131348941814302 0.21088538089162123 0.17200572975900755 510.4535462765938 755852.164395298 0.07102998792536078 0.0547489604211678 5.676147611357212e-08 7.245946318999565 -0.1724622327037506 FPEAEALS(ph)PEQAAHYLR ddPTM_A459_Selumetinib_30min_R2 3 FPEAEALSPEQAAHYLR 17 0 Q2NKX8 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 FPEAEALS(1)PEQAAHYLR;FPEAEALS(1)PEQAAHYLR;FPEAEALS(1)PEQAAHYLR 149.67 0.00019225 15055300.0 32903.0 25454.0 33977.9 39117.7 43690.5 36352.2 39966.5 48134.9 42561.3 34979.2 True False 31074.382981144947 27406.239952490065 31791.798906340344 33789.801778203626 38201.70879197427 41359.38557758418 41825.02144211734 48274.96458983833 51074.74926208264 33969.259609123845 0.914779519445241 0.8067953281245197 0.9358990826459269 0.9947170520351283 1.1245964507779154 1.2175533424483416 1.2312609083444228 1.4211367908905528 1.503557918241009 1.0 15.051942153260057 -6.42083633222771 0.9901249323506578 1.329490121031511 0.857991827825943 0.6481566504179246 0.1277261444905988 0.308503914846431 0.6488594954419179 0.061811109876065265 0.08090731746243404 3.794579601682912e-07 6.42083633222771 -0.47149829320556813 FPEFCSSPS(ph)PPVEVK ddPTM_A459_Selumetinib_30min_R1 1 FPEFCSSPSPPVEVK 15 0 Q68E01-4;Q68E01-3;Q68E01-2;Q68E01 Q68E01-4 INTS3 Integrator complex subunit 3 1 FPEFCS(0.001)S(0.009)PS(0.99)PPVEVK 131.56 0.00070035 19681000.0 2877.3 2993.9 2647.9 2945.1 3042.6 2646.1 3152.0 2926.5 1631.1 2715.2 True False 2944.3354917488073 2643.3727961736517 2288.329723873571 2430.7935713739157 2767.3973672146603 2619.4826364665714 2914.2421023102397 2848.8797133882877 2767.8575691694546 3063.7223682876756 0.9610320837897612 0.8627977598541481 0.7469115829684416 0.7934118301758831 0.9032794210923778 0.8550000037799146 0.9512095914679825 0.9298752859843942 0.9034296311634853 1.0 11.58106985214617 -7.074985591942853 1.5352762529200046 0.9433052617077285 0.8411967672702987 0.356202993016825 0.059289964055555436 0.48375572029743663 2.2811416764724304 0.032696802561442834 0.022879895440707232 8.414230560463316e-08 7.074985591942853 -0.10210849443742986 FPEFCSSPS(ph)PPVEVK ddPTM_A459_Selumetinib_30min_R2 1 FPEFCSSPSPPVEVK 15 0 Q68E01-4;Q68E01-3;Q68E01-2;Q68E01 Q68E01-4 INTS3 Integrator complex subunit 3 1 FPEFCS(0.043)S(0.234)PS(0.723)PPVEVK 114.01 0.0026204 3060200.0 33835.0 34223.0 35894.0 36430.0 42332.0 27231.0 29177.0 28807.0 26447.0 33894.0 True False 31954.586152236567 36847.794055711 33584.619118432296 31468.171154744727 37013.875707118365 30981.823071593888 30533.788313128676 28890.823600744432 31737.138990921314 32915.39215281206 0.970809826718306 1.1194700000729896 1.0203317330236656 0.9560320900523224 1.1245157139638136 0.9412563863057914 0.9276446767327996 0.877729892040074 0.9642035812175463 1.0 15.006474765625674 -6.899628130504746 10.442944563446515 0.9325386396837283 1.0371214483396685 0.39828291992891185 0.05852986170793856 0.3258596898015906 31.32195193087992 0.019917553923605443 0.01756800383232461 1.260003842366192e-07 6.899628130504746 0.10458280865594016 FPPEDFRHS(ph)PEDFR ddPTM_A459_Selumetinib_30min_R1 5 FPPEDFRHSPEDFR 14 1 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR 90.259 0.01016 113656000.0 12868.6 14892.2 13863.000000000002 13661.400000000001 14969.700000000003 13225.6 14701.399999999998 13035.2 6884.079999999999 11648.5 True False 13168.41334206328 13148.614300804047 11980.480744008202 11275.69294623871 13615.693278115199 13092.562471884012 13592.461561834949 12689.464151703054 11681.780966689988 13143.698440998452 1.0018803612374227 1.0003740088703086 0.9114999707112964 0.8578782446093735 1.0359103519633772 0.9961094687812576 1.0341428345188364 0.9654409075699326 0.8887742684548832 1.0 13.682083665234094 -5.061034409307749 24.997160748118095 0.9623541141494628 1.0015048611603004 0.07341086336233615 0.056609002282468214 632.8500930201598 259188.03953593018 0.01543017205452693 0.04082467593005829 8.688915839668165e-06 5.061034409307749 0.03915074701083754 FPPEDFRHS(ph)PEDFR ddPTM_A459_Selumetinib_30min_R2 4 FPPEDFRHSPEDFR 14 1 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR;FPPEDFRHS(1)PEDFR 84.195 0.014422 24289000.0 49720.2 41844.8 53119.2 54411.0 56987.5 40784.1 37450.28 44840.1 34415.9 47047.0 True False 46956.95032973051 45054.16160776128 49701.568503812 47000.12793578964 49828.220775286034 46401.73957380161 39191.79222632197 44970.577267321845 41300.04166059098 45688.63086721391 1.0277600671861398 0.9861131916757013 1.0878323022692669 1.0287051076751976 1.09060437639515 1.015608012169597 0.8578018531618101 0.9842837575505607 0.9039457054561865 1.0 15.479547590082763 -7.019924248245049 22.9458726755886 0.9354133517263241 1.0435954121557387 0.5481379192365564 0.04638635502699837 192.76356225927512 221996.438829357 0.016663172929897947 0.013116422930305844 9.55159174999402e-08 7.019924248245049 0.10818206042941458 FPQGPPSQMGS(ph)PMGSR ddPTM_A459_Selumetinib_30min_R2 2 FPQGPPSQMGSPMGSR 16 0 Q8WXF1 Q8WXF1 PSPC1 Paraspeckle component 1 1 FPQGPPS(0.001)QMGS(0.976)PMGS(0.024)R;FPQGPPS(0.092)QMGS(0.752)PMGS(0.157)R 198.67 9.1795e-07 30620000.0 11340.8 7567.5 10859.400000000001 13544.8 10544.4 8141.6 10454.099999999999 12969.3 11531.5 8895.9 True False 10710.523736819405 8147.902916652333 10160.718026820741 11699.974873916726 9219.718203867973 9263.031497913731 10940.236364406159 13007.038515816796 13838.122217030641 8639.052252676012 1.2397799461742738 0.9431477757445509 1.176138044965914 1.354312317105452 1.0672140802264618 1.072227742926828 1.2663699725878308 1.5056094274447485 1.6018102231925009 1.0 13.076657334856156 -7.535545062412873 5.065205236133793 1.413310952323939 1.1421925842945937 0.23578015456480217 0.1791598673047538 0.2162926580992301 16.08286107131671 0.08240936325505804 0.04865332673181134 2.9137677864227725e-08 7.535545062412873 -0.2711183680293454 FPSNLEVEASPQASSAEVNAS(ph)PLWNLAHVK ddPTM_A459_Selumetinib_30min_R1 1 FPSNLEVEASPQASSAEVNASPLWNLAHVK 30 0 O94864;O94864-2;O94864-4 O94864 SUPT7L STAGA complex 65 subunit gamma 1 FPSNLEVEASPQAS(0.002)S(0.002)AEVNAS(0.996)PLWNLAHVK 103.46 7.6144e-09 6389000.0 817.47 1108.2 882.44 1156.9 1185.3 856.38 1008.6 889.2 629.87 731.69 True False 836.5154604802751 978.4514288117969 762.6094948959526 954.8691327026186 1078.0898242817118 847.765594730827 932.5204899714819 865.6155274713365 1068.8433861153605 825.6095387641461 1.0132095393815992 1.1851261193959066 0.9236926889646913 1.1565626217593863 1.3058107660620093 1.0268359980431503 1.1294933575590353 1.0484563063153016 1.2946112368266856 1.0 9.689315828956715 FPVFNPATEEELCQVEEGDKEDVDK ddPTM_A459_Selumetinib_30min_R2 1 FPVFNPATEEELCQVEEGDKEDVDK 25 1 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 193.59 1.2694e-26 2542400.0 16499.0 12804.0 12685.0 12793.0 13109.0 8897.7 12811.0 10984.0 7231.2 12930.0 False True 15582.051630730048 13786.025628651007 11868.860910383733 11050.571330844074 11462.130224053071 10123.277409721304 13406.73688451492 11015.961621500906 8677.642056609455 12556.677303825454 1.2409374911612086 1.0979039514259896 0.9452230572786819 0.8800553732058928 0.9128314717907958 0.8062067029975516 1.0676978120979894 0.8772990939366451 0.6910778900056441 1.0 13.61616713426675 -5.024482608504604 1.5586779006352305 0.8889446400286092 1.2920806880714615 0.5884902144177029 0.09560898903536784 0.4781076312190344 1.5480761346525946 0.027592825677064756 0.2575532454812493 9.451862420421615e-06 5.024482608504604 0.4031360480428523 FPYS(ph)PSPPMANGAAR ddPTM_A459_Selumetinib_30min_R2 1 FPYSPSPPMANGAAR 15 0 Q92908-2;Q92908 Q92908-2 GATA6 Transcription factor GATA-6 1 FPYS(0.68)PS(0.319)PPMANGAAR 99.991 0.0078779 3367400.0 7563.6 9354.1 7860.7 6310.5 9658.8 7096.5 5286.5 5839.8 4420.8 6556.5 True False 7143.245391489777 10071.529391827893 7354.951120083037 5450.99901378031 8445.375193232429 8073.978459386948 5532.33272500102 5856.792851169068 5305.083527472491 6367.196809167174 1.1218822985344643 1.5817838985795765 1.1551317385845121 0.8561065688957865 1.3263882751469527 1.2680585666462256 0.8688804336997784 0.9198385139810267 0.8331898143676815 1.0 12.636442643075958 -7.263369028974154 24.944831911434896 0.898797052315217 1.2203393011107166 0.4333713586871023 0.17511742038509412 172.02110118293146 2223711.9576828554 0.07430869610937882 0.052977910927605704 5.452943163556791e-08 7.263369028974154 0.32154224879549964 FPYSPS(ph)PPMANGAAR ddPTM_A459_Selumetinib_30min_R2 1 FPYSPSPPMANGAAR 15 0 Q92908-2;Q92908 Q92908-2 GATA6 Transcription factor GATA-6 1 FPY(0.001)S(0.285)PS(0.714)PPMANGAAR 93.243 0.012674 3154300.0 14367.0 10996.0 14357.0 15359.0 14061.0 10700.0 10266.0 11551.0 9138.4 12627.0 True False 13568.539655657842 11839.357842287296 13433.286250719682 13267.07770424717 12294.531473065095 12173.827875070858 10743.389341693082 11584.61149762901 10966.33534822988 12262.425701113994 1.1065135060859281 0.9654988442630674 1.0954835999128067 1.0819293040072737 1.002618223566336 0.9927748531813663 0.876122685963927 0.9447242968066745 0.8943039179624657 1.0 13.581956774631344 -6.810082457460179 2.0133514381019473 0.925266442782086 1.0557041913913028 0.5764599020370406 0.04949349058421618 0.22452688769767198 1.872074419383245 0.01941933363338221 0.01724747809306504 1.5485225802664117e-07 6.810082457460179 0.13043774860921675 FQCVFSSS(ph)VLQPHS(ph)T(ph)S(ph)CLFK ddPTM_A459_Selumetinib_30min_R1 1 FQCVFSSSVLQPHSTSCLFK 20 0 Q9H334-3;Q9H334-4 Q9H334-3 FOXP1 Forkhead box protein P1 4 FQCVFS(0.098)S(0.407)S(0.494)VLQPHS(1)T(1)S(1)CLFK 80.844 0.010169 0.0 1202.6 978.9 808.62 963.93 1753.5 641.37 1236.3 1058.4 299.85 531.53 True False 1230.6182401477472 864.289932921736 698.813845431718 795.5977207070923 1594.8962346055685 634.9184001173663 1143.0448956491593 1030.3277938322783 508.8235498224885 599.7570530406407 2.0518612226546975 1.4410667261684875 1.1651615298042441 1.3265333299101378 2.659237146974402 1.0586259834685814 1.9058465254458699 1.717908590834798 0.8483827697279445 1.0 9.228234408240787 -8.261005731404031 24.999950687237728 0.9241913039695361 1.6511731588331653 0.30572016701106575 0.44658764121805633 47.64639376580869 2747289.290757711 0.3443632162615596 0.11177456810720601 5.482697293325537e-09 8.261005731404031 0.7269818548636292 FQDGDLTLYQSNTILR ddPTM_A459_Selumetinib_30min_R1 1 FQDGDLTLYQSNTILR 16 0 P09211;A8MX94;A0A087X2E9 P09211 GSTP1 Glutathione S-transferase P 0 202.32 6.8023e-06 13665000.0 566.46 562.42 867.7 978.77 742.54 675.0 856.09 663.09 555.42 616.86 False True 579.6574158607125 496.5716049380357 749.8711059349284 807.8461932883934 675.3773881060844 668.2101128509636 791.5144420579871 645.5026991801261 942.5071737282191 696.0399897252271 0.8327932653546839 0.7134239587786692 1.0773391141376116 1.1606318677283234 0.9703140596457689 0.9600168420132731 1.1371680560630577 0.9273931221034422 1.354099171945981 1.0 9.443026385677632 -5.267597233798308 24.50043636842913 1.0684432489829525 0.773108601854649 0.4932665671811036 0.12165116186128222 265.92871731669266 1058064.0475026835 0.030231157666648786 0.06562084169211001 5.400111986109485e-06 5.267597233798308 -0.2953346471283035 FQELLAS(ph)PAYR ddPTM_A459_Selumetinib_30min_R2 2 FQELLASPAYR 11 0 Q9NSI2-2;Q9NSI2 Q9NSI2-2 FAM207A Protein FAM207A 1 FQELLAS(1)PAYR;FQELLAS(1)PAYR 115.06 0.006285499999999999 4106500.0 21113.1 17438.1 23770.0 22870.0 20540.6 19101.8 19093.9 18206.9 14660.9 19694.0 True False 19939.718424435818 18775.54619767096 22240.664078819173 19755.06654704947 17960.106192706127 21732.899561124155 19981.80418384507 18259.879064685443 17593.489659772327 19125.38304884288 1.0425787746845785 0.9817082434229685 1.1628872489518465 1.0329239679330078 0.9390717114966618 1.1363380019956795 1.044779293194549 0.9547457961000263 0.9199026035108231 1.0 14.223201022368174 -7.758286730505058 6.7909833222184455 0.9524540298349083 1.0491852974811697 0.29490078666137964 0.06390185167272512 0.1678795488324784 38.209393630038186 0.03281663577607236 0.017263258990813088 1.7446699042093273e-08 7.758286730505058 0.09673126764626139 FQENSSDHS(ph)ETR ddPTM_A459_Selumetinib_30min_R2 1 FQENSSDHSETR 12 0 H0YB65;E5RJJ0;Q6P5X7-2;Q6P5X7 H0YB65 TMEM71 Transmembrane protein 71 1 FQENS(0.004)S(0.03)DHS(0.966)ETR 86.31299999999997 0.030060000000000007 4603700.0 2972.2 2474.7 11010.0 13434.0 14581.0 10823.0 5474.6 6816.2 11210.0 8015.7 True False 2807.0170226593045 2664.5015325853346 10301.628586781619 11604.266025057397 12749.204424206104 12313.770008588026 5729.179747714099 6836.034013517348 13452.31323357009 7784.2659137102655 0.3606013789579521 0.34229323125927696 1.323391145803174 1.4907335070117589 1.63781717705085 1.5818794148463042 0.7359948659543367 0.8781860857909779 1.7281415335358483 1.0 12.92634527867609 -5.26098822386456 24.999997360330855 1.3018943832935639 0.3514472131291409 0.5885111147001221 0.31624729476782737 27.6588444486656 1532552.3774679995 0.08752999797548305 0.2047245229024774 5.482918319560207e-06 5.26098822386456 -0.950447170164423 FQEQECPPS(ph)PEPTR ddPTM_A459_Selumetinib_30min_R2 3 FQEQECPPSPEPTR 14 0 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 FQEQECPPS(0.996)PEPT(0.004)R;FQEQECPPS(0.961)PEPT(0.039)R;FQEQECPPS(1)PEPTR 103.39 0.0069195 22170200.0 132552.0 46168.0 87995.0 111293.0 71945.0 63318.0 171038.0 106975.0 91034.0 75778.0 True False 125185.29048769809 49708.937146482305 82333.49750171184 96134.7014088664 62906.62590353951 72039.47975642385 178991.6059053673 107286.2795393353 109243.34370248168 73590.09224511092 1.7011160968617345 0.675484098877248 1.1188122611326363 1.3063538647113635 0.8548246643585206 0.9789290590434055 2.4322785913787044 1.4578902711793114 1.4844843968753068 1.0 16.16722392258412 FQEQECPPS(ph)PEPTRK ddPTM_A459_Selumetinib_30min_R1 1 FQEQECPPSPEPTRK 15 1 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 FQEQECPPS(0.834)PEPT(0.166)RK 78.08800000000002 0.017273 28199000.0 2506.7 1553.7 2240.9 1487.5 2417.7 1975.9 1902.1 2219.1 1087.3 1576.1 True False 2565.1012328108764 1371.7920817044653 1936.5980883825987 1227.7360488332145 2199.0194618796036 1956.0242399736585 1758.6230656105054 2160.2422593473266 1845.0686867500126 1778.4077875140704 1.4423582998343016 0.7713596911437344 1.0889505219101931 0.6903568784690226 1.2365102522146965 1.0998738611619934 0.9888750363991484 1.214705802861446 1.037483472409398 1.0 10.796370455606638 FQEQECPPSPEPT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 FQEQECPPSPEPTR 14 0 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 FQEQECPPS(0.029)PEPT(0.971)R 145.79 0.00054213 0.0 94734.0 57388.0 70497.0 76105.0 49596.0 44631.0 102710.0 62433.0 49685.0 52876.0 True False 89469.06353024913 61789.47506849611 65961.29977132991 65739.36771155208 43365.30708613444 50778.515130120315 107486.21851600404 62614.669693660486 59623.38831489114 51349.33249165308 1.742360790080231 1.2033160329501869 1.2845600238727939 1.2802380191064437 0.8445154977074638 0.9888836459242085 2.0932349711357223 1.2193862442873744 1.1611326851149044 1.0 15.648057902105752 FQETEFLS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 FQETEFLSPPR 11 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 FQETEFLS(1)PPR;FQETEFLS(1)PPR;FQET(0.001)EFLS(0.999)PPR;FQET(0.003)EFLS(0.997)PPR 195.72 2.0657e-05 163405000.0 8550.6 9590.0 9490.5 9865.9 9449.7 7878.700000000001 8886.099999999999 8652.599999999999 4912.700000000001 7541.4 True False 8749.812343428683 8467.19834172995 8201.74222758493 8143.00577087974 8594.976303480042 7799.447431287243 8215.814322759848 8423.104940394158 8336.493090588423 8509.412149456648 1.028251092995582 0.9950391628722094 0.9638435750357486 0.9569410469088274 1.010055236780235 0.9165671252373481 0.9654972844727533 0.989857441672043 0.9796790828988973 1.0 13.054843755191772 -4.905672972401411 2.698745004090072 0.971037587120989 1.0321164589637215 0.3243113322986395 0.02463054799642944 0.4020003800688046 4.781266088813822 0.006372162941768842 0.04918894314440138 1.2425876349085292e-05 4.905672972401411 0.06107887184273253 FQETEFLS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 4 FQETEFLSPPR 11 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 FQETEFLS(1)PPR;FQET(0.003)EFLS(0.997)PPR;FQETEFLS(1)PPR;FQETEFLS(1)PPR 154.23 0.00054657 116266500.0 93321.3 96295.9 107411.3 111574.7 115515.8 81229.6 82748.7 93954.9 89761.2 98027.6 True False 88134.87574076303 103681.48588987903 100500.57389858103 96378.0333829071 101003.67247964525 92418.24007110801 86596.67851343838 94228.29320392896 107715.94813747848 95197.2884817078 0.9258128791945391 1.0891222590841068 1.0557083662933557 1.0124031358458931 1.0609931657775435 0.9708074835436749 0.9096548850766687 0.989821188258266 1.1315022712876548 1.0 16.53863286117401 -6.765962292201231 24.991074876535368 0.9940520999838874 1.032741842852543 0.03908598426388288 0.06554452703070039 342.8307739028581 1894277.9762911608 0.023178668941932417 0.02114313024485647 1.714106129024167e-07 6.765962292201231 0.03868974286865556 FQNYS(ph)PPPTK ddPTM_A459_Selumetinib_30min_R2 1 FQNYSPPPTK 10 0 Q8TEC5-3;Q8TEC5-2;Q8TEC5 Q8TEC5-3 SH3RF2 Putative E3 ubiquitin-protein ligase SH3RF2 1 FQNYS(0.999)PPPTK 91.914 0.027362 5267400.0 32320.0 30209.0 26940.0 33664.0 30948.0 25232.0 21319.0 24603.0 21372.0 29765.0 True False 30523.783787211058 32525.933162755242 25206.709730054215 29078.905126360874 27060.035561369634 28707.478966709154 22310.37574279707 24674.5906567541 25646.99718357357 28905.60711124243 1.0559814111407908 1.1252464975940513 0.872035298654925 1.005995307915572 0.9361517804220418 0.993145684718858 0.7718355700655657 0.8536264456164031 0.887267203379324 1.0 14.819061753484608 -5.095873714386691 0.5997936216024328 0.8843577826869352 1.182207734970451 0.3765166913571878 0.07922753608226281 2.644618163825339 0.9352058332979296 0.04285577141198405 0.5173878666401326 8.019112119333558e-06 5.095873714386691 0.29784995228351574 FQPGETLTEILETPATSEQEAEHQR ddPTM_A459_Selumetinib_30min_R1 1 FQPGETLTEILETPATSEQEAEHQR 25 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 122.44 1.0822e-07 2211700.0 438.48 450.74 843.83 566.18 368.89 454.68 681.13 565.4 311.77 421.98 False True 448.6957308664428 397.9671512566592 729.242520826404 467.30729151488373 335.52396463281934 450.106332016409 629.751815719091 550.4037553219677 529.0509192201341 476.145243433277 0.9423505475579096 0.835810410258623 1.531554774270456 0.9814385378405407 0.7046672612194999 0.9453130913812922 1.3226044456061843 1.1559576891984569 1.1111124735918334 1.0 8.895257910405208 -7.2322585190769235 24.74917023636899 1.1604151941704786 0.9944033932921255 0.11347586766729989 0.21387072228801862 1472.4612122729116 1248840.5323626867 0.08672093749123212 0.06716181833568824 5.8578936246130494e-08 7.2322585190769235 -0.1660118008783531 FQPHFGQQECVS(ph)PYR ddPTM_A459_Selumetinib_30min_R1 2 FQPHFGQQECVSPYR 15 0 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7 P25054-2 APC Adenomatous polyposis coli protein 1 FQPHFGQQECVS(1)PYR;FQPHFGQQECVS(1)PYR 144.73 0.00037215 5978000.0 1443.9099999999999 1407.6 1565.1 1678.0300000000002 1714.53 1102.06 1231.82 1278.9099999999999 808.9100000000001 1300.31 True False 1477.5502936402252 1242.7975376245129 1352.5680164789176 1384.9935610242687 1559.4510642248567 1090.9742769904185 1138.9028256560282 1244.9891523148524 1372.661189551139 1467.2174545919813 1.0070424728222152 0.8470438609729616 0.9218592733106855 0.9439592997545287 1.0628629446468278 0.743566860914838 0.7762331494159779 0.8485375827682418 0.9355540211541871 1.0 10.51886699167355 -6.765746989136271 24.99999465749473 0.8460278708335539 0.9478425492537234 0.22324844211246697 0.08641942230777289 164.21579468277926 953050.2095218154 0.03029361639580555 0.0276443193889247 1.7149561140303242e-07 6.765746989136271 0.10181467842016945 FQPHFGQQECVS(ph)PYR ddPTM_A459_Selumetinib_30min_R2 2 FQPHFGQQECVSPYR 15 0 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7 P25054-2 APC Adenomatous polyposis coli protein 1 FQPHFGQQECVS(1)PYR;FQPHFGQQECVS(1)PYR 109.77 0.0024242 16605900.0 55218.0 52201.0 63973.0 71180.0 65261.0 47242.0 53381.0 55747.0 47267.0 58695.0 True False 52149.20461516773 56204.64884732986 59857.0468285359 61485.16120765117 57062.329739257606 53749.15667982222 55863.32227244483 55909.21454058736 56721.72075032627 57000.32284207537 0.914893144722213 0.9860408861726976 1.0501176808134112 1.0786809291940582 1.001087834140063 0.9429623202089432 0.9800527345646671 0.9808578575158069 0.9951122716879868 1.0 15.798682470078445 -6.534774176759702 24.89711515338859 0.9778842335448366 1.0128203302063827 0.08308003119544716 0.042490681840054535 498.63738725320724 1043639.7027467767 0.015164758684403732 0.015176572807821673 2.918944404079143e-07 6.534774176759702 0.03493609666154618 FQPPQVPDQAPAEAPTEKTEVS(ph)PVPR ddPTM_A459_Selumetinib_30min_R1 2 FQPPQVPDQAPAEAPTEKTEVSPVPR 26 1 E9PPY3;O43159 E9PPY3 RRP8 Ribosomal RNA-processing protein 8 1 FQPPQVPDQAPAEAPT(0.008)EKT(0.007)EVS(0.985)PVPR;FQPPQVPDQAPAEAPT(0.001)EKT(0.001)EVS(0.997)PVPR 131.5 3.1312e-09 31805000.0 3065.7 2531.6 8222.3 8657.7 4860.4 4582.1 3214.6 2980.0 2738.5 2193.4 True False 3137.124845186221 2235.1990950910904 7105.75682186097 7145.795220156852 4420.777678173315 4536.0082342139285 2972.1201339106933 2900.9607195957956 4647.034487873552 2474.9442555252604 1.2675537391125706 0.9031310867309662 2.871077522654306 2.8872550176449496 1.7862130301739212 1.8327718792402643 1.2008836672888685 1.1721317411975896 1.8776319820129874 1.0 11.273180315639 -7.112313928694598 3.4027549797496444 1.3281374181671093 1.9800879661742632 0.191370807924246 0.6147349143220342 0.4842546248089423 10.402218774251939 0.276374999065082 0.21064658484778784 7.721222566588755e-08 7.112313928694598 0.6519505480071539 FQPSSVLS(ph)PYER ddPTM_A459_Selumetinib_30min_R1 2 FQPSSVLSPYER 12 0 Q7Z6J9;J3QLM6 Q7Z6J9 TSEN54 tRNA-splicing endonuclease subunit Sen54 1 FQPSSVLS(1)PYER;FQPSSVLS(1)PYER 152.0 0.00050742 7332500.0 2133.3 2572.6000000000004 2415.8999999999996 2658.0 2462.3 2177.4 2266.7799999999997 2016.69 1239.9 1783.8600000000001 True False 2183.0017393207963 2271.398796030707 2087.8340495887915 2193.8301968394508 2239.585399754373 2155.497332921018 2095.7949596049525 1963.2008300676664 2104.019741286989 2012.8358072678461 1.08454039392509 1.1284570692896334 1.0372599901343893 1.089920096273168 1.1126518077966374 1.0708758882061105 1.041215061873185 0.975340771949227 1.045301228093171 1.0 10.975013776990066 -7.348572381417068 2.6004593105890517 1.0078269491274614 1.0893396781862237 0.6318366809717146 0.027743603436367118 0.183301696852237 2.4199575230848733 0.013176614052508494 0.008247602677446638 4.481543524083993e-08 7.348572381417068 0.08151272905876228 FQS(ph)LGVAFYR ddPTM_A459_Selumetinib_30min_R2 1 FQSLGVAFYR 10 0 C9IZZ0;C9J592;C9J8S3;P51149 C9IZZ0 RAB7A Ras-related protein Rab-7a 1 FQS(1)LGVAFYR 84.605 0.037636 1638200.0 6915.9 4172.7 7399.5 5677.1 5765.8 4068.3 6891.5 5334.0 4193.3 3702.6 True False 6531.541964541242 4492.732672654799 6923.424225966444 4903.869186456253 5041.448657093996 4628.671396649606 7211.968405248189 5349.52105690876 5032.077170591388 3595.6963174898783 1.8164887654085453 1.2494750045496426 1.925475238909948 1.3638162829834302 1.402078543889208 1.28728095699718 2.0057223326031037 1.4877566358671832 1.3994722374397384 1.0 11.812055464649017 -8.661758189142107 2.2998594812325854 1.0014193920273007 1.5605675041100706 0.31738615366369105 0.25235943654772053 0.6545532041747318 7.00894072814585 0.23461879259593382 0.06399950299775879 2.178922637168568e-09 8.661758189142107 0.5591481120827699 FQS(ph)MPDGFVFK ddPTM_A459_Selumetinib_30min_R2 2 FQSMPDGFVFK 11 0 P30305-3 P30305-3 CDC25B M-phase inducer phosphatase 2 1 FQS(1)MPDGFVFK;FQS(1)MPDGFVFK 131.08 0.0022707 7502200.0 45580.0 39115.0 45192.0 60432.0 51695.0 38964.0 44344.0 46472.0 40499.0 40800.0 True False 43046.8460711968 42114.99472545175 42284.39592132926 52201.05734898528 45200.61194083632 44330.93732002439 46406.08386596905 46607.225826146256 48599.931636606125 39621.99798886918 1.0864380459382625 1.062919510956588 1.067194943909896 1.3174766543486747 1.1407958769149984 1.1188465895252953 1.171220186296655 1.176296708692969 1.2265896245378407 1.0 15.274014011315353 -5.625580411798649 19.808830784789205 1.170989929720998 1.0710923784829554 0.23322011632435435 0.07600756998167946 3.4663940379106806 654.9983985651555 0.01966538385118535 0.03406145314535966 2.368206605872643e-06 5.625580411798649 -0.09989755123804267 FQSDSSSYPTVDS(ph)NSLLGQSR ddPTM_A459_Selumetinib_30min_R2 1 FQSDSSSYPTVDSNSLLGQSR 21 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 FQSDSSSYPTVDS(0.979)NS(0.021)LLGQSR 181.75 1.9799000000000002e-14 5832800.0 13891.0 16499.0 22222.0 21268.0 18150.0 12252.0 15651.0 15179.0 16753.0 18987.0 True False 13118.993830078862 17764.4202473534 20792.260713484204 18371.261710653624 15869.834736941291 13939.601787417583 16378.802511868145 15223.168376981279 20104.06811793038 18438.795975849484 0.7114886377213393 0.9634262600779704 1.127636573489788 0.9963373820457521 0.8606763021689198 0.7559930597244638 0.8882793938020981 0.8256053376218314 1.0903134968390569 1.0 14.170456832692905 -8.268388195759067 24.835565151976176 1.045156758570589 0.8993559265846354 0.21998907294400794 0.11515455744381523 962.0803138048007 3438489.9498836626 0.11125131297898465 0.0312540817645492 5.3902859437574896e-09 8.268388195759067 -0.14580083198595362 FQSDSSSYPTVDSNS(ph)LLGQSR ddPTM_A459_Selumetinib_30min_R2 1 FQSDSSSYPTVDSNSLLGQSR 21 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 FQSDSSSYPT(0.036)VDS(0.03)NS(0.93)LLGQS(0.003)R 105.95 0.00014293 5677300.0 9100.8 9236.7 13475.0 12126.0 10495.0 10548.0 9143.3 12405.0 8442.5 10152.0 True False 8595.013969388932 9945.125189328393 12608.0331704707 10474.417881483247 9176.524273509573 12000.89125478948 9568.481567105231 12441.096496241698 10131.235903159271 9858.885381936272 0.8718038232939557 1.0087474196170423 1.2788497565426102 1.062434289039892 0.9307871953073985 1.217266535705735 0.9705439506008329 1.261917145221774 1.0276248795550467 1.0 13.267208833410239 -4.922701187668224 4.417987478537627 1.0988460296767368 0.8824262558821832 0.25421168132474925 0.11608970626846504 0.2738753346860942 9.671786868842513 0.02782820051107251 0.13218576342968844 1.1948098997015495e-05 4.922701187668224 -0.21641977379455368 FQSPQIQATIS(ph)PPLQPK ddPTM_A459_Selumetinib_30min_R1 2 FQSPQIQATISPPLQPK 17 0 A0A087WYN9;Q7Z478 A0A087WYN9 DHX29 ATP-dependent RNA helicase DHX29 1 FQSPQIQAT(0.026)IS(0.974)PPLQPK;FQSPQIQAT(0.004)IS(0.996)PPLQPK 189.77 6.8837e-08 234650000.0 6428.1 7015.3 8784.0 9953.7 7992.4 6173.0 6636.9 6469.5 3748.6000000000004 5166.3 True False 6577.862223094744 6193.945414675512 7591.181047058216 8215.473149089865 7269.488831172825 6110.905224635555 6136.273289601152 6297.907844102351 6361.100413088478 5829.444929023502 1.1283856873482139 1.0625274773310311 1.3022133564146776 1.4093062459835348 1.24702933464208 1.0482825207269264 1.052634232643664 1.080361495954182 1.0912017337050364 1.0 12.50914280337614 -6.761703162866847 24.99994803704201 1.0594022086686536 1.2345796502247701 0.4854182473211337 0.09015896511397542 7.252123574873433 687265.3837230146 0.034969640871009094 0.032785050899880805 1.7309990803136366e-07 6.761703162866847 0.17517744155611648 FQSPQIQATIS(ph)PPLQPK ddPTM_A459_Selumetinib_30min_R2 2 FQSPQIQATISPPLQPK 17 0 A0A087WYN9;Q7Z478 A0A087WYN9 DHX29 ATP-dependent RNA helicase DHX29 1 FQSPQIQAT(0.003)IS(0.997)PPLQPK;FQSPQIQAT(0.001)IS(0.999)PPLQPK 215.64 1.8185e-10 178932000.0 175547.0 142241.0 202487.0 182964.0 191894.0 132724.0 144118.0 154891.0 122665.0 146037.0 True False 165790.8005103199 153150.42732309786 189459.20687117623 158043.9875694954 167786.560165874 151005.52625148656 150819.77256439926 155341.70716641453 147201.42754646536 141820.53236030607 1.1690183202042672 1.0798889608876048 1.3359081630707774 1.1143942625174497 1.1830907512009559 1.0647649091306843 1.063455129199698 1.0953400370248003 1.037941580789506 1.0 17.113706891287862 -6.773652948595866 8.208477102488285 1.0587258316077799 1.1765881471557234 0.46571847587730886 0.06631655444187985 0.14591060972882489 62.326366556692584 0.022539008735926992 0.02062278763451649 1.684019249217143e-07 6.773652948595866 0.11786231554794346 FQSQADQDQQASGLQS(ph)PPSR ddPTM_A459_Selumetinib_30min_R1 2 FQSQADQDQQASGLQSPPSR 20 0 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 FQSQADQDQQASGLQS(1)PPSR;FQSQADQDQQASGLQS(0.999)PPS(0.001)R 272.51 3.7277e-59 11163200.0 1133.45 1949.75 1677.57 1577.6 1626.31 1644.45 1721.77 1673.71 674.23 1299.57 True False 1159.8571796902252 1721.4723635858154 1449.7652082324062 1302.1017752196826 1479.2105476483505 1627.908326041136 1591.8955026950205 1629.317773823718 1144.1190661891494 1466.3824683837704 0.7909649799404695 1.1739586367826684 0.9886678540492375 0.8879687280050776 1.0087481128158324 1.110152611027461 1.0855936544642333 1.1111137844000092 0.7802323683330612 1.0 10.518045727338974 -4.732642757316901 24.681933164118433 1.019735985420093 0.790963453552037 0.2738663137288663 0.10993043656972357 4073.847389448911 3491522.716591529 0.02723015431638791 2.918279837823142 1.850790419276029e-05 4.732642757316901 -0.2287725318680559 FQSQADQDQQASGLQS(ph)PPSR ddPTM_A459_Selumetinib_30min_R2 2 FQSQADQDQQASGLQSPPSR 20 0 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 FQSQADQDQQASGLQS(1)PPSR;FQSQADQDQQASGLQS(1)PPSR 318.56 2.9758e-135 25441000.0 39559.0 29157.8 43754.4 42274.2 42143.0 30474.6 35153.4 34746.2 32290.5 33890.1 True False 37360.469147224074 31394.109502895994 40939.289540188714 36516.3810329374 36848.61957679983 34672.199529124686 36788.10275514063 34847.30568945692 38749.50227195318 32911.60475594548 1.1351761612436995 0.9538917878875125 1.243916540799884 1.1095290340207649 1.1196239092578166 1.0534946498730406 1.1177851407715043 1.0588151488772894 1.177381126180214 1.0 15.006308752927543 -10.97881173048915 9.820309232759985 0.9999995269807427 1.104879314947734 0.16247093244350108 0.07312377829237139 7.254889655746633e-07 4.01805687464753e-08 0.06737931765659431 0.016341810652770482 1.0499975108231705e-11 10.97881173048915 0.10487978796699138 FQTFS(ph)DQEGLGCPER ddPTM_A459_Selumetinib_30min_R2 1 FQTFSDQEGLGCPER 15 0 Q9P209 Q9P209 CEP72 Centrosomal protein of 72 kDa 1 FQT(0.002)FS(0.998)DQEGLGCPER 95.662 0.018252 0.0 8705.2 7546.7 8165.8 8490.1 6460.5 5957.1 7559.0 6259.6 5183.8 7199.4 True False 8221.399833676656 8125.507623534874 7640.421318250807 7333.733733760591 5648.874232397198 6777.636451830337 7910.508477874348 6277.814399667432 6220.704847473738 6991.534615712375 1.1759077635402608 1.1621922896976113 1.0928103396756645 1.0489447792018618 0.8079591309899605 0.9694061210250844 1.131440937172323 0.897916515432682 0.8897481296157329 1.0 12.771393441189794 -5.780944615026294 2.3576493111441303 0.9538881855342788 1.1599726234720495 0.5331390174414614 0.08165576878217587 0.24268577731785007 2.7520677440712165 0.025771612209205083 0.0471450225086041 1.6559811349843688e-06 5.780944615026294 0.20608443793777076 FRDQDLAS(ph)CDRDR ddPTM_A459_Selumetinib_30min_R1 1 FRDQDLASCDRDR 13 2 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 1 FRDQDLAS(1)CDRDR 91.592 0.022135 13825000.0 2112.1 2612.0 2873.5 2902.2 2762.1 2611.9 2367.6 2312.2 1410.2 2158.6 True False 2161.3078205688143 2306.1858257141453 2483.294483005667 2395.3852510411803 2512.2685426883636 2585.626657415455 2189.010025834305 2250.872944915907 2393.0064030671106 2435.6773365445565 0.8873539151269584 0.946835523372682 1.019549858163341 0.983457543863122 1.0314455469920598 1.0615637049378752 0.898727427065445 0.924126078255165 0.9824808759201322 1.0 11.250107311256377 -4.901230131419294 3.345353978571364 0.985862763582574 0.8852756960930915 0.3169798110987865 0.0454745891805156 0.36215397162131385 7.086666522812333 0.012763829461773367 0.07936110807409044 1.2553645732745962e-05 4.901230131419294 -0.10058706748948243 FRDQDLASCDR ddPTM_A459_Selumetinib_30min_R2 1 FRDQDLASCDR 11 1 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 150.46 0.0017280999999999998 5888400.0 21518.0 26306.0 19944.0 26688.0 29251.0 17919.0 17650.0 20571.0 21676.0 23253.0 False True 20322.115703378942 28323.58561287828 18660.82475338535 23053.048360632092 25576.227872742118 20387.17959751351 18470.759972811495 20630.858204287626 26011.805678043293 22581.62547145036 0.8999403399490402 1.2542757672022948 0.8263720774652815 1.0208763930558384 1.1326123491454498 0.9028216158880477 0.8179552883012706 0.9136126285670152 1.1519013859710703 1.0 14.46286171752916 -6.795874367155007 24.9989176283867 0.9431525439495854 1.027986634023918 0.056796882853035635 0.13573115433220154 503.277932901923 365363.5472240395 0.04747918151596084 0.04187450327469067 1.6000208162012024e-07 6.795874367155007 0.08483409007433274 FRDQDLASCDRDR ddPTM_A459_Selumetinib_30min_R2 1 FRDQDLASCDRDR 13 2 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 74.237 0.031434 7688200.0 14402.0 18055.0 15146.0 16717.0 17997.0 10123.0 15711.0 10712.0 12552.0 13133.0 False True 13601.59449577394 19439.76044402482 14171.522849717929 14440.115761566505 15736.055964778638 11517.351362555357 16441.592630755895 10743.17014653294 15062.750732183033 12753.816166368111 1.066472522290342 1.5242308804236637 1.1111594102389777 1.1322192176209327 1.2338311733138125 0.9030513857434045 1.289150824841938 0.8423494588908019 1.1810387209362163 1.0 13.638641370988989 -6.037285898446884 0.9265196566183885 1.0489344076312588 1.2838878636634707 0.17254406747614126 0.17009402421396683 0.9852542440339159 1.727510162018541 0.07235194177413946 0.15405701253599538 9.177282520262031e-07 6.037285898446884 0.23495345603221196 FRELAEEAAR ddPTM_A459_Selumetinib_30min_R1 2 FRELAEEAAR 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 128.51 0.008749700000000001 7738600.0 3615.1000000000004 4128.6 5382.4 5000.6 4461.9 4235.0 3784.7 3852.8999999999996 2404.3 2892.9 False True 3699.324796239914 3645.2215926659323 4651.499643406892 4127.339082887646 4058.321932812425 4192.399745072339 3499.2170319205493 3750.708576016993 4079.921496875802 3264.2318942322545 1.1332910516487658 1.1167164928162332 1.4249905625963262 1.2644135639322873 1.2432701058963644 1.284344948801007 1.071987881162335 1.149032512869052 1.2498871492815302 1.0 11.672527836081523 -7.254991685370821 24.98178135555542 1.1301462609295654 1.2477486787817758 0.27816041597360674 0.09916489006345666 778.2803129330828 3015477.445219134 0.039784724398232045 0.03011194594670802 5.5591490023778374e-08 7.254991685370821 0.11760241785221037 FRIDELEPR ddPTM_A459_Selumetinib_30min_R1 1 FRIDELEPR 9 1 F5H6X6;Q14697;Q14697-2 F5H6X6 GANAB Neutral alpha-glucosidase AB 0 109.83 0.031573000000000004 2588000.0 1792.2 1980.3 2355.6 2531.8 2244.7 2095.9 2210.7 1868.1 1121.1 1422.6 False True 1833.9547729858575 1748.445555383506 2035.7224583846014 2089.6686577720557 2041.6672813339721 2074.817148924939 2043.9451191552191 1818.5519195560096 1902.4248180956877 1605.2045672974534 1.1425053294444156 1.089235347945225 1.26820126223038 1.3018083179829554 1.271904729732581 1.292556220680416 1.2733237624637685 1.1329097590456965 1.185160357037009 1.0 10.64854145080667 -8.754233683324584 1.1122209214044172 1.002075845137311 1.2322113204794996 0.4806410259699698 0.06996237975812243 0.8163859513525954 1.932812212744507 0.07475377638922055 0.02349466179924624 1.7610282248699361e-09 8.754233683324584 0.23013547534218848 FRPDMEEEEAK ddPTM_A459_Selumetinib_30min_R2 1 FRPDMEEEEAK 11 1 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 0 128.08 0.0080158 5076000.0 33350.0 33787.0 36964.0 36341.0 42979.0 31850.0 37601.0 34297.0 29672.0 31546.0 False True 31496.540510627754 36378.35425767194 34585.77648336021 31391.293108278303 37579.59378286498 36237.04839448662 39349.52100496803 34396.79859182602 35607.22910495021 30635.185013648723 1.0281165430075019 1.1874697097949465 1.1289560179888387 1.024681035687975 1.2266808170449224 1.1828571747923877 1.284455144874655 1.1227873628476996 1.1622984842130484 1.0 14.902901943692095 -6.2745080159930735 24.899211549864134 1.1763668286357878 1.1017211125549202 0.13570315518026077 0.08238811597732751 1358.356403153909 2588025.2207590584 0.02477270474860587 0.028271818874704195 5.314861895064992e-07 6.2745080159930735 -0.07464571608086756 FRPLNESEVNR ddPTM_A459_Selumetinib_30min_R2 1 FRPLNESEVNR 11 1 P33176 P33176 KIF5B Kinesin-1 heavy chain 0 101.39 0.043164 1551100.0 5791.1 5626.9 5094.9 6860.4 7449.5 6948.5 6171.6 5341.9 4782.8 5377.3 False True 5469.2538456100865 6058.465136664817 4767.099680907689 5926.001685149896 6513.627210625023 7905.59280279718 6458.591628793395 5357.444044600845 5739.493642597597 5222.043377096724 1.0473397960648123 1.1601713542320506 0.9128801384177762 1.134805143737536 1.2473330342664397 1.5138887657406663 1.2367939448990464 1.025928675372168 1.099089614569337 1.0 12.350398726162405 -4.760743345412348 21.42813582806346 1.158259449374367 1.0473393105711397 0.03180405968165534 0.15728868580856462 12.338445666749951 377913.7136884824 0.042973807315318566 0.2482888967349352 1.734828925037008e-05 4.760743345412348 -0.11092013880322726 FRVEIS(ph)FHFEVTNHNIR ddPTM_A459_Selumetinib_30min_R2 1 FRVEISFHFEVTNHNIR 17 1 Q96BQ3;A6NCK2 Q96BQ3 TRIM43;TRIM43B Tripartite motif-containing protein 43;Tripartite motif-containing protein 43B 1 FRVEIS(1)FHFEVTNHNIR 55.815 0.042402 5372100.0 24122.0 17522.0 22663.0 19048.0 21544.0 13471.0 15221.0 21482.0 17800.0 19579.0 True False 22781.395808016856 18865.881057889954 21204.88725360872 16453.62954036722 18837.450114196323 15326.507972437337 15928.806659839323 21544.50906346346 21360.497373554637 19013.703397648766 1.1981566837123379 0.9922254840802297 1.1152423496955841 0.8653563798834621 0.990730197070696 0.806076946289833 0.8377540306960441 1.133104299193373 1.1234264533755205 1.0 14.214751940102929 FS(ph)CDIEQLK ddPTM_A459_Selumetinib_30min_R1 1 FSCDIEQLK 9 0 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3 B8ZZZ7 SPATS2L SPATS2-like protein 1 FS(1)CDIEQLK 140.78 0.0022636 3594600.0 1187.8 1471.9 1506.3 1290.3 1233.3 1283.0 933.1 1211.8 757.06 1027.4 True False 1215.4734289435348 1299.569263732255 1301.7527335136378 1064.9733269307544 1121.7482327567996 1270.0941848707937 862.7155157568801 1179.659127518854 1284.6755265253064 1159.276797723468 1.0484755938619863 1.1210172292624907 1.1229007050515953 0.9186531888002053 0.9676276062452339 1.095591827046779 0.7441842340423265 1.0175819354233706 1.1081697908972994 1.0 10.179009360950467 -5.7522571001545835 24.998192060811782 0.9741838044923025 1.0998198097959422 0.23647630957484833 0.09740983939288717 279.6372153746493 761287.1904417145 0.0268045882137888 0.045606895331845566 1.7690613728073916e-06 5.7522571001545835 0.12563600530363972 FS(ph)CDIEQLK ddPTM_A459_Selumetinib_30min_R2 1 FSCDIEQLK 9 0 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3 B8ZZZ7 SPATS2L SPATS2-like protein 1 FS(1)CDIEQLK 111.63 0.010162 1372500.0 15514.0 13903.0 16144.0 18247.0 17357.0 14352.0 13789.0 16939.0 14154.0 14010.0 True False 14651.793987462628 14969.315394809038 15105.31261625818 15761.72712216929 15176.458486451233 16328.857725515598 14430.215822385155 16988.289685597596 16985.195495802942 13605.494897648465 1.0769026851051926 1.1002404181119712 1.1102361751551528 1.1584824543863892 1.1154653763513072 1.200166392208036 1.060616753079613 1.2486344534614322 1.2484070313927804 1.0 13.731901814887314 -5.3228843398705905 0.7643631174429197 1.1608155894004932 1.0594906792062075 0.0837396434957105 0.07402998085646807 3.2223831080939846 2.3735599904879776 0.03183323559334522 0.24597309373218312 4.7546183278998805e-06 5.3228843398705905 -0.10132491019428569 FS(ph)DSEGEETVPEPR ddPTM_A459_Selumetinib_30min_R2 1 FSDSEGEETVPEPR 14 0 A0A1B0GWH8;H3BQ48;A0A1B0GWD3;A0A1B0GV71;A0A1B0GW34;A0A0D9SFH9;H3BPL0;Q9UBD8;A0A1B0GV41;H3BR84;O95090;H3BR00;Q9UP10;Q9UBH5;A0A0D9SF04;Q13286-5;Q13286-4;Q13286-6;Q13286-2;Q13286-7;Q13286-3;Q13286 A0A1B0GWH8 CLN3 Battenin 1 FS(0.829)DS(0.17)EGEETVPEPR 188.63 9.3604e-05 6141000.0 14674.0 2480.4 8791.1 11941.0 8711.5 6602.9 14025.0 12370.0 10366.0 6001.2 True False 13858.477824676198 2670.638704256948 8225.490197025969 10314.61520062605 7617.08348820187 7512.389539841624 14677.190290010269 12405.99465203626 12439.48965023974 5827.929763009844 2.37794180579125 0.4582482653115731 1.411391442847091 1.769859215890593 1.3069964460704164 1.2890322713775877 2.518422645236241 2.1287138240370904 2.134461147626348 1.0 12.508767775110499 -7.238310727156448 24.645425119172387 2.039458948956854 1.3994046678391683 0.14852513988225513 0.5769129165388626 978.1263955853741 1042273.0027018768 0.20997383595168206 0.1625292251620079 5.776825816508732e-08 7.238310727156448 -0.6400542811176859 FS(ph)GGFGAR ddPTM_A459_Selumetinib_30min_R1 4 FSGGFGAR 8 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;O15523;O15523-2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 FS(1)GGFGAR;FS(1)GGFGAR;FS(1)GGFGAR;FS(1)GGFGAR 92.051 0.026006 151083000.0 12381.3 13772.8 11467.4 11805.300000000001 10867.7 11285.400000000001 12108.900000000001 10689.099999999999 6116.1 9715.7 True False 12669.760200184019 12160.274173198988 9910.190065919323 9743.72596792655 9884.718453848276 11171.879122323351 11195.515924068686 10405.590344909873 10378.574997729937 10962.804733932144 1.1557042661690848 1.1092302078099074 0.9039830870329414 0.8887986427202983 0.9016596294243052 1.019071249873135 1.0212273406107704 0.9491722782129306 0.9467080048964207 1.0 13.42032932548261 -5.155218057918336 4.899881525276113 0.9528548348315157 1.1434282442274597 0.7115257769528767 0.04575677460361166 0.12602068884470277 4.623803008151679 0.013183540782788356 0.03761909128002908 6.994906956978526e-06 5.155218057918336 0.19057340939594403 FS(ph)GGFGAR ddPTM_A459_Selumetinib_30min_R2 2 FSGGFGAR 8 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;O15523;O15523-2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 FS(1)GGFGAR;FS(1)GGFGAR 89.029 0.030241000000000007 64976800.0 37104.0 38001.0 43768.0 46062.0 49576.0 41810.0 49118.0 46988.0 38099.0 46242.0 True False 35041.90821908043 40915.55450752632 40952.01453099528 39788.27613861796 43347.81966493668 47568.94798660867 51402.08432547057 47124.727300717845 45719.864575003274 44906.87330885511 0.7803239378986241 0.9111200912635852 0.9119319942259267 0.8860175115057984 0.9652825162599107 1.0592798937357464 1.1446373469812399 1.0493878515346424 1.018103938356088 1.0 15.454648655912262 -6.50785164728051 2.2444891810654255 1.063772320796417 0.8756441960103919 0.7465805256870395 0.049786130706990506 0.15763625536063872 1.591056737175617 0.018369745608665118 0.019965363270052605 3.1056202705684887e-07 6.50785164728051 -0.18812812478602503 FS(ph)PDSQYIDNR ddPTM_A459_Selumetinib_30min_R1 2 FSPDSQYIDNR 11 0 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 FS(0.998)PDS(0.002)QYIDNR;FS(1)PDSQYIDNR 199.96 1.9225e-05 75005000.0 4174.9 6199.2 4000.3 3587.8 4356.3 4436.799999999999 5609.799999999999 5347.5 2784.4 4928.9 True False 4272.167047058734 5473.394782070108 3457.0812320750197 2961.2580813470963 3962.273434167234 4392.1698202920825 5186.648269524106 5205.666928871986 4724.9234354701875 5561.572326551683 0.7681581387807982 0.984145213025352 0.6216014157669867 0.5324498015084076 0.712437634812518 0.7897352695250015 0.9325866796269753 0.9360063347588672 0.8495661223199018 1.0 12.441277093337067 -7.112486717814342 3.139659819483852 0.9248396778635062 0.7230842980514706 0.4224675241027559 0.11349418398707106 0.3018855829528122 5.642563473761701 0.05191387689954939 0.03933416972322331 7.718151199258097e-08 7.112486717814342 -0.20175537981203562 FS(ph)PDSQYIDNR ddPTM_A459_Selumetinib_30min_R2 5 FSPDSQYIDNR 11 0 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 FS(1)PDSQYIDNR;FS(1)PDSQYIDNR;FS(1)PDSQYIDNR;FS(0.999)PDSQY(0.001)IDNR;FS(0.997)PDS(0.003)QYIDNR 209.11 1.8421e-05 139857300.0 153568.0 137811.0 179286.0 185830.0 183326.0 158054.0 165015.0 190766.0 159385.0 144205.0 True False 145033.3053414117 148380.66056779292 167750.9339518377 160519.63342536945 160294.94892476554 179824.50382864007 172688.52447101907 191321.09747698877 191266.45358898878 140041.42696041407 1.0356457263350274 1.0595483335780072 1.1978664998840405 1.1462296329695643 1.1446252184368029 1.2840807733233939 1.2331245704875133 1.3661750071360674 1.3657848091126252 1.0 17.095494141817326 -5.592362709620611 0.6699120689117177 1.26951585170263 1.001602897680737 0.30189740006290045 0.1034097244913639 1.5171395239776655 1.0170955996326358 0.0540025112258203 0.2686025305286764 2.5564499253998465e-06 5.592362709620611 -0.26791295402189297 FS(ph)PEVPGQK ddPTM_A459_Selumetinib_30min_R2 1 FSPEVPGQK 9 0 P46821;D6RA32;D6RGJ3 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 FS(1)PEVPGQK 84.68700000000003 0.036166 6508900.0 97868.0 84593.0 81862.0 87115.0 96265.0 68267.0 82523.0 83887.0 66273.0 90238.0 True False 92428.88835664526 91081.01109063353 76595.08804460635 75249.7867182428 84171.33007998094 77670.15958387498 86360.48301622237 84131.09728175949 79529.45182233637 87632.59447351898 1.0547318484856183 1.0393508447151658 0.8740479327900309 0.8586963237860309 0.9605025457213414 0.8863158742532212 0.985483581024398 0.9600434380290135 0.9075327770464306 1.0 16.41917995187682 -5.192602512144427 7.62010508154224 0.9268222793696964 1.0485453170897607 0.5193901016011817 0.04536248060095877 0.23208547504658203 22.850796207635348 0.011718847663201698 0.03135584278846284 6.417967120473944e-06 5.192602512144427 0.12172303772006432 FS(ph)PGAPGGSGSQPNQK ddPTM_A459_Selumetinib_30min_R1 1 FSPGAPGGSGSQPNQK 16 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 FS(1)PGAPGGSGSQPNQK 182.7 9.0591e-07 11725000.0 3887.6 5514.5 2957.3 3361.3 3386.9 3194.3 4067.1 4041.0 2084.8 3957.4 True False 3978.173516047218 4868.859776378499 2555.714903286118 2774.312054415517 3080.5554930057615 3162.1682421923438 3760.315372559007 3933.8195529820864 3537.75333223253 4465.370838340324 0.8908943198826941 1.0903595586224912 0.5723410206700814 0.6212948834159238 0.689876743619066 0.7081535569322726 0.8421059546213703 0.8809614465176642 0.7922641725199764 1.0 12.12456427734754 -8.777299574167069 0.796543033098674 0.9962716702741248 0.7679870525361865 0.17265963021684916 0.14222862344032028 1.973548441412816 2.4907700007337352 0.1549693488993942 0.054655928218527654 1.6699383018168571e-09 8.777299574167069 -0.2282846177379383 FS(ph)PGAPGGSGSQPNQK ddPTM_A459_Selumetinib_30min_R2 5 FSPGAPGGSGSQPNQK 16 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 FS(1)PGAPGGSGSQPNQK;FS(1)PGAPGGSGSQPNQK;FS(1)PGAPGGSGSQPNQK;FS(1)PGAPGGSGSQPNQK;FS(1)PGAPGGSGSQPNQK 265.77 5.4949e-40 284347000.0 167296.0 149509.0 161273.0 182400.0 180781.0 167192.0 209112.0 212408.0 172412.0 164074.0 True False 157998.35805894985 160975.85955279434 150896.8707607662 157556.80534244984 158069.67457735425 190221.1803821353 218836.12234756717 213026.07211396244 206899.21759378148 159336.7573045519 0.991600185241351 1.0102870315423171 0.9470311390380945 0.9888289934337002 0.9920477688348095 1.193831125975231 1.3734189527234437 1.3369549858906082 1.2985027503623663 1.0 17.281719594180394 -6.852656227624539 3.497168461557985 1.2809669656993548 0.9835177305805546 0.6317171415145035 0.0968262616909279 0.1339789061938384 3.2129383461262724 0.03390279783672624 0.030044625163073404 1.4039245625986398e-07 6.852656227624539 -0.29744923511880017 FS(ph)PPEPGDTPTDEPDALYVACQGQPK ddPTM_A459_Selumetinib_30min_R1 2 FSPPEPGDTPTDEPDALYVACQGQPK 26 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 FS(0.998)PPEPGDT(0.001)PT(0.001)DEPDALYVACQGQPK;FS(1)PPEPGDTPTDEPDALYVACQGQPK 108.5 1.7397e-08 6320000.0 4038.96 5101.099999999999 3875.61 4000.7200000000003 4252.91 3830.79 5027.099999999999 4637.04 2467.58 4235.71 True False 4133.0599095519265 4503.860840562946 3349.323449201877 3302.0693548154763 3868.235041412247 3792.255730679026 4647.90179965857 4514.050635971304 4187.303035087463 4779.404637809295 0.8647645936600108 0.9423476733761867 0.7007825666623374 0.690895541401371 0.8093550001628037 0.7934577668270535 0.9724855189890342 0.9444796952869803 0.8761139414650546 1.0 12.222615200028088 -7.255408578521459 24.557148369730434 0.9436430993317437 0.7976450024266307 0.48835712722494884 0.07412503881703483 373.335972622176 1520211.3567357655 0.03157351968021778 0.023803347490043782 5.553815158086603e-08 7.255408578521459 -0.145998096905113 FS(ph)PPPVGGQGK ddPTM_A459_Selumetinib_30min_R2 3 FSPPPVGGQGK 11 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 FS(1)PPPVGGQGK;FS(1)PPPVGGQGK;FS(1)PPPVGGQGK 117.03 0.0057169 29496100.0 285426.0 206766.0 250035.0 268586.0 270772.0 198625.0 279642.0 289959.0 244297.0 201454.0 True False 269563.1655708079 222624.28734252244 233948.02031752444 232004.1234633063 236755.20062760703 225983.79081177074 292645.9071001105 290802.7326847038 293163.2262284992 195637.49957964843 1.3778706339530917 1.1379428167956476 1.1958240154376893 1.1858877973895399 1.2101729021087733 1.1551149002482914 1.495857939959858 1.4864365641021262 1.4985022138311774 1.0 17.577823405423814 -7.255467692880946 24.932888794268635 1.4107355616938806 1.2053757565659253 0.19382202562047923 0.15056727099072162 569.7081125158903 2378641.531800765 0.054988814435377606 0.0414666498823586 5.553059247301734e-08 7.255467692880946 -0.20535980512795526 FS(ph)PPSPLPQAVFSTSSR ddPTM_A459_Selumetinib_30min_R1 1 FSPPSPLPQAVFSTSSR 17 0 A0A1X7SBS4;Q99594 A0A1X7SBS4 TEAD3 Transcriptional enhancer factor TEF-5 1 FS(0.603)PPS(0.397)PLPQAVFSTSSR 92.952 0.0076027 11523000.0 552.54 563.27 696.4 843.61 777.06 640.34 578.03 588.36 378.57 466.08 True False 565.4131069443173 497.3220865428811 601.8327050513822 696.2893500209672 706.7750602010854 633.8987609822017 534.4287317253772 572.7547815373769 642.4056403411687 525.9059080036536 1.0751221812484169 0.9456484115775061 1.1443733487154533 1.3239808479507134 1.3439192247982412 1.2053463392120665 1.0162059858845784 1.0890822347129778 1.2215220071965909 1.0 9.038660893856493 -10.70546922899296 14.472511819810526 1.0000000669218665 1.1518870039072158 0.12494011526914783 0.1204313193882214 0.0 0.0 0.13175147482392469 0.03195442629587927 1.9702928031556046e-11 10.70546922899296 0.15188693698534927 FS(ph)PTMGR ddPTM_A459_Selumetinib_30min_R1 1 FSPTMGR 7 0 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 FS(0.643)PT(0.357)MGR 98.582 0.021764 116220000.0 7364.3 13432.0 6731.5 7039.9 8231.7 7569.5 9798.8 9547.5 4520.3 8869.4 True False 7535.87386156665 11859.375195632609 5817.39927348274 5810.513620289709 7487.144188424671 7493.357702556104 9059.668626940856 9294.269285349284 7670.618950350491 10007.873885272058 0.7529944869366019 1.1850044606462602 0.5812822323874235 0.5805942088099918 0.7481253535221919 0.748746216075284 0.9052540760204209 0.9286956842079176 0.7664583944886482 1.0 13.288847894085986 -7.26370972496057 23.17688670916163 0.8941600254980392 0.767511230170124 0.13558324602164074 0.16543400093951208 180.92236427860885 1846912.983475174 0.0708120097936378 0.05040409778686196 5.4486671079893346e-08 7.26370972496057 -0.12664879532791518 FS(ph)PTMGR ddPTM_A459_Selumetinib_30min_R2 5 FSPTMGR 7 0 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 FS(0.645)PT(0.355)MGR;FS(0.63)PT(0.37)MGR;FS(0.949)PT(0.051)MGR;FS(0.621)PT(0.379)MGR;FS(0.963)PT(0.037)MGR 120.87 0.0091095 447831700.0 656538.0 447877.0 601739.0 554537.0 653810.0 577181.0 691730.0 674329.0 591436.0 536810.0 True False 620050.2462898513 482227.7257484635 563023.7678638869 479008.1039703172 571672.5426644405 656682.4436225495 723896.8156369922 676291.1857488239 709739.7261025639 521310.90050011803 1.1894058721868428 0.9250290475143331 1.0800153369587164 0.9188530366635002 1.096605772325129 1.2596752590298097 1.3886086305552483 1.297289554275627 1.3614519194240466 1.0 18.99178450113277 -6.702983160346109 3.454754908024287 1.2909366956754664 1.023265798388807 0.4417165579446335 0.12304340198434975 0.18626310660817189 4.504888942665496 0.040687429865733434 0.039283276841212494 1.9816038604820522e-07 6.702983160346109 -0.2676708972866595 FS(ph)PVLGR ddPTM_A459_Selumetinib_30min_R1 1 FSPVLGR 7 0 F8VZ44;Q9NRG9-2;Q9NRG9 F8VZ44 AAAS Aladin 1 FS(1)PVLGR 80.219 0.0453 38559000.0 5260.0 5827.1 5107.3 6312.1 4931.2 4936.9 5897.8 5718.1 2430.8 4606.4 True False 5382.547765821676 5144.860423054702 4413.756712390756 5209.810227791686 4485.17383067407 4887.239268346552 5452.92419765398 5566.437412993531 4124.890061392379 5197.676310135661 1.0355680970986032 0.9898385578613338 0.8491788347388557 1.002334488900812 0.8629190359406982 0.9402738794673026 1.0491080768189769 1.0709473004578551 0.7936027207674881 1.0 12.34365107616694 FS(ph)PVLGR ddPTM_A459_Selumetinib_30min_R2 4 FSPVLGR 7 0 F8VZ44;Q9NRG9-2;Q9NRG9 F8VZ44 AAAS Aladin 1 FS(1)PVLGR;FS(1)PVLGR;FS(1)PVLGR;FS(1)PVLGR 90.601 0.029436 183310800.0 273568.0 192771.0 255884.0 283249.0 265152.0 213203.0 214541.0 234659.0 194907.0 216123.0 True False 258364.1857394727 207555.91584354005 239420.70202543432 244669.9975682205 231841.23527104425 242569.7779858627 224517.58160492653 235341.8188401113 233893.84615659624 209882.96743500943 1.230991675489225 0.988912622973134 1.1407343099414262 1.1657448937298018 1.1046214855087477 1.155738271429647 1.069727497894505 1.1213002261033174 1.1144012733144808 1.0 17.679225567250334 -14.416791160357574 0.3135104414174406 0.002023446158876466 1.123653310517766 0.2750752506743881 0.059804334142258 382.2943665227105 3.6700979679989 251.56945771145556 0.05248561050497839 3.830088769208524e-15 14.416791160357574 1.1216298643588896 FS(ph)PVTPK ddPTM_A459_Selumetinib_30min_R1 1 FSPVTPK 7 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 FS(1)PVTPK 87.696 0.033251 191110000.0 6077.1 8040.1 6140.2 5654.7 6520.5 6034.7 6267.9 6453.3 3869.7 6814.8 True False 6218.684606021849 7098.761354258914 5306.39456570433 4667.212796865327 5930.721926287777 5973.996397069196 5795.107256684761 6282.137520727364 6566.598268294425 7689.5459617732995 0.8087193492225055 0.9231704172845411 0.690079049151117 0.6069555757995642 0.7712707558769937 0.7768984575640046 0.7536345169784694 0.8169711907513756 0.853964369409932 1.0 12.908682699749525 -8.618857169896595 1.0840431532353667 0.9991292812327117 0.7587074046203982 0.47459236150064665 0.07647235340949789 0.6149402658270272 1.5407126916288851 0.08029903001271561 0.02572449110390723 2.4051536732020006e-09 8.618857169896595 -0.2404218766123135 FS(ph)PVTPK ddPTM_A459_Selumetinib_30min_R2 4 FSPVTPK 7 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 FS(1)PVTPK;FS(0.982)PVT(0.018)PK;FS(1)PVTPK;FS(1)PVTPK 112.11 0.014704 569710000.0 3278080.0 2963350.0 3335150.0 3479450.0 3248720.0 2905220.0 3325250.0 3257210.0 2775590.0 3159950.0 True False 3095897.436793959 3190629.416327942 3120570.080036759 3005542.9076139634 2840586.7496747035 3305387.684038634 3479880.713857869 3266687.9418398584 3330785.5564643075 3068714.0329639083 1.0088582394899128 1.0397284928000547 1.016898298934282 0.9794144632991654 0.9256602991224735 1.077124700618042 1.133986639509983 1.0645136388563186 1.0854010900609328 1.0 21.54920277966191 -6.876079214201002 11.384876882249547 1.0804907120841882 0.9971294044554893 0.4609639986211559 0.041696348387120094 0.3412427332287199 32.55583666319211 0.015020816143372872 0.013248725351557949 1.3302117686303532e-07 6.876079214201002 -0.08336130762869898 FS(ph)SPTEELDYR ddPTM_A459_Selumetinib_30min_R1 1 FSSPTEELDYR 11 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 FS(0.738)S(0.255)PT(0.007)EELDYR 129.0 0.0026686 24806000.0 2555.3 2518.8 2813.7 3256.1 2792.9 2503.2 3133.9 2634.1 1241.6 2217.4 True False 2614.833518251737 2223.897725041649 2431.614994547779 2687.4832595669436 2540.2826881265437 2478.020080723752 2897.5073998826347 2564.2351112373426 2106.9045171239 2502.024889305057 1.0450869331591712 0.8888391696452475 0.9718588351945474 1.0741233115044664 1.015290734710522 0.9904058474062692 1.1580649785971648 1.0248639500742796 0.8420797595299291 1.0 11.288880425683956 -4.424871394215724 22.34389727693975 1.0019151019361776 7.73018816053528 0.025953709630101796 0.08347177941163779 3369.5917320378476 766162.5557744771 0.020726617206639188 3085.468983340712 3.759487159063877e-05 4.424871394215724 6.728273058599102 FS(ph)SPTEELDYR ddPTM_A459_Selumetinib_30min_R2 1 FSSPTEELDYR 11 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 FS(0.942)S(0.058)PTEELDYR 228.93 3.9425e-07 48519000.0 98864.0 90392.0 124890.0 134980.0 127370.0 98903.0 104900.0 108750.0 82290.0 116430.0 True False 93369.53466394912 97324.77574390988 116854.7133699507 116595.49114651208 111368.64189775262 112525.99049795647 109778.05785540669 109066.44449546831 98750.29937470841 113068.36337853008 0.8257794830846428 0.8607604535504433 1.0334872627345342 1.0311946477563656 0.9849673115450771 0.9952031420251671 0.9708998571765993 0.9646062013857568 0.8733680794875603 1.0 16.786835792963096 -5.142151336256479 5.255928555658299 0.9821459733284703 0.834847117503884 0.6321802087739428 0.042489913567145154 0.14139958400466465 5.4186585808903756 0.011526902363975309 0.03248802471661137 7.20856242523782e-06 5.142151336256479 -0.14729885582458635 FS(ph)SVSHSGESSFTYR ddPTM_A459_Selumetinib_30min_R1 1 FSSVSHSGESSFTYR 15 0 F8VXG7 F8VXG7 SCAF11 1 FS(0.862)S(0.138)VSHSGESSFTYR 79.88600000000002 0.03023 10567000.0 3016.4 3427.2 3452.7 2916.5 778.99 3100.2 1577.8 1523.6 2233.3 1441.4 True False 3086.6762511073216 3025.941830737945 2983.842304323531 2407.1880244854265 708.5304920418552 3069.0148027563796 1458.785275705933 1483.189178649716 3789.746986221657 1626.4177304249627 1.8978373104066024 1.8604948618872374 1.8346100442128668 1.4800552031958347 0.4356386915781624 1.8869782008306588 0.8969314883973691 0.9119361839852651 2.3301190803124383 1.0 10.667482132611537 -5.878003591568051 4.2398038315737185 1.2322352607678098 1.8632246811686364 0.22939043214010246 0.5050584031106893 0.3143893949206947 10.040844752762037 0.14082523136100994 0.21683859229921068 1.3243305830797355e-06 5.878003591568051 0.6309894204008266 FSAS(ph)SGGGGSR ddPTM_A459_Selumetinib_30min_R2 5 FSASSGGGGSR 11 0 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5;H0YD77;H0YD99;H0YEN8;H0YDC0;H0YCF8;H0YEC5 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 FS(0.005)AS(0.497)S(0.497)GGGGSR;FS(0.001)AS(0.5)S(0.5)GGGGSR;FS(0.002)AS(0.499)S(0.499)GGGGSR;FS(0.001)AS(0.499)S(0.499)GGGGSR;FS(0.001)AS(0.5)S(0.5)GGGGSR 123.26 0.003915 104979500.0 246277.0 231472.0 252668.0 290602.0 304557.0 214127.0 230917.0 231668.0 206744.0 247992.0 True False 232589.91026494367 249225.1581002107 236411.61596411833 251021.50628358862 266295.8268858749 243621.05059862568 241655.09805335518 232342.11552529794 248098.5769100106 240831.826599403 0.9657772959212371 1.0348514215057176 0.9816460693850186 1.0423103533617881 1.1057335346661987 1.0115816253964733 1.003418449569465 0.964748383990681 1.0301735464669088 1.0 17.87766653531775 -10.404571890122241 13.725652273169661 0.9999999552232675 1.016617996358652 0.013034513572268036 0.03976901980170222 0.0 0.0 0.04030623632340947 0.009775698219560265 3.939382124243654e-11 10.404571890122241 0.016618041135384454 FSASGELGNGNIK ddPTM_A459_Selumetinib_30min_R2 1 FSASGELGNGNIK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 150.09 0.0040042 0.0 9416.3 7152.9 9155.1 10796.0 11202.0 8095.4 8747.7 9031.3 7847.3 9135.4 False True 8892.979742435504 7701.504429801447 8566.070833319205 9325.566175861217 9794.704612849382 9210.467867275574 9154.485383238709 9057.5795877878 9416.979271881759 8871.637265380281 1.0024056976651319 0.8681040713707904 0.9655569290176589 1.0511663063876946 1.1040470118262364 1.0381925671394963 1.0318822906525027 1.020959189025133 1.0614702777163312 1.0 13.114984663897589 -5.656556473361495 4.222220643562248 1.0465738284540522 0.931535784949594 0.56706511321752 0.03983786357218891 0.13871644624846563 4.412651734244619 0.01073156686733175 0.01920136878292007 2.205177368125896e-06 5.656556473361495 -0.11503804350445823 FSCPPNFTAKPPAS(ph)ESPR ddPTM_A459_Selumetinib_30min_R1 1 FSCPPNFTAKPPASESPR 18 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 FSCPPNFTAKPPAS(0.872)ES(0.128)PR 162.81 1.5402999999999998e-05 0.0 456.33 645.32 520.47 619.37 515.94 544.61 612.07 411.93 276.05 359.02 True False 466.96160113638933 569.7656343988712 449.79303273706614 511.2086565148423 469.2733180966053 539.1317178663161 565.9010671196163 401.00427826278377 468.43668810571245 405.1037141509431 1.1526964202613994 1.4064685523632954 1.110315746375684 1.261920438291425 1.1584029020325208 1.3308486173627962 1.396928853900262 0.989880527516882 1.1563376778401278 1.0 8.66214750205798 -7.774567749430957 24.999401106315258 1.0548317946481123 1.2584885044068204 0.4657851118298638 0.10344301585663587 216.1492674196581 411591.092017232 0.054527407744629976 0.026442139749260973 1.680475753009009e-08 7.774567749430957 0.2036567097587081 FSCPPNFTAKPPASES(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 FSCPPNFTAKPPASESPR 18 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 FSCPPNFT(0.018)AKPPAS(0.201)ES(0.781)PR 71.946 0.011413 36201000.0 1178.1 1791.4 1750.4 2312.0 1746.0 1437.3 1472.9 1205.2 715.27 1033.6 True False 1205.5474378164495 1581.6620552007334 1512.705294258959 1908.2526016150525 1588.0746082813378 1422.8420669639854 1361.7979671614073 1173.2341809586753 1213.7609487461432 1166.2726281165812 1.03367549640884 1.3561683752751417 1.2970426106131234 1.6361977085037982 1.3616667063908774 1.2199909632293602 1.1676497710150162 1.0059690613277414 1.0407180272302634 1.0 10.187689357297431 -7.340594726873397 1.6658585439772644 1.0154880043865218 1.3476419007290832 0.49283478973539485 0.13899279649913493 0.33540130741407365 1.8097537823292034 0.0847465341329504 0.04836685789194911 4.564626772166589e-08 7.340594726873397 0.3321538963425614 FSCPPNFTAKPPASES(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 FSCPPNFTAKPPASESPR 18 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 FSCPPNFTAKPPAS(0.049)ES(0.951)PR;FSCPPNFTAKPPAS(0.122)ES(0.878)PR 114.78 0.00059239 49368000.0 83750.0 68565.0 67013.0 90393.0 85954.0 65622.0 69163.0 59429.0 60949.0 74287.0 True False 79095.51027781324 73823.71502877663 62701.4565382376 78081.31746337749 75155.69008149038 74660.83484279433 72379.21654388448 59601.9285509994 73140.50305734739 72142.14128919426 1.0963842889102113 1.0233091742154075 0.8691377247438216 1.0823260311940979 1.041772377953349 1.0349129303426612 1.0032862242574678 0.8261735441435645 1.013838815293145 1.0 16.13855462470785 -7.546587614472742 24.97842956682438 0.934949651745762 1.0207613652654137 0.17397530084456458 0.07445419621092829 362.6559660274737 382070.75175151177 0.03463811056050555 0.019999509445561756 2.8406150621198738e-08 7.546587614472742 0.08581171351965178 FSDS(ph)EGEETVPEPR ddPTM_A459_Selumetinib_30min_R2 1 FSDSEGEETVPEPR 14 0 A0A1B0GWH8;H3BQ48;A0A1B0GWD3;A0A1B0GV71;A0A1B0GW34;A0A0D9SFH9;H3BPL0;Q9UBD8;A0A1B0GV41;H3BR84;O95090;H3BR00;Q9UP10;Q9UBH5;A0A0D9SF04;Q13286-5;Q13286-4;Q13286-6;Q13286-2;Q13286-7;Q13286-3;Q13286 A0A1B0GWH8 CLN3 Battenin 1 FS(0.485)DS(0.512)EGEET(0.003)VPEPR 185.2 7.9051e-05 4654900.0 9102.3 3942.1 7804.2 7668.2 4914.0 4833.4 9394.7 7094.9 5764.7 4824.3 True False 8596.43060539391 4244.446394150665 7302.086268570491 6623.777931617175 4296.6593882826155 5499.156976763314 9831.572165244886 7115.54498437608 6917.801079175866 4685.009923963274 1.8348799137914695 0.9059631597450459 1.5586063609430536 1.4138236714798258 0.9171078520678706 1.1737770177680464 2.0985168280983895 1.5187897357444018 1.476581947840095 1.0 12.193836388520388 FSEGVLQS(ph)PSQDQEK ddPTM_A459_Selumetinib_30min_R1 3 FSEGVLQSPSQDQEK 15 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 FSEGVLQS(0.999)PS(0.001)QDQEK;FS(0.013)EGVLQS(0.96)PS(0.027)QDQEK;FS(0.025)EGVLQS(0.965)PS(0.01)QDQEK 204.9 4.9505e-06 53466000.0 11864.8 14459.2 15575.7 15400.7 13428.699999999999 12903.300000000001 12810.1 11913.599999999999 7889.9 11826.9 True False 12141.226755118067 12766.31014210029 13460.605491195885 12711.256851943324 12214.076456029547 12773.504517259013 11843.823843529317 11597.612627173317 13388.58404450376 13344.997818761598 0.9097960838966072 0.9566363603411208 1.0086629967276395 0.9525109726187213 0.9152550357751201 0.9571754668480253 0.8875103618884227 0.8690606611316452 1.0032661096190576 1.0 13.704011449221005 -6.015561436676231 23.278882638309984 0.9308325106136709 0.9619247065276781 0.018608643303693717 0.04646479802029268 751.0830602499062 1123577.1095702986 0.013500337147470285 0.018046814322679516 9.64802818081639e-07 6.015561436676231 0.031092195914007248 FSEGVLQS(ph)PSQDQEK ddPTM_A459_Selumetinib_30min_R2 4 FSEGVLQSPSQDQEK 15 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 FS(0.113)EGVLQS(0.809)PS(0.078)QDQEK;FSEGVLQS(0.997)PS(0.003)QDQEK;FSEGVLQS(0.988)PS(0.012)QDQEK;FSEGVLQS(0.969)PS(0.031)QDQEK 205.12 4.2748e-06 72726500.0 378523.0 380299.0 413679.0 438555.0 463450.0 354180.0 393404.0 382227.0 296920.0 447210.0 True False 357486.20700762625 409466.710445981 387063.343519639 378823.05245042697 405227.26770443143 402965.0800740749 411698.06551523675 383339.2172889137 356312.29663796944 434297.88530887687 0.8231359605939103 0.9428245549820357 0.891239300519172 0.8722654778321206 0.9330629538208086 0.9278541151253413 0.9479623996382877 0.8826642501753816 0.8204329532586987 1.0 18.728325402448917 -4.747273980926332 24.736861633393534 0.9096864513135613 0.8231357087510731 0.24587736648344882 0.046939599700796475 992.8660955682105 1733716.6794824528 0.011455184057084492 0.23573117767647406 1.7894765807999874e-05 4.747273980926332 -0.08655074256248818 FSFYGNLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 FSFYGNLSPR 10 0 Q9P2F8;Q9P2F8-2 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 FSFYGNLS(1)PR 103.21 0.011565 0.0 3269.7 2513.3 3310.3 3957.9 2827.6 2814.7 2596.7 2843.6 1712.5 2136.3 True False 3345.8776482713224 2219.0416675985302 2860.7794421763215 3266.727063984523 2571.8440792533274 2786.386673543122 2400.8288283848365 2768.178490685436 2905.987423948677 2410.514914324161 1.388034410568835 0.9205674913738029 1.186791844836356 1.355198860032948 1.0669272627066066 1.1559300699553416 0.9959817357354787 1.1483764212517031 1.205546336461242 1.0 11.235125640658412 FSFYGNLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 FSFYGNLSPR 10 0 Q9P2F8;Q9P2F8-2 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 FSFYGNLS(1)PR;FSFYGNLS(1)PR 139.76 0.0014922000000000002 7752100.0 51879.0 37807.0 55688.0 64281.0 44657.0 38435.0 40341.0 37413.0 33198.0 49597.0 True False 48995.772868091655 40706.67533133463 52105.09470850999 55525.81690908994 39046.788421354664 43729.07237180825 42216.93643417499 37521.865635944414 39838.527629621756 48165.00574151827 1.017248355186165 0.845150430372428 1.0818039758603282 1.1528248788565314 0.8106879220756805 0.9079013216874542 0.8765064134059464 0.779027533751554 0.8271259811203743 1.0 15.555697717311023 -6.284015551525989 24.900365100716897 0.8583591338240606 1.015574115837423 0.4095002921319453 0.09201014435689979 793.6890915728497 875395.9153482082 0.02953703381238137 0.033513911346230336 5.199773764800614e-07 6.284015551525989 0.15721498201336237 FSGDLDDQTCR ddPTM_A459_Selumetinib_30min_R2 2 FSGDLDDQTCR 11 0 P05455 P05455 SSB Lupus La protein 0 ; 155.11 0.007354999999999999 36593600.0 118924.0 112500.0 116447.0 136078.0 134472.0 101974.0 113519.0 115327.0 99386.0 122087.0 False True 112314.68017049167 121128.38825548581 108954.92679790722 117543.94165235641 117578.42516506724 116019.99287219397 118797.85843363118 115662.58247658724 119265.97707685958 118562.03108987925 0.9473073220662727 1.0216456916435672 0.9189698067445462 0.9914130229706418 0.9917038708280363 0.9785594241738468 1.001989062953663 0.9755448807123251 1.0059373644370742 1.0 16.855282542258962 FSGEEGEIEDDES(ph)GTENR ddPTM_A459_Selumetinib_30min_R2 2 FSGEEGEIEDDESGTENR 18 0 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 FSGEEGEIEDDES(1)GTENR;FSGEEGEIEDDES(0.847)GT(0.153)ENR 289.5 1.0538999999999995e-80 44014000.0 73139.0 57580.0 58806.0 90280.0 79067.0 74906.0 99533.0 103933.0 91258.0 52742.0 True False 69074.22717861478 61996.200851118796 55022.48598313168 77983.70825831349 69133.89659205163 85223.62157103332 104161.4817208979 104235.4278229655 109512.14996156457 51219.2014198269 1.3486002370953838 1.2104093607972601 1.074255053922659 1.5225483040843755 1.3497652184262672 1.6638998502238136 2.0336412679908964 2.035084986362479 2.1381073293964423 1.0 15.644397138993286 -6.8384511582735845 2.2694981117473882 1.8887297173345876 1.2784503609146896 0.34932450357053735 0.31779077203382655 0.28288629055050324 2.9823746913843903 0.12136895207274889 0.10657050077677552 1.4506039032833926e-07 6.8384511582735845 -0.6102793564198981 FSGEEGEIEDDES(ph)GTENREEK ddPTM_A459_Selumetinib_30min_R1 2 FSGEEGEIEDDESGTENREEK 21 1 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 FSGEEGEIEDDES(0.94)GT(0.06)ENREEK;FSGEEGEIEDDES(0.979)GT(0.021)ENREEK 122.44 3.9912e-05 39953000.0 3011.0 4511.2 1913.5700000000002 2217.96 2614.5 2404.15 3578.3 3380.2 2195.6 4107.5 True False 3081.1504416138914 3983.02660680002 1653.7177044876134 1830.634922265625 2378.018936627466 2379.966433793548 3308.385950094141 3290.546115562989 3725.77283972071 4634.737635438138 0.6647950076083691 0.8593855618374159 0.3568093459795771 0.3949813487322824 0.5130859875313446 0.5135061833049286 0.7138237825583816 0.7099746251875857 0.8038799890705141 1.0 12.178271957328306 -8.233003873347187 0.9487053524604242 0.9868926836807486 0.5505767841972612 0.5167759582882588 0.13660766446456724 0.4717450548522613 0.8761682518538179 0.14189798437599932 0.050583294457328266 5.84784868593695e-09 8.233003873347187 -0.43631589948348737 FSGEEGEIEDDES(ph)GTENREEK ddPTM_A459_Selumetinib_30min_R2 3 FSGEEGEIEDDESGTENREEK 21 1 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 FSGEEGEIEDDES(0.946)GT(0.054)ENREEK;FSGEEGEIEDDES(0.908)GT(0.092)ENREEK;FSGEEGEIEDDES(0.825)GT(0.175)ENREEK 76.959 0.001489 79875000.0 145015.0 92121.0 111385.0 133956.0 120817.0 114072.0 164311.0 145446.0 119564.0 109880.0 True False 136955.64684103997 99186.38448429844 104218.61036681852 115710.96171301078 105638.8883423161 129784.3825574844 171951.78707606957 145869.2237801186 143480.14089728566 106707.47889747421 1.2834681154132463 0.9295167078176205 0.9766757817130417 1.0843753681425388 0.9899857951270237 1.216263226330956 1.6114314465369652 1.3670009383341486 1.3446118527000628 1.0 16.703301769532352 -6.9805330863047566 5.816586247858324 1.3689756020954629 1.047144444963463 0.3773533058324 0.16588532970924083 0.14818678303376667 16.607099195073033 0.0577478373388869 0.04942061905573808 1.0458440108143418e-07 6.9805330863047566 -0.32183115713199983 FSGEEGEIEDDES(ph)GTENREEKDNIQPTTE ddPTM_A459_Selumetinib_30min_R1 1 FSGEEGEIEDDESGTENREEKDNIQPTTE 29 2 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 FSGEEGEIEDDES(0.499)GT(0.499)ENREEKDNIQPT(0.001)TE 67.47800000000001 0.00020144 8206000.0 904.31 824.96 627.85 882.78 863.13 954.69 767.84 945.56 415.59 680.11 True False 925.3786635190502 728.3732996865009 542.5914185331857 728.6190448329314 785.0600438979785 945.0866853891656 709.9212106084691 920.4806771882547 705.2258765073468 767.4087433323991 1.2058484758730814 0.9491334390114053 0.7070435713007833 0.9494536662026717 1.0230011720858565 1.2315297337963822 0.9250887701978793 1.1994659758385804 0.9189703435550797 1.0 9.58385139189348 -6.331837930956847 4.325625694989081 1.0648784775649798 0.9348128394079835 0.08801592187109741 0.14740082785986144 0.46155644457262085 16.78769915508328 0.046900260742861126 0.05424949154833839 4.6575987232290587e-07 6.331837930956847 -0.13006563815699623 FSGEEGEIEDDES(ph)GTENREEKDNIQPTTE ddPTM_A459_Selumetinib_30min_R2 4 FSGEEGEIEDDESGTENREEKDNIQPTTE 29 2 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 FSGEEGEIEDDES(0.838)GT(0.162)ENREEKDNIQPTTE;FSGEEGEIEDDES(0.814)GT(0.185)ENREEKDNIQPTTE;FS(0.001)GEEGEIEDDES(0.805)GT(0.194)ENREEKDNIQPTTE;FSGEEGEIEDDES(0.811)GT(0.189)ENREEKDNIQPTTE 80.835 2.9998000000000007e-05 118474000.0 219237.0 201367.0 209876.0 224409.0 210510.0 173461.0 160301.0 163609.0 134117.0 211761.0 True False 207052.68521524724 216811.20140304367 196372.8066557115 193844.1070728824 184063.85181672228 197353.67822781924 167755.31413040528 164085.07510307193 160944.14754208038 205646.90970884668 1.006835869833351 1.0542886431408247 0.9549027842613079 0.9426064673051757 0.8950479833483443 0.9596724721379527 0.8157443959061285 0.7978971108069765 0.7826237105626526 1.0 17.64980986681379 -6.099721393976671 0.7455265396642788 0.8422263524704402 1.0387645092912303 0.46209373338688653 0.06582060046511351 0.6554890834170393 0.7475400878979117 0.036367794013388244 0.07971905741762048 7.948379709519311e-07 6.099721393976671 0.19653815682079012 FSGEEGEIEDDESGT(ph)ENREEKDNIQPTTE ddPTM_A459_Selumetinib_30min_R1 1 FSGEEGEIEDDESGTENREEKDNIQPTTE 29 2 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 FSGEEGEIEDDES(0.325)GT(0.668)ENREEKDNIQPT(0.005)T(0.001)E 64.545 0.0023114 85426000.0 2170.4 2914.9 2012.4 1930.0 1839.7 1723.4 2312.7 2174.9 1208.3 1692.5 True False 2220.966097136764 2573.6221528997557 1739.1271333219445 1592.9617305869613 1673.2994598254163 1706.0641607220011 2138.251177034547 2117.21458692916 2050.396849259671 1909.7488613460844 1.16296238845317 1.3476233472320236 0.9106575050376637 0.8341210526834214 0.8761882222806998 0.8933447717934407 1.1196504526398319 1.1086350827494897 1.0736473736208703 1.0 10.899167215953227 -5.264997853790753 24.99979872686042 0.9743097448703735 1.2552928756916641 0.5373076659107754 0.10326309528367791 237.34366861055733 1667452.283809309 0.030608453551531172 0.06800223785823434 5.432530161495367e-06 5.264997853790753 0.28098313082129067 FSGFSAKPNNSGEAPS(ph)SPTPK ddPTM_A459_Selumetinib_30min_R1 1 FSGFSAKPNNSGEAPSSPTPK 21 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 FSGFSAKPNNSGEAPS(0.599)S(0.311)PT(0.09)PK 85.913 0.00058715 63021000.0 3263.5 4200.2 3454.1 4077.3 2921.4 3574.0 3299.4 3324.2 1838.7 3364.7 True False 3339.53320033442 3708.438631379993 2985.052192013179 3365.2760954001114 2657.1598858150633 3538.0488049323612 3050.523601637819 3236.031417476627 3120.139606665362 3796.5920199534257 0.879613396115021 0.9767809161189476 0.7862451841875278 0.8863939232115319 0.6998802799589879 0.9319012383573845 0.80348996826771 0.8523516354850066 0.8218264143914094 1.0 11.890489260597311 -5.304862253142289 0.005201992101764656 1.6989188455569204 3.9400357708029514e-07 0.03877871177625958 0.08497919474221192 137601.15212079763 133.4223155569938 21104.87023789495 22481.740115568387 4.956073595784217e-06 5.304862253142289 -1.6989184515533433 FSGFSAKPNNSGEAPS(ph)SPTPK ddPTM_A459_Selumetinib_30min_R2 1 FSGFSAKPNNSGEAPSSPTPK 21 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 FSGFSAKPNNSGEAPS(0.493)S(0.493)PT(0.014)PK 88.471 0.00048408 52230000.0 209800.0 182290.0 199640.0 189560.0 177700.0 139800.0 197070.0 205150.0 154990.0 181560.0 True False 198140.15589594317 196271.05684526623 186795.37975159695 163741.60099076037 155375.73734184392 159056.18102195382 206234.14548679694 205746.95253558934 185992.33078242932 176317.89105046802 1.1237665940504522 1.1131658601173204 1.059423854486383 0.9286726378997585 0.8812250215570593 0.9020989309384756 1.1696722565026931 1.1669091055353977 1.0548693026800788 1.0 17.42781934739439 -9.757762755342391 13.31887462838756 0.9999971483072894 1.041781716421763 0.01645639255624054 0.10119090685805858 0.0 0.0 0.11167897771403644 0.027086130663292535 1.746776114223233e-10 9.757762755342391 0.04178456811447373 FSGFSAKPNNSGEAPSS(ph)PTPK ddPTM_A459_Selumetinib_30min_R2 1 FSGFSAKPNNSGEAPSSPTPK 21 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 FSGFSAKPNNSGEAPS(0.169)S(0.74)PT(0.091)PK 70.907 0.0031943 53696000.0 116580.0 79220.0 102230.0 102950.0 98133.0 97476.0 107760.0 102960.0 70207.0 93355.0 True False 110100.95030671607 85295.91926755178 95652.63309960825 88928.03240134427 85804.65521984894 110902.43420097248 112771.053522389 103259.59655405447 84250.36174748029 90659.59858458041 1.2144433907237957 0.9408371600937037 1.0550745270548447 0.9809003546202482 0.9464486558452817 1.2232839757999439 1.2438953545242077 1.1389814003833136 0.9293043766223975 1.0 16.468172152936184 -6.7532575101094885 24.99998112412917 1.124329509319937 1.0216624751767989 0.09829287507709406 0.11398577668822758 354.6884104820159 1083760.8487777435 0.03832970301521602 0.037709233656228094 1.764990978481244e-07 6.7532575101094885 -0.10266703414313816 FSGWYDADLS(ph)PAGHEEAK ddPTM_A459_Selumetinib_30min_R1 2 FSGWYDADLSPAGHEEAK 18 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 1 FSGWYDADLS(0.999)PAGHEEAK;FSGWYDADLS(1)PAGHEEAK 112.64 0.00080803 14971500.0 4657.2 5739.8 4440.3 5129.8 3962.4 4896.0 4247.200000000001 4166.0 2751.27 3751.2 True False 4765.703698666296 5067.781547639371 3837.331648822016 4233.976728272014 3604.0016196185406 4846.75068521232 3926.8302845596613 4055.50414692486 4668.704245189652 4232.703059782236 1.1259244107975488 1.1972920084547811 0.9065912714934081 1.0003009113731318 0.8514657344765307 1.1450722190423808 0.9277358295863279 0.9581357561929958 1.1030077421565803 1.0 12.047363566324327 -5.253051303764624 24.998066266305518 0.9842728152287047 1.1616082255092877 0.4098355281843219 0.0839982576075514 566.3975813454493 1687962.3095313276 0.020547328174001234 0.05246025486396603 5.584042258324252e-06 5.253051303764624 0.17733541028058297 FSHEEIAMATVTALR ddPTM_A459_Selumetinib_30min_R1 1 FSHEEIAMATVTALR 15 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BR68;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 102.15 0.0091052 10938000.0 4203.5 3825.1 4224.5 4309.7 3817.2 3450.9 3445.2 3814.4 2398.1 3387.8 False True 4301.433371412821 3377.2555137592553 3650.8361035174676 3557.0917980884046 3471.934933981395 3416.187079166504 3185.3257902535674 3713.229721082617 4069.4005497058847 3822.6571299664784 1.1252469748576537 0.8834837650712533 0.9550519388458684 0.9305286027888139 0.9082517254200722 0.8936681902194198 0.8332753061432691 0.9713739932294632 1.064547619980129 1.0 11.900360089312732 -8.004222475765198 24.847560330285468 1.0275028325410362 0.9272911790905072 0.22061667727475298 0.0737207161605185 220.38351685328067 1296859.0357681988 0.04105807855653242 0.018966262341839464 9.90324502011002e-09 8.004222475765198 -0.10021165345052907 FSIAILGS(ph)YNR ddPTM_A459_Selumetinib_30min_R1 1 FSIAILGSYNR 11 0 P56199 P56199 ITGA1 Integrin alpha-1 1 FSIAILGS(0.999)Y(0.001)NR 80.17 0.034874 0.0 1120.9 1004.5 1678.9 1653.4 1244.7 1293.9 1251.3 1137.1 676.32 936.17 True False 1147.0147891082738 886.8926730206189 1450.914601537573 1364.664728161907 1132.1171047696341 1280.884540767202 1156.91343357259 1106.9404141786508 1147.665643541589 1056.3365385680147 1.0858421982289697 0.8395929144161799 1.3735344263528497 1.2918844310846869 1.0717390371674056 1.212572408508739 1.0952129282027099 1.0479050697983385 1.0864583412946989 1.0 10.044853821227342 -7.521163493396835 5.5597218685401115 1.0533103053366268 1.1463742465110718 0.09971400782756468 0.13583490386708644 0.47166139934630114 51.361914321897224 0.06647465959087012 0.04027213451761597 3.0118719690713936e-08 7.521163493396835 0.09306394117444494 FSIGDSPDSST(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 FSIGDSPDSSTPK 13 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 FSIGDSPDS(0.004)S(0.045)T(0.952)PK 122.46 0.006181 3653900.0 44744.0 37150.0 40444.0 40065.0 30844.0 31043.0 34541.0 38771.0 18763.0 19134.0 True False 42257.30760442361 39999.28554392258 37841.87707209771 34608.07788401998 26969.100971141423 35318.89146970324 36147.22494169305 38883.81719111544 22516.12428202281 18581.551703897625 2.274153863886395 2.1526342999402157 2.0365294392588367 1.8624966545049446 1.4513912186076712 1.9007503804052504 1.9453286527255358 2.0926033417843817 1.2117461792655282 1.0 14.18158336254255 -10.156939720568928 0.11989297128022887 1.4666013319114892e-16 2.5936308337421203 0.6356837486044219 0.2439085299921557 24.776172034426192 0.7043054029667076 12.142132326968472 3.815917212084576 6.967232115500772e-11 10.156939720568928 2.5936308337421203 FSKEEPVS(ph)SGPEEAVGK ddPTM_A459_Selumetinib_30min_R2 1 FSKEEPVSSGPEEAVGK 17 1 O00567 O00567 NOP56 Nucleolar protein 56 1 FSKEEPVS(0.648)S(0.352)GPEEAVGK 102.87 0.016181 7075000.0 47508.0 47968.0 48841.0 40850.0 41949.0 34022.0 28353.0 33972.0 21810.0 52705.0 True False 44867.69554959231 51646.991358570085 45698.623234060055 35286.15952981945 36678.991591181824 38708.22167903371 29671.470680403665 34070.85289563265 26172.609422316094 51183.26970596445 0.876608622453126 1.0090600240131122 0.8928429835879503 0.6894080767510543 0.7166207200496137 0.7562670751869335 0.5797103399384039 0.6656638603075085 0.511350868607485 1.0 15.643384692575586 -5.706837546412195 3.8772606628194763 0.6851674129206381 0.9445807469402693 0.40016378832488453 0.12489094184367247 0.1923020412972147 5.867016752230046 0.03335708833472394 0.05870994142796003 1.9640948350598077e-06 5.706837546412195 0.2594133340196312 FSKEEPVSS(ph)GPEEAVGK ddPTM_A459_Selumetinib_30min_R1 4 FSKEEPVSSGPEEAVGK 17 1 O00567 O00567 NOP56 Nucleolar protein 56 1 FSKEEPVS(0.034)S(0.966)GPEEAVGK;FSKEEPVS(0.169)S(0.831)GPEEAVGK;FSKEEPVS(0.114)S(0.886)GPEEAVGK;FSKEEPVS(0.021)S(0.979)GPEEAVGK 180.1 3.7463e-07 31674000.0 10362.109999999999 13930.3 20257.6 24987.600000000002 16519.0 15121.24 13043.609999999999 13735.86 6440.219999999999 10708.68 True False 10603.527001843817 12299.333999979219 17506.7291870317 20623.984735344424 15024.859366666333 14969.134054587419 12059.719996229334 13371.540372438634 10928.582964941761 12083.24338937643 0.8775398012065554 1.0178834939957242 1.4488435449726675 1.7068252348104649 1.2434458930022187 1.2388341087086154 0.9980532219380951 1.106618474986184 0.9044411846036433 1.0 13.560720135016538 -7.202385534564619 3.4245914766379966 1.0080848279349652 1.2785809495105127 0.24633784893091404 0.21533707908334876 0.40716626001711925 9.560191421249312 0.10118132461763166 0.07360917403465789 6.275010623898218e-08 7.202385534564619 0.2704961215755475 FSKEEPVSS(ph)GPEEAVGK ddPTM_A459_Selumetinib_30min_R2 2 FSKEEPVSSGPEEAVGK 17 1 O00567 O00567 NOP56 Nucleolar protein 56 1 FSKEEPVS(0.102)S(0.898)GPEEAVGK;FSKEEPVS(0.238)S(0.762)GPEEAVGK 136.53 0.00028253 19747400.0 114466.0 120998.0 114055.0 112885.0 122687.0 69465.0 78971.0 79668.0 61714.0 110371.0 True False 108104.43796370355 130278.15753010914 106716.82547369463 97509.86826251338 107273.96222430399 79033.17320951381 82643.30797806785 79899.82069025266 74058.52443323312 107184.30245170282 1.008584610721475 1.2154593028098717 0.9956385686400409 0.9097401954586705 1.0008365009665625 0.737357723115529 0.7710392854896534 0.7454433052475707 0.690945621133317 1.0 16.709734107533293 -6.166757587453176 0.9858435819750354 0.7718359999376826 1.1087488702490307 0.5478108884795814 0.10649930167487986 0.38169323269395644 0.7749420277700023 0.0463283401209619 0.08115903316447541 6.811494535522175e-07 6.166757587453176 0.3369128703113481 FSLPS(ph)VDGQK ddPTM_A459_Selumetinib_30min_R1 2 FSLPSVDGQK 10 0 H0Y8J6;D6RDW9;A0A2R8Y437;A0A2R8Y833;A0A2R8Y4F3;A0A2R8YE73;P31785-2;P31785 H0Y8J6 IL2RG Cytokine receptor common subunit gamma 1 FSLPS(1)VDGQK;FSLPS(1)VDGQK 106.04 0.012142 89398000.0 4364.9 5224.4 5710.8 6024.3 5043.9 4545.2 4380.5 4605.0 2459.3 4203.4 True False 4466.593677383086 4612.724819242334 4935.304727178968 4972.269095116594 4587.68013557287 4499.479414711407 4050.075358239218 4482.860440851893 4173.252479834739 4742.94733458324 0.9417337706482383 0.9725439676735629 1.040556510335494 1.0483500541659512 0.9672635624945194 0.9486673785946167 0.8539153131024795 0.9451634447140238 0.8798858990917806 1.0 12.211568133564995 -6.754811205286478 2.7443011351942874 0.9146775328027552 1.0013615936424467 0.35966531676074387 0.04697388697426811 0.2702670399882074 4.176054351154113 0.017495615926708202 0.016298075824069128 1.7586879774207824e-07 6.754811205286478 0.08668406083969149 FSLS(ph)PSLGPQASR ddPTM_A459_Selumetinib_30min_R2 2 FSLSPSLGPQASR 13 0 Q9NYF3 Q9NYF3 FAM53C Protein FAM53C 1 FS(0.175)LS(0.593)PS(0.231)LGPQASR;FS(0.158)LS(0.589)PS(0.253)LGPQASR 156.2 0.00036531 14938500.0 51125.0 52805.0 61276.0 63795.0 69380.0 48564.0 54221.0 54073.0 42873.0 50156.0 True False 48283.67716959052 56854.97370516375 57333.568872264324 55106.0109474867 60663.864134930336 55253.25017990106 56742.38393687324 54230.34347773296 51448.797971708336 48707.86595906181 0.9912911645558888 1.1672647237912137 1.177090552898628 1.1313575305024126 1.2454633957052716 1.1343804351096092 1.1649531922536764 1.1133795827415782 1.0562728823913212 1.0 15.571867155219644 -8.347479854926574 1.7855147071253479 1.0018145166099468 1.149771981612324 0.3791303039779451 0.060332429276754564 0.3405471665505132 2.1599996653321365 0.05637842259464221 0.01642917274585159 4.492831645216011e-09 8.347479854926574 0.14795746500237716 FSMPDLS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 FSMPDLSK 8 0 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 FS(0.212)MPDLS(0.788)K 113.26 0.0076265 0.0 47604.0 38140.0 34983.0 46218.0 41518.0 36368.0 43735.0 33210.0 27979.0 38447.0 True False 44958.360253910745 41065.21536057087 32732.231866610484 39923.02866950293 36302.13766437068 41377.36188416609 45768.764159258404 33306.635601788556 33575.581798577834 37336.935212697404 1.2041256197863148 1.0998550129150817 0.876671630388105 1.0692636779658886 0.972284882451337 1.1082152739225 1.225830773161412 0.892055960459812 0.8992591814863148 1.0 15.18831588893176 -4.99641087212076 6.494099156491381 1.0124431760706853 1.181860832784877 0.26828705609337744 0.10294883439134238 0.18872396190086538 40.585177301779936 0.02725641842744014 0.09538415434065388 1.008298515717505e-05 4.99641087212076 0.16941765671419162 FSMPS(ph)LKGEGPEFDVNLSK ddPTM_A459_Selumetinib_30min_R1 1 FSMPSLKGEGPEFDVNLSK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 FS(0.017)MPS(0.982)LKGEGPEFDVNLS(0.001)K 54.964 0.032462 7230500.0 1573.9 965.46 1477.3 2149.7 1257.9 1644.0 1213.9 1194.1 798.93 953.3 True False 1610.5688077237146 852.4234943698233 1276.6907742280403 1774.2952498667307 1144.123167100283 1627.4628526325694 1122.3345456835032 1162.4285890165565 1355.7258584614985 1075.6653409283444 1.497276844797961 0.7924616160209699 1.1868847360334231 1.6494863061548857 1.0636423091524512 1.5129825148293803 1.043386360961376 1.0806600759427014 1.2603602690140132 1.0 10.071013583671009 -8.517948270149661 0.6841832530823458 1.0145908730238709 1.2500143958040921 0.08135252526930858 0.24527545590383815 2.3110685778159823 2.4814713186222797 0.2443345231589105 0.09812407488102828 3.034252579723629e-09 8.517948270149661 0.23542352278022127 FSNS(ph)MESLSSR ddPTM_A459_Selumetinib_30min_R1 1 FSNSMESLSSR 11 0 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 FS(0.012)NS(0.98)MES(0.008)LSSR 110.55 0.0087584 7876700.0 1839.1 2451.7 2286.2 2409.7 2314.4 1952.2 2756.4 2751.7 1163.8 1865.8 True False 1881.9474517343442 2164.653824235592 1975.7465971976887 1988.891130671191 2105.062928640507 1932.5626404557788 2548.4825288096276 2678.715977218708 1974.8835994110786 2105.293604431034 0.8939121117232244 1.028195696638047 0.938466061474425 0.944709624579275 0.999890430584104 0.9179539786699078 1.2105116946376548 1.2723716880062645 0.9380561434540626 1.0 11.039805730361785 -7.2525800605193815 24.974111707454036 1.127932523404897 0.9582111566642512 0.362084910203763 0.09646965280684272 616.7395676235645 1738569.5968727095 0.03616002074043075 0.027588012340061835 5.5901046663934176e-08 7.2525800605193815 -0.16972136674064575 FSNS(ph)MESLSSR ddPTM_A459_Selumetinib_30min_R2 1 FSNSMESLSSR 11 0 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 FS(0.012)NS(0.988)MESLSSR 160.46 0.0005996 4071200.0 19771.0 21058.0 19758.0 22210.0 19422.0 18447.0 21688.0 18342.0 14429.0 20360.0 True False 18672.206969583833 22673.080887857916 18486.791790883857 19184.959685612972 16982.034725116995 20987.90680480673 22696.53497395671 18395.372183318435 17315.203179944936 19772.15389836706 0.9443688869489292 1.1467178034523813 0.9349912956327252 0.9703019602329424 0.8588864325256695 1.0614881369368703 1.1479040215153882 0.9303676411722482 0.8757368200221707 1.0 14.27118242053219 -5.307261779656387 24.99422075030851 0.9752849017095682 1.045544127127316 0.09031368703061593 0.0924316767506204 1002.0813266615623 546591.7331314819 0.02523531867586542 0.052531905599433215 4.928766231882691e-06 5.307261779656387 0.07025922541774787 FSPAGPILS(ph)IR ddPTM_A459_Selumetinib_30min_R1 1 FSPAGPILSIR 11 0 P11940;E7ERJ7;P11940-2;A0A087WTT1;Q9H361;H0YBN4;E5RH24;E5RJB9;E5RHG7;E5RFD8;E5RGC4;Q4VXU2;Q5JQF8;Q4VXU2-2 P11940 PABPC1;PABPC3;PABPC1L;PABPC1L2A Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 1-like 2 1 FSPAGPILS(1)IR 94.191 0.022537 6676700.0 629.35 1190.3 1499.1 1397.2 1100.7 853.24 1033.5 776.26 778.74 763.6 True False 644.0126304980748 1050.9391226445425 1295.530453966868 1153.2052486922805 1001.1418793443692 844.6571802799355 955.5422629243764 755.6710631521581 1321.464903080756 861.6154980938679 0.7474478255356468 1.2197309878588662 1.5036062568894595 1.3384221282503506 1.1619357840697762 0.9803179981657143 1.109012390141891 0.8770397756585295 1.533706051021833 1.0 9.750900390007445 -6.524194580143741 24.869182243356104 1.0904741367096173 1.2282073025955187 0.03379889877914832 0.24121894245117456 129.76679983104097 2452505.263365641 0.08003635654849743 0.0806576366917852 2.9909242906096534e-07 6.524194580143741 0.13773316588590134 FSPAGPILS(ph)IR ddPTM_A459_Selumetinib_30min_R2 1 FSPAGPILSIR 11 0 P11940;E7ERJ7;P11940-2;A0A087WTT1;Q9H361;H0YBN4;E5RH24;E5RJB9;E5RHG7;E5RFD8;E5RGC4;Q4VXU2;Q5JQF8;Q4VXU2-2 P11940 PABPC1;PABPC3;PABPC1L;PABPC1L2A Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 1-like 2 1 FSPAGPILS(1)IR 88.338 0.030787 1886800.0 5468.9 4055.6 4571.2 4500.6 4675.2 4827.4 3525.7 5752.4 5432.7 6505.4 True False 5164.960431741289 4366.651479190645 4277.093968746243 3887.6105160319576 4087.8595791817024 5492.330531225893 3689.652036042013 5769.138531638916 6519.3918023208025 6317.572198940921 0.8175546347704808 0.6911913851847504 0.6770154473997553 0.6153646359092939 0.6470617905826216 0.8693736071819849 0.5840300545612359 0.9131891729873788 1.031945753372429 1.0 12.625154531439392 -7.929437171387584 5.2285188912311344 1.0037750215328851 0.7008775507880753 0.7177167156573612 0.0823897300362735 0.1021010391251183 5.109985687785721 0.04701516338071428 0.021647033940705454 1.176421163137845e-08 7.929437171387584 -0.30289747074480977 FSPPS(ph)PLPQAVFSTSSR ddPTM_A459_Selumetinib_30min_R1 1 FSPPSPLPQAVFSTSSR 17 0 A0A1X7SBS4;Q99594 A0A1X7SBS4 TEAD3 Transcriptional enhancer factor TEF-5 1 FS(0.11)PPS(0.831)PLPQAVFS(0.021)T(0.021)S(0.006)S(0.01)R 80.545 0.016465 11184000.0 534.81 481.39 779.08 892.61 846.89 513.02 487.54 573.19 485.29 581.92 True False 547.2700324408922 425.02863500786054 673.2852151801136 736.7324198648842 770.2889490305738 507.859484584891 450.76446527929414 557.9871392164816 823.501685820762 656.615100380806 0.8334715910790069 0.6473025593858013 1.025387955271878 1.1220156518447624 1.1731209784603527 0.7734508150823158 0.6864972569437893 0.8497933399534602 1.2541619669471042 1.0 9.358904118171761 -5.267686893911319 24.830905671080842 0.9735057868423636 0.7403870725640798 0.24107771618551532 0.17294309222249526 667.4571956514374 2652835.2270955923 0.04930110175452394 0.10690082333927782 5.398997247848654e-06 5.267686893911319 -0.2331187142782838 FSPPS(ph)PLPQAVFSTSSR ddPTM_A459_Selumetinib_30min_R2 1 FSPPSPLPQAVFSTSSR 17 0 A0A1X7SBS4;Q99594 A0A1X7SBS4 TEAD3 Transcriptional enhancer factor TEF-5 1 FS(0.063)PPS(0.865)PLPQAVFS(0.031)T(0.031)S(0.007)S(0.002)R 73.597 0.024754 6124500.0 8486.0 7669.0 10034.0 8641.5 9665.1 5799.7 8103.7 8337.4 6531.0 8144.2 True False 8014.382092149533 8257.187640278398 9388.423364193166 7464.512792581021 8450.88373090971 6598.556030565276 8480.53810717692 8361.660453669125 7837.38249138682 7909.055784827168 1.0133171784581951 1.0440168668577468 1.187047306228897 0.943793165158986 1.0685072859293763 0.8343038929152616 1.0722567064764028 1.0572261318108591 0.9909378192049363 1.0 12.949289754852254 -5.791195206986203 24.999962326215343 0.997223727121972 1.077716420822522 0.20289608714290563 0.07809783613985073 339.7783639010209 285470.51384650264 0.02195230415519322 0.03256531704218311 1.6173529053289968e-06 5.791195206986203 0.08049269370055001 FSPT(ph)MGR ddPTM_A459_Selumetinib_30min_R1 2 FSPTMGR 7 0 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 FS(0.21)PT(0.79)MGR;FS(0.329)PT(0.671)MGR 107.01 0.019188 122609000.0 7768.799999999999 13449.3 7116.9 7228.0 7594.6 8440.0 10610.3 8480.7 3800.3999999999996 9834.2 True False 7949.797924546665 11874.649703590065 6150.464070333403 5965.7654863640155 6907.669770935533 8355.101262906861 9809.956528598459 8255.764286804053 6449.001229766168 11096.515363219893 0.7164229187567096 1.0701242070055026 0.55426986481896 0.5376251274465789 0.6225080166906671 0.7529481994501064 0.8840574006786117 0.7439961119837953 0.5811735503148847 1.0 13.437819077973892 -10.756083572492678 4.157513522059899 1.0001758966240286 0.7222030917406477 0.22859798406492404 0.15517685418853444 117959108.22094141 64.7422470830899 203488.75176868876 0.039634461620967475 1.7535430302196708e-11 10.756083572492678 -0.27797280488338094 FSPT(ph)MGR ddPTM_A459_Selumetinib_30min_R2 1 FSPTMGR 7 0 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 FS(0.31)PT(0.69)MGR 97.473 0.0094131 16888000.0 227640.0 159050.0 197280.0 223510.0 239820.0 203100.0 255670.0 253930.0 229940.0 166820.0 True False 214988.68011512142 171248.62357364426 184587.21958222322 193067.55242374438 209691.667581998 231075.18144176528 267559.1616004937 254668.89425962575 275934.4250604023 162003.47314958725 1.3270621668500269 1.0570676062945912 1.139402853491808 1.191749464812238 1.2943652596162394 1.4263594289018735 1.651564354755782 1.5719965091394992 1.7032624035511632 1.0 17.30566521743544 -6.68379675959946 2.0545262766288768 1.5295449083238593 1.168006520350845 0.329118426421221 0.1921408042639019 0.30535613153353675 2.6464487704494073 0.07056625703060267 0.06837606962621089 2.0711103567742053e-07 6.68379675959946 -0.3615383879730143 FSS(ph)KNQLK ddPTM_A459_Selumetinib_30min_R1 3 FSSKNQLK 8 1 H7C5R8;Q460N5-5;Q460N5-3;Q460N5-4;Q460N5-1;Q460N5 H7C5R8 PARP14 Poly [ADP-ribose] polymerase 14 1 FS(0.092)S(0.908)KNQLK;FS(0.274)S(0.726)KNQLK;FS(0.044)S(0.956)KNQLK 143.61 0.0011773 12883700.0 6268.5 6927.200000000001 7060.3 7718.8 6866.5 6491.200000000001 6948.9 6715.5 3953.31 5904.0 True False 6414.543853622282 6116.160203632093 6101.550039451856 6370.8564798210555 6245.426287379035 6425.904421538034 6424.738878408513 6537.383124981731 6708.478331661635 6661.835909830007 0.9628792934027648 0.9180892904622986 0.9158961766753501 0.9563214354199883 0.937493263405583 0.9645846142887068 0.9644096560421669 0.9813185454381071 1.00700143661041 1.0 12.701704103551265 -7.457431123521546 0.7820868141395125 1.0049349090239892 0.933709902423604 0.7456909849931264 0.01472642470687859 0.32115413665033826 0.3719395075008435 0.012719103169842998 0.006826959404135795 3.4879389635165767e-08 7.457431123521546 -0.07122500660038522 FSS(ph)PAPSSDGK ddPTM_A459_Selumetinib_30min_R1 1 FSSPAPSSDGK 11 0 Q96QT6;Q96QT6-4;Q96QT6-5;Q96QT6-3 Q96QT6 PHF12 PHD finger protein 12 1 FS(0.024)S(0.976)PAPSSDGK 129.82 0.0034510999999999995 0.0 2515.1 3219.3 3385.9 3375.1 3076.3 2671.5 3153.7 2867.4 1670.8 2416.7 True False 2573.696936467322 2842.3828593880335 2926.1133774173964 2785.7021434736007 2798.0492081648795 2644.6271355279227 2915.8138699415645 2791.3472373721415 2835.225569596175 2726.906985651452 0.9438154473217103 1.0423468326364622 1.0730521403238675 1.0215611159938784 1.0260889802577668 0.9698266752197736 1.0692751477348184 1.0236312613740637 1.0397221410611648 1.0 11.41304977566408 -7.30009584338182 24.99895988798965 1.0351263841655318 1.0178691337819255 0.05542068771129538 0.03751107548526065 2152.490393324983 1391998.595002951 0.015905600175923282 0.01072415376073472 5.0107664005224135e-08 7.30009584338182 -0.01725725038360637 FSS(ph)PAPSSDGK ddPTM_A459_Selumetinib_30min_R2 2 FSSPAPSSDGK 11 0 Q96QT6;Q96QT6-4;Q96QT6-5;Q96QT6-3 Q96QT6 PHF12 PHD finger protein 12 1 FS(0.032)S(0.968)PAPSSDGK;FS(0.049)S(0.95)PAPSS(0.001)DGK 122.18 0.0034084 0.0 86490.0 87098.0 89461.0 86525.0 93539.0 70638.0 79328.0 74923.0 61963.0 84678.0 True False 81683.23204690227 93778.13653578922 83705.17665777226 74740.14573604957 81787.79457073017 80367.74331207991 83016.90918544997 75141.0135258296 74357.33139087446 82233.12612013413 0.9933129859075464 1.1403936705359958 1.0179009434164965 0.9088812412027474 0.9945845236534803 0.9773159200426227 1.0095312327561379 0.9137560137997955 0.904226008412304 1.0 16.327432054017272 -5.526423298267542 14.238183060591775 0.9594900726225664 1.0699296793128648 0.4448844822619463 0.0492309074423233 0.4060891341025551 1621.4340361816664 0.013036191359885423 0.02313789783070912 2.9756147425378044e-06 5.526423298267542 0.1104396066902984 FSS(ph)PIVK ddPTM_A459_Selumetinib_30min_R1 2 FSSPIVK 7 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 FS(0.079)S(0.921)PIVK;FS(0.11)S(0.89)PIVK 109.11 0.015983 70971000.0 19620.0 21206.1 23472.6 25047.0 20751.9 18790.4 19365.9 17921.6 11992.5 17150.0 True False 20077.107826125728 18723.279953551573 20285.1498457626 20673.011640420507 18874.894309045525 18601.38563631813 17905.11457142446 17446.260950438922 20350.396602455196 19351.36955514644 1.037503199394292 0.9675428863158768 1.0482539640388306 1.0682970826177303 0.9753776989921523 0.9612438842278812 0.9252634300843398 0.9015517429255615 1.0516256508079072 1.0 14.240148053438405 -6.4430977094971755 6.4334088649263945 0.9600297704670537 1.0270581514364647 0.29813432771397874 0.04519542031443794 0.29292170745067353 19.42810307669656 0.01426778460115627 0.016114350147128524 3.6049752756578006e-07 6.4430977094971755 0.067028380969411 FSS(ph)PIVK ddPTM_A459_Selumetinib_30min_R2 2 FSSPIVK 7 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 FS(0.005)S(0.995)PIVK;FS(0.004)S(0.996)PIVK 124.08 0.006782300000000001 49129000.0 440690.0 443610.0 448870.0 510850.0 507890.0 419420.0 432140.0 430720.0 379000.0 478750.0 True False 416198.2140218449 477633.4605690316 419990.1928927039 441271.34873459727 444084.3176057914 477191.29788431973 452235.3662691647 431973.3238904657 454810.59014478617 464927.24355811544 0.8951899889467771 1.027329473991833 0.9033460583606466 0.9491191468099864 0.9551694889015065 1.026378437693491 0.9727013689457752 0.9291202653226955 0.9782403514668103 1.0 18.82664544104354 -6.541789026465242 24.962517456150863 0.9779272679247447 0.9474948686019794 0.159723244388841 0.0403799124277206 540.3430105531277 713274.7152739946 0.013104988639590576 0.013106471953190521 2.872175501568428e-07 6.541789026465242 -0.030432399322765313 FSS(ph)PTEELDYR ddPTM_A459_Selumetinib_30min_R1 3 FSSPTEELDYR 11 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 FS(0.064)S(0.895)PT(0.04)EELDYR;FS(0.361)S(0.638)PT(0.001)EELDYR;FS(0.063)S(0.937)PTEELDYR 227.48 4.7319e-07 185118000.0 8187.400000000001 9228.1 10620.9 10069.6 9763.9 7811.9 9999.6 8800.6 4788.9 7367.400000000001 True False 8378.150490092861 8147.669761972702 9178.640116427667 8311.13338980231 8880.756968956552 7733.319378637692 9245.32212127585 8567.179499622402 8126.413532582672 8313.077554553112 1.007827779196419 0.9801027006550882 1.1041205926679323 0.999766131767923 1.0682875157459006 0.9302595011160597 1.1121419306634694 1.0305665312757868 0.9775457379357415 1.0 13.021166955488903 FSS(ph)PTEELDYR ddPTM_A459_Selumetinib_30min_R2 3 FSSPTEELDYR 11 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 FS(0.021)S(0.979)PTEELDYR;FS(0.128)S(0.85)PT(0.022)EELDYR;FS(0.121)S(0.879)PTEELDYR 230.81 2.9195e-07 90534000.0 148683.0 157304.0 180942.0 191027.0 186886.0 129035.0 146851.0 165112.0 132707.0 163537.0 True False 140419.7940852073 169368.71098791907 169300.38871475396 165008.79306004453 163407.70989796196 146808.39998689425 153679.86247973618 165592.44858423708 159252.10814338858 158815.26188984592 0.8841706547233622 1.0664511015660008 1.066020901896573 1.0389983374173097 1.0289169186479152 0.9243973043895516 0.9676643204878405 1.0426733968369601 1.0027506566330235 1.0 17.276990034240114 FSSSIENSDS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 FSSSIENSDSPVR 13 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 FSSSIENS(0.011)DS(0.989)PVR 94.532 0.015734 12348000.0 2869.2 3720.2 3890.9 4439.4 4695.0 3434.7 4079.0 3944.6 2426.9 3283.2 True False 2936.0467775086636 3284.637254525942 3362.5371511838343 3664.142127858938 4270.338078969577 3400.1500364580797 3771.317745978261 3839.9763941334154 4118.272046237108 3704.6307010761993 0.7925342670878743 0.886630144692088 0.9076578537793291 0.989070820687876 1.1527027721626986 0.917810791631763 1.0180009966668713 1.0365341930081986 1.1116552170883713 1.0 11.85511401821056 -5.509096458961472 1.5144186201407561 1.0363582534106814 0.8187931928731482 0.6273274379543143 0.0626223985723688 0.30269239127869024 1.2980425284893131 0.01970741325987419 0.0644820940890971 3.096731423399198e-06 5.509096458961472 -0.21756506053753322 FSSSIENSDS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 3 FSSSIENSDSPVR 13 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 FSSSIENS(0.005)DS(0.995)PVR;FSSSIENS(0.097)DS(0.903)PVR;FS(0.002)SS(0.002)IENS(0.011)DS(0.985)PVR 126.71 0.0020008 20116700.0 97134.0 91455.0 91360.0 94135.0 97520.0 69123.0 90761.0 81980.0 61760.0 87384.0 True False 91735.68113821033 98469.30442582618 85481.99706524675 81313.65060806728 85268.66576013852 78644.06581388059 94981.56633950966 82218.5482274805 74113.72571858064 84860.99686910151 1.08101111844954 1.1603599775962512 1.007317851770032 0.958198154724649 1.0048039606660035 0.9267398300209628 1.1192605536559885 0.9688614470827275 0.8733544084204127 1.0 16.372814005734803 -5.372861534824045 5.081418400702787 0.9823896276194716 1.1196412502670838 0.4459360488978974 0.06214485907435752 0.19423672184108842 7.3396646100338705 0.016453802128925808 0.03546026091622896 4.237780567597927e-06 5.372861534824045 0.13725162264761226 FSSVSS(ph)PQPR ddPTM_A459_Selumetinib_30min_R1 3 FSSVSSPQPR 10 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 FS(0.001)S(0.006)VS(0.158)S(0.835)PQPR;FS(0.002)S(0.001)VS(0.055)S(0.942)PQPR;FSSVS(0.026)S(0.973)PQPR 133.91 0.0021906 94474000.0 16156.5 18454.7 20139.4 20355.0 19405.800000000003 14917.0 17654.8 15705.400000000001 8759.099999999999 12970.9 True False 16532.915014923557 16294.015144642739 17404.580097805574 16800.38136067232 17650.548816372262 14766.948523552324 16323.084222038979 15288.841773671084 14863.552960647508 14635.841362265248 1.129618353034997 1.1132954191928224 1.1891752354380396 1.1478931032955701 1.2059811513043357 1.008957951787118 1.1152815760987853 1.0446165270067376 1.0155584904718464 1.0 13.837218063067048 -6.765939266667912 24.999992652830628 1.0445713523461448 1.1560140880265892 0.701342220676346 0.03909036095324088 70.16020837122738 389786.2185799444 0.01364080185708594 0.01243646864253761 1.7141970103402257e-07 6.765939266667912 0.11144273568044438 FSSVSS(ph)PQPR ddPTM_A459_Selumetinib_30min_R2 1 FSSVSSPQPR 10 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 FS(0.006)S(0.005)VS(0.092)S(0.898)PQPR 89.561 0.03067 11746000.0 221280.0 197200.0 227500.0 185000.0 201970.0 145580.0 186510.0 205460.0 133320.0 194000.0 True False 208982.1434540242 212324.60590206028 212862.89768327138 159802.68085719933 176596.7229652912 165632.3235563381 195183.08456255356 206057.85458426576 159987.72527203953 188398.71592746608 1.1092546062494544 1.1269960352798036 1.1298532298130104 0.8482153398472403 0.9373562982949487 0.879158452545435 1.036010694667895 1.0937327973275492 0.8491975355799939 1.0 17.523429606418347 -5.738580015789934 24.996757187782222 0.9532196511901043 1.1225308904814386 0.5254255347838049 0.07524609593445625 198.06054622248783 216577.85599603434 0.021157912873209873 0.036614984687232975 1.825660352644769e-06 5.738580015789934 0.1693112392913343 FSTLTDDPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 FSTLTDDPSPR 11 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 FSTLT(0.001)DDPS(0.998)PR;FSTLT(0.001)DDPS(0.999)PR 98.156 0.017649 2295900.0 43840.0 42142.0 52099.0 49863.0 52762.0 34500.0 44230.0 38627.0 36651.0 44957.0 True False 41403.54830542489 45374.15589211265 48747.007061102224 43071.573381527225 46133.56586173533 39252.06184018171 46286.78264008232 38739.39817495593 43982.22411450287 43658.97459768604 0.9483399160643435 1.0392858813160837 1.1165403564857397 0.9865456937188362 1.0566800133730223 0.8990605528848609 1.0601894127521618 0.8873180951210234 1.0074039649303619 1.0 15.413990626227088 -6.7291929946972395 24.99895970648294 0.9693388486131115 1.0324748699023965 0.17913845982395205 0.06260735937129952 317.29665469016606 245982.9060405162 0.019786812655780073 0.01978524696002227 1.8655504807574701e-07 6.7291929946972395 0.06313602128928497 FSTYTS(ph)DKDENK ddPTM_A459_Selumetinib_30min_R1 2 FSTYTSDKDENK 12 1 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 FSTYT(0.046)S(0.953)DKDENK;FSTYT(0.029)S(0.971)DKDENK 153.49 0.0049786000000000006 12876000.0 3422.1 4726.3 3955.0 3715.4 3725.0 3664.2 3754.2 3920.1000000000004 2545.65 4125.3 True False 3501.8282717525412 4172.942598802741 3417.9327232599294 3066.5751366957497 3388.074407702163 3627.3414748274067 3471.0176714762392 3816.1262137206327 4319.782123080262 4654.822438824821 0.7523011495657888 0.8964772885850962 0.7342777878596884 0.6587952982090445 0.7278632970922803 0.7792652721986927 0.7456820785526137 0.8198220799769261 0.9280229653981936 1.0 12.184510420971904 -8.282905289786434 1.7777303354643732 0.9984194075829325 0.7561675051602036 0.6887689090826443 0.05607394092394503 0.21204338801109646 1.2688684112387996 0.05736570151712582 0.016952481425009963 5.213083847695823e-09 8.282905289786434 -0.24225190242272887 FT(ph)GSFDDDPDPHRDPYGEEVDRR ddPTM_A459_Selumetinib_30min_R2 1 FTGSFDDDPDPHRDPYGEEVDRR 23 2 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 1 FT(0.528)GS(0.472)FDDDPDPHRDPYGEEVDRR 52.849 0.016496 8380700.0 13206.0 14913.0 18275.0 21343.0 13086.0 9704.9 10525.0 10714.0 8690.4 16915.0 True False 12472.063387806602 16056.779147147176 17099.206396315545 18436.046581271385 11442.01968967568 11041.66188268927 11014.433354891844 10745.175966201821 10428.722830064 16426.61999955201 0.759259262596124 0.977485273755957 1.0409449050858837 1.1223274527428146 0.6965535021804686 0.6721810015079426 0.6705234159670237 0.6541318887570824 0.6348672356424154 1.0 14.003748036250483 -6.2810288333972695 24.250982169497902 0.6990803337901794 0.9798914810637529 0.4695349868271915 0.13074467222705827 438.83242645846406 543255.9307080512 0.03980818062092934 0.04520875867765695 5.235656751994614e-07 6.2810288333972695 0.2808111472735735 FT(ph)SPADLDASGAGPGPK ddPTM_A459_Selumetinib_30min_R2 1 FTSPADLDASGAGPGPK 17 0 P52735-3;P52735-2;P52735 P52735-3 VAV2 Guanine nucleotide exchange factor VAV2 1 FT(0.594)S(0.406)PADLDASGAGPGPK 138.81 0.00071978 0.0 16401.0 15121.0 21483.0 24200.0 22032.0 17394.0 16432.0 17967.0 15725.0 18986.0 True False 15489.498078404962 16280.73207832176 20100.80716892185 20903.91825267151 19264.14319142095 19789.865612989022 17196.12055939029 18019.280995403024 18870.43939321049 18437.824848447795 0.8400935688305423 0.8830071991757947 1.0901940621598893 1.1337518619736386 1.0448164764425951 1.073329732528349 0.932654513248506 0.9772997163990302 1.0234634263162075 1.0 14.170380847385385 -5.152824290895717 5.162166701676503 1.034979615753911 0.8517250750742091 0.6173746843422423 0.05472439970231296 0.15677413740425927 6.091196808098342 0.0158277801796562 0.044655377907518334 7.0335683006425385e-06 5.152824290895717 -0.18325454067970193 FT(ph)SQDASTPASSELNK ddPTM_A459_Selumetinib_30min_R2 1 FTSQDASTPASSELNK 16 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 FT(0.589)S(0.411)QDASTPASSELNK 122.16 0.002353 0.0 14614.0 16791.0 13824.0 18312.0 22717.0 18401.0 14667.0 18815.0 14409.0 14060.0 True False 13801.812384477169 18078.815708425416 12934.57889043316 15817.874010038036 19863.087367443266 20935.57072235317 15349.044562109133 18869.748535009072 17291.202621098248 13654.051267732862 1.010821778375294 1.3240623866082237 0.9473070399991866 1.158474777915819 1.4547394746044016 1.5332863713371234 1.1241384890931136 1.3819889910331522 1.2663789143637296 1.0 13.73704145352903 -4.751242027669049 24.598878990146147 1.2553457637695602 1.0108211587193152 0.1273870884990912 0.1801609618426344 750.4191131694901 1810069.7669139702 0.04627056912525054 0.614292561688373 1.7732010195263022e-05 4.751242027669049 -0.24452460505024498 FTATMS(ph)TPDKK ddPTM_A459_Selumetinib_30min_R1 2 FTATMSTPDKK 11 1 H0Y322;Q5TKA1;Q5TKA1-2;C9J5J4;H7C4T7;Q5TKA1-3;B1B047 H0Y322 LIN9 Protein lin-9 homolog 1 FTATMS(0.998)T(0.002)PDKK;FTATMS(0.976)T(0.023)PDKK 259.18 1.2531e-21 42573000.0 9368.4 11774.400000000001 13631.7 12953.6 9374.2 10013.0 10054.8 9512.5 5560.7 8771.4 True False 9586.66549226689 10395.847774229942 11780.59001356825 10691.496929187184 8526.305265149434 9912.278311076594 9296.358340834073 9260.197599045308 9436.101762540975 9897.294630671222 0.9686147427154782 1.0503726687102684 1.190283855656958 1.0802443827482682 0.861478371950941 1.0015139167787264 0.939282772488668 0.9356291738904506 0.95340212802183 1.0 13.272818511238134 -6.233547463057189 23.90336781147026 0.9475172521041616 1.0792288680884972 0.4859738356255576 0.062224546845761924 360.45360745978826 308908.1437823805 0.018768087578123076 0.024222620571072755 5.840533737385749e-07 6.233547463057189 0.13171161598433556 FTDEEVDELYR ddPTM_A459_Selumetinib_30min_R1 3 FTDEEVDELYR 11 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 ;; 296.52 6.743499999999998e-53 66784300.0 8153.76 9859.3 6513.48 6922.1 7937.91 7476.120000000001 8782.3 8049.37 4859.6 7617.3099999999995 False True 8343.7267435449 8704.968572535778 5628.985191984601 5713.285178909847 7219.927442051835 7400.917020573844 8119.8440403297045 7835.874559561343 8246.386268858976 8595.06593738266 0.9707577352321862 1.012786712278159 0.6549089015713497 0.6647168527307001 0.8400083832574323 0.861065764299133 0.944709918397942 0.9116712561192399 0.9594325778226824 1.0 13.069292992099 -7.141573998930643 2.264835116025161 0.9501714433192022 0.8206485996007546 0.2328930575546989 0.10751873319298946 0.554413871593906 5.570808476867424 0.055116534271559596 0.039371068867672554 7.218151632141129e-08 7.141573998930643 -0.12952284371844758 FTDEEVDELYR ddPTM_A459_Selumetinib_30min_R2 4 FTDEEVDELYR 11 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 ;;; 224.02 6.3654e-05 86716900.0 125746.0 102118.4 144395.0 130927.0 138427.0 113017.1 109508.0 120121.0 100940.0 108122.6 False True 118757.54072112138 109950.55291759074 135104.782905389 113094.5167383273 121036.5627069186 128584.17965791318 114600.33898598528 120470.53222289802 121130.8204992474 105000.81960174763 1.1310153689423657 1.0471399493319835 1.286702174495601 1.0770822281890546 1.1527201708138293 1.2246016759260898 1.0914232805100683 1.147329446377892 1.1536178570670064 1.0 16.68004106357356 -10.713792075774716 4.69792814739982 0.9999771448285104 1.1459380993991704 0.30379242923393557 0.06618621680263082 1.5277966273628687e-05 2.6310388908554886e-06 0.06120763045192051 0.014842685052153052 1.9328934938450772e-11 10.713792075774716 0.14596095457065994 FTDKDQQPS(ph)GSEGEDDDAEAALKK ddPTM_A459_Selumetinib_30min_R2 2 FTDKDQQPSGSEGEDDDAEAALKK 24 2 H3BNW0;Q9NXG2 H3BNW0 THUMPD1 THUMP domain-containing protein 1 1 FT(0.001)DKDQQPS(0.561)GS(0.438)EGEDDDAEAALKK;FT(0.019)DKDQQPS(0.814)GS(0.167)EGEDDDAEAALKK 62.06399999999999 0.006703799999999999 14477200.0 61683.0 52385.9 54128.8 61943.0 53465.0 40893.8 35947.9 41990.0 36718.9 50331.8 True False 58254.90579661325 56403.730082782626 50646.21193898137 53506.25654236492 46748.24871683559 46526.54975304419 37619.54857941252 42112.183948181264 44063.70601178741 48878.590156278595 1.1918286843044357 1.1539557483643461 1.0361635181589974 1.0946767566595186 0.956415652893594 0.9518799458880818 0.7696528983166708 0.8615670749409255 0.9014929823242315 1.0 15.576915052515446 -6.1458305793305295 0.9547677816599044 0.8726819627501335 1.1670497477150006 0.7354682715067002 0.06428791044180972 0.28835144219241704 0.5486806554028738 0.02955577279113636 0.053917738451346106 7.147751094016583e-07 6.1458305793305295 0.29436778496486704 FTDKDQQPSGS(ph)EGEDDDAEAALKK ddPTM_A459_Selumetinib_30min_R2 1 FTDKDQQPSGSEGEDDDAEAALKK 24 2 H3BNW0;Q9NXG2 H3BNW0 THUMPD1 THUMP domain-containing protein 1 1 FTDKDQQPS(0.032)GS(0.968)EGEDDDAEAALKK 73.809 0.00062407 5124300.0 13280.0 11770.0 11083.0 13338.0 9445.2 6745.9 8449.0 10369.0 7183.2 8673.8 True False 12541.950764052068 12672.72115348503 10369.931846258014 11521.341390666628 8258.609534840649 7675.086491816867 8841.895241375889 10399.172073319642 8620.040715377396 8423.36485676111 1.4889478227914024 1.504472543809274 1.231091377685542 1.3677837285439312 0.9804406760573574 0.9111663358208176 1.0496868403223494 1.2345627015043312 1.023348847160339 1.0 13.040180942233398 -5.812691278268375 1.325416189038296 1.0431655524570729 1.4888446538563755 0.7269578835954877 0.10805103582922208 0.25780022973981737 0.9096103281562353 0.039812560565064915 0.09203344489683773 1.5392484386438187e-06 5.812691278268375 0.44567910139930267 FTGS(ph)FDDDPDPHRDPYGEEVDR ddPTM_A459_Selumetinib_30min_R2 1 FTGSFDDDPDPHRDPYGEEVDR 22 1 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 1 FT(0.252)GS(0.748)FDDDPDPHRDPYGEEVDR 76.152 0.00074216 4014700.0 6640.7 6619.8 8286.5 9210.6 7615.9 6939.8 6877.7 10109.0 8705.0 7065.4 True False 6271.636478828353 7127.517373988126 7753.355611659029 7956.100390828762 6659.122554990141 7895.694456767924 7197.526677904004 10138.415516364958 10446.243238022094 6861.403543886185 0.9140457107229408 1.0387841683410475 1.129995570449666 1.1595441573929872 0.9705190071386656 1.150740428873818 1.0489875186422055 1.4776008219774124 1.5224644886730443 1.0 12.744288003726135 -7.751460066424603 24.987164695779406 1.375024491680525 1.064901227093708 0.4031090651301986 0.15035542806298566 163.7449325937979 410002.9400701195 0.06865793490719603 0.03903861975155994 1.7723110024468206e-08 7.751460066424603 -0.31012326458681705 FTGS(ph)FDDDPDPHRDPYGEEVDRR ddPTM_A459_Selumetinib_30min_R1 1 FTGSFDDDPDPHRDPYGEEVDRR 23 2 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 1 FT(0.23)GS(0.767)FDDDPDPHRDPY(0.003)GEEVDRR 76.237 0.00033522 15208000.0 560.36 820.89 471.4 686.43 512.58 470.63 636.82 584.89 456.5 399.34 True False 573.4152977292463 724.7798171785928 407.38646921484974 566.5578863869467 466.2172295033494 465.8958894978502 588.7841546932766 569.3768172095249 774.6471585591659 450.5991789010016 1.2725617901208557 1.6084801107412354 0.9040994486684454 1.2573433617184235 1.034660628189425 1.0339474888395421 1.3066693910301928 1.263599322569159 1.7191490682439945 1.0 8.815700874416569 -10.332507321301545 11.066702960534773 1.0000072939600084 1.2532450465329483 0.09954483541030268 0.2375674699935199 0.0 0.0 0.23195844388555914 0.05625818700854546 4.6504253645074326e-11 10.332507321301545 0.2532377525729399 FTGSFDDDPDPHRDPYGEEVDRR ddPTM_A459_Selumetinib_30min_R2 1 FTGSFDDDPDPHRDPYGEEVDRR 23 2 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 0 45.424 0.03795 12634000.0 20462.0 18573.0 16756.0 17035.0 21609.0 16032.0 12394.0 17103.0 12564.0 19026.0 False True 19324.803955875996 19997.489378392303 15677.937202553396 14714.803612985903 18894.28423308894 18240.26247599401 12970.34555824508 17152.766898445927 15077.151067491046 18476.669944515328 1.0459029691988642 1.0823102560387738 0.848526127794326 0.7963991161380187 1.0226022486642719 0.9872050824509374 0.7019850220410111 0.9283473131227095 0.8160101962511158 1.0 14.173417142394129 -5.258189298769661 24.990242933413136 0.8835630018971605 1.0641066301594446 0.349096801682636 0.09625934893265682 297.0600969128615 2284102.32709348 0.024926357758191475 0.060425009455859664 5.518368541214339e-06 5.258189298769661 0.1805436282622841 FTGVAS(ph)GSTGSTGSCSVGAK ddPTM_A459_Selumetinib_30min_R2 1 FTGVASGSTGSTGSCSVGAK 20 0 B3KRP1;Q9UKI8;Q9UKI8-2;F8W7X8;Q9UKI8-5 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 FTGVAS(0.734)GS(0.239)T(0.021)GS(0.004)T(0.002)GSCSVGAK 284.07 6.853299999999996e-153 0.0 22722.0 22276.0 26121.0 26680.0 21246.0 15900.0 20747.0 17783.0 15611.0 18538.0 True False 21459.20220337282 23984.497571370644 24440.403298394438 23046.137974432862 18576.887538350114 18090.080674170713 21711.776609400596 17834.74558586587 18733.636207784344 18002.759772491583 1.1919951426648885 1.3322678230711729 1.357592036290994 1.2801447259018375 1.0318910974269515 1.0048504175350135 1.2060249030582761 0.9906673094153907 1.0405980218882633 1.0 14.135930464154113 -6.238900900600242 6.734697409567465 1.0510089968456313 1.2992918061993581 0.7447079601054254 0.07012454722813813 0.0930481796025068 18.01232229287665 0.021170068613917827 0.026679099608405903 5.768980877494652e-07 6.238900900600242 0.24828280935372682 FTGVASGS(ph)TGSTGSCSVGAK ddPTM_A459_Selumetinib_30min_R2 3 FTGVASGSTGSTGSCSVGAK 20 0 B3KRP1;Q9UKI8;Q9UKI8-2;F8W7X8;Q9UKI8-5 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 FT(0.003)GVAS(0.101)GS(0.789)T(0.056)GS(0.041)T(0.01)GSCSVGAK;FTGVAS(0.002)GS(0.865)T(0.09)GS(0.01)T(0.032)GSCSVGAK;FTGVASGS(0.474)T(0.474)GS(0.042)T(0.01)GSCSVGAK 224.4 3.7792999999999996e-42 6887200.0 42705.0 44121.5 56357.0 56480.0 47775.0 31975.5 41377.0 42467.3 37366.6 35683.5 True False 40331.6270616599 47505.477177017 52731.05197686209 48787.326566565534 41773.07738608099 36379.83488031105 43301.11248697006 42590.87281216001 44840.96411003746 34653.224638132684 1.1638636081583777 1.3708818637542202 1.5216780697181185 1.4078726316534356 1.205460035026973 1.0498253845120777 1.2495550685150718 1.229059438390408 1.293991095440339 1.0 15.080701987409293 -6.312940068734975 5.936959872880167 1.1793041224794818 1.3774651638103985 0.39702897206816257 0.11717002608596348 0.23104737757000954 19.19997848999389 0.03758685576246063 0.0431186339392498 4.864743329791301e-07 6.312940068734975 0.19816104133091672 FTGVASGST(ph)GSTGSCSVGAK ddPTM_A459_Selumetinib_30min_R2 1 FTGVASGSTGSTGSCSVGAK 20 0 B3KRP1;Q9UKI8;Q9UKI8-2;F8W7X8;Q9UKI8-5 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 FTGVAS(0.004)GS(0.177)T(0.603)GS(0.205)T(0.01)GSCSVGAK 269.34 1.5338999999999995e-58 5337100.0 24010.0 22380.0 25461.0 27922.0 23165.0 19190.0 18287.0 18302.0 15670.0 18835.0 True False 22675.620319645335 24096.47403695795 23822.86697984075 24118.97543186338 20254.80560227244 21833.248310524275 19137.381735003055 18355.255789940784 18804.437856382083 18291.184610792923 1.2397021189248358 1.3173818180556522 1.3024234070538983 1.3186119950717516 1.1073534072976805 1.1936486769501695 1.0462625653950715 1.0035028447042218 1.028060142440764 1.0 14.158860892403888 -6.848653982218157 0.9282778208100547 1.0020857027872008 1.3017809759837073 0.8624990129048603 0.04700943309202712 0.19001735370341574 0.34974411983344067 0.029401669233712735 0.024766123890425207 1.4169222424446968e-07 6.848653982218157 0.2996952731965066 FTIGDHSR ddPTM_A459_Selumetinib_30min_R1 2 FTIGDHSR 8 0 D6RD66;O75083 D6RD66 WDR1 WD repeat-containing protein 1 0 ; 129.42 0.0057317 18291700.0 11779.9 12620.2 11979.900000000001 12729.8 14248.1 12012.2 12885.8 12130.1 5958.700000000001 9710.9 False True 12054.348750304709 11142.621117028191 10353.09538088032 10506.779397940878 12959.361870706369 11891.368174204956 11913.813731582897 11808.370343882205 10111.478693771094 10957.388607176183 1.1001114574333988 1.0169048042825366 0.9448506165145864 0.9588762226667591 1.1827053265427732 1.0852374229400876 1.0872858633288167 1.0776628234348373 0.9228000444511855 1.0 13.4196163920473 -4.74977043332226 23.57132547082657 1.0364246156805867 1.100111756177912 0.06611056210251498 0.07555532105063588 887.3681819653619 1792247.1400098393 0.019991995596566853 0.2916198177184544 1.7792196513447657e-05 4.74977043332226 0.06368714049732516 FTIGDHSR ddPTM_A459_Selumetinib_30min_R2 4 FTIGDHSR 8 0 D6RD66;O75083 D6RD66 WDR1 WD repeat-containing protein 1 0 ;;; 140.35 0.0031056 15145200.0 158517.0 145324.0 178605.0 208755.0 212790.0 149774.0 148763.0 168457.0 140639.0 167523.0 False True 149707.25973382854 156469.88350969055 167113.74875042064 180322.20887753848 186057.41783326372 170404.00898699643 155680.77426829212 168947.1819804425 168770.7297819864 162686.17571297372 0.9202211501852265 0.9617896715806354 1.0272154226875334 1.1084052353389873 1.1436584394332543 1.0474400067504153 0.9569391719119319 1.0384851769981676 1.0374005599575198 1.0 17.311732137385206 -5.19913937227273 2.770235062347732 1.0501972858583277 0.9276770382138385 0.43096119244708786 0.048948110310831086 0.2897600605256329 4.244685889785819 0.014750394202234264 0.051287512988158215 6.322089325289559e-06 5.19913937227273 -0.12252024764448921 FTPPAES(ph)GSPSKETLPPPAAPPKPGK ddPTM_A459_Selumetinib_30min_R1 1 FTPPAESGSPSKETLPPPAAPPKPGK 26 2 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 FT(0.024)PPAES(0.347)GS(0.347)PS(0.142)KET(0.141)LPPPAAPPKPGK 65.248 0.00065305 31280000.0 2301.3 2908.5 3114.4 3859.8 2510.3 2390.5 2655.2 2359.5 1535.3 2432.6 True False 2354.915812449703 2567.971467875034 2691.4815861746474 3185.758387419458 2283.243808229461 2366.4537404003395 2454.916126286215 2296.918395263853 2605.291966124615 2744.8479055305697 0.8579403644569172 0.9355605688391152 0.9805576406443522 1.1606320266418046 0.8318288979250812 0.8621438498039155 0.8943723699006514 0.8368108085828044 0.9491571321220514 1.0 11.422510495088927 FTPPAES(ph)GSPSKETLPPPAAPPKPGK ddPTM_A459_Selumetinib_30min_R2 1 FTPPAESGSPSKETLPPPAAPPKPGK 26 2 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 FT(0.015)PPAES(0.259)GS(0.259)PS(0.259)KET(0.209)LPPPAAPPKPGK 49.106 0.015479 10940000.0 49102.0 48633.0 61995.0 57703.0 57963.0 41194.0 46453.0 52780.0 35291.0 57963.0 True False 46373.107410879835 52362.994720258044 58006.309195052345 49843.75185677284 50681.1697442054 46868.099578099886 48613.15654487323 52933.581061800636 42350.18611292792 56289.45758403982 0.8238329058624355 0.9302451465637311 1.0305004113505496 0.8854900010780247 0.9003669944507587 0.832626598117882 0.8636280865256888 0.9403817932118305 0.752364437864752 1.0 15.780577125737304 -5.970279032343717 24.99839359282748 0.8768452506736159 0.9333309142531692 0.06749604322148361 0.07669677916353511 484.9000106227128 407847.7279222598 0.02094622006567888 0.0310679377301124 1.0708310797899643e-06 5.970279032343717 0.056485663579553314 FTPPAESGSPSKET(ph)LPPPAAPPKPGK ddPTM_A459_Selumetinib_30min_R1 1 FTPPAESGSPSKETLPPPAAPPKPGK 26 2 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 FT(0.024)PPAES(0.077)GS(0.077)PS(0.301)KET(0.521)LPPPAAPPKPGK 68.291 0.0015105 21494000.0 2571.0 3315.1 3616.7 3821.7 2835.6 3099.4 2878.7 2809.5 1527.9 2572.1 True False 2630.8992977048556 2926.9665508518206 3125.572005111048 3154.311837193879 2579.12048066584 3068.222850030039 2661.5573413453344 2734.98293345785 2592.734706599234 2902.254089375639 0.9065020555353374 1.0085149200294512 1.0769463695659574 1.0868489594832356 0.8886611582725638 1.0571861579115234 0.9170655839847277 0.9423650890767548 0.8933520728217866 1.0 11.502958116070584 -7.279825399390558 24.54464233361801 0.9333927713796163 1.006134105721043 0.18895637043251412 0.06652409112505865 1081.7647171229182 1444108.0764378945 0.0280948815670656 0.01898031065119575 5.250184924598518e-08 7.279825399390558 0.0727413343414266 FTPPSTALS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 FTPPSTALSPGK 12 0 C9JWM1;A8MZI9;H9KVB1;Q01196-6;Q01196-5;Q01196-7;Q01196-3;Q01196-4;Q01196;Q01196-9;Q01196-10;Q01196-2;Q01196-8 C9JWM1 RUNX1 Runt-related transcription factor 1 1 FTPPS(0.062)T(0.011)ALS(0.927)PGK;FTPPST(0.002)ALS(0.997)PGK 129.54 0.0022951 9161900.0 54393.0 45485.0 47580.0 54590.0 48465.0 42434.0 46220.0 46156.0 37506.0 46974.0 True False 51370.054812431044 48973.55324267344 44518.754601187065 47154.747826997365 42376.393417402745 48278.89832250065 48369.32158319251 46290.30631846285 45008.24800519889 45617.73856689069 1.126098233412109 1.073563810508976 0.9759088459834072 1.0336932366310292 0.9289455099854399 1.0583360736242509 1.0603182687863206 1.0147435574998078 0.9866391763195782 1.0 15.477307308461686 -5.019233313387216 3.760164773949498 1.0098643278267685 1.1204562165942042 0.5151592206522448 0.037396766851196174 0.17709004351484275 5.381649494994548 0.009851756860564987 0.03894309245625176 9.566799818395233e-06 5.019233313387216 0.11059188876743575 FTPVASKFS(ph)PGAPGGSGSQPNQK ddPTM_A459_Selumetinib_30min_R1 2 FTPVASKFSPGAPGGSGSQPNQK 23 1 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 FT(0.001)PVAS(0.031)KFS(0.941)PGAPGGS(0.004)GS(0.022)QPNQK;FT(0.001)PVAS(0.124)KFS(0.785)PGAPGGS(0.079)GS(0.011)QPNQK 87.352 0.00012909 388380000.0 9255.5 10073.9 13651.8 14181.2 11949.2 8832.8 10165.7 8366.7 5678.2 6967.5 True False 9471.135141932047 8894.443104770951 11797.960543969644 11704.71963409316 10868.396969802607 8743.950051540724 9398.893064547976 8144.787937128235 9635.490680680514 7861.846494197251 1.2046960149784909 1.1313427591515364 1.5006602523564407 1.4888003273445107 1.3824229432391564 1.1122005572093712 1.1955070696795216 1.0359891843652531 1.225601477692597 1.0 12.94065247948204 -6.765536537327273 24.997051815344896 1.1212119074866906 1.346920580373738 0.4625155908126857 0.12254844245217562 107.24784344629452 654321.7773360735 0.04589994993978011 0.041939198270250125 1.7157873543350947e-07 6.765536537327273 0.22570867288704743 FTPVASKFS(ph)PGAPGGSGSQPNQK ddPTM_A459_Selumetinib_30min_R2 2 FTPVASKFSPGAPGGSGSQPNQK 23 1 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 FTPVAS(0.003)KFS(0.961)PGAPGGS(0.008)GS(0.028)QPNQK;FT(0.021)PVAS(0.147)KFS(0.703)PGAPGGS(0.022)GS(0.107)QPNQK 96.455 3.9437e-05 294700000.0 99129.0 109288.0 126423.0 135219.0 131299.0 97049.0 98202.0 91415.0 76521.0 146658.0 True False 93619.8070248281 117670.03818369367 118289.08181895487 116801.93893421422 114804.04579204718 110416.61882689265 102768.58758357131 91681.00251543197 91827.33817538075 142423.6024767544 0.6573335135242644 0.8261975974305181 0.8305440935484086 0.8201024051001519 0.8060745817097617 0.7752691050271266 0.721569920971102 0.6437205696323799 0.6447480373933688 1.0 17.119828724354363 -7.157455193983798 3.861081473057079 0.7228706588285279 0.7939227447180497 0.0 0.10539943697604956 0.6222148400696023 16.627337030472077 0.040740842050987706 0.030766567336134185 6.9589674643137e-08 7.157455193983798 0.07105208588952183 FTQQNYHDR ddPTM_A459_Selumetinib_30min_R1 2 FTQQNYHDR 9 0 Q9BZE4-2;Q9BZE4;Q5T3R7 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 0 ; 134.57 0.0040072 1952200.0 1689.27 2895.3 2562.6 2662.6000000000004 2084.79 2367.1000000000004 1951.9099999999999 1532.12 1241.1799999999998 1507.81 False True 1728.6267042527743 2556.316930011546 2214.6129953542086 2197.626893192145 1896.221112599569 2343.289123154839 1804.6758572082426 1491.483200572856 2106.191807799487 1701.3521008131397 1.0160311339590429 1.5025208061222521 1.3016782324456897 1.2916943483608225 1.1145377324854122 1.377309918408361 1.0607303781185098 0.876645815913132 1.237951748372873 1.0 10.732466027385824 -7.35839965812933 6.440326652820036 1.0299119348592956 1.2732917186945758 0.34780060769423105 0.14964748457805638 0.26090951358511894 14.625427749258273 0.06069895412603107 0.04062459110054203 4.381273269101904e-08 7.35839965812933 0.24337978383528025 FTS(ph)QDASTPASSELNK ddPTM_A459_Selumetinib_30min_R2 1 FTSQDASTPASSELNK 16 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 FT(0.125)S(0.867)QDAS(0.007)T(0.001)PASSELNK 117.2 0.0018609 5411600.0 21623.0 19824.0 19654.0 24236.0 27401.0 27066.0 23524.0 23658.0 21533.0 23684.0 True False 20421.280223727255 21344.43705579332 18389.483037657217 20935.014990568023 23958.64141195198 30794.09581931475 24617.91261192169 23726.840863207253 25840.201682289462 23000.18138157789 0.8878747469393341 0.9280116839812947 0.7995364354989984 0.9102108650037006 1.0416718466029913 1.3388631727912994 1.0703355857723595 1.031593641353254 1.1234781697411438 1.0 14.489357617991757 -6.319153555395249 3.6603699730279406 1.1179832612749274 0.8763904965301375 0.586862352459832 0.09135933884418568 0.16799569117299537 4.558128852352906 0.029834911998900912 0.03517957882778319 4.795638571710385e-07 6.319153555395249 -0.24159276474478997 FTSGAFLS(ph)PSVSVQECR ddPTM_A459_Selumetinib_30min_R1 1 FTSGAFLSPSVSVQECR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 FTSGAFLS(0.972)PS(0.026)VS(0.001)VQECR 152.94 0.0003677 0.0 1138.4 1306.7 1624.9 1356.1 1326.8 1095.3 1484.1 1212.3 808.38 1066.8 True False 1164.922505059202 1153.7109565316516 1404.2475049368056 1119.2825921497297 1206.7911742655656 1084.2822764528296 1372.1531421442346 1180.1458658946249 1371.7618182608078 1203.7341715119667 0.9677572778348439 0.9584433040415536 1.1665760914413366 0.9298420021954179 1.0025395995444402 0.9007655528221004 1.139913757221599 0.9804040574940949 1.13958866560861 1.0 10.233301112154432 -7.2689987525184945 24.997347497355847 1.0633436164350816 0.9925078395654847 0.17466480368020632 0.0819052594520659 1189.2936762727331 3932740.8000035477 0.032988317766492914 0.022739515264051772 5.3827132866202823e-08 7.2689987525184945 -0.07083577686959686 FTSGAFLS(ph)PSVSVQECR ddPTM_A459_Selumetinib_30min_R2 2 FTSGAFLSPSVSVQECR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 FTS(0.001)GAFLS(0.908)PS(0.088)VS(0.003)VQECR;FT(0.001)S(0.001)GAFLS(0.997)PS(0.001)VSVQECR 220.42 6.1077e-12 19590800.0 36516.0 35813.0 42503.0 43481.0 48028.0 36858.0 35264.0 36778.0 35186.0 41682.0 True False 34486.5869051299 38559.74194305519 39768.403253767436 37558.812791091295 41994.29326423227 41934.854936388954 36903.845874290375 36885.01789107434 42224.183178982785 40478.53235715797 0.8519722652205177 0.9525973324039384 0.9824566489435737 0.9278699252160418 1.0374460440833215 1.0359776527069033 0.9116893258054236 0.911224190779037 1.043125348676732 1.0 15.304869362283391 -4.697525621401913 2.312472474499542 0.9778675304182115 0.8015288094172051 0.3929764292304313 0.048002258478438 0.9162929002127173 4.792842459203799 0.013049524099444931 0.3593559785572435 2.006662702540661e-05 4.697525621401913 -0.17633872100100645 FTSSQTQS(ph)PTPPKPPS(ph)PSFELGLSSFPPLPGAAGNLK ddPTM_A459_Selumetinib_30min_R1 1 FTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLK 37 1 Q92615;H0Y4V9 Q92615 LARP4B La-related protein 4B 2 FT(0.026)S(0.029)S(0.028)QT(0.078)QS(0.66)PT(0.18)PPKPPS(0.396)PS(0.315)FELGLS(0.141)S(0.147)FPPLPGAAGNLK 64.752 3.3548000000000005e-05 4478800.0 1335.0 1296.0 1456.1 1886.5 1294.9 984.81 1000.3 1108.1 797.37 1052.2 True False 1366.1029025421944 1144.2637175059456 1258.3696177847755 1557.0581889908294 1177.7765236331632 974.9037055359364 924.8465656538498 1078.7095883839263 1353.078652399392 1187.2601192959232 1.150634878018416 0.9637851881898672 1.0598937817695941 1.3114718195994035 0.9920122006048817 0.8211374152060967 0.7789755173468712 0.9085705574138461 1.1396648724306546 1.0 10.213420337338295 -6.515481957417848 24.78682275617969 0.9136522465848196 1.1115325052976803 0.3474120380695722 0.12298814291873056 360.3614191609447 1207585.181730244 0.041635800429270994 0.043352470826517955 3.0515328011583995e-07 6.515481957417848 0.19788025871286075 FTSSQTQSPT(ph)PPKPPS(ph)PSFELGLSSFPPLPGAAGNLK ddPTM_A459_Selumetinib_30min_R1 1 FTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLK 37 1 Q92615;H0Y4V9 Q92615 LARP4B La-related protein 4B 2 FT(0.023)S(0.023)S(0.021)QT(0.02)QS(0.058)PT(0.822)PPKPPS(0.361)PS(0.361)FELGLS(0.155)S(0.155)FPPLPGAAGNLK 64.273 6.7579e-05 3034400.0 527.17 798.97 808.68 755.6 591.52 447.92 809.0 492.66 432.35 769.37 True False 539.4520353057443 705.4262209689236 698.8656977612743 623.6486443686567 538.0171204413382 443.41433147882026 747.9764786703632 479.5930564147867 733.6663724053785 868.1261337984272 0.6213982211840673 0.8125849384148579 0.8050278301189191 0.71838482921822 0.6197453336501698 0.5107717809838195 0.8615988501551528 0.5524462837172747 0.845114947980279 1.0 9.761760863072412 -8.524372878711933 8.201009032382661 0.9999932105500073 0.694601341573126 0.4550932116732881 0.10933242666638615 0.08344012991294557 85.95650670146829 0.10528668836598445 0.02721147189341081 2.9896966257696104e-09 8.524372878711933 -0.3053918689768813 FTVLFPSGT(ph)PLPAR ddPTM_A459_Selumetinib_30min_R1 1 FTVLFPSGTPLPAR 14 0 Q0VDF9 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 1 FTVLFPS(0.075)GT(0.925)PLPAR 105.58 0.017022 0.0 1395.2 1463.0 1429.8 1623.9 1474.7 1220.3 1500.1 1157.8 858.03 1296.3 True False 1427.7054454133847 1291.7112798697524 1235.6410133292163 1340.3163493783243 1341.313645379432 1208.0248899437486 1386.9462492625619 1127.091382935574 1456.0142419682825 1462.6927320312734 0.9760802211895173 0.8831050100836453 0.844771417995121 0.9163348665286644 0.917016688472035 0.825891086685129 0.948214357595446 0.7705592283694181 0.9954341127724643 1.0 10.514411018914396 -8.467342358151756 24.85046747756462 1.0000005348628953 0.8858513670734324 0.3837511662208609 0.05702063386509841 225.4110035976774 100863.09699764375 0.05127132591481278 0.013238199430210883 3.4092405224117778e-09 8.467342358151756 -0.11414916778946294 FTVQMPTSQS(ph)PAVK ddPTM_A459_Selumetinib_30min_R2 2 FTVQMPTSQSPAVK 14 0 Q16594 Q16594 TAF9 Transcription initiation factor TFIID subunit 9 1 FTVQMPT(0.047)S(0.264)QS(0.689)PAVK;FTVQMPT(0.023)S(0.023)QS(0.954)PAVK 127.2 0.0016312999999999998 5096200.0 46851.0 40232.0 46064.0 51051.0 48450.0 43151.0 46143.0 39386.0 30884.0 48703.0 True False 44247.2089794129 43317.66503373064 43100.29239069109 44097.76573211294 42363.27785150442 49094.658564222664 48288.74093061992 39500.60673929671 37061.662971059624 47296.817844409175 0.9355219018110589 0.9158684877327556 0.911272562405292 0.9323622125526487 0.8956898113286508 1.0380118748311522 1.0209723007047502 0.8351641514074073 0.7835973890036363 1.0 15.529455501073418 -7.783707682415396 24.999767780993125 0.8570355361964962 0.9477808780441975 0.20501780101177502 0.06727685208632217 337.98465292363176 379436.75751132966 0.03714201508549918 0.01786389142433544 1.6454788995567026e-08 7.783707682415396 0.09074534184770133 FVAFSGEGQS(ph)LR ddPTM_A459_Selumetinib_30min_R1 3 FVAFSGEGQSLR 12 0 Q92890;Q92890-1 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 FVAFS(0.001)GEGQS(0.999)LR;FVAFSGEGQS(1)LR;FVAFSGEGQS(1)LR 142.39 0.00091249 19247300.0 4154.75 4624.889999999999 6120.400000000001 7736.1 5289.0 3982.07 4023.12 3761.2700000000004 2146.92 3242.24 True False 4251.5475912638085 4083.40572874697 5289.283296950716 6385.13535958227 4810.610883848792 3942.0139912302734 3719.6528193675067 3661.50890127318 3643.166435167241 3658.413086092012 1.1621289043128245 1.1161685770998988 1.445786239137044 1.745329247770376 1.3149446961408013 1.0775201975458735 1.0167394254925193 1.0008462180481852 0.9958324413985034 1.0 11.837002269428645 -6.781420564508066 3.7359463104659403 1.0102799884427194 1.374118985312043 0.5325345331111357 0.1600310089272526 0.20328444599960757 6.080900047147862 0.06517556323213804 0.06001216762704602 1.6541673158504278e-07 6.781420564508066 0.36383899686932364 FVAFSGEGQS(ph)LR ddPTM_A459_Selumetinib_30min_R2 4 FVAFSGEGQSLR 12 0 Q92890;Q92890-1 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 FVAFSGEGQS(1)LR;FVAFSGEGQS(1)LR;FVAFSGEGQS(1)LR;FVAFS(0.009)GEGQS(0.991)LR 140.45 0.0010735 14204400.0 42273.8 51623.1 52279.5 54370.0 52420.8 24552.0 26218.300000000003 36462.9 36780.2 41078.1 True False 39924.39143142952 55582.42577557118 48915.89388761578 46964.71220651855 45835.23045610202 27933.81513913456 27437.502900575862 36569.00100224197 44137.26772465249 39892.06851927861 1.000810259115425 1.3933202222569607 1.2262060029295354 1.1772944835844235 1.1489810420322342 0.7002348129838142 0.6877934366155056 0.9166985408282173 1.1064171240787453 1.0 15.283814312829955 -6.6340352330995 6.333290379108318 0.8660106239720486 1.2086634272504142 0.5208712598117079 0.14721009199855478 0.16888264108886927 8.794477934349763 0.050825395242805646 0.050722007103307175 2.322548366845463e-07 6.6340352330995 0.34265280327836556 FVCVGGSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 FVCVGGSPSR 10 0 F8WD51;C9J486;C9JIP2;B4DND0;Q16831 F8WD51 UPP1 Uridine phosphorylase 1 1 FVCVGGS(0.371)PS(0.629)R 112.83 0.0079968 4669500.0 17949.0 16580.0 17183.0 18871.0 19883.0 14982.0 16399.0 14300.0 12429.0 19193.0 True False 16951.46643553996 17851.63268689734 16077.464487435847 16300.737245709246 17385.119783724713 17045.634506945007 17161.585994002035 14341.610632507562 14915.147295275889 18638.848220597207 0.9094696321850737 0.9577647972458975 0.8625782182006904 0.8745571106532115 0.9327357344169455 0.9145218795283934 0.9207428372659477 0.7694472567601628 0.8002182923939274 1.0 14.186025091592473 -7.7213978653593225 24.999998544456282 0.8386243075196198 0.9099719011851751 0.11650876430398205 0.06224331893009944 219.5603291104132 137082.79422155023 0.02809289236435578 0.01621914758216851 1.8993374638034705e-08 7.7213978653593225 0.07134759366555532 FVHGPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 FVHGPSPR 8 0 Q5T200;Q5T9K0;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 FVHGPS(1)PR;FVHGPS(1)PR;FVHGPS(1)PR 84.81700000000002 0.023908 13128300.0 9349.599999999999 11430.6 11923.4 12443.9 11213.0 9921.5 9832.900000000001 9405.1 5498.4 8400.0 True False 9567.427488845316 10092.30003805823 10304.267770548031 10270.806465933196 10198.786129815946 9821.698718001235 9091.196436486798 9155.646195929668 9330.383212752946 9478.221822928874 1.0094116457266957 1.0647883354706718 1.0871519957067115 1.0836216600340554 1.076023152902367 1.0362385373004726 0.9591668781684537 0.9659666514431158 0.9844022842113391 1.0 13.210400710044354 -7.090453052208419 3.7504686030109213 0.9749131512957129 1.066115090511144 0.7627932955695031 0.02280211426482269 0.11547683256566273 2.999417937489254 0.009512344247364057 0.0073525722181729545 8.119830205994347e-08 7.090453052208419 0.09120193921543118 FVHGPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 FVHGPSPR 8 0 Q5T200;Q5T9K0;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 FVHGPS(1)PR;FVHGPS(1)PR;FVHGPS(1)PR 80.706 0.030097 30343100.0 265398.0 239338.0 286359.0 287028.0 277217.0 210901.0 237190.0 226903.0 200284.0 265372.0 True False 250648.2416323715 257694.45500703505 267934.9737041049 247934.2912490825 242390.52210857568 239950.69838133818 248219.80498306858 227563.25016418617 240346.39640252877 257710.02084073998 0.9725979642338684 0.9999395994239799 1.0396761943133122 0.962066940355033 0.9405552850363104 0.9310879631243493 0.9631748279453356 0.8830205725869544 0.9326234021418143 1.0 17.975389110726944 -5.9681499511762 5.6994749047890485 0.9375506591806846 1.003808924348687 0.4358740243187076 0.03146009583418934 0.15438534271954857 14.026417700851056 0.00890370362917583 0.013112280262552815 1.0760936008920253e-06 5.9681499511762 0.06625826516800237 FVINYDYPNSSEDYIHR ddPTM_A459_Selumetinib_30min_R1 1 FVINYDYPNSSEDYIHR 17 0 P17844-2;P17844;J3KTA4 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 0 118.5 0.0021663 18326000.0 2726.1 2816.2 2968.1 3316.1 3180.0 2635.7 2629.0 2615.1 1729.7 2118.8 False True 2789.612825932792 2486.4779947841384 2565.048322606271 2737.005385906435 2892.369561474601 2609.187251024124 2430.692413379957 2545.739052958043 2935.1745677103827 2390.768618859727 1.1668267702389756 1.0400328894939486 1.0728969346392316 1.1448223656255974 1.2098073977790924 1.0913591681107857 1.0166991461261825 1.0648203397333484 1.2277116842491889 1.0 11.223258795900893 -9.56262935589267 10.127100829446157 0.999999873357808 1.1101578920442283 0.2040259353401247 0.06753608171143068 0.0 0.0 0.06758894641314334 0.01639272736385894 2.737604109356822e-10 9.56262935589267 0.11015801868642028 FVLMAT(ph)PNLSR ddPTM_A459_Selumetinib_30min_R2 1 FVLMATPNLSR 11 0 E7EUN2;A0A087X1U1;F5GXM9;Q9UPQ3-2;Q9UPQ3 E7EUN2 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 1 FVLMAT(0.997)PNLS(0.003)R 113.07 0.017095 17227000.0 39380.0 43740.0 34060.0 44125.0 35094.0 29611.0 34881.0 36225.0 27182.0 30201.0 True False 37191.41725063031 47094.71735373283 31868.616681724063 38115.09888012934 30685.17797565938 33689.64646810498 36503.03561539026 36330.4087526284 32619.1595285372 29329.018658378376 1.268075747226063 1.605737917871976 1.0865899419590777 1.299569526143728 1.0462395054221696 1.148679635705469 1.2446047391006891 1.2387188666556337 1.112180394048709 1.0 14.840041179237007 -1.5228787452970078 0.26601082276834737 1.0957039974827727 3.3741000120812537 0.3145412276501989 0.13585444480205328 61.21396692130042 0.8510532208055193 0.15836584450671343 63.70934484920741 0.029999999998848458 1.5228787452970078 2.278396014598481 FVNDYDKDNDGR ddPTM_A459_Selumetinib_30min_R2 1 FVNDYDKDNDGR 12 1 A8MXP8;Q14257;Q14257-2 A8MXP8 RCN2 Reticulocalbin-2 0 100.09 0.038808 5847500.0 24792.0 16472.0 28023.0 28952.0 25773.0 22781.0 26269.0 31638.0 29460.0 22910.0 False True 23414.159890239374 17735.349434172083 26220.030689135463 25008.687655014277 22535.165326456616 25918.875964671875 27490.560551036 31730.06134204714 35352.82318117528 22248.528772671383 1.0523913796493265 0.7971470660099111 1.1785062714502907 1.1240602877855586 1.012883393626338 1.1649703326230227 1.2356125131655258 1.426164474345928 1.5889959980005663 1.0 14.44142231776117 -7.2261758392295805 1.7150311840206611 1.3734461166700318 1.0316627393744844 0.37643008626102537 0.16801588076358573 0.3561960584341728 2.0492692228174567 0.08857988802712263 0.05602844876042797 5.940515874655348e-08 7.2261758392295805 -0.3417833772955474 FVQSTQNNGT(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 FVQSTQNNGTLK 12 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 FVQSTQNNGT(1)LK 165.78 0.0011625 2735700.0 11240.0 6689.2 8869.0 11456.0 11542.0 5444.1 10552.0 8385.8 5881.2 7665.6 True False 10615.325797285032 7202.240130831948 8298.378195837073 9895.673037297713 10091.990773210815 6193.975358380675 11042.688908391325 8410.201289656075 7057.604334457843 7444.274210379306 1.4259718942760642 0.9674872159854216 1.114733009736116 1.3292999099227836 1.3556715521225542 0.8320455672823845 1.4833801921206593 1.1297543658359614 0.9480580826291511 1.0 12.86191548281416 -8.122956438663126 4.888047693181201 0.9795620596273905 1.2036422149928958 0.19429757176511975 0.19258806591937694 0.38463872158260964 13.32414015936598 0.1342091864276199 0.04817548728617922 7.534311318626307e-09 8.122956438663126 0.2240801553655053 FVS(ph)EGDGGR ddPTM_A459_Selumetinib_30min_R1 2 FVSEGDGGR 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 1 FVS(1)EGDGGR;FVS(1)EGDGGR 90.149 0.028927 97244000.0 8846.7 10082.7 10175.5 11092.1 11249.2 8387.0 11658.7 11568.900000000001 5826.9 9301.2 True False 9052.810897318377 8902.212796679936 8793.72299002059 9155.072959504465 10231.711846207574 8302.634394786712 10779.27487252678 11262.055190916713 9887.82372006222 10495.099621360243 0.8625750325317126 0.8482256593888475 0.8378884724565251 0.8723188240034924 0.9749037374912949 0.7910962920150565 1.0270769465197038 1.0730774930421354 0.9421371951475278 1.0 13.357428240563534 -7.278208294154836 24.881037332184714 1.01666271713574 0.8679254887335358 0.6470963042202087 0.05273337987030808 487.6025695796676 723482.0405873972 0.02176089677320243 0.014716067787335493 5.2697705469426025e-08 7.278208294154836 -0.14873722840220427 FVS(ph)EGDGGR ddPTM_A459_Selumetinib_30min_R2 3 FVSEGDGGR 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 1 FVS(1)EGDGGR;FVS(1)EGDGGR;FVS(1)EGDGGR 109.83 0.011204 129066000.0 204760.0 189845.0 212467.0 229507.0 238418.0 185374.0 177856.0 203808.0 199073.0 240876.0 True False 193380.25891922446 204405.50105211246 198797.1045365785 198247.75067834195 208465.79935603688 210907.5858423722 186126.65641497818 204401.0475377693 238893.16256436164 233921.28400899205 0.8266894555511709 0.8738217298954934 0.8498461582013915 0.8474977021360793 0.8911792710064953 0.9016177674292555 0.7956807231266027 0.8738026913784896 1.0212544941193913 1.0 17.83566360990752 -8.229336492725874 5.58677531811785 1.0115928879399825 0.8573884653436159 0.8129048761312825 0.02942472215481453 0.06823839554007677 6.403897418644623 0.022038749048771424 0.007548117987735071 5.897439676339238e-09 8.229336492725874 -0.15420442259636657 FVS(ph)FTSR ddPTM_A459_Selumetinib_30min_R1 2 FVSFTSR 7 0 Q8N5V2;Q8N5V2-3 Q8N5V2 NGEF Ephexin-1 1 FVS(0.878)FT(0.121)SR;FVS(0.997)FT(0.002)SR 88.177 0.03262 8239800.0 5831.2 4380.9 4453.6 3726.9 4006.2 3420.0 4431.6 4710.8 1884.5300000000002 3530.5 True False 5967.055614459955 3867.982191374843 3848.8255818736893 3076.0668775774825 3643.8399173520547 3385.59790511155 4097.320844098373 4585.854281165056 3197.9097693746007 3983.6740649821895 1.4978774661592784 0.9709584991843795 0.9661497198543769 0.7721683118147457 0.9146932851215441 0.8498681995276857 1.028528131885883 1.151162019372074 0.8027538692196944 1.0 11.959883898918061 -4.759232322863293 4.83380848552422 0.9365722976875754 1.538465937493908 0.714825735708595 0.10599331507876708 0.10393988013443975 6.000915380372644 0.027369135297637157 0.21535084631043108 1.74087535489249e-05 4.759232322863293 0.6018936398063326 FVSEDDRNS(ph)FTLK ddPTM_A459_Selumetinib_30min_R2 2 FVSEDDRNSFTLK 13 1 A0A087WYC1;P34932 A0A087WYC1 HSPA4 Heat shock 70 kDa protein 4 1 FVSEDDRNS(0.989)FT(0.01)LK;FVS(0.024)EDDRNS(0.976)FTLK 163.8 0.0017227 10309100.0 53138.0 48715.0 45897.0 59760.0 53338.0 41444.0 42019.0 41015.0 36800.0 47088.0 True False 50184.80268826795 52451.283856586524 42944.03698887521 51620.58490824994 46637.20359222998 47152.534808825876 43972.96675906891 41134.34685960124 44161.02827791072 45728.44709068314 1.0974525898232996 1.1470165114632356 0.9391098915673601 1.1288505994065843 1.0198728922446174 1.0311422715780978 0.9616107599688882 0.8995351794481139 0.9657233317006347 1.0 15.480804306509528 -7.010280502959947 1.5546535908812298 0.9460230568041949 1.0718656973902878 0.43867528117664056 0.05894839369001168 0.35566516194149456 1.7379803067185893 0.02902356951193435 0.021475542084131632 9.766062448794096e-08 7.010280502959947 0.12584264058609296 FVYS(ph)LLWPR ddPTM_A459_Selumetinib_30min_R1 3 FVYSLLWPR 9 0 C9JFR9;Q9UNU6 C9JFR9 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase 1 FVY(0.366)S(0.634)LLWPR;FVY(0.342)S(0.658)LLWPR;FVY(0.342)S(0.658)LLWPR 100.19 0.018138 277920000.0 7815.0 8172.6 8541.9 9244.1 8350.1 7131.0 7343.6 7038.400000000001 4560.5 6659.7 True False 7997.074294657117 7215.748192661342 7381.956897298105 7629.791468248151 7594.834929329892 7059.268614429958 6789.66633963372 6851.718768054719 7738.835414258653 7514.5373659713605 1.0642137905749014 0.9602385138620712 0.982356802259893 1.0153374847530474 1.0106856296599374 0.9394149327671149 0.9035375045681284 0.9117951557579402 1.0298485505312673 1.0 12.875468571722692 -6.760742298413419 24.996354370875014 0.9480700634042255 1.003134975248186 0.23144488110785 0.04355082593066353 25.701267794544076 921630.711690438 0.014793662644575413 0.013979872089624118 1.7348331073747816e-07 6.760742298413419 0.05506491184396045 FWEGDFHR ddPTM_A459_Selumetinib_30min_R1 2 FWEGDFHR 8 0 P49589-3;B4DKY1;P49589-2;P49589 P49589-3 CARS Cysteine--tRNA ligase, cytoplasmic 0 ; 136.27 0.0036669 5893200.0 3683.9 4539.3 4878.2 5869.6 4912.5 4365.6 4507.7 3959.6000000000004 2604.5 3479.2 False True 3769.727702378421 4007.836645736683 4215.76723403454 4844.584546037939 4468.165242372319 4321.686027647653 4167.680559829909 3854.578545406547 4419.6462748463255 3925.7892102778724 0.9602470994899889 1.0208996028732278 1.0738648990622046 1.2340409243967108 1.138157196691683 1.1008451539714121 1.0616159800222476 0.9818608027438425 1.1257981613672776 1.0 11.938766996067574 -10.520980878496223 14.730865802894076 1.00000328429353 1.0795080594593278 0.08540621573414509 0.07580452430932538 0.0 0.0 0.07969026053756081 0.019327727148785535 3.013138686416045e-11 10.520980878496223 0.07950477516579779 FWEVISDEHGIDPTGTYHGDS(ph)DLQLER ddPTM_A459_Selumetinib_30min_R1 2 FWEVISDEHGIDPTGTYHGDSDLQLER 27 0 P04350;M0QY85;M0R2D3;M0QZL7;M0QYM7;M0R278;M0R0X0;M0QY37;M0QX14;P68371 P04350;P68371 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 1 FWEVISDEHGIDPTGT(0.001)Y(0.012)HGDS(0.987)DLQLER;FWEVISDEHGIDPTGT(0.001)Y(0.004)HGDS(0.995)DLQLER 133.68 2.7272e-12 18640400.0 5149.5 5388.5 5819.6 6294.7 7294.3 4879.7 5676.8 5242.5 1924.76 3653.0 True False 5269.473330817247 4757.611914954314 5029.33028477459 5195.448811153235 6634.531852913259 4830.614648413104 5248.594405582101 5103.451869960055 3266.1771410916544 4121.898133233232 1.2784094027777082 1.1542284067128135 1.220149096899094 1.2604505602077811 1.6095817117414077 1.1719393571291272 1.2733440361528499 1.2381314882124193 0.7923963755333402 1.0 12.009093135852886 -8.193736018693636 6.054911374772945 0.8980755802556712 1.2788037911265848 0.5865630381705247 0.12760113068379567 0.14499737957279335 9.93561899554195 0.09207337804384784 0.03346569699030252 6.401238097395205e-09 8.193736018693636 0.3807282108709136 FWEVISDEHGIDPTGTYHGDSDLQLDR ddPTM_A459_Selumetinib_30min_R1 2 FWEVISDEHGIDPTGTYHGDSDLQLDR 27 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 ; 133.15 3.0295e-12 46774000.0 1715.11 2257.45 2480.81 2703.7200000000003 2707.49 1874.96 2460.96 2115.34 1099.63 1399.96 False True 1755.0687259768858 1993.1467045399672 2143.929628113899 2231.5660571101434 2462.5980075461835 1856.0996047274712 2275.3278058697374 2059.2343116073043 1865.9917962024435 1579.6585027651786 1.111043129198275 1.261757969238909 1.357210830290831 1.4126889154863576 1.5589432799781895 1.1750005469399778 1.4403922125489754 1.3035946111153978 1.1812627811239207 1.0 10.62539698887602 -8.524198397357944 2.1342634180108258 1.0017503833976846 1.337064614153412 0.4144406438097419 0.12236615316384385 0.31869062218628763 3.3460577081125766 0.11995657224764603 0.033252304191197075 2.990898002114209e-09 8.524198397357944 0.3353142307557273 FY(ph)IESIS(ph)Y(ph)LK ddPTM_A459_Selumetinib_30min_R1 1 FYIESISYLK 10 0 Q9P2Q2;A0A1W2PQE7;Q5T376 Q9P2Q2 FRMD4A FERM domain-containing protein 4A 3 FY(1)IES(0.191)IS(0.826)Y(0.984)LK 81.625 0.041851 0.0 1241.8 1362.3 1193.4 1251.5 1207.7 1383.9 1492.0 1064.5 710.55 1255.6 True False 1270.7315238778253 1202.8012826839117 1031.342834876967 1032.9490185645498 1098.4637482367525 1369.979222480664 1379.457238783908 1036.2660020166866 1205.751453481305 1416.7684905797007 0.8969224910965367 0.848975178853505 0.72795438473859 0.7290880799740943 0.7753304478047031 0.9669746550617512 0.9736645386710103 0.7314293117802729 0.851057502689057 1.0 10.46838831618562 -6.738179933626173 24.96999838689753 0.8921545126304348 0.7911571582720791 0.2801544916706987 0.08603547780324952 364.0199032721712 390789.9200641949 0.03048546902787293 0.030467561934817783 1.8273429682781686e-07 6.738179933626173 -0.10099735435835566 FYCDYCDTYLTHDS(ph)PSVR ddPTM_A459_Selumetinib_30min_R1 2 FYCDYCDTYLTHDSPSVR 18 0 A0A0A0MRR7;P09234 A0A0A0MRR7 SNRPC U1 small nuclear ribonucleoprotein C 1 FYCDYCDT(0.03)Y(0.022)LT(0.18)HDS(0.754)PS(0.015)VR;FYCDYCDT(0.007)YLT(0.043)HDS(0.93)PS(0.02)VR 203.2 5.8851e-11 60103000.0 4277.299999999999 5366.6 4725.2 5083.9 5240.5 4243.1 5369.200000000001 4643.4 2365.4 4527.3 True False 4376.952767823016 4738.275977135345 4083.5437936656986 4196.092301622305 4766.497700285422 4200.418266426555 4964.19692123228 4520.241948111115 4013.9110380193915 5108.423054636413 0.8568109416565424 0.9275418121126201 0.7993746308774226 0.8214065782617446 0.9330663590908629 0.8222534080481546 0.9717669950468896 0.8848605332341329 0.7857436620047275 1.0 12.31866229160418 -6.254613850750777 24.94229760169624 0.8935976905291385 0.8530227402030562 0.1062410348125703 0.06725596563278789 1505.098242377037 5500020.59845636 0.019748293403423097 0.024935393348893335 5.563987546247934e-07 6.254613850750777 -0.04057495032608227 FYCDYCDTYLTHDS(ph)PSVR ddPTM_A459_Selumetinib_30min_R2 2 FYCDYCDTYLTHDSPSVR 18 0 A0A0A0MRR7;P09234 A0A0A0MRR7 SNRPC U1 small nuclear ribonucleoprotein C 1 FYCDYCDTYLTHDS(0.93)PS(0.07)VR;FYCDYCDTYLTHDS(0.853)PS(0.147)VR 147.75 0.00014003 10544400.0 43353.0 44234.0 47112.0 47617.0 48440.0 32906.0 42027.0 41160.0 30320.0 49749.0 True False 40943.613815809425 47626.60556527247 44080.86521166719 41131.482456093356 42354.534140905555 37438.50280907304 43981.33877492063 41279.76878559518 36384.847211582965 48312.61710657485 0.8474724878904857 0.9858005717266551 0.9124089699886748 0.8513610919764433 0.8766764600533623 0.7749218537775725 0.9103489193702823 0.8544304005418375 0.7531127351540507 1.0 15.560112385588125 -5.7201553394925275 5.051662006791747 0.8531335701166886 0.9238176781765176 0.10328670566455378 0.07157962758418383 0.3448509397005129 20.159880752990897 0.018736495490144972 0.03220732730647113 1.9047792900754776e-06 5.7201553394925275 0.07068410805982905 FYDPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 FYDPSPPR 8 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4W8;A0A2R8YG73;A0A2R8Y802;A0A2R8Y4X4 Q3V6T2 CCDC88A Girdin 1 FYDPS(1)PPR 87.149 0.032876 17294000.0 8438.0 10420.0 10222.0 10482.0 10343.0 8564.2 9223.6 8489.7 5543.5 7308.2 True False 8634.588982510139 9200.021555873425 8833.908545426812 8651.515471509081 9407.477476204962 8478.051923671435 8527.856426037035 8264.525577567925 9406.914618779276 8246.27865789628 1.047089158725194 1.1156573695292096 1.0712600085334059 1.04914178024105 1.1408148895376908 1.0281064071917116 1.034146040877618 1.002212745946218 1.1407466336068597 1.0 13.009527498201004 FYDPS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 FYDPSPPR 8 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4W8;A0A2R8YG73;A0A2R8Y802;A0A2R8Y4X4 Q3V6T2 CCDC88A Girdin 1 FYDPS(1)PPR;FYDPS(1)PPR 92.051 0.026006 22667600.0 192723.0 197637.0 210966.0 235910.0 230360.0 164575.0 187117.0 179634.0 161659.0 218740.0 True False 182012.22719129553 212795.12239688376 197392.67724241325 203778.65103255058 201420.11735547095 187243.71238689573 195818.3112653013 180156.70519999063 193995.31712985827 212424.40784522638 0.8568329272402193 1.0017451598684812 0.9292372719533938 0.9592996073267854 0.9481966756956987 0.8814604417931228 0.9218258544374789 0.8480979517723491 0.9132440057039225 1.0 17.696590017670097 -6.744680591530889 24.861629563287433 0.9039880340545802 0.943123174258128 0.04744026190924722 0.049614648827842646 466.4915869016439 692037.6103130587 0.015357033689703889 0.015315283914474662 1.8001944086814265e-07 6.744680591530889 0.0391351402035478 FYDS(ph)NTVK ddPTM_A459_Selumetinib_30min_R1 1 FYDSNTVK 8 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 FYDS(0.993)NT(0.007)VK 138.76 0.0024474 9629000.0 2549.0 3260.1 3109.8 3675.1 2848.7 2738.4 3133.0 2250.5 2033.6 2542.9 True False 2608.386740509402 2878.405976420628 2687.5062409086563 3033.312775171055 2591.035587978835 2710.8541822682637 2896.6752876072287 2190.8094293457502 3450.870671732575 2869.305984943553 0.9090653817322714 1.0031714956595172 0.9366398198766963 1.0571590451099024 0.9030182216797653 0.9447769587814084 1.0095386489998954 0.7635328685200681 1.2026847920161652 1.0 11.486486111054447 -8.282450049273391 24.999883464278362 1.101342359400266 0.9478336996564564 0.3465175996890343 0.08773554230494517 1027.4332576050026 1222495.986033408 0.07816859487500348 0.020267073717232555 5.218551223710061e-09 8.282450049273391 -0.15350865974380967 FYDS(ph)NTVK ddPTM_A459_Selumetinib_30min_R2 4 FYDSNTVK 8 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 FYDS(0.8)NT(0.2)VK;FYDS(0.657)NT(0.342)VK;FYDS(0.977)NT(0.023)VK;FYDS(0.876)NT(0.124)VK 132.25 0.0033622 26069000.0 137601.0 115601.0 129221.0 135464.0 125522.0 119458.0 104856.0 92130.0 80193.0 128415.0 True False 129953.68728044647 124467.22498419923 120907.0615451867 117013.5695115657 109752.80417908236 135912.2551682444 109732.01176822218 92398.0830470574 96233.84077963284 124707.32528776047 1.0420693971310835 0.9980746896542989 0.9695265395693099 0.9383055024358711 0.8800830578783504 1.0898498131896317 0.8799163282110096 0.7409194514744829 0.7716775302298766 1.0 16.92818668576264 -7.514844781307897 23.883798382011577 0.8158626351260121 0.9795617998257943 0.39533079432992646 0.08341915532184345 191.6150040720359 569652.5678509751 0.03638936901609434 0.02227683694654256 3.056013150132069e-08 7.514844781307897 0.16369916469978218 FYEEVHDLER ddPTM_A459_Selumetinib_30min_R1 5 FYEEVHDLER 10 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7;E9PNW0;E9PJJ2;F8VVB5;P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2;F8W543;H0YH88 E9PNJ7;P55209 NAP1L4;NAP1L1 Nucleosome assembly protein 1-like 4;Nucleosome assembly protein 1-like 1 0 ;;;; 198.62 0.0001933 246338000.0 35073.3 37136.6 40616.1 43744.3 41550.5 35340.0 37886.6 35050.3 21752.800000000003 30460.600000000002 False True 35890.439649238295 32788.62960766306 35100.656708267445 36105.179187209964 37792.264611336606 34984.51168615268 35028.78325932334 34120.652184580045 36912.912838347904 34370.514721369895 1.0442217679947454 0.9539755186522332 1.0212432660033335 1.05046955158811 1.0995548049747197 1.017864060802122 1.0191521291807761 0.9927303231035264 1.073970324203416 1.0 15.0688838367414 -5.51459231265799 24.196865846650347 1.037009147541304 0.9962263279028474 0.1377742914789989 0.036828877554760456 426.324234803363 1244887.7344429218 0.009897630930471912 0.018287546636069008 3.0577902204191766e-06 5.51459231265799 -0.040782819638456536 FYEEVHDLER ddPTM_A459_Selumetinib_30min_R2 6 FYEEVHDLER 10 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7;E9PNW0;E9PJJ2;F8VVB5;P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2;F8W543;H0YH88 E9PNJ7;P55209 NAP1L4;NAP1L1 Nucleosome assembly protein 1-like 4;Nucleosome assembly protein 1-like 1 0 ;;;;; 192.12 1.2701e-12 143601600.0 435691.0 413860.0 477019.0 547351.0 535840.0 399764.0 400235.0 427709.0 385355.0 457652.0 False True 411477.0384292625 445601.73123035877 446328.1168790179 472800.8495668597 468522.98872962093 454827.86230372166 418846.72055060643 428953.5623789638 462436.7677183226 444438.3976373031 0.9258359327563329 1.0026175361967826 1.0042519261426575 1.0638163850835918 1.054191067244313 1.0233766135456577 0.942417943132849 0.9651586466411118 1.0404968836551958 1.0 18.761623939426315 -4.746911372273137 3.5712271726630376 1.0114581071300663 0.9121259779538238 0.341249937314956 0.03556532432146438 0.44143173889733783 8.908003955046226 0.010085479582051447 0.12423877839794598 1.7909713054218e-05 4.746911372273137 -0.09933212917624257 FYEQMNGPVAGASR ddPTM_A459_Selumetinib_30min_R1 1 FYEQMNGPVAGASR 14 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;P29692-3;E9PL71;E9PPR1;E9PMW7;P29692-4;E9PIZ1;E9PQZ1;H0YCK7;E9PK06;E9PN91;E9PK72;E9PKK3 P29692 EEF1D Elongation factor 1-delta 0 191.33 0.015668 12421000.0 1178.1 1513.8 1358.1 1340.6 1283.3 1324.8 1327.4 1240.4 747.7 967.51 False True 1205.5474378164495 1336.5635922534727 1173.6774795093077 1106.4893761786936 1167.2257415850174 1311.4737148221575 1227.273149304129 1207.5005626129612 1268.7922901526583 1091.6993328454657 1.104285219882148 1.2242964267183156 1.0750922384922317 1.0135477259060681 1.0691824263945418 1.2013140205956339 1.124186039488818 1.1060742882984682 1.162217702236391 1.0 10.09235986002223 -12.026679196585677 1.833178638329862 4.7098385999338153e-05 1.1192435959175167 0.266506015332014 0.05972198285181404 915519.3624384105 64020.08207365736 3794041.8611289794 0.016100436722173338 9.404177191508028e-13 12.026679196585677 1.1191964975315174 FYEQMNGPVAGASR ddPTM_A459_Selumetinib_30min_R2 1 FYEQMNGPVAGASR 14 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;P29692-3;E9PL71;E9PPR1;E9PMW7;P29692-4;E9PIZ1;E9PQZ1;H0YCK7;E9PK06;E9PN91;E9PK72;E9PKK3 P29692 EEF1D Elongation factor 1-delta 0 238.01 3.1456999999999995e-17 3483600.0 3079.1 2995.4 3577.6 4224.1 4594.5 2754.3 2895.3 3672.5 3058.3 3705.8 False True 2907.975948613908 3225.137548270947 3347.4211109963585 3648.770293021062 4017.297834648856 3133.679823953989 3029.937186928109 3683.186366984896 3670.0454560416965 3598.8039251752775 0.8080395623310532 0.896169287165004 0.930148232744668 1.013884159538742 1.116286943710943 0.870755920330215 0.84192894359493 1.0234473573898608 1.0197958911759688 1.0 11.813301786234772 -4.999396248937263 1.6905543915264527 0.9779609906166672 0.7905368666946948 0.3475942051991573 0.07484365334558435 0.802730699580526 3.128985760088003 0.023149405943432563 0.21483513722559303 1.0013911549564903e-05 4.999396248937263 -0.18742412392197239 FYHDWNDKEIEVLNK ddPTM_A459_Selumetinib_30min_R1 1 FYHDWNDKEIEVLNK 15 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 108.32 0.0032024 9106200.0 3579.3 3762.9 4581.9 4860.1 3902.8 3700.8 3831.8 3399.2 2483.5 3015.4 False True 3662.6907258945885 3322.3379186752495 3959.7031465751397 4011.374770376003 3549.7924290953033 3663.573312057548 3542.764241000123 3309.0421738422906 4214.318112336665 3402.455962483298 1.0764843884184636 0.9764528785408366 1.1637779269551904 1.1789644934737915 1.0433029753321101 1.0767437852108663 1.0412373532718466 0.9725451880432777 1.2386106267958352 1.0 11.732360773909916 FYQGLPWGVSS(ph)LPR ddPTM_A459_Selumetinib_30min_R1 2 FYQGLPWGVSSLPR 14 0 Q5JTC6 Q5JTC6 AMER1 APC membrane recruitment protein 1 1 FYQGLPWGVS(0.403)S(0.597)LPR;FYQGLPWGVS(0.221)S(0.779)LPR 105.58 0.0057951 17390700.0 5522.6 5643.5 6823.200000000001 7631.400000000001 6824.9 5982.4 5785.0 5816.9 3816.0 5300.6 True False 5651.265834891026 4982.756396408026 5896.646917154783 6298.719249119863 6207.589000033958 5922.222487584598 5348.6327924697825 5662.616916045903 6475.473290387242 5980.983642216287 0.944872310802194 0.8330998201094625 0.985899188142529 1.0531243062864886 1.0378876404573647 0.9901753360071196 0.8942731016210933 0.9467701727315858 1.0826769771916178 1.0 12.546167056551631 -5.362498486167858 7.06508212434528 0.9968077198781139 0.8895826010656179 0.3798153787252546 0.05621163598115308 0.26111517619194596 15.671522000565112 0.015585449337113923 0.032728086925217836 4.340117764888148e-06 5.362498486167858 -0.10722511881249597 FYS(ph)PLPNDQLLK ddPTM_A459_Selumetinib_30min_R2 1 FYSPLPNDQLLK 12 0 Q9UIF8-4;Q9UIF8-2;Q9UIF8-5;Q9UIF8-3;Q9UIF8 Q9UIF8-4 BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 1 FYS(1)PLPNDQLLK 92.039 0.022215 1713100.0 10968.0 11601.0 10630.0 11643.0 12659.0 8273.4 8657.4 9305.7 7506.8 12994.0 True False 10358.442468382764 12490.759396905683 9946.077373068905 10057.203314704726 11068.663247104116 9412.985751552449 9059.986254312653 9332.778046358433 9008.369757516853 12618.829457533477 0.8208718964974001 0.9898508763385073 0.7881933428564619 0.79699970179885 0.8771545161422316 0.7459476160788329 0.7179735873919602 0.7395914238928666 0.7138831527783928 1.0 13.623290469415547 -5.6628026155246225 1.0812892694359715 0.7745989196458958 0.904377505026517 0.10264232343696089 0.09457147747161955 1.0568829701369555 2.271897650508709 0.03363591577931146 0.11220531937153003 2.1736888841459365e-06 5.6628026155246225 0.12977858538062126 FYSLPQS(ph)PQQFK ddPTM_A459_Selumetinib_30min_R1 1 FYSLPQSPQQFK 12 0 A0A3B3ITS3;A0A3B3IS54;A0A3B3IS01;A0A3B3IT01;A0A3B3ISK7;Q6PI48 A0A3B3ITS3 DARS2 Aspartate--tRNA ligase, mitochondrial 1 FYS(0.009)LPQS(0.991)PQQFK 93.766 0.019849 8248000.0 795.24 1264.6 1358.5 1061.3 1101.9 893.34 1046.9 939.42 591.39 708.76 True False 813.7675447323254 1116.5400441034099 1174.0231617063503 875.9638780683639 1002.2333395562462 884.3538106878223 967.931490135975 914.503529933786 1003.5456365833628 799.7362499070323 1.01754490286882 1.3961353436626205 1.4680129378189724 1.0953159596932025 1.2532048405618148 1.1058068341789267 1.2103133880057269 1.1435064123204308 1.254845752834166 1.0 9.643380472662447 -5.79041741711339 24.999996942529346 1.1625754621652309 1.3041218573598539 0.19435013240720733 0.13076718458157482 322.01694229163814 277809.8342158639 0.03592980341050362 0.05330235630262729 1.6202520622234468e-06 5.79041741711339 0.14154639519462298 GAAAADLLSS(ph)SPESQHGGTQSPGGGQPLLQPTK ddPTM_A459_Selumetinib_30min_R1 1 GAAAADLLSSSPESQHGGTQSPGGGQPLLQPTK 33 0 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 GAAAADLLS(0.068)S(0.33)S(0.33)PES(0.263)QHGGT(0.007)QS(0.001)PGGGQPLLQPTK 89.381 1.0874e-08 16556000.0 2411.3 2679.6 2001.7 2079.4 3064.9 2141.5 3268.3 2242.4 433.97 1427.7 True False 2467.478598426963 2365.8711862877562 1729.8801345510512 1716.2718251722938 2787.6803361520456 2119.958454326427 3021.7694996765736 2182.9242676582585 736.4153940852601 1610.959201975661 1.5316828603734203 1.468610243751847 1.0738199530003907 1.0653726196588211 1.7304475077539319 1.315960361830725 1.8757579310330836 1.355046276144763 0.45712851894829437 1.0 10.653704242485155 -8.182412559010169 6.813302111925126 0.7332125591707757 1.4288482828784341 0.5194343694181769 0.2691316987918798 0.18400527380191867 13.225837571078248 0.1892896847410254 0.07009662024560591 6.570333904726674e-09 8.182412559010169 0.6956357237076585 GAAAADLLSS(ph)SPESQHGGTQSPGGGQPLLQPTK ddPTM_A459_Selumetinib_30min_R2 3 GAAAADLLSSSPESQHGGTQSPGGGQPLLQPTK 33 0 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 GAAAADLLS(0.035)S(0.407)S(0.407)PES(0.151)QHGGTQSPGGGQPLLQPTK;GAAAADLLS(0.109)S(0.358)S(0.358)PES(0.109)QHGGT(0.058)QS(0.008)PGGGQPLLQPTK;GAAAADLLS(0.145)S(0.404)S(0.404)PES(0.046)QHGGTQS(0.001)PGGGQPLLQPTK 93.679 1.5812e-09 28292300.0 85663.8 57725.6 117454.0 173864.0 189652.0 135783.0 103398.0 123754.0 136797.0 148249.0 True False 80902.94893536167 62152.96790294101 109897.13751424589 150183.42326787103 165826.22024960816 154485.87573464913 108206.2118792502 124114.10365142244 164160.22242753676 143968.66617283958 0.561948311990574 0.43171177142340217 0.7633406659634563 1.0431674284428696 1.1518216057550175 1.073052073353123 0.751595571145632 0.8620910851700118 1.140249658425372 1.0 17.13539532724328 -5.505574968902929 3.3359441939310828 0.9948203129696551 0.5013692288417594 0.7424655716816811 0.11927390491458928 0.12801090083117225 2.938276019705184 0.03615057812899837 0.07684126842247103 3.1219434427161816e-06 5.505574968902929 -0.49345108412789573 GAAAADLLSSSPES(ph)QHGGTQSPGGGQPLLQPTK ddPTM_A459_Selumetinib_30min_R1 1 GAAAADLLSSSPESQHGGTQSPGGGQPLLQPTK 33 0 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 GAAAADLLS(0.068)S(0.296)S(0.296)PES(0.336)QHGGT(0.003)QSPGGGQPLLQPTK 91.819 5.603100000000001e-09 21248000.0 2683.8 3407.8 2324.8 2432.2 3180.7 3004.7 3357.2 2554.2 776.99 2373.1 True False 2746.327318234265 3008.813191756761 2009.1049292123118 2007.4619280485003 2893.006246598195 2974.4754460493173 3103.9637011027735 2486.4543187891204 1318.4952808956987 2677.7105009514894 1.0256251813847663 1.1236514144033192 0.7503069986461952 0.7496934143310768 1.080402920917031 1.110827867684866 1.1591856924039476 0.928574734985575 0.4923965008268028 1.0 11.38678427765505 -8.01864863654506 24.476418066027293 0.7342939599518873 0.9964901319836894 0.24141387481990506 0.17726590129438421 813.3828050174476 1067561.061685382 0.11905841603900072 0.046792104212443224 9.57968797009208e-09 8.01864863654506 0.2621961720318021 GAAAADLLSSSPESQHGGT(ph)QSPGGGQPLLQPTK ddPTM_A459_Selumetinib_30min_R2 1 GAAAADLLSSSPESQHGGTQSPGGGQPLLQPTK 33 0 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 GAAAADLLS(0.043)S(0.215)S(0.215)PES(0.215)QHGGT(0.255)QS(0.055)PGGGQPLLQPTK 59.598 0.00098672 11293000.0 3650.3 4344.7 5905.5 8339.8 6930.6 6043.7 5383.0 6453.1 4977.9 6752.1 True False 3447.4309393086796 4677.924519587628 5525.546559422237 7203.904853042553 6059.9160676498805 6876.164815753811 5633.320166212143 6471.877452631787 5973.619094147058 6557.149328937343 0.5257514761932947 0.7134082640063555 0.842675114174609 1.0986336427098 0.9241692942551845 1.048651551278331 0.8591111599901726 0.9869955872547781 0.9110085487583592 1.0 12.678853035047016 -5.119857195777263 1.780725588772102 0.9703978024606197 0.5126210449584772 0.8102861223269857 0.07007804201987598 0.19300860507788029 0.9655998888708728 0.019182910183149268 0.11895877672250292 7.5882705066751964e-06 5.119857195777263 -0.45777675750214253 GAAAHPDSEEQQQR ddPTM_A459_Selumetinib_30min_R1 1 GAAAHPDSEEQQQR 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 113.95 0.0044026 1167100.0 465.56 373.05 696.03 533.04 528.91 490.47 394.01 552.08 186.31 332.05 False True 476.4066421779355 329.3731325737602 601.512949019118 439.954570400038 481.0701838866448 485.53631711112894 364.2895084807293 537.4370449914255 316.1544624559873 374.6718519408965 1.2715303797443727 0.8790976180023204 1.6054393889029195 1.1742397196932737 1.2839773828607024 1.2958975022968127 0.9722895023835284 1.4344206595914892 0.8438169582748902 1.0 8.549483785828022 -8.276252065688784 24.890785885381927 0.9219084304438697 1.2320539229916494 0.28894608056487003 0.1990714077602077 1089.2055832003864 1830248.5405716621 0.17849266093947408 0.04688309623442513 5.293561149959706e-09 8.276252065688784 0.3101454925477797 GAAAHPDSEEQQQR ddPTM_A459_Selumetinib_30min_R2 3 GAAAHPDSEEQQQR 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 ;; 161.25 0.0003998 8584410.0 58400.7 51386.5 60832.9 67666.3 73943.6 50110.1 57007.6 47171.4 49535.3 60984.6 False True 55155.02289052527 55327.67931636012 56918.97744385357 58450.03320912173 64654.143903828684 57012.311420802645 59658.5663584164 47308.66096435433 59443.744131923704 59223.816140980205 0.9312980230661038 0.9342133439131063 0.9610825703693249 0.9869345985740514 1.0916916219975048 0.9626585238122253 1.0073408004712376 0.7988114249804121 1.0037135059047861 1.0 15.853889834439904 -10.373028776012328 11.537854642561316 0.9999879362568229 0.9639990104342614 0.022754580679974157 0.07038535197812955 0.0 0.0 0.07001867156397902 0.01698202227198337 4.236148967282497e-11 10.373028776012328 -0.035988925822561524 GAADEVEVEPPEPPGPVAS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 GAADEVEVEPPEPPGPVASR 20 0 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 GAADEVEVEPPEPPGPVAS(1)R;GAADEVEVEPPEPPGPVAS(1)R 233.59 2.6289e-24 5813600.0 1048.4 1518.65 1065.6 644.2 1415.08 759.35 1653.75 1629.92 447.08 1664.28 True False 1072.8256801687166 1340.8457519987692 920.8973729218161 531.7025631316684 1287.086263852665 751.711628434636 1529.0063060582365 1586.6892268736838 758.6621065687444 1877.9065494600075 0.5712881082805787 0.7140109034628639 0.4903850903478772 0.28313579463502037 0.685383553416312 0.40029235142227443 0.814207877648599 0.8449244864340756 0.40399353566709584 1.0 10.874909556394398 -7.271947913370019 24.912798274308486 0.752858523006533 0.5275637595987183 0.29460191687633375 0.1827381562203292 973.5853013250278 2308089.116068963 0.07475898970118222 0.050999689641361874 5.346284756289646e-08 7.271947913370019 -0.22529476340781474 GAADEVEVEPPEPPGPVAS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 GAADEVEVEPPEPPGPVASR 20 0 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 GAADEVEVEPPEPPGPVAS(1)R;GAADEVEVEPPEPPGPVAS(1)R 204.78 3.0201999999999998e-16 6037800.0 17476.2 11530.3 15381.5 19848.2 22762.0 22389.9 26224.3 28128.9 29275.9 17333.1 True False 16504.942766771594 12414.636934242011 14391.871036110948 17144.84091994522 19902.434065138154 25473.905489724195 27443.781912464616 28210.750442009907 35131.8980369915 16832.64836619775 0.9805315484351093 0.7375331952619109 0.8549974266088624 1.0185468469937502 1.1823709277444987 1.5133628966478778 1.6303900203592125 1.6759543613268209 2.087128375326911 1.0 14.038974560625656 -6.5731046669004245 1.3758312682839995 1.663478606949958 0.8498944342540615 0.6141571487298669 0.2564818209502094 0.2503231629248457 0.9826381125280149 0.10563225843763233 0.11261702671961023 2.6723622798603225e-07 6.5731046669004245 -0.8135841726958966 GAAEEAELEDS(ph)DDEEKPVK ddPTM_A459_Selumetinib_30min_R2 2 GAAEEAELEDSDDEEKPVK 19 1 Q9UBB9;F6XM96 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 GAAEEAELEDS(1)DDEEKPVK;GAAEEAELEDS(1)DDEEKPVK 97.256 0.00085851 15835700.0 55195.0 44992.0 43332.0 50839.0 42637.0 40382.0 50698.0 50280.0 36239.0 43294.0 True False 52127.482863091376 48442.741727918285 40544.06629631437 43914.64049783329 37280.55888038378 45944.253948702004 53055.557456181195 50426.30647569789 43487.812602261074 42043.98972867899 1.239831975972876 1.1521918362299137 0.9643249025117734 1.0444927035047362 0.8867036435163529 1.0927662727822085 1.2619058704600292 1.1993701549522824 1.0343407674414216 1.0 15.359611958665608 -7.003795231589727 24.993641454674286 1.1457780549428966 1.050155735654144 0.0553059181661284 0.1142503056040868 356.80771262970046 2349783.0454722974 0.04267495145684664 0.03683869566191315 9.912992290269544e-08 7.003795231589727 -0.09562231928875264 GAAEEAELEDS(ph)DDEEKPVKQDDFPK ddPTM_A459_Selumetinib_30min_R2 3 GAAEEAELEDSDDEEKPVKQDDFPK 25 2 Q9UBB9;F6XM96 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 GAAEEAELEDS(1)DDEEKPVKQDDFPK;GAAEEAELEDS(1)DDEEKPVKQDDFPK;GAAEEAELEDS(1)DDEEKPVKQDDFPK 69.47 0.00052679 43426000.0 202412.0 174887.0 183692.0 155150.0 134324.0 120199.0 152211.0 146657.0 98223.0 146508.0 True False 191162.7513594357 188300.27054966294 171873.45670872714 134018.30235132133 117449.01824820384 136755.32119211604 159289.11310037455 147083.7475896266 117870.34457992451 142277.93336650092 1.3435867870459568 1.3234678498218748 1.2080120412347404 0.9419472098044663 0.8254900494348689 0.9611843379805152 1.1195630223982358 1.0337776499096747 0.8284513402109681 1.0 17.118352398484255 -5.616958963117574 3.26514544907816 0.960917835527886 1.325279033372355 0.7761181235502429 0.08355949236371435 0.1196392959226368 2.5195709781189364 0.02582435689191424 0.049461563655026096 2.4156890843298857e-06 5.616958963117574 0.36436119784446896 GAAEEEQQDS(ph)GSEPR ddPTM_A459_Selumetinib_30min_R1 2 GAAEEEQQDSGSEPR 15 0 D6RGI7;A0A499FJW5;Q9UJV9 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 GAAEEEQQDS(0.962)GS(0.038)EPR;GAAEEEQQDS(0.759)GS(0.241)EPR 120.32 0.0018057 1913870.0 610.5999999999999 711.4200000000001 770.94 747.17 522.7 605.14 671.54 621.58 393.76 821.5799999999999 True False 624.8257919792238 628.1266156698149 666.2505824702941 616.6907856179585 475.4218772901802 599.0528410231587 620.885197140044 605.0936792236089 668.1819609074638 927.0377958668932 0.6740024999681222 0.6775631138991911 0.7186876149394413 0.6652272306128333 0.5128397994232833 0.6462010974029073 0.6697517619111104 0.6527173777826099 0.7207710018798449 1.0 9.85648434933551 -8.895422590075258 1.5785316467282373 1.0000043777094714 0.6501248186290343 0.809184326603477 0.05053884145481348 0.7203275190601778 2.5013325246027502 0.05286101807919677 0.015159054762700441 1.2722645020403478e-09 8.895422590075258 -0.3498795590804371 GAAEEEQQDS(ph)GSEPR ddPTM_A459_Selumetinib_30min_R2 2 GAAEEEQQDSGSEPR 15 0 D6RGI7;A0A499FJW5;Q9UJV9 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 GAAEEEQQDS(0.918)GS(0.082)EPR;GAAEEEQQDS(0.956)GS(0.044)EPR 183.31 2.0855e-05 5016000.0 8916.7 4701.9 7715.0 8267.8 7593.3 8927.4 10578.3 10593.0 10617.0 6062.0 True False 8421.145510378245 5062.5206110086065 7218.625299456879 7141.7113772494795 6639.361769036706 10157.068315131544 11070.211910503787 10623.823876234448 12740.696663765717 5886.974309032471 1.4304709122745036 0.8599528968966463 1.2262029559703083 1.2131378535645803 1.1278054600730696 1.7253461255211198 1.8804586752686518 1.8046322811251545 2.1642181526454904 1.0 12.523310616353461 -6.7851444814661175 6.12060822374302 1.7797215321259652 1.1584113912901666 0.43289870657753016 0.30659468647680205 0.139560348326331 16.78365790435092 0.10083488614302004 0.0916076522478791 1.640044071143671e-07 6.7851444814661175 -0.6213101408357986 GAAGGAS(ph)TPTPQHGEEK ddPTM_A459_Selumetinib_30min_R2 2 GAAGGASTPTPQHGEEK 17 0 O60299-2;O60299 O60299-2 LZTS3 Leucine zipper putative tumor suppressor 3 1 GAAGGAS(0.494)T(0.494)PT(0.013)PQHGEEK;GAAGGAS(0.498)T(0.498)PT(0.004)PQHGEEK 70.986 0.02033 7603000.0 45995.0 42801.0 49880.0 52225.0 47126.0 39011.0 43041.0 44545.0 39279.0 49725.0 True False 43438.782032573414 46083.699073093725 46670.77510523771 45111.86490684996 41205.61056821461 44384.41114340086 45042.49178412353 44674.618575178276 47135.897546958025 48289.31004893433 0.8995527579200118 0.9543250675231116 0.966482541538563 0.9341998231313622 0.8533070885970124 0.9191353344751373 0.9327632086372614 0.9251451000212454 0.9761145375486318 1.0 15.559416230177602 -8.380832033003475 2.577960553219718 0.9998422885353708 0.9232873375072942 0.45109165906128323 0.029218012536231196 0.270235220845599 3.4779337064457434 0.030231578237721272 0.008319759927538075 4.160714984860284e-09 8.380832033003475 -0.07655495102807663 GAAGGAST(ph)PTPQHGEEK ddPTM_A459_Selumetinib_30min_R1 1 GAAGGASTPTPQHGEEK 17 0 O60299-2;O60299 O60299-2 LZTS3 Leucine zipper putative tumor suppressor 3 1 GAAGGAS(0.216)T(0.782)PT(0.001)PQHGEEK 109.28 0.0030533 4698500.0 2798.0 2654.9 3148.4 2977.0 3428.6 2516.2 2911.3 2769.1 1451.7 2671.0 True False 2863.1879560397465 2344.0630737704764 2720.8645729232785 2457.122835211079 3118.483735368493 2490.8893125268078 2691.6982970989225 2695.654472695543 2463.428872027035 3013.8488677432183 0.9500104622643911 0.7777639744509551 0.902787330195715 0.8152773888263952 1.0347180207823843 0.8264811614100595 0.893109912015753 0.8944225775707392 0.8173697421900455 1.0 11.55739135812598 -11.907629250075441 2.3330518586716336 1.957319114758287 0.8788347671563963 0.20452229122532029 0.07152604402980825 10775475.786051236 1679645.482777444 54111823.040516496 0.016670789866011983 1.2370029915577611e-12 11.907629250075441 -1.0784843476018906 GAAGGAST(ph)PTPQHGEEK ddPTM_A459_Selumetinib_30min_R2 1 GAAGGASTPTPQHGEEK 17 0 O60299-2;O60299 O60299-2 LZTS3 Leucine zipper putative tumor suppressor 3 1 GAAGGAS(0.023)T(0.912)PT(0.065)PQHGEEK 93.115 0.010186 2301400.0 22307.0 21371.0 21289.0 22633.0 21431.0 16354.0 18869.0 19929.0 15454.0 19111.0 True False 21067.2662419962 23010.086981404307 19919.28891771061 19550.346355897273 18738.646184429137 18606.61505316904 19746.445888214188 19986.990090576448 18545.23182083784 18559.215773658798 1.1351377395965778 1.239820004359379 1.07328289948448 1.0534036887294125 1.0096679952945538 1.0025539484043025 1.063969842747366 1.0769307461225865 0.9992465224289915 1.0 14.179848129704757 -5.432540684359212 4.167231490402797 1.033591587020261 1.186448797290457 0.7510488777009231 0.03574929716657669 0.10443228725218487 3.2041060690464667 0.009478019606539592 0.02061946665429264 3.6936804063528644e-06 5.432540684359212 0.15285721027019594 GAANAS(ph)GSSPDAPAK ddPTM_A459_Selumetinib_30min_R1 2 GAANASGSSPDAPAK 15 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 GAANAS(0.726)GS(0.233)S(0.04)PDAPAK;GAANAS(0.626)GS(0.319)S(0.055)PDAPAK 98.676 0.0087274 11746800.0 7954.8 10580.7 9062.1 10339.0 9173.900000000001 9254.8 9315.0 8796.599999999999 5086.3 8070.5 True False 8140.1313626536685 9341.906725166014 7831.516594552169 8533.487737066624 8344.122364783596 9161.705114686067 8612.362050450476 8563.285592616236 8631.079611346078 9106.427288327079 0.8938885805510093 1.0258585973821788 0.8599988059632199 0.9370840470010815 0.916289352628925 1.0060701990592782 0.9457454364666249 0.940356225497231 0.9478008595544032 1.0 13.152669439196877 -6.710391221817276 24.999891752736076 0.9628768502339314 0.9290166269695721 0.17167855101222462 0.04458097591055307 229.4668308610696 112376.20084561252 0.014289976818406451 0.014289961539369959 1.9480889286650056e-07 6.710391221817276 -0.033860223264359335 GAANASGS(ph)SPDAPAK ddPTM_A459_Selumetinib_30min_R1 1 GAANASGSSPDAPAK 15 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 GAANAS(0.114)GS(0.443)S(0.443)PDAPAK 101.75 0.0067393 25809000.0 4179.5 6124.5 4574.6 5757.2 4514.9 4691.3 5030.0 4147.9 2073.0 3370.9 True False 4276.874218108691 5407.440692797192 3953.3944464791116 4751.81309602863 4106.528092170337 4644.1097813595925 4650.583050323769 4037.8842177219476 3517.7295940704294 3803.5878503465406 1.1244315594601106 1.4216684103417059 1.0393856017073255 1.249297579808942 1.0796459168929662 1.220981337643213 1.22268322260522 1.0615987789933814 0.9248451021710812 1.0 11.893145211597894 -7.95211540671601 3.641951593024323 0.9667884670361568 1.1952277917202498 0.46599624988454846 0.10083806894292659 0.193284902402701 5.236413144197144 0.06278360037666209 0.025820514838709355 1.1165664989134569e-08 7.95211540671601 0.228439324684093 GAANASGS(ph)SPDAPAKDAR ddPTM_A459_Selumetinib_30min_R1 1 GAANASGSSPDAPAKDAR 18 1 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 GAANAS(0.102)GS(0.723)S(0.175)PDAPAKDAR 81.37899999999998 0.0057627 2502200.0 922.69 796.12 1059.7 1280.9 1335.1 732.58 1091.3 997.94 366.67 587.38 True False 944.1868817577954 702.9099002938532 915.798560515436 1057.2148604709007 1214.340440731049 725.2109103294201 1008.98236238933 971.4713894340365 622.2122094827808 662.77594456571 1.4245943738596043 1.0605543337189784 1.381761918223392 1.5951316114281282 1.83220355338448 1.09420222063826 1.522358152347359 1.4657613895003416 0.9387972128205273 1.0 9.372377430708333 -8.26256690454942 24.989928488300965 0.9693985442851841 1.4205304879623915 0.4204804349342164 0.21256537113369856 102.24852431761609 2266033.9241958424 0.17846003764848706 0.05608030101633669 5.463023836494293e-09 8.26256690454942 0.4511319436772073 GAANASGSS(ph)PDAPAK ddPTM_A459_Selumetinib_30min_R1 1 GAANASGSSPDAPAK 15 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 GAANASGS(0.095)S(0.905)PDAPAK 238.83 5.2088000000000005e-20 8684100.0 5244.5 5910.4 4361.7 3774.4 4825.3 4535.3 5050.8 4831.5 2615.3 4913.8 True False 5366.686645979427 5218.407620329584 3769.4050971031197 3115.2718942629153 4388.852466975908 4489.678999722927 4669.814089577591 4703.352925076201 4437.973086045534 5544.534094465228 0.9679238245349894 0.9411805449151811 0.6798416301318966 0.5618636013750375 0.791563798184059 0.8097486503337947 0.8422374197751229 0.8482864105338036 0.800423085228332 1.0 12.436850520911213 -9.39997367501255 0.6265942488553233 1.0087355722997868 0.7899793472477239 0.21612118867338292 0.1111662330257479 6.14037551990524 3.038172348665076 0.2671100386738218 0.049850791945826534 3.9813130275950513e-10 9.39997367501255 -0.21875622505206294 GAANASGSS(ph)PDAPAK ddPTM_A459_Selumetinib_30min_R2 2 GAANASGSSPDAPAK 15 0 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 GAANAS(0.001)GS(0.231)S(0.768)PDAPAK;GAANASGS(0.31)S(0.69)PDAPAK 176.44 1.9284e-05 19771200.0 92563.0 78310.0 93626.0 96256.0 107062.0 91562.0 94830.0 93881.0 84764.0 96228.0 True False 87418.71901904752 84316.12519366275 87602.2050922814 83145.76674913814 93611.91441357619 104173.83438291945 99239.7829020802 94154.17816716377 101719.16850404434 93449.64760962989 0.9354633351237925 0.9022626339467765 0.9374268104062287 0.889738686832352 1.0017364089442493 1.11475898569557 1.0619599478495374 1.0075391462199723 1.088491729032077 1.0 16.511901603254522 -6.4604569466760005 4.49191591540413 1.0560728310047875 0.9178873069228896 0.7803658932203313 0.03454133177343952 0.0969515975808505 3.903066389167867 0.010837979349086193 0.012060140836453856 3.4637222014994093e-07 6.4604569466760005 -0.138185524081898 GAANASGSS(ph)PDAPAKDAR ddPTM_A459_Selumetinib_30min_R1 3 GAANASGSSPDAPAKDAR 18 1 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 GAANAS(0.136)GS(0.235)S(0.628)PDAPAKDAR;GAANAS(0.13)GS(0.083)S(0.787)PDAPAKDAR;GAANAS(0.001)GS(0.059)S(0.94)PDAPAKDAR 166.47 9.0652e-06 7142500.0 2572.5 2081.41 3554.78 3099.98 3631.82 2135.75 2717.8900000000003 2460.72 1201.1000000000001 1598.5500000000002 True False 2632.4342447863633 1837.7175495787424 3072.0604010088327 2558.6266868315874 3303.3225222498995 2114.2662941058443 2512.8773691142087 2395.453712054956 2038.1789751268666 1803.7394636955905 1.4594315297581293 1.018837579687665 1.7031619382073304 1.418512339686435 1.8313745353677018 1.1721572525635333 1.3931487444232669 1.3280486235783922 1.1299741543332122 1.0 10.816775252091787 -8.265064063744376 1.0438437033975014 0.9968874561943966 1.4431894038142106 0.3168401997331204 0.2167129438456055 0.6178988293388178 1.3812535043130725 0.2042870402910347 0.06950487185167711 5.431702013387312e-09 8.265064063744376 0.446301947619814 GAAPPDS(ph)PVVYSDR ddPTM_A459_Selumetinib_30min_R1 2 GAAPPDSPVVYSDR 14 0 B4DEY6;Q9NZU5-2;Q9NZU5 B4DEY6 LMCD1 LIM and cysteine-rich domains protein 1 1 GAAPPDS(0.999)PVVYS(0.001)DR;GAAPPDS(0.999)PVVYS(0.001)DR 144.4 0.00053007 17000200.0 5216.7 6171.9 6424.2 7003.0 6491.6 5455.700000000001 6328.9 6024.9 3399.6 5122.7 True False 5338.238960068812 5449.291078761533 5551.828925604663 5780.057512590928 5904.435926185064 5400.82061137926 5851.505977573377 5865.100080366679 5768.872903039957 5780.248444323543 0.9235310577889082 0.9427434013001597 0.9604827507123508 0.999966968248086 1.0214848000146912 0.9343578677285235 1.0123277630600485 1.0146795828692217 0.9980319978642516 1.0 12.496915788061132 -5.473092473254163 2.0711588393769613 0.9970015321912016 0.9298928503820558 0.5628492776318965 0.02302529044015831 0.2582414979799787 2.1402888833139215 0.006852045271281233 0.018668818040282135 3.364399244238696e-06 5.473092473254163 -0.06710868180914575 GAAPT(ph)PPGK ddPTM_A459_Selumetinib_30min_R1 2 GAAPTPPGK 9 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;H0YAB7;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 GAAPT(1)PPGK;GAAPT(1)PPGK 101.97 0.038693 23336000.0 14390.8 16056.8 14868.0 15684.2 14068.3 12501.5 14384.599999999999 12655.3 7341.4 12458.4 True False 14726.07764037768 14176.862391396204 12849.007264078049 12945.24889889741 12795.824748960105 12375.746260453807 13299.55804089209 12319.640333792166 12457.819605358725 14057.556995092502 1.0475559619298402 1.0084869224677766 0.9140284665794804 0.9208747226432445 0.9102452690340955 0.8803625170983965 0.9460788987400137 0.8763713594113797 0.8862008960524047 1.0 13.77905827571649 -5.154521680453437 2.6679203160422693 0.9110588306473824 1.0454196089431227 0.6254773269779331 0.034786954259306634 0.16965845504137872 2.2345489504604594 0.008766356286345157 0.034040061316625174 7.0061320661822576e-06 5.154521680453437 0.13436077829574034 GAAPT(ph)PPGK ddPTM_A459_Selumetinib_30min_R2 2 GAAPTPPGK 9 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;H0YAB7;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 GAAPT(1)PPGK;GAAPT(1)PPGK 105.4 0.032204 13002600.0 145901.0 146105.0 170294.0 185351.0 190856.0 149516.0 149843.0 161520.0 144812.0 165171.0 True False 137792.40650797894 157310.78369837956 159337.469442088 160105.8740516905 166878.96300571162 170110.47182888724 156810.9964082716 161989.99645892443 173778.44638534842 160402.0840642038 0.8590437419305915 0.980727804231104 0.9933628379685536 0.9981533281550461 1.0403790198817824 1.060525321858022 0.9776119638539434 1.0098995745846109 1.0833926965424618 1.0 17.291333360927645 -3.749951474197973 0.9379761008393549 1.0253967318729054 3.8290256729528655e-18 0.728316110757234 0.030003260265704285 6.300175919595346 1.0111597772231031 0.00996353957072571 10.342612082000443 0.00017784781168134938 3.749951474197973 -1.0253967318729054 GAAQENGAPECS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 GAAQENGAPECSPR 14 0 Q6IE81-2;Q6IE81;Q6IE81-3 Q6IE81-2 JADE1 Protein Jade-1 1 GAAQENGAPECS(1)PR;GAAQENGAPECS(1)PR 172.09 0.00012899 7544100.0 2656.67 3049.57 2744.8 2780.67 3119.47 3153.56 3190.25 2964.54 1719.4099999999999 2437.29 True False 2718.565242020052 2692.52492669337 2372.0712361071696 2295.0781841405405 2837.3144892871596 3121.838049603385 2949.6068740149885 2885.9107690169517 2917.7131892622456 2750.1399127150366 0.9885188856941417 0.9790501618643879 0.8625274754713755 0.8345314263937783 1.0316982333040872 1.1351560824850524 1.0725297503511488 1.0493687087243053 1.0609326368351109 1.0 11.425289301934106 -6.443308450819947 6.543281980164037 1.0690062057552943 0.9176022752834258 0.6338462379528143 0.05327388310883212 0.16413479252458738 11.201206384756729 0.017820872653327432 0.02013158390235714 3.6032263863827223e-07 6.443308450819947 -0.1514039304718685 GAAQENGAPECS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 GAAQENGAPECSPR 14 0 Q6IE81-2;Q6IE81;Q6IE81-3 Q6IE81-2 JADE1 Protein Jade-1 1 GAAQENGAPECS(1)PR;GAAQENGAPECS(1)PR 176.43 6.9275e-05 16072600.0 16751.9 18760.7 20860.2 21321.3 25314.0 16819.4 19737.1 19895.2 15050.099999999999 18960.3 True False 15820.89646116896 20199.58536484168 19518.07744286848 18417.302158705992 22133.82900996869 19136.11967868849 20654.914258321693 19953.09173817234 18060.540534928918 18412.866874224408 0.8592304810130429 1.0970364095293843 1.0600238179200232 1.0002408796257465 1.2020848877668875 1.0392797498295359 1.1217652524950288 1.0836493781478453 0.9808652100891089 1.0 14.168426650627337 -4.7570863574091105 24.997977336772937 1.0706837791220167 0.859230168001613 0.48680179276424984 0.06313776008795437 107.28848867906494 616043.7787749788 0.015055054971704663 0.11580638693923838 1.74949877445654e-05 4.7570863574091105 -0.21145361112040373 GAAS(ph)PGPSR ddPTM_A459_Selumetinib_30min_R2 1 GAASPGPSR 9 0 M0QZR4;Q92888-2;Q92888;Q92888-3;Q92888-4 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 1 GAAS(1)PGPSR 82.029 0.042377 418510.0 2867.2 630.43 2753.5 3995.9 4097.8 2988.9 8263.1 21357.0 6515.6 6199.0 True False 2707.852502311001 678.7819538480516 2576.342807784124 3451.651526688016 3582.9977292031936 3400.593844467223 8647.350523022022 21419.14533415831 7818.902061074871 6020.018763063727 0.4498079838098232 0.11275412595269116 0.42796258769016915 0.5733622539294861 0.5951804919923078 0.5648809378023569 1.4364324869016163 3.557986474324145 1.2988168922409886 1.0 12.55555226821464 -7.390038626615993 3.686663695924796 2.1314967091399772 0.44756954447863695 0.5135595785204748 0.6533536236851636 0.16671305365261932 4.05058029221939 0.2800870530388321 0.17957119788424405 4.0734404657748085e-08 7.390038626615993 -1.6839271646613403 GAAS(ph)PVLQEDHCDSLPSVLQVEEK ddPTM_A459_Selumetinib_30min_R1 2 GAASPVLQEDHCDSLPSVLQVEEK 24 0 Q8N9B5-2;Q8N9B5 Q8N9B5-2 JMY Junction-mediating and -regulatory protein 1 GAAS(0.994)PVLQEDHCDS(0.005)LPS(0.001)VLQVEEK;GAAS(1)PVLQEDHCDSLPSVLQVEEK 147.69 1.0933e-09 54484000.0 3928.5 5335.6 3329.3999999999996 3651.7000000000003 3891.8 3859.8 5144.1 3928.7999999999997 1930.26 3847.5 True False 4020.0264064696726 4710.905471546856 2877.2857670851117 3013.9991458986556 3539.7873771530985 3820.9739164180005 4756.07639546133 3824.5954614590473 3275.510239387548 4341.3641028236725 0.9259823205925073 1.0851210264724926 0.6627607588162653 0.6942516394647287 0.8153629350854908 0.8801321027031103 1.0955258031382173 0.8809662978904458 0.7544887187087392 1.0 12.083932708706442 -7.0023630498722005 23.510895291976862 0.9321118763635519 0.8344031840772004 0.09906734877928891 0.13645184080080994 117.02678867492322 1164372.3288885704 0.052814586856458554 0.04573118635154591 9.94573652690574e-08 7.0023630498722005 -0.09770869228635148 GAAS(ph)PVLQEDHCDSLPSVLQVEEK ddPTM_A459_Selumetinib_30min_R2 4 GAASPVLQEDHCDSLPSVLQVEEK 24 0 Q8N9B5-2;Q8N9B5 Q8N9B5-2 JMY Junction-mediating and -regulatory protein 1 GAAS(0.999)PVLQEDHCDS(0.001)LPSVLQVEEK;GAAS(1)PVLQEDHCDSLPSVLQVEEK;GAAS(1)PVLQEDHCDSLPSVLQVEEK;GAAS(1)PVLQEDHCDSLPSVLQVEEK 108.78 3.0054e-07 60932000.0 141381.0 98122.0 130189.0 133907.0 150321.0 121779.0 128723.0 130884.0 106325.0 125822.0 True False 133523.61001298518 105647.64188804242 121812.78147906574 115668.63559754068 131436.33209320932 138552.95185030418 134708.8745597857 131264.85077098745 127592.97096871892 122189.19193518398 1.0927612164242286 0.8646234598562847 0.9969194455732394 0.9466355719816678 1.0756788715235186 1.1339215003876977 1.1024614569121864 1.0742754632555203 1.044224689172193 1.0 16.89875715377424 -6.270622041313043 23.133889443344092 1.080117236898993 0.9688830012186156 0.3604137110613316 0.062170644790815854 221.39933049406017 557770.0919837197 0.018315624279869942 0.021095038332568473 5.362631546831964e-07 6.270622041313043 -0.11123423568037749 GAAS(ph)PVPPPLVR ddPTM_A459_Selumetinib_30min_R1 1 GAASPVPPPLVR 12 0 Q4G0W2 Q4G0W2 DUSP28 Dual specificity phosphatase 28 1 GAAS(1)PVPPPLVR 80.245 0.04051 4663200.0 1918.3 1946.3 2086.8 1863.2 2059.8 1747.4 1933.0 1880.7 1160.9 1772.7 True False 1962.9926576379703 1718.4262911896772 1803.4240219718904 1537.8270965956615 1873.4914536872263 1729.8227425122575 1787.192253732771 1830.8177266254409 1969.9625112186973 2000.2433125602408 0.9813769381512937 0.8591086296347379 0.901602325400889 0.7688200165145395 0.9366317797054516 0.8648061621554157 0.8934874285094987 0.915297511622253 0.9848614410299988 1.0 10.965959786898852 -8.179771377569777 1.909441038839281 1.001939627837207 0.8820521278878012 0.3934067910068598 0.05192014213474098 0.3350713538768722 2.188280886871915 0.04618763586036914 0.01397393084500703 6.610413435321369e-09 8.179771377569777 -0.11988749994940584 GAAS(ph)PVPPPLVR ddPTM_A459_Selumetinib_30min_R2 1 GAASPVPPPLVR 12 0 Q4G0W2 Q4G0W2 DUSP28 Dual specificity phosphatase 28 1 GAAS(1)PVPPPLVR 121.68 0.0037276 3206500.0 14410.0 13626.0 18527.0 19135.0 16112.0 14424.0 10889.0 14467.0 11708.0 12764.0 True False 13609.149887800475 14671.070385504427 17334.9929906724 16528.77999028385 14087.866516892445 16410.775071964683 11395.360076144156 14509.096574859223 14049.92714885269 12395.470155145247 1.0979131664603654 1.1835832124055898 1.39849418970823 1.3334532521481568 1.1365334546059715 1.3239332487241493 0.919316486871137 1.170516034749729 1.1334727100303406 1.0 13.597525372848445 -7.245751531015742 24.979459132324752 1.0700359648686846 1.2488088949674727 0.4234115716514315 0.1079748103528036 867.307807345732 1380999.1253836302 0.042594971868558665 0.03287624559105909 5.678694024866986e-08 7.245751531015742 0.17877293009878814 GAASFGSSTAS(ph)AALELSNR ddPTM_A459_Selumetinib_30min_R1 1 GAASFGSSTASAALELSNR 19 0 Q2TAZ0;H7C3T2;Q2TAZ0-3;Q2TAZ0-4 Q2TAZ0 ATG2A Autophagy-related protein 2 homolog A 1 GAAS(0.016)FGS(0.073)S(0.073)T(0.073)AS(0.761)AALELS(0.004)NR 72.428 0.012787 7217300.0 1885.1 2356.1 1279.2 2351.1 4871.7 1717.9 3940.5 2292.5 600.2 742.97 True False 1929.0191622339244 2080.2467166788274 1105.4916661426303 1940.5245206129562 4431.055595168494 1700.6194857284013 3643.2649124852505 2231.695452910525 1018.4955631264221 838.3374366406501 2.3010056308159244 2.481395468887448 1.3186714774095132 2.3147296491839167 5.285527523289941 2.028562022165026 4.3458215668912334 2.662049140800964 1.214899297838462 1.0 9.711387245371291 -6.014697088828496 24.942917868200507 2.965784850130037 2.034834279564708 0.0486356504751041 1.2637014266571673 1560.8587100102986 2648989.267652446 0.36132673218813843 0.4845821875923447 9.667249139826188e-07 6.014697088828496 -0.9309505705653289 GAASTLVPGVS(ph)ETSASPGSPSVR ddPTM_A459_Selumetinib_30min_R1 1 GAASTLVPGVSETSASPGSPSVR 23 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 GAASTLVPGVS(0.726)ET(0.193)S(0.025)AS(0.049)PGS(0.007)PSVR 291.7 9.903099999999995e-93 10105000.0 2528.9 3485.8 3413.8 3676.1 3174.7 3006.5 3284.3 2721.9 1370.8 2330.5 True False 2587.8184496171943 3077.680915495545 2950.2247106611276 3034.138143943381 2887.548945538809 2976.257339683589 3036.562606794901 2649.7063700227523 2326.147480729255 2629.6423759923505 0.984095203683591 1.1703800271830187 1.121911001129117 1.1538215886859464 1.0980766707674965 1.1318106853067562 1.1547435630478045 1.007629932576984 0.8845870077110523 1.0 11.360650895029814 -7.934582153125004 4.442080038468016 0.9422434439329281 1.119489061302882 0.6239199218346718 0.05557646838914262 0.11920313870723524 4.605744769425667 0.031520467220094425 0.013988766819703105 1.1625666137987421e-08 7.934582153125004 0.17724561736995392 GAASTLVPGVSET(ph)SASPGSPSVR ddPTM_A459_Selumetinib_30min_R1 1 GAASTLVPGVSETSASPGSPSVR 23 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 GAASTLVPGVS(0.111)ET(0.64)S(0.163)AS(0.032)PGS(0.054)PSVR 229.46 1.3884e-30 28257000.0 2183.7 2293.7 2951.0 2576.5 2285.1 2369.1 2329.9 1966.0 873.92 1538.4 True False 2234.575961259467 2025.1525376877996 2550.2704086826943 2126.5626418949773 2078.413108467173 2345.269004970694 2154.1537671867495 1913.8552935319913 1482.9784114086017 1735.8686252849727 1.287295552618576 1.1666508099686035 1.4691609558090972 1.2250711896736226 1.19733318420106 1.3510636524038089 1.2409658978847595 1.1025346421119853 0.8543148887002582 1.0 10.761442049943403 -7.945918495116322 2.686775995072992 0.9302952872893461 1.2794806440101918 0.7197624943343041 0.08765855309014532 0.14352985708181756 2.011570447541114 0.06272014073015288 0.023542667152337615 1.1326129029406876e-08 7.945918495116322 0.3491853567208457 GAASTLVPGVSET(ph)SASPGSPSVR ddPTM_A459_Selumetinib_30min_R2 1 GAASTLVPGVSETSASPGSPSVR 23 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 GAASTLVPGVS(0.053)ET(0.826)S(0.071)AS(0.04)PGS(0.01)PSVR 141.93 4.4591e-06 3603400.0 22241.0 20612.0 28751.0 28598.0 28126.0 21482.0 21191.0 22768.0 16922.0 23849.0 True False 21004.93425777725 22192.874121973964 26901.19196172192 24702.90306569832 24592.560430369744 24440.950505819834 22176.423489169905 22834.251110554695 20306.872840184922 23160.417402856394 0.9069324568902931 0.9582242727299422 1.1615158524044638 1.0666000804740112 1.0618358038459499 1.0552897247355097 0.9575139818695525 0.9859170805677504 0.8767921789561728 1.0 14.499373633723083 -7.270677980708109 21.036463801733582 0.9538821505477403 1.0399713908298487 0.23442457335163935 0.07048825814333215 121.12856589655271 275804.7935245488 0.030967122744989653 0.021308479381324064 5.361940856394092e-08 7.270677980708109 0.0860892402821084 GAASTLVPGVSETS(ph)ASPGSPSVR ddPTM_A459_Selumetinib_30min_R1 2 GAASTLVPGVSETSASPGSPSVR 23 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 GAASTLVPGVS(0.003)ET(0.05)S(0.905)AS(0.036)PGS(0.006)PSVR;GAASTLVPGVS(0.006)ET(0.106)S(0.532)AS(0.326)PGS(0.03)PSVR 243.99 1.5297e-37 35749000.0 7296.6 9427.7 9495.4 10514.1 9358.0 7484.4 8587.2 7835.1 4311.2 7380.5 True False 7466.596583287921 8323.900501181179 8205.976834498695 8678.009809100702 8511.570552289088 7409.113731291486 7939.460590405619 7627.287696008397 7315.791522410247 8327.859067157926 0.8965805644734655 0.9995246598261541 0.9853645178579101 1.0420457093616826 1.0220598696075025 0.889678087914619 0.9533615454320054 0.9158761735159124 0.8784720614762913 1.0 13.023729938694137 -6.759143310316363 24.994879827590978 0.9238375822715684 0.9924256034778375 0.2933539580095187 0.04752635588113328 73.28904529086715 797824.1542759467 0.016045034465483027 0.015325819614623232 1.7412321994690737e-07 6.759143310316363 0.06858802120626906 GAASTLVPGVSETS(ph)ASPGSPSVR ddPTM_A459_Selumetinib_30min_R2 3 GAASTLVPGVSETSASPGSPSVR 23 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 1 GAASTLVPGVS(0.216)ET(0.216)S(0.268)AS(0.268)PGS(0.03)PS(0.004)VR;GAASTLVPGVS(0.057)ET(0.057)S(0.441)AS(0.441)PGS(0.003)PS(0.001)VR;GAASTLVPGVS(0.006)ET(0.164)S(0.543)AS(0.286)PGS(0.002)PSVR 237.14 6.077999999999999e-37 46736400.0 121591.0 107186.9 122082.0 140669.0 150043.0 105199.0 112536.0 120357.0 101882.0 130928.0 True False 114833.45898733847 115407.790569795 114227.37703283147 121509.63953244011 131193.2569385611 119689.20734855885 117769.14698585363 120707.21894382608 122261.24682092643 127147.76844820245 0.9031496218049584 0.9076666620131042 0.8983828692154003 0.9556568787280038 1.0318172197572362 0.9413394258454322 0.9262384108127742 0.9493459493392515 0.9615681683845935 1.0 16.956146616158392 -5.806547457795288 5.702771297167728 0.964891292310072 0.9034240245449702 0.5119567756265005 0.028454288020247822 0.1669574746106513 12.662685305323 0.008564251095815463 0.013155700144723921 1.5611784299198365e-06 5.806547457795288 -0.06146726776510181 GACST(ph)PDMPQFEPVK ddPTM_A459_Selumetinib_30min_R1 5 GACSTPDMPQFEPVK 15 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GACS(0.149)T(0.851)PDMPQFEPVK;GACS(0.325)T(0.675)PDMPQFEPVK;GACS(0.045)T(0.955)PDMPQFEPVK;GACS(0.024)T(0.976)PDMPQFEPVK;GACS(0.226)T(0.774)PDMPQFEPVK 244.71 2.5812e-20 64312300.0 16170.8 24787.0 10730.05 10478.33 14608.6 15176.3 21468.300000000003 19305.2 9237.54 21407.2 True False 16547.548177100613 21884.926516836324 9272.968145945697 8648.48636811465 13287.254709357807 15023.640200977894 19848.928846772505 18793.163383872732 15675.43069677249 24155.02264378606 0.6850562063686374 0.9060197061113614 0.3838939951617554 0.35804091329798426 0.5500824778889615 0.6219675478069885 0.8217309144969356 0.7780230083413862 0.6489511903150724 1.0 14.560035584754237 -7.156671415441892 4.038304674898803 0.7936726182593893 0.5732214441507534 0.3148154296932769 0.164626142189163 0.34797449789283724 9.947560059590142 0.07141886376142298 0.05414066669268232 6.971537769223699e-08 7.156671415441892 -0.2204511741086359 GACST(ph)PDMPQFEPVK ddPTM_A459_Selumetinib_30min_R2 10 GACSTPDMPQFEPVK 15 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GACS(0.083)T(0.917)PDMPQFEPVK;GACS(0.162)T(0.838)PDMPQFEPVK;GACS(0.291)T(0.709)PDMPQFEPVK;GACS(0.091)T(0.909)PDMPQFEPVK;GACS(0.169)T(0.831)PDMPQFEPVK;GACS(0.091)T(0.909)PDMPQFEPVK;GACS(0.15)T(0.85)PDMPQFEPVK;GACS(0.026)T(0.974)PDMPQFEPVK;GACS(0.055)T(0.945)PDMPQFEPVK;GACS(0.013)T(0.987)PDMPQFEPVK 281.93 6.1919e-55 197129000.0 977914.0 563160.4 808009.0 879605.0 845259.0 732299.0 1147992.0 1065554.0 906784.0 602265.0 True False 923565.4547799107 606352.991833908 756022.5806336831 759801.2815967404 739070.0077086634 833166.5401015426 1201375.902702992 1068654.5857280404 1088166.1376618745 584876.044577606 1.579078957571094 1.036720511047452 1.292620184469477 1.2990808713074653 1.2636352857337751 1.424518148462125 2.054069257650343 1.827147129097784 1.8605072779955307 1.0 19.157771374650885 -7.053132935172012 6.747081121417242 1.7546516215756942 1.2856813121083512 0.280865319657038 0.28715851250119173 0.247341759805635 25.664441797277213 0.10285245942861382 0.08037805396603338 8.848447222313338e-08 7.053132935172012 -0.46897030946734297 GACST(ph)PDMPQFEPVKTETMTVSSLAIR ddPTM_A459_Selumetinib_30min_R1 2 GACSTPDMPQFEPVKTETMTVSSLAIR 27 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GACS(0.126)T(0.874)PDMPQFEPVKTETMTVSSLAIR;GACS(0.198)T(0.802)PDMPQFEPVKTETMTVSSLAIR 191.92 2.6966e-32 132699000.0 4069.6000000000004 4867.799999999999 4006.6000000000004 4623.6 4813.6 3798.9 4487.9 4616.5 2160.06 3823.5 True False 4164.413761936867 4297.875713021176 3462.525726678443 3816.175055721175 4378.210729910106 3760.686515125221 4149.3740897709795 4494.055423494629 3665.464055459609 4314.283469043872 0.9652619703405304 0.9961968757638606 0.8025726059780223 0.8845443474225193 1.0148175847333465 0.8716827584717471 0.9617759517991432 1.0416690177501475 0.8496113159369999 1.0 12.074905256234226 -7.489083118195385 24.28412366696569 0.9677286091884426 0.9223674323406917 0.06726789573053782 0.07392455801555464 1244.127925061622 893980.9199604557 0.031105519896037503 0.02095528353718379 3.2427754899429974e-08 7.489083118195385 -0.04536117684775087 GACST(ph)PDMPQFEPVKTETMTVSSLAIR ddPTM_A459_Selumetinib_30min_R2 1 GACSTPDMPQFEPVKTETMTVSSLAIR 27 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GACS(0.223)T(0.777)PDMPQFEPVKTETMTVSSLAIR 71.903 0.00061203 7641200.0 11065.0 8186.0 10246.0 10149.0 6566.7 8486.4 9592.3 6788.2 4561.5 9078.4 True False 10450.05159670453 8813.839877861386 9586.783515001322 8766.688691998474 5741.73243895715 9655.324568130969 10038.360956781857 6807.952538152997 5473.927458958962 8816.283003484072 1.1853126303426076 0.999722884845947 1.0873951654243357 0.9943746915263497 0.6512645336689054 1.0951695362223877 1.1386160077682212 0.7722021327426296 0.6208883558746632 1.0 13.10595481995613 -1.522908215147817 0.3470887202337955 0.8630290872528399 4.410595591164881 0.23049854747845444 0.1680058683149964 101.47925833359463 1.431560092339139 0.15268778845233266 234.9309009219633 0.029997964362740253 1.522908215147817 3.5475665039120416 GADAGSSGGTGPT(ph)EGYSPPAASTR ddPTM_A459_Selumetinib_30min_R2 1 GADAGSSGGTGPTEGYSPPAASTR 24 0 J3KT76;J3KSI9;Q969W3;Q969W3-2 J3KT76 FAM104A Protein FAM104A 1 GADAGSSGGTGPT(0.571)EGY(0.001)S(0.427)PPAASTR 172.55 7.7661e-16 6188200.0 16066.0 16604.0 17466.0 17062.0 19745.0 13080.0 16918.0 16821.0 13676.0 14489.0 True False 15173.116037293707 17877.473409725182 16342.256575542933 14738.126166408318 17264.456577460373 14881.651271581943 17704.720522381016 16869.946325133544 16411.58213936704 14070.664923056991 1.0783510317575806 1.2705492958211333 1.1614416706607507 1.047436368288295 1.2269822834861097 1.0576366755202893 1.2582717745889218 1.1989445003049921 1.166368627858808 1.0 13.780402885702477 -10.559314298447612 4.210884136280339 0.99998969027452 1.1652708585891027 0.29220866659467004 0.07597100920345387 10117223.6283184 8462056.307901114 1148.4670273644651 0.017646805948749032 2.7585807517449483e-11 10.559314298447612 0.16528116831458273 GADAGSSGGTGPTEGYS(ph)PPAASTR ddPTM_A459_Selumetinib_30min_R1 4 GADAGSSGGTGPTEGYSPPAASTR 24 0 J3KT76;J3KSI9;Q969W3;Q969W3-2 J3KT76 FAM104A Protein FAM104A 1 GADAGSSGGTGPTEGYS(1)PPAASTR;GADAGSSGGTGPTEGYS(0.999)PPAAS(0.001)TR;GADAGSSGGTGPTEGYS(1)PPAASTR;GADAGSSGGTGPT(0.003)EGY(0.009)S(0.989)PPAASTR 308.69 3.8640999999999983e-131 37529000.0 3874.75 4478.349999999999 4201.71 4923.72 4512.7 3711.47 3982.3100000000004 3869.65 2466.89 3235.87 True False 3965.0241360489654 3954.022700071568 3631.140860340959 4063.884731671312 4104.527081781895 3674.1359815451324 3681.921150523827 3767.014311605324 4186.1321554830665 3651.2254345429583 1.085943392740768 1.0829303122902112 0.9944992237367799 1.1130193970562128 1.1241505503742413 1.0062747555342448 1.0084069626844914 1.0317123330613684 1.1465006011076566 1.0 11.834165031292091 -6.775048237141176 24.99567954328809 1.0386752147335296 1.0773376526094323 0.14319844939693338 0.05056551067737356 548.3423379429863 1007145.8692348092 0.018366542965075443 0.0162864506413646 1.678617563510077e-07 6.775048237141176 0.03866243787590262 GADAGSSGGTGPTEGYS(ph)PPAASTR ddPTM_A459_Selumetinib_30min_R2 2 GADAGSSGGTGPTEGYSPPAASTR 24 0 J3KT76;J3KSI9;Q969W3;Q969W3-2 J3KT76 FAM104A Protein FAM104A 1 GADAGSSGGTGPT(0.259)EGYS(0.741)PPAASTR;GADAGSS(0.005)GGTGPT(0.007)EGYS(0.987)PPAASTR 248.9 2.0534e-52 24200900.0 26642.6 22185.4 29654.4 29947.1 29614.6 23902.3 22830.2 21202.3 19273.3 29904.8 True False 25161.910950778136 23886.948842695576 27746.468189269468 25868.253318371022 25894.149190116877 27194.624861523924 23891.84953718307 21263.99518277028 23128.49854099611 29041.37072199841 0.8664160928092268 0.8225145111556861 0.9554117970145234 0.8907380290688621 0.8916297181008209 0.9364098245171464 0.822683259887776 0.7321966785356697 0.7963983092394675 1.0 14.825821928170994 -7.3643913079262155 7.349252523435869 0.8145946387412083 0.8930466685482003 0.092736736561567 0.07278784457257861 0.4372863204006203 27.502774313037033 0.02964596208868504 0.019894213977688133 4.3212430302305624e-08 7.3643913079262155 0.07845202980699195 GADDDRPSWR ddPTM_A459_Selumetinib_30min_R1 1 GADDDRPSWR 10 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 128.35 0.0088288 27619000.0 4964.1 6128.5 4455.1 4684.8 5006.2 4904.7 5776.0 5174.3 2836.6 4510.2 False True 5079.753871542853 5410.972370937644 3850.1218901125994 3866.68762458746 4553.390093916396 4855.363171111288 5340.311669715719 5037.060755504877 4813.503022933036 5089.128103068311 0.998157988689692 1.063241533982076 0.7565386078199335 0.759793730139388 0.8947289204944732 0.9540658188941867 1.0493568960262496 0.9897689060858889 0.9458404122370005 1.0 12.313202791822217 -6.8970819994847306 3.774559647827371 0.996101681117885 0.8888461847380018 0.21792133943487935 0.09062227742585732 0.3972651540779409 10.783817248220883 0.037614424665629906 0.03280607176401513 1.267412542100285e-07 6.8970819994847306 -0.10725549637988319 GADFLVTEVENGGS(ph)LGSK ddPTM_A459_Selumetinib_30min_R1 2 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 GADFLVTEVENGGS(0.986)LGS(0.014)K;GADFLVT(0.332)EVENGGS(0.668)LGSK 211.89 8.439e-12 9165300.0 3208.89 4060.1 4206.5 4507.0 5303.3 3396.44 4745.4 5708.5 1901.72 3412.08 True False 3283.650893586981 3584.7416045107193 3635.280404650545 3719.937056868097 4823.6174513736605 3362.2748973207795 4387.4506574565385 5557.092036178727 3227.079943866674 3850.0537044737093 0.8528844389291048 0.9310887275014629 0.9442155054685079 0.9662039395828639 1.2528701731533467 0.8733059732163898 1.1395816770967069 1.4433803948556516 0.8381908907184468 1.0 11.910662854791058 -6.04821798676406 9.521866904167224 1.1054760738123102 0.9186988105452668 0.1970148068071227 0.16693567971977968 0.7965090468696902 153.77870213879794 0.048410219125151796 0.0628750643664818 8.949154651298156e-07 6.04821798676406 -0.18677726326704336 GADFLVTEVENGGSLGS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 GADFLVTEVENGGS(0.47)LGS(0.53)K 186.98 1.9199e-10 3117100.0 1289.0 1692.3 2076.5 1932.5 1935.8 1654.5 1728.4 2282.7 761.53 1703.5 True False 1319.0311920426138 1494.164729271075 1794.5227053980395 1595.025152517773 1760.7072317932484 1637.8572321658057 1598.0253964571766 2222.1553807454097 1292.2607900494224 1922.160818495159 0.6862231189767308 0.7773359621599414 0.9335965482861907 0.8298083787632831 0.9160041214302188 0.8520916753719224 0.8313692491704493 1.1560715208445012 0.6722958753581924 1.0 10.908513329587215 -5.0272740121115165 2.93373929440084 0.8985788237094517 0.6880725285788787 0.25433220135721857 0.11889313636926532 0.3657313877199945 5.902107236868894 0.029118351492237807 0.13814108148958648 9.391305921103667e-06 5.0272740121115165 -0.21050629513057306 GADFLVTEVENGGSLGS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 GADFLVTEVENGGS(0.077)LGS(0.923)K 212.92 6.2841e-12 1571300.0 9889.7 8766.6 11025.0 9392.6 10890.0 7148.4 8112.3 7449.5 6948.5 9278.8 True False 9340.070065605853 9438.97003093814 10315.663503112382 8113.311676861257 9521.900842164767 8133.027213285659 8489.538024217494 7471.176811668888 8338.394157311483 9010.896934782333 1.0365305621855356 1.047506158294124 1.1447987450942438 0.9003889108467804 1.056709549679782 0.9025768768802503 0.9421412857856161 0.8291268744657284 0.9253678316000964 1.0 13.137455002128037 -6.370363658896541 1.0309895339630417 0.9079103860025011 1.0649040581467464 0.39375707994581666 0.06993975719895673 0.4821341122330648 1.0876069785339257 0.03173006129830021 0.043362089859861355 4.262224695816907e-07 6.370363658896541 0.1569936721442453 GADFLVTEVENGGSLGSK ddPTM_A459_Selumetinib_30min_R2 4 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ;;; 199.33 2.2074e-13 9692300.0 84368.0 67412.0 81328.0 90130.0 78394.0 61150.5 78638.0 84748.0 62307.6 69769.0 False True 79679.16431186341 72582.28363625605 76095.44502323118 77854.13851707794 68545.444868748 69573.42630602999 82294.82281824076 84994.60264921344 74770.861019803 67754.58768836793 1.1759965934460654 1.0712526798936883 1.123103949406738 1.1490607672968527 1.0116723783194956 1.026844508685193 1.2146014849466658 1.2544479355426033 1.1035542178148272 1.0 16.048031014741824 -7.268856621821001 24.93302435338273 1.1643548998074265 1.0922219272302982 0.06231684909514079 0.07984699706964773 1088.5479134353411 3659134.3503842293 0.03276156610872006 0.02259013661283336 5.384475164855855e-08 7.268856621821001 -0.07213297257712825 GADNDGS(ph)GS(ph)ESGYTTPK ddPTM_A459_Selumetinib_30min_R2 1 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 2 GADNDGS(1)GS(0.967)ES(0.033)GYTTPK 121.26 0.026104 4743600.0 29190.0 30292.0 33181.0 35236.0 32301.0 27802.0 26736.0 25820.0 21111.0 28784.0 True False 27567.7366568283 32615.29899586818 31046.170584741227 30436.796014509608 28243.059605396174 31631.473138571975 27979.27697637894 25895.131925268885 25333.789890624284 27952.93113018654 0.9862198897294794 1.1667935231538822 1.1106588586416357 1.0888588346157635 1.0103791789797787 1.131597720155113 1.0009425074626235 0.9263834194942289 0.906301731744553 1.0 14.770711950820615 -7.501213492898712 4.004697809424579 0.9392556055424013 1.0842867452920582 0.5657223746916006 0.054744122233199216 0.15055633760326978 5.440150941690839 0.02535597299204175 0.01529164424527659 3.153454049792026e-08 7.501213492898712 0.14503113974965687 GADNDGS(ph)GSESGYTTPK ddPTM_A459_Selumetinib_30min_R1 3 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGS(0.5)GS(0.5)ESGYTTPK;GADNDGS(0.891)GS(0.108)ES(0.001)GYTTPK;GADNDGS(0.494)GS(0.494)ES(0.013)GYTTPK 256.79 5.0795e-40 289370300.0 9064.5 9321.900000000001 10915.7 10588.099999999999 9829.6 7828.0 9005.4 9453.900000000001 4759.200000000001 7861.9 True False 9275.685213553346 8230.487614366266 9433.407895648153 8739.087098252747 8940.514415556829 7749.257427255321 8326.115427710862 9203.15186140493 8076.014801784844 8871.05144639101 1.0456128306331662 0.927791667549697 1.0633923106697714 0.9851241593022269 1.007830297184679 0.8735444128675338 0.9385714284295079 1.0374364208144715 0.9103785329833017 1.0 13.11488939556879 GADNDGS(ph)GSESGYTTPK ddPTM_A459_Selumetinib_30min_R2 5 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGS(0.986)GS(0.014)ESGYTTPK;GADNDGS(0.996)GS(0.004)ESGYTTPK;GADNDGS(0.989)GS(0.007)ES(0.004)GYTTPK;GADNDGS(0.997)GS(0.002)ES(0.001)GYTTPK;GADNDGS(0.99)GS(0.009)ESGYTTPK 185.09 5.8881e-08 605559400.0 665058.0 653715.0 729079.0 754115.0 783238.0 540153.0 628124.0 663093.0 504081.0 698074.0 True False 628096.7387981132 703852.8384749761 682170.8509011953 651403.2360790634 684840.6402034394 614554.1727292665 657333.010604093 665022.4908490443 604911.2851999312 677918.7898059265 0.9265073460759565 1.0382553914407269 1.0062722278231675 0.9608868287388023 1.0102104418723878 0.9065306670511376 0.9696338565748756 0.9809766314921377 0.8923064153054443 1.0 19.370752932810866 -6.738125491318217 24.999896772881687 0.9499345435139179 0.9906561740286723 0.17863918383831623 0.04117806630236444 391.028471922044 419305.6431221338 0.013049642579736013 0.013042364485905018 1.827572054781992e-07 6.738125491318217 0.040721630514754414 GADNDGSGS(ph)ESGYTTPK ddPTM_A459_Selumetinib_30min_R1 3 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGS(0.368)GS(0.619)ES(0.012)GYTTPK;GADNDGS(0.147)GS(0.852)ES(0.001)GYTTPK;GADNDGS(0.187)GS(0.797)ES(0.015)GYT(0.001)TPK 197.38 7.6547e-08 303838200.0 20707.8 22590.2 25041.0 24022.4 23018.3 19663.4 22413.3 19885.6 12316.0 18555.4 True False 21190.251449635394 19945.328882100945 21640.569740367126 19827.33879629648 20936.29882921093 19465.604048938723 20722.646735948634 19358.16929046783 20899.352474950032 20937.16633490173 1.0120878399056217 0.9526279040374525 1.0335959219224828 0.9469924668480475 0.9999585662320811 0.9297153080591452 0.9897541245304291 0.9245840139407141 0.9981939361159555 1.0 14.353778578684556 -5.790032179209941 24.999111755171064 0.9671503103987465 0.9947563987521301 0.13672787868166236 0.03291418344954137 396.059058019117 346278.6569936772 0.008536358103239576 0.012664049826927745 1.621689933192991e-06 5.790032179209941 0.027606088353383518 GADNDGSGS(ph)ESGYTTPK ddPTM_A459_Selumetinib_30min_R2 1 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGS(0.111)GS(0.884)ES(0.005)GYTTPK 191.97 8.0884e-08 5950700.0 29397.0 27937.0 32240.0 32951.0 34775.0 21252.0 25464.0 26533.0 22848.0 24962.0 True False 27763.23242551494 30079.67806838667 30165.713500257887 28463.016956354488 30406.25360755556 24179.270093551946 26648.126455958776 26610.20663722539 27418.23842645934 24241.28220093512 1.1452872911336331 1.240845175558673 1.2443943043200179 1.1741547629545979 1.2543170511988275 0.997441880059431 1.099287002852135 1.097722736638035 1.1310556182297018 1.0 14.565178389251733 -6.752625686879875 24.999999791222358 1.073345711651563 1.21313278756714 0.6787189223743683 0.050301434587426475 116.6403690469561 330849.29661078274 0.016369378356939475 0.016135511286022062 1.7675606032963357e-07 6.752625686879875 0.13978707591557704 GADNDGSGS(ph)ESGYTTPKK ddPTM_A459_Selumetinib_30min_R1 1 GADNDGSGSESGYTTPKK 18 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGS(0.028)GS(0.967)ES(0.005)GYTTPKK 124.4 0.00044491 6940300.0 1616.1 998.33 3053.2 3113.3 2116.5 1286.0 1505.4 1721.8 875.11 1306.8 True False 1653.75198561681 881.4450594889745 2638.59221002711 2569.6205988789548 1925.062948698425 1273.0640075945762 1391.846465995507 1676.1322708053833 1484.99775449444 1474.540509309935 1.1215371671211283 0.597776089516509 1.7894335173347902 1.7426585316950718 1.3055341216765408 0.8633631965732518 0.943918771446213 1.1367149700009194 1.0070918670043176 1.0 10.52604974204157 -6.740527901304492 20.50551436209389 0.9958692652912857 1.3222617938689072 0.20442502734495305 0.31633365848418177 56.53245808559349 55433.03581715502 0.11530761911098483 0.11503484164573423 1.8174902874488434e-07 6.740527901304492 0.32639252857762147 GADNDGSGS(ph)ESGYTTPKK ddPTM_A459_Selumetinib_30min_R2 1 GADNDGSGSESGYTTPKK 18 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGS(0.103)GS(0.769)ES(0.129)GYTTPKK 70.453 0.01214 3243800.0 21380.0 25585.0 25464.0 31964.0 22906.0 14560.0 11863.0 16150.0 13189.0 21745.0 True False 20191.78519092118 27547.287231258677 23825.673963106932 27610.448059024457 20028.343497761816 16565.50783747959 12414.65300608854 16196.993826223572 15827.16853145013 21117.165349704912 0.956178770045163 1.3044973970260463 1.128260993772058 1.307488367959873 0.9484390147109252 0.784456983839977 0.5878939147607717 0.7670060615616625 0.7494930436613405 1.0 14.366128567920564 -6.543848356124734 3.1704492229152774 0.7518726254694429 1.1792262876369428 0.6599310575183948 0.13296498648193178 0.13682819680540753 2.8481711153833444 0.04359827762083188 0.045750283078541024 2.8585885108495646e-07 6.543848356124734 0.4273536621674999 GADNDGSGSESGYT(ph)TPK ddPTM_A459_Selumetinib_30min_R2 1 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGSGSESGY(0.035)T(0.747)T(0.218)PK 111.7 0.0046761 54670000.0 81316.0 73486.0 73408.0 72833.0 68300.0 54190.0 65220.0 63354.0 60509.0 75713.0 True False 76796.78225373925 79122.13990526764 68685.00920058717 62913.01975606715 59719.54339025281 61654.180612157914 68252.85923097837 63538.34965118071 72612.49076272009 73526.96896400125 1.044470938157928 1.0760968528976869 0.9341471594486004 0.8556454950137998 0.8122127735129603 0.8385247138685094 0.9282697246012537 0.8641502641335459 0.9875626832689256 1.0 16.165985892821134 -5.379593521899703 3.738496966397369 0.8879172497370087 1.0605889092434801 0.5344499642775933 0.058939743197081174 0.162454947671926 4.001273290871762 0.015856640784766948 0.03637374832447487 4.172597351889644e-06 5.379593521899703 0.17267165950647145 GADNDGSGSESGYT(ph)TPKK ddPTM_A459_Selumetinib_30min_R1 1 GADNDGSGSESGYTTPKK 18 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGSGS(0.002)ES(0.16)GY(0.003)T(0.418)T(0.418)PKK 71.946 0.025901 6892900.0 1586.8 1337.7 1663.8 2045.2 1561.1 1348.4 1174.0 1205.1 923.69 1376.5 True False 1623.7693526246837 1181.0814621201416 1437.86509859921 1688.0442131587827 1419.8987806345904 1334.8363202492435 1085.4442348071773 1173.1368332835207 1567.4344663516238 1553.187183245427 1.0454434405206547 0.7604244194522902 0.9257513286935266 1.0868259997044067 0.9141839412218643 0.8594175477678528 0.6988495955388403 0.7553093702667694 1.009172933732576 1.0 10.60101599208643 -6.7336766930716365 4.140477659865918 0.837773876944188 0.9447099234266662 0.08719938625945667 0.12124973724682424 0.4407866321537861 16.694442168804144 0.043115597019448504 0.041163415105638576 1.8463894369945842e-07 6.7336766930716365 0.10693604648247812 GADNDGSGSESGYTT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGSGSESGYT(0.099)T(0.901)PK;GADNDGSGSESGYT(0.093)T(0.907)PK 217.65 2.1324e-11 79335000.0 5898.9 6277.4 7121.4 7552.1 4864.299999999999 5368.5 5041.9 4673.1 3323.1 4694.6 True False 6036.3328927386865 5542.43908971591 6154.352995050137 6233.267505474504 4424.3249238619155 5314.497764207994 4661.585423743021 4549.15420763192 5639.057990378896 5297.197639276413 1.1395332596205034 1.046296450904746 1.1618129837969968 1.176710391029691 0.8352199077975633 1.0032659013519354 0.8800097223443951 0.8587850628607707 1.0645360763147174 1.0 12.371013621480266 -6.252523902033457 24.995545560822187 0.933375533789364 1.1272263409986403 0.6130546685829583 0.07410720370962763 428.8179634391939 1202239.0464745627 0.021449099849020912 0.027270959553530854 5.590827567847144e-07 6.252523902033457 0.19385080720927628 GADNDGSGSESGYTT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GADNDGSGSESGYTTPK 17 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGSGSESGY(0.018)T(0.129)T(0.853)PK 105.9 0.006096 61643000.0 129510.0 115470.0 117210.0 120620.0 110040.0 97033.0 119060.0 97693.0 84281.0 117140.0 True False 122312.35266960727 124326.17770543032 109668.83620859882 104191.34791889394 96215.79142991833 110398.4149721263 124596.52591291418 97977.2704560532 101139.55500789669 113757.8638337288 1.0751990987487416 1.0929018312716245 0.9640549893666551 0.9159045749240026 0.8457946394857556 0.9704684252289341 1.0952783545147036 0.861279098904838 0.8890774808827693 1.0 16.795606753566013 -5.32710811648396 4.114555011309223 0.9380372806234466 1.0853116653705612 0.40580066800319636 0.06873657243273507 0.21557455945492185 7.2028572413550815 0.01939575464318066 0.04500667872630781 4.708600924072288e-06 5.32710811648396 0.14727438474711463 GADNDGSGSESGYTT(ph)PKK ddPTM_A459_Selumetinib_30min_R2 2 GADNDGSGSESGYTTPKK 18 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 GADNDGSGSES(0.005)GY(0.002)T(0.069)T(0.923)PKK;GADNDGS(0.001)GS(0.001)ES(0.003)GY(0.001)T(0.024)T(0.97)PKK 92.034 0.00642 14749600.0 34842.0 34304.0 32932.0 35460.0 31708.0 26519.0 28885.0 29042.0 22373.5 36031.0 True False 32905.62112357696 36935.006495254915 30813.19097365052 30630.286828088076 27724.55756688342 30171.75153448637 30228.20973454165 29126.507411838083 26848.82516782162 34990.69141021925 0.9404107148899226 1.0555666380592814 0.8806110920303601 0.8753838690693121 0.7923409469635769 0.8622793754133855 0.8638928959749939 0.8324073128583993 0.7673133649476914 1.0 15.094683551821962 -5.414228383073493 4.7331818460372705 0.8490160298693137 0.9968457916940086 0.429360175937465 0.06393029180883263 0.17869643311361338 6.230372830623356 0.01596839903810512 0.034388187594245355 3.852756988897315e-06 5.414228383073493 0.14782976182469487 GADS(ph)GEEKEEGINR ddPTM_A459_Selumetinib_30min_R1 2 GADSGEEKEEGINR 14 1 Q9BVG4 Q9BVG4 PBDC1 Protein PBDC1 1 GADS(1)GEEKEEGINR;GADS(1)GEEKEEGINR 260.29 4.0563000000000005e-35 378800000.0 10121.900000000001 13591.2 7820.4 9118.1 9472.6 11087.2 12552.5 12671.3 6894.1 13423.699999999999 True False 10357.720576211117 11999.935985622538 6758.432634382289 7525.795002935216 8615.805002523359 10975.672834372155 11605.654818924268 12335.215961816843 11698.78417485816 15146.76265291075 0.6838240496374766 0.7922442742784058 0.446196510056459 0.4968583172120272 0.5688215495254797 0.724621695465926 0.7662135523523248 0.8143796958121865 0.7723620184019988 1.0 13.8867218561735 -7.979381224240776 0.6765744410967093 0.9700728993364758 0.5980951337083648 0.5841632607354297 0.1008410990920939 0.5395562789555151 0.5177016572266443 0.10699585603937249 0.05015195058994612 1.0486215432287517e-08 7.979381224240776 -0.371977765628111 GADS(ph)GEEKEEGINR ddPTM_A459_Selumetinib_30min_R2 2 GADSGEEKEEGINR 14 1 Q9BVG4 Q9BVG4 PBDC1 Protein PBDC1 1 GADS(1)GEEKEEGINR;GADS(1)GEEKEEGINR 222.75 2.1506e-08 119352000.0 159907.0 121870.0 123498.0 130502.0 119934.0 109886.0 141955.0 126079.0 102725.0 111195.0 True False 151020.00909843913 131217.03712618668 115552.27313445554 112727.40247149303 104866.81869643617 125021.7990542091 148556.18877849635 126445.86901649802 123272.87037631466 107984.51143069378 1.3985339850832796 1.2151468334456828 1.0700819182630545 1.0439219567506524 0.9711283341198558 1.1577752901577012 1.3757175618083166 1.1709630144287224 1.1415791833760642 1.0 16.72046487122759 -1.5229210010990542 0.013135557143282255 2.2799322617324557e-06 2.5129137100783976 0.12597490093981356 0.12868485812667313 24150.66078794407 24.59395875838112 1934.8639915076067 2852.2868257239757 0.02999708121344972 1.5229210010990542 2.512911430146136 GADS(ph)GEEKEEGINREDK ddPTM_A459_Selumetinib_30min_R1 1 GADSGEEKEEGINREDK 17 2 Q9BVG4 Q9BVG4 PBDC1 Protein PBDC1 1 GADS(1)GEEKEEGINREDK 84.208 0.014044 113010000.0 2084.6 3018.1 2618.5 2442.7 1932.8 2355.9 2383.8 2088.8 1494.7 2703.6 True False 2133.1671240745018 2664.7394489233757 2262.922082390931 2016.1283001579118 1757.9785812635557 2332.201784986053 2203.988046791609 2033.3982386213745 2536.3967314312918 3050.6333952941086 0.6992538426167872 0.8735036642010112 0.7417876188865247 0.6608884250949265 0.5762667464322014 0.7644975592884073 0.7224689961735389 0.666549524357166 0.8314328215720461 1.0 11.574893101560091 -8.56356623953433 3.7218637182988763 0.9997493098074651 0.7157829964326919 0.5985322411745457 0.07305801387078384 0.17329783022529924 7.079695059364974 0.07555779559409763 0.019864282310568866 2.731704766579764e-09 8.56356623953433 -0.2839663133747732 GADS(ph)GEEKEEGINREDK ddPTM_A459_Selumetinib_30min_R2 3 GADSGEEKEEGINREDK 17 2 Q9BVG4 Q9BVG4 PBDC1 Protein PBDC1 1 GADS(1)GEEKEEGINREDK;GADS(1)GEEKEEGINREDK;GADS(1)GEEKEEGINREDK 90.581 0.010064 156015000.0 277064.0 244217.0 237767.0 211582.0 197818.0 168752.0 219279.0 207291.0 146056.0 206956.0 True False 261665.8920550693 262947.6586185772 222469.330081136 182764.1666006916 172966.33432464188 191996.05622186497 229475.90799309537 207894.1824911278 175271.281145612 200980.64254373574 1.3019457433475352 1.3083233056206232 1.1069191901539674 0.9093620374953273 0.8606119083682519 0.9552962603355415 1.1417811441375938 1.0343990339561562 0.8720804099701838 1.0 17.61669702931861 -5.432862679334511 3.074589470301134 0.9720406886395183 1.307047282268064 0.7444433939063578 0.07845872094363299 0.13833596575813875 2.488053284601643 0.023926337168000467 0.05606090357631372 3.6909428497258623e-06 5.432862679334511 0.3350065936285458 GADS(ph)GEEKEEGINREDKTDK ddPTM_A459_Selumetinib_30min_R1 1 GADSGEEKEEGINREDKTDK 20 3 Q9BVG4 Q9BVG4 PBDC1 Protein PBDC1 1 GADS(1)GEEKEEGINREDKTDK 81.594 0.015178 8039000.0 756.27 1048.7 1260.2 1738.4 921.32 913.99 1117.0 1001.9 646.5 793.56 True False 773.8896195547457 925.917716472597 1089.0717617831015 1434.8210738095197 837.9867686722573 904.7960904365212 1032.7437906981404 975.3263573701436 1097.063281508217 895.4211559289804 0.8642744416194318 1.0340583426488033 1.216267623979928 1.6023980049040982 0.9358576834192217 1.0104698604064302 1.153360945137253 1.089237562583903 1.2251924965632928 1.0 9.806422594673831 -10.807591323313519 15.914343299133506 1.0000000121807828 1.1304411966077779 0.03613965619060355 0.19331335412186237 0.0 0.0 0.19484331031330768 0.04725644405098628 1.557430504376529e-11 10.807591323313519 0.13044118442699504 GADSELSTVPS(ph)VTK ddPTM_A459_Selumetinib_30min_R1 1 GADSELSTVPSVTK 14 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GADSELS(0.002)T(0.004)VPS(0.89)VT(0.104)K 100.4 0.013415 0.0 1774.5 2448.5 2588.9 2833.9 1941.2 2087.7 2153.2 1934.7 1465.6 1450.6 True False 1815.8423974240634 2161.828481723232 2237.341599809768 2339.0125638913914 1765.6188027466965 2066.6996334799346 1990.7823904487352 1883.3854712087207 2487.0161568112026 1636.7986400405505 1.1093865506749672 1.3207662988219946 1.366900940090187 1.42901668334319 1.0787025108372246 1.262647452730492 1.2162659118530397 1.1506519037442877 1.519439285915822 1.0 10.67666113617299 -6.254186832053348 24.954586427856622 1.215634322793077 1.311848462130672 0.09792563058961135 0.14893247537312468 1482.2280182609954 5100046.264754021 0.043253720409462994 0.05475057590821925 5.569461010125011e-07 6.254186832053348 0.09621413933759504 GADTAPTLAPEALPS(ph)QGEVER ddPTM_A459_Selumetinib_30min_R1 1 GADTAPTLAPEALPSQGEVER 21 0 Q8IZL8;C9JFV4 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 GADTAPTLAPEALPS(1)QGEVER 212.74 4.6503e-18 4808300.0 1427.6 2040.8 1101.2 997.62 1427.8 1530.3 1682.6 1845.5 1041.4 1630.6 True False 1460.8603023739595 1801.862187257819 951.6630884586185 823.4043946467169 1298.6557420985641 1514.9065714012288 1555.680127330969 1796.5513449711557 1767.1797391533748 1839.9033933890262 0.7939875037042652 0.9793243459043048 0.5172353569638753 0.44752588511184815 0.7058282227016788 0.8233620182692492 0.845522723052035 0.9764378670240844 0.9604741996253959 1.0 10.845414302282684 -7.2756493911231885 1.5262102726779552 0.9763697468845252 0.6860464367582207 0.4448782994025524 0.13829113830792975 0.4374114224541599 1.9856694659481666 0.09118924533925875 0.053838816082836985 5.3009121742644e-08 7.2756493911231885 -0.2903233101263044 GADTAPTLAPEALPS(ph)QGEVER ddPTM_A459_Selumetinib_30min_R2 2 GADTAPTLAPEALPSQGEVER 21 0 Q8IZL8;C9JFV4 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 GADTAPTLAPEALPS(1)QGEVER;GADTAPTLAPEALPS(1)QGEVER 216.32 2.7128e-20 7330300.0 33491.0 22971.5 32169.0 33915.0 35465.0 30049.0 28940.0 36669.0 30372.0 32285.0 True False 31629.70429509545 24733.34018498568 30099.281562958953 29295.71849336173 31009.569638877292 34187.97699233685 30285.767343522086 36775.70071912028 36447.24866458437 31352.848163496117 1.0088303343337615 0.7888706013568018 0.9600174569787033 0.9343877896066397 0.9890511215176138 1.0904265160873534 0.9659654263494816 1.1729620392809463 1.1624860514911568 1.0 14.936308886203845 -6.594138217407472 0.9405592512605269 1.102640941261933 0.9001034603840573 0.45809846733777415 0.07921528290804142 0.4607098347235313 0.8878523239143452 0.0429305504644704 0.04713273964887125 2.546019834125888e-07 6.594138217407472 -0.2025374808778756 GAEAFGDS(ph)EEDGEDVFEVEK ddPTM_A459_Selumetinib_30min_R1 2 GAEAFGDSEEDGEDVFEVEK 20 0 Q99549-2;Q99549 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GAEAFGDS(1)EEDGEDVFEVEK;GAEAFGDS(1)EEDGEDVFEVEK 129.07 0.00031744 0.0 1981.7599999999998 1907.0900000000001 2233.5 2499.9 2111.7 1818.83 2166.77 1817.02 1139.48 1922.46 True False 2027.9311521663071 1683.8070162179115 1930.2029677373096 2063.339393934892 1920.697107850915 1800.534221565508 2003.3287944234646 1768.8267270872313 1933.614335673599 2169.2264673461705 0.9348637326222909 0.7762246319435145 0.8898116433636908 0.9511867133260546 0.885429500683114 0.8300351524699401 0.9235221976958151 0.8154181934038507 0.8913842629069435 1.0 11.082964962965812 -8.560959877576186 21.196001827439265 1.0000000014556814 0.8744527391244665 0.33321877397036737 0.052353174272791264 2721.8914537265346 1515006.626300645 0.049482646697747795 0.012776364476052597 2.7481480298413306e-09 8.560959877576186 -0.12554726233121483 GAEEMETVIPVDVMR ddPTM_A459_Selumetinib_30min_R2 2 GAEEMETVIPVDVMR 15 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 ; 160.86 0.0017368 1642900.0 13484.9 11829.4 14015.5 12853.3 14584.0 12050.0 10826.5 10572.7 9094.400000000001 11733.2 False True 12735.463242331753 12736.676942483922 13113.7579889226 11102.658366820764 12751.827537385767 13709.778120991012 11329.953702302762 10603.46480659529 10913.534118767158 11394.432029485293 1.1176917997646818 1.1177983167151562 1.150891764941703 0.9743933122853768 1.119127965693064 1.2031997808679111 0.994341242545861 0.9305830057309374 0.957795359218106 1.0 13.476041392905021 -7.448083070742877 6.891847028813194 0.9588249992307966 1.109352198046192 0.6122849859722461 0.05612647328845308 0.17433091344861698 13.665244315743935 0.024601184340838897 0.01640114161840343 3.563829588812259e-08 7.448083070742877 0.15052719881539545 GAEETSWS(ph)GEER ddPTM_A459_Selumetinib_30min_R1 1 GAEETSWSGEER 12 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 GAEET(0.001)S(0.005)WS(0.994)GEER 104.94 0.0095334 55597000.0 1217.1 1722.4 1821.5 1848.4 1512.3 1332.9 1430.3 1580.5 928.37 1204.3 True False 1245.4560619356585 1520.740607277964 1574.1503047833037 1525.611638765252 1375.5127320182514 1319.4922361763693 1322.4113194588642 1538.5800058124676 1575.3760845379477 1358.8836358753856 0.9165288543145509 1.119110251333854 1.158414350739638 1.1226948345598857 1.012237321654222 0.9710119404936092 0.9731600885803396 1.132238232320255 1.1593163998351477 1.0 10.408206204981381 -11.512347439572562 2.974632890462359 0.9402622563896237 1.0642059953399325 0.0476281145966545 0.0839456849585923 68821718.74167663 40782.0640682317 28159341.571994677 0.02160515174737721 3.073636893159942e-12 11.512347439572562 0.12394373895030886 GAEETSWS(ph)GEER ddPTM_A459_Selumetinib_30min_R2 2 GAEETSWSGEER 12 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 GAEETSWS(0.999)GEER;GAEETSWS(1)GEER 158.25 0.00045232 181527000.0 49866.0 55086.0 56971.0 53027.0 64357.0 44347.0 41614.0 44572.0 41008.0 42857.0 True False 47094.64734941419 59310.91907059273 53305.54788533475 45804.63112332276 56271.89830112015 50455.39670801564 43549.13345657664 44701.69714070818 49210.74585925444 41619.60705414132 1.1315495431792666 1.4250715772841747 1.2807797011632438 1.1005541466005988 1.3520526089522718 1.2122987283945326 1.0463609951897257 1.0740538007136273 1.182393331951407 1.0 15.344975723678012 -7.125136336524084 4.606158051607195 1.0828665151208599 1.261616039903482 0.4345564704397705 0.09833383629747924 0.22714591461489486 7.511513631608532 0.038072187635810814 0.029289449497175338 7.496588346540565e-08 7.125136336524084 0.17874952478262207 GAES(ph)ENEEESPR ddPTM_A459_Selumetinib_30min_R2 2 GAESENEEESPR 12 0 Q9UEG4 Q9UEG4 ZNF629 Zinc finger protein 629 1 GAES(1)ENEEESPR;GAES(1)ENEEESPR 147.39 0.00063095 10591200.0 54891.0 37369.0 39804.0 50923.0 55571.0 55415.0 86805.0 85402.0 82726.0 38825.0 True False 51840.377966083004 40235.08213972658 37243.053975318384 43987.19955292522 48589.67416895668 63047.91324271509 90841.60450084427 85650.50568093783 99273.5115575665 37704.02137053546 1.3749296781004552 1.0671297298587112 0.9877740522506357 1.1666447756498428 1.288713309687651 1.6721800739266794 2.409334633250399 2.27165439036885 2.632968790834224 1.0 15.20243078373116 -6.928969818068435 2.525882343919932 2.1818593889150253 1.1469278427798137 0.4980538546804475 0.4209862383986889 0.2051900427268568 2.655508070754974 0.16009685371528287 0.13376190270816304 1.1776878158177966e-07 6.928969818068435 -1.0349315461352115 GAES(ph)PFEEK ddPTM_A459_Selumetinib_30min_R1 9 GAESPFEEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK 156.58 0.00082205 7778461500.0 76689.6 93288.09999999999 95611.0 100183.1 75944.40000000001 71890.59999999999 77484.7 72038.29999999999 45086.03 63473.4 True False 78476.31846801484 82365.88588353887 82627.5513536297 82688.00225469768 69075.24242907291 71167.44583544215 71639.96669571014 70127.61027062342 76507.69995665558 71620.82917327312 1.0957192114902239 1.15002698006009 1.1536804628961763 1.1545245036838323 0.9644574522023246 0.9936696720344568 1.0002672060999285 0.9791510525654886 1.0682325356993507 1.0 16.128091600766453 -6.256237401316706 24.99990985473404 0.9995210830652852 1.1403972149171535 0.8365187184835795 0.02977510734413135 161.03157539980606 773893.122551653 0.008816180571708042 0.01103664783114609 5.543226170194293e-07 6.256237401316706 0.1408761318518683 GAES(ph)PFEEK ddPTM_A459_Selumetinib_30min_R2 12 GAESPFEEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK;GAES(1)PFEEK 184.36 0.00086171 6558694000.0 2319344.0 2291724.0 2241307.0 2225880.0 2202660.0 1658028.0 1967549.0 1800964.9 1461997.0 1993127.0 True False 2190444.1455496643 2467491.8617459065 2097103.7477705516 1922711.3041428234 1925942.1587697566 1886406.3069203738 2059043.9271243818 1806205.409693209 1754437.2516092565 1935580.2447441418 1.1316731256673949 1.2748073186043891 1.083449654678492 0.9933513784115835 0.9950205701879029 0.9745947304652988 1.0637863931064042 0.9331596634124386 0.9064141134800484 1.0 20.88433468904153 -5.544613652650104 3.1408913062973403 0.9818286303524468 1.2028874684044726 0.747983131194903 0.05147477400026046 0.11518311491749575 2.328011274441818 0.01436896892363329 0.029745358360120374 2.8535556551104517e-06 5.544613652650104 0.22105883805202575 GAESPFEEK ddPTM_A459_Selumetinib_30min_R2 1 GAESPFEEK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 144.12 0.0057947 0.0 17158.0 15749.0 14166.0 18732.0 18628.0 11498.0 15704.0 15082.0 11614.0 14821.0 False True 16204.42704891607 16956.89765898349 13254.574982774611 16180.669285497617 16287.784103567077 13081.745131548108 16434.26711688566 15125.886123040482 13937.124522273234 14393.07922041741 1.1258485276680168 1.1781285574339893 0.9208991891027901 1.1241978896735598 1.1316399954543375 0.908891345014686 1.1418173182547837 1.0509138379217382 0.9683212541832342 1.0 13.813087651321652 -1.5228787452803598 0.4610894059902875 1.0302985847885762 3.9667756085575987 0.15161399764477268 0.08653487438080472 184.59335227751234 2.1675264614200787 0.05193537790027156 513.8577080868505 0.029999999999998462 1.5228787452803598 2.9364770237690223 GAGATS(ph)GSPPAGRN ddPTM_A459_Selumetinib_30min_R2 1 GAGATSGSPPAGRN 14 1 B4DEE8;P16455 B4DEE8 MGMT Methylated-DNA--protein-cysteine methyltransferase 1 GAGAT(0.392)S(0.555)GS(0.054)PPAGRN 101.45 0.014868 20332000.0 5150.0 5102.5 4023.0 4767.8 5244.5 4871.5 3812.2 1033.1 2099.8 5194.1 True False 4863.783617083447 5493.845342876585 3764.164559911214 4118.417415086248 4585.639023575126 5542.5049059259545 3989.4748537309943 1036.1061499610882 2519.8186733140483 5044.132837107484 0.9642457433521008 1.089155563561047 0.746246120288486 0.8164767955333865 0.9091035410171161 1.0988023283511021 0.7909139157442818 0.2054081808351492 0.49955438420987686 1.0 12.300390554165002 -7.535465263519487 24.087842970911115 0.5111207025471085 0.9301162049653128 0.37671043952024263 0.20848834494806168 132.91563667223528 254366.32378812073 0.09460055375219652 0.05467012230512175 2.9143032222101616e-08 7.535465263519487 0.41899550241820427 GAGATSGS(ph)PPAGR ddPTM_A459_Selumetinib_30min_R1 1 GAGATSGSPPAGR 13 0 B4DEE8;P16455 B4DEE8 MGMT Methylated-DNA--protein-cysteine methyltransferase 1 GAGAT(0.003)S(0.016)GS(0.982)PPAGR 144.28 0.00067761 5024500.0 1104.7 1515.3 946.7 988.71 1163.3 1002.1 1212.7 1058.9 603.55 1248.2 True False 1130.4373606279873 1337.8879715561418 818.1433398508669 816.0503588853024 1058.0797203972954 992.0197838340009 1121.225062649629 1030.8145322080497 1024.180268452102 1408.4186284975967 0.8026288049270262 0.9499220931089983 0.5808950004613369 0.5794089501328226 0.7512537103588167 0.7043500872267068 0.7960879244019047 0.7318949858733771 0.7271845513323169 1.0 10.459860498957712 -10.681996016785527 9.197244435761139 1.0000000020498547 0.7342556200668354 0.376773868674684 0.10185576727513368 1.0993910681358292e-08 9.36371787504641e-10 0.10508076653610467 0.025485829011362968 2.0797157615250305e-11 10.681996016785527 -0.2657443819830193 GAGATSGS(ph)PPAGR ddPTM_A459_Selumetinib_30min_R2 1 GAGATSGSPPAGR 13 0 B4DEE8;P16455 B4DEE8 MGMT Methylated-DNA--protein-cysteine methyltransferase 1 GAGAT(0.021)S(0.112)GS(0.866)PPAGR 89.189 0.029951 0.0 7779.1 6719.9 8650.1 6419.4 7600.5 6373.6 7024.2 6635.4 5971.7 6013.7 True False 7346.768764204622 7235.294722115895 8093.56198351678 5545.066645917329 6645.657240667891 7251.505546219773 7350.839218188247 6654.707915450392 7166.206863239112 5840.068855530944 1.257993517875518 1.2389057220213382 1.3858675614503455 0.9494865185820149 1.1379415902560805 1.241681515339002 1.258690505202948 1.1394913450631543 1.2270757486792685 1.0 12.51176966351865 -14.320629568574548 0.23884731424234998 5.278710688993969e-20 1.221765856288869 0.24473706757874358 0.10748105062099372 241.79297105956246 2.634136449364703 117.58725741610506 0.1783731129955275 4.779367559497864e-15 14.320629568574548 1.221765856288869 GAGDGS(ph)DEEVDGK ddPTM_A459_Selumetinib_30min_R1 4 GAGDGSDEEVDGK 13 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 GAGDGS(1)DEEVDGK;GAGDGS(1)DEEVDGK;GAGDGS(1)DEEVDGK;GAGDGS(1)DEEVDGK 199.38 0.00013358 148387100.0 10971.2 14066.7 8070.700000000001 7728.7 8872.4 9080.400000000001 10558.900000000001 10605.900000000001 6069.1 11052.3 True False 11226.807613760997 12419.76422456859 6974.74326918178 6379.027630667065 8069.892986549443 8989.059420343538 9762.433671980842 10324.597079181565 10298.819430474121 12470.970363518667 0.9002352893566952 0.9958939731666855 0.5592783132245265 0.5115101266961259 0.6470942317493034 0.7207987156026956 0.7828126751498737 0.8278904350044894 0.8258234227387197 1.0 13.606286104875041 -8.446834507551108 0.9304516773996577 0.992319290458272 0.7188446037551441 0.2632526393746054 0.13726982434374657 0.8846519366699179 1.6945514491053892 0.14788146327364424 0.05128089773640403 3.5740900664148025e-09 8.446834507551108 -0.2734746867031279 GAGDGS(ph)DEEVDGK ddPTM_A459_Selumetinib_30min_R2 2 GAGDGSDEEVDGK 13 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 GAGDGS(1)DEEVDGK;GAGDGS(1)DEEVDGK 204.18 4.331100000000001e-05 352000000.0 461610.0 326370.0 426240.0 379870.0 443960.0 406690.0 544740.0 481990.0 448350.0 340130.0 True False 435955.5641712406 351401.5295550474 398816.18245502264 328131.0506876998 388185.77574724285 462707.85593575344 570071.4893818318 483392.51110225986 538032.5279456854 330309.56313612947 1.3198393653276443 1.0638551491475448 1.2074012591959373 0.9934046340416374 1.1752180955997966 1.4008309403535466 1.7258703743521044 1.4634529697314298 1.6288736021970631 1.0 18.333459213631386 -6.819816108599728 3.7753728970280407 1.5004934141103292 1.1385642760933088 0.3476121562926269 0.19630159522145693 0.20957469897224515 6.041893752362809 0.06690827511947546 0.0602164320910468 1.5142022647131908e-07 6.819816108599728 -0.3619291380170204 GAGDGS(ph)DEEVDGKADGAEAK ddPTM_A459_Selumetinib_30min_R2 1 GAGDGSDEEVDGKADGAEAK 20 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 GAGDGS(1)DEEVDGKADGAEAK 77.51 0.0028914 7255500.0 41060.0 32591.0 33776.0 32633.0 33816.0 30606.0 45528.0 44429.0 31493.0 33104.0 True False 38778.04957620315 35090.62490341807 31602.888932528258 28188.329104935074 29567.73176112431 34821.69868639425 47645.14221202054 44558.28103438311 37792.47998794135 32148.20150547854 1.2062276507006087 1.0915268431871095 0.9830375402848787 0.8768244500436939 0.919732065138559 1.0831616406429487 1.4820468947197898 1.3860271787455887 1.175570583054263 1.0 14.972450409429142 -7.054654426066365 8.336813965612533 1.2923594687700315 1.0092470155970494 0.3783008373549267 0.1468642616547474 0.3365029145196794 48.056342970560536 0.05721100792692953 0.0445107585278502 8.817502143882091e-08 7.054654426066365 -0.28311245317298206 GAGDGS(ph)DEEVDGKADGAEAKPAE ddPTM_A459_Selumetinib_30min_R1 5 GAGDGSDEEVDGKADGAEAKPAE 23 2 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE 77.40100000000002 0.00087695 680789400.0 13008.55 15649.8 18737.0 19214.8 14484.489999999998 14260.93 13633.39 13738.79 8342.13 12593.63 True False 13311.623904767986 13817.514140605359 16192.618314973797 15859.295886467531 13174.370436944415 14117.47799208843 12605.012415994734 13374.392659320642 14155.985324931384 14210.14508284425 0.9367690355842293 0.9723696739231107 1.139511118329324 1.1160544662991712 0.9271101990963967 0.9934788075550547 0.8870431893909813 0.9411862145916721 0.9961886555276446 1.0 13.794633663843824 -6.281586672626239 24.853047494131538 0.9528364674093224 1.0432852704031952 0.2848668809033027 0.06466176716728377 1005.2192513822159 1240002.8069560647 0.021618810347874703 0.02454523314265823 5.228936013186897e-07 6.281586672626239 0.09044880299387281 GAGDGS(ph)DEEVDGKADGAEAKPAE ddPTM_A459_Selumetinib_30min_R2 4 GAGDGSDEEVDGKADGAEAKPAE 23 2 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE;GAGDGS(1)DEEVDGKADGAEAKPAE 80.171 0.00072175 376898000.0 176261.0 171769.0 163178.0 166541.0 153539.0 121458.9 139980.0 130174.1 94732.5 155990.0 True False 166465.11924868822 184943.12997561358 152679.30513477293 143857.8285007507 134250.0581639244 138188.76098088262 146489.34736510777 130552.88507951774 113681.64704720577 151486.16338930622 1.0988800265598342 1.220858234427166 1.007876242415622 0.9496433554201821 0.8862199369252851 0.9122203499586267 0.9670147034395671 0.8618139251702363 0.7504424463840559 1.0 17.208826499677883 -5.563768722429779 2.1596292272961173 0.8966011462604251 1.1615254653582918 0.6733478545729115 0.07054750180026152 0.17795326330581976 1.648625135004236 0.02055803723964717 0.048581529418479714 2.73043144953059e-06 5.563768722429779 0.26492431909786673 GAGES(ph)GEEDPFPSRDPR ddPTM_A459_Selumetinib_30min_R2 1 GAGESGEEDPFPSRDPR 17 1 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 GAGES(0.998)GEEDPFPS(0.002)RDPR 54.292 0.045511 3777200.0 25941.0 19517.0 26631.0 28764.0 27669.0 18617.0 23185.0 22767.0 18696.0 24458.0 True False 24499.303070050813 21013.8911429539 24917.590453640445 24846.29357933235 24192.972856001572 21181.32276170038 24263.148440205943 22833.24820072024 22435.722409886377 23751.833990484374 1.0314699521673103 0.8847270973421518 1.0490806926161198 1.0460789507575055 1.0185728338154405 0.8917763053659852 1.0215273671046377 0.961325690044308 0.9445890544231125 1.0 14.535751294543497 GAGGALLT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 GAGGALLTPK 10 0 Q8N1G0;Q8N1G0-2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 GAGGALLT(1)PK;GAGGALLT(1)PK 110.84 0.02155 3816400.0 62019.0 59589.0 61705.0 65614.0 64265.0 53391.0 53404.0 63150.0 44634.0 56873.0 True False 58572.23226172782 64159.284691165616 57734.967479324274 56677.260009536694 56191.45616361058 60745.12561475774 55887.391818018456 63333.756044954695 53562.04717815946 55230.9287161999 1.0604969647115108 1.1616550035007274 1.0453376182752818 1.026186981225115 1.0173911152634474 1.0998389313149546 1.0118857878561438 1.1467081491674815 0.9697835691553212 1.0 15.753188766291958 -1.5228787453119164 0.07245673131862942 0.94729493797965 1.3240079106162803 0.1631892050306929 0.05511356863025887 470.8748045819972 2.5214663138755666 2.2107941816771532 17.99501319824102 0.029999999997818615 1.5228787453119164 0.3767129726366303 GAGGPAS(ph)AQGSVK ddPTM_A459_Selumetinib_30min_R2 2 GAGGPASAQGSVK 13 0 Q9UHV7 Q9UHV7 MED13 Mediator of RNA polymerase II transcription subunit 13 1 GAGGPAS(0.997)AQGS(0.003)VK;GAGGPAS(1)AQGSVK 152.11 0.00044754 8314000.0 36082.0 28683.0 37769.0 38769.0 34300.0 24468.0 30998.0 35656.0 29476.0 29166.0 True False 34076.706887690256 30882.89386961861 35338.98365977794 33488.59531974467 29990.927354109415 27838.244901610622 32439.468421371737 35759.75305683143 35372.02362825261 28323.901797631326 1.2031077897092564 1.09034744189804 1.2476735695621313 1.1823439990370699 1.058855787892101 0.9828534606746405 1.145303660955518 1.2625291992723247 1.2488400744000145 1.0 14.78973239907887 -11.469567183882925 2.5576670932150045 0.8875228582942791 1.153984472509468 0.22878686738662735 0.08673803807442015 11342564.12630179 5591335.990058326 7587390.466554387 0.02366064421910367 3.39182015175736e-12 11.469567183882925 0.26646161421518877 GAGGS(ph)PVGVEEGLVNVGTGQK ddPTM_A459_Selumetinib_30min_R1 4 GAGGSPVGVEEGLVNVGTGQK 21 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK 328.29 9.271899999999995e-156 96710000.0 12185.0 15159.300000000001 13423.8 14366.5 13093.6 11816.7 13938.9 12242.6 6649.200000000001 11440.699999999999 True False 12468.886792117331 13384.442108632622 11600.92169165529 11857.660467604965 11909.286191862831 11697.834726705152 12887.477550727222 11917.886478430708 11283.20676164645 12909.225286855039 0.9658896266078735 1.0368121875029541 0.8986535933700109 0.9185416013832495 0.9225407355768741 0.9061608630083017 0.9983153337520602 0.9232069480239242 0.8740421296338906 1.0 13.656114803250414 -5.2641990605282745 24.999787367570804 0.9283267532064835 1.0013509076755522 0.3217545099607978 0.04126081235322171 247.9238494036987 2245944.9597242903 0.01042947239200939 0.02331339753919278 5.442531351677099e-06 5.2641990605282745 0.07302415446906874 GAGGS(ph)PVGVEEGLVNVGTGQK ddPTM_A459_Selumetinib_30min_R2 5 GAGGSPVGVEEGLVNVGTGQK 21 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK;GAGGS(1)PVGVEEGLVNVGTGQK 213.45 3.7396e-42 85985700.0 352391.1 317866.7 322602.1 377218.0 390871.5 302915.69999999995 295105.1 352619.2 304833.89999999997 367781.5 True False 332806.61339534237 342246.05378746707 301846.2321086089 325840.25766265433 341766.7277344541 344639.58808005595 308828.071889662 353645.2634927487 365809.1977708105 357162.692483904 0.9318067659329808 0.9582357311938196 0.8451225126829616 0.9123020531528184 0.9568936927807942 0.9649372550174388 0.86467057839077 0.9901517457865121 1.0242088702679835 1.0 18.44622186570382 -7.928633022085801 7.517414299253889 1.010529187510416 0.9208735922180228 0.5279069535009264 0.03745942219870093 0.18065542329321435 16.037941582665788 0.021272514536487524 0.010135772754034864 1.1786014686020375e-08 7.928633022085801 -0.08965559529239331 GAGKPATGPTNSSS(ph)AK ddPTM_A459_Selumetinib_30min_R1 1 GAGKPATGPTNSSSAK 16 1 M0R1H1;M0R3B3;Q9BT25-3;Q9BT25 M0R1H1 HAUS8 HAUS augmin-like complex subunit 8 1 GAGKPATGPT(0.001)NS(0.007)S(0.242)S(0.75)AK 64.26 0.032348 11906000.0 2036.7 1943.4 2381.6 2713.9 1940.0 1540.5 1662.5 1299.3 1126.8 875.65 True False 2084.1511472716766 1715.865824537851 2058.1918011923785 2239.968311212412 1764.5273425348194 1525.0039686620873 1537.096286513571 1264.838343278798 1912.0973017841584 988.0482070532937 2.1093618027882934 1.736621565920518 2.0830884429522203 2.267063788206026 1.7858717114595641 1.543450975140357 1.5556895660969126 1.2801382910768995 1.9352267309777356 1.0 9.948437622657616 -6.628640871559373 2.957900906963205 1.4802076693271624 2.0302225594104293 0.5417372021944147 0.25354207961618 0.2125546385130022 3.743740971599617 0.08647252439564046 0.08653026602413037 2.3515765916991166e-07 6.628640871559373 0.5500148900832669 GAGNCPECGT(ph)PLRK ddPTM_A459_Selumetinib_30min_R2 1 GAGNCPECGTPLRK 14 1 P51948;P51948-2 P51948 MNAT1 CDK-activating kinase assembly factor MAT1 1 GAGNCPECGT(1)PLRK 88.95100000000002 0.025132 7218100.0 11316.0 10776.0 10275.0 10815.0 13134.0 10375.0 7306.9 9532.7 7713.4 9854.1 True False 10687.102021537132 11602.484549698778 9613.917686574123 9341.978343084396 11483.989500550239 11804.062075127122 7646.68532834767 9560.43857877656 9256.295530403166 9569.58652897343 1.1167778241181316 1.212433213762207 1.0046325050164364 0.9762154628938341 1.2000507509682525 1.2334976061283802 0.7990612034486679 0.9990440600365362 0.9672618040892648 1.0 13.224240876511727 -7.2559323013959 24.99995032000052 0.9412621053942023 1.1192797253654827 0.4714801746987022 0.09463132963321946 446.1515519808496 2025355.8289555844 0.038928774548464024 0.029286908011775015 5.5471217574930946e-08 7.2559323013959 0.1780176199712804 GAGPQLLEELDNAPGSDAAELELAPART(ph)PPDSVKDASAAEPAAAER ddPTM_A459_Selumetinib_30min_R1 1 GAGPQLLEELDNAPGSDAAELELAPARTPPDSVKDASAAEPAAAER 46 2 Q9UHR6 Q9UHR6 ZNHIT2 Zinc finger HIT domain-containing protein 2 1 GAGPQLLEELDNAPGS(0.156)DAAELELAPART(0.664)PPDS(0.136)VKDAS(0.044)AAEPAAAER 68.154 2.1244e-09 5080800.0 594.86 322.28 1234.9 1113.5 888.64 732.71 546.29 482.59 429.71 353.63 True False 608.7190806039323 284.5473077760929 1067.2073628201488 919.0481279837203 808.2626689021346 725.3396026474508 505.0829054793975 469.7901455267566 729.1864852233499 399.02185514789727 1.5255281703261865 0.7131120867317545 2.674558671540908 2.3032526066600427 2.0256100222945244 1.817794171646573 1.2658026094640573 1.1773544217336895 1.8274349532886545 1.0 8.640323957400259 -7.23487807729264 7.414266366804417 1.3322320394692932 1.8599467501287603 0.1966149073071488 0.519636882803894 0.4026872217557007 91.77539630658366 0.21722362807382437 0.16454798596557824 5.822666588606279e-08 7.23487807729264 0.5277147106594671 GAGQQQS(ph)QEMMEVDR ddPTM_A459_Selumetinib_30min_R1 1 GAGQQQSQEMMEVDR 15 0 B5MBZ8;Q15435-3;Q15435;C9JRC4 B5MBZ8 PPP1R7 Protein phosphatase 1 regulatory subunit 7 1 GAGQQQS(1)QEMMEVDR 145.94 0.00036417 0.0 914.66 1183.2 1187.8 1365.4 812.58 976.09 901.66 899.91 861.61 894.04 True False 935.9697983814561 1044.6703939452439 1026.5032841183686 1126.9585217323504 739.0822824726507 966.2714208188098 833.6470602693697 876.0414634803536 1462.0892404954284 1008.7987426870635 0.9278062697504774 1.0355587787140095 1.017550122420005 1.1171291894462054 0.7326360067658404 0.9578436014353301 0.8263759905656156 0.8684006297895515 1.4493368980625096 1.0 9.978422667343843 -8.240238367733387 24.814979615497233 1.224668534249727 0.9378998392501001 0.39051485324512825 0.14451887756279772 630.0151156842799 737411.5436282704 0.09552284144104761 0.03602452872559802 5.7512418688792194e-09 8.240238367733387 -0.28676869499962687 GAGQQQS(ph)QEMMEVDR ddPTM_A459_Selumetinib_30min_R2 2 GAGQQQSQEMMEVDR 15 0 B5MBZ8;Q15435-3;Q15435;C9JRC4 B5MBZ8 PPP1R7 Protein phosphatase 1 regulatory subunit 7 1 GAGQQQS(1)QEMMEVDR;GAGQQQS(1)QEMMEVDR 174.4 2.5813e-05 21077000.0 37167.0 33687.0 35255.0 38243.0 42361.0 32260.0 35606.0 31896.0 24144.6 36518.0 True False 35101.406931289384 36270.68457922263 32986.73168274171 33034.23742714528 37039.232467855094 36703.522172877165 37261.74955195049 31988.812079332933 28974.194656490297 35463.630454841266 0.9897860563369808 1.0227572336512205 0.9301566494932436 0.9314962118503481 1.0444286722144867 1.034962345990345 1.050703187294908 0.9020174096407557 0.8170115209548414 1.0 15.114052613786468 -7.836298928001341 8.176434725425581 0.8933696412150443 0.9990088341369868 0.3535318621165703 0.05763870303676126 0.2763968445503222 26.579618422397168 0.03225743869980379 0.015457920628649252 1.4578104934648027e-08 7.836298928001341 0.10563919292194257 GAGSIAGASAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 GAGSIAGASASPK 13 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 GAGS(0.012)IAGAS(0.035)AS(0.954)PK 109.6 0.0058794 2998500.0 3188.8 4445.6 4145.8 4062.8 3311.4 3594.6 3757.6 4347.3 2764.8 4184.6 True False 3263.092835675318 3925.10708529663 3582.82313124931 3353.308248201401 3011.8844546751557 3558.4415876356634 3474.1612067388837 4231.995481979466 4691.663666997552 4721.734171455733 0.6910793189929392 0.8312850623876822 0.7587939094302525 0.7101857339773874 0.6378767514873835 0.7536302253412497 0.7357807704934357 0.8962799107927588 0.9936314702678593 1.0 12.205101106339205 -7.927303137889754 2.3705876353341 0.9972809401550101 0.7305341295226822 0.8413031608048075 0.04745776814030609 0.123209534302466 1.3268788698233316 0.03867170168535028 0.014266489805594836 1.1822160799142131e-08 7.927303137889754 -0.26674681063232797 GAGSIAGASAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GAGSIAGASASPK 13 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 GAGSIAGAS(0.004)AS(0.996)PK 139.48 0.00093275 4998500.0 49485.0 43293.0 43518.0 41048.0 42946.0 34105.0 40942.0 49475.0 30504.0 46128.0 True False 46734.821804150335 46613.43389106435 40718.09925881584 35457.19158825041 37550.73953788872 38802.65417563475 42845.88412503393 49618.96405897283 36605.65235297251 44796.16478506266 1.0432772990364148 1.0405675154272953 0.9089639582804943 0.7915229296610155 0.8382579115435808 0.8662048271724714 0.9564632224792813 1.1076609860922366 0.8171604093477822 1.0 15.451087601064039 -10.142564900677 15.342575564025914 0.9999999999905276 0.9299964272875909 0.04137195424258022 0.10107337577111287 0.0 0.0 0.10493661247744322 0.025450866896412155 7.20170121455046e-11 10.142564900677 -0.07000357270293667 GAGTDDHTLIR ddPTM_A459_Selumetinib_30min_R2 1 GAGTDDHTLIR 11 0 P08758;D6RBE9;D6RBL5 P08758 ANXA5 Annexin A5;Annexin 0 204.56 2.4832e-05 8606000.0 80458.0 72364.0 89607.0 84418.0 103960.0 66012.0 68541.0 65496.0 57175.0 83197.0 False True 75986.46645889315 77914.08611306618 83841.78317672481 72920.12277082745 90899.61538580798 75104.5538027268 71728.29231141493 65686.58251655352 68611.59760297676 80794.88643823395 0.9404860853042136 0.9643442740974691 1.0377115046856356 0.9025338853167818 1.1250664416156941 0.929570633905683 0.8877825747827464 0.8130042062348782 0.8492071791626186 1.0 16.301976366293182 -6.996551186335293 24.999512988378328 0.8771670772226795 0.9934826677138597 0.328135598418261 0.07162338301334602 109.44520114051488 793329.493667473 0.024605282243044733 0.021596025604669306 1.0079728017889032e-07 6.996551186335293 0.11631559049118023 GAGTDEGCLIEILASR ddPTM_A459_Selumetinib_30min_R1 2 GAGTDEGCLIEILASR 16 0 P09525;P09525-2 P09525 ANXA4 Annexin A4 0 ; 168.82 8.0696e-05 2091700.0 649.3299999999999 752.1400000000001 911.28 757.02 831.0 1072.74 870.24 792.89 240.78 618.15 False True 664.4581256237623 664.0790991396004 787.5331813027329 624.8206680253578 755.8361967249664 1061.9492095699893 804.5970961657564 771.8599815303058 408.58607412459156 697.4955737908906 0.9526341823395814 0.9520907717454442 1.1290869948069888 0.8958059255192912 1.0836430009397684 1.5225174889616748 1.153551544123454 1.1066163149039705 0.5857902035190345 1.0 9.446040251605162 -8.232027734207108 23.280818806073732 0.7928951786503163 1.1041512275062113 0.29806302367160586 0.1880934991485835 331.6262522720889 262500.164072536 0.1333383257715022 0.05037050009075938 5.861007347080391e-09 8.232027734207108 0.311256048855895 GAGTDEGCLIEILASR ddPTM_A459_Selumetinib_30min_R2 2 GAGTDEGCLIEILASR 16 0 P09525;P09525-2 P09525 ANXA4 Annexin A4 0 ; 203.74 4.4904e-06 8674300.0 15596.400000000001 16889.3 18446.6 19396.4 19528.3 12981.0 12990.0 15196.400000000001 12102.8 16112.2 False True 14729.614525335977 18184.655002341107 17259.7658391395 16754.576859343706 17074.98036878294 14769.014920214466 13594.06073919669 15240.619008100555 14523.698180486355 15646.998921476914 0.9413699457164438 1.162181648608733 1.1030719645189544 1.070785327168812 1.0912623215782289 0.9438880257058536 0.8687966815500714 0.9740282519724236 0.9282098281831714 1.0 13.933598355794473 -6.771578952630837 11.20558681437553 0.9366668592774728 1.0801304274101453 0.5345579525924256 0.06071338398008461 0.21941633990407644 231.99623780406276 0.020327881189077787 0.01853079763460935 1.6920806044248559e-07 6.771578952630837 0.14346356813267247 GAGTGGLGLAVEGPSEAK ddPTM_A459_Selumetinib_30min_R2 2 GAGTGGLGLAVEGPSEAK 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 246.5 1.322e-31 7593200.0 22232.2 22551.3 28613.0 29399.0 29733.0 19416.2 25076.4 24189.4 17445.199999999997 23217.0 False True 20996.623326548062 24280.912196141642 26772.070731478874 25394.805483896267 25997.674723607455 22090.60530728511 26242.502287943935 24259.787149229254 20934.72745961435 22546.664884989597 0.9312518473863746 1.0769181304640145 1.1874071339616323 1.1263220353624368 1.1530607677996474 0.979772636883067 1.163919471984295 1.0759811827149728 0.9285066135680053 1.0 14.460626424571897 -8.184656144916877 5.982873085739723 0.9651244464058072 1.0931035262121482 0.2824776280362884 0.07785731966336802 0.2636048879505468 15.829838182892056 0.055141513843582006 0.020088669344906822 6.536478771828542e-09 8.184656144916877 0.12797907980634105 GAILSEEELAAMS(ph)PTAAAVAK ddPTM_A459_Selumetinib_30min_R1 2 GAILSEEELAAMSPTAAAVAK 21 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 GAILSEEELAAMS(0.89)PT(0.11)AAAVAK;GAILS(0.001)EEELAAMS(0.86)PT(0.139)AAAVAK 211.67 6.206000000000001e-18 27398000.0 8582.2 11632.9 9834.4 10843.2 10003.2 8642.2 10241.6 9299.5 5376.200000000001 8659.2 True False 8782.148561945787 10270.91466001151 8498.942496492411 8949.638672072817 9098.4123262084 8555.267314489778 9469.06786644054 9052.84705096681 9123.018737887814 9770.692667750676 0.8988255859210785 1.0511961648237975 0.8698403261156881 0.9159676776665133 0.9311941983641326 0.8756049960232039 0.9691296398764354 0.9265307341870244 0.9337125880542138 1.0 13.254245126580043 -8.617008499594213 14.529204208404758 1.000000000469954 0.9308763666070151 0.1545790588919097 0.048978563204063116 1080.3241529848012 166755.76582987703 0.04584601184400092 0.011837342682834078 2.415413561829499e-09 8.617008499594213 -0.06912363386293896 GAILSEEELAAMS(ph)PTAAAVAK ddPTM_A459_Selumetinib_30min_R2 8 GAILSEEELAAMSPTAAAVAK 21 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 GAILSEEELAAMS(0.984)PT(0.016)AAAVAK;GAILS(0.083)EEELAAMS(0.901)PT(0.015)AAAVAK;GAILSEEELAAMS(0.93)PT(0.07)AAAVAK;GAILSEEELAAMS(0.956)PT(0.044)AAAVAK;GAILSEEELAAMS(0.978)PT(0.022)AAAVAK;GAILSEEELAAMS(0.839)PT(0.161)AAAVAK;GAILSEEELAAMS(0.9)PT(0.099)AAAVAK;GAILSEEELAAMS(0.971)PT(0.029)AAAVAK 231.42 5.0784e-25 48546500.0 161230.9 140779.8 160811.0 188643.0 189339.4 141422.9 158645.0 164611.2 134479.8 167145.6 True False 152270.33203643092 151577.15798159628 150464.59533777798 162949.49797267356 165552.89185628775 160902.62076573455 166022.30684910383 165090.19133914885 161379.5176795591 162319.67223157664 0.9380892035020337 0.9338187780797491 0.9269646326239165 1.0038801565604345 1.0199188402752464 0.9912699955195793 1.0228107571104799 1.017068289194298 0.9942080060962897 1.0 17.30847833144567 -5.776169721196129 8.772117944971356 1.0083515434563042 0.9329895401623968 0.9154840402542718 0.01030742742456997 0.041374026073150535 19.80814810473984 0.002818130703869529 0.004343980414799887 1.6742884404284814e-06 5.776169721196129 -0.07536200329390741 GAILSEEELAAMSPT(ph)AAAVAK ddPTM_A459_Selumetinib_30min_R2 2 GAILSEEELAAMSPTAAAVAK 21 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 GAILSEEELAAMS(0.435)PT(0.565)AAAVAK;GAILSEEELAAMS(0.034)PT(0.966)AAAVAK 148.68 2.439e-05 3490600.0 28369.0 30118.0 30343.0 31026.0 36560.0 21976.9 25404.0 27054.0 26849.4 30635.0 True False 26792.364550104918 32427.953755366365 28390.76441496046 26800.20527716471 31967.00594945308 25004.018488564943 26585.336337071036 27132.722660969182 32220.030234916765 29750.487950710965 0.9005689114912364 1.089997374466304 0.9542957568291578 0.9008324610193242 1.0745035846946216 0.8404574247652771 0.8936100940971528 0.9120093326173756 1.0830084631988963 1.0 14.860625710433824 -3.903615523805504 15.009440598855143 0.9614876956889146 0.9670799655722212 0.0 0.08641961968359692 0.0 0.0 0.019418081191764767 0.0 0.0001248488298293566 3.903615523805504 0.005592269883306633 GAKEEHGGLIRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 GAKEEHGGLIRSPR 14 2 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 1 GAKEEHGGLIRS(1)PR;GAKEEHGGLIRS(1)PR 70.45100000000002 0.022537 163024000.0 7566.7 7275.0 18158.8 19500.8 13849.3 10884.099999999999 8878.099999999999 8363.8 5793.7 5482.4 True False 7742.98938776481 6423.239617944255 15692.934699148529 16095.351355352439 12596.6332602925 10774.615835972108 8208.417769200687 8141.96485454876 9831.485744894286 6186.119443098245 1.2516714976144763 1.0383310049259655 2.5367978816925185 2.6018494313603604 2.0362738508624116 1.7417406720125936 1.326909033151419 1.3161667713404113 1.5892815900706732 1.0 12.594818974264806 -7.146098385091826 3.3860143156096356 1.3315966638926184 1.9188018753980198 0.25186319625407105 0.47568291802783425 0.42496513386989654 9.06040022146641 0.22013679574933917 0.16512757984684717 7.143344823778032e-08 7.146098385091826 0.5872052115054014 GAKEEHGGLIRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 GAKEEHGGLIRSPR 14 2 P26368-2;P26368 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 1 GAKEEHGGLIRS(1)PR;GAKEEHGGLIRS(1)PR;GAKEEHGGLIRS(1)PR 63.462 0.030599 315510000.0 368565.0 596680.0 525010.0 560690.0 518760.0 258329.0 155671.0 174711.0 116554.0 483960.0 True False 348081.632782594 642443.4373714062 491231.42818766774 484323.0547558017 453588.7310267588 293911.4748728208 162910.0099562346 175219.38008503686 139868.05679085857 469986.8173209092 0.7406199917835615 1.36693927083649 1.0452025675695764 1.0305034884097688 0.9651094760750413 0.6253611038458907 0.3466267647354008 0.3728176485541641 0.2975999573523272 1.0 18.842260765583525 -6.803449242838421 2.5039380973569596 0.4519374432408534 1.064879415402574 0.5376268702618341 0.23278999478177037 0.19131790811588575 2.455325166592499 0.08516789561365323 0.07683125685272081 1.5723555471371689e-07 6.803449242838421 0.6129419721617206 GAKLT(ph)PEEEEILNK ddPTM_A459_Selumetinib_30min_R1 2 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 GAKLT(1)PEEEEILNK;GAKLT(1)PEEEEILNK 111.73 0.0053152 14498200.0 9645.8 9928.5 11370.7 11613.0 9048.3 9408.099999999999 9413.1 8994.5 5319.7 9195.8 True False 9870.528372540452 8766.066604365571 9826.621394784252 9585.007553008485 8229.88286260711 9313.46305587133 8703.062288469713 8755.936641746437 9027.142364484544 10376.170504677306 0.9512689067793437 0.8448267692222345 0.9470373863223112 0.9237519322458911 0.7931522384773163 0.8975819211599372 0.8387547491193018 0.8438504974257593 0.8699878592410701 1.0 13.340986471290185 -4.743561000534662 24.67803251209827 0.8787799654037712 0.9512691699917982 0.10187621457956952 0.05754448705383038 2162.7409832808703 2985106.799383599 0.013825062339000108 0.4290972292986899 1.8048412132763467e-05 4.743561000534662 0.07248920458802699 GAKLT(ph)PEEEEILNK ddPTM_A459_Selumetinib_30min_R2 2 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 GAKLT(1)PEEEEILNK;GAKLT(1)PEEEEILNK 120.9 0.0027671 31288000.0 148225.0 139865.0 139749.0 148118.0 126890.0 112406.0 123959.0 120380.0 91999.0 128625.0 True False 139987.24789168805 150592.19576314194 130757.70148720671 127944.0728821981 110948.94378900711 127888.90617992663 129723.33912009877 120730.28587001827 110401.37066683438 124911.26204211504 1.120693567602335 1.2055934212910948 1.046804742418826 1.02427972298495 0.8882221024362047 1.0238380758398522 1.0385239649276883 0.9665284290323869 0.883838405456279 1.0 16.930544031125187 -5.548172746630527 2.2652257172475974 0.9727388642543239 1.1634514029618481 0.6528921145749713 0.05426759006610771 0.18639655241434122 1.8975915631875981 0.015927098703813623 0.0373985827034003 2.8302659944697792e-06 5.548172746630527 0.19071253870752425 GALGS(ph)PVAAAGAAMQESFGCVVANR ddPTM_A459_Selumetinib_30min_R1 1 GALGSPVAAAGAAMQESFGCVVANR 25 0 Q5JVS0-2;Q5JVS0 Q5JVS0-2 HABP4 Intracellular hyaluronan-binding protein 4 1 GALGS(1)PVAAAGAAMQESFGCVVANR 107.7 5.3288e-05 0.0 1320.2 1945.6 1757.7 1705.8 1280.2 1521.8 1355.0 1459.6 955.43 1741.5 True False 1350.958091337981 1717.8082475150993 1519.0139943549887 1407.9140518317295 1164.4061360376681 1506.4920736838458 1252.7912590832418 1420.8866665510143 1621.294928153743 1965.0384886465033 0.6874970129814129 0.8741855477336256 0.7730199704135406 0.7164816668814894 0.5925614906605204 0.7666476165164077 0.6375403160404001 0.7230833771249464 0.8250703166992281 1.0 10.940341855077591 -8.599489168108311 2.5596534141822267 0.9994577311424641 0.7226528053535674 0.5811364488599855 0.0728290574939253 0.2738026636033474 4.187750407094903 0.07383124264302815 0.01994315405455225 2.5148427357921403e-09 8.599489168108311 -0.2768049257888967 GALHT(ph)VSHEDIR ddPTM_A459_Selumetinib_30min_R1 1 GALHTVSHEDIR 12 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2;H0YD72 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 GALHT(0.755)VS(0.245)HEDIR 113.54 0.0080175 4703700.0 2810.8 3690.4 3188.8 3236.9 3165.1 3160.6 3081.5 2720.4 1489.7 2519.1 True False 2876.286171135281 3258.3262523795847 2755.778474824594 2671.636179138308 2878.8172638437923 3128.8072335951942 2849.0599740701177 2648.246154895439 2527.9120966168457 2842.451023111918 1.0119035113527903 1.1463086701885776 0.9695078129464356 0.9399057916619433 1.012793972679276 1.100742706964841 1.0023250887717898 0.9316769694051357 0.8893423584302554 1.0 11.472919775618733 -7.674508378840078 4.3216724265230955 0.9326462654551083 1.0293661264391731 0.297084359818793 0.0612195027130732 0.26900625640870734 9.16113461266398 0.032715248245909635 0.017709735068674844 2.1158828631354555e-08 7.674508378840078 0.09671986098406482 GALHT(ph)VSHEDIR ddPTM_A459_Selumetinib_30min_R2 2 GALHTVSHEDIR 12 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2;H0YD72 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 GALHT(0.951)VS(0.049)HEDIR;GALHT(0.989)VS(0.011)HEDIR 116.98 0.0066138 105926000.0 196039.0 212592.0 212991.0 222867.0 214691.0 211186.0 198937.0 214718.0 203875.0 240533.0 True False 185143.93718629525 228897.1228089796 199287.39094706625 192512.13013298088 187719.59721810816 240274.95454436578 208187.96468618716 215342.79383152162 244655.69674345196 233588.18731021226 0.792608304890086 0.9799173727265463 0.8531569735690722 0.8241518218441366 0.8036348043953557 1.0286263073109656 0.8912606715411818 0.9218907698681689 1.047380432892104 1.0 17.833607792576473 -6.758872328039332 24.99999727163618 0.9675391240422031 0.8565352225847289 0.4846179265180278 0.06498503390437578 70.23471204745177 684003.8812745488 0.022274719215857185 0.021309182693894316 1.7423189973034505e-07 6.758872328039332 -0.11100390145747419 GALHTVS(ph)HEDIR ddPTM_A459_Selumetinib_30min_R1 3 GALHTVSHEDIR 12 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2;H0YD72 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 GALHT(0.286)VS(0.714)HEDIR;GALHT(0.433)VS(0.567)HEDIR;GALHT(0.26)VS(0.74)HEDIR 96.135 0.011508 216659100.0 10737.7 13435.900000000001 12501.6 13734.199999999999 12167.7 11332.6 12709.1 11113.4 6237.400000000001 9683.0 True False 10987.867518072906 11862.818581819545 10803.951386373294 11335.779792863961 11067.13368338192 11218.604333177524 11750.442354844885 10818.636530589234 10584.412238328456 10925.907370407178 1.0056709384003701 1.0857513412524429 0.9888379079284342 1.0375138108498816 1.0129258200886138 1.0267892590379373 1.0754660419940005 0.9901819742579471 0.968744460253831 1.0 13.415465476614278 -7.965309620105965 21.817750674251844 0.9827358825786715 1.0327262516307154 0.36063393353402284 0.028706378804394823 43.63383111377156 27442.136611890524 0.014947477016446952 0.007180365118799288 1.0831544290431363e-08 7.965309620105965 0.049990369052043904 GALHTVS(ph)HEDIR ddPTM_A459_Selumetinib_30min_R2 3 GALHTVSHEDIR 12 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2;H0YD72 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 GALHT(0.079)VS(0.921)HEDIR;GALHT(0.131)VS(0.869)HEDIR;GALHT(0.347)VS(0.653)HEDIR 115.06 0.0035375 105771900.0 260556.0 264312.0 276008.0 250192.0 275943.0 282841.0 291813.0 259133.0 253798.0 296186.0 True False 246075.34060830958 284583.8805029681 258249.9457747888 216115.417994727 241276.57337828068 321799.78037503915 305382.88271648996 259887.0341282228 304564.69170861854 287634.340596353 0.8555144705535541 0.9893946595978061 0.8978411452518449 0.7513547149712874 0.8388309020336076 1.1187808093701568 1.061705226445976 0.9035327061066434 1.058860673858218 1.0 18.133876403518883 -6.746212962566688 24.999954244008347 1.024617270099825 0.8687443180470552 0.5349715838359519 0.075455754635656 216.38343866916014 355275.0543498362 0.026906928066042796 0.026809385075474795 1.793853769041167e-07 6.746212962566688 -0.15587295205276985 GALPPS(ph)PALPR ddPTM_A459_Selumetinib_30min_R1 2 GALPPSPALPR 11 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 GALPPS(1)PALPR;GALPPS(1)PALPR 103.46 0.012058 4377700.0 3969.2 4840.8 3854.7 4161.7 4491.299999999999 3350.1 4570.8 3866.2 2290.51 3667.2 True False 4061.674637281257 4274.036885573133 3331.252912351469 3434.9372197843304 4085.0627080034155 3316.401035647427 4226.020876027807 3763.6558168125043 3886.8281777685784 4137.9208415529465 0.9815737885785475 1.0328947916676683 0.805054770236074 0.8301118729219603 0.9872259195925813 0.8014655578579879 1.0212908941104337 0.9095523962222579 0.9393191234440981 1.0 12.014690331360411 GALPPS(ph)PALPRPSR ddPTM_A459_Selumetinib_30min_R1 3 GALPPSPALPRPSR 14 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 GALPPS(1)PALPRPSR;GALPPS(0.999)PALPRPS(0.001)R;GALPPS(0.992)PALPRPS(0.008)R 85.473 0.013504 79153200.0 6392.799999999999 7131.599999999999 8540.8 8311.8 7424.7 6781.6 6843.900000000001 6401.900000000001 4658.0 5688.4 True False 6541.73980177658 6296.628956609107 7381.006271256236 6860.300161809686 6753.137195937254 6713.383261200142 6327.6591129445005 6232.100815698093 7904.285793140407 6418.561549708165 1.0191909435026008 0.9810031278574244 1.1499471048294037 1.0688220575093816 1.0521262659301445 1.04593267653644 0.985837568735662 0.9709497630324119 1.231473085040338 1.0 12.648034298890565 -10.572215277146697 4.131504014117649 0.9999957832275946 1.0520725393663766 0.04344112667506761 0.07693001387852631 53377630.466416426 0.10971856636674804 3123.251596425242 0.01824689376443479 2.677840606390661e-11 10.572215277146697 0.05207675613878193 GALPPS(ph)PALPRPSR ddPTM_A459_Selumetinib_30min_R2 3 GALPPSPALPRPSR 14 1 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 GALPPS(1)PALPRPSR;GALPPS(1)PALPRPSR;GALPPS(1)PALPRPSR 133.87 0.00038014 90710000.0 130982.0 138474.0 129225.0 141532.0 157338.0 111813.0 117757.0 111066.0 100829.0 137679.0 True False 123702.54480248998 149094.51053591198 120910.80418954165 122255.0974436818 137571.7938204336 127214.22581264474 123232.93383106879 111389.18367203377 120997.61739764814 133703.8495369982 0.9251980794184936 1.1151100813642236 0.9043180477468864 0.9143723076563453 1.0289291916188628 0.9514627009856013 0.9216857574244194 0.8331037891411678 0.90496734250098 1.0 17.02868147784853 -7.231729000426466 3.1687593881421607 0.8991267805216864 0.9780913872747099 0.13715912212405235 0.06979616043209608 0.41790338958820455 8.57783807031612 0.029964342049434288 0.021104562486137617 5.8650402861912095e-08 7.231729000426466 0.07896460675302353 GALQGSAWQVS(ph)SEDVR ddPTM_A459_Selumetinib_30min_R2 2 GALQGSAWQVSSEDVR 16 0 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 GALQGSAWQVS(0.817)S(0.183)EDVR;GALQGSAWQVS(0.987)S(0.013)EDVR 171.52 4.7125e-07 0.0 11044.1 11948.0 14602.7 18251.9 16847.1 13344.3 14164.9 15590.0 14882.099999999999 14061.3 True False 10430.313135035198 12864.373181124829 13663.178180217614 15765.959733716329 14730.616683015061 15182.35619750542 14823.595917216871 15635.364318936563 17858.935840616723 13655.313733355057 0.7638281579395475 0.9420781852636426 1.0005759257543345 1.1545659105001533 1.0787461182260079 1.1118277100012974 1.0855551330913853 1.145002203848671 1.3078378270426492 1.0 13.737174840218444 -4.061895718607096 0.6770450553750477 1.1397144735437061 8.637783426586711e-11 0.6936057916417843 0.07630407740877768 4.067365800872436 0.694797715770426 0.0315291551729318 4.456885731868985 8.67170072847687e-05 4.061895718607096 -1.1397144734573283 GALQNIIPAS(ph)TGAAK ddPTM_A459_Selumetinib_30min_R1 1 GALQNIIPASTGAAK 15 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 GALQNIIPAS(0.973)T(0.027)GAAK 178.22 1.969e-05 193300000.0 4668.0 8681.8 7058.5 7771.8 6909.5 5852.9 6779.0 7458.1 3463.6 5182.0 True False 4776.755317653158 7665.33081994068 6099.9944695651675 6414.601024754268 6284.536944971302 5794.025140008003 6267.6545721957855 7260.28696067698 5877.4762286648975 5847.160176954452 0.8169359437902685 1.3109493477110865 1.0432405278732089 1.0970455452950107 1.0748015711525558 0.990912676352553 1.071914293865018 1.241677453833421 1.005184747944811 1.0 12.513520397670963 -7.553813145857231 24.999928998579776 1.1054177419433944 1.0662715369615743 0.0 0.12999650684280828 1155.3261528425307 933676.2681161371 0.057782333614281665 0.03336097114803546 2.793745584926676e-08 7.553813145857231 -0.03914620498182009 GALQNIIPAST(ph)GAAK ddPTM_A459_Selumetinib_30min_R1 1 GALQNIIPASTGAAK 15 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 GALQNIIPAS(0.109)T(0.891)GAAK 139.34 0.00092127 181930000.0 2578.3 4915.1 3412.0 4429.9 3226.1 2950.6 3806.7 3908.2 1616.3 2786.7 True False 2638.3693735015295 4339.637807032002 2948.669140774435 3656.3011245218536 2934.2998246142147 2920.919642930449 3519.557554208249 3804.5418403772765 2742.743050118687 3144.400089756653 0.8390692336183321 1.380116296640816 0.9377525304048171 1.1627976784610818 0.9331827187555201 0.9289274772780268 1.1193097105148058 1.2099420340214124 0.872262743870787 1.0 11.61856908075246 -7.560533219554446 0.17448081668414703 0.9784356887348087 1.1041131331797878 0.0074685545589551205 0.16376613046014543 26.145467636128235 3.984198091803031 1.0209634705229274 1.3420856810604882 2.7508491821482167e-08 7.560533219554446 0.12567744444497908 GALQNIIPAST(ph)GAAK ddPTM_A459_Selumetinib_30min_R2 2 GALQNIIPASTGAAK 15 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 GALQNIIPAS(0.155)T(0.845)GAAK;GALQNIIPAS(0.026)T(0.974)GAAK 260.25 5.1876999999999996e-36 246480000.0 999690.0 810840.0 778160.0 895790.0 766400.0 714480.0 846250.0 779230.0 649733.0 783160.0 True False 944131.2318761451 873028.8207384705 728094.0327965487 773781.8566760586 670117.9802970683 812893.1345963209 885602.3018125624 781497.4302915299 779697.7550568412 760548.1359059502 1.2413826124910743 1.1478942351210097 0.9573280091328568 1.0174002408859297 0.881098708497703 1.0688253592627879 1.1644263656732918 1.0275449947170343 1.0251787076278616 1.0 19.53668003499029 -5.038093732512557 3.9647954388851794 1.0212732926424752 1.2287412215213187 0.5306874296004782 0.06897086381010231 0.17300399816947 5.784240749879787 0.019321642558974835 0.06965866993635608 9.16022766261202e-06 5.038093732512557 0.20746792887884347 GALQNIIPASTGAAK ddPTM_A459_Selumetinib_30min_R1 2 GALQNIIPASTGAAK 15 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 220.69 2.7571e-08 113550000.0 6168.9 6465.9 7311.299999999999 7183.1 7013.700000000001 6617.299999999999 6319.6 6617.200000000001 4708.8 5721.2 False True 6312.623367410142 5708.869422084643 6318.465618096166 5928.706428486634 6379.312073369309 6550.735970027674 5842.907484060851 6441.690360305131 7990.489682855209 6455.571749207225 0.9778565884865833 0.8843321155536252 0.978761582019765 0.9183859553903505 0.9881869989521406 1.0147414085874167 0.9050952744469748 0.9978497041871158 1.2377663812405895 1.0 12.656329160708454 -8.03412695469831 12.660315674360382 1.118598407731718 0.9531902041391882 0.5018899807941362 0.06542794958821552 1.390857728511013 513.5301276587322 0.04010704152614094 0.015394890924576323 9.244279019785084e-09 8.03412695469831 -0.16540820359252972 GALQNIIPASTGAAK ddPTM_A459_Selumetinib_30min_R2 2 GALQNIIPASTGAAK 15 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 220.53 2.8407e-08 77651000.0 185088.0 160952.0 185684.0 186387.0 203124.0 139159.0 145728.0 158399.0 151220.0 166706.0 False True 174801.54992596895 173296.50085775045 173737.29359745336 161000.76906449086 177605.74716840027 158326.88909037254 152504.64075455363 158859.9148656339 181468.2254398281 161892.76462579507 1.0797366412885203 1.0704400611004106 1.0731628062503977 0.9944902073705023 1.0970579666047755 0.9779738424773656 0.9420102319400037 0.9812663044752408 1.1209162179624301 1.0 17.304678984031952 -6.770508513305367 24.999628505168005 0.9993610174459716 1.0601531198493066 0.25013314399025455 0.05018186765856033 286.172067540535 788846.4144828257 0.017964922810756553 0.016073027622118038 1.6962563508824208e-07 6.770508513305367 0.06079210240333499 GALSSS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 GALSSSLR 8 0 A0A1W2PR28;Q5JU85-3;Q5JU85;A0A1W2PQS2;A0A1W2PPE7;A0A1W2PPU7;A0A1W2PRJ5 A0A1W2PR28 IQSEC2 IQ motif and SEC7 domain-containing protein 2 1 GALS(0.015)S(0.087)S(0.898)LR 90.601 0.028559 0.0 3102.1 4946.6 2763.4 3368.5 3507.1 3311.2 4322.7 4317.3 2134.6 3772.2 True False 3174.37289436415 4367.4497723880495 2388.145458269656 2780.2547095762575 3189.8834242287953 3277.8923343290508 3996.6352587742645 4202.791179433199 3622.2602949844368 4256.398614339558 0.7457884427623563 1.0260904036746856 0.5610718531446124 0.6531941581340014 0.7494324928784313 0.7701093415654312 0.938971092911701 0.9874054477121202 0.8510152885543318 1.0 12.05541755110312 -7.238354703876912 4.309870053161963 0.9450321603379066 0.7484600494186227 0.4004979265332439 0.11618460012639137 0.23646502492938776 10.776435474469183 0.04987790019648927 0.03617402330593208 5.776240883927826e-08 7.238354703876912 -0.19657211091928395 GALSSS(ph)LRDLSDAGVCY ddPTM_A459_Selumetinib_30min_R1 1 GALSSSLRDLSDAGVCY 17 1 A0A1W2PR28;Q5JU85-3 A0A1W2PR28 IQSEC2 IQ motif and SEC7 domain-containing protein 2 1 GALSS(0.048)S(0.952)LRDLSDAGVCY 163.02 6.1855e-05 16506000.0 1041.0 1457.9 1694.8 1965.0 1587.8 1179.6 974.97 1319.9 626.83 1057.4 True False 1065.2532745666097 1287.208390240678 1464.6554688700212 1621.8496376183296 1444.183770348858 1167.7342949911065 901.4272279471493 1284.891964360567 1063.6847281481753 1193.1275899482139 0.8928242742361239 1.078852254432024 1.2275765653307813 1.3593262374300839 1.2104185524798239 0.9787170331395911 0.7555162042529538 1.0769107806955802 0.8915096232032846 1.0 10.22053261398445 -6.854432746743742 5.362003382544786 0.9288647018394689 1.1645896984363435 0.38275324385991083 0.13574984598647205 0.2292530667351837 10.477073648237644 0.05171120496686066 0.04575414083054265 1.398193417681672e-07 6.854432746743742 0.23572499659687463 GAMGIMLVY(ph)DITNGKS(ph)FENIS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GAMGIMLVYDITNGKSFENISK 22 1 P61026 P61026 RAB10 Ras-related protein Rab-10 3 GAMGIMLVY(0.996)DIT(0.188)NGKS(0.822)FENIS(0.994)K 52.298 0.036468 0.0 0.0 0.0 0.0 962.31 728.71 0.0 577.74 0.0 0.0 0.0 True False 0.0 0.0 0.0 831.2417179226575 637.1629350499437 0.0 604.6060547700914 0.0 0.0 0.0 0.0 GAMPPAPVPAGTPAPPGPATMMPDGTLGLT(ph)PPTTER ddPTM_A459_Selumetinib_30min_R1 1 GAMPPAPVPAGTPAPPGPATMMPDGTLGLTPPTTER 36 0 Q15233-2;Q15233 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 1 GAMPPAPVPAGTPAPPGPAT(0.086)MMPDGT(0.028)LGLT(0.78)PPT(0.053)T(0.053)ER 86.277 5.4094e-09 10490000.0 775.36 669.16 941.42 883.55 933.52 570.1 935.73 663.42 317.52 575.26 True False 793.4243794120721 590.814436115956 813.5803348499027 729.2545787876212 849.0832808263422 564.3653116093843 865.1471327394545 645.8239465081352 538.8082492567501 649.1002245069125 1.2223449468297367 0.9102052561524946 1.2533970935966585 1.1234853282350932 1.3080927240032099 0.8694578900170665 1.3328406000732191 0.9949525853249149 0.8300848296055583 1.0 9.342297444941405 -7.990118152172426 24.99676930491401 0.9142011373720712 1.137567985488963 0.28748379431149773 0.15034152759383523 230.61786625268115 583362.5687839303 0.07685866512657796 0.03685561046316808 1.0230146377304199e-08 7.990118152172426 0.2233668481168919 GANDFMCDEMER ddPTM_A459_Selumetinib_30min_R1 4 GANDFMCDEMER 12 0 F5H282;E7EQR6;P17987;F5GZ03;E7ERF2 F5H282 TCP1 T-complex protein 1 subunit alpha 0 ;;; 293.88 3.931999999999999e-54 51062000.0 7035.400000000001 11098.2 8296.5 10314.0 9155.9 7718.9 8515.8 6738.200000000001 3589.0 5405.9 False True 7199.31113149465 9798.8175845868 7169.880869412399 8512.853517758507 8327.750461605434 7641.254874200446 7873.4463498900905 6559.481047241746 6090.2708698112765 6099.799922925138 1.1802536513430828 1.6064162281388095 1.1754288599640015 1.3955955318738058 1.365249773243692 1.2527058216257212 1.290771246495968 1.0753600331363278 0.9984378089061499 1.0 12.574546206856038 -7.783041735607044 1.5102928358107812 0.983367104665022 1.3448172692471292 0.5852150473901347 0.11652243737883654 0.27192038913447353 1.1552207033647763 0.088037042295525 0.033753916535883464 1.6480040110816436e-08 7.783041735607044 0.3614501645821072 GANDFMCDEMER ddPTM_A459_Selumetinib_30min_R2 4 GANDFMCDEMER 12 0 F5H282;E7EQR6;P17987;F5GZ03;E7ERF2 F5H282 TCP1 T-complex protein 1 subunit alpha 0 ;;; 243.53 1.6604e-11 10951800.0 35929.8 43612.0 46491.100000000006 44857.5 50395.3 39418.2 32365.199999999997 37714.2 33095.0 44637.9 False True 33932.9655543854 46956.900165317704 43499.91324168238 38747.831116496374 44064.19187430176 44847.69924720732 33870.24593042715 37823.94207807807 39714.92475156131 43349.08784380745 0.7827838425724298 1.083226948961641 1.0034793211432353 0.8938557428499991 1.016496403178561 1.0345707713343257 0.7813369926598263 0.8725429751685383 0.9161651773310544 1.0 15.403714015970937 -7.245110600931114 24.952867967847556 0.8818898541979622 0.9745589736250738 0.13427241979253368 0.09306935515918247 1344.4331064443338 2054501.8722130738 0.034556478642251025 0.026687468898263362 5.6870808061936285e-08 7.245110600931114 0.09266911942711165 GAPLS(ph)PSAENR ddPTM_A459_Selumetinib_30min_R2 2 GAPLSPSAENR 11 0 Q96MN9 Q96MN9 ZNF488 Zinc finger protein 488 1 GAPLS(0.949)PS(0.051)AENR;GAPLS(0.676)PS(0.324)AENR 107.97 0.010242 11938500.0 101992.0 110822.0 113087.0 108999.0 114480.0 137049.0 97810.0 94109.0 80746.0 118522.0 True False 96323.69294632525 119321.69105110598 105811.10553981616 94153.14816623717 100097.9989358147 155926.25574304527 102358.35880683806 94382.84160941633 96897.45623174397 115099.96190286154 0.8368698942543308 1.036678805782815 0.9192974853381385 0.8180119837545871 0.869661442809966 1.354702930958735 0.889299675817645 0.8200075834001631 0.8418548071590193 1.0 16.81252783038687 -12.157543355311349 2.168508550389076 2.4927519166867955 0.9372592360811955 0.01616072856580808 0.15442913643855077 7425364.086521387 1197286.150094788 54295914.2267548 0.03981737880427603 6.9575549445404e-13 12.157543355311349 -1.5554926806056 GAPPGS(ph)PEPPALLAAPLAAGACPGGR ddPTM_A459_Selumetinib_30min_R1 1 GAPPGSPEPPALLAAPLAAGACPGGR 26 0 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 GAPPGS(1)PEPPALLAAPLAAGACPGGR 124.39 5.0707e-09 2711100.0 594.22 713.34 635.09 786.0 576.27 660.35 515.52 581.32 427.57 725.08 True False 608.0641698491556 629.821821177231 548.8482662996586 648.7398550473321 524.1464802487317 653.7074785498276 476.6339113524666 565.9015052065193 725.5550615227661 818.1510808772933 0.7432174619840823 0.7698111460072641 0.6708397496842946 0.7929340560813002 0.6406475435890103 0.7990058240207482 0.5825744443695875 0.6916833802868171 0.886822835636619 1.0 9.676223467546244 -8.444984032771785 3.3175776743578234 0.9971876387725392 0.7112369264829601 0.6815570816722937 0.06555667867623008 0.12161823905983878 2.633375168527178 0.06104044121269674 0.0162264018340396 3.589351309761455e-09 8.444984032771785 -0.28595071228957913 GAPPGS(ph)PEPPALLAAPLAAGACPGGR ddPTM_A459_Selumetinib_30min_R2 2 GAPPGSPEPPALLAAPLAAGACPGGR 26 0 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 GAPPGS(1)PEPPALLAAPLAAGACPGGR;GAPPGS(1)PEPPALLAAPLAAGACPGGR 144.23 3.1345e-10 21049500.0 66502.0 60782.0 68888.0 64206.0 75535.0 58129.0 47581.0 55491.0 50557.0 69367.0 True False 62806.085068598615 65443.78395506601 64455.82107958331 55461.03203847217 66045.61800853221 66135.7421074761 49793.610779962844 55652.46962297043 60669.812680606876 67364.19447288943 0.9323363184261749 0.9714921178401934 0.9568261237878144 0.8233013468422359 0.9804261525774218 0.9817640161063943 0.7391702842969817 0.8261431767786912 0.900624035592429 1.0 16.0396943510422 -7.2226292627987485 24.997778390524047 0.8519961294426687 0.9395674523236811 0.18225956153517764 0.07483649654440104 786.6991858620011 506717.2158708242 0.028304888554449844 0.0219245320507144 5.989226495847986e-08 7.2226292627987485 0.08757132288101244 GAPPPAASASAAAS(ph)GGEDEEEASSPDSGHLK ddPTM_A459_Selumetinib_30min_R1 1 GAPPPAASASAAASGGEDEEEASSPDSGHLK 31 0 Q7RTV3;Q7RTV3-2 Q7RTV3;Q7RTV3-2 ZNF367 Zinc finger protein 367 1 GAPPPAASAS(0.001)AAAS(0.999)GGEDEEEASSPDSGHLK 121.26 2.2605e-16 5044100.0 540.18 752.76 528.25 710.32 699.1 540.39 612.76 595.98 175.32 456.04 True False 552.7651429926908 664.6265092513705 456.5165514695472 586.2759463577872 635.8665284361301 534.9541672348624 566.5390198640939 580.1726743841282 297.50523513382916 514.577176205772 1.0742123214023933 1.2915973346349818 0.8871682860784186 1.1393353095850172 1.2357068246296572 1.039599484725187 1.100979689852282 1.1274745581644792 0.5781547431378128 1.0 9.00724365830197 -8.2366201111585 24.596376046233402 0.7890773715127306 1.1127536412827783 0.46127456159761404 0.13959474274629957 442.3004445786593 438329.8545502057 0.08837261990154553 0.03336733885859665 5.799357597334589e-09 8.2366201111585 0.3236762697700477 GAPPPAASASAAAS(ph)GGEDEEEASSPDSGHLK ddPTM_A459_Selumetinib_30min_R2 2 GAPPPAASASAAASGGEDEEEASSPDSGHLK 31 0 Q7RTV3;Q7RTV3-2 Q7RTV3;Q7RTV3-2 ZNF367 Zinc finger protein 367 1 GAPPPAAS(0.012)AS(0.283)AAAS(0.706)GGEDEEEASSPDSGHLK;GAPPPAAS(0.003)AS(0.103)AAAS(0.894)GGEDEEEASSPDSGHLK 141.21 9.6015e-19 12342200.0 20105.8 17851.8 28389.9 31388.4 32310.0 26991.0 22543.8 22052.5 22052.4 29726.0 True False 18988.400125894423 19220.97565741581 26563.32474258596 27113.245771989834 28250.92894493513 30708.76525009696 23592.131369692237 22116.66912401209 26463.496195537995 28867.733142576606 0.6577724697714038 0.6658290612042228 0.9201735588794152 0.9392232371720555 0.9786334384277732 1.0637747376431523 0.8172491845193255 0.7661380619939475 0.9167154228853309 1.0 14.817170203009583 -5.25925342181017 7.602983442209043 0.920561747806212 0.66084028781869 0.6300842403346381 0.08068150101884795 0.08128760768689383 42.85401813207806 0.023122810383582153 0.05487606940875682 5.504863799461011e-06 5.25925342181017 -0.25972145998752205 GAPS(ph)SPATGVLPS(ph)PQGK ddPTM_A459_Selumetinib_30min_R2 1 GAPSSPATGVLPSPQGK 17 0 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 2 GAPS(0.5)S(0.5)PAT(0.001)GVLPS(1)PQGK 172.6 2.4587e-07 0.0 27184.0 21266.0 28134.0 25679.0 23911.0 23150.0 32971.0 25983.0 23875.0 27572.0 True False 25673.22210617404 22897.033819032516 26323.88906998313 22181.475901254198 20907.086412947825 26338.702365223395 34504.21683079707 26058.606228282795 28650.667123236897 26775.92471934072 0.958817384470379 0.8551351282554804 0.9831178323775658 0.8284111990064018 0.7808165967036153 0.9836710642601444 1.288628392575143 0.9732103186509262 1.0700159723164302 1.0 14.708648779547207 -7.0006419054538425 24.999703330619763 1.0886481331357258 0.8825022890902555 0.4970694062667521 0.09564826762280226 19.19690181891968 747676.7881596612 0.0335266111830509 0.029225505456814082 9.985230498368847e-08 7.0006419054538425 -0.20614584404547032 GAPS(ph)SPATGVLPSPQGK ddPTM_A459_Selumetinib_30min_R1 1 GAPSSPATGVLPSPQGK 17 0 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 1 GAPS(0.681)S(0.319)PATGVLPSPQGK 338.92 1.3916999999999992e-154 22531000.0 2172.0 3073.3 2849.7 2795.4 2578.8 2393.7 2385.7 2446.8 1320.3 1932.6 True False 2222.6033740237053 2713.476607261592 2462.726392281626 2307.235866156887 2345.547995324118 2369.621551305707 2205.7447282619114 2381.9029156734878 2240.4526691033225 2180.668035118136 1.019230501034651 1.2443327290366744 1.1293449312876318 1.0580408521611104 1.0756098395311462 1.086649372185315 1.0114995463499867 1.0922812997277003 1.0274157428010118 1.0 11.090554448707477 -5.732954292481258 4.789833771115417 1.054658704162088 1.1441872385631486 0.27886278392572894 0.05845169568282625 0.2208081874536516 12.181493415690383 0.01532791759392315 0.02609029361949378 1.8494632563306122e-06 5.732954292481258 0.08952853440106057 GAPSQDDES(ph)GGIEDSPDR ddPTM_A459_Selumetinib_30min_R2 2 GAPSQDDESGGIEDSPDR 18 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GAPSQDDES(1)GGIEDSPDR;GAPSQDDES(1)GGIEDSPDR 187.73 2.0022e-10 11957200.0 14550.3 10938.4 13738.0 16289.6 14992.7 12847.3 12542.900000000001 14207.599999999999 13947.9 11531.8 True False 13741.652575465874 11777.340107500473 12854.112036803448 14070.928378872628 13109.182989561412 14616.89895882222 13126.169703284842 14248.941763805195 16737.86973688779 11198.846970785338 1.2270595902697845 1.051656490906989 1.1478067403131977 1.2564622425486969 1.1705832773462845 1.3052146347703137 1.1721001043703294 1.2723579312206605 1.494606523381578 1.0 13.451062580121421 -5.714843313156654 5.326992097095759 1.247401110034239 1.13074834510909 0.10927834378773105 0.12393216932009792 0.3676426225694174 23.348644585677135 0.0329234476501318 0.05675860086986124 1.928220460325363e-06 5.714843313156654 -0.11665276492514898 GAPSQDDESGGIEDS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 1 GAPSQDDESGGIEDSPDR 18 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GAPSQDDESGGIEDS(1)PDR 148.69 0.00018819 4317200.0 874.15 1041.4 1076.9 863.24 1121.6 925.43 1130.9 946.16 592.74 956.78 True False 894.5159942001945 919.4724038662749 930.662894988273 712.4913390217037 1020.1514780345626 916.1210144232109 1045.5953025071867 921.0647632391804 1005.8364879832636 1079.5920328264147 0.8285685397828625 0.8516850587152444 0.8620505401024132 0.6599635022837035 0.9449416511196046 0.8485807476966738 0.9685096506036422 0.8531600227057959 0.931682021911503 1.0 10.076270519817509 GAPSQDDESGGIEDS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 2 GAPSQDDESGGIEDSPDR 18 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 GAPSQDDESGGIEDS(1)PDR;GAPSQDDESGGIEDS(1)PDR 271.58 4.2173e-54 20717900.0 29120.4 15838.7 18647.4 23620.0 22174.9 19989.3 28203.0 29985.0 30732.4 18401.4 True False 27502.004746197435 17053.477360552537 17447.646585754017 20402.915253227293 19389.090815878753 22742.644630201296 29514.495383184305 30072.25138571601 36879.73873500171 17870.10376942101 1.538995245973801 0.9543020891537368 0.9763595562108658 1.141734570570339 1.0850015795127617 1.2726643853696076 1.6516129824432784 1.6828246647999374 2.0637674638526518 1.0 14.12526039149989 -7.154593310666339 2.980298990805521 1.6622414532672871 1.1219565929399706 0.35574070910970257 0.28755173774255516 0.25442313412885037 4.342884803663311 0.11664740219588587 0.08590271701983093 7.004976607459158e-08 7.154593310666339 -0.5402848603273165 GAPSS(ph)PATGVLPS(ph)PQGK ddPTM_A459_Selumetinib_30min_R2 1 GAPSSPATGVLPSPQGK 17 0 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 2 GAPS(0.031)S(0.954)PAT(0.015)GVLPS(1)PQGK 161.95 0.00033557 3041100.0 17912.0 17536.0 20258.0 21482.0 22347.0 16251.0 17165.0 18397.0 16063.0 20760.0 True False 16916.522747417224 18880.95481287286 18954.622335242693 18556.114541483028 19539.57007528522 18489.427738109964 17963.20651180224 18450.532224212697 19276.04883771957 20160.60485904226 0.8390880564195955 0.9365271996987995 0.9401812330417918 0.9204145744248541 0.9691956274080488 0.9171067965164371 0.8910053362682487 0.9151775134334534 0.9561245296206498 1.0 14.299251302814376 GAPSS(ph)PATGVLPSPQGK ddPTM_A459_Selumetinib_30min_R1 3 GAPSSPATGVLPSPQGK 17 0 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 1 GAPS(0.012)S(0.937)PAT(0.051)GVLPSPQGK;GAPS(0.363)S(0.637)PATGVLPSPQGK;GAPS(0.002)S(0.966)PAT(0.032)GVLPSPQGK 279.19 1.2434999999999992e-63 46026400.0 15844.1 20775.7 19893.4 20485.2 18649.0 17491.4 18211.6 17023.3 9796.3 15529.8 True False 16213.236702748141 18343.2713856391 17191.9855466243 16907.84437482902 16962.201242748368 17315.452396920507 16837.884349756725 16571.786784528555 16623.605606556743 17523.201103062005 0.925244001218193 1.0467991138008337 0.9810984560132777 0.9648833152907514 0.9679853094754698 0.9881443632975715 0.9608908926357338 0.9457054499952523 0.9486626050106755 1.0 14.096978727186258 -5.5272180802009485 18.173841733409166 0.966827639480777 0.9930031623345645 0.04544041396117893 0.03139521851555734 8.512205793430953 35649.93211460195 0.00812146307842323 0.014253889146172432 2.9701741895247084e-06 5.5272180802009485 0.026175522853787547 GAPSS(ph)PATGVLPSPQGK ddPTM_A459_Selumetinib_30min_R2 4 GAPSSPATGVLPSPQGK 17 0 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 1 GAPS(0.001)S(0.935)PAT(0.064)GVLPSPQGK;GAPSS(0.999)PATGVLPSPQGK;GAPS(0.052)S(0.806)PAT(0.142)GVLPSPQGK;GAPS(0.004)S(0.995)PAT(0.002)GVLPSPQGK 217.32 9.4785e-12 102616700.0 266027.0 222116.0 283159.0 310238.0 331685.0 254361.0 232070.0 269687.0 228726.0 283100.0 True False 251242.28433045777 239151.58298449343 264940.85822020855 267983.0492095986 290015.76499847777 289396.9188907383 242861.71483798124 270471.74452091375 274477.59113840794 274926.1674178638 0.9138536600213519 0.8698756660038253 0.9636800334743021 0.974745517047447 1.054885999838928 1.0526350460153915 0.8833706777312784 0.9837977485417759 0.998368375467243 1.0 18.068684703249602 -5.439759458464025 3.1967825062240007 0.9918747423709984 0.8919682866448533 0.426096540176076 0.04587576740915498 0.2532994796685932 4.931209027530175 0.013413948027063612 0.030826651993931142 3.6327920755278607e-06 5.439759458464025 -0.0999064557261451 GAPTTPAATPPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GAPTTPAATPPSPK 14 0 E9PAV3 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 GAPT(0.003)T(0.154)PAATPPS(0.842)PK 133.48 0.0010876 0.0 18716.0 23254.0 23081.0 22680.0 21246.0 17531.0 18228.0 21287.0 16063.0 22141.0 True False 17675.83964608422 25037.50702660501 21595.99358869269 19590.944874817756 18576.887538350114 19945.736119426834 19075.638118096784 21348.941645747444 19276.04883771957 21501.73180077335 0.8220658600833481 1.1644414160958185 1.00438391608605 0.9111333475991517 0.8639716889074937 0.9276339368491914 0.8871675218928502 0.9928940535375662 0.8964881999424005 1.0 14.39216524214413 -5.730595167424689 7.073886132764176 0.9212024313441138 1.0144488650543546 0.11267100529975127 0.08724599792200953 0.30513980173361155 49.321604787240105 0.0226676052506628 0.03861914205556747 1.859537036189274e-06 5.730595167424689 0.09324643371024077 GAPVNIS(ph)SSDLTGR ddPTM_A459_Selumetinib_30min_R1 2 GAPVNISSSDLTGR 14 0 P48730-2;H7BYT1;P48730;J3KRM8 P48730-2 CSNK1D Casein kinase I isoform delta 1 GAPVNIS(0.779)S(0.213)S(0.007)DLT(0.001)GR;GAPVNIS(0.747)S(0.227)S(0.021)DLT(0.004)GR 154.47 0.00034358 62082000.0 3125.5 3243.6000000000004 2948.8999999999996 3758.5 3767.2 2980.3 3102.3999999999996 3002.1 1681.23 2992.5 True False 3198.3180688356756 2863.8378040912694 2548.455577148221 3102.148530782949 3426.4574251531817 2950.3208878958894 2868.3834702434283 2922.47455580488 2852.9245178191168 3376.6165244184117 0.9471961194606052 0.8481383015752838 0.7547364525165222 0.9187150830866893 1.01476060440217 0.8737506514465846 0.849484520821469 0.8655038363612364 0.844906283312851 1.0 11.721362629321733 -12.003394353175919 2.1717413916205004 2.34101455686101 0.8787254426734258 0.23116666575565004 0.06580284423339834 2198801.7421405734 259496.70269808726 14624661.307570936 0.018028636111738477 9.922146768221936e-13 12.003394353175919 -1.4622891141875844 GAPVNISSS(ph)DLTGR ddPTM_A459_Selumetinib_30min_R2 2 GAPVNISSSDLTGR 14 0 P48730-2;H7BYT1;P48730;J3KRM8 P48730-2 CSNK1D Casein kinase I isoform delta 1 GAPVNIS(0.369)S(0.22)S(0.396)DLT(0.015)GR;GAPVNIS(0.009)S(0.013)S(0.979)DLTGR 149.31 0.00018614 11239000.0 43867.0 38791.0 46369.0 49019.0 49795.0 36672.0 38651.0 42068.0 42348.0 46507.0 True False 41429.04775351444 41766.14496727593 43385.66902274996 42342.52763750843 43539.30692705187 41723.23512472885 40448.34808550354 42190.410915267705 50818.783301982665 45164.22207030244 0.9172979374918968 0.924761748409237 0.9606203103690351 0.9375236790661029 0.964022071702658 0.9238116635726092 0.8955838544620962 0.9341555988630621 1.125200013915403 1.0 15.462892738892647 -8.242202925089071 24.400772489646663 1.0625999905009975 0.9326551194390631 0.7049965097594099 0.03373432853780441 259.3206673566654 328940.69075472315 0.021771564889348075 0.00819967456443216 5.725284532494836e-09 8.242202925089071 -0.12994487106193442 GAQASS(ph)GSPALPR ddPTM_A459_Selumetinib_30min_R2 1 GAQASSGSPALPR 13 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 GAQAS(0.17)S(0.521)GS(0.309)PALPR 98.943 0.012145 11147000.0 31728.0 28655.0 36392.0 34195.0 35635.0 27228.0 33083.0 32032.0 26236.0 37399.0 True False 29964.6847772473 30852.7463596528 34050.578340613705 29537.58201033479 31158.21271905799 30978.409848825188 34621.42505272085 32125.207816816917 31483.933095088727 36319.193695728405 0.8250371698304394 0.8494887474135052 0.9375367367976146 0.8132774713500532 0.8578993515134833 0.8529487220546044 0.9532542308832359 0.8845242569521924 0.8668676226364473 1.0 15.148444553982067 -14.522878745168862 0.15561885344812385 1.468061607791796 0.8361896497347535 0.5029799570534208 0.04033097379055406 116.90271834445896 1.057052626670966 16.86073677296542 0.18875590899440448 3.0000000007700452e-15 14.522878745168862 -0.6318719580570425 GAQASSGS(ph)PALPR ddPTM_A459_Selumetinib_30min_R1 3 GAQASSGSPALPR 13 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 GAQAS(0.018)S(0.037)GS(0.944)PALPR;GAQAS(0.072)S(0.225)GS(0.703)PALPR;GAQAS(0.041)S(0.178)GS(0.781)PALPR 127.66 0.0019042 86113000.0 7258.1 9254.7 8866.7 9416.9 9117.3 7266.1 8508.8 7739.4 3936.4 6076.0 True False 7427.199608195882 8171.155421606699 7662.650841296795 7772.415192105883 8292.641824790053 7193.009631090946 7866.9743655258135 7534.125970885807 6679.78329671917 6855.913785251888 1.0833274514292925 1.1918404573849946 1.1176702451802007 1.1336804159972853 1.2095604006323395 1.0491686238184912 1.1474727675906413 1.0989236747832005 0.9743096990350723 1.0 12.743133251992953 -8.154278149698387 3.601165483876927 0.9863785517616762 1.1341850456288491 0.6243207673557889 0.04453573812604421 0.14867822619555987 3.3612263615782214 0.03394673167242727 0.011174501576809008 7.010061858457066e-09 8.154278149698387 0.14780649386717293 GAQASSGS(ph)PALPR ddPTM_A459_Selumetinib_30min_R2 3 GAQASSGSPALPR 13 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 GAQAS(0.021)S(0.074)GS(0.905)PALPR;GAQAS(0.141)S(0.19)GS(0.669)PALPR;GAQAS(0.055)S(0.089)GS(0.856)PALPR 117.48 0.003607500000000001 154802000.0 83658.0 75699.0 89495.0 97997.0 101952.0 76388.0 80267.0 81500.0 64372.0 82763.0 True False 79008.62326950819 81504.8698893513 83736.98913478854 84649.63954574578 89143.87829755576 86909.75361877694 83999.57454604309 81737.15150694865 77248.19870395846 80373.41714590139 0.983019337427004 1.0140774497791478 1.0418493092409058 1.0532044368859146 1.1091214167954735 1.0813246058831887 1.0451163771419494 1.016967480162896 0.9611162676302573 1.0 16.29443080019228 -7.97553284672839 3.226437650045872 0.9811921787186269 1.0492565240846008 0.38354622785315085 0.03337925393452416 0.2810857978745758 5.9008239011488 0.02630079363285142 0.010107331690046368 1.0579548973158923e-08 7.97553284672839 0.06806434536597394 GAQKT(ph)DCQK ddPTM_A459_Selumetinib_30min_R1 1 GAQKTDCQK 9 1 A0A087X1T8;A0A087WUG3;Q7L266-2;Q7L266 A0A087X1T8 ASRGL1 Isoaspartyl peptidase/L-asparaginase;Isoaspartyl peptidase/L-asparaginase alpha chain;Isoaspartyl peptidase/L-asparaginase beta chain 1 GAQKT(1)DCQK 94.114 0.032767000000000004 11510000.0 2444.3 2923.3 3178.3 3594.9 2887.2 2409.3 2558.7 2677.1 1489.4 2023.5 True False 2501.247434220139 2581.0386769946995 2746.7043171522214 2967.1181996306054 2626.0532697765607 2385.0646294693715 2365.6951989788117 2606.0946115536585 2527.403018527977 2283.235935559117 1.0954835614076106 1.1304301219149553 1.2029875118795423 1.2995232570671764 1.150145383084773 1.0445984106698631 1.0361150865468933 1.141403992012538 1.1069390504792789 1.0 11.156864231160293 -6.610370048610873 5.530675409953868 1.0736012367956174 1.1850563424309084 0.4463369649502382 0.06157462461172689 0.22026995444277175 10.84735036495522 0.022164193695284447 0.022160534909623022 2.4526182265813264e-07 6.610370048610873 0.11145510563529104 GAQPGRHS(ph)VTGYGDCAVGAR ddPTM_A459_Selumetinib_30min_R1 1 GAQPGRHSVTGYGDCAVGAR 20 1 Q96IF1;H0YJL9 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 GAQPGRHS(0.997)VT(0.003)GYGDCAVGAR 88.555 0.0010798 46021000.0 1446.2 1886.9 1724.2 1686.5 1996.2 1554.6 1872.5 1576.2 1042.4 1581.7 True False 1479.8936461846608 1665.9808708039877 1490.0631103526605 1391.9844345258591 1815.6440624577344 1538.9621354638634 1731.2558174416015 1534.3940557808357 1768.876666116265 1784.72660206269 0.82919907423035 0.9334655901237409 0.8348971257729484 0.7799426718451326 1.0173233594206035 0.8622957340834246 0.9700397895345484 0.8597361937719012 0.9911191238321283 1.0 10.801487372889751 -7.660276058790089 0.2937633013428549 1.0111485266199727 0.8383593110591318 0.30894632627877006 0.06660338885361552 2.2133738048080884 0.6503876956895018 0.11900762733984253 0.13942764686209383 2.1863714176669323e-08 7.660276058790089 -0.17278921556084093 GARPPAAGPGGDEDEDEEDTAPESALDT(ph)SLDK ddPTM_A459_Selumetinib_30min_R1 1 GARPPAAGPGGDEDEDEEDTAPESALDTSLDK 32 1 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 GARPPAAGPGGDEDEDEEDT(0.001)APES(0.136)ALDT(0.473)S(0.39)LDK 90.246 2.1567e-07 4319200.0 454.28 298.16 292.36 390.31 571.32 275.78 414.82 492.36 461.36 426.23 True False 464.8638401249948 263.25128858917645 252.65911781852682 322.14968552611225 519.6442068747383 273.00590358820557 383.5297934265021 479.301013389324 782.8942235988105 480.9407723317824 0.9665719083685906 0.5473673760551322 0.5253435191063965 0.6698323453929867 1.0804744300536364 0.5676497383754134 0.7974574323715682 0.9965905179248824 1.6278391615729393 1.0 8.909715427378325 -7.958046861931534 3.382550506569208 1.320235720130699 0.7256776813588692 0.5156341442696833 0.22225890084839153 0.17791765101511367 4.12183495444129 0.14659937840226533 0.058440166433761466 1.1014204559134025e-08 7.958046861931534 -0.5945580387718297 GARPPAAGPGGDEDEDEEDTAPESALDT(ph)SLDK ddPTM_A459_Selumetinib_30min_R2 1 GARPPAAGPGGDEDEDEEDTAPESALDTSLDK 32 1 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 GARPPAAGPGGDEDEDEEDT(0.001)APES(0.209)ALDT(0.431)S(0.359)LDK 63.727 0.00047855 5660800.0 9305.5 6419.8 7127.7 8870.4 7950.9 8073.0 11860.0 12158.0 10002.0 6549.4 True False 8788.337562867964 6912.178017089478 6669.111542052985 7662.236217706493 6952.036860052151 9184.982470602523 12411.513500144156 12193.377767134742 12002.67947922998 6360.301804615191 1.3817485133316993 1.0867688718912414 1.0485526861655707 1.2046969551266555 1.0930356881819008 1.4441111055355382 1.9514032323337325 1.9171067885940456 1.8871242038421105 1.0 12.634879509557104 -6.999696758938685 3.990993516475689 1.7629390962800686 1.1579659661593624 0.4464159475089272 0.27083102591782765 0.16819441858488174 6.143577404510573 0.09816915108770415 0.08074200188264005 1.0006984821725077e-07 6.999696758938685 -0.6049731301207062 GARPPAAGPGGDEDEDEEDTAPESALDTS(ph)LDK ddPTM_A459_Selumetinib_30min_R2 2 GARPPAAGPGGDEDEDEEDTAPESALDTSLDK 32 1 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 GARPPAAGPGGDEDEDEEDTAPES(0.001)ALDT(0.272)S(0.727)LDK;GARPPAAGPGGDEDEDEEDT(0.001)APES(0.087)ALDT(0.296)S(0.616)LDK 98.667 4.274600000000001e-09 21468000.0 71349.0 48863.0 57798.0 61945.0 67477.0 62285.0 91941.0 94830.0 68534.0 61769.0 True False 67383.70821267704 52610.63498069148 54079.33960570429 53507.984138914675 58999.9360079662 70864.19338306421 96216.43867763536 95105.93960004841 82242.7149999546 59985.56847486425 1.1233319934429367 0.8770548703349692 0.901539169848247 0.8920142877588318 0.9835688401067489 1.1813540353920031 1.6039931124092444 1.5854803416575212 1.371041687042055 1.0 15.872327833703075 -6.96040974264973 3.1906442127081758 1.4377076703250826 0.944378878376784 0.5825859628677503 0.17084484230339952 0.15390686730979591 3.2263883544029412 0.06406043941909054 0.053460048092658724 1.095444192652017e-07 6.96040974264973 -0.4933287919482986 GARS(ph)PEDGPSAR ddPTM_A459_Selumetinib_30min_R2 1 GARSPEDGPSAR 12 1 H0YEB0;Q8TDY4-2;Q8TDY4-3;Q8TDY4 H0YEB0 ASAP3 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 1 GARS(1)PEDGPSAR 115.24 0.025182 1404900.0 7064.6 8079.7 7933.4 9042.7 9559.5 6180.6 4402.0 5644.2 5235.6 7127.7 True False 6671.977813834509 8699.387009669752 7422.973681232818 7811.068660472418 8358.550146985692 7031.921548099337 4606.701722397524 5660.62368755239 6282.866294886667 6921.904781011345 0.9638933248746135 1.2567909101457913 1.0723888750385646 1.1284565314883108 1.2075505820183272 1.0158940018056586 0.6655251506832268 0.817784102301004 0.9076788100469493 1.0 12.756953380325 -7.02962948901312 6.901544182358495 0.8327035750135039 1.1289007983513442 0.5983077582304372 0.10714389145526722 0.12524625184870472 21.36953024371063 0.038691569787856456 0.03083294153934288 9.340508306332185e-08 7.02962948901312 0.29619722333784027 GAS(ph)PLGPGSAAGSGAAASGGLGLGLGGR ddPTM_A459_Selumetinib_30min_R1 2 GASPLGPGSAAGSGAAASGGLGLGLGGR 28 0 B4E1M0;E9PPE2;A0A6I8PS01;Q6P1R3-3;Q6P1R3 B4E1M0 MSANTD2 Myb/SANT-like DNA-binding domain-containing protein 2 1 GAS(1)PLGPGSAAGSGAAASGGLGLGLGGR;GAS(1)PLGPGSAAGSGAAASGGLGLGLGGR 258.2 3.4152999999999984e-72 29448000.0 3003.07 3777.36 3864.5099999999998 3794.04 3439.2400000000002 3202.6299999999997 3828.5 2986.43 1521.15 2765.3599999999997 True False 3073.0356880429867 3335.104935152978 3339.7307682339415 3131.4821369513734 3128.1613492471374 3170.4144499553777 3539.7131626569662 2907.220175108213 2581.280449599726 3120.3208928874515 0.984846044215437 1.0688339595953453 1.0703164459292054 1.003576953924631 1.0025127083491823 1.0160539761093517 1.1344067755100091 0.9317055119987863 0.8272483947031123 1.0 11.607478687714904 -7.939207851722516 9.315995182842208 0.9022859584621665 1.0383981840129621 0.4854681287239728 0.05675603448732181 0.23774945673530243 34.112178087572545 0.02991471697457266 0.014329816052526242 1.1502497519386955e-08 7.939207851722516 0.1361122255507956 GAS(ph)PLGPGSAAGSGAAASGGLGLGLGGR ddPTM_A459_Selumetinib_30min_R2 1 GASPLGPGSAAGSGAAASGGLGLGLGGR 28 0 B4E1M0;E9PPE2;A0A6I8PS01;Q6P1R3-3;Q6P1R3 B4E1M0 MSANTD2 Myb/SANT-like DNA-binding domain-containing protein 2 1 GAS(0.85)PLGPGS(0.147)AAGS(0.002)GAAAS(0.001)GGLGLGLGGR 89.20100000000002 1.9533e-05 6880800.0 23517.0 21502.0 22157.0 25682.0 25066.0 20767.0 20921.0 20490.0 16738.0 19311.0 True False 22210.01928600997 23151.1342601729 20731.442742717572 22184.06729607889 21916.984987116823 23627.465745943606 21893.86795417505 20549.622507697903 20086.06769879538 18753.441253996403 1.1843170000213674 1.234500588271464 1.1054740547044748 1.182933147875002 1.168691371907343 1.2599002724851118 1.1674586897223151 1.09577875491618 1.0710603684278475 1.0 14.1948677338 -8.11823547517102 1.4846577975778632 1.0124080779156701 1.1879746485419753 0.7080627129994619 0.04032463158457455 0.22423451180814657 0.8937650702868704 0.037992515591569756 0.01211985582004905 7.616659215514459e-09 8.11823547517102 0.1755665706263052 GAS(ph)QAGMTGYGMPR ddPTM_A459_Selumetinib_30min_R1 1 GASQAGMTGYGMPR 14 0 P37802;P37802-2;C9J5W6;Q9UI15 P37802 TAGLN2;TAGLN3 Transgelin-2;Transgelin-3 1 GAS(1)QAGMTGYGMPR 87.13799999999998 0.02244 13534000.0 1596.3 1646.3 2290.0 2612.7 1856.8 1588.6 1489.3 1991.7 1015.0 1348.1 True False 1633.4906841409024 1453.5504306558933 1979.0305780695949 2156.440991453135 1688.852767844666 1572.6201263333935 1376.9609019576917 1938.8736460466257 1722.380867333085 1521.141766606001 1.0738582819835236 0.955565393420944 1.3010165268719454 1.4176462962190732 1.1102533668593328 1.0338419211525904 0.9052153666321264 1.2746173227316449 1.132294770379024 1.0 10.570938899557824 -6.508434067597801 24.840033755860834 1.0756575408755327 1.1892963088093529 0.12668208046264395 0.1455668635336113 1543.9445210976858 2655075.6575195324 0.05037853319684643 0.05505137977549752 3.101458200565941e-07 6.508434067597801 0.11363876793382022 GASPLGPGS(ph)AAGSGAAASGGLGLGLGGR ddPTM_A459_Selumetinib_30min_R2 1 GASPLGPGSAAGSGAAASGGLGLGLGGR 28 0 B4E1M0;E9PPE2;A0A6I8PS01;Q6P1R3-3;Q6P1R3 B4E1M0 MSANTD2 Myb/SANT-like DNA-binding domain-containing protein 2 1 GAS(0.101)PLGPGS(0.784)AAGS(0.112)GAAAS(0.003)GGLGLGLGGR 119.04 4.0655e-12 7884000.0 23464.0 18723.0 22053.0 24890.0 23684.0 18614.0 20090.0 18534.0 16908.0 20356.0 True False 22159.96481383416 20158.993896066295 20634.133989490932 21499.939062355115 20708.604182353585 21177.909538931664 21024.224807579787 18587.930871531116 20290.072448992232 19768.269388760313 1.120986586030323 1.0197652358748277 1.0438007285161202 1.0875984457485885 1.047567886449783 1.071308222406805 1.06353390851369 0.9402912569625187 1.0263959909676565 1.0 14.27089895554633 -7.736384995428987 24.996594681833336 0.9875077287887045 1.062835547861333 0.5375401082936792 0.03227266208830934 156.8807182261703 156519.02699513535 0.014346787418505999 0.008278929991602858 1.8349110015539203e-08 7.736384995428987 0.07532781907262842 GAT(ph)PPAPPR ddPTM_A459_Selumetinib_30min_R2 1 GATPPAPPR 9 0 Q6SPF0 Q6SPF0 SAMD1 Atherin 1 GAT(1)PPAPPR 106.88 0.030195 3113100.0 25946.0 31672.0 44298.0 51529.0 49492.0 34840.0 35247.0 39636.0 42515.0 42489.0 True False 24504.02519006738 34101.140558468825 41447.91490801566 44510.66130751693 43274.37249590625 39638.89375396902 36886.05534060551 39751.334197906974 51019.18796835255 41262.23217032016 0.5938608723086259 0.8264492434075756 1.0045000652637754 1.0787264519231066 1.0487646988481012 0.9606580077963208 0.8939423148110144 0.9633830286694967 1.2364621418869952 1.0 15.332534248615438 -4.9039826950078265 2.015192004101081 1.0193896875047275 0.5295447387309715 0.7105022691981626 0.08646569949645057 0.3154157771310813 1.738626642129942 0.024469705259555476 0.2637681920543735 1.2474332187474118e-05 4.9039826950078265 -0.48984494877375595 GATQQILDEAER ddPTM_A459_Selumetinib_30min_R2 1 GATQQILDEAER 12 0 F8VQ14;F5GWF6;P78371-2;P78371 F8VQ14 CCT2 T-complex protein 1 subunit beta 0 140.91 0.01435 4527700.0 18609.0 15170.0 18497.0 13536.0 18829.0 15127.0 15082.0 17508.0 16136.0 13302.0 False True 17574.786277729276 16333.490220761938 17306.923158010868 11692.373449097578 16463.53268660426 17210.606940766065 15783.342884416032 17558.945381394573 19363.650877509997 12917.936697253375 1.3604948444642901 1.2644039527020428 1.3397590933922663 0.9051270123953791 1.2744707666902217 1.332303087104104 1.2218160883054878 1.3592685730630631 1.4989739717200439 1.0 13.657088035157596 -7.752664442050053 24.784667290034843 1.3218409550955037 1.2388918579987596 0.00011191044976399667 0.1684200005541182 599.4373499155392 1693115.5449585577 0.07987915531748141 0.04520803440796764 1.76740287839201e-08 7.752664442050053 -0.08294909709674414 GATVYS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 GATVYSPSR 9 0 E7EWN3;Q9C0A6;Q9C0A6-2;Q9C0A6-3;H0Y3R4 E7EWN3 SETD5 SET domain-containing protein 5 1 GATVYS(0.975)PS(0.025)R 107.45 0.0092835 0.0 2198.7 3220.0 2973.4 3530.3 3436.4 2495.2 2919.3 2723.5 1749.5 2264.4 True False 2249.92543207455 2843.0009030626125 2569.6286117170866 2913.7993769384166 3125.5782267456966 2470.1005534603323 2699.0948506580858 2651.2639328252194 2968.7737215755997 2555.0577971238254 0.88057711829738 1.112695339519489 1.0057027338519164 1.1404044872168524 1.2232906160729882 0.9667493847852962 1.0563733054087465 1.037653213093532 1.1619203780507374 1.0 11.319140210925108 -4.755572317846499 24.923059095086845 1.0795169450461826 0.880576782841362 0.3733284887592623 0.0768410753869156 202.3620606175814 859537.1851306502 0.01906096967029357 0.1663767506458009 1.755608529444957e-05 4.755572317846499 -0.19894016220482058 GAVAAEGAS(ph)DTER ddPTM_A459_Selumetinib_30min_R1 2 GAVAAEGASDTER 13 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.996)DT(0.004)ER;GAVAAEGAS(0.912)DT(0.088)ER 195.72 0.00020239 13622700.0 3826.51 4556.77 2567.62 2688.68 3403.74 3005.63 4224.6 3682.6099999999997 2040.18 3965.16 True False 3915.6602379076644 4023.2612500151013 2218.9513069270965 2219.1525107743764 3095.872317979106 2975.3960910936908 3905.9350207550256 3584.9352199968685 3462.0364511483867 4474.126909929123 0.8751786251788942 0.8992282362591355 0.49595180279815715 0.4959967733256657 0.6919500452945688 0.6650227297957504 0.873004968206613 0.8012591712678215 0.7737903999695062 1.0 12.127390464109773 -7.258631930182771 24.097244538817353 0.845451904624918 0.679686879360163 0.2787408906882459 0.13638700334017248 239.3978833756269 2054846.9138000805 0.05895837623777703 0.043565005250529754 5.5127471045080955e-08 7.258631930182771 -0.165765025264755 GAVAAEGAS(ph)DTER ddPTM_A459_Selumetinib_30min_R2 2 GAVAAEGASDTER 13 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.92)DT(0.08)ER;GAVAAEGAS(0.937)DT(0.063)ER 165.51 0.00035639 23763300.0 95382.0 67538.0 106913.0 114673.0 136120.0 105133.0 109532.0 114225.0 133802.0 90944.0 True False 90081.05028439868 72717.94743110223 100034.33397807303 99054.33957804106 119019.38867176023 119614.11644764712 114625.45503354039 114557.37583903332 160566.13874024485 88318.21041911063 1.019960094944435 0.8233630084443745 1.1326580724786428 1.1215618965554504 1.3476200220425476 1.3543539421827386 1.2978688595431198 1.297098019710836 1.8180411262669893 1.0 16.43042331881191 -5.890332697284487 1.1362879027497692 1.3784697456314186 0.9141113640057782 0.41806151627321975 0.1970216754085976 0.47852048845716544 1.2378402967358844 0.07191792875761122 0.16521969844418632 1.2872630482467832e-06 5.890332697284487 -0.46435838162564036 GAVAAEGAS(ph)DTEREEPTESQGLAAR ddPTM_A459_Selumetinib_30min_R1 5 GAVAAEGASDTEREEPTESQGLAAR 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.824)DT(0.176)EREEPTESQGLAAR;GAVAAEGAS(0.657)DT(0.343)EREEPTESQGLAAR;GAVAAEGAS(0.838)DT(0.162)EREEPTESQGLAAR;GAVAAEGAS(0.806)DT(0.194)EREEPTESQGLAAR;GAVAAEGAS(0.825)DT(0.164)EREEPT(0.006)ES(0.006)QGLAAR 116.83 4.2802e-08 397402700.0 4513.6 4619.62 4406.27 4776.3 4635.01 4046.04 4573.68 4577.13 2408.55 4079.3299999999995 True False 4618.758098063258 4078.7527427969244 3807.922735908606 3942.2088672551804 4215.774163877479 4005.340511110389 4228.683635309107 4455.72964378641 4087.1334364680833 4602.9517415390965 1.0034339609476064 0.8861167728500028 0.8272784399506532 0.8564523567950807 0.9158849365793793 0.8701678262156006 0.9186895437437619 0.9680157199077086 0.8879374944525188 1.0 12.168343601738943 -7.5152565640034314 5.689602038481745 0.9458766504767525 0.8895016980449997 0.20694904287902027 0.05080291824109299 0.27383061085644356 32.38920091314255 0.023465767061680364 0.014382968490922956 3.053116919620453e-08 7.5152565640034314 -0.056374952431752834 GAVAAEGAS(ph)DTEREEPTESQGLAAR ddPTM_A459_Selumetinib_30min_R2 1 GAVAAEGASDTEREEPTESQGLAAR 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.5)DT(0.5)EREEPTESQGLAAR 109.28 1.2215e-07 205660000.0 37276.0 34353.0 36269.0 34030.0 37440.0 34409.0 28063.0 36156.0 39335.0 41263.0 True False 35204.34914765098 36987.7646376951 33935.4920267014 29395.055294975667 32736.452482153258 39148.52741619748 29367.985105779557 36261.207974052 47203.099111728734 40071.62997585072 0.878535491789752 0.9230411805056564 0.846870767352182 0.7335627553131898 0.816948362267319 0.9769636882699917 0.7328872103150846 0.9049097327936226 1.1779680322506425 1.0 15.290293574375543 -8.103456716803217 5.461035682535172 1.0839856966589263 0.845248393520703 0.5823358119523805 0.0816314753576009 0.15698070613041162 6.672928649066637 0.056766205235512714 0.020791147027000124 7.880309652599237e-09 8.103456716803217 -0.23873730313822328 GAVAAEGASDT(ph)EREEPTESQGLAAR ddPTM_A459_Selumetinib_30min_R1 1 GAVAAEGASDTEREEPTESQGLAAR 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.456)DT(0.542)EREEPT(0.001)ES(0.001)QGLAAR 100.59 4.8971e-06 130730000.0 1182.7 1460.8 1308.3 1371.3 1515.5 1211.8 1407.1 1235.7 654.24 1050.4 True False 1210.2546088664076 1289.7688568925048 1130.6400459774893 1131.8281974890663 1378.423292583256 1199.6103922263667 1300.9613141372913 1202.9252218807128 1110.197496200983 1185.2290717624392 1.0211145150757697 1.0882021776386355 0.953942214981467 0.9549446806987567 1.1630015879829343 1.0121337898357003 1.0976454637606534 1.0149305737936039 0.9366944522801116 1.0 10.210950203496393 -8.009296242814477 23.930051454440953 0.9708356248969517 1.041348348936927 0.17933921049884516 0.062087568844757864 425.96433160979586 1096491.979050863 0.03720343098567704 0.01629807008884521 9.788220793226678e-09 8.009296242814477 0.07051272403997533 GAVAAEGASDT(ph)EREEPTESQGLAAR ddPTM_A459_Selumetinib_30min_R2 2 GAVAAEGASDTEREEPTESQGLAAR 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.035)DT(0.953)EREEPT(0.006)ES(0.006)QGLAAR;GAVAAEGAS(0.019)DT(0.976)EREEPT(0.002)ES(0.002)QGLAAR 97.784 8.0552e-06 331470000.0 56305.0 51469.0 57106.0 61785.0 60246.0 47704.0 43785.0 52626.0 33924.0 49273.0 True False 53175.79350677344 55416.506801080825 53431.86213231165 53369.776414930115 52677.35887392645 54274.79298620377 45821.089258331536 52779.13294729667 40709.74791575661 47850.360463371355 1.111293478081082 1.158120989360179 1.1166449241947267 1.1153474268137182 1.100876949803755 1.1342609012893479 0.9575913078733609 1.1030038736635683 0.8507720218099347 1.0 15.5462421723226 -7.470617600994989 1.0834334021638399 0.9552305667370642 1.128304131393421 0.5565741968966793 0.06146534084370295 0.3767579652974333 0.8271199286160439 0.044161267143290536 0.02123729748012207 3.383626354944912e-08 7.470617600994989 0.17307356465635682 GAVAAEGASDTEREEPT(ph)ESQGLAAR ddPTM_A459_Selumetinib_30min_R2 1 GAVAAEGASDTEREEPTESQGLAAR 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GAVAAEGAS(0.064)DT(0.098)EREEPT(0.419)ES(0.419)QGLAAR 99.881 5.693e-06 102120000.0 32988.0 24306.0 30861.0 34533.0 33047.0 25931.0 27410.0 25725.0 20532.0 31882.0 True False 31154.65902142694 26170.192043891842 28875.436858916237 29829.545827252263 28895.340416071547 29502.759871818907 28684.61931188462 25799.85549099698 24638.97371201258 30961.483820615867 1.0062392100433653 0.8452499303817694 0.9326244512767626 0.9634404474952878 0.9332673002200054 0.9528858514259688 0.9264613891917162 0.8332887286822478 0.7957943441847121 1.0 14.918186993452542 -7.679357444569072 6.743304950552648 0.8612421159708354 0.9354360736407354 0.1553614188229565 0.06213215443721873 0.3100591680496687 20.72960575211621 0.028343258703639553 0.016132861005637204 2.0923896129346503e-08 7.679357444569072 0.0741939576699 GAVY(ph)QAPSPPPAPVGLGSMAVFR ddPTM_A459_Selumetinib_30min_R2 1 GAVYQAPSPPPAPVGLGSMAVFR 23 0 Q13057-2;K7EPT0;K7ESK6 Q13057-2 COASY Bifunctional coenzyme A synthase;Phosphopantetheine adenylyltransferase;Dephospho-CoA kinase 1 GAVY(0.991)QAPS(0.009)PPPAPVGLGSMAVFR 115.04 0.00015206 3147400.0 18681.0 16388.0 17973.0 18213.0 22759.0 17278.0 17758.0 17937.0 14645.0 19044.0 True False 17642.784805968124 17644.906904274645 16816.636747522814 15732.357980822559 19899.810951958498 19657.887665932165 18583.782186809443 17989.193700369786 17574.40921548921 18494.150237745704 0.9539656907274398 0.9540804350265419 0.9092949138696212 0.8506667123701388 1.0760056934837647 1.0629246228254017 1.0048465027001243 0.9726964185494003 0.9502685438134192 1.0 14.174781393125471 -6.263108877186382 24.999940439510752 1.0120346424385882 0.9190999019204735 0.5218572365321829 0.04411308373613005 139.39070726659696 2087304.9958963392 0.014932179813438572 0.017828788210226324 5.456210572977162e-07 6.263108877186382 -0.09293474051811468 GAVYQAPS(ph)PPPAPVGLGSMAVFR ddPTM_A459_Selumetinib_30min_R2 1 GAVYQAPSPPPAPVGLGSMAVFR 23 0 Q13057-2;K7EPT0;K7ESK6 Q13057-2 COASY Bifunctional coenzyme A synthase;Phosphopantetheine adenylyltransferase;Dephospho-CoA kinase 1 GAVY(0.045)QAPS(0.88)PPPAPVGLGS(0.076)MAVFR 101.72 3.9499e-05 4071000.0 16523.0 18703.0 22645.0 26721.0 26474.0 20648.0 19676.0 24379.0 20301.0 20033.0 True False 15604.717806809664 20137.45996037642 21188.045354011778 23081.553703703936 23148.09943943711 23492.074576118037 20590.972987254347 24449.938853839274 24361.76725733331 19454.595238015096 0.8021096103977219 1.035100433291307 1.0891023480462574 1.1864319674254447 1.1898525338735781 1.2075334535983322 1.0584117909078221 1.2567693418808872 1.2522371686114238 1.0 14.24782334422501 -4.34946327941301 1.039497455200223 1.1738510455615303 0.24315566015764892 0.661273497089492 0.07787914825532304 2.246390884755188 1.0725466470747222 0.023927823981992204 2.8757287098635147 4.472359650089751e-05 4.34946327941301 -0.9306953854038814 GCALQCAILS(ph)PAFK ddPTM_A459_Selumetinib_30min_R1 2 GCALQCAILSPAFK 14 0 A0A087WYC1;P34932;A0A087WTS8;D6RJ96;E9PDE8;O95757;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 A0A087WYC1;D6RJ96;Q92598-2 HSPA4;HSPA4L;HSPH1 Heat shock 70 kDa protein 4;Heat shock 70 kDa protein 4L;Heat shock protein 105 kDa 1 GCALQCAILS(1)PAFK;GCALQCAILS(1)PAFK 185.12 7.8962e-05 32910000.0 4698.1 5555.3 6578.5 6589.8 5465.9 4869.5 5147.2 4779.4 3112.96 4313.9 True False 4807.556589088752 4904.882893411094 5685.175833113894 5439.0151358663 4971.510310083023 4820.517251152249 4758.942559965504 4652.634786320854 5282.465758397239 4867.631085944388 0.9876583710238219 1.0076529644110197 1.167955363242342 1.1173844196146707 1.0213408169815072 0.990320993115484 0.9776711661052684 0.9558314309717615 1.0852231126657716 1.0 12.249004116097725 -6.471692397326714 6.526782047553121 0.998309499410875 1.072640606453025 0.2429886706089801 0.056911774210975805 0.333193368866173 33.47474369560634 0.01913825552848628 0.021438080170475438 3.37526287584628e-07 6.471692397326714 0.07433110704214996 GCALQCAILS(ph)PAFK ddPTM_A459_Selumetinib_30min_R2 2 GCALQCAILSPAFK 14 0 A0A087WYC1;P34932;A0A087WTS8;D6RJ96;E9PDE8;O95757;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 A0A087WYC1;D6RJ96;Q92598-2 HSPA4;HSPA4L;HSPH1 Heat shock 70 kDa protein 4;Heat shock 70 kDa protein 4L;Heat shock protein 105 kDa 1 GCALQCAILS(1)PAFK;GCALQCAILS(1)PAFK 109.44 0.0045667 12673200.0 58398.0 64501.0 69232.0 76985.0 63822.0 56223.0 56818.0 55636.0 48457.0 66958.0 True False 55152.472945716305 69448.01929659628 64777.68849410227 66499.51019346746 55804.109784080785 63967.2079084214 59460.149582731094 55797.89154896435 58149.75400170432 65024.748562223176 0.8481766429737142 1.0680244188893773 0.9962005225151391 1.0226800051342462 0.8581980094960456 0.9837363361306996 0.9144233679863101 0.8581023807507766 0.8942711088849491 1.0 15.988701295113563 -6.250136926096959 24.843572796413646 0.9141227833518702 0.9906764075390136 0.17868504269428742 0.06798870239301508 1040.300365998834 2286651.4635373424 0.01950828777483882 0.02494558605235058 5.621640559203204e-07 6.250136926096959 0.0765536241871434 GCDS(ph)PDPDTSYVLTPHTEEK ddPTM_A459_Selumetinib_30min_R1 3 GCDSPDPDTSYVLTPHTEEK 20 0 Q02078-3;Q02078-5;Q02078 Q02078-3 MEF2A Myocyte-specific enhancer factor 2A 1 GCDS(1)PDPDTSYVLTPHTEEK;GCDS(1)PDPDTSYVLTPHTEEK;GCDS(0.978)PDPDT(0.019)S(0.004)YVLTPHTEEK 170.37 1.2598e-09 31384100.0 11823.2 13055.0 13905.2 14671.7 13003.7 12056.400000000001 11925.0 10940.0 6097.2 10419.6 True False 12098.657556057578 11526.514530895158 12016.950215796203 12109.5630169185 11827.517630989709 11935.123562335337 11025.487649127419 10649.835661871815 10346.503078131313 11757.057155498778 1.0290549238674946 0.9803911283619307 1.0221052816925256 1.029982491090881 1.0059930367403187 1.0151454912978182 0.93777613762563 0.9058249459041615 0.8800249026000737 1.0 13.521239371826319 -7.326066890290168 3.813163229982102 0.9201204126400903 1.0133761939877461 0.6193104561851634 0.031620494523544644 0.1419128384183164 4.115165030119786 0.013360115827129792 0.008855484101468417 4.7199033943674786e-08 7.326066890290168 0.09325578134765589 GCDS(ph)PDPDTSYVLTPHTEEK ddPTM_A459_Selumetinib_30min_R2 2 GCDSPDPDTSYVLTPHTEEK 20 0 Q02078-3;Q02078-5;Q02078 Q02078-3 MEF2A Myocyte-specific enhancer factor 2A 1 GCDS(1)PDPDTSYVLTPHTEEK;GCDS(1)PDPDTSYVLTPHTEEK 122.47 0.00016017 56507000.0 384190.0 348370.0 392160.0 397890.0 428400.0 314700.0 269791.0 309290.0 254930.0 398880.0 True False 362838.25783442514 375088.85881389864 366928.85255152336 343696.69560146466 374580.56205540744 358047.0684378314 282336.8160807246 310189.9826942844 305923.123339342 387363.29798529693 0.9366872383665974 0.9683128493710207 0.9472473372153363 0.8872722258124472 0.9670006528848413 0.9243185152028052 0.728868267977833 0.800772774053721 0.7897576381925421 1.0 18.563327741947994 -7.118137224441681 7.342218353851497 0.8136214483921446 0.9406277477550383 0.36870611001128195 0.06859105682491261 0.2398566229511678 13.608301157965034 0.024741366938640166 0.019156366234554793 7.61838253231816e-08 7.118137224441681 0.12700629936289376 GCEIS(ph)PALFEAPRGYS(ph)MMGGQREAAT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GCEISPALFEAPRGYSMMGGQREAATR 27 2 K7EKP0;Q86YJ7-2;Q86YJ7 K7EKP0 ANKRD13B Ankyrin repeat domain-containing protein 13B 3 GCEIS(1)PALFEAPRGY(0.476)S(0.525)MMGGQREAAT(0.999)R 46.403 0.018068 248480000.0 0.0 0.0 0.0 64.165 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 52.95978727622401 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GCGFPVGEHS(ph)PHSR ddPTM_A459_Selumetinib_30min_R1 2 GCGFPVGEHSPHSR 14 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 GCGFPVGEHS(0.984)PHS(0.016)R;GCGFPVGEHS(0.994)PHS(0.006)R 113.01 0.0022688 17480200.0 5462.299999999999 6570.799999999999 7003.1 7664.2 7352.9 6028.0 6591.4 5549.5 3296.4 5039.1 True False 5589.560962214402 5801.487681317956 6052.117485274746 6325.791344852114 6687.831493259931 5967.363792986084 6094.205391233412 5402.309232683512 5593.7500404697375 5685.91756999058 0.9830534638270639 1.0203256747754026 1.0644047175810136 1.1125365900903474 1.1762097165385061 1.0494988222272048 1.071806848449178 0.950120920007017 0.9837902100432675 1.0 12.473177468758811 -7.75225961919724 24.844619917523374 0.9752166745477049 1.0714032085739398 0.405772624780775 0.04993737492727972 181.58497474594196 491455.34984678944 0.026495802392446997 0.01501824402360875 1.769051111732657e-08 7.75225961919724 0.0961865340262349 GCGFPVGEHS(ph)PHSR ddPTM_A459_Selumetinib_30min_R2 1 GCGFPVGEHSPHSR 14 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 GCGFPVGEHS(0.917)PHS(0.083)R 81.71300000000002 0.020733 5536600.0 43341.0 43162.0 51678.0 58375.0 68373.0 46366.0 37823.0 49642.0 44285.0 50209.0 True False 40932.28072776964 46472.38661229577 48353.09374275208 50424.22429750818 59783.37247762454 52752.495631358455 39581.84444485267 49786.45000132448 53143.23742628469 48759.33571135129 0.8394757666528363 0.9530972055773288 0.9916684269243512 1.0341450219095027 1.226090790726397 1.0818952896250706 0.8117798133914675 1.0210649770959468 1.0899089712970151 1.0 15.573390850616937 -4.862350082117261 1.5351874446635407 1.0363790878075423 0.7871410692326986 0.2819061214587203 0.09689352411090497 1.3672871551891048 3.4492152891484764 0.030316330379582538 0.49689193586288116 1.3729348145044511e-05 4.862350082117261 -0.24923801857484373 GCGFPVGEHSPHS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GCGFPVGEHSPHSR 14 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 GCGFPVGEHS(0.376)PHS(0.624)R 96.773 0.0076479 5570900.0 46967.0 39922.0 49472.0 53278.0 53278.0 44210.0 41621.0 40081.0 40661.0 47115.0 True False 44356.76216379769 42983.889030537764 46289.02538104093 46021.44449032362 46584.74132863678 50299.52620157784 43556.45897044687 40197.62907423324 48794.33616326435 45754.6675305287 0.9694478084493066 0.9394427137265897 1.011678761519919 1.005830595525952 1.0181418386999366 1.0993310391342412 0.9519566269689288 0.8785470694855851 1.0664340666601393 1.0 15.481631302829616 -5.265252595440635 24.601379490361236 1.0017702563827138 0.9544452608470689 0.10773586641393296 0.05674579033470037 610.7692451274512 3940488.8586296462 0.01550181045350975 0.03448416736869246 5.429344567474221e-06 5.265252595440635 -0.04732499553564484 GCHLLVAT(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 GCHLLVATPGR 11 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;O15523;O15523-2;A0A2R8YDH3;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 GCHLLVAT(1)PGR 91.307 0.036066 5271900.0 31909.0 25896.0 36742.0 40021.0 38975.0 28268.0 32047.0 26135.0 24093.0 30588.0 True False 30135.625521847684 27882.13993123604 34378.05972166487 34570.07075992421 34078.61205907914 32161.660408645148 33537.2489999258 26211.048523117843 28912.27321466586 29704.844962831612 1.0145020302093846 0.9386394699626864 1.157321634389294 1.1637855980457141 1.1472408659839912 1.0827075666911457 1.1290161265574525 0.8823829431163366 0.9733184351186662 1.0 14.85841063831249 -7.755089289360471 24.993623401915226 0.9458880097574639 1.0918975084473548 0.43995621533887874 0.07152964030941407 141.87194579056919 558407.2632889895 0.037850031706714804 0.02116823013654791 1.757562228430457e-08 7.755089289360471 0.14600949868989088 GCLTTPNSPS(ph)MHSR ddPTM_A459_Selumetinib_30min_R2 1 GCLTTPNSPSMHSR 14 0 O75128-3;O75128;O75128-7;A0A0J9YWK3;A0A3B3IU00;O75128-5;O75128-4 O75128-3 COBL Protein cordon-bleu 1 GCLT(0.133)T(0.043)PNS(0.263)PS(0.555)MHS(0.006)R 125.36 0.0017937 0.0 5581.8 6079.3 4776.7 7167.5 7152.6 4664.1 4499.5 6303.1 5682.4 5904.3 True False 5271.585901715799 6545.5627619695415 4469.372322477727 6191.27413537285 6254.026442944699 5306.537438515701 4708.735665590107 6321.440977465624 6819.03877952174 5733.827517786284 0.9193834110571664 1.1415695260565932 0.7794744973778461 1.0797803240797827 1.0907245506679024 0.9254790839199238 0.8212203194085711 1.1024818862891441 1.1892647203581097 1.0 12.485282791441943 -7.953979771102601 24.998414816393982 1.1117134060213336 0.9719150597117637 0.2057997683420234 0.11733945991909077 177.35522397539444 96339.8956325811 0.0632777955902709 0.030397653720198585 1.1117835115702462e-08 7.953979771102601 -0.1397983463095699 GCPS(ph)PSPSEVR ddPTM_A459_Selumetinib_30min_R1 1 GCPSPSPSEVR 11 0 B4E099;Q8NFT6-4;Q8NFT6-2;Q8NFT6 B4E099 DBF4B Protein DBF4 homolog B 1 GCPS(0.505)PS(0.494)PS(0.001)EVR 101.39 0.015317 3372800.0 2304.5 2402.7 2694.4 2730.6 2572.4 2191.5 2730.0 2256.1 1392.1 1906.0 True False 2358.1903662235845 2121.390767015074 2328.515279279787 2253.7519697102357 2339.726874194108 2169.455499722794 2524.0739020643896 2196.2608991543875 2362.2920250388056 2150.6536660121933 1.0964993590047494 0.986393486101656 1.0827011880519983 1.0479381247326587 1.0879142984153742 1.008742380982924 1.1736310415542655 1.0212062192360152 1.098406527453134 1.0 11.07055950140081 GCT(ph)PSGEGADSEPR ddPTM_A459_Selumetinib_30min_R1 2 GCTPSGEGADSEPR 14 0 Q92917 Q92917 GPKOW G patch domain and KOW motifs-containing protein 1 GCT(0.851)PS(0.024)GEGADS(0.125)EPR;GCT(0.984)PS(0.015)GEGADS(0.001)EPR 128.35 0.0026691 3772200.0 1246.86 1225.54 1177.69 1763.91 1546.21 1165.33 1415.62 1137.42 901.51 1146.38 True False 1275.909412032779 1082.0532070619115 1017.7661665881133 1455.8762311915268 1406.355578505548 1153.6078382349822 1308.8386436777996 1107.2519267391438 1529.7966263147293 1293.5290396868104 0.9863786377317842 0.8365124971016488 0.786813542921723 1.1255071873330529 1.0872238158998389 0.8918298722650201 1.0118355317285308 0.8559930954524468 1.1826534846756314 1.0 10.337096727507216 -5.753533817018806 24.999996160903965 1.0130004731151705 0.8665626649499552 0.30780393003481343 0.10395762373343329 228.8401217855061 723660.167496257 0.0282757579944931 0.0478450638561273 1.7638684127573512e-06 5.753533817018806 -0.14643780816521534 GCT(ph)PSGEGADSEPR ddPTM_A459_Selumetinib_30min_R2 2 GCTPSGEGADSEPR 14 0 Q92917 Q92917 GPKOW G patch domain and KOW motifs-containing protein 1 GCT(0.993)PS(0.007)GEGADSEPR;GCT(0.926)PS(0.053)GEGADS(0.021)EPR 155.66 0.00076398 5889900.0 15168.4 15060.8 16060.6 20416.3 19969.2 13013.3 13767.9 15447.800000000001 13589.5 12723.0 True False 14325.401051916222 16215.914931895271 15027.278481459123 17635.564719918053 17460.490569086942 14805.763952024265 14408.134630576296 15492.750540479048 16307.779722355104 12355.653931676043 1.1594207098331204 1.312428708473513 1.216226884028685 1.4273275066976396 1.4131579490360837 1.1982986925578178 1.166116719539897 1.2538996823762172 1.3198637492222929 1.0 13.592883747886724 -6.828725678380414 24.998659563446022 1.2021589193624043 1.3078715469883613 0.22775812279272933 0.1070167569672507 95.47080202568864 35468.39952197298 0.038073040482433713 0.0335772751659518 1.483454811832105e-07 6.828725678380414 0.10571262762595701 GCVPGVY(ph)RVQT(ph)VPSARR ddPTM_A459_Selumetinib_30min_R1 1 GCVPGVYRVQTVPSARR 17 2 F5H0R1;Q9H6E5;H3BRB1 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 2 GCVPGVY(0.998)RVQT(0.999)VPS(0.003)ARR 81.44800000000002 0.045711 0.0 518.3 364.8 618.98 677.58 302.58 275.83 712.2 970.36 829.9 325.94 True False 530.3753815637599 322.0890464090811 534.9259158137631 559.2533727518718 275.21169242483774 273.0554006336017 658.4781806044904 944.6229006265023 1408.2796865021944 367.77757392445676 1.4421090875777582 0.875771306477865 1.45448214828792 1.5206293488323055 0.7483101524873497 0.7424471201979503 1.79042504842817 2.568462482762835 3.8291613908776876 1.0 8.522689700589334 -7.595422153436679 3.325678702313458 2.6484749089727657 1.1380047535732996 0.4180443309834705 0.6967109302119346 0.20663776087595168 4.597304259785755 0.34936603950369655 0.1888868966821004 2.5385039677979717e-08 7.595422153436679 -1.5104701553994662 GDAAS(ph)SPAPAASVGSSQGGAR ddPTM_A459_Selumetinib_30min_R1 2 GDAASSPAPAASVGSSQGGAR 21 0 E7EXA6;A0A0D9SF58;Q8WVB6;Q8WVB6-2;F8WCC1 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 GDAAS(0.899)S(0.101)PAPAASVGSSQGGAR;GDAAS(0.926)S(0.074)PAPAASVGSSQGGAR 340.8 5.509099999999996e-175 54997800.0 6525.900000000001 6781.799999999999 7236.0 8148.6 7555.8 6426.700000000001 6901.3 5901.63 3404.0200000000004 5727.65 True False 6677.940772809066 5987.783703226712 6253.39094450287 6725.599978166271 6872.37922408484 6362.053232976724 6380.729384731495 5745.099601204071 5776.373320215932 6462.849669535539 1.03328115525995 0.9264928026179868 0.9675903454756172 1.0406554882236052 1.0633667152246684 0.9844037163615382 0.9872934867739318 0.88894216869769 0.8937811670669819 1.0 12.65795471855893 -7.653159749374345 5.778735984771449 0.9190274433607974 1.0007079807806927 0.3386260213873412 0.04647820147564288 0.22812341032185623 10.717944686184508 0.023435605853526182 0.013243172416509607 2.222492226453196e-08 7.653159749374345 0.08168053741989523 GDAAS(ph)SPAPAASVGSSQGGAR ddPTM_A459_Selumetinib_30min_R2 3 GDAASSPAPAASVGSSQGGAR 21 0 E7EXA6;A0A0D9SF58;Q8WVB6;Q8WVB6-2;F8WCC1 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 GDAAS(0.5)S(0.5)PAPAASVGSSQGGAR;GDAAS(0.902)S(0.098)PAPAASVGSSQGGAR;GDAAS(0.908)S(0.092)PAPAASVGSSQGGAR 243.61 1.9793e-31 49362200.0 22905.4 25306.199999999997 29578.5 31462.6 34581.0 23768.699999999997 22766.0 27024.199999999997 22549.4 24306.4 True False 21632.409565581205 27247.104167741945 27675.451512635784 27177.339603987708 30236.625621937565 27042.622674223974 23824.66410997319 27102.83594790286 27059.91008287825 23604.611076388486 0.9164484640553956 1.1543127772605843 1.1724595428864883 1.1513572291463423 1.2809626697125729 1.1456499997695155 1.0093224596191217 1.1482009112623601 1.1463823739907357 1.0 14.526781091985612 -10.374169682105602 13.674825609397598 0.9999998895317939 1.1305163197872452 0.13724503862474957 0.09311307984517106 0.0 0.0 0.09172096964483284 0.022245602701748062 4.225035067300039e-11 10.374169682105602 0.13051643025545134 GDAASS(ph)PAPAASVGSSQGGAR ddPTM_A459_Selumetinib_30min_R1 2 GDAASSPAPAASVGSSQGGAR 21 0 E7EXA6;A0A0D9SF58;Q8WVB6;Q8WVB6-2;F8WCC1 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 GDAAS(0.081)S(0.919)PAPAASVGSSQGGAR;GDAAS(0.072)S(0.928)PAPAASVGSSQGGAR 349.02 2.103699999999998e-195 53009200.0 4370.5 5163.3 4806.5 6041.1 5051.3 3838.8 4617.0 3959.3999999999996 2137.6800000000003 3649.9 True False 4472.3241464873845 4558.778435646955 4153.803700214632 4986.13529049165 4594.41080687945 3800.1851573515255 4268.7359728319725 3854.383850056239 3627.4868300301373 4118.400218036678 1.0859372352644807 1.106929437231871 1.0085964161576388 1.2106971218228613 1.1155814305657006 0.9227333324013731 1.0365034350321016 0.9358934649371449 0.8807999800853331 1.0 12.00786831971262 -6.755818653655563 24.999432104341217 0.9562617151676921 1.1060804615427584 0.6073948661646558 0.060439886103564565 98.20965646086178 436809.1126379974 0.020565982148902096 0.020015257655931828 1.7546130145617562e-07 6.755818653655563 0.14981874637506631 GDAASS(ph)PAPAASVGSSQGGAR ddPTM_A459_Selumetinib_30min_R2 1 GDAASSPAPAASVGSSQGGAR 21 0 E7EXA6;A0A0D9SF58;Q8WVB6;Q8WVB6-2;F8WCC1 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 GDAAS(0.226)S(0.774)PAPAASVGSSQGGAR 316.25 6.691699999999996e-119 46298000.0 18066.0 15432.0 20404.0 21869.0 22209.0 17456.0 15727.0 16858.0 14777.0 16992.0 True False 17061.964043928052 16615.584778299148 19091.22885419547 18890.404473870778 19418.906869020888 19860.405550209045 16458.336662459285 16907.05398900786 17732.81290387736 16501.39680948198 1.0339708959743312 1.0069198971538915 1.1569462315593386 1.1447760872592334 1.1768038241382366 1.2035590550005393 0.9973905150261007 1.0245832025136674 1.074624961063162 1.0 14.010300530373286 -7.284258516300599 24.801608440098118 1.026198264402441 1.1206533731677857 0.38053698589517837 0.06019838400709644 927.5531750647663 1008132.4488015354 0.028249661746529955 0.019060409332430032 5.196865580176433e-08 7.284258516300599 0.09445510876534469 GDALNLSS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 GDALNLSSPKR 11 1 K7EIX9;K7EMC4;A0A0C4DGQ1;Q9BUG6-2;A6NJL1;Q9BUG6 K7EIX9 ZSCAN5A;ZSCAN5B Zinc finger and SCAN domain-containing protein 5A;Zinc finger and SCAN domain-containing protein 5B 1 GDALNLS(0.165)S(0.835)PKR 66.78399999999999 0.039361 9657200.0 48119.0 32382.0 43974.0 50880.0 42840.0 36265.0 46104.0 41426.0 30678.0 38844.0 True False 45444.7386156191 34865.59527545899 41144.76071527112 43950.05622710439 37458.056205540764 41260.174569106995 48247.92735334286 41546.542801556505 36814.45721493874 37722.472791167485 1.204712609038179 0.9242659002890866 1.0907227885894306 1.1650894804911904 0.9929904758076031 1.093782340238518 1.2790234516290737 1.1013737893472457 0.9759290547770942 1.0 15.203136630499461 -5.492944766221216 24.929840501994708 1.097982651043444 1.0502405510914175 0.0 0.10609453658198913 2818.263003599058 2347125.0200022175 0.027619390169058775 0.057355645659128575 3.2140692795076035e-06 5.492944766221216 -0.047742099952026607 GDAVANHVPAGWPDQS(ph)LAESDSEDPSGKPR ddPTM_A459_Selumetinib_30min_R2 1 GDAVANHVPAGWPDQSLAESDSEDPSGKPR 30 1 A0A6I8PL36;A0A6I8PRU0;Q9NYQ6 A0A6I8PL36 CELSR1 Cadherin EGF LAG seven-pass G-type receptor 1 1 GDAVANHVPAGWPDQS(0.511)LAES(0.394)DS(0.09)EDPS(0.004)GKPR 79.558 1.3935999999999997e-05 3660800.0 11068.0 4116.1 7460.9 12292.0 6650.1 4649.2 15061.0 8762.9 8835.2 8103.6 True False 10452.884868714482 4431.791634652484 6980.873816813712 10617.808395117272 5814.654985351696 5289.58509876443 15761.366342805337 8788.398588223814 10602.486876114042 7869.628012318637 1.3282565392356755 0.5631513494303959 0.8870652851553182 1.349213505199585 0.7388729144820808 0.6721518590820856 2.0028095760223295 1.1167489205928145 1.347266587380948 1.0 12.942079727578239 -7.220080500765755 24.999982184995286 1.376436699887686 0.9161108060715536 0.28620028935462427 0.34294784462973155 622.3047618714828 376161.6028289799 0.12768615382409002 0.09890436975815775 6.02447906062727e-08 7.220080500765755 -0.4603258938161324 GDCSTNS(ph)PVGVSK ddPTM_A459_Selumetinib_30min_R1 1 GDCSTNSPVGVSK 13 0 Q96L73-2;Q96L73-3;Q96L73 Q96L73-2 NSD1 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 1 GDCS(0.002)T(0.033)NS(0.964)PVGVSK 98.408 0.01258 4156100.0 1514.7 1830.4 1609.1 1689.6 1703.7 1608.2 1685.7 1642.8 773.24 1630.9 True False 1549.9895629068637 1616.0959170701262 1390.5930581536174 1394.5430777200663 1549.600635812666 1592.022968128769 1558.5462918351436 1599.2276074335473 1312.1318047848624 1840.2419013112744 0.8422748997305247 0.8781975434417444 0.755657751930734 0.7578042195030865 0.842063554094975 0.8651161388045584 0.8469246845887994 0.8690311889398936 0.7130213717283015 1.0 10.845679706859405 -6.497306162597605 23.862200496258975 0.8503008860353528 0.8084703901934057 0.09053734880679132 0.07293700080194343 1266.9999001124631 1182258.8329809138 0.022290729300293723 0.025157414979910035 3.181953563589974e-07 6.497306162597605 -0.04183049584194709 GDDDEES(ph)DEEAVK ddPTM_A459_Selumetinib_30min_R1 1 GDDDEESDEEAVK 13 0 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 GDDDEES(1)DEEAVK 171.99 8.8335e-10 0.0 2326.5 2938.0 1345.5 1695.6 1665.8 1847.0 2201.2 1858.7 1192.6 1868.7 True False 2380.7029234190363 2594.017594160857 1162.788490302462 1399.4952903540152 1515.1286841208762 1828.4208569418226 2035.1617118037116 1809.4012380915128 2023.755095942302 2108.565847679427 1.1290626403909125 1.2302284024071108 0.5514594156887079 0.6637190353311583 0.7185588658700626 0.867139557891485 0.9651876482982498 0.8581193895760199 0.9597779923114741 1.0 11.042046360411083 -5.237967951377896 24.779901270995634 0.8151646400144179 1.179645627961613 0.5178171989238926 0.1374979086723431 582.8025509619678 615289.8370511036 0.03755731287569951 0.09923579896517065 5.781387093923557e-06 5.237967951377896 0.3644809879471951 GDDDEES(ph)DEEAVK ddPTM_A459_Selumetinib_30min_R2 1 GDDDEESDEEAVK 13 0 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 GDDDEES(1)DEEAVK 113.69 0.004481100000000001 13454000.0 86649.0 60311.0 74879.0 75426.0 75672.0 65466.0 104710.0 79459.0 69430.0 67668.0 True False 81833.39546342983 64936.65976956969 70061.3666620908 65152.8486828926 66165.40684373665 74483.3472588214 109579.22247892882 79690.21253485433 83317.9400362864 65714.2490174214 1.2452914959392611 0.9881671135335418 1.06615182718617 0.9914569466603815 1.0068654490169346 1.1334428738442288 1.6675108384770316 1.2126778244658596 1.2678824042286188 1.0 16.003918607903657 -7.0147663986669775 24.855191648663443 1.318417487177792 1.0539941040219118 0.2818007641825647 0.16858180096867367 695.5995654646753 1170850.2952590396 0.06046527442757979 0.048604802994851794 9.665706449230007e-08 7.0147663986669775 -0.2644233831558802 GDDDEES(ph)DEEAVKK ddPTM_A459_Selumetinib_30min_R1 3 GDDDEESDEEAVKK 14 1 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 GDDDEES(1)DEEAVKK;GDDDEES(1)DEEAVKK;GDDDEES(1)DEEAVKK 205.3 2.4724e-05 49203200.0 10807.4 18838.5 10647.4 11176.5 9289.4 13752.1 14158.1 11466.4 6248.599999999999 12955.900000000001 True False 11059.191392460314 16632.879662218955 9201.541561981743 9224.734083888687 8449.175410176778 13613.766359907753 13090.143118248301 11162.273823883632 10603.417820312829 14618.915966152876 0.7564987320582197 1.137764229627491 0.6294270781285042 0.6310135515688496 0.5779618290261141 0.9312432188151063 0.8954250197864099 0.7635500367966821 0.7253217574314597 1.0 13.835548714900067 -10.531539344129843 15.919793952707927 0.999955435716253 0.785617685985536 0.1428439301736022 0.15926739448583915 0.0 0.0 0.1619518813665061 0.03927910077303561 2.940767268141824e-11 10.531539344129843 -0.21433774973071695 GDDDEES(ph)DEEAVKK ddPTM_A459_Selumetinib_30min_R2 4 GDDDEESDEEAVKK 14 1 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 GDDDEES(1)DEEAVKK;GDDDEES(1)DEEAVKK;GDDDEES(1)DEEAVKK;GDDDEES(1)DEEAVKK 206.43 1.3621e-05 67251600.0 326787.0 247248.0 233813.0 243060.0 241243.0 219327.0 297816.0 309489.0 237863.0 222089.0 True False 308625.4867720091 266211.12657237647 218769.7261363459 209954.80869811302 210935.8976002165 249537.30339772583 311665.0341112082 310389.5617513382 285442.24644751893 215676.7135134793 1.430963416236963 1.2343063014808915 1.0143409669615226 0.9734699925543483 0.9780188791083071 1.1569969670468403 1.4450564877127074 1.4391426718950795 1.3234727189483042 1.0 17.71851089241784 -7.116379722093739 6.134530581730305 1.3371709459178638 1.112965332304028 0.177336292403801 0.17302630285454662 0.3420996854731462 16.040412481782955 0.06933531565703967 0.053640257952759236 7.649275058659815e-08 7.116379722093739 -0.22420561361383573 GDDGIFDDNFIEER ddPTM_A459_Selumetinib_30min_R1 1 GDDGIFDDNFIEER 14 0 O60493-4;O60493;O60493-2 O60493-4 SNX3 Sorting nexin-3 0 183.89 0.0010747 3030400.0 752.22 838.21 723.72 670.36 882.22 722.91 720.61 560.76 465.34 659.87 False True 769.7452624346735 740.0719835267431 625.4427991094002 553.2942102156863 802.4233567685914 715.6381817497631 666.2538075335606 545.8868231948118 789.6479929111117 744.5707421781042 1.0338107836240327 0.9939579164255088 0.8400045337260806 0.7431049581630434 1.0776992853912712 0.9611419589981414 0.8948159923455468 0.7331564245969707 1.060541259788348 1.0 9.540265116541821 GDDGIFDDNFIEER ddPTM_A459_Selumetinib_30min_R2 2 GDDGIFDDNFIEER 14 0 O60493-4;O60493;O60493-2 O60493-4 SNX3 Sorting nexin-3 0 ; 143.76 0.0074152 4172500.0 18966.0 13306.5 21545.9 17918.3 23561.0 17012.1 12655.1 18924.4 14587.699999999999 19178.6 False True 17911.945646913508 14327.065762858843 20159.660251402194 15477.796629208413 20601.056541987527 19355.362354532037 13243.58722560493 18979.466870896922 17505.64761439342 18624.8639860129 0.9617222257496867 0.7692440478286626 1.0824057704014327 0.8310287066167084 1.1061050731677144 1.0392216753404337 0.7110702787172427 1.0190392201065375 0.9399074069770388 1.0 14.184942269423782 -5.251782910051897 24.970802163083707 0.9604571214115357 0.865483162068373 0.09894965462583194 0.12048896041629328 1672.6944107955358 4325420.281255597 0.029998178722259173 0.0771881252650414 5.600374763961425e-06 5.251782910051897 -0.09497395934316277 GDDLLPAGTEDYIHIR ddPTM_A459_Selumetinib_30min_R1 2 GDDLLPAGTEDYIHIR 16 0 K7EM18;P41567;O60739 K7EM18 EIF1;EIF1B Eukaryotic translation initiation factor 1;Eukaryotic translation initiation factor 1b 0 ; 157.37 0.00010787 8455900.0 5620.9 6118.2 4647.1 5045.1 5354.6 5091.5 5895.6 5580.9 2951.2 5718.2 False True 5751.856033632525 5401.878299725984 4016.049344693106 4164.0679932561015 4870.277375431411 5040.284132712119 5450.890145425207 5432.876402681939 5007.9708528801975 6452.186669984745 0.8914584043871323 0.8372166795569099 0.622432293128711 0.6453731434378892 0.7548258636235219 0.781174567710397 0.8448128400845065 0.8420209582520934 0.7761664547272061 1.0 12.655572462765923 -7.157017673765746 2.020810685777114 0.8572700362288768 0.7423646204005596 0.26473757177419044 0.09071598355532866 0.5438122803336736 4.357754570154797 0.046460678605638066 0.032150044257892044 6.965981652281131e-08 7.157017673765746 -0.11490541582831715 GDDWNDREWDR ddPTM_A459_Selumetinib_30min_R1 2 GDDWNDREWDR 11 1 C9JUL9;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 C9JUL9;Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 0 ; 141.89 0.002725 13404700.0 4328.2 4005.7 5566.1 6150.1 5234.6 5174.5 4322.5 4164.8 2680.7 4253.4 False True 4429.0386387888575 3536.710781800592 4810.254192398763 5076.100486675063 4761.13135424369 5122.449228070087 3996.450344935283 4054.3359748230123 4548.952109418526 4799.365321624482 0.9228384050768036 0.736912184172613 1.0022688147379026 1.05766078356313 0.9920335367660967 1.067318048282319 0.8327039258562985 0.8447650268579069 0.9478236817944092 1.0 12.228627918019665 -5.276750637000677 24.945892369240827 0.9652929585553529 0.8298752841346317 0.2977501449702007 0.08480806858450701 924.1247461998898 1505631.616697962 0.023979604890197917 0.05021405886961708 5.287487613449774e-06 5.276750637000677 -0.13541767442072117 GDEASEEGQNGS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 GDEASEEGQNGSSPK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 GDEASEEGQNGS(0.5)S(0.5)PK;GDEASEEGQNGS(0.5)S(0.5)PK 230.86 6.3272e-14 97127800.0 1858.23 2664.45 2196.98 2395.21 1787.85 1986.0700000000002 1957.5900000000001 2030.74 1637.4 2282.83 True False 1901.523143513844 2352.4949553307993 1898.642183147308 1976.931537160205 1626.139283170554 1966.0919390072784 1809.9274102352483 1976.8781784268351 2778.5482090356577 2575.85346714723 0.7382109144662604 0.9132875706381695 0.7370924656091029 0.7674860244863486 0.6313011605320512 0.7632778665724083 0.7026515418362488 0.7674653095139908 1.078690323216605 1.0 11.33083480970121 -8.253949702725802 22.197485490072104 1.0393452054924464 0.7525804535856782 0.7362507793648865 0.0686505350835931 56.29271222633981 166843.6313209734 0.050365378163510444 0.018054105330966876 5.5725028244193254e-09 8.253949702725802 -0.2867647519067682 GDEASEEGQNGSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 GDEASEEGQNGSSPK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 GDEASEEGQNGS(0.087)S(0.913)PK;GDEASEEGQNGS(0.08)S(0.92)PK;GDEASEEGQNGS(0.014)S(0.986)PK;GDEASEEGQNGS(0.201)S(0.798)PK 235.93 2.7916e-15 198586800.0 7974.240000000001 9319.24 8625.72 8324.52 6616.12 8061.250000000001 7546.18 7982.26 5310.17 9283.11 True False 8160.024276830012 8228.139048402858 7454.394601688413 6870.798852593662 6017.693114170861 7980.161144029373 6976.965567135629 7770.54453476535 9010.970650528208 10474.687593648721 0.7790231645455283 0.7855259619763698 0.7116579406347499 0.6559430809907628 0.5744985767231532 0.7618519476292646 0.6660786304849874 0.7418402186502425 0.8602615180611181 1.0 13.354619595902257 -8.467632194140087 1.8934965605634122 0.9985198717213918 0.7029498446661004 0.7068469747311776 0.060533159804306375 0.19140872233883688 1.5119101369464636 0.06241872854028716 0.017711846116220183 3.4069660497008686e-09 8.467632194140087 -0.29557002705529134 GDEASEEGQNGSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 GDEASEEGQNGSSPK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 GDEASEEGQNGS(0.077)S(0.923)PK;GDEASEEGQNGS(0.029)S(0.971)PK;GDEASEEGQNGS(0.032)S(0.968)PK;GDEASEEGQNGS(0.003)S(0.997)PK 212.43 7.5438e-07 300752100.0 115127.0 97121.0 92811.0 86455.0 81761.0 62762.0 96568.0 84530.0 58146.0 77228.0 True False 108728.70222989621 104569.8684067646 86839.64130497642 74679.6798568063 71489.45222738611 71406.89580328939 101058.60334586189 84775.96830530517 69776.8247349836 74998.2269775586 1.4497503022628873 1.394297873709129 1.1578892569148478 0.9957526046469388 0.9532152306584206 0.9521144523144016 1.3474798994395056 1.1303729664258906 0.930379657586607 1.0 16.19456886901238 -5.319400966714718 2.739536480437882 1.0551004307725824 1.4414223398144816 0.6215472444241534 0.11636974259690512 0.1964359025032991 2.8497907238875486 0.03446285375268588 0.09764985819252207 4.792907343440916e-06 5.319400966714718 0.3863219090418992 GDEELDSLIK ddPTM_A459_Selumetinib_30min_R2 2 GDEELDSLIK 10 0 Q71UI9-3;Q71UI9-4;Q71UI9;P0C0S5;C9J386;C9J0D1;A0A494C189;Q71UI9-2 Q71UI9-3 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z;Histone H2A 0 ; 176.38 0.00093771 8365900.0 80705.0 69625.0 71022.0 73515.0 74729.0 61463.0 56983.0 68795.0 55925.0 64336.0 False True 76219.73918771255 74965.01362033952 66452.52184290667 63502.13017955141 65340.87493426361 69928.9703444375 59632.82240967243 68995.18206037472 67111.56267505861 62478.45251499724 1.219936411988067 1.1998538792609343 1.0636070383938447 1.0163844913461717 1.0458145537228098 1.1192493976647686 0.9544542159612268 1.104303632421325 1.0741553283341845 1.0 15.931071100369493 -5.260063394526315 3.96819360680743 1.0479542746497827 1.2154324770182143 0.6702053021437083 0.04585527692010727 0.1173856194163114 4.376678733412228 0.0117682237785803 0.030936208884295584 5.494606625210799e-06 5.260063394526315 0.16747820236843158 GDEGIFEESFIEER ddPTM_A459_Selumetinib_30min_R1 1 GDEGIFEESFIEER 14 0 A0A087X0R6;Q9UMY4-3;Q9UMY4;Q9UMY4-1 A0A087X0R6 SNX12 Sorting nexin-12 0 148.78 0.006270899999999999 1504800.0 494.02 475.44 642.23 445.41 654.89 518.62 463.44 641.27 264.2 584.51 False True 505.5297048044154 419.7752637739407 555.0186935168712 367.6275048812113 595.6553151302201 513.4031536692843 428.4823476823154 624.2614364614752 448.328103595469 659.537552109542 0.7664911621597134 0.6364690872131274 0.8415270544363008 0.557401930648753 0.903140864724088 0.7784289947208549 0.649670888809602 0.9465138633346417 0.6797612996583499 1.0 9.365310994361272 -14.522878745223935 0.17071712872575157 1.9695294915184376 0.6951276292312771 0.2939821914275148 0.1165133697929985 159.68430435875288 1.503765292411213 52.36304257856191 0.38904308241204166 3.0000000003896186e-15 14.522878745223935 -1.2744018622871605 GDEHSLGCS(ph)PSNSSAQPSLPLYR ddPTM_A459_Selumetinib_30min_R2 1 GDEHSLGCSPSNSSAQPSLPLYR 23 0 Q70EL1;Q70EL1-7;Q70EL1-9;Q70EL1-10;Q70EL1-8 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 GDEHS(0.015)LGCS(0.983)PS(0.003)NSSAQPSLPLYR 96.591 0.0006144999999999999 0.0 7178.1 6824.0 8909.5 10382.0 11077.0 9135.6 6974.9 8344.3 7787.5 9276.1 True False 6779.169938211005 7347.378857381638 8336.272469930136 8967.953690051057 9685.408230363562 10393.945975280121 7299.246670502151 8368.580531526773 9345.217600930151 9008.27489079778 0.7525491862083524 0.8156255161448507 0.9254016524790873 0.9955239819792897 1.0751679259097093 1.1538220248915634 0.8102824080067258 0.9289881395688232 1.0374036887436204 1.0 13.137035137117945 -5.289296846070786 1.9368053419272917 0.9986288863485352 0.7556937911191961 0.5084474075615447 0.08501364020607548 0.3471307130119939 2.345379490853533 0.026323026541169227 0.10232071793164851 5.136924159413064e-06 5.289296846070786 -0.2429350952293391 GDFS(ph)YIGNLMTK ddPTM_A459_Selumetinib_30min_R2 2 GDFSYIGNLMTK 12 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 1 GDFS(1)YIGNLMTK;GDFS(1)YIGNLMTK 97.223 0.016399 6307900.0 22681.0 19950.7 23730.2 21997.7 24007.4 19699.3 13214.2 16807.9 16740.7 19436.9 True False 21420.480819236807 21480.85453838861 22203.424767488214 19001.575311850913 20991.375783120904 22412.69976255918 13828.686483440548 16856.80820630237 20089.30777423967 18875.7061938689 1.1348174526150703 1.1380159405832402 1.1762963747920703 1.006668313052197 1.1120842615117206 1.187383376937661 0.7326182311490048 0.8930425189483878 1.0642943669447962 1.0 14.204243000322732 -7.239656183029535 24.999221364553794 0.913575627859997 1.1226755535270792 0.5396523325635773 0.09185174776862964 615.4546326888969 706319.967925061 0.035518446562357905 0.02748843773904275 5.758956749967885e-08 7.239656183029535 0.20909992566708213 GDGEKS(ph)DEENEEKEGSK ddPTM_A459_Selumetinib_30min_R2 1 GDGEKSDEENEEKEGSK 17 2 D6R9U7;O15318 D6R9U7 POLR3G DNA-directed RNA polymerase III subunit RPC7 1 GDGEKS(1)DEENEEKEGSK 79.461 0.019962 7303400.0 23773.0 20138.0 17578.0 16467.0 16182.0 14955.0 23201.0 18365.0 11273.0 17820.0 True False 22451.791830859172 21682.519846124174 16447.05061747933 14224.166192840565 14149.072491084513 17014.915502026593 24279.892471909327 18418.439109510575 13527.91499393716 17305.490298079625 1.2973797011316477 1.2529272197812427 0.950394951786165 0.8219452871796997 0.8176059878901335 0.9832090977459751 1.4030167336318489 1.0643118913281788 0.7817123214034762 1.0 14.078942195978417 -5.231029154224008 6.637925193625984 0.9840911789898535 1.2785431161781367 0.33600104116535 0.1670868445202716 0.2584159828268485 39.7925897781476 0.04752193787310163 0.12373468997243475 5.874499156453183e-06 5.231029154224008 0.2944519371882831 GDGPVQGIINFEQK ddPTM_A459_Selumetinib_30min_R2 1 GDGPVQGIINFEQK 14 0 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 150.22 0.005889899999999999 2437200.0 15868.0 17766.0 17130.0 17128.0 20522.0 13355.0 11529.0 12354.0 13505.0 16804.0 False True 14986.120084636916 19128.595073306285 16027.874449733803 14795.136852551961 17943.84289099223 15194.530025380496 12065.121344280102 12389.9480946852 16206.377361227826 16318.824857964653 0.9183332877871233 1.1721796906209383 0.9821708725497567 0.9066300411534208 1.0995793537323528 0.93110442434613 0.739337633027634 0.7592426662167463 0.9931093385880696 1.0 13.99424955005565 -6.998996166085245 23.679979779782737 0.8503395395364083 1.0164172439107728 0.2712741146909692 0.10836323875441085 19.82647986742284 467666.7115250821 0.037801630861957786 0.03302844796260221 1.0023140863823638e-07 6.998996166085245 0.16607770437436453 GDIFDGTSFSHLPPSSSDGQGVPLS(ph)PVSK ddPTM_A459_Selumetinib_30min_R2 2 GDIFDGTSFSHLPPSSSDGQGVPLSPVSK 29 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 GDIFDGTSFSHLPPSSSDGQGVPLS(0.912)PVS(0.088)K;GDIFDGTSFSHLPPS(0.001)S(0.001)S(0.001)DGQGVPLS(0.921)PVS(0.076)K 103.1 1.9037e-08 9504400.0 50395.2 39643.0 69980.0 85349.0 80087.0 58856.0 54501.0 63402.0 61131.0 66698.0 True False 47594.436531969644 42683.49062766415 65477.56298846301 73724.31896476261 70025.75507313586 66962.87975842717 57035.404491682726 63586.48932323389 73358.9081428523 64772.25543778417 0.7347966534481052 0.6589779889425498 1.01088903799801 1.1382083033310024 1.0811072518602944 1.0338204113140257 0.8805530100224325 0.9816933020699078 1.1325668320028763 1.0 15.983088360658249 -5.278689753334445 9.205198338415542 1.0320141800977791 0.6967509483555183 0.7705707260248709 0.0732209266154903 0.1249658060752405 63.845658980939746 0.020683518953379002 0.04497629153248151 5.263931712534144e-06 5.278689753334445 -0.3352632317422608 GDLAFGAPGPRPPS(ph)PFDDPADDPEHK ddPTM_A459_Selumetinib_30min_R1 2 GDLAFGAPGPRPPSPFDDPADDPEHK 26 1 Q7Z3Z5;Q93074-3;Q93074;Q93074-2 Q7Z3Z5 TNRC11;MED12 Mediator of RNA polymerase II transcription subunit 12 1 GDLAFGAPGPRPPS(1)PFDDPADDPEHK;GDLAFGAPGPRPPS(1)PFDDPADDPEHK 74.278 8.8676e-05 55859000.0 7167.8 12531.5 8571.7 8019.900000000001 7713.2 10233.900000000001 9889.2 9296.0 4784.5 9134.7 True False 7334.795793889094 11064.3061542637 7407.710220977794 6619.375017168062 7015.542421876065 10130.95625763774 9143.249682159403 9049.439882336417 8118.947053945961 10307.2277245129 0.7116167402070009 1.0734512179206341 0.7186908467502466 0.6422071185470855 0.6806430021131221 0.9828982659948466 0.8870716672354783 0.8779703062943703 0.78769454512364 1.0 13.331368731080236 -6.7635824103858315 24.999998438495474 0.8982466369868254 0.7730097799752718 0.24486695399798586 0.12365400736231587 103.84514970989635 1211414.9601062967 0.04508887315397673 0.04171153659446072 1.7235250091874246e-07 6.7635824103858315 -0.12523685701155363 GDLAFGAPGPRPPS(ph)PFDDPADDPEHK ddPTM_A459_Selumetinib_30min_R2 4 GDLAFGAPGPRPPSPFDDPADDPEHK 26 1 Q7Z3Z5;Q93074-3;Q93074;Q93074-2 Q7Z3Z5 TNRC11;MED12 Mediator of RNA polymerase II transcription subunit 12 1 GDLAFGAPGPRPPS(1)PFDDPADDPEHK;GDLAFGAPGPRPPS(1)PFDDPADDPEHK;GDLAFGAPGPRPPS(1)PFDDPADDPEHK;GDLAFGAPGPRPPS(1)PFDDPADDPEHK 94.389 1.9865e-06 32055900.0 107162.0 81188.0 115786.0 115034.0 130446.0 91428.0 107014.0 107738.0 89125.0 99471.0 True False 101206.36504347507 87414.85853943428 108336.45481826474 99366.17075528142 114058.20727796375 104021.37709925024 111990.36304421817 108051.499743014 106952.49036056483 96599.0137733042 1.047695634667485 0.9049249585982002 1.1215068413897644 1.028645809867905 1.1807388380344366 1.0768368437318068 1.1593323644797653 1.1185569657738552 1.10717994090041 1.0 16.559720839504635 -5.277382671416844 24.844045202775316 1.1050894208280904 0.9763102942186221 0.39182746931034274 0.0608257896270155 573.7737360334007 894097.5898375077 0.01478486213130333 0.030938016777848812 5.279798260421724e-06 5.277382671416844 -0.12877912660946822 GDLGIEIPAEK ddPTM_A459_Selumetinib_30min_R1 3 GDLGIEIPAEK 11 0 P14618;P14618-3;B4DNK4;P30613-2;P30613;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 ;; 169.65 0.0056614 51616800.0 11404.8 11297.3 12964.2 13011.7 11447.9 11837.8 11896.7 11466.5 8091.599999999999 9306.0 False True 11670.509650122256 9974.606864027714 11203.732847253199 10739.450854859258 10412.439466290902 11718.722479862416 10999.322340911887 11162.371171558792 13730.854212918612 10500.515748116195 1.1114225177192805 0.9499158996849435 1.0669697675814793 1.0227546067711892 0.9916121946828094 1.1160139902618371 1.0475030564936945 1.0630307538523844 1.3076361716215648 1.0 13.358172569248115 -8.027712980602914 24.64507112729725 1.1643232540420545 1.0420134244718604 0.2104907355943606 0.08359457239768008 775.7994706470549 689910.6745625262 0.051406566144912305 0.019542593106401048 9.381818338740834e-09 8.027712980602914 -0.1223098295701941 GDLGIEIPAEK ddPTM_A459_Selumetinib_30min_R2 1 GDLGIEIPAEK 11 0 P14618;P14618-3;B4DNK4;P30613-2;P30613;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 130.01 0.034302 22532000.0 89690.0 68547.0 89980.0 81265.0 90154.0 62817.0 71638.0 79096.0 65444.0 71925.0 False True 84705.3888575173 73804.33448665586 84190.78476281639 70196.56681005574 78828.0485330141 71469.47155404929 74969.30894800404 79326.15626495231 78534.62865814105 69848.33836640719 1.2127044227333468 1.0566369395861144 1.2053369733890054 1.0049854935964522 1.1285601114732544 1.0232093307522656 1.0733155677194997 1.135691386799022 1.1243592975135317 1.0 16.091938175083143 -2.7006066371255373 1.7087558660876692 1.0867198439497772 160.65215149709204 0.25860720737624987 0.06319961847668965 2523.982931155819 7.116097213225596 0.01680098421731463 1578816.4397157577 0.001992477211138442 2.7006066371255373 159.56543165314227 GDLPSDSGFS(ph)DPESEAK ddPTM_A459_Selumetinib_30min_R2 1 GDLPSDSGFSDPESEAK 17 0 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 GDLPSDSGFS(0.991)DPES(0.009)EAK 185.33 5.794400000000001e-08 2909900.0 24448.0 17178.0 18960.0 22394.0 25473.0 21152.0 22084.0 21649.0 17802.0 21709.0 True False 23089.27803309825 18495.497364024286 17740.134242087155 19343.898568195273 22272.854008490664 24065.49600126158 23110.94975861581 21711.9950058151 21362.897429439327 21082.20476324413 1.095202247221949 0.8773037531762498 0.841474335408044 0.9175462806395127 1.056476505119729 1.1415075544289695 1.0962302101774812 1.0298730730321422 1.0133141988396095 1.0 14.363738130522195 -6.272164869900775 7.649056985294212 1.0641856473327462 0.9222492169775741 0.40056837520832167 0.07308811804783041 0.14348744014184556 61.09395698273826 0.023169603687469117 0.027420216288221114 5.343614628607755e-07 6.272164869900775 -0.14193643035517212 GDLS(ph)DVEEEEEEEMDVDEATGAVK ddPTM_A459_Selumetinib_30min_R1 2 GDLSDVEEEEEEEMDVDEATGAVK 24 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 GDLS(1)DVEEEEEEEMDVDEATGAVK;GDLS(1)DVEEEEEEEMDVDEATGAVK 209.2 6.0802e-32 9983000.0 2486.26 2955.98 3468.0 3026.88 2816.4700000000003 2380.48 2488.7 2324.55 1340.62 2437.57 True False 2544.1850205801916 2609.8924874021795 2997.0646483604137 2498.2922295746425 2561.7207857881644 2356.5345325029066 2300.975355336135 2262.895382797452 2274.934224989243 2750.4558534424673 0.9250048559753804 0.9488945202067655 1.0896610627686647 0.9083193342106484 0.9313804410210467 0.8567796242042827 0.8365796355015978 0.8227346677697861 0.8271117030080443 1.0 11.425455031662505 -6.432594547428738 1.778468544980168 0.8555336459506875 0.9798697542154158 0.3327774116142138 0.06589030947854209 0.35753865855455735 2.257195237781848 0.024052889273131164 0.0280358879942336 3.693222328629497e-07 6.432594547428738 0.1243361082647283 GDLS(ph)DVEEEEEEEMDVDEATGAVKK ddPTM_A459_Selumetinib_30min_R1 3 GDLSDVEEEEEEEMDVDEATGAVKK 25 1 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 GDLS(1)DVEEEEEEEMDVDEATGAVKK;GDLS(1)DVEEEEEEEMDVDEATGAVKK;GDLS(1)DVEEEEEEEMDVDEATGAVKK 202.58 1.4024e-31 30526200.0 4442.01 5047.54 7523.9 7291.700000000001 5844.4 5723.67 5338.900000000001 5360.5 2805.56 4387.87 True False 4545.500190353149 4456.571670262318 6502.19570582437 6018.341477161108 5315.775051912628 5666.095076476552 4936.182474626952 5218.322126642037 4760.830410004935 4951.0958559732035 0.918079617640461 0.9001182364275433 1.3132841485950744 1.2155574548007055 1.073656258442151 1.1444123162432303 0.9969878625298156 1.0539731563359738 0.9615710437642357 1.0 12.273532165612025 -7.275672594882155 23.481354987062502 1.0076307631829915 1.099906371996987 0.12369598243506308 0.1178948619015961 897.2233103121844 1480191.001084216 0.05387572256966137 0.03656947726359283 5.300628961357745e-08 7.275672594882155 0.09227560881399555 GDMEQNDSDNRR ddPTM_A459_Selumetinib_30min_R1 2 GDMEQNDSDNRR 12 1 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 ; 163.46 0.00249 6897500.0 984.79 1011.22 941.4 1098.2 1311.3400000000001 1043.78 794.1400000000001 914.6700000000001 742.59 795.5799999999999 False True 1007.7336909322306 892.8258922965761 813.56305074005 906.4199857671501 1192.7295285358819 1033.2805208764132 734.237380434218 890.4099803331159 1260.1209933722919 897.7004426054464 1.1225723449655751 0.9945699588888219 0.9062745344970538 1.0097131991339967 1.3286498167185437 1.1510304237764049 0.8179091215586345 0.9918787360166929 1.4037210338394976 1.0 9.810090296137737 -6.037616160631952 24.973508275394256 1.1081249357052771 0.9984004607811372 0.0905857948021378 0.16468122922544123 1502.8572406421674 997750.1991029446 0.051018393707139814 0.06588280586938239 9.170306246423311e-07 6.037616160631952 -0.10972447492413995 GDMEQNDSDNRR ddPTM_A459_Selumetinib_30min_R2 3 GDMEQNDSDNRR 12 1 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 ;; 134.49 0.0021546 58277000.0 83555.0 73896.0 61039.0 75637.0 73734.0 59699.3 76863.0 86999.0 71524.6 87066.0 False True 78911.34759716649 79563.58558690993 57111.81719423829 65335.11011889734 64470.875729676474 67922.336678712 80437.28180114499 87252.15268654018 85831.51856430057 84552.17835536499 0.9332858021174735 0.9409998315183736 0.6754623985464053 0.7727194188220665 0.7624981045279678 0.8033185897735325 0.9513330509720818 1.0319326406923244 1.0151307776312828 1.0 16.36755430345731 -7.399623587206179 3.1903839386147395 1.0155702093846155 0.8094994387633738 0.6057157107344733 0.07420968310824516 0.19382047447606915 3.715416606961949 0.03849097457486708 0.02406519492728935 3.984523685646261e-08 7.399623587206179 -0.20607077062124168 GDMS(ph)DEDDENEFFDAPEIITMPENLGHK ddPTM_A459_Selumetinib_30min_R1 3 GDMSDEDDENEFFDAPEIITMPENLGHK 28 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 GDMS(0.902)DEDDENEFFDAPEIIT(0.098)MPENLGHK;GDMS(1)DEDDENEFFDAPEIITMPENLGHK;GDMS(1)DEDDENEFFDAPEIITMPENLGHK 144.36 4.1253e-13 9552400.0 2299.87 3242.69 2666.49 2588.71 2757.81 2679.7200000000003 2932.77 3006.63 1816.5 2884.59 True False 2353.4524962319965 2863.034347314317 2304.3953039811304 2136.6403946050614 2508.3665724309003 2652.7644497910865 2711.548797713326 2926.8844054893643 3082.467828089212 3254.855224785998 0.7230590406326698 0.8796195681798896 0.7079870362383448 0.6564471372902745 0.7706538076807462 0.8150176479709638 0.8330781587656043 0.8992364339897184 0.9470368465595517 1.0 11.668377658735523 -7.775685110641672 0.9251664534739698 0.9933904041725344 0.7485583385324769 0.7274278671015577 0.0546552555461731 0.32473385475409194 0.5077811725261603 0.05243467505532133 0.021857327845467112 1.676157749716381e-08 7.775685110641672 -0.24483206564005755 GDMS(ph)DEDDENEFFDAPEIITMPENLGHK ddPTM_A459_Selumetinib_30min_R2 4 GDMSDEDDENEFFDAPEIITMPENLGHK 28 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 GDMS(1)DEDDENEFFDAPEIITMPENLGHK;GDMS(1)DEDDENEFFDAPEIITMPENLGHK;GDMS(0.991)DEDDENEFFDAPEIIT(0.009)MPENLGHK;GDMS(1)DEDDENEFFDAPEIITMPENLGHK 150.09 2.1468e-14 89558000.0 194534.0 155117.0 201691.0 216343.0 230509.0 179641.0 185870.0 185025.0 142055.0 186151.0 True False 183722.5790613032 167013.97512023285 188714.42064455722 186876.71018750878 201550.3986433938 204384.91713136507 194513.323294418 185563.39211746232 170469.96934833186 180776.33695161706 1.016297719930428 0.9238707783139363 1.043911077228347 1.0337454190009636 1.1149158238411296 1.1305955224995328 1.075988852160875 1.0264805407973636 0.9429882927318989 1.0 17.46384632034936 -5.386051778512468 6.478229515857746 1.0538511757858329 0.9706050156624733 0.22311346777812868 0.055451604997627094 0.31975999965971774 15.361746339082284 0.015512999104425905 0.03266693675739678 4.111007049350104e-06 5.386051778512468 -0.08324616012335961 GDPEWS(ph)SETDALVGSR ddPTM_A459_Selumetinib_30min_R1 4 GDPEWSSETDALVGSR 16 0 Q7Z7N9 Q7Z7N9 TMEM179B Transmembrane protein 179B 1 GDPEWS(0.883)S(0.116)ETDALVGSR;GDPEWS(0.956)S(0.044)ETDALVGSR;GDPEWS(0.731)S(0.123)ET(0.04)DALVGS(0.105)R;GDPEWS(0.432)S(0.432)ET(0.136)DALVGSR 268.08 2.3795999999999997e-50 13831400.0 1700.6200000000001 1948.4599999999998 2485.9 1770.79 2575.1500000000005 1694.0700000000002 1922.2600000000002 2218.62 1142.51 1614.58 True False 1740.2411371695173 1720.3333973855197 2148.3284340712667 1461.5547683451218 2342.2281371796594 1677.029193892492 1777.2623805795956 2159.7749905065843 1938.756024371155 1821.8270703410124 0.9552175206419434 0.9442901718786653 1.179216441036382 0.8022467072418381 1.2856478945288905 0.9205205154727354 0.975538463289452 1.1854994503415268 1.0641822464567154 1.0 10.831170308235782 -2.9825284870977367 0.5918199841971191 1.057690458986223 2.1881655900294074e-10 0.05477916453525544 0.13528135097503433 82.26063265419307 3.89025673152654 0.0601971155493437 93.9375408204948 0.0010410498187966627 2.9825284870977367 -1.0576904587674065 GDPEWS(ph)SETDALVGSR ddPTM_A459_Selumetinib_30min_R2 2 GDPEWSSETDALVGSR 16 0 Q7Z7N9 Q7Z7N9 TMEM179B Transmembrane protein 179B 1 GDPEWS(0.594)S(0.203)ET(0.203)DALVGSR;GDPEWS(0.68)S(0.311)ET(0.009)DALVGSR 137.27 0.00040769 6197300.0 9720.7 3654.4 8733.4 10245.6 7963.2 6570.1 11117.9 7924.4 7616.700000000001 5822.9 True False 9180.462409045249 3934.6807292519698 8171.502552206959 8850.13160535418 6962.791624088749 7475.07163757038 11634.904379700902 7947.458692044962 9140.25282837942 5654.77774728888 1.6234877512996366 0.6958152742852552 1.4450616659734672 1.5650715202020584 1.2313112796390595 1.3219037019013204 2.0575352205980377 1.4054413890723259 1.616377024324539 1.0 12.465254606987656 -5.487491441316713 24.94864347545763 1.485355682653637 1.1373481410380244 0.10675676197303186 0.33397682033172243 1027.2929035415777 724256.9290579751 0.08371153077970875 0.17413747658975298 3.254681974680373e-06 5.487491441316713 -0.34800754161561254 GDPGS(ph)SPAGPR ddPTM_A459_Selumetinib_30min_R1 1 GDPGSSPAGPR 11 0 H3BRW8;Q9P1Z2-4;Q9P1Z2-2;Q9P1Z2-3;Q9P1Z2 H3BRW8 CALCOCO1 Calcium-binding and coiled-coil domain-containing protein 1 1 GDPGS(0.5)S(0.5)PAGPR 129.0 0.0026686 3604700.0 1269.4 1710.3 1903.4 1844.3 2010.0 1442.2 1805.7 1601.0 887.06 993.29 True False 1298.9745501775735 1510.0572809031016 1644.9287346278006 1522.2276267987218 1828.1958548943235 1427.6927774128294 1669.49459522259 1558.5362792190833 1505.2760317009725 1120.7884469639305 1.1589828157992936 1.3473169579804731 1.4676531856513133 1.3581756940145462 1.6311694324175694 1.2738289561069822 1.4895715598648727 1.3905713281047414 1.3430509885951882 1.0 10.130298274385579 -10.095088878341492 7.052367365892946 1.0000015525317494 1.3923308783628838 0.4752424719408387 0.12095102814712506 0.0 0.0 0.11447197647386616 0.027763532363233537 8.033616974348721e-11 10.095088878341492 0.39232932583113445 GDPPRLS(ph)PDPVAGSAVSQELR ddPTM_A459_Selumetinib_30min_R2 2 GDPPRLSPDPVAGSAVSQELR 21 1 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 GDPPRLS(0.995)PDPVAGS(0.003)AVS(0.001)QELR;GDPPRLS(1)PDPVAGSAVSQELR 74.618 0.0017569000000000007 30788000.0 48661.0 40355.0 51594.0 50660.0 55022.0 45100.0 39114.0 51465.0 49149.0 41921.0 True False 45956.61642541701 43450.09873822332 48274.498211299826 43760.02060662553 48109.64445707897 51312.11562296221 40932.87850292062 51614.75462951059 58980.17333779982 40710.63180616141 1.1288603096172445 1.0672911917728407 1.185795849132306 1.0749039910503821 1.1817464461408271 1.2604106924028702 1.00545918073238 1.2678445983169164 1.44876585602077 1.0 15.313117991018599 -6.674827539239543 0.8092303453520063 1.220451747057786 1.1092877749976005 0.06697834652947776 0.12685766961292066 1.6377460660147463 2.3663014657418815 0.08218299384046447 0.0862155833655058 2.1143284847826094e-07 6.674827539239543 -0.11116397206018558 GDQCCYSHS(ph)PPTPR ddPTM_A459_Selumetinib_30min_R1 4 GDQCCYSHSPPTPR 14 0 Q9NXH9-2;Q9NXH9 Q9NXH9-2 TRMT1 tRNA (guanine(26)-N(2))-dimethyltransferase 1 GDQCCYS(0.028)HS(0.944)PPT(0.028)PR;GDQCCYS(0.001)HS(0.954)PPT(0.045)PR;GDQCCYS(0.052)HS(0.937)PPT(0.011)PR;GDQCCYS(0.006)HS(0.966)PPT(0.028)PR 140.77 0.00055974 25146300.0 4627.61 4921.0 5146.6 5256.1 4919.0 5057.88 4720.67 4362.22 2833.2299999999996 4023.9 True False 4735.424309238413 4344.847032289168 4447.719988250206 4338.220804216642 4474.077318519987 5007.002319387604 4364.586061266777 4246.519755112473 4807.784379068093 4540.406761105177 1.0429515588347347 0.9569290288061311 0.9795862402353551 0.9554696379583135 0.9853912994858979 1.1027651448058484 0.9612764430393007 0.935272978511474 1.0588884723398293 1.0 12.14860583458846 -6.548864778558425 24.99986846968157 1.00885080540025 0.9801365048184172 0.06975177601718208 0.04916512955925243 674.9802737270076 649359.9947362032 0.01651387892099275 0.016514553770063143 2.825759663310758e-07 6.548864778558425 -0.028714300581832886 GDQCCYSHS(ph)PPTPR ddPTM_A459_Selumetinib_30min_R2 4 GDQCCYSHSPPTPR 14 0 Q9NXH9-2;Q9NXH9 Q9NXH9-2 TRMT1 tRNA (guanine(26)-N(2))-dimethyltransferase 1 GDQCCYS(0.003)HS(0.997)PPTPR;GDQCCYS(0.002)HS(0.997)PPT(0.001)PR;GDQCCYS(0.045)HS(0.929)PPT(0.026)PR;GDQCCYS(0.011)HS(0.926)PPT(0.062)PR 101.53 0.005439800000000001 27793600.0 40845.1 34483.6 41144.2 45905.0 43973.6 31603.4 36790.7 37650.9 34517.799999999996 38096.8 True False 38575.09285789031 37128.3812377499 38497.02696641782 39652.659809458055 38449.243239028154 35956.48148289853 38501.54044938904 37760.457885557946 41422.324507914855 36996.84639662625 1.0426589456934898 1.0035552987331278 1.0405488768882845 1.071784859292061 1.0392573147135684 0.9718796325888309 1.0406708733125967 1.0206399075409123 1.1196177118407629 1.0 15.175114680511308 GDQCCYSHSPPT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GDQCCYSHSPPTPR 14 0 Q9NXH9-2;Q9NXH9 Q9NXH9-2 TRMT1 tRNA (guanine(26)-N(2))-dimethyltransferase 1 GDQCCYSHSPPT(1)PR 103.87 0.012266 0.0 7083.6 7180.0 6661.8 6512.4 5377.2 6466.1 6123.0 5537.5 5542.0 7594.4 True False 6689.921869897529 7730.682912661213 6233.187040819419 5625.399885483382 4701.668063222075 7356.746581588382 6407.731632494323 5553.613208217526 6650.554856417965 7375.1299393791205 0.9070920681921876 1.0482097232461811 0.8451630129982718 0.7627526473054872 0.6375030815549112 0.9975073852336375 0.8688296592959773 0.7530190320531573 0.9017542621056309 1.0 12.848452752498023 -3.254791013778954 15.124411769365237 0.8632910321567722 0.9069995010828403 0.0 0.12161563443638836 0.0 0.0 0.02880488768353638 0.0 0.0005561718275293839 3.254791013778954 0.04370846892606817 GDQPAAS(ph)GDSDDDEPPPLPR ddPTM_A459_Selumetinib_30min_R2 1 GDQPAASGDSDDDEPPPLPR 20 0 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 GDQPAAS(0.945)GDS(0.055)DDDEPPPLPR 109.99 0.00038634 15401000.0 41100.0 25963.0 41166.0 45372.0 22862.0 29940.0 53306.0 39540.0 42281.0 28644.0 True False 38815.826536335815 27954.278615797106 38517.424378151896 39192.255328934356 19989.871171126815 34063.96323174034 55784.834623835144 39655.05485380064 50738.381429846275 27816.973293950217 1.3954007909544093 1.0049360266624245 1.3846734499518274 1.4089331328314607 0.7186213596960356 1.2245747541177943 2.005424315375373 1.4255704398445475 1.8240079858322016 1.0 14.763677831372066 -7.035564889574662 24.51920132719444 1.6014700023049484 1.1739716495929127 0.25087574577554583 0.3146361392410316 589.9521298327318 406723.8660886406 0.11479657355413271 0.08896297202069359 9.213722127564703e-08 7.035564889574662 -0.42749835271203573 GDQPAASGDS(ph)DDDEPPPLPR ddPTM_A459_Selumetinib_30min_R1 1 GDQPAASGDSDDDEPPPLPR 20 0 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 GDQPAAS(0.003)GDS(0.997)DDDEPPPLPR 188.27 1.3454000000000001e-15 12332000.0 1555.5 1764.2 1269.1 1116.4 1581.0 1492.9 1828.3 1661.4 1236.2 1431.7 True False 1591.7401235238826 1557.6466438456719 1096.7631906673025 921.4416974234629 1437.9988291482202 1477.8827814447466 1690.3898590272252 1617.3342750122333 2097.7411115242953 1615.4726409389605 0.9853092421291123 0.9642049047270287 0.6789116465815425 0.5703852074448588 0.8901412457919515 0.9148299661613318 1.0463747984272396 1.0011523773452398 1.2985308809098903 1.0 10.657740602510232 -7.201314527976495 1.4971130850508005 1.1137662730979891 0.8036004080507662 0.46290916485521183 0.13856542651195783 0.3937157554915244 1.7336254204632966 0.08440874961626656 0.0528497968563756 6.290504422620526e-08 7.201314527976495 -0.310165865047223 GDQPAASGDS(ph)DDDEPPPLPR ddPTM_A459_Selumetinib_30min_R2 2 GDQPAASGDSDDDEPPPLPR 20 0 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 GDQPAAS(0.028)GDS(0.972)DDDEPPPLPR;GDQPAAS(0.499)GDS(0.501)DDDEPPPLPR 254.36 1.875e-38 58169000.0 101985.0 51159.0 97099.0 101399.0 72568.0 71040.0 134867.0 92228.0 95132.0 73035.0 True False 96317.08197830187 55082.73079788788 90851.7560533977 87588.28127696826 63451.359073848835 80825.11516308729 141138.5827338906 92496.36821083268 114161.05821016831 70926.28978228079 1.35798844510212 0.7766193743811053 1.2809320258014512 1.2349198237470764 0.8946098727090137 1.1395649682394564 1.989933255597287 1.3041196500587382 1.6095732423140041 1.0 16.114032860446777 -7.038090084727772 24.974918144725326 1.5103212748352444 1.098092604498296 0.2772046185556708 0.2841256004742636 625.9175066607797 410399.9355100791 0.10180059342856987 0.07887323233712511 9.160304602754759e-08 7.038090084727772 -0.41222867033694843 GDQVLNFS(ph)DAEDLIDDSK ddPTM_A459_Selumetinib_30min_R1 3 GDQVLNFSDAEDLIDDSK 18 0 F8W126;Q96EZ8-3;Q96EZ8;Q96EZ8-2;Q96EZ8-4 F8W126 MCRS1 Microspherule protein 1 1 GDQVLNFS(0.884)DAEDLIDDS(0.116)K;GDQVLNFS(0.999)DAEDLIDDS(0.001)K;GDQVLNFS(1)DAEDLIDDSK 166.59 1.4385e-07 92701800.0 8828.3 12483.3 9946.9 11071.5 8657.7 9543.4 9816.3 8642.800000000001 5126.3 8386.1 True False 9033.982213118537 11021.749432671277 8596.165614410676 9138.07036279458 7874.612563641081 9447.402060713906 9075.848587851528 8413.564868229041 8698.95668986167 9462.537622531405 0.9547103085336827 1.1647773432812787 0.9084418955378528 0.9657103334559822 0.8321882435522063 0.9984004753881814 0.9591347426974425 0.8891446675144903 0.9193048457898271 1.0 13.208011415848338 -5.287868993592622 24.98673606768403 0.9307697806588713 1.059743860202804 0.35621608240947866 0.06748124564774102 628.5224729908305 594208.506374504 0.01655424106207026 0.03447579323730581 5.153840884984549e-06 5.287868993592622 0.1289740795439327 GDQVLNFS(ph)DAEDLIDDSK ddPTM_A459_Selumetinib_30min_R2 4 GDQVLNFSDAEDLIDDSK 18 0 F8W126;Q96EZ8-3;Q96EZ8;Q96EZ8-2;Q96EZ8-4 F8W126 MCRS1 Microspherule protein 1 1 GDQVLNFS(1)DAEDLIDDSK;GDQVLNFS(1)DAEDLIDDSK;GDQVLNFS(1)DAEDLIDDSK;GDQVLNFS(1)DAEDLIDDSK 190.71 2.3258e-10 72254000.0 288446.0 252284.0 298853.0 270771.0 286616.0 233783.0 245509.0 276656.0 198067.0 259181.0 True False 272415.3260608258 271633.3715790843 279625.12334654323 233891.52269397138 250608.7357004498 265984.4861792237 256925.65496685414 277461.02315713384 237685.93445437364 251697.7710968902 1.0823112372972123 1.079204517367458 1.110955898131106 0.9292554386742488 0.9956732417943376 1.0567613889470395 1.0207704813879797 1.1023578871913258 0.9443307082877473 1.0 17.941332915243606 -5.720659564281296 24.999989470153782 1.0134585657008965 1.089662019384618 0.38782877667213345 0.0477648686894775 173.62362337833207 106438.44303556842 0.013079268215160986 0.022653596499201397 1.902569085600358e-06 5.720659564281296 0.0762034536837215 GDQVLNFS(ph)DAEDLIDDSKLK ddPTM_A459_Selumetinib_30min_R1 1 GDQVLNFSDAEDLIDDSKLK 20 1 F8W126;Q96EZ8-3;Q96EZ8;Q96EZ8-2;Q96EZ8-4 F8W126 MCRS1 Microspherule protein 1 1 GDQVLNFS(0.999)DAEDLIDDS(0.001)KLK 52.666 0.031643 62950000.0 1632.7 2131.2 2039.9 2288.6 1733.1 1731.5 1627.4 1562.7 964.66 1322.0 True False 1670.7387333188315 1881.6781132319995 1762.8927843686315 1888.9389723426516 1576.3414110036576 1714.082682076212 1504.6439077727432 1521.2521196350172 1636.957564021216 1491.6915773704734 1.1200296084422352 1.2614391217177663 1.1818078288517433 1.2663066554766225 1.0567475441420695 1.1490865190093555 1.0086829815216238 1.0198167923671275 1.0973833926895362 1.0 10.542733558998561 -6.624109678967695 1.4086671584992738 1.038875576421107 1.208075489845847 0.5913365666183537 0.05971859440277726 0.27323606222863195 1.127219137811279 0.024770057327213286 0.025229448353263437 2.376240102913767e-07 6.624109678967695 0.16919991342473995 GDREEEVERPVS(ph)SPGDPEQK ddPTM_A459_Selumetinib_30min_R2 1 GDREEEVERPVSSPGDPEQK 20 2 O43149 O43149 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 1 GDREEEVERPVS(0.5)S(0.5)PGDPEQK 67.418 0.016413999999999998 13643000.0 59280.0 36357.0 55507.0 57655.0 42608.0 42262.0 52873.0 54094.0 39210.0 47103.0 True False 55985.45491664203 39145.46499381949 51935.740051452085 49802.289539577476 37255.20211964706 48083.2068837612 55331.699265861884 54251.404584256255 47053.09561893696 45743.01400170847 1.223912681279616 0.8557692545654608 1.1353808048046925 1.0887408848423803 0.814445723192958 1.0511595690210822 1.2096207579106022 1.1860041531638035 1.0286400370814996 1.0 15.481263807434166 -7.011988632780245 24.794268691557537 1.122827106521561 1.0150122271583815 0.07668066215558877 0.1283087430005428 1081.970700585036 2237674.429178926 0.04624555419608262 0.0379053896291271 9.727726847870161e-08 7.011988632780245 -0.10781487936317946 GDREEEVERPVSS(ph)PGDPEQK ddPTM_A459_Selumetinib_30min_R1 2 GDREEEVERPVSSPGDPEQK 20 2 O43149 O43149 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 1 GDREEEVERPVS(0.281)S(0.719)PGDPEQK;GDREEEVERPVS(0.233)S(0.767)PGDPEQK 100.39 0.00086177 34129000.0 8606.7 10683.2 7702.8 7370.5 8963.5 8761.0 9685.3 9912.3 4990.0 8522.0 True False 8807.219364277085 9432.405977515069 6656.8020684517305 6083.380536420309 8152.753007634454 8672.872294351544 8954.730023320233 9649.393604311881 8467.665544819803 9615.881711309512 0.9159034635293677 0.9809195101080901 0.6922716260769386 0.6326388696384931 0.8478424810535855 0.9019320905488191 0.9312437790065908 1.003485056701868 0.8805916918529417 1.0 13.231203433669089 -6.847577832334479 2.6288018201656556 0.9511433876379638 0.8044323554247181 0.314652643099263 0.09853790828205913 0.38575202720450935 5.423848043888678 0.04248869614770818 0.03740891163863664 1.4204376255047124e-07 6.847577832334479 -0.14671103221324566 GDRS(ph)PEPGQTWTR ddPTM_A459_Selumetinib_30min_R1 2 GDRSPEPGQTWTR 13 1 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GDRS(1)PEPGQTWTR;GDRS(1)PEPGQTWTR 185.2 0.00052417 22918000.0 6044.4 7089.5 6048.799999999999 5728.5 6358.6 5248.3 6452.2 6041.7 2821.8 5384.4 True False 6185.222759644974 6259.458044180866 5227.406183680066 4728.125012262906 5783.465752702006 5195.506867075131 5965.505359303977 5881.454489792591 4788.388503882268 6075.54018849741 1.0180531389382004 1.030271852374816 0.8604018772811207 0.7782229835652287 0.9519261782930221 0.8551514278370814 0.9818888813538329 0.9680545774230456 0.7881420178814622 1.0 12.568796972001008 -5.253100379609823 24.34733028126154 0.8959502813267148 1.0241625226492994 0.316188685782798 0.07418176547412952 502.20217570573584 1466263.677295063 0.01889009592040273 0.04812682110655579 5.583411289887114e-06 5.253100379609823 0.12821224132258457 GDRS(ph)PEPGQTWTR ddPTM_A459_Selumetinib_30min_R2 4 GDRSPEPGQTWTR 13 1 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GDRS(0.997)PEPGQT(0.001)WT(0.002)R;GDRS(1)PEPGQTWTR;GDRS(1)PEPGQTWTR;GDRS(1)PEPGQTWTR 82.85 0.017715 89876000.0 51520.5 48237.2 45978.1 65200.0 48511.0 26629.9 43092.5 46102.8 38760.5 45869.799999999996 True False 48657.19686290247 51936.83813295563 43019.919103170236 56319.64752372652 42416.61448615751 30297.92700283639 45096.386636168834 46236.95151527059 46513.68305885759 44545.41968994683 1.0923052740680228 1.1659299316171203 0.9657540416636623 1.264319607172473 0.952210458031227 0.6801580771653193 1.0123686554096234 1.037973193138542 1.0441855387739216 1.0 15.442989476160491 -6.398037992805751 11.15759140053906 0.9448970596909053 1.1139400597914286 0.31647363351527014 0.11997640073176802 0.6237399216813999 53.51138323023235 0.038695603499829645 0.04387108853753439 3.999097634575677e-07 6.398037992805751 0.1690430001005233 GDRSEDFGVNEDLADSDAR ddPTM_A459_Selumetinib_30min_R1 6 GDRSEDFGVNEDLADSDAR 19 1 P04083 P04083 ANXA1 Annexin A1 0 ;;;;; 311.33 3.631599999999999e-115 168249200.0 8944.26 10130.4 16640.18 17428.699999999997 13103.090000000002 11613.919999999998 10127.859999999999 10014.13 6201.64 7992.83 False True 9152.643855499666 8944.328058504807 14380.534953965973 14385.104722218108 11917.917823038439 11497.094509395647 9363.907366213134 9748.522741921419 10523.730130135522 9018.787587257208 1.014841936008293 0.9917439536044063 1.5945086648103861 1.5950153591091398 1.3214545422798802 1.2747938010692346 1.0382667598739714 1.0809127776437784 1.1668675005723244 1.0 13.138717786943575 -7.170922065480168 4.504211507890467 1.0784868948682764 1.3164786947036817 0.25072646324053316 0.19170699447088532 0.37282445292800864 13.165604269166158 0.08533830511738298 0.06490157246307017 6.746490831964433e-08 7.170922065480168 0.2379917998354053 GDRSEDFGVNEDLADSDAR ddPTM_A459_Selumetinib_30min_R2 4 GDRSEDFGVNEDLADSDAR 19 1 P04083 P04083 ANXA1 Annexin A1 0 ;;; 313.32 2.3965999999999982e-115 214915000.0 896377.0 1154694.0 1059576.0 1071522.0 1135967.0 791155.0 597301.2 663838.0 582074.3 1043568.0 False True 846559.9548214391 1243255.316873595 991404.0337391187 925578.8551214499 993256.6697861707 900129.4198599699 625076.8893298745 665769.6586757031 698505.4245148129 1013437.4803247099 0.8353351551101086 1.2267706109263399 0.9782587016827801 0.91330631942376 0.9800867730567127 0.8881943260787675 0.6167888019393136 0.6569420132975421 0.6892437255142849 1.0 19.950825659996184 -7.03003513859275 3.665363409962007 0.7129851521971274 0.9936473825230724 0.41617043603926684 0.1351578902944224 0.2005112829521384 5.690705119982224 0.051453135410875366 0.04116576793036553 9.331787946195782e-08 7.03003513859275 0.28066223032594495 GDS(ph)ETDLEALFNAVMNPK ddPTM_A459_Selumetinib_30min_R1 3 GDSETDLEALFNAVMNPK 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 GDS(0.95)ET(0.05)DLEALFNAVMNPK;GDS(0.99)ET(0.01)DLEALFNAVMNPK;GDS(0.999)ET(0.001)DLEALFNAVMNPK 231.06 6.5955e-19 10795200.0 2478.0699999999997 3462.7799999999997 3034.56 3329.04 3184.17 2620.5299999999997 3165.3399999999997 3183.54 1777.21 2805.09 True False 2535.8042095151563 3057.356107797253 2622.4834196449206 2747.6856578203187 2896.162385710873 2594.1698474508657 2926.5758553701457 3099.1021776046964 3015.795567717275 3165.1506253904245 0.8011638337756398 0.9659433213925246 0.8285493267232534 0.8681058132838114 0.9150156591216345 0.8196039160477149 0.9246245129358258 0.9791326051733854 0.952812654009246 1.0 11.628058441924882 -7.534823094929486 4.3681360176945505 0.9726719003245651 0.8712064452471162 0.5339905284300711 0.046442249072156674 0.16306918191094344 7.656468703524265 0.020989361598671197 0.012297709576512082 2.9186156378101112e-08 7.534823094929486 -0.10146545507744886 GDS(ph)ETDLEALFNAVMNPK ddPTM_A459_Selumetinib_30min_R2 1 GDSETDLEALFNAVMNPK 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 GDS(0.995)ET(0.005)DLEALFNAVMNPK 197.1 2.4876e-10 13134000.0 8865.8 5843.3 7021.9 8143.1 8050.7 4832.8 7334.2 6863.3 5154.6 5290.9 True False 8373.0743286094 6291.46232082915 6570.11859886665 7033.9957323689805 7039.299091828823 5498.4743322095765 7675.254832441596 6883.2710667195215 6185.6640315575705 5138.137969590881 1.6295931285154062 1.2244634842551925 1.2786964144891948 1.3689775895467158 1.3700097454544065 1.0701297561006107 1.4937813810890583 1.339643097841453 1.20387270022064 1.0 12.327029914755256 -13.89990406967191 0.17293905221574474 7.680749543914892e-12 1.4029440579386825 0.36715814187800144 0.14132645165083213 123.65406228819185 1.4230958200360362 43.20174041816904 0.49323944991949503 1.2592035237021444e-14 13.89990406967191 1.4029440579310017 GDS(ph)LILEHQWELEK ddPTM_A459_Selumetinib_30min_R1 4 GDSLILEHQWELEK 14 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 GDS(1)LILEHQWELEK;GDS(1)LILEHQWELEK;GDS(1)LILEHQWELEK;GDS(1)LILEHQWELEK 129.05 0.0007172000000000001 18300300.0 13059.8 12392.8 9878.6 9239.599999999999 10508.4 9974.5 11655.2 12183.5 7288.92 12414.099999999999 True False 13364.06793005285 10941.84521474358 8537.140379265633 7626.0773087726875 9557.9170754087 9874.165586121384 10776.03888034465 11860.354002414559 12368.76487834628 14007.570658573959 0.9540603617710667 0.7811379632803163 0.6094661656437974 0.54442540356595 0.6823393797809152 0.7049163503649692 0.7693010546228224 0.846710274858039 0.8830057102567906 1.0 13.773919149541586 -8.092766354301496 1.1008947738290924 0.9855701389855829 0.7017383415429994 0.45106249825737554 0.10308006567768105 0.47402853260414585 1.0817252934970003 0.10483478362727602 0.036366899279428815 8.076694307390895e-09 8.092766354301496 -0.28383179744258347 GDS(ph)LILEHQWELEK ddPTM_A459_Selumetinib_30min_R2 2 GDSLILEHQWELEK 14 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 GDS(1)LILEHQWELEK;GDS(1)LILEHQWELEK 86.367 0.015492 5591200.0 39909.0 28114.0 35143.0 40735.0 43040.0 27473.0 37217.0 39441.0 29141.0 32857.0 True False 37691.01754838507 30270.25339924198 32881.93764080533 35186.82272820551 37632.93041751808 31257.156374936614 38947.66424408642 39555.766780190956 34970.014267570536 31908.33303726163 1.1812280354592823 0.9486629515836272 1.030512549884908 1.1027471315131177 1.1794075978074892 0.9795922694687751 1.2206110610229768 1.239668858100449 1.0959524029893246 1.0 14.96164562051722 -5.899590682106534 4.683770510091137 1.1302013866167113 1.043666623942007 0.07637078883707227 0.09570335845663405 0.42884036456273333 16.024164838681454 0.027193958999167753 0.04128306188876746 1.2601124948174791e-06 5.899590682106534 -0.08653476267470439 GDS(ph)LKEPTSIAESSR ddPTM_A459_Selumetinib_30min_R2 1 GDSLKEPTSIAESSR 15 1 Q9C0B5-2;Q9C0B5;H0YEF4 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5;Palmitoyltransferase 1 GDS(0.999)LKEPT(0.001)SIAESSR 149.31 0.0013661 16029000.0 43686.0 15929.0 27759.0 33991.0 22410.0 17269.0 57702.0 32200.0 18895.0 18321.0 True False 41258.107008914034 17150.703080192266 25973.016161714004 29361.36716225441 19594.65545205808 19647.64799762603 60385.25733434391 32293.696669003024 22674.52797041096 17792.02512632531 2.3189101137153862 0.9639545222323156 1.4598122460654575 1.6502543669866425 1.1013167592184645 1.104295202942082 3.393950767582781 1.8150658196419056 1.2744208604371539 1.0 14.118943110133541 GDS(ph)PELKPR ddPTM_A459_Selumetinib_30min_R2 1 GDSPELKPR 9 1 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 GDS(1)PELKPR 112.85 0.044896 5611000.0 42860.0 31890.0 39367.0 40717.0 48271.0 39635.0 42153.0 40478.0 29000.0 27097.0 True False 40478.01278217406 34335.86045748833 36834.170079548785 35171.27435925725 42206.76543178471 45094.361479292864 44113.19802458489 40595.78427850637 34800.8103277014 26314.63920353892 1.5382317222396262 1.3048197314014731 1.3997596468886848 1.3365668473435595 1.6039271944913667 1.7136606407747499 1.6763747997218343 1.542707234726093 1.3224885987804544 1.0 14.683577993919048 -8.591293569824328 3.008982886386465 1.000740757500375 1.511739044113804 0.6035043819848458 0.12838124402883588 0.2526090100291206 5.689089571182452 0.14313927921683847 0.03812088892469019 2.5627511092915474e-09 8.591293569824328 0.510998286613429 GDS(ph)VSDSGSDALR ddPTM_A459_Selumetinib_30min_R2 1 GDSVSDSGSDALR 13 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 1 GDS(0.991)VS(0.009)DSGSDALR 172.58 8.3106e-10 0.0 14076.0 11484.0 14943.0 17118.0 16022.0 20644.0 14172.0 17767.0 20551.0 13992.0 True False 13293.712270692542 12364.78587311997 13981.583648708245 14786.498869802921 14009.173121502667 23487.523612426427 14831.026081285247 17818.699028514813 24661.774242916945 13588.01460441808 0.9783410349272184 0.9099773758779753 1.0289644260584028 1.088201573244936 1.0309948531367967 1.7285471274655215 1.0914785208181192 1.3113541269466362 1.8149652440687165 1.0 13.730047053490786 -6.621433625099623 11.531658707049514 1.389986908896185 1.0046685699882696 0.39492313321699635 0.23661120689923093 0.444621584378859 48.84649503497699 0.0754272647163803 0.07541350527284835 2.39092732206461e-07 6.621433625099623 -0.38531833890791534 GDSVSDS(ph)GSDALR ddPTM_A459_Selumetinib_30min_R2 1 GDSVSDSGSDALR 13 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 1 GDS(0.272)VS(0.272)DS(0.436)GS(0.02)DALR 176.99 0.00010276 13437000.0 20975.0 12815.0 18609.0 21851.0 24335.0 21218.0 22787.0 35398.0 23689.0 23465.0 True False 19809.29346957771 13797.86929328043 17411.717199947234 18874.85610492251 21277.819742339736 24140.586902173225 23846.6406515839 35501.00231954565 28427.46192596269 22787.504480608208 0.8693050828112878 0.6055015504230483 0.7640905661593757 0.8282985142574388 0.9337494485386415 1.0593782624471437 1.0464788135039973 1.557915319325836 1.2475021979767023 1.0 14.475955319484758 -6.827408350720537 1.0914966710948912 1.2799223300303513 0.7391880471001391 0.6361070954416534 0.15256922493524722 0.28746607298504906 0.72463616580282 0.08406218942124785 0.07120573594006235 1.487961345826202e-07 6.827408350720537 -0.5407342829302122 GDT(ph)PGHATPGHGGATSSAR ddPTM_A459_Selumetinib_30min_R1 1 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GDT(0.924)PGHAT(0.075)PGHGGATSSAR 83.758 0.0058998 12412000.0 299.88 302.31 216.43 275.9 302.54 250.58 367.75 347.01 55.304 125.48 True False 306.86662053509605 266.9154046598939 187.0399947648918 227.71924428442603 275.1753104177753 248.05939270843615 340.0103214227762 337.8061675526635 93.84684875565412 141.58658027870422 2.1673425541534272 1.8851744574555571 1.3210291144592616 1.6083391790109989 1.943512654067286 1.7519979098311926 2.4014304233740753 2.385862889602344 0.6628230484197198 1.0 7.1455407215597475 -4.896665998261847 4.323120576162678 1.7188869132802491 2.15552243211342 0.07502988909709096 0.5261807043831128 0.661846283810848 20.50157736317258 0.13120295403618706 0.6558452884072775 1.2686271505937577e-05 4.896665998261847 0.436635518833171 GDTGGEDTAAPGR ddPTM_A459_Selumetinib_30min_R1 1 GDTGGEDTAAPGR 13 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 166.86 0.0044463 689750.0 154.19 151.61 138.78 160.7 249.77 185.52 50.882 238.33 174.61 148.23 False True 157.7823269984876 133.85943071842317 119.93443826397302 132.63676171260343 227.17834760047515 183.6538372386826 47.04392977466679 232.0087141950557 296.3004169901773 167.2567643824699 0.943353935974052 0.8003229717652778 0.717067789196951 0.7930128398831147 1.3582610451615649 1.098035334575271 0.28126772599217786 1.3871409927823068 1.7715302462304026 1.0 7.3859207488848115 -7.96352926043348 24.999354530637568 1.450289526694112 0.87175231401872 0.3713191377295858 0.31350904413306574 159.15813923113774 109096.91747032572 0.17106827540880729 0.08217819035380756 1.0876038582462628e-08 7.96352926043348 -0.578537212675392 GDTGGEDTAAPGRFS(ph)FSPEPTLEDIRR ddPTM_A459_Selumetinib_30min_R1 2 GDTGGEDTAAPGRFSFSPEPTLEDIRR 27 2 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 1 GDTGGEDT(0.003)AAPGRFS(0.959)FS(0.038)PEPTLEDIRR;GDTGGEDT(0.008)AAPGRFS(0.728)FS(0.219)PEPT(0.045)LEDIRR 87.802 1.8094e-05 10460900.0 1354.69 1709.9099999999999 1715.61 1851.16 1714.1599999999999 1090.0 1464.23 1441.78 942.98 1221.2 True False 1386.251641232124 1509.7129422844066 1482.6395851711684 1527.88965657687 1559.1145306595279 1079.035589640815 1353.7819522416648 1403.5393108385317 1600.1681874657656 1377.952915495326 1.0060225031229133 1.0956201226525346 1.0759726029087222 1.108811222354174 1.1314715569211453 0.7830714515037979 0.9824587886989067 1.0185684104699677 1.1612647786956938 1.0 10.428310876810286 GDTPGHAT(ph)PGHGGATSSAR ddPTM_A459_Selumetinib_30min_R1 2 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GDT(0.001)PGHAT(0.999)PGHGGATSSAR;GDT(0.023)PGHAT(0.977)PGHGGATSSAR 91.166 0.0034328 987670.0 278.0 305.571 359.89 342.85 450.05999999999995 319.09 356.55 178.65 287.77 211.21 True False 284.4768591061647 269.7946052638963 311.0189147342647 282.977683591575 409.35215246454646 315.8802443105393 329.65514643994834 173.9116216630164 488.32467211078017 238.32086085961987 1.1936716663411704 1.1320645800403335 1.3050427629894588 1.187381090228017 1.717651367102398 1.3254410175054079 1.3832408344401201 0.7297373005271957 2.0490219376910614 1.0 7.896761429769121 -5.62248880914 2.0338057654588253 1.3509772871039958 1.1704053816620934 0.04140875195547211 0.3406293301452817 1.2456688572493435 10.33565173004367 0.097106608779734 0.22103224475549582 2.385125254359993e-06 5.62248880914 -0.18057190544190238 GDTPGHAT(ph)PGHGGATSSAR ddPTM_A459_Selumetinib_30min_R2 4 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GDT(0.001)PGHAT(0.999)PGHGGATSSAR;GDTPGHAT(0.989)PGHGGAT(0.001)S(0.005)S(0.005)AR;GDT(0.001)PGHAT(0.998)PGHGGATSSAR;GDTPGHAT(0.992)PGHGGAT(0.001)S(0.002)S(0.006)AR 106.23 0.0011263 50735500.0 10346.4 6635.360000000001 14524.4 21023.2 21149.2 13753.9 10858.099999999999 13914.099999999999 14992.2 16859.1 True False 9771.388507920805 7144.2707759548375 13589.915916971022 18159.803892957174 18492.24841975309 15648.374879526822 11363.023164916975 13954.587727396744 17991.05891706774 16372.333977797663 0.5968231848416771 0.43636238948234884 0.8300536707472589 1.109176243141844 1.1294815048868547 0.9557815581301606 0.6940380754708669 0.8523273313579116 1.0988695284047596 1.0 13.998972381152225 -5.413771730333203 4.254018974535875 0.9651978241680853 0.5211518378386075 0.6612060430549591 0.12972402461497273 0.1460105557249108 4.393446513234185 0.03838259595681408 0.08395625630587572 3.856810223299585e-06 5.413771730333203 -0.4440459863294778 GDTPGHATPGHGGATSS(ph)AR ddPTM_A459_Selumetinib_30min_R1 1 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GDTPGHATPGHGGAT(0.1)S(0.067)S(0.833)AR 87.74799999999998 0.0021742 8651700.0 1197.6 1302.4 1092.2 1215.3 1549.4 1351.0 1801.7 1455.5 834.15 1124.4 True False 1225.501749876054 1149.914402530666 943.8852390251575 1003.0706690063902 1409.2570435687883 1337.410166609855 1665.796318443009 1416.8954118696909 1415.4916260944767 1268.7276925834792 0.9659296924311589 0.906352410570564 0.7439620373566111 0.7906114723198497 1.1107639975124628 1.0541349214869893 1.3129659959190996 1.1167844921745984 1.1156780405826452 1.0 10.30916674098385 -6.2896781218913365 8.955676317901846 1.1310204727624602 0.847935428830749 0.6573060284596508 0.09405176918496212 0.22107580721970727 66.98279845724105 0.030212397701108416 0.03466848620976344 5.132416329895027e-07 6.2896781218913365 -0.2830850439317112 GDTPGHATPGHGGATSSAR ddPTM_A459_Selumetinib_30min_R1 1 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 105.5 0.00048567 322710.0 308.41 146.15 189.71 233.35 480.08 247.4 206.18 360.15 46.967 178.91 False True 315.59535293860546 129.03869005670833 163.9484240024378 192.59980302200378 436.65684876500796 244.91138062122727 190.62767660352966 350.5976520679283 79.69956866604238 201.87484123097676 1.5633218632603874 0.6392014441713797 0.8121290548278617 0.9540555021496667 2.163007763138763 1.2131842637142183 0.944286447192404 1.736708001502719 0.3947969354678202 1.0 7.657317314941671 -4.455553947121175 20.589070210384754 1.1352350808793228 11.982284380314809 0.07048799211285561 0.49096170119051297 533.8130897176496 163824.0192987448 0.11910941454673556 927.4182309463995 3.503047714978292e-05 4.455553947121175 10.847049299435486 GDTPGHATPGHGGATSSAR ddPTM_A459_Selumetinib_30min_R2 3 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 ;; 119.51 0.00025001 1171150.0 1883.06 546.85 5069.200000000001 10255.1 9287.7 2397.02 2768.6000000000004 4950.5199999999995 5847.200000000001 5286.4 False True 1778.4070636864367 588.7916366001095 4743.053190927648 8858.33768896576 8120.89609290852 2727.1877470189124 2897.345385876825 4964.925193597295 7016.803384418464 5133.767896283283 0.3464136087987067 0.11468996037518167 0.9238931885412072 1.7255041263900865 1.5818588329222754 0.5312253693809038 0.564370155490362 0.9671113486045549 1.3667940440974065 1.0 12.325802356101216 -5.339425712946189 4.968584398616754 1.0922420991507924 0.23209495901049276 0.4622885721537965 0.3702696021091716 0.19904481966273477 8.775988424522858 0.1100212283812528 0.2408439762446081 4.576930176172128e-06 5.339425712946189 -0.8601471401402996 GDTVS(ph)ASPCSAPLAR ddPTM_A459_Selumetinib_30min_R1 2 GDTVSASPCSAPLAR 15 0 Q15477 Q15477 SKIV2L Helicase SKI2W 1 GDT(0.043)VS(0.478)AS(0.478)PCS(0.002)APLAR;GDT(0.325)VS(0.463)AS(0.208)PCS(0.004)APLAR 148.18 0.00030965 46405000.0 7111.299999999999 8996.7 8815.2 9102.9 8167.5 6548.5 8156.8 7857.8 4004.2000000000003 6359.1 True False 7276.979453818959 7943.36218154764 7618.14425842755 7513.24939759588 7428.751067089239 6482.628035562271 7541.526008922645 7649.385618268406 6794.834944803094 7175.352427879404 1.0141633497394065 1.107034429512365 1.06171011598367 1.047091341242501 1.0353151488734225 0.9034577884111178 1.0510321388006665 1.06606409861447 0.9469688092813627 1.0 12.808833978257681 -6.531049585262025 24.99977866795533 0.997690985091379 1.0588218093307404 0.2811127928520166 0.048417877186036865 270.6190817316314 827988.4401066153 0.016197591475105712 0.01622590661935215 2.944085475754148e-07 6.531049585262025 0.06113082423936145 GDTVS(ph)ASPCSAPLAR ddPTM_A459_Selumetinib_30min_R2 1 GDTVSASPCSAPLAR 15 0 Q15477 Q15477 SKIV2L Helicase SKI2W 1 GDT(0.218)VS(0.45)AS(0.329)PCS(0.003)APLAR 110.84 0.0034006 2732700.0 11927.0 13392.0 13432.0 14699.0 14762.0 13182.0 10048.0 11725.0 11385.0 15962.0 True False 11264.145087563933 14419.123337933004 12567.79974365583 12696.97084281068 12907.465586045584 14997.70084571813 10515.251909734285 11759.117808821757 13662.318123478624 15501.135585743386 0.7266657997575175 0.9301978721607 0.8107663902517319 0.8190993990458522 0.8326787101918367 0.9675227187556328 0.6783536503870923 0.7585971843015672 0.88137530620944 1.0 13.920086288204407 -12.378357504509834 1.018583558628728 2.3097914230540706 0.8238878503350054 0.28643259114330577 0.08390185022278766 24886.23444132353 948.2711036665615 74006.94384282803 0.02526895568404032 4.1844896257857404e-13 12.378357504509834 -1.485903572719065 GDTVSAS(ph)PCSAPLAR ddPTM_A459_Selumetinib_30min_R2 2 GDTVSASPCSAPLAR 15 0 Q15477 Q15477 SKIV2L Helicase SKI2W 1 GDTVS(0.006)AS(0.994)PCSAPLAR;GDTVS(0.022)AS(0.941)PCS(0.037)APLAR 227.74 1.0047e-13 56245000.0 115139.0 117117.0 127047.0 163655.0 148121.0 115698.0 120867.0 118141.0 103284.0 132941.0 True False 108740.03531793595 126099.49730949104 118872.93433831443 141364.90667937853 129512.71576145882 131634.34929812595 126487.55499341681 118484.77075070453 123943.68599607989 129102.64790780026 0.8422757943399701 0.9767382726305199 0.9207629453364004 1.0949806914908164 1.0031762931303425 1.0196099881091032 0.9797440799490724 0.9177563177117902 0.9600398442996716 1.0 16.978159065200245 -4.145186970689238 1.4372464354869152 0.9899199165612924 0.3269364139568591 0.44552108881788066 0.04812311473393407 6.461623151209102 3.292662924063261 0.01438545759384878 9.669778093404513 7.1583516542937e-05 4.145186970689238 -0.6629835026044333 GDVEEDETIPDSEQDIRPR ddPTM_A459_Selumetinib_30min_R1 2 GDVEEDETIPDSEQDIRPR 19 1 Q92973-3;Q92973-2;Q92973 Q92973-3 TNPO1 Transportin-1 0 ; 166.9 1.7535e-08 7393400.0 1639.24 2089.78 1991.48 1927.65 2154.0 1693.44 1891.13 1846.1999999999998 1168.8 1473.24 False True 1677.4311025942081 1845.107586087636 1721.0479544166085 1591.0221139719974 1959.1710803195872 1676.4055311204975 1748.4805415425017 1797.2327786972348 1983.3682342255272 1662.3447045728253 1.0090753728633313 1.1099428301555396 1.035313524133894 0.9570951858512667 1.1785588602233 1.0084584301372592 1.0518158699171907 1.0811432633396405 1.193114898955446 1.0 10.699003855707572 -8.000349344664972 14.93550355220799 1.1100791884461088 1.0526088622882737 0.06102780180106271 0.07171470494600406 0.2222533203150508 7213.5397561595055 0.038738706463157746 0.01781160011271934 9.99195927621704e-09 8.000349344664972 -0.057470326157835094 GDVEEDETIPDSEQDIRPR ddPTM_A459_Selumetinib_30min_R2 2 GDVEEDETIPDSEQDIRPR 19 1 Q92973-3;Q92973-2;Q92973 Q92973-3 TNPO1 Transportin-1 0 ; 265.56 1.1673e-47 40621000.0 79289.0 68327.0 87627.0 88390.0 105672.0 73046.0 70522.0 66890.0 64859.0 82867.0 False True 74882.43479901543 73567.46119406729 81989.17422106398 76351.12951874509 92396.53864033378 83107.42345443241 73801.41273669188 67084.63882576433 77832.6123118753 80474.41439567714 0.9305123294322214 0.9141720601078288 1.0188228747827732 0.948762784943564 1.1481480087079337 1.032718586131106 0.9170792144423021 0.8336145013236396 0.9671721490160511 1.0 16.29624255294204 -10.74630008750714 4.9036532450084085 1.00000482119918 0.9690095752088408 0.013999957982299915 0.08035040092698197 4.636636085086282e-06 7.341531354546683e-07 0.08517507244038264 0.02065477607859231 1.793493935486842e-11 10.74630008750714 -0.030995245990339315 GDVEGSQS(ph)QDEGEGSGESER ddPTM_A459_Selumetinib_30min_R1 2 GDVEGSQSQDEGEGSGESER 20 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 GDVEGSQS(1)QDEGEGSGESER;GDVEGSQS(1)QDEGEGSGESER 316.54 4.4150999999999975e-118 10691000.0 1400.5 2327.13 1826.5 1919.3899999999999 1820.8999999999999 1639.56 2162.12 2079.21 872.48 1698.3899999999999 True False 1433.1289251013798 2054.6685377466133 1578.4713322463367 1584.2045679125933 1656.1999165060056 1623.0675150013722 1999.029547667202 2024.062596574085 1480.5348365820403 1916.3949002195427 0.7478254742470877 1.0721529980648716 0.8236670490333212 0.8266587266179358 0.8642268440164764 0.8469379222494451 1.0431198431169864 1.0561824164436087 0.772562500772899 1.0 10.904179164047695 -7.243728493209427 24.634143187358603 0.97264806361797 0.8695960261601036 0.18605111288367437 0.10633876144142487 1188.3628877716312 1652901.010214011 0.03984397263122162 0.030790558776599992 5.7052083189007485e-08 7.243728493209427 -0.1030520374578664 GDVEGSQS(ph)QDEGEGSGESER ddPTM_A459_Selumetinib_30min_R2 2 GDVEGSQSQDEGEGSGESER 20 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 GDVEGS(0.002)QS(0.985)QDEGEGS(0.008)GES(0.005)ER;GDVEGSQS(1)QDEGEGSGESER 276.05 5.668799999999998e-60 9792700.0 16528.4 14436.199999999999 18367.6 17646.6 17869.0 15706.0 13374.900000000001 15344.400000000001 17104.4 16107.5 True False 15609.817696427584 15543.410120300805 17185.848613130802 15243.102637917054 15624.136469113151 17869.358935127377 13996.859351861567 15389.04966359783 20525.757936866736 15642.434622688974 0.9979148433700928 0.9936694955244029 1.098668399623876 0.9744712383715066 0.9988302234263916 1.1423643036492737 0.894800565863287 0.9838014372312853 1.312184351858797 1.0 13.933177453877926 -8.212429249926597 24.999962384118437 1.1560933083404694 1.011878830109762 0.27370323292490395 0.09480521617113002 406.483556545229 207346.8999529121 0.060155176027380484 0.022736430488633292 6.131556720176531e-09 8.212429249926597 -0.14421447823070732 GDVT(ph)AEEAAGASPAK ddPTM_A459_Selumetinib_30min_R1 1 GDVTAEEAAGASPAK 15 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GDVT(0.532)AEEAAGAS(0.468)PAK 92.269 0.04256 0.0 2365.9 3009.9 3280.7 3204.6 2627.5 2548.7 2819.2 2234.5 1466.0 2196.3 True False 2421.0208667599823 2657.4995087354514 2835.1989595951586 2644.976767792215 2389.8430889228025 2523.0623920344437 2606.545474249058 2175.2338013210765 2487.694927596356 2478.2164987736523 0.9769206475536042 1.072343562416971 1.1440481334048738 1.067290436126579 0.9643399154615501 1.0180960353072395 1.0517827944164317 0.8777416349207153 1.003824697651474 1.0 11.275086512521357 -6.2499218690110885 21.867917953295315 0.984748788030319 1.0713000521763667 0.3156129305090736 0.05682082566657023 166.18925582302913 315535.23500363156 0.01739030832660863 0.022182989541475368 5.62442501323252e-07 6.2499218690110885 0.08655126414604775 GDVTAEEAAGAS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 5 GDVTAEEAAGASPAK 15 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK 244.0 1.6030000000000002e-20 441742200.0 30063.7 35910.9 25289.7 23938.800000000003 24288.7 25719.1 27060.0 30273.0 17208.0 29647.3 True False 30764.125716223047 31706.435133475537 21855.497646378433 19758.337966930125 22091.79137351828 25460.389205074378 25018.842413869017 29470.061699437425 29200.71917740665 33452.81974415703 0.9196272825879319 0.9477955931955027 0.6533230326629127 0.5906329606305064 0.6603865247376314 0.7610835020722391 0.7478844116941408 0.8809440257897768 0.8728926111679101 1.0 15.029840200564454 -8.209790116722255 1.231019639723738 0.985557033644961 0.7466044212060968 0.34038674786311507 0.10804281519247436 0.5634671412836311 1.6499219157924532 0.11446319019416858 0.03721858009853436 6.168930582758163e-09 8.209790116722255 -0.23895261243886412 GDVTAEEAAGAS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 10 GDVTAEEAAGASPAK 15 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVT(0.018)AEEAAGAS(0.982)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK;GDVTAEEAAGAS(1)PAK 189.52 4.7941e-06 590500400.0 869899.0 691453.0 761829.0 773140.0 690071.0 638122.0 916949.0 800737.0 622214.0 680014.0 True False 821553.4960616059 744485.2217281818 712813.7515567007 667836.9982591098 603378.1116669868 726017.5132052305 959588.945399974 803067.0121008544 746674.1861117363 660380.2289314433 1.2440613150865463 1.127358435507417 1.0793989891400892 1.011291630186646 0.9136828833342101 1.0993931698712338 1.453085515525924 1.216067618196704 1.1306731385946014 1.0 19.332937402608124 -7.024428227985163 24.789523070148032 1.2262875171373437 1.0679252223488 0.1575167903775968 0.13174819483606992 1033.0671595745412 1048343.1789847646 0.05114981923305712 0.039836858126774774 9.453046016785718e-08 7.024428227985163 -0.1583622947885437 GDVTAEEAAGAS(ph)PAKANGQENGHVK ddPTM_A459_Selumetinib_30min_R1 2 GDVTAEEAAGASPAKANGQENGHVK 25 1 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GDVTAEEAAGAS(1)PAKANGQENGHVK;GDVTAEEAAGAS(1)PAKANGQENGHVK 77.505 0.00014288 25744000.0 3125.68 2653.7799999999997 4223.4 5062.1 3682.86 3161.54 3280.67 2967.92 2450.3599999999997 2786.22 True False 3198.5022624854582 2343.074203891148 3649.885477475598 4178.099262385623 3349.745963261743 3129.737778048644 3033.2064206174305 2889.2011204371665 4158.0819527865015 3143.8584770810576 1.0173811212568116 0.7452861574311689 1.1609573090148655 1.32897180100321 1.0654887895500447 0.9955084813342094 0.9648037412401709 0.9189984668520035 1.3226046856431999 1.0 11.618320559825786 -5.272820468915329 24.882341823466895 1.0909203984580762 0.881333630375034 0.25205179638470654 0.14688376046843316 878.3119380825955 1920244.7818930573 0.03983131644240598 0.08411269221688938 5.335554140294701e-06 5.272820468915329 -0.20958676808304222 GDVTAEEAAGAS(ph)PAKANGQENGHVK ddPTM_A459_Selumetinib_30min_R2 3 GDVTAEEAAGASPAKANGQENGHVK 25 1 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GDVTAEEAAGAS(1)PAKANGQENGHVK;GDVT(0.001)AEEAAGAS(0.999)PAKANGQENGHVK;GDVT(0.001)AEEAAGAS(0.999)PAKANGQENGHVK 68.634 0.00084006 39394200.0 130754.0 138939.0 131706.0 139445.0 118552.0 84891.0 72876.0 76173.0 49277.0 128725.0 True False 123487.21612973374 149595.17454070176 123232.17935065037 120452.35044395777 103658.43789167296 96583.96468622804 76264.87840105439 76394.650818881 59133.77691441865 125008.37478228375 0.9878315460448208 1.1966812207681181 0.985791388499156 0.9635542470953581 0.8292119473771727 0.7726199532986486 0.6100781530347732 0.6111162628258382 0.47303852255824325 1.0 16.931665224141312 -6.400457136581317 1.1040552471635563 0.6433970360891441 1.0836431197349505 0.5797595275262641 0.13838116032516742 0.31207535803246494 0.8001690615866826 0.060205063747835325 0.0782153298769757 3.976883450525963e-07 6.400457136581317 0.4402460836458064 GDYPLEAVR ddPTM_A459_Selumetinib_30min_R1 2 GDYPLEAVR 9 0 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 185.55 0.012022 65518000.0 6719.6 7667.8 6225.5 6663.299999999999 6868.0 5983.3 7088.9 6391.7 5397.9 5167.9 False True 6876.153605934475 6770.050411336494 5380.1112942236905 5499.679740632172 6246.790612643887 5923.113434401733 6554.178565693869 6222.171352832368 9159.842052982523 5831.250304608823 1.1791902673942491 1.1609946508359752 0.9226342573515378 0.943139027368695 1.0712609279877139 1.01575359056707 1.1239748292940996 1.0670389758290042 1.5708195626147095 1.0 12.509589535988992 -8.052036842526856 24.997310073971732 1.2965833214666502 1.0555583390256285 0.26260695262394684 0.15046181265149527 410.55064696060236 197216.5653160276 0.09627294265268212 0.036388547895164186 8.870807550770429e-09 8.052036842526856 -0.24102498244102177 GEAAAERPGEAAVAS(ph)SPSK ddPTM_A459_Selumetinib_30min_R1 1 GEAAAERPGEAAVASSPSK 19 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEAAAERPGEAAVAS(0.88)S(0.12)PS(0.001)K 174.87 1.8421e-09 9364800.0 2593.6 3016.7 1447.3 1721.1 1798.9 1973.2 2507.5 2495.9 1163.8 2468.4 True False 2654.0258337329096 2663.503361574219 1250.7646094498348 1420.5421940482986 1636.189812621591 1953.3513995222534 2318.3572562001686 2429.7006241742115 1974.8835994110786 2785.2431842520996 0.9528883685054507 0.9562911334399081 0.44906836735898636 0.5100244754497967 0.5874495347022795 0.7013216693488731 0.8323715750596836 0.872347749708843 0.7090524843852654 1.0 11.443587581849597 -7.247190732931915 4.400365517596 0.8445474299312872 0.679293103866528 0.17624607265310055 0.16884680556198078 0.42166232548228494 21.023386489877183 0.07686995817435031 0.055315930151844724 5.6599066334307735e-08 7.247190732931915 -0.1652543260647592 GEAAAERPGEAAVAS(ph)SPSK ddPTM_A459_Selumetinib_30min_R2 3 GEAAAERPGEAAVASSPSK 19 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEAAAERPGEAAVAS(0.613)S(0.383)PS(0.004)K;GEAAAERPGEAAVAS(0.706)S(0.083)PS(0.21)K;GEAAAERPGEAAVAS(0.892)S(0.106)PS(0.002)K 222.93 7.6208999999999985e-19 161790000.0 226900.0 201969.0 204301.0 226760.0 221497.0 206056.0 278755.0 264425.0 214470.0 222533.0 True False 214289.80635266667 217459.37286730832 191156.4960861104 195874.89681718146 193670.56665169625 234438.34360986893 291717.6598425533 265194.4329720846 257369.9927924862 216107.89407982913 0.9915871294988842 1.0062537224437529 0.884541940959816 0.9063754827245056 0.8961753455436262 1.084820823450663 1.3498704482067385 1.2271390367356185 1.1909328619778001 1.0 17.721392246966545 -6.97119809523372 4.697300142621524 1.212745985254328 0.9382365230999373 0.6463837630595108 0.08854694937976201 0.11195441389704842 6.0591300313348935 0.032124868796713175 0.02735891993701154 1.068567361204786e-07 6.97119809523372 -0.27450946215439076 GEAAAERPGEAAVAS(ph)SPSKANGQENGHVK ddPTM_A459_Selumetinib_30min_R2 3 GEAAAERPGEAAVASSPSKANGQENGHVK 29 2 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEAAAERPGEAAVAS(0.555)S(0.414)PS(0.031)KANGQENGHVK;GEAAAERPGEAAVAS(0.386)S(0.307)PS(0.307)KANGQENGHVK;GEAAAERPGEAAVAS(0.386)S(0.307)PS(0.307)KANGQENGHVK 76.79899999999998 2.0346e-05 67762400.0 128106.0 128481.0 137184.0 142969.0 149071.0 97115.0 118716.0 110900.0 77605.0 131115.0 True False 120986.38136894994 138335.0795684716 128357.73079464558 123496.37556471844 130343.36826835133 110491.70972780438 124236.52923129115 111222.7006395168 93128.16846487117 127329.36927231825 0.9501844080464844 1.0864349706517085 1.0080763890389497 0.9698970180288712 1.0236708860906008 0.8677629549196674 0.9757099241227492 0.8735038999654962 0.7313958201245679 1.0 16.95820569820556 -6.92715548913007 1.0251586234281518 0.8665022295135413 1.0179606576981926 0.33482158927989647 0.07795394556188603 0.5565395026403945 1.224466299263787 0.04652506048848711 0.03583753012495765 1.1826180707757078e-07 6.92715548913007 0.15145842818465127 GEAAAERPGEAAVASS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 GEAAAERPGEAAVASSPSK 19 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEAAAERPGEAAVAS(0.312)S(0.533)PS(0.155)K 55.871 0.030656 27295000.0 43421.0 36875.0 43900.0 49466.0 43527.0 45596.0 49424.0 60117.0 37179.0 46167.0 True False 41007.834648035016 39703.19392818697 41075.52179470602 42728.64546639041 38058.74912368283 51876.43512072252 51722.31393179804 60291.93051709492 44615.838868055536 44834.038753728506 0.9146585002812111 0.8855591651306488 0.9161682270101104 0.9530402938066111 0.8488806759689427 1.15707700137562 1.1536394081270827 1.3447802650186385 0.9951331646280734 1.0 15.45230684609234 -6.769052014111379 24.999803798761008 1.1531443774479675 0.9060937883712409 0.579120397721345 0.09551681776525318 111.99150785933914 367776.50929458777 0.03190445823242331 0.02866786807885419 1.7019546583248173e-07 6.769052014111379 -0.2470505890767266 GEAAAERPGEAAVASS(ph)PSKANGQENGHVK ddPTM_A459_Selumetinib_30min_R1 1 GEAAAERPGEAAVASSPSKANGQENGHVK 29 2 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEAAAERPGEAAVAS(0.2)S(0.618)PS(0.182)KANGQENGHVK 69.612 0.00014539999999999998 19831000.0 1950.7 2111.7 2535.1 2295.2 2294.0 1968.3 1809.7 2256.8 1221.7 1895.6 True False 1996.147514598545 1864.4611822973031 2190.8473443075222 1894.386406239996 2086.508105038594 1948.5006890734091 1673.1928720021717 2196.942332880468 2073.135670562395 2138.9187247076156 0.9332507549446102 0.8716839778716556 1.0242779769984038 0.8856747965021221 0.9754966754633531 0.9109746277712183 0.7822610801777392 1.027127542296299 0.9692447153857082 1.0 11.062665948236107 GEAAAERPGEAAVASSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 GEAAAERPGEAAVASSPSK 19 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEAAAERPGEAAVAS(0.117)S(0.196)PS(0.687)K;GEAAAERPGEAAVAS(0.017)S(0.049)PS(0.934)K 124.04 0.00022454 444730000.0 11118.400000000001 14295.9 7798.9 7892.7 9094.2 9180.6 12148.3 12592.8 6680.9 12374.2 True False 11377.43708735965 12622.129382016397 6739.852216291245 6514.388109328341 8271.631215711413 9088.251499317857 11231.94395034756 12258.798036820775 11336.999346370054 13962.54910491506 0.8148538638517371 0.9039989250654229 0.4827092936717909 0.46656151827141384 0.5924155505959621 0.6509020259143536 0.804433622109427 0.8779770760129656 0.8119577063746356 1.0 13.769274734083849 -7.413206440462855 2.5487978127500455 0.8839332304453484 0.6431829144921196 0.41189915123459653 0.1326386082251958 0.3461120486016915 4.381717500232124 0.07539867284743552 0.044840543323866965 3.8618336241780026e-08 7.413206440462855 -0.24075031595322882 GEAEQS(ph)EEEADEEDKAEDAR ddPTM_A459_Selumetinib_30min_R1 2 GEAEQSEEEADEEDKAEDAR 20 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GEAEQS(1)EEEADEEDKAEDAR;GEAEQS(1)EEEADEEDKAEDAR 149.74 8.618e-06 67893000.0 7657.200000000001 5900.1 2014.01 1663.79 2726.0 2980.7 5660.8 8090.7 5152.4 11250.4 True False 7835.597861682467 5209.313549117926 1740.5185041650407 1373.2403097063623 2479.433781314391 2950.716864259063 5233.801298463773 7876.1083537025825 8743.246483593095 12694.498428176066 0.6172435961936842 0.41035993494280937 0.13710809560635132 0.1081760195155397 0.19531561607910128 0.2324406025928367 0.4122889398171961 0.620434781119132 0.6887429647623594 1.0 13.631915773394402 -8.152589866910928 1.0860823769045629 0.9695482053616172 0.26917625505222287 0.716968667778921 0.14529191226912638 0.27541481615716346 0.6277170344268002 0.14910647260781676 0.05117641249146447 7.037365913236625e-09 8.152589866910928 -0.7003719503093944 GEAEQS(ph)EEEADEEDKAEDAR ddPTM_A459_Selumetinib_30min_R2 4 GEAEQSEEEADEEDKAEDAR 20 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GEAEQS(1)EEEADEEDKAEDAR;GEAEQS(1)EEEADEEDKAEDAR;GEAEQS(1)EEEADEEDKAEDAR;GEAEQS(1)EEEADEEDKAEDAR 135.68 7.2522e-05 477168000.0 172989.0 81041.3 107089.0 169042.0 134883.0 169583.0 345957.0 326306.0 286933.0 82526.0 True False 163374.96390983457 87256.90712114917 100199.01032968708 146018.18798628484 117937.7916706805 192941.5189287984 362044.6860007904 327255.4964371341 344327.61757787404 80143.25995170124 2.0385365407932414 1.088761639765278 1.2502487469323378 1.82196466769986 1.471587152079368 2.407457832949092 4.517468920268261 4.083381392700476 4.29640144143606 1.0 16.29029357437554 -7.025298838018024 3.99692609438646 3.7247286751519555 1.526114820272701 0.4678350254227529 0.9578870364955371 0.16603751446059864 5.899010452408515 0.35020050197438723 0.2817524549755667 9.434114914759554e-08 7.025298838018024 -2.1986138548792544 GEAEQS(ph)EEEADEEDKAEDAREEEYEPEK ddPTM_A459_Selumetinib_30min_R1 1 GEAEQSEEEADEEDKAEDAREEEYEPEK 28 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GEAEQS(0.981)EEEADEEDKAEDAREEEY(0.019)EPEK 43.055 0.025867 35886000.0 5455.9 5386.2 2334.0 1689.2 2349.3 2981.2 4766.0 5373.8 3808.7 6958.2 True False 5583.011854666635 4755.581200023553 2017.0556197442943 1394.2129302111375 2136.8062298026025 2951.2118347130263 4406.496782871385 5231.269367437548 6463.085723558146 7851.352748607584 0.7110891630307615 0.6057021448777655 0.2569054893250101 0.1775761419531682 0.27215771577471914 0.3758857778026106 0.5612404542201808 0.6662889230604624 0.8231811676916895 1.0 12.938725529185119 -8.03875750785041 1.2038460070598294 0.975883493340506 0.3886429983469055 0.6369835142274038 0.15381041756877886 0.3297159691898273 0.8726350923152363 0.15997780205830464 0.054878801667968984 9.14623787171461e-09 8.03875750785041 -0.5872404949936004 GEAEQS(ph)EEEADEEDKAEDAREEEYEPEK ddPTM_A459_Selumetinib_30min_R2 2 GEAEQSEEEADEEDKAEDAREEEYEPEK 28 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GEAEQS(0.983)EEEADEEDKAEDAREEEY(0.017)EPEK;GEAEQS(0.99)EEEADEEDKAEDAREEEY(0.01)EPEK 58.919 0.0020852 237010000.0 244250.0 125699.0 146546.0 182552.0 158078.0 189975.0 370800.0 330830.0 256040.0 118370.0 True False 230675.56281021985 135339.70911401117 137117.3899072209 157688.10268023468 138218.82840474942 216142.331828653 388042.93472626107 331792.66052814544 307255.15435533354 114952.35053780512 2.006705924072045 1.1773548646967522 1.1928193661609923 1.37176927607387 1.2024010623366288 1.8802776177905896 3.3756850809122243 2.8863495089561186 2.6728914451756647 1.0 16.810676440924084 -7.025777596815581 6.021243331951869 2.644910285873668 1.3793094368312409 0.4014543818034032 0.616610053218249 0.15110981936064916 18.41907294290968 0.2209247646400481 0.17748695149866092 9.423720638368957e-08 7.025777596815581 -1.2656008490424273 GEAEQS(ph)EEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDK ddPTM_A459_Selumetinib_30min_R1 1 GEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDK 41 3 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GEAEQS(0.89)EEEADEEDKAEDAREEEY(0.055)EPEKMEAEDY(0.055)VMAVVDK 43.469 0.006611 91319000.0 969.19 1011.2 812.25 691.49 615.98 898.14 735.42 917.79 736.67 1072.0 True False 991.7702412845467 892.8082339058737 701.9509113698806 570.7342523749103 560.2647177601019 889.1055270458729 679.9466773099615 893.4472277979282 1250.0751857519842 1209.6016421642557 0.8199147609538968 0.7381010431735479 0.5803157724835168 0.4718365389730584 0.4631811814984472 0.7350399470813039 0.5621244661121495 0.7386293112163319 1.0334602253972738 1.0 10.240316287948641 -8.138507395517385 3.220515595104822 1.0212220474038445 0.6198736696387179 0.663446877166517 0.10994826798014322 0.16525725066338012 3.039245444107777 0.09758778309945138 0.03162021874867279 7.269300203569133e-09 8.138507395517385 -0.40134837776512655 GEAGT(ph)PVAAGTTAAAIPR ddPTM_A459_Selumetinib_30min_R2 1 GEAGTPVAAGTTAAAIPR 18 0 Q9Y6R0;A0A0C4DGH3;M0QXQ4 Q9Y6R0;M0QXQ4 NUMBL Numb-like protein 1 GEAGT(0.999)PVAAGTTAAAIPR 102.58 0.0053001 4059100.0 27410.0 27464.0 26669.0 28421.0 29915.0 25963.0 26543.0 25524.0 25417.0 23056.0 True False 25886.66193092374 29570.400489321386 24953.145575011713 24550.010771040354 26156.81025650681 29539.167581351845 27777.302093956707 25598.27061427433 30501.110210316758 22390.31337331785 1.1561545164335407 1.3206782770874443 1.1144616495072348 1.0964567740394457 1.1682199270903206 1.3192833476173298 1.240594610304045 1.143274334193971 1.3622457936057475 1.0 14.450587099743881 GEASSLNGES(ph)H ddPTM_A459_Selumetinib_30min_R2 2 GEASSLNGESH 11 0 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 GEASSLNGES(1)H;GEASSLNGES(1)H 135.1 0.0015257 10433200.0 59188.0 54207.0 59815.0 68125.0 73428.0 52631.0 52487.0 55425.0 48405.0 59326.0 True False 55898.56790833686 58364.502597023195 55966.56802164783 58846.257477820065 64203.31818535119 59880.442513350885 54927.74950101741 55586.27757389732 58087.35254870293 57613.104232540536 0.9702405147744966 1.0130421433542243 0.9714208037767434 1.0214040410025855 1.1143874130824638 1.039354558498685 0.9533898621278176 0.9648200407590876 1.0082316049877857 1.0 15.814109372833327 -10.330967059625715 10.746930687829066 1.0000014981334913 1.007255641461567 0.001301267657678018 0.0448316047807043 0.0 0.0 0.047865895397879825 0.01160918485824852 4.6669477684422785e-11 10.330967059625715 0.007254143328075724 GECSGPATVNNSSDT(ph)ESIPSPHTEAAK ddPTM_A459_Selumetinib_30min_R1 1 GECSGPATVNNSSDTESIPSPHTEAAK 27 0 Q9Y618 Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 GECSGPATVNNSSDT(0.588)ES(0.102)IPS(0.308)PHT(0.002)EAAK 161.56 4.0636e-17 7963000.0 2053.2 2460.1 2171.9 2045.5 2541.9 1852.1 2248.4 1965.2 1056.2 1813.0 True False 2101.0355651682657 2172.0703483305374 1876.9679093927296 1688.2918237904817 2311.985593808894 1833.4695555722515 2078.8013778027744 1913.0765121307572 1792.2942582041426 2045.7162101154825 1.0270415587358819 1.0617652329244252 0.9175113831095727 0.825281539757255 1.1301594924930376 0.8962482413280337 1.0161729019517445 0.9351622197991785 0.8761206707664334 1.0 10.998390307235027 -7.913419006697376 8.946583740638513 0.9273485735923233 0.9789049016046488 0.04963551197826799 0.08692248732895033 0.8541332091744641 78.7318364280216 0.047410112115493376 0.022714905652896453 1.2206214380584113e-08 7.913419006697376 0.05155632801232557 GECSGPATVNNSSDT(ph)ESIPSPHTEAAK ddPTM_A459_Selumetinib_30min_R2 1 GECSGPATVNNSSDTESIPSPHTEAAK 27 0 Q9Y618 Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 GECSGPATVNNS(0.006)S(0.015)DT(0.714)ES(0.26)IPS(0.005)PHTEAAK 102.46 8.0818e-07 12297000.0 27286.0 26330.0 29406.0 34512.0 34701.0 23425.0 25040.0 26979.0 25353.0 35376.0 True False 25769.553354512413 28349.426335706117 27514.049974831996 29811.40606347927 30341.55014912396 26651.58111902195 26204.409615818688 27057.504423386115 30424.30842200734 34354.60296211364 0.7501048224289233 0.8252002320320788 0.8008839457459186 0.867755802515179 0.8831873324976194 0.7757790462143718 0.7627626971767653 0.7875947352156919 0.885596275281055 1.0 15.06821578938536 -8.570130012528894 3.351568184765272 0.9997484347295466 0.8096110937127234 0.6845526745378332 0.04073674943065239 0.16318996661797103 4.9879571249310235 0.04258526287574838 0.011261093970783563 2.6907291734448273e-09 8.570130012528894 -0.1901373410168231 GECSGPATVNNSSDTES(ph)IPSPHTEAAK ddPTM_A459_Selumetinib_30min_R2 1 GECSGPATVNNSSDTESIPSPHTEAAK 27 0 Q9Y618 Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 GECSGPATVNNSS(0.001)DT(0.088)ES(0.605)IPS(0.304)PHT(0.001)EAAK 191.5 1.4342e-32 12934000.0 39084.0 38348.0 45781.0 58004.0 55277.0 38777.0 36394.0 42146.0 32254.0 43862.0 True False 36911.86774564844 41289.16829174545 42835.50030258397 50103.755137518914 48332.60907735003 44118.179767441376 38086.39311334287 42268.63788235409 38705.70125205795 42595.59009283773 0.8665654746230411 0.9693296466079021 1.0056322781119678 1.1762662526406378 1.1346857496752218 1.0357452419671882 0.8941393470622898 0.992324270898207 0.908678601885742 1.0 15.37841645599779 -7.21512541756696 13.899266020627609 0.9481502065551265 1.0386721321552115 0.18062696614231766 0.08531995656072447 5.528965497242714 1657.8739764939287 0.035962233787382364 0.027846284665664633 6.093608977730665e-08 7.21512541756696 0.09052192560008498 GECSGPATVNNSSDTESIPS(ph)PHTEAAK ddPTM_A459_Selumetinib_30min_R1 1 GECSGPATVNNSSDTESIPSPHTEAAK 27 0 Q9Y618 Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 GECSGPATVNNSSDT(0.009)ES(0.017)IPS(0.974)PHTEAAK 180.21 2.2006e-26 6390000.0 1241.2 1288.2 1030.8 1305.4 1423.0 1240.4 1441.7 1068.6 578.01 1159.0 True False 1270.1175450452229 1137.3769451320677 890.8230217790991 1077.4363953928598 1294.2899012510552 1227.922702193089 1332.9514082806713 1040.2572566980089 980.8407538198985 1307.7689396160197 0.9712094442449047 0.8697078747458388 0.681177687276055 0.8238736696936778 0.9896931040670517 0.9389446904539768 1.0192560534982928 0.7954442296231962 0.7500107428059026 1.0 10.35289194849734 -4.761182604567676 22.96586968169269 0.8703973041938533 0.9712093967540038 0.0670270698449229 0.10768746136288464 7.0888860635490625 630321.4656220376 0.02859757317351852 0.16147714689885792 1.733075151331658e-05 4.761182604567676 0.10081209256015045 GEDAEES(ph)LEEEEALDPLGIMR ddPTM_A459_Selumetinib_30min_R1 3 GEDAEESLEEEEALDPLGIMR 21 0 H7BZZ1;F6TR53;Q53T59 H7BZZ1 HS1BP3 HCLS1-binding protein 3 1 GEDAEES(1)LEEEEALDPLGIMR;GEDAEES(1)LEEEEALDPLGIMR;GEDAEES(1)LEEEEALDPLGIMR 173.45 5.3805e-11 10976300.0 4751.9 4772.47 3928.6699999999996 3565.65 5074.9 4107.91 5012.74 5318.38 3343.28 5128.43 True False 4862.610024412172 4213.706993738889 3395.178192639593 2942.9761630401026 4615.8761910463645 4066.588155083854 4634.624986019875 5177.319285867078 5673.301976490011 5786.713945638465 0.8403059266610535 0.7281692223467905 0.5867195483541382 0.5085746747959209 0.797667939768376 0.7027456676252165 0.8009079124280998 0.8946907233541936 0.9804013175329093 1.0 12.498528613855992 -7.711047417152792 1.1287453903996982 1.0039552710411979 0.6772898994349371 0.6495600593021309 0.08891979866475608 0.33405441296181526 0.7735154867960317 0.08092030020730474 0.03290209331869024 1.9451476948561026e-08 7.711047417152792 -0.32666537160626075 GEDAEES(ph)LEEEEALDPLGIMR ddPTM_A459_Selumetinib_30min_R2 1 GEDAEESLEEEEALDPLGIMR 21 0 H7BZZ1;F6TR53;Q53T59 H7BZZ1 HS1BP3 HCLS1-binding protein 3 1 GEDAEES(1)LEEEEALDPLGIMR 154.13 1.3257e-07 0.0 2641.5 2129.6 2151.2 2281.1 3937.4 3119.6 2726.9 2825.2 2661.2 2734.2 True False 2494.696004762314 2292.9334722567305 2012.7941340494667 1970.4102448830138 3442.74861119739 3549.296583090752 2853.706253249842 2833.4208642629637 3193.5143601406526 2655.2565416952466 0.9395310643579384 0.8635449856731391 0.7580413050274983 0.7420790473319037 1.2965785253274886 1.3367057108631417 1.0747384324031815 1.0670987227674686 1.2027140541763832 1.0 11.374635540626166 -6.256966410570184 24.987531405653538 1.1706024623130273 0.8236553830558595 0.6951756777421783 0.10930592364270181 225.16660624119788 1257856.8467030632 0.034835718715647696 0.043434851503200526 5.533929083629092e-07 6.256966410570184 -0.34694707925716783 GEDLQSIS(ph)PGSR ddPTM_A459_Selumetinib_30min_R2 1 GEDLQSISPGSR 12 0 Q13077 Q13077 TRAF1 TNF receptor-associated factor 1 1 GEDLQS(0.003)IS(0.928)PGS(0.069)R 99.161 0.015818000000000002 0.0 78414.0 86916.0 81383.0 105270.0 102430.0 97128.0 87560.0 105050.0 90104.0 135910.0 True False 74056.06379611284 93582.17772101167 76146.90638311078 90932.0443991209 89561.82766418155 110506.50035980198 91631.71349684842 105355.67810803621 108127.31771611063 131985.9251634121 0.5610906140516411 0.7090314941168716 0.576932019750084 0.6889525855619659 0.6785710487939894 0.8372597322251113 0.6942536742716996 0.7982341903320002 0.8192336992163213 1.0 17.01002456478117 -11.478972001536713 0.05225398178162454 1.9913961804638332 4.162105193035809e-10 0.800570723865746 0.055531158622404854 107.29763820687022 0.7898749523735723 22.43165385961876 9.662553484475247 3.3191585509441254e-12 11.478972001536713 -1.9913961800476225 GEDS(ph)AEETEAK ddPTM_A459_Selumetinib_30min_R2 2 GEDSAEETEAK 11 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 GEDS(0.975)AEET(0.025)EAK;GEDS(1)AEETEAK 196.02 2.0556e-05 10897800.0 40211.0 24893.0 30765.0 43136.0 41857.0 36228.0 60897.0 63949.0 50673.0 27013.0 True False 37976.233597386854 26802.213056389355 28785.61339439931 37260.802386249496 36598.54945367224 41218.078154959534 63728.83116511625 64135.08100267318 60809.01592191769 26233.06450179714 1.4476476278547339 1.0216958470312618 1.0973027338238468 1.4203755105964415 1.3951305403592857 1.5712261963193748 2.4293323092599572 2.4448184846371834 2.3180294440152758 1.0 14.679098730167992 -7.035723717610361 3.2102858853774743 2.1652749223574124 1.263964287945555 0.42347751408698653 0.4131249256687654 0.20566158469726015 4.293690092104273 0.15886139784937975 0.12596984473928785 9.21035314663736e-08 7.035723717610361 -0.9013106344118573 GEDVPS(ph)EEEEEEENGFEDR ddPTM_A459_Selumetinib_30min_R1 2 GEDVPSEEEEEEENGFEDR 19 0 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 GEDVPS(1)EEEEEEENGFEDR;GEDVPS(1)EEEEEEENGFEDR 300.56 2.9426999999999996e-100 45511000.0 14481.4 17258.3 7468.2 6286.4 12550.599999999999 10644.099999999999 18234.6 17993.0 8229.9 16928.0 True False 14818.788444100777 15237.690212833997 6454.059459886178 5188.598250342939 11415.4004459884 10537.030018069543 16859.149441239315 17515.76719049904 13965.53921188626 19100.873692683334 0.7758173098530657 0.7977483364371367 0.33789341596235106 0.2716419329200869 0.5976376070358036 0.5516517300517931 0.8826376066607509 0.9170139268136475 0.7311466185568158 1.0 14.221351009604895 -7.258731111704257 12.635461588703537 0.875806355827233 0.5455324001051827 0.48186570164796527 0.1660185342922398 0.28608077696728773 1298.2158127706157 0.07251848526127849 0.0530457805742548 5.5114882807381174e-08 7.258731111704257 -0.3302739557220503 GEDVPS(ph)EEEEEEENGFEDR ddPTM_A459_Selumetinib_30min_R2 4 GEDVPSEEEEEEENGFEDR 19 0 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 GEDVPS(1)EEEEEEENGFEDR;GEDVPS(1)EEEEEEENGFEDR;GEDVPS(1)EEEEEEENGFEDR;GEDVPS(1)EEEEEEENGFEDR 200.33 1.9657e-15 381391000.0 195735.0 140395.0 191774.0 217494.0 232026.0 200423.0 219069.0 241011.0 219714.0 173824.0 True False 184856.83228928703 151162.84505892344 179435.46962774385 187870.94200192273 202876.81954124197 228029.44899115208 229256.14257698858 241712.3021084808 263662.93932208914 168805.24947101 1.0950893581128451 0.8954866364205315 1.062973279504317 1.1129449030208447 1.201839517295837 1.35084335176622 1.358110267870314 1.4319003873750478 1.5619356634247896 1.0 17.365000243813867 -6.35976220912342 1.2835018623861496 1.3773558831834303 1.000074957543422 0.4925476015996417 0.14284752392810876 0.32659463218176726 1.1017398837674564 0.05619206763407392 0.0732865831856953 4.3675490482515567e-07 6.35976220912342 -0.37728092564000826 GEEDWLYER ddPTM_A459_Selumetinib_30min_R2 2 GEEDWLYER 9 0 J3QQZ9;Q9NVS9-4;Q9NVS9-3;Q9NVS9 J3QQZ9 PNPO Pyridoxine-5-phosphate oxidase 0 ; 141.48 0.030512 4499400.0 39067.0 31360.0 36707.0 35359.0 39563.0 32861.0 32217.0 37977.0 28841.0 30709.0 False True 36895.81253759204 33765.21116170694 34345.31158355977 30543.04320232277 34592.74224229244 37387.30446754235 33715.1543367744 38087.506782569195 34610.00588487021 29822.35137843586 1.2371865675310536 1.1322115661919976 1.151663433500901 1.0241661636516037 1.159960252742042 1.2536672240598912 1.1305330659189194 1.2771463356209316 1.1605391354182837 1.0 14.864106392645967 -4.753085394194388 24.741021583577204 1.1520874371633871 1.2371867489870063 0.09823066734551444 0.08151432877468454 745.4157932904141 2207415.0979469554 0.02023674954398703 0.22231257363069082 1.7656906034002366e-05 4.753085394194388 0.08509931182361918 GEEGS(ph)DDDETENGPK ddPTM_A459_Selumetinib_30min_R2 1 GEEGSDDDETENGPK 15 0 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 1 GEEGS(1)DDDETENGPK 220.52 2.0541e-09 4612700.0 16191.0 12259.0 14682.0 12637.0 13896.0 12877.0 17322.0 16628.0 14694.0 12617.0 True False 15291.169037708361 13199.225881102207 13737.376104552937 10915.818799959074 12150.2602481838 14650.689864232476 18127.50732289184 16676.384727086406 17633.2105846636 12252.714427097118 1.247982161723417 1.0772491238277666 1.1211700220624141 0.8908898403621099 0.991638246404671 1.1957097303951023 1.4794686867754383 1.3610359423872846 1.439126871811148 1.0 13.580813774222255 -7.0074073471675655 5.422123496879517 1.3497915108501952 1.0616014372092077 0.3886064035972179 0.14834842459910033 0.15678910971865095 15.22903950527611 0.05429547996241896 0.04475452685343679 9.830885837610967e-08 7.0074073471675655 -0.2881900736409875 GEEGS(ph)DDDETENGPKPK ddPTM_A459_Selumetinib_30min_R1 5 GEEGSDDDETENGPKPK 17 1 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 1 GEEGS(1)DDDETENGPKPK;GEEGS(0.987)DDDET(0.013)ENGPKPK;GEEGS(0.955)DDDET(0.045)ENGPKPK;GEEGS(0.994)DDDET(0.006)ENGPKPK;GEEGS(0.999)DDDET(0.001)ENGPKPK 203.2 1.3681e-07 269077300.0 15029.800000000001 17064.7 15430.699999999999 16731.3 13646.8 14720.9 15464.9 14841.7 8996.679999999998 14957.880000000001 True False 15379.965097100136 15066.756990836197 13335.295694767901 13809.492540398769 12412.449349538221 14572.821111507781 14298.370142137583 14448.04990336407 15266.708868490849 16877.869600089438 0.9112503806178616 0.8926930559267003 0.7901053871572296 0.8182011632751085 0.7354274943250211 0.863427758171005 0.8471667622116131 0.8560351659126166 0.9045400414996658 1.0 14.042845191689663 -8.613385478895934 1.150284853283206 0.9998144452686244 0.8321862300341353 0.5320858591640107 0.0471873326027687 0.5059093964787538 1.4286662325041937 0.04838056041278124 0.01520967986675718 2.435647982467228e-09 8.613385478895934 -0.16762821523448912 GEEGS(ph)DDDETENGPKPK ddPTM_A459_Selumetinib_30min_R2 6 GEEGSDDDETENGPKPK 17 1 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 1 GEEGS(1)DDDETENGPKPK;GEEGS(1)DDDETENGPKPK;GEEGS(0.992)DDDET(0.008)ENGPKPK;GEEGS(1)DDDETENGPKPK;GEEGS(1)DDDETENGPKPK;GEEGS(0.999)DDDET(0.001)ENGPKPK 167.92 5.928300000000001e-06 489102600.0 618668.0 525605.0 564306.0 536709.0 559769.0 453733.0 508459.0 572103.0 394834.0 520552.0 True False 584284.9092842296 565917.213413552 527999.1663299169 463608.30832533294 489445.8138216462 516230.60217191814 532103.3509923945 573767.7250132497 473811.83258371305 505522.3112034774 1.1558043954444763 1.119470300067063 1.044462637213637 0.917087728970139 0.9681982436273515 1.0211826278111207 1.0525813385479201 1.1349998057401325 0.937271851475215 1.0 18.947415241248166 -5.271993710987119 3.207194976241057 1.009776222808486 1.1451868509009608 0.44813093271434457 0.058239013406288405 0.24452989758051652 5.174080114298433 0.016711970973205637 0.046873946553504735 5.345721004727251e-06 5.271993710987119 0.13541062809247495 GEEHCGHLIEAHK ddPTM_A459_Selumetinib_30min_R2 2 GEEHCGHLIEAHK 13 0 H7C4E5;C9J8T6;Q14061 H7C4E5 COX17 Cytochrome c oxidase copper chaperone 0 ; 90.614 0.007340999999999999 5436200.0 27943.0 20899.0 26914.0 30533.0 27599.0 26461.0 30138.0 25359.0 25363.0 25019.0 False True 26390.03992469179 22501.886099123516 25182.38254174754 26374.352727637142 24131.76688180952 30105.762560957945 31539.476717314043 25432.79049159156 30436.308701430717 24296.636462831335 1.0861602166646778 0.926131735705335 1.0364555019898003 1.085514563630413 0.9932143043225744 1.2390917815728664 1.2981005319630439 1.0467617824589959 1.2526963865139016 1.0 14.568468985797676 -6.754615430999625 24.9995375963317 1.1784258639078558 1.0239183598701331 0.35302153403394465 0.09540441416848375 166.47323493113137 609874.2130365726 0.03080840757384334 0.030144281461651597 1.7594809497353976e-07 6.754615430999625 -0.15450750403772262 GEELSCEER ddPTM_A459_Selumetinib_30min_R1 2 GEELSCEER 9 0 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 0 ; 163.15 0.0132 28278000.0 6004.299999999999 6664.200000000001 4818.5 4941.3 5864.7 5193.2 5997.299999999999 5541.4 3316.5 4956.9 False True 6144.188507665986 5883.9523658974695 4164.17416612591 4078.394714688784 5334.238920496881 5140.961123048331 5544.91883254607 5394.42407099602 5627.858272423821 5593.166399294781 1.0985170239956892 1.0519895075246382 0.7445110459526028 0.7291745718852585 0.9537064588619165 0.9191503981888566 0.9913738366956517 0.9644669380256917 1.0062025462238018 1.0 12.449449536470715 -7.1455195590371305 2.1325782222463263 0.9897332838874597 0.9037406580401873 0.09515590470734359 0.10921655855424738 0.8824515320871376 7.872896601441654 0.0571665384656819 0.04029971374455352 7.152871794280742e-08 7.1455195590371305 -0.08599262584727241 GEES(ph)EVTVGGLEPGR ddPTM_A459_Selumetinib_30min_R2 1 GEESEVTVGGLEPGR 15 0 A0A087X0I0;A0A140T9L7;A0A140T8Z8;A0A140T9C0;A0A140T902;A0A140T8Y3;A0A140TA52;A0A140TA41;A0A140TA33;A0A3B3ISX9;P22105-1;P22105;P22105-4 A0A087X0I0 TNXB Tenascin-X 1 GEES(0.986)EVT(0.014)VGGLEPGR 79.88600000000002 0.03023 7372700.0 34575.0 29554.0 30004.0 33187.0 34493.0 26316.0 20559.0 27140.0 25235.0 32468.0 True False 32653.459914691266 31820.6967689122 28073.575305885173 28666.873349231766 30159.680968667537 29940.790127136876 21515.034236885644 27218.972906731127 30282.70512481189 31530.564478005024 1.0356129189336127 1.0092016205770615 0.8903606951112034 0.909177295865702 0.9565220752614885 0.9495798956603794 0.6823548703637711 0.8632567591905448 0.9604238181633694 1.0 14.94446337774478 -7.046495797019326 24.996523573536514 0.8580926995641384 0.9558735356625421 0.16035604711148554 0.08786064958842077 671.3507681982206 360921.6650863503 0.03403046313560111 0.02636078669242583 8.984712876827415e-08 7.046495797019326 0.09778083609840371 GEETVLGGGTR ddPTM_A459_Selumetinib_30min_R1 1 GEETVLGGGTR 11 0 Q5T3I0;Q5T3I0-3 Q5T3I0 GPATCH4 G patch domain-containing protein 4 0 157.68 0.0078032 35501000.0 3023.4 3271.1 3328.2 3592.1 3042.8 2716.1 3093.8 2960.3 1794.8 2604.3 False True 3093.839337487695 2888.1180913068665 2876.248720493984 2964.807167068095 2767.579277249972 2688.7785000214853 2860.43217516733 2881.7832275904143 3045.6445129945055 2938.587273030198 1.0528322115468107 0.9828253589108861 0.9787862170681996 1.008922618796637 0.9418060517209391 0.9149901807234344 0.973403853416177 0.9806696074807372 1.0364315332564251 1.0 11.520907030189075 -11.463963416691444 2.599874274240107 1.0125383445699836 0.9821590229626181 0.005174956941725095 0.038583936783554144 70586125.20344375 36412440.85401562 5359031.238986446 0.00999080903169333 3.4358688912826745e-12 11.463963416691444 -0.03037932160736545 GEFS(ph)ASPMLK ddPTM_A459_Selumetinib_30min_R2 1 GEFSASPMLK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEFS(0.69)AS(0.31)PMLK 101.39 0.016405 4803500.0 20398.0 23434.0 24119.0 21781.0 20349.0 18886.0 18481.0 18260.0 19138.0 22433.0 True False 19264.360819663703 25231.312447813794 22567.209798781645 18814.390225679264 17792.576697631866 21487.37506996152 19340.403119406757 18313.13357689426 22966.134760398254 21785.30100206624 0.8842825177323261 1.158180575307209 1.0358915764643897 0.863627737982358 0.8167239321570227 0.9863244518826495 0.8877730501668261 0.8406187995822201 1.054203233557343 1.0 14.411067426297516 -5.746074081049801 24.14136956351482 0.911635585577862 1.0393245730582892 0.19767033118881694 0.09424149286164407 208.08175814369622 326925.70506259735 0.02466362161333522 0.04249343439539623 1.7944275110108546e-06 5.746074081049801 0.12768898748042723 GEFSAS(ph)PMLK ddPTM_A459_Selumetinib_30min_R1 6 GEFSASPMLK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEFS(0.047)AS(0.953)PMLK;GEFS(0.204)AS(0.796)PMLK;GEFS(0.034)AS(0.966)PMLK;GEFS(0.107)AS(0.893)PMLK;GEFS(0.027)AS(0.973)PMLK;GEFS(0.044)AS(0.956)PMLK 178.53 9.6856e-05 1493854000.0 26304.3 29932.4 32073.6 34195.5 30701.1 25843.6 29169.2 26415.300000000003 16995.0 24197.9 True False 26917.139010742045 26427.900692804782 27718.181287673764 28223.897854034407 27924.190925719457 25583.636848111342 26968.943759742364 25714.680435013033 28839.273734311126 27303.936172506026 0.9858336483311344 0.9679154143136557 1.0151716262648192 1.0336933721100163 1.0227166789907018 0.93699445700701 0.9877309846226132 0.9417938964018928 1.0562313635698841 1.0 14.736821326563096 GEFSAS(ph)PMLK ddPTM_A459_Selumetinib_30min_R2 5 GEFSASPMLK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEFS(0.013)AS(0.987)PMLK;GEFS(0.004)AS(0.996)PMLK;GEFS(0.146)AS(0.854)PMLK;GEFS(0.027)AS(0.973)PMLK;GEFSAS(1)PMLK 152.7 0.00062384 955975200.0 184971.3 166535.0 199001.9 183696.5 198255.0 143064.6 154496.4 167177.0 133421.1 165837.1 True False 174691.33564478185 179307.69900557597 186198.33441088663 158676.71980586252 173348.43447781226 162770.4500388655 161680.78872880884 167663.45739235796 160109.04809700948 161048.9520264679 1.0847095460520095 1.113373895013656 1.1561598636188923 0.9852701170001062 1.0763710803242172 1.0106892841632071 1.0039232587011004 1.0410713965080816 0.9941638618716132 1.0 17.297139747320614 -5.762990925777351 24.999883636994433 1.0194384145235276 1.1176103854753459 0.7127414529274729 0.02966007426712889 21.648450272086095 348829.52630189003 0.008051611028858109 0.012690804337887827 1.7258739523168935e-06 5.762990925777351 0.09817197095181829 GEGDAPFSEPGT(ph)TSTQRPSSPETATK ddPTM_A459_Selumetinib_30min_R1 1 GEGDAPFSEPGTTSTQRPSSPETATK 26 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEGDAPFS(0.01)EPGT(0.852)T(0.012)S(0.012)T(0.006)QRPS(0.053)S(0.053)PET(0.002)ATK 80.702 0.00019189 119950000.0 3586.5 5574.3 4481.1 4515.6 4854.7 4377.7 5403.4 4373.1 2385.0 4485.0 True False 3670.058471885828 4921.658364578233 3872.591232920376 3727.0352283100915 4415.593242166901 4333.664312633572 4995.817187697704 4257.111182169255 4047.1708064920294 5060.693437599526 0.7252086136295726 0.9725264778956374 0.7652293664239993 0.7364672992478205 0.8725273120399445 0.8563380426159917 0.9871803635802536 0.8412110384992141 0.7997265308391713 1.0 12.305119367297493 -6.491975729727147 18.538544461373025 0.8894795666819074 0.809064939179219 0.2175452166663262 0.0861322028384101 54.56149280082503 32730.093497253078 0.02674634461967475 0.03021520441457189 3.2212488037085394e-07 6.491975729727147 -0.08041462750268846 GEGDAPFSEPGTT(ph)STQRPSSPETATK ddPTM_A459_Selumetinib_30min_R2 1 GEGDAPFSEPGTTSTQRPSSPETATK 26 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEGDAPFS(0.01)EPGT(0.174)T(0.33)S(0.33)T(0.087)QRPS(0.031)S(0.031)PET(0.004)AT(0.002)K 62.858 0.004246100000000001 10970000.0 58251.0 47062.0 58808.0 64684.0 62720.0 48736.0 51541.0 57253.0 47446.0 54760.0 True False 55013.64261722865 50671.504071819254 55024.35730530915 55873.927613876134 54840.55287608583 55448.94161864049 53937.75862655398 57419.59675125564 56936.52575200411 53178.93651643324 1.0345006166159125 0.9528491427458474 1.034702100300664 1.050677792261041 1.0312457613577721 1.0426861695796752 1.014269223114047 1.0797432312982032 1.0706593527760697 1.0 15.698567305714395 -5.469821069263563 12.961104036428177 1.043122559116569 0.9936755076941541 0.29743161531130424 0.028850015647478897 2.0981776146376365 510.6290224831503 0.007275233499785696 0.015128679451841298 3.3898378979433913e-06 5.469821069263563 -0.04944705142241479 GEGDAPFSEPGTTST(ph)QRPSSPETATK ddPTM_A459_Selumetinib_30min_R1 1 GEGDAPFSEPGTTSTQRPSSPETATK 26 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEGDAPFS(0.001)EPGT(0.037)T(0.128)S(0.128)T(0.547)QRPS(0.08)S(0.08)PET(0.001)ATK 87.802 9.2859e-05 245260000.0 3253.6 4399.8 3188.0 3714.4 3711.8 3918.2 4600.3 4188.5 2318.4 3818.2 True False 3329.4025495964684 3884.6693705884736 2755.0871104305093 3065.7497679234234 3376.0683453715174 3878.7864654409577 4253.295667277221 4077.4073738345623 3934.1554707635696 4308.303162417505 0.77278743488614 0.9016703848688032 0.6394831112313266 0.7115910028492862 0.7836190300677714 0.9003049040923263 0.9872322134569987 0.9464067917510752 0.9131566007430195 1.0 12.072904056254448 -6.826325157185595 2.961430212374709 0.9563310593923248 0.7572168410759247 0.6838245159787724 0.06493040304323185 0.16411553498419085 2.9219506058319915 0.025752157440473544 0.02305407149309154 1.4916771695790967e-07 6.826325157185595 -0.19911421831640008 GEGDAPFSEPGTTST(ph)QRPSSPETATK ddPTM_A459_Selumetinib_30min_R2 1 GEGDAPFSEPGTTSTQRPSSPETATK 26 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEGDAPFS(0.003)EPGT(0.038)T(0.15)S(0.15)T(0.45)QRPS(0.095)S(0.095)PET(0.016)AT(0.003)K 56.335 0.013711 87588000.0 98511.0 83542.0 83248.0 99699.0 119450.0 118520.0 89288.0 92039.0 83621.0 103290.0 True False 93036.15299077818 89949.40277013156 77891.91431356905 86119.82420963218 104443.62310345116 134845.05418256047 93440.0689208154 92306.81825212321 100347.53656595574 100307.74932035056 0.9275071330097414 0.8967343338834393 0.7765293792487301 0.8585560417131209 1.0412318471017823 1.3443134263925005 0.9315338999621854 0.9202361619870967 1.0003966517629472 1.0 16.61407354074757 -6.264546869954074 9.969860533247626 1.045513136134413 0.8607462656177474 0.3512119870901148 0.11616367834461042 0.15046133779112586 320.4222587180498 0.03823102038634839 0.04581802436553495 5.438174386564096e-07 6.264546869954074 -0.18476687051666563 GEGDAPFSEPGTTSTQRPS(ph)SPETATK ddPTM_A459_Selumetinib_30min_R1 2 GEGDAPFSEPGTTSTQRPSSPETATK 26 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEGDAPFSEPGT(0.035)T(0.035)S(0.009)T(0.009)QRPS(0.456)S(0.456)PET(0.001)ATK;GEGDAPFS(0.003)EPGT(0.03)T(0.135)S(0.135)T(0.135)QRPS(0.255)S(0.255)PET(0.05)AT(0.003)K 90.592 2.2325e-05 356260000.0 5120.4 7600.8 5895.5 5664.4 6900.200000000001 5980.6 7130.9 6769.0 3485.3 6200.4 True False 5239.695357435995 6710.894802483947 5094.923481663448 4675.218873956878 6276.078128329257 5920.4405939503295 6593.010471879475 6589.464131189241 5914.299543759611 6996.281737010496 0.7489257228904723 0.9592087704220308 0.7282330348006402 0.6682433683630634 0.8970590899918531 0.8462267267813214 0.9423592016030877 0.9418523122547824 0.845348967648462 1.0 12.772372671749523 -6.479939236112568 22.948337679085846 0.9086033308438016 0.7854109197400541 0.3968412623066825 0.08186859472612053 217.8475446267431 116424.72641364425 0.026076116491101035 0.029563426419388122 3.3117745461065803e-07 6.479939236112568 -0.12319241110374757 GEGDAPFSEPGTTSTQRPS(ph)SPETATK ddPTM_A459_Selumetinib_30min_R2 6 GEGDAPFSEPGTTSTQRPSSPETATK 26 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GEGDAPFS(0.019)EPGT(0.233)T(0.023)S(0.03)T(0.006)QRPS(0.331)S(0.331)PET(0.025)AT(0.003)K;GEGDAPFS(0.004)EPGT(0.034)T(0.086)S(0.086)T(0.024)QRPS(0.322)S(0.322)PET(0.109)AT(0.014)K;GEGDAPFS(0.01)EPGT(0.024)T(0.045)S(0.144)T(0.161)QRPS(0.304)S(0.304)PET(0.007)AT(0.001)K;GEGDAPFSEPGT(0.033)T(0.163)S(0.163)T(0.163)QRPS(0.235)S(0.235)PET(0.008)AT(0.001)K;GEGDAPFS(0.001)EPGT(0.014)T(0.014)S(0.014)T(0.037)QRPS(0.448)S(0.448)PET(0.019)AT(0.005)K;GEGDAPFSEPGTT(0.011)S(0.031)T(0.103)QRPS(0.415)S(0.415)PET(0.013)AT(0.012)K 83.064 6.2387e-05 705199500.0 146641.0 118783.8 146917.7 156051.7 154004.5 123462.5 151043.5 152725.8 129244.7 133312.6 True False 138491.28027043378 127894.1355098841 137465.17513389682 134797.18925580254 134657.0778923017 140468.33869401255 158067.32203701738 153170.20679288288 155097.25139864392 129463.51885026766 1.069732087466333 0.9878777948079825 1.0618062629124392 1.041198249923236 1.0401160040153141 1.0850032498844144 1.2209410298806396 1.1831148122123378 1.1979996587148478 1.0 16.982186096761758 -7.04063740624274 4.5021337040550415 1.1655423568376475 1.0398535164382412 0.4197653601437322 0.06002450167340192 0.17287835820147376 7.908654856728051 0.021783754460802263 0.017317324913073293 9.106732791570765e-08 7.04063740624274 -0.1256888403994063 GEGDHNHDTGEGGQGGEEPR ddPTM_A459_Selumetinib_30min_R1 1 GEGDHNHDTGEGGQGGEEPR 20 0 Q5TE25;Q9NWM0-5;Q9NWM0;Q9NWM0-6 Q5TE25 SMOX Spermine oxidase 0 71.376 0.0055525 358680.0 0.0 173.73 154.98 132.15 221.63 135.81 219.07 66.08800000000001 91.511 0.0 False True 0.0 153.3896108351142 133.93456724420332 109.07248326272897 201.58360563195455 134.4438747056139 202.5453735257312 64.3351315559218 155.28748330100288 0.0 0.0 GEGDHNHDTGEGGQGGEEPR ddPTM_A459_Selumetinib_30min_R2 1 GEGDHNHDTGEGGQGGEEPR 20 0 Q5TE25;Q9NWM0-5;Q9NWM0;Q9NWM0-6 Q5TE25 SMOX Spermine oxidase 0 58.848 0.0193 868950.0 868.75 1109.0 1498.5 2170.8 1781.2 1536.5 923.0 1115.3 1326.9 1590.9 False True 820.4683528817945 1194.0567340029647 1402.0881414434393 1875.1332951611273 1557.429731869962 1748.1389280417166 965.9213288898026 1118.5453383521458 1592.3170766836881 1544.9665833453917 0.5310589638160291 0.7728689713258492 0.9075200438364365 1.213704759297 1.008066937278076 1.1315059800558183 0.6252053211392093 0.7239932244554473 1.0306482313913652 1.0 10.593359918543673 -4.912808212356343 2.2297504659720007 0.9505068151229686 0.4868628647284781 0.39241368685893885 0.16521863227803474 0.5420684056820779 3.9623018614186023 0.04859177880512132 0.45264341711606565 1.2223393350520475e-05 4.912808212356343 -0.4636439503944905 GEGDIHENVDTDLPGS(ph)LGQSEEKPVPAAPVPSPVAPAPVPSR ddPTM_A459_Selumetinib_30min_R1 2 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSR 42 1 Q9UK76;Q9UK76-3 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 GEGDIHENVDT(0.001)DLPGS(0.564)LGQS(0.435)EEKPVPAAPVPSPVAPAPVPSR;GEGDIHENVDT(0.007)DLPGS(0.875)LGQS(0.119)EEKPVPAAPVPSPVAPAPVPSR 118.81 8.6059e-30 406080000.0 7804.900000000001 11172.0 5998.1 6095.1 7799.5 7397.3 10541.3 9818.2 5583.299999999999 9610.599999999999 True False 7986.738984308294 9863.97704627811 5183.590965204902 5030.705204197196 7094.036602113567 7322.8898782110155 9746.161254150682 9557.789441991761 9474.452311902278 10844.214125171453 0.7364977205466255 0.9096073659576651 0.4780052206063339 0.4639068489545947 0.6541771049731469 0.675280826594268 0.8987429740554472 0.8813722535970901 0.8736873140406088 1.0 13.40463788495253 -7.235158122935473 3.7490523700230463 0.9070356621987888 0.6447723231350535 0.5216387166203118 0.12234853271443435 0.2193022563172304 6.772521029022357 0.056828226724454395 0.040737707882897295 5.818913175068473e-08 7.235158122935473 -0.26226333906373533 GEGDIHENVDTDLPGS(ph)LGQSEEKPVPAAPVPSPVAPAPVPSR ddPTM_A459_Selumetinib_30min_R2 1 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSR 42 1 Q9UK76;Q9UK76-3 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 GEGDIHENVDT(0.005)DLPGS(0.806)LGQS(0.189)EEKPVPAAPVPSPVAPAPVPSR 89.645 2.7274e-12 5320000.0 19553.0 14109.0 23882.0 25107.0 21184.0 19297.0 22336.0 21555.0 21491.0 17049.0 True False 18466.3225368607 15191.114932414639 22345.458120755564 21687.383288009234 18522.676532637142 21954.986589274984 23374.668257944362 21617.721481377663 25789.80050871141 16556.751071378192 1.1153349142745526 0.9175178672991985 1.3496281984564207 1.3098815821118681 1.1187386011170672 1.3260443727531044 1.411790764816919 1.3056741258101305 1.5576607027265437 1.0 14.015131980341618 -5.268312209130966 24.978058737015964 1.3075137382122326 1.0164263857073443 0.3577579977317843 0.15011321426096627 477.25619420903786 1734506.1444714924 0.03787886251112658 0.08174512521638233 5.391229141298776e-06 5.268312209130966 -0.29108735250488826 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPS(ph)PVAPAPVPSR ddPTM_A459_Selumetinib_30min_R1 2 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSR 42 1 Q9UK76;Q9UK76-3 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 GEGDIHENVDTDLPGS(0.339)LGQS(0.089)EEKPVPAAPVPS(0.569)PVAPAPVPS(0.003)R;GEGDIHENVDT(0.004)DLPGS(0.396)LGQS(0.102)EEKPVPAAPVPS(0.495)PVAPAPVPS(0.003)R 85.37 5.1902e-12 55147000.0 5835.299999999999 8231.2 4348.4 4189.9 5138.3 5127.9 7076.7 6427.3 3958.3 7364.9 True False 5971.251136482749 7267.487277418935 3757.911164051452 3458.212619163887 4673.541672240545 5076.317981760675 6542.898821516143 6256.827125187266 6716.945997206459 8310.256655201058 0.7185399181077736 0.8745201958197651 0.4522015769151396 0.41613788390031614 0.5623823506480468 0.610849723706621 0.7873281287192501 0.7529041983644834 0.808271787009441 1.0 13.020677318753725 -8.17199234045006 0.8376284598211599 0.9809617616646673 0.6031553333261249 0.4757171263537352 0.12785359140536504 0.5720852915254573 0.8338116672728754 0.13581480089884812 0.052256652628975185 6.729885255204653e-09 8.17199234045006 -0.3778064283385424 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPS(ph)PVAPAPVPSR ddPTM_A459_Selumetinib_30min_R2 5 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSR 42 1 Q9UK76;Q9UK76-3 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 GEGDIHENVDT(0.057)DLPGS(0.198)LGQS(0.198)EEKPVPAAPVPS(0.538)PVAPAPVPS(0.008)R;GEGDIHENVDTDLPGSLGQS(0.001)EEKPVPAAPVPS(0.974)PVAPAPVPS(0.025)R;GEGDIHENVDTDLPGS(0.021)LGQS(0.005)EEKPVPAAPVPS(0.974)PVAPAPVPS(0.001)R;GEGDIHENVDTDLPGS(0.007)LGQS(0.093)EEKPVPAAPVPS(0.895)PVAPAPVPS(0.005)R;GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPS(0.996)PVAPAPVPS(0.004)R 107.62 7.202e-23 490259900.0 224171.2 205580.2 234476.1 271228.7 253128.0 248455.1 297556.2 285794.0 298990.9 226810.5 True False 211712.6621324147 221347.54029546975 219390.16300427445 234286.8831643954 221327.7976469683 282677.53477416065 311393.15289642464 286625.61322425614 358797.4345037488 220261.89154054926 0.9611860710523287 1.0049288996263823 0.9960423088616112 1.0636741631779922 1.0048392670151152 1.2833701408676088 1.4137404828338112 1.3012946144226207 1.628958291396929 1.0 17.748860384177114 -6.830988399512659 3.696071793736749 1.3600781500892851 1.006516629471723 0.5421588881768852 0.14646759432606213 0.16265434836387052 4.415822891749126 0.05014079018720268 0.044886631926652744 1.4757459515607364e-07 6.830988399512659 -0.3535615206175622 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPS(ph)PVAPAPVPSRR ddPTM_A459_Selumetinib_30min_R1 2 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRR 43 2 Q9UK76;Q9UK76-3 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 GEGDIHENVDTDLPGSLGQSEEKPVPAAPVPS(0.982)PVAPAPVPS(0.018)RR;GEGDIHENVDTDLPGS(0.002)LGQS(0.002)EEKPVPAAPVPS(0.955)PVAPAPVPS(0.04)RR 89.681 1.473e-12 19866100.0 2273.8 1974.83 3394.6 3493.0 3189.4 2457.7 2699.9 2751.1000000000004 1955.29 2252.5 True False 2326.775115955387 1743.6159855264407 2933.631965203074 2883.0131217307 2900.9193331343063 2432.9777694130566 2496.24436929804 2678.1318911677836 3317.9843212686765 2541.630316208011 0.9154655974621919 0.6860226581369359 1.1542323627851236 1.134316467405069 1.1413616349455324 0.9572508456080038 0.9821429786147323 1.0537063057869982 1.3054551246535915 1.0 11.31153848819177 -5.2673252880821515 24.99642800004965 1.0876491254673184 0.8007441224280553 0.5284940407697712 0.10964828242843273 333.58138172109875 1416667.1311728985 0.02898737856338939 0.06299818588199128 5.4034944771646964e-06 5.2673252880821515 -0.28690500303926314 GEGGS(ph)EDGSEDGLPEGIHLDK ddPTM_A459_Selumetinib_30min_R2 1 GEGGSEDGSEDGLPEGIHLDK 21 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 GEGGS(0.936)EDGS(0.064)EDGLPEGIHLDK 133.15 8.2195e-05 0.0 10031.0 5880.8 8192.4 10041.0 12468.0 9405.7 11511.0 12841.0 13867.0 5351.1 True False 9473.517177274573 6331.838450247641 7665.309903210694 8673.398478308869 10901.658374665782 10701.249798556439 12046.284308613782 12878.365184058006 16640.787476352925 5196.599839172498 1.8230222588743965 1.2184579621693399 1.475062567917739 1.6690526010734767 2.0978444967973044 2.0592791690230463 2.3181088945521005 2.4782291464852806 3.2022453125816956 1.0 12.343352254141537 -6.393799977337241 1.3123377643190945 2.3481211146404504 1.4644417151386069 0.2569078966906576 0.5294426358752523 0.5082522501280924 1.7919947325936936 0.21008458159208065 0.2643182328813271 4.0383134242195416e-07 6.393799977337241 -0.8836793995018435 GEGPGEAGGPLT(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 GEGPGEAGGPLTPR 14 0 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 GEGPGEAGGPLT(1)PR;GEGPGEAGGPLT(1)PR;GEGPGEAGGPLT(1)PR 173.33 0.00024828 66569000.0 3302.57 3760.91 3571.8399999999997 3779.25 3776.01 5026.7 9362.2 9652.8 7068.0 2724.82 True False 3379.513455317435 3320.580908800375 3086.8037467127074 3119.27493280869 3434.4705622087104 4976.135961878426 8656.00171644954 9396.77638728668 11993.879773704672 3074.5771889944103 1.0991799026593179 1.08001221133317 1.0039766631204 1.014537850594312 1.1170545903035236 1.6184781373161592 2.8153470166350334 3.056282477123317 3.900985090449937 1.0 11.586172311607843 -7.132988193446701 2.5705769928765765 2.890565677470441 1.060588342837027 0.55414787098321 0.6814085360538599 0.19243926778105996 2.476011806958391 0.28153088261039994 0.20619100024019058 7.362271119937642e-08 7.132988193446701 -1.829977334633414 GEGPGEAGGPLT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 GEGPGEAGGPLTPR 14 0 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 GEGPGEAGGPLT(1)PR;GEGPGEAGGPLT(1)PR;GEGPGEAGGPLT(1)PR 129.77 0.0023985 73774600.0 44197.0 41405.0 51327.0 54388.0 53794.0 52167.0 66565.0 83455.0 104453.0 145588.0 True False 41740.70767460915 44580.63036194117 48024.67670061218 46980.26057546681 47035.91679553825 59352.53072512353 69660.40439604521 83697.84023328102 125346.51866066857 141384.49615694818 0.2952283228302034 0.3153148440862503 0.33967427834025676 0.33228721573060555 0.33268086723826207 0.41979518503384866 0.4927018611624612 0.5919873996677095 0.8865648077956428 1.0 17.10926440120498 -8.060352520627864 0.9456119791202923 1.01586410601273 0.3230692702953148 0.9845702907296002 0.02971456967544926 0.05697913946148071 0.09814445623361161 0.027382216796664794 0.010189012532757707 8.702569080442898e-09 8.060352520627864 -0.6927948357174152 down GEHGFIGCR ddPTM_A459_Selumetinib_30min_R1 3 GEHGFIGCR 9 0 Q16658;C9JPH9;C9JFC0;A0A0A0MSB2 Q16658;C9JPH9 FSCN1 Fascin 0 ;; 126.24 0.0068158 21409200.0 4179.6 3977.1 5031.900000000001 4744.7 4776.0 3833.5 4078.3999999999996 4156.8 2531.6499999999996 4132.4 False True 4276.976547914124 3511.45928309637 4348.595618248203 3916.1272140497163 4344.0116432712875 3794.938470539511 3770.7630044613225 4046.5481608106725 4296.025145599807 4662.833792984676 0.9172483381991695 0.7530740830564085 0.9326078971098541 0.8398599195068042 0.9316248093180884 0.8138695563734375 0.8086848409940128 0.8678302381051589 0.921333535856084 1.0 12.186991290297366 -8.526699025582953 2.300310852432255 0.9991434131066691 0.8554525738773912 0.39630029592278115 0.055071461220671816 0.2935357196413056 3.6286975393795937 0.05035962166214924 0.013817641828833025 2.973726167146279e-09 8.526699025582953 -0.14369083922927794 GEHGFIGCR ddPTM_A459_Selumetinib_30min_R2 2 GEHGFIGCR 9 0 Q16658;C9JPH9;C9JFC0;A0A0A0MSB2 Q16658;C9JPH9 FSCN1 Fascin 0 ; 126.24 0.0068158 16824000.0 12624.7 10272.4 12986.9 15407.0 14234.4 11381.9 10473.2 12371.4 10138.8 9396.099999999999 False True 11923.069714678326 11060.260049028007 12151.336993067596 13308.540021442555 12446.147414849424 12949.653410398972 10960.2245522521 12407.398725804478 12166.84330174133 9124.810179000333 1.3066649585892598 1.2121085076905909 1.33168107113422 1.45850047950264 1.3639897346569196 1.4191696217638654 1.2011454854672765 1.3597432146433723 1.3333804279832444 1.0 13.155578831852974 -10.838241538158456 2.7914102705458985 0.9959240867083894 1.3325143791928948 0.6326424435181779 0.07585429027340775 4625152.314421706 5501545.055368708 156682.70321995273 0.020337128602018587 1.4513042325888181e-11 10.838241538158456 0.33659029248450545 GEIDAHEDSFK ddPTM_A459_Selumetinib_30min_R2 1 GEIDAHEDSFK 11 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 110.08 0.012686 6457800.0 46892.0 35752.0 49118.0 44830.0 43717.0 39037.0 43095.0 54490.0 42678.0 42934.0 False True 44285.93036354889 38494.063439201105 45957.801355634845 38724.0766639365 38224.879625061265 44413.992407396385 45099.00289112248 54648.55687869489 51214.79252295312 41694.38386407132 1.062155769178082 0.9232433692915659 1.1022539991348181 0.9287600169409296 0.9167872524433733 1.0652272150654944 1.0816565376802454 1.3106934750938093 1.2283379145239193 1.0 15.3475654486603 -7.3692131555809635 2.443258613416478 1.199292997066786 0.9901213472408243 0.40210448989879977 0.09579121428789639 0.2535285887601721 2.951552598550365 0.046246025086560234 0.028183745223713405 4.2735308598758284e-08 7.3692131555809635 -0.2091716498259617 GEIPS(ph)PQLTRPK ddPTM_A459_Selumetinib_30min_R2 1 GEIPSPQLTRPK 12 1 Q8IWZ3-6;H7C0V5 Q8IWZ3-6 ANKHD1;ANKHD1-EIF4EBP3 Ankyrin repeat and KH domain-containing protein 1 1 GEIPS(0.952)PQLT(0.048)RPK 127.71 0.012122 7731900.0 21647.0 15379.0 16970.0 17934.0 16257.0 12560.0 19069.0 18730.0 15286.0 16063.0 True False 20443.946399806868 16558.519848721 15878.16867553898 15491.3582621244 14214.65032057601 14290.025991671962 19955.746284506666 18784.501199081584 18343.62712652564 15599.219453313866 1.3105749592787348 1.0614966920798938 1.017882255138468 0.9930854751090413 0.9112411273601435 0.9160731429184567 1.279278514173817 1.2041949441958164 1.1759323715795764 1.0 13.92918622152119 -7.264720062111314 24.945182962295124 1.1818676981857665 1.0279439330964255 0.20453393495515748 0.12310789285003164 414.2409191448001 3149723.2196308337 0.05189376968083069 0.036603368018672304 5.436006131111187e-08 7.264720062111314 -0.15392376508934102 GEIQGLVS(ph)ALQEVR ddPTM_A459_Selumetinib_30min_R1 1 GEIQGLVSALQEVR 14 0 A0A590UK13 A0A590UK13 1 GEIQGLVS(1)ALQEVR 71.241 0.036585 28964000.0 1237.2 1564.4 2480.5 3466.5 2080.3 1950.3 1709.5 1220.6 761.06 820.71 True False 1266.024352827867 1381.2393207301704 2143.6617244111912 2861.140849264094 1892.1372323067962 1930.681752730718 1580.5510386736541 1188.2257229324257 1291.4632343768649 926.0561228923757 1.3671140674213778 1.4915287384700928 2.3148291679297315 3.089597680460032 2.0432209080342063 2.0848431374769905 1.7067551302798767 1.2831033601086819 1.3945841968445751 1.0 9.854955819291504 -7.583550389228958 1.9058639318564994 1.2085856763689986 2.10213635613247 0.4117688230677391 0.44892853890623713 0.39749890036834473 2.846752594811987 0.3220998490177561 0.15401318351233037 2.608853012010984e-08 7.583550389228958 0.8935506797634714 GELS(ph)PSFLNPPLPPSIDDR ddPTM_A459_Selumetinib_30min_R1 3 GELSPSFLNPPLPPSIDDR 19 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GELS(0.983)PS(0.017)FLNPPLPPSIDDR;GELS(0.854)PS(0.146)FLNPPLPPSIDDR;GELS(0.946)PS(0.054)FLNPPLPPSIDDR 181.94 3.4198e-13 17256800.0 5843.15 6676.25 5558.12 5795.85 5954.4 5623.69 6143.950000000001 5153.65 2719.95 5647.1 True False 5979.284026209307 5894.591546295576 4803.357832567762 4783.713599078982 5415.825571334702 5567.120784501979 5680.506904977478 5016.958460585529 4615.556492711948 6371.9602924121 0.9383743387932906 0.9250829063255483 0.7538273328990653 0.7507444145211569 0.8499465349437301 0.8736904388954612 0.8914849817476072 0.7873492976031029 0.7243542459309226 1.0 12.63752156123676 -5.150595846851947 7.517469612250332 0.8232324416374894 0.9344064428518081 0.21671676048012112 0.07768143150247778 0.37761039623856263 22.778185515875965 0.019692331151712785 0.05290078539556981 7.069751572040996e-06 5.150595846851947 0.11117400121431864 GELS(ph)PSFLNPPLPPSIDDR ddPTM_A459_Selumetinib_30min_R2 5 GELSPSFLNPPLPPSIDDR 19 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GELS(0.975)PS(0.025)FLNPPLPPSIDDR;GELS(0.768)PS(0.232)FLNPPLPPSIDDR;GELS(0.95)PS(0.05)FLNPPLPPSIDDR;GELS(0.888)PS(0.112)FLNPPLPPSIDDR;GELS(0.912)PS(0.088)FLNPPLPPSIDDR 191.97 3.015e-15 10497200.0 45707.1 35333.5 46253.0 45250.7 52060.7 32098.8 41140.4 39587.0 40475.299999999996 42422.0 True False 43166.88236201838 38043.46583489067 43277.13233645868 39087.476598188536 45520.36943743688 36520.11833610508 43053.51011815606 39702.191616019336 48571.49097437281 41197.16663440705 1.047811922239484 0.9234485995723193 1.0504880765347218 0.948790409424503 1.104939323652884 0.8864716027729006 1.0450599794937994 0.9637117030000034 1.1790007649168495 1.0 15.330257497951791 -8.236562690346396 24.92393070751026 1.0895004537091162 0.9957120930062046 0.1972980115286429 0.07515478341827654 931.5280112546271 933300.0751117663 0.04580083273281535 0.01729259105745415 5.800124417665106e-09 8.236562690346396 -0.09378836070291163 GELS(ph)PSFLNPPLPPSIDDRDLSTEEVR ddPTM_A459_Selumetinib_30min_R1 1 GELSPSFLNPPLPPSIDDRDLSTEEVR 27 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GELS(0.691)PS(0.163)FLNPPLPPS(0.143)IDDRDLS(0.001)T(0.001)EEVR 116.52 4.6117e-12 12152000.0 1009.5 1001.5 1427.8 1343.1 1241.7 1012.2 1173.0 1092.6 744.74 892.94 True False 1033.0193858549399 884.2439144152812 1233.9126023440028 1108.5527981095063 1129.3884542399412 1002.0181870040667 1084.5196656122826 1063.6206987350222 1263.769386342504 1007.5575469721555 1.0252708532225288 0.8776113255987729 1.2246571980449894 1.1002377000111359 1.1209170708252882 0.994502189989311 1.0763848366491904 1.05564262997319 1.2542900305201417 1.0 9.976646525758126 -5.249399339191519 24.99930727975115 1.100984980947861 0.9514410935330809 0.33165824023609647 0.08619421991935028 861.4831895242603 1788730.8776002692 0.021311468018232988 0.055448912803465554 5.631196221788758e-06 5.249399339191519 -0.14954388741477997 GELSPSFLNPPLPPS(ph)IDDRDLSTEEVR ddPTM_A459_Selumetinib_30min_R1 1 GELSPSFLNPPLPPSIDDRDLSTEEVR 27 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GELS(0.025)PS(0.162)FLNPPLPPS(0.797)IDDRDLS(0.006)T(0.009)EEVR 111.88 3.9274e-10 10871000.0 674.38 600.43 906.03 850.57 721.35 684.42 586.13 597.41 429.65 626.03 True False 690.091741884948 530.1313764676657 782.996102466548 702.0339166763476 656.1040198646862 677.5353562036394 541.91774220403 581.5647461388332 729.0846696055766 706.3870485485907 0.9769314758854589 0.7504828656710562 1.108451951483773 0.9938374693007362 0.9288166044561253 0.959155972063428 0.7671682872973183 0.8232947466035383 1.0321319892594614 1.0 9.46431508150684 GEMMDLQHGS(ph)LFLR ddPTM_A459_Selumetinib_30min_R1 1 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-4;P00338-2;F5GYU2;F5GXY2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 GEMMDLQHGS(1)LFLR 89.46799999999998 0.018942 0.0 1433.5 2035.1 1552.5 1550.1 1318.1 1511.8 2050.3 1918.8 879.68 1548.4 True False 1466.897760894559 1796.8295459076783 1341.6790272720718 1279.4041339807497 1198.878087729455 1496.5926646045723 1895.6442202939998 1867.907190859198 1492.7527107148462 1747.1522226932234 0.839593563652597 1.0284333114019553 0.7679233725862092 0.7322797163080369 0.6861898306041088 0.856589737955165 1.0849908758218427 1.0691153103876843 0.8543919020483389 1.0 10.770789594895819 -7.113921407734372 5.710737948247471 1.0065211812835528 0.8122063509164843 0.43895712241197893 0.1025844115176771 0.23890935487607634 10.418704348490426 0.04292522394504747 0.03319586538395229 7.692696388631179e-08 7.113921407734372 -0.19431483036706854 GEMMDLQHGS(ph)LFLR ddPTM_A459_Selumetinib_30min_R2 1 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-4;P00338-2;F5GYU2;F5GXY2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 GEMMDLQHGS(1)LFLR 112.82 0.0027995 0.0 12738.0 7983.4 9943.2 9883.8 10335.0 10065.0 10109.0 7740.2 9902.6 9317.9 True False 12030.07295425416 8595.701109323061 9303.4653373376 8537.609389493986 9036.624903927719 11451.362389026937 10579.088530603483 7762.722700540907 11883.396701761923 9048.868016188337 1.329456119012066 0.9499200445785524 1.0281358199383384 0.9435002670190664 0.9986470006813322 1.265502200776999 1.1691062917126869 0.8578667173234786 1.3132467708118454 1.0 13.143521611711478 GEMMDLQHGSLFLR ddPTM_A459_Selumetinib_30min_R1 1 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-4;P00338-2;F5GYU2;F5GXY2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 103.3 0.0098159 5933400.0 2176.4 2631.3 1621.3 1880.2 3752.8 1973.6 3120.9 2387.8 1052.6 1640.3 False True 2227.1058854627945 2323.2261727418168 1401.1363651634194 1551.8583657251822 3413.359902610655 1953.7473758854248 2885.4880003489943 2324.4677873324963 1786.1853211377384 1850.848482875027 1.2032891433680761 1.2552222368483772 0.7570238072578235 0.8384578100712995 1.844213577822692 1.0555955249511073 1.559008220849501 1.2558930721988488 0.9650629631028231 1.0 10.853971080490796 GEPAAAAAPEAGAS(ph)PVEK ddPTM_A459_Selumetinib_30min_R1 2 GEPAAAAAPEAGASPVEK 18 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEPAAAAAPEAGAS(1)PVEK;GEPAAAAAPEAGAS(1)PVEK 207.76 1.7058e-11 146906000.0 19697.2 22106.8 10725.2 9728.6 14650.0 13334.1 20640.2 19151.9 9992.4 17498.7 True False 20156.106435920683 19518.525578827495 9268.77674930655 8029.6826384395345 13324.910086667569 13199.971060394117 19083.293096479647 18643.929397861317 16956.372983979436 19744.82859677209 1.020829648489115 0.9885386182596899 0.4694280684118889 0.40667269402137207 0.6748556981064876 0.6685280145988233 0.9664957587729786 0.9442436689933712 0.8587753953332107 1.0 14.269187223485456 -7.26070404203288 24.999999993116568 0.9377323533091277 0.6920933265149131 0.2840055478118313 0.18407221245536626 100.15106372857123 3405011.031298227 0.082630984377531 0.06014230910152922 5.4865072568728545e-08 7.26070404203288 -0.24563902679421468 GEPAAAAAPEAGAS(ph)PVEK ddPTM_A459_Selumetinib_30min_R2 4 GEPAAAAAPEAGASPVEK 18 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 GEPAAAAAPEAGAS(1)PVEK;GEPAAAAAPEAGAS(1)PVEK;GEPAAAAAPEAGAS(1)PVEK;GEPAAAAAPEAGAS(1)PVEK 248.65 7.481999999999999e-33 217400000.0 745828.0 505683.0 641265.0 648368.0 620116.0 510226.0 716057.0 688140.0 616427.0 593578.0 True False 704377.8655460419 544467.2600728776 600006.70805654 560059.1599028154 542211.4841726221 580505.0001295236 749355.0693400274 690142.373472291 739729.6244094492 576439.8608391405 1.2219451037280078 0.9445343687375828 1.040883444776169 0.9715829836741698 0.9406210795056901 1.007052148136434 1.2999709427609139 1.197249566446759 1.2832728523190657 1.0 19.136810575817968 -7.2456288483753735 24.357620061063095 1.2115608004337153 1.012612675723669 0.3841848013365974 0.10680489996429988 513.1677594593842 790584.4197978881 0.038891886308904555 0.030010585131285843 5.68029840994742e-08 7.2456288483753735 -0.1989481247100462 GEPGLPGPPGPMDPNLLGS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GEPGLPGPPGPMDPNLLGSK 20 0 H0Y9H0;Q49AM6;P29400;P29400-2 H0Y9H0 COL4A5 Collagen alpha-5(IV) chain 1 GEPGLPGPPGPMDPNLLGS(1)K 69.331 0.012261 45653000.0 4667.3 4087.0 3847.8 3073.3 2089.3 4779.4 4041.6 3134.1 2657.3 2371.9 True False 4776.039009015122 3608.4921400052476 3325.2898944524823 2536.605847985962 1900.3231838958752 4731.323575347992 3736.7388580891716 3050.9734870084517 4509.244018486904 2676.3564692624977 1.7845302237826404 1.34828532052743 1.2424689807366378 0.9477832557502904 0.7100411345501865 1.7678226460811348 1.3962037198725157 1.1399727659780627 1.6848443285768582 1.0 11.386054568872762 GEPNVS(ph)YICSR ddPTM_A459_Selumetinib_30min_R1 1 GEPNVSYICSR 11 0 P49841;P49841-2;A0A3B3ITW1;A8MT37;P49840 P49841;P49840 GSK3B;GSK3A Glycogen synthase kinase-3 beta;Glycogen synthase kinase-3 alpha 1 GEPNVS(0.63)Y(0.37)ICSR 155.0 0.000533 22507000.0 1332.0 1977.5 1780.9 1984.6 1880.2 1322.5 1355.8 1611.0 818.05 1446.8 True False 1363.0330083791775 1745.9733806851903 1539.0635617834678 1638.0268655558975 1710.1362419762702 1309.1968507339245 1253.5309144391576 1568.2710467345055 1388.1711019919508 1632.5108730254167 0.8349304319506093 1.0695018388756588 0.9427585366897008 1.003378839688987 1.0475496795969241 0.8019529133718312 0.7678545577562235 0.9606496793666923 0.8503288553413134 1.0 10.672876885259281 -6.761048723023671 24.999997288469476 0.8669288924378201 0.9838887316632665 0.25558119675257673 0.08743406307737883 13.370327642734175 855652.9003772766 0.028964413722907152 0.02728593385662207 1.7336094950876858e-07 6.761048723023671 0.1169598392254464 GEPNVS(ph)YICSR ddPTM_A459_Selumetinib_30min_R2 3 GEPNVSYICSR 11 0 P49841;P49841-2;A0A3B3ITW1;A8MT37;P49840 P49841;P49840 GSK3B;GSK3A Glycogen synthase kinase-3 beta;Glycogen synthase kinase-3 alpha 1 GEPNVS(0.846)Y(0.154)ICSR;GEPNVS(0.832)Y(0.168)ICSR;GEPNVS(0.87)Y(0.13)ICSR 159.58 0.00053549 237637000.0 140800.0 117891.0 146511.0 164280.0 167731.0 122885.0 128582.0 133819.0 121937.0 149137.0 True False 132974.8996670582 126932.86062068824 137084.64176911538 141904.78060119328 146659.13224583454 139811.2933110358 134561.31778039923 134208.39113507202 146327.80720444533 144831.02730553868 0.9181382065773204 0.8764203567575884 0.9465143230664148 0.9797954432914977 1.0126223294435333 0.9653407554452188 0.9290917856746659 0.9266549691175157 1.0103346632745276 1.0 17.144011180067075 -5.451509109897064 4.297149569786052 0.9707378606924836 0.898080542181428 0.5116852415428714 0.029800973082928145 0.19039785898854075 6.6515674432042955 0.008448218156721227 0.018099690405112456 3.5358260416315812e-06 5.451509109897064 -0.07265731851105561 GEPNVSY(ph)ICSR ddPTM_A459_Selumetinib_30min_R1 5 GEPNVSYICSR 11 0 P49841;P49841-2;A0A3B3ITW1;A8MT37;P49840 P49841;P49840 GSK3B;GSK3A Glycogen synthase kinase-3 beta;Glycogen synthase kinase-3 alpha 1 GEPNVS(0.042)Y(0.958)ICSR;GEPNVS(0.303)Y(0.697)ICSR;GEPNVS(0.006)Y(0.994)ICSR;GEPNVS(0.363)Y(0.637)ICSR;GEPNVS(0.125)Y(0.875)ICSR 222.18 0.00011555 1312689000.0 11645.8 13941.1 14625.7 14419.699999999999 14284.2 12690.8 13191.4 12161.5 6577.32 10656.71 True False 11917.124481217892 12308.86953095844 12639.61027321942 11901.57008629264 12992.196632080337 12563.142074324447 12196.362077542934 11838.93751388063 11161.231651553933 12024.602533645748 0.9910618207855832 1.0236404485318573 1.0511457853058206 0.9897682732540345 1.0804678654223445 1.0447864733301433 1.0142840100881996 0.9845595711587461 0.9281996324056419 1.0 13.553701586874066 -7.786583561829735 2.853609366662351 0.9625793367725036 1.0309413532853797 0.43856816946681254 0.03022652248134836 0.2314115508446731 3.7917139897213903 0.018673106200117105 0.008314825108368673 1.6346186068081206e-08 7.786583561829735 0.0683620165128761 GEPNVSY(ph)ICSR ddPTM_A459_Selumetinib_30min_R2 3 GEPNVSYICSR 11 0 P49841;P49841-2;A0A3B3ITW1;A8MT37;P49840 P49841;P49840 GSK3B;GSK3A Glycogen synthase kinase-3 beta;Glycogen synthase kinase-3 alpha 1 GEPNVS(0.091)Y(0.909)ICSR;GEPNVS(0.392)Y(0.608)ICSR;GEPNVS(0.015)Y(0.985)ICSR 197.73 0.00027934 1128915900.0 1014153.0 940017.0 1151950.0 1144975.0 1307673.0 880357.0 940510.0 973875.0 790074.0 1037734.0 True False 957790.4362361227 1012113.2812689487 1077834.7911483282 989027.4298079582 1143391.426995055 1001618.1856648372 984245.5785852086 976708.815016315 948110.8765120119 1007771.923063263 0.9504039697045592 1.0043078777115457 1.0695225442202234 0.9814000640161434 1.1345736082024966 0.9938937201388578 0.9766550903635589 0.9691764502105522 0.9407990586105008 1.0 19.94273773723222 -6.9916742093371855 24.99785930996893 0.9714012014538279 1.030216094382874 0.23129991828491958 0.04862780967586121 279.06975063173314 837891.6536781297 0.017189693414698646 0.015136126538209524 1.0193557819801702e-07 6.9916742093371855 0.05881489292904607 GEPPAAS(ph)PEASTCQSK ddPTM_A459_Selumetinib_30min_R1 2 GEPPAASPEASTCQSK 16 0 Q7Z333-3;Q7Z333;Q7Z333-4;X6RI79 Q7Z333-3 SETX Probable helicase senataxin 1 GEPPAAS(0.998)PEAS(0.001)TCQSK;GEPPAAS(0.926)PEAS(0.028)T(0.046)CQSK 174.59 2.6328e-06 6756200.0 1346.17 2101.8999999999996 1747.63 1957.1799999999998 2298.8999999999996 1742.9 1957.3200000000002 1638.1 662.37 1320.09 True False 1377.5331418091575 1855.8085708531996 1510.311445044439 1615.3952538187502 2090.964900903759 1725.3680084265843 1809.6777765526285 1594.6522667013003 1123.9935124092774 1489.5364102654974 0.9248066259512406 1.2458967488565234 1.013947315846572 1.0844953118875553 1.4037689085633442 1.1583255008308604 1.214926848434721 1.0705695112327378 0.7545928415465419 1.0 10.540647673954435 -8.064824073360274 5.545673793276302 0.8816526128633175 1.1550444796187083 0.3872783051995533 0.13490531833483857 0.21844084322835386 13.066615295818389 0.09181988733131613 0.03422474791355772 8.613425994015179e-09 8.064824073360274 0.27339186675539073 GEPPAAS(ph)PEASTCQSK ddPTM_A459_Selumetinib_30min_R2 3 GEPPAASPEASTCQSK 16 0 Q7Z333-3;Q7Z333;Q7Z333-4;X6RI79 Q7Z333-3 SETX Probable helicase senataxin 1 GEPPAAS(0.994)PEAS(0.005)TCQSK;GEPPAAS(0.99)PEAS(0.008)T(0.002)CQSK;GEPPAAS(0.974)PEAS(0.009)T(0.017)CQSK 205.98 5.1659e-09 7563600.0 47783.0 51454.0 56903.0 57523.0 58549.0 38406.9 41896.5 50417.0 39620.4 52123.0 True False 45127.41215050453 55400.3563493134 53241.922931301975 49688.26816729018 51193.55118529893 43697.101851874664 43844.77026633981 50563.70512301634 47545.58708647105 50618.07355818205 0.8915276496770196 1.0944777715737135 1.0518362155782952 0.9816309605338276 1.011369014793805 0.8632707406702826 0.8661880467644272 0.9989259086459856 0.9393006043942115 1.0 15.62736498140848 -6.699478987807642 15.662236297438449 0.9292642056843012 1.0122643385634804 0.23456328098555934 0.06490939110293181 3.2970840613960353 831.7202185420797 0.021598924137270308 0.021597922985615525 1.9976574174867514e-07 6.699478987807642 0.08300013287917918 GEPPAPKS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 1 GEPPAPKSPPK 11 1 O95466;O95466-2;O95466-3;K7EK60;K7ERL1;K7EJE6 O95466 FMNL1 Formin-like protein 1 1 GEPPAPKS(1)PPK 76.357 0.028339 12695000.0 4101.7 5607.4 4323.8 4919.8 3812.1 4915.1 4202.4 4245.0 2616.1 4253.7 True False 4197.261629481139 4950.883001190466 3736.651708933325 4060.6492860837993 3467.296228080918 4865.658556553734 3885.4095846283503 4132.408810296693 4439.330627615849 4799.703829546733 0.8744834636760314 1.0314976042298862 0.7785171422308783 0.8460208025934118 0.7223979543771886 1.0137414160017515 0.809510278678023 0.8609716259694598 0.9249176168511806 1.0 12.228729670323611 -8.550165535670493 2.958337894589345 0.9996338854052923 0.8673365397711555 0.17546537479555624 0.09013119070249913 0.46449950198708834 10.389301578860392 0.08578899492483501 0.02290198179277646 2.8173088812241595e-09 8.550165535670493 -0.13229734563413675 GEQVSQNGLPAEQGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 GEQVSQNGLPAEQGSPR 17 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR 234.51 6.0022e-17 270591300.0 11086.5 12530.099999999999 8359.0 8740.3 9464.2 8542.300000000001 10544.3 9679.0 5947.8 11277.6 True False 11344.793879426248 11063.070066914543 7223.893712700323 7213.970680750887 8608.164781040221 8456.37221778783 9748.93496173537 9422.28147817708 10092.982189875594 12725.189813126502 0.891522566345036 0.8693835007083807 0.56768455471278 0.5669047602975171 0.6764665130700511 0.6645380023380689 0.7661131271832962 0.7404432952707432 0.7931498341552683 1.0 13.635399555725778 -8.8404566707462 0.9745637198786414 0.9999782894038225 0.7042976597175029 0.4103421482667732 0.10254635538203376 1.1947920807413253 2.048485748450108 0.10989078507349455 0.03576663081537274 1.4439206560489347e-09 8.8404566707462 -0.2956806296863196 GEQVSQNGLPAEQGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 GEQVSQNGLPAEQGSPR 17 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR;GEQVSQNGLPAEQGS(1)PR 244.01 1.5025999999999995e-78 560733000.0 99829.0 73591.0 99029.0 103961.0 110437.0 83513.0 102593.0 91309.0 93038.0 87502.0 True False 94280.90382715022 79235.19306763969 92657.58195462289 89801.33245727204 96562.91674069343 95016.15769446666 107363.7777841728 91574.69407298122 111648.19969892026 84975.58990250068 1.1095057290608548 0.932446519742347 1.0904023386120223 1.0567897505661135 1.1363606519411966 1.1181582593717363 1.2634661072357354 1.0776588215280674 1.313885550274181 1.0 16.374760851573335 -6.252175179227256 1.3096961299991206 1.1686184802071107 1.0280624316162346 0.2296455612515329 0.09361765659516914 0.5575835421076502 1.9411657848009964 0.03428675488770844 0.049195846162795674 5.595318603580298e-07 6.252175179227256 -0.14055604859087611 GES(ph)AAATASLFQR ddPTM_A459_Selumetinib_30min_R1 2 GESAAATASLFQR 13 0 H3BV60 H3BV60 TGFBR3L Transforming growth factor-beta receptor type 3-like protein 1 GES(0.668)AAAT(0.332)ASLFQR;GES(0.966)AAAT(0.034)ASLFQR 84.352 0.029256 64762000.0 4876.8 7094.5 5400.0 5974.1 5310.5 6307.8 6964.5 6752.6 3871.9 5129.9 True False 4990.419951399082 6263.872641856432 4666.709660076772 4930.835582745887 4830.1662126449255 6244.349259024163 6439.162157848879 6573.499112463951 6570.331507612783 5788.37263445748 0.8621455919564883 1.082147442368924 0.8062213604384099 0.8518517887727582 0.8344601354604457 1.078774580242521 1.112430481672401 1.135638551210872 1.1350913153898208 1.0 12.498942085000833 -6.828957637442674 6.33897634556085 1.104426805263917 0.8919842578739978 0.6255187963980628 0.07911011312440278 0.14055435634128094 10.095816407501086 0.028665668869698565 0.02540811431289228 1.4826627020432604e-07 6.828957637442674 -0.2124425473899192 GES(ph)ENAGTNQETR ddPTM_A459_Selumetinib_30min_R1 2 GESENAGTNQETR 13 0 Q08170 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 1 GES(0.991)ENAGT(0.009)NQETR;GES(1)ENAGTNQETR 127.57 0.0019137 1557650.0 259.65999999999997 295.94 342.67 194.98 308.949 225.562 0.0 295.11 0.0 255.91 True False 265.7095727895927 261.2912072212267 296.1372961515756 160.9304032278992 281.0046174993762 223.29305107390974 0.0 287.28272414762256 0.0 288.7585412744914 0.9201790936359228 0.9048778473113478 1.0255533735712774 0.5573182442244025 0.9731473786337479 0.7732863938443617 0.0 0.9948890961965834 0.0 1.0 8.173719810838849 -5.764274857765658 24.97244030605693 0.6098852349676283 0.9456709059642845 0.16331545542985826 0.3484903622543065 129.19181464020755 1137826.4228636678 0.09357052137999193 0.14604930955523185 1.7207791777255043e-06 5.764274857765658 0.33578567099665624 GES(ph)ENAGTNQETR ddPTM_A459_Selumetinib_30min_R2 1 GESENAGTNQETR 13 0 Q08170 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 1 GES(0.993)ENAGTNQET(0.006)R 76.85 0.044297 5363100.0 0.0 964.99 516.13 2092.0 905.95 2347.9 1034.8 1216.3 2080.5 945.59 True False 0.0 1039.0016300680982 482.9227577198544 1807.0659910987104 792.1364617042399 2671.301912885875 1082.9202504173002 1219.8392316306958 2496.658134026991 918.2883597621272 0.0 1.1314546449627658 0.5258944563393468 1.967863331695516 0.8626227843173732 2.9090011699351686 1.179281256159905 1.3283836375173939 2.718817142225045 1.0 9.842803447851377 -5.28683375778153 0.8779282565019725 1.7657810712684472 1.9897278936858273e-14 0.3462553639146806 0.705959139854641 1.3891991314184258 1.3770616013086785 0.2610615421701375 2.0413504643396467 5.166140845084405e-06 5.28683375778153 -1.7657810712684272 GESAADS(ph)DGWDSAPSDLR ddPTM_A459_Selumetinib_30min_R2 4 GESAADSDGWDSAPSDLR 18 0 I3L0Y2;I3L4Q4;Q9BUL5-4;Q9BUL5;A0A087WVQ2;Q9BUL5-2 I3L0Y2 PHF23 PHD finger protein 23 1 GES(0.001)AADS(0.999)DGWDSAPSDLR;GESAADS(1)DGWDSAPSDLR;GESAADS(0.999)DGWDS(0.001)APSDLR;GES(0.007)AADS(0.825)DGWDS(0.167)APS(0.001)DLR 164.8 1.404e-06 21465700.0 36309.9 29726.2 39317.9 40707.2 44586.6 34257.100000000006 38406.6 41463.100000000006 41299.6 37234.200000000004 True False 34291.94111804627 32006.10395520193 36788.22912009276 35162.80913616317 38985.232698738626 38975.70457000842 40192.58300123414 41583.7507564143 49560.67400723918 36159.151899930206 0.9483613225483991 0.8851453165654504 1.0173974550593308 0.9724456268630304 1.0781567224427593 1.0778932171272426 1.111546617920309 1.1500200798817564 1.3706260076120547 1.0 15.142073219799405 -6.532465125682511 0.769214001120527 1.1826977055202241 0.9233923847673818 0.5046090101851215 0.09013653283912716 0.5261747251648357 0.6924849901832523 0.055573845686083964 0.06977685736305715 2.9345051384373744e-07 6.532465125682511 -0.2593053207528423 GESAEDKEHEEGRDS(ph)EEGPR ddPTM_A459_Selumetinib_30min_R1 1 GESAEDKEHEEGRDSEEGPR 20 2 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;A0A087WX58;K7EPS6 Q7Z4V5-2 HDGFRP2 Hepatoma-derived growth factor-related protein 2 1 GESAEDKEHEEGRDS(1)EEGPR 106.02 0.00054517 7200700.0 1192.1 1581.6 1085.7 977.47 831.32 1101.8 1163.9 1308.0 797.78 1520.8 True False 1219.8736105771914 1396.4255367341082 938.2679033232127 806.7732138843714 756.1272527814666 1090.7168923543584 1076.1060859387349 1273.3075910172154 1353.7743924541762 1716.0094938464567 0.7108781244810187 0.8137632931179203 0.5467731423909978 0.47014495944074247 0.44063115938047515 0.6356123880815501 0.6270979792347359 0.7420166354459267 0.7889084514443298 1.0 10.74484181925206 -8.407258872464638 1.0742893232005768 0.9930693546821683 0.5976574255100394 0.5858883146802871 0.10391316642118416 0.39779568027979223 0.9942438186318255 0.11212817368698422 0.036889749920070734 3.915084388047949e-09 8.407258872464638 -0.39541192917212886 GESEDDFWWCIDR ddPTM_A459_Selumetinib_30min_R1 1 GESEDDFWWCIDR 13 0 H0Y8B3;O43865-2;Q96HN2-4;Q96HN2-3;O43865;Q96HN2-2;Q96HN2 H0Y8B3 AHCYL2;AHCYL1 Adenosylhomocysteinase;Putative adenosylhomocysteinase 2;Putative adenosylhomocysteinase 3 0 143.0 0.010331 1815900.0 1144.5 1236.3 1474.4 1467.6 1041.5 1076.1 1079.9 1021.4 638.48 876.02 False True 1171.1646231906677 1091.5534212597224 1274.1845782994797 1211.3112102639493 947.2965088917595 1065.2754110206254 998.4422735675221 994.3091540252168 1083.4539272658408 988.4657001573988 1.1848308170978281 1.1042906406220352 1.2890529009722687 1.2254458703737172 0.9583504098735204 1.0777059951103976 1.0100929889712253 1.0059116405019288 1.0960966345046839 1.0 9.949047094958983 -6.252547783145428 24.989708272572177 1.0269091808995696 1.2003003104939538 0.7029249666404791 0.05610864644003205 376.02901763689925 1056824.4448700002 0.016836054377869503 0.02139918481016631 5.590520146238291e-07 6.252547783145428 0.17339112959438419 GESENAGTNQETR ddPTM_A459_Selumetinib_30min_R2 1 GESENAGTNQETR 13 0 Q08170 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 0 117.86 0.038991000000000005 0.0 3976.4 3462.4 4940.5 4721.9 3993.1 3983.5 3687.1 5142.1 4182.1 6135.4 False True 3755.407606790408 3727.9549466292738 4622.6336088096805 4078.769074268164 3491.4510792330716 4532.190966387362 3858.5574558500434 5157.062659679516 5018.63685763724 5958.255060316368 0.6302864796444289 0.6256789796493419 0.7758368116191774 0.6845576486703124 0.5859855014410351 0.7606574274694972 0.6475985698479252 0.8655323760855732 0.8422997684444148 1.0 12.540674168299436 -8.19447297828968 0.9575434424281375 0.9921268971974865 0.667472733327865 0.7350546401744099 0.06427706075022505 0.2610053232152232 0.48466287119019547 0.05918985503095664 0.021181988974730285 6.3903849695074905e-09 8.19447297828968 -0.3246541638696214 GESPVDYDGGR ddPTM_A459_Selumetinib_30min_R2 2 GESPVDYDGGR 11 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 ; 139.38 0.016249 34518000.0 171733.0 175565.0 199180.0 219166.0 215296.0 150766.0 153875.0 178504.0 164325.0 169596.0 False True 162188.767361668 189030.27096954937 186364.97565078663 189315.21271756178 188248.5917093396 171532.64798251694 161030.49239752808 179023.41708707184 197194.5916241217 164699.32281667265 0.9847567348057699 1.147729497224221 1.1315467025825607 1.1494595695957364 1.1429833984131175 1.0414896980083548 0.9777240710137688 1.0869711789060807 1.197300561117787 1.0 17.329475097679364 -6.765812970858519 24.988251322092022 1.0609469840959809 1.1165646383026464 0.1100415446172911 0.07116024018710472 254.63807002750414 1454848.7054596555 0.025337102363096276 0.023143425794022173 1.7146955830603475e-07 6.765812970858519 0.055617654206665534 GESS(ph)SPSPSAEK ddPTM_A459_Selumetinib_30min_R1 1 GESSSPSPSAEK 12 0 E9PHV5;P28290-3;P28290;P28290-2 E9PHV5 SSFA2 Sperm-specific antigen 2 1 GES(0.039)S(0.777)S(0.081)PS(0.103)PSAEK 151.16 0.00052989 6356500.0 3848.0 3959.4 3250.2 3314.3 3419.7 3379.3 3800.8 3672.9 2136.6 3495.2 True False 3937.650913095403 3495.831607324878 2808.8406920706516 2735.519722116252 3110.38873879707 3345.3073101589052 3514.102595958363 3575.482760739397 3625.654148910216 3943.8429661310693 0.9984299443236351 0.8864023332942963 0.712209060095042 0.6936178102445624 0.7886695199348613 0.8482354238968772 0.8910351213617707 0.9065986631427579 0.9193201098640603 1.0 11.945386393047723 -7.830205674875958 1.0039645138410291 0.9758722065778832 0.8106205742131072 0.3216716167328495 0.08263485850448418 0.7083864161760104 1.2964169735291187 0.08247041315502679 0.03249446249120964 1.4784080720865108e-08 7.830205674875958 -0.16525163236477602 GESSS(ph)PSPSAEK ddPTM_A459_Selumetinib_30min_R1 1 GESSSPSPSAEK 12 0 E9PHV5;P28290-3;P28290;P28290-2 E9PHV5 SSFA2 Sperm-specific antigen 2 1 GESS(0.002)S(0.907)PS(0.084)PS(0.007)AEK 166.24 0.00047855 3291800.0 2594.6 2944.0 2820.7 2507.3 3235.9 2292.4 2777.0 2706.5 1908.0 2389.8 True False 2655.0491317872493 2599.31511137153 2437.6644329960263 2069.447122850097 2943.213416344545 2269.340537332666 2567.528654224474 2634.714828049 3237.736645193621 2696.5541086232643 0.9846081424054177 0.9639395341852124 0.9039924046770139 0.7674413490284684 1.091472040903052 0.8415705548335116 0.9521517280197783 0.9770672947460949 1.200694113587307 1.0 11.396901267688849 -8.062630754556938 5.500863979624822 1.1005645485250695 0.9284915648864218 0.34617183024882825 0.0926701885686345 0.23045982387648445 13.882360789730813 0.0614032238653272 0.02291474145645371 8.657036436996948e-09 8.062630754556938 -0.17207298363864765 GESSS(ph)PSPSAEK ddPTM_A459_Selumetinib_30min_R2 2 GESSSPSPSAEK 12 0 E9PHV5;P28290-3;P28290;P28290-2 E9PHV5 SSFA2 Sperm-specific antigen 2 1 GESS(0.167)S(0.706)PS(0.077)PS(0.049)AEK;GES(0.017)S(0.042)S(0.939)PS(0.002)PS(0.001)AEK 132.14 0.0019254 3732500.0 43075.0 34039.0 37317.0 44944.0 44070.0 38378.0 44333.0 44924.0 36591.0 43007.0 True False 40681.06394288727 36649.68184736425 34916.06484767753 38822.5496672755 38533.53260920123 43664.22113920276 46394.57234417297 45054.72140243142 43910.222437962824 41765.27616439455 0.9740403435322765 0.8775156113682923 0.8360070387238081 0.92954131356546 0.9226212813133887 1.0454670757433442 1.1108407894049785 1.0787602894109718 1.0513571672584048 1.0 15.350016357151336 -6.7544058146550325 3.2747615836850303 1.0687616684413417 0.9000261651847807 0.7574433721202739 0.042278580518789736 0.11276334626468733 2.519377135436987 0.015499356513525181 0.014498874625829996 1.7603303848560725e-07 6.7544058146550325 -0.16873550325656095 GEVISSGSKPLS(ph)PGPCLDIPSILSNK ddPTM_A459_Selumetinib_30min_R1 1 GEVISSGSKPLSPGPCLDIPSILSNK 26 1 Q8TEP8-1;H0Y966;A0A0A0MR42;K7ENP4;Q8TEP8;K7EPA2;Q8TEP8-2;C9JT09 Q8TEP8-1 CEP192 Centrosomal protein of 192 kDa 1 GEVISSGSKPLS(1)PGPCLDIPSILSNK 108.31 1.4769e-08 23680000.0 2239.4 2871.8 3192.4 3216.8 3012.3 2424.8 2468.0 2921.5 1666.9 2419.9 True False 2291.5736628861337 2535.568320936401 2758.889614597978 2655.0462668145788 2739.837996864759 2400.408713542246 2281.8367730018003 2844.0123296305756 2828.607554440907 2730.517736822091 0.83924511164435 0.9286034976968941 1.010390658662744 0.972360014736491 1.0034133673321293 0.8791038714643026 0.835679161585492 1.0415652281902315 1.035923523328941 1.0 11.414958812923508 -4.83557642786585 3.3688917672246315 0.966889177411511 0.8299281274935485 0.2885840412598105 0.06304663846730074 0.4037043366637366 7.5359778695043875 0.01734562824937333 0.1323932566804163 1.460237751758596e-05 4.83557642786585 -0.13696104991796254 GEVISSGSKPLS(ph)PGPCLDIPSILSNK ddPTM_A459_Selumetinib_30min_R2 1 GEVISSGSKPLSPGPCLDIPSILSNK 26 1 Q8TEP8-1;H0Y966;A0A0A0MR42;K7ENP4;Q8TEP8;K7EPA2;Q8TEP8-2;C9JT09 Q8TEP8-1 CEP192 Centrosomal protein of 192 kDa 1 GEVISS(0.001)GS(0.001)KPLS(0.997)PGPCLDIPSILSNK 100.14 1.1136e-06 4726300.0 37293.0 31604.0 35176.0 35838.0 37801.0 31271.0 32889.0 35140.0 28285.0 31647.0 True False 35220.404355707375 34027.92517712328 32912.81445673299 30956.802576001683 33052.10043477233 35578.2964001253 34418.40366831712 35242.25158225985 33942.7903489322 30733.26888121917 1.1460025450540425 1.1072016227313017 1.0709181175597535 1.0072733458860639 1.0754502087791311 1.157647646842633 1.1199070232763266 1.146713410749355 1.1044315032064271 1.0 14.907513603945716 -6.653860903814291 23.0483809886413 1.115892020094274 1.0781038144263988 0.03304400562873222 0.051773215918079575 12.86596488294261 2705.5927987538576 0.017183321622784728 0.017183318729666715 2.218906979315543e-07 6.653860903814291 -0.03778820566787511 GEVPGGSAHYGGPS(ph)PEKK ddPTM_A459_Selumetinib_30min_R1 4 GEVPGGSAHYGGPSPEKK 18 1 J3KS37;O94762-4;O94762 J3KS37 RECQL5 ATP-dependent DNA helicase Q5 1 GEVPGGSAHYGGPS(0.999)PEKK;GEVPGGS(0.093)AHY(0.021)GGPS(0.886)PEKK;GEVPGGSAHYGGPS(1)PEKK;GEVPGGS(0.032)AHYGGPS(0.968)PEKK 112.58 0.00062933 50200500.0 7742.6 8943.8 10465.9 10873.5 10127.9 8635.400000000001 10145.400000000001 8324.1 3522.91 6586.620000000001 True False 7922.987515522996 7896.655738140179 9044.688265073606 8974.64734587426 9211.833233225976 8548.53571631587 9380.124309891602 8103.317827512536 5978.120966833889 7432.076836111881 1.0660529607317593 1.062509970264428 1.2169799188735742 1.2075557806758872 1.2394695905815178 1.150221654703461 1.2621134733583903 1.0903167454000404 0.8043674868627119 1.0 12.859549701681974 -8.07270101432516 5.285365732005894 0.9080545508395397 1.1732106063010854 0.6570705102839639 0.07692717228282346 0.13405884919023206 6.7856542289960435 0.05479319043775677 0.020241051746437866 8.458609692486202e-09 8.07270101432516 0.26515605546154575 GEVPGGSAHYGGPS(ph)PEKK ddPTM_A459_Selumetinib_30min_R2 5 GEVPGGSAHYGGPSPEKK 18 1 J3KS37;O94762-4;O94762 J3KS37 RECQL5 ATP-dependent DNA helicase Q5 1 GEVPGGSAHYGGPS(1)PEKK;GEVPGGSAHYGGPS(1)PEKK;GEVPGGSAHYGGPS(1)PEKK;GEVPGGSAHYGGPS(1)PEKK;GEVPGGSAHY(0.005)GGPS(0.995)PEKK 159.26 8.2319e-06 47701400.0 163960.0 123990.0 162955.0 196556.0 191206.0 129032.0 144646.0 152937.0 113121.3 174846.0 True False 154847.75958388398 133499.63430931253 152470.65271198915 169784.73372198717 167184.99287667195 146804.9867641254 151372.32561061138 153382.02134991682 135748.7208732074 169797.74167553472 0.9119541759264469 0.786227384368963 0.8979545381901735 0.9999233914808336 0.9846125821634575 0.8645873927148807 0.8914860946729649 0.9033219160418129 0.7994730644451601 1.0 17.37345774548811 GEVPPKET(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 GEVPPKETPK 10 1 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GEVPPKET(1)PK 88.803 0.043931 97722000.0 7752.7 9993.7 9661.9 9795.6 6753.0 8225.2 6636.8 7070.7 6015.2 7355.0 True False 7933.322825871815 8823.632958054915 8349.867049017732 8084.982346185304 6142.192342338985 8142.461955884064 6136.180832681668 6883.162067129526 10207.355067174354 8299.085893766889 0.9559273066242412 1.0632054024988453 1.0061188853689276 0.9742015505897595 0.7401046839329787 0.9811275675553064 0.7393803258850843 0.8293879778132184 1.2299372723495596 1.0 13.018736723633062 -6.012897644834069 24.09248003439585 0.9010916220138216 1.0099401017564442 0.06972971354304447 0.13685978507495392 846.2277915444296 1580739.632554333 0.039321903884358994 0.05340714257943076 9.707387254261836e-07 6.012897644834069 0.10884847974262257 GEVPPKET(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GEVPPKETPK 10 1 P49006 P49006 MARCKSL1 MARCKS-related protein 1 GEVPPKET(1)PK 122.46 0.046203 33607000.0 39159.0 30694.0 28281.0 25541.0 26063.0 21234.0 30071.0 25065.0 14999.0 23925.0 True False 36982.69954589719 33048.13110323447 26461.4312500246 22062.271739317453 22788.73293382374 24158.790756939692 31469.361084556065 25137.935000265887 17999.21910707562 23234.22308538469 1.5917338578521643 1.422390194919973 1.1388989058416144 0.949559262568825 0.9808261223143209 1.0397933543186386 1.3544399986566207 1.081935682027548 0.7746856454347247 1.0 14.503963783829883 -5.190656221399475 2.2902439435959265 1.041003301322385 1.58189670203667 0.6642331335366333 0.13680914880759235 0.21843915561363186 2.086496151373108 0.04005366885284238 0.1639815804439104 6.446793785588315e-06 5.190656221399475 0.5408934007142852 GFAFVTFDDHDSVDK ddPTM_A459_Selumetinib_30min_R1 2 GFAFVTFDDHDSVDK 15 0 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8VZ49;Q32P51;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 ; 212.11 1.1577e-06 29531000.0 6401.3 7422.1 5398.7 5977.799999999999 10267.1 6178.9 10076.0 7008.0 2060.24 3941.9 False True 6550.4378352384665 6553.117081559322 4665.586192936381 4933.889447203489 9338.442617803732 6116.745875992322 9315.959207765864 6822.125074807832 3496.076806023955 4447.881262357541 1.4727096900438599 1.4733120546671086 1.0489457604053594 1.1092673468959342 2.0995260590328826 1.3752043984983136 2.0944712006156525 1.5337920849064783 0.7860094727823075 1.0 12.118902560022427 -8.255733206202443 24.346538841469457 0.8930046969146918 1.5274137795301002 0.367150763409992 0.3323655512106807 332.06241869823253 1416833.7611850651 0.2504582533246223 0.08867818291164725 5.549665327610639e-09 8.255733206202443 0.6344090826154084 GFAFVTFDDHDTVDK ddPTM_A459_Selumetinib_30min_R1 2 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 ; 172.85 5.0936e-05 26187000.0 7311.8 8934.7 6579.3 7310.9 8300.8 6755.3 8074.799999999999 6509.299999999999 3323.7 5661.0 False True 7482.150713713867 7888.621170370664 5685.8671975079815 6034.188557589743 7549.994105625273 6687.347815321649 7465.711334941221 6336.652218813724 5640.076146556628 6387.644492809569 1.1713473913797738 1.2349812484477982 0.8901351983361687 0.9446656845700002 1.1819684257826395 1.046919223956413 1.1687737699468417 0.9920170457117259 0.8829665071225454 1.0 12.641068305812471 -5.239128086976502 24.909650311456623 1.0234529128325809 1.203164360192132 0.376444731257232 0.09699296939445864 889.4555807914368 993037.427763523 0.026052615554594507 0.06880875846109157 5.7659638207097035e-06 5.239128086976502 0.17971144735955114 GFCFLEYEDHK ddPTM_A459_Selumetinib_30min_R1 2 GFCFLEYEDHK 11 0 O43390;B4DT28;O43390-4;O43390-3;O43390-2;O60506-2;O60506;O60506-4;O60506-3;B7Z645;O60506-5 O43390;O60506-2 HNRNPR;SYNCRIP Heterogeneous nuclear ribonucleoprotein R;Heterogeneous nuclear ribonucleoprotein Q 0 ; 169.58 0.00058057 35300000.0 13320.5 16193.7 18500.8 19107.5 15964.9 15169.8 15759.0 14644.4 9045.9 12280.5 False True 13630.841732818944 14297.734075753113 15988.492977620057 15770.733817197071 14520.877613832034 15017.20558507636 14570.285942356308 14255.98294028479 15350.231613604297 13856.821797199767 0.98369178245285 1.0318191490809563 1.1538355051120788 1.138120562421036 1.0479226641109336 1.083740976456166 1.0514882962051746 1.0288061107320934 1.1077743394741733 1.0 13.758308778207322 -7.297663780929786 8.611654051828312 1.049355765156353 1.0767732225510958 0.05311551010383264 0.052481798845439256 1.3356192099519728 299.14815698639853 0.02332130910193762 0.015817223831172296 5.0389055629825115e-08 7.297663780929786 0.027417457394742772 GFDNPEENS(ph)SEFPVTFK ddPTM_A459_Selumetinib_30min_R1 1 GFDNPEENSSEFPVTFK 17 0 Q8IWI9;Q8IWI9-3;H3BU53 Q8IWI9 MGA MAX gene-associated protein 1 GFDNPEENS(0.935)S(0.065)EFPVTFK 119.08 0.0014871 0.0 280.25 440.09 324.86 326.57 245.31 266.9 418.97 208.41 0.0 203.48 True False 286.7792797284268 388.5640582077096 280.7457963282483 269.54067997812643 223.12175381299812 264.2152283258105 387.3667555853176 202.88228978891263 0.0 229.59864006304363 1.2490460729631603 1.692362193874567 1.2227676795087312 1.1739646188850048 0.9717903980255846 1.1507700056640655 1.6871474303112322 0.8836389001834019 0.0 1.0 7.8429702865787725 -7.999692104315348 24.584250632510802 0.4806064950361305 1.2937852741876288 0.525776456300312 0.30982022443055957 5.825350032114077 465153.4048059523 0.16759878247101578 0.07923289091110071 1.0007092073823914e-08 7.999692104315348 0.8131787791514983 GFDQTINLILDESHER ddPTM_A459_Selumetinib_30min_R1 1 GFDQTINLILDESHER 16 0 F2Z2Y6;C9JIZ0;C9JNV3;O95777 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 88.992 0.018976 3831000.0 1240.4 1130.1 1349.1 1426.4 1422.9 1414.1 1278.8 1231.3 789.91 950.74 False True 1269.298906601751 997.7873666307634 1165.899630075847 1177.3060168441662 1294.1989462333984 1399.8754379000702 1182.3390864322128 1198.6419241739272 1340.4195772562339 1072.7767399918334 1.1831901823406552 0.9300978753867828 1.0868054708985604 1.0974380530035805 1.2064010133583345 1.3049084545874166 1.1021296811871717 1.1173265410126734 1.2494860554736094 1.0 10.067134146757768 -5.995383154326902 3.0050702067000765 1.1726363678361946 1.0535489114546228 0.16116310330657613 0.0978797720558843 0.38964258127941875 7.2100355692578955 0.028918967047914107 0.042951235687313224 1.0106873864669573e-06 5.995383154326902 -0.11908745638157181 GFEAKS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GFEAKSR 7 1 F5GXB6;F5H280;Q9NYS7;Q9NYS7-2 F5GXB6 WSB2 WD repeat and SOCS box-containing protein 2 1 GFEAKS(1)R 66.62100000000001 0.042633 2057100.0 9971.2 11172.0 10650.0 12694.0 11280.0 7231.5 13386.0 11765.0 8406.4 15073.0 True False 9417.040621876205 12028.8564763581 9964.790594843254 10965.055301628598 9862.905555520532 8227.573483978964 14008.4755238558 11799.234202199403 10087.914894440994 14637.803325642764 0.6433370098216353 0.8217665047654886 0.6807572402196959 0.7490915855126854 0.673796835228857 0.5620770617655283 0.9570066773144508 0.8060795694343901 0.6891686320698683 1.0 13.837411446218997 -7.267044801615561 24.99269191305419 0.8469036769374856 0.6962677673985527 0.4124646382544479 0.1010953745596384 554.8114549270396 2473704.8712219084 0.04131711495028637 0.02874023379058342 5.4069854185985195e-08 7.267044801615561 -0.1506359095389329 GFEGSCS(ph)QK ddPTM_A459_Selumetinib_30min_R2 2 GFEGSCSQK 9 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 GFEGS(0.232)CS(0.768)QK;GFEGS(0.062)CS(0.938)QK 85.958 0.034482 8227000.0 50036.0 31904.0 36018.0 39991.0 40058.0 48561.0 63156.0 57581.0 53613.0 40437.0 True False 47255.19942997809 34350.934212471235 33700.641093433274 34544.15681167709 35025.55591693631 55249.83695713234 66092.87914123978 57748.55117695227 64337.09807238118 39269.47874205644 1.2033569312283534 0.8747489223910275 0.858189163008698 0.8796693492822284 0.8919282108887528 1.40694093038626 1.6830597517062604 1.470570861311314 1.638348665002219 1.0 15.261120827534883 -6.810986029712527 5.084606099093001 1.4926342396997856 0.9288310980068432 0.609899236561257 0.19759017164649803 0.11757855221411445 6.568903158871677 0.06669826565592245 0.0598487614422251 1.5453041477360894e-07 6.810986029712527 -0.5638031416929424 GFFDPNTHENLTYLQLLER ddPTM_A459_Selumetinib_30min_R1 1 GFFDPNTHENLTYLQLLER 19 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;A0A075B730;P58107;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC;EPPK1 Plectin;Epiplakin 0 130.77 0.00039462 7962100.0 1301.9 1448.8 1935.9 1955.5 1729.4 1558.6 1366.1 1305.0 1031.6 1358.0 False True 1332.2317369435823 1279.1738224711537 1673.0154131375218 1614.0086342812451 1572.9760753503683 1542.921899095573 1263.0539771465799 1270.387160762588 1750.5498549170557 1532.3125280401684 0.8694255986065127 0.8347995588779922 1.0918238822189315 1.0533155637287428 1.0265373718259738 1.0069237644809796 0.8242796126988723 0.8290653097951346 1.1424235088360293 1.0 10.581494861735601 -5.2350405160760065 24.77728696127693 0.9879724578599179 0.8521125297746749 0.26001446617627155 0.09671988062203046 1044.0379296842175 979902.7144929863 0.026295527149184088 0.06952399246926902 5.820489148977962e-06 5.2350405160760065 -0.13585992808524305 GFFDPNTHENLTYR ddPTM_A459_Selumetinib_30min_R1 1 GFFDPNTHENLTYR 14 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 115.83 0.0038502 9915300.0 3880.6 4029.5 4714.0 5208.3 4651.7 4396.4 4632.9 4287.9 2356.3 3705.9 False True 3971.0104296668464 3557.724266736271 4073.8646921485006 4298.768176899517 4230.954556324338 4352.176207611817 4283.4366230308115 4174.170962937854 3998.469002657095 4181.58836352287 0.9496416395996908 0.8508069081527166 0.9742385758689037 1.0280227997568672 1.011805607943647 1.0407949872773299 1.0243563571193166 0.9982261762899188 0.9562081809718109 1.0 12.029835334362561 -5.466109476039538 5.358788268876851 1.0100906500700038 0.9011593936665763 0.6568428114206042 0.030891481769369535 0.11494638266642947 7.005241232861956 0.00809936598408859 0.016894197355697416 3.4189324791946462e-06 5.466109476039538 -0.10893125640342749 GFGDGYNGYGGGPGGGNFGGS(ph)PGYGGGR ddPTM_A459_Selumetinib_30min_R1 4 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 GFGDGYNGYGGGPGGGNFGGS(1)PGYGGGR;GFGDGYNGYGGGPGGGNFGGS(1)PGYGGGR;GFGDGYNGYGGGPGGGNFGGS(1)PGYGGGR;GFGDGYNGYGGGPGGGNFGGS(1)PGYGGGR 156.7 2.2844e-17 146428100.0 6737.86 8156.6 8197.4 8994.7 8713.7 6673.200000000001 7846.2 8078.099999999999 4020.58 6521.3 True False 6894.839028406706 7201.621480099538 7084.238105095056 7423.944496430326 7925.547373528684 6606.073666780818 7254.354816988142 7863.842546633149 6822.630608455227 7358.372377841198 0.9370059945823939 0.9786976127745729 0.9627452568761453 1.0089112259100381 1.0770788656191772 0.8977628920594136 0.9858640531476375 1.068693203175489 0.9271928978479957 1.0 12.845170971855161 -4.725456051039054 1.252266607821055 0.9949210337928321 0.9095930764488093 0.09023500864667466 0.052301218597307006 4.183841065251157 5.190705250968298 0.015675937112511498 0.4792521521067415 1.881672114693551e-05 4.725456051039054 -0.08532795734402288 GFGDGYNGYGGGPGGGNFGGS(ph)PGYGGGR ddPTM_A459_Selumetinib_30min_R2 4 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 GFGDGYNGYGGGPGGGNFGGS(1)PGYGGGR;GFGDGYNGYGGGPGGGNFGGS(1)PGYGGGR;GFGDGYNGYGGGPGGGNFGGS(0.999)PGY(0.001)GGGR;GFGDGYNGYGGGPGGGNFGGS(0.999)PGY(0.001)GGGR 121.66 2.6027e-12 114909000.0 262070.0 254394.0 284420.0 324086.0 330747.0 248014.0 254405.0 271904.0 236033.0 293849.0 True False 247505.19854933195 273905.2017943644 266120.7268530814 279944.92772046704 289195.60494430404 282175.67725306744 266235.3365939439 272695.19562386983 283246.1953130468 285364.8158586079 0.8673290636921598 0.9598422320223194 0.9325632035343084 0.9810071605294667 1.013424181513653 0.9888243454402571 0.9329648288731494 0.9556020240385361 0.9925757471565422 1.0 18.12244794269334 -3.6189508645160475 1.013343762594651 0.9762110714170465 1.4015484666816992e-11 0.623945043510957 0.025150169076212463 11.933224565708594 1.5679995896801777 0.008483994514630118 21.622264506025655 0.00024046348417160115 3.6189508645160475 -0.9762110714030311 GFGFGQGAGALVHS(ph)E ddPTM_A459_Selumetinib_30min_R1 8 GFGFGQGAGALVHSE 15 0 E9PP21;P21291 E9PP21 CSRP1 Cysteine and glycine-rich protein 1 1 GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E 209.25 1.4411e-06 623750900.0 19987.9 24239.36 24357.34 28851.22 25974.210000000003 21738.760000000002 23399.91 20545.97 12917.810000000001 17595.72 True False 20453.57918031696 21401.40446262727 21049.747013291548 23812.89603147417 23624.84729161924 21520.087811614827 21634.835949324377 20001.024132883766 21920.5800904867 19854.3020588269 1.0301837415243529 1.0779227796180604 1.060210877769595 1.1993821772690996 1.1899107418442856 1.0839004941021004 1.0896800041231307 1.007389938645143 1.1040720557961476 1.0 14.277164026034233 -7.496703694164214 2.8245824206017103 1.0419599813579703 1.111395557135725 0.22397924461298446 0.05667320069772833 0.4573449319371131 7.3163096573478095 0.03143057469600692 0.01790081302208531 3.186370743537249e-08 7.496703694164214 0.06943557577775472 GFGFGQGAGALVHS(ph)E ddPTM_A459_Selumetinib_30min_R2 4 GFGFGQGAGALVHSE 15 0 E9PP21;P21291 E9PP21 CSRP1 Cysteine and glycine-rich protein 1 1 GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E;GFGFGQGAGALVHS(1)E 185.2 2.1287e-05 298802000.0 412193.0 419630.0 468457.0 466361.0 526580.0 343822.0 370644.0 398361.0 347420.0 437688.0 True False 389284.96319931623 451814.27167688287 438316.9866374172 402841.8272824018 460426.3127150709 391180.3595946366 387879.6804171524 399520.16455778613 416913.7077258621 425050.81019000395 0.9158551257090891 1.0629653228396747 1.0312108014603787 0.9477498163156672 1.0832265265163326 0.9203143488181407 0.9125489732480795 0.9399350735955421 0.9808561652652669 1.0 18.697275784458085 -6.796969959388972 24.99999848911123 0.9445904693698962 1.0091639826350052 0.22759549315605532 0.05231372106215598 239.8971535601091 168794.5160138709 0.01778595031094142 0.015686348942029586 1.5959895397119259e-07 6.796969959388972 0.06457351326510896 GFGFVDFNS(ph)EEDAK ddPTM_A459_Selumetinib_30min_R1 3 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 1 GFGFVDFNS(1)EEDAK;GFGFVDFNS(1)EEDAK;GFGFVDFNS(1)EEDAK 225.31 1.0095e-09 20640300.0 5508.59 7051.3 6854.4 7722.700000000001 6287.83 5531.83 5924.41 6196.44 3499.3 5320.27 True False 5636.929429149745 6225.7305179395635 5923.610128524114 6374.075418033123 5719.096886706553 5476.184812699772 5477.526983930143 6032.090282326235 5938.056521240063 6003.17847831831 0.9389908112025409 1.0370723676507445 0.9867456298223394 1.0617834270719058 0.9526781366508134 0.9122142265931485 0.9124378033592264 1.0048160826989145 0.9891520871296018 1.0 12.551510845506629 GFGFVDFNS(ph)EEDAK ddPTM_A459_Selumetinib_30min_R2 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 1 GFGFVDFNS(1)EEDAK 83.87700000000002 0.02688 746190.0 4439.9 4371.6 4149.0 2539.2 4066.8 3434.9 4538.0 3867.0 2990.2 5315.9 True False 4193.148132327919 4706.8876630905 3882.057857089642 2193.356579635679 3555.892226346713 3908.026296082326 4749.025991876406 3878.252329783689 3588.323553168714 5162.416154633078 0.8122452756089265 0.9117606024199041 0.7519846794229555 0.42487016039325354 0.6888038700939348 0.757014967221311 0.9199231231318556 0.7512475193041346 0.6950860693298285 1.0 12.33383072985715 -7.009292681884478 21.519413382619007 0.8233539996141825 0.7151713246713717 0.14310016983753215 0.1402060410307553 177.7676380794059 411665.5819765867 0.055655965461749224 0.04639779550892815 9.788301050548394e-08 7.009292681884478 -0.10818267494281086 GFGFVDFNSEEDAK ddPTM_A459_Selumetinib_30min_R2 2 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 ; 150.21 0.0058904 3616300.0 18840.7 18752.6 17984.6 21780.3 16796.9 15104.2 15794.7 15756.1 11920.0 16399.5 False True 17793.609319297877 20190.86412088728 16827.490416151933 18813.785566886825 14686.723255808765 17184.666447723863 16529.184846604294 15801.947642437222 14304.333072627604 15926.003823981864 1.1172676784432085 1.267792243681573 1.0566046951974597 1.1813249434586002 0.9221850891240556 1.079031917714767 1.0378739719824845 0.9922104639107373 0.8981746601798313 1.0 13.959096688686525 -6.013217535651193 0.8087220687314733 0.9811265169116037 1.1991305221561672 0.5027021197235158 0.07568606003233003 0.6105609983060606 0.8013264108468218 0.03664124224439043 0.08681544957773589 9.700239660163722e-07 6.013217535651193 0.21800400524456354 GFGFVTFDDHDPVDK ddPTM_A459_Selumetinib_30min_R1 2 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 160.48 0.00018073 153110000.0 8274.2 10977.6 8445.0 9353.5 8465.5 8312.9 9825.9 9821.2 5855.5 8580.1 False True 8466.972761209461 9692.337488652212 7298.215385064503 7720.0868119404895 7699.79701970542 8229.279773509295 9084.724452122524 9560.709872246383 9936.35583120087 9681.43941225143 0.8745572223996863 1.0011256669526838 0.7538357752700426 0.7974110546176701 0.7953153133367411 0.8500058124720079 0.9383650576407275 0.9875297943968674 1.02633042547649 1.0 13.241005844407306 -7.493018407372128 2.203325373434927 1.0081867105143298 0.8431807057739198 0.5725409101650307 0.06245563345920486 0.2575994892561929 2.471639236171988 0.038454838896788635 0.020724099794914505 3.2135243320010865e-08 7.493018407372128 -0.16500600474041005 GFGFVTFDDHDPVDK ddPTM_A459_Selumetinib_30min_R2 2 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 154.13 0.00052009 1429700.0 67702.0 58956.0 58464.1 64329.0 70756.0 50529.9 54419.9 57727.8 54208.6 59569.0 False True 63939.39387257924 63477.73562658147 54702.58345689911 55567.27922628534 61866.99871333425 57489.93506023766 56950.53318098613 57895.77834064826 65051.834714835604 57849.08819115069 1.1052791992382724 1.0972988099109193 0.9456083953500773 0.9605558352566325 1.069455036333627 0.9937915507029899 0.984467257164098 1.000807102600188 1.1245092489597224 1.0 15.820006599513638 -5.1600205658784315 8.411794436019997 1.0088685817218683 1.1026955464714043 0.35427401972318995 0.04936077194429892 0.3427642850510825 25.733903185756454 0.012707350999530688 0.033921575884008806 6.917982102568573e-06 5.1600205658784315 0.093826964749536 GFGQSNS(ph)LPTAGSVGGGMGR ddPTM_A459_Selumetinib_30min_R2 2 GFGQSNSLPTAGSVGGGMGR 20 0 G3V2R1;Q9UPU9-2;Q9UPU9-3;Q9UPU9 G3V2R1 SAMD4A Protein Smaug homolog 1 1 GFGQS(0.001)NS(0.989)LPT(0.01)AGSVGGGMGR;GFGQS(0.052)NS(0.787)LPT(0.16)AGS(0.001)VGGGMGR 140.27 6.910899999999999e-05 9677700.0 21127.1 23734.0 23953.0 27374.0 36101.0 26818.0 24010.0 22418.0 22363.0 29207.0 True False 19952.94036048226 25554.32148316174 22411.890058054523 23645.613977216086 31565.66963296516 30511.9360704346 25126.512574912416 22483.232668500303 26836.22487442711 28363.718021100532 0.7034670259251178 0.9009510482423776 0.7901605156764608 0.8336570670892116 1.1128889946474088 1.075738238821016 0.8858680852848745 0.7926757927777459 0.9461462299992871 1.0 14.791759038326587 -6.029071790293403 24.545240340465693 0.9609445768830882 0.8090420035920036 0.40693019094122196 0.09586956260215716 668.7674822843741 564637.9736588296 0.0310119493189258 0.04011728276192636 9.352510613200971e-07 6.029071790293403 -0.15190257329108459 GFGS(ph)EEGSR ddPTM_A459_Selumetinib_30min_R1 2 GFGSEEGSR 9 0 Q9Y5S9 Q9Y5S9 RBM8A RNA-binding protein 8A 1 GFGS(0.999)EEGS(0.001)R;GFGS(0.996)EEGS(0.004)R 107.45 0.012579 89649000.0 6169.6 7594.799999999999 6919.1 8345.0 6841.0 6507.5 6800.3 6614.200000000001 3311.9 5374.200000000001 True False 6313.339676048182 6705.597285273271 5979.524223895777 6887.702405050871 6222.232757876648 6442.04045833725 6287.347896047064 6438.76993005051 5620.052408394526 6064.030919140998 1.0411127120279426 1.105798663411689 0.9860642703884512 1.1358290379605371 1.0260885607024677 1.0623363475939862 1.0368264904786633 1.0617970152043017 0.9267849196901252 1.0 12.566061394170047 -8.248870081089237 24.648092589608 0.9633924615764387 1.0573500930448068 0.43807559180270206 0.04239681020569581 466.3804306020019 914566.0406728904 0.026612239865287057 0.00989557142651043 5.6380629288533965e-09 8.248870081089237 0.09395763146836811 GFGS(ph)EEGSR ddPTM_A459_Selumetinib_30min_R2 2 GFGSEEGSR 9 0 Q9Y5S9 Q9Y5S9 RBM8A RNA-binding protein 8A 1 GFGS(0.944)EEGS(0.056)R;GFGS(0.621)EEGS(0.379)R 97.813 0.020257 91209000.0 192536.0 173406.0 204732.0 198001.0 218725.0 136597.0 162025.0 160358.8 138084.0 155949.0 True False 181835.61990267536 186705.68261182925 191559.76601534765 171032.92222922342 191246.81007369037 155411.99684589298 169559.4835464466 160825.41755917168 165704.65838932153 151446.34716583692 1.2006603216620442 1.232817338323668 1.2648688436544837 1.1293301253541546 1.262802396047698 1.0261851788060203 1.1196010119727444 1.0619299875424824 1.0941476073230836 1.0 17.208447255678145 -6.762482603236222 24.99999998028209 1.0679451379901106 1.2165807499429535 0.7347011539182938 0.04727524086659077 14.827361683118918 355319.5155512183 0.01547307057015549 0.014423579090734882 1.727895194333341e-07 6.762482603236222 0.14863561195284292 GFGS(ph)LPCILNACSGDAK ddPTM_A459_Selumetinib_30min_R1 1 GFGSLPCILNACSGDAK 17 0 Q8WWL2-4;Q8WWL2-3;Q8WWL2-2;Q8WWL2 Q8WWL2-4 SPIRE2 Protein spire homolog 2 1 GFGS(1)LPCILNACSGDAK 226.22 3.6001e-16 8917300.0 4500.9 5035.0 5855.9 6832.8 5546.7 5011.1 5193.6 5128.5 2764.8 4559.0 True False 4605.762212773153 4445.499859292006 5060.700944156215 5639.579747541234 5045.001964349419 4960.6928837147625 4801.842570608649 4992.475520284242 4691.663666997552 5144.192058420562 0.895332476017094 0.86417843828656 0.9837698294861135 1.0963003876011528 0.980718042222242 0.9643288639650558 0.933449318391696 0.9705072173796516 0.9120312021239054 1.0 12.328728791355633 -5.265924959534562 24.661245005917067 0.9810220894440113 0.8797554529328515 0.42782349610867443 0.04642662510664381 286.4574582356493 1574923.5733631898 0.013134174249723594 0.028945106770729406 5.420945492316996e-06 5.265924959534562 -0.10126663651115975 GFGS(ph)LPCILNACSGDAK ddPTM_A459_Selumetinib_30min_R2 2 GFGSLPCILNACSGDAK 17 0 Q8WWL2-4;Q8WWL2-3;Q8WWL2-2;Q8WWL2 Q8WWL2-4 SPIRE2 Protein spire homolog 2 1 GFGS(1)LPCILNACSGDAK;GFGS(0.999)LPCILNACS(0.001)GDAK 133.93 0.0005918 7106100.0 75990.0 70178.0 71953.0 82767.0 80170.0 62140.0 63689.0 76009.0 60086.0 72794.0 True False 71766.7800120721 75560.4269421641 67323.62231650307 71493.99181896124 70098.32787110643 70699.22094924332 66650.6646973592 76230.17360603258 72104.87894311266 70692.24807847409 1.0152001381029103 1.0688643945554812 0.9523480175898271 1.0113413247177703 0.9915985101123342 1.0000986369928635 0.9428284784969858 1.0783385120446438 1.019982825600205 1.0 16.10926440120498 -10.110100597535949 4.297611361449271 1.0000000073070316 1.0084476573811445 0.004208872013606313 0.040655367747041274 5384913.330550043 13373315.078540297 0.665223620538502 0.010143318429768131 7.760673319268923e-11 10.110100597535949 0.008447650074112856 GFGS(ph)VEELCTNSSLGMEK ddPTM_A459_Selumetinib_30min_R1 2 GFGSVEELCTNSSLGMEK 18 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 GFGS(1)VEELCTNSSLGMEK;GFGS(1)VEELCTNSSLGMEK 290.92 8.520699999999997e-81 30209000.0 2821.3999999999996 3850.6 4064.7 3867.1000000000004 3904.0 3076.5 3323.4 3179.7 1693.8899999999999 2657.8999999999996 True False 2887.133130511272 3399.769961904627 3512.7360657988997 3191.783579457428 3550.8838893071825 3045.5532032385026 3072.71326231531 3095.3640268787763 2874.407613169301 2999.067355138411 0.9626769887527341 1.1336090721936196 1.1712761501606161 1.0642587182941488 1.1839960457117857 1.0155001013966711 1.0245562698185884 1.0321088726384808 0.9584338305188358 1.0 11.5502982082802 -6.8842322438612085 9.740689732180938 1.0084210969823582 1.1063985390471263 0.3898329594674208 0.06066160794335166 0.3161117723174216 25.569845712731624 0.021077942991754698 0.01859294111618198 1.3054725852806829e-07 6.8842322438612085 0.0979774420647681 GFGS(ph)VEELCTNSSLGMEK ddPTM_A459_Selumetinib_30min_R2 3 GFGSVEELCTNSSLGMEK 18 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 GFGS(1)VEELCTNSSLGMEK;GFGS(1)VEELCTNSSLGMEK;GFGS(1)VEELCTNSSLGMEK 210.98 1.0343e-11 8970100.0 29205.0 31845.9 29385.7 28695.9 30636.8 24491.1 27070.4 29822.6 24120.8 27006.1 True False 27581.90301687805 34288.37812929216 27495.05605473104 24787.468916811402 26787.93128753292 27864.526716929708 28329.227238979965 29909.378828602778 28945.633991462728 26226.3637227255 1.0516861318817887 1.307401151444446 1.0483746944646468 0.9451355582067492 1.0214123303842086 1.0624624523446504 1.0801812839357638 1.1404317863053923 1.1036846090249617 1.0 14.678730171793777 -5.3366006061731595 24.999811812075414 1.0519523661196706 1.179545631036571 0.31127876301853985 0.0769166072139307 135.58535719947903 45097.0844762468 0.020397238989528343 0.042460250953082965 4.606800378284421e-06 5.3366006061731595 0.12759326491690048 GFGSEEGS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 GFGSEEGSR 9 0 Q9Y5S9 Q9Y5S9 RBM8A RNA-binding protein 8A 1 GFGS(0.01)EEGS(0.99)R;GFGS(0.224)EEGS(0.776)R 106.88 0.012912 109340000.0 58336.0 47085.0 62304.0 61241.0 71596.0 40012.0 45211.0 51426.0 43914.0 49016.0 True False 55093.918657510636 50696.26809786257 58295.42847146614 52899.87015338245 62601.470403639025 45523.289807227564 47313.40108389692 51575.64114596742 52698.02705967859 47600.78072113757 1.1574162823141612 1.0650301808043754 1.2246737887132912 1.1113235823439294 1.3151353707910984 0.9563559487378854 0.9939627116848309 1.0835041015002675 1.1070832507643629 1.0 15.538697615546463 -6.781924088213523 24.999836408486615 1.0312615680045132 1.167875915124003 0.49146712819693983 0.07433289904496765 229.6071020171684 280214.06967970537 0.02639492499829856 0.023304709786793852 1.6522505753998006e-07 6.781924088213523 0.13661434711948983 GFGSSAPEGLEPDS(ph)MASAASALHLLSPRPR ddPTM_A459_Selumetinib_30min_R2 1 GFGSSAPEGLEPDSMASAASALHLLSPRPR 30 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.439)MAS(0.139)AAS(0.207)ALHLLS(0.215)PRPR 57.051 0.0026184 3620900.0 9544.3 8140.8 10792.0 8696.5 13757.0 7415.6 7471.6 6529.3 8761.6 9469.0 True False 9013.866014860105 8765.173183202289 10097.654469441173 7512.021697700733 12028.72267085958 8437.031587885553 7819.044204694526 6548.299182016193 10514.16481955822 9195.605366583386 0.9802362819544521 0.9531915337574971 1.0980956736286023 0.8169143192028709 1.308094702994941 0.9175069233120342 0.8503022795115533 0.7121118100405395 1.1433901739374819 1.0 13.166728838159504 -6.9681622315841025 24.99999245332612 0.8998090437162286 1.0281699973093374 0.09539069553274526 0.1558354836469351 393.0203551669549 308610.6035784223 0.05297935463235765 0.04672308888429357 1.0760631729633365e-07 6.9681622315841025 0.12836095359310884 GFGSSAPEGLEPDSMAS(ph)AASALHLLSPR ddPTM_A459_Selumetinib_30min_R2 1 GFGSSAPEGLEPDSMASAASALHLLSPR 28 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.014)MAS(0.776)AAS(0.029)ALHLLS(0.181)PR 75.956 0.00018251 3047700.0 10340.0 9392.8 10941.0 13160.0 15514.0 12890.0 12538.0 14624.0 14143.0 14521.0 True False 9765.34419429958 10113.197557387775 10237.067971660106 11367.58529773375 13564.992623080276 14665.48049623022 13121.041843575671 14666.553418866477 16971.995188437264 14101.740999911015 0.6924920968525234 0.7171595023232658 0.7259435534750428 0.806112188403225 0.9619374390130888 1.0399765884455516 0.930455455369551 1.0400526728550061 1.2035389948336421 1.0 13.78358566819354 -6.227095831677661 1.0746337834292132 1.055335292092773 0.688058564759738 0.8459617812143024 0.06332444546254226 0.1977866367484527 0.47563276030317214 0.02850158686222249 0.044897026754828796 5.927945037606481e-07 6.227095831677661 -0.36727672733303496 GFGSSAPEGLEPDSMAS(ph)AASALHLLSPRPR ddPTM_A459_Selumetinib_30min_R2 1 GFGSSAPEGLEPDSMASAASALHLLSPRPR 30 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.219)MAS(0.485)AAS(0.148)ALHLLS(0.148)PRPR 45.14 0.016878 51137000.0 40955.0 42557.0 57303.0 47778.0 54522.0 54075.0 35627.0 57421.0 47774.0 60166.0 True False 38678.88505585486 45820.98505767737 53616.18736678904 41270.55397835286 47672.45892713568 61523.34040602399 37283.72609356121 57588.08560344174 57330.13491708989 58428.85124995843 0.6619826374882285 0.78421848243525 0.9176320639510637 0.7063386168897547 0.8159061475159431 1.052961663456763 0.6381047255928677 0.985610436821359 0.9811956540413872 1.0 15.834393304768053 -1.8162225707034192 0.12223030733052634 1.0702737293936795 3.0032148714942257e-18 0.3285617778473927 0.11875987587754784 109.35782090194955 0.9846501801167032 0.7956400471934424 19.76958861604082 0.015267833995574335 1.8162225707034192 -1.0702737293936795 GFGSSAPEGLEPDSMASAAS(ph)ALHLLSPRPR ddPTM_A459_Selumetinib_30min_R1 1 GFGSSAPEGLEPDSMASAASALHLLSPRPR 30 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.004)MAS(0.086)AAS(0.455)ALHLLS(0.455)PRPR 66.925 0.00018544 45597000.0 3004.3 4275.3 2760.4 3963.0 3899.6 3728.4 5061.2 4236.1 1699.0 2496.3 True False 3074.294344649824 3774.7458884669536 2385.5528417918376 3270.9364447233825 3546.8818685303 3690.895681116345 4679.429609204505 4123.744867207972 2883.078909949666 2816.7244210211147 1.0914430683053244 1.3401189908022804 0.8469244715558757 1.1612554001777737 1.259222180934722 1.3103502968097698 1.6613018917584155 1.4640214131111335 1.0235573236889453 1.0 11.45980270677949 -6.3753885918437465 2.6550835070774514 1.3404808950624625 1.1052377925893657 0.12393295012329608 0.2143388357707996 0.4880574568877936 6.6944720209725475 0.07294372991070551 0.08528827828538131 4.2131935258095597e-07 6.3753885918437465 -0.23524310247309677 GFGSSAPEGLEPDSMASAAS(ph)ALHLLSPRPR ddPTM_A459_Selumetinib_30min_R2 1 GFGSSAPEGLEPDSMASAASALHLLSPRPR 30 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.101)MAS(0.128)AAS(0.434)ALHLLS(0.338)PRPR 73.655 4.5676e-05 4858900.0 9172.8 9514.2 12171.0 13429.0 14343.0 8765.7 8280.1 11828.0 11496.0 13605.0 True False 8663.012497627771 10243.908547025261 11387.931110782849 11599.94703368288 12541.104111953113 9973.095607898005 8665.141056706881 11862.417521769194 13795.521225077759 13212.188299964828 0.6556833963417577 0.7753377649826965 0.861926189079001 0.877973184329636 0.9492071886370631 0.7548405594495315 0.6558445020595074 0.8978389690223211 1.0441511210610346 1.0 13.689581815706173 -3.330989414712422 0.046266570675279214 1.4206347312844922 3.567554356777999e-08 0.3458989155214347 0.10333889792065601 580.8567104570213 2.8898826428355395 26.79931694312962 71.01748850187 0.0004666707545871546 3.330989414712422 -1.4206346956089486 GFGSSAPEGLEPDSMASAASALHLLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 GFGSSAPEGLEPDSMASAASALHLLSPR 28 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDSMAS(0.001)AAS(0.008)ALHLLS(0.991)PR;GFGSSAPEGLEPDSMAS(0.001)AAS(0.036)ALHLLS(0.962)PR 121.04 2.6231e-12 127122000.0 3781.2 5072.9 4018.0 3724.2 5087.4 4099.4 6156.7 5447.7 2087.41 3970.5 True False 3869.294603065578 4478.962509672771 3472.377669294159 3073.8383818922057 4627.245568253422 4058.1637579573917 5692.295162212392 5303.209299376518 3542.1823116056707 4480.152350945132 0.8636524608921642 0.9997344194618495 0.7750579438580091 0.6861013066316259 1.0328321909136102 0.9058093207703712 1.2705583909465816 1.1837118213753945 0.7906388073741316 1.0 12.129332077707424 -6.623421778502198 2.2497961037798304 1.0648973374861932 0.8435708287072932 0.26860357946876146 0.14917570971177296 0.3948637215555177 4.07320018494653 0.056827237742709515 0.057269255074853004 2.3800069293412097e-07 6.623421778502198 -0.22132650877890003 GFGSSAPEGLEPDSMASAASALHLLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 GFGSSAPEGLEPDSMASAASALHLLSPR 28 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDSMASAAS(0.002)ALHLLS(0.998)PR;GFGSSAPEGLEPDSMASAAS(0.006)ALHLLS(0.994)PR;GFGSSAPEGLEPDS(0.006)MAS(0.094)AAS(0.063)ALHLLS(0.837)PR;GFGSSAPEGLEPDS(0.037)MAS(0.047)AAS(0.057)ALHLLS(0.858)PR;GFGSSAPEGLEPDS(0.012)MAS(0.003)AAS(0.005)ALHLLS(0.98)PR;GFGSSAPEGLEPDSMASAAS(0.006)ALHLLS(0.994)PR 116.51 2.7733e-12 91013000.0 61645.200000000004 55082.6 68073.29999999999 84442.1 87149.29999999999 62735.299999999996 82260.29999999999 84617.4 84386.9 85380.29999999999 True False 58219.206569287824 59307.25830152548 63693.53799060495 72940.9403092525 76200.8258093728 71376.51812064798 86085.56694569207 84863.62262483523 101266.6379669899 82915.14889433922 0.702154037538761 0.7152765096894677 0.7681773335747267 0.8797058352051313 0.9190217568863968 0.8608380865552663 1.0382368975227072 1.0234996108247842 1.2213285427013636 1.0 16.339348090897758 -6.450732312439779 0.553175138165189 1.1040886199005715 0.6722936360763018 0.8045945258157228 0.06832727821938842 0.4302535312450843 0.27889828394972693 0.054687033113916594 0.09150430801056375 3.5421560288157435e-07 6.450732312439779 -0.43179498382426973 GFGSSAPEGLEPDSMASAASALHLLS(ph)PRPR ddPTM_A459_Selumetinib_30min_R1 1 GFGSSAPEGLEPDSMASAASALHLLSPRPR 30 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.063)MAS(0.157)AAS(0.132)ALHLLS(0.648)PRPR 40.931 0.031305 44881000.0 1299.2 1336.7 1312.5 1510.0 1579.0 1490.0 2064.8 1339.0 613.28 1135.9 True False 1329.4688321968688 1180.1985425850285 1134.2697090464371 1246.3068462105243 1436.1797287950926 1475.0119528117564 1909.0504736199832 1303.4853703150243 1040.6913678010187 1281.7038296029643 1.037266801807638 0.9208044130995697 0.8849702114082018 0.9723828683546923 1.1205238648931717 1.1508212105979847 1.489463033134069 1.0169942074050033 0.8119593183422067 1.0 10.323847213602635 -6.219027642542285 4.321274040058561 1.1220030808257824 0.9433493403024895 0.1476402148538717 0.16456694388847232 0.3876411122625009 16.329710329352846 0.05364530990365371 0.06845333168122211 6.039101896887254e-07 6.219027642542285 -0.17865374052329286 GFGSSAPEGLEPDSMASAASALHLLS(ph)PRPR ddPTM_A459_Selumetinib_30min_R2 1 GFGSSAPEGLEPDSMASAASALHLLSPRPR 30 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GFGSSAPEGLEPDS(0.01)MAS(0.001)AAS(0.021)ALHLLS(0.968)PRPR 97.049 4.4639e-08 64666000.0 72724.0 72756.0 114070.0 121050.0 138790.0 93810.0 79786.0 108920.0 79451.0 156400.0 True False 68682.29121723812 78336.15125258776 106730.86039002528 104562.78117710263 121353.95940165746 106731.47597760722 83496.20709295975 109236.93916732343 95343.42004642102 151884.32562399886 0.4522013113273211 0.5157619190179955 0.7027114875187688 0.6884369453366486 0.7989893552418198 0.7027155405214693 0.549735509243139 0.7192114045905418 0.6277370601259465 1.0 17.212613466651213 -14.522878745280336 0.1434520398577029 2.1560828829637613 0.5325260728271407 0.5692679898709615 0.09680951895940754 116.92556791161375 1.0132295543367835 39.12080710773119 0.6110194533048305 3.0000000000000132e-15 14.522878745280336 -1.6235568101366207 GFGSVEELCT(ph)NSSLGMEK ddPTM_A459_Selumetinib_30min_R1 2 GFGSVEELCTNSSLGMEK 18 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 GFGS(0.102)VEELCT(0.493)NS(0.389)S(0.016)LGMEK;GFGS(0.012)VEELCT(0.856)NS(0.122)S(0.01)LGMEK 134.93 0.0037072 10936800.0 2868.44 3831.2 3940.7000000000003 4287.4 3400.7 2994.0 3575.3 3237.63 1812.3799999999999 3234.5 True False 2935.2690709873655 3382.6413229234404 3405.5745847156536 3538.6860744655623 3093.107285442351 2963.8830783344947 3305.612242509456 3151.7575350956163 3075.4764890021042 3649.679581698027 0.8042539092217297 0.9268324101343861 0.9331160471712416 0.9695881502066479 0.8475010521343551 0.8120940515428856 0.9057266997042813 0.8635710243991472 0.8426702728712495 1.0 11.833554094904974 -3.1884758695127746 15.346989701097227 0.8881811945386376 0.3906087336344082 0.0 0.06333739881528455 0.0 0.0 0.014404554573096858 0.0 0.0006479240945512804 3.1884758695127746 -0.49757246090422946 GFIDQNLS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 GFIDQNLSPTK 11 0 F8WAY9;C9JTZ9;Q14188 F8WAY9 TFDP2 Transcription factor Dp-2 1 GFIDQNLS(0.514)PT(0.486)K;GFIDQNLS(0.5)PT(0.5)K 112.44 0.0076726 21664000.0 2900.9 4459.5 2980.8 3161.7 2933.3 2885.6 3382.7 3142.8 1754.75 2892.6 True False 2968.4853258312 3937.379666834694 2576.023732362377 2609.568447459477 2667.983532916178 2856.5734839151723 3127.5402155726065 3059.442734746867 2977.6825881307686 3263.8933863100087 0.9094921232054145 1.206344448427617 0.7892487368512664 0.7995262524214131 0.8174236156446469 0.8752042869711099 0.9582237669559556 0.9373598866860405 0.9123100039420051 1.0 11.672378217720913 -5.273041398342738 24.99885691189885 0.8805581249625427 1.0579182997495944 0.34916520746730184 0.09354774809790582 682.4449178947791 1470464.0975810895 0.024441644698304656 0.05156394190930043 5.3328405871805094e-06 5.273041398342738 0.17736017478705168 GFIDQNLS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 GFIDQNLSPTK 11 0 F8WAY9;C9JTZ9;Q14188 F8WAY9 TFDP2 Transcription factor Dp-2 1 GFIDQNLS(0.957)PT(0.043)K 84.169 0.036701 9920600.0 58236.0 47213.0 51129.0 51464.0 53117.0 53271.0 56336.0 52901.0 36457.0 47216.0 True False 54999.47625717891 50834.08528627771 47839.41580504607 44454.514419648185 46443.967587995045 60608.596704009295 58955.73562766626 53054.93315176798 43749.41869368997 45852.75139809918 1.1994803927831232 1.1086376223082008 1.0433270490073414 0.9695059307060697 1.0128937996492915 1.3218093757950982 1.2857622242950129 1.1570719648018193 0.9541285388493306 1.0 15.48472068500114 GFIDQNLSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GFIDQNLSPTK 11 0 F8WAY9;C9JTZ9;Q14188 F8WAY9 TFDP2 Transcription factor Dp-2 1 GFIDQNLS(0.261)PT(0.739)K 158.34 0.0013376 7453700.0 77641.0 57877.0 68089.0 64535.0 72619.0 59006.0 73242.0 76002.0 57681.0 59002.0 True False 73326.02404154863 62315.97979611326 63708.22786969786 55745.22167091548 63495.951997902914 67133.5408968627 76647.89812626962 76223.15323719151 69218.81174179808 57298.458954393594 1.2797207006895612 1.0875681638438712 1.1118663404264693 0.9728921630385486 1.1081616007935253 1.171646535036785 1.3376956296028328 1.3302827794698793 1.2080396751488975 1.0 15.806208717680823 -6.978424589059836 4.358479483262022 1.248069377840229 1.1043794524616688 0.14593609778107586 0.11250511777330606 0.2856749825054618 12.952861679416948 0.04144467928660266 0.03490855156163321 1.0509339233017193e-07 6.978424589059836 -0.14368992537856018 GFLS(ph)PGSR ddPTM_A459_Selumetinib_30min_R1 1 GFLSPGSR 8 0 Q5UIP0;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 GFLS(1)PGSR 112.11 0.011314 11753000.0 5387.4 8341.5 6373.4 7092.6 6999.1 6696.6 6909.9 6346.9 3613.1 5273.6 True False 5512.915937944429 7364.873302141858 5507.9272865802395 5854.010554591232 6366.032640791466 6629.238284026318 6388.680679807591 6178.559594363275 6131.166809616921 5950.517929214016 0.9264598482896449 1.2376860955218836 0.9256214924652388 0.9837816849271251 1.069828326965874 1.1140607192325447 1.0736343887718445 1.038322994378303 1.0303585137549138 1.0 12.538799529786726 -4.501993373858513 19.451617438251997 1.0526259950418286 0.6049526830080707 0.18494302467223123 0.07943445952958132 5587358.483136132 125194082.16324233 0.019353230838953902 78522591.57162085 3.147796340465175e-05 4.501993373858513 -0.44767331203375793 GFNGCDSPEPDGEDS(ph)LEQSPLLEDKYR ddPTM_A459_Selumetinib_30min_R1 1 GFNGCDSPEPDGEDSLEQSPLLEDKYR 27 1 Q14814-4;Q14814;Q05BX2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 GFNGCDS(0.007)PEPDGEDS(0.993)LEQSPLLEDKYR 130.3 3.3629e-12 7254000.0 768.75 633.7 787.06 687.62 852.67 742.99 759.07 705.47 323.36 600.68 True False 786.6603792728931 559.5061094008628 680.1815750111158 567.5400752260135 775.546149051115 735.5161951809439 701.8127387692367 686.7586439104855 548.7183027200259 677.7831291186801 1.1606372975022052 0.8254942995237833 1.0035386627217386 0.8373475981380425 1.14423938238114 1.085179261008361 1.0354532425169718 1.0132424582527986 0.8095779891032743 1.0 9.40467991653506 -3.1920645215368104 15.648516832156371 0.9913507076160495 88.99708832899267 0.0 0.12155285257332343 0.0 0.0 0.02717801989823037 0.0 0.0006425922426546051 3.1920645215368104 88.00573762137662 GFQFVSS(ph)SLPDICYR ddPTM_A459_Selumetinib_30min_R2 2 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-5;P62633-6;P62633-8;P62633-4 P62633-2;P62633-8 CNBP Cellular nucleic acid-binding protein 1 GFQFVS(0.052)S(0.473)S(0.473)LPDICY(0.001)R;GFQFVS(0.003)S(0.498)S(0.498)LPDICYR 176.23 1.9238e-05 9498400.0 57059.0 44843.0 49326.0 61347.0 64201.0 46965.0 52112.0 54618.0 46540.0 52152.0 True False 53887.88920527462 48282.3139070288 46152.41886208811 52991.43277052222 56135.49641577782 53434.00244417782 54535.31125796905 54776.929337503345 55849.30043624905 50646.236252831 1.0640058016603835 0.9533248169913108 0.9112704571311221 1.0463054452059135 1.1083843651390777 1.0550438965973705 1.0767890230919315 1.081559724676312 1.1027334816637477 1.0 15.628167439471571 -5.950386987091789 8.252218425907197 1.0746333566690474 0.9742587591911227 0.46624497183436886 0.04516575530854196 0.21028417019586204 31.188575676224502 0.012465456461523576 0.0185059793265879 1.121019101835656e-06 5.950386987091789 -0.10037459747792465 GFS(ph)FVATGLMEDDGKPR ddPTM_A459_Selumetinib_30min_R1 2 GFSFVATGLMEDDGKPR 17 1 E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q5SVM6 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 GFS(0.999)FVAT(0.001)GLMEDDGKPR;GFS(1)FVATGLMEDDGKPR 161.14 1.2375e-05 13183100.0 2921.5 3499.4 4211.9 4914.0 3799.0 3839.6 4194.3 3780.5 2510.8 2887.9 True False 2989.5652657505766 3089.6886211730766 3639.9471143106216 4055.862147204313 3455.3811207679273 3800.977110077864 3877.9205741496958 3680.228859205338 4260.644218423559 3258.590095528131 0.9174413406133083 0.9481673148804929 1.1170312950087953 1.2446677944459184 1.0603914636301937 1.1664483714272833 1.1900608730970772 1.1293930047402512 1.307511559760333 1.0 11.670032168698716 -5.2866008745390145 3.468491913078113 1.1612887100128206 0.924113150185332 0.5394874554113281 0.0817048214943319 0.1590652512376155 4.033968183488806 0.020535607627603158 0.05408341660194757 5.1689118456667355e-06 5.2866008745390145 -0.2371755598274886 GFS(ph)LEELR ddPTM_A459_Selumetinib_30min_R1 2 GFSLEELR 8 0 P26373-2;P26373;J3QSB4 P26373-2 RPL13 60S ribosomal protein L13 1 GFS(1)LEELR;GFS(1)LEELR 114.86 0.010127 7290100.0 4887.1 4264.700000000001 5084.4 5699.9 5145.5 4379.9 4596.9 5145.200000000001 1988.19 3532.2 True False 5000.959921358771 3765.3869413947596 4393.966406610063 4704.519465374415 4680.090433511809 4335.842182631013 4250.152132014578 5008.732582034996 3373.81321834775 3985.59227654159 1.2547595374452711 0.9447496583022514 1.1024625957030485 1.1803815189687838 1.1742521835607467 1.0878790106431422 1.0663790566411258 1.2567097270625016 0.8465023475194262 1.0 11.96057841563741 -8.271080357097166 24.998920478264356 0.9232511665181299 1.125294130900104 0.4401712670529391 0.09446275123458268 700.2806117779194 1815797.1178988644 0.08350409738716295 0.022696572793212955 5.356975287357736e-09 8.271080357097166 0.20204296438197422 GFS(ph)LEELR ddPTM_A459_Selumetinib_30min_R2 1 GFSLEELR 8 0 P26373-2;P26373;J3QSB4 P26373-2 RPL13 60S ribosomal protein L13 1 GFS(1)LEELR 105.2 0.012563 0.0 9263.1 8847.8 8657.1 9077.6 11535.0 4914.5 7748.3 6988.5 7716.1 7159.2 True False 8748.293985127315 9526.397809838985 8100.111611137799 7841.2152202665575 10085.870175791608 5591.427765610813 8108.611302965174 7008.835377991544 9259.535605847474 6952.495294164512 1.258295563676265 1.3702127663192876 1.1650653856517563 1.1278274761074605 1.4506834955008245 0.8042332326789069 1.1662879239589032 1.0081035774126046 1.3318291079778717 1.0 12.763315147738139 -6.746478479476012 24.999991947301943 1.0691094790988975 1.265519916827088 0.3262073631397584 0.1521418450945498 310.7038062160997 519192.1275746043 0.04885286307869617 0.04866132455543399 1.7927573863803725e-07 6.746478479476012 0.19641043772819056 GFS(ph)TWLK ddPTM_A459_Selumetinib_30min_R2 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 1 GFS(0.944)T(0.056)WLK 113.71 0.018561 0.0 17530.0 15431.0 17392.0 17676.0 17430.0 15463.0 15500.0 12327.0 15639.0 12663.0 True False 16555.752778150054 16614.508081514654 16273.017654977826 15268.49830719924 15240.287573822949 17592.887890861744 16220.780712667323 12362.869529155289 18767.23699016972 12297.38628757477 1.3462822416888636 1.3510601109035572 1.323290760689531 1.241605163092784 1.2393111200565987 1.4306200910869593 1.3190429521642932 1.0053249723192548 1.5261159201880208 1.0 13.586064094247979 -13.021087449176349 0.34207315192533755 1.5937435584635947e-19 1.3132284490557686 0.3221881139434032 0.13096493087050357 153.13937224975837 3.4135548250095065 109.71080622013696 0.10119744806670747 9.526043290935314e-14 13.021087449176349 1.3132284490557686 GFS(ph)VVADTPELQR ddPTM_A459_Selumetinib_30min_R1 1 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 GFS(0.938)VVADT(0.062)PELQR 140.33 0.0013597 0.0 1066.3 1603.9 1444.1 1840.4 1616.5 1600.6 1268.0 1395.0 604.22 918.74 True False 1091.14271534138 1416.1146423671191 1247.9991518734935 1519.0086885866542 1470.287860416255 1584.4994172285215 1172.3537391273435 1358.0000684013883 1025.3172095172379 1036.6692282854378 1.0525466422361514 1.3660236107415396 1.203854728028898 1.4652780724464682 1.4182806051337948 1.5284522526526112 1.130885056814425 1.3099646746989917 0.9890495266392972 1.0 10.017739929213334 -8.185824041649973 1.6927610788424008 0.9762900901770435 1.3310111065809949 0.42204793922485717 0.1432445456785421 0.35120623863465106 1.825529402353784 0.13274360053877074 0.04059171613019157 6.518924607083036e-09 8.185824041649973 0.3547210164039514 GFS(ph)VVADTPELQR ddPTM_A459_Selumetinib_30min_R2 2 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 GFS(0.964)VVADT(0.036)PELQR;GFS(0.962)VVADT(0.038)PELQR 123.28 0.0024848 10456100.0 41459.0 42215.0 56819.0 48569.0 61371.0 37689.0 33409.0 39729.0 39464.0 52000.0 True False 39154.874753526725 45452.75475738068 53163.32739984968 41953.81841380175 53661.02631629884 42880.317643322 34962.5846986776 39844.60481250997 47357.902716289886 50498.62488777446 0.7753651676761991 0.9000790587544223 1.052767823242655 0.8307913038629816 1.0626235157007213 0.849138322847741 0.6923472624527232 0.7890235605634522 0.9378057882078106 1.0 15.623956482372312 -6.9773426376750685 24.984228962733404 0.8277170114404233 0.9280140457604418 0.06872361541321148 0.1135079902098642 448.8594116480987 494954.94692218077 0.03948104371431869 0.03481707105494949 1.0535553633788695e-07 6.9773426376750685 0.10029703432001846 GFSDS(ph)GGGPPAK ddPTM_A459_Selumetinib_30min_R2 1 GFSDSGGGPPAK 12 0 Q9H307;G3V5F0;G3V579 Q9H307 PNN Pinin 1 GFS(0.071)DS(0.929)GGGPPAK 117.95 0.0046415 9156100.0 50905.0 51133.0 61799.0 60236.0 68477.0 33275.0 43498.0 59006.0 39313.0 44939.0 True False 48075.90388886074 55054.73668149109 57822.91962166372 52031.752887104136 59874.30706785277 37858.32920962456 45520.74318965181 59177.69769103084 47176.698496997415 43641.49430445571 1.1016099392351075 1.2615227218713754 1.3249527896151831 1.1922541543631744 1.371958225127496 0.8674847141006191 1.0430610572609158 1.3559961370293618 1.0810055716213358 1.0 15.413412880585836 -6.735445816603451 24.999942537566795 1.0901059406128615 1.2519790084673965 0.3109539854803005 0.1329143762419295 327.8714435026658 315337.55876837496 0.04541407424428023 0.04540002062528443 1.838883362100556e-07 6.735445816603451 0.16187306785453504 GFSLEELR ddPTM_A459_Selumetinib_30min_R1 2 GFSLEELR 8 0 P26373-2;P26373;J3QSB4 P26373-2 RPL13 60S ribosomal protein L13 0 ; 153.78 0.011236 11630700.0 8688.7 10066.599999999999 10393.2 10316.0 10155.2 8202.1 9543.900000000001 9445.1 5546.0 8430.6 False True 8891.129804732864 8887.99779216462 8981.860525761098 8514.504255303153 9236.663953046176 8119.59432091094 8823.995939162027 9194.58526599136 9411.156936186491 9512.749630998118 0.9346540327057855 0.9343247890391555 0.9441918345556923 0.8950623726664585 0.970977300080274 0.8535486201016517 0.9275967813142346 0.9665539010960625 0.9893203649047403 1.0 13.21564669258735 -7.9206794131988 2.8054546685722412 0.9925934557572382 0.9221530772377615 0.5000394697545044 0.02949145357392757 0.23128826503655095 3.557105931550911 0.02045731320019759 0.007988359808772535 1.2003850745015409e-08 7.9206794131988 -0.07044037851947671 GFSLEELR ddPTM_A459_Selumetinib_30min_R2 1 GFSLEELR 8 0 P26373-2;P26373;J3QSB4 P26373-2 RPL13 60S ribosomal protein L13 0 152.47 0.013801 13978000.0 69284.0 68489.0 75479.0 85963.0 82728.0 71446.0 58661.0 65849.0 56555.0 64704.0 False True 65433.472645826994 73741.88607315505 70622.76331532151 74254.69110555387 72334.96904229642 81287.03797778611 61388.852734566346 66040.60968811126 67867.58027872937 62835.82739881842 1.0413401932391426 1.1735643362363317 1.1239250955840763 1.1817253655985147 1.151173972504365 1.2936415631461018 0.9769721395555414 1.0510024682089745 1.080077769135981 1.0 15.939299761472148 -7.286226019998588 24.99185447784117 1.0312632983081864 1.1602954911609755 0.5135970639808423 0.06377325299375658 676.7563576664725 682356.3173865852 0.0264552978717936 0.017844686338694574 5.1733752376650695e-08 7.286226019998588 0.1290321928527891 GFSQYGVS(ph)GSPTK ddPTM_A459_Selumetinib_30min_R1 1 GFSQYGVSGSPTK 13 0 Q9NXC5 Q9NXC5 MIOS WD repeat-containing protein mio 1 GFS(0.001)QYGVS(0.889)GS(0.108)PT(0.002)K 169.94 0.00024078 76288000.0 4206.3 4505.9 5090.8 5805.9 4168.7 3653.3 4115.8 3900.0 2368.8 2927.2 True False 4304.2986059649675 3978.347133263919 4399.497321762744 4792.008555240844 3791.641821043761 3616.5511189310023 3805.3418923504105 3796.5593310146296 4019.680589693215 3302.934633342545 1.3031740206160392 1.2044886063148823 1.3319964849896184 1.4508336032043623 1.1479615075538592 1.0949508604931366 1.1521093557033046 1.1494503380990437 1.2170027675132427 1.0 11.689532702942593 -6.394554214545118 8.372455901358606 1.132599669945298 1.3145783988171693 0.6127871827305422 0.07611407051653227 0.2242818391399701 14.181317931162837 0.024091164559947156 0.027307254939744452 4.031306190544336e-07 6.394554214545118 0.18197872887187128 GFSQYGVSGS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 GFSQYGVSGSPTK 13 0 Q9NXC5 Q9NXC5 MIOS WD repeat-containing protein mio 1 GFS(0.005)QYGVS(0.206)GS(0.64)PT(0.149)K;GFSQYGVS(0.005)GS(0.497)PT(0.497)K 127.05 0.0019662 72367700.0 7180.5 8156.200000000001 8389.7 9027.4 8332.4 6960.2 7605.7 7591.200000000001 3772.89 5947.0 True False 7347.791679179197 7201.268312285492 7250.42482132335 7450.934055285351 7578.735891204704 6890.186707355965 7031.995925615796 7389.856716307247 6402.318769017067 6710.3553786854745 1.0949929272775107 1.0731575163901654 1.0804829866914847 1.1103635552525613 1.1294090198676394 1.0267990767287378 1.0479319691401097 1.1012616022960744 0.9540953358972845 1.0 12.712173457867072 -8.260202805789877 24.999973534368273 0.9770476601116402 1.0820446708991436 0.6679562593676028 0.029888263064749933 65.65243128710425 1327381.8577614834 0.024122685430681606 0.007953733677905968 5.492843104948768e-09 8.260202805789877 0.10499701078750334 GFSQYGVSGS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 3 GFSQYGVSGSPTK 13 0 Q9NXC5 Q9NXC5 MIOS WD repeat-containing protein mio 1 GFSQYGVS(0.001)GS(0.936)PT(0.064)K;GFSQYGVS(0.079)GS(0.889)PT(0.032)K;GFSQYGVS(0.001)GS(0.849)PT(0.15)K 196.18 0.00010056 104081000.0 169114.0 158972.0 166526.0 174586.0 169515.0 144247.0 155699.0 155583.0 131134.0 154865.0 True False 159715.32089698064 171164.64122445392 155811.8984597999 150807.08562235173 148219.01021667232 164115.71490610726 162939.3120117155 156035.72077184796 157364.46419009668 150393.64506240777 1.0619818465780566 1.1381108633508215 1.036027143268878 1.0027490560506889 0.9855403807465863 1.0912410217732627 1.0834188635038517 1.0375153864187476 1.0463504899079763 1.0 17.198384081142187 GFSQYGVSGSPT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GFSQYGVSGSPTK 13 0 Q9NXC5 Q9NXC5 MIOS WD repeat-containing protein mio 1 GFSQYGVS(0.001)GS(0.227)PT(0.771)K 91.845 0.045006 3761900.0 1210.0 1666.9 1426.9 1255.8 1719.6 1185.5 1304.3 1152.8 682.86 902.37 True False 1238.1906457498537 1471.7385730792141 1233.134817400657 1036.4981042855466 1564.0624836200377 1173.574946347878 1205.915600902046 1122.2239991778633 1158.763545878888 1018.1979793281342 1.216060796513153 1.4454345843922731 1.2110953296276925 1.0179730517335026 1.5361084144481374 1.1525999561718543 1.1843625948833434 1.1021667907044674 1.1380532758899276 1.0 9.991802392268843 -7.9538589527689085 0.6482056422599574 1.0085864668183133 1.2816418209975413 0.2831709603084297 0.13720566101183818 0.940592421299935 0.8381484765563185 0.13228936817399495 0.06476434172560896 1.1120928466474813e-08 7.9538589527689085 0.273055354179228 GFSQYGVSGSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GFSQYGVSGSPTK 13 0 Q9NXC5 Q9NXC5 MIOS WD repeat-containing protein mio 1 GFSQYGVS(0.078)GS(0.45)PT(0.472)K 178.23 0.00024831 44913000.0 60416.0 55772.0 58701.0 56329.0 63886.0 44267.0 55670.0 50976.0 38056.0 56760.0 True False 57058.32058441034 60049.53306475504 54924.24156881632 48656.89302705505 55860.06953191358 50364.37743418331 58258.765308012255 51124.33172046887 45668.263373482914 55121.191319809186 1.0351430950278646 1.0894092022857773 0.996426968534657 0.882725715138326 1.0134046125349045 0.9137026292115643 1.0569213747576516 0.9274896005757419 0.8285064651182689 1.0 15.750319448517047 -5.496225165852816 6.0409588224364255 0.948335667395156 1.0588012796825998 0.3461017477588074 0.06365303335825825 0.19879726791612226 24.048956824881852 0.01680924343238129 0.033651367333405534 3.1898835879743132e-06 5.496225165852816 0.11046561228744389 GFSVVADT(ph)PELQR ddPTM_A459_Selumetinib_30min_R1 6 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 GFS(0.001)VVADT(0.999)PELQR;GFS(0.042)VVADT(0.958)PELQR;GFS(0.428)VVADT(0.572)PELQR;GFS(0.002)VVADT(0.998)PELQR;GFS(0.331)VVADT(0.669)PELQR;GFS(0.005)VVADT(0.995)PELQR 195.94 0.00029759 784407400.0 29560.399999999998 37047.9 34100.700000000004 38091.4 36367.9 27604.5 35323.3 31609.1 19158.37 28590.5 True False 30249.09980547437 32710.314644898546 29470.012241737015 31439.452054134807 33078.429866274244 27326.82379288062 32658.83504204801 30770.72398717297 32510.35461801788 32260.36917005332 0.9376551038837468 1.0139473132645642 0.9135051147862704 0.9745533874212278 1.0253580698940146 0.8470710192072937 1.0123515595836572 0.9538242983200838 1.0077489952655785 1.0 14.977475327551925 -8.185020382055269 1.828925240248774 1.0046794716650091 0.9592238630462595 0.09835146918469095 0.05089344977591485 0.8817224973663715 5.306840438054648 0.04490354054308671 0.01361022139846292 6.53099901024662e-09 8.185020382055269 -0.04545560861874964 GFSVVADT(ph)PELQR ddPTM_A459_Selumetinib_30min_R2 6 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 GFS(0.022)VVADT(0.978)PELQR;GFS(0.002)VVADT(0.998)PELQR;GFS(0.002)VVADT(0.998)PELQR;GFS(0.021)VVADT(0.979)PELQR;GFS(0.036)VVADT(0.964)PELQR;GFS(0.173)VVADT(0.827)PELQR 191.63 0.00023136 621239000.0 794360.0 726043.0 829500.0 866240.0 921770.0 744200.0 676252.0 732400.0 553310.0 707358.0 True False 750212.6512750306 781728.1635037998 776130.8730913132 748256.6176526517 805969.011871646 846706.7948250214 707699.0579679164 734531.1627446521 663987.4607731197 686934.7366031983 1.0921163413350345 1.137994807729978 1.129846594931533 1.0892688603180587 1.1732832377309328 1.2325869543471841 1.0302275023496335 1.0692881340908917 0.966594678348121 1.0 19.389813514307754 -7.396582546161046 8.385515611663308 1.020671532432032 1.140631053395643 0.6516182067423666 0.04512491522808832 0.20843493786232295 13.207771730038827 0.019666595981742797 0.013219732012942192 4.0125222518052314e-08 7.396582546161046 0.11995952096361107 GFT(ph)VMNENERY(ph) ddPTM_A459_Selumetinib_30min_R2 1 GFTVMNENERY 11 1 C9JPY0 C9JPY0 PCYT1A 2 GFT(1)VMNENERY(1) 58.676 0.034526999999999995 852900.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GFTECEMTKS(ph)SPLK ddPTM_A459_Selumetinib_30min_R1 1 GFTECEMTKSSPLK 14 1 Q9NQW6 Q9NQW6 ANLN Actin-binding protein anillin 1 GFTECEMTKS(0.5)S(0.5)PLK 148.41 0.0021836 20728000.0 2222.2 2361.3 3140.3 3557.2 2531.2 2591.8 2119.8 1960.0 1309.3 1677.1 True False 2273.972936351509 2084.8378982614113 2713.864508433163 2936.001796913958 2302.2534069196568 2565.728845166115 1959.9017793392295 1908.0144330227386 2221.7864725115364 1892.3721213373813 1.201652101461124 1.101706094036098 1.434107212758564 1.551492840022934 1.2165965567557628 1.355826803954847 1.035685189630739 1.0082659808337815 1.1740748278099504 1.0 10.885980096817196 -7.264583747334719 24.941339111659783 1.0551953179034677 1.3130930728078318 0.4959131584945925 0.12628620008290042 253.90661685279747 2013988.501262454 0.0554161541436508 0.03913546294567335 5.437712632798013e-08 7.264583747334719 0.2578977549043642 GGAAGGALPT(ph)SPGPALGAK ddPTM_A459_Selumetinib_30min_R1 1 GGAAGGALPTSPGPALGAK 19 0 Q9UPR0 Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 1 GGAAGGALPT(0.887)S(0.113)PGPALGAK 146.1 0.00011158 14813000.0 1386.9 1553.8 1670.7 1867.4 1564.6 1184.7 1628.1 1593.4 1013.1 1099.6 True False 1419.2120715623735 1371.8803736579764 1443.8281164981968 1541.293645439425 1423.0822062525651 1172.782993621535 1505.2911062091698 1551.1378559073619 1719.1567061035955 1240.7443710110222 1.1438392183926869 1.1056913943845643 1.1636789577547642 1.242233034822072 1.1469584223001268 0.9452253187865695 1.2132161478053545 1.250167151387852 1.3855849329404883 1.0 10.27699019411646 -7.500311088084316 24.619731105349 1.2370640154917212 1.1274950976823552 0.11470436157054775 0.11280389778048282 1122.168823475008 1224211.8332543748 0.04706638731123325 0.0314515789779676 3.1600133103040014e-08 7.500311088084316 -0.10956891780936595 GGAAGGALPTS(ph)PGPALGAK ddPTM_A459_Selumetinib_30min_R1 1 GGAAGGALPTSPGPALGAK 19 0 Q9UPR0 Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 1 GGAAGGALPT(0.243)S(0.757)PGPALGAK 100.68 0.0012499 11296000.0 5045.2 6208.1 6422.2 6722.5 6354.2 5134.2 6302.9 6073.9 3352.3 4559.3 True False 5162.743343749722 5481.252765932612 5550.10051461945 5548.541571953801 5779.463731925124 5082.554609480616 5827.467178506099 5912.800441192247 5688.60825769527 5144.530566342812 1.0035402214394573 1.065452463591673 1.0788351712651896 1.0785321421266618 1.1234190675697897 0.9879530394342173 1.1327500348877855 1.1493372164752418 1.1057584719025662 1.0 12.328823723198724 -3.4260312841133125 0.976100383188725 1.0891398686054035 3.454106835998323e-07 0.17166258020339198 0.050279206275339196 38.873289675615474 3.521908795823498 0.01613486857222164 79.4299662056568 0.00037494599228822225 3.4260312841133125 -1.0891395231947198 GGAAGGALPTS(ph)PGPALGAK ddPTM_A459_Selumetinib_30min_R2 2 GGAAGGALPTSPGPALGAK 19 0 Q9UPR0 Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 1 GGAAGGALPT(0.207)S(0.793)PGPALGAK;GGAAGGALPT(0.211)S(0.789)PGPALGAK 231.21 9.7904e-24 20591500.0 128532.0 109961.0 134226.0 137010.0 148953.0 100818.0 120807.0 121158.0 92664.0 119474.0 True False 121388.70599436302 118394.6551196575 125590.04529421896 118349.00164456709 130240.19248328448 114704.7643653173 126424.76487452906 121510.54972121326 111199.38924848688 116024.47518926853 1.0462336140400024 1.0204282753834701 1.0824444160539946 1.0200347939648648 1.1225234354288276 0.9886255824747459 1.089638756549381 1.0472837694201624 0.9584132060678527 1.0 16.82406964625173 -8.226657814470181 9.53096141151458 0.9792512623757952 1.052551101758942 0.37360186350245794 0.03777939462645868 0.4174698516346422 112.9562040971611 0.023885248494697496 0.008874275502384196 5.933926812369092e-09 8.226657814470181 0.07329983938314677 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKS(ph)VSGTDVQEECR ddPTM_A459_Selumetinib_30min_R2 1 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECR 41 2 P49321-4;P49321;P49321-3;E9PPR5 P49321-4 NASP Nuclear autoantigenic sperm protein 1 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKS(0.333)VS(0.333)GT(0.333)DVQEECR 47.668 0.0019338 23482000.0 51269.0 47610.0 48708.0 50685.0 44787.0 38848.0 47999.0 47484.0 34123.0 42241.0 True False 48419.6742260682 51261.533909721504 45574.18030926062 43781.61556349812 39160.45665913991 44198.95937296752 50231.04860821413 47622.17057860065 40948.553476281195 41021.39257470154 1.180351791760704 1.2496292956503676 1.1109856942635061 1.0672874033656978 0.9546349892395098 1.0774612122803853 1.2245086150291327 1.1609106271045977 0.998224363098164 1.0 15.324088848122804 -5.4010713361472416 4.428873645055042 1.078426868718519 1.2138582644302705 0.355688111866595 0.076650977709753 0.2733903130820623 8.517305033721053 0.022118031280781103 0.04828556947464713 3.9712631311687795e-06 5.4010713361472416 0.13543139571175145 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVS(ph)GTDVQEECR ddPTM_A459_Selumetinib_30min_R1 1 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECR 41 2 P49321-4;P49321;P49321-3;E9PPR5 P49321-4 NASP Nuclear autoantigenic sperm protein 1 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKS(0.364)VS(0.478)GT(0.158)DVQEECR 83.585 3.5772000000000003e-10 24067000.0 1164.9 1549.9 1409.6 1460.6 1556.9 1146.5 1476.6 1479.6 884.85 1148.3 True False 1192.0399034991776 1368.436987471039 1218.1840623785583 1205.5336288576766 1416.07866989302 1134.9672509387103 1365.2188731825192 1440.356201581858 1501.5258231129856 1295.6954903891933 0.920000040396158 1.0561408892918165 0.9401777434701478 0.9304143124674807 1.0929100860478158 0.8759521502986752 1.0536571928427743 1.1116471518699291 1.1588570264005211 1.0 10.339510985813318 -7.507304661094284 16.22563230052098 1.0976849274897247 0.9748341972397905 0.3799175839047668 0.07070406526832836 7.055605357789044 7353.594806173554 0.02912327974745364 0.01875341718703811 3.109534208388921e-08 7.507304661094284 -0.1228507302499342 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGT(ph)DVQEECR ddPTM_A459_Selumetinib_30min_R1 1 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKSVSGTDVQEECR 41 2 P49321-4;P49321;P49321-3;E9PPR5 P49321-4 NASP Nuclear autoantigenic sperm protein 1 GGAAPEGPNEAEVTSGKPEQEVPDAEEEKS(0.098)VS(0.401)GT(0.501)DVQEECR 61.84 2.8946e-05 31840000.0 1909.0 2373.7 1644.8 1945.4 2362.1 1951.7 2191.9 2093.7 898.42 1430.8 True False 1953.475985732621 2095.7861004968076 1421.44519423968 1605.6724096807638 2148.448472062626 1932.0676700018166 2026.5632182911847 2038.1682747039322 1524.5531219994 1614.4571171722182 1.2099893920714395 1.2981367409545415 0.8804477858968432 0.994558723549845 1.330755985532594 1.196729011536649 1.2552598621143842 1.2624480718780935 0.944313172386834 1.0 10.656833405598732 -8.2722505507469 24.4960612577906 0.9721565342940788 1.1746954948229082 0.27867523589226506 0.132701312300044 896.7824185985849 2031909.5477905709 0.13231179046706015 0.03561714797085135 5.342560504548577e-09 8.2722505507469 0.20253896052882947 GGAEDERGEDGDGEQDAEKDGS(ph)GPEGGIVEPR ddPTM_A459_Selumetinib_30min_R2 1 GGAEDERGEDGDGEQDAEKDGSGPEGGIVEPR 32 2 K7EKB8;K7ESN2;Q9C0B9 K7EKB8 ZCCHC2 Zinc finger CCHC domain-containing protein 2 1 GGAEDERGEDGDGEQDAEKDGS(1)GPEGGIVEPR 60.343 0.00037568 3523900.0 14769.0 14381.0 15832.0 17002.0 13675.0 11516.0 11277.0 9947.0 7949.5 14322.0 True False 13948.198104991343 15483.976457796787 14813.38635657825 14686.298269914076 11957.024243948872 13102.22446816038 11801.402844951572 9975.9441231855 9539.622127588345 13908.486646975109 1.0028551961851917 1.1132754303764834 1.0650609755447364 1.0559235265979228 0.8596926860155091 0.9420309197341697 0.8485037333316349 0.7172559011195601 0.6858849830123734 1.0 13.763677831372066 -6.598607505077044 1.0421244619669578 0.7899582743677704 1.0745908024713415 0.5669714105527839 0.09176626027058314 0.34522928469001074 0.8052953506963776 0.04693917473666024 0.050297833742641684 2.519953314221866e-07 6.598607505077044 0.2846325281035711 GGAEQFMEETER ddPTM_A459_Selumetinib_30min_R1 4 GGAEQFMEETER 12 0 Q99832-2;Q99832-4;Q99832-3;Q99832 Q99832-2 CCT7 T-complex protein 1 subunit eta 0 ;;; 224.75 1.1828e-06 82117600.0 5065.889999999999 5338.8 5698.0 6265.3 5926.9 4600.2 5820.2 5185.219999999999 3113.0600000000004 4596.03 False True 5183.915380493993 4713.730814059217 4924.2428968736 5171.182969246885 5390.812941479184 4553.926164647409 5381.177628130099 5047.691121631716 5282.635451093531 5185.97521962331 0.9996028058287817 0.9089381677380256 0.9495307417283183 0.9971476434518135 1.039498399660836 0.8781233946926166 1.0376404437429934 0.9733349867410976 1.0186387761947775 1.0 12.340399597175706 -6.608271735358637 0.3984409493321413 1.0062393647186678 0.9475487601906445 0.08683174483972567 0.04857088453276801 4.072895226890696 1.2784643404303293 0.05003478602673304 0.0964556953520498 2.464496834362461e-07 6.608271735358637 -0.05869060452802333 GGAEQFMEETER ddPTM_A459_Selumetinib_30min_R2 1 GGAEQFMEETER 12 0 Q99832-2;Q99832-4;Q99832-3;Q99832 Q99832-2 CCT7 T-complex protein 1 subunit eta 0 126.66 0.037447 6645700.0 60833.0 58246.0 57252.0 55275.0 62083.0 43360.0 50586.0 51447.0 39475.0 51876.0 False True 57452.1453937936 62713.28090959122 53568.468651264455 47746.449645306464 54283.57851093803 49332.44641710958 52938.3492342574 51596.70225249064 47371.10302365557 50378.20508996516 1.140416680014618 1.244849450225512 1.0633262649116249 0.9477600394861445 1.077521090995574 0.9792418433529327 1.050818486679316 1.0241869903929586 0.9403094639648332 1.0 15.620512101186193 -5.433170395975554 4.747592643373992 1.007648251511797 1.1900715212877655 0.7201385495928779 0.046612439325994154 0.10501561184003873 3.9764185009620996 0.01168861800387592 0.025008130140302082 3.688328581507196e-06 5.433170395975554 0.18242326977596846 GGAES(ph)HTFK ddPTM_A459_Selumetinib_30min_R2 2 GGAESHTFK 9 0 P50238;K4DIB9;H3BRQ4 P50238 CRIP1 Cysteine-rich protein 1 1 GGAES(0.998)HT(0.002)FK;GGAES(0.994)HT(0.006)FK 81.525 0.028876 29445000.0 306510.0 309140.0 301450.0 274880.0 306780.0 159581.0 198700.0 252620.0 175229.0 326120.0 True False 289475.40125674685 332850.0439582293 282055.03519394295 237440.86980555078 268239.5537520026 181561.83421791403 207939.94371658054 253355.08237650737 210279.69630733755 316704.0682384813 0.9140248903868484 1.0509812703371715 0.8905949227704669 0.7497247229131122 0.8469722389231058 0.5732854498136607 0.6565749056308292 0.799974196055254 0.6639627254456196 1.0 18.272775874135675 -5.645416361273393 2.5948403288405575 0.7364975020576547 0.9843181362458194 0.38280981984187357 0.11580200846022154 0.2514452579917463 3.408021684390344 0.0323411516381837 0.06471729659743541 2.262474217057838e-06 5.645416361273393 0.2478206341881647 GGAESHTFK ddPTM_A459_Selumetinib_30min_R1 1 GGAESHTFK 9 0 P50238;K4DIB9;H3BRQ4 P50238 CRIP1 Cysteine-rich protein 1 0 138.4 0.0034707 3796400.0 6715.8 10269.0 9626.8 6830.6 5962.2 7021.5 5186.5 8855.1 13081.0 7378.0 False True 6872.265073327994 9066.700706071422 8319.533436227237 5637.76393624212 5422.920062711908 6950.870085011908 4795.278129324895 8620.233982581452 22197.501601560674 8325.038167805864 0.8254935214476308 1.0890881847405427 0.9993387740130832 0.6772057764304522 0.6513988228526243 0.8349355216042055 0.5760067440734308 1.035458794161107 2.666354334254184 1.0 13.023241171185688 -8.02440233525418 23.030356009828836 1.8390881200645897 0.815136880090286 0.5053492601656657 0.4001169237046485 204.5215501670524 193019.82854973822 0.24457346742102493 0.09377171647225296 9.453609626235753e-09 8.02440233525418 -1.0239512399743038 GGAESHTFK ddPTM_A459_Selumetinib_30min_R2 1 GGAESHTFK 9 0 P50238;K4DIB9;H3BRQ4 P50238 CRIP1 Cysteine-rich protein 1 0 102.62 0.022435 8295200.0 128310.0 113910.0 91939.0 88759.0 84003.0 106250.0 180210.0 393880.0 167780.0 274930.0 False True 121179.04386562652 122646.53072162099 86023.74483561431 76669.87108218478 73449.79214365168 120884.97305853073 188590.1220793406 395026.12558965554 201340.6881648877 266992.05654607416 0.4538675997827484 0.4593639687570861 0.3221958958197298 0.28716161849164995 0.275101038936627 0.45276617822399484 0.7063510597244905 1.4795426152368951 0.7541074096717286 1.0 18.02643729443181 -7.465718665863846 3.4164771140638472 1.0921570239574514 0.369974310741301 0.7482108510496084 0.1815079000577166 0.11002932105915901 2.5509840603846015 0.08230104110124649 0.04989193234654466 3.422010471256897e-08 7.465718665863846 -0.7221827132161505 down GGAGAWLGGPAAS(ph)LSPPK ddPTM_A459_Selumetinib_30min_R2 1 GGAGAWLGGPAASLSPPK 18 0 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GGAGAWLGGPAAS(0.834)LS(0.166)PPK 75.998 0.014968 3932600.0 18864.0 16281.0 19872.0 18564.0 19862.0 17054.0 19962.0 21075.0 17337.0 14704.0 True False 17815.61439857516 17529.700348333892 18593.457154997683 16035.551175313785 17366.757991467093 19403.033699201726 20890.27255395258 21136.32476084592 20804.884436253767 14279.457314419918 1.247639458999909 1.227616705757561 1.3021123104042147 1.1229804342158367 1.2162057429121977 1.3588075003108018 1.4629598376162951 1.4801910391581679 1.4569800503023482 1.0 13.801653530858168 -6.82238402106964 4.670831336306434 1.3920806711333062 1.2220486009690588 0.15312743380587146 0.13708997650511875 0.2848536279948723 12.387384049493926 0.046631791031662866 0.04173152459535414 1.5052754509824206e-07 6.82238402106964 -0.17003207016424748 GGAGAWLGGPAASLS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 GGAGAWLGGPAASLSPPK 18 0 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GGAGAWLGGPAAS(0.01)LS(0.99)PPK 133.86 0.00041444 4471900.0 35428.0 25963.0 31271.0 31238.0 27505.0 25667.0 32959.0 31626.0 23952.0 21848.0 True False 33459.053589520845 27954.278615797106 29259.05790529046 26983.33051144431 24049.576002180173 29202.39626817229 34491.658807019514 31718.026424033837 28743.069274796668 21217.191472078764 1.576978443803556 1.3175296387641202 1.3790259631579689 1.271767309398778 1.1334947904782189 1.3763554100269038 1.625646771035157 1.494921062751113 1.3547065978370298 1.0 14.372946078334419 -11.66611908227704 1.9283478857127268 0.26719440982131587 1.387941815706583 0.4236188841277613 0.1371856439672508 4446608.326385708 949632.9770758429 14238818.062389903 0.03776464893980437 2.1571528430515766e-12 11.66611908227704 1.1207474058852671 GGAGAWLGGPAASLS(ph)PPKGSSASQGGSK ddPTM_A459_Selumetinib_30min_R1 2 GGAGAWLGGPAASLSPPKGSSASQGGSK 28 1 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GGAGAWLGGPAAS(0.02)LS(0.976)PPKGS(0.003)S(0.001)ASQGGSK;GGAGAWLGGPAAS(0.185)LS(0.685)PPKGS(0.044)S(0.06)AS(0.024)QGGS(0.002)K 85.913 1.7022e-05 44096000.0 4364.8 5082.6 6792.700000000001 6280.1 5253.9 4874.9 5069.4 4729.3 2986.9 4531.299999999999 True False 4466.491347577654 4487.526829163364 5870.288649630276 5183.398427077292 4778.685672651383 4825.8629320550535 4687.011076602642 4603.86360106859 5068.551145455362 5112.936493599715 0.8735667562405147 0.8776809246077616 1.148124694484002 1.0137811086771331 0.9346264477630926 0.9438534857798421 0.9166965172498741 0.900434340780807 0.9913190104747216 1.0 12.319936391473615 -6.285348051850165 23.59259372701157 0.9410886824477174 0.983233297081214 0.030240122066439556 0.07718884900156106 1295.4582815448634 1278326.7651586684 0.025626981644950832 0.029077886865684154 5.183844292806191e-07 6.285348051850165 0.04214461463349661 GGAGAWLGGPAASLS(ph)PPKGSSASQGGSK ddPTM_A459_Selumetinib_30min_R2 1 GGAGAWLGGPAASLSPPKGSSASQGGSK 28 1 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GGAGAWLGGPAAS(0.04)LS(0.952)PPKGS(0.001)S(0.006)AS(0.002)QGGSK 102.21 1.9312e-07 8975000.0 63280.0 62677.0 72779.0 75761.0 58348.0 38458.0 48186.0 44020.0 33549.0 47115.0 True False 59763.15092991071 67484.12436168068 68096.47837578368 65442.221104985394 51017.80260226172 43755.240413035026 50426.74447874763 44148.090912096704 40259.73743738116 45754.6675305287 1.3061651227174844 1.4749123532949622 1.4882957750779842 1.430285141102176 1.1150294681569115 0.9563011332961909 1.1021114828361849 0.9648871534830835 0.8799044908482576 1.0 15.481631302829616 -6.373856582361366 2.97926190356419 0.9875844656372411 1.4367153914710327 0.9002595680339466 0.06983525807543915 0.07945803753600343 1.3544314450935424 0.023854856584889277 0.027697891317959213 4.2280821572777663e-07 6.373856582361366 0.44913092583379155 GGAGGGPGGAGGGS(ph)GQR ddPTM_A459_Selumetinib_30min_R2 2 GGAGGGPGGAGGGSGQR 17 0 Q6VY07-2;Q6VY07 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 GGAGGGPGGAGGGS(1)GQR;GGAGGGPGGAGGGS(1)GQR 122.63 0.0011203 561840.0 546.92 1461.89 1177.78 780.31 1671.1399999999999 1505.6 2339.4 2293.0 1882.29 2214.6 True False 516.5243758942286 1574.0122622827728 1102.0029170699056 674.0304318901696 1461.1964530188461 1712.9827335239893 2448.1867354331575 2299.6722503734145 2258.8005955768626 2150.6587437781777 0.2401703093940522 0.7318744858227116 0.5124025000516622 0.3134065010732777 0.6794180886419404 0.7964921159526688 1.138342725230455 1.0692873785886907 1.050283129348874 1.0 11.070562907648535 -6.849719074441014 1.9091068789655088 1.0695145243419477 0.4776324982353461 0.8027749660916894 0.13468680916892892 0.14397645451743518 1.0779405462123957 0.05606675005265763 0.048230312424966684 1.4134515471840396e-07 6.849719074441014 -0.5918820261066016 down GGAGVGS(ph)MTK ddPTM_A459_Selumetinib_30min_R2 1 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 1 GGAGVGS(0.982)MT(0.018)K 89.561 0.03067 5703100.0 30005.0 33899.0 38761.0 29035.0 29389.0 22757.0 20974.0 26877.0 16860.0 37888.0 True False 28337.442219531786 36498.94429753516 36267.15945978587 25080.382911831293 25696.89107900647 25891.570182522206 21949.332559192546 26955.207620273137 20232.471107760182 36794.074995153795 0.7701631913090397 0.9919788526370753 0.9856793373542527 0.6816418924822725 0.698397529558524 0.7036885744765271 0.5965453014400696 0.73259642004381 0.5498839449130066 1.0 15.167185845198082 -5.769289804699883 24.97910512490335 0.6924786692689279 0.9235443054985892 0.35733310228901427 0.1257232055835301 154.16688135518237 490541.7109715905 0.032992589178408575 0.049962569414393664 1.7010230369453987e-06 5.769289804699883 0.23106563622966136 GGAPDPSPGATATPGAPAQPS(ph)SPDAR ddPTM_A459_Selumetinib_30min_R1 2 GGAPDPSPGATATPGAPAQPSSPDAR 26 0 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 GGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR;GGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR 168.78 2.6289e-17 29542000.0 9392.599999999999 10877.5 8702.5 9722.9 9489.2 8198.1 9092.900000000001 9456.2 4890.5 8284.0 True False 9611.429305181879 9603.957243187446 7520.7482994107595 8024.978036437286 8630.903535454332 8115.6345572792325 8407.015232264208 9205.390857933478 8298.821312012267 9347.33209299319 1.0282537530025981 1.0274543738941964 0.8045876860466263 0.8585313923373764 0.923354755088257 0.8682300443099432 0.8994026475817791 0.9848147863318013 0.887827802569795 1.0 13.190338935711381 -10.484368755341347 15.019844423580375 0.9999999958787295 0.9180513935670315 0.10427639332188965 0.06982771647316076 0.0 0.0 0.07152202249614162 0.017346638429964378 3.2781682873706385e-11 10.484368755341347 -0.08194860231169798 GGAPDPSPGATATPGAPAQPS(ph)SPDAR ddPTM_A459_Selumetinib_30min_R2 2 GGAPDPSPGATATPGAPAQPSSPDAR 26 0 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 GGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR;GGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR 151.53 2.7379e-11 17705300.0 65520.0 57283.0 63400.0 71210.0 63233.0 58960.0 68262.0 71116.0 65928.0 53784.0 True False 61878.66069734119 61676.42190612427 59320.91302470074 61511.07515589827 55289.10522980763 67081.20481440914 71436.3182585869 71322.93578611234 79115.4421822311 52231.11617238579 1.1847087566176882 1.1808367583523354 1.1357389497271222 1.1776710831314519 1.058547266103392 1.284314977934063 1.3676965665986431 1.3655257825759477 1.5147185811828172 1.0 15.672621913800683 -6.938130693923498 6.1019228842499285 1.3404203611375862 1.1509291616552666 0.27489476539806423 0.12619873166384618 0.22507980365019228 16.261977881188994 0.042475218078672015 0.0372627200646224 1.1531061968806433e-07 6.938130693923498 -0.18949119948231963 GGAPDPSPGATATPGAPAQPS(ph)SPDARR ddPTM_A459_Selumetinib_30min_R1 1 GGAPDPSPGATATPGAPAQPSSPDARR 27 1 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 GGAPDPSPGAT(0.007)AT(0.006)PGAPAQPS(0.493)S(0.493)PDARR 108.31 8.3498e-10 6076800.0 714.48 500.24 1059.0 1037.5 1353.1 589.19 649.61 570.4 506.37 432.2 True False 731.1259938639301 441.6716682447332 915.1936166706114 856.3201012870317 1230.7123439092077 583.2632835417173 600.6093946959883 555.2711390796783 859.2729061984774 487.6770799845069 1.499201057156833 0.9056641912692815 1.8766385672660406 1.755916233164446 2.523621458585477 1.1960030673581115 1.2315719137652914 1.1386041334920205 1.7619710695154582 1.0 8.929782359463013 -8.424862529232785 0.592635288160253 1.059454155174564 1.614911796875181 0.11205444200832682 0.44407258318686565 2.0478055744205634 1.7230514211055712 0.4941533875160226 0.22291457938461434 3.759563899918447e-09 8.424862529232785 0.555457641700617 GGAPDPSPGATATPGAPAQPSS(ph)PDAR ddPTM_A459_Selumetinib_30min_R2 1 GGAPDPSPGATATPGAPAQPSSPDAR 26 0 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 GGAPDPSPGATATPGAPAQPS(0.386)S(0.614)PDAR 136.48 2.6347e-09 12821000.0 39475.0 32066.0 39425.0 41198.0 36350.0 29919.0 39559.0 43546.0 39623.0 30563.0 True False 37281.13753094541 34525.35909155913 36888.43842269438 35586.76132948595 31783.38802687691 34040.070672359354 41398.57188467141 43672.711650571604 47548.70715912112 29680.56677778942 1.2560790300960039 1.1632311252693182 1.2428481807260756 1.1989919732973648 1.0708484196016457 1.146880749522352 1.394803953529985 1.4714244501305411 1.6020147969243903 1.0 14.857231021363246 -7.269013505624907 21.567508512106652 1.4063463211327896 1.177843550445213 0.2521576813970554 0.15204792105314666 101.80043520484286 289872.71996649366 0.059828994152549796 0.041409012204930526 5.382530437432904e-08 7.269013505624907 -0.22850277068757663 GGAS(ph)SSCCEEEQTQGR ddPTM_A459_Selumetinib_30min_R2 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 GGAS(0.497)S(0.497)S(0.006)CCEEEQTQGR 356.36 6.385699999999996e-175 27773000.0 20060.0 17277.0 20076.0 18691.0 21271.0 17169.0 18329.0 16877.0 16244.0 18334.0 True False 18945.145506542507 18602.090345689114 18784.332017096083 16145.253556226573 18598.74681484728 19533.873905335662 19181.334818224484 16926.109275862247 19493.25389528211 17804.649782547232 1.0640560605192713 1.0447883318616893 1.0550239542206088 0.9067998389978297 1.0446005421054927 1.0971220520430274 1.0773216576844284 0.9506566814054291 1.0948406249692206 1.0 14.119966437718748 GGASS(ph)SCCEEEQTQGR ddPTM_A459_Selumetinib_30min_R1 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 GGAS(0.051)S(0.937)S(0.011)CCEEEQTQGR 360.25 1.204099999999999e-196 13221000.0 1482.3 1621.7 1665.0 1982.4 1724.3 1506.9 1451.4 1289.7 709.84 1282.2 True False 1516.8347059462888 1431.8306100921236 1438.9021451903382 1636.2110542567823 1568.3373694498907 1491.7419541557285 1341.9197294711562 1255.492966463992 1204.5466353376528 1446.7828596856434 1.048419046294111 0.9896651736689992 0.9945529389966525 1.1309306322666124 1.0840171066103579 1.031075219179645 0.92751978673754 0.8677825826169832 0.8325690529671995 1.0 10.498632695984474 -7.318292350315525 3.0903002808745126 0.8890139792768165 1.0485678357744226 0.6059328299286189 0.05527836943816007 0.1769396155112235 3.3614765421344703 0.026245025834510816 0.017193341699257292 4.8051577484388715e-08 7.318292350315525 0.15955385649760612 GGASS(ph)SCCEEEQTQGR ddPTM_A459_Selumetinib_30min_R2 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 GGASS(0.984)S(0.016)CCEEEQTQGR 317.17 1.515799999999999e-104 15371000.0 6181.7 5307.7 7654.8 7503.5 7755.9 5073.8 5721.2 6431.0 6394.3 5303.4 True False 5838.145861305775 5714.783523054586 7162.298501916073 6481.510355740523 6781.534503374269 5772.669894629393 5987.247136342732 6449.713145290637 7673.338671669688 5150.277062111977 1.1335595718246123 1.1096070083482308 1.3906627576612403 1.2584779959551624 1.3167319780255398 1.120846475832543 1.162509718241748 1.2523041124793002 1.489888520390217 1.0 12.330434329653729 -11.669850013668196 2.6369742706929973 0.4030186058433532 1.2445560132107991 0.2839938538336927 0.11813785787292112 94703700.03550352 85387678.46054302 326047337.18301845 0.03060169121596401 2.1387005756744803e-12 11.669850013668196 0.841537407367446 GGASSS(ph)CCEEEQTQGR ddPTM_A459_Selumetinib_30min_R1 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 GGAS(0.072)S(0.287)S(0.64)CCEEEQT(0.001)QGR 78.508 0.026116000000000004 737180.0 0.0 141.54 123.26 59.972 112.61 62.527 193.59 0.0 120.42 0.0 True False 0.0 124.96843099983919 106.52196901871534 49.49901601386591 102.4244453829103 61.89803514997361 178.98735043979684 0.0 204.3439448711824 0.0 0.0 GGCGS(ph)PGLQCK ddPTM_A459_Selumetinib_30min_R1 2 GGCGSPGLQCK 11 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 GGCGS(1)PGLQCK;GGCGS(1)PGLQCK 110.98 0.0085117 37965000.0 7728.6 8292.1 8963.2 9260.1 8508.2 6927.8 8176.9 7437.1 4533.5 5962.6 True False 7908.6613427622515 7321.257077107294 7746.0466713333535 7642.997368605343 7738.634812244719 6858.112621939116 7560.109849740041 7239.843948894595 7693.018386260634 6727.957790642344 1.175492116457999 1.0881841570543365 1.15132212662021 1.1360055467701793 1.150220475967921 1.0193453697759223 1.1236856836787985 1.0760834378248054 1.1434403463351919 1.0 12.715952939211448 -6.717908403424111 24.99994365736907 1.0804643557779132 1.1377325516687782 0.3540907573154858 0.045041923988718785 175.0167909836407 100512.01861338814 0.014023460362604578 0.014023361976351206 1.914659701230599e-07 6.717908403424111 0.05726819589086496 GGCGS(ph)PGLQCK ddPTM_A459_Selumetinib_30min_R2 4 GGCGSPGLQCK 11 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 GGCGS(1)PGLQCK;GGCGS(1)PGLQCK;GGCGS(1)PGLQCK;GGCGS(1)PGLQCK 112.64 0.0075536 61299000.0 240381.0 208556.0 251035.0 256827.0 263923.0 199581.0 216489.0 228695.0 178740.0 226328.0 True False 227021.58634138573 224551.5745867655 234883.68140624173 221846.71954871347 230766.63323844367 227071.4711340668 226556.16746481514 229360.46458750454 214492.9944128738 219793.3225692352 1.0328866395378031 1.0216487560309364 1.068657039534279 1.0093423992843615 1.049925587096723 1.0331136018135354 1.030769109891633 1.0435279011502074 0.975884944572455 1.0 17.74578803159482 -8.25808699384809 24.996782006351967 0.9879424695666144 1.0361023206837148 0.5921839433060077 0.016029707570541306 171.63554660651175 1279803.9777038577 0.011018814125354076 0.003772433611432161 5.51966863316721e-09 8.25808699384809 0.048159851117100416 GGCPGGEATLS(ph)QPPPR ddPTM_A459_Selumetinib_30min_R1 4 GGCPGGEATLSQPPPR 16 0 P20290 P20290 BTF3 Transcription factor BTF3 1 GGCPGGEAT(0.009)LS(0.991)QPPPR;GGCPGGEATLS(1)QPPPR;GGCPGGEATLS(1)QPPPR;GGCPGGEATLS(1)QPPPR 232.26 1.9017e-15 126438000.0 7432.8 7942.6 7468.400000000001 7802.500000000001 7576.6 6753.7699999999995 7792.6 7499.0 3813.04 6442.0 True False 7605.969778288854 7012.676699585436 6454.232300984699 6439.9398460646435 6891.297867757373 6685.8332057325215 7204.797908141751 7300.102159815057 6470.450386577088 7268.893450393783 1.0463724403439716 0.9647516155578719 0.8879250115621173 0.8859587625012949 0.948053223614668 0.9197869319944875 0.9911822146397593 1.004293460845761 0.8901561744898819 1.0 12.827520042873683 -7.260622336513552 24.985705225706848 0.9717657502293511 0.9384196627013823 0.06811172573590452 0.05194358616874251 209.94347229671803 6420322.678500856 0.021577453447629322 0.01573129444018972 5.487539552041652e-08 7.260622336513552 -0.03334608752796875 GGCPGGEATLS(ph)QPPPR ddPTM_A459_Selumetinib_30min_R2 4 GGCPGGEATLSQPPPR 16 0 P20290 P20290 BTF3 Transcription factor BTF3 1 GGCPGGEATLS(1)QPPPR;GGCPGGEATLS(1)QPPPR;GGCPGGEATLS(1)QPPPR;GGCPGGEAT(0.002)LS(0.998)QPPPR 191.51 8.5417e-07 104168000.0 78308.0 63760.0 71658.0 73928.0 92223.0 78613.0 60423.6 63277.0 43661.5 76532.0 True False 73955.95485176123 68650.18697928678 67047.60229533123 63858.878867086656 80637.12225591934 89441.22717223791 63233.41712709194 63461.125593928744 52395.02000423913 74322.32230598386 0.9950705596534739 0.9236819417005703 0.9021193124092286 0.859215332429746 1.0849650516023643 1.2034234722108084 0.8507998023361129 0.8538635987807305 0.7049701674892455 1.0 16.181507961019506 -7.481419016971744 24.997052970304708 0.8381161967507125 0.9887346818570398 0.27156800776136414 0.11317387452533473 675.6781520466479 407383.2662271724 0.050138436922031536 0.033799409706316445 3.300509468766454e-08 7.481419016971744 0.15061848510632736 GGDAKS(ph)PVLQEK ddPTM_A459_Selumetinib_30min_R2 1 GGDAKSPVLQEK 12 1 A6NFI3 A6NFI3 ZNF316 Zinc finger protein 316 1 GGDAKS(1)PVLQEK 119.62 0.020095 6931300.0 33558.0 37764.0 27075.0 35950.0 32045.0 24480.0 30923.0 24344.0 20457.0 31971.0 True False 31692.980703317702 40660.377369601425 25333.023977031095 31053.54798279092 28019.220614065212 27851.897792685486 32360.980772762065 24414.837009633844 24548.9716163375 31047.914159366097 1.0207764856808266 1.3096009336052474 0.8159332007618614 1.0001814557781854 0.9024509817389059 0.8970618009868311 1.0422916208366242 0.7863599752406788 0.7906802205884067 1.0 14.922208729057413 -5.26897148107296 24.998276097149848 0.904757983878645 1.165188714239551 0.4888892849202191 0.10667156035962862 408.1851900174248 1354728.6900955322 0.027006390835616307 0.057999699258116814 5.383051303766256e-06 5.26897148107296 0.2604307303609059 GGDDYS(ph)EDEGDSSVSR ddPTM_A459_Selumetinib_30min_R2 2 GGDDYSEDEGDSSVSR 16 0 A6NDA1;Q99871-3;Q99871;Q99871-2 A6NDA1 HAUS7 HAUS augmin-like complex subunit 7 1 GGDDYS(1)EDEGDSSVSR;GGDDYS(1)EDEGDSSVSR 233.14 1.4698e-15 16489600.0 37324.0 32774.0 37787.0 37819.0 43795.0 26742.0 29860.0 34233.0 28700.0 31711.0 True False 35249.681499810176 35287.6604149803 35355.82555937486 32667.986958586087 38293.080567732424 30425.467760293905 31248.5491664675 34332.61236242175 34440.80194500103 30795.42103492721 1.144640349610128 1.1458736146181645 1.148087097730386 1.0608066349063736 1.2434666999454758 0.9879867440612773 1.0147141398400226 1.1148609503822913 1.118374121462387 1.0 14.910428232375317 -6.775761136824594 24.99999971070255 1.0523364526578014 1.1435217192171867 0.4321657842303681 0.05781363311750746 265.8633218497441 464087.09952883195 0.020635488561885268 0.01828414462675561 1.6758643526603734e-07 6.775761136824594 0.0911852665593853 GGDHVPVS(ph)HEQPR ddPTM_A459_Selumetinib_30min_R2 2 GGDHVPVSHEQPR 13 0 Q9HBR0 Q9HBR0 SLC38A10 Putative sodium-coupled neutral amino acid transporter 10 1 GGDHVPVS(1)HEQPR;GGDHVPVS(1)HEQPR 84.859 0.018904 9671600.0 76214.0 30120.0 57085.0 51753.0 44221.0 44094.0 56020.0 47988.0 45394.0 46916.0 True False 71978.33098881503 32430.107148935338 53412.21324944857 44704.152121095365 38665.5626392441 50167.54825452096 58625.04100152412 48127.63713515892 54474.068414333684 45561.413177592796 1.5798090087384324 0.7117888776304361 1.1723124794495359 0.981184493704005 0.8486471323558485 1.1010972828909853 1.2867256942406704 1.0563245030957074 1.1956184985307732 1.0 15.47552487533749 -6.99365340572338 24.910569519919342 1.1471538471958604 1.0348128235320175 0.01808851410659751 0.22572958969459606 521.470036710959 2046771.3963135465 0.07526851094170901 0.06620942592991212 1.0147208736791467e-07 6.99365340572338 -0.11234102366384291 GGDISVCEWYQR ddPTM_A459_Selumetinib_30min_R1 2 GGDISVCEWYQR 12 0 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 ; 211.86 6.163e-05 14706600.0 2948.3 3372.0 3151.6 3954.2000000000003 3921.5 3397.2 3101.0 3117.1 1585.51 2523.9 False True 3016.9896536068536 2977.2046723997305 2723.6300304996216 3263.6731995269224 3566.8010173970574 3363.0272524108063 2867.0890733705755 3034.4243822322314 2690.49466893131 2847.8671498678805 1.0593856717462466 1.0454155744371187 0.9563753810025786 1.1460061259101684 1.2524464203193362 1.180893305562665 1.0067495857394846 1.0655077019210695 0.9447402309676309 1.0 11.475666132266557 -7.297744123442785 23.580603459884525 1.009708281903276 1.1055368653739488 0.28057890313852196 0.08020589372111872 510.3557464796528 331482.5990968023 0.03833997177647947 0.025850252954720324 5.0379734744844033e-08 7.297744123442785 0.09582858347067269 GGDLMAYDRR ddPTM_A459_Selumetinib_30min_R1 4 GGDLMAYDRR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;;; 128.27 0.004256899999999999 91140000.0 13815.0 13926.5 21638.0 22705.0 19605.0 15380.3 15901.9 15628.7 9506.1 12107.2 False True 14136.862620689451 12295.978905745797 18699.67844902615 18739.997975635724 17831.731211543884 15225.58814619508 14702.406880306866 15214.17610682779 16131.157401926155 13661.277054114813 1.0348126726872426 0.9000607232427231 1.3688089609011886 1.3717603340744184 1.3052755713034103 1.1145069444008597 1.0762102856173656 1.1136715876972307 1.180794250641993 1.0 13.73780473239576 -6.967480333166944 24.832587183446044 1.101172581020426 1.2001284237206415 0.10763351076165695 0.14272046949060468 495.6721456904102 378502.34337651916 0.05647365049104214 0.04980482091048289 1.0777540582039409e-07 6.967480333166944 0.09895584270021551 GGDLMAYDRR ddPTM_A459_Selumetinib_30min_R2 3 GGDLMAYDRR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;; 131.52 0.0035128 54305400.0 166449.0 176855.0 191549.0 204388.0 215396.0 125691.0 121140.0 137369.0 114703.0 170993.0 False True 157198.43092814018 190419.20982154613 179224.9458827819 176550.00181103378 188336.02881532803 143003.7943407038 126773.25003435618 137768.72104733792 137646.8050695974 166055.98779683118 0.9466592142432817 1.1467169136624165 1.0793043253704462 1.0631956375282414 1.1341718616359464 0.8611781859722419 0.7634367884972793 0.8296522328113659 0.8289180468337445 1.0 17.34131022021657 -6.805632092791501 7.49879029466876 0.8389833541397349 1.0776380505060907 0.6694648164884255 0.0758706039821281 0.11724999877214548 16.41755584967369 0.025348489690997067 0.02252886843431145 1.5644724049164103e-07 6.805632092791501 0.23865469636635583 GGDSGLDGLGGPGVQLGS(ph)PDKK ddPTM_A459_Selumetinib_30min_R2 2 GGDSGLDGLGGPGVQLGSPDKK 22 1 Q9Y3Y4-2 Q9Y3Y4-2 1 GGDSGLDGLGGPGVQLGS(1)PDKK;GGDSGLDGLGGPGVQLGS(1)PDKK 122.59 1.6665e-05 10375400.0 72997.0 59098.0 59263.0 56768.0 60714.0 51855.0 58363.0 57794.0 40912.0 52063.0 True False 68940.11897014365 63630.626569979446 55450.08310067564 49036.10046973782 53086.56452995331 58997.555557177504 61076.99514409053 57962.17097168823 49095.54317679033 50559.80591408081 1.3635360683009259 1.2585219705572175 1.096722625773231 0.9698633051137042 1.0499756391503237 1.166886511736921 1.2080148260039245 1.1464080987610334 0.9710389960796371 1.0 15.625703304944794 -5.10854712052274 2.7789044725324787 1.0838402345735738 1.3542992157231344 0.6053559092670102 0.07786226502342918 0.21662163432190623 3.060975389946464 0.022577702931086557 0.09275853967328733 7.788483056965632e-06 5.10854712052274 0.2704589811495606 GGDSIGETPTPGAS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 GGDSIGETPTPGASK 15 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GGDSIGET(0.037)PT(0.029)PGAS(0.933)K;GGDSIGETPTPGAS(1)K 135.55 0.00040928 14338400.0 9689.2 9470.4 9417.3 11074.6 7913.700000000001 7650.4 7148.2 8870.4 4920.3 7920.9 True False 9914.939508098749 8361.601165330489 8138.482385526112 9140.629005988785 7197.907232277212 7573.443922007419 6609.005518951165 8635.128176880044 8349.389735506385 8937.624671099684 1.1093483865080247 0.9355507165531576 0.9105867257821149 1.0227134549010015 0.8053490157795564 0.8473665208270134 0.7394588341040723 0.9661547105241755 0.9341844217854225 1.0 13.125675745761908 -1.5228787452885935 0.8429037463605679 0.886194869008516 73.64719621615944 0.34816751605071183 0.08311522573630149 715.5532417150242 2.051433433185971 0.029414572453916682 99785.6102136523 0.0299999999994297 1.5228787452885935 72.76100134715092 GGDSIGETPTPGAS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GGDSIGETPTPGASK 15 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GGDSIGET(0.036)PT(0.017)PGAS(0.947)K 91.355 0.01462 3862700.0 28518.0 27942.0 27778.0 26794.0 23099.0 22917.0 23582.0 26813.0 13269.0 24772.0 True False 26933.08372659916 30085.06155230917 25990.793722399612 23144.610977771896 20197.09711231993 26073.608730186817 24678.60972684652 26891.021390868907 15923.170766836893 24056.76799461438 1.1195636808996414 1.2505861784527477 1.0803942461521931 0.962083143627328 0.8395598742458455 1.0838367288583384 1.0258489308443826 1.1178152192717257 0.6618998350236255 1.0 14.554155210286659 -5.563330056927502 3.521698468571992 0.964653739586122 1.184038637199861 0.349639511784252 0.12613008053224276 0.25502041769191974 6.570723433425296 0.03444620612021157 0.06771287503468547 2.733190755110963e-06 5.563330056927502 0.21938489761373903 GGDVS(ph)PSPYSSSSWR ddPTM_A459_Selumetinib_30min_R1 2 GGDVSPSPYSSSSWR 15 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YFE7 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 GGDVS(0.993)PS(0.007)PYSSSSWR;GGDVS(0.995)PS(0.005)PYSSSSWR 217.39 3.2184e-09 213270000.0 5720.700000000001 6541.0 6643.6 6883.4 6757.5 5602.4 6383.200000000001 6361.400000000001 3533.5 4629.0 True False 5853.981179455533 5775.176679171599 5741.435610682598 5681.343407420871 6146.285318133526 5546.044942572203 5901.7100848561995 6192.675007260636 5996.091423370895 5223.177240278301 1.1207701577332692 1.1056826934067217 1.099222819093285 1.0877179054176913 1.1767330564118557 1.0618144258640358 1.129908064261236 1.1856145641595495 1.147977782015954 1.0 12.35071194478276 GGDVS(ph)PSPYSSSSWR ddPTM_A459_Selumetinib_30min_R2 3 GGDVSPSPYSSSSWR 15 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YFE7 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 GGDVS(0.993)PS(0.007)PYSSSSWR;GGDVS(0.994)PS(0.006)PYSSSSWR;GGDVS(1)PSPYSSSSWR 205.28 3.7665e-06 200987000.0 150714.0 142774.0 176863.0 165224.0 180612.0 129772.0 134643.0 142306.0 126186.0 153610.0 True False 142337.91923594446 153724.30670923257 165483.82713387464 142720.2061727022 157921.90586823373 147646.91504707435 140904.16629004307 142720.08689997348 151426.72593142523 149174.88017328878 0.9541681486225954 1.0304972695849257 1.109327702771677 0.9567308249680608 1.0586360497476786 0.9897572223658603 0.9445569262489901 0.956730025418374 1.0150953414912791 1.0 17.186645092466065 -6.984907361109394 22.58550750733805 0.9742993582893418 1.02365149469021 0.16098526385160383 0.04629863575938792 123.78049092644396 185229.4854222352 0.01618287375808025 0.014263286740599365 1.035362995297327e-07 6.984907361109394 0.04935213640086822 GGEKT(ph)PVSGSLK ddPTM_A459_Selumetinib_30min_R1 1 GGEKTPVSGSLK 12 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H7C477 A0A0C4DG98 THOC2 THO complex subunit 2 1 GGEKT(0.997)PVS(0.003)GSLK 142.1 0.0097048 9396300.0 3700.7 5474.3 4864.2 4993.7 3901.8 4437.7 4397.1 4237.2 2046.6 3729.6 True False 3786.9191096913087 4833.366411066977 4203.668357138044 4121.644038358604 3548.8828789187414 4393.060767109215 4065.4232068744823 4124.815691634663 3472.9307222501384 4208.330489380418 0.8998625747781628 1.148523487702265 0.9988921658472073 0.979401225440691 0.8432994718153028 1.0438963332834619 0.9660418109113442 0.980154886134418 0.8252514223904144 1.0 12.039032291732372 -5.761991448865655 3.3766358645071537 0.9463494024134185 1.0324591981475248 0.12168750000236817 0.0844381465029705 0.42492185684736083 10.126102712373418 0.023346293435858225 0.04002989941662776 1.729850419140616e-06 5.761991448865655 0.08610979573410638 GGEPGPLLTASTFS(ph)DPAGPR ddPTM_A459_Selumetinib_30min_R1 1 GGEPGPLLTASTFSDPAGPR 20 0 E5RFT3 E5RFT3 IKBKB 1 GGEPGPLLT(0.005)AS(0.005)T(0.005)FS(0.985)DPAGPR 64.476 0.017996 29513000.0 7942.2 7429.1 7177.1 6386.0 3651.0 7932.2 6833.9 5331.0 3674.4 3878.8 True False 8127.237807169002 6559.297518305111 6202.489240988331 5270.804980066492 3320.767694636405 7852.4092698613495 6318.413420995541 5189.604562471539 6235.188432442062 4376.681762711488 1.8569405425844647 1.4986919026622183 1.4171670633749025 1.2042924904828054 0.7587409536897853 1.794146729324122 1.443653837212302 1.1857395268456576 1.4246382923164997 1.0 12.09562177120946 -4.78228190062858 1.5355890008094777 1.2826257130895315 2.07151526333473 0.3214681592694326 0.26240841738795034 1.4240943180726033 3.168434521350166 0.07623045760008748 1.7196941046108045 1.6508898574561633e-05 4.78228190062858 0.7888895502451982 GGET(ph)PEGLATSVVHYGAGAK ddPTM_A459_Selumetinib_30min_R2 2 GGETPEGLATSVVHYGAGAK 20 0 Q9ULL5;Q9ULL5-2 Q9ULL5 PRR12 Proline-rich protein 12 1 GGET(1)PEGLATSVVHYGAGAK;GGET(0.414)PEGLAT(0.235)S(0.35)VVHYGAGAK 103.92 0.0017718 4640300.0 30471.0 32521.0 46185.0 47676.0 50804.0 39609.0 31320.0 33521.0 34908.0 38654.0 True False 28777.54380507759 35015.25612850352 43213.50738242589 41182.446554312635 44421.54732647741 45064.780215297316 32776.442059402616 33618.5405602997 41890.57541101381 37537.95858484681 0.7666251679625009 0.9327959603705874 1.1511949240593535 1.0970880704987782 1.1833767471950205 1.200512279149056 0.8731546225487523 0.8955878749855808 1.115952411645636 1.0 15.196062574214807 -4.936670200546894 3.331863068366934 1.0640327530522953 0.7666204672941895 0.4313545000249246 0.10687207343094644 0.27317027980079056 5.64516808834271 0.030304381845937835 0.17056660389345052 1.1569905172107284e-05 4.936670200546894 -0.29741228575810574 GGET(ph)PGSEQWK ddPTM_A459_Selumetinib_30min_R1 1 GGETPGSEQWK 11 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3;D6RHI8 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 GGET(0.968)PGS(0.032)EQWK 105.65 0.027062 30985000.0 6569.8 6946.0 5466.2 5449.4 5121.7 5609.8 5006.7 4061.9 3377.6 4486.5 True False 6722.863557394535 6132.759090892209 4723.920063687344 4497.764587907039 4658.4431393095765 5553.37050529087 4629.040588082705 3954.165217089315 5731.540509856381 5062.38597721076 1.3280029590115636 1.211436488347575 0.933141029734382 0.8884673369740147 0.9202070249641958 1.096986782574534 0.9143989827960892 0.7810872649556355 1.1321816502451492 1.0 12.305601793331377 -5.139626034400189 3.3079489740744075 0.9494723280623404 1.3100733475141588 0.6306338176048121 0.09675658218948513 0.1516637217866827 3.0148425597155977 0.02514389760975628 0.0859085025443687 7.250600315599258e-06 5.139626034400189 0.36060101945181844 GGET(ph)PGSEQWK ddPTM_A459_Selumetinib_30min_R2 3 GGETPGSEQWK 11 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3;D6RHI8 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 GGET(0.982)PGS(0.018)EQWK;GGET(1)PGSEQWK;GGET(0.999)PGS(0.001)EQWK 176.99 0.00015727 75793000.0 277319.0 242135.0 251151.0 258208.0 270511.0 280701.0 276368.0 228355.0 172297.0 265197.0 True False 261906.7201759153 260705.97591326243 234992.21809253315 223039.62496635583 236526.98978097667 319365.01480002503 289219.65961280273 229019.4752437947 206761.2143804124 257540.07354544502 1.0169552123300911 1.0122928533964979 0.9124491379438349 0.866038523231992 0.9184084889190636 1.2400594998807846 1.1230083754781859 0.8892576292729154 0.8028312314041788 1.0 17.97443740928449 -7.90085340341709 12.937773805207037 0.882978205627353 1.0083229369777473 0.17941040250920393 0.11161725726910925 0.9916429829803481 122.22915525014315 0.06741933339518867 0.03238148280122706 1.2564540095634585e-08 7.90085340341709 0.12534473135039437 GGFDS(ph)PFYR ddPTM_A459_Selumetinib_30min_R1 2 GGFDSPFYR 9 0 A0A2R8Y6S1;A0A2R8YFV7;A0A2R8Y5N2;A0A2R8Y5S3;Q92574-2;Q92574;A0A2R8YEH9 A0A2R8Y6S1 TSC1 Hamartin 1 GGFDS(1)PFYR;GGFDS(1)PFYR 115.23 0.0082322 36028000.0 5759.5 7030.5 5673.8 7085.4 7521.4 5972.200000000001 6715.0 6241.700000000001 3013.8999999999996 5382.4 True False 5893.68514396387 6207.365791609224 4903.329123952514 5848.067899430489 6841.090698011021 5912.125090323741 6208.482143722485 6076.149840101033 5114.368173453384 6073.283469015758 0.9704281339792307 1.0220774023273438 0.8073604910701052 0.9629170002134335 1.1264237430892872 0.97346437400556 1.0222612159298134 1.0004719639878328 0.8421092477480263 1.0 12.56826099285865 -4.388706341861084 17.20715676053763 0.9751958142230436 0.0005769131178770984 0.0 0.08635482050088428 3302.0950927722906 425154.46142683085 0.021331209438169005 499.7476423124915 4.0859557418196626e-05 4.388706341861084 -0.9746189011051665 GGFDS(ph)PFYR ddPTM_A459_Selumetinib_30min_R2 4 GGFDSPFYR 9 0 A0A2R8Y6S1;A0A2R8YFV7;A0A2R8Y5N2;A0A2R8Y5S3;Q92574-2;Q92574;A0A2R8YEH9 A0A2R8Y6S1 TSC1 Hamartin 1 GGFDS(0.999)PFY(0.001)R;GGFDS(0.989)PFY(0.011)R;GGFDS(1)PFYR;GGFDS(1)PFYR 125.68 0.0049856 52409300.0 140766.0 114161.0 123677.0 162812.0 151321.0 115846.0 117427.0 124888.0 101752.0 109891.0 True False 132942.7892509453 122916.78161452882 115719.75646933587 140636.7247336343 132310.70315309614 131802.73495471574 122887.58817718632 125251.40340367869 122105.24318842315 106718.16129889275 1.2457372543985596 1.1517887875735369 1.0843492341030103 1.3178330944040868 1.2398143066063951 1.2350544026481765 1.15151523116114 1.1736653056913025 1.1441842859945344 1.0 16.703446189364477 -8.85403583257171 0.8499552914272783 0.9996846679476407 1.2061045086299351 0.5128853827830102 0.060076458998854554 1.0149155309208313 1.351877227440593 0.06270060539681643 0.021290147535861715 1.3994718508216798e-09 8.85403583257171 0.20641984068229446 GGFFSS(ph)FMK ddPTM_A459_Selumetinib_30min_R1 1 GGFFSSFMK 9 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 GGFFS(0.322)S(0.678)FMK 131.52 0.0035843000000000008 7335500.0 3771.1 3362.9 2952.5 2927.6 2357.0 3351.9 2403.7 2763.9 2318.4 2018.3 True False 3858.959292716755 2969.1701046302046 2551.5667169216035 2416.34961785823 2143.8097661621487 3318.1829292816938 2222.3869737700265 2690.5923935875244 3934.1554707635696 2277.368464906826 1.6944817460070682 1.3037723804398436 1.120401356319824 1.0610270823948948 0.9413539351217188 1.4570250622212997 0.9758574460022441 1.1814479892245302 1.727500635662191 1.0 11.153152014646956 -4.788725530843329 2.9640283482428718 1.1796937452435003 1.775960983792795 0.309242795695597 0.22932026297251398 0.46862499067091334 5.978544520346661 0.05800108300490792 0.6703335201333795 1.626576408712661e-05 4.788725530843329 0.5962672385492946 GGGAGGNSDS(ph)DNLDSTDCNSESSSGGK ddPTM_A459_Selumetinib_30min_R1 1 GGGAGGNSDSDNLDSTDCNSESSSGGK 27 0 Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 GGGAGGNS(0.409)DS(0.591)DNLDSTDCNSESSSGGK 123.51 1.1381e-09 0.0 1168.0 986.97 976.23 982.1 656.65 924.81 786.21 805.24 516.78 653.38 True False 1195.212127467628 871.4150935700952 843.6633280475455 810.5946713002352 597.2561234409739 915.5072510602961 726.9055467186975 783.8824194118522 876.9379158821598 737.2476874601506 1.621181249934041 1.1819841667759678 1.1443417760373062 1.099487573969568 0.8101159672654199 1.2417906039342859 0.985971959061571 1.063255175628099 1.189475302260015 1.0 9.526005581737891 -4.010854969200888 1.2052960937904285 1.0570985213737711 3.971956437449737 0.6852582565187795 0.11296074262174259 4.544820002194266 1.4439634705387236 0.032662384755647755 25.987893117672655 9.753152857404674e-05 4.010854969200888 2.914857916075966 GGGAPWPGGAQT(ph)YSPSSTCR ddPTM_A459_Selumetinib_30min_R1 1 GGGAPWPGGAQTYSPSSTCR 20 0 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 GGGAPWPGGAQT(0.796)YS(0.139)PS(0.06)S(0.004)T(0.001)CR 202.84 1.4309e-15 3114500.0 749.48 792.0 936.13 875.79 682.22 534.63 715.81 575.96 442.19 572.57 True False 766.9414257657857 699.2722718091895 809.0086877940128 722.8497171143805 620.5133214557236 529.252107605201 661.8158753980626 560.6836698182534 750.3641337202135 646.0649368040933 1.187096500793922 1.0823560171339717 1.252209556203371 1.1188499420663818 0.9604503914501743 0.8191933619293232 1.0243798071938168 0.8678441405469275 1.1614376372629969 1.0 9.335535369085457 -6.188141485735988 4.121287884960977 0.9602188564168079 1.1666562583572155 0.4873894547898967 0.09483516819255677 0.1857400128228981 6.084809507481561 0.027813491727007988 0.03613763727729438 6.484231539287554e-07 6.188141485735988 0.2064374019404076 GGGAPWPGGAQT(ph)YSPSSTCR ddPTM_A459_Selumetinib_30min_R2 1 GGGAPWPGGAQTYSPSSTCR 20 0 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 GGGAPWPGGAQT(0.871)Y(0.014)S(0.115)PSSTCR 148.19 4.5861000000000014e-05 11847000.0 27157.0 30722.0 33700.0 40012.0 42294.0 29095.0 30676.0 31176.0 27068.0 28126.0 True False 25647.722658084487 33078.27861320025 31531.778689785722 34562.29657545007 36980.6496068427 33102.57215188661 32102.49478334085 31266.71699853535 32482.35634311108 27313.92929987586 0.9389979148185411 1.2110406470646677 1.1544211872119414 1.2653725575692674 1.3539117422776215 1.2119300664674804 1.1753158775104084 1.1447169191683253 1.1892231244538922 1.0 14.73734925036003 -10.679034216334937 12.59799617833669 1.000000011188702 1.1897499737322397 0.22859437545341565 0.09998721200060705 0.0 0.0 0.09930677226392091 0.02408543008137084 2.0939474755584328e-11 10.679034216334937 0.1897499625435377 GGGAPWPGGAQTYS(ph)PSSTCR ddPTM_A459_Selumetinib_30min_R2 1 GGGAPWPGGAQTYSPSSTCR 20 0 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 GGGAPWPGGAQT(0.02)YS(0.971)PS(0.007)S(0.001)TCR 159.5 1.081e-06 10535000.0 38715.0 41546.0 51683.0 55920.0 63078.0 41824.0 45736.0 41002.0 33630.0 46318.0 True False 36563.375288424395 44732.44460855475 48357.772048195664 48303.599532619446 55153.57771552521 47584.87635952929 47862.81462416473 41121.30903175352 40356.93970071027 44980.678991383415 0.8128684605990173 0.9944813109007045 1.0750787478654817 1.0738743970910838 1.2261615198403415 1.057895910567396 1.0640749694626312 0.9141993841318135 0.8972061028345331 1.0 15.457017818568874 -12.471232534192024 16.91660089098721 1.0000100159804248 1.0209246847170852 0.0 0.11054789723621752 0.0 0.0 0.0 0.0271853084954176 3.378838746808753e-13 12.471232534192024 0.02091466873666037 GGGDRYEDRYDR ddPTM_A459_Selumetinib_30min_R1 1 GGGDRYEDRYDR 12 2 E7EX17;P23588;P23588-2;F8VX11;F8VP89 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 159.34 0.0046702 8915900.0 242.89 110.0 412.13 482.88 226.51 181.45 258.23 145.67 148.94 54.919 False True 248.54886441833227 97.1211488623874 356.1650096680446 398.55407278022375 206.0222104935885 179.62477774341818 238.75150319783424 141.8063583971542 252.74030185279778 61.96838860636082 4.010897652949776 1.5672692326942044 5.747527371261767 6.431570704733699 3.3246339807590397 2.898651744592571 3.8527950874186088 2.2883660780328623 4.078535968689929 1.0 5.953460548595664 -6.502563689047444 24.530703722109184 2.984415988985719 4.3964247952574915 0.2177450085463134 1.4318162594585953 1124.7716868040832 1358178.5389926555 0.4653613024410808 0.5210345861520662 3.1436653696518955e-07 6.502563689047444 1.4120088062717726 GGGDVLEPVSSDSLS(ph)TK ddPTM_A459_Selumetinib_30min_R2 2 GGGDVLEPVSSDSLSTK 17 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 GGGDVLEPVSSDS(0.001)LS(0.962)T(0.037)K;GGGDVLEPVS(0.04)S(0.103)DS(0.026)LS(0.639)T(0.192)K 184.22 6.2371e-08 7446500.0 48383.0 34462.0 43394.0 42239.0 40827.0 34855.0 44922.0 43176.0 38860.0 34780.0 True False 45694.06655249484 37105.12458720487 40602.07728381488 36485.97533366081 35697.94726198907 39655.959867812606 47010.96201125432 43301.63501182843 46633.08583911985 33775.81103070762 1.3528636369664557 1.0985709433733617 1.2021051765981603 1.0802397994378052 1.0569086625198703 1.1740934905089027 1.3918529437683622 1.2820309473090168 1.3806651688311173 1.0 15.043702791763083 -7.058627394341998 11.253818612860629 1.2866517722215922 1.149209562752646 0.12454918055925746 0.12736173480507634 1.502423286781666 285.7369942845786 0.04632673060589313 0.03591819184934568 8.737206609996168e-08 7.058627394341998 -0.13744220946894625 GGGESLQEAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 GGGESLQEASPR 12 0 P98175-5 P98175-5 RBM10 RNA-binding protein 10 1 GGGESLQEAS(1)PR;GGGESLQEAS(1)PR 165.51 0.00050849 30743000.0 88711.0 102330.0 100469.0 95025.0 117111.0 91493.0 97744.0 101734.0 70724.0 95252.0 True False 83780.79775826985 110178.38195718972 94004.93392237606 82082.4310727319 102398.4691943764 104095.33025923898 102289.28967606154 102030.02909702966 84870.77619366752 92501.82726558256 0.9057204623399092 1.1910941136422732 1.0162494806992075 0.8873601041097765 1.1069886100777182 1.1253326916491093 1.1058083142766266 1.10300555257239 0.9175037802225736 1.0 16.49719424421577 -4.6987972510140725 23.41479048833161 1.0532741173772333 0.9057095654848776 0.18527638365037402 0.0908158008662417 34988.93170967323 13074517.336577855 0.022965712098888636 80.56423742380383 2.0007957166970504e-05 4.6987972510140725 -0.14756455189235573 GGGGEGGGEAS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 1 GGGGEGGGEASPDR 14 0 A0A0D9SGA5;A0A0D9SGD0 A0A0D9SGA5 SLC12A5 1 GGGGEGGGEAS(1)PDR 77.91199999999998 0.039185000000000005 1655300.0 3176.7 2601.8 2548.4 4047.0 2969.8 3116.4 4509.1 7148.8 5165.4 4409.1 True False 3000.1517313376653 2801.3496938944236 2384.438718488128 3495.791618535603 2596.707173651142 3545.6558121374583 4718.782084612144 7169.601824452452 6198.624333334786 4281.797826782431 0.7006757097618823 0.6542461384729847 0.5568779318756208 0.8164307984533042 0.6064525413621513 0.8280764191993276 1.1020562566257561 1.6744372608176294 1.447668615870348 1.0 12.064000962406935 -7.3572027155711615 2.4756748721761563 1.4176110781617646 0.6752279238994011 0.75403541362286 0.1754657813910983 0.12813164553144257 1.5324775877563048 0.08282993692880877 0.05106581511957534 4.3933649853783494e-08 7.3572027155711615 -0.7423831542623635 GGGGGGQGAEGPPGT(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 GGGGGGQGAEGPPGTPR 17 0 Q8TER5;Q8TER5-4;Q8TER5-3;G3V485;G3V3N2;G3V5C1 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 GGGGGGQGAEGPPGT(1)PR;GGGGGGQGAEGPPGT(1)PR;GGGGGGQGAEGPPGT(1)PR 207.05 1.2954e-08 18308300.0 2751.3900000000003 2772.48 2465.9300000000003 3006.79 3224.21 2411.48 2483.35 2479.88 1579.26 2623.81 True False 2815.492033727018 2447.8767527090167 2131.0702503839107 2481.710570938637 2932.5807747805097 2387.2227006486546 2296.028910143444 2414.105526614503 2679.8888754132504 2960.601571573692 0.950986468682599 0.8268173523287906 0.7198098760891867 0.8382453737668918 0.9905354381142586 0.8063302821864473 0.7755278292725495 0.815410472585576 0.9051838994967396 1.0 11.531674634890098 -8.559525972571734 3.584986728722369 0.9997715553937945 0.838032143582761 0.3056616290131686 0.07458031028639966 0.30062919626882123 11.127595335906827 0.07535494834339544 0.01985107600471946 2.757236553484966e-09 8.559525972571734 -0.16173941181103346 GGGGGGQGAEGPPGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 GGGGGGQGAEGPPGTPR 17 0 Q8TER5;Q8TER5-4;Q8TER5-3;G3V485;G3V3N2;G3V5C1 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 GGGGGGQGAEGPPGT(1)PR;GGGGGGQGAEGPPGT(1)PR;GGGGGGQGAEGPPGT(1)PR 166.36 3.4818000000000007e-06 28557000.0 40886.7 29246.2 40015.1 36487.1 45931.2 32099.8 36030.2 34947.3 29731.7 29264.8 True False 38614.38089642828 31489.289498645187 37440.57203114669 31517.494036241722 40160.912025862104 36521.25607702801 37705.675692486875 35048.99085716304 35678.87077310757 28419.849184918094 1.3587116752512622 1.1080033990946014 1.3174092440650857 1.108995822995693 1.4131289636531492 1.2850615722622902 1.3267373604676482 1.2332574542922947 1.2554208342541702 1.0 14.794611278227677 -9.262207963971466 1.500147130911028 0.9999138978979907 1.2670458513527745 0.42454661133937954 0.09354823975513944 7.792177051155334 14.768956475568494 0.0866852149837997 0.024739659618507107 5.467540844128481e-10 9.262207963971466 0.2671319534547838 GGGGGQDNGLEGLGNDS(ph)R ddPTM_A459_Selumetinib_30min_R1 4 GGGGGQDNGLEGLGNDSR 18 0 P08621;P08621-4;P08621-2 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 GGGGGQDNGLEGLGNDS(1)R;GGGGGQDNGLEGLGNDS(1)R;GGGGGQDNGLEGLGNDS(1)R;GGGGGQDNGLEGLGNDS(1)R 321.88 3.977999999999998e-127 152106000.0 7756.049999999999 12150.6 7161.099999999999 6728.92 9608.8 7940.66 13976.7 13640.5 5896.71 11175.9 True False 7936.75087435385 10728.002103339315 6188.661953106624 5553.840439472129 8739.68573657143 7860.784169942421 12922.42626629428 13278.709629411567 10006.286191341553 12610.435627484618 0.6293795955038692 0.8507241478603235 0.49075718999099055 0.44041622379543 0.6930518496540409 0.623355481297548 1.0247406709828226 1.0529937285013722 0.7934925078664781 1.0 13.622330493974998 -7.25583845027847 24.494558052647236 0.972222876785436 0.6208182939682982 0.6582040930726469 0.12231643034021385 224.2513103048886 980721.8657569365 0.049983793623725147 0.03758967090852237 5.548320621057958e-08 7.25583845027847 -0.3514045828171377 GGGGGQDNGLEGLGNDS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 GGGGGQDNGLEGLGNDSR 18 0 P08621;P08621-4;P08621-2 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 GGGGGQDNGLEGLGNDS(1)R;GGGGGQDNGLEGLGNDS(1)R;GGGGGQDNGLEGLGNDS(1)R 210.98 1.0331e-11 148822500.0 75934.0 71173.0 97828.0 90571.0 88185.0 70802.0 90002.0 94790.0 78375.0 63973.2 True False 71713.89226788632 76631.74024273476 91533.85298707278 78235.07355631016 77106.41191609732 80554.33282343607 94187.27133557966 95065.8232066708 94052.18998046864 62126.127493664826 1.1543274168376128 1.2334865109779956 1.4733551998135848 1.2592942247090486 1.2411269626287278 1.2966256883088427 1.5160653840074645 1.5302068073752855 1.5138910757001458 1.0 15.92291250915811 -7.151805116356132 6.834782515396137 1.4337305697775968 1.279727178809212 0.0806321412428439 0.16370317311833554 0.45868912149039237 25.10214897934468 0.060675197500751066 0.046917821991687626 7.05009361198798e-08 7.151805116356132 -0.1540033909683849 GGGGGS(ph)GGGNGGASSGK ddPTM_A459_Selumetinib_30min_R1 1 GGGGGSGGGNGGASSGK 17 0 A0A1B0GVL4 A0A1B0GVL4 1 GGGGGS(1)GGGNGGASSGK 87.29799999999999 0.010705 8937200.0 1064.7 1648.9 1907.1 1752.5 1416.9 1151.8 1276.1 1312.5 791.96 1301.8 True False 1089.5054384544371 1455.8460214471866 1648.126294950447 1446.4587734992995 1288.741645174012 1140.213937750726 1179.8427496059958 1277.6882363991544 1343.8982775301579 1468.8987106058103 0.7417158382589213 0.9911139624098108 1.1220149374838233 0.9847232917120228 0.8773522883974096 0.7762372786619668 0.803215865796083 0.8698273251749292 0.9149019383207851 1.0 10.520519201492402 -6.319406170084453 5.315489657725188 0.857575701477391 0.9736753237740621 0.1258001172932116 0.10474198876993028 0.353764133063451 21.42031011243067 0.033895320712074246 0.03896653453134247 4.792849918995861e-07 6.319406170084453 0.11609962229667103 GGGGNFGPGPGS(ph)NFR ddPTM_A459_Selumetinib_30min_R2 3 GGGGNFGPGPGSNFR 15 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 GGGGNFGPGPGS(1)NFR;GGGGNFGPGPGS(1)NFR;GGGGNFGPGPGS(1)NFR 139.77 0.00039221 24402300.0 70857.0 73637.0 80818.0 68248.0 76669.0 53315.0 56613.0 62405.0 49122.0 71797.0 True False 66919.05160304505 79284.72111972602 75618.25786798529 58952.50466563327 67037.15479044366 60658.657304617045 59245.6166765313 62586.58821829611 58947.772583356826 69724.03405899131 0.9597702213619331 1.1371218287892768 1.0845364713695003 0.8455119595598185 0.961464087601782 0.8699820388088225 0.8497158472845311 0.897632919021059 0.84544409082072 1.0 16.089368422170466 -5.755636823761884 24.979643451916857 0.8911686508378324 1.0681407849765172 0.5867633079243482 0.06319919118558642 86.09546648909854 370630.5371890399 0.016460364022755834 0.027552128558304845 1.755347787644026e-06 5.755636823761884 0.17697213413868484 GGGGNFGPGPGSNFR ddPTM_A459_Selumetinib_30min_R2 2 GGGGNFGPGPGSNFR 15 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 148.78 0.0041265 11778100.0 20974.0 23154.0 23813.0 23929.0 26750.0 20841.0 18614.9 19578.7 16027.3 24220.0 False True 19808.3490455744 24929.837348155692 22280.897505634046 20669.82892017258 23389.4258519658 23711.65857423848 19480.52973472458 19635.670775571736 19233.20784017822 23520.705668882634 0.8421664436616118 1.059910263710213 0.9472886493839839 0.8787928904496389 0.9944185425911556 1.0081185023971655 0.8282289659572962 0.8348249007490148 0.8177138947673378 1.0 14.521643724150824 -7.269169994098025 24.858447499560675 0.8564273460659788 0.9578407377284237 0.223349547331555 0.07576152456924021 706.3290733609093 2271250.274650081 0.030165338384845752 0.020771001131181927 5.380591310250493e-08 7.269169994098025 0.1014133916624449 GGGQLDLLGVSLAS(ph)LKK ddPTM_A459_Selumetinib_30min_R1 1 GGGQLDLLGVSLASLKK 17 1 E7EXA6;A0A0D9SF58;Q8WVB6;Q8WVB6-2;F8WCC1;H0Y7D3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 GGGQLDLLGVS(0.004)LAS(0.996)LKK 95.591 0.0032511 11483000.0 2624.2 2754.1 3645.6 3228.2 2618.0 2798.6 3221.7 3090.8 1831.2 2620.3 True False 2685.3387541956763 2431.648691653645 3150.5475438473836 2664.4554708190817 2381.2023622454412 2770.4486249254915 2978.68457519445 3008.8219436666745 3107.4126544436917 2956.6410288833963 0.90823969767132 0.8224362267515378 1.0655833809616104 0.9011765191614549 0.8053741861062941 0.937025698372243 1.007455604551148 1.017648714968616 1.0509942276006485 1.0 11.529743378547378 -7.216088208436416 3.520007227478223 1.022454491492089 0.9030612012889526 0.41361361955187337 0.06649175263764565 0.2578153459872772 6.5909376693968325 0.028952937631962817 0.02092774254467849 6.08011497083783e-08 7.216088208436416 -0.11939329020313638 GGGQSVQFTDIETLKQES(ph)PNGSR ddPTM_A459_Selumetinib_30min_R1 4 GGGQSVQFTDIETLKQESPNGSR 23 1 Q02241;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23 1 GGGQSVQFT(0.002)DIET(0.009)LKQES(0.984)PNGS(0.006)R;GGGQSVQFT(0.011)DIET(0.249)LKQES(0.733)PNGS(0.007)R;GGGQSVQFTDIETLKQES(0.99)PNGS(0.01)R;GGGQS(0.003)VQFT(0.034)DIET(0.192)LKQES(0.638)PNGS(0.133)R 139.63 1.7647999999999996e-06 218730000.0 9833.199999999999 14403.400000000001 16046.400000000001 18059.199999999997 12931.5 14094.4 12836.699999999999 11525.800000000001 6414.34 10201.5 True False 10062.29442792352 12717.043232041007 13867.387016565908 14905.499733168932 11761.848108241762 13952.623132691288 11868.417384113545 11220.098342925245 10884.666495142166 11510.96189602487 0.8741488781574697 1.1047767638282808 1.204711399605518 1.2948961057994912 1.0217954167934074 1.2121161774942202 1.0310534854790994 0.9747316031686222 0.9455913930964375 1.0 13.490720774673967 -7.492138224467831 5.173013709130513 0.9747011940695134 1.1259130644108324 0.2671930392204793 0.10883943529329529 0.25915686185565123 18.784205343988372 0.05041750771682923 0.03177146031005817 3.2200437732529803e-08 7.492138224467831 0.151211870341319 GGGQSVQFTDIETLKQES(ph)PNGSR ddPTM_A459_Selumetinib_30min_R2 3 GGGQSVQFTDIETLKQESPNGSR 23 1 Q02241;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23 1 GGGQSVQFTDIET(0.002)LKQES(0.965)PNGS(0.033)R;GGGQSVQFTDIET(0.002)LKQES(0.992)PNGS(0.005)R;GGGQSVQFT(0.023)DIET(0.058)LKQES(0.906)PNGS(0.013)R 98.968 3.0987e-05 167376800.0 353624.0 332648.0 358108.0 396580.0 280925.0 285290.0 289164.0 266791.0 236418.0 360988.0 True False 333970.9937490325 358161.0319680959 335067.7211585097 342565.11986134155 245632.68999863518 324586.1078952301 302610.6989675956 267567.31764037226 283708.2060708453 350565.3384805366 0.9526640460137065 1.0216669837368448 0.9557924996544195 0.9771790940488567 0.7006759169725295 0.9258933279088319 0.8632076983971322 0.7632452164269732 0.8092876703114127 1.0 18.41932383369945 -6.133939718352051 14.606472638117 0.8369676603859489 0.9787478740046784 0.4013401085407279 0.0793737511857956 0.9388951030424872 105.19814606366786 0.0224146049397977 0.028939297039137342 7.346158284199181e-07 6.133939718352051 0.1417802136187295 GGGSCSGSAGGGGS(ph)GSLPSQR ddPTM_A459_Selumetinib_30min_R1 2 GGGSCSGSAGGGGSGSLPSQR 21 0 O15234 O15234 CASC3 Protein CASC3 1 GGGSCSGSAGGGGS(0.982)GS(0.018)LPSQR;GGGSCSGSAGGGGS(0.442)GS(0.442)LPS(0.115)QR 279.27 7.7613e-73 38137000.0 2104.6 2393.08 1789.08 1738.6 2194.69 1885.3999999999999 2654.46 2061.19 1096.13 2082.58 True False 2153.6330851612743 2112.89708108729 1546.1327627129906 1434.9861475639836 1996.1806770039896 1866.434587806232 2454.231945081992 2006.5205455112948 1860.0525518323295 2349.899429047049 0.9164788324726874 0.8991436207736473 0.657956993223319 0.6106585370531841 0.8494749402162702 0.794261475506262 1.044398715428112 0.8538750725706571 0.7915455992883209 1.0 11.198383298337518 -7.038624566299349 24.202179726948874 0.9115710240098029 0.7806316758041184 0.25591319175468885 0.11152429177958005 604.0042074564482 378467.3209289937 0.04571396709470877 0.03541900944898463 9.149038048138916e-08 7.038624566299349 -0.13093934820568454 GGGSCSGSAGGGGS(ph)GSLPSQR ddPTM_A459_Selumetinib_30min_R2 1 GGGSCSGSAGGGGSGSLPSQR 21 0 O15234 O15234 CASC3 Protein CASC3 1 GGGSCSGSAGGGGS(0.97)GS(0.03)LPSQR 270.73 5.582599999999998e-60 10267000.0 8332.3 6877.5 8308.3 8535.9 9999.5 7218.9 8530.9 9195.7 8174.7 7714.0 True False 7869.2241228396815 7404.982135352025 7773.753023393077 7373.295694751184 8743.273413335783 8213.237948350377 8927.603753657655 9222.457964569918 9809.868420202092 7491.276776621001 1.0504516596420772 0.9884806497153746 1.037707356862536 0.9842508713283674 1.1671272700298634 1.0963735813342919 1.191733267888217 1.231092941773509 1.3095055372692972 1.0 12.870995910197895 -6.570562334224597 1.2750378896160295 1.1973324749876537 1.0120384893298424 0.42161147015022604 0.08186099669071557 0.3792595131873235 1.288547568543101 0.035423143432313585 0.03808969111673319 2.688051999657866e-07 6.570562334224597 -0.1852939856578113 GGGSCSGSAGGGGSGS(ph)LPSQR ddPTM_A459_Selumetinib_30min_R1 1 GGGSCSGSAGGGGSGSLPSQR 21 0 O15234 O15234 CASC3 Protein CASC3 1 GGGS(0.016)CS(0.003)GS(0.013)AGGGGS(0.182)GS(0.785)LPSQR 82.865 0.0014779 964360.0 196.45 163.19 199.4 124.03 305.61 0.0 0.0 171.78 0.0 157.99 True False 201.02690277484194 144.08363893502727 172.32257522579778 102.37048883145113 277.9676294598277 0.0 0.0 167.22383637992144 0.0 178.2695554529205 1.127656947727855 0.8082346902641968 0.9666405168733745 0.5742454934122855 1.559254628495647 0.0 0.0 0.9380392291609424 0.0 1.0 7.477916532965584 -6.775203763654535 24.999998523543447 0.3595098726542556 0.969845527947246 0.35989114721791526 0.41080439704592314 263.8949317041146 479304.6032840026 0.13876541056264832 0.12300766058467313 1.6780165363104004e-07 6.775203763654535 0.6103356552929904 GGGSGGGEES(ph)EGEEVDED ddPTM_A459_Selumetinib_30min_R1 1 GGGSGGGEESEGEEVDED 18 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 GGGSGGGEES(1)EGEEVDED 162.88 6.493e-06 1980700.0 1564.9 1716.2 1781.0 1836.6 2449.5 1387.9 1637.6 1734.9 835.43 1215.4 True False 1601.359125234666 1515.266506160265 1539.149982332727 1515.8722872518188 2227.94315749435 1373.9389861123743 1514.074513560677 1688.8848162505851 1417.6636926069755 1371.4084289985421 1.1676748453442445 1.104898055254607 1.1223133457453491 1.1053397771215172 1.6245657459764078 1.00184522499667 1.104028881218351 1.2314965990721503 1.0337282917549302 1.0 10.421442579148566 -8.36399518451094 5.08546432039078 1.003981571027853 1.1814311772423314 0.1491119469475788 0.15898113550461954 0.45233930107131415 17.014338805754566 0.1534903784691368 0.04012622714372273 4.325186268066684e-09 8.36399518451094 0.17744960621447836 GGGSGGGEES(ph)EGEEVDED ddPTM_A459_Selumetinib_30min_R2 2 GGGSGGGEESEGEEVDED 18 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 GGGSGGGEES(1)EGEEVDED;GGGSGGGEES(1)EGEEVDED 156.2 2.4135e-05 3715400.0 27333.7 29147.2 31651.0 34235.0 40726.0 25317.4 27599.3 28411.0 27806.4 26479.5 True False 25814.60237947062 31382.696516980384 29614.609119003184 29572.13394133092 35609.63578494055 28804.64204152515 28882.722136975444 28493.67130630575 33368.45697573091 25714.968032996614 1.0038745662194157 1.2204058148822556 1.151648684960552 1.149996916324567 1.3847824247437297 1.1201508010651215 1.1231871686526722 1.1080578155782108 1.2976277836672239 1.0 14.650320739785963 -10.406613391675826 14.843692759067123 0.9999994365412789 1.1746301633673046 0.20983833693017406 0.10085954447258777 0.0 0.0 0.09564582789162444 0.02319752064981267 3.920907604289469e-11 10.406613391675826 0.17463072682602576 GGGT(ph)PDANSLAPPGK ddPTM_A459_Selumetinib_30min_R1 2 GGGTPDANSLAPPGK 15 0 Q9BRQ0;Q5T171 Q9BRQ0 PYGO2 Pygopus homolog 2 1 GGGT(0.962)PDANS(0.038)LAPPGK;GGGT(1)PDANSLAPPGK 189.33 5.0907e-05 150454000.0 11985.2 13281.3 13551.599999999999 14019.3 14035.599999999999 11483.9 12905.2 11669.2 6089.9 10445.2 True False 12264.431840860461 11726.319221691145 11711.367153610432 11571.092429853778 12766.082458186449 11368.382392546935 11931.750373963869 11359.694909096399 10334.115511302221 11785.943164863891 1.0405982507554452 0.9949410970052447 0.993672461320212 0.9817705946817541 1.0831617189742215 0.9645712891640456 1.0123712805212446 0.9638341836707461 0.8768170155537623 1.0 13.524779593786723 -7.915797492622314 4.186258261128232 0.9330195820595023 1.0087393991694815 0.332548053808682 0.041716486883763886 0.2208424932978985 7.179437518728593 0.023896025267789268 0.010589641711016055 1.213954774053372e-08 7.915797492622314 0.07571981710997921 GGGT(ph)PDANSLAPPGK ddPTM_A459_Selumetinib_30min_R2 1 GGGTPDANSLAPPGK 15 0 Q9BRQ0;Q5T171 Q9BRQ0 PYGO2 Pygopus homolog 2 1 GGGT(0.592)PDANS(0.408)LAPPGK 179.55 4.6762e-05 36939000.0 170020.0 150380.0 155810.0 179830.0 177960.0 124950.0 128540.0 144100.0 120500.0 140840.0 True False 160570.9690439857 161913.66245208806 145785.3542331014 155336.843775947 155603.07381741432 142160.72831683204 134517.36469717804 144519.30714296093 144603.3670513107 136773.58325373355 1.173991096994986 1.1838080029804896 1.065888242195496 1.1357225575334682 1.1376690594465857 1.0393873212570925 0.9835039888340871 1.0566317245257661 1.0572463162206684 1.0 17.061430086319625 -6.784642777529165 5.194157058993629 1.0270234599224586 1.1380375968012684 0.7070107197887887 0.03612864404786505 0.11192979713730027 8.050916706301022 0.013379618236810636 0.012225329017039821 1.641939771066356e-07 6.784642777529165 0.11101413687880979 GGGTPDANS(ph)LAPPGK ddPTM_A459_Selumetinib_30min_R2 3 GGGTPDANSLAPPGK 15 0 Q9BRQ0;Q5T171 Q9BRQ0 PYGO2 Pygopus homolog 2 1 GGGT(0.002)PDANS(0.998)LAPPGK;GGGT(0.267)PDANS(0.733)LAPPGK;GGGT(0.302)PDANS(0.698)LAPPGK 168.93 6.2769e-05 151200000.0 497086.0 423051.0 510320.0 554798.0 562480.0 392387.0 430949.0 427122.0 371979.0 474281.0 True False 469459.95011292066 455497.6513766357 477486.5667944045 479233.55532006896 491816.23376499896 446434.7475154608 450988.982409243 428364.8543061462 446385.193961656 460587.27519997145 1.0192638298769696 0.9889497081283325 1.0366907478872402 1.0404837066156505 1.0678024779374744 0.9692728643483125 0.9791607512679086 0.9300405750900622 0.9691652765870499 1.0 18.813115028295563 -6.84482609510033 8.885386649425339 0.9654207182181799 1.0291390293222038 0.6044148568600658 0.02460091700591157 0.20427975521568328 19.67694240316226 0.009106840001065647 0.008036821755238512 1.429466246277476e-07 6.84482609510033 0.06371831110402393 GGGTSSGGSSTNS(ph)LTGSRPPK ddPTM_A459_Selumetinib_30min_R1 3 GGGTSSGGSSTNSLTGSRPPK 21 1 Q5T9C2-3;Q5T9C2-2;Q5T9C2 Q5T9C2-3 FAM102A Protein FAM102A 1 GGGTSSGGSST(0.001)NS(0.989)LT(0.01)GSRPPK;GGGTSSGGSS(0.006)T(0.008)NS(0.985)LT(0.001)GSRPPK;GGGTSSGGS(0.001)S(0.002)T(0.004)NS(0.993)LTGSRPPK 157.53 8.804e-08 24410100.0 4820.8 5713.4 5604.0 5814.8 5076.700000000001 5679.2 5226.3 4527.4 2844.64 3595.56 True False 4933.115260356112 5044.4724719124015 4843.007580568558 4799.354337314538 4617.513381364183 5622.072404301025 4832.07598328173 4407.318644932217 4827.146315714666 4057.085149720253 1.2159259858512617 1.2433735762879494 1.1937160305601417 1.1829562753065377 1.1381356838622363 1.3857417818032935 1.1910215844532903 1.086326385147749 1.1898065082630842 1.0 11.986227866671396 -8.725085821566106 0.7911141279171731 1.0026388491840406 1.2200286696731097 0.44618136038355205 0.07095433365334072 0.8770261378360638 1.133264612417043 0.07167226001468037 0.025614893229290933 1.8832768956215084e-09 8.725085821566106 0.21738982048906919 GGGTSSGGSSTNS(ph)LTGSRPPK ddPTM_A459_Selumetinib_30min_R2 1 GGGTSSGGSSTNSLTGSRPPK 21 1 Q5T9C2-3;Q5T9C2-2;Q5T9C2 Q5T9C2-3 FAM102A Protein FAM102A 1 GGGTSSGGS(0.001)S(0.001)T(0.003)NS(0.58)LT(0.411)GS(0.004)RPPK 73.649 0.0020172 6769100.0 6210.7 5093.8 6121.6 7870.9 8057.0 5893.8 6099.3 4888.9 5056.3 6312.3 True False 5865.534157401969 5484.478080851494 5727.74292069413 6798.869841940171 7044.807629506109 6705.617451410523 6382.929535533666 4903.125889599033 6067.701284826088 6130.047497674972 0.956849707873662 0.8946876974332855 0.9343717031338779 1.1091055729207437 1.1492256189169971 1.0938932290416763 1.0412528676090371 0.7998512069374193 0.9898294078679601 1.0 12.581682537109083 GGHMIAVS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 GGHMIAVSPQK 11 0 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 GGHMIAVS(1)PQK;GGHMIAVS(1)PQK 89.46 0.019319 22362000.0 192190.0 185022.0 196754.0 200919.0 186948.0 154050.0 168929.0 163505.0 128772.0 162992.0 True False 181508.84919752766 199212.5924605024 184095.0618495578 173553.4855953926 163461.92090367503 175268.98917333325 176784.53322646336 163980.77248028995 154529.9981903025 158285.99745592542 1.14671450485106 1.2585610582260947 1.1630533642170016 1.0964550774222361 1.0326998188781091 1.1072930770274656 1.1168677966962228 1.0359777561874999 0.9762708052133999 1.0 17.27217410960607 -5.652829289012818 0.31693754209933533 0.9905115445911455 1.3033117520751913 0.6606319312179737 0.04702106335847767 2.7370760166360255 0.34055851940773946 0.058385417059996184 0.31669580157240435 2.224183993470235e-06 5.652829289012818 0.3128002074840458 GGIDNPAIT(ph)SDQELDDK ddPTM_A459_Selumetinib_30min_R2 2 GGIDNPAITSDQELDDK 17 0 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GGIDNPAIT(0.824)S(0.176)DQELDDK;GGIDNPAIT(0.711)S(0.289)DQELDDK 235.02 9.7472e-17 26381000.0 223409.0 181606.0 186520.0 190751.0 178533.0 155420.0 190426.0 177865.0 141765.0 180286.0 True False 210992.82215708657 195534.5962446727 174519.50626762133 164770.3847361707 156104.08843472955 176827.6942377114 199281.18632196076 178382.55770286408 170121.9612450551 175080.6747407171 1.2051177119893615 1.1168256949788804 0.9967948006030544 0.9411112047642307 0.8916123305208263 1.0099783685411399 1.138224916125569 1.0188592085736294 0.9716775509175668 1.0 17.41766032351733 -5.055421295701075 2.6435760873794965 0.9963034379008555 1.2033930385449498 0.5686816034489759 0.05979274010953897 0.25477517040729863 3.212388940652542 0.018112498466951284 0.0881555633759328 8.8019460904627e-06 5.055421295701075 0.20708960064409432 GGIDNPAIT(ph)SDQELDDKK ddPTM_A459_Selumetinib_30min_R1 2 GGIDNPAITSDQELDDKK 18 1 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GGIDNPAIT(0.5)S(0.5)DQELDDKK;GGIDNPAIT(0.923)S(0.077)DQELDDKK 157.01 2.7438e-05 203330000.0 10314.099999999999 11507.6 13680.400000000001 13814.3 9461.8 10798.4 9892.1 9609.7 6351.1 9817.5 True False 10554.398462255009 10160.284842261903 11822.6768210582 11401.891831527173 8605.981860616466 10689.77790016273 9145.9309328246 9354.819539295204 10777.352834009027 11077.671755548117 0.9527632425982442 0.9171859454287629 1.06725285619128 1.029267889781684 0.7768764096396217 0.9649841714084807 0.8256185175593392 0.8444752422466351 0.9728897074975453 1.0 13.435367075044628 -6.228860065028603 24.994039906850816 0.8894804596763042 0.9917034769176919 0.2653028903138158 0.07605523326063592 835.0403511231746 640622.2222197931 0.02203484671571915 0.028444952897310572 5.903912807888418e-07 6.228860065028603 0.10222301724138771 GGIDNPAITS(ph)DQELDDK ddPTM_A459_Selumetinib_30min_R1 2 GGIDNPAITSDQELDDK 17 0 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GGIDNPAIT(0.226)S(0.774)DQELDDK;GGIDNPAIT(0.026)S(0.974)DQELDDK 276.3 7.795499999999998e-53 17681100.0 8486.9 11002.5 11998.9 11971.2 9292.7 10376.4 10129.5 9190.7 6405.9 9712.9 True False 8684.6282573673 9714.322185076522 10369.51528523985 9880.65464725524 8452.176925759437 10272.022837017385 9365.423659692762 8946.932780399025 10870.34443157538 10959.645326657841 0.7924187324057949 0.8863719486841203 0.9461542756331192 0.9015487593582884 0.7712089829404124 0.9372586913950666 0.8545371114257364 0.81635240135343 0.9918518444328441 1.0 13.419913490461822 -8.278282787276096 23.473175335278476 0.9959260512030502 0.8671544193445792 0.4809450085632597 0.055020050555121124 374.49419695793057 521888.7411324874 0.05257725432476568 0.013757270562135932 5.268866717842224e-09 8.278282787276096 -0.12877163185847107 GGIDNPAITS(ph)DQELDDKK ddPTM_A459_Selumetinib_30min_R1 2 GGIDNPAITSDQELDDKK 18 1 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GGIDNPAIT(0.041)S(0.959)DQELDDKK;GGIDNPAIT(0.313)S(0.687)DQELDDKK 168.83 5.540600000000001e-08 145420000.0 8017.1 9970.1 11141.3 11520.0 7543.6 8343.900000000001 7259.5 7882.5 5096.6 7520.7 True False 8203.882831438968 8802.796057026255 9628.372654780247 9508.248257182267 6861.282711930751 8259.967941655046 6711.910070343022 7673.430494031498 8648.557959063846 8486.055102821563 0.9667487109188374 1.0373248759720377 1.1346111400548025 1.120455634800301 0.808536196005776 0.9733578018965084 0.7909340664204916 0.9042400032825768 1.019149399134617 1.0 13.050878331227256 -6.250989838027331 24.983513474268804 0.9078592119323702 1.0678112245945022 0.4397664583348585 0.08190962800793748 637.1643500462849 1523377.7277717546 0.02443236708648024 0.03120425732219995 5.610611040392472e-07 6.250989838027331 0.159952012662132 GGIDNPAITS(ph)DQELDDKK ddPTM_A459_Selumetinib_30min_R2 3 GGIDNPAITSDQELDDKK 18 1 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GGIDNPAIT(0.088)S(0.912)DQELDDKK;GGIDNPAIT(0.023)S(0.977)DQELDDKK;GGIDNPAIT(0.221)S(0.779)DQELDDKK 179.7 7.755099999999999e-10 181548000.0 760600.0 625410.0 645060.0 585580.0 598060.0 545640.0 637820.0 626120.0 408216.0 565970.0 True False 718328.896923042 673376.9359898951 603557.5418882241 505822.99381815654 522926.35607576295 620796.9571732387 667479.893816354 627941.9055402542 489870.60650803207 549628.9755333393 1.3069341845123843 1.225148174432535 1.0981181283293053 0.9202989950217324 0.9514170092075929 1.1294836786412883 1.2144190418066234 1.1424832632430322 0.8912750752135657 1.0 19.068098537101463 -5.210094789330997 2.7728908508577588 1.047521346850993 1.291252228584283 0.4625057521317114 0.09856261895959498 0.2842704385172438 4.201325165778807 0.029116446247336815 0.09916579673160172 6.164604382132516e-06 5.210094789330997 0.24373088173328994 GGIPAS(ph)PIDPFQSR ddPTM_A459_Selumetinib_30min_R1 4 GGIPASPIDPFQSR 14 0 Q96LD4-2;Q96LD4 Q96LD4-2 TRIM47 Tripartite motif-containing protein 47 1 GGIPAS(1)PIDPFQSR;GGIPAS(1)PIDPFQSR;GGIPAS(1)PIDPFQSR;GGIPAS(1)PIDPFQSR 179.46 7.2649e-05 104491000.0 13379.4 19598.7 12343.199999999999 12762.8 14232.599999999999 13831.699999999999 17920.5 17475.699999999997 8897.6 13588.9 True False 13691.11398821951 17304.075092811552 10667.061236344365 10534.016567427598 12945.263842969624 13692.565656178778 16568.742257122667 17012.18766692625 15098.577345007754 15333.167682095018 0.8929083847564661 1.1285388284782158 0.695685422445396 0.687008502471963 0.8442654584731492 0.8930030597766163 1.0805818210982239 1.1095024863513279 0.9847004649038567 1.0 13.90436815398636 -7.154329061973854 4.09354152149417 1.052575219136685 0.8493408947783944 0.3738261938321521 0.11901881092173111 0.27407522620068536 7.956304380374882 0.05192816173765958 0.03943496230066289 7.009240118148336e-08 7.154329061973854 -0.2032343243582907 GGIPAS(ph)PIDPFQSR ddPTM_A459_Selumetinib_30min_R2 5 GGIPASPIDPFQSR 14 0 Q96LD4-2;Q96LD4 Q96LD4-2 TRIM47 Tripartite motif-containing protein 47 1 GGIPAS(1)PIDPFQSR;GGIPAS(0.999)PIDPFQS(0.001)R;GGIPAS(1)PIDPFQSR;GGIPAS(0.995)PIDPFQS(0.005)R;GGIPAS(0.986)PIDPFQS(0.014)R 173.25 0.00010761 72928400.0 168147.0 125387.0 151411.0 164244.0 182162.0 144128.0 150791.0 175267.0 168956.0 176336.0 True False 158802.0628857726 135003.77971724988 141669.38110383198 141873.68386329632 159277.18101105763 163980.32373628134 157803.080286698 175776.99795298616 202751.92102507327 171244.72150405028 0.9273398998287758 0.7883675393408069 0.827291958896854 0.828485004484887 0.9301143977584758 0.9575788514590967 0.9215062449849916 1.0264666636678124 1.183989318002294 1.0 17.3856999931535 -7.296860744565258 0.8837678611953691 1.0853670026645432 0.841509406245252 0.6603054854146708 0.06375021719050693 0.35731312054465536 0.5388700596595275 0.05055640730973628 0.02874053885782981 5.048231418870625e-08 7.296860744565258 -0.24385759641929128 GGKDPLS(ph)SPGGPGSR ddPTM_A459_Selumetinib_30min_R2 1 GGKDPLSSPGGPGSR 15 1 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 GGKDPLS(0.5)S(0.5)PGGPGSR 128.82 0.0051053 0.0 13977.0 12582.0 15335.0 16126.0 16339.0 12309.0 14021.0 13595.0 12419.0 18131.0 True False 13200.214294364137 13546.998942493507 14348.362795485566 13929.61098109837 14286.348747486698 14004.453020023102 14673.00428208442 13634.559199226587 14903.147015852528 17607.51092000459 0.7496922395411864 0.7693875076404026 0.8149001219237536 0.7911175545699868 0.8113780995163496 0.7953681291835569 0.8333377925334032 0.7743604000117826 0.8464085062085903 1.0 14.103903357022212 -14.522878745278794 0.21413019208834075 1.9960994267854315 0.7712484300525879 0.8867441193514538 0.02242056795966905 45.77967468185867 0.45600101389894776 19.587630716242334 0.045605263885614075 3.0000000000106644e-15 14.522878745278794 -1.2248509967328436 GGKDPLSS(ph)PGGPGSR ddPTM_A459_Selumetinib_30min_R1 1 GGKDPLSSPGGPGSR 15 1 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 GGKDPLS(0.004)S(0.995)PGGPGS(0.001)R 168.47 0.00031265 3149500.0 1166.3 1318.7 1473.8 1268.3 1030.6 1158.1 1341.8 1412.7 841.27 1009.4 True False 1193.4725207752524 1164.3059909530025 1273.666055003916 1046.8152139396068 937.382411967208 1146.4505654706677 1240.5869457106219 1375.2306069036854 1427.5737460702514 1138.9663223886196 1.0478558472846884 1.0222479524339587 1.1182648950785539 0.9190923325496094 0.823011526803836 1.0065710837405204 1.0892217981554408 1.2074374631372564 1.2533941680350738 1.0 10.153509373901933 -7.438216281352024 3.052723624804048 1.1708755490759535 0.9861646021278767 0.3718645080488978 0.09581630087200763 0.2730517541316567 4.921144271841509 0.049123225466726865 0.029738148368620158 3.6457234241618116e-08 7.438216281352024 -0.18471094694807677 GGKDPLSS(ph)PGGPGSR ddPTM_A459_Selumetinib_30min_R2 1 GGKDPLSSPGGPGSR 15 1 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 GGKDPLS(0.04)S(0.959)PGGPGS(0.001)R 122.96 0.007111 3314300.0 17700.0 15659.0 19777.0 19044.0 18863.0 15232.0 16181.0 16458.0 13271.0 17320.0 True False 16716.304858713975 16859.994948379117 18504.56935156948 16450.174347267606 16493.261302640418 17330.069737670954 16933.448562043228 16505.890055231437 15925.570822721562 16819.92659723565 0.9938393465677366 1.0023821953628531 1.100157556847525 0.9780170116777552 0.9805786729979594 1.0303296888655356 1.006749254472147 0.9813294939077899 0.946827605379617 1.0 14.03788378918322 -7.778859465003019 3.4557814939840186 0.9710239931662589 1.014619971203523 0.195245862645387 0.0347855659755739 0.37632252445518405 9.346107731005347 0.020879348058523258 0.009808241419867421 1.663951007472337e-08 7.778859465003019 0.04359597803726423 GGKNS(ph)TWSGESK ddPTM_A459_Selumetinib_30min_R1 1 GGKNSTWSGESK 12 1 P19338 P19338 NCL Nucleolin 1 GGKNS(0.979)T(0.02)WSGESK 122.46 0.01272 0.0 1046.1 1961.1 1627.5 2510.3 1924.0 1542.7 1580.7 1549.4 677.81 1056.2 True False 1070.4720946437374 1731.4935003093433 1406.4944392175828 2071.9232291670705 1749.9745397097893 1527.1818386595282 1461.4665263711283 1508.304878839506 1150.1940647162935 1191.7735582592234 0.8982176917965303 1.4528712172792855 1.1801691936109018 1.73852089166456 1.4683783908294694 1.2814362494249516 1.2262954789044278 1.265596864762319 0.9651112468012267 1.0 10.218894428674945 -8.05607507247427 1.374722877818996 0.9707725278394608 1.3534881060706212 0.2818470086292748 0.20784311717530138 0.5496247420126517 1.8733888947965534 0.19080240367350942 0.06309947003247202 8.788705814626475e-09 8.05607507247427 0.3827155782311604 GGLHDFRS(ph)PPPGMGLNQNR ddPTM_A459_Selumetinib_30min_R2 1 GGLHDFRSPPPGMGLNQNR 19 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 GGLHDFRS(1)PPPGMGLNQNR 93.062 0.00090478 3335600.0 9369.4 8705.3 9993.9 11375.0 12682.0 8072.0 7921.9 8190.1 5884.1 11189.0 True False 8848.686256679926 9372.968518048705 9350.903354535589 9825.705377030508 11088.773781481515 9183.844729679626 8290.284046947052 8213.931835055955 7061.084415490611 10865.944497486691 0.8143504008074623 0.8626004412425157 0.8605697697699879 0.9042661113631869 1.0205071251787055 0.8451952549365462 0.7629602791422878 0.7559335349960465 0.6498362307228653 1.0 13.407525962500957 -7.086662091398446 4.797901169899011 0.7734787075381914 0.8933166932859993 0.18349458113212813 0.09584852509476173 0.32093848821232207 12.659857693534162 0.03663249037961958 0.028434602302289766 8.191018533623282e-08 7.086662091398446 0.1198379857478079 GGLLTSEEDSGFS(ph)TSPKDNSLPK ddPTM_A459_Selumetinib_30min_R2 1 GGLLTSEEDSGFSTSPKDNSLPK 23 1 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 GGLLTS(0.002)EEDS(0.02)GFS(0.324)T(0.324)S(0.324)PKDNS(0.005)LPK 57.798 0.0084286 4230700.0 26141.0 31192.0 24656.0 24638.0 21969.0 14412.0 14289.0 16050.0 11963.0 21564.0 True False 24688.187870714228 33584.32610191206 23069.65980342305 21282.261897079363 19209.057814648117 16397.122180889837 14953.466813116356 16096.702842779463 14355.934274147994 20941.391289999385 1.178918226054261 1.6037294579348385 1.101629757256865 1.0162773620128458 0.9172770590376892 0.783000611268857 0.7140627194267376 0.7686548911612422 0.6855291549326862 1.0 14.35406967380023 -5.831618340228787 1.236778599036691 0.7771397691405022 1.400551747160686 0.7256180595006073 0.13758158203695553 0.2271617568740827 0.694894512847347 0.046953169684923586 0.11060950492953792 1.4736069453936118e-06 5.831618340228787 0.6234119780201839 GGLLTSEEDSGFST(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 GGLLTSEEDSGFSTSPK 17 0 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 GGLLTSEEDSGFST(0.854)S(0.146)PK;GGLLTSEEDSGFS(0.001)T(0.989)S(0.009)PK 272.74 1.9017e-51 40466000.0 7387.9 9693.9 7548.0 6460.700000000001 5941.200000000001 5797.8 7151.9 8286.2 5404.8 8451.400000000001 True False 7560.02369564905 8558.933681428152 6523.023058196201 5332.460027359162 5403.819509004056 5739.479395981209 6612.426424972279 8066.423058629092 9171.550849026466 9536.219513607273 0.7927694706336844 0.8975185259961111 0.6840261016316237 0.5591796644100161 0.5666626592742882 0.6018610821396803 0.6934012388805626 0.8458722082811829 0.9617596193061139 1.0 13.219201730146269 -7.992798509630834 2.2355885953477697 0.9858436797663298 0.6792943103948056 0.6042803808010959 0.09716698745674963 0.25707927342736486 2.387874498833583 0.09285255591420227 0.03181786912824059 1.0167202895412616e-08 7.992798509630834 -0.3065493693715242 GGLLTSEEDSGFST(ph)SPK ddPTM_A459_Selumetinib_30min_R2 3 GGLLTSEEDSGFSTSPK 17 0 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 GGLLTSEEDSGFS(0.008)T(0.807)S(0.185)PK;GGLLTSEEDSGFS(0.007)T(0.852)S(0.141)PK;GGLLTSEEDSGFS(0.079)T(0.556)S(0.365)PK 214.89 1.5203e-09 35883000.0 170766.3 134013.0 135141.5 135908.3 123793.1 106484.8 161739.0 163544.3 117851.8 111592.5 True False 161275.7926776614 144291.36618028802 126446.64302093965 117397.35508510548 108241.10405364443 121152.11462722857 169260.18397974857 164020.1868367838 141425.4530544203 108370.53457286493 1.488188586623836 1.331463084029276 1.166799107518667 1.0832958935546377 0.9988056668749431 1.1179433146172193 1.5618653598681234 1.513512759563826 1.305017582609877 1.0 16.725613022603106 -7.241374112029143 24.914952154919714 1.3878916818315181 1.1881750299665925 0.10778224735699415 0.19135438754641523 1340.742062951861 1664795.6815171165 0.07601358815340582 0.05879397877016601 5.7362211701053514e-08 7.241374112029143 -0.1997166518649256 GGLLTSEEDSGFST(ph)SPKDNSLPK ddPTM_A459_Selumetinib_30min_R2 1 GGLLTSEEDSGFSTSPKDNSLPK 23 1 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 GGLLTS(0.001)EEDS(0.003)GFS(0.033)T(0.482)S(0.482)PKDNSLPK 91.067 0.00021493 5331000.0 44377.0 55930.0 44804.0 43472.0 45167.0 27333.0 29022.0 22953.0 16386.0 41660.0 True False 41910.70399520624 60219.651156705026 41921.3594189068 37551.03860661715 39492.7176618968 31097.872645730055 30371.580506002003 23019.7894299263 19663.65786309361 40457.167554320855 1.0359277855755413 1.4884791693795558 1.036191161000582 0.9281677605383096 0.9761612107142916 0.768661637124638 0.7507095118614723 0.5689916230299165 0.4860364442639662 1.0 15.304107698497143 -6.186946022342954 0.8223605307581247 0.6615001123369812 1.2698917726363572 0.5675441447093961 0.17648584336001819 0.4530779074618243 0.6488512250735002 0.09051490726903935 0.1683214040285519 6.502104987802296e-07 6.186946022342954 0.608391660299376 GGLLTSEEDSGFSTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 GGLLTSEEDSGFSTSPK 17 0 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 GGLLTSEEDSGFS(0.001)T(0.298)S(0.701)PK 208.39 4.7056e-09 5638800.0 1381.6 1689.4 1190.2 1456.6 993.11 1021.2 1434.1 1308.1 933.23 1291.2 True False 1413.7885918743796 1491.6042626192468 1028.577377300625 1202.232153768376 903.2833758478112 1010.9276551754127 1325.9246823994663 1273.4049386923696 1583.6231495775917 1456.9380973530665 0.9703834325170849 1.0237938491203993 0.7059856415103167 0.8251772370786139 0.6199874774974151 0.693871384798053 0.9100761966540497 0.8740281697663504 1.0869529408659735 1.0 10.508723865881286 -7.995902084519271 2.0289541369519526 1.0399357934718245 0.8089469726617651 0.3359330273234167 0.12134864288188803 0.4278905699694365 3.226822123170087 0.11112139341139496 0.03742355981300304 1.0094804565998105e-08 7.995902084519271 -0.23098882081005945 GGLLTSEEDSGFSTS(ph)PKDNSLPK ddPTM_A459_Selumetinib_30min_R1 2 GGLLTSEEDSGFSTSPKDNSLPK 23 1 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 GGLLTSEEDS(0.004)GFS(0.021)T(0.211)S(0.763)PKDNS(0.001)LPK;GGLLTSEEDSGFS(0.009)T(0.44)S(0.524)PKDNS(0.027)LPK 115.11 5.9787e-06 67359000.0 3736.0 3567.5 6286.200000000001 6556.1 3526.8999999999996 3636.4 3540.3 3908.1 2907.6 3360.6 True False 3823.041531009465 3149.8154415142467 5432.568567624927 5411.200208238953 3207.892517724768 3599.821117587029 3273.252320688119 3804.4444927021227 4933.984837298205 3791.9657450160457 1.008195165273912 0.8306550357566371 1.4326523320431364 1.4270171652661001 0.8459708587666036 0.949328490722375 0.8632072494300099 1.0032908387166941 1.3011680930354308 1.0 11.888730216272021 -6.288440490242792 24.983838371032434 0.9852361766481987 1.1684905816495181 0.15882288994553617 0.20307071306398894 1522.3168669397432 1408578.685860591 0.06834008311623847 0.07750776925223161 5.147063304755057e-07 6.288440490242792 0.1832544050013194 GGLNTPLHESDFSGVT(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 GGLNTPLHESDFSGVTPQR 19 0 Q99459 Q99459 CDC5L Cell division cycle 5-like protein 1 GGLNTPLHES(0.005)DFS(0.278)GVT(0.717)PQR 70.15 0.022284 2740200.0 14015.0 12265.0 18768.0 26017.0 30462.0 20080.0 16387.0 17010.0 15415.0 25840.0 True False 13236.10240649019 13205.68606180917 17560.487313053363 22473.43971817166 26635.091226264754 22845.837731908665 17149.027970224473 17059.496283842913 18498.430731086795 25093.932059617156 0.5274622715580958 0.526250171971281 0.6997901831938439 0.895572669312253 1.061415610873026 0.9104128311829506 0.6833934167623671 0.6798255547721117 0.7371674828456125 1.0 14.61505092915042 -5.463543708597373 3.1029114135242275 0.8424056855573546 0.5272484437646219 0.5390559977634861 0.1201415930546088 0.22620515664188284 4.255732031853497 0.03770042108489788 0.08547927950374476 3.4391909667007064e-06 5.463543708597373 -0.31515724179273275 GGLS(ph)PANDTGAK ddPTM_A459_Selumetinib_30min_R1 4 GGLSPANDTGAK 12 0 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 GGLS(1)PANDTGAK;GGLS(1)PANDTGAK;GGLS(1)PANDTGAK;GGLS(1)PANDTGAK 195.94 0.00010345 2453546000.0 27979.6 35139.3 30705.2 32628.0 30849.7 27539.699999999997 32055.0 28629.300000000003 15753.2 24519.0 True False 28631.470241175728 31025.174420182633 26535.602491590613 26930.13230341521 28059.35008195689 27262.67562204692 29637.065542371427 27869.957962927492 26732.029831794658 27666.252485284884 1.0348879110535198 1.1214086344612193 0.9591325209550646 0.9733928481184358 1.014208559575645 0.9854126660828887 1.071235273303993 1.0073629588160145 0.966232410624203 1.0 14.755839617387918 -5.262770413450831 24.999994682960608 0.9993765722009054 1.0781482725640068 0.4501928165578163 0.035747751153266706 101.88081921536423 1913597.6037973983 0.00939990665629817 0.021495364782191908 5.4604644820018645e-06 5.262770413450831 0.07877170036310144 GGLS(ph)PANDTGAK ddPTM_A459_Selumetinib_30min_R2 7 GGLSPANDTGAK 12 0 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 GGLS(0.981)PANDT(0.019)GAK;GGLS(1)PANDTGAK;GGLS(1)PANDTGAK;GGLS(1)PANDTGAK;GGLS(0.998)PANDT(0.002)GAK;GGLS(1)PANDTGAK;GGLS(0.994)PANDT(0.006)GAK 171.26 0.00027317 2917527800.0 3380799.0 3172808.0 3493596.0 3678397.0 3665394.0 2754611.0 3112323.0 3297712.0 2406138.0 3368895.0 True False 3192907.7259906954 3416152.171414322 3268821.836899717 3177392.983011248 3204914.4366818857 3134033.661381011 3257052.186451023 3307307.795954393 2887432.8331129225 3271626.2479095994 0.9759390236066234 1.0441755605784944 0.9991428082557797 0.9711968123013558 0.9796089754230517 0.9579436720143375 0.995545315890564 1.0109063644013714 0.882568060748945 1.0 21.641576512870955 -5.648158050175113 4.187805965342565 0.972389931559473 1.0124974716600512 0.164179123548147 0.0367134881292461 0.36362039724030676 11.358925127929604 0.00976728331988461 0.017547174846471184 2.248236269853847e-06 5.648158050175113 0.040107540100578265 GGLS(ph)PANDTGAKK ddPTM_A459_Selumetinib_30min_R1 3 GGLSPANDTGAKK 13 1 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 GGLS(1)PANDTGAKK;GGLS(1)PANDTGAKK;GGLS(1)PANDTGAKK 167.37 0.00055253 51187800.0 6180.3 6103.4 10832.300000000001 11956.5 8383.9 7858.6 7371.3 7343.6 4015.8 5652.3 True False 6324.288965229607 5388.811090606322 9361.333157564748 9868.521726302068 7625.577725297766 7779.549619037895 6815.276906332327 7148.823872625397 6814.519297572619 6377.827763064391 0.9916054807649651 0.8449289147967097 1.467793346784714 1.547317063570322 1.1956387046792656 1.2197804500289628 1.0685890493627492 1.1208869443019516 1.0684702614638197 1.0 12.638849421962503 -7.259462936473391 20.876869670014553 1.074560441693592 1.2207668544974042 0.12053080480398026 0.19231140697608745 46.65846558917668 492876.25689192384 0.08559107687766057 0.06276175540512799 5.50220875415133e-08 7.259462936473391 0.14620641280381208 GGLTS(ph)PIFCSTKPK ddPTM_A459_Selumetinib_30min_R1 1 GGLTSPIFCSTKPK 14 1 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 GGLT(0.06)S(0.904)PIFCST(0.036)KPK 78.244 0.021172 17393000.0 1346.3 1570.3 1637.5 2232.3 1606.9 1453.6 1355.1 1405.9 900.21 1353.8 True False 1377.6661705562212 1386.448545987336 1415.136494143651 1842.470710460764 1461.556178721238 1438.9781037632 1252.8837160027313 1368.610964993197 1527.590621262973 1527.5734171287038 0.9018657663902957 0.9076149993454112 0.9263950774972279 1.2061421662625913 0.9567829358201619 0.9420025824146432 0.8201790512679307 0.895937929821861 1.0000112623943807 1.0 10.577026004137952 -6.753090631957947 4.026094889889061 0.9168993389827629 0.9864945833672244 0.053836603685958107 0.09472937789271535 0.5593820445704067 20.315638064031155 0.03559033201565413 0.033466406588545154 1.765669308600244e-07 6.753090631957947 0.06959524438446152 GGLTS(ph)PIFCSTKPK ddPTM_A459_Selumetinib_30min_R2 2 GGLTSPIFCSTKPK 14 1 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 GGLT(0.123)S(0.863)PIFCS(0.007)T(0.007)KPK;GGLT(0.147)S(0.853)PIFCSTKPK 77.068 0.022506 30370000.0 129072.0 122627.0 143987.0 150682.0 152379.0 122839.0 136195.0 138845.0 111091.0 156407.0 True False 121898.69495615437 132032.09659204824 134723.0331811924 130158.85165905146 133235.78773445587 139758.9572285823 142528.33736527275 139249.0159629728 133312.30414188528 151891.12351581024 0.8025399518719475 0.8692548552931411 0.8869710754833491 0.8569220415668551 0.877179552369217 0.9201259033022748 0.938358569389587 0.9167686217587196 0.8776833106248563 1.0 17.212678035956166 -1.522878745480796 0.058106347286735895 1.14714262734622 0.3794343537227353 0.724872641883449 0.026410223557922042 205.57156874699677 0.8977040651685982 2.476196939776349 13.488984598036907 0.029999999986152825 1.522878745480796 -0.7677082736234846 GGLVS(ph)DAYGEDDFSR ddPTM_A459_Selumetinib_30min_R1 2 GGLVSDAYGEDDFSR 15 0 J3KS14;F5H478;J3KRU5;X6R3T8;J3QLH3;J3QQJ0;Q9UHR5-2;Q9UHR5 J3KS14 SAP30BP SAP30-binding protein 1 GGLVS(1)DAYGEDDFSR;GGLVS(1)DAYGEDDFSR 302.35 9.753899999999996e-81 25300000.0 2443.9300000000003 2964.5 2898.94 2867.2 2519.9700000000003 2484.0299999999997 2807.6 2460.66 1559.22 2170.79 True False 2500.868813940033 2617.4149618413385 2505.2798707375837 2366.4973440098106 2292.0391584368394 2459.0429135187833 2595.820471588272 2395.3953034498627 2645.8824590769386 2449.4320417852114 1.0209994689696853 1.068580355441785 1.0228003177878202 0.9661412538251293 0.9357431107851191 1.0039237143834239 1.0597642340370337 0.977939074277821 1.0802024362956193 1.0 11.25823155001646 -10.273399704831526 14.15142832629768 1.0000046305138708 1.0130345281749968 0.008502488398513197 0.04407605173067679 0.0 0.0 0.044891132381501136 0.010887698850736148 5.328442641889616e-11 10.273399704831526 0.013029897661126055 GGLVS(ph)DAYGEDDFSR ddPTM_A459_Selumetinib_30min_R2 2 GGLVSDAYGEDDFSR 15 0 J3KS14;F5H478;J3KRU5;X6R3T8;J3QLH3;J3QQJ0;Q9UHR5-2;Q9UHR5 J3KS14 SAP30BP SAP30-binding protein 1 GGLVS(1)DAYGEDDFSR;GGLVS(1)DAYGEDDFSR 241.27 3.5037000000000005e-20 13053500.0 37317.0 40271.0 45949.0 51510.0 47201.0 43887.0 48510.0 49192.0 41135.0 39238.0 True False 35243.07053178696 43359.65620832587 42992.691365488514 44494.249140293745 41271.188397706115 49932.03588347989 50765.8111207414 49335.14057582599 49363.149407930934 38105.09698743257 0.9248912433790804 1.1378964924987938 1.1282661576656772 1.1676718512215933 1.0830883965816371 1.310376821766074 1.3322577590468923 1.2947123738353745 1.2954474154523574 1.0 15.217696366944436 -6.756289724344609 24.996712940864494 1.2703345850878078 1.0977375828407983 0.33584154616789685 0.10829108321063924 133.69762892279834 648976.025559852 0.034793700958188734 0.033797170843279635 1.7527108521150296e-07 6.756289724344609 -0.17259700224700958 GGMGS(ph)GGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R1 1 GGMGSGGLATGIAGGLAGMGGIQNEK 26 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 GGMGS(1)GGLATGIAGGLAGMGGIQNEK 116.52 5.1462e-09 13490000.0 2998.4 4135.5 3385.6 4218.0 3815.3 3274.9 4066.3 4022.8 1623.0 3586.2 True False 3068.2568861292257 3651.31373745821 2925.8541157696127 3481.4054816662197 3470.206788645926 3241.95747937129 3759.57571720309 3916.102276104015 2754.1124607700476 4046.5237025461333 0.7582451288246829 0.9023334609805322 0.7230537446076546 0.8603447644395774 0.8575772795949322 0.8011710094102258 0.9290877784399257 0.9677695137779484 0.6806119680053075 1.0 11.982467330750268 -6.738167768844813 1.1460922548969878 0.8863050173688183 0.8105030152964233 0.11500316148880485 0.09458998991108925 1.1831667147733063 3.2976145635988376 0.047315471889317 0.043670769545092226 1.8273941536833104e-07 6.738167768844813 -0.07580200207239496 GGMGS(ph)GGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R2 2 GGMGSGGLATGIAGGLAGMGGIQNEK 26 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 GGMGS(1)GGLATGIAGGLAGMGGIQNEK;GGMGS(0.997)GGLAT(0.003)GIAGGLAGMGGIQNEK 197.61 3.8647999999999995e-32 11146400.0 59395.0 62052.0 66335.0 73766.0 79993.0 52654.0 56562.0 67359.0 56521.0 62024.0 True False 56094.06367702354 66811.1888713724 62067.07832008701 63718.94354655231 69943.56419350662 59906.61055457768 59192.245075476705 67555.00353811734 67826.77932869 60233.20596229465 0.9312813884112002 1.1092085802836977 1.0304462020324858 1.0578706965463485 1.1612127077760157 0.9945778179577323 0.9827178236624234 1.1215574940574482 1.126069553248566 1.0 15.87827142915292 -4.749694886709228 24.90875451008012 1.0656051662909358 0.9312810745862888 0.31231652847958935 0.05945071909459619 653.6382416198167 1386203.330034553 0.015023022682944394 0.23664419489639305 1.7795291779807372e-05 4.749694886709228 -0.134324091704647 GGNFGFGDSR ddPTM_A459_Selumetinib_30min_R1 2 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 154.01 0.0079451 36343000.0 8717.1 10734.5 10527.2 11886.599999999999 11069.5 9509.8 10451.8 9879.3 5303.9 8491.2 False True 8920.191469476074 9477.699749666335 9097.664061770402 9810.828449116567 10068.265679478962 9414.140046207547 9663.41231120754 9617.268871510993 9000.330918470883 9581.1282312921 0.9310168128574465 0.9892049788783783 0.9495399541838198 1.023974234795675 1.0508434326758997 0.9825711355642682 1.0085881409714046 1.0037720651833943 0.9393811147496884 1.0 13.22597983601512 -4.32799259290665 1.036778956251077 0.9998887960938379 0.8309840591607741 0.28055112279882666 0.030794487025368352 5.589853355135918 2.570948902340985 0.010045567852988276 1.3093610483469749 4.699021229350156e-05 4.32799259290665 -0.16890473693306374 GGNFGFGDSR ddPTM_A459_Selumetinib_30min_R2 1 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 131.12 0.036901 55626000.0 79646.0 78171.0 91227.0 91159.0 95768.0 68562.0 73018.0 78988.0 56213.0 78973.0 False True 75219.59416819966 84166.46434061836 85357.5541404473 78742.98694195373 83736.76766321734 78005.79315613155 76413.48168242212 79217.84200283264 67457.17072245097 76692.84429350417 0.9807902531340947 1.0974487270091664 1.1129793780210213 1.0267318635439266 1.0918459008086336 1.017119574514706 0.9963573836170044 1.0329235110861879 0.879575811066438 1.0 16.226804355141155 -7.472142713094891 1.1230013466397712 0.956208323858996 1.0645762985264802 0.39353228260710726 0.05053746780818458 0.5014194579265115 1.1853070397980061 0.0374946088501889 0.017980212938036838 3.371764912073287e-08 7.472142713094891 0.10836797466748416 GGNLPPVS(ph)PNDSGAK ddPTM_A459_Selumetinib_30min_R1 3 GGNLPPVSPNDSGAK 15 0 Q9UK61-3;Q9UK61;Q9UK61-2;A0A087X0F1;Q9UK61-4 Q9UK61-3 FAM208A Protein FAM208A 1 GGNLPPVS(1)PNDSGAK;GGNLPPVS(1)PNDSGAK;GGNLPPVS(1)PNDSGAK 161.94 0.00011605 45453000.0 13971.6 16699.6 17943.800000000003 19373.600000000002 16394.0 14004.8 16410.7 15950.2 8666.36 13313.2 True False 14297.111095998887 14744.403068566591 15507.130518238064 15990.36444751272 14911.165594595785 13863.924427340995 15172.82768666964 15527.148882448613 14706.179954109131 15022.07890154961 0.9517398483723888 0.9815154856526299 1.032289247038798 1.0644574930213704 0.9926166472909163 0.922903182588853 1.0100351480050127 1.0336218431689173 0.9789710232844075 1.0 13.874796860405352 GGNLPPVS(ph)PNDSGAK ddPTM_A459_Selumetinib_30min_R2 5 GGNLPPVSPNDSGAK 15 0 Q9UK61-3;Q9UK61;Q9UK61-2;A0A087X0F1;Q9UK61-4 Q9UK61-3 FAM208A Protein FAM208A 1 GGNLPPVS(1)PNDSGAK;GGNLPPVS(1)PNDSGAK;GGNLPPVS(0.998)PNDS(0.002)GAK;GGNLPPVS(1)PNDSGAK;GGNLPPVS(1)PNDSGAK 151.73 0.00024075 69768000.0 407876.0 391798.0 401765.0 439204.0 435655.0 329909.0 367585.0 375242.0 302074.0 393952.0 True False 385207.8847769954 421847.64677086927 375915.87730865757 379383.6575308408 380924.12409488467 375350.97013427626 384678.4308558589 376333.89209534315 362497.24065276084 382577.5821497788 1.0068752136819843 1.1026460160065423 0.9825873099942558 0.9916515635835463 0.9956781104485971 0.9811107279864786 1.0054913011219189 0.9836799374930671 0.947513021060506 1.0 18.54539281317861 -5.288342621854945 24.720967873489833 0.9864552630196161 1.0547606180536393 0.5263926788050637 0.026099125414607963 396.54573706513787 364379.01392273896 0.00638302735655993 0.01329196255228638 5.148223327669062e-06 5.288342621854945 0.06830535503402324 GGNVFAALIQDQS(ph)EEEEEEEKHPPKPAKPEK ddPTM_A459_Selumetinib_30min_R1 2 GGNVFAALIQDQSEEEEEEEKHPPKPAKPEK 31 3 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 GGNVFAALIQDQS(1)EEEEEEEKHPPKPAKPEK;GGNVFAALIQDQS(1)EEEEEEEKHPPKPAKPEK 51.539 0.006873000000000001 78679200.0 2383.9900000000002 3797.9 4053.46 4321.01 3136.03 3455.04 3019.09 2837.52 1723.8500000000001 2979.27 True False 2439.53232856297 3353.2401024041906 3503.0223960619965 3566.4267189034013 2852.3766402110673 3420.285434525321 2791.3576106166956 2762.2597520360623 2925.2475449774765 3361.688325047299 0.7256866469108632 0.9974869107941501 1.0420425861498357 1.0609034431689088 0.8484952691653633 1.0174308572991215 0.8303439643166269 0.8216882366681622 0.8701721462938771 1.0 11.714970257673865 -7.272030581006245 24.782343018865976 0.8656917734651025 0.9556847897086019 0.08321876953062124 0.10474823408230663 1330.7017510233788 3113694.765605951 0.043483203956520784 0.029665970378585295 5.3452671917553324e-08 7.272030581006245 0.08999301624349942 GGPAS(ph)PGGLQGLETR ddPTM_A459_Selumetinib_30min_R1 4 GGPASPGGLQGLETR 15 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 GGPAS(0.986)PGGLQGLET(0.014)R;GGPAS(1)PGGLQGLETR;GGPAS(1)PGGLQGLETR;GGPAS(1)PGGLQGLETR 201.4 1.5912e-05 342921000.0 10257.6 11860.099999999999 12328.4 13238.9 11825.6 10048.599999999999 11414.199999999999 9439.3 6172.5 8579.0 True False 10496.582122184882 10471.5139783891 10654.270995053796 10926.974639931459 10755.976567979249 9947.520207398802 10553.217704374856 9188.939100832411 10474.281678436913 9680.198216536526 1.0843354534056688 1.081745822156904 1.100625292657053 1.1287965799362543 1.1111318515776865 1.0276153426699066 1.0901861168862188 0.9492511305331636 1.082031735728703 1.0 13.24082087380312 -7.111328937715717 1.4704745885017063 1.0183651840135208 1.1007640778134655 0.4224651219277338 0.04025848043420806 0.3812625509515 1.641916787411975 0.020823949003925587 0.01401813166055893 7.738754370380344e-08 7.111328937715717 0.0823988937999447 GGPAS(ph)PGGLQGLETR ddPTM_A459_Selumetinib_30min_R2 4 GGPASPGGLQGLETR 15 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 GGPAS(1)PGGLQGLETR;GGPAS(1)PGGLQGLETR;GGPAS(1)PGGLQGLETR;GGPAS(1)PGGLQGLETR 200.81 1.7756e-05 351772000.0 123178.0 127423.0 137665.0 135499.0 137071.0 106506.0 110353.0 113174.0 102652.0 131873.0 True False 116332.2598806027 137195.9343704778 128807.78377831915 117043.8024511876 119850.91554971247 121176.23473479418 115484.63316032107 113503.3176030358 123185.2683365241 128065.4838427978 0.9083810593602426 1.07129517067134 1.0057962529266085 0.9139371432419725 0.935856500544918 0.9462052623292294 0.9017623616842779 0.8862912487986438 0.961892811709795 1.0 16.966522167924637 -5.755411400245685 24.89683218476977 0.9294979714111768 1.002771284828035 0.23896702030120387 0.047782780452389866 157.0932486197036 648819.21044589 0.01250615376642398 0.020957635957301633 1.756259149402543e-06 5.755411400245685 0.07327331341685817 GGPASVPS(ph)SSPGTSVK ddPTM_A459_Selumetinib_30min_R2 2 GGPASVPSSSPGTSVK 16 0 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 GGPASVPS(0.613)S(0.236)S(0.145)PGT(0.006)S(0.001)VK;GGPASVPS(0.52)S(0.299)S(0.174)PGT(0.007)SVK 219.41 9.6934e-11 73799500.0 195208.0 168151.0 188341.0 212088.0 219524.0 148388.0 173949.0 181178.0 138429.0 178880.0 True False 184359.12083953887 181047.64100931693 176223.3451101757 183201.24852779307 191945.43255053996 168827.10006785174 182037.97317340432 181705.1979843673 166118.66802942657 173715.26961394429 1.0612718228469433 1.0422091357407308 1.0144378528255187 1.0546064772252315 1.104942777782917 0.9718610254760232 1.0479100287381529 1.0459943929406978 0.9562698109302653 1.0 17.406365047299687 -8.251155154428865 24.475100948193518 0.9781349054875847 1.0421889306868777 0.37508578756789956 0.033430394464406106 481.0448666943189 1144832.2145326 0.02292908115184814 0.008440701791930738 5.608475739220347e-09 8.251155154428865 0.06405402519929293 GGPASVPSS(ph)SPGTSVK ddPTM_A459_Selumetinib_30min_R1 2 GGPASVPSSSPGTSVK 16 0 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 GGPASVPS(0.095)S(0.705)S(0.196)PGT(0.004)SVK;GGPASVPS(0.247)S(0.522)S(0.174)PGT(0.045)S(0.012)VK 269.87 1.8839999999999996e-50 58469000.0 12022.2 13712.5 15131.5 15676.3 13741.6 10373.0 12708.099999999999 12637.8 6473.0 10955.6 True False 12302.293868870995 12107.034125231692 13076.72541137994 12938.728485596048 12498.674706276535 10268.657037930438 11749.517785649998 12302.604490640177 10984.208230785278 12361.857976580903 0.9951816217414283 0.9793862822375111 1.057828478223365 1.046665356462435 1.0110676509918515 0.8306726268319893 0.9504653594879539 0.9952067491753279 0.8885564169718231 1.0 13.59360797490754 -6.55926754813095 24.99996683114927 0.9323397062982315 1.020758414335756 0.41540622492235035 0.05052036828934086 170.32477001723439 117016.04595547284 0.016720600349597478 0.016720652744661144 2.7588777195182017e-07 6.55926754813095 0.0884187080375245 GGPASVPSS(ph)SPGTSVK ddPTM_A459_Selumetinib_30min_R2 2 GGPASVPSSSPGTSVK 16 0 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 GGPASVPS(0.293)S(0.566)S(0.111)PGT(0.029)SVK;GGPASVPS(0.073)S(0.455)S(0.455)PGT(0.013)S(0.003)VK 219.41 1.7448e-39 4848200.0 61440.0 60875.0 61881.0 69549.0 73517.0 46894.0 55163.0 58614.0 44422.0 60402.0 True False 58025.41076380712 65543.91675602387 57899.64383093856 60076.30622128306 64281.13720968109 53353.22283865165 57728.18880341082 58784.557035929945 53307.64125438454 58658.03731675675 0.9892150064698992 1.1173902120536863 0.9870709365585688 1.0241785946036275 1.0958623941431807 0.909563723561721 0.9841479777387591 1.0021569033837594 0.9087866504383745 1.0 15.840041179237007 -6.761501294099461 24.999999999999016 0.9625169188554071 1.0427661732438955 0.41225373732065085 0.04882453722783527 1.7112776126879001 690652.8120452587 0.016055818079106877 0.015075427957602684 1.731803870358058e-07 6.761501294099461 0.0802492543884884 GGPASVPSSS(ph)PGTSVK ddPTM_A459_Selumetinib_30min_R2 2 GGPASVPSSSPGTSVK 16 0 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 GGPASVPS(0.043)S(0.301)S(0.643)PGT(0.013)SVK;GGPASVPS(0.22)S(0.169)S(0.391)PGT(0.169)S(0.051)VK 256.35 2.5021999999999998e-31 74507700.0 145000.0 133232.0 141280.0 152751.0 158974.0 117711.0 135430.0 131688.0 100768.0 138548.0 True False 136941.48048099034 143450.4659915988 132190.19861403343 131946.0502898274 139002.26487440805 133924.6217759315 141727.7633494539 132071.1902778779 120924.41569316611 134547.75924906498 1.017790866568757 1.0661676329076113 0.9824778900206922 0.980663305180568 1.0331072449679166 0.9953686521677408 1.0533639812395375 0.9815933837545177 0.8987471539330482 1.0 17.037758839051854 -7.999879205503269 24.994742516469493 0.9463058030330969 1.0171271772292523 0.3915437325006913 0.03481721941846925 3.6710307568075113 759678.5487658654 0.018683697022359374 0.008833647256636388 1.0002781782918965e-08 7.999879205503269 0.07082137419615542 GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 3 GGPEGVAAQAVASAASAGPADAEMEEIFDDASPGK 35 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(1)PGK;GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(1)PGK;GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(1)PGK 201.31 4.1506999999999984e-57 58160000.0 8043.599999999999 11609.1 6354.9 7344.4 6722.74 7714.79 8120.3 8217.41 4397.870000000001 8686.4 True False 8231.000229878944 10249.90117507583 5491.939484967016 6061.8384114626315 6114.669353996151 7637.186217068869 7507.779233308964 7999.457592890503 7462.864182283897 9801.384052701114 0.8397793807100747 1.0457605905414054 0.5603228539395434 0.6184675938488585 0.6238577451019317 0.7791946704673994 0.765991740854184 0.8161559173559751 0.7614092195711119 1.0 13.25876977113279 -9.323318069075757 0.7646335870272081 1.0045876642747467 0.7452063992577158 0.24086127502636 0.13016063626137733 5.399372018147911 3.9033614120301126 0.210271963530268 0.04934514128639635 4.749872268508116e-10 9.323318069075757 -0.25938126501703085 GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 3 GGPEGVAAQAVASAASAGPADAEMEEIFDDASPGK 35 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(1)PGK;GGPEGVAAQAVASAAS(0.007)AGPADAEMEEIFDDAS(0.993)PGK;GGPEGVAAQAVASAAS(0.002)AGPADAEMEEIFDDAS(0.998)PGK 113.83 1.7679000000000006e-15 16128000.0 129990.0 94937.59999999999 123211.0 104271.2 106278.6 104114.5 133012.4 139511.4 100160.3 104295.0 True False 122765.67619119954 102219.0086475021 115283.73840199364 90069.28268214707 92926.93212526113 118455.32731766962 139197.74015907035 139917.35507664437 120195.15871260905 101283.73235904705 1.2120966845494971 1.0092342202115887 1.1382256135004691 0.8892768916024424 0.9174911899557435 1.169539515958495 1.3743346233096896 1.3814395640619026 1.1867173129690927 1.0 16.628042949369743 -6.979152477002547 7.390516367437087 1.2682844838799223 1.0305187110399123 0.32928928021065795 0.1343344717564008 0.1683254465775135 40.36588839527898 0.047853706247482426 0.041486419335811514 1.0491740081432834e-07 6.979152477002547 -0.23776577284001 GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(ph)PGKQK ddPTM_A459_Selumetinib_30min_R1 1 GGPEGVAAQAVASAASAGPADAEMEEIFDDASPGKQK 37 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 GGPEGVAAQAVAS(0.05)AAS(0.014)AGPADAEMEEIFDDAS(0.937)PGKQK 54.99800000000001 0.00019343 1800400.0 169.18 223.66 295.39 263.13 203.13 220.51 181.74 201.0 0.0 260.7 True False 173.12156483302502 197.47378322328697 255.27766046112532 217.17928506183785 184.7569273655143 218.29186960706068 168.0312054802866 195.6688270599848 0.0 294.16338443304267 0.5885218011299801 0.6713064700553711 0.8678090951160902 0.738294759153725 0.6280758828010037 0.7420769584487432 0.571217270307596 0.6651705732754882 0.0 1.0 8.200473870139064 -7.682687164274989 2.2122431728341625 0.4855043547143764 0.7064867194752428 0.06678407057022473 0.24049908737615514 0.6493374572210044 6.335989949445642 0.14535081461764388 0.06622749528526575 2.076408680169853e-08 7.682687164274989 0.22098236476086636 GGPEGVAAQAVASAASAGPADAEMEEIFDDAS(ph)PGKQK ddPTM_A459_Selumetinib_30min_R2 1 GGPEGVAAQAVASAASAGPADAEMEEIFDDASPGKQK 37 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 GGPEGVAAQAVAS(0.039)AAS(0.12)AGPADAEMEEIFDDAS(0.841)PGKQK 66.43 1.5648e-05 1244400.0 15255.0 13819.0 12815.0 13978.0 11148.0 10083.0 6395.3 7688.2 5165.0 15787.0 True False 14407.188170603476 14878.872864911604 11990.496851917027 12074.17228660505 9747.488575615509 11471.841725639202 6692.694122046539 7710.571389149973 6198.144322157849 15331.188290447984 0.9397306912980645 0.9704970406098141 0.7820983360688123 0.7875561931574344 0.6357947206015746 0.7482682691195354 0.4365411209655801 0.5029337089254852 0.40428336047634156 1.0 13.90418190135352 -5.918773638876529 0.854456524656693 0.5651596836079772 0.9787010398452852 0.3765759350438348 0.16427611741583784 0.6809747698269213 0.9689364328384993 0.07338770831377832 0.19303338824827476 1.2056641877934746e-06 5.918773638876529 0.41354135623730803 GGPESPPS(ph)NR ddPTM_A459_Selumetinib_30min_R2 1 GGPESPPSNR 10 0 M0QXZ8;Q6ZW31-2;Q6ZW31 M0QXZ8 SYDE1 Rho GTPase-activating protein SYDE1 1 GGPES(0.04)PPS(0.96)NR 87.184 0.034010000000000006 7808700.0 6948.3 8901.4 10520.0 13167.0 16787.0 13091.0 10813.0 10729.0 8520.7 9160.1 True False 6562.141302248722 9584.108757487824 9843.154653309954 11373.631885658084 14678.066982315891 14894.166421733884 11315.825925553027 10760.219613718433 10225.078088249833 8895.624112201971 0.7376819455812604 1.077395878760375 1.1065164769955007 1.2785648024467529 1.6500322852201281 1.674325065208614 1.2720665557384903 1.2096081711634858 1.149450331902432 1.0 13.11888011241333 -5.00880502272157 1.2491115792801188 1.348442212578181 0.6431316500163595 0.4238478290955082 0.20319408927997465 0.9900973483316434 1.7752987812089793 0.06790604021677293 0.8130271231102842 9.799298279026787e-06 5.00880502272157 -0.7053105625618215 GGPGAAPGGAS(ph)PASSSSAAS(ph)SPSSGR ddPTM_A459_Selumetinib_30min_R2 1 GGPGAAPGGASPASSSSAASSPSSGR 26 0 Q9BXK1 Q9BXK1 KLF16 Krueppel-like factor 16 2 GGPGAAPGGAS(0.998)PAS(0.001)SSSAAS(0.716)S(0.282)PS(0.001)SGR 202.66 1.4912e-39 0.0 4487.8 5219.2 5495.7 6356.2 7238.7 4921.2 4866.5 4405.3 5344.9 6305.5 True False 4238.386042086812 5619.495857626938 5142.112645265738 5490.474594943414 6329.30979120093 5599.050629794269 5092.801892786809 4418.118693663326 6414.029348983831 6123.4438313434985 0.6921572498782764 0.9177018704512241 0.8397419469980745 0.8966318212702198 1.0336193105591471 0.9143630257756156 0.8316891659426613 0.7215088135615314 1.0474545902018306 1.0 12.580127539054304 GGPGAAPGGASPASSS(ph)SAASSPSSGR ddPTM_A459_Selumetinib_30min_R2 1 GGPGAAPGGASPASSSSAASSPSSGR 26 0 Q9BXK1 Q9BXK1 KLF16 Krueppel-like factor 16 1 GGPGAAPGGAS(0.095)PAS(0.202)S(0.202)S(0.315)S(0.018)AAS(0.149)S(0.018)PSSGR 245.63 5.639899999999999e-47 1827700.0 6030.8 6096.3 6248.9 6616.9 7568.9 6644.8 4367.8 5174.4 6530.5 5465.6 True False 5695.632279205208 6563.866607305927 5846.852577287888 5715.66680521083 6618.027115175476 7560.060884511294 4570.911354631507 5189.456647331968 7836.782477415651 5307.793926665771 1.0730695949951974 1.236646843866674 1.1015598303306287 1.0768441435708251 1.2468508021623141 1.42433202738531 0.8611697096354386 0.9777049974115819 1.4764669815164677 1.0 12.373896644302262 -10.755965730186665 5.152146763666711 0.9999823987706336 1.1573247984407962 0.06835213653035577 0.18003010911831044 3.627271884435067e-05 5.399011946652852e-06 0.17371103060131096 0.042126402331115836 1.7540189045417755e-11 10.755965730186665 0.1573423996701626 GGPGAAPGGASPASSSSAAS(ph)SPSSGR ddPTM_A459_Selumetinib_30min_R1 1 GGPGAAPGGASPASSSSAASSPSSGR 26 0 Q9BXK1 Q9BXK1 KLF16 Krueppel-like factor 16 1 GGPGAAPGGASPASSSSAAS(0.499)S(0.499)PS(0.001)S(0.001)GR 277.8 2.2773e-87 3108400.0 582.33 765.78 582.46 787.19 734.75 755.06 547.19 520.65 210.03 556.04 True False 595.8971559830684 676.122121598536 503.3651312237624 649.7220438863986 668.2919922306484 747.4647819396278 505.9150177548036 506.8406706904533 356.4055700157319 627.4131502882584 0.9497683555234532 1.0776346037501743 0.8022865491303403 1.0355569429615727 1.0651545826280635 1.1913438243942016 0.8063506758224086 0.8078260241398999 0.5680556262679306 1.0 9.293271957491202 -7.418360643949966 7.7076060628773515 0.7739922438350351 1.0155039286024163 0.39762043867451535 0.1349497458045656 0.27651341597712875 18.08926377391186 0.05638365280413611 0.03782815318680089 3.8162723086129344e-08 7.418360643949966 0.24151168476738127 GGPGAAPGGASPASSSSAAS(ph)SPSSGR ddPTM_A459_Selumetinib_30min_R2 2 GGPGAAPGGASPASSSSAASSPSSGR 26 0 Q9BXK1 Q9BXK1 KLF16 Krueppel-like factor 16 1 GGPGAAPGGAS(0.001)PAS(0.062)S(0.02)S(0.006)S(0.013)AAS(0.78)S(0.117)PS(0.001)SGR;GGPGAAPGGASPASSSSAAS(0.591)S(0.404)PS(0.005)SGR 323.22 7.364699999999994e-151 24577000.0 15773.599999999999 15915.0 17251.3 17706.0 19958.8 13774.7 15782.9 16153.900000000001 12971.4 16412.8 True False 14896.966458723778 17135.629325209367 16141.370139795261 15294.41225544634 17451.397110064114 15672.039890723223 16516.836123223035 16200.90517457789 15566.04245119812 15938.919818424314 0.9346283580336412 1.075080966616178 1.0127016337165413 0.9595639120893896 1.094892082328658 0.9832560844309791 1.0362581850829495 1.016436832554408 0.9766058571425165 1.0 13.960266240659088 -4.73148370992347 24.58981965910642 1.0177342254099078 0.9346277386498656 0.2747504856704098 0.04023767670241298 4104.721990796172 3369230.8689081874 0.009513619471339807 1.1423270489948678 1.855736415478643e-05 4.73148370992347 -0.08310648676004218 GGPGAAPGGASPASSSSAASS(ph)PSSGR ddPTM_A459_Selumetinib_30min_R1 3 GGPGAAPGGASPASSSSAASSPSSGR 26 0 Q9BXK1 Q9BXK1 KLF16 Krueppel-like factor 16 1 GGPGAAPGGASPASSSSAAS(0.048)S(0.942)PS(0.01)SGR;GGPGAAPGGASPASSSSAAS(0.052)S(0.946)PS(0.002)SGR;GGPGAAPGGASPASSSSAAS(0.209)S(0.791)PSSGR 320.88 1.1583999999999993e-150 42389000.0 4669.1 6239.799999999999 4251.71 5084.6 4922.5 4523.0 4861.4 4367.68 2175.31 3614.8399999999997 True False 4777.88094551293 5509.24131519568 3674.3511349712967 4196.670059762935 4477.260744137962 4477.502726555416 4494.7006840644035 4251.834938175894 3691.3421916436787 4078.83992552336 1.1713823128030394 1.3506882877951587 0.9008323940292502 1.0288881486871433 1.0976799349544173 1.09773926123882 1.1019556457557438 1.0424127977099609 0.9049980531339531 1.0 11.993943174193806 -5.255093364638196 24.98715628894012 1.0318640885707921 1.261035304336069 0.58621969965596 0.08003698137183325 357.8460705015978 1408993.9480721292 0.02083933842787789 0.0522679091809778 5.557847618047952e-06 5.255093364638196 0.22917121576527677 GGPGAAPGGASPASSSSAASS(ph)PSSGR ddPTM_A459_Selumetinib_30min_R2 1 GGPGAAPGGASPASSSSAASSPSSGR 26 0 Q9BXK1 Q9BXK1 KLF16 Krueppel-like factor 16 1 GGPGAAPGGASPASSSSAAS(0.127)S(0.863)PS(0.01)S(0.001)GR 321.58 1.0326999999999993e-150 17213000.0 13925.0 13197.0 12642.0 12653.0 15889.0 14247.0 13716.0 9991.3 10534.0 12776.0 True False 13151.104246191648 14209.167464956836 11828.627483568862 10929.639572357539 13892.881770537744 16209.39492861071 14353.821177738384 10020.373028851243 12641.094344551952 12407.123683965507 1.0599639836900823 1.145242670815011 0.9533738668903357 0.880916467890345 1.1197504050429008 1.3064587201269795 1.1569015948707528 0.8076306228655713 1.0188577680489168 1.0 13.598881076980366 -7.747559160331918 24.98211413877835 0.9349330999784794 1.0874448161996129 0.23583444135881282 0.12084816690102919 350.73158067706817 631261.6633178213 0.0632140273811145 0.03625549130769861 1.7883019069918674e-08 7.747559160331918 0.15251171622113346 GGPGS(ph)AVSPYPTFNPSSDVAALHK ddPTM_A459_Selumetinib_30min_R1 1 GGPGSAVSPYPTFNPSSDVAALHK 24 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 GGPGS(0.782)AVS(0.218)PYPTFNPSSDVAALHK 157.73 8.747799999999999e-13 52659000.0 3082.5 4764.7 4655.5 6264.9 5178.8 4212.8 4562.2 4692.1 1766.4 3148.7 True False 3154.316252499111 4206.846708951067 4023.308670831002 5170.852821737956 4710.378454391403 4170.423056916354 4218.0695809517065 4567.650265911222 2997.451787248435 3552.8663159352564 0.8878229496987896 1.1840712075437763 1.132412061997865 1.4554031483103471 1.3257967048364563 1.1738193013937064 1.18723002946463 1.2856240172686695 0.8436714249011606 1.0 11.79476768991842 -8.260914216256866 24.99638173156498 0.9218356949488541 1.2118423597607841 0.3834270704262932 0.14286043112953378 48.172331117670275 2293178.7720716796 0.11485655805369792 0.037364376497212255 5.4838527367838424e-09 8.260914216256866 0.29000666481193005 GGPGS(ph)AVSPYPTFNPSSDVAALHK ddPTM_A459_Selumetinib_30min_R2 2 GGPGSAVSPYPTFNPSSDVAALHK 24 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 GGPGS(0.912)AVS(0.088)PYPTFNPSSDVAALHK;GGPGS(0.882)AVS(0.041)PY(0.014)PT(0.063)FNPSSDVAALHK 130.51 7.6752e-08 15083500.0 31578.9 36707.6 38953.7 41030.0 46293.3 23285.8 25801.2 31470.0 26527.3 31043.0 True False 29823.871158352704 39522.9548864628 36447.46135158177 35441.64321930212 40477.52178664706 26493.20758255372 27001.006924107875 31561.572489861035 31833.50123469078 30146.707930599656 0.9892911433981398 1.311020592279863 1.2090030339460944 1.1756389221964754 1.3426846433723323 0.8788093095784585 0.8956535813551032 1.046932638964046 1.0559528193915657 1.0 14.879712845637906 -6.767094358032538 24.999953009141286 0.9734144489464682 1.2099209784500338 0.5558754074830536 0.10277268540656975 104.74333452143789 463054.24920082535 0.03564210664467101 0.032295873498984516 1.7096438248681303e-07 6.767094358032538 0.23650652950356554 GGPGSAVS(ph)PYPTFNPSSDVAALHK ddPTM_A459_Selumetinib_30min_R1 3 GGPGSAVSPYPTFNPSSDVAALHK 24 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 GGPGS(0.008)AVS(0.992)PYPTFNPSSDVAALHK;GGPGS(0.339)AVS(0.661)PYPTFNPSSDVAALHK;GGPGS(0.006)AVS(0.719)PY(0.097)PT(0.179)FNPSSDVAALHK 198.83 6.516299999999999e-31 657638000.0 8606.8 10119.599999999999 10113.6 11043.300000000001 10475.699999999999 8335.599999999999 9368.199999999999 9268.4 4337.06 7195.1 True False 8807.321694082519 8934.792527525593 8740.228670028227 9114.794963415023 9528.174784635052 8251.751432119248 8661.549131618907 9022.571923993846 7359.6740536705765 8118.661171208992 1.0848243951004763 1.100525362384974 1.0765603448292047 1.1226968056923716 1.1736140459247866 1.0163931291260475 1.0668691486146935 1.1113374155815705 0.9065132659766623 1.0 12.987026120334864 -8.254073513103101 24.89287738878293 0.9532566296454033 1.0938373626239346 0.6252592563856427 0.04361499784224265 307.089238106686 1037814.2455457351 0.031058118313886357 0.011211572063313024 5.5709144198441265e-09 8.254073513103101 0.14058073297853135 GGPGSAVS(ph)PYPTFNPSSDVAALHK ddPTM_A459_Selumetinib_30min_R2 4 GGPGSAVSPYPTFNPSSDVAALHK 24 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 GGPGS(0.006)AVS(0.99)PY(0.004)PTFNPSSDVAALHK;GGPGS(0.001)AVS(0.995)PY(0.004)PTFNPSSDVAALHK;GGPGS(0.017)AVS(0.975)PY(0.008)PTFNPSSDVAALHK;GGPGS(0.035)AVS(0.962)PY(0.002)PTFNPSSDVAALHK 130.51 7.6752e-08 290622000.0 804391.0 689082.0 865614.0 954956.0 851456.0 601317.0 650812.0 664899.0 655429.0 739488.0 True False 759686.168452304 741932.3736521471 809921.3376492639 824889.3454090167 744488.485166782 684142.9585377546 681076.0475595124 666833.7460100447 786533.1142163777 718137.0600194325 1.0578567946789255 1.033134780193729 1.1278088581410182 1.1486516868892627 1.0366941446339457 0.9526634908930086 0.9483928423650533 0.9285605535968308 1.095240947730917 1.0 19.453899690267463 -6.534828304076739 5.492892660532588 0.9791927244135037 1.0908386324322628 0.48015154370736235 0.05223099876455849 0.14743518751036938 14.45992249142221 0.017765134521192466 0.018425313969009382 2.9185806306707456e-07 6.534828304076739 0.11164590801875907 GGPGSAVSPYPT(ph)FNPSSDVAALHK ddPTM_A459_Selumetinib_30min_R2 3 GGPGSAVSPYPTFNPSSDVAALHK 24 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 GGPGS(0.01)AVS(0.204)PY(0.182)PT(0.599)FNPS(0.002)S(0.003)DVAALHK;GGPGSAVSPY(0.005)PT(0.966)FNPS(0.022)S(0.006)DVAALHK;GGPGSAVS(0.001)PY(0.003)PT(0.996)FNPSSDVAALHK 142.3 3.5415e-08 23012300.0 86486.0 83662.0 84895.0 85568.0 79502.0 56947.2 61330.4 61891.0 62297.7 74189.0 True False 81679.45435088918 90078.60638427077 79432.94812668706 73913.49078696675 69514.24800310233 64791.15988478835 64182.38512388207 62071.09256339337 74758.98074317393 72046.97080382881 1.1336972733147648 1.2502761098664221 1.1025161396857193 1.0259069876542088 0.964846227780726 0.8992905484007544 0.890840855733399 0.8615364653206865 1.0376422479541776 1.0 16.136650153486393 -5.828693718625714 1.5669413259952836 0.9283581295552246 1.1944727989041386 0.7504465327649056 0.05756857289895002 0.17478973686537566 0.8730705521498291 0.018585514513258915 0.03824830660436745 1.483563983369846e-06 5.828693718625714 0.26611466934891403 GGPGSAVSPYPTFNPSSDVAALHK ddPTM_A459_Selumetinib_30min_R1 1 GGPGSAVSPYPTFNPSSDVAALHK 24 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 0 166.21 1.5046e-15 27943000.0 3753.5 4251.1 4362.8 5033.0 4747.3 4364.9 4399.5 4229.1 2480.8 3263.2 False True 3840.9492469603933 3753.379235717229 3770.355723144988 4154.081031110973 4317.9075532038905 4320.993069012102 4067.6421729422286 4116.9305299471725 4209.736409536865 3682.0635062597007 1.0431512765683097 1.019368413753942 1.0239790043640438 1.1281937489803795 1.1726868767644072 1.1735248622589445 1.1047180924574016 1.1181041616876448 1.1433090174517881 1.0 11.846298794396029 -5.762999620743133 24.789025549760147 1.128776856242192 1.0278864313354583 0.4381209507254945 0.04662515171855809 29.3286355161965 465987.279011322 0.012449610313234645 0.01961637862779223 1.7258393991154027e-06 5.762999620743133 -0.10089042490673372 GGPPFAFVEFEDPRDAEDAVYGR ddPTM_A459_Selumetinib_30min_R2 1 GGPPFAFVEFEDPRDAEDAVYGR 23 1 J3KTL2;Q07955;Q07955-3;Q07955-2 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 59.154 0.036771 1240800.0 4663.7 3571.0 3727.8 3951.5 2482.9 2204.4 2830.0 1197.7 2364.4 3312.1 False True 4404.510224270301 3844.8842174252395 3487.9574065217566 3413.29888328229 2170.9759045923697 2508.0360904491763 2961.600607538614 1201.1851087100915 2837.3460668557655 3216.4710671307234 1.3693610582355948 1.1953734814269903 1.0844050307697046 1.0611937157349118 0.6749558318051356 0.7797477540149268 0.920760841844143 0.3734481310853567 0.8821301381662484 1.0 11.651262996043744 -5.73408716274715 1.0398952905742247 0.738795640862861 1.336417653430433 0.5829788082673217 0.171949134777742 0.41862962370420714 0.8511673886617983 0.06400219249212985 0.19597794487306305 1.8446451624013405e-06 5.73408716274715 0.5976220125675721 GGPPS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 GGPPSPTK 8 0 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 GGPPS(0.993)PT(0.007)K 90.149 0.028672000000000007 18608000.0 3197.7 3977.9 4345.7 4240.6 3868.7 4356.2 3568.6 3980.7 3392.3 3825.3 True False 3272.200188358934 3512.165618724463 3755.5778092214123 3500.05881592076 3518.7767680744582 4312.380583113136 3299.4176289036564 3875.1189048640867 5756.485336210862 4316.314516577358 0.7581004988843216 0.8136954814658529 0.8700890064423331 0.8108905879027899 0.8152271468078024 0.9990885897102463 0.764406211880951 0.8977841837014419 1.3336575252109977 1.0 12.075584278073348 -8.112395793754585 6.15326362998263 1.162270565649708 0.8381364748285305 0.6411420935360507 0.09833823655921359 0.1343283343005305 6.324524639493759 0.06352673783607907 0.023504547780976628 7.719767243523424e-09 8.112395793754585 -0.3241340908211776 GGPPS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 GGPPSPTK 8 0 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 GGPPS(0.982)PT(0.018)K 83.869 0.037860000000000005 23515000.0 69205.0 54828.0 52340.0 65651.0 64236.0 43448.0 67938.0 89568.0 56374.0 74854.0 True False 65358.863149565 59033.131300193476 48972.5013834832 56709.22054570819 56166.099402873864 49432.56761832512 71097.25161659312 89828.6280512193 67650.37522116685 72692.77052595146 0.899110911259487 0.8120908155387823 0.673691496818104 0.7801218764314793 0.7726504162174209 0.6800204100169438 0.9780512023710977 1.235729872465795 0.9306341570378794 1.0 16.149524271273663 -7.4309238838033265 5.04712700519827 1.0705492775911438 0.7692335362536421 0.6622494663106766 0.09407116146246138 0.12399672965160087 5.1185305292908 0.03985658166628637 0.026104752447394405 3.707456944694573e-08 7.4309238838033265 -0.3013157413375017 GGPS(ph)PGDVEAIK ddPTM_A459_Selumetinib_30min_R2 2 GGPSPGDVEAIK 12 0 P09661;H0YLR3;H0YMA0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 GGPS(1)PGDVEAIK;GGPS(1)PGDVEAIK 118.76 0.004442 8275000.0 82025.0 76819.0 78574.0 76026.0 71441.0 66160.0 71372.0 66183.0 58491.0 72110.0 True False 77466.37887209124 82710.77028798363 73518.63438490266 65671.12764783483 62465.942889356644 75272.93945931664 74690.93942093494 66375.58157281452 70190.83437508914 70027.99693571965 1.1062201156945766 1.1811100403729353 1.0498463129309146 0.9377838938919801 0.8920138462149018 1.074897794497984 1.0665868322564689 0.9478434979904142 1.0023253191079984 1.0 16.095644201109224 -5.473793388823877 4.66957171111628 0.9893607854025668 1.1408970410771335 0.554278510718534 0.05512665878443173 0.159891632566554 7.577723451430217 0.015836338909744004 0.033062651052780695 3.3589737599266965e-06 5.473793388823877 0.15153625567456674 GGQGDPAVPAQQPADPS(ph)TPER ddPTM_A459_Selumetinib_30min_R1 1 GGQGDPAVPAQQPADPSTPER 21 0 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 GGQGDPAVPAQQPADPS(0.5)T(0.5)PER 86.189 0.0010474 16768000.0 6067.8 7241.2 5374.4 4898.9 5486.4 5079.1 6175.7 5897.4 3715.0 5993.4 True False 6209.1679341165 6393.396937657449 4644.585999466037 4043.3990787422053 4990.156088702593 5028.008865453818 5709.861976915406 5740.981794545049 6304.083667135383 6762.711270659749 0.918147719991416 0.9453896051122893 0.6867934787659397 0.5978961568690103 0.7378928197559688 0.7434900980126128 0.8443155042989687 0.8489171819965894 0.9321828797402401 1.0 12.72338604485803 -8.139034946938414 1.2075468198613586 0.9944590375125784 0.7687953721307051 0.37939079012480736 0.09684810318731722 0.5413040301087404 1.484081035656503 0.10220661840196327 0.033993490303063305 7.260475312743059e-09 8.139034946938414 -0.2256636653818732 GGQGDPAVPAQQPADPS(ph)TPERQSSPSGS(ph)EQLVR ddPTM_A459_Selumetinib_30min_R2 1 GGQGDPAVPAQQPADPSTPERQSSPSGSEQLVR 33 1 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 2 GGQGDPAVPAQQPADPS(0.473)T(0.473)PERQS(0.19)S(0.19)PS(0.147)GS(0.527)EQLVR 53.545 0.0041146 6753500.0 8436.8 10414.0 9197.7 12190.0 11853.0 5511.2 4790.4 3509.4 4375.3 10339.0 True False 7967.916431186334 11212.720313712241 8605.929995698572 10529.700971077089 10363.920172835538 6270.317774307525 5013.1630919975205 3519.611772987553 5250.48225609627 10040.48620605192 0.7935787438643817 1.1167507313494196 0.8571228344013194 1.04872421065927 1.032212978549651 0.6245034000971068 0.4992948537667257 0.3505419658727384 0.5229310760799146 1.0 13.293541512391526 -6.842032790887601 4.7453375391273465 0.5430409520670086 0.9759185096685888 0.504221166832467 0.18048479203719417 0.14985793215467977 6.080230641076476 0.06156717476916599 0.05470316676587171 1.438689947583903e-07 6.842032790887601 0.4328775576015802 GGQGDPAVPAQQPADPST(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 GGQGDPAVPAQQPADPSTPER 21 0 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 GGQGDPAVPAQQPADPS(0.01)T(0.99)PER;GGQGDPAVPAQQPADPS(0.008)T(0.992)PER 261.92 2.4567999999999997e-48 54646000.0 10527.1 13526.6 10298.7 9796.9 12372.0 10921.9 12684.9 11053.5 6707.200000000001 9631.6 True False 10772.360947829164 11942.89938365426 8900.193106709747 8086.055325589325 11252.954784454016 10812.035602291766 11728.067780328414 10760.325273171851 11381.628525494063 10867.909679728777 0.991208177587468 1.0989141183175817 0.8189424985110718 0.7440304128283042 1.0354295458899 0.9948588018226514 1.0791466000314702 0.990100726843765 1.0472693333772818 1.0 13.40778686042175 GGQGDPAVPAQQPADPST(ph)PER ddPTM_A459_Selumetinib_30min_R2 4 GGQGDPAVPAQQPADPSTPER 21 0 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 GGQGDPAVPAQQPADPS(0.041)T(0.959)PER;GGQGDPAVPAQQPADPS(0.009)T(0.991)PER;GGQGDPAVPAQQPADPS(0.003)T(0.997)PER;GGQGDPAVPAQQPADPS(0.01)T(0.99)PER 307.54 1.600499999999999e-117 93141000.0 238083.0 217171.0 256228.0 267484.0 288319.0 200000.0 219237.0 225286.0 213630.0 229641.0 True False 224851.2999817628 233827.3173851737 239742.56943995328 231052.21776436252 252097.7896154364 227548.18458076377 229431.95490987404 225941.5449618949 256361.96932092524 223010.66765102744 1.0082535618144313 1.0485028355283543 1.0750273606422647 1.0360590378838679 1.130429285158346 1.0203466362283473 1.0287936327283447 1.0131423188932547 1.14955025255602 1.0 17.766753197134577 -4.783705380468774 3.966052603419988 1.0570180930313486 1.0039425721793274 0.08635790713222846 0.0469457336767584 0.5911762149261847 17.325640517496552 0.011327825159137946 0.0898784481195239 1.6454876213222105e-05 4.783705380468774 -0.053075520852021274 GGQVSLTVHGTQQVHS(ph)PPEQSPVQANSSSSK ddPTM_A459_Selumetinib_30min_R2 1 GGQVSLTVHGTQQVHSPPEQSPVQANSSSSK 31 0 P22670 P22670 RFX1 MHC class II regulatory factor RFX1 1 GGQVSLTVHGT(0.001)QQVHS(0.999)PPEQSPVQANSSSSK 104.65 2.9476e-11 4985900.0 8905.7 5727.2 16372.0 23460.0 19894.0 12009.0 9794.4 13039.0 13704.0 17747.0 True False 8410.756846341752 6166.457824149491 15318.643344485812 20264.7075292427 17394.73786538346 13663.13074315196 10249.859007235416 13076.941331277343 16445.182921752414 17234.5979977564 0.48801584159007744 0.3577952804557577 0.8888309055122722 1.175815503899816 1.0092917669241783 0.7927733936660796 0.5947257376452728 0.7587610301661635 0.9541959101043871 1.0 14.07302002734618 -5.2664324061438705 24.08579426268888 0.8876625296095942 0.42290553170171546 0.6043656545644512 0.15322656458778455 171.1692517561729 825708.713161725 0.0454351746354699 0.0996973718714304 5.41461514722853e-06 5.2664324061438705 -0.4647569979078788 GGRS(ph)PDEVTLTSIVPTR ddPTM_A459_Selumetinib_30min_R1 3 GGRSPDEVTLTSIVPTR 17 1 A0A0C4DGG1;Q9UKS6;H0YDM6 A0A0C4DGG1 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 1 GGRS(1)PDEVTLTSIVPTR;GGRS(1)PDEVTLTSIVPTR;GGRS(1)PDEVTLTSIVPTR 107.13 0.0013627 33065100.0 3337.38 3998.38 4245.1 3944.8 3174.73 3719.61 3128.1400000000003 3334.5699999999997 2139.68 2545.46 True False 3415.1344605889653 3530.24781080357 3668.638736665169 3255.9147330670703 2887.5762320441045 3682.194100535663 2892.1818813200384 3246.1263713901185 3630.8806839559174 2872.1945858800636 1.1890331098658973 1.2291116445099326 1.2772946355029313 1.1335982419413382 1.0053553635396635 1.2820141499596236 1.0069588932234028 1.1301902689143462 1.264148571898859 1.0 11.487937777059324 -14.52276536500118 0.024107415383703378 2.552047395896749e-07 1.9092799561606129 0.20520444964635964 0.09723490650173292 3722.733295201014 6.755460215503154 383.35259845094845 184.92398827457833 3.0007833054653337e-15 14.52276536500118 1.9092797009558733 GGRS(ph)PRPGSSAPEHSPR ddPTM_A459_Selumetinib_30min_R2 2 GGRSPRPGSSAPEHSPR 17 2 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 GGRS(0.987)PRPGS(0.01)S(0.003)APEHSPR;GGRS(0.898)PRPGS(0.099)S(0.004)APEHSPR 70.78399999999998 0.01221 1288340.0 2169.9 1860.35 1608.63 2710.66 1879.6799999999998 1836.1299999999999 1858.96 2157.11 1729.21 378.05 True False 2049.305644797934 2003.0328630319357 1505.1324971439162 2341.4634318506814 1643.5377938475913 2089.0402407713887 1945.4053234593578 2163.3868329712145 2075.100318164293 367.13471420813727 5.58189014955457 5.455852539992635 4.099673604524963 6.3776683087594135 4.476661373176036 5.690119075983272 5.298886888578076 5.892624013061156 5.652149573052551 1.0 8.520165723847477 GGS(ph)GGGGEGIQDR ddPTM_A459_Selumetinib_30min_R2 1 GGSGGGGEGIQDR 13 0 O43823 O43823 AKAP8 A-kinase anchor protein 8 1 GGS(1)GGGGEGIQDR 97.797 0.016364 0.0 6899.0 5682.1 5222.7 7545.3 8093.5 8757.2 2024.0 5487.8 6969.5 5772.7 True False 6515.581198885185 6117.898799168846 4886.6771680458105 6517.6171236315 7076.722173191974 9963.42481005332 2118.1200104799145 5503.768589445801 8363.594744100506 5606.027151724145 1.1622457441864698 1.091307379288606 0.8716827506878739 1.1626089113084288 1.2623417585509755 1.7772701666257624 0.37782906738660416 0.9817591746328066 1.491893370785453 1.0 12.452763016467905 -10.943606515336986 4.2332596555637645 0.999578293798079 1.1194592405545503 0.01148002294686945 0.3502417346468181 0.0014092499485195225 0.00019283939932823063 0.3428365146192102 0.0828589660173226 1.1386584795334075e-11 10.943606515336986 0.11988094675647121 GGS(ph)GGGGGGGGGGYNR ddPTM_A459_Selumetinib_30min_R2 4 GGSGGGGGGGGGGYNR 16 0 H3BPE7;P35637-2;P35637;H3BNZ4 H3BPE7 FUS RNA-binding protein FUS 1 GGS(1)GGGGGGGGGGYNR;GGS(1)GGGGGGGGGGYNR;GGS(1)GGGGGGGGGGYNR;GGS(1)GGGGGGGGGGYNR 137.73 0.00040652 11202800.0 4747.28 2575.17 5060.71 3866.98 6923.01 3911.96 5334.52 9148.08 3606.36 8009.37 True False 4483.4451824675525 2772.6772585233693 4735.1094282844315 3340.290653087424 6053.279591305341 4450.79698076282 5582.585750150849 9174.699398253828 4327.732770117559 7778.118677257576 0.576417687682844 0.3564714519759636 0.6087731011522629 0.4294471184727603 0.7782446941835063 0.5722202457229787 0.7177295669804781 1.1795525086393592 0.5563983978248375 1.0 12.925205532006178 -6.981760227275308 0.7435430066069413 0.9204818141793981 0.4743245028487079 0.43575893938869803 0.1798256633588904 0.6083198121604093 0.7071442223070482 0.1317267625227772 0.10490765142255494 1.0428930487092569e-07 6.981760227275308 -0.4461573113306902 GGS(ph)GSGPTIEEVD ddPTM_A459_Selumetinib_30min_R2 1 GGSGSGPTIEEVD 13 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 GGS(0.995)GS(0.005)GPTIEEVD 171.67 0.0001958 5992200.0 56680.0 62938.0 54618.0 62606.0 61371.0 46602.0 50904.0 55967.0 39303.0 51184.0 True False 53529.95250801742 67765.1422224335 51103.93734358206 54078.954798626124 53661.02631629884 53021.00248916375 53271.13686436244 56129.85470416435 47164.69821757406 49706.18492799706 1.076927400192941 1.3633140889930724 1.0281202916218524 1.087972349456377 1.0795643719997954 1.066688231373388 1.071720489945657 1.1292328064499906 0.948869809378762 1.0 15.601137756684807 -3.8889730936619507 0.2370674261215217 0.9988102753403413 1.4700779628048286 0.26584517409754604 0.08946438432780894 21.85179521915412 0.7531041809801877 0.1315099076834209 3.2279391821483485 0.0001291299272462118 3.8889730936619507 0.47126768746448733 GGS(ph)GSHNWGTVK ddPTM_A459_Selumetinib_30min_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 GGS(0.809)GS(0.191)HNWGTVK 134.06 0.0016537 3523200.0 1550.6 2015.4 1625.9 1517.7 1662.0 1103.1 1679.0 1668.5 924.9 1649.3 True False 1586.7259630576234 1779.436031065959 1405.1117104294112 1252.6621857574246 1511.6723934499328 1092.0038155346633 1552.3516782293445 1624.2459599481824 1569.4877479767197 1861.003720542452 0.8526183723024041 0.9561700556661341 0.7550289636282105 0.6731110593332367 0.8122887540543472 0.5867821775317903 0.834147541508869 0.8727795339789765 0.8433555132921711 1.0 10.861865224316421 -8.550599716871606 1.0984438994948211 0.9943857258899117 0.7798128272314699 0.3072823505453639 0.0969782170154422 0.7449749436590795 1.9640332470741453 0.09890280787292467 0.03174741667966297 2.814493714656612e-09 8.550599716871606 -0.21457289865844176 GGS(ph)PAPLPAKVDEATSGLIR ddPTM_A459_Selumetinib_30min_R1 1 GGSPAPLPAKVDEATSGLIR 20 1 A0A087WWH3;Q9NZM4-2;Q9NZM4 A0A087WWH3 GLTSCR1 Glioma tumor suppressor candidate region gene 1 protein 1 GGS(1)PAPLPAKVDEATSGLIR 86.573 0.0012380999999999998 17988000.0 2592.7 2886.7 4641.7 4404.5 3533.2 3062.7 3578.8 3419.2 1813.6 2427.3 True False 2653.1048654840056 2548.7238220095787 4011.3826350330296 3635.3367577048 3213.622683837123 3031.8920187091035 3308.8482346915916 3328.511708873137 3077.5467398968294 2738.867598904198 0.9686867910465969 0.9305757689890908 1.464613563882371 1.3273137990165254 1.1733399179729869 1.1069874352167086 1.2081081378360308 1.2152875554133582 1.1236566313494434 1.0 11.419363810281423 -10.225386830536605 14.985481019263654 0.9999998102962858 1.1759392641266222 0.10282615645575299 0.14814912856983461 0.0 0.0 0.15307533185750005 0.037126221289702874 5.951318173843939e-11 10.225386830536605 0.17593945383033638 GGS(ph)PDLWK ddPTM_A459_Selumetinib_30min_R1 4 GGSPDLWK 8 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 GGS(1)PDLWK;GGS(1)PDLWK;GGS(1)PDLWK;GGS(1)PDLWK 140.45 0.0023409000000000004 423144500.0 27632.6 30667.6 31925.1 34078.8 29096.0 27208.600000000002 29730.399999999998 27833.6 16272.8 23653.2 True False 28276.385816320173 27077.023135019554 27589.84677202164 28127.577318304116 26464.271937316036 26934.906187432203 27487.81199191762 27095.362511725343 27613.75308171215 26689.318621678718 1.059464507773246 1.0145265796716862 1.033741144279774 1.0538889252667978 0.9915679119593602 1.0092017173324914 1.0299180875149925 1.0152137226057474 1.034636870020449 1.0 14.703974853494175 -1.5228787452803376 0.5960103978677898 1.0179583592144583 3.0499778146782877 0.2743881128834549 0.01788321354126782 258.75396196422304 2.0332162386389445 0.00827516951599689 683.9027656473646 0.029999999999999995 1.5228787452803376 2.0320194554638293 GGS(ph)PDLWK ddPTM_A459_Selumetinib_30min_R2 6 GGSPDLWK 8 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 GGS(1)PDLWK;GGS(1)PDLWK;GGS(1)PDLWK;GGS(1)PDLWK;GGS(1)PDLWK;GGS(1)PDLWK 134.23 0.0028606 368052000.0 1940327.0 1623402.0 1941603.0 2085743.0 1828917.0 1389773.0 1537306.0 1579183.0 1236995.0 1732824.0 True False 1832491.393084403 1747911.7133398403 1816682.3768375053 1801661.2052926323 1599152.0957345695 1581201.6156468077 1608793.775114048 1583778.1610821816 1484428.5645281053 1682792.868702557 1.0889583781616952 1.0386968864964887 1.0795638670837593 1.0706375328781395 0.9502964538752324 0.9396293774800242 0.9560260237817845 0.9411604901221644 0.8821219724282575 1.0 20.682426178739583 -6.277283252651155 5.732297662563303 0.9416747021898736 1.0683724312324503 0.8117395813633698 0.029382148537524858 0.06849241126099403 8.450003002903841 0.008776487399519535 0.010413535464572877 5.281007051078662e-07 6.277283252651155 0.1266977290425767 GGS(ph)PDQYPYR ddPTM_A459_Selumetinib_30min_R2 1 GGSPDQYPYR 10 0 A0A087WZG6;A0A087X1S9;Q8TEW8-5;Q8TEW8-2;Q8TEW8;A0A087WYL6;Q8TEW8-6;Q8TEW8-3 A0A087WZG6 PARD3B Partitioning defective 3 homolog B 1 GGS(1)PDQYPYR 136.53 0.0018455 6360100.0 17828.0 16337.0 20994.0 19096.0 16164.0 17882.0 21436.0 17301.0 11336.0 16219.0 True False 16837.19113113857 17589.99536826551 19643.26889653891 16495.091857562602 14133.333812006562 20345.08318336607 22432.81647462819 17351.34304566526 13603.516754304232 15750.715327977196 1.0689794577920866 1.1167743814797602 1.2471350340290621 1.0472598554468957 0.8973137738641139 1.2916926475858612 1.4242411222290279 1.1016225412216645 0.8636761233403156 1.0 13.94312973049156 -8.121330132892515 5.6972024519625935 0.9371364676092266 1.1565027878205414 0.28357155483563234 0.14014366359223057 0.3187999637017484 13.279320712746767 0.10598112861534982 0.038872897493291654 7.56257800235496e-09 8.121330132892515 0.21936632021131475 GGS(ph)PPWAANSQPQPPR ddPTM_A459_Selumetinib_30min_R1 2 GGSPPWAANSQPQPPR 16 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 GGS(1)PPWAANSQPQPPR;GGS(1)PPWAANSQPQPPR 171.15 8.4527e-06 41188000.0 839.0799999999999 864.47 883.5799999999999 1099.6999999999998 1102.3 952.8399999999999 1064.53 883.1600000000001 431.58 730.05 True False 858.6289314345348 763.2574505188004 763.5946891575248 907.6580389256374 1002.5971596268719 943.2552947094993 984.2316450419795 859.7357278920207 732.3597386439533 823.7590287891929 1.0423302220997754 0.9265542760006878 0.9269636659156246 1.1018489718525621 1.2171000554622693 1.145062162287858 1.1948052897079116 1.0436738146053566 0.8890460839262867 1.0 9.686078562603164 -5.769620222442744 24.805746008053056 1.098968791239353 0.9614098733211477 0.23719070591095703 0.09546831352306596 210.86467995579693 639380.087322728 0.02849546910712219 0.04311020861203296 1.699729365340748e-06 5.769620222442744 -0.1375589179182054 GGS(ph)PPWAANSQPQPPR ddPTM_A459_Selumetinib_30min_R2 2 GGSPPWAANSQPQPPR 16 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 GGS(1)PPWAANSQPQPPR;GGS(0.999)PPWAANS(0.001)QPQPPR 147.83 0.000306 40310000.0 16402.7 18422.0 19036.3 22918.4 21849.7 14553.4 19418.9 16602.4 17107.7 20205.9 True False 15491.103599210608 19834.908163933836 17811.52518315631 19796.874383554823 19104.745347203643 16557.998747388425 20321.917327820367 16650.710235324732 20529.71802907644 19622.503165766968 0.7894560377106261 1.0108245617988956 0.9077091252164987 1.0088862881720442 0.9736140789893415 0.8438270391656852 1.0356434730138602 0.8485517925344628 1.0462333911043613 1.0 14.2602214717941 -4.750056154076177 24.99404724395753 0.9576281562487196 0.7894556688859574 0.3565887986032379 0.06984677585455264 555.888393718591 1220482.05342769 0.01588310997101973 0.24436349431106671 1.7780494941958212e-05 4.750056154076177 -0.16817248736276214 GGS(ph)PQMDDIK ddPTM_A459_Selumetinib_30min_R2 1 GGSPQMDDIK 10 0 A0A3B3ITG6;A0A3B3IUB1;Q13144 A0A3B3ITG6 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 1 GGS(1)PQMDDIK 96.23 0.021921 114420000.0 784080.0 615720.0 695130.0 690940.0 744840.0 632740.0 905780.0 919840.0 640430.0 644630.0 True False 740503.97252093 662943.7441481565 650406.0926003178 596832.7800620178 651266.5402459137 719894.1915581614 947900.5647690209 922516.5821122903 768533.8951093034 626017.8569501172 1.1828799519051665 1.0589853576668529 1.038957731603723 0.9533798012882804 1.0403322094018292 1.1499579182379849 1.5141749620163827 1.4736266256152482 1.2276549088447846 1.0 19.255844284575453 -7.0446971469071205 5.929018560899322 1.3436431327110754 1.0522879761495845 0.39074759862508557 0.14314267825883747 0.17986501040016942 16.067273447867137 0.053541718322175365 0.04219654726364879 9.022000630097774e-08 7.0446971469071205 -0.2913551565614909 GGS(ph)PYNQFDIIPGDTLGGHTGPAGDSWLPAK ddPTM_A459_Selumetinib_30min_R1 2 GGSPYNQFDIIPGDTLGGHTGPAGDSWLPAK 31 0 Q9UPQ9;Q9UPQ9-1;H0Y720;Q9UPQ9-2 Q9UPQ9;Q9UPQ9-2 TNRC6B Trinucleotide repeat-containing gene 6B protein 1 GGS(0.711)PY(0.268)NQFDIIPGDT(0.02)LGGHTGPAGDSWLPAK;GGS(0.786)PY(0.002)NQFDIIPGDT(0.21)LGGHT(0.002)GPAGDSWLPAK 106.31 3.1177e-11 62161000.0 5272.2 5958.7 5805.0 5841.4 7498.5 5227.299999999999 7299.5 5461.5 2000.3899999999999 4204.3 True False 5395.032002084612 5261.052633875527 5016.712884582532 4821.309146658379 6820.261998967698 5174.718108008651 6748.892838138838 5316.6432785478 3394.5157272950073 4743.962858349983 1.1372416191220096 1.1089995413044602 1.0574941318843745 1.016304151321981 1.4376718795264514 1.0908007213632551 1.422627672191809 1.1207177284682628 0.7155443304789421 1.0 12.211876999376516 -8.125118940806441 6.150367956020282 0.8632142895074985 1.1803621937747868 0.4217407738853254 0.14931575332569133 0.2192523242462221 9.871728046816203 0.10292718718583811 0.03802998838672536 7.496888629301206e-09 8.125118940806441 0.31714790426728834 GGS(ph)PYNQFDIIPGDTLGGHTGPAGDSWLPAK ddPTM_A459_Selumetinib_30min_R2 1 GGSPYNQFDIIPGDTLGGHTGPAGDSWLPAK 31 0 Q9UPQ9;Q9UPQ9-1;H0Y720;Q9UPQ9-2 Q9UPQ9;Q9UPQ9-2 TNRC6B Trinucleotide repeat-containing gene 6B protein 1 GGS(0.847)PY(0.083)NQFDIIPGDT(0.048)LGGHT(0.013)GPAGDS(0.008)WLPAK 50.111 0.010329 4949800.0 9889.4 7009.4 17367.0 19619.0 22539.0 13226.0 9549.9 12647.0 17753.0 16396.0 True False 9339.786738404857 7546.998441226672 16249.626127759895 16946.858355337277 19707.449318783456 15047.761446325907 9993.98927276785 12683.80067617644 21304.096060264917 15922.604878075961 0.5865740442548398 0.47398013698237473 1.0205381752664235 1.0643270046015916 1.2377025913592126 0.945056513149137 0.6276604455925866 0.7965908074275541 1.3379780647322852 1.0 13.958788754203912 -5.2635069212728895 24.822337801816342 0.9914606594747799 0.5302770613573257 0.4942588358763048 0.19124702508362534 138.10525014079195 1658080.6347784176 0.053342948616688236 0.1207096810533982 5.451212081212326e-06 5.2635069212728895 -0.46118359811745424 GGS(ph)REYDTGGGSSSSR ddPTM_A459_Selumetinib_30min_R1 1 GGSREYDTGGGSSSSR 16 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 GGS(0.905)REYDT(0.086)GGGS(0.008)SSSR 103.39 0.021022 8648700.0 616.24 735.35 1031.4 1021.4 742.56 947.74 671.08 717.22 343.21 538.76 True False 630.5971930056946 649.2548801450597 891.3415450746629 843.031664052602 675.3955791096156 938.2065960790698 620.4598953103925 698.1969957411062 582.4023029333874 607.9150939668044 1.037311294396202 1.0680025657999415 1.4662270338747916 1.386758895147019 1.1110031414131922 1.5433184755407654 1.0206357786935838 1.1485107092590658 0.9580323119353077 1.0 9.24772602978105 GGS(ph)REYDTGGGSSSSR ddPTM_A459_Selumetinib_30min_R2 4 GGSREYDTGGGSSSSR 16 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 GGS(0.999)REYDT(0.001)GGGSSSSR;GGS(0.969)REYDT(0.031)GGGS(0.001)SSSR;GGS(1)REYDTGGGSSSSR;GGS(0.96)REYDT(0.028)GGGS(0.001)S(0.003)S(0.002)S(0.006)R 134.08 0.0022862 46744240.0 24003.7 30593.4 34180.200000000004 30351.5 30005.2 19034.199999999997 12678.02 13626.099999999999 11047.97 25193.0 True False 22669.670448424444 32939.81540671445 31981.083144587927 26217.5733407421 26235.678526108564 21655.988274735853 13267.573051020043 13665.749695077704 13257.872706073622 24465.61263072502 0.9265932061703147 1.3463719835630499 1.3071850530497096 1.0716091085255266 1.0723491343585083 0.8851602697060317 0.5422947404291861 0.558569691319139 0.5418982514839538 1.0 14.578467788551464 -6.87908169227583 1.937146644190419 0.6233408439569951 1.179782917314154 0.6420805725752112 0.16937747329038674 0.1898773586580101 1.4588811501194612 0.07058223555478249 0.059523664856316716 1.3210471173376944e-07 6.87908169227583 0.556442073357159 GGS(ph)SKDLLDNQSQEEQR ddPTM_A459_Selumetinib_30min_R2 2 GGSSKDLLDNQSQEEQR 17 1 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 GGS(0.952)S(0.048)KDLLDNQSQEEQR;GGS(0.907)S(0.093)KDLLDNQSQEEQR 81.992 0.008176899999999999 18875100.0 38774.0 20665.3 41430.0 45010.0 34596.0 51213.0 27168.0 34507.0 38051.0 49513.0 True False 36619.09630462009 22250.262060587447 38764.438905573355 38879.5603534192 30249.741187835836 58267.12588467322 28431.365832370706 34607.40965705863 45662.263233771206 48083.43103977644 0.7615741121786294 0.4627428113892535 0.8061911986585554 0.8085854006810901 0.6291094569106789 1.2117921833920804 0.591292368650881 0.7197366932578099 0.9496465257647202 1.0 15.553252224173056 -5.394236656875223 7.734370052839197 0.8267846112259187 0.6130366273546016 0.19192476798075453 0.18556985127248452 0.4281315973514139 24.73481612293484 0.047001037564446846 0.09830193054099573 4.0342549739187424e-06 5.394236656875223 -0.2137479838713171 GGS(ph)SKDLLDNQSQEEQRR ddPTM_A459_Selumetinib_30min_R1 2 GGSSKDLLDNQSQEEQRR 18 2 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 GGS(0.808)S(0.192)KDLLDNQSQEEQRR;GGS(0.832)S(0.167)KDLLDNQSQEEQRR 78.249 0.014797 41220000.0 3300.2 2649.2 3512.6000000000004 3643.1000000000004 3314.6 2813.6 3044.3 3261.8999999999996 1603.0500000000002 2441.3999999999996 True False 3377.08823892865 2339.030432420333 3035.608213330679 3006.900974456663 3014.7950152401613 2785.2977385444015 2814.6660000200072 3175.383815855544 2720.258767860396 2754.7774712498253 1.2259023729406666 0.8490814437215248 1.1019431678281595 1.0915222756967193 1.0943878577140997 1.0110790318321898 1.0217398789540015 1.152682512106828 0.9874695129644107 1.0 11.427720068398372 -9.45301203556142 13.078448258777739 0.9999999999289416 1.0567605979095962 0.032224386231358704 0.09680947526143245 0.0 0.0 0.08715753162293607 0.02113880640879276 3.52361105957566e-10 9.45301203556142 0.05676059798065458 GGS(ph)SKDLLDNQSQEEQRR ddPTM_A459_Selumetinib_30min_R2 1 GGSSKDLLDNQSQEEQRR 18 2 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 GGS(0.5)S(0.5)KDLLDNQSQEEQRR 76.533 0.016415 7014900.0 10883.0 11495.0 10450.0 16050.0 12920.0 9270.2 6166.0 6881.5 5209.5 11362.0 True False 10278.166428100803 12376.629537749393 9777.658377099719 13863.962312205684 11296.874093734517 10547.085903502972 6452.731217697206 6901.524025706344 6251.545565591739 11033.949537978711 0.9315038457193853 1.121686255238815 0.8861431116251842 1.2564823016895361 1.0238286893420006 0.9558758509090547 0.5848070263043156 0.6254808400157521 0.5665736954908123 1.0 13.429661667210823 -7.12451844352483 3.9691000082959973 0.6641011871581162 1.047164029505052 0.5505095065305713 0.14863808761406008 0.1607230894538464 4.359536712466828 0.056343222835390686 0.043107329031148015 7.507261717650463e-08 7.12451844352483 0.3830628423469358 GGS(ph)TEDASQYYCDKNDNGDSYLVLIR ddPTM_A459_Selumetinib_30min_R1 1 GGSTEDASQYYCDKNDNGDSYLVLIR 26 1 J3KN34;P26045-2;P26045;P26045-3 J3KN34 PTPN3 Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 3 1 GGS(0.709)T(0.284)EDAS(0.001)QY(0.003)Y(0.003)CDKNDNGDSYLVLIR 50.631 0.016983 4766100.0 357.78 357.05 402.21 212.01 322.2 326.57 404.65 376.86 204.42 336.87 True False 366.115577881308 315.24642001195815 347.59209118138483 174.98643342059142 293.0570668890303 323.28500230183596 374.1269247144159 366.86444858619836 346.88580975392034 380.11054589167253 0.9631818475924292 0.8293545743974177 0.9144500065526856 0.460356691788448 0.7709785220548667 0.8505025861449494 0.9842582079294325 0.9651519868400359 0.9125919117560582 1.0 8.570275242058418 -7.06385623965691 3.426516457852759 0.9618747506293982 0.780107004988514 0.3025776064757386 0.12689533868214542 0.3373604705850519 7.781070439910203 0.05392271422159831 0.04212810837470845 8.632642585763079e-08 7.06385623965691 -0.18176774564088416 GGSDGT(ph)PRGS(ph)PSPASVSSGR ddPTM_A459_Selumetinib_30min_R2 1 GGSDGTPRGSPSPASVSSGR 20 1 P10398;Q96II5 P10398 ARAF Serine/threonine-protein kinase A-Raf 2 GGS(0.182)DGT(0.818)PRGS(0.914)PS(0.086)PASVSSGR 129.98 0.0062004 0.0 6926.0 8450.0 6580.4 7437.2 9071.9 4264.4 3089.1 3981.4 3522.2 5797.1 True False 6541.080646974744 9098.087828967586 6157.024228197798 6424.240530114401 7932.206818184996 4851.782391631044 3232.7492709355233 3992.985214843751 4226.738418490682 5629.722660325328 1.1618832830029233 1.6160810004167823 1.093663862269549 1.1411291315269088 1.4089871378720125 0.8618155252697068 0.5742288680964455 0.7092685476291306 0.7507898121301821 1.0 12.45884813655397 -6.876985986324936 4.939626984831579 0.7327485085162957 1.2827901156671762 0.6825917112861899 0.17260587389653143 0.11768934317257852 4.598151443702745 0.06112091342211413 0.05390497189186598 1.327437290359458e-07 6.876985986324936 0.5500416071508805 GGSDGTPRGS(ph)PSPASVSSGR ddPTM_A459_Selumetinib_30min_R1 1 GGSDGTPRGSPSPASVSSGR 20 1 P10398;Q96II5 P10398 ARAF Serine/threonine-protein kinase A-Raf 1 GGSDGTPRGS(0.996)PS(0.003)PASVSSGR 107.63 0.0021048 3253900.0 635.28 502.97 1805.7 2112.3 998.7 749.7 561.28 575.43 345.17 300.2 True False 650.0807879603036 444.0820385755907 1560.4958580001162 1743.42645778178 908.3677613348061 742.1586986731364 518.9421977108797 560.167727139936 585.7282797806516 338.7335941956246 1.9191506219039807 1.3110067799154443 4.606852950932591 5.146895636146796 2.681658320580414 2.190980497330084 1.5320068827043514 1.6537117567867488 1.7291709172559462 1.0 8.404007264224195 -6.840407508582828 2.6045724551376788 1.5612957319196274 3.253081240886798 0.3482191856406225 1.07319939059192 0.3698016446782865 5.110358524577885 0.4669537909625011 0.4126884041159853 1.4440841172120913e-07 6.840407508582828 1.6917855089671705 GGSGS(ph)GPTIEEVD ddPTM_A459_Selumetinib_30min_R2 1 GGSGSGPTIEEVD 13 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 GGS(0.329)GS(0.66)GPT(0.011)IEEVD 100.93 0.010528 3264500.0 29352.0 24550.0 31939.0 31490.0 31293.0 24417.0 20127.0 23615.0 22418.0 27472.0 True False 27720.73334536569 26432.906059308196 29884.079512553875 27201.007676720044 27361.693577030503 27780.22011454253 21062.9453808939 23683.715740326297 26902.22641125549 26678.811979171922 1.0390542639982319 0.990782726005352 1.1201428135512292 1.019573423957401 1.0255964020583714 1.041284002309791 0.7895008742269966 0.8877350220398161 1.008374227167911 1.0 14.703406803571268 -7.198673214969431 24.99211490478631 0.9120469887502699 1.039336315032458 0.439967262630676 0.06487963309050077 191.30486080912587 76173.22301384197 0.024612545168489368 0.019064793106855975 6.328878889636706e-08 7.198673214969431 0.12728932628218803 GGSGS(ph)VLQDEEVLASLER ddPTM_A459_Selumetinib_30min_R1 1 GGSGSVLQDEEVLASLER 18 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 1 GGS(0.001)GS(0.999)VLQDEEVLASLER 107.93 0.0029019 0.0 0.0 124.22 143.48 158.61 98.797 0.0 138.22 125.41 0.0 0.0 True False 0.0 109.6762646516887 123.996204079225 130.91174097844444 89.86082879402707 0.0 127.79395411843956 122.08371941090894 0.0 0.0 0.0 GGSGSHNWGTVKDELTES(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 GGSGSHNWGT(0.001)VKDELT(0.366)ES(0.633)PK;GGSGSHNWGTVKDELT(0.041)ES(0.959)PK 91.378 0.00085436 33479000.0 3562.3 5412.8 5001.6 5354.3 5505.8 4908.7 5336.2 4377.0 2081.74 3479.4 True False 3645.29465897083 4779.066859657547 4322.410191822218 4419.272017658943 5007.80136212794 4859.322934743001 4933.68613780073 4260.9077415002685 3532.560735726087 3926.0148822260376 0.9284974123439796 1.217281901118987 1.1009663288314957 1.125638121665303 1.275543142946145 1.2377240230907582 1.2566651644996685 1.0853009653097259 0.8997828183787059 1.0 11.938849926257054 -8.051937236339374 4.844571329003327 0.9564009022461886 1.169107632439673 0.425533708721169 0.09789805248122799 0.20121961709760483 10.128958183069319 0.06870712566508083 0.025670531269612686 8.872842319091772e-09 8.051937236339374 0.2127067301934844 GGSISVQVNSIKFDS(ph)E ddPTM_A459_Selumetinib_30min_R1 4 GGSISVQVNSIKFDSE 16 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 GGSISVQVNSIKFDS(1)E;GGSISVQVNSIKFDS(1)E;GGSISVQVNS(0.005)IKFDS(0.995)E;GGSISVQVNS(0.002)IKFDS(0.998)E 229.02 1.6488999999999995e-14 483000800.0 26038.2 29098.6 38036.7 40180.4 29411.4 28778.89 27870.22 26592.77 17658.949999999997 24139.409999999996 True False 26644.83939848251 25691.722384427852 32871.52506063743 33163.647419521396 26751.14406300442 28489.400495741414 25767.946866957158 25887.44335410921 29965.94839132175 27237.93841126517 0.9782252605234849 0.9432330008427573 1.2068286727251831 1.2175535063918586 0.9821280766220023 1.045945550855591 0.9460314682369628 0.9504186022904944 1.100154789208581 1.0 14.733329892135897 GGSISVQVNSIKFDS(ph)E ddPTM_A459_Selumetinib_30min_R2 13 GGSISVQVNSIKFDSE 16 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 GGSISVQVNSIKFDS(1)E;GGSISVQVNS(0.004)IKFDS(0.995)E;GGSISVQVNS(0.002)IKFDS(0.998)E;GGSISVQVNS(0.001)IKFDS(0.999)E;GGSISVQVNS(0.012)IKFDS(0.988)E;GGSISVQVNS(0.001)IKFDS(0.999)E;GGSISVQVNS(0.012)IKFDS(0.988)E;GGSISVQVNSIKFDS(1)E;GGSISVQVNSIKFDS(1)E;GGSISVQVNS(0.003)IKFDS(0.997)E;GGSISVQVNSIKFDS(1)E;GGSISVQVNS(0.001)IKFDS(0.999)E;GGSISVQVNS(0.001)IKFDS(0.999)E 190.18 3.7880000000000006e-08 95366400.0 1072767.5 1109208.0 1051616.0 1120107.0 1043217.8 762268.7000000001 844496.4 824969.8999999999 648352.9 1047254.7 True False 1013147.376978555 1194280.68693414 983956.1714729291 967546.4943076506 912159.4534785372 867264.2942386937 883767.155937871 827370.425827881 778041.5964936246 1017017.735716514 0.9961944038908699 1.174296814099058 0.9674916541939239 0.9513565598007888 0.8968963091247355 0.8527523796108478 0.8689790992830968 0.8135260544350076 0.7650226433322475 1.0 19.955913407818656 -5.853682435888553 1.1967550028255112 0.8493237834612384 1.087665967830282 0.5644939486510658 0.07300390378954545 0.3274799970191093 0.9382864946172326 0.025612442263668725 0.05981816225960656 1.400611100817141e-06 5.853682435888553 0.23834218436904364 GGSS(ph)KDLLDNQSQEEQR ddPTM_A459_Selumetinib_30min_R2 2 GGSSKDLLDNQSQEEQR 17 1 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 GGS(0.035)S(0.935)KDLLDNQS(0.03)QEEQR;GGS(0.153)S(0.847)KDLLDNQSQEEQR 127.78 0.0050605 14390200.0 23971.0 12892.0 17997.8 23596.0 21249.7 22141.7 15960.099999999999 15889.0 17011.4 30664.0 True False 22638.787783515963 13880.774945686406 16839.841142522997 20382.184094629603 18580.122711271688 25191.518192659478 16702.27627433818 15935.234359434446 20414.155338229622 29778.65064535991 0.7602355141314479 0.46613176369189513 0.5655004769380634 0.6844562682629658 0.6239410553737373 0.8459590225450596 0.5608808966278905 0.5351227813916231 0.6855298979576344 1.0 14.86199076236965 -8.558503643145146 20.694107317858386 1.0000000026146496 0.6279439118259652 0.5218938637877619 0.10556367270830294 1150.0763664395854 668066.5934980826 0.10308580745514515 0.026616641032040166 2.7637347350650268e-09 8.558503643145146 -0.3720560907886844 GGSSGATGEPGDSS(ph)DREPGRPPGDR ddPTM_A459_Selumetinib_30min_R1 1 GGSSGATGEPGDSSDREPGRPPGDR 25 2 J3KNZ9;H3BRE6 J3KNZ9 FBRS 1 GGS(0.008)S(0.025)GAT(0.019)GEPGDS(0.203)S(0.746)DREPGRPPGDR 58.858 0.0099609 6093800.0 885.88 1429.3 1327.5 1288.6 1097.8 1230.1 1349.5 1196.4 471.36 935.19 True False 906.5192803775868 1261.9568915364564 1147.2327914355399 1063.5702000178012 998.5041838323316 1217.726310841438 1247.7061285113166 1164.6675855451044 799.8634932277077 1055.2307460220065 0.8590720880669654 1.1959061051753497 1.0871866610789738 1.0079029672204232 0.9462425043967664 1.1539905517651043 1.1824012266652586 1.1037089185807476 0.757998661660515 1.0 10.043342790459006 -8.243904714568261 24.93425166635173 0.8789993166205106 1.0727621095785393 0.3021024147379513 0.11406519858563394 803.8397159315455 1143062.802268899 0.0762422932826919 0.028673244356649617 5.702893816511002e-09 8.243904714568261 0.19376279295802878 GGSSVEAPCPSDVT(ph)PEDDR ddPTM_A459_Selumetinib_30min_R2 2 GGSSVEAPCPSDVTPEDDR 19 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 GGSSVEAPCPS(0.001)DVT(0.999)PEDDR;GGSSVEAPCPS(0.012)DVT(0.988)PEDDR 245.22 3.4412999999999995e-30 17059000.0 51050.0 44155.0 54328.0 58689.0 62707.0 55035.0 67704.0 70322.0 66703.0 46839.0 True False 48212.84536934174 47541.54651929749 50832.59562785393 50695.45695582801 54829.18605230727 62615.57169201163 70852.37015293087 70526.62537756615 80045.46383754024 45486.63636766281 1.059934284426822 1.0451761289848978 1.1175281288548222 1.1145132066056271 1.205391086936607 1.376570718175285 1.5576524406034336 1.5504911114444302 1.7597578152524347 1.0 15.473155134137015 -6.745821868799499 1.7700704222805572 1.5136346007870114 1.081154320324293 0.4714730959175306 0.18262770589790953 0.2708499842635769 1.7544745675914233 0.0720802521969965 0.06661056727548743 1.7954699097968567e-07 6.745821868799499 -0.43248028046271836 GGTLGGGTLGPPS(ph)PPGAPSPPEPGGEIELVFRPHPLLVEK ddPTM_A459_Selumetinib_30min_R1 2 GGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEK 40 1 Q06587;Q06587-2 Q06587 RING1 E3 ubiquitin-protein ligase RING1 1 GGT(0.005)LGGGT(0.035)LGPPS(0.956)PPGAPS(0.004)PPEPGGEIELVFRPHPLLVEK;GGT(0.012)LGGGT(0.058)LGPPS(0.913)PPGAPS(0.017)PPEPGGEIELVFRPHPLLVEK 82.294 1.4861e-09 197518000.0 6532.4 8359.5 5870.1 6223.1 6766.5 6241.700000000001 7477.6 6566.299999999999 4099.0 6759.4 True False 6684.592210162267 7380.765853773885 5072.972662151232 5136.352407054773 6154.471269722604 6178.914165010162 6913.558611749704 6392.140393651638 6955.703620885043 7627.0348321316005 0.8764339428477554 0.9677110458024631 0.6651303912733593 0.6734402713641819 0.8069284335499167 0.8101332039260245 0.9064543120511102 0.8380898388876461 0.911980051747196 1.0 12.896906573121694 -8.301397391206748 0.7608623764541528 0.9954969023937598 0.7976186187611347 0.3352924898951639 0.08660146769703747 0.8265711768435999 1.0649393753896519 0.09199124976868776 0.036376532136580424 4.995771991114247e-09 8.301397391206748 -0.19787828363262505 GGTMTDLDEQEDESMETTGKDEDENS(ph)TGNKGEQTK ddPTM_A459_Selumetinib_30min_R2 1 GGTMTDLDEQEDESMETTGKDEDENSTGNKGEQTK 35 2 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 GGTMTDLDEQEDES(0.024)MET(0.025)T(0.025)GKDEDENS(0.755)T(0.168)GNKGEQT(0.002)K 58.111 0.00021698 7325700.0 35519.0 21399.0 28664.0 27545.0 23585.0 26634.0 37326.0 36296.0 22623.0 26864.0 True False 33544.9961738227 23040.2344913701 26819.789447003477 23793.323482224638 20622.041447424803 30302.591740620304 39061.732960065856 36401.61535087372 27148.2321394341 26088.366518945622 1.2858220214539688 0.8831612540646445 1.028036363546437 0.9120281051305262 0.7904688640604952 1.1615365691299326 1.49728550201481 1.3953198382289866 1.0406259862885165 1.0 14.671118994506163 -6.990703187677509 23.438224907190175 1.2752739955601178 0.9736889173390412 0.2909981457521513 0.1845218673560519 100.6219743250838 253675.32366061883 0.06424083299922444 0.05655734308723008 1.0216374686127956e-07 6.990703187677509 -0.3015850782210766 GGTPAFLPS(ph)SLSPQSSLPASR ddPTM_A459_Selumetinib_30min_R2 1 GGTPAFLPSSLSPQSSLPASR 21 0 Q96JY6;Q96JY6-3;Q96JY6-5;A0A087WVI1;E5RGS7;H0YBP7;B3KPU0 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 GGTPAFLPS(0.69)S(0.285)LS(0.024)PQSSLPASR 206.45 1.3810999999999997e-17 2794800.0 18830.0 20480.0 28282.0 24602.0 30113.0 24213.0 20776.0 24676.0 20841.0 26944.0 True False 17783.503982462382 22050.750146420844 26462.36691111332 21251.165159182816 26329.935726364354 27548.12096627017 21742.125166863003 24747.8030746683 25009.782346193955 26166.05671108065 0.6796401987056585 0.8427234714768053 1.0113242206613116 0.8121653711078098 1.0062630382977922 1.052818973468182 0.8309286113278113 0.945797960614686 0.9558101406851631 1.0 14.675408902635528 -4.8783273112244245 2.8406264168173645 0.9462057583955249 0.6586836902785821 0.5653997623771212 0.07361280780460544 0.25008304288780564 3.2528694325690126 0.018825835620349573 0.15180525500281725 1.323343805398626e-05 4.8783273112244245 -0.2875220681169428 GGTPAFLPSS(ph)LSPQSSLPASR ddPTM_A459_Selumetinib_30min_R2 3 GGTPAFLPSSLSPQSSLPASR 21 0 Q96JY6;Q96JY6-3;Q96JY6-5;A0A087WVI1;E5RGS7;H0YBP7;B3KPU0 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 GGTPAFLPS(0.449)S(0.492)LS(0.058)PQSS(0.001)LPASR;GGTPAFLPS(0.191)S(0.404)LS(0.404)PQSSLPASR;GGTPAFLPS(0.103)S(0.538)LS(0.359)PQSSLPASR 233.87 2.4542e-25 34598700.0 77869.0 81679.0 92877.0 104113.0 104378.0 90535.0 81748.0 76738.0 76823.0 101801.0 True False 73541.352714305 87943.51666062039 86901.39493683176 89932.62979505719 91265.10248884058 103005.37445509709 85549.44398058897 76961.29487534029 92189.74661396553 98861.7406192371 0.7438808203625225 0.8895606744304866 0.8790194709551975 0.909680825279315 0.9231589684460976 1.0419134218141988 0.8653443025050508 0.7784740021092114 0.9325118699763891 1.0 16.59312468720693 -4.036131299732457 1.3246804683122986 0.912960809842065 1.513261993271957e-09 0.36389611930796595 0.06794994091828495 10.069940859379312 3.668883316672014 0.020662672428581916 20.046594846281096 9.201713353940966e-05 4.036131299732457 -0.912960808328803 GGTPAFLPSSLS(ph)PQSSLPASR ddPTM_A459_Selumetinib_30min_R1 2 GGTPAFLPSSLSPQSSLPASR 21 0 Q96JY6;Q96JY6-3;Q96JY6-5;A0A087WVI1;E5RGS7;H0YBP7;B3KPU0 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 GGTPAFLPS(0.01)S(0.208)LS(0.765)PQS(0.01)S(0.006)LPASR;GGTPAFLPS(0.004)S(0.044)LS(0.939)PQS(0.006)S(0.006)LPASR 246.67 9.3089e-39 74589000.0 1847.1 2138.55 2539.0 2717.2 1909.46 1666.75 2008.52 1804.52 873.02 1536.75 True False 1890.1338361690548 1888.1675718150766 2194.2177457286894 2242.6920281610833 1736.749680142544 1649.9840082879157 1857.0157193312712 1756.658267692955 1481.4511771420007 1734.0068317126115 1.090038286817038 1.0889043441369872 1.2654031723517174 1.2933582423928878 1.001581797937453 0.9515441220368724 1.0709391020663792 1.0130630604021158 0.8543514074156379 1.0 10.759893867223271 -6.361471516443928 7.263798066051735 0.984153877202964 1.182968896147722 0.6095931618048469 0.07945081758144971 0.20155575738618403 12.808222687279422 0.026525232460557126 0.03008465417423713 4.350392921001098e-07 6.361471516443928 0.19881501894475806 GGTSQVGS(ph)PTLLSPAVPSK ddPTM_A459_Selumetinib_30min_R2 1 GGTSQVGSPTLLSPAVPSK 19 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 GGT(0.025)S(0.022)QVGS(0.847)PT(0.096)LLS(0.01)PAVPSK 63.606 0.027711000000000003 7671900.0 25902.0 23446.0 27361.0 26863.0 27697.0 20335.0 29507.0 27096.0 20538.0 24458.0 True False 24462.470533921434 25244.23280922769 25600.623048404337 23204.21305874028 24217.455245678386 23135.961667249136 30879.13396701128 27174.844874015726 24646.173879666603 23751.833990484374 1.029919228288719 1.062832992995034 1.0778377391261929 0.9769440569530973 1.0196035916797226 0.9740705360486279 1.300073669232544 1.1441156453393326 1.0376535087581247 1.0 14.535751294543497 GGTTSWGTS(ph)GQPSPSYDSSR ddPTM_A459_Selumetinib_30min_R2 2 GGTTSWGTSGQPSPSYDSSR 20 0 Q99081;Q99081-3;H0YNQ5 Q99081 TCF12 Transcription factor 12 1 GGTTSWGT(0.078)S(0.854)GQPS(0.033)PS(0.033)Y(0.002)DSSR;GGTTSWGT(0.067)S(0.744)GQPS(0.188)PSYDSSR 197.94 1.3945e-15 15201900.0 28221.6 28534.6 30040.5 37203.0 34560.7 29633.6 26075.7 31572.9 27466.0 38235.0 True False 26653.15645201596 30723.11206679982 28107.726935623377 32135.88722124537 30218.87588942186 33715.3594129626 27288.271718019325 31664.771911825035 32959.9674641602 37131.05620353955 0.7178130432356304 0.8274235965275643 0.756987002512037 0.8654719393137541 0.8138436925621636 0.9080097056261129 0.7349177348587796 0.8527840344279397 0.8876657664539654 1.0 15.180338733199854 -14.522878745279895 0.11259234354740356 1.5926122946677608 0.7189134807236686 0.5710391502091088 0.05356679553190287 123.81685755934934 0.9175532875599337 16.777159783907177 0.6169507521478964 3.0000000000030567e-15 14.522878745279895 -0.8736988139440922 GGTTSWGTSGQPS(ph)PSYDSSR ddPTM_A459_Selumetinib_30min_R1 2 GGTTSWGTSGQPSPSYDSSR 20 0 Q99081;Q99081-3;H0YNQ5 Q99081 TCF12 Transcription factor 12 1 GGTTSWGT(0.073)S(0.022)GQPS(0.902)PS(0.002)YDSSR;GGTTSWGT(0.273)S(0.027)GQPS(0.632)PS(0.066)YDS(0.002)SR 332.57 4.705199999999998e-155 18307000.0 3173.37 3345.6 3612.3 3738.85 3514.49 3022.7 3235.6 3087.41 1909.94 2854.77 True False 3247.3033466968727 2953.895596672757 3121.769500943578 3085.9300344067665 3196.6050000336054 2992.2943823920123 2991.536087003497 3005.521857478944 3241.028683501629 3221.207537314603 1.0081012505651916 0.9170149897064088 0.9691301987782126 0.9580041020825959 0.99236232468849 0.9289356080690699 0.9287002008872194 0.9330419796498217 1.0061533278925425 1.0 11.65338589894041 -8.274301308396529 24.378033464525934 1.003076683061997 0.9533339797099187 0.3279589819638462 0.0278313969313966 725.0708458438152 1374253.915655079 0.02565720643420788 0.006811543838472402 5.3173921685699895e-09 8.274301308396529 -0.04974270335207831 GGTTSWGTSGQPS(ph)PSYDSSR ddPTM_A459_Selumetinib_30min_R2 2 GGTTSWGTSGQPSPSYDSSR 20 0 Q99081;Q99081-3;H0YNQ5 Q99081 TCF12 Transcription factor 12 1 GGTTSWGT(0.005)S(0.141)GQPS(0.853)PS(0.002)YDSSR;GGTTSWGT(0.001)S(0.002)GQPS(0.498)PS(0.498)YDSSR 246.9 8.6602e-38 16071700.0 37062.0 31678.0 35041.0 43114.0 46273.0 33005.0 37391.0 38247.0 31788.0 41871.0 True False 35002.242410941086 34107.60073917578 32786.500209756116 37241.79882420161 40459.77205413135 37551.13916044053 39129.75558886091 38358.29243786827 38146.48823093004 40662.07543607699 0.8608080634242717 0.8388061940614614 0.8063164474056 0.9158853409425142 0.995024764973847 0.923492929412149 0.9623157492385018 0.9433432019024608 0.9381343136529862 1.0 15.311396233318433 -5.926732801454672 4.779871312022871 0.9559082055268748 0.8366164619584832 0.823499580480388 0.02580132594665233 0.07942686617610689 3.4115603520939444 0.007119000104100271 0.010718699305571495 1.183769642905343e-06 5.926732801454672 -0.11929174356839167 GGTVS(ph)PPPGTSR ddPTM_A459_Selumetinib_30min_R2 2 GGTVSPPPGTSR 12 0 Q16584;Q16584-2;E9PID4 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 GGT(0.001)VS(0.973)PPPGT(0.023)S(0.003)R;GGT(0.003)VS(0.996)PPPGT(0.002)SR 141.34 0.00099971 13929500.0 117056.0 96706.0 122561.0 126460.0 135698.0 100666.0 101574.0 114625.0 99332.0 103016.0 True False 110550.49613229501 104123.03924119976 114675.55869432737 109235.92984433204 118650.40408448812 114531.8277450358 106297.39226506266 114958.53977280967 119201.17556797339 100041.66041228772 1.1050445951886314 1.0407967921772991 1.146278042784686 1.0919044065657575 1.186009944212349 1.1448413318314767 1.0625312677437986 1.1491066751496037 1.1915153654660093 1.0 16.61024138197731 -5.26977388508394 24.955719161483955 1.126819811996735 1.0729206926158266 0.0989090152601706 0.05691076128909321 1053.000445590476 3152971.13695599 0.014197201713085129 0.03040980951902486 5.3731147415004045e-06 5.26977388508394 -0.05389911938090841 GGVDHAAAFGR ddPTM_A459_Selumetinib_30min_R1 2 GGVDHAAAFGR 11 0 I3L3Q4;F6TLX2;Q9HC38-2;Q9HC38 I3L3Q4 GLOD4 Glyoxalase domain-containing protein 4 0 ; 102.95 0.019346 6649500.0 9654.7 11511.6 12837.6 12949.6 12497.9 10643.0 11956.9 10925.400000000001 6448.2 9171.6 False True 9879.635725224058 10163.816520402353 11094.324431889176 10688.195454097873 11367.467151683457 10535.941083070817 11054.98140644458 10635.622901299295 10942.124442105622 10348.864198949346 0.9546589398889854 0.9821190349984708 1.0720330481305873 1.032789226781329 1.098426545479022 1.0180770450288124 1.0682313724405545 1.0277091956022635 1.057326121181154 1.0 13.337184818340722 -5.117220940388935 4.339607712533932 1.048735265285405 0.960229947189333 0.5707507634641862 0.027539362818247995 0.13651059712017596 4.107875808814064 0.006525193591399716 0.01975242127996087 7.634472931365654e-06 5.117220940388935 -0.08850531809607198 GGVDHAAAFGR ddPTM_A459_Selumetinib_30min_R2 1 GGVDHAAAFGR 11 0 I3L3Q4;F6TLX2;Q9HC38-2;Q9HC38 I3L3Q4 GLOD4 Glyoxalase domain-containing protein 4 0 97.597 0.026811 3514500.0 46528.0 38938.0 47590.0 48796.0 46061.0 33394.0 37073.0 38247.0 36656.0 42223.0 False True 43942.16002634145 41924.41939459643 44528.11121207426 42149.9006222049 40274.405389435415 37993.7203794501 38796.96795875586 38358.29243786827 43988.22425421455 41003.91228147114 1.0716577414540527 1.0224492508618805 1.0859478702034888 1.0279482682741865 0.9822088466332669 0.926587690429206 0.9461772255397065 0.9354788434468881 1.0727811520095354 1.0 15.323473946836359 -6.180829079001409 3.0971320538935765 0.9691622530810229 1.0561967419110638 0.4381549276347072 0.041977103231267 0.23370571187731107 4.368224211973799 0.013103037742587274 0.01726579513818858 6.594333708733661e-07 6.180829079001409 0.08703448883004095 GGVGAPGS(ph)PSTPPTR ddPTM_A459_Selumetinib_30min_R1 2 GGVGAPGSPSTPPTR 15 0 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 GGVGAPGS(0.747)PS(0.004)T(0.248)PPT(0.001)R;GGVGAPGS(0.708)PS(0.035)T(0.257)PPT(0.001)R 111.07 0.003344300000000001 10527700.0 3922.2 3936.7 3786.9 3964.8999999999996 4023.0 3587.1 3843.0 3505.5 2386.3 3391.2 True False 4013.5796287273342 3475.78933387782 3272.6597799527276 3272.5046453907994 3659.1203603183385 3551.017030826207 3553.1194159829492 3412.522752531228 4049.376811543783 3826.4935530852836 1.0488923012796412 0.9083484097537046 0.8552633722103092 0.8552228299854823 0.9562593820047095 0.9280081049563088 0.9285575335983739 0.8918145830350941 1.0582473889911013 1.0 11.901807253658601 -8.260609505378447 24.995269965062786 1.0291237013613088 0.9182919716647692 0.3874203356306367 0.05398554030540767 73.58405231273964 2216492.046997327 0.04285369526460322 0.013951910782730984 5.487701682587796e-09 8.260609505378447 -0.11083172969653965 GGVGAPGS(ph)PSTPPTR ddPTM_A459_Selumetinib_30min_R2 1 GGVGAPGSPSTPPTR 15 0 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 GGVGAPGS(0.815)PS(0.021)T(0.164)PPTR 99.238 0.0083644 7977600.0 31818.0 23066.0 28726.0 37954.0 36344.0 24770.0 29972.0 29363.0 27738.0 32515.0 True False 30049.682937545822 24835.088031120267 26877.80043450399 32784.59972569809 31778.14180051758 28181.84266032758 31365.757388391317 29448.44146869366 33286.37506447522 31576.207465884334 0.9516558620921209 0.7865126949761991 0.8512042006166634 1.0382690752560875 1.006395142128814 0.8925024542854266 0.993335169281479 0.9326148968494852 1.0541600064047778 1.0 14.946550282896752 -5.74639756614353 24.947030258427166 0.9823615765422301 0.855463032741267 0.4891785978295887 0.05819326390178759 191.75711060075272 318028.84221945284 0.015478777232259006 0.02667380090836174 1.7930914258264439e-06 5.74639756614353 -0.1268985438009631 GGVGAPGSPST(ph)PPTR ddPTM_A459_Selumetinib_30min_R2 1 GGVGAPGSPSTPPTR 15 0 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 GGVGAPGS(0.436)PS(0.025)T(0.534)PPT(0.006)R 121.42 0.0039228 7914300.0 23387.0 19154.0 31325.0 27190.0 26990.0 21997.0 24068.0 21872.0 17608.0 23812.0 True False 22087.244165578755 20623.050210182853 29309.583604081225 23486.675094633792 23599.2749063386 25026.8870811153 25187.20968983724 21935.643898895494 21130.092008626427 23124.485688993955 0.95514531491142 0.8918274113226374 1.2674696422775384 1.01566259291173 1.0205318822537368 1.082267835821611 1.089200859581713 0.9485894818986488 0.9137540308056773 1.0 14.497133658597246 -7.777331044397494 24.326150543780855 0.9483787188058241 1.0478490714945816 0.16411728337264175 0.09471559282984687 324.51422059310937 496740.09029979404 0.052686824009531286 0.02545596778193685 1.669817297656532e-08 7.777331044397494 0.09947035268875748 GGVT(ph)GSPEASISGSK ddPTM_A459_Selumetinib_30min_R1 3 GGVTGSPEASISGSK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GGVT(0.827)GS(0.173)PEASISGSK;GGVT(0.801)GS(0.199)PEASISGSK;GGVT(0.759)GS(0.241)PEASISGSK 247.9 1.5707999999999999e-27 2122000000.0 17468.9 18022.4 17710.0 16914.4 16690.1 14932.800000000001 16166.499999999998 15614.400000000001 9090.0 14449.8 True False 17875.891381437705 15912.329029613546 15305.079274066587 13960.61756261145 15180.483401876474 14782.589589897587 14947.047889276177 15200.25538928074 15425.06609266773 16304.572582971141 1.0963728911304111 0.975942727025714 0.938698588765924 0.8562394071704909 0.9310568139474756 0.9066529965548961 0.9167396332049333 0.9322694791249067 0.9460576788610829 1.0 13.992989001530631 -4.759900104246285 2.0011796720337225 0.9223340822121612 1.1536365654868013 0.6874204361503407 0.0340955733486364 0.42480616706013746 1.7800249644183914 0.008891061596922897 0.18639814949370404 1.738200601018743e-05 4.759900104246285 0.2313024832746401 GGVTGS(ph)PEASISGSK ddPTM_A459_Selumetinib_30min_R1 3 GGVTGSPEASISGSK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GGVTGS(0.995)PEAS(0.005)ISGSK;GGVT(0.001)GS(0.999)PEASISGSK;GGVT(0.052)GS(0.941)PEAS(0.006)ISGSK 212.35 4.2325e-14 16338500.0 6893.5199999999995 15276.3 7123.7699999999995 8161.8 6593.91 6259.07 6740.6 6621.700000000001 3835.0299999999997 7301.700000000001 True False 7054.1256035450715 13487.7436942408 6156.401162067607 6736.494845960958 5997.492004749368 6196.1094385808565 6232.151115111805 6446.071005687078 6507.765810491037 8238.944319580924 0.8561928967986862 1.6370718348205633 0.7472317961217578 0.8176405355660434 0.7279442331580694 0.7520513791864082 0.756425929508989 0.7823904077573568 0.7898786007115601 1.0 13.008243777109895 -5.29649304888656 24.943876523425605 0.7841835503757082 1.2466325338529616 0.47337741399817634 0.1894595110116217 373.5866870836171 265840.24454994017 0.044607403483497676 0.09286363282493876 5.052507316812779e-06 5.29649304888656 0.4624489834772534 GGVTGS(ph)PEASISGSK ddPTM_A459_Selumetinib_30min_R2 6 GGVTGSPEASISGSK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GGVT(0.054)GS(0.502)PEAS(0.441)IS(0.003)GSK;GGVT(0.001)GS(0.838)PEAS(0.155)IS(0.006)GSK;GGVT(0.002)GS(0.998)PEASISGSK;GGVT(0.007)GS(0.983)PEAS(0.009)IS(0.001)GSK;GGVTGS(1)PEASISGSK;GGVT(0.015)GS(0.982)PEAS(0.003)ISGSK 255.91 1.8929e-39 1460907000.0 192368.0 174349.0 209559.0 223488.0 204183.0 166179.0 235242.0 213011.0 173102.0 175932.0 True False 181676.95667011806 187721.00767960615 196076.20209058796 193048.5488616958 178531.70612081978 189068.6488272338 246181.21912318005 213630.8267441304 207727.23687399173 170852.38603376813 1.0633562743116185 1.0987321396992609 1.147635140733911 1.129914268938221 1.0449471047219316 1.1066198911021665 1.440900094158027 1.250382459990388 1.2158287144607713 1.0 17.38239087025812 -7.0513504596013865 24.987007445331333 1.2513741025628515 1.0990799210377369 0.2559162620036124 0.10386940211977495 399.19184296849915 194244.45788063091 0.03791733354142944 0.029370923400919503 8.884838548496923e-08 7.0513504596013865 -0.15229418152511465 GGVTGS(ph)PEASISGSKGDLK ddPTM_A459_Selumetinib_30min_R1 2 GGVTGSPEASISGSKGDLK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GGVT(0.052)GS(0.948)PEASISGSKGDLK;GGVTGS(0.999)PEASISGSKGDLK 222.51 8.6324e-19 39642000.0 2367.16 1231.1 12976.900000000001 10815.2 5698.7 3062.4 2233.67 2550.21 2383.2799999999997 1301.2 True False 2422.3102223084484 1086.9622396771367 11214.708257009308 8926.528346447718 5183.2535911872 3031.5950364367272 2065.1824735619666 2482.570146550467 4044.252092115859 1468.2216947613158 1.649825929525061 0.7403256902928688 7.638293519993551 6.079823216274485 3.5302935583102286 2.0648074110698684 1.4065876297364595 1.6908687260298594 2.754524133886552 1.0 10.519854109644639 -6.724233829668348 3.8535347994976545 1.776172413104993 4.123490652276972 0.24680194925109455 1.8852625367518507 0.35701847833012923 11.195672970098922 0.7312920019894924 0.7004810519538809 1.886975104164284e-07 6.724233829668348 2.3473182391719796 GGVTGSPEAS(ph)ISGSK ddPTM_A459_Selumetinib_30min_R1 2 GGVTGSPEASISGSK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GGVT(0.107)GS(0.327)PEAS(0.556)IS(0.01)GSK;GGVT(0.052)GS(0.239)PEAS(0.707)IS(0.001)GSK 104.95 0.0048502 246560000.0 3486.0 3576.1 3244.3 3770.0 3979.8 3496.5 3872.7 3452.0 2173.9 3065.0 True False 3567.2170174247867 3157.4085495162153 2803.7418796642737 3111.6402716646858 3619.827792690761 3461.328384567992 3580.579121071344 3360.4417463237214 3688.949524626005 3458.4226056282123 1.0314578130560226 0.9129620377734842 0.8106996163804516 0.8997281785634944 1.04667017466283 1.000840203546857 1.0353214541347073 0.9716689165907494 1.066656665562686 1.0 11.755898456069012 -6.254634091741694 24.78690303522391 1.0185651415007353 0.9063003208152747 0.46423136597553405 0.05579697269495566 435.70126613623347 1586953.4853996295 0.01714175333694231 0.021620861949973383 5.563728233726862e-07 6.254634091741694 -0.11226482068546062 GGVTGSPEASISGS(ph)KGDLK ddPTM_A459_Selumetinib_30min_R2 3 GGVTGSPEASISGSKGDLK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GGVTGSPEAS(0.005)IS(0.104)GS(0.891)KGDLK;GGVTGSPEASIS(0.403)GS(0.596)KGDLK;GGVTGSPEAS(0.011)IS(0.316)GS(0.673)KGDLK 169.62 1.4825e-06 50370000.0 264390.0 237961.0 199034.0 222405.0 186867.0 220974.0 251692.0 211828.0 139212.0 179256.0 True False 249696.26223702767 256211.8435347873 186228.36913183433 192113.05532997494 163391.09684782405 251411.16269774863 263396.17671823665 212444.38440998664 167058.28990827492 174080.41351697873 1.4343730991463541 1.4718016711845527 1.069783586616255 1.1035879996415416 0.9385955234526594 1.444224296222892 1.513071869469948 1.2203807431171234 0.9596616100178386 1.0 17.409394363172318 -5.249450729290789 24.232559346743653 1.1774206196752615 1.4530874548463983 0.28826383342923023 0.18421820857146654 735.9747260039071 1487608.1898358052 0.051004155887490826 0.1324978501042714 5.630529921331476e-06 5.249450729290789 0.2756668351711369 GGYFDEFGIIR ddPTM_A459_Selumetinib_30min_R1 1 GGYFDEFGIIR 11 0 P11413-3;P11413;P11413-2;E7EUI8;E7EM57 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 163.16 0.0087907 12571000.0 1896.6 2262.2 1954.5 2833.8 2226.2 2077.5 1784.0 1982.4 1469.7 1749.3 False True 1940.7870898588208 1997.340572331751 1689.089635300009 2338.9300270141594 2024.840603067533 2056.602236219076 1649.43144369336 1929.8203122572831 2493.973557359051 1973.8396946249366 0.98325466609263 1.0119061734196606 0.8557380013684267 1.1849645304952672 1.0258384247623957 1.0419297179094709 0.8356461004330853 0.9776986031401006 1.2635137312064995 1.0 10.946789110747813 -2.490124958033053 0.23897297266306242 1.0417443285615244 0.7790583436127652 0.03000694863931397 0.12124963425904182 178.5235748180642 3.563143768294869 0.17657397229775482 16.886035693712678 0.0032350056385126746 2.490124958033053 -0.2626859849487593 GGYFDEFGIIR ddPTM_A459_Selumetinib_30min_R2 1 GGYFDEFGIIR 11 0 P11413-3;P11413;P11413-2;E7EUI8;E7EM57 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 119.62 0.045214 0.0 9238.7 8869.7 8560.9 9301.9 7922.9 6576.8 6090.2 7876.9 6633.7 7939.5 False True 8725.250039446379 9549.977469419387 8010.101014403158 8034.96517332748 6927.554470375319 7482.694501753835 6373.40636750236 7899.820474909004 7960.6253610645745 7710.266005701641 1.131640598780142 1.2386054466029193 1.0388877645051147 1.04211257658111 0.8984844965468745 0.9704846105465725 0.8266130329082433 1.0245846860623473 1.0324709102354959 1.0 12.912564918925165 -5.584656468099524 1.8319376679291934 0.9569577775478357 1.1864614238391986 0.6062768120769894 0.06766512010797161 0.2310957662809748 1.5328443790896618 0.020486480360125053 0.0519744286750454 2.6022171327806283e-06 5.584656468099524 0.22950364629136288 GGYLS(ph)DGDSPELTTK ddPTM_A459_Selumetinib_30min_R1 2 GGYLSDGDSPELTTK 15 0 Q5VT97-2;Q5VT97 Q5VT97-2 SYDE2 Rho GTPase-activating protein SYDE2 1 GGYLS(0.999)DGDS(0.001)PELTTK;GGYLS(1)DGDSPELTTK 200.55 1.8581e-05 9301300.0 3237.5 3534.1 4076.5 4242.1 3872.9 3218.2 3305.92 3023.8799999999997 1871.21 2576.87 True False 3312.927450921613 3120.325929041484 3522.9336906116578 3501.296869079245 3522.5968788160326 3185.827829891809 3056.5517927885403 2943.676879453467 3175.3067022289097 2907.636365339371 1.1393885048397163 1.0731486117856723 1.2116142625697526 1.2041728844832988 1.2114984255965877 1.0956761539608713 1.0512152857985693 1.0123951242816052 1.0920577071054403 1.0 11.50563113895232 -7.012983026035626 3.52589129941366 1.041351662082313 1.1669681103429104 0.6430574374850211 0.04523238973171279 0.16847905694056087 4.450037038593661 0.01900843153737511 0.015380987872788689 9.705478993957292e-08 7.012983026035626 0.12561644826059748 GGYLS(ph)DGDSPELTTK ddPTM_A459_Selumetinib_30min_R2 2 GGYLSDGDSPELTTK 15 0 Q5VT97-2;Q5VT97 Q5VT97-2 SYDE2 Rho GTPase-activating protein SYDE2 1 GGYLS(1)DGDSPELTTK;GGYLS(0.999)DGDS(0.001)PELTTK 190.41 2.7402e-05 6410900.0 44574.0 44625.0 50633.0 56836.0 56686.0 43861.0 42820.0 42784.0 32919.0 46348.0 True False 42096.75552385971 48047.594008009335 47375.32790504215 49094.83875243127 49564.59790073026 49902.454619484386 44811.21484622031 42908.494356727526 39503.7198337104 45009.812813434044 0.935279506678933 1.067491531394874 1.0525555416418455 1.0907585631588756 1.1011953794648253 1.1087016697076786 0.9955876740026243 0.9533142147154333 0.8776690540228097 1.0 15.457951944413061 -7.5676333570806635 3.1518259471927483 0.9364520324289057 1.0625429363057775 0.48271245709028254 0.05364437515362216 0.20791802205189372 4.231327348519503 0.028397652072355284 0.015545616111331411 2.7062420813218763e-08 7.5676333570806635 0.12609090387687172 GHAVGDIPGVR ddPTM_A459_Selumetinib_30min_R1 1 GHAVGDIPGVR 11 0 D6RD47;P62266 D6RD47 RPS23 40S ribosomal protein S23 0 108.47 0.013984 4262600.0 1731.9 2166.9 1940.9 1871.7 1897.3 1711.6 2011.3 2164.0 1217.2 1903.0 False True 1772.249900309233 1913.1983406355198 1677.336440600556 1544.8427311604225 1725.689549995522 1694.3828580084587 1859.5860216930803 2106.6036903373506 2065.499499229391 2147.26858678972 0.8253508253286751 0.8909916311381673 0.7811488748635134 0.719445504239432 0.803667301152819 0.789087526559335 0.8660239492783992 0.9810620354144121 0.9619194878258904 1.0 11.06828694376489 -7.616789732010649 2.7510396611576113 0.9818934303005545 0.801394937135822 0.7915674541823893 0.04108415069619144 0.13512597998489845 2.0551994286052917 0.025730274877309642 0.013175436547232614 2.4166305869631377e-08 7.616789732010649 -0.18049849316473254 GHDDLGDHYLDCGDLSNALK ddPTM_A459_Selumetinib_30min_R1 2 GHDDLGDHYLDCGDLSNALK 20 0 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QLT0;J3KSA5;J3KRJ4;Q13098-6 C9JFE4 GPS1 COP9 signalosome complex subunit 1 0 ; 117.07 0.00014905 11489900.0 6393.3 6884.7 7023.700000000001 7229.7 6059.1 6414.1 6476.7 5974.1 3224.5 5147.6 False True 6542.251450803754 6078.636123389802 6069.920118422452 5967.168613276967 5511.055474820987 6349.579977536838 5988.157304578911 5815.647461388337 5471.7409918379635 5808.344601870077 1.1263538751983457 1.04653503537526 1.0450344348488134 1.0273441096032345 0.9488168923459924 1.0931823803106486 1.0309576505930693 1.0012573047948823 0.9420482713915185 1.0 12.503911333839577 -1.5228787467364377 0.5978941642092073 1.0050090258812672 8.221225694410169 0.4490604789699477 0.040442808890869375 171.2088778619683 1.336469421787625 0.01895716394557487 1613.0016983989374 0.029999999899416162 1.5228787467364377 7.216216668528902 GHDGGHSHGGDMSNRPVCR ddPTM_A459_Selumetinib_30min_R2 5 GHDGGHSHGGDMSNRPVCR 19 1 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 0 ;;;; 63.681 0.011415 3075900.0 951.6300000000001 1597.6699999999998 1008.9100000000001 542.95 0.0 0.0 1474.4299999999998 1895.56 0.0 1310.0 False True 898.7422142767222 1720.2061516812607 943.9978290181515 468.99927335900804 0.0 0.0 1542.9939165276191 1901.0757657731494 0.0 1272.17689621124 0.7064600976116843 1.3521752806581602 0.7420334639227754 0.36865885141898735 0.0 0.0 1.212876857866951 1.4943486015465912 0.0 1.0 10.313083575993945 -7.291987246535661 24.99709997740864 0.9680020522487586 0.5441293746969585 0.12476633593002362 0.5115130020091394 1598.48144683729 1308019.3716441507 0.2307556139136755 0.15559529268083264 5.1051999165312915e-08 7.291987246535661 -0.4238726775518 GHEDDSYEAR ddPTM_A459_Selumetinib_30min_R2 2 GHEDDSYEAR 10 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 ; 167.93 0.00039465 8231300.0 10363.900000000001 9419.3 8109.2 10729.800000000001 18115.8 11324.900000000001 12445.0 12107.6 9010.0 15105.0 False True 9787.91592797886 10141.73002217685 7587.462900629387 9268.382730062587 15839.931246693162 12884.80217779346 13023.717159299676 12142.831111478921 10812.251760434123 14668.879402496792 0.6672572361807582 0.6913772854694424 0.5172489794508723 0.6318398615019641 1.0798323997398904 0.8783767201467575 0.8878467674281177 0.8277954149252934 0.7370877804472077 1.0 13.840471043184436 -6.178537865811378 10.069100826380861 0.8912480423210616 0.623074334399882 0.6595902143208778 0.09655653015488529 0.3447763543345445 40.311309216401746 0.02927480529303704 0.03781975315706558 6.629215455166146e-07 6.178537865811378 -0.26817370792117956 GHHDDS(ph)DEEASPEK ddPTM_A459_Selumetinib_30min_R1 1 GHHDDSDEEASPEK 14 0 Q5VT06;H0Y6Q4 Q5VT06 CEP350 Centrosome-associated protein 350 1 GHHDDS(1)DEEASPEK 193.64 7.7115e-05 4362800.0 3441.3 4505.5 3698.5 3871.7 3735.4 3861.0 3719.2 3737.3 2529.4 3454.7 True False 3521.4755943958453 3977.993965449877 3196.2640144062852 3195.5802758101204 3397.5337295384347 3822.1618455075095 3438.657749654902 3638.174663538715 4292.207059933308 3898.144396627664 0.9033722807811636 1.0204839946132556 0.8199450018248209 0.8197696007809918 0.8715771874632674 0.9805080203837785 0.8821268274796927 0.9333093629589884 1.101089806638911 1.0 11.928571817135843 -8.118352597873809 4.997761902825892 1.0482521000541565 0.9006642695518216 0.4665889225432662 0.06345831932764263 0.20678081955420613 7.423650131403388 0.04729307947291314 0.017058648569784746 7.61460539380883e-09 8.118352597873809 -0.14758783050233493 GHHDDS(ph)DEEASPEK ddPTM_A459_Selumetinib_30min_R2 1 GHHDDSDEEASPEK 14 0 Q5VT06;H0Y6Q4 Q5VT06 CEP350 Centrosome-associated protein 350 1 GHHDDS(1)DEEASPEK 162.26 0.00018323 3774800.0 38216.0 37018.0 38741.0 36619.0 43834.0 34930.0 32579.0 43598.0 32701.0 42420.0 True False 36092.107710769116 39857.161568369505 36248.4462380115 31631.42902870157 38327.18103906801 39741.29043703039 34093.98805406381 43724.862961962535 39242.113742281465 41195.22437960368 0.8761235860300063 0.9675189823241582 0.8799186503753722 0.767842134739354 0.9303792275991176 0.9647062501911471 0.8276199138981802 1.061406112491314 0.9525889064391351 1.0 15.33018947998705 -7.7634731965853 24.99999743629048 1.0052481308939822 0.8904881340211118 0.42802203301964836 0.061887134003039614 54.739611872218155 672832.48665309 0.03251583147798419 0.016843165001877484 1.7239584855363447e-08 7.7634731965853 -0.11475999687287042 GHLENNPALEK ddPTM_A459_Selumetinib_30min_R1 1 GHLENNPALEK 11 0 F8VWS0;P05388-2;Q8NHW5;P05388;F8VWV4;F8VS58;F8VQY6;F8VPE8;F8VRK7;G3V210;F8VW21;F8VZS0;F8VU65 F8VWS0 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 125.72 0.0046306 7998900.0 11701.0 15264.0 14898.0 15648.0 14446.0 12968.0 13887.0 11521.0 7905.6 10574.0 False True 11973.61053381739 13476.883783958912 12874.933428856244 12915.37054933925 13139.361850648442 12837.55369400191 12839.492409512166 11215.425654517845 13415.225797821127 11931.275899482134 1.0035482068046966 1.1295425482989514 1.079091082741207 1.0824802525855453 1.1012537101098083 1.0759581625766539 1.0761206527852945 0.9400022050453665 1.1243747869750798 1.0 13.542460708871811 -7.562780587337268 24.999975398008523 1.0209253106565357 1.0816696280940867 0.2025134904410213 0.051484413048530756 220.5259239238083 138165.32945636622 0.02225058942914357 0.012846401971023798 2.7366509778630178e-08 7.562780587337268 0.06074431743755104 GHLS(ph)EGLVTK ddPTM_A459_Selumetinib_30min_R2 1 GHLSEGLVTK 10 0 Q16659 Q16659 MAPK6 Mitogen-activated protein kinase 6 1 GHLS(1)EGLVTK 82.705 0.031106 0.0 38682.0 46673.0 46133.0 53983.0 53075.0 44054.0 38716.0 40184.0 32133.0 53900.0 True False 36532.20929631492 50252.6690226514 43164.8530058126 46630.42227413079 46407.24400347985 50122.03861760479 40516.37071429858 40300.92878718067 38560.497871035484 52343.76695098161 0.6979285485992296 0.9600506793810146 0.824641700820562 0.8908495698790422 0.8865858669846758 0.9575550545405453 0.7740438465623034 0.7699279424218989 0.736677929716947 1.0 15.675730132096364 -10.320624804966391 6.405170408205372 1.0000000031885359 0.8399540610972853 0.2514871439861732 0.0856373499612516 3.934695908598641e-09 7.803026850387322e-10 0.08385204936055728 0.020337108747670436 4.7794199828191386e-11 10.320624804966391 -0.16004594209125056 GHLSRPEAQSLS(ph)PYTTSANR ddPTM_A459_Selumetinib_30min_R2 3 GHLSRPEAQSLSPYTTSANR 20 1 O94776;O94776-2 O94776 MTA2 Metastasis-associated protein MTA2 1 GHLSRPEAQS(0.007)LS(0.984)PY(0.006)T(0.002)T(0.001)SANR;GHLSRPEAQS(0.003)LS(0.554)PY(0.029)T(0.322)T(0.083)S(0.009)ANR;GHLS(0.002)RPEAQS(0.032)LS(0.943)PY(0.007)T(0.008)T(0.004)S(0.002)ANR 79.025 0.0025615 11221600.0 18103.6 22264.5 39487.1 47089.9 59728.1 34722.0 20740.7 28512.5 36793.2 40532.7 True False 17097.474386452774 23972.11555834898 36946.54297630378 40676.17438539156 52224.52210201119 39504.64032506637 21705.18364691737 28595.466654501513 44152.86808790284 39362.41563439798 0.43436039457679154 0.6090102746997128 0.938624888255511 1.0333759686701118 1.3267611060021758 1.003613210428684 0.5514189944163302 0.7264662545129101 1.1217011805880783 1.0 15.26453113978016 -5.134928034873159 2.782144600807408 0.9576015470225828 0.4508293720794255 0.4528917660609604 0.19818753356532684 0.2977354723819866 4.243882454613642 0.05948564734094266 0.23189875906823465 7.329459764968097e-06 5.134928034873159 -0.5067721749431573 GHNSSNS(ph)PSLQAGGAEGAGDR ddPTM_A459_Selumetinib_30min_R1 1 GHNSSNSPSLQAGGAEGAGDR 21 0 Q8IWZ3-6;H7C0V5 Q8IWZ3-6 ANKHD1;ANKHD1-EIF4EBP3 Ankyrin repeat and KH domain-containing protein 1 1 GHNS(0.062)S(0.158)NS(0.769)PS(0.011)LQAGGAEGAGDR 66.556 0.0060886 1389600.0 634.2 784.78 896.32 1012.0 791.32 607.38 697.38 748.82 388.49 564.23 True False 648.9756260616176 692.8975927656757 774.6046671333357 835.2731975927484 719.7452457188936 601.2703086569157 644.7760651361408 728.9588610898402 659.2391558130348 636.6544165656139 1.019353057444366 1.0883417671135645 1.216679955370269 1.3119726744354796 1.1305116669126511 0.9444217977791229 1.0127567615321644 1.1449835925464178 1.0354740949874386 1.0 9.314366663044783 -6.542093262891634 22.143242274335115 1.035865492899251 1.1660342523077307 0.35072204489485126 0.0857343074965356 80.89294128476566 93220.62225467265 0.030915033812306595 0.03092390749770252 2.8701641603020647e-07 6.542093262891634 0.13016875940847972 GHNSSNS(ph)PSLQAGGAEGAGDR ddPTM_A459_Selumetinib_30min_R2 1 GHNSSNSPSLQAGGAEGAGDR 21 0 Q8IWZ3-6;H7C0V5 Q8IWZ3-6 ANKHD1;ANKHD1-EIF4EBP3 Ankyrin repeat and KH domain-containing protein 1 1 GHNS(0.004)S(0.034)NS(0.959)PS(0.004)LQAGGAEGAGDR 77.062 0.0017767 3285000.0 7065.0 5419.7 11201.0 13710.0 14696.0 7364.2 7199.6 7772.7 10149.0 9712.7 True False 6672.355583435832 5835.373562917824 10480.3398547267 11842.674348930834 12849.757096093072 8378.551704448295 7534.395665736757 7795.317270160247 12179.083586753153 9432.269114374743 0.70739665106323 0.6186606310908512 1.1111154407961814 1.2555488192001054 1.3623187528131582 0.8882859047860936 0.7987893023805233 0.826451957173297 1.2912145994851096 1.0 13.203389165451688 -5.261015044622431 24.992512987329423 1.0618774722478834 0.6630286117631409 0.43003641406958315 0.1858316237200311 37.57327793216691 2212815.737650454 0.05335196674485201 0.12471754048670408 5.482579721005495e-06 5.261015044622431 -0.39884886048474255 GHPEFSTNR ddPTM_A459_Selumetinib_30min_R1 2 GHPEFSTNR 9 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 ; 141.2 0.0031298000000000003 4940100.0 148.35 156.03 294.46000000000004 459.36 322.31 297.76 258.09000000000003 298.89 174.1 122.61 False True 151.80626636114943 137.7619350636209 254.47394935300113 379.14139925514337 293.15711740845234 294.7648047444489 238.62206351054905 290.96246626845226 295.43498423910364 138.34818782253683 1.0972768689668393 0.9957624832811839 1.8393732029177146 2.740486920880228 2.1189805376019333 2.1306011259254953 1.7247935608425633 2.103117293026477 2.135445276797312 1.0 7.112159936457959 -5.329029694885121 4.477897952653948 2.0535572746070927 1.0415979788630267 0.4399142010029753 0.4157759978411856 0.16453849978058047 6.442900865942933 0.1057698474753661 0.23886212499259157 4.687813281262055e-06 5.329029694885121 -1.011959295744066 GHPEFSTNR ddPTM_A459_Selumetinib_30min_R2 3 GHPEFSTNR 9 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 ;; 117.89 0.010381 2199100.0 1982.2 1682.3400000000001 7661.62 7570.62 7451.48 5524.58 2411.34 5116.16 9626.5 5097.4 False True 1872.0372593753027 1811.3700684242992 7168.679710541131 6539.488495952065 6515.358465323597 6285.540747855975 2523.4720879795623 5131.0471785741165 11552.068986883358 4950.224817364256 0.3781721696373515 0.3659167280787789 1.4481523516659371 1.321048788130397 1.3161742558578775 1.2697485426940078 0.5097691884877228 1.036528110920453 2.3336453217965665 1.0 12.273278332183889 -5.253780379809752 24.28112807763916 1.2556595939506288 0.37204423976489603 0.4115404092112156 0.43324947747886633 394.48923043203666 1250626.7506648605 0.11266747541768012 0.28573259151659985 5.57467585775837e-06 5.253780379809752 -0.8836153541857328 GHPHSAS(ph)SPSER ddPTM_A459_Selumetinib_30min_R2 3 GHPHSASSPSER 12 0 C9J470;E9PHA2;Q15003;C9JZP1 C9J470 NCAPH Condensin complex subunit 2 1 GHPHS(0.017)AS(0.483)S(0.483)PS(0.017)ER;GHPHSAS(0.479)S(0.207)PS(0.314)ER;GHPHSAS(0.469)S(0.215)PS(0.316)ER 145.61 0.00044879 11931800.0 15364.2 16093.9 20628.0 19965.6 18977.0 26669.0 43989.0 144592.0 40034.0 79928.0 True False 14510.319271765728 17328.250379955207 19300.81693806824 17246.250837418927 16592.93960346748 30342.412672921924 46034.57566254989 145012.73878150596 48041.9186434206 77620.27096211624 0.18693981729138398 0.2232438790172805 0.24865691267025208 0.22218745984326987 0.2137706993005206 0.39090835804645674 0.5930741427715162 1.86823283382097 0.6189352091655052 1.0 16.244145848939482 -7.533569903165922 24.41200210811088 1.1922815559062572 0.2645400663737167 0.6625472950449154 0.2917067063951654 89.3762029201832 204076.26649199447 0.12774413384180686 0.0738541809917369 2.9270497014210324e-08 7.533569903165922 -0.9277414895325404 GHPHSASS(ph)PSER ddPTM_A459_Selumetinib_30min_R2 1 GHPHSASSPSER 12 0 C9J470;E9PHA2;Q15003;C9JZP1 C9J470 NCAPH Condensin complex subunit 2 1 GHPHSAS(0.139)S(0.53)PS(0.33)ER 164.93 0.00034053 3792100.0 5885.6 5988.2 10652.0 8016.0 8317.1 10744.0 20161.0 65163.0 17942.0 36196.0 True False 5558.501913923556 6447.475684902217 9966.66191702069 6924.206971628705 7272.23154218261 12223.888475678632 21098.52644826362 65352.61354168461 21530.901341366145 35150.92743149777 0.15813243974162505 0.18342263365503164 0.2835390883055291 0.196985043570262 0.20688590809886187 0.3477543657845325 0.6002267362470163 1.8592002634651383 0.6125272621419628 1.0 15.101275133802348 -7.545428469581403 9.533575273126205 1.1888086029286453 0.24752552242745632 0.6705891044612071 0.2906706847142104 0.1582372599504915 62.037143822009284 0.1269223489349083 0.07384684722417606 2.8482068751021443e-08 7.545428469581403 -0.941283080501189 GHQFSCVCLHGDR ddPTM_A459_Selumetinib_30min_R1 1 GHQFSCVCLHGDR 13 0 F1T0B3;A0A087X2G1;Q92499-3;Q92499-2;Q92499 F1T0B3 DDX1 ATP-dependent RNA helicase DDX1 0 134.04 0.00071157 6387400.0 643.48 678.18 957.69 807.44 661.26 588.54 668.43 722.9 405.73 573.12 False True 658.4718320058814 598.7783703226714 827.6409582146156 666.4357615259769 601.4491497549355 582.6198219515646 618.0097869439195 703.7263436898663 688.4941766532542 646.6855346615471 1.0182257012297373 0.9259189176638246 1.2798198101767877 1.030540696839255 0.9300488684499697 0.9009322007743498 0.9556573540296746 1.0882048630609504 1.0646506528301862 1.0 9.336920529702105 GHQFSCVCLHGDR ddPTM_A459_Selumetinib_30min_R2 1 GHQFSCVCLHGDR 13 0 F1T0B3;A0A087X2G1;Q92499-3;Q92499-2;Q92499 F1T0B3 DDX1 ATP-dependent RNA helicase DDX1 0 110.92 0.0030613000000000003 2035200.0 2973.3 2190.5 3042.0 2973.0 2754.6 2055.9 2013.7 3115.0 2167.4 2133.9 False True 2808.055889062954 2358.504306432368 2846.281031879174 2568.0722712889396 2408.5425215635505 2339.0815633979605 2107.341040070851 3124.064134283989 2600.9405622158606 2072.2887624619584 1.3550504832767014 1.1381156666749352 1.3734963405860885 1.2392444131376612 1.1622620192670976 1.1287430621488495 1.0169147650867194 1.5075428631734127 1.2551052774738998 1.0 11.01700933360609 -6.002206758268768 24.581275717004516 1.19392776875386 1.2792369816145812 0.09912911321217055 0.14520268694787652 222.84083500383153 2482337.5413492084 0.04215160103169118 0.061416858918486195 9.949316390128494e-07 6.002206758268768 0.08530921286072113 GHQQLYWSHPR ddPTM_A459_Selumetinib_30min_R2 2 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 ; 166.69 0.0003272 16904800.0 40106.0 32214.0 43601.0 43402.0 47968.0 37504.0 35680.0 41007.0 35373.0 41429.0 False True 37877.069077038585 34684.71021566411 40795.7591291794 37490.572727373874 41941.8310006391 42669.83557258482 37339.190698578706 41126.323580925695 42448.58840419936 40232.83712453092 0.9414466337484322 0.8620995359662573 1.0139916059835923 0.9318401436948373 1.0424775879170143 1.060572373767994 0.9280774950820486 1.022207890873547 1.0550732048254545 1.0 15.296085856542813 -5.544147086386478 1.348430270717661 1.0133028977697822 0.9013425052736732 0.3861825487388061 0.04920044971983323 0.5174107768617965 1.7379662522055062 0.01582053674441975 0.05384046514190793 2.8566229015625716e-06 5.544147086386478 -0.111960392496109 GHSGTTAS(ph)GGENER ddPTM_A459_Selumetinib_30min_R2 2 GHSGTTASGGENER 14 0 Q9BRS8 Q9BRS8 LARP6 La-related protein 6 1 GHSGTT(0.009)AS(0.991)GGENER;GHSGT(0.024)T(0.462)AS(0.514)GGENER 124.99 0.00093675 2101280.0 2304.6000000000004 625.42 602.28 1713.62 1448.17 1342.52 5838.5 11012.0 6870.5 4418.3 True False 2176.5195580447576 673.3877029577411 563.5299605128823 1480.2219998406165 1266.2379377959373 1527.4399438168336 6110.001818768274 11044.043096865256 8244.791977809391 4290.732198877958 0.5072606392479879 0.15694004466972664 0.13133654919322335 0.3449812132828285 0.295109990347816 0.35598584880600675 1.4239998059925674 2.573929712917836 1.921534972507824 1.0 12.06700814440431 -7.3591249852814125 3.305514793094489 1.9455053933711701 0.2780300621239052 0.7774800418035199 0.37704929114836006 0.10261896940574315 2.129811914305239 0.16429401474598845 0.1055998332818356 4.373962091182094e-08 7.3591249852814125 -1.667475331247265 GHTAS(ph)ESDEQQWPEEK ddPTM_A459_Selumetinib_30min_R1 5 GHTASESDEQQWPEEK 16 0 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 GHT(0.001)AS(0.5)ES(0.5)DEQQWPEEK;GHT(0.019)AS(0.977)ES(0.004)DEQQWPEEK;GHTAS(0.986)ES(0.014)DEQQWPEEK;GHT(0.042)AS(0.759)ES(0.199)DEQQWPEEK;GHTAS(0.996)ES(0.004)DEQQWPEEK 337.03 7.911699999999995e-136 55041100.0 10515.98 17454.6 12963.5 15078.900000000001 13344.0 13756.7 15462.4 13015.2 6405.66 10725.140000000001 True False 10760.981873464922 15411.007317576597 11203.127903408371 12445.653181009182 12137.03755607454 13618.320088084214 14296.058719150344 12669.994616672215 10869.937169104287 12101.816190710406 0.8892038768300964 1.2734458262063502 0.9257393871184487 1.0284120155917351 1.002910419792293 1.1253120914642472 1.1813151426084525 1.0469498476103078 0.8982070953489003 1.0 13.562935957025044 -8.140430539919674 6.31811813525149 0.9508071344116661 1.0662141412095272 0.13687577313009802 0.1102092407350185 0.4276403780877804 19.882989216737915 0.07346981760814073 0.02717262488202174 7.237181428725208e-09 8.140430539919674 0.11540700679786109 GHTAS(ph)ESDEQQWPEEK ddPTM_A459_Selumetinib_30min_R2 5 GHTASESDEQQWPEEK 16 0 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 GHTAS(0.985)ES(0.015)DEQQWPEEK;GHT(0.083)AS(0.459)ES(0.459)DEQQWPEEK;GHT(0.139)AS(0.816)ES(0.046)DEQQWPEEK;GHT(0.197)AS(0.789)ES(0.014)DEQQWPEEK;GHT(0.342)AS(0.634)ES(0.024)DEQQWPEEK 199.33 8.408799999999998e-07 92750600.0 352101.0 302556.0 407442.0 381287.0 394253.0 326526.0 351210.0 379004.0 335304.0 378971.0 True False 332532.6359919799 325761.07232912694 381227.6253093083 329355.0528432372 344723.41347346094 371501.9925920923 367541.9609094125 380106.8388925099 402374.16917653807 368029.1225450914 0.9035497889198636 0.8851502567958173 1.0358626585661026 0.8949157353787517 0.9366742802567887 1.009436400095146 0.9986762959618251 1.0328172843059147 1.093321545843804 1.0 18.489460407265277 -7.052618746146687 1.1947961575123247 1.0453306565257783 0.9294783318801889 0.5207554779119294 0.046084782138172006 0.390868281698415 1.1318331957818568 0.027563530103860836 0.018933008260158767 8.858929669340387e-08 7.052618746146687 -0.11585232464558937 GHTAS(ph)ESDEQQWPEEKR ddPTM_A459_Selumetinib_30min_R1 1 GHTASESDEQQWPEEKR 17 1 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 GHT(0.046)AS(0.912)ES(0.042)DEQQWPEEKR 71.434 0.015251 7118100.0 1035.8 1065.9 1606.1 1881.0 1592.8 1168.6 1177.3 1373.7 503.18 829.81 True False 1059.9321246840482 941.1039324765343 1388.000441675797 1552.5186607430435 1448.73152123168 1156.8449450039054 1088.4953131503325 1337.265013593538 853.8597091868595 936.3241965338822 1.132014027414588 1.005104787380638 1.4823930074796163 1.6580994771791775 1.5472541739224996 1.235517515499818 1.1625196883512814 1.428207258280703 0.9119274203824993 1.0 9.870864330427771 -8.266007905914051 24.91206036819968 0.955963654466311 1.3348072838231528 0.37643363761810955 0.1932369940685964 462.04179692541106 2519452.0525011485 0.1859926738006095 0.05433220385879226 5.419910238856264e-09 8.266007905914051 0.3788436293568418 GHTDT(ph)EGRPPSPPPTS(ph)TPEK ddPTM_A459_Selumetinib_30min_R2 1 GHTDTEGRPPSPPPTSTPEK 20 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 2 GHT(0.047)DT(0.71)EGRPPS(0.243)PPPT(0.259)S(0.572)T(0.169)PEK 83.465 0.0097706 16331000.0 101430.0 100840.0 106330.0 108570.0 98895.0 79780.0 87731.0 107160.0 74617.0 98308.0 True False 95792.92665646102 108574.1037482948 99488.84356335054 93782.57870630361 86470.92596748249 90768.97082926669 91810.66533567864 107471.81785870694 89542.48497317584 95469.59260514118 1.003386775228602 1.1372637170177673 1.0420998021310601 0.982329306611635 0.9057431126277363 0.9507631524592747 0.961674422508581 1.1257177801439515 0.9379162781548713 1.0 16.542753682507495 -5.648608021758353 4.054014338884976 0.9806950314247189 1.07419586208082 0.26184968386377716 0.06263857462069015 0.28930256340143773 8.623171081833863 0.01789375100472987 0.03227465061207179 2.2459080833890238e-06 5.648608021758353 0.09350083065610115 GHTDTEGRPPS(ph)PPPT(ph)STPEK ddPTM_A459_Selumetinib_30min_R1 2 GHTDTEGRPPSPPPTSTPEK 20 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 2 GHTDT(0.004)EGRPPS(0.995)PPPT(0.509)S(0.305)T(0.186)PEK;GHT(0.005)DT(0.075)EGRPPS(0.92)PPPT(0.39)S(0.171)T(0.439)PEK 84.156 0.0088476 27023000.0 8445.3 9667.8 10729.2 11335.1 8980.0 8836.3 9244.7 8408.7 5055.9 7716.8 True False 8642.059058306817 8535.889481561717 9272.233571276978 9355.637571179404 8167.760585547772 8747.414844718467 8547.364836049328 8185.673960693007 8579.493031674232 8707.326447997326 0.9925043134559954 0.9803111819156569 1.0648772188172158 1.0744558191373643 0.938033118928985 1.0046039845824732 0.981629078351049 0.9400903950920206 0.9853188671532471 1.0 13.088014097365402 -6.269001411603655 24.998919519281543 0.9737674908098091 1.0272595718799935 0.374102099855917 0.03361550229814098 662.7202441232349 2190843.5499112806 0.010992002704934754 0.01271721519602771 5.38268032960654e-07 6.269001411603655 0.05349208107018444 GHTDTEGRPPS(ph)PPPTS(ph)TPEK ddPTM_A459_Selumetinib_30min_R2 1 GHTDTEGRPPSPPPTSTPEK 20 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 2 GHT(0.023)DT(0.1)EGRPPS(0.877)PPPT(0.085)S(0.503)T(0.413)PEK 77.23100000000002 0.010591 16133000.0 52913.0 46745.0 49032.0 56074.0 52826.0 45205.0 48241.0 44018.0 37674.0 62525.0 True False 49972.307287521624 50330.19119113493 45877.33450200514 48436.62446695461 46189.52560956807 51431.57841986709 50484.30208772803 44146.085092427835 45209.85269951108 60719.740790540294 0.8229993513955671 0.8288933802394627 0.75555880023046 0.7977080243811036 0.7607003094579098 0.8470322460249989 0.83143144931859 0.7270466658399418 0.7445659699942997 1.0 15.889878011524827 -11.101770108503516 3.257905609331837 1.0088641592115728 0.7910641018848782 0.7152693530080995 0.03962310808943263 355927645.24633783 347894906.6131093 26683448.785733413 0.010452683341902089 7.910972803628388e-12 11.101770108503516 -0.2178000573266946 GHTDTEGRPPS(ph)PPPTSTPEK ddPTM_A459_Selumetinib_30min_R1 2 GHTDTEGRPPSPPPTSTPEK 20 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 1 GHTDTEGRPPS(0.998)PPPTSTPEK;GHT(0.134)DT(0.134)EGRPPS(0.728)PPPT(0.002)S(0.001)TPEK 73.404 0.004096100000000001 119515000.0 7830.7 9014.4 9833.8 9707.3 9031.3 8092.0 8596.1 7554.0 4411.6 6933.2 True False 8013.140074110231 7958.989857319136 8498.423973196843 8012.1022835890135 8214.420509605523 8010.601826948147 7947.689256240183 7353.643381149879 7486.162989484373 7823.1437550869605 1.0242864409719847 1.017364643484129 1.0863182678537364 1.0241537845165103 1.050015283723265 1.0239619873710353 1.015920134545941 0.9399857156361481 0.9569251472103567 1.0 12.933532760283354 -7.595470059572875 3.9847601562905557 0.9616799074657643 1.0379106354258834 0.6494866955575771 0.02351958008632222 0.12900322338853093 4.0370122101075445 0.011758895149960357 0.006515103055539755 2.538223966059842e-08 7.595470059572875 0.0762307279601191 GHTDTEGRPPS(ph)PPPTSTPEK ddPTM_A459_Selumetinib_30min_R2 2 GHTDTEGRPPSPPPTSTPEK 20 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 1 GHTDTEGRPPS(0.999)PPPTSTPEK;GHT(0.002)DT(0.001)EGRPPS(0.997)PPPTSTPEK 75.10600000000002 0.0026587 167042000.0 188839.0 150488.0 174574.0 189040.0 202414.0 144701.0 143666.0 175326.0 143288.0 169056.0 True False 178344.08436241167 162029.94570481344 163342.09890180005 163292.42588781097 176984.94371588077 164632.24928510532 150346.75366877846 175836.1696332184 171949.60380123038 164174.91401976143 1.0863053312818833 0.9869348595200738 0.9949272693521184 0.9946247078171502 1.078026717861277 1.0027856586255854 0.9157717825920804 1.0710294607619124 1.0473561373726872 1.0 17.324874174121497 -9.626055681677675 0.0017697536483677343 0.11715759317236388 1.90459132229635 0.009980291951181108 0.04974201937576923 1257827.1749850758 631.1570673521965 320920.28821754054 316541.13808129134 2.3656163781053757e-10 9.626055681677675 1.7874337291239861 GHVECLR ddPTM_A459_Selumetinib_30min_R2 1 GHVECLR 7 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;D6RB27;D6R9G4;D6RBY4;D6REL2;D6R9G6;D6RF74;D6RE17;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 0 98.418 0.030727 775850.0 3496.7 2269.7 3064.1 3102.6 3050.6 2291.3 2279.1 2519.3 1928.3 2220.7 False True 3302.3674123991627 2443.77869176423 2866.959141939832 2680.0205277164687 2667.3563552899786 2606.9057766495184 2385.0826659509735 2526.6307459074333 2314.0138812036757 2156.5826209284755 1.5312964967590212 1.1331718377254232 1.3293991679787893 1.2427163706636182 1.2368440371376077 1.2088133101653045 1.1059546909100666 1.1715900524226799 1.0730003380104312 1.0 11.074531272944322 -1.5228787477214039 0.12820278385424078 0.9334932282271542 2.425649130288358 0.638043460763649 0.08506189921418791 56.2332296461405 0.49112512294579447 0.45475937962306845 15.125578831242837 0.029999999831377116 1.5228787477214039 1.4921559020612036 GHVS(ph)PAEDQTIQAPPVSVSALAR ddPTM_A459_Selumetinib_30min_R1 1 GHVSPAEDQTIQAPPVSVSALAR 23 0 E9PEM3;H0Y6E6;Q92622-3;Q92622-2;Q92622;H7C357 E9PEM3 KIAA0226 Run domain Beclin-1 interacting and cysteine-rich containing protein 1 GHVS(1)PAEDQTIQAPPVSVSALAR 91.767 9.2792e-05 8125400.0 1063.6 1469.1 1531.1 1264.5 1395.1 977.46 1096.5 1004.1 655.63 901.54 True False 1088.3798105946644 1297.0970890339395 1323.1850297302854 1043.6788126047732 1268.9134513249098 967.6276398626707 1013.7901222027851 977.4680062235361 1112.556224679399 1017.2614407432499 1.0699115949971059 1.275087246093031 1.3007325125422193 1.0259691076486903 1.247381843548295 0.9512084122206432 0.996587584664638 0.9608818019381142 1.0936777706491294 1.0 9.990474790594217 -6.764055921142718 24.999356489121674 0.9977834913025977 1.1866131060485205 0.5225964403793886 0.08757999829714481 55.53166030631196 530564.2936040643 0.029950177867733355 0.02761627615228467 1.7216468759698542e-07 6.764055921142718 0.18882961474592286 GHVT(ph)PNLSR ddPTM_A459_Selumetinib_30min_R2 1 GHVTPNLSR 9 0 Q96CP6-2;Q96CP6-3;Q96CP6;M0QZ12 Q96CP6-2 GRAMD1A GRAM domain-containing protein 1A 1 GHVT(1)PNLSR 86.911 0.045036 8258100.0 22475.0 8440.3 19381.0 17278.0 14037.0 12456.0 20936.0 21235.0 15172.0 13953.0 True False 21225.929474553493 9087.643870158008 18134.047560437288 14924.706593787518 12273.54656762781 14171.700935689969 21909.565483896986 21296.7903343565 18206.82394109951 13550.140635752254 1.5664730016564221 0.6706678634891893 1.338292202856576 1.1014429292643981 0.9057873934713172 1.0458711327539818 1.6169253200286542 1.5717025311283186 1.3436630977143162 1.0 13.726020204814901 -7.245241946800929 24.20489618976017 1.4307146182833597 1.0864451532970265 0.1892558244286786 0.27365634659975907 699.2843052350354 1044987.9051668455 0.09909439407915566 0.07649813080729535 5.685361093735694e-08 7.245241946800929 -0.34426946498633315 GHYAYDCHR ddPTM_A459_Selumetinib_30min_R1 3 GHYAYDCHR 9 0 Q16629;C9JAB2;Q16629-4;A0A0B4J1Z1;Q16629-3;Q16629-2;F8WEA1 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 0 ;; 127.68 0.006331 3015700.0 1290.87 1760.9 1316.75 1334.44 1760.1100000000001 1408.61 1282.67 1284.4299999999998 1075.31 1492.0800000000002 False True 1320.9447594042265 1554.7330093798003 1137.942582390017 1101.4051045411732 1600.9083612726592 1394.4406623155496 1185.9171692164591 1250.3627439833645 1824.7225324649662 1683.6030020899664 0.7845939676779213 0.9234558310063647 0.6758972162543155 0.6541952605061448 0.9508823394145456 0.828247906771691 0.7043924058963441 0.742670773591641 1.083819956486071 1.0 10.717336271974746 -8.261406352856643 24.999999998634436 1.0419100035347495 0.7843359320690853 0.5454080338479863 0.09452819027131565 2.2884439909195105 1735980.5115621216 0.07731706192485904 0.02486891955470107 5.4776420290612615e-09 8.261406352856643 -0.25757407146566424 GHYAYDCHR ddPTM_A459_Selumetinib_30min_R2 4 GHYAYDCHR 9 0 Q16629;C9JAB2;Q16629-4;A0A0B4J1Z1;Q16629-3;Q16629-2;F8WEA1 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 0 ;;; 116.37 0.011058 8311500.0 3967.92 2267.77 2918.33 4120.29 3390.82 2927.2099999999996 2786.49 2916.3399999999997 865.47 2493.2200000000003 False True 3747.398891242279 2441.7006669701577 2730.567825037459 3559.0993941032984 2964.834877284586 3330.4066069332844 2916.067306325185 2924.8260665739235 1038.5881832522664 2421.234260436482 1.5477225613711272 1.0084528816017935 1.1277586269348479 1.469952516474672 1.2245138464008467 1.3754995381293271 1.2043722303018702 1.2079897077148816 0.4289498956061515 1.0 11.24152695508523 -8.149520801593912 6.591835100997812 0.7195763600248166 1.2673093010625147 0.5618088773099359 0.19696080053646695 0.15939477219723497 8.044527971537839 0.12834572867554847 0.047604321623089016 7.0872735941199e-09 8.149520801593912 0.5477329410376981 GHYEVT(ph)GSDDETGKLQGSGVSLASK ddPTM_A459_Selumetinib_30min_R1 3 GHYEVTGSDDETGKLQGSGVSLASK 25 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GHY(0.078)EVT(0.338)GS(0.292)DDET(0.292)GKLQGS(0.001)GVSLASK;GHY(0.021)EVT(0.489)GS(0.489)DDET(0.001)GKLQGSGVSLASK;GHY(0.021)EVT(0.528)GS(0.447)DDET(0.004)GKLQGSGVSLASK 101.93 3.3836e-06 460500000.0 5531.670000000001 5891.4 5811.799999999999 5966.099999999999 6155.3 5273.4 5491.0 5353.76 3208.0 4965.12 True False 5660.547148243879 5201.632149162444 5022.5894819322575 4924.2326325672875 5598.554201806482 5220.3543838641035 5076.809449170534 5211.760893336639 5443.741696950281 5602.441516364358 1.010371483880697 0.9284580899182657 0.8965001182540877 0.8789440493370493 0.99930613919904 0.9317998891404393 0.9061780358333974 0.9302660060106711 0.971673096640005 1.0 12.451839968247555 -8.458817186636171 3.1058307871846 0.9994359137374326 0.9329296436772879 0.22320184197690263 0.03926320650274684 0.3440182934795657 6.934438126076397 0.03848263764920704 0.01027518455785561 3.476824852658891e-09 8.458817186636171 -0.06650627006014465 GHYEVT(ph)GSDDETGKLQGSGVSLASK ddPTM_A459_Selumetinib_30min_R2 1 GHYEVTGSDDETGKLQGSGVSLASK 25 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GHY(0.093)EVT(0.483)GS(0.421)DDET(0.003)GKLQGSGVS(0.001)LASK 74.579 0.0004498 110830000.0 81083.0 80520.0 80286.0 88446.0 69508.0 67604.0 84558.0 86302.0 58877.0 78775.0 True False 76576.73146096633 86695.62508739295 75120.48616878738 76399.50222213981 60775.78363059584 76915.8373519897 88490.11454849828 86553.12453193478 70654.04516083017 76500.56106796996 1.0009956841091492 1.1332678332955595 0.9819599375492633 0.9986789790242144 0.7944488613174638 1.0054284083439697 1.1567250398317437 1.131405094598368 0.9235755159763439 1.0 16.2231827083614 -9.461919214769495 14.492167213898972 0.9999999999744887 1.0170991240029486 0.0008859690728159064 0.1031241075509512 0.0 0.0 0.10683246322707086 0.025910678242948695 3.4520794717441695e-10 9.461919214769495 0.01709912402845981 GHYEVTGS(ph)DDETGK ddPTM_A459_Selumetinib_30min_R1 4 GHYEVTGSDDETGK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GHYEVTGS(1)DDETGK;GHYEVTGS(1)DDETGK;GHYEVT(0.005)GS(0.994)DDET(0.001)GK;GHYEVT(0.226)GS(0.774)DDETGK 255.39 2.9991e-28 269923000.0 39494.3 45662.5 23859.8 22518.7 24023.899999999998 26185.4 30141.800000000003 29690.299999999996 16845.300000000003 30491.5 True False 40414.44034746981 40316.313272079664 20619.77021249996 18586.23177335161 21850.94248676404 25921.998650440924 27868.179758697614 28902.816796313757 28585.243767966535 34405.38103736141 1.1746546362495756 1.1718025511270886 0.5993181761338027 0.5402129321912899 0.6351024702512585 0.7534286169448834 0.8099948007677946 0.840066754817442 0.8308364245966442 1.0 15.070346601127943 -5.249922770142773 24.645418926600648 0.7359173628152971 1.1732287001972082 0.6354058651209613 0.1274824566353071 385.63987724551436 825260.2779529296 0.03465833757813591 0.08996745453131559 5.624413342943025e-06 5.249922770142773 0.4373113373819111 GHYEVTGS(ph)DDETGK ddPTM_A459_Selumetinib_30min_R2 6 GHYEVTGSDDETGK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GHYEVTGS(1)DDETGK;GHYEVT(0.002)GS(0.996)DDET(0.002)GK;GHYEVTGS(1)DDETGK;GHYEVT(0.016)GS(0.984)DDETGK;GHYEVT(0.142)GS(0.858)DDETGK;GHYEVT(0.022)GS(0.971)DDET(0.007)GK 207.64 7.6967e-11 544749100.0 676405.5 444383.89999999997 506706.5 515882.4 491391.1 506484.2 729677.0 669079.0 556968.3 414073.30000000005 True False 638813.5901757552 478466.71621055 474105.5554503244 445618.3271732223 429658.1569258286 576247.8011442017 763608.4263275453 671025.9091180085 668377.5229945631 402117.92793736386 1.5886225054737186 1.1898666609191288 1.1790211838656786 1.1081782139358738 1.0684879411612669 1.4330318573459904 1.8989663809430781 1.6687291525647452 1.6621430594327378 1.0 18.61725913280774 -6.992442126433023 8.714422540638818 1.6208517411655525 1.2185737491929183 0.2638047735693757 0.2531517523180297 0.14545225390875002 101.88672808040744 0.08770153878091966 0.07526292836963773 1.0175549553112811e-07 6.992442126433023 -0.40227799197263425 GHYEVTGS(ph)DDETGKLQGSGVSLASK ddPTM_A459_Selumetinib_30min_R2 9 GHYEVTGSDDETGKLQGSGVSLASK 25 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GHY(0.013)EVT(0.218)GS(0.708)DDET(0.059)GKLQGS(0.001)GVSLASK;GHY(0.004)EVT(0.056)GS(0.939)DDET(0.001)GKLQGSGVSLASK;GHY(0.002)EVT(0.104)GS(0.886)DDET(0.007)GKLQGSGVSLASK;GHY(0.024)EVT(0.121)GS(0.641)DDET(0.215)GKLQGSGVSLASK;GHY(0.018)EVT(0.206)GS(0.734)DDET(0.041)GKLQGS(0.001)GVSLASK;GHY(0.004)EVT(0.027)GS(0.96)DDET(0.004)GKLQGS(0.002)GVS(0.003)LASK;GHY(0.038)EVT(0.217)GS(0.724)DDET(0.02)GKLQGSGVSLASK;GHY(0.001)EVT(0.11)GS(0.886)DDET(0.003)GKLQGSGVSLASK;GHY(0.009)EVT(0.158)GS(0.695)DDET(0.137)GKLQGS(0.001)GVSLASK 110.26 1.0773e-07 369433400.0 427556.0 387035.3 395126.7 448287.4 395742.0 328048.0 433580.0 403708.4 331987.9 366134.3 True False 403794.1491622779 416719.66299536376 369704.67830342223 387229.8827811015 346025.3519816318 373233.63427675166 453742.32912247046 404883.12460647675 398394.7565169617 355563.0514278439 1.135647102646777 1.1719993439192615 1.0397724870983907 1.0890610855826899 0.9731757858193888 1.0496974665335657 1.2761233972437953 1.138709781515759 1.1204616309740771 1.0 18.439745887773896 GHYEVTGSDDET(ph)GKLQGSGVSLASK ddPTM_A459_Selumetinib_30min_R1 2 GHYEVTGSDDETGKLQGSGVSLASK 25 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GHY(0.039)EVT(0.182)GS(0.155)DDET(0.624)GKLQGS(0.001)GVSLASK;GHY(0.004)EVT(0.011)GS(0.166)DDET(0.818)GKLQGS(0.001)GVSLASK 84.32700000000001 0.00015082 24585000.0 2205.6 2634.2 2480.4 2157.0699999999997 2268.7 2237.9 2194.8999999999996 2077.1 1467.25 1821.58 True False 2256.986188649485 2325.786639393643 2143.575303861931 1780.3782177187647 2063.496485571516 2215.388757850625 2029.3369258758723 2022.0085606283317 2489.8160862999707 2055.39753669176 1.0980776946352626 1.131550757396102 1.042900590078597 0.8661965317835064 1.0039403320940006 1.0778395508911514 0.9873208903140787 0.9837554655645014 1.2113550015766896 1.0 11.005201738786672 -10.783777080055271 14.743657036891376 0.9999998979136218 1.0383033694448116 0.017493663029666595 0.08954073133381385 0.0 0.0 0.0896140305517109 0.021734594911884245 1.6452159829558396e-11 10.783777080055271 0.03830347153118985 GHYTEGAELVDS(ph)VLDVVR ddPTM_A459_Selumetinib_30min_R1 1 GHYTEGAELVDSVLDVVR 18 0 P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;G3V2A3;Q9BVA1;Q13885 P68371;P07437;A0A0B4J269;Q9BVA1 TUBB4B;TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 1 GHYTEGAELVDS(1)VLDVVR 96.881 0.0024148000000000004 2096600.0 440.98 864.31 441.56 819.7 865.88 627.0 655.99 628.18 218.81 396.35 True False 451.2539760022901 763.116183393182 381.59857731546265 676.55478267468 787.5613068835303 620.6929492704508 606.5081461594214 611.5186257837872 371.30458874990387 447.2253832759356 1.0090079697553054 1.7063346847697676 0.8532578685946778 1.5127826102331259 1.760994201882341 1.3878750457406095 1.3561576977512682 1.3673611754869548 0.8302404171026468 1.0 8.804858263660345 -8.253365557870884 23.149706026198356 0.9151201992266345 1.381290577182484 0.31963311188849985 0.2645391807225775 222.51784850201997 638028.4673466976 0.1820133595079901 0.0657807899708827 5.580003124629055e-09 8.253365557870884 0.4661703779558495 GHYTEGAELVDSVLDVVR ddPTM_A459_Selumetinib_30min_R1 2 GHYTEGAELVDSVLDVVR 18 0 P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;G3V2A3;Q9BVA1;Q13885 P68371;P07437;A0A0B4J269;Q9BVA1 TUBB4B;TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 0 ; 223.15 1.538e-14 85006000.0 8926.7 9404.599999999999 8651.6 9364.2 11240.099999999999 8851.2 9901.8 9058.8 3891.2 6291.7 False True 9134.674741665476 8303.505059920077 7476.760239837073 7728.918257804357 10223.434939600833 8762.164964246585 9154.899254015081 8818.531196870603 6603.082197996555 7099.300981347808 1.2867005872360198 1.1696229081899905 1.0531685104605333 1.0886872211941372 1.4400621929484534 1.234229255424959 1.2895493905763404 1.2421689431170444 0.9301031489360737 1.0 12.793461264154066 -10.0814803410806 6.559686310241112 1.000523240419827 1.197658394746904 0.15314666092594886 0.13548977838771437 0.0 0.0 0.13446430912590343 0.03261238525892969 8.28933438202364e-11 10.0814803410806 0.19713515432707696 GHYTIGK ddPTM_A459_Selumetinib_30min_R1 1 GHYTIGK 7 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;P68363;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA1A;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 97.473 0.031583 15289000.0 13510.0 15180.0 10628.0 9835.7 14746.0 14033.0 13357.0 13388.0 6230.1 9416.5 False True 13824.75671411614 13402.718543009454 9184.775975425171 8118.079633955529 13412.226903617746 13891.840760944557 12349.47073621761 13032.90674964716 10572.02467149936 10625.199499477345 1.3011291425442113 1.261408648719371 0.8644332726060316 0.764040207843143 1.262303536444421 1.3074428166386804 1.1622813046310407 1.2266034863899027 0.9949954042763525 1.0 13.375202309195513 GHYTIGK ddPTM_A459_Selumetinib_30min_R2 2 GHYTIGK 7 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;P68363;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA1A;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 107.66 0.023326 54162000.0 500840.0 392210.0 478060.0 676320.0 804320.0 594870.0 734890.0 983460.0 845320.0 851180.0 False True 473005.3178213728 422291.2458460808 447302.1400723725 584204.0492829245 703274.1308879673 676807.9428077947 769063.841156909 986321.7057794326 1014407.6202142247 826604.2217687644 0.5722270771969177 0.5108747750434467 0.5411321746158484 0.7067518334625088 0.8507991035699093 0.8187811348937508 0.930389442617737 1.193221229464453 1.2271986925539762 1.0 19.656837206537006 -6.750935439731166 0.7234971171557968 1.1571092675443087 0.5163597673780479 0.8750252985379319 0.08629679475225212 0.23307685184342264 0.2682380900705418 0.06572697495130476 0.06667019967877058 1.774453243541326e-07 6.750935439731166 -0.6407495001662608 GIAPAS(ph)PMLGNASNPNK ddPTM_A459_Selumetinib_30min_R1 2 GIAPASPMLGNASNPNK 17 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 GIAPAS(1)PMLGNASNPNK;GIAPAS(1)PMLGNASNPNK 302.4 2.591099999999999e-89 52898000.0 7007.5 9354.2 5771.4 6833.6 6458.9 6328.1 7166.6 5588.1 3169.7 6149.3 True False 7170.761115778598 8259.005915350403 4987.67558003094 5640.240042559093 5874.693635411412 6264.445059455083 6626.017592137241 5439.885435293041 5378.749394271607 6938.622554254343 1.0334560007709197 1.1902947380076871 0.7188279144789047 0.8128760425368345 0.8466656875303594 0.9028369839218454 0.9549471152706769 0.7840007714438412 0.775189794835242 1.0 12.760433574067239 -5.254999304128128 24.99983757567456 0.845977125126303 1.1118753827879035 0.5877292675184437 0.08788900175987205 337.59879927966523 1310521.5117291077 0.02240018191352744 0.05637015522899225 5.559051479988432e-06 5.254999304128128 0.2658982576616006 GIAPAS(ph)PMLGNASNPNK ddPTM_A459_Selumetinib_30min_R2 3 GIAPASPMLGNASNPNK 17 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 GIAPAS(1)PMLGNASNPNK;GIAPAS(1)PMLGNASNPNK;GIAPAS(1)PMLGNASNPNK 230.45 2.0678999999999998e-16 58833000.0 291506.0 219087.0 264294.0 252393.0 259520.0 235351.0 259920.0 276759.0 220736.0 215503.0 True False 275305.26351097634 235890.26842426325 247289.61178155013 218016.6379977898 226916.77746176315 267768.4639463364 272006.7950217089 277564.32287008135 264889.367879155 209280.8684459625 1.315482229958644 1.1271468346623927 1.181615948069337 1.041741844902956 1.0842690932370358 1.2794693845389682 1.2997212647363539 1.3262766201763447 1.2657122929875022 1.0 17.675080907102206 -6.77397529459773 24.993237838743575 1.258721054899996 1.144515134928668 0.10925590030931209 0.10897731636824844 368.5193459238892 734724.3651660199 0.03736586288608248 0.03317882769733953 1.682769784879395e-07 6.77397529459773 -0.11420591997132812 GIAPAS(ph)PMLGNASNPNKADIPER ddPTM_A459_Selumetinib_30min_R1 5 GIAPASPMLGNASNPNKADIPER 23 1 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 GIAPAS(1)PMLGNASNPNKADIPER;GIAPAS(0.999)PMLGNAS(0.001)NPNKADIPER;GIAPAS(1)PMLGNASNPNKADIPER;GIAPAS(1)PMLGNASNPNKADIPER;GIAPAS(1)PMLGNASNPNKADIPER 144.83 1.478e-07 121261400.0 9154.46 11159.08 14072.9 15262.099999999999 12553.59 11285.25 10751.400000000001 9344.36 6220.07 8464.48 True False 9367.741106521658 9852.569725884456 12161.877476906362 12596.860740099088 11418.120001016323 11171.730631187167 9940.4132419982 9096.517218040997 10555.004494061577 9550.978459017264 0.9808148083170884 1.0315770021010207 1.2733645593582192 1.3189078788263988 1.1954921739181867 1.1696948830032927 1.0407743337137634 0.9524173106528996 1.1051228457223032 1.0 13.221432823638974 -7.298749015272295 4.596200391860875 1.0179541442445033 1.1699468381066789 0.3080026264919107 0.10040730195370748 0.2813385474859894 14.329625967124956 0.047690034424764605 0.0324337899159163 5.026329840866543e-08 7.298749015272295 0.15199269386217562 GIAPAS(ph)PMLGNASNPNKADIPER ddPTM_A459_Selumetinib_30min_R2 3 GIAPASPMLGNASNPNKADIPER 23 1 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 GIAPAS(0.994)PMLGNAS(0.006)NPNKADIPER;GIAPAS(1)PMLGNASNPNKADIPER;GIAPAS(0.998)PMLGNAS(0.002)NPNKADIPER 109.65 9.1259e-06 62308900.0 158156.0 158615.0 164794.0 162161.0 160990.0 121518.0 110127.0 114350.0 83475.0 141472.0 True False 149366.32266863092 170780.26047238955 154191.33345414055 140074.3920566721 140764.99693113932 138256.0014694261 115248.12371251051 114682.73956833854 100172.33248637515 137387.33577160063 1.087191347221004 1.2430567891374131 1.1223111110508446 1.0195582530950202 1.0245849527583377 1.006322749421894 0.8388555107008159 0.8347402540725638 0.7291234808782266 1.0 17.0678894985232 -6.630390575688565 0.8599114586080219 0.829659474463103 1.1610112864336428 0.6848963838784594 0.08104135131460415 0.3222559615393036 0.5243418701745374 0.04839622500460591 0.052269119791378355 2.3421215189328407e-07 6.630390575688565 0.33135181197053987 GIASTSDPPTANIKPT(ph)PVVSTPSK ddPTM_A459_Selumetinib_30min_R1 1 GIASTSDPPTANIKPTPVVSTPSK 24 1 P12270 P12270 TPR Nucleoprotein TPR 1 GIAS(0.001)T(0.001)S(0.003)DPPT(0.003)ANIKPT(0.628)PVVS(0.168)T(0.168)PS(0.029)K 57.826 0.016438 38749000.0 2353.8 3942.6 2490.4 2383.5 2275.7 2509.9 2960.9 2683.9 1252.3 2690.0 True False 2408.638960302484 3480.9985591349846 2152.217358787998 1967.2664688362809 2069.8633368074666 2484.652684806863 2737.5569291657334 2612.714253464148 2125.0616356268206 3035.2877028188896 0.7935455205994367 1.1468430343199956 0.7090653570629305 0.6481317955491563 0.6819331606968171 0.8185888548552914 0.9019101967247942 0.8607797709053099 0.7001186851754657 1.0 11.567617554934856 -5.283223159712464 24.83171598765689 0.7811759711391494 0.9701943489672398 0.2297476218312503 0.13112090348083955 880.1171745226401 1003259.9007566472 0.034218653706009954 0.07133110962693323 5.209269670067628e-06 5.283223159712464 0.1890183778280904 GIASTSDPPTANIKPTPVVS(ph)TPSK ddPTM_A459_Selumetinib_30min_R1 1 GIASTSDPPTANIKPTPVVSTPSK 24 1 P12270 P12270 TPR Nucleoprotein TPR 1 GIASTSDPPT(0.014)ANIKPT(0.017)PVVS(0.459)T(0.459)PS(0.05)K 76.55 0.00021077 44681000.0 4215.5 6375.9 3955.5 3824.5 3722.8 4191.5 4879.6 4517.4 2437.7 4292.1 True False 4313.712948064886 5629.406663924504 3418.3648260062355 3156.622869756391 3386.073397313723 4149.337315577501 4511.527843411499 4397.583877416795 4136.598857436316 4843.032843594407 0.89070487179751 1.1623721840685404 0.7058314358795862 0.6517863850400002 0.6991638311502022 0.8567642321619983 0.9315501234683201 0.908022724486211 0.8541339675008711 1.0 12.241695071440176 -8.559880150908588 0.7618378983071716 0.9919078389524757 0.8343386623133939 0.10060416440011666 0.1381059411784838 2.0587667020892577 2.673599785669269 0.15078794599022197 0.05659296374887284 2.754988872698128e-09 8.559880150908588 -0.15756917663908176 GIASTSDPPTANIKPTPVVS(ph)TPSK ddPTM_A459_Selumetinib_30min_R2 1 GIASTSDPPTANIKPTPVVSTPSK 24 1 P12270 P12270 TPR Nucleoprotein TPR 1 GIASTSDPPTANIKPT(0.008)PVVS(0.398)T(0.398)PS(0.196)K 76.60600000000002 0.00020971 43786000.0 35445.0 34263.0 33773.0 36589.0 32415.0 30830.0 32729.0 32356.0 25778.0 32652.0 True False 33475.108797577224 36890.86192709069 31600.0819492621 31605.51508045445 28342.737906223243 35076.55265312474 34250.96335128314 32450.15060317585 30934.320297499515 31709.251919915598 1.05568901095874 1.1634100362967152 0.9965571571688536 0.9967284993123413 0.8938318058655319 1.1061930045437067 1.0801567768860285 1.0233653788216592 0.9755613401295862 1.0 14.952616221539968 -5.276210164792884 24.76635644195573 1.0113377590160084 1.1095495259582515 0.31330603660136036 0.05943752561439561 783.7061383910756 1314049.6882381071 0.016311586346053352 0.03419013429838792 5.294071899380163e-06 5.276210164792884 0.0982117669422431 GIASTSDPPTANIKPTPVVST(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 GIASTSDPPTANIKPTPVVSTPSK 24 1 P12270 P12270 TPR Nucleoprotein TPR 1 GIASTSDPPTANIKPT(0.066)PVVS(0.186)T(0.72)PS(0.028)K 87.196 0.00012194 39511000.0 44118.0 40317.0 41614.0 47538.0 41099.0 42470.0 39223.0 44302.0 37913.0 45368.0 True False 41666.09817834705 43409.184260412585 38936.60054589738 41063.24239237595 35935.776190278244 48319.85699572515 41046.947218900044 44430.91148540907 45496.65937772906 44058.10795977985 0.945707841480246 0.985271185499848 0.8837556206780863 0.9320246441327467 0.8156450164197611 1.0967301873207038 0.9316547877265029 1.008461632668601 1.0326512300360797 1.0 15.42711992053348 -6.766285902153347 24.999722471514925 1.0092881017728845 0.9160146910309427 0.44895064895892756 0.05599558844320303 126.56661236165749 652861.7220920444 0.019300857407123125 0.01756013109127817 1.7128293566688573e-07 6.766285902153347 -0.09327341074194184 GIAYIEFK ddPTM_A459_Selumetinib_30min_R2 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 138.9 0.033783 2486400.0 29043.0 24389.0 27175.0 32855.0 25841.0 23522.0 26469.0 27757.0 23148.0 27358.0 False True 27428.906328340676 26259.557877004794 25426.590085902862 28380.092321963722 22594.622558528914 26761.94198854363 27699.86094732849 27837.768274581278 27778.246809159707 26568.10345537947 1.0323998615259424 0.9883866163464444 0.9570344427710561 1.0682016640603438 0.8504416808100763 1.0072959115613844 1.04259835459651 1.047789064858701 1.045548729355584 1.0 14.697407625323859 -6.999732469349051 24.999999847152235 1.0361065671864838 0.978037665709279 0.1836545907844287 0.054300303060175886 15.391922825928546 1438120.6775950948 0.01897008559281412 0.016568409666649662 1.0006162018632067e-07 6.999732469349051 -0.05806890147720478 GICFIR ddPTM_A459_Selumetinib_30min_R1 1 GICFIR 6 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 142.14 0.00069079 0.0 2847.0 2709.4 3076.8 3506.7 3100.9 2869.5 2748.3 2599.8 1761.8 2760.7 False True 2913.329560702344 2392.182188434111 2658.98745965263 2894.3206739115526 2820.4241425083587 2840.635435297539 2540.993518330976 2530.844858659445 2989.6459232191423 3115.0627364952084 0.9352394500985761 0.7679402923119236 0.853590339770905 0.9291372016372245 0.9054148763891828 0.911903122212418 0.8157118277463252 0.8124538966771907 0.9597385915196129 1.0 11.605045503679934 -8.446056917686272 5.160900305039987 0.9993154789349471 0.8662624542142409 0.43519106487321635 0.052611753135315784 0.18666230908394496 8.238873680565275 0.05262771221305624 0.013686942064639678 3.5804950884091894e-09 8.446056917686272 -0.13305302472070624 GIDS(ph)DDVQDNSQLK ddPTM_A459_Selumetinib_30min_R2 1 GIDSDDVQDNSQLK 14 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 GIDS(0.999)DDVQDNS(0.001)QLK 87.13799999999998 0.02244 5035800.0 16528.0 13907.0 17018.0 15126.0 13576.0 12726.0 14219.0 13491.0 9755.7 15271.0 True False 15609.439926826251 14973.622181947003 15923.080407797413 13065.812706194587 11870.4615090201 14478.890984873995 14880.21167441399 13530.256576444717 11707.112597032985 14830.086551176984 1.052552179851399 1.0096786778873268 1.0737011111060362 0.8810341504822589 0.8004310337675006 0.97631871094676 1.0033799616114194 0.9123518281402676 0.7894163366230559 1.0 13.85623939720642 -5.762847315574456 24.997472231025828 0.9075532254651704 1.0417474718946944 0.4342113982451229 0.07126137746562577 36.95851663392066 656209.4630832332 0.0207078806734515 0.03270198029663367 1.7264447495585989e-06 5.762847315574456 0.13419424642952404 GIEFEDES(ph)SDRDARPALETQPQQEK ddPTM_A459_Selumetinib_30min_R1 2 GIEFEDESSDRDARPALETQPQQEK 25 2 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 GIEFEDES(0.5)S(0.5)DRDARPALETQPQQEK;GIEFEDES(0.773)S(0.227)DRDARPALETQPQQEK 62.108 0.0054727 10761000.0 3470.49 3359.7000000000003 3750.1 4157.1 3768.6000000000004 3258.9700000000003 3744.2999999999997 3635.4 1823.91 3319.3900000000003 True False 3551.345664601993 2966.3447621178434 3240.857017824798 3431.1405234316358 3427.7307954003713 3226.1877207080074 3461.864436446774 3538.9773825565617 3095.042056884225 3745.4660400966504 0.9481719034650097 0.7919828214598624 0.8652747036363915 0.9160783963063502 0.9151680348200193 0.8613581557462892 0.9242813576164322 0.9448697023736036 0.8263436442222711 1.0 11.870929525884113 -14.52287874527936 0.22099618614050254 1.5561268500769618 0.8748659632834099 0.29365575944937417 0.04986299611209696 192.51140937004212 1.9213964495137152 47.85525670134175 0.09295800403564214 3.00000000000675e-15 14.52287874527936 -0.6812608867935519 GIEFEDES(ph)SDRDARPALETQPQQEK ddPTM_A459_Selumetinib_30min_R2 1 GIEFEDESSDRDARPALETQPQQEK 25 2 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 GIEFEDES(0.497)S(0.497)DRDARPALET(0.006)QPQQEK 54.12 0.016503999999999998 6628900.0 21668.0 17578.0 20045.0 22113.0 22614.0 19536.0 14790.0 14532.0 10671.0 18911.0 True False 20463.779303876534 18926.17607782158 18755.326523345822 19101.1712529473 19773.02714827494 22226.906669849002 15477.764305829014 14574.285714097896 12805.498172651767 18364.99029332121 1.1142820647892522 1.0305573689687413 1.021254366258313 1.0400861066555431 1.076669621517077 1.2102868727315501 0.842786413639315 0.7935907115288877 0.6972776989328842 1.0 14.164670513093506 -7.375353606341019 6.514616284817676 0.8115553350205263 1.0744166994492328 0.6616039241381516 0.08669614784531832 0.14326259841370026 7.261324262372189 0.03608628276445543 0.024138497611780885 4.213532942120329e-08 7.375353606341019 0.26286136442870645 GIEFEDESS(ph)DRDARPALETQPQQEK ddPTM_A459_Selumetinib_30min_R2 1 GIEFEDESSDRDARPALETQPQQEK 25 2 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 GIEFEDES(0.465)S(0.535)DRDARPALETQPQQEK 75.797 0.00033665 6354600.0 23964.0 19960.0 24140.0 29800.0 26721.0 18762.0 20428.0 18879.0 13560.0 24552.0 True False 22632.176815492738 21490.867818484396 22586.858681644717 25741.188592132658 23364.069091229103 21346.295195521452 21377.942477314067 18933.9347644133 16272.378898056228 23843.119966243048 0.9492120514234397 0.9013446163468137 0.9473113717341968 1.079606554367754 0.9799082135353014 0.8952811220068269 0.8966084349523399 0.7941047476680845 0.6824769124634095 1.0 14.541285410035618 -7.312067771101174 1.7829984750472152 0.8092872804325494 0.9690413397997594 0.32400596967924744 0.0863438070547816 0.390348900864326 2.4171752597278124 0.047779587562411664 0.02841008644001739 4.874524178386282e-08 7.312067771101174 0.15975405936721 GIFPVLCK ddPTM_A459_Selumetinib_30min_R2 2 GIFPVLCK 8 0 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 153.67 0.011445 7374800.0 73805.0 54385.0 61235.0 70626.0 79669.0 59631.0 80307.0 81658.0 66664.0 60017.0 False True 69703.21356482401 58556.154624663 57295.20676762695 61006.61696335441 69660.2679701034 67844.62897367762 84041.4346253017 81895.61126079036 79998.6627477892 58284.15326710693 1.1959204973843467 1.004666814945557 0.9830323262148496 1.0467101869657585 1.1951836659762658 1.1640321626147088 1.4419259766913535 1.4051093937227828 1.372562836782893 1.0 15.830816065537418 -6.753007031276964 1.7236861577952818 1.3321234745685815 1.052778473802286 0.3740827285672238 0.13162468355721113 0.3155934957430219 1.94038834540698 0.053841194185761755 0.04943327261728244 1.7660092285648175e-07 6.753007031276964 -0.2793450007662954 GIFPVLCKDPVQEAWAEDVDLR ddPTM_A459_Selumetinib_30min_R1 2 GIFPVLCKDPVQEAWAEDVDLR 22 1 P14618;P14618-3;B4DNK4;P14618-2;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 241.11 3.0386999999999996e-36 70976000.0 7133.1 7247.8 7817.6 9023.3 7416.0 6128.4 6397.1 6220.1 4125.0 4391.3 False True 7299.287351403541 6399.224206589191 6756.012859002998 7447.550043318824 6745.2241094011415 6066.753860141992 5914.561596665247 6055.122742267725 6999.823721920178 4954.966129884235 1.4731255794828364 1.2914768817478677 1.3634831564753485 1.5030476189133555 1.3613057955572208 1.2243784722467381 1.1936633756169452 1.2220311064788638 1.4126885105637883 1.0 12.2746594804361 -6.703427457277121 4.332607568366202 1.2225938411532784 1.3998256272777208 0.43383195016402554 0.10764425369299382 0.22620505432251306 8.59369712158411 0.036099098194549165 0.03517255046550854 1.9795776539449228e-07 6.703427457277121 0.17723178612444235 GIGLDESELDS(ph)EAELMR ddPTM_A459_Selumetinib_30min_R1 2 GIGLDESELDSEAELMR 17 0 Q96RS0 Q96RS0 TGS1 Trimethylguanosine synthase 1 GIGLDES(0.002)ELDS(0.998)EAELMR;GIGLDESELDS(1)EAELMR 228.26 2.8596e-16 29183000.0 1413.52 1748.92 1864.5900000000001 1610.19 1763.01 1307.03 1474.6 1325.88 773.06 1043.18 True False 1446.4522657688701 1544.1556333491508 1611.3889194597316 1329.000543509751 1603.546056784696 1293.8824648882878 1363.369734792729 1290.7133553347894 1311.826357931542 1177.082314433684 1.2288454664827626 1.3118501691974471 1.3689687625924452 1.1290633859783694 1.3623057938443257 1.0992285322975044 1.1582620162368777 1.0965361891073655 1.1144729148043362 1.0 10.200999497538753 -7.3649429891498706 0.5006057358812755 1.0142612091110055 1.3069367476200389 0.5829311204325998 0.0768166499810706 0.6457017031126085 0.35330015816825494 0.07252018874700954 0.061314109883342724 4.3157572706221645e-08 7.3649429891498706 0.2926755385090334 GIGTPPNTT(ph)PIK ddPTM_A459_Selumetinib_30min_R2 2 GIGTPPNTTPIK 12 0 O96028-3;O96028;O96028-6;D6RIS1;D6R9V2;O96028-7;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 GIGTPPNT(0.016)T(0.984)PIK;GIGTPPNT(0.031)T(0.969)PIK 122.64 0.0081682 11501800.0 46960.0 43921.0 45434.0 52314.0 54244.0 55453.0 56259.0 56157.0 56527.0 57467.0 True False 44350.15119577445 47289.59947172607 42510.825904798934 45188.742953316374 47429.38377248723 63091.14739778544 58875.154975093596 56320.407572708194 67833.97949634399 55807.778392802546 0.7946947983418424 0.8473657406478117 0.7617365738085267 0.8097212298123716 0.8498704864876709 1.13050813371783 1.0549632447416442 1.0091856224108675 1.2154932779960375 1.0 15.76817859598823 -6.6869165498681875 5.23674383604107 1.0806969632936834 0.8073671795921747 0.8293119338700585 0.0612542051033928 0.07905546716729722 3.881750011358902 0.01988779637485516 0.019659117663844344 2.0562856754349862e-07 6.6869165498681875 -0.2733297837015086 GIGTPPNTTPIKNGS(ph)PEIK ddPTM_A459_Selumetinib_30min_R1 1 GIGTPPNTTPIKNGSPEIK 19 1 O96028-3;O96028;O96028-6;D6RIS1;D6R9V2;O96028-7;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 GIGT(0.006)PPNT(0.237)T(0.237)PIKNGS(0.519)PEIK 56.335 0.02973 21870000.0 2416.0 2679.0 4719.6 4602.5 2756.5 2619.3 2463.8 2238.8 1650.3 1683.3 True False 2472.2880992823525 2365.341434566689 4078.704242907096 3798.759774625124 2507.175061699602 2592.952220134117 2277.9535823832393 2179.419751352708 2800.4385668569357 1899.3679517304972 1.3016372615057934 1.2453308125008886 2.1474007915059454 2.000012567951411 1.3200049308062385 1.365165826753948 1.1993219009027798 1.147444732531713 1.474405506476763 1.0 10.891303700794744 -6.433914442928711 8.11467302627176 1.2547459002364099 1.676754996967408 0.3529842909023426 0.28157605686298526 0.40300664233445105 33.31325442243072 0.09506696817870397 0.10768117555732626 3.682015030914554e-07 6.433914442928711 0.4220090967309982 GIGTPPNTTPIKNGS(ph)PEIK ddPTM_A459_Selumetinib_30min_R2 2 GIGTPPNTTPIKNGSPEIK 19 1 O96028-3;O96028;O96028-6;D6RIS1;D6R9V2;O96028-7;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 GIGTPPNT(0.095)T(0.095)PIKNGS(0.81)PEIK;GIGTPPNT(0.02)T(0.02)PIKNGS(0.961)PEIK 80.41199999999998 0.0034851999999999995 17465300.0 83384.0 104189.0 79754.0 94711.0 71182.0 52527.0 40807.0 45956.0 24189.0 91049.0 True False 78749.85109259911 112179.96127956282 74622.71446958954 81811.19841441208 62239.48078484592 59762.11745736885 42704.60635753652 46089.72435157465 29027.47589712996 88420.1787962878 0.8906321177435271 1.2687144813178386 0.8439557065532927 0.9252548403334241 0.703905846291491 0.6758877698613959 0.4829735354406387 0.5212579863445115 0.32829017416948086 1.0 16.432088031148112 -6.2444004216843805 1.0877067753505256 0.5481209363074417 1.0595052302944572 0.4731184164756872 0.19176910235065497 0.38676360684900374 0.9526172289208925 0.07887001480952147 0.12134444717746762 5.696388202420318e-07 6.2444004216843805 0.5113842939870155 GIITDS(ph)FGR ddPTM_A459_Selumetinib_30min_R1 3 GIITDSFGR 9 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 GIIT(0.007)DS(0.993)FGR;GIIT(0.001)DS(0.999)FGR;GIITDS(1)FGR 88.134 0.031598 61142100.0 7714.8 10290.5 9673.0 10255.2 9690.2 8740.7 9379.1 8154.099999999999 4908.8 7312.9 True False 7894.53982961238 9085.683476076345 8359.459729985665 8464.321833945798 8813.723120943769 8652.776493920617 8671.626935843273 7937.826779750365 8329.875075433154 8251.581948678162 0.9567304643780485 1.1010838324803645 1.0130735878257604 1.0257817090820647 1.0681252607999194 1.0486203188355565 1.0509047828377198 0.9619763615171927 1.0094882565842462 1.0 13.010455016229844 -7.749574502756606 24.993240863981086 0.9892992285691106 1.040370949891715 0.25087150136021286 0.03722598371568781 260.72529869694546 549217.8791861869 0.016595691208487428 0.009486206085904638 1.7800225216890727e-08 7.749574502756606 0.05107172132260451 GIITDS(ph)FGR ddPTM_A459_Selumetinib_30min_R2 3 GIITDSFGR 9 0 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 1 GIIT(0.066)DS(0.934)FGR;GIIT(0.011)DS(0.989)FGR;GIIT(0.001)DS(0.999)FGR 99.973 0.018330000000000003 32544700.0 145361.0 132246.0 146109.0 144267.0 163918.0 121653.0 129481.0 115420.0 123235.0 146771.0 True False 137282.41754618782 142388.84296208835 136708.50601145078 124617.5857255436 143325.15539448714 138409.59649401836 135502.12306173414 115755.85309119045 147885.4434735962 142533.3398731452 0.9631600414918313 0.9989862237762377 0.9591335341831004 0.8743048176409349 1.0055553004093405 0.971068218966896 0.9506696691618337 0.8121317664639955 1.0375498364467879 1.0 17.120939892968778 -7.533071495896669 24.964035330317163 0.9311846667726916 0.9615142735936322 0.0 0.06424297247525713 802.4716787204342 1965379.4862437 0.029151763086991876 0.01685172109788058 2.930410785532495e-08 7.533071495896669 0.030329606820940547 GILAADES(ph)TGSIAK ddPTM_A459_Selumetinib_30min_R1 5 GILAADESTGSIAK 14 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GILAADES(0.968)T(0.031)GS(0.001)IAK;GILAADES(0.988)T(0.012)GS(0.001)IAK;GILAADES(0.645)T(0.028)GS(0.327)IAK;GILAADES(0.93)T(0.07)GSIAK;GILAADES(0.497)T(0.497)GS(0.006)IAK 260.73 7.937899999999999e-36 73179500.0 15688.0 22792.100000000002 18145.7 22212.4 17467.199999999997 17306.0 18901.0 17627.6 9439.7 15448.999999999998 True False 16053.499876465885 20123.590336240173 15681.613607195379 18333.421318388497 15887.294844084628 17131.917352590775 17475.282352717608 17160.05878548552 16018.481451590282 17432.029636003346 0.9209197214367795 1.1544031737232592 0.8995862177062426 1.0517089347142605 0.9113852589644358 0.9827838588116709 1.0024812209259288 0.9843982108683368 0.9189108661510313 1.0 14.089452933828087 -5.2902587852694545 24.999794574930622 0.9709471951657536 1.0376616259622087 0.13736919010862692 0.06876556173811531 1157.841721455892 1004384.5117451905 0.016464446242549252 0.034282048366394785 5.125558736930088e-06 5.2902587852694545 0.06671443079645512 GILAADES(ph)TGSIAK ddPTM_A459_Selumetinib_30min_R2 4 GILAADESTGSIAK 14 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GILAADES(0.913)T(0.087)GSIAK;GILAADES(0.985)T(0.015)GSIAK;GILAADES(0.774)T(0.225)GS(0.001)IAK;GILAADES(0.917)T(0.083)GSIAK 212.03 3.1148e-06 54963400.0 256041.0 249055.0 258843.0 246134.0 265722.0 182273.0 186597.0 201610.0 177554.0 230841.0 True False 241811.2662333323 268156.71766195516 242189.32318694927 212610.1245951672 232339.62677517982 207379.45124044767 195274.13023494123 202196.65172166776 213069.7612732651 224176.0205330522 1.0786669584835458 1.1961882320166288 1.0803533875347797 0.9484070780167153 1.0364160547712282 0.9250741928032037 0.8710750140475007 0.9019548622590353 0.9504574163044811 1.0 17.774272439876093 -5.781919842150044 1.287083035765663 0.9298142259881013 1.1486376998328793 0.6761871958123022 0.05380799230197196 0.26316852358879134 0.8678701384535643 0.01898806691286805 0.04662695824013867 1.652266729404545e-06 5.781919842150044 0.21882347384477807 GILAADEST(ph)GSIAK ddPTM_A459_Selumetinib_30min_R2 4 GILAADESTGSIAK 14 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GILAADES(0.231)T(0.414)GS(0.354)IAK;GILAADES(0.33)T(0.67)GSIAK;GILAADES(0.304)T(0.596)GS(0.1)IAK;GILAADES(0.307)T(0.679)GS(0.014)IAK 249.39 4.7832999999999996e-27 63083300.0 183073.0 166529.0 184875.0 186142.0 182770.0 138518.0 131426.0 157459.0 133581.0 185756.0 True False 172898.535559285 179301.23882486904 172980.3437766803 160789.13848713966 159808.798615469 157597.59715879112 137537.5694156786 157917.17962125925 160300.93256498897 180392.74162795037 0.9584561662457476 0.9939492975535984 0.9589096668503564 0.8913282044283023 0.8858937292780074 0.873636021807502 0.7624340545771066 0.8754076144978955 0.8886218542850266 1.0 17.460781765202896 -5.799822428712941 2.195360318157955 0.8684555832589987 0.9783480819872573 0.3418175393074645 0.05475790293799803 0.30148306541873543 2.9663437880453727 0.016433550862424012 0.030232107839470928 1.585541344990061e-06 5.799822428712941 0.10989249872825857 GILAADESTGS(ph)IAK ddPTM_A459_Selumetinib_30min_R1 2 GILAADESTGSIAK 14 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GILAADEST(0.006)GS(0.993)IAK;GILAADES(0.002)T(0.044)GS(0.954)IAK 236.4 2.5399e-19 35393000.0 5447.6 8591.2 6296.4 7670.1 5930.4 6847.700000000001 7056.5 6336.1 3311.6000000000004 5609.9 True False 5574.518480815625 7585.338310059479 5441.383463649512 6330.6610206088335 5393.996367097161 6778.818355214136 6524.222523779257 6168.046045446619 5619.54333030566 6329.985310053413 0.8806526725997389 1.1983184697146594 0.859620235612142 1.000106747570859 0.852134105039755 1.0709058588884681 1.0306852550538077 0.9744171184173843 0.8877656195158282 1.0 12.627986436268676 -5.2934207743913495 24.997778344355503 0.9626840877737634 1.0394859586782317 0.09381765567483435 0.09908519061928446 1391.7772206498244 1087859.6580425147 0.024689472717638477 0.05140184949999535 5.0883763522544885e-06 5.2934207743913495 0.07680187090446833 GILAADESTGS(ph)IAKR ddPTM_A459_Selumetinib_30min_R1 3 GILAADESTGSIAKR 15 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GILAADES(0.007)T(0.003)GS(0.99)IAKR;GILAADES(0.001)T(0.001)GS(0.998)IAKR;GILAADES(0.001)TGS(0.999)IAKR 225.21 5.5615e-10 34703000.0 5142.6 7445.0 8044.800000000001 8576.5 6664.7 6247.8 6579.1 5748.4 3191.53 4692.4 True False 5262.412574242312 6573.335938913399 6952.360346923265 7078.775275844077 6061.879061748354 6184.952804548517 6082.8331901362 5595.933758565262 5415.793309871487 5294.7152478466 0.9938990725483443 1.2414899822208239 1.3130754009388592 1.3369510813113261 1.144892364931951 1.1681370036025986 1.1488499202313351 1.056890408004693 1.0228677192931444 1.0 12.370337382181647 -7.652692430251957 1.0640629339058456 0.9999781570476192 1.2201586789692738 0.43686652463813924 0.08924613701501073 0.5095112408255714 1.051320567723591 0.07907615282384789 0.033667162362683176 2.2248850086695425e-08 7.652692430251957 0.2201805219216546 GILAADESTGS(ph)IAKR ddPTM_A459_Selumetinib_30min_R2 1 GILAADESTGSIAKR 15 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GILAADES(0.013)T(0.314)GS(0.673)IAKR 90.706 0.0078491 8349500.0 56989.0 56031.0 66328.0 64380.0 65110.0 41027.0 37019.0 33880.0 33685.0 55629.0 True False 53821.779525042395 60328.39753193879 62060.52869246604 55611.332938305386 56930.29970921475 46678.09684397496 38740.4568517569 33978.58519086405 40422.941237538646 54022.846228500115 0.9962781171764392 1.1167200868456304 1.148783024684945 1.0294039803657598 1.0538189614893112 0.8640436426940723 0.717112472895201 0.6289669568157336 0.7482564148242388 1.0 15.721282030717516 -6.881204636704057 2.5172056782363943 0.7436851628481923 1.0789668417771956 0.6702216570143444 0.09788743738015909 0.15090174386556612 1.9441600479451622 0.03760596634050912 0.0323637128535266 1.3146052528822227e-07 6.881204636704057 0.3352816789290033 GILAADESTGSIAK ddPTM_A459_Selumetinib_30min_R1 1 GILAADESTGSIAK 14 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 234.65 9.2674e-13 17516000.0 4056.1 3928.0 3566.7 4105.1 3078.4 4115.8 3994.3 3353.5 2404.4 3070.8 False True 4150.59923820329 3468.10793392234 3082.361730480706 3388.2213472707417 2799.959263535664 4074.398788847402 3693.0067351706202 3264.5542862968127 4080.0911895720888 3464.9670921250004 1.1978755144995632 1.0009064564579786 0.8895789335160323 0.9778509455317246 0.8080767260096836 1.1758838339641051 1.0658129318353113 0.9421602570818997 1.1775266780585336 1.0 11.75862593536411 -6.784480498863357 24.99744064914383 1.0682576922606914 0.9717332880803164 0.15397694250507987 0.11386415538099513 484.59509712813883 525736.1084386265 0.040553137193919064 0.035786588145100905 1.6425534136382493e-07 6.784480498863357 -0.096524404180375 GILAADESTGSIAK ddPTM_A459_Selumetinib_30min_R2 1 GILAADESTGSIAK 14 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 196.24 0.001649 12632000.0 56196.0 45157.0 55577.0 61090.0 54345.0 45835.0 40503.0 48499.0 35408.0 44406.0 False True 53072.85129041187 48620.39669735969 52001.236327662315 52769.43661387197 47517.69524953576 52148.35520129653 42386.469755171944 48640.12406055832 42490.58938218104 43123.88339935598 1.2307066782210172 1.1274586810075131 1.2058569921937714 1.2236707934021553 1.1018881302847925 1.2092685326682644 0.982900110424771 1.1279161389552574 0.9853145411021959 1.0 15.396199481311568 -7.314306834422412 0.8965991202375022 1.008790982222958 1.1919581212865493 0.6028410568687219 0.059827801430431864 0.41371692193307485 0.639377551694748 0.044506459389762526 0.024859051130592974 4.849457589248809e-08 7.314306834422412 0.1831671390635914 GILFVGS(ph)GVSGGEEGAR ddPTM_A459_Selumetinib_30min_R2 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 GILFVGS(0.55)GVS(0.45)GGEEGAR 116.43 0.0016224 1693500.0 6608.9 6974.2 9185.2 7748.4 8412.8 7088.3 7513.8 5499.4 6243.1 7927.4 True False 6241.60379552287 7509.098714412519 8594.234232089604 6693.054553264454 7355.90885261375 8064.648983819137 7863.206588312243 5515.40234352532 7491.894446788705 7698.515364141218 0.8107542169228535 0.9753956911470256 1.1163495590488186 0.8693954920762926 0.9554970672497078 1.047558990579317 1.0213925953747054 0.7164241522742707 0.9731609397943233 1.0 12.910364537832612 GILFVGSGVS(ph)GGEEGAR ddPTM_A459_Selumetinib_30min_R1 2 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 GILFVGSGVS(1)GGEEGAR;GILFVGS(0.001)GVS(0.999)GGEEGAR 197.73 7.6445e-08 10558300.0 2388.1000000000004 3049.5 3477.7 3284.9 3212.3999999999996 2773.9 3110.3999999999996 3080.1000000000004 1546.97 2818.8 True False 2443.738083566303 2692.4631223259103 3005.4474416387006 2711.253880209899 2921.8389871952836 2745.9970844996865 2875.7800238025934 2998.4057424251732 2625.0951037815403 3180.620437437133 0.7683211913004646 0.8465213549641377 0.944924897753728 0.8524292456582973 0.9186380596704052 0.8633526503754545 0.9041569342740648 0.9427109588848696 0.8253405759716422 1.0 11.63509250133686 -1.522878949064731 0.02214135465460834 1.5625066344203196 2.4007448285476912e-11 0.3928606389763938 0.05037786688177101 2840.812127707775 4.861165430560527 123.2404932845334 236.8538947640275 0.02999998592307611 1.522878949064731 -1.562506634396312 GILFVGSGVS(ph)GGEEGAR ddPTM_A459_Selumetinib_30min_R2 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 GILFVGS(0.193)GVS(0.807)GGEEGAR 74.96600000000002 0.022618 1594200.0 8615.3 8472.1 9522.9 10338.0 9907.6 6901.0 6630.1 9564.3 6282.9 9556.2 True False 8136.496115778448 9121.882827904885 8910.206981749569 8929.946565955284 8662.918712932205 7851.55010895925 6938.412787293916 9592.130529544896 7539.655558893626 9280.287676010586 0.8767504197969183 0.9829310411879606 0.9601218510480368 0.9622488954775692 0.9334752343212085 0.8460459829553988 0.747650614886607 1.033602714099092 0.8124376982820835 1.0 13.179953812247815 -6.605255907893398 6.588329990062717 0.88153360457412 0.9490665181581015 0.09903895888380887 0.08234227925176175 0.45035224577963745 29.330003726193098 0.026549919573062186 0.026539050622853323 2.481670350863057e-07 6.605255907893398 0.0675329135839815 GILFVGSGVSGGEEGAR ddPTM_A459_Selumetinib_30min_R2 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 106.79 0.034818 7444500.0 23717.0 25937.0 29685.0 25534.0 27678.0 20139.0 19364.0 21744.0 18112.0 25824.0 False True 22398.904086673407 27926.28449940027 27775.099418584243 22056.22515139314 24200.84219554056 22912.964446359994 20264.464369038076 21807.27144008701 21734.906091563018 25078.394021190154 0.8931554416023333 1.113559523620363 1.1075310243197987 0.8794911321975637 0.9650076546006854 0.9136535787339307 0.8080447397036462 0.8695641125050039 0.8666785470073549 1.0 14.614157342846914 -5.772619718059139 24.99883341412318 0.894316203078186 1.045629750242311 0.40763138446170044 0.07567958186248484 187.61834148799414 419507.97921658366 0.02141164213442863 0.032086820641179147 1.6880304711463305e-06 5.772619718059139 0.15131354716412504 GILHLS(ph)PDVYQEMEASR ddPTM_A459_Selumetinib_30min_R1 2 GILHLSPDVYQEMEASR 17 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3;E5RJ67;E5RJN7 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GILHLS(1)PDVYQEMEASR;GILHLS(1)PDVYQEMEASR 160.79 1.6059e-05 16049400.0 6238.8 6827.3 8674.9 8783.8 8471.099999999999 7022.3 7944.5 7624.6 4293.8 6319.2 True False 6384.151901408425 6027.956542074341 7496.896227814807 7249.874222347014 7704.890500694171 6951.662037738253 7345.239968846354 7422.37083980876 7286.264993255963 7130.330874220492 0.8953514239416497 0.8453964687484905 1.0514093048500206 1.0167654699670008 1.0805796584490888 0.9749424199754586 1.0301401293175412 1.0409574212950103 1.0218691280651853 1.0 12.799753309370725 -5.261857961309252 24.99999747211146 1.0283348486306256 0.87037393624005 0.8220736226419207 0.029157440562561816 12.601386175396557 752685.8324445738 0.007186115788304603 0.01662884828572637 5.471948970999619e-06 5.261857961309252 -0.15796091239057564 GILHLS(ph)PDVYQEMEASR ddPTM_A459_Selumetinib_30min_R2 2 GILHLSPDVYQEMEASR 17 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3;E5RJ67;E5RJN7 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GILHLS(1)PDVYQEMEASR;GILHLS(0.995)PDVY(0.005)QEMEASR 102.67 0.0023083 6659300.0 42938.0 41429.0 50657.0 54099.0 46138.0 38482.0 37289.0 45908.0 36620.0 40844.0 True False 40551.67785443279 44606.47108476903 47397.78377117135 46730.62287401967 40341.73196104667 43782.54619518475 39023.012386751725 46041.5846795215 43945.02324829048 39664.72759454343 1.0223611836933773 1.1245878590353768 1.1949605265331946 1.17814052202008 1.017068171334079 1.103815627898269 0.9838215148140842 1.1607689620401003 1.107911888302893 1.0 15.27556902057371 -6.2574711569584744 24.98904437395236 1.068428230249833 1.1342641880011373 0.19581086083212051 0.0663639270797204 623.0158477285286 3923316.0303695467 0.020363661612258444 0.025284535396655282 5.527501168270789e-07 6.2574711569584744 0.06583595775130435 GILHTDSQSQS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 GILHTDSQSQSLR 13 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 GILHTDSQS(0.002)QS(0.998)LR 122.12 0.0017924 3850700.0 22808.0 17800.0 22944.0 23788.0 33222.0 30381.0 22302.0 23562.0 24212.0 28646.0 True False 21540.422667658087 19165.202763979054 21467.808019538363 20548.033363411134 29048.355351551687 34565.70697874091 23339.087190574635 23630.561519100916 29055.07653980366 27818.915548753605 0.7743084963145942 0.6889270263030699 0.7716982346747231 0.7386353119121413 1.0441943827984037 1.242525321239188 0.8389646659544324 0.8494422249381917 1.0444359877682379 1.0 14.763778560647086 -6.255646024736235 24.523776134633394 0.9994810005156843 0.741523727306171 0.5824287521348307 0.10776283292114229 294.1643082183407 1245221.7231774062 0.03483652257989716 0.04371963340048791 5.550779494486142e-07 6.255646024736235 -0.25795727320951334 GILILPAHTTLS(ph)VNSAGSPESAPLGPR ddPTM_A459_Selumetinib_30min_R1 1 GILILPAHTTLSVNSAGSPESAPLGPR 27 0 Q86US8 Q86US8 SMG6 Telomerase-binding protein EST1A 1 GILILPAHT(0.016)T(0.303)LS(0.663)VNS(0.014)AGS(0.003)PESAPLGPR 107.7 1.1796e-09 10501000.0 1266.2 1521.8 1449.9 1493.8 2447.5 1352.9 1883.6 1193.5 247.68 983.04 True False 1295.6999964036906 1343.6269485343735 1253.0115437306133 1232.9358720988614 2226.12405714122 1339.2910543349171 1741.518535504941 1161.8445029656318 420.2948701685304 1109.2227596204757 1.1681152276816054 1.2113229167729123 1.1296302143668018 1.1115313505834614 2.006922448925314 1.207413968672226 1.5700349820633028 1.0474401943962643 0.37890934577679936 1.0 10.1153334084373 -8.012096246206003 6.673359220109763 0.6927450067981743 1.3403002907726895 0.446169874199535 0.2917261610982478 0.13502064895668783 28.84788611102024 0.18189242176102713 0.07585618101126272 9.72531672209548e-09 8.012096246206003 0.6475552839745152 GILILPAHTTLSVNSAGS(ph)PESAPLGPR ddPTM_A459_Selumetinib_30min_R2 1 GILILPAHTTLSVNSAGSPESAPLGPR 27 0 Q86US8 Q86US8 SMG6 Telomerase-binding protein EST1A 1 GILILPAHTT(0.002)LSVNS(0.074)AGS(0.886)PES(0.037)APLGPR 121.19 1.4419000000000002e-09 0.0 8767.5 10030.0 14170.0 11421.0 12970.0 7976.3 9471.1 9078.3 7849.7 10986.0 True False 8280.237449083323 10799.268748466855 13258.317627129483 9865.440097676079 11340.592646728837 9074.96292335773 9911.524916628616 9104.716350006523 9419.859338943359 10668.805634944038 0.7761166275222667 1.0122284647398117 1.2427180774297637 0.9246995807443845 1.0629674056095337 0.8506072032687596 0.9290191663221359 0.8533960277789128 0.8829347596407655 1.0 13.381111056087626 -6.762868760233488 24.999803019194612 0.8956429131032111 1.013102035066153 0.15373851557365525 0.11626127224746154 66.94644984325284 1170876.596999444 0.04036343734760615 0.03752798722479732 1.7263595030116478e-07 6.762868760233488 0.11745912196294195 GILLEDGSES(ph)PAKR ddPTM_A459_Selumetinib_30min_R1 2 GILLEDGSESPAKR 14 1 Q08999;Q08999-2 Q08999 RBL2 Retinoblastoma-like protein 2 1 GILLEDGS(0.23)ES(0.77)PAKR;GILLEDGS(0.077)ES(0.923)PAKR 144.88 0.00094493 19444100.0 3453.6 4428.4 5279.3 5125.1 4515.2 4707.1 4489.1 4434.9 2750.3999999999996 4248.5 True False 3534.0621604642133 3909.9208692926927 4562.400057119132 4230.0974950420905 4106.800957223304 4659.750847704843 4150.483572804856 4317.272045414562 4667.227918731937 4793.83635889444 0.7372095949639889 0.8156141713177717 0.9517221105501643 0.8824033985210209 0.8566835932151883 0.9720296019406637 0.8657958390891016 0.9005881140277837 0.9735893279027777 1.0 12.226964947040688 -5.027372543881241 3.19683737243155 0.9171892862356903 0.7417361635672105 0.6262831704304732 0.04737657822441094 0.1617190767539715 3.215453068489804 0.01193834335004806 0.052368014195227096 9.389175484109522e-06 5.027372543881241 -0.1754531226684798 GILLEDGSES(ph)PAKR ddPTM_A459_Selumetinib_30min_R2 1 GILLEDGSESPAKR 14 1 Q08999;Q08999-2 Q08999 RBL2 Retinoblastoma-like protein 2 1 GILLEDGS(0.082)ES(0.918)PAKR 65.51100000000001 0.036872 16807000.0 74399.0 69403.0 73604.0 79390.0 63903.0 48912.0 62974.0 62696.0 49483.0 63282.0 True False 70264.20142279436 74725.98693418181 68868.3987739759 68576.94504461117 55874.9338399316 55649.18402107157 65902.4157806136 62878.43498011847 59380.98267053955 61454.88423361813 1.1433460871179577 1.2159487055595801 1.120633447329843 1.1158908832033403 0.9092024911726366 0.9055290676250167 1.0723706765126815 1.023164159598589 0.9662532671090107 1.0 15.907240055397137 -6.087229702681938 4.461798735677401 0.9819326867790269 1.1598804607801283 0.723021193713621 0.05181637929748659 0.130416857379716 4.5667971431928995 0.016907551830351718 0.022551906721383984 8.180320084080724e-07 6.087229702681938 0.1779477740011014 GILSLPHQAS(ph)PVSR ddPTM_A459_Selumetinib_30min_R1 1 GILSLPHQASPVSR 14 0 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 GILSLPHQAS(0.994)PVS(0.006)R 161.24 0.0001883 33738000.0 4139.9 4733.6 4902.0 5304.8 4923.0 4386.8 4878.7 4330.0 1907.6 3295.8 True False 4236.351615156876 4179.387911409063 4236.335324758579 4378.416263428862 4477.715519226245 4342.672774895713 4510.695731136094 4215.154334177786 3237.0578744084673 3718.8480338105933 1.1391569584563024 1.123839391502795 1.1391525779604745 1.1773582097525048 1.2040598267302853 1.1677467687341623 1.212928221354105 1.1334569995479602 0.8704463976420005 1.0 11.860640079843156 -8.174207351037708 5.576773296962189 0.9371170266905026 1.1656396150794373 0.8394332276850609 0.03982491603548018 0.07518572360583109 3.640267859211694 0.02816734726530252 0.01018752302820084 6.695648537640309e-09 8.174207351037708 0.2285225883889347 GILSLPHQAS(ph)PVSR ddPTM_A459_Selumetinib_30min_R2 4 GILSLPHQASPVSR 14 0 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 GILSLPHQAS(0.99)PVS(0.01)R;GILSLPHQAS(0.986)PVS(0.014)R;GILSLPHQAS(0.999)PVS(0.001)R;GILSLPHQAS(0.989)PVS(0.011)R 141.1 0.00036848 95871500.0 230259.0 196386.0 248313.0 259620.0 286440.0 208979.0 204677.0 217484.0 200755.0 227074.0 True False 217462.12657980894 211448.1747194824 232336.8119227529 224259.30813051973 250454.84639390968 237763.96032751724 214194.88605978133 218116.84243358552 240911.60956336872 220517.7836108938 0.986143262547584 0.9588713039696842 1.0535967127835546 1.016966996758084 1.135758043151024 1.078207645815335 0.9713270401707407 0.9891122559913591 1.0924815478304466 1.0 17.750535480753364 -5.262941790197784 24.862345551170066 1.042990097921279 0.9725072795891652 0.24953396049606746 0.048315337296522314 170.85168989387282 2827376.2628662516 0.013279259245259334 0.030259183031990548 5.458310155695846e-06 5.262941790197784 -0.07048281833211378 GINGGPSRMS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 GINGGPSRMSPK 12 1 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GINGGPS(0.009)RMS(0.991)PK 70.27199999999999 0.035062 14354000.0 1576.0 1032.4 5260.0 4903.5 2508.3 2017.6 1541.1 1627.4 1481.1 1027.1 True False 1612.7177336378256 911.5261280502614 4545.720891111815 4047.195775094904 2281.4247078763337 1997.3047758342286 1424.8535862532708 1584.236065459798 2513.3185247359934 1158.9382898012202 1.3915475464309985 0.7865182607838467 3.9223148731167488 3.4921581336216567 1.9685471849132201 1.7233918263040597 1.229447330191895 1.3669718909119177 2.168638785044435 1.0 10.17858803360528 -6.667618459035583 3.4187600344792983 1.493610838129884 2.4189752644671074 0.1807799800323322 0.8948518245946655 0.4671104269864366 10.749797563038852 0.3451148206238491 0.338903240172748 2.1497182378980695e-07 6.667618459035583 0.9253644263372234 GIPHLVTHDAR ddPTM_A459_Selumetinib_30min_R1 2 GIPHLVTHDAR 11 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 ; 185.6 1.0722e-05 77186000.0 14788.800000000001 16075.599999999999 18378.5 19036.8 18134.6 13371.8 16002.9 14892.5 7929.1 12677.6 False True 15133.3502660045 14193.46127865632 15882.800645874246 15712.3802449937 16494.32863192367 13237.291832622981 14795.788368991303 14497.502522342407 13455.103581449037 14304.893450281319 1.0579142248491817 0.9922102061079799 1.1103054140932378 1.0983919803110942 1.1530549800494525 0.9253680832108999 1.0343165728857862 1.013464558315693 0.9405944635808825 1.0 13.80422113136481 -6.765872585640286 24.999998827249893 0.9868132679220437 1.079807666123861 0.5087787571363105 0.048832117903661446 108.22124759551889 610281.9123019939 0.017736893564865314 0.01616984480922638 1.7144602261960406e-07 6.765872585640286 0.09299439820181721 GIPHS(ph)ASPVSPDGVQIPLK ddPTM_A459_Selumetinib_30min_R2 1 GIPHSASPVSPDGVQIPLK 19 0 Q6PJF5;Q6PJF5-2 Q6PJF5 RHBDF2 Inactive rhomboid protein 2 1 GIPHS(0.605)AS(0.392)PVS(0.003)PDGVQIPLK 81.226 0.0038726 5278200.0 46774.0 19120.0 38398.0 39365.0 25080.0 24010.0 70105.0 47863.0 44993.0 26872.0 True False 44174.48833115751 20586.4425195101 35927.514484581356 34003.419091587326 21929.22618195523 27317.159558920674 73365.02141042215 48002.27340585378 53992.85720945755 26096.135538159117 1.6927597676891006 0.7888693898530509 1.3767369667453746 1.3030059198560557 0.8403246584111729 1.0467894573499632 2.811336617375551 1.839439917671426 2.0689981905752446 1.0 14.67154855980363 -7.21994062609873 24.997566323459044 1.9998976088409046 1.1570177971900923 0.37007420329677 0.47888801049855706 456.42868508929257 274938.83600403793 0.17252382922636755 0.13363514794138562 6.026419697115595e-08 7.21994062609873 -0.8428798116508123 GIPLATGDTS(ph)PEPELLPGAPLPPPK ddPTM_A459_Selumetinib_30min_R1 2 GIPLATGDTSPEPELLPGAPLPPPK 25 0 K7ENA8;O75821;K7EL20;K7ER90;K7EL60 K7ENA8 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 GIPLAT(0.011)GDT(0.177)S(0.812)PEPELLPGAPLPPPK;GIPLAT(0.002)GDT(0.164)S(0.834)PEPELLPGAPLPPPK 145.33 7.434099999999999e-10 255560000.0 9732.6 12628.8 10438.9 11531.2 11127.8 10453.900000000001 11081.7 11011.3 5791.6 9562.7 True False 9959.350643657048 11150.214225030157 9021.354716773225 9517.492387432318 10121.292454772652 10348.743257381755 10245.798447072144 10719.24455425677 9827.92219827221 10790.16569358594 0.9230025679380662 1.0333682115426868 0.8360719355900013 0.8820524779420075 0.9380108463755206 0.9590903004884733 0.9495496860778156 0.9934272427928212 0.9108221761704993 1.0 13.397429398543993 -6.618559379866784 4.009334092993791 0.9612809366133267 0.9198500767880124 0.1379649864121465 0.05158287060703263 0.5216486739531541 15.738575416360675 0.01817406341831632 0.018197101990984507 2.406803421069081e-07 6.618559379866784 -0.04143085982531425 GIPNMLLS(ph)EEETES ddPTM_A459_Selumetinib_30min_R1 1 GIPNMLLSEEETES 14 0 F5GYQ2;Q9UI30-2;Q9UI30 F5GYQ2 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 GIPNMLLS(0.593)EEET(0.203)ES(0.203) 78.814 0.037324 5321200.0 1293.7 1604.6 1823.6 1944.1 1819.7 1443.6 1486.2 1509.5 968.67 1361.1 True False 1323.8406928980055 1416.7326860416981 1575.965136317778 1604.5994302767415 1655.108456294129 1429.078694683927 1374.0947374535147 1469.4631564529711 1643.7622411424027 1535.8104432367247 0.8619818277234836 0.922465850053689 1.0261456049201143 1.0447900242786758 1.0776775633886062 0.9305046081547276 0.8947033427885841 0.956799820527378 1.0702897928458992 1.0 10.584784447675407 -5.023530036387569 3.5637204654025916 0.9963945823493416 0.8678394508337736 0.38793681308862893 0.056361898185838206 0.26609045303756407 6.974010028077639 0.016270252680841212 0.0660274882169965 9.472616683540149e-06 5.023530036387569 -0.12855513151556808 GIPNMLLSEEET(ph)ES ddPTM_A459_Selumetinib_30min_R1 1 GIPNMLLSEEETES 14 0 F5GYQ2;Q9UI30-2;Q9UI30 F5GYQ2 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 GIPNMLLS(0.016)EEET(0.685)ES(0.299) 103.75 0.015591999999999996 4940000.0 1454.3 1654.5 1764.5 1584.4 1455.4 1151.7 1472.2 1383.2 669.25 1178.5 True False 1488.1823604248038 1460.790370843817 1524.8905917047146 1307.7142828714923 1323.7593269717402 1140.114943659933 1361.15076872498 1346.5130427331899 1135.6683699139573 1329.7719545621046 1.1191259939865885 1.0985269811355414 1.1467309010941373 0.9834124402947902 0.995478452098695 0.8573762890309822 1.0235971393856087 1.012589442959487 0.8540324271524693 1.0 10.376963140741037 -5.8371479581855725 4.9728947262731955 0.9591465729507149 1.1190770561371883 0.6235582287743529 0.05731402049033705 0.13274882052560558 5.9279989170185186 0.016168932198572288 0.024814719856063715 1.454963310050741e-06 5.8371479581855725 0.1599304831864734 GIQLS(ph)PGVGSSAGPPGDLEDDEGLKHLQQEAEK ddPTM_A459_Selumetinib_30min_R2 1 GIQLSPGVGSSAGPPGDLEDDEGLKHLQQEAEK 33 1 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 GIQLS(0.63)PGVGS(0.289)S(0.08)AGPPGDLEDDEGLKHLQQEAEK 84.88799999999998 1.3325e-08 11036000.0 62142.0 61582.0 58954.0 63256.0 57692.0 37303.0 38568.0 37738.0 28094.0 59744.0 True False 58688.39641413581 66305.14138266061 55160.96382426189 54640.42367731357 50444.215186976115 42441.14964708115 40361.488421042166 37847.8113321378 33713.585011946314 58019.03548644609 1.0115369192555104 1.1428170224951473 0.950739069717009 0.9417671841524873 0.8694424987254478 0.7315038812907513 0.6956594173384884 0.6523343763785849 0.5810779984410839 1.0 15.824238691795335 -6.277927795134325 1.083979340896071 0.6992757067505798 1.0649943827108923 0.5854732559046028 0.11187695884921622 0.3171441019532186 0.7783027020590706 0.047084682259044684 0.06994665775867502 5.273175248118006e-07 6.277927795134325 0.3657186759603125 GIQLSPGVGS(ph)SAGPPGDLEDDEGLKHLQQEAEK ddPTM_A459_Selumetinib_30min_R2 1 GIQLSPGVGSSAGPPGDLEDDEGLKHLQQEAEK 33 1 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 GIQLS(0.209)PGVGS(0.396)S(0.396)AGPPGDLEDDEGLKHLQQEAEK 87.28 9.977600000000002e-09 11938000.0 35151.0 34026.0 36068.0 39395.0 35324.0 25376.0 24800.0 27763.0 18639.0 37327.0 True False 33197.448140601984 36635.68478916584 33747.42414786918 34029.33303983443 30886.283319433285 28871.313659607313 25953.24914026773 27843.78573358793 22367.320817173317 36249.27252280684 0.9158100516283535 1.0106598626528542 0.9309821080308969 0.9387590611211386 0.8520525011915939 0.7964660157370729 0.7159660686690694 0.7681198489175072 0.6170419227889482 1.0 15.145664421897154 -6.510938633499373 1.6277010283306252 0.7558525344897347 0.9583058247126133 0.4193419896569093 0.09291437676202896 0.3151285667079292 1.6946097971806402 0.03435698901731875 0.038054923768307596 3.0836236403887425e-07 6.510938633499373 0.2024532902228786 GIQLYDTPYEPEGQSVDSDS(ph)ESTVSPR ddPTM_A459_Selumetinib_30min_R2 1 GIQLYDTPYEPEGQSVDSDSESTVSPR 27 0 Q15464 Q15464 SHB SH2 domain-containing adapter protein B 1 GIQLYDTPYEPEGQS(0.063)VDS(0.115)DS(0.28)ES(0.239)T(0.239)VS(0.063)PR 60.527 0.01739 0.0 4047.3 4134.6 4318.9 5062.8 7029.0 3620.5 4353.7 4563.6 2827.2 5636.6 True False 3822.3672686255977 4451.710525165607 4041.026676062772 4373.237906182863 6145.954179942716 4119.191011373276 4556.155676692887 4576.879320455348 3392.718998568185 5473.856712354411 0.6982950905526214 0.8132676390885725 0.7382412234032791 0.7989317470281113 1.1227831678661577 0.7525207961831234 0.832348363523969 0.8361342945140309 0.6198041302233707 1.0 12.4183419548269 -11.989541192036375 2.3343636871344775 3.3379000595873616 0.8097413762859028 0.18251776399051445 0.12498600590276256 17435060.450953785 940552.3435611371 219893514.31667155 0.03242992984096067 1.0243746156459394e-12 11.989541192036375 -2.528158683301459 GIRDDIEEEDDQEAYFR ddPTM_A459_Selumetinib_30min_R1 1 GIRDDIEEEDDQEAYFR 17 1 Q86XP3-2;Q86XP3;A0A0A0MSJ0;J3KRE3 Q86XP3-2 DDX42 ATP-dependent RNA helicase DDX42 0 89.506 0.026752 3776300.0 966.34 1073.7 983.45 917.98 996.85 882.91 988.06 1100.0 404.29 626.57 False True 988.8538418296808 947.990704850412 849.9028917041667 757.6720256187663 906.6850935081613 874.0287270181396 913.5298387083302 1070.8244266964346 686.0506018266931 706.9963628086361 1.39866892370044 1.340870695691268 1.202131915258822 1.071677402425119 1.2824466167071007 1.236256327466729 1.2921280600075686 1.5146109414798734 0.9703735944287842 1.0 9.46555898278473 -8.294460016666804 24.846702068049947 0.9851865171844633 1.2813961305708854 0.5463714027806432 0.11159606063879277 565.5588980245047 425555.146202588 0.11332059182531425 0.02926721863731264 5.076214710621074e-09 8.294460016666804 0.29620961338642215 GIRDDIEEEDDQEAYFR ddPTM_A459_Selumetinib_30min_R2 1 GIRDDIEEEDDQEAYFR 17 1 Q86XP3-2;Q86XP3;A0A0A0MSJ0;J3KRE3 Q86XP3-2 DDX42 ATP-dependent RNA helicase DDX42 0 114.63 0.0027413 0.0 7276.1 7580.3 8503.7 7809.3 8026.7 6688.3 6796.0 6775.1 6624.3 8304.5 False True 6871.723490536084 8161.684635493845 7956.58120012851 6745.659868206093 7018.31418639155 7609.552614657606 7112.027466018523 6794.814419321812 7949.345098406633 8064.727507317752 0.8520713792624534 1.0120223687766408 0.986590209391314 0.836439899808795 0.8702481491188996 0.9435597926591902 0.8818682912181757 0.8425349043915434 0.985692956295619 1.0 12.977410072787858 -8.42137625154055 7.504430574425203 0.9997420435835283 0.9069880454955395 0.2811487921939999 0.05730841529713229 0.3548353194937631 21.60932044472295 0.05789893344571219 0.014973185573958624 3.789865072946978e-09 8.42137625154055 -0.09275399808798879 GIS(ph)HVIVDEIHER ddPTM_A459_Selumetinib_30min_R2 4 GISHVIVDEIHER 13 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 GIS(1)HVIVDEIHER;GIS(1)HVIVDEIHER;GIS(1)HVIVDEIHER;GIS(1)HVIVDEIHER 128.74 0.0011878 10138900.0 4090.05 2520.29 8111.8 7670.200000000001 9732.5 5154.77 5808.76 9476.1 7223.22 6688.33 True False 3862.741394767405 2713.5881389903802 7589.895619460055 6625.505528166983 8509.816340346068 5864.792777156914 6078.878849839578 9503.673882147194 8668.065833629633 6495.220534531703 0.5947051950324429 0.41778229462166006 1.168535476064059 1.0200585943067864 1.310165881990274 0.9029397456140044 0.9359003004626781 1.4631795535842258 1.334529872780461 1.0 12.66516279550442 -5.264944652771329 24.999404694772906 1.1442204568427692 0.5062437133335578 0.6692046891683665 0.1787629590216141 164.1930150672397 1171023.6726781353 0.04887167483351484 0.10865812313311475 5.433195686519581e-06 5.264944652771329 -0.6379767435092114 GIS(ph)ISSK ddPTM_A459_Selumetinib_30min_R2 1 GISISSK 7 0 Q8N0X7 Q8N0X7 SPG20 Spartin 1 GIS(1)ISSK 104.2 0.018145 2331700.0 70476.0 126940.0 74849.0 67932.0 63484.0 34563.0 61421.0 54795.0 62985.0 33668.0 True False 66559.22605778114 136675.88982356768 70033.29682942931 58679.544410763665 55508.572365839165 39323.73951832469 64277.19820340261 54954.444378199434 75583.75994794046 32695.917360030562 2.0357044986646287 4.18021272560006 2.1419584609986257 1.7947055519077448 1.697721821186646 1.2027110016615217 1.9659090000630748 1.6807738951952154 2.3117185890718743 1.0 14.996822881567736 -5.480653089676205 8.031840149429081 1.7081519530425995 3.1264796913260016 0.4815210477041171 0.5913296610615215 0.22913001812890282 39.5204905666069 0.1443866170245711 0.2966630445098206 3.3063354252786633e-06 5.480653089676205 1.418327738283402 GIS(ph)PIVFDR ddPTM_A459_Selumetinib_30min_R1 3 GISPIVFDR 9 0 J3QR07;Q96MU7;Q96MU7-2 J3QR07 YTHDC1 YTH domain-containing protein 1 1 GIS(1)PIVFDR;GIS(1)PIVFDR;GIS(1)PIVFDR 144.55 0.0019369 358620000.0 11258.2 12725.3 10578.599999999999 10610.9 11224.5 9048.8 13715.4 12684.3 6978.1 11974.6 True False 11520.494155356202 11235.415960168531 9142.08422409039 8757.905506261754 10209.245956846433 8957.77728765303 12680.836335668113 12347.871159586897 11841.326039740894 13511.656552481436 0.8526337322599016 0.8315350465376602 0.6766072086410035 0.6481740763795059 0.7555880300237123 0.6629666209216901 0.9385108544177182 0.9138680450931971 0.8763785546018942 1.0 13.721916941965898 -7.27286202332582 24.858495921133525 0.925011717392012 0.7361099322118865 0.6531527764886753 0.06926847797059346 486.07637332930597 1057817.922376668 0.030915039361491772 0.021054560047171707 5.3350436452058795e-08 7.27286202332582 -0.18890178518012557 GIS(ph)PIVFDR ddPTM_A459_Selumetinib_30min_R2 4 GISPIVFDR 9 0 J3QR07;Q96MU7;Q96MU7-2 J3QR07 YTHDC1 YTH domain-containing protein 1 1 GIS(1)PIVFDR;GIS(1)PIVFDR;GIS(1)PIVFDR;GIS(1)PIVFDR 143.96 0.001988 405713000.0 240061.0 187557.0 242023.0 265465.0 274875.0 225745.0 284942.0 280662.0 258054.0 193824.0 True False 226719.3706603239 201942.01880919264 226451.5036747184 229308.209047332 240342.74508632137 256839.32464092228 298192.36760186154 281478.6799539044 309672.0106311943 188227.7975047695 1.204494626541965 1.0728597023724704 1.2030715265049008 1.2182483782265028 1.2768716856511662 1.3645132549267291 1.5842100452474648 1.4954150432896185 1.6451980777352906 1.0 17.522120175621765 -6.643442722322355 1.6345641687936516 1.4714154532393686 1.1633521983775033 0.30963676955944397 0.16807481260627996 0.37241212888191194 2.0526023959566966 0.06559362535598208 0.0654977756069787 2.272779364936195e-07 6.643442722322355 -0.30806325486186537 GIS(ph)PVVSEHR ddPTM_A459_Selumetinib_30min_R1 2 GISPVVSEHR 10 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 GIS(1)PVVSEHR;GIS(1)PVVSEHR 118.76 0.0037124 12808600.0 7906.900000000001 8603.2 5640.3 6664.5 11782.2 6084.5 10035.3 7314.9 1339.38 3822.1000000000004 True False 8091.115385850844 7595.93334448083 4874.378239950187 5500.670183158961 10716.502090316362 6023.295454283982 9278.329241533618 7120.885089856134 2272.8300355552583 4312.703765406721 1.8761120229846786 1.7612926270080773 1.13023720271464 1.2754574583307152 2.484868582042689 1.3966402011189236 2.1513949824139154 1.6511417146186902 0.5270081506145167 1.0 12.074376907097516 -8.247101948147437 19.688907233594644 0.7635050811953543 1.7127118950017965 0.4813331474922642 0.39544274198237156 36.070554147225025 49537.64273493371 0.2740638520100707 0.10152900254821891 5.661063832015191e-09 8.247101948147437 0.9492068138064422 GIS(ph)PVVSEHR ddPTM_A459_Selumetinib_30min_R2 1 GISPVVSEHR 10 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 GIS(1)PVVSEHR 101.72 0.010621 23673000.0 79092.0 71703.0 216290.0 328010.0 383160.0 243830.0 120350.0 198930.0 268780.0 238760.0 True False 74696.38327036187 77202.38953851614 202374.13687874613 283334.4721511895 335024.01530613925 277415.36923163774 125946.51346900068 199508.85336536585 322543.5103406755 231866.3784270193 0.3221527147536519 0.33296069081794816 0.8728050105912359 1.221973078086308 1.4449012296605526 1.1964450004076599 0.5431857534646523 0.8604475332682263 1.3910749481180045 1.0 17.822934112906296 -5.353020706217536 3.2097528412523633 1.0828458564363748 0.3114669918649624 0.5987320956462576 0.24706630778405356 0.18492388316779826 3.60878694902511 0.07401151385962465 0.18418550915011409 4.435874941390751e-06 5.353020706217536 -0.7713788645714124 GIS(ph)PVVSEHRK ddPTM_A459_Selumetinib_30min_R2 3 GISPVVSEHRK 11 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 GIS(1)PVVSEHRK;GIS(0.999)PVVS(0.001)EHRK;GIS(1)PVVSEHRK 78.324 0.024538 22091200.0 86241.0 88849.0 130924.0 151617.0 147839.0 88569.0 78056.0 90632.0 79734.0 132086.0 True False 81448.07047007637 95663.43260543677 122500.4923792731 130966.50304608632 129266.1431225709 100768.57580066836 81685.75866502967 90895.72411506464 95683.02795410132 128272.33397935708 0.6349620993345599 0.7457838306803705 0.9550032230565568 1.0210035085754565 1.0077476499599185 0.7855830846337066 0.6368150959050561 0.7086151884450199 0.745936594320484 1.0 16.968850515208935 -6.985541633527969 24.210357549571096 0.7432224078690665 0.8804311465840418 0.09203159789452808 0.1408468326664763 309.4801070746842 518217.52061872947 0.05264331613626959 0.04640529150886837 1.0338519862788813e-07 6.985541633527969 0.1372087387149753 GIS(ph)SLPR ddPTM_A459_Selumetinib_30min_R2 1 GISSLPR 7 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 GIS(0.686)S(0.314)LPR 81.548 0.042821 26114000.0 109070.0 81493.0 92259.0 98247.0 85821.0 65380.0 61727.0 55616.0 46893.0 55152.0 True False 103008.32604180404 87743.25105870464 86323.15638400408 84865.58911447163 75039.39873052559 74385.50153945165 64597.42780973006 55777.833352275564 56272.91029989317 53559.61845789492 1.923246076197919 1.6382351776400847 1.6117208984949307 1.584506976672872 1.4010443108275066 1.3888355384370163 1.2060845403615479 1.0414158083692187 1.0506592824990206 1.0 15.708858062936402 -6.464156126890715 0.43170284695250893 0.9459252191599219 1.924475324502193 0.9488524761605468 0.06614429671947551 0.311069257065519 0.11235198013574221 0.06489728395535573 0.131888939699334 3.434344625779251e-07 6.464156126890715 0.9785501053422712 GISEDSHLESLQDVGQS(ph)AAPTFMISPETVTGTGKK ddPTM_A459_Selumetinib_30min_R1 1 GISEDSHLESLQDVGQSAAPTFMISPETVTGTGKK 35 1 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 GISEDSHLESLQDVGQS(0.433)AAPT(0.433)FMIS(0.129)PET(0.003)VT(0.001)GT(0.002)GKK 98.76 1.2205e-11 79908000.0 1404.2 1481.3 2246.6 2563.8 2138.8 1589.9 1790.3 1618.7 623.7 1142.7 True False 1436.9151279024334 1307.8687073623134 1941.5240596904584 2116.0804584864495 1945.3459176358097 1573.9070495136987 1655.2562296212018 1575.76681772138 1058.373346754331 1289.3766758405739 1.1144261834623896 1.014341838089854 1.505785001442449 1.6411654547007597 1.5087491142707343 1.2206728095865649 1.2837646753165461 1.2221151873203397 0.820841082815736 1.0 10.332458075888002 -8.097256122524595 3.3754252684493076 0.9127753613667304 1.3346701140546924 0.44010308918557794 0.18418974759206896 0.26300580332421125 5.3894041265878165 0.16200848056699402 0.054798982873439095 7.993626966914277e-09 8.097256122524595 0.42189475268796195 GISEDSHLESLQDVGQSAAPTFMIS(ph)PETVTGTGKK ddPTM_A459_Selumetinib_30min_R1 2 GISEDSHLESLQDVGQSAAPTFMISPETVTGTGKK 35 1 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 GISEDSHLESLQDVGQS(0.024)AAPT(0.475)FMIS(0.498)PET(0.002)VT(0.001)GTGKK;GISEDSHLES(0.011)LQDVGQS(0.121)AAPT(0.121)FMIS(0.688)PET(0.039)VT(0.011)GT(0.009)GKK 130.46 1.2745999999999999e-25 135577000.0 4728.3 4994.1 8823.3 9125.3 8437.6 5796.1 6750.8 5350.4 2040.0300000000002 4192.7 True False 4838.460190329779 4409.388450305899 7625.14432291766 7531.737658095951 7674.420569779268 5737.796496437733 6241.581720899742 5208.490011451457 3461.7819121039556 4730.873885356415 1.0227413174775972 0.9320452324790105 1.6117834691218358 1.5920394076470978 1.6221993559232435 1.212840721499271 1.319329551400526 1.100957272941352 0.7317425904798035 1.0 12.207890986962525 -7.945725734709156 2.85456836241011 0.8677084273051855 1.344781848887107 0.38951301488534706 0.2325825303019998 0.3009704851161778 4.802392664652252 0.18415232800948098 0.07044741905362398 1.1331157216308029e-08 7.945725734709156 0.47707342158192156 GISEETTTGVHNLYK ddPTM_A459_Selumetinib_30min_R2 1 GISEETTTGVHNLYK 15 0 P23526-2;P23526 P23526-2 AHCY Adenosylhomocysteinase 0 80.905 0.039756 4920400.0 17165.0 21628.0 24810.0 32241.0 31271.0 21173.0 22409.0 23412.0 24444.0 26546.0 False True 16211.03801693929 23286.798055019044 23213.75161108556 27849.7201811728 27342.457413712993 24089.388560642565 23451.062902591115 23480.125043934757 29333.483022425273 25779.548005208864 0.6288332911680136 0.9033051336010177 0.9004716299290867 1.0803028887684785 1.060625943022288 0.9344379721388134 0.9096770392503674 0.9108043724890172 1.1378587016536643 1.0 14.653939348588027 -4.394248886080151 1.3306278597626608 0.9926592633140341 0.09047041143901778 0.6800403181530874 0.07548411899270871 2.0069791520832663 1.5897811439257477 0.02278988258141871 3.148079396904794 4.034141375799834e-05 4.394248886080151 -0.9021888518750163 GISHVIVDEIHER ddPTM_A459_Selumetinib_30min_R1 4 GISHVIVDEIHER 13 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ;;; 228.93 2.9766e-13 24082100.0 12309.1 17092.0 14852.8 16149.0 14902.400000000001 13290.199999999999 14342.0 13386.0 7267.9 10962.099999999999 False True 12595.878080660763 15090.86069414478 12835.871340590415 13328.880304274002 13554.480551232411 13156.512654536109 13260.171393189557 13030.959796144069 12333.095473586338 12369.192314896256 1.018326642515818 1.220036062982933 1.037729143004118 1.0775869567669338 1.0958258394049472 1.0636517178806963 1.0720321145965443 1.053501268668193 0.9970817139558541 1.0 13.594463677653785 -7.901691609426662 0.7260244431906686 0.9926463347222777 1.0963987069537562 0.2956504824799807 0.05109685638463278 0.7900242000017416 0.8293833555770442 0.045941262016596596 0.020969561882259225 1.2540313409109954e-08 7.901691609426662 0.10375237223147848 GISHVIVDEIHER ddPTM_A459_Selumetinib_30min_R2 2 GISHVIVDEIHER 13 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ; 184.98 7.0368e-05 9193000.0 41357.0 37232.0 48129.0 46096.0 49834.0 37027.0 33447.0 40830.0 32484.0 44851.0 False True 39058.54350518833 40087.57468025105 45032.43253889307 39817.64527996467 43573.40739838746 42127.13315235968 35002.35177397315 40948.80854022964 38981.70767879488 43556.03509310712 0.8967424014076403 0.9203678570503088 1.0338965069393928 0.9141705666011353 1.0003988495565128 0.9671939390788679 0.8036165757317147 0.9401408657306808 0.8949783329787945 1.0 15.410585011018025 GISQDRS(ph)PLVK ddPTM_A459_Selumetinib_30min_R2 1 GISQDRSPLVK 11 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 GIS(0.002)QDRS(0.998)PLVK 66.78399999999999 0.042165 30225000.0 366800.0 268840.0 286990.0 305840.0 340740.0 238280.0 279520.0 273440.0 220940.0 246830.0 True False 346414.7244167393 289459.1635431529 268525.37585108634 264184.0643965723 297933.1949457505 271100.9071095218 292518.23385837267 274235.66512957116 265134.1735793908 239703.37655864193 1.4451808288649246 1.2075723241734917 1.1202402723993055 1.1021290905009062 1.2429244811779405 1.1309849323011045 1.220334223313746 1.1440625871303949 1.1060927776064404 1.0 17.870890705952426 -4.770303524518834 2.970345486365365 1.1447054572511304 1.4999979732501951 0.6815414559994964 0.06364862026171177 0.23066793389892373 2.858375255018255 0.015541488729996554 0.20109904163604006 1.697057179857992e-05 4.770303524518834 0.35529251599906475 GISQEQMQEFR ddPTM_A459_Selumetinib_30min_R1 3 GISQEQMQEFR 11 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ;; 219.03 0.0021529 266150000.0 4574.700000000001 5101.6 5326.0 5146.7 5399.3 4028.3 4962.3 4124.8 2619.04 4060.6000000000004 False True 4681.281609183353 4504.302300330506 4602.758453623866 4247.925460524306 4910.934268323841 3987.7789594037586 4587.9897158293525 4015.39690476132 4444.319592886742 4581.817563593452 1.0217084255777074 0.983081983909863 1.0045704329645964 0.9271267137037033 1.0718310365182386 0.870348699845701 1.0013470968999165 0.8763764268283313 0.9699905182172132 1.0 12.161704299974488 -6.76512033906095 24.999987125679077 0.9394945007268063 0.9966519338663772 0.22348287108840048 0.05342475553450665 144.04050135085112 978273.9905106823 0.01710905456767596 0.015673426839498072 1.7174324362725152e-07 6.76512033906095 0.05715743313957089 GISQEQMQEFR ddPTM_A459_Selumetinib_30min_R2 8 GISQEQMQEFR 11 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ;;;;;;; 242.35 1.6142e-08 158025000.0 225212.0 213318.0 242860.0 264398.0 270971.0 187947.0 188692.0 180488.2 179161.8 222408.7 False True 212695.61863506734 229678.80467452187 227234.65200597505 228386.53628800993 236929.20046852424 213834.99323700398 197466.5518861049 181013.39078057022 214999.16619895058 215987.18294379898 0.984760372056021 1.063390899145555 1.0520747060491211 1.0574078201086465 1.096959538243408 0.9900355674931183 0.9142512495173695 0.8380746871802613 0.9954255769653448 1.0 17.720586177325295 -7.027929751640926 4.053658123811406 0.9249810472599139 1.0519781664337198 0.5287859619859243 0.05013733762835368 0.15508093594924818 5.67815941844194 0.019010062476900774 0.015264978560341784 9.377136724943978e-08 7.027929751640926 0.12699711917380585 GISS(ph)DNESVASCNSVK ddPTM_A459_Selumetinib_30min_R1 2 GISSDNESVASCNSVK 16 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;E9PNV5 A0A0A0MTL4 NAV2 Neuron navigator 2 1 GIS(0.117)S(0.883)DNESVASCNSVK;GIS(0.003)S(0.997)DNESVASCNSVK 252.82 1.2114e-29 9405100.0 1756.4 1957.63 1864.42 2312.2 2154.4 1815.31 1932.8600000000001 1889.56 964.83 1598.22 True False 1797.320702640533 1728.4297695225034 1611.242004525987 1908.4176753695192 1959.5349003902124 1797.0496295696043 1787.0628140454867 1839.4427306441046 1637.2460416049064 1803.367104981116 0.9966471594586138 0.9584458786834767 0.8934631224422047 1.0582524601331813 1.0865978951139468 0.9964968444893655 0.9909589728621561 1.0200045933871942 0.9078828359919823 1.0 10.816477395589638 -5.767265164757578 24.99989080607213 1.01144329045812 0.9504114366909401 0.22631519416285706 0.049856542108317844 209.6417831533087 899628.8981156572 0.014619764673290188 0.02234171364762102 1.7089715592571915e-06 5.767265164757578 -0.06103185376718001 GISS(ph)DNESVASCNSVK ddPTM_A459_Selumetinib_30min_R2 2 GISSDNESVASCNSVK 16 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;E9PNV5 A0A0A0MTL4 NAV2 Neuron navigator 2 1 GIS(0.046)S(0.954)DNESVASCNSVK;GIS(0.051)S(0.949)DNESVASCNSVK 207.05 7.444e-08 12874400.0 76749.0 68667.0 75611.0 85735.0 90737.0 68807.0 68797.0 77279.0 53408.0 71757.0 True False 72483.59783058979 73933.53810079502 70746.27057903224 74057.74509887579 79337.80686092793 78284.53968224306 71996.19681866937 77503.86909577281 64091.0923442026 69685.1889629237 1.0401578715551019 1.060964879353799 1.015226788244387 1.0627472810366996 1.1385174962091291 1.123402847108511 1.0331635443648615 1.1122000277133361 0.9197233055980165 1.0 16.08856443477716 -8.26111911775651 24.999998896110224 0.9598616477210884 1.0731055021015612 0.5356907991362703 0.04224293101155797 23.03727592386693 1798700.34922806 0.03451299925904859 0.011136753396482237 5.481266048102854e-09 8.26111911775651 0.1132438543804728 GISS(ph)LPR ddPTM_A459_Selumetinib_30min_R2 1 GISSLPR 7 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 GIS(0.116)S(0.884)LPR 80.219 0.0453 9913700.0 65867.0 43571.0 56169.0 55479.0 47643.0 36323.0 37557.0 39581.0 31449.0 39928.0 True False 62206.37582649226 46912.75559715347 52555.147692183185 47922.664493386845 41657.66040617596 41326.1635426354 39303.47491778366 39696.17415701273 37739.67875847866 38775.17489459728 1.6042835653375673 1.209865738186265 1.355381318976486 1.2359109823142056 1.0743384270841885 1.0657892235166568 1.013624697364292 1.0237522916381165 0.9732948687160428 1.0 15.242845668070625 -1.522878745280339 0.30035188627383974 0.9595282254012876 5.994572363629769 0.8563014587116891 0.07195264889909127 19.00764561460776 0.2708986319282601 0.07243593094765102 51.44065516635195 0.029999999999999905 1.522878745280339 5.035044138228481 GITVTAYS(ph)PLGSPDRPWAKPEDPSLLEDPK ddPTM_A459_Selumetinib_30min_R1 1 GITVTAYSPLGSPDRPWAKPEDPSLLEDPK 30 2 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 1 GIT(0.015)VT(0.037)AY(0.289)S(0.322)PLGS(0.322)PDRPWAKPEDPS(0.015)LLEDPK 44.161 0.016891 57176000.0 2716.5 2984.7 3041.0 3072.4 2311.9 3358.7 2565.6 2440.9 1365.8 2312.2 True False 2779.7891646111393 2635.249936450615 2628.0489030173085 2535.8630160908706 2102.7890531990965 3324.9145274556026 2372.0747264235893 2376.159402839388 2317.6628459148046 2608.993392735256 1.0654642408644899 1.010063859796836 1.0073037786661756 0.9719698881384611 0.8059771477590991 1.2744051160550387 0.9091915422356505 0.9107571561721105 0.8883360350272785 1.0 11.349277575202983 GITVTAYSPLGSPDRPWAKPEDPSLLEDPK ddPTM_A459_Selumetinib_30min_R1 2 GITVTAYSPLGSPDRPWAKPEDPSLLEDPK 30 2 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 0 ; 62.717 0.00081599 40527000.0 4105.8 5002.8 6601.6 6858.9 4090.0 4469.8 3800.2 4554.4 4768.6 4313.2 False True 4201.457151503924 4417.069850261379 5705.138979993115 5661.121872498911 3720.060222148148 4424.837870253682 3513.547854441426 4433.602517223854 8091.965915236007 4866.841234125813 0.8632821473697805 0.9075845374386406 1.172246782983024 1.1632024962728762 0.7643685181393326 0.9091806486776585 0.7219359920362254 0.910981538936563 1.6626730821823275 1.0 12.248769996513893 -8.225111112233838 24.910097541465216 1.3313366677161211 0.9292288389871383 0.39046261186818054 0.202254995576569 484.77990814763604 332411.91744952265 0.13569537967419468 0.051284326057621135 5.9550976561897014e-09 8.225111112233838 -0.4021078287289829 GIVEFAS(ph)KPAAR ddPTM_A459_Selumetinib_30min_R2 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 GIVEFAS(1)KPAAR 76.311 0.026395 7627600.0 40317.0 43100.0 41439.0 39923.0 43816.0 24160.0 26720.0 34274.0 25313.0 40548.0 True False 38076.3425417385 46405.63141165715 38772.85985537179 34485.41852898366 38311.44235999006 27487.82069735627 27962.532944675564 34373.73166563385 30376.307304313974 39377.273883643815 0.9669623817598586 1.1784876614054463 0.9846506888704888 0.8757695779267216 0.9729328260050916 0.6980630700484809 0.710118557909881 0.8729332499554193 0.7714172239061835 1.0 15.26507561545409 -5.911819393854792 1.3010650883353039 0.8086530948127909 1.0764664974409839 0.44120457177159456 0.10548143682573523 0.37995206402193155 1.3029217389347452 0.037209397598233884 0.07674654388695573 1.225125575311397e-06 5.911819393854792 0.267813402628193 GIVEFSGKPAAR ddPTM_A459_Selumetinib_30min_R1 1 GIVEFSGKPAAR 12 1 Q15233-2;Q15233;H7C367;C9IZL7 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 0 105.13 0.026631 7197000.0 1782.2 1640.7 2676.3 2127.5 2184.3 1704.3 1862.0 1888.3 1328.5 1475.6 False True 1823.7217924424704 1448.6060812592636 2312.873159863604 1755.9720631211185 1986.730450669487 1687.1562893805883 1721.5478408952006 1838.2161499371618 2254.3674701990185 1665.0076335611716 1.095323382116775 0.8700296935942201 1.389106640260115 1.0546330405497237 1.193226031294646 1.0133024349996789 1.0339579267952659 1.1040286620221231 1.353968249008748 1.0 10.701313076298325 -8.036886036648246 24.87012887384087 1.1943222577095343 1.093107871581316 0.045051180003646385 0.14899785824768902 1559.6886119448782 1051599.2676146945 0.09626642424004962 0.03641028101212658 9.185736080499808e-09 8.036886036648246 -0.1012143861282182 GIVEFSGKPAAR ddPTM_A459_Selumetinib_30min_R2 2 GIVEFSGKPAAR 12 1 Q15233-2;Q15233;H7C367;C9IZL7 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 0 ; 127.51 0.0072764 10454100.0 62656.0 61813.0 70349.0 78178.0 69795.0 43676.0 43162.0 44726.0 41710.0 59837.0 False True 59173.830351840836 66553.85833987861 65822.82193019998 67530.02153542764 61026.72812478324 49691.97254874719 45169.11852388048 44856.14525521211 50053.16547477328 58109.35033480306 1.0183185668210823 1.1453209845992365 1.1327406269551277 1.1621197130297691 1.0502049631112964 0.8551458975610935 0.7773123991859127 0.7719264627253406 0.8613616429436359 1.0 15.826482704905333 -6.705981876293288 3.3522015601571447 0.8307392827421748 1.1171708977076569 0.7603987903857595 0.07001609921868583 0.10439476921225976 2.384984833116278 0.024103306520945257 0.023212274587562497 1.9679684140248744e-07 6.705981876293288 0.2864316149654821 GIVVTAYSPLGS(ph)PDRPWAKPEDPSLLEDPR ddPTM_A459_Selumetinib_30min_R1 1 GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 30 2 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 1 GIVVT(0.016)AY(0.087)S(0.087)PLGS(0.628)PDRPWAKPEDPS(0.182)LLEDPR 40.997 0.028352 15865000.0 1725.8 1747.5 1957.5 1993.3 1483.2 1858.4 1935.2 1023.5 991.18 1013.5 True False 1766.007782177766 1542.901887609291 1691.6822517778292 1645.207573875124 1349.044821880229 1839.7061832921943 1789.2263059615418 996.3534552034554 1681.9600670770517 1143.592597326001 1.5442630411451805 1.3491709295923853 1.4792700265229033 1.4386308355982904 1.17965508436713 1.6087076705409575 1.564566183923532 0.8712486050829407 1.470768585779486 1.0 10.159357470957767 -8.343757122665039 0.6590121226812755 1.019359907649677 1.4428082480227844 0.2744391012676626 0.20346662602828275 0.9479168247570232 0.9581343415771376 0.19708239112349143 0.0847241177194419 4.53150931778094e-09 8.343757122665039 0.4234483403731073 GKAESS(ph)EDETSSPAPSK ddPTM_A459_Selumetinib_30min_R1 1 GKAESSEDETSSPAPSK 17 1 I3L1U0;A0A0J9YWQ1;Q96NA2-2;Q96NA2 I3L1U0 RILP Rab-interacting lysosomal protein 1 GKAES(0.404)S(0.558)EDET(0.024)S(0.005)S(0.007)PAPS(0.001)K 63.706 0.026298 5950800.0 2618.9 2720.3 2743.6 3381.5 3615.3 2698.5 3259.9 2730.3 1608.2 2127.7 True False 2679.9152745076794 2401.8060113668416 2371.0341895160423 2790.9845036164816 3288.296753333059 2671.3555400419636 3014.0031184394516 2657.8835747357048 2728.9979417192776 2400.8110205530666 1.1162541539359965 1.000414439456191 0.9875971782942896 1.1625173658914363 1.3696608042791911 1.1126888027307424 1.255410397835114 1.107077380094422 1.1366983566622448 1.0 11.229306131195417 -5.819908539839478 7.307029244138428 1.1788647199391609 1.0315968744100121 0.25712012167964815 0.09788797980055412 0.25655852538536644 26.60845816433839 0.027106512704785764 0.04063939908850925 1.5138800301336781e-06 5.819908539839478 -0.14726784552914873 GKAS(ph)PFEEDQNR ddPTM_A459_Selumetinib_30min_R1 2 GKASPFEEDQNR 12 1 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 GKAS(1)PFEEDQNR;GKAS(1)PFEEDQNR 145.61 0.0032206 287501000.0 13083.2 15246.3 17930.0 18496.2 17668.2 14902.2 15888.9 15360.4 9381.8 13427.0 True False 13388.013104524374 13461.256108187428 15495.204482440095 15266.185886674893 16070.11442957407 14752.297398115 14690.387480773219 14952.992294389007 15920.22938043895 15150.486240055474 0.8836688732226031 0.8885032397572832 1.0227529491082101 1.007636695270778 1.0606995825049659 0.9737177516528991 0.9696314196130664 0.986964514370217 1.0508064974408806 1.0 13.887076475878677 -5.25633496845128 24.633174050763316 1.007688508086194 0.886086034598485 0.7513350686678557 0.02828234907714769 167.49592776922523 808303.4836489172 0.007626245272365925 0.018879687277359378 5.541980987560086e-06 5.25633496845128 -0.12160247348770892 GKAS(ph)PFEEDQNR ddPTM_A459_Selumetinib_30min_R2 6 GKASPFEEDQNR 12 1 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 GKAS(1)PFEEDQNR;GKAS(1)PFEEDQNR;GKAS(1)PFEEDQNR;GKAS(1)PFEEDQNR;GKAS(1)PFEEDQNR;GKAS(1)PFEEDQNR 211.82 2.1347e-05 246869900.0 257045.0 255522.0 288537.0 312442.0 319319.0 226739.0 239950.0 244370.0 218547.0 273996.0 True False 242759.46793266296 275119.71576727304 269972.84355533286 269886.86060748645 279203.2924719202 257970.23911828888 251108.1504519046 245081.07624236876 262262.5067133845 266085.0235528975 0.9123379613449103 1.0339541553062246 1.014611194386378 1.0142880535094572 1.0493010419897413 0.9695030395688715 0.9437139569111619 0.9210630232770196 0.9856342277800046 1.0 18.021527785796543 -6.981025663308305 24.01648455449971 0.9561081119822362 1.0077567602049604 0.20270982850664265 0.039732457470010536 200.11119599675618 253286.23333456911 0.013723712920185838 0.012101154824985812 1.0446584864886227e-07 6.981025663308305 0.05164864822272419 GKDSYETSQLDDQS(ph)AETHSHK ddPTM_A459_Selumetinib_30min_R1 2 GKDSYETSQLDDQSAETHSHK 21 1 P10451-3;P10451-4;P10451-5;P10451-2;P10451;D6R9C5 P10451-3 SPP1 Osteopontin 1 GKDSYETSQLDDQS(0.613)AET(0.128)HS(0.259)HK;GKDSYETSQLDDQS(0.714)AET(0.222)HS(0.064)HK 70.094 0.0027587 16966800.0 3036.2 4038.6 3937.1 3785.6 3605.8 3718.0 3431.3999999999996 3670.1000000000004 1390.5500000000002 2976.6 True False 3106.9375525832293 3565.758834505796 3402.4634449422706 3124.516024512951 3279.6560266556944 3680.6002956739 3172.5667353640106 3572.7570258350793 2359.661788246326 3358.675604539297 0.9250484174131492 1.0616562164225158 1.0130372341835554 0.9302821684506011 0.9764729949576534 1.0958487002137143 0.9445886143562785 1.0637398327502805 0.7025572178084749 1.0 11.713676745217342 -8.23860262245595 24.997985515300996 0.8512785092440155 1.0017969495586083 0.32288543580114937 0.08691780823233675 735.8773350986437 805522.1031149436 0.054080502493777285 0.02040974281635142 5.772944436867894e-09 8.23860262245595 0.15051844031459283 GKDSYETSQLDDQS(ph)AETHSHK ddPTM_A459_Selumetinib_30min_R2 1 GKDSYETSQLDDQSAETHSHK 21 1 P10451-3;P10451-4;P10451-5;P10451-2;P10451;D6R9C5 P10451-3 SPP1 Osteopontin 1 GKDS(0.002)Y(0.002)ET(0.01)S(0.008)QLDDQS(0.439)AET(0.439)HS(0.099)HK 45.347 0.041256 6200700.0 21674.0 14360.0 19155.0 17310.0 16064.0 17905.0 19305.0 15188.0 15194.0 22016.0 True False 20469.44584789643 15461.365825322426 17922.588154387107 14952.348138584453 14045.896706017897 20371.251224592866 20202.720752131798 15232.194565491245 18233.224555830864 21380.34087556235 0.9573956732978439 0.7231580597947673 0.8382742005237418 0.6993503155824299 0.6569538244393617 0.9528029203630299 0.9449204233793781 0.7124392756011475 0.8528032673544215 1.0 14.38399723427123 -6.77501281627377 24.999464855335887 0.8778910646794065 0.7714543549006684 0.228664631906059 0.10616026419418882 413.40685913479354 761405.3545454405 0.038066656670866714 0.03375098876975678 1.6787544764052996e-07 6.77501281627377 -0.10643670977873809 GKGFSVVADT(ph)PELQR ddPTM_A459_Selumetinib_30min_R2 1 GKGFSVVADTPELQR 15 1 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 GKGFSVVADT(1)PELQR 96.012 0.014463 9282500.0 60980.0 83565.0 87711.0 105330.0 95741.0 46198.0 37946.0 32248.0 25093.0 73269.0 True False 57590.975722281284 89974.16679617461 82067.76975251624 90983.87229561519 83713.15964460032 52561.3551563106 39710.564188572534 32341.83634105621 30112.301157000384 71153.53359427593 0.809390241258718 1.2645073582601771 1.1533899387270674 1.2786978762630918 1.1765144387900754 0.7387033714449144 0.558096867191528 0.45453591279770267 0.42320176716315355 1.0 16.11864778454227 -6.881292804186774 3.3941646943130643 0.5701799724570507 1.154095232035298 0.6308504493880119 0.19230547808245096 0.14176365617460063 3.200336578661025 0.06983418553940732 0.06105686064281076 1.3143383978417464e-07 6.881292804186774 0.5839152595782473 GKGGVT(ph)GSPEASISGSK ddPTM_A459_Selumetinib_30min_R2 1 GKGGVTGSPEASISGSK 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GKGGVT(0.628)GS(0.372)PEASISGSK 117.53 0.016371 60520000.0 67918.0 63471.0 70216.0 79342.0 58068.0 55854.0 60716.0 68097.0 54399.0 60551.0 True False 64143.38945729586 68339.02160856834 65698.37900540052 68535.48272741567 50772.97870549347 63547.381507869875 63539.41430647159 68295.15099593479 65280.32003505612 58802.73529960831 1.0908232266828433 1.1621741958154037 1.1172673970123657 1.1655152158860915 0.8634458660264342 1.0806875085671936 1.0805520182476076 1.1614281316670265 1.1101578813033712 1.0 15.843595645349133 GKGGVTGS(ph)PEASISGSK ddPTM_A459_Selumetinib_30min_R1 4 GKGGVTGSPEASISGSK 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GKGGVTGS(0.617)PEAS(0.303)IS(0.059)GS(0.021)K;GKGGVT(0.026)GS(0.967)PEAS(0.003)IS(0.003)GSK;GKGGVTGS(0.991)PEAS(0.004)IS(0.002)GS(0.002)K;GKGGVT(0.062)GS(0.936)PEAS(0.001)IS(0.001)GSK 206.45 2.8084e-08 1673040000.0 26340.200000000004 28965.7 35820.0 35115.0 32638.899999999998 26609.100000000002 27779.899999999998 26540.1 15418.300000000001 21002.0 True False 26953.87541089283 25574.382378211405 30955.840745175916 28982.824440187123 29686.717257865836 26341.436613129736 25684.439777274205 25836.1703336055 26163.728991922864 23697.811276803845 1.137399361318913 1.079187528311714 1.3062742539213508 1.2230169318867188 1.252719793870758 1.111555675140073 1.083831729321557 1.0902344537993156 1.1040567707420617 1.0 14.532466197917001 -6.922504919301959 5.574515180222748 1.079661955218886 1.1998720279047141 0.4855767048293739 0.06345317990233149 0.20446048843893425 10.906122886581661 0.0240785408438198 0.02113543258397708 1.1953499857346334e-07 6.922504919301959 0.12021007268582817 GKGGVTGS(ph)PEASISGSK ddPTM_A459_Selumetinib_30min_R2 1 GKGGVTGSPEASISGSK 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GKGGVT(0.062)GS(0.937)PEASIS(0.001)GSK 202.61 1.6129e-07 49192000.0 65296.0 60880.0 64014.0 71686.0 53577.0 44321.0 71549.0 54972.0 43663.0 55959.0 True False 61667.10972059818 65549.30023994634 59895.40893317333 61922.243134752425 46846.178275542894 50425.815444020125 74876.17027165383 55131.95941889549 52396.82004615263 54343.31827105709 1.1347689409213293 1.2062071718365694 1.1021669422986495 1.139463785150047 0.862041181252137 0.9279119687263668 1.377835815954073 1.0145122008174907 0.9641814617356343 1.0 15.729815040564574 -6.0435393509051885 24.894685734116123 1.034600569526842 1.1481058608815213 0.16855291705262898 0.1308408373317492 924.6757921847528 528704.235335804 0.04099216053473008 0.052923907153841876 9.04608468529856e-07 6.0435393509051885 0.11350529135467924 GKGGVTGSPEASISGS(ph)KGDLK ddPTM_A459_Selumetinib_30min_R1 2 GKGGVTGSPEASISGSKGDLK 21 2 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GKGGVTGSPEASIS(0.026)GS(0.974)KGDLK;GKGGVTGSPEASIS(0.057)GS(0.943)KGDLK 140.13 2.3184e-05 60356000.0 9784.900000000001 9325.2 12891.9 12057.400000000001 7768.7 9543.5 8120.8 7068.6 5232.2 8508.9 True False 10012.869131898971 8233.401248832139 11141.250790137732 9951.801435429645 7066.022456675385 9447.5010548047 7508.241517906412 6881.117765951291 8878.661255231698 9601.100198704706 1.0428876821064545 0.8575476849979042 1.1604139691866573 1.0365271926619672 0.7359596619592272 0.9840019226212504 0.782018868933308 0.7167009637999227 0.9247545668182411 1.0 13.228984019690623 -6.239993044397632 24.470143940570924 0.8456514838330679 1.0221494020552957 0.33949919331328016 0.11348077921638502 687.569768289638 784512.651226385 0.03290503045800939 0.04243596709254458 5.754491535800739e-07 6.239993044397632 0.17649791822222782 GKGS(ph)PRPQAPK ddPTM_A459_Selumetinib_30min_R1 1 GKGSPRPQAPK 11 2 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 GKGS(1)PRPQAPK 106.58 0.012479 866750000.0 12179.0 13882.0 13961.0 14970.0 13861.0 13954.0 13776.0 13191.0 8910.6 11513.0 True False 12462.7470037913 12256.688986433284 12065.172882283672 12355.77052170301 12607.274997358314 13813.635429218284 12736.865228878767 12841.131829593332 15120.637395525304 12990.80569611668 0.9593513516653374 0.9434895165968925 0.9287470819373654 0.9511165674194095 0.9704767581218604 1.0633393919014253 0.9804522927077708 0.9884784770071583 1.1639491613707447 1.0 13.665203289761399 -6.606148330263349 4.640474829134464 1.0345947149577066 0.9459129749309926 0.4496769435835445 0.04939433865174427 0.21043519910535533 8.225878639269101 0.016519377766041142 0.016563658255757775 2.4765760558208324e-07 6.606148330263349 -0.08868174002671403 GKIEVLDS(ph)PASK ddPTM_A459_Selumetinib_30min_R1 2 GKIEVLDSPASK 12 1 Q8N5I9 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 GKIEVLDS(0.708)PAS(0.292)K;GKIEVLDS(0.935)PAS(0.065)K 120.92 0.012015 167736000.0 9602.7 12254.599999999999 12353.599999999999 13642.7 10846.2 10920.0 10520.0 9259.3 6489.8 8536.9 True False 9826.42422639845 10819.825734991024 10676.048973467481 11260.258550196235 9865.16312505214 10810.154714566694 9726.467930299403 9013.713285554817 11012.716603761823 9632.694271447795 1.0201117101292094 1.1232398153714893 1.1083139018656791 1.1689625179502159 1.0241333158775114 1.1222358366141651 1.0097349356482288 0.9357416556105496 1.1432644173504543 1.0 13.233723662004532 -7.269808407804492 24.536426161050642 1.0168303833657075 1.0966200385853289 0.23348390343011804 0.06382583117864175 662.2477884710438 1941575.0462930948 0.025464374606070282 0.01750045244468262 5.372687641516368e-08 7.269808407804492 0.07978965521962134 GKIEVLDS(ph)PASK ddPTM_A459_Selumetinib_30min_R2 1 GKIEVLDSPASK 12 1 Q8N5I9 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 GKIEVLDS(0.882)PAS(0.118)K 95.873 0.009699700000000002 83376000.0 88329.0 94693.0 81582.0 87617.0 90934.0 73346.0 80473.0 75355.0 55518.0 89748.0 True False 83420.0277890026 101955.64861401531 76333.10293976536 75683.41345224467 79510.05795972548 83448.74573130348 84215.15395422431 75574.27057430822 66623.1513025286 87156.74204669204 0.9571265036996497 1.169796463472615 0.875814092487209 0.8683598270768218 0.9122651454448579 0.9574560013567041 0.9662494487128506 0.8671075673505693 0.7644061691387788 1.0 16.411324648502948 -5.280666977056861 24.926499943817213 0.9002290194871159 1.0634614939534497 0.405670931264163 0.07842424336444051 647.0751734890529 838862.0853837812 0.020266043971328584 0.04229358125531089 5.240020945339806e-06 5.280666977056861 0.16323247446633382 GKLS(ph)AEENPDDSEVPSSSGINSTK ddPTM_A459_Selumetinib_30min_R1 4 GKLSAEENPDDSEVPSSSGINSTK 24 1 A0A494C1S7;Q9Y5Q9-2;Q9Y5Q9 A0A494C1S7 GTF3C3 General transcription factor 3C polypeptide 3 1 GKLS(0.744)AEENPDDS(0.256)EVPSSSGINSTK;GKLS(1)AEENPDDSEVPSSSGINSTK;GKLS(1)AEENPDDSEVPSSSGINSTK;GKLS(0.999)AEENPDDS(0.001)EVPSSSGINSTK 150.92 5.1592e-10 477533000.0 15292.300000000001 18462.1 20088.600000000002 20757.5 15826.599999999999 16631.1 15425.6 15498.5 7973.000000000001 12363.7 True False 15648.580836364039 16300.548749202562 17360.678458781163 17132.592291533074 14395.086824413167 16463.8062338306 14262.034572778184 15087.429433776986 13529.598675119898 13950.701327636392 1.1217056740627183 1.1684393756542628 1.244430516506693 1.2280810755795728 1.031853989727129 1.1801418328135043 1.022316673393691 1.0814817892982005 0.9698149474620112 1.0 13.768050030383128 -7.237532907877134 0.7852865177179027 0.9938939711754216 1.1859802414249658 0.5855027149698552 0.0599057061268736 0.47700136342456734 0.5796615536065358 0.04895509648613549 0.03053875753550516 5.787181353700182e-08 7.237532907877134 0.19208627024954428 GKLS(ph)AEENPDDSEVPSSSGINSTK ddPTM_A459_Selumetinib_30min_R2 4 GKLSAEENPDDSEVPSSSGINSTK 24 1 A0A494C1S7;Q9Y5Q9-2;Q9Y5Q9 A0A494C1S7 GTF3C3 General transcription factor 3C polypeptide 3 1 GKLS(1)AEENPDDSEVPSSSGINSTK;GKLS(0.997)AEENPDDS(0.003)EVPSSSGINSTK;GKLS(1)AEENPDDSEVPSSSGINSTK;GKLS(1)AEENPDDSEVPSSSGINSTK 109.46 2.3039e-07 281426500.0 310091.0 246738.0 297901.0 333703.0 338193.0 245908.0 268572.0 300922.0 223581.0 292072.0 True False 292857.38361262565 265662.0112122851 278734.3739900845 288252.0757302158 295706.17185621976 279779.59486943186 281061.13016532164 301797.6331996808 268303.4473750966 283639.1224658091 1.0324999635687695 0.9366197755188336 0.9827077857487172 1.0162634590895083 1.0425436705822035 0.9863928235187567 0.99091101298694 1.0640197677105017 0.9459324406400915 1.0 18.11369701228473 -5.706006992371985 6.862840183949679 1.0092317377849633 0.9788324434684098 0.06475889540453605 0.03712364990923895 0.45510731780268054 44.116687119288756 0.00964133973025186 0.016675842215329882 1.967854605946718e-06 5.706006992371985 -0.030399294316553527 GKNEESLES(ph)TEGFR ddPTM_A459_Selumetinib_30min_R2 1 GKNEESLESTEGFR 14 1 A0A087WWW8;Q9Y6J0-2;Q9Y6J0 A0A087WWW8 CABIN1 Calcineurin-binding protein cabin-1 1 GKNEES(0.277)LES(0.688)T(0.035)EGFR 65.905 0.038875 5766700.0 19333.0 18509.0 20075.0 20461.0 20058.0 15014.0 16186.0 19472.0 15019.0 18554.0 True False 18258.549256130926 19928.580784184753 18783.39635600736 17674.176502806262 17538.13471920486 17082.042216477927 16938.68107195053 19528.660296236878 18023.219665922315 18018.29781091859 1.0133337481560967 1.1060190586986849 1.0424623098761938 0.980901563969944 0.9733513622234191 0.9480386213911217 0.9400822014211664 1.0838238162765326 1.0002731587109601 1.0 14.1371751056987 -5.65486490432092 4.541846117661665 0.9886080651193887 1.0627266865542007 0.3288723336697408 0.0424362467813874 0.24169567693537494 8.49354217738317 0.012326412709445515 0.021905752935102444 2.213783242505826e-06 5.65486490432092 0.07411862143481196 GKPLPS(ph)SPDLTR ddPTM_A459_Selumetinib_30min_R2 1 GKPLPSSPDLTR 12 1 Q86TB3 Q86TB3 ALPK2 Alpha-protein kinase 2 1 GKPLPS(0.698)S(0.302)PDLTR 98.182 0.0085342 5698000.0 31088.0 33975.0 36705.0 34661.0 39794.0 29524.0 33974.0 35617.0 31538.0 37149.0 True False 29360.2534151243 36580.773253156665 34343.440261382326 29940.112006439966 34794.721957126254 33590.66300781235 35553.858318203864 35720.63957328823 37846.48124534642 36076.411845306415 0.8138351879621339 1.0139803650654873 0.9519638596167775 0.829908255145258 0.9644729111732072 0.9310976699081712 0.9855153686197167 0.9901383687062972 1.049064452629878 1.0 15.138768235038352 -7.385472618193419 1.2564625131584752 1.021147417011184 0.9164510926998142 0.3827360687185044 0.05704753135528502 0.5321172663022078 1.6079617500786318 0.03919708123969093 0.020282397072849925 4.116493005365021e-08 7.385472618193419 -0.10469632431136988 GKPLPSS(ph)PDLTR ddPTM_A459_Selumetinib_30min_R2 1 GKPLPSSPDLTR 12 1 Q86TB3 Q86TB3 ALPK2 Alpha-protein kinase 2 1 GKPLPS(0.027)S(0.973)PDLTR 97.203 0.0090284 5549100.0 26014.0 25165.0 28773.0 24401.0 33232.0 24564.0 33804.0 27684.0 34997.0 29769.0 True False 24568.246022292973 27095.07458177152 26921.776505673715 21077.54170592716 29057.099062150555 27947.468030209395 35375.952981355236 27764.555856667084 41997.37789788158 28909.491620849167 0.849833208570664 0.93723801639704 0.9312435119494825 0.7290872486573337 1.005105847008217 0.9667229156687773 1.2236795252339387 0.9603958527116966 1.4527193507475447 1.0 14.819255618508702 -6.973692777081699 1.6069978849758515 1.1624336326430278 0.8761265312172288 0.44706011813790214 0.1414766131660279 0.3465267640324582 1.8180477222542206 0.06413924620171085 0.04915471073152497 1.062446873686133e-07 6.973692777081699 -0.28630710142579896 GKPPS(ph)PTPWSGSNMK ddPTM_A459_Selumetinib_30min_R2 1 GKPPSPTPWSGSNMK 15 1 Q9Y6R9-2;Q9Y6R9 Q9Y6R9-2 CCDC61 Coiled-coil domain-containing protein 61 1 GKPPS(0.944)PT(0.055)PWSGSNMK 84.208 0.012111 16069000.0 88833.0 84528.0 77514.0 98692.0 94887.0 69386.0 91954.0 85685.0 72250.0 93305.0 True False 83896.01748667451 91011.0257996419 72526.833630862 85249.97934680406 82966.4467594571 78943.29167660426 96230.04320339435 85934.3291640847 86702.01883366979 90611.04221449589 0.9258917614927609 1.0044142918497634 0.8004193733824995 0.9408343317031821 0.91563284928406 0.8712325754926034 1.0620123204807321 0.9483869411926595 0.9568593045031687 1.0 16.467399252970793 -7.244293701844201 24.915933504268576 0.987513562889136 0.9107534738814537 0.33565116630026126 0.05642894326747087 994.610644210779 1445360.0908861314 0.021479683890939887 0.016594719325333948 5.697788156512011e-08 7.244293701844201 -0.07676008900768239 GKPTGEVEEMTEKPEMT(ph)AEEK ddPTM_A459_Selumetinib_30min_R1 1 GKPTGEVEEMTEKPEMTAEEK 21 2 B5MCA1;Q96G28;Q96G28-2 B5MCA1 CFAP36 Cilia- and flagella-associated protein 36 1 GKPTGEVEEMT(0.449)EKPEMT(0.551)AEEK 45.70399999999999 0.044002 0.0 71.433 145.66 258.05 190.68 187.04 146.02 0.0 165.05 82.324 0.0 True False 73.09724991557798 128.60605948450313 223.0082273671873 157.3813175069024 170.12226502459401 144.55117137555214 0.0 160.67233784204228 139.6978152929349 0.0 0.0 GKS(ph)EEELEASK ddPTM_A459_Selumetinib_30min_R1 2 GKSEEELEASK 11 1 Q7RTP6;J3QR21;A0A5F9ZHV5 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 GKS(0.755)EEELEAS(0.245)K;GKS(0.962)EEELEAS(0.038)K 146.84 0.0032137 24069000.0 2894.0 3624.8 3982.3999999999996 3835.8 3161.3999999999996 3097.4 2898.7 2684.3 1688.09 2470.24 True False 2961.424569256263 3200.406730876196 3441.6119537573586 3165.9495368836606 2875.451928190502 3066.242968214186 2680.04872524324 2613.1036441647643 2864.56543678454 2787.3193661752166 1.062463313387714 1.1482023802919368 1.234739009645661 1.1358402540100754 1.0316191115681952 1.1000687633515462 0.9615147649624469 0.9374970359964482 1.027713390703169 1.0 11.444662598047604 -6.735734129496168 1.2632255224910536 0.9795032309528521 1.1501778132803384 0.6106119007147721 0.054282976316826444 0.29669247431667906 0.996350499033423 0.027521070432416483 0.02541473642740221 1.8376629969782312e-07 6.735734129496168 0.17067458232748633 GKS(ph)EEELEASK ddPTM_A459_Selumetinib_30min_R2 1 GKSEEELEASK 11 1 Q7RTP6;J3QR21;A0A5F9ZHV5 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 GKS(1)EEELEASK 167.03 0.0026615 7416000.0 16490.0 20481.0 15440.0 18917.0 10775.0 10633.0 16051.0 15056.0 9651.7 12596.0 True False 15573.551814700195 22051.826843205334 14446.607209800934 16340.471966354813 9421.348170277814 12097.599233236304 16797.403304453106 15099.810467345018 11582.309691030185 12232.32075166167 1.273147764097393 1.802750867222784 1.1810193260210635 1.3358439741808668 0.7702012039700638 0.9889864301991047 1.373198401633746 1.2344191076982527 0.9468611824503388 1.0 13.578410521704543 -5.5850592268241614 2.240902008141546 1.0880490652325692 1.5302963363711402 0.38519863238860397 0.2148918802899375 0.31257793091856606 3.136472373100894 0.06282418155690057 0.14209339240122415 2.5998049910964835e-06 5.5850592268241614 0.442247271138571 GKS(ph)SPICSTTGDDK ddPTM_A459_Selumetinib_30min_R2 2 GKSSPICSTTGDDK 14 1 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GKS(0.5)S(0.5)PICSTTGDDK;GKS(0.652)S(0.347)PICSTTGDDK 81.317 0.017686 10638100.0 49495.0 38972.0 48861.0 49520.0 60524.0 46497.0 52031.0 57446.0 51817.0 43637.0 True False 46744.26604418352 41961.027085269234 45717.336455834375 42775.29057323524 52920.434028574884 52901.53969225885 54450.544597470565 57613.158349302714 62181.847887948345 42377.086427457936 1.1030552117876584 0.9901819738621974 1.0788220783912164 1.0093966853162253 1.2487983127194289 1.248352450629585 1.2849053388953544 1.359535617153063 1.4673459911972158 1.0 15.37099678035171 -6.356850222797538 3.81918825853452 1.2916271459943378 1.043403291628598 0.4696858525007169 0.11488818392999778 0.1951788601166737 5.219648734346721 0.03575069226312988 0.041231831598415536 4.3969322838640775e-07 6.356850222797538 -0.2482238543657398 GKSEVPEDLAGFIELFQT(ph)PSHTK ddPTM_A459_Selumetinib_30min_R1 1 GKSEVPEDLAGFIELFQTPSHTK 23 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 GKSEVPEDLAGFIELFQT(0.645)PS(0.302)HT(0.053)K 108.02 1.0479e-05 4539400.0 1690.2 3584.8 3666.9 4928.9 3252.0 3281.1 3435.9 3191.0 1966.5 2281.2 True False 1729.5783714433087 3165.0899494716928 3168.955120839909 4068.1601419119547 2957.8571741872306 3248.0951130004387 3176.72729674104 3106.3643141712023 3337.0068725226733 2574.014240769685 0.671938151719832 1.2296318720153094 1.231133484285745 1.580473051577014 1.1491223037300557 1.2618792318838101 1.2341529609374386 1.2068170661100668 1.2964212938949544 1.0 11.329804319973215 -4.760210427647872 5.235520430707031 1.25938790899319 0.6382449946764657 0.6084692099146871 0.13715606972717076 0.10556024355278529 8.29203411985018 0.03303044424065054 0.24018136564548329 1.736959020301286e-05 4.760210427647872 -0.6211429143167244 GKSS(ph)PICSTTGDDK ddPTM_A459_Selumetinib_30min_R2 1 GKSSPICSTTGDDK 14 1 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GKS(0.128)S(0.863)PICS(0.003)T(0.004)T(0.002)GDDK 70.944 0.030887 5082600.0 61123.0 40331.0 55398.0 58002.0 52179.0 48676.0 67531.0 58100.0 54096.0 47101.0 True False 57726.028354755625 43424.258015395484 51833.75299278187 50102.02754096912 45623.80753382146 55380.677163266264 70671.32531013791 58269.06138102725 64916.71156852877 45741.071746905094 1.2620173981529292 0.9493493780747198 1.133199354829044 1.0953400440242 0.9974363474967862 1.2107428848562867 1.545029939420246 1.2738892893337117 1.4192214805924641 1.0 15.481202549099441 -7.000477357191749 16.022073170942818 1.338864098241848 1.0848999366989711 0.31884716537014857 0.1509465222785838 0.18790582244733292 6031.847462071237 0.05018960028929371 0.04319136912958402 9.989014482964487e-08 7.000477357191749 -0.25396416154287693 GKYS(ph)PTVQTR ddPTM_A459_Selumetinib_30min_R2 1 GKYSPTVQTR 10 1 K7EKI8;O60437 K7EKI8 PPL Periplakin 1 GKY(0.013)S(0.954)PT(0.033)VQTR 120.03 0.024753 1567300.0 8666.3 7041.5 7482.1 10182.0 8354.7 6125.9 5996.1 9084.8 4891.7 6872.1 True False 8184.6617399476245 7581.560408008904 7000.709831894531 8795.194035070293 7305.10789403435 6969.687119616498 6274.930531046746 9111.235263930397 5870.176685517824 6673.684617139903 1.2264082301592596 1.1360381622675606 1.049002197963436 1.3178917703844975 1.0946138921927437 1.044353684577239 0.9402497856927425 1.3652481030539227 0.8796005538591913 1.0 12.704267794370928 -6.506492484695856 24.37581807817785 1.0629345257128402 1.1740979458497782 0.17705621312954878 0.13596797968564442 1086.195513589764 1615801.5023612203 0.04130319637526958 0.04559415015138322 3.1153548055611065e-07 6.506492484695856 0.11116342013693803 GLAAEDS(ph)GGDSK ddPTM_A459_Selumetinib_30min_R1 2 GLAAEDSGGDSK 12 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GLAAEDS(1)GGDSK;GLAAEDS(1)GGDSK 185.2 0.00010451 50380000.0 9519.7 12422.3 7218.1 7189.1 7900.2 8200.7 10778.9 9972.099999999999 5107.2 9849.2 True False 9741.490487888337 10967.891341029408 6237.921666185215 5933.658641120581 7185.628304893598 8118.208403639845 9965.83889485783 9707.607514054109 8666.545384870475 11113.440759332267 0.8765503590513258 0.986903298316443 0.5612952641104474 0.5339173321401764 0.6465709819760028 0.7304855966252178 0.8967374830777981 0.873501530649035 0.7798255799035897 1.0 13.440017928762119 -7.226695047700593 6.377781247170716 0.8770740727282874 0.7146489083261806 0.25716791398007144 0.13649494278246607 0.3341362692133373 43.30495185126794 0.059490865252960955 0.045075079823198125 5.9334181027196026e-08 7.226695047700593 -0.16242516440210686 GLAAEDS(ph)GGDSK ddPTM_A459_Selumetinib_30min_R2 2 GLAAEDSGGDSK 12 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GLAAEDS(1)GGDSK;GLAAEDS(0.999)GGDS(0.001)K 176.87 0.00010359 75484000.0 312490.0 230566.0 279000.0 313780.0 322880.0 259150.0 333210.0 349220.0 315030.0 248237.0 True False 295123.05679658335 248249.67081346008 261049.44375223137 271042.62269930844 282316.9278161768 294845.5601705246 348704.92524308944 350236.17238351714 378044.8026736472 241069.7528128164 1.224222671459483 1.0297835705926104 1.0828792940893277 1.1243327689880906 1.1711005819771492 1.2230715663423088 1.4464897448741676 1.4528416290179103 1.5681967491259174 1.0 17.87909112079638 -7.004916673004471 2.3413481497887947 1.40450959397538 1.1153068892194025 0.3558044137845291 0.14803850860576911 0.27636921505429485 3.037993244006329 0.05959353328564685 0.0469900301001762 9.887427840626357e-08 7.004916673004471 -0.28920270475597754 GLAAEDS(ph)GGDSKDLSEVSETTESTDVK ddPTM_A459_Selumetinib_30min_R1 2 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GLAAEDS(0.848)GGDS(0.152)KDLS(0.001)EVSETTESTDVK;GLAAEDS(0.991)GGDS(0.009)KDLSEVSETTESTDVK 125.08 4.1128e-12 36730000.0 2272.45 2506.3 2035.82 2496.42 1621.49 2087.4900000000002 2147.6000000000004 2223.54 1439.76 1984.46 True False 2325.3936635820287 2212.8612308527413 1759.366825958794 2060.467110607202 1474.8265157973117 2066.4917458892724 1985.6048029573208 2164.5644961241737 2443.1675640901294 2239.1847712773133 1.0385001244249883 0.9882441410096068 0.7857175738807773 0.9201862825423897 0.6586444025144099 0.9228768310667232 0.8867534418897726 0.9666752489074077 1.0910969007244797 1.0 11.128757864932512 -7.940013653464423 2.9158551775130785 1.0448166052013506 0.8792931728138246 0.28431441243309197 0.10139789783654289 0.347704609017131 5.802651772693156 0.07419257559448326 0.028750714661557247 1.148117526108014e-08 7.940013653464423 -0.16552343238752598 GLAAEDS(ph)GGDSKDLSEVSETTESTDVK ddPTM_A459_Selumetinib_30min_R2 2 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GLAAEDS(0.945)GGDS(0.051)KDLS(0.002)EVS(0.001)ETTESTDVK;GLAAEDS(0.872)GGDS(0.126)KDLS(0.002)EVSETTESTDVK 89.079 2.08e-05 22843000.0 60112.8 49912.7 52423.0 50425.3 41709.9 36307.8 42977.6 43921.4 32220.5 52768.3 True False 56771.97122660459 53740.84359537399 49050.16125384676 43557.28715150563 36469.92947076294 41308.86988060728 44976.14355849878 44049.20400242079 38665.500315989724 51244.742070491295 1.1078594394818135 1.04870941727932 0.9571745172680212 0.8499854890788416 0.7116813939778562 0.8061094311643443 0.8776733327417366 0.8595848514922281 0.7545261963227797 1.0 15.645116365085169 -5.475735956438862 1.9668208915160472 0.8253213878892429 1.091403242640385 0.6362214520616631 0.0735220624060889 0.21100959630355046 1.5709905948373994 0.021233720235458758 0.05969869185875142 3.3439828663048285e-06 5.475735956438862 0.2660818547511421 GLAAEDSGGDS(ph)KDLSEVSETTESTDVK ddPTM_A459_Selumetinib_30min_R2 1 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GLAAEDS(0.189)GGDS(0.768)KDLS(0.04)EVS(0.001)ET(0.001)T(0.001)ES(0.001)TDVK 58.418 0.0036742 3007700.0 8239.7 8148.9 7980.9 6980.3 9725.5 8409.9 8030.0 6754.0 4634.1 8587.8 True False 7781.770460132516 8773.894427156682 7467.417582946902 6029.571098310865 8503.695742926859 9568.287387528817 8403.410911143143 6773.653021815109 5561.049487572445 8339.847900215947 0.9330830194074665 1.052044897237214 0.8953901404788863 0.7229833409977103 1.019646382604492 1.1472975888782169 1.007621603138056 0.8122034241943089 0.6668046652779424 1.0 13.025805357108387 -7.772374781505556 23.52299529629513 0.8046278216598913 0.9681370421689816 0.1965683204684473 0.1293040651058931 164.6924860697156 354256.20013153454 0.07335142663468652 0.035853114646068725 1.6889827673377153e-08 7.772374781505556 0.16350922050909023 GLAEVQQDGEAEEGAT(ph)SDGEKKR ddPTM_A459_Selumetinib_30min_R2 1 GLAEVQQDGEAEEGATSDGEKKR 23 2 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 GLAEVQQDGEAEEGAT(0.565)S(0.435)DGEKKR 64.002 0.015962 23368000.0 69643.0 101250.0 74938.0 87669.0 78376.0 36449.0 28597.0 24126.0 16126.0 85291.0 True False 65772.5208630179 109015.54942993699 70116.57066632534 75728.33096253939 68529.70618966999 41469.51889892126 29926.8171638805 24196.20266572569 19351.650598086642 82828.42721736869 0.7940814895640773 1.3161610463017097 0.8465278530801591 0.9142794751348309 0.8273694007230848 0.5006677090474237 0.36131094322656654 0.2921243766011275 0.23363537432989795 1.0 16.337838373928264 -6.659894659050054 1.8391473475743296 0.40748530273735944 0.9930717828618842 0.48381510850493303 0.23825100984570133 0.2559720404866818 1.7802063116952653 0.0905317830989583 0.08918825727947119 2.188292344116351e-07 6.659894659050054 0.5855864801245247 GLAEVQQDGEAEEGATS(ph)DGEK ddPTM_A459_Selumetinib_30min_R1 1 GLAEVQQDGEAEEGATSDGEK 21 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 GLAEVQQDGEAEEGAT(0.267)S(0.733)DGEK 104.77 0.00010037 48624000.0 5798.7 7931.2 6038.8 5618.6 5364.3 6277.7 6266.5 6489.3 3877.6 6062.5 True False 5933.798427693952 7002.61141688515 5218.764128754001 4637.416984184403 4879.10001214409 6214.5520376955465 5793.812859811907 6317.182683782884 6580.003991301252 6840.680928750745 0.8674280366965736 1.0236716914326214 0.76290126423234 0.6779174518568424 0.7132477107122023 0.908469800363932 0.8469643475784774 0.9234727872239082 0.9618931302066887 1.0 12.739924224340083 -7.895925124271243 1.2486631932056365 0.9930565346160406 0.8189173486718089 0.32366139269960104 0.09258949266265597 0.6408401499893749 1.7996418283160693 0.09211297487737545 0.03324570892436181 1.2707931808991662e-08 7.895925124271243 -0.17413918594423172 GLAEVQQDGEAEEGATS(ph)DGEK ddPTM_A459_Selumetinib_30min_R2 2 GLAEVQQDGEAEEGATSDGEK 21 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 GLAEVQQDGEAEEGAT(0.042)S(0.958)DGEK;GLAEVQQDGEAEEGAT(0.373)S(0.627)DGEK 206.69 8.8967e-18 48694000.0 388710.0 304560.0 342640.0 324330.0 323710.0 265280.0 354160.0 346410.0 236710.0 319100.0 True False 367107.0543294182 327918.77268525056 320594.91543822456 280155.694499543 283042.6557958821 301819.9120279252 370629.1417547261 347417.99574873777 284058.61423000664 309886.75387863093 1.1846490685213282 1.0581890596513912 1.0345550799624934 0.904058308375671 0.9133744900459266 0.9739684199155374 1.1960147928745781 1.1211127658744853 0.9166529729801228 1.0 18.241381562623168 -4.7547065714531485 2.140567445496959 1.010665478363954 1.2389691756635173 0.26900808290231804 0.08841649077529522 1.1700833580131282 5.774884588327235 0.02618283281548078 0.534242258329988 1.7591117461808314e-05 4.7547065714531485 0.22830369729956335 GLAEVQQDGEAEEGATS(ph)DGEKKR ddPTM_A459_Selumetinib_30min_R1 4 GLAEVQQDGEAEEGATSDGEKKR 23 2 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 GLAEVQQDGEAEEGAT(0.145)S(0.855)DGEKKR;GLAEVQQDGEAEEGAT(0.158)S(0.842)DGEKKR;GLAEVQQDGEAEEGAT(0.253)S(0.747)DGEKKR;GLAEVQQDGEAEEGAT(0.391)S(0.609)DGEKKR 81.15100000000002 0.00020192 372738000.0 19569.4 13764.5 42998.0 41514.6 23989.6 24070.6 16086.2 18225.2 14338.2 13293.4 True False 20025.328944576206 12152.945941057562 37159.10777110759 34264.85443555722 21819.744915707888 23828.471618356136 14872.804982926074 17741.80849220714 24330.878179305655 14999.737378681262 1.3350453037289631 0.810210581308592 2.477317224494935 2.284363623876307 1.454675129627251 1.588592587775765 0.9915376921241572 1.182807941519237 1.6220869449278825 1.0 13.872649621217874 -6.999487113093658 2.7162688289380226 1.2177134393851674 1.7046793603607096 0.1816992571649504 0.47012463405937155 0.5409353491342279 8.060389476573066 0.20848158522215146 0.16741803064386082 1.0011816633595724e-07 6.999487113093658 0.48696592097554214 GLAEVQQDGEAEEGATS(ph)DGEKKR ddPTM_A459_Selumetinib_30min_R2 2 GLAEVQQDGEAEEGATSDGEKKR 23 2 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 GLAEVQQDGEAEEGAT(0.076)S(0.924)DGEKKR;GLAEVQQDGEAEEGAT(0.446)S(0.554)DGEKKR 102.16 4.1628e-05 37340000.0 33859.5 49581.0 33981.0 39865.0 32612.0 17156.7 8653.4 10367.0 8854.3 32755.8 True False 31977.724540317853 53383.703271957624 31794.699455715363 34435.31822903923 28514.98900502088 19519.87969198394 9055.8002463868 10397.166253650754 10625.407409812631 31810.0549442108 1.0052709621659288 1.67820217115573 0.999517275637456 1.0825293539867402 0.8964143273260962 0.6136386663342251 0.2846835776382364 0.3268515653897971 0.33402669151146436 1.0 14.957195243337344 -6.4759593151041015 1.250483528243906 0.42657450224915666 1.2753747888724918 0.6021720299824636 0.26148501811932723 0.2705383140790245 0.878694348053586 0.10970246416631195 0.12906795564335963 3.342263490292715e-07 6.4759593151041015 0.8488002866233351 GLAGPPAS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 2 GLAGPPASPGK 11 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 GLAGPPAS(1)PGK;GLAGPPAS(1)PGK 126.5 0.0031469 155733000.0 13037.3 17172.3 16676.4 16826.4 12055.3 13222.400000000001 13881.7 13524.900000000001 8401.6 12444.3 True False 13341.043723830218 15161.75913281432 14411.836476908198 13887.985110646858 10964.900243536089 13089.394660978645 12834.592192779206 13166.175716933281 14256.90157141444 14041.647122746874 0.9501053264768556 1.0797706992830574 1.0263636702251002 0.9890566960729921 0.7808841902723375 0.9321837065520882 0.9140375114531764 0.9376518012338192 1.0153297150103469 1.0 13.777424557103624 -6.012261359024625 24.939699059569588 0.9224579400481121 1.0219925351299037 0.2703287918790094 0.06603226914487821 686.8853830565317 1397134.050974512 0.01920344746191094 0.026193705559998982 9.721619992537957e-07 6.012261359024625 0.09953459508179163 GLAGPPAS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 3 GLAGPPASPGK 11 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 GLAGPPAS(1)PGK;GLAGPPAS(1)PGK;GLAGPPAS(1)PGK 112.5 0.0076375 260930000.0 891210.0 821300.0 803280.0 812820.0 772160.0 494209.0 774080.0 702620.0 498160.0 708060.0 True False 841680.1159962979 884291.0691042696 751597.8393451344 702112.513807291 675154.3576020158 562281.8037673725 810076.2538104203 704664.5078749969 597805.9197533695 687616.468039183 1.2240546221885074 1.2860236922857982 1.0930480497193467 1.0210815860903466 0.9818763641995017 0.8177259124854637 1.1780931543429223 1.0247929487268221 0.8693886018438178 1.0 19.391244571425503 -5.500268617009109 2.2401852330084933 0.9846325716011384 1.2592537603027842 0.5766240328145671 0.09189156269468625 0.22794028283963286 2.239715013008572 0.026946695770398148 0.06750725793194617 3.160322353432891e-06 5.500268617009109 0.27462118870164587 GLAPDLPEDLYHLIK ddPTM_A459_Selumetinib_30min_R1 1 GLAPDLPEDLYHLIK 15 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 145.43 0.00051008 19672000.0 2054.5 2852.7 2156.7 2021.0 2969.7 1869.5 2161.0 1741.0 1556.8 2056.1 False True 2102.3658526389045 2518.704557815751 1863.831985905106 1668.0702888685223 2701.0911593431183 1850.694527370186 1997.9940301689198 1694.823024434993 2641.775895826745 2320.020463110006 0.9061841850397587 1.0856389406321905 0.8033687700351678 0.718989472460282 1.1642531616821534 0.7977061223370915 0.8611967273299792 0.7305207222884014 1.1386864632587868 1.0 11.179921814970594 -8.279907701752636 24.877007959044004 1.06934324137436 0.8878242420969433 0.22062986070080004 0.13953862910617876 1400.7329567835932 1886781.6712494607 0.1324794866460857 0.03447313221258 5.2491900658155045e-09 8.279907701752636 -0.18151899927741666 GLAPNT(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 GLAPNTPGK 9 0 O43663-3;O43663-2;O43663-4;O43663;G3V3N7;H0YL53 O43663-3 PRC1 Protein regulator of cytokinesis 1 1 GLAPNT(1)PGK 98.182 0.046603 133950000.0 830260.0 869990.0 770190.0 902260.0 794410.0 685550.0 700790.0 683150.0 617010.0 701520.0 True False 784117.4729941174 936715.4355412443 720636.8139194659 779370.6315146835 694609.1136844911 779978.289696713 733378.1235890407 685137.8533984295 740429.2406998269 681265.2948321446 1.1509722848678419 1.3749642652383158 1.0577917580507634 1.1440046005964692 1.019586817284791 1.1448965558841362 1.0764941780422501 1.005684362018234 1.0868442093212154 1.0 19.377857188983704 -5.281214214032032 24.945129513534432 1.071306201843273 1.2629682759866536 0.5594735188413117 0.06950071223538594 464.98126295821197 586553.9169884493 0.016979654428369666 0.03542209513363728 5.2334223642883884e-06 5.281214214032032 0.19166207414338055 GLAPPPPTS(ph)ASPSLLSNRPPPPAR ddPTM_A459_Selumetinib_30min_R2 2 GLAPPPPTSASPSLLSNRPPPPAR 24 1 Q8TF74-2;Q8TF74 Q8TF74-2 WIPF2 WAS/WASL-interacting protein family member 2 1 GLAPPPPT(0.065)S(0.497)AS(0.388)PS(0.046)LLS(0.004)NRPPPPAR;GLAPPPPT(0.049)S(0.432)AS(0.432)PS(0.043)LLS(0.043)NRPPPPAR 86.006 5.5313e-05 22465000.0 75400.0 68351.0 78260.0 87085.0 88934.0 62624.0 65445.0 78347.0 67826.0 67650.0 True False 71209.56985011497 73593.30191689503 73224.83680304536 75223.87276999572 77761.31583995232 71249.8875559288 68488.32217680731 78574.9767989559 81393.09521678179 65696.76872419132 1.0839128199602561 1.1201966755146664 1.11458810265781 1.1450163262336563 1.1836398859494974 1.0845265138541382 1.0424914878893894 1.1960249845594382 1.238920829706053 1.0 16.003534793320398 -4.510602481224778 1.4096125265690125 1.1313347909250917 1.0354585042323194 0.028070233481261586 0.06800802316407394 9.799929232137329 10.876135356937256 0.019739218171912484 1.5981357992739929 3.0860113482894244e-05 4.510602481224778 -0.09587628669277226 GLAS(ph)PTAITPVASPICGK ddPTM_A459_Selumetinib_30min_R2 1 GLASPTAITPVASPICGK 18 0 O95425-3;O95425;A0A6I8PIX7;A0A0J9YWY6;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 GLAS(0.59)PT(0.41)AITPVASPICGK 145.46 0.00026901 5302900.0 15870.0 13871.0 15668.0 18608.0 14189.0 11855.0 12448.0 16135.0 13522.0 14192.0 True False 14988.008932643543 14934.861097705263 14659.937938028563 16073.558299409551 12406.450968730578 13487.91864102477 13026.856665244064 16181.950178706953 16226.777836247526 13782.24008475567 1.0874871458103212 1.0836308906143994 1.0636832508993732 1.1662515092294956 0.9001766688459569 0.9786448761652001 0.9451915352753778 1.1741161145934156 1.1773686814667903 1.0 13.750522773870197 -10.420103439433083 7.546029718280795 0.9999999998502103 1.0600396136565944 0.04017866137788917 0.09206251243869772 5.445854044419713e-10 3.116951885173167e-18 0.09520459793938729 0.023090506667562075 3.800988543167702e-11 10.420103439433083 0.06003961380638412 GLCAIAQAESLR ddPTM_A459_Selumetinib_30min_R2 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YF32;H0YCJ7 P23396 RPS3 40S ribosomal protein S3 0 139.43 0.040239 0.0 7920.9 10865.0 10870.0 11881.0 13742.0 7163.1 6232.3 9277.9 6911.0 10423.0 False True 7480.688087875004 11698.310563518686 10170.63603436115 10262.787304131816 12015.607104961271 8149.752004852345 6522.114299068164 9304.89715296097 8293.393109473942 10122.060907793713 0.7390479227520828 1.1557241820696122 1.0047989364033598 1.013902939097091 1.1870712115266544 0.8051474970455134 0.6443464782993266 0.9192690340162298 0.8193383921537415 1.0 13.305215440208837 -6.791944137757377 24.997940416250614 0.8204948461235775 1.0264479091313368 0.29079518112869185 0.14106049240352392 233.0142236560847 190948.13601491498 0.0481200398398779 0.04244263236244155 1.614566221195513e-07 6.791944137757377 0.20595306300775928 GLDDDRGPWR ddPTM_A459_Selumetinib_30min_R1 1 GLDDDRGPWR 10 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 131.52 0.0073164 16623000.0 4701.4 5290.0 4249.6 4536.3 5053.2 4502.2 4654.1 4601.7 2622.9 4001.5 False True 4810.933472668069 4670.644340745719 3672.5276613818965 3744.120361897218 4596.138952214921 4456.911955670532 4303.037489962592 4479.6479675718 4450.869730963497 4515.131502910698 1.0655134783043818 1.0344425932522163 0.8133822146740104 0.8292383864088024 1.0179413266816262 0.9871056807088265 0.9530259500058019 0.9921411955961806 0.9857674639363717 1.0 12.140552291379146 GLDDDRGPWR ddPTM_A459_Selumetinib_30min_R2 1 GLDDDRGPWR 10 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 122.94 0.012142 7688200.0 51174.0 43303.0 46648.0 50501.0 60361.0 43780.0 41594.0 50276.0 36670.0 49202.0 False True 48329.953945753026 46624.20085890929 43646.71846650219 43622.67668091583 52777.91154581338 49810.29760472915 43528.20341694741 50422.29483636015 44005.02464540724 47781.410417851526 1.011480270739278 0.975781176218484 0.9134665152160394 0.9129633533090107 1.1045699799203734 1.0424618521959665 0.9109861562538747 1.0552701227404953 0.9209653767140914 1.0 15.54416181963101 -4.751933319066508 22.74093619188568 0.9827847383476735 1.0114804470149057 0.018029023645528053 0.06530640221099247 773.3545563241755 1849621.6565381791 0.01660722321924692 0.19161514412497704 1.770380759098632e-05 4.751933319066508 0.028695708667232145 GLDDTEEPS(ph)PPEDK ddPTM_A459_Selumetinib_30min_R1 1 GLDDTEEPSPPEDK 14 0 O94806;O94806-2 O94806 PRKD3 Serine/threonine-protein kinase D3 1 GLDDTEEPS(1)PPEDK 162.94 0.00027183 5497000.0 1622.0 1785.7 1652.6 1752.5 1496.1 1456.1 1494.8 1652.9 945.98 1654.7 True False 1659.7894441374078 1576.6294138505932 1428.1859970820137 1446.4587734992995 1360.7780191579081 1441.4529560330193 1382.0460325296149 1609.0597226241246 1605.2589683544347 1867.096863142906 0.8889680427953078 0.844428291308162 0.7649233552232162 0.7747100871159188 0.7288202588843166 0.7720290170733857 0.7402112122898652 0.8617976680200595 0.8597620188018974 1.0 10.866581059762872 -8.59015003259032 1.3147422352050653 0.9975762640403271 0.7874947086112146 0.6271413042742942 0.04847432572720662 0.3611100437333734 1.3486251575095543 0.049743358107313895 0.015077552513528278 2.569507959993095e-09 8.59015003259032 -0.21008155542911244 GLDDTEEPS(ph)PPEDK ddPTM_A459_Selumetinib_30min_R2 2 GLDDTEEPSPPEDK 14 0 O94806;O94806-2 O94806 PRKD3 Serine/threonine-protein kinase D3 1 GLDDTEEPS(1)PPEDK;GLDDTEEPS(1)PPEDK 173.33 1.1369e-09 0.0 54917.0 42954.0 45424.0 49428.0 47196.0 33735.0 46002.0 43448.0 33071.0 37502.0 True False 51864.9329901692 46248.43368112116 42501.46929391173 42695.82113194406 41266.816542406676 38381.69003416033 48141.18415123372 43574.42648679641 39686.12408094526 36419.21981810224 1.42410884278168 1.269890840938149 1.1670065835069399 1.1723431019442658 1.1331054522451611 1.0538855644316314 1.3218620385521014 1.1964678734039673 1.0897027525345064 1.0 15.152412396410854 -4.745831255568528 1.432585491123797 1.149347264595816 1.5554208296351246 0.5390505096074336 0.08227980236918774 1.0724760887064309 1.8924649062136116 0.023757203213202842 0.6452607276515827 1.7954311032268708e-05 4.745831255568528 0.4060735650393086 GLDIESYDS(ph)LERPLR ddPTM_A459_Selumetinib_30min_R1 2 GLDIESYDSLERPLR 15 1 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 GLDIESYDS(1)LERPLR;GLDIES(0.001)YDS(0.999)LERPLR 114.58 0.0013647 9550000.0 4214.3 5926.0 3686.0 4258.2 4529.1 4172.2 5196.299999999999 4744.2 2347.23 4242.3 True False 4312.484990399676 5232.181165077341 3185.4614457487014 3514.5853063136774 4119.443704677549 4130.231456054504 4804.338907434866 4618.36840466657 3983.0778751036814 4786.840528501328 0.9009042529665879 1.09303435824202 0.6654622034684767 0.7342181727984219 0.8605767583335958 0.8628303849820549 1.003655517418922 0.9648051522018213 0.8320891100064932 1.0 12.224858028766022 -7.122966266369238 6.455082271386963 0.9468670588360183 0.8489006155115731 0.15010276490645957 0.11349735215531083 0.5384641733737003 26.17111718460338 0.046719000220070694 0.036144675562361006 7.534140825648153e-08 7.122966266369238 -0.09796644332444515 GLDIESYDS(ph)LERPLRK ddPTM_A459_Selumetinib_30min_R1 1 GLDIESYDSLERPLRK 16 2 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 GLDIES(0.015)Y(0.001)DS(0.985)LERPLRK 52.52 0.040599 4752700.0 1885.9 1794.9 2248.0 2582.2 2263.2 2058.7 2037.1 1675.6 1118.7 1910.1 True False 1929.8378006773962 1584.7522735736277 1942.7339473801085 2131.2672438972263 2058.4939596004133 2037.9913471500408 1883.4399069213798 1631.157644884132 1898.352193384751 2155.279940949575 0.8954000656764552 0.7352883694892164 0.9013835792134627 0.9888586644379155 0.9550935451538051 0.945580807592048 0.8738725170390498 0.7568193875388063 0.88079147275336 1.0 11.073659552208499 -5.418437302771745 10.482787341782615 0.9086203920481262 0.8155704090766233 0.21199343578359797 0.07493887639414085 0.7826823071345985 74.17487060163393 0.02097842036996269 0.043701409996653694 3.815598744630691e-06 5.418437302771745 -0.09304998297150291 GLDS(ph)GAETEEEKDTWEEK ddPTM_A459_Selumetinib_30min_R2 1 GLDSGAETEEEKDTWEEK 18 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GLDS(0.957)GAET(0.043)EEEKDTWEEK 70.987 0.012436 7245400.0 27487.0 18906.0 27852.0 24050.0 20102.0 10045.0 21196.0 19378.0 13372.0 20805.0 True False 25959.38257917914 20356.029407628543 26060.032642964725 20774.348511435936 17576.607045839875 11428.60757056886 22181.65599907721 19434.386771799393 16046.773644897337 20204.30559211821 1.2848440873566083 1.0075094793443196 1.289825701959827 1.0282139327540216 0.8699436348209161 0.5656520843273728 1.0978677736754474 0.9618933292803111 0.7942254472312702 1.0 14.302375147501253 -6.035033635498881 3.8540195759199274 0.8768546130961227 1.17561680609912 0.45872557313374707 0.15148075337455288 0.21296088300843113 6.7627441595270925 0.04574048562442704 0.06402966251427315 9.224999780577322e-07 6.035033635498881 0.2987621930029972 GLDSGAET(ph)EEEKDTWEEK ddPTM_A459_Selumetinib_30min_R2 1 GLDSGAETEEEKDTWEEK 18 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GLDS(0.362)GAET(0.638)EEEKDTWEEK 66.289 0.043913 7275000.0 26005.0 26982.0 19682.0 26515.0 25680.0 15437.0 20250.0 21846.0 14868.0 20126.0 True False 24559.746206263102 29051.43263919567 18415.681548141307 22903.61125907376 22453.848817887185 17563.306626866244 21191.66512461376 21909.568243200018 17842.015446629808 19544.91008637209 1.2565801580938285 1.4863937726401777 0.9422239072351554 1.1718453120459 1.1488335693876324 0.8986128127093539 1.084254930361122 1.1209858805375992 0.9128727309454525 1.0 14.254505327274966 -5.26271840865182 24.998498569870726 1.0451221381315499 1.3714869744061091 0.6167523323085413 0.10587144945969018 67.62940972020927 1321840.1512326652 0.026687629909010118 0.06098127023485592 5.461118387065097e-06 5.26271840865182 0.32636483627455926 GLDSSSTAPS(ph)ALGER ddPTM_A459_Selumetinib_30min_R1 1 GLDSSSTAPSALGER 15 0 J3KTM2;O15534-4;O15534;J3QL46 J3KTM2 PER1 Period circadian protein homolog 1 1 GLDSSS(0.001)TAPS(0.999)ALGER 116.58 0.0022404 5416300.0 622.02 527.34 659.32 702.05 428.92 878.42 789.18 879.2 536.55 553.14 True False 636.5118557597722 465.59878764628513 569.7879653855215 579.450146610661 390.12426173197656 869.5838923415461 729.6515172275368 855.8807599559136 910.4861619384897 624.1409070398665 1.0198207625559712 0.7459834508436496 0.9129155915895234 0.9283963606212549 0.6250579914433612 1.3932493168341584 1.1690493428608597 1.3712941265380718 1.4587830274684 1.0 9.28572796075142 -6.771504697843366 24.999540738285184 1.2948419881506203 0.8491009826256333 0.6546052331652937 0.15668288589480867 120.60806472792535 299556.1727832493 0.05244308234854131 0.04677910255824598 1.6923699376602155e-07 6.771504697843366 -0.4457410055249871 GLDVDSLVIEHIQVNK ddPTM_A459_Selumetinib_30min_R2 1 GLDVDSLVIEHIQVNK 16 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2;J3KRB3;A0A087WWH0;J3QS96 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 132.65 0.00088006 0.0 7900.8 9087.4 9947.7 6944.4 7301.0 7610.6 5341.4 6487.9 6473.2 8533.1 False True 7461.70516540833 9784.374359403559 9307.675812236836 5998.560740241816 6383.783108231863 8658.891067851797 5589.785683783306 6506.778714870335 7768.02087631988 8286.727231343619 0.9004405427012566 1.1807284210339708 1.1232028703722252 0.7238757319720783 0.7703624036381839 1.0449108346538196 0.6745468419233792 0.7852048864670207 0.9374051612243504 1.0 13.01658671939083 -5.751254070893398 24.99991511803725 0.8368309360283386 1.0793844507547354 0.370841545189602 0.13054751380499052 199.96113230951616 490801.47019886476 0.034902102927967076 0.05958298960216756 1.7731518483705691e-06 5.751254070893398 0.24255351472639686 GLEERLS(ph)PPLPHEER ddPTM_A459_Selumetinib_30min_R2 1 GLEERLSPPLPHEER 15 1 Q9UPV0 Q9UPV0 CEP164 Centrosomal protein of 164 kDa 1 GLEERLS(1)PPLPHEER 54.004 0.04615 2302400.0 10691.0 11615.0 9705.0 12450.0 13995.0 7760.1 7793.4 8728.7 8021.1 11345.0 True False 10096.837019463906 12505.833151888579 9080.59086600505 10754.288522552068 12236.822983112577 8828.983335825924 8155.808542329135 8754.099071885927 9625.544128259502 11017.440372150022 0.9164412675186131 1.1350942441677223 0.8242014986492728 0.9761149740130973 1.1106774867640692 0.8013642949358638 0.7402634610980474 0.7945674109582305 0.873664281641227 1.0 13.427501468128833 -6.785091880379347 24.99988032115374 0.8227755119059869 0.9901666409347096 0.33091272437996466 0.10524485071104138 248.5426837293597 262699.1480737495 0.036267122748733366 0.032002296165024674 1.640242722815821e-07 6.785091880379347 0.16739112902872277 GLEGKS(ph)PDTGPDWLK ddPTM_A459_Selumetinib_30min_R2 1 GLEGKSPDTGPDWLK 15 1 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 GLEGKS(0.999)PDT(0.001)GPDWLK 76.068 0.020613 4886200.0 28652.0 24467.0 28444.0 24208.0 23339.0 17082.0 19129.0 18992.0 15018.0 25373.0 True False 27059.636543043674 26343.54022619526 26613.94400748559 20910.828638870735 20406.94616669272 19434.890445043035 20018.536403394417 19047.263575705136 18022.019637979978 24640.415563028873 1.0981810137830899 1.0691191534010407 1.0800931477559108 0.8486394470654095 0.8281900162963095 0.78874036825108 0.8124268988965736 0.7730090236093319 0.7314007993039163 1.0 14.588738966981019 -5.797142312047584 4.033800625858308 0.8110598866531544 1.0847146448199558 0.7539730465449397 0.06702878076619424 0.09266542232432212 3.229222076892472 0.0181994661196768 0.029476082866546044 1.595356286293606e-06 5.797142312047584 0.2736547581668014 GLEGNANS(ph)PAHLR ddPTM_A459_Selumetinib_30min_R1 2 GLEGNANSPAHLR 13 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 GLEGNANS(1)PAHLR;GLEGNANS(1)PAHLR 108.23 0.0063463 22491000.0 4966.0 6866.9 5033.7 5640.2 6052.3 5600.4 6654.9 5701.8 3511.7999999999997 5662.0 True False 5081.698137846094 6062.9201556647995 4350.151188134897 4655.244949666619 5504.870533620354 5544.065060756347 6152.9155351092695 5550.569741943395 5959.268108276189 6388.772852550391 0.7954106766869143 0.9489960428385693 0.6809055961972919 0.7286602696804677 0.8616475590336282 0.8677824660088146 0.9630825319846882 0.8688006085124178 0.9327719494514907 1.0 12.641323131396616 -6.770614392936974 2.1101236606868903 0.928483047166505 0.7941984026089286 0.444927110582499 0.07331984999607442 0.33756685613371723 3.091793104906816 0.03024428776109989 0.027661525095484203 1.6958428593139835e-07 6.770614392936974 -0.13428464455757638 GLEGNANS(ph)PAHLR ddPTM_A459_Selumetinib_30min_R2 2 GLEGNANSPAHLR 13 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 GLEGNANS(1)PAHLR;GLEGNANS(1)PAHLR 130.66 0.0016026 23677100.0 98311.0 82148.0 108086.0 107939.0 119439.0 77076.0 77649.0 100595.0 82001.0 81011.0 True False 92847.26819011457 88448.4874525477 101131.86443513905 93237.52199483915 104434.00502179233 87692.5193737346 81259.83235857463 100887.71479560134 98403.4912993739 78672.00193814396 1.180181842367707 1.1242689301600655 1.2854873645474816 1.1851423593891428 1.327460881240874 1.1146598181483043 1.032893918505663 1.2823839779102675 1.250807007259633 1.0 16.263562675362493 GLEPS(ph)PAAVAALPPEVR ddPTM_A459_Selumetinib_30min_R2 1 GLEPSPAAVAALPPEVR 17 0 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 GLEPS(1)PAAVAALPPEVR 96.435 0.0059941000000000005 2588800.0 11542.0 11004.0 11554.0 12096.0 13749.0 9941.2 9610.0 12602.0 9683.1 14768.0 True False 10900.541846286817 11847.97141656323 10810.628219044038 10448.503933236128 12021.727702380476 11310.510062771438 10056.884041853747 12638.669733626588 11619.990568419495 14341.60946812794 0.7600640549104076 0.8261256480936506 0.7537946311443654 0.7285447255035322 0.8382411840942225 0.7886499829679046 0.7012381744324898 0.8812588128071763 0.8102291862181277 1.0 13.807919317214907 -9.002399154623815 0.7940093893368256 1.0014295431696865 0.7757790159885872 0.6458021568748964 0.04863978270976375 0.989380822503402 1.0227660331095338 0.04993588507983148 0.016451269743179002 9.944909729799104e-10 9.002399154623815 -0.22565052718109924 GLEYLYLNVHDEDRDDQTR ddPTM_A459_Selumetinib_30min_R1 1 GLEYLYLNVHDEDRDDQTR 19 1 Q9Y6G9;C9JGM7;C9JLW1 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 0 124.43 0.00032277 4859700.0 3177.4 3608.8 3376.1 2997.8 3122.8 2976.6 2744.6 2844.5 1580.4 2341.9 False True 3251.4272378558567 3186.2800183143977 2917.6441635898495 2474.2905056754366 2840.3432913751208 2946.6581065365613 2537.5726123098625 2769.0546197618246 2681.8233721509446 2642.505677037754 1.2304333974035973 1.2057798195106297 1.1041203010244902 0.936342550623813 1.0748674320954128 1.1151000098663029 0.9602903162556224 1.0478897524511401 1.0148789444256807 1.0 11.367690855693098 -5.39211090256297 3.197352784941182 1.026510978297509 1.2208682530706283 0.7073524438309882 0.05008393691538914 0.13553520048750098 2.572472645861624 0.013708660042608562 0.03286605516568053 4.0540499695969735e-06 5.39211090256297 0.19435727477311926 GLFIIDDK ddPTM_A459_Selumetinib_30min_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 136.16 0.036184 23840000.0 4389.3 4812.4 5027.7 5488.1 4403.2 4305.6 4249.7 4367.3 4072.9 4266.0 False True 4491.562149908957 4248.961970775935 4344.965955179258 4529.706359396008 4004.9313374481017 4262.289573172013 3929.141707546901 4251.46501701031 6911.413827153615 4813.58265435888 0.933101698345551 0.8827026096515326 0.9026470026944958 0.9410259851452201 0.8320063505757994 0.8854713587004368 0.8162613981477841 0.8832226061726495 1.4358149269328677 1.0 12.232895347831441 -8.233629202913276 24.287016198894143 1.2179074069862597 0.882981010240857 0.6214506929903003 0.10406327533286969 249.6815855244216 218051.1679453651 0.06363147934626993 0.024037059112533447 5.839434576601934e-09 8.233629202913276 -0.3349263967454027 GLFIIDDK ddPTM_A459_Selumetinib_30min_R2 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 151.27 0.016158000000000002 21580000.0 165920.0 172100.0 165090.0 194190.0 153940.0 122320.0 152160.0 144350.0 114980.0 119630.0 False True 156698.8306303856 185299.5166112804 154468.289136401 167740.98700356527 134600.68095893887 139168.46968959505 159235.7414993202 144770.03460157098 137979.21280962412 116175.97106393214 1.3488058605867264 1.594990038941093 1.3296061803640653 1.4438526785479304 1.158593121505888 1.1979109657108873 1.3706426556287794 1.2461271748002296 1.1876742801976974 1.0 16.825952178190242 -1.522879079390179 0.05599871371276816 0.5037072801473639 2.8728539325336317 0.5964437876896336 0.10052699922659131 271.265565849683 1.144164458691904 10.431020202582044 53.52102817680894 0.02999997692051867 1.522879079390179 2.369146652386268 GLFQDEDS(ph)CSDCSYR ddPTM_A459_Selumetinib_30min_R1 2 GLFQDEDSCSDCSYR 15 0 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 GLFQDEDS(0.992)CS(0.008)DCSYR;GLFQDEDS(0.771)CS(0.229)DCSYR 231.41 5.6716999999999995e-14 8655100.0 2373.9 2697.8 2854.8999999999996 2926.7 2266.8 2526.6000000000004 2395.6 2213.6 1267.27 2042.65 True False 2429.207251194693 2381.940321826807 2467.22026084318 2415.6067859631385 2061.768340236045 2501.1846979692514 2214.8979632913756 2154.888137213842 2150.4646322612793 2304.8440245959127 1.0539573286832646 1.0334496809363969 1.070449989029403 1.0480565106294535 0.8945370351460186 1.0851860999174385 0.9609752068492763 0.9349388133071777 0.9330195923510706 1.0 11.170453407309825 -6.282231670522438 0.7766603065237965 0.9587890238475568 1.0607661866571327 0.3226993336199526 0.05198688550893591 0.8581770626688623 1.1200455476530642 0.030029623557683738 0.05078536583213548 5.22117595719048e-07 6.282231670522438 0.10197716280957592 GLFQDEDS(ph)CSDCSYR ddPTM_A459_Selumetinib_30min_R2 1 GLFQDEDSCSDCSYR 15 0 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 GLFQDEDS(0.982)CS(0.018)DCSYR 149.59 0.00028233 4392300.0 15843.0 16781.0 17277.0 20009.0 21175.0 19160.0 17298.0 17746.0 14286.0 18802.0 True False 14962.509484553975 18068.048740580485 16165.4166297753 17283.739682549753 18514.80719309817 21799.116082837172 18102.391275336726 17797.63792199156 17143.5991841911 18259.13740653722 0.819453249702641 0.989534627967238 0.8853329853352045 0.9465802955380439 1.0140022927079466 1.1938743653373547 0.9914154689944787 0.9747250116875494 0.938905206883063 1.0 14.15633099105418 -6.143795045516903 3.3925717718579453 1.0249758189525462 0.9083659273500677 0.34678502632414776 0.07445999973128657 0.31184726967341736 6.67114358116934 0.024027400388385106 0.03209456101216477 7.181331163847377e-07 6.143795045516903 -0.11660989160247848 GLFQDEDSCS(ph)DCSYR ddPTM_A459_Selumetinib_30min_R1 2 GLFQDEDSCSDCSYR 15 0 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 GLFQDEDS(0.304)CS(0.695)DCS(0.001)YR;GLFQDEDS(0.152)CS(0.795)DCS(0.053)YR 205.33 3.599100000000001e-06 11886600.0 2802.6 3697.3 2995.0 3948.8 3367.9 3228.1 3486.3999999999996 3321.8 1796.68 2266.6 True False 2867.895127089702 3264.4183971718635 2588.2954503573933 3259.216208156369 3063.27403965104 3195.6282448802885 3223.4180410832555 3233.6950732729233 3048.834735684737 2557.54018855364 1.121348997730345 1.276389873278192 1.0120253288458183 1.2743558137397428 1.197742289001295 1.2494928756867376 1.2603587054114633 1.2643770321754622 1.1920965110655555 1.0 11.320541194963676 -4.692021806995667 21.87119347077352 1.2012145621602461 1.1213341088578086 0.036579180267066524 0.09858719831311591 37422.278448014695 11782219.22304835 0.023184672321716282 103.30795242066141 2.0322549638467494e-05 4.692021806995667 -0.07988045330243754 GLFQDEDSCS(ph)DCSYR ddPTM_A459_Selumetinib_30min_R2 1 GLFQDEDSCSDCSYR 15 0 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 GLFQDEDS(0.103)CS(0.711)DCS(0.186)YR 205.66 2.5661000000000003e-06 9248000.0 32295.0 29754.0 30542.0 33211.0 34281.0 26877.0 26810.0 23627.0 28743.0 28306.0 True False 30500.17318712814 32036.036125810842 28576.96097161527 28687.604507829474 29974.3143039716 30579.062784885944 28056.71812300718 23695.750658339584 34492.40314652139 27488.732232179696 1.1095518312562664 1.1654242856754173 1.0395881749017744 1.0436132254308301 1.0904218517899549 1.1124217198015611 1.0206624985841497 0.8620168605156749 1.2547833365026142 1.0 14.746552751495875 -4.8309649935627625 0.5743248035770914 1.0399964424173327 1.2001373324587168 0.07297593794168489 0.09591733791337934 9.433058430494157 2.4618671348441077 0.051318702617128745 1.0035666995040158 1.4758254878386405e-05 4.8309649935627625 0.1601408900413841 GLFQDEDSCSDCS(ph)YR ddPTM_A459_Selumetinib_30min_R2 1 GLFQDEDSCSDCSYR 15 0 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 GLFQDEDS(0.223)CS(0.066)DCS(0.668)Y(0.043)R 109.95 0.0036195 9321000.0 42562.0 43328.0 42528.0 50449.0 51104.0 39536.0 38818.0 33219.0 26706.0 43105.0 True False 40196.57442918554 46651.11827852161 39791.79478098534 43577.75917062084 44683.85864444339 44981.72512792537 40623.113916407776 33315.661790298516 32047.946227985965 41860.44664975996 0.9602519238627388 1.1144438727289385 0.9505821835566469 1.041024706096172 1.0674482051829617 1.0745639076496407 0.9704414827747836 0.7958744938639961 0.7655901642934271 1.0 15.353300084739725 -7.602479006236159 4.394320922498052 0.8371807328527786 1.0355869916670792 0.5371712061765254 0.07441662024459866 0.1443706393950908 5.232896256031734 0.035198126358295 0.01963120248138654 2.497589119513449e-08 7.602479006236159 0.19840625881430063 GLFS(ph)DEEDSEDLFSSQSASK ddPTM_A459_Selumetinib_30min_R1 2 GLFSDEEDSEDLFSSQSASK 20 0 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 GLFS(1)DEEDSEDLFSSQSASK;GLFS(1)DEEDSEDLFSSQSASK 227.4 5.9066e-24 16029300.0 5502.9 5916.0 6683.8 6824.6 5874.5 5571.4 6136.2 5203.0 3387.8 4875.9 True False 5631.106863220553 5223.351969726216 5776.176671485394 5632.811723608169 5343.152512227214 5515.356774426454 5673.3414937170355 5064.999538274136 5748.849164877855 5501.76926028796 1.0235083655481807 0.9493949532614221 1.049876212217426 1.023818240482399 0.9711698654457124 1.0024696626658935 1.0311849198525087 0.9206128608179829 1.0449091724680877 1.0 12.425679920132513 -6.2424096311083295 24.622443055130027 0.9932653408562719 1.0099331744067375 0.038701570945908315 0.03954624107327813 2845.0123307046256 3681133.5316053196 0.01135570493850517 0.014638049977296915 5.722560184771658e-07 6.2424096311083295 0.016667833550465527 GLFS(ph)DEEDSEDLFSSQSASK ddPTM_A459_Selumetinib_30min_R2 1 GLFSDEEDSEDLFSSQSASK 20 0 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 GLFS(0.996)DEEDS(0.004)EDLFSSQSASK 72.227 0.023792 0.0 4441.4 5154.6 4643.3 5318.4 5233.9 4546.6 3997.3 2569.5 3319.6 4152.3 True False 4194.564768332896 5549.9412453486775 4344.555133242789 4594.024745248265 4576.37069034033 5172.852880074502 4183.182370499684 2576.976819596377 3983.612757373707 4032.4123100289603 1.040212271423894 1.376332780143908 1.0774084590599782 1.139274556280499 1.13489651813593 1.2828184427493108 1.037389544738703 0.6390658051477552 0.9878981738712869 1.0 11.977427445132427 -7.527718550615089 24.89144376625349 0.8557346472157372 1.175039567983041 0.5166157220493421 0.1295998278792818 91.10798792826938 468562.8528241269 0.05668608396217318 0.03288004734946369 2.9667534043125917e-08 7.527718550615089 0.31930492076730377 GLFS(ph)DEEDSEDLFSSQSASNLK ddPTM_A459_Selumetinib_30min_R1 3 GLFSDEEDSEDLFSSQSASNLK 22 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 GLFS(1)DEEDSEDLFSSQSASNLK;GLFS(1)DEEDSEDLFSSQSASNLK;GLFS(1)DEEDSEDLFSSQSASNLK 264.8 9.301899999999998e-55 41428000.0 7084.700000000001 8401.599999999999 8649.4 9490.6 8217.9 7789.5 8175.9 7555.6 4315.2 6603.7 True False 7249.759725573545 7417.93676620212 7474.858987753334 7833.244870626219 7474.592395988082 7711.144702300115 7559.185280545146 7355.2009439523445 7322.579230261798 7451.349220485163 0.9729459069832065 0.9955159188900736 1.003155102059039 1.051251879202112 1.0031193244089298 1.0348655624810505 1.0144720180022595 0.9870965279323524 0.9827185672804931 1.0 12.863285963587778 -4.925092617409296 2.193323049233453 1.0113972651501086 0.9694096611373748 0.24930093983256363 0.01953772392992393 0.6807363628297375 4.841573661486755 0.0055726951132041265 0.05044985568646881 1.18824879511104e-05 4.925092617409296 -0.041987604012733826 GLFS(ph)DEEDSEDLFSSQSASNLK ddPTM_A459_Selumetinib_30min_R2 7 GLFSDEEDSEDLFSSQSASNLK 22 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 GLFS(1)DEEDSEDLFSSQSASNLK;GLFS(1)DEEDSEDLFSSQSASNLK;GLFS(0.945)DEEDS(0.055)EDLFSSQSASNLK;GLFS(0.953)DEEDS(0.047)EDLFSSQSASNLK;GLFS(1)DEEDSEDLFSSQSASNLK;GLFS(1)DEEDSEDLFSSQSASNLK;GLFS(0.782)DEEDS(0.218)EDLFSSQSASNLK 166.6 8.8653e-13 6996700.0 54823.6 51354.0 58797.69999999999 57814.200000000004 55028.3 42944.90000000001 44062.299999999996 47178.3 40022.869999999995 57574.1 True False 51776.7237882594 55292.68667086408 55014.719996095315 49939.80622494214 48115.15299475627 48860.17016001218 46111.28425779104 47315.58104221197 48028.56233242241 55911.78613752339 0.9260431004816554 0.988927209995822 0.9839556879971316 0.8931892481865581 0.8605547473731184 0.8738796152895795 0.8247149204708547 0.8462541498107792 0.8590060459576265 1.0 15.770864813062275 -5.879941447542521 4.264711387359725 0.8676257458659733 0.9683258260260807 0.4040708011006263 0.047484852308541936 0.18050874235672226 5.812272611478884 0.01292856220272096 0.01988293383838103 1.3184344805686737e-06 5.879941447542521 0.10070008016010745 GLGACTLLGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 GLGACTLLGSPR 12 0 K7ER53;O95644-8;O95644-11;O95644-3;O95644-10;O95644-2;O95644-5;O95644-4;O95644-6;O95644 K7ER53 NFATC1 Nuclear factor of activated T-cells, cytoplasmic 1 1 GLGACTLLGS(1)PR 106.79 0.008755500000000001 16664000.0 1059.1 1658.9 1089.5 1157.3 1293.1 1266.5 1302.7 1408.8 887.36 1320.8 True False 1083.7749693501414 1464.675216798313 941.5518841951193 955.1992802115486 1176.1393333153471 1253.7601598899932 1204.4362901902127 1371.4340475726706 1505.78510978984 1490.3375456814836 0.7272010105969422 0.9827808613172688 0.6317708944013605 0.6409281460964379 0.7891764766467964 0.8412591922702242 0.8081634215552576 0.9202170686410224 1.0103651445627995 1.0 10.541423407516765 -7.804937921587218 1.1858478518423727 1.0165662042213055 0.7606329423197686 0.5156430111882289 0.09350844263580022 0.4254405431023986 1.0815774602015855 0.08519549017717437 0.032541140398440326 1.5669750388099294e-08 7.804937921587218 -0.25593326190153687 GLGACTLLGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 GLGACTLLGSPR 12 0 K7ER53;O95644-8;O95644-11;O95644-3;O95644-10;O95644-2;O95644-5;O95644-4;O95644-6;O95644 K7ER53 NFATC1 Nuclear factor of activated T-cells, cytoplasmic 1 1 GLGACTLLGS(1)PR;GLGACTLLGS(1)PR;GLGACTLLGS(1)PR 142.12 0.00093539 25529800.0 76551.0 62978.0 66922.0 68547.0 72782.0 39994.0 63097.0 65330.0 62714.0 49889.0 True False 72296.60187793289 67808.21009381315 62616.3113791643 59210.78034982947 63638.47448066446 45502.81047061533 66031.13552433357 65520.09948403632 75258.55237556774 48448.57494281112 1.4922338162324085 1.3995914260399653 1.2924283418671616 1.222136676253576 1.3135262400552246 0.9391981193322407 1.3629118214989187 1.3523638117607482 1.5533697836190892 1.0 15.564166610655743 -5.087607752952828 1.9642942365720273 1.2577312258361855 1.5016489650928915 0.18519519298908105 0.1673531720415794 0.8123103150632922 5.07643405658324 0.047060321354099904 0.2864741280207711 8.173202271831342e-06 5.087607752952828 0.243917739256706 GLGHPPS(ph)SPLLK ddPTM_A459_Selumetinib_30min_R2 2 GLGHPPSSPLLK 12 0 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 GLGHPPS(0.865)S(0.135)PLLK;GLGHPPS(0.879)S(0.121)PLLK 111.72 0.004419 8210400.0 88504.0 73308.0 90791.0 97183.0 90362.0 83711.0 80458.0 87545.0 77244.0 88996.0 True False 83585.3019895832 78930.48787762804 84949.60590576666 83946.50774997403 79009.91771347042 95241.43039720164 84199.45642450242 87799.741456145 92694.95837768842 86426.45424062271 0.9671263587520393 0.9132676860475508 0.9829120800126276 0.9713057013337122 0.9141867314548892 1.101993958146621 0.9742324519073752 1.0158896628073955 1.0725299237616919 1.0 16.399185353513936 -6.744933248737731 24.999997499241427 1.030253776695975 0.9507711756149692 0.5241681893971735 0.03957408844218973 202.72063266479947 307037.93319036823 0.01270865195068058 0.012673716577601234 1.7991474236677117e-07 6.744933248737731 -0.0794826010810058 GLGKPGGQGDAIQLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 GLGKPGGQGDAIQLSPK 17 1 Q5VV41 Q5VV41 ARHGEF16 Rho guanine nucleotide exchange factor 16 1 GLGKPGGQGDAIQLS(1)PK;GLGKPGGQGDAIQLS(1)PK 97.589 0.0030416 22241100.0 165080.0 134070.0 140556.0 131828.0 118163.0 92867.0 136025.0 125115.0 80496.0 106683.0 True False 155905.51446759896 144352.7378970041 131512.77998580172 113872.79898401581 103318.30754937702 105658.58628730883 142350.4320284242 125479.0639360968 96597.44924616051 103602.78459427788 1.5048390357280979 1.3933287455767562 1.2693942590522354 1.0991287486138202 0.9972541563818491 1.0198431123360414 1.374001988323839 1.2111553220069258 0.9323827503715157 1.0 16.660703254163664 -5.374043935208813 1.857015167771274 1.1040603223665444 1.4855596433830465 0.5870459202057012 0.12140643832533121 0.30402437361044055 1.9308876351742343 0.03777725163571937 0.1304423907652554 4.226258573453167e-06 5.374043935208813 0.3814993210165021 GLGLGANLTEAQALT(ph)PTGPSR ddPTM_A459_Selumetinib_30min_R2 2 GLGLGANLTEAQALTPTGPSR 21 0 Q92917 Q92917 GPKOW G patch domain and KOW motifs-containing protein 1 GLGLGANLT(0.01)EAQALT(0.752)PT(0.231)GPS(0.008)R;GLGLGANLT(0.265)EAQALT(0.652)PT(0.083)GPSR 224.8 8.0697e-21 11872500.0 23012.7 25898.0 27004.0 33382.0 26294.0 23846.0 25018.0 25219.0 20838.0 25142.0 True False 21733.746261137134 27884.29332480503 25266.592039732128 28835.314012837996 22990.712648657533 27130.57004756444 26181.386572226525 25292.383114769797 25006.182262366958 24416.085133238954 0.8901405013349087 1.1420460394301548 1.0348338770057504 1.180996619871009 0.9416215795119021 1.111176091478732 1.0723007570359577 1.0358901919267103 1.024168376130237 1.0 14.575544277187067 -8.28414149347435 1.9458574322027269 1.0029572633241732 1.0584399735522068 0.03666159109358258 0.08230735547968494 1.094274651521399 7.758382291833836 0.07224717028909568 0.021071742731007516 5.198266090349428e-09 8.28414149347435 0.05548271022803353 GLGPPS(ph)PPAPPR ddPTM_A459_Selumetinib_30min_R1 6 GLGPPSPPAPPR 12 0 Q13425;Q13425-2;A0A140TA73 Q13425 SNTB2 Beta-2-syntrophin 1 GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR 161.25 0.00045232 620729000.0 11064.599999999999 13752.5 12890.800000000001 13863.1 13626.8 11664.3 12476.0 12649.599999999999 6730.619999999999 10543.1 True False 11322.383652036224 12142.350906636206 11140.300164095861 11442.169827616623 12394.258346006935 11546.967732337023 11534.925275514772 12314.09151630838 11421.370554964938 11896.409583490642 0.9517479683743381 1.0206735756212422 0.9364422169488785 0.9618170715554049 1.0418486568592247 0.9706262760456265 0.9696139994643826 1.035109915297249 0.9600687060081603 1.0 13.538238603698224 GLGPPS(ph)PPAPPR ddPTM_A459_Selumetinib_30min_R2 4 GLGPPSPPAPPR 12 0 Q13425;Q13425-2;A0A140TA73 Q13425 SNTB2 Beta-2-syntrophin 1 GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR;GLGPPS(1)PPAPPR 143.37 0.00083101 534640000.0 436620.0 407274.0 439619.0 501254.0 497417.0 327538.0 334755.0 293433.0 304785.0 430635.0 True False 412354.4083283446 438510.6062076848 411334.39216097695 432982.340488619 434927.02949559916 372653.3864060713 350321.77080444887 294286.8414495517 365750.5164044296 418201.4486258995 0.9860186034343813 1.0485630971593136 0.9835795488334966 1.0353439518473349 1.0399940768370257 0.8910858334673704 0.8376866506692278 0.703696370293554 0.8745797452548051 1.0 18.673838533786068 -6.911599619473297 3.4324455423374114 0.8318748497385162 1.0194066589492046 0.5434037339320643 0.0713425982302042 0.16195760743316848 3.782165225915677 0.02597632792396075 0.022405759380011 1.2257457060417327e-07 6.911599619473297 0.18753180921068835 GLGPS(ph)PAGDGPSGSGK ddPTM_A459_Selumetinib_30min_R1 1 GLGPSPAGDGPSGSGK 16 0 Q92934;F5GYS3;A8MXU7 Q92934 BAD Bcl2-associated agonist of cell death 1 GLGPS(1)PAGDGPSGSGK 189.04 9.4208e-07 9555200.0 2759.2 2182.2 3167.5 2755.2 3041.3 2376.0 2645.8 3002.9 1591.1 2375.0 True False 2823.483991531401 1926.7070095227423 2737.370897832068 2274.0560415094274 2766.2149519851264 2352.0995972353926 2446.2251758542 2923.2533372061107 2699.9804906538625 2679.854384459056 1.053596049063441 0.7189595900046111 1.0214625517366018 0.8485744802766434 1.0322258433245068 0.8776967923614168 0.9128201853206233 1.0908254396800692 1.00751014917509 1.0 11.387938895596541 -7.746469047532284 24.931453973618346 1.036875840487266 0.9190355834287001 0.21018875675467785 0.09658430274808762 301.4714581872952 502069.7585601149 0.04232220868208345 0.024307844495079743 1.792796321644596e-08 7.746469047532284 -0.11784025705856593 GLGPS(ph)PAGDGPSGSGK ddPTM_A459_Selumetinib_30min_R2 1 GLGPSPAGDGPSGSGK 16 0 Q92934;F5GYS3;A8MXU7 Q92934 BAD Bcl2-associated agonist of cell death 1 GLGPS(0.999)PAGDGPS(0.001)GSGK 98.281 0.0071704 8363600.0 37543.0 31252.0 41560.0 44360.0 40695.0 32840.0 44225.0 42450.0 33952.0 35041.0 True False 35456.51035653665 33648.92790898165 38886.074847106625 38318.09147473174 35582.530282084044 37363.41190816139 46281.550130175 42573.522472024204 40743.34869814201 34029.275282548166 1.0419413890580398 0.9888229364155288 1.1427241551350127 1.1260331334291764 1.0456446687929455 1.0979784787636406 1.360051007430957 1.251085194102207 1.1973028623103572 1.0 15.054488806273847 -7.029031197973367 23.51549753423282 1.2238880592595571 1.0718350943652353 0.30643659702055637 0.09303007316245775 356.9591209549914 289138.30470133934 0.03455596370547216 0.026830872302144728 9.353384807698681e-08 7.029031197973367 -0.15205296489432185 GLGS(ph)SPDLELLLR ddPTM_A459_Selumetinib_30min_R1 1 GLGSSPDLELLLR 13 0 Q9NQQ7-2;Q9NQQ7;Q9NQQ7-3 Q9NQQ7-2 SLC35C2 Solute carrier family 35 member C2 1 GLGS(0.5)S(0.5)PDLELLLR 112.08 0.005031 17227000.0 473.26 761.36 759.01 932.95 730.42 624.93 646.44 562.28 361.07 525.62 True False 484.28603719634395 672.2196172533387 655.9406109434948 770.027796140469 664.3536399661248 618.6437715910412 597.67851034817 547.3665078571554 612.7094184905984 593.088446972366 0.81654943654451 1.1334222082472292 1.1059743522099956 1.2983355182036571 1.1201594692285066 1.043088555761171 1.0077392560911203 0.922908734188611 1.0330827073405235 1.0 9.212103458952969 -7.0544508875443 2.745908043333944 0.9841706199757584 1.1079639733279212 0.15045024260529605 0.11360670153543169 0.49140254077753037 7.333633427462617 0.048862976237578265 0.03788561228597076 8.821635564986476e-08 7.0544508875443 0.1237933533521628 GLGS(ph)SPDLELLLR ddPTM_A459_Selumetinib_30min_R2 2 GLGSSPDLELLLR 13 0 Q9NQQ7-2;Q9NQQ7;Q9NQQ7-3 Q9NQQ7-2 SLC35C2 Solute carrier family 35 member C2 1 GLGS(0.829)S(0.171)PDLELLLR;GLGS(0.5)S(0.5)PDLELLLR 179.5 0.00010967 18257000.0 23539.0 8691.7 22260.0 22794.6 20047.6 12751.5 21840.0 24021.0 21152.1 14541.599999999999 True False 22230.796614082938 9358.325441779602 20827.815834855486 19689.936157121727 17529.04126018204 14507.903378408033 22855.603275138987 24090.897133109385 25383.111039054227 14121.746224385783 1.574224338891903 0.6626889687069587 1.4748753804178618 1.3942989658828917 1.2412800075611368 1.0273448586234628 1.6184686307187253 1.7059432134185095 1.7974484625153537 1.0 13.785630875629868 -7.278889562397764 24.305265933607444 1.5892937344633433 1.2226036775575042 0.17309691580720543 0.31205616276716164 839.2249030097774 1168897.9141982642 0.1252346487860452 0.08467410640982895 5.261510453698493e-08 7.278889562397764 -0.3666900569058391 GLGSS(ph)PDLELLLR ddPTM_A459_Selumetinib_30min_R1 1 GLGSSPDLELLLR 13 0 Q9NQQ7-2;Q9NQQ7;Q9NQQ7-3 Q9NQQ7-2 SLC35C2 Solute carrier family 35 member C2 1 GLGS(0.262)S(0.738)PDLELLLR 151.16 0.00047295 12088000.0 290.25 267.0 332.28 220.45 201.39 424.41 377.04 259.13 201.53 136.39 True False 297.0122602718141 235.73951587506767 287.1582010833908 181.9525458590132 183.17431005829235 420.1408207334483 348.5995692433546 252.2570306271336 341.98169083116915 153.8969850511034 1.9299420334530109 1.5318007418844979 1.865911804497251 1.1823009125136117 1.1902397567922922 2.730013330631106 2.265148788506791 1.6391291261707857 2.222146786810735 1.0 7.26582115831916 -6.73009208880447 24.99994084919876 2.0296011322578846 1.5378112573890337 0.16274347040853188 0.48003429341201365 328.94807751675825 262340.3136928689 0.1560212952428675 0.15600754308226242 1.8616923372665247e-07 6.73009208880447 -0.49178987486885095 GLGT(ph)DEDTLIEILASR ddPTM_A459_Selumetinib_30min_R1 1 GLGTDEDTLIEILASR 16 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 1 GLGT(0.999)DEDT(0.001)LIEILASR 150.39 0.0014979 0.0 342.78 288.16 389.28 456.38 675.3 326.5 590.14 558.89 217.68 323.8 True False 350.76610706622705 254.42209323805048 336.4179141619787 376.68180031361504 614.2192342338988 323.215706438281 545.6252646755601 544.0664216694279 369.3870612818383 365.3628840790915 0.9600485499514926 0.6963545130735687 0.9207774758236061 1.03097992907258 1.6811210470435645 0.88464296873766 1.4933790170033978 1.4891124560743607 1.011014192678301 1.0 8.513186272906072 -6.017879820942871 9.360417228381454 1.2844882867111143 0.8643424028948743 0.3522547798213477 0.24474547023882445 0.29420126871031543 145.97366235661005 0.06848094105403521 0.09254247995224206 9.596661559990087e-07 6.017879820942871 -0.42014588381623996 GLGTDEDS(ph)LIEIICSR ddPTM_A459_Selumetinib_30min_R1 9 GLGTDEDSLIEIICSR 16 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 GLGT(0.001)DEDS(0.999)LIEIICSR;GLGTDEDS(1)LIEIICSR;GLGT(0.001)DEDS(0.999)LIEIICSR;GLGTDEDS(1)LIEIICSR;GLGTDEDS(0.999)LIEIICS(0.001)R;GLGTDEDS(1)LIEIICSR;GLGT(0.002)DEDS(0.927)LIEIICS(0.071)R;GLGTDEDS(0.999)LIEIICSR;GLGT(0.017)DEDS(0.983)LIEIICSR 319.74 2.0284999999999994e-117 140607990.0 19471.900000000005 22738.26 22404.460000000003 25625.539999999997 21682.15 19592.28 21525.54 19299.91 11521.93 16864.3 True False 19925.55738427817 20076.05394846971 19362.05739088956 21150.52048996134 19721.003360794504 19395.199451566925 19901.851187488322 18788.013691857068 19551.87368152818 19028.99717719279 1.0471154732294539 1.0550242748751821 1.0175027727733315 1.1114889709117886 1.036365877673844 1.0192444336905493 1.0458696799504335 0.9873359860694839 1.0274778801776316 1.0 14.21591191354119 -7.150856264140091 1.2085143645631131 1.0079234156744559 1.0545822974921375 0.348020928373444 0.02632034484337965 0.5482453998502964 1.5923194599625476 0.016216282250180365 0.010213464421998499 7.065513586684369e-08 7.150856264140091 0.04665888181768163 GLGTDEDS(ph)LIEIICSR ddPTM_A459_Selumetinib_30min_R2 5 GLGTDEDSLIEIICSR 16 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 GLGT(0.008)DEDS(0.992)LIEIICSR;GLGT(0.002)DEDS(0.998)LIEIICSR;GLGTDEDS(1)LIEIICSR;GLGTDEDS(1)LIEIICSR;GLGT(0.138)DEDS(0.862)LIEIICSR 257.16 6.5587e-39 25293200.0 54426.0 54703.5 64403.7 67152.4 68494.8 41263.9 42870.2 47930.9 51145.9 52443.8 True False 51401.22080454048 58899.08255052406 60260.0360594466 58006.12727564865 59889.870872718784 46947.62766861085 44863.74924568971 48070.37098361236 61376.5091358477 50929.6112286436 1.0092600270161034 1.1564801130348765 1.183202357247829 1.1389469873476104 1.1759341850038667 0.9218139808262816 0.8808971473251233 0.9438589815226558 1.205124242168348 1.0 15.636217084009544 -6.757114851897416 24.9982366575181 0.9799899440953321 1.1372278155553304 0.3681261246166171 0.09271265364461197 116.02153008853752 670671.1488569138 0.03202783795252202 0.030956702984012777 1.7493839918859715e-07 6.757114851897416 0.15723787145999824 GLGTDEDSLIEIICSR ddPTM_A459_Selumetinib_30min_R1 3 GLGTDEDSLIEIICSR 16 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;; 314.35 3.228299999999999e-101 64458000.0 6110.9 6887.1 7115.7 7795.8 7233.1 6350.6 6147.2 6159.8 4015.4 5257.4 False True 6253.272080258497 6080.755130274077 6149.427023742271 6434.409875290066 6578.867382107524 6286.718729883448 5683.511754860889 5996.422094149723 6813.84052678746 5932.238501412646 1.0541167686985955 1.0250355121133556 1.0366115627815546 1.0846512448475965 1.109002509009187 1.0597548848358658 0.958072025173545 1.010819455880237 1.148612033242574 1.0 12.534360886144505 -9.634322783215787 15.120108661227194 0.9999920443143929 1.0512933877761435 0.09219694055909544 0.05022645733179087 0.0 0.0 0.05078730907868843 0.012317731751313128 2.3210110965478389e-10 9.634322783215787 0.051301343461750526 GLGTDEDSLIEIICSR ddPTM_A459_Selumetinib_30min_R2 3 GLGTDEDSLIEIICSR 16 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;; 331.92 1.464699999999999e-133 28603600.0 29254.3 26849.7 28286.1 29534.9 30924.2 19916.4 24470.4 21873.1 20037.2 22184.6 False True 27628.4631202416 28908.98565460722 26466.203121577077 25512.195669455687 27039.225530144337 22659.703316921623 25608.322087177712 21936.747099713364 24045.199886145456 21544.072955486947 1.2824159655106 1.3418533122468164 1.2284679492248256 1.1841862827965461 1.2550656315549589 1.0517836327299728 1.188648132601856 1.018226550988652 1.1160935045024303 1.0 14.395003399961244 -5.987359465052534 0.2941178402979618 0.9973473336359896 1.4370231522289545 0.7245541027744091 0.05798834283006124 1.929299572708667 0.24034770768838856 0.07112164371294782 0.2931087734713758 1.029533623866499e-06 5.987359465052534 0.4396758185929649 GLGTDEDTLIEILAS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 GLGTDEDTLIEILASR 16 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 1 GLGTDEDTLIEILAS(1)R;GLGTDEDTLIEILAS(1)R 177.66 1.1506999999999998e-06 12649200.0 1724.17 1628.76 2647.01 2385.82 2742.67 1166.29 2300.67 2501.09 1167.29 2218.3 True False 1764.339806349194 1438.0640220100179 2287.560580985152 1969.181324388075 2494.5959827577162 1154.558181506593 2127.1286096199574 2434.7529685147133 1980.8058745115636 2503.040413071799 0.7048786736063716 0.574526889178424 0.9139127634690467 0.7867157534110456 0.9966263308135247 0.4612623014303185 0.8498179248370535 0.9727182013520583 0.7913599253799762 1.0 11.289465869043344 -7.249217431730173 0.04374564442989533 1.632855671138086 2.313250662157375e-09 0.20740063899979688 0.15383146789306143 141.67983123225923 3.6955683145519225 63.36724598929864 72.80556264528137 5.633555384088467e-08 7.249217431730173 -1.6328556688248352 GLGTDEDTLIEILASR ddPTM_A459_Selumetinib_30min_R1 1 GLGTDEDTLIEILASR 16 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 0 160.18 0.00077574 92489000.0 631.25 672.41 762.5 690.65 673.29 588.75 656.09 556.2 456.0 504.01 False True 645.9568968013183 593.6839246050718 658.9566881126918 570.0409426061577 612.391038379004 582.8277095422294 606.6006030789104 541.4477692077792 773.7986950777209 568.7045929731408 1.1358390714312834 1.0439232106449872 1.1586976723147608 1.0023498133293254 1.0768174654216771 1.0248338359555953 1.0666356673992243 0.9520720878604738 1.360633806441346 1.0 9.151535645608417 -10.82688499228047 3.166167277456053 0.9994909290532845 1.082080517940714 0.05551900905579876 0.10705638246261313 65796479.77754234 83469968.42684469 314969.9174888996 0.024702153727765082 1.4897555351817497e-11 10.82688499228047 0.08258958888742951 GLGTDEDTLIEILASR ddPTM_A459_Selumetinib_30min_R2 1 GLGTDEDTLIEILASR 16 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 0 166.6 0.00022371 28047000.0 24626.0 46019.0 42750.0 29631.0 33800.0 18203.0 20420.0 24429.0 31680.0 27357.0 False True 23257.385505688708 49548.50932559282 39999.511542680666 25595.20668367393 29553.741824166136 20710.29801961821 21369.57046146237 24500.08434556133 38016.88521315793 26567.13232797781 0.875419492723962 1.8650303959759087 1.5056013968266058 0.9634162380679547 1.1124174585091795 0.779545860047839 0.804361200811956 0.9221952916521714 1.4309743612456962 1.0 14.697354890423338 -5.763124832467384 24.97176562282181 0.9857187490341387 1.4603184954589419 0.30443317992075014 0.2832646651380831 46.02882409247828 681983.9906759025 0.07749146137085104 0.1220845089649985 1.725341892958524e-06 5.763124832467384 0.4745997464248032 GLHSENREDEGWQVYR ddPTM_A459_Selumetinib_30min_R1 2 GLHSENREDEGWQVYR 16 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 0 ; 83.87700000000002 0.014191 13163600.0 7408.3 7694.299999999999 16449.5 16373.4 11132.8 9512.3 7668.299999999999 8418.5 5494.1 6103.5 False True 7580.898975957553 6793.447779016976 14215.748250635721 13514.093056783706 10125.840205655473 9416.614898477359 7089.873957216248 8195.214032858126 9323.086426812515 6886.9436781245695 1.1007638990917317 0.9864241812511738 2.0641592141649268 1.9622772725308275 1.4702951960851391 1.3673140566530175 1.0294659414358591 1.1899638527448828 1.3537335082942552 1.0 12.749648163285736 -6.958146671154797 3.0861859622157928 1.1604553300977258 1.5422641355817532 0.22591043833429658 0.32264363682830766 0.44249796163368016 8.636529140037595 0.1402311722540982 0.11690095710046261 1.1011673573972938e-07 6.958146671154797 0.3818088054840274 GLHVVEVTYDDVPIPNS(ph)PFK ddPTM_A459_Selumetinib_30min_R1 1 GLHVVEVTYDDVPIPNSPFK 20 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 GLHVVEVTYDDVPIPNS(1)PFK 155.76 2.2474e-07 0.0 3422.4 3835.5 4048.5 4038.5 3519.4 3455.2 3382.5 3507.4 1798.0 3357.3 True False 3502.135261168842 3386.4378769244263 3498.735936818667 3333.2517870339057 3201.070891400537 3420.443825070591 3127.355301733627 3414.372358359159 3051.074679275752 3788.242157871321 0.9244750243571421 0.8939338447221453 0.9235776888098061 0.8798940638227092 0.845001654593083 0.9029105538999117 0.8255426056213213 0.9013078404358802 0.805406452947085 1.0 11.887312840598709 -5.860623467091828 5.839155795525486 0.8726326681015627 0.911794213612239 0.07344993839243008 0.05108306785103091 0.44965973279108057 22.14074167700319 0.013266895151792675 0.01998886366484919 1.3784040259759066e-06 5.860623467091828 0.0391615455106763 GLIVYCVTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 GLIVYCVTSPK 11 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 GLIVYCVT(0.024)S(0.976)PK 139.15 0.001192 43822000.0 6199.5 6106.5 8841.1 9111.4 5301.4 7083.0 5778.6 5845.8 3793.1 5532.4 True False 6343.93628787291 5391.54814116517 7640.527180686064 7520.265032160642 4821.889306038192 7011.751450849445 5342.7155496224495 5690.750394165469 6436.61366293707 6242.537430139485 1.0162432118138152 0.8636789449005674 1.223945753820709 1.2046808074953916 0.7724245725396397 1.1232213710079064 0.8558563900357856 0.9116085338455573 1.0310893182411 1.0 12.607916851214409 -6.248524769581808 24.973035176961737 0.9486643336501056 1.072376472927077 0.18943806933277496 0.129664798485637 1463.050998911363 2829107.4781092736 0.03912141418475412 0.050170295741837324 5.642547586820495e-07 6.248524769581808 0.12371213927697144 GLIVYCVTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 GLIVYCVTSPK 11 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 GLIVYCVT(0.015)S(0.985)PK;GLIVYCVT(0.054)S(0.946)PK 161.67 0.00061528 32869000.0 300937.0 268454.0 267461.0 262662.0 280498.0 200416.0 245359.0 208640.0 147394.0 255054.0 True False 284212.12628626043 289043.5585843393 250252.8504495189 226886.98248277637 245259.33355606374 228021.48480469178 256768.67966963514 209247.10785778874 176876.91853245537 247689.92831012388 1.1474512840522462 1.1669572540004047 1.010347300582146 0.9160121448244724 0.9901869455466236 0.9205924777013705 1.0366536961008121 0.8447945755622238 0.7141062203829054 1.0 17.91817568063734 -4.725092879127359 0.4920773337156742 0.8827643726901108 1.4152143910719848 0.5324410122178509 0.08755390396016144 3.9146892197081717 0.7014478594440382 0.058759670055455654 1.229324930057209 1.8832462914241114e-05 4.725092879127359 0.532450018381874 GLLAQGLRPES(ph)PPPAGPLLNGAPAGES(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 1 GLLAQGLRPESPPPAGPLLNGAPAGESPQPK 31 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 2 GLLAQGLRPES(1)PPPAGPLLNGAPAGES(1)PQPK 93.175 4.6013e-07 142680000.0 2080.8 3071.7 3368.5 3458.2 3126.3 2696.0 2787.5 2747.5 1725.2 2599.6 True False 2129.278591468013 2712.063936005411 2911.0762018460377 2854.290288453796 2843.5267169930953 2668.880687772145 2577.2366307708758 2674.627374862231 2927.538396377377 2933.28398224832 0.7259026416651113 0.9245828063079842 0.9924290383963231 0.9730698785823061 0.9694004174848331 0.9098609967271175 0.8786181789311313 0.9118201275596124 0.9980412445894382 1.0 11.518301035248406 -4.766825275511429 4.39068148376264 0.9485888611093762 0.7071835218129798 0.7444487477737354 0.039762726991167056 0.1122417878479831 4.612357239047719 0.010719707348496105 0.08589168824201847 1.7107034234464612e-05 4.766825275511429 -0.2414053392963964 GLLAQGLRPES(ph)PPPAGPLLNGAPAGES(ph)PQPK ddPTM_A459_Selumetinib_30min_R2 1 GLLAQGLRPESPPPAGPLLNGAPAGESPQPK 31 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 2 GLLAQGLRPES(1)PPPAGPLLNGAPAGES(1)PQPK 48.84 0.038496 8943600.0 44117.0 37698.0 55498.0 58380.0 44528.0 39120.0 49616.0 47279.0 37598.0 48479.0 True False 41665.153754343744 40589.31538182488 51927.319101653615 50428.54328888273 38933.99455462927 44508.424903997395 51923.24231223882 47416.574062540196 45118.650575893684 47079.28530643113 0.8849997081126505 0.8621480788766412 1.1029759428943633 1.0711407991997297 0.8269877994369386 0.9453929602860274 1.1028893487715286 1.0071642709508803 0.9583546199188029 1.0 15.522804799061452 GLLAQGLRPES(ph)PPPAGPLLNGAPAGESPQPK ddPTM_A459_Selumetinib_30min_R2 4 GLLAQGLRPESPPPAGPLLNGAPAGESPQPK 31 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 GLLAQGLRPES(1)PPPAGPLLNGAPAGESPQPK;GLLAQGLRPES(1)PPPAGPLLNGAPAGESPQPK;GLLAQGLRPES(1)PPPAGPLLNGAPAGESPQPK;GLLAQGLRPES(0.99)PPPAGPLLNGAPAGES(0.01)PQPK 92.545 1.7785999999999995e-07 392551300.0 479984.0 469735.0 510358.0 500236.0 572045.0 357492.0 399105.0 442629.0 345671.0 460202.0 True False 453308.4108081907 505762.1640639149 477522.12191577686 432102.99384476675 500179.5929528143 406733.27801073156 417664.1733115546 443916.9771088239 414814.8588547197 446914.7725116063 1.0143061690725794 1.1316747513661127 1.0684858753541777 0.9668577107362123 1.119183396292466 0.9100913709451589 0.9345499388268889 0.9932922436509871 0.9281744179623131 1.0 18.769640207415428 -6.767391073367636 24.99999530267229 0.9516353778176162 1.059363448680915 0.5221561258636562 0.05110844103740302 117.95679459849018 495472.6772779285 0.017576989919178446 0.015898522692616594 1.708476174087719e-07 6.767391073367636 0.10772807086329872 GLLAQGLRPESPPPAGPLLNGAPAGES(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 2 GLLAQGLRPESPPPAGPLLNGAPAGESPQPK 31 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 GLLAQGLRPESPPPAGPLLNGAPAGES(1)PQPK;GLLAQGLRPESPPPAGPLLNGAPAGES(1)PQPK 120.27 2.4015e-16 1712880000.0 3956.6000000000004 4320.3 4990.4 5054.0 4310.6 4224.5 3919.3 3785.0 1905.56 3480.0 True False 4048.7810817965897 3814.4772675470213 4312.731090305023 4171.413775329795 3920.706991098243 4182.005365539105 3623.664045553466 3684.609504587278 3233.5961434041706 3926.6918980705327 1.031092122044525 0.971422603698892 1.0983115564590589 1.0623226582608916 0.9984758399366066 1.0650199898785098 0.9228287167969644 0.9383495319298651 0.8234911796856458 1.0 11.93909868822696 -7.2730295406121614 22.336599839962403 0.9160297547982823 1.036839404461507 0.5448753187956737 0.05212034982835686 135.29872503551132 260744.9573555716 0.021162696464434097 0.014444280612224459 5.332986194027493e-08 7.2730295406121614 0.12080964966322472 GLLASDLNT(ph)DGDMRVTPEPGAGPTQGLLR ddPTM_A459_Selumetinib_30min_R1 1 GLLASDLNTDGDMRVTPEPGAGPTQGLLR 29 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9;V9GYX5;C9JVY3;V9GY85;H7C3H1 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 GLLAS(0.001)DLNT(0.59)DGDMRVT(0.406)PEPGAGPT(0.003)QGLLR 74.278 9.3971e-05 12646000.0 917.25 822.38 1027.9 1055.0 1032.4 827.4 1037.3 930.27 471.36 718.91 True False 938.6201403421933 726.0953672859106 888.31682585054 870.7640548027167 939.0196022850243 819.0771072190918 959.0556258649783 905.5962176571745 799.8634932277077 811.1891012764038 1.1570916557745625 0.8951000033696231 1.0950798333616365 1.0734415112734772 1.1575840957521244 1.0097240038485185 1.1822836677118898 1.1163811449540204 0.9860382640362461 1.0 9.663894458930438 GLLASDLNT(ph)DGDMRVTPEPGAGPTQGLLR ddPTM_A459_Selumetinib_30min_R2 1 GLLASDLNTDGDMRVTPEPGAGPTQGLLR 29 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9;V9GYX5;C9JVY3;V9GY85;H7C3H1 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 GLLAS(0.029)DLNT(0.761)DGDMRVT(0.204)PEPGAGPT(0.006)QGLLR 51.81100000000001 0.024347 6285000.0 6019.8 4731.8 6144.7 6708.0 7173.4 5473.9 4337.6 4361.4 5121.8 6784.1 True False 5685.24361516872 5094.713844864948 5749.35669184351 5794.358828054564 6272.213360990337 6227.880037883211 4539.306994791345 4374.090951931361 6146.303115048997 6588.225405791355 0.8629400582091693 0.7733059406841878 0.8726715219533259 0.8795022135947344 0.9520338140642199 0.9453046388498815 0.6890029886957243 0.6639255159798164 0.932922408763688 1.0 12.685674200117118 -9.58789849954837 12.35191372371833 0.9999998890247983 0.8379580569472386 0.19400989294983728 0.09683215939239159 0.0 0.0 0.10079092571693517 0.02444539016674748 2.5828637700423415e-10 9.58789849954837 -0.16204183207755973 GLLASDLNTDGDMRVT(ph)PEPGAGPTQGLLR ddPTM_A459_Selumetinib_30min_R2 1 GLLASDLNTDGDMRVTPEPGAGPTQGLLR 29 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9;V9GYX5;C9JVY3;V9GY85;H7C3H1 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 GLLAS(0.001)DLNT(0.011)DGDMRVT(0.978)PEPGAGPT(0.01)QGLLR 61.904 0.0031606 6378500.0 8146.7 10637.0 9341.8 13705.0 13753.0 7590.0 6526.8 10474.0 6581.8 9713.3 True False 7693.939027824021 11452.823696654224 8740.758758582791 11838.35535755632 12025.225186620024 8635.453604839979 6830.30913260885 10504.477605935957 7898.343910857408 9432.851790815756 0.8156535476699828 1.2141422287377825 0.9266295021292694 1.2550133957455656 1.2748239295276873 0.9154658417561315 0.7240980017579777 1.1136057089504559 0.8373230159883979 1.0 13.203478284881813 -6.861450395110394 13.768389440030596 0.9127821400229422 1.1030107479186004 0.22982013138592228 0.16367458051066633 1.005477822380332 132.7310618803864 0.056761919310955304 0.050061540150305804 1.3757819423985176e-07 6.861450395110394 0.1902286078956582 GLLEFEHQR ddPTM_A459_Selumetinib_30min_R1 1 GLLEFEHQR 9 0 F5H6X6;Q14697;Q14697-2;E9PKU7;E9PNH1 F5H6X6 GANAB Neutral alpha-glucosidase AB 0 125.82 0.0059775 0.0 5461.8 6335.5 6994.0 7613.4 7142.6 5281.4 5268.6 4736.5 2717.6 3574.2 False True 5589.049313187235 5593.736714705956 6044.253215292024 6283.862611218016 6496.553091128449 5228.273911127525 4871.185260225803 4610.8726336796935 4611.568714349155 4032.9833856562373 1.3858349461754103 1.3869972126839687 1.4987052108345142 1.5581176539351207 1.6108554065048164 1.2963787378154035 1.2078366793056292 1.1432907584193837 1.1434633553787308 1.0 11.97763174706823 -7.139212857873363 2.234292733159558 1.1217765560317043 1.4854600064015344 0.8137707771051048 0.08186654555472116 0.14486092268116912 1.4174056201389928 0.04021641809545066 0.028711119052217973 7.257501631377996e-08 7.139212857873363 0.3636834503698301 GLLEFEHQR ddPTM_A459_Selumetinib_30min_R2 3 GLLEFEHQR 9 0 F5H6X6;Q14697;Q14697-2;E9PKU7;E9PNH1 F5H6X6 GANAB Neutral alpha-glucosidase AB 0 ;; 171.99 0.00073881 12076800.0 131530.0 108373.0 137678.0 147136.0 149753.0 117057.0 109991.0 125544.0 109305.0 118107.0 False True 124220.08915630786 116684.86062588239 128819.94737247244 127095.822976243 130939.68933119376 133180.53921235225 115105.79944303162 125909.31225507193 131169.05423687588 114696.94403116124 1.0830287607537246 1.0173319054968113 1.1231332138847065 1.108101214464033 1.1416144557052856 1.1611515924623879 1.0035646582855713 1.0977564687413508 1.143614203018691 1.0 16.807467427343973 -5.269326856185921 24.897717860001173 1.1017498503114713 1.0501803321680334 0.10347350731093141 0.05434640469184887 1020.9900442602363 3222879.477669309 0.014022396705228812 0.030100833760087976 5.378648254519556e-06 5.269326856185921 -0.05156951814343791 GLLPGGTQVLDGTSGFS(ph)PAPK ddPTM_A459_Selumetinib_30min_R1 2 GLLPGGTQVLDGTSGFSPAPK 21 0 Q96S94;Q96S94-3 Q96S94 CCNL2 Cyclin-L2 1 GLLPGGTQVLDGTS(0.002)GFS(0.998)PAPK;GLLPGGTQVLDGTS(0.006)GFS(0.993)PAPK 208.98 1.0125e-17 80613000.0 16394.0 19315.3 22448.5 22146.4 18794.7 17649.8 20220.9 17956.3 11427.0 16552.800000000003 True False 16775.948302829016 17053.85569656065 19400.11700078397 18278.946979415065 17094.7227034738 17472.25903673621 18695.62123306001 17480.040593717444 19390.784404941038 18677.513117925842 0.8981896142655208 0.9130688646227276 1.0386884419941649 0.9786606420247537 0.915256897186545 0.9354703126920637 1.0009695142506305 0.9358869397307975 1.038188771840863 1.0 14.189014754763999 -5.033388109715365 22.272253586286592 0.9749122449037753 0.901909358140858 0.3541836214150291 0.04005619410976908 162.3964468715151 108331.5636682606 0.010267638569720483 0.027237128883701608 9.260019266580764e-06 5.033388109715365 -0.07300288676291722 GLLPGGTQVLDGTSGFS(ph)PAPK ddPTM_A459_Selumetinib_30min_R2 2 GLLPGGTQVLDGTSGFSPAPK 21 0 Q96S94;Q96S94-3 Q96S94 CCNL2 Cyclin-L2 1 GLLPGGTQVLDGT(0.001)S(0.008)GFS(0.992)PAPK;GLLPGGTQVLDGT(0.031)S(0.342)GFS(0.628)PAPK 230.0 6.5927e-25 52113000.0 236017.0 227392.0 230468.0 260577.0 243682.0 202680.0 230887.0 244812.0 179092.0 228532.0 True False 222900.11999090927 244832.2352194785 215639.93979458508 225085.96307960284 213068.4886152799 230597.33025414607 241623.7029939108 245524.36238919178 214915.40424857536 221933.6873625555 1.0043546008712727 1.1031774316420717 0.97164131483253 1.0142036828861303 0.9600547404378803 1.039037079023688 1.0887202653429953 1.1062960531453616 0.9683766660330618 1.0 17.759769145586723 -6.987120616092737 24.965925937241565 1.0517308914750771 1.0124204767649776 0.061023790992305704 0.05165245018848936 519.3490911003901 1006723.2371652186 0.01825925079480746 0.01609381410870904 1.0300999922580784e-07 6.987120616092737 -0.03931041471009955 GLLPGLLPAPADKLT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 GLLPGLLPAPADKLTPK 17 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GLLPGLLPAPADKLT(1)PK;GLLPGLLPAPADKLT(1)PK 127.37 0.0015196 26122000.0 7473.200000000001 9420.2 11524.400000000001 11919.6 7825.5 7507.5 8495.2 8906.0 5115.8 7816.9 True False 7647.311019684144 8317.278604667828 9959.449778997921 9838.065618603277 7117.684906704237 7431.981366264607 7854.40022447524 8669.783949234956 8681.138956751329 8820.275258053893 0.8670150075760162 0.9429726807078076 1.1291540782589335 1.1153921312852486 0.806968569399804 0.8426019765628494 0.8904937765182893 0.9829380258080357 0.9842254014492896 1.0 13.106607963940666 -4.805156137390911 4.910042559740861 0.9648907302015679 0.8640518217969596 0.08606605653625732 0.09856288211025913 0.5022558191625759 25.339947244075514 0.02763098185256063 0.14994368618052498 1.5661878935876197e-05 4.805156137390911 -0.1008389084046083 GLLPGLLPAPADKLT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GLLPGLLPAPADKLTPK 17 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 GLLPGLLPAPADKLT(1)PK 81.643 0.021115 8813900.0 56494.0 54665.0 50208.0 57915.0 50740.0 47562.0 65314.0 63592.0 47435.0 48338.0 True False 53354.28964340038 58857.629724321065 46977.671942337125 50026.87709105248 44365.58757864469 54113.233775151384 68351.23041723571 63777.04219177763 56923.32544463849 46942.356342793086 1.1365916370662057 1.253827764727394 1.0007523184240295 1.0657086901589454 0.94510780955835 1.1527592134487987 1.4560673077019377 1.358624644362769 1.2126218170421637 1.0 15.518602641494462 -7.011407412391098 24.582795270000258 1.289242337931846 1.0812060159292112 0.26500561543538026 0.13426758014404822 511.9782413869623 1103304.9926007746 0.04929325222334776 0.04053336957406019 9.740754271605618e-08 7.011407412391098 -0.2080363220026349 GLLPSQY(ph)GQEVY(ph)DT(ph)PPMAVK ddPTM_A459_Selumetinib_30min_R1 1 GLLPSQYGQEVYDTPPMAVK 20 0 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 3 GLLPS(0.156)QY(0.844)GQEVY(1)DT(1)PPMAVK 46.159 0.046259 0.0 2362.6 2606.6 2321.1 2447.7 3177.4 2501.3 2447.3 2433.6 1617.2 1891.2 True False 2417.643983180667 2301.418060224537 2005.907368889666 2020.255144019535 2890.004731015533 2476.139192998689 2262.698190667465 2369.0530225531297 2744.2702843852862 2133.953941847986 1.1329410329667229 1.0784759760238913 0.9399956248130489 0.9467191884516548 1.3542957391633361 1.160352688237673 1.0603313156365446 1.1101706443118216 1.2860025844835112 1.0 11.059313322781039 -6.219869107864473 24.996821724042732 1.1622159394607376 1.0223476570107664 0.2746032635353981 0.10931940787942816 696.2315749738893 418654.31826333416 0.032930182190288815 0.04251235745817458 6.027412190465855e-07 6.219869107864473 -0.1398682824499713 GLLS(ph)PPMGQSGLR ddPTM_A459_Selumetinib_30min_R1 1 GLLSPPMGQSGLR 13 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 GLLS(0.96)PPMGQS(0.04)GLR 134.4 0.0012257 87899000.0 2138.6 2394.4 2563.0 2724.9 2575.8 2245.6 2167.1 2146.5 1049.8 1871.5 True False 2188.425219008791 2114.0625348736385 2214.9586775512535 2249.0473677079854 2342.8193447944254 2223.011302841664 2003.6339022577806 2089.56784718536 1781.4339256416479 2111.7252549537375 1.0363209957711728 1.0011068106110954 1.0488858208970833 1.06502839914052 1.1094337860943708 1.052699113024703 0.9488137235455258 0.9895074381876144 0.84359171320356 1.0 11.044206430390831 -7.268864412492362 5.985483580630883 0.9440011549811193 1.0531669769511942 0.5586583963656493 0.046491951501345476 0.12373617396642146 19.53046696160505 0.019238004459150262 0.013623952750907314 5.384378575325119e-08 7.268864412492362 0.10916582197007496 GLLS(ph)PPMGQSGLR ddPTM_A459_Selumetinib_30min_R2 3 GLLSPPMGQSGLR 13 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 GLLS(1)PPMGQSGLR;GLLS(1)PPMGQSGLR;GLLS(1)PPMGQSGLR 159.12 0.00036439 120096000.0 521937.0 404958.0 519797.0 533045.0 590335.0 369022.0 433809.0 475385.0 386342.0 518711.0 True False 492929.8310193553 436016.9764548004 486353.8269321828 460443.351446085 516171.83963813976 419851.43085181306 453981.97807622625 476768.2916457763 463621.1952974069 503734.4656569681 0.9785509323378906 0.865569076926569 0.9654964273645291 0.914059654118717 1.0246903375272345 0.8334776742033023 0.9012327109365945 0.9464674826725968 0.9203682235495925 1.0 18.94230391841942 -10.530676132963448 4.041740295637404 1.0000051552679634 0.926492085943617 0.14561031221114462 0.0524087513050181 16221072.440800894 31862862.838155467 1527.5125877011403 0.012569958435978154 2.9466182004193394e-11 10.530676132963448 -0.07351306932434643 GLLS(ph)QGSPLSWEETK ddPTM_A459_Selumetinib_30min_R1 1 GLLSQGSPLSWEETK 15 0 E1CEI4;P48506;D6RGF8;A0A0C4DGB2 E1CEI4 GCLC Glutamate--cysteine ligase catalytic subunit 1 GLLS(0.548)QGS(0.34)PLS(0.111)WEETK 93.424 0.021374 0.0 654.4 839.99 768.19 771.61 584.66 580.86 477.04 716.35 374.43 621.18 True False 669.6462467592596 741.6435802992437 663.8740173656253 636.8627984135779 531.7776062301069 575.0170757786823 441.05648873289255 697.3500709672646 635.3803627148051 700.9145038055898 0.955389342242798 1.0581084800963838 0.9471540591058474 0.9086169496504275 0.758691114740585 0.8203811915100173 0.6292586133375646 0.9949145968317502 0.9065019474772322 1.0 9.453094667593971 -5.79056095546908 2.4739031989957843 0.8390136802436503 1.003619671173936 0.24026909940738805 0.10638805506812546 0.3680643894746249 4.593699376077598 0.0322647795760468 0.05774993534924287 1.6197166423695337e-06 5.79056095546908 0.16460599093028572 GLLS(ph)QGSPLSWEETKR ddPTM_A459_Selumetinib_30min_R1 1 GLLSQGSPLSWEETKR 16 1 E1CEI4;P48506;D6RGF8;A0A0C4DGB2 E1CEI4 GCLC Glutamate--cysteine ligase catalytic subunit 1 GLLS(0.912)QGS(0.088)PLSWEETKR 61.957 0.034477999999999995 14348000.0 1268.9 2263.3 2223.0 2401.7 1845.2 1789.0 1708.8 1694.1 936.0 1691.7 True False 1298.4629011504055 1998.3117838203768 1921.1288100649374 1982.2881804925912 1678.3019857965191 1771.004284282035 1579.9038402372266 1649.166964787663 1588.3236372647962 1908.8461735534265 0.6802344364570994 1.0468689470668058 1.0064345868628304 1.0384745549204986 0.8792232758453573 0.9277878483970289 0.8276747818270475 0.8639601177069413 0.8320857171576276 1.0 10.898485130938035 -6.400964927147197 19.739860270445796 0.880552894284043 0.9554548266405095 0.05051230199686996 0.10747831488103046 9.239169439004558 1458.3775774241515 0.03289390151034142 0.037298095947730446 3.9722362725041977e-07 6.400964927147197 0.07490193235646647 GLLSDS(ph)MTDVPVDTGVAAR ddPTM_A459_Selumetinib_30min_R1 7 GLLSDSMTDVPVDTGVAAR 19 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 GLLS(0.001)DS(0.999)MTDVPVDTGVAAR;GLLS(0.027)DS(0.953)MT(0.02)DVPVDTGVAAR;GLLS(0.051)DS(0.798)MT(0.15)DVPVDTGVAAR;GLLS(0.196)DS(0.658)MT(0.146)DVPVDTGVAAR;GLLS(0.016)DS(0.865)MT(0.12)DVPVDTGVAAR;GLLS(0.002)DS(0.984)MT(0.015)DVPVDTGVAAR;GLLS(0.001)DS(0.867)MT(0.132)DVPVDTGVAAR 257.72 3.7030000000000003e-47 104674800.0 9589.54 11733.39 12037.099999999999 12827.499999999998 12398.6 11022.75 11944.539999999999 11849.33 7114.070000000001 10059.3 True False 9812.957624003351 10359.639244094978 10402.527935057431 10587.417926997014 11277.14881915062 10911.871142856235 11043.55373119568 11535.047276351697 12072.057198885008 11350.509140879576 0.8645389825432027 0.9127026035144171 0.9164811733063206 0.9327703097357773 0.993536825457041 0.9613552138869649 0.9729566836276642 1.0162581372502044 1.0635696645013686 1.0 13.470469392356177 -5.7781773278936015 0.42332015630719116 1.0290684789209301 0.8344505629711022 0.8176459600962599 0.023643129790577203 1.0319069966445606 0.2645733476667818 0.021741682295995407 0.0939178079102065 1.6665665935283579e-06 5.7781773278936015 -0.1946179159498279 GLLSDS(ph)MTDVPVDTGVAAR ddPTM_A459_Selumetinib_30min_R2 12 GLLSDSMTDVPVDTGVAAR 19 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 1 GLLS(0.029)DS(0.558)MT(0.414)DVPVDTGVAAR;GLLS(0.087)DS(0.885)MT(0.028)DVPVDTGVAAR;GLLS(0.007)DS(0.87)MT(0.123)DVPVDTGVAAR;GLLS(0.286)DS(0.711)MT(0.003)DVPVDTGVAAR;GLLS(0.162)DS(0.824)MT(0.014)DVPVDTGVAAR;GLLS(0.028)DS(0.958)MT(0.013)DVPVDTGVAAR;GLLS(0.289)DS(0.69)MT(0.022)DVPVDTGVAAR;GLLS(0.124)DS(0.852)MT(0.024)DVPVDTGVAAR;GLLS(0.007)DS(0.989)MT(0.004)DVPVDTGVAAR;GLLS(0.081)DS(0.705)MT(0.214)DVPVDTGVAAR;GLLS(0.004)DS(0.871)MT(0.125)DVPVDTGVAAR;GLLS(0.001)DS(0.969)MT(0.03)DVPVDTGVAAR 303.07 1.8060999999999998e-100 21534900.0 162007.6 149770.4 166828.80000000002 170613.9 185770.3 117602.09999999999 131288.5 139449.00000000003 108571.1 137732.5 True False 153003.86615980737 161257.30809226134 156095.21663746377 147375.99249460595 162432.1741064463 133800.7217894272 137393.67539322734 139854.7735029754 130288.35372999687 133755.8048529881 1.143904493176763 1.2056097921843492 1.1670163908701314 1.1018287591823612 1.2143934559324479 1.0003358129876192 1.0271978516688502 1.0455977866283315 0.9740762569011316 1.0 17.029241978667542 -6.769884888061113 24.99978497642139 1.0134011441321147 1.1651507585625727 0.8409980955775969 0.03413219425206885 71.80807788013898 212559.80448384516 0.01173972396353174 0.010520144275997585 1.6986938401512702e-07 6.769884888061113 0.15174961443045798 GLLSGQTS(ph)PTNAK ddPTM_A459_Selumetinib_30min_R2 1 GLLSGQTSPTNAK 13 0 G3V1P3;Q969J3 G3V1P3 LOH12CR1 Loss of heterozygosity 12 chromosomal region 1 protein 1 GLLSGQT(0.077)S(0.915)PT(0.008)NAK 219.95 1.3037e-08 10006000.0 73604.0 69480.0 71336.0 70445.0 77998.0 58511.0 55778.0 63528.0 53095.0 60436.0 True False 69513.3843401572 74808.89258658794 66746.3194247643 60850.26947559688 68199.19392903279 66570.35914002542 58371.78752201018 63712.855962373476 63715.483598251914 58691.055648414156 1.1843948549259986 1.2746216908199246 1.1372485753980095 1.0367894869725531 1.1620031907004136 1.1342504987269584 0.994560191107883 1.085563298503986 1.085608069139808 1.0 15.840853036975213 -1.5228787452803838 0.20892213944132165 1.0124128563265486 2.150213097871646 0.5391287380574629 0.05624658014963644 40.80325627930148 0.5063732243485519 0.09919048691933267 15.400660527229247 0.029999999999996807 1.5228787452803838 1.1378002415450972 GLLSGQTSPT(ph)NAK ddPTM_A459_Selumetinib_30min_R2 1 GLLSGQTSPTNAK 13 0 G3V1P3;Q969J3 G3V1P3 LOH12CR1 Loss of heterozygosity 12 chromosomal region 1 protein 1 GLLSGQT(0.194)S(0.194)PT(0.612)NAK 158.31 0.00085277 9394500.0 55755.0 55785.0 60623.0 65569.0 64566.0 50381.0 54087.0 59583.0 48959.0 54277.0 True False 52656.36030494901 60063.53012295347 56722.582181331694 56638.38908716606 56454.64185263642 57320.525436817275 56602.15267135729 59756.37666550334 58752.168028756314 52709.88198141798 0.9989845988179629 1.1395117550088216 1.0761280437191707 1.0745307513140139 1.0710447401976464 1.087472088384199 1.073843282201077 1.1336845088473066 1.1146328889423134 1.0 15.685785841394667 GLLSNHTGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 GLLSNHTGSPR 11 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 GLLSNHT(0.008)GS(0.992)PR;GLLSNHT(0.061)GS(0.939)PR;GLLSNHT(0.074)GS(0.926)PR 122.52 0.0041278 11885100.0 7123.5 7855.1 6159.8 7107.1 11321.599999999999 6368.299999999999 10088.699999999999 7164.8 2664.88 5212.4 True False 7289.463690081893 6935.421240263085 5323.332993359423 5865.978401789946 10297.563278990825 6304.240683953764 9327.70123654103 6974.766229449648 4522.106724865607 5881.462313075533 1.239396480340633 1.1792001497390223 0.905103647697395 0.9973673364783511 1.75085084811264 1.0718832066539508 1.5859493336893271 1.1858898107607536 0.768874556045724 1.0 12.521959182842059 -8.16514273118963 5.965924561652332 0.888364399629397 1.2438137709566777 0.24979529603181283 0.2472580098759796 0.3159264060640191 15.63357053498884 0.1767806701579769 0.06474466167692483 6.836869161643272e-09 8.16514273118963 0.3554493713272807 GLLSNHTGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 GLLSNHTGSPR 11 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 GLLSNHT(0.097)GS(0.903)PR;GLLSNHT(0.023)GS(0.977)PR 109.95 0.0060191 36278000.0 45733.0 44097.0 82383.0 112916.0 141646.0 85335.0 69636.0 82905.0 99008.0 98559.0 True False 43191.34294370428 47479.09810579691 77082.56747182818 97536.64600903525 123851.16314869327 97089.12165599738 72874.21198111633 83146.23982433838 118812.36651465704 95713.34558296484 0.45125726909489117 0.49605515110368564 0.8053481675135115 1.0190495945467704 1.2939800859989625 1.0143739210520022 0.7613798424583181 0.8687005904758263 1.241335424971326 1.0 16.546432477343366 -5.414490329320322 2.3892751673012573 1.0216443006512765 0.45362207673040794 0.6932124386357192 0.14679961489962978 0.18570833832209824 2.0312164638317483 0.045173709405417393 0.12184158406496778 3.850433885610157e-06 5.414490329320322 -0.5680222239208685 GLLSQGS(ph)PLSWEETKR ddPTM_A459_Selumetinib_30min_R1 2 GLLSQGSPLSWEETKR 16 1 E1CEI4;P48506;D6RGF8;A0A0C4DGB2 E1CEI4 GCLC Glutamate--cysteine ligase catalytic subunit 1 GLLS(0.35)QGS(0.582)PLS(0.068)WEETKR;GLLS(0.001)QGS(0.998)PLS(0.001)WEETKR 116.85 0.00096946 80142000.0 4731.1 5712.9 6775.6 7413.5 5727.3 5371.4 5081.1 5137.0 2893.0 4179.799999999999 True False 4841.3254248819285 5044.031012144846 5855.510735706695 6118.871393630273 5209.266726236943 5317.368592840986 4697.828536182922 5000.750072672351 4909.209703640018 4716.318044699772 1.0265052905672127 1.0694849169074505 1.2415428052582576 1.2973831144629229 1.104519813308848 1.1274406311119494 0.9960796730963407 1.060308067708077 1.040898781021992 1.0 12.203445294336806 -7.061838232898915 2.626841044063916 1.0292971189952418 1.1569317381975859 0.3688743886356143 0.07613312754769302 0.3514169676109214 4.7872910939881015 0.03545643852905535 0.027248645139227444 8.672848640485484e-08 7.061838232898915 0.1276346192023441 GLLSQGS(ph)PLSWEETKR ddPTM_A459_Selumetinib_30min_R2 1 GLLSQGSPLSWEETKR 16 1 E1CEI4;P48506;D6RGF8;A0A0C4DGB2 E1CEI4 GCLC Glutamate--cysteine ligase catalytic subunit 1 GLLS(0.023)QGS(0.95)PLS(0.023)WEET(0.003)KR 82.367 0.010345 16232000.0 102160.0 41796.0 62544.0 76679.0 48345.0 45351.0 74045.0 59755.0 45468.0 48058.0 True False 96482.3561788824 45001.61880467801 58519.98713275837 66235.18792134705 42271.468890216354 51597.68859461108 77488.23921738395 59928.87715702722 54562.87048206646 46670.44067032046 2.067311874349609 0.964242423219635 1.2538983196268274 1.419210681751042 0.9057439416272411 1.1055753460546185 1.6603279957170347 1.28408637879304 1.1691098198000325 1.0 15.5102214690903 -4.750831724287722 24.975599704301846 1.2161071104482546 2.0673136831213452 0.5935690919609173 0.21575965452311266 333.0314665983789 784066.3897909834 0.05486717434018159 0.7729391141679656 1.774877057773052e-05 4.750831724287722 0.8512065726730906 GLLSQGSPLS(ph)WEETK ddPTM_A459_Selumetinib_30min_R1 1 GLLSQGSPLSWEETK 15 0 E1CEI4;P48506;D6RGF8;A0A0C4DGB2 E1CEI4 GCLC Glutamate--cysteine ligase catalytic subunit 1 GLLSQGS(0.105)PLS(0.894)WEETK 162.76 1.0658e-05 0.0 649.3 1191.0 810.56 915.37 672.24 971.21 977.71 830.57 501.8 687.74 True False 664.4274266821325 1051.557166319121 700.4904040873753 755.5178131229983 611.4360106936117 961.4405091881254 903.960547541163 808.5405855284164 851.5179499780714 776.0181281548931 0.8562009089425715 1.3550677853613626 0.9026727323405485 0.9735826853933972 0.7879145969790659 1.2389407854093608 1.164870400244996 1.041909404166692 1.0972913119989751 1.0 9.599946544627443 -6.788496673069646 24.999533606402203 1.1147383706086242 0.9920907643356736 0.15338753827170748 0.15393420415765977 482.4366697907653 445742.8924615648 0.05473097485513762 0.04828046124291569 1.6274337826164608e-07 6.788496673069646 -0.12264760627295068 GLLSQGSPLS(ph)WEETK ddPTM_A459_Selumetinib_30min_R2 1 GLLSQGSPLSWEETK 15 0 E1CEI4;P48506;D6RGF8;A0A0C4DGB2 E1CEI4 GCLC Glutamate--cysteine ligase catalytic subunit 1 GLLS(0.001)QGS(0.054)PLS(0.946)WEETK 135.47 0.00040962 3330300.0 10560.0 9137.0 9737.9 8643.1 10477.0 8396.5 10450.0 8619.5 8190.4 9347.7 True False 9973.117475029356 9837.778519914418 9111.37411582387 7465.894869820873 9160.785594431616 9553.04165916191 10935.945706282162 8644.581317964958 9828.708858896734 9077.807612758643 1.098626221270913 1.083717450245107 1.0036976442437544 0.8224336963616342 1.0091407512928947 1.0523511916836987 1.2046901821219422 0.952276330004527 1.0827183476638917 1.0 13.1481281980249 -6.766577694391908 5.183461477936196 1.065176751373735 0.9974862108589605 0.07855869254821213 0.09233832478216258 0.4592910457438814 35.424083548589564 0.03421083877089943 0.03186116717817069 1.711678933460645e-07 6.766577694391908 -0.06769054051477441 GLLTDS(ph)PAATVLAEAR ddPTM_A459_Selumetinib_30min_R1 1 GLLTDSPAATVLAEAR 16 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 GLLT(0.006)DS(0.593)PAAT(0.401)VLAEAR 123.63 0.0013516 1843500.0 670.6 1006.5 1014.1 1232.1 922.09 852.97 925.46 868.0 466.92 620.02 True False 686.2236752395472 888.6585120908442 876.3907900525653 1016.9368643814473 838.6871223082123 844.3898962347948 855.6518071078789 844.9778203386408 792.3291375124767 699.6056065062329 0.9808721783498651 1.2702278309756898 1.2526926341102118 1.4535859274483778 1.1987998874059056 1.206951299963992 1.2230488137179554 1.207791665018786 1.1325368609741375 1.0 9.450398040564206 -8.628801878000171 1.0699460282222388 0.9996172623782178 1.2393774068398986 0.29289834773472856 0.10791127909014918 0.8262652928875331 2.0072768035569855 0.10462647788384437 0.03363770960240947 2.350704950868209e-09 8.628801878000171 0.2397601444616808 GLLYDS(ph)DEEDEERPAR ddPTM_A459_Selumetinib_30min_R1 10 GLLYDSDEEDEERPAR 16 1 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR 255.39 1.6452e-29 2311647000.0 21779.170000000002 25460.940000000002 25206.34 26255.129999999997 24138.31 20300.48 22871.68 23145.889999999996 11612.359999999999 18823.7 True False 22286.58228611228 22479.961308330116 21783.45747651472 21670.164415329346 21955.004122464754 20096.275602561083 21146.450763504803 22531.985808753387 19705.326786782287 21239.905253365025 1.049278799517311 1.0583833138694736 1.0255910851138839 1.02025711305356 1.0336677052260597 0.946156555918593 0.995600051471726 1.0608326892222675 0.9277502207153389 1.0 14.374489710154544 -5.914193305957667 1.0015567931542342 0.9920937831442788 1.0552420824398643 0.32174310624143143 0.03541693360371207 0.7700246882131028 1.5363052280488578 0.014459381356412717 0.0347850986039431 1.218447143223092e-06 5.914193305957667 0.06314829929558552 GLLYDS(ph)DEEDEERPAR ddPTM_A459_Selumetinib_30min_R2 13 GLLYDSDEEDEERPAR 16 1 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLYDS(1)DEEDEERPAR;GLLY(0.001)DS(0.999)DEEDEERPAR;GLLY(0.001)DS(0.999)DEEDEERPAR;GLLYDS(1)DEEDEERPAR 252.46 6.3222e-29 5120720000.0 1748110.7 1641312.7 2101226.8 2177128.6 2368562.3 1739894.8 1842961.0999999999 1998127.5999999999 1781240.5 2015814.0 True False 1650957.705535586 1767196.1064378603 1966036.155330755 1880599.928923681 2071002.3286583747 1979549.5155075537 1928662.4429081373 2003941.8205081674 2137538.3720179326 1957612.2121062344 0.8433527821934087 0.9027304261330177 1.0043031725958929 0.9606600925830482 1.0579226650972624 1.0112061537344603 0.9852116936035307 1.023666387099254 1.0919110326340435 1.0 20.900663575798 -4.517162616882367 0.7713291642313187 1.0270255223559879 0.6486166610312502 0.7597221789499367 0.03355361139621543 1.8132936254062886 0.6234765652721675 0.012931763989239075 0.6497884486386406 3.0397466122385868e-05 4.517162616882367 -0.3784088613247377 GLLYDS(ph)DEEDEERPARK ddPTM_A459_Selumetinib_30min_R1 2 GLLYDSDEEDEERPARK 17 2 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 GLLYDS(1)DEEDEERPARK;GLLYDS(1)DEEDEERPARK 72.207 0.010934 47726000.0 7200.700000000001 7302.1 10373.4 11769.3 10084.900000000001 7198.5 8536.4 7343.7 3438.3999999999996 5193.6 True False 7368.462299876843 6447.166737345808 8964.74925700748 9714.01269212286 9172.722575633712 7126.089625715052 7892.492475304934 7148.921220300551 5834.713669200077 5860.24914994802 1.2573633153365502 1.1001523266980882 1.5297556516154258 1.6576108700444967 1.5652444701459618 1.2160045491885374 1.3467844580251231 1.2199005600920503 0.995642594692724 1.0 12.516746287151477 -7.99080515632647 1.337568025817486 0.976615752901701 1.4025537223174138 0.4792525838407914 0.1597121802951271 0.43142720838696574 1.387588654914442 0.1617287283000171 0.0551856223686046 1.0213976249859503e-08 7.99080515632647 0.4259379694157128 GLLYDS(ph)DEEDEERPARK ddPTM_A459_Selumetinib_30min_R2 2 GLLYDSDEEDEERPARK 17 2 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 GLLY(0.049)DS(0.951)DEEDEERPARK;GLLY(0.001)DS(0.999)DEEDEERPARK 87.088 0.012231 109668000.0 88292.0 99656.0 109316.0 101794.0 90834.0 62907.0 54455.0 50056.0 49054.0 89444.0 True False 83385.08410087996 107299.29475545489 102282.72757426155 87929.48159555545 79422.62085373694 71571.86823711052 56987.26540053542 50201.65467278308 58866.170683278084 86861.5193165788 0.9599772690709164 1.2352914800440895 1.1775378600215134 1.0122949988369916 0.914359102611022 0.823976702229407 0.6560703272163301 0.5779504557111904 0.6777013704852687 1.0 16.406429567102066 -6.523371533812444 1.3923127395296433 0.6975670200827845 1.1299439622564018 0.6314600428638604 0.12649196051391534 0.2371981340515707 0.9474117210602877 0.05219390619480596 0.05804492759802961 2.996597867959342e-07 6.523371533812444 0.43237694217361733 GLMAGGRPEGQYS(ph)EDEDTDTDEYK ddPTM_A459_Selumetinib_30min_R1 1 GLMAGGRPEGQYSEDEDTDTDEYK 24 1 H0YE35;Q9NPQ8-2;Q9NPQ8-4;Q9NPQ8;Q9NPQ8-3;H0YC88 H0YE35 RIC8A Synembryn-A 1 GLMAGGRPEGQY(0.114)S(0.715)EDEDT(0.159)DT(0.012)DEYK 82.406 0.00010026 3785600.0 1266.2 1280.7 1042.9 1017.8 1632.1 1199.6 1332.8 1194.2 694.28 1269.4 True False 1295.6999964036906 1130.755048618723 901.2799082396415 840.0603364722325 1484.4768431706582 1187.5331131496537 1232.2658229565636 1162.5259366917119 1178.1424517950875 1432.339855003084 0.9046037446196041 0.7894460554658576 0.6292360748683495 0.5864951209295393 1.0363998725480288 0.8290861341333665 0.8603166480722624 0.8116271655997513 0.8225299656920814 1.0 10.484158129886286 -6.2571383278996935 24.999996745693757 0.8790454636257775 0.7248589452043477 0.36087599678997584 0.10711878326942702 477.1766827062164 2773602.640690578 0.03361069756397024 0.041859197802989384 5.531738887643091e-07 6.2571383278996935 -0.15418651842142983 GLMAGGRPEGQYS(ph)EDEDTDTDEYK ddPTM_A459_Selumetinib_30min_R2 2 GLMAGGRPEGQYSEDEDTDTDEYK 24 1 H0YE35;Q9NPQ8-2;Q9NPQ8-4;Q9NPQ8;Q9NPQ8-3;H0YC88 H0YE35 RIC8A Synembryn-A 1 GLMAGGRPEGQY(0.145)S(0.854)EDEDTDTDEYK;GLMAGGRPEGQY(0.14)S(0.857)EDEDT(0.001)DT(0.002)DEYK 102.15 1.9115e-06 50251000.0 103534.0 81832.0 87939.0 104909.0 88821.0 83561.0 122385.0 127984.0 114163.0 79228.0 True False 97779.99475944036 88108.25126864816 82281.1004807438 90620.21322188071 77662.51191018525 95070.76925876588 128076.14500127685 128356.41225110827 136998.78998073732 76940.48178093458 1.2708523848062216 1.1451481616596908 1.0694123376432065 1.1777962799855497 1.0093842683661174 1.235640420467498 1.6646132443768165 1.6682558944271422 1.780581389791672 1.0 16.231455242986797 -7.1482722635783675 4.5015557850153005 1.5826021999404665 1.1333871512559937 0.43524200656349354 0.2086691373540616 0.1830447919669496 5.987497759870916 0.07755025469672146 0.059326443560611127 7.107677864790287e-08 7.1482722635783675 -0.4492150486844728 GLMAGGRPEGQYS(ph)EDEDTDTDEYKEAK ddPTM_A459_Selumetinib_30min_R2 2 GLMAGGRPEGQYSEDEDTDTDEYKEAK 27 2 H0YE35;Q9NPQ8-2;Q9NPQ8-4;Q9NPQ8;Q9NPQ8-3;H0YC88 H0YE35 RIC8A Synembryn-A 1 GLMAGGRPEGQY(0.452)S(0.523)EDEDT(0.023)DT(0.002)DEYKEAK;GLMAGGRPEGQY(0.137)S(0.583)EDEDT(0.184)DT(0.05)DEY(0.046)KEAK 50.132 0.01204 24542000.0 46671.0 61732.0 56254.0 70642.0 46991.0 35262.0 37886.0 43626.0 24951.6 44035.0 True False 44077.21265881581 66466.64590033452 52634.67888472417 61020.43773575288 41087.5704751299 40119.02042343446 39647.77406968479 43752.94443732691 29942.617205954277 42763.59513332978 1.0307181265136944 1.554281058295089 1.23082913680709 1.4269248772349776 0.9608072087256856 0.9381582698636544 0.927138467803505 1.0231353164043506 0.7001894277737448 1.0 15.384095525007247 -6.314713905014924 6.7463135765295625 0.9250641462228132 1.3220773029610482 0.6131555779977634 0.15005473507451852 0.14952961587287636 15.63156840048973 0.043656935376614935 0.04983069638341698 4.844914251070932e-07 6.314713905014924 0.397013156738235 GLNNDS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 GLNNDSPER 9 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 GLNNDS(1)PER 113.67 0.00898 9154000.0 4503.3 5334.4 5378.7 5513.5 5381.2 4584.2 4788.1 4319.9 2651.5 4001.8 True False 4608.218128103567 4709.845968104719 4648.302083084245 4550.670726213059 4894.471410128025 4538.087110120574 4426.929762078572 4205.322218987207 4499.401842102142 4515.470010832951 1.0205400804452487 1.0430466721748668 1.0294171087245891 1.0077955816992825 1.0839339865807593 1.0050088029005537 0.9803917978544948 0.9313143944923394 0.9964415290784215 1.0 12.140660448892291 -7.10364796847015 3.565977179272596 0.9714801305690502 1.0358449158940133 0.5346706322794573 0.02591064490321381 0.1768326809291272 4.136344146321411 0.010106373763638857 0.007752798555887471 7.876840139123189e-08 7.10364796847015 0.06436478532496304 GLNNDS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 GLNNDSPER 9 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 GLNNDS(1)PER;GLNNDS(1)PER 96.334 0.021576 33438300.0 175974.0 145486.0 164717.0 177170.0 182735.0 138069.0 151385.0 159630.0 129318.0 153555.0 True False 166194.0695597363 156644.30838877868 154119.28755030973 153039.140364703 159778.1956283727 157086.7514844072 158424.70246368667 160094.49687183095 155185.21344681698 149121.4681661959 1.1144878842965318 1.0504477344214354 1.033515089715612 1.0262716847324815 1.071463402239977 1.0534147324068321 1.0623869548221072 1.0735845002102957 1.0406631275509106 1.0 17.1861284435764 -8.577967674008262 0.005564903638243236 6.702547723674607e-08 2.084453148995792 0.3193961786991488 0.024325268389177836 8466.323733203726 29.40205869795863 5550.344275036398 5460.428407952807 2.642605447969165e-09 8.577967674008262 2.084453081970315 GLNPDGTPALSTLGGFS(ph)PASKPS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 GLNPDGTPALSTLGGFSPASKPSSPR 26 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 2 GLNPDGTPALS(0.034)T(0.002)LGGFS(0.938)PAS(0.073)KPS(0.476)S(0.476)PR 83.31700000000002 0.00021849 54759000.0 1717.7 2693.1 2855.3 2872.9 2555.2 2711.5 2120.8 2130.0 1269.9 2268.2 True False 1757.7190679376242 2377.7906000117764 2467.5659430402243 2371.201946012061 2324.0826111572014 2684.2247718450176 1960.8263485341256 2073.5054807849147 2154.927550173681 2559.345564138962 0.6867845798419847 0.9290619576070159 0.964139418144726 0.9264876065338219 0.9080769098639051 1.0487934140101431 0.766143648598623 0.8101701895353479 0.8419838181948132 1.0 11.321559238608913 -10.31001676645747 17.279623353325327 0.9999999996316224 0.8822881689492748 0.121415397525098 0.09887704838818169 0.0 0.0 0.09802638414550646 0.023774890348782097 4.897599112368116e-11 10.31001676645747 -0.1177118306823477 GLNPDGTPALSTLGGFS(ph)PASKPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 GLNPDGTPALSTLGGFSPASKPSSPR 26 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 2 GLNPDGT(0.001)PALS(0.003)T(0.001)LGGFS(0.91)PAS(0.135)KPS(0.689)S(0.262)PR 90.378 0.00059959 0.0 17949.0 15471.0 14540.0 17402.0 17289.0 10861.0 14772.0 13724.0 10373.0 13970.0 True False 16951.46643553996 16657.57595289439 13604.512229955013 15031.817579875602 15117.001254378943 12357.004163658365 15458.927270162696 13763.934567869499 12447.889845836089 13566.649801580941 1.249495393738591 1.2278326776705961 1.0027908458556702 1.1079977591906236 1.1142766619226316 0.910836820024527 1.1394800850804925 1.0145418927424197 0.9175360186849902 1.0 13.727776879865958 -1.5228787452887547 0.3918277838194414 0.9968359447571282 5.265140291140996 0.5467575673195233 0.07569280916736008 54.515192448931856 0.7322106462468944 0.05552733007904966 178.4423674217136 0.029999999999418568 1.5228787452887547 4.268304346383868 GLNPDGTPALSTLGGFS(ph)PASKPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GLNPDGTPALSTLGGFSPASKPSSPR 26 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 2 GLNPDGTPALS(0.02)T(0.007)LGGFS(0.967)PAS(0.047)KPS(0.386)S(0.574)PR 86.727 0.00015247 9375500.0 74586.0 73880.0 77086.0 72737.0 70753.0 55494.0 64420.0 61394.0 49438.0 72131.0 True False 70440.80871141475 79546.35843835815 72126.37068489086 62830.09512167634 61864.375600154584 63137.79477562454 67415.65764580836 61572.64637567613 59326.981413134534 70048.39061115484 1.0056021001601343 1.1355915210090608 1.029664922428712 0.8969527290134626 0.8831662663539197 0.901345401725335 0.9624155110149349 0.8790015850252955 0.8469428190358312 1.0 16.096064284110206 -5.668386356219545 4.156283920233814 0.9054881760981366 1.0729284549002482 0.6422219068437113 0.05064160662748528 0.12035210315364196 3.806727038480616 0.013526537850538917 0.02413213927983115 2.1459205749921318e-06 5.668386356219545 0.16744027880211165 GLNPDGTPALSTLGGFSPAS(ph)KPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 GLNPDGTPALSTLGGFSPASKPSSPR 26 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 2 GLNPDGT(0.032)PALS(0.168)T(0.039)LGGFS(0.314)PAS(0.477)KPS(0.614)S(0.355)PR 51.966 0.045959 9376800.0 30551.0 30691.0 29742.0 37257.0 38852.0 22083.0 32113.0 30790.0 26268.0 32506.0 True False 28853.097725342985 33044.90101288096 27828.432100641152 32182.532328090147 33971.06441871312 25124.732800485006 33606.31813070233 30879.593802441093 31522.333989243445 31567.467319269163 0.9140137038403048 1.0468024146083443 0.88155415888098 1.0194841417779987 1.0761415882729615 0.7959058782377694 1.0645870886888866 0.9782094169965868 0.9985702581214627 1.0 14.946150896376984 GLNPDGTPALSTLGGFSPASKPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 GLNPDGTPALSTLGGFSPASKPSSPR 26 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 1 GLNPDGTPALSTLGGFSPAS(0.01)KPS(0.495)S(0.495)PR;GLNPDGTPALSTLGGFSPAS(0.019)KPS(0.607)S(0.374)PR 168.52 2.2727e-17 32974000.0 54539.0 56304.0 59734.0 66254.0 65803.0 48043.0 56092.0 55654.0 47334.0 63180.0 True False 51507.94071691536 60622.33575410547 55890.77947346173 57230.090905475154 57536.23885371605 54660.48715906817 58700.38914418941 55815.94392598435 56802.122622462666 61355.82923864592 0.8394954702115293 0.9880452518751316 0.9109285974454413 0.9327571905658133 0.9377469030681107 0.8908768382294052 0.9567206551128488 0.9097089000115381 0.9257820051869655 1.0 15.904912796203368 -11.930645427430662 1.755198474193506 1.397006331730446 0.9236167155125704 0.28231746574945116 0.03746665771596254 2300262.120485108 210209.23191062897 3612371.6867173673 0.009326553458429374 1.173152775905581e-12 11.930645427430662 -0.47338961621787556 GLNPDGTPALSTLGGFSPASKPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 GLNPDGTPALSTLGGFSPASKPSSPR 26 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 1 GLNPDGTPALSTLGGFSPAS(0.007)KPS(0.258)S(0.735)PR 165.6 3.2374999999999996e-17 72249000.0 2538.7 3030.6 3668.1 4258.7 2971.2 2946.7 2796.8 2839.5 1708.6 2545.0 True False 2597.846770549714 2675.7759431122836 3169.9921674310394 3514.9979906998383 2702.455484607965 2917.0588733895306 2585.8351242834015 2764.187236004115 2899.369408793409 2871.6755403992825 0.9046449482201967 0.9317821270087634 1.103882427814348 1.2240233763355826 0.9410727105445246 1.0158037815734358 0.9004621475878374 0.9625694815159299 1.0096438013294065 1.0 11.487677038453926 GLNSSFET(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 GLNSSFETSPK 11 0 M0QZ79;M0QXD7;M0R025;M0QYG0;M0QYA8;Q8IV63-2;Q8IV63 M0QZ79 VRK3 Inactive serine/threonine-protein kinase VRK3 1 GLNSS(0.01)FET(0.495)S(0.495)PK;GLNSSFET(0.5)S(0.5)PK 121.21 0.010542 31596000.0 433640.0 392280.0 377260.0 354185.0 342985.0 275670.0 382210.0 326818.0 247624.0 326212.0 True False 409540.024798459 422366.6146209947 352987.50232963066 305944.39199679537 299896.15797519585 313641.04021689546 399983.5223347473 327768.98627236765 297155.7191926459 316793.4119594355 1.2927668611078929 1.333255676021058 1.1142513985575866 0.9657536440056105 0.9466615991799624 0.9900491246865206 1.2626005063071326 1.0346458414177424 0.9380110443417171 1.0 18.273182807858504 -5.392294316602781 3.561382480454697 1.0273666935794075 1.3136953575878652 0.6318511613070921 0.08810590894720792 0.16289902718835797 3.7009113974313212 0.025740353983988537 0.05941207878691181 4.052338198618909e-06 5.392294316602781 0.2863286640084577 GLNSSFETS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GLNSSFETSPK 11 0 M0QZ79;M0QXD7;M0R025;M0QYG0;M0QYA8;Q8IV63-2;Q8IV63 M0QZ79 VRK3 Inactive serine/threonine-protein kinase VRK3 1 GLNSSFET(0.088)S(0.911)PK 124.12 0.0036652 13191000.0 119720.0 109350.0 94047.0 95093.0 91660.0 75549.0 103430.0 95222.0 62058.0 87237.0 True False 113066.44167713202 117736.79338433217 87996.11841063124 82141.16935542504 80144.85134920325 85955.1889844605 108239.6999426568 95499.08025514937 74471.33404539627 84718.24114105341 1.3346174348553776 1.389745488085663 1.0386915170266608 0.9695806741155353 0.9460164690596492 1.0146007262042611 1.277643379805783 1.1272552282588844 0.8790472163061515 1.0 16.370385016997965 -5.264482389698689 24.08246030300067 1.0390572037321872 1.362181493648283 0.6188152228154865 0.10364955115995728 102.39091615275198 810338.4936451777 0.029194885352044498 0.06534875556667984 5.438981859189842e-06 5.264482389698689 0.32312428991609576 GLNSSFETS(ph)PKK ddPTM_A459_Selumetinib_30min_R2 1 GLNSSFETSPKK 12 1 M0QZ79;M0QXD7;M0R025;M0QYG0;M0QYA8;Q8IV63-2;Q8IV63 M0QZ79 VRK3 Inactive serine/threonine-protein kinase VRK3 1 GLNS(0.001)S(0.005)FET(0.113)S(0.882)PKK 60.937 0.047872000000000005 7875500.0 55104.0 51669.0 44603.0 54232.0 47555.0 36427.0 51998.0 40187.0 35203.0 49115.0 True False 52041.54027878952 55631.846157979446 41733.29154007451 46845.508044581824 41580.71575290594 41444.48859861739 54416.01003208228 40303.937516684004 42244.58365400246 47696.92233390466 1.091088014326588 1.1663613381284008 0.8749682264175987 0.9821494920917021 0.8717693662039259 0.8689132667404241 1.1408704664661657 0.8450007997273765 0.8856878303020721 1.0 15.541608558215016 -5.257852861755437 24.97249388501057 0.9327422035372527 1.1287246907744564 0.45078617703744217 0.08611471019180664 261.4743528569299 1820595.1534709807 0.021913461576282836 0.05345534160824941 5.522645138829016e-06 5.257852861755437 0.19598248723720368 GLNVIGASDQS(ph)PLQSPSNLR ddPTM_A459_Selumetinib_30min_R2 1 GLNVIGASDQSPLQSPSNLR 20 0 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 GLNVIGAS(0.061)DQS(0.939)PLQSPSNLR 199.97 7.403e-24 0.0 5760.3 6325.4 6856.9 8541.8 10233.0 6772.0 6170.4 6774.2 5864.1 6577.7 True False 5440.165586307913 6810.537840633324 6415.734519228236 7378.392104573115 8947.439055819295 7704.78152990466 6457.335826415647 6793.911800470816 7037.083856643919 6387.78471008296 0.8516513679180118 1.0661814932308313 1.0043755089461857 1.1550783940677438 1.4007108038090237 1.206174265350999 1.0108881434627723 1.0635787066753821 1.1016469990818658 1.0 12.641099974535575 -4.501712904469496 1.1866211961927855 1.136381634678984 0.5686501366487897 0.3319193779563848 0.11385019470122003 3.423612903258699 2.6570787139601504 0.03790734191009126 2.8153532229974236 3.149829858486341e-05 4.501712904469496 -0.5677314980301942 GLNVIGASDQSPLQS(ph)PSNLR ddPTM_A459_Selumetinib_30min_R2 1 GLNVIGASDQSPLQSPSNLR 20 0 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 GLNVIGAS(0.001)DQS(0.016)PLQS(0.949)PS(0.034)NLR 144.75 7.027899999999998e-06 0.0 7838.6 5454.6 7729.9 7646.4 6541.3 5266.5 4861.0 4365.6 4119.5 4886.8 True False 7402.961992401995 5872.950280696642 7232.566649678766 6604.947129224268 5719.5234140360335 5991.9125704729595 5087.046131888766 4378.303173236013 4943.515108447099 4745.705386568773 1.5599286911812418 1.2375294718711745 1.5240235245424782 1.391773528107643 1.205199848735521 1.2625968285834144 1.071926240150948 0.9225821698977403 1.041681837738635 1.0 12.212406825453304 -6.920968336859537 0.9450096260073075 0.97255513797446 1.4306350071447327 0.786637011062623 0.09582644857309236 0.24537642349502417 0.46149148377531035 0.06009676418330835 0.04696145905104324 1.1995867583233206e-07 6.920968336859537 0.45807986917027266 GLPFYAGLS(ph)PAGK ddPTM_A459_Selumetinib_30min_R1 1 GLPFYAGLSPAGK 13 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 GLPFYAGLS(1)PAGK 147.7 0.00056637 19078000.0 1936.4 2929.6 3162.1 2964.4 2670.0 2271.9 2564.6 1967.5 1363.3 1852.2 True False 1981.514352421501 2586.6010700659103 2732.7041881719924 2446.723188679785 2428.4989714267867 2249.0467487201545 2371.150157228695 1915.3155086593047 2313.4205285075827 2089.9479119558155 0.9481166210344256 1.237639012565302 1.307546552973501 1.1707101285553534 1.1619901900589227 1.0761257425863073 1.1345498821593716 0.9164417436925084 1.1069273618128774 1.0 11.029251270939787 -7.165562665174789 1.307650978297594 1.0152770614975606 1.1789973479136755 0.26805498232897573 0.10089402022017878 0.565744958463329 1.9155746982688593 0.060556612575891865 0.03807587976020535 6.83026155728669e-08 7.165562665174789 0.1637202864161149 GLPFYAGLS(ph)PAGK ddPTM_A459_Selumetinib_30min_R2 1 GLPFYAGLSPAGK 13 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 GLPFYAGLS(1)PAGK 88.803 0.023309 6549300.0 27394.0 29409.0 29840.0 29367.0 29494.0 22495.0 25288.0 23150.0 19658.0 25380.0 True False 25871.551146870665 31664.575735160684 27920.126887335482 25367.163939099337 25788.70004029456 25593.48206072141 26463.942107221366 23217.362667311187 23590.14929041219 24647.21345484067 1.0496744873116493 1.284712196499512 1.132790404014293 1.0292102182495309 1.0463130076568434 1.0383925187978966 1.0737092919534033 0.9419873248491439 0.9571122242128807 1.0 14.5891369282976 -5.713328669830343 3.521366803459967 1.0135950013807338 1.1757540748457183 0.5108086367815367 0.06470739329677729 0.17615748091940325 4.456693151176769 0.018233039541583042 0.032296570219386575 1.93495705306585e-06 5.713328669830343 0.16215907346498448 GLPLGSAVSSPVLFS(ph)PVGR ddPTM_A459_Selumetinib_30min_R1 1 GLPLGSAVSSPVLFSPVGR 19 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 GLPLGSAVSSPVLFS(1)PVGR 142.58 8.776799999999999e-05 17180000.0 953.77 1075.5 893.45 976.16 865.92 822.93 1052.5 1108.2 453.13 957.37 True False 975.9909852866427 949.5799600136153 772.1243973695539 805.6919807926251 787.5976888905931 814.6520713606565 973.1090776273888 1078.8069360590805 768.9285146942279 1080.2577650735022 0.9034797220089734 0.8790309042110931 0.7147594049620346 0.7458330843266883 0.7290831080830081 0.7541274848463843 0.9008119257177264 0.9986569603465678 0.711800960432725 1.0 10.077159885960269 -7.271957669309086 22.633313965084618 0.9027055869694944 0.7839839842786033 0.2636010436465408 0.09412079148688235 286.3472213225194 616156.8585790603 0.039561256253919166 0.02706148051889952 5.346164659340086e-08 7.271957669309086 -0.11872160269089116 GLPLGSAVSSPVLFS(ph)PVGR ddPTM_A459_Selumetinib_30min_R2 3 GLPLGSAVSSPVLFSPVGR 19 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 GLPLGSAVSSPVLFS(1)PVGR;GLPLGSAVSSPVLFS(1)PVGR;GLPLGS(0.001)AVS(0.326)S(0.246)PVLFS(0.427)PVGR 181.32 4.0109e-13 19396100.0 39192.0 38040.6 40153.9 46790.0 50701.7 39393.7 34915.9 38145.9 33131.2 35103.1 True False 37013.86553800668 40958.19170019223 37570.4417902607 40417.12128274793 44332.09916705104 44819.82459459614 36539.55853454329 38256.89825360631 39758.36576307379 34089.582294192995 1.0857823137455052 1.2014870509918 1.1021091859098742 1.1856150343512073 1.300458855273296 1.314766024640642 1.0718687668040932 1.1222460258811444 1.166290787019894 1.0 15.057043301532785 -8.909866667456987 0.7785549899195717 1.0009644636312212 1.186463159933816 0.30808998775186447 0.07869584578762048 1.7454820000784252 1.8979153019921924 0.08678861790436906 0.029755825354386745 1.2306465330298366e-09 8.909866667456987 0.18549869630259486 GLPPS(ph)MER ddPTM_A459_Selumetinib_30min_R1 6 GLPPSMER 8 0 P38159;P38159-2;H3BUY5 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER 156.83 0.00056044 510895000.0 40289.6 52467.0 53784.6 57202.799999999996 52679.00000000001 45346.6 51887.2 45686.799999999996 24928.66 37043.100000000006 True False 41228.269290085394 46324.139248753454 46480.94673766021 47213.40480954393 47914.193751232844 44890.45437541853 47973.30672937563 44475.037652358806 42302.11530271091 41797.94271534961 0.986370778362376 1.1082875433422152 1.112039103316701 1.1295628861706053 1.1463289970402573 1.0739871739891458 1.1477432527261258 1.064048485717123 1.012062138818525 1.0 15.35114431450143 -8.131830953829045 3.162358301871631 1.0043103896030152 1.103372314011352 0.4169081292866986 0.044068744426698885 0.2481260711028501 4.413002605909289 0.035774413768512855 0.011604678188079249 7.381915102352487e-09 8.131830953829045 0.09906192440833683 GLPPS(ph)MER ddPTM_A459_Selumetinib_30min_R2 9 GLPPSMER 8 0 P38159;P38159-2;H3BUY5 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER;GLPPS(1)MER 148.91 0.0014999 584039300.0 1620221.8 1511119.0 1771854.1 1648605.0 1740486.0 1467134.6 1383563.1 1537501.8 1301511.1 1572481.0 True False 1530176.3586177588 1627016.9682865904 1657854.9362548813 1424062.1549977507 1521830.588537741 1669219.0738281226 1447901.525628272 1541975.6756908742 1561849.687258551 1527079.3877337012 1.0020280352867927 1.0654436051954077 1.0856376882378465 0.9325397005791325 0.9965628511273734 1.0930794346621149 0.948150788530428 1.0097547567446905 1.0227691499237976 1.0 20.542343634283164 -5.729122249662557 24.998910333605465 1.0023381279303665 1.0524771292765758 0.20805397615679055 0.04512894229728234 320.9133842597936 248240.25039789485 0.012334245962867182 0.02136137958277661 1.8658543970837358e-06 5.729122249662557 0.0501390013462093 GLPSPYNMSS(ph)APGSR ddPTM_A459_Selumetinib_30min_R1 3 GLPSPYNMSSAPGSR 15 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 GLPSPYNMS(0.039)S(0.959)APGS(0.003)R;GLPSPYNMS(0.356)S(0.606)APGS(0.038)R;GLPSPYNMS(0.224)S(0.705)APGS(0.071)R 144.4 0.00037347 56996000.0 7427.6 7150.9 8664.1 8883.099999999999 9211.5 6388.200000000001 7405.5 7516.700000000001 4150.93 6554.799999999999 True False 7600.648628406296 6313.669303636783 7487.562808494655 7331.833341438877 8378.321451422413 6323.940508021522 6846.897172797743 7317.332698317356 7043.825038067903 7396.17242915883 1.0276462185280233 0.8536400907509454 1.0123564424993021 0.9913010292369198 1.1327915258426828 0.8550288096434694 0.9257352013325687 0.989340468790228 0.9523608468480501 1.0 12.852563143773123 GLPSPYNMSS(ph)APGSR ddPTM_A459_Selumetinib_30min_R2 4 GLPSPYNMSSAPGSR 15 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 GLPSPYNMS(0.067)S(0.933)APGSR;GLPSPYNMS(0.072)S(0.926)APGS(0.002)R;GLPS(0.003)PYNMS(0.096)S(0.898)APGS(0.003)R;GLPS(0.001)PYNMS(0.38)S(0.62)APGSR 176.08 1.9202e-05 81207800.0 143208.0 123659.0 167358.0 146561.0 160650.0 105618.0 121005.0 133817.0 107307.0 140850.0 True False 135249.07266704596 133143.24767364512 156590.36848561311 126599.1389681732 140467.71077077795 120165.92079525549 126631.97226685862 134206.38531540308 128771.3984080914 136783.2945277506 0.9887835582115374 0.9733882206400066 1.1448062354854602 0.9255453263153327 1.0269361566099715 0.878513134298547 0.925785365121232 0.9811606437668839 0.9414263551165325 1.0 17.06153251771879 GLPSPYNMSSAPGS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GLPSPYNMSSAPGSR 15 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 GLPSPYNMSSAPGS(1)R 94.454 0.019937 0.0 7778.8 7654.2 6331.8 5718.1 5165.3 6461.9 5762.5 5468.6 5117.0 6424.6 True False 7346.485437003628 8241.252527867893 5924.418881542585 4939.28491572731 4516.38883563211 7351.968069712185 6030.467668177125 5484.512720624534 6140.542980925789 6239.105104884529 1.1774902511663319 1.3209029803674734 0.9495622820818358 0.7916656047131497 0.7238840762750218 1.17836900422729 0.9665597175876931 0.8790543881574887 0.9842025222685259 1.0 12.607123398151646 -5.286001181963826 10.785154477049893 0.9270448905254285 1.24917115636664 0.5203385070062085 0.12083410985435247 0.5109069387343501 223.68128273019641 0.03306088357405021 0.07006825807766444 5.176054232480757e-06 5.286001181963826 0.3221262658412114 GLPSTAS(ph)GR ddPTM_A459_Selumetinib_30min_R1 2 GLPSTASGR 9 0 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GLPS(0.001)T(0.004)AS(0.995)GR;GLPSTAS(1)GR 94.309 0.023413 42191000.0 7624.200000000001 9015.2 9486.0 9860.1 9395.4 7291.099999999999 8481.0 7689.3 4117.6 6497.6 True False 7801.829025889285 7959.69619294723 8197.85330286819 8138.218632000252 8545.587728892593 7217.758153789127 7841.271341907726 7485.354785633537 6987.266462394789 7331.630251983649 1.064132908745421 1.085665250343694 1.1181487637964524 1.110014874222329 1.1655781095317095 0.9844683795716904 1.0695126557679568 1.0209673058196431 0.9530303932749897 1.0 12.839918314527832 -7.338644618112143 1.0933142267792475 0.9863871162808097 1.1037824048611757 0.540938259611949 0.04284381062745215 0.4108086809790067 0.9406613726596021 0.031463785369287796 0.016766584608768283 4.585169362931461e-08 7.338644618112143 0.11739528858036608 GLPSTAS(ph)GR ddPTM_A459_Selumetinib_30min_R2 2 GLPSTASGR 9 0 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GLPSTAS(1)GR;GLPSTAS(1)GR 110.54 0.010792 65871000.0 103715.0 116316.0 122960.0 136458.0 138147.0 111037.0 117877.0 91351.0 86872.0 119524.0 True False 97950.93550404064 125237.06318511152 115048.88746872578 117872.18499682017 120791.73881015017 126331.33885647127 123358.51406884436 91616.81628602772 104248.82740648546 116073.03155935301 0.8438733286116872 1.078950566747906 0.9911767266102329 1.0155001847827778 1.0406529164217124 1.0883780423351204 1.0627663671019567 0.7893032089816677 0.8981313402948269 1.0 16.824673289404366 -7.74754757588615 24.999995939905496 0.8827879327311063 1.0222520412029947 0.31779260833598655 0.08069146421688339 225.44346113693706 405714.59565951955 0.03691685950406592 0.021176777704078376 1.7883496091009698e-08 7.74754757588615 0.1394641084718884 GLPTGDS(ph)PLGPMTHR ddPTM_A459_Selumetinib_30min_R1 2 GLPTGDSPLGPMTHR 15 0 J3QQZ9;Q9NVS9-4;Q9NVS9-3;Q9NVS9 J3QQZ9 PNPO Pyridoxine-5-phosphate oxidase 1 GLPTGDS(1)PLGPMTHR;GLPTGDS(1)PLGPMTHR 137.52 0.00026546 10540300.0 6555.1 7420.1 6441.8 6303.8 6560.9 6109.200000000001 6438.8 6660.5 3369.4 5006.2 True False 6707.821075995761 6551.3512424891005 5567.038942274547 5202.959666981389 5967.467753420979 6047.746994709786 5953.1161320923775 6483.84190364691 5717.625708760687 5648.794534517443 1.1874783256864887 1.1597786399304324 0.9855268957397332 0.92107433456612 1.056414376015317 1.0706261234595293 1.0538737239804619 1.1478275345344637 1.0121851084904303 1.0 12.463727310663113 -5.166816667789919 5.805781044142773 1.035652555021108 1.1789043484290591 0.5023091159781305 0.05679537062201437 0.20554786205604625 10.123097989315516 0.015912871599400125 0.04381836421938465 6.81056797984068e-06 5.166816667789919 0.14325179340795113 GLPTGDS(ph)PLGPMTHR ddPTM_A459_Selumetinib_30min_R2 5 GLPTGDSPLGPMTHR 15 0 J3QQZ9;Q9NVS9-4;Q9NVS9-3;Q9NVS9 J3QQZ9 PNPO Pyridoxine-5-phosphate oxidase 1 GLPTGDS(1)PLGPMTHR;GLPTGDS(1)PLGPMTHR;GLPT(0.031)GDS(0.969)PLGPMTHR;GLPT(0.007)GDS(0.993)PLGPMTHR;GLPT(0.041)GDS(0.959)PLGPMTHR 154.74 0.00012065 25884800.0 138911.0 111707.0 127040.0 139100.0 123428.0 97461.0 107215.0 111338.0 97712.0 111620.0 True False 131190.88272479182 120274.56770538226 118866.38471069341 120154.34003911582 107921.87117967983 110885.36808712911 112200.7099424921 111661.97514700193 117257.1303013917 108397.24057641125 1.2102788043973582 1.109572227722886 1.0965812789939267 1.1084630881762785 0.9956145618264487 1.0229537901286698 1.035088248979915 1.0301182442766088 1.0817353806966603 1.0 16.72596850550684 -1.6759882111363025 0.4873846108253076 1.0280030803876865 5.483130791295144 0.7648609469872558 0.030288341337836172 42.47271556865256 0.5460744847141765 0.01769240413766857 189.9109688861581 0.021086853891299065 1.6759882111363025 4.455127710907457 GLPWSCSADEVQR ddPTM_A459_Selumetinib_30min_R2 2 GLPWSCSADEVQR 13 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;E7EN40;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;D6RDL0;D6RF17;D6R9D3;E7EQJ0 P31943;E7EQJ0 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 ; 165.63 0.0048912 10073600.0 21393.0 19159.0 24499.0 24133.8 25649.7 20682.1 17361.8 23276.2 17582.4 22524.3 False True 20204.0627029643 20628.433694105326 22922.761012494375 20846.734806872857 22427.355374772604 23530.871541589047 18169.158101754037 23343.929888417668 21099.37129330266 21873.96493384034 0.9236580000047179 0.9430587347331758 1.0479472323296763 0.9530386863984455 1.0252990458111293 1.0757478862547398 0.8306293877999803 1.067201577721431 0.9645883294189919 1.0 14.41692713043061 -5.031283982364437 17.538060305484986 0.9945430182248697 0.9285071260795006 0.12308801502977673 0.06724009522337351 30.709713439983997 17220.3278081942 0.016385106805254707 0.04376371927307494 9.304992290419793e-06 5.031283982364437 -0.06603589214536909 GLQLT(ph)PGIGGMQQHFFDDEDR ddPTM_A459_Selumetinib_30min_R1 1 GLQLTPGIGGMQQHFFDDEDR 21 0 P12270 P12270 TPR Nucleoprotein TPR 1 GLQLT(1)PGIGGMQQHFFDDEDR 78.583 0.0032122 3819300.0 359.18 839.94 858.16 826.95 665.87 772.07 1866.4 2737.2 2240.9 734.7 True False 367.5481951573823 741.5994343224883 741.6265855354594 682.538706274035 605.642176068897 764.3036767834715 1725.6159453527391 2664.6005643213452 3802.643631139615 829.0059015840286 0.44336016722569416 0.8945647225254635 0.89459747405705 0.8233218906763746 0.7305643722338552 0.9219520335417071 2.0815484450177095 3.214211815898948 4.586992232351649 1.0 9.69523856188864 -7.463027751893729 2.51181555080237 3.165296011297754 0.7816973470728938 0.5753808373147977 0.8307917211061265 0.18682218931781233 2.3229035762048365 0.41327656574343996 0.23573802485380196 3.443279271281145e-08 7.463027751893729 -2.38359866422486 GLQLT(ph)PGIGGMQQHFFDDEDR ddPTM_A459_Selumetinib_30min_R2 2 GLQLTPGIGGMQQHFFDDEDR 21 0 P12270 P12270 TPR Nucleoprotein TPR 1 GLQLT(1)PGIGGMQQHFFDDEDR;GLQLT(1)PGIGGMQQHFFDDEDR 139.47 3.0873e-05 5548300.0 17620.7 15978.6 17571.3 18850.5 24436.0 11539.2 17302.4 25837.3 25322.0 35630.0 True False 16641.412035250916 17204.107240703142 16440.781688184903 16283.029381073724 21366.131219388288 13128.620057571736 18106.995884055174 25912.48226540473 30387.107555794995 34601.26932214239 0.48094802188662994 0.4972102925048972 0.4751496696586201 0.47059052167932247 0.6174955901318758 0.37942596658355354 0.5233043827229761 0.748888198989352 0.8782078851757433 1.0 15.078537342589796 -8.035466489224056 1.7097049486136768 0.9740618530688614 0.486804365656699 0.9080290481703395 0.058411392041249094 0.10168153970971709 0.5320432942152303 0.0513104375652699 0.01671630755827099 9.21580996483549e-09 8.035466489224056 -0.4872574874121624 GLQPS(ph)TPPPKPPR ddPTM_A459_Selumetinib_30min_R2 1 GLQPSTPPPKPPR 13 1 A0A1B0GTL5 A0A1B0GTL5 1 GLQPS(0.956)T(0.044)PPPKPPR 94.09 0.0089336 36128000.0 77003.0 59173.0 78063.0 82952.0 76610.0 61114.0 63853.0 61746.0 55162.0 62996.0 True False 72723.48152743223 63711.37882881647 73040.51156856792 71653.79449981842 66985.56689791026 69531.89876234402 66822.29102231913 61925.670637399424 66195.94135505735 61177.14179673533 1.1887361748455052 1.041424573911957 1.1939183398147193 1.1712510979655177 1.0949443686086833 1.1365666443418991 1.0922754653092512 1.012235433344551 1.0820371696179805 1.0 15.90070508513795 -7.527238558026188 3.0951240231465684 1.0352818502180687 1.1354109368566423 0.5029467690177667 0.047100543117128 0.22300588041122776 4.395475310176967 0.02343973760244811 0.013240256387852247 2.9700341433657414e-08 7.527238558026188 0.10012908663857356 GLQPST(ph)PPPKPPR ddPTM_A459_Selumetinib_30min_R2 1 GLQPSTPPPKPPR 13 1 A0A1B0GTL5 A0A1B0GTL5 1 GLQPS(0.229)T(0.771)PPPKPPR 119.21 0.033913 1158700.0 16173.0 14005.0 20158.0 20560.0 18518.0 14072.0 14153.0 15720.0 14332.0 16547.0 True False 15274.169405648647 15079.13846682735 18861.056226370936 17759.692532021738 16191.60328697954 16010.29026710253 14811.142543637472 15765.742597413895 17198.800469538488 16069.245115730839 0.9505219004156045 0.9383849930863128 1.1737362950489243 1.1051976868929612 1.0076144318147788 0.9963311998663462 0.9217074253935078 0.981112832859844 1.0702929942055512 1.0 13.972014536728498 -6.508167993296124 22.177442243298625 0.9897276969093951 1.0455285112368942 0.08876469932726361 0.07200312683871316 382.689900790662 576931.9960763003 0.024850157833256694 0.027129867319744778 3.10335891816547e-07 6.508167993296124 0.05580081432749906 GLQT(ph)PVKDAGGGTGR ddPTM_A459_Selumetinib_30min_R1 4 GLQTPVKDAGGGTGR 15 1 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 GLQT(1)PVKDAGGGTGR;GLQT(0.928)PVKDAGGGT(0.072)GR;GLQT(0.999)PVKDAGGGT(0.001)GR;GLQT(1)PVKDAGGGTGR 154.47 0.0019442 45628000.0 8061.0999999999985 7534.0 10829.6 10350.6 8662.400000000001 8145.9 7984.099999999999 7435.2 4590.759999999999 6142.200000000001 True False 8248.907945829875 6651.91577753842 9358.999802734701 8543.062014825597 7878.887449470938 8063.959641885432 7381.852908964213 7237.994343066668 7790.184424155703 6930.6112000944895 1.1902136345085137 0.9597877568788926 1.350385923049197 1.2326563658208274 1.1368243322267912 1.163527921141427 1.06510850137771 1.044351520248025 1.1240256016741343 1.0 12.758766871723415 -7.2415482208093644 3.7491337021562656 1.0605757020706597 1.1731850253774159 0.257202940809403 0.09490191351789067 0.36655301887744457 11.443730802413622 0.04104054041262801 0.029246838539967818 5.733921978325339e-08 7.2415482208093644 0.11260932330675621 GLQT(ph)PVKDAGGGTGR ddPTM_A459_Selumetinib_30min_R2 1 GLQTPVKDAGGGTGR 15 1 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 GLQT(0.993)PVKDAGGGT(0.007)GR 114.54 0.025816 7955600.0 29014.0 25746.0 25972.0 31270.0 30097.0 19453.0 17256.0 18368.0 14405.0 24266.0 True False 27401.518032244487 27720.635413562064 24300.989796175494 27010.97205624123 26315.94578940616 22132.47417324799 18058.438192115307 18421.4478390139 17286.40250932892 23565.377529360292 1.1627871438980648 1.1763289333695037 1.0312158065746537 1.14621427229791 1.116720738151507 0.9391945512297846 0.7663122803619911 0.7817166440920572 0.7335508411775561 1.0 14.524381173797813 -6.931066686330135 2.7642626936302044 0.8032898961084881 1.127213549458085 0.7782843679113608 0.07714000533548823 0.11580423678757414 1.7947389723423692 0.029406841820582022 0.024718753702457054 1.1720153876547864e-07 6.931066686330135 0.32392365334959694 GLQTPVKDAGGGT(ph)GR ddPTM_A459_Selumetinib_30min_R2 1 GLQTPVKDAGGGTGR 15 1 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 GLQT(0.052)PVKDAGGGT(0.948)GR 110.22 0.036842 2957300.0 8204.7 10137.0 7702.4 9774.6 11018.0 8481.6 5769.8 6611.0 5752.9 8138.3 True False 7748.715620016415 10914.475304407626 7206.835969739033 8443.282617874502 9633.820337830253 9649.863411701026 6038.107132641801 6630.2369154900325 6903.640749456322 7903.326133157209 0.980437285449711 1.3809977116618781 0.9118737919094396 1.0683201573135122 1.2189577116668662 1.2209876258574834 0.7639956938269112 0.8389172866945066 0.8735108020524601 1.0 12.948244227308722 -7.260982249509803 24.999997833647193 0.8556823816934287 1.1329487401589662 0.47122420925516684 0.13521108859615463 35.37477928444132 1934682.0283797286 0.05296176357147212 0.03850303710089254 5.4829937456266624e-08 7.260982249509803 0.2772663584655375 GLQVDLQS(ph)DGAAAEDIVASEQSLGQK ddPTM_A459_Selumetinib_30min_R1 1 GLQVDLQSDGAAAEDIVASEQSLGQK 26 0 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IS57;A0A3B3IU45 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 GLQVDLQS(1)DGAAAEDIVASEQSLGQK 109.71 1.4975e-08 7832700.0 1573.4 2125.9 2179.0 2518.2 2286.3 2168.3 1908.0 2075.5 1101.9 1662.5 True False 1610.0571586965464 1876.9986396959027 1883.1037683902387 2078.4436424684363 2079.5045686790486 2146.4888706588818 1764.0780238603863 2020.4509978258632 1869.8438204082045 1875.8980691213394 0.8582860578617092 1.0005866899660911 1.0038411997898555 1.107972590132239 1.1085381465598914 1.1442460046159575 0.9403911933694089 1.0770579868298662 0.9967726131751014 1.0 10.873365722766783 -4.58326426624501 1.4531442009413402 1.0556229043917147 0.69959222571927 0.4762511362851125 0.059763854666113544 1.677477638819289 2.284805498713411 0.01741690702863086 0.993819007266579 2.6105723494273248e-05 4.58326426624501 -0.35603067867244464 GLS(ph)APDLR ddPTM_A459_Selumetinib_30min_R1 2 GLSAPDLR 8 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 GLS(1)APDLR;GLS(1)APDLR 122.94 0.0061569 37458000.0 13439.0 14517.4 15107.1 16147.4 16248.5 13524.599999999999 14233.400000000001 13654.8 7470.6 10912.4 True False 13752.102552258093 12817.696059043836 13055.638797360325 13327.559714238287 14778.826043905665 13388.554803354276 13159.76317862392 13292.63034695861 12677.062568964086 12313.112835777261 1.1168664443892424 1.040979338855764 1.0603036755600552 1.0823875239341123 1.2002510040323817 1.0873411932401194 1.0687600571958222 1.0795507622033025 1.0295578979938627 1.0 13.587907910261345 -8.318733458404306 1.3529124510159616 0.9996792957157242 1.095234552618362 0.3862610692344889 0.04051468598455369 0.4775844886303156 1.7665636060816516 0.04123719677823754 0.012796375893277714 4.800279680723768e-09 8.318733458404306 0.09555525690263778 GLS(ph)APDLR ddPTM_A459_Selumetinib_30min_R2 4 GLSAPDLR 8 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 GLS(1)APDLR;GLS(1)APDLR;GLS(1)APDLR;GLS(1)APDLR 117.53 0.0088168 56450000.0 328132.0 319571.0 367944.0 374002.0 393085.0 273143.0 281160.0 299079.0 258704.0 323710.0 True False 309895.73705647094 344081.0681172784 344270.8836271371 323062.28241056326 343702.14807551284 310765.9689047176 294234.49710797094 299949.27037480654 310452.02879371244 314363.6512004122 0.9857874339896476 1.0945319753202665 1.0951357840275833 1.0276706011554928 1.0933266195473625 0.9885556670373413 0.9359685701079716 0.9541474315794346 0.987557014331132 1.0 18.262074887756825 -6.896974197650103 5.40856067986523 0.9651905806740331 1.0611196837690426 0.5918319129235692 0.03586071108432134 0.13657621919071994 6.082529996014498 0.012534991802028153 0.011034825929959663 1.2677271819624946e-07 6.896974197650103 0.09592910309500957 GLS(ph)DHVSLDGQELGTR ddPTM_A459_Selumetinib_30min_R1 1 GLSDHVSLDGQELGTR 16 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 GLS(0.569)DHVS(0.431)LDGQELGTR 91.969 0.012769 0.0 2760.1 2926.1 3209.6 3348.7 3763.9 2721.0 3509.9 2756.6 1176.8 2399.5 True False 2824.4049597803073 2583.5108516930154 2773.7539490708155 2763.912407884224 3423.4559095705176 2693.6292104703284 3245.1454171632995 2683.486013301264 1996.9436499286448 2707.4991981092653 1.043178502786882 0.9542055833283958 1.0244708293940836 1.0208359100583868 1.2644346901233539 0.9948771960307051 1.1985766863493403 0.9911308617100346 0.7375601999524785 1.0 11.402745195207062 -8.008115817766171 24.37612750258681 0.8673018616024367 1.0696525059260176 0.3651702840855059 0.1063239831628939 266.14463791364795 799368.4132862961 0.06112947656960408 0.02715478508120275 9.814861651284797e-09 8.008115817766171 0.20235064432358085 GLS(ph)EDTTEETLK ddPTM_A459_Selumetinib_30min_R2 2 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 1 GLS(0.992)EDT(0.002)T(0.006)EETLK;GLS(0.998)EDT(0.002)TEETLK 169.23 0.00035619 4335400.0 32079.0 28527.0 33167.0 34723.0 34354.0 25995.0 28347.0 36767.0 29740.0 29528.0 True False 30296.177602411626 30714.92917123768 31033.071329499184 29993.66749948397 30038.143391343303 29575.575290884753 29665.19166851489 36873.9858828955 35688.83100502894 28675.449917042395 1.056519695072195 1.071122833646742 1.0822174166151655 1.0459702493336689 1.047521258715841 1.0313901046521121 1.034515299823919 1.2859078406640987 1.2445778918299848 1.0 14.807528501814742 -7.743797220817728 24.999838237356443 1.1989321623852294 1.0533073771437755 0.37559431103376106 0.07162866348044777 194.07046979080565 275008.52006502374 0.03201308535919881 0.018430133295345725 1.803859795841425e-08 7.743797220817728 -0.14562478524145384 GLS(ph)GEEEDDEPDCCNDER ddPTM_A459_Selumetinib_30min_R1 2 GLSGEEEDDEPDCCNDER 18 0 Q6P158;A0A087WW12;A0A087WZ11;Q6P158-3;Q6P158-2 Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 1 GLS(1)GEEEDDEPDCCNDER;GLS(1)GEEEDDEPDCCNDER 334.04 1.6389999999999993e-144 37597000.0 1524.01 1931.02 1833.45 1650.8700000000001 1799.35 1581.5900000000001 2300.1000000000004 1860.1 1255.69 1750.1999999999998 True False 1559.5164677927564 1704.9352806931574 1584.4775604199544 1362.5765451679254 1636.5991102010432 1565.6806405688226 2126.601605178865 1810.7641055436713 2130.814218031018 1974.8552183916802 0.7896864809476134 0.8633216576158199 0.802325935422421 0.6899627539671521 0.8287185283050206 0.7928078099031032 1.0768392464287924 0.9169098011237278 1.0789723713348214 1.0 10.94753117422284 -7.250752655289452 24.61323277351826 1.0112561702975857 0.794763548760254 0.7748861779996113 0.059023488126577685 271.88362470918986 626192.3468129479 0.02240837843652747 0.01716881360284881 5.613676019548751e-08 7.250752655289452 -0.21649262153733173 GLS(ph)GEEEDDEPDCCNDER ddPTM_A459_Selumetinib_30min_R2 2 GLSGEEEDDEPDCCNDER 18 0 Q6P158;A0A087WW12;A0A087WZ11;Q6P158-3;Q6P158-2 Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 1 GLS(1)GEEEDDEPDCCNDER;GLS(1)GEEEDDEPDCCNDER 328.34 4.384599999999997e-144 246480000.0 38506.0 31178.0 39874.0 41942.0 42604.0 32279.0 36944.0 41318.0 33481.0 36435.0 True False 36365.99067173109 33569.25234692915 37308.55025152865 36229.42724601436 37251.7046354075 36725.13925041236 38661.96920314722 41438.22853943689 40178.13553730243 35383.026880501195 1.0277806586347078 0.9487388532445884 1.0544194078570641 1.023921084207174 1.052812829191165 1.0379309654440776 1.0926699214773223 1.171132946861383 1.1355200241346144 1.0 15.110769849813517 -7.208876900798528 2.1869879614401486 1.117285403908345 1.0196068633681103 0.34947016151245125 0.04952695281770722 0.30549092972653474 2.86003986348287 0.023261013884495408 0.015712577382842003 6.181915994823271e-08 7.208876900798528 -0.09767854054023473 GLS(ph)GPCRPPPPPQAR ddPTM_A459_Selumetinib_30min_R1 2 GLSGPCRPPPPPQAR 15 1 Q9UEE5 Q9UEE5 STK17A Serine/threonine-protein kinase 17A 1 GLS(1)GPCRPPPPPQAR;GLS(1)GPCRPPPPPQAR 147.39 0.0015428 14974700.0 5189.5 5733.2 5949.2 6185.9 5955.7 5201.7 5674.0 5417.5 3356.2 4539.6 True False 5310.405252990802 5061.954278707629 5141.331316616429 5105.648688724291 5417.007986564236 5149.375620765716 5246.005611836393 5273.810301479939 5695.226272850546 5122.3018794485615 1.0367224302606879 0.9882186559556249 1.0037150167279707 0.9967488853417473 1.0575339201108156 1.0052854638313642 1.0241500277217455 1.0295781907425745 1.1118490098564167 1.0 12.322576564374039 -8.015175246287226 23.45638789538027 1.0608542124854878 1.0157983239349937 0.19742033617666088 0.03151694693842188 402.47270532050277 622095.4919327952 0.018811334269941925 0.0076481784390444 9.656611372726684e-09 8.015175246287226 -0.04505588855049414 GLS(ph)HSPWAVK ddPTM_A459_Selumetinib_30min_R1 1 GLSHSPWAVK 10 0 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 GLS(0.533)HS(0.467)PWAVK 120.63 0.0050284 28715000.0 5478.0 6962.0 5987.0 6415.3 5888.0 4714.0 6048.7 5942.7 2973.6 5365.6 True False 5605.62674166752 6146.885803454011 5173.998284236967 5294.988285095613 5355.431439610828 4666.581439969545 5592.441689163689 5785.080291389908 5045.982016848927 6054.327025369903 0.9258876697901913 1.0152880374146047 0.8545951123148737 0.8745791667525762 0.8845626305235182 0.7707845017976096 0.9237098798477947 0.9555282143082542 0.8334505215368063 1.0 12.563750889318273 -4.199250327217142 0.001777663959862628 1.790168207090579 1.664422884141994e-05 0.010936991207376234 0.07139167533951822 4056654.3651795466 946.3824970553422 469191.82558968116 483926.96724771924 6.320474343980816e-05 4.199250327217142 -1.7901515628617375 GLS(ph)LEHQK ddPTM_A459_Selumetinib_30min_R2 1 GLSLEHQK 8 0 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 GLS(1)LEHQK 82.831 0.026703 6032300.0 96774.0 103490.0 106210.0 111280.0 98231.0 50410.0 75770.0 78985.0 76615.0 76196.0 True False 91395.68849701622 111427.35022720201 99376.56423270429 96123.4720312927 85890.3435837179 57353.51992358147 79293.45513540668 79214.83327332936 91940.14080196022 73996.02349901655 1.2351432438559475 1.50585592249674 1.3429987117351658 1.2990356438892994 1.1607426929483506 0.775089217116427 1.0715907610421869 1.0705282463507269 1.2425011028218587 1.0 16.17516012282625 -6.314647475255294 2.9640976534435457 1.034689031380132 1.3646917655297026 0.5770222620217447 0.12567346761420242 0.19221070631660767 3.3567702084433595 0.041904103805586235 0.05043025346945198 4.845655386679699e-07 6.314647475255294 0.3300027341495706 GLS(ph)PADVAQEHLK ddPTM_A459_Selumetinib_30min_R2 2 GLSPADVAQEHLK 13 0 P10070 P10070 GLI2 Zinc finger protein GLI2 1 GLS(1)PADVAQEHLK;GLS(1)PADVAQEHLK 173.19 0.00010316 6698600.0 58857.0 56063.0 66172.0 69329.0 65703.0 44691.0 51812.0 51543.0 52423.0 62921.0 True False 55585.96356323888 60362.85182904262 61914.565562626056 59886.27060080427 57448.8017477274 50846.77958549454 54221.36066353033 51692.98159659699 62909.064821003085 61104.307241608745 0.9096897759342869 0.9878657422686361 1.0132602488694213 0.9800662719898238 0.940175976802628 0.8321308575587716 0.8873574239069107 0.8459793413940687 1.029535685140137 1.0 15.898986458727498 -6.523223013250285 24.99841316720602 0.9050363065452002 0.9746259044930474 0.1207252730214965 0.062887101317886 19.14285145520273 1389844.518517537 0.020301917206941064 0.020488385163059966 2.9976228234391046e-07 6.523223013250285 0.06958959794784725 GLS(ph)PAMSPALQR ddPTM_A459_Selumetinib_30min_R2 2 GLSPAMSPALQR 12 0 Q96DF8 Q96DF8 DGCR14 Protein DGCR14 1 GLS(0.892)PAMS(0.108)PALQR;GLS(0.997)PAMS(0.003)PALQR 143.55 0.00081657 5695400.0 43022.0 48257.0 50249.0 56387.0 50033.0 40918.0 37679.0 44097.0 38830.0 43359.0 True False 40631.009470711426 51958.15672928865 47016.03404697452 48706.99332699949 43747.40723930484 46554.083083378435 39431.1481595221 44225.31496934868 46597.085000849846 42107.113009788685 0.9649440810930422 1.23395200989462 1.1165817527324815 1.1567402713094228 1.0389552764905738 1.105610899340355 0.9364486268710822 1.0503050864367636 1.1066321500126919 1.0 15.361776342939578 -6.509460470635922 1.994443544667048 1.0337263384779056 1.1253372738560383 0.1784982342667144 0.07812554412235247 0.5197318244303514 4.15319739278395 0.0279743448436454 0.03057074302789634 3.094136930126039e-07 6.509460470635922 0.0916109353781327 GLS(ph)PAQADSQFLENAK ddPTM_A459_Selumetinib_30min_R2 2 GLSPAQADSQFLENAK 16 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 GLS(1)PAQADSQFLENAK;GLS(1)PAQADSQFLENAK 143.14 0.00039256 4253800.0 20292.6 20760.8 19351.8 18577.8 15092.8 14957.6 18215.5 14039.7 12656.3 16547.699999999997 True False 19164.818529714074 22353.086603506552 18106.726256646736 16047.47159150745 13196.707532656055 17017.873628426147 19062.5568433285 14080.553202602541 15187.913646568515 16069.924904912026 1.1925891778035655 1.3909888649619002 1.1267461648879349 0.9986027742172141 0.8212053018755722 1.058988995227001 1.1862256330458476 0.8762052894409356 0.9451141642812587 1.0 13.972075566834755 -5.541256305206117 3.3657932539119795 0.9841081121693984 1.2906729976782019 0.584553462271842 0.10370933926014295 0.16528498893924518 3.907181306775232 0.029949794436533058 0.06100349135159948 2.8757007771961136e-06 5.541256305206117 0.30656488550880345 GLS(ph)QEGTGPPTSAGEGHSR ddPTM_A459_Selumetinib_30min_R2 1 GLSQEGTGPPTSAGEGHSR 19 0 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4;Q63HN8-5 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 GLS(0.7)QEGT(0.298)GPPTS(0.002)AGEGHSR 86.073 0.0024189 9352300.0 11756.0 11205.0 18529.0 22661.0 22062.0 10223.0 14285.0 19976.0 10454.0 17887.0 True False 11102.648582996691 12064.387470246367 17336.864312849837 19574.532707594568 19290.374323217547 11631.125454845731 14949.280805190505 20034.126852795176 12545.092109165189 17370.555833992712 0.6391648424554006 0.6945308823473213 0.99806042354287 1.1268800431410986 1.1105214195545725 0.6695885592840155 0.860610388525163 1.1533382722037069 0.722204414703616 1.0 14.08435629860149 -5.212529301116619 5.572937178737154 0.9587684506720205 0.6593999663711427 0.35438733160513325 0.15581105405466675 0.23060648653398325 17.096002880761137 0.041192621755944236 0.11132844507759514 6.130144317042069e-06 5.212529301116619 -0.2993684843008778 GLS(ph)QSALPYR ddPTM_A459_Selumetinib_30min_R2 1 GLSQSALPYR 10 0 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 1 GLS(0.978)QS(0.021)ALPYR 113.38 0.005492 0.0 12350.0 13610.0 18208.0 14458.0 20949.0 11703.0 12745.0 13759.0 12114.0 22035.0 True False 11663.6364409671 14653.843236952534 17036.517103371454 12488.795458558863 18317.199333563807 13314.982020743395 13337.667753738398 13799.036412074931 14537.138493440498 21398.792296194417 0.5450605005891559 0.6847976761547702 0.796143860249592 0.5836215093680723 0.8559922018039007 0.6222305369593846 0.6232906777692488 0.6448511776306631 0.679343875683386 1.0 14.385241755733931 -11.616795440125824 2.04916644790294 1.5077358454301852 0.6740271361887338 0.5522840471728943 0.08892802301615518 4178687.3519624732 1089104.749545311 9891262.147422496 0.023178014249050166 2.4165988243788857e-12 11.616795440125824 -0.8337087092414515 GLS(ph)SAGGGSPHREDAQPEHSASAR ddPTM_A459_Selumetinib_30min_R1 1 GLSSAGGGSPHREDAQPEHSASAR 24 1 Q92994-9;Q92994-3;Q92994-7;Q92994-8;Q92994-5;Q92994 Q92994-9 BRF1 Transcription factor IIIB 90 kDa subunit 1 GLS(0.405)S(0.344)AGGGS(0.251)PHREDAQPEHSASAR 57.39 0.0053459 10019000.0 1687.7 1997.3 2364.8 2057.5 2603.6 1931.1 2514.2 1949.0 572.58 1402.4 True False 1727.0201263074628 1763.4551874804208 2043.6731489165838 1698.1962490583787 2368.1048397029144 1911.6748872985117 2324.5518698059664 1897.3061887557726 971.6264404114066 1582.4117005327912 1.0913848309678085 1.1144098510436147 1.2914926932279935 1.0731696741667187 1.4965162598997364 1.2080768150632728 1.4689931002300474 1.1989965620937697 0.614016213406577 1.0 10.627909283363044 -8.163244365661997 6.519605446762896 0.8112141815559301 1.251982701486815 0.5372039450565251 0.16208673846257934 0.1654325707281057 9.06747574747851 0.10931752505273744 0.04044616431685316 6.866819540817557e-09 8.163244365661997 0.44076851993088495 GLS(ph)SAGGGSPHREDAQPEHSASAR ddPTM_A459_Selumetinib_30min_R2 2 GLSSAGGGSPHREDAQPEHSASAR 24 1 Q92994-9;Q92994-3;Q92994-7;Q92994-8;Q92994-5;Q92994 Q92994-9 BRF1 Transcription factor IIIB 90 kDa subunit 1 GLS(0.363)S(0.363)AGGGS(0.273)PHREDAQPEHSASAR;GLS(0.365)S(0.365)AGGGS(0.271)PHREDAQPEHSASAR 48.852 0.020918 9824600.0 18576.5 12811.3 19502.6 26427.2 29823.0 18149.9 18353.6 19929.0 17677.1 21573.9 True False 17544.092497621474 13793.885515177799 18247.823948825353 22827.7697705372 26076.368118997252 20649.88397661201 19207.078766968458 19986.990090576448 21213.013939441735 20951.005451276098 0.8373866609133495 0.6583877583945562 0.8709760489186404 1.0895787232563003 1.2446356419333076 0.9856273497057514 0.9167616710155827 0.9539871552732123 1.012505771561893 1.0 14.354731860932917 -5.554599341853554 4.592851617170859 1.0284383614338304 0.7493225970836203 0.5978320302766156 0.09375507360863305 0.13665184713503647 6.831682380716122 0.02831723158797656 0.05292486434022784 2.7886926892473854e-06 5.554599341853554 -0.2791157643502101 GLSAS(ph)LPDLDSENWIEVK ddPTM_A459_Selumetinib_30min_R1 9 GLSASLPDLDSENWIEVK 18 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0 LARP1 La-related protein 1 1 GLSAS(0.999)LPDLDS(0.001)ENWIEVK;GLS(0.001)AS(0.999)LPDLDSENWIEVK;GLS(0.001)AS(0.98)LPDLDS(0.019)ENWIEVK;GLS(0.004)AS(0.995)LPDLDS(0.002)ENWIEVK;GLS(0.003)AS(0.997)LPDLDSENWIEVK;GLS(0.001)AS(0.998)LPDLDSENWIEVK;GLS(0.004)AS(0.993)LPDLDS(0.002)ENWIEVK;GLS(0.003)AS(0.997)LPDLDSENWIEVK;GLSAS(0.992)LPDLDS(0.008)ENWIEVK 244.97 4.693899999999999e-79 1406485100.0 21459.76 24663.129999999997 26962.800000000003 27903.0 24803.78 22285.38 23111.489999999998 22704.34 14167.92 20706.9 True False 21959.73065457594 21775.559274021914 23301.399856058877 23030.264854180306 22560.282478463025 22061.20931070608 21368.171702132644 22102.147149109936 24041.925456064804 23364.832317286415 0.9398625402643735 0.9319801220191647 0.9972851309024543 0.9856807248362498 0.965565777323035 0.9442057623663811 0.9145441923982246 0.9459578758781725 1.0289791567764621 1.0 14.512051062979964 -8.25762355518566 24.97574172930602 1.0144895817800366 0.9538169351309205 0.5079522287003764 0.02414700039626006 279.04531514693116 1826465.2405996039 0.019727060515360252 0.0068552101206181566 5.525561853747546e-09 8.25762355518566 -0.06067264664911609 GLSAS(ph)LPDLDSENWIEVK ddPTM_A459_Selumetinib_30min_R2 2 GLSASLPDLDSENWIEVK 18 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0 LARP1 La-related protein 1 1 GLS(0.097)AS(0.903)LPDLDSENWIEVK;GLS(0.164)AS(0.813)LPDLDS(0.022)ENWIEVK 166.61 9.49e-08 9359300.0 55303.7 51307.5 57949.9 59488.1 57304.0 41374.8 42798.4 46925.1 40867.9 55112.6 True False 52230.141752252 55242.62027038513 54221.466525080476 51385.71815730359 50104.959215740164 47073.8031369609 44788.610403420724 47061.6442721315 49042.62194453336 53521.356038268386 0.9758747837948434 1.0321603255135394 1.0130809556901268 0.9600974631614754 0.9361675959763527 0.8795330802773866 0.8368362410585477 0.879305902460354 0.9163187477811161 1.0 15.70782704868468 -6.216416212400559 1.7818628589825234 0.8920383049076088 1.008951463107238 0.5177493815823888 0.04258085634296189 0.2500966530895493 1.5667279769421694 0.01462496218726913 0.02008053455142431 6.075524654864978e-07 6.216416212400559 0.11691315819962922 GLSAS(ph)LPDLDSENWIEVKK ddPTM_A459_Selumetinib_30min_R1 2 GLSASLPDLDSENWIEVKK 19 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0 LARP1 La-related protein 1 1 GLS(0.057)AS(0.824)LPDLDS(0.119)ENWIEVKK;GLS(0.073)AS(0.844)LPDLDS(0.083)ENWIEVKK 82.56 0.002599 65076000.0 4914.6 4023.7 9313.099999999999 7956.9 6142.9 5622.0 5092.0 5542.200000000001 3719.6 3831.3 True False 5029.100617853084 3552.6033334326194 8048.43217319648 6567.376784511595 5587.275779617083 5565.447784367579 4707.906340407279 5395.202852397257 6311.889531164671 4323.084675022306 1.163313003538876 0.8217750982206447 1.861733641188731 1.5191413720060223 1.2924280229575316 1.2873788516156839 1.0890155281038965 1.247998421953051 1.4600430030050482 1.0 12.077845378827526 -6.850724958186435 3.158932284720975 1.2178920283669272 1.3447848296253453 0.04713141297054668 0.2704102939781864 1.0450512816856763 20.864934727475365 0.10799543881060289 0.09559438282307484 1.4101815938134452e-07 6.850724958186435 0.12689280125841806 GLSAS(ph)TMDLSSSS ddPTM_A459_Selumetinib_30min_R2 1 GLSASTMDLSSSS 13 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 GLS(0.01)AS(0.895)T(0.095)MDLSSSS 142.08 0.0012396 0.0 19304.0 15249.0 24146.0 22467.0 21466.0 18194.0 15213.0 20176.0 14407.0 15647.0 True False 18231.16096003471 16418.549266736885 22592.472648177027 19406.955842263247 18769.249171525156 20700.058351312073 15920.434643987614 20234.70881968339 17288.802565213584 15195.230454211676 1.1997949629636293 1.0805067627115943 1.4868134258480463 1.277174169930684 1.2352066148705805 1.3622734063618376 1.047725777635372 1.3316486959942695 1.137778240172832 1.0 13.891330934806309 -8.538556735481253 5.108194796495276 1.0000952665101075 1.251341282374616 0.2992986322343658 0.12186139960449378 0.19421217831665905 22.2764600074624 0.11565002196270716 0.030067408171778852 2.8936317733134344e-09 8.538556735481253 0.25124601586450845 GLSAST(ph)MDLSSSS ddPTM_A459_Selumetinib_30min_R1 1 GLSASTMDLSSSS 13 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 GLS(0.013)AS(0.078)T(0.909)MDLSSSS 155.33 0.00085497 4447800.0 2241.9 2582.7 2472.5 3063.1 2790.4 2582.0 2836.4 2543.4 1625.2 2164.7 True False 2294.131908021982 2280.316283335345 2136.7480804703373 2528.1870865082487 2538.008812685132 2556.0274242684263 2622.448064401258 2475.940769872464 2757.845700088403 2442.560330963586 0.9392324434897176 0.9335762373721038 0.8747984864011092 1.0350561476247686 1.0390772258566452 1.0464541619981513 1.0736472017322523 1.013666167621624 1.1290798696466333 1.0 11.25417848169998 -5.835368373177577 6.53319263819055 1.0502837559923122 0.918023764604651 0.7322761491347746 0.03667884960030492 0.098811145356795 6.903761055827128 0.00984316276437698 0.0147924150310813 1.4609374661379544e-06 5.835368373177577 -0.1322599913876612 GLSAST(ph)MDLSSSS ddPTM_A459_Selumetinib_30min_R2 1 GLSASTMDLSSSS 13 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 GLS(0.027)AS(0.255)T(0.717)MDLSSSS 102.4 0.02187 0.0 7380.4 8690.3 12232.0 12977.0 12428.0 6789.4 7558.5 10714.0 8971.4 8069.9 True False 6970.226914082067 9356.8180662813 11445.006437194623 11209.510213426358 10866.683532270317 7724.578221963185 7909.985226883614 10745.175966201821 10765.930681860013 7836.901018881747 0.8894111201976943 1.193943632022091 1.460399513738878 1.430349852118695 1.3866046675961325 0.9856674472922474 1.0093256515331483 1.3711001249490142 1.3737484569374094 1.0 12.936067560361542 -6.736227584652726 24.997466369079632 1.1624967051872344 1.2870454674732952 0.08403352762024952 0.19913783801596122 678.1321876585891 672365.5793412671 0.07136965866354682 0.07134350492877103 1.835576188720267e-07 6.736227584652726 0.12454876228606082 GLSDHVS(ph)LDGQELGTR ddPTM_A459_Selumetinib_30min_R1 1 GLSDHVSLDGQELGTR 16 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 GLSDHVS(1)LDGQELGTR 115.26 0.0022196 0.0 1183.4 1572.1 1696.5 1575.2 1642.0 1316.3 1531.9 1335.6 728.97 1150.1 True False 1210.9709175044443 1388.0378011505388 1466.1246182074515 1300.1208901661037 1493.481389918646 1303.0592171047747 1416.347549660234 1300.1755493597798 1237.0088481377338 1297.7265379226778 0.9331479954497142 1.0695919059900136 1.1297639181782744 1.0018450360483948 1.1508444547256627 1.0041092472306477 1.0914067858452194 1.0018871552407507 0.9532122615893043 1.0 10.341770689611185 -7.937157080964064 5.782108401332444 0.9766853337731445 1.0574024715066646 0.21659476767205055 0.0614469404011426 0.2682966152874761 17.1968872334794 0.03347498598908818 0.015586153441066829 1.1556941609250052e-08 7.937157080964064 0.08071713773352007 GLSDHVS(ph)LDGQELGTR ddPTM_A459_Selumetinib_30min_R2 3 GLSDHVSLDGQELGTR 16 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 GLSDHVS(1)LDGQELGTR;GLSDHVS(1)LDGQELGTR;GLS(0.019)DHVS(0.981)LDGQELGTR 201.75 5.5736e-07 61867300.0 96530.0 90655.0 116556.0 134666.0 132815.0 96460.0 90956.0 87170.0 80017.0 111360.0 True False 91165.24904020676 97607.9469982318 109056.91385657742 116324.25848819263 116129.59231883509 109746.4894233024 95185.63422589471 87423.65026822961 96022.63586178211 108144.74745197233 0.8429928516009874 0.9025676169948061 1.0084346806118363 1.0756348433829657 1.0738347913791084 1.01481109354887 0.8801688151166766 0.8083947887256838 0.887908457176122 1.0 16.722604070305223 -7.26993898552545 23.100436319074287 0.8781508845794588 0.9916045254595276 0.22989173502360238 0.08029328432166016 310.66446525287665 844323.6022347576 0.0362122954248604 0.02491555607389319 5.371072498149997e-08 7.26993898552545 0.11345364088006882 GLSDHVSLDGQELGT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GLSDHVSLDGQELGTR 16 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 GLSDHVS(0.092)LDGQELGT(0.908)R 155.26 0.00021614 23757000.0 1160.3 1285.1 1402.6 1494.2 1391.1 1363.8 1318.9 1159.6 661.76 1068.4 True False 1187.3327324492202 1134.6398945732185 1212.1346239303116 1233.2660196077907 1265.2752506186525 1350.0814102313238 1219.4143111475178 1128.84364108835 1122.9583869619144 1205.5395470972862 0.9848973725566245 0.9411884473680014 1.005470643289061 1.0229992226943236 1.049551011134557 1.1198980684474993 1.0115091737003894 0.9363804313233809 0.9314985888814582 1.0 10.235463263238616 -7.704887717511202 6.492673510762037 0.9505809252059817 1.0213857771931263 0.2794000341301677 0.04645471670499507 0.2678483605471622 23.06288771913371 0.025234695676141304 0.014231128697028746 1.9729327521862196e-08 7.704887717511202 0.07080485198714459 GLSEDTTEETLK ddPTM_A459_Selumetinib_30min_R1 1 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 152.54 0.0068295000000000005 5867100.0 775.17 741.74 681.02 913.0 827.62 634.38 818.1 659.21 588.25 759.64 False True 793.2299527817477 654.8967359744291 588.5412245750897 753.5616891325881 752.7619171281783 627.9987131709548 756.3900583439109 641.7256093841429 998.2172859198896 857.1471935202005 0.9254302630614091 0.7640423265983605 0.6866279549467129 0.8791508562698558 0.8782177936518413 0.7326614587534722 0.8824506036559577 0.7486760899824603 1.1645809418337254 1.0 9.743399162055614 -8.258817818114842 24.9999521358219 1.0822904838846104 0.8104974310845948 0.6298161018632643 0.08283215658261833 132.03635660801294 1259168.643830868 0.06019331543791792 0.02035968736546683 5.510388028064767e-09 8.258817818114842 -0.27179305280001553 GLSEDTTEETLK ddPTM_A459_Selumetinib_30min_R2 2 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 ; 205.53 0.00020787 13288700.0 87652.0 81438.0 89235.0 89475.0 90904.0 81535.0 78594.0 86725.0 78550.0 85266.0 False True 82780.65273875682 87684.03273555766 83493.71725172208 77288.35064701598 79483.82682792904 92765.70614896277 82248.77673105654 86977.35539190326 94262.19487037748 82804.14903232646 0.999716242557357 1.0589328404465108 1.0083277012982335 0.9333874153678322 0.9599014995842639 1.1203026325739711 0.9932929411417162 1.0503985175664035 1.1383752622538013 1.0 16.33741543759284 -6.746114058668226 24.999618194160643 1.0594249851866926 0.9934136174384965 0.3005171557781887 0.052159976231771286 339.8181437396299 554331.3403276077 0.017826796558957487 0.01776354648581593 1.794262338208394e-07 6.746114058668226 -0.06601136774819605 GLSEDTTEETLKESFDGSVR ddPTM_A459_Selumetinib_30min_R1 2 GLSEDTTEETLKESFDGSVR 20 1 P19338;H7BY16 P19338 NCL Nucleolin 0 ; 242.67 7.1596e-30 44134000.0 4435.4 5677.5 7263.5 7562.0 6288.3 6122.3 5812.2 5981.7 3638.5 4207.3 False True 4538.736190213969 5012.775660601858 6277.156595549558 6241.438656320519 5719.5243752895385 6060.715220603637 5373.781074570933 5823.045884700055 6174.268754474315 4747.3479375724555 0.9560572028632139 1.0559107372199747 1.3222448992772513 1.314721132387036 1.2047830600371379 1.2766528386589606 1.1319543343433138 1.2265892370378175 1.3005722006614733 1.0 12.212906074773866 -5.070059093285973 4.542881134998036 1.2310885372501579 0.9744631872029381 0.4740411978365029 0.09324029975015877 0.15321217237425244 5.954755388860002 0.022899461900790993 0.07117229740951286 8.510222340098593e-06 5.070059093285973 -0.25662535004721976 GLSHS(ph)PWAVK ddPTM_A459_Selumetinib_30min_R2 1 GLSHSPWAVK 10 0 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 GLS(0.021)HS(0.979)PWAVK 91.549 0.027875 18730000.0 60001.0 53810.0 50431.0 64994.0 67446.0 50558.0 53569.0 53056.0 39990.0 48440.0 True False 56666.38462303373 57937.05397357942 47186.32436512117 56141.70507909631 58972.830505109734 57521.90558017126 56060.06464495976 53210.38417610637 47989.1174139579 47041.41133776527 1.2046063885320006 1.2316181068119236 1.003080541659675 1.1934528213022648 1.2536365051140763 1.2227929380594955 1.1917173199256086 1.1311391955068446 1.0201462083989774 1.0 15.521643724150824 -8.177954006815272 2.4603675944944965 0.9996494349517752 1.1846828944330376 0.5349139082437002 0.06483604048395962 0.24965954848823807 2.703474666433113 0.061539914396085076 0.018574742569395102 6.638133666535699e-09 8.177954006815272 0.18503345948126249 GLSLVDKENT(ph)PPALSGTR ddPTM_A459_Selumetinib_30min_R1 1 GLSLVDKENTPPALSGTR 18 1 P31350-2;P31350;A0A286YFD6 P31350-2 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 GLS(0.026)LVDKENT(0.778)PPALS(0.116)GT(0.08)R 71.946 0.028729 126000000.0 1724.8 2448.6 1633.3 1841.2 1801.6 1897.4 1753.5 1718.9 1285.5 1802.6 True False 1764.9844841234294 2161.916773676744 1411.5068310747017 1519.6689836045143 1638.6455980983148 1878.3138787013604 1621.23208324905 1673.3091882259112 2181.39961079476 2033.9812688109018 0.8677486421274999 1.0628990575417812 0.6939625515331768 0.7471401073879786 0.8056345568296671 0.9234666550294501 0.7970732612482947 0.82267679348107 1.0724777284060445 1.0 10.990090677958753 -8.258031575653236 24.96115816446676 1.0362388773281364 0.8397326981235241 0.3974931033649912 0.09660318177103054 285.3157426429581 2089896.0227121538 0.07469647372290823 0.02565858790375925 5.520373016027205e-09 8.258031575653236 -0.19650617920461222 GLSLVDKENT(ph)PPALSGTR ddPTM_A459_Selumetinib_30min_R2 1 GLSLVDKENTPPALSGTR 18 1 P31350-2;P31350;A0A286YFD6 P31350-2 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 GLS(0.001)LVDKENT(0.999)PPALSGTR 124.45 0.0089689 5286500.0 16016.0 16432.0 18025.0 20470.0 18404.0 16101.0 18414.0 16287.0 11567.0 18699.0 True False 15125.894837127846 17692.281562792352 16865.291124136125 17681.950687280387 16091.92498615247 18318.766599674378 19270.28748664879 16334.392473541993 13880.723208983523 18159.111284163355 0.8329644882081432 0.9742922594577562 0.9287509096793973 0.9737233508063193 0.8861625844094205 1.0087920225286717 1.0611911114534827 0.8995149717369314 0.7643944129076937 1.0 14.148405977701174 -4.75217688426451 24.796859245179434 0.9452687442443104 0.8329642441955681 0.1546254076608201 0.07790767267744061 676.3678908190367 1810577.2634484346 0.01989636225899927 0.2429010627037316 1.7693881555428592e-05 4.75217688426451 -0.11230450004874226 GLSQNQQIPQNS(ph)VTPR ddPTM_A459_Selumetinib_30min_R2 1 GLSQNQQIPQNSVTPR 16 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 GLSQNQQIPQNS(0.934)VT(0.066)PR 143.88 0.00039066 7675300.0 29081.0 24558.0 28296.0 27378.0 27045.0 20750.0 20052.0 24605.0 21537.0 30532.0 True False 27464.794440466725 26441.519633584157 26475.46616635537 23649.06917031572 23647.365314632345 23608.124150254243 20984.457732284205 24676.596476422972 25845.001794058793 29650.461828337116 0.9262855533069122 0.8917742929829796 0.8929191835067006 0.7975953058415491 0.7975378411149205 0.7962143823234424 0.7077278544184171 0.8322499871769082 0.8716559608308893 1.0 14.85576695556062 -5.700851101817999 5.753683828450217 0.8143131700051677 0.90427185871965 0.16725219268909886 0.07144980755234527 0.2855647744014631 18.567183215975124 0.01899668466576287 0.03295188578020994 1.9913559598149504e-06 5.700851101817999 0.08995868871448232 GLSQNQQIPQNSVT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GLSQNQQIPQNSVTPR 16 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 GLSQNQQIPQNSVT(1)PR 265.6 1.5565e-39 7841400.0 26007.0 28879.0 27893.0 29470.0 31843.0 23301.0 23807.0 27108.0 25214.0 28366.0 True False 24561.635054269722 31093.92643937928 26098.394747602157 25456.135161414422 27842.597659968123 26510.501244581876 24914.072672675542 27186.87979202901 30257.504538022862 27546.999876280956 0.8916264988775874 1.1287590873426607 0.947413325037762 0.9240982784238929 1.0107306706724781 0.9623734476946963 0.9044205461418516 0.9869270669811843 1.0983956392316885 1.0 14.749607584033832 -8.07064947362655 8.429780235427227 1.04769796938049 0.9704956089464254 0.18834538188423366 0.06697116070914662 0.6280573889038056 69.35448160014481 0.04430967621066111 0.016708790142901202 8.498661395342666e-09 8.07064947362655 -0.07720236043406459 GLSSAGGGS(ph)PHREDAQPEHSASAR ddPTM_A459_Selumetinib_30min_R2 1 GLSSAGGGSPHREDAQPEHSASAR 24 1 Q92994-9;Q92994-3;Q92994-7;Q92994-8;Q92994-5;Q92994 Q92994-9 BRF1 Transcription factor IIIB 90 kDa subunit 1 GLS(0.244)S(0.244)AGGGS(0.512)PHREDAQPEHSASAR 53.278 0.009042200000000002 27263000.0 21133.0 15273.0 24779.0 34467.0 30632.0 18265.0 16817.0 19775.0 19836.0 26974.0 True False 19958.512462101826 16444.389989564723 23184.74611733531 29772.53514110862 26783.734306445487 20780.837956838248 17599.023822253315 19832.54197607252 23803.754264147752 26195.190533131296 0.7619151476244691 0.6277637098598728 0.8850764451593349 1.1365649394094977 1.0224676271229947 0.7933073794807847 0.6718417947750495 0.757106231046062 0.9087070481140845 1.0 14.677014335169858 -12.716702086950272 0.01492841951726937 1.891172470326875 2.8340430221204226e-06 0.06960551693967798 0.14922914691264577 19528.0629891903 30.35183175680093 2261.0546132176105 1628.7876182823145 1.9199853416718317e-13 12.716702086950272 -1.891169636283853 GLSTS(ph)LPDLDSEPWIEVK ddPTM_A459_Selumetinib_30min_R2 1 GLSTSLPDLDSEPWIEVK 18 0 A0A3B3ISF0;Q659C4-2;Q659C4;H0Y9K3;D6R9W6;D6RJB0;Q659C4-9;Q659C4-4 A0A3B3ISF0 LARP1B La-related protein 1B 1 GLS(0.009)T(0.046)S(0.945)LPDLDSEPWIEVK 124.46 0.00086535 9778800.0 18004.0 14194.0 13931.0 16066.0 13859.0 11319.0 11282.0 12848.0 9992.2 12913.0 True False 17003.40975572239 15282.63415909656 13034.694626925948 13877.783084604138 12117.908518968005 12878.089506348319 11806.635354858892 12885.385552899095 11990.919205395096 12540.168137996758 1.3559156120245304 1.2186945175631354 1.0394353954019782 1.1066664283833965 0.9663274356147343 1.0269471162294592 0.9415053470523048 1.0275289303224195 0.9562008318742206 1.0 13.614269071407735 -4.0137252270691395 0.6574719478541073 0.983658221673104 2.1824508461675682 0.8988350506960955 0.039539059563485364 2.094861076672948 0.32697755605735557 0.015766266402996592 2.3698700270771464 9.688906679332686e-05 4.0137252270691395 1.1987926244944642 GLT(ph)SVINQK ddPTM_A459_Selumetinib_30min_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 GLT(0.5)S(0.5)VINQK 123.11 0.013402 18071000.0 3001.7 5856.7 5343.4 5907.2 4950.3 4378.0 5273.7 4781.5 2140.7 3849.5 True False 3071.6337697085423 5170.994841294039 4617.795629195224 4875.618411877355 4502.546239046453 4333.961294905953 4875.900563119773 4654.679087499094 3632.611549458065 4343.620822305321 0.7071597396197931 1.190480258944334 1.0631212571507078 1.1224779075650724 1.0365882343884667 0.9977761577737715 1.1225428651785383 1.0716126655430946 0.8363095440568643 1.0 12.08468245280069 -10.222586793559607 8.056697126772216 0.9999999871152866 1.0308472128589976 0.0 0.13738106174585737 0.0 0.0 0.12598849719709226 0.030556698915085063 5.989812205176646e-11 10.222586793559607 0.030847225743711015 GLTLAPGLS(ph)PARPLFGSDFEK ddPTM_A459_Selumetinib_30min_R1 2 GLTLAPGLSPARPLFGSDFEK 21 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 GLTLAPGLS(1)PARPLFGSDFEK;GLTLAPGLS(1)PARPLFGSDFEK 113.51 4.739300000000001e-05 121486000.0 11403.6 14671.400000000001 12011.0 12876.0 13262.8 11564.7 13831.599999999999 13344.3 6964.200000000001 11460.2 True False 11669.28169245706 12953.66566745119 10379.972171700389 10627.44831245477 12063.182081737517 11448.369617907469 12788.271276114952 12990.365815604753 11817.738754956725 12931.228301801137 0.9024109249414222 1.001735130269638 0.8027058164501362 0.821843684483903 0.9328720984732198 0.8853273139035736 0.9889448223827065 1.0045732325207946 0.913891432363829 1.0 13.658571698839362 -7.258947396892772 24.814282044519146 0.977233476866053 0.8909018899720338 0.35396648066536873 0.056720164344988 241.35691812389086 2403361.4114300422 0.023509174166338707 0.01733880192646844 5.508744159984836e-08 7.258947396892772 -0.08633158689401921 GLTPS(ph)QIGVILR ddPTM_A459_Selumetinib_30min_R2 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 1 GLT(0.318)PS(0.682)QIGVILR 77.192 0.04632 2809800.0 16026.0 15961.0 19442.0 13811.0 20671.0 12407.0 14734.0 14654.0 14934.0 15123.0 True False 15135.339077161032 17185.157377296066 18191.12288684906 11929.917974696114 18074.12417891534 14115.95163046768 15419.16019486713 14696.64071389971 17921.21729082387 14686.359695727173 1.0305711824261314 1.1701441155833796 1.2386407022389325 0.8123128005755563 1.23067421426249 0.9611606907989972 1.0498966738063182 1.000700038565413 1.220262724195557 1.0 13.842189219299653 GLTS(ph)VINQK ddPTM_A459_Selumetinib_30min_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 GLT(0.001)S(0.999)VINQK 139.15 0.0024046 18174000.0 2514.2 5682.2 5042.7 6258.7 4194.5 3884.6 4693.6 4536.0 1506.7 3050.4 True False 2572.775968218415 5016.925382416888 4357.929037568358 5165.735535349537 3815.1082155991216 3845.524450934597 4339.557973160962 4415.6905449954775 2556.759854985969 3441.9485534121713 0.7474765901622489 1.4575829082173135 1.2661226540553985 1.5008171839839068 1.1084152352646348 1.1172521585548805 1.2607852516734879 1.2829042841497407 0.7428233790569961 1.0 11.749009818329622 -8.253847766986025 24.82301673221869 0.8714116817740989 1.2311681478880399 0.3099555817040034 0.20586948848450534 530.2946340617508 1733969.969362561 0.13977690207565213 0.050536318002406426 5.5738109319139615e-09 8.253847766986025 0.35975646611394096 GLTS(ph)VINQK ddPTM_A459_Selumetinib_30min_R2 4 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 GLT(0.002)S(0.998)VINQK;GLT(0.005)S(0.995)VINQK;GLT(0.001)S(0.999)VINQK;GLT(0.001)S(0.999)VINQK 120.63 0.0065183 26363000.0 214634.0 248482.0 267609.0 226534.0 273987.0 164302.0 185998.0 201220.0 170768.0 248245.0 True False 202705.50152797814 267539.77040444064 250391.32829064917 195679.67840705282 239566.303585142 186933.1091149434 194647.27554804506 201805.5168862358 204926.37165658324 241077.5218320304 0.8408311981455169 1.1097665529797824 1.038634072508461 0.8116877795989279 0.9937314012712419 0.7754066314203616 0.8074053278333623 0.8370980228793077 0.8500434636098703 1.0 17.87913761416504 -5.75732488204199 24.99652115680627 0.8599899657944021 1.0077462253653076 0.27423383614298213 0.09465093686932936 117.62378303975798 714578.9605837554 0.025211110294964954 0.041728264998772746 1.7485381728458253e-06 5.75732488204199 0.14775625957090543 GLVAAYS(ph)GESDSEEEQER ddPTM_A459_Selumetinib_30min_R2 1 GLVAAYSGESDSEEEQER 18 0 P98175-5;P98175-2;P98175;P98175-4;P98175-3 P98175-5 RBM10 RNA-binding protein 10 1 GLVAAYS(0.59)GES(0.41)DS(0.001)EEEQER 145.46 0.00026901 2914900.0 11734.0 11841.0 13357.0 16608.0 19475.0 11516.0 11903.0 12188.0 9402.1 14636.0 True False 11081.871254923713 12749.16662518405 12497.625162002014 14345.961749602 17028.376391291 13102.22446816038 12456.513085347053 12223.46506216798 11282.782716623493 14213.420651105132 0.7796765836281688 0.8969808843441757 0.8792834229549302 1.0093250669033398 1.1980491402656823 0.9218206362689791 0.8763909400217832 0.8599946038477072 0.7938119185789542 1.0 13.79496617990822 -10.607678081755472 12.079857415882286 0.9999999832046679 0.9202307139098713 0.047017624053785845 0.11341434428888643 0.0 0.0 0.1201141267570326 0.029131954808710236 2.467867952110548e-11 10.607678081755472 -0.07976926929479655 GLVAAYSGDS(ph)DNEEELVER ddPTM_A459_Selumetinib_30min_R1 3 GLVAAYSGDSDNEEELVER 19 0 P52756 P52756 RBM5 RNA-binding protein 5 1 GLVAAYS(0.001)GDS(0.999)DNEEELVER;GLVAAYSGDS(1)DNEEELVER;GLVAAYSGDS(1)DNEEELVER 306.4 3.023799999999999e-101 35611000.0 2947.52 3262.41 2962.57 3263.1 3728.35 2673.37 2931.17 3003.3900000000003 1747.84 2614.55 True False 3016.19148112447 2880.4455205467375 2560.2692662321574 2693.2608409732175 3391.1214007936574 2646.4783250257483 2710.0694870014936 2923.73034081437 2965.9568228172034 2950.152960373653 1.022384778564991 0.9763715845370653 0.8678428883592142 0.9129224406832456 1.1494730769363746 0.8970647829360541 0.9186199913709723 0.991043644206185 1.0053569637425 1.0 11.526574042340501 -7.981470909047539 24.32627056069143 1.0011857951150367 0.9624063171778956 0.045537577873062896 0.07508853202438273 615.1660913352415 807631.9393184541 0.042563900538792436 0.020439428077676423 1.0435880344989644e-08 7.981470909047539 -0.038779477937141094 GLVAAYSGDS(ph)DNEEELVER ddPTM_A459_Selumetinib_30min_R2 4 GLVAAYSGDSDNEEELVER 19 0 P52756 P52756 RBM5 RNA-binding protein 5 1 GLVAAYS(0.026)GDS(0.974)DNEEELVER;GLVAAY(0.001)S(0.011)GDS(0.988)DNEEELVER;GLVAAYS(0.01)GDS(0.99)DNEEELVER;GLVAAYS(0.125)GDS(0.875)DNEEELVER 241.92 5.9632e-30 21398700.0 71604.0 66714.1 83241.9 84884.7 94111.3 62908.2 63712.5 73701.4 63826.2 72901.8 True False 67624.53633352298 71830.85695035805 77886.20678092801 73323.25742572483 82288.19712830326 71573.23352621803 66675.25749392368 73915.85887207634 76593.22345303214 70796.93561237608 0.9551901611077849 1.0146040408251968 1.1001352827948199 1.0356840559763878 1.1623129788956343 1.0109651343963855 0.9417816875433817 1.0440544951942106 1.0818720159357125 1.0 16.1113992953308 -4.879978385914478 3.7704489304889517 1.0478651793339957 0.954125964082017 0.19565912332205726 0.0567270654102744 0.4068463086083981 9.779510229449368 0.015048939442237617 0.0874591924586922 1.3183223475477902e-05 4.879978385914478 -0.0937392152519787 GLVAAYSGES(ph)DSEEEQER ddPTM_A459_Selumetinib_30min_R2 1 GLVAAYSGESDSEEEQER 18 0 P98175-5;P98175-2;P98175;P98175-4;P98175-3 P98175-5 RBM10 RNA-binding protein 10 1 GLVAAYS(0.009)GES(0.645)DS(0.346)EEEQER 184.22 4.7533e-10 2789900.0 10507.0 7804.0 12864.0 13685.0 9845.3 8131.5 7000.1 7826.1 7536.9 10551.0 True False 9923.063002853547 8402.541706184978 12036.344245264188 11821.07939205824 8608.445395901264 9251.540314592397 7325.618520435002 7848.872655319397 9044.490598581127 10246.365215209767 0.968447131683701 0.8200509673139694 1.1746940493002693 1.1536851501751038 0.8401462582187521 0.9029094825606405 0.7149480197681036 0.7660153127929192 0.8827023445499903 1.0 13.322824599915595 -6.33269195486521 10.890734945917767 0.8350347805640581 1.0246148925654959 0.35141232328395766 0.11725413726400084 0.8489419513662664 127.60691621410372 0.038417007055028096 0.04356232532853027 4.6484487284833295e-07 6.33269195486521 0.18958011200143776 GLVGEIIKR ddPTM_A459_Selumetinib_30min_R1 1 GLVGEIIKR 9 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 93.143 0.033769 9816900.0 4692.2 5050.2 6233.2 6253.3 5969.1 5280.8 5689.9 5356.2 3796.5 4173.8 False True 4801.519130568151 4458.920236225716 5386.765676516762 5161.278543978986 5429.195958930201 5227.679946582766 5260.706262035227 5214.136176610403 6442.383214610896 4709.547886254828 1.0195286780248585 0.9467830764051496 1.1437967734097036 1.0959180517184182 1.1528061907546838 1.1100173674505245 1.117029997165757 1.1071415563749238 1.367940908598356 1.0 12.201372853297286 -5.2686168743309265 24.2808085177189 1.138102353623369 0.9831558731646504 0.3241296845976809 0.08874881039646738 369.45299525096044 1249831.1034190215 0.022199896991060966 0.04783898499921724 5.387448425726241e-06 5.2686168743309265 -0.15494648045871862 GLVGPELHDR ddPTM_A459_Selumetinib_30min_R1 2 GLVGPELHDR 10 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 133.23 0.0032409 11699900.0 7453.2 8956.9 9372.2 8989.5 8747.599999999999 7776.9 8134.4 7857.5 4450.0 6873.7 False True 7626.845058597364 7908.221984050161 8099.506717809538 7419.652578814235 7956.381124514217 7698.671446860231 7520.815658956991 7649.093575242941 7551.324984859338 7756.0063505078815 0.9833469331930008 1.0196255168785817 1.0442883040289366 0.9566331232217699 1.0258347872540376 0.992607677062578 0.9696763152423812 0.9862154863684531 0.9736099538346638 1.0 12.921098269365492 -6.996640454394547 24.78438755010701 0.9812146228549815 1.0064087724565343 0.18166988887631264 0.023590755704271178 146.06699500174622 1077564.7673632652 0.008186740787105164 0.007184676439427252 1.0077656369902956e-07 6.996640454394547 0.02519414960155275 GLVLDHGAR ddPTM_A459_Selumetinib_30min_R1 2 GLVLDHGAR 9 0 P40227;P40227-2 P40227 CCT6A T-complex protein 1 subunit zeta 0 ; 141.52 0.0030901999999999995 12847200.0 9878.2 10388.099999999999 8923.8 10564.4 8742.3 8200.8 8499.7 8831.3 6039.5 7675.9 False True 10108.342840368767 9171.85642270333 7711.996974924643 8719.525858348647 7951.560508578425 8118.307397730638 7858.56078585227 8597.065235894748 10248.590392372575 8661.176534597591 1.1670865730527928 1.058961953502021 0.8904098587667169 1.006736881937226 0.9180693265880724 0.9373215480947156 0.9073317873686993 0.9925978533693723 1.1832792405782244 1.0 13.080347298683144 -11.120378155126748 12.55434805515279 1.00000002685395 0.9969651258647161 0.0 0.09837809049107268 7.629365499025457e-08 2.448948563701969e-09 0.0982495520983392 0.02382880561014647 7.579173429567234e-12 11.120378155126748 -0.0030349009892338685 GLVLDHGAR ddPTM_A459_Selumetinib_30min_R2 3 GLVLDHGAR 9 0 P40227;P40227-2 P40227 CCT6A T-complex protein 1 subunit zeta 0 ;; 180.87 0.001339 10244400.0 109045.0 109383.0 107200.0 126982.0 128652.0 92897.0 108167.0 102082.0 96060.0 103346.0 False True 102984.71544172113 117772.32437822032 100302.86871053508 109686.83254383213 112489.5855965272 105692.71851499591 113196.97982884418 102379.04171941523 115274.68414065494 100362.13245484493 1.0261312003115932 1.173473714612517 0.999409500945623 1.0929105416645326 1.120836941633725 1.0531135193101773 1.1278853593487954 1.0200963173583197 1.1485874335374398 1.0 16.61485550443509 -10.674671808514272 5.343429454364751 0.999997517888274 1.0845605729718357 0.1720729863656134 0.055746725229286524 1.492574820939786e-06 2.368822758301916e-07 0.048873114109772506 0.011853123327061201 2.1150867835033968e-11 10.674671808514272 0.08456305508356177 GLVTPRMAEVAS(ph)RDPK ddPTM_A459_Selumetinib_30min_R1 1 GLVTPRMAEVASRDPK 16 2 P48736 P48736 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1 GLVTPRMAEVAS(1)RDPK 81.44800000000002 0.024384 8601600.0 2891.2 3807.0 3450.1 3865.9 3390.8 2968.8 2816.2 3191.3 1458.3 2583.4 True False 2958.559334704115 3361.2746701737155 2981.595370042754 3190.7931369306375 3084.1027386943642 2938.9365674547253 2603.771766664371 3106.656357196665 2474.6285899821073 2915.004554446957 1.0149415822320802 1.1530941401261123 1.0228441549067941 1.0946100005445802 1.0580095780603296 1.0082099401770261 0.893230771352385 1.0657466563670837 0.8489278640086382 1.0 11.50928242217805 -6.891293513992415 3.1178137430486332 0.9565252718418206 1.0731456141274514 0.41277177471173576 0.06527753160570379 0.24087259628719776 4.676745624406772 0.022935632041189737 0.019879267031851038 1.284418304062947e-07 6.891293513992415 0.11662034228563078 GLWSTDS(ph)AEEDKETK ddPTM_A459_Selumetinib_30min_R1 2 GLWSTDSAEEDKETK 15 1 Q99549-2;Q99549;A0A0A0MT47 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GLWS(0.001)T(0.327)DS(0.672)AEEDKETK;GLWS(0.057)T(0.25)DS(0.689)AEEDKET(0.005)K 174.24 0.0001277 44957000.0 3368.6000000000004 4432.0 4844.0 5356.6 3262.8 4545.1 4051.3 3618.2 2590.8999999999996 3804.2 True False 3447.081825845422 3913.0993796191 4186.211406187386 4421.1703658352935 2967.680316094128 4499.380420620613 3745.707179279658 3522.2335824300353 4396.568068151027 4292.506126045957 0.8030464545942774 0.9116118334404458 0.9752371419545337 1.0299741540282565 0.6913630939480586 1.0481942922153074 0.8726154533715289 0.8205541189697827 1.024242700895322 1.0 12.067604477831795 -8.285736022862045 24.455030790400496 1.0121214152384452 0.8995595170447592 0.173732522623247 0.10241818828348086 1245.6426175938159 1253746.971447729 0.09548000056141655 0.024707820609123625 5.179215444556186e-09 8.285736022862045 -0.112561898193686 GLWSTDS(ph)AEEDKETK ddPTM_A459_Selumetinib_30min_R2 3 GLWSTDSAEEDKETK 15 1 Q99549-2;Q99549;A0A0A0MT47 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GLWS(0.166)T(0.166)DS(0.669)AEEDKETK;GLWS(0.001)T(0.014)DS(0.985)AEEDKETK;GLWS(0.049)T(0.073)DS(0.879)AEEDKETK 108.96 0.0021254 82217900.0 228544.0 176943.0 181881.0 188657.0 140705.0 133058.0 187868.0 179721.0 117439.0 141790.0 True False 215842.43941412028 190513.9591385815 170178.97447706017 162961.59114852283 123028.37998134004 151385.5317197362 196604.2342533797 180243.95835558663 140930.08151982518 137696.15428533754 1.5675269983709639 1.383582280328567 1.2359021597975124 1.1834868736481166 0.8934772406671391 1.0994172822432728 1.4278120930376261 1.308997766067456 1.0234859662658857 1.0 17.071128741455446 -5.039177452527273 1.5701814640308578 1.1493216108900748 1.615920667656325 0.48162966726963774 0.14539652993323604 0.654716932549719 2.1958827669720717 0.0458244748390692 0.4063235465729511 9.137398115134598e-06 5.039177452527273 0.46659905676625013 GLYDGPVCEVS(ph)VTPK ddPTM_A459_Selumetinib_30min_R2 1 GLYDGPVCEVSVTPK 15 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 GLYDGPVCEVS(0.935)VT(0.065)PK 128.74 0.0009437 77921000.0 364200.0 325420.0 326110.0 302720.0 297450.0 267490.0 333950.0 297620.0 217090.0 313120.0 True False 343959.22200811503 350378.6676097785 305128.43764172215 261489.01377887293 260081.6717632608 304334.31946754246 349479.3367093714 298486.0249263568 260514.06600140332 304079.41201653704 1.1311493261813108 1.1522604088392658 1.0034498410077433 0.8599365936837977 0.8553083881559088 1.0008382923701244 1.1493028560919651 0.981605505439888 0.8567303661690702 1.0 18.2140886150833 -5.343923757431849 4.257379271062657 0.9607445045745715 1.1423422040096094 0.4203951724759709 0.08480971878875568 0.2261830621040863 7.463062387809387 0.025085659587826627 0.056762172322255944 4.529770953181176e-06 5.343923757431849 0.1815976994350379 GLYDGPVCEVSVT(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 GLYDGPVCEVSVTPK 15 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 GLYDGPVCEVS(0.001)VT(0.999)PK;GLYDGPVCEVS(0.12)VT(0.88)PK;GLYDGPVCEVS(0.051)VT(0.949)PK;GLYDGPVCEVS(0.08)VT(0.92)PK 220.34 4.964399999999999e-09 957406000.0 10890.199999999999 11812.0 14683.4 14799.7 10876.399999999998 10204.9 11382.599999999999 11022.5 7457.9 10680.4 True False 11143.920471359555 10429.045548750184 12689.474930142824 12215.210219776085 9892.631540384378 10102.24797130785 10524.001317816164 10730.147493874045 12655.511596535385 12051.333375905893 0.9247043562531828 0.865385200412833 1.0529519460072991 1.0135982333870066 0.8208744403472079 0.838268070112903 0.8732644753531332 0.8903701490265565 1.050133723944391 1.0 13.556905156576077 -8.259820445544625 24.984703557248004 1.0250668701148915 0.9100864310071669 0.3001606919863029 0.0703243022992674 190.59895361783416 2941606.805028881 0.05956626841160761 0.019703962459467855 5.497681226871367e-09 8.259820445544625 -0.1149804391077246 GLYDGPVCEVSVT(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 GLYDGPVCEVSVTPK 15 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 GLYDGPVCEVS(0.309)VT(0.691)PK;GLYDGPVCEVS(0.002)VT(0.998)PK;GLYDGPVCEVS(0.001)VT(0.999)PK;GLYDGPVCEVS(0.225)VT(0.775)PK;GLYDGPVCEVS(0.404)VT(0.596)PK;GLYDGPVCEVS(0.028)VT(0.972)PK 190.24 6.3601e-05 1007297000.0 4891501.0 4718906.0 4468557.9 4660480.0 4443209.0 3948096.2 4617556.0 4205311.8 3218096.6 4041270.8 True False 4619650.956649958 5080830.916525687 4181055.7497119857 4025714.584223573 3885013.3626275533 4491910.614301064 4832281.503513631 4217548.561111157 3861805.841131755 3924588.8115214645 1.1771044505574675 1.2946148400591238 1.0653487411057199 1.025767227487688 0.9899160266732329 1.144555730555544 1.2312835141677625 1.0746472467968229 0.9840026628508453 1.0 21.904110076664928 -5.273093523975903 24.590308651476157 1.0718833204199942 1.2358596437374274 0.4395589296779555 0.07705838374469752 529.1258460296954 1116459.4540234988 0.02170495459466052 0.0458202968426512 5.332200558300416e-06 5.273093523975903 0.16397632331743317 GMAYGHIDSYGADDS(ph)EEEGAGPVERPPVR ddPTM_A459_Selumetinib_30min_R2 1 GMAYGHIDSYGADDSEEEGAGPVERPPVR 29 1 Q8NG27-3;Q8NG27;K7EPI8 Q8NG27-3 PJA1 E3 ubiquitin-protein ligase Praja-1 1 GMAYGHIDS(0.001)Y(0.004)GADDS(0.995)EEEGAGPVERPPVR 62.707 0.00072534 8323700.0 35002.0 27498.0 42237.0 36981.0 37031.0 32401.0 31180.0 33605.0 31320.0 39638.0 True False 33056.72896410772 29607.008179994158 39519.5174041685 31944.124004216705 32378.834718659673 36863.94364300664 32629.931781997886 33702.78498639275 37584.87515391749 38493.547948107764 0.8587602527226306 0.7691420967458407 1.0266530239676483 0.8298565787513227 0.8411496586988763 0.9576655207959018 0.8476727535218505 0.8755437412998841 0.97639415323796 1.0 15.232329029945857 -14.522878745278362 0.0950142653721794 1.397625727697868 0.7941030029446599 0.2562788496797248 0.06991081551057612 291.7221970275242 1.8991099563262945 22.81464873305554 1.378055741680044 3.000000000013646e-15 14.522878745278362 -0.6035227247532082 GMDGSTNETAS(ph)SR ddPTM_A459_Selumetinib_30min_R2 2 GMDGSTNETASSR 13 0 Q9Y3B9 Q9Y3B9 RRP15 RRP15-like protein 1 GMDGSTNETAS(0.9)S(0.1)R;GMDGSTNETAS(0.971)S(0.028)R 132.31 0.005448399999999999 7037040.0 19092.5 19339.1 19294.2 23661.1 20250.0 18028.9 16239.0 17220.0 15524.2 21549.3 True False 18031.41528333314 20822.346784992555 18052.832177936594 20438.417362325854 17706.01396270308 20512.217324940662 16994.14567696804 17270.107349075544 18629.47378238972 20927.11571719458 0.8616292625800213 0.9949936277116324 0.8626526666120379 0.9766476010610868 0.846079995063777 0.9801741244297215 0.812063444701314 0.8252502438683278 0.8902074243840002 1.0 14.353085865187905 -7.264468049460977 24.986756449333818 0.8673178031750461 0.9203138952879308 0.0538271015276901 0.06896694760828134 579.4698086456173 4780625.007869835 0.026034892759015483 0.018375631980349506 5.439161455255979e-08 7.264468049460977 0.052996092112884696 GMGELLPT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GMGELLPTK 9 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;C9JE24 Q8TB72-3 PUM2 Pumilio homolog 2 1 GMGELLPT(1)K 138.9 0.024723 29891000.0 2930.1 2961.0 2558.9 2780.7 1534.1 3609.7 2987.5 2322.9 1379.0 1517.5 True False 2998.365629017891 2614.324743468445 2211.4154350315657 2295.1029452037105 1395.3409258673532 3573.389695345365 2762.150469749951 2261.2891461574072 2340.0622818249517 1712.2859067017346 1.751089357964435 1.5268038668286708 1.2914989409048352 1.3403736702036044 0.8148994980371637 2.0869118184991398 1.6131362519186427 1.3206259172647061 1.3666305800136276 1.0 10.741707898633914 -8.750170697367745 1.5719388038523288 1.0023363443765225 1.4660034016388572 0.16969577074512077 0.31307047117688036 1.6155124465507176 7.179719298684117 0.3093223009335444 0.08918596102091654 1.7775806031673171e-09 8.750170697367745 0.4636670572623347 GMGPGT(ph)PAGYGR ddPTM_A459_Selumetinib_30min_R1 2 GMGPGTPAGYGR 12 0 P23246 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 GMGPGT(1)PAGYGR;GMGPGT(1)PAGYGR 193.62 0.00036671 253620000.0 3625.6000000000004 5015.3 4883.700000000001 5284.9 4984.1 4286.5 4721.9 4171.3 2324.5 3826.8 True False 3710.069425810472 4428.106344450285 4220.520364243878 4361.991424859599 4533.289035014325 4243.381701830599 4365.723281376501 4060.6635737080355 3944.5067252371978 4318.007056188595 0.8592087455005838 1.0254977092045032 0.9774232207877015 1.0101862660478902 1.0498567918079678 0.9827176395529409 1.0110505204292148 0.9404022552228735 0.9135016858260817 1.0 12.076149885576923 -10.511072620839176 12.706788556874942 0.9999999999244031 0.9796078456545045 0.011672772152865551 0.05420513353288555 0.0 0.0 0.05238732895893507 0.012705793573039307 3.0826724360382496e-11 10.511072620839176 -0.0203921542698986 GMGPGT(ph)PAGYGR ddPTM_A459_Selumetinib_30min_R2 3 GMGPGTPAGYGR 12 0 P23246 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 GMGPGT(1)PAGYGR;GMGPGT(1)PAGYGR;GMGPGT(1)PAGYGR 171.62 0.00060423 183531000.0 90912.0 107345.0 113106.0 117767.0 115628.0 87218.0 99662.0 107092.0 86550.0 101233.0 True False 85859.47498957088 115578.01633142322 105828.88310050168 101726.93144059357 101101.77691256451 99231.48781382528 104296.48047650655 107403.61998996507 103862.41840905363 98310.14025507815 0.8733531939512807 1.1756469478279796 1.076479830319794 1.0347552264359519 1.0283962229149821 1.009371846651389 1.0608923983415757 1.0924978818186275 1.0564771664405055 1.0 16.585052611387077 GMGS(ph)LDAMDK ddPTM_A459_Selumetinib_30min_R2 3 GMGSLDAMDK 10 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 GMGS(1)LDAMDK;GMGS(1)LDAMDK;GMGS(1)LDAMDK 122.18 0.004546 12315500.0 66861.0 57341.0 62018.0 69638.0 67055.0 57752.0 56784.0 65133.0 50502.0 60500.0 True False 63145.13328578948 61738.87031962494 58027.82940009289 60153.184267749435 58630.95142069417 65706.81377954141 59424.5685153614 65322.5262466514 60603.81114377843 58753.20780212219 1.07475209691459 1.0508170128779744 0.9876538076955331 1.02382808561436 0.9979191539321601 1.1183527885122224 1.0114267924825537 1.1118120812510246 1.031497911533426 1.0 15.842380001505814 GMKDDKEEEEDGTGS(ph)PQLNNR ddPTM_A459_Selumetinib_30min_R1 2 GMKDDKEEEEDGTGSPQLNNR 21 2 P49407-2;P49407 P49407-2 ARRB1 Beta-arrestin-1 1 GMKDDKEEEEDGT(0.051)GS(0.949)PQLNNR;GMKDDKEEEEDGT(0.057)GS(0.943)PQLNNR 136.67 3.6692e-05 18762700.0 2433.5 2918.7 2756.0 2665.9 2546.5 2433.3 2114.26 2248.21 972.1 1606.1 True False 2490.195815233282 2576.9772471331817 2381.750337624367 2200.3506101408175 2316.169524621091 2408.8232112596284 1954.779665999509 2188.5801675847183 1649.5827006251152 1812.2585797388174 1.3740841638571073 1.4219699528223921 1.3142442056848338 1.2141482649004383 1.2780568681070321 1.3291829533546962 1.0786427984693177 1.2076533625240922 0.9102358344816627 1.0 10.823573103783213 -7.501440835141515 0.5919443506164083 0.958744108558212 1.3655096729100582 0.746279524736106 0.0800742262656833 0.40406858438382015 0.2897510571064267 0.07475401808247238 0.048723325725787796 3.151803727865753e-08 7.501440835141515 0.4067655643518462 GMKDDKEEEEDGTGS(ph)PQLNNR ddPTM_A459_Selumetinib_30min_R2 2 GMKDDKEEEEDGTGSPQLNNR 21 2 P49407-2;P49407 P49407-2 ARRB1 Beta-arrestin-1 1 GMKDDKEEEEDGT(0.065)GS(0.935)PQLNNR;GMKDDKEEEEDGT(0.281)GS(0.719)PQLNNR 57.662 0.010551 38582000.0 282984.0 227490.0 219929.0 223486.0 186545.0 161324.0 209340.0 215348.0 140748.0 213733.0 True False 267256.88215470716 244937.7515043589 205779.00758058985 193046.8212651462 163109.54936654045 183544.91664653542 219074.72479934065 215974.62702721934 168901.53282770087 207561.9729449754 1.2876004133259846 1.1800704533160888 0.9914099613764117 0.9300683479064965 0.7858354160556218 0.8842897089593242 1.0554665755534 1.040530806114828 0.8137402551693638 1.0 17.663182628783233 -5.186499384685664 2.0677562022935847 0.9292622742441029 1.2896879119287359 0.6814519264613286 0.08346164582936093 0.23315046593661323 1.7533907497248749 0.02503862240711076 0.11353151872589849 6.508795330147417e-06 5.186499384685664 0.360425637684633 GMLS(ph)S(ph)S(ph)T(ph)SGAISDKGVLR ddPTM_A459_Selumetinib_30min_R2 1 GMLSSSTSGAISDKGVLR 18 1 A0A2R8Y6S3;C9J167;P54278;P54278-3 A0A2R8Y6S3 PMS2 Mismatch repair endonuclease PMS2 4 GMLS(1)S(1)S(0.999)T(0.942)S(0.054)GAIS(0.005)DKGVLR 52.72 0.044825 21225000.0 36062.0 22225.0 27599.0 25748.0 29522.0 22598.0 22669.0 23079.0 17708.0 21832.0 True False 34057.818407623934 23929.58603536149 25823.310387519174 22241.077982222538 25813.1824299714 25710.6693757805 23723.153417771326 23146.156069065873 21250.094802859858 21201.65343365177 1.6063755835932378 1.128666031177544 1.2179856853301734 1.0490256362233037 1.2175079887401659 1.2126728444193844 1.1189294029359698 1.0917146694006301 1.0022847920498126 1.0 14.371889158843274 -4.76133356709452 8.892030407469088 1.125528631247484 1.6100222040926817 0.7753543749194448 0.07911319280504031 0.03898835156832835 40.04771614131777 0.019678710570143594 0.11313460568267475 1.732472832056367e-05 4.76133356709452 0.4844935728451978 GMLTSSGGQS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 GMLTSSGGQSPSR 13 0 O43365 O43365 HOXA3 Homeobox protein Hox-A3 1 GMLT(0.002)S(0.002)S(0.002)GGQS(0.917)PS(0.077)R 96.707 0.013964 2635600.0 10646.0 8586.7 11978.0 11851.0 9313.2 7184.4 8413.8 10618.0 8962.5 8674.6 True False 10054.337939314628 9245.272279407809 11207.348520660329 10236.873355884705 8143.192554935624 8173.985886510194 8805.058371628415 10648.896622095477 10755.250433173227 8424.141758682461 1.1935148086690235 1.0974734927601424 1.330384606729738 1.2151829407825345 0.966649516141241 0.9703048833533172 1.045217260565844 1.2640927618674083 1.276717645698231 1.0 13.040313998426884 -6.142856489611767 19.57387917929839 1.0922414454043916 1.2098475321785223 0.21168731369272553 0.11505665314601259 7.4258716186596025 1199.220384674161 0.03766352783034432 0.0486236265738004 7.196867555193763e-07 6.142856489611767 0.11760608677413065 GMSNNT(ph)PQLNR ddPTM_A459_Selumetinib_30min_R1 1 GMSNNTPQLNR 11 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52;F8W145;F8VWH8 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 GMS(0.02)NNT(0.98)PQLNR 109.6 0.021757 4828400.0 1152.9 1462.5 1603.1 1333.5 1919.8 1413.9 1519.3 1168.2 762.64 1105.5 True False 1179.7603268471132 1291.2698201021965 1385.407825197976 1100.6292578951868 1746.154428968218 1399.6774497184845 1404.6979778045531 1137.2155411516142 1294.144378978231 1247.4016934818897 0.9457741904727032 1.0351676022643974 1.1106348760284812 0.8823374728817187 1.3998332999646272 1.1220743542615734 1.1260991428379419 0.9116674661369816 1.0374720394726 1.0 10.284710407307095 -7.749826012126732 24.983240051029796 0.9809273029190754 1.092915791594877 0.11834769172450954 0.1319660700896307 454.17870039734754 977056.2823228784 0.06407824997894734 0.036595064368136254 1.7789919704094003e-08 7.749826012126732 0.11198848867580169 GMSNNT(ph)PQLNR ddPTM_A459_Selumetinib_30min_R2 1 GMSNNTPQLNR 11 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52;F8W145;F8VWH8 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 GMS(0.002)NNT(0.998)PQLNR 174.46 0.00030539 7732200.0 25550.0 26689.0 29869.0 33983.0 31660.0 26131.0 31830.0 24101.0 24184.0 28888.0 True False 24130.033284753797 28735.96048133915 27947.261058908272 29354.456776055176 27682.587756008885 29730.30805639969 33310.158069948455 24171.12991986467 29021.47575741829 28053.928379962083 0.8601302804347721 1.0243114651231597 0.9961977759546147 1.0463581562795325 0.9867633288670391 1.0597556126091412 1.1873616278902568 0.861595195955845 1.0344888375115155 1.0 14.775915184517773 -4.761101958782259 24.460982031089124 1.0227665044521774 0.8601300389687132 0.2898976186122362 0.07592940532330299 8.063089078424118 583393.3353107458 0.018720499803496934 0.10619055572909132 1.7333970024952305e-05 4.761101958782259 -0.16263646548346422 GMTRWGEFDDLY(ph)RISELDRTQIPMSEK ddPTM_A459_Selumetinib_30min_R2 1 GMTRWGEFDDLYRISELDRTQIPMSEK 27 3 Q6ZTQ3-4;Q6ZTQ3-3;Q6ZTQ3-2;Q6ZTQ3 Q6ZTQ3-4 RASSF6 Ras association domain-containing protein 6 1 GMT(0.029)RWGEFDDLY(0.698)RIS(0.124)ELDRT(0.125)QIPMS(0.024)EK 40.937 0.040794 3566600.0 12418.0 15001.0 14705.0 11764.0 10225.0 9701.4 10851.0 10649.0 6018.9 10136.0 True False 11727.857273192658 16151.52846418258 13758.896309593436 10161.722905968081 8940.444087340196 11037.679789459109 11355.593000848592 10679.98682696315 7222.8481821173045 9843.347343509264 1.1914501097968515 1.6408573121046015 1.3977863250620834 1.032344237315648 0.908272742527526 1.1213339735224717 1.1536312399192648 1.0849954242451445 0.7337796716967501 1.0 13.264933288709942 -5.750030458434434 5.208920870914369 1.0138089748632813 1.438994087058103 0.6007412274113166 0.15106612979197248 0.11485343719558297 8.864629996545691 0.041773696392125755 0.0694615694670675 1.7781546980985556e-06 5.750030458434434 0.4251851121948218 GMYDGPVFDLTT(ph)TPK ddPTM_A459_Selumetinib_30min_R1 1 GMYDGPVFDLTTTPK 15 0 Q14195-2;Q14195;H0YBT4 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 GMYDGPVFDLT(0.002)T(0.588)T(0.41)PK 116.63 0.022763 7983900.0 2758.8 3173.5 3289.3 3464.7 2996.4 2687.8 2938.7 2618.1 2023.3 2721.7 True False 2823.074672309668 2801.945144679877 2842.631126831577 2859.6551854739096 2725.3761490573884 2660.763172327139 2717.0314930390564 2548.6594832126675 3433.392324014808 3071.0567066030376 0.9192518868960685 0.9123716728041695 0.9256198756342318 0.9311632635520547 0.8874392137395555 0.8663998833386136 0.8847220200125916 0.8298965882762207 1.1179840204945475 1.0 11.584519436370103 -8.262943651545358 24.999999971256283 1.0589920171176843 0.895943637419337 0.7382064918778859 0.03915057910958378 67.09204995491942 1114966.633381101 0.03174212986730635 0.009895196339571331 5.4582867619134774e-09 8.262943651545358 -0.1630483796983473 GMYDGPVFDLTT(ph)TPK ddPTM_A459_Selumetinib_30min_R2 1 GMYDGPVFDLTTTPK 15 0 Q14195-2;Q14195;H0YBT4 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 GMYDGPVFDLT(0.028)T(0.547)T(0.425)PK 111.39 0.0076393999999999984 922300.0 6600.6 8523.8 6628.8 7242.1 6901.3 7100.6 6657.8 6876.7 5080.6 7962.8 True False 6233.765076295334 9177.548051663187 6202.310224891734 6255.71348668067 6034.296995595202 8078.643197170856 6967.400892180423 6896.710058501033 6096.861963824819 7732.893274160973 0.8061361841272411 1.1868194382469297 0.8020685149782687 0.8089745021548124 0.7803414299998767 1.0447115860457026 0.9010082830784178 0.8918667068050713 0.7884321880139145 1.0 12.916792586433326 -5.33152527298083 24.999998996023184 0.8742540325130095 0.996500139551687 0.1361861594118764 0.1200046314043102 263.2019543796159 93884.57079093925 0.030374398934368576 0.06322936993462099 4.660953036406113e-06 5.33152527298083 0.12224610703867755 GMYDGPVFDLTTT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 GMYDGPVFDLTTTPK 15 0 Q14195-2;Q14195;H0YBT4 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 GMYDGPVFDLT(0.001)T(0.085)T(0.914)PK;GMYDGPVFDLT(0.001)T(0.036)T(0.964)PK 130.19 0.0019149 155395600.0 14794.6 16614.2 18677.5 18160.9 14794.8 15276.4 15176.5 15438.5 11113.900000000001 15103.0 True False 15139.28539471967 14669.001740267964 16141.198088163688 14989.439737314367 13456.612952234085 15122.733285861415 14031.724386329757 15029.020828684459 18859.476572860265 17041.61716567795 0.8883714055735507 0.860775218552118 0.9471635192387892 0.8795784808206643 0.7896323935345694 0.8874001298608447 0.8233798617768413 0.881901094395731 1.1066717665060277 1.0 14.056774626275267 -8.224320596251147 9.140423938965997 1.0531872286733195 0.8686221482594626 0.7173305410170747 0.046088350984328307 0.19219187741244625 46.32997140331285 0.03161528753518759 0.01174374558617133 5.9659471768048746e-09 8.224320596251147 -0.18456508041385689 GMYDGPVFDLTTT(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 GMYDGPVFDLTTTPK 15 0 Q14195-2;Q14195;H0YBT4 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 GMYDGPVFDLTT(0.166)T(0.833)PK;GMYDGPVFDLT(0.001)T(0.033)T(0.966)PK;GMYDGPVFDLT(0.002)T(0.119)T(0.879)PK 158.31 0.00034446 60270000.0 163318.0 132359.0 131377.0 120987.0 117007.0 88824.0 117480.0 109169.0 80749.0 103718.0 True False 154241.43937375429 142510.5096987364 122924.34685246229 104508.36188578379 102307.53460414805 101058.69973600886 122943.05278220365 109486.66371609917 96901.05631557087 100723.39184827266 1.5313368279545228 1.4148700424367249 1.2204150852825988 1.0375778651617762 1.0157276549846703 1.00332899718311 1.2206008011267349 1.0870033435830606 0.962051163463005 1.0 16.620039246008773 -5.321639559641479 1.827405614879813 1.053276697263386 1.5271259737798093 0.8602821783652905 0.06887098736933864 0.14763879693928272 0.885365536788793 0.021138797089038028 0.08141822227075053 4.768265622586418e-06 5.321639559641479 0.4738492765164233 GNAEGS(ph)S(ph)DEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R1 1 GNAEGSSDEEGKLVIDEPAK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 2 GNAEGS(1)S(1)DEEGKLVIDEPAK 66.12 0.031674 11622000.0 4135.9 6034.6 2970.0 3267.0 2949.5 4083.0 4465.4 4604.0 2819.3 5646.3 True False 4232.2584229395225 5328.066226590574 2566.6903130422243 2696.4797791852848 2682.7182457765184 4041.9287270673817 4128.571282885836 4481.886964100349 4784.146186475043 6371.057604619438 0.664294483834341 0.8362922700192467 0.40286722744135983 0.4232389575680745 0.42107894987974526 0.6344203706676135 0.6480197698875535 0.7034761325734498 0.7509186831094135 1.0 12.637317166451373 -8.469888744392305 0.8439809363601776 0.9939461176687108 0.5583409571406204 0.5260998656789668 0.12610697795006645 0.5600513570236709 0.8929689076150574 0.13473689954344115 0.04874750611365124 3.3893097083103172e-09 8.469888744392305 -0.4356051605280904 GNAEGS(ph)S(ph)DEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R2 1 GNAEGSSDEEGKLVIDEPAK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 2 GNAEGS(1)S(1)DEEGKLVIDEPAK 69.986 0.022661 2742700.0 36397.0 26761.0 25903.0 31676.0 31926.0 27955.0 36599.0 34277.0 22366.0 26534.0 True False 34374.200448735166 28813.48264982268 24236.429181053994 27361.674155852168 27915.170457938693 31805.54749977625 38300.92601954267 34376.74039513719 26839.82495825411 25767.89447638861 1.3339933722653436 1.1181931327848604 0.9405669214945788 1.0618513740392703 1.083331448889534 1.234309133364389 1.4863816698193253 1.3340919424610713 1.0415994594687479 1.0 14.653287037330092 -6.803591722182251 5.928386511475146 1.2584186767304455 1.096228005374662 0.08347965017682468 0.15948995982429837 0.3378285546317105 29.116080120590475 0.05771114101809374 0.051714476658923134 1.571839787781661e-07 6.803591722182251 -0.16219067135578347 GNAEGS(ph)SDEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R1 2 GNAEGSSDEEGKLVIDEPAK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 GNAEGS(0.574)S(0.426)DEEGKLVIDEPAK;GNAEGS(0.783)S(0.217)DEEGKLVIDEPAK 92.565 0.00075951 139853000.0 8617.8 11560.9 6367.700000000001 5940.200000000001 6112.2 8274.7 8711.8 8478.8 5724.4 10855.8 True False 8818.577972680238 10207.344453483398 5503.001315272384 4902.855581364073 5559.352589196558 8191.46403082647 8054.66191208958 8253.914680976119 9713.888706366026 12249.247674446573 0.7199281300415591 0.8333037852420248 0.44925218768760117 0.40025769024101204 0.4538525742110715 0.6687320110209596 0.6575638052361852 0.6738303363883149 0.7930192093862535 1.0 13.580405523905846 -8.48420974793878 0.9391693961008322 0.9981814907645895 0.5808186460494281 0.5090508388863556 0.1255999063637308 0.5461071013821811 1.0669021891151305 0.1354923031781154 0.046550956890815516 3.2793687365603193e-09 8.48420974793878 -0.4173628447151614 GNAEGS(ph)SDEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R2 2 GNAEGSSDEEGKLVIDEPAK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 GNAEGS(0.5)S(0.5)DEEGKLVIDEPAK;GNAEGS(0.777)S(0.223)DEEGKLVIDEPAK 67.153 0.0081572 45938000.0 83229.0 66468.0 77610.0 83610.0 69584.0 61130.0 95384.0 85625.0 58996.0 64643.0 True False 78603.46537208496 71565.88187169429 72616.65709537883 72222.17376470518 60842.23583114728 69550.1026171103 99819.54499981043 85874.15457401816 70796.84848596799 62776.58862731544 1.2521143166719146 1.140009093143912 1.1567474226177012 1.1504634983188584 0.9691867169200321 1.1078987268646765 1.5900759691229351 1.3679327987034402 1.127758771765479 1.0 15.937939012416994 GNAEGSS(ph)DEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R1 2 GNAEGSSDEEGKLVIDEPAK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 GNAEGS(0.411)S(0.589)DEEGKLVIDEPAK;GNAEGS(0.107)S(0.893)DEEGKLVIDEPAK 83.229 0.001646 146021000.0 5657.7 7516.2 3251.0 3828.0 3881.3 4584.700000000001 5316.299999999999 6114.200000000001 2987.5 6220.1 True False 5789.513402032188 6636.199809813416 2809.532056464736 3159.5116604595255 3530.237100299172 4538.582080574536 4915.287210822313 5952.031554279401 5069.569301633095 7018.510423904751 0.8248920429487928 0.9455282401819621 0.40030318212474086 0.45016840748691656 0.5029895073284116 0.6466588786583997 0.7003319670340663 0.8480476902915227 0.7223141372514537 1.0 12.77694915677642 -8.336233765268142 0.8482066770621688 0.9781534148414568 0.6225486878220908 0.3025934537853564 0.1632249133669198 0.8000251576208066 1.2625065314888748 0.1727773811602569 0.06379651425481858 4.6106933053935184e-09 8.336233765268142 -0.35560472701936596 GNAEGSS(ph)DEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R2 3 GNAEGSSDEEGKLVIDEPAK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 GNAEGS(0.066)S(0.934)DEEGKLVIDEPAK;GNAEGS(0.255)S(0.745)DEEGKLVIDEPAK;GNAEGS(0.068)S(0.932)DEEGKLVIDEPAK 75.743 0.0032761 422712000.0 212633.0 180909.0 206825.0 199254.0 180089.0 189260.0 262016.0 228330.0 155095.0 154095.0 True False 200815.70909734056 194784.13858588133 193518.1046740336 172115.26146767786 157464.60980391284 215328.8470687769 274200.26317485404 228994.40249793342 186118.3337163741 149645.87696310758 1.3419394718562674 1.3016338474457385 1.2931736483574612 1.1501503747417625 1.0522482342947064 1.438922684932123 1.832327550477405 1.5302419762248962 1.2437251028456877 1.0 17.19119300474746 -6.912808412036773 9.38732223229587 1.4726651643880333 1.2317607948038896 0.11842714924844988 0.21637913827579602 0.48494574513060135 47.665583083512225 0.07670950514603202 0.06765765406970654 1.2223387730435544e-07 6.912808412036773 -0.24090436958414374 GNAEGSS(ph)DEEGKLVIDEPAKEK ddPTM_A459_Selumetinib_30min_R1 3 GNAEGSSDEEGKLVIDEPAKEK 22 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 GNAEGS(0.107)S(0.893)DEEGKLVIDEPAKEK;GNAEGS(0.216)S(0.784)DEEGKLVIDEPAKEK;GNAEGS(0.328)S(0.672)DEEGKLVIDEPAKEK 119.2 3.7298e-05 67460000.0 9387.0 9570.1 11249.8 11460.400000000001 9561.4 9846.3 9496.8 10274.8 6661.3 9981.7 True False 9605.698836077587 8449.628242981218 9722.138950728082 9459.056278351718 8696.573058202272 9747.255161725094 8780.448730082453 10002.27892674593 11303.739577897422 11262.94842499156 0.8528582812972247 0.7502145907222824 0.8631966145876555 0.8398383728156693 0.772140005445225 0.8654266000274611 0.7795870493910241 0.8880693180261477 1.0036217117726784 1.0 13.45929692644355 -8.105607485936444 3.0273186571393307 1.0036078587890809 0.8178627510918862 0.7843371026929529 0.03821843900059332 0.1115412002443812 1.845517557119294 0.0292510552946144 0.009602681136033138 7.841380242200676e-09 8.105607485936444 -0.18574510769719466 GNAEGSS(ph)DEEGKLVIDEPAKEK ddPTM_A459_Selumetinib_30min_R2 1 GNAEGSSDEEGKLVIDEPAKEK 22 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 GNAEGS(0.042)S(0.958)DEEGKLVIDEPAKEK 63.706 0.0094303 25766000.0 58830.0 58745.0 60579.0 57456.0 47398.0 30685.0 40890.0 38179.0 25122.0 48063.0 True False 55560.464115149334 63250.55260505336 56681.41309342817 49630.39368287166 41443.43949650376 34911.58021930367 42791.466021997876 38290.09456912628 30147.101967328086 46675.29630732893 1.1903612512562725 1.355118394719688 1.2143771454650216 1.0633118075155898 0.8879095104961622 0.7479669757087729 0.9167904524963623 0.8203503265840862 0.6458898893501915 1.0 15.510371560645964 -6.0375005493331795 1.7599757486241874 0.8190301932495272 1.2765269738440943 0.7928192571530525 0.09660948143478804 0.14642339337700808 0.9089932203968862 0.03146560650979793 0.050197360685704434 9.172747751406667e-07 6.0375005493331795 0.4574967805945671 GNASESEEDRS(ph)AGSVESPSVSSTHR ddPTM_A459_Selumetinib_30min_R2 1 GNASESEEDRSAGSVESPSVSSTHR 25 1 C9JMX4 C9JMX4 IGFBP3 1 GNAS(0.001)ES(0.004)EEDRS(0.226)AGS(0.226)VES(0.226)PS(0.226)VS(0.031)S(0.031)T(0.031)HR 44.105 0.031331 15857000.0 0.0 590.34 564.43 1044.6 0.0 838.15 0.0 772.47 871.8 873.08 True False 0.0 635.6171797577193 528.1151883049184 902.3236779644895 0.0 953.5975545318353 0.0 774.7177598107073 1046.1843601272442 847.8719118657326 0.0 0.7496617954462613 0.6228714277641382 1.0642216888385139 0.0 1.1246953003000826 0.0 0.9137202789345263 1.2338943482926887 1.0 9.72770252287253 -7.988179557483014 24.938358115819266 1.1025673872389936 0.5414114164065071 0.2872419974568836 0.3963206314428264 251.8629454257327 531371.5177849437 0.20255665649300456 0.09718985388239954 1.0275913563569761e-08 7.988179557483014 -0.5611559708324865 GNDPLTS(ph)SPGR ddPTM_A459_Selumetinib_30min_R2 2 GNDPLTSSPGR 11 0 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 GNDPLT(0.071)S(0.464)S(0.464)PGR;GNDPLT(0.07)S(0.465)S(0.465)PGR 85.973 0.034119 31412000.0 132874.0 107514.0 122302.0 136619.0 146864.0 83193.0 101085.0 104422.0 112981.0 115065.0 True False 125489.39501676621 115759.9780880026 114433.22247234934 118011.25651907948 128413.63133918156 94652.08059913729 105785.6527961276 104725.85073200718 135580.35695289753 111742.77447522625 1.123020218587714 1.0359504552454706 1.0240771540688707 1.0560974261941471 1.1491895734846935 0.8470532528268481 0.9466889764723054 0.9372046758622881 1.213325493210804 1.0 16.769822021140456 -6.734873148836839 24.99971877899152 0.9822942246948031 1.071173815424921 0.18025254233863164 0.09366991216332803 405.8407793551463 381908.92616434296 0.031205411067036174 0.031196762193804267 1.8413097429879938e-07 6.734873148836839 0.08887959073011797 GNDPLTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 4 GNDPLTSSPGR 11 0 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 GNDPLTS(0.006)S(0.994)PGR;GNDPLTS(0.005)S(0.995)PGR;GNDPLTS(0.004)S(0.996)PGR;GNDPLTS(0.003)S(0.997)PGR 169.09 0.00044143 2150770000.0 39002.4 46621.6 45112.7 46559.9 44237.0 37499.2 43802.9 39885.6 21860.4 35370.600000000006 True False 39911.08003454057 41163.12139820615 38986.643126323186 38429.08750256778 40235.77116067667 37121.99209454941 40498.81198708291 38827.704321312085 37095.502179554875 39910.761048820015 1.000007992474014 1.0313790144932142 0.9768453946201021 0.9628753371944021 1.008143420554148 0.930124886597394 1.014734144947614 0.9728630399660105 0.929461157961347 1.0 15.284490169069896 -5.310313445145964 8.837188083230766 0.9740223736741621 1.015647151238525 0.2536215190624498 0.028345135124192893 0.46921489330158495 81.69656362366499 0.007085350721935124 0.01485778014100655 4.894254568152207e-06 5.310313445145964 0.04162477756436289 GNDPLTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 4 GNDPLTSSPGR 11 0 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 GNDPLTS(0.003)S(0.997)PGR;GNDPLTS(0.002)S(0.998)PGR;GNDPLT(0.001)S(0.006)S(0.993)PGR;GNDPLTS(0.004)S(0.996)PGR 143.55 0.00083027 2263150000.0 609975.0 563308.0 648380.0 662430.0 752400.0 527776.0 519978.0 566544.0 528713.0 601670.0 True False 576075.0314233932 606511.9122792985 606663.9367027665 572205.8912445119 657876.7854586574 600472.3533264863 544158.0073168606 568192.5492435922 634470.3734755153 584298.2237736016 0.9859263779768144 1.0380177238298505 1.0382779067591876 0.979304519443867 1.1259263826096542 1.0276812916671672 0.9313018338520671 0.9724358660103511 1.0858673664586629 1.0 19.156345378032768 -7.025889284386823 24.882137467122707 0.992873868397172 1.0355783302502375 0.09745615606986502 0.051687006955153894 1516.9165829565716 1457900.6651103268 0.01982939838967101 0.015415095107800163 9.421297450444107e-08 7.025889284386823 0.042704461853065534 GNDSDGEGES(ph)DDPEK ddPTM_A459_Selumetinib_30min_R2 1 GNDSDGEGESDDPEK 15 0 K7EKZ3;O75351 K7EKZ3 VPS4B Vacuolar protein sorting-associated protein 4B 1 GNDS(0.008)DGEGES(0.992)DDPEK 118.21 0.0020510000000000003 15180000.0 43063.0 28564.0 35586.0 37107.0 33027.0 39670.0 51543.0 50583.0 41572.0 30890.0 True False 40669.730854847476 30754.766952263937 33296.43550310723 32052.96258685461 28877.85299487381 45134.18241159447 53939.851630516896 50730.18815553357 49887.561618731124 29998.125438141404 1.355742409261932 1.0252229598707023 1.109950539135094 1.068498851801605 0.9626552517230555 1.504566760501914 1.7981074098028325 1.6911119416492668 1.663022635251105 1.0 14.872584730084133 -6.863205802971713 5.506759810389945 1.6018715367779301 1.0996816647829082 0.4639726936199374 0.2249031746648242 0.15874461847872934 7.242359270543171 0.0760214497430591 0.06717379675306172 1.3702322881825874e-07 6.863205802971713 -0.502189871995022 GNDT(ph)PLALESTNTEK ddPTM_A459_Selumetinib_30min_R1 4 GNDTPLALESTNTEK 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GNDT(0.999)PLALES(0.001)TNTEK;GNDT(1)PLALESTNTEK;GNDT(0.986)PLALES(0.012)T(0.002)NTEK;GNDT(0.998)PLALES(0.002)TNTEK 235.02 3.2107e-14 24447100.0 5831.33 8239.5 4961.73 4988.33 5556.3 5569.22 6214.450000000001 6208.59 3150.0200000000004 5385.36 True False 5967.18864320702 7274.815509560369 4287.954318831986 4117.21180805122 5053.73364604444 5513.198703247177 5745.689033217603 6043.918024857467 5345.353871641936 6076.6234138486025 0.9819908585428906 1.1971805744915986 0.7056475326510696 0.6775492782172595 0.8316680665987957 0.9072799691161735 0.9455397581695121 0.9946178351423588 0.879658571479005 1.0 12.569054171278044 -10.458030969453699 12.807822395705973 0.999988700198078 0.9006729514024046 0.04134022423858896 0.14086662581958426 0.0 0.0 0.148691036908915 0.036062873574004166 3.4831247605654135e-11 10.458030969453699 -0.0993157487956734 GNDT(ph)PLALESTNTEK ddPTM_A459_Selumetinib_30min_R2 2 GNDTPLALESTNTEK 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GNDT(0.616)PLALES(0.289)T(0.086)NT(0.008)EK;GNDT(0.999)PLALES(0.001)T(0.001)NTEK 197.94 6.2545e-05 24127000.0 83552.0 64652.0 85539.0 91167.0 99857.0 84576.0 97565.0 92916.0 82468.0 84163.0 True False 78908.51432515653 69610.60051105474 80035.51386782143 78749.89732815283 87312.07092709353 96225.57629551327 102101.96582137978 93186.3701769281 98963.90434844384 81732.99550826462 0.9654425833099133 0.8516829718300966 0.9792313785896719 0.9635019105618104 1.0682597693151326 1.1773161585125458 1.2492135542867202 1.1401315906438954 1.2108194950280133 1.0 16.31863098969918 -6.3812772437220895 1.8733935657659113 1.1707350579105782 0.9262470751648947 0.6792029761667089 0.06949995012449657 0.1806573647286088 1.2544748675287598 0.023970119974552236 0.028840572797166102 4.1564518734648555e-07 6.3812772437220895 -0.2444879827456835 GNDT(ph)PLALESTNTEKETSLEETK ddPTM_A459_Selumetinib_30min_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GNDT(0.998)PLALES(0.001)T(0.001)NTEKETSLEETK 92.551 0.00017098 6621900.0 690.27 1345.5 1297.7 1424.2 1245.5 1003.9 1376.1 1025.5 587.95 1125.8 True False 706.3519479683897 1187.9682344940197 1121.4794677558566 1175.4902055450516 1132.8447449108849 993.8016774682699 1272.2996690955345 998.3004087065399 997.7082078310226 1270.3073962206345 0.5560480479527228 0.9351817032856875 0.8828410124135587 0.9253588612034543 0.8917878840045151 0.7823316469895296 1.001568339191622 0.7858730978632743 0.785406910799199 1.0 10.310961935471324 -4.755785486011834 24.99659563588078 0.8825252949679353 0.5560475255953014 0.6164588296047929 0.07840744960670101 121.3353429776679 536383.9053131029 0.01889706414984074 0.16250158820169003 1.754747021794403e-05 4.755785486011834 -0.32647776937263395 GNDTPLALES(ph)TNTEKETSLEETK ddPTM_A459_Selumetinib_30min_R2 2 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GNDT(0.012)PLALES(0.312)T(0.312)NT(0.312)EKET(0.025)S(0.025)LEETK;GNDTPLALES(0.439)T(0.439)NT(0.094)EKET(0.022)S(0.005)LEETK 68.291 0.0017905000000000004 11621800.0 30547.0 32434.0 35349.0 34574.0 29957.0 22069.6 23230.0 21392.7 18228.7 31663.0 True False 28849.320029329694 34921.58350825262 33074.68382508114 29864.961556523318 26193.533841022032 25109.48707211811 24310.241029371733 21454.949215247867 21874.949352433458 30748.806919646206 0.9382256718031268 1.1357053169415923 1.0756412081780276 0.971255946110931 0.8518552901734313 0.8166003688447181 0.7906076191151109 0.6977489979144442 0.7114080689243585 1.0 14.908242813269542 -6.261471557635832 1.7084490751893506 0.7816158046199712 1.0594845565362603 0.590862673461771 0.09060449350239588 0.2287469509883279 1.3200703683857653 0.031642514623397434 0.042270732809733244 5.476819680073069e-07 6.261471557635832 0.2778687519162891 GNDVAFHFNPR ddPTM_A459_Selumetinib_30min_R2 1 GNDVAFHFNPR 11 0 P17931;G3V3R6 P17931 LGALS3 Galectin-3;Galectin 0 116.74 0.0081513 2814700.0 26578.0 19867.0 26622.0 26445.0 27443.0 22082.0 22210.0 21410.0 19032.0 22942.0 False True 25100.901160163838 21390.735017526527 24909.16950384199 22843.145379830476 23995.364996467215 25123.59505956213 23242.809008280085 21472.29955538369 22838.9317985108 22279.6048495254 1.1266313442133844 0.9601038780533935 1.118025641481366 1.0252940092120655 1.0770103490851797 1.127649939451117 1.0432325512620213 0.9637648288829994 1.0251048864090295 1.0 14.443436024853716 -7.5583849346309 7.804882909648041 0.9969277705558242 1.0689634520045206 0.316598827050118 0.04990481337453366 0.273244142702347 50.0362518921759 0.02250101455223994 0.01301627590670705 2.7644902677735508e-08 7.5583849346309 0.07203568144869643 GNFNS(ph)TVNNTVTVR ddPTM_A459_Selumetinib_30min_R1 1 GNFNSTVNNTVTVR 14 0 Q96BY6;A0A2R8YD85;Q96BY6-3;Q96BY6-2 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 GNFNS(0.668)T(0.318)VNNT(0.013)VT(0.001)VR 128.82 0.0011033 6870600.0 1471.6 2141.3 1869.6 2281.2 2007.5 1703.1 1952.8 1333.4 901.91 1024.7 True False 1505.885416764863 1890.5956005366381 1615.7185889776913 1882.8312434274487 1825.9219794529126 1685.9683602910757 1805.4987237917003 1298.0339005063875 1530.475397099885 1156.2302264232405 1.3024096605943862 1.6351376718329984 1.3974021367490648 1.6284224373306033 1.579202772705001 1.4581597347671513 1.5615391143829116 1.1226431128009962 1.3236770343172564 1.0 10.175212977871523 -8.092562785567612 1.0640457841335875 1.0460528170641297 1.5220011968543907 0.5886016366622571 0.13165700099217803 0.3153903561432952 0.6770586956801049 0.1140345668641376 0.04004751559122804 8.080481018713638e-09 8.092562785567612 0.47594837979026106 GNGSGGS(ph)RENSTVDFSK ddPTM_A459_Selumetinib_30min_R1 2 GNGSGGSRENSTVDFSK 17 1 Q9Y6M7-6;Q9Y6M7-13;Q9Y6M7-11;C9JRP1;Q9Y6M7-2;Q9Y6M7-9;Q9Y6M7-7;Q9Y6M7-14;Q9Y6M7-3;Q9Y6M7;Q9Y6M7-4;Q9Y6M7-8;E9PFN4;A0A0A0MST8;Q9Y6M7-10;Q9Y6M7-12 Q9Y6M7-6 SLC4A7 Sodium bicarbonate cotransporter 3;Anion exchange protein 1 GNGS(0.009)GGS(0.991)RENSTVDFSK;GNGS(0.199)GGS(0.795)RENS(0.005)T(0.001)VDFSK 142.35 0.0023691 23292000.0 5451.5 3503.7 6655.6 3852.2 6617.0 5162.1 4903.299999999999 7096.0 2377.7200000000003 4603.3 True False 5578.509343227547 3093.4851751740603 5751.8060765938835 3179.4855847497865 6018.493518326237 5110.173960811794 4533.440133330521 6907.791028943545 4034.817178202191 5194.178394939103 1.0739926354210154 0.5955677568156241 1.107356282217434 0.6121248334188305 1.1586998098082841 0.9838271950364359 0.8727925359182185 1.3299102386768393 0.7767960342165906 1.0 12.342679849135514 -6.284578795351975 24.992533775485757 1.0276303577628874 0.8478605456669721 0.14105948607128804 0.20876395419442734 1464.5282727819888 1581810.2562461086 0.06001302313336422 0.06809175576147056 5.193034461756594e-07 6.284578795351975 -0.17976981209591525 GNGSGGS(ph)RENSTVDFSK ddPTM_A459_Selumetinib_30min_R2 2 GNGSGGSRENSTVDFSK 17 1 Q9Y6M7-6;Q9Y6M7-13;Q9Y6M7-11;C9JRP1;Q9Y6M7-2;Q9Y6M7-9;Q9Y6M7-7;Q9Y6M7-14;Q9Y6M7-3;Q9Y6M7;Q9Y6M7-4;Q9Y6M7-8;E9PFN4;A0A0A0MST8;Q9Y6M7-10;Q9Y6M7-12 Q9Y6M7-6 SLC4A7 Sodium bicarbonate cotransporter 3;Anion exchange protein 1 GNGS(0.014)GGS(0.777)RENS(0.158)T(0.051)VDFSK;GNGS(0.009)GGS(0.985)RENS(0.006)T(0.001)VDFSK 124.98 0.0060851 14724900.0 87519.0 34465.0 68472.0 76578.0 43350.0 36884.0 92146.0 55459.0 42656.0 44402.0 True False 82655.0443463158 37108.35467755833 64066.586066676835 66147.94429558188 37903.9854460829 41964.43620038443 96430.9715838351 55620.37650826829 51188.391908221725 43119.99888974922 1.9168610035833076 0.860583386665624 1.4857742976868948 1.5340432745536785 0.8790349355758841 0.9732012356419726 2.2363398438481714 1.2898974475968907 1.1871148707378696 1.0 15.396069520493455 GNHECASINR ddPTM_A459_Selumetinib_30min_R1 1 GNHECASINR 10 0 P62136-3;P62136;P62136-2;E9PMD7;F8VYE8;F8W0W8;P36873;P36873-2;F8VR82;E7ETD8;C9JP48;A0A087WYY5;P62140 P62136-3;P62140 PPP1CA;PPP1CC;PPP1CB Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0 96.756 0.034584 0.0 441.47 554.42 522.28 397.6 336.54 356.59 371.0 384.69 191.23 322.42 False True 451.7553920489156 489.50824865713446 451.35724467868437 328.1666238763603 306.1000164209628 353.0030283578147 343.01517130618623 374.4867715507743 324.50334311340464 363.8057476367533 1.2417489140385345 1.3455209320823882 1.2406545185463864 0.902038040927332 0.8413831238493582 0.97030635346167 0.9428525347232125 1.0293591400999127 0.8919687091843566 1.0 8.507024525566594 -5.708699488178379 5.323525528573361 0.9380352949931006 1.2906717689367344 0.8799439916487999 0.05700887699479867 0.06006861923218688 3.603195485503431 0.01597241484569033 0.02763829075481935 1.9556922368359677e-06 5.708699488178379 0.35263647394363384 GNHECASINR ddPTM_A459_Selumetinib_30min_R2 4 GNHECASINR 10 0 P62136-3;P62136;P62136-2;E9PMD7;F8VYE8;F8W0W8;P36873;P36873-2;F8VR82;E7ETD8;C9JP48;A0A087WYY5;P62140 P62136-3;P62140 PPP1CA;PPP1CC;PPP1CB Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0 ;;; 160.91 0.00061004 22817500.0 33804.74 35730.1 36775.07 37891.73 43498.89 30889.300000000003 29052.7 33516.090000000004 27964.3 40336.63 False True 31926.00788189619 38470.48377962066 34409.00203386879 32730.811007119828 38034.1705531894 35144.02068985294 30403.70811683289 33613.6162730126 33557.94138782552 39172.006684749 0.8150209954479067 0.9820912185894867 0.878407948583992 0.8355663591741153 0.9709528250437421 0.8971718240703689 0.7761590658736942 0.8581029954255452 0.8566817027755378 1.0 15.257535415419984 -7.04299654208123 24.994539218355825 0.857447513882075 0.9005154966287147 0.006690171398435085 0.07110731236545793 1312.875894918528 763190.5124631752 0.025941763420084907 0.020096147670794467 9.05739812507742e-08 7.04299654208123 0.0430679827466397 GNIETT(ph)SEDGQVFSPK ddPTM_A459_Selumetinib_30min_R1 1 GNIETTSEDGQVFSPK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 GNIET(0.001)T(0.702)S(0.297)EDGQVFSPK 189.45 2.2504e-06 11305000.0 1801.4 2390.3 2259.5 2363.6 1620.8 2119.5 1913.0 2026.5 905.57 1792.7 True False 1843.3691150857749 2110.442564779677 1952.6723105450867 1950.8416302670146 1474.1989261754813 2098.179754352026 1768.7008698348634 1972.7506370002961 1536.686149784062 2022.810507376737 0.9112910519118922 1.043321931087151 0.965326363208085 0.9644213450309518 0.7287874572528706 1.037259667527153 0.8743779327746259 0.975252318398642 0.7596787460714248 1.0 10.982145462258579 -6.028551492142574 24.949502172169215 0.8957348724931982 0.9777407167367534 0.12742686388135427 0.09640171487008019 1327.9024805212866 1160375.3771847028 0.026925318785909796 0.034836769831289006 9.363721923061162e-07 6.028551492142574 0.08200584424355528 GNIETTS(ph)EDGQVFSPK ddPTM_A459_Selumetinib_30min_R2 1 GNIETTSEDGQVFSPK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 GNIET(0.002)T(0.064)S(0.935)EDGQVFSPK 240.66 1.7262e-21 11419000.0 23585.0 27543.0 27363.0 29806.0 29872.0 19166.0 23062.0 26381.0 18215.0 26273.0 True False 22274.24011823554 29655.459535296366 25602.49437058178 25746.3713817821 26119.21230093169 21805.942528374588 24134.428696486062 26457.76434239035 21858.508969623468 25514.43022454805 0.8730055863369801 1.1623014613418305 1.003451542725379 1.009090587373215 1.023703530553536 0.8546513614634657 0.9459129004286266 1.0369725723655272 0.8567116246473288 1.0 14.639025804089961 -6.641663533232 22.453817798762177 0.9413153848492835 1.0216570967596408 0.1667027958746916 0.08346026598803485 6.451774622627194 1214.1870297733628 0.02637587347298555 0.02637584407448025 2.282109436427528e-07 6.641663533232 0.08034171191035733 GNIETTSEDGQVFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 5 GNIETTSEDGQVFSPK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 GNIETTSEDGQVFS(1)PK;GNIETTSEDGQVFS(1)PK;GNIETTSEDGQVFS(1)PK;GNIETTSEDGQVFS(1)PK;GNIETTSEDGQVFS(1)PK 235.45 3.4930000000000003e-16 30887600.0 5514.9800000000005 6478.15 6811.23 7417.14 5040.710000000001 5595.09 5739.619999999999 5602.91 3877.33 5280.890000000001 True False 5643.468303716965 5719.685186389767 5886.302377408278 6121.875735961543 4584.778670509631 5538.808474535255 5306.675842405426 5454.302625983385 6579.545821021275 5958.743671724626 0.9470902953077671 0.9598810590780675 0.9878428577721682 1.0273769225904126 0.7694203548753539 0.9295262188937504 0.8905695788839875 0.9153443958103266 1.1041833956111373 1.0 12.540792472794026 -8.24990406645668 24.697952604359333 1.0520916976644152 0.9281923970863328 0.3426525716398865 0.06853833373474064 639.8043514257954 1369876.513021703 0.048688091263703076 0.018056543288931977 5.624655573805499e-09 8.24990406645668 -0.1238993005780824 GNIETTSEDGQVFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 GNIETTSEDGQVFSPK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 GNIETTSEDGQVFS(1)PK;GNIETTS(0.001)EDGQVFS(0.999)PK;GNIETTS(0.001)EDGQVFS(0.999)PK;GNIETTSEDGQVFS(1)PK;GNIETTSEDGQVFS(1)PK;GNIETTS(0.001)EDGQVFS(0.998)PK 204.78 2.0315e-07 293227800.0 452979.0 406752.0 408093.0 399852.0 380527.7 282028.8 377941.3 370478.2 258649.80000000002 346995.0 True False 427804.24059861025 437948.5704861797 381836.74067806354 345391.4678168271 332722.40836519934 320875.7071974567 395516.3193264782 371556.23022603255 310386.9872792378 336976.35274871683 1.2695378684854595 1.2996418499809625 1.1331262195801588 1.0249724201697483 0.9873761338182396 0.9522202510059619 1.1737212896402098 1.1026181130968022 0.9210942689224643 1.0 18.362287828546727 -5.461425822318798 2.73009584532683 1.029406395130285 1.2868210127063437 0.693381877968593 0.06904055364323138 0.16277278299144265 2.3619512859349623 0.02037744049083904 0.04852331465860285 3.4560035322358175e-06 5.461425822318798 0.25741461757605877 GNIETTSEDGQVFS(ph)PKK ddPTM_A459_Selumetinib_30min_R1 2 GNIETTSEDGQVFSPKK 17 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 GNIETT(0.004)S(0.003)EDGQVFS(0.993)PKK;GNIETTSEDGQVFS(1)PKK 73.831 0.012432 19517000.0 6446.4 5631.0 7709.4 7950.4 5222.7 6425.8 5147.6 5073.9 3809.7 4748.0 True False 6596.588577489138 4971.71990221912 6662.505824702938 6562.0118874914915 4750.307707142576 6361.162286159591 4759.312387643462 4939.323689650036 6464.782650521042 5357.452049436461 1.2312921360039086 0.9280008213497841 1.2435959786898614 1.224838193032775 0.8866729302117135 1.1873484312059701 0.8883537068976818 0.9219538773416727 1.206689782916687 1.0 12.387331317132775 -6.248066583235913 24.94436754612899 1.0135356043336872 1.1467698644363464 0.21139274389289453 0.13353965458883515 1338.4222101112694 2496568.6083650202 0.03880313863684997 0.049787056369319176 5.64850368948968e-07 6.248066583235913 0.13323426010265926 GNIETTSEDGQVFS(ph)PKK ddPTM_A459_Selumetinib_30min_R2 2 GNIETTSEDGQVFSPKK 17 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 GNIETTSEDGQVFS(1)PKK;GNIETTSEDGQVFS(1)PKK 96.579 0.0030476 21388900.0 74039.0 69550.0 70004.0 72835.0 58175.0 55038.0 56561.0 50674.0 38557.0 65100.0 True False 69924.20878160014 74884.26136150258 65500.01885459226 62914.74735261692 50866.53640890131 62618.98491478039 59191.19857349524 50821.45295046768 46269.477372592504 63220.393849886845 1.1060388036751418 1.1844953313532167 1.0360583803087062 0.9951653813167367 0.8045906282975862 0.9904871055290407 0.9362674758724424 0.8038775125498312 0.731875816567304 1.0 15.948102402509493 -5.770357860799185 1.6233861347920715 0.8753269272530894 1.1465262591377048 0.6063606769733122 0.08473342105732021 0.2604361294774552 1.393398802066737 0.028015587008218493 0.0605595536304247 1.6968448676820585e-06 5.770357860799185 0.2711993318846154 GNIWS(ph)AEK ddPTM_A459_Selumetinib_30min_R1 1 GNIWSAEK 8 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 GNIWS(1)AEK 82.417 0.041367 8932000.0 4741.3 6322.7 5549.3 5412.9 4727.6 4823.5 5365.3 4784.1 3184.6 5373.8 True False 4851.763065036185 5582.435344656518 4795.735540122971 4467.638627717179 4299.989414725573 4774.979969387589 4960.591101372192 4657.210127053105 5404.033606018667 6063.579575244666 0.8001483290240182 0.9206501333713043 0.7909083208377722 0.7367988780021757 0.7091503230667288 0.7874853310876058 0.8180961492819251 0.7680628363593606 0.8912282817366365 1.0 12.565954010839823 -8.529128320795008 3.0855215800261018 0.9996099830153201 0.7920907809274187 0.6091031987493227 0.05296368371851248 0.1738277276037687 4.2093218532073156 0.05636689839630119 0.015006855088131306 2.9571385930478877e-09 8.529128320795008 -0.20751920208790142 GNIWS(ph)AEK ddPTM_A459_Selumetinib_30min_R2 1 GNIWSAEK 8 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 GNIWS(1)AEK 86.014 0.03713 0.0 37093.0 36493.0 35738.0 31073.0 35626.0 29995.0 37371.0 35129.0 30393.0 35162.0 True False 35031.519555043924 39291.89575651056 33438.65598859231 26840.803796085183 31150.343379519043 34126.53898250002 39108.82554923165 35231.21957408099 36472.449251373386 34146.78169815241 1.0259098460496905 1.1506763976716594 0.9792623001540901 0.7860419770551164 0.9122482948723833 0.9994071852559538 1.1453151250077465 1.031758128350563 1.0681079573993004 1.0 15.059461991830284 -7.014290171754682 23.93724900478076 1.065144590546581 0.9695026250539909 0.17697389583901957 0.09210396250230017 738.8717613306738 1237671.9086105244 0.03860195350590479 0.031135458614619988 9.676311221813911e-08 7.014290171754682 -0.09564196549259019 GNKHDDGTQS(ph)DSENAGAHR ddPTM_A459_Selumetinib_30min_R1 4 GNKHDDGTQSDSENAGAHR 19 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 GNKHDDGT(0.002)QS(0.895)DS(0.103)ENAGAHR;GNKHDDGT(0.006)QS(0.978)DS(0.016)ENAGAHR;GNKHDDGT(0.067)QS(0.735)DS(0.198)ENAGAHR;GNKHDDGTQS(0.997)DS(0.003)ENAGAHR 119.72 0.00018907 24526300.0 5078.02 5546.82 4589.08 4935.5 4989.68 4799.32 5199.9400000000005 5328.0 3280.63 4079.59 True False 5196.327985893122 4897.395735753342 3965.9081420120597 4073.607575809298 4538.364324999555 4751.043198233906 4807.704339304291 5186.68413221691 5566.9895022649625 4603.245115071716 1.1288401673157842 1.0639007077243252 0.8615461577370886 0.884942572897475 0.9859054235761351 1.032107367621654 1.0444163235112431 1.1267451553329035 1.2093619529487585 1.0 12.16843555035733 -7.3847602175833496 1.764566208506651 1.123982435078211 0.9800314367886575 0.2656517981233776 0.08771884726028654 0.4792352357408668 2.905053810575362 0.05464331424583667 0.030478695291547276 4.123251089624022e-08 7.3847602175833496 -0.1439509982895536 GNKHDDGTQS(ph)DSENAGAHR ddPTM_A459_Selumetinib_30min_R2 6 GNKHDDGTQSDSENAGAHR 19 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 GNKHDDGT(0.01)QS(0.97)DS(0.02)ENAGAHR;GNKHDDGT(0.004)QS(0.967)DS(0.03)ENAGAHR;GNKHDDGTQS(0.899)DS(0.101)ENAGAHR;GNKHDDGT(0.003)QS(0.955)DS(0.042)ENAGAHR;GNKHDDGT(0.007)QS(0.975)DS(0.018)ENAGAHR;GNKHDDGT(0.011)QS(0.985)DS(0.004)ENAGAHR 103.31 0.00043301 57352260.0 23362.2 23860.59 23487.0 26265.600000000002 28530.9 23509.8 21601.699999999997 25313.1 16073.460000000003 25464.699999999997 True False 22063.82245029647 25690.62052911073 21975.87199071207 22688.179969312747 24946.593272517817 26748.061549284193 22606.221852956496 25386.756930190702 19288.60112999639 24729.467945763656 0.8922077296077116 1.038866690761607 0.8886512252875501 0.9174552408111717 1.0087800241893743 1.0816270535196184 0.9141410523888409 1.026579180185704 0.7799844773166935 1.0 14.593943580042946 -12.248041637892364 2.2097449909947176 2.7422986439478207 0.9564993765937173 0.024804813893103073 0.08561467648336836 6900747.398821254 1356571.9967134565 58961467.63528408 0.021260673883667307 5.648828141946927e-13 12.248041637892364 -1.7857992673541034 GNKHDDGTQSDS(ph)ENAGAHR ddPTM_A459_Selumetinib_30min_R2 2 GNKHDDGTQSDSENAGAHR 19 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 GNKHDDGTQS(0.107)DS(0.892)ENAGAHR;GNKHDDGT(0.001)QS(0.399)DS(0.6)ENAGAHR 79.34100000000002 0.0038347 1469600.0 1558.54 1443.4 1700.79 2037.0 2630.88 1290.6399999999999 1732.93 2501.79 703.85 2333.6 True False 1471.9225861299485 1554.1041387374923 1591.3630230801373 1759.5570859790023 2300.365334034384 1468.4139447365842 1813.5146787356507 2509.0697947063695 844.6396672121595 2266.222904579047 0.6495047698775949 0.6857684368105743 0.7022093986715462 0.7764271918811277 1.0150657860647117 0.6479565367420658 0.8002366735731642 1.1071593132505346 0.37270811512208774 1.0 11.146074055579948 -5.797675337759123 3.581484968799763 0.8245775080128103 0.6759962927811557 0.09768944105624955 0.19610529050449713 0.5421996581619997 14.44832241158207 0.053694164572829446 0.08856869928499943 1.5933994474994338e-06 5.797675337759123 -0.14858121523165457 GNKS(ph)PSPPDGS(ph)PAATPEIR ddPTM_A459_Selumetinib_30min_R2 2 GNKSPSPPDGSPAATPEIR 19 1 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 2 GNKS(0.997)PS(0.403)PPDGS(0.577)PAAT(0.023)PEIR;GNKS(0.87)PS(0.13)PPDGS(0.639)PAAT(0.361)PEIR 86.51899999999998 0.0070205 17839800.0 96456.0 85639.0 100668.0 100954.0 109027.0 73521.0 76525.0 83492.0 71487.0 89735.0 True False 91095.3616639613 92207.23592721342 94191.13047903107 87203.89104463616 95330.05354625336 83647.85039281164 80083.56413141085 83734.94789715542 85786.39751366865 87144.11739046998 1.0453414916785126 1.0581005200162499 1.0808661938359565 1.000685917259318 1.0939356137959875 0.9598794835227663 0.9189784294053649 0.9608789486266873 0.9844198332892885 1.0 16.411115658954472 -6.777159079567183 24.923648895570444 0.9595204320756716 1.0542467642989708 0.6916793609612599 0.030250497160207532 125.90275366916833 199618.0127408689 0.01037292736861233 0.009177803446559855 1.6704786155368296e-07 6.777159079567183 0.09472633222329918 GNKS(ph)PSPPDGSPAATPEIR ddPTM_A459_Selumetinib_30min_R1 4 GNKSPSPPDGSPAATPEIR 19 1 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 GNKS(0.962)PS(0.036)PPDGS(0.001)PAATPEIR;GNKS(0.826)PS(0.135)PPDGS(0.039)PAATPEIR;GNKS(0.846)PS(0.154)PPDGSPAATPEIR;GNKS(0.877)PS(0.123)PPDGSPAATPEIR 171.33 1.4147e-08 78557100.0 11044.43 12227.980000000001 13431.02 13850.989999999998 12888.710000000001 11993.08 12642.42 11694.300000000001 6150.33 10482.49 True False 11301.743730280214 10796.322416966326 11607.161255311905 11432.174611783767 11722.928456186573 11872.440504045384 11688.792080929263 11384.129175560103 10436.660807669645 11828.019699599252 0.955505994859235 0.9127751467417762 0.9813275214366755 0.9665332745574564 0.9911150601637704 1.0037555571916774 0.9882290001026371 0.9624712728493183 0.8823675537185022 1.0 13.529920930934873 -5.27353545543726 24.83943560196961 0.9728393538965512 0.9341405697638593 0.16474137908282627 0.034032010969555916 1105.0848501632968 2269305.037573192 0.009156939831601848 0.019298361248202077 5.326777351842336e-06 5.27353545543726 -0.0386987841326919 GNKS(ph)PSPPDGSPAATPEIR ddPTM_A459_Selumetinib_30min_R2 1 GNKSPSPPDGSPAATPEIR 19 1 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 GNKS(0.956)PS(0.044)PPDGSPAATPEIR 101.16 0.00066351 50143000.0 77293.0 66797.0 64498.0 65600.0 63599.0 49483.0 59182.0 61357.0 46967.0 64048.0 True False 72997.36448839426 71920.11511379274 60348.26890011273 56665.166833688054 55609.12503772612 56298.83408804963 61934.080266908204 61535.53871180188 56361.71236762589 62198.76782331113 1.1736143181446752 1.1562948532693955 0.9702486240811854 0.911033591447624 0.8940550911827659 0.9051438807916338 0.9957444887468699 0.9893369413138007 0.9061548056343072 1.0 15.924598379956672 -5.279066332053559 3.796412382562226 0.9411312076369569 1.171740851347479 0.8419222117390299 0.038044849210836736 0.07982817775933335 2.585629273880532 0.010779082482361776 0.027711215781692288 5.259369311746873e-06 5.279066332053559 0.23060964371052206 GNKSPS(ph)PPDGSPAATPEIR ddPTM_A459_Selumetinib_30min_R2 1 GNKSPSPPDGSPAATPEIR 19 1 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 GNKS(0.329)PS(0.67)PPDGS(0.001)PAATPEIR 67.097 0.01173 93546000.0 52435.0 58187.0 67827.0 72921.0 68858.0 49457.0 54132.0 63605.0 41865.0 74974.0 True False 49520.87261393597 62649.755799306135 63463.084664453825 62989.034004258545 60207.44244166956 56269.25282405414 56649.24526052309 63790.0800196254 50239.16980583515 72809.30581415394 0.6801448257223907 0.860463578092887 0.8716342499740846 0.8651233973448164 0.8269196055151152 0.7728305083375145 0.7780495175317359 0.8761253703262856 0.6900102843182002 1.0 16.15183523373628 -10.628183515368049 4.603402261674757 1.0000145139461503 0.8092661834861404 0.42175420845791933 0.06899935117772091 95803928.4067951 4.596506766077588 14738.837724675077 0.016288831490039176 2.354054345082828e-11 10.628183515368049 -0.19074833046000983 GNLELRPGGAHPGT(ph)CSPSRPGS ddPTM_A459_Selumetinib_30min_R2 1 GNLELRPGGAHPGTCSPSRPGS 22 2 Q5JTU8;B1AMJ5;A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8 Q5JTU8 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 GNLELRPGGAHPGT(0.436)CS(0.436)PS(0.115)RPGS(0.012) 63.869 0.026012 26440000.0 15227.0 11157.0 16667.0 15754.0 18040.0 13576.0 14671.0 14896.0 11834.0 14429.0 True False 14380.744298510604 12012.7060245907 15594.663365657514 13608.278022834162 15773.653920353769 15445.970769342233 15353.230570034992 14939.344893834455 14201.130669586832 14012.397278955714 1.0262872235365526 0.8572912818159804 1.1129190141559933 0.9711598773517168 1.1256927423862846 1.1023075111165674 1.0956890719258285 1.0661519650367652 1.0134690293797597 1.0 13.774416176616949 -6.247075033791783 24.839821258306564 1.073703976675743 0.9909416024315216 0.2194246101611409 0.06892272966087384 1068.5920627019896 1847883.84652329 0.020052008693315006 0.025748563611580264 5.661414673697486e-07 6.247075033791783 -0.08276237424422139 GNLELRPGGAHPGTCS(ph)PSRPGS ddPTM_A459_Selumetinib_30min_R1 1 GNLELRPGGAHPGTCSPSRPGS 22 2 Q5JTU8;B1AMJ5;A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8 Q5JTU8 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 GNLELRPGGAHPGT(0.181)CS(0.412)PS(0.305)RPGS(0.102) 55.669 0.02821 12759000.0 881.44 1146.3 1171.3 1232.5 1338.2 738.35 1173.1 977.01 573.32 951.24 True False 901.9758370163231 1012.0906630995877 1012.2438934903562 1017.2670118903775 1217.1600462784 730.9228693681614 1084.6121225317713 951.096521024258 972.8821663639455 1073.3409198622458 0.8403442189943565 0.9429349467357314 0.9430777069603097 0.947757597857105 1.1339920278401499 0.6809792264902834 1.010501046276119 0.8861085079532076 0.9064055495888546 1.0 10.067892669494139 -7.379672596064611 0.0047647698817262964 1.8627749686051776 2.2690270005761814e-06 0.019811266807143624 0.11120863788909324 58687.09133129255 187.80472376151704 36478.406877952075 36931.205179448385 4.1718376954138315e-08 7.379672596064611 -1.862772699578177 GNLELRPGGAHPGTCSPSRPGS(ph) ddPTM_A459_Selumetinib_30min_R1 1 GNLELRPGGAHPGTCSPSRPGS 22 2 Q5JTU8;B1AMJ5;A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8 Q5JTU8 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 GNLELRPGGAHPGT(0.07)CS(0.225)PS(0.18)RPGS(0.524) 54.66 0.030569 6030400.0 1117.5 1009.2 1049.6 1236.4 878.56 781.47 997.26 890.85 458.23 873.55 True False 1143.535575723522 891.0423948356486 907.0700850401076 1020.4859501024448 799.0944031223663 773.6091213179885 922.0358753013675 867.2217641113809 777.5828422049651 985.6786515975613 1.1601504951640278 0.9039887324245799 0.9202492958226832 1.0353130286919259 0.8107047888550856 0.7848492204473981 0.9354325304773079 0.8798220015273857 0.78888067723155 1.0 9.94497356932874 -1.7647072273361084 1.0418201051966642 0.8812932816563191 199.99999233788537 0.4802565291869568 0.08119505816658208 1076.8725344554182 2.1370814267796225 0.02586890210899406 511135.1301140673 0.01719066878006463 1.7647072273361084 199.11869905622905 GNLLHFPS(ph)SQGEEEKEK ddPTM_A459_Selumetinib_30min_R2 2 GNLLHFPSSQGEEEKEK 17 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 GNLLHFPS(0.5)S(0.5)QGEEEKEK;GNLLHFPS(0.5)S(0.5)QGEEEKEK 93.237 0.0031881 16499300.0 162993.0 134466.0 140714.0 140039.0 127393.0 118738.0 167266.0 171418.0 103891.0 119771.0 True False 153934.50157267603 144779.10982366352 131660.61443781928 120965.44661925064 111388.75243212997 135093.08170375376 175044.20043129128 171916.79800022242 124672.10295707663 116312.90002757013 1.3234516681828783 1.2447382000564506 1.1319519537954192 1.0400002630024503 0.9576646477366401 1.1614625864519936 1.5049422754466601 1.4780544372934754 1.0718682358321827 1.0 16.8276515864992 -7.0280497544886416 24.532357365324582 1.307789611994086 1.1314618768619997 0.08137773098638779 0.1750757475042102 1027.3806154254603 898545.4628142936 0.06832909559178382 0.053066999366647064 9.374546022772252e-08 7.0280497544886416 -0.17632773513208622 GNPS(ph)PPAAGEGQRPPPPLCVPGGGGGAPAR ddPTM_A459_Selumetinib_30min_R2 1 GNPSPPAAGEGQRPPPPLCVPGGGGGAPAR 30 1 Q92623 Q92623 TTC9 Tetratricopeptide repeat protein 9A 1 GNPS(1)PPAAGEGQRPPPPLCVPGGGGGAPAR 56.588 0.0025476999999999995 6805600.0 4256.9 3506.0 3641.2 5251.2 5218.3 2256.3 3149.6 3333.6 2022.5 4093.9 True False 4020.318539720875 3774.898926433181 3406.9291562388057 4535.977501174732 4562.730501806101 2567.084844347886 3296.0626408140006 3343.300224092811 2427.056513371587 3975.6984697703792 1.0112232027377752 0.9494932664375838 0.8569385183870789 1.1409259368295888 1.1476550690398877 0.6456940494524351 0.8290524711257512 0.8409340520952301 0.6104729852693693 1.0 11.956992626908596 -6.761518578782806 24.999999999997627 0.7780279537591241 1.0147814244750644 0.45810464343692003 0.1281314812817649 2.031382359725505 641003.6555521707 0.044011765150390465 0.04131824668175055 1.731734946880791e-07 6.761518578782806 0.23675347071594022 GNPT(ph)VEVDLFTSK ddPTM_A459_Selumetinib_30min_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798 P06733 ENO1 Alpha-enolase;Enolase 1 GNPT(0.554)VEVDLFT(0.129)S(0.317)K 144.15 0.0016009 3981100.0 839.38 1414.7 1588.3 1956.2 1394.0 1326.5 1335.4 1539.8 405.42 980.32 True False 858.9359208508369 1249.0662663238134 1372.6175839073949 1614.5863924218718 1267.912946130689 1313.1566143656344 1234.6697028632927 1498.959502024701 687.9681292947579 1106.1536211254327 0.7765069014346584 1.1291978279228316 1.240892365845943 1.45964029008841 1.1462358590307535 1.187137653655729 1.1161828513539593 1.3551097003141537 0.6219462795726323 1.0 10.111336043693473 -8.259792831057366 24.997018740984085 0.8109731392952072 1.1837332398480205 0.37519087172841514 0.18841768595355365 145.94863660738585 2215808.8149796417 0.1434391789650085 0.047710656975157056 5.4980308064336145e-09 8.259792831057366 0.3727601005528133 GNPTVEVDLFTSK ddPTM_A459_Selumetinib_30min_R1 2 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798 P06733 ENO1 Alpha-enolase;Enolase 0 ; 220.53 1.6327e-07 58571000.0 3578.8 3733.1000000000004 3563.8999999999996 3693.3 3971.2 3962.5 3279.0 3052.1000000000004 2914.6 2833.0 False True 3662.1790768674214 3296.026916528896 3079.94195510141 3048.3344868273703 3612.005661172307 3922.64084766214 3031.662390061956 2971.148393381988 4945.863326038435 3196.6431457568438 1.1456327496951044 1.0310900423476959 0.9634925810188288 0.9536048748117739 1.1299370922796956 1.2271125267357321 0.9483893734232175 0.9294588910638423 1.5472053340090428 1.0 11.642341983868967 -6.286122647753334 22.84225067927013 1.1225635547917414 1.0197173798284953 0.08322469951117883 0.1724730407481662 750.5128812974818 694531.8701400418 0.053282011760217324 0.06045775631796694 5.174606768542558e-07 6.286122647753334 -0.1028461749632461 GNPTVEVDLFTSK ddPTM_A459_Selumetinib_30min_R2 2 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8YEG5;A0A2R8Y798 P06733 ENO1 Alpha-enolase;Enolase 0 ; 188.96 0.0021125 26838000.0 54531.0 56308.0 56987.0 62524.0 61054.0 44875.0 45857.0 56558.0 43816.0 48073.0 False True 51500.385324888826 60626.64254124341 53320.51846275427 54008.12334008403 53383.850690314765 51056.123915308846 47989.44136392163 56722.574416319076 52580.42432132981 46685.00758134577 1.103146127483273 1.2986319523586922 1.1421336575740408 1.1568622591734226 1.1434902435711651 1.0936299801675446 1.027941171055889 1.2150062162351254 1.126280727912738 1.0 15.510671696920843 -6.0785954521898375 1.3620243770362939 1.1039829431037693 1.1966488555473611 0.22073407972669545 0.07176047127741211 0.6811189633780254 2.556687963439799 0.026032944765981017 0.04365747981380347 8.344581252488347e-07 6.0785954521898375 0.09266591244359179 GNRGS(ph)GGGGGGGGQGSTNYGK ddPTM_A459_Selumetinib_30min_R1 2 GNRGSGGGGGGGGQGSTNYGK 21 1 Q99729-3;Q99729-4 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 GNRGS(1)GGGGGGGGQGSTNYGK;GNRGS(1)GGGGGGGGQGSTNYGK 137.3 1.6655e-05 18684700.0 2049.1800000000003 2014.78 2659.3 3028.0 2449.9 1857.8400000000001 2297.7 2315.31 1155.97 1671.0 True False 2096.921906989823 1778.888620954189 2298.1816664892895 2499.2166425996475 2228.3069775649747 1839.1518163837534 2124.3826391111156 2253.9004576132015 1961.5966612916511 1885.4891269183504 1.1121368333834092 0.9434626779638928 1.2188782389031567 1.325500426875638 1.181819054669876 0.9754242494040096 1.1267010818477716 1.1953929754540584 1.0403648757697643 1.0 10.880723115552057 GNRGS(ph)GGGGGGGGQGSTNYGK ddPTM_A459_Selumetinib_30min_R2 3 GNRGSGGGGGGGGQGSTNYGK 21 1 Q99729-3;Q99729-4 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 GNRGS(1)GGGGGGGGQGSTNYGK;GNRGS(1)GGGGGGGGQGSTNYGK;GNRGS(1)GGGGGGGGQGSTNYGK 172.77 5.2099e-10 1517320.0 5076.789999999999 7109.299999999999 8068.4 6625.0 6841.6 4287.46 3285.0 3055.24 2237.52 4871.2 True False 4794.642335800594 7654.560449997545 7549.287928209707 5722.663571237546 5982.097043319972 4878.018697313205 3437.7590091040097 3064.130242577788 2685.086521532359 4730.555799102437 1.0135473587924524 1.6181101703630472 1.5958564381889522 1.2097232998125398 1.2645653697721944 1.031172425497813 0.7267135522968107 0.6477315505208009 0.5676048725694811 1.0 12.207793982286347 -6.913791985525336 1.4935437346501808 0.6907433329042261 1.3957433662480367 0.6801765713917212 0.19528516799632845 0.2162474239649298 0.9918157779283154 0.09416921178789671 0.07508358562806262 1.219573599475288e-07 6.913791985525336 0.7050000333438107 GNS(ph)LPCVLEQK ddPTM_A459_Selumetinib_30min_R1 2 GNSLPCVLEQK 11 0 Q08495;Q08495-4 Q08495 DMTN Dematin 1 GNS(1)LPCVLEQK;GNS(1)LPCVLEQK 113.54 0.0070392 13493000.0 5238.9 6045.200000000001 5508.799999999999 6084.1 5353.700000000001 4716.4 5538.2 5615.6 3152.8999999999996 4726.0 True False 5360.956176875134 5337.425173662764 4760.735217672391 5021.626147701622 4869.458780272506 4668.957298148567 5120.4491151696 5466.656045960456 5350.241021295056 5332.628135138319 1.0053122102308527 1.000899563667835 0.8927558976600017 0.9416794159361294 0.913144261492031 0.8755452620788198 0.9602111726916404 1.0251335565551603 1.0033028528729917 1.0 12.380631011464716 -7.614133644181396 5.10996552972889 1.0097614572695885 0.9365243353484635 0.3939537924749039 0.039386243824257504 0.22810906984046528 9.856342314254304 0.02091517734994333 0.011775343139131022 2.431455669136009e-08 7.614133644181396 -0.07323712192112508 GNS(ph)LPCVLEQK ddPTM_A459_Selumetinib_30min_R2 4 GNSLPCVLEQK 11 0 Q08495;Q08495-4 Q08495 DMTN Dematin 1 GNS(1)LPCVLEQK;GNS(1)LPCVLEQK;GNS(1)LPCVLEQK;GNS(1)LPCVLEQK 141.73 0.0009801 18436600.0 139749.0 106544.0 108227.0 133442.0 127497.0 91153.0 95978.0 105947.0 80888.0 102969.0 True False 131982.31003957163 114715.58220704389 101263.79264864777 115266.96939971026 111479.68702235821 103708.49834545169 100441.16717679898 106255.28822952992 97067.8601995555 99996.01742440852 1.319875665441806 1.1472015102377706 1.0126782571635677 1.1527156017672977 1.1148412696198697 1.0371262877929073 1.0044516748152192 1.0625952009524087 0.9707172615442755 1.0 16.6095830168721 -1.5228787452803376 0.6692156816081279 1.0355478903856805 28.81142569282648 0.7287816430925662 0.05187829268317171 136.62602477736965 0.8193282743216939 0.022321337356681105 5645.475562253318 0.029999999999999995 1.5228787452803376 27.7758778024408 GNS(ph)PEMR ddPTM_A459_Selumetinib_30min_R2 1 GNSPEMR 7 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 GNS(1)PEMR 86.882 0.034321 6947100.0 54865.0 44600.0 36899.0 51190.0 53699.0 46238.0 71823.0 117690.0 62296.0 99336.0 True False 51815.82294199676 48020.67658839699 34524.958512593555 44217.83369232454 46952.851544849036 52606.86479322673 75162.91181457453 118032.45841537166 74756.94069567195 96467.91157407634 0.5371301409609985 0.49778911769560386 0.357890597497618 0.45836831098359887 0.4867198924358864 0.545330192546261 0.7791493626029004 1.2235411391148052 0.7749410086302859 1.0 16.557761513520582 -7.373205018124076 2.694305840447112 1.0011568621705669 0.4688625765283227 0.8088536836054265 0.11373377635555182 0.10907108232639742 1.5363308284369055 0.052394428701383826 0.03241493620257015 4.2344302340175276e-08 7.373205018124076 -0.5322942856422441 GNS(ph)PNSEPPTPK ddPTM_A459_Selumetinib_30min_R2 1 GNSPNSEPPTPK 12 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 GNS(0.998)PNS(0.002)EPPTPK 143.64 0.00080925 5189500.0 34991.0 31191.0 29926.0 35458.0 31130.0 24213.0 28532.0 29426.0 23841.0 29782.0 True False 33046.34030007121 33583.24940512757 28000.593740965196 30628.559231538253 27219.171094269 27548.12096627017 29858.794535085424 29511.62478826345 28609.866173197526 28922.116277071123 1.142597588070334 1.1611615513679303 0.9681377902198501 1.0590013171276806 0.9411196204839207 0.952493265097263 1.032386228208234 1.020382620190891 0.9892037601646342 1.0 14.819885499982716 -5.257226573062409 24.99150748831028 0.9961984578063088 1.151879587538223 0.7685495646921354 0.03435919352957359 158.99705434769407 943204.8647040703 0.009026327263221333 0.022194582399830316 5.530614996762746e-06 5.257226573062409 0.15568112973191428 GNS(ph)PPSSGEACR ddPTM_A459_Selumetinib_30min_R1 3 GNSPPSSGEACR 12 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GNS(0.993)PPS(0.005)S(0.002)GEACR;GNS(0.995)PPS(0.002)S(0.003)GEACR;GNS(0.333)PPS(0.333)S(0.333)GEACR 139.64 0.0011415 73343300.0 5262.98 5694.74 4193.03 4371.700000000001 4769.67 3767.9 5037.25 4984.34 2493.93 4399.900000000001 True False 5385.597194023609 5027.997193387201 3623.63955666513 3608.2646619725474 4338.2541906536335 3729.9983469794734 4657.28617698676 4852.139111781918 4232.017060559607 4964.670023655325 1.0847845210986184 1.012755564706242 0.7298852772489323 0.7267884159027954 0.8738252834494563 0.751308411074055 0.9380857448321916 0.9773336573554279 0.8524266548220077 1.0 12.277482117006631 -9.598212728740775 10.730859194224323 1.0 0.8779871454716933 0.08166651318215046 0.11658586242696513 0.0 0.0 0.121499012601451 0.029467838962590222 2.5222450085980386e-10 9.598212728740775 -0.12201285452830668 GNS(ph)PPSSGEACR ddPTM_A459_Selumetinib_30min_R2 6 GNSPPSSGEACR 12 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GNS(0.768)PPS(0.074)S(0.157)GEACR;GNS(0.999)PPSS(0.001)GEACR;GNS(0.984)PPS(0.008)S(0.008)GEACR;GNS(0.865)PPS(0.091)S(0.045)GEACR;GNS(0.333)PPS(0.333)S(0.333)GEACR;GNS(0.701)PPS(0.149)S(0.149)GEACR 127.03 0.0026515 289609400.0 175063.69999999998 137069.36000000002 192869.9 212868.15 211259.37999999998 140960.83 154418.06 175736.90000000002 173317.77 165771.11000000002 True False 165334.36038951686 147582.1391645414 180460.8606148698 183875.1407519592 184719.0880015801 160376.90481748816 161598.80576358107 176248.26528419027 207986.16690310984 160984.86732923042 1.0270180243177223 0.9167454159695703 1.1209802735421648 1.1421889759111075 1.14743137703627 0.9962234803691274 1.0038136406516713 1.0948126256099877 1.2919609796475902 1.0 17.296565554980774 -5.2708201476276155 24.818804786391834 1.0991680088332447 0.9718817182702083 0.252260455703496 0.0880047643253663 759.9642469857903 2010649.4114248685 0.023665931062896807 0.05039104306801139 5.3601859046481145e-06 5.2708201476276155 -0.12728629056303642 GNS(ph)RPGTPS(ph)AEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R2 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 2 GNS(1)RPGT(0.01)PS(0.824)AEGGS(0.11)T(0.049)S(0.005)S(0.001)T(0.001)LR 158.44 4.3954e-05 15639000.0 10707.0 8592.8 11352.0 10781.0 13238.0 10989.0 11927.0 13274.0 11703.0 9282.9 True False 10111.947803516983 9251.840129793212 10621.624679123071 9312.60920173766 11574.92409077844 12502.63500179006 12481.629132902146 13312.625142370998 14043.927009141018 9014.878557129254 1.12169539938174 1.0262856089699137 1.1782326974025792 1.0330265840767152 1.283980035607315 1.3868888995628874 1.3845587662444188 1.4767392658709695 1.557860920714748 1.0 13.138092341354923 -6.464322688883951 3.1677576001170693 1.3913409111123303 1.0917345994284613 0.43686485465592306 0.14340138908983624 0.21465188672636037 4.2612918020393336 0.04574904126976747 0.0505316050092616 3.4330277276132397e-07 6.464322688883951 -0.299606311683869 GNS(ph)RPGTPSAEGGST(ph)SSTLR ddPTM_A459_Selumetinib_30min_R2 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 2 GNS(0.999)RPGT(0.002)PS(0.149)AEGGS(0.205)T(0.58)S(0.057)S(0.006)T(0.001)LR 183.25 1.0797999999999998e-11 25700000.0 17603.0 12092.0 18082.0 20029.0 19154.0 14627.0 17713.0 22353.0 17296.0 15217.0 True False 16624.69573039221 13019.417518091846 16918.62380619303 17301.01564804783 16747.7032810674 16641.736479314146 18536.68959764364 22418.04352926164 20755.683290618035 14777.645671485849 1.1249894671970875 0.8810210914187376 1.1448795147956685 1.1707558857924805 1.133313360827352 1.1261426108913375 1.254373667478781 1.5170240258580763 1.4045324777726325 1.0 13.851128821657076 -7.341045945442367 3.0758474047744553 1.3503160563279881 1.0915459467444877 0.2937178741781754 0.14569850646388238 0.27492761498635665 5.069661069288343 0.06638108045099664 0.042788004360044526 4.559886728572262e-08 7.341045945442367 -0.25877010958350044 GNS(ph)RPGTPSAEGGSTSS(ph)TLR ddPTM_A459_Selumetinib_30min_R1 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 2 GNS(1)RPGTPSAEGGS(0.018)T(0.269)S(0.11)S(0.492)T(0.11)LR 147.02 0.00077634 8038900.0 2078.3 1992.0 1322.3 1382.3 1773.7 1550.9 2210.2 1508.7 930.45 1720.8 True False 2126.720346332168 1758.775713944325 1142.738922873984 1140.9072539846406 1613.26914817217 1535.299354104533 2043.4828345577707 1468.6843750517376 1578.9056926207577 1941.6814420114285 1.0952982813334478 0.9058003418533846 0.5885305890806665 0.5875872474749261 0.8308619082752063 0.7907060967292782 1.0524295027720325 0.7563982140810372 0.8131641259264115 1.0 10.923090812026567 -7.054514770179825 24.99344453986556 0.890393560342711 0.7863855558961069 0.08956198707734175 0.15890903716690435 893.9751471052281 409858.6365905797 0.06529488810144828 0.05057754650944544 8.820338040133318e-08 7.054514770179825 -0.10400800444660407 GNS(ph)RPGTPSAEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R1 2 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNS(0.9)RPGT(0.1)PSAEGGSTSSTLR;GNS(0.993)RPGT(0.007)PSAEGGSTSSTLR 254.24 9.4195e-38 20271000.0 2413.8 2813.6 1882.59 1695.8600000000001 2278.58 1838.35 2646.8999999999996 2524.1 1320.33 2252.77 True False 2470.0368435628093 2484.1824039928465 1626.9446183266539 1399.709886234821 2072.4828413159717 1819.857868088249 2447.242201968583 2457.1526685677013 2240.5035769122096 2541.934973338033 0.9717151970725638 0.977280076024389 0.640041793118796 0.5506474008643666 0.8153170175688705 0.7159340766685457 0.9627477601265696 0.9666465485310991 0.8814165588075654 1.0 11.311711409087302 -7.270347580948016 24.579108980359052 0.9499232784012348 0.7725496803135975 0.3107028958058621 0.1269093230004588 735.2812702858969 2028745.1555298714 0.05835079504862995 0.04001700453680455 5.3660216313163646e-08 7.270347580948016 -0.1773735980876373 GNS(ph)RPGTPSAEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R2 3 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNS(0.999)RPGT(0.001)PSAEGGSTSSTLR;GNS(0.99)RPGT(0.009)PS(0.001)AEGGSTSSTLR;GNS(0.887)RPGT(0.088)PS(0.004)AEGGS(0.01)T(0.01)SSTLR 89.913 0.005307500000000001 31253300.0 19718.2 13229.0 25884.1 22119.9 23550.3 21480.199999999997 14592.7 21744.0 23471.5 19254.3 True False 18622.341382208702 14243.621762060615 24218.745186477216 19107.131461044148 20591.70077164674 24438.902572158593 15271.289464886493 21807.27144008701 28166.455848504946 18698.37833032069 0.9959335003940588 0.7617570631226139 1.295232386393898 1.0218603519247782 1.1012559703242233 1.30700652968013 0.8167173214226315 1.16626538702156 1.5063582173236447 1.0 14.190625533285116 -5.257069937704066 24.96860352683275 1.1448997874653253 0.8788452838578694 0.2518075791794354 0.18792277151374945 499.6811338965513 2855335.8576245294 0.04748833421578187 0.11688562064964185 5.532610062639745e-06 5.257069937704066 -0.26605450360745586 GNS(ph)SDHEGCWNEESWTFSQSGTSGSK ddPTM_A459_Selumetinib_30min_R2 1 GNSSDHEGCWNEESWTFSQSGTSGSK 26 0 C9JA69;Q8WY36-2;Q8WY36 C9JA69 BBX HMG box transcription factor BBX 1 GNS(0.499)S(0.499)DHEGCWNEES(0.002)WTFSQSGTSGSK 98.766 1.7524000000000004e-06 2763900.0 6186.4 3996.0 6203.6 8750.7 7953.7 6320.2 3666.9 4623.3 5662.6 6732.2 True False 5842.584654121366 4302.480350834847 5804.467129968982 7558.839564200512 6954.485099019828 7190.7501809367095 3837.4181158245033 4636.753037571485 6795.278226263514 6537.823893643749 0.8936589221685347 0.658090585006096 0.8878286145964016 1.1561705679391918 1.0637308701112564 1.099869053971881 0.5869564825010576 0.7092196291918268 1.0393792088633755 1.0 12.674594801077658 -10.45468265257006 17.772863191127144 0.9999999999925919 0.8954875766575559 0.02531607594867813 0.18575374490450783 0.0 0.0 0.19556587323378005 0.04743169130053112 3.5100826883797325e-11 10.45468265257006 -0.10451242333503608 GNSPPS(ph)SGEACREEK ddPTM_A459_Selumetinib_30min_R1 1 GNSPPSSGEACREEK 15 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 GNS(0.19)PPS(0.405)S(0.405)GEACREEK 73.834 0.023098 76783000.0 1976.2 1976.2 3903.1 4701.0 3287.0 2644.7 2599.2 1933.5 1377.1 1594.2 True False 2022.2416149841833 1744.825585289545 3373.080458193637 3880.0585986991196 2989.6914303669855 2618.096719195471 2403.1402513720745 1882.21729910687 2336.8381205954593 1798.8310988230016 1.1241976060494852 0.969977440589729 1.8751512915251947 2.156988836382633 1.6620189812835564 1.4554433270074802 1.3359454664445596 1.0463557697765116 1.299087013852764 1.0 10.81284401581517 -7.393594494804951 2.1899484098753885 1.1299004781234763 1.5708008207789619 0.25256604586765175 0.3269646905253178 0.5251630177323571 4.92130782026056 0.1973714785169412 0.11529402516738256 4.040224568019485e-08 7.393594494804951 0.4409003426554856 GNSRPGT(ph)PS(ph)AEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R1 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 2 GNS(0.019)RPGT(0.984)PS(0.946)AEGGS(0.035)T(0.009)S(0.007)STLR 128.44 0.018249 21139000.0 3772.0 5058.3 3244.1 3031.5 4343.1 3280.4 4773.5 4625.6 2422.5 5246.9 True False 3859.880260965659 4466.071884460125 2803.569038565751 2502.1054333027832 3950.267371836582 3247.4021543648882 4413.431051833102 4502.9140619336595 4110.805567600395 5920.3907241339875 0.6519637707746506 0.7543542466301336 0.4735445968350081 0.422625051266153 0.6672308561888729 0.5485114590709562 0.7454628009334101 0.7605771767018517 0.6943470049777345 1.0 12.53147667625434 -8.636246263347582 0.5662693191641588 1.0006787698244641 0.5816009469988694 0.5830888109439794 0.10113895815433732 0.8014469710072455 0.5859108397352406 0.1215811728305619 0.05168861060197076 2.310754123245876e-09 8.636246263347582 -0.4190778228255947 GNSRPGT(ph)PSAEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R1 5 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNS(0.02)RPGT(0.876)PS(0.103)AEGGSTSSTLR;GNS(0.021)RPGT(0.976)PS(0.003)AEGGSTSSTLR;GNS(0.313)RPGT(0.649)PS(0.037)AEGGSTSSTLR;GNSRPGT(0.983)PS(0.013)AEGGSTS(0.001)S(0.001)T(0.002)LR;GNSRPGT(0.88)PS(0.119)AEGGS(0.001)TSSTLR 208.89 1.0107999999999998e-15 112833300.0 7710.550000000001 9911.32 7527.6900000000005 8396.11 8823.71 7566.24 9202.9 8437.5 4529.93 7643.08 True False 7890.190812881435 8750.898046752334 6505.471044641351 6929.887003004396 8025.606988452524 7490.130495196254 8508.717843702705 8213.71009113743 7686.960357003114 8624.143767903719 0.914895556617015 1.014697607352089 0.7543323974784159 0.8035449303147287 0.9305975415578349 0.8685071465380834 0.9866159554725198 0.9524087622131496 0.8913302658069663 1.0 13.07416551325261 -7.250812205788216 24.470777263559135 0.9536228099384232 0.8801317248209892 0.21570272629451437 0.07128160124611965 954.8657646050427 2198735.4304562975 0.029106704818055742 0.022286806426744094 5.612906324555137e-08 7.250812205788216 -0.07349108511743396 GNSRPGT(ph)PSAEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R2 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNS(0.039)RPGT(0.958)PS(0.002)AEGGSTSSTLR 64.68 0.024579 23895000.0 9983.3 11289.0 13531.0 13919.0 14360.0 11194.0 12411.0 13217.0 10989.0 12559.0 True False 9428.468152316336 12154.830000143804 12660.43019143889 12023.208188385732 12555.968419971172 12735.871890985343 12988.136091929953 13255.45928180786 13187.107058314157 12196.389037799221 0.7730540673223439 0.9965925129539065 1.0380474214295319 0.9858006456766207 1.0294824460795353 1.0442329981041232 1.064916513541585 1.0868347377839747 1.0812304377504267 1.0 13.57416645452041 -4.201368572592461 1.3993143923279614 1.0460891395161371 2.6101107684401553e-15 0.8698041593846366 0.03090075700012875 1.9356557568255186 1.0941738264245424 0.009613236656248029 4.256792538685469 6.289721666316693e-05 4.201368572592461 -1.0460891395161345 GNSRPGTPS(ph)AEGGSTSSTLR ddPTM_A459_Selumetinib_30min_R1 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNS(0.002)RPGT(0.279)PS(0.711)AEGGS(0.002)T(0.002)S(0.002)S(0.001)T(0.001)LR 91.733 0.00082601 70192000.0 1798.2 2236.5 1997.9 2049.4 1924.6 1902.7 1852.5 1710.8 727.37 1551.2 True False 1840.09456131189 1974.6495402793585 1726.5961536791447 1691.5107620025483 1750.520269815727 1883.5605655133754 1712.7644335436928 1665.4240265384176 1234.2937649971097 1750.3116299675328 1.0512953978064024 1.1281702677802508 0.9864507120433017 0.9664054863384098 1.0001192015436693 1.0761286923222435 0.9785482791858405 0.9515014343870355 0.7051851475271321 1.0 10.7733960907103 -7.899714982292656 2.9496061095668904 0.84783554736849 1.029073175755703 0.41268744660708123 0.08162936840916593 0.2330587314544384 3.9647000004246307 0.05338415071136024 0.021624997346991293 1.2597518874155587e-08 7.899714982292656 0.18123762838721302 GNSRPGTPSAEGGSTS(ph)STLR ddPTM_A459_Selumetinib_30min_R2 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNSRPGT(0.102)PS(0.001)AEGGS(0.012)T(0.012)S(0.392)S(0.392)T(0.089)LR 148.06 9.4644e-05 12625000.0 13584.0 9777.8 14162.0 16943.0 15264.0 14053.0 13144.0 13476.0 13375.0 14074.0 True False 12829.055661060487 10527.725819417661 13250.832338419734 14635.334171694763 13346.399858108633 15988.67318956736 13755.222044341886 13515.212928928104 16050.37372872434 13667.647051356496 0.9386440557657816 0.7702661460205615 0.9695035501450563 1.0708012956950206 0.9764957938962888 1.169818998799834 1.0064074666734022 0.9888470837843838 1.1743333485577068 1.0 13.738477277246924 -5.50491437073982 4.44681107455722 1.0530746952041579 0.8547739398423634 0.523946286689114 0.07621225955557921 0.1424615022591547 6.91206809781407 0.019632106841483865 0.039590649589628615 3.126695792765532e-06 5.50491437073982 -0.19830075536179448 GNSRPGTPSAEGGSTSST(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 GNSRPGTPSAEGGSTSSTLR 20 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 GNS(0.008)RPGT(0.029)PS(0.001)AEGGS(0.023)T(0.039)S(0.297)S(0.067)T(0.537)LR 102.5 0.0066027 9916300.0 8988.8 7690.0 8960.1 12376.0 12269.0 11104.0 9271.6 11706.0 9740.1 11158.0 True False 8489.23848101741 8279.798272752749 8383.616921019251 10690.36745020919 10727.65853374836 12633.475207923997 9702.747771326867 11740.062521967378 11688.392161132564 10835.83954803437 0.7834407701761664 0.7641122993792124 0.7736933427128908 0.9865749121532934 0.9900163698616565 1.1658972202311468 0.8954311041904413 1.083447431085027 1.0786789624669966 1.0 13.403523315617209 -5.826186502422172 3.1351614256338824 1.0367652000566647 0.7678813418745164 0.7549368389556881 0.06691811869954067 0.11534281968308369 2.288605787578317 0.019145125548083286 0.0316572251833025 1.4921534850139358e-06 5.826186502422172 -0.2688838581821483 GNSS(ph)DHEGCWNEESWTFSQSGTSGSK ddPTM_A459_Selumetinib_30min_R2 1 GNSSDHEGCWNEESWTFSQSGTSGSK 26 0 C9JA69;Q8WY36-2;Q8WY36 C9JA69 BBX HMG box transcription factor BBX 1 GNS(0.41)S(0.583)DHEGCWNEES(0.007)WTFSQSGTSGSK 84.47 6.5294e-05 5494000.0 16396.0 16483.0 26252.0 26487.0 23319.0 18189.0 18158.0 21728.0 21233.0 23114.0 True False 15484.775958388384 17747.193098801512 24562.974901016434 22879.424907376444 20389.458745494965 20694.369646697553 19002.382979394402 21791.224882735973 25480.193299589082 22446.638762615734 0.6898483163625307 0.7906392260545921 1.0942829864543193 1.0192806659980427 0.9083524246602593 0.9219362357790273 0.8465580606679676 0.9708012461548883 1.135145157769708 1.0 14.454211806539995 -5.068621332658636 5.0814839570789205 0.9764868441158944 0.7101883325011791 0.6019939143994455 0.08167586400001291 0.13745461081019156 6.716740079628154 0.022367116397736114 0.06631977582849857 8.538442681307877e-06 5.068621332658636 -0.2662985116147153 GNVFSS(ph)PTAAGT(ph)PNKETAGLK ddPTM_A459_Selumetinib_30min_R1 1 GNVFSSPTAAGTPNKETAGLK 21 1 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4;E9PGZ1 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 2 GNVFS(0.453)S(0.528)PT(0.051)AAGT(0.965)PNKET(0.003)AGLK 75.868 0.0098875 16102000.0 4829.6 4921.0 5806.6 5873.3 4479.3 4125.6 5578.9 5099.9 3535.8 4325.0 True False 4942.120283234294 4344.847032289168 5018.095613370699 4847.638410495541 4074.1481058846484 4084.1002097450873 5158.079081401842 4964.634085190134 5999.994355385542 4880.1558790675435 1.0126972182246339 0.8903090679798823 1.0282654361297803 0.9933367971479191 0.8348397483285104 0.8368790487334681 1.056949656777644 1.0173105548707866 1.2294677678476056 1.0 12.252711514902318 -7.423947622711839 6.444896710741973 1.0821338258023896 0.9335458332612925 0.4064955236824954 0.08513532924991259 0.2541943489137714 13.96226107128455 0.03700437888525128 0.024674712769871564 3.767492333932664e-08 7.423947622711839 -0.1485879925410971 GNVFSS(ph)PTAAGTPNK ddPTM_A459_Selumetinib_30min_R2 2 GNVFSSPTAAGTPNK 15 0 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4;E9PGZ1 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 1 GNVFS(0.076)S(0.9)PT(0.023)AAGTPNK;GNVFS(0.076)S(0.894)PT(0.03)AAGTPNK 249.36 5.5661e-28 18383100.0 100429.0 93794.0 131161.0 112287.0 150828.0 105590.0 119942.0 125270.0 111974.0 121509.0 True False 94847.55822914034 100987.69820475591 122722.24405729916 96993.31689412065 131879.63822057177 120134.06404941417 125519.54066056423 125634.51496043513 134371.92881496673 118000.71945170376 0.803787965614568 0.8558227328951917 1.0400126764271795 0.8219722502100406 1.1176172385503842 1.018079081276988 1.0637184353095224 1.06469278784233 1.1387382165069213 1.0 16.848436130178513 -4.85739417700343 0.5016866882896577 1.0792127842226982 0.6266728357313742 0.5672225105585366 0.07605717434938472 2.996476900604155 0.6133131585215219 0.04709352254408006 0.7967096367959513 1.3886916462764629e-05 4.85739417700343 -0.45253994849132395 GNVFSS(ph)PTAAGTPNKET(ph)AGLK ddPTM_A459_Selumetinib_30min_R2 1 GNVFSSPTAAGTPNKETAGLK 21 1 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4;E9PGZ1 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 2 GNVFS(0.184)S(0.665)PT(0.251)AAGT(0.439)PNKET(0.461)AGLK 72.676 0.014916 9595200.0 96139.0 100270.0 102160.0 111390.0 108810.0 91739.0 100090.0 100700.0 70734.0 106160.0 True False 90795.97925490979 107960.38658113359 95587.13682339767 96218.48984153231 95140.31502625799 104375.21452627337 104744.38332457251 100993.02032821756 84882.77647309085 103094.88496319494 0.8807030463957947 1.047194403676532 0.92717632749212 0.9333003269355457 0.9228422444064345 1.0124189436123383 1.015999807962989 0.979612328625928 0.8233461485833575 1.0 16.65361322982669 -4.502058026589632 17.90254825550067 0.9619097356554311 0.689130294972141 0.13886200807028048 0.061045626499609866 4556561.148899088 99163900.33486487 0.015081563385024144 35072659.611282475 3.147327767892248e-05 4.502058026589632 -0.2727794406832902 GNVFSSPTAAGT(ph)PNKETAGLK ddPTM_A459_Selumetinib_30min_R2 1 GNVFSSPTAAGTPNKETAGLK 21 1 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4;E9PGZ1 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 1 GNVFSSPT(0.002)AAGT(0.996)PNKET(0.002)AGLK 85.00200000000002 0.0015704 14043000.0 75894.0 80270.0 99991.0 100670.0 92469.0 89754.0 63857.0 70336.0 56518.0 87753.0 True False 71676.11530775354 86426.45089126969 93557.68792196916 86958.57233456356 80852.21753665151 102116.79879430942 66826.47703024503 70540.66611524831 67823.17924486296 85219.3428803245 0.8410780098176769 1.0141647185972833 1.097845685730696 1.0204088578420687 0.9487542945525191 1.198281931576431 0.7841702924662421 0.827754166261411 0.795866019996289 1.0 16.378893306600055 -7.29047037989501 24.993093617924256 0.8375937827327821 1.0201261277891192 0.3873008337581382 0.1029735463159834 698.6787418767256 601496.999500138 0.04194354403187327 0.028284257577765235 5.1230620979725564e-08 7.29047037989501 0.1825323450563371 GNVFSSPTAAGTPNKET(ph)AGLK ddPTM_A459_Selumetinib_30min_R2 1 GNVFSSPTAAGTPNKETAGLK 21 1 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4;E9PGZ1 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 1 GNVFSSPT(0.025)AAGT(0.144)PNKET(0.83)AGLK 98.377 0.00045881 18058000.0 54492.0 51631.0 62745.0 63110.0 69168.0 58965.0 46905.0 49676.0 30959.0 56760.0 True False 51463.55278875945 55590.931680168695 58708.05501159064 54514.30912917759 60478.497470234455 67086.89351902377 49086.17544049426 49820.54893569547 37151.66506673473 55121.191319809186 0.9336436959457501 1.0085219558778058 1.065072318030478 0.9889900385659209 1.0971914071911575 1.2170798909223577 0.8905136892941918 0.9038365779621894 0.6739996755727473 1.0 15.750319448517047 -7.472982700831351 12.502007897085667 0.852754700636343 1.049987971942443 0.4383852532427285 0.10275970420396302 1.4966451557139806 374.28637620179177 0.04318145043401238 0.02905942699989464 3.365249738431406e-08 7.472982700831351 0.19723327130610002 GNVVPS(ph)PLPTR ddPTM_A459_Selumetinib_30min_R1 3 GNVVPSPLPTR 11 0 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 GNVVPS(0.912)PLPT(0.088)R;GNVVPS(0.993)PLPT(0.007)R;GNVVPS(0.83)PLPT(0.17)R 113.37 0.0071372 1713439000.0 15150.0 22960.2 10533.4 10839.7 14498.3 13886.0 18956.300000000003 15669.7 7801.2 16194.3 True False 15502.965523231638 20272.00911009261 9103.022135824569 8946.749881369684 13186.93132488277 13746.319447479224 17526.411029195307 15254.088653641018 13238.06662289544 18272.996150840132 0.8484085146878807 1.1093971094149533 0.49816801036244085 0.48961592327366316 0.7216622395160127 0.7522750693978126 0.9591427089743847 0.8347885879097986 0.7244606474831877 1.0 14.157425585904846 -7.093359126988296 7.3040896298080344 0.8655062008261034 0.7285922390401801 0.13245225975652686 0.17813869449129704 0.6919068279837362 47.34925290585566 0.07465807411023147 0.05785020390185882 8.065677870111381e-08 7.093359126988296 -0.1369139617859233 GNVVPS(ph)PLPTR ddPTM_A459_Selumetinib_30min_R2 4 GNVVPSPLPTR 11 0 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 GNVVPS(0.827)PLPT(0.173)R;GNVVPS(0.982)PLPT(0.018)R;GNVVPS(0.602)PLPT(0.398)R;GNVVPS(0.5)PLPT(0.5)R 104.9 0.012001 1288570100.0 333642.4 332068.0 314140.3 369548.0 363560.0 300874.0 364268.0 359794.0 322355.5 287295.0 True False 315099.8910843494 357536.54783309024 293928.8551080973 319214.9248941421 317886.34253236186 342316.6624377636 381207.1837833482 360840.94097289705 386835.60736521875 279000.04686794477 1.129390100903787 1.2814927877138245 1.053508264273585 1.1441393235508368 1.1393773804017409 1.226941236320966 1.3663337625307987 1.293336488734315 1.3865073203672769 1.0 18.089905838843052 -6.952264344979099 4.443413000839899 1.287649677733914 1.1521735623799678 0.16866562828974796 0.11231037381254327 0.2933675362122346 12.536152725427634 0.039130717721528714 0.03362513239500511 1.1161836458735571e-07 6.952264344979099 -0.1354761153539461 GNVVPS(ph)PLPTRR ddPTM_A459_Selumetinib_30min_R1 4 GNVVPSPLPTRR 12 1 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 GNVVPS(0.619)PLPT(0.381)RR;GNVVPS(0.693)PLPT(0.307)RR;GNVVPS(0.691)PLPT(0.309)RR;GNVVPS(0.952)PLPT(0.048)RR 120.32 0.0020851 898100000.0 12958.8 13733.7 15458.2 15790.1 16866.5 14964.900000000001 16217.800000000001 15444.9 8559.6 13728.3 True False 13260.714826564634 12125.75201937609 13359.061345814587 13032.655451886616 15340.928053022426 14814.366693042051 14994.478288974307 15035.251079894331 14525.016031551015 15490.461029966002 0.8560568210921569 0.7827883234668777 0.8624056650071122 0.8413342525232266 0.9903467703992601 0.9563541501046315 0.9679814086854984 0.9706135311795384 0.93767486993787 1.0 13.919092462072525 -6.25289754407285 22.84981321617544 0.9681930651231925 0.8337820454283895 0.8693345556716533 0.025598368620367785 63.84650261902419 170791.46371420022 0.007365954569155944 0.009331348859162713 5.586019609319368e-07 6.25289754407285 -0.13441101969480296 GNVVPS(ph)PLPTRR ddPTM_A459_Selumetinib_30min_R2 6 GNVVPSPLPTRR 12 1 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 GNVVPS(0.977)PLPT(0.023)RR;GNVVPS(0.775)PLPT(0.225)RR;GNVVPS(0.968)PLPT(0.032)RR;GNVVPS(0.994)PLPT(0.006)RR;GNVVPS(0.916)PLPT(0.084)RR;GNVVPS(1)PLPTRR 149.82 0.0010159 317523200.0 1726267.0 1796704.0 2047245.0 2123085.0 2046076.0 1321617.0 1123628.0 1278528.0 1025571.0 1817887.0 True False 1630327.9909343268 1934505.4194860803 1915527.485571817 1833917.1604740939 1789029.64072848 1503657.7453053747 1175878.9284266422 1282248.304808296 1230713.8568479659 1765399.8788723384 0.9234893524382194 1.0957888026602558 1.0850388676787344 1.0388111965009996 1.0133849345629473 0.851737763948328 0.6660694511759813 0.7263217360291999 0.6971303621217494 1.0 20.751563573174323 -6.860201546552723 2.952809327116826 0.7496003790353343 1.0416597979601168 0.6178441709899058 0.09629967166846756 0.15056187759175332 2.6431887464892725 0.03483396337822073 0.03061180282682063 1.3797438071355103e-07 6.860201546552723 0.2920594189247825 GNVVPSPLPT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GNVVPSPLPTR 11 0 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 GNVVPS(0.421)PLPT(0.579)R 110.98 0.019906 1241600000.0 8899.1 14611.0 6329.3 6156.8 8385.9 8460.1 10802.0 9576.4 4800.0 9168.2 True False 9106.431715365728 12900.337327530382 5469.815824356277 5081.630457449639 7627.396825650897 8374.9990751562 9987.196443259909 9322.402763468855 8145.249421870751 10345.027775830538 0.8802713644366826 1.2470084766393674 0.5287386310489764 0.49121477173043804 0.7373007584833228 0.8095675774523305 0.9654103072196052 0.9011481617525592 0.7873588740767609 1.0 13.3366498983094 -7.078417959045177 5.681899351354881 0.9044308261578962 0.773257403663576 0.09375043675055394 0.2007855191344942 0.6909861766222741 38.097208028478846 0.08541440318787603 0.066379327888284 8.347992322002742e-08 7.078417959045177 -0.13117342249432018 GNVVPSPLPT(ph)R ddPTM_A459_Selumetinib_30min_R2 2 GNVVPSPLPTR 11 0 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 GNVVPS(0.117)PLPT(0.883)R;GNVVPS(0.087)PLPT(0.913)R 117.03 0.013369999999999998 1168974800.0 401638.0 295763.0 445769.0 386375.0 510236.0 356498.0 383263.0 422245.0 398180.0 356028.0 True False 379316.5678443034 318447.07107206405 417088.70785659057 333750.0584659487 446135.5921122855 405602.36353336595 401085.4889212267 423473.663043577 477827.12607876415 345748.5465681646 1.0970879606272497 0.9210366152885099 1.2063353902613188 0.9652970685739372 1.290346977711241 1.1731137196650547 1.1600496745462163 1.2248024387865035 1.3820076203402352 1.0 18.399363661132007 -6.262841641279054 24.99992808132846 1.2124463565102137 1.0497602222223021 0.305321146371599 0.11612821771393543 151.67192674414224 2704053.80470415 0.03371064649026414 0.04029333251332915 5.459568994838953e-07 6.262841641279054 -0.16268613428791157 GNYACQAILT(ph)HS(ph)GKQYEVLNGIT(ph)VS(ph)IK ddPTM_A459_Selumetinib_30min_R1 1 GNYACQAILTHSGKQYEVLNGITVSIK 27 1 Q9HB29-2 Q9HB29-2 4 GNY(0.024)ACQAILT(0.924)HS(0.599)GKQY(0.519)EVLNGIT(0.944)VS(0.99)IK 41.208 0.045729 12724000.0 2504.8 3220.8 2402.5 2519.7 2937.0 2902.8 3208.6 2688.1 1004.3 2123.1 True False 2563.1569665076304 2843.7072386907025 2076.2536959878607 2079.6816956269236 2671.348868569465 2873.600467531521 2966.5727187413213 2616.802855820623 1704.2237488301646 2395.620565745273 1.0699344475322774 1.1870440917700298 0.8666872065117467 0.8681181508307593 1.115096817403725 1.199522373710108 1.2383316294575333 1.0923277639364148 0.7113913501990595 1.0 11.226183707285282 -8.237158317029673 24.10585816856931 0.8556956684684381 1.0795329488434788 0.3032628592888572 0.13577215426781805 565.1157783120958 561040.2378878648 0.09924010778860545 0.03745999755802308 5.792175108931054e-09 8.237158317029673 0.2238372803750407 GPAADPS(ph)SPGTSGVGPAAGAGDSR ddPTM_A459_Selumetinib_30min_R1 1 GPAADPSSPGTSGVGPAAGAGDSR 24 0 A0A0U1RRM4 A0A0U1RRM4 1 GPAADPS(0.88)S(0.113)PGT(0.005)S(0.001)GVGPAAGAGDSR 219.61 2.4e-34 10454000.0 3022.3 3477.9 3156.2 3290.5 2949.5 2456.4 3256.4 2801.3 1508.4 2639.6 True False 3092.7137096279225 3070.7058511681553 2727.605375765611 2715.87594533492 2682.7182457765184 2431.6908462327515 3010.767126257319 2727.0004240952026 2559.6446308228838 2978.418371881316 1.0383745073645956 1.0309853982093677 0.9157898707301891 0.911851730091041 0.900719076642675 0.8164369617075574 1.010861051181191 0.9155867590128698 0.8593972744017443 1.0 11.54033070501744 -5.258622242573072 5.353022461503191 0.9120661752146 1.0364504170841298 0.4300384414762074 0.0543670670219106 0.14258149448384924 14.714220218582232 0.013914814090908218 0.034201870933906565 5.512870076224739e-06 5.258622242573072 0.12438424186952979 GPAADPSS(ph)PGTSGVGPAAGAGDSR ddPTM_A459_Selumetinib_30min_R1 2 GPAADPSSPGTSGVGPAAGAGDSR 24 0 A0A0U1RRM4 A0A0U1RRM4 1 GPAADPS(0.046)S(0.922)PGT(0.01)S(0.021)GVGPAAGAGDSR;GPAADPS(0.156)S(0.844)PGTSGVGPAAGAGDSR 262.98 2.7452999999999987e-62 19969500.0 6175.5 7166.8 7912.5 7657.700000000001 7620.6 5701.7 7146.7 6294.8 3554.0 5080.4 True False 6319.3771345687765 6327.7077242450705 6838.025960251376 6320.426447832003 6931.318075526207 5644.346074729393 6607.618665158816 6127.841455607925 6030.878426110133 5732.51882728665 1.1023735507834174 1.1038267670618604 1.1928484085743494 1.1025565965430286 1.20912260113884 0.9846188464070006 1.1526553796398735 1.0689614182232685 1.0520468589485128 1.0 12.484953472712984 -6.757353882598664 24.999999557333517 1.0622790232385941 1.1406341855351831 0.39943766074448717 0.05469240857521891 122.47308684234493 749438.3815093904 0.01777846061487832 0.017170013026168246 1.7484214159228997e-07 6.757353882598664 0.07835516229658901 GPAADPSS(ph)PGTSGVGPAAGAGDSR ddPTM_A459_Selumetinib_30min_R2 2 GPAADPSSPGTSGVGPAAGAGDSR 24 0 A0A0U1RRM4 A0A0U1RRM4 1 GPAADPS(0.042)S(0.956)PGT(0.003)SGVGPAAGAGDSR;GPAADPS(0.004)S(0.991)PGT(0.004)S(0.001)GVGPAAGAGDSR 361.7 1.3006999999999987e-239 29360000.0 70622.0 65573.0 77249.0 91855.0 83285.0 60901.0 63908.0 66571.0 59281.0 68920.0 True False 66697.11196226544 70602.23824957291 72278.88344235191 79344.19054128694 72821.99372265319 69289.55994576552 66879.8486312997 66764.71058857765 71138.85644953328 66930.10052433478 0.9965189270560766 1.0548652653510209 1.0799159552445674 1.185478430776278 1.0880305445854845 1.0352525904331025 0.9992491884422494 0.9975289154735845 1.0628828567748567 1.0 16.03036756068144 -6.873025129052668 4.108878575767576 1.0150921117472274 1.0851688934596493 0.3083030683664211 0.04689387529415766 0.2927223069541457 8.974792216461271 0.018535911497992177 0.01633530501075796 1.3395991735879623e-07 6.873025129052668 0.07007678171242193 GPAES(ph)PDEGITTTEGEGECEQTPEELEPVEK ddPTM_A459_Selumetinib_30min_R2 2 GPAESPDEGITTTEGEGECEQTPEELEPVEK 31 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 GPAES(0.998)PDEGITT(0.001)T(0.001)EGEGECEQTPEELEPVEK;GPAES(0.93)PDEGIT(0.004)T(0.01)T(0.01)EGEGECEQT(0.047)PEELEPVEK 89.186 5.3178e-07 5843600.0 43644.0 33576.0 38752.0 45973.0 43933.0 33588.0 38691.0 37708.0 31729.0 41312.0 True False 41218.441200774745 36151.17123614389 36258.73850998742 39711.39809215151 38413.74377399677 38214.44211849346 40490.20816476205 37817.72403710453 38075.68658233231 40119.21521853342 1.0273989901411014 0.9010936789073467 0.9037748697845261 0.9898348678018628 0.9574899101279332 0.9525221744826147 1.0092472632928584 0.9426336938822848 0.9490635939643933 1.0 15.292005764876324 -5.781714423509518 24.999934451827144 0.9693444764335293 0.9397895941386958 0.09070934561232347 0.03869107880034663 532.5230803463719 656620.5275497749 0.010782493565691567 0.016014718864481223 1.6530484263422653e-06 5.781714423509518 -0.029554882294833495 GPAFNMAS(ph)PESDFGINLK ddPTM_A459_Selumetinib_30min_R1 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GPAFNMAS(0.943)PES(0.057)DFGINLK 177.12 2.1007e-09 41171000.0 1742.3 2221.5 2322.0 1931.1 2128.9 1653.6 2012.3 1790.7 935.81 1786.8 True False 1782.8922000743557 1961.4057472526679 2006.685153833011 1593.8696362365176 1936.3413708878224 1636.966285348672 1860.5105908879757 1743.2048189866418 1588.0012211418464 2016.153184905869 0.884303937529229 0.9728455962259845 0.9953039128456402 0.7905498690125239 0.9604138144782025 0.8119255508976116 0.922802198174659 0.8646192323268479 0.7876391699949067 1.0 10.977389541906762 -5.741461303956889 24.999964246040044 0.8739004009830156 0.9530205823586814 0.1828909706679419 0.07141100379128856 375.12967032699834 469422.38872815605 0.018173522833216032 0.03142392680676194 1.8135882610763712e-06 5.741461303956889 0.07912018137566579 GPAFNMASPES(ph)DFGINLK ddPTM_A459_Selumetinib_30min_R1 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GPAFNMAS(0.037)PES(0.963)DFGINLK 144.17 0.00028708 37002000.0 3737.0 4311.7 4785.2 4601.8 4305.6 3669.0 4999.1 4362.7 2589.2 3576.9 True False 3824.064829063806 3806.8841595450526 4135.396123222103 3798.182016484497 3916.159240215421 3632.09319118546 4622.013862201499 4246.987023953216 4393.683292314113 4036.0299569564622 0.9474817753700477 0.943224951287476 1.0246197791704628 0.9410688367012706 0.9702998446445044 0.8999173023790914 1.145188195205301 1.052268459165708 1.0886151339737216 1.0 11.978721167379929 -7.257912470618618 24.999088445402705 1.0758736520623355 0.9572295857975345 0.6230536406819902 0.044531071501586375 196.04729772490188 1389609.699529117 0.016795079271784277 0.01247498766387669 5.521887183061135e-08 7.257912470618618 -0.11864406626480106 GPAFNMASPES(ph)DFGINLK ddPTM_A459_Selumetinib_30min_R2 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GPAFNMAS(0.373)PES(0.627)DFGINLK 87.15700000000002 0.006985300000000001 10638000.0 18723.0 14685.0 15467.0 23751.0 16101.0 16450.0 17304.0 16038.0 11959.0 19204.0 True False 17682.450614107445 15811.292280282716 14471.870059196315 20516.072827239706 14078.248435233696 18715.83818176782 18108.67028722551 16084.667924766174 14351.13416237865 18649.530622015776 0.948144538996242 0.8478118082831254 0.7759911148708627 1.1000852108857087 0.7548848665721549 1.0035554546168453 0.9709987159595437 0.8624703887066315 0.7695171773083196 1.0 14.186851700227727 -3.3173978745033517 19.625929226272262 0.9004492400437121 0.9527222615122986 0.0 0.1121084053087718 0.0 0.0 0.024483660434405804 0.0 0.0004815064682084729 3.3173978745033517 0.05227302146858648 GPAGDATVASEKES(ph)VM ddPTM_A459_Selumetinib_30min_R1 2 GPAGDATVASEKESVM 16 1 M0QXM4;Q15758-3;Q15758-2;Q15758 M0QXM4 SLC1A5 Amino acid transporter;Neutral amino acid transporter B(0) 1 GPAGDAT(0.008)VAS(0.292)EKES(0.7)VM;GPAGDATVAS(0.059)EKES(0.941)VM 140.77 0.0018925 13736100.0 4117.8 3225.1 4523.2 3388.5 3711.0 3645.3 3868.5 4123.0 1922.5 2812.5 True False 4213.73672815599 2847.5037926916866 3908.9742841591224 2796.762085022754 3375.3407052302655 3608.63159166758 3576.6959304527813 4013.6446466085476 3262.342086155523 3173.5117710699333 1.3277835508816627 0.8972721697930445 1.231750365570956 0.8812830349388747 1.0635979787439978 1.1371098807838826 1.1270466878548608 1.2647328688670243 1.0279911723962634 1.0 11.63186447848263 -6.758890316777248 23.79614377251532 1.1289013404561974 1.0675203708068877 0.0002524955920488736 0.1427277264731795 139.7718160449794 1304804.019609193 0.04540678335005959 0.04340353769336852 1.742246830900194e-07 6.758890316777248 -0.061380969649309725 GPAGEAGAS(ph)PPVR ddPTM_A459_Selumetinib_30min_R1 2 GPAGEAGASPPVR 13 0 Q13425;Q13425-2;A0A140TA73 Q13425 SNTB2 Beta-2-syntrophin 1 GPAGEAGAS(1)PPVR;GPAGEAGAS(1)PPVR 103.11 0.0087559 100559000.0 6653.8 7963.1 7387.3 7537.6 6756.299999999999 6352.799999999999 7417.099999999999 6274.9 4221.7 6586.3 True False 6808.820593958992 7030.776550055247 6384.1452355342835 6221.29965827579 6145.193857921648 6288.896599880888 6857.6221754585295 6108.4692682522345 7163.9165592316085 7431.715760994816 0.9161842046886299 0.9460502495205899 0.8590405554853588 0.8371283103866988 0.8268876334284139 0.8462240486763518 0.9227508688438539 0.8219460303248397 0.9639653600358687 1.0 12.859479609035366 -8.436363086454904 5.089076201628552 0.999246174420414 0.8725164632448746 0.5441327260486912 0.040843649509462836 0.15967671061127753 6.3853337695493355 0.04202286057523407 0.01093457770197034 3.6613134713588712e-09 8.436363086454904 -0.12672971117553933 GPALTPIRDEEWGGHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 GPALTPIRDEEWGGHSPR 18 1 S4R3V8;Q86X29-6;Q86X29-5;Q86X29-2;Q86X29-3;Q86X29-4;Q86X29 S4R3V8 LSR Lipolysis-stimulated lipoprotein receptor 1 GPALTPIRDEEWGGHS(1)PR;GPALTPIRDEEWGGHS(1)PR 70.134 0.01039 5039000.0 30361.0 13923.2 23455.0 26649.0 19765.9 16136.900000000001 34980.0 27585.0 20985.5 17331.4 True False 28673.657164712728 14991.064669855801 21945.9308358731 23019.36022791085 17282.730932612005 18359.611498806633 36606.63931155503 27665.2677830574 25183.186383861295 16830.997449614897 1.7036219778744484 0.8906818930210703 1.3038995996268323 1.3676765323517737 1.0268393768313144 1.0908213582568578 2.174953648536891 1.6437093443734314 1.496238500377023 1.0 14.038833056690999 GPAPAPQQCS(ph)EPETK ddPTM_A459_Selumetinib_30min_R1 1 GPAPAPQQCSEPETK 15 0 Q3YEC7;Q3YEC7-2;G3V154 Q3YEC7 RABL6 Rab-like protein 6 1 GPAPAPQQCS(0.927)EPET(0.073)K 135.55 0.00040928 16460000.0 5643.8 6433.9 5650.9 5659.6 5779.4 5925.9 5889.7 6040.2 3475.9 5495.7 True False 5775.289559076883 5680.61599696104 4883.538818171816 4671.25710384972 5256.654290435945 5866.2908262866995 5445.435187175324 5879.994274665278 5898.3484303084415 6201.126627651218 0.931329080319776 0.9160619252041737 0.7875244469925523 0.7532916813890378 0.8476934283193298 0.9460040374161263 0.8781364281280409 0.9482138694678495 0.9511736793129382 1.0 12.598314634430302 -7.67025271966773 0.8812734968910432 0.9867347020209231 0.8482525915512785 0.433029149732474 0.056106800079997896 0.6401552835773839 0.9119622795884178 0.05551022528420591 0.024873982157407278 2.1367183530105006e-08 7.67025271966773 -0.13848211046964454 GPAPAPQQCSEPET(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GPAPAPQQCSEPETK 15 0 Q3YEC7;Q3YEC7-2;G3V154 Q3YEC7 RABL6 Rab-like protein 6 1 GPAPAPQQCS(0.398)EPET(0.602)K 127.66 0.0024248 18753000.0 6613.7 6985.6 6163.4 6583.3 6013.3 6470.9 6440.5 6599.2 3531.0 6367.7 True False 6767.786341980011 6167.722704482664 5326.444133132811 5433.650238846182 5469.398076734342 6405.808621107114 5954.687899723701 6424.1677787773715 5991.849105963671 7185.056321650493 0.9419253014881543 0.8584097922653255 0.7413225303582954 0.7562432353485028 0.7612185391301088 0.8915460553600258 0.828760086651045 0.8941012416868103 0.8339320998651923 1.0 12.810783750272659 -9.214759635961311 0.5460040870649102 1.0083431455086171 0.817075452492685 0.39603175468653196 0.06211351448066685 2.7330689614534474 1.2476992055922458 0.12468557932496564 0.03105650826397028 6.098743440827133e-10 9.214759635961311 -0.19126769301593216 GPAPGPPPAGSALGGAPPVPS(ph)RPGASPDPFGPPPQVPSRPNR ddPTM_A459_Selumetinib_30min_R1 1 GPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNR 42 2 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 1 GPAPGPPPAGS(0.017)ALGGAPPVPS(0.884)RPGAS(0.099)PDPFGPPPQVPSRPNR 66.00399999999999 5.4904e-08 52597000.0 1544.5 1988.4 1522.8 1817.1 1667.8 1551.0 1740.5 1918.0 1017.1 1480.7 True False 1580.4838449261558 1755.5972036179196 1316.0121241416498 1499.777596191485 1516.947784474005 1535.3983481953242 1609.2126837154115 1867.1284094579653 1725.9444139551545 1670.7622682393792 0.9459657277223783 1.0507761858112454 0.787671680860043 0.8976606814157498 0.907937540433289 0.9189807415350005 0.9631607765545079 1.1175308689640888 1.033028125404056 1.0 10.706290752452711 -7.57623700208082 5.372505853332677 1.0558307022335651 0.9184995622370058 0.44379310164960495 0.0659177407815983 0.18100556577483046 11.21836394642199 0.03260901404421687 0.01861596622066239 2.6531572925843452e-08 7.57623700208082 -0.13733113999655933 GPAPGPPPAGSALGGAPPVPS(ph)RPGASPDPFGPPPQVPSRPNR ddPTM_A459_Selumetinib_30min_R2 2 GPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNR 42 2 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 1 GPAPGPPPAGS(0.006)ALGGAPPVPS(0.743)RPGAS(0.25)PDPFGPPPQVPS(0.001)RPNR;GPAPGPPPAGS(0.218)ALGGAPPVPS(0.691)RPGAS(0.09)PDPFGPPPQVPS(0.001)RPNR 62.447 4.8035e-06 28912000.0 43110.0 37915.0 46176.0 42727.0 51147.0 35032.0 37654.0 41027.0 32729.0 39972.0 True False 40714.118783003374 40822.95858405987 43205.08643262743 36907.50889181384 44721.456600018486 39857.340011166576 39404.985609985524 41146.38177761453 39275.71452466683 38817.90450027152 1.0488489604769518 1.0516528161321619 1.1130195457182708 0.9507857100208922 1.1520832248867445 1.0267772185097674 1.0151239773829084 1.0599846206877737 1.0117937851176924 1.0 15.24443461896464 -8.205194763160613 0.6673283585530331 0.9998282587566344 1.0584515515116155 0.11736644682316433 0.05108418857710117 1.5698124577702517 1.57801508847652 0.04777289851885079 0.021130631950752786 6.234551788495049e-09 8.205194763160613 0.05862329275498113 GPAPGPPPAGSALGGAPPVPSRPGAS(ph)PDPFGPPPQVPSRPNR ddPTM_A459_Selumetinib_30min_R1 1 GPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNR 42 2 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 1 GPAPGPPPAGS(0.003)ALGGAPPVPS(0.418)RPGAS(0.573)PDPFGPPPQVPS(0.006)RPNR 70.98100000000002 2.3523e-08 48792000.0 2643.6 3080.0 2779.1 2976.4 3042.8 2573.2 3326.7 3015.1 1546.4 2574.2 True False 2705.190736449847 2719.3921681468464 2401.713484503584 2456.6276139476827 2767.579277249972 2547.315944278664 3075.764340658464 2935.1297535749254 2624.127855412693 2904.623644831369 0.9313395011651845 0.936228751351614 0.8268587528636668 0.8457645169690495 0.9528185457605635 0.8769865758035414 1.0589200931871607 1.0105026029096198 0.9034312793267368 1.0 11.504135528873578 -7.243216348469702 24.73486954666342 0.9940887143613968 0.8941663810315953 0.4663256060096511 0.05146416750143167 662.1814058500572 898807.3736889573 0.02045532197100586 0.015811430254716333 5.711940193376766e-08 7.243216348469702 -0.0999223333298015 GPAS(ph)PTRPAAPRPAEAPLLDL ddPTM_A459_Selumetinib_30min_R1 1 GPASPTRPAAPRPAEAPLLDL 21 2 A0A0D9SFE4 A0A0D9SFE4 DNM1 1 GPAS(0.585)PT(0.415)RPAAPRPAEAPLLDL 60.334 0.022959 13922000.0 1356.6 1671.4 1636.6 1995.0 1538.2 1491.2 1624.3 1567.5 893.5 1267.5 True False 1388.2061405159104 1475.7117109872204 1414.358709200304 1646.6107007880764 1399.0700815912674 1476.1998819012695 1501.7777432685675 1525.9248080424193 1516.2042413419822 1430.1959714955176 0.9706405053457817 1.031824827085835 0.9889265089464258 1.1513182344278734 0.9782366259417563 1.032166158570316 1.0500503240113304 1.0669340694945466 1.0601374018390837 1.0 10.481997129381572 -4.496734838773679 1.2838620995878054 1.0456245988422541 0.8943097514503296 0.17012159565676754 0.046539365100257905 4.509627215873961 4.053191034801264 0.013269978683145377 1.0701290582061138 3.1861422471637174e-05 4.496734838773679 -0.15131484739192447 GPAS(ph)TPTYSPAPTQPAPR ddPTM_A459_Selumetinib_30min_R1 1 GPASTPTYSPAPTQPAPR 18 0 Q6P1N0;Q6P1N0-2;K7EJY5 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 GPAS(0.483)T(0.483)PT(0.033)YSPAPTQPAPR 309.35 2.0574999999999997e-111 7907900.0 667.5 935.27 968.81 951.67 877.47 782.56 737.81 719.03 345.24 472.81 True False 683.0514512710972 825.7681536047729 837.2509232924034 785.4786995583904 798.1029934299113 774.6881569076293 682.1563976857612 699.958988661398 585.8470646680533 533.499769059405 1.2803219249285929 1.5478322606599364 1.5693557370578277 1.4723131013594264 1.4959762678754651 1.4520871457422655 1.2786442230114694 1.3120136675887817 1.0981205590790415 1.0 9.059343836312854 -8.013762493795255 0.8676702244551818 0.9994230729778866 1.48737469026844 0.8000350981485207 0.08138995156914663 0.23839560982006752 0.34822847917156036 0.07536372457480195 0.02966614015246333 9.688075311780876e-09 8.013762493795255 0.48795161729055336 GPAS(ph)TPTYSPAPTQPAPR ddPTM_A459_Selumetinib_30min_R2 1 GPASTPTYSPAPTQPAPR 18 0 Q6P1N0;Q6P1N0-2;K7EJY5 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 GPAS(0.825)T(0.129)PT(0.04)YS(0.006)PAPTQPAPR 160.72 1.2186e-05 8098100.0 25817.0 26115.0 29325.0 28639.0 29991.0 18273.0 24244.0 22905.0 21272.0 27067.0 True False 24382.194493639472 28117.936527040078 27438.26142664586 24738.318794969382 26223.262457058197 20789.93988422148 25371.394038574617 22971.64975787311 25526.99438934014 26285.50538148828 0.9275908581468923 1.069712608487349 1.043855198080742 0.9411391729371689 0.9976320438383537 0.7909279118849628 0.9652237486155609 0.8739284036764622 0.9711433742231821 1.0 14.681979852878781 -6.142041985827965 1.9708045601763715 0.9182096647417939 1.0157257912297852 0.19326177028016023 0.06934115070211196 0.4442026653655014 3.402189709862339 0.022258729463543427 0.031757027086772804 7.210377688080751e-07 6.142041985827965 0.09751612648799135 GPASPT(ph)RPAAPRPAEAPLLDL ddPTM_A459_Selumetinib_30min_R1 2 GPASPTRPAAPRPAEAPLLDL 21 2 A0A0D9SFE4 A0A0D9SFE4 DNM1 1 GPAS(0.1)PT(0.9)RPAAPRPAEAPLLDL;GPAS(0.01)PT(0.99)RPAAPRPAEAPLLDL 68.525 0.024913 39696000.0 3491.9 4141.7 4869.200000000001 5054.0 4838.9 4282.1 4293.9 4307.0 2527.7 3280.9 True False 3573.254475945385 3656.787838575905 4207.989384601076 4171.413775329795 4401.222349377183 4239.025961835718 3970.007665961276 4192.764368892312 4289.322284096395 3702.0354736723043 0.9652134619879337 0.9877776332997925 1.1366691147415942 1.1267892501288979 1.1888655256485985 1.145052766777174 1.0723850957654795 1.132556508091269 1.1586388932793021 1.0 11.854103004140136 -5.230647112849565 5.500127324936108 1.1268971355530533 0.9733729570812869 0.5708971115607571 0.049573300856359956 0.11982954376124108 10.812179388264344 0.012272239704782308 0.03230015577324139 5.8796691257983255e-06 5.230647112849565 -0.15352417847176636 GPASQFYITPSTSLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 GPASQFYITPSTSLSPR 17 0 H0YIQ2;P49750-3;P49750-1;P49750 H0YIQ2 YLPM1 YLP motif-containing protein 1 1 GPASQFYITPS(0.011)T(0.001)S(0.005)LS(0.983)PR;GPASQFYITPSTSLS(1)PR 201.22 4.6017e-08 134213000.0 7218.4 7878.5 8694.0 10056.900000000001 8341.2 7100.700000000001 8229.6 7251.4 3982.9 6687.6 True False 7386.574675438629 6956.081557384717 7513.402552723604 8300.65120639379 7586.739932758468 7029.273404919755 7608.834646311027 7059.069316133202 6758.690400493539 7546.018602740377 0.9788704566347286 0.9218214165094396 0.9956777140723018 1.1000040741192136 1.0053963993679134 0.9315208158070319 1.0083243955359238 0.9354693763370346 0.8956630981586878 1.0 12.881499941402769 -7.771794046911012 24.551261659972283 0.9366746445088246 0.9915102389819155 0.14973084205018994 0.05154837572757684 317.9225594767145 753789.7064787623 0.029563006718647367 0.014455631082968113 1.691242770280826e-08 7.771794046911012 0.05483559447309083 GPASQFYITPSTSLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 GPASQFYITPSTSLSPR 17 0 H0YIQ2;P49750-3;P49750-1;P49750 H0YIQ2 YLPM1 YLP motif-containing protein 1 1 GPASQFYITPSTSLS(1)PR;GPASQFYITPSTSLS(1)PR;GPASQFYITPST(0.001)S(0.004)LS(0.995)PR;GPASQFYITPSTSLS(1)PR 245.1 2.7385e-23 87201400.0 306054.0 253049.0 300195.0 348401.0 325249.0 255719.0 257471.0 253792.0 230139.0 271639.0 True False 289044.7439112344 272457.0446192206 280880.7805276033 300948.1827747527 284388.31285704783 290941.9710640416 269443.91166910785 254530.49270247243 276173.2306209259 263796.076267119 1.0957128248509227 1.0328320590459865 1.064764815694925 1.1408364636554096 1.078061193636092 1.1029048467325753 1.0214098537093854 0.9648759614026091 1.0469194027786595 1.0 18.009063580375518 -7.378906990027904 4.807087799167148 1.0026340432813596 1.0844390249520344 0.5879319690392186 0.031954435538559076 0.1675194183205232 5.9023600341172 0.014157478260009257 0.009335323111919359 4.179198601910018e-08 7.378906990027904 0.08180498167067474 GPAST(ph)PTYSPAPTQPAPR ddPTM_A459_Selumetinib_30min_R1 1 GPASTPTYSPAPTQPAPR 18 0 Q6P1N0;Q6P1N0-2;K7EJY5 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 GPAS(0.001)T(0.992)PT(0.006)YS(0.001)PAPTQPAPR 217.79 7.319600000000002e-14 7963900.0 1501.3 1558.1 2286.7 2242.8 2204.2 1764.6 1750.5 1781.7 941.37 1353.3 True False 1536.2773689787236 1375.676927658961 1976.17869994399 1851.1370825701747 2004.8304991831176 1746.8497261286068 1618.4583756643653 1734.4435282227619 1597.4361350555134 1527.0092372582917 1.0060694667028163 0.9008962710199159 1.294149800620834 1.2122631857118604 1.312913144378054 1.1439680150625895 1.0598877440782666 1.1358435076246909 1.0461208066584269 1.0 10.576493074044016 -10.595794009436194 12.493638963022953 1.0000137848772424 1.1293016910020168 0.08374218861339633 0.12129350510521585 0.0 0.0 0.1268281815205616 0.03076035227731091 2.536331354600558e-11 10.595794009436194 0.12928790612477448 GPASTPT(ph)YSPAPTQPAPR ddPTM_A459_Selumetinib_30min_R2 1 GPASTPTYSPAPTQPAPR 18 0 Q6P1N0;Q6P1N0-2;K7EJY5 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 GPAS(0.005)T(0.001)PT(0.497)YS(0.497)PAPTQPAPR 277.34 1.8794999999999993e-66 7695400.0 10159.0 10656.0 11767.0 12166.0 12347.0 8882.3 8789.3 8327.6 7286.2 12356.0 True False 9594.403449699168 11473.280935559593 11009.9240309409 10508.969812479398 10795.859476419511 10105.756199508589 9198.019865667542 8351.831937291607 8743.64359343786 11999.250175256553 0.7995835831045195 0.9561664910711211 0.91755100278218 0.8758022092205198 0.8997111751767178 0.8421989750949184 0.7665495536241607 0.6960294864518931 0.7286824981337565 1.0 13.55065663519677 -7.042312601911269 3.0285433569710873 0.772969822773679 0.8939399627611263 0.18041602709710458 0.08561344875736969 0.32854262338310314 6.0287193763936155 0.033198307267405955 0.026127796889456316 9.071673228834318e-08 7.042312601911269 0.12097013998744732 GPAVGIDLGTTYS(ph)CVGVFQHGK ddPTM_A459_Selumetinib_30min_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 GPAVGIDLGTT(0.029)Y(0.001)S(0.97)CVGVFQHGK 105.72 0.00013418 0.0 1306.6 1733.9 1676.5 1957.5 1568.9 1291.5 1350.1 1423.5 790.36 1396.2 True False 1337.0412377989749 1530.8941819317597 1448.8405083553155 1615.6593718258937 1426.9932720117922 1278.5086825881763 1248.260870028254 1385.7441558203413 1341.183194389534 1575.4158701396768 0.8486909794049697 0.9717397234268246 0.9196559053495258 1.025544684707695 0.9057883058428722 0.8115372625228304 0.7923373717935079 0.879605304279105 0.8513200989086294 1.0 10.62151699873001 -6.527910428041025 22.015444371315713 0.8552037166432676 0.9449763971798042 0.20663176649535941 0.06674949719705134 39.928592668262034 174693.67973172994 0.02114019136813825 0.021248877767770954 2.9654429403374833e-07 6.527910428041025 0.08977268053653664 GPCAPAASS(ph)PTQK ddPTM_A459_Selumetinib_30min_R2 4 GPCAPAASSPTQK 13 0 E9PIR9;E7ET48;Q8N1P7 E9PIR9 AIM1L Absent in melanoma 1-like protein 1 GPCAPAAS(0.045)S(0.946)PT(0.009)QK;GPCAPAAS(0.201)S(0.485)PT(0.314)QK;GPCAPAAS(0.044)S(0.955)PT(0.001)QK;GPCAPAAS(0.131)S(0.435)PT(0.435)QK 184.96 9.9313e-15 6854600.0 125526.0 129489.0 135994.0 144363.0 157882.0 125348.0 139569.0 160063.0 127919.0 157846.0 True False 118549.76744039159 139420.38992724085 127244.294099072 124700.51035993459 138047.45167701165 142613.54920414794 146059.2350507269 160528.75683014395 153506.3743554911 153288.57584683955 0.7733764032020382 0.9095289010091966 0.8300963943080137 0.8135016564086999 0.9005723415092832 0.9303599333236828 0.9528383589176537 1.0472323585975416 1.001420839794801 1.0 17.22589065556098 -6.9876384783460015 1.1193852377226898 1.017677305741322 0.8359063599431589 0.802721802894846 0.03759508354247877 0.20830900771378577 0.5377446064629774 0.022025066615565206 0.015996825314046604 1.0288724105065306e-07 6.9876384783460015 -0.1817709457981631 GPDEAMEDGEEGS(ph)DDEAEWVVTK ddPTM_A459_Selumetinib_30min_R1 4 GPDEAMEDGEEGSDDEAEWVVTK 23 0 Q9NZN4;Q9NZN4-2 Q9NZN4 EHD2 EH domain-containing protein 2 1 GPDEAMEDGEEGS(0.997)DDEAEWVVT(0.003)K;GPDEAMEDGEEGS(0.99)DDEAEWVVT(0.01)K;GPDEAMEDGEEGS(1)DDEAEWVVTK;GPDEAMEDGEEGS(1)DDEAEWVVTK 140.09 1.9503e-06 43369900.0 18964.0 22938.8 18295.4 17982.3 20515.2 19606.300000000003 22143.9 21664.5 11661.400000000001 17920.2 True False 19405.82430247953 20253.1146320412 15810.98516943862 14842.028874577149 18659.603782252747 19409.078423096074 20473.567794843835 21089.887083786285 19788.54408504241 20220.432227529753 0.9597136245217771 1.0016163059297492 0.7819311175708821 0.7340114547289447 0.9228093431577606 0.9598745568193624 1.0125188010061152 1.042998826457962 0.9786410034351622 1.0 14.303526215853136 -6.80410173876123 2.5945567811332535 1.009211845330066 0.8699915535050172 0.4063161681564228 0.07440504992387532 0.31039272440790394 4.2741424168254705 0.03189533950128651 0.028801482700428038 1.569994970845311e-07 6.80410173876123 -0.1392202918250488 GPDEAMEDGEEGS(ph)DDEAEWVVTK ddPTM_A459_Selumetinib_30min_R2 4 GPDEAMEDGEEGSDDEAEWVVTK 23 0 Q9NZN4;Q9NZN4-2 Q9NZN4 EHD2 EH domain-containing protein 2 1 GPDEAMEDGEEGS(1)DDEAEWVVTK;GPDEAMEDGEEGS(1)DDEAEWVVTK;GPDEAMEDGEEGS(1)DDEAEWVVTK;GPDEAMEDGEEGS(1)DDEAEWVVTK 118.85 7.0660000000000015e-06 14801800.0 256052.0 235722.0 292592.0 308795.0 344811.0 268137.0 296959.0 306000.0 266339.0 295664.0 True False 241821.65489736866 253801.11943430686 273766.94927008206 266736.5882989129 301492.7595305488 305070.4378446614 310768.18191309547 306890.40933897323 319614.24213343597 287127.4120926725 0.8422102687266897 0.8839320411260165 0.9534685221267615 0.9289833609227869 1.0500312642849992 1.062491510724158 1.082335467896018 1.0688300608509023 1.113144299960737 1.0 18.131331545846784 -5.88555992995478 0.8983947986778956 1.0770771125576515 0.8475375827275239 0.8479971495940792 0.034051847873302864 0.2394624153422677 0.37483425832760203 0.01444293640558892 0.038713321612679305 1.3014877059261646e-06 5.88555992995478 -0.2295395298301276 GPDGPWGVGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GPDGPWGVGTPR 12 0 Q8TER5;Q8TER5-2;Q8TER5-4;Q8TER5-3 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 GPDGPWGVGT(1)PR 120.55 0.0093642 2305100.0 25478.0 22514.0 21457.0 26197.0 20081.0 20065.0 22468.0 23653.0 14805.0 22187.0 True False 24062.03475651494 24240.75140608003 20076.479980615182 22628.923407654354 17558.24525358225 22828.771618065126 23512.806519497397 23721.826314035054 17766.413686262735 21546.40366125099 1.1167541059201473 1.1250486061242113 0.9317786994179768 1.0502413193135411 0.8149037551523719 1.0595165660578587 1.0912636228839794 1.1009645362161453 0.8245651555397997 1.0 14.395159466819392 -5.245043526750594 23.685567689532547 0.9905925288657303 1.1209014208208172 0.2420748472055806 0.09624902925301997 618.1938340078464 893038.8594752889 0.024567419853578833 0.06449529668166226 5.687959209578562e-06 5.245043526750594 0.13030889195508688 GPEEEEIGSPEPMAAPASASQKLS(ph)PLQK ddPTM_A459_Selumetinib_30min_R2 1 GPEEEEIGSPEPMAAPASASQKLSPLQK 28 1 H3BRB3;Q14807-2;Q14807 H3BRB3 KIF22 Kinesin-like protein;Kinesin-like protein KIF22 1 GPEEEEIGSPEPMAAPAS(0.303)AS(0.303)QKLS(0.394)PLQK 61.612 0.0016966999999999998 2798100.0 8970.3 10939.0 14372.0 12886.0 11260.0 9452.3 7112.8 8317.1 4027.7 11971.0 True False 8471.766636956041 11777.986125571173 13447.321167050455 11130.904570410123 9845.4181343228 10754.268525563757 7443.559293745821 8341.301384029974 4833.352543340789 11625.366125606686 0.728731168156128 1.0131281886794359 1.1567223794724735 0.9574670122339257 0.8468910164159671 0.925069233034803 0.6402860102057533 0.7175087041479884 0.4157591675925436 1.0 13.504988532267273 -7.217792634537496 4.960623092996244 0.6691711731293004 0.9504219463821756 0.331038869927878 0.16845965249800923 0.21756083618359415 12.91456555430574 0.06606578279965439 0.04950948280874405 6.056299798853905e-08 7.217792634537496 0.2812507732528752 GPEENYSRPEAPNEFYDGDHDNDKES(ph)DVEI ddPTM_A459_Selumetinib_30min_R2 1 GPEENYSRPEAPNEFYDGDHDNDKESDVEI 30 2 O15379;O15379-2 O15379 HDAC3 Histone deacetylase 3 1 GPEENYSRPEAPNEFY(0.004)DGDHDNDKES(0.996)DVEI 45.489 0.014909 4254100.0 12997.0 11884.0 13867.0 11420.0 10487.0 10321.0 19253.0 17754.0 12594.0 9150.3 True False 12274.67877111331 12795.46458691726 12974.812317248015 9864.576299401178 9169.52930503048 11742.624065290314 20148.302649095745 17805.661200667077 15113.151905761079 8886.107063665433 1.3813336574914192 1.4399404030632121 1.4601233390829786 1.1101122492364093 1.0318949838590104 1.3214587649191114 2.26739364096574 2.003763973705986 1.7007618518977252 1.0 13.117335808329234 -7.122955596525467 9.276365519577935 1.8259190803880692 1.2819181867809217 0.2999961566078092 0.3291015273401158 0.3639201192387489 25.94904552327889 0.12361289391381235 0.09574532754586393 7.534325928375468e-08 7.122955596525467 -0.5440008936071474 GPESESEDHR ddPTM_A459_Selumetinib_30min_R2 1 GPESESEDHR 10 0 P78527-2;P78527 P78527-2 PRKDC DNA-dependent protein kinase catalytic subunit 0 115.57 0.0092798 2545300.0 10772.0 9355.3 10040.0 14664.0 14840.0 14673.0 18877.0 38848.0 17660.0 32362.0 False True 10173.3353637326 10072.821427969291 9394.03733072547 12666.737903189049 12975.666528716736 16694.072561767727 19754.81790406588 38961.04124836737 21192.49346162782 31427.62497342609 0.3237067825626262 0.3205085155650946 0.2989101893212956 0.4030447071294609 0.4128745503259768 0.531191032598981 0.6285813172573411 1.239706827395046 0.6743269171484425 1.0 14.93974562946126 -7.332528999454724 1.7464486228360008 0.9670855412322644 0.35230033162515445 0.7626956384683985 0.14585096706246112 0.16367581505279297 0.9717367324923712 0.07737716872987452 0.04499484022700585 4.650193240633951e-08 7.332528999454724 -0.61478520960711 down GPGAPAAS(ph)SPTQK ddPTM_A459_Selumetinib_30min_R1 2 GPGAPAASSPTQK 13 0 E9PIR9;E7ET48;Q8N1P7 E9PIR9 AIM1L Absent in melanoma 1-like protein 1 GPGAPAAS(0.5)S(0.5)PT(0.001)QK;GPGAPAAS(0.76)S(0.234)PT(0.006)QK 174.21 0.00012947 20125700.0 12002.8 14660.7 10772.8 12668.7 12769.0 11478.3 13065.3 11974.4 7291.6 11263.9 True False 12282.441886616818 12944.218428425478 9309.912930754634 10456.349365951824 11614.046204550054 11362.838723462533 12079.773902066625 11656.800013667083 12373.31264260682 12709.73128467721 0.9663809258834977 1.018449417890602 0.7325027352843109 0.8227042044986387 0.9137916407840889 0.8940266689321368 0.9504350352890578 0.9171555049098847 0.9735306251143189 1.0 13.633645908054259 -7.997977757802838 0.8846400621679447 0.9962228121561673 0.8871860655202426 0.195246764646128 0.07362953193714017 1.0356585960352949 1.5564917000614986 0.07417119361652622 0.029040768834702045 1.0046672425431865e-08 7.997977757802838 -0.10903674663592466 GPGAPAAS(ph)SPTQK ddPTM_A459_Selumetinib_30min_R2 2 GPGAPAASSPTQK 13 0 E9PIR9;E7ET48;Q8N1P7 E9PIR9 AIM1L Absent in melanoma 1-like protein 1 GPGAPAAS(0.737)S(0.224)PT(0.039)QK;GPGAPAAS(0.486)S(0.486)PT(0.027)QK 125.03 0.0021693000000000003 12856900.0 63921.0 60136.0 69826.0 80629.0 86297.0 65066.0 80439.0 87886.0 62480.0 78397.0 True False 60368.526716037064 64748.23783228341 65333.47118080046 69647.1911072169 75455.59935503155 74028.2508896598 84179.57288685458 88141.73370968948 74977.74583706145 76133.47491013184 0.7929301373317877 0.8504568838965042 0.8581438225159204 0.914803786237639 0.9910962220508066 0.9723482472991407 1.105684102639744 1.1577263984565556 0.9848196988980915 1.0 16.216243307235437 -6.21515739948546 0.9180787330821834 1.069963686588787 0.8122520227545733 0.762376979394322 0.05248041350210666 0.2776252305751562 0.495530317347326 0.025647552108962163 0.04375109926242085 6.093160254253367e-07 6.21515739948546 -0.2577116638342136 GPGAPGLAHLQESQAGS(ph)DTDVEEGK ddPTM_A459_Selumetinib_30min_R2 2 GPGAPGLAHLQESQAGSDTDVEEGK 25 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 GPGAPGLAHLQES(0.001)QAGS(0.972)DT(0.027)DVEEGK;GPGAPGLAHLQESQAGS(0.782)DT(0.218)DVEEGK 161.0 2.5589000000000003e-13 12993000.0 46460.0 42452.0 44217.0 42872.0 45381.0 38640.0 51762.0 54382.0 43658.0 37488.0 True False 43877.939194115876 45707.93189530557 41372.126359829526 37032.75964167491 39679.83306871254 43962.309261003546 54169.035564457205 54540.24261657528 52390.81990644095 36405.62403447863 1.205251670801205 1.2555184290212142 1.136421293606924 1.0172263386174163 1.0899369018131104 1.207569171712816 1.487930422869703 1.498126843394359 1.4390858911475668 1.0 15.151873718432268 -7.099069805319607 4.9958838628759885 1.3961577228832451 1.1406987042184071 0.3129066018568252 0.14601866367059552 0.2308792443641374 9.070008275629721 0.055739160439259146 0.0431465216181738 7.960313918684171e-08 7.099069805319607 -0.255459018664838 GPGAPGLAHLQESQAGS(ph)DTDVEEGKAPQAVPLEK ddPTM_A459_Selumetinib_30min_R1 1 GPGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEK 34 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 GPGAPGLAHLQES(0.011)QAGS(0.893)DT(0.096)DVEEGKAPQAVPLEK 89.583 4.7293e-09 59074000.0 6040.3 8989.7 10879.0 12117.0 8817.4 8911.7 8435.6 6848.0 3567.8 6815.2 True False 6181.027237622187 7937.181744801855 9401.691554069483 10000.993414260201 8019.867726838407 8822.0563891762 7799.295900459476 6666.3687945610745 6054.296018198012 7689.997305669621 0.8037749549099437 1.032143631435344 1.2225871063879148 1.3005197553043026 1.0428960385884118 1.1472118959875244 1.0142130862268668 0.8668883134258248 0.7872949466099745 1.0 12.908767377374838 -7.609612436537632 3.351708487180011 0.8697441152812961 1.1014725604520732 0.3208274784533155 0.13322679397834072 0.28419258819990795 6.33911066718324 0.0742960234313388 0.03982935089257991 2.4569004703702146e-08 7.609612436537632 0.23172844517077706 GPGAPGLAHLQESQAGS(ph)DTDVEEGKAPQAVPLEK ddPTM_A459_Selumetinib_30min_R2 1 GPGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEK 34 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 GPGAPGLAHLQES(0.004)QAGS(0.655)DT(0.341)DVEEGKAPQAVPLEK 75.416 3.8355e-06 18377000.0 81176.0 91064.0 89166.0 87680.0 86182.0 60492.0 69358.0 75435.0 58645.0 84361.0 True False 76664.56289327488 98048.31598308907 83429.15663660056 75737.8327435635 75355.04668314462 68824.22390829779 72583.28443026966 75654.50336106343 70375.63867820842 81925.27873379871 0.9357864151110481 1.196801738101853 1.0183567016926294 0.9244745201253426 0.9198021398010392 0.8400853188663487 0.8859693314699097 0.9234573812911759 0.8590222671915618 1.0 16.32202105579701 -5.709413615329949 3.20574416243462 0.8991365094407856 1.0742357081749638 0.45974958249940423 0.07164455814476678 0.18133693039445797 3.776138103844131 0.019188726294806942 0.03457961381736545 1.9524790592307355e-06 5.709413615329949 0.17509919873417823 GPGAPGLAHLQESQAGSDT(ph)DVEEGKAPQAVPLEK ddPTM_A459_Selumetinib_30min_R2 1 GPGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEK 34 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 GPGAPGLAHLQES(0.019)QAGS(0.162)DT(0.819)DVEEGKAPQAVPLEK 106.43 3.3045e-14 13620000.0 105440.0 97552.0 118340.0 98626.0 109410.0 75062.0 79303.0 96533.0 68885.0 96788.0 True False 99580.06690976273 105033.92472088143 110726.13323884978 85192.9686606604 95664.93766218999 85401.10915500637 82990.74663591338 96813.8950481016 82663.92480771396 93993.47895457537 1.0594359099942157 1.1174596992163852 1.1780193101732181 0.9063710547604261 1.0177827092496745 0.9085854689587405 0.8829415355082311 1.0300065081630745 0.8794644663345561 1.0 16.52027304903934 -5.765445942784064 24.99999827310052 0.9464488002367606 1.1182204556381619 0.649088035792508 0.05790528511670168 58.598976483519166 365647.088165255 0.01565081139812576 0.024212181793621022 1.7161453077327016e-06 5.765445942784064 0.17177165540140127 GPGDLMGPQGLS(ph)PEEMAR ddPTM_A459_Selumetinib_30min_R1 2 GPGDLMGPQGLSPEEMAR 18 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 GPGDLMGPQGLS(1)PEEMAR;GPGDLMGPQGLS(1)PEEMAR 166.21 1.4982e-07 42803000.0 1965.3600000000001 2404.6 2295.69 2060.66 1957.52 2042.1399999999999 2417.6 2022.8 1158.3600000000001 1823.6399999999999 True False 2011.1490640751513 2123.068314131789 1983.9479073225273 1700.8044143789245 1780.4626616282249 2021.5979257147644 2235.238485579073 1969.1487730195893 1965.6523167329578 2057.721957757857 0.9773667703223361 1.0317566501769437 0.9641477070518721 0.8265472446200465 0.865259106030175 0.9824446486042971 1.086268471380187 0.956955708032207 0.9552565201154676 1.0 11.006832341110048 -6.983494878244183 24.933763972006076 1.0015079325162735 0.9332693765871293 0.20345611233804273 0.0631850627152247 425.846541236718 643310.6453429385 0.02513544299296891 0.02216126761463338 1.0387358524516823e-07 6.983494878244183 -0.06823855592914418 GPGDLMGPQGLS(ph)PEEMAR ddPTM_A459_Selumetinib_30min_R2 4 GPGDLMGPQGLSPEEMAR 18 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 GPGDLMGPQGLS(1)PEEMAR;GPGDLMGPQGLS(1)PEEMAR;GPGDLMGPQGLS(1)PEEMAR;GPGDLMGPQGLS(1)PEEMAR 161.14 1.1078e-05 25704800.0 59841.0 56228.0 69776.0 75662.0 76357.0 57814.0 61496.0 67358.0 56709.0 72031.0 True False 56515.27678250302 60540.50679848396 65286.688126364534 65356.70507576986 66764.351019759 65777.35371676132 64355.68585201226 67554.0006282828 68052.38458184886 69951.27787098609 0.8079234361770543 0.8654667740329378 0.9333165899667388 0.9343175287849612 0.9544407629392436 0.9403309806302196 0.9200072938010654 0.9657293288176281 0.9728540586114891 1.0 16.094062792354705 -3.3000494856117326 0.5864877060711071 0.9601767613520703 1.825932024334593e-14 0.8634668025493168 0.019521110615715487 6.5199714643226585 0.43322021735276756 0.009433764110442692 6.233526979857717 0.0005011301291856293 3.3000494856117326 -0.9601767613520521 GPGEPDS(ph)PTPLHPPTPPILSTDR ddPTM_A459_Selumetinib_30min_R2 4 GPGEPDSPTPLHPPTPPILSTDR 23 0 Q03164-2;Q03164;Q03164-3 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 GPGEPDS(0.93)PT(0.07)PLHPPTPPILSTDR;GPGEPDS(0.974)PT(0.026)PLHPPT(0.001)PPILSTDR;GPGEPDS(0.794)PT(0.206)PLHPPTPPILSTDR;GPGEPDS(0.607)PT(0.392)PLHPPT(0.001)PPILSTDR 62.032 0.0054332 21010800.0 36909.6 41775.7 47409.5 43268.5 44616.799999999996 30557.699999999997 26088.800000000003 34336.7 28392.9 41620.7 True False 34858.31219283555 44979.761859952814 44359.22438556067 37375.255657674265 39011.63870474723 34766.74579981802 27301.98089397648 34436.61411225331 34072.27336391008 40419.0022474345 0.8624238663646897 1.1128370162281231 1.0974843988974583 0.9246951577100488 0.9651806461210556 0.8601584370387261 0.6754738953436044 0.8519907023295976 0.8429766067783806 1.0 15.302746088440657 -6.568074136082479 1.8629562245873923 0.8247162658157818 1.0183354540849043 0.33773732560582015 0.10111793725736758 0.3416548419004352 2.4101402614976037 0.03866082169898728 0.04068511471099613 2.7034968252686656e-07 6.568074136082479 0.1936191882691225 GPGGS(ph)PGGLQK ddPTM_A459_Selumetinib_30min_R1 4 GPGGSPGGLQK 11 0 Q96A00-2;Q96A00;K7EJB8;K7EMN0 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 GPGGS(1)PGGLQK;GPGGS(1)PGGLQK;GPGGS(1)PGGLQK;GPGGS(1)PGGLQK 137.4 0.0013365 1542090000.0 35013.4 39670.5 35393.3 38656.0 34740.2 29591.6 34221.0 30511.8 16575.3 28538.7 True False 35829.14409578342 35025.85941768487 30587.084261480588 31905.455262989395 31597.955043880465 29293.93537102307 31639.682418514818 29702.52794770571 28127.073487986312 32201.920135478584 1.1126399899460817 1.0876947483356747 0.9498528079318213 0.9907935653761666 0.9812444385596529 0.9096952991554181 0.9825402424886981 0.922383752979402 0.87345951327285 1.0 14.974859095446526 -4.63852744909164 0.7323589264410914 0.9378559055901583 1.2782029260097194 0.6763108627032415 0.04032133813479127 1.9350845448954115 0.6834475731551458 0.016223120487086292 0.5706446367407787 2.2986484211984663e-05 4.63852744909164 0.3403470204195611 GPGGS(ph)PGGLQK ddPTM_A459_Selumetinib_30min_R2 4 GPGGSPGGLQK 11 0 Q96A00-2;Q96A00;K7EJB8;K7EMN0 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 GPGGS(1)PGGLQK;GPGGS(1)PGGLQK;GPGGS(1)PGGLQK;GPGGS(1)PGGLQK 138.42 0.0012521 1971489000.0 1345952.0 1125044.0 1346450.0 1283030.0 1354540.0 948302.0 1024205.0 1018277.0 785975.0 912799.0 True False 1271149.3761127552 1211331.2572133748 1259820.872903913 1108279.100649796 1184370.5754587578 1078921.9926715356 1071832.561923707 1021240.0174851685 943191.9619763836 886444.1211333775 1.4339870340473424 1.3665060530432618 1.4212073190729142 1.2502526377328642 1.3360916353582013 1.217134805171997 1.2091371992554905 1.1520636136426123 1.064017392061273 1.0 19.757670165115634 -7.183331061554339 0.36487893922280784 0.9799753986345616 1.4611922824172114 0.9188562208705024 0.03960784981567074 0.35466504037972896 0.11359537209851339 0.04475541193554495 0.06135812162191466 6.556452790661528e-08 7.183331061554339 0.4812168837826498 GPGGS(ph)QGSQGPSPQGAR ddPTM_A459_Selumetinib_30min_R1 1 GPGGSQGSQGPSPQGAR 17 0 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 1 GPGGS(0.992)QGS(0.008)QGPSPQGAR 148.33 0.0003488 1022400.0 0.0 139.34 58.932 129.68 131.99 144.77 73.05199999999998 68.59100000000001 0.0 71.434 True False 0.0 123.02600802259144 50.9293580903045 107.03382239508659 120.05152780472719 143.31374524064296 67.54162882549734 66.77174386503198 0.0 80.60324972608345 0.0 1.5263157309497395 0.6318524161665855 1.3279095167852784 1.489412997772448 1.778014481148968 0.837951683772381 0.8284001462961418 0.0 1.0 6.332766100752167 -4.745379816219159 24.879972104440867 1.0672847243799117 3.1468685882067615e-06 0.2899655192502909 0.49039259416746883 1210.3196993415438 1874956.510023435 0.1270408551184154 3.238441041659403 1.7972983838206104e-05 4.745379816219159 -1.0672815775113236 GPGGS(ph)QGSQGPSPQGAR ddPTM_A459_Selumetinib_30min_R2 2 GPGGSQGSQGPSPQGAR 17 0 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 1 GPGGS(0.989)QGS(0.009)QGPS(0.002)PQGAR;GPGGS(0.991)QGS(0.008)QGPS(0.001)PQGAR 174.68 5.189899999999999e-09 0.0 1383.47 600.7 969.97 578.62 0.0 0.0 651.49 0.0 1515.22 481.45 True False 1306.5822758692095 646.7717584450685 907.5631862234848 499.81095782482544 0.0 0.0 681.7855759029444 0.0 1818.3063387841282 467.5492875426733 2.794533775757187 1.38332316116734 1.9411069814551931 1.0690016456911136 0.0 0.0 1.4582111321059765 0.0 3.889015312889705 1.0 8.868974647064476 -8.251521490995934 24.994206426997692 2.4445078066946437 1.0596724731008762 0.204065252826946 1.0766737929071502 955.6430746398156 2408344.2928691343 0.7464682532495396 0.274594964063701 5.603746866225065e-09 8.251521490995934 -1.3848353335937675 GPGGSQGS(ph)QGPSPQGAR ddPTM_A459_Selumetinib_30min_R2 1 GPGGSQGSQGPSPQGAR 17 0 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 1 GPGGS(0.003)QGS(0.844)QGPS(0.153)PQGAR 83.948 0.012712 699020.0 549.56 0.0 1122.0 732.24 1239.3 459.35 1102.4 973.8 2441.1 1949.2 True False 519.0176552629861 0.0 1049.8117415412337 632.5076488155441 1083.6080545174286 522.6212929358688 1153.6637843641593 976.633596778731 2929.3882100328224 1892.9215313701905 0.27418867959481413 0.0 0.5545986582873976 0.33414361785916386 0.5724527068658041 0.2760924234178739 0.6094620221943803 0.5159398213785413 1.547548676205498 1.0 10.886398891874085 -8.151039391973494 4.91804887082144 1.2649117723765275 0.3817495934042733 0.7375697427070877 0.2111942791329574 0.10734728101234785 3.8333338327629143 0.15206207231479826 0.05417601444069502 7.06253491785213e-09 8.151039391973494 -0.8831621789722542 down GPGGSQGSQGPS(ph)PQGAR ddPTM_A459_Selumetinib_30min_R1 4 GPGGSQGSQGPSPQGAR 17 0 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 1 GPGGSQGSQGPS(1)PQGAR;GPGGSQGSQGPS(1)PQGAR;GPGGSQGSQGPS(1)PQGAR;GPGGSQGSQGPS(1)PQGAR 250.38 1.5121e-30 103466600.0 3625.1400000000003 4661.409999999999 4956.96 5045.599999999999 4362.41 3946.46 4706.25 4275.94 2136.42 4092.6999999999994 True False 3709.598708705476 4115.649950169282 4283.83205863225 4164.480677642262 3967.830785746039 3906.762195498983 4351.253773476389 4162.528180989413 3625.3487020568955 4618.0379112739265 0.8032845940154161 0.8912118153300184 0.9276303358563197 0.9017857275436384 0.8592027311121571 0.8459788054059669 0.9422299810172102 0.901362929660563 0.7850409138492349 1.0 12.173064301468871 -11.201904554456585 2.811538415623578 1.0152919643116045 0.8777231125369401 0.3788335983797576 0.048428764195182696 29796965.732011434 28177994.223589364 3270578.2229678105 0.012531981154642218 6.28196403300356e-12 11.201904554456585 -0.13756885177466438 GPGGSQGSQGPS(ph)PQGAR ddPTM_A459_Selumetinib_30min_R2 6 GPGGSQGSQGPSPQGAR 17 0 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 1 GPGGSQGSQGPS(1)PQGAR;GPGGSQGSQGPS(1)PQGAR;GPGGSQGS(0.004)QGPS(0.996)PQGAR;GPGGSQGS(0.013)QGPS(0.987)PQGAR;GPGGSQGS(0.001)QGPS(0.999)PQGAR;GPGGS(0.003)QGS(0.007)QGPS(0.99)PQGAR 215.49 2.7579000000000004e-10 124405400.0 25967.8 23496.25 25698.4 33318.0 28263.799999999996 21349.030000000002 23379.36 30260.51 27926.9 29530.22 True False 24524.61363333971 25298.33682264849 24044.992922302332 28780.030923244158 24713.04876242209 24289.66509530132 24466.546565322962 30348.563074202906 33513.06034278221 28677.605819874127 0.8551834413019126 0.8821634895726288 0.8384588683354695 1.0035716058032658 0.8617542523475051 0.846990688409146 0.853158618575027 1.05826697196496 1.1686143032050822 1.0 14.80763696370175 -7.821188868368081 5.352936557191316 1.0913050764637322 0.8790779408023245 0.7050866491474213 0.05872969945166183 0.10438640214851817 5.934705578637112 0.03229485491204769 0.015361998079538483 1.509423584994605e-08 7.821188868368081 -0.21222713566140772 GPGMGVHVPATPQGS(ph)PMK ddPTM_A459_Selumetinib_30min_R2 1 GPGMGVHVPATPQGSPMK 18 0 E9PJJ0;B3KNB6;G3V147;E9PNS0;A0A2R8YFB7;Q5QJ74 E9PJJ0 TBCEL Tubulin-specific chaperone cofactor E-like protein 1 GPGMGVHVPAT(0.024)PQGS(0.976)PMK 72.145 0.040795 0.0 20975.0 13248.0 16508.0 19232.0 17695.0 14718.0 19905.0 19081.0 18555.0 17160.0 True False 19809.29346957771 14264.07900096598 15445.893252551406 16612.56842294952 15471.995904692898 16745.27090329841 20830.62194100924 19136.522550970403 22266.518470017214 16664.546212965575 1.1887088442987674 0.8559536406618771 0.9268715184415873 0.9968809357691591 0.9284378768535063 1.0048440977210664 1.24999635002376 1.1483374528423431 1.3361611042665607 1.0 14.024494411956042 -7.175943995546732 5.250871626599791 1.1954828777529862 0.9707783963054745 0.4248975932291159 0.11347357535701011 0.1918133237535457 8.833301771165802 0.041804284274666446 0.03203319561389576 6.66892762837908e-08 7.175943995546732 -0.22470448144751176 GPGPGQGS(ph)PGGGPGPR ddPTM_A459_Selumetinib_30min_R2 4 GPGPGQGSPGGGPGPR 16 0 H0YDS2;Q8IYL2 H0YDS2 TRMT44 Probable tRNA (uracil-O(2)-)-methyltransferase 1 GPGPGQGS(1)PGGGPGPR;GPGPGQGS(1)PGGGPGPR;GPGPGQGS(1)PGGGPGPR;GPGPGQGS(1)PGGGPGPR 130.87 0.00075041 9310200.0 28630.1 31844.500000000004 26715.1 28441.8 27958.9 22978.9 26729.4 30926.6 24359.1 29704.2 True False 27038.953657371007 34286.87075379391 24996.2795512016 24567.977775158342 24446.453026262683 26144.034893314558 27972.37006330129 31016.591285825758 29231.600650121072 28846.562565219807 0.9373371123938272 1.1885946783528885 0.8665254133724591 0.8516778288439768 0.8474650305730944 0.9063137014750008 0.9696950893215773 1.0752265964341396 1.0133477978192627 1.0 14.816111793201035 -7.565738134305228 5.941921972492567 1.032436075414386 0.9342127191486665 0.17498658993292515 0.09364248787338647 0.36732959897304535 32.12195235347929 0.04874778285209204 0.028046970474040603 2.7180776888225872e-08 7.565738134305228 -0.09822335626571943 GPGQPS(ph)SPQRLDR ddPTM_A459_Selumetinib_30min_R2 1 GPGQPSSPQRLDR 13 1 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 GPGQPS(0.5)S(0.5)PQRLDR 116.9 0.017661000000000003 5501100.0 21059.0 17831.0 20869.0 18261.0 23206.0 14623.0 13310.0 15448.0 12599.0 17785.0 True False 19888.625085856358 19198.580364298352 19526.311260449198 15773.820298017945 20290.654815727798 16637.18551562253 13928.941373264657 15492.951122445933 15119.152045472756 17271.50083902055 1.1515284786903452 1.1115756843159834 1.1305509256227737 0.9132860221609127 1.1748055368695138 0.9632738735729932 0.8064696579115908 0.8970240204860229 0.8753814845849927 1.0 14.076105833518346 -6.964653225222085 6.213502032154168 0.8856389606438467 1.0880987677938898 0.5874671802711087 0.08006963697601804 0.12505637772323283 13.650424653185041 0.028109786216813298 0.02444552821038314 1.084792751916798e-07 6.964653225222085 0.20245980715004308 GPGQPSS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 GPGQPSSPQR 10 0 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 GPGQPSS(1)PQR;GPGQPS(0.005)S(0.995)PQR 133.89 0.0021938 19361200.0 10452.1 15578.4 8012.7 8489.3 10142.1 9960.5 11770.0 11342.8 6201.1 11123.0 True False 10695.613593753764 13754.473685798326 6924.619350610584 7006.803118897353 9224.748845733193 9860.306413410397 10882.179423918635 11041.952097393014 10522.813789575566 12550.745397194984 0.852189511879045 1.0959089082368263 0.5517297285114392 0.5582778470243952 0.7349960941598631 0.7856351237603877 0.867054432189401 0.8797845664099619 0.8384214209243184 1.0 13.615485428896992 -7.266754818100453 2.5054679065983954 0.8927156030916755 0.7550336488541575 0.16498985552418388 0.14859510299681492 0.6689380931275133 8.285349918915719 0.07729753769025301 0.05118164372761306 5.410596931718167e-08 7.266754818100453 -0.13768195423751806 GPGQPSS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 3 GPGQPSSPQR 10 0 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 GPGQPS(0.015)S(0.985)PQR;GPGQPS(0.004)S(0.996)PQR;GPGQPS(0.001)S(0.999)PQR 131.42 0.0026131 73441300.0 91910.0 71324.0 89005.0 94978.0 98985.0 84196.0 104729.0 102025.0 99649.0 91117.0 True False 86802.01014488145 76794.32145719341 83278.5152013168 82041.83255381139 86549.61936287238 95793.2347448098 109599.1060165766 102321.87585885206 119581.58442569339 88486.21545960277 0.9809664668561826 0.8678676227513974 0.9411467624506613 0.927170770358763 0.9781141493432441 1.082578051815799 1.2386008989910144 1.1563594999219486 1.3514148368147445 1.0 16.4331651066434 -6.87930447369506 2.049783974240001 1.2006367060660006 0.9270372166157874 0.6475429083182793 0.08629386666390028 0.18057345841684966 1.55132330573015 0.03373600721028166 0.028596679995317058 1.3203696293851288e-07 6.87930447369506 -0.2735994894502132 GPGSWWT(ph)STESLCSNASGDSR ddPTM_A459_Selumetinib_30min_R1 1 GPGSWWTSTESLCSNASGDSR 21 0 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ES05 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 GPGSWWT(0.574)S(0.414)T(0.011)ESLCSNASGDSR 153.04 2.1511e-06 5387800.0 1922.4 1907.5 2065.4 2653.6 2038.4 2014.8 1969.3 2279.9 1049.2 1550.8 True False 1967.1881796607588 1684.169013227308 1784.9300244301035 2190.198574241222 1854.0270799087502 1994.5329412920316 1820.7541155074732 2219.4296458410913 1780.4157694639134 1749.8602860712012 1.1241972832456835 0.9624591326708809 1.0200414505306827 1.2516419691761058 1.0595286347525636 1.1398241089122443 1.040513994174611 1.2683467723152746 1.017461670303585 1.0 10.773024022354686 GPGSWWTS(ph)TESLCSNASGDSR ddPTM_A459_Selumetinib_30min_R1 1 GPGSWWTSTESLCSNASGDSR 21 0 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ES05 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 GPGSWWT(0.015)S(0.966)T(0.015)ES(0.003)LCSNASGDSR 114.56 7.8291e-05 3736300.0 516.68 643.14 615.05 697.03 650.89 658.93 680.61 737.72 449.12 628.89 True False 528.7176387157311 567.8408698123258 531.5295882278184 575.3067953735904 592.0171144239631 652.3017624605711 629.2710397377452 718.1532691477213 762.1238375730399 709.6141574073501 0.7450776357780918 0.8002107397166257 0.749040281509909 0.8107318454236231 0.8342803032382553 0.9192344257107611 0.886779150569449 1.0120334574095444 1.0739975092345104 1.0 9.470890982696718 -7.138896435094584 0.7635528377425169 1.0441749786143009 0.7643495134147097 0.8955718633581174 0.0353352934484955 0.1957956959928061 0.23076211620179227 0.028145735801916708 0.01926797341436939 7.262791303970545e-08 7.138896435094584 -0.2798254651995912 GPHHLDNS(ph)SPGPGSEAR ddPTM_A459_Selumetinib_30min_R1 2 GPHHLDNSSPGPGSEAR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GPHHLDNS(0.5)S(0.5)PGPGSEAR;GPHHLDNS(0.5)S(0.5)PGPGS(0.001)EAR 199.75 3.8917e-08 24782630.0 2674.7799999999997 3333.72 2977.53 2816.26 2891.0099999999998 2668.48 3213.92 2884.7799999999997 1401.6100000000001 2395.45 True False 2737.097169784126 2943.4065125956186 2573.1977804015523 2324.453058747583 2629.518655949272 2641.637513985984 2971.4914268581624 2808.2662633139444 2378.4298004558887 2702.929341158924 1.0126410365616705 1.0889690928189732 0.9520033473380598 0.8599755174328517 0.9728403239804353 0.9773239254761057 1.0993596397840306 1.0389713932032922 0.8799452372795283 1.0 11.400308082701166 -7.051408251520278 24.99900050054095 1.0121773977993183 0.9755197205471552 0.027646303248522353 0.07356066124630592 1327.9635387350256 645763.7230346531 0.030245285483207873 0.02342808525377481 8.883656314488414e-08 7.051408251520278 -0.03665767725216307 GPHHLDNS(ph)SPGPGSEAR ddPTM_A459_Selumetinib_30min_R2 1 GPHHLDNSSPGPGSEAR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GPHHLDNS(0.5)S(0.5)PGPGSEAR 157.14 2.8231e-05 2468900.0 7619.7 6105.5 8600.5 8233.3 10974.0 6051.6 6766.8 6809.2 7649.6 7962.6 True False 7196.227578075869 6573.772217723271 8047.1531935163775 7111.910336765299 9595.348011195249 6885.1529690447505 7081.469608159828 6829.0136446762535 9179.733747682223 7732.699048680627 0.9306229988743333 0.8501264792976657 1.0406655092686432 0.9197190129853496 1.2408795364708305 0.8903945343921684 0.9157823889923773 0.8831345435383829 1.1871319043831783 1.0 12.916756350105421 -5.262225892428954 24.998007476506228 1.0029654402525798 0.8903747362711307 0.14086649361881132 0.11694137309258293 139.07801773028353 4420531.314028901 0.03004924669873215 0.06915499120755156 5.467315138865389e-06 5.262225892428954 -0.1125907039814491 GPHHLDNSS(ph)PGPGSEAR ddPTM_A459_Selumetinib_30min_R1 4 GPHHLDNSSPGPGSEAR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GPHHLDNS(0.033)S(0.966)PGPGSEAR;GPHHLDNS(0.234)S(0.766)PGPGSEAR;GPHHLDNS(0.25)S(0.747)PGPGS(0.003)EAR;GPHHLDNS(0.189)S(0.81)PGPGS(0.001)EAR 202.79 3.2382e-08 17942100.0 2821.8100000000004 3166.54 2460.0 2951.38 2752.7999999999997 2398.5499999999997 2976.0600000000004 2547.6899999999996 1445.74 2328.29 True False 2887.552682713552 2795.8000247154923 2125.9455118127503 2435.9768872641175 2503.8097260463132 2374.422764709153 2751.573398160347 2480.1169851365817 2453.3151873282122 2627.1487009651255 1.099120381595744 1.0641955758683967 0.8092216139237759 0.9272322066768516 0.95305215312955 0.9038021958318806 1.0473611170732406 0.9440337291244575 0.9338318711944045 1.0 11.359282146372104 -5.028577216500941 23.633519061168613 0.9401500786993335 1.0903892575756031 0.4903995186241219 0.05831313853842445 245.1768777965023 202764.2835718434 0.01493428101695201 0.039733427179301235 9.36316730260261e-06 5.028577216500941 0.15023917887626959 GPHHLDNSS(ph)PGPGSEAR ddPTM_A459_Selumetinib_30min_R2 2 GPHHLDNSSPGPGSEAR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GPHHLDNS(0.199)S(0.801)PGPGSEAR;GPHHLDNS(0.175)S(0.825)PGPGSEAR 184.32 4.0988e-08 35581900.0 47863.9 45688.9 50543.1 56284.7 67206.6 48608.8 45874.8 47058.9 47776.9 64056.8 True False 45203.816052372895 49193.09171703165 47291.2119731664 48618.62676347686 58763.50607337297 55304.22097324713 48008.06909919168 47195.833607979745 57333.614998122626 62207.313744445986 0.7266640099277523 0.7907927341007186 0.7602194842787062 0.781558048997376 0.9446398266734273 0.889030849337789 0.7717431634552449 0.7586862503316743 0.9216539269587333 1.0 15.924796588242073 -14.52287874526187 0.0765855358727004 1.585707062945463 0.626774801815503 0.4971530003083263 0.06407058731721513 273.23948738212005 1.4849318478823526 27.69619346296601 2.836298299210919 3.0000000001275665e-15 14.52287874526187 -0.95893226112996 GPHHLDNSSPGPGSEAR ddPTM_A459_Selumetinib_30min_R1 1 GPHHLDNSSPGPGSEAR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 0 66.24600000000001 0.023458 1164300.0 532.4 430.86 428.89 451.64 441.26 415.95 466.16 494.55 166.16 375.12 False True 544.8038841299358 380.41471089862046 370.6490937241345 372.7695523327955 401.3481109107804 411.76592065238265 430.9971758924308 481.4329274752013 281.9613841537592 423.27030597822375 1.2871299413995856 0.898751236563691 0.8756794145233602 0.8806891177288814 0.9482075762041026 0.9728202400136404 1.0182551665096125 1.1374124777370278 0.6661496924574374 1.0 8.725435471436965 -4.757472572771015 24.962936360432135 0.938342449160079 1.2871304553048608 0.4564868231119942 0.11576249775734164 105.49500915665116 663782.0702342393 0.028062084561520192 0.20761262086303936 1.7479436477417228e-05 4.757472572771015 0.3487880061447818 GPHHLDNSSPGPGSEAR ddPTM_A459_Selumetinib_30min_R2 2 GPHHLDNSSPGPGSEAR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 0 ; 136.14 0.00029033 889420.0 3604.1 4233.2699999999995 4986.5 6456.6 4912.6 4202.9 3183.5 3544.8999999999996 2428.1 5689.9 False True 3403.798550355425 4557.94819689155 4665.674018890696 5577.199941743754 4295.4352687987775 4781.811324872456 3331.539057985578 3555.215072110215 2913.787846782474 5525.617802864378 0.6160032546208605 0.824875762223148 0.8443714685572529 1.0093350898885254 0.7773674224395511 0.8653894452116564 0.6029260757518499 0.6434058957655843 0.5273234506505354 1.0 12.431920061618639 -7.256018496105159 24.95028660917932 0.6636976785037259 0.8303625975597375 0.1429446961909303 0.14766344782365706 660.5834581321973 3040426.5646118512 0.05581282299581103 0.04196636951163872 5.546020925862641e-08 7.256018496105159 0.16666491905601166 GPIHS(ph)PVELK ddPTM_A459_Selumetinib_30min_R2 2 GPIHSPVELK 10 0 Q16649 Q16649 NFIL3 Nuclear factor interleukin-3-regulated protein 1 GPIHS(1)PVELK;GPIHS(1)PVELK 82.774 0.027643 12182500.0 112346.0 116983.0 133700.0 132946.0 122286.0 93712.0 121851.0 128436.0 99164.0 133606.0 True False 106102.25907667118 125955.21994036867 125097.88756155362 114838.52545535797 106923.33942928926 106619.97736716253 127517.31294317586 128809.72749627556 118999.5708736615 129748.44762992274 0.8177535917755501 0.9707647547323774 0.9641571043560093 0.8850859301446762 0.8240818397632256 0.8217437612145558 0.9828041512056416 0.9927650761855382 0.9171560280480587 1.0 16.9853577520565 -7.287233421566942 24.771535124026055 0.9725784189980715 0.8861295678710698 0.4025404301658212 0.05500807388921584 842.6673818449211 809259.0743099122 0.02505258771545275 0.016896679277715074 5.1613888398339014e-08 7.287233421566942 -0.08644885112700174 GPKPEPPGS(ph)GSPAPPR ddPTM_A459_Selumetinib_30min_R1 2 GPKPEPPGSGSPAPPR 16 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GPKPEPPGS(0.931)GS(0.069)PAPPR;GPKPEPPGS(0.778)GS(0.222)PAPPR 95.429 0.0047846 122381000.0 13787.099999999999 15824.8 20341.0 22106.1 17427.4 16922.0 14874.5 14553.2 9285.5 12233.0 True False 14108.312604973395 13972.025059250072 17578.803925115106 18245.684617890376 15851.094747057368 16751.78004394667 13752.504489471341 14167.201860544139 15756.815313912673 13803.224709510583 1.0221026536829907 1.0122290517826016 1.2735287800540627 1.3218421783222065 1.1483617111685342 1.2136135139786934 0.9963254803781978 1.0263689941077878 1.1415314642422683 1.0 13.752717728360498 -7.260640106573205 24.997093025110342 1.0432538998516692 1.1695907002474388 0.27579993078930065 0.0984400783281036 109.7079998859269 3431163.1957980627 0.04322289179925265 0.03146876275188593 5.487315022570781e-08 7.260640106573205 0.12633680039576967 GPKPEPPGS(ph)GSPAPPR ddPTM_A459_Selumetinib_30min_R2 1 GPKPEPPGSGSPAPPR 16 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GPKPEPPGS(0.5)GS(0.5)PAPPR 73.758 0.018617 10781000.0 46051.0 39241.0 48620.0 50847.0 50072.0 39444.0 37403.0 38163.0 35541.0 43693.0 True False 43491.66977675918 42250.658520297875 45491.84213345346 43921.55088403253 43781.507710640464 44877.05296301823 39142.31361263845 38274.04801177525 42650.19309851157 42431.4695619525 1.0249861771405 0.9957387513672928 1.0721250666803475 1.035117363067155 1.0318169076542782 1.0576360759199026 0.9224831007912255 0.9020203261141554 1.0051547480871412 1.0 15.372847025018228 -7.259466964001816 24.99461267177816 0.9492495695498502 1.0357754155217795 0.5458593751860004 0.03490368673932367 123.9378900150918 1570563.3300803322 0.01364661805729056 0.010056945022058025 5.502157728406531e-08 7.259466964001816 0.08652584597192936 GPKPEPPGS(ph)GSPAPPRR ddPTM_A459_Selumetinib_30min_R1 1 GPKPEPPGSGSPAPPRR 17 2 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GPKPEPPGS(0.5)GS(0.5)PAPPRR 77.357 0.022586 17108000.0 2399.9 2380.5 2857.8 3407.3 2677.0 2443.0 2575.5 2681.2 1312.7 2143.4 True False 2455.8130006075003 2101.7899533355744 2469.726456771739 2812.279017942463 2434.8658226627354 2418.4256380665247 2381.227961453055 2610.0858662349815 2227.5560241853605 2418.5262684840186 1.0154171292697407 0.8690374715892663 1.0211699947008694 1.1628068938466634 1.0067559961583377 0.9999583918443206 0.9845780847961006 1.079205092889496 0.9210385899929207 1.0 11.239912492160899 -3.4385112959284987 9.37460511215212 1.008428335314379 0.9744004711882381 0.0 0.07538863992421839 0.0 0.0 0.01769960194153731 0.0 0.0003643247739174318 3.4385112959284987 -0.034027864126140894 GPKPEPPGSGS(ph)PAPPR ddPTM_A459_Selumetinib_30min_R1 3 GPKPEPPGSGSPAPPR 16 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GPKPEPPGS(0.012)GS(0.988)PAPPR;GPKPEPPGS(0.004)GS(0.996)PAPPR;GPKPEPPGS(0.006)GS(0.994)PAPPR 189.45 4.5679e-06 52201000.0 5950.299999999999 6731.9 6637.0 7269.8 6029.099999999999 6092.0 6203.5 5669.3 3828.44 4836.01 True False 6088.930412731701 5943.726018424593 5735.731854431393 6000.265901047196 5483.768969524059 6030.720011093436 5735.565000533499 5518.931747518267 6496.583061805591 5456.758990226463 1.1158510800344148 1.0892410731480595 1.0511242781117134 1.0996025134689296 1.0049498208269732 1.1051835021291923 1.051093700639226 1.0113937150977643 1.1905570822243652 1.0 12.413828609977275 -4.9532504739261425 3.0288177323556065 1.0647848765460959 1.1165753865022368 0.08232455808563477 0.05449790028390632 0.7409134942217086 12.473497896776232 0.01318000487461447 0.0766107700663443 1.1136520634025268e-05 4.9532504739261425 0.05179050995614087 GPKPEPPGSGS(ph)PAPPR ddPTM_A459_Selumetinib_30min_R2 1 GPKPEPPGSGSPAPPR 16 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GPKPEPPGS(0.231)GS(0.769)PAPPR 194.67 5.7981e-06 15934000.0 31925.0 34657.0 32397.0 39424.0 40643.0 32353.0 27700.0 31034.0 27912.0 33300.0 True False 30150.736305900773 37315.080460181016 30312.612291186557 34054.38318980667 35537.06298696994 36809.332078707244 28988.104886508692 31124.30380204471 33495.17992644141 32338.542476209397 0.9323467910800823 1.1538887532619235 0.9373524584012015 1.0530586904112815 1.0989073800439093 1.138249570331962 0.8963949104334082 0.9624522757926406 1.035766530018566 1.0 14.98096703641512 -7.265745355361595 24.999065397813016 0.9705244572684328 1.053846281495329 0.20269536775436692 0.07627723417033645 599.4398793754331 3480128.5813181205 0.030660221726113466 0.02145706671687276 5.423187809047387e-08 7.265745355361595 0.08332182422689627 GPLQS(ph)VQVFGR ddPTM_A459_Selumetinib_30min_R2 1 GPLQSVQVFGR 11 0 M0R3H0;M0R210;P62249;Q6IPX4 M0R3H0 RPS16 40S ribosomal protein S16 1 GPLQS(1)VQVFGR 81.789 0.041219 3159700.0 15105.0 13306.0 13967.0 11530.0 12490.0 11057.0 8400.6 12182.0 7393.7 16239.0 True False 14265.524570105912 14326.527414466587 13068.378426119792 9959.594109640597 10920.894537983282 12580.001384547528 8791.244545473111 12217.44760316134 8872.646597238821 15770.137876010942 0.9045909859676114 0.908459236507987 0.8286787679896582 0.631547687657876 0.6925046961444654 0.7977102979983356 0.5574614892141233 0.7747204050603864 0.5626232736199234 1.0 13.94490765300493 -5.56723213112878 4.71743047593293 0.7033718210779131 0.8996546734073547 0.2835280328407934 0.1219580764223655 0.21120549421869017 10.48945488906105 0.03084999296594516 0.05666785591276026 2.7087434169904144e-06 5.56723213112878 0.19628285232944165 GPLS(ph)PFNSR ddPTM_A459_Selumetinib_30min_R1 2 GPLSPFNSR 9 0 A1L390-3;A1L390;A0A0U1RR71;G3V3I3;G3V278 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 GPLS(0.865)PFNS(0.135)R;GPLS(0.798)PFNS(0.202)R 100.69 0.017694 166197000.0 8849.7 9789.400000000001 10947.0 11176.5 10875.9 8243.5 9265.9 9314.3 4875.700000000001 7563.1 True False 9055.880791481388 8643.25249703141 9460.457527566748 9224.734083888687 9892.176765296104 8160.577874499138 8566.965702981111 9067.254506889642 8273.706792961499 8533.89755583254 1.0611658661512868 1.0128141849000907 1.1085740677893356 1.0809520530960663 1.1591628210412768 0.956254492289018 1.0038749172851238 1.0624986353032297 0.9695109109092582 1.0 13.058989076642469 -6.775872514912296 24.999589129571813 1.0026744099375533 1.0816859764849913 0.49558557457536145 0.04328134735040769 233.38024955251285 404234.9064422157 0.015754600759247218 0.013956998076007691 1.675434619743687e-07 6.775872514912296 0.07901156654743802 GPLS(ph)PFNSR ddPTM_A459_Selumetinib_30min_R2 4 GPLSPFNSR 9 0 A1L390-3;A1L390;A0A0U1RR71;G3V3I3;G3V278 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 GPLS(0.908)PFNS(0.092)R;GPLS(0.949)PFNS(0.051)R;GPLS(0.577)PFNS(0.423)R;GPLS(0.77)PFNS(0.23)R 103.08 0.015556 215751400.0 151104.0 158294.0 184982.0 195929.0 203295.0 143960.0 155214.0 151534.0 135487.0 149241.0 True False 142706.24459723808 170434.64080456755 173080.4595131729 169243.13220362313 177755.2646196407 163789.18326123361 162431.75855070623 151974.93885219595 162588.18582307894 144932.02455531448 0.9846425938994117 1.1759626026580468 1.1942181863823709 1.1677414479160202 1.2264733426931393 1.1301103656267641 1.1207444251819778 1.0485946037012233 1.121823739935585 1.0 17.145016886187022 -8.275271631439907 0.7858266721966588 1.0109508718473192 1.153766941348776 0.28244089379389914 0.0656667362332962 0.7616477268964005 1.0308760085374318 0.0634311287471587 0.024740325378364035 5.305525039816551e-09 8.275271631439907 0.14281606950145687 GPLS(ph)SAPEIVHEDLK ddPTM_A459_Selumetinib_30min_R2 1 GPLSSAPEIVHEDLK 15 0 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;E5RIY8;H0YBX5;E5RIU4 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 GPLS(0.5)S(0.5)APEIVHEDLK 65.949 0.042712 2408600.0 18245.0 14584.0 15606.0 15406.0 14573.0 10980.0 14302.0 13905.0 14245.0 18454.0 True False 17231.015940521836 15702.54590504891 14601.926950528072 13307.676223167644 12742.209455727014 12492.395333483923 14967.071338875354 13945.461247903322 17094.39803855538 17921.185070749798 0.9614886444449242 0.876200197869612 0.8147857908325896 0.7425667538520023 0.7110137753403546 0.6970741769679888 0.8351608043657769 0.7781550825377344 0.9538653817294781 1.0 14.129378420916185 -8.356746974704045 3.875550819208982 0.9967725842632235 0.797347854611138 0.46796890826854864 0.07495127243103185 0.21763201582312253 5.581170862575676 0.07885409733157606 0.021016792668312256 4.397977723910303e-09 8.356746974704045 -0.19942472965208546 GPLSPFNS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GPLSPFNSR 9 0 A1L390-3;A1L390;A0A0U1RR71;G3V3I3;G3V278 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 GPLS(0.231)PFNS(0.769)R 89.9 0.029256 10482000.0 21052.0 20266.0 24085.0 25570.0 24697.0 17188.0 20882.0 20783.0 16190.0 23258.0 True False 19882.014117833143 21820.337034539294 22535.39732176523 22087.321889289673 21594.342066018668 19555.490982870822 21853.054376898017 20843.475089189138 19428.452386396053 22586.481108458807 0.8802616938141453 0.9660795291554918 0.9977383025515009 0.9779000891386221 0.9560737665298126 0.8658051198399003 0.9675280656584386 0.9228296780317453 0.8601805785107425 1.0 14.463171901151625 -6.560366784988714 24.999870128784835 0.9200703647590255 0.9602332513050881 0.09589365155530027 0.048299557014857074 340.2686961012714 226914.8515381794 0.01567522998870702 0.015675284186924307 2.751903591420212e-07 6.560366784988714 0.04016288654606259 GPMSTTVAGSQEGS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 GPMSTTVAGSQEGSK 15 0 O95490-6;O95490-7;A0A6I8PRJ0;H0Y5C0;A0A6I8PTT2;B1ALU3;A0A6I8PRM6;O95490;O95490-2;O95490-5;O95490-3;A0A6I8PUE4;A0A6I8PRQ0;A0A6I8PLG0;O95490-4;A0A6I8PIV6 O95490-6 LPHN2;ADGRL2 Latrophilin-2 1 GPMSTTVAGSQEGS(1)K;GPMSTTVAGSQEGS(1)K 80.361 0.015288 20256200.0 14004.7 34284.0 194836.0 224331.0 394750.0 202609.0 44848.0 114267.0 302660.0 170288.0 True False 13226.374839256026 36913.47255956509 182300.46388139742 193776.73080744047 345157.97589022404 230516.55064861986 46933.52086462611 114599.49805207984 363200.4570269693 165371.34297864136 0.07997984778393126 0.22321565450631112 1.1023703417885562 1.1717672924290627 2.087169213681739 1.3939328694838764 0.2838068556454055 0.6929828106123623 2.196272041364982 1.0 17.33534972753992 -5.265647172351184 3.0886732319083845 1.2433593775172957 0.09034370218389304 0.3968743056642615 0.5413955215265781 0.27566955559688017 5.335541198991586 0.1545577187783184 0.44700505620357056 5.424413993399877e-06 5.265647172351184 -1.1530156753334027 GPPAS(ph)SPAPAPK ddPTM_A459_Selumetinib_30min_R1 2 GPPASSPAPAPK 12 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 GPPAS(0.627)S(0.373)PAPAPK;GPPAS(0.636)S(0.364)PAPAPK 142.19 0.00092908 627502000.0 10691.4 13941.300000000001 14285.7 14978.0 13138.9 11181.3 12527.9 11164.400000000001 7100.299999999999 9808.5 True False 10940.488818157015 12309.046114865469 12345.780405733092 12362.373471881605 11950.488814861206 11068.826273808114 11582.910416729837 10868.283844917893 12048.69051460602 11067.516517880695 0.9885224748010583 1.112177794808705 1.1154969035544002 1.1169961618678352 1.0797805266930462 1.0001183423512676 1.0465681617024445 0.9819984300325262 1.088653492871697 1.0 13.434043906158644 -6.672413231751991 6.460248252445632 1.0239522709275355 1.0887575382380625 0.3034409465626333 0.04442803293274894 0.25358827368480047 15.143422375225796 0.014447854751515185 0.014389432700576152 2.126115082028124e-07 6.672413231751991 0.06480526731052705 GPPAS(ph)SPAPAPK ddPTM_A459_Selumetinib_30min_R2 1 GPPASSPAPAPK 12 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 GPPAS(0.588)S(0.412)PAPAPK 92.247 0.023517 0.0 14230.0 68058.0 17344.0 25985.0 17406.0 12527.0 14490.0 11015.0 7502.0 21201.0 True False 13439.153567203377 73277.82975903852 16228.105922719376 22445.798173374744 15219.302668385677 14252.480541216124 15163.813711390294 11047.051826368592 9002.609623393648 20588.872043186657 0.6527386997701368 3.5590987988721743 0.7881979104382087 1.0901907654918175 0.7392004106131741 0.6922419310451058 0.7365053160553473 0.5365544942528467 0.4372560869051019 1.0 14.329577173954988 -5.464642697213127 24.99895340604283 0.7414889556150365 2.1228538058984503 0.39184818781440567 0.6744976006603678 225.22844456286066 96682.98412660793 0.16067619469053707 0.3344728841271195 3.430499045201917e-06 5.464642697213127 1.381364850283414 GPPASS(ph)PAPAPK ddPTM_A459_Selumetinib_30min_R1 4 GPPASSPAPAPK 12 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 GPPAS(0.45)S(0.55)PAPAPK;GPPAS(0.12)S(0.88)PAPAPK;GPPAS(0.039)S(0.961)PAPAPK;GPPAS(0.029)S(0.971)PAPAPK 158.3 0.00045275 817602800.0 38534.2 47229.1 49830.0 54530.8 48299.8 40449.4 46652.8 42155.1 25553.800000000003 35720.7 True False 39431.97188549921 41699.49501578707 43063.35969659731 45008.019449891945 43931.091618022285 40042.5157611167 43133.741735615244 41037.009808937146 43362.9322242918 40305.79979408277 0.9783200454265184 1.0345780316685071 1.0684159579167902 1.1166635987831086 1.0899446690665033 0.9934678375243475 1.0701621591924753 1.018141558251915 1.0758484497473697 1.0 15.298699829521667 -4.817859126304975 3.063207466808905 1.0564876797605913 0.9694016599802935 0.2670605125835722 0.037555767932615176 0.4502857983458456 6.543008854837317 0.009793122092429716 0.09235405480960979 1.521040835318714e-05 4.817859126304975 -0.08708601978029784 GPPASS(ph)PAPAPK ddPTM_A459_Selumetinib_30min_R2 8 GPPASSPAPAPK 12 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 GPPAS(0.022)S(0.978)PAPAPK;GPPAS(0.04)S(0.96)PAPAPK;GPPAS(0.039)S(0.961)PAPAPK;GPPAS(0.008)S(0.992)PAPAPK;GPPAS(0.04)S(0.96)PAPAPK;GPPAS(0.036)S(0.964)PAPAPK;GPPAS(0.041)S(0.959)PAPAPK;GPPAS(0.047)S(0.953)PAPAPK 162.68 0.00042631 1369746900.0 495185.0 474185.0 472937.0 481972.0 485428.0 339104.0 416938.0 395942.0 330813.0 364014.0 True False 467664.60008261487 510553.4647549116 442508.74831487297 416326.5821519252 424444.19485861866 385812.4979203767 436326.4431469732 397094.1256682732 396984.84368751297 353503.96999804483 1.322940164109618 1.4442651514146656 1.2517787234958646 1.1777140215829198 1.2006773074174137 1.091395092175374 1.2342900792581946 1.1233088150904484 1.1229996757595357 1.0 18.431366891633665 -1.5228787452808477 0.179620958051915 1.0122215265402423 2.6776855272289994 0.734700705244781 0.06151727559550122 29.255881560695425 0.3291742262233996 0.1427488288248738 13.288839217968608 0.029999999999964763 1.5228787452808477 1.665464000688757 GPPASS(ph)PAPAPKFS(ph)PVTPK ddPTM_A459_Selumetinib_30min_R2 2 GPPASSPAPAPKFSPVTPK 19 1 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 2 GPPAS(0.171)S(0.83)PAPAPKFS(0.981)PVT(0.018)PK;GPPAS(0.42)S(0.58)PAPAPKFS(0.944)PVT(0.055)PK 69.704 0.033841 18579300.0 142227.0 164351.0 148814.0 149945.0 130952.0 91687.0 97015.0 99607.0 64524.0 136655.0 True False 134322.5927197918 176956.19322824292 139239.46925643212 129522.23233044714 114500.63903426628 104316.05199828242 101526.38973157546 99896.83987917347 77430.60295119314 132709.41507766966 1.0121557136031232 1.3334109951782798 1.0492056586560996 0.9759837480606994 0.8627921309671474 0.7860486155954367 0.765027783990729 0.7527487015198411 0.58345975608344 1.0 17.01791120086478 -6.0569680292955965 1.2332926836310574 0.7574457611103776 1.1772208908365713 0.6195970242529845 0.12203086778263027 0.2754234500955277 0.8529616133876894 0.04442685149532752 0.0796009105947371 8.770653841699517e-07 6.0569680292955965 0.4197751297261937 GPPASSPAPAPKFS(ph)PVTPK ddPTM_A459_Selumetinib_30min_R1 2 GPPASSPAPAPKFSPVTPK 19 1 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 GPPASSPAPAPKFS(0.949)PVT(0.051)PK;GPPASS(0.001)PAPAPKFS(0.92)PVT(0.08)PK 103.02 0.00057048 288570000.0 6859.8 5164.6 12645.4 13097.900000000001 9042.6 8262.8 6281.299999999999 5875.0 4394.4 4591.1 True False 7019.619993152767 4559.926231042597 10928.224136210154 10810.597643033649 8224.698426600697 8179.683734022135 5807.496483896355 5719.175915310504 7456.975845722672 5180.412406101041 1.3550311139100948 0.8802245600509162 2.1095278289697244 2.086821819494885 1.5876532179010228 1.5789638146161513 1.1210490649464102 1.104000119483722 1.4394560241845789 1.0 12.33885123827923 -7.233634981076764 7.003066224814476 1.174564481826511 1.6128522130018608 0.2752671879642812 0.3441943746275078 0.3085618103005561 59.17035504992481 0.1472991988672888 0.11142079938550177 5.839356885116985e-08 7.233634981076764 0.4382877311753497 GPPASSPAPAPKFS(ph)PVTPK ddPTM_A459_Selumetinib_30min_R2 1 GPPASSPAPAPKFSPVTPK 19 1 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 GPPASSPAPAPKFS(0.989)PVT(0.011)PK 92.29 0.0012559 66781000.0 108300.0 150220.0 133920.0 137710.0 115180.0 83409.0 56599.0 54812.0 38050.0 122880.0 True False 102281.1195592499 161741.39096656966 125303.733001071 118953.66043699968 100710.05867773548 94897.83263848457 59230.965648790814 54971.49384538493 45661.06320582891 119332.135119418 0.8571129600328963 1.3553883939536646 1.050041825495514 0.9968283926032198 0.8439475131904156 0.7952412193372594 0.4963538579907016 0.46065960179438575 0.3826384499040011 1.0 16.864623075177654 -6.644279745708359 1.243082039052697 0.5432431980004749 1.1057056842559347 0.5286441344305659 0.19788990170784432 0.30730368142414716 0.999678872632254 0.08952287399625042 0.09006504711703855 2.268403215800101e-07 6.644279745708359 0.5624624862554598 GPPDFS(ph)S(ph)DEEREPTPVLGSGAAAAGR ddPTM_A459_Selumetinib_30min_R1 1 GPPDFSSDEEREPTPVLGSGAAAAGR 26 1 P42166;G5E972;P42167;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 2 GPPDFS(1)S(1)DEEREPT(0.001)PVLGSGAAAAGR 62.082 0.0076563 7593700.0 1906.6 1914.5 1899.9 2938.1 2346.5 1842.3 1989.9 1750.2 1222.7 1672.4 True False 1951.020070402208 1690.349449973097 1641.9040154036782 2425.015989967643 2134.259489308223 1823.7681346745637 1839.80024092232 1703.7790105491817 2074.8325975252856 1887.0688305555059 1.0338891930231693 0.8957539982659246 0.8700816784305333 1.2850702373446434 1.1309918614256111 0.9664555447814227 0.9749513166304213 0.9028706229266856 1.0995002216821665 1.0 10.881931330647644 GPPDFS(ph)S(ph)DEEREPTPVLGSGAAAAGR ddPTM_A459_Selumetinib_30min_R2 1 GPPDFSSDEEREPTPVLGSGAAAAGR 26 1 P42166;G5E972;P42167;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 2 GPPDFS(0.999)S(0.999)DEEREPT(0.001)PVLGSGAAAAGR 62.707 0.019998 0.0 29769.0 22642.0 25880.0 32895.0 31120.0 22400.0 23248.0 28512.0 20800.0 26226.0 True False 28114.55815474893 24378.568594495177 24214.908976013467 28414.644252959883 27210.427383670132 25485.396673045536 24329.07806503807 28594.965199584312 24960.581200558223 25468.787236668697 1.1038828780300534 0.9571939318491036 0.9507680421135264 1.115665382450951 1.0683833168347296 1.0006521486956759 0.9552507482574698 1.1227454583473335 0.9800459271425855 1.0 14.636442643075958 -7.1165636850438565 0.002061678538821566 0.19205459663188545 1.8585674695905585 0.012976877761598948 0.0659670075263882 640648.7845389203 683.6826915111546 275224.42474650923 277400.95359770523 7.646035585739613e-08 7.1165636850438565 1.6665128729586731 GPPDFS(ph)SDEEREPTPVLGSGAAAAGR ddPTM_A459_Selumetinib_30min_R1 4 GPPDFSSDEEREPTPVLGSGAAAAGR 26 1 P42166;G5E972;P42167;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 GPPDFS(0.566)S(0.434)DEEREPTPVLGSGAAAAGR;GPPDFS(0.833)S(0.166)DEEREPT(0.001)PVLGSGAAAAGR;GPPDFS(0.859)S(0.139)DEEREPT(0.001)PVLGSGAAAAGR;GPPDFS(0.567)S(0.433)DEEREPTPVLGSGAAAAGR 125.37 4.1152e-09 867580000.0 1884.85 2113.18 2372.12 2790.96 2230.8199999999997 2399.0099999999998 1923.63 2205.46 1233.13 1425.6100000000001 True False 1928.7633377203404 1865.76790320927 2049.9991331224655 2303.5712288077625 2029.0427248832596 2374.8781375268 1778.529040376601 2146.9640364562897 2092.5315457482247 1608.6009301173362 1.199031594231175 1.1598699641888028 1.2743988236864519 1.432034002765206 1.2613711001244137 1.4763625291162608 1.105637207512288 1.3346778534435408 1.300839447852109 1.0 10.651590744004643 -10.392128631189008 8.763567700716404 1.0000000001309926 1.2846182073411072 0.3809279420666881 0.10808915444868417 0.0 0.0 0.10467606733168604 0.025387675416635752 4.053884479884615e-11 10.392128631189008 0.28461820721011466 GPPDFS(ph)SDEEREPTPVLGSGAAAAGR ddPTM_A459_Selumetinib_30min_R2 4 GPPDFSSDEEREPTPVLGSGAAAAGR 26 1 P42166;G5E972;P42167;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 GPPDFS(0.55)S(0.45)DEEREPTPVLGSGAAAAGR;GPPDFS(0.544)S(0.453)DEEREPT(0.003)PVLGSGAAAAGR;GPPDFS(0.555)S(0.444)DEEREPT(0.001)PVLGSGAAAAGR;GPPDFS(0.541)S(0.456)DEEREPT(0.003)PVLGSGAAAAGR 91.565 1.7245e-05 1144990000.0 26905.5 29199.6 41489.6 37878.7 41736.0 22478.64 34833.6 31048.8 18025.9 35100.8 True False 25410.2000212502 31439.115428487803 38820.204306460924 32719.555715597842 36492.75055542597 25574.868619222678 36453.431421468944 31139.146867594463 21631.583685728005 34087.3487011691 0.7454437200150652 0.9223103769114647 1.1388449317892975 0.9598738817277288 1.0705658241520664 0.7502745034067589 1.0694123424218878 0.9135103800703185 0.6345927304397863 1.0 15.056948771211955 -8.01649188470584 24.608797897122056 0.8028814007524576 0.9569631826985291 0.11246584544177518 0.14645072393272338 1085.6485107048056 1619968.3129825096 0.09075530685073076 0.036326142560814 9.627380026771285e-09 8.01649188470584 0.15408178194607147 GPPDFSSDEEREPT(ph)PVLGSGAAAAGR ddPTM_A459_Selumetinib_30min_R1 2 GPPDFSSDEEREPTPVLGSGAAAAGR 26 1 P42166;G5E972;P42167;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 GPPDFS(0.004)S(0.005)DEEREPT(0.949)PVLGS(0.042)GAAAAGR;GPPDFS(0.013)S(0.01)DEEREPT(0.976)PVLGS(0.001)GAAAAGR 95.209 5.9063e-06 213380000.0 3709.3999999999996 7223.3 5830.299999999999 5630.4 5866.7 5686.5 6365.1 5422.9 2694.3 5103.1 True False 3795.821802764056 6377.5926779789315 5038.577283545478 4647.156335697834 5336.058020850011 5629.298972928893 5884.975382428588 5279.067075938269 4572.030316113823 5758.132593403372 0.6592105584912412 1.1075800312909128 0.8750366897278068 0.8070596257233996 0.9266994002470701 0.9776257982280447 1.0220284592214026 0.9168019301927973 0.7940126841385398 1.0 12.491385295106163 -6.502998618218214 23.440538601354323 0.9430312442942759 0.878939769715707 0.08785272843204794 0.11803244259806761 1100.536086005662 1297636.702899862 0.036483715036060654 0.04075081695606912 3.1405186859548543e-07 6.502998618218214 -0.0640914745785689 GPPDFSSDEEREPT(ph)PVLGSGAAAAGR ddPTM_A459_Selumetinib_30min_R2 2 GPPDFSSDEEREPTPVLGSGAAAAGR 26 1 P42166;G5E972;P42167;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 GPPDFS(0.002)S(0.001)DEEREPT(0.985)PVLGS(0.012)GAAAAGR;GPPDFSSDEEREPT(0.903)PVLGS(0.097)GAAAAGR 87.74799999999998 9.3563e-05 155018000.0 113518.0 56694.0 107994.0 99001.0 51643.0 40735.0 137832.0 91273.0 84475.0 64640.0 True False 107209.1240085589 61042.247500057805 101045.78361497665 85516.89301374918 45155.14464572227 46345.87649448704 144241.46110892668 91538.5893189415 101372.36042870952 62773.67524511039 1.7078675669369814 0.9724179325443041 1.609684047021723 1.3623050216485504 0.7193324983666545 0.738301147949706 2.297801754409179 1.458232116592085 1.6148864955394768 1.0 15.93787205720829 -7.242454402747934 24.99093882893759 1.6309162531077246 1.181521145818942 0.17765178311291552 0.42657965982613844 1344.3611704303996 1769656.7333596966 0.16363580088902577 0.1265476251515702 5.7219702735316815e-08 7.242454402747934 -0.4493951072887825 GPPEDRDAEPQPGS(ph)PAAESLEEPDAAAGLSSTK ddPTM_A459_Selumetinib_30min_R2 1 GPPEDRDAEPQPGSPAAESLEEPDAAAGLSSTK 33 1 Q9H9J4-2;Q9H9J4;C9JPC9 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 GPPEDRDAEPQPGS(0.989)PAAES(0.011)LEEPDAAAGLSSTK 68.441 7.0397e-05 3164500.0 19728.0 26377.0 25012.0 25905.0 26518.0 14523.0 11206.0 12528.0 8382.3 27278.0 True False 18631.596737441207 28400.031084577302 23402.755151006535 22376.694311382435 23186.571766072117 16523.41142333216 11727.101204267743 12564.454405877954 10058.994221030733 26490.413263244434 0.7033335626852084 1.0720871283643758 0.8834424332472745 0.8447091439841823 0.8752816173782985 0.6237506096689879 0.4426922708880177 0.47430194014040505 0.37972205722391017 1.0 14.693182730172149 -6.837204515542832 3.3912738080794007 0.5300575147624179 0.8884153737169687 0.38751728742861447 0.18023131016643096 0.20938978108098238 4.806459176733141 0.0629605295528504 0.05618077568801063 1.4547738452400554e-07 6.837204515542832 0.35835785895455075 GPPNS(ph)PDLK ddPTM_A459_Selumetinib_30min_R1 1 GPPNSPDLK 9 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 GPPNS(1)PDLK 82.505 0.04117 16154000.0 2802.2 2928.3 3230.9 3398.8 3061.5 2512.4 2706.2 3146.5 1806.6 2359.3 True False 2867.485807867968 2585.4532746702625 2792.161526063341 2805.2633833777004 2784.5878655517245 2487.1275370766834 2502.06915522588 3063.0445987275743 3065.6682511566028 2662.1391365281065 1.0771359650298629 0.9711938941110886 1.0488413200313815 1.0537628724531103 1.045996367110741 0.9342590336282465 0.9398716697013119 1.1505952324949922 1.1515807754341378 1.0 11.3783702602445 -7.773020283455756 24.99991682972951 1.113316012719549 1.0102783362166277 0.3111779363733257 0.06089485275880932 249.16025611841715 537858.5284001816 0.033370572763432894 0.01624585146263864 1.6864742578099443e-08 7.773020283455756 -0.10303767650292128 GPPQEEEEEEDEEEEATKEDAEAPGIR ddPTM_A459_Selumetinib_30min_R1 1 GPPQEEEEEEDEEEEATKEDAEAPGIR 27 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 199.85 1.6074999999999998e-39 9536300.0 348.01 381.1 363.15 464.2 296.85 446.23 376.38 425.33 257.47 446.55 False True 356.11795589041895 336.4806348314167 313.83622464016275 383.13618411319544 269.9999699131242 441.74133134442314 347.98935357472374 414.04886673344976 436.90778513522133 503.86904226534404 0.7067668898437356 0.6677938245990147 0.622852761958121 0.7603884183688961 0.5358534604531998 0.8766986940860645 0.690634518862677 0.8217390472570574 0.8671058320450257 1.0 8.9769050095627 -8.218849781333926 0.585705386507151 1.0032468972324562 0.6648136794474305 0.6165904000728155 0.0810771918170971 0.48884686544770173 0.39916617051139197 0.07732088060291424 0.03768909726527796 6.041575660620933e-09 8.218849781333926 -0.33843321778502566 GPPQEEEEEEDEEEEATKEDAEAPGIR ddPTM_A459_Selumetinib_30min_R2 4 GPPQEEEEEEDEEEEATKEDAEAPGIR 27 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 ;;; 171.78 2.4264999999999997e-21 31642800.0 51244.3 50885.0 51096.200000000004 45587.0 46995.7 36159.2 44815.7 48861.8 33991.7 48352.3 False True 48396.346953186236 54787.71587893674 47808.72612133614 39377.97195803865 41091.680019111365 41139.80157946373 46899.71885062482 49003.97974849356 40790.98980745268 46956.24346463721 1.0306690523409003 1.166782345359407 1.0181548308339643 0.8386099281492617 0.8751057790655155 0.876130596146307 0.9987962279381449 1.0436094570767465 0.868702153275366 1.0 15.519029375908051 -5.528053739157476 9.978807353626836 0.9289135613867573 1.0972627740587249 0.48734471694309056 0.07058464047808369 0.1067574052927195 152.41444589949754 0.01988137660252816 0.03572725581049247 2.964464547000516e-06 5.528053739157476 0.16834921267196756 GPPQS(ph)PVFEGVYNNSR ddPTM_A459_Selumetinib_30min_R1 4 GPPQSPVFEGVYNNSR 16 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GPPQS(1)PVFEGVYNNSR;GPPQS(0.997)PVFEGVY(0.003)NNSR;GPPQS(1)PVFEGVYNNSR;GPPQS(1)PVFEGVYNNSR 180.39 1.018e-06 731720000.0 18683.2 21958.7 16502.1 17997.600000000002 17232.7 16268.399999999998 18196.9 18520.3 10666.0 16656.5 True False 19118.482208821213 19387.765195677337 14261.205459546836 14854.657016793728 15674.005327680286 16104.754666525345 16824.293182591766 18029.08148158725 18099.42298618197 18794.52402304937 1.017236839058789 1.0315645755061646 0.7587957770070193 0.7903715464449199 0.833966601572771 0.8568854761511744 0.8951699527989463 0.9592731084584324 0.9630157679963092 1.0 14.198024758708964 -7.777603870880511 2.616383613856382 0.9780409546442209 0.8761187981430266 0.20492051954333845 0.082501661702807 0.5150450722648294 7.056316952708393 0.05965669446242924 0.02614186981289411 1.6687686375112375e-08 7.777603870880511 -0.1019221565011943 GPPQS(ph)PVFEGVYNNSR ddPTM_A459_Selumetinib_30min_R2 4 GPPQSPVFEGVYNNSR 16 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 GPPQS(0.993)PVFEGVY(0.007)NNSR;GPPQS(0.994)PVFEGVY(0.006)NNSR;GPPQS(1)PVFEGVYNNSR;GPPQS(1)PVFEGVYNNSR 199.91 7.727600000000002e-07 667120000.0 146528.0 125560.0 139733.0 150439.0 168538.0 111020.0 112184.0 113890.0 107165.0 124355.0 True False 138384.56035805892 135190.04826096704 130742.73090978725 129948.94867824997 147364.74969116296 126311.99726078207 117400.77828837882 114221.40104449556 128600.99444027973 120764.54803690761 1.1459038485016841 1.119451448778252 1.0826251001231764 1.0760521261466194 1.220264987421026 1.04593607407183 0.9721460494556666 0.945818975032206 1.0648902888368958 1.0 16.881837469845323 -6.99300847393206 24.901393148252193 0.993747636506168 1.12386113101594 0.6474717007154425 0.046528803547460945 104.05915352109811 370620.2458172495 0.016461557230347593 0.014485682763867429 1.0162288640708272e-07 6.99300847393206 0.13011349450977205 GPPS(ph)PGPAAQPPAPPR ddPTM_A459_Selumetinib_30min_R1 1 GPPSPGPAAQPPAPPR 16 0 H9KV50;Q9NZV5-2;Q9NZV5 H9KV50 SEPN1 Selenoprotein N 1 GPPS(1)PGPAAQPPAPPR 103.66 0.0042862 11183000.0 896.98 1056.3 780.18 1020.8 1097.2 842.34 1166.5 623.8 306.58 670.19 True False 917.8778887807468 932.6279049394524 674.2358412219808 842.5364427892072 997.9584537263931 833.8668243835265 1078.5099658454615 607.2547976120328 520.2438682827362 756.2154147034173 1.2137783374076452 1.2332833830228427 0.8915923004378477 1.1141487285334488 1.3196748364588493 1.1026842460101973 1.426194104054922 0.8030182746938505 0.6879572383310547 1.0 9.562653447311348 -7.789599217071726 24.84933491182906 0.8091152929797544 1.1755942691498833 0.5346885147801288 0.15140923919466778 157.88076611784166 139317.8227794329 0.08294564391491768 0.03985863309039614 1.6233074541949005e-08 7.789599217071726 0.3664789761701289 GPPS(ph)PGPAAQPPAPPR ddPTM_A459_Selumetinib_30min_R2 1 GPPSPGPAAQPPAPPR 16 0 H9KV50;Q9NZV5-2;Q9NZV5 H9KV50 SEPN1 Selenoprotein N 1 GPPS(1)PGPAAQPPAPPR 115.26 0.0020143 7246300.0 7071.2 6244.0 9678.9 9924.2 10422.0 2966.9 6417.5 11859.0 8534.9 8076.4 True False 6678.211012256395 6722.894722375575 9056.170111589518 8572.506839800102 9112.69518613786 3375.5635441633403 6715.926466035007 11893.50772663687 10242.11848503099 7843.213346992726 0.8514636433824639 0.857160761150695 1.1546504871070309 1.0929840182260253 1.1618573641926857 0.4303801764435761 0.8562723170867274 1.5164075233522907 1.3058574377500596 1.0 12.937229129051875 -7.747854413856513 24.99709114092947 1.308349382537388 0.9196668428310436 0.3333534290712781 0.2311418046666606 250.4436449636778 460832.0676156094 0.11505903045405648 0.06596705244428076 1.7870865496169323e-08 7.747854413856513 -0.38868253970634437 GPPS(ph)PPAPVMHS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 GPPSPPAPVMHSPSR 15 0 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 2 GPPS(1)PPAPVMHS(0.991)PS(0.009)R;GPPS(1)PPAPVMHS(0.71)PS(0.29)R 149.33 0.0011475 57468000.0 5013.1 5836.299999999999 5559.6 5913.1 6949.900000000001 4865.4 5562.7 5543.4 2793.6 4269.0 True False 5129.895476205452 5152.983282777743 4804.63685669682 4880.488087634074 6321.282772104501 4816.458493429744 5143.101060444534 5396.371024499105 4740.535163528774 4816.967733581352 1.0649636368627784 1.0697566535174956 0.9974401163622983 1.0131867925146958 1.3122950207940693 0.9998942820089787 1.0677051092930419 1.1202838223055678 0.9841326381491554 1.0 12.233909544738507 -8.275434929129188 24.071724100638647 0.9920662798778 1.0798951424242145 0.145303616234004 0.08595937841748197 1127.6875036979927 1939542.5635928877 0.08150654179879749 0.021523051615615116 5.303530501194617e-09 8.275434929129188 0.08782886254641442 GPPS(ph)PPAPVMHS(ph)PSRK ddPTM_A459_Selumetinib_30min_R2 1 GPPSPPAPVMHSPSRK 16 1 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 2 GPPS(1)PPAPVMHS(0.726)PS(0.274)RK 114.58 0.006971 6974700.0 34259.0 40120.0 37307.0 33714.0 40800.0 31432.0 29804.0 30987.0 25905.0 39646.0 True False 32355.021929643055 43197.07499386742 34906.70823679036 29122.095040106084 35674.33924337215 35761.47268871281 31189.945055505614 31077.167039826007 31086.723846176 38501.316967321276 0.8403614337947192 1.1219635689483494 0.9066367331387154 0.7563921791253014 0.9265745188314318 0.9288376477891923 0.8101007319302524 0.8071715330206326 0.8074197532661401 1.0 15.23262017470057 -5.514443124815195 24.902799559224178 0.855584705055094 0.989446924880336 0.199128343101574 0.09360561741656759 466.6018964494709 1377453.0362389276 0.0239669774122114 0.04430110877351129 3.0588408059286005e-06 5.514443124815195 0.13386221982524205 GPPS(ph)PPAPVMHSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 GPPSPPAPVMHSPSR 15 0 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 2 GPPS(1)PPAPVMHS(0.075)PS(0.925)R;GPPS(1)PPAPVMHS(0.001)PS(0.999)R 130.87 0.013825 199872000.0 222864.0 216283.0 253287.0 292050.0 336230.0 235677.0 209125.0 258633.0 245200.0 263270.0 True False 210478.11107527852 232871.21064054428 236990.79017803367 252272.2861856487 293989.7814656621 268139.3674872029 218849.72687332594 259385.57921100184 294246.85146042664 255668.71104239125 0.8232454812993527 0.9108318718043404 0.9269448311128666 0.9867155239962883 1.149885647981841 1.0487766234435467 0.8559894794362987 1.014537829652508 1.1508911288391441 1.0 17.963916087554402 -5.507271354864823 1.6717442198445132 1.0300957612267185 0.8535927103330134 0.41957163191342606 0.08045558685148996 0.447462090476333 2.382053477984694 0.026210394216568938 0.07936470971274814 3.109772689041038e-06 5.507271354864823 -0.1765030508937051 GPPS(ph)PPAPVMHSPSR ddPTM_A459_Selumetinib_30min_R1 1 GPPSPPAPVMHSPSR 15 0 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 1 GPPS(1)PPAPVMHSPSR 108.66 0.0039389 42514000.0 1817.2 1922.0 2372.7 2659.8 2614.1 1959.2 2545.2 2426.6 1113.6 1909.7 True False 1859.5372243443271 1696.9713464864406 2050.5003723081754 2195.315860629636 2377.65511655684 1939.49222681127 2353.2135148477223 2362.238685292334 1889.697865874013 2154.828597053246 0.8629629414085495 0.7875203386510969 0.9515839798637624 1.0187890877407868 1.103408001828225 0.900067981956221 1.0920652891212648 1.096253636378654 0.8769597119966746 1.0 11.073357401300878 -5.454347621809722 3.44634516321335 1.0180745049113857 0.8262166393300638 0.4905037132617641 0.07504954852867796 0.18658822211274442 4.279822367447659 0.019960832500691392 0.044351893179765914 3.5127915401771975e-06 5.454347621809722 -0.1918578655813219 GPPS(ph)PPAPVMHSPSR ddPTM_A459_Selumetinib_30min_R2 3 GPPSPPAPVMHSPSR 15 0 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 1 GPPS(1)PPAPVMHSPSR;GPPS(1)PPAPVMHSPSR;GPPS(1)PPAPVMHSPSR 117.29 0.0014273 92630000.0 134899.0 142410.0 159371.0 178584.0 168750.0 129003.0 123690.0 134646.0 120405.0 144458.0 True False 127401.85362348342 153332.38907967726 149117.24337002452 154260.55112541682 147550.1163558589 146771.99227736128 129441.83008708528 135037.7975681548 144489.36439678908 140287.1221930408 0.9081507385130709 1.0929897675759979 1.062943205612509 1.099605927571513 1.0517723512271064 1.0462256975761257 0.9226921763279744 0.9625815645596986 1.0299545827019378 1.0 17.098023055732902 -7.157942115614088 8.84578685922859 0.9757779384733355 1.0499216990062175 0.2397630358311943 0.05578063243984659 0.44871885206690415 35.02620525197833 0.021169178768075666 0.016392509897194183 6.951169591918689e-08 7.157942115614088 0.07414376053288196 GPPS(ph)PRPAGPTPR ddPTM_A459_Selumetinib_30min_R2 1 GPPSPRPAGPTPR 13 1 Q14681 Q14681 KCTD2 BTB/POZ domain-containing protein KCTD2 1 GPPS(0.917)PRPAGPT(0.083)PR 69.21600000000001 0.035499 27429000.0 45783.0 36519.0 43322.0 40424.0 45877.0 36889.0 34064.0 28821.0 29225.0 47548.0 True False 43238.56414387016 39319.889872907355 40534.709685427166 34918.18146471042 40113.52111441627 41970.12490499894 35648.043496535494 28904.864338426603 35070.81661472665 46175.16569545962 0.936403009986855 0.8515376021005521 0.8778465453219353 0.7562112867121538 0.8687250064023183 0.9089328489215545 0.7720176627333846 0.6259829045132979 0.7595168547099583 1.0 15.494829517748803 -7.370028033371742 6.571461158813791 0.7564520782381681 0.8612774935478967 0.09428600066318138 0.09787866285330857 0.4016066530979547 21.175986362147746 0.04000056430373878 0.02676961830203387 4.2655198431340534e-08 7.370028033371742 0.10482541530972866 GPPSPPAPVMHSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GPPSPPAPVMHSPSR 15 0 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 1 GPPS(0.001)PPAPVMHS(0.029)PS(0.971)R 85.163 0.021002 9464300.0 17852.0 18917.0 35575.0 38737.0 44544.0 30756.0 18918.0 21413.0 32375.0 34152.0 True False 16859.857307218183 20367.87307225796 33286.14323113136 33460.95377494777 38947.984491587486 34992.35982482985 19797.724485305847 21475.308284887018 38850.90463308045 33165.94302244755 0.5083484976081338 0.6141201249267197 1.0036242059694325 1.0088949906324252 1.1743367123686639 1.0550690448073838 0.5969293401941337 0.6475108598706808 1.1714096175943247 1.0 15.017414926816771 -5.16594676823151 4.298462238165039 0.944719260794071 0.5343239724997596 0.42745712378721556 0.1840203676313527 0.23763854210727586 7.55166004576542 0.05215255537435427 0.15358512473854752 6.824223339828708e-06 5.16594676823151 -0.4103952882943114 GPQGS(ph)PLLSR ddPTM_A459_Selumetinib_30min_R2 2 GPQGSPLLSR 10 0 Q8TEP8-1;H0Y966;A0A0A0MR42;K7ENP4;Q8TEP8;K7EPA2 Q8TEP8-1 CEP192 Centrosomal protein of 192 kDa 1 GPQGS(1)PLLSR;GPQGS(1)PLLSR 110.15 0.0096348 35841000.0 43495.0 41166.0 43946.0 48987.0 57074.0 44525.0 38438.0 42191.0 42913.0 35879.0 True False 41077.72202428048 44323.29983044732 41118.56220478702 42314.88609271151 49903.853871966225 50657.91459229251 40225.44316345203 42313.76882490397 51496.79908940173 34843.080045162664 1.1789348694500212 1.272083288073174 1.1801069868533507 1.214441606134248 1.43224576608274 1.4538873867244537 1.1544743780203384 1.2144095404326483 1.4779634585304444 1.0 15.088584539923534 -6.075496903897407 24.995888030780613 1.3031092026198348 1.2133281234366355 0.06243072928046278 0.1405553855254311 336.79856425856127 111507.18678342745 0.04088866059100112 0.05278704909083351 8.404329985587757e-07 6.075496903897407 -0.08978107918319922 GPQPPTVS(ph)PIR ddPTM_A459_Selumetinib_30min_R1 1 GPQPPTVSPIR 11 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GPQPPTVS(1)PIR 167.73 0.00052008 393020000.0 2494.0 3545.6 3081.1 3677.8 3294.4 2677.1 2584.6 2172.9 1366.8 2054.1 True False 2552.1053475207746 3130.479503695278 2662.703543270842 3035.5412708563354 2996.4221016735614 2650.1708046123167 2389.6415411266025 2115.267633426076 2319.3597728776954 2317.763743628357 1.1011067692022682 1.350646506703332 1.1488244004984292 1.3096853720320645 1.2928073924319803 1.1434171459009843 1.031011701557521 0.9126329804929633 1.0006886073931072 1.0 11.178517800416799 -7.186106200783331 2.366987838332546 0.9693976464101044 1.2444802938439 0.7232854791684125 0.07430111658078244 0.14778265985884448 1.6207760626025833 0.032237688754586796 0.022469351877459395 6.514690667194091e-08 7.186106200783331 0.2750826474337955 GPQPPTVS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 4 GPQPPTVSPIR 11 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GPQPPT(0.004)VS(0.996)PIR;GPQPPTVS(1)PIR;GPQPPT(0.001)VS(0.999)PIR;GPQPPTVS(1)PIR 152.0 0.00058593 1548736000.0 1110960.0 928270.0 1053882.0 1115560.0 1115990.0 857949.0 999062.0 912303.0 735953.0 1130084.0 True False 1049217.290725246 999465.324141507 986076.3794999602 963618.8035516621 975789.3591228147 976123.6870644072 1045520.3626037955 914957.6506901073 883164.1642449262 1097455.5386091461 0.9560453738790781 0.910711449329577 0.898511461110906 0.8780481483312743 0.8891379420796178 0.8894425812470652 0.9526767379832349 0.8337081717676449 0.8047379899911017 1.0 20.065731062134994 -4.572973364515998 1.372699267916199 0.8879185858548904 1.0141282592259124 0.113361637115997 0.05174317159037348 4.323707491995825 5.115719903256109 0.014781988059108624 0.8681665437071934 2.6731703504256727e-05 4.572973364515998 0.12620967337102207 GPRIS(ph)APNVDFNLEGPK ddPTM_A459_Selumetinib_30min_R1 2 GPRISAPNVDFNLEGPK 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 GPRIS(1)APNVDFNLEGPK;GPRIS(1)APNVDFNLEGPK 144.95 0.00027086 68103000.0 7399.860000000001 4768.42 18901.5 18812.4 9968.0 9334.300000000001 5580.610000000001 5440.19 4239.97 3323.68 True False 7572.262340378935 4210.131169621686 16334.780118507611 15527.167492484008 9066.39615999334 9240.405416866291 5159.660094725112 5295.898488972435 7194.919414843609 3750.306703384791 2.019104819759058 1.122609829703231 4.3555851322146175 4.140239377880791 2.4175079205683576 2.463906594233075 1.3757968355143666 1.4121241028614246 1.9184882687994365 1.0 11.87279286996623 -7.077237474802041 2.293134462444321 1.4477602187588723 2.879664784916751 0.34215479141764804 0.9081071517570707 0.4089525862204824 4.245063124453717 0.44188067627338856 0.3307529926943563 8.370714413276535e-08 7.077237474802041 1.4319045661578789 GPS(ph)PAPASS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 1 GPSPAPASSPKR 12 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 2 GPS(1)PAPAS(0.004)S(0.996)PKR 104.81 0.041271 0.0 4432.2 5616.0 4617.4 4393.9 4031.8 4355.3 4557.1 4129.8 2877.2 4495.3 True False 4535.461636440085 4958.476109192433 3990.3824415626827 3626.5878487181594 3667.1244018721027 4311.489636296004 4213.354278057739 4020.264288519035 4882.39825762636 5072.31554293002 0.8941599941986612 0.977556712950112 0.7866983841580252 0.7149767828961333 0.7229685083341229 0.8500042238707955 0.8306569736045833 0.7925895489925951 0.9625580696436811 1.0 12.30842878133426 -8.353803690002357 4.426292809673805 0.9958631866015974 0.8197745627968016 0.43373889300408186 0.07347304076246991 0.2365377912760388 7.598827012290515 0.07871826572386433 0.02079914974316495 4.42788476590765e-09 8.353803690002357 -0.17608862380479584 GPS(ph)PAPASS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 GPSPAPASSPKR 12 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 2 GPS(0.999)PAPAS(0.009)S(0.991)PKR 103.13 0.03689 20662000.0 62974.0 56377.0 51661.0 56685.0 53981.0 48230.0 47684.0 52880.0 41823.0 60239.0 True False 59474.157184895696 60700.93461937344 48337.18750424389 48964.40521292083 47199.42418373706 54873.2447116512 49901.40048405347 53033.872045244745 50188.76863225707 58499.743550281615 1.0166567163457145 1.0376273627114256 0.8262803316855087 0.8370020489206934 0.8068313007760158 0.9380082951045183 0.8530191323174312 0.9065658894668683 0.8579314298894131 1.0 15.836142679808775 -5.2533666344025 24.944457346816368 0.8720836407674789 1.027142061448804 0.5376115664497516 0.05501621431226976 400.4054982830416 1237229.7357050013 0.013479043577337467 0.03436143799716787 5.5799892929029215e-06 5.2533666344025 0.15505842068132514 GPS(ph)PEGSSSTESSPEHPPK ddPTM_A459_Selumetinib_30min_R1 2 GPSPEGSSSTESSPEHPPK 19 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GPS(0.41)PEGS(0.138)S(0.138)S(0.138)T(0.172)ES(0.003)SPEHPPK;GPS(0.235)PEGS(0.235)S(0.235)S(0.235)T(0.059)ESSPEHPPK 111.93 0.00039264 12625100.0 6595.5 7551.0 6329.5 6602.6 9468.9 6984.9 9684.7 6445.9 1973.18 4799.700000000001 True False 6749.162317391041 6666.925409635339 5469.9886654548 5449.579856152052 8612.439666870072 6914.63824778177 8954.175281803296 6274.933792765955 3348.342344634774 5415.788248037106 1.246201293013478 1.2310166321683078 1.0100078538774735 1.0062394625800213 1.59024675124467 1.2767556505348792 1.6533466361149995 1.1586372113127275 0.6182557720657458 1.0 12.402955616728812 -8.08396147585492 6.172321011740413 0.8222567665872643 1.2839644475359533 0.43551639571725487 0.21464667452514455 0.2344548529437159 13.80902428399131 0.15453536417732075 0.05746735393685591 8.242112235276904e-09 8.08396147585492 0.46170768094868897 GPS(ph)PSPVGSPASVAQSR ddPTM_A459_Selumetinib_30min_R1 3 GPSPSPVGSPASVAQSR 17 0 O14497-2;O14497;H0Y488;A0A1B0GTU5;O14497-3;A0A087WUV6 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 GPS(0.99)PS(0.01)PVGSPASVAQSR;GPS(0.83)PS(0.169)PVGS(0.001)PASVAQSR;GPS(0.863)PS(0.136)PVGS(0.001)PASVAQSR 234.36 6.5431e-17 60263000.0 5150.370000000001 5884.96 5970.51 6648.5199999999995 6437.0 5725.25 6833.719999999999 7042.629999999999 3397.59 5225.83 True False 5270.363600124526 5195.946147356322 5159.747535663884 5487.480790177215 5854.77448654465 5667.659183111076 6318.246998540461 6855.836574713737 5765.462079844552 5896.616184394812 0.8937945824034398 0.8811742166816303 0.875035337948394 0.9306152238125385 0.992904117117052 0.9611714593380416 1.0715038593255366 1.1626730247183916 0.9777577341904405 1.0 12.525671575669268 -6.54047316724828 1.0846638325575853 1.061567388951245 0.8815568445671582 0.6327182605393218 0.05179334569564255 0.30077574503149906 0.754050266537004 0.02542335838778982 0.028732176232274687 2.8808910392481123e-07 6.54047316724828 -0.1800105443840867 GPS(ph)PSPVGSPASVAQSR ddPTM_A459_Selumetinib_30min_R2 3 GPSPSPVGSPASVAQSR 17 0 O14497-2;O14497;H0Y488;A0A1B0GTU5;O14497-3;A0A087WUV6 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 GPS(0.961)PS(0.039)PVGSPASVAQSR;GPS(0.906)PS(0.094)PVGSPASVAQSR;GPS(0.94)PS(0.06)PVGSPASVAQSR 227.41 3.1683e-16 128798900.0 115269.0 103982.0 140483.0 118801.0 126735.0 91976.0 89432.0 107144.0 87574.5 119323.0 True False 108862.81043836717 111957.0850451724 131444.4767263252 102620.09885684388 110813.41627472485 104644.85912500165 93590.76520614607 107455.77130135597 105091.8470359752 115877.83495161372 0.9394618952263324 0.9661647984010188 1.1343366639634882 0.8855886796615955 0.9562951907152598 0.9030619114405913 0.8076675340476123 0.9273194597243338 0.9069193179166459 1.0 16.822245109258304 -5.856524590639535 21.748715269865542 0.9064503495648584 1.0089712772523147 0.32258888544151143 0.06652833697152356 6.729264085662376 1530.302998710746 0.018745079471355515 0.0278034935690847 1.391475004460667e-06 5.856524590639535 0.10252092768745635 GPS(ph)WDPFR ddPTM_A459_Selumetinib_30min_R1 1 GPSWDPFR 8 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 GPS(1)WDPFR 122.94 0.0061569 28202000.0 6893.6 9426.5 5368.9 6284.6 6500.4 7102.4 5484.2 7390.8 3619.9 5950.7 True False 7054.2074673894185 8322.840997739047 4639.832869256697 5187.112586552751 5912.439967738832 7030.9563044632305 5070.52237864525 7194.771975298194 6142.705912964566 6714.530309726527 1.0505883720817883 1.2395269086331706 0.6910137649591861 0.7725205408692264 0.8805440879720501 1.0471255590697588 0.7551566743693446 1.0715227489368837 0.9148377666962605 1.0 12.71307076941861 -5.246272226860781 24.999551583763548 0.8901797454928105 1.1450576503290677 0.39131358466526966 0.12643953601903943 825.0726757438633 1359936.8965861942 0.032446562500452844 0.08513375173249571 5.671889654446818e-06 5.246272226860781 0.25487790483625716 GPS(ph)WDPFR ddPTM_A459_Selumetinib_30min_R2 4 GPSWDPFR 8 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 GPS(1)WDPFR;GPS(1)WDPFR;GPS(1)WDPFR;GPS(1)WDPFR 117.53 0.0088168 31750800.0 401905.0 210156.0 305495.0 383196.0 475204.0 265293.0 426302.0 532766.0 352675.0 228663.0 True False 379568.7290531887 226274.28944195458 285839.78429780685 331004.04375002923 415504.6251423384 301834.70265992254 446125.88770138775 534316.2608558411 423219.85456283065 222060.90505217615 1.7093001082923804 1.018974003500474 1.287213452681574 1.4906002642484748 1.871129116783119 1.359242873431514 2.0090249006080767 2.4061698781705694 1.9058728706135353 1.0 17.76059589590345 -6.366448607062865 1.154527960403917 1.8826841677633162 1.304573149145075 0.15299301697201917 0.397051123102093 0.6815783633183327 1.8917906478452362 0.17258758378235378 0.22945578306090303 4.3008212508042867e-07 6.366448607062865 -0.5781110186182412 GPSAGGGPGS(ph)GTSPQVEWTAR ddPTM_A459_Selumetinib_30min_R1 1 GPSAGGGPGSGTSPQVEWTAR 21 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-4;Q7Z406-5;A0A2R8Y454;A0A2R8Y4C3;M0QY43 Q7Z406 MYH14 Myosin-14 1 GPSAGGGPGS(0.545)GT(0.228)S(0.228)PQVEWTAR 187.5 1.368e-16 9871800.0 1165.8 1276.9 1540.2 1406.7 1358.6 1217.8 1260.4 1313.2 721.52 1253.8 True False 1192.9608717480833 1127.3999543852956 1331.049299713008 1161.0462520293663 1235.714869880312 1205.5500376739303 1165.3270132461387 1278.369670125234 1224.3667422642054 1414.737443046217 0.8432383532448227 0.7968969506863227 0.9408454595270968 0.8206796658533317 0.8734588003973139 0.8521369414512252 0.8237055002495395 0.9036091300253173 0.8654374338378259 1.0 10.466318617039228 -14.522878744591527 0.2486730429718247 1.862403984736911 0.8451210717163923 0.5537501317798703 0.038949829153987814 133.236130006077 1.3197328213004011 58.275665134595414 0.054876735056198674 3.0000000047581375e-15 14.522878744591527 -1.0172829130205185 GPSAGGGPGSGT(ph)SPQVEWTAR ddPTM_A459_Selumetinib_30min_R1 1 GPSAGGGPGSGTSPQVEWTAR 21 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-4;Q7Z406-5;A0A2R8Y454;A0A2R8Y4C3;M0QY43 Q7Z406 MYH14 Myosin-14 1 GPSAGGGPGS(0.02)GT(0.49)S(0.49)PQVEWTAR 181.86 4.5042e-14 8719300.0 1685.2 1969.4 2407.1 2052.0 2038.8 1567.2 1765.9 1958.8 1047.5 1409.4 True False 1724.4618811716146 1738.8217324507793 2080.2290412538514 1693.6567208105917 1854.3908999793753 1551.4353909037477 1632.696741265754 1906.8462609208884 1777.5309936270014 1590.3102187185666 1.0843556564461645 1.0933852477234787 1.3080649402668427 1.064985121063549 1.1660560802241455 0.975555192089413 1.0266529901199664 1.199040437819345 1.1177259459851128 1.0 10.63509250133686 GPSAGGGPGSGT(ph)SPQVEWTAR ddPTM_A459_Selumetinib_30min_R2 2 GPSAGGGPGSGTSPQVEWTAR 21 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-4;Q7Z406-5;A0A2R8Y454;A0A2R8Y4C3;M0QY43 Q7Z406 MYH14 Myosin-14 1 GPSAGGGPGS(0.298)GT(0.351)S(0.351)PQVEWTAR;GPSAGGGPGS(0.02)GT(0.948)S(0.032)PQVEWTAR 291.99 1.8720999999999996e-86 11361800.0 33912.0 31191.0 38456.0 44091.0 47063.0 33261.0 37131.0 39767.0 31333.0 35033.0 True False 32027.306800492006 33583.24940512757 35981.78282772697 38085.729738782604 41150.52519144176 37842.40083670393 38857.665073680655 39882.71538621878 37600.47551716785 34021.50626333467 0.9413841513245452 0.9871182405971423 1.0576187470719047 1.1194604214166728 1.2095444826259827 1.1123082130401463 1.1421500498218082 1.1722795304098805 1.1051972604073168 1.0 15.054159395640024 -5.3877130525067365 1.8023669189058371 1.1346700545633182 0.9471435350640537 0.5950316027170452 0.052056796525483486 0.24158033040344523 1.4440281078342758 0.014475447124024748 0.05008001677463594 4.095311562022541e-06 5.3877130525067365 -0.18752651949926447 GPSLNPVLDYDHGS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GPSLNPVLDYDHGSR 15 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 GPSLNPVLDYDHGS(1)R 83.06299999999997 0.016006 4883500.0 2611.1 4790.3 2405.8 2377.4 2766.9 2616.8 4154.2 3409.0 1633.9 2749.7 True False 2671.9335496838394 4229.449449049948 2079.105574113463 1962.2317193250979 2516.63438353587 2590.477367864299 3840.845349434393 3318.5822460074073 2772.608964665545 3102.6507793461337 0.8611776637804318 1.3631728962875032 0.6701062162566754 0.632437183194245 0.8111239589994194 0.8349239254087847 1.2379238343555472 1.0695958011448456 0.8936258579671209 1.0 11.599285607291446 -7.223434086193123 24.84749234039013 1.056086136878981 0.8634393210620388 0.17248928745727155 0.20169654258753875 997.5597509070601 652195.388153135 0.08266216310167641 0.0640284179360767 5.9781376928434e-08 7.223434086193123 -0.1926468158169421 GPSLNPVLDYDHGS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GPSLNPVLDYDHGSR 15 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 GPSLNPVLDYDHGS(1)R 79.695 0.020236 3421100.0 18203.0 13283.0 19702.0 26471.0 31069.0 27961.0 21180.0 27419.0 39913.0 18970.0 True False 17191.350132382515 14301.763388423245 18434.394769915667 22865.60413497797 27165.83445961592 31812.373945313648 22164.911967373802 27498.784750540195 47896.71526239814 18422.286810020792 0.9331821998901509 0.7763294283662878 1.0006572452171512 1.2411924953062958 1.47461793097473 1.7268417473562145 1.2031574687740292 1.4926911644640255 2.599933208962133 1.0 14.169164537867971 -5.991564536361957 1.24177521648871 1.6255237855838853 0.8284078701182963 0.37807609714521806 0.3959434642310319 0.49525907124794527 1.5517231055106915 0.14669907446713057 0.2822038602968187 1.0196132337859007e-06 5.991564536361957 -0.797115915465589 GPSPAAAS(ph)PEGSPLR ddPTM_A459_Selumetinib_30min_R2 2 GPSPAAASPEGSPLR 15 0 Q9P107;Q9P107-2 Q9P107 GMIP GEM-interacting protein 1 GPSPAAAS(0.999)PEGSPLR;GPS(0.001)PAAAS(0.989)PEGS(0.01)PLR 121.13 0.0017115 4285200.0 15101.0 17351.5 18330.1 20412.7 18766.0 12079.6 11485.4 13931.8 15116.9 14761.7 True False 14261.746874092645 18682.304256133848 17150.761322303886 17632.455046128405 16408.447309831412 13743.455252308959 12019.493857888343 13972.339231466352 18140.702401476858 14335.491365497302 0.9948558099946162 1.3032203626517098 1.1963846152900195 1.2299860951098087 1.144603061833186 0.9587013728309824 0.8384431026073436 0.9746676186555429 1.2654398749901206 1.0 13.807303735011532 -6.649916655058472 4.809766457807456 0.9958811478064277 1.1902827094381112 0.3114764775178078 0.12338466689527268 0.24660842315728054 9.355621811209975 0.04236287175727394 0.04210051428658112 2.2391508101277787e-07 6.649916655058472 0.19440156163168354 GPSPAPAS(ph)S(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 GPSPAPASSPKR 12 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 2 GPS(0.457)PAPAS(0.548)S(0.995)PKR 107.09 0.029 18200000.0 51141.0 54098.0 56307.0 60560.0 61124.0 41400.0 49343.0 48032.0 37257.0 56100.0 True False 48298.787953643594 58247.14264751345 52684.26892242619 52311.623528172975 53445.056664506854 47102.474208218075 51637.54727129962 48171.76516787437 44709.441047557586 54480.247234695096 0.8865376059249064 1.069142406725707 0.967034321549019 0.960194312313233 0.9809987908878469 0.8645789363859829 0.947821456258276 0.884206067574465 0.8206541511266291 1.0 15.73344562995265 -6.746941765322688 24.723036534879284 0.8989880868412728 0.9771163202026684 0.24115380193049407 0.06099441877776391 268.2929058189578 457523.47793605353 0.019324649084099643 0.019238735961401802 1.790845973009669e-07 6.746941765322688 0.07812823336139552 GPSPAPAS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 GPSPAPASSPK 11 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 GPSPAPAS(0.724)S(0.276)PK 145.09 0.00070803 23693000.0 8581.7 9707.7 9380.3 9793.5 7184.0 7756.5 8295.1 8492.7 5887.0 8622.8 True False 8781.636912918617 8571.117971012714 8106.506782299656 8083.249071763422 6534.208468438213 7678.476652338517 7669.39392857668 8267.446007822553 9989.80903053189 9729.620373184656 0.9025672714961489 0.8809303592805291 0.8331781170662746 0.8307877143944157 0.6715789740827744 0.7891856370368572 0.7882521243803028 0.8497192789359046 1.026741912568791 1.0 13.248167800212313 -8.188903695989904 3.985588320325708 1.0153403373459577 0.8118903723194855 0.6358993230258088 0.05940518410958691 0.1529633354503829 4.507706411052449 0.051894518299259416 0.017084341416686927 6.472861343564663e-09 8.188903695989904 -0.20344996502647228 GPSPAPASS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 GPSPAPASSPK 11 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 GPSPAPAS(0.023)S(0.977)PK 160.56 0.00060085 27334000.0 10140.0 12412.0 11723.0 11790.0 9741.2 9929.0 9974.3 10810.0 7367.3 10613.0 True False 10376.242270994646 10958.797269817747 10131.080989829623 9731.097825709989 8860.110179948548 9829.123274810698 9221.930520644995 10523.28368417133 12501.770013697582 11975.281929374303 0.8664716481991664 0.9151181019744338 0.8459993718376668 0.8125986413597888 0.7398665210725005 0.8207842899047522 0.7700804519703556 0.8787503915343029 1.0439645669662148 1.0 13.547772000715273 -8.137067265420134 3.96682915563313 1.020838631267239 0.8248181733961708 0.7313519572173968 0.04707696080998778 0.1315993936569465 3.427961646010417 0.0400784998587996 0.013686640041197733 7.293445374486459e-09 8.137067265420134 -0.19602045787106825 GPSPAPASS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 GPSPAPASSPK 11 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 GPSPAPAS(0.33)S(0.67)PK;GPSPAPAS(0.229)S(0.771)PK;GPSPAPAS(0.015)S(0.985)PK 135.1 0.0015257 38161400.0 381134.0 343625.0 335125.0 330988.0 287732.0 219419.0 302390.0 311451.0 225903.0 285393.0 True False 359952.0980802878 369979.9325714785 313563.42235651094 285906.86341385316 251584.53380328324 249641.97556263322 316451.73417441786 312357.27084651135 271089.91225719766 277152.9625499354 1.2987488741544095 1.3349304628299552 1.1313731575213286 1.0315850885495788 0.907746146707541 0.9007371715092332 1.1417945212019946 1.1270212231277632 0.9781238120749104 1.0 18.080322903433725 -5.457820237913772 2.576649606842396 1.0141137381802883 1.3208391057873077 0.7207743714714305 0.07513347473365901 0.16582849772898353 2.1384205610928477 0.023699976908677 0.05815901122857701 3.4848152779065246e-06 5.457820237913772 0.3067253676070194 GPSPAPASS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 2 GPSPAPASSPKR 12 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 GPSPAPAS(0.166)S(0.834)PKR;GPSPAPAS(0.018)S(0.982)PKR 103.46 0.0056335000000000005 15799800.0 5159.2 7060.5 5325.0 6828.0 5901.2 5698.4 5801.2 5817.6 3526.2999999999997 4724.4 True False 5279.399321944338 6233.853377662602 4601.89424813126 5635.617977434075 5367.43750194148 5641.079269733232 5363.610813427085 5663.298349771978 5983.8735492380865 5330.822759552995 0.990353564556896 1.1693979820453322 0.8632615368583633 1.0571760179673724 1.00686849742338 1.0582004925270208 1.0061506554153077 1.0623685320663074 1.1225046900152147 1.0 12.380142500483704 -7.867346660243145 6.255949721401789 1.0710314933466296 1.0235338135614365 0.050550853313615196 0.0766102817514401 0.6159650270056719 31.770223827701628 0.04058925293260059 0.019255195868575586 1.35722965342311e-08 7.867346660243145 -0.04749767978519315 GPSPPLNGNILS(ph)CSPDRR ddPTM_A459_Selumetinib_30min_R2 1 GPSPPLNGNILSCSPDRR 18 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GPSPPLNGNILS(0.573)CS(0.427)PDRR 67.605 0.014975 4302800.0 12782.0 12442.0 9586.8 12700.0 11756.0 8645.1 10020.0 7086.9 8527.8 10677.0 True False 12071.62761040011 13396.261392664468 8969.995725318624 10970.238091278019 10279.106180026542 9835.884052595806 10485.949854253337 7107.521705700546 10233.598286640414 10368.727267822454 1.1642342689311842 1.2919870536316873 0.8651009418634675 1.0580120209470885 0.9913565970556448 0.9486105477110739 1.0113053977988853 0.6854767728106328 0.9869676405125063 1.0 13.339951197800074 -4.922486053194562 0.6682794444590527 0.9121249365551194 1.4038474476045901 0.3956812939185773 0.11935486538562513 2.625073259032732 1.0064288887193855 0.05449812351742164 0.9569560726775276 1.19540191384329e-05 4.922486053194562 0.49172251104947073 GPSPS(ph)PVGSPASVAQSR ddPTM_A459_Selumetinib_30min_R1 1 GPSPSPVGSPASVAQSR 17 0 O14497-2;O14497;H0Y488;A0A1B0GTU5;O14497-3;A0A087WUV6 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 GPS(0.177)PS(0.814)PVGS(0.009)PASVAQSR 135.69 0.00051588 19430000.0 1166.7 1424.6 1282.5 1243.6 1653.7 1012.9 1559.1 1415.6 655.45 913.69 True False 1193.8818399969878 1257.8071697214282 1108.3435442682337 1026.4286052631835 1504.1231269844475 1002.7111456396166 1441.4958317613878 1378.0536894831569 1112.2507778260797 1030.9710115942719 1.158016885606506 1.2200218585936589 1.0750482135810149 0.9955940503855059 1.4589383310191264 0.9725890780275628 1.3981923987681175 1.3366560979752122 1.0788380714081558 1.0 10.009788052850999 GPSQEEEDNHS(ph)DEEDR ddPTM_A459_Selumetinib_30min_R1 2 GPSQEEEDNHSDEEDR 16 0 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPSQEEEDNHS(1)DEEDR;GPSQEEEDNHS(1)DEEDR 174.15 2.2367e-06 4116300.0 881.0699999999999 999.53 438.41 657.19 747.88 546.8199999999999 696.69 815.24 468.53 1014.0500000000001 True False 901.5972167362185 882.5045629311093 378.87633001375127 542.4241034841684 680.2343860489382 541.3194872728351 644.1381123916628 793.6171869272739 795.0611899227293 1144.2131951834551 0.7879626109290434 0.7712763378765394 0.33112389509981566 0.4740585983167236 0.594499686695078 0.47309320461563437 0.562952878976707 0.6935920598259059 0.694854065019985 1.0 10.160140171549074 -8.706834862511702 1.0566519842546789 0.9974381504029557 0.5643708645371996 0.4840269190647878 0.13115558945584893 0.7040234727851794 1.582615374536371 0.13476784295096306 0.04322014885189853 1.964106973025184e-09 8.706834862511702 -0.43306728586575605 GPSQEEEDNHS(ph)DEEDR ddPTM_A459_Selumetinib_30min_R2 2 GPSQEEEDNHSDEEDR 16 0 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPSQEEEDNHS(1)DEEDR;GPSQEEEDNHS(1)DEEDR 90.442 0.0081786 9715500.0 3836.1 2139.68 4851.4 4259.1 5757.1 4256.2 5647.1 4957.8 6052.6 3680.0099999999998 True False 3622.9049191250097 2303.7865758444227 4539.2662058049345 3679.003232642694 5033.841628872984 4842.452916063233 5909.701339516365 4972.226377192028 7263.289123773985 3573.7585494857462 1.0137520117710066 0.6446396822683869 1.2701658892031533 1.029449298742382 1.4085567223329454 1.3550028209824214 1.653637552085536 1.3913156997994498 2.0323950326244486 1.0 11.80322645087514 -6.061736685846481 0.8820063823520964 1.5493197421821383 0.8367469810803231 0.4313227622400644 0.27770080179742995 0.5612565876087074 0.8960584032901423 0.12329251205843736 0.2609225673206605 8.674876769378656e-07 6.061736685846481 -0.7125727611018152 GPSQEEEDNHS(ph)DEEDRASEPK ddPTM_A459_Selumetinib_30min_R1 4 GPSQEEEDNHSDEEDRASEPK 21 1 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPSQEEEDNHS(1)DEEDRASEPK;GPSQEEEDNHS(1)DEEDRASEPK;GPSQEEEDNHS(0.999)DEEDRASEPK;GPSQEEEDNHS(1)DEEDRASEPK 108.14 5.4132e-05 122184400.0 11448.199999999999 13194.4 14302.0 14491.1 13268.8 11832.1 12024.7 11585.2 7748.000000000001 10815.5 True False 11714.920785680566 11649.593514089858 12359.866955262583 11960.50141663663 12068.639382796913 11713.079816687234 11117.667197858489 11277.922861966857 13147.790108469708 12203.77477689133 0.9599423948615929 0.9545893567414198 1.0127904833729662 0.9800657284567924 0.9889267545030161 0.9597915424387166 0.911002325191263 0.9241339723281655 1.0773543718101004 1.0 13.5750398395983 -8.261386925610982 24.999984607899485 1.0386771851873866 0.9626964622458734 0.47060229074778315 0.03275985572209319 4.402243714914708 2101415.9202082935 0.027736295309407483 0.0088485126012692 5.477887065279652e-09 8.261386925610982 -0.07598072294151326 GPSQEEEDNHS(ph)DEEDRASEPK ddPTM_A459_Selumetinib_30min_R2 3 GPSQEEEDNHSDEEDRASEPK 21 1 E7ERS3;Q86VM9;H3BPD0 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPSQEEEDNHS(0.999)DEEDRAS(0.001)EPK;GPS(0.001)QEEEDNHS(0.99)DEEDRAS(0.009)EPK;GPSQEEEDNHS(1)DEEDRASEPK 89.344 0.0003495 44281200.0 103231.0 104012.0 123652.0 120724.0 121943.0 83244.0 86975.0 92191.0 75369.0 110856.0 True False 97493.83428643516 111989.3859487072 115696.36494211797 104281.18293948425 106623.4301557483 94710.10538620541 91019.50983769301 92459.26054695829 90444.90598581123 107655.29924152148 0.9056111029677287 1.0402589258282802 1.0746927067896268 0.9686581494286918 0.9904150646271651 0.8797533057218678 0.8454717090469781 0.8588454186498398 0.8401342676397263 1.0 16.716059811139324 -6.747740470828267 4.218717813574974 0.8722835794090882 1.0029339116234623 0.45861975926570786 0.059531618616846506 0.16727614062167614 6.830167277027459 0.020490554551949387 0.01937033049461304 1.7875554774436637e-07 6.747740470828267 0.13065033221437417 GPSS(ph)PPTTTAPMR ddPTM_A459_Selumetinib_30min_R1 2 GPSSPPTTTAPMR 13 0 Q9NXL9-4;Q9NXL9 Q9NXL9-4 MCM9 DNA helicase MCM9 1 GPS(0.016)S(0.979)PPTT(0.003)T(0.002)APMR;GPS(0.051)S(0.88)PPT(0.001)T(0.034)T(0.034)APMR 126.5 0.0020216 28498000.0 7763.9 8923.400000000001 9692.5 10213.6 9958.8 8202.3 8679.8 8858.0 4869.4 6828.6 True False 7944.783764080407 7878.6441796238905 8376.3117370915 8429.986493017092 9058.028298368943 8119.792309092533 8025.0756978529325 8623.057065160927 8263.016153095296 7705.11732619668 1.0311048395160556 1.0225209878164003 1.0871102129247043 1.0940763308503978 1.1755860313213522 1.0538181270109928 1.0415254379798247 1.1191337782545294 1.0724062727769001 1.0 12.911601209557034 -5.263540009270883 23.90994183756054 1.0862538695898367 1.026812907594086 0.1793018936797408 0.0445469249884592 143.1041694574252 1628893.01764882 0.0115019746434838 0.02610733397835411 5.4507967804634195e-06 5.263540009270883 -0.059440961995750774 GPSS(ph)PPTTTAPMR ddPTM_A459_Selumetinib_30min_R2 2 GPSSPPTTTAPMR 13 0 Q9NXL9-4;Q9NXL9 Q9NXL9-4 MCM9 DNA helicase MCM9 1 GPS(0.032)S(0.612)PPT(0.007)T(0.205)T(0.145)APMR;GPS(0.205)S(0.762)PPT(0.012)T(0.012)T(0.009)APMR 109.16 0.00603 16961900.0 46232.0 45551.0 49767.0 56630.0 56222.0 39125.0 44827.0 41979.0 34761.0 44652.0 True False 43662.610521359595 49044.615230450014 46565.04540221259 48916.89630780113 49158.889728942835 44514.113608611886 46911.54432301538 42101.15194000242 41714.17130349062 43362.78074017126 1.0069144500438039 1.1310302151590361 1.0738482313029973 1.1280848569401025 1.1336655281288743 1.0265511770414213 1.0818389301209308 0.9709052607182068 0.9619810028660507 1.0 15.404169655416062 -7.753257019303985 8.346014687210815 0.9746331123356099 1.0862277969928815 0.5801525698618012 0.04104847608108773 0.08575657999597013 46.73633018560331 0.020366805153342923 0.011002288982913437 1.7649929731365116e-08 7.753257019303985 0.11159468465727163 GPSS(ph)VEDIK ddPTM_A459_Selumetinib_30min_R1 7 GPSSVEDIK 9 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 GPS(0.018)S(0.982)VEDIK;GPS(0.004)S(0.996)VEDIK;GPS(0.002)S(0.998)VEDIK;GPS(0.363)S(0.637)VEDIK;GPS(0.01)S(0.99)VEDIK;GPS(0.156)S(0.844)VEDIK;GPS(0.078)S(0.922)VEDIK 150.15 0.0013502 262267900.0 33822.5 40607.50000000001 42198.899999999994 45163.299999999996 39336.200000000004 35735.700000000004 41714.399999999994 46671.100000000006 20637.1 32880.6 True False 34610.49844287143 35853.155022085426 36468.521161965495 37276.377475138914 35778.247655370185 35376.23130341954 38567.849223543875 45433.23081890178 35019.651425851815 37101.145294166105 0.9328687340634115 0.9663624865974982 0.9829486629810297 1.004723093575237 0.9643434824368095 0.9535077966712312 1.0395325782465372 1.2245775826776386 0.9438967759132333 1.0 15.179176102371553 -7.411014126283695 5.1353434970961045 1.0752305688732477 0.9702854438586438 0.24768799122159335 0.06966641929119935 0.2609074975373448 10.071424489554735 0.02857677728571946 0.018829259939024682 3.881377408405688e-08 7.411014126283695 -0.10494512501460396 GPSS(ph)VEDIK ddPTM_A459_Selumetinib_30min_R2 5 GPSSVEDIK 9 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 GPS(0.025)S(0.975)VEDIK;GPS(0.011)S(0.989)VEDIK;GPS(0.288)S(0.712)VEDIK;GPS(0.008)S(0.992)VEDIK;GPS(0.367)S(0.633)VEDIK 147.28 0.0016555999999999995 220788700.0 637766.0 653197.0 645862.0 621178.0 646012.0 464111.0 534335.0 512677.0 408215.0 555702.0 True False 602321.5188995802 703295.1095406075 604307.9420813754 536572.4848081812 564854.1971394441 528038.0774698136 559182.6362647158 514168.80519175366 489869.40648009046 539657.4393728077 1.1161182538308023 1.303225079891385 1.1197991503345248 0.9942834947884497 1.0466902815162153 0.9784690044920011 1.0361807240433865 0.9527688635022301 0.9077414128663154 1.0 19.041684386637137 -5.614706245502593 3.3084192998497852 0.9894699771856562 1.2115933007472293 0.7193225085764108 0.05651168934236816 0.11730219077975229 2.533922895844701 0.015548882648941238 0.029731981769582652 2.4282519965787137e-06 5.614706245502593 0.22212332356157305 GPSS(ph)VEDIKAK ddPTM_A459_Selumetinib_30min_R1 2 GPSSVEDIKAK 11 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 GPS(0.398)S(0.602)VEDIKAK;GPS(0.055)S(0.945)VEDIKAK 113.95 0.028602 8147600.0 2353.4 1507.8 9042.2 8968.3 4562.7 3547.3999999999996 2871.0 3003.2 2429.09 2199.19 True False 2408.22964108075 1331.2660750427972 7814.318905249293 7402.154760840949 4150.00459061011 3511.716376781495 2654.4381585446386 2923.5453802315756 4121.988316285835 2481.477458424637 0.9704821750061802 0.5364812283597973 3.1490589925447896 2.9829627247713137 1.6723926209850546 1.4151715804869345 1.0697006936463591 1.1781470632772078 1.6611024622817547 1.0 11.276983634011327 -6.718884178764005 3.617965051121681 1.2530033592300678 1.9395111620598378 0.13771670611269915 0.7594362921659444 0.5175338534169766 14.0232691990192 0.29923067053455427 0.28684199246759323 1.9103626619152262e-07 6.718884178764005 0.68650780282977 GPSWDPFRDWYPHSR ddPTM_A459_Selumetinib_30min_R1 1 GPSWDPFRDWYPHSR 15 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 81.619 0.021456 7318100.0 5886.2 2836.8 8068.1 11392.0 5234.4 5620.8 2950.2 3934.9 3275.5 2184.3 False True 6023.33700744859 2504.6661372074586 6972.496334901003 9402.601054324698 4760.94944420838 5564.259855278065 2727.6640387803536 3830.5336696434565 5558.284266945339 2464.6761818837545 2.4438654666776336 1.0162252370585818 2.8289705504322753 3.814943773724579 1.9316734097578616 2.257602802419787 1.1067028029197723 1.5541732004387594 2.255178310157214 1.0 11.267182397196953 -7.113857119627841 5.014732339925181 1.5277493881433515 2.4029941430772186 0.2693832194650143 0.729033945149766 0.3663813332897897 13.692095562422894 0.30162680704226175 0.23291500375052912 7.693835213808804e-08 7.113857119627841 0.8752447549338671 GPT(ph)PGQAPAGGAGAEGK ddPTM_A459_Selumetinib_30min_R1 1 GPTPGQAPAGGAGAEGK 17 0 H7BY14;A0A087WYU3;Q96NU1-6;Q96NU1;H7C3J6;A0A087X1J5;Q96NU1-1;Q96NU1-2;A0A087WXB3;A0A087X223;A0A087WYW1;Q96NU1-4;Q96NU1-5 H7BY14;A0A087WXB3 SAMD11 Sterile alpha motif domain-containing protein 11 1 GPT(1)PGQAPAGGAGAEGK 114.56 0.003968 0.0 894.57 1048.5 1080.0 1208.2 1227.8 1060.2 1107.6 1034.9 513.34 993.89 True False 915.4117404697906 925.7411325655738 933.3419320153548 997.2105507228844 1116.7457067856956 1049.5353505845799 1024.0528402661243 1007.4510901710364 871.1004871298189 1121.4654628084263 0.8162638715394531 0.8254744914277516 0.8322520514167563 0.8892030863131737 0.9957914388099735 0.935860608632819 0.9131380985212361 0.8983344771475443 0.7767519518152332 1.0 10.131169475837726 -5.824201001103173 3.765541493346168 0.9172298142103708 0.8233855178902502 0.3485779494437987 0.058051342980880945 0.2678149742116677 7.59913611598147 0.017179842316739666 0.027572399096929094 1.4989909087464408e-06 5.824201001103173 -0.09384429632012059 GPTS(ph)SPCEEEGDEGEEDR ddPTM_A459_Selumetinib_30min_R2 1 GPTSSPCEEEGDEGEEDR 18 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPTS(0.906)S(0.093)PCEEEGDEGEEDR 216.0 3.8054000000000005e-14 4496100.0 4178.4 3291.8 3788.3 5403.4 5854.1 3514.1 4896.2 5377.0 5102.1 2916.8 True False 3946.181255460479 3544.2704751947363 3544.5649023891738 4667.447598615091 5118.655621681981 3998.135377176309 5123.883001636243 5392.64617978973 6122.662564585008 2832.584405243472 1.3931380996646026 1.251249731034967 1.2513536739903446 1.6477699975947957 1.8070619933537382 1.411479696695094 1.8089074387867445 1.903790111181598 2.1615110756280327 1.0 11.467903230720905 -5.825783787914755 4.898484785269724 1.7198511413960191 1.293207156046659 0.2504735935690875 0.29545670463570556 0.24984460961389798 11.635457717818701 0.08208965207145019 0.1268208735143139 1.4935377774122892e-06 5.825783787914755 -0.4266439853493602 GPTS(ph)SPCEEEGDEGEEDRTSDLR ddPTM_A459_Selumetinib_30min_R2 1 GPTSSPCEEEGDEGEEDRTSDLR 23 1 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPT(0.142)S(0.478)S(0.38)PCEEEGDEGEEDRTSDLR 96.045 4.0818e-05 34243000.0 18000.0 16217.0 21137.0 26538.0 22314.0 19649.0 20690.0 24709.0 18154.0 13982.0 True False 16999.63205970912 17460.79175412631 19777.068432225533 22923.47861939655 19510.71583030898 22355.471394137134 21652.12599645723 24780.899099204835 21785.307265141073 13578.3033304012 1.2519702680118894 1.2859332516922342 1.456519857524878 1.688243226093788 1.4369038130578051 1.646411252581481 1.594612041695895 1.8250364936038463 1.6044204297870386 1.0 13.729015599210138 -5.391172185106867 2.972792884646026 1.578962940064093 1.2623101034743545 0.19536641251311704 0.20867528342430736 0.3413521827605122 5.686211824593608 0.053727663733691235 0.13293282514859148 4.062822181688507e-06 5.391172185106867 -0.31665283658973853 GPTSS(ph)PCEEEGDEGEEDR ddPTM_A459_Selumetinib_30min_R1 2 GPTSSPCEEEGDEGEEDR 18 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPTS(0.03)S(0.969)PCEEEGDEGEEDR;GPT(0.001)S(0.126)S(0.873)PCEEEGDEGEEDR 197.73 2.3219e-10 5238600.0 1432.54 1659.74 1116.78 1254.9 1337.5 1359.73 1712.31 1646.19 787.13 1635.9 True False 1465.9153947623934 1465.4168692078076 965.1274100334322 1035.7552723904541 1216.5233611548042 1346.0523507360604 1583.1490781113098 1602.5276936212767 1335.7021202994008 1845.8837000153978 0.7941537133407511 0.7938836391456209 0.5228538558660989 0.5611162135414134 0.6590465916919123 0.7292183958961401 0.8576645853138546 0.8681628715871477 0.7236112005801117 1.0 10.850095943443936 -7.09185113977038 2.8615952309751105 0.8522420289435223 0.6602637455457412 0.4514340430516235 0.10171324034978996 0.2867022153774325 4.557144186601226 0.04521229102454084 0.034381556919251745 8.09373275130185e-08 7.09185113977038 -0.1919782833977811 GPTSS(ph)PCEEEGDEGEEDR ddPTM_A459_Selumetinib_30min_R2 1 GPTSSPCEEEGDEGEEDR 18 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPTS(0.015)S(0.985)PCEEEGDEGEEDR 258.14 1.7523e-42 5835500.0 8084.5 5136.9 6698.1 7102.1 10289.0 7965.2 9456.4 9230.8 9460.5 6946.5 True False 7635.195854817692 5530.883712263146 6267.151538339872 6134.781728194143 8996.403835172938 9062.333999113496 9896.14133750112 9257.660099758798 11352.86434845583 6745.936495825484 1.131821483872921 0.8198837501191664 0.9290261688970993 0.9094040141039669 1.3336033982442745 1.3433767134809889 1.4669781347074708 1.3723313442822382 1.6829189476481439 1.0 12.719803021993982 -6.316251768236356 4.180322704929612 1.395760182548747 0.935228463110969 0.580855663757559 0.17366994800721938 0.14448074853527015 5.289910492423867 0.0521845206615428 0.06100881437514315 4.827788454153758e-07 6.316251768236356 -0.46053171943777793 GPTSSPCEEEGDEGEEDRTSDLRDEAS(ph)SVTR ddPTM_A459_Selumetinib_30min_R1 1 GPTSSPCEEEGDEGEEDRTSDLRDEASSVTR 31 2 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 GPTSSPCEEEGDEGEEDRT(0.113)S(0.113)DLRDEAS(0.38)S(0.38)VT(0.014)R 45.745 0.011353 10087000.0 626.14 608.57 945.08 864.39 1004.1 639.32 678.1 732.09 407.82 655.34 True False 640.7278437436477 537.3183414834829 816.743326952844 713.4405131098772 913.279332288253 632.8890212561158 626.9503710585576 712.6725950365386 692.0407540056934 739.4592725521677 0.8664815866494463 0.7266368296782375 1.1045142812719602 0.9648138032639858 1.2350637366898698 0.8558808371849398 0.8478497658088766 0.9637753173029021 0.9358740632424364 1.0 9.530326879485703 -5.252169521097348 24.996054411183636 0.9853821038352468 0.7965592031774238 0.31914749849038715 0.11205001186897358 821.3993576408095 2214881.016504109 0.029620116299964996 0.076118990544583 5.595391501687668e-06 5.252169521097348 -0.18882290065782303 GPTSTSIDNIDGT(ph)PVRDER ddPTM_A459_Selumetinib_30min_R1 4 GPTSTSIDNIDGTPVRDER 19 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 GPTSTSIDNIDGT(1)PVRDER;GPTSTSIDNIDGT(1)PVRDER;GPTSTSIDNIDGT(1)PVRDER;GPTSTSIDNIDGT(1)PVRDER 290.92 1.8617999999999997e-84 118347000.0 9499.199999999999 11912.6 12363.099999999999 13481.0 12766.099999999999 10426.599999999999 11215.7 9545.3 6238.000000000001 9246.099999999999 True False 9720.51287777439 10517.867253982504 10684.258925647251 11126.796419711309 11611.408509038018 10321.717870595337 10369.690719188133 9292.127636495883 10585.430394506191 10432.926999640787 0.9317148368918017 1.0081415555140605 1.0240902601940105 1.0665076464250551 1.1129578985300872 0.9893405629072954 0.9939387785944604 0.8906539494444672 1.0146175080943876 1.0 13.348856348093014 -6.986902379198453 24.870804368423432 0.9693974101781491 1.0315637287089556 0.18743930999434655 0.053107934928475445 341.01807448304527 647549.936701158 0.019622123505031452 0.017296064972467756 1.030617756874995e-07 6.986902379198453 0.062166318530806564 GPTSTSIDNIDGT(ph)PVRDER ddPTM_A459_Selumetinib_30min_R2 4 GPTSTSIDNIDGTPVRDER 19 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 GPTSTSIDNIDGT(1)PVRDER;GPTSTSIDNIDGT(1)PVRDER;GPTSTS(0.001)IDNIDGT(0.999)PVRDER;GPTSTSIDNIDGT(1)PVRDER 174.72 5.2200000000000006e-09 168914700.0 302504.0 271007.0 310235.0 325517.0 315632.0 248616.0 251836.0 255980.0 228824.0 318944.0 True False 285692.03869945824 291792.3654751505 290274.8178583279 281181.02305185393 275979.4863741183 282860.5972886556 263546.87300356716 256724.85942023003 274595.1938767569 309735.25800396735 0.9223749357452836 0.9420702291226174 0.9371707300258655 0.9078108345297012 0.8910173422057858 0.9132334468846052 0.8508778584070381 0.8288525532244756 0.8865480657460044 1.0 18.240676092684218 -6.139640616076484 1.3836708832850664 0.8821831789173924 0.9357836900594664 0.09901147215510075 0.04348311265050741 0.6893043695676347 2.661657255997282 0.01580185190488322 0.02479886992012696 7.250356876789261e-07 6.139640616076484 0.05360051114207398 GPTTGEGALDLSDVHSPPKS(ph)PEGK ddPTM_A459_Selumetinib_30min_R2 2 GPTTGEGALDLSDVHSPPKSPEGK 24 1 O95684;O95684-2 O95684 FGFR1OP FGFR1 oncogene partner 1 GPTTGEGALDLS(0.012)DVHS(0.081)PPKS(0.907)PEGK;GPTTGEGALDLS(0.071)DVHS(0.091)PPKS(0.838)PEGK 48.567 0.021681 6831800.0 56187.0 51442.0 55229.0 57079.0 53154.0 39125.0 45862.0 39770.0 33746.0 50245.0 True False 53064.351474382034 55387.435987899495 51675.62626878855 49304.74173323289 46476.31931721087 44514.113608611886 47994.67387382894 39885.724115722085 40496.14294202108 48794.29629781208 1.0875113589200676 1.1351211143582585 1.0590505487237791 1.0104611701397506 0.9524949193558686 0.9122810858245308 0.9836123792194337 0.8174259522523445 0.8299359969217737 1.0 15.574424896522435 -6.058638484308945 0.8716211850258504 0.8902551711525085 1.126349967992541 0.685318091950027 0.05538758341586334 0.3701044211940099 0.5762822655192344 0.026632520629297805 0.056953788346394474 8.736983503096527e-07 6.058638484308945 0.23609479684003254 GPVGT(ph)VSEAQLAR ddPTM_A459_Selumetinib_30min_R1 1 GPVGTVSEAQLAR 13 0 Q9NZM1-5;Q9NZM1-2;Q9NZM1-6;Q9NZM1;Q9NZM1-3;Q9NZM1-8;Q9NZM1-7 Q9NZM1-5 MYOF Myoferlin 1 GPVGT(0.632)VS(0.368)EAQLAR 169.58 0.00058507 10465000.0 1160.7 944.24 888.66 976.06 1078.9 1268.9 1063.5 1149.4 623.73 747.26 True False 1187.7420516709553 833.6879418347336 767.9848530599678 805.6094439153931 981.3136854952664 1256.1360180690194 983.2793387712378 1118.9141782226204 1058.4242545632167 843.1780999287897 1.408649076359153 0.9887447763469455 0.9108216320191757 0.9554439850648759 1.1638272929267766 1.4897635721031013 1.1661585362028264 1.3270199716016318 1.2552795840553799 1.0 9.719693585764984 -6.521776174526247 24.998412263308108 1.2700796911908505 1.0506134895152592 0.19109364853600386 0.17207007566697827 56.84685561587139 1288922.6390816858 0.055562455816428054 0.05626643612120991 3.0076259651100047e-07 6.521776174526247 -0.21946620167559128 GPVGT(ph)VSEAQLAR ddPTM_A459_Selumetinib_30min_R2 1 GPVGTVSEAQLAR 13 0 Q9NZM1-5;Q9NZM1-2;Q9NZM1-6;Q9NZM1;Q9NZM1-3;Q9NZM1-8;Q9NZM1-7 Q9NZM1-5 MYOF Myoferlin 1 GPVGT(0.757)VS(0.243)EAQLAR 108.23 0.014842 3646200.0 20460.0 11358.0 15840.0 18998.0 18272.0 15662.0 13417.0 14603.0 10774.0 16060.0 True False 19322.915107869372 12229.122078273831 14820.871645288 16410.439626622032 15976.508006247457 17819.298334519593 14040.917085281135 14645.492312343216 12929.101050712236 15596.306071108807 1.238941773761665 0.7841037501134659 0.9502808920083166 1.0522004089815444 1.0243776913203153 1.1425332545588305 0.9002719631984567 0.9390359643860212 0.828984824468314 1.0 13.92891675197381 GPVGTVS(ph)EAQLAR ddPTM_A459_Selumetinib_30min_R2 3 GPVGTVSEAQLAR 13 0 Q9NZM1-5;Q9NZM1-2;Q9NZM1-6;Q9NZM1;Q9NZM1-3;Q9NZM1-8;Q9NZM1-7 Q9NZM1-5 MYOF Myoferlin 1 GPVGT(0.011)VS(0.989)EAQLAR;GPVGT(0.007)VS(0.993)EAQLAR;GPVGT(0.052)VS(0.948)EAQLAR 131.08 0.0015598 14968200.0 34828.0 22645.0 33003.7 34949.0 32151.199999999997 28017.6 29515.0 24856.3 25509.1 29048.0 True False 32892.39918753054 24381.79868484863 30880.27787371159 30188.885909612247 28112.07882062517 31876.77008155003 30887.50598286298 24928.627717818024 30611.63278380576 28209.308764232155 1.1660122359763838 0.8643174807517228 1.0946839616597084 1.0701746066139022 0.9965532674189356 1.1300089040809114 1.094940193005602 0.8837021823599643 1.085160683647081 1.0 14.78388369436934 GPVRS(ph)EDESVEAK ddPTM_A459_Selumetinib_30min_R1 2 GPVRSEDESVEAK 13 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 GPVRS(0.941)EDES(0.059)VEAK;GPVRS(1)EDESVEAK 130.27 0.0077938 17912900.0 4052.8999999999996 5969.0 3910.2000000000003 4388.9 3774.1 4159.0 4500.6 4061.0 2484.4 4022.9 True False 4147.324684429405 5270.146705087183 3379.2163171911484 3622.4610048565337 3432.7333213714746 4117.164236069861 4161.116118546154 3953.289088012927 4215.845346603268 4539.278401364353 0.9136528579482722 1.161009799157319 0.7444390976714428 0.7980257398990431 0.7562288579479309 0.9070085313190706 0.9166911016727821 0.8709069456556581 0.9287479140596725 1.0 12.14824725849652 -10.285020237045973 18.36544767273109 0.9999999999977159 0.8866012532151918 0.0822471181193386 0.11154775173459001 0.0 0.0 0.1136104458524138 0.02755458049547165 5.1877586469680566e-11 10.285020237045973 -0.11339874678252415 GPVRS(ph)EDESVEAK ddPTM_A459_Selumetinib_30min_R2 2 GPVRSEDESVEAK 13 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 GPVRS(0.998)EDES(0.002)VEAK;GPVRS(1)EDESVEAK 87.15700000000002 0.014028 38649000.0 101611.0 85023.0 94487.0 99916.0 101175.0 82686.0 99432.0 100939.0 71124.0 85514.0 True False 95963.86740106123 91543.99070796602 88407.80928966714 86307.26843528618 88464.49198402392 94075.24595122521 104055.78502077023 101232.71577864912 85350.78737060128 83044.98862794493 1.155564820786417 1.10234214274022 1.0645772941910863 1.0392832832087773 1.0652598482535682 1.132822672451647 1.2530049885003547 1.2190105321368416 1.0277656578771623 1.0 16.341605490545625 -6.880252128200061 5.7952745237426 1.1497359003821115 1.0829436053163182 0.027602082381964377 0.07811690853380794 0.44129253931224943 20.68316238962064 0.02800089444095541 0.024701108413547754 1.3174916511487422e-07 6.880252128200061 -0.06679229506579332 GPVS(ph)PSVSFQPLAR ddPTM_A459_Selumetinib_30min_R1 4 GPVSPSVSFQPLAR 14 0 Q7Z434-4;Q7Z434 Q7Z434-4 MAVS Mitochondrial antiviral-signaling protein 1 GPVS(0.977)PS(0.023)VSFQPLAR;GPVS(0.961)PS(0.039)VSFQPLAR;GPVS(0.9)PS(0.071)VS(0.029)FQPLAR;GPVS(0.962)PS(0.037)VS(0.001)FQPLAR 175.6 6.8355e-05 110626400.0 3044.18 3990.3500000000004 4646.679999999999 3653.7 3810.3900000000003 4032.36 3739.14 4692.78 1812.29 2875.19 True False 3115.1034710568515 3523.157966936613 4015.686378386211 3015.6498834433064 3465.740897278994 3991.7981194899417 3457.093659401116 4568.312230102269 3075.323765575446 3244.248643222246 0.9601925788163003 1.0859703908012888 1.2377862550010221 0.929537225743619 1.0682722807080403 1.230422991107493 1.0656068753002448 1.408126420780418 0.9479309707041996 1.0 11.663668678384074 -6.612529410648259 11.420397231062305 1.1517955629129024 1.0601477761943514 0.05322370364449869 0.14254540106834615 1.1870760067776693 143.52135259925763 0.04505728329560483 0.04504907150402374 2.4404537936452427e-07 6.612529410648259 -0.091647786718551 GPVSGS(ph)PDSMNASR ddPTM_A459_Selumetinib_30min_R1 4 GPVSGSPDSMNASR 14 0 A0A499FJS7;O14920-4;O14920-2;O14920 A0A499FJS7 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1 GPVSGS(0.842)PDS(0.158)MNASR;GPVS(0.202)GS(0.661)PDS(0.137)MNASR;GPVS(0.005)GS(0.978)PDS(0.017)MNASR;GPVS(0.456)GS(0.513)PDS(0.031)MNASR 199.33 2.7665e-21 28489900.0 7172.1 8328.9 7393.200000000001 7747.599999999999 7458.5 6747.5 7559.0 6934.200000000001 3925.3999999999996 6731.2 True False 7339.195975522755 7353.748515999442 6389.244047940663 6394.627100464011 6783.879991905124 6679.626276239821 6988.818544214189 6750.282490544017 6661.117100127386 7595.215087440332 0.9662920524343099 0.9682080667023918 0.8412196329378614 0.8419283755424322 0.8931781277824699 0.8794518916634032 0.9201607148388862 0.8887546189055896 0.8770149394639793 1.0 12.890875105372295 -11.499234139396684 7.225078317537583 1.0702267997405475 0.8959272555643235 0.3528133068235114 0.04166521522679044 0.036258363175717546 0.00011865816427592853 0.031034656591131617 0.010578582418366716 3.167859127726809e-12 11.499234139396684 -0.17429954417622395 GPVSGS(ph)PDSMNASR ddPTM_A459_Selumetinib_30min_R2 4 GPVSGSPDSMNASR 14 0 A0A499FJS7;O14920-4;O14920-2;O14920 A0A499FJS7 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1 GPVS(0.064)GS(0.919)PDS(0.017)MNASR;GPVS(0.004)GS(0.851)PDS(0.145)MNASR;GPVS(0.165)GS(0.825)PDS(0.008)MNAS(0.001)R;GPVS(0.072)GS(0.772)PDS(0.157)MNASR 199.33 8.3176e-05 56920000.0 140925.0 120282.0 153802.0 158988.0 160311.0 123187.0 128186.0 160834.0 113419.0 140018.0 True False 133092.95266747268 129507.24263241152 143906.54676695622 137333.5601304024 140171.2989814763 140154.89106975266 134146.9029957402 161302.00031249798 136105.9691916404 135975.31652954637 0.9788023007731159 0.9524319997024652 1.0583284557803287 1.0099888982465497 1.030858412828318 1.0307377445177566 0.9865533423236499 1.1862594214108582 1.0009608557305005 1.0 17.052985258615294 -4.7312856694906165 0.5621227575173281 1.0512851419917026 0.8976070560955683 0.15251997617968016 0.05634908200259508 6.980871073451076 1.6126379365033752 0.030562345193067098 0.7131948674217734 1.8565828334379328e-05 4.7312856694906165 -0.1536780858961343 GPVSGSPDS(ph)MNASR ddPTM_A459_Selumetinib_30min_R1 1 GPVSGSPDSMNASR 14 0 A0A499FJS7;O14920-4;O14920-2;O14920 A0A499FJS7 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1 GPVS(0.001)GS(0.391)PDS(0.608)MNASR 131.08 0.0034848 4100800.0 1992.4 2254.3 2112.8 1892.0 2403.1 1780.5 2131.0 2065.3 1114.6 1815.1 True False 2038.8190434644716 1990.3655080043623 1825.8933647796666 1561.5977172386154 2185.7400293017636 1762.5897865646516 1970.256954322057 2010.5215349601328 1891.394792836902 2048.085765571213 0.9954754228252952 0.9718174607054346 0.8915121600244232 0.7624669549925241 1.0672111813111296 0.8606035041081709 0.9619992421423575 0.9816588586071231 0.9234939398689637 1.0 11.000060415514405 -7.482745176944918 24.752771813458832 0.965911737087672 0.9234529359649516 0.0634801227580718 0.0789232540638379 1480.3649111385294 913031.620676788 0.03324680982450529 0.022411409593282795 3.290446417710083e-08 7.482745176944918 -0.04245880112272038 GPVSGSPDS(ph)MNASR ddPTM_A459_Selumetinib_30min_R2 1 GPVSGSPDSMNASR 14 0 A0A499FJS7;O14920-4;O14920-2;O14920 A0A499FJS7 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1 GPVSGS(0.185)PDS(0.815)MNASR 130.61 0.0036304 3160800.0 17518.0 13175.0 17864.0 16840.0 17671.0 12263.0 12220.0 14808.0 13111.0 17007.0 True False 16544.41969011025 14185.480135697984 16714.64968885257 14546.362949379673 15451.010999255608 13952.116937569528 12788.25421347063 14851.088828403628 15733.566351948037 16515.9637205073 1.0017229372796221 0.8588950893664391 1.0120299348985955 0.8807456346805822 0.9355197953160083 0.8447655355554982 0.7742965793507948 0.8991960190590359 0.9526278101720587 1.0 14.011573534109715 -5.827281701711378 24.999444819546767 0.8881344905381906 0.9476870504646892 0.11593100026783543 0.0699138578525545 114.44945746252247 43453.487548257915 0.01973546672345135 0.029272440443299155 1.4883953285691934e-06 5.827281701711378 0.05955255992649855 GPVSGTEPEPVYS(ph)MEAADYR ddPTM_A459_Selumetinib_30min_R1 1 GPVSGTEPEPVYSMEAADYR 20 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 GPVSGTEPEPVYS(1)MEAADYR 138.82 8.1751e-05 6366900.0 717.89 925.14 857.84 928.91 703.71 819.96 582.21 687.72 403.29 666.96 True False 734.6154402292257 816.8241787140819 741.3500397778255 766.6933063002766 640.0595547500915 811.711946864113 538.29343096004 669.4794315706108 684.353674863803 752.5708127405526 0.9761412850361006 1.085378498455906 0.9850900768767983 1.0187656673905485 0.850497446770834 1.078585474113981 0.715272798050455 0.8895899498581971 0.9093545262161697 1.0 9.555683527637862 -6.2637086951681535 1.1334507515194534 0.8894248578196672 1.0310960884172116 0.21327557701482047 0.09482606770101756 0.6729613162141002 1.7917193866022456 0.0391991298164772 0.058216159767820554 5.448680027800557e-07 6.2637086951681535 0.14167123059754438 GPVSGTEPEPVYS(ph)MEAADYR ddPTM_A459_Selumetinib_30min_R2 2 GPVSGTEPEPVYSMEAADYR 20 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 GPVSGTEPEPVY(0.018)S(0.964)MEAADY(0.018)R;GPVSGT(0.004)EPEPVY(0.016)S(0.98)MEAADYR 93.029 0.0037137 3361600.0 13359.900000000001 16186.5 15314.8 20880.8 17785.2 11375.3 12505.7 13370.099999999999 10906.599999999999 11609.2 True False 12617.410241917107 17427.952502199267 14329.462441493479 18036.79901861087 15550.864174294658 12942.144320307805 13087.239829574431 13409.004777460792 13088.224755865796 11274.01223167599 1.1191588214235428 1.5458518355366762 1.2710171097058733 1.5998562577335014 1.3793549141806167 1.1479625934718214 1.1608325022749144 1.1893729137339613 1.1609198648101968 1.0 13.460713417385909 -6.750264787932341 5.9659557751121675 1.1445257569436966 1.3992351185123355 0.46400978750843036 0.13422707556032606 0.14218216011745083 17.80238755292893 0.04353932342246659 0.04147638038396116 1.7771955293223236e-07 6.750264787932341 0.2547093615686389 GQAGLPGGLVSPGS(ph)GDR ddPTM_A459_Selumetinib_30min_R2 2 GQAGLPGGLVSPGSGDR 17 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 GQAGLPGGLVS(0.082)PGS(0.918)GDR;GQAGLPGGLVS(0.082)PGS(0.918)GDR 88.486 0.010053 11046500.0 70230.0 73276.0 79459.0 88280.0 103183.0 69436.0 58233.0 74465.0 62327.0 84504.0 True False 66326.89775296506 78896.03358052425 74346.69444841771 76256.11170850573 90220.2290722762 79000.1787227496 60940.949886500384 74681.6808216556 74794.14156188417 82064.14995224006 0.8082323132764574 0.9613946361040772 0.9059582593822787 0.9292256332745237 1.0993866277148163 0.962663705999835 0.7426013663940586 0.9100402656351045 0.9114106659901199 1.0 16.324464492153417 -10.289223568618166 24.336020733842126 0.9999999976307612 0.9177650270432735 0.07495661443896984 0.08941831942476236 0.0 0.0 0.09106404771161392 0.022086275730074736 5.137790973269687e-11 10.289223568618166 -0.08223497058748774 GQDVVQEWQET(ph)SPTREEPAGEQK ddPTM_A459_Selumetinib_30min_R1 1 GQDVVQEWQETSPTREEPAGEQK 23 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GQDVVQEWQET(0.436)S(0.367)PT(0.197)REEPAGEQK 58.457 0.019686 15764000.0 2022.6 2144.7 2552.6 2440.2 2259.5 1876.2 2079.1 1949.5 1298.8 1691.0 True False 2069.7226447055 1893.5975269560201 2205.9709404281425 2014.0648782270998 2055.128623947126 1857.3271314532997 1922.2718131069878 1897.792927131544 2203.9687394011926 1908.0563217348488 1.0847282761672676 0.9924222390009524 1.1561351283501018 1.0555584000769251 1.0770796441053458 0.973413158876031 1.007450247254344 0.9946210211478596 1.1550857877178873 1.0 10.897888041900853 -6.687444315988788 24.999966208503796 1.0246081379911574 1.0723273717972062 0.13527874710261 0.05942280202892749 85.2004729495205 28783.24550382961 0.019332998546683886 0.01933299263638505 2.053788340513384e-07 6.687444315988788 0.04771923380604881 GQDVVQEWQETS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 GQDVVQEWQETSPTR 15 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GQDVVQEWQET(0.087)S(0.912)PT(0.001)R;GQDVVQEWQET(0.069)S(0.888)PT(0.043)R 144.08 0.00037477 4245200.0 25579.0 19288.8 23435.0 32040.0 30102.0 24789.0 29154.0 31356.0 27829.0 20671.2 True False 24157.421580849976 20768.18893673255 21927.21761409875 27676.09672791714 26320.31764470559 28203.45973786275 30509.71876755505 31447.240768734755 33395.57760722767 20074.368745772368 1.203396325273615 1.0345624910923437 1.0922992345010396 1.3786783075679867 1.3111404885520301 1.4049487729870638 1.5198345289926165 1.5665369689573674 1.6635929144352661 1.0 14.293067001331265 -6.060926279672737 1.1922137609416508 1.4703673928085355 1.0904007627781398 0.34466330253814637 0.1771304291049768 0.4645405953848043 1.346989379365183 0.06655467442806076 0.1206368188016041 8.69107945515989e-07 6.060926279672737 -0.37996663003039566 GQDVVQEWQETS(ph)PTREEPAGEQK ddPTM_A459_Selumetinib_30min_R2 2 GQDVVQEWQETSPTREEPAGEQK 23 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GQDVVQEWQET(0.243)S(0.592)PT(0.164)REEPAGEQK;GQDVVQEWQET(0.347)S(0.448)PT(0.206)REEPAGEQK 57.339 0.0088529 41220000.0 59842.0 58983.0 58969.0 64041.0 54938.0 45042.0 44446.0 50707.0 39593.0 53049.0 True False 56516.221206506285 63506.80643976274 55174.99874059265 55318.505323113 48036.19728804853 51246.12664943377 46512.827068078164 50854.54897500423 47512.706320851066 51517.33753214513 1.0970330361354954 1.2327268737468542 1.0709986459639003 1.0737842437722265 0.9324277920627306 0.9947355415535181 0.9028577425814306 0.9871346504130315 0.9222663397774524 1.0 15.652770414996821 -5.896555890082441 1.5594114954828822 0.9535352142349492 1.161029115588113 0.7359878962952691 0.04867011595251919 0.17514735661834602 0.8663993899918208 0.014995794732760354 0.028685014117233454 1.2689488307918275e-06 5.896555890082441 0.2074939013531637 GQDVVQEWQETSPT(ph)REEPAGEQK ddPTM_A459_Selumetinib_30min_R1 1 GQDVVQEWQETSPTREEPAGEQK 23 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 GQDVVQEWQET(0.039)S(0.105)PT(0.856)REEPAGEQK 80.41 0.00078529 15384000.0 1860.6 2095.1 2374.2 2481.9 2329.1 1994.7 2049.9 1806.8 1189.6 2061.5 True False 1903.9483599026264 1849.8047180144354 2051.7966805470865 2048.4827560330464 2118.433316236002 1974.6351290426912 1895.2743926160417 1758.8777946864714 2018.664315053633 2326.1136057104623 0.8185104782623485 0.7952340390741369 0.8820707103514012 0.8806460488447986 0.9107179077734561 0.8488988346033859 0.8147815257016091 0.7561444077230525 0.8678270528567217 1.0 11.183705843378934 -5.254874092207825 24.740860118846307 0.8605160069188763 0.8068722540857116 0.13499021669024314 0.06024136456697254 1023.9512741685833 3858661.6790919555 0.015651340439764447 0.03935995544633933 5.5606544473075284e-06 5.254874092207825 -0.05364375283316469 GQES(ph)PLKK ddPTM_A459_Selumetinib_30min_R2 1 GQESPLKK 8 1 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 GQES(1)PLKK 62.166 0.048162 7745400.0 117270.0 90361.0 71978.0 91198.0 82271.0 89640.0 181950.0 222710.0 114320.0 166440.0 True False 110752.60286900488 97291.39814359072 67347.0138437208 78776.67507467492 71935.38146792822 101987.09632909826 190411.03552708513 223358.04922837473 137187.19436768346 161634.44473694547 0.6852042152849966 0.6019224324489074 0.416662512457204 0.48737554178431003 0.44504982576579266 0.6309737784856363 1.1780350149807028 1.381871602874513 0.8487497487985988 1.0 17.30237514750125 -7.194079814811505 4.4196335882174385 1.1350315458522724 0.5258262644038523 0.7746760866755491 0.1474582482708482 0.09719995801380714 3.743490245412281 0.05872605217179638 0.0441873305086896 6.396172755647133e-08 7.194079814811505 -0.6092052814484201 GQFSTDELVAEVEKR ddPTM_A459_Selumetinib_30min_R1 1 GQFSTDELVAEVEKR 15 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 114.06 0.0035286 4060100.0 2648.0 3119.3 2512.8 2563.7 1884.8 2469.6 2687.2 1652.4 1819.6 2382.3 False True 2709.693247888936 2754.090905876771 2171.57556182239 2115.9979216092174 1714.3201727884673 2444.7580662173905 2484.502340522868 1608.5729842483531 3087.728301674168 2688.0914105670768 1.0080361245294491 1.0245525487155107 0.807850340686248 0.7871748383596928 0.6377462336471721 0.9094772806485949 0.9242625941796898 0.5984070995223374 1.1486693828699763 1.0 11.392366483541217 -5.258358602190859 24.48067666406936 0.8320654028530179 1.016294364018127 0.14468061577777147 0.1542812706730768 311.278616113361 2473456.474403271 0.03775393709101159 0.09141144248612404 5.51621770433169e-06 5.258358602190859 0.18422896116510912 GQFSTDELVAEVEKR ddPTM_A459_Selumetinib_30min_R2 1 GQFSTDELVAEVEKR 15 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 168.05 9.2969e-05 2917500.0 10559.0 9569.8 12421.0 12902.0 14288.0 7311.4 7789.4 7699.8 7850.4 11987.0 False True 9972.17305102604 10303.77288824308 11621.846382962261 11144.725342808584 12493.013703659344 8318.478983718976 8151.622534403284 7722.205143229492 9420.699358503001 11640.904164033702 0.856649355626219 0.8851351014535549 0.998362860753521 0.9573762644006524 1.0731996009604101 0.714590453327513 0.7002568202209696 0.6633681571821877 0.8092755705016151 1.0 13.506915498131365 -6.776715894768254 24.996412969231258 0.7516310849282599 0.9529468859190633 0.41046686198792826 0.10355014806708987 210.1924948726844 343928.2404364191 0.035741804570357256 0.03163763981789362 1.6721841601192364e-07 6.776715894768254 0.20131580099080337 GQGESDPLDHEPAVS(ph)PLLPR ddPTM_A459_Selumetinib_30min_R1 5 GQGESDPLDHEPAVSPLLPR 20 0 P00519;P00519-2 P00519 ABL1 Tyrosine-protein kinase ABL1 1 GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR 176.77 2.8399e-13 134597400.0 9291.810000000001 10786.810000000001 10774.519999999999 11021.27 12846.599999999999 8982.98 10254.58 9902.38 4023.0999999999995 7123.379999999999 True False 9508.291094285083 9523.885270548077 9311.399364201916 9096.612089360704 11684.627298251438 8892.619377093253 9481.068774590278 9639.736714936587 6826.906864401708 8037.735210597034 1.1829564977145868 1.1848966183896785 1.1584605762983669 1.1317382136907963 1.4537213521100203 1.1063588366744317 1.179569683023439 1.1993100621462944 0.8493570247749693 1.0 12.972573335727468 -8.251409558309364 24.592670386531715 0.9246785160950407 1.20019270610602 0.5684763281359095 0.09581908177891907 340.5864027593042 835108.6297003595 0.0655309276914136 0.0241018580101145 5.6051913314570676e-09 8.251409558309364 0.2755141900109793 GQGESDPLDHEPAVS(ph)PLLPR ddPTM_A459_Selumetinib_30min_R2 6 GQGESDPLDHEPAVSPLLPR 20 0 P00519;P00519-2 P00519 ABL1 Tyrosine-protein kinase ABL1 1 GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR;GQGESDPLDHEPAVS(1)PLLPR 208.28 1.0601e-16 116284700.0 94121.1 94900.0 144807.5 130497.8 149892.0 102963.7 95558.90000000001 103372.40000000001 93381.6 122232.9 True False 88890.22605861606 102178.52484840532 135490.74310448472 112723.7745187384 131061.22690851805 117146.01506359194 100002.57819636822 103673.19656977792 112060.52929990644 118703.71857778533 0.7488411241335056 0.8607862169157638 1.1414195336744992 0.9496229424764959 1.1041038012860143 0.9868773823359827 0.8424553113796309 0.8733778335835531 0.9440355419571319 1.0 16.857005604780568 -10.36285714699411 14.83245518686563 1.0000013158695125 0.9445031926488276 0.02367536243643753 0.11262111968206591 0.0 0.0 0.11538971914658525 0.027986117655983977 4.336534970963591e-11 10.36285714699411 -0.055498123220684814 GQGGAGAGDDEEED ddPTM_A459_Selumetinib_30min_R1 1 GQGGAGAGDDEEED 14 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 126.39 0.018032 1021600.0 1208.6 1171.2 1081.6 1292.5 1209.6 993.33 1130.6 1279.4 484.89 959.73 False True 1236.75802847378 1034.0753595238925 934.724660803525 1066.7891382298692 1100.1918935722251 983.3380020714776 1045.3179317487184 1245.4661559231085 822.8229150356053 1082.9206940618487 1.1420578028063293 0.9548948184241028 0.8631515363304528 0.9851036590948569 1.0159487205342759 0.9080424886730591 0.9652765317725263 1.1500991372245182 0.7598182577427147 1.0 10.08071187804872 -4.7606107984108315 24.71770832756561 0.9592070982823999 1.1420580404300624 0.2493841001524314 0.09677288287470688 25.22980438095184 752113.1036917323 0.022818001151823437 0.13386964395123901 1.7353584769314346e-05 4.7606107984108315 0.1828509421476625 GQGS(ph)SPVAMQK ddPTM_A459_Selumetinib_30min_R1 3 GQGSSPVAMQK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 GQGS(0.5)S(0.5)PVAMQK;GQGS(0.5)S(0.5)PVAMQK;GQGS(0.727)S(0.273)PVAMQK 180.61 4.679e-05 135944200.0 17747.6 15819.0 15976.5 15370.8 16761.8 13072.2 17230.4 15621.499999999998 9109.4 13952.9 True False 18161.084549181913 13966.904125946416 13806.9790526327 12686.578325650808 15245.698149536154 12940.70553660794 15930.697055725372 15207.167074216684 15457.986475747794 15743.890627755261 1.1535321845519764 0.8871316789589382 0.8769737658296523 0.805809607396875 0.9683564571173511 0.8219509295748332 1.011865328106433 0.9659090903113634 0.9818403113456948 1.0 13.942504483023235 -7.310334843116803 24.99898002209906 0.987062791763171 0.9127059714991327 0.12335858507551112 0.09162188352713029 844.0149236673043 431519.6354682995 0.03830252364801983 0.025823644594380094 4.894013430995401e-08 7.310334843116803 -0.07435682026403834 GQGS(ph)SPVAMQK ddPTM_A459_Selumetinib_30min_R2 4 GQGSSPVAMQK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 GQGS(0.5)S(0.5)PVAMQK;GQGS(0.973)S(0.027)PVAMQK;GQGS(0.5)S(0.5)PVAMQK;GQGS(0.5)S(0.5)PVAMQK 191.48 1.9986e-05 218715000.0 340073.0 325416.0 421228.0 475163.0 459619.0 360445.0 405945.0 450065.0 360516.0 375323.0 True False 321173.1040800812 350374.3608226411 394126.6490783702 410444.97969810537 401877.5521740065 410093.02695606666 424822.2468647578 451374.6146377281 432629.27365867543 364486.44978373405 0.8811661017045969 0.9612822672297797 1.0813204422612226 1.1260911892380103 1.1025857131656285 1.1251255765458306 1.1655364612781178 1.2383851715353167 1.1869557123875896 1.0 18.47550565608592 -4.769410199888125 0.7910726887923273 1.156137604635277 0.6966891446269189 0.6761200586955813 0.05916353753573749 1.4645774555778808 0.6908083160398691 0.022775106175013937 0.5996760996692959 1.7005515444138513e-05 4.769410199888125 -0.45944846000835804 GQGSS(ph)PVAMQK ddPTM_A459_Selumetinib_30min_R1 1 GQGSSPVAMQK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 GQGS(0.225)S(0.775)PVAMQK 83.647 0.037693 2299200.0 1440.2 1251.1 1171.5 1074.6 1273.7 1249.7 1330.5 1298.5 789.6 1081.5 True False 1473.753857858627 1104.6206303793895 1012.4167345888774 886.9412827402834 1158.4940598899993 1237.1291526368143 1230.1393138083042 1264.0595618775644 1339.8935298977385 1220.321059702092 1.207677148682826 0.9051885334577872 0.829631453575038 0.7268097814822649 0.9493354643677246 1.0137735006710655 1.008045631949193 1.035841799031273 1.0979844355262023 1.0 10.253045047452847 -6.704136834331491 3.7391196943511384 1.03344955014509 0.9032169226160635 0.1731343039127502 0.11658824014429421 0.3905595274338605 11.069580252201977 0.043060202775016355 0.041667328391305956 1.9763468490829188e-07 6.704136834331491 -0.13023262752902653 GQGTPPS(ph)GPGVVR ddPTM_A459_Selumetinib_30min_R2 2 GQGTPPSGPGVVR 13 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 GQGT(0.078)PPS(0.922)GPGVVR;GQGT(0.034)PPS(0.966)GPGVVR 122.63 0.0026100000000000003 63359000.0 134430.0 125465.0 131744.0 149462.0 162691.0 115853.0 120992.0 124661.0 111362.0 129106.0 True False 126958.91876592752 135087.76206644005 123267.73447202184 129105.01776366869 142252.3021040063 131810.69914117616 126618.36774109975 125023.7428712606 133637.51171425788 125378.37432232685 1.012606196659859 1.0774406894059096 0.9831658381143233 1.0297231756392156 1.1345840371027573 1.051303303728543 1.009890010342494 0.9971715102147157 1.0658736998032705 1.0 16.935929003211086 -11.29786146147953 6.846347541835657 0.9988405915084133 1.0402515866935653 0.07485207219477241 0.04239326564281492 0.0007988963788493603 2.6257125117974794e-05 0.043709797865103726 0.010307583674463635 5.036612494572509e-12 11.29786146147953 0.04141099518515201 GQHHQQQQAAGGSESHPVPPTAPLT(ph)PLLHGEGASQQPR ddPTM_A459_Selumetinib_30min_R2 1 GQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGASQQPR 38 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 GQHHQQQQAAGGSESHPVPPT(0.093)APLT(0.904)PLLHGEGAS(0.003)QQPR 63.433 1.5979e-05 10405000.0 1870.4 3543.3 6150.5 5530.6 7061.3 3465.8 5419.4 4410.4 4627.1 4351.2 True False 1766.4506558044416 3815.059716494775 5754.78352615807 4777.32273918285 6174.196365177055 3943.182490600056 5671.412838337377 4423.233533818977 5552.649291976109 4225.569550224693 0.4180384761884966 0.9028510053258764 1.3618953510899052 1.130574868641984 1.4611512819257098 0.9331718348809048 1.3421653036182548 1.046778068907604 1.3140593773165679 1.0 12.044930095147084 -4.877725234710426 2.8580060956824234 1.202168749306661 0.3583009066805357 0.6783964999830117 0.16516424326718507 0.17538090060689254 2.313674654856925 0.039074176609947185 0.3135082219963416 1.3251796720669916e-05 4.877725234710426 -0.8438678426261254 GQKS(ph)PGALETPSAAGSQGNTASQGK ddPTM_A459_Selumetinib_30min_R1 1 GQKSPGALETPSAAGSQGNTASQGK 25 1 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 GQKS(0.71)PGALET(0.289)PS(0.001)AAGSQGNTASQGK 97.913 3.1424e-06 4006600.0 1055.8 1277.8 2334.8 2273.5 1676.5 1404.1 1196.2 1216.6 705.18 743.65 True False 1080.3980857708232 1128.1945819668958 2017.7469841383793 1876.4759038805478 1524.8608710101146 1389.976028820797 1105.9696709338552 1184.3318159262571 1196.6389556905867 839.1047212644112 1.2875604896404556 1.344521790160908 2.4046426304191475 2.236283334281526 1.8172473975743655 1.6564988774301035 1.3180353332624761 1.4114231345780512 1.4260901236348933 1.0 9.71270706172816 -7.101594499729864 2.492834823395623 1.3155171768697063 1.8462436638265032 0.3498353428962584 0.3392272148866226 0.39284069544480943 4.779380436596295 0.16326136978326816 0.12155659325819249 7.914172285086043e-08 7.101594499729864 0.5307264869567969 GQKS(ph)PGALETPSAAGSQGNTASQGK ddPTM_A459_Selumetinib_30min_R2 2 GQKSPGALETPSAAGSQGNTASQGK 25 1 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 GQKS(0.99)PGALET(0.01)PSAAGSQGNTASQGK;GQKS(0.65)PGALET(0.347)PS(0.003)AAGSQGNTASQGK 136.24 2.254e-08 24922000.0 84941.0 132776.0 101614.0 105176.0 101744.0 57485.0 39352.0 40156.0 29348.0 112716.0 True False 80220.31926576397 142959.49225786992 95076.2658689581 90850.84736127984 88962.00911709934 65403.036953126 41181.94597450869 40272.84731181636 35218.42005163378 109461.59620866098 0.7328626846701937 1.3060241875639529 0.8685810289822481 0.8299791936899547 0.8127234774424051 0.5974975627840432 0.3762227795034679 0.36791759582097006 0.32174224816253116 1.0 16.740065274150112 -6.578863243356367 1.3515268705514074 0.4626456869771851 0.9841053266428577 0.4077987956067063 0.2283493309602904 0.35552648395338865 1.3498071563689913 0.09579609161922208 0.10174792576090513 2.637161680977781e-07 6.578863243356367 0.5214596396656725 GQLAS(ph)PDAPGPGPR ddPTM_A459_Selumetinib_30min_R2 1 GQLASPDAPGPGPR 14 0 O75154;O75154-3 O75154 RAB11FIP3 Rab11 family-interacting protein 3 1 GQLAS(1)PDAPGPGPR 98.281 0.01625 0.0 11316.0 7609.5 11135.0 10919.0 13897.0 9229.7 9552.1 11577.0 8140.6 10703.0 True False 10687.102021537132 8193.12418160105 10418.586222871336 9431.813363674386 12151.13461924369 10501.007396125378 9996.291577127076 11610.687153324481 9768.947467368478 10393.976580266342 1.028201472170652 0.7882569407705077 1.0023676830917356 0.9074306922704937 1.1690554164142941 1.0102973885916042 0.9617388975174047 1.1170591990141814 0.9398662188555895 1.0 13.343460092987542 GQPEGPLPSS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 2 GQPEGPLPSSSPR 13 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 GQPEGPLPS(0.017)S(0.492)S(0.492)PR;GQPEGPLPS(0.04)S(0.48)S(0.48)PR 147.7 0.00056637 18955200.0 8242.3 9441.599999999999 9100.4 9867.599999999999 9381.4 8271.8 8632.2 7612.7 4974.8 7007.0 True False 8434.329553276055 8336.173082719246 7864.615664919012 8144.4088977926895 8532.854026420697 8188.593202193482 7981.066204175907 7410.786466465406 8441.872254983877 7906.416703959839 1.0667701778293341 1.054355391936801 0.9947130235344297 1.0301011447718984 1.0792315085223265 1.0356895555596404 1.0094416349417406 0.9373129122771632 1.0677241753215285 1.0 12.948808278384467 -7.290202729408892 4.166146484493394 0.9974159607699564 1.0430524426265966 0.22268530711257029 0.03626844934948558 0.31470231487323125 12.779201746576554 0.015411519891030291 0.01053585568205204 5.126220352863885e-08 7.290202729408892 0.045636481856640154 GQPEGPLPSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 GQPEGPLPSSSPR 13 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 GQPEGPLPSS(0.027)S(0.973)PR;GQPEGPLPS(0.001)S(0.034)S(0.965)PR 201.3 9.7435e-05 46162000.0 9932.7 12508.2 12115.400000000001 12252.6 10749.3 10045.0 11035.2 10604.5 5769.1 9565.6 True False 10164.112584330223 11043.73412909558 10470.195225128542 10112.913419787454 9777.027712943054 9943.956420130267 10202.805979509512 10323.234211729396 9789.741341607194 10793.437936834343 0.9416937072147841 1.0231896633608333 0.9700519228815239 0.9369501616603093 0.9058307251276606 0.9212964838751624 0.9452786071702692 0.9564361487177035 0.9070086286592826 1.0 13.397866846268114 -5.673988612974296 4.1099772514570905 0.9352224050641487 0.9852712926733503 0.24300936607592138 0.03158529323970531 0.24927880992535587 7.832582519767423 0.008361110113635491 0.014898259393811335 2.118416678549046e-06 5.673988612974296 0.050048887609201675 GQPEGPLPSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 GQPEGPLPSSSPR 13 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 GQPEGPLPSS(0.025)S(0.975)PR;GQPEGPLPSS(0.031)S(0.969)PR;GQPEGPLPSS(0.027)S(0.973)PR;GQPEGPLPS(0.002)S(0.057)S(0.94)PR 180.85 0.00011339 78682000.0 239868.0 188462.0 249830.0 272714.0 286715.0 237980.0 254367.0 261786.0 229455.0 237814.0 True False 226537.09682768382 202916.4293991583 233756.2097943377 235569.8827421094 250695.2984353783 270759.5848326506 266195.5695186485 262547.7539189946 275352.41150836984 230947.6919050224 0.9809021902710661 0.8786250588839313 1.012160839825454 1.020014016156472 1.0855068364938547 1.172384892004034 1.1526227749793743 1.136827788809285 1.1922717617875522 1.0 17.817206602378178 -6.025173032814937 1.3155362798011796 1.1406176386253801 0.9341855767534525 0.6433965515042791 0.05721586463822369 0.244830283862888 0.8600445718259595 0.019880322823959067 0.03579912040429982 9.436848158473441e-07 6.025173032814937 -0.20643206187192764 GQPS(ph)PLAQVQQ ddPTM_A459_Selumetinib_30min_R2 1 GQPSPLAQVQQ 11 0 P45983-5;P45983-3;P45983-2 P45983-5 1 GQPS(1)PLAQVQQ 90.926 0.027139 3173700.0 26297.0 27806.0 38074.0 51891.0 52233.0 42970.0 37291.0 40975.0 56190.0 41335.0 True False 24835.518015231715 29938.630789618077 35624.360291836805 44823.35628303208 45671.023571055324 48888.7274571771 39025.10539071464 41094.23046622359 67429.5700797772 40141.55114877226 0.6186985132484427 0.7458264549533671 0.8874684528210212 1.1166323921292467 1.1377493461024908 1.2179082785312936 0.9721872791133591 1.0237329971111608 1.67979482979794 1.0 15.292808745911257 -5.426920566028372 1.2045196544304775 1.173164347706179 0.5911963508517606 0.5268808147353665 0.18839420112404712 0.5249436643809487 1.2610371120856831 0.06212498902238183 0.2882710671169908 3.741790206582298e-06 5.426920566028372 -0.5819679968544185 GQPSSAEPEDAAGS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 GQPSSAEPEDAAGSR 15 0 Q03169;H0YKI8 Q03169 TNFAIP2 Tumor necrosis factor alpha-induced protein 2 1 GQPSSAEPEDAAGS(1)R 92.633 0.022478 0.0 4903.2 3637.9 4910.8 4289.9 6200.4 5181.9 4755.9 4682.2 4408.9 6920.3 True False 4630.6997730647645 3916.9152323078347 4594.844474474765 3705.6082195097283 5421.4503197207005 5895.659688395297 4977.058773637068 4695.8244268200615 5290.803194958712 6720.492957901258 0.6890416822207169 0.5828315358477881 0.6837064636862128 0.5513893463950527 0.8067042631666955 0.877265957322936 0.7405794195179625 0.6987321400730282 0.7872641528086619 1.0 12.714351345320221 -6.277099093656743 24.295303644859725 0.8024107838885582 0.6276746519043493 0.5386654900882851 0.08613992354999794 467.51632726741263 725327.4917172577 0.026147490503711852 0.029760532573801575 5.283246893438e-07 6.277099093656743 -0.1747361319842089 GQS(ph)SPPPAPPICLR ddPTM_A459_Selumetinib_30min_R2 3 GQSSPPPAPPICLR 14 0 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 GQS(0.5)S(0.5)PPPAPPICLR;GQS(0.925)S(0.075)PPPAPPICLR;GQS(0.5)S(0.5)PPPAPPICLR 177.21 7.0144e-05 96534000.0 135711.0 119156.0 140539.0 152517.0 166274.0 127022.0 135426.0 141995.0 124786.0 129179.0 True False 128168.72591417689 128294.88205307219 131496.8737472938 131743.92149349986 145385.1736115801 144518.12750908884 141723.57734152817 142408.18194146245 149746.68681215672 125449.26662265006 1.0216777615743815 1.0226833963006075 1.048207592499005 1.0501768965280924 1.1589160903498705 1.152004562480207 1.1297282252580325 1.1351854480730015 1.1936832382017268 1.0 16.936744511202562 -6.160626905669045 4.555847131411415 1.1361319888837256 1.0329477008151142 0.4670170734720338 0.04819545203996982 0.18224819584152385 6.28886028116882 0.013591637462226202 0.017779064598826506 6.908330308268039e-07 6.160626905669045 -0.10318428806861135 GQSPAGDGS(ph)PEPPTPR ddPTM_A459_Selumetinib_30min_R1 1 GQSPAGDGSPEPPTPR 16 0 A0A0A0MRW6;Q9H6R4-2;Q9H6R4-4;Q9H6R4;Q9H6R4-3 A0A0A0MRW6 NOL6 Nucleolar protein 6 1 GQS(0.047)PAGDGS(0.951)PEPPT(0.002)PR 137.52 0.00053588 0.0 1523.9 1885.2 2031.3 2223.3 1922.1 2224.5 1910.8 1504.4 1121.9 1592.0 True False 1559.4039050067797 1664.479907594297 1755.4606171322125 1835.0423915098386 1748.246394374316 2202.1235496843974 1766.6668176060953 1464.4984250201055 1903.782359665998 1796.3487073931874 0.8680964328299846 0.9265906450923691 0.9772382221265321 1.0215401853534343 0.9732221740573542 1.2258886822036126 0.9834765434656806 0.815263995789184 1.0598066799784744 1.0 10.810851718034518 -5.076317421420057 1.594733267398674 1.0099162833027067 0.8550036826565236 0.1952414044479639 0.09462981624174269 1.1190950957173693 4.059500777446775 0.028981722545753315 0.22724259289330254 8.388466579176643e-06 5.076317421420057 -0.15491260064618306 GQSPAGDGS(ph)PEPPTPR ddPTM_A459_Selumetinib_30min_R2 1 GQSPAGDGSPEPPTPR 16 0 A0A0A0MRW6;Q9H6R4-2;Q9H6R4-4;Q9H6R4;Q9H6R4-3 A0A0A0MRW6 NOL6 Nucleolar protein 6 1 GQS(0.269)PAGDGS(0.731)PEPPTPR 180.03 1.0354e-06 3268900.0 24185.0 18286.0 24384.0 29036.0 30295.0 22399.0 18891.0 25093.0 19257.0 25118.0 True False 22840.894520225833 19688.47740124276 22815.15998729182 25081.246710106177 26489.071259263714 25484.258932122633 19769.468931806354 25166.016475630233 23108.93808553607 24392.778075598442 0.9363793844816285 0.807143710331966 0.9353243782476417 1.0282242814809377 1.0859390913641902 1.0447460659520396 0.8104640181014453 1.0316994807903945 0.9473680289271079 1.0 14.57416645452041 -5.5163334321574995 6.5018415840380515 0.991883976216845 0.871054683823944 0.2891656282495302 0.0760744477849193 0.17875846092803516 36.39122566569465 0.02114905184517168 0.040295097833770076 3.0455558482799334e-06 5.5163334321574995 -0.12082929239290097 GQSPAGDGSPEPPT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 GQSPAGDGSPEPPTPR 16 0 A0A0A0MRW6;Q9H6R4-2;Q9H6R4-4;Q9H6R4;Q9H6R4-3 A0A0A0MRW6 NOL6 Nucleolar protein 6 1 GQS(0.001)PAGDGS(0.496)PEPPT(0.503)PR 110.32 0.0065875 7835500.0 1224.1 1311.3 1682.5 1589.4 1677.3 1224.2 1302.3 1315.6 752.8 1229.9 True False 1252.61914831603 1157.772386393169 1454.0257413109578 1311.8411267331167 1525.5885111513664 1211.8856594846657 1204.0664625122554 1280.7060143289355 1277.446617663396 1387.7696452405023 0.9026131625028803 0.8342684179351145 1.0477428630159822 0.9452873762098845 1.0993096126461102 0.8732613972649937 0.8676270349634208 0.9228520156217911 0.9205033573435834 1.0 10.438552400669487 -4.331007651709029 0.003614618821466608 1.8604457225331335 2.7690637207408286e-08 0.02151865859614388 0.0788502314040154 503333.3594087008 249.71253658907227 62354.968732796166 66216.55694234293 4.6665115844989324e-05 4.331007651709029 -1.8604456948424963 GQSPAGDGSPEPPT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GQSPAGDGSPEPPTPR 16 0 A0A0A0MRW6;Q9H6R4-2;Q9H6R4-4;Q9H6R4;Q9H6R4-3 A0A0A0MRW6 NOL6 Nucleolar protein 6 1 GQSPAGDGS(0.007)PEPPT(0.993)PR 164.8 5.1137e-05 3438400.0 8236.9 8843.6 11172.0 11491.0 12928.0 8962.2 10060.0 11884.0 8263.9 8998.7 True False 7779.126072923228 9521.875683344117 10453.205683153888 9925.905976919348 11303.869062213613 10196.661699248607 10527.809933511831 11918.580472497895 9916.91091265833 8738.884149569534 0.8901738413944322 1.0895985712103933 1.1961716741225823 1.1358321963117322 1.2935140080522096 1.1668150675450801 1.2047087194799828 1.3638561020499382 1.134802881343475 1.0 13.093233361338061 -4.453993722323826 1.2273463138096032 1.2068362255022407 0.5004743893632237 0.4783001889615215 0.09299517840326242 2.2654556678894986 1.7310534743378425 0.02615836917489898 2.464649623826169 3.515655223302644e-05 4.453993722323826 -0.7063618361390169 GQSPPS(ph)KDGSGDYQSR ddPTM_A459_Selumetinib_30min_R2 1 GQSPPSKDGSGDYQSR 16 1 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 GQS(0.034)PPS(0.966)KDGSGDYQSR 56.793 0.047585 1598900.0 15911.0 16694.0 16129.0 21494.0 17530.0 13179.0 12475.0 13312.0 10396.0 15718.0 True False 15026.730316779554 17974.376120329584 15091.2776999274 18566.48012078187 15327.72467981161 14994.287622949423 13055.112218743545 13350.73571607977 12475.490488509775 15264.180499731512 0.9844439612754753 1.1775526449419111 0.9886726444431685 1.2163430667704986 1.0041629604734572 0.9823185478718077 0.8552776363574301 0.8746447748252585 0.8173049636519439 1.0 13.897862516050576 -6.865666014491927 1.9973288747527236 0.8774908656621655 1.0897633145146377 0.5340460840307943 0.08306527293009414 0.22753721072234684 1.8597446584138912 0.032508693092905834 0.027756455300930814 1.362492077028455e-07 6.865666014491927 0.2122724488524722 GQSQLS(ph)NPTDDSWK ddPTM_A459_Selumetinib_30min_R1 3 GQSQLSNPTDDSWK 14 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 GQSQLS(0.577)NPT(0.421)DDS(0.001)WK;GQSQLS(0.994)NPT(0.005)DDSWK;GQSQLS(0.99)NPT(0.01)DDSWK 298.7 6.717899999999997e-80 49268000.0 8854.5 11657.0 10201.8 10761.4 8796.9 9218.0 9139.0 9285.5 5056.1 7894.3 True False 9060.79262214222 10292.193020807726 8816.451594476146 8882.12350649664 8001.221948218842 9125.27528927434 8449.637872148885 9039.21837644522 8579.832417066807 8907.610301993735 1.0171967918392433 1.1554381783522893 0.989766199415214 0.9971387617292384 0.8982456210986216 1.024435845294207 0.9485863868851173 1.0147747903185693 0.9632024893530016 1.0 13.120822727870967 -5.394996419612242 7.057265778508555 0.977378464525936 1.0857531689821678 0.4616615295897937 0.04624662639675216 0.18872900321622219 9.909619302224304 0.011285946757359827 0.023667951388823005 4.027203543977681e-06 5.394996419612242 0.10837470445623176 GQSQLS(ph)NPTDDSWK ddPTM_A459_Selumetinib_30min_R2 2 GQSQLSNPTDDSWK 14 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 GQSQLS(0.637)NPT(0.186)DDS(0.178)WK;GQSQLS(0.907)NPT(0.093)DDSWK 254.89 4.4498e-28 35700300.0 75031.0 49527.0 70024.0 73842.0 78996.0 51609.0 53302.0 61713.0 55536.0 63970.0 True False 70861.0773928908 53325.56164559499 65518.73207636663 63784.59221544494 69071.81624679973 58717.67129014319 55780.64861590927 61892.57461286287 66644.75180549054 62123.01988597943 1.1406573203129724 0.8583865005833379 1.0546610933695704 1.0267464835501423 1.1118554180652216 0.9451837885201586 0.8979062627394652 0.9962905011131216 1.072786737151708 1.0 15.922840342382043 GQSQLSNPT(ph)DDSWK ddPTM_A459_Selumetinib_30min_R1 1 GQSQLSNPTDDSWK 14 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 GQSQLS(0.199)NPT(0.785)DDS(0.017)WK 288.06 4.049099999999998e-66 16198000.0 2805.8 3436.8 3130.9 2941.1 2889.6 2926.3 2530.6 3034.9 1664.2 2493.4 True False 2871.1696808635866 3034.417858275028 2705.740976802659 2427.492096284616 2628.236190200316 2896.864078867813 2339.7148046022526 2954.4045932554636 2824.0258516411027 2813.4521777727196 1.02051483353684 1.0785389857513898 0.9617156453480825 0.8628161926698713 0.9341677142992952 1.0296475276011718 0.8316170514952549 1.0500994531189543 1.0037582561210454 1.0 11.458125725762729 -5.301318566853132 9.04956245578994 0.9545574923753573 1.049462787147013 0.22271004140618955 0.06703108413674308 0.5342977098724451 117.81894091754647 0.017638955480289636 0.037107930740554754 4.996678804930337e-06 5.301318566853132 0.09490529477165577 GQSQLSNPT(ph)DDSWK ddPTM_A459_Selumetinib_30min_R2 2 GQSQLSNPTDDSWK 14 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 GQSQLS(0.204)NPT(0.431)DDS(0.365)WK;GQSQLS(0.252)NPT(0.584)DDS(0.163)WK 208.38 1.4103e-05 32412000.0 73697.3 53683.8 68690.3 76871.5 77020.5 51298.3 61604.3 63512.7 45215.2 67088.1 True False 69601.4990996668 57801.17483937635 64270.84088234387 66401.4690892659 67344.49621799376 58364.175185396976 64469.02201660466 63697.511441906456 54259.50341824428 65151.092237182784 1.0683090138578537 0.8871865820599134 0.9864890775486257 1.019191955332554 1.0336664191726193 0.8958280388135627 0.9895309472618655 0.977689080177128 0.8328256910983528 1.0 15.991501744865628 -8.060802414324954 24.996991045131914 0.9126941935856122 0.979649753215785 0.14013306036511153 0.06485604378596235 449.5866481164129 184830.13230177845 0.0415268188638303 0.01569570598557767 8.69355859582757e-09 8.060802414324954 0.06695555963017275 GQSQTS(ph)PDHR ddPTM_A459_Selumetinib_30min_R2 2 GQSQTSPDHR 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GQS(0.005)QT(0.114)S(0.881)PDHR;GQSQT(0.063)S(0.937)PDHR 103.43 0.01423 439600.0 9668.3 7748.09 8867.1 16488.8 10657.599999999999 5893.219999999999 16405.8 24017.1 14297.6 15260.7 True False 9130.974591271424 8342.343588963962 8296.600439768506 14242.996995233452 9318.69700784713 6704.957561675244 17168.702207475973 24086.985784755063 17157.519508322188 14820.083938939597 0.6161216514624385 0.5629079850920785 0.5598214203071608 0.9610604807581518 0.628788409447693 0.4524237237319585 1.1584753688449367 1.6252934790380498 1.1577208050246603 1.0 13.855265998444812 -7.387570986707725 5.046982290540634 1.3098256189967068 0.6408470362153752 0.700142436775794 0.1935361043522066 0.11956371496350111 4.406916777942013 0.08263817960860761 0.05458715448960003 4.0966514337070564e-08 7.387570986707725 -0.6689785827813316 GQSS(ph)PPPAPPICLR ddPTM_A459_Selumetinib_30min_R1 1 GQSSPPPAPPICLR 14 0 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 GQS(0.075)S(0.925)PPPAPPICLR 203.32 3.6794e-05 56285000.0 2897.4 3749.1 2961.6 2987.6 3062.0 3121.6 3262.7 2942.2 1550.7 2805.1 True False 2964.9037826410135 3310.1536290906975 2559.4309869043273 2465.871744197723 2785.0426406400084 3090.1995381860243 3016.5919121851616 2864.1632983875015 2631.424641353119 3165.1619089878327 0.9367305268718912 1.0458086266270121 0.8086256123696344 0.7790665422819614 0.8799052689000102 0.976316418256853 0.953060854049586 0.9049026181739355 0.8313712590439349 1.0 11.628063585048523 -6.682008766155958 24.999867531618918 0.9284423627421593 0.8879947443116415 0.0663633546139526 0.07969073235312815 117.58784057234294 37002.24103288021 0.028807915436347604 0.02880790810384998 2.0796547092240054e-07 6.682008766155958 -0.04044761843051781 GQSTDS(ph)LPQTICR ddPTM_A459_Selumetinib_30min_R2 2 GQSTDSLPQTICR 13 0 Q96NE9-2;Q96NE9;Q96NE9-3 Q96NE9-2 FRMD6 FERM domain-containing protein 6 1 GQS(0.002)T(0.002)DS(0.996)LPQTICR;GQS(0.272)T(0.015)DS(0.713)LPQT(0.001)ICR 147.83 0.00059641 0.0 48517.0 34240.0 44915.0 42844.0 45643.0 28655.0 35355.0 29141.0 25761.0 30956.0 True False 45820.619368939304 36866.09790104738 42025.21779975445 37008.573289977605 39908.91828640283 32601.96614580891 36999.07755460343 29225.795485447732 30913.919822479846 30062.219846652795 1.524192810865931 1.2263265350696366 1.3979412702762748 1.2310658853124659 1.3275439568327951 1.0844829926768997 1.2307500159115163 0.9721768929416504 1.0283312403465734 1.0 14.875663923850741 -6.828724958534367 0.4909315279405606 0.9687577158450593 1.4218875637824484 0.708883237577935 0.09311282730326693 0.5650375918194986 0.2906295898423965 0.08096755588376384 0.10382325462947153 1.483457270670549e-07 6.828724958534367 0.4531298479373891 GQT(ph)PEAGADKR ddPTM_A459_Selumetinib_30min_R1 1 GQTPEAGADKR 11 1 Q07617 Q07617 SPAG1 Sperm-associated antigen 1 1 GQT(1)PEAGADKR 100.11 0.020699 2834100.0 1616.2 1904.0 1586.1 1452.2 1601.2 1418.4 1506.1 1575.8 1076.2 1544.6 True False 1653.8543154222439 1681.0787948544134 1370.7163318236596 1198.6005311701479 1456.37174271482 1404.1321838041576 1392.493664431933 1534.0046650802203 1826.2327974619375 1742.864455678088 0.9489288223385028 0.964549359749473 0.7864732838850406 0.6877187306593008 0.8356196249054814 0.805646233262505 0.7989684222977409 0.8801629180528513 1.0478340937599842 1.0 10.76724465864383 -8.137703830355285 3.8728172883910577 1.023075278310024 0.829812497187574 0.4953848338620567 0.0758649965477173 0.2164375212839379 5.437858069070961 0.06473228049627996 0.021965727575161444 7.282762874726107e-09 8.137703830355285 -0.1932627811224501 GQTNGDS(ph)SLEVLATR ddPTM_A459_Selumetinib_30min_R1 1 GQTNGDSSLEVLATR 15 0 A0A087WXJ0 A0A087WXJ0 PDLIM2 1 GQT(0.001)NGDS(0.904)S(0.082)LEVLAT(0.013)R 90.498 0.015504 3551800.0 2132.0 2528.2 1703.7 2227.4 6209.7 1804.4 4807.0 2455.9 377.18 579.59 True False 2181.6714518501567 2232.197168671708 1472.346897754222 1838.4264034763705 5648.033731411581 1786.2493742641173 4444.404119862097 2390.761554112523 640.046911862752 653.9860221846836 3.3359603689420436 3.4132184679038025 2.251343068213828 2.8111096279015038 8.63632178642588 2.7313265324800566 6.7958702007349805 3.655676838667018 0.9786859201128381 1.0 9.353115990726918 GQTPLTEGS(ph)EDLDGHSDPEESFAR ddPTM_A459_Selumetinib_30min_R2 1 GQTPLTEGSEDLDGHSDPEESFAR 24 0 K7EQI9;Q86VR2-2;Q86VR2 K7EQI9 FAM134C Protein FAM134C 1 GQTPLT(0.007)EGS(0.844)EDLDGHS(0.149)DPEESFAR 104.3 6.070000000000001e-07 17801000.0 11781.0 5379.4 13066.0 13780.0 11142.0 9690.2 12952.0 12835.0 9453.8 11318.0 True False 11126.259183079623 5791.982682502751 12225.34778518516 11903.140228174096 9742.242349256192 11024.937091122589 13554.293663901119 12872.34772505137 11344.824161242184 10991.219932304442 1.0122861021439744 0.5269644969508305 1.1122830641622843 1.082968069193977 0.8863658819729953 1.0030676448133886 1.2331928345882255 1.171148225977908 1.0321715179129898 1.0 13.4240639016519 -5.289467940383512 24.917851571498026 1.0692976787904425 0.7696252189774688 0.4097775977374929 0.14179892004802053 561.2823457435023 498988.28573374805 0.03673646340766344 0.076498420334323 5.134900819391849e-06 5.289467940383512 -0.29967245981297363 GQTPLTEGSEDLDGHS(ph)DPEESFAR ddPTM_A459_Selumetinib_30min_R1 2 GQTPLTEGSEDLDGHSDPEESFAR 24 0 K7EQI9;Q86VR2-2;Q86VR2 K7EQI9 FAM134C Protein FAM134C 1 GQTPLTEGSEDLDGHS(0.988)DPEES(0.012)FAR;GQTPLTEGS(0.013)EDLDGHS(0.98)DPEES(0.007)FAR 150.44 6.915e-10 34011000.0 2532.7 3148.1000000000004 2976.1000000000004 2918.0 3093.1 3432.8 3278.5 3276.7 1462.63 2409.8 True False 2591.706982223682 2779.518988488017 2571.9619665471246 2408.426077643913 2813.3296511311587 3398.269148733019 3031.200105464507 3189.7912717783693 2481.9762837314192 2719.121303439763 0.953141361860209 1.0222122069257629 0.9458798190774065 0.8857369013280827 1.0346466145413298 1.2497673952368786 1.114771930781446 1.1730963483472385 0.9127861565394862 1.0 11.408924797910512 -6.521582809792779 24.998619252812503 1.1068637698947421 0.9568366401122281 0.3298063130763177 0.09133431420598424 52.793087219244384 1018411.6581880257 0.0295891734294694 0.029980749812777457 3.008965374900025e-07 6.521582809792779 -0.15002712978251398 GQTPLTEGSEDLDGHS(ph)DPEESFAR ddPTM_A459_Selumetinib_30min_R2 2 GQTPLTEGSEDLDGHSDPEESFAR 24 0 K7EQI9;Q86VR2-2;Q86VR2 K7EQI9 FAM134C Protein FAM134C 1 GQTPLT(0.002)EGS(0.06)EDLDGHS(0.906)DPEES(0.032)FAR;GQTPLTEGSEDLDGHS(0.991)DPEES(0.009)FAR 161.31 4.6011e-13 21459400.0 15257.599999999999 8135.7 17401.9 20310.7 17696.8 11167.2 17127.1 18577.199999999997 14462.2 14189.6 True False 14409.643673012102 8759.682029601376 16282.280699756144 17544.347622088233 15473.56977260069 12705.380434251518 17923.544086704816 18631.256576378975 17355.044107630445 13779.909378991626 1.0456994510414233 0.6356850243845641 1.1815956296911174 1.2731830913805384 1.1229079485958855 0.9220220601466147 1.3007011580228847 1.3520594413184999 1.2594454455621709 1.0 13.750278780007527 -5.287471487307064 23.461243807634965 1.1859507202172657 0.8406923223650742 0.42207183971180084 0.156861731716188 276.3249952210647 249035.57661809816 0.041551318121361175 0.08656020749175554 5.158560314059112e-06 5.287471487307064 -0.3452583978521915 GQVSES(ph)EDSITK ddPTM_A459_Selumetinib_30min_R1 2 GQVSESEDSITK 12 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 GQVS(0.002)ES(0.994)EDS(0.004)ITK;GQVS(0.004)ES(0.994)EDS(0.002)ITK 188.48 0.00012235 11639300.0 3028.7 3135.6 3604.2 4011.4 3398.6 3399.9 3247.27 3397.7000000000003 2236.2 2671.46 True False 3099.262817175688 2768.482494299109 3114.769436453462 3310.884293303905 3091.1972300715647 3365.700092862207 3002.3258095079245 3307.5819587149804 3794.668074414036 3014.3679132239954 1.0281634181346144 0.9184288626991449 1.0333076539161017 1.098367680593698 1.025487703909838 1.1165525210432745 0.9960050982286395 1.0972721492305761 1.2588602929877515 1.0 11.55763979787862 -5.516396968389138 4.919073720729375 1.0831756567415562 0.9727284197876065 0.26054628428668447 0.07505626732457299 0.23550360411148927 16.178228328097795 0.020099299371606684 0.03929403897909643 3.0451103234204737e-06 5.516396968389138 -0.11044723695394976 GQVSES(ph)EDSITK ddPTM_A459_Selumetinib_30min_R2 1 GQVSESEDSITK 12 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 GQVS(0.005)ES(0.769)EDS(0.226)ITK 155.14 0.00042332 7856800.0 28655.0 23063.0 34157.0 37126.0 29847.0 28825.0 31801.0 28288.0 26598.0 24769.0 True False 27062.469815053606 24831.857940766808 31959.375807329678 32069.374754077788 26097.353024434513 32795.38210270256 33279.809512486034 28370.313396669502 31918.34321021383 24053.854612409323 1.125078298307006 1.032344226773372 1.3286592241578576 1.3332322519956232 1.084955132761589 1.3634148302278133 1.3835541142464984 1.1794497744254815 1.326953360470851 1.0 14.553980482883984 -5.257616453610519 24.79672503582513 1.2623307925104859 1.078711252008277 0.23375013136795908 0.12245990382838907 366.07485120211174 2374450.183098971 0.030009781635253956 0.0734835827291741 5.525652208369033e-06 5.257616453610519 -0.18361954050220874 GQVSESEDS(ph)ITK ddPTM_A459_Selumetinib_30min_R1 3 GQVSESEDSITK 12 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 GQVSES(0.003)EDS(0.996)ITK;GQVSES(0.001)EDS(0.974)IT(0.025)K;GQVS(0.08)ES(0.08)EDS(0.839)ITK 173.06 0.00019935 24563100.0 4855.7 5387.3 5621.5 5301.4 5650.8 4796.2 5486.1 5299.4 2958.27 4285.3 True False 4968.828362452536 4756.552411512176 4858.131176689177 4375.610009602962 5139.686137729773 4747.954582601173 5072.279060115551 5158.842697122806 5019.968126507827 4835.359997356797 1.027602570474318 0.9837018162271888 1.0047093038253259 0.9049191811974387 1.0629376386741283 0.9819237006544697 1.0489971921197725 1.0668994035486163 1.0381787766064872 1.0 12.239407588442225 -6.857188309929552 1.5016223843821284 1.0415582707060271 0.9867908076516461 0.19158829198827243 0.041471602013350345 0.5743331287123369 2.6800295446371094 0.019043301809294377 0.015932560960832384 1.3893500789001716e-07 6.857188309929552 -0.05476746305438107 GQVSESEDS(ph)ITK ddPTM_A459_Selumetinib_30min_R2 4 GQVSESEDSITK 12 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 GQVS(0.317)ES(0.185)EDS(0.483)IT(0.014)K;GQVSES(0.027)EDS(0.885)IT(0.088)K;GQVSES(0.003)EDS(0.996)IT(0.001)K;GQVSES(0.015)EDS(0.82)IT(0.165)K 167.37 0.00043103 61757200.0 200198.0 156793.0 174257.0 213309.0 187217.0 178225.0 190582.0 188687.0 156391.0 168889.0 True False 189071.79661609142 168818.5189310434 163045.49433667597 184255.94622145075 163697.1267187845 202773.87598453305 199444.44063106854 189236.04793118543 187673.56992963966 164012.7357436793 1.1527872866627544 1.0293012805717392 0.9941026445134422 1.123424625447427 0.9980757041612425 1.2363300634252576 1.216030204768746 1.1537887413019277 1.144262176218667 1.0 17.323448320261015 -6.757219302997019 24.99999996449065 1.1638157807142433 1.0577724025892492 0.2550293806449122 0.07554427453099717 128.79839495036572 763009.7785076406 0.024528966904719215 0.02369780867246473 1.7489633024285328e-07 6.757219302997019 -0.10604337812499409 GQVSESEDSIT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GQVSESEDSITK 12 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 GQVSESEDS(0.116)IT(0.884)K 175.6 0.00024194 22515000.0 89449.0 69951.0 79186.0 79108.0 78403.0 66923.0 80989.0 84110.0 67802.0 66018.0 True False 84477.78267271786 75316.01677208408 74091.25897119813 68333.35393108818 68553.3142082869 76141.0357834922 84755.14897665894 84354.74617483992 81364.29454616574 64111.88880463638 1.317661735565786 1.1747589749163256 1.155655532111543 1.0658452777661187 1.069276159016069 1.187627399584364 1.3219880205826926 1.3157426453600232 1.269098385076462 1.0 15.968304292229357 -7.010263800982738 23.703922134138338 1.2532746765552956 1.1501378173274026 0.06390110989663211 0.10740901828065724 463.9922354836148 1071575.9804089677 0.0391681486016959 0.032488689160701245 9.766438036547912e-08 7.010263800982738 -0.10313685922789295 GQVVENNS(ph)VTEFSEEK ddPTM_A459_Selumetinib_30min_R2 1 GQVVENNSVTEFSEEK 16 0 Q9BVS4-2;Q9BVS4;H0Y919 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 GQVVENNS(0.861)VT(0.139)EFSEEK 130.38 0.00059836 0.0 9617.7 8292.5 7663.7 7592.8 8912.3 8404.5 8796.3 10057.0 6081.2 8469.5 True False 9083.186736703587 8928.50808540991 7170.625885605657 6558.647541689428 7792.657197027101 9562.143586545139 9205.345379537783 10086.264204974017 7297.609922924751 8224.963528596265 1.1043437098685582 1.0855377114278484 0.8718124841131606 0.7974074923112489 0.9474397266241805 1.1625758039290768 1.1191958903565906 1.226298958032634 0.8872513413041501 1.0 13.00579356627836 -6.745583371326131 24.85404936599494 1.0957162974149988 0.9541322395002327 0.18455490089085436 0.12079215219038925 348.8288744100868 546782.7728386186 0.041993841556387114 0.0418573925645846 1.7964561821438725e-07 6.745583371326131 -0.14158405791476603 GRAEGEWEDQEALDY(ph)FSDKESGK ddPTM_A459_Selumetinib_30min_R2 1 GRAEGEWEDQEALDYFSDKESGK 23 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 GRAEGEWEDQEALDY(0.436)FS(0.367)DKES(0.198)GK 55.209 0.028868 18954000.0 101740.0 104280.0 101880.0 95915.0 84063.0 63985.0 81406.0 67141.0 53586.0 84882.0 True False 96085.69809748922 112277.94068695145 95325.15171855708 82851.21153739635 73502.25440724492 72798.3529520009 85191.54030292886 67336.36919420915 64304.69731793815 82431.23611007836 1.1656466969532853 1.362080031615878 1.1564202627176454 1.005094857812846 0.8916796335443798 0.8831403772082983 1.0334861433979274 0.8168792847445405 0.7801010921644546 1.0 16.33090350872763 -5.778224992241659 2.1202439756742653 0.8981731704270041 1.266135731915454 0.7541696689845252 0.08451245034907252 0.14546965535163886 1.3350661438017652 0.025749040478174553 0.0488995647373029 1.6663836958528028e-06 5.778224992241659 0.36796256148844997 GRAEGEWEDQEALDYFS(ph)DKESGK ddPTM_A459_Selumetinib_30min_R1 3 GRAEGEWEDQEALDYFSDKESGK 23 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 GRAEGEWEDQEALDY(0.332)FS(0.629)DKES(0.038)GK;GRAEGEWEDQEALDY(0.162)FS(0.792)DKES(0.046)GK;GRAEGEWEDQEALDY(0.437)FS(0.556)DKES(0.007)GK 99.343 2.1155e-05 360752000.0 29963.0 34751.0 44260.0 45087.0 31109.9 34074.5 30936.0 29567.2 20803.6 27480.9 True False 30661.07960215114 30682.33676469841 38249.7351027774 37213.401837810496 28296.01503789895 33731.74146717062 28602.47261328352 28782.981808198943 35302.189765172996 31008.341201634055 0.9888010262392039 0.9894865567037019 1.2335305153557115 1.2001094026870889 0.9125291434940682 1.0878279895021619 0.9224122124848216 0.928233523394091 1.1384739846487715 1.0 14.92036873026019 -6.265638831978435 24.99847708208498 0.9953452178125018 1.104199968184567 0.21115433124599303 0.099067342253882 601.2737548182646 3579254.628019787 0.03174877012675568 0.03732771442026255 5.424518167113709e-07 6.265638831978435 0.10885475037206505 GRAEGEWEDQEALDYFS(ph)DKESGK ddPTM_A459_Selumetinib_30min_R2 2 GRAEGEWEDQEALDYFSDKESGK 23 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 GRAEGEWEDQEALDY(0.058)FS(0.935)DKES(0.006)GK;GRAEGEWEDQEALDY(0.001)FS(0.992)DKES(0.007)GK 101.71 4.4718e-05 24266400.0 115320.0 109901.0 105767.0 102346.0 89699.0 75299.0 86517.0 75727.0 55641.0 97938.0 True False 108910.9760625365 118330.05331258768 98962.06637040262 88406.29824330228 78430.20970076573 85670.75375373467 90540.21193018308 75947.35303272023 66770.75473943556 95110.2754665162 1.145102098888136 1.2441353232569077 1.0404981573756713 0.9295136388751805 0.8246239359108708 0.9007518202793477 0.9519498443894001 0.7985189051361509 0.7020351314505693 1.0 16.537313594071293 -5.624318660604714 2.0344352666650325 0.8601003129917084 1.1972757683696482 0.715290069869227 0.08234015028679809 0.17045327366439916 1.4156827491719794 0.02484536779106439 0.056423006393990664 2.3750969359905935e-06 5.624318660604714 0.3371754553779398 GRAS(ph)PGGVSTSSSDGK ddPTM_A459_Selumetinib_30min_R1 2 GRASPGGVSTSSSDGK 16 1 P54259 P54259 ATN1 Atrophin-1 1 GRAS(0.995)PGGVS(0.001)T(0.004)SSSDGK;GRAS(0.987)PGGVS(0.002)T(0.004)S(0.004)S(0.004)SDGK 147.37 0.001516 41410500.0 3683.8999999999996 3913.9 3204.5 3700.3 3886.6000000000004 3553.25 4193.4 3494.0 1705.19 3312.0 True False 3769.727702378421 3455.658768477254 2769.3465010585223 3054.1120682336445 3535.0577162349628 3517.5075310928682 3877.0884618742925 3401.3277698884945 2893.582887849956 3737.127461611953 1.008723341952165 0.9246831433966419 0.7410361379175456 0.8172351892210548 0.9459291267283052 0.9412329569234561 1.0374514922758267 0.9101449722620334 0.7742799563496432 1.0 11.867714054990193 -6.285643206461786 23.801962315347456 0.9357972559836891 0.8671966143971555 0.09838050704691326 0.09114866163107034 1040.7589859875886 1023475.1636894358 0.0302097599354619 0.03427634392202531 5.180322452649048e-07 6.285643206461786 -0.06860064158653367 GRAS(ph)PGGVSTSSSDGK ddPTM_A459_Selumetinib_30min_R2 4 GRASPGGVSTSSSDGK 16 1 P54259 P54259 ATN1 Atrophin-1 1 GRAS(1)PGGVSTSSSDGK;GRAS(0.698)PGGVS(0.141)T(0.141)S(0.015)S(0.005)SDGK;GRAS(1)PGGVSTSSSDGK;GRAS(1)PGGVSTSSSDGK 140.46 0.0018963 103479700.0 97501.0 88304.0 101390.0 105587.0 113072.0 78082.4 87870.0 92352.0 68091.8 99275.0 True False 92082.28474742777 95076.63285788782 94866.67778508538 91205.86845226533 98866.88448349452 88837.54183854505 91956.12911110173 92620.72903030335 81712.06264385454 96408.6728025734 0.9551244931666546 0.9861834012857603 0.9840056400252939 0.9460338556784987 1.025497827212652 0.9214683622962782 0.9538159424661967 0.960709512306771 0.847559252383707 1.0 16.55687531486833 -6.797924640709448 24.99997744644573 0.93532402652284 0.9781533580182776 0.21082062449980699 0.04119007414563136 273.6861488485164 187529.9687427367 0.013835783893185538 0.012202359249973692 1.592485032958541e-07 6.797924640709448 0.04282933149543766 GRAS(ph)PGGVSTSSSDGKAEK ddPTM_A459_Selumetinib_30min_R1 3 GRASPGGVSTSSSDGKAEK 19 2 P54259 P54259 ATN1 Atrophin-1 1 GRAS(1)PGGVSTSSSDGKAEK;GRAS(0.985)PGGVS(0.013)T(0.002)SSSDGKAEK;GRAS(0.998)PGGVS(0.001)TSSSDGKAEK 108.34 0.00029075 11757200.0 3291.7400000000002 2879.86 7644.2 7775.099999999999 5295.2 4435.03 4074.5299999999997 3357.1 2917.63 2720.8999999999996 True False 3368.431137388947 2542.6846523894073 6606.159626584975 6417.32474170294 4816.250094943492 4390.417624885052 3767.1849216770784 3268.058802602364 4951.005014735992 3070.1540188103786 1.0971537964385722 0.8281944934393374 2.151735576166542 2.0902289274039485 1.5687324041188295 1.4300317176225081 1.2270345066065398 1.064460865018319 1.6126243127875401 1.0 11.584095317000308 -7.061622180292273 3.0918263867415003 1.2324788535112492 1.5685085911624954 0.12341467923547011 0.4012611416667065 0.6364479691857887 11.98657645500052 0.18037829417424797 0.14043793436327032 8.677164278370922e-08 7.061622180292273 0.3360297376512462 GRAS(ph)PGGVSTSSSDGKAEK ddPTM_A459_Selumetinib_30min_R2 2 GRASPGGVSTSSSDGKAEK 19 2 P54259 P54259 ATN1 Atrophin-1 1 GRAS(0.999)PGGVS(0.001)TSSSDGKAEK;GRAS(1)PGGVSTSSSDGKAEK 94.387 0.00071296 5152900.0 19955.4 33695.0 27499.0 27591.0 22798.3 14457.7 7334.3 10290.1 7282.200000000001 22413.2 True False 18846.358755795536 36279.298153498545 25729.7442786474 23833.05820287022 19934.173734612046 16449.11694106653 7675.359482639742 10320.042487382245 8738.843481668517 21766.072679512807 0.8658594057500583 1.6667820000273283 1.1821032051806653 1.0949636415256 0.9158369554363831 0.7557227793578568 0.3526295071992538 0.4741343392230757 0.4014892172024172 1.0 14.409793500584046 -6.538967265880564 1.3549189746970338 0.5171381247205188 1.2694965580288038 0.5690472020054465 0.25073639268570747 0.270443017277859 1.027618914531777 0.10325393301672826 0.11357992910445074 2.8908977700674825e-07 6.538967265880564 0.752358433308285 GRAS(ph)SHSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 1 GRASSHSSQTQGGGSVTK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 GRAS(0.743)S(0.199)HS(0.055)S(0.003)QTQGGGSVTK 76.492 0.008004899999999999 1987000.0 532.03 714.18 1038.4 1006.8 1328.7 816.91 1130.6 822.16 451.2 602.89 True False 544.4252638498307 630.5634735867256 897.3909835229116 830.9812799766587 1208.5193196010384 808.692627094934 1045.3179317487184 800.3536460479463 765.6534456558508 680.2768041459035 0.8002996141157036 0.9269219084699006 1.3191556408418157 1.221534050422264 1.7765111381658094 1.1887699568269983 1.5366067538656252 1.1765117392953017 1.1255027967874618 1.0 9.409978087183559 -5.180745337822944 2.9748853856120943 1.3223293165980337 0.8135308351938771 0.3978234317204268 0.21114839488398876 0.24967067671162121 4.1969854852526245 0.05521130131478033 0.1893750870146412 6.5956053585979665e-06 5.180745337822944 -0.5087984814041565 GRAS(ph)SHSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 1 GRASSHSSQTQGGGSVTK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 GRAS(0.497)S(0.497)HS(0.006)S(0.001)QTQGGGSVTK 54.62600000000001 0.038791 2472500.0 830.68 552.67 1038.6 916.94 3211.8 818.11 0.0 751.69 2094.8 1201.6 True False 784.5141310755098 595.05801188586 971.777606742179 792.051190190273 2808.3049701436944 930.7972264368427 0.0 753.8772934510218 2513.8185336023757 1166.906685868264 0.6723023705119778 0.509944813147671 0.832780905714929 0.6787613780796268 2.406623429408248 0.7976620904732081 0.0 0.6460476253849569 2.1542584030460934 1.0 10.188473482196041 -6.071511695209537 24.999999993398774 1.1155842776403535 0.6721357093400233 0.11513832649899414 0.6616015607341893 413.1395028971359 144428.97937958976 0.20758403115392027 0.2679899566953916 8.481805413085844e-07 6.071511695209537 -0.4434485683003302 GRASS(ph)HSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R1 1 GRASSHSSQTQGGGSVTK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 GRAS(0.388)S(0.612)HSSQTQGGGSVTK 100.04 0.0015852 2718100.0 634.33 670.54 739.2 911.87 1239.3 695.3 1093.4 681.65 395.91 596.9 True False 649.1086548086816 592.0328650744111 638.8207001349533 752.6290224198611 1127.2055338161858 688.3059132818892 1010.92395769861 663.57042768875 671.8303538776764 673.5179292983627 0.9637585379276994 0.8790157460116338 0.9484835849885166 1.1174595206454452 1.673608800571133 1.0219563330688641 1.50096072238454 0.9852305318434871 0.9974943867902013 1.0 9.39557254105331 -5.836826439981606 4.2823456294704085 1.2166695403142374 0.9234412584590465 0.22080365483058872 0.21969838366625627 0.2960150356034463 10.309069687253114 0.06281925012742788 0.09819123020361277 1.4560408517028669e-06 5.836826439981606 -0.2932282818551909 GRASS(ph)HSSQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 1 GRASSHSSQTQGGGSVTK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 GRAS(0.121)S(0.752)HS(0.121)S(0.006)QTQGGGSVTK 82.34899999999998 0.0053178 1471500.0 722.05 434.82 869.31 1650.8 2135.8 1122.8 400.5 611.42 578.79 2078.1 True False 681.9213515951652 468.1692958333359 813.379541033164 1425.958192211162 1867.4817097057414 1277.455508236407 419.12404357569466 613.1991309739703 694.5641727438026 2018.0998534477694 0.33790268129208506 0.23198519886590568 0.40304226752881783 0.7065845576347579 0.9253663571281131 0.6329991581209284 0.20768251028790932 0.3038497475367071 0.34416739665145546 1.0 10.978781843898197 -5.542630295578748 7.130492772743662 0.5598092055894608 0.2921934766023219 0.20112733849617448 0.2441461597887439 0.2881623438597143 64.13155721320648 0.07223453978907125 0.129218693257915 2.8666172136420936e-06 5.542630295578748 -0.26761572898713887 GRASSHS(ph)SQTQGGGSVTK ddPTM_A459_Selumetinib_30min_R2 1 GRASSHSSQTQGGGSVTK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 GRAS(0.12)S(0.192)HS(0.567)S(0.118)QT(0.003)QGGGSVTK 81.89 0.0055281 1493000.0 764.21 0.0 504.78 1058.2 2399.1 878.45 807.09 1017.4 559.88 2195.2 True False 721.7382675750173 0.0 472.3030043629087 914.0713345031808 2097.7036097738746 999.4485137248588 844.6212842184951 1020.3604655603635 671.8716443542567 2131.8188721854312 0.338555154470102 0.0 0.22154931196322883 0.4287753272238001 0.9839971102345185 0.468824310904179 0.396197489026182 0.47863375208529907 0.31516356906320486 1.0 11.057869150854582 -5.832474996792212 3.7266381264780684 0.5731045936292469 0.16241392671910332 0.39201039142442784 0.23074527769077788 0.23895640044688718 6.554192518476261 0.06657616346310677 0.10647051405056865 1.470703084305126e-06 5.832474996792212 -0.4106906669101436 GRDS(ph)PYQSR ddPTM_A459_Selumetinib_30min_R2 3 GRDSPYQSR 9 1 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 GRDS(1)PYQSR;GRDS(0.996)PYQS(0.003)R;GRDS(1)PYQSR 77.387 0.029774 3049810000.0 46359.0 36295.6 36934.4 49109.0 54381.0 33886.1 46983.9 55320.0 58852.0 34629.9 True False 43782.55236978086 39079.355811251604 34558.08091513417 42420.26948224976 47549.172607691675 38553.60268761108 49168.744446831646 55480.97204128099 70624.04446227168 33630.04480771422 1.301888017697134 1.1620369831409618 1.0275954466527226 1.2613801059378664 1.413889659664819 1.1464035480192838 1.4620481396311753 1.6497442200420291 2.100028259435194 1.0 15.037463080621023 -7.500174274960672 3.1492511838654065 1.6520542987053008 1.2188800874811296 0.2674193010294459 0.2682640956753499 0.2867484338581041 5.805575230934832 0.12867321381528218 0.07466309324496073 3.1610089467079684e-08 7.500174274960672 -0.4331742112241712 GRDVESVQT(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 GRDVESVQTPSK 12 1 P46013 P46013 MKI67 Antigen KI-67 1 GRDVESVQT(0.999)PSK;GRDVESVQT(0.994)PS(0.006)K 158.31 0.0046929 9290500.0 2265.0 3770.0 3772.5 4921.6 3637.1 2976.9 3466.6 2556.5 1687.9 2483.6 True False 2317.770093077207 3328.6066473745504 3260.21522085919 4062.1349498739846 3308.1249471821593 2946.955088808938 3205.111571024329 2488.693315317669 2864.24302066159 2802.3942523126366 0.8270678157309592 1.1877724358832324 1.163367794580917 1.4495230093059763 1.18046379250606 1.0515847605585846 1.1437047333291366 0.8880596701423827 1.0220699740223609 1.0 11.452444218962174 -7.448883696758965 1.724320940765958 0.9703696851256066 1.1694195764199806 0.19045300756572225 0.15038233968753936 0.5902700403484793 3.4179470093477593 0.09552200080091043 0.050106342667388386 3.5572656871696144e-08 7.448883696758965 0.199049891294374 GRECS(ph)PTSSLER ddPTM_A459_Selumetinib_30min_R1 2 GRECSPTSSLER 12 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 GRECS(0.906)PT(0.094)SSLER;GRECS(0.694)PT(0.303)S(0.003)SLER 199.13 0.0005479 84843000.0 5711.5 6626.1 8136.0 8605.7 7968.7 5886.7 6146.8 6514.4 3368.3 4904.6 True False 5844.566837355614 5850.313131609683 7031.175887849002 7102.876043995965 7247.932491988254 5827.4851426959485 5683.14192718293 6341.616950246595 5715.759089101511 5534.153184849634 1.056090542154809 1.0571288752226036 1.2705061918231022 1.2834621317387611 1.3096732688625756 1.0530039462314384 1.0269216874482565 1.1459055682823314 1.0328154820052764 1.0 12.434146862828289 -6.79737866107754 24.996811895230955 1.0592978230290229 1.1967600455197482 0.39731793227687906 0.08820215910229046 216.0914203849202 150296.4050093327 0.03454221271929265 0.0304643584380368 1.594488307665853e-07 6.79737866107754 0.13746222249072537 GREDVSNFDDEFTSEAPILT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 GREDVSNFDDEFTSEAPILTPPR 23 1 Q16513-3;Q16513-2;Q16513;Q16513-4;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 GREDVSNFDDEFTSEAPILT(1)PPR 73.60300000000002 0.0016668 2811400.0 11732.0 7384.7 10832.0 12514.0 13238.0 11612.0 11681.0 13880.0 13212.0 10358.0 True False 11079.98240691708 7951.082744446978 10135.080912989873 10809.571612145908 11574.92409077844 13211.447596759133 12224.189645462393 13920.388502042311 15854.769174123821 10058.937626683997 1.1015062244271694 0.7904495523816177 1.0075697145296822 1.074623584847634 1.150710395109011 1.3134038689843615 1.2152565309714707 1.3838825747477341 1.5761872438760178 1.0 13.296190322699982 -6.354552072968806 1.13524967169104 1.331838585310431 0.9402254970784818 0.4658664362650412 0.1543626232149395 0.38936708790829394 1.0467914448031157 0.06590924131195491 0.08908401982122927 4.42026113687755e-07 6.354552072968806 -0.3916130882319493 GREDVSNFDDEFTSEAPILT(ph)PPREPR ddPTM_A459_Selumetinib_30min_R1 4 GREDVSNFDDEFTSEAPILTPPREPR 26 2 Q16513-3;Q16513-2;Q16513;Q16513-4;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 GREDVSNFDDEFTSEAPILT(1)PPREPR;GREDVSNFDDEFTSEAPILT(1)PPREPR;GREDVSNFDDEFTSEAPILT(1)PPREPR;GREDVSNFDDEFTSEAPILT(0.999)PPREPR 161.96 9.744e-14 446814000.0 8514.8 9748.400000000001 10416.900000000001 10692.3 10114.5 8459.5 10498.4 8468.4 4912.58 8362.4 True False 8713.178273083357 8607.052796091792 9002.342195935873 8825.09052432899 9199.645260860018 8374.40511061145 9706.497235689665 8243.790522760075 8336.289459352874 9435.795496673854 0.9234174560220998 0.9121703410301552 0.9540628767451801 0.935277849910997 0.9749729383286146 0.8875144775619026 1.028688809450272 0.8736720211524334 0.8834750034897896 1.0 13.203928435845267 -5.246110596081881 23.697768277888876 0.9397542158159059 0.9177938954693693 0.03736210938009521 0.048301652436377115 1782.9712262214143 2756382.256152433 0.011945851521324479 0.03131445984452458 5.6740009466580074e-06 5.246110596081881 -0.02196032034653661 GREDVSNFDDEFTSEAPILT(ph)PPREPR ddPTM_A459_Selumetinib_30min_R2 4 GREDVSNFDDEFTSEAPILTPPREPR 26 2 Q16513-3;Q16513-2;Q16513;Q16513-4;Q16513-5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 GREDVSNFDDEFTSEAPILT(1)PPREPR;GREDVSNFDDEFTSEAPILT(1)PPREPR;GREDVSNFDDEFT(0.001)SEAPILT(0.999)PPREPR;GREDVSNFDDEFT(0.004)S(0.004)EAPILT(0.991)PPREPR 122.65 2.4989e-08 165172000.0 66825.4 59964.0 85685.6 73371.5 81890.8 60979.1 53982.7 63461.8 57046.5 65396.2 True False 63111.51179127146 64563.04598535055 80172.68178342722 63378.175127102724 71602.94559095934 69378.41751184427 56493.002514690736 63646.46333133344 68457.39401238685 63508.04178626684 0.9937562238758695 1.0166121355565374 1.262402044346516 0.9979551147301758 1.1274626579093006 1.0924351556190928 0.8895409293962351 1.0021795908230402 1.0779326851672866 1.0 15.954651666089164 -7.145812705233688 21.820126291818468 0.9923270329561868 1.0852911404683792 0.2096229811721293 0.08483567044261442 12.523304165055887 2329.4474224652504 0.03253208050237761 0.025199226337606642 7.148045277409861e-08 7.145812705233688 0.0929641075121923 GREETVAEDVCIDLTCDSGSQAVPS(ph)PATR ddPTM_A459_Selumetinib_30min_R1 2 GREETVAEDVCIDLTCDSGSQAVPSPATR 29 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 GREETVAEDVCIDLTCDSGSQAVPS(0.984)PAT(0.016)R;GREETVAEDVCIDLTCDSGS(0.001)QAVPS(0.991)PAT(0.008)R 184.72 4.7686999999999997e-29 56123000.0 2927.67 3833.5 3881.48 3697.85 3938.1 3126.86 3579.94 3121.55 1861.51 3302.37 True False 2995.8790147458467 3384.672037854202 3354.39633544348 3052.089914741448 3581.899550328025 3095.4066273617245 3309.9022435737697 3038.756353776595 3158.8465106888766 3726.2613573078124 0.8039905759348936 0.9083292107828943 0.9002042567049023 0.8190756423340506 0.9612582711900575 0.830700353664437 0.8882635774011144 0.8154973745513296 0.8477254298048252 1.0 11.863513152089316 GREETVAEDVCIDLTCDSGSQAVPS(ph)PATR ddPTM_A459_Selumetinib_30min_R2 1 GREETVAEDVCIDLTCDSGSQAVPSPATR 29 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 GREETVAEDVCIDLTCDS(0.017)GS(0.017)QAVPS(0.799)PAT(0.166)R 97.387 7.9909e-08 4068400.0 5086.9 4781.7 8850.6 8665.9 10438.0 6384.6 4483.1 6087.7 6082.5 6970.5 True False 4804.190462474128 5148.4410144111625 8281.16203180467 7485.589470488671 9126.685123096046 7264.020696371718 4691.573033094124 6105.414199127014 7299.169959249779 6769.243553465995 0.7097086143420385 0.7605637134706215 1.2233511715743395 1.1058236287946668 1.3482577559826445 1.0730919398892638 0.6930719800577925 0.9019344851317861 1.0782844348261704 1.0 12.724778909801014 -5.1487344194798235 6.6831718530060575 1.049326235290615 0.7244378220154447 0.3702250263174711 0.16611081101188738 0.2844194969346873 14.772249914882789 0.047616277077370296 0.12918481124226555 7.100118229029982e-06 5.1487344194798235 -0.32488841327517026 GRGPS(ph)PEGSSSTESSPEHPPK ddPTM_A459_Selumetinib_30min_R1 2 GRGPSPEGSSSTESSPEHPPK 21 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GRGPS(0.972)PEGS(0.01)S(0.002)S(0.013)T(0.002)ESSPEHPPK;GRGPS(0.964)PEGS(0.012)S(0.012)S(0.005)T(0.007)ESSPEHPPK 106.12 7.7878e-05 8126400.0 1586.08 2050.2799999999997 1676.47 2110.02 2570.5 1747.87 2366.7 1861.85 715.61 1382.77 True False 1623.0325780255603 1810.232264450687 1448.814582190537 1741.5446169808808 2337.998728858636 1730.2880147389835 2188.177913558899 1812.467689858871 1214.3379039135266 1560.2619988204 1.0402307940926694 1.160210442745687 0.9285713446112767 1.116187293094067 1.498465469662291 1.108972734096663 1.4024426123389664 1.1616431671277934 0.7782910208872603 1.0 10.607572591096796 -8.211444041391958 8.785063419787516 0.8896754844575693 1.1824767625800774 0.33059320465194086 0.16377108628465914 0.41476200163395194 70.16283337596036 0.11555722098111741 0.04320339174343027 6.145482108076389e-09 8.211444041391958 0.2928012781225081 GRGPS(ph)PEGSSSTESSPEHPPK ddPTM_A459_Selumetinib_30min_R2 1 GRGPSPEGSSSTESSPEHPPK 21 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GRGPS(0.988)PEGS(0.002)S(0.002)S(0.002)T(0.002)ES(0.002)S(0.002)PEHPPK 73.934 0.0018946 1906500.0 6252.6 6433.5 7560.5 9244.0 10200.0 7515.3 5716.0 6013.5 5324.3 9351.2 True False 5905.105523140961 6926.928763037037 7074.065661249993 7984.951253210555 8918.584810843038 8550.464357899064 5981.805326039124 6030.998289411484 6389.308773371742 9081.20655866455 0.6502556114095642 0.762776258671038 0.7789786098963353 0.8792830778187688 0.9820924954441929 0.9415559818690508 0.6587016039550132 0.6641186113817877 0.7035748754415879 1.0 13.148668276072494 -10.524835191721168 21.93092312051502 0.9999999999961995 0.7862211181381746 0.2518427372472333 0.11324505690944738 0.0 0.0 0.12381807424793952 0.030030294028519103 2.9865157420860357e-11 10.524835191721168 -0.21377888185802485 GRLDSSEMDHS(ph)ENEDYTMSSPLPGK ddPTM_A459_Selumetinib_30min_R1 2 GRLDSSEMDHSENEDYTMSSPLPGK 25 1 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 GRLDSS(0.003)EMDHS(0.995)ENEDY(0.001)T(0.001)MSSPLPGK;GRLDS(0.001)S(0.001)EMDHS(0.996)ENEDY(0.001)T(0.001)MSSPLPGK 90.299 2.7124e-05 20117400.0 4350.6 6097.799999999999 5325.1 6393.1 5696.6 5208.4 5498.8 4520.5 2398.3 3990.3 True False 4451.960515206044 5383.866741209691 4601.980668680521 5276.665098349996 5181.343535816419 5156.008224848829 5084.02108889072 4400.601655346575 4069.7399350984624 4502.493873813464 0.9887765847053512 1.1957521524953754 1.0220959312006337 1.1719427602198678 1.1507719235224614 1.1451449728418752 1.129156692129982 0.9773698262957125 0.9038857240357612 1.0 12.136508597834183 -7.815008773476672 4.859688012227871 0.9498316878674498 1.1193287899515139 0.5455571181871112 0.0645963439082385 0.1392583085373233 6.812349546717365 0.03426659327725433 0.016271181226835987 1.531056531460708e-08 7.815008773476672 0.1694971020840641 GRLDSSEMDHS(ph)ENEDYTMSSPLPGK ddPTM_A459_Selumetinib_30min_R2 2 GRLDSSEMDHSENEDYTMSSPLPGK 25 1 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 GRLDS(0.005)S(0.005)EMDHS(0.727)ENEDY(0.184)T(0.047)MS(0.014)S(0.018)PLPGK;GRLDSSEMDHS(0.997)ENEDY(0.001)T(0.001)MSSPLPGK 86.98700000000002 4.531300000000001e-05 16315000.0 58238.0 54203.0 78421.0 70380.0 83878.0 62459.0 55155.0 59863.0 53027.0 73044.0 True False 55001.365105185556 58360.195809885205 73375.47823832887 60794.12258772817 73340.49576116588 71062.16030364957 57719.81678755914 60037.191419146846 63633.881698173114 70935.02992889618 0.7753766391628761 0.8227274432446743 1.0344039935117944 0.8570395000702326 1.0339108312871776 1.0017922086574267 0.8136997594195181 0.8463687331819961 0.8970727405339564 1.0 16.114210630768106 -5.050524147081724 9.285376912345699 0.9288602753501771 0.7869833164019617 0.3405686108415329 0.07676361626077054 0.4730087994257711 85.23519865047501 0.020332641625862558 0.054663405867327736 8.901759422194397e-06 5.050524147081724 -0.1418769589482154 GRLPNNS(ph)SRPSTPTINVLESK ddPTM_A459_Selumetinib_30min_R2 1 GRLPNNSSRPSTPTINVLESK 21 2 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 GRLPNNS(0.299)S(0.299)RPS(0.299)T(0.084)PT(0.018)INVLESK 43.895 0.041713 13722000.0 47032.0 39469.0 46216.0 40312.0 48535.0 35861.0 35270.0 36359.0 26944.0 41658.0 True False 44418.1497240133 42496.14538716234 43242.51287617615 34821.43605792122 42437.599391594784 40800.527236253845 36910.12488617913 36464.79867044353 32333.552878261573 40455.225299517435 1.0979582833899861 1.0504488622306412 1.0688980856248491 0.8607401343118113 1.0490016821659127 1.008535410053458 0.9123697770290111 0.9013618982583814 0.7992429318802301 1.0 15.304038436390938 -5.22937521525405 0.432560033473714 0.9009159826584276 1.1855635888353593 0.40243416547217015 0.07339443513224658 3.770134381636455 0.7347019980746878 0.060395819856683144 0.5318637221644436 5.896913872758546e-06 5.22937521525405 0.28464760617693163 GRLPNNSS(ph)RPSTPTINVLESK ddPTM_A459_Selumetinib_30min_R1 1 GRLPNNSSRPSTPTINVLESK 21 2 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 GRLPNNS(0.167)S(0.662)RPS(0.167)T(0.005)PTINVLESK 77.062 0.0010512 14559000.0 2437.6 3308.5 3671.2 3071.3 3145.9 2722.6 3154.7 3248.4 1847.6 2564.8 True False 2494.39133725607 2921.1392819200796 3172.671204458118 2534.9551104413126 2861.3539004537547 2695.213115923012 2916.7384391364585 3162.2418797097266 3135.24225663508 2894.017063267616 0.8619131410509615 1.009371824028515 1.0962862813517331 0.8759295660748839 0.9887135555527854 0.9313051917115736 1.007851154769346 1.0926825276348786 1.083353065339255 1.0 11.498857712758054 -7.556056971422564 5.018431471186555 1.0648459898182632 0.9664404956066583 0.298005081823425 0.0670226152335383 0.24215751456079404 15.310581511239013 0.03219814559070768 0.018581876548513305 2.779348644585373e-08 7.556056971422564 -0.09840549421160483 GRLS(ph)GDEGSEDGDDYDTPPILK ddPTM_A459_Selumetinib_30min_R2 2 GRLSGDEGSEDGDDYDTPPILK 22 1 A0A087WXS2;E0YMJ8;A0A0C4DGS8;A0A087WZC2;P35680-3;P35680-4;P35680-2;P35680 A0A087WXS2 HNF1B Hepatocyte nuclear factor 1-beta 1 GRLS(0.899)GDEGS(0.1)EDGDDYDT(0.001)PPILK;GRLS(0.957)GDEGS(0.043)EDGDDYDTPPILK 69.28399999999999 0.0026084 5260900.0 23919.0 21657.8 25886.0 32086.0 35341.0 21971.0 19684.5 27154.0 21055.0 25445.0 True False 22589.677735343488 23318.88361919694 24220.522942545773 27715.831448562716 30901.147627451337 24997.305817119803 20599.86825409678 27233.013644413302 25266.588325853558 24710.33673595041 0.9141792755287859 0.9436894312035383 0.9801777774767424 1.1216290471768315 1.250535270225358 1.0116133213495182 0.8336538863967232 1.1020899446017147 1.0225108866725348 1.0 14.592827050433694 -5.549507551470627 6.442508660630451 1.0512969431149115 0.9363973727851649 0.19183536256494582 0.10009916804858598 0.29303268500545077 41.09482493853901 0.029833521103199125 0.05342481991325554 2.8215805212938922e-06 5.549507551470627 -0.11489957032974663 GRLS(ph)GIEER ddPTM_A459_Selumetinib_30min_R2 2 GRLSGIEER 9 1 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 GRLS(1)GIEER;GRLS(1)GIEER 100.38 0.0098828 4542600.0 21077.8 19356.3 24088.0 24030.3 24621.0 22360.9 20665.6 20412.3 18786.3 21342.0 True False 19906.38025711871 20840.86596968583 22538.204305031388 20757.331685420315 21527.889865467303 25440.911002960005 21626.591348109545 20471.696413561833 22544.08493307918 20725.801006824644 0.9604637355421819 1.0055517739856374 1.0874467190730024 1.0015213249700357 1.0387000173541445 1.2274995303960874 1.043462269129588 0.987739697337674 1.0877304537303918 1.0 14.339140239352139 -5.01645229118632 3.358613365719045 1.061406303300423 0.9633828807128303 0.19194456336251497 0.06535744673331845 0.40736709830476153 9.22513863668465 0.017578015822017345 0.07635945524876211 9.62825777044779e-06 5.01645229118632 -0.09802342258759278 GRLS(ph)PVPVPR ddPTM_A459_Selumetinib_30min_R1 4 GRLSPVPVPR 10 1 Q9UKM9-2;Q9UKM9;Q5QPM0;Q5QPM1;Q5QPL9 Q9UKM9-2 RALY RNA-binding protein Raly 1 GRLS(1)PVPVPR;GRLS(1)PVPVPR;GRLS(1)PVPVPR;GRLS(1)PVPVPR 108.72 0.0057798 1258364000.0 5622.8 5592.099999999999 7276.4 6881.4 6165.6 5298.900000000001 6028.8 6065.090000000001 3450.6800000000003 5254.4 True False 5753.8002999357695 4937.37433230324 6288.304846404186 5679.69266987622 5607.922568625094 5245.597877016254 5574.042762185272 5904.22411101116 5855.551932304369 5928.853422190172 0.9704743717226634 0.8327705174534961 1.0606274769534156 0.9579748840844323 0.945869659660683 0.8847575582461411 0.9401552653204522 0.9958458559479931 0.9876364813453721 1.0 12.53353741438131 -7.760474231589691 24.236126190539512 0.9938058895056934 0.9407649672661077 0.16047720572030388 0.05518378599883538 33.20076151675293 833829.3614972258 0.027804023203538957 0.014868856809550477 1.7359042578852404e-08 7.760474231589691 -0.053040922239585675 GRLS(ph)PVPVPR ddPTM_A459_Selumetinib_30min_R2 5 GRLSPVPVPR 10 1 Q9UKM9-2;Q9UKM9;Q5QPM0;Q5QPM1;Q5QPL9 Q9UKM9-2 RALY RNA-binding protein Raly 1 GRLS(1)PVPVPR;GRLS(1)PVPVPR;GRLS(1)PVPVPR;GRLS(1)PVPVPR;GRLS(1)PVPVPR 89.43 0.016967 3620031000.0 202753.0 161707.0 186111.0 201811.0 197506.0 158972.0 178592.0 190046.0 163545.0 156882.0 True False 191484.79994456685 174109.4069300428 174136.82088233577 174323.99365660665 172693.53055395733 180868.94999586564 186896.8818733343 190599.00239619118 196258.56982910127 152352.40903161207 1.2568544282410072 1.1428070487150375 1.1429869864821343 1.1442155379403 1.1335136191914406 1.1871748608736248 1.2267405751001579 1.251040292750758 1.2881881624095552 1.0 17.21705278687002 -6.9967398254444575 7.004529258559494 1.2117646957525685 1.1604932137084005 0.0010685443325560984 0.07959339045997371 0.35551786873993374 102.04725177977797 0.027634896287912488 0.023347124121508692 1.0075350762127273e-07 6.9967398254444575 -0.05127148204416798 GRLSGDEGS(ph)EDGDDYDTPPILK ddPTM_A459_Selumetinib_30min_R1 1 GRLSGDEGSEDGDDYDTPPILK 22 1 A0A087WXS2;E0YMJ8;A0A0C4DGS8;A0A087WZC2;P35680-3;P35680-4;P35680-2;P35680 A0A087WXS2 HNF1B Hepatocyte nuclear factor 1-beta 1 GRLS(0.008)GDEGS(0.992)EDGDDYDTPPILK 103.71 4.4801000000000014e-05 4061700.0 2865.1 2806.4 3560.3 4019.1 3528.1 2444.9 3000.5 2706.4 1660.4 2581.0 True False 2931.851255485872 2477.8253833400354 3076.830815328024 3317.239632850805 3208.983977936647 2420.3065257915873 2774.169869283591 2634.617480373845 2817.5775291821237 2912.296491068978 1.0067145513778772 0.8508149465340094 1.0564964194969904 1.1390459875990133 1.1018740666609697 0.8310646025271958 0.9525712364077716 0.9046529048307135 0.9674761954432438 1.0 11.507941523584838 -6.753818083816537 24.99899549150516 0.9265324318570147 1.02839972382097 0.26769592373832707 0.08232973495229484 265.1976594806541 869887.4309138826 0.029869756268657593 0.029321849620329493 1.7627142531175896e-07 6.753818083816537 0.10186729196395516 GRLT(ph)PSPDIIVLSDNEAS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 GRLTPSPDIIVLSDNEASSPR 21 1 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 2 GRLT(0.997)PS(0.003)PDIIVLS(0.211)DNEAS(0.513)S(0.276)PR 123.22 0.00024279 4694200.0 823.91 1048.6 1324.5 1134.8 1345.7 1016.9 993.54 988.52 529.15 947.65 True False 843.1054999502169 925.8294245190851 1144.6401749577187 936.6284828342403 1223.9816726026318 1006.6709092713253 918.5964778963574 962.3012384345086 897.9289024131057 1069.2901083926838 0.7884721773191571 0.8658355831148169 1.0704673745446858 0.8759348613466037 1.1446675350270232 0.9414385313865052 0.8590713321730402 0.8999440197581209 0.8397430176950185 1.0 10.062437607465752 -10.543985227261519 14.689389508674951 0.9999998187010226 0.9268844711060606 0.04749217943271389 0.10327447357681203 0.0 0.0 0.10250832924136065 0.024861921703983617 2.8576877473633056e-11 10.543985227261519 -0.07311534759496197 GRNDS(ph)GEENVPLDLTR ddPTM_A459_Selumetinib_30min_R1 5 GRNDSGEENVPLDLTR 16 1 Q6R327-3;Q6R327;Q6R327-4 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 GRNDS(1)GEENVPLDLTR;GRNDS(1)GEENVPLDLTR;GRNDS(1)GEENVPLDLTR;GRNDS(1)GEENVPLDLTR;GRNDS(1)GEENVPLDLTR 271.27 7.105e-50 73211100.0 6790.1 8981.7 7872.4 8045.8 8441.0 6980.300000000001 8298.4 7219.4 3897.6800000000003 6464.149999999999 True False 6948.296118765356 7930.118388520955 6803.371319997851 6640.75206837128 7677.513040379589 6910.084519605308 7672.4450069198265 7027.91806008385 6614.078284716079 7293.886618653051 0.9526191565682008 1.0872280860852475 0.9327498048295981 0.9104545238458362 1.0525956107880083 0.9473803036550876 1.0519007777415497 0.9635354136313244 0.9067975183219243 1.0 12.832472058235437 -7.990776271962462 24.9744111440749 0.9473213103600812 0.9910939040980201 0.06542274456659203 0.05868293401480515 459.8804879227298 1245184.1252438296 0.031348987307763476 0.015027443688280422 1.0214655590793644e-08 7.990776271962462 0.04377259373793896 GRNDS(ph)GEENVPLDLTR ddPTM_A459_Selumetinib_30min_R2 4 GRNDSGEENVPLDLTR 16 1 Q6R327-3;Q6R327;Q6R327-4 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 GRNDS(1)GEENVPLDLTR;GRNDS(0.999)GEENVPLDLT(0.001)R;GRNDS(1)GEENVPLDLTR;GRNDS(1)GEENVPLDLTR 150.13 0.00013151 44366200.0 71280.0 63562.0 83329.0 80063.0 92215.0 61288.0 64316.0 66348.0 61296.0 85849.0 True False 67318.54295644822 68437.00101595712 77967.70286175537 69158.28128362157 80630.12728744022 69729.86568292922 67306.82143973628 66541.06169549725 73556.91275333735 83370.31630751051 0.8074641663604166 0.8208797093143798 0.9351973977665186 0.8295312330174207 0.9671323182946417 0.836387203159112 0.8073235705556855 0.798138529906271 0.8822913959211031 1.0 16.347246188413628 -5.030025649727385 23.532972170370503 0.8720865078805272 0.8108179699560347 0.1360774621073375 0.06499374814495264 607.7433623566498 476329.94699326257 0.0163328672378547 0.043392169567110214 9.331991837910914e-06 5.030025649727385 -0.061268537924492494 GRNDS(ph)GEENVPLDLTREPSDNLR ddPTM_A459_Selumetinib_30min_R1 2 GRNDSGEENVPLDLTREPSDNLR 23 2 Q6R327-3;Q6R327;Q6R327-4 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 GRNDS(1)GEENVPLDLTREPSDNLR;GRNDS(1)GEENVPLDLTREPSDNLR 64.27 0.0018822 9864100.0 799.75 590.76 2040.06 1423.72 1284.9699999999998 900.77 859.05 840.65 522.16 472.58000000000004 True False 818.3826189573933 521.5935445631269 1763.0310572474477 1175.0940285343354 1168.744690379879 891.7090716337216 794.2511668748773 818.3532311839614 886.0673829425059 533.2402463190149 1.534735280404529 0.9781586220539695 3.306260300901409 2.203685930771487 2.191778843490874 1.6722463801058447 1.489480909135487 1.5346801687102507 1.6616663671939151 1.0 9.058641861750077 -6.936936722803634 3.8560283628910677 1.4752895727668602 2.061500619725101 0.20427604712214842 0.5750038146948182 0.42516997115939953 12.821955906444808 0.22693454666233162 0.19473068682409214 1.1562807013231728e-07 6.936936722803634 0.5862110469582409 GRNS(ph)ATSADEQPHIGNYR ddPTM_A459_Selumetinib_30min_R1 1 GRNSATSADEQPHIGNYR 18 1 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10;F5H4F6;F5H6N2;F5H4J8 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 GRNS(0.886)AT(0.104)S(0.01)ADEQPHIGNYR 97.291 0.0019528 4970600.0 544.29 509.34 768.57 1053.7 1002.6 613.95 753.7 671.72 518.69 752.36 True False 556.9708979960235 449.70623601425825 664.2024154528158 869.6910753986944 911.915007023407 607.7742204219984 696.8478021926486 653.9038035459351 880.1790463812792 848.9327346069963 0.6560836628050004 0.5297312939905005 0.7823969890385964 1.024452279839707 1.0741899444430867 0.715927417622034 0.8208516102459477 0.7702657429609573 1.0368065813703697 1.0 9.729506435786915 -5.468434172443312 4.57331133567994 0.9050490444654042 0.5989332874778208 0.5473969369724487 0.11791939277881085 0.16982225889504377 7.406943301228155 0.03331945756794836 0.07002912705464413 3.4006804721922403e-06 5.468434172443312 -0.3061157569875834 GRNS(ph)ATSADEQPHIGNYR ddPTM_A459_Selumetinib_30min_R2 1 GRNSATSADEQPHIGNYR 18 1 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10;F5H4F6;F5H6N2;F5H4J8 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 GRNS(0.94)AT(0.056)S(0.004)ADEQPHIGNYR 112.14 0.00069117 3953200.0 6525.5 5851.3 7526.8 7748.1 8125.3 6865.3 6269.7 6099.1 6603.5 8045.0 True False 6162.838833646219 6300.075895105097 7042.5338825602075 6692.795413781985 7104.52717289637 7810.932758011588 6561.253473174857 6116.8473712396435 7924.384517206076 7812.719946579714 0.7888211628965676 0.8063870122290984 0.9014189591735358 0.8566536954536539 0.9093538769435375 0.9997712463034197 0.8398168010677601 0.782934421438913 1.0142926626565243 1.0 12.93160918517994 -1.5228787452803376 0.1218193325218314 1.0075654940214736 0.370814114243126 0.35219649145510135 0.06849610104701384 127.4277888574261 1.0681614977633682 0.47965883045448 13.792027255584973 0.029999999999999995 1.5228787452803376 -0.6367513797783475 GRPGS(ph)GTSGVDSLSNFIESVK ddPTM_A459_Selumetinib_30min_R1 1 GRPGSGTSGVDSLSNFIESVK 21 1 Q8IXT5;B9ZVT1;E5RHG1;E5RJ83;E5RJV8 Q8IXT5 RBM12B RNA-binding protein 12B 1 GRPGS(0.772)GT(0.173)S(0.053)GVDS(0.001)LSNFIESVK 72.848 0.0023609 10769000.0 2276.0 3683.6 2264.7 2053.5 2850.5 2053.3 2989.6 2881.8 1404.7 2823.7 True False 2329.026371674932 3252.3223995408207 1957.1661791066417 1694.8947739690802 2592.67277829665 2032.6456662472356 2764.0920650592298 2805.365302594351 2383.6733047712155 3186.1494001671717 0.7309846711998916 1.020768956838677 0.6142731972970108 0.531957093374263 0.813732330995093 0.6379630742176077 0.8675337273620009 0.8804876828585496 0.7481360744245541 1.0 11.637598201816221 -7.290117986207243 23.158479230038957 0.8640800976114925 0.72862589146667 0.2224825143182635 0.1359299536773555 538.9232780205419 435186.2448365491 0.05905620785562446 0.039828551745965834 5.1272207218048165e-08 7.290117986207243 -0.1354542061448225 GRPGS(ph)PLAAEETPGR ddPTM_A459_Selumetinib_30min_R1 2 GRPGSPLAAEETPGR 15 1 I3L4Y1 I3L4Y1 ABR 1 GRPGS(0.999)PLAAEET(0.001)PGR;GRPGS(0.992)PLAAEET(0.008)PGR 115.73 0.011109 17254700.0 2808.6000000000004 3531.3 3219.6000000000004 3640.2000000000003 4055.0 2812.6 3264.8 2870.6 1710.42 2541.0 True False 2874.034915415735 3117.8537543431694 2782.3960039968856 3004.507405016919 3688.2259659683955 2784.307797636473 3018.533507494442 2794.4623629770767 2902.457815865868 2867.1621014359835 1.002397078970983 1.0874354654665777 0.9704355406355839 1.0479028735459874 1.2863681352795477 0.9711023301549592 1.0527948545297268 0.9746440082956956 1.0123103309757782 1.0 11.485407757544223 GRPGS(ph)PLAAEETPGR ddPTM_A459_Selumetinib_30min_R2 1 GRPGSPLAAEETPGR 15 1 I3L4Y1 I3L4Y1 ABR 1 GRPGS(1)PLAAEETPGR 68.625 0.031298 15344000.0 7625.4 12310.0 20019.0 19649.0 24310.0 20619.0 12752.0 13929.0 16584.0 14566.0 True False 7201.610794894775 13254.137417111358 18730.999335039167 16972.772303584396 21255.960465842578 23459.08008935383 13344.993267608632 13969.531083929909 19901.263395675855 14145.441732986976 0.5091117641169676 0.9369899977179852 1.3241721035376883 1.1998757355172673 1.5026720880885587 1.6584197603845467 0.9434129749718803 0.9875641459363658 1.4069029282603724 1.0 13.78804960937934 -4.894729764411252 2.314881707623335 1.263418892008161 0.4183169715571944 0.5199701829401748 0.22227918294200044 0.37941348954295306 2.9859994301852546 0.0625120795683398 0.5995466817103143 1.2742957527225211e-05 4.894729764411252 -0.8451019204509667 GRPYDYNGPR ddPTM_A459_Selumetinib_30min_R1 1 GRPYDYNGPR 10 1 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 128.51 0.008749700000000001 3413300.0 1018.2 1304.2 1314.3 1337.5 1592.8 1125.4 1303.8 1009.3 886.99 963.61 False True 1041.9220789276872 1151.503657693869 1135.8252789331293 1103.9307329844871 1448.73152123168 1114.0794977814435 1205.453316304598 982.5300853315554 1505.1572468135698 1087.298729856249 0.9582666201269625 1.0590499428304385 1.0446303741045442 1.0152966270184431 1.3324135138309374 1.0246305520183354 1.1086680074242063 0.903643183195344 1.3843088430835981 1.0 10.0865326526929 -4.893754370730841 0.9821966362108039 1.1098050692215502 0.9162269080452349 0.09700238448342058 0.140402835810064 4.410924624623853 3.846583319455904 0.04597602343558709 0.872222259757417 1.2771609441946743e-05 4.893754370730841 -0.19357816117631532 GRPYDYNGPR ddPTM_A459_Selumetinib_30min_R2 1 GRPYDYNGPR 10 1 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 113.44 0.021484 1627000.0 9985.5 7818.6 10258.0 10395.0 10991.0 8382.0 9831.3 7808.3 7936.5 9985.4 False True 9430.545885123636 8418.26147923858 9598.011448065923 8979.1830676248 9610.212319213311 9536.544415779808 10288.474930351369 7831.020860266353 9524.021764338007 9697.095556815053 0.9725124218762506 0.8681219474342792 0.9897820839066092 0.9259662354584399 0.991040282413152 0.9834433784740411 1.060985206350854 0.8075635446082373 0.982151996805331 1.0 13.243336985236247 -1.8629260711581455 19.418241070165177 0.9547667770832834 0.9340820351609286 0.0 0.06911080455464984 0.0 0.0 0.015333935093492361 0.0 0.013711151477344691 1.8629260711581455 -0.02068474192235481 GRRS(ph)PILLPK ddPTM_A459_Selumetinib_30min_R1 1 GRRSPILLPK 10 2 Q8TD16;Q8TD16-2 Q8TD16 BICD2 Protein bicaudal D homolog 2 1 GRRS(1)PILLPK 125.36 0.0041137 127410000.0 1957.5 3210.8 4550.7 5482.9 4163.2 3219.5 3344.2 2951.5 1761.4 2224.0 True False 2003.1059413680487 2834.8780433395773 3932.739935205809 4525.414441779919 3786.6392950726568 3187.1147530721155 3091.944301569133 2873.216632176844 2988.9671524339865 2509.4720635945005 0.79821806762768 1.1296710907707712 1.5671582849074073 1.803333261776916 1.5089386130279434 1.27003396423827 1.23210947291452 1.1449486423297042 1.1910740891662568 1.0 11.293168170214376 -7.372409824310476 1.9193833546757053 1.1250474998310265 1.3801627270162455 0.14185640663849652 0.2567230522913685 0.7746568362688102 5.5656437679190685 0.1597319233531076 0.09197714536980053 4.2421905842321856e-08 7.372409824310476 0.25511522718521906 GRS(ph)ECDSSPEPK ddPTM_A459_Selumetinib_30min_R2 1 GRSECDSSPEPK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GRS(1)ECDSSPEPK 126.09 0.012342 0.0 8091.4 7746.1 9650.8 8652.3 9379.9 7429.4 7286.8 7014.4 4752.7 8289.9 True False 7641.712380440577 8340.200962362816 9029.878034996556 7473.841813949979 8201.51310463006 8452.732412621628 7625.650638520281 7034.810742703565 5703.372801533325 8050.5490472531055 0.9492163001041494 1.0359791504168951 1.1216474779540164 0.9283642357908617 1.0187520200784894 1.049957259189142 0.9472211887364623 0.8738299340097658 0.7084451964775433 1.0 12.974871463012049 -7.645586861149745 2.768099210482681 0.8391931332052949 1.018245761107589 0.4123582385668846 0.08288998343150021 0.2369690933312451 3.6393688738031935 0.04559201280595503 0.022838662366041946 2.2615861655650387e-08 7.645586861149745 0.17905262790229415 GRS(ph)FAGNLNTYK ddPTM_A459_Selumetinib_30min_R1 3 GRSFAGNLNTYK 12 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 GRS(1)FAGNLNTYK;GRS(1)FAGNLNTYK;GRS(1)FAGNLNTYK 179.5 0.00049313 366731000.0 12084.900000000001 12779.7 13716.6 14136.6 12600.400000000001 11171.599999999999 11526.099999999999 10828.8 6852.0 9259.5 True False 12366.454656878028 11283.44678287866 11853.961059890567 11667.90818684748 11460.696044781309 11059.22384700122 10656.676997283654 10541.585047100325 11627.3435497205 10448.047020167849 1.1836139934101635 1.079957504124765 1.1345623767780606 1.1167549460990112 1.0969223265035797 1.0584967530920963 1.0199683229519436 1.0089526805107136 1.1128724370474459 1.0 13.350945674235016 -6.680520364942347 1.8758471006096196 1.036031711497149 1.1262195030125515 0.5665915822336602 0.03720048642986608 0.25803738397653575 1.8687669455083127 0.014290566768153514 0.013870795861251901 2.086794267636781e-07 6.680520364942347 0.09018779151540257 GRS(ph)IDQDYER ddPTM_A459_Selumetinib_30min_R1 1 GRSIDQDYER 10 1 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;Q9UDY2-5;A0A3B3IRV6;A0A3B3ISF1;A0A3B3ISZ5;A0A3B3IRI3 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 GRS(1)IDQDYER 154.1 0.0027065 18158000.0 3499.2 3630.9 4483.9 4407.4 4329.7 3439.2 3718.6 3337.9 2179.4 2701.5 True False 3580.724551742057 3205.7925400403847 3875.0110082996734 3637.7303271445458 3938.07939947062 3404.6047705437522 3438.1030081379654 3249.368048972752 3698.2826229219 3048.2638398383765 1.1746767143135197 1.0516781710766745 1.2712190321770613 1.1933777777377117 1.2919089706091265 1.116899635145844 1.1278889193267005 1.0659733604769062 1.213242297004707 1.0 11.573772064118302 -6.959515866790781 24.99979887394408 1.1094337970836348 1.193683348112682 0.2552253132776052 0.0782101225637035 239.972567472221 148187.3800323726 0.027465481716770393 0.02422224746833045 1.0977011854279448e-07 6.959515866790781 0.0842495510290473 GRS(ph)PDELPSAGGDGGK ddPTM_A459_Selumetinib_30min_R2 1 GRSPDELPSAGGDGGK 16 1 B4E2I7;A0A2R8Y5N1;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610 B4E2I7 DIAPH1 Protein diaphanous homolog 1 1 GRS(0.998)PDELPS(0.002)AGGDGGK 127.3 0.004981899999999999 3501400.0 9314.1 8580.8 10681.0 11324.0 10889.0 7823.3 9616.3 8079.1 8314.6 9718.0 True False 8796.459609296484 9238.919768379295 9993.796088593506 9781.651665010417 9521.026471104879 8900.888562153445 10063.477004336952 8102.6088434329995 9977.752329334688 9437.416089603694 0.9320834776996544 0.9789670902141251 1.058954696254489 1.036475617069161 1.0088594569432294 0.9431488955921642 1.0663381701928911 0.8585622130573298 1.0572546801582936 1.0 13.204176196686419 GRS(ph)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R1 8 GRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFK 32 1 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-3;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;M0R0K8;M0QYI8;M0QYZ0 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK;GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK;GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK;GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK;GRS(0.82)PQPPAEEDEDDFDDT(0.179)LVAIDTYNCDLHFK;GRS(0.999)PQPPAEEDEDDFDDT(0.001)LVAIDTYNCDLHFK;GRS(0.957)PQPPAEEDEDDFDDT(0.043)LVAIDTYNCDLHFK;GRS(0.999)PQPPAEEDEDDFDDT(0.001)LVAIDTYNCDLHFK 160.23 3.3851000000000006e-24 488870600.0 30377.38 39457.729999999996 32817.22 35418.12 33025.82 30391.71 34174.26 30548.920000000002 19381.3 29805.809999999998 True False 31085.113849908008 34838.00062819899 28360.821776086028 29233.01022245423 30038.64041218208 30085.996990864816 31596.468054345438 29738.663404722956 32888.650545854915 33631.67604667518 0.924280841869642 1.035868702465189 0.8432770860639214 0.8692106269661871 0.8931651330874334 0.8945732276057384 0.9394853830803671 0.8842456547051247 0.9779069737770705 1.0 15.037533057431906 -8.404676348205351 4.710557496245664 0.9989400510614835 0.9111020539525325 0.2921672382580752 0.049275668425293004 0.28579974792817725 9.046238326031803 0.0493241374999297 0.012881057882883216 3.9384347237155005e-09 8.404676348205351 -0.08783799710895102 GRS(ph)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R2 4 GRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFK 32 1 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-3;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;M0R0K8;M0QYI8;M0QYZ0 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK;GRS(0.993)PQPPAEEDEDDFDDT(0.006)LVAIDTYNCDLHFK;GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK;GRS(1)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK 126.86 4.3882e-19 27175400.0 85927.2 84558.4 93978.6 99557.9 106154.9 78935.4 83472.7 87945.2 74491.3 91216.1 True False 81151.71021783535 91043.75738189048 87932.11919216308 85997.94227304292 92818.77242515318 89808.03484578198 87354.34594801707 88201.10597188828 89391.64146082409 88582.45418511012 0.9161149458362624 1.0277854482518285 0.9926584220438504 0.9708236587500007 1.0478234462909601 1.0138354787293515 0.9861359876694465 0.9956949915563984 1.0091348482400704 1.0 16.434733347326308 -4.751975268416064 24.999681835924456 1.0043327759190694 0.9161147716090278 0.6257946996800825 0.020587590816155202 260.01198768218853 686779.253358322 0.005215881636302753 0.06563103092819053 1.7702097628328318e-05 4.751975268416064 -0.08821800431004168 GRS(ph)PSQYHDFAEK ddPTM_A459_Selumetinib_30min_R2 1 GRSPSQYHDFAEK 13 1 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 GRS(0.842)PS(0.15)QY(0.008)HDFAEK 66.708 0.030868 5445200.0 30068.0 28554.0 40157.0 44238.0 47140.0 33033.0 30662.0 29574.0 33014.0 43675.0 True False 28396.940931740777 30743.999984418984 37573.34233963574 38212.70808519344 41217.851763053004 37582.99590628184 32087.84375560035 29660.055443760757 39617.72248823221 42413.98926872207 0.6695182750159727 0.7248551837374786 0.8858714539107021 0.9009458611188257 0.9717985144455358 0.8860990572748879 0.756539158632346 0.6992988859369892 0.9340720637529857 1.0 15.372252562260616 -5.152533083328056 3.7574511319714334 0.8685920097771436 0.6806202152392161 0.4132446782061785 0.0869215055815417 0.25749367701823794 6.414823230621377 0.024264705287793696 0.07614809405381621 7.0382861021693225e-06 5.152533083328056 -0.18797179453792745 GRSECDS(ph)SPEPK ddPTM_A459_Selumetinib_30min_R1 1 GRSECDSSPEPK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GRSECDS(0.609)S(0.391)PEPK 95.428 0.0099243 44667000.0 6735.2 7440.7 11027.0 11114.0 8507.9 8163.2 8017.6 7653.6 4903.2 6683.4 True False 6892.117055582164 6569.539384912417 9529.593966975284 9173.14853561838 7738.3619471917455 8081.085619592567 7412.8259769932065 7450.601665603481 8320.372284440966 7541.279491828908 0.9139187936277761 0.8711438678317934 1.2636574439789356 1.216391534826103 1.02613382192987 1.0715801779192173 0.9829666152839338 0.9879758035325864 1.1033104254332724 1.0 12.880593603900559 -10.088143037359695 15.090555476242491 1.0000676076345534 1.0509142564233207 0.015003307354963913 0.11665855609049264 0.0 0.0 0.12160663169083182 0.029493940425699038 8.163134695910512e-11 10.088143037359695 0.050846648788767324 GRSECDSS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 4 GRSECDSSPEPK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GRSECDS(0.1)S(0.9)PEPK;GRSECDS(0.08)S(0.919)PEPK;GRSECDS(0.081)S(0.919)PEPK;GRSECDS(0.368)S(0.631)PEPK 155.14 0.0020095 47942100.0 11874.0 14732.8 19739.300000000003 20390.5 16415.0 15770.5 14374.400000000001 14067.100000000002 10127.1 11699.3 True False 12150.641097217984 13007.876926907102 17058.811480213604 16829.681952089853 14930.266148303634 15611.863088468333 13290.127435104174 13693.994811619465 17184.949045880687 13201.019115832349 0.9204320507835173 0.9853691455765256 1.2922344351243684 1.2748774775960705 1.130993449619155 1.1826255951515585 1.0067501091006645 1.0373437604673927 1.3017895735996852 1.0 13.688361689178903 -5.0773389607270785 6.794255529399976 1.1537925576813226 0.9356465638535384 0.3625440377871798 0.10779863529674502 0.23577088780063435 17.326523305441732 0.028354300783103827 0.07760769411310979 8.368758573444621e-06 5.0773389607270785 -0.2181459938277842 GRSECDSS(ph)PEPK ddPTM_A459_Selumetinib_30min_R2 2 GRSECDSSPEPK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 GRSECDS(0.038)S(0.962)PEPK;GRSECDS(0.062)S(0.938)PEPK 132.51 0.0049273 45607000.0 106133.0 105296.0 96337.0 108374.0 97838.0 60509.0 79615.0 81237.0 52629.0 101293.0 True False 100234.55274406158 113371.86461999675 90138.78230379484 93613.27424442244 85546.71575718242 68843.56550398705 83317.25525412962 81473.38622049057 63156.27057712398 98368.40789917955 1.018970977417818 1.1525231224255925 0.9163387334293396 0.9516599510319331 0.8696564027432625 0.6998544245480387 0.8469920072257724 0.8282474827080138 0.6420381495027809 1.0 16.58590743205194 -5.8323710522655015 1.1417682876358124 0.7962960987996274 1.0866655073011784 0.5023979639461205 0.10119507661620171 0.40214568753332514 1.038119649645931 0.03612566812620648 0.08957431827095107 1.4710551261524948e-06 5.8323710522655015 0.290369408501551 GRSHSSLPQMS(ph)S(ph)S(ph)RS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GRSHSSLPQMSSSRSK 16 2 C9JLG9;C9JDV3;A0A0J9YXL8;A0A0J9YWU3;Q04671-3;Q04671-2;Q04671 C9JLG9 OCA2 P protein 4 GRS(0.005)HS(0.343)S(0.35)LPQMS(0.684)S(0.627)S(0.996)RS(0.995)K 54.859 0.045026 0.0 18280.0 17861.0 15463.0 17336.0 17379.0 14223.0 13928.0 11339.0 9679.5 19504.0 True False 17264.070780637936 19230.881267833145 14468.127414841436 14974.806893731948 15195.69464976874 16182.089146461009 14575.679597808417 11371.994612727494 11615.670467827093 18940.868842522177 0.9114719564437385 1.0153114636779434 0.7638576421774563 0.7906082354634949 0.8022702008080255 0.8543477746982906 0.7695359552401352 0.6003945598946027 0.6132596431769781 1.0 14.209214890189346 -5.1987336180870924 0.7016685446414916 0.7409186581914081 1.0397425414698134 0.23040004623097554 0.11681685014202708 2.54909189419331 1.385645620385002 0.055129324940135026 0.5537625571961482 6.327998709370246e-06 5.1987336180870924 0.29882388327840526 GRTSS(ph)TNEDEDLNPEQK ddPTM_A459_Selumetinib_30min_R1 3 GRTSSTNEDEDLNPEQK 17 1 Q99081;Q99081-3;B4DGI9;Q99081-4;Q99081-2;B4DZP2;F5GY10 Q99081 TCF12 Transcription factor 12 1 GRT(0.04)S(0.118)S(0.631)T(0.211)NEDEDLNPEQK;GRT(0.001)S(0.011)S(0.761)T(0.226)NEDEDLNPEQK;GRT(0.001)S(0.001)S(0.941)T(0.057)NEDEDLNPEQK 172.6 2.5073e-06 43822000.0 9112.699999999999 8755.6 13503.3 15262.300000000001 12497.999999999998 10676.5 11326.7 10977.4 5804.2 7002.3 True False 9325.008179772478 7730.490281631986 11669.626028317529 12597.025813853563 11367.558106701114 10569.104103486385 10472.317899821515 10686.243692379498 9849.303478004622 7901.113413177955 1.1802144447413785 0.9784051787863982 1.4769596913840295 1.5943355265402823 1.4387286338330003 1.3376727494961145 1.3254230577623591 1.3524984560475153 1.246571585920708 1.0 12.947840254722102 -8.69918048433049 2.30890498121106 1.0000874067589232 1.340317256435322 0.28976349606589824 0.15815153617124683 1.0045991728556694 9.825814441591314 0.16958090359079395 0.04619364392694781 1.99903093865055e-09 8.69918048433049 0.3402298496763989 GRVQLFEISLS(ph)HGR ddPTM_A459_Selumetinib_30min_R1 1 GRVQLFEISLSHGR 14 1 Q5T370;Q8N5I2;F2Z3I4;Q5T371 Q5T370 ARRDC1 Arrestin domain-containing protein 1 1 GRVQLFEIS(0.255)LS(0.745)HGR 78.249 0.021167 17414000.0 1761.8 2062.0 3037.8 3498.6 3055.4 2430.7 2313.0 1887.8 1436.6 1356.0 True False 1802.846512133961 1820.5800814022082 2625.2834454409654 2887.6351868557185 2779.039609474682 2406.2493648990167 2138.5285477930174 1837.7294115613895 2437.8052748874 1530.055808558518 1.1782880742320385 1.1898782196169668 1.7158089468084652 1.8872744188175663 1.8162995061551677 1.5726546387650853 1.3976800949553259 1.201086523303182 1.5932786642495627 1.0 10.579368560627213 -9.014895243807892 0.6432089303173512 0.9977326371488277 1.5518462846267371 0.268064677307863 0.24796041310972414 2.5436251222777804 1.8140460639589513 0.34216220975214 0.11201124719031573 9.662839282728916e-10 9.014895243807892 0.5541136474779095 GRWES(ph)QQDVSQTTVSR ddPTM_A459_Selumetinib_30min_R1 3 GRWESQQDVSQTTVSR 16 1 Q9NQT8;H0YBA8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 GRWES(0.98)QQDVS(0.02)QTTVSR;GRWES(1)QQDVSQTTVSR;GRWES(0.998)QQDVS(0.001)QT(0.001)TVSR 204.9 8.9374e-07 27684100.0 4487.1 5161.3 4854.7 6170.0 5843.8 4712.9 5267.3 5078.799999999999 2487.73 3937.6000000000004 True False 4591.640699623284 4557.012596576725 4195.458404958281 5092.525325244328 5315.22932180669 4665.4925049708245 4869.983320272439 4944.093725732593 4221.496113389691 4443.02931547199 1.0334482114789976 1.0256544067147633 0.9442788032814478 1.1461831475004214 1.1963075065243058 1.0500701601774602 1.0960952481933137 1.1127754004493609 0.9501391536376201 1.0 12.117327945061666 -5.761864922442288 24.999999989078187 1.08791500376082 1.0035798740765693 0.19804061905801307 0.06990606054922589 16.993673155119282 998476.9755717141 0.01965429259795839 0.031297205618152316 1.7303544634735059e-06 5.761864922442288 -0.08433512968425072 GRWES(ph)QQDVSQTTVSR ddPTM_A459_Selumetinib_30min_R2 2 GRWESQQDVSQTTVSR 16 1 Q9NQT8;H0YBA8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 GRWES(0.993)QQDVS(0.002)QT(0.001)T(0.002)VS(0.002)R;GRWES(1)QQDVSQTTVSR 74.047 0.018198 24388800.0 38087.3 27073.0 34080.1 42093.0 50175.0 37021.1 30672.9 35034.0 32527.8 38988.0 True False 35970.560341542194 29149.412046584563 31887.42346960731 36359.860785524856 43871.56792980877 42120.42048091456 32099.25062719831 35135.94313980907 39034.268902669115 37862.3151370106 0.9500359450122688 0.7698792834274117 0.8421942333483247 0.9603179481748836 1.1587132950283883 1.11246288898329 0.8477889033209471 0.9279924646093157 1.0309530402833957 1.0 15.208475008619773 -5.858547274774383 4.429825594259731 1.0100143650377214 0.8456977148096605 0.3742149517874267 0.09126633446840542 0.23918250688744824 8.285243270023418 0.028451196570969874 0.04388818707861578 1.3850094136395827e-06 5.858547274774383 -0.16431665022806086 GRYS(ph)VGSEVIDLVLER ddPTM_A459_Selumetinib_30min_R1 2 GRYSVGSEVIDLVLER 16 1 A6NHL2-2;A6NHL2 A6NHL2-2 TUBAL3 Tubulin alpha chain-like 3 1 GRY(0.383)S(0.614)VGS(0.003)EVIDLVLER;GRY(0.396)S(0.604)VGSEVIDLVLER 109.39 0.01414 16727200.0 1109.15 1159.2 1533.06 1668.23 1717.5 1266.5 986.3 1380.23 661.8399999999999 988.06 True False 1134.9910369697936 1023.48032510254 1324.8788724957956 1376.9049470554853 1562.152428249254 1253.7601598899932 911.9025969253141 1343.6218167811096 1123.0941411189447 1114.8871255194167 1.0180322393094374 0.9180125069842464 1.1883524727927461 1.2350173533612172 1.4011754127319929 1.124562416402357 0.81793266426004 1.205163990170868 1.0073612973113348 1.0 10.122681939474502 -7.020751925995858 24.786965025580365 1.0170737750935026 1.15744450624274 0.17733362431057642 0.1478384331895975 1412.8119853215665 1687517.7303559864 0.06084969051777339 0.04770150342800342 9.53340567623407e-08 7.020751925995858 0.14037073114923748 GS(ph)EDSPPKHAGNNESHSSR ddPTM_A459_Selumetinib_30min_R2 2 GSEDSPPKHAGNNESHSSR 19 1 P48651-2;P48651 P48651-2 PTDSS1 Phosphatidylserine synthase 1 1 GS(0.98)EDS(0.02)PPKHAGNNESHSSR;GS(0.906)EDS(0.094)PPKHAGNNESHSSR 62.589 0.013443 3005700.0 10982.9 4609.700000000001 15508.8 22374.0 12495.9 8130.2 13793.0 10166.1 13373.900000000001 19637.0 True False 10372.514386032184 4963.249167478333 14510.980692704707 19326.62260269718 10926.053327236617 9250.061251392624 14434.401830310991 10195.681667911549 16049.05369798778 19070.028786946663 0.5439170806670264 0.2602643773078965 0.760931242150898 1.0134553449613122 0.5729437249048855 0.48505754001400586 0.756915576351477 0.5346442725293861 0.8415851846523312 1.0 14.219019401005774 -14.522878745280334 0.08255843673507675 2.1290411566136695 0.30961227670175956 0.2885256784909326 0.19185718586409586 365.72414612541235 2.120049911704473 75.27072136955829 6.490098889545928 3.000000000000026e-15 14.522878745280334 -1.81942887991191 GS(ph)EGDCSPEDKNSVTAK ddPTM_A459_Selumetinib_30min_R1 1 GSEGDCSPEDKNSVTAK 17 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GS(0.603)EGDCS(0.353)PEDKNS(0.034)VT(0.01)AK 78.902 0.010051 19438000.0 7242.7 8642.8 10212.0 10806.0 7589.2 7545.6 7380.1 6839.4 4511.7 6669.2 True False 7411.440818159063 7630.896958071288 8825.26649050074 8918.934953742335 6902.758199982088 7469.698114856638 6823.4131152474065 6657.99689449781 7656.025378469637 7525.256783509196 0.9848754708810006 1.0140380823673143 1.1727528700203798 1.1852000815822308 0.9172787585280481 0.9926170401554524 0.9067349210195982 0.8847534490900172 1.017377293389776 1.0 12.877525096298498 -6.278816440783962 24.840355513048543 0.9470194833812284 1.0898136097358142 0.47462639255510897 0.06996582271839975 682.508170441405 975636.9460866257 0.023175969025035163 0.02633958231529886 5.262396402154036e-07 6.278816440783962 0.14279412635458577 GS(ph)ESPNSFLDQESR ddPTM_A459_Selumetinib_30min_R1 1 GSESPNSFLDQESR 14 0 A0A5H1ZRR2;Q6P9H4;Q5T4Y8;G9CGD6-3;G9CGD6;G9CGD6-2 A0A5H1ZRR2 CNKSR3 Connector enhancer of kinase suppressor of ras 3 1 GS(0.691)ES(0.244)PNS(0.065)FLDQESR 140.77 0.00055974 20441000.0 1507.2 1788.6 1769.5 1802.8 1679.0 1555.5 1408.2 1376.3 830.74 1107.0 True False 1542.314827499322 1579.1898805024196 1529.2116191677503 1487.9748227472394 1527.1347464515256 1539.853082280998 1301.9783402516753 1339.7960531475483 1409.7051051510216 1249.0942330931264 1.2347465760690408 1.264268010101911 1.2242564080861782 1.1912430490232704 1.222593705096123 1.2327757518084659 1.0423379643884771 1.0726140731831075 1.1285818698083132 1.0 10.28666660427242 -7.25716535415662 24.932595951666283 1.066934646172969 1.227818717997486 0.8516163869730681 0.034200542174844493 132.70608233283232 774146.1703636852 0.013467460933313902 0.010058952859218324 5.531394656825122e-08 7.25716535415662 0.16088407182451703 GS(ph)ESPNSFLDQESR ddPTM_A459_Selumetinib_30min_R2 1 GSESPNSFLDQESR 14 0 A0A5H1ZRR2;Q6P9H4;Q5T4Y8;G9CGD6-3;G9CGD6;G9CGD6-2 A0A5H1ZRR2 CNKSR3 Connector enhancer of kinase suppressor of ras 3 1 GS(0.939)ES(0.061)PNSFLDQESR 197.73 0.00010174 13152000.0 15129.0 13391.0 14299.0 16429.0 16386.0 15109.0 15089.0 15594.0 12537.0 17162.0 True False 14288.19074618552 14418.046641148525 13379.017907574056 14191.34185839422 14327.444187301367 17190.127604153793 15790.66839828628 15639.37595827432 15044.750313048013 16666.488467768948 0.8573006109725646 0.865092047975874 0.8027496574006889 0.851489615574308 0.8596558426214964 1.0314186841095834 0.947450233972417 0.938372590514136 0.9026946703345946 1.0 14.02466254843323 -6.632590612506863 7.619185471546429 0.9588421233152461 0.8443464174517338 0.7229162118770704 0.036151110522701445 0.13184646204822748 8.402679066710386 0.01220568866201269 0.012191542378126701 2.3302868664979343e-07 6.632590612506863 -0.11449570586351232 GS(ph)ETPGATPGSK ddPTM_A459_Selumetinib_30min_R2 1 GSETPGATPGSK 12 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GS(0.968)ET(0.032)PGATPGSK 166.45 0.00046998 220650000.0 153820.0 131050.0 147170.0 167780.0 166010.0 124030.0 131550.0 144340.0 121530.0 119340.0 True False 145271.30019024774 141101.1136078348 137701.24242658025 144928.0745633561 145154.33965177 141114.00666776072 137667.33566137977 144760.00550322665 145839.39583191517 115894.34411744242 1.2534804980908814 1.2174978397983676 1.1881618855104754 1.2505189590312717 1.2524712983808488 1.2176090881946902 1.1878693193334224 1.2490687669497744 1.2583823390391484 1.0 16.822450636011396 -10.62144117525326 4.095449314519504 0.9999593732823189 1.2290699158891785 0.88036228553965 0.02549304721793977 4737202.9252545005 7419626.98782222 2322.685954598294 0.006645974326750051 2.3908857564623435e-11 10.62144117525326 0.2291105426068596 GS(ph)FMLGLETHDR ddPTM_A459_Selumetinib_30min_R1 1 GSFMLGLETHDR 12 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 1 GS(1)FMLGLETHDR 71.354 0.040019 2220200.0 2714.3 3256.9 3057.5 3540.5 2926.6 2696.5 2709.1 2786.6 1649.1 2783.1 True False 2777.537908891594 2875.580633908269 2642.3082936453197 2922.218138416131 2661.8895467331954 2669.3756582261085 2504.7504058910768 2712.690315847532 2798.4022545014673 3140.3379946896844 0.8844710071299376 0.9156914442874875 0.8414088859586027 0.9305425541319455 0.8476442826327784 0.850028137971144 0.7976053565337913 0.8638211302205988 0.8911149880151656 1.0 11.61670412945423 -8.72709888911843 3.0357745719741978 0.9999729816038941 0.8661773776125491 0.5534400179157979 0.035866630767175375 0.9314051613438777 12.73734235607797 0.03633979808673019 0.00965524345310438 1.8745676192775295e-09 8.72709888911843 -0.13379560399134505 GS(ph)FSQADVHR ddPTM_A459_Selumetinib_30min_R2 2 GSFSQADVHR 10 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206 Q2TAM5 RELA Transcription factor p65 1 GS(0.983)FS(0.017)QADVHR;GS(0.973)FS(0.027)QADVHR 117.03 0.0040061 2185600.0 37459.0 34411.0 44702.0 43686.0 44530.0 33031.0 33096.0 35148.0 31484.0 42359.0 True False 35377.17874025802 37050.213051195686 41825.92198785757 37735.89143744656 38935.74329674907 37580.720424436025 34635.02957847987 35250.27486093535 37781.679736460384 41135.98560810073 0.8600056183725265 0.9006764394603335 1.0167720882229443 0.9173450174976577 0.9465129550483317 0.913572869809528 0.8419642574860136 0.856920633840208 0.9184581134484888 1.0 15.328113390090236 -7.005224016594762 24.24623531074327 0.890320484834163 0.9309407929368545 0.015268124137573724 0.05478802390800836 373.3590509236208 1732879.964503283 0.01965299796698342 0.016826651593686768 9.88043313385035e-08 7.005224016594762 0.04062030810269146 GS(ph)FWALHPSCGDMFENGSFLRRR ddPTM_A459_Selumetinib_30min_R2 1 GSFWALHPSCGDMFENGSFLRRR 23 2 Q99853 Q99853 FOXB1 Forkhead box protein B1 1 GS(0.757)FWALHPS(0.039)CGDMFENGS(0.205)FLRRR 41.423 0.041603 5378900.0 28422.0 24863.0 30989.0 28645.0 26752.0 22138.0 24712.0 18660.0 19659.0 31232.0 True False 26842.419022280716 26769.912152854584 28995.201478272098 24743.501584618793 23391.17459408559 25187.308551244718 25861.15696589902 18714.297510670705 23591.349318354547 30330.251009518688 0.8850048426521967 0.8826142633786068 0.955982905290576 0.8158027303121699 0.7712159911483959 0.8304352160930044 0.852652256579838 0.6170175612723253 0.7778158285254797 1.0 14.88846981713202 -5.898701982020643 6.138955033133368 0.7925098843364666 0.9046509684027538 0.185182115853034 0.09118185217847949 0.30656068075806525 15.926521437849626 0.02546687837152859 0.03815427850661629 1.2626937126366379e-06 5.898701982020643 0.1121410840662872 GS(ph)GFSLDVIDGPISQR ddPTM_A459_Selumetinib_30min_R1 1 GSGFSLDVIDGPISQR 16 0 O43166-3;O43166-2;O43166 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 GS(1)GFSLDVIDGPISQR 206.13 5.3807e-29 0.0 611.09 827.51 413.28 433.37 507.05 570.0 860.05 635.4 360.11 672.77 True False 625.3272080258499 730.624744501038 357.1588459845424 357.6900648624204 461.18741702694825 564.2663175185917 795.1757360697728 618.5471279299227 611.0803686062239 759.1265828347449 0.8237456336869948 0.9624544325305079 0.4704865487002616 0.47118632511422187 0.6075237351124939 0.743309917315104 1.0474876707655427 0.8148142113797836 0.804978224216989 1.0 9.568196661978453 -7.039150869309315 7.37511670925982 0.9012897610258767 0.6628038220448745 0.3657663603917536 0.15503113896230078 0.3203214637830464 51.39729423676444 0.06499116149462798 0.05115028230999349 9.137957433500238e-08 7.039150869309315 -0.23848593898100212 GS(ph)GGGGGGGGQGSTNYGK ddPTM_A459_Selumetinib_30min_R1 1 GSGGGGGGGGQGSTNYGK 18 0 Q99729-3;Q99729-4 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 GS(0.999)GGGGGGGGQGS(0.001)TNYGK 260.11 1.3419e-42 22648000.0 2022.9 2747.9 2059.9 2193.8 2357.6 2244.4 2346.8 2094.2 1247.3 2024.3 True False 2070.029634121801 2426.1745905359467 1780.1768942207668 1810.6940127262562 2144.355496268086 2221.8233737521527 2169.778986580481 2038.6550130797032 2116.5770008123714 2284.1386233517746 0.9062626991895144 1.0621836020511517 0.7793646480214551 0.7927250974239122 0.9388026953992096 0.9727182715783774 0.9499331452118783 0.8925268336333083 0.9266412200965626 1.0 11.157434494536812 -6.48047403521201 24.989036048074507 0.9433022817980301 0.8871677576363614 0.1339337964157431 0.07649557259612993 1221.3783367250578 719756.4241083881 0.02548873971527152 0.028899344552330588 3.307698869208232e-07 6.48047403521201 -0.05613452416166875 GS(ph)GGGGGGGGQGSTNYGK ddPTM_A459_Selumetinib_30min_R2 2 GSGGGGGGGGQGSTNYGK 18 0 Q99729-3;Q99729-4 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 GS(1)GGGGGGGGQGSTNYGK;GS(1)GGGGGGGGQGSTNYGK 195.56 2.8535e-10 11189300.0 32457.0 25998.0 34418.0 38987.0 32404.0 32082.0 36859.0 47618.0 34288.0 43229.0 True False 30653.169875665513 27991.96300325437 32203.583351484984 33676.903343673715 28333.1198245645 36501.004288600285 38573.01653472291 47756.56049641571 41146.558086766396 41980.86644756926 0.7301700148077903 0.6667790679883677 0.7671014458861797 0.8021964812406498 0.6749055515552614 0.8694676260240393 0.918823735639128 1.1375792006594203 0.980126461614487 1.0 15.357444322423243 -7.208765661757494 1.8364372303045884 1.0406137334142045 0.7312796946620962 0.8244684828121775 0.061399808649445164 0.13360542612925813 0.8819251258918451 0.030468302411694438 0.01985149247703433 6.183499617255143e-08 7.208765661757494 -0.3093340387521083 GS(ph)GGLFSPSTAHVPDGALGQR ddPTM_A459_Selumetinib_30min_R1 4 GSGGLFSPSTAHVPDGALGQR 21 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 GS(0.986)GGLFS(0.013)PSTAHVPDGALGQR;GS(0.792)GGLFS(0.197)PS(0.006)T(0.006)AHVPDGALGQR;GS(1)GGLFSPSTAHVPDGALGQR;GS(1)GGLFSPSTAHVPDGALGQR 384.53 5.245099999999994e-268 84276100.0 6429.280000000001 7411.83 6093.5 7089.52 7733.25 6606.18 7957.39 6660.290000000001 2908.8100000000004 5048.71 True False 6579.069714798859 6544.049497933712 5266.03616919959 5851.468418772468 7033.778902916181 6539.727827131521 7357.157665768555 6483.637473529088 4936.038118923304 5696.761107099908 1.1548789902036307 1.1487315993956324 0.9243912585059074 1.0271570649995745 1.2346978872169907 1.1479729804679746 1.2914632591138997 1.1381269727895893 0.8664639478688143 1.0 12.47592619291935 -8.250089830664036 24.27911629424082 0.9332319790565297 1.1325558139037533 0.39051842295233063 0.10003529956082213 484.33945662823817 1036113.5780478696 0.07515929828697117 0.027815645078569252 5.622250209941414e-09 8.250089830664036 0.1993238348472236 GS(ph)GGLFSPSTAHVPDGALGQR ddPTM_A459_Selumetinib_30min_R2 4 GSGGLFSPSTAHVPDGALGQR 21 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 GS(0.998)GGLFS(0.002)PSTAHVPDGALGQR;GS(1)GGLFSPSTAHVPDGALGQR;GS(1)GGLFSPSTAHVPDGALGQR;GS(1)GGLFSPSTAHVPDGALGQR 295.53 2.271599999999998e-87 83652000.0 68272.5 64174.6 98140.0 125733.0 138565.0 107290.0 94891.0 101269.0 101242.0 113125.0 True False 64478.18776647171 69096.58546613771 91825.77924675286 108607.94849847692 121157.22591318286 122068.22361835075 99303.61952294939 101563.67602401454 121493.22893783248 109858.78731595172 0.5869188013247744 0.6289582031104829 0.8358528388144657 0.9886141213822304 1.1028451057332087 1.1111375484901806 0.9039205870473895 0.9244929650635902 1.105903605038169 1.0 16.74529074620179 -5.450625073269013 1.9879560523371678 1.0212613559181307 0.586366436749146 0.8551423269332682 0.06793809422940404 0.13268914747219737 1.0022044493603601 0.021597780149257947 0.06251280198204216 3.5430307918937695e-06 5.450625073269013 -0.4348949191689847 GS(ph)GIFDESTPVQTR ddPTM_A459_Selumetinib_30min_R2 1 GSGIFDESTPVQTR 14 0 A6NGP5;Q9H910;Q9H910-3;H3BMV3;H3BTV5;Q9H910-2;H3BU16;H3BMT0 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 GS(1)GIFDESTPVQTR 153.2 0.00036787 2286900.0 8291.6 7260.7 7494.4 9921.4 7171.9 7639.2 9289.4 10023.0 9519.1 7825.9 True False 7830.7860659046755 7817.5723431698225 7012.218463285753 8570.088204630376 6270.901804400503 8691.430458246847 9721.375506596898 10052.165270603022 11423.185985876631 7599.945932869882 1.0303739177980735 1.0286352577008084 0.922666888057427 1.1276512070388045 0.8251245284889143 1.1436174066260494 1.2791374560379174 1.3226627346291049 1.5030614805391151 1.0 12.891773439710684 -7.076181931393795 3.4581067999479225 1.302106054047022 0.9922960826023953 0.48922265437515855 0.1375456552375964 0.19201023323694918 4.419757438761033 0.05239470302321465 0.040670649193543115 8.391083998721158e-08 7.076181931393795 -0.30980997144462663 GS(ph)GLAGPK ddPTM_A459_Selumetinib_30min_R2 1 GSGLAGPK 8 0 Q9Y6W5 Q9Y6W5 WASF2 Wiskott-Aldrich syndrome protein family member 2 1 GS(1)GLAGPK 82.749 0.040563 12344000.0 39736.0 42419.0 35130.0 37150.0 42893.0 39061.0 53140.0 63949.0 41729.0 69766.0 True False 37527.632195811195 45672.40090141726 32869.77404665198 32090.10591267545 37504.397871714726 44441.298189546054 55611.11529491235 64135.08100267318 50075.96600567762 67751.67430616284 0.5538997018173705 0.6741147192175412 0.48515072702287565 0.4736429946758743 0.5535567682392056 0.6559439105330506 0.8208079854028617 0.946619868209505 0.739110383890876 1.0 16.047968978906752 -7.177327352554027 2.137261182513466 0.8846139073256662 0.5475404464335656 0.7901691038234999 0.08049599445274919 0.14870519505579904 1.3302179290050113 0.038264734015758355 0.026355950735768047 6.647718907693847e-08 7.177327352554027 -0.33707346089210066 GS(ph)IGLLLGK ddPTM_A459_Selumetinib_30min_R1 2 GSIGLLLGK 9 0 Q8IY63-2;Q8IY63 Q8IY63-2 AMOTL1 Angiomotin-like protein 1 1 GS(1)IGLLLGK;GS(1)IGLLLGK 112.13 0.009872399999999998 10115900.0 4319.3 7760.799999999999 5199.4 5403.2 5497.3 5348.0 7271.2 5589.2 2750.8 5266.8 True False 4419.931286105243 6852.161928101964 4493.350038259843 4459.632550625633 5000.0701856271435 5294.2039755954875 6722.727529923294 5440.956259719741 4667.906689517094 5942.845082976406 0.7437399468423583 1.1530103565597467 0.7560940888617949 0.7504204616405845 0.8413596713045927 0.890853438323845 1.1312304857451025 0.9155473823986507 0.785466661900469 1.0 12.536938058184306 -7.01245804293817 23.95729455660614 0.9595974843161209 0.8562805524028858 0.12385365741029586 0.13621031121471477 832.2264989436211 1600402.971650634 0.05149118333277458 0.04204434692792645 9.717218248014493e-08 7.01245804293817 -0.1033169319132351 GS(ph)IGLLLGK ddPTM_A459_Selumetinib_30min_R2 2 GSIGLLLGK 9 0 Q8IY63-2;Q8IY63 Q8IY63-2 AMOTL1 Angiomotin-like protein 1 1 GS(1)IGLLLGK;GS(1)IGLLLGK 121.9 0.0061157 5597200.0 45031.0 32732.0 42991.0 37331.0 39121.0 35777.0 30307.0 34756.0 28232.0 37132.0 True False 42528.357293375644 35242.43915003163 40225.00586506162 32246.453400433053 34206.270233822586 40704.95699872992 31716.335552181226 34857.13420583445 33879.18886798845 36059.90267947772 1.179380811739662 0.9773304011185998 1.115505114437104 0.8942468227676343 0.9485957446382665 1.1288149433053178 0.8795457889638597 0.9666452656754456 0.9395252441230146 1.0 15.138107882697287 -1.5228792364430992 0.8212976603823935 0.9715581354412386 56.31746172021391 0.35185086489328543 0.07873457820215611 648.501139701764 2.0529996626111733 0.026820823724886655 66908.04376494487 0.029999966071697592 1.5228792364430992 55.34590358477267 GS(ph)ISSGLEFVSHNPPSEAATPPVAR ddPTM_A459_Selumetinib_30min_R1 1 GSISSGLEFVSHNPPSEAATPPVAR 25 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06;F8VRK6 Q99700;F8WB06 ATXN2 Ataxin-2 1 GS(0.652)IS(0.316)S(0.031)GLEFVSHNPPSEAATPPVAR 86.88600000000002 5.5173e-05 6817600.0 677.72 990.5 798.79 652.76 993.35 972.5 984.26 912.23 432.01 539.18 True False 693.5095573864388 874.5317995290425 690.318705439393 538.7677198227693 903.5016678901864 962.7175329593513 910.0164757677276 888.0346970593534 733.0894172379966 608.3890050579514 1.1399113915945593 1.43745497084672 1.1346666354919375 0.8855645242494966 1.485072314553292 1.5824045552362485 1.495780607805437 1.4596494835976936 1.2049682212257715 1.0 9.248850270365567 -6.306993704511289 24.997528481889063 1.4110730435156364 1.1689218540514998 0.2071407390417097 0.20254437802148723 624.2667404624655 342559.1695645432 0.0633462048175537 0.07182809709173417 4.931809530041368e-07 6.306993704511289 -0.2421511894641366 GS(ph)ISSGLEFVSHNPPSEAATPPVAR ddPTM_A459_Selumetinib_30min_R2 1 GSISSGLEFVSHNPPSEAATPPVAR 25 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06;F8VRK6 Q99700;F8WB06 ATXN2 Ataxin-2 1 GS(0.764)IS(0.216)S(0.02)GLEFVSHNPPSEAATPPVAR 57.06800000000001 0.0072753 3426600.0 5775.2 5132.8 8272.6 11173.0 9335.4 7540.9 7179.4 7825.9 10944.0 9613.8 True False 5454.237503957344 5526.4692554467265 7740.349922525856 9651.218125499947 8162.603592465109 8579.590525525402 7513.25632571121 7848.672073352508 13133.105800909098 9336.224614347808 0.5842016156697143 0.5919383352188966 0.8290663777123111 1.0337388531407075 0.8742938317830217 0.9189571673693863 0.8047424559778606 0.8406687282663224 1.4066827163440652 1.0 13.188623555016218 -4.348568446178471 0.4800184402542953 1.0111588803926337 1.2928329509449746e-28 0.4760712360317114 0.1612939639282329 6.744552208469735 0.8799937876093148 0.10619073089481802 4.2050756516116925 4.4815841325275354e-05 4.348568446178471 -1.0111588803926337 GS(ph)LASLDSLR ddPTM_A459_Selumetinib_30min_R1 3 GSLASLDSLR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;E9PKY0 O60716-5 CTNND1 Catenin delta-1 1 GS(0.789)LAS(0.211)LDSLR;GS(0.999)LAS(0.001)LDSLR;GS(0.999)LAS(0.001)LDSLR 152.64 0.00062605 261418000.0 3712.58 5789.6 5306.4 5928.9 4793.4 4255.860000000001 4803.599999999999 4446.91 3386.2299999999996 4615.9 True False 3799.075890576855 5111.750940487979 4585.820025968771 4893.528914236806 4359.837816343505 4213.049912411706 4441.26058459945 4328.963501200586 5746.184989546121 5208.395727673495 0.7294138328221539 0.981444423150872 0.8804668972449953 0.9395462960381977 0.8370788327735178 0.8088958928421529 0.85271181699999 0.8311510352793917 1.1032543013226164 1.0 12.34662335157248 -8.25773974593451 24.9978148816831 1.0516271599750868 0.8627423716536415 0.5553300273177967 0.0693304386562279 218.66040508705996 1477479.272020222 0.04995317636875629 0.01719487275465205 5.524083747712587e-09 8.25773974593451 -0.18888478832144528 GS(ph)LASLDSLR ddPTM_A459_Selumetinib_30min_R2 3 GSLASLDSLR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;E9PKY0 O60716-5 CTNND1 Catenin delta-1 1 GS(0.998)LAS(0.002)LDSLR;GS(1)LASLDSLR;GS(0.998)LAS(0.001)LDSLR 177.57 8.378799999999999e-05 7012100.0 38335.0 40688.0 40329.0 36308.1 45305.0 33085.0 37421.0 39336.0 33221.6 41724.0 True False 36204.49416716386 43808.638767459575 37734.276046895204 31362.874145033966 39613.38086816115 37642.15843427283 39161.1506483048 39450.461247574625 39866.848289060865 40519.31970802886 0.8935118957584566 1.0811790297352633 0.9312662778841817 0.7740227222723941 0.9776418052821306 0.9289928534218228 0.9664809510744342 0.9736210166370972 0.983897276073006 1.0 15.306322332017917 -7.56347536491536 1.4551336099861543 0.9897836328970006 0.9319075920680635 0.1108404975329963 0.07143480267515111 1.1622617546775649 4.698770545933465 0.054233259449160756 0.02473093405777892 2.7322764261654026e-08 7.56347536491536 -0.05787604082893705 GS(ph)LASLDSLRK ddPTM_A459_Selumetinib_30min_R2 1 GSLASLDSLRK 11 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;E9PKY0 O60716-5 CTNND1 Catenin delta-1 1 GS(0.913)LAS(0.087)LDSLRK 140.63 0.0019224 20459000.0 58740.0 49472.0 64385.0 59040.0 64390.0 47490.0 54950.0 61101.0 53815.0 59029.0 True False 55475.465954850755 53266.3433224479 60242.539197087615 50998.6501503192 56300.752546096395 54031.316428702354 57505.283881359304 61278.793794184916 64579.50371673273 57324.6793942392 0.9677414080823575 0.9292043825682671 1.0509005865132084 0.8896456236516564 0.9821381147009833 0.9425489509869319 1.0031505538108296 1.068977523149359 1.1265567361066235 1.0 15.80686876066586 -7.622603524059854 3.1105530778340995 1.0743221509760599 0.961174803824565 0.4816362501975714 0.04833628768925133 0.19834522711718228 3.8220801680097223 0.024803777310048302 0.01299164648440932 2.3844953285118464e-08 7.622603524059854 -0.11314734715149488 GS(ph)LDESSLGFGYPK ddPTM_A459_Selumetinib_30min_R1 4 GSLDESSLGFGYPK 14 0 Q2KJU6;Q9BUZ4 Q2KJU6 TRAF4 TNF receptor-associated factor 4 1 GS(0.999)LDES(0.001)S(0.001)LGFGYPK;GS(0.893)LDES(0.039)S(0.069)LGFGYPK;GS(0.987)LDES(0.012)SLGFGYPK;GS(0.993)LDES(0.002)S(0.004)LGFGYPK 253.06 9.7811e-28 114606000.0 19094.199999999997 21126.2 19305.5 20102.5 19677.800000000003 18974.199999999997 20260.5 18221.600000000002 11398.82 15587.3 True False 19539.057709154426 18652.734682696067 16683.919137520763 16591.9757456603 17897.946464397774 18783.336775195177 18732.234173177872 17738.303975901606 19342.96500312682 17588.08178815944 1.1109260205003373 1.0605326326861504 0.9485923103196294 0.9433647139866194 1.0176178778317337 1.067958234526769 1.065052710056687 1.0085411353865374 1.0997768395726244 1.0 14.10231052605377 -6.638323484845114 6.8695867644669475 1.0496675476679365 1.010205125625528 0.07923172226309216 0.05309471427261296 0.5594904347644739 31.52051042408054 0.01888579145746206 0.0188523379878953 2.2997282235554307e-07 6.638323484845114 -0.03946242204240846 GS(ph)LDESSLGFGYPK ddPTM_A459_Selumetinib_30min_R2 2 GSLDESSLGFGYPK 14 0 Q2KJU6;Q9BUZ4 Q2KJU6 TRAF4 TNF receptor-associated factor 4 1 GS(1)LDESSLGFGYPK;GS(1)LDESSLGFGYPK 220.85 7.1525000000000015e-09 21335300.0 115312.0 108057.0 122452.0 142032.0 140839.0 122803.0 118397.0 136490.0 108675.0 132106.0 True False 108903.42067050996 116344.62444198226 114573.57163565712 122686.99658113395 123145.54570336499 139717.99855535763 123902.69509920475 136887.16330286427 130413.03663320503 128291.75652739106 0.8488730969028273 0.9068752941826156 0.8930704102659548 0.9563123921757166 0.9598866601929539 1.0890645068494873 0.9657884376440881 1.0669989016296464 1.016534812237613 1.0 16.96906894650794 -6.0510556117528935 1.1948811716463363 1.028009673932175 0.8736285206341609 0.7288793901408339 0.03737812220505117 0.2356025368300653 0.6858527104435542 0.01365405003547002 0.025002002136026238 8.89087262239292e-07 6.0510556117528935 -0.15438115329801405 GS(ph)LDWPSEER ddPTM_A459_Selumetinib_30min_R2 1 GSLDWPSEER 10 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 GS(1)LDWPSEER 90.614 0.02919 1192700.0 8393.4 9038.8 9488.6 11052.0 11564.0 9670.6 10949.0 7931.0 8184.2 9590.9 True False 7926.928429442364 9732.046895677187 8878.113806406549 9546.698534236592 10111.226936528325 11002.637369033664 11458.150195031909 7954.0778969522735 9821.268685654262 9313.985796849147 0.851078002730473 1.044885305598111 0.9532024205372902 1.0249853008650893 1.0855961300637669 1.181302785833727 1.2302091118614458 0.8539929167213332 1.0544646405813423 1.0 13.185182966817008 -3.7304584237924607 0.8264603815430617 1.0647424617279972 6.256837307282661e-10 0.2490624399848932 0.10130332936167606 18.10897332493545 2.570229105532659 0.03809834350267386 26.436755099748407 0.00018601226293643138 3.7304584237924607 -1.0647424611023135 GS(ph)LPSGTTIEWLEPK ddPTM_A459_Selumetinib_30min_R1 1 GSLPSGTTIEWLEPK 15 0 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 GS(0.831)LPS(0.11)GT(0.006)T(0.053)IEWLEPK 125.36 0.0012365 24658000.0 3668.1 4429.2 3363.3 2974.6 2803.9 3834.4 3330.5 4079.1 2181.2 3299.4 True False 3753.5595931198695 3910.627204920782 2906.582333284484 2455.1419501574983 2550.2877400687535 3795.829417356643 3079.2777035990684 3970.9090172158417 3701.337091455099 3722.91012887756 1.0082326629387506 1.050422134713152 0.7807285786296444 0.6594684978059656 0.685025330127336 1.0195866367854192 0.8271157769063462 1.0666142559860965 0.9942053295202791 1.0 11.862215074585704 -7.758547140893592 24.956926993111114 1.0228073609993145 0.8571911446805247 0.24206132501919475 0.1285565007567467 114.7241871711557 989975.5263892632 0.07081949440869897 0.03857377838273619 1.7436240839152614e-08 7.758547140893592 -0.16561621631878976 GS(ph)LPSGTTIEWLEPK ddPTM_A459_Selumetinib_30min_R2 2 GSLPSGTTIEWLEPK 15 0 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 GS(0.976)LPS(0.006)GT(0.012)T(0.006)IEWLEPK;GS(0.994)LPS(0.006)GTTIEWLEPK 209.53 1.3801e-06 5022000.0 38654.0 29006.0 34797.0 36743.0 38887.0 35370.0 38136.0 37784.0 30817.0 33346.0 True False 36505.765424222045 31230.666931009913 32558.198904108987 31738.540014789633 34001.667405809145 40241.896443108075 39909.399565050415 37893.94518452209 36981.26109892322 32383.21433668704 1.1273051848612987 0.9644091104207836 1.005403557707479 0.9800923306996411 1.0499781477000742 1.2426776423339145 1.2324100736299342 1.1701724476928137 1.1419885844076645 1.0 14.982958573264124 -6.617915336489463 6.052616124108857 1.1721140881713918 1.0145044698979535 0.43558702663831883 0.07467659591152899 0.1715567212421481 9.069017381787706 0.024067985068262156 0.024039563532337722 2.410375273344679e-07 6.617915336489463 -0.15760961827343833 GS(ph)LSNAGDPEIVK ddPTM_A459_Selumetinib_30min_R2 1 GSLSNAGDPEIVK 13 0 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 GS(0.976)LS(0.024)NAGDPEIVK 79.337 0.039288 2998000.0 17720.0 13913.0 13970.0 23685.0 19344.0 20511.0 20654.0 16858.0 16753.0 16017.0 True False 16735.193338780326 14980.082362653973 13071.185409385944 20459.062141096045 16913.833782445854 23336.20406968021 21614.451925124584 16907.05398900786 20104.06811793038 15554.547592836218 1.075903573466056 0.9630676992208491 0.8403449429417023 1.3153106523341536 1.0873883461731582 1.5002817619991662 1.3895905230364467 1.0869524740658194 1.2924881291429835 1.0 13.9250488139548 -5.768377103878766 24.99998096068865 1.253343720658625 0.9601016229495557 0.4112265533891172 0.15234326654602157 145.973518497477 526014.925066124 0.042700595673322635 0.06491803125328198 1.7046016171527438e-06 5.768377103878766 -0.2932420977090694 GS(ph)MESLALSNATGLSADGGAK ddPTM_A459_Selumetinib_30min_R2 1 GSMESLALSNATGLSADGGAK 21 0 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 GS(0.995)MES(0.004)LALSNATGLS(0.001)ADGGAK 230.71 1.1382999999999997e-54 0.0 9662.3 8946.7 8929.1 7781.7 9403.3 8411.0 8802.9 8739.4 6540.1 7974.2 True False 9125.30804725153 9632.88312182536 8354.611427269005 6721.819035818754 8221.973387431406 9569.538902544022 9212.252292615432 8764.830207114444 7848.30274566206 7743.964126540207 1.178376849135595 1.2439214547509883 1.0788546138322077 0.8680075121708861 1.0617266884350562 1.235741636476231 1.1896042055570855 1.1318273256297138 1.0134735411240172 1.0 12.918856554089881 -8.55906400819444 0.012310911809896534 2.2786620325388487e-06 2.1578500780828 0.09984393148802473 0.10714881153803361 3479.8125971935747 27.243377847580593 2426.7537967636345 2343.3239595117243 2.760171020327156e-09 8.55906400819444 2.1578477994207677 GS(ph)MGNSIMRPNS(ph)S(ph)ASK ddPTM_A459_Selumetinib_30min_R2 1 GSMGNSIMRPNSSASK 16 1 Q96JM2;Q96JM2-3 Q96JM2 ZNF462 Zinc finger protein 462 3 GS(0.905)MGNS(0.101)IMRPNS(0.989)S(0.888)AS(0.116)K 52.69300000000001 0.04298 0.0 806.21 718.73 2109.2 2512.0 2755.7 1896.1 819.87 1250.9 1000.2 928.22 True False 761.4040757143384 773.8542799188018 1973.4963683233245 2169.861266558299 2409.504329729426 2157.2705639179303 857.9955795415842 1254.5399119023575 1200.267947922997 901.419876794808 0.8446719395867708 0.8584837098005947 2.18931978218687 2.4071593298715652 2.6730099832022076 2.393191696181106 0.9518267808697227 1.3917375733527684 1.3315303764887099 1.0 9.81605545238306 -7.272757221183852 24.801446043812017 1.2014184675829016 1.9193401058448634 0.26179520010530166 0.5949583528782627 1141.9551649505133 2502422.5251350896 0.28523348405524973 0.19427467072502572 5.3363312311480954e-08 7.272757221183852 0.7179216382619618 GS(ph)NRSSLMDTADGVPVSSR ddPTM_A459_Selumetinib_30min_R1 2 GSNRSSLMDTADGVPVSSR 19 1 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 GS(0.967)NRS(0.008)S(0.024)LMDT(0.001)ADGVPVSSR;GS(0.973)NRS(0.025)S(0.002)LMDTADGVPVSSR 90.872 0.0014282 19057300.0 2067.11 2457.11 3097.7 2838.6 2547.5099999999998 1943.86 2114.56 2032.1 1139.4 1702.81 True False 2115.269641104116 2169.43041892055 2677.0493544481133 2342.891797121321 2317.0881702994193 1924.3065332836659 1955.0570367579776 1978.202106808931 1933.4785815165699 1921.3822502739902 1.1009103684612875 1.1290988134251725 1.3932934761244746 1.2193782870572596 1.2059485664390837 1.0015219683690004 1.017526333700223 1.0295723854672012 1.0062956401522158 1.0 10.90792884984707 -6.7499893173494465 8.72695995244915 1.0131212039913033 1.2162487553296977 0.6502223232528861 0.07279828711555332 0.10463748992438104 57.04325246192269 0.02622085617972063 0.02526940714909077 1.7783231521815368e-07 6.7499893173494465 0.20312755133839433 GS(ph)PATSPHLGR ddPTM_A459_Selumetinib_30min_R1 2 GSPATSPHLGR 11 0 E9PNR2;Q13671-2;Q13671 E9PNR2 RIN1 Ras and Rab interactor 1 1 GS(0.991)PAT(0.009)SPHLGR;GS(0.987)PAT(0.013)SPHLGR 106.58 0.007302800000000002 20453000.0 5289.0 6315.9 3789.3999999999996 4566.0 6611.8 5177.5 7031.1 5719.8 2062.8 4423.9 True False 5412.223409397502 5576.431491817749 3274.820293684244 3768.633814435266 6013.7638574081 5125.41905079387 6500.738466228914 5568.092323471151 3500.4209390489527 4991.750657435124 1.0842335246325039 1.1171294150102937 0.656046449116295 0.7549723680252244 1.2047404347912902 1.0267778586175274 1.3022963109237398 1.1154588250872621 0.7012411434924415 1.0 12.285330156709607 -6.26461066127839 24.974154853090358 1.0748038311552133 0.9007372267351526 0.12916593474934435 0.19477110575766746 568.9620503053208 4480626.215885467 0.06281881988803105 0.07419374767845342 5.437375659239964e-07 6.26461066127839 -0.17406660442006072 GS(ph)PATSPHLGR ddPTM_A459_Selumetinib_30min_R2 2 GSPATSPHLGR 11 0 E9PNR2;Q13671-2;Q13671 E9PNR2 RIN1 Ras and Rab interactor 1 1 GS(0.999)PAT(0.001)SPHLGR;GS(0.999)PAT(0.001)SPHLGR 106.54 0.007316 44028000.0 66921.0 53441.0 84700.0 91378.0 94436.0 87149.0 76648.0 86473.0 79431.0 75801.0 True False 63201.7987259886 57539.75286010138 79250.49421438723 78932.15876415758 82572.10541144836 99152.98369014486 80212.28387513063 86724.62211362431 95319.419487574 73612.42817534991 0.8585751114667421 0.7816581287474677 1.076591224862289 1.0722667451769923 1.1217141922659564 1.3469598293097407 1.089656812896586 1.1781247306098943 1.294882153058673 1.0 16.167661740305512 -5.471370047818401 1.3921184023074569 1.1815692501128854 0.792078469711072 0.6290050714027091 0.10070698403035874 0.3051114915041288 1.0606578912380202 0.030878486730138714 0.11589955854439878 3.3777690513932128e-06 5.471370047818401 -0.3894907804018134 GS(ph)PDGSLQTGKPSAPK ddPTM_A459_Selumetinib_30min_R2 5 GSPDGSLQTGKPSAPK 16 1 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 GS(0.5)PDGS(0.5)LQT(0.001)GKPSAPK;GS(0.998)PDGS(0.002)LQTGKPSAPK;GS(0.892)PDGS(0.107)LQT(0.001)GKPSAPK;GS(0.988)PDGS(0.012)LQTGKPSAPK;GS(0.882)PDGS(0.091)LQT(0.022)GKPS(0.005)APK 155.63 0.00042552 127622200.0 161470.9 118774.09999999999 145436.5 154306.1 163402.0 122777.5 148341.2 167565.90000000002 121515.3 125824.9 True False 152496.99379722684 127883.69155107446 136079.27392928867 133289.34298713037 142873.97992758555 139688.98616182356 155239.35973251148 168053.48902697212 145821.75542116322 122192.00820464837 1.2480111918761772 1.0465798330844485 1.113651178409162 1.0908188264153582 1.1692579737972617 1.1431924903621444 1.2704542794035685 1.3753230796036553 1.1933821005457208 1.0 16.898790405251752 -7.172120292512039 5.163201409098607 1.2407254694062808 1.1284085842912872 0.08268431055864855 0.10178233788018427 0.35115946916183893 15.346432189381037 0.03812680045163821 0.029215540395527883 6.727902785027486e-08 7.172120292512039 -0.1123168851149936 GS(ph)PDGSLQTGKPSAPKK ddPTM_A459_Selumetinib_30min_R1 2 GSPDGSLQTGKPSAPKK 17 2 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 GS(0.974)PDGS(0.025)LQT(0.001)GKPSAPKK;GS(0.927)PDGS(0.056)LQT(0.017)GKPSAPKK 96.379 0.006800700000000001 72689000.0 6541.4 6775.3 9318.5 8962.9 8068.6 7179.200000000001 7192.700000000001 7900.3 4418.9 6690.6 True False 6693.801892651318 5982.044726248482 8053.098882856554 7397.697769470398 7338.796554627032 7106.983766192058 6650.1488481240085 7690.758380208953 7498.550556313465 7549.403681962844 0.8866663083130998 0.7923863894761489 1.0667198658480996 0.9799049144961074 0.9721028128567296 0.9413967070236524 0.8808839914088381 1.0187239554541025 0.9932639546391091 1.0 12.882146976907576 -5.250259735139297 24.998256786808824 0.9768571792996138 0.8395263439373319 0.5567369097095658 0.050574158313704834 560.0191825597118 1252225.6819371914 0.013228730881576355 0.034285827087032664 5.620051106152323e-06 5.250259735139297 -0.13733083536228186 GS(ph)PEEELPLPAFEK ddPTM_A459_Selumetinib_30min_R1 3 GSPEEELPLPAFEK 14 0 Q5JTD0-4;Q5JTD0-2;Q5JTD0 Q5JTD0-4 TJAP1 Tight junction-associated protein 1 1 GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK 275.83 3.2546999999999996e-45 109965000.0 8915.74 10256.390000000001 9048.4 10008.48 9571.84 8970.390000000001 9262.300000000001 8314.74 4473.719999999999 7477.759999999999 True False 9123.459394989923 9055.567090733653 7819.6769793034555 8260.68685043781 8706.06876204561 8880.156021062454 8563.637253879495 8094.206085118103 7591.576092419086 8437.60333555055 1.08128564856203 1.0732392517884086 0.9267651806237968 0.9790323770771104 1.0318177349442255 1.0524500462882957 1.014937170345271 0.9593015650563241 0.8997313325258066 1.0 13.042617550545323 -7.794394900952194 4.201384441163336 0.9442986254735246 1.0212369899366975 0.3051399886411664 0.04820136295533819 0.27005180357247993 10.402392208819558 0.029063008283031683 0.01387276390975114 1.6054807366259417e-08 7.794394900952194 0.07693836446317293 GS(ph)PEEELPLPAFEK ddPTM_A459_Selumetinib_30min_R2 6 GSPEEELPLPAFEK 14 0 Q5JTD0-4;Q5JTD0-2;Q5JTD0 Q5JTD0-4 TJAP1 Tight junction-associated protein 1 1 GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK;GS(1)PEEELPLPAFEK 180.95 3.3849e-05 20979700.0 131941.5 120253.84000000001 137025.06 141181.1 149829.1 112635.35 110041.9 119686.29999999999 103737.4 129472.6 True False 124608.71963367298 129476.92285096066 128209.01682120474 121951.9906290179 131006.22896885134 128149.84706059475 115159.06639388816 120034.56731786631 124487.77866513426 125734.3896277856 0.9910472385681837 1.0297653906322222 1.0196813870950092 0.969917545947733 1.0419283805860282 1.0192107938008026 0.9158915610502122 0.9546677537721175 0.9900853619575225 1.0 16.940019769858836 -7.226902053505211 24.98745059624029 0.9613834670213479 1.0125429578047165 0.39451034963720066 0.02822087083690231 575.555426375043 416409.65426249267 0.010692504271968826 0.008281930389443668 5.930590621911219e-08 7.226902053505211 0.051159490783368566 GS(ph)PEPSALPPQR ddPTM_A459_Selumetinib_30min_R2 2 GSPEPSALPPQR 12 0 O00562-2;O00562 O00562-2 PITPNM1 Membrane-associated phosphatidylinositol transfer protein 1 1 GS(0.999)PEPS(0.001)ALPPQR;GS(0.999)PEPS(0.001)ALPPQR 139.76 0.0011311 37767000.0 120771.0 86261.0 129783.0 114247.0 127183.0 104958.0 119005.0 109766.0 93049.0 98172.0 True False 114059.03130461826 92876.94132716826 121432.9030770462 98686.36151293216 111205.13450955383 119415.01178613899 124538.96830393387 110085.40088726034 111661.4000062859 95337.51927851117 1.1963708744236947 0.974190875009504 1.273715783628711 1.0351261734075328 1.1664362084426416 1.2525500211232665 1.3062954568821534 1.1546912665691031 1.1712220000196092 1.0 16.540756465926705 -5.267383816869519 24.99323415411123 1.1784003482171175 1.0852808762928952 0.0912717191814415 0.10427526839900664 941.931100637488 3960343.406972034 0.02652347338524952 0.05761287325804364 5.402766310718549e-06 5.267383816869519 -0.09311947192422232 GS(ph)PETNHLIR ddPTM_A459_Selumetinib_30min_R2 1 GSPETNHLIR 10 0 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 GS(1)PETNHLIR 155.47 0.00034716 10052000.0 19251.0 15534.0 18521.0 19471.0 22360.0 18446.0 17126.0 16913.0 18154.0 16746.0 True False 18181.106487858917 16725.40785031746 17329.379024140086 16819.016210651524 19550.936899063752 20986.769063883843 17922.3929345252 16962.214029902112 21785.307265141073 16262.499468666741 1.1179773762876237 1.0284647745903153 1.0656036642786013 1.0342208615014583 1.2022098409123951 1.2905008301042185 1.1020687790986008 1.0430262618967967 1.3396038725237303 1.0 13.989261389356356 -6.258701092626823 24.95151767308317 1.1683912321866772 1.0594906022666892 0.19819987726006139 0.0994475283293927 378.1569708997666 3445803.862543035 0.029332130576902246 0.03619564541687288 5.511869256132861e-07 6.258701092626823 -0.10890062991998795 GS(ph)PGEEWAPEVGEDAPQR ddPTM_A459_Selumetinib_30min_R1 1 GSPGEEWAPEVGEDAPQR 18 0 Q9NZ56 Q9NZ56 FMN2 Formin-2 1 GS(1)PGEEWAPEVGEDAPQR 142.4 0.00030177 1635500.0 435.19 362.29 377.21 441.11 406.28 269.96 299.83 266.82 143.93 332.17 True False 445.32908026766864 319.8729183759486 325.98695386621444 364.0784191602145 369.5320457345601 267.2444475040684 277.21358170548206 259.7430668464933 244.23869776872013 374.80725510979585 1.1881549094806454 0.8534331019879676 0.8697455810206235 0.9713750579709604 0.985925540919184 0.7130183417228194 0.7396163706176799 0.6930043730621072 0.6516381271679839 1.0 8.550005069158216 -6.761248396582056 24.99999999917283 0.7390282510920552 0.9611364830997138 0.4260500490131083 0.12277922365848612 4.802013397381072 628616.4758804041 0.04044050639767791 0.038039342898229134 1.7328126246965433e-07 6.761248396582056 0.2221082320076586 GS(ph)PGGPEFLK ddPTM_A459_Selumetinib_30min_R1 1 GSPGGPEFLK 10 0 Q4VC44-2;Q4VC44;Q4VC44-4;I3L188 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 GS(1)PGGPEFLK 88.948 0.031531 3401100.0 1552.2 1618.0 1896.0 1788.8 1636.3 1319.1 1449.0 1382.2 804.51 1296.1 True False 1588.3632399445648 1428.563807812207 1638.53361398251 1476.419659934691 1488.2969539122284 1305.831051646972 1339.7007634034078 1345.5395659816481 1365.1947109144244 1462.4670600831078 1.0860847969145389 0.9768177669116361 1.120390098830258 1.0095404540945971 1.0176618636645758 0.892896043465598 0.9160553423523101 0.9200477759172129 0.9334874939589028 1.0 10.514188415142794 -6.6246563913642795 4.413588583981563 0.9267633514663796 1.044786709944942 0.600940877039509 0.04492067396577037 0.14176984689999086 4.881426315685193 0.01449905002030373 0.01447859885679398 2.3732506507818592e-07 6.6246563913642795 0.11802335847856238 GS(ph)PGGPEFLK ddPTM_A459_Selumetinib_30min_R2 1 GSPGGPEFLK 10 0 Q4VC44-2;Q4VC44;Q4VC44-4;I3L188 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 GS(1)PGGPEFLK 80.737 0.046835 3419200.0 24789.0 22357.0 28726.0 29336.0 28235.0 23466.0 27639.0 25865.0 19373.0 22906.0 True False 23411.326618229414 24071.710010914587 26877.80043450399 25340.38619257733 24687.86687589737 26698.228496861015 28924.268265639497 25940.262867818754 23248.14132684686 22244.644263064634 1.0524477865938255 1.082135085022854 1.2082818730049247 1.1391679674847808 1.1098341957704174 1.2002092809904443 1.300280099945937 1.1661352081449279 1.0451118503813723 1.0 14.441170406630638 -5.090692846714397 5.728267129943263 1.1577680119950933 1.0591397454094236 0.124187196921978 0.08064565514961844 0.35954036115362864 17.646555141734517 0.020737485084229658 0.05825610258830189 8.11534810154099e-06 5.090692846714397 -0.0986282665856697 GS(ph)PGGYLGAK ddPTM_A459_Selumetinib_30min_R1 2 GSPGGYLGAK 10 0 O60551 O60551 NMT2 Glycylpeptide N-tetradecanoyltransferase 2 1 GS(1)PGGYLGAK;GS(1)PGGYLGAK 139.31 0.0015418 31244000.0 6560.8 8372.5 4664.200000000001 4820.0 6054.6 5835.4 8752.0 8790.599999999999 4744.7 9010.3 True False 6713.653874905486 7392.2438077303495 4030.82725861668 3978.277482605779 5506.962499026453 5776.701174119278 8091.82959372438 8557.444732106978 8051.409360822946 10166.859772754282 0.6603468548761842 0.7270921378831738 0.3964672818069858 0.39129854955479854 0.541658154249783 0.5681893232756101 0.7959025475505541 0.8416998880066878 0.7919268624516256 1.0 13.311586523852919 -7.316279960245415 2.4529092724224073 0.8627230111597344 0.5361553509913901 0.6679994700622301 0.10806712393739142 0.20726517343408032 2.445770851385665 0.057649254127540295 0.03660224049865205 4.827475070852776e-08 7.316279960245415 -0.32656766016834426 GS(ph)PGGYLGAK ddPTM_A459_Selumetinib_30min_R2 3 GSPGGYLGAK 10 0 O60551 O60551 NMT2 Glycylpeptide N-tetradecanoyltransferase 2 1 GS(1)PGGYLGAK;GS(1)PGGYLGAK;GS(1)PGGYLGAK 119.34 0.0054321000000000005 79114000.0 210327.0 153035.0 193665.0 226279.0 244186.0 226532.0 275621.0 262716.0 259437.0 192469.0 True False 198637.86734569128 164772.29241491776 181204.8047465088 195459.4098469529 213509.17162946274 257734.72674724789 288437.9226326504 263480.46006502485 311331.64927544433 186911.91987548172 1.0627351507491938 0.8815504785606338 0.9694662858699706 1.0457300421351694 1.1422983176872816 1.3789100605191333 1.5431756456453072 1.409650386345355 1.6656596833570028 1.0 17.511999050993893 -6.6021967860129696 1.8957636218302345 1.4444198360275973 0.9742402191918463 0.5723799579540558 0.16673375047186242 0.21563685322092438 1.581813721471865 0.06056805415578441 0.06216283268630267 2.499212670497339e-07 6.6021967860129696 -0.47017961683575094 GS(ph)PHLSGAGDTSISDR ddPTM_A459_Selumetinib_30min_R2 1 GSPHLSGAGDTSISDR 16 0 A0A2R8Y4Z8;Q9Y3X0 A0A2R8Y4Z8;Q9Y3X0 CCDC9 Coiled-coil domain-containing protein 9 1 GS(1)PHLSGAGDTSISDR 76.156 0.045444 0.0 9199.9 8833.7 10085.0 11371.0 13754.0 9347.1 10249.0 8516.4 7463.3 12551.0 True False 8688.606388117661 9511.216385177635 9436.14207971777 9822.250183930888 12026.099557679921 10634.57818047428 10725.59880800822 8541.181314034086 8956.168542025298 12188.620018585714 0.7128457835972336 0.7803357862230947 0.7741764092513467 0.805854163059765 0.9866662131842674 0.8725005918847444 0.8799682647956357 0.7007504788081126 0.7347975840061106 1.0 13.573247174495112 -5.883564410105314 3.860056168522206 0.8521036460832758 0.7578471247916354 0.21383956833310847 0.09004515485092521 0.4304095784439086 11.985009418793402 0.02779222261878434 0.04312926279545934 1.3074816122711018e-06 5.883564410105314 -0.09425652129164042 GS(ph)PHY(ph)FSPFRPY ddPTM_A459_Selumetinib_30min_R2 3 GSPHYFSPFRPY 12 1 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 2 GS(1)PHY(0.816)FS(0.184)PFRPY;GS(1)PHY(0.833)FS(0.167)PFRPY;GS(1)PHY(0.724)FS(0.276)PFRPY 84.29700000000003 0.031305 0.0 11678.7 11353.300000000001 11171.4 14676.9 14180.2 10876.2 10977.8 11765.4 11076.5 13622.0 True False 11029.64460754028 12224.06160338672 10452.644286500654 12677.880900935303 12398.756503403574 12374.297825686514 11488.28945209803 11799.63536613318 13292.109503268422 13228.697465793532 0.8337664865388665 0.9240563279185592 0.7901491672576886 0.9583619954812242 0.9372620800697876 0.935413169564403 0.8684369327973666 0.891972576789545 1.0047935208767802 1.0 13.691383396407849 -1.5228789551875137 0.05023072112351559 1.1867914403552196 0.40216025242440345 0.38448599461702515 0.05147256174328958 560.5330827423112 2.1329875272983285 7.83119726546782 34.07757270122855 0.029999985500129462 1.5228789551875137 -0.7846311879308161 GS(ph)PHYFS(ph)PFRPY ddPTM_A459_Selumetinib_30min_R1 2 GSPHYFSPFRPY 12 1 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 2 GS(1)PHY(0.069)FS(0.931)PFRPY;GS(1)PHY(0.001)FS(0.999)PFRPY 122.96 0.006736700000000001 83985000.0 10024.3 11454.5 11305.900000000001 11733.2 11220.1 10186.0 10997.8 9968.2 5675.2 8945.5 True False 10257.846686107658 10113.401814947418 9770.620878863328 9684.216879441934 10205.243936069543 10083.538088148023 10168.227091620418 9703.810954723092 9630.399899791848 10093.742061548835 1.0162580560864503 1.0019477170388051 0.9679879691084631 0.9594278138266531 1.0110466340273805 0.9989890792395336 1.0073793276683112 0.9613690240499458 0.9540960964792189 1.0 13.301173504716395 -7.771465164249959 24.980968705427244 0.9682994155506345 0.9934041929982844 0.20071612850100107 0.020464880831636046 328.4728076355965 818434.4820123384 0.011584887639542157 0.005669331267119247 1.6925240001985983e-08 7.771465164249959 0.02510477744764994 GS(ph)PHYFSPFRPY ddPTM_A459_Selumetinib_30min_R1 2 GSPHYFSPFRPY 12 1 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 GS(1)PHYFSPFRPY;GS(1)PHYFSPFRPY 141.73 0.00053222 1745160000.0 3042.7 4099.8 3761.5 4794.299999999999 3798.1 3287.9 3818.6 3098.0 1496.83 2306.2 True False 3113.588989936432 3619.793510054689 3250.7089604405123 3957.0655051570293 3454.5625256090184 3254.8267111743435 3530.5599276275043 3015.8309762777776 2540.0111858622486 2602.223234290304 1.1965111020867474 1.3910388095669677 1.249204494681667 1.5206479801630959 1.327542725807369 1.2507868918717198 1.3567475230811175 1.158943989330829 0.976092731934652 1.0 11.345529015045662 -8.010057253115022 2.6208124927694225 0.9870207950146038 1.3321997017239515 0.716177488508982 0.08568890009654688 0.1500816297897787 1.9542719221478644 0.06615123671922943 0.023070909401447653 9.7710840009907e-09 8.010057253115022 0.3451789067093477 GS(ph)PHYFSPFRPY ddPTM_A459_Selumetinib_30min_R2 7 GSPHYFSPFRPY 12 1 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 GS(1)PHYFSPFRPY;GS(1)PHYFSPFRPY;GS(0.999)PHYFS(0.001)PFRPY;GS(1)PHYFSPFRPY;GS(1)PHYFSPFRPY;GS(0.986)PHY(0.013)FS(0.001)PFRPY;GS(0.761)PHY(0.238)FS(0.002)PFRPY 135.1 0.0072077 1564866800.0 171262.04 143164.39 186561.5 207854.02 193238.2 162109.7 138114.69 158362.76 149459.87 183550.9 True False 161743.98143306584 154144.63836693155 174558.33620280275 179543.94390781617 168961.8897445736 184438.83968966128 144537.29675406634 158823.56941323393 179356.0202576865 178251.3085944887 0.9073929538493539 0.8647602061514262 0.979282214415114 1.0072517577768145 0.9478858308353404 1.034712402079745 0.8108624721677652 0.8910092759798373 1.0061974953895623 1.0 17.44355314238704 -3.7696800736483214 0.006658992243930225 1.8398414987618097 4.951847356853989e-07 0.06415141288704329 0.0674667971034349 81238.64521836472 64.39866760293549 8342.345769671252 9480.641683218242 0.00016994951375383222 3.7696800736483214 -1.839841003577074 GS(ph)PLAEGPQAFFPER ddPTM_A459_Selumetinib_30min_R2 1 GSPLAEGPQAFFPER 15 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 GS(1)PLAEGPQAFFPER 83.25200000000002 0.02384 1526300.0 4328.8 3747.5 3425.3 5650.2 5158.5 3530.3 3739.3 1332.8 4448.7 4620.5 True False 4088.2226255593796 4034.9211998882865 3204.9199271846574 4880.633012861345 4510.443112424882 4016.566780127348 3913.184859282381 1336.6782273430817 5338.564307063629 4487.094159499267 0.9111069391990653 0.8992281098773642 0.7142528802075121 1.0877046122441956 1.005203579888375 0.8951376185463361 0.8720977809208864 0.29789395538163765 1.1897598127647449 1.0 12.13156574325119 -7.538195572250796 24.99993489439787 0.7632954504658314 0.917147005955195 0.0060409243037268245 0.23094400049133562 637.2841064178609 1040154.4066831312 0.10322623613959198 0.05962196333280997 2.8960391446002196e-08 7.538195572250796 0.1538515554893637 GS(ph)PLLGPVVPGPSPIPSVTEK ddPTM_A459_Selumetinib_30min_R1 1 GSPLLGPVVPGPSPIPSVTEK 21 0 P49454 P49454 CENPF Centromere protein F 1 GS(1)PLLGPVVPGPSPIPSVTEK 159.06 1.2865e-07 6986600.0 2447.8 3253.4 1678.9 2202.4 2211.3 2064.9 2609.6 2500.3 1247.1 2695.0 True False 2504.828977410326 2872.4904155353734 1450.914601537573 1817.7921841682496 2011.2883054367244 2044.128980779193 2412.755770998986 2433.9839218809966 2116.2376154197937 3040.9295015230123 0.8237050468140787 0.9446093420109614 0.47712865451530534 0.5977751813246018 0.6614057657138698 0.6722053174055551 0.7934270655701117 0.8004078755071321 0.6959180126865493 1.0 11.570296655130736 -9.663697172507993 0.5642071539724337 1.025303597643517 0.7025644255177167 0.31697416463503625 0.12385159063802242 7.275693641385744 2.474299967857302 0.5535139920098004 0.058544474987222046 2.1692161417932578e-10 9.663697172507993 -0.3227391721258003 GS(ph)PLLGPVVPGPSPIPSVTEK ddPTM_A459_Selumetinib_30min_R2 2 GSPLLGPVVPGPSPIPSVTEK 21 0 P49454 P49454 CENPF Centromere protein F 1 GS(1)PLLGPVVPGPSPIPSVTEK;GS(1)PLLGPVVPGPSPIPSVTEK 137.13 3.0877e-05 8051300.0 43621.0 36508.0 41645.0 46540.0 47063.0 39059.0 42178.0 47041.0 38825.0 49996.0 True False 41196.71944869842 39308.04620827797 38965.606039647646 40201.171714021955 41150.52519144176 44439.022707700235 44139.36057412143 47177.881521943236 46591.08486113817 48552.48557479174 0.8484986702737954 0.8095990502427862 0.8025460607907258 0.8279941024254018 0.8475472409759996 0.9152780168019411 0.9091060952199409 0.9716882866742008 0.9596024654467553 1.0 15.567257533785803 -7.138762703938763 0.8115023268174376 0.987154467883365 0.8137771087627202 0.9277046129717864 0.01825535314656925 0.15245444736973687 0.2022233625142351 0.014076431015595572 0.009369935586418536 7.265028060527189e-08 7.138762703938763 -0.17337735912064478 GS(ph)PLNAAPYGIESMSQDTEVR ddPTM_A459_Selumetinib_30min_R2 1 GSPLNAAPYGIESMSQDTEVR 21 0 B4DSN5;P18031 B4DSN5 PTPN1 Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 1 1 GS(0.998)PLNAAPY(0.002)GIESMSQDTEVR 102.07 0.00096869 0.0 3832.8 2880.8 2446.3 4045.8 3524.1 3305.9 7572.9 4926.2 4575.8 3224.4 True False 3619.788319914065 3101.7480967680267 2288.9077213300534 3494.7550606057157 3081.37105214627 3761.257717027733 7925.054855416669 4940.534426423691 5491.087858534348 3131.303194002691 1.1560005836697507 0.9905614067359334 0.7309760759398652 1.1160704805906805 0.9840538782855475 1.2011796635444243 2.530912647039525 1.5777885820466626 1.7536110425369524 1.0 11.612547491416093 -7.019007481248076 23.830875683407548 1.77834425254664 0.9977913036140422 0.4645311307466262 0.3637945528046853 328.4435048629259 411789.3339861355 0.13056625437388705 0.10298663515412701 9.57177582610496e-08 7.019007481248076 -0.7805529489325977 GS(ph)PLPVLSWANR ddPTM_A459_Selumetinib_30min_R1 2 GSPLPVLSWANR 12 0 I3L413;C9J2U0;P24864-2;P24864-3;P24864;I3L1Q9 I3L413 CCNE1 G1/S-specific cyclin-E1 1 GS(1)PLPVLSWANR;GS(1)PLPVLSWANR 158.25 0.00045232 16188300.0 1619.48 2203.09 1196.39 1410.3 1660.99 1675.71 1975.28 1779.97 1003.95 1698.6999999999998 True False 1657.210733040475 1945.1511986112446 1033.9268092998614 1164.0175796097362 1510.753747771602 1658.853878822946 1826.2830392929475 1732.7594134425938 1703.6298243931546 1916.7446917391983 0.864596490175627 1.0148201828832357 0.5394181153890174 0.6072887978385586 0.7881872605583106 0.865453748729441 0.9528045373825095 0.9040115884553922 0.8888141606628531 1.0 10.904442469090492 -6.856203926063274 2.931403071694073 0.9267340048955159 0.754072852763657 0.3001119872415948 0.1251382739213765 0.38464053691904687 6.66447789229746 0.052400173356694425 0.0461348330898217 1.3925027898187184e-07 6.856203926063274 -0.17266115213185895 GS(ph)PLPVLSWANR ddPTM_A459_Selumetinib_30min_R2 1 GSPLPVLSWANR 12 0 I3L413;C9J2U0;P24864-2;P24864-3;P24864;I3L1Q9 I3L413 CCNE1 G1/S-specific cyclin-E1 1 GS(1)PLPVLSWANR 126.5 0.0027261 8976500.0 5448.4 3935.9 5700.4 5904.6 7124.8 6066.6 6435.8 6786.3 5784.5 4139.6 True False 5145.599739673286 4237.7708740868065 5333.642470126247 5100.383293996864 6229.718927479848 6902.219082888306 6735.07745229577 6806.047009467556 6941.5616324340945 4020.07899202752 1.2799747840472437 1.0541511454105765 1.326750663532667 1.2687271330020544 1.5496508749789266 1.7169361837358283 1.6753594806600913 1.6930132524671953 1.7267226953003552 1.0 11.973008134396323 -6.238341770015629 2.529973361130077 1.6163704557440852 1.2093784907829053 0.3500493426612613 0.21320806587795754 0.26980331042251676 3.4126812054352356 0.06554881902224048 0.08438081588271974 5.77641291054552e-07 6.238341770015629 -0.40699196496117995 GS(ph)PMMNR ddPTM_A459_Selumetinib_30min_R2 2 GSPMMNR 7 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 GS(1)PMMNR;GS(1)PMMNR 112.11 0.014704 7422200.0 27670.0 27692.0 26356.0 27315.0 35094.0 20945.8 20995.0 26330.0 21310.7 31094.0 True False 26132.212171786192 29815.887356185864 24660.283654243074 23594.64987899678 30685.17797565938 23830.89382295879 21971.30910080325 26406.61594083386 25573.43547070848 30196.23542808574 0.865412916587623 0.9874041228481709 0.8166674853550242 0.7813771996575184 1.0161921690118654 0.7892008220598751 0.7276174923569305 0.8745002668866754 0.8469080701007662 1.0 14.882081079173718 GS(ph)PNLTLPK ddPTM_A459_Selumetinib_30min_R2 2 GSPNLTLPK 9 0 Q12923-3;Q12923;Q12923-4;Q12923-2 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 GS(1)PNLTLPK;GS(1)PNLTLPK 106.16 0.013330000000000002 16521000.0 84170.0 76341.0 89344.0 91716.0 95015.0 75609.0 79802.0 80132.0 65070.0 92223.0 True False 79492.16835920644 82196.10922499599 83595.70431039204 79224.12258107509 83078.3662551226 86023.45343983473 83512.95112466313 80365.17085343324 78085.81820770793 89560.28236586976 0.8875828242084669 0.9177741187685206 0.9334015269055166 0.8845899151750146 0.9276251041252039 0.960508957401603 0.9324775326578114 0.8973304765289501 0.87187999127463 1.0 16.450571456279462 GS(ph)PNTASAEATLPR ddPTM_A459_Selumetinib_30min_R1 4 GSPNTASAEATLPR 14 0 Q6PJG6-3;Q6PJG6 Q6PJG6-3 BRAT1 BRCA1-associated ATM activator 1 1 GS(0.985)PNT(0.007)ASAEAT(0.007)LPR;GS(0.999)PNTASAEAT(0.001)LPR;GS(1)PNTASAEATLPR;GS(0.998)PNT(0.002)ASAEATLPR 145.46 0.0005166000000000001 72443900.0 4231.25 4877.49 4734.469999999999 4875.549999999999 4955.66 4298.41 4632.01 4448.5 2368.62 3584.2300000000005 True False 4329.82989242072 4306.431203316416 4091.554978582161 4024.1267179084207 4507.421427992833 4255.171898044016 4282.613756447355 4330.5113292355345 4019.3751428398937 4044.3008338567083 1.0706003510356392 1.0648147554369085 1.0116841319839183 0.9950117172838873 1.1145119053110808 1.0521403013401005 1.0589256171538028 1.0707688441430534 0.9938368355765846 1.0 11.981674600243991 -8.27043130581523 24.18340353264996 0.9969183975400129 1.0537487100179403 0.3566416311531887 0.03107431343008642 545.7221838521418 1467668.6922824394 0.029710822715541995 0.00811109065333168 5.3649872498905115e-09 8.27043130581523 0.05683031247792747 GS(ph)PNTASAEATLPR ddPTM_A459_Selumetinib_30min_R2 4 GSPNTASAEATLPR 14 0 Q6PJG6-3;Q6PJG6 Q6PJG6-3 BRAT1 BRCA1-associated ATM activator 1 1 GS(1)PNTASAEATLPR;GS(0.985)PNT(0.013)ASAEAT(0.002)LPR;GS(1)PNTASAEATLPR;GS(1)PNTASAEATLPR 176.49 6.9343e-05 59752000.0 49726.5 43884.4 50014.9 69890.0 64410.0 45818.8 42712.5 46680.1 23892.7 46384.0 True False 46962.90020095145 47250.19236941365 46796.99578610573 60370.8614330253 56318.23996729408 52129.923798345466 44698.7158832131 46815.93136269342 28671.907617816225 45044.77339989482 1.0425826717792106 1.048960596381288 1.0388995715586173 1.3402412061676898 1.250272467069966 1.157291287394226 0.9923174768000382 1.039319943893929 0.6365201876647286 1.0 15.45907209763053 -7.7859205139611705 1.8391901882685908 0.8355867416296815 1.145937456088928 0.44967233961005737 0.13118867544853616 0.330400619080264 2.1478970678066513 0.10137833886523977 0.039967798986998024 1.6371161245168852e-08 7.7859205139611705 0.31035071445924645 GS(ph)PPEDYR ddPTM_A459_Selumetinib_30min_R2 1 GSPPEDYR 8 0 H7C5M1;Q5TCT4;A2A2V2;P42696-2;P42696 H7C5M1 RBM34 RNA-binding protein 34 1 GS(1)PPEDYR 91.626 0.026601 14463000.0 62872.0 50589.0 61872.0 59529.0 71735.0 64251.0 65646.0 72610.0 68406.0 69018.0 True False 59377.82593655734 54469.01363072681 57891.222881140115 51421.04750674716 62723.00798096326 73100.9920374932 68698.66907508127 72821.28307876737 82089.11142333597 67025.2710097003 0.8859020641328526 0.8126638327630742 0.8637223245656366 0.767188953242803 0.9358113296085832 1.090648212775053 1.024966673616863 1.0864750262364211 1.2247486684754403 1.0 16.03241752715617 -6.60545358629005 3.182171287904314 1.0880859489254733 0.8334506094892556 0.7823975333454846 0.06299324302730962 0.11237497086785234 2.2892760003115744 0.021761725773821322 0.022016019915068057 2.4805410227088744e-07 6.60545358629005 -0.25463533943621763 GS(ph)PPTSSNIVQGQIK ddPTM_A459_Selumetinib_30min_R2 2 GSPPTSSNIVQGQIK 15 0 A2RRE0;Q9Y4E6-2;Q9Y4E6 A2RRE0 WDR7 WD repeat-containing protein 7 1 GS(1)PPTSSNIVQGQIK;GS(0.908)PPT(0.031)S(0.044)S(0.017)NIVQGQIK 179.14 1.9902e-05 16194600.0 30997.0 26156.0 34973.0 39916.0 39471.0 30994.0 32741.0 34840.0 26900.0 29785.0 True False 29274.31083082242 28162.081095204285 32722.875255723324 34479.371941059304 34512.30010478288 35263.14216448093 34263.52137506073 34941.378631927495 32280.751648798865 28925.02965927618 1.0120753954502593 0.9736232400429978 1.131299626696465 1.1920254653914195 1.1931638622785259 1.2191220745446023 1.1845630507096994 1.2079980225956963 1.116014470133707 1.0 14.820030818200062 -5.364984013643905 3.864833931193641 1.1720473075790803 0.9923712280648698 0.5196165965953816 0.06191725521694461 0.14966933101318644 3.9569807536689674 0.015505876390747984 0.03556078912934834 4.315349613137028e-06 5.364984013643905 -0.1796760795142105 GS(ph)PPVPSGPPMEEDGLR ddPTM_A459_Selumetinib_30min_R1 2 GSPPVPSGPPMEEDGLR 17 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 GS(0.991)PPVPS(0.009)GPPMEEDGLR;GS(1)PPVPSGPPMEEDGLR 162.79 1.4194000000000003e-05 25745000.0 1850.0900000000001 2386.2799999999997 1406.32 1426.87 1900.35 1800.21 2288.18 2304.87 966.03 1956.04 True False 1893.1934973515265 2106.8932282485234 1215.3494683628078 1177.6939401671584 1728.4636780340434 1782.1015218599007 2115.5807403757135 2243.737360327101 1639.2823539603753 2207.11678744307 0.8577677031512132 0.9545907313266124 0.5506502760874662 0.533589317460409 0.783131951996277 0.8074341747563134 0.9585268674552558 1.0165920412967617 0.742725696839755 1.0 11.107947255107511 -6.989958229629549 2.5857178014185425 0.9295995051867375 0.7259527439607459 0.30434198623258335 0.1375178179870785 0.3885916480906332 5.240905967192549 0.06119860583099964 0.049239693642142375 1.0233914171623443e-07 6.989958229629549 -0.20364676122599157 GS(ph)PPVPSGPPMEEDGLR ddPTM_A459_Selumetinib_30min_R2 1 GSPPVPSGPPMEEDGLR 17 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 GS(0.998)PPVPS(0.002)GPPMEEDGLR 85.473 0.011706 18122000.0 20782.0 16898.0 22440.0 24036.0 25260.0 14756.0 27084.0 24998.0 22272.0 20291.0 True False 19627.019636937493 18194.022264366195 20996.234830824666 20762.25533558727 22086.612972734816 16788.505058368755 28343.459665927858 25070.740041358313 26727.022331674674 19705.14610765059 0.9960352249972526 0.9233132383272359 1.065520383158834 1.0536463531993936 1.12085507268376 0.8519858196763413 1.4383785591380829 1.2722940446315447 1.3563473310810832 1.0 14.266284826208727 -7.262437412543114 24.999997266143918 1.289446152607677 1.0089728788058687 0.5082880912096163 0.12672442855204977 69.27422289310846 1735233.781958273 0.04835735734445852 0.0347169454009264 5.464652969308927e-08 7.262437412543114 -0.2804732738018083 GS(ph)PQAISR ddPTM_A459_Selumetinib_30min_R2 2 GSPQAISR 8 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 GS(1)PQAISR;GS(1)PQAISR 141.89 0.0022498 57712000.0 143978.0 115842.0 149382.0 154165.0 211015.0 140263.0 173279.0 222040.0 186852.0 159173.0 True False 135976.2791495999 124726.70890926216 139770.9247548239 133167.46105054163 184505.40920196509 159582.95506925843 181336.81684582448 222686.09963929944 224227.6210810918 154577.26190887907 0.8796654661262912 0.8068891075505442 0.904214002944474 0.8614945005885912 1.193612869858752 1.0323831144281113 1.1731144322683096 1.4406135604250092 1.4505860584674515 1.0 17.23796859095765 -6.6430660760292435 0.9126559290189732 1.3103010023517687 0.8371208076917133 0.6007405811079849 0.13996461711274086 0.3676827883219778 0.6690450456227351 0.08123460620530353 0.08517644366089018 2.2747513108575278e-07 6.6430660760292435 -0.47318019466005545 GS(ph)PQQIDHAK ddPTM_A459_Selumetinib_30min_R1 1 GSPQQIDHAK 10 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 GS(1)PQQIDHAK 106.58 0.0056675 0.0 3172.7 3415.4 3315.5 3951.4 4086.8 2927.0 3253.9 3501.0 1682.8 2434.1 True False 3246.6177370004625 3015.5233802236153 2865.2733107378776 3261.362166964411 3717.149661583141 2897.5570375033644 3008.455703270079 3408.14210714929 2855.5886931508517 2746.5404451418076 1.1820753423614103 1.0979351808044902 1.0432299716561937 1.1874437067669041 1.3533933819027448 1.054984295836124 1.095361879192989 1.2408854612637328 1.039703856610571 1.0 11.423399821585264 -8.450455319719682 6.45415167895992 1.0003058900272677 1.1530359539241266 0.2824904228207311 0.08829230273573181 0.2844079183476243 19.269283860388565 0.08825525728441513 0.022856262319608665 3.544415934086734e-09 8.450455319719682 0.15273006389685895 GS(ph)PQQIDHAK ddPTM_A459_Selumetinib_30min_R2 2 GSPQQIDHAK 10 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 GS(1)PQQIDHAK;GS(1)PQQIDHAK 101.43 0.010825 26942000.0 297040.0 253990.0 349170.0 431470.0 440300.0 305720.0 273990.0 299920.0 298860.0 335030.0 True False 280531.70594533306 273470.2162934288 326704.7823475507 372703.0416727345 384985.5776680576 347830.15495015576 286731.07790088526 300792.71754557115 358640.3508460977 325356.8133875208 0.8622278507848607 0.8405240186800953 1.0041430481998985 1.1455209368208967 1.183271908953433 1.069072908996892 0.8812819221934356 0.9245010559754523 1.1022985721799963 1.0 18.311663240362606 -5.327856523664398 4.4438580847296665 1.042547270695182 0.8503652436473903 0.4253988307093658 0.08781624854827662 0.21826825818951878 8.47951499709612 0.026605708237775704 0.06027295354563196 4.700493715092966e-06 5.327856523664398 -0.19218202704779164 GS(ph)PQSAAAELSSGLLASAAASSR ddPTM_A459_Selumetinib_30min_R2 1 GSPQSAAAELSSGLLASAAASSR 23 0 Q12948 Q12948 FOXC1 Forkhead box protein C1 1 GS(0.998)PQS(0.001)AAAELSSGLLASAAASSR 108.77 1.7604e-05 4819600.0 4907.9 4283.7 5379.5 7697.1 5891.8 3551.1 5593.4 3679.6 4752.0 5657.5 True False 4635.138565880359 4612.246015733543 5033.388826756742 6648.74170176189 5151.619410639704 4040.231791323751 5853.5041831118315 3690.307026809427 5702.532781973691 5494.153275049688 0.8436493002351558 0.8394825890058246 0.9161354943653662 1.2101485650128245 0.9376548401069342 0.7353693260927839 1.0654060580533937 0.6716789361461803 1.0379275015624894 1.0 12.423681443723387 -6.538997745448431 24.995441181952053 0.8856252709144009 0.9582293702869307 0.018330351109193233 0.15146389940599855 875.2526634916445 1357229.3126251902 0.049792959709307055 0.04980604894947356 2.890694888781748e-07 6.538997745448431 0.07260409937252976 GS(ph)PSGGSTAEASDTLSIR ddPTM_A459_Selumetinib_30min_R1 4 GSPSGGSTAEASDTLSIR 18 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 GS(0.994)PS(0.006)GGSTAEASDTLSIR;GS(0.874)PS(0.126)GGSTAEASDTLSIR;GS(0.967)PS(0.033)GGSTAEASDTLSIR;GS(0.766)PS(0.122)GGS(0.077)T(0.035)AEASDTLSIR 342.02 3.363399999999998e-163 36276800.0 3322.2200000000003 3673.11 2851.93 2877.03 3999.5899999999997 2576.06 3230.8999999999996 3377.63 1765.9 2709.9700000000003 True False 3399.6212620851925 3243.0605736174884 2464.653570530139 2374.6107190417647 3637.8277906849644 2550.1471752753373 2987.1906117874873 3288.0442803115257 2996.6033237669917 3057.8210468431607 1.1117790119192554 1.0605789298773929 0.8060162883222362 0.7765695515416999 1.1896797539674835 0.8339752837753743 0.9769017107366074 1.0752899629970312 0.9799799523456845 1.0 11.578288262849892 -7.53822642243578 23.70123572180598 1.0218001920074324 0.9574799157532791 0.0347489027150254 0.12820409647969064 495.96705142262795 765898.5163842196 0.06201083591933372 0.03582157664045416 2.895833431256237e-08 7.53822642243578 -0.06432027625415337 GS(ph)PSGGSTAEASDTLSIR ddPTM_A459_Selumetinib_30min_R2 5 GSPSGGSTAEASDTLSIR 18 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 GS(1)PSGGSTAEASDTLSIR;GS(1)PSGGSTAEASDTLSIR;GS(0.963)PS(0.029)GGS(0.004)T(0.005)AEASDTLSIR;GS(0.767)PS(0.232)GGSTAEASDTLSIR;GS(0.837)PS(0.157)GGS(0.006)T(0.001)AEASDTLSIR 254.59 1.7617999999999998e-33 43638000.0 42576.0 34656.8 42478.6 50132.2 52053.299999999996 36723.2 37490.899999999994 39708.4 36071.9 38003.2 True False 40209.796365231974 37314.865120824135 39745.57312320269 43304.10787713134 45513.89909159368 41781.4874599815 39234.301136808994 39823.94486992052 43287.28793309694 36905.94887182825 1.089520730245353 1.0110799548987623 1.0769421824442518 1.1733638939219107 1.2332401816753238 1.1321071192366752 1.0630888064432904 1.079065735668422 1.17290814235479 1.0 15.171565762668425 -5.550821297645506 9.220529205366905 1.1277314657051052 1.048702647029626 0.17118621304109716 0.06420202963955488 0.42465644832135396 131.21161338163776 0.01794103897625399 0.03135663780425496 2.8130581020577656e-06 5.550821297645506 -0.07902881867547928 GS(ph)PSPAAPGPPAGPLPR ddPTM_A459_Selumetinib_30min_R2 2 GSPSPAAPGPPAGPLPR 17 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 1 GS(0.647)PS(0.353)PAAPGPPAGPLPR;GS(0.98)PS(0.02)PAAPGPPAGPLPR 127.07 0.0011205 10590500.0 10470.9 10445.0 16468.6 15393.5 17379.4 9250.5 6956.5 10234.1 9414.8 14649.599999999999 True False 9888.969296333787 11246.09791403154 15409.028205655935 13296.87874473135 15196.044398192704 10524.672407321774 7279.991034043244 10263.879536653543 11298.023071491132 14226.627983768092 0.6951028246199051 0.7904963795259708 1.0831117692285837 0.9346472516117282 1.0681409829181356 0.7397868573867206 0.5117158501894735 0.7214555373461753 0.7941462365067562 1.0 13.796306132237458 -6.896505111127663 9.23578133847193 0.7183847613684273 0.9176299616533572 0.1947046631163145 0.1561412286188392 0.39635607254276667 32.24745152135841 0.05636971477261559 0.049722795125233095 1.2690972085979957e-07 6.896505111127663 0.19924520028492987 GS(ph)PSPASVSSGR ddPTM_A459_Selumetinib_30min_R1 2 GSPSPASVSSGR 12 0 P10398;Q96II5 P10398 ARAF Serine/threonine-protein kinase A-Raf 1 GS(0.998)PS(0.002)PASVSSGR;GS(0.996)PS(0.004)PASVSSGR 140.01 0.0011107 40516000.0 3270.2 3636.7 2788.1 3081.9 2982.0 2699.3 3356.1 3163.1 1416.2 3269.6 True False 3346.3892972984913 3210.913473344039 2409.491333937045 2543.704019427955 2712.2786265148616 2672.147492768305 3102.9466749883877 3079.204312803176 2403.187964844449 3689.285008600983 0.9070563237854802 0.87033489303708 0.6531052299618213 0.6894842804222803 0.7351773094763928 0.7242995557509427 0.8410699275752238 0.8346344361101133 0.6513966687967445 1.0 11.849125530624166 -9.613710929987604 8.048985987889925 0.9999999991409263 0.7666994561433778 0.3919394660327846 0.08691285539257348 11610502.62816726 1386758.2006178775 0.08853957581396382 0.0221348941088216 2.4338234431474817e-10 9.613710929987604 -0.23330054299754854 GS(ph)PSPASVSSGR ddPTM_A459_Selumetinib_30min_R2 3 GSPSPASVSSGR 12 0 P10398;Q96II5 P10398 ARAF Serine/threonine-protein kinase A-Raf 1 GS(0.998)PS(0.001)PASVSSGR;GS(0.999)PS(0.001)PASVSSGR;GS(0.985)PS(0.015)PASVSSGR 105.66 0.0092291 98609000.0 90896.0 56421.0 99109.0 95135.0 98082.0 73999.0 108342.0 99965.0 90212.0 75334.0 True False 85844.3642055179 60748.30927789114 92732.43484172045 82177.44888297113 85760.0622957947 84191.69055395968 113380.11767560034 100255.88159990332 108256.92073388273 73158.91167876149 1.173395861634162 0.8303610303094048 1.2675480363746483 1.123273255400651 1.172243549389642 1.1508056725015645 1.5497786267440516 1.3703850877405583 1.4797502894689782 1.0 16.15874599308151 -7.113553487670471 6.698513797763839 1.3801364059815933 1.1120058594921325 0.29752287420203183 0.17161105467514304 0.27211216704929353 14.259339185382096 0.06306001101700112 0.048815496985230696 7.699216150385243e-08 7.113553487670471 -0.2681305464894608 GS(ph)PSSHLLGADHGLR ddPTM_A459_Selumetinib_30min_R1 2 GSPSSHLLGADHGLR 15 0 F8VU11;Q6NWY9-2;Q6NWY9-3;Q6NWY9 F8VU11 PRPF40B Pre-mRNA-processing factor 40 homolog B 1 GS(0.999)PSSHLLGADHGLR;GS(0.608)PS(0.226)S(0.165)HLLGADHGLR 118.52 0.001333 23968000.0 2270.06 3109.14 2136.6 2578.48 3881.8999999999996 2640.35 3041.8 2743.39 809.92 1640.77 True False 2322.9479812321597 2745.120443400029 1846.4614555037087 2128.19687206418 3530.7828304051113 2613.790476245988 2812.354577032769 2670.6263854133917 1374.3750857836576 1851.3788119532142 1.254712415543655 1.4827437938019357 0.9973439490515085 1.1495199460659924 1.907109883514394 1.4118074914600678 1.5190595025043636 1.4425067242699332 0.742352173909609 1.0 10.854384400946534 -8.255772258622905 24.924837623011346 0.8711760699797687 1.3987332019315948 0.4403164890298995 0.23647915838321287 389.45284490389594 1712891.5548942871 0.17803569134441063 0.06309947139668981 5.5491663156985156e-09 8.255772258622905 0.5275571319518261 GS(ph)PSSHLLGADHGLR ddPTM_A459_Selumetinib_30min_R2 3 GSPSSHLLGADHGLR 15 0 F8VU11;Q6NWY9-2;Q6NWY9-3;Q6NWY9 F8VU11 PRPF40B Pre-mRNA-processing factor 40 homolog B 1 GS(0.879)PS(0.095)S(0.026)HLLGADHGLR;GS(0.457)PS(0.086)S(0.457)HLLGADHGLR;GS(0.552)PS(0.125)S(0.324)HLLGADHGLR 75.911 0.02499 64131000.0 99526.0 90055.0 156902.0 164511.0 205308.0 114645.0 97792.0 136775.0 135377.0 154907.0 True False 93994.74335414502 96961.9289275356 146807.09614198084 142104.318002696 179515.37356319235 130436.30810630824 102339.52177117189 137172.99260567987 162456.18274942157 150434.43241327867 0.6248220028239241 0.6445461146897437 0.9758875929326294 0.9446262781934266 1.1933130645916323 0.8670641821412873 0.6802932023568994 0.9118457151407564 1.0799135553163541 1.0 17.1987752926919 -5.256865164528856 22.690279611698546 0.9484276256971647 0.6346838826589936 0.5069859091644829 0.126781102606659 92.52424533981494 458945.73989585164 0.03531842697808545 0.08667904889035097 5.5352193457680075e-06 5.256865164528856 -0.3137437430381711 GS(ph)PTGGAQLLK ddPTM_A459_Selumetinib_30min_R1 1 GSPTGGAQLLK 11 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 GS(1)PTGGAQLLK 147.96 0.00065727 48766000.0 1961.4 2086.0 1826.7 2219.9 2514.0 1894.0 2178.7 2039.9 1033.5 1709.4 True False 2007.0968037799694 1841.77015024491 1578.644173344858 1832.236137683935 2286.60914388275 1874.9480796144069 2014.358904918566 1985.795225470962 1753.7740161465454 1928.8181409660262 1.0405837446005863 0.954869778092444 0.8184515376624425 0.9499268483478078 1.185497531010118 0.9720709484178539 1.044348796880196 1.0295398945576069 0.9092479891692578 1.0 10.913501409648514 -6.024046139472859 24.90966019485842 1.0274317957258878 0.9304135867716662 0.1913881041729102 0.08266269657739653 1085.2180855426805 1124188.4113474328 0.024593706612380126 0.03194305850938219 9.461366384105973e-07 6.024046139472859 -0.09701820895422164 GS(ph)PTGGAQLLK ddPTM_A459_Selumetinib_30min_R2 4 GSPTGGAQLLK 11 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 GS(1)PTGGAQLLK;GS(0.999)PT(0.001)GGAQLLK;GS(0.991)PT(0.009)GGAQLLK;GS(0.997)PT(0.003)GGAQLLK 168.82 0.00045689 237113000.0 316909.0 275153.0 313903.0 356732.0 361596.0 263098.0 334066.0 320536.0 285006.0 323633.0 True False 299296.466467242 296256.35034365964 293706.8227317448 308144.48620297527 316169.0777707451 299337.361334149 349600.7309392205 321468.7066924084 342015.1637329959 314288.8743904834 0.9522973635248242 0.9426243640288089 0.9345123122838679 0.9804498705230204 1.0059824051484738 0.952427482247564 1.1123547774868556 1.0228446912600684 1.088219124511752 1.0 18.261731677067374 -6.824616950847845 1.1574944757496382 1.055801963613024 0.948931387392962 0.5416337419568983 0.03916152406656727 0.3426952459716637 0.9674903957298889 0.020148202043123904 0.017100209275693737 1.4975559229865303e-07 6.824616950847845 -0.10687057622006202 GS(ph)PTGGAQLLKR ddPTM_A459_Selumetinib_30min_R1 1 GSPTGGAQLLKR 12 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 GS(0.88)PT(0.12)GGAQLLKR 99.732 0.025314 22023000.0 1507.8 1175.1 2595.2 2423.3 2063.1 1735.3 1931.2 1411.6 789.16 1212.1 True False 1542.9288063319257 1037.5187457108304 2242.786094413193 2000.1161459748084 1876.4929692698884 1717.8444575263354 1785.5280291819595 1374.159782476988 1339.146882034067 1367.6848418538193 1.1281318320678126 0.7585948999073007 1.6398413039170805 1.4624101143533654 1.372021471500999 1.2560236137426912 1.3055113097267186 1.0047342343974452 0.9791341112027894 1.0 10.417520110297733 -7.766459292639444 22.69466270631034 0.993950217973159 1.2790959934101922 0.26024094619791793 0.216261528294433 60.02070293637018 271326.87929058657 0.12245721310356798 0.06193680126750222 1.7121456522948306e-08 7.766459292639444 0.28514577543703323 GS(ph)PTSAYPER ddPTM_A459_Selumetinib_30min_R1 2 GSPTSAYPER 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 GS(0.997)PT(0.003)SAYPER;GS(0.997)PT(0.003)SAYPER 139.76 0.0014922000000000002 309080000.0 5358.4 6556.0 4731.2 5054.7 5911.1 5111.2 6341.4 5369.799999999999 3128.1000000000004 5080.7 True False 5483.240294368608 5788.420472198286 4088.7290266213354 4171.991533470418 5376.442048689468 5059.785968598286 5863.06309250957 5227.375460431379 5308.157232615393 5732.857335208897 0.9564585290990513 1.009692049486064 0.713209624371779 0.7277333604392576 0.9378293814621078 0.882594084022137 1.0227121921386395 0.9118272363637846 0.9259182502266073 1.0 12.485038662015794 -6.765217848729303 2.2917446485332857 0.9542527550663246 0.8552762409162838 0.185955503707523 0.09316139167183958 0.5770780022385862 6.223034817493592 0.0394215294385475 0.03629819630744199 1.7170468742275432e-07 6.765217848729303 -0.09897651415004072 GS(ph)PTSAYPER ddPTM_A459_Selumetinib_30min_R2 3 GSPTSAYPER 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 GS(1)PTSAYPER;GS(0.998)PT(0.002)SAYPER;GS(0.999)PT(0.001)SAYPER 143.0 0.0011383 412489000.0 88365.0 78603.0 92457.0 87020.0 92475.0 78671.0 78702.0 93786.0 75488.0 94351.0 True False 83454.02705312215 84631.59735151936 86508.41727957028 75167.72588212695 80857.46376301072 89507.21614576635 82361.7989450544 94058.90173289193 90587.70931094914 91626.84147666187 0.9108032723618286 0.9236550773506227 0.9441383756702418 0.8203679693714293 0.8824648155486817 0.9768667641846477 0.898882877743119 1.0265430982563066 0.9886590856023625 1.0 16.48348266774871 -7.757384692742308 24.999394668200473 1.0057008293625407 0.9084242398744217 0.5602789489436095 0.03933659823681379 78.53786976780432 484238.58849822875 0.020341689058266388 0.011196643335434764 1.7482973821015007e-08 7.757384692742308 -0.09727658948811901 GS(ph)PTSAYPERR ddPTM_A459_Selumetinib_30min_R1 1 GSPTSAYPERR 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 GS(0.931)PT(0.063)S(0.007)AYPERR 113.61 0.012569 3594400.0 1222.1 1104.2 2112.9 2533.4 2280.1 1451.1 1612.7 1589.4 797.97 1034.5 True False 1250.5725522073524 974.9197506713466 1825.9797853289288 2090.9892478077745 2073.8653575843505 1436.5032514933828 1491.052740607782 1547.2439489011938 1354.0968085771253 1167.288151883323 1.0713486213234127 0.8352005878740344 1.5642922292861974 1.791322257862496 1.776652452300094 1.2306329411257224 1.277364751969847 1.3255030014695544 1.1600364540601238 1.0 10.188945027350877 -8.395947193462758 1.1077113163841503 1.0025587123154667 1.386802545521086 0.15183341394762084 0.2796784813491741 1.0659209992055436 2.8139691496761396 0.3020812686188817 0.09845203653283409 4.018396681848441e-09 8.395947193462758 0.3842438332056193 GS(ph)PTTGFIEQK ddPTM_A459_Selumetinib_30min_R1 2 GSPTTGFIEQK 11 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 GS(0.993)PT(0.005)T(0.001)GFIEQK;GS(0.943)PT(0.055)T(0.002)GFIEQK 124.38 0.0035905 9235600.0 2445.6000000000004 2637.0 2577.3 2125.1 2336.8 2473.1 2910.6 2623.6000000000004 1256.0900000000001 2529.4 True False 2502.5777216907804 2328.2588140919597 2227.31681609553 1753.9911780675377 2125.436852595548 2448.2228593951377 2691.051098662497 2554.0136053461506 2131.4929888161737 2854.073128442417 0.8768442885191727 0.8157670491654797 0.7803993506329906 0.6145571956752074 0.7447030110806883 0.8577996250331651 0.9428809205498924 0.8948662106426051 0.7468249385675046 1.0 11.478806585379617 -6.863443403288041 4.785903654892973 0.8887297518186553 0.7618118634789693 0.3382170626582892 0.08610228686606099 0.2723777174587327 10.417124110368423 0.03251646392504678 0.02874487599637302 1.3694828460489295e-07 6.863443403288041 -0.12691788833968598 GS(ph)PTTGFIEQK ddPTM_A459_Selumetinib_30min_R2 2 GSPTTGFIEQK 11 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 GS(0.999)PT(0.001)TGFIEQK;GS(0.999)PT(0.001)TGFIEQK 175.48 7.5794e-05 9519600.0 42340.0 31212.0 38211.0 41461.0 45444.0 33352.0 36436.0 45083.0 35215.0 36116.0 True False 39986.91230044915 33605.86003760195 35752.54586099113 35813.94027578568 39734.91844548539 37945.935260688144 38130.34619656433 45214.184066107555 42258.98398931048 35073.23723936271 1.1400975629238985 0.958162481787854 1.0193682897587233 1.021118753064279 1.132912772616577 1.0819056992578207 1.0871635810614775 1.2891363223057055 1.204878343590229 1.0 15.09808297619757 -6.856512217841474 1.134925982356512 1.1711437649344885 1.0309408775808002 0.2109359066654174 0.08537368448061916 0.6023714594268025 1.6313577983906054 0.04681270007004161 0.03852683811742297 1.391514647341707e-07 6.856512217841474 -0.14020288735368824 GS(ph)PVFLPR ddPTM_A459_Selumetinib_30min_R1 4 GSPVFLPR 8 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 GS(1)PVFLPR;GS(1)PVFLPR;GS(1)PVFLPR;GS(1)PVFLPR 128.6 0.0042872 110177000.0 12583.0 17338.3 11157.5 12112.2 13042.6 12131.1 14630.9 13995.2 7422.1 12709.8 True False 12876.159417744146 15308.323775643008 9642.372783760482 9997.031644153045 11862.899132858056 12009.072148157518 13527.279433594835 13624.001833183589 12594.761611263935 14341.226633935887 0.8978422659659441 1.06743475759728 0.6723534206581446 0.6970834433713571 0.8271885966007034 0.8373811009819933 0.9432442411575175 0.949988601459298 0.8782206663871233 1.0 13.807880805473012 -7.242897820723344 6.067153034152857 0.938967477463739 0.8297091831504481 0.20550799253983076 0.10540741771419684 0.32041695594327047 47.31554511620393 0.04579457233534639 0.03393882447416858 5.716131079718118e-08 7.242897820723344 -0.10925829431329093 GS(ph)PVFLPR ddPTM_A459_Selumetinib_30min_R2 4 GSPVFLPR 8 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 GS(1)PVFLPR;GS(1)PVFLPR;GS(1)PVFLPR;GS(1)PVFLPR 131.62 0.0035228 111376000.0 119964.0 87358.0 102198.0 118052.0 126961.0 102312.0 127502.0 119881.0 118260.0 98327.0 True False 113296.88113394134 94058.0776997574 95622.69194476922 101973.11394894123 111011.02413425902 116404.54930413545 133431.0956404199 120229.83386263203 141915.30446048186 95488.04402577326 1.1865033187124587 0.985024655802669 1.0014101023889401 1.0679149938542838 1.162564646358197 1.2190484211061712 1.397359187757636 1.2591087720906786 1.4862101942540302 1.0 16.543032485425208 -6.6473568783506956 1.8251045783675233 1.3059865086217988 1.0500591057688868 0.3742546296438324 0.12850218084927753 0.3144569861660847 2.151746097256475 0.04820233569051039 0.04792460945136091 2.2523875682689449e-07 6.6473568783506956 -0.25592740285291193 GS(ph)PVPPVPER ddPTM_A459_Selumetinib_30min_R2 2 GSPVPPVPER 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 GS(1)PVPPVPER;GS(1)PVPPVPER 107.03 0.011542 16790700.0 137450.0 118971.0 154294.0 142781.0 174353.0 131980.0 138486.0 159635.0 127225.0 120697.0 True False 129811.07925594565 128095.6931479414 144366.89202260532 123333.98148903652 152449.21740440343 150159.04700484584 144925.87340480302 160099.51142100326 152673.55496351066 117212.16400153274 1.1074881208937337 1.0928532395858364 1.231671586753722 1.0522285168920158 1.3006262507226631 1.2810875755427762 1.2364405575082453 1.3658950227973754 1.3025401950732196 1.0 16.83876277145007 -6.271987056399821 24.96494160655809 1.2671596016405966 1.12694637148976 0.26022472881269165 0.10135259712596274 827.7912404255369 1959268.0188742136 0.02959036472183653 0.033904814818521416 5.345802916520109e-07 6.271987056399821 -0.14021323015083653 GS(ph)PVTTREPTPR ddPTM_A459_Selumetinib_30min_R1 1 GSPVTTREPTPR 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 GS(0.969)PVT(0.006)T(0.002)REPT(0.023)PR 116.9 0.02325 5695300.0 1973.9 1895.0 3565.0 3138.5 2763.7 1915.1 1686.9 1693.2 1171.5 1518.8 True False 2019.888029459203 1673.1325190384007 3080.8925811432764 2590.419891941542 2513.723822970866 1895.8358327716735 1559.6557748690188 1648.2908357112765 1987.9499370253297 1713.7527743648068 1.1786344329670675 0.9762974823825089 1.797746225260054 1.5115481828478248 1.4667948963073534 1.1062481480004343 0.9100821298142592 0.9618019940607866 1.15999808534936 1.0 10.742943286222596 -6.884603115078292 4.654285734426297 1.0053400920939202 1.392200346292706 0.42707009669811613 0.20959255168249208 0.22648321237277344 8.223563293290377 0.08195263575411467 0.07213781757650695 1.3043582364750246e-07 6.884603115078292 0.3868602541987858 GS(ph)RGPGNPLDHQITNER ddPTM_A459_Selumetinib_30min_R2 2 GSRGPGNPLDHQITNER 17 1 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5;Q96PC5-5;Q96PC5-8 G3V599 MIA2 Melanoma inhibitory activity protein 2 1 GS(1)RGPGNPLDHQITNER;GS(1)RGPGNPLDHQITNER 64.76100000000001 0.024743 9352100.0 25915.0 25588.0 35870.0 41832.0 44244.0 32759.0 30561.0 31629.0 37979.0 39884.0 True False 24474.74804596457 27550.517321612155 33562.16325230305 36134.409435774964 38685.6731736215 37271.254893406185 31982.14705547266 31721.035153537185 45575.86122192311 38732.44528892301 0.6318926642352746 0.7113033302209623 0.8665128938270624 0.9329235261608683 0.9987924306107551 0.9622747702961396 0.8257198020136144 0.8189783763177225 1.1766843245230694 1.0 15.241254965213159 -5.248007049488974 1.7221189817693137 0.9491774289754396 0.6215607219824782 0.5960889303566614 0.09456664323660027 0.3328994956370498 1.6733355075709047 0.027776805150710744 0.13149846936925372 5.649278048025075e-06 5.248007049488974 -0.3276167069929613 GS(ph)SDGRGSDSESDLPHR ddPTM_A459_Selumetinib_30min_R2 1 GSSDGRGSDSESDLPHR 17 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 GS(0.52)S(0.262)DGRGS(0.203)DS(0.012)ES(0.003)DLPHR 57.989 0.037965 16333000.0 24124.0 18419.0 21753.0 27284.0 26981.0 21507.0 15557.0 17613.0 20090.0 20984.0 True False 22783.284656023512 19831.67807358035 20353.435662875632 23567.872132474753 23591.405566799593 24469.39402889244 16280.431325610685 17664.25091401088 24108.561361500728 20378.137397020368 1.118025863313436 0.973184039699334 0.998787831602885 1.1565272955672965 1.1576821329239373 1.2007669568696835 0.7989165549541913 0.8668236242530044 1.1830601046504776 1.0 14.314734571834117 -7.2497241123520375 24.9979922108864 0.9511020311458207 1.0955047062974186 0.25916220129027345 0.1139967035440297 1079.6771867206887 2303814.965333285 0.045919938406805215 0.03525612911780706 5.626986686983526e-08 7.2497241123520375 0.14440267515159788 GS(ph)SGCSEAGGAGHEEGR ddPTM_A459_Selumetinib_30min_R2 2 GSSGCSEAGGAGHEEGR 17 0 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 GS(0.491)S(0.491)GCS(0.018)EAGGAGHEEGR;GS(0.958)S(0.042)GCSEAGGAGHEEGR 178.1 5.7513e-08 4305200.0 1628.6100000000001 2518.9900000000002 4271.150000000001 5882.0 5196.2 3737.46 4246.36 6480.900000000001 4791.1 4581.6 True False 1538.0983760423824 2712.1884331705414 3996.348859076505 5080.861452984041 4543.4069013826065 4252.261189716106 4443.824154002713 6499.758346029251 5749.45387451897 4449.317303573605 0.3456931189886169 0.6095740645406801 0.8981937197121713 1.1419418095677716 1.021146974106214 0.9557109326189823 0.998765394959249 1.4608439683114465 1.2922103509905036 1.0 12.119368272806865 -4.927715612802294 0.8470843358646047 1.1582146885234839 1.6071376560519783e-14 0.7634942520590938 0.1461889325568548 1.0439720214101909 0.6726579077629208 0.06075963801444992 1.0854753234509857 1.1810937930783086e-05 4.927715612802294 -1.1582146885234679 down GS(ph)SGNASEVSVACLTER ddPTM_A459_Selumetinib_30min_R2 1 GSSGNASEVSVACLTER 17 0 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1;C9J8U1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 GS(0.896)S(0.092)GNAS(0.01)EVS(0.001)VACLT(0.002)ER 84.895 0.012024 2368300.0 11475.0 9519.9 11633.0 11249.0 11583.0 9134.9 7002.5 10876.0 12539.0 6101.3 True False 10837.265438064567 10250.04571869687 10884.545445052736 9716.866794392632 10127.83998666616 10393.149556634085 7328.130125190515 10907.647359381275 15047.150368932675 5925.139615918815 1.8290312364874166 1.7299247584240072 1.837010796472998 1.6399388747375248 1.7092998044225207 1.7540767357972902 1.2367860675387878 1.840909761868931 2.539543596324068 1.0 12.532633433748188 -5.757508667324525 24.96205927825993 1.6959473706799977 1.7917825111617127 0.019743093633871944 0.3797096604631554 702.7301356945693 4462624.411795582 0.10359463750553348 0.17128394149880236 1.7477983808169856e-06 5.757508667324525 0.09583514048171504 GS(ph)SGSVDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R1 1 GSSGSVDETLFALPAASEPVIR 22 0 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 GS(0.847)S(0.148)GS(0.005)VDETLFALPAASEPVIR 227.57 2.3821e-30 6315400.0 885.1 773.72 869.1 771.5 892.58 876.01 874.92 1074.0 512.36 589.07 True False 905.7211078952031 683.1325027073306 751.0809936245785 636.7720078486216 811.8462965977988 867.1981347534406 808.9240799978672 1045.514031156337 869.4374987061873 664.6828725277038 1.3626364471388615 1.0277570416542632 1.1299839738134272 0.958008749987884 1.221403965940105 1.3046795255241004 1.2170075586898044 1.5729516651758773 1.308048596768904 1.0 9.376522368948349 -6.525686865504827 5.17306551027967 1.3090138205993378 1.1104805701182192 0.1651836421185986 0.1637004365003228 0.2564337372191339 21.028246231746866 0.05245469309854603 0.05510030279589083 2.9806647702365403e-07 6.525686865504827 -0.19853325048111858 GS(ph)SPLGPAGLGAEEPAAGPQLPSWLQPER ddPTM_A459_Selumetinib_30min_R1 2 GSSPLGPAGLGAEEPAAGPQLPSWLQPER 29 0 O43482;H0YKL4 O43482 OIP5 Protein Mis18-beta;Protein yippee-like 1 GS(0.5)S(0.5)PLGPAGLGAEEPAAGPQLPSWLQPER;GS(0.5)S(0.5)PLGPAGLGAEEPAAGPQLPSWLQPER 222.74 8.854e-47 5701000.0 1142.1399999999999 1049.6 1070.35 1155.8600000000001 906.25 890.54 1019.4000000000001 1018.5600000000001 590.22 813.99 True False 1168.7496397824284 926.7123440541985 925.0023490116986 954.0107491794012 824.2798475114331 881.5819761456252 942.5058372763515 991.5444800508369 1001.5602320367818 918.4735454340323 1.2724913478374884 1.0089700989877426 1.007108319679018 1.038691592068202 0.8974453881760011 0.95983382485886 1.0261654698295775 1.0795569289720526 1.0904617090125184 1.0 9.843094358121947 -4.761244112299443 24.6332075936087 1.010421903025707 1.2724916764485326 0.6880076654342866 0.05260951317195813 2.4254023033721106 305034.2012463547 0.014473136837709184 0.08145174838639524 1.732829718847925e-05 4.761244112299443 0.26206977342282567 GS(ph)SPLGPAGLGAEEPAAGPQLPSWLQPER ddPTM_A459_Selumetinib_30min_R2 2 GSSPLGPAGLGAEEPAAGPQLPSWLQPER 29 0 O43482;H0YKL4 O43482 OIP5 Protein Mis18-beta;Protein yippee-like 1 GS(0.5)S(0.5)PLGPAGLGAEEPAAGPQLPSWLQPER;GS(0.5)S(0.5)PLGPAGLGAEEPAAGPQLPSWLQPER 138.84 3.45e-14 6518700.0 10088.2 8278.1 11359.2 14223.4 14583.699999999999 10196.6 11829.0 9223.3 8605.8 10229.1 True False 9527.538230264312 8913.003651713205 10628.361438961836 12286.14838326643 12751.565226067803 11601.089094481078 12379.071938718822 9250.13827600049 10327.2004661425 9933.75930460642 0.9591070145867399 0.8972437702995405 1.069923390838886 1.2368075374615908 1.283659572882416 1.1678447945785737 1.2461618566677448 0.9311820422013926 1.039606472179534 1.0 13.27812407530098 -5.420801990942649 4.28898107118944 1.1403206438063291 0.9308602940428248 0.3435913494919992 0.10857391741430952 0.25218712059895426 7.8089547029932245 0.03140873253473385 0.06840764886205834 3.794879665113216e-06 5.420801990942649 -0.20946034976350436 GS(ph)SPLPTATTPKPLIPTEASIR ddPTM_A459_Selumetinib_30min_R1 1 GSSPLPTATTPKPLIPTEASIR 22 1 Q9BUK6-2;Q9BUK6;A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3 Q9BUK6-2 MSTO1 Protein misato homolog 1 1 GS(0.445)S(0.39)PLPT(0.129)AT(0.029)T(0.007)PKPLIPTEASIR 64.845 0.003993399999999999 12334000.0 1762.1 2026.9 2204.6 2001.6 2404.9 1721.3 1980.9 2100.8 1216.5 2032.5 True False 1803.1535015502627 1789.589605719754 1905.227429000973 1652.0581346854196 2187.3772196195814 1703.9852848153528 1831.4791181682597 2045.079959639882 2064.311650355368 2293.39117322654 0.7862389646391772 0.7803246243430881 0.8307468221047241 0.7203560186207406 0.9537741512025578 0.74299810024037 0.7985899394526653 0.8917274922457679 0.9001131924001943 1.0 11.16326673445326 -8.353837897054486 1.0441729717729773 0.9973861239912106 0.8007927612457849 0.517450818863719 0.06087966696189901 0.3931312146450281 0.9141192477800201 0.055527357672420424 0.0186078926395042 4.427536018855962e-09 8.353837897054486 -0.19659336274542571 GS(ph)SPQNTTTPK ddPTM_A459_Selumetinib_30min_R2 1 GSSPQNTTTPK 11 0 Q27J81-2;Q27J81 Q27J81-2 INF2 Inverted formin-2 1 GS(0.5)S(0.5)PQNTTTPK 145.81 0.00069526 4433200.0 33063.0 20794.0 28169.0 32483.0 34874.0 28605.0 38939.0 41924.0 37335.0 26588.0 True False 31225.490821675707 22388.832936751718 26356.637208088232 28058.759363699508 30492.816342484308 32545.07909966373 40749.7406561647 42045.99189910819 44803.043227059716 25820.335356079755 1.2093371519407177 0.8671007803730929 1.0207705223271701 1.0866922902723912 1.1809612819495914 1.2604437026415516 1.578203384820469 1.6284061116660855 1.735184404431456 1.0 14.656220118126825 -6.89273762595541 1.6817013418284295 1.538390196032022 1.0367946823016598 0.4705631163246706 0.20330794593734325 0.27596684550048783 1.6018970558342982 0.08824824203659398 0.07257703536778612 1.2801544612647473e-07 6.89273762595541 -0.5015955137303623 GS(ph)SPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK ddPTM_A459_Selumetinib_30min_R2 2 GSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK 38 1 Q27J81-2;Q27J81 Q27J81-2 INF2 Inverted formin-2 1 GS(0.378)S(0.354)PQNT(0.087)T(0.087)T(0.087)PKPS(0.007)VEGQQPAAAAACEPVDHAQSESILK;GS(0.382)S(0.339)PQNT(0.093)T(0.093)T(0.093)PKPS(0.001)VEGQQPAAAAACEPVDHAQSESILK 87.712 6.739099999999999e-10 102905000.0 124127.0 114533.0 146662.0 160473.0 160338.0 112636.0 123248.0 110614.0 91286.0 135027.0 True False 117228.51825975075 123317.31281836051 137225.92659351206 138616.30056863447 140194.9070000931 128150.58659219464 128979.27621127901 110935.8684268664 109545.75074394973 131128.41966772173 0.8939977966394074 0.9404316252025725 1.046500270050088 1.0571034175496583 1.0691420468220831 0.9772907117841205 0.9836103915391596 0.8460093449457937 0.8354081519592603 1.0 17.000620871440177 -7.674103048709225 5.749730480435443 0.8810868517391609 1.0010232958194027 0.3292617067639141 0.0656676869286553 0.21758425959058408 11.172606870495368 0.03355453017098429 0.018886416432813274 2.1178585534899725e-08 7.674103048709225 0.11993644408024184 GS(ph)SPTPPCSPVQPSK ddPTM_A459_Selumetinib_30min_R2 1 GSSPTPPCSPVQPSK 15 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GS(0.908)S(0.092)PTPPCSPVQPSK 183.28 2.0847e-05 89387000.0 84284.0 73203.0 78960.0 77893.0 76399.0 57385.0 73341.0 74487.0 57135.0 58334.0 True False 79599.83269558461 78817.43471525595 73879.79956514771 67283.8390270801 66801.0746042743 65289.262860835624 76751.50182243444 74703.74483801337 68563.5964852835 56649.745850066014 1.4051225032193477 1.3913113559919723 1.3041505916140244 1.1877165204793536 1.1791946036452774 1.1525076040700286 1.35484282710767 1.3186951453538838 1.2103072212671473 1.0 15.7897818631915 -14.522878745280336 0.09840488422193963 0.21633633271442523 1.451384303959122 0.543460294073479 0.08140344719448173 184.9263416690907 1.2378315207738473 30.67266171974944 1.6826843243576146 3.0000000000000132e-15 14.522878745280336 1.235047971244697 GS(ph)SQPNLSTSHSEQEYGK ddPTM_A459_Selumetinib_30min_R1 1 GSSQPNLSTSHSEQEYGK 18 0 I3L2B2;O95208-3;O95208-2;O95208;F6PQP6;E9PBC1 I3L2B2 EPN2 Epsin-2 1 GS(0.571)S(0.429)QPNLSTSHSEQEYGK 141.13 0.00020662 32428000.0 2612.7 2582.2 2584.1 3119.5 3132.8 2538.5 3442.0 2582.5 908.37 1992.7 True False 2673.5708265707794 2279.8748235677867 2233.1934134452576 2574.73788526737 2849.438793140764 2512.9649947735857 3182.3671688299037 2514.0037108577653 1541.437545280152 2248.4824555417104 1.1890556761879005 1.0139615801531852 0.9932002840143268 1.1451002781549644 1.2672719709766513 1.1176271305030732 1.4153400045379494 1.118089093673664 0.6855457295123901 1.0 11.134735911652463 -8.146747350579409 6.718497997818701 0.8463804583204627 1.1598487332927694 0.471910291674161 0.13366160700427085 0.2084747162658846 10.607309197962318 0.09474051485243569 0.035201395449626416 7.132678507368377e-09 8.146747350579409 0.31346827497230667 GS(ph)SQPNLSTSHSEQEYGK ddPTM_A459_Selumetinib_30min_R2 3 GSSQPNLSTSHSEQEYGK 18 0 I3L2B2;O95208-3;O95208-2;O95208;F6PQP6;E9PBC1 I3L2B2 EPN2 Epsin-2 1 GS(0.487)S(0.487)QPNLS(0.021)T(0.003)S(0.001)HSEQEYGK;GS(0.429)S(0.429)QPNLS(0.02)T(0.045)S(0.077)HSEQEYGK;GS(0.571)S(0.429)QPNLSTSHSEQEYGK 124.1 0.00057758 64911000.0 180165.0 125319.0 220226.0 247104.0 265960.0 170974.0 161943.0 162175.0 160987.0 219687.0 True False 170152.15055763873 134930.56433590382 206056.8989239389 213448.0089218235 232547.7270874328 194524.11655255768 169473.67038396696 162646.90240048352 193188.89835260893 213344.0654946251 0.7975480834826665 0.6324552033968023 0.9658431250300243 1.0004872103049007 1.0900126354500894 0.9117859271199575 0.794367867655717 0.7623690025002414 0.9055274066551247 1.0 17.70282245467093 -5.268209303338343 24.909170415049438 0.9232215097509556 0.7150016394988088 0.4263955981633134 0.09901984422008242 488.7296634154262 1798231.6601764474 0.029178783177010486 0.06302539919104494 5.3925067408647875e-06 5.268209303338343 -0.20821987025214683 GS(ph)SSQGPSQTSTPTDVTAIHL ddPTM_A459_Selumetinib_30min_R2 1 GSSSQGPSQTSTPTDVTAIHL 21 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 GS(0.539)S(0.418)S(0.042)QGPSQTSTPTDVTAIHL 85.054 0.0011305999999999998 2727900.0 14056.0 16044.0 18022.0 17993.0 21986.0 10847.0 14125.0 15565.0 12900.0 19907.0 True False 13274.82379062619 17274.523210408996 16862.484140869976 15542.322360343724 19223.922122666176 12341.075790737723 14781.840488156517 15610.29157307554 15480.360456115448 19332.233185402423 0.6866678910458144 0.8935606685860181 0.8722470900880024 0.8039589741799502 0.9943973848392211 0.6383678322303885 0.7646214664593503 0.8074748231809409 0.8007538657150336 1.0 14.238720681320688 -6.7579573663690775 24.99999111938067 0.7878594082583671 0.8512367817790796 0.03755263828255295 0.10976713988503492 261.91415036967544 1880479.4497328417 0.0355204168481259 0.034179968436114 1.7459935444391327e-07 6.7579573663690775 0.06337737352071249 GS(ph)SSSSPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R2 2 GSSSSSPEHSASSDSTK 17 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 GS(0.206)S(0.206)S(0.177)S(0.206)S(0.206)PEHS(0.001)ASSDSTK;GS(0.2)S(0.2)S(0.2)S(0.2)S(0.2)PEHSASSDSTK 73.983 0.015788 27531200.0 15981.3 13815.5 18537.1 26292.2 31264.0 21893.2 20953.4 21588.0 22634.8 23816.1 True False 15093.12332421275 14875.10442616589 17344.44316766844 22711.157003425193 27336.33681629378 24908.78957331787 21927.77461837443 21650.817505914216 27162.392469153634 23128.467311340868 0.6525777571439829 0.6431513262823082 0.749917533842103 0.9819568541962549 1.1819346456602255 1.0769753671097797 0.9480859376973204 0.9361112093795295 1.1744138555966812 1.0 14.497382043465937 -5.719983689825821 2.8611182844356624 1.0486392430990124 0.6549291296858928 0.8240211066644187 0.07783320299603759 0.10651629912437088 1.772187832614165 0.023815790992853178 0.043555705292719765 1.9055322799588196e-06 5.719983689825821 -0.39371011341311957 GS(ph)TESCNTTTEDEDLKVR ddPTM_A459_Selumetinib_30min_R2 1 GSTESCNTTTEDEDLKVR 18 1 Q8WU40;Q13555-10;Q5SWX3;Q13555-5;Q13555-4;Q13555-11 Q8WU40 CAMK2G 1 GS(0.821)T(0.144)ES(0.031)CNT(0.003)T(0.001)TEDEDLKVR 82.635 0.0051865 5398400.0 8833.6 6189.5 7951.8 7921.0 7494.3 5737.8 8600.3 6435.0 5377.7 5680.8 True False 8342.663875702585 6664.214747620695 7440.189845265221 6842.146135512848 6552.79903410794 6528.129867437533 9000.230991171145 6453.724784628404 6453.390265492408 5516.78054350902 1.5122341390792617 1.2079898221548313 1.3486470572078968 1.2402425801699213 1.1877940371976345 1.1833223772365669 1.631428134613894 1.169835329451664 1.1697746927934973 1.0 12.429610876137541 -13.793744715991657 0.20615962758804257 1.8352879577635819e-07 1.3393506623248783 0.2936505709981103 0.14731443444442985 143.34958105918224 1.8660368639162022 59.284727231506224 0.33809748949465984 1.607886111889065e-14 13.793744715991657 1.3393504787960826 GS(ph)YGDLGGPIITTQVTIPK ddPTM_A459_Selumetinib_30min_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;P61978-3;Q5T6W2;S4R359 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 GS(1)YGDLGGPIITTQVTIPK 225.86 9.5687e-21 57254000.0 4882.4 7333.1 4403.7 4043.5 4608.8 4597.9 5744.6 7220.3 3935.8 5777.2 True False 4996.150420503379 6474.537242934301 3805.7017277926057 3337.3786308955314 4191.93485374973 4551.64930055918 5311.2801969960055 7028.794189160239 6678.765140541434 6518.759894693411 0.7664265138175267 0.9932160943993181 0.5838076243444145 0.5119652640699837 0.6430571031097755 0.6982385260522396 0.8147684962778958 1.07824100023718 1.0245453504090978 1.0 12.67038182213369 -7.596877046138337 3.2820333188824016 1.0391298033741507 0.6983266329471767 0.601802722389033 0.12136445896032201 0.18867450441746736 4.085996503677709 0.07165424928248114 0.038615326944265234 2.5300141717490842e-08 7.596877046138337 -0.34080317042697406 GS(ph)YGDLGGPIITTQVTIPK ddPTM_A459_Selumetinib_30min_R2 2 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;P61978-3;Q5T6W2;S4R359 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 GS(1)YGDLGGPIITTQVTIPK;GS(1)YGDLGGPIITTQVTIPK 184.83 6.9058e-14 33332000.0 195016.0 113287.0 150636.0 204836.0 188712.0 218470.0 227749.0 259033.0 212829.0 152754.0 True False 184177.79143090203 121975.74862488177 140944.243760076 176936.9834381911 165004.31145331493 248562.25942679748 238339.77977608185 259786.74314477845 255400.7469391158 148343.59511744403 1.2415621401455719 0.8222515338684709 0.9501201831362525 1.192751081016404 1.1123116661874115 1.6755847074490142 1.6066738815881305 1.7512501496212531 1.7216836813002567 1.0 17.17858311280351 -6.708066771239687 5.388576203171387 1.601801358254039 1.044674224381425 0.5247155297511008 0.22935769974557607 0.13848291432239063 8.501481193856272 0.07444112851175613 0.07314337777467518 1.9585435312198816e-07 6.708066771239687 -0.5571271338726138 GS(ph)YQLQAQMNR ddPTM_A459_Selumetinib_30min_R2 2 GSYQLQAQMNR 11 0 Q9H1Z4-2;Q9H1Z4 Q9H1Z4-2 WDR13 WD repeat-containing protein 13 1 GS(0.998)Y(0.002)QLQAQMNR;GS(1)YQLQAQMNR 106.55 0.011056 8505700.0 56878.0 47605.0 41855.0 33189.0 52781.0 38800.0 38678.0 36659.0 24544.0 43976.0 True False 53716.948460674204 51256.150425799024 39162.09486827837 28668.6009457816 46150.17891187318 44144.34780866815 40476.60363900303 36765.67162077584 29453.485816658715 42706.29861663018 1.2578226210350243 1.2002011901316931 0.9170098120615008 0.6712967846531616 1.0806410390691628 1.033672999970032 0.9477900204453942 0.860895765067755 0.6896754523509394 1.0 15.382161243606895 -5.243298802548115 4.574102423014041 0.8987632185682032 1.2389889589658394 0.5193127231497405 0.1270628387866202 0.1571802766508877 8.799227043674794 0.034765110735916156 0.09133275783522055 5.710855841449251e-06 5.243298802548115 0.3402257403976362 GSADRNSPSPSS(ph)VASSDSGSTDEIQDEFER ddPTM_A459_Selumetinib_30min_R1 1 GSADRNSPSPSSVASSDSGSTDEIQDEFER 30 1 Q5TF58;H0Y4W3;J3KNZ4 Q5TF58 IFFO2 Intermediate filament family orphan 2 1 GSADRNS(0.007)PS(0.196)PS(0.285)S(0.416)VAS(0.067)S(0.027)DS(0.002)GSTDEIQDEFER 82.339 6.5576e-06 3007200.0 205.34 336.91 247.21 282.23 367.65 195.97 260.87 212.59 56.856 356.46 True False 210.12402247791323 297.4644205747902 213.64023982732937 232.94382861324246 334.3961224138795 193.9987197265235 241.19236587235812 206.95142261035917 96.48047940205903 402.21511321443177 0.522417024061178 0.7395654981671558 0.5311591554080465 0.5791523514658531 0.8313862692563814 0.4823257837730665 0.5996601270021694 0.5145292054205526 0.23987283478983218 1.0 8.651823481636463 GSASYS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 GSASYSPPR 9 0 A0A087WTY1;P0DPB5 A0A087WTY1 POLR1D 1 GS(0.001)AS(0.044)YS(0.955)PPR;GSAS(0.011)YS(0.989)PPR 108.98 0.021609 41494800.0 6375.3 7105.3 6523.5 6973.4 6779.9 5730.4 6621.1 5363.4 2966.4300000000003 4827.299999999999 True False 6523.83208582566 6273.408172835643 5637.6445310205245 5755.626596930111 6166.659242088564 5672.757378786904 6121.665096321805 5221.145209221506 5033.815050525011 5446.930976883875 1.1977078676987143 1.1517326361320235 1.0350130293455186 1.0566733122479988 1.1321346402697463 1.0414593838000537 1.1238741820488312 0.9585480762248362 0.9241562031698074 1.0 12.411227870228865 -1.5228787452803423 0.1914289578134147 0.9583340568734369 1.9823543319092618 0.5472190204366851 0.05627448256094811 46.04071834607746 0.5407903208826104 0.12152996757156419 13.956798420537861 0.029999999999999673 1.5228787452803423 1.024020275035825 GSDALS(ph)ETSSVSHIEDLEK ddPTM_A459_Selumetinib_30min_R1 2 GSDALSETSSVSHIEDLEK 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GS(0.067)DALS(0.52)ET(0.302)S(0.045)S(0.065)VS(0.001)HIEDLEK;GS(0.001)DALS(0.481)ET(0.37)S(0.055)S(0.091)VS(0.002)HIEDLEK 120.33 0.00028902 30497100.0 8988.8 9279.5 8850.6 9064.4 12063.4 8103.3 11167.2 9033.6 3180.3999999999996 7411.0 True False 9198.221550839906 8193.05182607749 7648.737132865828 7481.4726998613705 10972.267599966252 8021.788159207718 10324.849113235698 8793.999582731738 5396.906512774529 8362.274039253085 1.099966529159751 0.9797636130577335 0.9146719058670086 0.894669639471611 1.312115286877909 0.9592830994957708 1.2346939438686357 1.0516277679315582 0.6453874254109685 1.0 13.029679607234916 -8.205124703932833 16.030966629921004 0.8227070781726592 1.0545272386928024 0.2800789183069361 0.14951080775369416 7.119385464048247 2026.1914413338375 0.09936117976674219 0.037550389652016826 6.235557610891317e-09 8.205124703932833 0.2318201605201432 GSDALS(ph)ETSSVSHIEDLEK ddPTM_A459_Selumetinib_30min_R2 2 GSDALSETSSVSHIEDLEK 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GS(0.009)DALS(0.541)ET(0.205)S(0.186)S(0.055)VS(0.004)HIEDLEK;GS(0.015)DALS(0.703)ET(0.256)S(0.019)S(0.006)VS(0.001)HIEDLEK 104.3 0.00060922 28130800.0 102382.0 83222.0 113134.0 137185.0 140437.0 83304.0 96513.0 110975.0 82172.0 116799.0 True False 96692.01830761881 89604.85979909376 105855.08161098587 118500.16634267534 122794.04853729047 94778.36984157976 101001.04573688145 111297.91887709983 98608.69607751326 113426.70938975323 0.8524625181126324 0.7899802461093745 0.9332465182186501 1.044728944180941 1.0825849502108844 0.8355912849054392 0.8904520485543215 0.9812320173607565 0.8693604584673017 1.0 16.791400876329895 -5.3481905393539435 5.41840761228637 0.9563792354997378 0.8219220474267488 0.34387145689038245 0.07411129705149537 0.24434612948263054 11.556131275316181 0.020840433187921392 0.044823945246633606 4.485485536703043e-06 5.3481905393539435 -0.134457188072989 GSDALSET(ph)SSVSHIEDLEK ddPTM_A459_Selumetinib_30min_R1 1 GSDALSETSSVSHIEDLEK 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GSDALS(0.341)ET(0.594)S(0.02)S(0.044)VS(0.001)HIEDLEK 144.95 7.320699999999999e-05 22524000.0 7612.9 7981.6 7538.9 7472.5 11134.0 7118.5 9352.9 8175.2 2295.5 6188.8 True False 7790.265757875255 7047.110561454828 6515.158788213473 6167.568151197445 10126.931665867358 7046.894353080866 8647.40322293701 7958.367139207903 3895.295843313398 6983.192764016933 1.1155736381812364 1.009153090799276 0.9329770791642541 0.8832017616609058 1.4501864702990177 1.0091221295497061 1.2383165573626203 1.1396459195879367 0.557810155747829 1.0 12.769671082080349 -8.239464115321804 24.93052933372853 0.7789050329326483 1.0952495833658356 0.32764357100590424 0.18240767927274965 769.7190494856285 873235.053531509 0.1222459342579967 0.046121450730186406 5.761504224766162e-09 8.239464115321804 0.3163445504331872 GSDALSET(ph)SSVSHIEDLEK ddPTM_A459_Selumetinib_30min_R2 1 GSDALSETSSVSHIEDLEK 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GS(0.02)DALS(0.364)ET(0.418)S(0.091)S(0.104)VS(0.003)HIEDLEK 75.184 0.012797 21649000.0 70248.0 55210.0 94867.0 103470.0 104080.0 72165.0 82013.0 84673.0 65714.0 84391.0 True False 66343.89738502484 59444.4294718699 88763.36050337963 89377.20750429429 91004.53991299443 82105.073701354 85826.76700567642 84919.38441163032 78858.63620257133 81954.41255584966 0.8095219685677488 0.7253353128650659 1.0830821396332975 1.0905722427500313 1.1104287990714028 1.0018383530649027 1.0472501031861812 1.0361783064915524 0.9622256293867198 1.0 16.322534007959746 -5.262033757184714 24.99997331353024 1.0457498088929338 0.7674286227064805 0.8437442624146193 0.04713941947640281 17.724231686110667 745536.2687784125 0.012585719584561223 0.029020442360744213 5.469734456573273e-06 5.262033757184714 -0.2783211861864533 GSDALSETS(ph)SVSHIEDLEK ddPTM_A459_Selumetinib_30min_R1 1 GSDALSETSSVSHIEDLEK 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GSDALSETS(0.597)S(0.402)VSHIEDLEK 119.87 0.00029134 27237000.0 5969.2 8150.6 5538.5 5637.1 6491.0 6748.2 7727.8 6967.7 2746.0 5376.2 True False 6108.270745958701 7196.323962888862 4786.402120802815 4652.686306472413 5903.890196079127 6680.319234875363 7144.885824312526 6782.8939617206825 4659.7614400952225 6066.287638622642 1.0069207248051943 1.1862813621087702 0.7890166780633524 0.7669742326179593 0.9732295182461235 1.1012203233396525 1.1778020182924893 1.1181293017719065 0.7681405363022363 1.0 12.566598190961805 -6.550659825728953 10.897830490759118 1.0482057608556687 0.9352192614864882 0.08030486729232045 0.1493688770607554 1.30692593939675 503.2655294539158 0.05260410776468576 0.0527515263461174 2.814104199474351e-07 6.550659825728953 -0.11298649936918059 GSDALSETS(ph)SVSHIEDLEKVER ddPTM_A459_Selumetinib_30min_R1 1 GSDALSETSSVSHIEDLEKVER 22 1 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GSDALS(0.007)ET(0.006)S(0.491)S(0.491)VS(0.005)HIEDLEKVER 64.035 0.0033058 3690300.0 1404.9 1294.3 2640.3 2848.8 2146.4 2024.0 1081.2 1376.6 849.49 804.22 True False 1437.631436540471 1142.7627542962546 2281.7617621297604 2351.3105585990324 1952.2584989776974 2003.6403976449635 999.644213520886 1340.08809617301 1441.5224857052049 907.4494707661739 1.584255082904678 1.2593128224885093 2.514478035017457 2.591120094669055 2.151368822034107 2.207991146827446 1.101597659952207 1.4767633232972768 1.5885429791348102 1.0 9.825673501968943 -7.257279440992019 24.979919822737834 1.331456257209137 2.065539005408642 0.45698193226347306 0.40459635237642694 380.0107212806998 2281925.4897234077 0.17585821473109825 0.131235085153403 5.529941779900961e-08 7.257279440992019 0.7340827481995051 GSDALSETSS(ph)VSHIEDLEK ddPTM_A459_Selumetinib_30min_R1 2 GSDALSETSSVSHIEDLEK 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GSDALSETS(0.026)S(0.972)VS(0.001)HIEDLEK;GSDALSETS(0.01)S(0.989)VS(0.001)HIEDLEK 144.3 4.184e-05 18369600.0 8355.4 11267.0 7407.0 7863.6 8286.0 9166.8 10967.8 9002.0 4395.700000000001 7724.200000000001 True False 8550.064563221758 9947.854402113804 6401.170083738639 6490.369878053689 7536.532763012122 9074.590314788458 10140.490015773557 8763.237717383001 7459.181850774426 8715.676310079427 0.98099840552062 1.1413749258459036 0.734443301472299 0.7446777102710623 0.8647100345266769 1.0411802815914535 1.1634771250105256 1.0054569956032637 0.8558351165644023 1.0 13.089396902121559 -6.76326625746596 24.994442127067785 1.0229239318462304 0.8899504956120395 0.17570792465690377 0.12894397855852607 90.52718506108695 1238533.796782793 0.04888053797869273 0.04530411292651005 1.7247801387578115e-07 6.76326625746596 -0.1329734362341909 GSDDAPYS(ph)PTAR ddPTM_A459_Selumetinib_30min_R1 2 GSDDAPYSPTAR 12 0 O75151;E7ET14;A0A087WW48 O75151 PHF2 Lysine-specific demethylase PHF2 1 GSDDAPYS(0.944)PT(0.056)AR;GSDDAPYS(0.889)PT(0.111)AR 182.25 6.8592e-13 0.0 4126.7 7935.5 6396.5 7488.599999999999 6133.5 6342.799999999999 5753.3 4816.799999999999 3229.3 4477.6 True False 4222.844080839604 7006.407970886138 5527.89043345946 6180.85658843187 5578.726007957379 6278.997190801619 5319.323948991594 4689.042816828534 5479.886241259838 5052.343575517421 0.8358188665756235 1.3867639573915154 1.0941240141003943 1.22336426572076 1.1041857950814538 1.2427890338314083 1.052842877663329 0.9280926260736968 1.0846226428096057 1.0 12.30273703499916 -7.481300935620164 7.74261682936951 1.0018136670355533 1.1571634445702603 0.18605920854007973 0.13666639305252082 0.39663777175211234 66.62430851137465 0.05394367813324764 0.03565681527281914 3.301406974081709e-08 7.481300935620164 0.15534977753470702 GSDFDCELR ddPTM_A459_Selumetinib_30min_R1 3 GSDFDCELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;; 172.25 0.007034 96779000.0 14112.7 15485.6 15958.8 16879.1 16514.6 13092.6 13781.8 13300.2 8834.6 11301.8 False True 14441.498451466094 13672.53875293987 13791.682615413549 13931.482044948383 15020.857345889439 12960.90033112966 12742.227730209155 12947.435490861752 14991.670946345685 12752.49611885446 1.132444841925061 1.0721460822658189 1.0814888698552638 1.0924513848195414 1.1778758609995752 1.0163422290297408 0.9991947938231384 1.0152863698361825 1.1755871796879531 1.0 13.638492041208808 -6.793090388510662 24.999954728672265 1.0396070409703788 1.1064060671791467 0.2836516246856692 0.05531774605445169 285.28138692596195 225331.25258368388 0.019658505887195563 0.017338611077395684 1.6103104508337722e-07 6.793090388510662 0.06679902620876788 GSDFDCELR ddPTM_A459_Selumetinib_30min_R2 4 GSDFDCELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;;; 185.72 0.007034 141513000.0 564440.0 551460.0 639480.0 693190.0 699040.0 482859.0 503620.0 547180.0 508461.0 607380.0 False True 533070.6844323456 593755.2087766232 598336.5530131814 598776.3261805522 611220.3457031094 549368.4442924142 527039.3279040983 548772.2032094746 610167.4075873579 589843.3612372399 0.9037495705880126 1.0066320107955067 1.0143990630972373 1.0151446392896155 1.0362417988752637 0.9313802280321906 0.8935242176814443 0.9303693815564601 1.0344566840719998 1.0 19.1699723577766 -6.77669970787352 24.997171490070688 0.9495678188028923 0.9980376157886433 0.1115556815057146 0.04957195802640384 437.2248281395642 716191.557478433 0.017890293186445486 0.01583589807862546 1.6722464864313048e-07 6.77669970787352 0.048469796985750935 GSDIDNPTLTVMDISPPS(ph)RSPR ddPTM_A459_Selumetinib_30min_R1 2 GSDIDNPTLTVMDISPPSRSPR 22 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 GSDIDNPTLTVMDIS(0.236)PPS(0.735)RS(0.029)PR;GSDIDNPTLTVMDISPPS(0.675)RS(0.325)PR 175.85 2.8906e-16 44376000.0 8650.7 9887.7 10812.5 11760.2 10777.1 9456.0 9883.9 9425.1 5784.8 8004.5 True False 8852.244478667986 8730.043487332981 9344.221888811133 9706.5018362947 9802.313207851546 9360.881225361049 9138.349465426452 9175.115730960513 9816.383094924568 9031.955545432642 0.9801027511859783 0.9665729025590328 1.034573503136472 1.0746844121927912 1.0852924550551475 1.0364179914608571 1.0117797213968367 1.0158504085640974 1.0868502447278543 1.0 13.140822669960146 -5.316851594309409 4.931637241765867 1.0455677405553496 0.9731056342658726 0.4806424114064488 0.029083734937896278 0.16437035709266068 8.639659636890768 0.008018944773070061 0.017878388865299057 4.821125153927881e-06 5.316851594309409 -0.07246210628947702 GSDIDNPTLTVMDISPPS(ph)RSPR ddPTM_A459_Selumetinib_30min_R2 2 GSDIDNPTLTVMDISPPSRSPR 22 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 GSDIDNPTLTVMDIS(0.001)PPS(0.628)RS(0.371)PR;GSDIDNPTLTVMDIS(0.004)PPS(0.498)RS(0.498)PR 135.06 9.8531e-06 13532600.0 62858.0 58713.0 63558.0 67446.0 68734.0 48964.0 51678.0 52318.0 41685.0 55313.0 True False 59364.60400051089 63216.09830794956 59468.747476718105 58259.73844916039 60099.020430243596 55708.346549062546 54081.12939801431 52470.23671828884 50023.164776214915 53715.96996956668 1.1051574426403266 1.1768585458619714 1.107096223160649 1.0845887821101998 1.1188296602349972 1.037090954154317 1.0067979676929322 0.9768088847323502 0.9312531227595079 1.0 15.71306345045374 -7.034762222724646 1.0697271702140771 0.9616160975883258 1.1283607506066533 0.8489387817636946 0.028060033088288572 0.1804062995630797 0.422107428906431 0.017540248714168448 0.012182400839446961 9.230766755339674e-08 7.034762222724646 0.16674465301832753 GSDIDNPTLTVMDISPPSRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GSDIDNPTLTVMDISPPSRSPR 22 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 GSDIDNPTLTVMDISPPS(0.118)RS(0.882)PR 146.06 2.4646e-07 8414000.0 13973.0 15629.0 14571.0 17084.0 19266.0 12986.0 10835.0 12147.0 10428.0 10961.0 True False 13196.436598350867 16827.694044844317 13633.517723705274 14757.129728456197 16845.632839774706 14774.703624828982 11338.84896914519 12182.345758955891 12513.891382664486 10644.527449901836 1.2397390734778522 1.5808775095036747 1.2808006544086654 1.3863583703372655 1.5825627693721676 1.3880093498152644 1.0652280265621146 1.144470322077871 1.1756173716081582 1.0 13.377824284171448 -7.223496173492384 6.404171848876172 1.1082554335538866 1.4196594010333028 0.6517372736198572 0.11201301960776314 0.12805774203845408 15.791758435953666 0.042349946820170424 0.03217886546367404 5.977283111656043e-08 7.223496173492384 0.31140396747941623 GSDNSSYDEALSPTS(ph)PGPLSVR ddPTM_A459_Selumetinib_30min_R1 1 GSDNSSYDEALSPTSPGPLSVR 22 0 J3KQH6;P78364 J3KQH6 PHC1 Polyhomeotic-like protein 1 1 GSDNSSYDEALS(0.017)PT(0.26)S(0.719)PGPLS(0.004)VR 107.09 0.00016931 0.0 465.69 285.21 408.88 546.68 351.25 464.35 526.11 475.92 213.37 375.04 True False 476.53967092499977 251.81748060946828 353.3563418170723 451.2126004545489 319.47949951822426 459.6790605960665 486.4250991264092 463.2970555939702 362.0733060717835 423.1800371989577 1.126092038932723 0.5950599236113695 0.8350023884773708 1.066242640936325 0.7549493630013112 1.0862493978654972 1.14945190313341 1.0947989386752464 0.8556011017635861 1.0 8.725127762138392 -6.777182313239584 24.994359814331183 1.0501597130076221 0.8682413233788941 0.20606072094096028 0.15741113491289016 358.22966296265264 568741.8627939477 0.05480074257926657 0.04848868036264976 1.6703892514845868e-07 6.777182313239584 -0.18191838962872797 GSDS(ph)DSEGDNPEK ddPTM_A459_Selumetinib_30min_R1 3 GSDSDSEGDNPEK 13 0 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 GSDS(0.772)DS(0.228)EGDNPEK;GSDS(0.873)DS(0.127)EGDNPEK;GS(0.008)DS(0.943)DS(0.049)EGDNPEK 266.77 4.807699999999998e-38 33105000.0 6976.6 7880.110000000001 7478.0 6265.629999999999 7099.22 6945.98 8342.24 7987.5599999999995 4739.5 7222.8 True False 7139.141205899535 6957.5030578362475 6462.528673713718 5171.4553409417495 6457.096804469092 6876.109747645238 7712.978120424049 7775.703961548517 8042.5853406159185 8149.9167360298425 0.8759771954893986 0.8536900784615293 0.7929564047131455 0.6345408804091631 0.7922899108800721 0.8437030672039567 0.9463873521953742 0.9540838530500596 0.9868303690834749 1.0 12.992569604725992 -7.199681049740242 2.095809144426039 0.9767722506186763 0.78552641526511 0.6701089295601511 0.06073722568848806 0.22398184416452438 1.9254536367552604 0.03279594206901978 0.022125751854522167 6.314208961328583e-08 7.199681049740242 -0.19124583535356632 GSDS(ph)DSEGDNPEK ddPTM_A459_Selumetinib_30min_R2 1 GSDSDSEGDNPEK 13 0 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 GS(0.014)DS(0.957)DS(0.029)EGDNPEK 186.29 0.00013209 34220000.0 35193.0 28665.0 32285.0 35079.0 34895.0 32696.0 38286.0 40440.0 31493.0 33575.0 True False 33237.11394874131 30863.513327497756 30207.8182492502 30301.179685349725 30511.178134741953 37199.57721526325 40066.37486226975 40557.67370479759 37792.47998794135 32605.602511673584 1.0193681879315566 0.9465708635946194 0.9264609736450992 0.9293243292928318 0.9357648926689278 1.1408952557139502 1.2288187236510975 1.2438866507765645 1.159079332283792 1.0 14.9928322587713 -6.815255413942929 4.7544054767564115 1.1784100279934822 0.9480817009425772 0.6896367720369465 0.06746404936175063 0.10349681056063971 4.856312661705417 0.023297517188984467 0.020906189434264123 1.5301872749873712e-07 6.815255413942929 -0.230328327050905 GSDS(ph)DSEGDNPEKK ddPTM_A459_Selumetinib_30min_R1 1 GSDSDSEGDNPEKK 14 1 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 GSDS(0.974)DS(0.025)EGDNPEKK 199.15 0.00015308 4442300.0 1429.3 1960.5 1132.5 1468.5 1614.8 1807.4 1337.1 1464.1 1336.1 1585.4 True False 1462.5999090663352 1730.9637485882763 978.7127203772122 1212.0540421590422 1468.7416251160957 1789.2191969878988 1236.2414704946143 1425.2673119329536 2267.2641151169796 1788.9015331037424 0.8175966547072749 0.96761264751395 0.5471026226240338 0.6775409488615786 0.8210298878596356 1.0001775748291777 0.6910617759657999 0.7967276485364269 1.2674057644655705 1.0 10.804858263660345 -8.245568646286527 23.893560599124907 1.133702837188243 0.7887024573679515 0.49279564371390716 0.13953097221687766 329.31798307374055 495794.9006092482 0.0969780341369866 0.03634901778023282 5.681085869946617e-09 8.245568646286527 -0.3450003798202914 GSDS(ph)DSEGDNPEKK ddPTM_A459_Selumetinib_30min_R2 1 GSDSDSEGDNPEKK 14 1 Q9UN37;I3L4J1 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 1 GS(0.017)DS(0.983)DSEGDNPEKK 100.18 0.016467 6063700.0 14149.0 9892.8 10223.0 11190.0 12891.0 12656.0 16328.0 21763.0 12732.0 21052.0 True False 13362.655222934696 10651.545949634385 9565.263309960805 9665.90269617331 11271.517332997797 14399.249120270724 17087.284353318195 21826.32672694141 15278.75576180325 20444.17406033515 0.6536167801887535 0.5210064206164252 0.46787232791756017 0.4727949716944864 0.5513315089048414 0.7043204131296987 0.835802136241354 1.0676061875880742 0.7473403286781045 1.0 14.319402159061907 -7.092786963499401 1.8608124746778074 0.9319979730893815 0.5225854390009805 0.7936715879087012 0.09170430213639277 0.14795109784777835 1.0152416557146984 0.0428172322314774 0.030631610679420353 8.076311041545006e-08 7.092786963499401 -0.40941253408840095 GSEEDPLLS(ph)PVETWK ddPTM_A459_Selumetinib_30min_R1 2 GSEEDPLLSPVETWK 15 0 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GSEEDPLLS(1)PVETWK;GSEEDPLLS(0.999)PVET(0.001)WK 240.24 4.2259e-20 11023800.0 2960.7400000000002 3667.27 3391.73 3624.0499999999997 3050.52 2865.4900000000002 3235.7000000000003 3099.46 1850.6799999999998 2658.38 True False 3029.71948140283 3237.9043235324325 2931.151695439294 2991.177699343871 2774.6010046130477 2836.665772256751 2991.628543922986 3017.252252335028 3140.468791680782 2999.6089678140074 1.0100381462757013 1.079442140050703 0.9771779344877068 0.9971892108069405 0.9249875681746157 0.9456785209986878 0.9973395119241701 1.005881861506061 1.0469593955006167 1.0 11.550558726394938 -5.278970871825927 24.481035784906897 0.9841685210576744 1.044740144568793 0.298318973900073 0.035283146751753126 668.6917998024879 933763.5829067295 0.009835563556845044 0.020562794554335042 5.260525476041964e-06 5.278970871825927 0.060571623511118555 GSEEDPLLS(ph)PVETWK ddPTM_A459_Selumetinib_30min_R2 3 GSEEDPLLSPVETWK 15 0 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 GSEEDPLLS(1)PVETWK;GSEEDPLLS(0.999)PVET(0.001)WK;GSEEDPLLS(1)PVETWK 136.81 0.00040417 3987000.0 34130.4 31162.6 32748.5 36675.5 41171.2 32086.2 35025.1 36915.6 34975.0 40043.7 True False 32233.569002816457 33552.671216447954 30641.497163870852 31680.233631233605 35998.90578080202 36505.78280047652 36653.836550919004 37023.01828429345 41970.97728315019 38887.53433497254 0.82889207438971 0.862813027111189 0.7879516582339391 0.8146629549290497 0.9257183927042477 0.9387528272175886 0.9425600562686045 0.9520536315154783 1.079291294778868 1.0 15.24702014310847 -6.945311600338 0.7618349151194129 1.0199269284493782 0.8181551968859855 0.8012896428670792 0.038176487146037066 0.3031831325064995 0.3726889882036652 0.029798047590114014 0.02426185806339726 1.1341967530436903e-07 6.945311600338 -0.20177173156339268 GSEGDCS(ph)PEDKNSVTAK ddPTM_A459_Selumetinib_30min_R1 2 GSEGDCSPEDKNSVTAK 17 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GSEGDCS(1)PEDKNSVTAK;GS(0.048)EGDCS(0.894)PEDKNS(0.052)VT(0.007)AK 189.52 3.4094000000000003e-07 27216100.0 8592.2 10001.599999999999 10800.4 12032.7 9499.2 8218.1 8282.42 7990.98 5633.86 7461.33 True False 8792.381542489173 8830.608022382306 9333.765002350588 9931.414826753227 8639.999037219974 8135.433375437786 7657.670391185403 7779.0332520387965 9560.24893914598 8419.064385008794 1.0443418817588705 1.0488823482697576 1.1086463501776438 1.1796340273198722 1.0262421858424768 0.9663108634641102 0.9095631106968193 0.9239783539237859 1.1355476691886581 1.0 13.039444199413664 -6.50470775306298 8.107717703511799 0.9794001683563514 1.0943492611808463 0.3648287706574983 0.06706356946897787 0.2151844442396526 77.73670039133641 0.022086628531268998 0.023979824239512275 3.1281836871511723e-07 6.50470775306298 0.11494909282449495 GSEGDCS(ph)PEDKNSVTAK ddPTM_A459_Selumetinib_30min_R2 2 GSEGDCSPEDKNSVTAK 17 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GS(0.042)EGDCS(0.953)PEDKNS(0.004)VTAK;GS(0.047)EGDCS(0.944)PEDKNS(0.008)VT(0.001)AK 63.302 0.027122000000000004 110753000.0 275210.0 297790.0 287730.0 285220.0 252960.0 210430.0 238770.0 224400.0 158995.0 280870.0 True False 259914.9299529195 320629.5354542324 269217.76505673735 246372.54396805612 221180.90330890712 239414.82240665046 249873.2781137794 225052.96684858005 190798.44269147885 272760.5533121003 0.9529051279475795 1.1754981853529205 0.9870113613851297 0.9032557713217048 0.8108976925846961 0.8777472383724977 0.9160902303489148 0.8250935265960841 0.6995089296257656 1.0 18.057275491027823 -5.714285375667987 2.6829451367329384 0.8514574596735428 1.0668998906510552 0.4678311789971147 0.08892413291348399 0.213399201678883 3.1184828207849935 0.02505519673783854 0.046771016273347184 1.9306992342413874e-06 5.714285375667987 0.21544243097751237 GSEGDCSPEDKNS(ph)VTAK ddPTM_A459_Selumetinib_30min_R1 1 GSEGDCSPEDKNSVTAK 17 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 GS(0.004)EGDCS(0.021)PEDKNS(0.915)VT(0.06)AK 60.246 0.033359 33313000.0 3399.0 4081.9 4887.3 5333.3 3702.5 3775.9 4153.0 3517.7 2324.6 3430.8 True False 3478.1900866973156 3603.989250376172 4223.631504017263 4401.939273440121 3367.609528729469 3737.917874242894 3839.735866400517 3424.399168900045 3944.676417933486 3871.1765988219486 0.8984839616347587 0.9309803255870359 1.0910459381529045 1.1371062934146923 0.8699188587144999 0.9655766867831328 0.9918782489977338 0.8845887242504349 1.0189864288634893 1.0 11.91855640795576 -6.289310168045509 24.996927335588037 0.951744542802215 1.0139197811511806 0.12012523658957874 0.07822097403068899 1663.6308113753018 1492082.5761279208 0.025682649153177726 0.02913079674178319 5.136766586781912e-07 6.289310168045509 0.062175238348965656 GSEGSQS(ph)PGSSVDDAEDDPSR ddPTM_A459_Selumetinib_30min_R2 2 GSEGSQSPGSSVDDAEDDPSR 21 0 Q8IX07 Q8IX07 ZFPM1 Zinc finger protein ZFPM1 1 GSEGS(0.029)QS(0.826)PGS(0.072)S(0.072)VDDAEDDPSR;GSEGS(0.025)QS(0.974)PGSSVDDAEDDPSR 364.43 3.085099999999997e-218 10959200.0 31625.0 32019.0 37971.0 43860.0 43125.0 31031.0 32278.0 29530.0 28427.0 36245.0 True False 29867.409104905622 34474.75434268797 35527.987199698895 37886.19233727985 37707.25195760844 35305.23857862841 33778.99095764363 29615.92741104533 34113.194316743684 35198.51267418047 0.8485417944041304 0.9794378149386009 1.0093604672608825 1.0763577622718956 1.0712740139519654 1.0030321140394727 0.9596709744619945 0.841397126213512 0.9691657892626551 1.0 15.103226848101844 -7.43803860366831 4.4780207268071335 0.9242812642449277 1.003960906313648 0.12260855702389173 0.07025616120756178 0.38152699706654997 13.563850596893216 0.032648194572272346 0.021043301245679574 3.647215260333871e-08 7.43803860366831 0.07967964206872036 GSEGYLAATYPT(ph)VGQTSPR ddPTM_A459_Selumetinib_30min_R1 1 GSEGYLAATYPTVGQTSPR 19 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 GSEGYLAAT(0.001)Y(0.001)PT(0.672)VGQT(0.311)S(0.015)PR 92.781 0.0050872 6786400.0 1912.1 2619.3 2926.8 3135.3 2553.8 2358.1 2395.3 2492.8 1217.1 1933.1 True False 1956.6482097010714 2312.6311383204666 2529.356635761609 2587.778711870103 2322.809240910012 2334.3796549834915 2214.620592532906 2426.68284624443 2065.329806533101 2181.2322149885476 0.8970380119346186 1.0602406852553334 1.1595998896315995 1.1863838678376066 1.0649069021393522 1.0702114332176906 1.0153071173783914 1.1125284275416643 0.9468637920992492 1.0 11.090927652797017 -8.265140344320855 24.96772992785884 0.9734318881617545 1.0751766304023411 0.20563263726943315 0.07613944716659692 528.6615082147746 3566406.5269745607 0.06753934553460651 0.02004981351645331 5.430748059346998e-09 8.265140344320855 0.1017447422405866 GSEGYLAATYPTVGQT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 GSEGYLAATYPTVGQTSPR 19 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 GSEGYLAATYPTVGQT(0.906)S(0.094)PR 235.72 2.0907e-24 5612000.0 1247.7 1843.5 1664.2 1648.9 1689.4 1520.2 1143.9 1548.0 864.84 1009.6 True False 1276.7689823984238 1627.6621629801011 1438.2107807962518 1360.950568686445 1536.5940682877945 1504.9081682311623 1057.6147020408266 1506.942011387346 1467.5703145855618 1139.1919943367839 1.1207671654519786 1.4287865180510642 1.2624832231493612 1.194663037883061 1.3488455641600348 1.3210312008093874 0.9283902163098943 1.3228165391599853 1.288255466928517 1.0 10.153795197586055 GSEGYLAATYPTVGQT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 GSEGYLAATYPTVGQTSPR 19 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 GSEGYLAATYPTVGQT(0.813)S(0.187)PR 232.51 1.6898e-23 18689000.0 82890.0 59060.0 82795.0 85289.0 92122.0 69568.0 67917.0 77141.0 67128.0 79318.0 True False 78283.30563496053 63589.712092168724 77468.05984038008 73672.49106826872 80548.81077887083 79150.3605245729 71075.27507498239 77365.46753861997 80555.47571303237 77027.88324708644 1.0162982849190727 0.8255414716277302 1.0057145097948708 0.9564392524190953 1.045709779152182 1.0275546618706641 0.9227213845016413 1.004382624541955 1.0457963054058006 1.0 16.233093159649805 GSEGYLAATYPTVGQTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 GSEGYLAATYPTVGQTSPR 19 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 GSEGYLAATYPTVGQT(0.424)S(0.576)PR;GSEGYLAATYPTVGQT(0.012)S(0.988)PR;GSEGYLAATYPTVGQT(0.032)S(0.968)PR 282.86 7.511899999999996e-72 287769500.0 10290.1 12685.6 12758.599999999999 14093.7 12240.1 11390.900000000001 11421.099999999999 11045.3 5463.52 8611.4 True False 10529.839308950892 11200.364054624562 11026.052197973242 11632.49986651474 11132.985116165179 11276.317888109697 10559.597231819635 10752.342763809209 9271.19440028735 9716.75707213925 1.083678353876211 1.1526854043453698 1.1347461005882427 1.1971586590209689 1.145751101268824 1.1605021926957668 1.0867408903426279 1.1065772956945978 0.9541449201061682 1.0 13.246259185264721 -8.052976141204248 1.8068252306370716 0.9759589192512725 1.1444066217088744 0.7557895487991234 0.035252269030615756 0.16762036117198748 0.9788313389718657 0.03034378254844309 0.009779869964296297 8.851642366808555e-09 8.052976141204248 0.16844770245760188 GSEGYLAATYPTVGQTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 GSEGYLAATYPTVGQTSPR 19 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 GSEGYLAATYPTVGQT(0.015)S(0.985)PR;GSEGYLAATYPTVGQT(0.086)S(0.914)PR;GSEGYLAATYPTVGQT(0.018)S(0.982)PR 173.09 1.6938e-09 157925000.0 493235.0 360858.0 510467.0 571766.0 568422.0 438268.0 451405.0 430597.0 381066.0 477769.0 True False 465822.9732761463 388534.6482586488 477624.1089744461 493890.48444863496 497011.7466028446 498635.4387992101 472396.2269420378 431849.9659808293 457289.8478736502 463974.56757706066 1.0039838513320638 0.8374050549529697 1.0294187275579891 1.064477492867334 1.0712047196860566 1.0747042481297053 1.0181511228276072 0.9307621498221541 0.9855924868073718 1.0 18.823686201694755 -5.295949964795788 24.75807750864643 1.0243654651723348 0.9206944344269298 0.3436225457580724 0.05579774953978975 534.3700626964951 383358.92459704605 0.015415946212654456 0.032093345100240485 5.0588294157907114e-06 5.295949964795788 -0.10367103074540507 GSEMDNNCS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 GSEMDNNCSPTR 12 0 O95243-3;O95243-5;O95243-2;O95243 O95243-3 MBD4 Methyl-CpG-binding domain protein 4 1 GSEMDNNCS(0.661)PT(0.339)R 100.11 0.013745 4541000.0 21923.0 18112.0 20268.0 23180.0 22593.0 19020.0 22546.0 22280.0 21462.0 18584.0 True False 20704.607424722402 19501.13216074094 18963.978946129868 20022.844012269634 19754.665356017314 21639.83235363062 23594.43367405145 22344.83111134743 25754.999698383686 18047.431632969237 1.1472329052572228 1.080548886807587 1.0507854708526099 1.109456703838772 1.0945970461486212 1.199053294325756 1.307356866832447 1.2381169556851324 1.4270728501519399 1.0 14.13950591837794 -6.900271875057319 3.2176692596122645 1.2627807819499433 1.0930647269469602 0.31170729638455774 0.10201829250906164 0.25773784117155674 5.315420977333868 0.03628070508188973 0.031355094611721535 1.2581375516628136e-07 6.900271875057319 -0.16971605500298304 GSES(ph)PNSFLDQESR ddPTM_A459_Selumetinib_30min_R2 3 GSESPNSFLDQESR 14 0 A0A5H1ZRR2;Q6P9H4;Q5T4Y8;G9CGD6-3;G9CGD6;G9CGD6-2 A0A5H1ZRR2 CNKSR3 Connector enhancer of kinase suppressor of ras 3 1 GSES(0.994)PNS(0.005)FLDQESR;GS(0.002)ES(0.908)PNS(0.074)FLDQES(0.016)R;GS(0.02)ES(0.973)PNS(0.007)FLDQESR 162.64 0.00027409 15194000.0 36953.5 37291.2 43173.8 39955.9 46667.0 37262.1 34196.1 37728.1 35147.9 39904.6 True False 34899.77240658117 40151.31512989305 40396.04471207924 34513.83749222797 40804.27425172666 42394.616043334354 35786.28640828664 37837.88252477682 42178.46211437986 38752.45051339779 0.9005823359355135 1.0360974492699924 1.042412652023469 0.8906233550390726 1.052946941706809 1.0939854249649934 0.9234586699469325 0.9763997379132249 1.0884076117921266 1.0 15.241999921723304 -4.752580229052593 24.852428784519123 1.0091506970893385 0.9005821120355882 0.21720609810340474 0.06306933073144601 532.1786885498399 1492792.1495716148 0.01574831193055994 0.18465513412179232 1.7677456244587493e-05 4.752580229052593 -0.10856858505375022 GSES(ph)PNSFLDQEYR ddPTM_A459_Selumetinib_30min_R1 4 GSESPNSFLDQEYR 14 0 A0A2R8YE27;A0A2R8YE71;A0A2R8Y7K8;A0A2R8Y5S6;A0A2R8Y622;A0A2R8YGJ7;A0A2U3TZH5;A0A2R8Y700;A0A2R8Y7A1;A0A2R8YED7;Q8WXI2-4;Q8WXI2-2;Q8WXI2-5;Q8WXI2;A0A2R8Y604 A0A2R8YE27 CNKSR2 Connector enhancer of kinase suppressor of ras 2 1 GSES(0.975)PNS(0.025)FLDQEYR;GSES(0.987)PNS(0.013)FLDQEYR;GS(0.003)ES(0.864)PNS(0.133)FLDQEYR;GS(0.001)ES(0.981)PNS(0.018)FLDQEYR 254.68 5.056499999999999e-28 67727000.0 6026.9 7273.500000000001 6174.1 7163.599999999999 7213.5 6099.1 6380.3 6054.1 3524.6699999999996 5755.200000000001 True False 6167.315043694047 6421.915238641586 5335.6911319037035 5912.611737426297 6561.04019864686 6037.748591539724 5899.028834191004 5893.525601511714 5981.107558288574 6493.935980395268 0.9497037023944697 0.9889095393038817 0.821642090099406 0.9104819873919379 1.0103333661517722 0.9297517884018657 0.9083903586360803 0.9075429168541004 0.921029646172231 1.0 12.664877446738886 GSES(ph)PNSFLDQEYR ddPTM_A459_Selumetinib_30min_R2 3 GSESPNSFLDQEYR 14 0 A0A2R8YE27;A0A2R8YE71;A0A2R8Y7K8;A0A2R8Y5S6;A0A2R8Y622;A0A2R8YGJ7;A0A2U3TZH5;A0A2R8Y700;A0A2R8Y7A1;A0A2R8YED7;Q8WXI2-4;Q8WXI2-2;Q8WXI2-5;Q8WXI2;A0A2R8Y604 A0A2R8YE27 CNKSR2 Connector enhancer of kinase suppressor of ras 2 1 GS(0.166)ES(0.833)PNS(0.001)FLDQEYR;GS(0.024)ES(0.805)PNS(0.17)FLDQEYR;GS(0.03)ES(0.951)PNS(0.019)FLDQEYR 210.67 4.2028e-06 32602600.0 73915.0 67892.0 77442.0 89082.0 83566.0 64806.0 61759.0 69174.0 68529.0 66028.0 True False 69807.10020518894 73099.09809281272 72459.46603247424 76948.8779249785 73067.69199048135 73732.43824970479 64630.91587313687 69375.28488762781 82236.71486024297 64121.60007865332 1.0886674711729218 1.1400073922538951 1.1300320943893083 1.2000461284589108 1.1395176025060902 1.149884565563906 1.007942967640527 1.081933152050638 1.282511895513667 1.0 15.968522806238665 GSESPNS(ph)FLDQESR ddPTM_A459_Selumetinib_30min_R1 1 GSESPNSFLDQESR 14 0 A0A5H1ZRR2;Q6P9H4;Q5T4Y8;G9CGD6-3;G9CGD6;G9CGD6-2 A0A5H1ZRR2 CNKSR3 Connector enhancer of kinase suppressor of ras 3 1 GSES(0.085)PNS(0.851)FLDQES(0.064)R 204.67 2.1015e-05 19005000.0 3499.7 3909.3 3578.2 4179.6 3596.2 3084.1 3483.3 3347.3 1805.7 2768.6 True False 3581.2362007692254 3451.597338615737 3092.3000936456865 3449.7113208089436 3270.9243449606765 3053.07675413875 3220.5518765790803 3258.5187304372494 3064.141016890003 3123.9767784477253 1.146370941511514 1.10487291788731 0.989860140760144 1.1042691945114498 1.047038623182714 0.9773045610331953 1.030914153651085 1.043067526275396 0.9808462847833798 1.0 11.6091680141526 -1.5228787452805432 0.4598263453645774 1.0114028146473837 4.323905736842277 0.5686900137997677 0.03672999223177473 70.03951569002514 0.824875261128694 0.022605833828898476 219.16667331304507 0.02999999999998579 1.5228787452805432 3.312502922194893 GSESPNS(ph)FLDQEYRK ddPTM_A459_Selumetinib_30min_R1 1 GSESPNSFLDQEYRK 15 1 A0A2R8YE27;A0A2R8YE71;A0A2R8Y7K8;A0A2R8Y5S6;A0A2R8Y622;A0A2R8YGJ7;A0A2U3TZH5;A0A2R8Y700;A0A2R8Y7A1;A0A2R8YED7;Q8WXI2-4;Q8WXI2-2;Q8WXI2-5;Q8WXI2;A0A2R8Y604 A0A2R8YE27 CNKSR2 Connector enhancer of kinase suppressor of ras 2 1 GS(0.108)ES(0.109)PNS(0.761)FLDQEY(0.021)RK 71.872 0.024446 6566600.0 1904.8 1791.1 2354.6 2279.0 2123.2 1670.6 1962.4 2259.1 1185.5 1872.9 True False 1949.1781339043991 1581.3971793402006 2034.8582528919942 1881.0154321283328 1931.156934881406 1653.7952807834365 1814.3745880626957 2199.181329409013 2011.706914505787 2113.304958590892 0.9223364219066947 0.7483052424173762 0.9628796093152573 0.8900823444726855 0.913808926170817 0.7825634790949211 0.8585483986525462 1.0406360522976208 0.9519245702461946 1.0 11.045285253781154 -7.751793229066469 24.978083754389615 0.9972102349535431 0.8666620160330322 0.4653884109574564 0.06341917316805562 165.58421676655158 428772.4356549664 0.029861697124470492 0.016957801701616843 1.7709519214224946e-08 7.751793229066469 -0.13054821892051094 GSET(ph)PGATPGSK ddPTM_A459_Selumetinib_30min_R1 5 GSETPGATPGSK 12 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GS(0.069)ET(0.928)PGAT(0.003)PGSK;GSET(1)PGATPGSK;GSET(1)PGATPGSK;GSET(0.999)PGAT(0.001)PGSK;GSET(1)PGATPGSK 241.35 4.6955e-13 506741700.0 48110.3 54403.7 52117.600000000006 53956.7 50947.3 44068.7 48628.0 47082.7 24930.3 40231.2 True False 49231.176383652215 48034.08951240602 45040.31618148467 44534.17523770021 46339.12571047636 43625.40888917817 44959.95080937259 45833.91384983658 42304.89826293005 45395.26640507334 1.0845002195680513 1.0581299178594041 0.9921808978843442 0.9810312564378543 1.0207920204054037 0.9610122892527542 0.9904105509192012 1.009662845479286 0.9319231191515178 1.0 15.470254247771187 -5.179837364198722 2.687940541287498 0.9857389037597527 1.0824134222567592 0.6828596569339549 0.02364205947387026 0.15893007495094955 2.1556896798485248 0.006094740426866802 0.02242876565143198 6.609409126539219e-06 5.179837364198722 0.09667451849700648 GSET(ph)PGATPGSK ddPTM_A459_Selumetinib_30min_R2 3 GSETPGATPGSK 12 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 GS(0.082)ET(0.918)PGATPGSK;GSET(1)PGATPGSK;GS(0.071)ET(0.929)PGATPGSK 209.67 1.5964e-05 283627000.0 291102.0 258383.0 283829.0 307385.0 320893.0 225511.0 266096.0 296545.0 243525.0 245197.0 True False 274923.7162136358 278200.1452677082 265567.7511496501 265518.6327312986 280579.55252018175 256573.093264963 278469.9912592208 297407.8968543325 292236.8046570171 238117.52551168538 1.1545715319477574 1.1683312459672601 1.115280156632644 1.1150738785846679 1.1783238210511833 1.0775061294359534 1.1694644930515843 1.2489962518098545 1.2272796974058757 1.0 17.861314281682276 -7.508871203193843 24.825608099364295 1.1847288568194096 1.1354683323937835 0.0 0.0689421728868202 1409.8425388683747 2498684.3551647174 0.02834525467930385 0.018228103085788157 3.098338023471997e-08 7.508871203193843 -0.04926052442562612 GSETDS(ph)AQDQPVK ddPTM_A459_Selumetinib_30min_R1 2 GSETDSAQDQPVK 13 0 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 GSET(0.013)DS(0.987)AQDQPVK;GSET(0.018)DS(0.982)AQDQPVK 157.07 0.00036504 13235900.0 7055.1 7594.0 7947.4 8887.4 8524.1 7175.4 7112.2 7421.0 4000.8999999999996 6743.5 True False 7219.470103165121 6704.89094964518 6868.186731943355 7335.382427159876 7753.096660052082 7103.221990741933 6575.721027934928 7224.170973194767 6789.235085825561 7609.093912252481 0.9487949795888351 0.8811681163309977 0.9026287244114459 0.9640283733846597 1.018925084834046 0.9335174559094387 0.86419238660551 0.9494127758841437 0.8922527654565088 1.0 12.893508953091594 -5.744589509039818 24.806377593351403 0.9430430941368118 0.9078943432254625 0.10773909188188946 0.04559148125461467 552.1899359418096 812926.7760576252 0.012992677503819192 0.022424859104637554 1.8005719943821669e-06 5.744589509039818 -0.03514875091134928 GSETDS(ph)AQDQPVK ddPTM_A459_Selumetinib_30min_R2 2 GSETDSAQDQPVK 13 0 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 GSET(0.031)DS(0.969)AQDQPVK;GSET(0.014)DS(0.986)AQDQPVK 147.83 0.00056279 12084000.0 136365.0 116515.0 126583.0 133990.0 149322.0 123376.0 110969.0 118023.0 99812.0 127578.0 True False 128786.3792123465 125451.3258452256 118438.78759314952 115740.33085435753 130562.83540438284 140369.9241041816 116129.27838090192 118366.42739024048 119777.18898029397 123894.49165254772 1.0394843022845413 1.012565806372118 0.9559649183218065 0.934184638159234 1.0538227621171081 1.1329795395410955 0.9373239829465322 0.9553808713480963 0.9667676696733185 1.0 16.91875252113882 GSFS(ph)DTGLGDGK ddPTM_A459_Selumetinib_30min_R1 2 GSFSDTGLGDGK 12 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 GSFS(0.942)DT(0.058)GLGDGK;GS(0.001)FS(0.5)DT(0.5)GLGDGK 166.62 0.00046273 370030000.0 7865.4 9323.900000000001 9667.7 11206.8 8932.8 8041.0 9277.2 8504.1 5231.2 7191.9 True False 8048.648516595787 8232.253453436486 8354.87944087485 9249.742757690126 8124.829817213932 7960.1148406438515 8577.413334883428 8278.54364279014 8876.964328268807 8115.050420038357 0.9918174379695037 1.0144426747009139 1.029553608224576 1.1398256669915314 1.001205093828059 0.9809076257848103 1.0569759756148114 1.0201469139794959 1.0938889925254276 1.0 12.986384343146156 GSFS(ph)DTGLGDGK ddPTM_A459_Selumetinib_30min_R2 1 GSFSDTGLGDGK 12 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 GS(0.005)FS(0.991)DT(0.004)GLGDGK 103.14 0.010973 80799000.0 20013.0 20859.0 21563.0 23777.0 23199.0 16573.0 18955.0 15949.0 12520.0 20299.0 True False 18900.757578386605 22458.818227743777 20175.660056019275 20538.531582387193 20284.53421830859 18855.780315284985 19836.44505861996 15995.408949500923 15024.349838028314 19712.915126864096 0.9588007383357162 1.1392946240172088 1.0234742008565016 1.0418820073139754 1.0289971872635675 0.9565191243373723 1.0062664466904503 0.8114177353557881 0.7621576890753026 1.0 14.266853516057289 -7.7132111742639715 5.955555087397184 0.8400651418178454 1.0263735755493826 0.5025603430553881 0.07429194553764305 0.13411147912262478 10.816845293448788 0.03544568058674224 0.01971443444160318 1.9354806140158212e-08 7.7132111742639715 0.18630843373153716 GSFSDT(ph)GLGDGK ddPTM_A459_Selumetinib_30min_R2 1 GSFSDTGLGDGK 12 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 GSFS(0.145)DT(0.855)GLGDGK 169.58 0.00079922 89302000.0 297710.0 303180.0 287820.0 348120.0 304790.0 231160.0 252480.0 231660.0 222810.0 268130.0 True False 281164.4700275557 326432.93112264975 269301.9745547223 300705.45545950445 266499.5553428282 263000.1917384467 264220.82027962897 232334.09224662252 267378.22583155637 260388.39021459574 1.0797888100765078 1.2536385775634016 1.034231880817653 1.154834342697391 1.023469422439288 1.0100304069689838 1.014718129567431 0.8922597972019696 1.0268438835203062 1.0 17.99030559977131 -6.394819478444071 1.0452658913295976 0.9726798832455709 1.1490832387262633 0.5168892360642374 0.06409997923382273 0.37798761865178554 0.8762600892613559 0.02850797777541272 0.0377986857038203 4.0288446499759804e-07 6.394819478444071 0.17640335548069241 GSFWALHPSCGDMFENGS(ph)FLRRR ddPTM_A459_Selumetinib_30min_R2 1 GSFWALHPSCGDMFENGSFLRRR 23 2 Q99853 Q99853 FOXB1 Forkhead box protein B1 1 GS(0.104)FWALHPS(0.026)CGDMFENGS(0.87)FLRRR 49.973 0.018568 6500900.0 29997.0 28962.0 32397.0 33424.0 37303.0 25275.0 29173.0 26715.0 23010.0 28601.0 True False 28329.886827505252 31183.292272492214 30312.612291186557 28871.593540383965 32616.66364694881 28756.401826394023 30529.60230520283 26792.736227093672 27612.64295311753 27775.21481567764 1.019970034993736 1.1227021097561736 1.0913547381126534 1.039473276155815 1.1743082407606955 1.0353259917962023 1.0991670994375347 0.9646275071100653 0.9941468728994908 1.0 14.76151044912293 -7.759449171250133 24.999946887782084 0.9845403784399721 1.085002654190027 0.5072369599395868 0.04374410618016351 39.12398861259574 491477.468995607 0.020625983102157748 0.011139347819118836 1.740006332150564e-08 7.759449171250133 0.10046227575005495 GSGDISSDSIDHS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 GSGDISSDSIDHSPAK 16 0 Q5JSS2;H0Y306;Q9H5I1-3;Q9H5I1-2;Q9H5I1 Q5JSS2 SUV39H2 Histone-lysine N-methyltransferase SUV39H2 1 GSGDISSDS(0.001)IDHS(0.999)PAK;GSGDISSDSIDHS(1)PAK 150.61 0.00014884 21931300.0 7106.5 7185.200000000001 8299.3 8430.8 9167.9 7337.3 7737.2 7433.6 2769.0 5055.4 True False 7272.06762315813 6343.9534436911445 7172.30064479169 6958.5190457163435 8338.665063724207 7263.493423735374 7153.57677474454 7236.4367802642 4698.790760241687 5704.3098337660285 1.2748374185623532 1.112133391867815 1.257347664100581 1.2198704573384431 1.4618183981459782 1.2733343095671155 1.2540652564837445 1.268591116392191 0.8237264274159368 1.0 12.477836629609751 -8.25288972401074 24.76208047944163 0.9118632095269992 1.2648187970989597 0.7139975606149824 0.08946329029489201 260.74187130556214 755184.2936783469 0.06444991819486083 0.023480552867682476 5.586120194096278e-09 8.25288972401074 0.35295558757196055 GSGDISSDSIDHS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 GSGDISSDSIDHSPAK 16 0 Q5JSS2;H0Y306;Q9H5I1-3;Q9H5I1-2;Q9H5I1 Q5JSS2 SUV39H2 Histone-lysine N-methyltransferase SUV39H2 1 GSGDISSDSIDHS(1)PAK;GSGDISSDSIDHS(1)PAK 101.28 0.0036795 39772000.0 228780.0 158576.0 232941.0 234930.0 248460.0 197824.0 181970.0 219856.0 192315.0 227430.0 True False 216065.32347890284 170738.26929779482 217953.82966698427 202932.12872314503 217246.23353941776 225072.4603325252 190431.9655667143 220495.7445608801 230783.37373006553 220863.5049658953 0.9782753538764434 0.7730488082409062 0.9868259117803988 0.9188124074843459 0.983622140620126 1.0190568168665068 0.8622156276842564 0.9983348973608294 1.0449140240063746 1.0 17.752795524843584 -5.314808152953554 24.99699332367008 0.9722638642927706 0.8756614166594389 0.2632676873830402 0.06729364002707522 369.56092149104563 173095.07153963333 0.0169275435419934 0.035237527793296385 4.843862951418681e-06 5.314808152953554 -0.0966024476333317 GSGDTSNFDDYEEEDIRVS(ph)ITEK ddPTM_A459_Selumetinib_30min_R1 1 GSGDTSNFDDYEEEDIRVSITEK 23 1 A0A087WVC4;A0A0A0MS54;P22694-10;P22694-4;P22694-3;P22694;P22694-5;P22694-7;P22694-6;P22694-9;P22694-2 A0A087WVC4 PRKACB cAMP-dependent protein kinase catalytic subunit beta 1 GSGDTSNFDDY(0.049)EEEDIRVS(0.937)IT(0.014)EK 68.458 0.0017551 3768800.0 496.7 428.88 616.41 752.13 486.72 563.33 426.02 480.44 277.92 397.86 True False 508.2721435900433 378.6665302190971 532.7049076977631 620.7846147286896 442.6962619373954 557.663411662716 393.8849684093304 467.6971705109408 471.60994152631645 448.929206484581 1.1321877397333036 0.8434882933643634 1.1866122765083664 1.3828118236945475 0.9861159745074423 1.2422079107518917 0.8773877099547962 1.0418060659793682 1.0505218522522535 1.0 8.810344148090538 -7.261460679195009 24.99999999998977 0.9959127510378594 1.1236045618153152 0.1806059082649668 0.1420634704707248 3.9548291751262945 4636254.966834751 0.058826925461933806 0.04261438677174152 5.4769568681043767e-08 7.261460679195009 0.12769181077745584 GSGGGGGGGGQGST(ph)NYGK ddPTM_A459_Selumetinib_30min_R2 1 GSGGGGGGGGQGSTNYGK 18 0 Q99729-3;Q99729-4 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 GSGGGGGGGGQGS(0.39)T(0.61)NYGK 171.52 1.5152999999999998e-07 1504700.0 4550.8 4563.9 4712.9 4579.2 4718.4 3865.8 4533.9 4773.0 3988.7 6228.6 True False 4297.8847542957965 4913.936454748542 4409.677145017539 3955.505060439393 4125.632408968804 4398.278859761584 4744.735333752411 4786.888639787311 4786.551453589743 6048.764134153691 0.7105393199295467 0.8123868522170558 0.7290211764282186 0.653936072346591 0.6820620406859425 0.7271367774000608 0.7844140106177685 0.7913829227955284 0.7913271781524757 1.0 12.562424689915161 -8.996736638742007 0.6336425480808338 1.0054939331930048 0.7208105436260981 0.7907229373125915 0.04193783446148146 0.8097235815627972 0.5709632340239932 0.057496144790038124 0.01909834602158737 1.0075424691831875e-09 8.996736638742007 -0.28468338956690675 GSGGGGGGGGQGSTNY(ph)GK ddPTM_A459_Selumetinib_30min_R1 1 GSGGGGGGGGQGSTNYGK 18 0 Q99729-3;Q99729-4 Q99729-3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 GSGGGGGGGGQGS(0.015)T(0.196)NY(0.79)GK 148.78 0.0025994 2000700.0 630.69 804.83 809.76 1018.6 836.13 834.97 607.8 684.5 389.78 620.83 True False 645.3838498908885 710.6001294446837 699.7990396932902 840.7206314900928 760.502189130741 826.5709598921026 561.9531566574125 666.3448364306453 661.4281915951627 700.5195778963016 0.9212930948040187 1.0143901068099404 0.9989714231753876 1.2001386656670219 1.0856258884506418 1.1799398417590843 0.8021947913932518 0.9512151515189841 0.9441965827442933 1.0 9.452281560972162 -7.259936173603708 24.998368901543184 0.9203362307887325 1.0681910494149298 0.3738458097321846 0.09016285631576712 153.46663034630933 2552185.7870886056 0.03733311816309025 0.02734067288300483 5.496216434566138e-08 7.259936173603708 0.14785481862619732 GSGGGGGPQVPHQS(ph)PPKR ddPTM_A459_Selumetinib_30min_R1 2 GSGGGGGPQVPHQSPPKR 18 1 Q9NYF3;D6RHW3 Q9NYF3 FAM53C Protein FAM53C 1 GSGGGGGPQVPHQS(1)PPKR;GSGGGGGPQVPHQS(1)PPKR 81.65100000000002 0.0070465000000000015 4969000.0 6489.3 7513.3 8005.5 8632.5 7350.9 6017.1 6239.200000000001 6659.4 3673.0 6257.3 True False 6640.48806402027 6633.639343161595 6918.397071063812 7124.995927094272 6686.012392906802 5956.57343708968 5768.572120791262 6482.771079220216 6232.812734694013 7060.48540626343 0.9405143813666725 0.9395443742829387 0.9798755571290367 1.0091368393416142 0.94696214327921 0.8436492810827909 0.8170220301955304 0.9181764009411141 0.8827739703512197 1.0 12.785551656421438 -6.608611187877444 6.326263490190362 0.8829128499306075 0.9675927806101045 0.3386292637114867 0.04925364423338041 0.21756991682910273 13.004901047008556 0.016300438692891286 0.016291511573052652 2.462571291130766e-07 6.608611187877444 0.08467993067949697 GSGHSQEQPAPQPS(ph)GGDPSPPQER ddPTM_A459_Selumetinib_30min_R2 1 GSGHSQEQPAPQPSGGDPSPPQER 24 0 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 GSGHSQEQPAPQPS(0.939)GGDPS(0.061)PPQER 105.22 4.2217e-07 3663100.0 11468.0 9765.0 12239.0 16317.0 18944.0 13754.0 11879.0 14709.0 14808.0 13674.0 True False 10830.654470041352 10513.944100576155 11451.556064815646 14094.596451604995 16564.08535849122 15648.488653619128 12431.397037791954 14751.800754793956 17770.013770089725 13279.196090681298 0.8156107038468832 0.7917605876724974 0.862368172486872 1.0614043467206502 1.2473710942573624 1.1784213853578445 0.9361558450451463 1.1108956185341716 1.338184453994159 1.0 13.696880189555586 -5.777042645880829 3.1104610608950787 1.134533252379572 0.8084830549431049 0.6306853222303198 0.10736705453244055 0.16134203845734005 3.2119123720931544 0.032053909428530515 0.0550748297828807 1.6709265283383812e-06 5.777042645880829 -0.326050197436467 GSGMSDLEGS(ph)GGR ddPTM_A459_Selumetinib_30min_R2 2 GSGMSDLEGSGGR 13 0 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 GSGMSDLEGS(1)GGR;GSGMSDLEGS(1)GGR 90.689 0.020789 6899900.0 27893.0 24115.0 31024.0 30753.0 38322.0 28483.0 21522.0 24964.0 26318.7 29839.0 True False 26342.818724525925 25964.54295805367 29027.949616377206 26564.388348115986 33507.64775697323 32406.274707069457 22522.81564503395 25036.64110698733 31583.175405919792 28977.470538967333 0.9090793031469578 0.8960251697310142 1.0017420111718167 0.9167255752151878 1.1563344603150907 1.1183265517772247 0.7772526458010366 0.86400367738514 1.089921750190323 1.0 14.822644046212561 -5.2573286568889905 23.656557417794787 0.9859129622136712 0.9025522204409302 0.09161581924669249 0.1100530692336572 464.180678907172 2671223.736359606 0.030399377514798348 0.07432755472181725 5.529315141443283e-06 5.2573286568889905 -0.083360741772741 GSGS(ph)PTHSLSQK ddPTM_A459_Selumetinib_30min_R1 3 GSGSPTHSLSQK 12 0 I3L419;I3L156;Q9BSJ6-2;Q9BSJ6;I3L2R2 I3L419 FAM64A Protein FAM64A 1 GSGS(1)PTHSLSQK;GS(0.001)GS(0.995)PT(0.004)HS(0.001)LSQK;GS(0.06)GS(0.897)PT(0.034)HS(0.009)LSQK 225.63 3.2204e-09 92021800.0 7496.4 7813.6 9154.1 9091.800000000001 8799.8 7474.3 9077.300000000001 7089.499999999999 2568.71 5687.700000000001 True False 7671.051534544795 6898.780079555911 7911.023499871995 7504.0878042230715 8003.8596437308715 7399.115328121419 8392.591952823848 6901.46343005852 4358.913258844501 6417.771697889592 1.195282708025798 1.0749494379528166 1.232674497049099 1.16926686667441 1.2471399763819653 1.1529103365510072 1.3077112038098289 1.0753675504424665 0.6791941913854427 1.0 12.647856753592986 -8.050368412482204 6.048734409165853 0.845779486634474 1.1931986861865567 0.700542529338847 0.09247582448408295 0.10873345873585728 9.292759276426162 0.057923636868358164 0.021981734373422147 8.904952095798213e-09 8.050368412482204 0.34741919955208267 GSGS(ph)PTHSLSQK ddPTM_A459_Selumetinib_30min_R2 2 GSGSPTHSLSQK 12 0 I3L419;I3L156;Q9BSJ6-2;Q9BSJ6;I3L2R2 I3L419 FAM64A Protein FAM64A 1 GS(0.004)GS(0.872)PT(0.029)HS(0.084)LS(0.012)QK;GS(0.002)GS(0.969)PT(0.02)HS(0.008)LS(0.001)QK 138.31 0.0012519 89206000.0 55928.0 48613.0 65299.0 72994.0 78467.0 50196.0 49158.0 52290.0 51886.0 60534.0 True False 52819.7456575229 52341.46078456819 61097.73343217556 63052.091278326574 68609.27395611968 57110.04336608003 51443.94440472904 52442.15524292448 62264.64981596948 58786.2261337796 0.8985054685653948 0.8903694662327007 1.0393205594306338 1.0725657254275713 1.1670977789930894 0.971486811147137 0.875102005828002 0.8920823582650476 1.0591707260519505 1.0 15.843190544538029 -10.31305412404934 14.877080644927448 0.999999923345977 0.9854451773285154 0.0022945394081083093 0.09306483879034502 0.0 0.0 0.09989659735805063 0.024228483679237706 4.8634659085912244e-11 10.31305412404934 -0.01455474601746154 GSGS(ph)QSSVPSVDQFTGVGIR ddPTM_A459_Selumetinib_30min_R2 2 GSGSQSSVPSVDQFTGVGIR 20 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 GS(0.219)GS(0.781)QSSVPSVDQFTGVGIR;GSGS(1)QSSVPSVDQFTGVGIR 175.52 4.9033e-13 4687100.0 13041.9 14092.0 17468.1 16973.7 14421.9 16865.2 14955.2 13074.5 11854.099999999999 13869.5 True False 12317.083408862252 15172.811087078251 16344.221463829239 14661.852778734303 12610.091988578157 19188.22821295747 15650.646433166612 13112.544630400014 14225.251231227763 13469.051497711302 0.9144729612887147 1.126494400118409 1.2134649174521677 1.0885586695711784 0.936227171655027 1.4246161443675516 1.1619709402570784 0.9735314051348111 1.0561435030258037 1.0 13.717360638090646 -7.759721143818918 24.99797214500136 1.0111280797878024 1.1302606556237778 0.12742912395169081 0.13568491355750553 95.9901414935466 1396592.8158202667 0.06938187369831511 0.0373695828443447 1.7389170117390133e-08 7.759721143818918 0.11913257583597536 GSGS(ph)RGRFDDRGR ddPTM_A459_Selumetinib_30min_R2 1 GSGSRGRFDDRGR 13 3 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;O15523;O15523-2;A0A2R8YDH3;A0A2R8YF89;A0A2R8Y650;A0A2R8YCU0;C9J081;C9J8G5;O15523-3;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 GS(0.029)GS(0.971)RGRFDDRGR 69.26100000000001 0.04538 5288200.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GSGSQS(ph)SVPSVDQFTGVGIR ddPTM_A459_Selumetinib_30min_R1 1 GSGSQSSVPSVDQFTGVGIR 20 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 GSGS(0.354)QS(0.581)S(0.064)VPSVDQFTGVGIR 245.1 8.4287e-31 5927300.0 1264.1 1474.1 1190.7 1447.1 1313.0 1257.1 1340.6 1542.9 668.77 1124.3 True False 1293.5510704895796 1301.5116867095014 1029.0094800469276 1194.3911504312898 1194.2393818289775 1244.4547153554754 1239.4774626767476 1501.97727995448 1134.8538449717714 1268.6148566093964 1.0196562524475157 1.0259312981624917 0.8111283536416579 0.9414923246473064 0.9413726913310783 0.9809554955721602 0.9770321198897798 1.1839505679200282 0.8945613706628617 1.0 10.309038427287772 -7.538566070490624 24.995463362584886 1.039651843121647 0.9516467052052238 0.11869677828520042 0.08625671813348798 428.925621619098 683422.049901375 0.039821346336832375 0.02299949099328181 2.8935695763697883e-08 7.538566070490624 -0.08800513791642328 GSGT(ph)ASDDEFENLR ddPTM_A459_Selumetinib_30min_R1 1 GSGTASDDEFENLR 14 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GSGT(0.922)AS(0.078)DDEFENLR 227.92 8.4903e-13 21108000.0 1853.4 2076.7 1909.7 2187.7 2127.0 1928.4 2152.2 1735.9 1016.5 1359.0 True False 1896.5806139113877 1833.5589985683616 1650.373229231224 1805.6592632150748 1934.6132255523503 1909.0020468471093 1989.8578212538403 1689.858293002128 1724.926257777419 1533.440887780992 1.236813645067132 1.1957154743810594 1.076254873847431 1.177521271020759 1.2616157824980694 1.2449140113966726 1.2976423395970085 1.1020041962279252 1.1248730039235626 1.0 10.58255683825826 -8.419332778305535 1.5447891936577263 1.007835398564242 1.2060090255313518 0.5080849527027438 0.06265286346983112 0.3363301227507792 1.7108246264850548 0.0643371841276053 0.01907539005831593 3.807739434081356e-09 8.419332778305535 0.19817362696710972 GSGTAEVELKK ddPTM_A459_Selumetinib_30min_R2 1 GSGTAEVELKK 11 1 P14618;P14618-3;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 89.561 0.039322 24023000.0 51072.0 53338.0 55954.0 62871.0 61507.0 45868.0 53475.0 49374.0 42739.0 60317.0 False True 48233.62269741467 57428.85309129859 52353.980558108866 54307.86134147558 53779.9407804434 52185.90065175231 55961.693458702255 49517.670165694304 51287.9942274355 58575.49148761325 0.8234437556126091 0.9804246047759216 0.8937864493920631 0.927143075751398 0.9181304230595496 0.8909169914995569 0.9553772753325727 0.8453649966584681 0.8755879451439376 1.0 15.838009533866499 -4.73005777831356 24.456567495888606 0.9153410709724883 0.8234429657882306 0.28526418706483514 0.04548743612128236 4394.176743800491 3424251.7888402287 0.010835114483669406 1.4828314726120153 1.8618394220302507e-05 4.73005777831356 -0.09189810518425767 GSGTAS(ph)DDEFENLR ddPTM_A459_Selumetinib_30min_R1 4 GSGTASDDEFENLR 14 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GSGT(0.127)AS(0.873)DDEFENLR;GSGT(0.061)AS(0.939)DDEFENLR;GSGT(0.07)AS(0.93)DDEFENLR;GS(0.002)GT(0.006)AS(0.992)DDEFENLR 281.68 1.0826e-54 637073000.0 6887.33 7684.61 7841.96 7997.860000000001 7862.870000000001 6363.28 7327.21 6934.72 3856.3 5294.19 True False 7047.791388588712 6784.892288721732 6777.064904802897 6601.183889426028 7151.674796802453 6299.271180595971 6774.512650529386 6750.78869845482 6543.859446991703 5973.750856277598 1.1797933255255268 1.1357842755681273 1.1344739792221374 1.1050316707616092 1.197183305575427 1.0544917811522545 1.134046734374651 1.1300753682019833 1.095435615650927 1.0 12.544421353929787 -14.522878736233837 0.15670674997589115 0.518966043727234 1.1658840008460545 0.5891406065782899 0.0349293432421769 93.52461756760468 0.8485086463985525 13.933424286806405 0.15142618517294143 3.000000062491013e-15 14.522878736233837 0.6469179571188205 GSGTAS(ph)DDEFENLR ddPTM_A459_Selumetinib_30min_R2 4 GSGTASDDEFENLR 14 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 GS(0.002)GT(0.34)AS(0.658)DDEFENLR;GSGT(0.001)AS(0.999)DDEFENLR;GSGT(0.004)AS(0.996)DDEFENLR;GSGT(0.047)AS(0.953)DDEFENLR 204.17 2.6861e-05 1095572000.0 103167.0 92021.2 114695.0 106803.0 127507.0 81424.0 90014.0 98027.2 90049.7 97910.0 True False 97433.39115022292 99078.93014520597 107315.64857047418 92256.2471545487 111488.43073295704 92639.41690652048 94199.82935935713 98312.44292272347 108062.156198842 95083.08389926904 1.0247184583689333 1.0420247859248037 1.1286513243950345 0.9702698247806615 1.1725369662080778 0.9742996662230962 0.990710707902074 1.0339635494666497 1.1365024331070601 1.0 16.53690107557307 -5.7514766845573275 24.998095809221105 1.0419316744045104 1.0628207956017233 0.027332954882752003 0.0680985692934171 1224.523276308811 3072511.9450467057 0.018323982415464103 0.0312680137160357 1.7722431868580748e-06 5.7514766845573275 0.020889121197212868 GSHQIS(ph)LDNPDYQQDFFPK ddPTM_A459_Selumetinib_30min_R1 1 GSHQISLDNPDYQQDFFPK 19 0 P00533;E9PFD7 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 GS(0.004)HQIS(0.996)LDNPDYQQDFFPK 89.29700000000003 0.0019479 4444200.0 3944.6 2677.9 5211.2 4196.9 4196.2 4003.6 4395.8 5717.2 1026.0 3025.8 True False 4036.5015051445253 2364.3702230780636 4503.547663072604 3463.990200570162 3816.6544508992815 3963.327418977953 4064.2212669211176 5565.561283917139 1741.0470639248717 3414.1909037878804 1.1822717647880268 0.6925126009957172 1.3190673251680611 1.0145859731296898 1.1178796260820938 1.1608394289202846 1.1903907489215262 1.6301259773559869 0.509944262927203 1.0 11.737328013281987 -5.273269758079596 24.96212306204427 1.1407971971980932 0.9373921516915623 0.05466471668857098 0.2877967938534765 1707.8863818559303 3603644.825139746 0.0707281398720799 0.14908932128878058 5.3300372221643146e-06 5.273269758079596 -0.20340504550653093 GSHQIS(ph)LDNPDYQQDFFPK ddPTM_A459_Selumetinib_30min_R2 2 GSHQISLDNPDYQQDFFPK 19 0 P00533;E9PFD7 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 GS(0.021)HQIS(0.979)LDNPDYQQDFFPK;GS(0.001)HQIS(0.999)LDNPDYQQDFFPK 107.56 0.00051287 4275300.0 46319.0 23517.0 39082.0 42246.0 21491.8 20422.7 46418.0 29281.0 29827.0 34193.0 True False 43744.77540964817 25320.678280926713 36567.50666926426 36492.02192158514 18791.807944870234 23235.74154618781 48576.52897552204 29366.202862269514 35793.23343601205 33205.75924591675 1.3173851886861279 0.7625387539976322 1.1012398902988763 1.0989666476628597 0.5659201407111637 0.6997503467427888 1.4628946929287696 0.8843707696844975 1.0779224522750064 1.0 15.01914586554739 -9.28112402776007 15.446396659344659 1.0000060526495105 0.9849602221058305 0.0 0.2627959150402507 0.0 0.0 0.2538091941768597 0.061557771549652696 5.234509257818126e-10 9.28112402776007 -0.015045830543680028 GSISSGLEFVSHNPPS(ph)EAATPPVAR ddPTM_A459_Selumetinib_30min_R2 1 GSISSGLEFVSHNPPSEAATPPVAR 25 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06;F8VRK6 Q99700;F8WB06 ATXN2 Ataxin-2 1 GSISSGLEFVSHNPPS(0.741)EAAT(0.259)PPVAR 108.99 1.5212e-07 5664700.0 7263.4 5917.9 8771.2 12561.0 12737.0 7163.0 6247.7 7775.9 7235.6 9311.7 True False 6859.729305693961 6371.783900952343 8206.870541360486 10850.170131066396 11136.864189775266 8149.638230760056 6538.230429582688 7798.526581630455 8682.922179555728 9042.84702629787 0.7585807086800102 0.7046214408385213 0.9075538397911358 1.1998621783065198 1.2315661381186367 0.901224825219288 0.7230278705996679 0.8623972692395707 0.9601978397184614 1.0 13.142561343151364 -5.376413732873195 4.6077078494936945 0.9779492060172644 0.7334754176208068 0.3252294509304292 0.14186019260962843 0.2947781259066482 9.766231999349191 0.04381788815771148 0.09579289193817431 4.203260118517268e-06 5.376413732873195 -0.24447378839645761 GSISSGLEFVSHNPPSEAAT(ph)PPVAR ddPTM_A459_Selumetinib_30min_R1 2 GSISSGLEFVSHNPPSEAATPPVAR 25 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06;F8VRK6 Q99700;F8WB06 ATXN2 Ataxin-2 1 GSISSGLEFVSHNPPS(0.062)EAAT(0.938)PPVAR;GSISSGLEFVSHNPPS(0.111)EAAT(0.889)PPVAR 142.96 1.4234e-08 18225500.0 2796.2 2835.7 2682.1000000000004 3145.1 3700.8 2325.6 3159.8999999999996 2858.2 1442.3400000000001 1994.31 True False 2861.3460195419348 2503.6949257188344 2317.8855517207244 2595.8673258388862 3366.0632934293067 2302.206575475853 2921.546198949916 2782.3912512579527 2447.5456356543864 2250.299114724438 1.2715403036064044 1.112605390695106 1.0300344236701897 1.1535654566334241 1.495829275052397 1.0230669160431907 1.2982923824807513 1.2364539598544315 1.08765346777204 1.0 11.135901065059192 -8.488011006396574 3.8695501128266354 1.0008603208129965 1.198697320565399 0.20146345149382716 0.1318691943443992 0.3202702138349114 11.280862283619019 0.127475585330415 0.03348904464277973 3.2507905874891864e-09 8.488011006396574 0.19783699975240254 GSISSGLEFVSHNPPSEAAT(ph)PPVAR ddPTM_A459_Selumetinib_30min_R2 2 GSISSGLEFVSHNPPSEAATPPVAR 25 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06;F8VRK6 Q99700;F8WB06 ATXN2 Ataxin-2 1 GSISSGLEFVSHNPPS(0.239)EAAT(0.761)PPVAR;GSISSGLEFVSHNPPS(0.325)EAAT(0.675)PPVAR 114.87 1.059e-07 9180300.0 31955.0 30748.0 41993.0 43432.0 49991.0 32602.0 31842.0 35829.0 35646.0 38959.0 True False 30179.0690260003 33106.27272959709 39291.216098521385 37516.486675620996 43710.68365478961 37092.62956851029 33322.71609372602 35933.256458189724 42776.196032456704 37834.15244236162 0.7976673739943442 0.8750367219150155 1.0385118619580425 0.9916037297987692 1.155323453363481 0.9804007007959011 0.8807575680330478 0.9497571410627524 1.130623874755065 1.0 15.207401505903409 -5.088271993787565 3.2506442790320613 1.0120912972684957 0.8059333434618958 0.4791290290163739 0.0765188532727734 0.23025962309123596 4.482985619114143 0.02118830826451555 0.07944688293429972 8.160711150457251e-06 5.088271993787565 -0.20615795380659985 GSISTPNS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 GSISTPNSPVK 11 0 Q96AY4;A0A087WW06 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 GSIS(0.005)T(0.109)PNS(0.887)PVK;GSIS(0.002)T(0.043)PNS(0.955)PVK 112.08 0.007875799999999999 9270900.0 6571.1 7101.1 7617.2 8098.700000000001 8882.099999999999 7241.0 6785.9 6328.700000000001 4150.5 5713.6 True False 6724.193844865183 6269.699910788176 6582.826078284591 6684.414076427264 8078.715623262115 7168.1621143019665 6274.0340996405685 6160.842317485206 7043.095359473864 6446.996215176951 1.0429964002515895 0.9724993937531093 1.021068705265854 1.0368261207741063 1.2530976215317007 1.111860760430929 0.9731716741000699 0.9556143841036998 1.092461531603451 1.0 12.654411421189572 -10.253785709001042 5.402482948644189 0.9999999930340712 1.0500861304543945 0.03289162942078894 0.08291802838045853 62425953.93872974 1.0510755883752993e-07 5.443887444758721 0.02200273163584775 5.574607451796553e-11 10.253785709001042 0.05008613742032331 GSISTPNS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 GSISTPNSPVK 11 0 Q96AY4;A0A087WW06 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 GSIST(0.012)PNS(0.988)PVK;GSIS(0.068)T(0.372)PNS(0.56)PVK 156.08 0.00054266 12618000.0 134934.0 112509.0 138122.0 150100.0 143042.0 99692.0 115183.0 127192.0 96735.0 116168.0 True False 127434.9084635994 121138.07852654628 129235.38089586294 129656.1210630573 125071.78514829496 113423.66808612747 120539.23773078452 127562.1076622308 116084.70300173074 112813.92799928797 1.1296026184320407 1.0737865498957793 1.1455622828475454 1.14929178836744 1.108655530096287 1.005404829861463 1.0684783330259124 1.1307301316822858 1.0289926524184443 1.0 16.78358566819354 -6.569116734064612 12.01014094348685 1.0563013850773568 1.1232517820972316 0.4629900870112682 0.0398208708690784 0.8701752676847425 223.9385281843707 0.013342273286266575 0.01334432883637636 2.6970144041917635e-07 6.569116734064612 0.06695039701987482 GSKPS(ph)PLSVK ddPTM_A459_Selumetinib_30min_R1 1 GSKPSPLSVK 10 1 Q96S94;Q96S94-3;A0A0A0MSF3 Q96S94 CCNL2 Cyclin-L2 1 GS(0.012)KPS(0.984)PLS(0.005)VK 126.34 0.016483 75653000.0 3984.4 4643.0 4905.5 5160.8 4630.2 3893.2 3897.3 4273.9 2363.0 3206.7 True False 4077.2287677072063 4099.395401527859 4239.360043982703 4259.563160214084 4211.399227528203 3854.0379427427733 3603.3235232657676 4160.542288416267 4009.838413308456 3618.3111809030975 1.1268319842765893 1.1329582218256549 1.1716405339478286 1.1772241101581915 1.1639129463920446 1.0651482832885701 0.9958578306596645 1.149857510977769 1.1082071753451668 1.0 11.821100772179118 -6.76329320459477 24.906616942575063 1.0689329709988957 1.1555292437396623 0.5012140245937422 0.045089701944098795 44.47069813420757 597467.2218303297 0.016079428639065977 0.014916282816768007 1.724673122821385e-07 6.76329320459477 0.08659627274076653 GSLAEAVGS(ph)PPPAATPT(ph)PTPPTR ddPTM_A459_Selumetinib_30min_R2 1 GSLAEAVGSPPPAATPTPTPPTR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 2 GS(0.003)LAEAVGS(0.997)PPPAAT(0.301)PT(0.664)PT(0.035)PPTR 117.22 0.00030362 0.0 8344.7 9098.1 9472.2 10938.0 11308.0 7935.4 9534.1 8377.4 5435.5 9195.0 True False 7880.934980480821 9795.895014997635 8862.768964551582 9448.225530897553 9887.387945197359 9028.42931961096 9977.454541460747 8401.776847046773 6522.751880559341 8929.51645852088 0.8825713035066458 1.097024128966135 0.9925250718469077 1.0580892677432383 1.107270252664403 1.0110770680080545 1.1173566438684241 0.9408994189186449 0.7304708951328586 1.0 13.124366338868432 -7.993419924829284 10.229788092784409 0.8553281686387414 1.0401374075491399 0.3857737477396712 0.08859260911175675 0.13235605234796413 175.73628222665988 0.046495925620745664 0.02145700778735437 1.01526654405447e-08 7.993419924829284 0.18480923891039847 GSLAEAVGS(ph)PPPAATPTPTPPTR ddPTM_A459_Selumetinib_30min_R1 3 GSLAEAVGSPPPAATPTPTPPTR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 GSLAEAVGS(1)PPPAATPTPTPPTR;GSLAEAVGS(1)PPPAATPTPTPPTR;GS(0.001)LAEAVGS(0.999)PPPAATPTPTPPTR 241.92 2.9073999999999997e-37 50299600.0 6900.500000000001 8725.8 9335.0 9619.699999999999 9950.699999999999 7795.400000000001 9724.0 9069.5 5147.83 7571.799999999999 True False 7061.268223964356 7704.179279485634 8067.358273484564 7939.799979133358 9050.660941938777 7716.985353656886 8990.510851162682 8828.947398112103 8735.491527372691 8543.714285577718 0.8264869338952713 0.9017365307370744 0.944244856959078 0.9293147820423018 1.059335628441697 0.9032354191295467 1.0522953542979758 1.0333851417545499 1.0224465888470433 1.0 13.060647686641635 -2.893018814584636 0.389724056579471 1.0252735945311486 1.6773107885569639e-16 0.6515969642139803 0.04352638204185165 14.444000946880779 0.5304269172266942 0.03213027938453494 9.393591268401424 0.001279325879768235 2.893018814584636 -1.0252735945311484 GSLAEAVGS(ph)PPPAATPTPTPPTR ddPTM_A459_Selumetinib_30min_R2 2 GSLAEAVGSPPPAATPTPTPPTR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 GSLAEAVGS(0.921)PPPAAT(0.073)PT(0.006)PTPPTR;GSLAEAVGS(1)PPPAATPTPTPPTR 155.53 2.2048e-09 80854000.0 130443.0 123013.0 151642.0 164261.0 179971.0 123288.0 134436.0 143951.0 127487.0 154889.0 True False 123193.50026470222 132447.70155086264 141885.518815326 141888.36843396982 157361.43401884648 140269.80290296598 140687.5403798804 144369.8735776289 152987.96228440254 150416.95212004767 0.8190134059250288 0.8805370650321129 0.9432814374678146 0.9433003822649512 1.046168213096463 0.9325398562192427 0.9353170530114037 0.9597978920780644 1.0170925559128665 1.0 17.198607643588836 -5.0087642563066 1.2715965692154902 0.9748756946460053 0.7846334188419903 0.6956123253711087 0.03440414655976028 0.5710289101780037 1.0714377731592943 0.01084961721257968 0.12805162166084036 9.800218164096986e-06 5.0087642563066 -0.19024227580401498 GSLAEAVGSPPPAAT(ph)PTPTPPTR ddPTM_A459_Selumetinib_30min_R1 4 GSLAEAVGSPPPAATPTPTPPTR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 GSLAEAVGSPPPAAT(0.933)PT(0.025)PT(0.035)PPT(0.007)R;GSLAEAVGSPPPAAT(0.498)PT(0.498)PT(0.003)PPTR;GSLAEAVGS(0.003)PPPAAT(0.764)PT(0.108)PT(0.108)PPT(0.016)R;GSLAEAVGS(0.259)PPPAAT(0.728)PT(0.011)PT(0.002)PPTR 256.8 5.844299999999997e-54 42266700.0 5420.95 7664.3 7404.299999999999 7445.5 7246.799999999999 5651.06 6973.4 6048.66 3380.38 5350.37 True False 5547.2475876674935 6766.960192963598 6398.836728908598 6145.283194344671 6591.3282195264555 5594.215467151949 6447.390823683453 5888.229887983324 5736.257966813215 6037.142106517136 0.9188532404561426 1.1208880085261896 1.059911563453345 1.0179126291744558 1.0917961020680749 0.9266330605524351 1.0679541262948657 0.975333988184068 0.9501611632797057 1.0 12.559650045387782 -6.752136476522904 24.999654654745473 0.9877209408032028 1.045933147138878 0.182795736076252 0.060609856040985906 341.3276976591415 917248.6516912559 0.019364412699361577 0.01911245855128427 1.7695527910807094e-07 6.752136476522904 0.05821220633567514 GSLAEAVGSPPPAAT(ph)PTPTPPTR ddPTM_A459_Selumetinib_30min_R2 2 GSLAEAVGSPPPAATPTPTPPTR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 GSLAEAVGSPPPAAT(0.996)PT(0.003)PTPPTR;GSLAEAVGSPPPAAT(0.993)PT(0.007)PTPPTR 258.83 4.625299999999999e-54 46175000.0 57952.0 54582.0 61275.0 75672.0 79728.0 52286.0 61509.0 56726.0 51758.0 55155.0 True False 54731.25984023685 58768.263891208146 57332.63321117565 65365.343058518854 69711.85586263657 59487.92189494907 64369.29037777123 56891.06326850517 62111.046239350646 53562.531840100004 1.0218198796805544 1.0971898054903153 1.0703869149115377 1.2203557377319976 1.3015041199088027 1.1106256528824683 1.201759666065312 1.0621429068801642 1.1595987737243356 1.0 15.708936536380948 -5.683039281319305 9.691682872207467 1.1601158149062754 1.06599918812215 0.19065162316932616 0.08122598541309302 0.5461113811539255 62.8453407577296 0.022094150818645925 0.03828606929091485 2.0747258529602067e-06 5.683039281319305 -0.09411662678412536 GSLAEAVGSPPPAATPT(ph)PTPPTR ddPTM_A459_Selumetinib_30min_R1 1 GSLAEAVGSPPPAATPTPTPPTR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 GSLAEAVGS(0.007)PPPAAT(0.285)PT(0.705)PT(0.003)PPTR 171.83 3.4398e-12 34232000.0 1394.0 2316.9 2038.2 2168.8 1966.9 1867.5 2085.2 1832.6 1006.4 1747.7 True False 1426.4774877481786 2045.6362709024122 1761.4236350311987 1790.0597934181358 1788.9942422843992 1848.714645554332 1927.9116851958493 1783.9934948762607 1707.7872954522334 1972.0343190396168 0.7233532773622697 1.037322855465639 0.8932013089351377 0.9077224347139644 0.9071821037859228 0.9374657569117044 0.9776258286086749 0.9046462719498045 0.8660028271130332 1.0 10.94546894361799 -4.742103493005952 24.999504487123108 0.9319172386353199 0.7233525752145991 0.6139233225580762 0.0506460633422562 926.7657499002663 1198160.137973629 0.012219190610891408 0.4566942719097271 1.8109084990708636e-05 4.742103493005952 -0.20856466342072089 GSLAPQDS(ph)DSEVSQNR ddPTM_A459_Selumetinib_30min_R1 1 GSLAPQDSDSEVSQNR 16 0 J3KN34;P26045-2;P26045;P26045-3 J3KN34 PTPN3 Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 3 1 GSLAPQDS(0.765)DS(0.235)EVSQNR 171.33 9.1102e-07 0.0 852.59 910.97 841.33 1019.8 1006.3 760.69 732.83 782.39 522.97 806.56 True False 872.4536881486516 804.3132089015371 727.0820070948876 841.7110740168822 915.2803426766943 753.0381492512586 677.5520430951826 761.6384756391119 887.4418937824469 910.0898325597036 0.9586456819265883 0.8837734255741976 0.798912350278553 0.9248659241137763 1.0057032942587567 0.8274327679645381 0.7444891909071338 0.8368827432089205 0.9751146118031475 1.0 9.829865146725508 GSLAPQDS(ph)DSEVSQNR ddPTM_A459_Selumetinib_30min_R2 2 GSLAPQDSDSEVSQNR 16 0 J3KN34;P26045-2;P26045;P26045-3 J3KN34 PTPN3 Tyrosine-protein phosphatase non-receptor type;Tyrosine-protein phosphatase non-receptor type 3 1 GSLAPQDS(0.999)DS(0.001)EVSQNR;GSLAPQDS(1)DSEVSQNR 258.68 5.500999999999999e-39 16649900.0 50190.0 41242.0 50357.0 50228.0 44133.0 39389.0 49852.0 47070.0 40321.0 39403.0 True False 47400.64072648894 44405.12878606881 47117.08544455606 43386.859751867116 38588.61798597409 44814.47721225853 52170.216779863986 47206.96590714201 48386.32666287059 38265.33300871107 1.2387358739488357 1.1604532169094155 1.2313256344542955 1.1338424715130568 1.008448508136318 1.1711508482640554 1.3633807072314639 1.2336745088928243 1.264495114987121 1.0 15.223750334494554 -7.02173546924766 24.582351493347122 1.2394897948847614 1.151181887326978 0.0520303831520007 0.10402478301147422 1287.3386105265508 1455948.9227789724 0.038824902744338946 0.030376877814023387 9.511839877544656e-08 7.02173546924766 -0.0883079075577835 GSLAS(ph)LDSLR ddPTM_A459_Selumetinib_30min_R2 3 GSLASLDSLR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;E9PKY0 O60716-5 CTNND1 Catenin delta-1 1 GSLAS(0.998)LDS(0.001)LR;GSLAS(1)LDSLR;GS(0.499)LAS(0.501)LDSLR 152.69 0.00062396 113523600.0 51894.0 47084.0 53659.0 60545.0 67489.0 48230.0 52437.0 58013.0 47993.0 53011.0 True False 49009.93922814144 50695.19140107809 50206.63835950183 52298.66655404942 59010.428460684896 54873.2447116512 54875.424401944285 58181.80822543082 57592.94103646113 51480.43469088095 0.9520109828603074 0.9847467626387009 0.9752566904489491 1.0158940356289068 1.1462690401706686 1.0659048440663466 1.065947184235115 1.130173211916117 1.118734551918283 1.0 15.651736614998713 -6.042653615686574 4.594299248632936 1.0920700638286882 0.9744442852444598 0.6429356970861272 0.03956192832007579 0.12382505151003105 5.915334113425242 0.011411907095873385 0.015572681036945351 9.064552826829491e-07 6.042653615686574 -0.1176257785842284 GSLEMS(ph)SDGEPLSR ddPTM_A459_Selumetinib_30min_R1 1 GSLEMSSDGEPLSR 14 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 GSLEMS(0.499)S(0.499)DGEPLS(0.001)R 121.18 0.0019576 2363300.0 1165.4 1259.0 962.96 818.83 959.12 1144.2 1029.4 837.85 474.24 942.31 True False 1192.551552526348 1111.595694706779 832.1953211606534 675.8367118427572 872.3677653463891 1132.6903868504774 951.7515292253051 815.6274962796434 804.7506428808297 1063.264667376679 1.1215942644540702 1.0454553121278298 0.7826793710862909 0.6356241607371412 0.8204615389870173 1.0652948617629585 0.8951219375825752 0.767097338324978 0.756867661996459 1.0 10.054285041253458 -5.1461952105931665 4.443636496018745 0.8344703474778578 1.1031906108978857 0.4099310304675151 0.11764051545900246 0.22673644774562537 7.121356295694927 0.03278688121065761 0.09664182826638493 7.141752400028369e-06 5.1461952105931665 0.26872026342002797 GSLEMS(ph)SDGEPLSR ddPTM_A459_Selumetinib_30min_R2 1 GSLEMSSDGEPLSR 14 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 GSLEMS(0.5)S(0.5)DGEPLSR 136.33 0.00084787 0.0 14257.0 12917.0 15340.0 18512.0 19336.0 10908.0 14808.0 15329.0 10284.0 13697.0 True False 13464.65301529295 13907.692365298744 14353.041100929153 15990.633665018786 16906.83881396675 12410.477987034856 15496.601341495336 15373.604852147446 12341.087358968314 13301.53202092013 1.012263323812345 1.0455707164727543 1.0790517271510718 1.2021648062696342 1.2710444772358804 0.9330111725112671 1.1650237970425426 1.1557770058342482 0.9277944329689793 1.0 13.699304799087612 -8.263849962476119 24.989676007428848 0.9638972048724711 1.1095862600518616 0.2736196912054035 0.09387978511013688 302.80237477303064 3138943.173659266 0.07996811999294817 0.024365622066934513 5.446907969398219e-09 8.263849962476119 0.14568905517939046 GSLGIS(ph)QEEQ ddPTM_A459_Selumetinib_30min_R1 2 GSLGISQEEQ 10 0 H3BRR0;Q9NZD8-2;Q9NZD8 H3BRR0 SPG21 Maspardin 1 GS(0.001)LGIS(0.999)QEEQ;GS(0.002)LGIS(0.998)QEEQ 90.913 0.028769 26480000.0 9106.6 10166.0 11278.7 12516.5 12287.2 10388.6 10768.4 10777.599999999999 5528.5 7985.200000000001 True False 9318.766061641008 8975.759993954816 9747.11448946443 10330.728238803991 11175.824929481358 10284.100116094107 9956.13091831142 10491.743037421356 9381.46071433593 9010.178202434714 1.0342488075455498 0.9961800746104448 1.0817893132047691 1.1465620331474067 1.2403555932402588 1.141386983147032 1.1049871261837079 1.1644323565749561 1.0412070109557754 1.0 13.137339924466323 -5.486979632066997 3.6812998842417977 1.131570778507935 1.0165898154880277 0.28602403588865477 0.06346198980068075 0.24950448710779974 7.033601837405737 0.017145016769096137 0.03639656629979966 3.2585198274285528e-06 5.486979632066997 -0.11498096301990723 GSLGIS(ph)QEEQ ddPTM_A459_Selumetinib_30min_R2 2 GSLGISQEEQ 10 0 H3BRR0;Q9NZD8-2;Q9NZD8 H3BRR0 SPG21 Maspardin 1 GS(0.005)LGIS(0.995)QEEQ;GS(0.001)LGIS(0.999)QEEQ 109.16 0.010241 24134500.0 146398.0 132595.0 177280.0 158612.0 178873.0 138127.0 118895.0 134604.0 114204.0 125756.0 True False 138261.78523762777 142764.6101398766 165873.9978078695 137008.77197903837 156401.37459509066 157152.74045793584 124423.85308597302 134995.67535510828 137047.99112637277 122125.0975266723 1.1321324448271675 1.169003038942889 1.3582302177620975 1.1218723649257718 1.2806652994560137 1.2868177274013104 1.0188229578183032 1.1053884753346872 1.1221935040538353 1.0 16.89800018873848 -7.26346632383615 24.998284123081913 1.0703836046635347 1.2261788282184414 0.5204261369997356 0.0765499976677131 160.00948569250295 1973373.302088859 0.030923585377391604 0.022025901529778437 5.451721679171469e-08 7.26346632383615 0.15579522355490671 GSLGS(ph)QGAKDEPEEELQK ddPTM_A459_Selumetinib_30min_R2 2 GSLGSQGAKDEPEEELQK 18 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 GS(0.06)LGS(0.94)QGAKDEPEEELQK;GS(0.03)LGS(0.97)QGAKDEPEEELQK 83.723 0.0046872 23280000.0 82607.0 65520.0 68482.0 72777.0 66832.0 50824.0 60392.0 69200.0 53175.0 64623.0 True False 78016.03364202175 70545.17331999472 64075.94267756392 62864.647052672495 58435.96667433942 57824.54466566369 63200.34766447775 69401.36054332327 63811.48583363869 62757.16607928171 1.2431414373214904 1.124097497182622 1.021013960327912 1.001712648612192 0.9311441278358031 0.9214014634219366 1.0070618482777913 1.105871486543033 1.0167999898692852 1.0 15.937492585652834 -4.947508096452203 1.7041393188774492 0.9965527644326436 1.2845194209242299 0.7303880447967954 0.04746608144945975 0.39431511787819 1.4744474284158098 0.01542963503630946 0.16874910109264088 1.1284748994334901e-05 4.947508096452203 0.28796665649158626 GSLLTILGS(ph)PSPER ddPTM_A459_Selumetinib_30min_R2 1 GSLLTILGSPSPER 14 0 Q96A19 Q96A19 CCDC102A Coiled-coil domain-containing protein 102A 1 GSLLTILGS(0.942)PS(0.058)PER 81.128 0.03255 2469600.0 15290.0 14169.0 15765.0 16304.0 13004.0 10512.0 13221.0 13678.0 10540.0 16112.0 True False 14440.243010719581 15255.716739484236 14750.697063634176 14083.367074031245 11370.32126276498 11959.93258156494 13835.802696914503 13717.80071548521 12648.294512205957 15646.804695996567 0.9228876624512544 0.9750052509690752 0.9427290331941274 0.9000794314020327 0.7266864694536783 0.7643690078540472 0.88425739093264 0.8767157884315564 0.8083627780847922 1.0 13.933580447575917 -6.012562832171982 13.606256371426586 0.8333294675599913 0.9449878641877211 0.29646179623015334 0.07099385536338505 1.8046975698553342 1955.9532013800124 0.020604675083276947 0.028161088242457853 9.714873900892185e-07 6.012562832171982 0.1116583966277298 GSLLTILGSPS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 GSLLTILGSPSPER 14 0 Q96A19 Q96A19 CCDC102A Coiled-coil domain-containing protein 102A 1 GSLLTILGS(0.01)PS(0.99)PER;GSLLTILGS(0.015)PS(0.984)PER 128.95 0.0010925999999999998 8291600.0 29353.0 34302.0 34382.0 36734.0 36405.0 26563.1 27160.0 27235.0 25015.5 32406.0 True False 27721.677769368995 36932.853101685956 32169.899552291165 31730.76583031547 31831.47843517068 30221.92590918643 28422.993816519007 27314.249341003037 30019.298991469448 31470.35457910036 0.8808822823934471 1.1735760081398408 1.0222286968973453 1.008274811475688 1.011475048848358 0.9603300094132712 0.9031672568250908 0.8679358623795927 0.9538913492701933 1.0 14.94170581324228 -6.816637159253469 2.1085382976929337 0.9204796861700348 1.031301180312641 0.23524452756857983 0.0735655832137326 0.38247219325928145 3.4922594889368597 0.02870379660007125 0.02545235022935973 1.5253265887858348e-07 6.816637159253469 0.11082149414260622 GSLPQLVS(ph)PIVSR ddPTM_A459_Selumetinib_30min_R1 1 GSLPQLVSPIVSR 13 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 GSLPQLVS(0.916)PIVS(0.084)R 152.94 0.00042499 62718000.0 2146.2 2399.3 2790.3 2504.8 2652.0 1845.2 2415.8 2559.2 1181.6 1812.3 True False 2196.202284221766 2118.3888405956923 2411.39258602078 2067.3837009192835 2412.127068248629 1826.638963307552 2233.5742610282614 2491.321702546834 2005.0888993505168 2044.9263582969052 1.0739762218385456 1.0359242678841352 1.1792075427249529 1.0109819811022835 1.1795667156726088 0.8932541535768792 1.0922516852335307 1.2182940928110997 0.9805188784501919 1.0 10.997833174561222 GSLPQLVS(ph)PIVSR ddPTM_A459_Selumetinib_30min_R2 4 GSLPQLVSPIVSR 13 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 GSLPQLVS(1)PIVSR;GSLPQLVS(0.925)PIVS(0.075)R;GSLPQLVS(1)PIVSR;GSLPQLVS(1)PIVSR 147.75 0.00056482 132401000.0 114186.0 102757.0 125650.0 129877.0 121854.0 84957.0 99702.0 112492.0 84429.0 89870.0 True False 107839.9992427749 110638.13148416819 117565.81579737595 112187.52854967816 106545.61113141841 96659.05558713971 104338.34055576511 112819.33309594689 101317.15914336199 87275.21958969798 1.2356313710782618 1.267692387418845 1.3470698366624734 1.2854453884745176 1.2208002641793996 1.1075200502680762 1.1955093444196991 1.2926846088309831 1.1608926293130923 1.0 16.413284461239478 -6.431970975877227 3.7943275702341785 1.1716006284773945 1.2866887539650198 0.39754262972599186 0.07470115663384792 0.28269075891932993 7.490409256574458 0.024279830312432218 0.027265554021387833 3.698528964129372e-07 6.431970975877227 0.11508812548762526 GSLPQLVSPIVS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GSLPQLVSPIVSR 13 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 GSLPQLVS(0.394)PIVS(0.606)R 134.02 0.0012636 56412000.0 2053.9 1810.2 2063.3 2443.2 2387.0 1661.9 2364.6 2426.7 895.74 1805.5 True False 2101.751873806302 1598.2609424608522 1783.115192895631 2016.5409845440745 2171.0962714590787 1645.182794884468 2186.2363182496183 2362.33603296749 1520.0053577388544 2037.2535120592956 1.0316594676927615 0.7845174559769436 0.8752544454289458 0.9898331123777107 1.0656976456820497 0.8075493723024608 1.0731292425358139 1.1595690074818399 0.7461051600801528 1.0 10.992409802439509 -5.763376887087365 24.718210939642223 0.9846498384034065 0.8858811435366403 0.07183613371721853 0.12851597086256503 100.16746849564475 1277945.6891319747 0.034892731274301786 0.05485376392753774 1.7243408343672725e-06 5.763376887087365 -0.0987686948667662 GSLQAHDT(ph)SSLPTVIMR ddPTM_A459_Selumetinib_30min_R2 1 GSLQAHDTSSLPTVIMR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GSLQAHDT(0.881)S(0.073)S(0.047)LPTVIMR 123.14 0.0020277 0.0 9091.6 6748.5 12887.0 12068.0 16135.0 11492.0 9168.3 8993.3 17024.0 9783.2 True False 8586.325268558421 7266.088250152396 12057.864450304705 10424.317581538831 14107.97705126984 13074.918686010687 9594.6441166418 9019.469014079039 20429.27569030304 9500.733596193753 0.9037539240125975 0.7647923369899966 1.2691508848469772 1.0972118601152117 1.484935548231967 1.376200958971089 1.0098845546501451 0.9493444819558438 2.1502840263290355 1.0 13.213823199656135 -5.268732628920562 22.411844330056333 1.2831648719578412 0.8342730899425576 0.23138974202177587 0.333465648323436 176.78405292036248 543259.4061783415 0.08458816602009991 0.1829331379512791 5.386012674625081e-06 5.268732628920562 -0.4488917820152837 GSLQAHDTS(ph)SLPTVIMR ddPTM_A459_Selumetinib_30min_R1 1 GSLQAHDTSSLPTVIMR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GSLQAHDT(0.034)S(0.711)S(0.108)LPT(0.147)VIMR 162.92 8.9433e-06 18476000.0 5289.2 5540.4 5159.2 5597.2 7837.8 5167.0 6287.0 4512.0 1188.1 3235.4 True False 5412.428069008369 4891.727392337917 4458.608977457053 4619.754092456651 7128.872373875982 5115.024671260638 5812.766528307265 4392.327102958467 2016.118924609299 3650.695105464769 1.4825746639061808 1.3399441068128182 1.221304121174871 1.26544506155589 1.952743838619853 1.4011097951192628 1.592235549774087 1.2031481611223955 0.5522561776225428 1.0 11.83395546912874 -8.046024806506635 4.698708190021624 0.7880565036061696 1.4574499456212757 0.610063315174642 0.2183344993509254 0.14338041827784162 6.996649125791479 0.15503723519029758 0.05819907003452736 8.994462045118925e-09 8.046024806506635 0.6693934420151061 GSLQAHDTS(ph)SLPTVIMR ddPTM_A459_Selumetinib_30min_R2 2 GSLQAHDTSSLPTVIMR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GSLQAHDT(0.04)S(0.349)S(0.349)LPT(0.263)VIMR;GSLQAHDT(0.097)S(0.432)S(0.432)LPT(0.04)VIMR 159.75 1.9536e-05 14472800.0 48623.0 47097.0 65429.0 66650.0 87126.0 75846.0 53004.0 66019.0 55950.0 78412.0 True False 45920.72831329096 50709.188459276535 61219.36937370885 57572.155022336934 76180.4529636774 86293.09803856311 55468.791025433486 66211.10435996624 67141.5633736169 76148.04182115693 0.603045425923643 0.6659289884088329 0.8039519849701465 0.756055620675739 1.0004256333025159 1.1332280643701003 0.7284335840927962 0.8695050164976164 0.8817240964817866 1.0 16.21651931723077 -5.517824997744708 1.2821425321044815 0.9214525627941137 0.6055288179215748 0.5322752224011336 0.10748243479750581 0.47902722217352733 1.413338627738522 0.03773649619225857 0.140235747422857 3.0351139600036543e-06 5.517824997744708 -0.31592374487253894 GSLQAHDTSS(ph)LPTVIMR ddPTM_A459_Selumetinib_30min_R1 1 GSLQAHDTSSLPTVIMR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GSLQAHDT(0.007)S(0.046)S(0.868)LPT(0.079)VIMR 137.99 0.00033741 15295000.0 3517.6 3978.8 4078.7 4002.4 5508.1 4065.5 4337.1 3644.4 1112.2 2788.1 True False 3599.5532359418908 3512.960246306063 3524.8349426953932 3303.455974352979 5009.893327534041 4024.604761178653 4009.9490551807576 3547.738673320442 1887.3221681259693 3145.9797933938075 1.1441755740137094 1.1166506071281423 1.1204251693215377 1.0500563230856896 1.5924747317367505 1.2792850003772611 1.2746264497951274 1.127705486465705 0.5999155404904782 1.0 11.619293689025296 -8.094103221017297 5.656217841655477 0.8060211992950276 1.2251447344726791 0.49977497444041674 0.16764431864287463 0.1921073592777124 9.098343186498221 0.12029795988781627 0.044316718387852706 8.051870454824457e-09 8.094103221017297 0.41912353517765155 GSLQAHDTSS(ph)LPTVIMR ddPTM_A459_Selumetinib_30min_R2 2 GSLQAHDTSSLPTVIMR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GSLQAHDTS(0.048)S(0.818)LPT(0.134)VIMR;GSLQAHDT(0.001)S(0.139)S(0.647)LPT(0.213)VIMR 116.98 0.0010591 15709100.0 56779.0 57706.0 84979.0 106549.0 113629.0 101583.0 65371.0 74324.0 64509.0 95675.0 True False 53623.450484345834 62131.86464596491 79511.54365813926 92036.84239272287 99353.9091638513 115575.13617133853 68410.88103017914 74540.27053499945 77412.6025320582 92912.61415649639 0.5771385400267152 0.6687129106206586 0.8557669416578336 0.9905742425641106 1.0693263779717315 1.2439122203221056 0.7362927160240265 0.8022621170624725 0.8331764554774994 1.0 16.50358685501235 -5.274802021085723 2.2863568912461867 0.952647998744075 0.5878274655615128 0.48036340606684513 0.13690482099391985 0.31459897979988194 3.077447335574986 0.04246751137488258 0.1473249811960405 5.311265101342129e-06 5.274802021085723 -0.36482053318256225 GSLS(ph)PGGER ddPTM_A459_Selumetinib_30min_R2 1 GSLSPGGER 9 0 E7EWN3;Q9C0A6;Q9C0A6-2;Q9C0A6-3;H0Y3R4;H7C1F2 E7EWN3 SETD5 SET domain-containing protein 5 1 GS(0.005)LS(0.995)PGGER 93.442 0.024562 5341600.0 49622.0 41423.0 58966.0 45452.0 55425.0 48028.0 77664.0 272120.0 61885.0 155790.0 True False 46864.207892604776 44600.01090406206 55172.191757326545 39261.35919092663 48462.015994213274 54643.42104522456 81275.52988829646 272911.824148109 74263.72921137254 151291.9379089689 0.30976011372663215 0.2947943659158991 0.3646737064768329 0.25950727932740125 0.32032120590174784 0.36117867085622934 0.537209920182259 1.8038755264825665 0.4908637580943435 1.0 17.206975585265447 -7.54079503935043 24.921244293374752 1.1225307598412313 0.3278495835237015 0.5781834293097659 0.2978022408701329 147.6247339483649 205340.7935176682 0.12724580083724835 0.07348286181085074 2.8787566927211316e-08 7.54079503935043 -0.7946811763175298 GSLS(ph)PVTKPR ddPTM_A459_Selumetinib_30min_R2 1 GSLSPVTKPR 10 1 F5H4P8;H0YFK8;F5H4N6;Q9Y3R0-3;Q9Y3R0-2;Q9Y3R0;F5H4Q7 F5H4P8 GRIP1 Glutamate receptor-interacting protein 1 1 GS(0.095)LS(0.9)PVT(0.005)KPR 69.846 0.041667 18680000.0 184070.0 143180.0 196470.0 191850.0 210540.0 142390.0 158710.0 160170.0 130230.0 187950.0 True False 173840.12629059216 154161.44560373714 183829.33410036168 165719.69904029043 184090.08294851892 162002.93001227482 166090.32947789878 160636.06818242904 156279.63893022624 182523.3951472542 0.9524265431855645 0.8446119768885763 1.0071549126732706 0.9079367546642059 1.0085834903520219 0.8875735073938106 0.9099673460703613 0.8800848135266871 0.856217027982329 1.0 17.477721869386876 GSLSLS(ph)FEREPSTSDLGTTDVQK ddPTM_A459_Selumetinib_30min_R1 1 GSLSLSFEREPSTSDLGTTDVQK 23 1 P57078-2;P57078 P57078-2 RIPK4 Receptor-interacting serine/threonine-protein kinase 4 1 GS(0.096)LS(0.345)LS(0.521)FEREPS(0.009)T(0.009)S(0.009)DLGT(0.009)T(0.001)DVQK 48.896 0.029969 8375600.0 935.35 1123.2 1040.9 1206.8 840.76 1026.2 1050.7 822.42 454.7 1033.3 True False 957.1418351257237 991.6952218384869 899.5514972544285 996.0550344416285 764.7134064482342 1015.8773597150496 971.4448530765765 800.6067500033466 771.5926900259643 1165.9341201943341 0.8209227421581851 0.8505585389963494 0.7715285809669025 0.8542978691417052 0.6558804594557832 0.8712991086886851 0.8331901745140275 0.6866655123446461 0.6617806929754811 1.0 10.187270557630969 GSLSLS(ph)PPLNK ddPTM_A459_Selumetinib_30min_R2 2 GSLSLSPPLNK 11 0 Q9H7X7-3;Q9H7X7-2;Q9H7X7 Q9H7X7-3 IFT22 Intraflagellar transport protein 22 homolog 1 GSLS(0.007)LS(0.993)PPLNK;GSLS(0.014)LS(0.986)PPLNK 113.99 0.0067818 13585300.0 153542.0 117778.0 153912.0 174857.0 167296.0 137455.0 182821.0 181511.0 158317.0 144578.0 True False 145008.75031732552 126811.19388404103 144009.46948671536 151041.17495485028 146278.78083478395 156388.17855774454 191322.53875293885 182039.1669592363 189984.82374657554 140403.65748124334 1.0327989520977927 0.9031901031565496 1.0256817526705366 1.0757638202909923 1.0418445178632578 1.1138468994558535 1.3626606470596951 1.296541487771108 1.3531330105980737 1.0 17.099220992424897 -7.014933828868561 3.1976670511403347 1.2771697071780397 1.0140345448233932 0.5270399447899355 0.10439063657649368 0.17789270591359607 3.7428567223131 0.04001390001674697 0.03217339353822026 9.661980822183422e-08 7.014933828868561 -0.2631351623546465 GSLTLHER ddPTM_A459_Selumetinib_30min_R1 2 GSLTLHER 8 0 P17041 P17041 ZNF32 Zinc finger protein 32 0 ; 103.74 0.021316 2916100.0 2159.8 2394.7 2655.7 2580.7 2503.1 1987.24 2294.7 2377.6 1587.58 1921.91 False True 2210.1191377607724 2114.3274107341736 2295.070526715903 2130.0291907387405 2276.695046958198 1967.250169869553 2121.6089315264303 2314.538324466766 2694.007307744492 2168.605869488719 1.0191428368133306 0.9749708051987601 1.0583161094445437 0.9822113002216151 1.0498427026276391 0.9071497027412185 0.9783285019082935 1.067293212211241 1.242276130323139 1.0 11.082552160723624 -7.978641921953258 5.6767408146102145 1.132321531962872 0.9966452856615312 0.36061552314849155 0.0677069502507469 0.14962948978599802 15.16658111554603 0.037813217162721735 0.01685886482059309 1.0504081386557078e-08 7.978641921953258 -0.1356762463013409 GSMES(ph)LALSNATGLSADGGAK ddPTM_A459_Selumetinib_30min_R2 1 GSMESLALSNATGLSADGGAK 21 0 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 GS(0.065)MES(0.906)LALSNATGLS(0.028)ADGGAK 166.79 3.5833e-10 2523700.0 21196.0 21301.0 21997.0 18885.0 21100.0 16211.0 19551.0 18563.0 15548.0 16736.0 True False 20018.01117431082 22934.718206489764 20581.73696852274 16312.830421557894 18449.229363606664 18443.91810119379 20460.160239571545 18617.01525672993 18658.034447417285 16252.788194649873 1.231666279937149 1.411125151685633 1.2663511467711046 1.0036942724035367 1.1351424224970716 1.134815631650525 1.258870785402019 1.1454659369066484 1.1479897617541817 1.0 13.988399615816075 -1.5228787725222743 0.29296510550270877 1.1021069568029846 3.015943417980619 0.320634227372259 0.0972107291122416 68.62544302697495 0.9752804169427081 0.10864252650716753 68.27351615523396 0.029999998118193733 1.5228787725222743 1.9138364611776344 GSNRSS(ph)LMDTADGVPVSSR ddPTM_A459_Selumetinib_30min_R1 1 GSNRSSLMDTADGVPVSSR 19 1 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 GS(0.333)NRS(0.13)S(0.498)LMDT(0.038)ADGVPVSSR 146.15 0.00022546 7113000.0 1547.7 1541.4 2159.7 2692.4 1798.7 2204.0 1739.9 1214.8 626.31 1323.2 True False 1583.7583987000414 1360.9321714225816 1866.424602382926 2222.222882607426 1636.007902586278 2181.8297610718873 1608.6579421984745 1182.579557773481 1062.8023261274725 1493.045609059462 1.0607568778141503 0.9115141313599222 1.250078759187184 1.4883824506923846 1.0957521275032411 1.4613282727821837 1.07743389246618 0.7920585617732347 0.7118351373050019 1.0 10.54404252177478 -7.634434889699875 4.24988238024662 0.815650676340001 1.2110595915209335 0.47169497065182076 0.1772581792975876 0.19466802015563112 6.2402492521622355 0.09379642027700229 0.05149122460689146 2.3204120403223565e-08 7.634434889699875 0.39540891518093246 GSPALLPS(ph)TPTMPLFPHVLDLLAPLDSSR ddPTM_A459_Selumetinib_30min_R1 1 GSPALLPSTPTMPLFPHVLDLLAPLDSSR 29 0 Q9UGR2 Q9UGR2 ZC3H7B Zinc finger CCCH domain-containing protein 7B 1 GS(0.198)PALLPS(0.267)T(0.267)PT(0.267)MPLFPHVLDLLAPLDSSR 90.744 3.6047e-06 35151000.0 1637.7 1910.5 1831.1 2042.3 1902.0 1812.5 1770.8 1819.2 965.39 1206.8 True False 1675.8552235905258 1686.8177718326456 1582.4466775123292 1685.6506437190417 1729.964435825374 1794.2678956183286 1637.2271303207408 1770.9489064055938 1638.196320704125 1361.7045352274474 1.2307040038686552 1.2387546110000243 1.1621072241255412 1.2378975028070132 1.2704403863474065 1.3176631561402778 1.2023365480289543 1.3005383037149023 1.2030482959583406 1.0 10.411197983750208 -8.555111050223521 21.509371158109364 0.9999999992148135 1.2441909818094918 0.7484692858787072 0.042429718132673655 920.3378628593301 614162.6209256593 0.04217802129843189 0.01089031827912542 2.785408841308827e-09 8.555111050223521 0.2441909825946783 GSPCS(ph)PTPR ddPTM_A459_Selumetinib_30min_R2 1 GSPCSPTPR 9 0 A6NHQ4 A6NHQ4 C17orf96 Uncharacterized protein C17orf96 1 GS(0.003)PCS(0.865)PT(0.132)PR 91.658 0.026926 5884500.0 21308.0 18612.0 14774.0 19339.0 22260.0 17041.0 17955.0 17614.0 15772.0 21704.0 True False 20123.786662682334 20039.480552987534 13823.456924714952 16704.994838364222 19463.4997930751 19388.243067203977 18789.943077157543 17665.253823845316 18926.84070650021 21077.349126235702 0.9547588998102975 0.9507590557506922 0.6558441880866517 0.792556727049273 0.9234320538367993 0.9198615514258747 0.8914756293413129 0.8381155390103951 0.8979706410490359 1.0 14.363405811850999 -6.2722622093214495 24.425879848075134 0.9031009497822917 0.8334542742772533 0.13952311400684647 0.08727052691623399 1229.3576230109668 2774512.3564158813 0.028932884468825075 0.03314162424142696 5.342417086185021e-07 6.2722622093214495 -0.06964667550503845 GSPDGS(ph)LQTGKPSAPK ddPTM_A459_Selumetinib_30min_R1 3 GSPDGSLQTGKPSAPK 16 1 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 GS(0.014)PDGS(0.977)LQT(0.009)GKPSAPK;GS(0.004)PDGS(0.99)LQT(0.005)GKPSAPK;GS(0.026)PDGS(0.972)LQT(0.002)GKPSAPK 88.76799999999999 0.0075242999999999985 206356800.0 8767.1 12357.900000000001 9197.6 9907.0 9660.3 8700.2 11605.3 10381.7 5521.6 9940.8 True False 8971.356372193008 10911.031322968158 7948.616438800388 8176.928427422288 8786.527570664488 8612.683887149558 10729.902877519367 10106.343591485802 9369.751918291988 11216.798511591833 0.7998143465732841 0.9727402441696992 0.7086350379376084 0.728989507921709 0.7833364896038904 0.7678379778551704 0.9565922813386288 0.9010007250323301 0.8353321055565862 1.0 13.453373341545175 -7.257087570205237 24.974960940460157 0.914981339615352 0.7944437293672815 0.4012898455108279 0.07732801564487791 437.18433346277965 2509002.4658034067 0.031698215753835635 0.02366790463244635 5.532385441381259e-08 7.257087570205237 -0.12053761024807053 GSPDGS(ph)LQTGKPSAPK ddPTM_A459_Selumetinib_30min_R2 1 GSPDGSLQTGKPSAPK 16 1 Q8IZL8;C9JFV4;E7EV54 Q8IZL8 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 1 GS(0.036)PDGS(0.964)LQTGKPSAPK 112.02 0.0013855 6528400.0 29630.0 20114.0 32646.0 34686.0 30310.0 27270.0 32418.0 33852.0 23425.0 28526.0 True False 27983.283218287874 21656.679123296326 30545.591902277287 29961.706963312547 26502.18682516201 31026.194967587126 33925.50123504837 33950.503715499704 28110.654549186384 27702.38026055104 1.0101400296687446 0.7817623944082538 1.1026342002017444 1.081557132690827 0.9566754400127077 1.1199830005860287 1.224642103529249 1.2255446425968735 1.0147378775684752 1.0 14.757722321259296 -5.605653179479137 0.8844060249666321 1.1230068007878928 0.8861008597868619 0.2637020080482477 0.10715381811400186 1.0497818731256923 1.3639759019944702 0.045033587597503706 0.1910013821340794 2.4794012768393333e-06 5.605653179479137 -0.2369059410010309 GSPS(ph)PPQAEAR ddPTM_A459_Selumetinib_30min_R1 2 GSPSPPQAEAR 11 0 M0R0S1;M0R2P6;Q8TBC3;M0R1G0;M0QZE8;M0R0K4;M0QYB1;M0R0E3;M0R0S2;M0QZF4 M0R0S1 SHKBP1 SH3KBP1-binding protein 1 1 GS(0.01)PS(0.99)PPQAEAR;GS(0.192)PS(0.808)PPQAEAR 117.95 0.005450899999999999 15461300.0 4551.8 5091.4 5873.299999999999 6400.700000000001 5673.1 4219.2 5021.8 4091.8 2835.4 3895.2999999999997 True False 4657.848083738999 4495.296521072357 5075.738119727574 5282.937901019667 5159.969106667155 4176.758678727087 4643.001582925626 3983.272171960429 4811.466710577569 4395.299698435098 1.0597338983272013 1.0227508542074757 1.15481047209016 1.2019516900976293 1.1739743500322195 0.950278471389375 1.056356085246865 0.9062572396095385 1.0946845586640297 1.0 12.101745825162691 -6.7619656732602245 24.999999390353647 0.9990838957890827 1.1232876033604273 0.4364747910645548 0.06878720920797754 14.301440053746024 679331.4337217807 0.02455219671510642 0.022975262127249686 1.7299530897176106e-07 6.7619656732602245 0.12420370757134458 GSPS(ph)PPQAEAR ddPTM_A459_Selumetinib_30min_R2 1 GSPSPPQAEAR 11 0 M0R0S1;M0R2P6;Q8TBC3;M0R1G0;M0QZE8;M0R0K4;M0QYB1;M0R0E3;M0R0S2;M0QZF4 M0R0S1 SHKBP1 SH3KBP1-binding protein 1 1 GS(0.006)PS(0.994)PPQAEAR 96.23 0.020438 8611800.0 14825.0 14356.0 17382.0 19147.0 17840.0 13845.0 12708.0 13097.0 11502.0 13769.0 True False 14001.085849177105 15457.059038184465 16263.661044090657 16539.145569582688 15598.779708376442 15752.023077603375 13298.947180424286 13135.110101674925 13802.721392731777 13371.453193841657 1.0470878255495395 1.1559745088367324 1.216297197344342 1.23689963460366 1.1665732573899 1.178033744668688 0.9945775517166104 0.9823248012956751 1.032252904201074 1.0 13.706868643905267 -7.261450054358947 24.99999999989485 1.0008158733825652 1.1717428725262835 0.7342661286483567 0.048429437054888586 0.5257313554462626 1228425.8049463169 0.020650836534876826 0.014945892442032436 5.477090861242891e-08 7.261450054358947 0.17092699914371834 GSPSVAAS(ph)SPPAIPK ddPTM_A459_Selumetinib_30min_R1 1 GSPSVAASSPPAIPK 15 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 GSPSVAAS(0.5)S(0.5)PPAIPK 115.12 0.002411 12078000.0 3499.1 3964.6 4367.5 4858.9 3569.2 3431.9 3488.6 3400.9 2106.8 3067.4 True False 3580.6222219366236 3500.4227889074623 3774.41748896024 4010.3843278492145 3246.366490193442 3397.3782019158853 3225.4520933120266 3310.6970843199124 3575.0857254161015 3461.1306690061924 1.0345238490995028 1.0113523942488285 1.0905157446840927 1.1586919742041208 0.9379497050672125 0.9815804506714528 0.9319070563256611 0.9565362885506213 1.0329242283252569 1.0 11.757027693651333 -6.2834359302897935 24.99363839860204 0.9696358460211236 1.0705085855471486 0.5377063721315469 0.045431384566163954 655.4839543726641 744793.4169076782 0.014836541219280956 0.016836212866827086 5.206718157451722e-07 6.2834359302897935 0.10087273952602493 GSPSVAAS(ph)SPPAIPK ddPTM_A459_Selumetinib_30min_R2 3 GSPSVAASSPPAIPK 15 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 GSPSVAAS(0.654)S(0.346)PPAIPK;GSPSVAAS(0.592)S(0.408)PPAIPK;GSPS(0.002)VAAS(0.636)S(0.362)PPAIPK 198.81 2.4029e-05 22474600.0 183902.0 172473.0 178972.0 201466.0 198199.0 140787.0 140116.0 163688.0 126005.0 159420.0 True False 173681.46305803495 185701.12451189672 167457.13636997988 174025.98325176537 173299.46969845888 160179.1313128598 146631.67163458673 164164.30497999265 151209.52087386238 154817.1303770961 1.1218491302286124 1.1994869305455726 1.0816447505653661 1.1240744666167193 1.1193817459110913 1.0346344162477576 0.947128210408166 1.0603755836329556 0.9766976077230829 1.0 17.240205587668157 -6.8163345276946785 3.278608158908497 0.9997954139235274 1.131916413022514 0.738252491965152 0.03790044071853662 0.12613826895285085 2.7574961987141258 0.013751453854987833 0.012400396130628606 1.5263898600303529e-07 6.8163345276946785 0.13212099909898645 GSPSVAASS(ph)PPAIPK ddPTM_A459_Selumetinib_30min_R1 1 GSPSVAASSPPAIPK 15 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 GSPS(0.003)VAAS(0.177)S(0.821)PPAIPK 101.45 0.0069337 18174000.0 3799.6 4834.4 4999.7 5230.2 5043.3 3992.6 4506.9 4767.9 2486.4 3814.7 True False 3888.1232872654114 4268.386200548415 4320.768201386268 4316.843753013432 4587.134405466932 3952.438068990749 4166.940904473992 4641.439803678119 4219.239200529047 4304.353903324613 0.9033000944142366 0.9916438788296619 1.0038134173978994 1.0029016781541062 1.0656963875400447 0.9182418912947538 0.9680758130170278 1.0783127753721982 0.980225905047021 1.0 12.071580985600564 -4.756274315259076 3.76034077073118 1.002842517240147 0.8900423318437898 0.319007289941724 0.04305136562200112 0.356724891836124 8.653591329606888 0.010975226483746726 0.11659432479973542 1.752773040679913e-05 4.756274315259076 -0.11280018539635717 GSPSVAASS(ph)PPAIPK ddPTM_A459_Selumetinib_30min_R2 1 GSPSVAASSPPAIPK 15 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 GSPSVAAS(0.148)S(0.852)PPAIPK 180.95 2.0314e-05 15368000.0 89094.0 74897.0 89025.0 96943.0 89699.0 67582.0 69807.0 76109.0 64222.0 87124.0 True False 84142.51215154023 80641.35906818749 83297.22842309104 83739.19616399705 78430.20970076573 76890.80705168584 73053.16381994625 76330.46458947683 77068.19451260826 84608.50374466286 0.9944923787503803 0.9531117499909031 0.9845018495359631 0.9897255294421793 0.9269778595477542 0.9087834395905642 0.8634257856681986 0.9021606719323623 0.9108800073476037 1.0 16.368515051094533 -6.402717450279409 3.6963346276475804 0.9082448438685982 0.9786903028253646 0.43110840501553727 0.03403813593793707 0.20674117595250735 5.059910277049552 0.0106298204683267 0.0120715145406541 3.956239272174874e-07 6.402717450279409 0.07044545895676646 GSPTDAEGS(ph)PGLSR ddPTM_A459_Selumetinib_30min_R1 2 GSPTDAEGSPGLSR 14 0 Q8TER5;Q8TER5-4;Q8TER5-3;G3V485;G3V3N2;G3V5C1 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 GSPTDAEGS(0.999)PGLS(0.001)R;GSPT(0.028)DAEGS(0.972)PGLSR 222.88 4.353e-09 31000000.0 3882.8 4849.9 5435.5 5522.9 5230.9 4090.0 5113.200000000001 4596.3 2141.5 4276.4 True False 3973.261685386389 4282.07145334266 4697.3889550643125 4558.429192672915 4757.766018590405 4048.8583134228747 4727.507207339061 4474.391193113474 3633.969091028376 4825.317595663453 0.8234197245290522 0.8874175364521057 0.9734880371990207 0.9446899820168536 0.9860005946274382 0.8390863882331003 0.9797297511748667 0.927273926411526 0.7531046441988087 1.0 12.236408186340112 -4.886602632803109 3.653726990065127 0.9248790737488058 0.822127779058928 0.15748464351336722 0.07221709885847577 0.4547550823644912 10.393334790766009 0.017878294567096376 0.1056337051905551 1.298366696563313e-05 4.886602632803109 -0.10275129468987787 GSPTDAEGS(ph)PGLSR ddPTM_A459_Selumetinib_30min_R2 2 GSPTDAEGSPGLSR 14 0 Q8TER5;Q8TER5-4;Q8TER5-3;G3V485;G3V3N2;G3V5C1 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 GSPTDAEGS(1)PGLSR;GSPT(0.183)DAEGS(0.817)PGLSR 191.63 7.5896e-05 35324000.0 92617.0 68443.0 82832.0 88085.0 87206.0 52823.0 62419.0 72601.0 56492.0 52196.0 True False 87469.71791522659 73692.3580210686 77502.67930066265 76087.67104489937 76250.40264846837 60098.88877054839 65321.60718090207 72812.25689025743 67791.97851836239 50688.96585850526 1.7256165406765696 1.4538145881053428 1.5289852138038487 1.5010697053337572 1.5042801003539132 1.1856404594702183 1.288675080948442 1.4364518126786765 1.3374109605549855 1.0 15.629384110333712 -1.5228787452853392 0.04148346985500664 1.3597959836960577e-14 3.7362115065459185 0.7261434867656928 0.1006739594618506 409.47047793788744 1.2967855708864617 31.329534765104555 105.9404785786277 0.0299999999996545 1.5228787452853392 3.7362115065459047 GSPVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 GSPVSPR 7 0 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 GSPVS(1)PR 90.601 0.029436 6722000.0 3638.0 5577.8 4978.3 6165.4 5110.0 4612.2 4911.4 4246.7 2325.2 3223.4 True False 3722.75832168427 4924.74858295113 4302.274203844481 5088.728628891631 4647.801402243773 4565.8054555425415 4540.929143809176 4134.0637207743175 3945.6945741112236 3637.1547885748746 1.0235358509839327 1.35401127233322 1.1828680531713682 1.3990959760295267 1.2778673640295892 1.2553233835097612 1.2484838858311065 1.1366202323201493 1.0848299848292249 1.0 11.828594609399104 -8.128113463994412 1.3843846503584871 1.0091141519378537 1.2605405670426484 0.43699915189946004 0.09591602416751974 0.3647299112433733 1.2790785680932946 0.08451020245024812 0.02723552563901876 7.445374302709291e-09 8.128113463994412 0.2514264151047947 GSPVSSPQNSPGT(ph)QR ddPTM_A459_Selumetinib_30min_R1 2 GSPVSSPQNSPGTQR 15 0 A0A2R8Y6F3;Q9P2P5;A0A2R8YE75 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 GSPVSS(0.003)PQNS(0.113)PGT(0.884)QR;GSPVSS(0.001)PQNS(0.394)PGT(0.605)QR 210.67 1.2805999999999996e-29 0.0 922.54 1261.12 920.28 1230.26 1077.45 858.54 1191.71 977.09 600.12 718.8499999999999 True False 944.0333870496448 1113.4674841212172 795.3110307361948 1015.4181858403696 979.9948377392479 849.90386709195 1101.8183552487753 951.1743991643809 1018.3598089693903 811.1213996919545 1.1638620154864208 1.3727507183808576 0.9805080115482538 1.2518695551935906 1.2081974882075948 1.0478133944126296 1.3583889608475637 1.1726658913519177 1.255496167843852 1.0 9.663774047036236 -5.2017896062688 24.999962256709903 1.1737034007859428 1.2683060109594542 0.10166053414508536 0.12379932403400074 631.3229764939783 264592.178428969 0.029688717350052348 0.0785489407543841 6.283626950636367e-06 5.2017896062688 0.09460261017351135 GSQEDDPAATQRPPS(ph)NGGAK ddPTM_A459_Selumetinib_30min_R2 1 GSQEDDPAATQRPPSNGGAK 20 1 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 GSQEDDPAAT(0.001)QRPPS(0.999)NGGAK 70.02 0.006294699999999999 10076000.0 82860.0 64530.0 77077.0 82638.0 100940.0 85425.0 90078.0 92800.0 78846.0 77863.0 True False 78254.97291486093 69479.24350334665 72117.94973509245 71382.56184149858 88259.01478495063 97191.51833905879 94266.80548617087 93070.03263613294 94617.40314130853 75614.89287763038 1.0349148155443804 0.9188566016457469 0.9537532487390132 0.9440278115188089 1.167217348674719 1.285348886182335 1.2466698278436417 1.2308426170324764 1.2513064495698014 1.0 16.2063827907771 -6.337183679114898 4.0981291848897525 1.220186618904538 0.9583880188817183 0.6745045303429101 0.079270512121375 0.11842592549022833 3.799013661937119 0.023679202364227818 0.027418593265994207 4.600619553012102e-07 6.337183679114898 -0.26179860002281974 GSQPPPAAESQSS(ph)LRR ddPTM_A459_Selumetinib_30min_R1 3 GSQPPPAAESQSSLRR 16 1 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 GSQPPPAAES(0.303)QS(0.303)S(0.395)LRR;GSQPPPAAESQS(0.01)S(0.99)LRR;GSQPPPAAES(0.003)QS(0.01)S(0.987)LRR 201.75 1.0009e-06 10141900.0 3856.3 4668.4 3187.44 2909.8900000000003 3067.54 2964.7200000000003 3869.9799999999996 3176.79 2032.23 3402.1800000000003 True False 3946.144286946416 4121.821557719722 2754.6031553546495 2401.7323369003593 2790.081548618175 2934.897608550384 3578.0642928612288 3092.5312095317886 3448.5458817934154 3838.8829430395417 1.027940769619286 1.0737033712354238 0.717553308143753 0.6256331262340397 0.7267951615135863 0.7645186508934283 0.9320587123785018 0.8055810128670376 0.8983201449385518 1.0 11.906470854205878 -10.336336652557407 15.295055958332192 0.9999999774589579 0.8341811794498991 0.1082045884052999 0.135242161552413 0.0 0.0 0.1450500012459246 0.035179792713701204 4.609601130457137e-11 10.336336652557407 -0.16581879800905874 GSQPPPAAESQSS(ph)LRR ddPTM_A459_Selumetinib_30min_R2 4 GSQPPPAAESQSSLRR 16 1 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 GSQPPPAAES(0.198)QS(0.198)S(0.603)LRR;GSQPPPAAES(0.037)QS(0.26)S(0.704)LRR;GSQPPPAAES(0.132)QS(0.215)S(0.652)LRR;GSQPPPAAES(0.002)QS(0.138)S(0.861)LRR 167.97 7.101900000000001e-06 41815400.0 116043.0 72287.0 90558.0 110438.0 105906.0 98696.0 123137.0 118307.0 104798.0 76435.0 True False 109593.79461693481 77831.18046066031 84731.59687209527 95396.15388382367 92601.14146834743 112290.47812691523 128863.11449133662 118651.25378322187 125760.52830077441 74228.1229480201 1.4764457225151755 1.0485403290497233 1.1415026206634709 1.2851753499226561 1.2475209905711 1.512775396537363 1.7360416695647267 1.5984676571480874 1.694243681587382 1.0 16.179678266539995 -6.781190079186067 4.094145848474688 1.5654857729749991 1.222909183756776 0.2596094679942469 0.21725731191580366 0.2307038330971586 8.630956610259558 0.07348930546606666 0.06765089808451487 1.655045435398815e-07 6.781190079186067 -0.3425765892182231 GSRAS(ph)LGALSLEAYLT(ph)TGEAET(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GSRASLGALSLEAYLTTGEAETR 23 1 O00763-2;O00763 O00763-2 ACACB Acetyl-CoA carboxylase 2;Biotin carboxylase 3 GS(0.103)RAS(0.448)LGALS(0.448)LEAY(0.052)LT(0.801)T(0.266)GEAET(0.881)R 62.739 0.036684 0.0 0.0 169.33 290.51 116.5 194.5 134.67 61.865 181.92 60.411 0.0 True False 0.0 149.50476488061872 251.06033765720412 96.155461975845 176.90750934176404 133.31534207057663 57.19847324220275 177.09489064055944 102.51305475513202 0.0 0.0 GSRPPLILQSQSLPCS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 2 GSRPPLILQSQSLPCSSPR 19 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 GSRPPLILQSQSLPCS(0.648)S(0.352)PR;GSRPPLILQSQSLPCS(0.827)S(0.172)PR 131.86 0.00014233 62653000.0 2749.0699999999997 3023.31 3542.54 3563.7 3490.95 3061.56 3179.71 3029.95 1697.76 2508.86 True False 2813.1179822409517 2669.3394597013116 3061.4825257793277 2941.3666939340674 3175.194188877279 3030.7634860740663 2939.8619147007907 2949.585883335329 2880.974720515685 2830.8966193658734 0.993719785808037 0.9429307454891267 1.0814533122954897 1.0390229985130788 1.1216213856613841 1.070601965942848 1.0384914428133818 1.041926385851576 1.0176898374907908 1.0 11.467043349535748 -5.261074054040268 24.99998177370243 1.0551459351242887 0.9683252620779053 0.4805847062874158 0.03434505717021241 24.998996898962922 1710533.216716805 0.00893489732206628 0.02086678166033879 5.481834830446698e-06 5.261074054040268 -0.08682067304638341 GSRPPLILQSQSLPCS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 GSRPPLILQSQSLPCSSPR 19 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 GSRPPLILQS(0.025)QS(0.139)LPCS(0.418)S(0.418)PR;GSRPPLILQSQSLPCS(0.63)S(0.37)PR 112.41 0.00031537 38419100.0 54537.0 48667.0 60600.0 59345.0 63707.0 48115.0 48400.0 47159.0 42990.0 50302.0 True False 51506.051868908704 52399.60241093082 56701.06197629119 51262.108624164866 55703.557112193885 54742.40450551722 50650.69590278058 47296.22488240726 51589.20124096147 48849.65055970827 1.0543791261301563 1.0726709773877192 1.1607260507828248 1.0493853699425726 1.1403061531444973 1.1206304216773528 1.036869155100115 0.968199861012265 1.056081274888644 1.0 15.576060621628901 -7.422318433924057 4.557037426069031 1.0078817689815582 1.10040936101742 0.5372545884373376 0.03896038366111997 0.17253695617500486 5.910812482809301 0.01683980437360332 0.010941727653595554 3.78165204291516e-08 7.422318433924057 0.0925275920358617 GSS(ph)FEMTDDDSAIR ddPTM_A459_Selumetinib_30min_R1 2 GSSFEMTDDDSAIR 14 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 1 GS(0.003)S(0.997)FEMTDDDSAIR;GS(0.002)S(0.995)FEMT(0.003)DDDSAIR 297.03 8.064099999999997e-80 11585000.0 2035.4900000000002 2464.2 2601.8 3001.9 2752.0 2112.98 2684.5 2034.5300000000002 999.55 2021.02 True False 2082.9129566259253 2175.690318424499 2248.4898506643976 2477.674517641968 2503.0820859050623 2091.7253396323385 2482.0060036966497 1980.5676553151793 1696.1633457564392 2280.4376034018705 0.9133830075064165 0.9540670243197561 0.9859905166053153 1.086490818229741 1.0976323501116887 0.9172473460847961 1.08839022825886 0.8685033312731922 0.7437885356855047 1.0 11.155094980841435 -7.860579842251401 7.486631072105561 0.8511759971588921 1.0063517326705207 0.3336957302312532 0.08659799436912428 0.24028613617480193 15.838486530302477 0.0471695291591873 0.022540196779448917 1.3785424934868793e-08 7.860579842251401 0.15517573551162855 GSS(ph)FEMTDDDSAIR ddPTM_A459_Selumetinib_30min_R2 2 GSSFEMTDDDSAIR 14 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 1 GS(0.005)S(0.991)FEMT(0.004)DDDSAIR;GS(0.004)S(0.996)FEMTDDDSAIR 203.85 3.0592e-05 5405100.0 20873.0 21041.5 25488.0 24834.0 28851.0 21566.3 18071.9 24212.0 21088.3 21545.0 True False 19712.962221239362 22655.315390913776 23848.129829236128 21451.5663589605 25226.479448787508 24536.862065620608 18912.279158790498 24282.45291148763 25306.54925633328 20922.939869367317 0.942169807126414 1.0827979018418334 1.13980778887347 1.025265402132476 1.2056852242700788 1.1727253540284905 0.9039016159712541 1.160566013337298 1.209512115139416 1.0 14.352797957566878 -4.770349272009956 4.036046858633123 1.1047405117777864 0.9260982076417437 0.20538886903610343 0.09369027996819604 0.37901103632853533 11.760953559346174 0.023435535436971505 0.2013229588808507 1.6968784255273435e-05 4.770349272009956 -0.17864230413604276 GSS(ph)FQSGR ddPTM_A459_Selumetinib_30min_R2 1 GSSFQSGR 8 0 Q96KP1 Q96KP1 EXOC2 Exocyst complex component 2 1 GS(0.041)S(0.959)FQSGR 111.27 0.011672 22997000.0 69895.0 51251.0 63889.0 74457.0 60063.0 54008.0 100510.0 144620.0 85616.0 97067.0 True False 66010.51571185378 55181.78690206128 59778.45129708366 64315.82815451081 52517.34896996716 61447.11176418939 105183.91415678673 145040.8202568701 102741.59231091334 94264.42349964626 0.7002696591265047 0.5853935647553009 0.6341570772700688 0.6822916405440295 0.5571279918787626 0.6518589886079341 1.1158389374458058 1.5386591767297486 1.0899296733226072 1.0 16.524425763122785 -7.315188935034747 3.915525889755169 1.2486238093332156 0.6286621268360556 0.7932143254945846 0.13769323103781092 0.08929987879200176 2.840165451733465 0.056746090274062286 0.03792767952724344 4.8396177953444286e-08 7.315188935034747 -0.61996168249716 GSS(ph)GEGLPFAEEGNLTIK ddPTM_A459_Selumetinib_30min_R1 1 GSSGEGLPFAEEGNLTIK 18 0 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 GS(0.001)S(0.999)GEGLPFAEEGNLTIK 132.25 0.00049296 2955500.0 984.37 863.15 982.34 1080.9 1170.5 755.09 1178.0 1160.1 658.11 977.77 True False 1007.3039057494082 762.0919967324511 848.9436236073728 892.14110600593 1064.628481668559 747.494480166865 1089.1425115867585 1129.330379464121 1116.7646035473658 1103.2763037863288 0.9130114571412861 0.6907535257641546 0.7694750813498733 0.8086289018845009 0.9649699517834885 0.6775224643197195 0.9871892542683418 1.0236151865025809 1.012225677026459 1.0 10.107578428431655 -7.391813487173682 6.992246154942019 1.0116220547335386 0.8051978178988397 0.5895585314175249 0.08259371910279996 0.17966542624677012 9.397224597310853 0.03437435212376796 0.023025235800437083 4.05682723215345e-08 7.391813487173682 -0.2064242368346989 GSS(ph)GSPAHAESYSSGGGGQQK ddPTM_A459_Selumetinib_30min_R1 2 GSSGSPAHAESYSSGGGGQQK 21 0 P15408 P15408 FOSL2 Fos-related antigen 2 1 GS(0.11)S(0.445)GS(0.445)PAHAESYSSGGGGQQK;GS(0.088)S(0.456)GS(0.456)PAHAESYSSGGGGQQK 132.36 3.0884e-05 25346000.0 6888.0 6631.2 6053.4 7099.4 9074.5 6365.5 8201.1 6666.1 1605.71 4167.5 True False 7048.476998285118 5854.816021238754 5231.381528946059 5859.623062243041 8253.713077233102 6301.46884941157 7582.484424256509 6489.293373455551 2724.7725935816834 4702.4392198876285 1.4988980545406285 1.2450593718420593 1.1124825402998129 1.2460816159965307 1.7551982473960261 1.3400425938013831 1.6124577202802641 1.3799845293078816 0.579438131184776 1.0 12.199193581364648 -10.073930980437586 7.772540786851794 1.0000631262182156 1.3235363244937046 0.08320351841974472 0.3023907853761048 0.0 0.0 0.2941636311763984 0.07134516015032512 8.434687940548927e-11 10.073930980437586 0.32347319827548904 GSS(ph)GSPAHAESYSSGGGGQQK ddPTM_A459_Selumetinib_30min_R2 2 GSSGSPAHAESYSSGGGGQQK 21 0 P15408 P15408 FOSL2 Fos-related antigen 2 1 GS(0.116)S(0.442)GS(0.442)PAHAESYSSGGGGQQK;GS(0.109)S(0.445)GS(0.445)PAHAESYSSGGGGQQK 142.22 8.7951e-06 82818000.0 76846.0 66274.0 88306.0 117308.0 129966.0 76690.0 70946.0 79877.0 84269.0 102192.0 True False 72575.20695891154 71357.00269550261 82624.48810030332 101330.44803241252 113638.5091692183 87253.35137749375 74245.12957683201 80109.42884565073 101125.15467258832 99241.4514332972 0.7312993301764762 0.7190241745251331 0.8325602548833884 1.0210496377163467 1.145071011437169 0.8792026932026384 0.7481261963075391 0.8072174246614521 1.0189810125918726 1.0 16.598655214742585 -5.49584407198249 4.165237101242339 0.9350843997602505 0.7307212818427254 0.39826828268393444 0.10854071291170854 0.24981197025917057 9.811497473390968 0.03333095632134238 0.0686418603698546 3.1926839426969213e-06 5.49584407198249 -0.20436311791752504 GSS(ph)GSVDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R1 1 GSSGSVDETLFALPAASEPVIR 22 0 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 GS(0.376)S(0.621)GS(0.004)VDETLFALPAASEPVIR 247.28 2.5648e-44 7648200.0 617.27 778.38 614.91 574.9 553.83 488.98 468.07 628.48 269.42 629.18 True False 631.6511900016628 687.2469077409556 531.4085994588534 474.50450720955604 503.73617428662806 484.06130515831705 432.7631030546809 611.8106688092505 457.1860623417533 709.9413817321891 0.8897230197519889 0.9680333129252712 0.7485246150354937 0.6683713887079105 0.7095461502153317 0.6818327788940176 0.6095758244135315 0.861776316400223 0.6439771988305049 1.0 9.471556099215302 -5.319474594981468 5.776269147548872 0.723975826493175 0.9286201851621021 0.3081432498390826 0.11098787307874725 0.19784303890782243 14.189423775661913 0.027150096960716463 0.05864684394831397 4.792094845095144e-06 5.319474594981468 0.20464435866892705 GSS(ph)GSVDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R2 1 GSSGSVDETLFALPAASEPVIR 22 0 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 GS(0.405)S(0.585)GS(0.01)VDETLFALPAASEPVIR 154.46 4.0689e-08 1431900.0 8972.4 4864.9 7145.7 8252.6 7329.3 5548.1 9131.2 6466.7 6120.8 7605.4 True False 8473.749927363011 5238.022186880997 6685.953441649903 7128.581643470939 6408.527809226654 6312.300414362672 9555.818893129537 6485.517026380186 7345.131029441191 7385.81234079769 1.1473010058156745 0.7092005517046855 0.9052427997280796 0.9651723215460184 0.8676808336744871 0.8546521524104855 1.2938074313566272 0.8781047672380653 0.9944919652058062 1.0 12.850540891581467 GSS(ph)LSGTDDGAQEVVK ddPTM_A459_Selumetinib_30min_R2 2 GSSLSGTDDGAQEVVK 16 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 GS(0.001)S(0.987)LS(0.012)GTDDGAQEVVK;GS(0.01)S(0.929)LS(0.056)GT(0.005)DDGAQEVVK 219.85 9.0374e-11 18885700.0 83769.0 44095.0 83334.0 84132.0 85400.0 77574.0 85323.0 96316.0 88290.0 82625.0 True False 79113.45433387639 47476.9447122279 77972.38116719892 72673.07646420496 74671.2885143132 88259.11435334083 89290.68856431697 96596.26361402779 105950.46702871566 80239.40156446837 0.9859676516943195 0.5916911615309411 0.9717467933076743 0.9057031214996757 0.9306062490298925 1.0999473155645239 1.112803520756275 1.2038507482688228 1.3204294269765924 1.0 16.29202322573891 -6.665148122687263 0.9842494473636116 1.1929541870635216 0.8216196348478982 0.5438538485591393 0.1257843944134226 0.3725469825139515 0.7806196572678451 0.06708341342985688 0.06767552517277514 2.1619810217108082e-07 6.665148122687263 -0.3713345522156234 GSS(ph)PDVHALLEITEESDAVLVDKSDSD ddPTM_A459_Selumetinib_30min_R1 1 GSSPDVHALLEITEESDAVLVDKSDSD 27 1 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 GS(0.133)S(0.867)PDVHALLEITEESDAVLVDKSDSD 199.27 3.4369e-40 8415000.0 1911.5 1992.1 2720.7 2222.1 2047.1 1926.6 1855.1 1726.2 1006.8 1334.0 True False 1956.0342308684685 1758.8640058978353 2351.243883735348 1834.0519489830501 1861.9401664448585 1907.220153212838 1715.1683134504221 1680.4155685121693 1708.4660662373888 1505.2318942603708 1.2994902900523573 1.1685003570576693 1.5620476105382313 1.2184514266383204 1.2369789489211989 1.26706068379583 1.1394711472634642 1.1163831798407906 1.1350185129294523 1.0 10.555770048675454 -7.573460256673786 0.5991231122813009 1.0204937310157933 1.3241574930161857 0.5052446919775284 0.09972146698616009 0.670035947636969 0.49198852642090546 0.09449799859446616 0.0585644804013209 2.6701751100565535e-08 7.573460256673786 0.30366376200039236 GSS(ph)PGPRPVEGTPASR ddPTM_A459_Selumetinib_30min_R1 2 GSSPGPRPVEGTPASR 16 1 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 GS(0.029)S(0.971)PGPRPVEGTPASR;GS(0.129)S(0.871)PGPRPVEGTPASR 180.56 4.7920999999999986e-06 148660400.0 4651.7 5252.4 5579.7 5777.3 5518.799999999999 4392.1 5111.6 4892.0 2579.5 3759.7 True False 4760.075559367435 4637.446566225488 4822.007387098215 4768.403008352358 5019.625514423278 4347.919461707728 4726.027896627228 4762.248268544509 4377.223100774083 4242.294117579248 1.122052226327873 1.0931459341795289 1.1366508906388049 1.1240151852256106 1.1832337351677051 1.0248981662282182 1.1140264596562224 1.1225643806285546 1.0318056644483264 1.0 12.050628930816645 -8.37901842887084 3.489473621216444 1.001444628247443 1.1147264875254426 0.5346814189798352 0.037456495208353084 0.18069007810002544 3.822150264586798 0.03574192061011532 0.009546493497536194 4.178126367909389e-09 8.37901842887084 0.11328185927799961 GSS(ph)PGPRPVEGTPASR ddPTM_A459_Selumetinib_30min_R2 1 GSSPGPRPVEGTPASR 16 1 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 GS(0.173)S(0.827)PGPRPVEGTPASR 114.54 0.0098757 61518000.0 21475.0 19868.0 22641.0 24461.0 21804.0 15898.0 20872.0 17810.0 16145.0 21791.0 True False 20281.5054712363 21391.811714311 21184.302709656928 21129.369602421382 19064.786589766823 18087.805192324893 21842.589357083376 17861.824151395784 19374.451128991004 21161.837210182563 0.9584000325584838 1.0108674167485694 1.0010616043990526 0.9984657472109483 0.9009041323025258 0.8547369972027514 1.0321688585040836 0.8440582910637413 0.915537291803213 1.0 14.369177263095917 -6.2550762257817745 24.584517773782665 0.9186590424237301 0.9941652498179829 0.2569077787301143 0.055768521615983266 519.7949242893728 2008265.2962867385 0.016107809238808665 0.020271154770613403 5.558066955469656e-07 6.2550762257817745 0.07550620739425284 GSS(ph)PGSLEIPK ddPTM_A459_Selumetinib_30min_R2 2 GSSPGSLEIPK 11 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 GS(0.015)S(0.981)PGS(0.004)LEIPK;GS(0.038)S(0.961)PGSLEIPK 131.12 0.0022643 8220800.0 93464.0 82540.0 100713.0 109617.0 110900.0 83487.0 100344.0 107517.0 80158.0 91720.0 True False 88269.6450460363 88870.55259206926 94233.23522802343 94686.97550012765 96967.75054142097 94986.57643047113 105010.19482786398 107829.85666960255 96191.83980165116 89071.80528282045 0.9909942294956621 0.997740556732715 1.057946843322805 1.0630409387064508 1.0886469655973554 1.0664045275479723 1.178938660718013 1.2105947143119151 1.0799358954971576 1.0 16.442681214037286 -5.739322791076007 0.801467552000796 1.1252630858497839 0.9777632980214473 0.3498704631506604 0.056172198796079015 0.9076564115334631 1.0207697025902198 0.026329946977628246 0.09469954980327919 1.8225405883489147e-06 5.739322791076007 -0.1474997878283365 GSS(ph)PLPTATTPKPLIPTEASIR ddPTM_A459_Selumetinib_30min_R1 1 GSSPLPTATTPKPLIPTEASIR 22 1 Q9BUK6-2;Q9BUK6;A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3 Q9BUK6-2 MSTO1 Protein misato homolog 1 1 GS(0.14)S(0.508)PLPT(0.349)AT(0.003)TPKPLIPTEASIR 98.015 9.5545e-05 20688000.0 1172.3 1647.0 1548.7 1492.2 1394.1 1132.0 1371.4 1411.4 1135.6 939.26 True False 1199.6123091012842 1454.168474330473 1338.3950464001666 1231.6152820631416 1268.0039011483464 1120.6131077737639 1267.9541938795264 1373.9650871266792 1927.030259057588 1059.8231701671632 1.1318985495590481 1.3720859434514068 1.26284750520133 1.1620950708870443 1.1964296845372302 1.0573585663323557 1.1963827830632683 1.2964097462692452 1.818256397200339 1.0 10.049607858125835 -8.009734564809868 24.543352133064907 1.4585298105087618 1.2028893808972616 0.1441104122907847 0.1999605993925927 511.6917529887043 1290098.6625449762 0.11130256607253543 0.0484745219858799 9.778346783110998e-09 8.009734564809868 -0.25564042961150024 GSS(ph)PLPTATTPKPLIPTEASIR ddPTM_A459_Selumetinib_30min_R2 2 GSSPLPTATTPKPLIPTEASIR 22 1 Q9BUK6-2;Q9BUK6;A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3 Q9BUK6-2 MSTO1 Protein misato homolog 1 1 GS(0.206)S(0.517)PLPT(0.256)AT(0.019)T(0.002)PKPLIPTEASIR;GS(0.207)S(0.707)PLPT(0.06)AT(0.024)T(0.003)PKPLIPTEASIR 66.36 0.003520900000000001 18718400.0 34051.0 32866.5 40903.0 44601.0 44865.0 25146.1 36354.1 37538.7 30327.4 39037.0 True False 32158.581736953067 35387.25486754593 38271.34551181914 38526.266858983545 39228.657601811086 28609.747021431696 38044.63768428255 37647.93140213367 36393.72741835625 37909.90037969331 0.8482897980438647 0.9334568150567167 1.009534320283243 1.0162587206275118 1.0347866179786687 0.7546774519290664 1.003554145572522 0.9930896949098825 0.9600058837888898 1.0 15.210287044923444 -4.832605964461766 3.4180425996511596 0.9686798057111905 0.8395936286997537 0.1952361977900927 0.07555249858363361 0.4770955945310624 9.207117366390571 0.01967926745235963 0.14902767300213696 1.4702596397676666e-05 4.832605964461766 -0.12908617701143676 GSS(ph)PQNTTTPK ddPTM_A459_Selumetinib_30min_R2 3 GSSPQNTTTPK 11 0 Q27J81-2;Q27J81 Q27J81-2 INF2 Inverted formin-2 1 GS(0.486)S(0.514)PQNTTTPK;GS(0.285)S(0.712)PQNT(0.001)T(0.001)TPK;GS(0.152)S(0.848)PQNTTTPK 141.34 0.0010117 9552100.0 124241.0 79422.0 104428.0 120104.0 119836.0 107536.0 134006.0 146822.0 122260.0 100557.0 True False 117336.18259612909 85513.41201801925 97709.21617260936 103745.6280090435 104781.13033256734 122348.107885385 140237.54452785154 147249.22771230954 146715.41622981962 97653.6581315371 1.2015543999189473 0.875680580269044 1.0005689294403843 1.0623834272475554 1.0729872524737343 1.252877877043634 1.4360705703308623 1.5078721118052578 1.5024057371429704 1.0 16.575386468406798 -6.882010519932419 2.275094033792288 1.4032455062464342 1.0242195968957462 0.4799877049703489 0.15533730495874745 0.22353023825796933 2.3595205629294203 0.06037925981983436 0.05154581504878396 1.312168113934096e-07 6.882010519932419 -0.37902590935068803 GSS(ph)PQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK ddPTM_A459_Selumetinib_30min_R2 1 GSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK 38 1 Q27J81-2;Q27J81 Q27J81-2 INF2 Inverted formin-2 1 GS(0.131)S(0.225)PQNT(0.19)T(0.19)T(0.19)PKPS(0.075)VEGQQPAAAAACEPVDHAQSESILK 61.555 4.8396e-05 105800000.0 75432.0 50325.0 66487.0 70726.0 64052.0 59562.0 55292.0 65820.0 53679.0 75003.0 True False 71239.79141822108 54184.76567962058 62209.29880557219 61092.99679084482 56005.21512785475 67766.12484999713 57863.187559019476 66011.5253029124 64416.29991657528 72837.46850880283 0.9780651754750556 0.7439133565312204 0.854083757702999 0.8387578267284423 0.7689066667807956 0.9303745206604372 0.7944151374786779 0.9062852767176349 0.8843841121247945 1.0 16.15239316137461 -8.795043357026623 0.7670049524254431 1.0005555821445358 0.83895999013437 0.3074897672272009 0.06801793228297023 1.1896355903271858 1.3831826743852564 0.06341780888086102 0.02258268977480947 1.6030853414923255e-09 8.795043357026623 -0.16159559201016582 GSS(ph)PTPPCS(ph)PVQPSK ddPTM_A459_Selumetinib_30min_R2 2 GSSPTPPCSPVQPSK 15 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 2 GS(0.094)S(0.852)PT(0.071)PPCS(0.982)PVQPSK;GS(0.111)S(0.826)PT(0.064)PPCS(1)PVQPSK 135.72 0.023109 0.0 37665.0 31961.1 36252.0 40477.0 40690.0 28658.2 32513.3 40634.0 32997.0 42494.0 True False 35571.73008494136 34412.41359886579 33919.58578819324 34963.962773280335 35578.15842678462 32605.606916762208 34025.23287388171 40752.23821267917 39597.3220132125 41267.08780732858 0.8619878933793873 0.833894888816325 0.8219524950866413 0.8472602412974516 0.8621436674401418 0.7901116519051246 0.824512576044661 0.9875239659010303 0.9595375907814957 1.0 15.33270401139653 -7.761913146894447 24.999999930002065 0.9801481208647094 0.8338828046268353 0.9054808594670823 0.021878928380551547 3.5644868947632395 188052.7979638269 0.011383944715222276 0.005993395228644791 1.730162334015814e-08 7.761913146894447 -0.1462653162378741 GSS(ph)PTPPCSPVQPSK ddPTM_A459_Selumetinib_30min_R1 4 GSSPTPPCSPVQPSK 15 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GS(0.002)S(0.995)PT(0.004)PPCSPVQPSK;GS(0.002)S(0.998)PTPPCSPVQPSK;GS(0.073)S(0.925)PT(0.002)PPCSPVQPSK;GS(0.017)S(0.982)PT(0.001)PPCSPVQPSK 268.5 8.076199999999998e-45 124301000.0 19359.699999999997 18766.8 24672.100000000002 23157.3 23518.1 19014.399999999998 20645.0 18883.699999999997 10914.5 16766.9 True False 19810.74334258136 16569.57433155138 21321.764334144464 19113.312271358245 21390.892007457784 18823.13239969386 19087.73102861515 18382.8429330977 18521.109336460064 18919.094938436443 1.0471295485881529 0.8758122090654703 1.1269970579209212 1.0102656778008565 1.1306509152295432 0.9949277415724774 1.0089135389788706 0.9716555148603182 0.9789638138995844 1.0 14.207555453477234 -10.389008380091102 7.972284109677424 0.999999999982219 1.0163285502699129 0.0046692068252486285 0.07067687344754672 0.0 0.0 0.06738849988902411 0.016344111819072197 4.083115075297458e-11 10.389008380091102 0.016328550287693866 GSS(ph)PTPPCSPVQPSK ddPTM_A459_Selumetinib_30min_R2 3 GSSPTPPCSPVQPSK 15 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GS(0.042)S(0.958)PTPPCSPVQPSK;GS(0.002)S(0.998)PTPPCSPVQPSK;GS(0.002)S(0.998)PTPPCSPVQPSK 271.41 5.201e-45 97407000.0 161912.0 140161.0 152224.0 160742.0 158900.0 126018.0 122437.0 129110.0 109048.0 108767.0 True False 152913.57922509025 150910.89801135252 142430.07356895987 138848.66230458365 138937.56141597626 143375.8356224934 128130.56310431278 129485.68872468885 130860.64705569591 105626.61409939524 1.4476804026038144 1.428720396824843 1.3484297947384014 1.3145234606680307 1.3153650961985321 1.3573836181814551 1.2130518827739871 1.2258812783948758 1.2388984364542377 1.0 16.688613862083947 -11.28323300111625 0.053936054645985915 4.234416212874088e-14 2.0510354986309705 0.9259704384034728 0.03332768148445963 58.283928725471675 0.46925325899300446 13.135683178394766 5.781905813693448 5.209151625866001e-12 11.28323300111625 2.0510354986309283 GSS(ph)QPNLSTSHSEQEYGK ddPTM_A459_Selumetinib_30min_R1 1 GSSQPNLSTSHSEQEYGK 18 0 I3L2B2;O95208-3;O95208-2;O95208;F6PQP6;E9PBC1 I3L2B2 EPN2 Epsin-2 1 GS(0.182)S(0.818)QPNLSTSHSEQEYGK 181.88 6.6965e-10 32163000.0 2555.4 2585.5 2582.9 3063.3 3730.9 2365.1 3483.1 2413.6 803.59 1578.0 True False 2614.9358480571714 2282.7884580336604 2232.1563668541285 2528.352160262713 3393.440753743894 2341.3092413389845 3220.3669627401023 2349.583487522285 1363.633538108565 1780.5516710216377 1.4686099205179393 1.2820680776558713 1.253631895767097 1.4199824702711408 1.905836718457499 1.3149347359268702 1.8086343772839422 1.3195817486016288 0.7658488996986788 1.0 10.798108587504327 -9.991254823069852 8.206874383436856 1.0000083280195358 1.4094722516619642 0.13439323651382684 0.29683371081532534 0.0 0.0 0.29201556996125044 0.07082417878089291 1.0203406213348591e-10 9.991254823069852 0.40946392364242845 GSS(ph)QPNLSTSHSEQEYGK ddPTM_A459_Selumetinib_30min_R2 2 GSSQPNLSTSHSEQEYGK 18 0 I3L2B2;O95208-3;O95208-2;O95208;F6PQP6;E9PBC1 I3L2B2 EPN2 Epsin-2 1 GS(0.206)S(0.783)QPNLS(0.002)T(0.007)S(0.002)HSEQEYGK;GS(0.032)S(0.664)QPNLS(0.12)T(0.061)S(0.112)HS(0.012)EQEYGK 109.77 0.0014248 10936000.0 21854.9 19152.7 27018.0 36884.0 36061.0 23634.1 23476.0 25628.0 22337.6 33331.0 True False 20640.292150096502 20621.65050436301 25279.6912949742 31860.335571551048 31530.694790569683 26889.482746001133 24567.680516811502 25702.573237056215 26805.744164691798 32368.647425661715 0.6376631027755881 0.6370871860408434 0.7809931308693664 0.9842961663666032 0.9741122134616071 0.8307261774763958 0.7589962037565511 0.7940576848657362 0.8281391499677039 1.0 14.982309461097158 -5.4081231605701054 3.641483860677565 0.8703148416608113 0.637812397012827 0.5945227248702596 0.07950130271867767 0.18196817107695248 4.305658828806726 0.023641594132600946 0.053638952224676247 3.907300738391381e-06 5.4081231605701054 -0.2325024446479843 GSS(ph)SGSCSQECGEELR ddPTM_A459_Selumetinib_30min_R2 1 GSSSGSCSQECGEELR 16 0 J3KQ40;O95759-2;O95759 J3KQ40 TBC1D8 TBC1 domain family member 8 1 GSS(0.602)S(0.035)GS(0.363)CS(0.001)QECGEELR 231.21 2.4074999999999998e-15 2392000.0 4592.6 5664.2 4884.9 6494.4 7941.1 5227.8 4983.1 4560.7 4748.1 6686.7 True False 4337.361677634452 6098.625926726417 4570.61085227698 5609.851516535113 6943.468023665262 5947.881996756586 5214.82402382533 4573.970881935473 5697.852672998588 6493.637596866947 0.6679402126979096 0.9391694309625293 0.7038598603781354 0.8638996914828995 1.0692724871211399 0.9159553344378693 0.8030666858189592 0.7043772944985911 0.8774515959664411 1.0 12.6648111562291 -4.747737366945827 24.90657159682511 0.8653621367525839 0.6679396997560166 0.23397280572803736 0.11123943114462437 1134.482864509531 2062059.7114220585 0.02901424998214668 0.5726216142526313 1.7875682530650796e-05 4.747737366945827 -0.19742243699656725 GSS(ph)SQGPSQTSTPTDVTAIHL ddPTM_A459_Selumetinib_30min_R2 1 GSSSQGPSQTSTPTDVTAIHL 21 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 GS(0.142)S(0.716)S(0.142)QGPSQTSTPTDVTAIHL 163.11 4.4988e-08 7141500.0 8948.2 6989.3 10824.0 9972.0 10351.0 10482.0 8430.6 6302.4 6180.4 7397.3 True False 8450.894866482735 7525.35683585836 10127.595624280128 8613.796397340504 9050.614840885912 11925.800353877827 8822.639604916982 6320.738940581514 7416.652694804331 7183.720728506425 1.1763952394401849 1.0475569861723961 1.4097980708091595 1.1990717238156623 1.2598784366674056 1.6601146960730102 1.2281434563438696 0.8798698027749842 1.0324249751766639 1.0 12.810515550187931 -7.663044644883631 5.853568915338782 0.9692537628930284 1.2929535167990978 0.45678982133969614 0.15692299455024944 0.19518228903206464 9.634527836806686 0.07999432165465026 0.04518674243014824 2.1724778396094496e-08 7.663044644883631 0.3236997539060693 GSS(ph)TPTKGIENK ddPTM_A459_Selumetinib_30min_R2 1 GSSTPTKGIENK 12 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;H0YBE9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 GS(0.005)S(0.952)T(0.043)PTKGIENK 135.94 0.0068767 2689200.0 13927.0 34987.0 22758.0 30790.0 20924.0 8358.7 4263.5 2982.2 3253.8 21979.0 True False 13152.993094198284 37670.39039906377 21293.775057036895 26596.348884287407 18295.340057066634 9510.035052276153 4461.761197964978 2990.8777082702136 3904.6509187680954 21344.409161699892 0.6162266190904844 1.7648832588282175 0.997627757963249 1.2460569267952153 0.8571490509981197 0.44555157185333694 0.20903652868363767 0.14012464273956116 0.18293553544571972 1.0 14.381570607195524 -6.641890093149474 2.2324304134932746 0.31049482502254433 1.1900594401235784 0.5065420862132259 0.35178964693791925 0.21680696225134222 2.206237889192266 0.12445161940400751 0.12394899934083822 2.2809192309126808e-07 6.641890093149474 0.8795646151010341 GSSAAASPGS(ph)PPPGR ddPTM_A459_Selumetinib_30min_R1 4 GSSAAASPGSPPPGR 15 0 Q86UX6 Q86UX6 STK32C Serine/threonine-protein kinase 32C 1 GSSAAAS(0.001)PGS(0.999)PPPGR;GSSAAASPGS(1)PPPGR;GSSAAASPGS(1)PPPGR;GSSAAASPGS(1)PPPGR 190.18 2.7123e-05 87776000.0 7155.900000000001 9214.900000000001 8872.9 9824.1 9652.5 7795.9 8569.0 7941.6 4350.41 6668.6 True False 7322.618547042465 8136.015224109219 7668.008915350959 8108.505356196559 8779.43307928729 7717.48032411085 7922.633431058525 7730.962970047643 7382.328028625148 7524.579767664701 0.9731598006987551 1.0812584191175743 1.0190614163335228 1.0776024185484956 1.1667672282530723 1.025636057082563 1.052900451013142 1.027427870891851 0.98109505867014 1.0 12.87739529722742 -7.944223851724453 1.9457190401692546 0.9900985548576493 1.061300781904438 0.22876795879300327 0.047852011594094676 0.5210843555483375 3.6549648062291964 0.040093173310079756 0.013977738802663875 1.1370410609898944e-08 7.944223851724453 0.07120222704678869 GSSAAASPGS(ph)PPPGR ddPTM_A459_Selumetinib_30min_R2 5 GSSAAASPGSPPPGR 15 0 Q86UX6 Q86UX6 STK32C Serine/threonine-protein kinase 32C 1 GSSAAAS(0.03)PGS(0.97)PPPGR;GSSAAAS(0.094)PGS(0.906)PPPGR;GSSAAAS(0.001)PGS(0.999)PPPGR;GSSAAAS(0.06)PGS(0.94)PPPGR;GSSAAAS(0.41)PGS(0.589)PPPGR 180.56 1.9229e-05 73721000.0 49416.799999999996 42473.3 57227.799999999996 51671.2 62608.5 42974.200000000004 42536.700000000004 51338.4 42348.49999999999 50435.7 True False 46670.41208712409 45730.86553681528 53545.82565291747 44633.49342220824 54743.06050290846 48893.50596905327 44514.74083487201 51487.78624447033 50819.38331595386 48979.49029331396 0.9528562222195057 0.9336737737154007 1.093229540206686 0.9112690465931823 1.1176731357365977 0.9982444830735115 0.9088445095752371 1.0512111485059445 1.0375645604235915 1.0 15.57989014007579 GSSDAVSPDTFTAEVSSDAVPDVRS(ph)PATPACR ddPTM_A459_Selumetinib_30min_R1 1 GSSDAVSPDTFTAEVSSDAVPDVRSPATPACR 32 1 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 GSSDAVSPDT(0.001)FT(0.001)AEVS(0.02)S(0.018)DAVPDVRS(0.697)PAT(0.262)PACR 44.726000000000006 0.012946 10030000.0 1083.1 1388.0 1617.4 1494.9 2025.3 1291.4 1449.8 949.98 660.15 627.92 True False 1108.3341226542705 1225.4923147363058 1397.7659637422544 1233.8437777484191 1842.1119725957565 1278.4096884973837 1340.440418759323 924.7834444300721 1120.2263345516612 708.5196484587494 1.5642955351559296 1.7296518415574398 1.9727977435528148 1.7414390418563734 2.599944795607183 1.8043390769448981 1.8918888441205515 1.3052333078437044 1.5810801252844602 1.0 9.468664051867833 -8.140343600484856 1.1075864919469076 1.0890118965003304 1.9234207130966086 0.47323367263733374 0.29116500787264193 0.4230555236511166 0.9935066102844115 0.2769326447065744 0.09467029474405138 7.238630352143524e-09 8.140343600484856 0.8344088165962782 GSSDGRGS(ph)DSESDLPHR ddPTM_A459_Selumetinib_30min_R1 1 GSSDGRGSDSESDLPHR 17 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 GSSDGRGS(0.509)DS(0.322)ES(0.169)DLPHR 90.758 0.0048431 30598000.0 1616.0 1514.8 1677.0 1952.9 1770.4 1324.4 1797.7 1579.2 725.27 1374.5 True False 1653.6496558113763 1337.4465117885861 1449.2726111016198 1611.8626754731995 1610.2676325895065 1311.0777384589862 1662.0980416634259 1537.3144860354637 1230.730218375041 1550.930463763779 1.0662306882529857 0.8623510486362408 0.9344536360350694 1.0392875200616996 1.03825907750998 0.8453491430410612 1.071677989759687 0.9912207684055208 0.7935431324163431 1.0 10.598918289003823 -10.034012557251692 5.337189230698011 0.9999999875733429 0.9620505360046121 0.01553888309484519 0.09392093252593907 122651709.34366387 392794608.06750536 1.1850416104097037 0.022768238501892298 9.246714374717821e-11 10.034012557251692 -0.03794945156873075 GSSDGRGS(ph)DSESDLPHR ddPTM_A459_Selumetinib_30min_R2 2 GSSDGRGSDSESDLPHR 17 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 GSSDGRGS(0.997)DS(0.003)ESDLPHR;GS(0.012)S(0.012)DGRGS(0.924)DS(0.05)ES(0.001)DLPHR 104.35 0.0015482 21250000.0 97137.0 81306.0 100892.0 124264.0 120672.0 89567.0 84604.0 85445.0 85300.0 104361.0 True False 91738.51441022029 87541.90876000455 94400.71856290387 107339.02883264353 105512.10453863231 101904.04124172626 88538.25363964548 85693.63080381886 102362.38348113553 101347.82676755822 0.9051848207916985 0.8637768717111456 0.9314528152578192 1.059115249494458 1.0410889695802248 1.005488173667934 0.8736078164034877 0.8455398950029551 1.010010641036282 1.0 16.628955627422364 -5.5213975285289765 24.998319208167896 0.9715709677483653 0.8877643308048104 0.24198546607814453 0.06503263107373605 88.75582503384834 1497919.2004198632 0.019942859247752322 0.03519043263178689 3.0102493512583696e-06 5.5213975285289765 -0.08380663694355484 GSSEQAES(ph)DNMDVPPEDDSKEGAGEQK ddPTM_A459_Selumetinib_30min_R1 1 GSSEQAESDNMDVPPEDDSKEGAGEQK 27 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3;K7EKJ9;K7EM82;K7EJ09;K7ER69 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 GS(0.001)S(0.002)EQAES(0.995)DNMDVPPEDDS(0.002)KEGAGEQK 100.69 6.0897e-07 8193600.0 788.98 833.65 536.29 540.44 767.52 865.65 844.01 789.6 456.58 829.19 True False 807.3616989121649 736.0458704466295 463.464763630106 446.06229931524206 698.0979515166619 856.9423469473135 780.345646183651 768.6572430177318 774.7829127161973 935.6246134945706 0.8629119919116472 0.7866892980695411 0.4953533254101331 0.47675348946752627 0.7461303833267667 0.9159040223905849 0.8340371073277448 0.8215444868928647 0.8280916315597692 1.0 9.869786004970274 -6.5417695046063065 6.5491893284576195 0.8631761409309829 0.6481165151742858 0.43701758721127193 0.11976291981281639 0.17283765666642403 29.334305243659482 0.042831653872645675 0.04377827272994846 2.872304610888334e-07 6.5417695046063065 -0.21505962575669713 GSSGCSEAGGAGHEEGRAS(ph)PLRR ddPTM_A459_Selumetinib_30min_R1 2 GSSGCSEAGGAGHEEGRASPLRR 23 2 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 GSSGCSEAGGAGHEEGRAS(1)PLRR;GSSGCSEAGGAGHEEGRAS(1)PLRR 70.414 0.0009534 13232400.0 2642.3999999999996 3165.6 2711.1 2819.3 3309.2 2845.7 3574.3999999999996 2890.3 1013.56 1753.2599999999998 True False 2703.9627787846384 2794.9700803524856 2342.9475110063217 2326.9621798154503 3009.883444286714 2817.0748416888678 3304.780130234051 2813.639854982459 1719.9372925065234 1978.3079991986033 1.3668057652701158 1.4128083602172694 1.1843188785342984 1.1762385739521268 1.5214432967495424 1.423981929421527 1.67050839989162 1.4222456038808122 0.869398138815218 1.0 10.950051338830237 -8.258387991156994 24.996234870797533 0.9346990332466829 1.3974784053727827 0.636759618172344 0.13975579923653986 171.54798277840607 1405310.784598092 0.11488457542559748 0.039165783647760764 5.515844431225674e-09 8.258387991156994 0.46277937212609976 GSSGCSEAGGAGHEEGRAS(ph)PLRR ddPTM_A459_Selumetinib_30min_R2 1 GSSGCSEAGGAGHEEGRASPLRR 23 2 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 GSSGCSEAGGAGHEEGRAS(1)PLRR 70.907 0.00087881 12270000.0 17540.0 15574.0 23125.0 29695.0 31466.0 27343.0 20753.0 22004.0 22342.0 28121.0 True False 16565.19701818323 16768.475721697192 21637.162676596283 25650.489773267756 27512.959770390895 31109.25005495909 21718.05562128936 22068.027997041714 26811.024287638094 27309.07366286739 0.6065821646930195 0.6140257970191634 0.7923067235347752 0.939266197379121 1.0074658741647737 1.1391543499060117 0.7952688505439776 0.8080840921033504 0.9817624947159411 1.0 14.737092757561356 -5.479559111573042 2.301304469109016 0.9494270708517696 0.6022353957514297 0.6838264868057867 0.09339314771094338 0.19493751855273772 2.0119622036811906 0.029353740316892897 0.07436534844060043 3.3146745089657667e-06 5.479559111573042 -0.3471916751003399 GSSGHT(ph)PPPSGPPNMAVGNMSVLLR ddPTM_A459_Selumetinib_30min_R2 1 GSSGHTPPPSGPPNMAVGNMSVLLR 25 0 P08151-3;P08151-2;P08151 P08151-3 GLI1 Zinc finger protein GLI1 1 GS(0.048)S(0.048)GHT(0.904)PPPSGPPNMAVGNMSVLLR 75.539 0.00041155 2849800.0 18774.0 15671.0 20300.0 20975.0 25207.0 13051.0 16122.0 15316.0 15912.0 22585.0 True False 17730.616238276616 16872.91530979302 18993.920100968848 18118.168816106798 22040.271306560837 14848.65678481774 16871.70494513694 15360.56702429971 19094.84461842705 21932.91236712282 0.8084022742394487 0.7692966181310844 0.866000820275948 0.8260721837956059 1.0048948784202023 0.6770034246375645 0.7692414332730125 0.7003432452192269 0.8706023303612885 1.0 14.420809772894012 -6.795437173759483 24.999985317196604 0.7825724018005834 0.8491878357055929 0.038798405123616986 0.1030611758196818 480.1903419851985 353100.42228584545 0.0351492107061584 0.031000343762512098 1.6016323281471139e-07 6.795437173759483 0.06661543390500946 GSSGPQPAKPCSGATPTPLLLVGDRS(ph)PVPS(ph)PGSSSPQLQVK ddPTM_A459_Selumetinib_30min_R1 1 GSSGPQPAKPCSGATPTPLLLVGDRSPVPSPGSSSPQLQVK 41 2 Q8N3F8 Q8N3F8 MICALL1 MICAL-like protein 1 2 GSSGPQPAKPCS(0.004)GAT(0.005)PT(0.037)PLLLVGDRS(0.37)PVPS(0.377)PGS(0.402)S(0.402)S(0.402)PQLQVK 43.38399999999999 0.032451999999999995 8908100.0 621.9 628.51 719.69 935.19 911.84 516.39 682.12 650.4 471.67 522.85 True False 636.3890599932516 554.9237570136283 621.9600509741944 771.8766221904767 829.3642329984277 511.195585444606 630.6671392220377 633.1492792030555 800.3895405862031 589.9628904902808 1.0786933725007501 0.940607902562255 1.0542358866967425 1.3083477531087064 1.4057905105000683 0.8664876955562133 1.0689945916732664 1.0732018732176276 1.356677773276638 1.0 9.204480399521398 -5.535948723471821 24.704808405428967 1.1544445885606338 1.0065934057469552 0.12434200431530351 0.16061945501756747 395.7048777436462 747956.792736253 0.04535282819579233 0.07861458853246311 2.9110608025614455e-06 5.535948723471821 -0.1478511828136786 GSSGS(ph)PAHAESYSSGGGGQQK ddPTM_A459_Selumetinib_30min_R1 3 GSSGSPAHAESYSSGGGGQQK 21 0 P15408 P15408 FOSL2 Fos-related antigen 2 1 GS(0.053)S(0.224)GS(0.723)PAHAESYSSGGGGQQK;GS(0.002)S(0.028)GS(0.971)PAHAESYSSGGGGQQK;GS(0.05)S(0.227)GS(0.723)PAHAESYSSGGGGQQK 222.11 1.0982e-20 31636400.0 7665.64 7827.379999999999 7213.64 8178.68 11254.09 7129.75 7989.74 7073.45 1727.7 5035.84 True False 7844.234497261087 6910.946710749759 6234.067309688185 6750.427070837807 10236.15954657097 7058.03118829505 7387.067479223423 6885.839128196264 2931.780713784604 5682.2391172354955 1.3804829989409948 1.216236516655436 1.0971145671745617 1.1879871528746933 1.8014306218691891 1.2421214670263472 1.3000275642777517 1.2118179094769141 0.5159551812756102 1.0 12.472243828261213 -8.120515168818672 5.525986606410367 0.765334058469814 1.3122537080525554 0.5255097996875331 0.20948931668932794 0.17886484163604546 7.206656601743277 0.1493538304131903 0.054593893671484685 7.576782685991912e-09 8.120515168818672 0.5469196495827414 GSSGS(ph)PAHAESYSSGGGGQQK ddPTM_A459_Selumetinib_30min_R2 2 GSSGSPAHAESYSSGGGGQQK 21 0 P15408 P15408 FOSL2 Fos-related antigen 2 1 GSS(0.002)GS(0.998)PAHAESYSSGGGGQQK;GS(0.002)S(0.08)GS(0.918)PAHAESYSSGGGGQQK 329.79 7.752099999999994e-156 5265200.0 9295.3 10007.2 14641.3 18724.2 24301.0 13539.2 11336.2 13798.2 10294.6 17119.6 True False 8778.704438034129 10774.72006178041 13699.294698242113 16173.931658953372 21248.091126303592 15404.101903379384 11863.355762254147 13838.350477585023 12353.807655157061 16625.312665937377 0.528032441520351 0.6480912737272062 0.8240022292218172 0.9728497733514021 1.278056632873892 0.9265450949948111 0.7135718888800375 0.8323663293224917 0.7430721998069876 1.0 14.021093852635795 -5.23766263364199 2.295682674218159 0.9214699986182429 0.5439329258018307 0.44818171752902103 0.1489464464919258 0.34235418329083733 3.347169122404683 0.046278237236088 0.17182279751825727 5.7854529540907386e-06 5.23766263364199 -0.37753707281641213 GSSGS(ph)VDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R2 1 GSSGSVDETLFALPAASEPVIR 22 0 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 GS(0.04)S(0.225)GS(0.735)VDETLFALPAASEPVIR 113.05 3.9165e-05 1598800.0 4564.0 1038.8 4061.1 3813.8 2563.8 2674.3 3438.0 3025.0 2589.8 1208.9 True False 4310.351151139578 1118.4726197315417 3799.8132473913556 3294.353860828038 2241.7125233371926 3042.6605501216827 3597.873812267761 3033.802249184293 3107.8323650579673 1173.9959159005873 3.671521419078407 0.9527057160787029 3.236649460127355 2.8061033400622155 1.9094721650863207 2.5917130621256197 3.06463912142981 2.584167634737489 2.647225874439188 1.0 10.1972116742683 GSSHS(ph)PDHPGCLMEN ddPTM_A459_Selumetinib_30min_R1 1 GSSHSPDHPGCLMEN 15 0 O95149 O95149 SNUPN Snurportin-1 1 GS(0.001)S(0.003)HS(0.996)PDHPGCLMEN 118.52 0.0020152 5999400.0 1389.3 1754.8 1613.1 1680.0 2176.9 1521.0 1804.5 1508.9 468.15 1043.7 True False 1421.6679868927877 1549.3472002156127 1394.0498801240446 1386.619537505749 1979.999779362912 1505.700120957505 1668.3851121887144 1468.8790704020464 794.4163576768311 1177.6690614989132 1.2071880236739154 1.31560491046919 1.183736523017533 1.177427159155296 1.6812870814851915 1.2785426485103384 1.416684165978877 1.2472766063264726 0.6745667213722285 1.0 10.201718466944554 -8.153812662034788 5.50827939505941 0.8429299609105931 1.3237360815604968 0.5960352548071511 0.15748334366173397 0.14581270228598617 6.068755372093348 0.11122850147813403 0.04038554893067804 7.017579445743417e-09 8.153812662034788 0.4808061206499037 GSSHS(ph)PDHPGCLMEN ddPTM_A459_Selumetinib_30min_R2 2 GSSHSPDHPGCLMEN 15 0 O95149 O95149 SNUPN Snurportin-1 1 GSSHS(1)PDHPGCLMEN;GSS(0.001)HS(0.999)PDHPGCLMEN 120.9 0.0017382 11849400.0 42646.0 36458.0 54177.0 64356.0 66646.0 49807.0 45707.0 48963.0 55028.0 63753.0 True False 40275.906045464195 39254.21136905331 50691.31080345759 55590.60177970774 58273.333657200434 56667.46214707045 47832.466066702305 49105.47422373902 66035.13761078459 61912.28523981316 0.6505317303255425 0.6340294372434276 0.8187601314845372 0.8978929071085198 0.9412240790576946 0.9152862299876797 0.7725844052020758 0.7931458842704997 1.066591829957525 1.0 15.917938091024016 -5.3961439859988705 2.7245314945982546 0.8988350016710147 0.6364710849160647 0.6225870750877156 0.08263089883482554 0.18931745341203274 2.676391743570446 0.023290746755908986 0.05976042648621981 4.016576231973833e-06 5.3961439859988705 -0.26236391675494997 GSSLSSESSPVSSPATNHS(ph)SPASTPK ddPTM_A459_Selumetinib_30min_R1 1 GSSLSSESSPVSSPATNHSSPASTPK 26 0 Q14687-3;Q14687 Q14687-3 GSE1 Genetic suppressor element 1 1 GSSLSSESSPVSSPAT(0.063)NHS(0.528)S(0.342)PAS(0.033)T(0.033)PK 109.46 1.547e-08 5416700.0 1197.8 1011.0 1235.8 1140.4 1664.4 1271.5 1220.7 1272.2 535.05 923.02 True False 1225.706409486922 892.6316499988513 1067.985147763495 941.250547959259 1513.8553138736875 1258.7098644296304 1128.6216162087924 1238.4571233120034 907.9407714941545 1041.498607976168 1.1768680246905996 0.8570646596767002 1.0254311811695989 0.9037463331691723 1.4535356094382108 1.208556453930885 1.083651583943949 1.1891106851487432 0.8717637878157687 1.0 10.024445195795595 -4.456254027900159 22.430983885076017 1.0787219157295165 4.241409540041936 0.03089751424396725 0.17354232831524752 2012.8807708178563 719109.0805183871 0.04334023938084939 19471.446415397488 3.497405366537884e-05 4.456254027900159 3.162687624312419 GSSLSSESSPVSSPATNHS(ph)SPASTPK ddPTM_A459_Selumetinib_30min_R2 1 GSSLSSESSPVSSPATNHSSPASTPK 26 0 Q14687-3;Q14687 Q14687-3 GSE1 Genetic suppressor element 1 1 GSSLSSESSPVSSPAT(0.003)NHS(0.343)S(0.343)PAS(0.121)T(0.19)PK 110.13 1.4139e-08 4400400.0 12807.0 7229.6 12086.0 14622.0 17230.0 11308.0 10025.0 11425.0 8210.6 11752.0 True False 12095.238210483041 7784.087073172082 11308.39991824184 12630.45837564309 15065.41336184563 12865.574356196379 10491.182364160642 11458.244858489426 9852.9494233319 11412.689224637028 1.0598061484380532 0.6820554665037458 0.9908619866586698 1.1067030852270308 1.3200581445189379 1.127304362973711 0.9192559402662878 1.0039916651505814 0.8633328420143033 1.0 13.478351160125413 -4.3906606667537 22.120525624514983 1.0073743603303156 45.1535347099785 0.010595657461831998 0.1602199207304888 6913.8997545518 1154348.9740457295 0.04242929156602455 31841.16462889155 4.067610251882201e-05 4.3906606667537 44.146160349648184 GSSLSSESSPVSSPATNHSS(ph)PASTPK ddPTM_A459_Selumetinib_30min_R1 1 GSSLSSESSPVSSPATNHSSPASTPK 26 0 Q14687-3;Q14687 Q14687-3 GSE1 Genetic suppressor element 1 1 GSSLSSESSPVSSPATNHS(0.128)S(0.437)PAS(0.217)T(0.217)PK 109.59 1.5219999999999997e-08 3536100.0 1154.5 1252.0 1399.0 1440.8 1215.2 1827.8 1246.9 1437.4 650.26 797.66 True False 1181.3976037340553 1105.4152579609909 1209.023484156927 1189.1913271656438 1105.285374560985 1809.4139915096166 1152.845329115051 1399.2754826667779 1103.4437268886822 900.0474308663619 1.312594829137919 1.2281744495364508 1.3432886342369235 1.3212540654895928 1.2280301422526883 2.0103540429729603 1.280871751397982 1.5546686037644397 1.2259839748962302 1.0 9.813857220631071 GSSLSSESSPVSSPATNHSSPAS(ph)TPK ddPTM_A459_Selumetinib_30min_R2 1 GSSLSSESSPVSSPATNHSSPASTPK 26 0 Q14687-3;Q14687 Q14687-3 GSE1 Genetic suppressor element 1 1 GSSLSSESSPVSSPATNHS(0.056)S(0.163)PAS(0.39)T(0.39)PK 122.21 5.0917000000000005e-09 3411500.0 16125.0 10734.0 16486.0 22230.0 22127.0 16777.0 12406.0 15296.0 13778.0 18679.0 True False 15228.837053489424 11557.263284750068 15425.308708599618 19202.23565111104 19347.208442110194 19087.87946355735 12982.903582022629 15340.508827610875 16533.984989485158 18139.688736129603 0.839531332373829 0.6371257772318313 0.8503623702140138 1.058575807470451 1.0665678294454701 1.0522716095750417 0.7157181013896903 0.845687544630053 0.911481185261669 1.0 14.146862080030274 -5.519867365925201 24.34049496693468 0.9438496116331913 0.7396824036853102 0.36282937594730114 0.11240338933066914 94.35959487674673 762691.1752336886 0.033321136011336544 0.05922605016219396 3.0208741582622675e-06 5.519867365925201 -0.204167207947881 GSSMGVRNS(ph)PQALR ddPTM_A459_Selumetinib_30min_R1 2 GSSMGVRNSPQALR 14 1 Q7L7X3;Q7L7X3-3 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 GSSMGVRNS(1)PQALR;GSSMGVRNS(1)PQALR 93.738 0.0077298 36459000.0 4328.3 2953.3999999999996 6982.200000000001 7158.3 5640.8 4495.8 3965.0 3721.1000000000004 2551.3999999999996 2418.0 True False 4429.140968594294 2607.61455500159 6034.055590479269 5908.237282932974 5130.590635964128 4450.5763338597935 3665.9168577601868 3622.404340163732 4329.53945311688 2728.3738533145256 1.6233629285127533 0.9557394606438436 2.2115941270837514 2.165479366310243 1.8804573389864823 1.631219390426673 1.343627030183822 1.327678879403974 1.5868571119229873 1.0 11.413825626739992 -7.144198365800013 3.3523796903661793 1.3395451341480638 1.7683421286169259 0.2704390619599465 0.35026280624526596 0.41455121258007055 8.681334717079427 0.1561983036042378 0.11716308645123259 7.174665106246935e-08 7.144198365800013 0.4287969944688621 GSSMGVRNS(ph)PQALR ddPTM_A459_Selumetinib_30min_R2 1 GSSMGVRNSPQALR 14 1 Q7L7X3;Q7L7X3-3 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 GSS(0.001)MGVRNS(0.999)PQALR 64.565 0.040998 4382300.0 15549.0 21102.0 22893.0 25380.0 23013.0 13167.0 9360.2 8910.9 10572.0 17359.0 True False 14684.84882757873 22720.455546375615 21420.089304013778 21923.200217057947 20121.90120116969 14980.634731874577 9795.46784688443 8936.82924372109 12686.695406360663 16857.800565901463 0.8711011125189132 1.3477710486344603 1.2706336879640472 1.3004780861746785 1.1936255339187352 0.8886470493770191 0.5810644044928303 0.5301302034500132 0.7525712121676323 1.0 14.041128699954271 -6.905049482007797 3.042237352083169 0.6795095858721649 1.217753250168847 0.6391346371197328 0.1700704782678474 0.14608510134465674 2.71730838529141 0.06377397786677787 0.05479622237772705 1.2443728241681457e-07 6.905049482007797 0.5382436642966821 GSSPQNT(ph)TTPKPSVEGQQPAAAAACEPVDHAQSESILK ddPTM_A459_Selumetinib_30min_R1 3 GSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILK 38 1 Q27J81-2;Q27J81 Q27J81-2 INF2 Inverted formin-2 1 GS(0.031)S(0.063)PQNT(0.296)T(0.296)T(0.296)PKPS(0.018)VEGQQPAAAAACEPVDHAQSESILK;GS(0.04)S(0.151)PQNT(0.248)T(0.248)T(0.248)PKPS(0.065)VEGQQPAAAAACEPVDHAQSESILK;GS(0.02)S(0.072)PQNT(0.303)T(0.303)T(0.303)PKPSVEGQQPAAAAACEPVDHAQSESILK 121.52 8.8134e-24 79721000.0 5917.110000000001 5808.84 10339.650000000001 10379.96 7772.72 5670.669999999999 6415.42 6376.32 2910.5699999999997 4021.75 True False 6054.967150308198 5128.738312343551 8935.582321632002 8567.294841981047 7069.6788483851715 5613.628208356405 5931.4997043157255 6207.199280393649 4939.024710377987 4537.980787662403 1.3342866428104079 1.130180702017793 1.9690657011870878 1.8879090156735145 1.557890872435115 1.2370321671740898 1.307079069272823 1.3678328690305213 1.0883749714864195 1.0 12.147834785782772 -6.748015317588975 5.444819304377783 1.2279297621001672 1.5928150103673904 0.36491444226620673 0.2463806345838944 0.2277195678978861 20.22856176864042 0.09276093433091695 0.08836140346408206 1.7864245664534872e-07 6.748015317588975 0.36488524826722313 GSSPS(ph)HSATSVHTSV ddPTM_A459_Selumetinib_30min_R1 1 GSSPSHSATSVHTSV 15 0 F8WA39;Q13613 F8WA39 MTMR1 Myotubularin-related protein 1 1 GS(0.065)S(0.047)PS(0.388)HS(0.132)AT(0.205)S(0.164)VHTSV 76.24 0.037154 1746700.0 644.66 827.42 723.36 734.63 1055.3 649.64 1042.7 691.21 144.34 369.11 True False 659.6793237100011 730.5452817428777 625.1316851320621 606.3406612130048 959.8483013283476 643.105211425926 964.048299517414 672.8768654334937 244.93443782350496 416.48886393586645 1.5839062717690877 1.7540571789582629 1.5009565423298419 1.455838831999054 2.3046193654679588 1.5441114207676758 2.314703664359833 1.6155938938552448 0.588093605934255 1.0 8.702134111153581 -8.179726237432847 5.345183288163343 0.8005521794182556 1.777514050646524 0.6166121667902149 0.3057137168977416 0.13177609504888477 6.257566448021812 0.21594700011663234 0.07732223437350808 6.611100550834097e-09 8.179726237432847 0.9769618712282683 GSSPSIRPIQGSQGS(ph)SSPVEK ddPTM_A459_Selumetinib_30min_R1 1 GSSPSIRPIQGSQGSSSPVEK 21 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 GSSPSIRPIQGS(0.005)QGS(0.528)S(0.128)S(0.339)PVEK 91.733 0.0056789 0.0 1088.6 1492.5 1210.0 1372.6 1246.2 935.25 1391.1 1447.8 561.04 1204.4 True False 1113.9622619531337 1317.7574061555742 1045.6886460542391 1132.9011768930889 1133.48143003448 925.8422341390575 1286.1682070189645 1409.3996408828164 952.043903259659 1358.9964718494684 0.8196947416921062 0.9696547661836299 0.7694564833057688 0.8336306976215436 0.8340576694006545 0.6812690491234844 0.9464102620285751 1.0370885208883243 0.7005492089056091 1.0 10.408325995328184 -10.846720830285857 5.94285336331295 1.0000145302489658 0.8484412248823863 0.15694853079734794 0.10825351262010259 2.075889818247667e-05 2.3617823631934188e-06 0.10440431788485183 0.02531934002487315 1.4232433710879953e-11 10.846720830285857 -0.15157330536657954 GSSPSIRPIQGSQGS(ph)SSPVEK ddPTM_A459_Selumetinib_30min_R2 1 GSSPSIRPIQGSQGSSSPVEK 21 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 GSSPSIRPIQGS(0.069)QGS(0.597)S(0.167)S(0.167)PVEK 69.771 0.003682 22156000.0 24499.0 22918.0 23117.0 24006.0 27606.0 21558.0 26958.0 23498.0 18803.0 22965.0 True False 23137.44365726745 24675.7369070153 21629.677387886524 20736.34138734016 24137.887479228702 24527.418815960526 28211.600416263598 23566.375289696694 22564.12539971617 22301.940779764227 1.0374632363054843 1.1064389933904295 0.9698562829792964 0.9297998587708285 1.0823222838583775 1.0997885367095763 1.264984096893555 1.0566961648055204 1.0117561347033006 1.0 14.444881642677439 -6.497790495775926 23.292197521603708 1.1001925712330691 1.0136932570013655 0.1620726732171891 0.08064395096642149 548.4373829071121 509175.1387142892 0.026505504714679693 0.02988836630585734 3.1784069685480265e-07 6.497790495775926 -0.08649931423170365 GSSPSIRPIQGSQGSSS(ph)PVEK ddPTM_A459_Selumetinib_30min_R1 1 GSSPSIRPIQGSQGSSSPVEK 21 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 GSSPSIRPIQGSQGS(0.013)S(0.055)S(0.932)PVEK 151.85 7.2685e-07 7601500.0 2133.6 2799.7 1859.1 2188.5 2098.5 2061.8 2819.6 2196.0 1206.3 2377.4 True False 2183.3087287370977 2471.9098224547815 1606.6444313053191 1806.3195582329345 1908.6910455202674 2041.0601639646172 2606.9153019270157 2137.754946386701 2047.002995333893 2682.562447837035 0.8138892462680641 0.9214733563604068 0.5989215395901651 0.6733560143919035 0.711517842598317 0.7608621247980025 0.9718004156917152 0.7969078028772022 0.763077481004926 1.0 11.389396040783176 -7.035418024192057 20.552726243859915 0.8660666463515926 0.7411802204956975 0.287744153923319 0.1039313312576154 111.05292945271769 64441.57923930351 0.04160000257127509 0.03226114799538817 9.216838459246541e-08 7.035418024192057 -0.12488642585589504 GSSPSIRPIQGSQGSSS(ph)PVEK ddPTM_A459_Selumetinib_30min_R2 1 GSSPSIRPIQGSQGSSSPVEK 21 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 GSSPSIRPIQGSQGS(0.185)S(0.185)S(0.631)PVEK 132.87 2.4781e-05 20401000.0 31686.0 22963.0 30544.0 32491.0 29084.0 22571.0 27718.0 29036.0 22670.0 24294.0 True False 29925.01896910795 24724.188262317468 28578.832293792715 28065.669749898738 25430.207905741066 25679.950370862072 29006.94192217503 29120.489952831427 27204.633452723803 23592.569096607534 1.2684086606494662 1.0479650673513405 1.21134888603133 1.1895978617239447 1.077890576545891 1.0884762174779299 1.2294948381160424 1.2343077107706246 1.1531017813840232 1.0 14.526044907966746 GSSPT(ph)PPCS(ph)PVQPSK ddPTM_A459_Selumetinib_30min_R1 1 GSSPTPPCSPVQPSK 15 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 2 GSS(0.001)PT(0.999)PPCS(1)PVQPSK 154.81 0.0027218000000000003 0.0 1921.3 1915.5 1971.8 2113.5 2079.2 1711.2 2164.7 1655.7 936.75 1527.0 True False 1966.0625518009863 1691.2323695082086 1704.0403903221077 1744.4169003085697 1891.1367271125748 1693.9868816452865 2001.4149361900306 1611.7854575284434 1589.596332486963 1723.00532423957 1.1410658598334205 0.9815595725188 0.9889931077689315 1.012426877484229 1.0975803153407016 0.9831582397418938 1.1615837212072073 0.9354500736901599 0.922571921354053 1.0 10.75071144428772 GSSPTPPCS(ph)PVQPSK ddPTM_A459_Selumetinib_30min_R2 1 GSSPTPPCSPVQPSK 15 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GS(0.003)S(0.02)PT(0.176)PPCS(0.801)PVQPSK 102.39 0.0063284 4513100.0 11075.0 12431.0 11906.0 13911.0 12445.0 9583.9 12278.0 11217.0 12201.0 13742.0 True False 10459.4958367377 13384.41772803503 11139.980922272664 12016.29780218649 10881.547840288396 10903.9952310179 12848.951328395453 11249.639612925692 14641.540924423605 13345.232753996079 0.7837627135881705 1.0029362525750791 0.8347535878635705 0.900418750552578 0.8153883893130331 0.8170704424583993 0.9628120816812266 0.8429706562860145 1.0971364227453704 1.0 13.704036847270437 -8.257898495380225 24.995989107307743 1.048568219635867 0.8737906015516911 0.5186450268337754 0.0687291819718927 217.22122872702258 1533447.4652823394 0.048141593954709336 0.016546041079550128 5.522064875697401e-09 8.257898495380225 -0.1747776180841759 GSSQPNLST(ph)SHSEQEYGK ddPTM_A459_Selumetinib_30min_R2 1 GSSQPNLSTSHSEQEYGK 18 0 I3L2B2;O95208-3;O95208-2;O95208;F6PQP6;E9PBC1 I3L2B2 EPN2 Epsin-2 1 GS(0.03)S(0.13)QPNLS(0.163)T(0.468)S(0.184)HS(0.025)EQEYGK 103.87 0.004568399999999999 8238300.0 31486.0 24966.0 33583.0 44895.0 48990.0 29604.0 26137.0 31792.0 29221.0 37944.0 True False 29736.134168444514 26880.81192165737 31422.30634240574 38780.22355180523 42835.438223843164 33681.68228164463 27352.42228948298 31884.509456551066 35066.01650295732 36848.458129648316 0.8069844893867835 0.7294962472263944 0.8527441292617699 1.0524245930551601 1.162475728920058 0.9140594747041615 0.7422948931335389 0.8652874794480682 0.9516277826220131 1.0 15.169316632648659 -5.531741953841885 8.6016125373802 0.9483434348377434 0.7736689080543032 0.33718112739034756 0.10628252519760555 0.174563355701583 109.65614543471877 0.032905145120986315 0.05913292044867818 2.939395643423683e-06 5.531741953841885 -0.1746745267834402 GSSS(ph)SPGAADASR ddPTM_A459_Selumetinib_30min_R2 1 GSSSSPGAADASR 13 0 H7C3S3;B7XGB9 H7C3S3 PPM1M;ppm1m 1 GS(0.002)S(0.008)S(0.873)S(0.117)PGAADASR 113.52 0.0045397 1167300.0 6256.9 4925.5 5329.4 7024.8 5890.9 4264.7 5045.4 7320.0 4825.5 3847.5 True False 5909.1665463552235 5303.270012021285 4986.512206211985 6068.010121544077 5150.832476685807 4852.123713907916 5280.021097270432 7341.2999881087635 5790.734835735279 3736.412677994466 1.5815080012861404 1.419348040235169 1.3345721246424298 1.624020322295102 1.3785502086055805 1.2986048737293956 1.413125784624118 1.9647990253713716 1.5498113658161226 1.0 11.867438090784706 GSSS(ph)SSPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R2 1 GSSSSSPEHSASSDSTK 17 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 GS(0.081)S(0.081)S(0.291)S(0.273)S(0.273)PEHSASSDSTK 73.722 0.016184999999999998 30374000.0 19547.0 16091.0 28967.0 36338.0 43733.0 28151.0 30223.0 34844.0 32060.0 38726.0 True False 18460.655992840806 17325.127959280166 27103.294756884934 31388.70171345357 38238.86956201947 32028.544720665395 31628.42938573837 34945.39027126528 38472.89583124506 37607.87975776835 0.49087202234599625 0.4606781363605444 0.7206812756118331 0.8346309846667137 1.0167781275710122 0.8516445204292465 0.8410053847612918 0.9292039459907839 1.0230009263762878 1.0 15.198747352527585 -5.527563760578664 1.7809272458740002 0.929869607538256 0.45769505748853845 0.8894109322894943 0.06423589473140612 0.11713449816596104 0.7194486982324283 0.019896272577374023 0.05570734344896923 2.9678109948048254e-06 5.527563760578664 -0.47217455004971753 GSSSQGPSQT(ph)STPTDVTAIHL ddPTM_A459_Selumetinib_30min_R2 1 GSSSQGPSQTSTPTDVTAIHL 21 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 GS(0.003)S(0.004)S(0.02)QGPS(0.005)QT(0.323)S(0.323)T(0.323)PTDVTAIHL 104.26 0.00037645 6893900.0 6127.7 7327.8 5719.8 10838.0 11270.0 6625.0 5357.6 6321.8 5431.6 6588.0 True False 5787.146965126644 7889.818697409317 5351.794295247366 9361.84570340718 9854.161844921668 7537.533614237795 5606.739015882999 6340.195391369673 6518.071771584238 6397.787322320347 0.9045544457122974 1.2332105304413028 0.8365070649623251 1.463294297193335 1.5402452986429946 1.17814694901488 0.8763559545536049 0.990998148570874 1.0188009452649742 1.0 12.643357319295488 -7.176822576742511 6.828887848508317 0.9714126796020697 1.2078492875857298 0.21731388727358392 0.2047438727197657 0.4165790113896017 28.57900688733414 0.0840120861000366 0.06488103555043614 6.655449971972597e-08 7.176822576742511 0.23643660798366017 GSSSQGPSQTST(ph)PTDVTAIHL ddPTM_A459_Selumetinib_30min_R1 3 GSSSQGPSQTSTPTDVTAIHL 21 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 GSSSQGPSQT(0.009)S(0.192)T(0.718)PT(0.081)DVTAIHL;GSSSQGPSQT(0.008)S(0.152)T(0.837)PT(0.002)DVTAIHL;GSSSQGPSQT(0.001)S(0.009)T(0.915)PT(0.075)DVTAIHL 231.21 1.2403e-24 42816400.0 5202.5 5631.8 6497.9 7043.900000000001 5960.4 5707.5 6278.099999999999 5097.8 2440.16 3889.8 True False 5323.708127697201 4972.426237847213 5615.520870409784 5813.815095379013 5421.282872394088 5650.087731995367 5804.537862472694 4962.589784011894 4140.773297765026 4389.093719860562 1.2129401802489495 1.1329050039070898 1.279426056682195 1.3246049108205677 1.2351713630225964 1.2873016829029722 1.3224912095650352 1.1306638911710347 0.9434233037741047 1.0 12.099707360905326 -8.041858667099845 3.700689448682156 0.9776120862559075 1.255102990163722 0.8074663437622582 0.0553789460442841 0.10547558470727217 2.9203584233648536 0.043770674599672335 0.015937966687626832 9.081160112242536e-09 8.041858667099845 0.2774909039078146 GSSSQGPSQTST(ph)PTDVTAIHL ddPTM_A459_Selumetinib_30min_R2 4 GSSSQGPSQTSTPTDVTAIHL 21 0 Q5T8J1;P30281-4;P30281-2;P30281-3;P30281 Q5T8J1 CCND3 G1/S-specific cyclin-D3 1 GSSSQGPS(0.001)QT(0.004)S(0.029)T(0.768)PT(0.199)DVTAIHL;GSSSQGPSQT(0.006)S(0.111)T(0.829)PT(0.054)DVTAIHL;GSSSQGPSQT(0.005)S(0.097)T(0.892)PT(0.007)DVTAIHL;GSSSQGPSQT(0.011)S(0.175)T(0.434)PT(0.379)DVTAIHL 214.34 5.426900000000001e-18 31817100.0 43184.4 46079.3 50464.0 52184.0 63309.0 42068.5 48661.0 53292.0 45882.2 57442.0 True False 40784.38392885018 49613.434141697806 47217.20118104885 45076.44917757888 55355.55743035898 47863.05401517931 50923.832919942266 53447.07089703447 55059.92205578142 55783.50020776037 0.7311191262103058 0.8893926332502848 0.8464366883611255 0.8080606094937733 0.9923285061746294 0.8580145354256705 0.9128834284381809 0.9581161221145305 0.9870288140886812 1.0 15.767550840519272 -1.522878745528808 0.16832564304548306 1.0233171541137034 0.02854371193411078 0.6340858857489723 0.05108963610471429 40.568801030585774 0.4360019580337899 0.13399722697804686 10.13370727845408 0.029999999982836274 1.522878745528808 -0.9947734421795926 GSSSS(ph)PGAADASR ddPTM_A459_Selumetinib_30min_R2 1 GSSSSPGAADASR 13 0 H7C3S3;B7XGB9 H7C3S3 PPM1M;ppm1m 1 GS(0.008)S(0.001)S(0.035)S(0.956)PGAADASR 94.688 0.015607 1932700.0 7397.4 5815.9 5749.8 5421.1 8142.4 4680.8 5268.3 5779.4 5377.6 6319.4 True False 6986.282122138458 6261.96082893403 5379.864127908901 4682.736828080887 7119.478918020426 5325.537711928192 5513.286388938407 5796.217097168826 6453.270262698175 6136.942502226959 1.1383978454423018 1.0203714352320727 0.8766359023172644 0.7630406878313797 1.1601019425286985 0.8677835436776007 0.898376738406423 0.9444796158780221 1.0515448466979165 1.0 12.583304351412625 -4.912746447981729 3.450132809820744 0.9401247313797306 1.139571762682326 0.2465432793332769 0.10355244382542274 0.3548933429868794 7.5656443958651325 0.026268587650354752 0.1535119591170653 1.2225131857374781e-05 4.912746447981729 0.19944703130259545 GSSSS(ph)SPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R1 1 GSSSSSPEHSASSDSTK 17 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 GS(0.001)S(0.011)S(0.043)S(0.768)S(0.177)PEHSASSDSTK 69.431 0.034295 1853900.0 288.62 353.39 59.775 145.14 1075.7 60.354 564.92 209.72 0.0 0.0 True False 295.3442844432419 312.01493451344606 51.65788332057203 119.79402361522872 978.4031249302601 59.746893557047486 522.3076295802986 204.15754433343298 0.0 0.0 0.0 GSSSS(ph)SPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R2 1 GSSSSSPEHSASSDSTK 17 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 GS(0.021)S(0.089)S(0.089)S(0.401)S(0.401)PEHSASSDSTK 68.411 0.024231 821260.0 3800.8 4377.4 7728.3 10256.0 9896.2 7502.6 9206.9 9585.0 8820.1 10599.0 True False 3589.566751807912 4713.13250444056 7231.0695919368245 8859.11510741318 8652.950882849493 8536.015048178193 9635.03909312625 9612.89076311783 10584.366454184796 10292.979330490793 0.3487393335352937 0.4578977916023686 0.7025244450376285 0.8606949283546999 0.8406653316806865 0.8293045943356787 0.9360787371431387 0.9339269471416947 1.0283093081544261 1.0 13.329373014180941 -4.9390576915831526 0.6333331970668522 0.9593685988182058 1.0118889264384502e-18 0.9498402383439748 0.048272591988458714 0.630662200689911 0.2193781646843354 0.025685509182966415 0.4274938852759926 1.1506475270279793e-05 4.9390576915831526 -0.9593685988182058 down GSSSSS(ph)PEHSASSDSTK ddPTM_A459_Selumetinib_30min_R1 4 GSSSSSPEHSASSDSTK 17 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 GSSS(0.005)S(0.069)S(0.925)PEHSASSDSTK;GSSS(0.001)S(0.066)S(0.933)PEHSASSDSTK;GSSSS(0.09)S(0.906)PEHS(0.003)ASSDSTK;GSS(0.001)S(0.006)S(0.071)S(0.856)PEHS(0.047)AS(0.009)S(0.009)DSTK 308.04 5.559399999999997e-103 36359200.0 5063.73 4548.7300000000005 3612.9300000000003 4061.3799999999997 5981.68 4164.83 4673.29 4459.3 638.98 3018.5900000000006 True False 5181.705056696616 4016.162576952797 3122.313950403922 3352.136224544699 5440.638100151381 4122.935591563079 4320.779972812638 4341.02487815219 1084.302390747286 3406.0554300565313 1.5213214121446679 1.179124256614385 0.9166949905897743 0.9841696042184089 1.5973427948766767 1.2104722533815748 1.2685583254706236 1.2745021234372984 0.3183454917318505 1.0 11.733886198250758 -8.241012847488403 24.639448596992363 0.6591727401808231 1.2337640208896303 0.4699039524628361 0.24828082902105197 506.7763075281722 611299.918319153 0.1671790898140045 0.06301110692534681 5.740994786954502e-09 8.241012847488403 0.5745912807088073 GSST(ph)PTKGIENK ddPTM_A459_Selumetinib_30min_R1 2 GSSTPTKGIENK 12 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;H0YBE9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 GSS(0.043)T(0.956)PTKGIENK;GSS(0.022)T(0.977)PT(0.001)KGIENK 211.83 4.6492e-05 18090000.0 3637.7 2669.3 14590.5 13057.099999999999 7289.6 5374.8 4050.5 4727.1 3095.7 1924.92 True False 3722.4513322679713 2356.777115076096 12609.190239879652 10776.922597122797 6630.256967083409 5320.73439192794 3744.967523923743 4601.721952215197 5253.176799017764 2172.0022323086014 1.7138340269159906 1.085071221391471 5.8053302396827915 4.961745635808166 3.052601359454483 2.449691032901278 1.7242005870054982 2.11865433827113 2.4185872007296285 1.0 11.084809870557075 -6.831774947023522 2.9130579111382255 1.9287903543104017 3.448594030376472 0.22087614628359298 1.3310767096682652 0.4676564945425577 8.050502572855747 0.5565174975339919 0.49647395992848625 1.4730756578320366e-07 6.831774947023522 1.5198036760660703 GSTDNLMDDIER ddPTM_A459_Selumetinib_30min_R1 3 GSTDNLMDDIER 12 0 P50990-2;P50990;P50990-3 P50990-2 CCT8 T-complex protein 1 subunit theta 0 ;; 242.97 1.9991e-11 14398000.0 3767.2 3662.9 3899.3999999999996 4062.1 4332.4 3317.7 3727.2999999999997 3326.1000000000004 2448.88 3053.47 False True 3854.968430304837 3234.04596516399 3369.8828978709917 3352.7304900607733 3940.535184947346 3284.3269502305784 3446.1467601335544 3237.881023304555 4155.570500881427 3445.4126178165043 1.1188698881435817 0.9386527315888029 0.9780781786323813 0.973099846655096 1.1437048684881814 0.9532463349228656 1.0002130781994742 0.939765822694563 1.2061169333950421 1.0 11.750461053086916 -8.247084174922767 24.997633780983737 1.1030584947793718 1.0041295785753341 0.18534997368039585 0.08158711915333798 1098.8616949079542 1913526.362585634 0.05287676229038253 0.019797026446171966 5.66129551218242e-09 8.247084174922767 -0.09892891620403765 GSTDNLMDDIER ddPTM_A459_Selumetinib_30min_R2 2 GSTDNLMDDIER 12 0 P50990-2;P50990;P50990-3 P50990-2 CCT8 T-complex protein 1 subunit theta 0 ; 179.6 0.001439 4598300.0 29685.0 27225.0 30312.0 32997.0 35139.0 27829.0 27406.0 30749.0 25597.0 28075.0 False True 28035.22653847031 29313.069957827534 28361.758921210232 28502.751677000055 30724.524673354255 31662.192143490378 28680.433303958765 30838.474499229007 30717.11523993697 27264.401802389773 1.028272204234203 1.0751407703820661 1.0402487143042425 1.0454200273156824 1.1269099133750735 1.161301552587709 1.051937009725439 1.1310893495021028 1.1266381511896792 1.0 14.73473088174446 -6.250963296648745 24.458977983761717 1.1068977917960074 1.048759611401611 0.23852536354107323 0.04470154505558947 693.7994938396855 1619842.0747021178 0.012655365147998055 0.016160039928279593 5.610953936534023e-07 6.250963296648745 -0.058138180394396555 GSTDS(ph)LDSLSSR ddPTM_A459_Selumetinib_30min_R2 1 GSTDSLDSLSSR 12 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 GS(0.001)T(0.004)DS(0.933)LDS(0.062)LSSR 186.51 0.00011085 14191000.0 57957.0 61388.0 70670.0 64777.0 61901.0 40114.0 52750.0 53655.0 51002.0 54991.0 True False 54735.98196025346 66096.26220646893 66123.16913967812 55954.260853442196 54124.442978038715 45639.33938136377 55202.97952214205 53811.1271669366 61203.82511494572 53403.266946223135 1.024955683242607 1.2376819993620913 1.238185843691246 1.0477684990655702 1.0135043429560555 0.8546169923896676 1.0337004209448688 1.0076373646040078 1.1460689320108022 1.0 15.704640381068023 -5.912305124662964 5.317969767363364 1.0053270952110072 1.1730010767054448 0.40102826884638554 0.08600147058855934 0.19883062853994848 9.258069442168779 0.025085343703216505 0.03773326602221617 1.223756116098055e-06 5.912305124662964 0.16767398149443768 GSTES(ph)CNTTTEDEDLKVR ddPTM_A459_Selumetinib_30min_R1 1 GSTESCNTTTEDEDLKVR 18 1 Q8WU40;Q13555-10;Q5SWX3;Q13555-5;Q13555-4;Q13555-11 Q8WU40 CAMK2G 1 GS(0.154)T(0.154)ES(0.688)CNT(0.005)TTEDEDLKVR 90.882 0.003068 4700700.0 281.87 390.43 423.4 487.69 415.95 527.0 439.18 450.03 176.73 413.76 True False 288.43702257645566 344.7182740940173 365.9046055697231 402.52409657510634 378.3273959419371 521.698858477715 406.0522990141535 438.0937424965421 299.89790215150356 466.8701263636965 0.6178099781688758 0.7383601019386671 0.7837395988893917 0.862175739772084 0.810348262992557 1.1174389386210297 0.8697328787703044 0.9383631930119742 0.6423583031266389 1.0 8.866877467526399 -5.118331410434143 0.9622864296339404 0.9014599847961922 0.5641001523417167 0.3746882990467699 0.11632349263985656 1.412241621916211 1.4896489357226734 0.04105984805295349 0.44301798642493967 7.6149768881163975e-06 5.118331410434143 -0.33735983245447543 GSTIYTGYPLS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 GSTIYTGYPLSPTK 14 0 Q5SQL3;J3KP92;Q86Z02;H3BLW0;Q86Z02-4;Q86Z02-3 Q5SQL3 HIPK1 Homeodomain-interacting protein kinase 1 1 GSTIYTGYPLS(0.957)PT(0.043)K 124.62 0.0014553 8692900.0 2519.5 2868.3 2789.3 3284.6 2785.1 2607.7 3012.6 2478.3 1935.1 2404.8 True False 2578.199447906412 2532.4781025635066 2410.5283805281747 2711.0062695782026 2533.1881967493437 2581.4689056021593 2785.3571565418265 2412.5674333470674 3283.723365887936 2713.4795047356374 0.9501451709537031 0.9332954599965682 0.8883532661003172 0.9990885373730967 0.9335571513727505 0.9513500658829044 1.0264891080550806 0.8891047192862853 1.2101522639684927 1.0 11.405928296519871 -8.250947845200693 24.994978923406894 1.1050761410327563 0.9482094667048365 0.5122341064562221 0.06190738925621268 461.6795887641279 1099909.582657082 0.03953958147872823 0.014598424755698352 5.611153568141546e-09 8.250947845200693 -0.1568666743279198 GSTIYTGYPLS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 GSTIYTGYPLSPTK 14 0 Q5SQL3;J3KP92;Q86Z02;H3BLW0;Q86Z02-4;Q86Z02-3 Q5SQL3 HIPK1 Homeodomain-interacting protein kinase 1 1 GST(0.001)IY(0.04)T(0.006)GY(0.001)PLS(0.951)PT(0.001)K 104.55 0.006123699999999999 6305200.0 28110.0 24864.0 24466.0 28284.0 30962.0 24768.0 26672.0 32940.0 21692.0 27911.0 True False 26547.758733245766 26770.98884963908 22891.88419656668 24431.67040737854 27072.276756208063 28179.56717848177 27912.300849565367 33035.84994648943 26031.006125120628 27105.136908512937 0.9794364375598444 0.9876721501167216 0.8445588846805272 0.9013667958897216 0.998787678054688 1.0396393596385558 1.0297790025476286 1.2188040244177414 0.9603716894322362 1.0 14.726278673568999 -6.608553315116216 2.29410048927537 1.0654129219897857 0.9273202143596466 0.3650778696927709 0.07398581622313113 0.3036254414570804 3.2507327101886747 0.027348524442540777 0.027815059406446314 2.4628994677535636e-07 6.608553315116216 -0.13809270763013903 GSTIYTGYPLSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GSTIYTGYPLSPTK 14 0 Q5SQL3;J3KP92;Q86Z02;H3BLW0;Q86Z02-4;Q86Z02-3 Q5SQL3 HIPK1 Homeodomain-interacting protein kinase 1 1 GSTIYTGYPLS(0.426)PT(0.574)K 145.69 0.0011975999999999998 4829600.0 29487.0 31293.0 26676.0 31567.0 32181.0 25559.0 30777.0 26623.0 20978.0 29586.0 True False 27848.23058581349 33693.07247714588 24959.69520263274 27267.520143887643 28138.13507820978 29079.52024849871 32208.19148346853 26700.468522325078 25174.186174293773 28731.77530634028 0.9692485162818387 1.1726763180453657 0.8687139912696189 0.9490370801372124 0.9793385468944725 1.0121031484637042 1.1209955229032125 0.9293010347478615 0.8761792790694193 1.0 14.810359517791408 -7.9431260736210625 24.999937215118244 0.9263023558907646 1.0088752801273093 0.1372453463566844 0.08545426253134501 148.10641624601539 65102.15342107213 0.047140921499485726 0.02264576112513829 1.1399188265154157e-08 7.9431260736210625 0.08257292423654472 GSTPY(ph)SQDSAYSSSTTSTSFKPR ddPTM_A459_Selumetinib_30min_R2 1 GSTPYSQDSAYSSSTTSTSFKPR 23 1 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 1 GS(0.036)T(0.182)PY(0.6)S(0.179)QDS(0.002)AYSSSTTSTSFKPR 93.255 0.00098662 5727100.0 13844.0 12682.0 12781.0 15560.0 19965.0 15282.0 15329.0 13236.0 14561.0 14811.0 True False 13074.605901922952 13654.668620942843 11958.68437490062 13440.701157502832 17456.818210635418 17386.95678381615 16041.828873837261 13274.514568662238 17473.606868333096 14383.367946400522 0.909008651565151 0.9493373646441383 0.8314244910833498 0.9344613311422938 1.2136808483025727 1.208823750362813 1.1153040743737475 0.9229072508003401 1.2148480754610687 1.0 13.812113910031385 -6.132357127291235 6.043355209943774 1.1130719435792689 0.8992488195883241 0.5453536981744929 0.09275536209035071 0.18799992219122788 8.452232530750287 0.02824084703733666 0.03674457528913279 7.372976891094609e-07 6.132357127291235 -0.21382312399094472 GSTSSSPYVAAS(ph)HTPPINGSDSILGTR ddPTM_A459_Selumetinib_30min_R1 1 GSTSSSPYVAASHTPPINGSDSILGTR 27 0 Q99081;Q99081-3;B4DGI9;Q99081-4;Q99081-2;F5GY10 Q99081 TCF12 Transcription factor 12 1 GSTSSSPY(0.002)VAAS(0.919)HT(0.078)PPINGSDSILGTR 62.871 0.0016649000000000002 8010700.0 1033.0 1231.8 1502.3 1402.1 1148.0 1318.3 1379.0 1086.8 656.47 946.92 True False 1057.0668901319004 1087.5802833517155 1298.2959115432097 1157.2495556766721 1044.1636026958615 1305.0390989206305 1274.9809197607312 1057.9745335760774 1113.9816433282276 1068.4664057818813 0.9893309554813388 1.0178890767799544 1.2151022292489804 1.0830940022207072 0.9772544995757395 1.2214133189949292 1.19328124203187 0.9901804379164114 1.0425986603790685 1.0 10.061325832834074 -7.800191779857527 24.99989311932384 1.0122920577661456 1.1002635793520525 0.1853138107983977 0.08520190380631101 310.93884669772893 200588.4822047223 0.04903273964183627 0.02355521327705526 1.5841934748674075e-08 7.800191779857527 0.08797152158590693 GSTSSSPYVAASHT(ph)PPINGSDSILGTR ddPTM_A459_Selumetinib_30min_R1 1 GSTSSSPYVAASHTPPINGSDSILGTR 27 0 Q99081;Q99081-3;B4DGI9;Q99081-4;Q99081-2;F5GY10 Q99081 TCF12 Transcription factor 12 1 GSTSSSPYVAAS(0.027)HT(0.971)PPINGS(0.001)DSILGTR 61.725 0.029803 0.0 795.04 803.54 828.58 652.78 720.12 795.88 935.7 665.6 353.2 656.46 True False 813.5628851214576 709.4611632443886 716.0633870641501 538.7842271982156 654.985273147512 787.8741698012217 865.1193956636082 647.9461258264969 599.354603292656 740.7230354618914 1.0983361474834459 0.9577954637282086 0.9667086789296835 0.7273760925529295 0.8842512542344304 1.0636555528611693 1.1679391003739301 0.8747481782073352 0.8091480548042055 1.0 9.532790393494569 -4.716490363314637 2.7814907416384047 0.9365238334473146 1.1456273328594897 0.14116073404028262 0.11882307987898033 1.339726624456336 12.003509549637513 0.03348286902413335 0.6967182857010384 1.9209215851615202e-05 4.716490363314637 0.2091034994121751 GSTTTYSS(ph)FRKNY(ph)Y(ph)S(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GSTTTYSSFRKNYYSK 16 2 A0A0G2JNU3;A6H8Y1-2;A6H8Y1-7;A6H8Y1-6;A6H8Y1;A0A0G2JN16;A0A0A0MRX7;A6H8Y1-4;A6H8Y1-3 A0A0G2JNU3 BDP1 Transcription factor TFIIIB component B homolog 4 GS(0.021)T(0.021)T(0.064)T(0.066)Y(0.15)S(0.154)S(0.896)FRKNY(0.876)Y(0.872)S(0.879)K 47.037 0.045245 2489900.0 4758.0 4240.8 5391.0 4903.8 5221.2 3990.5 4806.3 3589.0 4036.9 6069.1 True False 4493.569407783115 4566.055723678786 5044.148929276995 4235.893980473163 4565.266177879771 4540.155152847689 5029.802473502771 3599.4433958090663 4844.392800410266 5893.869313584462 0.7624141576105409 0.7747127533273821 0.8558297887011181 0.7186949277463751 0.77457879280722 0.7703182597522701 0.8533956567224608 0.6107097399518009 0.8219376003544371 1.0 12.524999356197316 -8.544595164300725 23.495431408378984 1.0000000035480052 0.7669418678418533 0.541328755278527 0.06500936437696755 1843.041740883638 1994021.7186884978 0.06050554930372046 0.015622465630329879 2.853677136407377e-09 8.544595164300725 -0.23305813570615197 GSVFLESDS(ph)SPPSSSDAGLR ddPTM_A459_Selumetinib_30min_R1 2 GSVFLESDSSPPSSSDAGLR 20 0 Q8TBP0 Q8TBP0 TBC1D16 TBC1 domain family member 16 1 GSVFLES(0.003)DS(0.622)S(0.364)PPS(0.009)S(0.002)S(0.001)DAGLR;GSVFLES(0.04)DS(0.479)S(0.479)PPS(0.001)SSDAGLR 259.22 1.5835999999999996e-47 16027400.0 3525.8 5505.2 2896.8 3550.8 4132.3 3660.8 4663.1 4049.5 1884.24 4034.1000000000004 True False 3607.9442799874682 4860.648624701955 2503.430470983405 2930.719436771079 3758.5341946168205 3623.9756757404557 4311.35861271665 3942.0941053701954 3197.417660555362 4551.916030461591 0.7926210096677908 1.0678247560311558 0.549972902450387 0.6438430360223246 0.8257037628692117 0.7961429102577192 0.9471524922395049 0.8660296189537671 0.7024333575483652 1.0 12.152258229047794 -6.929567571321702 2.8250293611469846 0.8675033798328295 0.7713602529820319 0.09776122006424226 0.1444340418066828 0.7811082065898831 12.640721458932152 0.0594059070534106 0.05006524538576232 1.1760679875384073e-07 6.929567571321702 -0.09614312685079762 GSVFLESDS(ph)SPPSSSDAGLR ddPTM_A459_Selumetinib_30min_R2 3 GSVFLESDSSPPSSSDAGLR 20 0 Q8TBP0 Q8TBP0 TBC1D16 TBC1 domain family member 16 1 GSVFLES(0.146)DS(0.425)S(0.425)PPS(0.002)S(0.002)S(0.002)DAGLR;GSVFLES(0.05)DS(0.474)S(0.474)PPS(0.002)SSDAGLR;GSVFLES(0.024)DS(0.773)S(0.202)PPSSSDAGLR 242.1 2.9424e-30 4098300.0 38002.6 33635.0 35482.9 45434.0 44433.0 35576.0 36491.1 45983.0 34880.1 39858.9 True False 35890.5676284612 36214.69634642898 33199.96884486046 39245.81082197839 38850.92930394005 40476.27107322626 38188.00845574289 46116.80291710454 41857.09463142265 38708.06999114065 0.9272114997383153 0.935585172671168 0.8577014780757382 1.0138922150073826 1.003690685503878 1.0456804248439746 0.986564519090805 1.1914002151918082 1.0813531814167625 1.0 15.240346755285449 -6.394177711996659 0.913865578739032 1.0827951598973489 0.90764525450158 0.5282522478527248 0.05957587906536688 0.43842991899973993 0.7935629223364468 0.031064246899330593 0.042961055268272326 4.034802562750415e-07 6.394177711996659 -0.1751499053957689 GSVFLESDSS(ph)PPSSSDAGLR ddPTM_A459_Selumetinib_30min_R2 1 GSVFLESDSSPPSSSDAGLR 20 0 Q8TBP0 Q8TBP0 TBC1D16 TBC1 domain family member 16 1 GSVFLESDS(0.148)S(0.847)PPS(0.005)SSDAGLR 243.37 2.0500999999999998e-30 3839400.0 23922.0 20801.0 25745.0 27160.0 32234.0 21817.0 21401.0 26063.0 21050.0 23415.0 True False 22592.51100735342 22396.36981424316 24088.594729036588 23460.76114638669 28184.476744383774 24822.093714992618 22396.18890527701 26138.839015038087 25260.588186141864 22738.94811052383 0.9935600757581817 0.9849342944706347 1.0593539600843773 1.0317434664239722 1.2394802348548257 1.091611344304211 0.9849263385632079 1.1495183896805126 1.1108951945956986 1.0 14.472877897155561 -5.553742374777151 1.9071036006710012 1.0969654350059126 0.9887055543636191 0.23150918111247265 0.06996001244067267 0.5003022498740826 3.577165727482798 0.021171273573829096 0.054534628583926784 2.7942008808404097e-06 5.553742374777151 -0.10825988064229353 GSVIS(ph)PTELEAPILVPHTAQR ddPTM_A459_Selumetinib_30min_R2 1 GSVISPTELEAPILVPHTAQR 21 0 Q8N1B4-2;Q8N1B4 Q8N1B4-2 VPS52 Vacuolar protein sorting-associated protein 52 homolog 1 GS(0.108)VIS(0.718)PT(0.174)ELEAPILVPHTAQR 69.845 0.020922 0.0 3852.3 4406.7 5362.1 3259.5 3264.6 3062.7 2611.6 2792.7 2018.8 4467.7 True False 3638.204587978748 4744.679720226208 5017.108323813052 2815.550477048873 2854.4717621057025 3484.559124577523 2733.044574787224 2800.826294643628 2422.61640998495 4338.705892521346 0.8385460268809517 1.093570257528781 1.1563605480751928 0.6489378507775913 0.6579085637092786 0.8031332869517335 0.6299216039276112 0.6455441700880047 0.5583730425611076 1.0 12.08304907828808 -5.769532004366492 24.999999999984674 0.6903317605640055 1.035900086263364 0.5321352092022145 0.1382884823224314 120.46376802751833 372141.36234759627 0.037461029360407495 0.056671115933152945 1.700074665802448e-06 5.769532004366492 0.3455683256993586 GSVPLSS(ph)SPPATHFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R1 1 GSVPLSSSPPATHFPDETEITNPVPK 26 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 GS(0.007)VPLS(0.055)S(0.312)S(0.312)PPAT(0.312)HFPDET(0.002)EIT(0.001)NPVPK 57.147 0.005989199999999999 543650000.0 1583.0 2160.2 1551.9 1561.2 1619.9 1280.5 1724.2 1388.8 771.71 1234.2 True False 1619.8808200181968 1907.282779750265 1341.1605039765077 1288.5657273535553 1473.380331016573 1267.6193326009757 1594.1422058386156 1351.9645125418258 1309.5355065316414 1392.6215921260498 1.1631880685873908 1.3695628378406126 0.9630473285488997 0.9252805892420228 1.0579904400069173 0.9102396083531643 1.1447059379604432 0.970805364634513 0.9403383617888872 1.0 10.443587581849597 -5.271195051551642 24.974603409431314 0.9909373072510351 1.2663754554045796 0.6575034501451228 0.08005289474738188 329.3467730290965 843131.8252357027 0.020026494806216676 0.04254030095059427 5.355560730509007e-06 5.271195051551642 0.2754381481535445 GSVPLSS(ph)SPPATHFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 1 GSVPLSSSPPATHFPDETEITNPVPK 26 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 GSVPLS(0.034)S(0.391)S(0.293)PPAT(0.282)HFPDETEITNPVPK 90.454 2.7719e-05 186210000.0 136780.0 113790.0 162590.0 158180.0 172230.0 131120.0 157250.0 163960.0 140330.0 161460.0 True False 129178.31517372302 122517.32710748188 152129.13641460726 136635.61112427985 150592.92764426427 149180.5898111486 164562.43658496378 164437.096454961 168399.9211478043 156798.23027653972 0.8238505941418829 0.7813693234381678 0.9702222795901603 0.8714104163248543 0.9604249192013752 0.9514175609510633 1.049517180740692 1.04871780864458 1.0739912105564142 1.0 17.25854975081807 -5.93733020824229 0.524398478315393 1.0558028016121597 0.767090999479197 0.7608866919262397 0.045994645885319846 0.704692254089117 0.3313135186722589 0.03397473470940652 0.11008850352091579 1.1552335464853392e-06 5.93733020824229 -0.28871180213296266 GSVPLSSS(ph)PPATHFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 1 GSVPLSSSPPATHFPDETEITNPVPK 26 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 GS(0.002)VPLS(0.03)S(0.448)S(0.512)PPAT(0.007)HFPDETEITNPVPK 59.539 0.024814 0.0 5536.0 6074.2 7291.4 8658.7 8628.7 4689.3 4105.3 6279.0 6066.0 7063.1 True False 5228.331282363876 6540.071608368633 6822.27926227607 7479.370122909365 7544.6855644432635 5335.208509772874 4296.2045844976265 6297.2708504555885 7279.369498201262 6859.1699508623005 0.7622396470445518 0.9534785776151308 0.9946216978365446 1.09041912891648 1.0999414824959663 0.7778213031595985 0.6263446765825549 0.9180805980268687 1.0612609908121808 1.0 12.743818286682803 -6.771415462325803 24.99963636733553 0.8559342612437899 0.9855900651285597 0.1085928911935169 0.1416519486332131 418.5397698028251 1048836.7418486082 0.05322631979721578 0.047492402053828216 1.6927177086539093e-07 6.771415462325803 0.12965580388476983 GSVPLSSSPPAT(ph)HFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R1 3 GSVPLSSSPPATHFPDETEITNPVPK 26 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 GSVPLS(0.013)S(0.075)S(0.243)PPAT(0.669)HFPDETEITNPVPK;GS(0.001)VPLS(0.024)S(0.074)S(0.172)PPAT(0.715)HFPDET(0.009)EIT(0.004)NPVPK;GSVPLS(0.027)S(0.085)S(0.272)PPAT(0.615)HFPDETEITNPVPK 104.97 5.0046e-08 2672970000.0 12355.699999999999 23541.2 13105.900000000001 14442.699999999999 15097.5 13866.5 16168.600000000002 14743.5 5710.700000000001 11673.3 True False 12643.563769992954 20784.985359993025 11326.19076555559 11920.553568056108 13731.933790680121 13727.015599774648 14948.989484585465 14352.454486362616 9690.64080697443 13171.681762570905 0.9599050446178659 1.57800543124693 0.8598894939703505 0.9050137850984189 1.0425345858037087 1.0421611945394702 1.134934001143652 1.0896447959399562 0.7357178059457588 1.0 13.685151940452995 -5.288135513166611 24.940111617210665 0.9872848336987687 1.2689554754910115 0.3011926085567702 0.17771091333213407 751.9047173339577 702444.5539099054 0.04456281021056319 0.09280444942332859 5.150679025595382e-06 5.288135513166611 0.28167064179224277 GSVPLSSSPPAT(ph)HFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 5 GSVPLSSSPPATHFPDETEITNPVPK 26 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 GS(0.003)VPLS(0.025)S(0.072)S(0.218)PPAT(0.679)HFPDET(0.004)EIT(0.001)NPVPK;GSVPLSS(0.001)S(0.002)PPAT(0.996)HFPDETEITNPVPK;GSVPLS(0.013)S(0.053)S(0.043)PPAT(0.891)HFPDETEITNPVPK;GSVPLS(0.021)S(0.075)S(0.205)PPAT(0.699)HFPDETEITNPVPK;GSVPLS(0.021)S(0.07)S(0.057)PPAT(0.851)HFPDETEITNPVPK 103.25 8.247e-07 3544738000.0 521696.0 468437.0 552521.0 561444.0 654360.0 524847.0 527274.0 646971.0 541910.0 595259.0 True False 492702.22483455617 504364.61163764296 516972.40039937897 484974.35865507904 572153.4467473776 597139.9101633003 551793.2857736093 648853.5784981858 650307.1422305066 578072.3260013792 0.8523193425339318 0.8724939578519793 0.894304012052197 0.8389510046428377 0.9897610056946621 1.0329847725003802 0.9545402209278097 1.1224435928050944 1.1249580943076578 1.0 19.140890482449407 -6.638646126968065 0.992362783955794 1.0731093217818113 0.8576721621552548 0.7300112926758147 0.05169418432613371 0.27760436658802645 0.5910865712585768 0.028694051497561806 0.02972393108959804 2.2980203647650056e-07 6.638646126968065 -0.21543715962655652 GSVPLSSSPPATHFPDET(ph)EITNPVPK ddPTM_A459_Selumetinib_30min_R1 1 GSVPLSSSPPATHFPDETEITNPVPK 26 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 GSVPLSSSPPAT(0.011)HFPDET(0.797)EIT(0.191)NPVPK 59.94300000000001 0.0047897 25483000.0 12303.0 17810.0 11740.0 13105.0 12617.0 12893.0 14479.0 13300.0 5243.1 10195.0 True False 12589.635962529308 15724.796920355633 10145.772483203938 10816.457761317166 11475.794577712273 12763.308125907362 13386.83737289023 12947.240795511436 8897.157759127196 11503.627557709513 1.0944057341366178 1.3669424571918771 0.8819628793010109 0.9402649474746061 0.9975805040751179 1.1095028991401616 1.1637057359283702 1.1254920007241056 0.7734219240403424 1.0 13.489801252394829 -5.262559760028355 24.9993290053488 1.0111549568071616 1.23067409143968 0.3437526823329473 0.12716008188550568 112.44319194468757 2509038.0927719474 0.03373584124860229 0.07732826809549011 5.463113708715904e-06 5.262559760028355 0.2195191346325185 GSVSQPST(ph)PSPPKPTGIFQTSANSSFEPVK ddPTM_A459_Selumetinib_30min_R1 1 GSVSQPSTPSPPKPTGIFQTSANSSFEPVK 30 1 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 GS(0.001)VS(0.079)QPS(0.392)T(0.394)PS(0.114)PPKPT(0.021)GIFQTSANSSFEPVK 127.31 1.1565999999999997e-17 16286000.0 3318.3 3648.8 3788.0 3667.9 3567.5 2848.9 3412.2 3438.4 1932.1 3086.2 True False 3395.609933712183 3221.5967997188995 3273.610405994594 3027.3701200103164 3244.8202548932827 2820.242652594235 3154.8150068220175 3347.2024625027448 3278.6325849992636 3482.3438321337017 0.9750932410461104 0.9251231225335274 0.9400595012436747 0.8693484233449131 0.9317920375786433 0.8098690963741556 0.9059458683288604 0.9611924105873965 0.9415016847978449 1.0 11.765842940386506 -7.767288051683754 7.147069083558104 0.9638543601049345 0.9056166603754697 0.2743696887656314 0.044012073008289986 0.19598801161251436 54.64164916448522 0.023640701657633996 0.012169613449991859 1.7088815003756074e-08 7.767288051683754 -0.0582376997294648 GSVSQPSTPS(ph)PPKPTGIFQTSANSSFEPVK ddPTM_A459_Selumetinib_30min_R1 1 GSVSQPSTPSPPKPTGIFQTSANSSFEPVK 30 1 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 GSVS(0.016)QPS(0.092)T(0.092)PS(0.663)PPKPT(0.133)GIFQT(0.001)S(0.001)ANSSFEPVK 101.73 1.6648e-08 23802000.0 3320.4 3955.6 4458.7 4967.2 3528.4 3671.0 3904.4 3779.8 2099.0 3435.3 True False 3397.758859626296 3492.47651309145 3853.23302988598 4099.7717658919955 3209.2568429896173 3634.0730730013133 3609.8879645495253 3679.547425479256 3561.849695105563 3876.2542176556594 0.8765572815503428 0.9009926379915515 0.9940609705976399 1.0576632841102767 0.8279273398457754 0.9375218623300676 0.9312825634879976 0.9492533819684895 0.9188896019466322 1.0 11.920447475261376 -10.978322143993584 2.6234588628810536 1.0024167752086757 0.9347396699993287 0.10337546895217964 0.05919773950267778 15360051.38341359 15572980.355666408 273107.2469059283 0.015340629670044086 1.0511818557510482e-11 10.978322143993584 -0.067677105209347 GSVSQPSTPS(ph)PPKPTGIFQTSANSSFEPVK ddPTM_A459_Selumetinib_30min_R2 2 GSVSQPSTPSPPKPTGIFQTSANSSFEPVK 30 1 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 GSVSQPS(0.002)T(0.015)PS(0.921)PPKPT(0.023)GIFQT(0.03)S(0.008)ANS(0.001)SFEPVK;GSVSQPS(0.003)T(0.01)PS(0.975)PPKPT(0.01)GIFQT(0.001)SANSSFEPVK 132.53 3.9514e-18 19017700.0 147229.0 132349.0 150142.0 151114.0 142831.0 125012.0 131979.0 141281.0 98430.0 144410.0 True False 139046.6015843843 142499.74273089154 140482.0271822494 130532.01251381013 124887.29285465898 142231.26825405224 138116.2850114272 141692.10431967123 118118.75036398771 140240.5080777598 0.9914867215632627 1.0161097152605798 1.0017221779056569 0.9307725300127511 0.8905222504286148 1.0141953291782757 0.9848529993548314 1.0103507628559543 0.8422584314832479 1.0 17.097543602400584 -5.704552633800945 9.694242010988116 0.9549691243009351 1.0045936931783772 0.15993597226258027 0.05220160020597967 0.7403351095307262 119.80437814784824 0.014217415985386611 0.024612468371662206 1.97445557312382e-06 5.704552633800945 0.049624568877442155 GSVSS(ph)VSPKPPSSFK ddPTM_A459_Selumetinib_30min_R2 2 GSVSSVSPKPPSSFK 15 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 GS(0.002)VS(0.187)S(0.539)VS(0.272)PKPPSSFK;GS(0.004)VS(0.391)S(0.528)VS(0.076)PKPPSSFK 85.163 0.01155 63475000.0 466080.0 401390.0 464480.0 477040.0 465980.0 401650.0 465970.0 407890.0 341130.0 402910.0 True False 440177.1394660679 432175.3223277271 434595.8624875861 412066.3290601001 407439.4264859453 456973.64168431866 487638.52830203844 409076.8923701752 409365.53196857753 391276.94141410023 1.1249759259394105 1.104525405370982 1.1107116635008658 1.0531321563976288 1.041307021603248 1.1679033270726005 1.2462746374465135 1.0454919497472681 1.046229635943033 1.0 18.57783056681778 -7.972285176917314 24.995532619071938 1.030696561706351 1.118422745006539 0.363827134013317 0.05521161695094147 255.40242322504545 230342.95271247166 0.033114146293196006 0.015907002684563513 1.0658959770581863e-08 7.972285176917314 0.08772618330018789 GSVSSVS(ph)PKPPSSFK ddPTM_A459_Selumetinib_30min_R1 1 GSVSSVSPKPPSSFK 15 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 GSVS(0.068)S(0.243)VS(0.602)PKPPS(0.068)S(0.019)FK 126.07 0.0055780000000000005 13965000.0 1651.1 2310.4 2502.2 2400.1 2011.7 1871.2 1779.6 1813.2 1139.5 1758.1 True False 1689.5674175186653 2039.89729392418 2162.414983600758 1980.9675904568733 1829.742090194481 1852.3774269136627 1645.3633392358208 1765.1080458963409 1933.6482742128574 1983.7692603441956 0.8516955329903214 1.028293630061717 1.090053680550311 0.9985877037499632 0.9223563076468935 0.9337665745421745 0.8294126600945216 0.889774875123372 0.9747344677966016 1.0 10.954028514864657 -6.275105762191251 5.007279985243972 0.9145730803690042 1.0021796650107204 0.16370750617829266 0.07086116481908558 0.2771246671920871 21.19512219477636 0.022485778918841966 0.026933355095764916 5.307551755703983e-07 6.275105762191251 0.08760658464171622 GSVSSVS(ph)PKPPSSFK ddPTM_A459_Selumetinib_30min_R2 1 GSVSSVSPKPPSSFK 15 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 GSVS(0.04)S(0.003)VS(0.94)PKPPS(0.016)S(0.001)FK 161.94 5.3347e-05 0.0 20661.0 17333.0 18384.0 19589.0 20920.0 18062.0 18398.0 17381.0 16439.0 18063.0 True False 19512.744332536127 18662.38536562073 17201.19345498577 16920.94440709017 18291.842572827092 20549.876549488763 19253.543454945397 17431.57583242054 19727.259344037346 17541.4742566898 1.1123776740198759 1.0639006216084401 0.9806013567203876 0.9646249887256211 1.0427768102701587 1.1715022493991147 1.0976012148809366 0.9937349379726539 1.124606692422899 1.0 14.098482382374062 -6.53746449480836 24.991203646034474 1.0815528029117853 1.0260260875395653 0.11178970650257336 0.06268134239285555 489.12657603806616 838062.9559948463 0.021495547268026424 0.02150258712203745 2.900918349880035e-07 6.53746449480836 -0.05552671537222009 GSWS(ph)SAPTSR ddPTM_A459_Selumetinib_30min_R1 2 GSWSSAPTSR 10 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 GSWS(0.753)S(0.244)APT(0.003)SR;GSWS(0.711)S(0.259)APT(0.03)SR 128.51 0.0031049 74109000.0 10570.8 13290.8 12812.8 14250.7 13050.4 10563.0 12315.9 11564.9 6382.6 10067.3 True False 10817.079072803765 11734.706957274706 11072.892135672528 11762.082763769748 11869.993624235256 10456.745810436638 11386.901747412028 11258.161283910544 10830.806033340048 11359.536018806175 0.9522465578607832 1.0330269597145008 0.9747662331754486 1.035436900265745 1.044936483724687 0.920525784955043 1.0024090533768764 0.9910758032081767 0.953454966418453 1.0 13.47161628859647 -6.740671429980002 24.999568829342387 0.9747425620009089 1.0091371755146687 0.19848243688579315 0.034676606279967444 408.3782170705713 491587.29035168845 0.011174920341859818 0.0111640417649382 1.8168897298005604e-07 6.740671429980002 0.03439461351375983 GSWSS(ph)APTSR ddPTM_A459_Selumetinib_30min_R2 2 GSWSSAPTSR 10 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 GS(0.003)WS(0.42)S(0.577)APTSR;GSWS(0.462)S(0.537)APT(0.001)SR 121.29 0.004823600000000001 51931000.0 544330.0 444560.0 542430.0 575730.0 554020.0 426780.0 393880.0 482380.0 346970.0 440460.0 True False 514078.3177256377 478656.3225142985 507530.64435312944 497314.580810353 484419.0545983592 485565.0710768916 412196.20045841305 483783.64593769185 416373.6951518122 427742.7753474833 1.201839861136213 1.1190284210538795 1.1865323591750423 1.162648697938503 1.1325008451746126 1.135180063958849 0.9636543834634244 1.1310153527308158 0.9734207545961817 1.0 18.706383961978197 -7.117483585779898 5.638808168390281 1.028409824888565 1.157415371514635 0.6632088509237861 0.048558329569084 0.1474372983426211 6.263956977897277 0.0176405557308739 0.013636341583900154 7.62985727767857e-08 7.117483585779898 0.12900554662607 GSYGS(ph)DAEEEEYR ddPTM_A459_Selumetinib_30min_R1 1 GSYGSDAEEEEYR 13 0 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;A0A3B3IS03 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 GS(0.001)YGS(0.998)DAEEEEYR 116.63 0.0037721 8395500.0 1031.6 1548.6 1194.1 966.42 1153.8 1207.0 1374.3 1119.9 675.59 1086.9 True False 1055.6342728558263 1367.2891920753918 1031.9477787217909 797.6528889501819 1049.4389937199344 1194.8586758683161 1270.6354445447225 1090.1966140521245 1146.426886858679 1226.414202302546 0.8607485716276875 1.1148673829024145 0.8414349546705738 0.6503943671335662 0.8556970326580143 0.9742700905004316 1.0360573468238974 0.8889301934088187 0.934779526122827 1.0 10.26023059377795 -6.761287107997324 24.99974206334003 0.9641936984424988 0.8653401923025495 0.17576397929552434 0.11055716273779195 8.84209138770065 1451733.150929354 0.04161300581208417 0.03911652318333096 1.7326581750261832e-07 6.761287107997324 -0.09885350613994925 GSYGS(ph)DAEEEEYR ddPTM_A459_Selumetinib_30min_R2 2 GSYGSDAEEEEYR 13 0 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;A0A3B3IS03 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 GSYGS(1)DAEEEEYR;GSYGS(1)DAEEEEYR 188.09 0.00014582 51344000.0 76221.0 65423.0 66975.0 79195.0 87415.0 71541.0 71982.0 74746.0 75259.0 57950.0 True False 71984.94195683826 70440.733731899 62665.90141686634 68408.504381005 76433.14619998478 81395.12336546202 75329.30562962712 74963.49848513356 90312.90291215449 56276.83292781789 1.279122122049192 1.2516826208441418 1.113529282951001 1.2155713252156086 1.3581636034497515 1.4463344707023844 1.3385491277777912 1.3320489904128696 1.6047971823146503 1.0 15.78025352035033 -6.266464065518511 5.860813249320325 1.3683692542327486 1.2097428483504122 0.15234362825751702 0.14688244229485126 0.25105027036362326 36.75673105562984 0.04266328762492365 0.05141433087447749 5.414220444812244e-07 6.266464065518511 -0.15862640588233634 GSYGS(ph)DAEEEEYRQQLSEHSK ddPTM_A459_Selumetinib_30min_R2 2 GSYGSDAEEEEYRQQLSEHSK 21 1 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;A0A3B3IS03 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 GS(0.25)Y(0.001)GS(0.749)DAEEEEYRQQLSEHSK;GS(0.087)Y(0.002)GS(0.911)DAEEEEYRQQLSEHSK 63.522 0.005301 21258000.0 63786.0 73611.0 84740.0 95594.0 97106.0 57181.0 42459.0 45257.0 45543.0 97259.0 True False 60241.02947558927 79256.7270033293 79287.92065793587 82573.93229115209 84906.67614134557 65057.163712563226 44433.42763091242 45388.69037730034 54652.87257774151 94450.8799607703 0.6378027340836854 0.8391316950805349 0.8394619583308034 0.8742526520181576 0.898950609847268 0.6887936220349075 0.4704395305725857 0.4805533881330943 0.5786380455157358 1.0 16.527276617233774 -6.975014493091536 5.88517193186985 0.5873366601422864 0.8219445357732024 0.2269931033805861 0.15451124755470233 0.19403032266021475 21.11763139734149 0.05370099608996612 0.04622804833176534 1.0592183768003608e-07 6.975014493091536 0.234607875630916 GT(ph)FSDQELDAQSLDDEDDNMHHAVYPAVNR ddPTM_A459_Selumetinib_30min_R2 2 GTFSDQELDAQSLDDEDDNMHHAVYPAVNR 30 0 Q9P270;D6RIF6 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 GT(0.535)FS(0.464)DQELDAQS(0.001)LDDEDDNMHHAVYPAVNR;GT(0.5)FS(0.5)DQELDAQSLDDEDDNMHHAVYPAVNR 67.899 0.00029844 18282700.0 17834.800000000003 15112.8 19557.2 21165.0 27391.0 24762.0 21711.0 23577.0 24029.0 19475.4 True False 16843.61321436112 16271.903164688925 18298.911044269353 18282.290488338516 23949.897701353093 28172.74073294435 22720.604519530352 23645.60516661753 28835.47142635643 18913.094598833886 0.8905794409445632 0.8603511751954221 0.9675260147748427 0.9666472291354021 1.2663130074350581 1.4895891619281267 1.2013160723539775 1.2502240203501882 1.5246300004301951 1.0 14.207097818835056 -6.239952636648488 3.429079961846125 1.3109637297335726 0.9104106947535272 0.6236517634552721 0.14013509375163685 0.1512640873408816 3.7649342979095515 0.04243709223851913 0.05348083203866881 5.755026971726897e-07 6.239952636648488 -0.40055303498004535 GT(ph)PAGTTPGASQAPK ddPTM_A459_Selumetinib_30min_R2 1 GTPAGTTPGASQAPK 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 GT(0.999)PAGT(0.001)TPGASQAPK 156.96 0.00036981 0.0 6266.0 5460.3 8088.3 6991.1 5631.3 6611.3 7225.8 5033.7 4662.6 5078.1 True False 5917.76080478541 5879.0874523682505 7567.9075838751805 6038.900119679825 4923.845749539253 7521.946563594015 7561.814017651067 5048.347233626105 5595.250283928985 4931.482058511681 1.1999964178256357 1.1921542819406619 1.5346111968131486 1.2245609023877018 0.9984515184518926 1.5252912764046707 1.5333755507838587 1.023697779638621 1.1345981223376138 1.0 12.267805569630891 -7.794326691575211 24.99511383288663 1.0593606483220226 1.311553675309533 0.3348957186607796 0.16952924737571776 255.71198287957793 194343.66046599875 0.09738199749172807 0.04678564466781515 1.6057329098527066e-08 7.794326691575211 0.25219302698751034 GT(ph)PDTDLEVQR ddPTM_A459_Selumetinib_30min_R2 1 GTPDTDLEVQR 11 0 P0C7T5 P0C7T5 ATXN1L Ataxin-1-like 1 GT(0.999)PDT(0.001)DLEVQR 171.49 0.00070757 13742000.0 20291.0 16272.0 22806.0 24612.0 33714.0 23459.0 20834.0 18917.0 21205.0 23551.0 True False 19163.307451308763 17520.01007727344 21338.68678929533 21259.803141931858 29478.54591301591 26690.264310400664 21802.822281787823 18972.04533812205 25446.592517203713 22871.021437153373 0.8378859468068389 0.7660353135261657 0.9330010401123229 0.929551974770828 1.2889037769484484 1.1669904811091223 0.9532946458774995 0.8295233070483884 1.1126128575904526 1.0 14.481233178591939 -5.67004456287345 2.2275987146059495 1.0498813737987878 0.8087127580941518 0.38507432089463245 0.12209662824967898 0.34725024890665884 3.4873464686723965 0.03967299777670909 0.08213530697792255 2.137742724877162e-06 5.67004456287345 -0.241168615704636 GT(ph)PGKGATPAPPGK ddPTM_A459_Selumetinib_30min_R1 1 GTPGKGATPAPPGK 14 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 GT(1)PGKGATPAPPGK 130.47 0.01004 5676500.0 1174.7 1464.0 1171.3 1498.2 1375.6 1322.1 1518.6 1157.2 850.67 1178.0 True False 1202.0682244316974 1292.594199404865 1012.2438934903562 1236.567494697091 1251.1772228819061 1308.800874370753 1404.050779368125 1126.507296884649 1443.5248595214146 1329.2077746916914 0.904349378117741 0.9724545883766601 0.7615392512469658 0.9303041392335459 0.941295444327442 0.9846473209760817 1.0563064752565063 0.8475027895062841 1.0860039242971167 1.0 10.376350921321329 -6.392346174220965 2.2503463116121716 0.9881864739422658 0.8866991802417319 0.2859375281004036 0.07677586180043416 0.4331143697824421 4.309364000687172 0.026040973684798956 0.030520192395361356 4.051854351667161e-07 6.392346174220965 -0.10148729370053389 GT(ph)PGPDSSGSLGSGEFTGVK ddPTM_A459_Selumetinib_30min_R1 1 GTPGPDSSGSLGSGEFTGVK 20 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 GT(0.997)PGPDS(0.003)SGSLGSGEFTGVK 193.42 3.8222000000000005e-15 19240000.0 1576.0 2257.9 1146.8 1231.6 2255.4 1453.9 2192.6 1940.4 840.75 1744.8 True False 1612.7177336378256 1993.5440183307685 991.0708589214888 1016.524179995286 2051.3994682232114 1439.2750860355786 2027.2104167276125 1888.9342886925115 1426.6913440495491 1968.7620757912264 0.8191531894425028 1.012587576144559 0.5033979834882725 0.5163265752093252 1.0419742910776935 0.7310558770577434 1.0296878640924125 0.9594528012905608 0.724664174301598 1.0 10.943073057244257 -6.275004674120796 24.81158928884042 0.9090350685185727 0.7193129508425916 0.2494205636281307 0.17103116321805048 1165.697757538292 2132113.7664879826 0.0554954542382558 0.0632709507866126 5.308787305855908e-07 6.275004674120796 -0.18972211767598113 GT(ph)PGPDSSGSLGSGEFTGVK ddPTM_A459_Selumetinib_30min_R2 2 GTPGPDSSGSLGSGEFTGVK 20 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 GT(1)PGPDSSGSLGSGEFTGVK;GT(0.999)PGPDS(0.001)SGSLGSGEFTGVK 225.69 2.2003e-20 15636900.0 26924.2 23509.4 34103.0 33530.0 34520.0 28957.0 33459.0 30269.0 31042.4 30123.0 True False 25427.860750112253 25312.49538536456 31908.85010853892 28963.156157523783 30183.288987284468 32945.56390452585 35014.909797750704 30357.07777869729 37251.74739712544 29253.270721046734 0.8692313756156426 0.8652877015612849 1.0907788880366662 0.9900826623357974 1.0317919413219192 1.1262181319377267 1.196957090085611 1.0377327741631435 1.273421620178836 1.0 14.836310316697976 -4.973610240451793 0.583268068287759 1.1325762722793562 0.6978867896097981 0.5313473231864827 0.08448962223709147 2.3381702275932965 0.70648532881606 0.0443436645439431 0.6663266908792104 1.0626488083671003e-05 4.973610240451793 -0.4346894826695581 GT(ph)PPLTPSDSPQTR ddPTM_A459_Selumetinib_30min_R1 2 GTPPLTPSDSPQTR 14 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 GT(0.999)PPLT(0.001)PSDSPQTR;GT(0.737)PPLT(0.247)PS(0.016)DSPQTR 119.87 0.0050277 32906000.0 2274.3 2810.3 2699.4 3012.1000000000004 2441.8 2568.6 2670.3 2721.5 1439.5 2377.6 True False 2327.2867649825553 2481.2687695269747 2332.8363067428218 2486.0932791196815 2220.939621134805 2542.7622161021995 2468.8771211291355 2649.3169793221336 2442.726363079781 2682.7881197852007 0.8674880986012757 0.9248843586371774 0.8695566711133349 0.9266826779144721 0.8278475682651472 0.9478058283282497 0.9202654145221159 0.9875237480678322 0.9105178098355974 1.0 11.389517403142102 -6.907261377066269 14.152574830256357 0.9507516381111428 0.8872533724121942 0.47263616455350177 0.036782383672788764 0.7777947040317748 115.37280960760522 0.012046034163588253 0.01062393932666725 1.2380512498653794e-07 6.907261377066269 -0.06349826569894867 GT(ph)PPPVFTPPLPK ddPTM_A459_Selumetinib_30min_R1 1 GTPPPVFTPPLPK 13 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 GT(1)PPPVFTPPLPK 115.37 0.009393899999999998 39362000.0 2203.1 2750.5 2807.5 2967.2 2624.2 2193.1 2314.8 2635.8 1512.1 1859.0 True False 2254.42794351364 2428.4701813272422 2426.256920493617 2449.0342212422943 2386.8415733401407 2171.039405175479 2140.192772343829 2565.890021714967 2565.9232605855755 2097.620758193426 1.0747547833457103 1.1577260435860486 1.1566709144236487 1.167529550647431 1.1378804123753075 1.0350009155350297 1.0202953817958342 1.2232382863739573 1.223254132360644 1.0 11.03453815241035 -6.553840110623456 24.99605777214614 1.1067656254619613 1.1431157746601046 0.057233203170384495 0.07538440671325071 764.3536790599074 617081.3660361215 0.026502345072715414 0.026502573985412593 2.793572130367329e-07 6.553840110623456 0.03635014919814328 GT(ph)PPPVFTPPLPK ddPTM_A459_Selumetinib_30min_R2 1 GTPPPVFTPPLPK 13 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 GT(1)PPPVFTPPLPK 130.19 0.0038591 32468000.0 108640.0 115180.0 132670.0 130350.0 129830.0 95873.0 90604.0 98013.0 79530.0 91673.0 True False 102602.22372037775 124013.93563792769 124134.15664017417 112596.10513370803 113519.5947050737 109078.63550155771 94817.26552841993 98298.20160307441 95438.22225386543 89026.1622949412 1.1524951887789956 1.39300552153504 1.3943559223514674 1.26475299205508 1.2751262300736546 1.225242475803722 1.0650494538256403 1.1041496012982701 1.072024445327445 1.0 16.441941745590768 -7.08853182047813 1.3461086267852678 1.0531136054350865 1.3146254963807391 0.7222208924529581 0.0689694442500674 0.2331116199598404 0.8472246983409771 0.03901567819425272 0.026363488427526897 8.155830276982275e-08 7.08853182047813 0.26151189094565264 GT(ph)PSQSPVVGR ddPTM_A459_Selumetinib_30min_R1 1 GTPSQSPVVGR 11 0 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 1 GT(0.997)PS(0.003)QSPVVGR 179.83 0.00011972 26460000.0 1173.2 1270.4 1135.9 977.03 1195.4 692.47 1169.3 1020.8 637.66 1049.3 True False 1200.5332773501893 1121.660977407063 981.6510190520744 806.4100516245478 1087.2762810650115 685.5043805124541 1081.0987595911695 993.7250679742916 1082.0624471562717 1183.987876047532 1.0139742996000014 0.9473584992706743 0.8291056343660274 0.6810965449380784 0.9183170732242888 0.5789792229974947 0.9130995185526445 0.8393034152440915 0.9139134521955457 1.0 10.20943859260897 -10.732994375760386 12.62999068450667 0.9999999977373437 0.8415500326974648 0.11770921540748358 0.12329768591289812 0.0 0.0 0.12040494309681227 0.029202488131449475 1.8492925676985975e-11 10.732994375760386 -0.15844996503987896 GT(ph)PSQSPVVGR ddPTM_A459_Selumetinib_30min_R2 3 GTPSQSPVVGR 11 0 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 1 GT(0.994)PS(0.006)QS(0.001)PVVGR;GT(0.964)PS(0.035)QS(0.001)PVVGR;GT(0.75)PS(0.201)QS(0.049)PVVGR 129.76 0.0059009 123621000.0 40145.9 42690.0 42515.4 38965.0 43998.0 42911.0 40801.4 40216.0 35689.3 31091.1 True False 37914.751594770925 45964.18573001493 39780.00545126753 33657.89978162584 38470.5778928894 48821.60074272576 42698.745946440315 40333.02190188279 42828.157242359775 30193.41915862083 1.2557289850343265 1.5223246326804702 1.317505819472901 1.1147429048960769 1.2741378407918824 1.6169616460541272 1.4141739205527826 1.3358216136434784 1.4184599967748759 1.0 14.881946519106382 -10.650441717482986 5.412627895590539 0.9999930827961611 1.3648600134643343 0.39829367760203516 0.13395501835860435 1.1832189738207577e-05 1.9073760533712698e-06 0.13724508436280058 0.03328619114890971 2.2364453105624437e-11 10.650441717482986 0.3648669306681732 GT(ph)SPRPPEGGLGYSQLGDDDLK ddPTM_A459_Selumetinib_30min_R2 2 GTSPRPPEGGLGYSQLGDDDLK 22 1 Q9UQ88-8;P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 Q9UQ88-8;P21127;Q5QPR4 CDK11A;CDK11B Cyclin-dependent kinase 11A;Cyclin-dependent kinase 11B 1 GT(0.541)S(0.459)PRPPEGGLGYSQLGDDDLK;GT(0.5)S(0.5)PRPPEGGLGYSQLGDDDLK 82.479 0.001259 69831000.0 77040.0 53711.0 64391.0 60988.0 73086.0 63060.0 80784.0 73311.0 60008.0 55801.0 True False 72758.42521555499 57830.46099191459 60248.1531636199 52681.3291898318 63904.2832828701 71745.9425983148 84540.6160704592 73524.32287271056 72011.2767636106 54189.880141590394 1.3426570611606383 1.0671819321395781 1.111797129024831 0.9721617588410055 1.1792660016205492 1.3239730815209947 1.5600812522479601 1.356790653173656 1.3288694600441162 1.0 15.72573583569121 -6.708740280172142 3.875152801031243 1.3535448405168575 1.1150064477120316 0.23425570951285635 0.15615392983025034 0.25762512972524965 7.921523544468644 0.05306614092224439 0.05129988394371376 1.9555085530859314e-07 6.708740280172142 -0.23853839280482592 GTAAFS(ph)PSHPLLPLR ddPTM_A459_Selumetinib_30min_R2 2 GTAAFSPSHPLLPLR 15 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 GT(0.002)AAFS(0.996)PS(0.001)HPLLPLR;GT(0.007)AAFS(0.839)PS(0.154)HPLLPLR 85.176 0.013883 8727900.0 39480.0 39295.0 40469.0 44253.0 45679.0 37115.0 34490.0 37494.0 29722.0 46066.0 True False 37285.859650962 42308.8001466605 37865.26859931565 38225.665059317 39940.39564455871 42227.25435357524 36093.85334063845 37603.10133253414 35667.230502066916 44735.95488615805 0.833465156736797 0.9457448768965799 0.8464169077350289 0.8544729883734877 0.892803020438418 0.9439220524303811 0.8068197813702287 0.8405565820205413 0.7972833170283546 1.0 15.449147190494605 -7.278153557243434 24.924592377880458 0.8478779773419963 0.8859051330837183 0.019500786632229983 0.06303324536667948 2226.7906721615554 3320634.3651406863 0.024942349777253795 0.016873424033825902 5.2704347716886654e-08 7.278153557243434 0.038027155741721996 GTAGKS(ph)PDLSSQK ddPTM_A459_Selumetinib_30min_R1 1 GTAGKSPDLSSQK 13 1 Q9Y2I7 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 GTAGKS(1)PDLSSQK 175.66 0.00047028 7691300.0 1883.8 2343.8 2113.2 1929.7 1857.9 1836.1 1901.4 2270.2 1110.3 1883.4 True False 1927.6888747632847 2069.3868063969408 1826.2390469767101 1592.7141199552639 1689.853273038886 1817.6305010454141 1757.9758671740774 2209.986921351132 1884.0980068964777 2125.1527358695535 0.9070825085776849 0.9737590957433961 0.8593448443269015 0.7494586591695347 0.7951679164121092 0.8552940550419733 0.8272233037663349 1.039919100424971 0.8865706332987672 1.0 11.053350816906779 -7.748418671685056 24.99628388736482 0.9724336592604381 0.8513467463422812 0.41376505873965863 0.06706464196567902 238.9659840964966 458752.9448182054 0.03468161340022989 0.019862420148691686 1.7847661821396052e-08 7.748418671685056 -0.12108691291815687 GTAT(ph)PELHTATDYR ddPTM_A459_Selumetinib_30min_R1 1 GTATPELHTATDYR 14 0 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GT(0.011)AT(0.989)PELHTATDYR 102.39 0.010334 8115700.0 2671.7 3681.0 2522.0 2229.1 2769.3 2548.8 3350.9 3255.2 1961.7 3182.7 True False 2733.9454117767636 3250.0268087495274 2179.526252354373 1839.829530389323 2518.8173039596263 2523.1613861252376 3098.1389151749336 3168.861521620211 3328.8616231008023 3591.230547123298 0.7612837371209014 0.9049897426810743 0.6069023483051652 0.5123117288760788 0.701380006353891 0.7025896424684789 0.8626956344132938 0.8823887745548892 0.9269417764803035 1.0 11.810262557691098 -7.46812670862843 1.6999948054516272 0.9427594292457196 0.6917531491099864 0.5566004214487947 0.09802322799556604 0.3342886693899691 1.8805494379208982 0.06858042284355813 0.035240486760777213 3.4030888757975175e-08 7.46812670862843 -0.25100628013573323 GTAT(ph)PELHTATDYR ddPTM_A459_Selumetinib_30min_R2 1 GTATPELHTATDYR 14 0 Q12802-4;Q12802;Q12802-2;H0YMW2 Q12802-4 AKAP13 A-kinase anchor protein 13 1 GT(0.063)AT(0.883)PELHT(0.02)AT(0.034)DYR 91.932 0.022166 6407800.0 43439.0 30633.0 37671.0 54069.0 51683.0 40864.0 43874.0 49219.0 34074.0 38641.0 True False 41024.83428009471 32982.452599380355 35247.288873083606 46704.708925772546 45190.11948811769 46492.64507354162 45914.227934681694 49362.219141355934 40889.7521071068 37525.33392862486 1.093257007602546 0.8789382837235958 0.9392931436699747 1.2446180762736805 1.2042562918712902 1.2389668580157889 1.2235528142671015 1.3154371719981346 1.0896572482174638 1.0 15.19557728963732 -5.759004178931811 24.999999260508098 1.2054866170793768 0.9613403072782172 0.5042791544173848 0.09766710503620948 43.65161189094382 448119.9015330288 0.025337363529267652 0.041382678302170954 1.7417901132036892e-06 5.759004178931811 -0.2441463098011596 GTDDS(ph)PKDSQEDLQER ddPTM_A459_Selumetinib_30min_R1 1 GTDDSPKDSQEDLQER 16 1 Q969E4;Q6IPX3-2;Q6IPX3;Q5H9L2 Q969E4 TCEAL3;TCEAL6;TCEAL5 Transcription elongation factor A protein-like 3;Transcription elongation factor A protein-like 6;Transcription elongation factor A protein-like 5 1 GT(0.011)DDS(0.971)PKDS(0.019)QEDLQER 71.279 0.0222 13853000.0 2128.3 3311.3 3252.0 3257.8 2054.9 2618.3 2547.3 2238.9 2034.4 2655.8 True False 2177.885249049104 2923.6114566183933 2810.3962619573426 2688.8863864798977 1869.0346578220624 2591.9622792261907 2355.1551101570035 2179.5170990278616 3452.2282133028843 2996.6977996826804 0.726761720611174 0.9756110399013119 0.9378310559893409 0.8972831317073825 0.6236980779376465 0.8649394942328362 0.7859167882748772 0.7273062700078233 1.1520107945714246 1.0 11.549157888072587 -8.264214805011589 24.99969605360314 1.0760054133126802 0.8234440764182928 0.4815703336726619 0.10717444875714414 227.40321510858104 2048278.8917616573 0.09176559377525496 0.02781974501948825 5.442334047096023e-09 8.264214805011589 -0.2525613368943874 GTDDS(ph)PKDSQEDLQER ddPTM_A459_Selumetinib_30min_R2 1 GTDDSPKDSQEDLQER 16 1 Q969E4;Q6IPX3-2;Q6IPX3;Q5H9L2 Q969E4 TCEAL3;TCEAL6;TCEAL5 Transcription elongation factor A protein-like 3;Transcription elongation factor A protein-like 6;Transcription elongation factor A protein-like 5 1 GTDDS(1)PKDSQEDLQER 75.911 0.016569 19500000.0 88312.0 78531.0 62094.0 64908.0 60042.0 53997.0 70000.0 59246.0 43502.0 59165.0 True False 83403.97258094624 84554.07518303611 58098.93964283545 56067.41842745462 52498.98717770957 61434.59661403748 73255.13870236852 59418.3960512967 52203.61554743675 57456.752720868746 1.4515956546679893 1.4716124942495297 1.0111768746327612 0.9758194776484556 0.9137130918754746 1.0692319649962387 1.274961344548135 1.0341412146968667 0.9085723274520522 1.0 15.810188838032786 -5.260755937674051 24.96103056694156 1.0296684202747024 1.4616041168002225 0.765145831589148 0.09704947489517986 28.441751713686017 1038712.2869111703 0.02761063151998734 0.06479216823366049 5.485851690631756e-06 5.260755937674051 0.4319356965255201 GTDS(ph)QAMEEEKPEGHV ddPTM_A459_Selumetinib_30min_R1 1 GTDSQAMEEEKPEGHV 16 1 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 1 GT(0.004)DS(0.996)QAMEEEKPEGHV 106.35 0.024802 0.0 984.67 1253.7 1203.0 1179.0 1333.1 1007.8 1349.7 1172.6 742.59 1067.7 True False 1007.61089516571 1106.916221170683 1039.6392076059913 973.109782570998 1212.5213403779203 997.6624470091862 1247.891042350296 1141.4988388583995 1260.1209933722919 1204.7496952787096 0.8363653455273188 0.9187935265794829 0.8629503802160985 0.8077277681700318 1.0064508379870665 0.82810765665177 1.0358093861659836 0.9474987570711296 1.0459608317898537 1.0 10.234517720834448 -7.2015319106595745 0.9571079244233434 1.015871590889365 0.8686317684870641 0.4757733715028887 0.06245364136314551 0.49740142545104016 0.8986088831026756 0.0431439518326545 0.026012858638056566 6.287356548053789e-08 7.2015319106595745 -0.14723982240230082 GTDTQTPAVLS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 7 GTDTQTPAVLSPSK 14 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GTDT(0.004)QT(0.272)PAVLS(0.554)PS(0.169)K;GTDTQTPAVLS(0.994)PS(0.006)K;GTDTQT(0.006)PAVLS(0.931)PS(0.063)K;GTDTQTPAVLS(0.997)PS(0.003)K;GTDTQTPAVLS(0.996)PS(0.004)K;GTDTQTPAVLS(0.998)PS(0.002)K;GTDTQT(0.022)PAVLS(0.971)PS(0.007)K 236.31 2.8806e-21 1243616700.0 43223.700000000004 83120.1 40572.9 50534.200000000004 40677.4 50162.2 48429.100000000006 39283.299999999996 22840.99 41672.2 True False 44230.72811132062 73388.36005051382 35063.32303098681 41709.35061441846 36998.13635217828 49657.61381163345 44776.053996507886 38241.37927385821 38759.49179009493 47021.23279160197 0.9406543700662026 1.5607493826410488 0.7456912749690634 0.8870322647488685 0.7868389269195463 1.0560678838795212 0.9522518091976722 0.8132789593872186 0.8242976521240295 1.0 15.521024743274873 -5.27927175337731 24.934056203918438 0.8818516453793995 1.2507019439650469 0.43812716734939805 0.16647345547115386 580.5099559687319 811695.4117049233 0.04084894714748214 0.08531796625388491 5.256882217897123e-06 5.27927175337731 0.36885029858564733 GTDTQTPAVLS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 8 GTDTQTPAVLSPSK 14 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GTDTQT(0.001)PAVLS(0.998)PS(0.001)K;GTDTQTPAVLS(0.959)PS(0.041)K;GTDTQT(0.003)PAVLS(0.882)PS(0.115)K;GTDTQTPAVLS(0.884)PS(0.116)K;GTDTQT(0.005)PAVLS(0.994)PSK;GTDTQT(0.002)PAVLS(0.499)PS(0.499)K;GTDTQTPAVLS(0.992)PS(0.008)K;GTDTQTPAVLS(0.996)PS(0.004)K 213.02 2.3286e-06 1903681100.0 743922.0 681447.9 748398.0 733883.3 692722.0 575694.1 676275.0 697931.1 545741.6 673873.5 True False 702577.7933957188 733712.7627296478 700246.8874741321 633927.1285206948 605696.0693467463 654990.7366442839 707723.1275134906 699961.963952286 654905.169294353 654417.0211213778 1.0735933979709376 1.121170047613359 1.0700315928125195 0.9686898538097732 0.9255506042750147 1.000876681847185 1.0814558678513129 1.0695962075571699 1.000745928295292 1.0 19.319850747117528 -5.582286466390782 6.139552507793122 1.0093415161611656 1.0971057547610856 0.4325426052227813 0.04346294052269 0.20539639329060447 15.386698283012992 0.01365328329625479 0.02406185698874368 2.6164565894861743e-06 5.582286466390782 0.08776423859992 GTDTQTPAVLS(ph)PSKTQATLKPK ddPTM_A459_Selumetinib_30min_R1 1 GTDTQTPAVLSPSKTQATLKPK 22 2 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GTDTQT(0.004)PAVLS(0.843)PS(0.148)KT(0.003)QATLKPK 77.668 0.0017362000000000002 131330000.0 1853.0 2370.7 3518.2 3954.5 2777.1 2785.9 2078.4 1754.1 1232.6 1807.4 True False 1896.1712946896528 2093.1373418914695 3040.447764089277 3263.92081015862 2525.9117953368263 2757.8763753948133 1921.6246146705603 1707.5755698801959 2091.632174457892 2039.397395566863 0.9297703815899011 1.0263508948483624 1.4908559610296874 1.600433940561836 1.2385579195244258 1.352299645664814 0.9422511859864531 0.8372941799337568 1.0256128496606762 1.0 10.993927209968302 -7.269176678014536 23.535218572396317 0.9377306681141688 1.2850456812072633 0.4045437595998467 0.19062110406565122 289.9497026711861 881958.3849272652 0.08712554869569028 0.0600847140576271 5.380508502045799e-08 7.269176678014536 0.3473150130930944 GTDTQTPAVLS(ph)PSKTQATLKPK ddPTM_A459_Selumetinib_30min_R2 1 GTDTQTPAVLSPSKTQATLKPK 22 2 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GT(0.001)DT(0.002)QT(0.003)PAVLS(0.961)PS(0.026)KT(0.003)QAT(0.003)LKPK 53.359 0.012582 278170000.0 74606.0 98171.0 83985.0 73275.0 80512.0 44749.0 58519.0 54241.0 42037.0 84993.0 True False 70459.69719148098 105700.40003048266 78581.4965359542 63294.818593574535 70397.36277358767 50912.76855902298 61240.249453198674 54398.83232991903 50445.574611916636 82539.03125166554 0.8536530671973351 1.2806111051654698 0.95205256645617 0.7668471223097536 0.8528978557907066 0.6168326401092286 0.7419550305415406 0.6590679767497432 0.6111723610870307 1.0 16.33278888529663 -5.679529548080323 3.0295251972932125 0.7302996600698031 1.07733264287511 0.44040207954447563 0.14622506675315003 0.19762810121506258 3.6306561434486144 0.03964125182232331 0.073846091252593 2.091560598817589e-06 5.679529548080323 0.3470329828053069 GTDTQTPAVLSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GTDTQTPAVLSPSK 14 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GTDTQTPAVLS(0.362)PS(0.637)K 119.45 0.0022113 11120000.0 3430.0 5912.1 3251.0 3549.3 3370.9 4247.3 3584.9 2850.8 2064.2 3137.4 True False 3509.912326381818 5219.908583539278 2809.532056464736 2929.4813836125904 3066.0026901807328 4204.576018239851 3314.488106780452 2775.187523296543 3502.796636796998 3540.1158508639355 0.9914682101505953 1.4745021924255397 0.793627150868267 0.8275100327289219 0.8660741115103622 1.1876944697201814 0.9362654349211705 0.7839256228349933 0.989458194127226 1.0 11.789580858171504 -5.274867489894709 24.992983450409962 0.9198262391099129 1.2329852274895587 0.38459597812956803 0.15676983837937225 670.7354898219148 1248402.3062592365 0.040513748993647423 0.08506201629863328 5.310464501732706e-06 5.274867489894709 0.31315898837964584 GTDTQTPAVLSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 GTDTQTPAVLSPSK 14 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GTDTQTPAVLS(0.325)PS(0.674)K 169.64 0.00017398 5717600.0 39319.0 32353.0 37454.0 29195.0 31313.0 29129.0 30847.0 31316.0 26925.0 32178.0 True False 37133.80738642796 34834.37106870869 35044.250416831856 25218.590635815868 27379.180998228225 33141.255343265315 32281.44662217092 31407.124375357107 32310.752347357244 31248.937531515512 1.1883222381233722 1.1147377741587905 1.121454141648453 0.8070223382917305 0.8761635806214365 1.060556228826703 1.0330414142757363 1.0050621511109636 1.033979229366466 1.0 14.93151951831389 -5.556045761921206 24.988285260953845 0.9750297134233729 1.1431716336471431 0.5131858801651203 0.07518557174932751 157.41582292484088 118597.61318779437 0.022395482490635405 0.03879036766454511 2.7794203828085726e-06 5.556045761921206 0.16814192022377028 GTDTQTPAVLSPS(ph)KTQATLKPK ddPTM_A459_Selumetinib_30min_R2 1 GTDTQTPAVLSPSKTQATLKPK 22 2 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 GTDTQT(0.002)PAVLS(0.203)PS(0.696)KT(0.086)QAT(0.013)LKPK 50.098 0.021285 250630000.0 181030.0 205900.0 205590.0 214210.0 179890.0 125400.0 134560.0 147020.0 95264.0 203050.0 True False 170969.0773205078 221691.86792715057 192362.5632294675 185034.2284671388 157290.6099629956 142672.71173213876 140817.30662558172 147447.80385952877 114319.46189855687 197187.41891274208 0.8670384665675033 1.1242698400816942 0.9755316251418167 0.9383673131246714 0.7976706162607599 0.7235386137655833 0.7141292654573219 0.7477546218340445 0.5797502828978388 1.0 17.58920798126818 -6.247902013293975 2.008136604153554 0.7344130880736827 1.002093950590573 0.46684495109884927 0.1136260367593856 0.2560730021113615 2.0282395564735984 0.036687776344584436 0.04820758985011349 5.650644518143636e-07 6.247902013293975 0.2676808625168904 GTDVNVFNT(ph)ILTTR ddPTM_A459_Selumetinib_30min_R2 1 GTDVNVFNTILTTR 14 0 P04083 P04083 ANXA1 Annexin A1 1 GTDVNVFNT(0.998)ILT(0.002)TR 141.85 0.00076379 0.0 11424.0 8669.0 8924.0 9306.8 8139.4 7804.0 8629.9 8806.8 6805.4 5648.6 True False 10789.099813895386 9333.884424771595 8349.83955571655 8039.197784874508 7116.855804840766 8878.930162341401 9031.207449822436 8832.426329955779 8166.670158763414 5485.510241174669 1.9668361445962779 1.70155263856965 1.5221627867982088 1.4655332742853455 1.2973917633807497 1.6186151829041273 1.64637509598168 1.6101376064634598 1.4887712901278989 1.0 12.421410105504894 -12.504511047866513 0.20572914988519336 8.54235070250262e-31 1.687483594051053 0.5749565524544928 0.15822035357871572 48.3553436294191 1.008723576697503 22.068677135450137 0.42211895870380695 3.1296008577215946e-13 12.504511047866513 1.687483594051053 GTDVNVFNTILTTR ddPTM_A459_Selumetinib_30min_R2 1 GTDVNVFNTILTTR 14 0 P04083 P04083 ANXA1 Annexin A1 0 122.66 0.024121 4155100.0 10942.0 9056.4 10292.0 10741.0 9311.2 9176.5 6418.8 8064.3 8922.2 10106.0 False True 10333.887444296515 9750.996759084264 9629.823925082332 9278.057270741514 8141.443812815856 10440.479579026893 6717.286918610905 8087.765777883264 10706.889307097155 9814.213521458621 1.0529511531109075 0.9935586522306515 0.9812119844373546 0.9453694124807036 0.8295564178438465 1.0638121492057362 0.6844447498440567 0.8240869999617894 1.0909574449024073 1.0 13.260656944187085 -5.492767186396109 1.2045428228505881 0.9009484507719083 1.044175173008473 0.11615852228119106 0.1149798665748868 1.2120835681871467 3.0436688261769005 0.03879002099649745 0.15908924475704225 3.2153837575605414e-06 5.492767186396109 0.14322672223656463 GTEAPAVVT(ph)EEEDDDEETAPPVIAPRPDHTK ddPTM_A459_Selumetinib_30min_R1 3 GTEAPAVVTEEEDDDEETAPPVIAPRPDHTK 31 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 GTEAPAVVT(1)EEEDDDEETAPPVIAPRPDHTK;GTEAPAVVT(1)EEEDDDEETAPPVIAPRPDHTK;GTEAPAVVT(0.989)EEEDDDEET(0.011)APPVIAPRPDHTK 145.19 6.036600000000001e-20 126390000.0 13752.3 15348.5 18236.6 18875.0 16852.8 15720.3 15954.400000000001 15363.6 8543.099999999999 12427.3 True False 14072.701832682415 13551.490484675927 15760.169886473339 15578.83557763154 15328.467215603507 15562.168054890368 14750.946763038872 14956.107419993941 14497.016736663321 14022.465007152861 1.003582595891944 0.9664128580647775 1.1239229249945766 1.1109912251294458 1.0931364212914387 1.1098025951180555 1.0519510482297094 1.0665819035643753 1.0338422473700872 1.0 13.775452362350212 -5.25122309047825 24.87486362726852 1.0786838678657897 0.9849977170432178 0.4696927476687355 0.03744517383499697 534.3543329726389 1301051.4315118187 0.009568659423777373 0.024697250543800574 5.607598482194975e-06 5.25122309047825 -0.09368615082257192 GTEAPAVVT(ph)EEEDDDEETAPPVIAPRPDHTK ddPTM_A459_Selumetinib_30min_R2 4 GTEAPAVVTEEEDDDEETAPPVIAPRPDHTK 31 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 GT(0.001)EAPAVVT(0.996)EEEDDDEET(0.003)APPVIAPRPDHTK;GTEAPAVVT(1)EEEDDDEETAPPVIAPRPDHTK;GTEAPAVVT(1)EEEDDDEETAPPVIAPRPDHTK;GTEAPAVVT(0.999)EEEDDDEETAPPVIAPRPDHTK 142.25 6.163e-19 157957900.0 563968.0 523014.0 608862.0 673016.0 630606.0 506600.0 474485.0 519823.0 409081.0 598562.0 True False 532624.9163027804 563127.4920449295 569688.4817988222 581350.0597826435 551383.6365908318 576379.551543074 496549.4926741912 521335.59886867035 490908.6306781525 581279.9598091551 0.9162967126505633 0.968771557563785 0.980058700089818 1.000120595888961 0.9485681164233861 0.9915696246130866 0.8542346666092144 0.8968752320995798 0.8445304579902029 1.0 19.148873645552065 -7.255482045101873 24.97682119740582 0.8903163579202321 0.968803405179012 0.35199881484992146 0.04501547451019751 451.6599978278574 1893642.5545042986 0.016509848651152743 0.012449752943504772 5.552875737219142e-08 7.255482045101873 0.07848704725877986 GTEAPAVVTEEEDDDEET(ph)APPVIAPRPDHTK ddPTM_A459_Selumetinib_30min_R1 1 GTEAPAVVTEEEDDDEETAPPVIAPRPDHTK 31 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 GTEAPAVVT(0.407)EEEDDDEET(0.592)APPVIAPRPDHTK 93.179 3.2222000000000004e-07 13656000.0 2527.9 3115.8 3234.6 2952.0 3087.1 2542.5 2623.9 2499.2 1384.4 2074.4 True False 2586.7951515628574 2751.000687503878 2795.3590863859868 2436.488615902957 2807.872350071771 2516.9247584052946 2425.9771104859897 2432.9130974542977 2349.225687424556 2340.669446367101 1.1051518425968956 1.1753050785422277 1.194256237558276 1.0409366515569187 1.1996022567089961 1.075301240126732 1.036445839993038 1.0394090892374257 1.0036554674863358 1.0 11.1927054934568 -7.037665536526026 3.3065202280424493 1.0236758524799408 1.1422468252928257 0.6187319333113429 0.045334623054452045 0.17199382620023643 3.820502697640861 0.01771506697887029 0.014048445260868613 9.16926371341811e-08 7.037665536526026 0.11857097281288498 GTEAS(ph)SGTEAATGLEGEEK ddPTM_A459_Selumetinib_30min_R2 1 GTEASSGTEAATGLEGEEK 19 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 GTEAS(0.655)S(0.345)GTEAATGLEGEEK 334.61 5.316099999999997e-155 9458700.0 60066.0 30566.0 40532.0 46457.0 55063.0 43623.0 76687.0 77011.0 67597.0 38018.0 True False 56727.772183249326 32910.31391481932 37924.21524790485 40129.47645720497 48145.49367053436 49631.6722798333 80253.09745240769 77235.08926014262 81118.28881798731 36920.321557373245 1.5364918232116642 0.8913875211968977 1.027190816552656 1.0869210983128839 1.3040377667273964 1.3442914413057572 2.1736835993613006 2.0919397773966093 2.1971176142637745 1.0 15.172127497733774 -7.104794135508308 3.880567337980293 1.953906176151178 1.1523239956346158 0.44689250868351926 0.36104504440127755 0.1881986690881932 5.035828937392908 0.13724991546516943 0.10560300232456743 7.85607940639237e-08 7.104794135508308 -0.8015821805165622 GTEASPPQNNSGS(ph)SSPVFTFR ddPTM_A459_Selumetinib_30min_R2 1 GTEASPPQNNSGSSSPVFTFR 21 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 GTEASPPQNNS(0.048)GS(0.74)S(0.101)S(0.101)PVFT(0.01)FR 111.93 9.8047e-05 5193600.0 30730.0 26272.0 35427.0 35081.0 38033.0 24720.0 25296.0 28616.0 22122.0 26482.0 True False 29022.149621936762 28286.977922205508 33147.665390001144 30302.907281899534 33254.954520666 28124.95561418238 26472.314123073065 28699.267822366168 26547.018140324482 25717.39585150083 1.12850265981511 1.0999161068073198 1.2889199816888417 1.1783038787004982 1.2930918321858504 1.0936160012694696 1.0293543823772568 1.1159476639113646 1.0322591872681866 1.0 14.650456942031175 -6.954323374051968 9.297809882640939 1.0550806214486836 1.1962272447054756 0.569184148239475 0.06331068212289391 0.2711564840574382 52.193715695505574 0.022746783622393647 0.020034361541596202 1.1109042440912054e-07 6.954323374051968 0.14114662325679195 GTEASPPQNNSGSS(ph)SPVFTFR ddPTM_A459_Selumetinib_30min_R1 1 GTEASPPQNNSGSSSPVFTFR 21 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 GTEAS(0.014)PPQNNS(0.044)GS(0.006)S(0.468)S(0.468)PVFTFR 179.84 2.9786e-14 5563400.0 1354.8 1476.9 1772.3 1813.5 1632.9 1388.1 1607.8 1289.7 771.2 1383.9 True False 1386.3642040181019 1303.983861407817 1531.631394547048 1496.8062686111157 1485.2044833119107 1374.1369742939585 1486.5223515527944 1255.492966463992 1308.670073780567 1561.5370453275316 0.8878202461903891 0.8350643139140558 0.9808485806532942 0.958546755640473 0.9511170341785838 0.8799899934527227 0.951960989975103 0.8040110032744391 0.8380653393375462 1.0 10.608751080390318 -10.181487438848302 9.207227660265684 0.9999999840851023 0.9007003364981909 0.21767324550270362 0.057545043029993435 0.0 0.0 0.0595908504157706 0.014452904152035548 6.584344736477006e-11 10.181487438848302 -0.09929964758691134 GTEASPPQNNSGSS(ph)SPVFTFR ddPTM_A459_Selumetinib_30min_R2 1 GTEASPPQNNSGSSSPVFTFR 21 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 GTEASPPQNNSGS(0.008)S(0.661)S(0.33)PVFT(0.001)FR 160.02 1.0886e-07 5159800.0 43948.0 35285.0 50599.0 50985.0 48385.0 31968.0 35897.0 38535.0 31153.0 36395.0 True False 41505.54609778313 37991.24604084276 47343.51542802573 44040.75504596928 42306.44373261179 36371.30182338924 37566.28162855608 38647.130470187316 37384.47048754761 35344.18178443367 1.1743247120821187 1.0748939181151143 1.339499545265377 1.246053885603479 1.1969846689517778 1.0290605125680952 1.0628703150542607 1.093450987376042 1.057726296100382 1.0 15.10918512353484 -6.733560258582348 8.489445264291104 1.0553490847215972 1.208978814650017 0.5902918051026509 0.06556983651644982 0.18305835054288622 48.72872464513452 0.023068489464052128 0.022731469412455997 1.8468845209553975e-07 6.733560258582348 0.15362972992841994 GTEASPPQNNSGSSS(ph)PVFTFR ddPTM_A459_Selumetinib_30min_R1 1 GTEASPPQNNSGSSSPVFTFR 21 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 GTEASPPQNNSGSS(0.03)S(0.969)PVFTFR 284.41 2.4664999999999997e-73 6615200.0 1105.7 1314.6 1084.0 1195.2 1219.1 1060.6 1323.3 1113.5 628.15 1185.5 True False 1131.4606586823252 1160.6860208590404 936.798753985781 986.4807566826603 1108.8326202495869 1049.9313269477511 1223.4824156050586 1083.9663628422543 1065.9246717391898 1337.670472747879 0.8458440862180713 0.8676920396356866 0.7003210230553893 0.737461711819208 0.8289280826927372 0.7848953448086161 0.9146366317645838 0.8103388576825958 0.796851461892209 1.0 10.385507044972877 -7.237233565398712 24.24581632157258 0.8646516468078478 0.7922649784817224 0.252766663818078 0.07055492069660892 911.030054764482 912536.2339558251 0.027488416849870176 0.0212803280926341 5.791171610172994e-08 7.237233565398712 -0.07238666832612539 GTEASS(ph)GTEAATGLEGEEK ddPTM_A459_Selumetinib_30min_R1 1 GTEASSGTEAATGLEGEEK 19 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 GTEAS(0.046)S(0.947)GT(0.007)EAATGLEGEEK 189.56 2.7522e-15 5292500.0 1122.5 1217.8 912.5 733.83 1221.3 772.3 1211.5 1357.5 798.18 1538.3 True False 1148.6520659952162 1075.219409860139 788.5875120037132 605.6803661951444 1110.8336306380272 764.5313631922951 1120.1155796157536 1321.4946902185543 1354.4531632393328 1735.7557893108915 0.6617590291611471 0.6194531606816702 0.4543193903543243 0.3489433075349869 0.6399711511715809 0.44046021214529263 0.6453186482301454 0.7613367608257829 0.7803247274647208 1.0 10.76134826796652 -8.15381338527058 0.9536346928905254 0.9817176817653295 0.5214452292288002 0.7012622716016832 0.09833891846075074 0.2991109991029158 0.5420123292932673 0.09615826197420496 0.03479456650210739 7.017567759294225e-09 8.15381338527058 -0.46027245253652926 GTEASS(ph)GTEAATGLEGEEK ddPTM_A459_Selumetinib_30min_R2 1 GTEASSGTEAATGLEGEEK 19 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 GTEAS(0.006)S(0.968)GT(0.026)EAATGLEGEEK 311.1 7.979799999999995e-117 10190000.0 52301.0 32401.0 39306.0 57835.0 51039.0 50496.0 85197.0 88912.0 69081.0 43824.0 True False 49394.319797491495 34886.052514364375 36777.09475313699 49957.77322906018 44627.02452555078 57451.3656429512 89158.8293146528 89170.71919982598 82899.13028441179 42558.68725157359 1.1606166211262816 0.8197163673810094 0.8641501213545343 1.1738560668882712 1.0485996492737384 1.3499327482387737 2.094961923698814 2.09524129991883 1.9478779924384682 1.0 15.37716603027451 -7.021848173436623 3.2574114386480417 1.872616653310994 1.0059442173765123 0.564792362527647 0.31396544526279724 0.1604711328622723 3.5023196308437226 0.11999825419168023 0.09612043623465513 9.50937177086909e-08 7.021848173436623 -0.8666724359344817 GTEDITSPHGIPLDLLDR ddPTM_A459_Selumetinib_30min_R2 2 GTEDITSPHGIPLDLLDR 18 0 Q9Y265;H7C4G5;Q9Y265-2;J3QLR1;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 ; 80.545 0.015701 3230100.0 16281.4 13069.3 17012.5 18905.8 20086.5 13852.7 13939.2 12690.6 15247.8 16801.0 False True 15376.544967608239 14071.673285577048 15917.934271809474 16330.797425675897 17563.054294411642 15760.78368270972 14587.400420000806 12727.527544958079 18297.78605912845 16315.911475759583 0.9424263542035667 0.8624509459053648 0.9756080311822369 1.0009123578500918 1.0764372140964928 0.9659762929043461 0.8940597919811705 0.7800684358864819 1.1214688242402715 1.0 13.99399196427174 -4.493413507264402 0.005536375428151899 1.8842084275971365 8.524113484646062e-05 0.02680493835085207 0.09342868352910746 155792.53820188576 123.8962901909684 20170.791386685687 22023.477961008128 3.210602154062725e-05 4.493413507264402 -1.88412318646229 GTENGVNGTLTSNVADS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 GTENGVNGTLTSNVADSPR 19 0 G3XAN4;Q15629-2;Q15629 G3XAN4 TRAM1 Translocating chain-associated membrane protein 1 1 GTENGVNGTLTSNVADS(1)PR 305.87 5.4171999999999975e-101 5337200.0 1869.5 2455.5 2072.5 2025.4 2816.0 2087.0 2948.1 2959.1 1121.8 2523.4 True False 1913.0557125862404 2168.0089184690187 1791.0658834276119 1671.7019114667523 2561.2932972051785 2066.006674844385 2725.7224434710743 2880.615055488563 1903.6126669697085 2847.3029699974677 0.6718834394317869 0.7614254406059735 0.6290394462058967 0.5871176791095888 0.8995506710012867 0.7256012783375219 0.9572997577681375 1.0116995226156509 0.668566951612951 1.0 11.47538029725663 -6.270833683955206 24.935386409112393 0.8741377632370086 0.6670616351183798 0.47249639905206087 0.11109150790210807 600.9541033766181 1595115.382243626 0.034137048211289586 0.03923391598195689 5.360018838050141e-07 6.270833683955206 -0.20707612811862885 GTENGVNGTLTSNVADS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 GTENGVNGTLTSNVADSPR 19 0 G3XAN4;Q15629-2;Q15629 G3XAN4 TRAM1 Translocating chain-associated membrane protein 1 1 GTENGVNGTLTSNVADS(1)PR;GTENGVNGTLTSNVADS(1)PR 346.44 1.709599999999999e-174 20171500.0 66297.0 28998.6 57155.0 64270.0 45248.0 38457.0 92256.0 71689.0 58517.0 47468.0 True False 62612.47814791859 31222.69937480467 53477.709525658785 55516.315128065966 39563.541717747634 43754.10267211215 96546.086801796 71897.6031212471 70222.0351015897 46097.47550332456 1.3582626264078814 0.677319072983788 1.160100611622473 1.2043244130378055 0.8582583164428235 0.9491648337435875 2.0943898933214484 1.5596863458620815 1.523337977510835 1.0 15.492400124161534 -7.22709879785582 24.957006020850717 1.5909942516846678 1.0237404687671792 0.3992586935318123 0.3040234389770515 533.9452715286815 388045.0644687106 0.1109048101400638 0.08590179709315895 5.927904550605643e-08 7.22709879785582 -0.5672537829174886 GTENTFPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 GTENTFPSPK 10 0 A6NIZ0;Q9GZM8-3;Q9GZM8;Q9GZM8-2;J3QSD2;J3QRZ1 A6NIZ0 NDEL1 Nuclear distribution protein nudE-like 1 1 GTENT(0.015)FPS(0.985)PK;GTENT(0.002)FPS(0.998)PK 118.76 0.005612300000000001 21425000.0 9594.599999999999 12126.9 12525.599999999999 13522.1 9225.0 10241.3 9390.6 10134.099999999999 7037.9 10323.4 True False 9818.135512158307 10707.07691035714 10824.692318195848 11160.71907625386 8390.600378806035 10138.2818203564 8682.259481584566 9865.310747803946 11942.8022721217 11648.508948431418 0.8428662892069472 0.919180039072636 0.9292770745266496 0.9581242651452619 0.7203153996749008 0.8703501765967752 0.7453537203792692 0.8469161839921497 1.025264463030688 1.0 13.507857676027783 -8.260361505222448 24.949497366844334 1.0126322484598638 0.8546583343714232 0.44006060047050644 0.07155145275983828 89.52556426990965 2072384.5168944392 0.05842309271168681 0.01924567406734626 5.4908362826892175e-09 8.260361505222448 -0.15797391408844053 GTENTFPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 GTENTFPSPK 10 0 A6NIZ0;Q9GZM8-3;Q9GZM8;Q9GZM8-2;J3QSD2;J3QRZ1 A6NIZ0 NDEL1 Nuclear distribution protein nudE-like 1 1 GTENT(0.011)FPS(0.989)PK;GTENT(0.001)FPS(0.999)PK 142.97 0.0011413 13766900.0 110841.0 103367.0 99804.0 106019.0 91311.0 73728.0 91381.0 85386.0 65585.0 91787.0 True False 104680.90095167876 111294.91652270925 93382.71929837916 91579.029307024 79839.69584930276 83883.36276385271 95630.39756801628 85634.45912358667 78703.83259801031 89136.87081873363 1.1743838435225649 1.248584513910474 1.0476329092624284 1.0273978485654571 0.8956977636298524 0.9410624581430022 1.072848942190126 0.9607074865543646 0.8829548521852459 1.0 16.443734695071086 -5.4928530804159355 2.1244317403495887 0.9647036785703126 1.2155099329011592 0.73685280202115 0.057079774099632885 0.16426124137201392 1.443578003673518 0.016892295542492674 0.04408436168191552 3.2147478873432026e-06 5.4928530804159355 0.2508062543308466 GTEPS(ph)PGGT(ph)PQPSRPVSPAGPPEGVPEEAQPPR ddPTM_A459_Selumetinib_30min_R1 1 GTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPR 33 1 I3L1Q2;Q8WUZ0;Q8WUZ0-2 I3L1Q2 BCL7C B-cell CLL/lymphoma 7 protein family member C 2 GT(0.005)EPS(0.663)PGGT(0.567)PQPS(0.383)RPVS(0.382)PAGPPEGVPEEAQPPR 74.058 5.0254e-05 8031300.0 1125.1 1527.8 1908.4 1731.8 1608.1 1401.8 1754.2 1415.2 794.46 1651.8 True False 1151.312640936497 1348.924465745049 1649.249762090835 1429.3736399121744 1462.6476389331144 1387.699164732564 1621.8792816854773 1377.66429878254 1348.140594937382 1863.824619894513 0.6177151158147368 0.7237400189624034 0.8848739009489947 0.7669035083317404 0.7847560458858495 0.7445438534936316 0.8701887851321928 0.7391598351461371 0.7233194478425137 1.0 10.864050397920224 -12.012390909411385 2.27934615106132 4.041234206519217 0.7670519835179708 0.4934353017492883 0.0722545584841754 4148399.984128516 402963.16728374705 65244143.81172892 0.019288929875038975 9.718720458108665e-13 12.012390909411385 -3.2741822230012465 GTEPS(ph)PGGTPQPSRPVS(ph)PAGPPEGVPEEAQPPR ddPTM_A459_Selumetinib_30min_R1 2 GTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPR 33 1 I3L1Q2;Q8WUZ0;Q8WUZ0-2 I3L1Q2 BCL7C B-cell CLL/lymphoma 7 protein family member C 2 GT(0.018)EPS(0.685)PGGT(0.247)PQPS(0.13)RPVS(0.92)PAGPPEGVPEEAQPPR;GT(0.002)EPS(0.532)PGGT(0.407)PQPS(0.183)RPVS(0.875)PAGPPEGVPEEAQPPR 63.202 0.00061068 10281000.0 2075.7 2478.3 2529.2 2765.7 2360.3999999999996 1905.06 2208.4 2187.22 951.7 1853.56 True False 2124.059771390887 2188.1394838695874 2185.7485319011425 2282.722413618838 2146.902236762468 1885.8968260560835 2041.8186100069595 2129.207820508159 1614.9653905821642 2091.4824812033394 1.0155761716774239 1.0462145887115613 1.045071403439902 1.0914375014537383 1.0264978339800592 0.9017033816946094 0.9762542255827046 1.0180376071250257 0.77216300164895 1.0 11.030310198308909 -6.644153315549771 5.559630833190014 0.9378393422347543 1.0500331903880775 0.4174184068332125 0.06600769592731535 0.2136328878232706 9.571666740970196 0.021404251839911004 0.021325437922718685 2.2690636808522527e-07 6.644153315549771 0.11219384815332323 GTEPS(ph)PGGTPQPSRPVS(ph)PAGPPEGVPEEAQPPR ddPTM_A459_Selumetinib_30min_R2 1 GTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPR 33 1 I3L1Q2;Q8WUZ0;Q8WUZ0-2 I3L1Q2 BCL7C B-cell CLL/lymphoma 7 protein family member C 2 GT(0.003)EPS(0.486)PGGT(0.486)PQPS(0.03)RPVS(0.995)PAGPPEGVPEEAQPPR 83.33200000000002 2.4941e-06 13378000.0 46531.0 40699.0 43392.0 51929.0 53497.0 41069.0 41527.0 39835.0 32813.0 39875.0 True False 43944.99329835142 43820.482432088975 40600.20596163743 44856.18061747845 46776.22859075194 46725.8819627369 43458.08778418943 39950.91325496074 39376.51687182295 38723.7051423078 1.1348344156855763 1.1316190501670942 1.0484587105607166 1.158364894387923 1.2079481655707143 1.2066480154990715 1.1222605797787943 1.0316913918268669 1.016858193892245 1.0 15.240929377996089 -7.751666855982902 3.488194446582374 1.0132998528102635 1.1471937683539901 0.6649309317605794 0.0421539670108262 0.16260247451289694 4.144308604440897 0.027422477610601407 0.013270641122929886 1.7714673164572862e-08 7.751666855982902 0.13389391554372665 GTEPSPGGT(ph)PQPSRPVS(ph)PAGPPEGVPEEAQPPR ddPTM_A459_Selumetinib_30min_R2 1 GTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPR 33 1 I3L1Q2;Q8WUZ0;Q8WUZ0-2 I3L1Q2 BCL7C B-cell CLL/lymphoma 7 protein family member C 2 GT(0.001)EPS(0.031)PGGT(0.926)PQPS(0.122)RPVS(0.921)PAGPPEGVPEEAQPPR 80.009 1.9254e-05 11978000.0 10072.0 11372.0 15395.0 16418.0 18147.0 8896.4 11340.0 10129.0 10359.0 12128.0 True False 9512.238561410573 12244.195833256732 14404.50246080863 14181.840077370276 15867.211623761634 10121.798346521531 11867.332469783712 10158.473713053781 12431.089454643397 11777.833127671705 0.8076391012079991 1.0395966474078597 1.2230180462453348 1.2041128383836939 1.3472097500245646 0.85939393407949 1.0075989650338764 0.8625078656605109 1.055464899178855 1.0 13.523786517740225 -6.791932077503663 24.999989321494787 0.9515627555737329 1.1295257126441978 0.2527450867766221 0.1435606450118067 298.70423288182695 244895.97020780883 0.053216745972616816 0.04693817974516678 1.6146110579352066e-07 6.791932077503663 0.17796295707046483 GTEPSPGGTPQPSRPVS(ph)PAGPPEGVPEEAQPPR ddPTM_A459_Selumetinib_30min_R1 2 GTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPR 33 1 I3L1Q2;Q8WUZ0;Q8WUZ0-2 I3L1Q2 BCL7C B-cell CLL/lymphoma 7 protein family member C 1 GTEPSPGGT(0.002)PQPS(0.008)RPVS(0.99)PAGPPEGVPEEAQPPR;GTEPS(0.002)PGGT(0.019)PQPS(0.158)RPVS(0.82)PAGPPEGVPEEAQPPR 91.66 4.9441e-09 78392000.0 2688.95 3608.48 3531.08 3639.12 3176.07 2825.66 3327.14 3394.3900000000003 1991.29 3139.54 True False 2751.5973032141055 3185.9974840631603 3051.5787308340527 3003.6160067428073 2888.7950292807022 2797.236425894004 3076.1711511042167 3304.3597506673746 3379.07369193271 3542.5305407092987 0.7767321330314263 0.8993563915542837 0.8614121164988049 0.8478730027099249 0.8154608678976405 0.7896153311169283 0.8683541654063748 0.9327681759394976 0.9538587326493844 1.0 11.790564575558358 -7.866353187872444 1.9489993171396578 0.9780818360972497 0.835602184746105 0.7457087796581059 0.03465522258724538 0.18765292710963122 1.3534177023670613 0.028074478840318134 0.01044528648615363 1.3603379442937236e-08 7.866353187872444 -0.1424796513511447 GTEPSPGGTPQPSRPVS(ph)PAGPPEGVPEEAQPPR ddPTM_A459_Selumetinib_30min_R2 2 GTEPSPGGTPQPSRPVSPAGPPEGVPEEAQPPR 33 1 I3L1Q2;Q8WUZ0;Q8WUZ0-2 I3L1Q2 BCL7C B-cell CLL/lymphoma 7 protein family member C 1 GTEPS(0.009)PGGT(0.151)PQPS(0.112)RPVS(0.728)PAGPPEGVPEEAQPPR;GTEPS(0.006)PGGT(0.065)PQPS(0.184)RPVS(0.744)PAGPPEGVPEEAQPPR 113.65 5.9698999999999994e-15 79554000.0 49427.0 52635.0 63763.0 64362.0 78588.0 49176.0 49263.0 54250.0 51791.0 65044.0 True False 46680.04521195794 56671.935251799885 59660.557999905235 55595.78456935714 68715.07285436596 55949.54762471814 51553.82711278259 54407.858518429 62150.64716144769 63166.01071539231 0.7390057514045753 0.8971903498409478 0.9445041300568809 0.8801534866568603 1.0878488616920279 0.8857540153487062 0.8161640497619701 0.8613470741974667 0.9839254760203308 1.0 15.946860840435544 -4.764508882760805 3.5276472841146442 0.9253106261735657 0.7129287801452485 0.37327150160877587 0.07444911068447681 0.35746479658131686 7.224732342475918 0.01945807076477622 0.20888039581009216 1.719852164204534e-05 4.764508882760805 -0.21238184602831722 GTGIVSAPVPK ddPTM_A459_Selumetinib_30min_R2 1 GTGIVSAPVPK 11 0 P15880;H0YEN5;E9PQD7;E9PMM9;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 130.41 0.033226 3601200.0 44239.0 39176.0 46728.0 44399.0 44269.0 36182.0 38578.0 37543.0 32144.0 39003.0 False True 41780.37348274843 42180.67322930583 43721.571353599604 38351.77960745295 38707.532450118655 41165.74207250598 40371.95344085678 37652.24391442177 38573.69817840113 37876.88204803589 1.1030573590973536 1.1136258041464928 1.154307561487015 1.0125379264009848 1.0219302740132972 1.0868302734184698 1.0658731991101222 0.9940692548734811 1.0183968714605793 1.0 15.209029955366965 -5.535822527148111 0.3155999955143591 0.9980080586756803 1.1827939547788329 0.5158081991642884 0.03660357749043302 4.037387304645895 0.47095522868861245 0.04545359096029371 0.27631133880187964 2.911906815039008e-06 5.535822527148111 0.18478589610315255 GTGQS(ph)DDSDIWDDTALIK ddPTM_A459_Selumetinib_30min_R1 1 GTGQSDDSDIWDDTALIK 18 0 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 GTGQS(0.966)DDS(0.034)DIWDDTALIK 247.18 8.8932e-33 12760000.0 3456.4 4175.5 3789.9 3965.1 3706.3 3219.8 3580.1 3681.6 1879.7 3141.8 True False 3536.9273950163592 3686.6305188627116 3275.2523964305474 3272.669719145264 3371.0658194004127 3187.4117353444926 3310.050174644952 3583.9520084778137 3189.7136121438425 3545.0806337235617 0.9977001260198026 1.0399285375324379 0.9238865726420442 0.9231580483707723 0.9509137217732695 0.8991083884026093 0.9337023657959096 1.010964877465544 0.8997577041833148 1.0 11.79160272695061 -5.263313216243069 24.999237495346684 0.940797228915676 1.0188143348334726 0.40658283245281257 0.036731568988656337 140.87548641495204 1879480.7552217683 0.009225997161413235 0.02093195755953798 5.4536439857409814e-06 5.263313216243069 0.07801710591779665 GTGQS(ph)DDSDIWDDTALIK ddPTM_A459_Selumetinib_30min_R2 2 GTGQSDDSDIWDDTALIK 18 0 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 GT(0.001)GQS(0.71)DDS(0.288)DIWDDT(0.001)ALIK;GT(0.105)GQS(0.598)DDS(0.297)DIWDDTALIK 141.6 0.00030841 4767600.0 11766.8 12233.900000000001 14021.2 13847.6 13859.6 9792.5 10040.55 13092.8 12738.2 8402.09 True False 11112.84836223252 13172.200791811434 13119.091257128295 11961.532991557602 12118.43314160394 11141.32798753564 10507.455469972383 13130.897880370274 15286.195935045713 8159.49983044848 1.361952153091927 1.6143392445033529 1.6078303241299554 1.4659639978079573 1.485193136028028 1.3654425171944966 1.2877572998729814 1.6092773029261214 1.8734231573855575 1.0 12.994265003740281 -5.947981287253879 18.26358080319347 1.4580414214361697 1.5367131032455885 0.02748842784790817 0.2202611050252954 37.93477447687626 13313.139269552352 0.06200415536391797 0.09196827988482734 1.127246025556736e-06 5.947981287253879 0.07867168180941886 GTGQSDDS(ph)DIWDDTALIK ddPTM_A459_Selumetinib_30min_R1 1 GTGQSDDSDIWDDTALIK 18 0 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 GT(0.005)GQS(0.338)DDS(0.653)DIWDDT(0.003)ALIK 224.99 3.969100000000001e-15 21177000.0 1411.8 1689.7 1519.4 1680.6 1509.8 1098.7 1258.5 1490.9 868.69 1336.6 True False 1444.6921931154077 1491.8691384797812 1313.0738254667858 1387.1147587691428 1373.2388565768401 1087.648075539783 1163.5703317758375 1451.3564888742853 1474.1034833926876 1508.165629586516 0.9579134842845408 0.9891944950958718 0.8706429848999959 0.9197363549184178 0.9105358387946636 0.7211728302268606 0.7715136248628383 0.9623322932191436 0.9774148505140202 1.0 10.558579161452668 -3.9271294134346526 14.919084991686134 0.8996249636829857 0.9044282150783414 0.0 0.09005555262932924 0.0 2.88911355315634e-09 0.022849581524540065 13011410.721425941 0.00011826890790792427 3.9271294134346526 0.0048032513953556455 GTGQSDDS(ph)DIWDDTALIK ddPTM_A459_Selumetinib_30min_R2 1 GTGQSDDSDIWDDTALIK 18 0 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 GTGQS(0.036)DDS(0.876)DIWDDT(0.088)ALIK 135.95 0.00035546 4152100.0 6931.2 7042.2 8717.1 8311.4 9402.2 5988.0 6849.7 6877.0 7430.1 7221.5 True False 6545.991651791994 7582.314095758053 8156.251276460858 7179.3729820352855 8221.011579265529 6812.792646348063 7168.224622423057 6897.010931451367 8916.3276143398 7012.9965312896775 0.9334086538594363 1.0811803573448622 1.163019436851331 1.0237240172589979 1.1722537637921375 0.9714524477449302 1.0221343459163001 0.9834613350625768 1.271400545338656 1.0 12.775815299099317 GTGQSDDSDIWDDT(ph)ALIK ddPTM_A459_Selumetinib_30min_R1 1 GTGQSDDSDIWDDTALIK 18 0 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 GTGQSDDS(0.049)DIWDDT(0.951)ALIK 227.41 2.6468999999999998e-18 21089000.0 5546.9 6366.6 5818.7 6238.4 6233.6 4868.3 5618.1 5323.3 2955.0 5045.6 True False 5676.131977611461 5621.1955122479585 5028.552499831243 5148.980549271345 5669.771980631467 4819.329322062736 5194.322193841741 5182.108791484663 5014.419175339181 5693.2519083059415 0.9969929434055949 0.9873435433354251 0.8832478486495632 0.9044006188729232 0.9958758319405788 0.8464985213515265 0.91236472186725 0.9102194799995471 0.8807653791014578 1.0 12.475037220474649 -5.21574937353402 9.297017808563918 0.9132097998529005 0.9924670174744613 0.3015674705315492 0.04571679251654264 0.5561129879742879 108.58891055262212 0.01112312747933073 0.02941474229345211 6.0848605043876004e-06 5.21574937353402 0.0792572176215608 GTGS(ph)ADSIATLPK ddPTM_A459_Selumetinib_30min_R1 1 GTGSADSIATLPK 13 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 GT(0.147)GS(0.852)ADS(0.001)IATLPK 128.21 0.0018489 7275800.0 2583.9 3340.7 3268.6 3244.7 3093.5 2711.3 2716.0 2849.2 1451.5 2741.2 True False 2644.0998426058245 2949.5692909507034 2824.7420731346187 2678.074055562442 2813.693471201785 2684.0267836634325 2511.129933335856 2773.629960494075 2463.089486634455 3093.0597215491225 0.8548492692153898 0.9536089039604597 0.9132517078331355 0.8658332837560473 0.9096796455622848 0.8677578272944466 0.8118595046325799 0.8967269339063829 0.79632781400058 1.0 11.594818974264806 -6.804565412672607 7.537284928749699 0.8639825707459964 0.9013390580015151 0.028623422095066076 0.05765742492429013 0.5636419038831548 81.4252186362215 0.01906486252771675 0.01694944744426467 1.5683196623351753e-07 6.804565412672607 0.03735648725551877 GTGS(ph)ADSIATLPK ddPTM_A459_Selumetinib_30min_R2 2 GTGSADSIATLPK 13 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 GT(0.012)GS(0.988)ADSIATLPK;GT(0.124)GS(0.876)ADSIATLPK 167.98 0.00029176 12907000.0 97127.0 84941.0 102771.0 120244.0 121293.0 87837.0 109811.0 108820.0 90528.0 110300.0 True False 91729.07017018707 91455.70157163718 96158.82574860437 103866.55976753002 106055.08896682187 99935.7494451026 114917.42908636844 109136.64818387908 108636.1295636602 107115.35240618313 0.8563578246220857 0.8538057292183076 0.8977128262993391 0.9696701493700582 0.9901016668895349 0.9329731658459625 1.0728380806758653 1.0188702714624058 1.0141975648057457 1.0 16.70880574493524 -5.700090447037562 0.7428781967173814 1.0204850568262236 0.8211205098361131 0.7972167615668403 0.03131546910426069 0.45678148527215184 0.42028506176624386 0.015705274846962776 0.0626479569378105 1.994846820915163e-06 5.700090447037562 -0.19936454699011052 GTHDLWDSR ddPTM_A459_Selumetinib_30min_R2 2 GTHDLWDSR 9 0 E9PGM4;Q04446 E9PGM4 GBE1 1,4-alpha-glucan-branching enzyme 0 ; 125.97 0.0069081 4971200.0 17164.5 10602.8 16945.0 19387.9 20705.2 17704.6 16856.2 20559.7 16899.5 17285.4 False True 16210.565804937636 11416.000666624566 15854.777148321024 16747.234574007012 18104.027669163464 20143.24794364294 17640.046699926654 20619.52532315845 20279.872211482394 16786.325589137243 0.9657006662272658 0.6800774002627521 0.9445055181451358 0.9976712583749998 1.0784985417463206 1.1999795808010554 1.050858128913088 1.2283525190588311 1.208118602477596 1.0 14.03499884839082 -5.929373542704836 1.451197321383551 1.1452779883023119 0.8225360511408192 0.6110042696077749 0.0962787938694118 0.2471416832379012 1.0570425000782238 0.03185389267401415 0.06082348170220054 1.1765935337660969e-06 5.929373542704836 -0.3227419371614927 GTHEMAGASGDKELGLGCS(ph)PPAETLADAK ddPTM_A459_Selumetinib_30min_R2 2 GTHEMAGASGDKELGLGCSPPAETLADAK 29 1 O60303 O60303 KIAA0556 Uncharacterized protein KIAA0556 1 GTHEMAGAS(0.001)GDKELGLGCS(0.98)PPAET(0.018)LADAK;GTHEMAGAS(0.001)GDKELGLGCS(0.988)PPAET(0.011)LADAK 77.675 1.9893e-05 8943200.0 73365.0 63549.0 79610.0 85812.0 85746.0 64806.0 61442.0 70264.0 62862.0 80136.0 True False 69287.66700336449 68423.00395775873 74487.9792728144 74124.2575660431 74973.82090103395 73732.43824970479 64299.17474501325 70468.45660716855 75436.15651103333 77822.2654616671 0.8903321766891186 0.8792214355602618 0.957155112755037 0.9524813641226426 0.9633980770961208 0.9474465670242298 0.8262310839137044 0.9055050786446096 0.9693389939694174 1.0 16.247895358353404 -5.2484218472921755 24.382007214097225 0.9342761073046209 0.8847767951593993 0.18818641595431818 0.044708713791632576 1088.6166391342292 2038979.3504529782 0.012061309786043072 0.03144376467943734 5.643884957570316e-06 5.2484218472921755 -0.04949931214522152 GTLDEEDEEADS(ph)DTDDIDHR ddPTM_A459_Selumetinib_30min_R1 1 GTLDEEDEEADSDTDDIDHR 20 0 Q9HCN4-3;Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5 Q9HCN4-3 GPN1 GPN-loop GTPase 1 1 GTLDEEDEEADS(0.993)DT(0.007)DDIDHR 107.75 0.00029135 6116200.0 2154.8 2260.2 2133.3 2052.6 2207.6 2001.5 2044.5 2151.3 1197.0 1809.1 True False 2205.00264748908 1995.5747332615267 1843.6095773781067 1694.1519420739878 2007.922969783437 1981.3667272165985 1890.2817189636078 2094.2405355927644 2031.2215745790193 2041.3156071262642 1.0801870322214664 0.9775924537562661 0.9031477400858727 0.8299314109781345 0.9836416097411625 0.9706322335946567 0.9260114959022531 1.0259268720043773 0.9950551338009632 1.0 10.995283538877553 -7.7644678507356115 24.972744416803494 1.0078682585302037 0.9491683597093482 0.13961133679969084 0.060866014091273464 160.40876709554834 1322679.9785300246 0.03376719275386115 0.017314348156359217 1.7200146630481697e-08 7.7644678507356115 -0.05869989882085547 GTLDEEDEEADS(ph)DTDDIDHR ddPTM_A459_Selumetinib_30min_R2 2 GTLDEEDEEADSDTDDIDHR 20 0 Q9HCN4-3;Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5 Q9HCN4-3 GPN1 GPN-loop GTPase 1 1 GTLDEEDEEADS(1)DTDDIDHR;GTLDEEDEEADS(1)DTDDIDHR 139.45 5.0427e-05 252500000.0 73579.0 72507.0 75070.0 87574.0 92351.0 66820.0 68810.0 69685.0 61547.0 74319.0 True False 69489.77374007425 78068.05375324885 70240.07793003603 75646.27012642362 80749.04175158485 76023.84846843309 72009.80134442826 69887.77181302715 73858.11976686348 72173.21736604818 0.9628193986092647 1.0816762311884094 0.9732152797594203 1.048121074369746 1.1188228084947607 1.0533526319445519 0.9977357802854886 0.9683338828941254 1.0233452582870155 1.0 16.139175948773122 -7.274824190298533 19.295985936762865 0.9947147337349471 1.0425389618062728 0.17271424444439165 0.04495858719390021 65.79390649240855 94845.02266025572 0.018968467329114936 0.01294663815884648 5.310993986773543e-08 7.274824190298533 0.04782422807132569 GTLS(ph)DSEIETNSATSTIFGK ddPTM_A459_Selumetinib_30min_R2 1 GTLSDSEIETNSATSTIFGK 20 0 A0A0A0MRB5;Q8WXG6-6;Q8WXG6-8;Q8WXG6-5;Q8WXG6-4;Q8WXG6-7;Q8WXG6-3;Q8WXG6-2;Q8WXG6;F8W8U2 A0A0A0MRB5 MADD MAP kinase-activating death domain protein 1 GT(0.01)LS(0.951)DS(0.04)EIETNSATSTIFGK 180.31 2.5599e-13 3402800.0 28686.0 23037.0 27661.0 29161.0 31226.0 21720.0 22546.0 27092.0 22821.0 23615.0 True False 27091.74695915646 24803.86382436998 25881.32137501966 25189.221494469148 27303.110716018095 24711.732845470928 23594.43367405145 27170.833234677953 27385.837672016307 22933.173590861414 1.1813344041468463 1.0815713632523154 1.1285538511483229 1.0983748670749496 1.190550911230971 1.0775539960731055 1.0288342161005375 1.1847829576236755 1.19415821641577 1.0 14.48514839460706 GTNS(ph)SDSEELSAGESITK ddPTM_A459_Selumetinib_30min_R1 1 GTNSSDSEELSAGESITK 18 0 Q4LE39-2;Q4LE39;H7C5R6 Q4LE39-2 ARID4B AT-rich interactive domain-containing protein 4B 1 GT(0.012)NS(0.938)S(0.05)DSEELSAGESITK 199.09 1.9646e-10 5698900.0 1529.3 1878.1 2263.5 2427.1 2275.8 1948.6 2045.9 1536.7 1012.4 1769.7 True False 1564.929714500208 1658.2111788949983 1956.1291325155123 2003.252547309643 2069.954291825123 1928.9988531872402 1891.5761158364608 1495.9417240949197 1717.968857229571 1996.858233337765 0.7836959521580134 0.8304100667793951 0.9796034089239407 1.0032021872485108 1.0366055322641397 0.9660169264810066 0.9472761181822487 0.7491476856594075 0.8603359159643357 1.0 10.963516197153263 -10.609298626752315 17.745577177515475 0.9999999992781137 0.911210097250647 0.08311904775266821 0.09209216085929585 0.0 0.0 0.099795862457361 0.02420405187713597 2.4586764036605413e-11 10.609298626752315 -0.08878990202746662 GTNSS(ph)DSEELSAGESITK ddPTM_A459_Selumetinib_30min_R2 2 GTNSSDSEELSAGESITK 18 0 Q4LE39-2;Q4LE39;H7C5R6 Q4LE39-2 ARID4B AT-rich interactive domain-containing protein 4B 1 GTNS(0.013)S(0.982)DS(0.004)EELS(0.002)AGESITK;GTNS(0.08)S(0.92)DSEELSAGESITK 265.42 2.3537999999999997e-43 12980900.0 53419.0 51603.0 59525.0 62766.0 67706.0 49519.0 48667.0 51445.0 44723.0 54312.0 True False 50450.18583320011 55560.78417020288 55695.22630591973 54217.162522610684 59200.16698068026 56339.79276127421 50930.111931831 51594.696432821795 53668.84966502721 52743.87144047703 0.9565127559916528 1.0534073941254922 1.0559563563469812 1.027932934043272 1.1224084498137257 1.0681770454574098 0.9656119382383049 0.9782121604601568 1.0175371697087887 1.0 15.686715849557181 -7.258450875453165 24.982876630034927 0.9885246631827935 1.0505859071851196 0.3196593664324284 0.04058619751765467 310.09633436144185 2592316.695800043 0.01651904012649036 0.012252330053332365 5.5150458143920163e-08 7.258450875453165 0.062061244002326044 GTNTS(ph)SPYDAGADYLR ddPTM_A459_Selumetinib_30min_R2 1 GTNTSSPYDAGADYLR 16 0 Q9UJJ2;Q8ND82 Q9UJJ2 ZNF280C Zinc finger protein 280C 1 GTNT(0.015)S(0.493)S(0.493)PYDAGADYLR 248.01 2.8264999999999997e-29 9772500.0 29493.0 27741.0 37860.0 34377.0 34197.0 26223.0 30905.0 29443.0 24801.0 30635.0 True False 27853.897129833415 29868.645498626025 35424.12881885123 29694.793296367287 29900.867134941116 29834.98022130682 32342.143737095732 29528.67425544895 29761.892997838677 29750.487950710965 0.9362500936448598 1.003971617141568 1.1907074894885776 0.9981279414833145 1.0050546795897697 1.002840029741221 1.0871130514120806 0.9925441997580172 1.0003833566409601 1.0 14.860625710433824 GTNTSS(ph)PYDAGADYLR ddPTM_A459_Selumetinib_30min_R1 2 GTNTSSPYDAGADYLR 16 0 Q9UJJ2;Q8ND82 Q9UJJ2 ZNF280C Zinc finger protein 280C 1 GTNT(0.012)S(0.112)S(0.876)PYDAGADYLR;GTNTS(0.173)S(0.822)PYDAGADY(0.004)LR 172.95 5.4014e-06 22592000.0 6864.700000000001 7670.0 8277.900000000001 7611.5 8126.599999999999 6699.7 7490.5 7437.799999999999 4101.6 6772.0 True False 7024.634153619026 6771.992834313734 7153.8066472499095 6282.294410550593 7391.550464867761 6632.307100840889 6925.485554363851 7240.52538262067 6960.115630988553 7641.252164865992 0.9193040619596172 0.8862412453093671 0.9362086858149601 0.8221550964429883 0.9673218872233605 0.8679607684373811 0.906328623233612 0.9475574456124037 0.9108606130014576 1.0 12.89959335538651 -9.25062603865258 0.5095429570490604 1.0065429989496861 0.8981245692979889 0.3566191628472378 0.03865449982346542 2.8885153414923614 1.1383055200240284 0.0781132185304939 0.018246641311882906 5.615312900584218e-10 9.25062603865258 -0.10841842965169723 GTNTSS(ph)PYDAGADYLR ddPTM_A459_Selumetinib_30min_R2 1 GTNTSSPYDAGADYLR 16 0 Q9UJJ2;Q8ND82 Q9UJJ2 ZNF280C Zinc finger protein 280C 1 GTNT(0.005)S(0.333)S(0.662)PYDAGADYLR 142.32 0.00039466 12703000.0 53299.0 46454.0 56257.0 59476.0 61879.0 53556.0 53166.0 60259.0 52962.0 49904.0 True False 50336.85495280206 50016.87242684736 52637.48586799036 51375.26619817727 54105.206814721234 60932.85286703688 55638.324346430374 60434.343713585535 63555.87988192137 48463.141853836445 1.038662641902514 1.0320600463275147 1.0861344076028672 1.0600894666120433 1.1164197108371783 1.257302984003983 1.1480544227659464 1.2470166275198153 1.3114271475341863 1.0 15.564600316943284 -6.5390132297280035 3.855243895098027 1.2052616336801443 1.056750849587667 0.3972152063634815 0.07954544297033252 0.20660435845611713 6.837904461141758 0.025579352226356676 0.026769322338278004 2.890591826155463e-07 6.5390132297280035 -0.1485107840924773 GTPAGT(ph)TPGASQAPK ddPTM_A459_Selumetinib_30min_R1 1 GTPAGTTPGASQAPK 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 GTPAGT(0.549)T(0.39)PGAS(0.062)QAPK 126.71 0.0024409 0.0 1701.4 1558.0 1548.6 1745.6 1532.9 1479.2 1404.3 1241.3 929.3 1072.0 True False 1741.0393096519015 1375.58863570545 1338.3086258509054 1440.7637289702584 1394.2494656554754 1464.3205910061415 1298.3725203915835 1208.3766916893494 1576.954226613434 1209.6016421642557 1.4393493270534765 1.1372245107440542 1.106404438618621 1.1911059631106324 1.152651763237393 1.210580855682483 1.073388523240177 0.9989873108367192 1.3036971608205656 1.0 10.240316287948641 -4.761531519207826 7.774467589413273 1.1327051617716857 1.4436255872002628 0.5213744603289177 0.08877657047671018 0.07558943457921571 36.69525259241938 0.021057056421617076 0.12381811725242642 1.731683348130839e-05 4.761531519207826 0.3109204254285771 GTPAGTT(ph)PGASQAPK ddPTM_A459_Selumetinib_30min_R1 1 GTPAGTTPGASQAPK 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 GTPAGT(0.352)T(0.644)PGAS(0.004)QAPK 135.14 0.00096105 4740700.0 1868.4 2266.0 2515.2 2407.5 1947.9 1881.9 1975.2 2108.0 1323.9 1804.3 True False 1911.930084726468 2000.695666565179 2173.6496550046477 1987.0753193720773 1771.7127889296771 1862.9697946284864 1826.2090737573578 2052.088992250985 2246.561606169725 2035.8994803703044 0.9391082925070112 0.9827084715406861 1.067660597177071 0.97601838329005 0.8702358864040896 0.9150598114449323 0.8970035561014994 1.0079520192606641 1.1034737362185996 1.0 10.991450616826544 -7.995572600845918 20.870515829955078 1.053062285691816 0.952143610808082 0.3544379306721134 0.056124628080045195 17.596731622218982 82952.56453305102 0.034235504385322614 0.01626524589674661 1.0102466038649299e-08 7.995572600845918 -0.10091867488373396 GTPAGTT(ph)PGASQAPK ddPTM_A459_Selumetinib_30min_R2 1 GTPAGTTPGASQAPK 15 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 GTPAGT(0.343)T(0.657)PGASQAPK 206.67 4.671e-06 6313800.0 21072.0 18642.0 20235.0 22747.0 19960.0 17815.0 20980.0 18197.0 18605.0 19716.0 True False 19900.902597899483 20071.781456522334 18933.102130202187 19648.81935923631 17452.446355335993 20268.85454153154 21955.61157108132 18249.950257324475 22326.519867133946 19146.747851680007 1.0393881379783931 1.0483128316102601 0.9888416704950197 1.026222286491972 0.9115096981759568 1.058605602295696 1.1467018702685245 0.9531618841328793 1.1660737395241214 1.0 14.224811745240363 -6.969924370314493 24.999164813873104 1.0683059379131465 1.0038157838626593 0.1731557824239316 0.06791199307881016 353.1835291758186 293568.94059576484 0.02283970744851344 0.02014247417027398 1.0717059199150826e-07 6.969924370314493 -0.06449015405048719 GTPGS(ph)PSGTQEPR ddPTM_A459_Selumetinib_30min_R1 3 GTPGSPSGTQEPR 13 0 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GT(0.047)PGS(0.915)PS(0.037)GTQEPR;GT(0.024)PGS(0.937)PS(0.039)GT(0.001)QEPR;GT(0.001)PGS(0.962)PS(0.037)GTQEPR 175.6 9.893e-05 24763900.0 3493.5 4262.66 4178.9 5011.8 4558.799999999999 3502.4700000000003 3931.1600000000003 3621.6000000000004 2154.4300000000003 3060.49 True False 3574.891752832327 3763.5857855431295 3611.428333054597 4136.583213137684 4146.457344921509 3467.2383317883177 3634.629436204925 3525.5434033852794 3655.910356658542 3453.3337031970946 1.0352002036532681 1.0898413269643776 1.045780293318059 1.1978521535025812 1.2007114577669458 1.0040264364194953 1.052498758761711 1.020910142602591 1.0586611868044788 1.0 11.753774036370304 -6.794050886557658 24.999945153265724 1.0301061305070984 1.1134240159284485 0.39254657770467494 0.05383859136144928 232.70074443453186 178386.5551755491 0.020513105528152657 0.018092218741475014 1.6067529777257226e-07 6.794050886557658 0.0833178854213501 GTPGS(ph)PSGTQEPR ddPTM_A459_Selumetinib_30min_R2 2 GTPGSPSGTQEPR 13 0 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GT(0.001)PGS(0.731)PS(0.158)GT(0.11)QEPR;GT(0.02)PGS(0.685)PS(0.286)GT(0.009)QEPR 153.14 0.00041975 18132800.0 30361.0 27501.0 31778.0 35332.0 36902.0 25226.0 24661.2 29777.0 28122.0 30773.0 True False 28673.657164712728 29610.238270347665 29733.438077270326 30519.720648900395 32266.040851934307 28700.65252117171 25807.994665240727 29863.64614015226 33747.18579433168 29884.50353214391 0.9594824666861609 0.9908224922826225 0.9949450237742414 1.0212557359727674 1.079691379755692 0.9603857895882779 0.8635912133350828 0.9993020666390119 1.12925368688267 1.0 14.867109955183524 -8.024501781532095 24.436869005499954 1.0645105673030966 0.9828755783838466 0.23652782321678767 0.05889841567584998 881.8366815316953 879493.2745643917 0.041469325070056365 0.015864110933229026 9.451445153278208e-09 8.024501781532095 -0.08163498891924992 GTPGSPS(ph)GTQEPR ddPTM_A459_Selumetinib_30min_R1 1 GTPGSPSGTQEPR 13 0 Q5SXM2 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 GTPGS(0.453)PS(0.544)GT(0.003)QEPR 162.67 0.00036327 5359700.0 2409.8 3004.4 3204.5 3306.8 2929.7 3154.2 3006.1 2702.6 1741.6 2226.6 True False 2465.9436513454543 2652.643451292334 2769.3465010585223 2729.329456323814 2664.709152280544 3122.4716117844587 2779.347456775004 2630.918268717987 2955.367998568768 2512.405798920645 0.9815069095943214 1.0558180738286531 1.1022687904351525 1.086341011271492 1.0606205229367525 1.2428213679199054 1.1062494195679058 1.0471709107852945 1.1763099734280285 1.0 11.294853789022188 -4.199339071772804 0.9618939000565787 1.1111090464144355 0.713506612135888 0.25144378455643923 0.06404821875175429 7.202649476291093 2.4210129694628746 0.020625997336013936 3.894791667598198 6.319182938250302e-05 4.199339071772804 -0.3976024342785476 GTPKPPGPPAQPPGPPNAS(ph)SNPDLR ddPTM_A459_Selumetinib_30min_R1 1 GTPKPPGPPAQPPGPPNASSNPDLR 25 1 Q8N4C8;Q8N4C8-4 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 GTPKPPGPPAQPPGPPNAS(0.5)S(0.5)NPDLR 94.269 5.3272e-06 20895000.0 1144.2 1558.6 1634.0 1699.1 1389.4 1127.1 1269.2 1329.6 624.56 1109.4 True False 1170.857633774366 1376.118387426518 1412.1117749195264 1402.3840810571535 1263.729015318494 1115.7623973249201 1173.4632221612178 1294.3346888505262 1059.832703942415 1251.8022964711065 0.9353375026352583 1.0993096843693806 1.1280629368553967 1.1202919862110372 1.0095276377755573 0.8913247726660275 0.9374189722045322 1.033976924710332 0.8466454382853719 1.0 10.289791012728859 -6.520115768092374 5.78816090437865 0.9439029121672559 1.0759796101437193 0.4313815945987868 0.06968627439324358 0.15163167328604232 19.15049472107127 0.02259738983417275 0.023856620235811088 3.01914681158818e-07 6.520115768092374 0.1320766979764635 GTPLT(ph)PPACACSSLQVEVER ddPTM_A459_Selumetinib_30min_R2 1 GTPLTPPACACSSLQVEVER 20 0 Q8TD19 Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 1 GTPLT(0.991)PPACACS(0.006)S(0.002)LQVEVER 100.27 0.0017996 5013800.0 48182.0 51381.0 60513.0 68460.0 55241.0 43852.0 49117.0 54071.0 44305.0 58242.0 True False 45504.23732782808 55321.75748404539 56619.65946157277 59135.62989991285 48301.13171919412 49892.21495117822 51401.0378234891 54228.337658064076 53167.237985131396 56560.40212911077 0.8045246429464077 0.9781004979024385 1.0010476823047816 1.0455305774687313 0.8539743336501893 0.8821050253017819 0.9087813362103693 0.9587686016495555 0.9400081326113315 1.0 15.787504756903472 -8.88303905659407 1.3883499702146085 0.9997460383564789 0.9318830175945391 0.08904103063697866 0.06767394817992546 4.085256508173552 11.927921147889267 0.0681916720634305 0.020081423839819878 1.3090641920819256e-09 8.88303905659407 -0.06786302076193984 GTPPLTPSDS(ph)PQTR ddPTM_A459_Selumetinib_30min_R1 1 GTPPLTPSDSPQTR 14 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 GTPPLTPS(0.003)DS(0.996)PQT(0.001)R 196.37 0.00011754 15214000.0 810.73 1005.1 1202.3 1424.4 1166.6 971.38 1050.5 851.13 481.69 671.11 True False 829.6184315940327 887.4224247416873 1039.0342637611675 1175.6552792995162 1061.0812359799581 961.6087991424725 971.2599392375979 828.5552675401237 817.3927487543589 757.2535056649757 1.0955623518249815 1.1718960930559243 1.3721088855821781 1.5525253703079587 1.401223273371549 1.2698637800270651 1.2826087062940623 1.0941583780619608 1.0794175829355486 1.0 9.564632541691072 -7.80904979208835 1.7643895213223453 1.0301609886725336 1.3236207657185133 0.4815447154849798 0.11904214517738122 0.3645296785409018 2.1548727268240664 0.10471105608513442 0.04013060996727351 1.5522090381820255e-08 7.80904979208835 0.2934597770459797 GTPPLTPSDS(ph)PQTR ddPTM_A459_Selumetinib_30min_R2 3 GTPPLTPSDSPQTR 14 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 GTPPLT(0.109)PS(0.043)DS(0.424)PQT(0.424)R;GTPPLTPS(0.004)DS(0.993)PQT(0.003)R;GTPPLTPSDS(0.999)PQTR 272.09 1.7604e-44 36585700.0 56726.6 55332.3 65273.0 76020.0 70829.0 55203.5 54529.8 54667.6 46433.3 60808.9 True False 53573.96266657197 59576.1094886134 61073.40624386894 65665.94485818555 61930.82780070602 62807.28103752096 57065.54374874881 54826.67366529161 55721.25745480198 59053.18905650358 0.9072154022928559 1.008855075237503 1.0342101285238359 1.1119796560919804 1.0487296078362347 1.063571367456978 0.9663414399880599 0.9284286681424109 0.9435774484843905 1.0 15.849727351310253 -7.3856515435304 5.493330825047275 0.9513333829328464 1.0328454751173677 0.2985587436332835 0.05178782454325265 0.28352612546914063 11.528714498834953 0.023625271867739613 0.015686313193584867 4.114797397373625e-08 7.3856515435304 0.08151209218452127 GTPSQS(ph)PVVGR ddPTM_A459_Selumetinib_30min_R1 6 GTPSQSPVVGR 11 0 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 1 GTPS(0.015)QS(0.984)PVVGR;GTPS(0.002)QS(0.998)PVVGR;GTPS(0.012)QS(0.988)PVVGR;GTPS(0.005)QS(0.995)PVVGR;GT(0.002)PS(0.051)QS(0.948)PVVGR;GT(0.009)PS(0.283)QS(0.708)PVVGR 150.9 0.00060533 1278239000.0 16009.399999999998 21709.699999999997 22283.0 29195.1 25953.6 17950.3 21048.4 18012.6 10973.100000000002 14415.5 True False 16382.387871130335 19167.91823143429 19257.090991757545 24096.723844901222 23606.101462480245 17769.73627956838 19460.70224183595 17534.84733482928 18620.54925648541 16265.869843860859 1.0071633443761665 1.1784133535698207 1.183895554102546 1.4814285418615913 1.451265852307909 1.0924553343991694 1.196413252327904 1.0780147328823835 1.1447619730901306 1.0 13.989560354456584 GTPSQS(ph)PVVGR ddPTM_A459_Selumetinib_30min_R2 5 GTPSQSPVVGR 11 0 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 1 GTPS(0.005)QS(0.995)PVVGR;GT(0.001)PS(0.019)QS(0.981)PVVGR;GT(0.002)PS(0.059)QS(0.939)PVVGR;GT(0.038)PS(0.12)QS(0.843)PVVGR;GT(0.001)PS(0.123)QS(0.876)PVVGR 145.61 0.0006987 1166761200.0 137876.0 131634.0 177748.0 154176.0 177639.0 111349.5 113272.7 125056.7 122978.0 138819.0 True False 130213.40388135858 141729.90452997855 166311.8871973892 133176.9628315651 155322.40070719089 126686.88289487884 118540.1049955969 125420.59429274886 147577.03629241587 134810.93477492244 0.9658964541619728 1.0513235055198444 1.2336676359010499 0.9878795296087414 1.152149868009698 0.9397374412275432 0.8793063054826303 0.9303443708193887 1.0946963355666026 1.0 17.040577995479907 -6.777591252957123 24.995614705450436 0.9588689750071661 1.0803123189853734 0.2716076868166166 0.08877183623334883 308.50080082672184 477413.3493118504 0.031425529571227635 0.027800315438979248 1.6688171223563947e-07 6.777591252957123 0.12144334397820733 GTQEVAPPTPLT(ph)PTSHTANT(ph)SPRPVSGMER ddPTM_A459_Selumetinib_30min_R2 1 GTQEVAPPTPLTPTSHTANTSPRPVSGMER 30 1 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 2 GTQEVAPPT(0.065)PLT(0.919)PT(0.015)S(0.015)HT(0.111)ANT(0.368)S(0.368)PRPVS(0.138)GMER 65.248 0.00070671 3972800.0 13146.0 9174.3 15790.0 18613.0 19536.0 11651.0 12792.0 14828.0 12444.0 14680.0 True False 12415.39794760756 9877.939309976015 14774.088590852112 16077.877290784072 17081.71302594408 13255.819492752384 13386.85334686713 14871.147025092449 14933.147714410898 14256.1502567794 0.8708801271018812 0.6928896744251583 1.0363308694664193 1.1277853418483974 1.1981995642772498 0.9298316343466346 0.9390230255535584 1.0431390492689703 1.0474880977990224 1.0 13.799296827299708 -5.275343176587914 23.998542173921646 1.0429775722286412 0.781884917640308 0.5949878337452135 0.0852330364537326 282.0521831059136 486834.6643682346 0.023820125510409424 0.050035888028169655 5.3046510860234146e-06 5.275343176587914 -0.2610926545883332 GTQEVAPPTPLTPT(ph)SHTANTSPRPVSGMER ddPTM_A459_Selumetinib_30min_R1 1 GTQEVAPPTPLTPTSHTANTSPRPVSGMER 30 1 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GTQEVAPPT(0.008)PLT(0.021)PT(0.194)S(0.194)HT(0.194)ANT(0.194)S(0.194)PRPVS(0.002)GMER 60.382 0.0035458 16690000.0 2037.1 2687.2 2548.3 2865.2 2926.0 2261.9 2543.6 2205.1 1241.1 2442.8 True False 2084.56046649341 2372.581374754612 2202.254856809933 2364.8466064651598 2661.343816627258 2239.147339640882 2351.7342041358906 2146.6135848257336 2106.0560536424546 2756.3571748869813 0.7562737099116638 0.8607670284428559 0.798972962167079 0.857960872419274 0.9655293736510694 0.8123574695041812 0.8532037232193316 0.7787864375427873 0.7640722591508152 1.0 11.428547132446758 -4.031971963139639 1.8589789736990758 0.8491055623983262 6.61318626774828e-11 0.1324108792577816 0.07276347292294155 30.379863634845993 12.877897474833706 0.019398786353399713 87.8063975820871 9.290263602372942e-05 4.031971963139639 -0.8491055623321944 GTQEVAPPTPLTPT(ph)SHTANTSPRPVSGMER ddPTM_A459_Selumetinib_30min_R2 2 GTQEVAPPTPLTPTSHTANTSPRPVSGMER 30 1 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GTQEVAPPT(0.001)PLT(0.001)PT(0.196)S(0.196)HT(0.196)ANT(0.196)S(0.196)PRPVS(0.016)GMER;GTQEVAPPT(0.001)PLT(0.027)PT(0.189)S(0.189)HT(0.189)ANT(0.189)S(0.189)PRPVS(0.027)GMER 60.993 0.0030837 29153100.0 79847.0 63948.0 84805.0 73222.0 85936.0 62590.0 66512.0 70782.0 51919.0 72102.0 True False 75409.42339286637 68852.60597477155 79348.73862870249 63249.0372850047 75139.95140241257 71211.20436455008 69604.93979102776 70987.96390140902 62304.25073806648 70020.22791650616 1.0769662658451558 0.9833245052682931 1.1332259404142453 0.9032966496542171 1.073117778079947 1.0170090341531604 0.9940690263680146 1.0138208059827627 0.889803598073968 1.0 16.095484137309555 -8.11162900554339 7.3614509018167595 0.9452688635178275 1.0236498037752715 0.2013079198436143 0.06356635958651263 0.39874263288744544 23.31140783499055 0.04019462116015695 0.015043724779760055 7.733409266377585e-09 8.11162900554339 0.07838094025744402 GTQEVAPPTPLTPTSHTANT(ph)SPRPVSGMER ddPTM_A459_Selumetinib_30min_R2 1 GTQEVAPPTPLTPTSHTANTSPRPVSGMER 30 1 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GTQEVAPPTPLT(0.002)PT(0.119)S(0.119)HT(0.119)ANT(0.276)S(0.276)PRPVS(0.088)GMER 53.777 0.0036699 8184500.0 38061.0 30101.0 47446.0 41413.0 42341.0 30480.0 31184.0 35396.0 31217.0 38412.0 True False 35945.72199025494 32409.64991003 44393.37601529887 35772.477958590294 37021.74504665734 34678.3433301084 32634.11778992372 35498.99649987674 37461.27227585706 37302.945753638305 0.963616177329615 0.8688228035414323 1.1900769528628716 0.9589719319981924 0.9924617023857014 0.9296408803512812 0.8748402339442799 0.9516405683970516 1.0042443436843942 1.0 15.18700194183587 -6.713520231594209 7.618256859528972 0.9442618113898811 0.9968832979756224 0.05859579869826459 0.08250850340799992 0.6423965897220123 86.21854958730448 0.02793161090066415 0.027735631157413138 1.9341037563604754e-07 6.713520231594209 0.052621486585741284 GTQEVAPPTPLTPTSHTANTS(ph)PRPVSGMER ddPTM_A459_Selumetinib_30min_R1 1 GTQEVAPPTPLTPTSHTANTSPRPVSGMER 30 1 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GTQEVAPPT(0.032)PLT(0.024)PT(0.108)S(0.108)HT(0.092)ANT(0.092)S(0.52)PRPVS(0.024)GMER 61.499 0.0010732 21615000.0 1646.5 2037.9 1835.9 1998.1 1955.7 1724.8 1739.3 1925.3 761.71 1446.5 True False 1684.8602464687067 1799.3017206059933 1586.5948638768414 1649.1693439822825 1778.807280306879 1707.4500779931 1608.1032006815356 1874.2347897442241 1292.5662369027427 1632.172365103169 1.0322808316646184 1.1023968785871827 0.9720755588068992 1.0104137156359947 1.0898403369269403 1.0461211784364286 0.9852532949728553 1.1483069005556619 0.7919299851771722 1.0 10.67257770542047 -8.261145059784578 24.999992331018078 0.8959650009488966 1.0455389005083333 0.4366535233652179 0.0691696488168542 22.9369937629248 1948767.367925531 0.05022337196739522 0.016294779210148772 5.480938641431209e-09 8.261145059784578 0.14957389955943667 GTQEVAPPTPLTPTSHTANTSPRPVS(ph)GMER ddPTM_A459_Selumetinib_30min_R2 1 GTQEVAPPTPLTPTSHTANTSPRPVSGMER 30 1 P48730-2;H7BYT1;P48730 P48730-2 CSNK1D Casein kinase I isoform delta 1 GTQEVAPPT(0.001)PLT(0.005)PT(0.035)S(0.063)HT(0.197)ANT(0.197)S(0.197)PRPVS(0.306)GMER 54.167 0.0025495 42542000.0 35272.0 23808.0 47693.0 43951.0 50662.0 30840.0 33562.0 32368.0 29156.0 37094.0 True False 33311.723445003365 25633.997045214233 44624.48430421216 37964.79798029607 44297.386635973526 35087.930062353764 35122.69950184134 32462.185521189156 34988.01468670559 36022.99983821358 0.9247348525834301 0.7116008428043634 1.2387775727904269 1.0539043986009906 1.2296973276773686 0.9740424234500347 0.9750076245616505 0.9011516438659538 0.9712687683936286 1.0 15.13663070714308 -10.603426144917986 14.596685728686369 0.9999999984059723 1.000727594056892 0.0 0.14609883172165464 0.0 0.0 0.14821255960526694 0.035946825782098187 2.4921481439793315e-11 10.603426144917986 0.0007275956509197323 GTQGATAGAS(ph)SELDASK ddPTM_A459_Selumetinib_30min_R2 1 GTQGATAGASSELDASK 17 0 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 1 GTQGAT(0.001)AGAS(0.5)S(0.5)ELDASK 188.84 6.9332e-08 3282000.0 17241.0 14400.0 19903.0 21712.0 21378.0 16891.0 14244.0 15809.0 12125.0 18519.0 True False 16282.81424119139 15504.433696702165 18622.46264874793 18754.788144710896 18692.304518255136 19217.581928768406 14906.374223950534 15855.001572679164 14550.338800806176 17984.308351859527 0.9053900724243195 0.8621089781914827 1.035483949919176 1.0428417806110237 1.039367439244468 1.0685749795199304 0.8288544620293533 0.8816019644725342 0.8090574580980042 1.0 14.13445105631328 -10.711893036164673 5.910698139473778 1.0000008618192178 0.9464316708094578 0.03203092020312737 0.09299191204541969 1.1648663167466471e-06 1.5986728342799927e-07 0.09931397701381041 0.02408679003181197 1.941363963716283e-11 10.711893036164673 -0.05356919100975999 GTQSIPNDS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 4 GTQSIPNDSPAR 12 0 J3QRX6;H9KV77;Q9NQ92 J3QRX6 COPRS Coordinator of PRMT5 and differentiation stimulator 1 GTQSIPNDS(1)PAR;GTQSIPNDS(1)PAR;GTQSIPNDS(1)PAR;GTQSIPNDS(1)PAR 209.53 6.9803e-06 230811600.0 17336.2 19398.5 12965.2 12020.999999999998 17007.399999999998 14061.599999999999 20345.3 19591.500000000004 11356.800000000001 18134.2 True False 17740.09972962697 17127.314601882008 11204.597052745805 9921.758012117027 15469.083672900353 13920.153070911267 18810.63764090499 19071.869777839267 19271.660132146204 20461.901212066274 0.8669819849958873 0.8370343705785327 0.5475833812616843 0.48488935164373775 0.755994446096647 0.6802961722199414 0.9193005794501862 0.9320673372517646 0.9418313543993561 1.0 14.320652578483584 -7.298320646116688 4.19705892113841 0.9479092045295685 0.687275209030418 0.5544662074600287 0.11105269217304642 0.19054339262337183 7.6471250779978615 0.05314456855406517 0.036075898339539045 5.031290039494202e-08 7.298320646116688 -0.26063399549915045 GTQSIPNDS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 3 GTQSIPNDSPAR 12 0 J3QRX6;H9KV77;Q9NQ92 J3QRX6 COPRS Coordinator of PRMT5 and differentiation stimulator 1 GTQSIPNDS(1)PAR;GTQSIPNDS(1)PAR;GTQSIPNDS(1)PAR 160.63 0.00047455 381557100.0 195606.0 144830.0 192236.0 198643.0 217030.0 180463.0 230581.0 220894.0 206880.0 161050.0 True False 184735.001592859 155937.99529815078 179867.74505073146 171587.48072171156 189764.75112718256 205320.14016999185 241303.47338758362 221536.76496902993 248261.7807101677 156400.06804184738 1.1811695730428335 0.9970455719778014 1.1500490204557003 1.097106176934658 1.2133290829285823 1.312788048884065 1.5428604118191238 1.4164748631039865 1.5873508484903038 1.0 17.25488161472667 -6.717831472739317 2.070286621094744 1.42118422537328 1.1027293649898966 0.38694309955116035 0.15603973078557976 0.27724484581062736 2.443775961088089 0.0573485572713114 0.05431162713346681 1.9149988930344215e-07 6.717831472739317 -0.31845486038338344 GTQSTEGS(ph)PVSK ddPTM_A459_Selumetinib_30min_R1 3 GTQSTEGSPVSK 12 0 A0A087WXK8;Q9H4H8-2;Q9H4H8 A0A087WXK8 FAM83D Protein FAM83D 1 GTQS(0.001)T(0.001)EGS(0.85)PVS(0.149)K;GTQST(0.001)EGS(0.996)PVS(0.003)K;GTQSTEGS(0.995)PVS(0.005)K 174.21 0.00015219 53575000.0 11171.8 12190.7 13465.7 14241.800000000001 12683.999999999998 10224.1 11373.0 10632.3 5841.6 10261.8 True False 11432.081203461332 10763.407176697328 11637.131901795516 11754.73698169605 11536.734439542077 10121.25483674005 10515.125453545166 10350.29686542227 9912.768546416697 11579.00198839661 0.9873114466097761 0.9295625985282155 1.0050202870210367 1.0151770414648469 0.9963496380001584 0.8741042489570883 0.9081201872218727 0.8938850581245573 0.8560986997282101 1.0 13.49922329017888 -6.75509274699105 24.999815024946237 0.899914361583642 0.9861123984483693 0.47989649042018434 0.04148877406312094 123.9033548541705 488063.48820795806 0.013537695283909348 0.013222425286301999 1.757548235674463e-07 6.75509274699105 0.08619803686472727 GTQSTEGS(ph)PVSK ddPTM_A459_Selumetinib_30min_R2 2 GTQSTEGSPVSK 12 0 A0A087WXK8;Q9H4H8-2;Q9H4H8 A0A087WXK8 FAM83D Protein FAM83D 1 GTQS(0.001)T(0.012)EGS(0.986)PVSK;GTQS(0.001)T(0.053)EGS(0.842)PVS(0.104)K 170.74 0.00029416 45947000.0 77328.0 70937.0 77535.0 89311.0 89465.0 64696.0 79877.0 83626.0 64114.0 94402.0 True False 73030.41932851038 76377.6398015944 72546.48251372493 77146.68772993154 78225.60687275227 73607.28674818545 83591.43877327272 83869.33781497052 76938.59149483603 91676.36897414755 0.7966111675856701 0.833122435544242 0.7913324155997365 0.841511161417035 0.8532799427823285 0.8029036006971706 0.9118100957602852 0.9148414008262196 0.8392412609244206 1.0 16.484262283954813 -14.522878745269688 0.09006403072021994 1.530083545331549 0.7112881854704705 0.7283443270679417 0.03246658043232322 109.22658696904797 0.6808841807324391 10.989627119811551 0.7643175598132196 3.0000000000735635e-15 14.522878745269688 -0.8187953598610787 GTQSTEGSPVS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 GTQSTEGSPVSK 12 0 A0A087WXK8;Q9H4H8-2;Q9H4H8 A0A087WXK8 FAM83D Protein FAM83D 1 GTQSTEGS(0.038)PVS(0.961)K 107.11 0.0086209 9250400.0 3819.4 4044.3 5462.2 5784.0 4509.4 4204.6 4440.8 4103.8 2374.2 3616.3 True False 3908.384588741316 3570.7914758559373 4720.463241716912 4773.932979126931 4101.525566199231 4162.305541471352 4105.826880691407 3994.953892978933 4028.843995292818 4080.4873307449625 0.9578229931736545 0.8750894651605323 1.1568381075833682 1.1699418702166067 1.0051558144282802 1.0200510880428226 1.0062099322685112 0.9790384258464505 0.9873438314431143 1.0 11.994525747560749 -7.165046103292228 1.898931573015366 0.9889808693078173 1.0376282465119522 0.052450057466170596 0.08111960704937148 1.2618416828727452 8.93317728884224 0.0448942361170142 0.03049576235002148 6.838390492947773e-08 7.165046103292228 0.04864737720413492 GTS(ph)PRPPEGGLGYSQLGDDDLK ddPTM_A459_Selumetinib_30min_R1 1 GTSPRPPEGGLGYSQLGDDDLK 22 1 Q9UQ88-8;P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 Q9UQ88-8;P21127;Q5QPR4 CDK11A;CDK11B Cyclin-dependent kinase 11A;Cyclin-dependent kinase 11B 1 GT(0.215)S(0.785)PRPPEGGLGYSQLGDDDLK 123.71 1.7754e-05 55287000.0 3209.2 4096.3 2317.6 2465.4 2341.5 2640.8 3461.6 3109.0 1660.5 3470.2 True False 3283.968115983828 3616.703291681797 2002.8826496655427 2034.8641712896854 2129.7117384254 2614.235949654556 3200.4887250498523 3026.5392205447397 2817.7472218784114 3915.633972610447 0.8386810766672594 0.9236571438955615 0.5115091613964814 0.5196768098150647 0.5438995966738891 0.6676405322716402 0.8173615683787148 0.7729372157140183 0.7196145609084844 1.0 11.935030195012184 -8.965220036180106 0.6631661869071904 1.0020649251356384 0.6734766612757879 0.3203931439500013 0.13350721936390036 2.077101889232068 1.6279009849140214 0.1735899228795803 0.05910491229294098 1.0833778793482688e-09 8.965220036180106 -0.3285882638598505 GTS(ph)PRPPEGGLGYSQLGDDDLK ddPTM_A459_Selumetinib_30min_R2 2 GTSPRPPEGGLGYSQLGDDDLK 22 1 Q9UQ88-8;P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 Q9UQ88-8;P21127;Q5QPR4 CDK11A;CDK11B Cyclin-dependent kinase 11A;Cyclin-dependent kinase 11B 1 GT(0.217)S(0.783)PRPPEGGLGYSQLGDDDLK;GT(0.265)S(0.725)PRPPEGGLGY(0.004)S(0.006)QLGDDDLK 80.277 0.00065788 61257000.0 101203.0 81431.0 83963.0 104169.0 102961.0 96799.0 119292.0 119762.0 95905.0 79799.0 True False 95578.54240770792 87676.49585806612 78560.91199200238 89981.0024984518 90026.11869698139 110132.18359616664 124839.31437261349 120110.48759233362 115088.67980959304 77494.99552729815 1.233351157160074 1.1313826817008006 1.0137546490254168 1.1611201715181125 1.1617023536090025 1.4211522027557484 1.610933887061623 1.5499128269518239 1.4851111226795575 1.0 16.2418155265677 -6.768422330497213 4.076214167210658 1.464907692958465 1.1300667980108596 0.3935975406565493 0.1644445302166939 0.17977892026366807 6.747933880907842 0.05580101288633483 0.051865571490727826 1.7044241123579226e-07 6.768422330497213 -0.3348408949476054 GTS(ph)SPDYR ddPTM_A459_Selumetinib_30min_R2 1 GTSSPDYR 8 0 Q66K14;Q66K14-2;G3V133 Q66K14 TBC1D9B TBC1 domain family member 9B 1 GT(0.051)S(0.606)S(0.343)PDYR 99.136 0.018896 67388000.0 83182.0 80336.0 89752.0 99026.0 99604.0 69513.0 95400.0 101950.0 84957.0 101980.0 True False 78559.07744392913 86497.51287904597 83977.45403458887 85538.48797062188 87090.85504894219 79087.78477381315 99836.28903151373 102246.65762126894 101950.77389691485 99035.57242413925 0.7932410094777307 0.8733984240390253 0.8479524273857778 0.8637147832526937 0.8793896265471011 0.7985795693198421 1.0080851414070215 1.0324235536639057 1.0294359026905069 1.0 16.595659197085055 -7.297039723188255 9.196391847912261 1.0204743000083594 0.8469893231155652 0.9008424295712767 0.028378908738362588 0.12823635505977152 31.920758502606315 0.0114956882905223 0.007792665153733506 5.046151403135682e-08 7.297039723188255 -0.17348497689279418 GTSPRPPEGGLGYS(ph)QLGDDDLK ddPTM_A459_Selumetinib_30min_R1 1 GTSPRPPEGGLGYSQLGDDDLK 22 1 Q9UQ88-8;P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5;Q9UQ88-10 Q9UQ88-8;P21127;Q5QPR4 CDK11A;CDK11B Cyclin-dependent kinase 11A;Cyclin-dependent kinase 11B 1 GT(0.167)S(0.151)PRPPEGGLGY(0.247)S(0.435)QLGDDDLK 55.707 0.013682 48204000.0 3078.2 4186.3 2402.8 2582.9 2525.0 2958.5 3307.1 3218.0 1933.0 3813.6 True False 3149.9160708654545 3696.166049841931 2076.512957635641 2131.8450020378555 2296.614195824957 2928.740176103074 3057.642784438516 3132.6481864628417 3280.159819265865 4303.112707609706 0.7320087306323823 0.858951717277951 0.48256067147939125 0.495419280621644 0.5337099796999462 0.6806096830612487 0.7105653493647337 0.7279958484292096 0.7622760643627037 1.0 12.071164912673181 -8.651468222061755 0.7753171563339192 0.9981311887493624 0.627123867022829 0.5042259836166462 0.10867079829682097 0.7706771035187493 0.9996549253900443 0.11939689311157813 0.04366240722979281 2.2311654590248487e-09 8.651468222061755 -0.3710073217265334 GTSS(ph)PDYR ddPTM_A459_Selumetinib_30min_R2 1 GTSSPDYR 8 0 Q66K14;Q66K14-2;G3V133 Q66K14 TBC1D9B TBC1 domain family member 9B 1 GT(0.013)S(0.078)S(0.909)PDYR 101.25 0.017183 38149000.0 82264.0 76552.0 77760.0 98972.0 101890.0 81037.0 92250.0 100470.0 79369.0 97201.0 True False 77692.09620888399 82423.29224652391 72757.00625868648 85491.84286377719 89089.66729184274 92199.11116935684 96539.80778990715 100762.351066296 95245.01775514925 94394.55457147227 0.8230569714703007 0.8731784648034528 0.7707754603958368 0.9056861728082602 0.9438009183505087 0.9767418426615583 1.0227264509925789 1.0674593627114608 1.0090096636139434 1.0 16.52641601541486 -6.423276509534264 1.2127076311144027 1.029075336641757 0.8260339442223656 0.8621219052931375 0.03337038733991214 0.15436703692518525 0.47134692759576186 0.014414999457048555 0.01792349716990333 3.773318722331868e-07 6.423276509534264 -0.20304139241939145 GTT(ph)PPPPSWEPNSQTK ddPTM_A459_Selumetinib_30min_R1 2 GTTPPPPSWEPNSQTK 16 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 GT(0.014)T(0.986)PPPPSWEPNSQTK;GT(0.071)T(0.929)PPPPSWEPNSQTK 261.61 8.0728e-39 20214000.0 4496.7 6407.9 4456.3 5183.8 5136.3 4574.0 5687.8 5050.200000000001 2726.73 4825.4 True False 4601.464360944934 5657.660089048112 3851.158936703724 4278.546641977557 4671.72257188742 4527.989712859711 5258.7646667259505 4916.252290638485 4627.061657520338 5444.787093376309 0.8451137357680535 1.0390966610853833 0.7073112080706948 0.7858060505584311 0.8580174930201886 0.831619241525183 0.9658347657199199 0.9029282883474365 0.8498149841615018 1.0 12.410659921237787 -7.246053600384582 24.130028900902037 0.9215552021044725 0.8450511131233627 0.18785252953103593 0.0860769250833909 1030.544413984517 1616238.6726402096 0.03403626018196756 0.026252920721654152 5.6747456368981784e-08 7.246053600384582 -0.07650408898110983 GTT(ph)PPPPSWEPNSQTK ddPTM_A459_Selumetinib_30min_R2 4 GTTPPPPSWEPNSQTK 16 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 GT(0.002)T(0.998)PPPPSWEPNSQTK;GT(0.02)T(0.98)PPPPSWEPNSQTK;GT(0.003)T(0.997)PPPPSWEPNSQTK;GT(0.001)T(0.999)PPPPSWEPNSQTK 193.98 2.7758e-06 41683000.0 186323.0 157430.0 198828.0 192875.0 205851.0 149335.0 181627.0 184870.0 169040.0 178469.0 True False 175967.91357006598 169504.3747827652 186035.62294755832 166605.09227206706 179990.15704871088 169904.54072184153 190073.01538707298 185407.94109312416 202852.723372229 173316.13625184994 1.0153002332937002 0.9780068864243213 1.0733889352185038 0.9612785968755333 1.0385077866446477 0.9803157651457742 1.0966838950925677 1.069767334437362 1.1704202953004832 1.0 17.403046454421244 -7.271131234945648 24.554450469835096 1.0900318333011303 1.008708036984924 0.3650268393991035 0.04912867967109754 545.025452064195 1380822.948821753 0.01898303105048612 0.012978927081330494 5.3563477513788095e-08 7.271131234945648 -0.08132379631620634 GTTATSAQANSTPTSVASVVTSAES(ph)PASR ddPTM_A459_Selumetinib_30min_R1 1 GTTATSAQANSTPTSVASVVTSAESPASR 29 0 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 GTTATSAQANSTPTS(0.002)VAS(0.013)VVT(0.246)S(0.042)AES(0.646)PAS(0.05)R 106.37 1.0334e-10 8121200.0 1113.0 1466.0 1430.0 1712.5 1579.1 1276.5 1108.4 1213.2 844.92 1246.3 True False 1138.9307344789986 1294.3600384750891 1235.8138544277383 1413.444022606305 1436.2706838127492 1263.659568969267 1024.7924956220404 1181.0219949710138 1433.7675294847984 1406.2747449900312 0.809892048859252 0.9204176090670423 0.8787854996546203 1.0050980632638216 1.0213300700518024 0.8985865482340186 0.7287285071945916 0.8398230851961903 1.019550080517845 1.0 10.45766276706132 -4.0217221270261145 0.008336582331294782 1.767466885318606 7.372857952233329e-07 0.06895474171988525 0.09179749109792064 57258.47051278809 60.42844632859353 5938.284066500792 6902.390289973691 9.512132100977565e-05 4.0217221270261145 -1.7674661480328107 GTTATSAQANSTPTSVASVVTSAES(ph)PASR ddPTM_A459_Selumetinib_30min_R2 1 GTTATSAQANSTPTSVASVVTSAESPASR 29 0 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 GTTATSAQANSTPTSVASVVT(0.007)S(0.017)AES(0.784)PAS(0.192)R 125.26 8.41e-14 4148200.0 11273.0 11337.0 9294.1 13628.0 13981.0 8480.9 9531.4 11196.0 9436.1 11032.0 True False 10646.491789394497 12206.51144579948 8696.127724650962 11771.842890388727 12224.581788274172 9649.066993054992 9974.628986110802 11228.578506402426 11323.583666662858 10713.47749542169 0.9937475291234038 1.139360347843716 0.8116998172038141 1.0987882221640284 1.1410470403749147 0.9006475252483086 0.931035603553876 1.0480797211923822 1.0569475384161577 1.0 13.387139221083114 -7.6515641621115 0.003734641518796976 0.46659038572639605 1.5535314457536504 0.000427350727640774 0.10160493247941638 151059.04620634016 499.69370112359354 72529.00735125119 72887.29006751555 2.230672626414758e-08 7.6515641621115 1.0869410600272544 GTVPDDAVEALADS(ph)LGKK ddPTM_A459_Selumetinib_30min_R1 1 GTVPDDAVEALADSLGKK 18 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 GTVPDDAVEALADS(1)LGKK 114.87 0.00055204 4085800.0 617.26 751.22 842.46 1059.4 782.75 946.25 689.71 756.06 418.22 693.41 True False 631.6409570211196 663.2668131672966 728.0585593015331 874.3956774009467 711.950400705737 936.7315841262582 637.6846194112933 736.0068327710055 709.688794419747 782.4159278853699 0.8072956269285714 0.8477163993323898 0.930526249982221 1.1175586363178596 0.9099385318367949 1.1972296968160607 0.815019987048013 0.9406848794096078 0.907047989600388 1.0 9.611791929757276 -5.309423953726842 3.3460815706470513 0.9823559014215101 0.8213942151175537 0.26230139966255883 0.1032772907743708 0.3208487629276965 7.231643689080925 0.027496036806391688 0.0709678196187039 4.9042889085120515e-06 5.309423953726842 -0.16096168630395635 GTVPDDAVEALADS(ph)LGKK ddPTM_A459_Selumetinib_30min_R2 2 GTVPDDAVEALADSLGKK 18 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 GTVPDDAVEALADS(1)LGKK;GTVPDDAVEALADS(1)LGKK 98.281 0.0016995 7323600.0 26079.2 21074.0 22156.0 21301.5 19172.4 15940.1 16698.7 18362.5 12784.1 18475.8 True False 24629.822467309223 22690.30803640983 20730.507081628843 18400.198952862876 16763.791708569308 18135.704085179157 17475.222637846313 18415.93183492447 15341.277217598865 17942.3556481066 1.372719555356062 1.2646225769582415 1.155394948590068 1.02551745789325 0.9343138681089702 1.010776089877193 0.9739647892717151 1.0263943149999841 0.8550313859829092 1.0 14.131081693370655 -5.375177125849106 1.2107783712233935 0.9667682633681088 1.3928803989702427 0.9006817653027096 0.0469857585822564 0.185415494211476 0.43421485865714077 0.014949641515957155 0.07645389148489572 4.215245506990982e-06 5.375177125849106 0.4261121356021339 GTVT(ph)PPPR ddPTM_A459_Selumetinib_30min_R2 1 GTVTPPPR 8 0 P00519;P00519-2 P00519 ABL1 Tyrosine-protein kinase ABL1 1 GT(0.003)VT(0.997)PPPR 106.68 0.031859 7172500.0 25232.0 14763.0 25388.0 25530.0 26327.0 19382.0 24208.0 20192.0 21451.0 19878.0 True False 23829.706451698934 15895.2746294732 23754.563720364386 22052.769958293524 23019.566893633797 22051.694567721806 25333.719967241985 20250.755377034457 25741.799391018016 19304.070490753467 1.2344394651435415 0.8234156955180484 1.2305468803454005 1.1423896306665824 1.1924721734030153 1.1423339226969997 1.3123511944994546 1.0490406873894522 1.3334907476300495 1.0 14.236617468371303 GTVTDFPGFDER ddPTM_A459_Selumetinib_30min_R2 2 GTVTDFPGFDER 12 0 P08758;E9PHT9;D6RBE9;D6RCN3 P08758 ANXA5 Annexin A5;Annexin 0 ; 220.82 4.0835e-07 12101500.0 50457.0 49101.0 48215.0 54057.0 56537.0 39892.0 37689.0 38291.0 38393.0 54207.0 False True 47652.80193537461 52866.888815400904 45112.899392522806 46694.3433464737 49434.31661280712 45386.760896479136 39441.61317933669 38402.4204705837 46072.67279004962 52641.90306329979 0.9052256693317873 1.0042738909311577 0.8569769853927268 0.8870185276228638 0.9390678097895573 0.8621793334846456 0.7492436801137247 0.729502890965137 0.8752091035662041 1.0 15.683924024594438 -6.978376547759993 5.575056843198559 0.8143504599413376 0.9171598681840157 0.16402948377268567 0.0789854352966936 0.23253271951392449 22.134390541765434 0.028041602761587056 0.02399134820860589 1.0510501831816279e-07 6.978376547759993 0.10280940824267815 GTYFPAILNPPPS(ph)PATER ddPTM_A459_Selumetinib_30min_R2 1 GTYFPAILNPPPSPATER 18 0 H0YGW5;F5H7J9;O75581 H0YGW5 LRP6 Low-density lipoprotein receptor-related protein 6 1 GTYFPAILNPPPS(0.5)PAT(0.5)ER 106.44 0.0016609 4917400.0 14795.0 8158.4 12077.0 12270.0 7959.2 7085.7 16653.0 11247.0 11168.0 9698.3 True False 13972.75312907758 8784.123046609371 11299.978968443387 10598.80483306939 6959.294139849208 8061.6908574195895 17427.39749729349 11279.726907958922 13401.912059992044 9418.284879790435 1.4835772444152788 0.9326669514380653 1.1997915876053669 1.1253434110718066 0.7389131066509063 0.8559616703374733 1.8503790997752514 1.19764129583325 1.4229673694357658 1.0 13.201248645911235 -7.221612441367327 24.99997691721393 1.3842179275935325 1.0457035145749323 0.23205580625812539 0.27676000970188996 723.8356439989875 454363.1520731095 0.10385307713744386 0.08044302823169297 6.003265607469755e-08 7.221612441367327 -0.3385144130186002 GTYVPSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 4 GTYVPSSPTR 10 0 Q9Y4P8-4;Q9Y4P8 Q9Y4P8-4 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 1 GTYVPS(0.053)S(0.893)PT(0.054)R;GTYVPS(0.003)S(0.997)PT(0.001)R;GTYVPS(0.003)S(0.996)PT(0.001)R;GTYVPS(0.003)S(0.996)PT(0.001)R 147.28 0.00083069 204086000.0 21482.1 27191.6 29495.7 31058.800000000003 26916.6 24459.9 28191.8 26065.9 13631.599999999999 19872.0 True False 21982.59113310988 24007.994830968117 25490.345948282684 25634.963625883058 24481.998282511704 24213.855613812255 26065.26982865159 25374.547658024185 23131.82958732777 22422.764769671747 0.9803693415560765 1.0706973505533313 1.1368065539696532 1.1432561456719208 1.0918367352997078 1.0798782336852177 1.1624467409079977 1.1316422358559868 1.0316225418649123 1.0 14.452676555711351 -4.819125481479992 3.256468417031075 1.1050679536971761 0.9682226484111983 0.3297997166599863 0.048780231008318214 0.31000218157339027 5.278133843779452 0.011953760335051775 0.10276972706943341 1.5166121067050909e-05 4.819125481479992 -0.13684530528597783 GTYVPSS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 GTYVPSSPTR 10 0 Q9Y4P8-4;Q9Y4P8 Q9Y4P8-4 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 1 GTYVPS(0.023)S(0.976)PTR 113.38 0.007664 92961000.0 248470.0 233290.0 310080.0 321940.0 289800.0 213720.0 225430.0 256120.0 215410.0 280260.0 True False 234661.03210421832 251182.5928544198 290129.7903895776 278091.21662252356 253392.73315512852 243157.9900430038 235912.94168107075 256865.26679705168 258498.01905828092 272168.16559707077 0.8621913278852033 0.9228948297586027 1.065994583727687 1.0217624681140025 0.9310153250261525 0.8934108421885943 0.8667910927919698 0.9437741046369319 0.9497731613511783 1.0 18.054138804977846 -6.494732216086568 23.578695723156045 0.9220132703687568 0.9725123185854739 0.07280153589485994 0.060820054718383865 799.1419583488785 669450.9678529237 0.02028879078620169 0.022940813709767884 3.2008681414308487e-07 6.494732216086568 0.050499048216717135 GVAPADS(ph)PEAPR ddPTM_A459_Selumetinib_30min_R1 2 GVAPADSPEAPR 12 0 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 GVAPADS(1)PEAPR;GVAPADS(1)PEAPR 132.14 0.0019254 34007000.0 5144.799999999999 5875.6 5030.6 5042.6 5422.5 4547.2 4773.6 4975.0 2741.5 4295.6 True False 5264.663829961861 5187.682020507665 4347.472151107814 4162.004571325288 4932.0358324201325 4501.459296527262 4413.5235087525925 4843.04683892251 4652.125268762218 4846.982102687295 1.0861735649989284 1.0702911441805152 0.8969441312146502 0.8586795831199301 1.0175477705365739 0.9287138266987893 0.9105714473972616 0.9991881002072189 0.9597983178404882 1.0 12.242871040075013 -5.24225378287265 19.645991223921374 0.943893982604273 1.078233273813738 0.5487294745409479 0.04776598277947216 38.53356130428232 39454.23309326555 0.01240128297130366 0.03253068682855259 5.72461411588691e-06 5.24225378287265 0.13433929120946486 GVAPADS(ph)PEAPR ddPTM_A459_Selumetinib_30min_R2 4 GVAPADSPEAPR 12 0 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 GVAPADS(1)PEAPR;GVAPADS(1)PEAPR;GVAPADS(1)PEAPR;GVAPADS(1)PEAPR 153.49 0.0004675 75770000.0 172645.0 166122.0 185569.0 199560.0 206061.0 159983.0 180640.0 166462.0 157198.0 164240.0 True False 163050.08205269332 178863.0232335805 173629.69257225058 172379.58373979863 180173.77497128712 182019.20606892172 189040.1179313696 166946.3768607326 188641.9924791037 159497.9644532324 1.0222706139958448 1.12141257630925 1.0886013070289802 1.0807635340722066 1.1296305604208337 1.1412008090065184 1.1852196269677129 1.0466991063681206 1.1827235107719312 1.0 17.2831784865651 -6.2548252729847675 22.997257976545747 1.1214770191067645 1.0820827059126183 0.07489742530419119 0.05812634628958377 435.705694857465 1514935.7995394687 0.016308833148180678 0.020530574652588958 5.561279557916907e-07 6.2548252729847675 -0.0393943131941461 GVAPADS(ph)PEAPRR ddPTM_A459_Selumetinib_30min_R1 3 GVAPADSPEAPRR 13 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 GVAPADS(1)PEAPRR;GVAPADS(1)PEAPRR;GVAPADS(1)PEAPRR 130.47 0.002304 37040500.0 8532.9 7505.9 9531.8 8899.4 8940.8 6590.8 7299.4 7760.5 5275.7 6361.799999999999 True False 8731.699967866882 6627.105738601755 8237.433914429588 7345.286852427775 8132.1062186264435 6524.5025359676 6748.800381219347 7554.666330343344 8952.4775781174 7178.398999179633 1.2163854320252696 0.9232010841636301 1.1475307955675051 1.023248617591083 1.1328579282867672 0.9089077573861857 0.9401539789012311 1.05241660866256 1.2471412607658772 1.0 12.809446399811014 -3.689065624129638 14.773649562750663 1.0528821439570553 1.0564140510184659 0.0 0.11565152278082398 0.0 0.0 0.025675483531106616 0.0 0.00020461354317777435 3.689065624129638 0.0035319070614105996 GVAPADS(ph)PEAPRR ddPTM_A459_Selumetinib_30min_R2 2 GVAPADSPEAPRR 13 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 GVAPADS(1)PEAPRR;GVAPADS(1)PEAPRR 85.28 0.014383000000000003 49858000.0 85178.0 63839.0 79382.0 88388.0 82348.0 67836.0 89736.0 82845.0 67303.0 74473.0 True False 80444.14775455014 68735.24602526173 74274.64854458667 76349.40192219554 72002.70803953937 77179.79324610342 93908.9018085106 83086.06523427195 80765.48060294073 72322.77098590818 1.1122934956436388 0.95039563733882 1.0269884233149584 1.055675838762759 0.9955745204172117 1.0671575797495594 1.2984693552022282 1.1488230345939174 1.1167365340395707 1.0 16.14216233400392 -7.0139581246633185 24.444600231210007 1.1576097749187184 1.0259287713311982 0.307541779436765 0.07835917463981822 499.78549342918876 875263.9857951945 0.027918205065691093 0.02255240448460912 9.683712235909865e-08 7.0139581246633185 -0.13168100358752022 GVDDLDFFIGDEAIEKPTYATK ddPTM_A459_Selumetinib_30min_R1 1 GVDDLDFFIGDEAIEKPTYATK 22 1 F8WDR7;B4DXW1;P61158 F8WDR7 ACTR3 Actin-related protein 3 0 103.17 0.00039405 0.0 746.58 812.24 1129.6 1042.3 971.49 1088.4 895.62 1009.8 503.88 674.24 False True 763.9738614082038 717.1425631998685 976.2065244486515 860.2818713941916 883.61890103049 1077.4516841881318 828.0626623322017 983.0168237073265 855.0475580608813 760.7852716537577 1.0041911822865799 0.9426346564793232 1.283156444822626 1.1307814483897054 1.161456371401253 1.4162362552655892 1.0884315104210676 1.292108115566555 1.1239013029290392 1.0 9.57134550653345 -5.253038089973804 24.823775967237598 1.199186716662864 0.9734128915664974 0.35867017718032224 0.11331515284090254 535.7413881686738 1582975.6888103469 0.027121579863722763 0.0692264941862947 5.584212160296136e-06 5.253038089973804 -0.22577382509636668 GVDEATIIDILT(ph)KR ddPTM_A459_Selumetinib_30min_R1 1 GVDEATIIDILTKR 14 1 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 1 GVDEATIIDILT(1)KR 101.08 0.010663 6432300.0 4658.8 1947.4 3625.5 2618.1 3557.9 2266.0 2676.5 4199.0 2687.3 3389.9 True False 4767.340975553241 1719.3975026783019 3133.177013445986 2160.897982823689 3236.0885731982635 2243.2060973633816 2474.6094501374882 4087.6288797257534 4560.1518273735965 3825.0266854222127 1.2463549584431237 0.44951255091401066 0.8191255306497661 0.5649367077775472 0.8460303258880555 0.5864550189708736 0.6469522054757474 1.0686536894773466 1.1921882387783236 1.0 11.901254097511035 -7.794259354401787 8.180339889210845 1.1001171669544643 0.7209553824732141 0.36554411558696887 0.21031452506530945 0.22936556535147412 48.69072103580365 0.10610388616305365 0.05163351346663388 1.6059818973548962e-08 7.794259354401787 -0.37916178448125015 GVDEATIIDILTK ddPTM_A459_Selumetinib_30min_R1 1 GVDEATIIDILTK 13 0 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 0 160.72 0.0050401000000000005 44441000.0 465.76 610.49 572.96 514.72 548.12 447.59 437.66 443.01 520.15 365.76 False True 476.61130178880353 539.0135469908988 495.15517904399746 424.83381449104684 498.5426427784457 443.0876509792043 404.6469538379123 431.25993570071614 882.6565597470977 412.7088588041031 1.1548366157437693 1.3060382288686168 1.1997687194764783 1.0293789566865077 1.2079765969237035 1.0736082871182584 0.9804658785625499 1.044949548576127 2.1386906069929084 1.0 8.688980595930623 GVDEATIIDILTKR ddPTM_A459_Selumetinib_30min_R1 2 GVDEATIIDILTKR 14 1 P04083;Q5T3N1;Q5T3N0 P04083 ANXA1 Annexin A1;Annexin 0 ; 167.22 0.00029557 12901200.0 2074.08 2739.86 5537.5 5017.0 3591.5 3723.1000000000004 3074.8 3051.5 2012.21 1918.88 False True 2122.402028542858 2419.0759174736436 4785.5379153102085 4140.875130753772 3266.6494591308256 3685.6489943043316 2842.8653604643196 2970.564307331063 3414.573403996364 2165.1869394740197 0.9802396226620712 1.117259610877433 2.210219278559264 1.9124792669217276 1.5087147440139186 1.7022313071958912 1.3129884115941164 1.3719666663298322 1.5770339926518553 1.0 11.080275875438174 -7.2731827006365775 23.542708355737727 1.3464944605891074 1.5928229250460249 0.10576455469677692 0.3576031319797663 967.1567012833299 1938917.044192979 0.1606286429832086 0.10942607058309431 5.331105773440492e-08 7.2731827006365775 0.24632846445691747 GVDEVT(ph)IVNILTNR ddPTM_A459_Selumetinib_30min_R2 1 GVDEVTIVNILTNR 14 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9 P07355 ANXA2 Annexin A2;Annexin 1 GVDEVT(1)IVNILTNR 135.61 0.0014075 2176900.0 9501.4 6461.7 8199.0 11091.0 9796.0 8045.2 11452.0 9289.7 7296.9 6810.9 True False 8973.350225117796 6957.291612359748 7671.485266396233 9580.386666957836 8565.338902648866 9153.3532729458 11984.5406917075 9316.731489007381 8756.48389242083 6614.251620156594 1.3566690141892954 1.051863765079296 1.1598417639597765 1.4484460551458456 1.294982319170688 1.3838834381582072 1.8119269389729935 1.4085843756858474 1.3238812786825185 1.0 12.691362214413546 -5.758579463630476 24.981095594241715 1.4131037724815703 1.175698685762179 0.14846373293284487 0.2005213506387828 112.56673007597608 983237.3197998981 0.05492253930928133 0.08999577006020941 1.7434943180360762e-06 5.758579463630476 -0.2374050867193913 GVDLLLEGVQGES(ph)SPTRR ddPTM_A459_Selumetinib_30min_R1 2 GVDLLLEGVQGESSPTRR 18 1 F5H7T0;F6RJM5;Q96S38-2;Q96S38 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 GVDLLLEGVQGES(0.496)S(0.496)PT(0.007)RR;GVDLLLEGVQGES(0.619)S(0.37)PT(0.011)RR 106.69 0.00084349 12217500.0 2769.2 3213.5 3281.2 3431.8999999999996 3306.4 2639.0 3052.7 2787.4 1669.08 2373.6 True False 2833.716972074789 2837.2619260843803 2835.631062341463 2832.583089741654 3007.336703792334 2612.4540560202868 2822.4323812571306 2713.4690972487647 2832.306855220007 2678.2746808219013 1.058038218546421 1.0593618146790267 1.0587528914216044 1.0576148555727671 1.1228634334359802 0.975424244095301 1.0538248378583002 1.0131407046031824 1.0575117165916816 1.0 11.387088214083773 -6.76609811456363 24.999999676222657 1.022916889035625 1.069201286692727 0.4379930755515319 0.028935950507607642 122.90704120517195 659547.4418642359 0.009681009832517325 0.0088120265259877 1.713570138925448e-07 6.76609811456363 0.046284397657101906 GVDLLLEGVQGES(ph)SPTRR ddPTM_A459_Selumetinib_30min_R2 4 GVDLLLEGVQGESSPTRR 18 1 F5H7T0;F6RJM5;Q96S38-2;Q96S38 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 GVDLLLEGVQGES(0.467)S(0.467)PT(0.065)RR;GVDLLLEGVQGES(0.477)S(0.477)PT(0.047)RR;GVDLLLEGVQGES(0.61)S(0.383)PT(0.007)RR;GVDLLLEGVQGES(0.492)S(0.492)PT(0.016)RR 110.57 0.00070235 7666700.0 29889.6 27526.300000000003 33455.4 33910.6 34982.8 25286.399999999998 27063.5 25890.800000000003 22436.999999999996 30798.3 True False 28228.455689549006 29637.478698995317 31302.915987485354 29291.91778095215 30587.94791379998 28769.37207291512 28322.00637530788 25966.13794154732 26925.026942159864 29909.073055406592 0.9438091122802689 0.9909193322070481 1.046602679043134 0.9793656168042667 1.0226979571428298 0.9618944732797244 0.9469369486256337 0.8681692640037697 0.9002294017029956 1.0 14.868295578569379 -7.217398854640389 2.3240591668838575 0.91412193276816 0.9975631839189338 0.36383729196131964 0.04100952713230809 0.2828290795441021 2.994706845970178 0.018851009850074513 0.012795373557340966 6.061793607141209e-08 7.217398854640389 0.08344125115077383 GVEEEEEDGEMRE ddPTM_A459_Selumetinib_30min_R1 6 GVEEEEEDGEMRE 13 1 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 ;;;;; 295.79 3.2462999999999996e-60 63199900.0 13208.279999999999 12653.419999999998 13726.37 14017.23 13537.84 11409.04 13827.310000000001 12588.18 7920.17 11001.62 False True 13516.007225161056 11171.951703984629 11862.404347553333 11569.383916495059 12313.344762299777 11294.275416179496 12784.304874268853 12254.300574228662 13439.950023670419 12413.785091853657 1.0887901735974723 0.8999633569712786 0.9555831891545988 0.931978750307775 0.9919089682308265 0.9098172179242235 1.0298474461796785 0.9871526277887915 1.0826633395232663 1.0 13.599655454779592 -7.2907863220727736 24.77533597833216 1.023845253928548 0.9597072342117714 0.23357120234328155 0.054730355649916435 917.9133440200048 774918.814181329 0.02166730405547346 0.014610780832711983 5.1193365088694283e-08 7.2907863220727736 -0.06413801971677668 GVEEEEEDGEMRE ddPTM_A459_Selumetinib_30min_R2 3 GVEEEEEDGEMRE 13 1 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 ;; 220.5 1.66e-07 52753300.0 61485.0 55934.0 63541.0 64561.0 65047.0 52636.0 54353.0 49634.0 53613.0 55777.0 False True 58067.90984395641 60223.95794384299 59452.84123820992 55767.680426063 56875.21433244186 59886.131217965405 56880.522198426275 49778.42672264898 64337.09807238118 54166.57308394992 1.072024803082152 1.1118288367718046 1.0975928114571156 1.0295589558459164 1.05000577098156 1.1055920249034592 1.0501037625228782 0.9189879272129698 1.1877638626440055 1.0 15.725115199337893 -1.5228788407332412 0.0830722118721627 0.9703465074883681 1.307518878333471 0.07265805434475148 0.06615939988185042 448.65696798914837 2.716438861048967 1.593052670807086 17.31187762382598 0.029999993406347736 1.5228788407332412 0.3371723708451029 GVEICIAT(ph)PGR ddPTM_A459_Selumetinib_30min_R2 3 GVEICIATPGR 11 0 P17844-2;P17844;J3KTA4;J3QSF1;J3KRZ1;A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 P17844-2;A0A1X7SBZ2 DDX5;DDX17 Probable ATP-dependent RNA helicase DDX5;Probable ATP-dependent RNA helicase DDX17 1 GVEICIAT(1)PGR;GVEICIAT(1)PGR;GVEICIAT(1)PGR 107.09 0.025127 13258500.0 61500.0 67395.0 72704.0 79094.0 78232.0 59794.0 55894.0 61319.0 43311.0 76094.0 True False 58082.07620400618 72563.97979091974 68026.30379413001 68321.26075523961 68403.79675704625 68030.08074411092 58493.181751859855 61497.42813809307 51974.410210450864 73896.96850404446 0.7859872655104558 0.9819615237254047 0.92055608195087 0.9245475442135399 0.9256644506777357 0.9206071929782554 0.7915504916640588 0.8322050198138676 0.7033361619916282 1.0 16.173227561053643 -7.253576260597249 23.83657980104518 0.8177900022501847 0.9150319062640611 0.16651305052790377 0.08282135238304368 439.74142312447435 1333053.8763934663 0.030024385091666234 0.02278480265885965 5.577296581581862e-08 7.253576260597249 0.09724190401387633 GVEPS(ph)PSPIKPGDIK ddPTM_A459_Selumetinib_30min_R2 2 GVEPSPSPIKPGDIK 15 1 Q92890;Q92890-1;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 GVEPS(0.916)PS(0.084)PIKPGDIK;GVEPS(0.566)PS(0.434)PIKPGDIK 139.21 0.0018726 49457100.0 104196.0 98082.0 93761.0 95002.0 91100.0 90492.0 115400.0 102342.0 70480.0 82188.0 True False 98405.20344963612 105604.57401666263 87728.5193392581 82062.56371240907 79655.2035556667 102956.45159541228 120766.32866076192 102639.79827636984 84577.96937573762 79815.01888993078 1.2329158699485143 1.3231165698563203 1.0991480119830637 1.0281594222959187 0.9979976784258552 1.2899383227283925 1.5130777432666551 1.2859709827033388 1.0596748651074706 1.0 16.284372625236145 -6.8154890968820885 24.999964801758995 1.2653148868112183 1.1385783308975326 0.05797440003138543 0.15860747800023323 213.0066497066253 98521.53759885413 0.05913919600259426 0.0521559082951021 1.5293641411692155e-07 6.8154890968820885 -0.1267365559136857 GVEPSPS(ph)PIKPGDIK ddPTM_A459_Selumetinib_30min_R1 2 GVEPSPSPIKPGDIK 15 1 Q92890;Q92890-1;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 GVEPS(0.086)PS(0.914)PIKPGDIK;GVEPS(0.315)PS(0.685)PIKPGDIK 142.4 0.0018114 45709000.0 8708.7 11278.4 6898.5 7180.200000000001 6273.0 7459.4 8158.799999999999 7420.4 4477.25 8471.7 True False 8911.595765819633 9957.919684814085 5961.721590748074 5926.31285904689 5705.6082575881 7384.365208593302 7543.375147312434 7223.586887143842 7597.566244598082 9559.125216346014 0.9322605954131543 1.0417187200128037 0.6236681135375847 0.6199639323599351 0.5968755642861089 0.7724938256866964 0.7891281865848282 0.7556744705877037 0.7947972301488755 1.0 13.222662883643794 -10.348954152347146 16.0152958674123 0.9999999313151176 0.7640960214412086 0.21295892203438804 0.1324843551354045 0.0 0.0 0.14171539453486842 0.03437103179078485 4.4776057092397093e-11 10.348954152347146 -0.23590390987390897 GVEPSPS(ph)PIKPGDIK ddPTM_A459_Selumetinib_30min_R2 1 GVEPSPSPIKPGDIK 15 1 Q92890;Q92890-1;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 GVEPS(0.12)PS(0.88)PIKPGDIK 70.615 0.028165 65190000.0 101560.0 76001.0 86445.0 95586.0 85876.0 96163.0 125670.0 110790.0 68491.0 78128.0 True False 95915.70177689225 81830.0323182683 80883.22281419941 82567.02190495263 75087.48913881925 109408.5803691998 131513.90401038097 111112.38055772823 82191.11379843448 75872.24163907784 1.264173823058512 1.0785239838771539 1.0660449865045332 1.088237544077341 0.9896569221719896 1.4420106485011133 1.7333599373007718 1.4644668215588879 1.083283056132905 1.0 16.2112845422066 -6.768428968643933 24.997373923273738 1.3979493034509713 1.0940398981949744 0.24941827925574322 0.2042411184740599 193.18525942938467 690897.8430420432 0.07197733008309941 0.06483679186386383 1.704398060608856e-07 6.768428968643933 -0.30390940525599697 GVEPSPS(ph)PIKPGDIKR ddPTM_A459_Selumetinib_30min_R1 2 GVEPSPSPIKPGDIKR 16 2 Q92890;Q92890-1;Q92890-3 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 GVEPS(0.007)PS(0.993)PIKPGDIKR;GVEPS(0.003)PS(0.997)PIKPGDIKR 97.621 0.0085054 155952000.0 7491.799999999999 7498.9 10173.1 10636.099999999999 8519.3 7471.9 7312.9 6946.6 5219.3 6533.1 True False 7666.344363494837 6620.925301855969 8791.648896838336 8778.704799324332 7748.730819204573 7396.73946994239 6761.282065350433 6762.353602263142 8856.770897410417 7371.687022782931 1.0399714936080762 0.8981560504933731 1.1926237331654033 1.1908678125092496 1.051147558931402 1.0033984686384585 0.9171960291387873 0.9173413875770114 1.2014578033546035 1.0 12.847779104916649 -6.673657781065938 4.3338873587893225 0.9969408728970176 1.0799916868958477 0.08783193191830507 0.10695923571289802 0.5308394731141896 18.251080856913735 0.03851435708401216 0.03796526137840151 2.120031036705476e-07 6.673657781065938 0.08305081399883008 GVEPSPS(ph)PIKPGDIKR ddPTM_A459_Selumetinib_30min_R2 3 GVEPSPSPIKPGDIKR 16 2 Q92890;Q92890-1;Q92890-3 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 GVEPS(0.021)PS(0.979)PIKPGDIKR;GVEPS(0.042)PS(0.958)PIKPGDIKR;GVEPS(0.05)PS(0.95)PIKPGDIKR 63.727 0.023687 158722900.0 291479.0 345520.0 304299.0 317816.0 295501.0 218557.0 237580.0 222133.0 161479.2 283010.0 True False 275279.76406288624 372020.27297809254 284720.73363569967 274528.9125368195 258377.52256754186 248661.24288708976 248627.940755839 222779.37025390205 193779.55210582598 274838.76595171174 1.0016045702637595 1.353594612790014 1.0359555088590529 0.9988725993081098 0.9401058168516807 0.904753163281117 0.904631993579545 0.8105820497427341 0.7050663010904088 1.0 18.06822598478579 -6.036511006418814 0.9593665802687755 0.8445540911658348 1.1841377531141013 0.5262498736212001 0.11078219313029668 0.43657745677711307 0.821271563670267 0.04748494664975545 0.09930332496823581 9.193671747879426e-07 6.036511006418814 0.3395836619482665 GVESSDVHPAPTVQQMS(ph)SPKPAEER ddPTM_A459_Selumetinib_30min_R1 1 GVESSDVHPAPTVQQMSSPKPAEER 25 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 GVESSDVHPAPT(0.029)VQQMS(0.486)S(0.486)PKPAEER 116.35 3.3353e-08 13913000.0 1383.3 1317.0 1271.1 1598.7 1759.9 1274.0 1230.7 1210.5 615.95 1016.0 True False 1415.5281985667552 1162.8050277433106 1098.4916016525158 1319.5170563157374 1600.7173557355802 1261.1847166994478 1137.8673081577454 1178.3936077418498 1045.2221627919346 1146.4134966780634 1.2347448827744085 1.0142980967275286 0.9581984204090322 1.1509957446761332 1.396282720304622 1.100113284041015 0.992545282705514 1.0278957907914155 0.9117322552644846 1.0 10.162911784263034 -7.208532243690746 4.474607580232975 0.984446406883468 1.1420946054901095 0.32057779012335197 0.114700415511604 0.3133240047555831 13.50997162770191 0.05057998807628661 0.03778670161809963 6.186823924904755e-08 7.208532243690746 0.1576481986066416 GVESSDVHPAPTVQQMS(ph)SPKPAEER ddPTM_A459_Selumetinib_30min_R2 1 GVESSDVHPAPTVQQMSSPKPAEER 25 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 GVESSDVHPAPT(0.055)VQQMS(0.782)S(0.163)PKPAEER 95.523 4.2111e-06 8758800.0 26110.0 26716.0 25536.0 31024.0 33260.0 25933.0 24198.0 26819.0 20210.0 31644.0 True False 24658.910726611408 28765.03129452049 23893.04156149458 26798.477680614902 29081.581451827376 29505.035353664716 25323.25494742735 26897.038849875542 24252.564714580854 30730.35549901413 0.8024284238235544 0.9360461611139939 0.7775061880511308 0.8720523158762231 0.9463470558536282 0.960126717525649 0.8240469248147733 0.875259606116123 0.7892054719431706 1.0 14.90737683615485 -5.9958345349132305 24.98392574790313 0.8937631827841762 0.8444622503702224 0.12587429562942543 0.07016271603650165 309.5990689881459 1856899.9878697228 0.019753477809885584 0.02916887923628469 1.0096374821052185e-06 5.9958345349132305 -0.049300932413953835 GVESSDVHPAPTVQQMSS(ph)PKPAEER ddPTM_A459_Selumetinib_30min_R2 1 GVESSDVHPAPTVQQMSSPKPAEER 25 1 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 GVESSDVHPAPT(0.002)VQQMS(0.247)S(0.752)PKPAEER 85.595 4.1228e-05 32319000.0 59922.0 52066.0 65853.0 68646.0 66155.0 47575.0 58078.0 53774.0 47259.0 66390.0 True False 56591.77512677167 56059.294781423254 61616.08967532511 59296.29637904491 57844.01746679619 54128.02440714918 60778.74207937373 53930.47343723509 56712.12052678758 64473.148198064264 0.8777572789360203 0.8694983314481046 0.9556860708280888 0.9197053042436233 0.8971799746632024 0.8395436847734747 0.9426985307535913 0.836479603439844 0.8796238761688125 1.0 15.976410810978662 -11.28430434910265 7.034837727316335 1.0022729502947505 0.891626748997477 0.4314025363206526 0.03756476866217845 0.0013812191205779217 4.6841596610848765e-05 0.037514771300693646 0.008923742622595716 5.196317163483645e-12 11.28430434910265 -0.11064620129727354 GVGDDQLGEES(ph)EERDDHLLPM ddPTM_A459_Selumetinib_30min_R1 1 GVGDDQLGEESEERDDHLLPM 21 1 H0YF90;F5GX30;P20645 H0YF90 M6PR Cation-dependent mannose-6-phosphate receptor 1 GVGDDQLGEES(1)EERDDHLLPM 64.069 0.0061298 3598300.0 1300.2 1453.7 1941.1 1694.9 1665.9 1414.0 1316.7 1649.8 844.58 1099.7 True False 1330.4921302512075 1283.5001281932048 1677.5092816990777 1398.9175322133885 1515.2196391385332 1399.776443809278 1217.380258918749 1606.0419446943429 1433.1905743174161 1240.8572069851045 1.0722362917840385 1.0343656957207101 1.351895505990493 1.1273799469741739 1.2211071754340241 1.1280721391063984 0.9810800566461654 1.2943003720762707 1.1550004031484182 1.0 10.277121389955306 -6.971031988681392 24.530574315073686 1.1210424444905993 1.1641887265548394 0.04218609121190042 0.1142584336189184 791.0990722123315 669911.7245300596 0.04103474624396896 0.03618883423978236 1.0689761391098194e-07 6.971031988681392 0.043146282064240093 GVGDDQLGEESEERDDHLLPM ddPTM_A459_Selumetinib_30min_R2 1 GVGDDQLGEESEERDDHLLPM 21 1 H0YF90;F5GX30;P20645 H0YF90 M6PR Cation-dependent mannose-6-phosphate receptor 0 65.02199999999999 0.029313 2041600.0 17584.0 11727.0 17924.0 19290.0 14631.0 12394.0 15638.0 14665.0 16375.0 14280.0 False True 16606.75167432919 12626.423191751821 16770.789354175628 16662.668722893923 12792.92297720044 14101.160998469917 16365.197986109131 14707.672722078549 19650.457555727935 13867.699296104216 1.1975131072386638 0.9104915618770951 1.209341866742594 1.201545286432255 0.9224978638521742 1.0168349267878405 1.18009466723197 1.0605704960887277 1.416994783067458 1.0 13.759440838485595 GVGQADWT(ph)PDLGLR ddPTM_A459_Selumetinib_30min_R1 1 GVGQADWTPDLGLR 14 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 GVGQADWT(1)PDLGLR 164.63 0.00060606 6529100.0 1462.6 1842.1 1577.1 2067.6 1607.9 1468.3 1682.0 1665.2 1103.9 1578.7 True False 1496.6757342758153 1626.4260756309438 1362.9384823901996 1706.5324736588605 1462.4657288978008 1453.530235109733 1555.1253858140306 1621.033486668094 1873.237674333984 1781.3415228402166 0.8401958384091767 0.9130343927747939 0.7651191334815435 0.9580040951035158 0.8209912081126408 0.81597504828394 0.8730079919399727 0.9100071299542137 1.0515881712268436 1.0 10.798748424387894 -8.074638720121248 2.914257270751265 1.0255486220090193 0.8554266082114504 0.6248141073893895 0.05202592511256649 0.16984155499231848 2.6645143508660403 0.039657271195020986 0.013277038640729499 8.420953706815315e-09 8.074638720121248 -0.17012201379756886 GVGS(ph)PEPGPTAPYLGR ddPTM_A459_Selumetinib_30min_R1 2 GVGSPEPGPTAPYLGR 16 0 Q9C0B5-2;Q9C0B5 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5 1 GVGS(1)PEPGPTAPYLGR;GVGS(1)PEPGPTAPYLGR 147.51 0.00031541 11298700.0 2643.9 1925.77 3278.8 2049.41 3035.8 2075.53 2508.63 2912.3 1155.54 1887.83 True False 2705.4977258661484 1700.2999531338164 2833.5569691592086 1691.51901569027 2761.2124260140204 2054.6520526304607 2319.4020193904007 2835.056343516387 1960.86698269761 2130.151369521406 1.2700964657145508 0.7982061638726796 1.3302139039047918 0.7940839509777718 1.2962517431962586 0.9645568301055016 1.088843756634776 1.3309177855061802 0.9205294096720317 1.0 11.056740237319115 GVGS(ph)PEPGPTAPYLGR ddPTM_A459_Selumetinib_30min_R2 2 GVGSPEPGPTAPYLGR 16 0 Q9C0B5-2;Q9C0B5 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5 1 GVGS(1)PEPGPTAPYLGR;GVGS(1)PEPGPTAPYLGR 188.19 8.448700000000002e-07 24837000.0 70749.0 25851.0 44839.0 64063.0 34260.0 26692.0 83172.0 59355.0 37798.0 28571.0 True False 66817.0538106867 27833.688575933855 41954.10755701189 55337.5088851609 29955.952511713967 30368.580714148717 87039.66280219151 59527.71322325079 45358.656164360604 27746.080993626994 2.408161852696744 1.0031574759090116 1.5120732750202937 1.9944261280672897 1.079646257739771 1.0945178427585533 3.1370074506083823 2.1454458104163874 1.6347770402162038 1.0 14.759996391360422 GVGS(ph)PPGR ddPTM_A459_Selumetinib_30min_R2 1 GVGSPPGR 8 0 O96028-3;O96028;O96028-6;H0Y9L4;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 GVGS(1)PPGR 104.01 0.014949 8118200.0 19673.0 25952.0 28148.0 24904.0 30775.0 25132.0 25822.0 21820.0 19769.0 26140.0 True False 18579.65341725875 27942.434951167677 26336.988325225175 21512.032238203745 26908.769368009274 28593.704874418774 27022.77416532231 21883.492587504552 23723.352392011348 25385.27028012355 0.7319068582778281 1.100734191238703 1.03749095576291 0.8474218316693474 1.0600150824109449 1.126389617242224 1.0645060646244493 0.8620547406437953 0.9345321964362353 1.0 14.63170400025193 -2.7290963472964025 19.62240773799577 0.9831648608221506 0.4059080810417094 0.0 0.12193544351997083 0.0 0.0 0.027844254340690155 0.0 0.0018659656844407855 2.7290963472964025 -0.5772567797804412 GVGSGPHPPDT(ph)QQPSPSK ddPTM_A459_Selumetinib_30min_R1 1 GVGSGPHPPDTQQPSPSK 18 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 GVGSGPHPPDT(0.988)QQPS(0.011)PSK 116.74 0.0024191 35656000.0 2763.7 2777.5 2962.9 3372.6 2879.4 2760.7 2905.0 2526.0 1238.9 2280.0 True False 2828.088832775928 2452.3090087752803 2560.554454044716 2783.6387215427885 2618.9587783993597 2732.929864515045 2685.8735111710816 2459.0022743956324 2102.3228143240985 2572.6602090806955 1.0992857987205806 0.953219162063994 0.9952944601882324 1.0820079199411583 1.0179963794500513 1.0622972496984433 1.0440063175427436 0.955820852561918 0.8171785791623584 1.0 11.329045206542974 -7.93078398475424 4.377158291312224 0.9016498231710323 1.0330931757729125 0.4553349203094016 0.05727909565131543 0.16992071396497604 6.281891091070067 0.032975211293477025 0.014623198770902093 1.1727785529105783e-08 7.93078398475424 0.13144335260188023 GVGSGPHPPDTQQPS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 4 GVGSGPHPPDTQQPSPSK 18 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 GVGSGPHPPDT(0.026)QQPS(0.973)PS(0.002)K;GVGSGPHPPDT(0.174)QQPS(0.822)PS(0.004)K;GVGSGPHPPDT(0.01)QQPS(0.503)PS(0.487)K;GVGSGPHPPDT(0.103)QQPS(0.772)PS(0.125)K 181.86 1.0157e-09 229683000.0 9840.830000000002 11231.51 12994.3 13118.559999999998 12324.25 10794.2 11178.380000000001 11204.23 5202.73 10186.98 True False 10070.102192078126 9916.519587812661 11229.745432580665 10827.64976186989 11209.523763523064 10685.620148349437 10335.185796834634 10907.057423931808 8828.652817635331 11494.578112588088 0.8760741014974728 0.862712792995226 0.9769602087685675 0.9419788752413781 0.9752009733395216 0.9296226484943597 0.8991357225643831 0.9488871463657403 0.7680710619528337 1.0 13.488665895101269 -10.478628346156736 14.82912397919397 0.9999961882509693 0.9138361477132371 0.1697304415123715 0.05960135938658119 0.0 0.0 0.05749285724326448 0.013944066066619817 3.321786026433867e-11 10.478628346156736 -0.08616004053773219 GVGSGPHPPDTQQPS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 5 GVGSGPHPPDTQQPSPSK 18 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 GVGSGPHPPDT(0.048)QQPS(0.815)PS(0.136)K;GVGSGPHPPDTQQPS(0.965)PS(0.035)K;GVGSGPHPPDT(0.001)QQPS(0.968)PS(0.031)K;GVGSGPHPPDT(0.005)QQPS(0.896)PS(0.099)K;GVGSGPHPPDT(0.079)QQPS(0.862)PS(0.059)K 168.46 7.5237e-08 772740000.0 433811.0 416114.0 447978.0 543738.0 552396.0 395397.0 457455.0 465705.0 366940.0 496579.0 True False 409701.52130302653 448028.6057826057 419155.5832015678 469679.94639963185 482999.07599710254 449859.34769340156 478727.5639298858 467060.12444838695 440338.2531602317 482241.4740028107 0.8495775319827399 0.9290544881255783 0.869181946800214 0.9739517891339523 1.0015710013243022 0.9328508059652696 0.9927133806145748 0.9685191955216708 0.9131073889295246 1.0 18.87939620618429 -5.76687711500318 24.98988749062682 0.9684914702699617 0.8872496335491853 0.5968139051505308 0.032456880792571446 89.1675772410464 409784.63833054627 0.00875351180410131 0.013412617766202194 1.7104992377909698e-06 5.76687711500318 -0.08124183672077645 GVHIHQAGGS(ph)PPASSTSSSSLTNDVAK ddPTM_A459_Selumetinib_30min_R1 2 GVHIHQAGGSPPASSTSSSSLTNDVAK 27 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 GVHIHQAGGS(0.999)PPASST(0.001)SSSSLTNDVAK;GVHIHQAGGS(0.995)PPASST(0.004)SSSSLTNDVAK 179.07 2.6727999999999996e-26 42585000.0 3743.7 4636.0 5104.799999999999 4751.6 5193.200000000001 4530.0 4923.1 3985.8 1736.6100000000001 3493.0 True False 3830.920926027877 4093.214964782072 4411.596198659243 3921.8222585787566 4723.475976933927 4484.4323129109125 4551.746603389449 3880.0836362969562 2946.900333023949 3941.3605747012543 0.9719793085204471 1.038528418601317 1.1193079432966193 0.9950427483727549 1.1984379219838204 1.1377878851520256 1.1548668326887246 0.9844528463603098 0.7476860533744282 1.0 11.944478024885733 -8.003633274632906 6.743927405603072 0.8701853870661137 1.088877532462777 0.49173777721027967 0.08750782894112086 0.10578637005997972 25.830734630937183 0.052621379649247305 0.022617571578976654 9.916689729508665e-09 8.003633274632906 0.21869214539666337 GVHIHQAGGS(ph)PPASSTSSSSLTNDVAK ddPTM_A459_Selumetinib_30min_R2 2 GVHIHQAGGSPPASSTSSSSLTNDVAK 27 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 GVHIHQAGGS(0.869)PPAS(0.022)S(0.022)T(0.022)S(0.011)S(0.009)S(0.004)S(0.031)LT(0.009)NDVAK;GVHIHQAGGS(1)PPASSTSSSSLTNDVAK 153.88 1.0795e-14 81732000.0 77415.0 57715.0 90836.0 96364.0 104323.0 73921.0 74018.0 84376.0 65059.0 87171.0 True False 73112.58421679896 62141.55491702535 84991.71065475878 83239.05696282776 91217.01208054689 84102.94676197326 77459.98366388453 84621.52019080117 78072.61790034216 84654.1467325422 0.8636621717751423 0.7340639214444683 1.0039875651134147 0.983283869434237 1.0775256216182714 0.9934888012951048 0.9150170033443603 0.999614590152989 0.9222539109277914 1.0 16.369293118951504 -5.270586521986671 24.936527677222347 0.9876587190889217 0.7988630452774667 0.6798011840730389 0.05161738000756173 308.2266209040626 840274.7661445311 0.013536468657626907 0.02883937802914312 5.363070154406955e-06 5.270586521986671 -0.188795673811455 GVHIHQAGGSPPASST(ph)SSSSLTNDVAK ddPTM_A459_Selumetinib_30min_R1 2 GVHIHQAGGSPPASSTSSSSLTNDVAK 27 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 GVHIHQAGGS(0.227)PPAS(0.025)S(0.025)T(0.677)S(0.043)S(0.003)SSLTNDVAK;GVHIHQAGGS(0.182)PPAS(0.038)S(0.038)T(0.479)S(0.182)S(0.021)S(0.021)S(0.028)LT(0.011)NDVAK 138.25 4.5152e-12 15803000.0 3771.0 4282.200000000001 4081.8999999999996 4380.299999999999 3475.7000000000003 3984.2 3852.8999999999996 4240.0 2374.0 3966.8999999999996 True False 3858.856962911322 3780.838033259228 3527.6004002717345 3615.3628334145387 3161.3235486846766 3944.122565364161 3562.2726510124135 4127.541426538986 4028.504609900239 4476.090255878159 0.8621043683924237 0.8446742172578174 0.7880985857332 0.8077055257468764 0.7062689463272362 0.8811534933158688 0.7958446875226235 0.9221309648791273 0.9000052232212845 1.0 12.128023411770636 -8.199140249075004 1.0036688118966492 0.9920855181400673 0.8070843622361814 0.5933561729391787 0.049622674345567414 0.34510115755537446 0.6977976268278843 0.04628972985468894 0.016213671767003352 6.322076561561411e-09 8.199140249075004 -0.18500115590388588 GVIS(ph)TPVIR ddPTM_A459_Selumetinib_30min_R1 3 GVISTPVIR 9 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DG79;A0A494C0Y9 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 GVIS(0.5)T(0.5)PVIR;GVIS(0.5)T(0.5)PVIR;GVIS(0.5)T(0.5)PVIR 112.11 0.0098852 15402800.0 11935.7 14236.8 14421.999999999998 14189.5 13521.0 12137.1 14001.8 12661.699999999999 7759.2 10974.7 True False 12213.778587170695 12569.948837491247 12463.571614375405 11711.570194903456 12298.027937326442 12015.011793605076 12945.632953086155 12325.870585002036 13166.79569045407 12383.409647630662 0.9863017484451527 1.0150636371700967 1.0064733356180364 0.9457468119165588 0.9931051533677918 0.9702506931040538 1.0454013330297172 0.9953535363630941 1.0632609325795255 1.0 13.596120980406624 -7.25859719219359 24.99681703282316 1.025616745294944 0.9868733216358024 0.36700004657160523 0.02562481895781929 284.5397947882449 2502501.2210811134 0.009955080309952576 0.007360718115727908 5.513188071216865e-08 7.25859719219359 -0.03874342365914163 GVIST(ph)PVIR ddPTM_A459_Selumetinib_30min_R1 1 GVISTPVIR 9 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DG79;A0A494C0Y9 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 GVIS(0.004)T(0.996)PVIR 134.66 0.006615 4163300.0 3334.7 3674.1 4847.4 4308.1 3304.3 3616.1 4146.3 3994.1 2476.7 3250.7 True False 3412.392021803336 3243.934663957249 4189.149704862247 3555.771208052687 3005.426648421548 3579.725317156103 3833.541252794717 3888.1634933347536 4202.7790089890195 3667.959009499391 0.9303244700842676 0.8843977415112898 1.1420928352833444 0.9694141070943932 0.8193730193380033 0.9759447441711377 1.0451428826948437 1.0600346086924828 1.145808608576196 1.0 11.840761801151656 -7.308665585637044 3.198342787462256 1.0728200823105045 0.95267975660901 0.29398033021017733 0.08376238092646322 0.3523463264448567 7.271171176016881 0.039831835064465734 0.026371050656611137 4.9128602939502285e-08 7.308665585637044 -0.12014032570149447 GVIST(ph)PVIR ddPTM_A459_Selumetinib_30min_R2 2 GVISTPVIR 9 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DG79;A0A494C0Y9 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 GVIS(0.071)T(0.929)PVIR;GVIS(0.07)T(0.93)PVIR 116.54 0.018279 9902500.0 114423.0 107645.0 100699.0 118780.0 106563.0 123920.0 114397.0 109348.0 106775.0 111964.0 True False 108063.82773156093 115901.02536677122 94220.13597278117 102601.95909307103 93175.60325469273 140988.85516624132 119716.68717335523 109666.18457646403 128132.98354276943 108731.30840259201 0.9938611915846755 1.0659397653676013 0.866540993178512 0.9436284783143944 0.8569344434787611 1.296672110706251 1.1010323423138477 1.008598040321657 1.1784368773374838 1.0 16.730407888339876 -6.740935524828145 24.99999865600713 1.1164906289281737 0.9476013390770063 0.4424370789488602 0.09628274765736204 239.31940808164174 291797.4233745929 0.03206115832651687 0.03202632577921111 1.815785213455194e-07 6.740935524828145 -0.16888928985116747 GVLDLDRPGEPAGEES(ph)PGPLQER ddPTM_A459_Selumetinib_30min_R1 2 GVLDLDRPGEPAGEESPGPLQER 23 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 GVLDLDRPGEPAGEES(1)PGPLQER;GVLDLDRPGEPAGEES(1)PGPLQER 123.76 5.7377e-06 13951700.0 2442.4 2535.37 3002.2 3006.6000000000004 2943.0299999999997 2253.23 2823.74 2894.57 1519.49 2224.53 True False 2499.3031679168953 2238.5277017384637 2594.5177299041634 2481.5537508718935 2676.8334561341485 2230.5645519691516 2610.7430183938827 2817.796600711546 2578.4635508413294 2510.0700942571407 0.9957105077006099 0.8918188009410788 1.0336435368240244 0.9886392242788397 1.0664377310651802 0.8886463199065725 1.0401076146706318 1.1225967781371768 1.027247628160133 1.0 11.293511936975662 -7.504147420656257 24.509950011110103 1.0612237692389874 0.9793325617464332 0.2438855878473707 0.05953475515206124 729.5059390339683 954562.5408447282 0.024602805460346752 0.01626276245979927 3.1322223153424007e-08 7.504147420656257 -0.08189120749255419 GVLDLDRPGEPAGEES(ph)PGPLQER ddPTM_A459_Selumetinib_30min_R2 2 GVLDLDRPGEPAGEESPGPLQER 23 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 GVLDLDRPGEPAGEES(1)PGPLQER;GVLDLDRPGEPAGEES(1)PGPLQER 112.55 7.3029e-06 18570000.0 36712.0 28350.0 38808.0 39964.0 40551.0 33471.0 34378.0 36884.0 32261.0 34955.0 True False 34671.6940097801 30524.353840382377 36311.135530955595 34520.83425825468 35456.620849460385 38081.32643051371 35976.64511871467 36991.32633352509 38714.101447654306 33945.758326002986 1.021385166205612 0.8992096611080932 1.0696810830453798 1.0169410247586421 1.0445081388062571 1.1218287146451171 1.0598274097519862 1.0897186617035788 1.140469482986883 1.0 15.0509436940975 -5.758308381196305 1.0299066534747148 1.0848296163475517 0.9621423347345073 0.36266381154613914 0.05201585167989773 0.6017713789658584 1.2096962154146274 0.01922056530142756 0.05706340603217957 1.7445829301180937e-06 5.758308381196305 -0.12268728161304443 GVLHTFS(ph)PSPK ddPTM_A459_Selumetinib_30min_R2 1 GVLHTFSPSPK 11 0 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 GVLHTFS(0.991)PS(0.009)PK 73.36 0.03833 8176800.0 84166.0 84887.0 92972.0 105970.0 105440.0 83533.0 82503.0 85995.0 81334.0 102170.0 True False 79488.3906631933 91397.55994527462 86990.2827402598 91536.7031915538 92193.68455444011 95038.91251292457 86339.55297659311 86245.2312127613 97603.0726618367 99220.08663046014 0.8011320425393653 0.9211598482641918 0.876740644908429 0.9225622179960123 0.9291836732395782 0.9578596002127258 0.870182197060159 0.869231565317787 0.9837027559283846 1.0 16.598344596418023 -1.5229732311828912 0.018524684731616305 1.636206696489582 7.5291223032387826e-06 0.431457922696025 0.043037221688387146 4049.310388145244 5.8061838085098785 194.5332847936873 336.12244991074107 0.029993473855024225 1.5229732311828912 -1.6361991673672789 GVLNS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 GVLNSPVK 8 0 G5EA31;P53992-2;P53992 G5EA31 SEC24C Protein transport protein Sec24C 1 GVLNS(1)PVK 80.755 0.045381 2414300.0 25781.0 29168.0 30976.0 33865.0 33856.0 22902.0 22119.0 24269.0 20442.0 29166.0 True False 24348.195229520054 31405.09181009782 28983.037884118756 29252.528579616523 29602.706603519797 26056.54261634326 23147.577327966996 24339.61877205076 24530.971197202474 28323.901797631326 0.8596342200125918 1.1087840945954759 1.0232713731037775 1.0327859766150882 1.0451493164686587 0.9199489110826644 0.8172453602385665 0.8593314207185337 0.8660872846005261 1.0 14.78973239907887 -6.904807058130651 4.4738994052581305 0.8731602884268439 1.0202667358836275 0.4044354224903812 0.07355305034662592 0.18480148503019012 6.574928516245686 0.02542552685369613 0.02225871545775404 1.2450676289792277e-07 6.904807058130651 0.14710644745678358 GVMAVTAVTATAAS(ph)DR ddPTM_A459_Selumetinib_30min_R2 1 GVMAVTAVTATAASDR 16 0 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;A0A087WT54 Q7Z4V5-2 HDGFRP2 Hepatoma-derived growth factor-related protein 2 1 GVMAVTAVTAT(0.035)AAS(0.965)DR 148.85 0.00027623 4336300.0 12312.0 7017.8 11563.0 8295.6 13343.0 13564.0 17847.0 20070.0 18546.0 8062.8 True False 11627.748328841037 7556.042694216421 10819.049168842503 7165.724969291806 11666.733052066535 15432.317878267384 18676.920863159605 20128.400377232625 22255.718218536196 7830.006014329768 1.4850241886865712 0.965011097103634 1.381742127533805 0.9151621283786685 1.4900030767173278 1.9709203096427452 2.385300960047642 2.570674957387702 2.842362851038147 1.0 12.93479770033171 -6.793981848250454 2.270086519887333 2.3229841853072126 1.1845599555472837 0.4688787148060449 0.48582291968916425 0.2291068764436628 2.422949671348523 0.18092733150814855 0.16348923722398384 1.607008418049395e-07 6.793981848250454 -1.138424229759929 GVNAIVY(ph)MIDAADREKIEAS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GVNAIVYMIDAADREKIEASR 21 2 Q9NVJ2-2;Q9NVJ2 Q9NVJ2-2 ARL8B ADP-ribosylation factor-like protein 8B 2 GVNAIVY(1)MIDAADREKIEAS(1)R 49.655 0.045508 0.0 471.85 535.06 837.83 864.61 637.57 656.29 481.45 704.23 415.68 506.64 True False 482.84318693972637 472.41492645735434 724.0572878707629 713.6220942397887 579.9019060721262 649.6883184636426 445.1338388823814 685.5515327385733 705.3785999340072 571.6721790915099 0.8446155062278021 0.8263738270561055 1.2665603021322822 1.2483064951207925 1.0143958850572277 1.13647006488249 0.7786522681404214 1.1992039455690118 1.2338865275112407 1.0 9.159044271784456 -5.2391082117048855 24.127534046732876 1.1074805377978525 0.8354945225832333 0.3768021533196183 0.141025395522579 563.8311810913999 609182.994072326 0.037224635476922924 0.09829157733750825 5.766227703223042e-06 5.2391082117048855 -0.2719860152146192 GVNLPGAAVDLPAVSEK ddPTM_A459_Selumetinib_30min_R1 2 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 204.82 2.04e-07 12694200.0 2470.5 2416.1 1798.38 2200.2 2385.3999999999996 1734.56 1997.3899999999999 1991.1599999999999 1849.12 2135.16 False True 2528.0578432438137 2133.2218887855843 1554.1698737942345 1815.9763728691346 2169.6409911765745 1717.1119012544693 1846.7252641920852 1938.3479686007936 3137.821585618673 2409.228584219621 1.049322534110097 0.8854377300510741 0.6450902516988231 0.7537584373536527 0.9005542294274862 0.712722699913783 0.7665213987116388 0.8045512913539702 1.302417548160982 1.0 11.234355565608821 -8.244975757764843 24.375798473798774 1.151208745611816 0.8072653241686127 0.5320713257803644 0.12605678334943266 378.9792949871463 561114.1090134291 0.08579302957654382 0.032198086923272175 5.688846849922041e-09 8.244975757764843 -0.34394342144320333 GVNLPGAAVDLPAVSEK ddPTM_A459_Selumetinib_30min_R2 2 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 204.82 2.04e-07 12234800.0 43262.0 34639.9 42628.1 43358.5 44915.0 35749.7 39543.9 45346.0 37454.6 37540.8 False True 40857.67123150755 37296.66894516621 39885.454455966006 37452.997502415565 39272.376154805395 40673.896671534654 41382.76970475133 45477.94935256561 44946.56656896292 36456.89956128776 1.1207116272414126 1.0230345803944931 1.094044061232209 1.0273226180260684 1.0772275379255587 1.1156707553575063 1.1351148946493017 1.2474442396318575 1.232868595789479 1.0 15.15390425365964 -7.121730845324895 1.9618461269724976 1.1781766543174064 1.0651397607249071 0.23421157017993366 0.06919431279106106 0.3837314227842791 2.9106898117068205 0.031517175272111606 0.02227362692277453 7.555603422807341e-08 7.121730845324895 -0.11303689359249924 GVNTDSGS(ph)VCR ddPTM_A459_Selumetinib_30min_R2 1 GVNTDSGSVCR 11 0 V9GYE4;A0A494C194;K7ES25;A0A494C165;P12955-3;P12955-2;P12955 V9GYE4 PEPD Xaa-Pro dipeptidase 1 GVNT(0.001)DS(0.137)GS(0.862)VCR 85.271 0.042392 0.0 5559.2 4953.3 5941.0 6567.4 6316.1 5151.0 4157.3 4450.9 3616.5 4946.3 True False 5250.241919240832 5333.202182630197 5558.762528071715 5672.908790603092 5522.615051349581 5860.50349387757 4350.62268753367 4463.851382113841 4339.901053452832 4803.487466969209 1.093006269995226 1.1102771099755184 1.1572347312855698 1.1809979373553876 1.1497094744860676 1.2200517924064225 0.9057216694017364 0.9292938542692476 0.9034896173448579 1.0 12.229866508080944 -7.26865204568937 24.99932292149932 0.9287340931271512 1.1514568737608397 0.8695519282434039 0.04119785040994437 190.89066601313746 661629.7805529637 0.01733489456614852 0.01196527903454457 5.387012140636057e-08 7.26865204568937 0.22272278063368856 GVNTFS(ph)PEGR ddPTM_A459_Selumetinib_30min_R1 1 GVNTFSPEGR 10 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 1 GVNT(0.011)FS(0.989)PEGR 112.64 0.008112300000000001 12466000.0 2990.2 3574.9 3237.0 3249.1 4614.0 3123.7 4183.3 3452.9 1609.9 2388.9 True False 3059.865842083648 3156.349046074078 2797.433179568241 2681.7056781606707 4196.664514667863 3092.278414092674 3867.750313005849 3361.3178754001087 2731.8827175561914 2695.538584856521 1.135159355267222 1.1709530198552454 1.0378012005779333 0.9948682215963951 1.5568927628209945 1.147183880603687 1.434871062404667 1.2469930478027367 1.0134830689880867 1.0 11.396357845606628 GVNTFS(ph)PEGR ddPTM_A459_Selumetinib_30min_R2 1 GVNTFSPEGR 10 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 1 GVNT(0.008)FS(0.992)PEGR 114.76 0.005150399999999999 0.0 36061.0 41140.0 41194.0 41915.0 49074.0 28997.0 40176.0 46853.0 39653.0 36685.0 True False 34056.8739836206 44295.30571405045 38543.62288863597 36206.104692591995 42908.88539287362 32991.073541442034 42044.26360723369 46989.33447306831 47584.70799739116 35625.808730923185 0.9559607261367024 1.2433487769669114 1.0819016960358887 1.0162886396783777 1.2044325987645224 0.9260441998838275 1.1801630645015868 1.3189689201997423 1.3356807800993906 1.0 15.120635144278378 -7.5156054965944685 24.371250899318845 1.2463081454148512 1.0806711995547935 0.21441981680893396 0.12622379965811031 324.20811231668785 1086373.970485221 0.05405477549940248 0.03286055707893225 3.050664887214838e-08 7.5156054965944685 -0.16563694586005773 GVPAGNS(ph)DTEGGQPGR ddPTM_A459_Selumetinib_30min_R1 4 GVPAGNSDTEGGQPGR 16 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 GVPAGNS(0.601)DT(0.399)EGGQPGR;GVPAGNS(0.584)DT(0.416)EGGQPGR;GVPAGNS(0.92)DT(0.08)EGGQPGR;GVPAGNS(0.553)DT(0.447)EGGQPGR 220.78 7.679300000000001e-11 193314000.0 2712.4700000000003 2922.7 2825.8 3345.5299999999997 3071.1 2437.6099999999997 2697.0 2681.21 1729.4 2079.7 True False 2775.665273452155 2580.508925273632 2442.0718810083235 2761.295988875957 2793.319547246743 2413.0898565727957 2493.5631186328433 2610.0956010024975 2934.665489621514 2346.6497529934745 1.1828204315157864 1.0996566155566412 1.0406631317234816 1.176697112704418 1.1903436137768235 1.028312748203931 1.0626055786348008 1.1122646648367365 1.2505766938069665 1.0 11.196386814496526 -6.751713325814402 24.99819159371194 1.0960093238535975 1.1326421769493693 0.08597433057587245 0.07510531827914196 752.0861477022803 1933032.221173577 0.025776449717121945 0.025484484933757927 1.7712777782818044e-07 6.751713325814402 0.0366328530957718 GVPAGNS(ph)DTEGGQPGR ddPTM_A459_Selumetinib_30min_R2 6 GVPAGNSDTEGGQPGR 16 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 GVPAGNS(0.555)DT(0.445)EGGQPGR;GVPAGNS(0.997)DT(0.003)EGGQPGR;GVPAGNS(0.989)DT(0.011)EGGQPGR;GVPAGNS(0.547)DT(0.453)EGGQPGR;GVPAGNS(0.944)DT(0.056)EGGQPGR;GVPAGNS(0.937)DT(0.063)EGGQPGR 219.85 9.0374e-11 184939000.0 23770.600000000002 30761.300000000003 38348.450000000004 49743.299999999996 45897.799999999996 33811.409999999996 27309.199999999997 32339.799999999996 36611.8 38557.5 True False 22449.52521325122 33120.592796830846 35881.1524776354 42968.176728021215 40131.70803246192 38468.62481807941 28579.131912153207 32433.903463857914 43935.18301916335 37444.2447905839 0.5995454131550972 0.8845309334469387 0.958255472324506 1.1475241914566914 1.0717723980523126 1.0273574759812785 0.7632449812244577 0.8661919514000738 1.1733494229856045 1.0 15.192456371927978 -4.742274591051835 2.0543246112040796 0.9962183717900952 0.4606800123564152 0.5260268607831207 0.11546406051511801 0.719883134445557 3.1066087865987515 0.03342543968358426 0.7559837276699344 1.8101951999332466e-05 4.742274591051835 -0.53553835943368 GVPAGNS(ph)DTEGGQPGRK ddPTM_A459_Selumetinib_30min_R1 2 GVPAGNSDTEGGQPGRK 17 1 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 GVPAGNS(0.988)DT(0.012)EGGQPGRK;GVPAGNS(0.995)DT(0.005)EGGQPGRK 171.87 1.1512e-06 27223000.0 2633.2299999999996 2679.1099999999997 3508.19 3572.73 3204.88 2628.5600000000004 3031.8599999999997 2612.52 1523.25 2072.47 True False 2694.579135626355 2365.4385557155506 3031.7970671082844 2948.819773948161 2914.9991698675194 2602.1190729415225 2803.1643592355103 2543.227482939064 2584.8439962217944 2338.4917120673085 1.152272262382428 1.0115231726112983 1.296475438190914 1.2609921851471098 1.2465296134364137 1.1127339299574246 1.1987061338598524 1.0875503512863691 1.105346656942693 1.0 11.191362600320552 -8.322283650631135 0.9312692047302318 1.0052926576948575 1.1868963830842196 0.3459430743604075 0.07855610674847589 0.660380325599777 1.2293150512634012 0.07931679087489611 0.028041178136328004 4.761199171663183e-09 8.322283650631135 0.1816037253893621 GVPAGNS(ph)DTEGGQPGRK ddPTM_A459_Selumetinib_30min_R2 1 GVPAGNSDTEGGQPGRK 17 1 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 GVPAGNS(1)DTEGGQPGRK 144.41 0.00088689 3928100.0 6241.6 7270.5 5205.0 6066.1 8355.6 5267.9 5581.3 4490.2 4203.4 7188.8 True False 5894.71685910447 7828.1239716578475 4870.11596677551 5239.886715393828 7305.894827988243 5993.5054077650275 5840.841509136138 4503.2657386073715 5044.197452808965 6981.240665254482 0.84436522700648 1.121308424535239 0.6976003550506424 0.7505666924609341 1.0465037918474231 0.8585157990032636 0.8366480671846636 0.6450523559544437 0.7225359638314506 1.0 12.76926773120521 -7.530943858548041 24.617584377229964 0.7584465058944809 0.8861551770457268 0.07229913510958819 0.14489724360828285 331.4975006571009 1011828.2939750804 0.06776972683236925 0.039220035794208505 2.9448022851713182e-08 7.530943858548041 0.12770867115124585 GVPGCCYS(ph)SLPR ddPTM_A459_Selumetinib_30min_R2 1 GVPGCCYSSLPR 12 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 GVPGCCY(0.001)S(0.592)S(0.407)LPR 90.434 0.024414 8842800.0 29263.0 21067.0 21125.0 28051.0 29649.0 19695.0 23442.0 27436.0 23425.0 24334.0 True False 27636.679609070467 22682.77115891837 19765.84049916091 24230.405409325962 25924.22755457698 22407.80747659071 24532.09944944177 27515.834217725678 28110.654549186384 23631.414192675056 1.1694890277720624 0.9598566964286576 0.836422244475223 1.0253472437902837 1.0970239590067623 0.9482211810893814 1.0381138957416223 1.1643752673191543 1.189546013623668 1.0 14.528418347740171 -7.6195383613129755 4.987098835578136 1.1314636490439542 1.0006516628662345 0.20888340349677748 0.09574692796416294 0.2923901045137478 11.967748739687396 0.0477402177487905 0.02679372085031769 2.4013841438059012e-08 7.6195383613129755 -0.13081198617771972 GVPGCCYSS(ph)LPR ddPTM_A459_Selumetinib_30min_R1 1 GVPGCCYSSLPR 12 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 GVPGCCYS(0.157)S(0.843)LPR 117.95 0.0046415 16401000.0 1250.0 1593.5 1313.0 1303.9 1308.1 1127.2 1434.0 1210.1 657.91 1174.6 True False 1279.1225679234024 1406.9322792019477 1134.7018117927405 1076.1983422343721 1189.7825859638128 1115.8613914157127 1325.8322254799757 1178.0042170412326 1116.4252181547886 1325.3713515728866 0.9651050374714992 1.0615381700625026 0.8561387798567784 0.8119975891716628 0.8976975279809967 0.8419235786947276 1.0003477319066405 0.8888106836195261 0.8423489890813387 1.0 10.372180925100933 -5.26604833867027 24.993252310298207 0.8878061324279417 1.0133216061012378 0.36203079874508926 0.06397102602274587 355.0936384789219 1925595.3411095364 0.016464274526776557 0.03620202610958248 5.419405669450431e-06 5.26604833867027 0.12551547367329607 GVPGCCYSS(ph)LPR ddPTM_A459_Selumetinib_30min_R2 2 GVPGCCYSSLPR 12 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 GVPGCCY(0.015)S(0.437)S(0.548)LPR;GVPGCCYS(0.159)S(0.841)LPR 100.02 0.01383 14816200.0 73779.0 69310.0 53344.0 65981.0 58058.0 52594.0 53473.0 58580.0 49981.0 51173.0 True False 69678.65854073768 74625.85413322395 49911.905116555776 56994.273976426346 50764.23499489461 59838.34609920342 55959.60045473936 58750.45810155897 59978.596585822146 49695.502526578515 1.4021119618112652 1.501662129149655 1.0043545709163826 1.1468698590168043 1.021505617490124 1.2040998290982214 1.1260495942225484 1.1822087536017494 1.2069220258663036 1.0 15.600827672459774 -5.254466079183227 24.999994255218027 1.1198844416959417 1.4518870792524181 0.749801052097989 0.0785310670530426 251.31208833194069 900973.7244478124 0.0195633319671491 0.049375229689159986 5.565881051901406e-06 5.254466079183227 0.3320026375564764 GVPHPEDDHS(ph)QVEGPESLR ddPTM_A459_Selumetinib_30min_R2 1 GVPHPEDDHSQVEGPESLR 19 0 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 GVPHPEDDHS(1)QVEGPESLR 148.33 2.437e-05 8646800.0 29903.0 29136.0 31822.0 39647.0 43623.0 27825.0 32460.0 26326.0 30040.0 30174.0 True False 28241.110971193433 31370.637512994024 29774.607165173915 34247.01020511021 38142.688745431966 31657.64117979874 33969.45431826977 26402.6043014961 36048.83938772929 29302.798218532804 0.9637684005663357 1.0705679805402817 1.0161011567264833 1.168728322452509 1.3016739377916577 1.0803623921409866 1.159256329888164 0.9010267246353814 1.2302183265531923 1.0 14.838750818369073 -5.747218651478308 24.80122556159394 1.1235882268434372 1.0221880110943096 0.157800014836329 0.10902339918903334 424.7197914231092 740712.7110465415 0.0297832070805664 0.05126470486153595 1.789704576003436e-06 5.747218651478308 -0.10140021574912761 GVPPPEDLRS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 GVPPPEDLRSPSR 13 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 GVPPPEDLRS(0.856)PS(0.144)R 66.387 0.040179 3276000.0 21693.0 18545.0 24296.0 27895.0 27415.0 26163.0 27222.0 26861.0 20081.0 25504.0 True False 20487.389903959447 19967.3418684265 22732.821811484668 24095.652878440957 23970.882606790386 29766.71576593262 28487.87693936966 26939.161062922078 24097.761110019695 24767.633252649994 0.8271839983647777 0.8061869159940872 0.9178439287917181 0.972868607696412 0.9678309736852083 1.2018393304797401 1.1502058613663306 1.0876760321876837 0.9729537281258545 1.0 14.596168393559605 -5.873249904059916 1.2093220143309078 1.085424290651666 0.8125960661064333 0.6669164909058642 0.06991629608482061 0.2950551477954404 0.866853695226623 0.02705844451188562 0.06117188680260959 1.3389060252322655e-06 5.873249904059916 -0.2728282245452327 GVQKPAGPS(ph)TSPDGNSR ddPTM_A459_Selumetinib_30min_R2 2 GVQKPAGPSTSPDGNSR 17 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 GVQKPAGPS(0.481)T(0.481)S(0.038)PDGNSR;GVQKPAGPS(0.535)T(0.346)S(0.119)PDGNS(0.001)R 83.948 0.0069906000000000005 27422000.0 60194.0 50649.0 54418.0 55340.0 66994.0 47940.0 51190.0 51607.0 42780.0 52118.0 True False 56848.65845567394 54533.61543779637 50916.805125838524 47802.59653317523 58577.61478604101 54543.29984400902 53570.43643106067 51757.16782600125 51337.19537307122 50613.21792117364 1.1231978678813022 1.0774579779283835 1.005998180260692 0.9444686288792042 1.1573580418710254 1.0776493193725836 1.0584277908291206 1.0226018015019165 1.0143041182053496 1.0 15.627226581446662 -9.2052820643313 0.008371727686006037 2.805035141151041e-08 2.051620283304721 0.12842708572259032 0.05604335411110032 9914.502031842003 30.64939399524129 3845.9597296386873 3663.1117929308693 6.233298654986151e-10 9.2052820643313 2.0516202552543694 GVQKPAGPST(ph)SPDGNSR ddPTM_A459_Selumetinib_30min_R1 1 GVQKPAGPSTSPDGNSR 17 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 GVQKPAGPS(0.129)T(0.435)S(0.435)PDGNSR 197.51 8.117600000000002e-07 8047600.0 2913.1 3969.3 4078.2 4174.0 3306.8 3387.8 3287.2 2803.9 1643.5 2910.5 True False 2980.969562094133 3504.5725107224916 3524.402839949089 3445.089255683922 3007.700523862958 3353.7218078762858 3039.243857460097 2729.5314636492135 2788.8994635092877 3284.0910256707716 0.9077000420490091 1.0671362283591659 1.0731745290857868 1.0490236807550932 0.9158395733713376 1.0212024519604452 0.925444463537467 0.8311375788043847 0.8492150314072547 1.0 11.681278399738785 -7.413193065895289 3.6414560495396233 0.879379910874012 1.0094387690763307 0.35886169294610815 0.06801660813049258 0.23934344126787122 5.754121992557295 0.031340698388770655 0.01984873208713443 3.861952555346164e-08 7.413193065895289 0.13005885820231866 GVQKPAGPSTS(ph)PDGNSR ddPTM_A459_Selumetinib_30min_R1 2 GVQKPAGPSTSPDGNSR 17 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 GVQKPAGPS(0.013)T(0.053)S(0.934)PDGNSR;GVQKPAGPST(0.003)S(0.997)PDGNSR 254.89 1.818e-30 24506000.0 4284.0 5266.9 6196.7 6482.4 6275.9 4932.700000000001 5287.0 5276.299999999999 3720.6000000000004 3783.3 True False 4383.808864787089 4650.248899484618 5355.222176036617 5350.370529718609 5708.245953100139 4883.081516533259 4888.197333411881 5136.355384162182 6313.5864581275655 4268.923407462714 1.026912044644216 1.089325915605628 1.2544666804456814 1.2533301769634386 1.3371628882170326 1.143867212046228 1.1450655977726338 1.203196893901415 1.4789645668250866 1.0 12.059656562809833 -5.1333336209727145 3.621571958614968 1.233245641951588 1.0378179705663597 0.245555599243665 0.119844399542497 0.318091611814367 7.335462513242187 0.030384203109136955 0.09912599591293206 7.356417672335273e-06 5.1333336209727145 -0.19542767138522832 GVQVETIS(ph)PGDGR ddPTM_A459_Selumetinib_30min_R1 2 GVQVETISPGDGR 13 0 P62942;Q1JUQ3;A0A087WTS4;A0A087WV48;A0A087WZM5 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 GVQVET(0.067)IS(0.933)PGDGR;GVQVET(0.234)IS(0.766)PGDGR 135.61 0.0015246 4989300.0 5761.1 7000.3 6986.0 7270.3 7148.4 5984.0 6633.4 6953.9 3467.5 5745.4 True False 5895.322420850812 6180.701621648821 6037.339571351168 6000.678585433355 6501.828482152528 5923.806393037285 6133.037297419024 6769.459982549396 5884.094243820168 6482.878054935183 0.9093680878915984 0.9533885365842527 0.9312745851751997 0.9256195372771593 1.0029231503441467 0.9137618111646729 0.9460361964930317 1.0442059722835675 0.9076361137690717 1.0 12.662418720268477 -1.522878857984021 0.09839204704975099 1.0223632856047988 0.7336948792759918 0.1874810771031209 0.040099223369033085 220.50982158307423 1.54724071518114 0.5288116923590529 8.58820249304291 0.029999992214706374 1.522878857984021 -0.2886684063288071 GVQVETIS(ph)PGDGR ddPTM_A459_Selumetinib_30min_R2 1 GVQVETISPGDGR 13 0 P62942;Q1JUQ3;A0A087WTS4;A0A087WV48;A0A087WZM5 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 GVQVET(0.003)IS(0.997)PGDGR 115.58 0.003976 6630000.0 31493.0 24349.0 28164.0 28728.0 34434.0 25361.0 22190.0 26843.0 26500.0 28749.0 True False 29742.745136467736 26216.49000562506 26351.95890264466 24815.19684143583 30108.093076134213 28854.24754576374 23221.878968650828 26921.108685902127 31800.74047186505 27918.941671127453 1.0653249498789699 0.9390216260502813 0.9438738478363132 0.8888301402591711 1.0784109738396954 1.033500763949213 0.8317607179453324 0.9642596414656633 1.1390381786839716 1.0 14.768956633605793 -8.232215643930918 23.459420221665997 1.069519065723164 0.9650115105032495 0.2090098774406559 0.07871532738137639 435.63856720907677 349711.1823217958 0.0536193963030575 0.020255327293334718 5.858471965929689e-09 8.232215643930918 -0.1045075552199144 GVQVETISPGDGR ddPTM_A459_Selumetinib_30min_R2 1 GVQVETISPGDGR 13 0 P62942;Q1JUQ3;A0A087WTS4;A0A087WV48;A0A087WZM5 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 146.5 0.0082898 4647100.0 14925.0 9930.2 15070.0 18758.0 21467.0 13221.0 12912.0 16536.0 16864.0 14223.0 False True 14095.528249508812 10691.814409374427 14100.412606975397 16203.12804064513 18770.12354258505 15042.072741711387 13512.433584642622 16584.11702231783 20237.271219529513 13812.345034207998 1.020502182257935 0.7740766960928657 1.0208558048654275 1.1730903043991487 1.358938217666768 1.089031059132813 0.978286710270949 1.200673526562303 1.46515824571493 1.0 13.753670658016684 -5.600038041156825 3.5457323018780356 1.1840877247241983 0.8956884263533132 0.36850369472537636 0.15055984663838112 0.23955334572821352 5.958149014089574 0.04287602803852346 0.081486150406471 2.5116664174757984e-06 5.600038041156825 -0.28839929837088507 GVQVPAS(ph)PDTVPQPSLR ddPTM_A459_Selumetinib_30min_R1 2 GVQVPASPDTVPQPSLR 17 0 Q92613;F2Z2B6;F2Z3N8 Q92613 JADE3 Protein Jade-3 1 GVQVPAS(0.699)PDT(0.299)VPQPS(0.001)LR;GVQVPAS(0.847)PDT(0.153)VPQPSLR 179.74 8.036099999999999e-08 20982900.0 3577.0 3887.8 4307.7 4591.3 3901.0 3557.2999999999997 3395.6000000000004 3153.1 2215.53 3039.1 True False 3660.3371403696087 3432.614568610816 3722.7380005023538 3789.515644375083 3548.155238777491 3521.5167917699714 3139.4671581867565 3069.469545287753 3759.592594091105 3429.19808834085 1.0674032371634123 1.0009962913141652 1.0856001620785714 1.105073415635947 1.03468949514497 1.0269213679265137 0.9155105879887289 0.895098348422577 1.0963474541974068 1.0 11.743655528921852 -6.993389826567583 3.5206349645320785 0.9678444063528113 1.0589850719854685 0.30557899660961385 0.057180371894677465 0.2728139484232123 7.2335265536437285 0.022274345163259095 0.01829104940208694 1.0153369083310642e-07 6.993389826567583 0.09114066563265721 GVQVPAS(ph)PDTVPQPSLR ddPTM_A459_Selumetinib_30min_R2 2 GVQVPASPDTVPQPSLR 17 0 Q92613;F2Z2B6;F2Z3N8 Q92613 JADE3 Protein Jade-3 1 GVQVPAS(0.617)PDT(0.383)VPQPSLR;GVQVPAS(0.983)PDT(0.017)VPQPSLR 182.09 7.0943e-08 12341000.0 76797.0 63058.0 62947.0 75804.0 81680.0 58381.0 56710.0 61300.0 58537.0 66873.0 True False 72528.9301827489 67894.3458365725 58897.05855151158 65479.36443080614 71418.62817153528 66422.45282004778 59347.127368733185 61478.372851238724 70246.03566043639 64942.20273307958 1.1168227613228903 1.0454580069546853 0.9069150117002609 1.008271380937514 1.099725989663064 1.0227933458471097 0.9138453096926379 0.9466628827470231 1.0816700497387841 1.0 15.986868698854627 -7.030045796733269 24.58300807064112 0.9792740113711179 1.030737167910927 0.10728773995768848 0.06669516021932843 1361.5486445844026 1113994.1390677684 0.02682674585514205 0.020813273844780694 9.331558935027226e-08 7.030045796733269 0.05146315653980904 GVQVPVS(ph)PGTIPQPVAR ddPTM_A459_Selumetinib_30min_R1 2 GVQVPVSPGTIPQPVAR 17 0 Q6IE81-2;Q6IE81;Q6IE81-3;D6RCS1;D6RC05;D6RBB3;D6RFK0;D6RGE7 Q6IE81-2 JADE1 Protein Jade-1 1 GVQVPVS(0.895)PGT(0.105)IPQPVAR;GVQVPVS(0.899)PGT(0.101)IPQPVAR 201.75 4.1451000000000005e-08 28988000.0 6325.299999999999 7541.7 8027.1 8941.5 7757.9 6906.799999999999 6357.5 6134.299999999999 4007.6 5687.1 True False 6472.667183108719 6658.714257958793 6937.063909704119 7380.034877742644 7056.199314768486 6837.323862872645 5877.948656547386 5971.598436985395 6800.60449647692 6417.094682045096 1.008660071857614 1.0376524872836523 1.0810287604317086 1.1500585924642557 1.0995940786897833 1.0654858937960416 0.9159828470341524 0.930576644551281 1.0597637768233148 1.0 12.6477045545169 -7.1498059993401295 6.616544641608453 0.9711599893131139 1.078054045980715 0.4689352456957234 0.050524028397153975 0.22061734531691926 11.496757771384758 0.020684769658607147 0.01599022733097461 7.082620965528338e-08 7.1498059993401295 0.10689405666760121 GVQVPVS(ph)PGTIPQPVAR ddPTM_A459_Selumetinib_30min_R2 2 GVQVPVSPGTIPQPVAR 17 0 Q6IE81-2;Q6IE81;Q6IE81-3;D6RCS1;D6RC05;D6RBB3;D6RFK0;D6RGE7 Q6IE81-2 JADE1 Protein Jade-1 1 GVQVPVS(0.5)PGT(0.5)IPQPVAR;GVQVPVS(0.964)PGT(0.036)IPQPVAR 232.62 1.2839e-16 27085000.0 99189.0 101920.0 118572.0 121036.0 129384.0 99324.0 100198.0 87856.0 91595.0 104685.0 True False 93676.47246502723 109736.93627554772 110943.20661143232 104550.68800125385 113129.62521236438 113004.97942649889 104857.40553857027 88111.64641465618 109916.55937813144 101662.47204570506 0.9214459434245558 1.0794242365679694 1.0912896802426255 1.028409853679835 1.1127963243064163 1.1115702495970639 1.0314268719673554 0.8667076910646364 1.081191094081556 1.0 16.63342769163345 -7.533774685623452 24.904946227683393 0.9741830818253375 1.0620719291851826 0.17636175119243214 0.07124241594807229 305.1073021329054 697376.1805129293 0.032268998408865074 0.01865201244001991 2.9256698378512354e-08 7.533774685623452 0.08788884735984503 GVS(ph)MPNMLEPK ddPTM_A459_Selumetinib_30min_R1 2 GVSMPNMLEPK 11 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 GVS(1)MPNMLEPK;GVS(1)MPNMLEPK 217.46 1.7711e-05 114542000.0 5868.799999999999 8204.599999999999 8468.4 9621.6 7638.1 7250.8 7166.2 7558.3 3977.7 6168.799999999999 True False 6005.531621303095 7244.001617784941 7318.437793591502 7941.368179800781 6947.235203616084 7177.863535199656 6625.647764459281 7357.829331181508 6749.866380286516 6960.625569200432 0.8627861909246399 1.040711290352752 1.0514051820247776 1.1408986305684887 0.9980762698048867 1.0312095463029163 0.951875330541644 1.0570643770494759 0.9697212288150523 1.0 12.765001255251427 -9.958984887789635 15.232802748638038 0.999980061415835 1.017131904876452 0.0 0.07038006777189895 0.0 0.0 0.0678579494624067 0.016457970186548706 1.0990440823692752e-10 9.958984887789635 0.017151843460617044 GVS(ph)MPNMLEPK ddPTM_A459_Selumetinib_30min_R2 4 GVSMPNMLEPK 11 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 GVS(1)MPNMLEPK;GVS(1)MPNMLEPK;GVS(1)MPNMLEPK;GVS(1)MPNMLEPK 153.38 0.00056162 51062500.0 227317.0 178757.0 182251.0 196111.0 176152.0 152520.0 145903.0 168789.0 126050.0 162374.0 True False 214683.6311620499 192467.08710565194 170525.16907988494 169400.34348965497 154022.2109411393 173528.2455612905 152687.77860130992 169280.14804547685 151263.52213126744 157685.8407216821 1.361464226461333 1.2205730471726963 1.0814234702332244 1.074290137366545 0.9767662729654392 1.1004681508948575 0.9683036720513555 1.07352789109492 0.959271431340813 1.0 17.266693594693827 -4.652877902857561 0.9089095133634431 1.0163255387659813 1.6289167352594227 0.8662670640817376 0.04381649391589548 0.8230715142511623 0.4565400188928909 0.013966759999573974 0.5295798353911492 2.2239350377768396e-05 4.652877902857561 0.6125911964934414 GVS(ph)PSQAQGLGSNLVTEVR ddPTM_A459_Selumetinib_30min_R1 2 GVSPSQAQGLGSNLVTEVR 19 0 U3KQS6;A0A0A0MQU7;F5H0K0;A0A0A0MTK8;P20823-3;P20823-2;P20823;P20823-7;P20823-6 U3KQS6 HNF1A Hepatocyte nuclear factor 1-alpha 1 GVS(0.998)PS(0.002)QAQGLGSNLVTEVR;GVS(0.741)PS(0.259)QAQGLGSNLVTEVR 299.6 3.376799999999998e-100 32885000.0 1741.85 1720.5 1439.7 1742.58 1700.71 1596.45 1673.18 1519.83 937.23 1459.38 True False 1782.4317159499033 1519.0630601612506 1244.196647706024 1438.2711152778365 1546.8810807847372 1580.391162460623 1546.970685515053 1479.5191712964013 1590.4108574291508 1646.7056385649923 1.0824227926389978 0.9224860986600041 0.7555671266118141 0.8734233256960277 0.9393792336393246 0.9597290040482532 0.9394336481796148 0.8984721595935724 0.9658136950421211 1.0 10.685366969819176 -6.387476541240172 6.584171641007122 0.9458833364957194 0.8987275448395822 0.05783966481526481 0.07826795440790228 0.7646808401657511 37.76257875046318 0.025936250297824166 0.02940176297968376 4.0975424241516955e-07 6.387476541240172 -0.04715579165613726 GVS(ph)PSQAQGLGSNLVTEVR ddPTM_A459_Selumetinib_30min_R2 4 GVSPSQAQGLGSNLVTEVR 19 0 U3KQS6;A0A0A0MQU7;F5H0K0;A0A0A0MTK8;P20823-3;P20823-2;P20823;P20823-7;P20823-6 U3KQS6 HNF1A Hepatocyte nuclear factor 1-alpha 1 GVS(0.555)PS(0.428)QAQGLGS(0.015)NLVT(0.002)EVR;GVS(0.618)PS(0.382)QAQGLGSNLVTEVR;GVS(0.937)PS(0.063)QAQGLGSNLVTEVR;GVS(0.843)PS(0.157)QAQGLGSNLVTEVR 139.81 0.00012717 40180200.0 35678.399999999994 35521.2 42417.0 47423.5 43569.7 32343.399999999998 30985.5 38545.9 32610.4 39108.3 True False 33695.53735995143 38245.56182134004 39687.93640013771 40964.33748989944 38096.084767939974 36798.40976584736 32426.38714660343 38658.06218738272 39133.391210706 37979.141763433625 0.8872116587003434 1.007014904643341 1.0449929766014174 1.0786009263995524 1.0030791376286166 0.9689110405669284 0.853794626234119 1.0178761391760243 1.0303916674700557 1.0 15.21291968399347 -6.726834812576605 5.551501274992952 0.9676941480073377 1.0111625557117903 0.04222734413040685 0.06447197175040906 0.5149305940902615 40.866591555105586 0.02320070704906545 0.022578290477646933 1.8757078130605686e-07 6.726834812576605 0.043468407704452594 GVS(ph)QEKEAQISSAIVSSVQSK ddPTM_A459_Selumetinib_30min_R1 2 GVSQEKEAQISSAIVSSVQSK 21 1 Q12872;Q12872-2 Q12872 SFSWAP Splicing factor, suppressor of white-apricot homolog 1 GVS(0.995)QEKEAQIS(0.004)S(0.001)AIVSSVQSK;GVS(1)QEKEAQISSAIVSSVQSK 108.13 6.9594e-05 59159000.0 4697.2 4115.700000000001 8955.8 9017.8 7043.4 5755.0 5216.7 4845.4 3547.4 3372.0 True False 4806.635620839845 3633.831930662982 7739.651550688068 7443.010515071034 6406.325713613272 5697.109925121922 4823.200119010734 4716.884251922641 6019.678708155064 3804.8290460614485 1.2632987087331589 0.9550578716340821 2.0341653874566936 1.9562010342555687 1.6837354940413816 1.4973366361937495 1.2676522547060156 1.2397099041296749 1.5821154210295747 1.0 11.893615918432952 -7.125409002199509 3.8831762353365757 1.293071745193739 1.5902347678568172 0.1683991329855853 0.3200274166224945 0.5185135522450461 13.622250124500523 0.1403062824839543 0.10719777669300974 7.491883196287827e-08 7.125409002199509 0.29716302266307815 GVS(ph)QEKEAQISSAIVSSVQSK ddPTM_A459_Selumetinib_30min_R2 1 GVSQEKEAQISSAIVSSVQSK 21 1 Q12872;Q12872-2 Q12872 SFSWAP Splicing factor, suppressor of white-apricot homolog 1 GVS(0.951)QEKEAQIS(0.037)S(0.011)AIVS(0.001)SVQSK 88.27799999999998 0.00049184 3110200.0 30952.0 45635.0 41807.0 46301.0 34412.0 22023.0 21865.0 17635.0 10646.0 38539.0 True False 29231.811750673158 49135.057760347445 39117.183136019914 39994.723926319944 30088.85691281672 25056.468345110803 22881.76582467554 17686.314930368586 12775.497474093407 37426.27893365268 0.7810504432592341 1.3128491306189287 1.0451795970784268 1.0686267795208941 0.8039499990409585 0.6694886336290493 0.6113823355305806 0.4725640762129184 0.3413509928876748 1.0 15.191763996560258 -6.556847999808256 1.6366683450039974 0.5664821347310071 1.0797865955418 0.5060859877487092 0.1993636636572832 0.2699234593836669 1.4764559730958688 0.07630804703470165 0.0815210337164886 2.7742909181962476e-07 6.556847999808256 0.513304460810793 GVS(ph)SSFDMPK ddPTM_A459_Selumetinib_30min_R1 1 GVSSSFDMPK 10 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 GVS(0.863)S(0.02)S(0.117)FDMPK 121.9 0.0046331 5171300.0 3559.6 3871.6 4572.1 5334.4 3914.3 3075.0 4227.6 4224.4 1139.9 2770.4 True False 3642.531754224115 3418.3112721419907 3951.2339327475947 4402.847179089679 3560.252256125795 3044.0682918766124 3908.7087283397136 4112.355189214926 1934.327044998015 3126.007825981209 1.1652343682411532 1.0935069463778555 1.2639872171488755 1.4084568638940271 1.138913417469863 0.9737878026332589 1.250383538983248 1.3155293966431825 0.6187850935372683 1.0 11.610105674800735 -8.254778790592798 24.991871424671228 0.8093925379704091 1.1986144850989542 0.5467569882889363 0.14268570430585512 360.33155371236626 1352049.4419735179 0.10279530230503088 0.03686347473175006 5.5618748116472575e-09 8.254778790592798 0.3892219471285451 GVSMS(ph)LPSSPLLPR ddPTM_A459_Selumetinib_30min_R1 2 GVSMSLPSSPLLPR 14 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 GVS(0.036)MS(0.92)LPS(0.043)S(0.002)PLLPR;GVS(0.191)MS(0.562)LPS(0.234)S(0.014)PLLPR 134.88 0.00060824 17889500.0 1798.04 2225.57 2744.0 2522.0 2492.8 2274.7 2453.2 2368.3 1307.87 1725.0900000000001 True False 1839.9308336231968 1964.999229760578 2371.3798717130862 2081.5800438032716 2267.326680139586 2251.8185832623494 2268.1531489173485 2305.484990677423 2219.3598669546027 1946.522105299567 0.9452401432348666 1.0094923784377816 1.2182650611862094 1.0693842305391745 1.164809109522364 1.1568420297573747 1.165233696931627 1.184412437136239 1.1401667933347441 1.0 10.92668301312585 -5.084837633452363 4.875749734578783 1.1438259168662945 0.9582387083085427 0.5482378905438637 0.05905660760405965 0.12908419846364635 5.173680085624296 0.01400270781493543 0.041467708823254866 8.225501133510203e-06 5.084837633452363 -0.1855872085577518 GVSMS(ph)LPSSPLLPR ddPTM_A459_Selumetinib_30min_R2 1 GVSMSLPSSPLLPR 14 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 GVSMS(0.863)LPS(0.096)S(0.041)PLLPR 134.04 0.00067695 3822700.0 10362.0 7816.0 11240.0 10880.0 9944.6 9413.6 8472.1 7458.7 6370.7 8923.8 True False 9786.121522372554 8415.462067598892 10516.830637186686 9398.125230953141 8695.270442148001 10710.237951847388 8866.069437147666 7480.403582145745 7645.018012230592 8666.146707183103 1.1292356168239268 0.9710731138008053 1.2135532656595356 1.08446412788781 1.0033606325797322 1.2358708332239519 1.0230693913592361 0.8631752767288682 0.8821703890489035 1.0 13.08117494452758 -7.568841723480045 5.387538493580197 0.9080413217696742 1.1017804050304347 0.511566816584434 0.0834510008598527 0.1501681496332553 10.086011947784462 0.03887569318697844 0.022278252908547992 2.6987227896906686e-08 7.568841723480045 0.1937390832607605 GVSMSLPS(ph)SPLLPR ddPTM_A459_Selumetinib_30min_R2 1 GVSMSLPSSPLLPR 14 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 GVSMS(0.002)LPS(0.593)S(0.405)PLLPR 103.11 0.027002 3773700.0 28616.0 28160.0 27072.0 33431.0 31169.0 18561.0 27413.0 30434.0 20148.0 24891.0 True False 27025.637278924234 30319.78145132868 25330.216993764945 28877.64012830831 27253.271565604555 21117.609270017776 28687.75881782901 30522.557901380093 24178.162982156115 24172.33215541526 1.1180401255933328 1.2543175915500657 1.0479012463880233 1.19465676471101 1.1274572676885495 0.8736272997674681 1.186801448589319 1.262706374591258 1.0002412190393284 1.0 14.561069051111305 -9.478092273194962 0.01555159980820972 1.1906232848576321e-06 2.12800998208781 0.11270331950703028 0.11198660633296387 3394.264285873285 16.397486528374984 1182.9486777829266 1059.8050030343013 3.3258888166350505e-10 9.478092273194962 2.128008791464525 GVSMSLPSS(ph)PLLPR ddPTM_A459_Selumetinib_30min_R1 2 GVSMSLPSSPLLPR 14 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 GVSMS(0.001)LPS(0.332)S(0.668)PLLPR;GVSMSLPS(0.003)S(0.997)PLLPR 253.97 7.1415e-28 78759000.0 8443.2 9969.099999999999 9941.7 11959.9 11241.900000000001 7971.6 9480.4 8716.3 4452.6 7934.5 True False 8639.910132392703 8801.91313749115 8591.671745849115 9871.327980127977 10225.07212991865 7891.412941633695 8765.285795286172 8485.115409467395 7555.736994962857 8952.970363574897 0.9650328082782583 0.983127697294931 0.9596448326026272 1.1025757462896797 1.1420871190995214 0.8814295838328536 0.9790366145908046 0.947743046708725 0.8439363348842664 1.0 13.128150695289259 -6.789544552408887 24.999994729889313 0.9302010311219587 1.0279308486826035 0.3490817105778564 0.0682750482698668 275.7762678044325 245305.295904285 0.025535660719545508 0.022524895276273636 1.6235117928252526e-07 6.789544552408887 0.0977298175606448 GVSMSLPSS(ph)PLLPR ddPTM_A459_Selumetinib_30min_R2 2 GVSMSLPSSPLLPR 14 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 GVSMS(0.001)LPS(0.045)S(0.955)PLLPR;GVSMSLPS(0.237)S(0.762)PLLPR 193.11 0.00011415 44683000.0 95301.0 83972.0 101390.0 103059.0 127196.0 67660.0 88950.0 89450.0 75460.0 90045.0 True False 90004.55194012992 90412.38238746344 94866.67778508538 89022.18641330877 111216.50133333246 76979.55084367235 93086.35125108124 89710.28469075536 90554.10852856352 87445.1668849932 1.029268456408835 1.0339322984696533 1.0848704527015525 1.0180343818245512 1.2718427478056393 0.8803179590807448 1.0645111052679133 1.025903293303119 1.0355530414580734 1.0 16.416091027804548 GVSPS(ph)QAQGLGSNLVTEVR ddPTM_A459_Selumetinib_30min_R1 1 GVSPSQAQGLGSNLVTEVR 19 0 U3KQS6;A0A0A0MQU7;F5H0K0;A0A0A0MTK8;P20823-3;P20823-2;P20823;P20823-7;P20823-6 U3KQS6 HNF1A Hepatocyte nuclear factor 1-alpha 1 GVS(0.392)PS(0.608)QAQGLGSNLVTEVR 229.48 1.321e-23 5746200.0 307.08 559.1 487.55 460.67 608.93 320.9 360.9 324.6 226.33 445.09 True False 314.23436652633484 493.6403120814616 421.34338792045014 380.22263234688853 553.8523890153233 317.6720373538876 333.677022437743 315.99055355060227 384.065479510835 502.22163704373935 0.625688626989537 0.9829132710952269 0.8389590508298921 0.7570813447724362 1.102804714419517 0.6325335547544739 0.6644019250183809 0.6291854636344194 0.7647330405188937 1.0 8.972180374862166 GVSS(ph)ESSGDREK ddPTM_A459_Selumetinib_30min_R1 1 GVSSESSGDREK 12 1 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 GVS(0.216)S(0.784)ESSGDREK 143.55 0.003876300000000001 13928000.0 3196.6 2957.3 3965.2 4072.2 3580.2 3108.7 3335.3 2918.1 2095.5 2503.0 True False 3271.07456049916 2611.057941188529 3426.747619284523 3361.066714661253 3256.371542135649 3077.429300473764 3083.715635734566 2840.7025086753333 3555.9104507354496 2824.284431284639 1.1581958687536638 0.9245024730037112 1.2133153379760162 1.1900595695782865 1.1529899418290788 1.0896315067933795 1.0918573220091445 1.005813181281896 1.2590482783343555 1.0 11.4636696731792 -6.805627190672762 21.836646202849085 1.0897948437923684 1.1247259277931232 0.0360862424109728 0.09894045321086342 182.91440395453932 90388.28310903512 0.03492951267987523 0.030805503694683573 1.5644900640695774e-07 6.805627190672762 0.03493108400075484 GVSS(ph)PVETR ddPTM_A459_Selumetinib_30min_R2 2 GVSSPVETR 9 0 A8MVZ6;Q96G01-4;Q96G01-3;Q96G01 A8MVZ6 BICD1 Protein bicaudal D homolog 1 1 GVS(0.144)S(0.856)PVETR;GVS(0.042)S(0.957)PVETR 104.42 0.011335 3295500.0 85550.0 77483.0 88924.0 87946.0 101748.0 71353.0 89022.0 99326.0 80247.0 86561.0 True False 80795.47348378424 83425.696952887 83202.72665313055 75967.60308468781 88965.50660133903 81181.22807195621 93161.69939374643 99615.0222156955 96298.64228851913 84061.75901751252 0.9611442162059942 0.9924333957311907 0.9897809375580279 0.903711794430349 1.058335057951915 0.9657331588200978 1.1082530330389366 1.1850218622589468 1.1455701547770052 1.0 16.359162025181504 -7.308864567940744 5.1209871445453725 1.127313436738017 0.979728317007837 0.5507182106176103 0.05729016983895862 0.14151546456048358 8.76827574079118 0.023391520068080207 0.015803826928363632 4.910609866221977e-08 7.308864567940744 -0.14758511973018007 GVSTVIDAAS(ph)GTFDR ddPTM_A459_Selumetinib_30min_R2 1 GVSTVIDAASGTFDR 15 0 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6;Q9H6U6-8;Q9H6U6-3;Q9H6U6-7 K7ESE9;Q9H6U6-8 BCAS3 Breast carcinoma-amplified sequence 3 1 GVSTVIDAAS(0.997)GT(0.003)FDR 157.68 0.00015267 3293800.0 9272.6 8267.1 9113.4 11113.0 9483.5 7686.5 6189.1 8458.4 4382.3 6657.8 True False 8757.266013158829 8901.159987083776 8527.053765919673 9599.390229005723 8292.097946434313 8745.2456039002 6476.905413468992 8483.012543636502 5258.882451692616 6465.572014958168 1.3544456689831623 1.3767010817435563 1.3188398097171055 1.4846931109571486 1.2825002841589974 1.3525865281011462 1.0017528841198589 1.3120281583765463 0.8133669286377349 1.0 12.658562296868906 -7.545552029428758 0.8975159918213842 0.9574099260849295 1.3813179639962871 0.633666706560175 0.1229814903489328 0.37166917281580464 0.5527368136829321 0.09749665794193428 0.046479825836996135 2.84739665539248e-08 7.545552029428758 0.42390803791135767 GVT(ph)LGFR ddPTM_A459_Selumetinib_30min_R1 2 GVTLGFR 7 0 D6RAN4;P32969;H0Y9V9;E7ESE0;A0A2R8Y5Y7 D6RAN4 RPL9 60S ribosomal protein L9 1 GVT(1)LGFR;GVT(1)LGFR 101.72 0.031160000000000007 0.0 2508.2 2836.1000000000004 3198.7 2881.6 2438.9 2337.0 2246.7200000000003 2854.1 1365.13 2093.6 True False 2566.636179892383 2504.04809353288 2764.3341092014 2378.3826543312875 2218.301925622769 2313.4919018262244 2077.248101555351 2778.399996576632 2316.525904849671 2362.333953390938 1.0864832113208152 1.05998903751035 1.1701707564391663 1.0067935784088922 0.9390297770721947 0.9793246625886214 0.8793202580751254 1.17612498969016 0.980608986940431 1.0 11.20599721165154 -5.888648594627426 7.921413586872884 0.9929866539764971 1.1005778506486161 0.3152382158036615 0.07514665888268336 0.30339762815240545 20.00864976033331 0.021592360034291897 0.032151496580236257 1.2922644745743662e-06 5.888648594627426 0.10759119667211903 GVTECYECHPKPTQR ddPTM_A459_Selumetinib_30min_R2 1 GVTECYECHPKPTQR 15 1 K7EPL2;Q9UBT2-2;Q9UBT2 K7EPL2 UBA2 SUMO-activating enzyme subunit 2 0 99.011 0.0067788 2848900.0 17125.0 13868.0 16931.0 18480.0 20655.0 14309.0 16071.0 19445.0 15057.0 15580.0 False True 16173.261056806605 14931.631007351774 15841.677893078991 15962.992120221868 18060.134241957152 16279.934865830746 16818.333344082366 19501.58173070695 18068.820727731032 15130.164918298566 1.0689414916585944 0.9868782718483998 1.0470261215672485 1.0550441588984978 1.193650851757409 1.0759918978901306 1.111576340039897 1.2889206321288376 1.194224968815669 1.0 13.885140092518164 -6.133513271943413 4.755926968883948 1.1532243575134247 1.032605548445958 0.3139816288559689 0.07527127891243719 0.26362204593527694 9.064135716261088 0.022898953682756337 0.03006036892551235 7.35337523379783e-07 6.133513271943413 -0.12061880906746669 GVTIPYRPKPS(ph)SSPVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 GVT(0.001)IPY(0.003)RPKPS(0.332)S(0.332)S(0.332)PVIFAGGQDR 45.659 0.029627 243690000.0 160860.0 151660.0 158770.0 140740.0 149380.0 119350.0 100740.0 133610.0 87435.0 118270.0 True False 151920.04517360043 163291.83433623947 148554.9110557054 121570.96920995797 130613.54892585608 135789.37914857082 105424.60961252292 133998.78297967394 104924.4431380199 114855.23779763604 1.32270889936486 1.4217186561743407 1.2934099820283769 1.0584712681902624 1.1372015019113424 1.182265447813697 0.9178911787921332 1.1666754215925876 0.91353642332696 1.0 16.809457124555955 -5.647672120900368 0.6544334129368637 1.0174240236661878 1.4625136221746466 0.6686164075526534 0.09382258832912084 0.8083408628849065 0.5340666405833843 0.05078349063230843 0.23250505235916444 2.2507532146462735e-06 5.647672120900368 0.44508959850845886 GVTIPYRPKPSS(ph)SPVIFAGGQDR ddPTM_A459_Selumetinib_30min_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 GVTIPYRPKPS(0.012)S(0.494)S(0.494)PVIFAGGQDR 101.17 4.8477e-05 458980000.0 2351.5 2413.5 2688.1 2986.4 2605.7 2146.6 2361.5 2276.1 1378.1 2134.2 True False 2406.285374777506 2130.9262979942896 2323.070784676364 2464.881301670932 2370.0148950737002 2125.007152956857 2183.3701537454435 2215.7304341852328 2338.5350475583496 2408.145358868428 0.9992276279818109 0.8848827543348954 0.9646721598931884 1.0235600158410552 0.9841660456025607 0.882424786000204 0.9066604495882238 0.9200982930807757 0.9710938083310768 1.0 11.233706762386513 -6.723708653030981 24.999796788547158 0.9292242704651492 0.9690356049368561 0.12059483424761686 0.04556206432310433 337.1766289699024 223407.0101858691 0.015529454433499658 0.01552908701582956 1.8892583352673745e-07 6.723708653030981 0.03981133447170693 GVTIPYRPKPSS(ph)SPVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 GVTIPY(0.001)RPKPS(0.105)S(0.447)S(0.447)PVIFAGGQDR 57.142 0.018571 11915000.0 25476.0 33847.0 40628.0 22683.0 28880.0 30424.0 27328.0 18791.0 16385.0 28898.0 True False 24060.14590850832 36442.95606474151 38014.03871242176 19593.536269642464 25251.836209524216 34614.62983842579 28598.806149404692 18845.678698982498 19662.457835151286 28063.63965397896 0.8573423192845546 1.2985826683237969 1.3545655225455404 0.6981822925047579 0.899806173428539 1.233433377324527 1.0190697465483547 0.6715336617540445 0.7006381951018059 1.0 14.77641450790243 -7.676939093123158 6.2715610853990595 0.7660172122131453 1.0628049538569277 0.24299861760783337 0.20982551483122477 0.27984404751230585 16.534478020835223 0.10518066490214169 0.05960137080201798 2.1040735012169403e-08 7.676939093123158 0.2967877416437824 GVTIPYRPKPSS(ph)SPVIFAGGQLTK ddPTM_A459_Selumetinib_30min_R2 1 GVTIPYRPKPSSSPVIFAGGQLTK 24 2 H3BRU6;F8VZX2 H3BRU6 PCBP2 1 GVT(0.029)IPY(0.025)RPKPS(0.024)S(0.46)S(0.46)PVIFAGGQLT(0.001)K 43.162 0.033506 3379800.0 15512.0 14231.0 16901.0 17492.0 16521.0 11802.0 14943.0 11507.0 11535.0 11632.0 True False 14649.905139456 15322.471940122818 15813.608060417448 15109.559424616933 14445.484280386065 13427.618372110865 15637.879108992767 11540.483464913601 13842.322314828805 11296.153936434466 1.2968931923107376 1.3564326430345393 1.3999108147253947 1.3375844123266378 1.2787966914822035 1.1886893935467364 1.3843542852717825 1.0216294439553517 1.2254013527721113 1.0 13.463544033488727 -7.982941528900451 0.4509313215684421 0.9977478544164251 1.3660302673964497 0.594766776343697 0.08577491204882033 0.6318130124600274 0.3387178959554594 0.09285163331776596 0.06326474959795156 1.0400601845755698e-08 7.982941528900451 0.3682824129800246 GVTIPYRPKPSSS(ph)PVIFAGGQDR ddPTM_A459_Selumetinib_30min_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 GVT(0.004)IPY(0.02)RPKPS(0.017)S(0.068)S(0.891)PVIFAGGQDR 65.887 0.0016377 605630000.0 3951.0 4431.5 4292.7 4334.0 4107.1 3560.8 3767.8 3577.4 2043.7 3471.2 True False 4043.0506126922915 3912.6579198515424 3709.77491811325 3577.148259255901 3735.6135301673994 3524.9815849477204 3483.5918125268186 3482.5157309671135 3468.0096340577584 3916.762332351276 1.0322430287122382 0.9989520904891694 0.9471534403483274 0.9132921417543604 0.9537503716557826 0.8999733161832248 0.8894059728243913 0.8891312353069226 0.8854276414509618 1.0 11.93544587342025 -4.9711418785255805 0.8878196341383854 0.9088783532363647 1.0843482924705308 0.5616263683124216 0.03392671337098727 1.1814790603980811 0.886119570937855 0.011962178249391456 0.19048132761454356 1.068705689528246e-05 4.9711418785255805 0.1754699392341661 GVTIPYRPKPSSS(ph)PVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 2 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 GVTIPYRPKPS(0.047)S(0.134)S(0.819)PVIFAGGQDR;GVTIPY(0.003)RPKPS(0.304)S(0.304)S(0.389)PVIFAGGQDR 54.658 0.014342 201070000.0 279992.0 282207.0 249018.0 234710.0 245163.0 212105.0 221351.0 217601.0 162412.0 239683.0 True False 264431.16553678206 303851.36946147477 232996.4529902988 202742.09310266643 214363.43215497155 241320.53845251468 231644.26009868554 218234.1828842154 194898.93817043622 232762.72901877813 1.1360545850768449 1.3054124719295654 1.0010041297097088 0.8710247295919538 0.9209525642641773 1.0367662360284757 0.99519481093555 0.937582162763736 0.8373288068585617 1.0 17.82850054056727 -5.387261423083598 5.088863443448272 0.944822029179848 1.2181309079129692 0.719354448928602 0.06830283047163929 0.10943996143658082 4.024186205009882 0.018278640950248184 0.039262594953603895 4.09957255382259e-06 5.387261423083598 0.27330887873312115 GVTIPYRPKPSSS(ph)PVIFAGGQLTK ddPTM_A459_Selumetinib_30min_R1 1 GVTIPYRPKPSSSPVIFAGGQLTK 24 2 H3BRU6;F8VZX2 H3BRU6 PCBP2 1 GVT(0.087)IPY(0.068)RPKPS(0.267)S(0.267)S(0.312)PVIFAGGQLTK 49.445 0.017667 35594000.0 2912.3 3240.1 3688.2 4020.6 3081.1 3503.2 3131.6 3048.7 1948.5 2807.0 True False 2980.150923650661 2860.747585718375 3187.362697832434 3318.4776860092934 2802.415049012388 3467.960988651102 2895.3808907343764 2967.8385724267473 3306.4621871906556 3167.3057924954 0.9409103884796399 0.9032116799383935 1.0063324815003833 1.0477288596106127 0.8847945959788339 1.0949245875999953 0.9141463061743765 0.9370230621428252 1.0439352572223914 1.0 11.629040446003394 -5.261735470241673 24.99997858791817 0.9880454599759745 0.9220610314950012 0.1657341705270775 0.06166194969502938 45.804125300760134 3867769.740148655 0.015357041075086739 0.035567536322462144 5.473492530567639e-06 5.261735470241673 -0.0659844284809733 GVVDSDDLPLNVSR ddPTM_A459_Selumetinib_30min_R1 2 GVVDSDDLPLNVSR 14 0 P14625 P14625 HSP90B1 Endoplasmin 0 ; 196.27 0.0016444000000000005 8601600.0 4647.299999999999 5614.8 5035.200000000001 5780.9 4820.200000000001 4661.799999999999 5078.9 4712.3 3214.5 4126.6 False True 4755.573047928342 4957.416605750297 4351.44749637381 4771.374335932728 4384.213761075433 4614.906524575736 4695.7944839541515 4587.314496292373 5454.771722209069 4656.289306487894 1.021322502728108 1.064671088809457 0.934531170627794 1.0247160392900156 0.9415681613611591 0.9911124977018725 1.0084842617943033 0.9851867429930925 1.1714847087805735 1.0 12.184964983816503 -8.219596793058589 24.997342427614505 1.0857425372217997 0.995995339392678 0.3135704173503294 0.05284223174659278 469.5187140649774 280497.89634870016 0.03352736032743247 0.012671857664566468 6.031192731881771e-09 8.219596793058589 -0.08974719782912166 GVVDSDDLPLNVSR ddPTM_A459_Selumetinib_30min_R2 2 GVVDSDDLPLNVSR 14 0 P14625 P14625 HSP90B1 Endoplasmin 0 ; 148.13 0.0064451000000000005 31692000.0 133515.0 116472.0 136480.0 151629.0 154892.0 125111.0 120701.0 135930.0 112191.0 126450.0 False True 126094.7708028923 125405.02788349293 127699.02538818867 130976.86862538538 135433.082207951 142343.9046054197 126313.8356644942 136325.53379557724 134632.3348784532 122799.05994344373 1.0268382417663982 1.0212213997505306 1.039902304195176 1.066595043037854 1.1028837050570743 1.159161191225548 1.0286221712337964 1.110151281763584 1.0963629114136493 1.0 16.905939991007095 -5.811814260431324 2.5059613998135832 1.089171670435399 1.0255042293767378 0.24287891381054783 0.041618226795143744 0.3501014013796021 4.479085421366908 0.01204024680455899 0.021107948508348337 1.5423599502079777e-06 5.811814260431324 -0.06366744105866129 GVVDSEDLPLNISR ddPTM_A459_Selumetinib_30min_R1 4 GVVDSEDLPLNISR 14 0 P07900;P07900-2;P08238 P07900;P08238 HSP90AA1;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta 0 ;;; 312.95 5.238199999999998e-93 97561600.0 6055.58 6839.71 7657.2 8242.6 7185.5 6358.17 6879.82 6320.18 4691.74 5745.39 False True 6196.663231892481 6038.9135735050895 6617.394297988863 6803.18464276481 6535.572793703062 6294.212582556458 6360.869638425138 6152.548295562064 7961.5401088683 6482.866771337774 0.9558523181888199 0.9315190002368239 1.0207512403688237 1.0494099111897894 1.008130048668949 0.9708995733777226 0.9811816072710282 0.9490474681299756 1.2280894224246712 1.0 12.662416209222602 -8.237130803192636 24.985761527829293 1.1140447779864593 0.9854088256185892 0.4232085757762001 0.060993541687542306 611.9735304484858 629023.8497308202 0.03962995390073398 0.014963805385237606 5.792542071940948e-09 8.237130803192636 -0.12863595236787007 GVVDSEDLPLNISR ddPTM_A459_Selumetinib_30min_R2 4 GVVDSEDLPLNISR 14 0 P07900;P07900-2;P08238 P07900;P08238 HSP90AA1;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta 0 ;;; 247.29 3.6766e-26 80504000.0 145457.0 144458.0 140646.0 175429.0 184118.0 132425.0 133216.0 133678.0 119524.0 157791.0 False True 137373.08225050627 155537.46409431915 131596.9894837861 151535.26756809533 160987.45080419607 150665.34171553826 139410.8079624963 134066.9808484157 143432.13977959217 153235.16383974656 0.896485368033222 1.0150246209608933 0.8587910645719042 0.9889066175866201 1.050590783278418 0.9832295534535676 0.909783397421053 0.8749100238416754 0.9360262761202357 1.0 17.22538787402363 -10.071616879297547 12.29008604352984 0.9999999999446492 0.9477199757086306 0.06826790148661532 0.05956520782816167 0.0 0.0 0.060391427041288234 0.014647072504294947 8.479751408313607e-11 10.071616879297547 -0.05228002423601852 GVVIPTWNIS(ph)PIKK ddPTM_A459_Selumetinib_30min_R2 1 GVVIPTWNISPIKK 14 1 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2;A4PB68 Q3T8J9-3 GON4L GON-4-like protein 1 GVVIPT(0.03)WNIS(0.97)PIKK 70.783 0.029071 3899300.0 20936.0 22488.0 21525.0 21458.0 21016.0 17019.0 18708.0 18671.0 14820.0 19104.0 True False 19772.460933448358 24212.757289683203 20140.104934647992 18535.383382885328 18375.782194576208 19363.212766900084 19577.95906919874 18725.329518849554 17784.414105397736 18552.417881846988 1.0657619432341026 1.305099822776992 1.0855784438940712 0.999081817848749 0.9904791015168102 1.0437029227250447 1.055278034048339 1.0093201672204546 0.9586035749442275 1.0 14.179319600833939 -5.505059822737485 6.1145186540652725 1.0129983790377506 1.188886024205527 0.5861524659447238 0.05940944232727305 0.10148618575673661 14.39465817235957 0.0150041784836717 0.02947814415266207 3.1256487889019183e-06 5.505059822737485 0.17588764516777644 GVVPLAGTDGETTTQGLDGLSER ddPTM_A459_Selumetinib_30min_R1 2 GVVPLAGTDGETTTQGLDGLSER 23 0 P09972;K7EKH5;C9J8F3;J3KSV6;J3QKP5;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 ; 178.47 1.695e-15 14842900.0 4198.5 4582.2 4263.4 4467.0 4822.4 4403.9 4457.700000000001 3905.0 2622.7 3654.6 False True 4296.316881141127 4045.7138937930117 3684.4536971798693 3686.922305975106 4386.214771463872 4359.600764421273 4121.452100085142 3801.426714772342 4450.530345570919 4123.703508818552 1.0418588222827951 0.9810874824393269 0.8934817183875258 0.8940803571572524 1.063659102087223 1.0572051931227 0.9994540323452946 0.9218477290239174 1.0792556584277815 1.0 12.009724892408338 -6.266602133207922 24.986717458001085 1.017138603445326 0.9504353104287265 0.24800322963871146 0.05747369321368722 691.1180196300216 3344869.609602498 0.018808321955282623 0.021975891143038866 5.412499469469286e-07 6.266602133207922 -0.0667032930165995 GVVPLAGTDGETTTQGLDGLSER ddPTM_A459_Selumetinib_30min_R2 1 GVVPLAGTDGETTTQGLDGLSER 23 0 P09972;K7EKH5;C9J8F3;J3KSV6;J3QKP5;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 137.73 5.9397e-05 4063300.0 16964.0 14812.0 20224.0 20305.0 22944.0 17356.0 10363.0 17492.0 16727.0 18578.0 False True 16021.208792272537 15948.032771913362 18922.809858226283 17539.42397192128 20061.569598037502 19746.631457918673 10844.900033894932 17542.89882404351 20072.867391429703 18041.60486855912 0.8880146144976547 0.883958654903578 1.0488429380915458 0.9721653976851591 1.1119614770523298 1.0945052616871618 0.6011050631529019 0.9723579998481898 1.1125876848356455 1.0 14.139040056996931 -5.2288450755549905 21.951159804933603 0.9818811633739238 0.8859863489443751 0.07789183951912726 0.14024450101198893 465.9266316445063 313777.10769040586 0.037499948303094915 0.09917708015195549 5.904116582230849e-06 5.2288450755549905 -0.09589481442954872 GVVPLAGTNGETTTQGLDGLS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 GVVPLAGT(0.029)NGET(0.121)T(0.101)T(0.101)QGLDGLS(0.648)ER 63.45399999999999 0.043938 0.0 4688.7 3653.1 4812.1 4826.1 5542.9 4811.5 3636.1 4740.3 4049.2 3342.7 True False 4428.12082435323 3933.281023432128 4502.494725018331 4168.776854513137 4846.551347845282 5474.240450551724 3805.185854795461 4754.093488201088 4859.153144100978 3246.187565622377 1.3640988805599858 1.211661662772101 1.3870100337702107 1.2842070183069891 1.4929979398513513 1.6863598728935962 1.172201475691966 1.4645159566710395 1.4968799694633033 1.0 11.664530646277923 -10.74667329742819 3.989509484650406 0.9997073626944327 1.3934927172836247 0.4056177224323132 0.1436270928553708 35212501.024755985 57.35381253153664 101874.45655992394 0.0355254617176484 1.7919533628149157e-11 10.74667329742819 0.39378535458919195 GVVPLAGTNGETTTQGLDGLSER ddPTM_A459_Selumetinib_30min_R1 2 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 231.21 6.0723e-30 13213100.0 4607.6 4940.9 5083.299999999999 5185.2 5354.2 4862.4 5099.5 5149.5 3567.2999999999997 4664.0 False True 4714.948115171099 4362.417131037909 4393.015780568196 4279.702158258812 4869.913555360786 4813.488670705961 4714.840609368995 5012.918532066625 6053.447554716564 5262.669831207176 0.895923222698081 0.8289361238603937 0.8347504064416112 0.8132188215343759 0.9253693869379037 0.9146476646059745 0.8959027947013507 0.9525428523637285 1.1502617015455054 1.0 12.361579170691366 -7.987378883943425 2.9621152801206168 1.074305130715968 0.8704851813884464 0.719643044926207 0.04985239678332827 0.13770549803309967 2.3764853927540406 0.03741652306499683 0.013814719626713408 1.0294875906908924e-08 7.987378883943425 -0.20381994932752145 GVVPLAGTNGETTTQGLDGLSER ddPTM_A459_Selumetinib_30min_R2 3 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;; 281.49 9.364699999999995e-78 14247900.0 59291.0 42238.0 55757.0 56964.0 59610.0 43913.0 49730.0 49466.0 41330.0 48579.0 False True 55995.84358067851 45477.51878342402 52169.655323631516 49205.40493161894 52121.2588798386 49961.61714747537 52042.54353812557 49609.93787046285 49597.15485668613 47176.39804659987 1.1869461404274013 0.9639887881754404 1.1058422746073029 1.0430089402547194 1.1048164132487246 1.059038400899626 1.103147880995896 1.0515838411711547 1.051312879115847 1.0 15.525777651482443 -8.638794734487709 1.3718758411539258 1.0005490920494904 1.075588330074756 0.1649541007226104 0.0539499627772371 1.051639775593382 4.147897072553795 0.04702147649299646 0.014050801584770537 2.297234159322905e-09 8.638794734487709 0.07503923802526558 GVVVLAK ddPTM_A459_Selumetinib_30min_R2 1 GVVVLAK 7 0 P52895;B4DK69;H0Y804;P17516;Q04828;A0A0A0MSS8;P42330;S4R3Z2;P42330-2 P52895;Q04828;A0A0A0MSS8;P42330-2 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 140.79 0.043127 17675000.0 201090.0 188600.0 199170.0 166070.0 201350.0 144490.0 168570.0 134040.0 139220.0 186700.0 False True 189914.2228270507 203065.01355541832 186355.61903989993 143450.9795132711 176054.61290816133 164392.18595037286 176408.83901511796 134430.03420848335 167067.89013181374 181309.4858951441 1.047458834762142 1.1199911165864536 1.0278316003150223 0.7911940117475842 0.9710171094411364 0.9066937956320997 0.9729708191723608 0.7414396083293053 0.9214514580248346 1.0 17.46809488157006 -5.578343465610467 7.050131589876006 0.8964098093162327 1.0815370581236454 0.49165589359992445 0.07788483868045051 0.15540982487507932 15.895447085609714 0.020537306891997852 0.0359281002553309 2.6403198112568076e-06 5.578343465610467 0.18512724880741271 GVVVVIK ddPTM_A459_Selumetinib_30min_R2 2 GVVVVIK 7 0 P46779;H0YMF4;H0YKD8;P46779-4;P46779-5;P46779-2;P46779-3 P46779 RPL28 60S ribosomal protein L28 0 ; 140.79 0.043127 4410700.0 53387.0 44125.0 54384.0 55898.0 54215.0 42631.0 44502.0 43952.0 36567.0 44937.0 False True 50419.964265093964 47509.24561576271 50884.9926488221 48284.595970571565 47404.02701175049 48503.033284312696 46571.4311790401 44079.89304335469 43881.421767346794 43639.55204965232 1.1553730938330213 1.0886739983423186 1.1660292156740302 1.1064411457668997 1.0862629148396166 1.1114466351333487 1.0671839877286535 1.010090410488205 1.0055424427230435 1.0 15.413348672341538 -7.5155786293548825 1.0226112414003847 0.9927777702827599 1.1253150617018919 0.8247607513845201 0.02363577689190196 0.21244540932321185 0.4113169456239673 0.01871826316495962 0.008777362968563228 3.050853619706664e-08 7.5155786293548825 0.13253729141913195 GWAFGSNS(ph)LPIAGSVGMGVAR ddPTM_A459_Selumetinib_30min_R1 3 GWAFGSNSLPIAGSVGMGVAR 21 0 M0QZ22;Q5PRF9;A0A087WZT0 M0QZ22 SAMD4B Protein Smaug homolog 2 1 GWAFGSNS(0.985)LPIAGS(0.015)VGMGVAR;GWAFGSNS(0.994)LPIAGS(0.006)VGMGVAR;GWAFGS(0.001)NS(0.999)LPIAGSVGMGVAR 181.23 4.5484e-13 30392000.0 5124.4 5304.4 6082.700000000001 5818.6 5209.5 4891.9400000000005 4900.8 4823.9 2705.09 4123.74 True False 5243.788549653348 4683.358382051342 5256.702749879442 4802.490738649372 4738.301644811929 4842.731525126135 4531.128710343286 4695.9545017644805 4590.340158043405 4653.062197629133 1.1269543210329762 1.0065110207290258 1.1297297406765552 1.0321140218362819 1.0183190001685831 1.0407622592265464 0.9737950016339829 1.009218080978415 0.9865202662415115 1.0 12.183964756436245 -6.339268856650884 0.9197205515683976 0.9940025025524692 1.0833239790946017 0.4986328635207724 0.03643568148781113 0.5009805884250034 0.9124906960558365 0.017514026638711284 0.025751355149552218 4.578583547339054e-07 6.339268856650884 0.0893214765421324 GWAFGSNS(ph)LPIAGSVGMGVAR ddPTM_A459_Selumetinib_30min_R2 4 GWAFGSNSLPIAGSVGMGVAR 21 0 M0QZ22;Q5PRF9;A0A087WZT0 M0QZ22 SAMD4B Protein Smaug homolog 2 1 GWAFGS(0.021)NS(0.672)LPIAGS(0.307)VGMGVAR;GWAFGS(0.003)NS(0.949)LPIAGS(0.049)VGMGVAR;GWAFGS(0.005)NS(0.924)LPIAGS(0.071)VGMGVAR;GWAFGS(0.456)NS(0.544)LPIAGSVGMGVAR 182.39 1.6477e-14 32077200.0 92222.0 77740.0 88943.8 85920.0 90630.0 66254.6 70097.0 73026.0 62806.0 79487.0 True False 87096.67043391638 83702.40802650189 83221.25274268715 74217.54777973291 79244.24915752005 75380.56975062334 73356.6493945705 73238.49356989493 75368.95494626265 77192.00377797184 1.1283120811895677 1.0843403970605037 1.0781071700387168 0.9614667860314341 1.0265862431224237 0.9765333980374606 0.9503140973716266 0.9487834229637511 0.9763829316187613 1.0 16.236163787828417 -5.441470076933099 0.9182738609452582 0.9681469292875761 1.1456910924666985 0.8080733133660801 0.02641617400243408 0.38727717227674907 0.4878459214585212 0.010091462989503516 0.05638717075394634 3.6185112156338037e-06 5.441470076933099 0.17754416317912247 GWDAEGS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 2 GWDAEGSPFR 10 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 1 GWDAEGS(1)PFR;GWDAEGS(1)PFR 87.667 0.033331 3176200.0 34664.0 29765.0 33161.0 41685.0 41445.0 32029.0 31580.4 36532.0 33225.0 31081.0 True False 32737.513650986522 32047.879790440267 31027.45736296686 36007.43108936411 36238.308576998985 36440.70401968641 33048.951175375456 36638.30207180185 39870.92838406478 30183.61077186379 1.0846122386889312 1.0617642810420247 1.027957112138806 1.192946442409372 1.2005955434191853 1.2073010182617145 1.094930339023012 1.2138475528565629 1.320946280596462 1.0 14.881477780876818 -5.767395891043876 24.997174740894266 1.1836823468004796 1.0584765106048992 0.3094737480429628 0.07995154831217857 154.50308361309735 648392.443702391 0.021728756922897073 0.033210289416439144 1.7084572218795757e-06 5.767395891043876 -0.12520583619558034 GWDLVDAVT(ph)PGPQPTLEQLEEGGPRPLER ddPTM_A459_Selumetinib_30min_R1 1 GWDLVDAVTPGPQPTLEQLEEGGPRPLER 29 1 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 GWDLVDAVT(0.875)PGPQPT(0.125)LEQLEEGGPRPLER 66.77 0.00077815 4546600.0 312.9 554.03 541.2 488.99 518.58 615.65 792.44 424.09 237.12 475.47 True False 320.18996120258635 489.1639100384405 467.7080125988052 403.5970759791283 471.6745305627354 609.457119965475 732.6656128028956 412.84175556153735 402.37532144041535 536.5012059699992 0.5968112608874381 0.9117666551262035 0.8717743919199301 0.7522761766199966 0.8791676986260328 1.1359846225575037 1.3656364694991305 0.7695076002953537 0.7499989132604409 1.0 9.067437603710822 -6.551632236890809 7.838641233572596 1.0123846650822304 0.800622624343376 0.2463822842415636 0.18148331385238678 0.3340196769043413 74.15699875303 0.06436307997608129 0.0648889026013074 2.807810301720842e-07 6.551632236890809 -0.2117620407388543 GWDS(ph)SHEDDLPVYLAR ddPTM_A459_Selumetinib_30min_R2 1 GWDSSHEDDLPVYLAR 16 0 Q14195-2 Q14195-2 DPYSL3 Dihydropyrimidinase-related protein 3 1 GWDS(0.5)S(0.5)HEDDLPVYLAR 84.375 0.011339 2078700.0 11232.0 6867.1 9097.4 10634.0 13732.0 9715.1 11161.0 11451.0 9095.0 9738.1 True False 10607.770405258496 7393.784488793296 8512.08318850019 9185.630855326812 12006.863394362403 11053.266840102882 11680.00861510194 11484.320514184903 10914.25413553256 9456.935750377626 1.1216921300152551 0.7818372339579502 0.9000889308315637 0.9713115429551289 1.2696357161867105 1.168800035430241 1.2350732756787044 1.2143807272589666 1.1541004849373901 1.0 13.207157079868384 -6.1426044658833145 5.029554864655664 1.1865448310934001 0.9221076538797458 0.5409604613450401 0.10333876617846831 0.1536082767047438 5.708777445468059 0.02934250412238066 0.038372363518149454 7.201045153220083e-07 6.1426044658833145 -0.26443717721365434 GWEEGVAQMSVGQR ddPTM_A459_Selumetinib_30min_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q1JUQ5;Q5W0X3 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 215.83 1.2419e-05 10063000.0 1370.1 1563.4 1806.0 1976.7 1839.5 1438.7 1423.9 1407.5 766.65 1227.3 False True 1402.0206642494838 1380.3564011950582 1560.7551196478973 1631.5064522545308 1673.117549790103 1424.227984235083 1316.4940766115337 1370.1685277956647 1300.949056099418 1384.8359099143572 1.0124092350668386 0.9967653144410618 1.1270325303338065 1.178122577970576 1.208170251660772 1.0284453010199324 0.9506498691913253 0.9894085775695984 0.9394246977462282 1.0 10.435499325212708 -6.994626497729256 24.837943913430347 0.9719252159458974 1.1053017997708816 0.5070463905917184 0.06274471412361186 126.44494842438172 584461.9626629022 0.02518037923836043 0.022135567059328783 1.0124498077991861e-07 6.994626497729256 0.13337658382498419 GWHGY(ph)DNELMDMRGIFLAFGPDFK ddPTM_A459_Selumetinib_30min_R2 1 GWHGYDNELMDMRGIFLAFGPDFK 24 1 Q6UWR7 Q6UWR7 ENPP6 Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 1 GWHGY(1)DNELMDMRGIFLAFGPDFK 45.88 0.047714 0.0 9354.2 6862.2 4724.1 7124.2 7734.1 4522.2 6382.7 6434.5 5583.8 5897.1 True False 8834.331011829508 7388.508674549273 4420.156549211175 6153.871670069514 6762.473214268737 5145.092001555646 6679.508197080112 6453.223329711183 6700.71602440755 5726.8354004941275 1.5426200325344182 1.2901555846902413 0.7718323018031549 1.0745675822180154 1.1808394586799635 0.8984179990770667 1.1663523970854452 1.1268393237134737 1.1700556338373884 1.0 12.483522423081714 -4.997360675080752 5.381885099803924 1.0552884043859705 1.4962316357929237 0.6083034011073165 0.12559298327130228 0.10175986124586017 10.104349208436982 0.03197166890579923 0.11536857211917906 1.0060957742870173e-05 4.997360675080752 0.44094323140695324 GWLRDPS(ph)ASPGDAGEQAIR ddPTM_A459_Selumetinib_30min_R1 1 GWLRDPSASPGDAGEQAIR 19 1 P18206;P18206-2 P18206 VCL Vinculin 1 GWLRDPS(0.669)AS(0.331)PGDAGEQAIR 103.75 0.011589 0.0 849.5 1067.7 840.39 908.21 914.33 844.58 697.75 708.74 586.04 447.63 True False 869.2916971607443 942.6931876397366 726.269653931837 749.6081727131519 831.6290129380725 836.0842920172842 645.1181557382521 689.941912888028 994.4670773319029 505.08767078543497 1.7210709099451091 1.8663951669495409 1.4379081017805357 1.4841149686894477 1.6465042824047762 1.655325085874961 1.2772399586294854 1.3659844672413723 1.9688999254039603 1.0 8.98039001571766 -11.61584218510402 2.47728822702387 0.00014045649465220219 1.5883470779303557 0.43197537008857245 0.20672304009456982 4466133.673555203 939805.6794056179 25395904.894782797 0.05249464862031536 2.4219089655264006e-12 11.61584218510402 1.5882066214357036 GWLRDPS(ph)ASPGDAGEQAIR ddPTM_A459_Selumetinib_30min_R2 3 GWLRDPSASPGDAGEQAIR 19 1 P18206;P18206-2 P18206 VCL Vinculin 1 GWLRDPS(0.918)AS(0.082)PGDAGEQAIR;GWLRDPS(0.855)AS(0.145)PGDAGEQAIR;GWLRDPS(0.5)AS(0.5)PGDAGEQAIR 92.236 0.0056461 20626300.0 65086.2 72468.0 77360.0 75071.0 79905.0 83864.0 55275.5 55468.9 51114.9 80601.0 True False 61468.96956470224 78026.0625786535 72382.74182319954 64846.20029530181 69866.6195402366 95415.50475840573 57845.920276325334 55630.30531562924 61339.308269635294 78273.8397034522 0.7853066848078899 0.9968344835804984 0.9247373336663738 0.8284530379623349 0.8925922096697039 1.2189960926906913 0.7390198372212228 0.7107138927436021 0.7836501761255743 1.0 16.256242597202984 GWLRDPSAS(ph)PGDAGEQAIR ddPTM_A459_Selumetinib_30min_R1 1 GWLRDPSASPGDAGEQAIR 19 1 P18206;P18206-2 P18206 VCL Vinculin 1 GWLRDPS(0.243)AS(0.757)PGDAGEQAIR 122.97 0.0019773 14237000.0 1394.2 1285.6 2148.1 2318.4 1756.3 1284.5 1474.5 1375.7 912.27 1345.1 True False 1426.6821473590467 1135.0813543407742 1856.3998186686872 1913.5349617579316 1597.4429750999495 1271.5790962326855 1363.2772778732394 1339.2119670966226 1548.0555604354222 1517.7566873835272 0.9399939787572377 0.7478677997443385 1.2231208296429579 1.260765297668818 1.0525026760737217 0.8378016758567349 0.8982185940642462 0.8823627517038326 1.0199629316765704 1.0 10.567724814519373 -6.736736502591569 24.10488343704136 0.9184762137891461 1.0502504141433735 0.1426122006189623 0.14246618061761915 314.4566541577398 306842.9260761789 0.05195962223616908 0.05193253594202134 1.833426471034055e-07 6.736736502591569 0.13177420035422738 GWS(ph)QEGPVK ddPTM_A459_Selumetinib_30min_R2 2 GWSQEGPVK 9 0 Q9C0C2;E9PKK0 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 GWS(1)QEGPVK;GWS(1)QEGPVK 120.03 0.0067078 28199000.0 126126.0 118957.0 118023.0 136205.0 134688.0 52256.0 86077.0 102107.0 81330.0 92738.0 True False 119116.42184238188 128080.61939295848 110429.52867372644 117653.64403326924 117767.28931400261 59453.789667261946 90079.7510583398 102404.11446527617 97598.27255006721 90060.41297773876 1.3226279771982083 1.422163358551527 1.2261716887865322 1.3063857930825946 1.3076476713815701 0.6601545307365824 1.000214723427993 1.1370602363392288 1.083697812647069 1.0 16.458605472814035 -6.581945410945318 24.983527983081384 0.9860243101866666 1.318401205318967 0.6467351178527375 0.12584707738880577 51.41391288012754 21746.15066764765 0.04337847267701883 0.04337847425468899 2.618512123886413e-07 6.581945410945318 0.3323768951323005 GWSGPKPGFPEPTNNT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 GWSGPKPGFPEPTNNTPK 18 1 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3;E5RJ67;E5RJN7 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 GWSGPKPGFPEPT(0.001)NNT(0.999)PK 114.87 0.0014885 3646900.0 25803.0 27991.0 24400.0 33393.0 23884.0 23101.0 25235.0 25216.0 18811.0 24143.0 True False 24368.97255759304 30137.81969474932 22830.1305647113 28844.815793861944 20883.478394330894 26282.953060001117 26408.47750220388 25289.374385266463 22573.725623254868 23445.92885895266 1.0393690394692092 1.285418030398971 0.9737353850237321 1.230269697028777 0.890708084971293 1.1210028494974795 1.12635663364303 1.0786253996335018 0.9627993737870297 1.0 14.51704981508759 -4.773544336847782 0.15267833603995928 0.969594849586014 1.287849845078293 0.10447179556256536 0.11063444576868513 55.40412245701056 1.4583718344451735 0.49954550329990866 3.5775742971765485 1.6844404545399302e-05 4.773544336847782 0.31825499549227887 GWSQEGPVKS(ph)PAECR ddPTM_A459_Selumetinib_30min_R1 3 GWSQEGPVKSPAECR 15 1 Q9C0C2;E9PKK0 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 GWSQEGPVKS(1)PAECR;GWSQEGPVKS(1)PAECR;GWSQEGPVKS(1)PAECR 187.56 0.00011331 31803000.0 4221.75 5178.4 3796.33 3821.4399999999996 4131.71 4541.639999999999 4704.6 4987.73 3255.14 4564.23 True False 4320.108560904501 4572.110520627153 3280.809237748007 3154.0972413130744 3757.997560012649 4495.955225079187 4349.728234304813 4855.439197969647 5523.734833980904 5150.09337986508 0.838840821371219 0.8877723535076817 0.6370387866314681 0.6124349615959204 0.7296950332405622 0.8729851856000657 0.8445921099820456 0.9427866331419503 1.072550423178077 1.0 12.330382875685501 -7.579499552895078 1.1910002543566884 1.0340482354525897 0.7432838576728791 0.6324306409554529 0.08544692380296734 0.3525714039676266 0.9281847224581601 0.07548724177705463 0.03337125583183042 2.6333006546495785e-08 7.579499552895078 -0.29076437777971065 GWSQEGPVKS(ph)PAECR ddPTM_A459_Selumetinib_30min_R2 2 GWSQEGPVKSPAECR 15 1 Q9C0C2;E9PKK0 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 GWSQEGPVKS(1)PAECR;GWS(0.001)QEGPVKS(0.999)PAECR 220.72 9.4061e-09 53349000.0 66694.0 54124.0 59367.0 60700.0 58484.0 45934.0 63255.0 65284.0 49645.0 60319.0 True False 62987.41447723553 58275.1367639103 55547.39185390229 52432.555286659495 51136.717066406294 52260.99155266401 66196.48283740463 65473.96563165203 59575.38719719778 58577.433742416644 1.0752846352779972 0.9948393611806956 0.9482728809555161 0.8950981962989688 0.872976397212457 0.8921693596628352 1.1300679904908661 1.1177335954927898 1.0170364830110081 1.0 15.838057370168798 -7.26061190657029 24.999994687392427 1.0760206514601176 0.9430504231814993 0.43618940494614056 0.06626710124090275 71.33230860904317 2155176.434139473 0.028594268587334364 0.020812777511213163 5.4876713414514545e-08 7.26061190657029 -0.13297022827861826 GWY(ph)IQY(ph)IDRDPETIRRQLELEK ddPTM_A459_Selumetinib_30min_R2 1 GWYIQYIDRDPETIRRQLELEK 22 3 O60870-2;O60870 O60870-2 KIN DNA/RNA-binding protein KIN17 2 GWY(1)IQY(0.992)IDRDPET(0.008)IRRQLELEK 67.928 0.007933299999999999 0.0 7240.3 6770.6 7594.3 7084.0 6366.1 4223.2 4216.7 4390.6 3908.7 7205.6 True False 6837.913111217332 7289.883249089701 7105.691006048656 6119.146979418383 5566.333604343905 4804.907465607406 4412.784905232535 4403.375919097042 4690.5492182029775 6997.555605602838 0.9771859627299448 1.0417756799606994 1.0154533106331067 0.8744692181536755 0.7954682917970705 0.6866551316519999 0.6306180549246774 0.6292734445112983 0.6703125323430549 1.0 12.772635330784496 -6.160551865868182 1.603471005665884 0.6958833329090371 1.018845785551065 0.5844181832643786 0.1037521647145694 0.23341761961204216 1.1947556667552244 0.035109025841428686 0.051683465443588615 6.909524070889475e-07 6.160551865868182 0.32296245264202794 GYADS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 4 GYADSPSK 8 0 Q01518-2;Q01518;Q5T0R7;Q5T0R6;Q5T0R5;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R1;Q5T0R9;Q5T0R8;Q5T0S3 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 1 GYADS(0.999)PS(0.001)K;GYADS(0.994)PS(0.006)K;GYADS(0.998)PS(0.002)K;GYADS(0.998)PS(0.002)K 148.91 0.0014999 480807000.0 34301.8 47720.8 43692.5 38109.1 37082.600000000006 41047.3 38442.3 41432.5 35785.1 39551.2 True False 35100.965200315986 42133.62655120198 37759.29848572302 31454.061081404936 33728.48537746479 40634.40142996646 35542.56636092672 40333.57550827274 60724.7010597056 44627.98178131243 0.7865236965525114 0.9441078191182076 0.8460902101903786 0.7048058152290463 0.7557699011069394 0.9105139826641624 0.7964188596986892 0.9037732359468262 1.3606866955640267 1.0 15.44566094437519 -8.092438123251458 5.84981196151554 1.1758479356714095 0.8244845232886059 0.648243404054655 0.10437558145999057 0.13489131336203325 6.7910091693865935 0.06981337232950292 0.02580502384025806 8.082800818090033e-09 8.092438123251458 -0.35136341238280366 GYADS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 4 GYADSPSK 8 0 Q01518-2;Q01518;Q5T0R7;Q5T0R6;Q5T0R5;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R1;Q5T0R9;Q5T0R8;Q5T0S3 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 1 GYADS(0.974)PS(0.026)K;GYADS(0.99)PS(0.01)K;GYADS(0.951)PS(0.049)K;GYADS(0.908)PS(0.092)K 112.36 0.011207 359398000.0 378121.0 295299.0 267141.0 341840.0 302412.0 288703.0 521344.0 700473.0 346790.0 552827.0 True False 357106.5485582926 317947.48376405856 249953.43890112886 295280.8022931092 264420.3009624179 328469.21766510117 545587.5290235383 702511.2604604517 416157.69012219086 536865.4480929562 0.6651695500740457 0.5922293656510508 0.465579298852271 0.5500089516693621 0.4925262035425952 0.6118278217230847 1.0162463070804137 1.3085425090325697 0.7751619918928639 1.0 19.034201032494174 -7.247567041850412 4.26988312351661 1.0561294991813723 0.55149475416158 0.7487862129973 0.13111296827013041 0.09568823212169054 4.354642555678954 0.05225096300427145 0.03748504539495801 5.6550045429153674e-08 7.247567041850412 -0.5046347450197923 GYAFIEYEHER ddPTM_A459_Selumetinib_30min_R1 2 GYAFIEYEHER 11 0 P08621;P08621-2;M0QYR1;P08621-3 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 ; 155.26 0.00074744 29204000.0 7794.2 10180.9 10099.4 10795.1 9899.1 8590.3 9198.9 9325.9 5101.0 7710.7 False True 7975.789695126873 8988.915495027992 8727.956952033215 8909.93843412399 9003.728152828056 8503.889381368346 8505.019566923123 9078.546837207527 8656.024437700558 8700.443453578291 0.9167107099404933 1.03315601589607 1.0031623098985383 1.0240786554919263 1.0348585334607319 0.9774087294218197 0.9775386291862176 1.043457943913621 0.9948946262205216 1.0 13.086873220333084 -4.752726500602092 24.99963435184295 1.0101928482544558 0.916710532965474 0.6112540673551781 0.022279009953208882 229.9494235008696 659738.8047315223 0.005596820862835873 0.06456126302529609 1.7671503432300324e-05 4.752726500602092 -0.09348231528898177 GYDDRDYYSR ddPTM_A459_Selumetinib_30min_R2 1 GYDDRDYYSR 10 1 P62995;H7C2L4;P62995-3;H7BXF3 P62995 TRA2B Transformer-2 protein homolog beta 0 134.23 0.0060225 105510000.0 302330.0 291030.0 305990.0 288000.0 354750.0 218260.0 226420.0 221660.0 204580.0 278790.0 False True 285527.70892288117 313351.0651910578 286302.9365367215 248773.90317228885 310183.13349476166 248323.33383298732 236948.9786427182 222304.99390221154 245501.71644279858 270740.6083165898 1.0546172245760788 1.157384801413468 1.0574805837842172 0.9188643872787113 1.1456838167846983 0.9172001768667488 0.8751881740830048 0.8210995582984723 0.9067783291515761 1.0 18.046551767690232 -6.884417089102766 6.375475368600843 0.8874732630453751 1.0625892588380337 0.5463430937307575 0.07374279283126414 0.16076665451606922 8.36510120434504 0.026340771724343386 0.023235450621349848 1.3049170657905284e-07 6.884417089102766 0.17511599579265857 GYDRYEDYDYR ddPTM_A459_Selumetinib_30min_R1 2 GYDRYEDYDYR 11 1 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 0 ; 133.91 0.0048748 29694000.0 5943.0 6404.700000000001 12756.8 15568.3 9619.900000000001 8605.2 7849.3 5597.8 4284.299999999999 4501.9 False True 6081.460336935025 5654.834746535747 11024.496628086545 12849.58865818497 8749.781743531286 8518.639500896465 7257.2209814923135 5449.328159783005 7270.144187108511 5079.762717219466 1.1971937815756606 1.1132084432540308 2.1702778735541166 2.5295647402244232 1.7224784366149875 1.6769758697625452 1.4286535386567687 1.0727525010785994 1.4311975956010803 1.0 12.310545392941828 -7.382033856950769 2.2480766164129378 1.187013623636332 1.7718631738539798 0.2859094294427431 0.4019081106714849 0.4715602390724961 4.653918361682452 0.23561744953858996 0.13973255421673073 4.149216946963397e-08 7.382033856950769 0.5848495502176478 GYDS(ph)EDDTWEPEQHLVNCEEYIHDFNR ddPTM_A459_Selumetinib_30min_R1 1 GYDSEDDTWEPEQHLVNCEEYIHDFNR 27 0 Q9Y232-2;Q9Y232 Q9Y232-2 CDYL Chromodomain Y-like protein 1 GYDS(0.998)EDDT(0.002)WEPEQHLVNCEEYIHDFNR 140.73 1.1241e-12 2369200.0 250.85 268.17 228.79 193.59 347.57 328.74 319.75 317.11 120.83 325.34 True False 256.6943169308686 236.77253173114937 197.7215746535119 159.78314063436773 316.1323548684674 325.43317407203807 295.63100006779814 308.69921268155144 205.03968492596718 367.100558079962 0.6992479615761176 0.6449800375394021 0.5386033071909526 0.4352571444458651 0.8611601042557046 0.8864959938337987 0.8053134040820599 0.840911858854517 0.5585381999917999 1.0 8.520031497452669 -6.277779306449707 24.974846536718665 0.8194990080556565 0.581274902378637 0.49351652201167284 0.12193571940695123 720.5970869349345 1101397.8080846535 0.03816783522241646 0.04340366862475934 5.274978496287919e-07 6.277779306449707 -0.23822410567701946 GYDS(ph)EDDTWEPEQHLVNCEEYIHDFNR ddPTM_A459_Selumetinib_30min_R2 1 GYDSEDDTWEPEQHLVNCEEYIHDFNR 27 0 Q9Y232-2;Q9Y232 Q9Y232-2 CDYL Chromodomain Y-like protein 1 GY(0.002)DS(0.996)EDDT(0.001)WEPEQHLVNCEEYIHDFNR 120.98 4.1383e-12 5176400.0 7259.2 4816.4 8330.4 7883.6 8414.0 5926.4 9665.0 9159.4 7308.2 6509.9 True False 6855.762724880027 5185.802392833076 7794.431133453733 6809.840080031444 7356.95809788562 6742.707805497189 10114.44165083418 9186.052337579704 8770.044208169213 6321.942272248512 1.0844393114715443 0.8202862616441848 1.232917163395974 1.077175302584565 1.1637180127665079 1.066556370673569 1.5998946550387902 1.4530427425609058 1.3872388943928127 1.0 12.626152146237773 -7.236481364292355 24.181249300455256 1.3977976256867872 1.0740624012601083 0.3882007694408973 0.17323357034128864 454.94925951415985 440790.2568116607 0.06407358579430732 0.0496059429933703 5.801210651590877e-08 7.236481364292355 -0.3237352244266789 GYDVIAQAQSGTGK ddPTM_A459_Selumetinib_30min_R2 2 GYDVIAQAQSGTGK 14 0 P60842;P60842-2;J3KT12;J3QS69;J3QL43;J3KTB5;J3QR64;Q14240-2;Q14240;E7EQG2;J3QLN6;J3KS25;J3QKZ9;J3KT04;J3KSN7;E7EMV8;J3KS93 P60842 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 ; 128.57 0.01557 6907500.0 45568.0 45673.0 55886.0 54619.0 64785.0 48190.0 44639.0 40101.0 43061.0 51707.0 False True 43035.512983156994 49175.97223815819 52290.355604076096 47179.79797696959 56646.129114751595 54827.73507473504 46714.801950500434 40217.687270922084 51674.403224867216 50214.08455907986 0.857040676157765 0.9793262721000067 1.0413483799063066 0.9395729981188793 1.1280924388475917 1.0918796101963573 0.9303127272097869 0.8009244343308415 1.0290818537987922 1.0 15.6158044623217 GYEEWLLNEIR ddPTM_A459_Selumetinib_30min_R1 2 GYEEWLLNEIR 11 0 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;F6THM6;A0A494C060 O43707;P12814-4 ACTN4;ACTN1;ACTN2 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2 0 ; 157.97 0.007856100000000001 38478000.0 3055.1000000000004 3883.2000000000003 3089.6 3138.3999999999996 3387.4 3187.0 3180.2 3202.2 2042.3200000000002 2615.3 False True 3126.2778858102292 3428.553138749298 2670.049289957997 2590.3373550643087 3081.010268094045 3154.9416735644745 2940.314953606292 3117.267253788476 3465.6678748489717 2950.999230179271 1.0593963745698132 1.1618278661973815 0.9047949801721208 0.8777831348017491 1.044056615327167 1.0691096226998387 0.9963794376956412 1.05634295729691 1.1744048725619067 1.0 11.52698782907935 -7.99990455227487 13.397067411648353 1.0965929203069822 1.0160779683351802 0.09978007407553835 0.08602149267134729 0.14646909085922094 2888.082546547991 0.05193527647194586 0.023785147213562858 1.0002198006616705e-08 7.99990455227487 -0.08051495197180203 GYES(ph)PTLSK ddPTM_A459_Selumetinib_30min_R1 2 GYESPTLSK 9 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 GYES(0.732)PT(0.268)LSK;GYES(0.769)PT(0.23)LSK 114.89 0.0083395 69749000.0 10020.599999999999 12788.1 9389.3 9620.0 10455.0 9113.0 10213.5 9630.8 5055.3 8750.4 True False 10254.060483306606 11290.863306973599 8114.284631733112 7940.047589765054 9509.347095980176 9021.331493941974 9443.087472063975 9375.359898752751 8578.474875496495 9873.599076113907 1.0385332039775756 1.1435407919578504 0.8218162970950575 0.8041695362103087 0.9631084898904874 0.913682176519226 0.9563977025265872 0.9495382409676234 0.8688295736302923 1.0 13.269360349363797 -5.2550091722565915 24.99725176452774 0.9078400778540053 1.0910370074341986 0.5627500436180649 0.06392304841910311 363.08360361321417 1411467.6846529322 0.016775079528185733 0.0421822743073189 5.558925167513394e-06 5.2550091722565915 0.1831969295801933 GYES(ph)PTLSK ddPTM_A459_Selumetinib_30min_R2 1 GYESPTLSK 9 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 GYES(0.657)PT(0.343)LSK 133.81 0.0030341 36158000.0 155040.0 126600.0 124650.0 142870.0 140130.0 107500.0 128970.0 123620.0 108920.0 115500.0 True False 146423.49747429465 136309.81291683976 116630.15470865848 123410.85953550336 122525.61662190536 122307.14921216042 134967.36054920693 123979.71373360734 130707.04347907705 112165.2148949607 1.3054269776188256 1.215259232057726 1.0398068137067187 1.1002596451232574 1.0923673327479189 1.090419604034079 1.2032907053724253 1.1053312192172104 1.1653081893658404 1.0 16.77526580564728 -5.020326206111838 4.096481364360137 1.106742450784615 1.2934233059161375 0.6009147008487359 0.0543957964054039 0.1330642415187991 5.127285549832781 0.01374643169132605 0.05117093839716501 9.542755438648158e-06 5.020326206111838 0.18668085513152244 GYESFGVHR ddPTM_A459_Selumetinib_30min_R2 2 GYESFGVHR 9 0 E9PGM4;Q04446 E9PGM4 GBE1 1,4-alpha-glucan-branching enzyme 0 ; 144.12 0.00082166 0.0 22999.2 17435.3 27039.0 36544.0 33597.0 28221.0 25247.2 28524.0 26580.0 28844.0 False True 21720.996537092353 18772.531446674388 25299.340177837264 31566.644158083785 29376.24449900918 32108.18658526865 26421.244826377697 28607.000117597603 31896.742707251837 28011.198774287805 0.7754397343761885 0.670179509200662 0.903186628380224 1.126929426064393 1.0487321423021132 1.1462624946541586 0.9432386324940307 1.0212701122901138 1.138713946670882 1.0 14.773716106221858 -5.501611331644837 3.7936813501105444 1.0590267910789823 0.7274330397519045 0.8069819166502831 0.06608593465180863 0.0873045645365465 2.721655105974369 0.01796189962961379 0.03728559115681656 3.1505666270745433e-06 5.501611331644837 -0.3315937513270778 GYESPTLSKDY(ph)EGYPAPAMPDFQPGDTTVR ddPTM_A459_Selumetinib_30min_R1 1 GYESPTLSKDYEGYPAPAMPDFQPGDTTVR 30 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 GY(0.002)ES(0.062)PT(0.204)LS(0.204)KDY(0.497)EGY(0.018)PAPAMPDFQPGDT(0.006)T(0.006)VR 68.93 0.0029734 4204000.0 924.41 515.65 2108.3 2112.1 1544.3 880.79 927.19 615.34 533.4 484.91 True False 945.9469544112582 455.2774582808187 1822.0044400629356 1743.2613840273148 1404.6183376683098 871.9300522933332 857.2513118150487 599.0191842939857 905.1408420053867 547.1529219233855 1.7288529705479911 0.8320844868750759 3.32997296927176 3.18605880399815 2.567140339360172 1.5935765256050745 1.5667490338927301 1.094792991670915 1.6542739803409623 1.0 9.095800293117074 -6.887980411114397 4.436393456402021 1.3659928471689435 2.346383815272526 0.3249646063745434 0.6882550590363057 0.3056640735380403 10.4481035975382 0.27746684815272843 0.24386166382547209 1.2942542175682632e-07 6.887980411114397 0.9803909681035823 GYFEYIEENK ddPTM_A459_Selumetinib_30min_R2 2 GYFEYIEENK 10 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 ; 168.83 0.003515 3721800.0 27059.0 19601.2 25493.0 25699.0 23153.0 19985.0 26009.0 24607.0 22284.0 23517.0 False True 25555.169105759393 21104.549012208223 23852.808134679723 22198.75186675226 20244.313149553804 22737.75234423281 27218.470035855782 24678.60229609186 26741.422666982693 22838.003105495987 1.1189756384440424 0.9240978256601337 1.0444349282420196 0.9720093199133557 0.8864309657914877 0.9956103534621619 1.1918060397016774 1.080593700863143 1.170917726188913 1.0 14.479148890331466 -7.162825945896384 7.446876658948758 1.1172240415858572 0.9834074097473474 0.3701950472435548 0.07664584040882833 0.26615320831656325 17.662026452129435 0.028163009196613256 0.021787336566400365 6.873438546311676e-08 7.162825945896384 -0.13381663183850978 GYFSEEMNR ddPTM_A459_Selumetinib_30min_R2 1 GYFSEEMNR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 136.27 0.036769 4908500.0 20113.0 16289.0 17028.0 19246.0 22597.0 17655.0 15868.0 17192.0 13197.0 13738.0 False True 18995.19997871831 17538.31392260983 15932.437018684606 16624.66159879817 19758.162840256864 20086.815993866912 16605.8934418455 17242.025873711194 15836.768754988801 13341.348244389339 1.4237841356631014 1.3145833240643807 1.1942149119287806 1.2461005660196014 1.480971973620889 1.505606152085443 1.2446937998810619 1.2923750701854495 1.187044102656484 1.0 13.703616848711173 -8.537983913789605 1.2389174920779757 1.001991142393428 1.3456941657349268 0.5583499627670747 0.09614611550190301 0.4244905746756447 1.4272922852007492 0.10116870453027912 0.03130864255956632 2.8974509069136463e-09 8.537983913789605 0.3437030233414988 GYFVQPTVFSNVT(ph)DEMR ddPTM_A459_Selumetinib_30min_R2 2 GYFVQPTVFSNVTDEMR 17 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 GYFVQPT(0.027)VFS(0.108)NVT(0.865)DEMR;GYFVQPT(0.007)VFS(0.054)NVT(0.939)DEMR 122.16 0.0032733000000000003 5295100.0 30792.4 26081.6 30169.3 30006.9 32437.4 23056.7 21915.1 31081.0 25767.7 27380.0 True False 29081.081679743755 28081.974854438005 28228.240083850204 25919.908455210272 28362.323817964705 26232.551137116472 22934.195573946814 31171.44056426345 30921.960009693496 26589.46825821662 1.093706778839294 1.056131494685313 1.0616323654809146 0.9748186087625336 1.0666751039370725 0.986576748446639 0.8625293048821967 1.1723228257726033 1.1629401426686319 1.0 14.698567305714395 -9.45309362965425 0.0018275625589939085 0.5911902015330522 1.4867153626596057 0.0012003847878080398 0.08770089037605848 3748005.973556683 2162.209772398099 533088.2106590609 526409.9808161831 3.522949115080291e-10 9.45309362965425 0.8955251611265534 GYFVQPTVFSNVTDEMR ddPTM_A459_Selumetinib_30min_R1 1 GYFVQPTVFSNVTDEMR 17 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 319.64 2.1061999999999984e-117 23884000.0 2285.6 2578.1 2820.5 2995.5 3054.9 2807.8 2841.9 2755.8 1709.9 1822.2 False True 2338.8500329965836 2276.254853473827 2437.4915918975066 2472.392157499087 2778.5848343864013 2779.5560812784242 2627.5331949731844 2682.707231900033 2901.575413845165 2056.0971197310705 1.1375192399970369 1.10707555184531 1.1854943857011584 1.20246856715721 1.3513879318841853 1.3518603059188077 1.2779227059648115 1.3047570594578337 1.411205427020237 1.0 11.005692696492122 -5.896163634761947 2.1700478477621266 1.300413281112792 1.1312649752924024 0.25054231913054037 0.10585761978847304 0.35809626383661225 3.428491603251383 0.03077439865332826 0.0522713502886668 1.2700954647092217e-06 5.896163634761947 -0.16914830582038953 GYFVQPTVFSNVTDEMR ddPTM_A459_Selumetinib_30min_R2 2 GYFVQPTVFSNVTDEMR 17 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 124.38 0.018191 19971700.0 40884.0 42050.0 42246.0 47540.0 45999.0 34243.0 29605.0 32808.0 29249.0 39557.0 False True 38611.83095161933 45275.0997879393 39527.93835396699 41064.96998892574 40220.194383722446 38959.662422995454 30981.691161194594 32903.465848343236 35099.61728534267 38414.88662857103 1.0051267709040126 1.1785821529476022 1.028974489399329 1.0689858435865776 1.0469950041140748 1.0141813719168769 0.8065022151634308 0.8565290369455709 0.913698317652651 1.0 15.229377875477503 -7.0704618496578755 4.414690623890546 0.8828353876676932 1.0676127532936548 0.6215255131372102 0.06296520394678425 0.1350863845341156 5.0269967482517535 0.02386759476057223 0.018639762891056785 8.502333781557347e-08 7.0704618496578755 0.1847773656259616 GYIFLEYAS(ph)PAHAVDAVK ddPTM_A459_Selumetinib_30min_R1 2 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 GYIFLEY(0.002)AS(0.998)PAHAVDAVK;GYIFLEY(0.011)AS(0.989)PAHAVDAVK 126.25 0.0005199 17270400.0 4859.7 5751.0 6793.799999999999 6654.200000000001 6332.200000000001 5362.5 5767.799999999999 5635.1 2873.2 4969.0 True False 4972.921554669887 5077.670246432637 5871.239275672139 5492.168884804019 5759.453628040709 5308.558118760432 5332.730202317577 5485.638842615526 4875.6105497748 5606.819552158759 0.8869416089474815 0.9056239815097338 1.0471603769398237 0.9795515681772573 1.0272229335119556 0.9468038108550347 0.9511150042744553 0.9783869075121965 0.8695857793207514 1.0 12.452966924040979 -5.030170882797025 22.92321749021152 0.9745114834304607 0.8916121362396229 0.3229188378189687 0.0459268680688476 238.76197315197774 181408.52998420724 0.011715790000764604 0.031136841558288428 9.328871634256633e-06 5.030170882797025 -0.0828993471908378 GYISPYFINTSK ddPTM_A459_Selumetinib_30min_R2 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 153.95 0.011977 0.0 9394.8 8560.8 8997.4 12766.0 9871.6 7613.9 10692.0 8188.4 7886.0 7366.9 False True 8872.674626364185 9217.385832689431 8418.51707962843 11027.248777421664 8631.441354776287 8662.645612897379 11189.199185796071 8212.226888337402 9463.420353250105 7154.198455495105 1.2402052698928316 1.288388334490442 1.1767240078673253 1.5413674705866858 1.2064861505409483 1.2108478212878822 1.564004584916386 1.1478891645827396 1.322778563122092 1.0 12.804574423513467 -9.535408450473744 1.0768856291582016 0.9978957872417371 1.3038831489931348 0.30003303827600847 0.13699833728287406 12.541578624809649 12.03701204111784 0.22876011099280633 0.03951190633381749 2.914684487179783e-10 9.535408450473744 0.30598736175139774 GYLPSHYER ddPTM_A459_Selumetinib_30min_R2 2 GYLPSHYER 9 0 Q6P2Q9;I3L1T8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 ; 94.309 0.032895 4896600.0 21602.4 19797.2 26701.0 27711.0 29681.0 20395.0 20454.9 19933.0 19632.6 22696.0 False True 20401.825089258902 21315.581581968894 24983.0867298507 23936.71399585867 25952.207428493337 23204.226122623375 21406.09338061542 19991.001729914202 23559.6685806769 22040.70750871017 0.9256429305273615 0.9671006057108323 1.133497494124349 1.08602294125083 1.1774670762377932 1.0527895310735103 0.9712071798129004 0.9070036305329149 1.0689161666596436 1.0 14.427882914843492 -7.226068622766714 6.355284536653765 0.9789799650969703 1.0635930579771717 0.15846812907723884 0.07781348586062392 0.35345745123694244 44.86435980877142 0.03267390116693915 0.02476461701793526 5.941982620728926e-08 7.226068622766714 0.08461309288020147 GYNHGQGSYSYSNSYNS(ph)PGGGGGSDYNYESK ddPTM_A459_Selumetinib_30min_R1 1 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK 31 0 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 GYNHGQGSYSYSNS(0.005)Y(0.019)NS(0.975)PGGGGGSDYNYESK 129.93 2.8441e-18 13984000.0 1502.7 1452.6 1223.0 1174.3 2247.3 1421.7 2116.6 1445.5 396.06 941.88 True False 1537.709986254798 1282.5289167045805 1056.9233174581284 969.2305493410711 2044.032111793041 1407.3989888003182 1956.943157915564 1407.1606443542698 672.0848929221102 1062.779472688124 1.446875881376798 1.2067686191384905 0.9944897738613793 0.9119771074327992 1.9232890400329254 1.3242624880969298 1.8413445199179481 1.3240382229015872 0.6323841494813436 1.0 10.05362655258899 -8.208242888294329 7.810666625581521 0.8176426102711101 1.3717051676149443 0.3344255023498779 0.31353842235750395 0.32291710999816864 43.44804770498392 0.22690007367758688 0.08429963795116652 6.190947365260518e-09 8.208242888294329 0.5540625573438342 GYNHGQGSYSYSNSYNS(ph)PGGGGGSDYNYESK ddPTM_A459_Selumetinib_30min_R2 2 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK 31 0 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 GYNHGQGSYSYSNS(0.008)Y(0.017)NS(0.975)PGGGGGSDYNYESK;GYNHGQGSYSYSNS(0.034)Y(0.128)NS(0.838)PGGGGGSDYNYESK 155.68 4.5407e-23 56110000.0 106763.0 79524.0 143985.0 165517.0 203417.0 135862.0 121170.0 155441.0 151722.0 155343.0 True False 100829.53986615148 85623.23509003781 134721.16185901465 142973.29906724909 177861.93788894688 154575.75726755874 126804.64509380002 155893.30757535706 182070.6394668794 150857.84396041403 0.66837452544138 0.5675756251196712 0.893033854403794 0.9477352672809384 1.1790035785982655 1.0246451441273436 0.840557187911782 1.0333788650477091 1.2069020389463858 1.0 17.20283018682187 -5.472476186001051 2.2678392023736826 1.0346005790799728 0.6109846094474564 0.7195846797975185 0.10217950940216752 0.16858124875389516 1.6848201400142602 0.030465990496255566 0.07853770648758882 3.369176896983821e-06 5.472476186001051 -0.42361596963251646 GYPHWPAR ddPTM_A459_Selumetinib_30min_R1 2 GYPHWPAR 8 0 O75475-3;O75475-2;O75475;H3BPQ6;M0R0J3;P51858;Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;Q9Y3E1 O75475-3;P51858;Q7Z4V5-2;Q9Y3E1 PSIP1;HDGFRP3;HDGFRP2;HDGF PC4 and SFRS1-interacting protein;Hepatoma-derived growth factor;Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 ; 131.04 0.005156100000000001 19722200.0 14454.4 18018.699999999997 14904.8 17281.5 15559.2 14744.6 15825.2 13812.3 8524.9 13605.8 False True 14791.159396633631 15909.06222733363 12880.810026205967 14263.6104389319 14151.873107199866 14596.282711025657 14631.492423058384 13445.952935326506 14466.132665938747 15352.236961714962 0.9634530416329209 1.0362699759655396 0.8390184478215013 0.9290900390934655 0.9218117947561301 0.9507593419399085 0.9530528000281683 0.875830210858372 0.9422817470844177 1.0 13.906161264359314 -5.235327095223088 24.97943843225023 0.9237884627786708 0.9998615068075795 0.3006816502607257 0.04461295121156936 849.4496285088012 812594.4991821786 0.01077169932042425 0.028479628056256156 5.816649633022122e-06 5.235327095223088 0.07607304402890869 GYPSPGAHS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 GYPSPGAHSPR 11 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5 Q63HR2-6 TNS2 Tensin-2 1 GYPSPGAHS(1)PR;GYPSPGAHS(1)PR 104.81 0.0079765 4301800.0 3109.4 3668.6 3891.3 4352.700000000001 4425.8 3448.2 4225.0 3141.0 1346.19 2508.35 True False 3181.8429701608247 3239.0786065141297 3362.8828333808788 3592.5826552983763 4025.4871714384567 3413.514238715101 3906.3048484329843 3057.690476594093 2284.3861081725395 2830.321155898052 1.1241985608347813 1.1444208724385485 1.1881629850990696 1.2693197900216595 1.4222722262630236 1.2060519109648542 1.3801631098621832 1.0803333996999707 0.807111978586653 1.0 11.466750049285853 -8.003047715861166 5.604639996786194 0.9123853799557419 1.2472233005979236 0.6596619509212396 0.09935988178514252 0.09844812383071294 10.938766939941226 0.06453556274533916 0.027135901471826557 9.930069409228276e-09 8.003047715861166 0.33483792064218176 GYPSPGAHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 GYPSPGAHSPR 11 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5 Q63HR2-6 TNS2 Tensin-2 1 GYPSPGAHS(1)PR 115.83 0.004012 1809300.0 15320.0 15603.0 17698.0 22899.0 24349.0 14779.0 13469.0 15627.0 17101.0 24274.0 True False 14468.575730819095 16799.699928447495 16559.329948125433 19780.116697021687 21290.060937178143 16814.67309959554 14095.335188317174 15672.471982810881 20521.677841862806 23573.14654857377 0.6137736301348569 0.7126626008043001 0.7024658296678391 0.8390953094133472 0.903148881432048 0.7132977799526243 0.5979403368690284 0.6648442943548875 0.8705531864223875 1.0 14.524856722229275 -8.504130788515 4.028853927240233 0.9992052113185725 0.724464622175143 0.5156940128924328 0.08829431480490478 0.16493233739454047 7.12888437484886 0.09501923030952893 0.02490643297236259 3.132342272108439e-09 8.504130788515 -0.2747405891434296 GYRDDRS(ph)PAREPGDVSAR ddPTM_A459_Selumetinib_30min_R1 1 GYRDDRSPAREPGDVSAR 18 3 A0A1W2PR91;A0A1W2PQT1;C9J366;P0DPB3-2;P0DPB3;B3KU38-2;B3KU38 A0A1W2PR91 IQCJ-SCHIP1 1 GY(0.184)RDDRS(0.816)PAREPGDVSAR 60.541 0.034407 16165000.0 390.12 540.46 624.96 590.52 756.87 482.64 443.73 363.41 205.36 372.62 True False 399.20903695862245 477.1826919469624 540.0938646595517 487.39676743327044 688.411242136252 477.78507980205757 410.25908885092724 353.7711862779557 348.48092109903655 420.4494066261615 0.9494817465959116 1.1349348683258929 1.2845632700339877 1.1592281015314514 1.637322425212378 1.1363675920867111 0.975763272311394 0.8414120241404167 0.8288296180398347 1.0 8.715788398814205 -7.2765375223643005 3.2115104046888896 0.885731938871649 1.2372765173039257 0.4458885097458083 0.16926413318940403 0.23863445807069122 5.098854106783099 0.07842871832823498 0.053292725868703456 5.290082897458523e-08 7.2765375223643005 0.3515445784322767 GYS(ph)FSLTTFSPSGK ddPTM_A459_Selumetinib_30min_R2 1 GYSFSLTTFSPSGK 14 0 A0A024RA52;P25787;H3BT36 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 GYS(0.544)FS(0.425)LT(0.011)T(0.021)FSPSGK 170.11 0.00016531 5195200.0 44136.0 45987.0 52557.0 53262.0 54387.0 44247.0 37822.0 48515.0 43676.0 50005.0 True False 41683.09781040677 49514.05502848906 49175.53983973495 46007.62371792518 47554.41883405099 50341.622615725275 39580.79794287122 48656.17061790941 52412.42040940297 48561.225721406954 0.8583617318380796 1.019621195571719 1.0126503009181087 0.9474147951262258 0.9792672678170861 1.0366629315440339 0.8150699937012309 1.00195515856719 1.0793059613052214 1.0 15.56751721629704 -4.75089931031937 24.574017981346604 0.9834019760189954 0.8583614045327287 0.2514047395421063 0.06668519419986818 552.1500352603615 1287222.6320884563 0.0167263210528221 0.22980448804905731 1.7746008683014417e-05 4.75089931031937 -0.12504057148626668 GYS(ph)FTTTAER ddPTM_A459_Selumetinib_30min_R1 3 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 GYS(0.366)FT(0.366)T(0.267)TAER;GYS(0.304)FT(0.304)T(0.304)T(0.088)AER;GYS(0.496)FT(0.496)T(0.007)TAER 173.64 0.00010779 72012000.0 3935.5 4650.0 4885.8 5979.0 6397.6 4459.0 5316.599999999999 6832.599999999999 2419.9900000000002 4188.280000000001 True False 4027.189492850044 4105.5758382736485 4222.33519577835 4934.879889730276 5818.938209588017 4414.146508448066 4915.564581580783 6651.377252587324 4106.5462809235405 4725.88653530197 0.8521553496401747 0.8687419402910642 0.8934482798598454 1.0442231003362317 1.2312902914873314 0.934035651401016 1.0401359712853735 1.4074348173410645 0.868947286450487 1.0 12.206369276453271 -5.78808297601832 3.59007066403902 1.0947422215149494 0.8656740837552693 0.2976812245449961 0.1434646792526989 0.26285229297147283 7.112873884748023 0.040175639977118656 0.06675703918713197 1.6289847701461543e-06 5.78808297601832 -0.22906813775968005 GYS(ph)FTTTAER ddPTM_A459_Selumetinib_30min_R2 3 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 GYS(0.437)FT(0.437)T(0.126)TAER;GYS(0.475)FT(0.475)T(0.039)T(0.011)AER;GYS(0.497)FT(0.497)T(0.006)TAER 155.53 0.00052381 72661000.0 135481.0 114161.0 143188.0 140959.0 143895.0 111471.0 120058.0 126560.0 108074.0 136483.0 True False 127951.50839341409 122916.78161452882 133975.43997130645 121760.14103216208 125817.62366237839 126825.11841701157 125640.93489041376 126928.26864686419 129691.81983986223 132542.3811645789 0.9653629825356443 0.9273771946340854 1.0108120798354159 0.9186506230107001 0.9492633417091676 0.9568646443701041 0.9479302679375018 0.9576428877436296 0.9784932087407039 1.0 17.016094217656047 -8.466933296045378 2.113926657352388 0.9997605568806832 0.9534060023378307 0.2896815488232539 0.023215565641293425 0.37294576696392645 3.675729487266229 0.021020565763911883 0.005863757356600754 3.4124531998841864e-09 8.466933296045378 -0.04635455454285253 GYS(ph)PHQHPR ddPTM_A459_Selumetinib_30min_R2 1 GYSPHQHPR 9 0 Q13796 Q13796 SHROOM2 Protein Shroom2 1 GY(0.006)S(0.994)PHQHPR 92.866 0.016752 2765400.0 25140.0 25202.0 22566.0 28074.0 26715.0 17550.0 18686.0 21891.0 20874.0 26357.0 True False 23742.81944339374 27134.91236279777 21114.12812800308 24250.272769648735 23358.82286486978 19967.353196962024 19554.93602560655 21954.69918574986 25049.383268290992 25596.004926289836 0.9275986432948106 1.0601229543805608 0.8248993617873785 0.9474241327692944 0.9125964357382105 0.7800964742139667 0.763983913970947 0.8577392936504726 0.9786442587594049 1.0 14.643631028727505 -5.266576355529532 24.99166339702442 0.8734997091500984 0.9938607995651034 0.22177602395470086 0.08133921998149125 531.1764351373637 2584213.4381637047 0.021656265746777287 0.04736774642603644 5.4128207395226295e-06 5.266576355529532 0.12036109041500498 GYSFT(ph)TTAER ddPTM_A459_Selumetinib_30min_R2 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 GYS(0.308)FT(0.681)T(0.011)TAER 115.57 0.015446 10502000.0 27979.0 15349.0 26246.0 22679.0 23901.0 25460.0 27951.0 24456.0 16875.0 20777.0 True False 26424.039188811203 16526.21894518622 24557.36093448415 19590.081076542843 20898.342702348968 28966.88389713123 29250.776883855782 24527.16291109125 20250.471526895213 20177.114024870963 1.309604493300681 0.8190576176957453 1.2170898625152216 0.9709060003524526 1.035744887826326 1.4356306784719415 1.4497007276561122 1.2155932152070053 1.0036356786175578 1.0 14.300432217038539 -6.716124526587485 24.998677861507637 1.2486864895517311 1.059125439131718 0.12886864132247644 0.18761647558920516 217.17093423542605 119805.1357389084 0.061387356961945964 0.061387134024088644 1.9225403939730817e-07 6.716124526587485 -0.18956105042001314 GYSFTT(ph)TAER ddPTM_A459_Selumetinib_30min_R1 3 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 GYS(0.004)FT(0.023)T(0.969)T(0.004)AER;GYS(0.211)FT(0.18)T(0.609)TAER;GYSFT(0.018)T(0.979)T(0.003)AER 166.97 0.00072508 67072000.0 10768.7 16299.5 14074.8 17814.199999999997 14589.8 12318.4 13103.3 15655.8 6599.91 11020.1 True False 11019.589757757396 14391.146962568033 12163.519467342325 14703.284383949345 13270.155166038398 12194.488080212315 12114.907531472652 15240.557326794591 11199.565231645616 12434.6371798641 0.8862011491257545 1.1573435359957416 0.9781965723164961 1.1824457900355112 1.067192791722728 0.9806870842970258 0.9742871751088003 1.2256535599988578 0.9006748704965446 1.0 13.602076792496531 GYSFTTTAER ddPTM_A459_Selumetinib_30min_R1 2 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ; 141.52 0.018002 276300000.0 7332.4 8240.0 8683.8 9414.8 7474.4 7014.299999999999 7303.1 7491.5 4120.299999999999 5934.3 False True 7503.230653633249 7275.256969327925 7504.587656699008 7770.6819176839945 6798.341839712499 6943.742510474834 6752.221287240461 7292.801084178487 6991.848165194589 6696.025209977001 1.1205499409490753 1.0865038199808261 1.120752598947396 1.1604917356203748 1.0152802037816475 1.0369946785936135 1.0083924530600226 1.0891238989531127 1.044178889108245 1.0 12.709089244187192 -6.2701393715406954 24.999898762767323 1.035821068203968 1.119439336745155 0.702516135735445 0.028535654790390524 385.25004643880226 1107034.9899850106 0.009071500353797361 0.010430495353904891 5.368594825520545e-07 6.2701393715406954 0.08361826854118704 GYSFTTTAER ddPTM_A459_Selumetinib_30min_R2 3 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ;; 217.64 0.0023975000000000003 304653000.0 152369.0 154546.0 173384.0 182482.0 216645.0 134920.0 138617.0 141182.0 134890.0 169401.0 False True 143900.9409614344 166399.18125628692 162228.66220622548 157627.6368009921 189428.1182691264 153504.00531818325 145062.96516437465 141592.8162460616 161871.76914150515 164509.95297334366 0.8747248319057713 1.0114839755820086 0.9861328100465274 0.958164742935239 1.1514690439417994 0.9330985909591515 0.881788381447534 0.8606945275159403 0.9839633786032023 1.0 17.32781534515057 -6.974079292092674 24.999686282086824 0.918208464821503 0.9993137616588372 0.1460703827260318 0.07505768718164882 352.4149679891629 339891.893001174 0.026245026209590946 0.023145261669209688 1.0615017339256682e-07 6.974079292092674 0.08110529683733425 GYSS(ph)LLK ddPTM_A459_Selumetinib_30min_R2 1 GYSSLLK 7 0 P17844-2;P17844;J3KTA4 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 1 GYS(0.116)S(0.884)LLK 80.219 0.0453 2463300.0 28925.0 29070.0 41831.0 24795.0 35106.0 27419.0 31315.0 30790.0 25934.0 30073.0 True False 27317.46429594925 31299.575525217497 39139.639002149124 21417.87822623924 30695.670428378024 31195.718365099798 32771.20954949531 30879.593802441093 31121.524656503712 29204.71435096234 0.9353785819531256 1.0717302401619322 1.3401822230409666 0.7333705773956146 1.05105189728954 1.068174062249366 1.122120530119667 1.0573496262059336 1.0656335919778723 1.0 14.833913653509931 -6.517882495984404 24.939835122678048 1.0688072136190239 1.0273950082619883 0.01776554212329473 0.1422804746269447 1326.189335548866 6619977.619108708 0.047136819700241625 0.048349058518609565 3.034712153935602e-07 6.517882495984404 -0.0414122053570356 GYT(ph)SDDDTWEPEIHLEDCK ddPTM_A459_Selumetinib_30min_R1 3 GYTSDDDTWEPEIHLEDCK 19 0 Q99549-2;Q99549 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GYT(0.5)S(0.5)DDDT(0.001)WEPEIHLEDCK;GY(0.056)T(0.315)S(0.315)DDDT(0.315)WEPEIHLEDCK;GYT(0.425)S(0.425)DDDT(0.15)WEPEIHLEDCK 136.53 0.00023573 31675600.0 1853.8200000000002 2866.6099999999997 2683.9300000000003 2416.98 2202.4 2898.0699999999997 2158.57 2223.41 1265.74 2149.89 True False 1897.0103990942105 2530.985968549167 2319.467047772195 1994.8998153337175 2003.1933088653013 2868.9180470370234 1995.7473270253229 2164.4379441464716 2147.8683340080597 2425.84932320197 0.7819984452250625 1.0433401383761227 0.9561463795742446 0.8223510818473152 0.8257698817918381 1.1826447832506886 0.822700448843649 0.8922392349123928 0.8854087982566895 1.0 11.244274227774987 GYT(ph)SDDDTWEPEIHLEDCK ddPTM_A459_Selumetinib_30min_R2 4 GYTSDDDTWEPEIHLEDCK 19 0 Q99549-2;Q99549 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GYT(0.575)S(0.425)DDDTWEPEIHLEDCK;GYT(0.531)S(0.468)DDDT(0.001)WEPEIHLEDCK;GYT(0.5)S(0.5)DDDTWEPEIHLEDCK;GY(0.087)T(0.449)S(0.449)DDDT(0.015)WEPEIHLEDCK 192.64 3.723e-15 22991700.0 158718.3 136308.0 151161.0 152890.0 136542.7 126552.7 154549.0 157943.0 133161.0 128947.6 True False 149897.3722856962 146762.3853007001 141435.46583165287 132066.11825003923 119388.98531877439 143984.18569397007 161735.83473303373 158402.5879811288 159796.92082920807 125224.5477418999 1.197028657629089 1.171993734033616 1.129454794463824 1.054634419780381 0.9533992134261632 1.149807991247336 1.2915665310797302 1.2649483734420195 1.2760830341233511 1.0 16.934157875637766 -7.007689282198898 24.90601478856405 1.2288654932554517 1.098941134447323 0.19286170645942247 0.09943679814458674 479.91601429977356 1554477.184522397 0.03656649300270029 0.03091863784842554 9.82450590012416e-08 7.007689282198898 -0.1299243588081287 GYT(ph)SDSEVYTDHGR ddPTM_A459_Selumetinib_30min_R2 1 GYTSDSEVYTDHGR 14 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.94)S(0.059)DS(0.001)EVYTDHGR 135.47 0.0008176 8597800.0 13505.0 7493.3 12010.0 13556.0 21716.0 15424.0 18009.0 19823.0 14092.0 12807.0 True False 12754.446164798424 8068.012015242943 11237.289675499298 11709.649414595651 18987.841936496796 17548.51599486849 18846.454184156504 19880.681648125697 16910.793763378202 12437.228633417832 1.0255054836354986 0.6486985367113735 0.90352039081324 0.9414998919560558 1.5266939682589733 1.4109667444495664 1.5153258607401974 1.5984816420201449 1.359691476438751 1.0 13.602377427537927 -6.182047918921071 4.493739243224947 1.4379619861827344 0.8517820453234008 0.6723411708359648 0.1776861783561941 0.11776587521804091 4.3832888028379 0.050795982095754116 0.06606830816610584 6.575852771070719e-07 6.182047918921071 -0.5861799408593336 GYT(ph)SDSEVYTDHGRPGK ddPTM_A459_Selumetinib_30min_R1 3 GYTSDSEVYTDHGRPGK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.473)S(0.473)DS(0.055)EVYTDHGRPGK;GYT(0.546)S(0.453)DS(0.001)EVYTDHGRPGK;GYT(0.814)S(0.183)DS(0.003)EVYTDHGRPGK 131.48 0.00044303 340828000.0 17535.199999999997 20362.9 21274.5 24042.5 21075.8 18491.3 20446.0 18315.0 9204.6 15618.300000000001 True False 17943.736042440356 17978.802201544615 18385.539752463566 19843.92870862021 19169.4976112347 18305.29431075707 18903.741758830954 17829.22670449563 15619.533922614892 17623.060940124993 1.0181963339629176 1.0201861221854855 1.0432659692279975 1.126020546376177 1.0877507418469348 1.038712535407441 1.0726707365455481 1.0116986353886588 0.8863122005696309 1.0 14.105176906509817 -8.024988295936794 5.140049760898317 0.9430695702230502 1.0583742050350984 0.5687676383930513 0.039805070301274025 0.13528305407972152 9.906330295877728 0.027246468838400505 0.010716306218151422 9.440863186931289e-09 8.024988295936794 0.11530463481204822 GYT(ph)SDSEVYTDHGRPGK ddPTM_A459_Selumetinib_30min_R2 2 GYTSDSEVYTDHGRPGK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.911)S(0.089)DSEVYTDHGRPGK;GYT(0.455)S(0.455)DS(0.091)EVYTDHGRPGK 110.12 0.0012287 337541000.0 147499.0 120337.0 135028.0 148958.0 151814.0 98666.0 110300.0 119195.0 93517.0 131841.0 True False 139301.5960652797 129566.46095555871 126340.44548737045 128669.66343311736 132741.76808561993 112256.34589922802 115429.1685553035 119541.83771620544 112223.01308329847 128034.40776594337 1.0880012529126828 1.011965948969093 0.986769476204634 1.0049616011684552 1.0367663693050542 0.8767670180069186 0.9015480336060663 0.9336696267985791 0.8765066753653492 1.0 16.96617204437006 -6.754789155584485 24.999760297776056 0.9125432296595267 1.021616179157706 0.629744818522266 0.04125019779483462 100.28846583774413 377007.79717829585 0.013395352489972711 0.013102135115173035 1.7587772705890185e-07 6.754789155584485 0.10907294949817936 GYTS(ph)DDDTWEPEIHLEDCK ddPTM_A459_Selumetinib_30min_R2 1 GYTSDDDTWEPEIHLEDCK 19 0 Q99549-2;Q99549 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GYT(0.161)S(0.839)DDDTWEPEIHLEDCK 185.23 2.0043000000000002e-14 8564100.0 56452.0 44227.0 48267.0 51604.0 49291.0 42938.0 51354.0 58059.0 40609.0 46010.0 True False 53314.623835261096 47619.068687781 45161.55376913611 44575.44617813472 43098.623912869036 48852.31974764414 53742.06275602051 58227.94207781514 48731.93471026294 44681.57175166353 1.1932128111244464 1.0657429186341931 1.010742281407205 0.9976248469029101 0.9645726912295659 1.0933438066852545 1.202779146953792 1.3031757790760186 1.0906495183542557 1.0 15.44739231555974 -7.0546950494071305 5.116107035411337 1.172620905750784 1.041369913822655 0.19466746832542947 0.09326743679114302 0.27397003733820247 15.449709759162868 0.03614263678938406 0.028395676996960866 8.816677404777335e-08 7.0546950494071305 -0.13125099192812884 GYTS(ph)DSEVYTDHGR ddPTM_A459_Selumetinib_30min_R1 2 GYTSDSEVYTDHGR 14 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.034)S(0.962)DS(0.004)EVYTDHGR;GYT(0.291)S(0.709)DSEVYTDHGR 152.16 0.00038786 7716600.0 3085.8 3246.3 2596.6000000000004 2679.5 3459.5 2907.3999999999996 3688.3 3662.4 1626.71 2578.8 True False 3157.693136078428 2866.221686836075 2243.995982102841 2211.575625444437 3146.588835824333 2878.1541957079867 3410.088561532636 3565.261254848204 2760.408059802367 2909.8140996391626 1.085187241504536 0.9850188323685375 0.7711819055317356 0.7600401777277414 1.0813710869758077 0.9891196128525523 1.1719266058802558 1.2252539621999636 0.9486544381459547 1.0 11.506711270752445 -6.298189674882813 22.73162475208623 1.0817640099781505 0.8971775440892615 0.32652831568399865 0.11808920948909728 229.8864829652754 142193.58420547337 0.039034009293009105 0.04426294092454782 5.032807566571151e-07 6.298189674882813 -0.18458646588888894 GYTS(ph)DSEVYTDHGR ddPTM_A459_Selumetinib_30min_R2 1 GYTSDSEVYTDHGR 14 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.005)S(0.76)DS(0.226)EVYT(0.009)DHGR 143.58 0.00053682 9058500.0 28939.0 23200.0 30704.0 33851.0 34785.0 29503.0 29974.0 33423.0 26562.0 34200.0 True False 27330.68623199568 24979.36540024236 28728.538067987556 29240.435403767897 30414.997318154416 33566.77044843135 31367.85039235422 33520.2553965245 31875.142204289783 33212.557137728574 0.8229021968606192 0.7521060572558707 0.8649902489848548 0.8804030139116131 0.9157680088295217 1.0106650418163798 0.9444575514699283 1.0092645157528803 0.9597316482469962 1.0 15.019441184229755 -5.9954661928345185 0.9878441140142236 0.9859864341684765 0.7823848316202079 0.8546339760851562 0.03116990730207581 0.19489280180802032 0.3855395915188041 0.012543255180366303 0.027241117088357584 1.0104941582478826e-06 5.9954661928345185 -0.20360160254826865 GYTS(ph)DSEVYTDHGRPGK ddPTM_A459_Selumetinib_30min_R1 1 GYTSDSEVYTDHGRPGK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.029)S(0.954)DS(0.018)EVYTDHGRPGK 186.29 2.8448e-07 46248000.0 1954.4 2467.4 2560.7 2909.6 2795.3 2268.9 2923.9 2209.6 1342.1 2212.6 True False 1999.9337173996003 2178.5156609368605 2212.971004918258 2401.492979956383 2542.4656085502993 2246.076925996372 2703.3478689546064 2150.9942302076743 2277.4456768943196 2496.6087625490977 0.8010601209929343 0.8725899282323049 0.8863907866199914 0.9619020072269556 1.0183676540309747 0.8996511426576399 1.0828079711594152 0.8615664025834218 0.9122156867578213 1.0 11.285754042430561 -5.276401381219135 1.4294014346959867 0.9612001420120865 0.8051231478949332 0.4197458320379329 0.06132836812262247 0.5836885554674056 1.9021241598541312 0.018625078713550663 0.09992220922795443 5.291741474456577e-06 5.276401381219135 -0.15607699411715326 GYTS(ph)DSEVYTDHGRPGK ddPTM_A459_Selumetinib_30min_R2 3 GYTSDSEVYTDHGRPGK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 GYT(0.109)S(0.83)DS(0.061)EVYTDHGRPGK;GYT(0.004)S(0.996)DSEVYTDHGRPGK;GY(0.001)T(0.195)S(0.796)DS(0.007)EVYT(0.001)DHGRPGK 156.13 2.628e-05 263271000.0 104831.0 71227.0 103266.0 110437.0 122600.0 89654.0 88616.0 94302.0 71662.0 91779.0 True False 99004.91269174259 76689.88186909752 96621.9779875195 95395.29008554878 107197.89194209379 102003.02470201896 92736.81958927278 94576.4032074634 85996.402403577 89129.10179952037 1.1108034378539575 0.8604359330535765 1.084067673035155 1.0703046273272567 1.202726043208826 1.1444412951838796 1.0404774390957885 1.061116978607007 0.9648521152721834 1.0 16.44360894672625 -4.395479091606429 22.766893066283878 1.0546952901192819 45.73091201460229 0.03773929845346624 0.0895082630709716 4952.177446138802 881338.5706316858 0.022776244298267235 47639.44904151389 4.022730223055621e-05 4.395479091606429 44.676216724483005 GYTSDDDT(ph)WEPEIHLEDCK ddPTM_A459_Selumetinib_30min_R2 1 GYTSDDDTWEPEIHLEDCK 19 0 Q99549-2;Q99549 Q99549-2 MPHOSPH8 M-phase phosphoprotein 8 1 GY(0.011)T(0.25)S(0.25)DDDT(0.49)WEPEIHLEDCK 115.46 0.0016672 0.0 7437.8 4232.0 5755.6 6036.4 5412.7 4542.9 6099.5 5140.4 4721.8 6811.8 True False 7024.4368518724705 4556.580791975248 5385.290962223457 5214.231906629181 4732.708235848051 5168.643238659759 6383.138835929961 5155.35771296097 5666.2919381151905 6615.125634818114 1.0618750481321146 0.6888124343386764 0.8140874806486617 0.7882287041057155 0.7154373925927983 0.7813371240381398 0.9649308551802687 0.7793287682740615 0.8565660353132488 1.0 12.691552841167228 -8.573371859499069 11.255022768432255 1.0000000005690126 0.8178353528011577 0.19577577931572154 0.105844319063114 13.46478656675642 3002.547007872926 0.09827357509828816 0.025377958462425933 2.670718658199139e-09 8.573371859499069 -0.1821646477678549 GYVLGETSNLPS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 3 GYVLGETSNLPSPGK 15 0 B1AKT1;Q9H040 B1AKT1 SPRTN SprT-like domain-containing protein Spartan 1 GYVLGETSNLPS(1)PGK;GYVLGETSNLPS(1)PGK;GYVLGETSNLPS(0.999)PGK 165.78 8.3986e-05 38705700.0 6616.5 8651.1 7936.0 7801.5 6498.9 7005.700000000001 6903.2 6767.5 4247.68 6165.5 True False 6770.651576532157 7638.225190212719 6858.334789327639 6439.11447729232 5911.075642473986 6935.229018666656 6382.486066201792 6588.003916061925 7208.002721727491 6956.9019820557105 0.9732279675631541 1.0979348580610133 0.9858317404812788 0.9255721144125724 0.8496706806737715 0.9968846817958688 0.9174322252440039 0.9469738014211926 1.036093758445851 1.0 12.764229278933593 -5.508819693189873 8.723259845068101 0.9476430181565026 1.0372774119358208 0.24853434444927525 0.05636554598751269 0.236133416640434 120.64260490681923 0.014806739745836616 0.02856974362609967 3.0987055272635788e-06 5.508819693189873 0.08963439377931814 GYVLGETSNLPS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 4 GYVLGETSNLPSPGK 15 0 B1AKT1;Q9H040 B1AKT1 SPRTN SprT-like domain-containing protein Spartan 1 GYVLGETSNLPS(1)PGK;GYVLGETSNLPS(1)PGK;GYVLGET(0.002)S(0.003)NLPS(0.995)PGK;GYVLGET(0.001)S(0.001)NLPS(0.999)PGK 177.39 1.9502e-05 6941500.0 144680.0 128814.0 135837.0 134959.0 131156.0 119879.0 129590.0 127242.0 105539.0 138147.0 True False 136639.26479992882 138693.61959770773 127097.39530814336 116577.35138273962 114679.0107304832 136391.24409678683 135616.19177771342 127612.25315395306 126649.74900604416 134158.3371609877 1.0184925342057873 1.0338054461071455 0.9473685944365029 0.8689534608859143 0.8548034595335686 1.0166438179173292 1.0108666717818389 0.9512062824751664 0.9440318931060292 1.0 17.03357718693364 -10.028850183386375 15.344345591740773 0.999999704380968 0.9594754180961392 0.03838157268294018 0.05875471031778256 0.0 0.0 0.063363288239577 0.015367854717543138 9.357284124983727e-11 10.028850183386375 -0.04052428628482874 GYYS(ph)PYSVS(ph)GSGSTAGSR ddPTM_A459_Selumetinib_30min_R1 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GY(0.004)Y(0.04)S(0.953)PY(0.002)S(0.028)VS(0.898)GS(0.045)GS(0.03)T(0.001)AGSR 110.26 0.0253 7376000.0 1648.4 1671.4 1932.0 2045.8 1944.2 1245.9 1500.3 1442.1 798.54 1349.9 True False 1686.8045127719495 1475.7117109872204 1669.6450117163567 1688.5394344221777 1768.3474532763887 1233.3673771866897 1387.1311631015396 1403.8508233990262 1355.0640569459715 1523.1728141394858 1.1074281900999574 0.9688406314032866 1.096162560293344 1.108567208361131 1.1609631138771432 0.8097356818198458 0.9106853472074324 0.9216622108582798 0.889632512061025 1.0 10.57286391917153 -6.758693247898858 24.999999995500563 0.9017184241585985 1.083303086375577 0.6778597884604604 0.06266002357729178 44.00072612378785 400570.90866819926 0.02139053409499988 0.020479418366849356 1.743037585915198e-07 6.758693247898858 0.18158466221697855 GYYS(ph)PYSVSGS(ph)GSTAGSR ddPTM_A459_Selumetinib_30min_R2 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GY(0.085)Y(0.027)S(0.888)PYS(0.031)VS(0.354)GS(0.564)GS(0.042)T(0.005)AGS(0.004)R 132.87 0.0084215 21327000.0 33805.0 33563.0 43831.0 37989.0 57222.0 27358.0 35735.0 34491.0 29963.0 33039.0 True False 31926.25343213705 36137.17417794546 41010.9611795845 32814.832665319744 50033.26078882944 31126.31616880265 37396.74830755914 34591.36309970758 35956.43723616954 32085.07822436883 0.9950498860834582 1.126292226100887 1.2781942089340583 1.0227443559852898 1.5593934488471604 0.9701181325206184 1.1655495444345234 1.0781137218308294 1.1206591732371214 1.0 14.969614880110992 GYYS(ph)PYSVSGSGS(ph)TAGSR ddPTM_A459_Selumetinib_30min_R1 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GY(0.01)Y(0.177)S(0.736)PY(0.002)S(0.072)VS(0.007)GS(0.098)GS(0.779)T(0.1)AGS(0.02)R 111.11 0.024207 3505800.0 2278.3 2265.9 2347.2 2327.8 2600.7 1919.3 2440.2 2026.6 1252.6 1901.4 True False 2331.379957199911 2000.607374611668 2028.4631322467033 1921.293428217787 2365.4671441908777 1899.99358458497 2256.1337493837095 1972.8479846754492 2125.5707137156865 2145.4632112043996 1.0866557604085616 0.9324827217561965 0.9454662851608553 0.8955145062306754 1.1025437918662675 0.8855866531117864 1.0515835170705083 0.9195440753178661 0.9907281106546935 1.0 11.067073447706896 GYYS(ph)PYSVSGSGS(ph)TAGSR ddPTM_A459_Selumetinib_30min_R2 4 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GYYS(1)PYSVSGSGS(0.63)T(0.37)AGSR;GYY(0.004)S(0.911)PY(0.001)S(0.087)VS(0.126)GS(0.392)GS(0.428)T(0.05)AGSR;GYYS(0.353)PYS(0.159)VS(0.459)GS(0.034)GS(0.755)T(0.238)AGS(0.003)R;GYY(0.014)S(0.49)PY(0.002)S(0.007)VS(0.485)GS(0.03)GS(0.957)T(0.015)AGSR 256.33 1.6772e-33 74833000.0 334134.0 298074.0 359429.0 375244.0 391395.0 271299.0 288071.0 288559.0 234569.0 300211.0 True False 315564.16992438026 320935.31734102726 336303.72945670545 324135.1198679945 342224.46098430484 308667.974642883 301466.87230185757 289398.65891648614 281489.35440546786 291543.1283881477 1.082392754955459 1.1008159208394996 1.1535299470648661 1.1117913210990014 1.1738381997763372 1.0587386379140997 1.0340386822648684 0.9926444177109656 0.9655153114454659 1.0 18.153349793571834 -7.250832814025884 1.8233068235958705 0.9861390773063125 1.1233838161279186 0.8139947414855697 0.028529656840875963 0.1481410072970829 0.961542475637791 0.015238539888028745 0.009581189873769679 5.6126399860038523e-08 7.250832814025884 0.13724473882160615 GYYS(ph)PYSVSGSGSTAGS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GY(0.004)Y(0.001)S(0.931)PYS(0.063)VSGSGS(0.002)T(0.017)AGS(0.982)R 113.23 0.021469 11569000.0 1554.2 1744.5 1713.5 1566.4 2062.9 1506.0 1671.6 1317.4 760.23 1646.1 True False 1590.4098360532432 1540.2531290039522 1480.816111581768 1292.8576449696457 1876.311059234577 1490.851007338594 1545.5098661871182 1282.4582724817117 1290.0547849976663 1857.392969371811 0.8562592096981695 0.8292553888178447 0.7972551506333067 0.696060374023545 1.0101852920597434 0.8026578284307896 0.8320855584533763 0.6904614659521684 0.6945513449606605 1.0 10.859063363794535 -10.904416353594197 5.503176041344984 1.0000780014201618 0.8024787029018975 0.29989778862434235 0.09120103133555421 8.977817628039143e-05 1.008953356895309e-05 0.09083117117716105 0.022021120392356885 1.2461882337093507e-11 10.904416353594197 -0.1975992985182643 GYYS(ph)PYSVSGSGSTAGS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GYY(0.001)S(0.994)PYS(0.004)VSGSGS(0.005)T(0.01)AGS(0.985)R;GYYS(0.984)PYS(0.015)VS(0.001)GSGST(0.001)AGS(0.999)R 136.81 0.014296 0.0 63959.0 50595.0 63149.0 66835.0 68093.0 51317.0 48470.0 56885.0 50210.0 51291.0 True False 60404.414828163084 54475.47381143375 59086.06209143258 57731.95770319425 59538.548580856404 58385.45094065522 50723.95104148294 57050.52593218128 60253.40298461676 49810.09555997764 1.2126942168867865 1.093663306584875 1.186226635929367 1.1590412958288283 1.1953108684396012 1.1721609903428465 1.0183467923767562 1.1453607002918764 1.2096624651535561 1.0 15.604150558353036 GYYS(ph)PYSVSGSGSTAGSR ddPTM_A459_Selumetinib_30min_R1 4 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GY(0.003)Y(0.001)S(0.942)PYS(0.054)VSGSGSTAGSR;GYYS(0.774)PYS(0.226)VSGSGSTAGSR;GY(0.004)Y(0.282)S(0.703)PYS(0.01)VSGSGSTAGSR;GY(0.007)Y(0.408)S(0.528)PY(0.005)S(0.053)VSGSGSTAGSR 265.43 2.3439e-43 459571000.0 19368.800000000003 19022.4 21485.2 22227.4 23006.4 16033.499999999998 18917.8 16862.800000000003 9159.439999999999 15820.7 True False 19820.055354875854 16795.248564726153 18567.627849755827 18345.801849973373 20925.475182109818 15872.217547253214 17490.815115191843 16415.543765906044 15542.90070097079 17851.440951667966 1.1102776189629637 0.9408343343374123 1.0401192766470173 1.0276930528826143 1.1722009018075723 0.8891280872074463 0.9797985026837608 0.9195640738666669 0.8706804533624231 1.0 14.12375291150252 -6.791053349672427 24.99986439127965 0.9298047224495569 1.0490013658033601 0.47385751313227276 0.06621775049571507 197.63584344779179 166841.1420751964 0.023092251991247113 0.020368178779576192 1.61788128140354e-07 6.791053349672427 0.1191966433538032 GYYS(ph)PYSVSGSGSTAGSR ddPTM_A459_Selumetinib_30min_R2 5 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYS(0.999)PYS(0.001)VSGSGSTAGSR;GYYS(0.996)PYS(0.004)VSGSGSTAGSR;GYYS(0.957)PYS(0.043)VSGSGSTAGSR;GYYS(0.653)PYS(0.347)VSGSGSTAGSR;GYYS(0.691)PYS(0.104)VS(0.066)GS(0.104)GS(0.031)T(0.004)AGSR 289.59 1.0410999999999993e-80 532941900.0 217172.0 201025.7 262720.0 249420.0 314795.0 187015.0 190794.6 208541.0 179219.0 220749.0 True False 205102.4496483973 216443.72479049567 245816.8812279083 215448.5657265011 275247.63779699354 212774.6186968575 199666.9269523275 209147.81978417913 215067.80779725182 214375.4027952175 0.9567443231550301 1.0096481311209662 1.1466655130333463 1.0050059984368112 1.283951583101744 0.9925327995773418 0.9313891628838581 0.9756148189443542 1.0032298714918135 1.0 17.709779856440008 -6.9729966126694025 24.99895319632153 0.9735882550921832 1.0821925248222986 0.2497344284244789 0.08670770442222443 301.8767938583079 279467.9176953374 0.030781054858837843 0.027145735179953386 1.0641513181645944e-07 6.9729966126694025 0.10860426973011539 GYYSPYS(ph)VSGSGSTAGSR ddPTM_A459_Selumetinib_30min_R1 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYS(0.001)PYS(0.964)VS(0.029)GS(0.006)GSTAGSR 185.63 1.7728e-10 3258800.0 821.0 866.26 1320.5 1127.9 1239.1 674.38 901.23 1021.3 415.88 712.98 True False 840.1277026120913 764.8378764866513 1141.1833529872927 930.9334383051983 1127.0236237808724 667.5963494880489 833.2494955155643 994.2118063500628 705.7179853265844 804.497928013313 1.0442882117630372 0.9507021085503587 1.4185037813651251 1.1571607656021123 1.400903078226725 0.8298297935168845 1.0357385227495273 1.2358164909202978 0.8772154169114356 1.0 9.651944895063076 -6.766665001603445 24.999984701017958 1.0129597748864425 1.1911689095607934 0.25841533220257684 0.166895045098072 217.106042645392 1038653.0686630593 0.059432736991233845 0.05396725554502639 1.7113348653210874e-07 6.766665001603445 0.17820913467435084 GYYSPYS(ph)VSGSGSTAGSR ddPTM_A459_Selumetinib_30min_R2 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYS(0.063)PYS(0.724)VS(0.164)GS(0.049)GSTAGSR 209.23 1.3984000000000003e-11 133810000.0 17821.0 14406.0 19451.0 19269.0 21505.0 11313.0 13473.0 15266.0 12016.0 16841.0 True False 16830.580163115344 15510.893877409122 18199.543836647532 16644.528959120955 18803.34964286073 12871.263060810898 14099.521196243018 15310.421532577659 14419.535755091722 16354.756571827098 1.0290938962740606 0.9484026135936732 1.112798209910277 1.0177179272599521 1.1497174880151753 0.787004258014032 0.8621052312408627 0.9361448741433166 0.8816722946479674 1.0 13.997422665706218 -6.761861561638204 24.999999964132083 0.8874393860019635 1.0473393925192886 0.5470052726484067 0.07181185648133907 8.807015360931146 521494.47703870316 0.024283067345397064 0.02274262177650541 1.7303678539380203e-07 6.761861561638204 0.15990000651732517 GYYSPYSVS(ph)GSGS(ph)TAGSR ddPTM_A459_Selumetinib_30min_R2 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GY(0.001)Y(0.001)S(0.307)PYS(0.134)VS(0.557)GSGS(0.677)T(0.276)AGS(0.047)R 190.18 4.1278000000000006e-09 12591000.0 59561.0 51817.0 59828.0 76139.0 70610.0 42946.0 48292.0 52795.0 45593.0 48218.0 True False 56250.838061574155 55791.19728208442 55978.731615801174 65768.73685289908 61739.34053859093 48861.42167502738 50537.67368878263 52948.62470931724 54712.87397485824 46825.82105459055 1.201278200674703 1.1914622322808144 1.1954671665135346 1.4045399604680602 1.3184892255624066 1.0434717549973909 1.0792693550394923 1.1307569951114917 1.1684338414712 1.0 15.515016670782343 -6.762911873792213 24.999956092224835 1.0922388763439403 1.2625099908112352 0.5891260155639344 0.07412277057411684 32.62132521927623 553836.8329541556 0.027759339489557257 0.0258010193645527 1.726188131256697e-07 6.762911873792213 0.17027111446729482 GYYSPYSVS(ph)GSGSTAGS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GYYS(0.002)PYS(0.015)VS(0.983)GS(0.001)GS(0.001)T(0.002)AGS(0.997)R;GYYSPYS(0.019)VS(0.977)GS(0.004)GS(0.005)T(0.003)AGS(0.992)R 152.59 0.0016504999999999998 23811000.0 3563.3 4051.8 4097.2 4207.8 4804.5 3204.2 3842.8 4083.3 2229.66 3146.13 True False 3646.3179570251705 3577.413372369285 3540.822744308621 3472.9867201885054 4369.933823303369 3171.9686571808247 3552.934502143973 3974.997619572319 3783.570172076737 3549.966431401334 1.0271415314723982 1.007731605776654 0.9974242891392346 0.978315369257607 1.2309789142367626 0.8935207468789229 1.0008360841714967 1.1197282274027605 1.065804492856342 1.0 11.793589667172421 GYYSPYSVS(ph)GSGSTAGSR ddPTM_A459_Selumetinib_30min_R1 2 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYSPYS(0.037)VS(0.834)GS(0.128)GSTAGSR;GYYS(0.008)PYS(0.196)VS(0.788)GS(0.007)GS(0.001)TAGSR 297.73 1.775099999999999e-95 187779000.0 9271.7 7781.0 11563.2 11863.5 12122.8 7404.799999999999 8942.0 8383.4 4487.3 7059.799999999999 True False 9487.71257041233 6869.9969027112365 9992.980952111058 9791.76243047586 11026.294880454174 7330.314435020467 8267.497740754494 8161.044998878992 7614.620360575128 7965.9940982753915 1.191026813899647 0.8624155149949917 1.2544549781017917 1.229195290591006 1.3841706062575827 0.9202008367803652 1.0378488408049884 1.0244854437747861 0.9558907860882881 1.0 12.959638695522612 -6.797039164056538 24.99999290082737 0.9923507218346206 1.172770240645075 0.37327390832878293 0.12684480638531184 228.1298936733069 160202.91988314703 0.04734601023359674 0.04175676034195854 1.595735239621718e-07 6.797039164056538 0.18041951881045448 GYYSPYSVS(ph)GSGSTAGSR ddPTM_A459_Selumetinib_30min_R2 4 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYSPYSVS(0.951)GS(0.045)GS(0.004)TAGSR;GYYSPYS(0.004)VS(0.877)GS(0.1)GS(0.019)TAGSR;GYYS(0.084)PYS(0.262)VS(0.506)GS(0.148)GSTAGSR;GYYS(0.001)PYS(0.014)VS(0.921)GS(0.045)GS(0.014)T(0.004)AGSR 265.93 1.3025999999999993e-43 211528400.0 130536.1 124720.0 144633.0 161037.0 188559.0 85498.2 113597.0 123690.0 102316.0 121922.0 True False 123281.42613941095 134285.62296199292 135327.470244504 139103.48279567983 164870.53268115237 97274.80097461522 118879.48558818515 124049.91742201819 122782.05894789993 118401.79506860046 1.0412124754357255 1.1341519179180481 1.1429511703441406 1.1748426847336653 1.3924664958468622 0.8215652551403927 1.0040344871402322 1.047703012865179 1.0369949110717587 1.0 16.853331428012936 -6.771991458555694 24.999998417838942 0.9864144556802282 1.1727122465863067 0.48219101571660594 0.10096851556535195 206.3017285000887 488767.2686847926 0.036643159595260245 0.03264860412019246 1.6904741785521248e-07 6.771991458555694 0.18629779090607845 GYYSPYSVSGSGS(ph)TAGS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GY(0.005)YS(0.001)PYS(0.065)VS(0.029)GS(0.042)GS(0.594)T(0.285)AGS(0.978)R;GYYSPYS(0.001)VS(0.005)GS(0.012)GS(0.911)T(0.071)AGS(1)R 135.57 0.0065262 111770000.0 18105.2 24979.7 18516.0 18360.4 21589.2 19192.4 23473.3 23322.9 12965.9 18379.3 True False 18527.015933413426 22055.065111252527 16001.628901107675 15154.100807393172 19636.460671882844 18999.34188130494 21702.690082537752 22704.300928543904 22002.18530813208 20738.46218454246 0.8933649837943457 1.0634860441914253 0.7715918740124612 0.7307244226955446 0.9468619465197858 0.9161403440736419 1.0464946672233966 1.094791924613711 1.0609362021322655 1.0 14.340021297760856 -7.153642835911687 2.141579414834504 1.0629502258451005 0.8767704178838699 0.4566897947838624 0.08788995987803394 0.31454503652395754 2.828152354336617 0.044316095867659305 0.0310779726725047 7.020324130294738e-08 7.153642835911687 -0.18617980796123057 GYYSPYSVSGSGS(ph)TAGS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 GYYS(0.004)PYS(0.013)VS(0.004)GS(0.278)GS(0.614)T(0.086)AGS(1)R;GYYS(0.002)PYS(0.011)VS(0.034)GS(0.157)GS(0.733)T(0.063)AGS(1)R;GYYSPYS(0.004)VS(0.001)GS(0.007)GS(0.886)T(0.101)AGS(1)R 169.06 1.8971e-06 115693700.0 992876.0 650161.0 901899.0 1006894.0 917893.0 801748.0 753020.0 804304.0 711188.0 797894.0 True False 937695.9267175423 700026.2581028881 843871.8002533854 869753.3002109663 802579.0752724654 912181.5094562909 788036.9220808235 806644.3914803041 853445.472253009 774856.727042422 1.210153947164745 0.9034267028626608 1.0890681732536407 1.1224698319788204 1.035777386015422 1.1772260311116207 1.0170098478575638 1.0410239252348152 1.1014235825383554 1.0 19.563570051541348 -11.143958261758913 2.5545261443631504 0.9921564972777992 1.0729041237761838 0.07173788139405268 0.0821544148027635 20501933.323267445 17552381.441760108 1066507.3101926972 0.020249732723930672 7.178632788180954e-12 11.143958261758913 0.08074762649838463 GYYSPYSVSGSGS(ph)TAGSR ddPTM_A459_Selumetinib_30min_R1 6 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYSPYS(0.001)VS(0.005)GS(0.016)GS(0.953)T(0.003)AGS(0.022)R;GYYSPYSVSGS(0.001)GS(0.499)T(0.499)AGS(0.001)R;GYYSPYSVSGS(0.001)GS(0.998)TAGSR;GYYSPYSVS(0.009)GS(0.012)GS(0.433)T(0.433)AGS(0.113)R;GYYSPYSVSGS(0.016)GS(0.511)T(0.114)AGS(0.358)R;GYYSPYS(0.001)VS(0.011)GS(0.001)GS(0.494)T(0.494)AGSR 284.15 2.2585999999999997e-67 1244934200.0 10409.93 11801.0 12423.0 12785.0 13603.7 10596.29 11753.2 11169.6 6638.5 8945.310000000001 True False 10652.461114802301 10419.333433863942 10736.0248346544 10552.339754173207 12373.247736928299 10489.70094326154 10866.646661444398 10873.3459240259 11265.049643143533 10093.527673198083 1.0553754306423895 1.0322786810731186 1.0636543716189906 1.0454560680695841 1.2258595941420645 1.0392502287496015 1.0765955187599299 1.0772592374119618 1.1160666525991958 1.0 13.301142861938592 GYYSPYSVSGSGS(ph)TAGSR ddPTM_A459_Selumetinib_30min_R2 2 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYSPYSVSGS(0.002)GS(0.921)T(0.076)AGS(0.001)R;GYYS(0.002)PY(0.001)S(0.001)VS(0.063)GS(0.187)GS(0.563)T(0.105)AGS(0.079)R 268.18 1.1737999999999996e-111 83306000.0 33540.0 27193.0 29814.0 32964.0 29315.0 26250.0 22596.6 23233.2 26737.0 27359.0 True False 31675.981071258 29278.615660723728 27895.799699028812 28474.246333928226 25632.18762057485 29865.699226225246 23647.386674313442 23300.804765536694 32085.147094198328 26569.07458278118 1.1922124337663793 1.1019810106483174 1.049934938912304 1.0717063646763876 0.9647376893279712 1.1240775109864207 0.8900342614732536 0.8769897006739339 1.2076125193683633 1.0 14.697460358296832 -3.298614426921103 0.5615559767354201 1.0008697646337097 2.107532796393453 0.25193798896251185 0.0943402156304331 24.601175890775455 1.5908125355342415 0.046159756747695985 25.629473892855977 0.0005027887747555795 3.298614426921103 1.1066630317597432 GYYSPYSVSGSGSTAGS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYSPYSVS(0.109)GS(0.243)GS(0.277)T(0.048)AGS(0.323)R;GYYSPYSVSGSGST(0.002)AGS(0.998)R;GYYSPYSVSGSGSTAGS(0.999)R 292.38 6.457899999999998e-81 1203321000.0 4740.16 5263.200000000001 6208.200000000001 5223.08 5250.7699999999995 4452.91 5148.3 5230.9 3036.58 4085.63 True False 4850.596505254236 4646.982097204703 5365.160539201597 4310.967127354476 4775.8387805987395 4408.117768318793 4759.959586079892 5092.159539642164 5152.854476971723 4610.060407906297 1.0521763439228295 1.0080089382852955 1.1637939776234378 0.9351216135825742 1.0359601302421397 0.9561952291902358 1.0325156646356557 1.1045754478420853 1.1177412053287912 1.0 12.170569939788686 -10.44842754565739 4.6692818546433115 0.9999995885658249 1.0427775485679727 0.038422893185006135 0.06679729166181948 47249214.97436558 498.2614424825541 209.03004332899621 0.01634252801743946 3.5610039412450196e-11 10.44842754565739 0.04277796000214773 GYYSPYSVSGSGSTAGS(ph)R ddPTM_A459_Selumetinib_30min_R2 7 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 GYYSPYSVSGSGS(0.003)T(0.003)AGS(0.994)R;GYYSPYSVS(0.007)GS(0.002)GS(0.019)T(0.087)AGS(0.885)R;GYYSPYSVS(0.006)GSGS(0.012)T(0.084)AGS(0.898)R;GYYSPYSVSGSGST(0.003)AGS(0.997)R;GYYSPYSVSGSGSTAGS(0.999)R;GYYSPYSVSGS(0.002)GS(0.001)T(0.004)AGS(0.993)R;GYYSPYSVSGSGST(0.003)AGS(0.997)R 333.65 1.8252999999999986e-144 2089093800.0 242574.3 228275.0 247787.3 256742.9 256887.6 185804.69999999998 209600.30000000002 195022.7 202677.3 229250.9 True False 229092.9915078611 245782.9584801864 231844.93488841358 221774.0741137935 224615.08308371808 211397.61085786705 219347.1292651154 195590.18376925416 243218.4232769188 222631.8308516289 1.0290217289752164 1.103988398873593 1.0413826899843657 0.9961471963171022 1.0089082150764457 0.94953902166286 0.9852460379364953 0.878536474416381 1.0924692230510813 1.0 17.764300351612484 -5.788394631356998 1.8939198603035554 0.9777266384638832 1.0687442548061834 0.2725601793252367 0.053129589145666074 0.38637340237080553 2.8293520644223418 0.015754381959239065 0.030967883952015773 1.627816208938401e-06 5.788394631356998 0.09101761634230021 HAALCAMEVLPLALPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 HAALCAMEVLPLALPSPPR 19 0 Q9ULI0-2;Q9ULI0;H7BYF1 Q9ULI0-2 ATAD2B ATPase family AAA domain-containing protein 2B 1 HAALCAMEVLPLALPS(1)PPR 104.3 0.00060922 21723000.0 2389.6 3031.4 2655.7 3251.5 3038.3 2504.4 2618.3 2734.5 1571.9 2610.0 True False 2445.27303064781 2676.4822787403727 2295.070526715903 2683.68656321425 2763.4863014554344 2479.208009813263 2420.7995229945777 2661.972177092182 2667.3994929663804 2945.018923552899 0.830308087697382 0.9088166657725373 0.7793058673956185 0.9112629266152982 0.9383594378135737 0.8418309267847836 0.8219979517395093 0.9038896680095873 0.905732547805976 1.0 11.524061188948115 -8.676499399592807 1.4094826887644116 0.9992505523085554 0.8654194043519969 0.4379567171884202 0.046277484644760385 0.6194165247272563 2.485831731219146 0.0446148042786459 0.0132150943115067 2.1062048107934843e-09 8.676499399592807 -0.13383114795655848 HAASYS(ph)SDSENQGSYSGVIPPPPGR ddPTM_A459_Selumetinib_30min_R2 2 HAASYSSDSENQGSYSGVIPPPPGR 25 0 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;F2Z3L2;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 HAAS(0.029)YS(0.871)S(0.099)DS(0.002)ENQGSYSGVIPPPPGR;HAAS(0.019)YS(0.478)S(0.478)DS(0.025)ENQGSYSGVIPPPPGR 183.44 2.8633e-26 20444000.0 22815.7 17084.0 27504.2 30847.5 35293.8 21054.5 18924.8 18933.2 16638.1 20709.8 True False 21547.69473248364 18394.28786628193 25734.609716308718 26646.017285094375 30859.8773134247 23954.56626127845 19804.840698779775 18988.29247744001 19966.184907356146 20111.854263477515 1.071392744308692 0.9145993017503796 1.2795741943616779 1.3248911281881497 1.5344123375767122 1.1910670168677175 0.9847346962306073 0.9441343512478678 0.9927570399917873 1.0 14.295758480257817 -7.239157031789633 5.017411963215974 0.9742199643545363 1.2289761997906214 0.37254270919629606 0.15205021364984303 0.23389906810254887 17.140933759862794 0.07004941957042608 0.05146194729963234 5.765579544162804e-08 7.239157031789633 0.25475623543608517 HADGEKEDQFNGS(ph)PPRPQPR ddPTM_A459_Selumetinib_30min_R1 1 HADGEKEDQFNGSPPRPQPR 20 2 Q69YN4-3;Q69YN4;Q69YN4-4;Q69YN4-2 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 HADGEKEDQFNGS(1)PPRPQPR 81.60600000000002 0.0041098 8306600.0 835.49 898.9 1073.2 1007.4 814.61 812.23 770.19 642.32 388.58 733.02 True False 854.955291419459 793.6563701127276 927.4653346656274 831.4765012400541 740.9286693310762 804.0597036458338 712.0939482164739 625.2835870505944 659.3918792396946 827.1102572194436 1.0336654441859106 0.9595532919405686 1.121332164086025 1.0052789141260183 0.8958039908994838 0.9721312202666903 0.8609419868765401 0.7559857728673992 0.7972236754219685 1.0 9.691935849208834 -6.756441660666536 1.1498076395230283 0.83513107226653 1.0310693060945793 0.47218614010397086 0.0773586227492045 0.3866973154625783 1.0835105261032407 0.04035228776465985 0.03658344407953398 1.7520977799377728e-07 6.756441660666536 0.1959382338280492 HADGEKEDQFNGS(ph)PPRPQPR ddPTM_A459_Selumetinib_30min_R2 1 HADGEKEDQFNGSPPRPQPR 20 2 Q69YN4-3;Q69YN4;Q69YN4-4;Q69YN4-2 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 HADGEKEDQFNGS(1)PPRPQPR 50.966 0.028036 8400600.0 20760.0 21049.0 22981.0 21277.0 21914.0 16386.0 23222.0 19144.0 17189.0 25698.0 True False 19606.242308864526 22663.390616797493 21502.427479820934 18379.035895127756 19160.967406354353 18643.02276270196 24301.86901352003 19199.7058705402 20627.280300788243 24956.031968577452 0.785631398996085 0.9081327770910591 0.861612435298007 0.7364566577839418 0.7677890231299688 0.7470347363785915 0.9737873811076581 0.7693412917051423 0.8265448740713424 1.0 14.607100942181331 -8.596438771260258 19.345081077445748 1.0000000004610643 0.8200017708959666 0.3609837282374374 0.07206003558162102 7800.89986179452 2051507.749340387 0.07101314225412887 0.018335514507972217 2.5325686627439052e-09 8.596438771260258 -0.1799982295650977 HALEHPEPGAEHNGLEGPNDSGRET(ph)PQPVPAQ ddPTM_A459_Selumetinib_30min_R2 1 HALEHPEPGAEHNGLEGPNDSGRETPQPVPAQ 32 1 Q5T457;A0A0A0MRN9;Q9GZV1-2;Q9GZV1 Q5T457 ANKRD2 Ankyrin repeat domain-containing protein 2 1 HALEHPEPGAEHNGLEGPNDS(0.324)GRET(0.676)PQPVPAQ 45.666 0.012113 6238300.0 5846.7 5609.5 7610.7 8015.5 11276.0 8916.8 6240.0 6751.1 7064.4 8477.0 True False 5521.763820194518 6039.730612614641 7121.03584790362 6923.775072491259 9859.408071280985 10145.008261348761 6530.172364325426 6770.744583295229 8477.477395828055 8232.246984108922 0.6707480753254158 0.733667323669152 0.8650172743419479 0.841055314042027 1.1976569811757403 1.2323498409282578 0.793243008492203 0.8224661621991058 1.0297890007664385 1.0 13.007070551321066 -5.558962323257305 1.648567127363152 0.9979461435711119 0.6912352946652823 0.4281775880427646 0.1362761069030946 0.44419752513367927 2.339339566048831 0.046758891544243474 0.13234867993507213 2.7608173575211053e-06 5.558962323257305 -0.30671084890582956 HALT(ph)SPSLGGQGR ddPTM_A459_Selumetinib_30min_R1 1 HALTSPSLGGQGR 13 0 M0QZ22;Q5PRF9;M0QX45 M0QZ22 SAMD4B Protein Smaug homolog 2 1 HALT(0.875)S(0.122)PS(0.003)LGGQGR 106.54 0.016191 10604000.0 2629.9 3234.6 3820.2 3744.1 3850.5 2794.9 3418.5 2901.1 2057.8 2736.2 True False 2691.171553105406 2855.891528275257 3301.437822856532 3090.26322046147 3502.2229548609876 2766.7858435661587 3160.639792749859 2824.153403899115 3491.9363042345053 3087.4179228449966 0.8716576830083123 0.9250097005473128 1.0693200290209885 1.0009215783828358 1.1343533795495222 0.8961487925212983 1.023716215858911 0.9147298728177077 1.1310215822731096 1.0 11.592185068686224 -5.065507954747829 4.657591324386645 1.016888655061393 0.881563024526902 0.3130409802383187 0.07442307508403502 0.22673403312175433 9.547879973448328 0.0182477522087514 0.05641682045623734 8.599873148009021e-06 5.065507954747829 -0.13532563053449087 HALTS(ph)PSLGGQGR ddPTM_A459_Selumetinib_30min_R2 1 HALTSPSLGGQGR 13 0 M0QZ22;Q5PRF9;M0QX45 M0QZ22 SAMD4B Protein Smaug homolog 2 1 HALT(0.006)S(0.994)PSLGGQGR 110.25 0.0037419 8614100.0 31504.0 26326.0 28665.0 35083.0 36696.0 25960.0 27845.0 28750.0 18801.0 30116.0 True False 29753.133800504223 28345.119548568146 26820.725108092214 30304.634878449353 32085.920413597658 29535.754358583123 29139.84767382074 28833.65774018129 22561.7253438315 29246.472829234903 1.017323831636985 0.9691807868275397 0.9170584523027372 1.0361808432556252 1.0970868385032888 1.009891159560925 0.9963542559119273 0.9858849615314651 0.7714340623419963 1.0 14.835975023438403 -8.031110979768448 23.423102589667113 0.8833643768674261 1.005030937083754 0.33487327508910325 0.06697110026093979 345.8201418350149 260360.47511663486 0.04459288422086101 0.016912911792328525 9.308699702242044e-09 8.031110979768448 0.12166656021632793 HANS(ph)VDTSFSK ddPTM_A459_Selumetinib_30min_R2 1 HANSVDTSFSK 11 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 HANS(1)VDTSFSK 98.676 0.011914 4308700.0 48923.0 41647.0 51363.0 53270.0 56239.0 44058.0 55198.0 52826.0 40389.0 44329.0 True False 46204.055514286076 44841.19098378853 48058.36049980603 46014.53410412438 49173.754036960956 50126.58958129643 57764.81637276204 52979.71491418492 48467.92856294936 43049.10658942602 1.07328721023063 1.041628840557697 1.1163613906823893 1.0688847632305278 1.1422711859260586 1.1644048750969627 1.341835428170084 1.2306809388513098 1.1258753642718882 1.0 15.39369567681433 -6.53190897160111 2.2923570659340418 1.1981300767792793 1.0750267544967016 0.20679365563278174 0.08364557925430176 0.3839209603503569 4.060918622912744 0.02986477874218699 0.031920527319540294 2.938265449725546e-07 6.53190897160111 -0.1231033222825777 HAPHCLS(ph)EEEGEQDRPR ddPTM_A459_Selumetinib_30min_R1 2 HAPHCLSEEEGEQDRPR 17 1 E9PH18;A0A0J9YX62;O75190-4;O75190-3;O75190 E9PH18 DNAJB6 DnaJ homolog subfamily B member 6 1 HAPHCLS(1)EEEGEQDRPR;HAPHCLS(1)EEEGEQDRPR 152.66 8.838e-05 101222000.0 3758.7000000000003 4499.6 5077.5 4993.299999999999 4680.8 3771.2 3709.9 3869.8 2514.5 3112.0 True False 3846.270396842958 3972.784740192713 4388.003388711078 4121.313890849674 4257.42246646236 3733.2651519756323 3430.059256142374 3767.160333118056 4266.922848186248 3511.4555134469842 1.0953493165765058 1.1313783486588642 1.2496252257525082 1.1736768058337235 1.2124381044153125 1.0631674351787277 0.9768197953831662 1.0728201791797902 1.2151436439522674 1.0 11.777853442477062 -6.773457865307144 24.895409141003153 1.0645932892760728 1.1745602072158883 0.36424855347988483 0.07058393546571641 246.41773428278213 510433.17973296356 0.025735117574003867 0.0228726754669795 1.6847758736366697e-07 6.773457865307144 0.1099669179398155 HAPHCLS(ph)EEEGEQDRPR ddPTM_A459_Selumetinib_30min_R2 2 HAPHCLSEEEGEQDRPR 17 1 E9PH18;A0A0J9YX62;O75190-4;O75190-3;O75190 E9PH18 DNAJB6 DnaJ homolog subfamily B member 6 1 HAPHCLS(1)EEEGEQDRPR;HAPHCLS(1)EEEGEQDRPR 83.948 0.0069906000000000005 86369500.0 58137.8 56804.9 44905.3 49806.1 70101.9 46228.5 51586.7 50156.8 43514.1 55645.0 True False 54906.733820053196 61161.6531734581 42016.141887193895 43022.42325968521 61295.07260306254 52596.056254459196 53985.58376710683 50302.7479840948 52218.13588553901 54038.384266927125 1.0160691250285498 1.1318186878302097 0.7775240221774885 0.7961456258050268 1.1342876630117287 0.97330919434335 0.999022907502943 0.9308706887981728 0.9663156401494752 1.0 15.721696918666423 -5.209187649034765 24.999986565671012 0.9487874851151288 1.073943919097642 0.20419122509548038 0.10005797067367311 575.123055884377 275166.95037353365 0.02665924972343069 0.07053364487903795 6.177494266093482e-06 5.209187649034765 0.1251564339825133 HAPS(ph)PEPAVQGTGVAGVPEESGDAAAIPAK ddPTM_A459_Selumetinib_30min_R1 4 HAPSPEPAVQGTGVAGVPEESGDAAAIPAK 30 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK 135.78 4.0291e-18 421948000.0 16713.4 20111.0 20921.6 22114.6 20001.2 16577.1 18437.8 16857.5 9343.640000000001 14836.4 True False 17102.789701384805 17756.394770649753 18080.56163412262 18252.700252455128 18192.09499149867 16410.34942480253 17047.02190164205 16410.384339122866 15855.474647535084 16740.796458774035 1.0216234181869552 1.0606660689278873 1.080029954288489 1.0903125366468862 1.0866923229309078 0.9802609729599625 1.01829216690031 0.9802630585429526 0.947115908528059 1.0 14.031080546612715 -6.766281367940745 24.999933114368105 0.9860219581766472 1.069387862616486 0.7391736982800876 0.02454555485684113 66.24876972258976 342050.439196421 0.009049494175053213 0.008237820781284367 1.712847239403544e-07 6.766281367940745 0.08336590443983893 HAPS(ph)PEPAVQGTGVAGVPEESGDAAAIPAK ddPTM_A459_Selumetinib_30min_R2 6 HAPSPEPAVQGTGVAGVPEESGDAAAIPAK 30 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK;HAPS(0.995)PEPAVQGT(0.005)GVAGVPEESGDAAAIPAK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAK 136.62 3.6733e-18 506911500.0 440620.0 442892.0 489411.0 489817.0 509273.0 380839.0 409161.0 421227.0 348280.0 437274.0 True False 416132.1043416129 476860.39227776567 457922.8290904061 423103.079618546 445293.57278161374 433296.1153377672 428187.79723714007 422452.70083211665 417945.7317562702 424648.7634457063 0.9799442272362056 1.1229525041081039 1.0783566761732821 0.996360088712803 1.0486162002884227 1.0203635395565365 1.008334025896407 0.9948285199378182 0.984215115487336 1.0 18.695910523357604 -6.770953830729725 0.7801965712927607 0.9908295215669435 1.0594057488327084 0.2724980321985875 0.03749229607504132 0.8136121207980007 1.0831514688770874 0.025845765998095845 0.024800411657224176 1.6945179328259864e-07 6.770953830729725 0.06857622726576496 HAPS(ph)PEPAVQGTGVAGVPEESGDAAAIPAKK ddPTM_A459_Selumetinib_30min_R1 2 HAPSPEPAVQGTGVAGVPEESGDAAAIPAKK 31 1 P13051 P13051 UNG Uracil-DNA glycosylase 1 HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAKK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAKK 117.94 4.5424e-16 25348000.0 5508.1 5904.700000000001 6730.6 6446.4 5881.400000000001 5691.200000000001 5559.6 6061.700000000001 3435.42 4951.0 True False 5636.42801310312 5213.374978979444 5816.621488539391 5320.657253914912 5349.428408445509 5633.951695196152 5140.2348959403635 5900.924024823438 5829.656826850667 5586.509076823911 1.0089356225135842 0.933208002938285 1.0411907344194822 0.9524118158132229 0.9575619290834145 1.0084923550145226 0.9201157333235254 1.0562811128874565 1.0435240946865145 1.0 12.44773133145303 -7.784748343485597 24.99971979794195 1.0374269737544828 0.975331267710595 0.3386806271522027 0.03744862956488779 251.72335404795632 269978.6339413509 0.01913099142363539 0.009199209901724051 1.6415407057204985e-08 7.784748343485597 -0.06209570604388781 HAPS(ph)PEPAVQGTGVAGVPEESGDAAAIPAKK ddPTM_A459_Selumetinib_30min_R2 5 HAPSPEPAVQGTGVAGVPEESGDAAAIPAKK 31 1 P13051 P13051 UNG Uracil-DNA glycosylase 1 HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAKK;HAPS(0.999)PEPAVQGT(0.001)GVAGVPEESGDAAAIPAKK;HAPS(1)PEPAVQGTGVAGVPEESGDAAAIPAKK;HAPS(0.984)PEPAVQGT(0.016)GVAGVPEESGDAAAIPAKK;HAPS(0.999)PEPAVQGT(0.001)GVAGVPEESGDAAAIPAKK 152.88 1.6692e-20 65679400.0 196403.0 215010.0 216750.0 210885.0 234595.0 158534.0 174974.0 191802.0 139932.0 205785.0 True False 185487.70752350267 231500.5756338836 202804.54097955607 182162.0992030838 205123.07879409022 180370.61947163398 183110.63770440352 192360.1120654698 167922.31002675532 199843.4523563594 0.928165047873284 1.1584096096432193 1.0148170409802393 0.9115239806718994 1.0264188112018613 0.9025595652240754 0.9162703883732051 0.962553988120935 0.8402692609979409 1.0 17.608510779705774 -5.608353652436755 5.21895973084472 0.9374542062423722 1.0532537453621078 0.27985179987520903 0.07146926030754792 0.2209024372681435 10.06063705385655 0.018516137431904583 0.0328519866008806 2.4640320222373026e-06 5.608353652436755 0.11579953911973562 HAPSLHGS(ph)TELLPLSR ddPTM_A459_Selumetinib_30min_R2 1 HAPSLHGSTELLPLSR 16 0 H3BU67;H3BNR2;H3BT64;B4DHR0;Q9H5N1-2;Q9H5N1 H3BU67 RABEP2 Rab GTPase-binding effector protein 2 1 HAPSLHGS(0.928)T(0.072)ELLPLSR 117.03 0.0012398 3373700.0 19364.0 23160.0 30437.0 28748.0 28807.0 19537.0 20413.0 21490.0 21033.0 30928.0 True False 18287.826400233756 24936.29752886265 28478.71655729992 24832.47280693389 25188.007122152496 22228.04441077189 21362.244947592128 21552.532342138984 25240.187711122173 30035.028279405527 0.6088832755577389 0.8302405210639011 0.9481834440897549 0.8267837331773402 0.8386210556499943 0.7400707002501228 0.7112443760287661 0.7175798917731389 0.8403583800994424 1.0 14.874358401780368 -8.545713784946022 20.11407457467654 1.0000000050756357 0.784934450998405 0.369933322900585 0.08735566618996665 424.35290547898313 373789.5300831906 0.08976071389732157 0.023176116674314448 2.8463363233472083e-09 8.545713784946022 -0.21506555407723071 HAPTYTIPLS(ph)PVLS(ph)PTLPAEAPTAQVPPSLPR ddPTM_A459_Selumetinib_30min_R1 2 HAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPR 32 0 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 2 HAPT(0.023)Y(0.013)T(0.056)IPLS(0.87)PVLS(0.9)PT(0.133)LPAEAPT(0.004)AQVPPS(0.001)LPR;HAPT(0.001)YT(0.004)IPLS(0.991)PVLS(0.975)PT(0.028)LPAEAPTAQVPPSLPR 90.435 5.9604e-07 30224000.0 2939.5 3662.8999999999996 3631.1 3926.6 4222.7 3177.2 3578.2 3403.5 1921.8 2668.8 True False 3007.984630728674 3234.04596516399 3138.0165642045854 3240.8930214107545 3840.757530578237 3145.240252666787 3308.2934931746536 3313.228123873925 3261.1542372815015 3011.3664763134016 0.9988769730913429 1.0739463265604254 1.0420573480137272 1.0762200638490025 1.2754201658245858 1.0444561555049512 1.0986020861946895 1.1002407544664146 1.0829483103211992 1.0 11.55620257604817 -6.00075047578561 24.938391826800864 1.1090882497643824 1.044738781561531 0.12991484536940623 0.06897751128143066 52.104436948450775 1731614.0437519222 0.01932040867325859 0.028252321795979987 9.982734578351268e-07 6.00075047578561 -0.06434946820285137 HAPTYTIPLS(ph)PVLSPTLPAEAPTAQVPPSLPR ddPTM_A459_Selumetinib_30min_R1 1 HAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPR 32 0 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 HAPT(0.001)YT(0.003)IPLS(0.986)PVLS(0.01)PT(0.001)LPAEAPTAQVPPSLPR 87.54299999999998 1.6462e-07 53981000.0 1633.0 1795.4 2098.5 2076.0 1924.3 1915.7 1736.9 1859.3 1029.2 1305.4 True False 1671.045722735134 1585.1937333411845 1813.5352262353904 1713.4655713463897 1750.2474047627577 1896.4297973164316 1605.8842346137876 1809.9853241424378 1746.4772302061187 1472.9608056727805 1.1344807793252023 1.0761954610307103 1.2312175716088054 1.1632798135207392 1.1882511727549503 1.2874950847386806 1.090242339394967 1.2288075264268286 1.1856915835641728 1.0 10.52450332656754 -5.25180692704723 24.919798519858855 1.1815368295350903 1.1053381191231668 0.09651057401352636 0.07701584709897995 1229.6016864030244 3181043.834909392 0.018158526820999162 0.04671688198018808 5.600065065217549e-06 5.25180692704723 -0.0761987104119235 HAPTYTIPLS(ph)PVLSPTLPAEAPTAQVPPSLPR ddPTM_A459_Selumetinib_30min_R2 2 HAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPR 32 0 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 HAPT(0.106)YT(0.1)IPLS(0.669)PVLS(0.11)PT(0.015)LPAEAPTAQVPPSLPR;HAPT(0.002)Y(0.001)T(0.004)IPLS(0.857)PVLS(0.092)PT(0.043)LPAEAPTAQVPPS(0.001)LPR 64.016 0.00019614 35357000.0 54379.0 53497.0 63373.0 58973.0 70599.0 48007.0 50274.0 51810.0 47588.0 63585.0 True False 51356.83287638458 57600.047880033 59295.650175305294 50940.77566590064 61729.722456932046 54619.52848584358 52611.840616041125 51960.75852239275 57106.92971981566 61749.13583632957 0.8317012405243933 0.9328073518746235 0.9602668826406346 0.8249633776401786 0.9996856088893457 0.884539155829103 0.8520255369320877 0.8414815498004441 0.9248215209226829 1.0 15.914131326232747 -7.204531604591667 0.006489840426025862 1.808517171724698 9.542271074876298e-07 0.1038176064581594 0.0607998270164994 16155.978871041812 59.336136665868935 8174.220275428974 8356.27889382219 6.244079090513627e-08 7.204531604591667 -1.8085162174975904 HAPTYTIPLSPVLS(ph)PTLPAEAPTAQVPPSLPR ddPTM_A459_Selumetinib_30min_R1 1 HAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPR 32 0 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 HAPT(0.002)YT(0.005)IPLS(0.378)PVLS(0.607)PT(0.008)LPAEAPTAQVPPSLPR 106.6 6.6532e-12 54209000.0 917.98 1073.4 1075.9 1223.1 1305.6 1013.2 1130.6 1144.3 497.48 1058.8 True False 939.3671479218609 947.7258289898786 929.7986894956666 1009.508545430524 1187.5087105224018 1003.008127911995 1045.3179317487184 1113.9494467897546 844.187225498388 1194.7072935853676 0.7862738873073923 0.7932703132210007 0.7782648473713599 0.8449839980477107 0.9939746052429608 0.8395429853800631 0.8749573534548991 0.9324036546615069 0.706605902576309 1.0 10.222441482098905 -5.9442654894256775 5.185328524213523 0.8873659413095767 0.7884840320633797 0.26428830935807546 0.07838355204428026 0.27733410137723585 15.64869179118732 0.021587978035561096 0.03223081491090154 1.136932053142694e-06 5.9442654894256775 -0.098881909246197 HAQDSDPRS(ph)PTLGIAR ddPTM_A459_Selumetinib_30min_R1 1 HAQDSDPRSPTLGIAR 16 1 F5GX58;F8WDL1;Q99618;J3KMY0 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 HAQDS(0.007)DPRS(0.747)PT(0.246)LGIAR 81.128 0.012135 12437000.0 1771.7 1990.2 2251.6 2434.8 2424.1 1960.5 2201.2 1756.8 1100.5 1428.7 True False 1812.9771628719152 1757.1864587811212 1945.845087153493 2009.6078868565462 2204.8405830096153 1940.7791499915754 2035.1617118037116 1710.2039571093612 1867.468122660159 1612.0875617164857 1.1246145717677583 1.0900068336921724 1.207034365479277 1.2465873036802027 1.3676928197758627 1.2038918952548163 1.2624386913802335 1.0608629442487636 1.158416060646082 1.0 10.65471439169383 -8.357715582193523 1.1450144056797824 1.013868506475632 1.2134211259899021 0.36192773797941225 0.08199637231201642 0.5425150494405481 1.5012570066409499 0.08395125379638173 0.027199528086504554 4.388179839241818e-09 8.357715582193523 0.19955261951427006 HAQDSDPRS(ph)PTLGIAR ddPTM_A459_Selumetinib_30min_R2 2 HAQDSDPRSPTLGIAR 16 1 F5GX58;F8WDL1;Q99618;J3KMY0 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 HAQDS(0.002)DPRS(0.972)PT(0.027)LGIAR;HAQDSDPRS(0.657)PT(0.342)LGIAR 77.633 0.01176 23935000.0 50386.0 38479.0 53772.0 60631.0 60637.0 36408.0 38590.0 40523.0 32588.0 52741.0 True False 47585.747831139095 41430.21557051406 50312.36806252694 52372.95320569114 53019.23795834209 41422.871521082205 40384.511464634335 40640.91522105622 39106.510584797696 51218.23029242521 0.9290783293263585 0.8088958820711398 0.9823136757219775 1.0225451544630333 1.0351634106769059 0.8087524946602526 0.7884792433097186 0.7934853467021625 0.7635271730694931 1.0 15.644369784916497 -6.783105437981176 24.968030348404522 0.8152935255320098 0.9526524468084308 0.34392459963599475 0.08475149893440849 259.41922500928246 298953.4031659537 0.03072438635382617 0.02711938991206373 1.6477622993550025e-07 6.783105437981176 0.1373589212764209 HAS(ph)APSHVQPSDSEK ddPTM_A459_Selumetinib_30min_R1 3 HASAPSHVQPSDSEK 15 0 A0A3B3IRT3;O60343-2;O60343-3;O60343 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 HAS(0.902)APS(0.098)HVQPSDSEK;HAS(0.977)APS(0.023)HVQPSDSEK;HAS(0.994)APS(0.006)HVQPSDSEK 91.065 0.0098689 56814500.0 18592.4 19115.7 20645.699999999997 20697.0 21269.0 18019.1 20278.8 18663.7 7235.3 14832.5 True False 19025.566745487253 16877.62495735216 17842.127338712395 17082.65748080743 19345.222705346936 17837.844214033772 18749.15378944446 18168.6780477584 12277.775654596137 16736.39585578482 1.1367780082060617 1.0084384417519932 1.066067479071092 1.0206891392869946 1.1558774584469687 1.0658115622825832 1.120262328341376 1.0855788907190864 0.7335973503729244 1.0 14.030701259838223 -8.237144335192475 24.757797758040002 0.8667986862020888 1.0805218960686114 0.5742689008521931 0.07425266791144552 383.86702951130724 391179.9722939184 0.04637210714694803 0.017507851013508016 5.792361587360818e-09 8.237144335192475 0.2137232098665226 HAS(ph)APSHVQPSDSEK ddPTM_A459_Selumetinib_30min_R2 3 HASAPSHVQPSDSEK 15 0 A0A3B3IRT3;O60343-2;O60343-3;O60343 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 HAS(0.988)APS(0.012)HVQPSDSEK;HAS(0.976)APS(0.024)HVQPSDSEK;HAS(0.997)APS(0.003)HVQPSDSEK 115.91 0.0015342 82845300.0 331420.0 316164.0 376448.0 413197.0 434884.0 327475.0 329208.0 327635.0 234092.0 378004.0 True False 313001.0031793779 340412.7621725097 352227.74552559253 356918.85579541756 380249.98400771245 372581.7087279283 344516.8243132764 328588.3636071056 280916.9410769748 367090.04234766 0.8526545726428176 0.9273276932151566 0.95951321172588 0.972292393203601 1.0358493561304207 1.0149599982204565 0.938507680867559 0.8951165264676655 0.7652535036919546 1.0 18.48577445498571 -10.651937315058657 4.8012148014345435 1.0000042053828961 0.9361174020093914 0.06798892368633269 0.07479516788844197 3.619498546440348e-06 6.566674372534931e-07 0.07785353994262144 0.01888101407507119 2.2287568190453605e-11 10.651937315058657 -0.06388680337350472 HAS(ph)PILPITEFSDIPR ddPTM_A459_Selumetinib_30min_R1 3 HASPILPITEFSDIPR 16 0 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 HAS(0.997)PILPIT(0.002)EFSDIPR;HAS(0.998)PILPIT(0.002)EFSDIPR;HAS(0.999)PILPIT(0.001)EFSDIPR 111.43 0.0026221 16424900.0 1669.42 2414.69 2643.4300000000003 2749.89 2541.86 2408.9799999999996 2561.8199999999997 2622.12 1285.48 2369.81 True False 1708.3142378741509 2131.976972241074 2284.466725321618 2269.673333328381 2311.949211801831 2384.747848378835 2368.579854866885 2552.5728597538696 2181.3656722555015 2673.998197404174 0.6388614022000927 0.7972993303850108 0.8543262024407123 0.8487938905612211 0.8646038782098628 0.8918285175711288 0.8857821434458039 0.9545903442387583 0.8157693129236575 1.0 11.384782777544013 -3.9363666068124537 0.727807524318588 0.8999308059760304 6.880451116774967e-30 0.7345094286019478 0.047493878940051394 4.25777057401191 0.6945271188431243 0.01741869937788106 4.179256344174396 0.00011577995946629812 3.9363666068124537 -0.8999308059760304 HAS(ph)PILPITEFSDIPR ddPTM_A459_Selumetinib_30min_R2 6 HASPILPITEFSDIPR 16 0 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 HAS(1)PILPITEFSDIPR;HAS(1)PILPITEFSDIPR;HAS(0.933)PILPIT(0.04)EFS(0.027)DIPR;HAS(1)PILPITEFSDIPR;HAS(1)PILPITEFSDIPR;HAS(0.998)PILPIT(0.001)EFS(0.001)DIPR 90.453 0.0081726 25019200.0 37970.5 19224.100000000002 40028.5 39587.4 26535.6 19034.35 52729.1 36884.600000000006 33495.2 31918.3 True False 35860.25161795474 20698.526654775844 37453.10988973552 34195.52782792593 23201.960696726128 21656.158935874282 55181.107630729486 36991.92807942574 40195.17593408356 30996.735745297137 1.1569041305710877 0.6677647228681571 1.2082920665418115 1.1031977079429764 0.7485291640829101 0.6986593399325921 1.7802231849236458 1.1934136672774713 1.2967551249386646 1.0 14.919828673370514 -7.240833161173758 24.99426263435758 1.3337158933571907 0.9308102414079293 0.35690578110433957 0.25415182638965533 872.3732185670261 1058144.5085579064 0.09589133586226521 0.07419222814759927 5.743370574979064e-08 7.240833161173758 -0.4029056519492613 HAS(ph)SGSFLPSANEHLK ddPTM_A459_Selumetinib_30min_R2 1 HASSGSFLPSANEHLK 16 0 O76003 O76003 GLRX3 Glutaredoxin-3 1 HAS(0.478)S(0.118)GS(0.404)FLPSANEHLK 111.09 0.0017735 5223600.0 17195.0 10629.0 18681.0 21760.0 22023.0 20865.0 18021.0 17666.0 15599.0 23522.0 True False 16239.370737038795 11444.21012237828 17479.08479833492 18796.250461906282 19256.27385188199 23738.96435638816 18859.01220793407 17717.40513523627 18719.235872476344 22842.858742504442 0.710916742956593 0.5009972810926536 0.7651881489688952 0.8228501814850123 0.8429887900173905 1.0392291360720234 0.8255977248960743 0.7756211836248378 0.8194786862488826 1.0 14.479455592226984 -5.555870365593817 2.6794579167794956 0.8709774264595378 0.6058905285314187 0.5676692578886925 0.09268957598093365 0.19650124098223065 2.8306005587505827 0.02649560322801232 0.057227905209025196 2.780543120036649e-06 5.555870365593817 -0.2650868979281191 HASSSPES(ph)PKPAPAPGSHR ddPTM_A459_Selumetinib_30min_R1 2 HASSSPESPKPAPAPGSHR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HAS(0.007)S(0.007)S(0.007)PES(0.979)PKPAPAPGSHR;HAS(0.002)S(0.009)S(0.007)PES(0.982)PKPAPAPGSHR 65.175 0.010451 8209900.0 2637.2 2717.41 2499.59 2869.89 3169.69 2619.58 3306.84 2216.83 1118.71 2138.41 True False 2698.6416289020785 2399.254373910365 2160.159407265054 2368.7175860073653 2882.9920991542203 2593.229403588336 3057.402396447842 2158.0324671213234 1898.3691626543794 2412.8957533773014 1.1184244595419517 0.9943464696111124 0.8952560027682526 0.9816908097632894 1.1948266290074616 1.0747374394267235 1.26710919531788 0.894374514149959 0.7867597097791128 1.0 11.236549871440616 -7.961275821530413 24.998871503687393 0.8757751785204219 1.0671970484362365 0.35363758267302137 0.11156750793820598 168.46893793912156 108757.03114198548 0.06424189470048815 0.03086072675295653 1.0932618123803871e-08 7.961275821530413 0.19142186991581467 HASSSPES(ph)PKPAPAPGSHR ddPTM_A459_Selumetinib_30min_R2 2 HASSSPESPKPAPAPGSHR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HAS(0.049)S(0.049)S(0.068)PES(0.833)PKPAPAPGSHR;HASS(0.001)S(0.002)PES(0.997)PKPAPAPGSHR 67.902 0.008579999999999999 8143100.0 4692.2 5826.0 10411.3 14644.9 15478.9 10927.0 7247.9 7416.6 7243.3 12222.599999999999 True False 4431.42630836484 6272.835466457413 9741.448292966346 12650.239356138387 13534.302198878257 12432.095064570018 7584.941711441392 7438.1810781157765 8692.162394711702 11869.701779871375 0.3733393130297214 0.5284745634549032 0.820698655587614 1.0657588194499248 1.1402394474501212 1.047380574097687 0.6390170412119306 0.6266527345050433 0.7322982966136403 1.0 13.534996068016598 -5.190317706448441 2.8348947324896594 0.8872845468063081 0.3983796383475152 0.5194792048212352 0.17039960731031423 0.2595260491280796 3.972358940058756 0.05337303531971654 0.18570261508206093 6.451820759026676e-06 5.190317706448441 -0.48890490845879286 HATAEEVEEEERDR ddPTM_A459_Selumetinib_30min_R1 2 HATAEEVEEEERDR 14 1 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 ; 91.123 0.01384 16857400.0 1272.51 1503.67 1218.38 1520.73 1637.0 1306.77 1426.31 1291.81 790.08 1118.8600000000001 False True 1302.1570071265676 1327.619617362782 1052.9306880822846 1255.1630531375695 1488.933639035823 1293.6250802522277 1318.7222883712313 1257.5470024097467 1340.708054839925 1262.4765796193094 1.031430624653032 1.051599402947432 0.8340199771466558 0.9942070002724761 1.179375255804587 1.024672537404465 1.0445518829100833 0.9960953119533915 1.0619666744583933 1.0 10.302040909136037 -6.014897852109766 24.815923281885667 1.052676681768415 0.9692480363328809 0.20286466284752447 0.07204193998086797 967.0709195283531 1610890.2907060583 0.021527258370208916 0.028810329561776062 9.662781249465369e-07 6.014897852109766 -0.08342864543553408 HAVSDPSILDSLDLNEDER ddPTM_A459_Selumetinib_30min_R2 1 HAVSDPSILDSLDLNEDER 19 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 145.91 8.028e-05 0.0 8617.0 4475.8 4727.3 7009.6 9680.6 7398.1 7500.8 9345.6 7971.1 5815.9 False True 8138.101636584085 4819.079468034692 4423.150664695074 6054.88038776554 8464.436482337947 8417.121121734739 7849.602062553228 9372.794148752639 9565.54273114278 5647.979855477061 1.4408871569703383 0.853239492942144 0.7831385341089303 1.0720435523320593 1.4986661955123053 1.4902888000870498 1.389807021875471 1.6594949678624442 1.6936219632346436 1.0 12.463519227652347 -6.219716208908359 4.662817583646107 1.4881020434341652 0.9986378580535527 0.41249313783123376 0.24178605903594094 0.18405572186253477 9.453243971020191 0.07211310515981444 0.09200406637446551 6.029534592009897e-07 6.219716208908359 -0.48946418538061254 HAVSEGT(ph)KAVTK ddPTM_A459_Selumetinib_30min_R1 1 HAVSEGTKAVTK 12 1 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;A0A2R8Y619;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 1 HAVS(0.006)EGT(0.992)KAVT(0.002)K 146.0 0.021502 0.0 1119.9 869.83 1183.0 1140.5 1287.9 824.67 943.17 1278.5 685.2 730.77 True False 1145.9914910539349 767.9898992270038 1022.3550977538561 941.3330848364919 1171.4096723972127 816.37456854045 872.0259275494768 1244.59002684672 1162.734354972049 824.5714478025867 1.389802538164407 0.9313806599460023 1.239862355746547 1.1416028136131382 1.4206284676954564 0.9900592249659133 1.0575504765212915 1.5093780292337886 1.4101074662124646 1.0 9.687500696081008 -7.749705316008807 24.99887110473279 1.3448071070172567 1.1629305154218958 0.08925120050356827 0.19211899459909867 387.2930628085957 825113.570883382 0.08778804761391708 0.05014735155027997 1.7794864442577942e-08 7.749705316008807 -0.18187659159536085 HAVSEGT(ph)KAVTK ddPTM_A459_Selumetinib_30min_R2 1 HAVSEGTKAVTK 12 1 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;A0A2R8Y619;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 1 HAVS(0.231)EGT(0.769)KAVTK 64.64 0.045818 9128500.0 137530.0 126230.0 118790.0 122400.0 108110.0 100660.0 103080.0 99447.0 66512.0 92591.0 True False 129886.63317621096 135911.43510657744 111147.18072877298 105728.90884822252 94528.25528433725 114525.00129949822 107873.42424914507 99736.37430566292 79816.25850055426 89917.65724969095 1.444506420085332 1.5115099666038572 1.2360996063334935 1.1758414540831013 1.0512757802601909 1.2736653156062054 1.1996912236001993 1.1091967624190489 0.8876594535699894 1.0 16.456316827049093 -1.5228787454361665 0.24219704612674586 0.9873991283745559 4.211865753564677 0.7042854995099468 0.09891024684967442 29.745538516047727 0.39904669851434543 0.14260376566744343 38.666386296519896 0.029999999989235717 1.5228787454361665 3.224466625190121 HAYGDQYR ddPTM_A459_Selumetinib_30min_R1 2 HAYGDQYR 8 0 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 ; 153.04 0.0012876 15036200.0 4570.2 5715.4 5551.8 6168.1 5877.5 4857.8 5354.9 4821.2 2782.0 4705.6 False True 4676.67676793883 5046.238310982627 4797.896053854484 5090.957124576905 5345.881162756907 4808.934942529495 4950.975581745279 4693.32611453532 4720.850810759254 5309.609596425486 0.8807948462137863 0.950397240953428 0.9036250154972796 0.9588194823220558 1.00683130570576 0.9057040551092393 0.9324556715202478 0.8839305469266406 0.889114486672882 1.0 12.37439007149057 -5.203459739672731 0.00343802158706164 1.848211939054344 1.0888954402025097e-07 0.07295421497570509 0.04256454882710015 240973.70427257294 148.831419269055 39142.37363720704 40877.57713489182 6.259508886503201e-06 5.203459739672731 -1.8482118301648 HAYGDQYR ddPTM_A459_Selumetinib_30min_R2 2 HAYGDQYR 8 0 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 ; 137.9 0.003515 27641900.0 21790.2 22127.0 21418.8 26295.9 29872.5 19084.7 20453.2 23004.1 18810.8 21768.0 False True 20579.18791708188 23824.069750481176 20040.73772702618 22714.35305704232 26119.649486461636 21713.444191342493 21404.314327246942 23071.038122466227 22573.485617666385 21139.50127994373 0.97349448525574 1.1269929898055093 0.9480232036523958 1.074498057274073 1.2355849431151367 1.027150257889163 1.012526929741453 1.0913709749791995 1.0678343504292203 1.0 14.367653720818812 -4.7340660878562675 24.229981571881037 1.0669093516900954 0.9734937673262406 0.11808599864803104 0.07474445045543454 4678.669936298297 4141089.420812259 0.01881631445697329 1.6242200237568125 1.8447346791702713e-05 4.7340660878562675 -0.09341558436385478 HCAPS(ph)PDRS(ph)PELSSSR ddPTM_A459_Selumetinib_30min_R1 4 HCAPSPDRSPELSSSR 16 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 2 HCAPS(1)PDRS(1)PELSSSR;HCAPS(1)PDRS(0.886)PELS(0.107)S(0.007)SR;HCAPS(0.987)PDRS(0.982)PELS(0.028)S(0.002)S(0.001)R;HCAPS(1)PDRS(0.924)PELS(0.013)S(0.037)S(0.026)R 234.36 3.0196e-14 37428800.0 5799.09 7329.200000000001 6994.59 7856.3 7535.400000000001 6261.42 7734.9 6577.300000000001 3427.9999999999995 5575.32 True False 5934.197513935141 6471.093856747364 6044.763096532661 6484.344686015722 6853.824400482921 6198.435799714488 7151.450265596287 6402.848637918601 5817.065628786027 6290.966630215688 0.9432886649617603 1.0286326787470974 0.9608639580918288 1.030739005174695 1.0894707925430427 0.9852914765027091 1.1367808297134612 1.0177845495421227 0.9246696049612628 1.0 12.619065994210846 -4.7589967876588775 24.026895569180912 1.0232384213997323 0.943288489316126 0.13330507941303338 0.057428293079955436 81.89037801669838 805233.7207249012 0.014335826742924251 0.09325853966982856 1.7418197570426238e-05 4.7589967876588775 -0.07994993208360635 HCAPS(ph)PDRSPELSSSR ddPTM_A459_Selumetinib_30min_R2 1 HCAPSPDRSPELSSSR 16 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 HCAPS(0.653)PDRS(0.298)PELS(0.016)S(0.016)S(0.016)R 51.03 0.047363 4104100.0 8941.5 7185.5 7309.4 7393.8 9099.3 7037.7 8986.0 6249.7 6619.3 8861.3 True False 8444.567225660505 7736.60474497593 6839.1211618729885 6386.7516849835765 7956.164585225891 8007.079293120202 9403.8668054212 6267.885592306467 7943.344958694958 8605.451244577609 0.9813044064344123 0.8990353352882977 0.7947428865142191 0.7421751054609647 0.9245493767963835 0.9304659413607802 1.0927802085156988 0.7283622222897296 0.9230596668245781 1.0 13.071035129599915 -6.468573439038181 24.993356259610465 0.9277870800788253 0.8507672113649645 0.12139626315991159 0.10321723616059814 751.173684849813 345718.0933154846 0.0332580906963697 0.03771093528665854 3.3995901399825406e-07 6.468573439038181 -0.0770198687138608 HCAPSPDRS(ph)PELSSSR ddPTM_A459_Selumetinib_30min_R1 1 HCAPSPDRSPELSSSR 16 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 HCAPS(0.018)PDRS(0.973)PELS(0.008)S(0.001)S(0.001)R 63.754 0.025869 6248500.0 1032.9 890.78 779.95 1059.4 1055.2 661.15 731.69 782.7 451.34 649.26 True False 1056.964560326466 786.4870634876129 674.0370739586814 874.3956774009467 959.757346310691 654.4994312761695 676.4980342130015 761.9402534320903 765.8910154306553 732.5988453279521 1.442760341579995 1.0735576072817006 0.9200629761529925 1.1935531743972632 1.31007215262679 0.8933940251887499 0.9234221955539164 1.0400511252389477 1.0454439292595388 1.0 9.516879616946026 -6.772335555736513 24.999987925402813 0.9794004488531362 1.1670662636726068 0.36199866464262687 0.13634856511664187 286.441371881014 657201.7862683609 0.050425173973852384 0.044898336955951114 1.689135324284091e-07 6.772335555736513 0.18766581481947064 HCECAEEGTR ddPTM_A459_Selumetinib_30min_R2 2 HCECAEEGTR 10 0 Q86VP6-2;Q86VP6;A0A0C4DGH5 Q86VP6-2 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 ; 147.74 0.0011423 3091800.0 8494.6 7217.6 8263.0 10449.7 8272.8 10075.3 16120.3 34378.0 16484.9 22885.4 False True 8022.504138578069 7771.166711758166 7731.367576074162 9026.432833262035 7233.496904229636 11463.081120532843 16869.925891768464 34478.03428841572 19782.340626590514 22224.639038589863 0.3609734279440109 0.34966447366207665 0.34787370731420036 0.40614530645869856 0.3254719634217554 0.515782555596465 0.7590641117939546 1.551342823995909 0.8901085228984529 1.0 14.439872367267474 -7.418152417311683 2.7947000197383893 1.1659843867218884 0.37359724968915986 0.794028755135788 0.17295301879745717 0.10658018691998036 1.6115849815374288 0.07893987014752063 0.04764651243570652 3.818102495544441e-08 7.418152417311683 -0.7923871370327286 down HCFTSNEAAR ddPTM_A459_Selumetinib_30min_R2 1 HCFTSNEAAR 10 0 H7C0R6;H7C3J3;Q9BV44 H7C0R6 THUMPD3 THUMP domain-containing protein 3 0 141.91 0.0017660999999999996 500730.0 2486.1 2821.8 2299.7 3304.4 2291.5 1968.2 2463.4 1105.0 894.89 2999.9 False True 2347.9325146468254 3038.222986482929 2151.7398057240416 2854.335019592054 2003.6212837300795 2239.3016844592958 2577.9529811344955 1108.215367057402 1073.8930053157483 2913.2850923237415 0.805939837756843 1.0428855708246296 0.7385956875259798 0.9797650861953002 0.6877532477028944 0.7686517499985378 0.8848955386917615 0.3804005896908117 0.3686192635747751 1.0 11.508431174316165 -7.748744663525283 24.99738215747058 0.530882436644593 0.8439658665093954 0.2665711242743186 0.19270565272264667 230.28342900809 453457.04381628725 0.08704753346738199 0.04983031833707213 1.783426996570289e-08 7.748744663525283 0.3130834298648024 HCGLSLSS(ph)TPPGK ddPTM_A459_Selumetinib_30min_R1 1 HCGLSLSSTPPGK 13 0 D6R9S4;Q09GN1;Q71F23-3;Q71F23 D6R9S4 CENPU;MLF1IP Centromere protein U 1 HCGLSLS(0.01)S(0.552)T(0.437)PPGK 77.77600000000002 0.028069 14179000.0 3986.8 4513.1 5561.7 5598.4 5636.9 4700.4 5137.4 4911.6 2303.7 3137.2 True False 4079.6846830376176 3984.704153916733 4806.451688231291 4620.744534983438 5127.043390275522 4653.118243621729 4749.881781855529 4781.328412874734 3909.2106444090937 3539.8901789157703 1.1524890538517159 1.1256575635171835 1.3577968369921167 1.3053355616808207 1.4483622742911983 1.3144809608322165 1.3418161416833463 1.3506996463769398 1.1043310517634313 1.0 11.789488887684692 -8.433231285194541 3.758864265366458 1.0027303051610585 1.3022989953362858 0.5529532961864979 0.09105133432052652 0.17088136715624885 4.326549646770878 0.09590671133768085 0.025291892381063903 3.6878115044696654e-09 8.433231285194541 0.29956869017522725 HCGLSLSST(ph)PPGK ddPTM_A459_Selumetinib_30min_R2 3 HCGLSLSSTPPGK 13 0 D6R9S4;Q09GN1;Q71F23-3;Q71F23 D6R9S4 CENPU;MLF1IP Centromere protein U 1 HCGLSLS(0.017)S(0.14)T(0.843)PPGK;HCGLSLSS(0.017)T(0.983)PPGK;HCGLSLSS(0.062)T(0.938)PPGK 160.67 0.00085102 21061300.0 153428.0 121200.0 177743.0 191249.0 205498.0 134519.0 129950.0 144458.0 134710.0 176207.0 True False 144901.0859809472 130495.65028057648 166307.20889194636 165200.55627707345 179681.5040645708 153047.77120809868 135992.93249104012 144878.34886369054 161655.76411188432 171119.44606923242 0.8467832809739364 0.7625997703836643 0.9718779058264418 0.9654107704990801 1.0500355639993966 0.8943914600224793 0.7947251794867275 0.8466504081895805 0.9446954617097157 1.0 17.384644191911775 -7.873770735091375 0.011464414351009047 1.8327032198727298 4.341380649629242e-06 0.1057525057136599 0.08406638935349946 2481.725015592248 28.903641885206827 2303.6818454360823 2311.9454390179203 1.3373012942149371e-08 7.873770735091375 -1.8326988784920801 HCNGVDWR ddPTM_A459_Selumetinib_30min_R2 4 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 ;;; 116.37 0.013185 23779300.0 21500.899999999998 18043.9 21419.2 23875.2 26241.3 20894.0 21976.2 23406.2 19328.2 20708.9 False True 20305.966052922213 19427.809109716953 20041.11199146167 20623.356572982753 22944.633293801508 23771.95884315238 22998.136845014178 23474.308166895007 23194.380075030265 20110.980248816002 1.0096954898117256 0.9660299433122227 0.9965258651497881 1.0254774415681163 1.1409007920015402 1.1820387941831882 1.1435612068868772 1.1672383880083128 1.1533192210457166 1.0 14.295695782706373 -6.171892531593698 3.1489854283777547 1.1435491508841829 0.9902907405791131 0.6354983632997144 0.04882328050883287 0.14426869557486074 2.762202544533053 0.014297028794478665 0.018917665301105183 6.731432084302034e-07 6.171892531593698 -0.1532584103050697 HCQLEPDHEGVPEETDDFGEFR ddPTM_A459_Selumetinib_30min_R2 2 HCQLEPDHEGVPEETDDFGEFR 22 0 E9PFH4;C9J7E5;Q9Y5L0-5;Q9Y5L0-3;Q9Y5L0;Q9Y5L0-1 E9PFH4 TNPO3 Transportin-3 0 ; 115.88 1.8906e-05 4662200.0 14437.7 11449.400000000001 13028.599999999999 12251.2 16701.9 12022.900000000001 11287.0 12012.2 9658.0 12301.0 False True 13635.310432692355 12327.532164376506 12190.354060467125 10582.565425501203 14603.658005119538 13678.945341980321 11811.867864766196 12047.15351327324 11589.86986706689 11945.83816816372 1.1414276872619258 1.031952048139244 1.0204687095925218 0.8858788539178682 1.22248918824625 1.1450804162436607 0.9887851901631681 1.0084812253174107 0.970201479704831 1.0 13.544220462195124 -7.330771077312522 24.998212494670764 0.9925735642419717 1.0683039111192099 0.18190901194661668 0.08527981043826036 360.25248120187587 129890.56070550597 0.038111430648826834 0.02569472550700646 4.669054278336252e-08 7.330771077312522 0.07573034687723812 HCSTTPAGNS(ph)LPEYPK ddPTM_A459_Selumetinib_30min_R1 1 HCSTTPAGNSLPEYPK 16 0 O94991-2;O94991 O94991-2 SLITRK5 SLIT and NTRK-like protein 5 1 HCSTTPAGNS(1)LPEYPK 80.632 0.022833000000000003 5886800.0 0.0 152.3 170.29 0.0 158.27 124.23 0.0 0.0 114.59 142.36 True False 0.0 134.46864519765086 147.1655533360136 0.0 143.95450644483802 122.98035899181512 0.0 0.0 194.45086067753525 160.63329270382792 0.0 0.8371156622281356 0.9161584803428898 0.0 0.8961685589690185 0.765596950182448 0.0 0.0 1.2105265191572672 1.0 7.32762712522593 -8.282649900814187 24.661995754586822 1.1052635058074434 0.455338604847843 0.32727960979786874 0.387323363935201 988.1253500379553 1148904.6864137005 0.37963158348738285 0.09843725700850287 5.216150328426985e-09 8.282649900814187 -0.6499249009596004 HDADGQATLLNLLLR ddPTM_A459_Selumetinib_30min_R1 2 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 ; 168.93 8.819200000000001e-05 7513500.0 2248.14 2849.56 3157.5 3578.4 2647.33 2676.96 2908.1 2479.1499999999996 1446.02 2151.12 False True 2300.517287881054 2515.932190475497 2728.7288429060013 2953.499614887242 2407.8794689240744 2650.0322128852067 2688.7396756752587 2413.394888585877 2453.7903268778205 2427.2372056831837 0.9477925282681787 1.0365415397327633 1.1242118555685034 1.2168154014662664 0.9920247857466157 1.0917895484958644 1.1077366766543408 0.9942970892729825 1.0109396482274022 1.0 11.245099389747951 -7.772232098877313 24.971840328065003 1.0019637459016983 1.0773892362935145 0.1820405220388931 0.06975276742494507 387.0620573302841 895557.2642200193 0.039499176510066764 0.019273838425201993 1.6895377550286205e-08 7.772232098877313 0.07542549039181612 HDADS(ph)FYQFS(ph)CNICGKK ddPTM_A459_Selumetinib_30min_R1 1 HDADSFYQFSCNICGKK 17 1 A0A0A6YYC7;Q96JP5-2;Q96JP5;H3BTR0 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 2 HDADS(0.533)FY(0.469)QFS(0.998)CNICGKK 52.254 0.025488 1564400.0 76.417 0.0 0.0 139.61 111.5 138.81 73.545 154.93 0.0 131.48 True False 78.19736741840217 0.0 0.0 115.22973430427231 101.41484468692386 137.41369742939588 67.99744143858082 150.82075311643513 0.0 148.35673872365336 0.5270900943978132 0.0 0.0 0.7767071135131429 0.6835877194350506 0.9262383266954844 0.4583373968960104 1.016608712310477 0.0 1.0 7.212926648796454 -5.766393196520878 24.99998211712513 0.6945504605252519 0.15812699517288942 0.3649556418040425 0.3133543337391917 118.71481337840886 599111.1968844245 0.08251706495773016 0.12684342312894842 1.712406246888313e-06 5.766393196520878 -0.5364234653523625 HDDGTQS(ph)DSENAGAHR ddPTM_A459_Selumetinib_30min_R1 3 HDDGTQSDSENAGAHR 16 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 HDDGTQS(0.999)DS(0.001)ENAGAHR;HDDGT(0.001)QS(0.997)DS(0.002)ENAGAHR;HDDGT(0.002)QS(0.997)DS(0.002)ENAGAHR 132.74 0.00039309 1420660.0 307.23 646.36 377.39 741.6299999999999 439.4 494.92 418.62 376.99 416.776 627.33 True False 314.3878612344855 570.6838707153879 326.14251085488365 612.1182426192781 399.65634758237087 489.94155415140574 387.04315636710464 366.9910005638988 707.2384318853343 707.8539162116632 0.44414229268808186 0.8062170140551168 0.4607483315206526 0.8647522159589803 0.5646028628636777 0.6921506583922084 0.5467839444026903 0.518455845420739 0.9991304924473359 1.0 9.46730784372315 -8.271176875681268 24.87849866609899 0.9995653555125577 0.6209604842257964 0.5778198050287573 0.13226525288819943 476.50641536096066 1217419.5251362445 0.11258723427734943 0.030534767852588785 5.3557848733859065e-09 8.271176875681268 -0.37860487128676124 HDDGTQS(ph)DSENAGAHR ddPTM_A459_Selumetinib_30min_R2 2 HDDGTQSDSENAGAHR 16 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 HDDGTQS(1)DSENAGAHR;HDDGTQS(1)DSENAGAHR 290.67 7.933099999999998e-75 33622000.0 69368.0 52721.0 77204.0 78501.0 87128.0 76158.0 78134.0 76487.0 53373.0 57134.0 True False 65512.804262105645 56764.531175266304 72236.77869335964 67809.02837822169 76182.20170579717 86648.07320650898 81767.38581958384 76709.5645068955 64049.091366220906 55484.39296804047 1.1807429217048773 1.0230720413209389 1.3019296928231459 1.2221279669993024 1.3730383920696192 1.5616656968098954 1.4737006470753429 1.3825430973189332 1.1543622979368953 1.0 15.759794396884837 -5.5872713002740575 1.6343197298710945 1.3551169111938652 1.1029826125564957 0.16606591379327995 0.16034327373902257 0.5642681605599763 2.9451785199812948 0.049638091129399146 0.13568780868705763 2.5865965842437357e-06 5.5872713002740575 -0.2521342986373696 HDDYYR ddPTM_A459_Selumetinib_30min_R2 4 HDDYYR 6 0 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 0 ;;; 156.93 0.004866399999999999 6302400.0 15507.099999999999 10608.72 11745.9 9283.869999999999 14887.100000000002 12825.0 19846.9 25809.8 16882.399999999998 22911.5 False True 14645.277461839742 11422.374711588764 10990.181581968953 8019.390890430966 13016.849405637397 14591.52733624147 20769.82017588627 25884.90224495759 20259.35173366848 22249.985463773934 0.658215147406918 0.5133654909656448 0.4939410679554148 0.3604222979600435 0.5850273217854742 0.6557994098467391 0.9334756739370649 1.1633671530753045 0.9105332570510448 1.0 14.441516773095985 -7.18180440802736 2.1028727554764965 1.0342463513120295 0.5109429471378416 0.8613900247628276 0.09161640112733305 0.11129717020852496 0.9637864583732054 0.044307143901488266 0.030321423303273382 6.579540915547913e-08 7.18180440802736 -0.5233034041741879 HDGGS(ph)PSIK ddPTM_A459_Selumetinib_30min_R1 1 HDGGSPSIK 9 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 HDGGS(0.971)PS(0.029)IK 147.62 0.0016190999999999998 10589000.0 4204.8 5109.4 4932.2 3854.7 4173.9 4199.7 3370.2 5078.8 5060.0 4106.8 True False 4302.763658883462 4511.189072704381 4262.434330635306 3181.5490066806 3796.371481961894 4157.454831022506 3115.983100636412 4944.093725732593 8586.450432222078 4633.9477836195565 0.9285308898156363 0.9735088273223292 0.9198278724034169 0.6865742030859713 0.8192521062454797 0.8971734307664417 0.6724251644895599 1.0669290973043255 1.8529450121501454 1.0 12.178026072339671 -8.011075006605083 20.546078346994552 1.4376285871778913 0.8474127708086497 0.5437992210536955 0.21248286481160195 32.27512423756891 59872.39306825543 0.11920706635183659 0.050949438439592945 9.748212626839444e-09 8.011075006605083 -0.5902158163692416 HDGGS(ph)PSIK ddPTM_A459_Selumetinib_30min_R2 1 HDGGSPSIK 9 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 HDGGS(0.945)PS(0.055)IK 94.82 0.015166 8540900.0 45453.0 39853.0 35595.0 41050.0 41320.0 41734.0 74069.0 158710.0 60980.0 122670.0 True False 42926.90422277549 42909.596952407715 33304.85645290572 35458.91918480019 36129.01219451316 47482.47967646795 77513.3552649392 159171.81982414506 73177.70392355962 119128.198365063 0.3603420920647849 0.36019680933067744 0.2795715616452495 0.2976534495731894 0.3032784234996775 0.3985830418668805 0.6506717664561921 1.3361388991745697 0.6142769296259298 1.0 16.862155422704014 -7.449087032772899 3.2987206356652248 0.9858063558531722 0.3294028793510331 0.7464546618291945 0.16899291207877426 0.11290345026101851 2.382931848938395 0.07465323293724253 0.04551264943870685 3.555600570634229e-08 7.449087032772899 -0.6564034765021391 down HDGSEPCVDVLFGDGHR ddPTM_A459_Selumetinib_30min_R1 1 HDGSEPCVDVLFGDGHR 17 0 Q96EL3 Q96EL3 MRPL53 39S ribosomal protein L53, mitochondrial 0 108.34 0.0013262 2667100.0 1230.2 1294.2 1485.8 1505.4 1240.1 1453.0 1326.1 1279.1 727.7 877.09 False True 1258.8612664474965 1142.674462342743 1284.036520915197 1242.5101498578297 1127.933173957437 1438.3841392184447 1226.071209350765 1245.174112897645 1234.8537508948634 989.673045080081 1.2719971233991056 1.1545979432533515 1.2974350744404652 1.2554753875885243 1.1397028337436113 1.4533932659568953 1.2388649114431074 1.2581671483200694 1.2477390962941133 1.0 9.9508081754222 -9.169591810674461 2.0803558318351763 0.999997589787894 1.258277162890072 0.4791128432681897 0.08061392188383175 11.693863945291925 36.40011344264682 0.07623237751738975 0.0209178548100068 6.767187181808565e-10 9.169591810674461 0.258279573102178 HDLDLICR ddPTM_A459_Selumetinib_30min_R1 4 HDLDLICR 8 0 P62136-3;P62136;P62136-2;E9PMD7;F8VYE8;F8W0W8;P36873;P36873-2;F8VR82;P62140 P62136-3;P62140 PPP1CA;PPP1CC;PPP1CB Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0 ;;; 148.99 0.002093 25568200.0 24003.100000000002 33080.6 23258.0 26800.699999999997 26533.5 25788.500000000004 25666.6 22177.8 13040.7 21251.399999999998 False True 24562.32552809779 29207.50797324629 20099.691347049175 22120.460856446618 24133.549609869908 25529.091104084553 23730.54769770179 21589.572700352885 22129.11544495623 23979.224196165538 1.024316938995278 1.2180339002759228 0.8382127454425014 0.9224844254962948 1.0064357967731519 1.0646337385746971 0.9896295019209373 0.9003449204084435 0.9228453457845749 1.0 14.549497363303667 -5.256584127347218 24.99997814183351 0.9577602789338402 1.1211754127288844 0.4417326816352095 0.07443507889640341 381.5268961927477 1964487.8380718462 0.01974429174369716 0.04882885837362776 5.538802411965329e-06 5.256584127347218 0.16341513379504424 HDLDLICR ddPTM_A459_Selumetinib_30min_R2 4 HDLDLICR 8 0 P62136-3;P62136;P62136-2;E9PMD7;F8VYE8;F8W0W8;P36873;P36873-2;F8VR82;P62140 P62136-3;P62140 PPP1CA;PPP1CC;PPP1CB Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0 ;;; 148.99 0.002093 27736300.0 142943.0 140457.0 158864.0 152372.0 169149.0 127172.0 124761.0 127053.0 113044.0 153747.0 False True 134998.80030616664 151229.60025956252 148642.86319804526 131618.67074363912 147898.99040875383 144688.78864752443 130562.63370923139 127422.70319524345 135655.95871326458 149307.92462732008 0.9041636647427139 1.0128705535023612 0.9955457057558409 0.8815250166537764 0.9905635670572541 0.9690630219974912 0.8744521366506308 0.8534222380580051 0.9085650279572803 1.0 17.18793121403604 -7.25342985929632 24.727949080717448 0.8968950366664693 0.9609863401915145 0.1624953031730325 0.052468729912823586 732.4839118769047 2261416.9807215533 0.019827216550133264 0.015085632812778717 5.57917701329429e-08 7.25342985929632 0.06409130352504522 HDLGHFMLR ddPTM_A459_Selumetinib_30min_R1 2 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 ; 117.81 0.010416 24950500.0 11096.9 13127.9 13427.0 13714.3 11482.6 10505.400000000001 10404.5 10380.5 6029.799999999999 8374.5 False True 11355.436179191367 11590.879365004865 11603.687149231631 11319.354954294691 10444.000857417692 10399.725214140019 9619.680188288992 10105.17541938395 10232.13020083255 9449.448649537833 1.2017035702656318 1.2266196468057178 1.227975046967334 1.1978852284517483 1.1052497605697345 1.1005642339406398 1.0180149705093624 1.0693931248441872 1.08282827711149 1.0 13.206014438992332 -6.430441048576972 1.4666750703032627 1.0505626965640458 1.2228013664804804 0.8913971537527925 0.026572312935665653 0.12098106062831591 0.5275740089330934 0.010373837007719829 0.012405835765118094 3.711581073230638e-07 6.430441048576972 0.17223866991643466 HDLSTEGDSR ddPTM_A459_Selumetinib_30min_R2 2 HDLSTEGDSR 10 0 Q8IVF2;Q8IVF2-3;Q8IVF2-2 Q8IVF2 AHNAK2 Protein AHNAK2 0 ; 120.06 0.0073141 4028400.0 34902.0 37981.0 41790.0 45427.0 44278.0 30508.0 41007.0 40963.0 33792.0 46402.0 False True 32962.286563776 40894.02057183643 39101.2768975117 39239.76423405406 38715.40178965767 34710.2000759497 42913.90675382897 41082.1955482103 40551.34422736848 45062.253693125174 0.7314833116925268 0.907500562451348 0.867716851531487 0.8707900963249113 0.8591536955366305 0.7702721730769801 0.9523249113564871 0.911676451603616 0.8998960527701061 1.0 15.459631848262344 -14.522878687264148 0.06543531661251654 1.5123621612828382 0.6713297811630419 0.45848422486431706 0.05529810709934714 341.7929409338847 1.6152745750889856 26.64596198403127 3.7712320118283675 3.000000400761665e-15 14.522878687264148 -0.8410323801197963 HDS(ph)PDLAPNVTYSLPR ddPTM_A459_Selumetinib_30min_R1 2 HDSPDLAPNVTYSLPR 16 0 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 HDS(1)PDLAPNVTYSLPR;HDS(1)PDLAPNVTYSLPR 111.93 0.0016775 67467000.0 7123.1 8719.3 8011.1 8532.4 8106.2 6836.9 8153.1 7146.2 4294.799999999999 6375.6 True False 7289.054370860149 7698.440302507401 6923.236621822409 7042.376512984552 7372.995641265846 6768.126993408521 7538.1051029015325 6956.659561870964 7287.961920218851 7193.970363603016 1.013217180840527 1.0701239945964591 0.9623665753266999 0.9789276514975049 1.0248854622154944 0.9408055150812136 1.0478365522659951 0.9670125410951516 1.0130653244127017 1.0 12.812572500797733 -5.260914021395037 24.999998086313052 0.991577378279101 1.0416705868941405 0.27202315737861116 0.03258970669059177 52.84408662018083 2514494.541668986 0.007815911758349288 0.01838525488327895 5.483855197312028e-06 5.260914021395037 0.05009320861503952 HDS(ph)PDLAPNVTYSLPR ddPTM_A459_Selumetinib_30min_R2 3 HDSPDLAPNVTYSLPR 16 0 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 HDS(1)PDLAPNVTYSLPR;HDS(1)PDLAPNVTYSLPR;HDS(1)PDLAPNVTYSLPR 99.409 0.0043426 107876000.0 90664.3 93505.7 103790.2 101931.4 105559.8 89486.0 88675.8 91570.3 69421.0 97871.8 True False 85625.54116394921 100677.28652178626 97112.45153022565 88048.16747852706 92298.43420741454 101811.88422697113 92799.4004077642 91836.7544127208 83307.1397848055 95045.98683252462 0.9008853926134234 1.0592481584644309 1.0217417354121667 0.9263743837356537 0.971092386783764 1.071185513664752 0.9763631637733532 0.9662349508195581 0.8764929752541419 1.0 16.536338092177665 -7.894024406935274 3.4221035337994765 0.9343586451854167 0.9936120316801372 0.10664848091372192 0.057318098843473594 0.4574234542869696 10.2862050681564 0.03588061818253864 0.015290983820775782 1.2763670761845414e-08 7.894024406935274 0.05925338649472056 HDS(ph)PEDVK ddPTM_A459_Selumetinib_30min_R1 1 HDSPEDVK 8 0 P31948-2;P31948-3;P31948;H0YGI8 P31948-2 STIP1 Stress-induced-phosphoprotein 1 1 HDS(1)PEDVK 97.597 0.020141 97038000.0 8607.0 11457.0 11023.0 9282.5 6689.3 9098.5 6516.6 9079.8 10792.0 8103.9 True False 8807.526353693378 10115.609113785209 9526.137145004861 7661.485629105425 6084.253996091836 9006.977350777022 6025.047615455239 8838.974208652991 18313.235783506076 9144.114503670635 0.9631907332479112 1.1062426120894042 1.041777980927609 0.8378597649920009 0.6653737760665062 0.985002686390403 0.6588989686247544 0.9666298694209096 2.0027347400510753 1.0 13.158627753923522 -8.085833299571856 10.168370397433677 1.499104517747094 0.8942078788707933 0.454271249247154 0.2633287810725289 0.4414635325299052 50.14309218616103 0.16773922613774697 0.06330946850617929 8.20666490083182e-09 8.085833299571856 -0.6048966388763007 HDS(ph)PEDVK ddPTM_A459_Selumetinib_30min_R2 1 HDSPEDVK 8 0 P31948-2;P31948-3;P31948;H0YGI8 P31948-2 STIP1 Stress-induced-phosphoprotein 1 1 HDS(1)PEDVK 77.533 0.035164999999999995 35123000.0 98157.0 98212.0 92992.0 80483.0 92540.0 69428.0 156710.0 248080.0 86648.0 181170.0 True False 92701.82689360391 105744.5445986469 87008.9959620341 69521.07655908083 80914.29788190349 78991.07679536639 163997.3255149739 248801.8717281452 103980.02114740227 175939.1513638096 0.5268970901304036 0.6010290704425802 0.49454027308632176 0.3951427298596213 0.45989933027804425 0.448968158497181 0.9321252503705545 1.4141359089181293 0.5909999016216171 1.0 17.424717032820148 -7.3200365984927 4.88905353337013 1.0291837578605343 0.4872851326180301 0.6143463294778602 0.1923601872143742 0.13329464436863275 6.713501944796095 0.07840308149958969 0.05259927440879206 4.785897593168192e-08 7.3200365984927 -0.5418986252425042 HDSIPAADTFEDLS(ph)DVEGGGSEPTQR ddPTM_A459_Selumetinib_30min_R1 1 HDSIPAADTFEDLSDVEGGGSEPTQR 26 0 O95671;O95671-2;O95671-3 O95671 ASMTL N-acetylserotonin O-methyltransferase-like protein 1 HDSIPAADT(0.061)FEDLS(0.939)DVEGGGSEPTQR 125.31 4.9614e-09 3231700.0 621.02 674.13 572.58 747.41 910.38 458.21 855.77 573.6 146.08 344.1 True False 635.4885577054335 595.2025462054654 494.82678095680683 616.8888741233161 828.0362897406437 453.6008234213925 791.2185799156201 558.3862646846135 247.88709073893313 388.26858681783625 1.636724111300782 1.5329660096471216 1.2744445411159786 1.5888199433778594 2.1326378642347725 1.168265573939434 2.0378125008779957 1.4381443249401766 0.6384423029701194 1.0 8.600911179340487 -8.14398097730461 4.949040831678453 0.8301605483843479 1.615538813855718 0.5428826969797498 0.29031040582678036 0.16233502181489076 5.739918668892117 0.20253135829435517 0.07241055134029001 7.178257323367435e-09 8.14398097730461 0.7853782654713701 HDSIPAADTFEDLS(ph)DVEGGGSEPTQR ddPTM_A459_Selumetinib_30min_R2 1 HDSIPAADTFEDLSDVEGGGSEPTQR 26 0 O95671;O95671-2;O95671-3 O95671 ASMTL N-acetylserotonin O-methyltransferase-like protein 1 HDSIPAADTFEDLS(0.999)DVEGGGS(0.001)EPTQR 141.72 1.0654e-09 2246100.0 7650.3 6907.1 12869.0 21531.0 28137.0 12621.0 7351.1 7652.1 16004.0 17929.0 True False 7225.126952577375 7436.852360173017 12041.022550707785 18598.440656953313 24602.178512028495 14359.428187969095 7692.94071592831 7674.366344126646 19205.247189121823 17411.343184863606 0.41496666143818667 0.42712686099014907 0.6915619560687046 1.0681795459135914 1.4129971622991255 0.8247168547256213 0.4418349942476637 0.4407681970681209 1.103030764784289 1.0 14.087739882446247 -5.418642828021888 3.5403248086119183 0.8752646007903522 0.42214932362116897 0.31443052581543507 0.2787567188835521 0.3405615484133636 7.773635162718773 0.0853803186723371 0.19379247422226017 3.81379348025188e-06 5.418642828021888 -0.4531152771691832 HDSSTAVAGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 HDSSTAVAGSPR 12 0 Q9H1I8-3;Q9H1I8 Q9H1I8-3 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 HDSSTAVAGS(1)PR;HDSSTAVAGS(1)PR 121.32 0.0025238000000000005 2456600.0 849.45 1065.6100000000001 1049.6200000000001 1011.13 1053.16 905.83 705.9 982.79 368.73 856.23 True False 869.2405322580277 940.8478858113511 907.0873691499592 834.5551267608255 957.9018639505005 896.7181726278341 652.6533946766493 956.7232166481714 625.7078790263336 966.1354608864743 0.8997087545678728 0.9738260563876615 0.9388821815086512 0.863807572071811 0.9914778027830392 0.9281495286437922 0.675529903516645 0.9902578420735465 0.6476399059529576 1.0 9.916081671846204 -7.047498701709255 24.942138021054646 0.8238728306824343 0.934962666959452 0.17492998223416067 0.11081245041337488 631.6980021827156 331710.1503563898 0.03867496952277969 0.029958353832685868 8.963988656630477e-08 7.047498701709255 0.11108983627701763 HDSSTAVAGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 HDSSTAVAGSPR 12 0 Q9H1I8-3;Q9H1I8 Q9H1I8-3 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 HDSSTAVAGS(0.999)PR 97.957 0.017158 0.0 1282.8 2311.7 3511.7 4560.1 3767.7 3665.5 2149.3 3133.6 3714.3 4940.8 True False 1211.5071114552702 2488.9999567129435 3285.7610452498648 3939.0065133887297 3294.3678423346364 4170.389352903945 2249.246708757154 3142.718257204592 4457.263786213148 4798.146266259922 0.2524948270073518 0.5187419929682716 0.684798016341228 0.8209434008061455 0.6865917918134962 0.8691667826447267 0.4687741023181449 0.654985922230814 0.9289553796132007 1.0 12.22826142194985 -4.867966068739352 1.6032235174844445 0.7496006455197975 0.12175695705611897 0.5613782177188567 0.14409401739309258 0.6640020405205893 1.8906839026042932 0.04035634913965266 0.6251291006928027 1.3552952969143198e-05 4.867966068739352 -0.6278436884636786 HDT(ph)PDPSPLR ddPTM_A459_Selumetinib_30min_R1 1 HDTPDPSPLR 10 0 Q9BRD0;Q9BRD0-2 Q9BRD0 BUD13 BUD13 homolog 1 HDT(1)PDPSPLR 121.21 0.006573000000000001 5909700.0 567.26 856.16 1064.1 802.71 643.37 814.29 736.0 878.48 588.71 803.61 True False 580.4760543041834 755.9203891820144 919.601064682906 662.5317672328806 585.1772970961991 806.0989819161648 680.4829274430002 855.1798566948034 998.9978723228188 906.76117132427 0.6401642159604531 0.8336488295788387 1.0141601711285058 0.7306574081301838 0.6453488698039231 0.8889870976046602 0.750454418388026 0.943114773480943 1.1017210528146488 1.0 9.824578804125057 -7.9530372785650485 3.896794536026684 1.0467034042380932 0.7936598905390123 0.49997230544333826 0.1079617810150966 0.19194003794734604 6.050388046058275 0.07111113420232024 0.0298499320285708 1.1141988899208348e-08 7.9530372785650485 -0.25304351369908085 HDT(ph)PDPSPLR ddPTM_A459_Selumetinib_30min_R2 1 HDTPDPSPLR 10 0 Q9BRD0;Q9BRD0-2 Q9BRD0 BUD13 BUD13 homolog 1 HDT(1)PDPSPLR 89.44 0.041809 5044600.0 36500.0 40548.0 40117.0 36980.0 38130.0 23009.0 38655.0 38461.0 21403.0 30822.0 True False 34471.47612107685 43657.901217630504 37535.91589608703 31943.260205941802 33339.76851347502 26178.28089509396 40452.5340934294 38572.915142438665 25684.19804978595 29932.088774826618 1.1516562168580742 1.4585651387733263 1.254035967167629 1.0671911488117265 1.1138470410228878 0.8745891772548239 1.351477152087383 1.2886810350128028 0.8580823825227589 1.0 14.869405338637248 -5.647326954265571 4.637998343191993 1.0957737866479647 1.3161215766638275 0.25390989755877535 0.1631864960469121 0.29630002190794186 10.624008468810517 0.04515490874900484 0.08025814514785143 2.252542769318539e-06 5.647326954265571 0.2203477900158628 HDWDYCEHR ddPTM_A459_Selumetinib_30min_R2 1 HDWDYCEHR 9 0 P17568 P17568 NDUFB7 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0 69.27600000000001 0.043327 3822100.0 9620.6 4243.0 7853.6 6375.1 5965.6 6890.6 11543.0 7177.1 7003.6 6129.5 False True 9085.925566313199 4568.42445660467 7348.307926353145 5506.800382339093 5216.147994859335 7839.717603361052 12079.772372020581 7197.984172767132 8404.515696934119 5952.525408646412 1.526398451506873 0.7674766830845863 1.2344857723209837 0.9251200128167658 0.8762915967200336 1.317040594564011 2.029352508848423 1.209231994593692 1.4119243715828644 1.0 12.539286158385321 -6.977937155560596 11.481057340184377 1.4647349434042454 1.0553141898801894 0.2108121795060418 0.3144387670013376 0.7802127725563388 401.01892566431917 0.10711504304545026 0.09405774026853234 1.0521141086326201e-07 6.977937155560596 -0.40942075352405594 HDYDDS(ph)SEEQSAEDSYEASPGSETQR ddPTM_A459_Selumetinib_30min_R2 1 HDYDDSSEEQSAEDSYEASPGSETQR 26 0 P98175-5;P98175-2;P98175 P98175-5 RBM10 RNA-binding protein 10 1 HDY(0.008)DDS(0.552)S(0.439)EEQS(0.001)AEDSYEASPGSETQR 89.23899999999998 3.5348e-05 5841000.0 5641.7 4647.2 5850.6 4321.3 5733.3 4931.8 5166.8 5306.4 2618.8 4192.0 True False 5328.1568995145 5003.625296896823 5474.178765651642 3732.73148534171 5013.031597647687 5611.110683577054 5407.066437819969 5321.840745478187 3142.6331753856675 4070.96606787597 1.308818794034918 1.2291002217828528 1.3446878884224645 0.9169154011861528 1.2314108037415403 1.3783241103025592 1.3282022860586284 1.3072672817081137 0.7719625079128549 1.0 11.991155481106583 -8.255801990334795 24.981389612239354 0.8859812410470495 1.2520940427142044 0.5540346083581583 0.1326136175782434 317.70121419846873 1407869.6291502505 0.0984394335578617 0.03492276088894185 5.54878643390477e-09 8.255801990334795 0.366112801667155 HEAFESDLAAHQDR ddPTM_A459_Selumetinib_30min_R1 1 HEAFESDLAAHQDR 14 0 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;H7C5W8;F6THM6;Q08043;A0A494C060;A0A087WSZ2 O43707;P12814-4 ACTN4;ACTN1;ACTN2;ACTN3 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 0 82.48299999999998 0.016783000000000003 8079700.0 1304.3 1356.8 958.04 974.23 1077.5 1039.0 1376.3 1213.3 723.5 934.11 False True 1334.687652273996 1197.9452252407928 827.9434301370273 804.0990190620391 980.040315248076 1028.54860333652 1272.484582934513 1181.119342646167 1227.7266576507266 1054.0121175019153 1.2662925123074504 1.1365573557920845 0.7855160452038378 0.7628935243816852 0.9298188312776159 0.9758413458986167 1.2072769959707799 1.1205937038423288 1.1648126594222914 1.0 10.041675737746731 -7.1900987690030265 7.4918437559095175 1.1329514101939506 0.9623472012112871 0.18682813086634442 0.14810274575087665 0.48320098014693424 45.14677052085437 0.06269782864603628 0.048438816709466294 6.455074084412059e-08 7.1900987690030265 -0.17060420898266349 HEAFESDLAAHQDR ddPTM_A459_Selumetinib_30min_R2 1 HEAFESDLAAHQDR 14 0 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;H7C5W8;F6THM6;Q08043;A0A494C060;A0A087WSZ2 O43707;P12814-4 ACTN4;ACTN1;ACTN2;ACTN3 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 0 111.66 0.0021774 5610500.0 18060.0 16017.0 16984.0 23452.0 23607.0 17625.0 17523.0 16862.0 18178.0 12553.0 False True 17056.297499908163 17245.452397227677 15891.267930781025 20257.797143043466 20641.277610742312 20052.6837661798 18337.85422116578 16911.065628345637 21814.10793575708 12190.562273389092 1.3991395242810527 1.4146560273821789 1.3035713672920766 1.6617606873855546 1.693217847367088 1.64493509950341 1.5042664817188685 1.3872260564437608 1.7894259055938158 1.0 13.573477049422445 -10.74083656554954 4.098980485234365 0.9996963810398187 1.529536192869135 0.5294064642375891 0.15076012454946844 21484482.87623265 18765933.95342099 55737.01791353116 0.038233094193456066 1.8161990093379596e-11 10.74083656554954 0.5298398118293162 HEAPS(ph)SPISGQPCGDDQNASPSK ddPTM_A459_Selumetinib_30min_R1 1 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 HEAPS(0.554)S(0.446)PISGQPCGDDQNASPSK 135.34 3.7288e-06 32906000.0 7230.4 8169.4 7417.8 7865.3 8267.6 6958.6 8904.1 7517.3 3359.2 5676.6 True False 7398.854252090694 7212.92285014898 6410.503503058789 6491.77300496664 7519.797039763338 6888.602801903283 8232.456568267966 7317.916784368281 5700.317053739214 6405.246904766437 1.1551239729080338 1.1260959893336062 1.000820670673669 1.0135086283927346 1.1740058036119596 1.0754624925976168 1.2852676392758284 1.1424878530322826 0.8899449370948289 1.0 12.645038468252677 -8.254894632276237 24.82420071116443 0.9449724635092248 1.1197826831488762 0.4319866517704113 0.08099153517631358 426.599183281817 1618105.826092693 0.061286122888825956 0.02195087813221596 5.560391460954675e-09 8.254894632276237 0.17481021963965138 HEAPS(ph)SPISGQPCGDDQNASPSK ddPTM_A459_Selumetinib_30min_R2 1 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 HEAPS(0.547)S(0.453)PISGQPCGDDQNASPSK 111.97 9.2231e-06 41385000.0 129720.0 112360.0 135550.0 139340.0 149840.0 98130.0 104170.0 126630.0 95368.0 120350.0 True False 122510.68171030367 120977.65070565631 126828.86057568098 120361.6516250926 131015.75961340386 111646.51676455165 109014.11140893908 126998.47233527499 114444.26480455964 116875.18279314692 1.048218097139842 1.0351012748341126 1.0851650242990483 1.0298307027088571 1.1209887033527368 0.95526282052667 0.9327396013735366 1.0866162456408295 0.9792007342320939 1.0 16.83460909581835 -6.772997079116991 24.999989045756507 0.992550882808201 1.0615560294801039 0.3993919934647425 0.04474783897725579 250.91632685369768 542743.5376620858 0.01587414305834641 0.014120621432683412 1.6865643684770056e-07 6.772997079116991 0.06900514667190283 HEAPSS(ph)PISGQPCGDDQNAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 2 HEAPS(0.452)S(0.546)PIS(0.002)GQPCGDDQNAS(0.924)PS(0.076)K;HEAPS(0.284)S(0.71)PIS(0.006)GQPCGDDQNAS(0.926)PS(0.074)K 134.32 2.4533e-05 55216000.0 404510.0 374530.0 380440.0 392120.0 371490.0 272775.0 289103.0 298395.0 212918.0 331970.0 True False 382028.95358183037 403255.24669624015 355962.9045917538 338712.57955527084 324820.1050372631 310347.2802450893 302546.86234672635 299263.2800480484 255507.54942598363 322385.1635383553 1.185007862610213 1.2508492706993428 1.1041541139327387 1.050645680581926 1.0075528956487418 0.9626599339710811 0.9384639759041866 0.9282786985712014 0.7925536852305705 1.0 18.29842582567813 -5.886884594219626 0.7091440459650307 0.9028371087098203 1.2591539004435435 0.8155000468381968 0.05418522860763542 0.37981401514585916 0.3519318159769354 0.02868958469241068 0.08743314857070143 1.2975240183485445e-06 5.886884594219626 0.3563167917337232 HEAPSS(ph)PISGQPCGDDQNASPSK ddPTM_A459_Selumetinib_30min_R1 1 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 HEAPS(0.339)S(0.659)PIS(0.002)GQPCGDDQNASPSK 86.641 0.00016534 23012000.0 7863.7 9351.3 9249.8 9213.3 10507.0 8554.3 10714.0 8762.8 3917.7 7462.1 True False 8046.908909903412 8256.445448698569 7993.727965514461 7604.370110060539 9556.643705161518 8468.251508682955 9905.834354109116 8530.382078414106 6648.050762513132 8419.933222009236 0.9556974738076592 0.9805832458524351 0.9493813970661076 0.9031390047349948 1.1350023157168259 1.005738559368549 1.1764742181346304 1.0131175454118997 0.7895609843003859 1.0 13.039593076070368 -6.225341742384108 24.997215376939796 1.0277506442479627 0.9497405795073467 0.11485933998512843 0.09745937731608958 1330.824282770282 921580.9549206204 0.02956997449916597 0.03817364812658265 5.951936067651405e-07 6.225341742384108 -0.078010064740616 HEAPSS(ph)PISGQPCGDDQNASPSK ddPTM_A459_Selumetinib_30min_R2 1 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 HEAPS(0.211)S(0.789)PISGQPCGDDQNASPSK 139.63 2.1227e-06 38454000.0 107090.0 97928.0 118690.0 129840.0 135950.0 93512.0 99560.0 113950.0 83129.0 108530.0 True False 101138.36651523618 105438.76271185048 111053.61461990116 112155.56801350703 118870.7455915794 106392.42918258187 104189.73727439728 114281.57563456186 99757.12281832716 105396.45690519558 0.9595993023390761 1.0004013968580836 1.0536750274233053 1.0641303446698525 1.127843848664704 1.0094497700077543 0.9885506622686212 1.0843018730445415 0.9464940828898925 1.0 16.685466843392767 -10.469794057287658 14.826467563762932 0.9999909252197123 1.0303438778657164 0.014993230104829891 0.05405455519806713 0.0 0.0 0.05318357723105882 0.012898912145402942 3.3900487435126713e-11 10.469794057287658 0.030352952646004017 HEAPSSPISGQPCGDDQNAS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 HEAPSSPISGQPCGDDQNAS(0.915)PS(0.085)K 123.62 6.906000000000001e-06 5017800.0 2116.1 2684.9 1919.9 1817.5 2013.1 1804.9 2294.5 2142.5 965.07 2026.5 True False 2165.401012786171 2370.5506598238544 1659.1881252558144 1500.1077437004142 1831.015460441672 1786.7443447180792 2121.424017687453 2085.6739401791915 1637.6533040760005 2286.6210147815914 0.9469872789536141 1.036704659189131 0.7256069608956573 0.6560368919917839 0.80075161061028 0.7813906778464299 0.927754972937692 0.9121205161225227 0.7161892125934224 1.0 11.15900155753771 -9.928484209267054 24.90322699540746 0.9999999978287426 0.8338527784721084 0.16073375328553507 0.11398249082676729 0.0 0.0 0.11915087991457991 0.0288983331337117 1.1790053905183743e-10 9.928484209267054 -0.16614721935663423 HEAPSSPISGQPCGDDQNAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 HEAPSSPISGQPCGDDQNASPSK 23 0 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 HEAPSSPISGQPCGDDQNAS(0.93)PS(0.07)K 71.85300000000002 0.0012435 3639100.0 13123.0 13687.0 16385.0 15412.0 16204.0 13343.0 11771.0 14584.0 9686.8 16685.0 True False 12393.676195531274 14736.748889358498 15330.806938639134 13312.859012817076 14168.30865440201 15180.87713430565 12318.374823794005 14626.437025488827 11624.430671806134 16203.260697163789 0.764887785685054 0.9094927968379853 0.9461556673788895 0.8216160476358535 0.8744109546347065 0.9369026036199556 0.7602404882586508 0.9026847928237698 0.7174130496981308 1.0 13.983996545638815 -7.245341414016138 24.958750010108027 0.8369749691294287 0.8778214947274021 0.024816874953766166 0.0872731882017629 2782.821534036768 4314572.516455669 0.03147021269536512 0.024287335779437518 5.684059114768825e-08 7.245341414016138 0.040846525597973415 HECQANGPEDLNR ddPTM_A459_Selumetinib_30min_R1 2 HECQANGPEDLNR 13 0 P60981;P60981-2 P60981 DSTN Destrin 0 ; 219.97 1.8236e-08 116287000.0 4965.4 5585.4 5023.6 4860.3 5370.799999999999 4384.4 5167.5 5032.9 2755.7 3941.4 False True 5081.0841590134905 4931.458771417988 4341.422712659566 4011.5398441304674 4885.012088291757 4340.2969167166875 4777.71131462188 4899.411142836804 4676.221631635252 4447.317082487128 1.142505484716177 1.1088615180683514 0.9761891567739666 0.902013454342465 1.0984177646177304 0.9759360163025322 1.0742906849245797 1.1016554592273071 1.0514702560897933 1.0 12.118719553534937 -10.274514801900756 15.141049814498826 0.9999999999917473 1.04504068939546 0.03795681340605872 0.07106089623882099 0.0 0.0 0.07247379597454469 0.017577477405441872 5.3147788503064295e-11 10.274514801900756 0.04504068940371275 HECQANGPEDLNR ddPTM_A459_Selumetinib_30min_R2 4 HECQANGPEDLNR 13 0 P60981;P60981-2 P60981 DSTN Destrin 0 ;;; 124.51 0.0031537 98164000.0 72418.90000000001 61282.7 71689.8 72706.2 83858.0 59868.4 59200.6 61532.700000000004 58712.5 64529.0 False True 68394.14745382604 65982.88603506166 67077.35631795251 62803.49013480924 73323.00833996813 68114.72866877493 61953.54520376343 61711.74996971312 70456.64056431611 62665.88010352303 1.0914096688794606 1.0529316100892383 1.070396780626743 1.0021959323168985 1.170062691513144 1.0869508025140713 0.9886328110515191 0.9847743280357077 1.1243222060860372 1.0 15.935392527461095 -10.633938692246492 4.469285140007241 0.9999935171246178 1.0609110426333466 0.09990177531622968 0.056714504514072214 3.7484058479863602e-06 7.456468680308506e-07 0.05618519001043389 0.01362546000391309 2.323064711706138e-11 10.633938692246492 0.060917525508728754 HEDEQALLDQNSQT(ph)PPPSPFSVQAFNK ddPTM_A459_Selumetinib_30min_R1 1 HEDEQALLDQNSQTPPPSPFSVQAFNK 27 0 A0A499FJI4;O75592-2;O75592;A0A087WY34 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 HEDEQALLDQNS(0.012)QT(0.988)PPPSPFSVQAFNK 132.33 7.5722e-12 12152000.0 2271.3 2161.9 3032.9 3255.3 2630.0 2708.7 2394.5 2411.1 1210.1 1929.2 True False 2324.2168708195404 1908.7837429599583 2621.0488385271933 2686.8229645490856 2392.1169643642115 2681.4529373028217 2213.880937176989 2347.149795643431 2053.451317792874 2176.8316119993315 1.0677063205108648 0.8768632963790974 1.2040659571825432 1.2342814895458762 1.0988984867631306 1.2318145889290977 1.0170198397402126 1.078241322252606 0.943321158363215 1.0 11.088014097365402 -7.886864421994375 1.7906195913325857 0.9794495801265364 1.1132953282679166 0.20370209931694838 0.10284871496434032 0.6548076326127164 3.912644843599871 0.08896768220816192 0.03207720643676233 1.2975842874878822e-08 7.886864421994375 0.13384574814138017 HEDEQALLDQNSQT(ph)PPPSPFSVQAFNK ddPTM_A459_Selumetinib_30min_R2 4 HEDEQALLDQNSQTPPPSPFSVQAFNK 27 0 A0A499FJI4;O75592-2;O75592;A0A087WY34 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 HEDEQALLDQNS(0.043)QT(0.957)PPPSPFSVQAFNK;HEDEQALLDQNS(0.011)QT(0.989)PPPSPFSVQAFNK;HEDEQALLDQNSQT(0.985)PPPS(0.015)PFSVQAFNK;HEDEQALLDQNSQT(0.999)PPPS(0.001)PFSVQAFNK 174.25 3.7237e-22 30308500.0 100024.0 84597.0 105057.0 100079.0 114155.0 78720.0 71001.0 80000.0 67944.0 104634.0 True False 94465.06650779708 91085.31787777186 98297.74699741305 86448.06755409531 99813.82834135165 89562.96545098854 74302.68718581244 80232.7867552871 81534.69851397735 101612.9445482193 0.92965583201823 0.8963948272805767 0.967374259593146 0.8507584140824925 0.9822944191326539 0.8814129523476946 0.7312324971603684 0.789592183476324 0.8024046431927377 1.0 16.632724674243335 -7.009211568271281 24.0938558174357 0.8122803881906383 0.9228834154480644 0.25499590359171853 0.07340185801028364 304.3963784729356 796182.956756616 0.025001829169224693 0.020896457071099314 9.790129392025753e-08 7.009211568271281 0.1106030272574261 HEDGTQS(ph)DSEDPLAK ddPTM_A459_Selumetinib_30min_R2 2 HEDGTQSDSEDPLAK 15 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 HEDGTQS(0.999)DSEDPLAK;HEDGT(0.008)QS(0.992)DSEDPLAK 157.7 0.00010086 19295900.0 172248.0 164004.0 189647.0 187011.0 211552.0 164807.0 169131.0 170453.0 139681.0 160405.0 True False 162675.1457233766 176582.5794440235 177445.31849204103 161539.77918803057 184974.94646112435 187507.66828100962 176995.9266267185 170948.9900099868 167621.10301322964 155773.69086775847 1.0443043675550898 1.1335841017847512 1.139122514871143 1.0370158034270827 1.1874594832458314 1.203718466426986 1.1362376126593565 1.0974188841369314 1.0760552830164938 1.0 17.24909206688841 -8.545300574465855 1.5890705690030287 1.001320908898338 1.1275635576993757 0.3654938348257436 0.05020581022053929 0.475842538471169 2.6694434319431712 0.05011462282213152 0.014586942948065257 2.8490457653135654e-09 8.545300574465855 0.12624264880103775 HEDGTQSDS(ph)EDPLAK ddPTM_A459_Selumetinib_30min_R1 1 HEDGTQSDSEDPLAK 15 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 HEDGT(0.001)QS(0.088)DS(0.911)EDPLAK 101.3 0.0070303 5546200.0 1562.1 2214.3 2010.7 1791.6 1575.1 2081.3 2153.2 1605.7 955.73 1769.9 True False 1598.4938906825184 1955.048726599857 1737.6579839845126 1478.730692497202 1432.6324831064915 2060.364011669202 1990.7823904487352 1563.1116199513328 1621.8040062426107 1997.0839052859294 0.8004139868393043 0.978951721269791 0.8700976355501329 0.740444950051053 0.7173621895978259 1.0316862532494409 0.9968446419198937 0.7826970192960103 0.812086063059234 1.0 10.96367923196425 -6.759424793406859 24.999257831133576 0.915592710222877 0.8284058963050462 0.20485067326230877 0.10041550577428492 118.17211060263081 1466414.4420975177 0.03740927542523521 0.03564903238727704 1.7401040050290925e-07 6.759424793406859 -0.08718681391783079 HEDLVPPAGSPELS(ph)PPQPLFRPR ddPTM_A459_Selumetinib_30min_R2 1 HEDLVPPAGSPELSPPQPLFRPR 23 1 A0A0A0MQV9;Q9UPS6-2;Q9UPS6 A0A0A0MQV9 SETD1B Histone-lysine N-methyltransferase;Histone-lysine N-methyltransferase SETD1B 1 HEDLVPPAGS(0.019)PELS(0.981)PPQPLFRPR 70.11399999999999 0.0010925000000000002 1364200.0 13198.0 15321.0 16092.0 16484.0 15382.0 12728.0 10280.0 13964.0 10587.0 12084.0 True False 12464.507995780054 16496.071435220398 15056.658239644856 14238.850763513932 13449.575643175252 14481.166466719795 10758.040369433558 14004.63292813535 12704.695825495666 11735.103521997424 1.0621557766759673 1.4057031030274723 1.2830443473652522 1.2133553604212557 1.1460977415294253 1.2340041516953713 0.916740133503521 1.1933966242294922 1.0826232424520792 1.0 13.518542948297073 -6.721522888687348 1.2404131478679226 1.0681708913323682 1.258269064797815 0.334911699540413 0.11094875220447593 0.5176218918545559 1.6788996671650076 0.05282063123328594 0.04943550486183437 1.8987907672090901e-07 6.721522888687348 0.19009817346544677 HEEFEEGCK ddPTM_A459_Selumetinib_30min_R1 1 HEEFEEGCK 9 0 I3L3Q4;F6TLX2;Q9HC38-2;I3L1F4;Q9HC38-3 I3L3Q4 GLOD4 Glyoxalase domain-containing protein 4 0 98.048 0.028167 8541700.0 8599.1 9459.9 8791.6 8803.2 9785.0 8107.9 9247.4 8334.9 4604.5 7744.5 False True 8799.442299064112 8352.330510211805 7597.749008802029 7265.88637653012 8899.948477682057 8026.341887384188 8549.861172875544 8113.831376429198 7813.500200625804 8738.582012818177 1.0069645494150725 0.9557992930615288 0.869448727225685 0.8314720129504037 1.0184659781904182 0.9184947713039439 0.9784037227474883 0.9285066346607992 0.8941382239320501 1.0 13.093183480973385 -6.279572239808797 24.970808726243597 0.9519716452641426 0.915450107978272 0.10742053486309566 0.05622658468354343 2243.9065199747074 3090081.3816896896 0.018273841325886747 0.020757890609747653 5.253246262333448e-07 6.279572239808797 -0.0365215372858706 HEEQPAPGYDTHGR ddPTM_A459_Selumetinib_30min_R1 1 HEEQPAPGYDTHGR 14 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 145.61 0.00072164 2151300.0 778.98 1272.4 1176.6 1299.7 1124.0 1085.7 742.72 758.55 738.96 651.49 False True 797.1287183687781 1123.4268164772889 1016.8241826011717 1072.731793390607 1022.334398458318 1074.7788437367271 686.6960324326978 738.430789882346 1253.9611484970014 735.1150875499919 1.084359077740421 1.5282325658985874 1.3832176754663903 1.4592705435632285 1.3907133940966674 1.4620552100471427 0.934134047937084 1.0045104533813947 1.7058024923365827 1.0 9.521826321682747 -7.232025850486442 24.82441325803762 1.1614875261459745 1.3947718119920867 0.18611843254274807 0.22840608993072953 1062.0541821781997 896353.1463425211 0.08524654484789163 0.06602063968293233 5.861032768827765e-08 7.232025850486442 0.23328428584611216 HEEQPAPGYDTHGR ddPTM_A459_Selumetinib_30min_R2 1 HEEQPAPGYDTHGR 14 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 72.321 0.029439 4768000.0 8970.1 12127.0 11989.0 12505.0 13439.0 9675.4 10391.0 9267.5 9228.0 10696.0 False True 8471.577752155377 13057.101905549105 11217.640792636228 10801.79742767178 11750.672673815649 11008.098525463609 10874.202089375878 9294.466890682788 11073.85785186305 10387.17868845453 0.8155802462098427 1.2570402702383685 1.079950690085342 1.0399163961315214 1.1312670192991536 1.059777525315824 1.0468869762934452 0.8948018677115563 1.0661083422172923 1.0 13.342516229662486 -7.538517327599626 24.497740953317898 0.9824419052500174 1.0735598160351683 0.08606628461757515 0.10949907163438104 399.1810608972403 625304.9881203754 0.04847443073061718 0.027998177575428176 2.893894353375877e-08 7.538517327599626 0.09111791078515086 HEEQS(ph)NEDIPIAEQSSK ddPTM_A459_Selumetinib_30min_R1 1 HEEQSNEDIPIAEQSSK 17 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 HEEQS(1)NEDIPIAEQSSK 92.913 0.0090522 0.0 952.28 1546.1 833.75 1163.7 1267.1 928.74 1330.1 1463.6 725.48 1257.5 True False 974.4662711856789 1365.0818932376096 720.531329460927 960.4816403544276 1152.491028724675 919.3977188284501 1229.7694861303457 1424.7805735571826 1231.0865730372482 1418.9123740872694 0.6867698731660683 0.9620621527920025 0.5078053744681849 0.6769139926433214 0.8122355191003442 0.6479594762994879 0.8666986831525859 1.0041357025120652 0.867626920111369 1.0 10.470569782183759 -7.465609364370493 4.587011515602681 0.950534970668873 0.720836453597764 0.47583950287088495 0.11526420295303487 0.1967371820743704 8.547844735692966 0.05139217184910234 0.03271140495766302 3.4228718175129684e-08 7.465609364370493 -0.229698517071109 HEEQS(ph)NEDIPIAEQSSK ddPTM_A459_Selumetinib_30min_R2 1 HEEQSNEDIPIAEQSSK 17 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 HEEQS(1)NEDIPIAEQSSK 102.47 0.0056351000000000005 0.0 3846.3 4288.4 3127.4 5405.8 2561.1 2759.7 4909.9 3837.9 3831.8 4027.8 True False 3632.538043958844 4617.306490620662 2926.1864888556634 4669.520714474859 2239.3517214755 3139.823624937667 5138.220078782277 3849.0676536014503 4598.2670694374565 3911.5069485188064 0.9286799414569361 1.1804418479607008 0.7480969680914769 1.1937907246318697 0.572503577508277 0.8027145717142705 1.3136165028999878 0.9840370231373358 1.175574306771642 1.0 11.933508812478662 -7.245130801470012 24.98280181788035 1.1169767304676357 0.9078870936808543 0.2245763626757219 0.19467742785126005 1294.3268266897703 1982757.7429139 0.07409361276485611 0.057215295434254465 5.686816286541444e-08 7.245130801470012 -0.20908963678678139 HEERQDEHGYISR ddPTM_A459_Selumetinib_30min_R1 1 HEERQDEHGYISR 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 80.469 0.029476 2336700.0 389.89 375.03 2502.7 2528.0 880.37 658.03 275.12 232.4 285.68 124.35 False True 398.97367840612446 331.1213132532831 2162.847086347062 2086.53225643722 800.7406889419472 651.4108156434362 254.36747689961717 226.23599705841036 484.7780947583408 140.31153377157202 2.843484549571355 2.3599008887776147 15.414606541670263 14.87071091271874 5.706877171234958 4.642603484785055 1.8128764618433213 1.6123834654015248 3.4550124407275193 1.0 7.132489794820413 -6.758732241605402 2.515856908846323 2.2004154178033475 8.911315826026645 0.3504138325096703 4.084132937095056 0.35869949435456 4.655552954574432 1.728739535624098 1.6029534980108462 1.7428810919974366e-07 6.758732241605402 6.7109004082232975 HEGVFICR ddPTM_A459_Selumetinib_30min_R2 4 HEGVFICR 8 0 M0R2U2;M0R1H0;M0R2B0;M0R0P1;M0QXL5;M0R2Q4;P22087;M0R299 M0R2U2 FBL rRNA 2-O-methyltransferase fibrillarin 0 ;;; 134.81 0.0038113 7890500.0 55687.8 45364.8 54774.7 57020.1 60134.5 50861.1 50575.8 55235.6 51305.3 50521.1 False True 52592.89501192609 48844.134289177404 51250.55543618414 49253.8640148411 52579.866500749056 57866.7548539034 52927.67491404647 55396.326451254194 61567.793589855806 49062.42457341813 1.071958743767848 0.9955507644365583 1.044598914174974 1.0039019563971303 1.071693194087205 1.1794515936999868 1.0787822936643559 1.1290988354714893 1.2548868940980353 1.0 15.582330910501932 -6.547885015869268 5.797288115270925 1.1331885744801964 1.0286399284233032 0.34604175470272536 0.06444508686694388 0.1821199830971123 18.910526566594307 0.02034747534816974 0.0207828008569295 2.8321417365011537e-07 6.547885015869268 -0.10454864605689318 HEHPPNPPVS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 3 HEHPPNPPVSPGK 13 0 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 HEHPPNPPVS(1)PGK;HEHPPNPPVS(1)PGK;HEHPPNPPVS(1)PGK 119.04 0.0021862 33898900.0 131074.0 128980.0 129299.0 122475.0 132560.0 105143.0 138116.0 146687.0 101704.0 117892.0 True False 123789.43181079523 138872.35126393376 120980.04311010687 105793.69371884035 115906.62769856412 119625.49385687632 144538.6676716619 147113.8348846598 122047.64184719099 114488.15163979825 1.0812422948381646 1.2129844815807045 1.0567036097388782 0.9240580112751551 1.012389719271813 1.0448722609588557 1.262477082575395 1.2849699534630292 1.0660285811162045 1.0 16.80483877620898 -7.235357580461792 23.986812165417856 1.1771164075939662 1.0546766592909074 0.16223595819315118 0.10360806829282883 694.0671382300618 638317.7639660521 0.04140793871928975 0.032060163942630414 5.816241348467493e-08 7.235357580461792 -0.12243974830305882 HELIEFR ddPTM_A459_Selumetinib_30min_R1 2 HELIEFR 7 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 ; 168.45 4.6313e-05 12951700.0 8141.7 13441.2 7904.9 9276.3 7776.299999999999 9029.8 8367.8 6976.099999999999 3879.2 7005.400000000001 False True 8331.385769009581 11867.498055355642 6831.457998507572 7656.368342717003 7072.935038017275 8938.968410402415 7736.610109045568 6791.071166433635 6582.719074441879 7904.611328374512 1.0539905661272824 1.5013385936833974 0.8642370528687815 0.9685951686496701 0.8947859349678788 1.1308548945746337 0.9787464288438972 0.8591277779916014 0.832769481127105 1.0 12.94847881133022 -5.277517735127005 24.981696734988205 0.9435521496925197 1.2776646033238483 0.5184421101723141 0.12971659734153174 526.0765731736817 817389.6642759157 0.0328331991221973 0.0686928067093706 5.278156521241917e-06 5.277517735127005 0.3341124536313287 HELIEFR ddPTM_A459_Selumetinib_30min_R2 4 HELIEFR 7 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 ;;; 200.12 2.1535e-06 17442700.0 104425.0 98884.0 119153.0 112470.0 137069.0 94839.0 85083.0 99659.0 89050.0 109463.0 False True 98621.47654639582 106468.08483782626 111486.82570397742 97151.391978428 119849.16680759251 107902.21138727514 89039.52808876602 99948.99119056438 106862.48826489005 106302.51877097043 0.9277435538369182 1.0015574990016234 1.048769370593905 0.9139142995072524 1.1274348735405644 1.0150484921222915 0.8376050644726711 0.9402316365231687 1.0052676973264019 1.0 16.69781625545764 HELQANCYEEVK ddPTM_A459_Selumetinib_30min_R2 1 HELQANCYEEVK 12 0 P23528;G3V1A4;E9PP50;E9PK25 P23528 CFL1 Cofilin-1 0 84.29700000000003 0.046115 8672100.0 120960.0 85712.0 110600.0 109370.0 125150.0 92975.0 126870.0 114710.0 101100.0 108180.0 False True 114237.52744124523 92285.83479248144 103484.11641217527 94473.61732622643 109427.53814480455 105781.46230698259 132769.70638813564 115043.78710873713 121322.8249700208 105056.56231460485 1.087390686734512 0.8784395068641225 0.985032387622577 0.8992643129071131 1.0416059285959718 1.0069000924493126 1.2637926033648461 1.095065216052133 1.1548333802005115 1.0 16.680806756609996 -7.071300090560035 7.9967535066901245 1.136842179058099 0.9741275096412677 0.42423026505030803 0.08317743991543683 0.28003389194277645 28.717993008319816 0.030245052705069914 0.02346611759082424 8.485939075501475e-08 7.071300090560035 -0.16271466941683121 HELQANCYEEVKDR ddPTM_A459_Selumetinib_30min_R1 1 HELQANCYEEVKDR 14 1 P23528;G3V1A4;E9PP50;E9PK25 P23528 CFL1 Cofilin-1 0 238.2 9.8275e-18 7425600.0 1464.4 1662.3 1449.1 1437.0 1202.1 1193.9 1253.2 1445.8 811.7 1048.3 False True 1498.517670773626 1467.6771432176952 1252.3201793365283 1186.0549258308092 1093.3702672479922 1181.890449974467 1158.6701150428921 1407.4526873797327 1377.3956157776008 1182.8595163067062 1.2668602231417243 1.2407873656884356 1.0587226649253347 1.0027014277520294 0.9243449895570607 0.9991807426673415 0.9795500641197514 1.1898730728178808 1.164462556025506 1.0 10.208063025150745 -5.26294747730029 3.8585072675434686 1.0359014654182679 1.2615351521854885 0.5534191440630203 0.0772371654747605 0.17458453483098468 6.004640368375621 0.02309410816190863 0.06092646203513071 5.458238679387931e-06 5.26294747730029 0.22563368676722062 HELQANCYEEVKDR ddPTM_A459_Selumetinib_30min_R2 4 HELQANCYEEVKDR 14 1 P23528;G3V1A4;E9PP50;E9PK25 P23528 CFL1 Cofilin-1 0 ;;; 152.0 0.0011017000000000002 230522800.0 1057064.0 911333.0 901791.0 1007053.0 1026787.0 833089.0 936526.0 885213.0 753734.0 982016.0 False True 998316.6146424644 981229.3107025458 843770.7488558012 869890.6441366784 897792.8374677541 947839.4477210187 980076.3146910631 887788.8232750986 904501.8610875749 953662.6464960149 1.046823652274228 1.0289060962047927 0.884768583477624 0.9121576139454188 0.9414155422428048 0.9938938588017555 1.0276970774645504 0.9309254446916291 0.9484505494798726 1.0 19.863119484587266 -6.7665920464468385 24.99375378980471 0.9788452040279533 0.9593359315219882 0.02486617083048026 0.051847820803848844 652.7166578050817 3166083.3481620797 0.01999463590533179 0.01816363840283871 1.7116223688364369e-07 6.7665920464468385 -0.019509272505965125 HELS(ph)PPQKR ddPTM_A459_Selumetinib_30min_R2 1 HELSPPQKR 9 1 C9JUL9;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 C9JUL9;Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 1 HELS(1)PPQKR 96.113 0.039099 12554000.0 58039.0 46105.0 55180.0 57699.0 56801.0 52822.0 60927.0 60072.0 56049.0 50859.0 True False 54813.42472852545 49641.10524905928 51629.7788754414 49840.296663673245 49665.1505726172 60097.75102962548 63760.22622456017 60246.79957454504 67260.36613990819 49390.56852244848 1.1097953793265658 1.0050725621126821 1.045336800526505 1.0091055469632904 1.0055594025009842 1.2167859740733797 1.2909393054582992 1.2198037272472841 1.3618058700688518 1.0 15.591947954862212 -6.798046706557128 6.597605659451761 1.2375232813388646 1.032380963240776 0.49476447368923826 0.09138337394602024 0.1379354374255615 16.8217663537871 0.030022894776347783 0.026895742221801633 1.5920375008620211e-07 6.798046706557128 -0.20514231809808847 HEMLPASLIQAQR ddPTM_A459_Selumetinib_30min_R2 1 HEMLPASLIQAQR 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 123.26 0.0034966000000000003 3155200.0 43886.0 28683.0 38540.0 41729.0 42851.0 31203.0 34150.0 35621.0 23033.0 35000.0 False True 41446.99180957747 30882.89386961861 36060.37835917925 36045.43821345987 37467.674287199516 35500.930017367835 35738.04266694124 35724.65121262602 27640.243595791253 33989.45905907897 1.2194072208544464 0.9086020997256631 1.0609282806325546 1.0604887283085997 1.1023321736916987 1.044468814748175 1.0514448789791848 1.051050890528473 0.8132004556985802 1.0 15.052799781176187 -8.182202545791526 9.113834138673328 0.9070038336371672 1.0577091954976585 0.3620923739519799 0.08251326815435686 0.3729793221771032 40.29321862389731 0.051822144799678206 0.019501021111336673 6.573511911155922e-09 8.182202545791526 0.15070536186049133 HEQNIDCGGGYVK ddPTM_A459_Selumetinib_30min_R2 2 HEQNIDCGGGYVK 13 0 P27797 P27797 CALR Calreticulin 0 ; 168.89 0.00037696 18694900.0 152622.0 132636.0 158949.0 167292.0 168187.0 110277.0 131900.0 139572.0 111006.0 133198.0 False True 144139.88023427365 142808.754708041 148722.39439058586 144506.54100520347 147057.8454491431 125466.65575506432 138033.6113548918 139978.13141261158 133210.30176678658 129352.22765003434 1.1143208188439373 1.1040301145366713 1.1497474538510306 1.1171554106989907 1.136879110014338 0.9699613066928964 1.0671142960780324 1.08214704884191 1.0298261126757735 1.0 16.98094537416479 -6.735741031929618 24.9999987494798 1.0372754550104422 1.1242962374595324 0.6832306928983305 0.03201138194960375 143.78939692478409 139881.5455457851 0.010638245006519796 0.010634660030528159 1.8376337904230718e-07 6.735741031929618 0.08702078244909028 HERPAGPGT(ph)PPPDSGPLAK ddPTM_A459_Selumetinib_30min_R2 4 HERPAGPGTPPPDSGPLAK 19 1 H0YME5;Q9P2K8-2;Q9P2K8 H0YME5 EIF2AK4 Eukaryotic translation initiation factor 2-alpha kinase 4 1 HERPAGPGT(1)PPPDSGPLAK;HERPAGPGT(1)PPPDSGPLAK;HERPAGPGT(1)PPPDSGPLAK;HERPAGPGT(1)PPPDSGPLAK 92.633 0.0030564 52486700.0 230178.0 204859.0 224277.0 225559.0 237075.0 198977.0 201112.0 211417.0 148305.0 239110.0 True False 217385.62823554067 220571.02657449403 209847.26199433452 194837.4750890221 207291.51902260908 226384.2756166329 210464.10649586786 212032.18846803144 177970.14398792246 232206.2730176101 0.936174658033698 0.9498926265345394 0.9037105641776528 0.8390706786558086 0.8927042165087782 0.9749274757941803 0.90636701481319 0.9131199847126925 0.7664312495744916 1.0 17.825047421356714 -8.070209754943377 24.999939140877864 0.8687356960271021 0.9138710308268908 0.028192082865893142 0.06278701038331161 440.39593865626716 156810.04487475465 0.04075942418417551 0.015405621131428234 8.507270559951359e-09 8.070209754943377 0.04513533479978871 HEVSASTQS(ph)TPASSR ddPTM_A459_Selumetinib_30min_R2 2 HEVSASTQSTPASSR 15 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 HEVSASTQS(0.276)T(0.276)PAS(0.172)S(0.276)R;HEVSASTQS(0.722)T(0.276)PASS(0.002)R 152.01 0.00015564 13202900.0 19065.2 13026.9 22656.0 31496.0 26823.0 20086.9 23874.0 31317.0 21043.9 17376.3 True False 18005.632508042585 14026.021341914537 21198.337625987675 27206.19046636947 23453.25493933754 22853.688144276708 24984.188305433534 31408.127285191553 25253.268015693633 16874.60106995067 1.0670256697271494 0.8311912846870957 1.2562274828372961 1.6122568085367486 1.3898553715205608 1.3543246474118584 1.480579493516084 1.861266358534624 1.4965253347922527 1.0 14.042565775567327 -5.488902858848857 4.197417580120111 1.4851373614830685 0.9568737427644374 0.4703200866536307 0.2120056294191375 0.16569853426022013 6.49000970170549 0.0566190544289467 0.1174854917104046 3.244121723759764e-06 5.488902858848857 -0.5282636187186311 HEVSASTQST(ph)PASSR ddPTM_A459_Selumetinib_30min_R1 2 HEVSASTQSTPASSR 15 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 HEVSAS(0.002)T(0.002)QS(0.296)T(0.701)PASSR;HEVSASTQS(0.026)T(0.973)PASSR 206.67 4.671e-06 6933000.0 1765.88 2607.29 1634.87 1861.13 1973.52 1703.3 2888.8 2157.42 964.34 1603.54 True False 1807.0215681956624 2302.0272747037634 1412.863633698094 1536.1185832369479 1795.0154644532558 1686.1663484726614 2670.8954902137784 2100.1982133122024 1636.4145473930919 1809.369978802306 0.9987020838003524 1.2722811263993488 0.7808594429279326 0.8489798113339794 0.9920665676355745 0.9319079946207586 1.4761466817205349 1.160734530757721 0.9044112406884853 1.0 10.821271724134496 HFAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 HFASPSK 7 0 A0A1X7SBT5;Q92664 A0A1X7SBT5 GTF3A Transcription factor IIIA 1 HFAS(0.997)PS(0.003)K 90.601 0.019471 5535400.0 58089.0 56641.0 49932.0 48612.0 55617.0 43745.0 67065.0 106440.0 56871.0 125880.0 True False 54860.64592869133 60985.18257047968 46719.42948185103 41990.96173962257 48629.895237711506 49770.47667242752 70183.65538677643 106749.72277790947 68246.78910850707 122245.5173244815 0.4487742956093218 0.4988745919296501 0.382177036053123 0.3434969449895179 0.39780514085135 0.407135392460401 0.5741204824753202 0.8732403863493753 0.558276414564607 1.0 16.899422037754917 -7.532362136744039 3.2635925300376103 0.7866596973878323 0.41298651926127355 0.7188689427611114 0.1105667521352813 0.1329235606489852 2.9542201279881697 0.05356743059100967 0.030395650755701262 2.9352011118358548e-08 7.532362136744039 -0.3736731781265587 HFDETVNR ddPTM_A459_Selumetinib_30min_R2 2 HFDETVNR 8 0 B7Z4L4;P04843 B7Z4L4 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 ; 175.38 1.1614e-12 1977400.0 7412.0 2489.66 6974.1 9352.7 4742.0 4415.8 10313.0 7040.7 7104.8 6783.9 False True 7000.070712586892 2680.608916481354 6525.393998825948 8078.846125692596 4146.267565982128 5024.036367358683 10792.574934821812 7061.187271349366 8525.958524698377 6588.031180311016 1.0625436524203615 0.40689074521878693 0.9904922761033272 1.2262914222138213 0.6293636827909466 0.7626005751723691 1.6382094497482786 1.0718205603598876 1.2941587997001363 1.0 12.68563166783407 -7.229231886443329 24.942342329538715 1.257032392055933 0.8403447395179541 0.3572978230274042 0.2657733131648896 695.2502162984601 538421.0002218612 0.1007764969689229 0.07805498931794405 5.8988603334477974e-08 7.229231886443329 -0.4166876525379789 HFEALANR ddPTM_A459_Selumetinib_30min_R2 1 HFEALANR 8 0 F5H365;Q15436-2;Q15436 F5H365 SEC23A Protein transport protein Sec23A 0 122.74 0.0087866 2106400.0 5475.9 4289.6 6053.6 5977.9 6121.1 5449.3 4589.5 4065.5 5271.1 3974.2 False True 5171.5713997645125 4618.598526762055 5664.117966661327 5163.699707547309 5352.112694671695 6199.891611179775 4802.920843921723 4077.3299319202415 6325.467286839544 3859.4545197883326 1.3399746967475967 1.1966972283470145 1.4675954691576387 1.3379351100192538 1.3867536635631155 1.6064165491240978 1.2444558730504574 1.0564523849198924 1.638953705609791 1.0 11.914181241687388 -10.697591779722748 4.316381972821992 0.9999201323536455 1.356529715258301 0.29459249474051874 0.16859093432027591 118940501.92286235 21.282422768359844 115474.47090416656 0.04018272615325887 2.006357040532244e-11 10.697591779722748 0.3566095829046554 HFEASCGQLS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 4 HFEASCGQLSPAR 13 0 A0A1B0GV70;Q96N21-2;Q96N21 A0A1B0GV70 ENTHD2 AP-4 complex accessory subunit tepsin 1 HFEASCGQLS(1)PAR;HFEAS(0.062)CGQLS(0.938)PAR;HFEASCGQLS(1)PAR;HFEASCGQLS(1)PAR 158.31 0.00036465 35271100.0 2564.24 2724.1099999999997 2822.8099999999995 3232.6800000000003 2455.9700000000003 2399.98 2856.88 2701.2200000000003 1377.48 2216.0299999999997 True False 2623.9818028575255 2405.1699347956187 2439.487906585429 2668.153122919095 2233.8279471367214 2375.83838020749 2641.383241512716 2629.5748708008578 2337.482952841357 2500.479036460126 1.0493916423999459 0.9618836629802607 0.9756082218705417 1.0670567855255215 0.8933599980502549 0.9501532888557679 1.0563508843697667 1.0516284409740504 0.9348140571298215 1.0 11.2879887944779 -7.250575574711011 24.848152158697747 1.0150007180392946 0.9813758877903183 0.0541925468083464 0.05550546787179776 1953.0840143541266 4467181.813132222 0.021618771064632118 0.016572566366614687 5.615965423925059e-08 7.250575574711011 -0.033624830248976334 HFEASCGQLS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 3 HFEASCGQLSPAR 13 0 A0A1B0GV70;Q96N21-2;Q96N21 A0A1B0GV70 ENTHD2 AP-4 complex accessory subunit tepsin 1 HFEASCGQLS(1)PAR;HFEASCGQLS(1)PAR;HFEASCGQLS(1)PAR 161.49 0.00036364 32479900.0 61819.5 64449.4 64243.5 76658.5 88421.7 66778.1 54589.9 58635.1 53934.3 71641.4 True False 58383.819673066 69392.46174251642 60110.14315303405 66217.4800567116 77313.37554597248 75976.17712376341 57128.43851783471 58805.718433436625 64722.66705025327 69572.92663528859 0.8391744101713944 0.9974061046228773 0.8639875603931422 0.9517708002113131 1.1112566235895243 1.0920365262488034 0.8211303057194977 0.8452385328233317 0.9302852442809962 1.0 16.086238389537407 -4.0646043667318335 0.0024414125917741718 1.8767074478906571 5.673731984842407e-06 0.010808745383890206 0.09863534176988337 2301148.612067615 720.6527233480249 271010.12703521515 283056.42818885535 8.617784570112741e-05 4.0646043667318335 -1.8767017741586722 HFEELETIMDR ddPTM_A459_Selumetinib_30min_R1 1 HFEELETIMDR 11 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 95.477 0.029764 5943300.0 2859.8 3446.4 3102.4 3376.9 3694.2 3347.9 3349.9 3473.9 2022.6 3083.6 False True 2926.4277757978784 3042.8938858121087 2681.1111202633674 2787.1878072637846 3360.0602622639844 3314.223165649987 3097.214345980036 3381.7608871824946 3432.204475140787 3479.4100968075545 0.8410700936009092 0.8745430406734865 0.7705648502668179 0.8010518247967088 0.9656982559621021 0.9525244433505753 0.8901550147313211 0.9719351249469973 0.9864328663901735 1.0 11.764627015290602 -6.264277250965554 24.999193039735093 0.9557425889960003 0.8219140912501414 0.7710162528867519 0.03712512786419122 129.92438800737668 1144520.0237227113 0.011984620150289811 0.014207863856077179 5.441551565799236e-07 6.264277250965554 -0.13382849774585892 HFELGGDK ddPTM_A459_Selumetinib_30min_R2 4 HFELGGDK 8 0 R4GN19;H0Y5B4;H7BZ11;J3KQN4;Q969Q0;P83881 R4GN19 RPL36A;RPL36A-HNRNPH2;RPL36AL 60S ribosomal protein L36a-like;60S ribosomal protein L36a 0 ;;; 115.71 0.013638 25425900.0 469550.0 416148.0 472100.0 466293.0 496251.0 391157.0 433125.0 432307.0 348512.0 421518.0 False True 443454.29075757856 448065.2134732793 441725.5999836148 402783.0889997086 433907.5128397711 445035.3261802892 453266.170720906 433564.9417977238 418224.1382388909 409347.68010471034 1.0833194184565644 1.0945834928358824 1.0790963805404303 0.9839632873861102 1.0599974885133792 1.0871817474730772 1.1072889691348964 1.059160617905099 1.0216843982892734 1.0 18.642967193610467 -8.337600885461475 2.9091218252986133 1.0020977447556967 1.069635086852529 0.36244325942503375 0.03181251834283172 0.31138653365488583 4.885277407949919 0.03288198648513971 0.009050884166002384 4.596202075682053e-09 8.337600885461475 0.06753734209683238 HFGAEYR ddPTM_A459_Selumetinib_30min_R2 2 HFGAEYR 7 0 P04818-2;P04818 P04818-2 TYMS Thymidylate synthase 0 ; 120.65 0.018335 2047500.0 1089.16 765.91 648.76 1218.82 1457.69 533.91 692.51 0.0 1215.0 1767.1299999999999 False True 1028.6288474529335 824.652834211191 607.01948791648 1052.8146134182264 1274.5619502860582 607.4512561475779 724.7130871825321 0.0 1458.0339499364552 1716.1083653448634 0.5993962084359538 0.4805365738342937 0.3537186230046116 0.6134895876500528 0.7427048174955586 0.3539702203045357 0.4223003056318627 0.0 0.8496164807421434 1.0 10.744924940768469 -8.505286392408054 23.90370277019878 1.0000001191569807 0.45358388174356057 0.5137476030189113 0.1891458124999238 291.67628199733406 396316.5743963412 0.18722099202905923 0.04834025226947277 3.1240185758749384e-09 8.505286392408054 -0.5464162374134202 HFIDVGAGVIDEDYR ddPTM_A459_Selumetinib_30min_R1 3 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNJ9;A0A0C4DGL3;H0YKC5;H0YMP1;P33316;H0YKI0;H0YNW5;H0YMM5 P33316-2;P33316;H0YNW5 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 ;; 141.0 0.00054406 14489400.0 8355.0 10815.3 9205.4 9205.1 9244.8 9209.4 9246.0 8700.1 4941.34 8438.5 False True 8549.65524400002 9549.039648103439 7955.357241642725 7597.602086127481 8408.609472302005 9116.761797466163 8548.566776002697 8469.345086092408 8385.093078805585 9521.663672950632 0.8979161139967675 1.0028751251979817 0.8355007606751006 0.7979280036650453 0.8831029703547902 0.9574757217444338 0.8978017991002631 0.8894816470101043 0.8806331925613122 1.0 13.216997955151 -6.596280493716494 24.999976988361055 0.9168912940133053 0.8826270197899446 0.10216322817931156 0.05922218458820125 131.50603430798262 44785.99585222103 0.02087394627293816 0.020873946779175964 2.533491819304948e-07 6.596280493716494 -0.03426427422336065 HFILDECDK ddPTM_A459_Selumetinib_30min_R2 2 HFILDECDK 9 0 Q13838;Q13838-2;F6S4E6;A0A0A0MT12;F6TRA5;F6WLT2;A0A0G2JJZ9;Q5STU3;A0A140T9L4;A0A140T973;A0A140T9K1;A0A140T9X9;A0A140T996;F6UJC5;A0A140TA18;A0A140T9X3 Q13838 DDX39B Spliceosome RNA helicase DDX39B 0 ; 123.35 0.0079431 11612900.0 135544.0 123206.0 140247.0 137023.0 143629.0 109505.0 131848.0 147080.0 115073.0 131362.0 False True 128011.00710562286 132655.5040302701 131223.66070938786 118360.23102214055 125585.04096044846 124588.31976258261 137979.1932518556 147507.9784495951 138090.81540826138 127569.23774053507 1.0034629772264243 1.0398706332327552 1.02864658465927 0.927811697541653 0.984446118709886 0.9766329404271006 1.0816023964374037 1.1562974041564293 1.0824773891737622 1.0 16.960920951582324 -7.313934711804888 5.984445559215083 1.0941957146550236 0.9938131892484466 0.449659560721391 0.04597172628701981 0.18487404061276907 15.366388956458822 0.019729694802634038 0.013301495602840895 4.853614598547912e-08 7.313934711804888 -0.100382525406577 HFKDEDEDEDVAS(ph)PDGLGR ddPTM_A459_Selumetinib_30min_R2 3 HFKDEDEDEDVASPDGLGR 19 1 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 HFKDEDEDEDVAS(1)PDGLGR;HFKDEDEDEDVAS(1)PDGLGR;HFKDEDEDEDVAS(1)PDGLGR 154.81 2.91e-06 53923500.0 173086.0 138718.0 156935.0 158449.0 107736.0 131489.0 168948.0 165161.0 107400.0 133512.0 True False 163466.57303815632 149357.2245513285 146837.97295790893 136867.97286022888 94201.2405079398 149600.4162117001 176804.4167641111 165641.59116612456 128883.0010067283 129657.16165416405 1.2607600764404552 1.1519396433319327 1.1325095435111516 1.0556144459285504 0.7265409739510093 1.1538152949139122 1.3636301651867364 1.2775352248412022 0.9940291717205666 1.0 16.9843423705439 -6.98481206519914 24.999299479828554 1.1928975606698335 1.0601257392130587 0.0560916813143042 0.1668213877926348 551.3487380456893 907515.5432190944 0.06182442413685258 0.05450644348076644 1.0355902067608782e-07 6.98481206519914 -0.1327718214567748 HFLPLDFSTQVNS(ph)SLTSPTGR ddPTM_A459_Selumetinib_30min_R2 1 HFLPLDFSTQVNSSLTSPTGR 21 0 P19793 P19793 RXRA Retinoic acid receptor RXR-alpha 1 HFLPLDFSTQVNS(0.607)S(0.225)LT(0.085)S(0.06)PT(0.023)GR 73.839 0.0023283 3899100.0 20299.0 18601.0 19120.0 24544.0 25196.0 15387.0 14284.0 15841.0 16540.0 19629.0 True False 19170.862843335304 20027.636888358113 17889.840016281985 21201.064859238395 22030.65322490208 17506.419580721045 14948.234303209047 15887.094687381274 19848.46216621314 19062.259767733158 1.005697282322528 1.0506433724221436 0.9384952379341857 1.1122010253540668 1.155720963481651 0.9183811255344607 0.7841795508689922 0.8334318638482457 1.0412439242807294 1.0 14.218431535652195 -6.909507095904813 8.349145299890704 0.893878122716456 1.0490740809852381 0.36634237775389644 0.088406960928788 0.2645672799111472 21.59902510978844 0.03206771874470782 0.028282026160832918 1.2316658614762555e-07 6.909507095904813 0.15519595826878219 HFLPLDFSTQVNSSLTS(ph)PTGR ddPTM_A459_Selumetinib_30min_R1 1 HFLPLDFSTQVNSSLTSPTGR 21 0 P19793 P19793 RXRA Retinoic acid receptor RXR-alpha 1 HFLPLDFSTQVNS(0.001)S(0.007)LT(0.209)S(0.658)PT(0.125)GR 132.39 3.0828000000000004e-05 11672000.0 2340.5 2596.4 2939.7 2825.7 2864.2 2736.4 2387.2 2424.3 1449.4 2159.3 True False 2395.0290961797787 2292.412280966388 2540.5048866162374 2332.2445399583285 2605.1336157155797 2708.8743004524113 2207.1315820542536 2359.9996887637885 2459.5259400123887 2436.4671883631327 0.982992550697474 0.940875498720127 1.042700225453477 0.9572238653971683 1.0692258152122953 1.1118041373141936 0.9058737144484382 0.9686154199143078 1.0094640107444859 1.0 11.250575078706975 -5.250138577165563 24.88968924707905 1.007409447710088 0.9619340254388422 0.09835141502127953 0.055896398573990376 1807.5200262139567 3980989.3051033383 0.014955254351328733 0.038753665740192664 5.6216191873069985e-06 5.250138577165563 -0.04547542227124568 HFLPLDFSTQVNSSLTS(ph)PTGR ddPTM_A459_Selumetinib_30min_R2 1 HFLPLDFSTQVNSSLTSPTGR 21 0 P19793 P19793 RXRA Retinoic acid receptor RXR-alpha 1 HFLPLDFST(0.002)QVNS(0.025)S(0.065)LT(0.176)S(0.479)PT(0.253)GR 75.43 0.012963 0.0 10221.0 10735.0 12472.0 12175.0 16725.0 10906.0 9523.2 12082.0 9925.5 13766.0 True False 9652.957737904833 11558.339981534557 11669.565098486868 10516.743996953532 14623.855976602925 12408.20250518904 9966.047669862808 12117.156619717227 11910.877341641386 13368.539811636598 0.7220652273109477 0.8645925541900725 0.8729124693430719 0.7866785860785835 1.0939007687192315 0.9281643829484177 0.745485132279585 0.9063934274384919 0.8909632248148451 1.0 13.706554274183837 -3.8917474966460963 0.9844232911054218 0.9032782415660675 3.158321374273506e-15 0.2621359076356151 0.09224124845558247 14.523403877995413 3.075122740503145 0.03055487257633687 21.09970731094604 0.00012830763598485197 3.8917474966460963 -0.9032782415660644 HFNYPST(ph)PPSER ddPTM_A459_Selumetinib_30min_R2 1 HFNYPSTPPSER 12 0 Q9BX63;Q9BX63-2 Q9BX63 BRIP1 Fanconi anemia group J protein 1 HFNYPS(0.049)T(0.861)PPS(0.091)ER 95.755 0.024059 5806800.0 28401.0 25476.0 28775.0 29454.0 35482.0 28215.0 25858.0 26280.0 24551.0 29699.0 True False 26822.58611821105 27429.92728174891 26923.647827851153 25442.31438901596 31024.43394689534 32101.36013973123 27060.44823665496 26356.47044911179 29461.88601225504 28841.512702731026 0.9299992824464854 0.9510571641809741 0.9335033188221689 0.8821421626268169 1.075686780602101 1.1130262296086684 0.9382464961379291 0.9138380056818612 1.0215097354954363 1.0 14.815859213736232 -6.251050779538747 24.987618931162363 1.007601625171031 0.9267618781058968 0.35524594035948565 0.05678029541871517 972.718930687409 2339673.6842217734 0.01882664639479863 0.02402635162892178 5.609823797766614e-07 6.251050779538747 -0.08083974706513408 HFS(ph)QEPR ddPTM_A459_Selumetinib_30min_R2 1 HFSQEPR 7 0 Q9Y4G2 Q9Y4G2 PLEKHM1 Pleckstrin homology domain-containing family M member 1 1 HFS(1)QEPR 94.309 0.016249 2841900.0 5429.6 2539.0 5770.4 2216.4 6811.3 2283.1 4824.2 2670.2 6008.6 4712.8 True False 5127.844568410925 2733.7331358282495 5399.138746336483 1914.5224964967392 5955.603600205407 2597.5763010817063 5048.534858970948 2677.9698399245917 7210.487894311261 4576.729218675063 1.1204168574114173 0.597311530835912 1.1796937263200165 0.4183167508981409 1.3012794324610535 0.5675617186357576 1.1030879516250844 0.5851274375152674 1.575467446247269 1.0 12.160101222344395 -8.260356672696476 24.999959956953695 1.287733705420122 0.8595212473953443 0.22464842726869927 0.31852490838803943 127.47547639123174 2943633.2083080397 0.21779464361587558 0.07161903928018305 5.4908973812241546e-09 8.260356672696476 -0.4282124580247778 HFS(ph)QSEETGNEVFGALNEEQPLPR ddPTM_A459_Selumetinib_30min_R2 1 HFSQSEETGNEVFGALNEEQPLPR 24 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 HFS(0.674)QS(0.326)EETGNEVFGALNEEQPLPR 139.64 3.2748e-08 3125600.0 4922.4 5291.2 7260.3 9195.7 12464.0 4722.2 4596.4 6464.0 4455.9 6106.1 True False 4648.832713928458 5697.018026110448 6793.180202416948 7943.229796532702 10898.160890426236 5372.64018613641 4810.141707593811 6482.809169827197 5347.2045082484365 5929.801027446915 0.7839778590227032 0.9607435392420423 1.145600024515791 1.3395440689774158 1.8378628287833894 0.9060405503099331 0.8111809629580142 1.093259139694672 0.9017510846482286 1.0 12.53376798108065 HFSQS(ph)EETGNEVFGALNEEQPLPR ddPTM_A459_Selumetinib_30min_R1 2 HFSQSEETGNEVFGALNEEQPLPR 24 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 HFS(0.439)QS(0.561)EETGNEVFGALNEEQPLPR;HFS(0.429)QS(0.571)EETGNEVFGALNEEQPLPR 203.73 2.5698e-31 53818000.0 2074.4700000000003 2621.5 2717.0 2648.4 2505.2 2041.54 2326.6000000000004 2540.8 1234.9299999999998 1728.25 True False 2122.8011147840507 2314.5735612977146 2348.0463234127005 2185.9066566251336 2278.6051023289824 2021.003961170009 2151.102688843595 2473.409730318456 2095.5860142814263 1950.087722080574 1.0885669863708525 1.1869074068259176 1.2040721536913936 1.1209273469467114 1.1684628729921487 1.03636566616284 1.1030799612176192 1.2683581883585948 1.0746111523873492 1.0 10.929323307798049 HFSQS(ph)EETGNEVFGALNEEQPLPR ddPTM_A459_Selumetinib_30min_R2 3 HFSQSEETGNEVFGALNEEQPLPR 24 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 HFS(0.144)QS(0.856)EETGNEVFGALNEEQPLPR;HFS(0.197)QS(0.788)EET(0.015)GNEVFGALNEEQPLPR;HFS(0.06)QS(0.925)EET(0.015)GNEVFGALNEEQPLPR 129.93 7.8902e-08 38408900.0 10024.8 10134.5 12599.1 14707.300000000001 16394.7 13519.2 10543.0 13539.8 8011.6 11870.4 True False 9467.661748453998 10911.783562446386 11788.487622862882 12704.140368492383 14335.051215522386 15381.347084921306 11033.270390558175 13579.19857636545 9614.14386280733 11527.670708996879 0.8212987677610251 0.9465731488955685 1.0226252918260794 1.1020561472646262 1.243534064894347 1.3342979230762368 0.957111863192549 1.1779655161183116 0.8340057679912631 1.0 13.492813409792864 -5.125776140874463 1.5857891408320954 1.109011427948889 0.8081299618574507 0.27878874638340745 0.13654891061075802 0.7330164949105843 2.743947261233861 0.04044820540735011 0.2790571593173615 7.485552473946381e-06 5.125776140874463 -0.3008814660914383 HGAGS(ph)GCLGTMEVK ddPTM_A459_Selumetinib_30min_R1 3 HGAGSGCLGTMEVK 14 0 Q9BYG5-2;Q9BYG5 Q9BYG5-2 PARD6B Partitioning defective 6 homolog beta 1 HGAGS(0.993)GCLGT(0.007)MEVK;HGAGS(0.907)GCLGT(0.093)MEVK;HGAGS(1)GCLGTMEVK 167.61 0.00021128 24764800.0 4541.82 4885.150000000001 5446.3 5568.7 4636.799999999999 4632.21 4574.0 4428.02 2761.0 3893.6499999999996 True False 4647.635569156695 4313.19436695538 4706.722374384467 4596.231082445391 4217.402258693528 4585.614173110164 4228.979497451471 4310.57452536395 4685.2153445385675 4393.437904862741 1.057858485723129 0.9817355930264667 1.0713073625497191 1.0461581981978612 0.9599321419851244 1.0437416602689933 0.9625672625919569 0.9811392851581956 1.0664121004994476 1.0 12.101134588255773 -6.208199686203032 24.99979694573658 1.0014411617849535 1.0374444356124057 0.18466765389902384 0.03794972591804985 586.019978941428 275177.5472696715 0.010909744092259718 0.014084388029883599 6.1915632496154e-07 6.208199686203032 0.036003273827452276 HGAGS(ph)GCLGTMEVK ddPTM_A459_Selumetinib_30min_R2 3 HGAGSGCLGTMEVK 14 0 Q9BYG5-2;Q9BYG5 Q9BYG5-2 PARD6B Partitioning defective 6 homolog beta 1 HGAGS(1)GCLGTMEVK;HGAGS(0.999)GCLGT(0.001)MEVK;HGAGS(1)GCLGTMEVK 138.81 0.00038085 37964800.0 190565.0 178436.0 194444.0 215869.0 208093.0 157156.0 199166.0 195918.0 157887.0 171136.0 True False 179974.16019213735 192121.46743782988 181933.6847346201 186467.26980520444 181950.49696497645 178802.8124798727 208427.6136399418 196488.0889440289 189468.8117313719 166194.8590152725 1.082910513950366 1.1560012660811299 1.0947010383630535 1.1219797706743084 1.0948021981128555 1.075862475766724 1.2541158906773904 1.1822753730665796 1.1400401483776381 1.0 17.342516229662486 HGAPAAPS(ph)PPPR ddPTM_A459_Selumetinib_30min_R1 4 HGAPAAPSPPPR 12 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 HGAPAAPS(1)PPPR;HGAPAAPS(1)PPPR;HGAPAAPS(1)PPPR;HGAPAAPS(1)PPPR 114.76 0.0054215 38127100.0 10030.9 10850.0 12717.599999999999 13307.1 12548.2 10682.2 11039.2 10015.900000000001 5867.7 9133.0 True False 10264.600453266296 9579.676955971845 10990.619772776354 10983.264790204019 11413.217525564645 10574.74676666158 10206.50425628909 9750.245795771654 9957.058340148124 10305.309512953505 0.996049700434903 0.9295865343908828 1.06650069645763 1.065786988386748 1.1075084655359966 1.0261454790241282 0.9904121990183585 0.9461380838213399 0.9662066265581214 1.0 13.331100215440436 -10.171392592289259 6.6769097609327925 0.99999926934711 1.0122083167257157 0.00246641281648341 0.05398023816979398 0.0 0.0 0.05873533228176845 0.014245410526675419 6.739185452925011e-11 10.171392592289259 0.01220904737860562 HGAPAAPS(ph)PPPR ddPTM_A459_Selumetinib_30min_R2 2 HGAPAAPSPPPR 12 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 HGAPAAPS(1)PPPR;HGAPAAPS(1)PPPR 94.402 0.018988 14256500.0 16838.2 15273.4 15843.7 19059.4 22591.0 12405.099999999999 15045.900000000001 17283.9 9445.9 13209.099999999999 True False 15902.40025265524 16444.820668278517 14824.333591316261 16463.47684070113 19752.91661389756 14113.78992271415 15745.564162885245 17334.193287496324 11335.343940497742 12827.71896163656 1.2396904157484296 1.2819754406422144 1.1556484543862329 1.2834298046237147 1.5398619717949826 1.100257182506399 1.2274640729170159 1.3513075348265058 0.8836601405439256 1.0 13.646977031246864 -8.263790283852398 24.98368092916876 0.9418300351152779 1.2709180545161252 0.5715135003416945 0.11450556522407912 152.43779801589264 1619941.4336756014 0.09497592842761265 0.029025686780661978 5.4476565082815535e-09 8.263790283852398 0.3290880194008473 HGAPS(ph)PSHPISAPQAAAAAALR ddPTM_A459_Selumetinib_30min_R2 2 HGAPSPSHPISAPQAAAAAALR 22 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;H0YF36 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 HGAPS(0.482)PS(0.482)HPIS(0.036)APQAAAAAALR;HGAPS(0.492)PS(0.492)HPIS(0.015)APQAAAAAALR 73.918 0.0011021 14736500.0 24242.0 24194.0 35072.0 38136.0 41543.0 32939.0 39630.0 32248.0 28438.0 34650.0 True False 22894.726688414932 26049.602004028624 32815.50570350637 32941.8110117306 36323.99694086787 37476.04825952888 41472.87352535524 32341.83634105621 34126.394624109394 33649.56446848814 0.680387013919755 0.7741438088574173 0.9752133860227867 0.9789669355922769 1.079478962495466 1.1137157003807323 1.232493620064337 0.9611368483340526 1.0141704703508954 1.0 15.03830021148107 -5.178450299530163 1.170437695064468 1.0725743563591128 0.6119241570746504 0.7658256067396377 0.07268595497976958 0.4249490644714483 0.772014814306752 0.024932348147312967 0.20246439084543646 6.630552230776331e-06 5.178450299530163 -0.4606501992844624 HGDPGDAAQQEAK ddPTM_A459_Selumetinib_30min_R2 1 HGDPGDAAQQEAK 13 0 O14737;Q3HM38;X6R2P6;K7ESJ4;O14737-2 O14737 PDCD5 Programmed cell death protein 5 0 135.02 0.0016430999999999998 10480000.0 61084.0 66716.0 62663.0 64414.0 64897.0 47533.0 54027.0 45860.0 40185.0 61296.0 False True 57689.19581862621 71832.90267424878 58631.330802315795 55640.70207965211 56744.058673458865 54080.23928838718 56539.36255246951 45993.44500746833 48223.12286271314 59526.22521386579 0.9691391586038002 1.2067437909285792 0.9849663840041121 0.9347258604043214 0.9532614989374656 0.9085111493982312 0.9498227436618888 0.7726585188666525 0.8101155866923718 1.0 15.861237789993012 -5.934721446791182 0.8692981124602432 0.8710327241302572 1.0961349758289116 0.4047874327288342 0.08555626360389149 0.6464426957464667 0.9606596497853417 0.039157309253667325 0.09964358463471001 1.1621937971831168e-06 5.934721446791182 0.2251022516986544 HGENEHNLQGR ddPTM_A459_Selumetinib_30min_R2 2 HGENEHNLQGR 11 0 Q5W015;Q5VX20;A0A1W2PR17;Q16875-3;Q16875-2;Q16875;Q16875-4;F2Z2I2 Q5W015 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 0 ; 133.91 0.00097569 2023660.0 4565.2 2824.8 1820.42 2690.0 1759.94 2360.4 6206.5 6521.7 2637.39 7126.5 False True 4311.484459943561 3041.4530768364093 1703.2961591234332 2323.617359491171 1538.8406031367738 2685.5236744221743 6495.114547946434 6540.677067274445 3164.9416948336666 6920.73942812932 0.6229803194756254 0.4394693816204717 0.2461147651651776 0.3357469795852791 0.22235205054566307 0.3880399923029717 0.9385000859224759 0.9450835615468901 0.45731265101092705 1.0 12.756710471701133 -7.250400109060212 22.861263780500607 0.8306476917639872 0.36399052540330945 0.6269525528221713 0.17346238195864777 149.75703969150948 310132.874078922 0.06731173711575585 0.05152159257442681 5.618234870488605e-08 7.250400109060212 -0.4666571663606778 HGESAWNLENR ddPTM_A459_Selumetinib_30min_R1 2 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 ; 147.62 0.00093186 50088000.0 11938.3 12314.5 11292.400000000001 12049.1 11390.4 9743.1 10986.7 10371.7 5405.4 7928.6 False True 12216.439162111965 10872.712615144266 9758.954104713137 9944.950874619346 10360.140331138455 9645.093260027003 10157.964373557086 10096.608823970373 9172.569005204194 8946.313041104033 1.3655277996626392 1.215328880756726 1.090835303870478 1.111625630461068 1.1580346320924118 1.0781081788343878 1.1354358300325613 1.128577636125774 1.0252904143931274 1.0 13.127077525337139 -4.8585528023865825 1.9368574810233852 1.0987381431558778 1.4229524442105879 0.7707454668907618 0.04691132633110589 0.2964751244137661 1.3704818149782967 0.012236268174548601 0.16549945052213685 1.3849917856324833e-05 4.8585528023865825 0.32421430105471005 HGESAWNLENR ddPTM_A459_Selumetinib_30min_R2 4 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 ;;; 184.44 3.5313e-05 91505800.0 403172.0 341115.0 418463.0 441669.0 523628.0 366986.0 371158.0 381383.0 292971.0 419924.0 False True 380765.3142653918 367277.42364239914 391539.5461680646 381512.92027847783 457845.169346286 417534.9903327811 388417.5824356249 382492.7613886452 351573.38629368896 407799.7030264185 0.9337066982629083 0.90063190560638 0.9601270998049242 0.9355399659370577 1.1227207031992992 1.0238727179890366 0.9524714695794225 0.9379427168534896 0.8621227129018114 1.0 18.63750119917222 -1.7112330539232916 14.989257824203037 0.9644642930381268 0.004811364115562822 0.0 0.06858155064530198 0.0 0.0 0.016881940906721155 0.0 0.019443164299216047 1.7112330539232916 -0.9596529289225639 HGGAGGS(ph)PSVTWAR ddPTM_A459_Selumetinib_30min_R2 2 HGGAGGSPSVTWAR 14 0 A0A087WWH3;Q9NZM4-2;Q9NZM4 A0A087WWH3 GLTSCR1 Glioma tumor suppressor candidate region gene 1 protein 1 HGGAGGS(0.999)PS(0.001)VTWAR;HGGAGGS(0.996)PS(0.004)VTWAR 104.26 0.0041756 6585800.0 30504.0 25948.0 34753.0 38690.0 37538.0 25421.0 28907.0 39753.0 26368.0 28335.0 True False 28808.70979718706 27938.128164029702 32517.029816205424 33420.355256027266 32822.14084602213 28922.512001137966 30251.232778133817 39868.67464853657 31642.336783476905 27516.89492682864 1.0469462442544313 1.015308167521124 1.181711450462447 1.2145394800138885 1.1927995848841555 1.0510819653906105 1.099369418627217 1.448879851980141 1.1499239600841011 1.0 14.748030061566022 -5.2647856312128765 23.617016088691635 1.1793424169225535 1.0311271891622817 0.17930597955831273 0.1142155983045378 194.33296940748556 1371582.9014821385 0.0301839262795227 0.06738951311535708 5.43518547336078e-06 5.2647856312128765 -0.14821522776027174 HGGICDCQTSR ddPTM_A459_Selumetinib_30min_R2 1 HGGICDCQTSR 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 93.345 0.033341 215630.0 1159.2 741.22 1103.3 1255.5 839.65 695.49 548.49 1146.0 1250.4 1012.2 False True 1094.7763046452671 798.0691906020534 1032.3148791822132 1084.4987341416963 734.1656604337605 791.2874344703764 573.9958718123164 1149.3346702694876 1500.514939095097 982.975155988563 1.1137375120577362 0.8118915170337622 1.050194272859348 1.1032819370200997 0.7468811962957715 0.804992302856923 0.5839373134868883 1.1692408127178142 1.5265034217330267 1.0 9.941011143690492 -7.9852555017561135 24.355499526313903 1.2914585593630608 0.8898273176549238 0.39403861631670734 0.19720133016222122 149.86170567949733 247546.8107656637 0.10769965640430558 0.05170180972838481 1.034533356600508e-08 7.9852555017561135 -0.4016312417081369 HGGPGPGGPEPELS(ph)PITEGSEAR ddPTM_A459_Selumetinib_30min_R1 2 HGGPGPGGPEPELSPITEGSEAR 23 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 HGGPGPGGPEPELS(0.992)PIT(0.008)EGS(0.001)EAR;HGGPGPGGPEPELS(0.994)PIT(0.006)EGSEAR 212.18 2.3476e-24 8791900.0 1685.15 2166.06 2493.0 2581.4 1960.6399999999999 1941.87 2075.21 1700.15 1030.23 1181.21 True False 1724.4107162688974 1912.4566882260256 2154.4642930687764 2130.606948879369 1783.300458179107 1922.3365508768889 1918.6752389388446 1655.0564991344947 1748.225064977897 1332.8298094597405 1.293796630319878 1.434884390079207 1.6164586639475624 1.598558896085169 1.337980622523714 1.442297086419536 1.4395500650728805 1.2417613167020687 1.3116641393896615 1.0 10.3802768574941 -8.569716345327624 0.616386065075193 0.9985751540177313 1.4778139332958418 0.6508013878289649 0.10077168734681323 0.5797241538659549 0.5074604613838006 0.11119156134354158 0.04662115961979988 2.693293324548213e-09 8.569716345327624 0.4792387792781104 HGGPGPGGPEPELS(ph)PITEGSEAR ddPTM_A459_Selumetinib_30min_R2 1 HGGPGPGGPEPELSPITEGSEAR 23 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 HGGPGPGGPEPELS(0.996)PIT(0.003)EGSEAR 234.18 1.1642e-31 5883200.0 11220.0 9374.8 10414.0 9625.0 12448.0 7830.9 8973.9 10190.0 6792.7 7572.9 True False 10596.437317218688 10093.817015266904 9743.974577905883 8314.058395948894 10884.170953468058 8909.535393167507 9391.20413144551 10219.651212954685 8151.429803895768 7354.2507002428265 1.4408588650464158 1.372514675755291 1.3249445762821428 1.1305106032997183 1.4799836716347838 1.2114810544700805 1.2769763384780213 1.389625079359512 1.1083970530983693 1.0 12.844362642306404 -14.335942798891699 0.12735469172951025 1.1276723995612006e-10 1.4440160480373523 0.4926306462689085 0.10635589722922885 123.12150787180566 1.039062460386472 31.466498054002134 0.8539744637442467 4.613783388931047e-15 14.335942798891699 1.4440160479245852 HGGS(ph)PQPLAT(ph)TPLSQEPVNPPS(ph)EASPTR ddPTM_A459_Selumetinib_30min_R1 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 3 HGGS(0.965)PQPLAT(0.515)T(0.515)PLS(0.007)QEPVNPPS(0.834)EAS(0.15)PT(0.015)R 58.44600000000001 0.013745 7386600.0 517.96 868.49 562.88 593.27 535.63 495.26 781.74 589.42 516.82 428.79 True False 530.0274602252848 766.8067870499526 486.44398767852067 489.66653155716375 487.1823610731575 490.2781340601008 722.7727224175152 573.7866668940114 877.0057929606749 483.82937326829415 1.0954842543868721 1.584870265048462 1.0054040009860596 1.012064497550943 1.00693010385503 1.013328584720363 1.493858707947278 1.1859277228624026 1.8126344563093644 1.0 8.918354547728638 -7.26236804223247 24.990934282775115 1.3885991986435469 1.125614272241286 0.19077912436226152 0.2547219100908108 142.85636812511166 3844286.2868379857 0.10128538205828189 0.07275076654731132 5.465525913744658e-08 7.26236804223247 -0.2629849264022608 HGGS(ph)PQPLAT(ph)TPLSQEPVNPPS(ph)EASPTR ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 3 HGGS(0.999)PQPLAT(0.735)T(0.251)PLS(0.016)QEPVNPPS(0.818)EAS(0.149)PT(0.033)R 83.693 9.8038e-05 7087700.0 7390.7 6394.6 6690.7 6931.5 9160.6 7891.4 7726.0 8809.1 7170.0 7158.8 True False 6979.9544813162365 6885.045258120253 6260.227646283362 5987.417742495559 8009.763531196938 8978.368719003192 8085.274308778565 8834.733022574985 8604.200346538586 6952.106843203837 1.0040056401232702 0.9903537752517221 0.9004792054372935 0.861237877600899 1.152134699861098 1.291460117270805 1.1629962673376455 1.2707993737483398 1.237639256788722 1.0 12.763234538991595 -6.386184830127119 5.044676867897971 1.2087657822079605 0.9410847351357207 0.6683249133399177 0.08500363032523961 0.12623147686858865 4.666244302380972 0.02597057766767527 0.02948126246256964 4.109747783182628e-07 6.386184830127119 -0.26768104707223983 HGGS(ph)PQPLAT(ph)TPLSQEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 3 HGGS(1)PQPLAT(0.712)T(0.285)PLS(0.003)QEPVNPPS(0.072)EAS(0.632)PT(0.296)R 118.01 9.8897e-12 5501900.0 1466.6 1477.0 1207.9 1345.7 1450.1 1231.7 1511.2 1309.7 758.32 1247.6 True False 1500.7689264931707 1304.0721533613287 1043.8738145197651 1110.6987569175508 1318.938711035948 1219.3102162941207 1397.2089673259 1274.962501494837 1286.8136544985464 1407.7416126531027 1.0660826624743613 0.9263576082713125 0.7415237321516883 0.7889933400663425 0.9369181809936042 0.8661463192781135 0.9925180549949416 0.905679344870666 0.9140979018680501 1.0 10.459166839977659 -7.24134281833072 24.254987943559165 0.9452137772370588 0.8805390140515704 0.1141459666435205 0.086826151393191 1380.4039299985627 1666041.6341002334 0.03559932293201321 0.027535449964372863 5.736634516464457e-08 7.24134281833072 -0.06467476318548837 HGGS(ph)PQPLAT(ph)TPLSQEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 3 HGGS(1)PQPLAT(0.968)T(0.032)PLSQEPVNPPS(0.203)EAS(0.746)PT(0.051)R 114.12 1.7817e-10 17442000.0 20179.0 16528.0 23561.0 21258.0 24321.0 17301.0 21331.0 23792.0 18116.0 19168.0 True False 19057.531962937257 17795.64445410371 22045.11091127718 18362.623727904567 21265.578547501318 19684.055707158957 22322.933766574624 23861.230781022376 21739.706203332353 18614.57003555501 1.0237965167358773 0.9560062048230444 1.184293318039021 0.9864651019513634 1.1424157800520083 1.0574542237377045 1.199218339394163 1.2818577455963747 1.1678865620751988 1.0 14.184144672357919 HGGS(ph)PQPLATT(ph)PLSQEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 3 HGGS(0.995)PQPLAT(0.091)T(0.904)PLS(0.01)QEPVNPPS(0.206)EAS(0.702)PT(0.092)R;HGGS(1)PQPLAT(0.283)T(0.717)PLS(0.002)QEPVNPPS(0.367)EAS(0.581)PT(0.05)R 97.826 2.4499e-06 23864600.0 22532.6 20463.1 26271.6 25417.1 31849.7 20442.3 23519.4 26062.0 22366.2 21324.7 True False 21280.328297144537 22032.553970762907 24581.31385835532 21955.24713305689 27848.455946069353 23258.041268276735 24613.098702806965 26137.836105203634 26840.06496384257 20709.000502775463 1.0275883809212571 1.0639119916873854 1.1869869748209665 1.0601789849835777 1.3447513288889554 1.123088546217363 1.1885218071972266 1.2621486054674917 1.296057960897022 1.0 14.337970304692316 -5.1247908269697025 0.9180805930795659 1.2057665724753743 0.9763099129630918 0.2307875201484798 0.09926330049909701 1.834681104032202 1.7392648167819031 0.03470812433691649 0.37799063828320895 7.502554743982756e-06 5.1247908269697025 -0.22945665951228256 HGGS(ph)PQPLATTPLSQEPVNPPS(ph)EASPTR ddPTM_A459_Selumetinib_30min_R1 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(1)PQPLATTPLSQEPVNPPS(0.362)EAS(0.319)PT(0.319)R 153.75 3.584700000000001e-14 55887000.0 2431.6 3129.7 1961.4 1859.2 2520.4 2220.9 3034.2 2832.5 1798.5 2169.4 True False 2488.2515489300367 2763.273269041943 1695.0526531989956 1534.5256215063623 2292.4302650127615 2198.5597624158577 2805.3278511515655 2757.37289874332 3051.9231427571954 2447.8636217454628 1.0164992554429053 1.1288509884678852 0.6924620465540188 0.6268836253271987 0.936502444273481 0.8981545143630847 1.1460311049319043 1.1264405721986914 1.2467700878617596 1.0 11.257307467810197 -7.232330173082335 4.302975586634342 1.1424024228996634 0.8738579931737406 0.4030224770574866 0.1465970416756216 0.23084543153896347 10.23266234910501 0.0657282868405005 0.04795380296242568 5.8569272137227186e-08 7.232330173082335 -0.26854442972592285 HGGS(ph)PQPLATTPLSQEPVNPPS(ph)EASPTR ddPTM_A459_Selumetinib_30min_R2 2 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(0.999)PQPLAT(0.001)T(0.001)PLSQEPVNPPS(0.517)EAS(0.363)PT(0.12)R;HGGS(0.989)PQPLAT(0.005)T(0.006)PLSQEPVNPPS(0.692)EAS(0.24)PT(0.068)R 87.016 0.00010829 335202000.0 14923.5 15090.6 18580.5 18965.4 19859.1 14083.8 16805.7 16772.4 15903.5 15015.0 True False 14094.111613503837 16248.000496073177 17385.050858918785 16382.27980286017 17364.22231539343 16023.715609992789 17587.198349862785 16821.204907179712 19084.6443809172 14581.477936344874 0.9665763426061046 1.1142903735138145 1.1922694623146466 1.1234992690299748 1.1908410375955416 1.0989088815238053 1.2061327683407208 1.153600820205765 1.3088278475083803 1.0 13.831849334013645 -4.788982127189202 2.8710334086757263 1.1640300763222664 0.9333805191616849 0.36701970714465504 0.07567529286894503 0.4000071276058498 4.678163098882738 0.01801526024102434 0.2170815106083011 1.625615654420383e-05 4.788982127189202 -0.23064955716058155 HGGS(ph)PQPLATTPLSQEPVNPPS(ph)EASPTRDR ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTRDR 30 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(0.952)PQPLAT(0.021)T(0.023)PLS(0.004)QEPVNPPS(0.806)EAS(0.151)PT(0.043)RDR 81.426 3.2217e-05 5619400.0 8005.1 5096.7 5909.8 7838.2 8885.3 6010.9 5009.5 7972.0 4408.3 6279.4 True False 7560.208588954308 5487.600501526521 5529.569902103726 6770.623638350817 7769.049178410155 6838.846913482565 5242.451676135932 7995.197200164351 5290.083178193312 6098.097406159441 1.239765140733575 0.8998873150146337 0.9067696912349305 1.11028459983471 1.2740119845516003 1.1214722327286741 0.8596864443065052 1.3110969975797249 0.867497323484865 1.0 12.57414347965731 -4.720817094929634 23.58224475590108 1.0511075814886548 1.2397691690732497 0.12604883908548958 0.15569256467560003 9867.561349474181 5727577.6938753575 0.03865261513052481 12.751807464619278 1.9018790961956454e-05 4.720817094929634 0.18866158758459495 HGGS(ph)PQPLATTPLSQEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 3 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(1)PQPLATTPLSQEPVNPPS(0.043)EAS(0.599)PT(0.358)R;HGGS(0.998)PQPLAT(0.002)TPLSQEPVNPPS(0.13)EAS(0.435)PT(0.435)R;HGGS(1)PQPLATTPLSQEPVNPPS(0.043)EAS(0.573)PT(0.384)R 198.18 1.4532999999999997e-39 215968000.0 7066.0 8382.6 6486.9 6421.7 7534.200000000001 6820.700000000001 8449.3 7800.5 4006.0 7440.0 True False 7230.624051957411 7401.161295034983 5606.014609991111 5300.270645238489 6852.73294027105 6752.089950700098 7811.962498429539 7593.605400405036 6797.889413336294 8394.996471737006 0.8613016189226969 0.8816157719603676 0.6677804605236686 0.6313606757409169 0.8162877689516352 0.8042993196521291 0.9305498250927994 0.904539439173087 0.8097548862852285 1.0 13.035314003486263 -7.031262928588202 2.4345683011339423 0.9031603126919319 0.7636307263493709 0.37350410752769125 0.08496754850791946 0.366135760374187 4.32619216452095 0.038934498252845826 0.030288799029077437 9.305443389805926e-08 7.031262928588202 -0.13952958634256096 HGGS(ph)PQPLATTPLSQEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(1)PQPLATTPLSQEPVNPPS(0.32)EAS(0.559)PT(0.121)R;HGGS(0.997)PQPLAT(0.003)T(0.001)PLS(0.001)QEPVNPPS(0.335)EAS(0.484)PT(0.18)R 152.15 7.6727e-14 32438700.0 33307.0 22668.7 28497.0 33325.0 35954.0 27457.0 27612.7 32607.0 24969.6 29583.0 True False 31455.93027848511 24407.316398641145 26663.534045187633 28786.077511168503 31437.13708716183 31238.952520170125 28896.74526352705 32701.880971620565 29964.217708916287 28728.861924135224 1.0949243433851052 0.8495747747715849 0.9281096520843207 1.0019915716530772 1.0942701862043263 1.0873717379638406 1.0058437170200183 1.1382936455323902 1.0430005124478403 1.0 14.810213222091756 -6.018755168343313 4.0585655137421925 1.0663757482642833 0.9478301588965296 0.3160149483739597 0.06840734829788586 0.22032994682021442 8.292359917906229 0.019556270668395905 0.02762799365930393 9.577338374897455e-07 6.018755168343313 -0.11854558936775372 HGGS(ph)PQPLATTPLSQEPVNPPSEAS(ph)PTRDR ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTRDR 30 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(0.955)PQPLAT(0.019)T(0.022)PLS(0.004)QEPVNPPS(0.054)EAS(0.536)PT(0.411)RDR 70.472 0.00048352 4542800.0 7982.5 5992.9 6741.4 7112.7 5986.1 3488.9 7242.0 7381.3 5575.3 5713.0 True False 7538.864606479335 6452.536159789335 6307.665663481348 6143.937989908123 5234.072601587012 3969.4643059191317 7578.767349750764 7402.778360960006 6690.515786897709 5548.050845843372 1.3588312032373477 1.1630275819522469 1.1369156193309011 1.1074047734279855 0.9434074681396271 0.7154700661932604 1.3660234126060353 1.3343025445605288 1.2059218584685967 1.0 12.437765294153081 -10.495821346685231 15.191753144329715 1.0000005420280769 1.1400136779400052 0.05025262598615743 0.19014400329754777 0.0 0.0 0.19948503055593841 0.04838222657127651 3.192851010419379e-11 10.495821346685231 0.14001313591192832 HGGS(ph)PQPLATTPLSQEPVNPPSEASPT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGS(1)PQPLATTPLSQEPVNPPS(0.167)EAS(0.229)PT(0.604)R 152.79 4.9125e-14 261310000.0 15329.0 12838.0 21447.0 19837.0 21689.0 14417.0 13525.0 17310.0 18763.0 16625.0 True False 14477.07554684896 13822.633319323766 20067.123369728004 17135.1663792663 18964.233917879872 16402.81088550435 14153.939299279064 17360.369234175243 22516.12428202281 16144.993053062493 0.8966913456864479 0.8561560400734761 1.2429316819013145 1.061330055884786 1.1746201348957908 1.0159689032751211 0.8766767042116657 1.0752788296110296 1.3946196327258127 1.0 13.978799199732409 -5.2388274718784364 24.6808774341369 1.097434018827179 0.8764236191843587 0.312752469257644 0.13525022083664404 867.9426653187388 947354.3456523799 0.03521085073582483 0.09299500489113424 5.769956355477098e-06 5.2388274718784364 -0.2210103996428202 HGGS(ph)PQPLATTPLSQEPVNPPSEASPTR ddPTM_A459_Selumetinib_30min_R2 2 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HGGS(0.99)PQPLAT(0.005)T(0.005)PLS(0.001)QEPVNPPSEASPTR;HGGS(0.966)PQPLAT(0.017)T(0.017)PLSQEPVNPPSEASPTR 95.323 9.2711e-07 20071800.0 22826.8 20469.7 23043.9 25431.9 26850.0 15437.3 18523.9 16151.1 15661.2 24478.0 True False 21558.17783892045 22039.66016954057 21561.280562301272 21968.031347525462 23476.862957954472 17563.647949143113 19385.298054411494 16198.097027041456 18793.87761048954 23771.256538518133 0.9069010636433253 0.9271558755772231 0.9070315878070689 0.9241426220750768 0.9876155650381108 0.738860729582535 0.8154931996548108 0.6814152630423475 0.7906135538117887 1.0 14.536930545092144 -6.7643084598840515 24.998758980595227 0.7860035369886522 0.9287150157346318 0.3676229648785492 0.0801780485477369 69.5852672681571 606302.6945357402 0.026040091119894353 0.02398002704657471 1.720646043202183e-07 6.7643084598840515 0.14271147874597956 HGGSPQPLATTPLS(ph)QEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 HGGSPQPLATT(0.001)PLS(0.999)QEPVNPPS(0.412)EAS(0.461)PT(0.127)R 96.867 4.6562e-06 3827900.0 3890.0 4097.5 3934.5 5307.6 5836.9 3879.4 4471.3 5392.0 4482.2 5037.1 True False 3673.809372903806 4411.765074460913 3681.3585535597 4584.695723879306 5103.616439451932 4413.752136313072 4679.224309712867 5407.689827306348 5378.765243131834 4891.665835042474 0.7510344117510445 0.9018942060302461 0.7525776857420463 0.9372463039146861 1.0433289213852477 0.902300419765846 0.9565707199768761 1.1054904422471437 1.0995774087019439 1.0 12.256110136893392 -6.03174440406226 0.543779169878846 1.0610604808876891 0.7506461410204007 0.6302588107705127 0.07217006358956228 0.918734384426098 0.4954542817938562 0.05540159745669374 0.1558130291708959 9.295132735786905e-07 6.03174440406226 -0.3104143398672884 HGGSPQPLATTPLSQEPVNPPS(ph)EASPTR ddPTM_A459_Selumetinib_30min_R1 4 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HGGSPQPLATTPLSQEPVNPPS(0.525)EAS(0.343)PT(0.132)R;HGGSPQPLATTPLSQEPVNPPS(0.916)EAS(0.042)PT(0.042)R;HGGSPQPLATTPLSQEPVNPPS(0.541)EAS(0.336)PT(0.123)R;HGGSPQPLATTPLSQEPVNPPS(0.553)EAS(0.346)PT(0.101)R 175.28 9.217599999999999e-24 145178000.0 5752.860000000001 6790.16 4991.49 5038.32 5775.3 5366.469999999999 6368.53 5086.360000000001 2447.52 4851.35 True False 5886.890444883062 5995.164910540259 4313.673074291963 4158.471992979741 5252.9251347120335 5312.488184164905 5888.146654767078 4951.453209974253 4153.262680211897 5474.068028650715 1.0754141917988005 1.0951937168413284 0.7880196321482738 0.7596675765106904 0.9596017271284825 0.9704826751074124 1.075643675589912 0.9045289872283009 0.7587159418688519 1.0 12.418397648482088 -5.237041541374426 23.99574281899755 0.9042823312189227 1.0853040628467046 0.34525898974351155 0.10088855661260027 577.7080635982113 568182.9578128083 0.027784825641560994 0.07341297974971212 5.79373275245448e-06 5.237041541374426 0.1810217316277819 HGGSPQPLATTPLSQEPVNPPS(ph)EASPTR ddPTM_A459_Selumetinib_30min_R2 3 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HGGSPQPLATTPLSQEPVNPPS(0.475)EAS(0.475)PT(0.049)R;HGGSPQPLATTPLSQEPVNPPS(0.578)EAS(0.382)PT(0.039)R;HGGSPQPLATTPLSQEPVNPPS(0.714)EAS(0.264)PT(0.022)R 157.67 2.0257999999999998e-17 176822000.0 70267.0 48809.0 79458.0 86826.0 99371.0 80147.0 83886.0 78329.0 83352.0 80916.0 True False 66361.84144108785 52552.49335432886 74345.75878732903 75000.1490167955 86887.12659198868 91186.52174797234 87786.86521695562 78556.92442193591 100024.72904946783 78579.74483498382 0.8445158683124593 0.6687791295923425 0.9461186078353131 0.9544463293218194 1.1057191236043107 1.1604329072264428 1.1171691305603828 0.9997095891174521 1.2729072773081425 1.0 16.26186986261837 -5.7457943577389745 1.447907927404321 1.1126970972321595 0.7553006170169081 0.6868239800051295 0.09084087729818993 0.22406794668500596 0.9419833264097152 0.02845483142138824 0.06791388397093263 1.7955836502378725e-06 5.7457943577389745 -0.3573964802152514 HGGSPQPLATTPLSQEPVNPPSEAS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 HGGSPQPLATTPLSQEPVNPPSEASPTR 28 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HGGSPQPLATTPLSQEPVNPPS(0.063)EAS(0.878)PT(0.06)R 192.06 6.2038e-33 71033000.0 22820.0 20066.0 29566.0 30502.0 35319.0 26436.0 27121.0 25428.0 25994.0 25402.0 True False 21551.755755697908 21604.997677640677 27663.755749026823 26347.574981115133 30881.91146413384 30077.319037885336 28382.18023924198 25501.991270167986 31193.526333043796 24668.57825767781 0.8736521225737918 0.8758104116079883 1.1214167050919035 1.0680621601252902 1.2518723674122645 1.2192562831838156 1.150539765314945 1.0337843958328157 1.264504423692726 1.0 14.59038694967861 -5.287084422148271 3.183960965349088 1.1485082411463492 0.8640056115265726 0.6088779994357981 0.08443325228845804 0.15495560153952073 3.195839654990958 0.022337543126175818 0.061244715408412316 5.163159932737638e-06 5.287084422148271 -0.28450262961977657 HGGVCAPAAVAT(ph)SPPGAIPK ddPTM_A459_Selumetinib_30min_R1 1 HGGVCAPAAVATSPPGAIPK 20 0 A0A494BZT8;Q9Y6A5;E7EMT0 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 HGGVCAPAAVAT(0.5)S(0.5)PPGAIPK 88.133 0.002745 34445000.0 4097.2 5147.2 6462.8 5870.6 4602.8 4756.7 5251.7 4610.6 3238.8 4290.7 True False 4192.656788236614 4544.563431131638 5585.187257619287 4845.409914810266 4186.477552690344 4708.85191673804 4855.560040832072 4488.31191066053 5496.007047407288 4841.453139957251 0.8659914011423511 0.9386775622435882 1.153617952330032 1.000817270091981 0.8647150827793223 0.9726112761218667 1.0029137741225658 0.9270588356247441 1.1351978194414203 1.0 12.241224415459573 -8.2525726559591 24.959994955359686 1.0675989140899236 0.9704187461193741 0.19067726877692115 0.08345771659370563 1009.5835723179315 2842018.3319472144 0.06055722801740784 0.022062048608082613 5.590199976422844e-09 8.2525726559591 -0.09718016797054951 HGGVCAPAAVAT(ph)SPPGAIPK ddPTM_A459_Selumetinib_30min_R2 2 HGGVCAPAAVATSPPGAIPK 20 0 A0A494BZT8;Q9Y6A5;E7EMT0 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 HGGVCAPAAVAT(0.557)S(0.443)PPGAIPK;HGGVCAPAAVAT(0.581)S(0.419)PPGAIPK 114.01 0.00067642 44232400.0 266068.0 404310.0 346478.0 434694.0 357202.0 330334.0 301757.0 264396.0 256769.0 383906.0 True False 251281.00571459407 435319.2769384473 324185.98269672366 375487.9273110238 312327.09133360354 375834.51002651 315789.2984201521 265165.348586886 308129.974725295 372821.63627242215 0.6739979155366994 1.167634156887713 0.8695471269801514 1.007151653174585 0.837738642146254 1.0080812738879947 0.847025139360216 0.7112391631507371 0.8264809355113265 1.0 18.508126061996492 -7.502338682915723 22.72514166560665 0.8171424990208885 0.9345679683916892 0.06374622553963516 0.1382868088055968 454.7341813598188 503113.6307216566 0.054448217283072774 0.03612427559984356 3.145294511354918e-08 7.502338682915723 0.11742546937080067 HGGVCAPAAVATS(ph)PPGAIPK ddPTM_A459_Selumetinib_30min_R1 1 HGGVCAPAAVATSPPGAIPK 20 0 A0A494BZT8;Q9Y6A5;E7EMT0 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 HGGVCAPAAVAT(0.185)S(0.815)PPGAIPK 79.635 0.0029213 33838000.0 5346.0 6063.4 6719.4 7186.5 5704.6 5565.1 5351.2 5205.3 3488.1 5494.0 True False 5470.551398494811 5353.494309201815 5806.9423870221935 5931.512682312535 5188.619937228934 5509.120146706514 4947.554675724164 5067.238534802686 5919.050939255702 6199.208416091812 0.8824596676398935 0.8635770811165656 0.9367232067805011 0.9568177554598105 0.8369810448315291 0.8886812278170907 0.7980945862186817 0.8174008993872871 0.9548075402483838 1.0 12.597868292566725 -6.276508012736522 24.652840186820676 0.8696036345741859 0.9085023934572777 0.018682671805042683 0.06273521628512799 1851.8906034722816 3029752.859406671 0.019283394188060205 0.021945399831183092 5.290442362493211e-07 6.276508012736522 0.0388987588830918 HGGVCAPAAVATS(ph)PPGAIPK ddPTM_A459_Selumetinib_30min_R2 2 HGGVCAPAAVATSPPGAIPK 20 0 A0A494BZT8;Q9Y6A5;E7EMT0 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 HGGVCAPAAVAT(0.192)S(0.808)PPGAIPK;HGGVCAPAAVAT(0.043)S(0.957)PPGAIPK 144.08 3.5841e-05 11899900.0 55708.0 56459.0 61305.0 64181.0 59207.0 48225.0 49941.0 57687.0 49742.0 64164.0 True False 52611.972376793135 60789.223755701874 57360.703043837144 55439.43708159957 51768.887342704256 54867.556007036656 52263.35545621411 57854.85961940302 59691.789907604216 62311.41860190689 0.8443391846511913 0.9755711733040462 0.920548822845798 0.8897155340947892 0.8308089994458896 0.8805377447362043 0.8387444328641029 0.928479256571323 0.9579590907560801 1.0 15.927208941688907 -8.265929911356945 2.1878184800351033 0.9938355019150413 0.8863106345145318 0.46435448210156505 0.04138895086266094 0.29632715233166096 2.59974493430193 0.04084248425997405 0.011830383419859869 5.420883683090051e-09 8.265929911356945 -0.10752486740050948 HGHFGWPGWEMGPPGNWS(ph)PRPPR ddPTM_A459_Selumetinib_30min_R1 2 HGHFGWPGWEMGPPGNWSPRPPR 23 1 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8 Q13501 SQSTM1 Sequestosome-1 1 HGHFGWPGWEMGPPGNWS(1)PRPPR;HGHFGWPGWEMGPPGNWS(1)PRPPR 62.028 0.0035195 53792000.0 3961.3999999999996 3891.0 5033.9 4221.9 3923.3 3498.5 2713.9 2569.6000000000004 2132.34 2745.6 True False 4053.6929124574167 3435.439911123175 4350.3240292334185 3484.6244198782856 3568.4382077148716 3463.3082663838436 2509.1883380265763 2501.4458607628717 3618.425240048308 3098.024504408752 1.3084767104613497 1.1089130851722613 1.4042251838365185 1.1247891728807726 1.1518431189413385 1.1179086096495563 0.8099317272848514 0.8074325613638955 1.1679782503007905 1.0 11.597132840103052 -6.951371279721759 2.5318531656329837 0.9319621879707761 1.2230624693129553 0.49963687571488125 0.12733997013898438 0.2312225709191115 3.0024067299618844 0.05109689049441393 0.04208850045483587 1.1184812814506786e-07 6.951371279721759 0.29110028134217913 HGIVEDWDLMER ddPTM_A459_Selumetinib_30min_R1 1 HGIVEDWDLMER 12 0 F8WDR7;B4DXW1;P61158 F8WDR7 ACTR3 Actin-related protein 3 0 199.8 0.00014747 5770500.0 2599.6 3423.1 3373.1 3264.3 2931.1 3060.9 3073.0 2697.6 1746.8 2437.4 False True 2660.1656220589416 3022.321860643984 2915.0515471120298 2694.251283500009 2665.9825225277364 3030.110125074836 2841.2011359135054 2626.0508849602734 2964.192018775795 2750.2640322865277 0.967240087071684 1.0989206218616296 1.059916979930287 0.9796336831195256 0.9693551205377468 1.1017524461299262 1.033064863067483 0.9548359190724734 1.0777845268591943 1.0 11.425354412312211 -7.25137008705525 0.0030230159867252367 2.0966322006732018e-05 2.048083022682153 0.0037202066860865246 0.054174800595647006 119219.84390684936 212.61899210818243 71672.52063713233 72365.64622149174 5.6057007875862735e-08 7.25137008705525 2.0480620563601466 HGIVEDWDLMER ddPTM_A459_Selumetinib_30min_R2 1 HGIVEDWDLMER 12 0 F8WDR7;B4DXW1;P61158 F8WDR7 ACTR3 Actin-related protein 3 0 161.99 7.005399999999999e-05 0.0 10725.0 10401.0 12600.0 12285.0 16782.0 10529.0 10511.0 10395.0 10108.0 10341.0 False True 10128.947435576689 11198.72325551383 11789.329717842726 10611.761807192941 14673.695127016457 11979.2741772543 10999.782327151372 10425.247729015107 12129.882441117443 10042.428460855295 1.008615343894023 1.115140954119384 1.1739520738232523 1.0566927958269126 1.4611699933152151 1.1928662697422936 1.0953309122417727 1.0381201887224805 1.2078634653359894 1.0 13.293820563657558 -9.57371536700863 0.6549515861182468 0.9927364511752024 1.1579607979700126 0.11311163341341768 0.12215359237844937 12.12351336198894 5.595376313798018 0.38515467760294814 0.049024540077723534 2.668607074393747e-10 9.57371536700863 0.16522434679481024 HGLAT(ph)PPLSSTLR ddPTM_A459_Selumetinib_30min_R2 1 HGLATPPLSSTLR 13 0 Q66GS9 Q66GS9 CEP135 Centrosomal protein of 135 kDa 1 HGLAT(1)PPLSSTLR 99.069 0.016326 3497100.0 14237.0 13396.0 15476.0 16650.0 19935.0 14306.0 16163.0 14735.0 16715.0 14370.0 True False 13445.764535226604 14423.43012507099 14480.291008994764 14382.24127714795 17430.587078838824 16276.521643062026 16914.611526376906 14777.876410489433 20058.467056121688 13955.100762256137 0.9635017879335478 1.033559726353358 1.0376342855337233 1.0306081999814065 1.2490477407359688 1.1663492740292176 1.212073765323519 1.0589587751640337 1.437357379057635 1.0 13.768504920913832 -6.215378691394759 8.590427044116835 1.1903828155382377 1.018680541380628 0.3634023945809626 0.11079996559281939 0.41000728394122626 72.45039299596765 0.030609985049035265 0.03943173750025621 6.090056315209629e-07 6.215378691394759 -0.17170227415760975 HGLLLPAS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 HGLLLPASPVR 11 0 Q96E09 Q96E09 FAM122A Protein FAM122A 1 HGLLLPAS(1)PVR 77.42 0.032752 30490000.0 8248.3 10410.0 10936.0 10769.0 10195.0 8520.8 8548.0 7662.0 4717.4 7217.3 True False 8440.469341602084 9191.192360522302 9450.951267148075 8888.396309166315 9272.864050073447 8435.08848826739 7903.217477965718 7458.778870316436 8005.083254736059 8143.710757455301 1.0364402166266906 1.128624607904703 1.1605214807630586 1.091443025653788 1.138653413197963 1.0357794793418151 0.970468833354694 0.9158943745009813 0.9829773543231096 1.0 12.991470606366063 -7.037831026114083 2.764409898070546 0.9600248565315336 1.1136711368486942 0.7643276286401502 0.037449087286837233 0.1244077480982657 1.8965280711376016 0.015352599103643994 0.012038349196160555 9.165770395713817e-08 7.037831026114083 0.15364628031716066 HGLLLPAS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 3 HGLLLPASPVR 11 0 Q96E09 Q96E09 FAM122A Protein FAM122A 1 HGLLLPAS(1)PVR;HGLLLPAS(1)PVR;HGLLLPAS(1)PVR 163.71 0.00064187 45847600.0 244399.0 260111.0 296689.0 310726.0 313068.0 218407.0 228689.0 241074.0 194692.0 260803.0 True False 230816.28198671382 280060.6773113119 277600.3527505582 268404.58276775276 273737.5989765696 248490.58174865454 239323.49163865656 241775.4854280509 233635.84014899458 253272.93974242825 0.9113341607731476 1.105766283583734 1.0960521603013345 1.0597444126510829 1.0808008121789614 0.9811177696336717 0.9449232590028848 0.9546044898200733 0.9224666495623098 1.0 17.950333418897905 -6.8999020673850815 4.523856473688944 0.9529869523383667 1.0565263392861766 0.4146516028232996 0.05383457915479794 0.19891245113281006 7.106107425406386 0.01925810292805479 0.01688570855963725 1.2592093291925373e-07 6.8999020673850815 0.10353938694780984 HGLQLGAQS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 HGLQLGAQSPGR 12 0 Q8N1G0;A6PVV7 Q8N1G0 ZNF687 Zinc finger protein 687 1 HGLQLGAQS(1)PGR 93.766 0.019849 34478000.0 912.27 946.67 974.23 1150.3 879.25 778.2 838.17 1004.6 461.41 798.83 True False 933.5241160315861 835.8334363050569 841.9349170623325 949.4216988052754 799.7219927441952 770.3720145490666 774.9461620854615 977.9547445993076 782.979069946955 901.3676117631276 1.0356752382144712 0.9272947301380378 0.9340638670336276 1.0533124181688214 0.8872317823578022 0.8546701750711612 0.8597448499060463 1.0849677000112874 0.8686567608252556 1.0 9.8159718013676 -4.756680587502567 24.645199017267863 0.9401192982064346 1.035675413625188 0.11949600817605321 0.0769715329118633 280.6675147867032 1453333.9649586172 0.019168216394376863 0.15127464845585864 1.7511341295464128e-05 4.756680587502567 0.09555611541875342 HGLQLGAQS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 3 HGLQLGAQSPGR 12 0 Q8N1G0;A6PVV7 Q8N1G0 ZNF687 Zinc finger protein 687 1 HGLQLGAQS(1)PGR;HGLQLGAQS(1)PGR;HGLQLGAQS(1)PGR 134.04 0.0016559 71043000.0 303633.0 262420.0 310771.0 326680.0 335551.0 213864.0 256958.0 260091.0 227236.0 304415.0 True False 286758.2933992035 282546.77018670726 290776.3322018814 282185.6204455665 293396.0835159992 243321.82473590234 268907.0561526176 260847.82174961708 272689.54950433 295625.74798484275 0.9700044578454855 0.9557583265757823 0.983596098052968 0.9545366814937738 0.9924578136916617 0.8230738573839579 0.9096198757572529 0.8823582638782573 0.9224147468992154 1.0 18.17341240316422 -6.72462249678291 24.99998986589584 0.9002734500519898 0.9701639805712864 0.3557418588245489 0.04234729699614966 166.35454581238045 112960.24257424477 0.013083831123750299 0.013083503436902611 1.8852871317839583e-07 6.72462249678291 0.06989053051929661 HGLTSGSAS(ph)PPPPALPLYPDPVR ddPTM_A459_Selumetinib_30min_R1 2 HGLTSGSASPPPPALPLYPDPVR 23 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 HGLTS(0.002)GS(0.041)AS(0.957)PPPPALPLYPDPVR;HGLTSGS(0.011)AS(0.989)PPPPALPLYPDPVR 132.52 4.5941000000000015e-06 74725000.0 2970.0 3395.4 3174.3 3625.6000000000004 3684.9 3364.3 3639.8999999999996 2422.0 1062.97 2341.0 True False 3039.1952213860054 2997.8649895213653 2743.247495181797 2992.4570209409762 3351.6014456219364 3330.458196539994 3365.3394124996967 2357.7606922352415 1803.782453742906 2641.49015327101 1.1505608747481073 1.1349143156218278 1.0385227034765885 1.132866998287068 1.2688298086107122 1.2608255201768672 1.27403064831884 0.892587348590181 0.6828654846618475 1.0 11.367136316602881 -7.861077030293808 5.5916637070332245 0.8266073326056809 1.1769467981761725 0.6840560173759999 0.10017520436773301 0.11855260296044494 5.489754573696076 0.05867354924557504 0.027658080716524328 1.3769652165565308e-08 7.861077030293808 0.35033946557049167 HGLYLPTR ddPTM_A459_Selumetinib_30min_R2 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 95.815 0.036144 0.0 28995.0 25360.0 31934.0 30165.0 34793.0 26052.0 28443.0 26723.0 22907.0 31442.0 False True 27383.573976181462 27305.03045474769 29879.401207110295 26056.474962472537 30421.992286633504 29640.426523490278 29765.655858735263 26800.759505769212 27489.0400750571 30534.187763873157 0.8968168463475759 0.8942445322568535 0.9785556255228908 0.8533541210911635 0.9963255784595522 0.9707291627570215 0.9748304454311639 0.8777295703106539 0.900270879567363 1.0 14.898137848289885 -5.218477120417327 23.746853444328185 0.9402983993579821 0.8955306029932302 0.135006024248836 0.04833747244059809 586.8949104811493 324394.87848975183 0.01236122388450855 0.03270391779695813 6.046762061700227e-06 5.218477120417327 -0.04476779636475192 HGQEEAAQS(ph)PYR ddPTM_A459_Selumetinib_30min_R1 2 HGQEEAAQSPYR 12 0 J3KQ72;Q9NRD1 J3KQ72 FBXO6 F-box only protein 6 1 HGQEEAAQS(1)PYR;HGQEEAAQS(1)PYR 252.2 1.4685e-18 5079670.0 642.04 498.07 536.12 922.94 568.17 643.625 513.18 659.52 481.36 483.02 True False 656.9982828076336 439.75573285353903 463.31784869636294 761.7658547294969 516.7791238185608 637.1507168647431 474.4704194364118 642.0273871771209 816.8327628566045 545.0203220132266 1.2054564871650593 0.8068611666242914 0.8500927946776984 1.3976833963101476 0.9481832198653678 1.1690402928668788 0.8705554642142267 1.1779879781465104 1.4987198272522058 1.0 9.090166214014934 -7.9937787033949075 24.520040545153766 1.2790245890479286 1.0344293532535005 0.15418515010927325 0.20627770063792258 182.81519521553415 720531.1239157148 0.10956177693319892 0.05240279604721602 1.014428160257765e-08 7.9937787033949075 -0.2445952357944281 HGQEEAAQS(ph)PYR ddPTM_A459_Selumetinib_30min_R2 1 HGQEEAAQSPYR 12 0 J3KQ72;Q9NRD1 J3KQ72 FBXO6 F-box only protein 6 1 HGQEEAAQS(1)PYR 151.44 0.00034563 8687800.0 12355.0 14217.0 12282.0 12950.0 15046.0 11610.0 11163.0 11755.0 10395.0 13702.0 True False 11668.358560983675 15307.398185139898 11491.789491630505 11186.18766000396 13155.78696705336 13209.17211491334 11682.101619064868 11789.205103854993 12474.290460567441 13306.387657928564 0.876899039840548 1.1503796957259875 0.8636295429724057 0.8406629919081539 0.988682075500373 0.9926940695315382 0.877931856442205 0.8859808842883392 0.9374663343085965 1.0 13.69983134934744 -5.306228406235485 24.999948748286972 0.919539118294668 1.0136402981287738 0.16258369377328064 0.08156485315952772 638.3495586529145 356307.196806956 0.0206857779604062 0.04306135311448122 4.940507850915324e-06 5.306228406235485 0.09410117983410582 HGRDDSFDSLDS(ph)FGSR ddPTM_A459_Selumetinib_30min_R1 1 HGRDDSFDSLDSFGSR 16 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 HGRDDS(0.325)FDS(0.117)LDS(0.554)FGS(0.004)R 81.788 0.011574 3965500.0 1106.7 1068.6 1385.4 1200.6 1398.1 872.44 1247.6 1023.0 649.53 1175.9 True False 1132.4839567366637 943.4878152213375 1197.2702894574732 990.9377480532153 1271.6421018546027 863.6640457121401 1153.4925275514777 995.8667168276846 1102.204970205772 1326.8382192359604 0.8535207535616417 0.7110797695928828 0.9023483587523602 0.7468414262470007 0.95840026569845 0.6509188785724517 0.8693543122504406 0.7505562489759597 0.8307003478091398 1.0 10.373776758961295 -11.881798546730492 1.104700945728608 1.482950926881997 0.8061795819780972 0.29509774860700866 0.08889018395720094 13527.56421217953 1353.6720958328103 16078.752952393914 0.023943524220355943 1.312808721582764e-12 11.881798546730492 -0.6767713449038997 HGS(ph)GADSDYENTQSGDPLLGLEGK ddPTM_A459_Selumetinib_30min_R1 3 HGSGADSDYENTQSGDPLLGLEGK 24 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QL89 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 HGS(0.964)GADS(0.036)DYENTQSGDPLLGLEGK;HGS(1)GADSDYENTQSGDPLLGLEGK;HGS(0.948)GADS(0.052)DYENTQSGDPLLGLEGK 200.52 5.1553e-31 55373900.0 18035.6 21238.8 18113.2 18770.6 18716.8 17977.5 19489.1 18277.7 9685.7 16167.0 True False 18455.794388831462 18752.151422349747 15653.526928685658 15492.667077800832 17023.868744719424 17796.662672264007 18019.021496235582 17792.916021663117 16435.925484461153 18242.191929915603 1.0117092540050283 1.02795494611576 0.8580946296818224 0.8492766185840973 0.9332139915051417 0.9755769888090604 0.9877662490046473 0.9753716050144329 0.900984133244847 1.0 14.154991469601772 -6.75103383148793 21.90992618358714 0.9676396692536345 0.9320040945272517 0.06768706198585162 0.058211169186245505 146.07499619569228 307571.7553915273 0.021453792330670896 0.021165153042010533 1.7740512771259945e-07 6.75103383148793 -0.03563557472638279 HGS(ph)GADSDYENTQSGDPLLGLEGK ddPTM_A459_Selumetinib_30min_R2 5 HGSGADSDYENTQSGDPLLGLEGK 24 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QL89 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 HGS(0.995)GADS(0.005)DYENTQSGDPLLGLEGK;HGS(0.845)GADS(0.078)DY(0.067)ENT(0.01)QSGDPLLGLEGK;HGS(0.781)GADS(0.219)DYENTQSGDPLLGLEGK;HGS(0.545)GADS(0.455)DYENTQSGDPLLGLEGK;HGS(0.858)GADS(0.127)DY(0.013)ENT(0.002)QSGDPLLGLEGK 152.26 4.2366e-10 71638000.0 184206.0 167333.0 194263.0 197770.0 207498.0 153882.0 167094.0 186758.0 131282.0 186113.0 True False 173968.56795504314 180166.90303960125 181764.33007756187 170833.38482772035 181430.24618434394 175077.84869828547 174864.20209047946 187301.4348605488 157542.06832556223 180739.4341103532 0.9625379697096096 0.9968322846999599 1.0056705719604218 0.9451915442172705 1.0038221436145969 0.9686754280274499 0.9674933583321582 1.0363064141618872 0.871652990953665 1.0 17.46355178522513 -8.25218249981053 24.99937438210494 0.9358264897106662 0.9849091467326314 0.21640732615900338 0.038018232878073294 849.9589247210813 2295435.772944367 0.02428379099455548 0.008879491662826968 5.595224288196924e-09 8.25218249981053 0.04908265702196524 HGS(ph)GPPSSGGGLYR ddPTM_A459_Selumetinib_30min_R1 1 HGSGPPSSGGGLYR 14 0 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 1 HGS(1)GPPSSGGGLYR 152.0 0.00039092 10325000.0 744.41 943.67 1059.0 923.21 880.17 799.01 857.84 864.13 363.73 601.73 True False 761.7533046302881 833.1846776997188 915.1936166706114 761.9887042980245 800.5587789066352 790.9726848430342 793.1324381490538 841.210465310173 617.2232442118852 678.9679068465462 1.1219282928529526 1.2271341094300459 1.347918815369656 1.1222749950539883 1.1790819136427457 1.164963287464782 1.168144223241335 1.238954679341413 0.9090609997732693 1.0 9.407199573187919 -8.26088527576338 24.998487005463343 0.9545304787617052 1.1973572796277576 0.6850947976625156 0.06556247889348757 27.546573434001647 1242934.945680952 0.05187550248579611 0.016848064180190525 5.484218181658322e-09 8.26088527576338 0.24282680086605246 HGS(ph)GPPSSGGGLYR ddPTM_A459_Selumetinib_30min_R2 2 HGSGPPSSGGGLYR 14 0 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 1 HGS(0.956)GPPS(0.018)S(0.026)GGGLYR;HGS(0.997)GPPS(0.001)S(0.001)GGGLYR 115.83 0.0027403 30833000.0 11293.1 6798.5 11580.4 10427.7 14911.3 10642.099999999999 13079.2 14224.7 7999.0 8169.8 True False 10665.47471186118 7319.9230893770555 10835.329671786189 9007.429271214161 13038.009185286637 12107.95267563473 13687.408715943124 14266.091521974155 9599.023510733914 7933.91664631038 1.3442887274119641 0.9226115442971211 1.3656974423628578 1.135306768744919 1.6433257074045369 1.5261003127963866 1.7251767728500613 1.798114620804406 1.2098719886599618 1.0 12.953817525277831 -6.255893311696882 24.908678393909756 1.537857998258403 1.185144444542926 0.22566160459477969 0.253038178829932 528.657046081836 2374319.548086026 0.07212369529916747 0.0904098076710865 5.547619784351749e-07 6.255893311696882 -0.3527135537154771 HGS(ph)PEFCGILGER ddPTM_A459_Selumetinib_30min_R1 2 HGSPEFCGILGER 13 0 Q15464 Q15464 SHB SH2 domain-containing adapter protein B 1 HGS(1)PEFCGILGER;HGS(1)PEFCGILGER 164.63 0.00023989 23122000.0 5735.6 7149.0 6858.700000000001 6459.0 5799.7 5994.7 5725.0 5714.9 3712.3999999999996 5259.9 True False 5869.228320465179 6311.991756520065 5927.326212142327 5331.056900446205 5275.1181590202 5934.398760752104 5293.158640776058 5563.322287388592 6299.671657031865 5935.059400764714 0.9889081008538765 1.0635094495780082 0.9986970326495147 0.8982314313078846 0.8888062954080153 0.999888688559288 0.8918459417767665 0.9373658984224782 1.0614336321924884 1.0 12.535046753747437 -5.536640262279536 17.927905336473014 0.9479821489279587 1.027432557822639 0.22138028689875877 0.055043577969677106 10.02227599327782 13055.732588686851 0.014843119335585832 0.025787908516512817 2.9064291305395424e-06 5.536640262279536 0.07945040889468036 HGS(ph)PEFCGILGER ddPTM_A459_Selumetinib_30min_R2 3 HGSPEFCGILGER 13 0 Q15464 Q15464 SHB SH2 domain-containing adapter protein B 1 HGS(1)PEFCGILGER;HGS(1)PEFCGILGER;HGS(1)PEFCGILGER 169.98 0.00015852 23384000.0 48544.6 45879.5 42581.0 46906.3 43709.1 30794.2 40196.2 33893.0 26331.1 39783.3 True False 45846.68547143084 49398.31012415603 39841.38481868738 40517.58102211923 38217.97209368815 35035.82152808479 42065.40294725924 33991.62301871181 31598.055752404744 38634.652759573044 1.186672642219381 1.278601115728054 1.0312344481681752 1.0487367719923308 0.9892148463588392 0.9068496550523151 1.088799819401408 0.8798221438728794 0.8178682476853698 1.0 15.237607810910474 -5.475743367155662 0.8106243797848603 0.933169951649427 1.292276541767291 0.6440331236334969 0.0789086925279394 0.710124167890261 0.681757048053675 0.03425310035713557 0.19304727931619634 3.3439258057166587e-06 5.475743367155662 0.35910659011786406 HGS(ph)PTAPICLGSPEFTDQGR ddPTM_A459_Selumetinib_30min_R1 3 HGSPTAPICLGSPEFTDQGR 20 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 HGS(0.781)PT(0.219)APICLGSPEFTDQGR;HGS(0.661)PT(0.339)APICLGSPEFTDQGR;HGS(0.997)PT(0.003)APICLGSPEFTDQGR 151.2 7.893899999999999e-06 14830100.0 4859.5 5565.900000000001 5865.5 5963.5 5931.0 5102.8 5318.6 5149.3 3087.87 4870.65 True False 4972.71689505902 4914.241840483291 5068.9973168852375 4922.086673759244 5394.542097203095 5051.470464971698 4917.4137199705765 5012.72383671632 5239.88986089834 5495.84537164863 0.9048138291356834 0.8941739638153481 0.9223325938234416 0.8956013753863545 0.9815672990058768 0.9191434844638596 0.8947511051417123 0.9120933173584932 0.953427454114578 1.0 12.424125698444387 -14.522878745279506 0.18788171549871627 1.347276537908816 0.9040696636568045 0.5045955985215194 0.025279975555469285 122.03988261142506 1.1866096903077563 15.808663089509162 0.07400233137731967 3.000000000005744e-15 14.522878745279506 -0.44320687425201155 HGS(ph)PTAPICLGSPEFTDQGR ddPTM_A459_Selumetinib_30min_R2 2 HGSPTAPICLGSPEFTDQGR 20 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 HGS(0.879)PT(0.121)APICLGSPEFTDQGR;HGS(0.5)PT(0.5)APICLGSPEFTDQGR 161.51 4.671e-07 13347300.0 41707.0 44839.0 44752.0 42545.0 47869.0 34006.0 34774.0 33259.0 25879.3 40039.0 True False 39389.09190634935 48278.00711989083 41872.70504229348 36750.297605781365 41855.268265710314 38690.01782426727 36391.0599033738 33355.77818367616 31055.883128058027 38882.97003618464 1.0130165434814704 1.2416234427298927 1.076890602835292 0.945151503899558 1.076442160327764 0.9950376164233903 0.9359125568213577 0.8578505744966277 0.7987014134763188 1.0 15.246850801497862 -6.749928926904336 0.7657220821953106 0.8729433196698343 1.1133967147437103 0.4799452994831509 0.0846611159459624 0.5434950834416642 0.6996022614632613 0.05940543982262764 0.058735802208577076 1.7785704525694142e-07 6.749928926904336 0.24045339507387598 HGS(ph)SDISSPR ddPTM_A459_Selumetinib_30min_R1 1 HGSSDISSPR 10 0 Q9BRD0 Q9BRD0 BUD13 BUD13 homolog 1 HGS(0.965)S(0.034)DISSPR 102.53 0.012048 0.0 240.55 285.06 290.28 561.21 397.4 367.36 382.86 458.96 177.28 185.27 True False 246.1543469711797 251.6850426792013 250.86157039390477 463.2052087164291 361.4552401666686 363.6646919361923 353.9805619576454 446.7868898878142 300.83121198109296 209.05120918262284 1.177483488058394 1.2039396646557277 1.2000005710311739 2.215749961588515 1.7290272636065394 1.7395962135693857 1.6932720137888093 2.1372126553810573 1.4390311979410413 1.0 7.70771257793902 -5.694473371535537 15.296471176180365 1.7566811036845469 1.1945506709154996 0.3420382863289555 0.3216365856034828 1.8959602892465564 431.3905413861092 0.0812642302469107 0.14075355301242648 2.0208153330820964e-06 5.694473371535537 -0.5621304327690473 HGS(ph)YEDAVHSGALND ddPTM_A459_Selumetinib_30min_R1 1 HGSYEDAVHSGALND 15 0 F5H282;E7EQR6;P17987 F5H282 TCP1 T-complex protein 1 subunit alpha 1 HGS(0.993)YEDAVHS(0.007)GALND 88.706 0.01735 10242000.0 1789.8 2401.3 2216.3 1918.0 2032.5 1875.8 2352.4 2579.4 1518.1 2300.8 True False 1831.4988576554445 2120.1546796659172 1915.338633264472 1583.0573053190626 1848.6607338670206 1856.9311550901289 2174.9565740718954 2510.985932927984 2576.1048223629136 2596.1300916898513 0.7054726816341089 0.816659645235992 0.7377668166150163 0.6097758006759331 0.7120832425865476 0.7152689154654152 0.8377687162264627 0.967203431355612 0.9922864923483464 1.0 11.342146963042804 -7.586685863819861 2.0881170868144725 0.995613040130535 0.7156102959322391 0.8680856560065768 0.0473065172786716 0.12213385118553827 1.058378428268201 0.032115497140164616 0.01570861109865976 2.5900857122381185e-08 7.586685863819861 -0.28000274419829585 HGS(ph)YEDAVHSGALND ddPTM_A459_Selumetinib_30min_R2 2 HGSYEDAVHSGALND 15 0 F5H282;E7EQR6;P17987 F5H282 TCP1 T-complex protein 1 subunit alpha 1 HGS(0.964)Y(0.009)EDAVHS(0.027)GALND;HGS(0.998)Y(0.001)EDAVHS(0.001)GALND 80.361 0.019401 15330000.0 43411.0 37718.0 55459.0 53377.0 60606.0 49419.0 56303.0 53961.0 42607.0 39847.0 True False 40998.39040800185 40610.84931751471 51890.82831919362 46106.96051953909 52992.132455485575 56226.01866898383 58921.20106227798 54118.017576275546 51129.59053904733 38696.51357506053 1.0594853804717137 1.0494704965795147 1.3409690828746048 1.1915016692680682 1.3694291180184874 1.4529995980108363 1.5226488285045925 1.3985243779469063 1.3212970837765543 1.0 15.239915969832573 -5.284085073554394 1.0896599190008829 1.3704919030116087 0.9843792849509734 0.32968409437336155 0.14260934414508902 0.8690200391518413 1.4566201482462955 0.047019613001440315 0.3189616844620719 5.198941449628426e-06 5.284085073554394 -0.38611261806063535 HGSGADS(ph)DYENTQSGDPLLGLEGK ddPTM_A459_Selumetinib_30min_R1 1 HGSGADSDYENTQSGDPLLGLEGK 24 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QL89 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 HGS(0.467)GADS(0.53)DY(0.001)ENT(0.002)QSGDPLLGLEGK 85.745 6.8346e-05 42797000.0 1402.0 1898.7 1646.7 1497.6 1968.3 1740.0 1965.3 1634.3 805.37 1507.8 True False 1434.663872182889 1676.3993213183178 1423.0871846756324 1236.0722734336946 1790.267612531589 1722.4971797935946 1817.0558387278927 1590.95305504544 1366.6540681025099 1701.3408172157328 0.8432548362242527 0.9853400943273481 0.8364503868216915 0.726528312802454 1.0522686544729973 1.0124351113920163 1.0680140159697862 0.935117196358726 0.8032805974402341 1.0 10.732456459205318 -6.279563779936703 24.941929884295718 0.9814456491240876 0.8568936522921795 0.3315651266844193 0.09044405743063412 1068.4511598393406 1470347.6809244624 0.029892758756416084 0.033958688053377616 5.253348594336647e-07 6.279563779936703 -0.1245519968319081 HGSS(ph)DISSPR ddPTM_A459_Selumetinib_30min_R2 1 HGSSDISSPR 10 0 Q9BRD0 Q9BRD0 BUD13 BUD13 homolog 1 HGS(0.298)S(0.702)DISSPR 77.597 0.036124 1264500.0 5428.3 5444.0 6223.2 5986.1 5827.6 4315.2 5687.9 5460.7 4600.6 5115.5 True False 5126.616817206612 5861.537294781009 5822.806087307844 5170.782853401525 5095.48478859499 4909.579630514554 5952.398620360029 5476.58973293245 5520.848551504245 4967.802223334808 1.0319687835247986 1.17990552587785 1.1721090787304098 1.0408592413589401 1.025702022649056 0.9882800099112701 1.1981955707496497 1.1024170219997407 1.1113261565791934 1.0 12.27839202321771 -5.766155057515185 24.99875680740617 1.0714556131446775 1.1331855691523127 0.13850235431368907 0.06899821850971495 239.45161766860141 1269388.1159879772 0.02014691192825891 0.0310407274907971 1.7133454772065408e-06 5.766155057515185 0.0617299560076352 HGSSDIS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 HGSSDISSPR 10 0 Q9BRD0 Q9BRD0 BUD13 BUD13 homolog 1 HGSSDIS(0.647)S(0.353)PR 122.52 0.0029365 3849500.0 13362.0 11435.0 19913.0 28568.0 40076.0 21025.0 14041.0 16331.0 19305.0 26165.0 True False 12619.39353232407 12312.027730679809 18631.819259635093 24676.989117451227 35041.29459601426 23921.002904052784 14693.93432171367 16378.520506257417 23166.53942676812 25409.548465165743 0.49663981828028736 0.48454334981821956 0.7332605412165304 0.9711699187130858 1.3790601058516563 0.9414178664704088 0.5782839605299466 0.6445813284998326 0.9117257419401769 1.0 14.63308311807121 -5.446583732886946 3.1607373176852898 0.9077855441082965 0.49056854300184816 0.40979910987165435 0.20389926691961074 0.29201470940162333 5.601717106328545 0.06442046479680283 0.1476370689973575 3.5761544492149244e-06 5.446583732886946 -0.4172170011064483 HGSSDISS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 HGSSDISSPR 10 0 Q9BRD0 Q9BRD0 BUD13 BUD13 homolog 1 HGSSDIS(0.272)S(0.728)PR;HGSSDIS(0.12)S(0.879)PR;HGSSDIS(0.171)S(0.829)PR 112.71 0.0080717 4494850.0 3234.92 3933.15 3538.09 4140.200000000001 3611.4300000000003 3567.85 3151.2200000000003 3183.43 1657.23 2533.98 True False 3310.2873419414204 3472.654969528172 3057.6368113372273 3417.191791179344 3284.7767941497546 3531.960668348607 2913.520938338223 3098.9950951620262 2812.198270709764 2859.2410160553923 1.1577503691900348 1.2145373370164665 1.0693875731943514 1.1951394695273714 1.14882822948638 1.235279099773582 1.0189840317685828 1.0838523502427224 0.9835471213928904 1.0 11.481416519885551 -7.277053331988488 24.647541178348934 1.0285835541576343 1.167757219796444 0.6906222485899193 0.048605038797610155 409.6528043167667 646658.2168571472 0.019604525228209903 0.013272239399526431 5.283803619207832e-08 7.277053331988488 0.13917366563880984 HGTDLWIDNMSSAVPNHS(ph)PEKK ddPTM_A459_Selumetinib_30min_R2 4 HGTDLWIDNMSSAVPNHSPEKK 22 1 Q8N6H7;H0YF45;E9PJT7;E9PK28;E9PN48;E9PIY6 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 HGTDLWIDNMSSAVPNHS(1)PEKK;HGTDLWIDNMSSAVPNHS(1)PEKK;HGTDLWIDNMS(0.075)S(0.075)AVPNHS(0.85)PEKK;HGTDLWIDNMSSAVPNHS(1)PEKK 101.49 8.0705e-05 24979700.0 318400.0 278346.0 348649.0 400584.0 404892.0 292866.0 300506.0 311187.0 227620.0 366141.0 True False 300704.602656188 299694.24317654583 326217.3029203294 346023.76815405634 354025.84717959363 333205.6331271496 314480.1244413427 312092.5026502185 273150.360234186 355569.5579814352 0.8456983898264098 0.842856865694316 0.9174500336087873 0.9731535233736819 0.9956584843466206 0.9371039383088772 0.8844405191114876 0.8777255972698126 0.7682051348401642 1.0 18.439772287836206 -10.567011117865299 17.839086401220396 0.9999999497809932 0.8986843064490686 0.19785627604873468 0.06353664593747728 0.0 0.0 0.06759442172962285 0.01639405532316357 2.7101222523314082e-11 10.567011117865299 -0.10131564333192455 HGYIGEFEIIDDHR ddPTM_A459_Selumetinib_30min_R1 2 HGYIGEFEIIDDHR 14 0 I3L3P7;I3L246;H3BN98;P62244 I3L3P7 RPS15A 40S ribosomal protein S15a 0 ; 129.76 0.00057895 107996000.0 12633.5 17462.7 15753.699999999999 14439.7 13677.0 11410.8 9708.8 9174.5 6240.6 8372.8 False True 12927.83596948825 15418.158965811019 13614.434068879898 11918.077461739143 12439.917764870466 11296.017712177449 8976.457399400277 8931.162457024036 10589.842404609708 9447.530437978436 1.368382568794827 1.6319776969260726 1.4410574444037556 1.2615018855963962 1.3167375163844761 1.1956582501992499 0.9501379707987521 0.9453436022943483 1.1209111708218749 1.0 13.205721546218221 -6.53351036106166 0.8818505271561863 0.989772376042606 1.5025830406618206 0.8048565879954876 0.09460703125525416 0.24647770046696946 0.4209195070278556 0.05486462692781928 0.06550570650311607 2.927451029675141e-07 6.53351036106166 0.5128106646192145 HGYIGEFEIIDDHR ddPTM_A459_Selumetinib_30min_R2 4 HGYIGEFEIIDDHR 14 0 I3L3P7;I3L246;H3BN98;P62244 I3L3P7 RPS15A 40S ribosomal protein S15a 0 ;;; 127.02 0.00070527 9150400.0 46957.7 48912.1 57830.0 50762.0 62112.0 40960.9 42172.1 48915.5 36844.1 47570.3 False True 44347.979020566854 52663.50079281013 54109.280760543246 43848.12803066572 54308.93527167478 46602.89216897099 44133.1862124308 49057.83600660306 44213.94951016769 46196.82183651725 0.9599790041294802 1.1399810354742015 1.1712771270722226 0.9491589743085972 1.1755989505915565 1.008790005812321 0.9553294893014652 1.061930973957699 0.957077732893258 1.0 15.495505982740319 -6.969132213580171 24.879966226833993 0.9963617282911238 1.0816396103594772 0.22204120035772112 0.077562120825941 286.35314908030773 230804.87945332073 0.026361969532447346 0.02324886175072591 1.0736625042656238e-07 6.969132213580171 0.0852778820683534 HHAT(ph)NLAVS(ph)KLET(ph)LET(ph)WVMPKK ddPTM_A459_Selumetinib_30min_R2 1 HHATNLAVSKLETLETWVMPKK 22 2 Q86Y38 Q86Y38 XYLT1 Xylosyltransferase 1 4 HHAT(1)NLAVS(1)KLET(1)LET(1)WVMPKK 46.027 0.04291 0.0 3083.2 3220.4 6656.8 8906.8 8419.3 4867.2 2555.8 4417.4 7889.1 6925.6 True False 2911.8480870275084 3467.3943247819207 6228.508735375827 7693.678474912998 7361.592264503015 5537.612619957464 2674.649764221622 4430.253902660064 9467.140439871348 6725.639933130206 0.43294736500594877 0.5155486108766675 0.9260841789484547 1.1439325553267097 1.0945564046984042 0.8233584722071468 0.39767959492544563 0.6587111333208352 1.4076192799493519 1.0 12.715455828826554 -5.22447186903247 4.958017272695957 0.910416590678526 0.46106172052887556 0.32840501315481696 0.26071807079196313 0.2570945316648761 16.1690784511492 0.07271629175675617 0.19580870635249475 5.9638694891934746e-06 5.22447186903247 -0.4493548701496504 HHEDNLLR ddPTM_A459_Selumetinib_30min_R1 2 HHEDNLLR 8 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 ; 170.3 0.00025578 10160700.0 987.6300000000001 1269.1399999999999 1615.6399999999999 1624.6100000000001 1676.19 1498.26 1225.1100000000001 1166.58 858.15 1126.76 False True 1010.639857406553 1120.5484987928205 1396.2449620752654 1340.9023612066749 1524.5789104553808 1483.188864711237 1132.69896635828 1135.6385088141149 1456.2178732038292 1271.3906215718252 0.7949090077108599 0.8813565868587908 1.0982029742748003 1.0546737866832083 1.199142800479791 1.1665878602105504 0.8909134196364605 0.8932254883319184 1.1453740876297336 1.0 10.312191636187935 -5.1044925988099195 3.7137608056169458 1.0550372745328351 0.8087181800849015 0.44017088564711315 0.1001236935144303 0.231536019391824 5.624527111605823 0.02843116467612397 0.09453879447667772 7.861535885611864e-06 5.1044925988099195 -0.24631909444793365 HHFETLTES(ph)PCR ddPTM_A459_Selumetinib_30min_R1 4 HHFETLTESPCR 12 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 HHFETLT(0.033)ES(0.967)PCR;HHFETLT(0.001)ES(0.999)PCR;HHFET(0.028)LT(0.043)ES(0.929)PCR;HHFET(0.002)LT(0.022)ES(0.977)PCR 181.75 6.871899999999999e-05 121453000.0 14485.7 17513.9 14654.399999999998 13154.3 15205.099999999999 13243.300000000001 14905.7 15104.599999999999 7064.5 13882.7 True False 14823.188625734432 15463.36444600879 12664.412970857227 10857.148441792773 13829.80138967844 13110.084425954314 13781.351048352077 14703.976941344517 11987.940529334564 15664.679773949374 0.9462809862468842 0.9871484555799619 0.8084693178291688 0.6930973756545215 0.8828652477580571 0.8369200401885396 0.8797722805205821 0.9386707646457911 0.765284749023131 1.0 13.935227657189646 -9.65401500120095 13.418702971247715 0.9999999992107453 0.8600726804269568 0.19998915664936456 0.08410101958978508 0.0 0.0 0.0858369861519346 0.020818527087594522 2.218119801199391e-10 9.65401500120095 -0.1399273187837885 HHFETLTES(ph)PCR ddPTM_A459_Selumetinib_30min_R2 3 HHFETLTESPCR 12 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 HHFET(0.01)LT(0.025)ES(0.965)PCR;HHFET(0.026)LT(0.18)ES(0.794)PCR;HHFET(0.029)LT(0.363)ES(0.608)PCR 155.37 0.00028139 25644000.0 77691.0 88329.0 103822.5 94368.0 104591.0 69896.9 66825.0 78905.1 55112.2 95142.0 True False 73373.24524171457 95103.55027750044 97142.67338339095 81514.91560611989 91451.3435245964 79524.56351411581 69932.4949112254 79134.70077755742 66136.17996352914 92395.00325139695 0.794125684936379 1.0293148647739514 1.051384490123087 0.8822437657621646 0.9897866800844961 0.8607019937835595 0.7568861134291703 0.8564824719172349 0.7157982318976671 1.0 16.495527211933712 -6.9118337515578405 4.944208500737924 0.8187679565578935 0.9551668502839885 0.2416533103360523 0.09801221795126787 0.2585764567463132 10.858916957873396 0.03386370493617222 0.029688301484974738 1.225085073533956e-07 6.9118337515578405 0.13639889372609504 HHIIGDNPNS(ph)SDYPAPR ddPTM_A459_Selumetinib_30min_R2 1 HHIIGDNPNSSDYPAPR 17 0 Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9;Q8NFP9-2;Q8NFP9-3 Q5T321 NBEA Neurobeachin 1 HHIIGDNPNS(0.972)S(0.026)DY(0.002)PAPR 108.66 0.0023179000000000003 10057000.0 26402.0 11667.0 24476.0 17810.0 16782.0 14247.0 28487.0 20535.0 22086.0 18246.0 True False 24934.682535580007 12561.82138468223 22901.240807453843 15384.247276036342 14673.695127016457 16209.39492861071 29811.70194591962 20594.753450247743 26503.817134400444 17719.190571198706 1.4072134071468012 0.7089387821755574 1.2924541172144848 0.868225171698438 0.8281244602034764 0.9147931934858209 1.6824528087855457 1.1622852278434808 1.4957690661942837 1.0 14.113025081321087 -7.229763521642321 24.9930897107452 1.348650665078672 0.9889540545980027 0.27814472402189816 0.26091384538266066 776.9468599703818 613032.4532195749 0.09344977322214673 0.07237946819156689 5.891643748317012e-08 7.229763521642321 -0.35969661048066937 HHPDLIFCR ddPTM_A459_Selumetinib_30min_R1 1 HHPDLIFCR 9 0 Q7RTV0 Q7RTV0 PHF5A PHD finger-like domain-containing protein 5A 0 106.68 0.018302 10732000.0 1289.9 1420.4 1683.2 1359.7 1639.1 1385.3 1342.9 1560.1 794.83 930.22 False True 1319.9521602915183 1254.0989076739547 1454.6306851557822 1122.2539197300985 1490.8436944066086 1371.3651397517622 1241.603971825007 1518.7210800810078 1348.7684579136512 1049.6227981101065 1.2575490573072081 1.194809135178863 1.3858604136408916 1.0691973552315819 1.420361388006187 1.3065313960605347 1.182904919806021 1.446920820332346 1.2850030128367735 1.0 10.035655245823701 -10.428326723003435 4.327993680848152 0.9999948960676803 1.2839411153295994 0.3736253943700918 0.11001641365880618 73475493.54821597 167456945.7755739 5996.367810866002 0.026247505660040003 3.729694644932762e-11 10.428326723003435 0.2839462192619191 HHTAAFEER ddPTM_A459_Selumetinib_30min_R1 2 HHTAAFEER 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 128.6 0.0060195 3129500.0 415.81 462.21000000000004 521.91 504.99 693.91 475.06 592.3499999999999 237.226 52.679 344.28999999999996 False True 425.497563974584 408.0942383244006 451.03748864642006 416.8029763363258 631.1459630197605 470.28132771996854 547.6685625962789 230.93399586135308 89.39241547806859 388.48297516859316 1.095279822210812 1.0504816540475077 1.1610225350304724 1.0728989504763815 1.6246425284038688 1.2105583970980367 1.409762068359888 0.5944507497687196 0.23010639124989768 1.0 8.601707565298243 -7.773390169099695 24.06378930776163 0.5592082330207544 1.2305208192641792 0.5861405464471099 0.2391828247394483 94.8204047847562 190923.23115683952 0.12801112339474963 0.062326619335491835 1.6850385106982365e-08 7.773390169099695 0.6713125862434248 HHTAAFEER ddPTM_A459_Selumetinib_30min_R2 3 HHTAAFEER 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ;; 104.42 0.020176 3703300.0 2112.3 954.89 2568.87 2697.43 4011.55 1010.6 1151.0 3800.1299999999997 1228.7 1665.88 False True 1994.9068222068652 1028.126992544717 2403.591700974179 2330.035380673707 3507.58322528798 1149.800976686599 1204.5237806632317 3811.187749154613 1474.474332746437 1617.7817159239548 1.2331124790018566 0.6355165115446545 1.4857330116389829 1.4402656166397372 2.168143693776829 0.7107268955811628 0.7445527222906575 2.355810868450785 0.9114173551555617 1.0 10.659801245582853 -5.278386705700537 24.420383426217317 1.3881946704749344 0.934314453427354 0.0825732250472021 0.546501286283781 1254.9921389209042 1808390.8702150902 0.1423235230087231 0.29759678168547876 5.267606128889561e-06 5.278386705700537 -0.4538802170475804 HHYEQQQEDLAR ddPTM_A459_Selumetinib_30min_R1 2 HHYEQQQEDLAR 12 0 A0A5F9ZHX5;K7EMY3;Q8TDI0;Q12873-2;Q12873;Q12873-3;Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8Y5Z7;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0 A0A5F9ZHX5;Q12873-2;Q14839-2 CHD5;CHD3;CHD4 Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3;Chromodomain-helicase-DNA-binding protein 4 0 ; 168.83 5.9562e-05 3999600.0 4156.37 5062.469999999999 5423.29 5819.63 4673.56 4221.07 4133.32 4566.860000000001 2269.5099999999998 3698.01 False True 4253.205334111836 4469.753658921549 4686.837005999584 4803.340868484866 4250.837323184037 4178.609868224914 3821.5403446449754 4445.732037548073 3851.1927115478925 4172.685605167761 1.0192968597596601 1.0711934906828053 1.1232183417305774 1.1511389361652493 1.0187293569205134 1.0014197722085305 0.9158467007224551 1.0654366176167576 0.9229530034034416 1.0 12.026760508174378 -6.481071050842092 4.555392495128711 0.9831507041858205 1.0922199048730417 0.5099431049337722 0.05084522675496422 0.17763681082211952 8.326809252094742 0.016471841266727044 0.01810376711158529 3.303154967993821e-07 6.481071050842092 0.10906920068722115 HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_A459_Selumetinib_30min_R1 2 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;P06733-2;K7EM90;A0A2R8YEM5 P06733 ENO1 Alpha-enolase;Enolase 0 ; 149.09 6.5894e-20 61406000.0 10245.7 10103.4 12493.9 13377.3 10929.7 9857.9 9411.3 8928.0 5938.8 8162.0 False True 10484.404875338243 8920.48923105677 10797.297004080217 11041.20567802122 9941.110564795263 9758.738476257062 8701.398063918905 8691.200437768877 10077.709847209588 9209.672204612556 1.1384123823741796 0.968600079662884 1.1723866782872596 1.198870647371289 1.0794206725203939 1.059618438034039 0.9448108326332084 0.9437035591142964 1.0942528271703618 1.0 13.16893409274897 -6.931763267010842 2.810755894007619 0.9916994497159628 1.112687972031985 0.37629771419891134 0.06991044830769061 0.298718790653718 4.7869026045314484 0.02854412732409512 0.02401447969906043 1.1701370564048884e-07 6.931763267010842 0.1209885223160223 HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_A459_Selumetinib_30min_R2 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;P06733-2;K7EM90;A0A2R8YEM5 P06733 ENO1 Alpha-enolase;Enolase 0 135.06 3.6942e-18 31790000.0 77395.0 46883.0 53287.0 77511.0 83605.0 55926.0 54927.0 53384.0 37967.0 61929.0 False True 73093.69573673267 50478.77534739496 49858.57243449887 66953.86808606706 73101.79246181689 63629.29885431893 57481.21433578568 53539.33860180304 45561.460886615096 60140.948859134274 1.21537317124705 0.8393411860798766 0.8290286964258013 1.1132825363778416 1.2155078004013584 1.0580029091884677 0.9557749823738501 0.8902310259055952 0.7575780188192885 1.0 15.87606000940963 -7.585182346855912 2.8869000589384695 0.8666666799464496 1.0357934835927356 0.22341523196514068 0.13516570056889057 0.43946995907129666 7.4070768748860925 0.07845465267461682 0.04165498892405917 2.59906806553309e-08 7.585182346855912 0.16912680364628596 HIAEDADR ddPTM_A459_Selumetinib_30min_R2 2 HIAEDADR 8 0 P09493-3;P09493-9;A0A0S2Z4G6;P09493-4;P09493-10;P09493;Q6ZN40;P09493-2;H7BYY1;H0YKX5;P09493-8;P09493-7;P09493-5;H0YKJ4;F5H7S3;A0A494BZZ2;H0YK48;B7Z596;P09493-6;A0A494C0V8;H0YL42 P09493-3 TPM1 Tropomyosin alpha-1 chain 0 ; 101.25 0.024142 9165600.0 2536.3 2613.5 2937.0 1849.1399999999999 4405.0 3516.6 8714.2 20208.3 2008.5 12609.3 False True 2395.342599613347 2813.9470462729946 2748.036617563816 1597.2839420555777 3851.604518800351 4000.9797294835657 9119.427566859722 20267.10280733585 2410.2561221789056 12245.236746104127 0.19561423345901705 0.22979931745037627 0.22441678136097412 0.130441246271842 0.3145389998299343 0.32673763786204413 0.7447326463296927 1.6551009365975642 0.19683213743872602 1.0 13.579933046397736 -7.313365548381567 3.4189362693719034 0.9808974410397556 0.22754983063467898 0.49201652953035724 0.3326717827931622 0.19061903754376455 4.519195220379203 0.13908961368708522 0.0923048786348066 4.8599796595834315e-08 7.313365548381567 -0.7533476104050767 HIAEEADR ddPTM_A459_Selumetinib_30min_R1 3 HIAEEADR 8 0 J3KN67;A0A2R2Y2Q3;A0A494C0P6;P06753;P06753-7;P06753-2;A0A087WWU8;P06753-5;P06753-3;P06753-6;P06753-4;P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A2R8YH90;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YHD2;A0A2R8YEU4;A0A5F9UN72 J3KN67;P06753-2;P67936 TPM3;TPM4 Tropomyosin alpha-3 chain;Tropomyosin alpha-4 chain 0 ;; 160.63 0.00060568 20283000.0 3278.74 3580.68 3345.1000000000004 3014.4799999999996 2367.91 3322.8 2257.25 3384.37 4562.41 2712.8100000000004 False True 3355.1282626825428 3161.4523209870313 2890.8537933190387 2488.0576567978123 2153.7329585884654 3289.3756488610097 2086.983815177598 3294.60551361692 7742.076544757775 3061.0255885071047 1.096079782958912 1.0328081976370886 0.9444069347780066 0.8128183136199345 0.7035984823762497 1.074599200088776 0.6817923453542388 1.0763077335866815 2.529242674032552 1.0 11.579799389722353 -8.025924484820852 23.69126388067463 1.7773400012958833 0.9058799870922489 0.45868163401798057 0.36764737069867326 300.64324816514755 274741.7794700648 0.2225310021752877 0.08492746111806501 9.420533866438866e-09 8.025924484820852 -0.8714600142036344 HIAEEADR ddPTM_A459_Selumetinib_30min_R2 5 HIAEEADR 8 0 J3KN67;A0A2R2Y2Q3;A0A494C0P6;P06753;P06753-7;P06753-2;A0A087WWU8;P06753-5;P06753-3;P06753-6;P06753-4;P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A2R8YH90;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YHD2;A0A2R8YEU4;A0A5F9UN72 J3KN67;P06753-2;P67936 TPM3;TPM4 Tropomyosin alpha-3 chain;Tropomyosin alpha-4 chain 0 ;;;; 166.68 0.00034799 101737000.0 55702.5 55393.130000000005 43751.4 40438.9 52459.1 47901.0 78870.4 126089.0 63808.2 100007.84 False True 52606.77804477486 59641.604954014125 40936.48255692259 34931.05205900649 45868.718867695665 54498.927948015815 82538.02987873268 126455.89811484235 76571.62295007022 97120.35380762645 0.541665840190173 0.6140999555268375 0.4215026094119111 0.3596676771606191 0.47228739465417585 0.5611483670659388 0.8498530600724739 1.3020535156340451 0.7884199341133101 1.0 16.56748605686358 -7.335772488428135 2.9473536799226254 1.0393124932709887 0.48369540291768126 0.7667065322041517 0.13480184017052246 0.12035702018130995 2.047899404622228 0.061344732536960135 0.039475879408655476 4.615593058897614e-08 7.335772488428135 -0.5556170903533075 HIAFT(ph)PESQR ddPTM_A459_Selumetinib_30min_R2 2 HIAFTPESQR 10 0 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6;Q5H9R7-3 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 HIAFT(1)PESQR;HIAFT(0.999)PES(0.001)QR 96.334 0.029567000000000006 9867100.0 30401.0 22972.0 31054.0 31475.0 37267.0 28209.0 33760.0 34212.0 30880.0 24755.0 True False 28711.434124845404 24733.87853337793 29056.01944903872 27188.050702596513 32585.186288792887 32094.533694193797 35329.9068941709 34311.551255898485 37056.86285929032 24040.25882878569 1.1943063645582082 1.0288524224939586 1.2086400423545849 1.1309383520464293 1.3554424068752349 1.3350327849117813 1.469614247741253 1.4272538203629488 1.5414502449082874 1.0 14.553164808418655 -6.3123972549459575 2.6726278521067344 1.387960967477105 1.1323684686068105 0.33319890924869966 0.14369635797363314 0.2805012489377877 3.955239471430065 0.04495597831576174 0.054677094460252186 4.870827451967085e-07 6.3123972549459575 -0.25559249887029445 HIALS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 HIALSPR 7 0 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 HIALS(1)PR;HIALS(1)PR 102.07 0.012911 4999900.0 14667.0 12223.0 13032.900000000001 13760.5 15932.5 10397.9 12745.0 14217.6 11800.8 13978.9 True False 13851.86685665298 13160.46479686046 12194.377403148608 11886.296161813474 13930.916911642813 11830.116342261614 13337.667753738398 14258.970862149614 14161.289741901328 13575.292835455957 1.0203733373967938 0.9694424242906902 0.8982773006044722 0.8755830394147255 1.0261964202538627 0.8714446521082557 0.9824957675242976 1.0503619358330176 1.0431664284187567 1.0 13.728695698588549 -7.554828993855272 5.593548807024464 1.0329710126865346 0.9419951641528064 0.3644528097348525 0.051785516112668545 0.1932528522975637 16.651860930666235 0.02476267791438079 0.01434228337627835 2.7872184371268823e-08 7.554828993855272 -0.0909758485337282 HIDCAYVYQNEHEVGEAIQEK ddPTM_A459_Selumetinib_30min_R1 2 HIDCAYVYQNEHEVGEAIQEK 21 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 0 ; 109.77 6.4427e-05 66073000.0 13049.6 15277.5 14993.0 15506.8 16091.3 12724.5 14854.4 12753.3 6427.1 10773.0 False True 13353.630289898594 13488.803197682937 12957.032950653895 12798.828478686979 14635.844756149749 12596.503082921601 13733.920648653952 12415.041055443315 10906.319283188648 12155.819487906285 1.0985380544013508 1.1096580704495345 1.0659119250285618 1.052897214492237 1.2040195867264085 1.0362528906795423 1.129822687998757 1.0213248944503435 0.8972097104633091 1.0 13.569359535876684 -7.987284031237024 4.582353345678877 0.9496659412668104 1.097925635507729 0.6005128067681201 0.04968302004328765 0.12068944442582853 6.446460915910784 0.029904276208989604 0.012503899261469458 1.0297124619537977e-08 7.987284031237024 0.14825969424091856 HIDFSLR ddPTM_A459_Selumetinib_30min_R1 2 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 ; 162.31 0.00069791 38945000.0 3088.2 3713.1000000000004 3756.1 4317.3 3976.8999999999996 3987.8999999999996 3596.2 3366.5 1709.8899999999999 3069.6 False True 3160.1490514088414 3278.368525826641 3246.042250780439 3563.364600758077 3617.1900971787213 3947.785346723493 3324.935738682768 3277.2094840668624 2901.558444575537 3463.61306043601 0.9123851297093308 0.9465169661341877 0.9371838580524978 1.0287998510750245 1.0443401251996025 1.1397882147454814 0.9599616587264557 0.9461823324035847 0.8377259220203657 1.0 11.7580620522063 -7.712723510360342 3.4131876999896567 0.9158292851799047 1.0019845202976112 0.16674945180947265 0.0716114718695048 0.41046750376065744 9.706558069427286 0.04281215763132374 0.021401123987016154 1.9376551619228582e-08 7.712723510360342 0.08615523511770651 HIDFSLR ddPTM_A459_Selumetinib_30min_R2 2 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 ; 177.71 1.7438e-06 3639100.0 7337.4 6177.700000000001 9877.4 8502.7 9110.7 8042.099999999999 6569.8 7423.8 5857.0 7723.2 False True 6929.616681939433 6651.509725563681 9241.898837699979 7344.617592024379 7966.132415308599 9149.8262760848 6875.308717811727 7445.402028923746 7028.563658253348 7500.211148716531 0.923922879574565 0.8868429959737756 1.2322184875130473 0.979254776484689 1.0621210866405806 1.2199424915724615 0.9166820215439214 0.9926923230951752 0.9371154383375069 1.0 12.872715496126373 HIDLVEGDEGR ddPTM_A459_Selumetinib_30min_R1 1 HIDLVEGDEGR 11 0 P19367-4;P19367-2;P19367;P19367-3 P19367-4 HK1 Hexokinase-1 0 98.182 0.025995 2796000.0 1876.4 2302.6 2529.4 3089.7 2636.4 2470.3 2221.2 2314.5 1217.0 1939.5 False True 1920.1164691611796 2033.0105215503027 2185.921372999665 2550.1418958520885 2397.938085494225 2445.45102485294 2053.6530957016207 2253.1119414444515 2065.1601138368137 2188.453717329828 0.877385002002212 0.9289712208448326 0.9988428613727994 1.165271111588123 1.09572254898769 1.1174332842810488 0.9384037137451186 1.0295451640592674 0.9436617724575656 1.0 11.09569615802228 -5.265029230934369 2.99431206210245 1.0454437993840087 0.8923846696471976 0.3850384658068625 0.0689390666019361 0.27499001100952947 4.946397107519841 0.01991590329087957 0.05863726773604793 5.432137683283739e-06 5.265029230934369 -0.15305912973681102 HIDSAHLYNNEEQVGLAIR ddPTM_A459_Selumetinib_30min_R1 2 HIDSAHLYNNEEQVGLAIR 19 0 Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 Q04828;A0A0A0MSS8 AKR1C1;AKR1C3 Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 ; 112.34 0.00032513 21147500.0 5108.200000000001 5314.8 5248.1 4756.4 7030.2 4036.4 5565.1 5063.1 1944.9 3405.1 False True 5227.211121173061 4692.5407452165155 4535.436845749799 3925.784028685915 6394.319651282617 3995.797480757971 5145.320026512285 4928.8101407333825 3300.3532501242526 3842.1777534827506 1.3604813354704486 1.221323178232176 1.180433893678824 1.0217601268258292 1.6642435778736346 1.0399824623251674 1.339167617075576 1.28281679218658 0.8589798447332739 1.0 11.907708549666554 -8.2563499344517 24.763091898845843 0.9294899050680338 1.259917935712575 0.3707635601093393 0.17413743857179945 352.9228547083402 1717198.1699634 0.12050440693055002 0.04240751766455836 5.541790011473208e-09 8.2563499344517 0.3304280306445412 HIDSSPYSPAYLS(ph)PPPESSWR ddPTM_A459_Selumetinib_30min_R2 2 HIDSSPYSPAYLSPPPESSWR 21 0 Q53ET0;H0YDQ8 Q53ET0 CRTC2 CREB-regulated transcription coactivator 2 1 HIDSSPYSPAY(0.001)LS(0.999)PPPESSWR;HIDSSPYSPAYLS(1)PPPESSWR 135.66 2.3774e-05 6351600.0 21749.2 17299.3 27158.0 28892.0 32236.0 19401.8 16960.2 20414.6 22788.6 27016.0 True False 20540.466532945877 18626.100683983317 25410.683847394663 24956.859758520022 28186.225486503532 22074.22183799531 17748.882905998737 20474.00310618104 27346.956766684685 26235.9778840022 0.7829121759349686 0.7099449758013736 0.9685434238336215 0.951245647060019 1.0743348546459375 0.8413721773814808 0.676509295154628 0.7803788826436459 1.0423456250647292 1.0 14.67925894357661 -5.2552923498287 24.80960436476938 0.9045725208924694 0.7464285652268968 0.24796022275719742 0.11716272162096718 722.6561614854479 2916638.8663955536 0.032832143099449616 0.08222384314618865 5.555301704861644e-06 5.2552923498287 -0.1581439556655726 HIEDTGST(ph)PSIGENDLK ddPTM_A459_Selumetinib_30min_R1 1 HIEDTGSTPSIGENDLK 17 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 HIEDTGS(0.02)T(0.656)PS(0.323)IGENDLK 157.47 9.5991e-05 4795900.0 1225.0 1759.2 2061.8 1646.0 1561.0 1436.8 1328.5 1437.8 995.84 1211.8 True False 1253.5401165649348 1553.2320461701077 1781.81888465672 1358.5569992467035 1419.8078256169338 1422.3470965100212 1228.2901754185139 1399.6648733673942 1689.8677467241182 1367.3463339315722 0.9167685504817152 1.1359463272951869 1.3031218502874853 0.9935719762676393 1.0383673765625403 1.0402244560968716 0.8983021674448595 1.0236359572069027 1.2358739733957456 1.0 10.417162992830448 HIEDTGSTPS(ph)IGENDLK ddPTM_A459_Selumetinib_30min_R2 1 HIEDTGSTPSIGENDLK 17 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 HIEDTGS(0.002)T(0.011)PS(0.986)IGENDLK 75.533 0.014547999999999997 5644300.0 39036.0 32102.0 33891.0 44340.0 40321.0 35418.0 41636.0 29428.0 26797.0 36829.0 True False 36866.53539348918 34564.12017580087 31710.489957730795 38300.815509233624 35255.51550568647 40296.50800740746 43572.15650016883 29513.63060793235 32157.14877073842 35765.65107676625 1.0307804914374419 0.966405451465529 0.8866185572763212 1.0708826585325115 0.9857367178921239 1.126681796478871 1.2182682319034805 0.8251948369284607 0.8991070427242425 1.0 15.126287084088323 -7.801312076890204 24.99999684616353 0.8966132375339914 1.0343254517053537 0.29118557794663646 0.09396850664584873 213.3554432257686 133770.14022739028 0.054570642992153334 0.026215430818163677 1.580112188520074e-08 7.801312076890204 0.13771221417136237 HIEPELAGRDS(ph)PIR ddPTM_A459_Selumetinib_30min_R1 2 HIEPELAGRDSPIR 14 1 P86791;P86790 P86791 CCZ1;CCZ1B Vacuolar fusion protein CCZ1 homolog;Vacuolar fusion protein CCZ1 homolog B 1 HIEPELAGRDS(1)PIR;HIEPELAGRDS(1)PIR 163.34 0.00014783 48049000.0 4091.6000000000004 5177.799999999999 3751.1 3139.9 4448.3 3704.6 4783.8 5115.2 2349.21 4869.7 True False 4186.926319132315 4571.580768906083 3241.7212233174046 2591.5754082227954 4045.9520504111515 3667.335087507674 4422.954114540523 4979.528279488727 3986.437790490205 5494.773429894853 0.7619834325384434 0.8319871287201671 0.5899644934731072 0.4716437249483438 0.7363273667297642 0.6674224395777956 0.8049383966365216 0.906229955251133 0.7254962995929186 1.0 12.42384427933867 -7.378014442409712 3.1361239532236627 0.8623553552175823 0.6721403291487 0.39873496309395695 0.11169441930419739 0.3057042805832252 5.703864075567953 0.05522441710891428 0.03487674217842865 4.18779638420859e-08 7.378014442409712 -0.1902150260688823 HIEPELAGRDS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 4 HIEPELAGRDSPIR 14 1 P86791;P86790 P86791 CCZ1;CCZ1B Vacuolar fusion protein CCZ1 homolog;Vacuolar fusion protein CCZ1 homolog B 1 HIEPELAGRDS(1)PIR;HIEPELAGRDS(1)PIR;HIEPELAGRDS(1)PIR;HIEPELAGRDS(1)PIR 161.48 0.00015557 58644900.0 88254.0 63835.7 95226.0 86802.0 97070.0 79895.9 94198.0 94217.4 83020.0 73696.4 True False 83349.1959887538 68731.69292587285 89099.26283422927 74979.4178581979 84875.19878318967 90900.83500223128 98578.39364979588 94491.5570354698 99626.31977261265 71568.59344575726 1.164605757578919 0.9603610971894462 1.244949195512117 1.0476581171743407 1.1859279985363644 1.2701218596831327 1.3773973876475536 1.3202936160410383 1.3920396500193999 1.0 16.127039005860922 -6.636670583331671 2.741570565781346 1.3010415083745899 1.1041603359624785 0.27547762170202317 0.12384971368015912 0.29695221522848064 4.52035235748915 0.041860655190753514 0.04173761594002573 2.3084975430689384e-07 6.636670583331671 -0.19688117241211134 HIGYDDSSK ddPTM_A459_Selumetinib_30min_R1 1 HIGYDDSSK 9 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 120.31 0.006279600000000001 0.0 4532.0 5489.0 5730.7 5243.8 5003.8 5248.8 5155.1 4994.5 3263.4 3985.0 False True 4637.586782263087 4846.345328233132 4952.502416481843 4328.068768317047 4551.20717349264 5196.001837529091 4766.246656605181 4862.029635577587 5537.751450694378 4496.513567187089 1.0313739106905997 1.077800668410946 1.1014094236526477 0.9625387989265165 1.0121635586078674 1.1555623617921351 1.0599871623620676 1.0812887724965001 1.2315656047622385 1.0 12.134591106368703 -6.75050867373957 24.99933828249612 1.1079054817961327 1.0387559965103834 0.20966034853947257 0.0665070489355216 355.94881566520684 814079.3023432251 0.02197267836940418 0.021764508412176375 1.7761977936702307e-07 6.75050867373957 -0.06914948528574927 HIGYDDSSK ddPTM_A459_Selumetinib_30min_R2 1 HIGYDDSSK 9 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 99.013 0.026958 5392800.0 71981.0 72773.0 74395.0 79496.0 83358.0 51503.0 65624.0 61648.0 59914.0 78954.0 False True 67980.58418277356 78354.45509792396 69608.50669515156 68668.5076617508 72885.82281002488 58597.07075231535 68675.64603148912 61827.38547362422 71898.47413703111 76674.392872872 0.8866139220102728 1.0219116469280367 0.9078455542590881 0.8955859327846892 0.9505888482334818 0.7642326017432013 0.8956790325729086 0.8063628958384518 0.937711684998152 1.0 16.22645721746477 -5.894781754494052 1.4475574837999914 0.8754130246527484 0.9521220367594951 0.0646128414815289 0.07229811328719454 0.7891262980039772 3.3591237335362973 0.02368889820987975 0.0470820513312148 1.274143213882809e-06 5.894781754494052 0.07670901210674674 HIISATSLST(ph)SPTELGSR ddPTM_A459_Selumetinib_30min_R1 1 HIISATSLSTSPTELGSR 18 0 Q5JSZ5;A0A1W2PQP5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 HIISAT(0.001)S(0.006)LS(0.002)T(0.461)S(0.461)PT(0.068)ELGSR 84.195 0.019012 4004200.0 1103.5 1486.2 1483.2 1731.6 1770.5 1053.1 1685.9 1113.5 758.18 1134.3 True False 1129.2094029627801 1312.195013084364 1281.7895866344204 1429.2085661577107 1610.3585876071634 1042.506770138296 1558.7312056741239 1083.9663628422543 1286.5760847237425 1279.8984540176446 0.8822648386035264 1.0252336886300155 1.0014775645761893 1.1166577798975978 1.2581924624974687 0.8145230325623348 1.217855370307866 0.8469159091798628 1.0052173128931725 1.0 10.321813637311896 -10.252639754249895 11.825849659715226 0.999995269017002 1.0231138142674872 0.0007090106134259866 0.1404008097823983 0.0 0.0 0.13094407227916055 0.03175860241502897 5.5893363599024654e-11 10.252639754249895 0.02311854525048518 HIISATSLSTS(ph)PTELGSR ddPTM_A459_Selumetinib_30min_R1 3 HIISATSLSTSPTELGSR 18 0 Q5JSZ5;A0A1W2PQP5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 HIISATSLST(0.022)S(0.977)PT(0.001)ELGSR;HIISAT(0.011)S(0.011)LS(0.02)T(0.216)S(0.742)PTELGSR;HIISATS(0.013)LS(0.021)T(0.21)S(0.72)PT(0.036)ELGSR 271.41 4.357e-54 65795800.0 8559.2 9516.5 10792.999999999998 10215.7 11004.8 9144.699999999999 10315.4 9215.7 3381.73 6591.5 True False 8758.61270669599 8402.303755899175 9327.369881705294 8431.719767438977 10009.417783055249 9052.712620723263 9537.301073023818 8971.269699187575 5738.548818213115 7437.583231647103 1.177615420749562 1.1297088710412222 1.25408611792297 1.1336639207695582 1.3457890112025805 1.2171578238215532 1.2823118445844564 1.2062076375850959 0.7715609546116332 1.0 12.860618192805344 -8.246947765564972 24.200354421175597 0.8857805110345907 1.2200780111176048 0.7326225281404877 0.08035111990534372 212.72435799146646 355242.41230928194 0.05267091117751642 0.019687315611569924 5.663073971292937e-09 8.246947765564972 0.3342975000830142 HIISATSLSTS(ph)PTELGSR ddPTM_A459_Selumetinib_30min_R2 4 HIISATSLSTSPTELGSR 18 0 Q5JSZ5;A0A1W2PQP5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 HIISATSLST(0.001)S(0.992)PT(0.007)ELGSR;HIISATS(0.002)LS(0.021)T(0.243)S(0.721)PT(0.013)ELGSR;HIISATSLST(0.019)S(0.98)PT(0.001)ELGSR;HIISATSLST(0.023)S(0.976)PT(0.001)ELGSR 329.08 4.0264999999999975e-144 66638200.0 188995.0 146211.0 209902.0 236687.0 231315.0 162207.0 150938.0 161491.0 162457.0 204044.0 True False 178491.41450692943 157424.91355753603 196397.1338440175 204449.8222921508 202255.1417176625 184549.5418814597 157956.91607797306 161960.91207372586 194952.93942784047 198152.71955001997 0.9007770113489287 0.7944625434111038 0.9911402391549851 1.0317790376858353 1.020703335169755 0.9313500329470553 0.7971473540038887 0.8173539704199813 0.9838519494991247 1.0 17.596253242168665 -9.99426344690017 15.149893160935374 1.0000321704909099 0.9173421451092523 0.0744696374614986 0.08582744070006622 0.0 0.0 0.09200434047319497 0.022314330222721935 1.0132965245700652e-10 9.99426344690017 -0.0826900253816576 HIKEEPLS(ph)EEEPCTS(ph)TAIASPEK ddPTM_A459_Selumetinib_30min_R1 1 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 HIKEEPLS(0.996)EEEPCT(0.125)S(0.329)T(0.263)AIAS(0.288)PEK 78.043 0.0014429 146530000.0 1197.5 2358.3 2465.6 2845.3 1582.8 1773.4 1446.0 1728.3 976.02 1574.3 True False 1225.3994200706206 2082.1891396560745 2130.785062571349 2348.4217678958967 1439.6360194660363 1755.5612061183683 1336.9270558187204 1682.4598696904077 1656.2346543196438 1776.376739980586 0.6898308182553735 1.1721551474935608 1.1995119135564882 1.322029114117742 0.810433950785558 0.9882820274586317 0.7526145922364034 0.9471300945478465 0.9323667761703212 1.0 10.794721870438927 -6.2852401760835335 24.992828231216773 0.8990254508474654 1.1087320503374294 0.23326426612650486 0.16855571542520142 1092.0707783215437 1146762.218438245 0.05266825292759841 0.059751144537049425 5.185132084059243e-07 6.2852401760835335 0.20970659948996395 HIKEEPLS(ph)EEEPCTST(ph)AIASPEK ddPTM_A459_Selumetinib_30min_R1 2 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 HIKEEPLS(0.999)EEEPCT(0.038)S(0.099)T(0.511)AIAS(0.353)PEK;HIKEEPLS(1)EEEPCT(0.026)S(0.205)T(0.455)AIAS(0.314)PEK 81.48899999999998 0.0016595 72550000.0 6571.0 8469.0 9637.599999999999 10898.0 6915.8 9072.1 7533.700000000001 6919.0 4302.9 6216.9 True False 6724.0915150597475 7477.445542868712 8328.866855547383 8994.86888079622 6290.267111083659 8980.842910807742 6965.426943583337 6735.485643920574 7301.707028618256 7014.899672734104 0.9585442171319021 1.0659376315719036 1.187310901668413 1.282251963739121 0.8967009372255192 1.280252509628181 0.99294747872973 0.9601684925160696 1.040885453714888 1.0 12.776206755195213 -7.415390948539989 18.774795622681385 0.9950038463935414 1.1132741298360602 0.18188192850978602 0.11762502626248289 7.263776686060388 1255.2343709916727 0.048640650222590995 0.03279316414970229 3.842457312715729e-08 7.415390948539989 0.11827028344251878 HIKEEPLS(ph)EEEPCTST(ph)AIASPEK ddPTM_A459_Selumetinib_30min_R2 1 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 HIKEEPLS(1)EEEPCT(0.265)S(0.225)T(0.497)AIAS(0.013)PEK 78.025 0.0024682 11053000.0 82782.0 83602.0 84722.0 73317.0 76405.0 58729.0 69632.0 65040.0 45528.0 71273.0 True False 78181.30784260225 90014.00457720089 79271.07875833892 63331.098121120434 66806.32083063362 66818.38666121825 72870.0259731904 65229.255632048385 54634.87215860653 69215.16330050681 1.1295401775354879 1.3004954447104768 1.1452848621359601 0.9149887842662463 0.9651977636834448 0.9653720871988318 1.0528043639341789 0.942412796872947 0.7893483097251679 1.0 16.07880051021531 -5.646119214189725 4.378758851904575 0.9509358436752101 1.216691107960153 0.6953892739405285 0.07488194437003802 0.11511197578929329 3.8231935862502366 0.020805038228965865 0.037209095493295395 2.258815638375291e-06 5.646119214189725 0.2657552642849429 HIKEEPLS(ph)EEEPCTSTAIAS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 HIKEEPLS(0.998)EEEPCT(0.208)S(0.148)T(0.133)AIAS(0.512)PEK 55.977 0.014063 86613000.0 4576.0 6102.4 6024.8 7556.8 4715.3 4812.8 4530.7 4783.6 2513.1 4330.3 True False 4682.6118966539925 5387.928171071206 5206.665251857506 6237.146738704425 4288.80194755383 4764.387601672769 4188.9456513125015 4656.723388677334 4264.547150438202 4886.136185693918 0.9583465787065405 1.1026970936353515 1.065599699636302 1.2764987510921453 0.8777491630525939 0.9750828508673958 0.8573125046283573 0.9530482188179117 0.8727851595549747 1.0 12.25447835941895 -6.296213240152928 24.99190596768878 0.9196688441840836 1.0984088858037422 0.5175533024724768 0.08420805090278417 479.46408931959706 344588.69153516204 0.02540296721690932 0.02880544925479042 5.055763612377107e-07 6.296213240152928 0.17874004161965862 HIKEEPLS(ph)EEEPCTSTAIAS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 5 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 HIKEEPLS(0.998)EEEPCT(0.061)S(0.057)T(0.053)AIAS(0.831)PEK;HIKEEPLS(0.999)EEEPCT(0.002)S(0.003)T(0.007)AIAS(0.99)PEK;HIKEEPLS(1)EEEPCT(0.065)S(0.065)T(0.065)AIAS(0.805)PEK;HIKEEPLS(0.995)EEEPCT(0.01)S(0.01)T(0.02)AIAS(0.965)PEK;HIKEEPLS(0.956)EEEPCT(0.015)S(0.017)T(0.025)AIAS(0.987)PEK 86.727 0.0004894999999999999 439008100.0 412243.0 407356.0 392128.0 380697.0 342029.0 281431.0 337798.0 336930.0 211204.0 367705.0 True False 389332.1843994817 438598.89534401393 366898.9113966858 328845.4118610443 299060.25924194424 320195.5656737445 353506.27633403876 337910.41051823547 253450.701532822 357088.4012376747 1.090296360929253 1.2282641884301546 1.027473617527222 0.9209075700058034 0.8374964244299061 0.896684307202197 0.9899685207046204 0.9462934369949627 0.7097701875904044 1.0 18.44592174824136 -5.568030485580949 2.9105600055318086 0.8982238083343353 1.1583982922832505 0.6027776839923954 0.08435033530055898 0.16654175170693525 2.8488617971378094 0.023478545547784897 0.048605309712252555 2.7037685646710895e-06 5.568030485580949 0.2601744839489152 HIKEEPLS(ph)EEEPCTSTAIAS(ph)PEKK ddPTM_A459_Selumetinib_30min_R1 2 HIKEEPLSEEEPCTSTAIASPEKK 24 2 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 2 HIKEEPLS(1)EEEPCT(0.011)S(0.037)T(0.007)AIAS(0.945)PEKK;HIKEEPLS(1)EEEPCT(0.043)S(0.138)T(0.119)AIAS(0.7)PEKK 102.51 3.2531e-05 17199700.0 3171.1000000000004 4152.8 5215.299999999999 5533.5 3410.9 4317.0 3205.0 3279.2 2211.16 3086.8 True False 3244.980460113523 3666.588245415656 4507.090905592294 4567.1781016595605 3102.3846972433057 4273.574899522385 2963.244269639696 3192.224963657224 3752.1770232632734 3483.0208479781945 0.9316569155757859 1.0527035023473998 1.2940177800567993 1.3112692404097126 0.8907166602359448 1.226973677749614 0.850768456169243 0.916510438204879 1.0772766477815707 1.0 11.766123393011569 -7.261889096286591 24.99991374541113 0.9541814242898419 1.1213963857870821 0.22665317397334117 0.14152542784729563 63.76163409621507 3544346.5463513564 0.05878946703048721 0.04238920317512271 5.47155669592475e-08 7.261889096286591 0.16721496149724024 HIKEEPLS(ph)EEEPCTSTAIASPEK ddPTM_A459_Selumetinib_30min_R1 5 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 HIKEEPLS(0.884)EEEPCT(0.087)S(0.023)T(0.006)AIASPEK;HIKEEPLS(0.999)EEEPCT(0.001)STAIASPEK;HIKEEPLS(0.992)EEEPCT(0.006)S(0.002)T(0.001)AIASPEK;HIKEEPLS(0.93)EEEPCT(0.042)S(0.011)T(0.017)AIASPEK;HIKEEPLS(0.968)EEEPCT(0.01)S(0.01)T(0.011)AIAS(0.002)PEK 129.8 4.4808e-06 507410000.0 18447.600000000002 25427.7 26096.999999999996 28552.6 24072.100000000002 22418.699999999997 23244.4 20946.9 10851.460000000001 17765.8 True False 18877.393187219022 22450.613062982986 22553.170740559894 23566.424408682517 21894.782805274433 22193.188232550947 21491.05619382619 20391.320166879603 18414.135060719484 20046.21348354641 0.9416937120176468 1.119942830171397 1.1250588924971368 1.1756047808243406 1.0922153863743544 1.1071012613313103 1.072075592304037 1.01721555462913 0.9185842042355526 1.0 14.291042132219237 -7.855100211844339 2.4309662495587125 0.9598736801556016 1.0990879457729776 0.44091399003420495 0.059782438249463304 0.2657886931297179 3.0734346530516183 0.04250270167424304 0.016928249974622764 1.3960461913958587e-08 7.855100211844339 0.13921426561737604 HIKEEPLS(ph)EEEPCTSTAIASPEK ddPTM_A459_Selumetinib_30min_R2 5 HIKEEPLSEEEPCTSTAIASPEK 23 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 HIKEEPLS(0.996)EEEPCT(0.003)S(0.001)TAIASPEK;HIKEEPLS(0.997)EEEPCT(0.001)S(0.001)T(0.001)AIASPEK;HIKEEPLS(0.932)EEEPCT(0.021)S(0.021)T(0.024)AIAS(0.001)PEK;HIKEEPLS(0.885)EEEPCT(0.049)S(0.049)T(0.016)AIASPEK;HIKEEPLS(0.954)EEEPCT(0.02)S(0.012)T(0.014)AIASPEK 100.39 2.6215e-05 233313200.0 463321.0 382577.0 431998.0 442262.0 414955.0 334344.0 365510.0 388071.0 284999.0 377759.0 True False 437571.47364091646 411919.4257210564 404203.7190038588 382025.1526554952 362824.64315523254 380396.8511273545 382506.93924432463 389200.2223613874 342006.76353739906 366852.1161342467 1.1927734757315414 1.1228487109784524 1.101816511959123 1.0413600899488775 0.9890215353765593 1.0369215125043771 1.0426733891439492 1.0609185697567642 0.9322742012267535 1.0 18.484839081601727 -5.077211646661601 0.8326754176411904 1.0122982260437228 1.2454600704235095 0.7522165954982831 0.034783998596581385 0.870575208616274 0.6260305188853603 0.013669498081542665 0.1721625538982595 8.371212246948044e-06 5.077211646661601 0.2331618443797867 HIKEEPLS(ph)EEEPCTSTAIASPEKK ddPTM_A459_Selumetinib_30min_R1 1 HIKEEPLSEEEPCTSTAIASPEKK 24 2 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 HIKEEPLS(0.861)EEEPCT(0.09)S(0.035)T(0.014)AIASPEKK 63.398 0.0045902 20349000.0 1799.9 2006.5 3627.4 3473.1 2851.3 2511.8 2551.7 2555.2 1179.2 1860.6 True False 1841.8341680042672 1771.5780472034562 3134.81900388194 2866.5882831614354 2593.400418437902 2486.533572531925 2359.223214614543 2487.4277955406646 2001.0162746395797 2099.4261337787448 0.8773036299634704 0.8438391895288087 1.4931789946996599 1.3654151660967848 1.2352901474890454 1.184387263035746 1.1237467118541538 1.1848131999117102 0.9531253528972521 1.0 11.035779313937285 -8.2594591945592 24.54894189186293 0.9765626586994095 1.1723260170814704 0.1388488261290568 0.18517459679602288 275.1677153507231 3411488.0024958365 0.15321853173533123 0.05129666777883838 5.502256161803451e-09 8.2594591945592 0.19576335838206094 HIKEEPLS(ph)EEEPCTSTAIASPEKK ddPTM_A459_Selumetinib_30min_R2 2 HIKEEPLSEEEPCTSTAIASPEKK 24 2 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 HIKEEPLS(0.962)EEEPCT(0.027)S(0.01)T(0.001)AIASPEKK;HIKEEPLS(0.934)EEEPCT(0.06)S(0.005)T(0.002)AIASPEKK 72.167 0.00039093 23817000.0 73192.0 66458.0 65645.0 68767.0 65632.0 44208.0 56668.0 50796.0 34967.0 66318.0 True False 69124.28165079062 71555.11490384958 61421.47216887186 59400.81597030837 57386.72140247544 50297.25071973203 59303.174285511755 50943.80795026952 41961.37705961153 64403.22702514279 1.07330462841256 1.1110485950636404 0.9537017787151121 0.9223267018455226 0.8910535085465806 0.780974076036534 0.9208106025861097 0.7910132815298406 0.651541529793685 1.0 15.97484535820813 -5.6210141904638204 0.8709108045249575 0.8181042455124671 1.1329251632681054 0.5453943878371903 0.08927849661246268 0.6417958975597706 0.8124973769962034 0.03677480714631032 0.15336549343302028 2.3932375566878705e-06 5.6210141904638204 0.31482091775563836 HIMGQNVADYMR ddPTM_A459_Selumetinib_30min_R2 1 HIMGQNVADYMR 12 0 A0A2R8Y6J3;P46777 A0A2R8Y6J3 RPL5 60S ribosomal protein L5 0 98.105 0.021904 3852100.0 31981.0 25204.0 35219.0 36331.0 40519.0 35559.0 33742.0 26416.0 25326.0 33539.0 False True 30203.624050086535 27137.06575636675 32953.04788354784 31382.655125529247 35428.640975544 40456.92947753687 35311.06985850457 26492.866186595784 30391.907667564337 32570.64192521284 0.9273266434060053 0.8331756499818944 1.0117408173659292 0.9635258401596324 1.0877477041101482 1.2421287112004777 1.0841379773718973 0.8133971153355665 0.9331074203986766 1.0 14.991284533216179 -3.1853074965531314 19.581748579172054 0.9923532626547996 0.5633605737527259 0.0 0.12094586567760125 0.0 0.0 0.030854076333502328 0.0 0.0006526682757377159 3.1853074965531314 -0.42899268890207376 HIQSNLDFS(ph)PVNSASSEENVK ddPTM_A459_Selumetinib_30min_R1 1 HIQSNLDFSPVNSASSEENVK 21 0 E7EPP6;O14757-2;O14757-3;O14757 E7EPP6 CHEK1 Serine/threonine-protein kinase Chk1 1 HIQS(0.062)NLDFS(0.873)PVNS(0.058)AS(0.003)S(0.003)EENVK 61.276 0.011885 8984800.0 2299.1 1852.4 2471.7 3686.4 2609.4 2293.4 2286.3 2024.1 1016.5 1469.6 True False 2352.6645567301566 1635.5201468426042 2136.056716076252 3042.639442298328 2373.380230726987 2270.3304782405917 2113.8425502893087 1970.4142927965938 1724.926257777419 1658.2374751162222 1.418774205766435 0.9863003166829131 1.2881488617464398 1.8348635150011166 1.431266791603924 1.3691226451636362 1.274752610533756 1.1882582093125666 1.0402166659853849 1.0 10.695434913714855 -7.912714094761263 1.4270751424768064 1.0051179899925309 1.3866719700160128 0.360766756443492 0.1939594578833618 0.5411369848788224 1.9909678716399504 0.18601451797855054 0.06544666391105404 1.2226042615248722e-08 7.912714094761263 0.38155398002348195 HISESCPFPS(ph)PGGQLAEVHSVSPEQGAK ddPTM_A459_Selumetinib_30min_R1 1 HISESCPFPSPGGQLAEVHSVSPEQGAK 28 0 Q5T1V6;Q5T1V6-2;Q5T1V5 Q5T1V6 DDX59 Probable ATP-dependent RNA helicase DDX59 1 HIS(0.008)ES(0.022)CPFPS(0.958)PGGQLAEVHS(0.011)VS(0.002)PEQGAK 41.562 0.041932 5108800.0 1130.9 1291.9 1708.2 1698.6 1507.9 1680.2 1369.1 1183.9 899.44 1391.0 True False 1157.2477696516614 1140.643747411985 1476.2358224709515 1401.971396670991 1371.5107112413677 1663.2987134995385 1265.827684731267 1152.499126150826 1526.2839875015475 1569.5483994873885 0.7373125734954185 0.7267337202118247 0.9405481366188435 0.8932323444940419 0.873825051644983 1.0597307569761905 0.806491653997216 0.7342870895394051 0.9724351208284044 1.0 10.616133802033108 -5.253990345581013 24.555270387095728 0.9003291919734382 0.7320231151629532 0.3863828143685163 0.0890753702635796 486.9640477842252 1605232.6758435601 0.023270824490324946 0.05894687041468057 5.571981353763584e-06 5.253990345581013 -0.16830607681048504 HIVSNDS(ph)SDSDDESHEPK ddPTM_A459_Selumetinib_30min_R1 2 HIVSNDSSDSDDESHEPK 18 0 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 HIVS(0.222)NDS(0.491)S(0.282)DS(0.005)DDESHEPK;HIVS(0.196)NDS(0.521)S(0.081)DS(0.202)DDESHEPK 125.45 0.0005459 34148000.0 9880.8 12355.699999999999 9765.7 9590.3 11337.7 10461.400000000001 13447.2 13232.3 5032.1 12140.0 True False 10111.003415310046 10909.08889999091 8439.571579150315 7915.53413722701 10312.207036833515 10356.16781419121 12432.86687759717 12881.336419432026 8539.106169957453 13698.287253613877 0.7381217248632719 0.7963834235636195 0.6161041466643059 0.5778484558453639 0.752809956888074 0.7560191739634494 0.9076220002845345 0.9403610963139699 0.623370353669921 1.0 13.741707898633914 -6.931155946793707 2.3771996517311655 0.8611124643362239 0.6879951984062834 0.3503785657153119 0.10967547797888318 0.35485770548441625 4.067773708375873 0.045188357232442085 0.03749876904023994 1.1717745283042835e-07 6.931155946793707 -0.17311726592994048 HIVSNDS(ph)SDSDDESHEPK ddPTM_A459_Selumetinib_30min_R2 2 HIVSNDSSDSDDESHEPK 18 0 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 HIVS(0.038)NDS(0.611)S(0.348)DS(0.003)DDESHEPK;HIVS(0.142)NDS(0.438)S(0.191)DS(0.229)DDESHEPK 142.93 0.0001967 35829000.0 347380.0 246920.0 352550.0 263373.0 286780.0 203892.0 275210.0 311360.0 158745.0 225608.0 True False 328074.01027231955 265857.97002706234 329867.316827417 227501.14305623344 250752.13255427143 231976.27225270533 288007.81031826953 312266.0060515768 190498.43570589513 219094.11084001942 1.497411359047785 1.2134418812433962 1.5055964560739983 1.0383717854577696 1.144495082925202 1.0587973878590116 1.3145392599282155 1.4252596970969735 0.8694822283242264 1.0 17.741191180234203 -1.5228787452803376 0.3721079781254699 1.1251810665612783 5.668283700508733 0.28702725688487263 0.17788423304330653 100.55472180903904 1.385915569371651 0.14073673972277792 327.14082246097206 0.029999999999999995 1.5228787452803376 4.543102633947456 HIVSNDSS(ph)DSDDESHEPK ddPTM_A459_Selumetinib_30min_R2 1 HIVSNDSSDSDDESHEPK 18 0 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 HIVS(0.162)NDS(0.262)S(0.564)DS(0.012)DDESHEPK 113.7 0.00075863 21926000.0 209670.0 157160.0 205800.0 159300.0 184520.0 114870.0 165280.0 184330.0 97288.0 128820.0 True False 198017.38077551173 169213.6666509521 192559.05205809826 137603.0651921726 161338.94797027035 130692.2998139616 172965.84749610702 184866.36978252567 116748.31845384205 125100.63188544422 1.5828647528882032 1.3526203992790586 1.5392332489129736 1.0999390100457442 1.2896733256951882 1.0446973595915783 1.3826136997812561 1.477741295118393 0.9332352418551294 1.0 16.932729551036424 -1.5228787452803376 0.20367581844468177 1.08171084813274 3.259372933470376 0.38405341849276187 0.1753888438544409 64.61632144342401 0.7896096852149896 0.31804017569000315 45.15156968738635 0.029999999999999995 1.5228787452803376 2.1776620853376363 HIYYITGETK ddPTM_A459_Selumetinib_30min_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 101.38 0.023068 30070000.0 5447.9 6866.5 7720.4 7696.0 6885.0 6117.7 6253.4 6393.3 4058.0 4822.1 False True 5574.825470231924 6062.5669878507515 6672.012085121609 6352.038071812046 6262.25296564548 6056.161492427169 5781.7010033587785 6223.728915634832 6886.129615406564 5441.063506231589 1.0245837902548167 1.1142246329062988 1.2262330843005653 1.16742582852362 1.1509244393992815 1.1130473822794231 1.0626049478630533 1.1438441967286113 1.2655852311813596 1.0 12.409672951801019 -11.028514772585458 2.943300914554398 0.9950821239333852 1.1406977973607784 0.28528316167316925 0.06692410596317092 41910450.489679866 47451983.27314789 1667671.2131894033 0.01786884339984423 9.364513658328769e-12 11.028514772585458 0.14561567342739312 HIYYITGETK ddPTM_A459_Selumetinib_30min_R2 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 121.5 0.0066831 23992000.0 164810.0 174650.0 177290.0 193470.0 187050.0 134650.0 160480.0 166010.0 100420.0 179520.0 False True 155650.51998670335 188045.0934117381 165883.3544187568 167119.0522456348 163551.10675178326 153196.8152689991 167942.6379850873 166493.06161556518 120506.80596923381 174336.79115102417 0.8928151020737022 1.0786311493414993 0.9515108849001107 0.9585988771633591 0.9381330565508831 0.8787405931791417 0.9633229846452906 0.955008179950587 0.6912299186741448 1.0 17.411517535065286 -6.536241194581888 0.8110722597205257 0.8865232716181244 0.9873383671678101 0.12605435915681062 0.08922257374680997 1.2511909222734403 1.8241720499252956 0.05288178681160687 0.06473320057669141 2.909101038851426e-07 6.536241194581888 0.10081509554968571 HKAEEVEDETVELDVS(ph)DEEMAR ddPTM_A459_Selumetinib_30min_R1 3 HKAEEVEDETVELDVSDEEMAR 22 1 H3BSB3;H3BNT4;Q99547 H3BSB3 MPHOSPH6 M-phase phosphoprotein 6 1 HKAEEVEDETVELDVS(1)DEEMAR;HKAEEVEDETVELDVS(1)DEEMAR;HKAEEVEDETVELDVS(1)DEEMAR 134.53 1.0286e-05 25955900.0 6238.51 8755.0 8760.0 5534.54 8686.650000000001 4678.58 5732.36 5063.71 3672.42 4274.9400000000005 True False 6383.85514497266 7729.960529910919 7570.4401152356495 4568.036485182777 7900.944041252622 4631.517733010756 5299.963470050486 4929.403961551819 6231.82851705554 4823.67019044185 1.3234435384123757 1.6025060223287886 1.569435682032439 0.947004315144594 1.6379527889175385 0.9601646775495046 1.0987408468664412 1.0219197762151073 1.2919267427122132 1.0 12.235915553657945 -6.222771916799352 0.8377744994180661 1.0842761719198233 1.5015860173819267 0.31344747008047513 0.21874472109994744 0.7801323456446504 1.1681853349147022 0.11140888162279637 0.1961902637036142 5.987259519868389e-07 6.222771916799352 0.41730984546210337 HKDTYSTEAPLGEGTEQYVNSIS(ph)D ddPTM_A459_Selumetinib_30min_R2 2 HKDTYSTEAPLGEGTEQYVNSISD 24 1 Q9GZR1-2;Q9GZR1 Q9GZR1-2 SENP6 Sentrin-specific protease 6 1 HKDTYSTEAPLGEGTEQYVNS(0.013)IS(0.987)D;HKDTYSTEAPLGEGTEQYVNS(0.012)IS(0.988)D 122.22 8.2075e-08 9359600.0 65082.0 71057.0 64014.0 81398.0 78674.0 59048.0 56342.0 69156.0 47495.0 74735.0 True False 61465.00298388831 76506.84341573386 59895.40893317333 70311.45198061805 68790.26876551616 67181.3260156247 58962.01463955503 69357.23251060786 56995.32712117851 72577.20636515034 0.846891277058057 1.0541442313281217 0.825264734382688 0.9687814604886714 0.947821943151389 0.9256532371557828 0.8124040258990601 0.9556338137576948 0.785306158443516 1.0 16.147228905356627 -7.032229117733523 24.796799746515532 0.8824087857301378 0.9325188472091732 0.049565081277153866 0.08288341598087273 1600.264513181618 1231224.6499010713 0.02912666283285313 0.022582915671341394 9.284764276673315e-08 7.032229117733523 0.050110061479035406 HKELAPYDENWFYTR ddPTM_A459_Selumetinib_30min_R1 1 HKELAPYDENWFYTR 15 1 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 105.46 0.0037638000000000007 15750000.0 3577.5 3152.8 6066.7 6638.3 4125.6 4122.7 2570.0 2492.2 1941.0 1907.4 False True 3660.8487893967804 2783.6687103030454 5242.875461997732 5479.045521324051 3752.4402084338376 4081.229381112101 2376.1428308811296 2426.098760193503 3293.735234968984 2152.23336964935 1.7009534565451048 1.2933860935148362 2.4360162498790365 2.545748801495777 1.7435099099152054 1.8962764162406003 1.104035865436033 1.1272470701394115 1.5303801536659623 1.0 11.07161880446264 -7.234928193908913 7.285774306299261 1.200703070834297 1.9500301057113967 0.5074725232268154 0.3596362460544411 0.19345415456672668 42.362492833060735 0.15261127970204197 0.11549997018482988 5.8219947046135834e-08 7.234928193908913 0.7493270348770997 HKMS(ph)PPPSGFGER ddPTM_A459_Selumetinib_30min_R1 1 HKMSPPPSGFGER 13 1 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 HKMS(1)PPPSGFGER 114.27 0.020331 18021000.0 1084.6 1584.7 1467.4 1830.8 1339.1 1134.9 1346.3 1583.6 887.46 1075.2 True False 1109.8690697357783 1399.1625872929571 1268.135139851232 1511.0851483723363 1217.9786414373068 1123.4839364067534 1244.747507087651 1541.5977837422486 1505.9548024861272 1213.2123933348958 0.9148184405575962 1.1532709317672882 1.0452705122516626 1.245523996188865 1.0039286180462677 0.9260406030954765 1.0259930692482222 1.2706742794678203 1.2412952676377933 1.0 10.244616425382267 -7.747457878317556 24.997357191706907 1.1919885902647551 1.050714336680898 0.19446281053172332 0.11436424508550354 329.49827055532324 589108.2199490217 0.05454747641697944 0.031291248167241735 1.7887190063299554e-08 7.747457878317556 -0.14127425358385715 HKMS(ph)PPPSGFGER ddPTM_A459_Selumetinib_30min_R2 1 HKMSPPPSGFGER 13 1 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 HKMS(0.995)PPPS(0.005)GFGER 64.827 0.04648 6425700.0 13542.0 13197.0 15779.0 14864.0 15736.0 10686.0 12036.0 15735.0 9805.3 14164.0 True False 12789.389852921164 14209.167464956836 14763.796318876219 12839.497558169802 13759.102998375101 12157.899502150196 12595.697848881551 15780.786244930518 11766.633982972766 13755.048517508409 0.9297960553641025 1.0330147106984313 1.073336549855408 0.9334389145793831 1.000294763109089 0.8838863408351306 0.9157145344015942 1.1472723069528694 0.8554411108034518 1.0 13.74767360796005 HKS(ph)DNETNLQQQVVWGNR ddPTM_A459_Selumetinib_30min_R2 1 HKSDNETNLQQQVVWGNR 18 1 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 HKS(0.996)DNET(0.004)NLQQQVVWGNR 74.33800000000002 0.0089935 5729700.0 10809.0 8404.7 13454.0 10400.0 12326.0 9947.6 8918.6 12703.0 10202.0 13673.0 True False 10208.279051855334 9049.313464630046 12588.384287607629 8983.502058999316 10777.497684161894 11317.791604678028 9333.33257187063 12739.963626905146 12242.685067696877 13278.224963279617 0.7687984711876706 0.6815152996470197 0.9480472218553523 0.6765589590357762 0.8116670499232103 0.8523572718474731 0.7029051396313569 0.9594628545710733 0.9220121741839378 1.0 13.696774679258915 -7.777177132749712 24.82764375246734 0.9555532610165555 0.7806036215167392 0.5229291664945928 0.08005429685762605 184.95133319640757 291771.9447915521 0.04167225147643926 0.020128330543365696 1.6704091768729414e-08 7.777177132749712 -0.17494963949981623 HKS(ph)TSSTLCPAVCPAAGHTLTPDR ddPTM_A459_Selumetinib_30min_R1 1 HKSTSSTLCPAVCPAAGHTLTPDR 24 1 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 HKS(0.239)T(0.239)S(0.239)S(0.239)T(0.046)LCPAVCPAAGHTLTPDR 112.57 1.1059e-07 23824000.0 2339.3 2371.6 2440.5 2208.8 2436.3 2452.4 2602.3 2375.0 1145.4 2027.7 True False 2393.8011385145737 2093.931969473072 2109.093504706918 1823.0745443111286 2215.937095163701 2427.7310826010407 2406.0064158762493 2312.007284912756 1943.660143293908 2287.975046470581 1.046253167055838 0.9151900378909993 0.9218166552823183 0.7968070050079411 0.9685145380330937 1.0610828498090688 1.051587699607014 1.0105037152740135 0.8495110758712987 1.0 11.159855602281247 -6.51398901705589 24.933615008114817 1.0005413845092366 0.91515805199278 0.16698488319862648 0.07772897021186162 694.7159907664338 1948521.9658167 0.025828313977358405 0.027141717807104764 3.062040869163368e-07 6.51398901705589 -0.08538333251645658 HKS(ph)TSSTLCPAVCPAAGHTLTPDR ddPTM_A459_Selumetinib_30min_R2 2 HKSTSSTLCPAVCPAAGHTLTPDR 24 1 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 HKS(0.2)T(0.2)S(0.2)S(0.2)T(0.2)LCPAVCPAAGHTLTPDR;HKS(0.2)T(0.2)S(0.2)S(0.2)T(0.2)LCPAVCPAAGHTLTPDR 98.684 3.2475e-06 26596400.0 41625.0 43466.4 57932.0 76120.0 93446.0 52875.9 62073.4 66707.0 51194.0 45915.8 True False 39311.64913807733 46800.133113495474 54204.71819159247 65752.32468567585 81706.47806216063 60159.07526536998 64959.936096108686 66901.10632606174 61434.23047987394 44590.09155042449 0.8816229743242833 1.0495635125703155 1.2156224916088212 1.4745949694075005 1.8323909016818962 1.3491579221661696 1.456824461161939 1.5003581288997119 1.3777551995021435 1.0 15.444435541282626 -5.398636862486965 2.083543022486563 1.4612765889161523 0.9287348701145478 0.46673899426362786 0.19595937492341542 0.2737412704724815 2.2473955147822204 0.05467599678462755 0.16539612728218234 3.993586885681007e-06 5.398636862486965 -0.5325417188016045 HKSES(ph)PCESPYPNEK ddPTM_A459_Selumetinib_30min_R2 2 HKSESPCESPYPNEK 15 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;B7ZBA0;B7ZB98 A0A0C4DG98 THOC2 THO complex subunit 2 1 HKS(0.012)ES(0.834)PCES(0.15)PY(0.004)PNEK;HKS(0.014)ES(0.958)PCES(0.027)PY(0.001)PNEK 124.77 0.00070776 9698800.0 38729.0 29282.0 50268.0 66807.0 81751.0 56572.0 45805.0 58900.0 57114.0 65831.0 True False 36576.597224470825 31527.835243530055 47033.81160766019 57707.77135149693 71480.70851678726 64364.27949051482 47935.023260885624 59071.38924858009 68538.39589849435 63930.287980520676 0.5721325271617043 0.4931595999244751 0.7357046729085784 0.9026671578435604 1.1181039656597067 1.006788511732129 0.7498014599197684 0.9239969209364257 1.072080199597689 1.0 15.964211972173223 -5.5833944724015625 2.393852174753572 0.9667505256754495 0.5327477582259922 0.7719261706903863 0.09594607840178099 0.14472900360338126 1.6603063832317095 0.029937262153520397 0.06578050303183887 2.6097897890758816e-06 5.5833944724015625 -0.4340027674494573 HKSESPCES(ph)PYPNEK ddPTM_A459_Selumetinib_30min_R2 1 HKSESPCESPYPNEK 15 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;B7ZBA0;B7ZB98 A0A0C4DG98 THOC2 THO complex subunit 2 1 HKS(0.14)ES(0.235)PCES(0.574)PY(0.051)PNEK 67.095 0.026241000000000004 7762500.0 25021.0 15547.0 33502.0 43664.0 57593.0 37461.0 31151.0 39039.0 36020.0 41904.0 True False 23630.432986999014 16739.40490851587 31346.517794219613 37716.8878753987 50357.652452047354 42620.91271289993 32599.58322453546 39152.59702674563 43225.006482889796 40694.12264033272 0.5806841738757244 0.41134699122190016 0.7702959484166759 0.9268387036809286 1.2374674568395028 1.0473481168176737 0.8010882434463742 0.9621192075521183 1.0621928592717385 1.0 15.31253282391973 -5.5543540298256 2.527632922162805 1.0092606984174406 0.4967675253905428 0.7693375232232809 0.11158555924131504 0.13653871584238872 1.7430768566133539 0.034124498751341464 0.07559234383040914 2.7902683323452423e-06 5.5543540298256 -0.5124931730268978 HKSTSST(ph)LCPAVCPAAGHTLTPDR ddPTM_A459_Selumetinib_30min_R2 1 HKSTSSTLCPAVCPAAGHTLTPDR 24 1 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 HKS(0.185)T(0.185)S(0.185)S(0.185)T(0.259)LCPAVCPAAGHTLTPDR 76.028 0.00022774 30279000.0 73999.0 65383.0 76453.0 101130.0 106800.0 71855.0 83770.0 72207.0 65305.0 74158.0 True False 69886.43182146756 70397.66586051932 71534.09721573238 87355.91954101919 93382.82919588588 81752.37401525394 87665.47098710583 72417.11041548761 78367.82477415657 72016.86585437658 0.97041756805667 0.9775163779394205 0.9932964503117868 1.2129925192476345 1.296679994165712 1.1351837246092225 1.217290838015249 1.005557650369295 1.0881871051237095 1.0 16.136047194924124 -5.695230845938673 7.651009678239528 1.1466099635612896 0.9783930688642882 0.3960618806561498 0.0877939797524828 0.24414179497402788 24.140981686176378 0.02518509610566757 0.04364992010900287 2.0172938014273e-06 5.695230845938673 -0.1682168946970014 HKYVSGSS(ph)PDLVTR ddPTM_A459_Selumetinib_30min_R1 1 HKYVSGSSPDLVTR 14 1 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 HKYVS(0.006)GS(0.126)S(0.867)PDLVT(0.001)R 123.63 0.007597800000000002 5235800.0 1679.5 1567.8 2410.7 2592.0 2071.9 1709.1 1547.7 1404.4 887.94 1030.2 True False 1718.6290822618832 1384.2412471495545 2083.340181027236 2139.355857866011 1884.4970108236553 1691.9080057386402 1430.955742939582 1367.150749865885 1506.7693274283154 1162.436204997776 1.4784717431139984 1.190810507448194 1.7922189381835556 1.8404071110896825 1.6211616626542191 1.4554846093613174 1.2309972252991894 1.1761081975836263 1.2962167910377482 1.0 10.182935827326796 -7.173523929743083 2.490051534397036 1.179557523526242 1.5870004772229767 0.5367552969803986 0.1798814327526733 0.27173692692605295 3.2934066722984086 0.0888934803721978 0.06304468431972024 6.706193343780543e-08 7.173523929743083 0.40744295369673456 HLAAVEER ddPTM_A459_Selumetinib_30min_R2 1 HLAAVEER 8 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 91.069 0.046137 0.0 2839.7 2733.8 3166.5 3527.6 3697.7 3237.5 2075.4 2905.4 1973.8 2617.4 False True 2681.880842219778 2943.473669447527 2962.770837424524 3047.134794550576 3233.16186814258 3683.4362379011113 2171.910212327082 2913.8542329851375 2368.615152579895 2541.828861178092 1.0550989026762307 1.1580141033111409 1.165605947227829 1.1987962057910868 1.271982515236713 1.4491283398969295 0.8544675235611419 1.1463612981538884 0.9318546927986664 1.0 11.311651183045365 -7.277689237700858 24.99545140471989 0.9953676674218088 1.2131944164336803 0.48797232491558007 0.11676438970653723 807.3581257353186 1241869.2129996435 0.049966304064869176 0.03379415491998986 5.276072592582961e-08 7.277689237700858 0.2178267490118715 HLAESESLLT(ph)SPPK ddPTM_A459_Selumetinib_30min_R2 1 HLAESESLLTSPPK 14 0 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 HLAESESLLT(0.774)S(0.226)PPK 205.31 2.0102e-29 0.0 27257.0 26726.0 24775.0 25589.0 29279.0 20969.0 29485.0 25559.0 24007.0 25423.0 True False 25742.165058416198 28775.798262365406 23181.003472980443 22103.734056512847 25600.710262418957 23857.289412370177 30856.110923419124 25633.372458479782 28809.07081162508 24688.97193311327 1.0426584439463988 1.1655324628471393 0.9389213749273086 0.8952877469501653 1.0369289710311043 0.9663136025673218 1.2497932683067448 1.0382519178167913 1.1668801313264026 1.0 14.591579142401985 -7.219323302846109 24.999763016418342 1.1169192406635169 1.0078908281988086 0.2386955172930333 0.09277827105481623 721.4367177447043 428239.28676305484 0.0359013084098439 0.027808848011900613 6.03499197807139e-08 7.219323302846109 -0.10902841246470829 HLAESESLLTS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 4 HLAESESLLTSPPK 14 0 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 HLAESESLLT(0.247)S(0.753)PPK;HLAESESLLT(0.04)S(0.96)PPK;HLAESESLLT(0.215)S(0.785)PPK;HLAESESLLT(0.013)S(0.987)PPK 158.01 0.00030899 66887200.0 12403.7 20309.8 13508.699999999999 14857.4 13747.999999999998 15558.000000000002 15459.699999999999 14516.399999999998 6941.2 13600.1 True False 12692.682076601213 17931.919174230145 11674.292737977614 12262.833997939222 12504.49582740653 15401.500645533772 14293.562382324119 14131.377916087376 11778.709434810253 15345.80531119225 0.8271108501125047 1.1685225252500595 0.7607481328766194 0.7991000634548318 0.814847808494387 1.0036293523351882 0.9314312342995325 0.9208625829353414 0.7675523829446483 1.0 13.905556736528704 -6.3237900469174875 0.0025063250851291943 1.7965005246330816 1.2210248392067894e-07 0.007715228211915726 0.12359328802405914 1108383.5029824262 822.7283130239418 292105.85275845893 297610.66280431673 4.744713057838708e-07 6.3237900469174875 -1.7965004025305977 HLAESESLLTS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 4 HLAESESLLTSPPK 14 0 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 HLAESESLLT(0.247)S(0.753)PPK;HLAESESLLT(0.31)S(0.69)PPK;HLAESES(0.001)LLT(0.259)S(0.739)PPK;HLAESESLLT(0.088)S(0.912)PPK 103.6 0.0044786 85772000.0 160454.0 123953.0 151530.0 150962.0 149121.0 139486.0 164870.0 171754.0 118056.0 147893.0 True False 151536.60902825388 133459.7965282862 141780.72477338943 130400.71517602436 130387.0868213456 158698.93037216205 172536.78168370717 172253.77570459453 141670.49876024498 143622.94481783887 1.0551002781655268 0.9292372935087575 0.9871732191065573 0.9079379018541596 0.9078430120390534 1.1049691995484738 1.2013176717866394 1.1993471929089672 0.9864057511140004 1.0 17.13192672311446 -6.80076547723963 8.956094720789068 1.1176864526431594 0.9548430164229831 0.4390157197889093 0.07814114898662461 0.25219661330785875 53.30472769715718 0.02734687115660472 0.024256747209298338 1.5821021574241135e-07 6.80076547723963 -0.16284343622017627 HLDGEEDGS(ph)SDQSQASGTTGGR ddPTM_A459_Selumetinib_30min_R1 1 HLDGEEDGSSDQSQASGTTGGR 22 0 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 HLDGEEDGS(0.794)S(0.206)DQSQASGTTGGR 328.58 1.556399999999999e-161 7413000.0 654.71 631.83 655.37 724.82 837.79 580.7 645.81 884.03 251.79 451.7 True False 669.963469156105 557.8550498702024 566.3743536897246 598.2437935564977 762.0120424238377 574.8586852334142 597.0960317553861 860.582652665863 427.26923998600705 509.680094930592 1.3144783871682104 1.0945199850234897 1.111234987049775 1.1737633066442712 1.4950790701912895 1.1278813729457067 1.171511380754821 1.6884760876978266 0.8383086650542874 1.0 8.993448201041023 -4.376113190223115 18.037794846740837 1.2140958872026197 45.88822617076755 0.015872634958778775 0.22951973126451866 636.6086496549821 78237.33674786918 0.052675383667921814 56.13415554669199 4.206169886409562e-05 4.376113190223115 44.674130283564935 HLDGEEDGS(ph)SDQSQASGTTGGR ddPTM_A459_Selumetinib_30min_R2 3 HLDGEEDGSSDQSQASGTTGGR 22 0 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 HLDGEEDGS(0.787)S(0.213)DQSQASGTTGGR;HLDGEEDGS(0.5)S(0.5)DQSQASGTTGGR;HLDGEEDGS(0.764)S(0.236)DQSQASGTTGGR 181.49 2.1948e-16 32593500.0 30875.3 32299.6 43670.3 38010.4 43809.8 28528.7 38910.2 34033.1 20483.4 27517.6 True False 29159.374429618732 34776.87546041675 40860.60044262754 32833.31794840268 38306.02125941876 32458.26946724615 40719.601399098574 34132.13068651698 24580.652354015132 26723.095388688896 1.091167546479703 1.3013790114724801 1.529036956546682 1.2286495060111957 1.4334425223670975 1.2146148863048547 1.5237606574698674 1.2772521367776921 0.9198280362543406 1.0 14.705799507244109 -8.202290147785298 5.008306864733552 0.9591565377359274 1.337011595546586 0.5512010642143592 0.1320028168522362 0.13852396155884417 7.1543968913123415 0.09467760931014187 0.03284751958298507 6.276388994601334e-09 8.202290147785298 0.37785505781065865 HLDMGS(ph)PQLR ddPTM_A459_Selumetinib_30min_R2 1 HLDMGSPQLR 10 0 Q5HYA6;Q76N32-2;Q76N32 Q5HYA6 DKFZp686H16130;CEP68 Centrosomal protein of 68 kDa 1 HLDMGS(1)PQLR 88.163 0.021587 3933700.0 27673.0 22606.0 29889.0 34999.0 32209.0 28579.0 25634.0 27698.0 21608.0 27925.0 True False 26135.04544379616 24339.807510253413 27965.97428068263 30232.075823357427 28162.6174678866 32515.49783566824 26826.03179280736 27778.59659434924 25930.203777964532 27118.732692136567 0.9637266512595686 0.8975274688006 1.0312419314783 1.1148041527812107 1.0384931253093814 1.1990050643146954 0.9892066896100171 1.0243324018752547 0.9561731395170739 1.0 14.727002139827173 -5.358646846029315 5.43038310241855 1.0520582501604023 0.9314456105229986 0.3135397089821039 0.066841823694063 0.2385565647609362 10.498442618848047 0.017990811611068153 0.03857290545418505 4.378780284188016e-06 5.358646846029315 -0.12061263963740376 HLDRS(ph)PESDRPR ddPTM_A459_Selumetinib_30min_R2 2 HLDRSPESDRPR 12 2 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 HLDRS(0.995)PES(0.005)DRPR;HLDRS(0.914)PES(0.086)DRPR 86.214 0.034131 22788000.0 24020.0 26487.0 31373.0 30976.0 27601.0 24985.0 20247.5 27870.0 19328.7 31836.0 True False 22685.064559678514 28518.46773087154 29354.495336339674 26757.01536341952 24133.515623929266 28426.456958751914 21189.048869660113 27951.097085873116 23194.98008900143 30916.811960138217 0.7337452706613771 0.9224258881427063 0.949467085228164 0.8654519553283171 0.780595219683232 0.9194498124645848 0.68535685040811 0.9040743632270731 0.7502384178196404 1.0 14.916103940518985 -6.016194609060431 24.29127475855609 0.8306396416933995 0.8795216317347285 0.009731370204766998 0.10001130699843794 1686.7215807617886 2530021.415877908 0.027665443745222066 0.03677409324398827 9.633972248114155e-07 6.016194609060431 0.04888199004132898 HLDS(ph)PPAIPPR ddPTM_A459_Selumetinib_30min_R2 2 HLDSPPAIPPR 11 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 HLDS(1)PPAIPPR;HLDS(1)PPAIPPR 118.76 0.002568 0.0 20019.1 14897.4 17662.0 20066.9 16100.6 15960.2 15712.1 18523.6 15225.5 18795.800000000003 True False 18906.518564806833 16039.982677309077 16525.64614893161 17333.753602666686 14077.898686809745 18158.572677729517 16442.743782935508 18577.500609252947 18271.02543601439 18253.11641664676 1.0357967446898093 0.8787531022746715 0.9053602558443278 0.9496325562717817 0.7712600065362408 0.9948204056359921 0.9008184360200431 1.0177714416103953 1.0009811485862927 1.0 14.155855180802805 -7.763030835989132 24.999874128331182 1.0070322424809088 0.9157365665852694 0.26048553432333843 0.06677612834483722 55.05290641711012 864755.8047410091 0.03316605093832054 0.01725185381922357 1.7257153575546062e-08 7.763030835989132 -0.09129567589563947 HLEFSHDQYR ddPTM_A459_Selumetinib_30min_R1 2 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 ; 154.85 0.00030547 12150200.0 2504.1 3161.8 2754.3 2872.1 3006.2 2622.7 2838.7 2459.6 1249.1 2071.7 False True 2562.440657869594 2791.61498611906 2380.281188286937 2370.541650994203 2734.2897407877167 2596.31801922107 2624.574573549518 2394.363418093228 2119.631469345574 2337.6228750668747 1.096173675061375 1.1942110149136855 1.0182485864914552 1.014082158537393 1.1696881348791106 1.1106659020637768 1.122753632137705 1.0242727531594378 0.9067465466536964 1.0 11.190826485636904 -7.974809886950768 4.064511452045372 0.9544905185489565 1.1027514652021722 0.528340947176082 0.05735666064456449 0.1680240637277783 6.192247414708789 0.03822632690530818 0.015790676421897732 1.0597175165611933e-08 7.974809886950768 0.14826094665321565 HLEFSHDQYR ddPTM_A459_Selumetinib_30min_R2 2 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 ; 130.41 0.0015699000000000002 21004000.0 37113.0 29682.2 27692.5 25329.4 27481.0 19873.6 29006.0 48845.0 29011.0 37225.0 False True 35050.40803511027 31958.72929668424 25910.794699314254 21879.492024347823 24028.591096742883 22611.008005421336 30354.8364742986 48987.130863274935 34814.01063506705 36150.21752783467 0.9695766839610971 0.8840535820310597 0.716753493374242 0.6052381844590898 0.6646873169778724 0.6254736361686202 0.8396861360772232 1.3550992003175693 0.9630373761447277 1.0 15.141716707925957 -7.578738581648695 7.967689823038336 1.1175838624525898 0.7388318695791377 0.5604187642339193 0.14325530354150537 0.1832206452552913 22.84778541677429 0.07006112239233785 0.04032245032510962 2.637918771569775e-08 7.578738581648695 -0.37875199287345207 HLEINPDHPIVETLR ddPTM_A459_Selumetinib_30min_R1 4 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;;; 161.04 6.9826e-05 76943100.0 7280.799999999999 9091.9 8520.2 9014.1 7789.5 7142.099999999999 7910.199999999999 7276.9 4655.030000000001 6843.199999999999 False True 7450.42847402937 8027.416121290366 7363.203638108539 7439.956650613427 7084.941100347919 7070.256958507949 7313.5272454614405 7083.89297329753 7899.2459200606245 7721.591378412717 0.9648825104703884 1.0396064396430824 0.9535862851657595 0.9635263362178609 0.9175493435401563 0.9156476446389399 0.9471528454494363 0.9174136037685181 1.0230075036273711 1.0 12.91468249447984 -5.39203504541645 7.733259939998722 0.948758521203526 1.002043724304413 0.19057384113300369 0.037693137214330964 0.34721311695731366 20.022238012321182 0.009526074610287951 0.019924571371672146 4.0547581423566065e-06 5.39203504541645 0.05328520310088691 HLEINPDHPIVETLR ddPTM_A459_Selumetinib_30min_R2 2 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 134.37 0.00025754 59659000.0 83617.0 79451.0 82442.0 89725.0 98371.0 76666.0 77581.0 82355.0 69677.0 81864.0 False True 78969.90188537215 85544.63622476989 77137.77147606286 77504.3002157419 86012.75553210208 87226.04559534407 81188.670223835 82594.6394153959 83614.34693804309 79500.3736117838 0.9933274310256447 1.0760281032451675 0.9702818738027824 0.9748922765345842 1.08191636874714 1.0971778072551743 1.0212363355711445 1.0389213995235043 1.0517478489641903 1.0 16.27867401990369 -4.654868748303635 19.38754968796774 1.0350321577619401 0.9932262961073619 0.08183849938016452 0.0415480460884071 49895.632322225254 9020995.201424241 0.01091826022105226 571.9420408111217 2.2137636481816703e-05 4.654868748303635 -0.041805861654578225 HLEINPDHSIIETLR ddPTM_A459_Selumetinib_30min_R1 4 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ;;; 150.9 0.00014483 92414900.0 7024.46 8777.46 8444.67 7892.5199999999995 7706.720000000001 7468.52 7866.82 7087.759999999999 4532.22 6668.280000000001 False True 7188.116250780178 7749.790902669549 7297.930197251944 6514.239542949325 7009.648536731929 7393.393469673601 7273.419433786878 6899.769580510839 7690.846319748135 7524.21869254764 0.9553305857390411 1.0299794861551974 0.9699253165621272 0.8657695648056258 0.9316114832859169 0.9826127830383752 0.9666677340187937 0.9170081123964025 1.0221455056012037 1.0 12.877326066280876 -8.277946183955912 24.852686616233598 1.0110727650974314 0.9534427181807089 0.24578095552734192 0.041103271261530426 1364.931506706384 2055023.0361959846 0.04222819354656522 0.011025563559215811 5.27295197697362e-09 8.277946183955912 -0.057630046916722466 HLEINPDHSIIETLR ddPTM_A459_Selumetinib_30min_R2 2 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ; 118.16 0.0011599 20044900.0 18273.7 19194.2 26279.0 22933.0 26830.0 21287.3 19823.8 19643.6 20041.3 19071.0 False True 17258.120909417044 20666.333420919484 24588.237750411827 19809.48583836841 23459.37553675673 24219.432348130464 20745.64598011448 19700.759623826958 24050.120000709023 18520.370677591276 0.931845329116361 1.1158703991775238 1.3276320532915882 1.0696052570015189 1.2666795900117378 1.3077185532487623 1.1201528490580202 1.0637346285765161 1.2985766008349102 1.0 14.176825353383615 -4.82885413321167 3.7616323723274814 1.1872143223357012 0.9177886699140348 0.3139191710223964 0.11056152853486541 0.2662682731207352 6.425156808970251 0.02678720334160248 0.18090083142063046 1.4830161031518098e-05 4.82885413321167 -0.2694256524216664 HLELYDR ddPTM_A459_Selumetinib_30min_R2 2 HLELYDR 7 0 H0Y8P4;Q8TED0-3;Q8TED0;Q8TED0-2 H0Y8P4 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 ; 127.12 0.007670399999999998 3221900.0 10590.3 10202.0 10738.3 14458.0 14024.7 9192.9 7916.3 11099.3 9657.0 9699.8 False True 10001.733522329865 10984.460595399682 10047.409468977028 12488.795458558863 12262.791803591215 10459.138530162516 8284.423635850862 11131.597125411963 11588.66983912456 9419.741570892973 1.0617842800735902 1.1661106106500516 1.0666332397083536 1.3258108372260737 1.3018182835804408 1.1103424071082038 0.8794746197124721 1.1817306283442668 1.2302534790268114 1.0 13.201471764934816 -6.9866724074840425 24.90115746302766 1.0747088345076106 1.1868593714548341 0.16509424325403776 0.1193303326936267 438.4346397540193 819163.563025242 0.044599250287815785 0.039312541864459746 1.0311636438389556e-07 6.9866724074840425 0.11215053694722354 HLFS(ph)STENLAAGSWK ddPTM_A459_Selumetinib_30min_R2 3 HLFSSTENLAAGSWK 15 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.693)S(0.251)T(0.056)ENLAAGSWK;HLFS(0.472)S(0.427)T(0.1)ENLAAGSWK;HLFS(0.45)S(0.45)T(0.1)ENLAAGSWK 107.62 0.0027738000000000003 38462000.0 273710.0 173500.0 224120.0 271794.0 250281.0 245301.0 319152.0 315874.0 298264.0 213214.0 True False 258498.29394794384 186806.89210957137 209700.3632034058 234775.188329198 218838.4632394714 279088.98612922954 333993.2003876903 316793.1410442446 357925.1341924656 207057.9578234988 1.248434480206233 0.9021961487170181 1.0127616702477065 1.133862184274637 1.0568947242588695 1.3478785798087112 1.6130420868556723 1.5299732711277232 1.7286229322205988 1.0 17.6596751250648 -6.8978934038265765 3.2245748082763663 1.5110248237645085 1.0597115967964987 0.47291679917771945 0.19733873620790668 0.18857068434248506 3.9010295249021745 0.07060195195070858 0.06109725306113633 1.265046811009336e-07 6.8978934038265765 -0.4513132269680098 HLFS(ph)STENLAAGSWKEPAEGGGLSSDR ddPTM_A459_Selumetinib_30min_R2 1 HLFSSTENLAAGSWKEPAEGGGLSSDR 27 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.37)S(0.315)T(0.315)ENLAAGSWKEPAEGGGLSSDR 81.477 3.9776e-05 4713600.0 31103.0 31434.0 33815.0 45019.0 36949.0 29129.0 25210.0 23050.0 18751.0 36439.0 True False 29374.41977517407 33844.88672375944 31639.379714988234 38887.334537893315 32307.13629174896 33141.255343265315 26382.314952667297 23117.07168386707 22501.723946714774 35386.911390107925 0.8300927834969346 0.9564238695672224 0.8940983677889651 1.0989185834614519 0.9129685248761245 0.9365399251128098 0.7455387858473068 0.6532661590332868 0.6358770252270425 1.0 15.110928226742718 -7.2715614103084425 4.789616598174789 0.727396096599402 0.944148283907298 0.3634426847005984 0.11349785088834125 0.17695828474752853 11.762548371718879 0.04571091344818646 0.03206275590646515 5.351044833307044e-08 7.2715614103084425 0.21675218730789603 HLFSS(ph)TENLAAGSWK ddPTM_A459_Selumetinib_30min_R1 1 HLFSSTENLAAGSWK 15 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.29)S(0.608)T(0.102)ENLAAGSWK 166.77 5.1139e-05 106040000.0 11232.0 11745.0 7913.4 6611.6 9982.3 9527.2 10896.0 12924.0 5072.3 9514.6 True False 11493.68374633253 10369.889939897632 6838.803745194723 5457.008175102979 9079.402727518205 9431.365018005481 10074.105947580078 12581.213536931562 8607.322633865626 10735.891590052268 1.0705849299915082 0.9659085929580578 0.6370038005535997 0.5082957600055658 0.8457055151275052 0.8784892189806067 0.938357644828922 1.1718834371044826 0.8017333783289182 1.0 13.39015438808509 -7.073873843594309 2.226263670693944 0.994557661754912 0.7898170916509749 0.1868073980795808 0.168992021468928 0.5331077026345429 5.223844165549167 0.08141979327895119 0.06083245377542563 8.435797701705154e-08 7.073873843594309 -0.2047405701039371 HLFSS(ph)TENLAAGSWK ddPTM_A459_Selumetinib_30min_R2 1 HLFSSTENLAAGSWK 15 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.388)S(0.505)T(0.108)ENLAAGSWK 98.227 0.0059649 12366000.0 97386.0 53690.0 69372.0 90992.0 76956.0 79525.0 106030.0 106360.0 96920.0 66673.0 True False 91973.67598704628 57807.85035944024 64908.68104652267 78598.73263004495 67288.09928463111 90478.84689392621 110960.60509445923 106669.4899911541 116306.70817106245 64747.977252742 1.420487247470751 0.8928132246323132 1.0024819894087713 1.2139179626142897 1.0392309094378935 1.397400362651399 1.7137308345761517 1.6474567162889522 1.7962987124225105 1.0 15.982547502803923 -6.93917858434911 3.8363798702402105 1.5914958207463867 1.1020121924253943 0.40436952477584864 0.24165324204876631 0.1924037211152425 5.7738313829878285 0.08570192644966082 0.07342788444243804 1.1503272705919933e-07 6.93917858434911 -0.48948362832099246 HLFSS(ph)TENLAAGSWKEPAEGGGLSSDR ddPTM_A459_Selumetinib_30min_R1 1 HLFSSTENLAAGSWKEPAEGGGLSSDR 27 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.13)S(0.433)T(0.433)ENLAAGS(0.005)WKEPAEGGGLSSDR 66.075 0.00065816 98242000.0 1223.3 1116.7 1888.4 2027.3 2007.1 1200.7 1266.0 1328.2 784.8 1057.8 True False 1251.8005098725596 985.9562448602546 1631.9656522387 1673.2701121341693 1825.558159382287 1188.6220481483729 1170.504600737553 1292.971821398367 1331.7482804758665 1193.5789338445436 1.0487789909633232 0.8260503071082766 1.3672875802039361 1.4018931339082283 1.5294825567188293 0.9958470398935373 0.9806679454096364 1.0832729907804897 1.1157605439518579 1.0 10.221078262644845 HLFSS(ph)TENLAAGSWKEPAEGGGLSSDR ddPTM_A459_Selumetinib_30min_R2 1 HLFSSTENLAAGSWKEPAEGGGLSSDR 27 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.196)S(0.402)T(0.402)ENLAAGSWKEPAEGGGLSSDR 84.602 2.8813000000000007e-05 3372800.0 24841.0 20117.0 22147.0 30304.0 23633.0 18349.0 14250.0 17431.0 13035.0 22288.0 True False 23460.43666640192 21659.909213649826 20722.086131830383 26176.542922684173 20664.011258299353 20876.408194362168 14912.653235839312 17481.72132414261 15642.3642283306 21644.487528821483 1.0838989204601102 1.0007124994208252 0.957384003859512 1.209386126043773 0.9547008784931248 0.9645138590859889 0.6889815809213242 0.8076754555109797 0.7226950606939275 1.0 14.401712022170386 -6.981282136846617 2.608531074980403 0.7900163531555477 1.045665290264241 0.5289305694206731 0.10395632311154152 0.20483881651184405 2.8171154838326613 0.04056373941787805 0.03285193594924323 1.0440417433049519e-07 6.981282136846617 0.2556489371086932 HLFSST(ph)ENLAAGSWK ddPTM_A459_Selumetinib_30min_R1 1 HLFSSTENLAAGSWK 15 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.006)S(0.245)T(0.749)ENLAAGSWK 227.74 2.3496999999999996e-13 63364000.0 3982.5 4308.8 3247.4 2924.4 4107.2 4129.2 4468.6 5235.8 2127.6 3910.6 True False 4075.2845014039626 3804.323692893224 2806.4209166913515 2413.7084377867905 3735.704485185055 4087.663997013626 4131.529904309502 5096.929575724723 3610.3818062442083 4412.563602469718 0.9235639117185802 0.8621572481729076 0.6360069042677581 0.5470081918900466 0.8466063770942988 0.9263694226924583 0.9363105615060322 1.1550948688585394 0.8182050462056735 1.0 12.107401358129495 -6.696577320221192 2.8552440673580213 0.9808104444704897 0.7401173063829144 0.41009223633381464 0.12638028533621332 0.2704837928102504 4.485341160255523 0.04852156815059404 0.04679665395330601 2.0110491264029772e-07 6.696577320221192 -0.2406931380875753 HLFSST(ph)ENLAAGSWKEPAEGGGLSSDR ddPTM_A459_Selumetinib_30min_R1 1 HLFSSTENLAAGSWKEPAEGGGLSSDR 27 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 HLFS(0.054)S(0.414)T(0.532)ENLAAGSWKEPAEGGGLSSDR 103.35 4.6667e-07 88842000.0 1497.9 1478.2 2117.6 2038.3 1678.4 1708.7 1712.4 1802.9 938.84 1345.8 True False 1532.7981555939732 1305.1316568034633 1830.0415511441793 1682.3491686297418 1526.5890163455867 1691.512029375468 1583.2322893388505 1755.0812353554556 1593.142909839403 1518.5465392021042 1.0093850376158753 0.8594610853936843 1.2051270763856503 1.107868033806659 1.0052961677076477 1.113902001491667 1.042597146986838 1.155763876869809 1.0491235327410475 1.0 10.568475408410935 -5.251653148704809 24.99666086807221 1.0880164561342343 0.9344230648357236 0.4259073890913144 0.06983730112435482 598.2946009193703 1528197.579829635 0.01693416631650976 0.043683949090794046 5.602048330586336e-06 5.251653148704809 -0.15359339129851068 HLGGSGSVVPGS(ph)PCLDR ddPTM_A459_Selumetinib_30min_R1 3 HLGGSGSVVPGSPCLDR 17 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 HLGGSGSVVPGS(1)PCLDR;HLGGSGSVVPGS(1)PCLDR;HLGGSGSVVPGS(1)PCLDR 190.18 7.4276e-08 18364200.0 5886.2 6797.4 7267.099999999999 7972.8 8973.1 6421.299999999999 8529.9 7114.8 3226.2400000000002 5707.299999999999 True False 6023.33700744859 6001.557247974471 6280.2677353229465 6580.500147991562 8161.484689329476 6356.7075520739145 7886.482775538115 6926.092391872538 5474.693644753392 6439.887548809757 0.9353171094675161 0.9319351001841173 0.9752138818765069 1.0218346357938801 1.2673334165342547 0.9870836259010118 1.2246305103566166 1.0754989647532964 0.850122553112786 1.0 12.652819781357426 -5.809379988589771 3.333909274051258 1.0794239864676574 0.9417403786882789 0.17886820302405093 0.11206038610678416 0.368341092747962 8.347936716925316 0.03239218642268844 0.05361103658109029 1.5510293335728677e-06 5.809379988589771 -0.1376836077793785 HLGGSGSVVPGS(ph)PCLDR ddPTM_A459_Selumetinib_30min_R2 2 HLGGSGSVVPGSPCLDR 17 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 HLGGSGSVVPGS(1)PCLDR;HLGGSGSVVPGS(1)PCLDR 114.1 0.0011567 32479000.0 90363.0 58993.0 121013.0 131959.0 159712.0 76942.0 81533.0 97926.0 64713.0 90109.0 True False 85340.98621174986 63517.57340760767 113227.15532899203 113985.956558028 139647.55071660408 87540.06209006558 85324.44605457455 98210.94844747803 77657.40823229447 87507.3190387015 0.9752439812949412 0.7258544097267569 1.2939164011974302 1.302587689923581 1.5958385224308234 1.0003741750030029 0.9750549667375646 1.1223169618994118 0.887439006078443 1.0 16.41711606734296 -11.08856739725792 3.1644499245911826 0.9954667014719495 1.1074065140523772 0.013784572760508707 0.23496324796382664 76076889.3526482 63133738.616929375 2745274.9474957506 0.06345112403344282 8.15516219045224e-12 11.08856739725792 0.11193981258042773 HLLAPGPQDIY(ph)DVPPVR ddPTM_A459_Selumetinib_30min_R1 1 HLLAPGPQDIYDVPPVR 17 0 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4;H3BN62 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 HLLAPGPQDIY(1)DVPPVR 180.27 5.105699999999999e-07 4847900.0 2844.9 3399.3 3593.1 2812.2 3146.9 3068.9 2874.6 3035.7 1824.8 2256.9 True False 2911.1806347882307 3001.3083757083045 3105.176755485528 2321.102061531942 2862.2634506303193 3038.029652338255 2657.7666076462638 2955.1833746566963 3096.552321881195 2546.5950990676397 1.1431658828896958 1.1785573516603187 1.219344510881371 0.9114531251480633 1.1239570246869053 1.1929771063529258 1.0436549605468597 1.1604449312490428 1.2159578580100565 1.0 11.314353878352076 HLLGAEHGDEPR ddPTM_A459_Selumetinib_30min_R1 2 HLLGAEHGDEPR 12 0 U3KQC1;K7EIR0;A0A0A0MQU0;Q9BV38 U3KQC1 WDR18 WD repeat-containing protein 18 0 ; 161.19 0.00025675 6620300.0 1354.1100000000001 1768.2800000000002 1888.21 2085.7 1647.01 1574.3600000000001 1422.08 1321.05 992.3299999999999 1241.84 False True 1385.6581283606079 1561.2489555489312 1631.8014531951032 1721.4716484379387 1498.0382363032327 1558.523367804508 1314.8113606768231 1286.0114626248408 1683.9115330843738 1401.242260545952 0.9888783455765371 1.1141891730703566 1.1645391372647589 1.2285324935655444 1.0690786871640363 1.1122440506449445 0.93831837484301 0.9177652564687744 1.2017276244782171 1.0 10.452490689305414 -7.1631338182647255 7.893434957132309 1.0077920043761448 1.119100027382736 0.21377434030883535 0.0917341186765037 0.43350116659899396 31.050777564620876 0.03562688503344865 0.0275727851624728 6.86856767642883e-08 7.1631338182647255 0.11130802300659126 HLLGAEHGDEPR ddPTM_A459_Selumetinib_30min_R2 2 HLLGAEHGDEPR 12 0 U3KQC1;K7EIR0;A0A0A0MQU0;Q9BV38 U3KQC1 WDR18 WD repeat-containing protein 18 0 ; 120.86 0.0022163 5734000.0 9076.1 5749.9 9649.8 8792.0 9015.5 6654.6 6713.5 9018.0 5901.1 9240.3 False True 8571.686696506995 6190.898841157484 9028.94237390784 7594.514432954044 7882.892290407395 7571.210745555746 7025.691052547877 9044.240886989728 7081.4848905102945 8973.508529817344 0.9552213237469862 0.6899083920839043 1.0061774994592472 0.846326095051768 0.8784626731243383 0.8437291523597469 0.7829369113767238 1.0078823524753282 0.7891545282405207 1.0 13.131456455860247 -11.751493679375223 2.2412203054757667 1.4350548332315889 0.8663182318409312 0.1473786736385111 0.09622335088867766 10407448.964663498 1900089.4404884127 22938580.59038887 0.022621850806100754 1.7721738367691796e-12 11.751493679375223 -0.5687366013906577 HLLS(ph)PQLVQYQCGDSGK ddPTM_A459_Selumetinib_30min_R1 3 HLLSPQLVQYQCGDSGK 17 0 Q9P209 Q9P209 CEP72 Centrosomal protein of 72 kDa 1 HLLS(1)PQLVQYQCGDSGK;HLLS(1)PQLVQYQCGDSGK;HLLS(1)PQLVQYQCGDSGK 238.45 1.7887e-22 96293000.0 10290.0 11033.4 12318.0 12931.0 11781.0 10218.3 10496.900000000001 10046.099999999999 5578.61 9209.6 True False 10529.736979145453 9741.604398711503 10645.283257930681 10672.843594932641 10715.410630104485 10115.513179474077 9705.110381897328 9779.644793668223 9466.493724446333 10391.74186910069 1.013279305027301 0.9374371035598625 1.024398353233146 1.0270504915704068 1.0311467283426474 0.9734184419603451 0.9339252749103569 0.9410977405768223 0.9109631324267653 1.0 13.343149879343805 -7.013172831624914 4.625159961211528 0.9424852094874586 1.0049909266997872 0.4296908911505506 0.032534876951610024 0.1902807388660061 10.563750860128609 0.012602358877788161 0.01028142252589724 9.701238204022401e-08 7.013172831624914 0.06250571721232856 HLLS(ph)PQLVQYQCGDSGK ddPTM_A459_Selumetinib_30min_R2 2 HLLSPQLVQYQCGDSGK 17 0 Q9P209 Q9P209 CEP72 Centrosomal protein of 72 kDa 1 HLLS(1)PQLVQYQCGDSGK;HLLS(1)PQLVQYQCGDSGK 193.72 1.1228e-20 6881000.0 51311.0 53540.0 49329.0 55321.0 60394.0 38808.0 49226.0 49848.0 43354.0 52524.0 True False 48459.34003420747 57646.34584176624 46155.22584535427 47786.184365952045 52806.76579078966 44153.449736051385 51515.10653946848 49993.04942721933 52026.01141197124 51007.49564625894 0.9500435067480447 1.1301544040026639 0.904871436258005 0.9368463156347266 1.0352746223223503 0.8656266922465492 1.009951692134228 0.9801118207003364 1.019967962606433 1.0 15.638421648929336 -10.591451515667385 5.384633525035289 1.0000001812874415 0.9812171276840762 0.006216566553035818 0.07040129691756242 1.488820107062218e-07 2.5656228628671008e-08 0.0662211360706368 0.01606082954347144 2.561819247835592e-11 10.591451515667385 -0.018783053603365296 HLLS(ph)PVGR ddPTM_A459_Selumetinib_30min_R2 1 HLLSPVGR 8 0 Q9NXE4-3;Q9NXE4-6;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C0W5;H7C1Q6;Q9NXE4-5;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 HLLS(1)PVGR 71.34899999999998 0.043592 0.0 4021.9 2816.2 4082.6 4786.8 3398.2 2648.7 7312.9 5697.7 5143.9 3876.2 True False 3798.3788989413392 3032.1934844897646 3819.9299607987864 4134.8295823094195 2971.2877357065513 3013.534382495345 7652.964340236446 5714.279363694986 6172.823732574591 3764.2840344229103 1.0090574633068718 0.8055166551624524 1.01478260563417 1.0984371913750437 0.7893367526295261 0.8005597757602104 2.033046462555182 1.5180255558401357 1.6398400535471087 1.0 11.87815977553225 -7.243217446216163 24.94564756196625 1.590896838026376 0.9209610840814016 0.5926913049385696 0.25408095185743457 497.63105016923123 681252.9694297168 0.09238381181660094 0.07141448376500241 5.711925755582899e-08 7.243217446216163 -0.6699357539449743 HLLTDLPLPPELPGGDLS(ph)PPDSPEPK ddPTM_A459_Selumetinib_30min_R1 1 HLLTDLPLPPELPGGDLSPPDSPEPK 26 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 HLLTDLPLPPELPGGDLS(0.825)PPDS(0.175)PEPK 135.47 2.9389e-09 132570000.0 2583.1 2889.8 3068.6 3224.4 2631.3 2835.4 2649.6 2456.9 1382.9 2569.4 True False 2643.281204162355 2551.4608725684293 2651.9009746132556 2661.319069484247 2393.2993795937464 2806.878450337219 2449.738538794801 2391.735030864065 2346.680296980221 2899.207518075412 0.911725424165929 0.8800545861795267 0.9146985712749784 0.9179470779142147 0.825501232551472 0.9681536878051821 0.8449683313531889 0.8249616545047374 0.8094212926634599 1.0 11.501442886286098 HLLVHAPEDK ddPTM_A459_Selumetinib_30min_R2 1 HLLVHAPEDK 10 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 135.43 0.0011089 3315900.0 40811.0 26560.0 34864.0 38400.0 37236.0 33632.0 42814.0 45329.0 36828.0 28013.0 False True 38542.887999377155 28597.066596139543 32620.888197053093 33169.853756305194 32558.080785936407 38264.5027191012 44804.935834331525 45460.899885380095 44194.6290602961 27204.191903485098 1.4167995923613328 1.0512007376508767 1.1991125600343258 1.2192920074224238 1.1968038198468018 1.4065664164866878 1.6469864641923664 1.6710990735055118 1.6245521725875776 1.0 14.731541353539937 -6.921293951244228 3.557903486406294 1.54125358642649 1.2066362783003675 0.27526412108993725 0.19946771124756904 0.24305917416652273 6.122095972877899 0.07090066101402222 0.060997669335925986 1.1986876994383448e-07 6.921293951244228 -0.33461730812612256 HLNEIDLFHCIDPNDSK ddPTM_A459_Selumetinib_30min_R1 1 HLNEIDLFHCIDPNDSK 17 0 A0A087WYT3;Q15185-4;Q15185;Q15185-3 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 0 66.977 0.022514 45743000.0 4152.2 4813.7 4964.7 5743.4 4627.3 4567.2 4199.6 3860.8 2561.9 3847.2 False True 4248.938181225241 4250.109766171585 4290.521009145028 4740.423006970544 4208.761532016169 4521.25811468581 3882.820790882644 3758.3990423541773 4347.357186227223 4341.025594901424 0.9787867148757796 0.9790566015467358 0.9883657479892047 1.0920053114955637 0.9695316095255002 1.0415184190565638 0.894447799488456 0.8657859669771247 1.0014585473380382 1.0 12.08382021347921 -7.260863207722593 24.999646336852674 0.9292385752577347 1.008034204093685 0.2790743383278942 0.05215006506832288 60.68559536534818 2633197.84982282 0.020563958613496972 0.014954111408575459 5.484496861288136e-08 7.260863207722593 0.07879562883595026 HLPPPLPSKT(ph)PPPPPPK ddPTM_A459_Selumetinib_30min_R2 1 HLPPPLPSKTPPPPPPK 17 1 A0A096LNH6;Q14185 A0A096LNH6 DOCK1 Dedicator of cytokinesis protein 1 1 HLPPPLPS(0.133)KT(0.867)PPPPPPK 79.639 0.0099135 2883400.0 74341.0 66158.0 72562.0 80083.0 71918.0 53661.0 63121.0 60341.0 45658.0 68301.0 True False 70209.42483060199 71232.10586850165 67893.43991953194 69175.55724911959 62883.0178849225 61052.315663941765 66056.25157188863 60516.582320009715 54790.87579111003 66328.97266268992 1.058503124835745 1.0739214404954855 1.0235864840662916 1.042916156728459 0.9480475177070581 0.9204471773506561 0.9958883564775202 0.9123702643151342 0.8260474057052587 1.0 16.01735156039353 -6.236377966736132 1.3507916554727788 0.9248478100075641 1.0618060489318533 0.5889472886717895 0.047260323320089136 0.3061350115433755 1.1288774143804488 0.018482378848131423 0.026673172644724623 5.802591977947892e-07 6.236377966736132 0.13695823892428916 HLPS(ph)PPLTQEVDLHSIAGPPVPPR ddPTM_A459_Selumetinib_30min_R1 1 HLPSPPLTQEVDLHSIAGPPVPPR 24 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 HLPS(0.999)PPLT(0.001)QEVDLHSIAGPPVPPR 92.336 1.7794e-05 42986000.0 4110.6 4723.7 4986.5 5575.3 4245.2 4138.9 4001.8 3984.8 2610.3 4029.9 True False 4206.368982164753 4170.647008011446 4309.360688883857 4601.678516342738 3861.2224095509364 4097.266423820524 3699.941004132338 3879.110159545414 4429.488451231085 4547.176919550128 0.9250506537539576 0.9171947961998509 0.9477002467962474 1.0119858096038192 0.8491471693019025 0.9010571825795343 0.8136786999038491 0.8530809836906875 0.974118344106416 1.0 12.150755421577648 -6.27744034235194 24.971253232947596 0.8870532026351097 0.9479064038772531 0.14258276854197294 0.05837810486021696 1315.2365194410759 2052566.155000161 0.017942392985495683 0.020413391738197745 5.279097190757327e-07 6.27744034235194 0.06085320124214344 HLPS(ph)PPLTQEVDLHSIAGPPVPPR ddPTM_A459_Selumetinib_30min_R2 5 HLPSPPLTQEVDLHSIAGPPVPPR 24 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 HLPS(0.999)PPLT(0.001)QEVDLHSIAGPPVPPR;HLPS(0.992)PPLT(0.008)QEVDLHSIAGPPVPPR;HLPS(0.834)PPLT(0.166)QEVDLHSIAGPPVPPR;HLPS(0.988)PPLT(0.012)QEVDLHSIAGPPVPPR;HLPS(0.884)PPLT(0.116)QEVDLHSIAGPPVPPR 85.969 5.2633e-05 23713500.0 94679.0 82876.0 99277.0 97150.0 104274.1 78471.4 83664.5 87046.9 68215.2 89318.0 True False 89417.12021006663 89232.32271165888 92889.62590462502 83918.00240690247 91174.25533571848 89280.12305755471 87555.06502806164 87300.19206761 81860.14609193844 86739.15726396591 1.030873748726323 1.0287432519099273 1.0709076365815027 0.9674754177230698 1.0511314406509116 1.02929433342148 1.0094064525161657 1.0064680684173208 0.9437507657910533 1.0 16.4043958059531 -7.859401274620018 2.094530914798677 0.9731661149716875 1.028783206186863 0.36532785385554534 0.028419966508783152 0.34130671364627546 2.8781584280104004 0.02053588280586746 0.007815843640135387 1.3822885969922789e-08 7.859401274620018 0.05561709121517544 HLPS(ph)PPTLDSIITEYLR ddPTM_A459_Selumetinib_30min_R1 3 HLPSPPTLDSIITEYLR 17 0 Q9Y4B6-3;Q9Y4B6-2;Q9Y4B6 Q9Y4B6-3 VPRBP Protein VPRBP 1 HLPS(1)PPTLDSIITEYLR;HLPS(0.998)PPT(0.002)LDSIITEYLR;HLPS(1)PPTLDSIITEYLR 207.92 4.9956e-09 59256200.0 4967.18 5502.11 5879.43 6904.6 5618.7699999999995 4767.17 5536.78 5394.55 2927.3100000000004 4233.43 True False 5082.905629550213 4857.9204033384585 5081.0356993972555 5698.841225394162 5110.553245574415 4719.216598044043 5119.1362269128485 5251.469010032047 4967.431267736761 4776.831977600211 1.064074611245541 1.01697535649537 1.0636831530234963 1.1930168890422541 1.0698624673296253 0.9879385794128115 1.0716592609741749 1.0993623042756226 1.039900773364087 1.0 12.22183841637055 -6.531122266850374 24.997771484580497 1.0458558542337881 1.084799246513115 0.14213046852311795 0.05119367851288867 474.23115277359165 1438051.232925729 0.0181400582543365 0.018165869162062125 2.9435928079605435e-07 6.531122266850374 0.03894339227932697 HLPS(ph)PPTLDSIITEYLR ddPTM_A459_Selumetinib_30min_R2 1 HLPSPPTLDSIITEYLR 17 0 Q9Y4B6-3;Q9Y4B6-2;Q9Y4B6 Q9Y4B6-3 VPRBP Protein VPRBP 1 HLPS(1)PPTLDSIITEYLR 91.889 0.005415 15588000.0 82928.0 89362.0 93012.0 97031.0 106560.0 81754.0 75644.0 102200.0 81236.0 74472.0 True False 78319.19374708665 96215.7780558818 87027.70918380862 83815.21041218862 93172.98014151305 93014.87141107877 79161.59588574244 102497.38507987911 97485.46992348772 72321.79985850633 1.082926502110206 1.3303841752296368 1.2033399245327632 1.1589204164742652 1.2883111361138815 1.2861249525462213 1.0945744718828596 1.4172405178025114 1.3479403183301957 1.0 16.142142961819005 -6.270148068697145 24.27764200054715 1.2550257022772167 1.2043169389140864 0.017872427433450522 0.12668660175831273 1844.2220372639192 5141214.977172705 0.03824021814197608 0.04404252157996338 5.368487315424198e-07 6.270148068697145 -0.05070876336313024 HLPSPPTLDSIITEYLR ddPTM_A459_Selumetinib_30min_R1 1 HLPSPPTLDSIITEYLR 17 0 Q9Y4B6-3;Q9Y4B6-2;Q9Y4B6 Q9Y4B6-3 VPRBP Protein VPRBP 0 113.11 0.0026024 6841600.0 1723.8 2034.1 2601.5 2423.5 2030.8 2219.0 2182.0 1972.0 1318.9 1668.7 False True 1763.9611860690889 1795.9466263725653 2248.230589016615 2000.2812197292733 1847.1144985668611 2196.678874690797 2017.4099832617208 1919.696154041245 2238.0769713552763 1882.8938995144526 0.9368351485572112 0.9538225318142947 1.194029355343056 1.0623440971608074 0.9809976542189562 1.1666503753914446 1.0714411384422438 1.0195455806279274 1.1886367956964627 1.0 10.878735991487837 -5.121017832957366 8.516792673417482 1.0839045180413198 0.9412040995608465 0.37567671379489265 0.07236465979305749 0.28386699443023655 18.279291812376417 0.017720932411211327 0.04731354121185921 7.568018186609948e-06 5.121017832957366 -0.14270041848047332 HLQLAIR ddPTM_A459_Selumetinib_30min_R1 2 HLQLAIR 7 0 H0YFX9;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q9BTM1;Q16777;Q93077;Q7L7L0;Q6FI13;P20671;P0C0S8;P04908;A0A3B3IS11;Q96QV6;Q9BTM1-2;Q71UI9-3;Q71UI9-4;Q71UI9;P0C0S5;C9J386;C9J0D1;A0A494C189;Q71UI9-2;P16104 H0YFX9;Q71UI9-3;P16104 H2AFJ;HIST1H2AJ;HIST1H2AH;HIST2H2AC;HIST1H2AC;HIST3H2A;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AB;HIST1H2AA;H2AFV;H2AFZ;H2AFX Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A.J;Histone H2A type 2-C;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-B/E;Histone H2A type 1-A;Histone H2A.V;Histone H2A.Z;Histone H2AX 0 ; 158.38 0.0015322 53947000.0 6111.2 5897.0 6549.4 7695.5 7356.1 5008.0 4309.3 4707.1 3442.8999999999996 5596.8 False True 6253.579069674798 5206.576498559075 5660.027453279038 6351.625387425887 6690.742053824937 4957.6240669001845 3984.246031562664 4582.252417184351 5842.349840533083 6315.203797448606 0.9902418465420381 0.8244510653262804 0.8962541249366704 1.0057672865588274 1.0594657383072976 0.7850299413778389 0.6308974594251942 0.7255905849048955 0.9251245134628023 1.0 12.624613576525158 -6.7921755892488616 23.94263369874527 0.7847757547879597 0.9475006737591544 0.26313785598393424 0.11345754150481345 157.16111963471351 122422.52192261306 0.040915846500272 0.03608965045425795 1.6137059887595022e-07 6.7921755892488616 0.16272491897119468 HLQQGSES(ph)PMMIGELR ddPTM_A459_Selumetinib_30min_R2 5 HLQQGSESPMMIGELR 16 0 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 HLQQGS(0.012)ES(0.988)PMMIGELR;HLQQGSES(1)PMMIGELR;HLQQGSES(1)PMMIGELR;HLQQGS(0.233)ES(0.767)PMMIGELR;HLQQGS(0.005)ES(0.995)PMMIGELR 161.31 3.1542e-05 25415100.0 94911.0 82865.0 109421.0 114669.0 130754.0 86686.0 89361.0 96690.4 77557.0 97863.0 True False 89636.22657883633 89220.47904702957 102380.97198857715 99050.88438494189 114327.51356440889 98626.2096428403 93516.4635654623 96971.75305604262 93070.56712363931 95037.44091138993 0.9431675108172417 0.9387929450900944 1.0772698739229953 1.042230129884221 1.2029734015145088 1.037761630543024 0.9839960195545906 1.0203531589876897 0.9793042219057174 1.0 16.53620836852742 -2.387311240699549 13.582921139066592 1.027242569425721 0.9786101518085853 0.0 0.07319102163934035 0.0 0.0 0.018022206142326906 0.0 0.004099102321695741 2.387311240699549 -0.04863241761713566 HLS(ph)LPAGQVVPK ddPTM_A459_Selumetinib_30min_R2 2 HLSLPAGQVVPK 12 0 Q8IXS8 Q8IXS8 FAM126B Protein FAM126B 1 HLS(1)LPAGQVVPK;HLS(1)LPAGQVVPK 114.21 0.0037259 12016600.0 159297.0 152358.0 185869.0 182671.0 196692.0 158873.0 158661.0 166125.0 142999.0 170334.0 True False 150443.91045641567 164043.36869181565 173910.3908988662 157790.89467494865 171981.79251120976 180756.31364449853 166039.0508808073 166608.3962465257 171602.7957258954 165416.01483911832 0.9094881810732514 0.9917018545717131 1.0513515941489064 0.9539033740379625 1.0396925151320882 1.0927376881875677 1.0037664795775363 1.0072083794822833 1.03740134165845 1.0 17.335739390992565 -4.811751804723937 3.034833673778066 1.023506173656351 0.8952415429865763 0.4919430889963742 0.03484809725625813 0.29534189898837687 4.156974692621891 0.009086471088316117 0.08950243851987907 1.5425817722955482e-05 4.811751804723937 -0.12826463066977478 HLS(ph)QEDNDLNK ddPTM_A459_Selumetinib_30min_R2 2 HLSQEDNDLNK 11 0 F5H777;A0A2R8Y4L3;A0A2R8YE98;A0A2R8Y7C3;Q8N4S0-2;Q8N4S0 F5H777 CCDC82 Coiled-coil domain-containing protein 82 1 HLS(1)QEDNDLNK;HLS(1)QEDNDLNK 125.84 0.003273 11968600.0 33396.0 27272.0 31544.0 32591.0 31386.0 29782.0 30801.0 35932.0 25285.0 28904.0 True False 31539.98401478032 29363.674706698723 29514.493382510387 28152.049577389127 27443.010085599948 33884.20016592152 32233.30753102364 36036.55617113719 30342.70652192862 28069.46641838907 1.1236403123829108 1.0461073348890515 1.051480385931905 1.0029420993534082 0.9776819294157044 1.2071551222549444 1.1483405865494731 1.2838347417793687 1.0809862243070745 1.0 14.776714019001576 -6.766122966952599 24.99979529535648 1.1620703387066456 1.0392269986218008 0.2883739607286 0.07894089674303419 127.58797953215654 681027.0838975249 0.026406148819445523 0.02404998862794941 1.713472083124786e-07 6.766122966952599 -0.12284334008484477 HLSLGS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 HLSLGSR 7 0 Q5TEC3 Q5TEC3 ZNF697 Zinc finger protein 697 1 HLSLGS(1)R 74.415 0.037128 824170.0 0.0 56.387 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 49.78518382639488 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 HLT(ph)PEPDIVASTK ddPTM_A459_Selumetinib_30min_R1 3 HLTPEPDIVASTK 13 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 HLT(1)PEPDIVASTK;HLT(1)PEPDIVASTK;HLT(1)PEPDIVASTK 169.94 0.00032643 25257000.0 18303.0 20788.1 22744.1 24381.1 19321.9 19144.9 20529.3 18216.2 10941.199999999999 17526.600000000002 True False 18729.42428856163 18354.219587874497 19655.576144398547 20123.398574929408 17574.23755655851 18952.319688178395 18980.758372765747 17733.047201443256 18566.417286369215 19776.309833541094 0.9470636557683819 0.9280912234063659 0.993895034505488 1.0175507333931249 0.8886510023600147 0.9583344844261495 0.9597725021770203 0.896681299529783 0.938821116914346 1.0 14.271485630645662 -6.260383095986699 24.999965378394556 0.9370784767395447 0.9701277256008145 0.13950168458699563 0.03744194313852521 193.88003081986795 4588740.521547277 0.01146102390567777 0.014001094060890326 5.490563314899296e-07 6.260383095986699 0.03304924886126981 HLT(ph)PEPDIVASTK ddPTM_A459_Selumetinib_30min_R2 5 HLTPEPDIVASTK 13 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 HLT(1)PEPDIVASTK;HLT(1)PEPDIVASTK;HLT(1)PEPDIVASTK;HLT(1)PEPDIVASTK;HLT(1)PEPDIVASTK 190.41 0.00014975 42015400.0 429678.0 415846.0 445851.0 420019.0 465528.0 335332.0 363142.0 382520.0 264430.0 402549.0 True False 405798.2168973162 447740.0510443625 417165.43206586415 362811.6876268115 407044.21076687635 381520.9391591831 380028.8225522216 383633.06987040536 317323.3887915206 390926.3644220914 1.0380425927455927 1.1453309159801977 1.0671202303854899 0.9280819117000666 1.0412298780835927 0.9759406729274646 0.9721237991047759 0.9813435592596377 0.8117216378092624 1.0 18.57653735898316 -5.915343205245915 0.5796197463635451 0.9335647776685375 1.1198793823502688 0.4114463189911324 0.06461837555133743 1.2858297192876413 0.7591265387092733 0.04333402434507382 0.138607584740116 1.2152252780293842e-06 5.915343205245915 0.18631460468173133 HLTDAYFK ddPTM_A459_Selumetinib_30min_R2 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 87.696 0.045113 6027000.0 58232.0 55019.0 82286.0 90833.0 111190.0 74228.0 69571.0 74975.0 72507.0 85029.0 False True 54995.69856116568 59238.78038603168 76991.8083462227 78461.38870433495 97221.31814878808 84452.23322530453 72806.18935232123 75193.16483722052 87010.42601484979 82573.99183812624 0.6660171966613457 0.7174024056165325 0.9323978002317417 0.9501949337528284 1.177384258464526 1.0227461619011988 0.8817084863118487 0.9106155965503677 1.0537267737451823 1.0 16.333399830024348 -5.283787939646025 2.1459091361972025 0.9990569884296094 0.6603321017370749 0.7162422637580597 0.076825584507332 0.20029763283728538 1.7036900890008337 0.023667063168259308 0.08501553974922962 5.202499658237182e-06 5.283787939646025 -0.33872488669253453 HLTGEFEK ddPTM_A459_Selumetinib_30min_R1 1 HLTGEFEK 8 0 F5H018;B5MDF5;J3KQE5;P62826;H0YFC6 F5H018 RAN GTP-binding nuclear protein Ran 0 113.71 0.012257 0.0 4606.9 4956.2 4306.1 4694.1 5353.2 4212.7 5253.4 4421.0 1595.8 3571.7 False True 4714.231806533058 4375.925799925129 3721.355271714184 3874.3635541700774 4869.00400518422 4170.32406282556 4857.131808463394 4303.740718568124 2707.956047379447 4030.1624863041743 1.1697374045224176 1.0857938891535943 0.9233759890229192 0.9613417740193967 1.208140868198418 1.0347781452975409 1.2051950324508094 1.067882680461063 0.6719223000516674 1.0 11.976622290526892 -8.167480215747531 8.904863231776078 0.8368117547026727 1.0801090492166834 0.41840448381859785 0.11607124341772117 0.309837265336608 26.69127762030003 0.07793431359277381 0.029324974053316556 6.800170224220563e-09 8.167480215747531 0.24329729451401072 HLTGEFEK ddPTM_A459_Selumetinib_30min_R2 3 HLTGEFEK 8 0 F5H018;B5MDF5;J3KQE5;P62826;H0YFC6 F5H018 RAN GTP-binding nuclear protein Ran 0 ;; 163.15 0.00048524 22708800.0 177798.0 138490.0 205268.0 238201.0 264512.0 174507.0 185138.0 197503.0 184194.0 205004.0 False True 167916.69894178686 149111.7376844639 192061.2803589002 205757.61288035536 231281.63779271703 198543.75523317663 193747.28384398742 198077.701031618 221037.946810366 199085.00185564108 0.8434422351089274 0.7489852891710377 0.9647199867831637 1.0335163923074058 1.1617230611898235 0.9972813289930453 0.973188748715867 0.9949403480190161 1.1102692053650696 1.0 17.603025013609177 -5.431813107090135 3.560765269488287 1.037835718553777 0.7972504003830295 0.7232378387781897 0.059051636541294195 0.12418522099723284 2.9138006037140323 0.01667596780175992 0.03743684479481496 3.699873647152606e-06 5.431813107090135 -0.24058531817074746 HLTVEELFGT(ph)SLPK ddPTM_A459_Selumetinib_30min_R1 1 HLTVEELFGTSLPK 14 0 Q9NPI6-2;Q9NPI6;A0A087WT55 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 HLTVEELFGT(0.792)S(0.208)LPK 170.42 0.00021644 6917500.0 6646.1 7606.1 5985.7 5919.5 6064.3 6776.9 6837.4 5653.0 2809.0 5569.5 True False 6800.941198940582 6715.574276020045 5172.874817096577 4885.770447776952 5515.785135739124 6708.730538932877 6321.64941317768 5503.064076468132 4766.667838757275 6284.399576524088 1.0821942679052552 1.0686103253374668 0.8231295216205369 0.7774442710530638 0.877694848740015 1.0675213212084593 1.0059273501310677 0.8756706204718901 0.7584921647190561 1.0 12.617559198066765 -5.241987696717289 22.52447562433082 0.8986392519194406 1.0754025298840852 0.35462158844368186 0.09560101007600369 276.47287449974107 320141.50827023014 0.02666361067579043 0.07019590583524116 5.728122581579942e-06 5.241987696717289 0.17676327796464464 HLTVEELFGTS(ph)LPK ddPTM_A459_Selumetinib_30min_R1 1 HLTVEELFGTSLPK 14 0 Q9NPI6-2;Q9NPI6;A0A087WT55 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 HLTVEELFGT(0.081)S(0.919)LPK 167.92 0.00013607 7875300.0 7460.9 7901.2 7081.3 6319.9 7131.6 6758.2 7446.0 6967.3 3326.1 6303.9 True False 7634.724453615772 6976.123830831771 6119.698354796601 5216.24810421582 6486.548039186244 6690.21864395464 6884.342225191008 6782.50457102006 5644.148771267561 7113.066970185869 1.0733379125511413 0.9807476662418491 0.860345949285599 0.733333191727213 0.9119200010873434 0.9405533045023223 0.9678444268901796 0.9535274445536156 0.7934901772926898 1.0 12.79625603137485 -4.977755890358575 3.2946952126053324 0.893032887023195 1.0698435966580928 0.3455824678631676 0.07754585681610866 0.2971806222053485 6.350772890003252 0.021114994492942914 0.10535912729579357 1.0525533301503207e-05 4.977755890358575 0.17681070963489776 HLTYENVER ddPTM_A459_Selumetinib_30min_R2 1 HLTYENVER 9 0 H3BMH2;H3BSC1;P62491-2;Q15907-2;P62491;Q15907 H3BMH2 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 94.409 0.043074 0.0 16934.0 15629.0 16526.0 18432.0 18578.0 12587.0 11694.0 16989.0 11784.0 16453.0 False True 15992.876072173018 16827.694044844317 15462.735152148323 15921.529803026488 16244.065550572748 14320.744996590356 12237.794171221409 17038.435177319636 14141.1292724701 15977.959139972168 1.0009335943389372 1.053181692194115 0.9677540802733119 0.9964683013361505 1.016654593259965 0.896281237868737 0.7659172278520876 1.066371182205271 0.885039769384135 1.0 13.963795524569216 -6.7571804706692316 24.972310788938326 0.9170697874556196 1.006798947492204 0.23466877175085343 0.07575462593134773 155.90778997458594 914172.8742649964 0.025335757625410432 0.024494213765372582 1.749119692517581e-07 6.7571804706692316 0.08972916003658449 HLYISS(ph)SNPDLITR ddPTM_A459_Selumetinib_30min_R2 1 HLYISSSNPDLITR 14 0 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 HLYISS(0.622)S(0.378)NPDLITR 131.48 0.00058601 9510300.0 23974.0 28751.0 34601.0 33537.0 35762.0 25501.0 23847.0 29549.0 24006.0 28578.0 True False 22641.62105552593 30956.109250964153 32374.80933072033 28969.202745448092 31269.257843663607 29013.531274970268 24955.932751934062 29634.9826978997 28807.870783682734 27752.878885438815 0.8158296351520266 1.1154197508210937 1.1665387747469513 1.043826943685019 1.126703214204914 1.0454242024668974 0.8992196036652531 1.0678165252776126 1.0380137823754725 1.0 14.760349813654312 -7.01393276979655 24.623814711191947 1.001972149270979 1.065143395900509 0.05586146170521045 0.09767627375692098 1489.251245306996 2631998.278365339 0.03647210306686998 0.02947947324557172 9.684277604366411e-08 7.01393276979655 0.06317124662953 HLYISSS(ph)NPDLITR ddPTM_A459_Selumetinib_30min_R1 2 HLYISSSNPDLITR 14 0 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 HLYISS(0.069)S(0.931)NPDLITR;HLYISS(0.005)S(0.995)NPDLITR 197.51 6.8966e-05 26619000.0 5740.5 6238.3 6309.1 6498.9 7263.7 5053.5 6391.4 5745.6 2641.3999999999996 4783.3 True False 5874.242480931438 5507.9169358930085 5452.358873405624 5363.989114461968 6606.699617510397 5002.66637821088 5909.29155225434 5593.208023660939 4482.262879776956 5397.283148287579 1.0883702632490544 1.0204980514391822 1.0102043423709426 0.993831334597264 1.224078751474533 0.9268860352079359 1.0948640991957608 1.0363006479353454 0.8304665063197701 1.0 12.398017659561116 -8.140174774289019 7.514131525678749 0.9162736854830402 1.0492700127795418 0.2954259826717891 0.08305376607026593 0.30344590995356124 17.030420245564358 0.05356865913149935 0.020048327210688045 7.241444820295762e-09 8.140174774289019 0.13299632729650157 HLYISSS(ph)NPDLITR ddPTM_A459_Selumetinib_30min_R2 3 HLYISSSNPDLITR 14 0 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 HLYISS(0.138)S(0.862)NPDLITR;HLYISS(0.028)S(0.972)NPDLITR;HLYISS(0.188)S(0.809)NPDLIT(0.003)R 175.26 4.6796e-05 16139000.0 63327.0 50660.0 62904.0 70660.0 89170.0 64214.0 56686.0 61342.0 54623.0 70760.0 True False 59807.53885806664 54545.45910242578 58856.82512469671 61035.98610470112 77967.66741008565 73058.89562334574 59322.011321178106 61520.49506428522 65549.12629413902 68716.97494344061 0.8703459211831265 0.793769794833386 0.8565107118458057 0.8882228322032287 1.1346201935440126 1.063185561987833 0.8632803083954833 0.8952736222006477 0.9539000566903741 1.0 16.06837890714695 -6.012696037144247 23.498626658111586 0.9806982671020026 0.8416984817109744 0.4397100469057985 0.07483875880224328 295.3376975988386 546633.386639376 0.024363964084779994 0.03314494063183345 9.711894652647144e-07 6.012696037144247 -0.1389997853910282 HLYTLDGGDIINALCFSPNR ddPTM_A459_Selumetinib_30min_R1 1 HLYTLDGGDIINALCFSPNR 20 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6REE5;D6RAC2;D6R9L0;D6R9Z1;H0Y8R5;D6RF23 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 110.26 0.0005337 10513000.0 2201.4 2336.0 2409.4 2371.7 2451.5 2158.6 2183.3 2054.5 1270.5 1874.8 False True 2252.688336821265 2062.5000340230636 2082.216713886846 1957.5271173228477 2229.7622578474775 2136.886443851986 2018.6119232150854 2000.0079860434766 2155.9457063514133 2115.4488420984576 1.0648748823378162 0.9749704143056135 0.9842907436236338 0.9253483602945668 1.054037428593936 1.0101338313302168 0.954223937276917 0.9454296158065125 1.019143390966044 1.0 11.04674808208253 -7.245954084701988 24.596179199454316 0.9751517014499734 0.9990733597429319 0.057822572528656524 0.04193108338247601 2020.9109931758726 3209935.162674255 0.016300157062306444 0.01258687728938166 5.6760461159871346e-08 7.245954084701988 0.023921658292958448 HMAVQRRLDVMEEMVEK ddPTM_A459_Selumetinib_30min_R1 1 HMAVQRRLDVMEEMVEK 17 2 Q5JTB6 Q5JTB6 PLAC9 Placenta-specific protein 9 0 46.89 0.045656 0.0 380.43 400.14 635.02 682.64 568.21 435.83 276.11 470.07 235.55 356.49 False True 389.2932788120802 353.2914227799606 548.7877719151761 563.4297387398356 516.8155058256232 431.44594590197846 255.2828004025636 457.6022165974484 399.711146108678 402.2489640066565 0.9677918743021003 0.8782904479378952 1.3642987826466961 1.40069904252261 1.284815007794702 1.0725843557295993 0.6346388014521751 1.1376094348123067 0.9936909274477672 1.0 8.651944895063076 -7.003146079026787 24.7730091566022 0.9387607249082093 1.1844186871701075 0.25379773994659816 0.19200355900178803 174.0483812956376 1370510.0146844278 0.07454078023517853 0.06446094296032605 9.927820606863094e-08 7.003146079026787 0.24565796226189818 HMDLLT(ph)GY(ph)S(ph)KLIQS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 HMDLLTGYSKLIQSR 15 1 A0A0G2JNJ9;Q9UFV3 A0A0G2JNJ9 Putative uncharacterized protein DKFZp434L187 4 HMDLLT(1)GY(1)S(1)KLIQS(1)R 53.536 0.045581 0.0 3638.1 3776.3 3602.0 6509.8 5943.2 3787.1 3761.3 3873.8 3363.6 2951.5 True False 3435.9089664682106 4065.930067281695 3370.2512415610736 5623.154009968633 5196.562083117874 4308.738649129053 3936.2079028745547 3885.0721166578887 4036.4139868364255 2866.282526082045 1.1987335286046608 1.4185377855404442 1.1758266014927388 1.9618282422615845 1.812997161246737 1.5032498052516539 1.373279803039864 1.3554393474143804 1.408240098492261 1.0 11.4849651060167 -8.856098479953166 0.824494713141411 1.0022872813262644 1.5086000481208006 0.27901636429399146 0.23198192022789785 1.6690279109055248 2.103209431860114 0.2513550847981124 0.08612895120441376 1.3928409286521838e-09 8.856098479953166 0.5063127667945362 HMDPPPAPVQDRS(ph)PS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 HMDPPPAPVQDRSPSPR 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 HMDPPPAPVQDRS(1)PS(1)PR;HMDPPPAPVQDRS(1)PS(1)PR 81.574 0.011725 10137500.0 39417.0 29561.0 30833.0 29937.0 37811.0 26159.0 28707.0 30907.0 27006.0 37402.0 True False 37226.360938753016 31828.23364640365 28849.23834843212 25859.528955794478 33060.84414537118 29762.164802240983 30041.93238184136 30996.9342530707 32407.95461068632 36322.107077933455 1.0248954131124435 0.876277182326244 0.7942611447769978 0.7119501327472479 0.9102127273187967 0.8193953268840565 0.8270977318959711 0.853390310935515 0.8922377366806158 1.0 15.148560276636175 -8.689773350808501 1.9777567380494019 0.9998305541902123 0.8460725988477396 0.25039322023215194 0.07667453811874428 0.9068570898284846 6.840929589472928 0.07592146211123244 0.02110242130111162 2.0428037630177412e-09 8.689773350808501 -0.15375795534247272 HMDPPPAPVQDRS(ph)PSPR ddPTM_A459_Selumetinib_30min_R1 6 HMDPPPAPVQDRSPSPR 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HMDPPPAPVQDRS(0.5)PS(0.5)PR;HMDPPPAPVQDRS(0.66)PS(0.34)PR;HMDPPPAPVQDRS(0.963)PS(0.037)PR;HMDPPPAPVQDRS(0.649)PS(0.351)PR;HMDPPPAPVQDRS(0.816)PS(0.184)PR;HMDPPPAPVQDRS(0.716)PS(0.284)PR 135.55 0.00034996 82059600.0 14933.77 16084.51 18578.56 19409.22 16223.27 15567.95 15679.910000000002 13873.670000000002 9656.34 12410.63 True False 15281.69778494198 14201.328091714164 16055.69359672516 16019.764083182927 14755.87809295096 15411.350557567643 14497.161764732029 13505.695203568663 16386.103708830717 14003.655250273307 1.091264924180687 1.0141158031890996 1.1465359086451234 1.1439701847037596 1.0537161783287239 1.100523419217055 1.0352412642012943 0.9644407093858637 1.1701304706505762 1.0 13.773515829801594 -7.264904920604924 24.110200982227212 1.0394898325015534 1.0913053341193928 0.1334076289365329 0.061283758836270054 385.6313973499959 2682867.8666631286 0.02454631705963724 0.017317661864758385 5.433692774369326e-08 7.264904920604924 0.05181550161783943 HMDPPPAPVQDRS(ph)PSPR ddPTM_A459_Selumetinib_30min_R2 7 HMDPPPAPVQDRSPSPR 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HMDPPPAPVQDRS(0.621)PS(0.379)PR;HMDPPPAPVQDRS(0.96)PS(0.04)PR;HMDPPPAPVQDRS(0.909)PS(0.091)PR;HMDPPPAPVQDRS(0.795)PS(0.205)PR;HMDPPPAPVQDRS(0.739)PS(0.261)PR;HMDPPPAPVQDRS(0.769)PS(0.231)PR;HMDPPPAPVQDRS(0.734)PS(0.266)PR 119.62 0.003066 122360200.0 205394.0 200587.0 231562.0 238356.0 257610.0 193815.0 179339.0 185348.0 162315.7 250239.0 True False 193979.02373732754 215971.37791113852 216663.55302564215 205891.5016129658 225246.7287373798 220511.2569726034 187678.61885348667 185887.33199398674 194783.37547958884 243013.94987099603 0.7982217639781639 0.8887200838708517 0.8915683776205358 0.847241492606755 0.9268880607757375 0.9074016413035623 0.7722956602002308 0.7649245324915094 0.8015316634415004 1.0 17.8906796065068 -7.253513482224336 24.907967440185672 0.8150983410840814 0.8788428305837088 0.05103068387962206 0.07043011574496 1045.3923309857043 3285263.8284834777 0.02609941255864842 0.019844209396555335 5.5781028522733166e-08 7.253513482224336 0.06374448949962741 HMDPPPAPVQDRSPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 HMDPPPAPVQDRSPSPR 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HMDPPPAPVQDRS(0.358)PS(0.642)PR 147.28 0.00021688 16433000.0 3522.0 4185.0 5044.1 5581.0 4676.4 3447.9 4168.4 3602.7 2254.0 3146.4 True False 3604.0557473809795 3695.018254446285 4359.1389252580075 4606.383118344986 4253.420445685477 3413.2172564427215 3853.9742320019072 3507.14469278113 3824.873374353473 3550.2710885313563 1.0151494512696133 1.0407707361791367 1.2278326968719608 1.2974736304574737 1.198055117375556 0.9613962346336403 1.0855436488925088 0.9878526471148809 1.0773468501346786 1.0 11.793713473546417 -6.754302908615302 24.999957722873145 1.0256133991703296 1.1613290080751233 0.37872515329228984 0.08525458590931849 200.69760053134334 703068.2720045978 0.0315614680842899 0.03093900232054177 1.760747544408733e-07 6.754302908615302 0.13571560890479373 HMLDS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 HMLDSPQK 8 0 A0A3B3IRS8;B1AL16;Q8IX21;Q8IX21-2 A0A3B3IRS8 FAM178A Protein FAM178A 1 HMLDS(1)PQK;HMLDS(1)PQK 129.16 0.002743 8023600.0 76385.0 75562.0 82104.0 81825.0 83919.0 61794.0 70056.0 77500.0 53812.0 79382.0 True False 72139.82749338231 81357.36242987555 76821.51802807603 70680.29384400178 73376.34497462133 70305.5625899186 73313.7428133304 77725.51216918428 64575.90363290574 77090.03540079431 0.9357866696820716 1.0553551053245107 0.9965168342273778 0.9168538252256855 0.9518265829446653 0.9119928694337348 0.9510145174038278 1.0082433062209155 0.837668620816853 1.0 16.234256770079824 -5.699346353236076 7.728906388741316 0.9398798538430173 1.002422350669676 0.19125164684937512 0.052513420037184254 0.35479157455408095 37.954587105676 0.013462195384961377 0.023317925521154647 1.998267600001921e-06 5.699346353236076 0.0625424968266588 HMQLYCDR ddPTM_A459_Selumetinib_30min_R2 1 HMQLYCDR 8 0 B1AHB2;B1AHB1;P33992 B1AHB2 MCM5 DNA helicase;DNA replication licensing factor MCM5 0 107.69 0.018536 5043500.0 13637.0 12866.0 15932.0 18461.0 17607.0 14124.0 17759.0 11859.0 16106.0 13128.0 False True 12879.110133236305 13852.780829289586 14906.952465450018 15946.579952998703 15395.051251422881 16069.452795093535 18584.828688790916 11893.50772663687 19327.650039239947 12748.960529359678 1.0102086443500162 1.0865811998858976 1.1692680694336361 1.2508141284362129 1.2075534484532682 1.2604519998385022 1.457752468994768 0.9329001920781872 1.5160177172664513 1.0 13.638092003082846 -5.179986792462176 1.4437846440028763 1.2404904340101361 0.9920147875724826 0.16476224942547657 0.1666714172888898 1.0649075822103837 3.2923500180927143 0.046499060885501146 0.3082351948771522 6.607135409785102e-06 5.179986792462176 -0.24847564643765352 HNDDEQYAWES(ph)SAGGSFTVR ddPTM_A459_Selumetinib_30min_R1 1 HNDDEQYAWESSAGGSFTVR 20 0 P07900;P07900-2;Q14568;P08238 P07900;P08238 HSP90AA1;HSP90AA2P;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta 1 HNDDEQYAWES(0.379)S(0.379)AGGS(0.232)FT(0.01)VR 115.81 0.00017823 3952900.0 586.06 1127.8 992.73 978.4 1175.0 988.87 918.75 911.46 244.52 718.42 True False 599.7140577257514 995.756651700005 857.9227186755581 807.540806842633 1068.7214574630996 978.9228656221221 849.4479478101313 887.2851199606654 414.9325809657988 810.6362050033997 0.7398066531252898 1.2283643952169998 1.0583325952878704 0.9961815199695482 1.3183737055743983 1.2075982537913128 1.0478781265469987 1.0945540237213365 0.5118604108782171 1.0 9.662910800901424 -8.226080127453624 22.465053350342046 0.7559304949207567 1.0976667409978458 0.3385239136624033 0.18423283872221322 158.8883204336383 100948.01709607789 0.11832011745287081 0.04471228978265992 5.941825216600905e-09 8.226080127453624 0.3417362460770891 HNDDEQYAWESSAGGSFTVR ddPTM_A459_Selumetinib_30min_R1 1 HNDDEQYAWESSAGGSFTVR 20 0 P07900;P07900-2;Q14568;P08238 P07900;P08238 HSP90AA1;HSP90AA2P;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta 0 113.11 0.011343 0.0 192.31 208.53 232.91 170.55 413.09 223.87 290.6 274.72 222.42 225.29 False True 196.7904488298797 184.11521065703315 201.28210128305196 140.7666441200032 375.7260824369632 221.61807105769662 268.67980803659793 267.43353318367684 377.43049508593595 254.20816601043407 0.7741311064798853 0.7242694581631813 0.7918002967488867 0.5537455634459256 1.4780252276456824 0.8717976079832157 1.056928312938499 1.052025736941511 1.4847300187455197 1.0 7.989866565017406 -6.246291957684811 24.999818645792892 1.140563632655557 0.7177077827521339 0.5595596442152346 0.1935866871064051 640.5480803045622 1057182.0503781794 0.05585787857197105 0.07183901921058022 5.671631975569412e-07 6.246291957684811 -0.4228558499034232 HNDLDDVGK ddPTM_A459_Selumetinib_30min_R2 2 HNDLDDVGK 9 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 ; 112.36 0.013686000000000002 8399200.0 150743.0 101069.0 120372.0 151121.0 154451.0 125502.0 178697.0 174534.0 145730.0 99481.0 False True 142365.30753204078 108820.66731194395 112627.3965711242 130538.05910173427 135047.484570541 142788.76130627486 187006.7645813881 175041.86504434087 174880.0720364108 96608.72504732103 1.4736278474051614 1.1264062046015124 1.1658097808035133 1.3512036209751648 1.397880828096964 1.4780110309533 1.9357129957960646 1.8118639383616915 1.8101892137666735 1.0 16.559865868963207 -6.8222809799679744 2.1802028653162213 1.7046154186278277 1.2712470763302979 0.25435821244984214 0.2587836645298689 0.3335734297696222 3.2524693955295745 0.09944299952017716 0.08802661017946763 1.505632636369072e-07 6.8222809799679744 -0.43336834229752985 HNGPNDASDGTVR ddPTM_A459_Selumetinib_30min_R1 2 HNGPNDASDGTVR 13 0 P31942;P31942-2 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 ; 205.87 1.8333e-05 2450000.0 1228.3 1870.29 1855.23 1839.3899999999999 1783.99 1546.1 1514.07 1723.13 723.08 1530.92 False True 1256.9170001442533 1651.3155773257674 1603.2999560489318 1518.1750661266053 1622.628419489017 1530.5476377464804 1399.862480915249 1677.4269948849337 1227.0139483263133 1727.4284944236035 0.727623171784979 0.9559386004436421 0.9281425895338782 0.8788642024995539 0.939331743529242 0.8860266243652436 0.8103736191884142 0.9710543737699812 0.710312439726042 1.0 10.754410277257929 HNGS(ph)LSPGLEAR ddPTM_A459_Selumetinib_30min_R1 1 HNGSLSPGLEAR 12 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 HNGS(0.761)LS(0.239)PGLEAR 120.29 0.0040688 105200000.0 2851.0 2869.9 2258.8 2784.3 3057.8 2611.0 2830.5 2860.7 1045.9 2036.0 True False 2917.422752919696 2533.8907738196854 1952.0673667002607 2298.0742727840816 2781.2225298984367 2584.735710598321 2616.9931061513776 2784.8249431368104 1774.815910486379 2297.340432319427 1.2699131186117791 1.1029670388299544 0.8497074875095575 1.000319430439795 1.2106270758881286 1.1250991251604516 1.1391403160519946 1.2121951557371984 0.7725524199713406 1.0 11.165748943566564 -8.260362126836231 24.999955709351603 0.8862762103516801 1.1052588905726894 0.3489575768169453 0.12384696663354623 114.76745063592513 2663600.0449543083 0.10067570052657263 0.03306898719251786 5.490828423558579e-09 8.260362126836231 0.2189826802210093 HNGS(ph)SEILNK ddPTM_A459_Selumetinib_30min_R1 1 HNGSSEILNK 10 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2 Q8TDM6-4 DLG5 Disks large homolog 5 1 HNGS(0.791)S(0.209)EILNK 124.38 0.0038605 14920000.0 3014.4 3065.4 3147.5 3587.0 3789.6 2907.7 3483.3 3498.0 1363.0 2897.6 True False 3084.629654998644 2706.501542934204 2720.0867879799316 2960.5977863292374 3446.831349108219 2878.451177980365 3220.5518765790803 3405.2216768946632 2312.911450418716 3269.535185014133 0.9434459274630227 0.8277939798107739 0.8319490796267953 0.9055103000264669 1.0542267184970882 0.8803854416902147 0.9850182653914945 1.04150023908672 0.7074129255497577 1.0 11.674869833553675 -6.000950952547564 24.81625180554437 0.948739622360509 0.8645683390791613 0.11114455877586593 0.0975831634390466 66.22232327415472 1728291.7429890072 0.026641187268803563 0.038951538323760915 9.97812746372779e-07 6.000950952547564 -0.08417128328134771 HNGS(ph)SEILNK ddPTM_A459_Selumetinib_30min_R2 4 HNGSSEILNK 10 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2 Q8TDM6-4 DLG5 Disks large homolog 5 1 HNGS(0.983)S(0.017)EILNK;HNGS(0.696)S(0.304)EILNK;HNGS(0.5)S(0.5)EILNK;HNGS(0.5)S(0.5)EILNK 117.93 0.0058695 25919400.0 186777.0 173164.0 194952.0 206212.0 209355.0 156246.0 173887.0 175972.0 138623.0 186040.0 True False 176396.68206757176 186445.12198998124 182409.00056768808 178125.5698644582 183053.95324255349 177767.46824002996 181973.09005055382 176484.04938626697 166351.4734502395 180668.5418100302 0.9763552652849203 1.0319733591807312 1.0096334355733492 0.9859246556146676 1.0132032472760615 0.9839425638745085 1.0072206717752519 0.9768388432106617 0.9207550566559348 1.0 17.46298579898111 -7.958194288383146 5.0520007501617314 0.9566508395707192 1.001607642293082 0.3322744450066538 0.02352229777527467 0.1768791468277477 10.502905521054107 0.013028869345331297 0.005833419268279994 1.1010466290314854e-08 7.958194288383146 0.0449568027223628 HNGSLS(ph)PGLEAR ddPTM_A459_Selumetinib_30min_R1 3 HNGSLSPGLEAR 12 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 HNGS(0.228)LS(0.772)PGLEAR;HNGS(0.002)LS(0.998)PGLEAR;HNGS(0.01)LS(0.99)PGLEAR 158.31 0.00045283 122805600.0 7608.2 9029.3 8038.3 8459.3 9195.0 7582.5 9640.2 8208.7 3676.0000000000005 6778.599999999999 True False 7785.456257019868 7972.145358392312 6946.743011221314 6982.0420557276075 8363.313873509098 7506.226934359153 8913.031952630456 7990.978610384569 6237.903515582684 7648.699339155432 1.0178797612248067 1.0422877151911418 0.9082253992727045 0.9128404381101693 1.0934295496092246 0.9813729892523124 1.16530034158914 1.0447499968363159 0.8155508850569451 1.0 12.900998723122672 HNGSLS(ph)PGLEAR ddPTM_A459_Selumetinib_30min_R2 6 HNGSLSPGLEAR 12 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 HNGSLS(1)PGLEAR;HNGSLS(1)PGLEAR;HNGS(0.001)LS(0.999)PGLEAR;HNGS(0.01)LS(0.99)PGLEAR;HNGS(0.007)LS(0.993)PGLEAR;HNGS(0.007)LS(0.993)PGLEAR 125.39 0.0019076 272264500.0 159396.0 142828.0 175631.0 200917.0 215241.0 128717.0 148939.0 150650.0 135098.0 162709.0 True False 150537.40843274433 153782.4483355953 164331.09267257457 173551.75799884283 188200.50130104553 146446.59837341093 155864.95861702965 151088.36655855007 162121.37495351044 158011.1684012477 0.9527010650948116 0.9732378406638059 1.0399966934949705 1.0983512099482229 1.1910582220564065 0.926811692206021 0.9864173538748346 0.9561878953700403 1.0260121268252724 1.0 17.269667007697755 HNGVGGS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 HNGVGGSPPK 10 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 HNGVGGS(1)PPK;HNGVGGS(1)PPK 91.093 0.028516000000000007 37117000.0 11508.2 13089.400000000001 12743.099999999999 13440.2 12049.7 12019.6 10830.2 11728.2 8796.599999999999 11293.400000000001 True False 11776.31866894088 11556.886962903027 11012.657012837837 11093.121373800444 10959.806762547327 11898.69373692361 10013.26929455596 11417.130037437382 14927.187721755885 12743.017897031534 0.9241389099582255 0.906919150258369 0.864211060662735 0.870525448793772 0.8600636718167364 0.9337422134277463 0.7857847627200253 0.895951816884522 1.17140129931334 1.0 13.637419367463787 -8.187766070537837 7.22545927121053 1.0845965478834068 0.8775194238255126 0.6922715548704474 0.05483387361519245 0.12299854373526341 10.413483459738265 0.035463742017141225 0.013184498826537362 6.489839097290852e-09 8.187766070537837 -0.20707712405789414 HNGVGGS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 HNGVGGSPPK 10 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 HNGVGGS(1)PPK 77.64399999999998 0.036047 12654000.0 81415.0 72433.0 69454.0 60503.0 51185.0 49611.0 71405.0 83006.0 60192.0 70329.0 True False 76890.28023006776 77988.3781911963 64985.40525579759 52262.387026503435 44754.682700294215 56444.46492618135 74725.47398632321 83247.5337176169 72232.08190500009 68298.41903331317 1.125798829875752 1.141876771015106 0.9514920868680777 0.7652063952023835 0.6552813862128304 0.8264388213532446 1.0941025435724243 1.2188793664024955 1.0575952258831678 1.0 16.059564563054607 -7.32488363659397 7.521911181106406 1.112129941404017 0.9052504379569223 0.2586008085148789 0.1490884337246266 0.44083071950611596 46.60363999379923 0.07254513370573816 0.048814397797565544 4.7327805050724766e-08 7.32488363659397 -0.20687950344709483 HNLDVVS(ph)PIPANK ddPTM_A459_Selumetinib_30min_R2 1 HNLDVVSPIPANK 13 0 Q13017-2;Q13017;A0A0A0MSK6 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 HNLDVVS(1)PIPANK 68.329 0.044465 3139600.0 44761.0 39770.0 52999.0 44650.0 52359.0 46287.0 53588.0 50737.0 41210.0 50152.0 True False 42273.36281248004 42820.231119294804 49589.10204094816 38568.59297445383 45781.19432460103 52662.614098449056 56079.948182607506 50884.63627003747 49453.15150360601 48703.98144945507 0.8679652372229831 0.8791936479306849 1.018173475045601 0.7918981534287965 0.9399887434688003 1.0812794463857591 1.1514448411329001 1.0447736459255488 1.0153821111099188 1.0 15.571752094004854 -6.6636425986042855 4.550630248116132 1.0670005502076587 0.8946162629819583 0.6049756357740472 0.0649049046983424 0.14608225720814041 5.268337485528328 0.022135666713526 0.021911313946337774 2.169488744914246e-07 6.6636425986042855 -0.17238428722570043 HNPT(ph)GAVLFMGQINKP ddPTM_A459_Selumetinib_30min_R2 1 HNPTGAVLFMGQINKP 16 1 P07093-2;P07093;P07093-3 P07093-2 SERPINE2 Glia-derived nexin 1 HNPT(1)GAVLFMGQINKP 108.71 0.0090803 6697000.0 44004.0 51184.0 50956.0 57196.0 46254.0 30958.0 25678.0 25017.0 18963.0 42743.0 True False 41558.43384196893 55109.648217500246 47677.546436697914 49405.80613139664 40443.159003993525 35222.18349125643 26872.077879991703 25089.79532821271 22756.129870489716 41508.89853034889 1.001193366082307 1.3276586507639387 1.1486102528555142 1.1902461371089863 0.97432503477354 0.8485453658931476 0.6473811358869088 0.604443775106885 0.548222927521234 1.0 15.341133029007546 -6.720987605668373 1.609778336203779 0.6676844918898326 1.1805120117938628 0.6926190186771902 0.13847443433734333 0.18722288503130183 1.0062336471397542 0.056397835791707 0.0529663921230377 1.9011325355766902e-07 6.720987605668373 0.5128275199040302 HNS(ph)FDTVNTALVEDSEGLDCAGQHCSR ddPTM_A459_Selumetinib_30min_R1 1 HNSFDTVNTALVEDSEGLDCAGQHCSR 27 0 A6QL63-2;A6QL63-3;A6QL63 A6QL63-2 BTBD11 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 1 HNS(0.649)FDT(0.233)VNT(0.118)ALVEDSEGLDCAGQHCSR 65.881 0.00063694 2786500.0 364.48 427.61 378.76 479.7 808.36 303.05 638.17 318.59 125.01 273.55 True False 372.97167484537766 377.5452224095043 327.32647237975533 395.92940008423034 735.2439807275492 300.00159214738443 590.0323231063853 310.1399582738336 212.13283963084635 308.6628071026422 1.2083466691254132 1.223163963139738 1.0604661943313007 1.2827246787546018 2.382029722431224 0.9719395574848848 1.911575705038466 1.0047856467873701 0.6872640135107178 1.0 8.269887842986087 -7.982758676860647 24.38878215658705 0.8444294699216284 1.4270510351512815 0.27422652049259055 0.4058810363932715 219.998011108487 311198.7339814339 0.22189816816841182 0.10655436376442501 1.0404981757893152e-08 7.982758676860647 0.5826215652296531 HNS(ph)GSSSVDDGSATR ddPTM_A459_Selumetinib_30min_R2 2 HNSGSSSVDDGSATR 15 0 Q9NV58-3;Q9NV58 Q9NV58-3 RNF19A E3 ubiquitin-protein ligase RNF19A 1 HNS(1)GSSSVDDGSATR;HNS(0.771)GS(0.203)S(0.021)S(0.006)VDDGSATR 219.03 2.6075e-09 7857300.0 6987.7 3557.71 8050.7 8314.7 11920.7 7481.3 9179.9 8726.4 8279.7 9949.7 True False 6599.351607979413 3830.5749171593206 7532.726726939395 7182.223516342468 10423.115093589864 8511.781166520335 9606.783539626758 8751.792379266706 9935.87135414721 9662.42630857479 0.6829911450008066 0.39644027233200513 0.779589565433951 0.7433147003634792 1.078726477255512 0.8809155065914107 0.9942413254009863 0.9057551488387597 1.0282998324478558 1.0 13.238169790888797 -5.769190911784498 1.6340913197759819 0.9706674045918412 0.546747456719091 0.7273162286344133 0.1019831625179927 0.17851988929157023 0.9679916390423176 0.03014917730253496 0.06502743577535351 1.7014104199038751e-06 5.769190911784498 -0.4239199478727502 HNS(ph)MEDAR ddPTM_A459_Selumetinib_30min_R2 1 HNSMEDAR 8 0 Q96RY7-2;Q96RY7 Q96RY7-2 IFT140 Intraflagellar transport protein 140 homolog 1 HNS(1)MEDAR 83.397 0.025935000000000003 0.0 3971.2 2529.1 2541.2 2778.8 3146.7 1921.6 4285.9 11597.0 3031.3 6690.5 True False 3750.496601973162 2723.0738376617655 2377.7019586493593 2400.3226463026276 2751.3834141450766 2186.282957451977 4485.202842349733 11630.745350013298 3637.6447015986632 6497.327880993364 0.5772367765130788 0.419106729341392 0.36595074193575056 0.3694322789718359 0.42346383998777404 0.3364895534743616 0.6903149917168717 1.7900813323638358 0.559867805385021 1.0 12.665630795810303 -7.532248572981811 24.9120647616874 1.1530245654125961 0.41999153764549446 0.5452853982353749 0.2860560987678589 130.8671110848995 347938.017592116 0.1228306654698799 0.07103538264222663 2.9359687385970473e-08 7.532248572981811 -0.7330330277671017 HNS(ph)PSGHLTHSR ddPTM_A459_Selumetinib_30min_R2 1 HNSPSGHLTHSR 12 0 A0A087WVA8;Q8IWB9;Q8IWB9-2;J3KRZ8 A0A087WVA8 TEX2 Testis-expressed sequence 2 protein 1 HNS(0.998)PS(0.002)GHLTHSR 67.102 0.038209 396740.0 0.0 0.0 0.0 626.09 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 540.8154619345083 0.0 0.0 0.0 0.0 0.0 0.0 0.0 HNS(ph)SDGFFNNGPLR ddPTM_A459_Selumetinib_30min_R1 2 HNSSDGFFNNGPLR 14 0 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 HNS(0.965)S(0.035)DGFFNNGPLR;HNS(0.947)S(0.053)DGFFNNGPLR 141.18 0.00036802 11529300.0 3294.9 3583.2 3567.2 3411.1 3275.7 3193.1 3350.3 3679.6 1791.8400000000001 2482.0 True False 3371.6647592406575 3163.6772782155144 3082.7938332270105 2815.4154192772976 2979.413513371805 3160.980313102833 3097.584173657996 3582.0050549747275 3040.6216091843507 2800.5888767273173 1.203912786792427 1.1296471626040632 1.100766291991229 1.00529408035331 1.063852512637791 1.1286841633094886 1.106047445734962 1.279018525261212 1.0857079503713263 1.0 11.451514497621226 -7.560613168276618 24.999680294078996 1.1479244473683936 1.1012814628507135 0.0 0.08101954751239245 523.3854547610621 346746.52835293056 0.0378821686813284 0.02187135001841896 2.75034282840813e-08 7.560613168276618 -0.04664298451768012 HNS(ph)SDGFFNNGPLR ddPTM_A459_Selumetinib_30min_R2 2 HNSSDGFFNNGPLR 14 0 Q9HC44 Q9HC44 GPBP1L1 Vasculin-like protein 1 1 HNS(0.947)S(0.053)DGFFNNGPLR;HNS(0.83)S(0.17)DGFFNNGPLR 121.51 0.0012631 10148000.0 42939.0 31659.0 39462.0 37168.0 43934.0 29736.0 34570.0 38809.0 26906.0 34869.0 True False 40552.622278436145 34087.14350027038 36923.057882976966 32105.65428162373 38414.61814505667 33831.86408346796 36177.57349915546 38921.9277648242 32287.95181645287 33862.241369457835 1.1975764343530053 1.0066416788055677 1.0903902514935069 0.9481254926787432 1.134438140875839 0.9991029156735834 1.0683750406370307 1.149419713248219 0.9535089973570119 1.0 15.047389849108507 -4.752503706858527 24.96947075940967 1.04499556980894 1.1975767313759322 0.33228540490374336 0.06698285042633867 401.1922077185002 1120990.784408543 0.015473753908701886 0.1831579923529957 1.7680571266708136e-05 4.752503706858527 0.1525811615669923 HNS(ph)TTSSTSSGGYR ddPTM_A459_Selumetinib_30min_R1 5 HNSTTSSTSSGGYR 14 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0 A0A0A0MRT6 ABI1 Abl interactor 1 1 HNS(0.895)T(0.102)T(0.001)SST(0.001)SSGGYR;HNS(0.967)T(0.012)T(0.007)S(0.003)S(0.003)T(0.007)S(0.001)S(0.001)GGYR;HNS(0.994)T(0.004)T(0.001)SS(0.001)TSSGGYR;HNS(0.946)T(0.051)T(0.002)SSTSSGGYR;HNS(0.954)T(0.04)T(0.004)S(0.001)S(0.001)TSSGGYR 166.79 0.00022640000000000005 11992600.0 1354.9299999999998 1830.8 1546.77 1470.08 1157.61 1115.92 1505.02 1598.39 322.28 1280.07 True False 1386.4972327651644 1616.4490848841717 1336.7271297994348 1213.358124819316 1052.904379892645 1104.694857974292 1391.495129701447 1555.995504897559 546.8856216001054 1444.379453437685 0.959925890295131 1.119130489593267 0.9254681147796494 0.8400549605794181 0.7289666004225465 0.7648231601087034 0.9633861284786549 1.0772761279553118 0.3786301586459806 1.0 10.496234087606007 -5.551203705902125 3.3458439430305993 0.8251021707060698 1.039308090760203 0.18244633319350978 0.18414687459415907 0.3945023310302125 9.160152190676211 0.04999389978636974 0.10090356274453732 2.810582217098402e-06 5.551203705902125 0.2142059200541332 HNS(ph)TTSSTSSGGYR ddPTM_A459_Selumetinib_30min_R2 5 HNSTTSSTSSGGYR 14 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0 A0A0A0MRT6 ABI1 Abl interactor 1 1 HNS(0.878)T(0.11)T(0.004)S(0.001)S(0.003)T(0.003)SSGGYR;HNS(0.996)T(0.004)TSSTSSGGYR;HNS(0.497)T(0.497)T(0.005)SSTSSGGYR;HNS(0.824)T(0.132)T(0.044)SSTSSGGYR;HNS(0.41)T(0.148)T(0.239)S(0.02)S(0.086)T(0.086)S(0.008)S(0.003)GGYR 185.86 8.0918e-05 52225740.0 1853.6100000000001 1830.74 3571.27 7582.67 7906.0 3805.74 2825.4399999999996 4774.75 2883.4700000000003 4104.05 True False 1750.5937767887474 1971.151871243092 3341.498376304776 6549.89726516465 6912.777599463244 4329.946139931975 2956.8285585031454 4788.643731997586 3460.244570883349 3985.555412897513 0.43923458475165433 0.49457394692451595 0.8384021874320132 1.6434089070669453 1.7344577814908937 1.08640971994016 0.7418861995832898 1.2014997248567232 0.8681963270880076 1.0 11.960565071763085 -5.490686587990491 4.517975650561078 1.195765174222559 0.4935261357294517 0.4858185316028921 0.29401944384717155 0.18622088843280854 8.947279452713415 0.08843293640352064 0.1815861820548498 3.230824830631826e-06 5.490686587990491 -0.7022390384931073 HNS(ph)WDTVNTVLPEDPEVADLFSR ddPTM_A459_Selumetinib_30min_R1 2 HNSWDTVNTVLPEDPEVADLFSR 23 0 Q8N961 Q8N961 ABTB2 Ankyrin repeat and BTB/POZ domain-containing protein 2 1 HNS(0.986)WDT(0.014)VNTVLPEDPEVADLFSR;HNS(0.995)WDT(0.005)VNTVLPEDPEVADLFSR 165.42 2.719e-12 11561300.0 889.8199999999999 1216.31 1168.4299999999998 1414.63 1146.42 1170.9299999999998 1094.51 889.22 462.46000000000004 962.63 True False 910.5510747116816 1073.9038597528217 1009.7636237265741 1167.5914263939035 1042.7265134168897 1159.1515073193757 1011.9502295049438 865.6349970063665 784.7608432579888 1086.192937310241 0.8382958896478333 0.988686100659197 0.9296356006761284 1.074939254609067 0.9599827780127277 1.067169070524251 0.9316486921843317 0.7969440485867584 0.7224875216011863 1.0 10.085064672314488 -7.629775855340899 4.663046174778954 0.8211027637590775 0.9800716760780137 0.3038597047236645 0.09072345208998366 0.22013157318380344 8.04314240480676 0.04333621342835627 0.024102285799244283 2.345439012567466e-08 7.629775855340899 0.15896891231893617 HNS(ph)WSSSSR ddPTM_A459_Selumetinib_30min_R1 2 HNSWSSSSR 9 0 H3BQ37;H3BPW9;Q96F86 H3BQ37 EDC3 Enhancer of mRNA-decapping protein 3 1 HNS(0.993)WS(0.007)SSSR;HNS(0.75)WS(0.189)S(0.055)S(0.005)SR 137.4 0.0025568 7450200.0 1861.16 2030.3000000000002 2030.06 2109.08 2052.38 1689.1 1889.87 1881.06 1241.04 1827.62 True False 1904.5214068130558 1792.591532139138 1754.3890023213805 1740.7687703348956 1866.7425913771185 1672.109187580092 1747.3155843569334 1831.1681782559951 2105.9542380246817 2062.2128295263424 0.9235329057915396 0.8692563184910783 0.8507313004760696 0.8441266320386158 0.9052133536604365 0.8108325016890469 0.8473012869182198 0.8879627514860265 1.0212109089188364 1.0 11.009977517589883 -8.197226691329156 4.208049753857846 1.011931127852576 0.8632426433809076 0.7793939625623396 0.03061326647150007 0.09383556217577829 3.206330971761086 0.02405023791837351 0.007980457753154844 6.349993908412312e-09 8.197226691329156 -0.14868848447166838 HNS(ph)WSSSSR ddPTM_A459_Selumetinib_30min_R2 2 HNSWSSSSR 9 0 H3BQ37;H3BPW9;Q96F86 H3BQ37 EDC3 Enhancer of mRNA-decapping protein 3 1 HNS(0.976)WS(0.024)SSSR;HNS(0.975)WS(0.025)SSSR 137.4 0.0025568 77565000.0 11694.5 8976.4 25134.0 26288.0 37361.0 24543.0 17122.0 15943.199999999999 31350.0 24910.0 True False 11044.566506792688 9664.861016324809 23516.905803830094 22707.52905067058 32667.37716842223 27923.575470828422 17918.206926599356 15989.592072461146 37620.87599218752 24190.78357604732 0.45656092420786837 0.39952657944881703 0.972143201971991 0.938685139292247 1.3504059124718915 1.1543063656059969 0.7407038664237895 0.6609786748823364 1.5551739311759252 1.0 14.562169880697331 -5.300859903862208 4.289300442939212 1.0396926155425406 0.4202800620493638 0.496083209902181 0.24975850015967643 0.1699084217199901 7.124304512915646 0.06777460196936719 0.16044389953204113 5.001958637762048e-06 5.300859903862208 -0.6194125534931767 HNSFDT(ph)VNTALVEDSEGLDCAGQHCSR ddPTM_A459_Selumetinib_30min_R2 2 HNSFDTVNTALVEDSEGLDCAGQHCSR 27 0 A6QL63-2;A6QL63-3;A6QL63 A6QL63-2 BTBD11 Ankyrin repeat and BTB/POZ domain-containing protein BTBD11 1 HNS(0.391)FDT(0.597)VNT(0.012)ALVEDSEGLDCAGQHCSR;HNS(0.41)FDT(0.589)VNTALVEDSEGLDCAGQHCSR 106.1 1.7150000000000004e-09 9455800.0 11178.7 9913.9 18512.5 26533.0 33245.0 14896.099999999999 12730.3 14883.3 14575.8 24306.0 True False 10557.432605881688 10674.264251787195 17321.42590488599 22919.15962802202 29068.4658859291 16947.902561667564 13322.284174610899 14926.607938937055 17491.36728187965 23604.222625427785 0.44726881174678607 0.45221841960973047 0.733827424853483 0.9709770998063805 1.231494311302374 0.7180029959304968 0.564402581098324 0.6323702405203245 0.7410270424681122 1.0 14.526757349976725 -5.329210965025916 3.755599251767117 0.8231531711072752 0.4438194120407943 0.4025747243554969 0.1850411148219772 0.25621704669930856 7.0656968036614245 0.05612074494019469 0.13422090397774242 4.685857043518231e-06 5.329210965025916 -0.37933375906648087 HNST(ph)TSSTSSGGYR ddPTM_A459_Selumetinib_30min_R2 1 HNSTTSSTSSGGYR 14 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0 A0A0A0MRT6 ABI1 Abl interactor 1 1 HNS(0.218)T(0.737)T(0.025)S(0.019)S(0.002)TSSGGYR 196.45 0.00027267 5147200.0 4187.5 3686.3 5576.0 5101.7 7292.2 3940.4 4526.5 4580.7 4027.4 6647.2 True False 3954.7755138906637 3969.027356677306 5217.246230689764 4406.839659076621 6376.088642904866 4483.154332610208 4736.991219089589 4594.029078624295 4832.992534958087 6455.278064500272 0.6126421626419617 0.6148499440332883 0.8082140193744932 0.6826723210129866 0.9877326087576467 0.6944943792994093 0.7338167576606629 0.7116702073437229 0.7486885129761219 1.0 12.65626352638128 -14.522878745280336 0.18121547007889804 2.035540214391352 0.6850276700222351 0.3986877475860091 0.10050496061259932 152.50661575105815 1.4669747442930494 57.35205808794717 0.3210664670218112 3.0000000000000132e-15 14.522878745280336 -1.3505125443691168 HNSTT(ph)SSTSSGGYR ddPTM_A459_Selumetinib_30min_R1 1 HNSTTSSTSSGGYR 14 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0 A0A0A0MRT6 ABI1 Abl interactor 1 1 HNS(0.144)T(0.144)T(0.703)S(0.004)S(0.004)T(0.001)SSGGYR 117.2 0.0034437 4010300.0 69.113 144.38 167.64 118.77 243.28 149.14 206.18 198.21 0.0 0.0 True False 70.72319842951211 127.47592247955896 144.87540878060554 98.02904908902245 221.2753669545725 147.63978700828545 190.62767660352966 192.9528269231821 0.0 0.0 0.0 HNSTTSS(ph)TSSGGYR ddPTM_A459_Selumetinib_30min_R2 1 HNSTTSSTSSGGYR 14 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0 A0A0A0MRT6 ABI1 Abl interactor 1 1 HNS(0.011)T(0.151)T(0.151)S(0.089)S(0.439)T(0.151)S(0.007)S(0.003)GGYR 83.964 0.017662 50384000.0 0.0 705.61 934.28 590.01 2063.0 668.46 665.97 774.06 2181.9 721.2 True False 0.0 759.728018106251 874.1694419671512 509.64962017597946 1803.8274965459982 760.5342973242865 696.9389245945205 776.3123864474685 2618.3409673797123 700.3770820973638 0.0 1.0847414022045863 1.24814112898918 0.7276788935608403 2.575509026000992 1.0858926095165402 0.9950909908523172 1.1084206012605484 3.7384732229369555 1.0 9.451988066114112 -5.136336668827475 0.7799614321123807 1.6811296779140952 4.3370236942095193e-20 0.23509653326950075 0.8690321707765297 3.0187592728065606 1.9742490347693646 0.35962821495499336 4.0401564057903 7.305725177926593e-06 5.136336668827475 -1.6811296779140952 HNSWDT(ph)VNTVLPEDPEVADLFSR ddPTM_A459_Selumetinib_30min_R2 1 HNSWDTVNTVLPEDPEVADLFSR 23 0 Q8N961 Q8N961 ABTB2 Ankyrin repeat and BTB/POZ domain-containing protein 2 1 HNS(0.079)WDT(0.909)VNT(0.012)VLPEDPEVADLFSR 55.734 0.025480000000000003 1983400.0 1074.3 2733.2 2842.7 2997.0 922.48 1970.8 2455.6 1917.8 939.84 1274.6 True False 1014.5947067636403 2942.82765137683 2659.803776897739 2588.803429886633 806.589815324165 2242.2598108588454 2569.7902656790884 1923.3804804911194 1127.8342613236846 1237.7989861914864 0.819676472579275 2.377468138369906 2.1488172203804585 2.091457061095175 0.6516323121300297 1.8114894549703322 2.0760965991626237 1.5538714298103118 0.9111610801959484 1.0 10.273561330093914 -8.178225283104323 4.123562405526202 0.9516314119699666 1.7352025449302901 0.23464803440851678 0.5344675594360403 0.32386911607882546 9.78390187347344 0.419139434040603 0.14072433260110198 6.633988539101724e-09 8.178225283104323 0.7835711329603235 HNSWS(ph)SSSR ddPTM_A459_Selumetinib_30min_R1 1 HNSWSSSSR 9 0 H3BQ37;H3BPW9;Q96F86 H3BQ37 EDC3 Enhancer of mRNA-decapping protein 3 1 HNS(0.493)WS(0.495)S(0.012)SSR 163.46 0.00095829 4386800.0 999.46 1009.8 932.62 882.09 1129.2 1268.4 908.36 1062.0 443.03 520.43 True False 1022.7454733893798 891.5721465567157 805.9753265149627 728.0495403800273 1027.0640593764522 1255.6410476150547 839.841673875168 1033.83231013783 751.7895523690415 587.2322599174847 1.7416370713916354 1.5182615251450855 1.3724983818637873 1.2397982707597326 1.7489912075347678 2.138235811144796 1.4301695107710513 1.760516886935162 1.280225225492005 1.0 9.197787415354638 -8.501849548458353 4.08830345464862 1.0013227565272556 1.6085392798277591 0.4125084650111429 0.23967254388004894 0.19119032883527334 8.451298380110705 0.24642692049835596 0.06455373887889486 3.1488389695136433e-09 8.501849548458353 0.6072165233005036 HNT(ph)PSLLEAALTQEASTPDSQVWPTAPDITR ddPTM_A459_Selumetinib_30min_R1 2 HNTPSLLEAALTQEASTPDSQVWPTAPDITR 31 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 HNT(0.68)PS(0.32)LLEAALTQEASTPDSQVWPTAPDITR;HNT(0.68)PS(0.32)LLEAALTQEASTPDSQVWPTAPDITR 152.15 4.3399999999999996e-20 7892300.0 1265.27 1849.0 1364.81 1253.26 1407.17 1465.29 1938.25 1715.52 1087.06 1906.4700000000003 True False 1294.7483292131546 1632.5182204232206 1179.476298364699 1034.4016676038416 1279.8917219560421 1450.5505129768717 1792.046242005972 1670.0188368056972 1844.6614242789192 2151.183995090381 0.6018770742847389 0.7588928813849004 0.5482916854423435 0.48085225158082384 0.5949708276359076 0.6743033214673613 0.8330511225892048 0.7763254285161842 0.857509831092536 1.0 11.070915211306804 -7.758604889821048 0.7851484074325824 0.9654765630432828 0.5943371776575092 0.7442085796793961 0.07713055894179477 0.3599687876681825 0.4186503334392143 0.07814925629147222 0.03577040728338772 1.7433922464625706e-08 7.758604889821048 -0.3711393853857736 HNT(ph)PSLLEAALTQEASTPDSQVWPTAPDITR ddPTM_A459_Selumetinib_30min_R2 1 HNTPSLLEAALTQEASTPDSQVWPTAPDITR 31 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 HNT(0.499)PS(0.499)LLEAALT(0.002)QEASTPDSQVWPTAPDITR 55.662 0.0046731 3866800.0 6125.9 2118.0 5130.3 3423.2 5083.1 3489.3 3946.8 6065.7 3550.4 3189.1 True False 5785.447001920672 2280.44378955661 4800.222083448299 2956.9542546506236 4444.515534509436 3969.9194022882916 4130.334020435831 6083.350182769311 4260.579206464519 3097.0223967231036 1.8680675374004836 0.7363342906300908 1.549947487795799 0.954773287328925 1.4350931201569894 1.2818504013689997 1.33364680371897 1.964257730007371 1.3757017743793365 1.0 11.596666100843704 -7.546264742548799 24.99434668888031 1.531778283239963 1.2820766579648128 0.011881908953755738 0.3657462098391615 576.8833675743153 616550.3147310406 0.15840071088084645 0.09145880463434851 2.842727674409131e-08 7.546264742548799 -0.24970162527515005 HNTPS(ph)LLEAALTQEASTPDSQVWPTAPDITR ddPTM_A459_Selumetinib_30min_R2 1 HNTPSLLEAALTQEASTPDSQVWPTAPDITR 31 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 HNT(0.278)PS(0.722)LLEAALTQEASTPDSQVWPTAPDITR 75.301 2.0989e-05 3368800.0 7525.3 8613.4 10495.0 10290.0 11818.0 6806.7 8983.3 8268.5 2945.5 7813.5 True False 7107.073952162727 9274.02008355378 9819.763126092013 8888.484248759905 10333.317185739514 7744.261139929421 9401.041250071252 8292.55996607614 3534.682304146361 7587.903953088953 0.9366320391113431 1.22221105339353 1.2941338196689343 1.171401786805894 1.3618144417251001 1.020606110436706 1.238951007839812 1.0928657001121276 0.46583118684672203 1.0 12.889485702040991 -8.090965403208791 6.602855488759279 0.7375812443638206 1.183714033688041 0.5241387164582462 0.1671269092296889 0.17586526157338947 10.66218896294936 0.10693011302509244 0.03986764266616334 8.110256632520692e-09 8.090965403208791 0.4461327893242204 HNYYESFSLS(ph)PAAVADNVER ddPTM_A459_Selumetinib_30min_R1 1 HNYYESFSLSPAAVADNVER 20 0 B2WTI3;B2WTI4;K7EJU9;Q6NYC1-2;Q6NYC1;Q6NYC1-3 B2WTI3 JMJD6 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 1 HNYYES(0.002)FS(0.171)LS(0.828)PAAVADNVER 90.06200000000003 0.001154 6801900.0 870.56 914.6 1172.1 1009.4 961.51 872.37 1073.3 1101.7 399.58 700.05 True False 890.8423541851182 807.5182068139951 1012.9352578844417 833.1272387847036 874.5415902683782 863.5947498485856 992.3401168812129 1072.4793371740561 678.0580758314823 789.9082365644468 1.1277795482417867 1.0222936911332123 1.2823454814068123 1.054713953114642 1.107143272833852 1.0932849030725695 1.2562726541467708 1.3577264896471997 0.858401070459228 1.0 9.625541255288805 -8.28383490603627 24.99259841225954 0.9292004977065076 1.1573578114098828 0.4375067327346217 0.10576324049493976 897.101818620271 1001123.0657669811 0.10344067642616765 0.026788528126821667 5.201937068962509e-09 8.28383490603627 0.22815731370337522 HPAKPDPSGECNPDLR ddPTM_A459_Selumetinib_30min_R2 2 HPAKPDPSGECNPDLR 16 1 E9PC52;Q16576;Q16576-2;Q5JP01 E9PC52 RBBP7 Histone-binding protein RBBP7 0 ; 101.2 0.004464 5142900.0 33270.9 27415.6 34783.0 36760.0 33980.2 27493.0 29172.7 29866.2 26138.2 33240.4 False True 31421.836571965356 29518.288364951924 32545.09964886694 31753.224585462987 29711.303489157694 31279.91119339468 30529.2883546084 29953.105697384417 31366.570362328446 32280.66328306879 0.973395010394539 0.9144263271825108 1.0081917884858596 0.9836608469602778 0.9204056071778821 0.9689984037534011 0.9457453859264725 0.9278962279902974 0.9716829572947535 1.0 14.978382602073536 HPASLTSSGS(ph)SGSPSSSIK ddPTM_A459_Selumetinib_30min_R2 1 HPASLTSSGSSGSPSSSIK 19 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 HPASLTSS(0.001)GS(0.375)S(0.375)GS(0.246)PS(0.004)SSIK 204.78 5.8618e-16 2438300.0 8250.3 5516.1 8328.5 11617.0 9512.8 8366.8 8449.2 7237.8 7460.8 9580.8 True False 7791.781354567675 5939.1671329429755 7792.653377385167 10034.744559557226 8317.71701848898 9519.250753751661 8842.104541772176 7258.86079971771 8953.168472169466 9304.177410092105 0.8374497831604162 0.6383333927511795 0.837543506955552 1.0785203373994874 0.8939766141461226 1.0231157827478945 0.9503370531371506 0.7801722258481583 0.9622740493381065 1.0 13.183662890740187 -5.5245532056391555 24.99379281773259 0.9472636205611886 0.7379032859382124 0.503099546702855 0.08751026732797604 40.079138494313824 598238.1429331003 0.0234120255628707 0.04092934438607724 2.988455507318812e-06 5.5245532056391555 -0.2093603346229762 HPASLTSSGSSGS(ph)PSSSIK ddPTM_A459_Selumetinib_30min_R1 1 HPASLTSSGSSGSPSSSIK 19 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 HPASLTSSGS(0.001)S(0.08)GS(0.884)PS(0.025)S(0.008)S(0.002)IK 144.4 4.086300000000001e-05 7597600.0 1905.5 1987.8 1803.9 2112.0 2448.8 1741.1 2235.6 1973.7 668.0 1480.9 True False 1949.894442542435 1755.0674518968517 1558.940288113423 1743.1788471500843 2227.3064723707535 1723.5861147923158 2066.9668921081134 1921.3510645188665 1133.5472112103455 1670.9879401875437 1.166911140198647 1.0503172462752013 0.932945265863771 1.0432025302076318 1.3329279157578906 1.0314772915709187 1.2369729561759295 1.149829402301505 0.6783694746971792 1.0 10.70648560591612 -8.24419980687564 24.898437992699616 0.8391847270297654 1.1153864925521757 0.42623480400428737 0.12939932464363937 638.842841586844 922659.3150249742 0.0881091384557224 0.033124274262196086 5.6990201580671965e-09 8.24419980687564 0.27620176552241027 HPASLTSSGSSGS(ph)PSSSIK ddPTM_A459_Selumetinib_30min_R2 2 HPASLTSSGSSGSPSSSIK 19 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 HPASLTSS(0.001)GS(0.012)S(0.138)GS(0.849)PSSSIK;HPASLTSSGSS(0.031)GS(0.968)PSSSIK 176.88 5.4335e-13 17589300.0 62437.0 52311.0 83144.0 94542.0 104975.0 71891.0 64051.0 74820.0 65740.0 79567.0 True False 58967.00149511439 56323.08549362406 77794.60556034245 81665.21650595343 91787.10201159294 81793.33268847849 67029.49841464861 75037.71381288221 78889.83692907194 77269.69397010673 0.7631323286711464 0.7289156019617954 1.006793240185975 1.0568854658276141 1.1878797144855078 1.0585435050399166 0.8674746200053576 0.971114417017259 1.0209673790036233 1.0 16.237615063659312 -5.2776091046184925 7.103094920446961 1.0236580318722932 0.7453344947611744 0.6768362754850774 0.07605548426469004 0.0921536148540118 25.912961799226608 0.022505840842803278 0.050259122566762515 5.2770461876541224e-06 5.2776091046184925 -0.2783235371111188 HPDVEVDGFSELR ddPTM_A459_Selumetinib_30min_R1 1 HPDVEVDGFSELR 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 124.47 0.003166 3403700.0 930.23 1110.8 1248.8 1171.1 1159.3 954.42 1219.3 1189.3 821.01 910.91 False True 951.9025490875101 980.7470196030894 1079.219819167384 966.5893692696313 1054.441519691039 944.8194013440249 1127.3272193359383 1157.755900609154 1393.1940058021053 1027.834171514779 0.9261246370945577 0.9541879875016273 1.049994103209154 0.9404137321540034 1.025886810259526 0.9192333039011436 1.0967987352225608 1.126403395309286 1.355465739914907 1.0 10.005391806750835 -7.560222752586877 2.520754715217557 1.1843713117933004 0.973832808089612 0.47530728605429784 0.0907441941345778 0.22882839770035757 2.921510443959171 0.047638064792756736 0.02506194284994804 2.752816402966299e-08 7.560222752586877 -0.21053850370368832 HPDVEVDGFSELR ddPTM_A459_Selumetinib_30min_R2 2 HPDVEVDGFSELR 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 ; 133.15 0.0018992 4095700.0 12079.099999999999 8398.7 12118.599999999999 15000.699999999999 14345.1 11471.8 6085.700000000001 11687.900000000001 10462.8 11743.2 False True 11407.791978468475 9042.853283923083 11338.902469734036 12957.578782349152 12542.940291178867 13051.93631936802 6368.697108585778 11721.90985396399 12555.652355057728 11404.143303502167 1.0003199429250584 0.7929445503500521 0.9942791990567063 1.136216762408618 1.099858179380031 1.144490732185014 0.5584546720515144 1.027864131658556 1.1009728675719057 1.0 13.477270452835967 -5.483410542774336 23.096554603914157 1.0063359838964718 0.8958769622607446 0.06715921443184703 0.16621160756530345 652.409975123417 381782.38090126804 0.045604675078454095 0.09489092109531444 3.2854091113491678e-06 5.483410542774336 -0.11045902163572718 HPELADK ddPTM_A459_Selumetinib_30min_R2 1 HPELADK 7 0 P46783;A0A2R8Y6L3;F6U211;A0A2R8Y7H1;S4R435;A0A2R8YFH6;A0A1W2PQS6;Q9NQ39 P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 0 96.492 0.032471 4461000.0 50910.0 46342.0 39983.0 40369.0 42285.0 44063.0 67347.0 125900.0 62668.0 92437.0 False True 48080.62600887733 49896.28238698416 37410.53731019887 34870.67255959071 36972.780267303715 50132.278285910936 70478.76894554881 126266.34815613304 75203.35109022043 89768.10362983108 0.5356092427566836 0.5558353175503976 0.41674643662369715 0.3884528150821128 0.41186990447926974 0.5584642680281746 0.7851203946133917 1.4065836644695826 0.8377513621133175 1.0 16.453915297684894 -7.423643075392218 3.0106074752594507 1.0937028705608818 0.46906924549057427 0.7696557281911464 0.14734781411487013 0.11293786648829623 1.9664755844300748 0.06773681968903371 0.04130654163500359 3.770135199848876e-08 7.423643075392218 -0.6246336250703075 HPELTKPPPLMAAEPTAPLSHSASSDPADRLS(ph)PFLAAR ddPTM_A459_Selumetinib_30min_R2 1 HPELTKPPPLMAAEPTAPLSHSASSDPADRLSPFLAAR 38 2 Q9ULP9-2;Q9ULP9 Q9ULP9-2 TBC1D24 TBC1 domain family member 24 1 HPELTKPPPLMAAEPTAPLS(0.002)HS(0.002)AS(0.002)S(0.002)DPADRLS(0.993)PFLAAR 60.979 5.3755e-05 11294000.0 22110.0 16865.0 24974.0 26359.0 30135.0 23016.0 15890.0 17298.0 20579.0 22727.0 True False 20881.21471334271 18158.49127047792 23367.200029635253 22768.85872818876 26349.17188968186 26186.245081554287 16628.916485437665 17348.33431616193 24695.3750253023 22070.812458162483 0.9461008629802469 0.8227377811713649 1.05873764610751 1.03162757471432 1.1938469387853052 1.1864649355882586 0.7534347236631865 0.7860306161835908 1.1189155393402461 1.0 14.429852117811643 -10.29814000073041 8.56734558887508 0.9999957792958328 0.9860755903475183 0.0002424009813204453 0.15190227644289334 0.0 0.0 0.15868017465055698 0.038485595339747325 5.033383246802966e-11 10.29814000073041 -0.013920188948314483 HPEPVPEEGS(ph)EDELPPQVHKV ddPTM_A459_Selumetinib_30min_R1 5 HPEPVPEEGSEDELPPQVHKV 21 1 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV 131.33 2.5671e-05 98032500.0 10557.0 11664.7 12814.400000000001 12491.3 12330.800000000001 10635.7 11292.2 11450.2 6001.639999999999 9597.5 True False 10802.957559653896 10298.99150122809 11074.2748644607 10309.928945741402 11215.48131717956 10528.71451444295 10440.42026259762 11146.503500508652 10184.34473755758 10829.432612566645 0.9975552686959771 0.9510185685330346 1.0226089639830194 0.952028542453609 1.035648100729205 0.9722314077863381 0.9640782334692577 1.0292786242165701 0.9404319784712918 1.0 13.40267003722518 -3.7790524052075574 13.031073030177586 0.9867092085099907 0.9832900038673649 0.0 0.03336190203434509 0.0 0.0 0.006923523403522031 0.0 0.00016632119427175063 3.7790524052075574 -0.003419204642625795 HPEPVPEEGS(ph)EDELPPQVHKV ddPTM_A459_Selumetinib_30min_R2 5 HPEPVPEEGSEDELPPQVHKV 21 1 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV;HPEPVPEEGS(1)EDELPPQVHKV 105.38 7.556199999999999e-05 69572700.0 275707.0 221745.1 279707.0 285013.0 293395.0 217452.0 222169.0 252334.0 176317.0 258532.0 True False 260384.30868256814 238752.23614712377 261710.95614195487 246193.73772515164 256536.09711542056 247404.039167281 232500.29871952184 253068.25016385768 211585.3267085976 251067.50941319435 1.0371087413546636 0.9509483592884863 1.0423927681986285 0.9805878040554356 1.0217813436513854 0.9854084255884971 0.9260469395778507 1.007968935348662 0.8427427635026284 1.0 17.93771581630267 -7.08040730794697 4.757381219746753 0.9452314760455879 1.0040844275433 0.26373692339730503 0.04906992799099748 0.3137406572062863 12.649161387312008 0.01768105674525029 0.01375036787672164 8.309840578169794e-08 7.08040730794697 0.05885295149771219 HPGAHQGNLASGLHSNAIASPGS(ph)PSLGR ddPTM_A459_Selumetinib_30min_R2 1 HPGAHQGNLASGLHSNAIASPGSPSLGR 28 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 HPGAHQGNLASGLHSNAIAS(0.04)PGS(0.695)PS(0.265)LGR 88.194 1.2004e-05 3074000.0 11318.0 7932.2 11566.0 11696.0 12949.0 9193.3 8376.5 7552.4 6321.9 9418.6 True False 10688.99086954377 8540.574233957004 10821.856152108654 10102.984623274619 11322.23085447122 10459.593626531667 8766.023847719858 7574.376233632869 7586.456648644669 9146.66054553831 1.1686222328167408 0.9337368749431778 1.183148330281864 1.1045544516465955 1.2378540559258144 1.1435423425256332 0.9583851728263684 0.8281029120871449 0.8294236580524791 1.0 13.159029394858937 -7.415461985334609 3.5734552062857925 0.8736531960530384 1.12572381325007 0.6195655192969969 0.08719493290143754 0.16088968101262063 3.75981793023934 0.04070061932998497 0.025674408455359593 3.8418288600411224e-08 7.415461985334609 0.2520706171970316 HPGCT(ph)TPVTVK ddPTM_A459_Selumetinib_30min_R1 2 HPGCTTPVTVK 11 0 Q96Q89-5;Q96Q89-3;Q96Q89;Q96Q89-2;Q96Q89-4 Q96Q89-5 KIF20B Kinesin-like protein KIF20B 1 HPGCT(0.499)T(0.499)PVT(0.002)VK;HPGCT(0.5)T(0.5)PVTVK 118.77 0.012194 12954000.0 4053.8 4940.8 5494.6 5640.7 4611.5 5109.1 5011.2 4286.4 2871.1 4046.3999999999996 True False 4148.245652678312 4362.328839084395 4748.463499677373 4655.65763405278 4194.3906392264535 5057.707092691641 4633.201149459731 4172.7107478105445 4872.047003152732 4565.794855273734 0.9085484092406975 0.9554368904782647 1.0400080709260615 1.0196817381480137 0.9186550802609343 1.1077385763071947 1.0147633208067022 0.913906752291081 1.0670753193226061 1.0 12.156650324266744 -5.007779671628775 3.923932412864648 1.0077501842175058 0.9138593231256443 0.25307256886065654 0.05627411254724529 0.291161300702658 10.10090385028983 0.014209505781913302 0.05667101648579331 9.82246134483314e-06 5.007779671628775 -0.09389086109186151 HPHDIIDDINSGAVECPAS ddPTM_A459_Selumetinib_30min_R1 2 HPHDIIDDINSGAVECPAS 19 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 ; 145.94 6.8173e-05 26231000.0 6323.2 7128.7 6706.0 7452.1 6784.6 5776.3 6234.5 6159.0 3486.6 5480.9 False True 6470.5182571946125 6294.0684899572825 5795.362033421262 6150.730628242016 6170.934127918418 5718.195666460768 5764.226645575252 5995.643312748493 5916.505548811363 6184.426903487005 1.0462599620259556 1.017728657510441 0.9370895838632398 0.9945514312367424 0.9978182658184578 0.9246120547138557 0.9320551015527683 0.969474359761279 0.9566780626795706 1.0 12.59442419485079 -5.082509047786281 4.377190051791396 0.962848432413065 1.0410780350089706 0.5297841017460749 0.02615589224676281 0.1594313079089219 5.405971193620428 0.0069968596896707695 0.021787972921385495 8.269722798286767e-06 5.082509047786281 0.07822960259590561 HPHDIIDDINSGAVECPAS ddPTM_A459_Selumetinib_30min_R2 2 HPHDIIDDINSGAVECPAS 19 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 ; 99.747 0.0018754 13422800.0 45794.0 48787.0 57183.0 45957.0 59296.0 45957.0 34254.0 47254.0 34924.0 51651.0 False True 43248.952807906644 52528.806025070044 53503.90803614291 39697.57731975308 51846.706367034196 52287.159593890814 35846.878873013324 47391.50131667917 41909.77585809114 50159.70142458531 0.8622250846714284 1.0472312341022736 1.0666711825744335 0.7914237164955628 1.0336326751263718 1.0424136928427319 0.7146549491908121 0.9448122690269974 0.8355268206909512 1.0 15.614241140078713 -7.220798251595392 24.995079436806492 0.8691491873646883 0.9758977888925513 0.17145697522524395 0.10764940001434459 860.8861284469461 529462.1323774587 0.040084668430598894 0.03104909023273365 6.014530733327626e-08 7.220798251595392 0.10674860152786303 HPLLSSGGPQS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 1 HPLLSSGGPQSPLR 14 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 HPLLSS(0.002)GGPQS(0.998)PLR 104.16 0.006381 8790800.0 158.53 331.11 327.29 167.03 274.79 226.13 257.04 301.11 149.32 113.06 True False 162.22344055431768 292.34348727113706 282.8458156752828 137.8613460414197 249.93529301811486 223.85533750961238 237.6512658559088 293.12358465687595 253.38513409869591 127.57235229765935 1.2716191058060007 2.291589690131479 2.2171403958698686 1.0806522225109831 1.9591650425552323 1.7547323810985305 1.8628743734489337 2.2977046309606544 1.9862072740297423 1.0 6.995171889371561 -11.293245084221379 2.6144647924086932 0.7812981514455581 1.8714386529030016 0.30619637928198074 0.3869660726739844 15067420.72132745 11031542.672024101 21109544.83357013 0.09867136058084404 5.090435228416673e-12 11.293245084221379 1.0901405014574435 HPLLSSGGPQS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 3 HPLLSSGGPQSPLR 14 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 HPLLSSGGPQS(1)PLR;HPLLS(0.144)S(0.183)GGPQS(0.673)PLR;HPLLSS(0.002)GGPQS(0.997)PLR 156.0 0.00021443 15822600.0 21304.3 18268.6 20244.5 23547.6 28770.6 17348.4 20113.5 23208.8 13752.8 20104.2 True False 20120.29229387007 19669.74287719257 18941.990910545 20340.376258124277 25156.18001557262 19737.984626904607 21048.817604144144 23276.33376557632 16503.74428533834 19523.73950901529 1.0305552522138146 1.0074782481148072 0.9702030137104799 1.0418278859299417 1.2884918897814885 1.010973569781055 1.078114036218555 1.1922067365643878 0.8453167630984609 1.0 14.252941787696752 -1.9494718152502641 17.86445694365533 1.0551332657318573 0.14735580135639303 0.0 0.11534794339010786 0.0 0.0 0.02597751137595626 0.0 0.011233838724332517 1.9494718152502641 -0.9077774643754642 HPPDDDLSQDSPEQEAS(ph)KSPR ddPTM_A459_Selumetinib_30min_R2 2 HPPDDDLSQDSPEQEASKSPR 21 1 Q9P0K8-2;Q9P0K8 Q9P0K8-2 FOXJ2 Forkhead box protein J2 1 HPPDDDLSQDS(0.01)PEQEAS(0.495)KS(0.495)PR;HPPDDDLSQDS(0.019)PEQEAS(0.49)KS(0.49)PR 76.52600000000002 0.0011978 25980000.0 94616.0 85456.0 99657.0 92658.0 105267.0 73909.0 82937.0 81209.0 58757.0 96865.0 True False 89357.62149785772 92010.20041565159 93245.17711833754 80037.82055603439 92042.4183610799 84089.29387089827 86793.73483654765 81445.30474512641 70510.04180775005 94068.25576450542 0.9499232315049988 0.9781216805592096 0.9912501976412913 0.8508483537358721 0.9784641759649813 0.893917859829474 0.9226676324671191 0.8658107252357283 0.7495625515186332 1.0 16.521420333346867 -7.241704206619468 1.2921124478328723 0.8616683692719638 0.9495014565535767 0.1615092091611735 0.06888115495369648 0.7166748193833401 2.3398892680636822 0.04225270203757954 0.024818672838560495 5.7318628919257255e-08 7.241704206619468 0.08783308728161288 HPPDDDLSQDSPEQEASKS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 HPPDDDLSQDSPEQEASKSPR 21 1 Q9P0K8-2;Q9P0K8 Q9P0K8-2 FOXJ2 Forkhead box protein J2 1 HPPDDDLSQDSPEQEAS(0.236)KS(0.764)PR;HPPDDDLS(0.005)QDS(0.004)PEQEAS(0.283)KS(0.708)PR 143.35 5.1608000000000015e-06 14226000.0 1604.59 1826.7399999999998 1899.68 1909.41 1975.1399999999999 1743.51 1662.26 1815.55 935.52 1507.88 True False 1641.9738250113712 1612.8644315716137 1641.7138901953049 1575.9673875647911 1796.4889357392904 1725.9718723804187 1536.8743899067965 1767.3957162624652 1587.509112322609 1701.431085994999 0.9650545582051259 0.9479457880178607 0.9649017839798246 0.9262598999965747 1.055869350528941 1.0144236146779158 0.9032833610231299 1.0387700864351435 0.9330434393669443 1.0 10.732533002872616 HPPFSPPEPPLS(ph)SPASQHK ddPTM_A459_Selumetinib_30min_R2 1 HPPFSPPEPPLSSPASQHK 19 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 HPPFSPPEPPLS(0.576)S(0.413)PAS(0.011)QHK 62.002 0.017475 9916600.0 29448.0 24686.0 44256.0 45115.0 58288.0 27952.0 19978.0 29589.0 24462.0 38085.0 True False 27811.398049684136 26579.336821999288 41408.61714228951 38970.259172284066 50965.34033866853 31802.134277007543 20907.016585656005 29675.099091277367 29355.083525387272 36985.38709328632 0.7519563869789139 0.7186442784811095 1.1195939909415227 1.053666386510743 1.377985857228459 0.8598567373864351 0.565277755047509 0.8023465866783929 0.7936941000873255 1.0 15.174667754825157 -6.992030824550823 24.998774961987074 0.7651025560643875 1.009764390262043 0.20285839368475023 0.19952549103083692 286.7561514017247 899530.1068169739 0.07515864588724941 0.06616899283302642 1.0185190949232983e-07 6.992030824550823 0.24466183419765553 HPPFSPPEPPLSS(ph)PASQHK ddPTM_A459_Selumetinib_30min_R1 1 HPPFSPPEPPLSSPASQHK 19 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 HPPFSPPEPPLS(0.203)S(0.793)PAS(0.004)QHK 160.67 1.1049e-06 19444000.0 2436.1 2632.0 3081.2 3076.8 3957.7 2583.8 3716.3 2717.2 892.14 1993.7 True False 2492.85639017456 2323.8442164163957 2662.789963820102 2539.4946386890974 3599.726733788687 2557.8093179026973 3435.976498989707 2645.1310292905027 1513.896420672451 2249.6108152825336 1.1081278473767813 1.0329983304799053 1.1836669461805003 1.1288595438096507 1.6001553287947672 1.1370008094406572 1.5273648560220738 1.1758171730510172 0.6729592560579495 1.0 11.135459720136884 -8.139629565610333 5.97012221725132 0.8425526963603688 1.246922747023116 0.42344421478778616 0.18792372034886487 0.21517692895136858 9.381311289153832 0.13245448159127726 0.04871527208721235 7.2505413618469975e-09 8.139629565610333 0.4043700506627471 HPPFSPPEPPLSS(ph)PASQHK ddPTM_A459_Selumetinib_30min_R2 3 HPPFSPPEPPLSSPASQHK 19 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 HPPFSPPEPPLS(0.217)S(0.777)PAS(0.006)QHK;HPPFSPPEPPLS(0.43)S(0.568)PAS(0.002)QHK;HPPFSPPEPPLS(0.217)S(0.779)PAS(0.004)QHK 183.6 1.2215e-13 17927300.0 42026.8 28654.6 50041.0 55521.0 80441.0 46130.3 45526.7 44398.8 40511.5 56968.0 True False 39691.1187026102 30852.315680939028 46821.41654052128 47958.94402093283 70335.28242833579 52484.33009583003 47643.78175944464 44527.99315738301 48614.93198588534 55323.18581936026 0.7174409447823294 0.5576742413511246 0.8463253850456348 0.8668868813435121 1.271352713815011 0.948685968071333 0.861190133102779 0.8048703721216378 0.8787442600399311 1.0 15.755596616902881 -5.493425375244091 2.800940365731293 0.9488243648464426 0.6384023871518769 0.47862354887855263 0.12706696612400928 0.2449363602165887 3.8079216901213897 0.038401413126051574 0.08735961765781318 3.210514419030115e-06 5.493425375244091 -0.3104219776945657 HPPLYQAGLTPPLS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 HPPLYQAGLTPPLSPPK 17 0 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 HPPLYQAGLTPPLS(1)PPK;HPPLYQAGLTPPLS(1)PPK 116.73 0.0010655 103938000.0 4780.6 6056.1 6305.6 6354.1 4414.3 5156.299999999999 5206.3 5371.3 3211.8999999999996 5150.2 True False 4891.978678571694 5347.048996595491 5449.334154181499 5244.475716229327 4015.0273444079667 5104.432303545811 4813.584599383821 5228.835675558691 5450.359712105552 5811.278337196221 0.8418076703123355 0.9201157966175291 0.9377169424671973 0.9024650708366585 0.6909026054919793 0.8783665154831589 0.8283176815974436 0.8997737454925377 0.9378934196318667 1.0 12.504639840352816 -8.376316344392272 1.773563249710382 0.9971464273689613 0.859079243692384 0.33147624102894835 0.06507171697236173 0.43032044207217596 2.7638111957391716 0.06572987924671102 0.019084597403795575 4.204202785384241e-09 8.376316344392272 -0.13806718367657733 HPPLYQAGLTPPLS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 HPPLYQAGLTPPLSPPK 17 0 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 HPPLYQAGLTPPLS(1)PPK;HPPLYQAGLTPPLS(1)PPK 106.39 0.0016904 56211000.0 204744.0 180991.0 172099.0 159392.0 142435.0 125371.0 157270.0 156622.0 107220.0 137498.0 True False 193365.14813517127 194872.42772221024 161026.33770722325 137682.5346334633 124541.041914944 142639.7172453748 164583.3666245928 157077.74408983198 128666.99597710816 133528.07547729224 1.4481235309053406 1.4594116407777495 1.2059361833205435 1.0311130010772722 0.9326955508777884 1.0682376476670787 1.2325749924597829 1.1763649219713692 0.9635950755464101 1.0 17.02678358783548 -5.409225498702711 2.900084059263144 1.0685801067241267 1.4596570671191684 0.7641005346153604 0.08695299809740627 0.13732399745121765 2.19007937102095 0.02644462376537319 0.06491567429166156 3.8973956967280416e-06 5.409225498702711 0.3910769603950417 HPPVLT(ph)PPDQEVIR ddPTM_A459_Selumetinib_30min_R1 2 HPPVLTPPDQEVIR 14 0 P05771-2 P05771-2 PRKCB Protein kinase C beta type 1 HPPVLT(1)PPDQEVIR;HPPVLT(1)PPDQEVIR 129.36 0.0014358 8953300.0 1914.56 2463.2 2719.7 2597.5 2334.9 2463.7 2632.2 2346.4 1374.48 2202.46 True False 1959.1655229147445 2174.8073988893884 2350.3796782427407 2143.895386113797 2123.7087072600775 2438.91741486062 2433.651034803622 2284.1658498186503 2332.3921719526875 2485.1671947771324 0.7883435476824894 0.875115124431064 0.9457631998291047 0.8626765195595058 0.8545536540653274 0.9813896706774048 0.9792705456269593 0.9191195886615154 0.9385252536949951 1.0 11.27912720001571 -6.759026499587127 24.999827698237947 0.9595815870755715 0.8701617130065621 0.5808524830916271 0.04160699251644659 54.35592269182495 563182.9065908133 0.014758419890914982 0.01409480480877909 1.7417005958385878e-07 6.759026499587127 -0.08941987406900942 HPPVLT(ph)PPDQEVIR ddPTM_A459_Selumetinib_30min_R2 1 HPPVLTPPDQEVIR 14 0 P05771-2 P05771-2 PRKCB Protein kinase C beta type 1 HPPVLT(1)PPDQEVIR 118.31 0.0032234 4479300.0 11032.0 8612.7 10546.0 8745.0 9116.3 9117.8 8635.8 10926.0 5798.1 7892.8 True False 10418.885604595065 9273.266395804629 9867.481841616618 7553.915914033562 7971.028893243956 10373.694186852434 9037.381811513069 10957.792851103322 6957.882012449838 7664.914356042809 1.3592957625653181 1.2098330085702573 1.2873570901463973 0.9855186324525937 1.0399371112294054 1.3533998822405753 1.1790584201881191 1.4296040819379146 0.9077573067681355 1.0 12.904053956676263 -4.733629690379821 1.423714364217222 1.1599793647052579 1.445235474385716 0.13852086136730946 0.1609378279106552 3.118806871484554 5.3131105907228156 0.04612204767494393 1.3211468922678418 1.8465892782860322e-05 4.733629690379821 0.2852561096804582 HPQGEQMYR ddPTM_A459_Selumetinib_30min_R1 2 HPQGEQMYR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 175.91 0.00053804 5707200.0 0.0 128.95 65.975 147.08 146.47 226.78 0.0 0.0 126.11 0.0 False True 0.0 113.85247405277136 57.01595737473424 121.395239033539 133.22181436137882 224.49879909976517 0.0 0.0 213.99945929002507 0.0 0.0 HPQGEQMYR ddPTM_A459_Selumetinib_30min_R2 2 HPQGEQMYR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 138.06 0.0035113 11463800.0 501.12 0.0 765.67 0.0 947.94 0.0 0.0 534.98 0.0 0.0 False True 473.269756542302 0.0 716.4076257984636 0.0 828.8513025088777 0.0 0.0 536.5367032292934 0.0 0.0 0.0 HPRPTETAS(ph)DSEGNFETPEAETPIR ddPTM_A459_Selumetinib_30min_R1 3 HPRPTETASDSEGNFETPEAETPIR 25 1 E5RFM9 E5RFM9 TACC1 1 HPRPT(0.015)ET(0.006)AS(0.974)DS(0.006)EGNFETPEAETPIR;HPRPT(0.153)ET(0.153)AS(0.346)DS(0.346)EGNFET(0.001)PEAETPIR;HPRPT(0.282)ET(0.282)AS(0.379)DS(0.056)EGNFETPEAETPIR 101.87 1.3706e-06 30710000.0 2594.23 3244.7299999999996 3191.5 3072.04 3734.0699999999997 2999.8399999999997 3366.08 2961.2300000000005 1997.08 2813.15 True False 2654.6705115071445 2864.835503165947 2758.111829654632 2535.565883332833 3396.3240278036046 2969.664333236791 3112.1738755534443 2882.6885609693472 3388.8988990478406 3174.2452049014696 0.83631551444355 0.9025249526225159 0.8689032042627738 0.7987933255495108 1.0699627182421871 0.9355497579869452 0.9804453262614437 0.9081493000345661 1.067623538917194 1.0 11.632197862813596 -6.254116134585055 24.99884344660822 0.9854668159854336 0.8565027964610599 0.6260588692472853 0.05348378586353802 408.57409756677356 1394720.1620636503 0.015466106978778319 0.019556842162211967 5.570367719419594e-07 6.254116134585055 -0.12896401952437375 HPRPTETASDS(ph)EGNFETPEAETPIR ddPTM_A459_Selumetinib_30min_R2 1 HPRPTETASDSEGNFETPEAETPIR 25 1 E5RFM9 E5RFM9 TACC1 1 HPRPT(0.281)ET(0.067)AS(0.281)DS(0.37)EGNFETPEAETPIR 60.735 0.0027912 12839000.0 15149.0 15597.0 19111.0 19209.0 21314.0 16252.0 15721.0 15238.0 15739.0 20537.0 True False 14307.079226251872 16793.239747740532 17881.419066483522 16592.701062626726 18636.344770422405 18490.565479032866 16452.05765057052 15282.34005721331 18887.239784403188 19944.043448465833 0.7173610137392888 0.8420178080304136 0.8965794279724669 0.8319627414321089 0.934431617067901 0.9271222020154206 0.8249108408273185 0.7662608686499268 0.9470115642901922 1.0 14.283670310432631 -14.522720737167386 0.018684345378681102 2.0673506891443267 1.2054050051402996e-06 0.3585902274587398 0.06665123220135497 5257.397431702995 7.4135028230991304 542.6242884112869 308.2487602773738 3.0010916799557087e-15 14.522720737167386 -2.0673494837393216 HPS(ph)GGSSPPPR ddPTM_A459_Selumetinib_30min_R2 1 HPSGGSSPPPR 11 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 HPS(0.945)GGS(0.044)S(0.012)PPPR 108.98 0.0081211 0.0 491.76 0.0 669.33 0.0 696.05 0.0 452.98 686.65 0.0 971.3 True False 464.4299478712535 0.0 626.2660365114025 0.0 608.6059762340485 0.0 474.04446756284176 688.6480378189731 0.0 943.2560452595249 0.4923689068363951 0.0 0.6639406549884272 0.0 0.6452182090882845 0.0 0.5025618122939403 0.7300754034706455 0.0 1.0 9.881505630967533 -14.512175644984351 0.3777710213128154 9.999999999995534 0.32738668973538604 0.3057305979443776 0.2954943615190395 685.4413950517678 5.213302694232651 5049.554263151502 0.18607103767574193 3.074852977309814e-15 14.512175644984351 -9.672613310260148 HPS(ph)SPSALR ddPTM_A459_Selumetinib_30min_R2 4 HPSSPSALR 9 0 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 HPS(0.965)S(0.035)PSALR;HPS(0.856)S(0.143)PSALR;HPS(0.869)S(0.131)PSALR;HPS(0.858)S(0.14)PS(0.002)ALR 117.71 0.0059401 97169300.0 24568.2 23706.75 42120.04 56266.9 48571.9 33933.74 27965.589999999997 30742.0 42952.53 46877.1 True False 23202.797798296975 25524.9814957843 39410.08248323207 48603.25115418356 42469.86368370462 38607.80466517821 29266.04534776532 30831.45413038792 51544.23619396221 45523.636321667116 0.5096868280544964 0.5606973334780729 0.8657059423979873 1.0676487003532864 0.9329189650759722 0.8480826178378618 0.6428758269873985 0.6772625524141971 1.1322521740081113 1.0 15.474328180904564 -5.247554026002189 4.743009305009228 0.8821904824691805 0.5262886689365688 0.4922527580461984 0.1463795686571508 0.1684980172206385 10.797577619791396 0.04066862659090984 0.10505565740691739 5.655174026495934e-06 5.247554026002189 -0.35590181353261174 HPSGGS(ph)SPPPR ddPTM_A459_Selumetinib_30min_R2 1 HPSGGSSPPPR 11 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 HPSGGS(0.895)S(0.105)PPPR 137.09 0.00090066 3231200.0 927.35 833.42 1063.3 1029.4 3493.1 1695.2 442.78 1006.8 1161.8 2932.7 True False 875.8115994761808 897.3406341323273 994.8884356335051 889.1939441859519 3054.265549289787 1928.698412506554 463.3701473519252 1009.729621315287 1394.1924634042568 2848.025330930309 0.30751538266343176 0.3150746674852118 0.34932569764347016 0.3122141978616097 1.0724151629269778 0.6772054979849998 0.16269874509878923 0.35453674177310013 0.4895295165611618 1.0 11.475746262653553 HPSGGSS(ph)PPPR ddPTM_A459_Selumetinib_30min_R2 2 HPSGGSSPPPR 11 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 HPSGGS(0.202)S(0.798)PPPR;HPSGGS(0.238)S(0.762)PPPR 99.834 0.011155 4219400.0 700.04 487.87 2186.3 3785.7200000000003 3076.3399999999997 711.47 1122.3 2930.4 2149.6 2213.8 True False 661.1345792821542 525.2880602507003 2045.6358382634562 3270.0984052687418 2689.862666371458 809.4685344183798 1174.48917379526 2938.926978846166 2579.5800648423074 2149.881841856828 0.30752135601607755 0.24433345592472888 0.9515108218676168 1.521059595742432 1.2511676753585002 0.37651768513903594 0.546304057706198 1.367017908439028 1.1998706229428655 1.0 11.070041655708662 -5.286138675485386 5.757548356409339 1.0277499621712995 0.27180689959362375 0.4511971172398548 0.3316549041181755 0.16106129483473142 18.460311362741216 0.09704559756876274 0.21895418376449707 5.17441580208126e-06 5.286138675485386 -0.7559430625776757 HPSS(ph)PSALR ddPTM_A459_Selumetinib_30min_R1 1 HPSSPSALR 9 0 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 HPS(0.218)S(0.74)PS(0.042)ALR 88.134 0.031598 14096000.0 2192.5 2726.4 2215.0 2325.3 3665.1 2492.2 3241.6 2494.1 1245.0 1583.5 True False 2243.580984137649 2407.191820531026 1914.2151661240841 1919.230006286974 3333.592352125961 2467.130730736549 2997.083502172867 2427.948366021434 2112.6740687977253 1786.757649596175 1.2556716825276895 1.3472402488804653 1.0713345296474404 1.074141200246569 1.8657216063294235 1.3807864381015216 1.6773866913905406 1.3588571268018215 1.1824066175260033 1.0 10.803128249519059 HPT(ph)PRT(ph)GWT(ph)ARRR ddPTM_A459_Selumetinib_30min_R2 1 HPTPRTGWTARRR 13 3 Q96NT3-3;A0A087WVD9 Q96NT3-3 GUCD1 3 HPT(1)PRT(1)GWT(1)ARRR 66.78399999999999 0.033724000000000004 2183500.0 24920.0 24178.0 19799.0 21693.0 19916.0 16422.0 16273.0 10743.0 9752.5 18567.0 True False 23535.046162663966 26032.374855476723 18525.15389552129 18738.375977487718 17413.974028700977 18683.98143592651 17029.72674433778 10774.260351400611 11703.272507617512 18030.92246714053 1.305260238656903 1.4437627860093125 1.0274102131647143 1.0392355694300415 0.9657838671557776 1.0362188329507884 0.9444734053608557 0.5975434906913705 0.6490667645510373 1.0 14.13818558689793 -5.543025414000267 0.4997117305179202 0.7642478227146249 1.5661405667052513 0.6523975829019808 0.14236615174334047 1.4161398289548375 0.4658475140894084 0.1083324170566443 0.6160385838358289 2.8640103691356725e-06 5.543025414000267 0.8018927439906264 HPT(ph)TPSSTAK ddPTM_A459_Selumetinib_30min_R2 1 HPTTPSSTAK 10 0 O60885 O60885 BRD4 Bromodomain-containing protein 4 1 HPT(0.557)T(0.423)PS(0.016)S(0.003)T(0.001)AK 108.31 0.025155 2215000.0 8385.7 7839.0 7651.4 7905.2 8516.5 7940.2 14754.0 27537.0 12455.0 18418.0 True False 7919.656364616827 8440.226093642239 7159.117254214428 6828.498122769372 7446.581131523992 9033.8904760409 15440.090234496363 27617.128111004244 14946.34802177657 17886.22448428903 0.4427796582545034 0.47188416432187785 0.40025871644979527 0.38177414852236785 0.4163305195048261 0.5050753155858088 0.8632392066899691 1.5440445877922802 0.8356345988447814 1.0 14.126561267630484 -7.377043632870858 3.159448522782149 1.1504202349372352 0.4287915015751762 0.7649247188684766 0.17300900804913644 0.10943313281378608 2.069664439482079 0.07514246297970516 0.04753231049864607 4.1971681359677e-08 7.377043632870858 -0.721628733362059 down HPTT(ph)PSSTAK ddPTM_A459_Selumetinib_30min_R1 2 HPTTPSSTAK 10 0 O60885 O60885 BRD4 Bromodomain-containing protein 4 1 HPT(0.218)T(0.78)PS(0.002)STAK;HPT(0.024)T(0.973)PS(0.002)S(0.001)TAK 104.82 0.030135 2920000.0 2180.44 3328.2 3003.7 2854.9 3059.7 3032.1000000000004 2788.9 2747.8 2178.77 2102.91 True False 2231.2400096023243 2938.5327967617977 2595.8140381430735 2356.3453081102143 2782.95067523391 3001.599826926529 2578.5310276437285 2674.9194178876933 3697.2135589352783 2372.8389825780196 0.9403250814676636 1.238403793235548 1.0939697371807329 0.9930489702045078 1.172835871151407 1.264982516287464 1.086686052688763 1.1273075996844388 1.5581392526341442 1.0 11.212398489316262 -6.503217523382385 20.545389322181105 1.2090643796348308 1.0809686424806668 0.15347591329183163 0.15582489565314192 160.61709967165123 167839.8806123708 0.04767275978581781 0.05304192160983131 3.138936113401057e-07 6.503217523382385 -0.128095737154164 HQAFEAELHANADR ddPTM_A459_Selumetinib_30min_R1 1 HQAFEAELHANADR 14 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 104.9 0.0033901 7266700.0 1059.2 1365.6 1561.4 1258.1 1735.5 1217.1 887.9 1156.7 655.32 965.64 False True 1083.877299155575 1205.7149171497838 1349.370456156273 1038.3964524618943 1578.5243314274105 1204.8570790383812 820.9249881476092 1126.020558508878 1112.0301773209044 1089.589300130124 0.9947576568768922 1.106577420506783 1.2384211702474728 0.9530163818035695 1.4487333266203106 1.1057901164177102 0.7534260735210692 1.0334357710509852 1.0205957209639451 1.0 10.089568725792658 -7.020461127315461 24.813790735982597 0.9510731653965969 1.1538528037290898 0.2889587671852947 0.14665027105116057 893.6584122863107 1083762.8107754432 0.05485844326748831 0.0430329271098998 9.53979127463349e-08 7.020461127315461 0.2027796383324929 HQAFEAELHANADR ddPTM_A459_Selumetinib_30min_R2 2 HQAFEAELHANADR 14 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 ; 126.56 0.00072618 9438000.0 21005.8 16782.5 18376.9 21527.8 20470.5 16215.8 16444.1 15107.900000000001 14610.7 21335.5 False True 19838.38172887988 18069.663785757213 17194.55026125588 18595.6765024736 17898.81278140808 18449.37925762374 17208.783233365983 15151.861487752518 17533.248257067127 20719.488678713686 0.9574744838785998 0.8721095421780949 0.82987329117445 0.8974968828057037 0.8638636338451997 0.890436030720094 0.8305602276298232 0.7312854927408943 0.84622012294541 1.0 14.338700779785 -7.268755265890007 22.331438924357972 0.8296235657989697 0.8816865882656717 0.011579802793332927 0.0693823812212699 303.5612648105291 926595.5347480358 0.02746356927152473 0.019005445384050048 5.3857319438491794e-08 7.268755265890007 0.052063022466702025 HQAS(ph)DSENEEPPKPR ddPTM_A459_Selumetinib_30min_R2 1 HQASDSENEEPPKPR 15 1 Q96ST2;B8ZZB6 Q96ST2 IWS1 Protein IWS1 homolog 1 HQAS(1)DSENEEPPKPR 93.812 0.039355 0.0 4685.4 3926.4 4598.0 4385.0 4077.7 3921.6 4660.1 5494.2 4468.7 5257.3 True False 4425.004225142287 4227.542254634121 4302.169685923877 3787.75543545308 3565.4228708994738 4461.764803259615 4876.803883812971 5510.187212386228 5362.564865910319 5105.5080888941675 0.8667118234065369 0.8280355610110862 0.8426526040145222 0.7418958837206528 0.6983482953744041 0.8739120035800424 0.9552044182284838 1.0792632420605395 1.0503489119085558 1.0 12.317838826735311 -7.316468171925732 2.297975800337902 1.0455191736148544 0.7975717043962485 0.8092153376485804 0.05228702326779164 0.13611096314094973 1.4064086729876482 0.028107350442657233 0.017628218032291487 4.8253834247870404e-08 7.316468171925732 -0.2479474692186059 HQEGEIFDTEK ddPTM_A459_Selumetinib_30min_R1 2 HQEGEIFDTEK 11 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 ; 178.71 0.00079687 15736400.0 2908.6 2857.0 2431.7 2279.4 2522.6000000000004 2260.1 2793.2 2358.9 1297.27 2281.5 False True 2976.3647208496077 2522.5011118167326 2101.488496371978 1881.3455796372623 2294.431275401203 2237.3654460066105 2582.506675181777 2296.334309212927 2201.372441147971 2574.3527486919324 1.1561604066738498 0.9798583791978211 0.8163172267047614 0.7308033371080177 0.8912653002068338 0.8690982411572966 1.0031673695432717 0.8920045282759829 0.8551168608367761 1.0 11.329994035936522 -4.876681337854401 3.0861105038903003 0.8776262533812406 1.1719696949277725 0.5478125437307302 0.07596691747106976 0.23467837263483968 3.7122520958508733 0.020565572056749023 0.15110872737893663 1.3283687864524028e-05 4.876681337854401 0.2943434415465319 HQEGEIFDTEK ddPTM_A459_Selumetinib_30min_R2 2 HQEGEIFDTEK 11 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 ; 103.97 0.017924000000000002 53972000.0 577990.0 484500.0 539710.0 513260.0 564580.0 481290.0 587180.0 616580.0 461300.0 567080.0 False True 545867.6296772932 521659.5920869585 504985.6461918162 443353.102577115 493652.412990761 547583.3287843786 614485.0334750965 618374.1457196858 553572.8897989196 550706.9269492152 0.9912125723590758 0.9472544588767532 0.9169771097474949 0.8050617867350702 0.896397682385216 0.9943280209273185 1.1158113388534927 1.1228733750369382 1.0052041525345996 1.0 19.07092522967053 -6.969745118579796 3.811072990941086 1.0704975447865288 0.9085461494226318 0.5952819710023656 0.057908757134791364 0.15553498530196144 4.904234277209902 0.023354731431979255 0.01962140324416222 1.0721483496572444e-07 6.969745118579796 -0.16195139536389702 HQEVQDQDPVFQGS(ph)DSSGYQSDHKK ddPTM_A459_Selumetinib_30min_R2 1 HQEVQDQDPVFQGSDSSGYQSDHKK 25 1 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 HQEVQDQDPVFQGS(0.509)DS(0.048)S(0.048)GY(0.176)QS(0.22)DHKK 98.002 3.8775e-06 15770000.0 97905.0 74515.0 100230.0 112290.0 118280.0 85972.0 70181.0 86790.0 62860.0 93437.0 True False 92463.83204476784 80230.0608965113 93781.31092217288 96995.90828894556 103420.60896338389 97813.86262388703 73444.5555610132 87042.54453114203 75433.7564551486 90739.23103151876 1.0190061233012877 0.8841827287322168 1.0335255198448556 1.0689522843240042 1.1397562860926183 1.0779666249310715 0.8094024461756992 0.9592603281033684 0.8313246166803671 1.0 16.469438813188788 -7.249679844004874 24.94892531468953 0.896601872337842 1.03620843497987 0.41579048118576634 0.07964616877005058 763.6530884285247 1620162.35902535 0.03235584231986814 0.024841884227933302 5.627560284177149e-08 7.249679844004874 0.13960656264202786 HQEVQDQDPVFQGSDSSGYQS(ph)DHK ddPTM_A459_Selumetinib_30min_R2 2 HQEVQDQDPVFQGSDSSGYQSDHK 24 0 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 HQEVQDQDPVFQGSDS(0.001)SGYQS(0.998)DHK;HQEVQDQDPVFQGSDSSGYQS(1)DHK 167.17 6.3463e-16 10797200.0 48456.0 32379.0 48661.0 49678.0 51979.0 41889.0 45140.0 50578.0 34987.0 44993.0 True False 45763.00950473695 34862.365185105504 45530.20423809089 42911.77070067004 45448.933321844146 47658.82951951804 47239.09944321308 50725.17360636138 41985.3776184582 43693.93518414685 1.0473538103599513 0.7978765253845654 1.04202571927214 0.9820990148820332 1.0401657147679857 1.0907424409969313 1.0811363005901216 1.1609202373872156 0.9608971460572736 1.0 15.415145423875673 -5.894971158196455 1.3543316011800313 1.0683628631573425 0.931372511371599 0.22539932526458284 0.08109862988480751 0.5301887636125676 1.9713513816799282 0.027077401739549346 0.05574150442951801 1.2735876580648881e-06 5.894971158196455 -0.13699035178574348 HQGVMVGMGQK ddPTM_A459_Selumetinib_30min_R1 1 HQGVMVGMGQK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 156.48 0.00076968 70801000.0 8693.6 8643.3 9740.3 10060.0 10294.0 8523.0 8628.0 7910.8 5077.5 7904.2 False True 8896.143965199117 7631.338417838848 8417.620759638108 8303.209849587995 9362.909517553306 8437.26635826483 7977.183013557344 7700.97988610014 8616.146654072656 8918.781063427909 0.9974618618768862 0.8556481388619 0.9438084307456718 0.9309803425532994 1.0497969903024726 0.9460111531229796 0.8944252534988605 0.8634565453880858 0.9660677387186657 1.0 13.122630834055013 -2.8856974278281564 0.0029577868000231896 1.8546246807224476 3.586468244156965e-08 0.017721078491326647 0.058292214000546586 931319.3135840843 270.66890018038424 81976.31469160496 87830.36459713386 0.0013010757194190418 2.8856974278281564 -1.8546246448577652 HQGVMVGMGQK ddPTM_A459_Selumetinib_30min_R2 3 HQGVMVGMGQK 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;C9JUM1;C9JZR7;C9JTX5;P63261;I3L3I0;I3L1U9;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 ;; 143.5 0.0011718 367880000.0 1223330.0 1020070.0 1241070.0 1225620.0 1296750.0 948330.0 1088200.0 1050710.0 854950.0 1008740.0 False True 1155342.2159779968 1098306.0889579817 1161220.9073748498 1058688.441687574 1133840.6719079122 1078953.8494173768 1138803.4562273936 1053767.3921455962 1025963.8892989092 979615.0551787246 1.1793838915299357 1.1211608918746176 1.1853849134270322 1.0807188355168988 1.157434918863155 1.1014059489117676 1.1625009744461574 1.0756953831761427 1.047313313403221 1.0 19.9018554205159 -8.1996680780714 1.4699877276494013 1.0030903811911467 1.1398286580520423 0.6806493751719909 0.032831729258870006 0.2144850062095224 0.8627507412934077 0.028414677590969085 0.008863763131691104 6.314397559282881e-09 8.1996680780714 0.13673827686089557 HQHMHDRDDLYAEQMER ddPTM_A459_Selumetinib_30min_R1 1 HQHMHDRDDLYAEQMER 17 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 54.859 0.024737 689320.0 308.21 500.32 736.84 368.06 464.05 133.94 0.0 145.69 62.431 118.95 False True 315.39069332773755 441.7423018075424 636.781175172402 303.7852303418842 422.07675943468155 132.5926852077897 0.0 141.8258279321851 105.9408472201693 134.21839117111776 2.3498321696140696 3.2912203607354833 4.744366026266524 2.263365159507703 3.1447013762560103 0.9878876065407802 0.0 1.056679540670164 0.7893169206975753 1.0 7.068438559028641 -6.782140220675139 4.372028662482576 0.6867876629233074 3.2239493042117195 0.7518547472467585 0.6878501902309939 0.10172040013834002 4.508401850647257 0.24989596310192297 0.22970313116935256 1.651428515358411e-07 6.782140220675139 2.537161641288412 HQLGPSLRS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 HQLGPSLRSPPR 12 1 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;A0A0C4DGG3 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 HQLGPSLRS(1)PPR 101.61 0.006805199999999999 3385900.0 11191.0 10396.0 18768.0 19077.0 23782.0 12985.0 9286.1 7912.2 11793.0 17660.0 True False 10569.049021122484 11193.339771591362 17560.487313053363 16478.679690339435 20794.292546222467 14773.565883906082 9717.922050058069 7935.223192064779 14151.929523951112 17150.10991380956 0.6162671303122149 0.6526686900460209 1.0239285579687953 0.9608498005642823 1.2124874214058856 0.8614268921979419 0.5666390535627432 0.4626922644778622 0.8251801064292735 1.0 14.065930202104962 -7.136419270535362 6.345571370186964 0.6702086761455587 0.904351524830541 0.1275984176285999 0.21112886781267615 0.40901002182331825 19.431415698530614 0.0857560635762938 0.06629859252864798 7.304335779679458e-08 7.136419270535362 0.23414284868498236 HQNS(ph)LPELEAAEAGAPGSGPVDLFR ddPTM_A459_Selumetinib_30min_R1 2 HQNSLPELEAAEAGAPGSGPVDLFR 25 0 Q96BZ8 Q96BZ8 LENG1 Leukocyte receptor cluster member 1 1 HQNS(1)LPELEAAEAGAPGSGPVDLFR;HQNS(1)LPELEAAEAGAPGSGPVDLFR 123.41 5.0856e-08 8728400.0 1999.44 1786.02 2123.8 2188.0 2376.1 1676.62 2063.63 2171.98 795.12 1236.92 True False 2046.0230617670145 1576.911948101829 1835.3996251983417 1805.906873846773 2161.1821745345283 1659.7547250491582 1907.9687276619559 2114.3720348146553 1349.2605667328887 1395.6907306210933 1.465957333439134 1.1298433911645245 1.315047513700671 1.2939162195647242 1.5484678139065846 1.1891995043275485 1.3670426304349639 1.5149287649662495 0.9667332003648524 1.0 10.44676357661797 -8.277447078250082 24.839767818730113 0.9833664679253882 1.3438908848791726 0.5764536025341889 0.12655845405438707 609.7476996957529 946159.1888545993 0.1178539381949682 0.03082816989872955 5.279015312707569e-09 8.277447078250082 0.36052441695378445 HQNS(ph)LPELEAAEAGAPGSGPVDLFR ddPTM_A459_Selumetinib_30min_R2 1 HQNSLPELEAAEAGAPGSGPVDLFR 25 0 Q96BZ8 Q96BZ8 LENG1 Leukocyte receptor cluster member 1 1 HQNS(1)LPELEAAEAGAPGSGPVDLFR 56.21100000000001 0.0079679 2186200.0 6261.1 6076.2 8346.9 7504.9 11392.0 3307.7 4854.7 6138.0 4123.9 4868.5 True False 5913.133127169159 6542.22500193762 7809.8695414175745 6482.719673325387 9960.835114227837 3763.3056506889616 5080.453169405556 6155.860563799401 4948.795231393372 4727.933755117881 1.2506801984626637 1.3837387198701354 1.6518568038233545 1.3711528141247726 2.106805135212704 0.7959725845598552 1.0745609884880643 1.3020192081024444 1.0467141647313507 1.0 12.206994106168976 -6.78725991036223 24.999999389198315 1.0646488852839522 1.5388588450209357 0.5163611097874653 0.24570274497748612 202.3584968083987 195926.40859119693 0.08677245695793374 0.07655149796584665 1.6320749146650315e-07 6.78725991036223 0.47420995973698354 HQNVQLPR ddPTM_A459_Selumetinib_30min_R1 3 HQNVQLPR 8 0 A0A0U1RRM4;A0A087WUW5;A0A0D9SF20;K7EK45;A6NLN1;P26599;P26599-2;P26599-3 A0A0U1RRM4;A6NLN1 PTBP1 Polypyrimidine tract-binding protein 1 0 ;; 120.46 0.0070334 5752700.0 2693.34 3629.3 3640.7999999999997 4159.8 4022.3 3064.6099999999997 3812.5299999999997 3475.4600000000005 2393.03 3266.33 False True 2756.0895816726534 3204.379868784203 3146.3993574828723 3433.36901911691 3658.483675194742 3033.782805843245 3524.947792614488 3383.2795109149024 4060.7971300040344 3685.5952722484826 0.7478003899194382 0.8694334651751648 0.853701810715461 0.9315643106472469 0.9926439028023821 0.8231459457002221 0.9564120670428395 0.9179736951558586 1.1018022408973438 1.0 11.847681937079763 -2.165634556183811 0.2299793036042022 1.0160101948953333 4.42062423590521e-14 0.5553215835590434 0.06402228161909947 31.078696435360804 0.527031647459278 0.09527980653799674 11.184558593512147 0.006829131002383943 2.165634556183811 -1.016010194895289 HQNVQLPR ddPTM_A459_Selumetinib_30min_R2 3 HQNVQLPR 8 0 A0A0U1RRM4;A0A087WUW5;A0A0D9SF20;K7EK45;A6NLN1;P26599;P26599-2;P26599-3 A0A0U1RRM4;A6NLN1 PTBP1 Polypyrimidine tract-binding protein 1 0 ;; 163.67 0.0004605 6126900.0 19412.5 16674.5 22322.699999999997 22961.0 25324.5 19624.8 15696.24 26192.3 16901.2 18371.1 False True 18333.630964394644 17953.380533031966 20886.481785118085 19833.672190065703 22143.009906097497 22327.938063802856 16426.14626150951 26268.515256631297 20281.91225898436 17840.678609149865 1.0276308074398 1.0063171321198678 1.1707223835312035 1.111710637503088 1.24115289508893 1.2515184289207268 0.9207130861650694 1.4723943988968606 1.1368352461986773 1.0 14.122882871906057 -5.26544900023979 21.069827305216776 1.1754511401963466 1.0169739127277504 0.14164873956052038 0.14133519381707488 61.23297654383184 321796.258772644 0.03531337546765948 0.07864732297502004 5.426889762525424e-06 5.26544900023979 -0.15847722746859616 HQPASASSTAAS(ph)PAHPAK ddPTM_A459_Selumetinib_30min_R1 1 HQPASASSTAASPAHPAK 18 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91 Q96L91-3 EP400 E1A-binding protein p400 1 HQPASAS(0.001)S(0.006)T(0.002)AAS(0.99)PAHPAK 118.08 0.00066479 1609700.0 1509.4 1709.2 1491.1 2110.6 1931.2 1844.7 2128.6 1779.8 688.51 1045.8 True False 1544.566083218867 1509.0860694144767 1288.6168100260138 1742.0233308688287 1756.523300981052 1826.1439928535888 1968.0379882543082 1732.5939223948308 1168.351183219214 1180.0386169546452 1.3089114720711148 1.2788446477362005 1.0920124066376564 1.476242646502969 1.4885303546371687 1.5475290101660941 1.6677742236379283 1.4682518838800196 0.9900957192692614 1.0 10.204618357450348 -8.265324376326868 24.131693775770078 0.9950477271842731 1.4178407808094464 0.5546588212350831 0.15087529661457763 182.97104193540926 1136485.8915419271 0.14702640291495073 0.04363419748009335 5.428447270880096e-09 8.265324376326868 0.4227930536251733 HQPASASSTAAS(ph)PAHPAK ddPTM_A459_Selumetinib_30min_R2 3 HQPASASSTAASPAHPAK 18 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91 Q96L91-3 EP400 E1A-binding protein p400 1 HQPASASS(0.001)T(0.001)AAS(0.998)PAHPAK;HQPASAS(0.001)S(0.001)T(0.008)AAS(0.99)PAHPAK;HQPAS(0.002)AS(0.008)S(0.008)T(0.052)AAS(0.93)PAHPAK 143.47 0.00019372 6907900.0 31483.3 26029.8 29283.199999999997 38425.9 41083.2 26505.7 26517.8 29181.1 23496.399999999998 28703.5 True False 29733.58422363556 28026.201961001243 27399.15079313747 33192.226131625204 35921.961127532035 30156.61958021175 27750.93024402384 29266.012169808833 28196.336544269063 27874.75537435065 1.0666850282386815 1.005433109084428 0.9829378025089033 1.1907629568712736 1.2886915291312704 1.0818613177126135 0.9955578038743704 1.049910995693916 1.0115366454557058 1.0 14.766671523712086 -10.49356758162666 5.636076613032327 0.9999998784935172 1.0769202082526914 0.05647846374017462 0.09138045954272953 1.5600609321421696e-07 2.849707431994413e-08 0.0988848746917219 0.023983067008188298 3.2094633329097944e-11 10.49356758162666 0.07692032975917418 HQPS(ph)TPDPFLKPR ddPTM_A459_Selumetinib_30min_R2 2 HQPSTPDPFLKPR 13 1 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 HQPS(0.5)T(0.5)PDPFLKPR;HQPS(0.5)T(0.5)PDPFLKPR 62.799 0.036196 21087200.0 62793.0 56207.0 66773.0 69575.0 83743.0 54646.0 57318.0 70644.0 53876.0 72312.0 True False 59303.21644029526 60517.896166009596 62476.8978769455 60098.76497643055 73222.45566808131 62172.99047300206 59983.40057346229 70849.56234425626 64652.70542121516 70224.16467086044 0.844484469388116 0.8617816452449955 0.8896780498532626 0.8558131699837588 1.0426960008890644 0.8853503742537329 0.8541703679154256 1.0089057331806943 0.920661793903016 1.0 16.09967993788475 -1.522878745658199 0.14906438090975596 1.0043135912799461 0.4131678816873307 0.33796834942505594 0.056892655617009395 85.10041098250326 0.8358925457378158 0.20903514156344988 10.858309606928007 0.029999999973898264 1.522878745658199 -0.5911457095926154 HQPTAIIAK ddPTM_A459_Selumetinib_30min_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 109.44 0.016059999999999998 13312000.0 5540.5 6513.4 6556.2 6813.1 6359.0 5406.0 5859.7 6363.5 3881.2 5085.8 False True 5669.582870063694 5750.8081000024895 5665.904050628764 5623.319982726436 5783.829572772638 5351.620548255269 5417.698111328463 6194.719308438876 6586.112928367656 5738.611969887106 0.9879711156311601 1.002125275272031 0.9873300513016264 0.9799094297078013 1.0078795365713533 0.9325635844238044 0.9440781394102594 1.0794804285330941 1.1476839631129865 1.0 12.486486111054447 -7.775807130739907 23.716832313274306 1.0851867971661542 0.9782838263224103 0.5546394818028291 0.04009770679283448 89.6406287267328 147965.73312678238 0.021338684938233536 0.010338291515888427 1.6756868798051626e-08 7.775807130739907 -0.1069029708437439 HQPTAIIAK ddPTM_A459_Selumetinib_30min_R2 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 92.239 0.036751 17428000.0 144330.0 124860.0 154620.0 154520.0 154970.0 112960.0 120550.0 141490.0 100960.0 122330.0 False True 136308.71639876757 134436.3605118216 144671.91753752684 133474.10943813215 135501.28315062216 128519.21465121531 126155.81386529341 141901.71247506957 121154.8210580942 118798.01504848932 1.1473989388049202 1.1316381040284995 1.2177974310301116 1.123538212180166 1.140602249080636 1.08182964672228 1.0619353683123485 1.1944788169831801 1.0198387658972492 1.0 16.858151205326124 -8.753726832159273 0.23708983942774356 0.9599775730416091 1.1814871122433548 0.48956393004408727 0.04794800116430889 3.3535190450061148 0.5459274450882868 0.24831121156066874 0.12440494955413858 1.7630846642172085e-09 8.753726832159273 0.22150953920174565 HQPWQS(ph)PERPLSR ddPTM_A459_Selumetinib_30min_R1 2 HQPWQSPERPLSR 13 1 E7ES68;G5E9D5;Q9BQ52-2;Q9BQ52;J3QRS2;V9GYU5;J3QL08;V9GYS7 E7ES68 ELAC2 Zinc phosphodiesterase ELAC protein 2 1 HQPWQS(0.836)PERPLS(0.164)R;HQPWQS(1)PERPLSR 201.76 0.00042206 83911000.0 5582.299999999999 6976.0 4783.7 4993.9 5758.6 4827.5 6203.7 6112.299999999999 3211.73 5481.700000000001 True False 5712.356728735048 6159.246676945587 4134.099814983193 4121.80911211307 5237.735646763407 4778.939733019298 5735.749914372473 5950.181948451467 5450.071234521864 6185.329591279665 0.923533118879965 0.9957831003264804 0.6683717906983678 0.6663847174650431 0.8467997653912873 0.7726249123016574 0.9273151623898865 0.9619830052128963 0.8811286697164209 1.0 12.594634757314942 -7.322697506527854 6.439761486085621 0.940694953160049 0.809086954968025 0.29264541255841237 0.09925590516661476 0.3569348914041714 30.168666302797778 0.04595467347026611 0.030899874080421663 4.7566642031707285e-08 7.322697506527854 -0.13160799819202407 HQPWQSPERPLS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 HQPWQSPERPLSR 13 1 E7ES68;G5E9D5;Q9BQ52-2;Q9BQ52;J3QRS2;V9GYU5;J3QL08;V9GYS7 E7ES68 ELAC2 Zinc phosphodiesterase ELAC protein 2 1 HQPWQS(0.286)PERPLS(0.714)R;HQPWQS(0.01)PERPLS(0.99)R 97.291 0.0074182 312231000.0 3407.3999999999996 4056.8999999999996 2472.8 2750.7 3379.8999999999996 2969.4 4025.5 3343.5 1594.42 2913.5 True False 3486.7857903537642 3581.9162619983563 2137.007342118119 2270.341882033964 3074.188641769812 2939.530531999484 3721.8532940513564 3254.8195187813917 2705.6142881706596 3287.4761048932473 1.0606269609576338 1.0895641968824805 0.650044980992345 0.6906033107448815 0.9351212126512592 0.8941602731725218 1.1321309038601253 0.990066365482247 0.8230065259313931 1.0 11.682764692838191 -7.030443619141559 24.341784535746235 0.9894263702695362 0.8768687515297535 0.09781621527276041 0.14721276380934536 1251.216005833824 1000429.8946747403 0.06136071888258914 0.04760226224828737 9.323014954731864e-08 7.030443619141559 -0.11255761873978265 HQPWQSPERPLS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 HQPWQSPERPLSR 13 1 E7ES68;G5E9D5;Q9BQ52-2;Q9BQ52;J3QRS2;V9GYU5;J3QL08;V9GYS7 E7ES68 ELAC2 Zinc phosphodiesterase ELAC protein 2 1 HQPWQS(0.064)PERPLS(0.936)R;HQPWQS(0.388)PERPLS(0.612)R;HQPWQS(0.001)PERPLS(0.999)R 113.67 0.0024680999999999995 724990000.0 139668.0 113048.0 116350.0 131544.0 156175.0 124983.0 129725.0 141352.0 114865.0 109220.0 True False 131905.81169530304 121718.41809338806 108864.1676723015 113627.48027394322 136554.90027778537 142198.2737672878 135757.46954521097 141763.31091791668 137841.20959625603 106066.53481235988 1.2436138498222356 1.1475666505813318 1.0263762068299003 1.0712849295487898 1.2874456634164757 1.340651639264428 1.2799274510605698 1.336550790206423 1.2995730447884253 1.0 16.694610015930756 -6.270064192163391 23.97378533446651 1.2794787954085 1.1171762684910205 0.2655554259376156 0.10622423845913508 400.988890035183 1114597.915516563 0.03179729402483453 0.03666607084184027 5.369524246842837e-07 6.270064192163391 -0.1623025269174796 HQQIPLHS(ph)PPSK ddPTM_A459_Selumetinib_30min_R2 2 HQQIPLHSPPSK 12 0 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;C9JAU4 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 HQQIPLHS(0.987)PPS(0.013)K;HQQIPLHS(0.949)PPS(0.051)K 82.57799999999997 0.018801 26897000.0 69949.0 69416.0 79221.0 81144.0 89576.0 63402.0 64775.0 67401.0 52317.0 72782.0 True False 66061.51460803306 74739.98399238031 74124.00710930295 70092.0472187924 78322.66206039953 72135.04999394792 67787.16584922749 67597.12575116385 62781.86185911563 70680.59454965388 0.9346485414978242 1.0574328706286513 1.048717934273035 0.9916731411979279 1.1081211548861125 1.0205778609187033 0.9590633225588712 0.9563746058145585 0.8882475063931543 1.0 16.109026555124174 -7.287375150892305 3.631180375124051 0.9448701111026642 1.0319834441796925 0.3630504348055005 0.04924284592356356 0.24214048114890688 6.905093883062445 0.02102365448363872 0.014305041243552878 5.1597047272372186e-08 7.287375150892305 0.08711333307702829 HQQQLLAS(ph)PGSSTVDNK ddPTM_A459_Selumetinib_30min_R1 2 HQQQLLASPGSSTVDNK 17 0 F2Z2X4;Q9C0E2 F2Z2X4 XPO4 Exportin-4 1 HQQQLLAS(1)PGSSTVDNK;HQQQLLAS(0.982)PGS(0.017)STVDNK 299.23 4.355699999999998e-89 30573400.0 5229.1 7200.6 7019.4 7200.0 5967.6 6624.0 6032.1 5896.6 2834.85 4426.7 True False 5350.927855942614 6357.550404531881 6066.204034804242 5942.655160738922 5427.831633665351 6557.368574110784 5577.0938405284305 5740.203013143812 4810.533400747975 4994.910064709434 1.0712761164106948 1.2728057807186395 1.2144771289605047 1.1897421742836967 1.0866725453206134 1.3128101385529636 1.1165554070597392 1.1492104840285515 0.9630870903434006 1.0 12.286242986630574 -8.138655534184087 2.415129535418531 0.977136859452064 1.187341099895466 0.5265791690892461 0.07364663450139856 0.22610410219137536 2.3565879432365717 0.06162821004596064 0.019054865421334923 7.266821054407641e-09 8.138655534184087 0.21020424044340213 HQQQLLAS(ph)PGSSTVDNK ddPTM_A459_Selumetinib_30min_R2 3 HQQQLLASPGSSTVDNK 17 0 F2Z2X4;Q9C0E2 F2Z2X4 XPO4 Exportin-4 1 HQQQLLAS(0.998)PGS(0.002)STVDNK;HQQQLLAS(1)PGSSTVDNK;HQQQLLAS(0.999)PGS(0.001)STVDNK 237.66 1.9685e-22 80515000.0 253112.0 214526.0 276961.0 283820.0 282199.0 195765.0 233413.0 246396.0 184011.0 243861.0 True False 239045.04832761647 230979.45439018973 259141.63079233584 245163.2263831908 246746.63872893076 222729.851772266 244267.1669990852 247112.97156694662 220818.34169691883 236820.09930302997 1.0093951021519483 0.9753372077368877 1.0942552239231338 1.0352298099051345 1.0419159499346338 0.9405023155879417 1.031446096500982 1.0434628323111466 0.9324307453074934 1.0 17.853432004450354 HQS(ph)DGNEIAHTR ddPTM_A459_Selumetinib_30min_R2 1 HQSDGNEIAHTR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 HQS(1)DGNEIAHTR 86.22200000000002 0.019967 3940400.0 22013.0 20092.0 26427.0 30584.0 37368.0 21030.0 26857.0 28032.0 18102.0 27231.0 True False 20789.605585020938 21632.99179403748 24726.715591542026 26418.406439657243 32673.497765841443 23926.691608667294 28105.903716135886 28113.568479052585 21722.905812139677 26444.770275365117 0.7861518692937067 0.8180442321402922 0.9350323460580953 0.9990030605131619 1.2355372130526223 0.9047797110552492 1.062815196482089 1.0631050368867092 0.8214443001751413 1.0 14.69069482235048 -5.404880935447404 2.231062205539404 1.0213995163762004 0.7912353521346628 0.400991765852602 0.10192195907818749 0.3111039610294319 2.951569965204256 0.02874201502059769 0.08206905084809375 3.936579844654158e-06 5.404880935447404 -0.23016416424153763 HQS(ph)FGAAVLSR ddPTM_A459_Selumetinib_30min_R2 4 HQSFGAAVLSR 11 0 Q5VV41 Q5VV41 ARHGEF16 Rho guanine nucleotide exchange factor 16 1 HQS(1)FGAAVLSR;HQS(1)FGAAVLSR;HQS(1)FGAAVLSR;HQS(1)FGAAVLSR 139.21 0.00078536 24761800.0 76463.0 61011.799999999996 61867.6 70410.0 57176.399999999994 56537.9 67729.9 60351.1 52233.5 58643.1 True False 72213.492565641 65691.20887614251 57887.10597234975 60820.03653597514 49993.38946849862 64325.48252504376 70879.47455425079 60526.71170933758 62681.65952593072 56949.92132992776 1.2680174244190234 1.1534907747382808 1.0164562938900759 1.067956462724973 0.8778482621402075 1.1295095940938564 1.2445930196044521 1.0628058879781135 1.1006452346579603 1.0 15.797406228559193 -4.922589429593059 3.1316728616847174 1.0674473492290677 1.2723258068764802 0.33956066831641885 0.0893910646440015 0.3578304614700137 6.253405085588188 0.024595993800035923 0.15302679464562424 1.1951174026572066e-05 4.922589429593059 0.20487845764741253 HQSDPS(ph)EDEDER ddPTM_A459_Selumetinib_30min_R1 2 HQSDPSEDEDER 12 0 E5RJV7;E5RHR8;E5RHX2;E5RHY6;Q96BR1-2;Q96BR1 E5RJV7 SGK3 Serine/threonine-protein kinase Sgk3 1 HQS(0.001)DPS(0.999)EDEDER;HQS(0.273)DPS(0.727)EDEDER 126.48 0.0027282 554670.0 346.97 453.78999999999996 299.24 316.282 136.3 208.421 264.266 275.39 131.1 281.19 True False 355.05372591390665 400.66005583875256 258.60485160766166 261.0492860484483 123.97168906571946 206.32447397112693 244.33220285822267 268.0857626072101 222.46712483484475 317.28347552254394 1.1190426016645139 1.2627826116027416 0.8150593130693534 0.8227635732321648 0.3907284766770367 0.6502843352661994 0.7700754111314005 0.8449408282788486 0.7011620270121436 1.0 8.309628575819215 -5.380008702748316 3.4088484743909215 0.7206271373469257 1.193151518808887 0.5702189365341475 0.1530603128361318 0.16633853340636587 3.532388152470312 0.04237332518864423 0.10020968474859462 4.168610299841025e-06 5.380008702748316 0.4725243814619613 HRAEAPPLEREDS(ph)GTFSLGK ddPTM_A459_Selumetinib_30min_R2 1 HRAEAPPLEREDSGTFSLGK 20 2 G5E9Q4;O75569 G5E9Q4 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 1 HRAEAPPLEREDS(0.681)GT(0.159)FS(0.159)LGK 49.66 0.03052 4988700.0 16102.0 20176.0 19474.0 19436.0 18165.0 11052.0 8112.3 6837.2 6441.7 20032.0 True False 15207.11530141313 21723.434323934915 18221.06404168803 16788.783271029886 15882.950302839581 12574.312679933008 8489.538024217494 6857.095120040608 7730.219996136343 19453.624110613415 0.7817111719104568 1.1166780133313643 0.9366411080055295 0.8630157124229795 0.8164519995106844 0.6463737866237877 0.43639879006327736 0.3524841993991005 0.3973665756150252 1.0 14.247751326501751 -6.739801216999794 1.7336899730158908 0.4935626938461791 0.9419595065122505 0.44736117338448544 0.18793356071782927 0.2768166250116036 1.7212813430469034 0.07558322140170591 0.07011181860380238 1.8205339532207477e-07 6.739801216999794 0.44839681266607134 HRDLLHNEDR ddPTM_A459_Selumetinib_30min_R2 1 HRDLLHNEDR 10 1 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 108.43 0.008509200000000001 1253100.0 4776.6 4320.8 4129.7 2891.3 4656.6 3494.8 1983.5 2606.9 2290.2 5185.4 False True 4511.135694244813 4652.191466438246 3863.9995980773915 2497.4999522293006 4071.596277467812 3976.176977364265 2075.7366802306874 2614.485647404472 2748.3039935345405 5035.6840287128 0.8958337474160248 0.9238449910502862 0.7673236795727016 0.49596041729165063 0.8085487997761798 0.7896001724279429 0.4122055054278849 0.5191917587555182 0.5457657743941194 1.0 12.297972046569235 -5.497938186751086 4.540174093565455 0.6341998088334361 0.901394056681092 0.2679869790007182 0.16705324936841826 0.24514662766878975 12.341057119379586 0.04532654449845347 0.09211087392264766 3.1773262681596344e-06 5.497938186751086 0.2671942478476559 HRDYETATLSDIK ddPTM_A459_Selumetinib_30min_R2 2 HRDYETATLSDIK 13 1 O43707;O43707-2 O43707 ACTN4 Alpha-actinin-4 0 ; 96.745 0.011098 35920000.0 147546.0 151982.0 149428.0 177864.0 175773.0 121508.0 119849.0 129579.0 103079.0 160064.0 False True 139345.98399343554 163638.530700846 139813.96516490527 153638.61636748578 153690.8243094424 138244.62406019715 125422.2159762882 129956.05343704166 123697.68026790099 155442.5364237835 0.8964469263003798 1.0527268434086647 0.8994575640719732 0.9883949393917526 0.9887308059000955 0.8893616074515176 0.8068719081780112 0.8360391976797268 0.795777546569773 1.0 17.246021821750105 -6.92655552304128 4.367370086474841 0.8459769056460077 0.9671707972766005 0.3490270231632362 0.0676962098058786 0.2018580425205281 7.426788451596314 0.02314941963222551 0.02010895629957871 1.1842529546910567e-07 6.92655552304128 0.1211938916305928 HREDS(ph)DVEMVEDDSR ddPTM_A459_Selumetinib_30min_R2 1 HREDSDVEMVEDDSR 15 1 H0Y4N0;H0Y806;E7EUC9;A0A087WX20;A0A669KB03;A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692-2;P40692-3;P40692 H0Y4N0 MLH1 DNA mismatch repair protein Mlh1 1 HREDS(1)DVEMVEDDSR 68.625 0.031298 6271100.0 17200.0 19861.0 23387.0 30822.0 38351.0 19489.0 22802.0 30434.0 22253.0 29239.0 True False 16244.092857055393 21384.274836819553 21882.30588184032 26623.990429084337 33533.00451770993 22173.432846472504 23862.338181305826 30522.557901380093 26704.22180077031 28394.79409795456 0.5720799665254678 0.7531054728922998 0.7706449924007945 0.9376363264772614 1.1809560725120913 0.780897821268927 0.8403772219297327 1.074934996749239 0.9404618927204677 1.0 14.79333882978953 -5.330756230771698 1.4334780353083836 0.9642153965787832 0.5958324486803345 0.5652960118305527 0.11110239585329748 0.43257751422873736 1.4757958510930238 0.03556057890263288 0.16967542698919144 4.669213894662756e-06 5.330756230771698 -0.3683829478984487 HREDS(ph)DVEMVEDDSRK ddPTM_A459_Selumetinib_30min_R2 1 HREDSDVEMVEDDSRK 16 2 H0Y4N0;H0Y806;E7EUC9;A0A087WX20;A0A669KB03;A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692-2;P40692-3;P40692 H0Y4N0 MLH1 DNA mismatch repair protein Mlh1 1 HREDS(1)DVEMVEDDSRK 55.688 0.035488 16501000.0 22836.0 20641.0 26533.0 25400.0 27634.0 23638.0 20430.0 25347.0 12477.0 19882.0 True False 21566.866539750976 22224.098328724267 24825.89566694612 21940.476182556038 24162.36986890554 26893.919935600454 21380.035481277002 25420.755573578263 14972.74863650793 19307.955000360227 1.1169938266040398 1.151033256930091 1.285785867352754 1.1363438635602112 1.2514204569284912 1.3928932367564921 1.1073174492522961 1.316594925413074 0.7754704543401196 1.0 14.236907749064615 -8.259799816883739 24.999988791800426 0.8877352128274202 1.2199980955196565 0.62732880502869 0.10237522102733576 85.31169675115352 1300882.957181442 0.07503936527283253 0.024964521743091342 5.497942368792109e-09 8.259799816883739 0.33226288269223636 HRGS(ph)EEDPLLSPVETWK ddPTM_A459_Selumetinib_30min_R1 1 HRGSEEDPLLSPVETWK 17 1 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 HRGS(1)EEDPLLSPVETWK 126.09 0.00065794 5516200.0 1058.7 1632.3 1642.8 1986.2 1538.9 1601.0 1693.8 1369.6 856.53 954.31 True False 1083.3656501284052 1441.189557164317 1419.716783254466 1639.3474555916175 1399.7067667148626 1584.8953935916925 1566.0353023137966 1333.2737589122155 1453.4688515239482 1076.804984266577 1.0060927149833883 1.3383942108569695 1.318453019811614 1.5224181532816676 1.2998702524285002 1.4718499791038588 1.4543351165674991 1.2381756941999316 1.3497976632360416 1.0 10.072541277620457 -9.43758465703676 1.1759763394641605 0.9988725317255905 1.3456382554785657 0.34294779600203207 0.1373987127485967 10.21162587669793 11.970048465856173 0.16912488669336143 0.040332953877000456 3.6510295078838297e-10 9.43758465703676 0.3467657237529752 HRGS(ph)EEDPLLSPVETWK ddPTM_A459_Selumetinib_30min_R2 4 HRGSEEDPLLSPVETWK 17 1 Q13017-2;Q13017;A0A0A0MSK6;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 HRGS(1)EEDPLLSPVETWK;HRGS(1)EEDPLLSPVETWK;HRGS(0.999)EEDPLLS(0.001)PVETWK;HRGS(1)EEDPLLSPVETWK 130.73 0.00046102 10737200.0 96681.0 74336.0 87528.0 89481.0 89023.0 72106.0 68102.0 78383.0 65554.0 90768.0 True False 91307.85706470774 80037.33217208684 81896.54377328065 77293.53343666533 77839.13486428233 82037.9469869027 71268.8779415529 78611.08155299582 78666.6317317979 88147.29199641367 1.0358554981861798 0.9079953604853024 0.9290874616614729 0.8768679296445099 0.883057585790035 0.9306916313463205 0.8085203337211144 0.8918150492495466 0.8924452464744862 1.0 16.42762862824005 HRHS(ph)PTGPPGFPR ddPTM_A459_Selumetinib_30min_R1 3 HRHSPTGPPGFPR 13 1 P98175-5;P98175-2;P98175 P98175-5 RBM10 RNA-binding protein 10 1 HRHS(0.902)PT(0.098)GPPGFPR;HRHS(0.985)PT(0.015)GPPGFPR;HRHS(0.999)PT(0.001)GPPGFPR 88.311 0.010261 25053300.0 12451.9 15494.5 16826.3 14188.7 15552.4 11573.8 12088.599999999999 11576.9 6845.1 10876.3 True False 12742.00504282033 13680.39673680238 14541.380880249959 11710.909899885604 14145.68816599923 11457.3780801696 11176.747169412296 11269.843004929053 11615.63475367656 12272.379049133491 1.0382669074844129 1.1147306224841795 1.184886876622074 0.954249363794909 1.152644333210846 0.9335906293554845 0.9107237581780402 0.918309560013531 0.9464859834570298 1.0 13.583127327791388 -6.776662508984926 24.993548519980287 0.9347726436900277 1.0882333927865944 0.5745889823115551 0.06315357272935088 166.32288070196898 273069.57842171256 0.02161305797562297 0.019130911176313794 1.6723897265080028e-07 6.776662508984926 0.1534607490965667 HRHS(ph)PTGPPGFPR ddPTM_A459_Selumetinib_30min_R2 4 HRHSPTGPPGFPR 13 1 P98175-5;P98175-2;P98175 P98175-5 RBM10 RNA-binding protein 10 1 HRHS(0.998)PT(0.002)GPPGFPR;HRHS(0.997)PT(0.003)GPPGFPR;HRHS(0.993)PT(0.007)GPPGFPR;HRHS(0.903)PT(0.097)GPPGFPR 83.292 0.013411 82432000.0 92162.0 85497.0 117897.0 103905.0 118903.0 74212.0 67908.1 94126.0 67905.9 93730.0 True False 87040.00499371743 92054.34498381546 110311.63537654771 89752.95975387722 103965.34213369299 84434.02937053825 71065.96120734743 94399.89107660188 81488.97744937438 91023.7713602134 0.956233780396433 1.01132202729245 1.2118991965297217 0.9860386843200868 1.1421779231961857 0.9276041643715551 0.7807406806526854 1.037090527737287 0.8952494082770263 1.0 16.47395574183841 -6.820503033477002 10.573474387050597 0.9210028522987852 1.0628488829976777 0.3331645713213589 0.09408702310616489 0.554081808036031 96.23915339339867 0.03276089821739464 0.028913026819438088 1.5118091395806124e-07 6.820503033477002 0.14184603069889246 HRMS(ph)PGVAGSPR ddPTM_A459_Selumetinib_30min_R2 2 HRMSPGVAGSPR 12 1 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 HRMS(0.989)PGVAGS(0.011)PR;HRMS(1)PGVAGSPR 82.663 0.019747 22540000.0 10182.5 10068.4 16334.1 14075.0 13179.900000000001 12870.7 9234.4 14973.7 5102.0 16774.0 True False 9616.597413777117 10840.613904991387 15283.18178922341 12157.96071927072 11524.123132199036 14643.522096418177 9663.817897616456 15017.270987970529 6122.542561790778 16289.69103591401 0.5903486685275571 0.6654892275790254 0.9382118884592998 0.7463591968973488 0.7074488464386287 0.8989441275548744 0.593247464074706 0.9218880183093611 0.37585381750288327 1.0 13.99167162029552 -5.011049526078432 23.2245481618864 0.7672482997722163 0.6091335675718785 0.10275561110878051 0.17677394306468555 430.4396521350756 904763.6524714231 0.041020680603210596 0.12637834932814587 9.748784581788835e-06 5.011049526078432 -0.15811473220033778 HRPELIEYDK ddPTM_A459_Selumetinib_30min_R1 2 HRPELIEYDK 10 1 O43707;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 ; 94.616 0.018831 19601300.0 11709.699999999999 11966.3 10807.300000000001 9766.9 11968.5 10048.5 11215.2 11815.599999999999 7221.200000000001 12064.400000000001 False True 11982.513226890129 10565.280033018049 9339.728020249579 8061.294262419577 10885.951288210297 9947.421213308004 10369.22843459068 11502.21190552218 12253.848984419386 13612.983257207507 0.8802268393701203 0.7761179040181493 0.6860897309415688 0.5921769027484448 0.7996741847490807 0.7307304376534262 0.7617160940163946 0.8449442483103208 0.9001589697784639 1.0 13.732695644682744 -8.227052700206785 1.12164073629876 0.9961818203118316 0.7359941104031034 0.5856161277190751 0.0709295540966009 0.3437073439944748 0.8585484024775517 0.07063485652723796 0.023575944794930536 5.928533794075083e-09 8.227052700206785 -0.2601877099087282 HRPELIEYDK ddPTM_A459_Selumetinib_30min_R2 3 HRPELIEYDK 10 1 O43707;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 ;; 110.08 0.02047 55540600.0 192220.0 144567.0 175420.0 194026.0 194852.0 168658.0 199634.0 201306.0 170840.0 164544.0 False True 181537.18191762714 155654.82404382946 164133.6681828551 167599.32408648112 170372.9497610184 191889.10857511222 208917.3765672665 201891.76713199748 205012.77366843118 159793.18718334517 1.1360758560334185 0.9741017548215782 1.0271631167512147 1.048851500121712 1.0662090966715252 1.2008591352204552 1.3074235532179272 1.2634566635206343 1.2829882004493813 1.0 17.285846374402787 -6.777650210033237 3.4321786183455587 1.2377658731609156 1.0417695651439136 0.44383916760905506 0.08829710344530221 0.18375780271880734 4.5405533305822985 0.030274582998525142 0.02793327322338046 1.6685905896598038e-07 6.777650210033237 -0.19599630801700196 HRPS(ph)AGGPDSAGR ddPTM_A459_Selumetinib_30min_R2 1 HRPSAGGPDSAGR 13 1 Q01970-2;Q01970 Q01970-2 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 1 HRPS(0.999)AGGPDS(0.001)AGR 71.286 0.032075 5346700.0 0.0 884.64 666.74 0.0 751.97 739.81 622.35 880.45 0.0 735.7 True False 0.0 952.4890434340696 623.8426742916238 0.0 657.5008059029054 841.7121121734742 651.2905081631302 883.0119637336564 0.0 714.4584294218392 0.0 1.3331623005761886 0.8731686107986095 0.0 0.9202786038020077 1.1781120881373215 0.9115862887784438 1.2359179028067675 0.0 1.0 9.480706260701552 HRPS(ph)PPATPPPK ddPTM_A459_Selumetinib_30min_R1 1 HRPSPPATPPPK 12 1 A9Z1X7;Q8IYB3;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 HRPS(1)PPATPPPK 84.759 0.017702000000000002 10933000.0 3402.9 4340.0 4914.4 4638.9 4502.6 4076.1 4000.4 3927.6 2316.0 3415.9 True False 3482.1809491092404 3831.87078238874 4247.051472866902 3828.803197937749 4095.340624998597 4035.0981348026853 3698.6466072594817 3823.4272893571965 3930.082846052634 3854.3640386836614 0.9034385216759316 0.99416421073122 1.1018812520670338 0.9933683376844077 1.0625204531529495 1.0468907696068968 0.9595997083146925 0.9919735787756492 1.019644954812009 1.0 11.912277123031792 -4.8099531076988 4.0664000226940145 1.0222162952011238 0.8966565038838946 0.457834937784254 0.038565152027774344 0.19267654016648947 5.7968832699014365 0.009961976034366823 0.06572109129317726 1.548983859113525e-05 4.8099531076988 -0.12555979131722916 HRPS(ph)PPATPPPK ddPTM_A459_Selumetinib_30min_R2 2 HRPSPPATPPPK 12 1 A9Z1X7;Q8IYB3;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 HRPS(1)PPATPPPK;HRPS(1)PPATPPPK 118.08 0.0025348 17976500.0 63325.0 64755.0 72253.0 66267.0 69877.0 44091.0 54448.0 52537.0 43813.0 64299.0 True False 59805.65001006005 69721.5002798575 67604.32064311822 57241.32028304885 61098.42655169396 50164.13503175226 56979.939886665234 52689.87397203147 52576.8242375028 62442.52080113477 0.9577712309297609 1.1165708780704837 1.0826648215952492 0.9167041872852866 0.9784746958931808 0.8033649889233911 0.9125182512751748 0.8438140116065579 0.8420035508327415 1.0 15.93024115956046 -6.0448828603963385 1.7105004974957667 0.8789934419025323 1.057658841708754 0.47885755999297575 0.07053184767893994 0.2762054299597181 1.6198821557751597 0.02286907499871522 0.03655417218014533 9.018143456920416e-07 6.0448828603963385 0.17866539980622176 HRPT(ph)DSPEMNGGCNSNGQFR ddPTM_A459_Selumetinib_30min_R2 1 HRPTDSPEMNGGCNSNGQFR 20 1 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 HRPT(0.943)DS(0.057)PEMNGGCNSNGQFR 67.252 0.020372 1738000.0 4980.5 4838.0 6231.3 4915.5 7162.4 3954.0 4153.0 6053.2 4817.1 5715.1 True False 4703.703748521182 5209.059043378127 5830.3849421264595 4246.000420289537 6262.595279331587 4498.6276091616965 4346.12272901338 6070.813809838796 5780.65460101967 5550.090213386921 0.847500413088018 0.938553941125818 1.0505027338228596 0.7650326854234017 1.128377204432838 0.8105503579583125 0.7830724478190374 1.093822546378774 1.0415424576480978 1.0 12.438295506457834 -7.785383646918906 24.99978395738786 1.0507619254664065 0.9101455821331902 0.25247999295549806 0.11121925046391262 341.656659545069 356712.4084058538 0.05954572369582016 0.028628325150778205 1.6391411494730914e-08 7.785383646918906 -0.14061634333321626 HRS(ph)EDCGGGPR ddPTM_A459_Selumetinib_30min_R2 2 HRSEDCGGGPR 11 1 Q9UGU0-2;Q9UGU0;A9JX13 Q9UGU0-2 TCF20 Transcription factor 20 1 HRS(1)EDCGGGPR;HRS(1)EDCGGGPR 67.964 0.040317 2240130.0 0.0 0.0 0.0 0.0 0.0 440.51 1519.62 5982.5 472.88 857.5799999999999 True False 0.0 0.0 0.0 0.0 0.0 501.18625394836135 1590.2853410699054 5999.90808454381 567.4692133711526 832.8194371395692 0.0 0.0 0.0 0.0 0.0 0.6017946166935695 1.9095199633331745 7.204332436273707 0.681383248354772 1.0 9.701859929806902 -7.367443144334978 3.5760898962862355 3.3897150819340798 0.06869902094378157 0.3584460063347855 1.6874815579270526 0.21925720602985785 5.164564251819174 0.716825069918584 0.46267498006000757 4.29098360976759e-08 7.367443144334978 -3.3210160609902983 HRS(ph)NSFSDER ddPTM_A459_Selumetinib_30min_R1 1 HRSNSFSDER 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 HRS(0.778)NS(0.22)FS(0.002)DER 85.807 0.019768 4481100.0 1079.1 825.52 2177.3 2157.4 2173.4 1281.8 1116.4 961.09 657.94 649.35 True False 1104.2409304369153 728.8677346261641 1881.6346190528066 1780.6505894136328 1976.8163537449357 1268.906255781281 1032.1890491812037 935.598771139706 1116.4761259636753 732.7003977046268 1.5070838420399868 0.9947691265209224 2.5680818857851215 2.4302574353610025 2.6979872809375065 1.731821437188321 1.4087464022331673 1.2769186069377207 1.5237826121854514 1.0 9.517079588537017 -7.138650967531893 3.6144266055528282 1.3230010784942046 2.0442098299390543 0.3291568204436195 0.49152121421330636 0.34321428107658863 8.105257625917975 0.22200269287483945 0.1680141557162283 7.266897466197724e-08 7.138650967531893 0.7212087514448497 HRS(ph)NSFSDER ddPTM_A459_Selumetinib_30min_R2 1 HRSNSFSDER 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 HRS(0.994)NS(0.006)FS(0.001)DER 79.986 0.02678 10646000.0 20271.0 20738.0 21863.0 29532.0 29430.0 20498.0 23677.0 21844.0 25847.0 47731.0 True False 19144.41897124243 22328.537916820096 20456.35838263458 25509.690654458467 25732.740292461815 23321.41343768247 24778.02741508543 21907.562423531122 31017.1222255206 46352.882009968474 0.4130146420480458 0.4817076511449322 0.441317939588639 0.5503366683644925 0.5551486590828987 0.5031275818549331 0.5345520351842796 0.4726256809408262 0.6691519681311332 1.0 15.500371421360951 -14.522878745276472 0.205487753689163 3.3209277474145105 0.4378002949321874 0.9055899946153347 0.049441825120822305 40.134232008185556 0.39779578297476537 38.195665996483584 0.1118059436447127 3.000000000026702e-15 14.522878745276472 -2.883127452482323 HRS(ph)PSGAGEGASCSDGPR ddPTM_A459_Selumetinib_30min_R1 1 HRSPSGAGEGASCSDGPR 18 1 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 HRS(0.998)PS(0.002)GAGEGASCSDGPR 68.458 0.015133 379780.0 195.37 256.81 232.12 308.49 271.06 310.89 119.57 213.11 136.83 0.0 True False 199.92174087615615 226.74256581227016 200.59937894389262 254.61801257449292 246.5426708595299 307.762728865535 110.5507386336407 207.45763052116106 232.19051633220303 0.0 0.0 HRS(ph)PSGAGEGASCSDGPR ddPTM_A459_Selumetinib_30min_R2 3 HRSPSGAGEGASCSDGPR 18 1 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 HRS(0.917)PS(0.083)GAGEGASCSDGPR;HRS(0.99)PS(0.01)GAGEGASCSDGPR;HRS(0.997)PS(0.003)GAGEGASCSDGPR 73.672 0.0095728 2711670.0 3308.6099999999997 3312.05 5537.3 7252.400000000001 6489.299999999999 2012.21 5203.46 4745.87 2557.4 3866.96 True False 3124.7307016152354 3566.0735850807237 5181.036146556392 6264.610608912178 5674.0561189219325 2289.3736624762937 5445.431200460385 4759.679695978926 3068.9514597263283 3755.310817231314 0.8320831094133008 0.949608103999735 1.3796557458794383 1.6682002938789766 1.5109418088341502 0.6096362655180124 1.4500613838604044 1.2674529293658054 0.8172296806017726 1.0 11.874716605429779 -8.25649816658751 24.478963040824745 0.9086148344406797 1.219034090113309 0.12742807186244565 0.31286856113012185 617.8281659759134 3060797.3455407256 0.23974396342021376 0.08410299129276062 5.539898826508465e-09 8.25649816658751 0.3104192556726293 HRSNS(ph)FSDER ddPTM_A459_Selumetinib_30min_R1 1 HRSNSFSDER 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 HRS(0.001)NS(0.988)FS(0.011)DER 84.821 0.020531 4119000.0 2007.5 1601.4 3403.3 3505.9 3502.2 2270.5 2042.7 2175.5 1503.2 1209.5 True False 2054.270844084986 1413.9073435293371 2941.1505529887545 2893.6603788936904 3185.4266283636307 2247.660831449057 1888.6174944127958 2117.798672980084 2550.820610615856 1364.7511065276747 1.5052347891562814 1.036018462829263 2.155082006470689 2.1202843251440973 2.3340714751045604 1.646938273725062 1.3838548914739408 1.551783810872579 1.8690738541373222 1.0 10.414422151470793 -10.289626313685813 0.507458190159126 0.8220035018630096 1.7616026329990795 0.25251715105599404 0.3760728640615977 22.509545991049425 4.182441612471896 6.9088421802679285 0.2002219379898104 5.133028626739252e-11 10.289626313685813 0.9395991311360699 HRSNS(ph)FSDER ddPTM_A459_Selumetinib_30min_R2 1 HRSNSFSDER 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 HRS(0.017)NS(0.982)FS(0.001)DER 77.74 0.029838 8983800.0 6341.0 8998.1 10025.0 22962.0 20100.0 8008.4 3555.8 4720.2 4021.1 16500.0 True False 5988.592605034201 9688.225336548308 9380.002414394708 19834.535988340624 17574.858303720102 9111.48440698294 3721.151745684033 4733.935000528825 4825.432358921381 16023.602127851515 0.3737357279125831 0.6046221854016622 0.5853866277727157 1.2378325316668413 1.0968107023309237 0.5686289720802391 0.23222941483401488 0.29543513142407035 0.3011452930757703 1.0 13.967910883589674 -6.995434487037713 24.94441604106124 0.39876590572307113 0.7894222555741822 0.18821314230234887 0.30879770034486687 183.3250746341047 1001617.2768006553 0.1140774865998799 0.10023273462646752 1.0105679323650064e-07 6.995434487037713 0.3906563498511111 HS(ph)AGSGAEESNSSSTVQK ddPTM_A459_Selumetinib_30min_R1 1 HSAGSGAEESNSSSTVQK 18 0 Q8IYL3 Q8IYL3 C1orf174 UPF0688 protein C1orf174 1 HS(0.572)AGS(0.428)GAEESNSSSTVQK 148.66 0.000125 8491800.0 5929.2 6987.3 6716.2 7201.3 7521.2 6479.6 7121.9 5903.7 2371.2 4187.2 True False 6067.338823785155 6169.223667692361 5804.176929445852 5943.7281401429445 6840.908787975712 6414.421107006076 6584.689349125411 5747.114698079763 4023.7532144041515 4724.667906781876 1.2841831306441633 1.3057475762131225 1.2284835768275753 1.2580203005614865 1.4479131492302653 1.3576448617264079 1.3936830014388157 1.2164060652454003 0.8516478393387992 1.0 12.20599721165154 -8.118914184218147 4.158730125840817 0.93067473240248 1.3232430901360832 0.8329518637128588 0.07032709410589713 0.0916789179929435 2.5754960088221948 0.05555578932605483 0.019369044990172484 7.60476530842785e-09 8.118914184218147 0.3925683577336032 HS(ph)FNSFR ddPTM_A459_Selumetinib_30min_R1 1 HSFNSFR 7 0 P51828 P51828 ADCY7 Adenylate cyclase type 7 1 HS(0.998)FNS(0.002)FR 91.853 0.02779 2778000.0 344.49 533.42 285.65 253.65 348.6 338.71 467.07 287.74 189.92 316.81 True False 352.51594673914656 470.96693841976975 246.86029896313522 209.35478910019825 317.0691915503289 335.30288492407385 431.83853385978574 280.10820048875655 322.2803687920194 357.47564949072586 0.9861257605695798 1.3174797754496792 0.6905653554719665 0.5856476920832328 0.8869672437886005 0.9379740561399351 1.2080222372488874 0.7835728136666369 0.9015449562820654 1.0 8.481701161580578 -5.259625324709586 24.998649743050603 0.8708952549237673 1.1518027593083164 0.28269833448934933 0.17675632033154476 209.03850859546247 2880607.520493587 0.04844872656956632 0.1153924183011096 5.500151792830342e-06 5.259625324709586 0.28090750438454914 HS(ph)FNSFR ddPTM_A459_Selumetinib_30min_R2 1 HSFNSFR 7 0 P51828 P51828 ADCY7 Adenylate cyclase type 7 1 HS(0.991)FNS(0.009)FR 84.743 0.037131 1579800.0 947.8 1261.9 2139.4 1158.1 2017.5 2093.4 1156.3 2485.7 1167.3 1251.5 True False 895.1250703440172 1358.683672351976 2001.753333202598 1000.3647821660685 1764.0436133211597 2381.7468480068537 1210.0702411649822 2492.9329754702117 1400.7926170870978 1215.3659432124946 0.7365066261261145 1.1179214622064029 1.647037539912875 0.8230975927479686 1.4514505883375195 1.9596952352567518 0.9956427098545195 2.0511788975103338 1.1525685945950381 1.0 10.247175055257465 -6.43888862212629 10.493436216156757 1.4962517003716278 1.1251701672413041 0.141550036966976 0.40650110350309615 1.0734606538329798 129.90199578446502 0.12048314606683576 0.13656937623101406 3.6400837666556786e-07 6.43888862212629 -0.37108153313032366 HS(ph)LEEGLDMVNR ddPTM_A459_Selumetinib_30min_R1 2 HSLEEGLDMVNR 12 0 Q7Z309-2;Q7Z309;Q7Z309-5 Q7Z309-2 FAM122B Protein FAM122B 1 HS(1)LEEGLDMVNR;HS(1)LEEGLDMVNR 206.67 6.6712e-06 2683000.0 3288.9 3690.2 3497.0 3989.0 3757.7000000000003 3198.3 3436.1000000000004 2977.5 1636.74 2617.7 True False 3365.5249709146237 3258.149668472562 3022.126607646012 3292.3960328038265 3417.8166984758195 3166.1280058240545 3176.9122105800207 2898.527027716941 2777.428237240152 2953.7072935572514 1.1394239971765807 1.1030712743877409 1.0231638775575358 1.1146656406968074 1.1571277580317125 1.071916642766243 1.0755677170549813 0.9813183026088361 0.9403193888908334 1.0 11.52831114967591 -7.719660389533239 2.7114312145811703 0.9651959418248203 1.1002335514037953 0.707507951199865 0.03685423525069726 0.15552977822297362 2.3014786464036727 0.02341461279838181 0.01094274664097514 1.9069513366854957e-08 7.719660389533239 0.13503760957897504 HS(ph)PATISSSTR ddPTM_A459_Selumetinib_30min_R2 1 HSPATISSSTR 11 0 O15119;O15119-2;O15119-3 O15119 TBX3 T-box transcription factor TBX3 1 HS(1)PATISSSTR 84.734 0.023725 16297000.0 17806.0 12824.0 13503.0 17437.0 18320.0 16402.0 16853.0 15401.0 15254.0 13937.0 True False 16816.413803065592 13807.559564340863 12634.231680954783 15062.050519497221 16018.477817122013 18661.226617468437 17636.69789358596 15445.814360227205 18305.226232370933 13534.602597325247 1.2424756236573142 1.0201673425616176 0.933476368449237 1.1128550255678606 1.183520365813152 1.378779057846614 1.3030820644169767 1.1412093003218031 1.352476077575301 1.0 13.72436490734724 -6.288738630195926 3.125987081890277 1.2494874046564706 1.0585799156503246 0.25233898298657575 0.12569579637597925 0.3069674693655303 6.123310478551631 0.03964011673651555 0.048362819395535016 5.143531096380519e-07 6.288738630195926 -0.19090748900614596 HS(ph)PEDFR ddPTM_A459_Selumetinib_30min_R2 1 HSPEDFR 7 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 HS(1)PEDFR 83.78299999999999 0.025567 3445300.0 14762.0 8161.8 8968.1 9864.5 10602.0 8032.3 16786.0 17508.0 12657.0 9192.9 True False 13941.587136968123 8787.783815676641 8391.102209728997 8520.93808278835 9270.081976917434 9138.67641504034 17566.582260827978 17558.945381394573 15188.753666128152 8927.477090977343 1.5616491641360073 0.9843524353098722 0.9399186493807483 0.9544620496870425 1.0383764508660962 1.0236572238618733 1.9676983857602777 1.96684295041661 1.7013489378179238 1.0 13.124036811342284 -7.251346367856307 24.497965569041096 1.739542814261059 1.064743484672041 0.4501698684498605 0.3058769819777906 403.74875287873533 979988.9388205587 0.11382951433468481 0.0870769905629944 5.606006953951982e-08 7.251346367856307 -0.674799329589018 HS(ph)PIAPSSPSPQVLAQK ddPTM_A459_Selumetinib_30min_R2 1 HSPIAPSSPSPQVLAQK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 HS(1)PIAPSSPSPQVLAQK 193.54 1.1467e-20 0.0 9157.1 10013.0 9084.1 8677.7 9835.8 8747.3 8767.7 10592.0 8627.5 7088.7 True False 8648.185040775697 10780.964903130474 8499.638896020244 7495.782290132541 8600.138870832352 9952.161174916571 9175.415422867958 10622.820966400002 10353.241072491157 6884.030812345515 1.256267625250373 1.566083185420433 1.2346892580401252 1.088865302097419 1.249288259344982 1.4456880636078513 1.3328550776404393 1.5431106071386995 1.5039504259516263 1.0 12.74903783943686 -6.75658021820925 24.965779130048777 1.3970486404461757 1.2819565841679468 0.040287680591266195 0.1785692725631169 325.94536019983576 1674666.8374144342 0.06036431273807209 0.0585490060509417 1.751538878890073e-07 6.75658021820925 -0.11509205627822894 HS(ph)PIKEEPCGSLSETVCK ddPTM_A459_Selumetinib_30min_R2 4 HSPIKEEPCGSLSETVCK 18 1 J3QQY0;J3KSZ8;Q68DK7;Q68DK7-2;J3KTC2;Q68DK7-3 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 HS(0.999)PIKEEPCGS(0.001)LSETVCK;HS(0.901)PIKEEPCGS(0.072)LS(0.025)ET(0.002)VCK;HS(0.987)PIKEEPCGS(0.013)LSETVCK;HS(0.629)PIKEEPCGS(0.369)LS(0.002)ETVCK 78.22800000000002 0.0056122 44892900.0 249724.6 231227.5 237090.9 255617.0 249492.7 238382.1 305778.0 297378.1 212417.5 243645.1 True False 235845.90645877988 248961.90573640328 221836.7296190538 220801.52363607925 218149.1965329624 271217.0704577501 319997.2828876121 298243.42103740544 254906.9354408448 236610.43289700572 0.9967688388509959 1.0522017253768943 0.9375610656847799 0.9331859163293618 0.9219762368970462 1.1462599815951833 1.3524225410081723 1.26048296935084 1.0773275392797381 1.0 17.8521541624718 -6.8694317357050805 5.166459599183845 1.2009940851479075 0.9700044387271449 0.5018599240708271 0.0974442570933416 0.15983884961335024 6.647874308055506 0.035057950062674134 0.03095763450004935 1.3507291246463363e-07 6.8694317357050805 -0.23098964642076258 HS(ph)PPMVR ddPTM_A459_Selumetinib_30min_R2 1 HSPPMVR 7 0 C9K0K7;I3L0S1;E7EPA1;O60256-4;O60256-3;O60256-2;O60256;I3L4G9 C9K0K7 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 1 HS(1)PPMVR 69.812 0.045415 4198200.0 13167.0 10197.0 12363.0 13718.0 19656.0 11675.0 19448.0 19904.0 14597.0 11181.0 True False 12435.230851677226 10979.077111477225 11567.578039816643 11849.58473513006 17186.637553130462 13283.125274902079 20352.370535480906 19961.917344715428 17516.80787425715 10858.175478273191 1.1452412863063104 1.0111346177307554 1.0653334957574538 1.0913053264648966 1.5828292319939283 1.223329398339631 1.8743821718672027 1.838422798071231 1.6132367642526717 1.0 13.406494084019139 -6.37490038117816 1.4244745836210344 1.6092762765618414 1.0490815953616568 0.38963843081712857 0.2567465388812801 0.3687036248279032 1.513181249024083 0.09910835810658114 0.12483059779286844 4.217932436106094e-07 6.37490038117816 -0.5601946812001846 HS(ph)PQQPSNGSLR ddPTM_A459_Selumetinib_30min_R2 2 HSPQQPSNGSLR 12 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 HS(1)PQQPSNGSLR;HS(1)PQQPSNGSLR 92.265 0.01449 113401080.0 28265.9 21974.0 33683.9 38388.4 47016.8 33261.6 35436.6 33168.9 42167.9 41603.4 True False 26694.994435362885 23659.33514245369 31516.714546257335 33159.833696316295 41110.129248475016 37843.08348125766 37084.47211629077 33265.41600759302 50602.65826956826 40402.20174338528 0.6607311800707355 0.5855951933690653 0.7800741837396846 0.8207432334240369 1.01752200312216 0.9366589405601736 0.9178824548185003 0.8233565145503312 1.2524727882646398 1.0 15.302146295242126 -5.74246131666215 1.3565896312847183 0.9792271187994037 0.6130470851407006 0.640422761832081 0.10862548813061694 0.2933696681114098 1.0733440145092543 0.03594116809046912 0.08995888901559242 1.8094170708893315e-06 5.74246131666215 -0.3661800336587031 HS(ph)PTEDEESAK ddPTM_A459_Selumetinib_30min_R1 1 HSPTEDEESAK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HS(0.739)PT(0.261)EDEESAK 123.28 0.0039093 10778000.0 2079.4 2071.7 763.85 718.79 1403.3 1395.4 1597.6 1962.4 1381.0 2434.9 True False 2127.84597419194 1829.1444008927995 660.1233655277111 593.2668198593792 1276.3717627727374 1381.363542921829 1477.0917457648607 1910.350777226439 2343.4561357507287 2747.443132934466 0.7744822626844502 0.6657624243305601 0.2402682543688 0.21593415810784325 0.4645671269670579 0.502781486671367 0.5376241378969765 0.6953194969993965 0.852958923028827 1.0 11.423873904987644 -8.111702090457992 1.2099250669502792 0.9932832147580809 0.4596678219278503 0.5648475110280466 0.15834437983767963 0.3665388502877824 0.9986568797938498 0.16355260403967162 0.05477138242546783 7.732107965013462e-09 8.111702090457992 -0.5336153928302306 HS(ph)PTEDEESAK ddPTM_A459_Selumetinib_30min_R2 2 HSPTEDEESAK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HS(0.593)PT(0.407)EDEESAK;HS(0.529)PT(0.471)EDEESAK 139.46 0.0011664000000000002 37322000.0 80073.0 38055.4 51831.7 68200.0 65592.0 64384.0 138472.0 150152.0 105058.0 67930.0 True False 75622.8632176161 40974.12681260273 48496.90485208802 58911.04234843783 57351.74656008006 73252.31158023942 144911.2223770626 150588.91746099837 126072.53556578112 65968.68439666368 1.1463448742270306 0.6211148090543847 0.7351504019768009 0.8930152675807678 0.8693783586046561 1.1104103750164238 2.196666853407666 2.2827333732399597 1.9110967077608894 1.0 16.009493713304856 -7.123663525076941 4.14789531143036 1.95027698768692 0.8467732229700586 0.6360972960113971 0.3526938049764295 0.13181920677608847 3.8048549412049004 0.13434757529108268 0.10301418954499496 7.522054486230398e-08 7.123663525076941 -1.1035037647168613 HS(ph)PTEDEESAKAEADAYIR ddPTM_A459_Selumetinib_30min_R1 1 HSPTEDEESAKAEADAYIR 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HS(0.5)PT(0.5)EDEESAKAEADAYIR 144.08 3.6466e-05 20510000.0 2914.1 3429.4 2802.5 2305.3 2974.5 3108.5 3300.6 3923.3 2130.5 3786.6 True False 2981.9928601484703 3027.884253715194 2421.9358930305843 1902.7226308404772 2705.457000190629 3077.2313122921764 3051.6330846716937 3819.241339325564 3615.3028944365915 4272.6469946074385 0.6979263355741958 0.7086670762964329 0.5668467102682108 0.4453264295510318 0.6332039608245709 0.7202166048765528 0.7142254177616822 0.893881789004773 0.8461506178721319 1.0 12.060914411377588 -7.700686610816882 0.9681471370412481 0.9630942656137458 0.6063885812692881 0.7341837349266944 0.07845586319850502 0.31459429421975066 0.5359113382423821 0.07527952143729935 0.031991116850532304 1.9921103377528163e-08 7.700686610816882 -0.3567056843444577 HS(ph)PTGPPGFPR ddPTM_A459_Selumetinib_30min_R1 1 HSPTGPPGFPR 11 0 P98175-5;P98175-2;P98175 P98175-5 RBM10 RNA-binding protein 10 1 HS(0.656)PT(0.344)GPPGFPR 73.881 0.037348 4480600.0 1043.5 1336.2 1065.8 1118.7 1114.8 1239.2 1196.8 945.98 659.63 1175.1 True False 1067.811519702456 1179.757082817473 921.0702140203373 923.3400455998096 1013.966536833925 1226.734773103577 1106.5244124507917 920.8895374239024 1119.3439325309585 1325.9355314432992 0.805326876292491 0.8897544826582112 0.6946568608940886 0.6963687326447472 0.7647178258585532 0.9251843276032126 0.8345235391997713 0.6945205974090621 0.8441918222920968 1.0 10.372794916275408 HS(ph)PTPQQSNR ddPTM_A459_Selumetinib_30min_R2 2 HSPTPQQSNR 10 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 HS(0.988)PT(0.012)PQQSNR;HS(0.965)PT(0.035)PQQSNR 81.709 0.029389 1887340.0 829.64 867.24 2833.0 1112.2 1102.9 3330.0099999999998 5753.49 26382.3 3669.8999999999996 7159.16 True False 783.5319301120603 933.754519383888 2650.727864337177 960.7164413479857 964.3438419489004 3788.6886506789438 6021.038685324151 26459.068125175112 4403.982545573495 6952.456449068449 0.11269857436029604 0.13430569845698215 0.38126493617839846 0.1381837410109503 0.13870548474677777 0.544942449971993 0.8660304065811016 3.8057150474808554 0.6334426656011027 1.0 12.763307087066158 -7.534127655252216 24.994429752697606 1.9989222110730032 0.273072149735348 0.4346110668894463 0.793329979323654 175.69806355851372 390385.65776462946 0.3453442876103777 0.19959856264268488 2.9232929873391493e-08 7.534127655252216 -1.7258500613376553 HS(ph)PVQMNR ddPTM_A459_Selumetinib_30min_R2 2 HSPVQMNR 8 0 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 HS(1)PVQMNR;HS(1)PVQMNR 89.82700000000001 0.029123000000000007 54026000.0 203483.0 190222.0 215477.0 214137.0 267590.0 177957.0 195178.0 219800.0 179439.0 212894.0 True False 192174.22946698844 204811.41573986702 201613.4444136187 184971.1711930712 233972.9519150476 202468.9614171947 204254.1637378697 220439.58161015133 215331.8139445658 206747.1970549589 0.9295131068495377 0.9906369646473258 0.9751689371635084 0.8946731749108112 1.1316862102505378 0.979306923147176 0.9879416342634794 1.066227667171481 1.0415222891139118 1.0 17.65750824483785 -6.241732445282818 24.99994078352793 1.0326765320381392 0.9525558959710447 0.44185259550696054 0.04771481035963521 855.9700534728158 1085871.561116971 0.014014122570340173 0.018067799276423137 5.731490207281545e-07 6.241732445282818 -0.08012063606709452 HS(ph)QPSPEPHSPTEPPAWGSSIVK ddPTM_A459_Selumetinib_30min_R2 1 HSQPSPEPHSPTEPPAWGSSIVK 23 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 HS(0.52)QPS(0.458)PEPHS(0.017)PT(0.004)EPPAWGSSIVK 51.56800000000001 0.019282 7287900.0 22923.0 25903.0 27901.0 24211.0 34387.0 24806.0 18870.0 25449.0 21438.0 28384.0 True False 21649.031428039565 27889.676808727523 26105.8800363119 20913.420033695438 30066.99763631957 28222.801333552125 19747.492390195646 25523.052376691237 25726.19902776768 27564.48016951134 0.7853959623002518 1.0117976699439404 0.9470840689093505 0.7587090307920068 1.090787762055322 1.0238829522629251 0.7164108399199218 0.9259399132410233 0.9333097838073162 1.0 14.750522773870197 -4.737231084044368 24.36406106601411 0.9277056348804216 0.7853951034213519 0.13835410568863393 0.11034455228436606 3578.886633436104 3601656.133726887 0.027732578070539936 1.6901268039276178 1.831339724288827e-05 4.737231084044368 -0.1423105314590697 HS(ph)S(ph)ISPVRLPLNSSLGAELSR ddPTM_A459_Selumetinib_30min_R1 1 HSSISPVRLPLNSSLGAELSR 21 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 2 HS(0.667)S(0.667)IS(0.667)PVRLPLNSSLGAELSR 103.4 0.00014209 18586000.0 1037.7 1085.1 1029.8 1332.8 1009.6 800.84 872.81 655.23 413.54 602.69 True False 1061.876390987292 958.0559875506963 889.9588162864922 1100.05149975456 918.2818582593568 792.784276704542 806.9732389966375 637.8511719130044 701.7471762334231 680.0511321977388 1.561465514446831 1.4087999301677832 1.3086645608696943 1.6176011591944492 1.350312961455886 1.1657715709442034 1.1866361230643367 0.9379459009966564 1.0319035481428709 1.0 9.409499414659422 -7.006306403986648 1.231094934932468 0.9973044378797018 1.4644791128341585 0.8161823621702398 0.09480272476612948 0.19300889751748904 0.5978809160274717 0.054422260111755334 0.03910098470718382 9.85583889901236e-08 7.006306403986648 0.46717467495445675 HS(ph)SEDFR ddPTM_A459_Selumetinib_30min_R2 1 HSSEDFR 7 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 HS(0.649)S(0.351)EDFR 101.25 0.020043 17926000.0 100420.0 78483.0 73111.0 68926.0 85665.0 80103.0 131010.0 189180.0 108390.0 135120.0 True False 94839.05841311067 84502.39373738038 68407.11785723791 59538.15989601796 74902.99684518317 91136.46114736461 137102.22459139008 189730.48247956482 130071.02866963964 131218.7345160783 0.7227554720967836 0.6439811666300308 0.5213212740506651 0.4537321603930171 0.5708254779427496 0.6945384855559449 1.0448372718804944 1.44591001566409 0.9912534909693248 1.0 17.00161418725788 -7.257567412419676 2.941139319627602 1.1758285271960434 0.5799444021693175 0.7787021257651784 0.136701661867433 0.11407926053997967 1.996898245921426 0.06056758710433585 0.041369346677574595 5.526276208618511e-08 7.257567412419676 -0.5958841250267258 HS(ph)SETFSSTPSATR ddPTM_A459_Selumetinib_30min_R2 2 HSSETFSSTPSATR 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 HS(0.5)S(0.5)ETFSSTPSATR;HS(0.954)S(0.046)ETFSSTPSATR 261.02 7.544799999999998e-36 107423000.0 49373.0 37574.0 54897.0 64501.0 64251.0 47623.0 52060.0 52149.0 40701.0 57617.0 True False 46629.046315778796 40455.804980547706 51364.98678733427 55715.85252956878 56179.214968772125 54182.635971448566 54480.89315493296 52300.74495626829 48842.33728095772 55953.447503055795 0.8333543042764655 0.7230261366529432 0.9179950312182116 0.9957537026923312 1.0040349160917028 0.9683520567430538 0.9736825090528619 0.9347189009830356 0.8729102398612755 1.0 15.771939403375512 -5.409453689484723 4.734584232122941 0.9633396768452054 0.7801226409763897 0.7325792509690913 0.04421597680801917 0.10806970612066857 3.7209583921760854 0.011963215349377929 0.025796531220349767 3.895348431094088e-06 5.409453689484723 -0.18321703586881566 HS(ph)SGEQDTSTLPSPPLLTTVEDVNQDNK ddPTM_A459_Selumetinib_30min_R1 1 HSSGEQDTSTLPSPPLLTTVEDVNQDNK 28 0 O15063;A0A0J9YXL1 O15063 KIAA0355 Uncharacterized protein KIAA0355 1 HS(0.471)S(0.471)GEQDT(0.022)S(0.016)T(0.016)LPS(0.004)PPLLTTVEDVNQDNK 102.56 1.9771e-07 8927300.0 998.72 1018.6 831.32 961.29 732.42 901.76 974.03 896.3 401.63 856.09 True False 1021.988232829169 899.3418384657077 718.4313101138928 793.4187471481548 666.1727403192533 892.6891131325705 900.5581329039475 872.527212407286 681.5367761054056 965.9774905227597 1.0579834860086623 0.9310173863150883 0.7437350426510436 0.8213635979434459 0.6896358837085732 0.9241303466082552 0.9322765196284137 0.903258327412059 0.7055410532771081 1.0 9.91584576114473 -4.9317484865863035 3.690144857554477 0.83648242617509 1.0540886970487928 0.3210653567526497 0.09810278273794068 0.27904806153484396 7.166400153302742 0.025032025640363685 0.13157903179732428 1.1701768805737185e-05 4.9317484865863035 0.21760627087370277 HS(ph)SNPPLESHVGWVMDSR ddPTM_A459_Selumetinib_30min_R1 2 HSSNPPLESHVGWVMDSR 18 0 Q6PKG0;Q6PKG0-3;H0YC33;H0YBR8 Q6PKG0 LARP1 La-related protein 1 1 HS(0.815)S(0.185)NPPLESHVGWVMDSR;HS(0.854)S(0.146)NPPLESHVGWVMDSR 212.37 7.4336e-12 50059000.0 2169.4900000000002 2586.2 2625.4 2791.7 2258.8 2019.0700000000002 2336.6400000000003 2043.99 916.32 1586.71 True False 2220.0348959073153 2283.406501708238 2268.8851002899173 2304.1820016992842 2054.4919388235294 1998.7599889688813 2160.3853635603436 1989.776745384769 1554.9281146351252 1790.3796843642222 1.239979941291429 1.2753755651104215 1.2672647707659932 1.2869795283214003 1.1475174549654787 1.1163888902585803 1.2066632471466594 1.11137138270833 0.8684907051921181 1.0 10.806049855762135 -7.6336698315062215 0.7214105724372287 0.9456863537423466 1.2606090639239613 0.7304977793574774 0.06645670403483055 0.3672224734057662 0.3657990273694394 0.06245358440890441 0.03205681073072686 2.3245033076246843e-08 7.6336698315062215 0.3149227101816148 HS(ph)SNPPLESHVGWVMDSR ddPTM_A459_Selumetinib_30min_R2 2 HSSNPPLESHVGWVMDSR 18 0 Q6PKG0;Q6PKG0-3;H0YC33;H0YBR8 Q6PKG0 LARP1 La-related protein 1 1 HS(0.5)S(0.5)NPPLESHVGWVMDSR;HS(0.5)S(0.5)NPPLESHVGWVMDSR 82.406 0.0050153 7237300.0 21115.4 25356.9 24389.0 27338.0 25981.0 22184.0 21192.3 21195.0 19769.8 24465.0 True False 19941.890599643455 27301.69269471576 22819.838292735418 23614.51723931956 22717.034506913024 25239.644633698303 22177.783941745798 21256.67394097886 23724.31241436521 23758.63188229619 0.8393534904887856 1.1491273079179147 0.9604862100557096 0.9939342196263407 0.9561592022409625 1.0623357758451442 0.9334621644721738 0.8946926761729209 0.9985554947733941 1.0 14.536164141889536 HS(ph)SPAPAQPK ddPTM_A459_Selumetinib_30min_R2 2 HSSPAPAQPK 10 0 Q70CQ4;I3L4X5 Q70CQ4 USP31 Ubiquitin carboxyl-terminal hydrolase 31 1 HS(0.5)S(0.5)PAPAQPK;HS(0.5)S(0.5)PAPAQPK 91.961 0.018056 9194900.0 39398.0 28338.0 31335.0 28562.0 30172.0 27294.0 47140.0 69876.0 33226.0 57323.0 True False 37208.41688268999 30511.433478968473 29318.940214968414 24671.806327801783 26381.52361889764 31053.50074973683 49332.10340613791 70079.32759140547 39872.12841200713 55667.93604695951 0.668399432867464 0.5480970850658106 0.5266755388638082 0.4431959953929227 0.47390877931316 0.5578345984219927 0.8861852425159625 1.2588813699198227 0.7162494470492387 1.0 15.76455897415942 -7.318330001206025 3.713158100505163 1.0022556325378524 0.526710292321821 0.712109738155627 0.13446407714423225 0.11919167162297199 3.3431159963908708 0.05678927711491676 0.03776996831664767 4.804741186327949e-08 7.318330001206025 -0.47554534021603145 HS(ph)SPHISR ddPTM_A459_Selumetinib_30min_R2 1 HSSPHISR 8 0 O60583-2;O60583 O60583-2 CCNT2 Cyclin-T2 1 HS(0.654)S(0.346)PHISR 96.015 0.014169 1686900.0 1251.2 702.23 2262.8 3072.7 3968.0 2246.5 2444.2 6463.8 4949.2 7757.9 True False 1181.6633129504473 756.0887829746641 2117.213911550358 2654.1929592968486 3469.504365629918 2555.934983303428 2557.8601430904178 6482.608587860303 5939.178292202057 7533.909269555099 0.15684597075327247 0.1003580951034354 0.2810246096413882 0.35229956511721927 0.4605184694286613 0.3392574680494346 0.3395130006976401 0.8604574804287657 0.7883262300758745 1.0 12.87918294375691 -7.733781600358866 0.5272649214547168 1.0399859339402868 0.17360643365197778 0.8536225104229932 0.11174855705426669 0.32368608210196387 0.2021542009474453 0.12070180669743802 0.07883204237002776 1.84594348080102e-08 7.733781600358866 -0.866379500288309 down HS(ph)SPSGTVAAR ddPTM_A459_Selumetinib_30min_R2 1 HSSPSGTVAAR 11 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 HS(0.5)S(0.5)PSGTVAAR 126.66 0.0031164 5912100.0 31754.0 33537.0 32989.0 37566.0 37928.0 26181.0 31893.0 34279.0 29990.0 36799.0 True False 29989.239801333515 36109.18006154863 30866.52365570742 32449.445995035447 33163.14555937791 29787.19510254488 33376.0876947806 34378.74621480605 35988.837990612556 35736.517254715596 0.8391763413200625 1.0104280672953339 0.8637250081115401 0.908019261187339 0.9279904172811323 0.8335226091069163 0.9339490879004578 0.9620060614683883 1.0070605855097328 1.0 15.125111421198612 -7.843036596406594 2.3199466543330622 1.0005176473374255 0.902063254660129 0.4318401409052782 0.04812499157102848 0.2990464125814474 3.145180074514926 0.03300308992171515 0.013115241818251829 1.435368475009026e-08 7.843036596406594 -0.0984543926772965 HS(ph)SPTEERDEPAYPR ddPTM_A459_Selumetinib_30min_R2 1 HSSPTEERDEPAYPR 15 1 F5H4R1;J3KNB8;F5H538;Q9Y6R4-2;Q9Y6R4 F5H4R1 MAP3K4 Mitogen-activated protein kinase kinase kinase 4 1 HS(0.435)S(0.435)PT(0.13)EERDEPAYPR 64.53699999999999 0.037733 9244100.0 7515.8 5064.3 8940.1 11374.0 10248.0 9258.3 5756.0 7231.3 6366.1 6455.0 True False 7098.101924131211 5452.715525708941 8364.903699244902 9824.841578755606 8960.554621717592 10533.54678652042 6023.665405297623 7252.341885793843 7639.497883695852 6268.627377895845 1.1323215588089064 0.8698420239390945 1.3344075496879673 1.5673034918935405 1.4294284987035442 1.68035937558888 0.9609225500526645 1.1569266202305672 1.2186875089487548 1.0 12.613933859763685 -7.318081850347582 24.999887279491638 1.097211447576046 1.3291828600553581 0.2367882255615239 0.22049915816439494 542.1295544897215 239273.66299958195 0.10347189556482667 0.06976076050884361 4.807487344517815e-08 7.318081850347582 0.2319714124793122 HS(ph)SSENNSHYVR ddPTM_A459_Selumetinib_30min_R2 1 HSSSENNSHYVR 12 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8;Q4KWH8-3;Q4KWH8-4 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 HS(0.955)S(0.022)S(0.022)ENNSHYVR 99.991 0.009167299999999998 510230.0 0.0 0.0 676.3 590.9 1866.2 1191.1 1089.8 3136.0 743.03 2460.7 True False 0.0 0.0 632.7875942997645 510.4184006406439 1631.751271960321 1355.1632132707375 1140.4778593977321 3145.1252408072505 891.6567619928264 2389.6531973335864 0.0 0.0 0.2648031082526281 0.21359517825020677 0.6828402019929316 0.5670961856652884 0.4772566415370631 1.316142963471282 0.373132286721668 1.0 11.222585544378186 -6.318845764618671 0.7119652621858531 0.8525542455327874 4.36852624062417e-19 0.6039281117159031 0.2522771881364438 0.529362754667618 0.5834133650426289 0.15070792129943614 0.2536888136214661 4.799038514733952e-07 6.318845764618671 -0.8525542455327874 HS(ph)SYPAGTEDDEGMGEEPSPFR ddPTM_A459_Selumetinib_30min_R2 1 HSSYPAGTEDDEGMGEEPSPFR 22 0 Q92934 Q92934 BAD Bcl2-associated agonist of cell death 1 HS(0.578)S(0.421)YPAGTEDDEGMGEEPSPFR 162.2 1.4445e-09 9299900.0 28160.0 28557.0 30035.0 35778.0 30425.0 26979.0 25016.0 31125.0 28157.0 36239.0 True False 26594.979933411618 30747.23007477246 28102.580799635423 30904.97467950748 26602.73949704895 30695.112359022118 26179.293568263616 31215.56859697888 33789.18677231337 35192.685909770364 0.7556962262442206 0.8736823939384594 0.7985346975700268 0.8781647061194465 0.7559167142074646 0.8722014692973574 0.7438845001880233 0.886990230782944 0.960119578793861 1.0 15.102988004487665 -8.157909935258147 2.6974669014947015 0.9889211185994632 0.8157795107070475 0.6483856646805258 0.04940987336123022 0.16297636807556626 2.125536518184924 0.039018051654193184 0.012045142211009385 6.951684678821099e-09 8.157909935258147 -0.17314160789241573 HS(ph)VTGYGDCAVGAR ddPTM_A459_Selumetinib_30min_R1 1 HSVTGYGDCAVGAR 14 0 Q96IF1;H0YJL9 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 HS(0.965)VT(0.035)GYGDCAVGAR 79.332 0.023983 3120100.0 1481.9 2073.1 1289.4 1578.6 1958.9 1387.9 1503.4 1547.3 759.37 1359.0 True False 1516.425386724552 1830.3804882419577 1114.3065621672197 1302.9271439920078 1781.717840871884 1373.9389861123743 1389.9973276057165 1506.2605776612663 1288.5954278095815 1533.440887780992 0.9889037124338959 1.1936426782584755 0.7266706992401304 0.8496754940957943 1.1619083950801443 0.8959843167483102 0.9064564136001033 0.9822749541007364 0.8403293782483386 1.0 10.58255683825826 HS(ph)VTGYGDCAVGAR ddPTM_A459_Selumetinib_30min_R2 1 HSVTGYGDCAVGAR 14 0 Q96IF1;H0YJL9 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 HS(0.689)VT(0.311)GYGDCAVGAR 122.5 0.0011673 9167800.0 21385.0 14305.0 18185.0 24535.0 24301.0 21499.0 24391.0 26150.0 20758.0 20419.0 True False 20196.507310937755 15402.14750217531 17014.99689833095 21193.290674764252 21248.091126303592 24460.29210150919 25525.2298298496 26226.09217063444 24910.180026980197 19829.450415066673 1.0185106943555122 0.7767309320117395 0.8580669933949726 1.068778520390122 1.0715421094151465 1.2335335367098195 1.2872383901499962 1.3225829068216393 1.2562214032948247 1.0 14.275357072524915 -6.2449902646963515 1.3813940653318044 1.244530331533834 0.8744212936903565 0.631810188404053 0.10634472446507084 0.23946062085668465 0.9211748942397974 0.03963835316975405 0.05639240516001132 5.688656826017263e-07 6.2449902646963515 -0.3701090378434776 HS(ph)YPPALGSPGALAGAGVGAAGPLER ddPTM_A459_Selumetinib_30min_R1 4 HSYPPALGSPGALAGAGVGAAGPLER 26 0 Q96IF1;H0YJL9 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 HS(0.999)Y(0.001)PPALGSPGALAGAGVGAAGPLER;HS(0.554)Y(0.443)PPALGS(0.003)PGALAGAGVGAAGPLER;HS(1)YPPALGSPGALAGAGVGAAGPLER;HS(1)YPPALGSPGALAGAGVGAAGPLER 177.79 1.3657e-21 150509000.0 9415.0 12271.5 8705.2 9158.0 10001.699999999999 8830.900000000001 10137.499999999998 9633.1 5300.43 9017.5 True False 9634.351181599071 10834.747075134426 7523.081654240795 7558.727216950972 9097.048000943552 8742.06916381567 9372.820213251918 9377.598895281295 8994.442581909658 10174.983962888224 0.9468664733761712 1.0648416857119964 0.739370369691013 0.7428736246190001 0.8940601807456123 0.8591727707582731 0.9211631435919623 0.9216327936716878 0.8839760941850701 1.0 13.312738900165801 -7.302621936422598 7.507874794204468 0.9253931533089723 0.8719528727660754 0.08249489296889623 0.09220750058241119 0.9180057750020921 146.44424021032566 0.04221545241582269 0.028596255442477844 4.9817056548698824e-08 7.302621936422598 -0.053440280542896956 HS(ph)YPPALGSPGALAGAGVGAAGPLER ddPTM_A459_Selumetinib_30min_R2 4 HSYPPALGSPGALAGAGVGAAGPLER 26 0 Q96IF1;H0YJL9 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 HS(0.826)Y(0.174)PPALGSPGALAGAGVGAAGPLER;HS(0.972)Y(0.028)PPALGSPGALAGAGVGAAGPLER;HS(1)YPPALGSPGALAGAGVGAAGPLER;HS(0.999)Y(0.001)PPALGSPGALAGAGVGAAGPLER 191.59 5.8423e-28 107757800.0 107719.4 100834.8 135889.4 125000.1 137234.4 97756.1 119566.4 110007.0 93623.4 109616.9 True False 101732.78698292392 108568.50492501551 127146.42394919196 107974.87074280009 119993.78778089782 111221.1154334779 125126.47451632685 110327.10215736082 112350.69605636246 106451.97527808996 0.9556683820771023 1.0198824835461853 1.194401734839028 1.0143059389995517 1.127210532894593 1.0448008610730732 1.1754265168819324 1.0364025831286612 1.0554120368632238 1.0 16.69984319451791 -5.0068506900498395 19.319839694083523 1.0852104078509421 0.9717202509435962 0.28383682567322166 0.06266953061395213 17.443153717806176 49225.7287883939 0.014592510535446584 0.04813813205416476 9.843494658234794e-06 5.0068506900498395 -0.11349015690734598 HSADGIPPTVLRS(ph)PVGLSSDGISSSSSSSR ddPTM_A459_Selumetinib_30min_R2 2 HSADGIPPTVLRSPVGLSSDGISSSSSSSR 30 1 O60583-2;O60583 O60583-2 CCNT2 Cyclin-T2 1 HS(0.003)ADGIPPT(0.091)VLRS(0.637)PVGLS(0.132)S(0.132)DGIS(0.002)S(0.003)S(0.001)SSSSR;HS(0.004)ADGIPPT(0.242)VLRS(0.727)PVGLS(0.011)S(0.014)DGIS(0.001)S(0.001)SSSSSR 58.168 0.0016142 8549300.0 19868.2 19162.2 23453.4 27920.0 26674.0 16430.4 15913.7 14040.0 13875.0 21991.6 True False 18764.00498270626 20631.879123815703 21944.433778131148 24117.247835313563 23322.973651414417 18693.538459678894 16653.718582398324 14080.854075552872 16650.387699891602 21356.645366961166 0.8786026391454843 0.9660636663346632 1.027522506511219 1.1292619894612785 1.0920710275732335 0.8753031264263014 0.7797909407702067 0.6593195623005484 0.7796349760833615 1.0 14.382397430482573 -6.970490335799963 4.018532264094161 0.7802096707298882 1.0217659692896242 0.4928988111643079 0.10183260128141826 0.17122790888148048 6.151025961716355 0.03951132194820345 0.03330283890584881 1.0703101998771031e-07 6.970490335799963 0.24155629855973593 HSAGS(ph)GAEESNSSSTVQK ddPTM_A459_Selumetinib_30min_R1 1 HSAGSGAEESNSSSTVQK 18 0 Q8IYL3 Q8IYL3 C1orf174 UPF0688 protein C1orf174 1 HSAGS(0.998)GAEESNS(0.001)SSTVQK 218.64 2.8048e-14 3956100.0 1342.8 1513.7 1793.2 1577.2 1671.9 1477.8 1755.0 1549.2 568.71 993.79 True False 1374.084627366036 1336.4753002999619 1549.6932893425305 1301.7716277107538 1520.6769401979202 1462.9346737350436 1622.6189370413933 1508.1101834891977 965.0593330650231 1121.352626834344 1.2253813782424285 1.1918421273715871 1.3819856950060587 1.1608940814503153 1.3561094911695142 1.3046160848305224 1.4470193391548551 1.3449027071410151 0.8606207449564304 1.0 10.131024312125046 -8.258870874615305 24.99865844442747 0.9303103453075482 1.3026906577327837 0.7342113261406187 0.08935396455644366 107.51702076461459 1046465.2697990219 0.06841132572531333 0.0231520045653959 5.5097148810197e-09 8.258870874615305 0.3723803124252355 HSAGS(ph)GAEESNSSSTVQK ddPTM_A459_Selumetinib_30min_R2 3 HSAGSGAEESNSSSTVQK 18 0 Q8IYL3 Q8IYL3 C1orf174 UPF0688 protein C1orf174 1 HS(0.082)AGS(0.918)GAEESNSSSTVQK;HS(0.221)AGS(0.779)GAEESNSSSTVQK;HS(0.216)AGS(0.784)GAEESNSSSTVQK 86.35700000000001 0.004820399999999999 20142500.0 112467.0 101302.0 126719.0 145508.0 154636.0 100598.0 101389.0 115109.0 92175.0 127787.0 True False 106216.53438107266 109071.53766273087 118566.03750121556 125689.55938469918 135209.2432166199 114454.46136227837 106103.78939849204 115443.94813267933 110612.57558468526 124097.45727950044 0.8559122540427626 0.878918392478202 0.9554268080946522 1.0128294498541812 1.0895408026942308 0.9222949758309432 0.8550037343595053 0.9302684411387164 0.8913363578075283 1.0 16.9211140298097 -5.207457740418822 4.04828901830695 0.9566543204693468 0.8623242780118954 0.24945376251715534 0.0626525440934539 0.3543217157979805 12.079561655327044 0.018365927085568674 0.052857578209115144 6.2021499153227765e-06 5.207457740418822 -0.09433004245745147 HSAIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 HSAISPK 7 0 A0A0C4DGZ1;Q8N5P1 A0A0C4DGZ1 ZC3H8 Zinc finger CCCH domain-containing protein 8 1 HSAIS(1)PK 83.647 0.025734 2555600.0 4249.5 6796.7 6741.3 4222.2 2875.7 4245.6 2363.5 4960.5 9514.7 4661.2 True False 4348.505081912399 6000.939204299894 5825.868487310288 3484.8720305099805 2615.593442746072 4202.893118696371 2185.2192921352334 4828.931426025151 16145.750973807 5259.510423932864 0.8267889463865252 1.1409691626416851 1.1076826582185806 0.6625848700009086 0.49730739782244404 0.7991034868134372 0.4154796009513769 0.9181332551508203 3.0698201300899437 1.0 12.360712798659476 -8.093885688681194 9.791142050557823 2.030696733324541 0.7818951138923038 0.48656195295579174 0.5107985801296435 0.34534161638975946 33.97767465592204 0.3216108498586926 0.121318729544523 8.05590453998648e-09 8.093885688681194 -1.248801619432237 HSAS(ph)PVVFTSAR ddPTM_A459_Selumetinib_30min_R1 2 HSASPVVFTSAR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 HS(0.001)AS(0.999)PVVFTSAR;HS(0.106)AS(0.894)PVVFTSAR 88.22399999999998 0.027441000000000004 21411600.0 4547.9 4866.3 6049.9 5860.3 4771.9 4285.2 4707.6 4356.6 2700.8 3409.8999999999996 True False 4653.8572213270745 4296.551333718506 5228.356809721936 4836.90861645532 4340.28248754737 4242.094778650293 4352.501941889494 4241.048815768809 4583.060341372606 3847.593880238709 1.209550011301698 1.1166852499131075 1.3588639998038365 1.2571255613274945 1.128051094435698 1.1025318447556915 1.1312269634911314 1.102259996189018 1.1911497117487533 1.0 11.909740813009583 -6.312482389447962 6.024821084027209 1.1143280366971597 1.2358137762017791 0.4325199592800886 0.07081396117145965 0.22444112107758193 19.377401946170885 0.022264527370080205 0.02553125538008471 4.869872719993488e-07 6.312482389447962 0.12148573950461938 HSAS(ph)PVVFTSAR ddPTM_A459_Selumetinib_30min_R2 1 HSASPVVFTSAR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 HS(0.394)AS(0.606)PVVFTSAR 113.67 0.0038744 8095300.0 58660.0 51892.0 60904.0 58306.0 61855.0 48165.0 53975.0 53214.0 46905.0 49868.0 True False 55399.91203458538 55871.949540921414 56985.50294726142 50364.622216539865 54084.22190928391 54799.29155166241 56484.944449433475 53368.84392994804 56287.31063520116 48428.18126737571 1.1439602021954574 1.1537073678742567 1.1767012812775288 1.0399858284677865 1.1167923406142544 1.131557909414589 1.1663651818261718 1.102020404922798 1.1622842147309764 1.0 15.563559202728356 -11.479796922673794 2.4225935301154484 0.8966827813468653 1.1313898393873054 0.524783751866982 0.037838238513039024 11836525.011636559 4975250.697256098 6872751.936600215 0.010254892582837426 3.312859955370771e-12 11.479796922673794 0.23470705804044012 HSCSGS(ph)SPPR ddPTM_A459_Selumetinib_30min_R1 2 HSCSGSSPPR 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HSCS(0.001)GS(0.5)S(0.5)PPR;HSCSGS(0.5)S(0.5)PPR 85.554 0.024013 1222010.0 124.09 59.636 128.79 0.0 59.159 0.0 0.0 0.0 0.0 0.0 True False 126.98105556289202 52.65378939597575 111.30102539283102 0.0 53.80807889536976 0.0 0.0 0.0 0.0 0.0 0.0 HSCSGS(ph)SPPR ddPTM_A459_Selumetinib_30min_R2 1 HSCSGSSPPR 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HSCS(0.009)GS(0.751)S(0.24)PPR 128.91 0.0030386 81255000.0 2479.3 2682.2 3731.7 2502.2 2955.7 3445.6 6050.7 17158.0 5637.5 11431.0 True False 2341.5104314242685 2887.9161153676746 3491.6064847677544 2161.39604346424 2584.3785417067406 3920.200123957398 6332.069539234596 17207.926939340196 6765.1575249109155 11100.957328695185 0.21092869399395225 0.26015018613778623 0.3145320156976191 0.1947035719052072 0.23280681703246492 0.3531407254241001 0.5704075199772768 1.5501299959832229 0.6094210908660521 1.0 13.438396477188432 -7.551132159764692 6.1743718984551546 1.0661866655164056 0.27384460882021283 0.7277660340513392 0.21655150694462033 0.08307215370199414 9.973702989753551 0.09569400357053248 0.0556566674511686 2.811045273559968e-08 7.551132159764692 -0.7923420566961927 HSCSGSS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 HSCSGSSPPR 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HS(0.002)CS(0.006)GS(0.032)S(0.961)PPR 102.95 0.014737 21598000.0 1299.4 838.43 2480.6 971.12 998.83 2834.1 5033.9 15778.0 4458.9 7201.3 True False 1227.1845499103354 902.7348850226387 2321.00089667307 838.8517807245601 873.3480457465055 3224.4715496017125 5267.986324483617 15823.911367811486 5350.804592075436 6993.37975777558 0.17547803671692386 0.12908420767783046 0.3318854369509204 0.11994941069686424 0.12488211365548604 0.46107485383109476 0.7532818904373687 2.262698711623331 0.7651242714405936 1.0 12.771774133877454 -7.418218973214714 3.092144604990741 1.398759342720188 0.20995216368757358 0.6218326272629423 0.38517652706712724 0.14958462382959 2.728155153981823 0.17157805248704674 0.10550964448479451 3.8175174137641694e-08 7.418218973214714 -1.1888071790326145 HSCSPMGDGDPEAMEES(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 HSCSPMGDGDPEAMEESPR 19 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 HSCSPMGDGDPEAMEES(1)PR 125.79 0.00025261 17669000.0 1757.5 1616.9 1624.7 1864.7 2228.0 1440.1 1536.9 1414.8 848.72 1135.4 True False 1798.446330500305 1427.592596323584 1404.0746638382832 1539.0651497541473 2026.4777933853484 1425.6139015061822 1420.9703956347107 1377.2749080819235 1440.2158519437792 1281.139649732553 1.4037863326419908 1.1143145843793096 1.095957543841059 1.2013250468638905 1.581777438398999 1.1127701041832476 1.1091455923102127 1.0750388596352003 1.1241677300709838 1.0 10.323212028878384 -6.968967390321745 24.999678670708875 1.087286045869602 1.2648813763082818 0.33935681528075223 0.13585642195965422 274.90958083747427 221464.70294106175 0.05022459398017406 0.04429352267724171 1.0740700575383076e-07 6.968967390321745 0.1775953304386797 HSCSPMGDGDPEAMEES(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 HSCSPMGDGDPEAMEESPR 19 0 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 HSCSPMGDGDPEAMEES(1)PR;HSCSPMGDGDPEAMEES(1)PR;HSCS(0.239)PMGDGDPEAMEES(0.761)PR;HSCSPMGDGDPEAMEES(1)PR;HSCSPMGDGDPEAMEES(1)PR;HSCSPMGDGDPEAMEES(1)PR 148.36 2.4299e-05 76909700.0 152675.0 147382.0 204080.0 205242.0 226535.0 180322.0 152892.0 172525.0 175981.0 196305.0 True False 144189.93470644963 158685.72549217776 190949.71498550323 177287.68553780165 198075.64805140463 205159.7186998623 160001.7809497505 173027.01918694854 211182.1173199732 190637.1645883572 0.7563579484503923 0.8323965887492495 1.0016395040170731 0.9299744145933921 1.0390190626214428 1.0761790291146203 0.8393000456927815 0.9076248042220191 1.1077699239598884 1.0 17.540469873541248 -5.104341463854313 2.9527134614677126 0.9825408775057056 0.7618485760706138 0.5165110398321522 0.07606614220680141 0.22911668040617753 3.6652608982149157 0.020695460259494085 0.08142072351065131 7.86427218480475e-06 5.104341463854313 -0.22069230143509178 HSDLFSSSS(ph)PWDK ddPTM_A459_Selumetinib_30min_R2 1 HSDLFSSSSPWDK 13 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 HSDLFS(0.012)S(0.03)S(0.03)S(0.927)PWDK 164.53 1.3173e-06 0.0 8893.1 10111.0 10606.0 12074.0 15330.0 8805.1 10676.0 9823.0 7949.6 11143.0 True False 8398.857103899954 10886.4811880108 9923.621506939677 10429.500371188247 13404.108348061145 10017.922600260414 11172.455154092675 9851.583303714815 9539.74213038259 10821.272637009051 0.7761431936550264 1.0060259595325909 0.9170475451288989 0.9637961006101138 1.2386813268356924 0.9257619631538384 1.032452977469819 0.9103904535241195 0.8815730321548696 1.0 13.401582557007568 -4.758438643804811 24.719006604807525 0.987978710972349 0.7761428593745551 0.30104035888300495 0.09598387549078816 95.4661467119629 786253.7712375154 0.024457515386957663 0.16698942116966103 1.7440597370895093e-05 4.758438643804811 -0.21183585159779394 HSDPTLPGTDSLPCS(ph)PPVSNSYTQADPMAPR ddPTM_A459_Selumetinib_30min_R1 2 HSDPTLPGTDSLPCSPPVSNSYTQADPMAPR 31 0 A0A0A0MTL6;Q6ZS17-2;Q6ZS17;Q6ZS17-3;Q6ZS17-4 A0A0A0MTL6 FAM65A Protein FAM65A 1 HSDPTLPGTDS(0.003)LPCS(0.996)PPVS(0.001)NSYTQADPMAPR;HS(0.002)DPT(0.008)LPGT(0.021)DS(0.019)LPCS(0.924)PPVS(0.01)NS(0.007)Y(0.006)T(0.003)QADPMAPR 111.09 1.3295e-11 10833200.0 942.47 1340.98 1229.15 1030.47 1312.88 1144.15 1187.24 1213.75 433.69000000000005 1275.87 True False 964.4277172726157 1183.977438195311 1062.2381812376595 850.5177588175886 1194.13023580779 1132.6408898050806 1097.6855309475927 1181.5574071843619 735.940254535651 1439.640342526222 0.6699087881771064 0.8224119616693402 0.7378496905509659 0.5907848882069635 0.8294642769682178 0.7867526745031115 0.7624720553617017 0.8207309647290193 0.5111972989338803 1.0 10.491492720730768 HSDPTLPGTDSLPCS(ph)PPVSNSYTQADPMAPR ddPTM_A459_Selumetinib_30min_R2 1 HSDPTLPGTDSLPCSPPVSNSYTQADPMAPR 31 0 A0A0A0MTL6;Q6ZS17-2;Q6ZS17;Q6ZS17-3;Q6ZS17-4 A0A0A0MTL6 FAM65A Protein FAM65A 1 HSDPTLPGT(0.002)DS(0.007)LPCS(0.957)PPVS(0.014)NS(0.008)Y(0.008)T(0.003)QADPMAPR 63.427 0.00042704 3608600.0 8676.0 9754.1 9738.6 11568.0 14702.0 8369.6 9070.8 10067.0 7091.6 11333.0 True False 8193.822652779794 10502.20810562518 9112.02907858597 9992.418444086932 12855.00332245239 9522.4364283358 9492.61017344921 10096.29330331843 8510.118155859558 11005.786843329768 0.7445013036706041 0.9542441858203179 0.8279307248357677 0.9079240390834024 1.1680221964541653 0.8652208664305565 0.8625108144087269 0.9173622428856552 0.7732403213875845 1.0 13.425974671929303 -4.754018294410269 24.753833982952692 0.9180730351185232 0.744500954238162 0.20708397322627936 0.10275268547413158 401.5561003144247 1339305.9345045523 0.025997948532794093 0.2626265117773639 1.7619018257270392e-05 4.754018294410269 -0.17357208088036125 HSDSGTSEASLS(ph)PPSS(ph)PPSRPR ddPTM_A459_Selumetinib_30min_R2 1 HSDSGTSEASLSPPSSPPSRPR 22 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 2 HSDSGTSEAS(0.038)LS(0.961)PPS(0.029)S(0.967)PPS(0.004)RPR 94.295 0.00046628 6540300.0 11380.0 8503.0 11093.0 14437.0 16513.0 8937.2 7128.8 9186.4 8276.0 13021.0 True False 10747.54515774943 9155.152758545728 10379.288457145192 12470.655694785888 14438.489311906962 10168.21817617601 7460.303325449214 9213.13090310961 9931.431250760568 12645.049897379058 0.8499409053322182 0.7240108052435063 0.8208183076680867 0.9862085002425086 1.1418293663593713 0.8041263782030293 0.5899781642613773 0.7285958519641126 0.7854007165933807 1.0 13.626285109437852 -6.99107648654075 24.935335738212245 0.7453302962719055 0.9022708452784124 0.14986381571384955 0.1401641960142558 320.21893919143594 894796.2174630435 0.0523054953348594 0.04606503058285748 1.0207596949772976e-07 6.99107648654075 0.1569405490065069 HSEEAEFTPPLKCS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 HSEEAEFTPPLKCSPK 16 1 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 HSEEAEFT(0.002)PPLKCS(0.998)PK;HSEEAEFT(0.008)PPLKCS(0.992)PK;HSEEAEFTPPLKCS(1)PK 103.13 0.0025112 53124300.0 9692.7 10797.0 13311.0 12777.5 9142.599999999999 9781.2 8767.6 8886.3 7130.8 9335.1 True False 9918.521051288935 9532.882220610876 11503.439312089242 10546.149488380772 8315.653444257132 9682.810008619026 8106.252873164739 8650.606457229575 12100.44678697415 10533.351016574201 0.9416301645774614 0.9050189446464767 1.092096835469416 1.001215042751963 0.7894594446888243 0.9192525715114923 0.7695796770096782 0.8212587279791462 1.1487746651501622 1.0 13.362676859208756 -2.8048880045904925 9.402438162976825 0.9295205407058587 1.1370943434581278 0.0 0.11932396720454393 0.0 0.0 0.027890894114909533 0.0 0.0015671551543455112 2.8048880045904925 0.2075738027522691 HSEEAEFTPPLKCS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 HSEEAEFTPPLKCSPK 16 1 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 HSEEAEFT(0.283)PPLKCS(0.717)PK;HSEEAEFT(0.009)PPLKCS(0.991)PK 77.77600000000002 0.011666 29527000.0 257446.0 230375.0 256808.0 250498.0 234206.0 188477.0 220316.0 209778.0 171060.0 224149.0 True False 243138.18195799337 248044.0217276227 240285.25287140906 216379.74026684777 204782.94845179465 214437.9959261428 230561.13054787175 210388.41924938242 205276.77981574487 217677.23596095672 1.1169665072447144 1.1395037273080435 1.1038602718867092 0.9940393597503155 0.9407641894558288 0.985119068512084 1.0591880658996695 0.9665154848213818 0.9430328298204043 1.0 17.731831017087345 -5.73402145017628 3.9206251123469493 0.9830747440941384 1.1265227164282268 0.7965402063661196 0.03169206628325608 0.09650450367650654 3.1954566593961644 0.009541684911861845 0.016437049981651065 1.844924294538703e-06 5.73402145017628 0.14344797233408835 HSEEMICR ddPTM_A459_Selumetinib_30min_R1 1 HSEEMICR 8 0 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 0 101.6 0.020673 0.0 1176.2 1616.7 1132.3 1459.6 1351.7 1192.9 1318.9 1280.4 648.27 813.3 False True 1203.6031715132058 1427.4160124165612 978.53987927869 1204.708260085351 1229.4389736620183 1180.9005090665394 1219.4143111475178 1246.4396326746505 1100.0668422325307 917.6949772128638 1.3115503532215849 1.5554362264810186 1.0663018797930208 1.312754553527335 1.3397032828881268 1.286811564179046 1.3287795415978054 1.358228674695615 1.1987281935153982 1.0 9.841870901162375 -8.584557689555892 3.3383274947953576 1.0002689411348538 1.3183466255227063 0.44107515712882417 0.1110252791865102 0.271224343920833 7.968094874324559 0.10497225775834948 0.027759065571813124 2.6028090639776535e-09 8.584557689555892 0.31807768438785256 HSES(ph)PGATELNMCHSNCQNKPTLR ddPTM_A459_Selumetinib_30min_R2 2 HSESPGATELNMCHSNCQNKPTLR 24 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 HS(0.246)ES(0.753)PGAT(0.001)ELNMCHSNCQNKPTLR;HS(0.236)ES(0.762)PGAT(0.002)ELNMCHSNCQNKPTLR 72.09 0.00043663 6606700.0 27661.0 28143.1 29280.6 31819.6 32771.1 24562.7 22721.3 24887.5 23397.4 28035.1 True False 26123.712355756343 30301.585275670746 27396.7180743068 27485.715588128336 28654.101440648832 27945.98896700963 23777.8854714018 24959.91850465258 28077.533777977937 27225.65381906239 0.9595256198205786 1.11297915844558 1.0062832009979 1.0095520853528175 1.0524669721829158 1.0264579558946307 0.8733632488470638 0.916779397495188 1.0312896051854994 1.0 14.732679074963357 -7.1036736813744294 11.51428194983675 0.9484564997272962 1.0315043752738555 0.2953036228685715 0.054348139459255186 0.6999493071549068 74.42343345147849 0.02026543804699273 0.015698192654507635 7.876373795549004e-08 7.1036736813744294 0.08304787554655935 HSETFTR ddPTM_A459_Selumetinib_30min_R2 1 HSETFTR 7 0 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 89.75200000000002 0.042924 944370.0 1105.0 2427.9 842.43 1099.3 2718.4 1154.2 3188.8 6994.6 3539.1 6194.4 False True 1043.5885236654767 2614.1121230710532 788.2289709684327 949.5734436017266 2376.890289195658 1313.1805732155874 3337.085518487327 7014.953127981633 4247.018890716139 6015.551577015963 0.17348176809800586 0.43455900753290416 0.13103186979230202 0.15785309650237694 0.395124247338716 0.21829761683582732 0.5547430648317542 1.1661363115535661 0.7060065625474845 1.0 12.554481311496897 -7.537910878225663 3.9962656763316655 0.94959712780544 0.26150047015876654 0.8329382287319345 0.14118909662432672 0.07945900587211761 2.8989859662674164 0.0657139710107728 0.038079534201247746 2.897938213947632e-08 7.537910878225663 -0.6880966576466735 down HSGPNS(ph)ADSANDGFVR ddPTM_A459_Selumetinib_30min_R1 2 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 HSGPNS(0.999)ADS(0.001)ANDGFVR;HSGPNS(0.983)ADS(0.017)ANDGFVR 268.6 2.2375e-50 17085100.0 2165.3 1890.8 2294.3 2344.2400000000002 2241.6499999999996 2142.29 2013.8600000000001 1920.44 1345.29 1400.24 True False 2215.7472770596364 1669.4242569909268 1982.7466616878044 1934.862490834806 2038.8931532954523 2120.7405076436908 1861.9529188320128 1869.5036927317283 2282.858873905938 1579.9744434926108 1.402394378077166 1.0566147217549815 1.254923248824738 1.2246163213613113 1.290459577807081 1.3422625387254303 1.17847027621287 1.1832493243366007 1.4448707593393515 1.0 10.625685507276703 -10.474639806278557 4.189472836143047 0.9999899563688308 1.2548288070030484 0.34463874697743546 0.10861014026793214 72973549.67892773 160278193.87154728 11272.302251268879 0.02595292860323347 3.352433669236962e-11 10.474639806278557 0.25483885063421763 HSGPNS(ph)ADSANDGFVR ddPTM_A459_Selumetinib_30min_R2 2 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 HSGPNS(0.991)ADS(0.009)ANDGFVR;HSGPNS(0.917)ADS(0.083)ANDGFVR 169.72 1.0874e-05 9817700.0 24381.6 26777.7 27558.5 29524.8 32689.3 25818.9 26101.8 32498.2 22185.3 30505.0 True False 23026.568279278014 28831.46348612371 25785.41611342609 25503.471306879153 28582.57788795012 29375.219114361393 27315.5854197355 32592.76438163335 26622.97990907425 29624.241388491544 0.7772880316936452 0.9732388792012809 0.870416081724315 0.8608987137401185 0.964837462438917 0.9915939695850948 0.9220686890009979 1.1002058737711684 0.8986890013466057 1.0 14.854490589794127 -6.353061057305553 4.459789281733536 0.9842064358605186 0.8778876563320385 0.38966170239122455 0.06678845869513564 0.2445161415055993 8.473539698653523 0.020067619878460972 0.02299666165081848 4.435462815350349e-07 6.353061057305553 -0.10631877952848012 HSGPNSADSANDGFVR ddPTM_A459_Selumetinib_30min_R1 2 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 ; 127.2 0.001486 10921800.0 3497.2 4230.6 4430.2 4711.200000000001 4543.3 4029.9 4087.8 3024.8999999999996 1920.88 2577.2 False True 3578.6779556333804 3735.279385247419 3828.603173346688 3888.477360176835 4132.3593171847615 3989.362864856443 3779.453954893337 2944.6698257400426 3259.593064475644 2908.0087240538423 1.2306283423540103 1.2844801167034807 1.316572107118548 1.3371615181250878 1.421027138950306 1.3718538159318738 1.299670775961317 1.0126069435015634 1.120902092732268 1.0 11.505815882024937 -7.721444134416364 6.298789809697367 1.0498126387768034 1.3288523671177828 0.8371339219117359 0.05629373921204297 0.07212139441190087 7.454600426057829 0.029486627948558115 0.016401242811014093 1.899135122129897e-08 7.721444134416364 0.27903972834097934 HSHSHS(ph)PMSTR ddPTM_A459_Selumetinib_30min_R2 1 HSHSHSPMSTR 11 0 P62995 P62995 TRA2B Transformer-2 protein homolog beta 1 HS(0.16)HS(0.295)HS(0.524)PMS(0.01)T(0.01)R 70.438 0.034541 1652500.0 1250.4 703.24 2366.4 960.08 2633.7 2692.3 2389.0 6543.0 2838.3 5654.3 True False 1180.907773747794 757.1762467270019 2214.1484003415117 829.3154477696218 2302.8310604232647 3063.1398867339494 2500.0932337136946 6562.039046748037 3406.0393087281 5491.045667364289 0.21506063603995332 0.13789290648723518 0.4032289174903742 0.1510305136776789 0.4193793313557757 0.5578427265574466 0.45530366803773886 1.1950436117749184 0.620289743531309 1.0 12.422865194452008 -7.2268102641827925 0.8731356947878838 0.9550982487953633 0.21772142963502453 0.6992754668796002 0.18191545731986986 0.3170801979097941 0.4747802516782459 0.132478850536198 0.0798797119189026 5.931844200871963e-08 7.2268102641827925 -0.7373768191603388 HSHSHSPMST(ph)R ddPTM_A459_Selumetinib_30min_R2 1 HSHSHSPMSTR 11 0 P62995 P62995 TRA2B Transformer-2 protein homolog beta 1 HS(0.102)HS(0.102)HS(0.18)PMS(0.214)T(0.402)R 76.868 0.039553 1665100.0 1114.5 726.17 1071.7 800.75 2026.0 2124.4 2009.0 5724.8 2467.4 6014.2 True False 1052.5605516969906 781.8649039954314 1002.7479887787346 691.6864686292024 1771.4757673301942 2417.0168166168705 2102.422480757977 5741.458220208343 2960.948944916221 5840.554419231789 0.18021586242414198 0.1338682679543067 0.17168712365334426 0.1184282208469141 0.3033060973624482 0.41383345537507754 0.35996967579569433 0.9830330835207798 0.5069636771410608 1.0 12.511889609231678 -7.535278917374958 0.6439772780019271 0.9416022946626125 0.12219551766963506 0.7717109388452426 0.14881781073424794 0.3202199392369556 0.26320893230867737 0.12821655243869118 0.07583109647201008 2.9155539534955564e-08 7.535278917374958 -0.8194067769929774 down HSLDS(ph)DEEEDDDDGGSSK ddPTM_A459_Selumetinib_30min_R1 1 HSLDSDEEEDDDDGGSSK 18 0 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 HSLDS(1)DEEEDDDDGGSSK 274.23 2.0251e-54 5736600.0 1117.7 1122.4 833.13 773.46 814.38 784.96 976.1 1223.1 586.88 1175.3 True False 1143.7402353343905 990.9888862103966 719.9955220555112 638.3897306423787 740.7194727904664 777.0640150866554 902.4719911373813 1190.659414811281 995.8924959807307 1326.1612033914646 0.8624443487031901 0.7472612557780204 0.542917045238714 0.4813816970439112 0.5585440675659822 0.5859498928934335 0.6805145474241294 0.8978240441405936 0.7509588528407258 1.0 10.37304043959814 -7.660224218856269 4.12908690992093 0.868809720602433 0.6219044509096474 0.48126119141330936 0.11725838237435057 0.21394477556456665 6.619183506712238 0.06484938491742544 0.03506251197934054 2.186632411345495e-08 7.660224218856269 -0.2469052696927856 HSLDS(ph)DEEEDDDDGGSSK ddPTM_A459_Selumetinib_30min_R2 2 HSLDSDEEEDDDDGGSSK 18 0 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 HSLDS(1)DEEEDDDDGGSSK;HS(0.002)LDS(0.998)DEEEDDDDGGSSK 258.13 1.7549000000000003e-42 44595200.0 89107.0 66864.0 80905.0 75538.0 85538.0 69286.0 103648.0 107175.0 71427.0 65562.0 True False 84154.78966358336 71992.2537983538 75699.6603827036 65249.59408968174 74791.9517205777 78829.51758431405 108467.83737461564 107486.8615062235 85714.39583712835 63669.054709466654 1.3217534019877757 1.1307259724031935 1.1889553053384374 1.0248242947445565 1.1746986359679255 1.2381135222444768 1.7036194092966181 1.6882119892733665 1.3462489152423975 1.0 15.958304724325801 -7.0764428941336 6.75371956228952 1.4913823697034396 1.1635819834391847 0.2718489276203243 0.19813195941345615 0.2648267086151107 19.697638351521935 0.07340357852251511 0.05698345096588118 8.386043403936101e-08 7.0764428941336 -0.3278003862642549 HSLEEDEGSDFITENR ddPTM_A459_Selumetinib_30min_R2 1 HSLEEDEGSDFITENR 16 0 Q9NUQ3 Q9NUQ3 TXLNG Gamma-taxilin 0 174.39 1.6552e-08 0.0 7522.6 8359.9 8427.4 8873.5 9467.9 6864.6 6005.0 6490.6 7725.4 9434.7 False True 7104.524007353768 9001.077448684753 7885.190259059347 7664.913992358697 8278.457757900076 7810.136339365551 6284.244398681762 6509.486571423327 9270.695865711179 9162.295696705494 0.7754087231553066 0.9824041644848124 0.8606129424413405 0.8365713404245168 0.903535318214711 0.8524213360821631 0.6858809851488858 0.7104645808106758 1.01183111444926 1.0 13.161493408671323 -7.006175326262445 24.75311030067761 0.8195212185636536 0.8755571367033897 0.0 0.11103186065655231 854.1421301879592 3423743.6668948284 0.03930753408485929 0.03350060627093174 9.858814013739019e-08 7.006175326262445 0.056035918139736185 HSLGLTVS(ph)PCR ddPTM_A459_Selumetinib_30min_R2 1 HSLGLTVSPCR 11 0 G5E9D9;A0A0C4DFZ6;Q9H972-2;Q9H972 G5E9D9 C14orf93 Uncharacterized protein C14orf93 1 HSLGLTVS(1)PCR 135.91 0.00096492 3692300.0 10469.0 11025.0 11896.0 12262.0 12185.0 10250.0 10396.0 12432.0 10725.0 11024.0 True False 9887.174890727492 11870.58204903759 11130.624311385485 10591.894446870154 10654.211364717883 11661.84445976414 10879.434599283191 12468.175061771613 12870.299681537841 10705.708476208183 0.9235423244244173 1.1088086393738594 1.0396905852724847 0.9893688465746135 0.9951897521210535 1.0893108555758662 1.0162274288956297 1.164628673523125 1.2021903744287576 1.0 13.386092652273424 -7.756348906014318 24.988256426604917 1.1375571520322334 1.0272609119249942 0.29286723634407097 0.06915972412781138 132.88645363793714 652327.2122633233 0.03223634043591326 0.01787496299889254 1.7524720250246256e-08 7.756348906014318 -0.11029624010723915 HSLLLSSS(ph)PNR ddPTM_A459_Selumetinib_30min_R2 2 HSLLLSSSPNR 11 0 G1UD79;Q7Z309-4;Q7Z309-3 G1UD79 SPACIA2;FAM122B Protein FAM122B 1 HSLLLS(0.067)S(0.218)S(0.715)PNR;HSLLLS(0.045)S(0.186)S(0.769)PNR 124.42 0.0023674 5732600.0 40005.0 30123.0 39234.0 43221.0 48829.0 37545.0 36493.0 43854.0 39717.0 35347.0 True False 37781.68225270354 32433.33723928885 36709.72715474932 37334.22523961632 42694.66448320142 42716.482950423844 38189.99680950767 43981.60787957949 47661.50978570057 34326.44026746469 1.1006583251370168 0.9448500044448196 1.0694300623284716 1.087622979508378 1.2437836300686356 1.2444192470173323 1.1125533702865467 1.281274945403126 1.3884780773750993 1.0 15.067032633734986 -6.070474000629479 2.5480985312306834 1.2229085019136299 1.0286063385674513 0.3666382727982941 0.10393214633372304 0.28615214383791837 3.6645207322377535 0.031988270711529605 0.04606791347942318 8.502095901097432e-07 6.070474000629479 -0.19430216334617856 HSLS(ph)LDDIR ddPTM_A459_Selumetinib_30min_R1 2 HSLSLDDIR 9 0 Q96NE9-2;Q96NE9;Q96NE9-3 Q96NE9-2 FRMD6 FERM domain-containing protein 6 1 HSLS(1)LDDIR;HS(0.078)LS(0.922)LDDIR 123.51 0.005603100000000001 9529900.0 5098.299999999999 6024.3 6103.0 6582.6 6501.4 5347.4 5584.8 5600.200000000001 2869.6 4709.9 True False 5217.080470435109 5318.972155378911 5274.246121379357 5433.072480705555 5913.349517915397 5293.610011050729 5163.534039651721 5451.664503986703 4869.501612708398 5314.461543311035 0.9816762108292058 1.0008487430064394 0.9924328322626975 1.0223185239798767 1.1126902452343725 0.9960764543895231 0.9716006029154024 1.0258169072365113 0.9162737509762059 1.0 12.375707811197886 -6.990066243932541 24.999687325965255 0.9810405365705528 1.0227133154158172 0.19170865316372587 0.04221758920948756 384.0534477392907 966520.2112134341 0.015383310031522808 0.013550522485170611 1.0231369189591062e-07 6.990066243932541 0.041672778845264435 HSLS(ph)LDDIR ddPTM_A459_Selumetinib_30min_R2 2 HSLSLDDIR 9 0 Q96NE9-2;Q96NE9;Q96NE9-3 Q96NE9-2 FRMD6 FERM domain-containing protein 6 1 HS(0.025)LS(0.975)LDDIR;HSLS(1)LDDIR 158.47 0.00087461 15337500.0 86506.0 61635.1 74762.0 67846.1 65177.0 41123.7 53214.2 48133.9 41759.5 46322.4 True False 81698.34283095536 66362.31398191706 69951.89431471084 58605.344138949404 56988.88257022711 46788.11639121975 55688.76574193685 48273.961680003915 50112.566857918835 44984.9519519508 1.8161260440651077 1.4752114007546298 1.5550065361729775 1.3027766307619217 1.2668432464059962 1.0400837249130541 1.2379420967575774 1.0731135543184787 1.11398511465445 1.0 15.45715486154763 -1.5228787460406012 0.27906809974170915 1.0106584553036806 6.98990982434068 0.8944447509406044 0.08019606894731489 14.804413940928317 0.20851294185528418 0.08634400285226389 43.112747204583215 0.029999999947482845 1.5228787460406012 5.979251369037 HSLS(ph)PVPWEEDSFLQVK ddPTM_A459_Selumetinib_30min_R1 1 HSLSPVPWEEDSFLQVK 17 0 P10073 P10073 ZSCAN22 Zinc finger and SCAN domain-containing protein 22 1 HS(0.324)LS(0.676)PVPWEEDSFLQVK 84.859 0.0079664 6172200.0 4597.3 5415.3 6252.4 5572.9 5516.9 5189.8 5049.1 5078.1 3323.2 4260.2 True False 4704.40814521141 4781.274158495332 5403.3584219748145 4599.697631289155 5017.897369087804 5137.595323961377 4668.242321946269 4943.412292006514 5639.227683075182 4807.038167862093 0.9786500503913561 0.994640356812848 1.1240514914359274 0.9568672997108421 1.043864682131178 1.0687652447424394 0.9711265354946094 1.0283696778311773 1.1731189739196934 1.0 12.230932543175706 -8.03856816282623 24.913694913632003 1.0912878128603614 1.0214850650088898 0.15558985962952565 0.06128038194055712 888.1464486231396 573706.4133774263 0.03907177903098097 0.01477596401812397 9.150226345606284e-09 8.03856816282623 -0.06980274785147156 HSLSGS(ph)SPGMK ddPTM_A459_Selumetinib_30min_R1 4 HSLSGSSPGMK 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HSLS(0.003)GS(0.867)S(0.13)PGMK;HSLS(0.002)GS(0.89)S(0.108)PGMK;HSLS(0.011)GS(0.494)S(0.494)PGMK;HSLSGS(0.5)S(0.5)PGMK 187.85 1.9384e-05 75951000.0 34983.4 40085.0 37065.5 40940.3 42578.0 32799.3 39196.1 34802.8 13405.9 27064.899999999998 True False 35798.44515415326 35391.829564989086 32032.20868621768 33790.845149611065 38726.82741775643 32469.368821381657 36239.50662003883 33879.71668857333 22748.833171803548 30538.943549450913 1.1722227750343026 1.15890811703031 1.0488970790475696 1.106483762114902 1.2681128721773591 1.0632119205042196 1.186665365858421 1.10939386733247 0.7449122506470126 1.0 14.898362534600702 -8.153254030502323 6.4701220449747865 0.8751318764687704 1.1409168966728847 0.6268937961658636 0.08255127286204679 0.13595097610373957 6.856397404988586 0.05387754696970654 0.01994390131303168 7.02661194258908e-09 8.153254030502323 0.2657850202041142 HSLSGS(ph)SPGMK ddPTM_A459_Selumetinib_30min_R2 4 HSLSGSSPGMK 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HSLSGS(0.5)S(0.5)PGMK;HSLS(0.031)GS(0.484)S(0.484)PGMK;HSLS(0.001)GS(0.5)S(0.5)PGMK;HSLSGS(0.5)S(0.5)PGMK 182.92 3.3761e-05 80528500.0 176776.0 168845.0 218291.0 239682.0 245854.0 169417.0 186336.0 184280.0 157416.0 193047.0 True False 166951.49761039685 181794.8685777555 204246.39471726987 207036.89812548828 214967.6225573533 192752.6539355963 195000.99321777953 184816.22429080372 188903.59857053234 187473.2315136571 0.8905351247345129 0.969711073468705 1.0894696435762397 1.1043544534538308 1.1466576898563423 1.0281609399876088 1.0401537949889876 0.9858272714381635 1.0076297135613785 1.0 17.516325088608156 -4.996071813033903 3.3782508904839297 1.0536664288355981 0.8951608420142542 0.5264640241612917 0.048207578386910595 0.20540777628212964 4.738494557871658 0.013971832446917711 0.06439968618413679 1.0090860142355888e-05 4.996071813033903 -0.15850558682134397 HSLSGSS(ph)PGMK ddPTM_A459_Selumetinib_30min_R1 1 HSLSGSSPGMK 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HSLS(0.002)GS(0.205)S(0.793)PGMK 208.17 1.8094e-05 38366000.0 11364.0 12343.0 11689.0 12298.0 13727.0 10654.0 12324.0 10480.0 4280.0 9260.6 True False 11628.759089505238 10897.875821894982 10101.698003080995 10150.385162051003 12485.395273698692 10546.830433058021 11394.390757890675 10202.03635616239 7262.847401168087 10449.288215882747 1.112875714522805 1.0429299677398494 0.9667355129248497 0.9713948885650013 1.1948560529435006 1.0093348192872134 1.0904465952591285 0.9763379232525583 0.6950566632977621 1.0 13.351117051770432 -8.022816677026444 10.98703399387074 0.8434412216027197 1.0506627504295065 0.43650733350113935 0.09373835795644912 0.6348197018575956 300.37721822425175 0.057517741155616454 0.022993060284079943 9.488188911242778e-09 8.022816677026444 0.2072215288267868 HSLSGSS(ph)PGMK ddPTM_A459_Selumetinib_30min_R2 2 HSLSGSSPGMK 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 HSLSGS(0.013)S(0.986)PGMK;HSLS(0.01)GS(0.223)S(0.767)PGMK 190.66 1.985e-05 83785000.0 134561.0 135105.0 169391.0 178482.0 189805.0 116756.0 137467.0 134883.0 114492.0 143431.0 True False 127082.63831036224 145467.11906895463 158492.5674789763 154172.4437013765 165959.99902177087 132838.07919455823 143859.487885693 135275.48719891725 137393.59917376476 139289.77435150734 0.9123615778833876 1.0443488744684037 1.137862188497839 1.1068468192956629 1.1914729548126008 0.9536814874818605 1.0328072434280329 0.971180316923626 0.9863868314341765 1.0 17.08772982402086 -6.800055737650473 24.999997011869894 0.989759680068141 1.081541197122207 0.28868470750595565 0.07036949826603109 225.39332112582522 145916.754108958 0.026103551593857133 0.023021532597652886 1.5846897992382492e-07 6.800055737650473 0.09178151705406612 HSLSIPPVSS(ph)PPEQK ddPTM_A459_Selumetinib_30min_R1 1 HSLSIPPVSSPPEQK 15 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 HSLSIPPVS(0.098)S(0.902)PPEQK 108.17 0.0058722 0.0 1808.4 2174.2 2519.5 2247.1 2246.7 2071.5 1913.0 1820.8 1021.3 1515.2 True False 1850.5322014661458 1919.643653241843 2177.365738622857 1854.6861682911697 2043.4863816871025 2050.662590771514 1768.7008698348634 1772.5064692080625 1733.0715071992913 1709.6906792978373 1.082378364620992 1.122801730445318 1.2735436678622427 1.084808024485974 1.19523748151119 1.1994348542706639 1.0345151267720905 1.036741026122938 1.0136754725194246 1.0 10.739519618071892 -7.305455743755302 7.810986610744341 1.0237605025696674 1.1613683632310396 0.607480158469925 0.054507416655291935 0.21459402572420103 34.392015483101055 0.022947077656388152 0.015517861987905487 4.949305436385454e-08 7.305455743755302 0.1376078606613722 HSLSIPPVSS(ph)PPEQK ddPTM_A459_Selumetinib_30min_R2 4 HSLSIPPVSSPPEQK 15 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 HSLSIPPVS(0.249)S(0.751)PPEQK;HSLSIPPVS(0.233)S(0.767)PPEQK;HSLSIPPVS(0.139)S(0.861)PPEQK;HSLSIPPVS(0.044)S(0.956)PPEQK 125.18 0.00082827 18672500.0 349748.0 320892.0 355228.0 377199.0 379761.0 273861.0 294739.0 299924.0 250628.0 359674.0 True False 330310.4063121747 345503.3845695938 332373.0172230028 325823.8454954319 332052.0280735846 311582.86688736256 308444.94751424884 300796.72918490856 300760.6031314181 349289.27707471815 0.9456643189235849 0.9891611545111519 0.9515694842012092 0.9328194905500445 0.9506505062351335 0.8920481885297337 0.8830644619195335 0.86116794567548 0.8610645183564595 1.0 18.41406282816706 -6.753112228517588 4.634111659520297 0.8892238838117836 0.9552600529432494 0.3066200563551712 0.03956022959767162 0.20013245015581455 10.738637739303908 0.013253350607143138 0.012501495569458438 1.7655815077277664e-07 6.753112228517588 0.06603616913146582 HSLYTAELITVPFDS(ph)ESPIR ddPTM_A459_Selumetinib_30min_R1 1 HSLYTAELITVPFDSESPIR 20 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 HSLYTAELITVPFDS(0.856)ES(0.144)PIR 134.62 7.8804e-05 8525200.0 1690.1 3020.2 2296.7 2771.1 2346.0 2049.7 1831.8 1560.5 1048.3 1412.8 True False 1729.4760416378747 2666.5935799471113 1984.8207548700584 2287.179404989393 2133.8047142199416 2029.0818789786958 1693.6258512093589 1519.1104707816246 1778.8885351973124 1594.1466418373707 1.0848914373677236 1.672740455591756 1.2450678643856798 1.4347358925231943 1.33852473682131 1.2728326401892553 1.0624027970584506 0.9529301953242761 1.115887640767485 1.0 10.638568630251973 -7.16277965973735 2.2670187125123866 1.019580620746801 1.3712760572565177 0.5294070554387083 0.14425052846909933 0.22780859142542892 2.291714025626562 0.06201425803535683 0.04363620993523094 6.874171141445006e-08 7.16277965973735 0.3516954365097167 HSPEEDFRQS(ph)PQEHFR ddPTM_A459_Selumetinib_30min_R2 1 HSPEEDFRQSPQEHFR 16 1 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 1 HSPEEDFRQS(1)PQEHFR 61.649 0.029249 11749000.0 22820.0 19647.0 28721.0 22341.0 25526.0 25676.0 16319.0 18650.0 17178.0 21892.0 True False 21551.755755697908 21153.86172493802 26873.12212906039 19298.11725962538 22319.19567466464 29212.635936478426 17077.86583548503 18704.26841232629 20614.079993422565 21259.921077753035 1.01372698783206 0.9950113007274519 1.2640273701289118 0.9077229021240092 1.049824954337204 1.3740707611114948 0.8032892395520592 0.879790115114724 0.9696216612484844 1.0 14.37584862077662 -7.32960486352163 24.999970399049076 0.9031577957824243 1.0922676458397476 0.31155534304975496 0.13591032583290052 225.97148739211187 82874.81595954842 0.056737005623614195 0.038252086063108565 4.681608969144909e-08 7.32960486352163 0.18910985005732328 HSPIAPSS(ph)PSPQVLAQK ddPTM_A459_Selumetinib_30min_R1 1 HSPIAPSSPSPQVLAQK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 HSPIAPS(0.013)S(0.98)PS(0.007)PQVLAQK 176.42 9.3697e-08 12090000.0 653.14 836.14 801.66 894.26 850.97 768.98 762.84 896.03 335.78 593.34 True False 668.3568912107935 738.2443400890596 692.7989752031748 738.0942783392209 773.9999137509564 761.2447593779763 705.2983646339922 872.2643736843695 569.7941355991163 669.5009686210261 0.9982911489843113 1.1026785242889559 1.0347990632935689 1.102454384583605 1.1560848303851854 1.137033096376119 1.0534687740432969 1.3028575230906327 0.8510729069932843 1.0 9.386942332589046 -1.5663054177634006 19.76999944966057 1.0862648738546474 0.00541832951294241 0.0 0.11362953069232593 0.0 0.0 0.02399673353481411 0.0 0.02714529603431366 1.5663054177634006 -1.080846544341705 HSPIAPSS(ph)PSPQVLAQK ddPTM_A459_Selumetinib_30min_R2 2 HSPIAPSSPSPQVLAQK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 HS(0.001)PIAPS(0.063)S(0.916)PS(0.021)PQVLAQK;HS(0.035)PIAPS(0.042)S(0.921)PS(0.002)PQVLAQK 83.948 0.0084085 20057000.0 116314.0 100572.0 111411.0 148867.0 145820.0 124024.0 121425.0 133961.0 110286.0 128598.0 True False 109849.73352183384 108285.54901005093 104242.93755512529 128591.05779010119 127500.78795265987 141107.1802222233 127071.50309907303 134350.80433156248 132346.2816483059 124885.04160226954 0.8796068136941513 0.8670818187731064 0.8347111568983204 1.0296754210134667 1.0209452334469398 1.1298965705726198 1.0175077933173684 1.0757958087521742 1.0597448657606148 1.0 16.93024115956046 -5.815163847205793 5.463127304213339 1.0535284458903615 0.8609874746007997 0.850059007078651 0.03602883206614956 0.06418161074811174 4.0371652785923295 0.009985229351381197 0.01532418159707691 1.530509933998054e-06 5.815163847205793 -0.19254097128956182 HSPQQPSNGS(ph)LR ddPTM_A459_Selumetinib_30min_R1 3 HSPQQPSNGSLR 12 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 HSPQQPS(0.001)NGS(0.999)LR;HSPQQPSNGS(1)LR;HSPQQPSNGS(1)LR 161.04 0.00047841 45177000.0 1706.12 1537.68 1591.37 1816.37 1874.01 1494.01 1786.45 1524.51 626.71 1226.34 True False 1745.869276468382 1357.6477107519618 1375.270694769699 1499.1750769876871 1704.5061263833386 1478.9816158525452 1651.6966382208532 1484.0750424936193 1063.481096912629 1383.7526845631658 1.2616916996403387 0.9811346535385801 0.9938702993041387 1.0834125878938827 1.2317996889172655 1.0688193290258672 1.1936357245386477 1.0725002083462076 0.7685485338359849 1.0 10.4343704005865 -8.121501432184239 6.369185853380074 0.8873491864594298 1.1093945632536586 0.4438393886381169 0.10216259729700858 0.21650663870392628 10.223579906030542 0.06970449457236054 0.02584069066690921 7.559595673872309e-09 8.121501432184239 0.22204537679422875 HSPQQPSNGS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 HSPQQPSNGSLR 12 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 HSPQQPSNGS(1)LR 172.09 0.00023898 36969000.0 6224.2 4360.7 6390.1 7411.9 5895.3 3094.9 6809.4 5009.6 3626.9 5220.8 True False 5878.283881446755 4695.151668139522 5978.967923014824 6402.386433759331 5154.679709349307 3521.194382295027 7126.050592570123 5024.177106616073 4352.381344053109 5070.061938732551 1.159410664500925 0.9260541044422128 1.179269207213963 1.2627826861144509 1.0166896916919932 0.69450717266292 1.405515490477724 0.99094984781824 0.8584473713828331 1.0 12.307787656773634 -6.492232878675498 24.28994651224561 0.9975512198654948 1.1229591303424562 0.11760334999061228 0.18452418568646206 1257.6195342426377 996791.0317293435 0.05847668939645454 0.06621267912862759 3.219342043222657e-07 6.492232878675498 0.12540791047696143 HSPS(ph)PPPPTPTESR ddPTM_A459_Selumetinib_30min_R1 1 HSPSPPPPTPTESR 14 0 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 HS(0.065)PS(0.935)PPPPTPTESR 153.32 0.00036562 2103100.0 458.9 541.63 585.29 502.93 607.45 291.83 374.91 263.17 204.04 282.97 True False 469.5914771360396 478.2157078030446 505.8108327678395 415.10271666533686 552.506254754008 288.89445516043963 346.63023685822725 256.18987670336423 346.2409775080222 319.29195586121216 1.4707275536254307 1.4977380388841128 1.5841640338339817 1.3000725794851253 1.7304108187246907 0.9047971608968892 1.085621577666361 0.8023687161562042 1.084402444697116 1.0 8.318732396345977 -6.771962257294838 24.999992721429518 0.9699723981297019 1.507295212466485 0.8207635994288894 0.12639970522793886 80.26797155201177 190697.49582778322 0.0411599030742677 0.036677600885106285 1.6905878471321526e-07 6.771962257294838 0.537322814336783 HSPS(ph)PPPPTPTESR ddPTM_A459_Selumetinib_30min_R2 2 HSPSPPPPTPTESR 14 0 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 HS(0.003)PS(0.99)PPPPT(0.002)PT(0.004)ESR;HS(0.04)PS(0.96)PPPPTPTESR 101.3 0.012482 0.0 8114.599999999999 7772.2 8396.5 9596.1 9691.8 6681.0 7347.2 7486.6 4857.0 7706.9 True False 7663.623017317538 8368.302748438091 7856.2783314179715 8289.094625804177 8474.229438208677 7601.247105920408 7688.859358200607 7508.384766526653 5828.535715918818 7484.381772069019 1.0239487042092683 1.1181020695213302 1.0496896832196394 1.1075189478893592 1.13225510085999 1.015614560749362 1.0273205713389286 1.0032070777772468 0.7787598085482951 1.0 12.869667435787958 -7.882439923858208 2.220849675652391 0.8911814480255118 1.0751145325263634 0.5359260352685984 0.06441683105566141 0.22210567077653146 2.108146277937068 0.04579981486034979 0.017323557607659114 1.3108713632221193e-08 7.882439923858208 0.18393308450085155 HSPT(ph)EDEESAK ddPTM_A459_Selumetinib_30min_R1 1 HSPTEDEESAK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HS(0.163)PT(0.837)EDEESAK 165.35 0.001538 12961000.0 2878.0 2704.0 1597.6 1050.6 1634.8 1801.4 2574.0 2866.3 2104.7 2802.0 True False 2945.0518003868433 2387.414422944503 1380.6546949886388 867.1324322044877 1486.932628647383 1783.2795515403345 2379.84110766071 2790.2764129454463 3571.5221787940345 3161.6639937912723 0.9314879146456417 0.7551132655566168 0.4366860924183923 0.27426457520701814 0.4703006491415127 0.5640319638779628 0.7527179081439807 0.8825341397519978 1.1296336947277201 1.0 11.626468337921686 -7.716908584775696 1.7615419992824535 1.0558509292923943 0.5563623531977366 0.5638981374553929 0.17287197358476736 0.30105657831551214 1.806799178625414 0.14142248764469958 0.05869869865984719 1.9190726463184547e-08 7.716908584775696 -0.4994885760946577 HSPT(ph)EDEESAKAEADAYIR ddPTM_A459_Selumetinib_30min_R1 2 HSPTEDEESAKAEADAYIR 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HS(0.133)PT(0.867)EDEESAKAEADAYIR;HS(0.008)PT(0.992)EDEESAKAEADAYIR 130.64 0.00039247 24545000.0 2946.63 2803.42 3437.1 2456.5 2991.3 2848.7 3288.8 3099.46 1790.4 3124.51 True False 3015.2807458561106 2475.1942831254 2970.360698638864 2027.5183892159953 2720.7374431569106 2820.0446644126523 3040.7231681719286 3017.252252335028 3038.178034357789 3525.571293804701 0.8552601818476068 0.7020689916198625 0.8425189709986921 0.5750893175182262 0.771715338146166 0.7998830343803193 0.8624767207275683 0.8558193838363403 0.8617548139493357 1.0 11.783641339608192 -8.13498331646291 0.6152017616423714 0.9900344941262729 0.7433650260715088 0.4863120329701358 0.0768821625289771 0.6253048406845846 0.5415989927989918 0.07591819122328859 0.03653939303749604 7.328526853273997e-09 8.13498331646291 -0.24666946805476408 HSPTEDEES(ph)AKAEADAYIR ddPTM_A459_Selumetinib_30min_R1 1 HSPTEDEESAKAEADAYIR 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 HSPT(0.008)EDEES(0.992)AKAEADAYIR 62.999 0.016449000000000002 5590300.0 981.82 1547.3 1314.5 1631.2 1371.0 1404.5 1179.4 1089.6 934.21 1066.7 True False 1004.694495710845 1366.1413966797452 1135.9981200316513 1346.3415414162957 1246.99329206971 1390.3720051839668 1090.4369084596128 1060.7002684803954 1585.286138001223 1203.621335537885 0.834726392800156 1.1350259058586991 0.9438168687197509 1.1185756696599523 1.0360345527710695 1.1551573274186147 0.9059634257582421 0.8812574496333435 1.3170970729700269 1.0 10.23316587006004 -4.746087961341613 24.745396541678893 1.047487185105917 0.8347257360342543 0.21454039669499048 0.12561608189475756 1214.7821824175971 1958018.8229919407 0.02991770030556271 0.6958515439859777 1.794370161031735e-05 4.746087961341613 -0.21276144907166283 HSPTSEPTPPGDALPPVS(ph)SPHTHR ddPTM_A459_Selumetinib_30min_R1 4 HSPTSEPTPPGDALPPVSSPHTHR 24 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3;Q9H6S3-2;A0A087WX39 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 1 HSPTSEPTPPGDALPPVS(0.706)S(0.147)PHT(0.147)HR;HSPTSEPTPPGDALPPVS(0.694)S(0.229)PHT(0.077)HR;HSPTSEPTPPGDALPPVS(0.838)S(0.081)PHT(0.081)HR;HSPTSEPTPPGDALPPVS(0.917)S(0.06)PHT(0.023)HR 92.412 1.738e-05 53664700.0 5891.83 5878.099999999999 4616.04 5052.299999999999 11474.3 4817.58 8581.14 6477.900000000001 1473.35 2948.26 True False 6029.098175494517 5189.889319345447 3989.207122092737 4170.01064841684 10436.451590952198 4769.119519212659 7933.857701084547 6306.085048815303 2500.167340773596 3326.6978894843205 1.812337151068774 1.5600723275024966 1.1991492027883282 1.2534984500991893 3.1371804527071068 1.4335896067652634 2.384904780852942 1.895598956775971 0.7515462551248239 1.0 11.699875140022346 -8.259179586958773 24.868775590878414 0.8757730488609231 1.833246273078759 0.32807149309013395 0.5488439970649563 213.2952267459836 2347367.870778865 0.42378512545900476 0.14246306122554253 5.5057997665756106e-09 8.259179586958773 0.957473224217836 HSPTSEPTPPGDALPPVS(ph)SPHTHR ddPTM_A459_Selumetinib_30min_R2 4 HSPTSEPTPPGDALPPVSSPHTHR 24 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3;Q9H6S3-2;A0A087WX39 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 1 HSPTSEPTPPGDALPPVS(0.475)S(0.475)PHT(0.051)HR;HSPTSEPTPPGDALPPVS(0.427)S(0.427)PHT(0.146)HR;HSPTSEPTPPGDALPPVS(0.442)S(0.442)PHT(0.116)HR;HSPTSEPTPPGDALPPVS(0.473)S(0.473)PHT(0.054)HR 154.17 1.1418e-10 95776000.0 106007.0 107238.0 144023.0 154877.0 187005.0 106762.0 122271.0 157481.0 117169.0 151305.0 True False 100115.55531964367 115462.80977548231 134756.7169803857 133782.48542227293 163511.76005408843 121467.4964110575 127956.84377539025 157939.2436376169 140606.0739753945 146936.43151239865 0.6813528427849141 0.78580110178965 0.9171089538064275 0.9104786610459111 1.112806118748645 0.8266669821827539 0.8708313007083823 1.074881443709825 0.9569177128378134 1.0 17.164832617410006 -5.053013827946528 1.4099407595033349 0.9654726028338328 0.6351868770717857 0.5761719677598436 0.08097713355863648 0.5752561949275639 1.4795288044983197 0.024734413089255503 0.23446223406987157 8.850874281776353e-06 5.053013827946528 -0.3302857257620472 HSQAVEELAEQLEQTK ddPTM_A459_Selumetinib_30min_R2 1 HSQAVEELAEQLEQTK 16 0 P35579 P35579 MYH9 Myosin-9 0 103.67 0.011409 0.0 13944.0 14758.0 15830.0 15829.0 15985.0 14579.0 15018.0 12968.0 16041.0 17272.0 False True 13169.048302254672 15889.891145550722 14811.515034400827 13673.062893451943 13976.821392286854 16587.124915014763 15716.366757602445 13005.734733032023 19249.648222988195 16773.31248195461 0.78511911802886 0.9473317308459908 0.8830405473179873 0.8151677200411047 0.8332773509897743 0.9888997735456158 0.9369864643319995 0.775382605375301 1.1476354622080596 1.0 14.033880007591637 -8.266314399381015 24.995716017755644 1.073817738068105 0.8766773169009547 0.5379634259150355 0.07514802376688966 336.128673267609 1723402.582389698 0.06406653222740696 0.018580830437694894 5.41608660967991e-09 8.266314399381015 -0.19714042116715036 HSQFIGYPITLFVEK ddPTM_A459_Selumetinib_30min_R1 2 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 ; 125.52 0.0017170000000000002 17941600.0 7154.2 8360.1 9359.7 9676.400000000001 7827.0 7914.0 8443.7 8106.5 4953.799999999999 6586.4 False True 7320.878940350089 7381.295605494949 8088.704149151954 7986.598388524181 7119.049231969083 7834.392345337079 7806.784910938134 7891.489286376954 8406.236788763192 7431.828596968897 0.9850710151383121 0.9932004632756791 1.0883868005851167 1.0746478184092607 0.9579135389199662 1.0541675232569774 1.050452766647789 1.06185028131509 1.1311128451202053 1.0 12.85950151335325 -7.2446132719598015 2.423974139170621 1.068875937891465 1.0247724155627254 0.12622858436260853 0.0478238492165942 0.6360598701440924 7.351712933688335 0.023025692266370714 0.015422575999079337 5.693597053152732e-08 7.2446132719598015 -0.0441035223287396 HSQFLGYPITLYLEK ddPTM_A459_Selumetinib_30min_R1 2 HSQFLGYPITLYLEK 15 0 Q58FF8 Q58FF8 HSP90AB2P Putative heat shock protein HSP 90-beta 2 0 ; 126.63 0.0015826 11364100.0 5967.4 6564.299999999999 7003.0 7498.6 6431.1 5770.200000000001 5986.5 5881.6 3488.8999999999996 5123.4 False True 6106.428809460895 5795.7487043397205 6052.03106472549 6189.110276155118 5849.408140502924 5712.157026922412 5534.933485241198 5725.60086187068 5920.40848082601 5781.038296142117 1.0562858255991698 1.0025445962202706 1.0468761413956063 1.0705880084353223 1.0118265683184338 0.9880849657637327 0.9574289602846683 0.9904104710206759 1.0241081580063047 1.0 12.497112914095466 -6.512262455861401 4.911251255710139 0.9899315046296617 1.0415538743837878 0.546521899120527 0.022260125330208616 0.15285088031854213 10.380810640828857 0.007619674345489932 0.008138526535146207 3.074238408121518e-07 6.512262455861401 0.05162236975412604 HSQPAT(ph)PTPLQSR ddPTM_A459_Selumetinib_30min_R1 2 HSQPATPTPLQSR 13 0 Q9NR12-2;Q9NR12 Q9NR12-2 PDLIM7 PDZ and LIM domain protein 7 1 HSQPAT(1)PTPLQSR;HSQPAT(1)PTPLQSR 145.94 0.00083212 17483100.0 5878.5 7110.0 6915.799999999999 7442.0 7473.8 5832.0 6515.6 5554.7 4160.5 5410.9 True False 6015.457612430177 6277.557894650676 5976.672345770173 6142.394403641538 6797.79610960656 5773.335375032322 6024.123046260348 5407.371311791531 7060.064629102762 6105.441721629266 0.9852616545531325 1.0281906176274958 0.9789090811557644 1.006052417449398 1.1133995572383477 0.9456048617382725 0.9866809513420075 0.8856642251837838 1.1563560756122901 1.0 12.575879960964132 HSQPAT(ph)PTPLQSR ddPTM_A459_Selumetinib_30min_R2 2 HSQPATPTPLQSR 13 0 Q9NR12-2;Q9NR12 Q9NR12-2 PDLIM7 PDZ and LIM domain protein 7 1 HSQPAT(0.999)PT(0.001)PLQSR;HSQPAT(1)PTPLQSR 135.69 0.0015373 14340800.0 54306.0 55846.0 62425.0 59036.0 67045.0 46750.0 51959.0 48692.0 39854.9 52401.0 True False 51287.889924142444 60129.20862680754 58408.64346320099 50995.1949572196 58622.2077100952 53189.38814575353 54375.19645480525 48833.685658605435 47826.99363894851 50888.04697585135 1.00785730583217 1.181597883985242 1.1477870921420603 1.0021055628528857 1.1519838389143535 1.0452236096031406 1.0685259051228417 0.9596297865740299 0.9398473016982662 1.0 15.635039202966707 -7.63644749161127 2.1650685038089694 0.9586906304646803 1.0956298496634904 0.4610270400035612 0.05896776374780021 0.27063603263411173 2.5295198539765753 0.036288215010112354 0.017141425054410606 2.3096836944220726e-08 7.63644749161127 0.13693921919881014 HSQPS(ph)PEPHS(ph)PTEPPAWGSSIVK ddPTM_A459_Selumetinib_30min_R2 2 HSQPSPEPHSPTEPPAWGSSIVK 23 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 2 HS(0.058)QPS(0.966)PEPHS(0.746)PT(0.23)EPPAWGSSIVK;HS(0.363)QPS(0.911)PEPHS(0.697)PT(0.028)EPPAWGSSIVK 79.898 0.0024066999999999995 15802800.0 44015.9 42669.0 53102.0 49231.0 55137.0 36069.0 43185.0 44553.2 34550.3 49185.0 True False 41569.672487608404 45941.57509754058 49685.47513308608 42525.65287178806 48210.197128965934 41037.177348217825 45193.1880694541 44682.842435820654 41461.325416040716 47764.901252022806 0.8702974652511809 0.9618270716218636 1.0402088946218002 0.8903117510367956 1.0093226587990543 0.8591492135970852 0.9461589343815551 0.9354744020103751 0.8680291245087597 1.0 15.543663261570712 -6.7549407108349415 24.997273511846704 0.9192542733103236 0.9560139417813395 0.06889833190375005 0.05947433346382359 419.488447807418 1613567.8579997548 0.019179914759948256 0.018745848234106074 1.7581636191679315e-07 6.7549407108349415 0.03675966847101586 HSQPS(ph)PEPHSPTEPPAWGSSIVK ddPTM_A459_Selumetinib_30min_R2 4 HSQPSPEPHSPTEPPAWGSSIVK 23 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 HS(0.055)QPS(0.944)PEPHS(0.001)PTEPPAWGSSIVK;HS(0.056)QPS(0.943)PEPHS(0.001)PTEPPAWGSSIVK;HS(0.15)QPS(0.819)PEPHS(0.029)PT(0.001)EPPAWGSSIVK;HS(0.032)QPS(0.938)PEPHS(0.029)PT(0.001)EPPAWGSSIVK 116.83 1.9305e-05 27312600.0 119021.0 98152.2 123778.0 136953.0 141535.0 99554.6 103406.0 99132.4 80285.4 109696.0 True False 112406.28929881322 105680.15813093427 115814.25823929672 118299.7651428974 123754.107961046 113267.3424833205 108214.58389510166 99420.85887174777 96344.72336150458 106528.79145556358 1.0551728576185089 0.9920337655854915 1.0871639174429797 1.1104957028658666 1.161696347720866 1.0632556789172605 1.0158247588891618 0.9332768870584555 0.9044007919839485 1.0 16.700883873681633 -7.519377300146331 2.5885087769385375 0.9389807880045585 1.079972686478518 0.621681454023397 0.04621236307801089 0.19964518314050306 2.679599495625253 0.027390489163897972 0.015015611329728753 3.02428489151725e-08 7.519377300146331 0.14099189847395943 HSQPSPEPHS(ph)PTEPPAWGSSIVK ddPTM_A459_Selumetinib_30min_R1 2 HSQPSPEPHSPTEPPAWGSSIVK 23 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 HSQPS(0.002)PEPHS(0.944)PT(0.054)EPPAWGSSIVK;HS(0.002)QPS(0.004)PEPHS(0.94)PT(0.055)EPPAWGSSIVK 123.84 6.8986e-06 12553100.0 3108.94 3548.3 4126.6 4193.7 4766.299999999999 3903.1 4083.7 3642.7 1396.9 2604.81 True False 3181.3722530558293 3132.8633864400836 3566.230385791262 3461.3490204987224 4335.189006558612 3863.838357731251 3775.66322119427 3546.083762842822 2370.437274460678 2939.162736498019 1.0824076576468848 1.0659033429951745 1.213349074383131 1.1776649783682556 1.4749741321652516 1.3146051117723998 1.2846050252028347 1.20649452948221 0.8065008599302769 1.0 11.521189525461091 -8.211838162162952 7.516713341504587 0.9040183812317312 1.2336815649077928 0.5431104782855877 0.11888097274360539 0.1961613868206794 26.671066924450322 0.09003274986619268 0.03326388492020554 6.139907633674304e-09 8.211838162162952 0.3296631836760616 HSQPSPEPHSPT(ph)EPPAWGSSIVK ddPTM_A459_Selumetinib_30min_R2 1 HSQPSPEPHSPTEPPAWGSSIVK 23 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 HS(0.265)QPS(0.232)PEPHS(0.099)PT(0.403)EPPAWGSSIVK 55.662 0.014797 5759400.0 28727.0 22893.0 40124.0 35281.0 46887.0 34476.0 30592.0 29682.0 26361.0 42046.0 True False 27130.468343292436 24648.81948740296 37542.46552370807 30475.666936880287 40996.63588490172 39224.75605803206 32014.588616897974 29768.36970588039 31633.936587880547 40832.022731372395 0.6644409590428478 0.6036639342989143 0.9194368295368119 0.7463668194293244 1.004031471931045 0.9606371037772412 0.7840559069903794 0.7290446986112327 0.774733517268918 1.0 15.31741341691997 -5.256295711348286 24.980202624559706 0.8563948241579513 0.6340524251908018 0.4600068564207086 0.09966564741191485 395.08736703965207 1918724.3001265181 0.026763614741015008 0.06643891062607349 5.542481965492824e-06 5.256295711348286 -0.22234239896714947 HSS(ph)EDFR ddPTM_A459_Selumetinib_30min_R2 1 HSSEDFR 7 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 HS(0.045)S(0.955)EDFR 96.034 0.023406 8392400.0 87752.0 54539.0 63695.0 75348.0 93504.0 78657.0 106950.0 185810.0 97383.0 105060.0 True False 82875.09513908859 58721.965929474965 59596.933045872436 65085.472417450044 81757.19158363412 89491.28777284568 111923.38691740466 186350.67633749856 116862.32110836334 102026.6448213382 0.8122887436337201 0.5755551996471578 0.5841310684109464 0.6379262253641986 0.8013317670771346 0.8771364375409626 1.0970015441887453 1.8264902924507869 1.145409822238145 1.0 16.63858644361121 -7.213233117192023 2.007534982727175 1.3684099910422978 0.6701491279758583 0.6158017733986012 0.21882338400202356 0.197839446994787 1.5596275238162185 0.10491942820937586 0.06943626564702243 6.120217872761793e-08 7.213233117192023 -0.6982608630664394 HSS(ph)ETFSSTPSATR ddPTM_A459_Selumetinib_30min_R1 4 HSSETFSSTPSATR 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 HS(0.099)S(0.899)ET(0.002)FSSTPSATR;HS(0.113)S(0.881)ET(0.006)FSSTPSATR;HS(0.002)S(0.996)ET(0.002)FSSTPSATR;HS(0.128)S(0.869)ET(0.003)FSSTPSATR 174.95 7.647699999999999e-05 157094900.0 8803.9 9835.0 9328.4 9452.4 10707.2 8919.8 10161.800000000001 8649.7 3468.7400000000002 8015.299999999999 True False 9009.013740592682 8683.51362783254 8061.65451723336 7801.715783523415 9738.735650509692 8830.074910530408 9395.287244687885 8420.281857814685 5886.198433254153 9044.141830633542 0.9961159288853834 0.9601257687512692 0.8913675468829574 0.8626264304146705 1.0768004121213006 0.9763308753763608 1.0388257305812005 0.9310205451770148 0.6508299563941962 1.0 13.142767901336583 -8.019466611359537 24.876623130867674 0.813918370451932 0.9694169852343995 0.25635723897429274 0.09793665174725084 878.2652206427412 1122339.2835265659 0.061557390990125936 0.024040495747531917 9.5616620242945e-09 8.019466611359537 0.1554986147824674 HSS(ph)ETFSSTPSATR ddPTM_A459_Selumetinib_30min_R2 2 HSSETFSSTPSATR 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 HS(0.05)S(0.948)ETFSS(0.001)TPSATR;HS(0.01)S(0.99)ETFSSTPSATR 106.55 0.0054871 26902000.0 44017.0 34102.0 46778.0 54600.0 53767.0 40150.0 41401.0 42909.0 42347.0 52351.0 True False 41570.71135401201 36717.51374478731 43768.35440803548 47163.385809746454 47012.30877692132 45680.29805458831 43326.228534525166 43033.85808603265 50817.58327404035 50839.49060576692 0.8176854421373074 0.7222242651782649 0.8609125285584719 0.9276919427748265 0.9247202955174483 0.8985199794548416 0.8522160237697288 0.8464651705450241 0.9995690882920828 1.0 15.63366195465598 -1.5228787452803376 0.17935308391551888 0.981501029392402 0.0900682701835351 0.516992497393745 0.05564297155196818 52.78334360138967 0.5932816170425543 0.13825549758628367 12.808384152941718 0.029999999999999995 1.5228787452803376 -0.8914327592088669 HSS(ph)ETFSSTTTVTPVS(ph)PSFAHNPK ddPTM_A459_Selumetinib_30min_R2 1 HSSETFSSTTTVTPVSPSFAHNPK 24 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 2 HS(0.192)S(0.531)ET(0.235)FS(0.009)S(0.011)T(0.006)T(0.007)T(0.008)VT(0.001)PVS(0.823)PS(0.177)FAHNPK 86.869 0.00036543 4820800.0 18227.0 16105.0 25097.0 28937.0 31594.0 19115.0 17987.0 26619.0 19453.0 25294.0 True False 17214.016308462116 17340.201714263083 23482.286343547523 24995.7306808907 27624.87926605635 21747.917741306486 18823.431140564335 26696.45688298734 23344.143562233632 24563.696498295514 0.7007909542302236 0.705928023311407 0.9559752680211209 1.0175883211480474 1.1246222354185678 0.885368280902493 0.7663110127529259 1.0868257098372722 0.950351408382427 1.0 14.584240062345243 -5.270375255172889 5.215964868797456 0.9739286696075445 0.699950383181586 0.5661973757905887 0.09465489891871022 0.12336592464902515 11.347656846174258 0.026324787723038656 0.06291924489690089 5.365679707197612e-06 5.270375255172889 -0.27397828642595856 HSS(ph)ETFSSTTTVTPVSPSFAHNPK ddPTM_A459_Selumetinib_30min_R1 1 HSSETFSSTTTVTPVSPSFAHNPK 24 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 HS(0.205)S(0.702)ET(0.091)FS(0.002)STTTVTPVSPSFAHNPK 100.39 0.0002471 0.0 1073.0 883.95 850.49 886.88 1572.3 764.03 1087.3 706.23 272.19 721.89 True False 1097.998812305449 780.456723062794 734.9981294071657 732.003056799463 1430.0857426121102 756.3445518837354 1005.2840856097474 687.4984862416572 461.886550028958 814.551613304062 1.347979421281411 0.958142750337245 0.9023346309828006 0.8986576723238474 1.7556723469139786 0.9285409782883843 1.23415639867438 0.8440207778276446 0.5670439324960757 1.0 9.669862306448966 -7.874466901642837 5.328213400418991 0.7604743250781872 1.1345896623536345 0.2543707466473414 0.26842851344078866 0.2862439095202445 12.07936920007441 0.15216383199305542 0.07127370341920969 1.3351593405600199e-08 7.874466901642837 0.3741153372754472 HSS(ph)GDPSSEGTSGSGSVSIR ddPTM_A459_Selumetinib_30min_R1 2 HSSGDPSSEGTSGSGSVSIR 20 0 Q9UPU7;C9JW56;Q9UPU7-2 Q9UPU7 TBC1D2B TBC1 domain family member 2B 1 HS(0.004)S(0.411)GDPS(0.283)S(0.283)EGT(0.014)S(0.004)GSGSVSIR;HS(0.059)S(0.873)GDPS(0.063)S(0.002)EGT(0.003)SGSGSVSIR 149.24 1.6941e-05 6720300.0 3664.0 4390.6 3756.0 4162.5 4126.5 4107.1 4629.8 4645.5 2264.5699999999997 4013.7 True False 3749.364071097078 3876.546510865437 3245.9558302311757 3435.597514802188 3753.258803592745 4065.7863029484333 4280.5704585266385 4522.286249289349 3842.8098923512184 4528.897491748766 0.8278756756866488 0.8559581041364146 0.7167209759428224 0.7585946736620846 0.8287356493342667 0.8977430622697735 0.9451683254755586 0.9985402092956482 0.8485089140022409 1.0 12.14494417008249 -6.811691129138323 2.2556607811259775 0.9468091649948822 0.7896405512867896 0.653491136818978 0.05259623831905948 0.1945320249838632 2.029826392002432 0.021267156078569688 0.01899321988448951 1.5427973025287242e-07 6.811691129138323 -0.15716861370809265 HSS(ph)ISPVR ddPTM_A459_Selumetinib_30min_R2 1 HSSISPVR 8 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 HS(0.002)S(0.602)IS(0.397)PVR 75.652 0.036871 0.0 4766.8 3627.5 6652.5 9175.3 10429.0 8685.2 5969.0 8320.0 10274.0 9134.3 True False 4501.880339012305 3905.7175857491015 6224.485392694348 7925.608311724662 9118.815783557056 9881.50746360424 6246.570327349114 8344.209822549852 12329.08707954497 8870.569025238423 0.5075075033184022 0.44030068134711614 0.7017008012659083 0.8934723679140344 1.0279854378690167 1.1139654553715221 0.7041904876199551 0.9406622955989654 1.3898868318894106 1.0 13.114810937503954 -5.637457492997592 1.7901273185401747 1.0139253679764337 0.4626721788497875 0.6527394777954739 0.16127838073385165 0.23447733101684592 1.5021840689868056 0.05085821435346651 0.1222455937890925 2.3043185024737753e-06 5.637457492997592 -0.5512531891266462 HSS(ph)NPPLESHVGWVMDSR ddPTM_A459_Selumetinib_30min_R1 3 HSSNPPLESHVGWVMDSR 18 0 Q6PKG0;Q6PKG0-3;H0YC33;H0YBR8 Q6PKG0 LARP1 La-related protein 1 1 HS(0.313)S(0.687)NPPLESHVGWVMDSR;HS(0.073)S(0.927)NPPLESHVGWVMDSR;HS(0.031)S(0.969)NPPLESHVGWVMDSR 158.11 1.263e-05 59976000.0 5185.12 5725.41 6303.9 6019.0 6325.6900000000005 5213.6900000000005 5492.36 5139.0 2967.99 3981.39 True False 5305.923207512796 5055.076335529102 5447.865004844064 4967.894640623272 5753.532456391276 5161.245012251765 5078.066863275597 5002.697026175437 5036.46225658712 4492.44018852271 1.1810782080234197 1.1252406539421083 1.2126739091067422 1.1058343421722683 1.2807143144811157 1.1488733952291046 1.1303582574675222 1.1135812200586068 1.1210972311783423 1.0 12.133283580763226 -8.693706595454524 0.6579362638329764 0.9997931779957987 1.17569970515131 0.545865907555724 0.04714552024745161 0.7514134161649783 0.7027345402256954 0.047970796337875196 0.0186776729818253 2.0243863698234884e-09 8.693706595454524 0.17590652715551136 HSS(ph)NPPLESHVGWVMDSR ddPTM_A459_Selumetinib_30min_R2 5 HSSNPPLESHVGWVMDSR 18 0 Q6PKG0;Q6PKG0-3;H0YC33;H0YBR8 Q6PKG0 LARP1 La-related protein 1 1 HS(0.212)S(0.788)NPPLESHVGWVMDSR;HS(0.092)S(0.908)NPPLESHVGWVMDSR;HS(0.23)S(0.77)NPPLESHVGWVMDSR;HS(0.225)S(0.775)NPPLESHVGWVMDSR;HS(0.445)S(0.553)NPPLES(0.003)HVGWVMDSR 105.57 0.00089781 112085400.0 121913.0 119787.0 129841.0 132691.0 149847.0 112432.0 121828.0 109163.0 88495.0 136027.0 True False 115137.56351640656 128974.2777240875 121487.17142019207 114618.25689525751 131021.88021082325 127918.48744392207 127493.24339760219 109480.64625709246 106196.47275689416 132099.5470694092 0.8715969590411217 0.9763415589632599 0.9196637998793361 0.8676657826467302 0.9918420094353563 0.9683491751618931 0.9651300570365566 0.8287738200916612 0.8039124668693621 1.0 17.011265994452003 -7.75823186347513 24.986928971635617 0.8622573546984416 0.9386780923526299 0.14696583543907815 0.06263186698370561 118.27934681621674 921433.6468020616 0.030058082817505653 0.016410710591154176 1.744890332759173e-08 7.75823186347513 0.07642073765418833 HSS(ph)PHISR ddPTM_A459_Selumetinib_30min_R2 1 HSSPHISR 8 0 O60583-2;O60583 O60583-2 CCNT2 Cyclin-T2 1 HS(0.256)S(0.744)PHISR 71.221 0.045799 1281700.0 2582.9 932.18 3089.9 4066.8 5873.4 5275.0 5776.4 11337.0 6809.6 10813.0 True False 2439.352758167928 1003.6752085688762 2891.099198028751 3512.8948243786967 5135.53098313779 6001.583368317639 6045.014045719455 11369.988793058623 8171.710276121219 10500.800594452026 0.23230159798070363 0.09558082734178917 0.2753217882792888 0.334535904456151 0.48906089939952646 0.571535790469967 0.5756717301072517 1.0827735171988526 0.7781987861419486 1.0 13.358211704547012 -6.95032255480617 0.5858245800572233 1.0094206777699675 0.13411993243712736 0.8765127717982353 0.10956578684841203 0.26116900931768056 0.19131151191400678 0.09156723088421144 0.08890792281116272 1.121185429487207e-07 6.95032255480617 -0.8753007453328401 down HSS(ph)PSGTVAAR ddPTM_A459_Selumetinib_30min_R2 1 HSSPSGTVAAR 11 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 HS(0.03)S(0.966)PS(0.002)GT(0.002)VAAR 92.866 0.024405 575720.0 3865.8 3264.4 2998.5 3763.4 4443.9 2745.3 4205.9 2473.8 2912.6 2844.6 True False 3650.954312023532 3514.768983299622 2805.5797745199534 3250.8184277728883 3885.6175530299397 3123.440155647852 4401.4826838327435 2480.998348440363 3495.2013848435536 2762.4690068416007 1.321627248299071 1.272328838656599 1.0156058828430594 1.1767800542637146 1.4065741709343058 1.1306697551763516 1.5933147749103864 0.8981090257649441 1.2652454656277587 1.0 11.431742563129323 -10.471816499575873 6.593838193453068 0.9999999733068896 1.2274749456464118 0.12251089203051102 0.1853456444144381 7.008141425947963e-08 1.0934521076733507e-08 0.17280641396208005 0.04191170662432205 3.374298512058253e-11 10.471816499575873 0.22747497233952219 HSS(ph)PTEERDEPAYPR ddPTM_A459_Selumetinib_30min_R1 1 HSSPTEERDEPAYPR 15 1 F5H4R1;J3KNB8;F5H538;Q9Y6R4-2;Q9Y6R4 F5H4R1 MAP3K4 Mitogen-activated protein kinase kinase kinase 4 1 HS(0.122)S(0.877)PT(0.001)EERDEPAYPR 115.38 0.001309 19813000.0 916.32 1121.5 1333.5 1253.1 993.9 940.32 770.69 716.14 633.28 829.1 True False 937.6684731516576 990.1942586287944 1152.4180243911799 1034.269608600269 904.0019204872973 930.8612345422489 712.5562328139217 697.1456408494405 1074.6299070588145 935.5230611178963 1.0022932754123641 1.0584391767377377 1.2318435240004737 1.1055522323141627 0.9663063991250701 0.9950168769008465 0.7616661335557651 0.7451934322350018 1.1486941922892777 1.0 9.86962940684352 -6.528962739565316 2.0543080079351728 0.8997746264466074 1.1051138363956143 0.2868059056209924 0.12333580227203537 0.3771922115586638 3.2060963223622814 0.046491663251609555 0.050046258533827534 2.95826626106904e-07 6.528962739565316 0.2053392099490069 HSS(ph)TGDSADAGPPAAGSAR ddPTM_A459_Selumetinib_30min_R1 2 HSSTGDSADAGPPAAGSAR 19 0 F5H1N7;Q6ZU35 F5H1N7 KIAA1211 Uncharacterized protein KIAA1211 1 HSS(0.996)T(0.003)GDSADAGPPAAGSAR;HS(0.009)S(0.989)T(0.003)GDSADAGPPAAGSAR 195.38 3.3864000000000004e-15 3491140.0 538.3299999999999 549.42 599.1600000000001 723.56 619.83 435.98 554.27 209.32 234.65 269.175 True False 550.872041592164 485.09365098157133 517.7973629502959 597.2038289033686 563.7664859398744 431.59443703816765 512.4609676546629 203.76815363281614 398.18391184207695 303.72623323653306 1.8137124203004258 1.5971411024078208 1.7048160688413454 1.9662569891955426 1.8561665876942202 1.4209982207959448 1.687246314530801 0.6708941518203582 1.310996115149471 1.0 8.24662771114074 -7.742044357129835 23.86471562630979 0.9932091463436311 1.7186308333027283 0.7356707813323975 0.19967918143668 66.94947172257682 82378.58531051266 0.09349758714302107 0.053855770564541786 1.8111550989159136e-08 7.742044357129835 0.7254216869590971 HSS(ph)TGDSADAGPPAAGSAR ddPTM_A459_Selumetinib_30min_R2 2 HSSTGDSADAGPPAAGSAR 19 0 F5H1N7;Q6ZU35 F5H1N7 KIAA1211 Uncharacterized protein KIAA1211 1 HS(0.109)S(0.445)T(0.445)GDS(0.001)ADAGPPAAGSAR;HS(0.074)S(0.462)T(0.462)GDS(0.003)ADAGPPAAGSAR 118.36 0.00029908 7926700.0 14777.9 11358.6 15514.3 19191.2 15924.1 11287.1 13209.0 16533.1 11893.9 16794.1 True False 13956.603478620855 12229.768096344531 14516.126828692659 16577.32545333344 13923.572194739763 12841.795570907681 13823.244673136955 16581.20858379796 14273.012343332675 16309.210696687947 0.8557497807944282 0.749868790328899 0.8900569806018004 1.0164394685697415 0.8537244661121058 0.7873952829314772 0.8475728795351305 1.0166775628918234 0.8751504048096711 1.0 13.99339934237616 -14.522877544185643 0.028450535296777907 1.7983002734021845 0.33301899951516856 0.2358868113243534 0.07759783272147454 2571.6882727064726 5.493296116939334 215.9959055403657 91.4349810388722 3.0000082968796866e-15 14.522877544185643 -1.4652812738870158 HSS(ph)TPNSSEFSR ddPTM_A459_Selumetinib_30min_R2 1 HSSTPNSSEFSR 12 0 Q8N9Q2 Q8N9Q2 SREK1IP1 Protein SREK1IP1 1 HS(0.031)S(0.62)T(0.343)PNS(0.003)S(0.001)EFS(0.001)R 83.53 0.046896 0.0 5456.6 10099.0 10717.0 12023.0 14414.0 8707.2 7130.5 8072.5 7223.4 9741.1 True False 5153.344016500488 10873.560826596888 10027.479887787342 10385.446659168158 12603.184457205056 9906.537763908133 7462.082378817706 8095.989638525687 8668.281838659246 9459.849132582689 0.5447596409070367 1.1494433657662606 1.060004208021622 1.097844850759556 1.3322817605828123 1.0472194244395407 0.788816214110218 0.8558265068562836 0.9163234759001561 1.0 13.207601460043842 -7.190185561100109 8.272544765697447 0.8784539659325605 1.061127950115702 0.11634120028230344 0.19344409272637458 0.6424732887964021 69.14716903084876 0.07470978261328552 0.057786890137829165 6.453784191351414e-08 7.190185561100109 0.1826739841831415 HSS(ph)YPAGTEDDEGMGEEPSPFR ddPTM_A459_Selumetinib_30min_R1 2 HSSYPAGTEDDEGMGEEPSPFR 22 0 Q92934 Q92934 BAD Bcl2-associated agonist of cell death 1 HS(0.12)S(0.511)Y(0.369)PAGTEDDEGMGEEPSPFR;HS(0.197)S(0.802)YPAGTEDDEGMGEEPSPFR 151.23 1.3061e-07 22392600.0 4770.0 4411.1 5143.9 5707.7 5581.1 4925.3 5673.5 5628.6 3513.9 4498.4 True False 4881.131719195708 3894.6463613352466 4445.3866334201675 4710.957341798545 5076.290490423239 4875.755953814594 5245.543327238946 5479.3112437305 5962.831654898256 5075.813458126579 0.9616452140062047 0.7672950145754004 0.8757978736005215 0.9281186908585294 1.0000939814476233 0.9605861196510908 1.0334389493452767 1.079494210914687 1.1747538998604303 1.0 12.309423334144311 -6.653323323615864 0.7896292294562243 1.0906478890119515 0.854311794673275 0.6258260082486339 0.0644345502019163 0.3997229214262693 0.5517225059230033 0.04169475263728527 0.045194440966686567 2.221655296579601e-07 6.653323323615864 -0.23633609433867653 HSS(ph)YPAGTEDDEGMGEEPSPFR ddPTM_A459_Selumetinib_30min_R2 1 HSSYPAGTEDDEGMGEEPSPFR 22 0 Q92934 Q92934 BAD Bcl2-associated agonist of cell death 1 HS(0.162)S(0.838)YPAGTEDDEGMGEEPSPFR 188.49 7.7342e-22 9086500.0 18048.0 17235.0 18435.0 17509.0 20948.0 14805.0 18389.0 20757.0 16385.0 23548.0 True False 17044.964411868354 18556.869080740387 17248.912170510364 15124.243995290295 18316.324962503917 16844.25436359104 19244.124937112225 20817.399433493665 19662.457835151286 22868.108054948305 0.7453596235819817 0.8114737360935711 0.7542780596044091 0.6613683982491784 0.8009549770576909 0.736582769467289 0.8415267625494752 0.9103245175977337 0.859820051046883 1.0 14.48104939188188 -7.963274658087306 0.7699411113294075 0.9825590185708901 0.7459766151557446 0.7384025165674264 0.046999992664177564 0.3217352289722382 0.37823899738353695 0.04484138957599494 0.019249163553642312 1.088241645942743e-08 7.963274658087306 -0.23658240341514547 HSSAS(ph)FENVWLR ddPTM_A459_Selumetinib_30min_R2 2 HSSASFENVWLR 12 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 HS(0.002)S(0.002)AS(0.997)FENVWLR;HS(0.026)S(0.026)AS(0.948)FENVWLR 97.779 0.015889 24105000.0 48904.0 42449.0 49225.0 48927.0 44195.0 40412.0 56129.0 51795.0 47890.0 49656.0 True False 46186.11145822306 45704.70180495208 46057.91709212762 42263.05819621728 38642.828991687056 45978.38617638912 58739.10971750354 51945.71487487618 57469.33815840068 48222.30225821787 0.9577749152437489 0.9477917823212858 0.9551165111424891 0.8764214111949614 0.8013476582840191 0.9534672552585075 1.2180901152950123 1.0772134975373098 1.1917584907221423 1.0 15.5574129101503 -7.120900527705988 5.679462778269649 1.1269056633555519 0.9078799001432868 0.6743671681464442 0.0707401664200978 0.1340156947058815 5.691202612358859 0.027186452433864045 0.021011081042734837 7.570062624702251e-08 7.120900527705988 -0.21902576321226508 HSSETFSS(ph)TTTVTPVS(ph)PSFAHNPK ddPTM_A459_Selumetinib_30min_R2 1 HSSETFSSTTTVTPVSPSFAHNPK 24 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 2 HS(0.008)S(0.028)ET(0.044)FS(0.254)S(0.3)T(0.115)T(0.135)T(0.061)VT(0.055)PVS(0.924)PS(0.075)FAHNPK 74.766 0.0017747 6747500.0 27915.0 18644.0 29697.0 37598.0 41089.0 26214.0 23502.0 30012.0 20947.0 30781.0 True False 26363.596052598914 20073.934850091333 27786.32735164886 32477.087539832355 35927.03247967939 29824.740553000705 24594.889568329523 30099.329951245945 25136.9853080814 29892.27255135741 0.8819535552977467 0.6715426140853842 0.9295488425615562 1.0864710096575634 1.2018836111558182 0.9977408208679791 0.8227842003672841 1.0069267868320413 0.8409191795268817 1.0 14.867484961207246 -5.464126951244658 6.351594978030921 0.9968376856345389 0.7797301271028966 0.3661285655159473 0.11270559863542985 0.24622989018204453 20.763107070565276 0.03167586409446483 0.06587960892676575 3.4345753507669043e-06 5.464126951244658 -0.21710755853164232 HSSIS(ph)PVRLPLNSSLGAELSR ddPTM_A459_Selumetinib_30min_R1 3 HSSISPVRLPLNSSLGAELSR 21 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 HS(0.195)S(0.195)IS(0.61)PVRLPLNSSLGAELSR;HS(0.073)S(0.223)IS(0.704)PVRLPLNSSLGAELSR;HS(0.214)S(0.176)IS(0.61)PVRLPLNSSLGAELSR 71.001 0.0024556 25896800.0 2729.8999999999996 3364.34 3689.43 4049.9600000000005 4664.01 3231.33 3827.78 3306.7200000000003 1851.8799999999999 2869.39 True False 2793.5013585392785 2970.4415087607663 3188.425670588341 3342.710513164749 4242.151118997845 3198.8257540128957 3539.0474728366435 3219.0150438596693 3142.5051040362487 3237.70415672546 0.8628031541228158 0.9174530361554105 0.9847798057661457 1.0324323506275788 1.3102343245864252 0.9879919841867563 1.0930731473674713 0.9942276650487138 0.9705967413695099 1.0 11.660755450931259 -5.405053023848072 2.054009463721067 1.0637332728532995 0.8780923014271406 0.33718345937054395 0.09300814060792117 0.40197835903702966 3.2078089759448174 0.027752839741330266 0.08401220402398982 3.93502029103701e-06 5.405053023848072 -0.18564097142615898 HSSSPLS(ph)PGGPTHLTKPTTTSSSER ddPTM_A459_Selumetinib_30min_R2 2 HSSSPLSPGGPTHLTKPTTTSSSER 25 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 HS(0.007)S(0.04)S(0.1)PLS(0.829)PGGPT(0.019)HLT(0.002)KPT(0.001)TTSSSER;HS(0.029)S(0.144)S(0.133)PLS(0.694)PGGPTHLTKPTTTSSSER 57.688 0.0043851 11323600.0 19730.8 17699.9 41615.0 57434.0 77136.0 30726.0 25492.1 27647.0 42217.0 49454.0 True False 18634.2411246505 19057.425415851292 38937.53620698611 49611.39012082372 67445.48607541056 34958.22759714271 26677.533161637857 27727.44819279277 50661.57964153689 48026.1345230769 0.38800210155778025 0.3968136433444183 0.8107572386088316 1.033008186344564 1.4043496680542242 0.7279000890722328 0.5554794993717246 0.577340826367559 1.0548752287609913 1.0 15.551532074678855 -5.297843016511968 4.083927117797232 0.890113983224744 0.3831333735617615 0.4220882412909137 0.23691224632368216 0.2229308880449317 8.341088343157082 0.07033517064611985 0.17014602715113666 5.0368264096250055e-06 5.297843016511968 -0.5069806096629825 HST(ph)SGTDEGEDGDEPDDGSNDVVDLLPR ddPTM_A459_Selumetinib_30min_R1 1 HSTSGTDEGEDGDEPDDGSNDVVDLLPR 28 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 1 HS(0.095)T(0.38)S(0.295)GT(0.23)DEGEDGDEPDDGSNDVVDLLPR 160.84 2.4201e-17 7444600.0 572.26 406.97 558.24 619.66 627.66 365.44 604.95 599.69 144.33 341.14 True False 585.5925445758776 359.3217632047801 482.4340741928256 511.4480134588163 570.8882638223736 361.7640053929721 559.318134451961 583.7842731323502 244.91746855387606 384.9286419849946 1.521301562689911 0.933476296676274 1.2533078123389736 1.328682663938408 1.483101545466778 0.9398209588339089 1.453043690299784 1.5166038830519333 0.6362671982289733 1.0 8.588447213774431 -8.264799130461173 24.999989535726037 0.8181335843876515 1.2893149412667213 0.43508490947683187 0.22081730229404015 286.4977399253702 2131782.8283833326 0.18086277947506993 0.05416446464017353 5.435016533203793e-09 8.264799130461173 0.4711813568790698 HST(ph)SPASSEYSWK ddPTM_A459_Selumetinib_30min_R1 1 HSTSPASSEYSWK 13 0 Q96N46 Q96N46 TTC14 Tetratricopeptide repeat protein 14 1 HS(0.006)T(0.357)S(0.357)PAS(0.218)S(0.057)EYS(0.004)WK 153.81 0.00093942 3965500.0 1413.1 1548.9 1470.9 1821.2 2004.1 1701.0 1505.9 1420.2 694.79 1082.8 True False 1446.0224805860491 1367.554067935925 1271.159859075356 1503.1616081580173 1822.8295088525933 1683.8894843844269 1392.3087505929548 1382.5316825402515 1179.0078845461612 1221.7879273651652 1.1835298485101706 1.1193055990372327 1.0404095756754312 1.230296661548822 1.491936094657277 1.378217484940944 1.139566629697778 1.131564366920646 0.9649857050795544 1.0 10.25477817481847 -7.95850491410194 2.028359171988596 0.9848364746009606 1.2343723972552716 0.3899266613522462 0.12187558157747255 0.41729566180388 3.1843357367204894 0.11548776356613735 0.040054389767632266 1.1002593956385424e-08 7.95850491410194 0.24953592265431102 HST(ph)SPASSEYSWK ddPTM_A459_Selumetinib_30min_R2 1 HSTSPASSEYSWK 13 0 Q96N46 Q96N46 TTC14 Tetratricopeptide repeat protein 14 1 HS(0.001)T(0.981)S(0.019)PASSEYSWK 239.03 2.3828000000000003e-17 6459700.0 21005.0 16730.0 26923.0 30941.0 31531.0 22903.0 24879.0 23873.0 24309.0 30975.0 True False 19837.62618967723 18013.137204571332 25190.803491546023 26726.782423797897 27569.7938892835 26057.68035726616 26035.922796803254 23942.466477612095 29171.479250210094 30080.671267284863 0.6594808345002672 0.5988276340150048 0.8374415340572215 0.8885035239511231 0.9165285456667271 0.8662599356818866 0.865536628669567 0.7959418945431396 0.9697748760658946 1.0 14.876549141484459 -5.354876065475594 3.929277396110967 0.8881044077232327 0.628222526667023 0.7786795634315151 0.056588950903284314 0.09556018474245266 2.654337346733481 0.01450447605049062 0.0333357444571948 4.4169647619999704e-06 5.354876065475594 -0.2598818810562097 HSTENDS(ph)PTNVQQ ddPTM_A459_Selumetinib_30min_R1 1 HSTENDSPTNVQQ 13 0 B3KVN2;P49354-2;P49354 B3KVN2 FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1 HST(0.002)ENDS(0.997)PT(0.001)NVQQ 201.09 0.00010139 13329000.0 2245.2 2408.1 2408.9 2398.8 2924.8 2155.1 2360.8 2036.3 527.69 1208.0 True False 2297.5087916013 2126.158532504683 2081.784611140543 1979.894611052851 2660.2523564153794 2133.4216506742387 2182.722955309016 1982.2907091654079 895.4513890472869 1363.0585669164375 1.6855539793853547 1.5598438571238793 1.5272891874705241 1.4525381807561235 1.9516786886373507 1.565172401579593 1.6013420173476876 1.4542960642181508 0.6569427101529546 1.0 10.412631836815947 -8.142352776592498 4.3441634510818385 0.8354666924923584 1.6135310416307522 0.8125513232142794 0.14951849443466986 0.08981894341423954 2.6749814790276254 0.110508340621577 0.03846567957501743 7.205219627701841e-09 8.142352776592498 0.7780643491383938 HSTENDS(ph)PTNVQQ ddPTM_A459_Selumetinib_30min_R2 1 HSTENDSPTNVQQ 13 0 B3KVN2;P49354-2;P49354 B3KVN2 FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1 HST(0.001)ENDS(0.981)PT(0.017)NVQQ 188.48 0.0001488 30204000.0 14816.0 11838.0 16749.0 14899.0 21089.0 14955.0 11107.0 13398.0 10066.0 15525.0 True False 13992.58603314724 12745.936534830567 15671.38757493236 12869.730497791435 18439.611281947913 17014.915502026593 11623.497508102973 13436.985961841692 12079.481267539391 15076.752911205731 0.9280901607631515 0.8454032914048227 1.0394404993720279 0.8536142081512833 1.223049246117362 1.128553051325815 0.7709549646770333 0.891238719701688 0.8011991268067655 1.0 13.880038127564339 -7.271881935898301 24.99493654197206 0.8567847677609992 1.0007253941721266 0.22944018638807595 0.1226635289795188 1132.3307684585047 2710296.300132732 0.05337470819409955 0.036445440414174746 5.3470970188461376e-08 7.271881935898301 0.14394062641112737 HSTENDSPT(ph)NVQQ ddPTM_A459_Selumetinib_30min_R2 1 HSTENDSPTNVQQ 13 0 B3KVN2;P49354-2;P49354 B3KVN2 FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha 1 HSTENDS(0.019)PT(0.981)NVQQ 153.38 0.00096635 11399000.0 5787.0 5754.0 6546.1 8522.1 9184.2 7092.1 3712.8 5541.3 5460.6 7662.4 True False 5465.381707196483 6195.313297973906 6124.931052854781 7361.375278557511 8030.398688210257 8068.972399326172 3885.45255677363 5557.424265588404 6552.872581911937 7441.1666026939 0.7344791480972714 0.8325728516454715 0.8231143555685735 0.9892770410344659 1.0791854445649744 1.0843692703244932 0.5221563720085225 0.7468485201737679 0.8806243606398523 1.0 12.861313104917771 -10.081747667718654 9.678782423989055 1.0000052928313115 0.8575119396321308 0.06780302267744076 0.16129215296868638 0.0 0.0 0.1700825448822113 0.04125107633077728 8.284233515870102e-11 10.081747667718654 -0.14249335319918066 HSTPS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 3 HSTPSPTR 8 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 HST(0.026)PS(0.957)PT(0.017)R;HS(0.001)T(0.126)PS(0.865)PT(0.008)R;HS(0.009)T(0.173)PS(0.742)PT(0.076)R 97.597 0.019784 35292300.0 20815.6 15160.599999999999 17427.100000000002 20163.800000000003 25907.2 25712.8 33155.5 71319.0 34332.1 54688.0 True False 19658.75228344896 16323.36927098769 16305.85935919183 17417.45565550486 22652.505922693417 29254.504802441308 34697.296446376866 71526.52648250388 41199.479319023325 53109.01534351174 0.3701584779212188 0.3073559011668232 0.30702620362521743 0.32795666692082115 0.42652844862921835 0.5508387721599002 0.6533221567365359 1.3467869065142097 0.7757530252169628 1.0 15.696669161245273 -7.341661632759692 1.8049535962687093 1.0428324583724773 0.3477315476040512 0.7870588056045725 0.15177672404138398 0.14720871591906196 0.9339647294258036 0.0798574092411619 0.04646348269078401 4.5534268828875435e-08 7.341661632759692 -0.6951009107684261 down HSTPSNSSNPS(ph)GPPS(ph)PNSPHR ddPTM_A459_Selumetinib_30min_R2 1 HSTPSNSSNPSGPPSPNSPHR 21 0 Q9Y5S2 Q9Y5S2 CDC42BPB Serine/threonine-protein kinase MRCK beta 2 HSTPSNS(0.001)S(0.003)NPS(0.996)GPPS(0.923)PNS(0.078)PHR 97.295 0.0014128 0.0 612.3 435.32 753.32 2140.5 963.85 747.36 0.0 666.98 2376.5 725.49 True False 578.2708172311055 468.7076442255822 704.8522113528006 1848.9602074315421 842.7625460716723 850.3020561413978 0.0 668.9208013755169 2851.8664049580125 704.5432186506057 0.8207740872712584 0.6652645740076619 1.000438571678806 2.624338945413186 1.1961828937702286 1.2068841678299884 0.0 0.9494389892172754 4.047823227111776 1.0 9.460544397971043 -8.191463849637694 24.999876821854336 2.5239665986732907 1.0694345404379477 0.2883160873618671 0.9211590088758626 175.27054196965324 62617.92776437504 0.6122300725208769 0.23140115774604955 6.4348162571374855e-09 8.191463849637694 -1.454532058235343 HSTPSNSSNPSGPPS(ph)PNSPHR ddPTM_A459_Selumetinib_30min_R1 8 HSTPSNSSNPSGPPSPNSPHR 21 0 Q9Y5S2 Q9Y5S2 CDC42BPB Serine/threonine-protein kinase MRCK beta 1 HSTPSNSSNPSGPPS(0.987)PNS(0.013)PHR;HSTPSNSSNPSGPPS(0.897)PNS(0.103)PHR;HSTPSNSSNPSGPPS(0.991)PNS(0.009)PHR;HSTPSNSSNPSGPPS(0.951)PNS(0.049)PHR;HSTPSNSSNPSGPPS(0.931)PNS(0.069)PHR;HSTPSNSSNPS(0.016)GPPS(0.944)PNS(0.04)PHR;HSTPSNSSNPS(0.001)GPPS(0.904)PNS(0.095)PHR;HSTPSNSSNPS(0.001)GPPS(0.911)PNS(0.088)PHR 207.73 7.8986e-18 37549460.0 4893.332 5921.17 5183.38 6267.760000000001 10740.09 5160.68 9695.33 5325.360000000001 1172.068 2775.8100000000004 True False 5007.33711483341 5227.916663722746 4479.505466268283 5173.213376426805 9768.650755816903 5108.768244722533 8964.003452345032 5184.114153592841 1988.9137915402498 3132.1122521790708 1.5987093410683826 1.669134514602912 1.4301867575633043 1.651669212311181 3.118869941210014 1.6310935986308488 2.861967493696499 1.6551495400543683 0.6350071872923853 1.0 11.612920203153124 -8.127692751027723 4.683736918891093 0.838536011309025 1.9927042721773887 0.421491957453469 0.5418067070609827 0.22344276972588112 7.305085422422914 0.403532730336371 0.1435473805280622 7.452590335460754e-09 8.127692751027723 1.1541682608683637 HSTPSNSSNPSGPPS(ph)PNSPHR ddPTM_A459_Selumetinib_30min_R2 8 HSTPSNSSNPSGPPSPNSPHR 21 0 Q9Y5S2 Q9Y5S2 CDC42BPB Serine/threonine-protein kinase MRCK beta 1 HSTPSNSSNPS(0.001)GPPS(0.978)PNS(0.022)PHR;HSTPSNSSNPSGPPS(0.781)PNS(0.219)PHR;HSTPSNSSNPSGPPS(0.794)PNS(0.206)PHR;HSTPSNSSNPSGPPS(0.854)PNS(0.145)PHR;HSTPSNSSNPS(0.006)GPPS(0.917)PNS(0.076)PHR;HSTPSNSSNPS(0.009)GPPS(0.71)PNS(0.281)PHR;HSTPSNSSNPSGPPS(0.934)PNS(0.066)PHR;HSTPSNSSNPS(0.015)GPPS(0.895)PNS(0.089)PHR 136.3 2.2318e-05 37906270.0 3607.45 2093.33 5906.87 12102.830000000002 15450.94 5726.870000000001 3286.2900000000004 5397.67 10016.44 11812.5 True False 3406.962370766536 2253.8816798831626 5526.828415113782 10454.40367545373 13509.854784043839 6515.694359150191 3439.108996660096 5413.376326067626 12020.00788271729 11471.44243243914 0.296995115551665 0.1964776176280672 0.48179018878087404 0.9113416849733378 1.1776945108350492 0.5679925953099847 0.29979743322730934 0.4719002303284536 1.047820093550477 1.0 13.485759188452292 -5.529566312767943 4.464640669072289 0.7469957466108327 0.2597774626707749 0.4055181362150987 0.2611226339622596 0.22126952959785595 11.088314448474293 0.0783463521008645 0.15213397372721085 2.9541577813520647e-06 5.529566312767943 -0.4872182839400578 HSTPSNSSNPSGPPSPNS(ph)PHR ddPTM_A459_Selumetinib_30min_R2 1 HSTPSNSSNPSGPPSPNSPHR 21 0 Q9Y5S2 Q9Y5S2 CDC42BPB Serine/threonine-protein kinase MRCK beta 1 HSTPSNSSNPSGPPS(0.44)PNS(0.56)PHR 65.25 0.0053295 1381700.0 0.0 755.05 0.0 516.5 0.0 967.23 436.67 448.65 1170.7 1260.3 True False 0.0 812.9599071315946 0.0 446.15180898780295 0.0 1100.4571528602598 456.97602024519006 449.9554972219943 1404.8727120910348 1223.911864347348 0.0 0.6642307594306279 0.0 0.3645293603111804 0.0 0.8991310444131363 0.37337330698144094 0.36763717251971684 1.147854476302658 1.0 10.257283955889443 -8.00721540460582 0.7276410429160267 1.0678334160426446 0.2578182512377652 0.4645760390595892 0.29763755465650016 0.5946060701786271 0.6461701813847454 0.2720577786157631 0.11968620646564083 9.835231696325398e-09 8.00721540460582 -0.8100151648048795 HSTS(ph)GTDEGEDGDEPDDGSNDVVDLLPR ddPTM_A459_Selumetinib_30min_R1 1 HSTSGTDEGEDGDEPDDGSNDVVDLLPR 28 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 1 HS(0.02)T(0.087)S(0.511)GT(0.381)DEGEDGDEPDDGSNDVVDLLPR 198.02 2.4585e-40 7712200.0 500.47 540.51 661.02 880.59 811.55 600.15 837.12 745.34 239.77 483.67 True False 512.1299772549002 477.22683792371805 571.2571147229532 726.8114872215402 738.1454457907893 594.1130358926013 773.9753644308214 725.571161994473 406.87217789207244 545.7537558447628 0.9383902021199707 0.874436195468828 1.0467305238032016 1.3317571879950165 1.3525247199595112 1.0886100728211827 1.4181768904783774 1.329484505097677 0.7455233675163297 1.0 9.092106343566089 -5.531749103447493 5.021002539215989 1.2077250614252533 0.9155751350042957 0.23967045870100445 0.1921141788214385 0.219821608733247 15.982692194590635 0.05172013066166072 0.09819680131238788 2.9393472537998953e-06 5.531749103447493 -0.2921499264209576 HSTS(ph)PASSEYSWK ddPTM_A459_Selumetinib_30min_R1 1 HSTSPASSEYSWK 13 0 Q96N46 Q96N46 TTC14 Tetratricopeptide repeat protein 14 1 HS(0.005)T(0.229)S(0.757)PAS(0.007)S(0.002)EYS(0.001)WK 113.52 0.0045397 4292300.0 1555.9 1925.5 1865.7 2446.4 2658.5 1445.0 2279.6 1775.6 622.55 1232.4 True False 1592.1494427456187 1700.0615648593346 1612.348187556525 2019.1821646155145 2418.039144396298 1430.4646119550262 2107.647936683511 1728.5053200383531 1056.4218807470072 1390.5905445925648 1.1449448214190967 1.2225464724107145 1.159470121400066 1.4520321402063923 1.7388577491764623 1.0286741971010196 1.5156495525439087 1.2430009155173678 0.7596929842900182 1.0 10.441481969642858 -8.154032175426147 5.2339558463553875 0.8851816669485622 1.3257074641370616 0.4241184934672043 0.20316726103058047 0.20747038229648468 8.107287280877173 0.1463972318429143 0.052713107363298234 7.014033318671895e-09 8.154032175426147 0.4405257971884995 HSTS(ph)PASSEYSWK ddPTM_A459_Selumetinib_30min_R2 2 HSTSPASSEYSWK 13 0 Q96N46 Q96N46 TTC14 Tetratricopeptide repeat protein 14 1 HS(0.001)T(0.079)S(0.917)PAS(0.002)SEYSWK;HS(0.084)T(0.32)S(0.596)PASSEYSWK 119.88 0.0024929 4027600.0 39173.0 33525.0 45447.0 52638.0 55611.0 33839.0 40808.0 42455.0 34972.0 48540.0 True False 36995.92148194366 36096.25970013474 42522.98949895227 45468.613594385206 48624.649011352194 38500.01509014233 42705.65285951794 42578.5370211964 41967.37719932319 47138.5240779341 0.7848341076775829 0.7657486186978789 0.9020857214080151 0.9645744003187705 1.0315267599588203 0.8167420563802609 0.9059607549212341 0.9032641104927538 0.8902989225954243 1.0 15.52461896760763 -5.313921087038779 4.577552879391404 0.9250746032061529 0.7742644772704333 0.5313848540617856 0.05715520906674011 0.15757396914639385 7.155997380084964 0.015628944947959696 0.03562612544332827 4.853766869423464e-06 5.313921087038779 -0.15081012593571952 HSTSGT(ph)DEGEDGDEPDDGSNDVVDLLPR ddPTM_A459_Selumetinib_30min_R2 2 HSTSGTDEGEDGDEPDDGSNDVVDLLPR 28 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 1 HS(0.013)T(0.052)S(0.21)GT(0.725)DEGEDGDEPDDGSNDVVDLLPR;HS(0.049)T(0.042)S(0.187)GT(0.722)DEGEDGDEPDDGSNDVVDLLPR 115.67 5.7408e-12 7559800.0 3631.6000000000004 2614.3 4768.6 6993.200000000001 6315.5 5194.3 2643.78 5110.0 4269.7 3665.8 True False 3429.7702104466484 2814.808403700586 4461.793467659111 6040.714096057123 5522.090428713649 5909.767675839306 2766.7210085506867 5124.8692539939575 5123.759305385743 3559.9588291077625 0.9634297403676032 0.7906856620603293 1.2533272663654307 1.696849426084828 1.551166935854047 1.660066298384827 0.7771778105771279 1.4395866637812804 1.439274876858595 1.0 11.797644841194906 -5.383069277452284 4.64732312566302 1.3857767107670287 0.8814415743484747 0.33010575463753944 0.2725581452853166 0.2419756070972601 8.016111179736358 0.07403080823074437 0.1612577488997426 4.139336400058188e-06 5.383069277452284 -0.504335136418554 HSTSSLS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 HSTSSLSPQR 10 0 Q03164-2;Q03164;Q03164-3 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 HS(0.001)T(0.002)S(0.001)S(0.043)LS(0.953)PQR 83.53 0.026405 1569700.0 1039.0 2167.0 2151.4 3098.8 2377.0 952.97 2069.8 926.69 1165.9 2231.0 True False 981.2565394465435 2333.201931996777 2012.9812662672098 2676.7380942718373 2078.380009350383 1084.2329672996514 2166.049801230892 929.3865144782119 1399.1125779678287 2166.5852331658616 0.45290465587301637 1.0769029052170966 0.9291031967968312 1.235464016506994 0.9592883665663172 0.5004340243357731 0.9997528682801059 0.428963744537376 0.6457685377664163 1.0 11.081207277813274 -6.727254532370638 24.522991919928035 0.6970921424090989 0.9556924681980885 0.14794570090028303 0.2535818769161415 246.97032724153766 177166.82611962486 0.08163743624097078 0.08163283383595459 1.873895928667299e-07 6.727254532370638 0.2586003257889896 HSVT(ph)AAT(ph)PPPSPTSGESGDLLSNLLQSPSSAK ddPTM_A459_Selumetinib_30min_R2 1 HSVTAATPPPSPTSGESGDLLSNLLQSPSSAK 32 0 Q96QU8;Q96QU8-2 Q96QU8 XPO6 Exportin-6 2 HS(0.113)VT(0.507)AAT(0.773)PPPS(0.171)PT(0.16)S(0.139)GES(0.114)GDLLS(0.021)NLLQS(0.001)PS(0.001)S(0.001)AK 57.825 0.0085111 0.0 5556.9 4125.9 5117.9 4837.8 5483.3 5309.7 5977.5 5924.7 6604.2 4759.0 True False 5248.069744033203 4442.343263140518 4788.619885948197 4178.883294329513 4794.438832676042 6041.062978342402 6255.4655941915435 5941.9398961131155 7925.224536765711 4621.595304633049 1.1355537207622068 0.9612142496958064 1.0361400274809243 0.9042079669200532 1.0373991049951348 1.3071380292182588 1.3535295026634149 1.2856902226286344 1.7148244306075102 1.0 12.174175218729625 -6.78021897768177 3.730106576192693 1.3584431657587004 1.0028511675201905 0.4633378988083924 0.17061312116417424 0.18646187111464174 5.563408511758074 0.05836981788404278 0.053788492481688224 1.6587503301720113e-07 6.78021897768177 -0.35559199823850984 HSVTAAT(ph)PPPS(ph)PTSGESGDLLSNLLQSPSSAK ddPTM_A459_Selumetinib_30min_R2 1 HSVTAATPPPSPTSGESGDLLSNLLQSPSSAK 32 0 Q96QU8;Q96QU8-2 Q96QU8 XPO6 Exportin-6 2 HS(0.003)VT(0.003)AAT(0.442)PPPS(0.443)PT(0.443)S(0.437)GES(0.149)GDLLS(0.079)NLLQSPSSAK 69.492 0.0004768 4081100.0 11067.0 7670.4 8425.5 12972.0 14062.0 9928.3 11254.0 11975.0 11389.0 9710.2 True False 10451.940444711166 8258.695015776688 7883.412502990788 11205.19122205184 12295.40584412498 11295.833204865978 11777.333299377937 12009.845267432032 13667.118235247963 9429.841295870523 1.1083898569203108 0.8758042427917956 0.8360069120615062 1.188269332481637 1.3038825849072702 1.1978815815079096 1.248942896264375 1.2735999356310836 1.4493476407957162 1.0 13.203017775224467 -5.88032238851733 5.362775654253168 1.255912319435677 0.9354923983881296 0.5496824839158749 0.12375265011127423 0.14235758997954798 6.101742648374162 0.034068412881907546 0.05145673941092705 1.317278524116561e-06 5.88032238851733 -0.32041992104754735 HSVVAGGGGGEGR ddPTM_A459_Selumetinib_30min_R2 1 HSVVAGGGGGEGR 13 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 0 101.32 0.014347 927770.0 6727.5 4573.3 5083.1 4330.2 5652.0 4714.6 4881.8 7639.7 6124.1 6150.0 False True 6353.612482316289 4924.057404522777 4756.058880060823 3740.41928998835 4941.945230478908 5363.993355122343 5108.813373103183 7661.930262179582 7349.091121650902 5972.433520381018 1.0638230564868563 0.8244641631789383 0.7963351728957219 0.6262806069291711 0.8274592280708437 0.8981252510919772 0.8553989518124031 1.2828824692703789 1.2305019547847658 1.0 12.544103174683098 -7.7490078446926 22.73432136136481 1.19251907224131 0.8326275944301389 0.6027425551589272 0.12203328959220988 45.6173598178453 83424.37590183486 0.05952560569973027 0.033971098368360195 1.7823465725024246e-08 7.7490078446926 -0.35989147781117103 HSWDGLR ddPTM_A459_Selumetinib_30min_R2 1 HSWDGLR 7 0 Q86TI2-4;Q86TI2;M0R145;M0QXG6;M0R0I1;M0R3C4;M0R2G6;Q86TI2-2;M0R2A8 Q86TI2-4;M0R2A8 DPP9 Dipeptidyl peptidase 9 0 98.418 0.030727 760460.0 9109.4 7308.6 9055.2 6276.9 10346.0 5075.4 9124.3 5686.0 4541.3 6973.0 False True 8603.136015817463 7869.146119147046 8472.598290556309 5421.975391743541 9046.242985586474 5774.49028010604 9548.598029457444 5702.545318632026 5449.686894523802 6771.671371970217 1.270459764398517 1.1620685185225579 1.2511827324678941 0.8006849555911066 1.3358951562580732 0.852742249721128 1.4100799499783288 0.8421178473362435 0.804777224878563 1.0 12.725296245855931 -1.5228787455472983 0.19628308964043714 0.9193526790674906 2.5114413389725656 0.16971525003056598 0.2067153066167199 98.87128883348095 1.1803964023185975 0.38513565383105963 48.13615806409808 0.029999999981559007 1.5228787455472983 1.592088659905075 HSYIDTIPQSSRS(ph)PSYR ddPTM_A459_Selumetinib_30min_R1 1 HSYIDTIPQSSRSPSYR 17 1 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 HSYIDTIPQS(0.068)S(0.068)RS(0.699)PS(0.143)Y(0.022)R 59.339 0.035210000000000005 3554300.0 959.6 889.56 985.06 1046.8 1111.1 698.2 1126.1 673.64 533.32 852.58 True False 981.9568129434384 785.4099016547752 851.2942625472633 863.9960308696527 1010.6012011806376 691.1767419148781 1041.1573703716892 655.7728789088969 905.0050878483556 962.016947832464 1.020727145354249 0.8164200260966245 0.8849056811996173 0.8981089499684347 1.0505024921417856 0.7184662842709576 1.082265102207958 0.6816645802201609 0.940737156333303 1.0 9.909918499922304 -6.732864161221054 24.998048874448486 0.8770826215421567 0.9228569368690815 0.030797081281520144 0.1280083577071628 964.1366219593651 843439.5737000518 0.03982812711640023 0.039821066750165154 1.8498471243270908e-07 6.732864161221054 0.045774315326924886 HT(ph)EGAILY(ph)EKK ddPTM_A459_Selumetinib_30min_R1 1 HTEGAILYEKK 11 1 Q8N5H7-3;Q8N5H7-6;Q8N5H7-5;Q8N5H7-2;Q8N5H7-4;Q8N5H7 Q8N5H7-3 SH2D3C SH2 domain-containing protein 3C 2 HT(1)EGAILY(1)EKK 109.11 0.028278 15421000.0 1540.6 1323.4 1399.7 1609.6 1349.3 1293.1 1061.6 1046.1 481.92 1271.8 True False 1576.4929825142358 1168.455712768031 1209.6284280017517 1328.5135759340787 1227.2560532382638 1280.0925880408602 981.5226573009367 1018.3540297883094 817.7830419558228 1435.047918381064 1.0985646976114511 0.8142276629244642 0.8429184924823854 0.9257625190891389 0.8552021416976664 0.8920207971068902 0.6839650751232282 0.7096306797456325 0.5698646236694292 1.0 10.486883196097205 -7.253600630838199 23.267441703319182 0.7166676503257127 0.8965545570553264 0.28354851435304695 0.12489741983377434 264.9529324265017 786451.279465366 0.045800148178792174 0.03473936166068089 5.576983622855171e-08 7.253600630838199 0.17988690672961372 HT(ph)MT(ph)PIYPS(ph)SNTLVEMT(ph)LGMK ddPTM_A459_Selumetinib_30min_R1 1 HTMTPIYPSSNTLVEMTLGMK 21 0 A0A494C0X2;A0A494C167;A0A494C045;Q9UHD2 A0A494C0X2 TBK1 Serine/threonine-protein kinase TBK1 4 HT(0.955)MT(0.882)PIY(0.151)PS(0.505)S(0.504)NT(0.196)LVEMT(0.807)LGMK 44.089 0.036867 11987000.0 761.94 472.68 747.77 769.89 638.39 438.89 575.11 386.99 300.73 446.56 True False 779.6917195228458 417.33840585702984 646.2269412065936 635.4431641251787 580.6477372169089 434.47516508023614 531.7289896762825 376.7257680793212 510.3168455498313 503.88032586275176 1.5473748021176368 0.8282490592234505 1.282500840055848 1.261099375208117 1.1523524682626074 0.8622586411492074 1.0552684087552888 0.7476492904030049 1.0127739055420726 1.0 8.97693731678221 -6.665169525633476 5.222910266613757 0.9278938907612319 1.2045873325659768 0.36870234518042766 0.18291752794401808 0.23457668496369358 10.22052337576198 0.05834631516154977 0.05792488380105163 2.1618744773607005e-07 6.665169525633476 0.276693441804745 HT(ph)PSPGLPAEGAPEAPRPS(ph)SPPPEVLEPHSLDQPPATSPR ddPTM_A459_Selumetinib_30min_R2 1 HTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPR 40 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 2 HT(0.597)PS(0.558)PGLPAEGAPEAPRPS(0.422)S(0.422)PPPEVLEPHS(0.001)LDQPPATSPR 46.983 0.003734 4304800.0 8041.0 8125.6 10971.0 9707.3 9690.6 9169.2 9538.6 7896.8 4674.6 7706.7 True False 7594.113410673397 8748.807392077993 10265.137804321634 8385.148993973467 8473.180192936814 10432.174070289693 9982.163800377331 7919.778380614389 5609.650619237001 7484.18754658868 1.0146877484563868 1.1689722281299233 1.3715767730861477 1.120381997615152 1.132144289569403 1.3938953300341488 1.333767190926053 1.058201485640783 0.7495336780802481 1.0 12.869629996252977 -8.006671540772953 5.528214711823735 0.8798626927602394 1.2220201086016051 0.5433500189152076 0.12661371987883974 0.12392077912870901 12.97017707677615 0.08161848375401495 0.03391312322373488 9.847556000922423e-09 8.006671540772953 0.3421574158413657 HT(ph)PYGNQTDYR ddPTM_A459_Selumetinib_30min_R2 1 HTPYGNQTDYR 11 0 A0A6E1WJ75;Q86U70-3;Q86U70-2;Q86U70 A0A6E1WJ75 LDB1 LIM domain-binding protein 1 1 HT(1)PYGNQTDYR 112.08 0.010677 4769300.0 34422.0 9451.5 19479.0 19863.0 19769.0 27559.0 18272.0 23400.0 14894.0 17559.0 True False 32508.96304218376 10176.399658637529 18225.742347131618 17157.625134413796 17285.441482897655 31355.002094306346 19121.684205281133 23468.090125921473 17873.216173130506 17052.02604623907 1.9064575056378017 0.5967853691428062 1.0688314865171942 1.0061927590239648 1.013688428344271 1.8387845531834552 1.1213731525761153 1.3762640323375244 1.048157921215031 1.0 14.057655543620472 HTDDEMT(ph)GYVATR ddPTM_A459_Selumetinib_30min_R2 1 HTDDEMTGYVATR 13 0 Q16539-5;Q16539-3;Q16539-4;Q16539-2;Q16539;E7EX54;B4E0K5 Q16539-5 MAPK14 Mitogen-activated protein kinase 14 1 HTDDEMT(0.746)GY(0.253)VAT(0.001)R 101.45 0.023628 18826000.0 8278.9 10063.0 11272.0 9287.2 9319.5 6636.1 8268.9 8066.2 7073.7 6092.6 True False 7818.7918810625515 10834.799742355131 10546.771792025647 8022.26733868639 8148.7010926129105 7550.162538482025 8653.420234514502 8089.6713065687 8488.637655691771 5916.690807524125 1.3214805598966852 1.8312262876026504 1.782545705889101 1.355870637770128 1.377239635752199 1.276078602735274 1.4625439313999877 1.36726281121218 1.4346934683314798 1.0 12.53057478983845 -11.692374781668224 0.08187293240620515 3.799131581343903e-14 2.0317067130644664 0.4521321207714786 0.16847956755532442 112.44916438480655 1.2292141745260932 28.81304236126578 7.2468311135422505 2.030603911091255e-12 11.692374781668224 2.031706713064428 HTDDEMTGY(ph)VATR ddPTM_A459_Selumetinib_30min_R1 1 HTDDEMTGYVATR 13 0 Q16539-5;Q16539-3;Q16539-4;Q16539-2;Q16539;E7EX54;B4E0K5 Q16539-5 MAPK14 Mitogen-activated protein kinase 14 1 HTDDEMT(0.001)GY(0.999)VATR 181.4 0.0016066 12889000.0 1333.0 2155.5 1743.7 1950.8 1571.5 1671.1 1946.2 1634.6 701.7 1185.3 True False 1364.0563064335165 1903.1330579352357 1506.9151174584938 1610.1294010513166 1429.3581024708603 1654.2902512374005 1799.3965671053904 1591.2450980709027 1190.7336498597294 1337.4448007997137 1.0198972739793752 1.4229619471377613 1.1267120082693856 1.2038847510480832 1.0687230617788397 1.2369035718320724 1.345398752927565 1.189765063290411 0.8903048926936951 1.0 10.385263634302333 -8.23725481468237 10.442852372934281 0.9451764568182931 1.2083145720542396 0.43994643470564687 0.11563192672664813 0.4754360540339562 205.2208101292648 0.07738634386523682 0.028428825312180248 5.790888265016841e-09 8.23725481468237 0.26313811523594655 HTDDEMTGY(ph)VATR ddPTM_A459_Selumetinib_30min_R2 2 HTDDEMTGYVATR 13 0 Q16539-5;Q16539-3;Q16539-4;Q16539-2;Q16539;E7EX54;B4E0K5 Q16539-5 MAPK14 Mitogen-activated protein kinase 14 1 HTDDEMTGY(0.997)VAT(0.003)R;HTDDEMTGY(0.994)VAT(0.006)R 149.57 0.0033675 70421000.0 101813.0 88956.0 112876.0 123163.0 143680.0 49231.0 90409.0 94781.0 72161.0 87605.0 True False 96154.64104973148 95778.63916137783 105613.68105009645 106387.9869319743 125629.63388450273 56012.12337547791 94613.19764203475 95056.79701816088 86595.21634680222 85075.61602487466 1.1302256221291127 1.125806002196608 1.2414095364201279 1.2505109207891985 1.4766820359875006 0.6583804619069807 1.1121071120351507 1.1173212896909015 1.0178617610183776 1.0 16.376458072202432 -6.746151821101938 24.999843809350587 0.9966523991700936 1.2384237317549793 0.4350281628233438 0.14969693149704333 262.51967227072447 429299.3606112282 0.050669914163572166 0.05048806009625819 1.7941063316971547e-07 6.746151821101938 0.2417713325848857 HTENTFSR ddPTM_A459_Selumetinib_30min_R2 2 HTENTFSR 8 0 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4;E9PGZ1;C9J813 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 0 ; 141.52 0.0031935 1296100.0 4574.6 1329.3 1248.25 2923.44 5146.1 3223.7 5969.0 8543.599999999999 5743.8 5902.4 False True 4320.362045574744 1431.2530356268187 1167.9389539918402 2525.2624287847084 4499.600911282288 3667.735413165041 6246.570327349114 8568.460461530882 6892.720495181077 5731.982375723073 0.7537291223840762 0.24969599377846485 0.20375829467628256 0.44055655849188713 0.7849990834479277 0.6398720674193221 1.0897748663369062 1.4948511526869437 1.2025020391503873 1.0 12.484818458376589 -7.034382384482941 1.2628949113211039 1.2745684258172458 0.40494457153744645 0.7326224685470224 0.20569178328993223 0.22291074480175269 0.7220560794500611 0.11919182089682505 0.08372723339837164 9.238843606612222e-08 7.034382384482941 -0.8696238542797994 HTFPPFIS(ph)EIAK ddPTM_A459_Selumetinib_30min_R2 1 HTFPPFISEIAK 12 0 Q7L8W6-2 Q7L8W6-2 1 HT(0.001)FPPFIS(0.999)EIAK 80.69 0.039662 2356900.0 27610.0 24231.0 28862.0 28523.0 27482.0 19105.0 18789.0 21634.0 15913.0 25901.0 True False 26075.546731587172 26089.439785054852 27005.050342569586 24638.118195080544 24029.465467802773 21736.54033207746 19662.725729697195 21696.9513582985 19096.044646369395 25153.1708311201 1.0366703628206542 1.0372227008762003 1.073624097887424 0.9795233515687684 0.9553254986871456 0.8641670061408121 0.7817195637764287 0.8625930903094935 0.7591903531599012 1.0 14.618452658466332 -6.481940629303828 1.5575380457397963 0.8369112518182096 1.0442762824708194 0.6417239103384396 0.06314398414530745 0.21716461923101318 1.0686521305541494 0.023511510903610814 0.02675601489961256 3.296547749092326e-07 6.481940629303828 0.2073650306526098 HTGMASIDSSAPETTS(ph)DSSPTLSR ddPTM_A459_Selumetinib_30min_R1 1 HTGMASIDSSAPETTSDSSPTLSR 24 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2;H0YCW2;S4R3B3;H7C453;S4R3U7 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 HTGMASIDSSAPET(0.001)T(0.039)S(0.466)DS(0.229)S(0.229)PT(0.008)LS(0.027)R 140.19 2.9535e-08 6690900.0 1918.1 3267.4 2389.8 2512.8 2750.9 2139.8 3003.6 2084.0 744.05 2061.6 True False 1962.7879980271032 2884.8512890269494 2065.278286231753 2073.9866510978823 2502.081580710841 2118.27555478295 2777.036033787768 2028.7255502139717 1262.5985067381107 2326.2264416845433 0.843764804171749 1.240142076167734 0.8878234075682573 0.8915669661101432 1.0755967415188317 0.9106059138632244 1.1937943718741197 0.87211008948246 0.5427668107081598 1.0 11.183775824463126 -7.998234554500726 24.981245813149183 0.7500683979759477 1.0071972448097906 0.2569135886222734 0.16212974725395596 59.80815830451175 846297.1247452454 0.08338520121613567 0.039610225375971204 1.0040733621686141e-08 7.998234554500726 0.25712884683384285 HTGMASIDSSAPETTSDS(ph)SPTLSR ddPTM_A459_Selumetinib_30min_R1 1 HTGMASIDSSAPETTSDSSPTLSR 24 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2;H0YCW2;S4R3B3;H7C453;S4R3U7 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 HTGMASIDSSAPETT(0.014)S(0.131)DS(0.399)S(0.248)PT(0.052)LS(0.155)R 130.26 7.7689e-08 8414900.0 3043.2 4104.0 3069.6 3454.1 3646.6 3571.0 3635.4 3445.0 1252.7 2481.9 True False 3114.1006389635977 3623.5017721021604 2652.7651801058637 2850.9062764872633 3316.7656738595206 3535.078982208581 3361.1788511226678 3353.6274090629236 2125.740406411976 2800.476040753236 1.111989745188467 1.293887795993269 0.9472550885999929 1.0180077368990679 1.1843578111696396 1.262313596247644 1.2002169639054014 1.1975204787543579 0.7590639503704598 1.0 11.451456370139162 -8.251647156184232 24.981512654511874 0.8795319707569775 1.1517562273645636 0.4807409192233051 0.11324568380904883 522.3008864359391 1332481.0162837096 0.0815329641001526 0.02996873081537215 5.602125629798966e-09 8.251647156184232 0.2722242566075861 HTGMASIDSSAPETTSDS(ph)SPTLSR ddPTM_A459_Selumetinib_30min_R2 2 HTGMASIDSSAPETTSDSSPTLSR 24 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2;H0YCW2;S4R3B3;H7C453;S4R3U7 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 HTGMASIDSSAPET(0.001)T(0.013)S(0.178)DS(0.36)S(0.241)PT(0.045)LS(0.162)R;HTGMASIDSSAPETTS(0.005)DS(0.59)S(0.34)PT(0.009)LS(0.055)R 186.68 2.5024e-26 20688000.0 33132.0 26051.7 45001.0 46460.0 56201.0 35092.0 28491.0 35520.0 28400.0 45226.0 True False 31290.656077904616 28049.78162058166 42105.68465338417 40132.06785202964 49140.527936685234 39925.60446654079 29815.88795384546 35623.35731934746 34080.79356230066 43920.20786874015 0.712443260091569 0.6386532072983622 0.9586859146755665 0.9137494970872693 1.1188591839898965 0.9090486225808032 0.6788649098144791 0.8110926393110742 0.775970679923794 1.0 15.422597262000277 -5.256315694710045 24.971883729523476 0.8903724723055348 0.6755482156955566 0.3615685363103218 0.11688344290746353 499.4752471735355 2434329.391883893 0.03308449126739357 0.08205855619210742 5.542226942970891e-06 5.256315694710045 -0.21482425660997828 HTGPGILS(ph)MANAGPNTNGSQFFICTAK ddPTM_A459_Selumetinib_30min_R1 1 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 HT(0.017)GPGILS(0.699)MANAGPNT(0.249)NGS(0.035)QFFICTAK 67.064 0.0007069 12120000.0 702.29 2938.4 1837.8 2154.7 1779.0 1730.8 1818.9 1836.0 557.96 1044.3 True False 718.6519905815417 2594.370761974902 1588.2368543127952 1778.4220937283549 1618.08976410796 1713.3897234406638 1681.6989085952093 1787.303315831503 946.817368213959 1178.346077343407 0.6098819391003956 2.201705264572134 1.3478526256848846 1.5092527805904232 1.3731872114820118 1.4540632471094723 1.4271689284922273 1.516789804113403 0.8035138287629117 1.0 10.202547602048345 -8.259173111053743 24.918925818647192 0.9017568734202757 1.454431191834222 0.25119597118884585 0.3628474039552124 225.8443311899886 2483366.8216217323 0.251299681885103 0.08456575877554863 5.505881865943025e-09 8.259173111053743 0.5526743184139464 HTGPGILS(ph)MANAGPNTNGSQFFICTAK ddPTM_A459_Selumetinib_30min_R2 1 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 HT(0.051)GPGILS(0.833)MANAGPNT(0.087)NGS(0.028)QFFICTAK 58.99800000000001 0.0040605 3058100.0 9826.0 7468.7 9148.4 10405.0 12936.0 6889.6 7710.3 8732.1 6706.2 8955.5 True False 9279.910256594554 8041.525274344408 8559.801904024798 8987.821050373837 11310.864030692699 7838.579862438149 8068.844227669609 8757.508965323024 8047.6273868838325 8696.931445816614 1.067032701638503 0.9246393770543669 0.9842324223611332 1.033447383869761 1.3005580302847433 0.9013040876858529 0.9277805945625653 1.0069653900210458 0.9253410167737831 1.0 13.086290746680655 HTGPGILSMANAGPNTNGS(ph)QFFICTAK ddPTM_A459_Selumetinib_30min_R1 1 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 HTGPGILSMANAGPNT(0.369)NGS(0.63)QFFICT(0.001)AK 89.23899999999998 2.4323e-05 9582400.0 738.13 2725.6 1346.2 1828.9 1404.9 1327.7 1097.7 1369.7 412.25 780.03 True False 755.3269928490407 2406.485484902938 1163.3934341472868 1509.516947704919 1277.8270430552407 1314.3445434551475 1014.8996052366605 1333.371106587369 699.5581404512953 880.1544486356202 0.8581755100140869 2.7341627240916346 1.3218060034244357 1.7150591581340195 1.4518213763914691 1.4933112540561388 1.1530926268791992 1.5149285544762139 0.7948129348612872 1.0 9.781612898444228 -7.316529663465926 0.5897849859531016 0.9575802802199531 1.7532879934087606 0.22237839080369903 0.46583740436942994 1.1510569262685326 0.8212366273802907 0.40219936965050224 0.29405446206868413 4.824700249508666e-08 7.316529663465926 0.7957077131888075 HTGPNS(ph)PDTANDGFVR ddPTM_A459_Selumetinib_30min_R1 10 HTGPNSPDTANDGFVR 16 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;E5RGH4;H0YAQ2;E7EQJ0;P55795 P31943;E7EQJ0;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 1 HT(0.004)GPNS(0.996)PDTANDGFVR;HTGPNS(1)PDTANDGFVR;HTGPNS(0.997)PDT(0.003)ANDGFVR;HTGPNS(0.999)PDT(0.001)ANDGFVR;HTGPNS(0.993)PDT(0.006)ANDGFVR;HTGPNS(1)PDTANDGFVR;HT(0.004)GPNS(0.965)PDT(0.03)ANDGFVR;HTGPNS(1)PDTANDGFVR;HT(0.049)GPNS(0.946)PDT(0.004)ANDGFVR;HT(0.001)GPNS(0.999)PDTANDGFVR 317.7 2.5742999999999987e-117 1602916900.0 17487.420000000002 20882.739999999998 22272.65 23182.0 21089.559999999998 16665.66 20279.25 17249.769999999997 10627.119999999999 15182.190000000002 True False 17894.84286140406 18437.779092677552 19248.14646490905 19133.69888003468 19182.013021664236 16498.01859160857 18749.56984558216 16792.250064450316 18033.446465864814 17130.97197355387 1.0445900494746838 1.0762833026135983 1.123587528753394 1.1169067878677603 1.1197270681007874 0.9630521033527794 1.0944837149069542 0.9802275136736864 1.052680869112631 1.0 14.06431938862721 -6.743224161982927 24.99997334961591 1.0216277250473995 1.0977812220618821 0.4764080242193507 0.04085337256019776 219.79782537355354 301666.9069306126 0.013154956785275635 0.013130117275784496 1.8062415900844657e-07 6.743224161982927 0.0761534970144826 HTGPNS(ph)PDTANDGFVR ddPTM_A459_Selumetinib_30min_R2 11 HTGPNSPDTANDGFVR 16 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;E5RGH4;H0YAQ2;E7EQJ0;P55795 P31943;E7EQJ0;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 1 HTGPNS(0.998)PDT(0.002)ANDGFVR;HTGPNS(0.999)PDTANDGFVR;HTGPNS(1)PDTANDGFVR;HTGPNS(1)PDTANDGFVR;HTGPNS(1)PDTANDGFVR;HT(0.005)GPNS(0.995)PDTANDGFVR;HTGPNS(1)PDTANDGFVR;HT(0.001)GPNS(0.966)PDT(0.032)ANDGFVR;HTGPNS(1)PDTANDGFVR;HT(0.006)GPNS(0.994)PDTANDGFVR;HTGPNS(1)PDTANDGFVR 258.13 5.8813e-39 1733760000.0 592176.3 578244.0 636861.0 630071.0 676979.0 527413.0 508692.0 554430.0 462055.0 571772.0 True False 559265.5119155517 622593.455452488 595886.056621827 544254.2428669006 591930.8457509521 600059.3533714717 532347.1859540754 556043.2995091727 554478.9108953826 555263.4567179328 1.0072074888941447 1.121257752369535 1.0731591452893503 0.9801729904645521 1.0660360205401487 1.0806750311254405 0.9587290132519948 1.0014044554558827 0.9985870746344672 1.0 19.082812926108176 -7.258199992290312 24.988385018892934 0.9897971735358688 1.0557341455551517 0.40908355956385445 0.038302475633837964 298.66137486640537 2303864.595855655 0.015450391236219356 0.011448692835202454 5.5182326655264875e-08 7.258199992290312 0.06593697201928284 HTGPNS(ph)PDTANDGFVRL ddPTM_A459_Selumetinib_30min_R1 1 HTGPNSPDTANDGFVRL 17 1 E7EQJ0 E7EQJ0 HNRNPH1 1 HT(0.001)GPNS(0.996)PDT(0.003)ANDGFVRL 106.28 0.004609899999999999 2762000.0 582.37 377.19 618.57 522.53 1065.6 376.93 1377.1 554.81 485.57 947.91 True False 595.938087905242 333.02841944912626 534.5715915617944 431.279944602904 969.2166681469602 373.1384264250573 1273.224238290429 540.0946365231354 823.9768253703702 1069.583481925299 0.5571683725262158 0.31136271742871335 0.49979417277419164 0.40322233083347586 0.9061627114905757 0.34886330308073854 1.1903925778645787 0.5049579071200131 0.7703716814017867 1.0 10.062833375168156 -6.35696477230482 1.0640418926060207 0.7951035908256125 0.41594649786321664 0.3114219027875901 0.2366186308032416 0.6439067561535247 1.537344337609149 0.10288016128358561 0.14129257737186793 4.3957727019905673e-07 6.35696477230482 -0.3791570929623959 HTGPNS(ph)PDTANDGFVRL ddPTM_A459_Selumetinib_30min_R2 4 HTGPNSPDTANDGFVRL 17 1 E7EQJ0 E7EQJ0 HNRNPH1 1 HTGPNS(1)PDTANDGFVRL;HTGPNS(1)PDTANDGFVRL;HT(0.084)GPNS(0.915)PDTANDGFVRL;HT(0.004)GPNS(0.996)PDTANDGFVRL 143.33 0.00025494 27477500.0 38831.0 157583.0 155969.0 115142.0 105058.0 20009.1 23802.300000000003 20324.2 21551.8 83004.0 True False 36672.92847280916 169669.10939079293 145934.12434620722 99459.46096897096 91859.6748095634 22765.171900474797 24909.15411336267 20383.34005714757 25862.76220760535 80607.45884970845 0.4549570101345752 2.1048810099216597 1.8104295362827338 1.2338741648513176 1.1395927389403822 0.28242016589209396 0.3090179800830276 0.2528716367942083 0.3208482512248169 1.0 16.29862572137469 -6.580662819956804 2.4793680142509142 0.37313711546412 1.4809860229685252 0.5027719000170433 0.4537965607321356 0.21624487122892663 2.6962848141746005 0.16026510909317412 0.1655701238806696 2.6262567403542545e-07 6.580662819956804 1.1078489075044051 HTGPNSPDT(ph)ANDGFVR ddPTM_A459_Selumetinib_30min_R1 1 HTGPNSPDTANDGFVR 16 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;E5RGH4;H0YAQ2;E7EQJ0;P55795 P31943;E7EQJ0;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 1 HTGPNS(0.01)PDT(0.99)ANDGFVR 134.75 0.00099453 605260000.0 1959.6 2129.5 2318.1 2754.9 2326.6 2040.0 2013.6 1829.3 1078.0 1587.2 True False 2005.254867282159 1880.1771500223078 2003.314752411846 2273.8084308777306 2116.159440794591 2019.4794521718018 1861.7125308413385 1780.7810215961704 1829.2872659951393 1790.9325806372274 1.1196707731838091 1.0498313394652337 1.1185874745207056 1.2696225728769155 1.181596372567886 1.1276133306220024 1.0395212812416015 0.9943316911251651 1.021416040878694 1.0 10.806495312990382 -7.303890429281814 2.927729613769709 1.0072047703345046 1.1481384110491188 0.6020632696589323 0.05271617102320171 0.217287140921248 3.7191396460744053 0.027738979338665877 0.01825374703178625 4.967176254643438e-08 7.303890429281814 0.14093364071461423 HTGPNSPDT(ph)ANDGFVR ddPTM_A459_Selumetinib_30min_R2 1 HTGPNSPDTANDGFVR 16 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;E5RGH4;H0YAQ2;E7EQJ0;P55795 P31943;E7EQJ0;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 1 HTGPNS(0.461)PDT(0.539)ANDGFVR 95.755 0.019937 472070000.0 64979.0 81577.0 87847.0 94933.0 87711.0 64846.0 64121.0 54960.0 49371.0 85745.0 True False 61367.72731154664 87833.69358860217 82195.01966058165 82002.96163144075 76691.96003371113 73777.947886621 67102.75355335107 55119.92450088223 59246.57954099812 83269.31905773495 0.7369788537480078 1.054814601374397 0.9870984966694824 0.9847920285571669 0.921011014639577 0.8860159866981369 0.8058520750821229 0.6619475831508208 0.7115055126116666 1.0 16.345497405791576 -7.139654496074619 2.169451644551477 0.7622250815942749 0.9488183111162333 0.2423431337352726 0.11374757873939162 0.3613390502308297 3.3361390523951386 0.050970239585419276 0.036194940710321644 7.250125159979592e-08 7.139654496074619 0.18659322952195834 HTGPNSPDTANDGFVR ddPTM_A459_Selumetinib_30min_R1 3 HTGPNSPDTANDGFVR 16 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIT2;D6RIU0;D6R9T0;D6RFM3;D6RDU3;D6RJ04;D6RIH9;D6RAM1;E5RGH4;H0YAQ2;E7EQJ0;P55795 P31943;E7EQJ0;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 0 ;; 283.05 1.1474999999999999e-61 35628000.0 4831.6900000000005 5435.14 5705.6 6170.700000000001 6293.0 5153.3 6086.2 4812.86 2922.4300000000003 4025.8999999999996 False True 4944.258976167864 4798.7912820719675 4930.810858617412 5093.10308338495 5723.799261119389 5101.462480822028 5627.113033972267 4685.207318427458 4959.150264157864 4542.663480586829 1.0884052929074015 1.056382737259695 1.0854448892570052 1.1211711158333513 1.26000952647718 1.1230113132137651 1.2387254873753815 1.031378912052322 1.0916833891286246 1.0 12.14932271951508 -7.826393906684867 24.99995307709489 1.046147665380675 1.137135661645706 0.3240095591389527 0.06470070432552931 85.68556063557538 32977.12022380425 0.03765322617875195 0.018088029512565166 1.491441053427247e-08 7.826393906684867 0.09098799626503107 HTLGDS(ph)DNES ddPTM_A459_Selumetinib_30min_R2 1 HTLGDSDNES 10 0 G3V192;G3V1D1;P02794 G3V192 FTH1 Ferritin;Ferritin heavy chain;Ferritin heavy chain, N-terminally processed 1 HTLGDS(1)DNES 89.266 0.035586 0.0 25607.0 15919.0 19354.0 23725.0 26542.0 23462.0 24877.0 25609.0 18418.0 18818.0 True False 24183.865452942868 17139.93611234735 18108.78471104192 20493.614072092194 23207.55667150941 26693.67753316937 26033.829792840326 25683.51795020184 22102.114641917382 18274.675444964225 1.3233540330592837 0.9379064577078678 0.9909223704452701 1.1214215067080395 1.269929895138274 1.460692290462816 1.4245850697181173 1.4054158186037278 1.2094395169139842 1.0 14.157558163943389 -6.276741393972183 3.2315225827515968 1.3350135091316033 1.0692226201584867 0.26921013662099236 0.15700338687486406 0.26796720201405005 5.80961303455169 0.048951294575015465 0.060113764142754385 5.287600147503932e-07 6.276741393972183 -0.26579088897311665 HTLQQHQET(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 HTLQQHQETPK 11 0 Q7Z417;Q7Z417-2 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 HTLQQHQET(1)PK 89.46600000000002 0.036503 0.0 2601.6 2903.0 2658.6 2528.2 2202.0 2636.9 2174.0 1966.4 1621.7 2752.8 True False 2662.2122181676195 2563.115410431913 2297.5767226444646 2086.697330191687 2002.8294887946763 2610.3751801136373 2010.0134297025577 1914.2446842326092 2751.9064557182896 3106.14869454269 0.8570781633361471 0.8251747300234362 0.7396866501211496 0.6717956979515772 0.6447951098778765 0.8403896390085588 0.647107922822248 0.61627593282827 0.8859545135599007 1.0 11.600911179340487 -8.4979238266851 5.647401506538984 0.9997545243087025 0.7303866956461729 0.5366181919077231 0.08248254112794277 0.11997399076932262 12.825070403244546 0.08407468041202537 0.021815217134249183 3.1774313290598085e-09 8.4979238266851 -0.2693678286625296 HTNPSS(ph)SSPGTR ddPTM_A459_Selumetinib_30min_R2 1 HTNPSSSSPGTR 12 0 Q8WUH2 Q8WUH2 TGFBRAP1 Transforming growth factor-beta receptor-associated protein 1 1 HTNPS(0.085)S(0.277)S(0.277)S(0.277)PGT(0.085)R 111.66 0.0044346 2450100.0 497.75 0.0 0.0 743.86 757.98 0.0 1066.6 2305.8 1080.6 1203.1 True False 470.08704765112304 0.0 0.0 642.5449847699268 662.7557759728244 0.0 1116.1990134278044 2312.509496254261 1296.7501944866933 1168.3633769707963 0.4023466131486532 0.0 0.0 0.5499530346764605 0.5672514125623696 0.0 0.9553526201084479 1.9792724950433493 1.1098860337857939 1.0 10.190273326535884 -7.470058064903762 4.796746750612123 1.4236312298190346 0.2650976734698522 0.7178402673033599 0.3160219181460976 0.1033966158473758 5.1242462912496345 0.13906965393305817 0.08876616097047915 3.3879885591336394e-08 7.470058064903762 -1.1585335563491823 HTNPSSS(ph)SPGTR ddPTM_A459_Selumetinib_30min_R2 1 HTNPSSSSPGTR 12 0 Q8WUH2 Q8WUH2 TGFBRAP1 Transforming growth factor-beta receptor-associated protein 1 1 HTNPSS(0.013)S(0.739)S(0.235)PGT(0.013)R 95.195 0.012079 2602800.0 719.05 0.0 523.55 459.71 441.56 1054.4 931.52 2484.8 1185.9 1226.8 True False 679.0880795852139 0.0 489.8653629981397 397.096704956017 386.0872852035147 1199.6340291097863 974.8375257718629 2492.0303566192174 1423.1131368145193 1191.379096390802 0.5700016742298591 0.0 0.41117505291317585 0.3333084373890671 0.3240675334770759 1.0069288883311718 0.8182429326862152 2.0917190541353676 1.1945090703083 1.0 10.21841683594879 -7.074256509034503 1.4942956629508939 1.4358387788665679 0.2981608358602059 0.6409712764349088 0.33839506137177056 0.2274793038437275 1.0173445616055314 0.1698897979021884 0.11835966964133166 8.428368027539731e-08 7.074256509034503 -1.137677943006362 HTNPSSSS(ph)PGTRT ddPTM_A459_Selumetinib_30min_R2 4 HTNPSSSSPGTRT 13 1 Q8WUH2 Q8WUH2 TGFBRAP1 Transforming growth factor-beta receptor-associated protein 1 1 HTNPS(0.082)S(0.044)S(0.175)S(0.698)PGTRT;HTNPSSS(0.029)S(0.595)PGT(0.196)RT(0.179);HTNPSS(0.001)S(0.016)S(0.945)PGT(0.016)RT(0.022);HTNPSS(0.012)S(0.054)S(0.615)PGT(0.16)RT(0.16) 117.2 0.0020412 6535260.0 10748.34 7614.980000000001 8401.789999999999 11013.85 13379.86 7358.459999999999 8429.9 12149.72 7661.39 14586.66 True False 10150.990291814109 8199.02447998007 7861.227978577285 9513.744630049006 11698.962369333956 8372.021071550831 8821.907053529956 12185.07367370557 9193.882077122344 14165.505225105853 0.7165992409379986 0.578802121751983 0.554955707802405 0.6716135061097275 0.8258768171995458 0.5910146470958836 0.6227739084021293 0.8601933697436842 0.6490331217292422 1.0 13.790094437160725 -14.52287874528031 0.16961377794199872 2.294824663213157 0.5956439450653629 0.5353829535891096 0.0935228063106822 103.42744406607753 0.9715065973762042 44.83724111447437 0.3432195676919026 3.0000000000001852e-15 14.52287874528031 -1.6991807181477943 HTNYTMEHIR ddPTM_A459_Selumetinib_30min_R1 11 HTNYTMEHIR 10 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;H7C5W8;F6THM6;H0YJ11;A0A494C060;H0YJW3 O43707;P12814-4 ACTN4;ACTN1;ACTN2 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2 0 ;;;;;;;;;; 204.56 3.2005e-05 106444100.0 13591.119999999999 16019.799999999997 17421.21 17510.100000000002 16419.04 14214.070000000002 14160.900000000001 13515.409999999998 8977.84 11406.04 False True 13907.766652284103 14144.19436859702 15055.505369856677 14452.28974028536 14933.940731016948 14071.089361142964 13092.731911994011 13156.93742256115 15234.738764510017 12870.116338238051 1.0806247812199736 1.0989950670899213 1.1698033626258433 1.1229338850144313 1.160357866124887 1.0933148536767097 1.0172970910212018 1.0222858190854835 1.1837296854299988 1.0 13.651737474276713 -7.001214475646222 21.553056478245168 1.05734537959996 1.1271775394533576 0.2840220669438326 0.0529073133464935 10.417613939121216 184901.4777510893 0.01869466588505802 0.01620262657579625 9.972074728592602e-08 7.001214475646222 0.06983215985339775 HTNYTMEHIR ddPTM_A459_Selumetinib_30min_R2 9 HTNYTMEHIR 10 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;H7C5W8;F6THM6;H0YJ11;A0A494C060;H0YJW3 O43707;P12814-4 ACTN4;ACTN1;ACTN2 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2 0 ;;;;;;;; 166.66 0.00018025 60696000.0 31703.82 22802.07 25251.65 31869.94 32459.800000000003 25059.63 23852.94 22628.34 15680.23 26155.69 False True 29941.848604847084 24550.91544878899 23626.986330917724 27529.199193287015 28381.909729706167 28511.366563828222 24962.148973703945 22694.18472307664 18816.714142232184 25400.50726905603 1.178789395333199 0.9665521711331313 0.93017773545417 1.0838050949802978 1.1173757054955438 1.1224723294625683 0.9827421440560712 0.8934539961224969 0.7408007227145222 1.0 14.632569688643104 -7.66486424150982 3.0189169157649607 0.85818949517925 1.058514138643263 0.4584382141575367 0.0908981095018666 0.2314346068806614 4.202475047255543 0.05191616599039633 0.026169313772351877 2.163394685429867e-08 7.66486424150982 0.20032464346401302 HTPLYER ddPTM_A459_Selumetinib_30min_R2 2 HTPLYER 7 0 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DH52;Q9NZB2-2;Q9NZB2-5;Q5T035 Q9NZB2-4 FAM120A;C9orf129 Constitutive coactivator of PPAR-gamma-like protein 1;Putative uncharacterized protein C9orf129 0 ; 130.04 0.0062264 1935540.0 8773.0 8429.4 8166.0 8831.3 10300.5 8174.4 8347.9 8959.7 6178.5 9213.8 False True 8285.431781101563 9075.907875207027 7640.608450468544 7628.461705157761 9006.459102361636 9300.349400184967 8736.093891050032 8985.771243641817 7414.372641713893 8947.773653672615 0.9259769079765229 1.0143202350097245 0.8539116819671064 0.852554166032872 1.0065586648657494 1.0394037399870566 0.9763427450429862 1.0042465971357697 0.8286276484732783 1.0 13.12731304655149 -6.282785143546561 24.843220390196418 0.9792765628959268 0.914894337360988 0.17607382320950715 0.06762379385590817 1399.9422860002799 1629315.204326206 0.021769203499538436 0.024706707427936774 5.214526230901258e-07 6.282785143546561 -0.06438222553493878 HTPPT(ph)IGGSLPYR ddPTM_A459_Selumetinib_30min_R1 1 HTPPTIGGSLPYR 13 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;E9PEZ7;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 HTPPT(0.953)IGGS(0.047)LPYR 98.368 0.029497 12919000.0 1425.4 1780.5 1897.3 2080.2 1612.6 1429.4 1656.3 1771.3 1224.6 1162.8 True False 1458.6090466544154 1572.0382322680057 1639.6570811229 1716.9321201901535 1466.7406147276547 1415.0215337913592 1531.3639575052196 1724.3193700067213 2078.056758754775 1312.0567066311537 1.111696650977495 1.1981480863768323 1.2496846156389807 1.3085807278852761 1.1178942246281935 1.0784758971466857 1.1671476924478064 1.314211010310748 1.5838162697177993 1.0 10.357614358739744 -7.805587818676818 5.8472368401460635 1.3401028409051507 1.178675248933033 0.11214729441236815 0.14698219914260835 0.32024975785717685 25.925228981276437 0.07823997926121314 0.03771114864777048 1.56463190305493e-08 7.805587818676818 -0.16142759197211776 HTPPTIGGS(ph)LPYR ddPTM_A459_Selumetinib_30min_R1 2 HTPPTIGGSLPYR 13 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;E9PEZ7;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 HTPPT(0.023)IGGS(0.976)LPY(0.001)R;HTPPT(0.137)IGGS(0.863)LPYR 97.904 0.0085929 32146000.0 5006.3 6072.3 5993.0 6035.299999999999 4928.4 5123.4 4821.9 4789.0 2959.36 3861.98 True False 5122.937049435947 5361.352293064317 5179.183517192607 4981.3481516121665 4482.627090179689 5071.863247675002 4458.18020086604 4661.980163135657 5021.817776897381 4357.702751870816 1.1756049783883507 1.2303162006088233 1.1885123451729511 1.1431133409624168 1.0286674758289194 1.163884628316511 1.0230574352397228 1.0698251873958613 1.1524002583107469 1.0 12.08935207518944 -5.951936555304921 3.056527180316938 1.0784001885006924 1.201964105884707 0.543735955842923 0.05146989670707213 0.1912112285583784 3.6520300853565155 0.014727259140370489 0.02253448104541837 1.1170264186869193e-06 5.951936555304921 0.12356391738401462 HTPPTIGGS(ph)LPYR ddPTM_A459_Selumetinib_30min_R2 4 HTPPTIGGSLPYR 13 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;E9PEZ7;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 HTPPT(0.416)IGGS(0.584)LPYR;HTPPT(0.008)IGGS(0.992)LPYR;HT(0.009)PPT(0.11)IGGS(0.881)LPYR;HTPPT(0.011)IGGS(0.989)LPYR 98.552 0.0082443 55962700.0 151518.0 144271.0 164996.0 175014.0 169421.0 124645.0 125592.0 129202.0 117089.0 135467.0 True False 143097.23613461136 155336.12179561905 154380.3369940616 151176.79128401 148136.81933704307 141813.7173353464 131432.27685582667 129577.95642945745 140510.0717400077 131555.71572446454 1.087731044953758 1.180763001745672 1.1734977544981917 1.149146507633622 1.126038640900306 1.0779745794729787 0.9990616989314519 0.9849663750136909 1.068065123329932 1.0 17.005314405329088 -6.91661664968878 2.1059399565323553 1.0116642650352263 1.1505802045924294 0.7906572558371259 0.031620379996452945 0.13671686549019962 1.2336883656115227 0.01325555330067056 0.010977598038331121 1.2116671963022057e-07 6.91661664968878 0.13891593955720305 HTPS(ph)PGLPAEGAPEAPRPS(ph)SPPPEVLEPHSLDQPPATSPR ddPTM_A459_Selumetinib_30min_R2 2 HTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPR 40 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 2 HT(0.223)PS(0.715)PGLPAEGAPEAPRPS(0.53)S(0.53)PPPEVLEPHS(0.001)LDQPPATSPR;HT(0.251)PS(0.748)PGLPAEGAPEAPRPS(0.499)S(0.499)PPPEVLEPHS(0.002)LDQPPATSPR 62.709 1.2828e-05 11624300.0 16331.0 13926.3 12426.5 14026.3 19090.2 12116.3 13560.5 14849.3 11717.3 14401.3 True False 15423.38839817277 14994.402429887723 11626.992518950203 12115.893743282903 16691.918407446643 13785.210344179539 14191.09011962099 14892.509004566056 14061.087408716401 13985.497049928956 1.1028130314647 1.0721394010064085 0.8313606929693833 0.8663184225793712 1.1935162796041943 0.9856789712203733 1.0147004478252046 1.0648537518115389 1.0054049104238185 1.0 13.771643908209787 -6.233674169428344 24.994560656063268 1.0428848805604498 0.9658139407082241 0.1347206800247882 0.09409256133030917 1664.771216470958 1498646.77063803 0.02943687779711257 0.03799468792272279 5.838829997357498e-07 6.233674169428344 -0.07707093985222568 HTPSPGLPAEGAPEAPRPS(ph)SPPPEVLEPHSLDQPPATSPR ddPTM_A459_Selumetinib_30min_R1 2 HTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPR 40 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 HTPSPGLPAEGAPEAPRPS(0.493)S(0.493)PPPEVLEPHS(0.012)LDQPPAT(0.001)SPR;HTPSPGLPAEGAPEAPRPS(0.5)S(0.5)PPPEVLEPHSLDQPPATSPR 78.22800000000002 4.5511e-09 23855000.0 2206.1800000000003 2904.77 1747.67 2438.13 2630.57 2020.51 2562.04 2508.7400000000002 1228.03 2136.71 True False 2257.5797015210032 2564.6781780090637 1510.3460132641424 2012.3563648683867 2392.6354079648536 2000.185503876297 2368.783260089761 2442.2000656640116 2083.877218237486 2410.9775418179 0.9363752512679013 1.0637503392401042 0.6264454923646144 0.834664085402907 0.9923922419288832 0.829615983219876 0.9824990979815083 1.0129501512579704 0.8643287554915268 1.0 11.235402497004912 -7.27675208200262 23.985012441867443 0.9660236898731537 0.8803173775824651 0.11431774257209548 0.11507670795250496 1191.0636229805407 1865608.9512088492 0.04974483023219011 0.03369493640152226 5.287470020739107e-08 7.27675208200262 -0.08570631229068859 HTPSPGLPAEGAPEAPRPS(ph)SPPPEVLEPHSLDQPPATSPR ddPTM_A459_Selumetinib_30min_R2 3 HTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPR 40 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 HTPSPGLPAEGAPEAPRPS(0.499)S(0.499)PPPEVLEPHS(0.002)LDQPPATSPR;HT(0.001)PS(0.002)PGLPAEGAPEAPRPS(0.498)S(0.498)PPPEVLEPHS(0.001)LDQPPATSPR;HT(0.002)PS(0.003)PGLPAEGAPEAPRPS(0.496)S(0.496)PPPEVLEPHS(0.002)LDQPPATSPR 73.077 2.107e-08 26215500.0 28877.5 22974.7 35184.0 44187.0 40059.3 32025.4 29029.4 28146.3 25472.2 26055.1 True False 27272.604155791676 24736.785614696066 32920.29974544275 38168.654373173355 35026.69259931415 36436.60815236393 30379.32462066484 28228.201073129192 30567.351752733615 25302.82156372023 1.0778483374714134 0.9776295324377673 1.3010525194804614 1.508474233873603 1.3842998699218678 1.440021543075954 1.2006299196380303 1.1156147547435358 1.2080609933463622 1.0 14.627010650991373 -8.36252859915371 1.0836014934233928 1.0199550652415688 1.2773001248726497 0.20128657708173736 0.15580705997259603 0.8867465495054974 2.217322297700819 0.16845791430504564 0.055600247882914955 4.339816841483881e-09 8.36252859915371 0.2573450596310809 HTQLEQMFR ddPTM_A459_Selumetinib_30min_R1 1 HTQLEQMFR 9 0 A0A087X020;Q9Y3A5 A0A087X020 SBDS Ribosome maturation protein SBDS 0 149.72 0.027939 13128000.0 1172.2 1365.5 1377.8 1512.5 1305.3 1184.5 1123.6 1092.7 564.02 954.84 False True 1199.50997929585 1205.626625196272 1190.7023277136623 1248.3702681413363 1187.2358454694324 1172.5850054399496 1038.84594738445 1063.7180464101764 957.1007456090709 1077.403014929215 1.1133345300455255 1.1190117425794295 1.1051596396283436 1.1586845877012455 1.1019421971335706 1.0883439058475142 0.9642129574444358 0.9872981898793575 0.888340511718312 1.0 10.073342292094244 -7.2061601781795614 2.1941571838376914 0.9525239472802932 1.1215185638344012 0.8556623673261884 0.031248673722518924 0.10727175011259459 1.010922522550387 0.014130356029132778 0.009570629571021666 6.220708082790613e-08 7.2061601781795614 0.16899461655410797 HTS(ph)ALCNSCR ddPTM_A459_Selumetinib_30min_R2 1 HTSALCNSCR 10 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 HT(0.188)S(0.812)ALCNSCR 73.881 0.042285 3427100.0 7056.2 8655.8 6464.4 7505.1 9683.4 5630.1 5885.2 9240.3 5018.4 9112.4 True False 6664.044652206642 9319.672027216295 6048.487541906553 6482.892432980362 8466.88472130563 6405.595170040787 6158.873461302565 9267.18774318598 6022.2202258116085 8849.30133514146 0.7530588460970422 1.0531534269498708 0.6834988789326684 0.7325880527128338 0.9567856716193838 0.7238532091345481 0.6959728489349847 1.0472225311601777 0.6805305862844528 1.0 13.11134784153958 -10.764829519696965 3.52104098617614 1.0003668260373786 0.8197960818193836 0.13379514728421282 0.1412489722615515 131085438.55493398 191816082.54562593 539329.1354599413 0.03373836473950389 1.7185828765753757e-11 10.764829519696965 -0.18057074421799502 HTTFEQPVFSVS(ph)KQSPPISTSK ddPTM_A459_Selumetinib_30min_R1 1 HTTFEQPVFSVSKQSPPISTSK 22 1 P33981-2;P33981 P33981-2 TTK Dual specificity protein kinase TTK 1 HTTFEQPVFS(0.033)VS(0.483)KQS(0.483)PPIS(0.001)TSK 73.44800000000002 0.0010192 15235000.0 2053.0 2270.8 2613.2 3339.7 4292.1 2212.6 3331.9 2114.0 763.23 1575.0 True False 2100.8309055573977 2004.933680333721 2258.341793280115 2756.4840889333004 3903.8803128318023 2190.3432528800618 3080.57210047192 2057.9298527602377 1295.1455658863354 1777.1665917991636 1.1821237892113219 1.1281630487460217 1.2707541339688477 1.5510555406866486 2.1966878799356686 1.232491800705418 1.7334177418635908 1.157983647822704 0.7287699261638488 1.0 10.79536321076551 -7.9929164386703135 5.805431063756256 0.8840667102608616 1.4715466581038372 0.3895741320329197 0.30629898628387847 0.16748523529743545 20.888693893791743 0.19726066746470436 0.0856731197389871 1.0164442451184174e-08 7.9929164386703135 0.5874799478429756 HTTSVS(ph)PSPAGR ddPTM_A459_Selumetinib_30min_R1 2 HTTSVSPSPAGR 12 0 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;Q8N1I0-4 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 HTTS(0.001)VS(0.987)PS(0.012)PAGR;HTTS(0.001)VS(0.999)PSPAGR 111.66 0.0044346 2870200.0 1044.67 1082.27 1033.94 1421.8600000000001 1647.95 1272.94 1558.65 1185.1399999999999 247.54000000000002 569.44 True False 1069.008778426033 955.557325266327 893.5366270258843 1173.5588426178115 1498.893213469204 1260.1353793370445 1441.0797756236857 1153.7062373227393 420.0573003937262 642.5331708153112 1.6637409973240234 1.4871719759679005 1.390646689714205 1.826456432013745 2.332787288736014 1.9611989490566797 2.2428099296338235 1.7955590306081783 0.6537519298197709 1.0 9.327627125225929 -8.253065979416563 23.024545115270353 0.826875936123802 1.8447396249272845 0.6605302501507881 0.2897802133349799 123.80503812260861 340436.8716367213 0.23070841871961034 0.08355109547054292 5.583853565906064e-09 8.253065979416563 1.0178636888034824 HTTSVS(ph)PSPAGR ddPTM_A459_Selumetinib_30min_R2 3 HTTSVSPSPAGR 12 0 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;Q8N1I0-4 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 HTTSVS(0.998)PS(0.002)PAGR;HTTS(0.001)VS(0.998)PS(0.001)PAGR;HTTS(0.01)VS(0.986)PS(0.004)PAGR 112.02 0.0043342 3863280.0 10842.0 11119.099999999999 16172.2 20414.5 23631.7 16383.1 15063.800000000001 17487.9 15917.8 21137.6 True False 10239.445043964795 11971.899216458394 15131.698258960014 17634.009883023235 20662.874575921498 18639.72331402554 15764.296548353419 17538.7868937223 19101.8047804926 20527.302565919643 0.49882077837956096 0.5832183346064516 0.7371498622562491 0.8590514913683797 1.0066044727292585 0.9080454314037371 0.7679672717703308 0.8544126456654362 0.9305560104232243 1.0 14.325256439024702 -5.398798181968243 1.7160782532959586 0.899035075188613 0.5039968446039204 0.8312021825516798 0.06604405421815165 0.17436610133141564 0.938967964284479 0.02106828968129018 0.07461218735684448 3.992103735989261e-06 5.398798181968243 -0.3950382305846927 HTVDDGLDIR ddPTM_A459_Selumetinib_30min_R2 1 HTVDDGLDIR 10 0 Q86VP6-2;Q86VP6;A0A0C4DGH5 Q86VP6-2 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 150.04 0.0010189 4172200.0 15145.0 10746.0 15091.0 13545.0 19371.0 11564.0 12349.0 14015.0 11876.0 14104.0 False True 14303.30153023859 11570.183646163992 14120.061489838467 11700.147633571716 16937.4418010628 13156.83603245976 12923.25296907927 14055.78132969185 14251.531843164892 13696.78087340713 1.0442819858503427 0.8447374425495837 1.0309036568770078 0.8542260945627042 1.2366001878549104 0.960578704884175 0.9435248390496124 1.0262105716374375 1.0405022884490205 1.0 13.741549238889315 HTVLYIS(ph)PPPEDLLDNSR ddPTM_A459_Selumetinib_30min_R1 4 HTVLYISPPPEDLLDNSR 18 0 O94916;O94916-4;O94916-5;O94916-2 O94916 NFAT5 Nuclear factor of activated T-cells 5 1 HTVLY(0.007)IS(0.993)PPPEDLLDNSR;HT(0.001)VLYIS(0.999)PPPEDLLDNSR;HTVLY(0.001)IS(0.998)PPPEDLLDNSR;HT(0.003)VLY(0.003)IS(0.994)PPPEDLLDNSR 107.57 0.0010454 19199100.0 6788.81 6987.409999999999 6971.54 7207.849999999999 7268.83 6218.33 6993.18 6945.67 3498.52 5941.6 True False 6946.976064275259 6169.320788841218 6024.843159928076 5949.134305601672 6611.365609916166 6155.779245991896 6465.67880235848 6761.448268884201 5936.73291820901 6704.262236085019 1.036202913854392 0.9202087525209661 0.8986586365163286 0.8873659913809835 0.9861436466985366 0.9181889116536986 0.9644131710059927 1.0085298025025609 0.8855162147827602 1.0 12.710862865575875 -7.34699035830761 10.090520593865927 0.9654044143419821 0.937858234981992 0.045756495056749835 0.05121232895730603 1.7182729815136712 194.55328753839228 0.021299560587777735 0.01434577335906315 4.49789840484456e-08 7.34699035830761 -0.027546179359990153 HTVLYIS(ph)PPPEDLLDNSR ddPTM_A459_Selumetinib_30min_R2 2 HTVLYISPPPEDLLDNSR 18 0 O94916;O94916-4;O94916-5;O94916-2 O94916 NFAT5 Nuclear factor of activated T-cells 5 1 HTVLY(0.002)IS(0.998)PPPEDLLDNSR;HT(0.001)VLY(0.001)IS(0.999)PPPEDLLDNSR 106.42 0.0010994000000000002 6402600.0 20097.6 20517.6 24116.9 24194.0 30257.0 21701.2 24111.0 26599.0 20170.3 24697.0 True False 18980.65584906722 22091.23394551779 22565.244910495352 20898.73546302208 26455.845158988002 24690.343316120357 25232.209275040117 26676.39868629852 24204.92360527017 23983.933439487788 0.7913904488167468 0.9210846920191245 0.9408483794965563 0.8713639702073991 1.1030653176943193 1.0294534621860447 1.0520463350476588 1.1122612040933113 1.0092140918561148 1.0 14.549780664168084 -6.255011717611913 24.954510805061684 1.0555941127783246 0.8882853874586405 0.7344064769125567 0.049915967719802244 261.7664326612507 1016271.5228549646 0.014585972649920174 0.018364581400804526 5.558892587319814e-07 6.255011717611913 -0.1673087253196841 HVAT(ph)VQNEEEAQKGK ddPTM_A459_Selumetinib_30min_R1 1 HVATVQNEEEAQKGK 15 1 A0A3B3ITU3;Q9H246 A0A3B3ITU3 C1orf21 Uncharacterized protein C1orf21 1 HVAT(1)VQNEEEAQKGK 65.71600000000001 0.02288 856000.0 453.1 311.89 197.66 258.79 566.76 263.8 382.96 291.1 0.0 152.57 True False 463.65634842087485 275.37377380627254 170.8188576686619 213.59718458994791 515.4966580696051 261.1464115112358 354.0730188771351 283.3790823739383 0.0 172.15384565764973 2.693267447204843 1.599579566487809 0.9922453780577019 1.2407343197822815 2.994395252109193 1.516936264267714 2.0567244229981085 1.6460804653616299 0.0 1.0 7.427554598677044 -8.157009284155183 5.839364320164075 0.5145213338655205 1.8312996085984765 0.42912213416847933 0.6216266402146455 0.21345035520128888 9.714014495654304 0.440696703513403 0.16122009174562937 6.966116220967064e-09 8.157009284155183 1.3167782747329562 HVDSLSQR ddPTM_A459_Selumetinib_30min_R2 3 HVDSLSQR 8 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 0 ;; 136.27 0.0036604 995340.0 5337.539999999999 4768.17 3557.3599999999997 6594.3099999999995 6776.5 4049.33 7121.9 10322.4 7651.4 11186.900000000001 False True 5040.900894665549 5133.87330691697 3328.4833305607135 5696.153602180752 5925.1754873213595 4607.088451342118 7453.082461777121 10352.43647503469 9181.893797978422 10863.90512994316 0.4640045024667776 0.4725624207419631 0.3063800070737665 0.5243191590914191 0.5454001499875358 0.4240729642091621 0.6860408271823814 0.9529203680637125 0.8451743353935623 1.0 13.407255165831796 -7.527453099091404 2.6441519421453408 0.9282507590303061 0.4564954611810581 0.897411213350739 0.07217619306590127 0.08512147952700429 1.1962055633776396 0.03959166779555546 0.021659756238184023 2.96856731163148e-08 7.527453099091404 -0.47175529784924797 HVEEFSPR ddPTM_A459_Selumetinib_30min_R1 2 HVEEFSPR 8 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 ; 157.68 0.00074678 10222100.0 2290.81 2470.02 2691.67 3311.28 2921.96 2616.48 2693.31 2479.7200000000003 1430.29 2075.94 False True 2344.18141585969 2180.828910118856 2326.15599828497 2733.027108423831 2657.669233913938 2590.1605867737608 2490.151458303679 2413.949770334258 2427.0976657515653 2342.4071203679723 1.0007574667427748 0.9310204409625712 0.993062212823 1.166760075419552 1.1345889494634225 1.1057687471368634 1.063073723030904 1.0305423635986246 1.0361553483368378 1.0 11.193776128857724 -5.565434209583424 11.633125290098315 1.080987905535093 0.9649210028729278 0.47213787413537656 0.049711542521338734 0.5762964087943043 156.00477165686198 0.014345902787967484 0.02487177622509482 2.7199804993847993e-06 5.565434209583424 -0.11606690266216524 HVEEFSPR ddPTM_A459_Selumetinib_30min_R2 2 HVEEFSPR 8 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 ; 121.05 0.0099558 7309900.0 10461.0 13690.2 17295.0 16593.6 18790.7 10093.5 11472.2 12042.5 10749.7 13932.4 False True 9879.61949870095 14740.19431906889 16182.258529372224 14333.523054443373 16430.044275010616 11483.788005329698 12005.680031733044 12077.541681256798 12899.940371713506 13530.135411277475 0.7301936897443175 1.089434353094709 1.1960160070448507 1.05937764987158 1.214329626096428 0.8487563247709901 0.887328889681785 0.8926401188261628 0.9534228579088206 1.0 13.7238886576075 -6.782950985955126 24.999973675810807 0.9079008360047464 1.0673823953981385 0.22745749102727209 0.12926540383581234 340.21907804120724 395387.07169246516 0.046071487274370236 0.04066823161239398 1.6483484119966548e-07 6.782950985955126 0.15948155939339215 HVEVSQAPLPPAPAYLS(ph)SPLALPSQR ddPTM_A459_Selumetinib_30min_R2 1 HVEVSQAPLPPAPAYLSSPLALPSQR 26 0 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9-3;Q9Y6K9;Q9Y6K9-2 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 HVEVSQAPLPPAPAYLS(0.496)S(0.496)PLALPS(0.007)QR 133.31 3.4181e-09 10588000.0 12668.0 10491.0 10680.0 11734.0 15888.0 8935.1 11336.0 9186.6 9491.4 10758.0 True False 11963.963274021957 11295.625966118218 9992.860427504787 10135.808957720963 13892.007399477856 10165.828920237913 11863.146461857854 9213.331485076505 11389.945211873966 10447.388587359184 1.1451630399292079 1.0811913304139331 0.9564936102401367 0.9701763146806641 1.3297109879005062 0.9730497564279418 1.1355130866111045 0.881878893279051 1.0902193516239291 1.0 13.350854753158664 -7.738569046907603 24.999958668909837 0.9895366707440717 1.0801736965931463 0.1233689853514035 0.11413343567377587 502.5732433681847 549372.4491483173 0.053386509337704946 0.030796632836437878 1.825706463537975e-08 7.738569046907603 0.09063702584907463 HVFGESDELIGQK ddPTM_A459_Selumetinib_30min_R1 2 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 ; 139.32 0.0013219000000000002 33216000.0 7053.5 8576.7 8223.6 8325.7 8912.3 7632.099999999999 8826.8 7595.5 3991.8 5969.0 False True 7217.832826278177 7572.535976800348 7106.8802890013585 6871.7727877450025 8106.184038594367 7555.328003392348 8160.9873695025535 7394.042666338882 6773.79305046326 6735.179292983624 1.0716615716225042 1.1243258193124928 1.0551879882997257 1.0202806026119713 1.2035587600524589 1.1217708801402086 1.211695637858411 1.0978241773075927 1.0057331447018585 1.0 12.717500635940672 -8.235865479711284 4.584255138778545 1.0003986124403976 1.1159022518625012 0.3821547654398102 0.05643555286857238 0.20841170646542737 11.068060885763284 0.04777491868792665 0.015323276571360182 5.809443339166488e-09 8.235865479711284 0.11550363942210362 HVFGESDELIGQK ddPTM_A459_Selumetinib_30min_R2 2 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 ; 174.42 0.00017415 31171000.0 385010.0 334690.0 419570.0 471580.0 493870.0 358720.0 356630.0 380530.0 331170.0 437810.0 False True 363612.68551714486 360359.6468020307 392575.3229932758 407349.99047912576 431825.635346181 408130.4238640578 373214.0016489388 381637.2792998677 397413.25366292725 425169.2877330096 0.8552186058779485 0.8475674447781916 0.923338854239628 0.9580889359415027 1.0156557583184402 0.9599245186316195 0.8778009428642062 0.8976125282584418 0.9347176880576753 1.0 18.697677861438564 -5.347187782848958 3.6107844972689613 0.9448605062071407 0.8502788934084736 0.48783652683462575 0.03923637346276454 0.2221340774626021 5.429717999157107 0.011760332906196335 0.028022447034576976 4.495854184248504e-06 5.347187782848958 -0.09458161279866706 HVIADQEVMETNRVES(ph)VEPSENEASK ddPTM_A459_Selumetinib_30min_R2 2 HVIADQEVMETNRVESVEPSENEASK 26 1 Q9H307 Q9H307 PNN Pinin 1 HVIADQEVMETNRVES(0.982)VEPS(0.018)ENEASK;HVIADQEVMET(0.002)NRVES(0.94)VEPS(0.058)ENEAS(0.001)K 85.01299999999998 4.0053e-05 8279200.0 27649.0 21191.3 28004.0 29293.0 25744.0 25079.0 25847.0 24889.8 23947.0 27653.0 True False 26112.379267716533 22816.604569230858 26202.253128449825 25303.242866756464 22509.80856571991 28533.404605504853 27048.936714858854 24962.225197271808 28737.069135084992 26854.58603887742 0.9723620103439169 0.8496353113095555 0.9757086961056405 0.9422317227353617 0.8382109682544513 1.062515153434017 1.0072371503213668 0.9295330473958512 1.0700991291946298 1.0 14.712880862194947 -6.771137795818851 24.999999322154768 1.0090577201475786 0.9167789862673252 0.437368786067312 0.05557386119830437 206.901492456604 533335.1416777709 0.01900252606035346 0.01696532393896732 1.6938002950462848e-07 6.771137795818851 -0.09227873388025332 HVINFDLPSDIEEYVHR ddPTM_A459_Selumetinib_30min_R1 2 HVINFDLPSDIEEYVHR 17 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;O15523;O15523-2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 ; 192.78 4.7297e-08 26057000.0 9107.2 10766.5 9890.6 10232.900000000001 8836.2 8902.6 8374.1 8015.9 5237.2 6592.7 False True 9319.380040473616 9505.953174789947 8547.510845176905 8445.916110322962 8036.967270157819 8813.04792691405 7742.434894973415 7803.292292687229 8887.145890046146 7438.937263336092 1.2527837929761239 1.2778644096975318 1.1490231121190635 1.1353659550202035 1.0803918605106684 1.1847186788831339 1.040798520123722 1.0489794464522393 1.19467950534383 1.0 12.860880815346544 -1.5228787452837138 0.2826506176477765 1.0575777191841724 2.8344387796797124 0.561832824661904 0.05845093995545408 37.88101766348241 0.5350226128444008 0.06294307481605235 33.347617442035165 0.029999999999766776 1.5228787452837138 1.77686106049554 HVLTGSADNSCR ddPTM_A459_Selumetinib_30min_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 159.44 0.00065118 2532500.0 1128.8 1254.9 1363.0 1289.5 1342.6 961.09 1331.6 1364.6 706.67 1092.7 False True 1155.098843737549 1107.9757246128172 1177.912086423082 1064.313031912894 1221.1620670552827 951.4223071999002 1231.1563399226898 1328.406375154505 1199.1673768652925 1232.9586887993307 0.9368512134517641 0.8986316692344142 0.9553540577828655 0.8632187287226422 0.9904322652078995 0.7716578956318529 0.9985381919986337 1.077413531549968 0.9725933137573777 1.0 10.26790874663902 -7.499145869624967 24.79642479602124 1.022597248012239 0.9052612548410267 0.44187870750392777 0.06036435404928046 570.8757093239116 596460.5356986298 0.02366149396987319 0.015841590463587966 3.168503056287819e-08 7.499145869624967 -0.11733599317121224 HVLTGSADNSCR ddPTM_A459_Selumetinib_30min_R2 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 112.84 0.0087198 2411600.0 3248.7 3961.6 3247.1 3895.6 4856.6 2563.7 2945.7 4372.7 1907.6 3067.8 False True 3068.150259576502 4265.441981448283 3038.185121175167 3365.0125597151673 4246.470489445126 2916.826404048518 3082.6808867938153 4385.423833060543 2289.173302797351 2979.224642898353 1.0298485771759853 1.4317288867813025 1.0197905446362896 1.1294927248055717 1.42536095744493 0.9790555442005437 1.034725895592356 1.4720017315626668 0.7683788828258072 1.0 11.54072119608987 -8.28359756501772 24.968649837288478 0.8841894238729149 1.1862056608924858 0.3013358519103049 0.18633189195663033 1108.0643947036365 1248594.981048876 0.17033462992457346 0.04411867933055614 5.204780693547865e-09 8.28359756501772 0.3020162370195709 HVS(ph)PVTPPR ddPTM_A459_Selumetinib_30min_R1 4 HVSPVTPPR 9 0 Q13443 Q13443 ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 1 HVS(1)PVTPPR;HVS(0.999)PVT(0.001)PPR;HVS(1)PVTPPR;HVS(0.99)PVT(0.01)PPR 103.43 0.010084 38463200.0 9581.58 9773.92 12645.900000000001 9632.55 12592.8 10253.64 10796.48 11884.04 5770.85 9191.7 True False 9804.812171490817 8629.58490262787 10928.656238956455 7950.405967857733 11453.783463439408 10150.497691160224 9982.092821304088 11568.83665439773 9792.710963792253 10371.54422973992 0.9453570224746258 0.8320443621001912 1.0537154349319595 0.7665595201397603 1.104346971842073 0.9786872105365124 0.9624500074618494 1.1154401310100601 0.9441902523745799 1.0 13.340343094021314 -6.279249449668583 24.998817336523057 1.018596046329454 0.905627752725421 0.30580683500700867 0.08696091658532608 1028.3089914100544 1443365.6184077568 0.025286798915152557 0.028730066916230895 5.25715219825709e-07 6.279249449668583 -0.11296829360403315 HVS(ph)PVTPPR ddPTM_A459_Selumetinib_30min_R2 3 HVSPVTPPR 9 0 Q13443 Q13443 ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 1 HVS(0.999)PVT(0.001)PPR;HVS(0.999)PVT(0.001)PPR;HVS(0.999)PVT(0.001)PPR 95.618 0.014695 32751600.0 64330.0 26722.0 50551.0 61010.0 48453.0 37036.3 67835.0 58815.0 52735.0 47902.0 True False 60754.79613339377 28771.491475227453 47298.60369576727 52700.3327518797 42365.90096468411 42137.71414294268 70989.4619125025 58986.141912652616 63283.47353901146 46518.94479565714 1.306022662385619 0.6184897701702268 1.016760029780016 1.1328789374603276 0.9107236019816007 0.905818356973491 1.5260333660691687 1.2680025776973207 1.3603806753785053 1.0 15.505530751611262 -7.244882779954327 24.89263115937442 1.3109377122578385 0.9704969141272225 0.346997268710204 0.2049359425811325 768.7091966675141 1155745.819970774 0.07481301124776538 0.057778089897857814 5.6900649016596954e-08 7.244882779954327 -0.340440798130616 HVTLGPGQS(ph)PLSR ddPTM_A459_Selumetinib_30min_R2 2 HVTLGPGQSPLSR 13 0 O15061 O15061 SYNM Synemin 1 HVTLGPGQS(0.925)PLS(0.074)R;HVTLGPGQS(0.998)PLS(0.002)R 130.66 0.0016026 11001300.0 27458.0 26495.0 34469.0 38832.0 41710.0 28695.0 28162.0 28402.0 28522.0 41352.0 True False 25931.994283082957 28527.08130514748 32251.302067009583 33543.01461106361 36470.016907868936 32647.47578272508 29471.588801944352 28484.64511779577 34227.196971265505 40158.06031460093 0.6457481780725957 0.7103699999866632 0.8031090599085395 0.835274770451695 0.908161814145414 0.8129744197544048 0.7338897489336376 0.7093132709758677 0.8523120066837729 1.0 15.293401966515237 -14.522878745280336 0.21801831491948584 2.0752220659454683 0.7535293458349996 0.46949767359139505 0.07293283600013828 161.713324502817 1.6129408593098806 76.53999623233298 0.16081815564663215 3.0000000000000132e-15 14.522878745280336 -1.3216927201104687 HVTLPS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 HVTLPSSPR 9 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 HVTLPS(0.693)S(0.307)PR 96.334 0.014272 85201000.0 2939.2 3484.6 3313.0 3117.4 4081.5 3139.7 3280.4 3194.5 984.6 2411.9 True False 3007.6776413123716 3076.621412053409 2863.11279700636 2573.004610845489 3712.329045647352 3108.117468619512 3032.956786934807 3109.7714828016015 1670.7942876612367 2721.490858895495 1.1051580906404457 1.1304911798608952 1.0520383662682378 0.9454393728479145 1.3640791897254376 1.1420642690973166 1.1144468029430454 1.142672029427168 0.6139261067881452 1.0 11.410181474923776 -8.239444644465571 24.466656178338752 0.8069630536002578 1.1245909285822666 0.4864196199564851 0.130532728615964 423.46576970106884 471059.61735678103 0.08568934220667875 0.03232320327959175 5.761762537823053e-09 8.239444644465571 0.31762787498200884 HVTLPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 4 HVTLPSSPR 9 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 HVTLPS(0.665)S(0.335)PR;HVTLPS(0.532)S(0.468)PR;HVTLPS(0.694)S(0.306)PR;HVTLPS(0.694)S(0.306)PR 124.12 0.0035781 256283900.0 222124.0 142308.0 274698.0 302847.0 351548.0 234361.0 230838.0 225626.0 229283.0 251377.0 True False 209779.23731282377 153222.5660076588 257024.22974856896 261598.71615978586 307383.3973610048 266642.1004326619 241572.42439681917 226282.53430560508 275146.0067022887 244119.0928541165 0.8593315453543245 0.6276549868191724 1.0528641031046453 1.0716028521215055 1.2591534474720276 1.0922623761837627 0.9895679259351534 0.9269350121697757 1.1270974485666863 1.0 17.897225608919875 -5.277943805691975 22.496453539577825 1.0677847646769192 0.7434933490553265 0.6268691963083036 0.09917895521061311 122.06000532918411 166375.21196303394 0.02710679335736795 0.056796384974804846 5.272980852555483e-06 5.277943805691975 -0.3242914156215927 HVTLPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 HVTLPSSPR 9 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 HVTLPS(0.289)S(0.711)PR;HVTLPS(0.212)S(0.788)PR;HVTLPS(0.226)S(0.774)PR 129.74 0.0026529 183312000.0 9115.6 11799.5 10641.3 11845.6 13246.5 10190.5 12133.5 11079.3 3355.7700000000004 7180.5 True False 9327.975744130057 10418.009054561271 9196.269908476836 9776.988329451247 12048.356413859527 10087.992822233697 11218.260326263107 10785.44097336164 5694.496594256498 8102.18711899295 1.1512910782156145 1.285826765237207 1.1350354877535676 1.2067097668643407 1.4870498838043449 1.2450950186753487 1.3845965492410728 1.3311764854305415 0.702834495257163 1.0 12.984095688931792 -8.253348316228335 24.999497460371366 0.8514172382342978 1.2808218961943298 0.6681587294448657 0.1203388690447101 308.1216098389853 952031.4139930486 0.08420797322384575 0.030599763931068846 5.580224657098581e-09 8.253348316228335 0.429404657960032 HVTLPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 HVTLPSSPR 9 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 HVTLPS(0.199)S(0.801)PR;HVTLPS(0.19)S(0.81)PR 116.03 0.0052788 164249000.0 147291.0 81555.0 173146.0 189880.0 267779.0 146149.0 134235.0 166471.0 166906.0 172246.0 True False 139105.1558725899 87810.00625934346 162005.9748671105 164018.01643872957 234138.20804536663 166279.69814147026 140477.19348160634 166955.40304924225 200291.8637432876 167272.8104311457 0.8316064966807596 0.5249508634010103 0.9685134986943786 0.9805420021100446 1.3997385913578861 0.9940629186111257 0.8398088913525535 0.9981024568124052 1.1973964162318746 1.0 17.351843434194322 -5.427221127141329 4.600970717108159 1.0559622777259698 0.6808159627000792 0.4728889851711756 0.15786929189982624 0.1918642295247782 6.73756745616259 0.04356023227055613 0.09372860961527804 3.7392015309179787e-06 5.427221127141329 -0.3751463150258907 HVTSNAS(ph)DSESSYR ddPTM_A459_Selumetinib_30min_R2 1 HVTSNASDSESSYR 14 0 A0A590UK48;Q12959;Q12959-3;Q12959-5;Q12959-8;A0A590UJ64;C9JUA9 A0A590UK48 DLG1 Disks large homolog 1 1 HVTSNAS(0.997)DS(0.003)ESSYR 164.63 0.00025915 4874900.0 5965.6 5598.6 10100.0 8505.0 14070.0 11291.0 8992.2 10371.0 11582.0 8985.5 True False 5634.055834188931 6027.99461766366 9450.176996048533 7346.604328056657 12302.400812604074 12846.23276050701 9410.355117706269 10401.17789298853 13898.723628118525 8726.065267867252 0.6456582275330559 0.6908032925058524 1.0829826165577445 0.8419148954924388 1.4098451518471071 1.4721678518509147 1.07841906160831 1.1919665477737933 1.5927824513643052 1.0 13.091115549263076 -5.582192043233354 1.0488113847304277 1.291558548851417 0.6027987917744737 0.5717219685526378 0.2003273601982021 0.4998520393652064 0.957074739105056 0.07347334344965381 0.2876017500242498 2.6170255144014527e-06 5.582192043233354 -0.6887597570769433 HVTSNASDS(ph)ESSYR ddPTM_A459_Selumetinib_30min_R1 1 HVTSNASDSESSYR 14 0 A0A590UK48;Q12959;Q12959-3;Q12959-5;Q12959-8;A0A590UJ64;C9JUA9 A0A590UK48 DLG1 Disks large homolog 1 1 HVTSNAS(0.22)DS(0.374)ES(0.173)S(0.233)YR 104.95 0.0059948 1957500.0 360.56 357.65 436.84 534.55 339.87 405.69 337.51 532.31 0.0 342.01 True False 368.96034647236985 315.776171733026 377.5195273903588 441.20087724624835 309.12881850892217 401.60912693704796 312.0513489691401 518.1914096134358 0.0 385.91031495951216 0.9560779594893165 0.8182631028303965 0.9782571565363997 1.1432730874077233 0.8010379783223842 1.0406799491202583 0.8086110603233786 1.3427767787647809 0.0 1.0 8.592121795825575 -8.251485630097621 24.98266464232797 0.49999994618742993 0.9752351049807432 0.33439097197178336 0.27399479626705037 638.7623961754978 1603223.6141210375 0.17193965952674328 0.0632717617100454 5.6042096022299324e-09 8.251485630097621 0.47523515879331324 HVVFIAQR ddPTM_A459_Selumetinib_30min_R1 2 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 ; 128.86 0.0059313000000000005 15508900.0 5203.3 5555.1 6201.0 6711.0 5373.700000000001 4480.7 5021.8 5284.7 3725.2000000000003 4360.0 False True 5324.526766140673 4904.706309504077 5358.938259654825 5539.049831072066 4887.64978380379 4435.628226150094 4643.001582925626 5144.532588875138 6321.392322156855 4919.648469996415 1.0822982167554247 0.9969627585012494 1.0892929225202812 1.1259035812930964 0.9934957372690801 0.901614872119781 0.9437669401059888 1.045711420287492 1.284927644873265 1.0 12.264339517155157 -11.055162736139795 5.412424935498985 0.999871221942202 1.0437844268609981 0.017567899198273285 0.1016801634989788 0.00016596175118062221 1.4341646264208725e-05 0.1034089367132344 0.02500685994632042 8.807187936748835e-12 11.055162736139795 0.043913204918796134 HVVFIAQR ddPTM_A459_Selumetinib_30min_R2 2 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 ; 115.46 0.013815 11008800.0 39430.0 40607.0 43135.0 45402.0 44224.0 35209.0 40040.0 40841.0 31888.0 41672.0 False True 37238.63845079618 43721.4263279156 40359.74106183699 39218.169277181485 38668.18575242377 40058.72015452053 41901.93933775484 40959.84054840848 38266.491025163494 40468.82108314108 0.9201809554642408 1.0803731158387888 0.997304591080625 0.9690959169927338 0.9555056143835274 0.9898662496795244 1.0354128985292033 1.0121332782158052 0.9455795845040058 1.0 15.304523201319835 -8.242215879841435 24.631573155406315 0.9727897739287699 0.9969058740453799 0.039214534092932296 0.04311153049905837 2093.5577648971084 2682545.8520232583 0.028968057377413654 0.010899324366821101 5.725113753126883e-09 8.242215879841435 0.02411610011661003 HVVS(ph)PEQIATSDK ddPTM_A459_Selumetinib_30min_R2 1 HVVSPEQIATSDK 13 0 Q9H582;Q9H582-2;A0A087WZL9 Q9H582 ZNF644 Zinc finger protein 644 1 HVVS(1)PEQIATSDK 71.781 0.037596 5808700.0 49060.0 48234.0 48153.0 41670.0 47330.0 39950.0 42867.0 45993.0 35770.0 43231.0 True False 46333.44160274055 51933.39270324528 45054.88840502226 35994.474115240555 41383.98226443144 45452.74987000756 44860.40043934906 46126.83201544894 42924.999497306184 41982.80870237265 1.1036289146638736 1.2370156811426072 1.0731747064477846 0.8573622210561233 0.9857363893353004 1.0826514774710347 1.0685421444138345 1.0987076244101337 1.0224423001713148 1.0 15.357511067509579 -5.513182358658093 24.959721388722862 1.0197115820841312 1.1665155499278541 0.42923326584527033 0.07029854791256514 439.0494091659727 1130166.7659670543 0.020277722676053725 0.03795287229310472 3.06773358784485e-06 5.513182358658093 0.14680396784372296 HWDQDDDFEFTGSHLTVR ddPTM_A459_Selumetinib_30min_R1 1 HWDQDDDFEFTGSHLTVR 18 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 144.68 0.00015952 3372100.0 1298.1 1535.3 1311.0 1398.7 1760.4 1197.9 1292.6 1128.5 611.64 910.93 False True 1328.3432043370958 1355.5463622583932 1132.9734008075277 1154.4433018507686 1601.1721308238632 1185.8502136061763 1195.09814132177 1098.5685141153876 1037.9084075818805 1027.8567387095948 1.292342750026372 1.3188086541711939 1.1022678143161273 1.1231558430021045 1.5577775292245761 1.153711571804191 1.1627088642938077 1.068795361009713 1.0097792508369454 1.0 10.005423482310508 -7.61133763211701 1.6252064301709257 1.0103185840044413 1.2621094255880292 0.4342300691828235 0.12095752234348581 0.40641478817550264 2.074568300377573 0.08844229327507601 0.03957925064152057 2.4471600146463048e-08 7.61133763211701 0.2517908415835879 HWDQNER ddPTM_A459_Selumetinib_30min_R2 6 HWDQNER 7 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 ;;;;; 119.41 0.014287 143432400.0 60557.2 35967.4 43086.53 57185.799999999996 47100.9 33777.659999999996 68906.2 60400.899999999994 46265.00000000001 37085.439999999995 False True 57191.67325367872 38725.983926580906 40314.38956886681 49396.99538899263 41183.66385461147 38430.22606193141 72110.474835045 60576.65661909268 55519.29275210707 36014.6869876551 1.5880097270672529 1.075283090475149 1.1193874760784548 1.3715791950635208 1.1435241369369158 1.0670709445594875 2.002251882954379 1.6819986979161248 1.541573657745176 1.0 15.136297745082302 -7.237253293939125 24.993353411360815 1.6132893812060052 1.2183789761057968 0.24572092614664987 0.2749818697536527 894.527701814771 924386.0251946276 0.10069198221629469 0.07795507555405007 5.790908542662523e-08 7.237253293939125 -0.39491040510020836 HWPFMVVNDAGRPK ddPTM_A459_Selumetinib_30min_R1 3 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ;; 106.79 0.0043105 29169000.0 20102.9 22710.6 26234.5 25217.1 23608.5 21232.1 21527.5 20594.3 12557.7 17624.7 False True 20571.258456565916 20051.632394128505 22671.998995793332 20813.40686859298 21473.11534341922 21018.524351204345 19903.663343110307 20048.072264285805 21309.499721880467 19887.00192411601 1.0344072241286475 1.0082782950713578 1.1400410721688565 1.0465834391735822 1.0797562863097934 1.0568975872484927 1.0008378044643367 1.0080992771451625 1.0715290219809082 1.0 14.279538177831421 -7.143958869682228 6.322130177692814 1.0209656919226697 1.062845136501914 0.22440233642230856 0.037244582791092315 0.38535145387984526 18.59037825246154 0.014490002774132236 0.011198005744347957 7.17862273957253e-08 7.143958869682228 0.04187944457924431 HWVAPGGPYSAETPGVPS(ph)PIAALK ddPTM_A459_Selumetinib_30min_R1 2 HWVAPGGPYSAETPGVPSPIAALK 24 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 HWVAPGGPYSAET(0.003)PGVPS(0.997)PIAALK;HWVAPGGPYSAETPGVPS(1)PIAALK 162.91 2.7451e-13 179975000.0 9574.0 11138.4 12164.3 13006.7 11803.7 9953.3 10853.7 10167.7 5454.1 8795.2 True False 9797.05557223893 9834.310949898325 10512.454873717017 10735.324010997632 10736.05741911249 9853.17883887332 10034.996670636001 9898.019566655763 9255.209348296929 9924.149592502867 0.9871934598446653 0.9909474719453635 1.0592801706313035 1.0817374235377872 1.081811324894072 0.9928486815955333 1.0111694283827475 0.9973670262017369 0.9325947036599201 1.0 13.276727766641269 -7.508262259190268 1.468386202759085 0.9707762947406637 1.037870935024221 0.3347683021633173 0.036511388118587874 0.5223844064323264 2.1613368138058697 0.027668972893424224 0.013251770619354487 3.102685390941461e-08 7.508262259190268 0.06709464028355727 HYCESLRPR ddPTM_A459_Selumetinib_30min_R1 1 HYCESLRPR 9 1 B4DEY6;Q9NZU5-2;Q9NZU5 B4DEY6 LMCD1 LIM and cysteine-rich domains protein 1 0 110.41 0.0086568 3548400.0 362.88 314.58 366.38 291.37 277.57 305.5 233.09 431.55 288.85 387.97 False True 371.33439795843566 277.7488273557256 316.6276083812828 240.48769919229164 252.4638425089636 302.4269473718066 215.50783363816447 420.10389212804233 490.1573532307014 437.76972864782346 0.8482413781907848 0.6344633015481267 0.723274332739446 0.549347484430014 0.5767046599790491 0.6908356781679227 0.49228582867943343 0.9596458243598819 1.119669363034059 1.0 8.774028386779694 -7.896643972695241 5.545569841982117 1.0531276392684077 0.6440970259576498 0.765693001250012 0.09755054359040406 0.09211134494255191 4.151612855006387 0.05434188952158265 0.02545642310274022 1.268691491591711e-08 7.896643972695241 -0.40903061331075785 HYEDGYPGGSDNYGS(ph)LSR ddPTM_A459_Selumetinib_30min_R1 4 HYEDGYPGGSDNYGSLSR 18 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 HYEDGYPGGSDNYGS(0.952)LS(0.048)R;HYEDGYPGGSDNYGS(0.999)LS(0.001)R;HYEDGYPGGSDNYGS(0.993)LS(0.007)R;HYEDGYPGGS(0.005)DNYGS(0.985)LS(0.01)R 308.24 2.3477999999999988e-111 167442000.0 14136.37 15789.400000000001 15107.509999999998 15964.179999999998 16075.240000000002 13927.950000000003 16791.030000000002 14252.63 7333.97 12711.33 True False 14465.719916412289 13940.76970770709 13055.993121612293 13176.335647772927 14621.23738031413 13787.847468566782 15524.469088564188 13874.603953333099 12445.211438024455 14342.953024339346 1.0085593874472443 0.9719595179632975 0.9102723197556919 0.9186626788370065 1.0194021660325143 0.9612976801338906 1.0823760673426082 0.967346398596476 0.8676882240990047 1.0 13.808054465999922 -4.77519712464146 5.56998357083023 0.9672265186184204 1.010096377720728 0.046767921094789444 0.05710296195031578 0.5438724654799727 53.04119540183171 0.01478235116590841 0.08662481038524607 1.6780421881649348e-05 4.77519712464146 0.04286985910230756 HYEDGYPGGSDNYGS(ph)LSR ddPTM_A459_Selumetinib_30min_R2 4 HYEDGYPGGSDNYGSLSR 18 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 HYEDGYPGGSDNYGS(0.993)LS(0.007)R;HYEDGYPGGSDNYGS(0.996)LS(0.004)R;HYEDGYPGGS(0.001)DNYGS(0.982)LS(0.018)R;HYEDGYPGGSDNYGS(0.999)LS(0.001)R 265.38 2.4517e-43 171440000.0 231867.0 178327.0 236675.0 267850.0 230824.0 202790.0 180065.0 201529.0 163524.0 196489.0 True False 218980.76037714322 192004.10748832035 221447.5881722565 231368.3679329776 201825.82552725807 230722.48175566547 188438.37929202846 202115.41602507827 196233.36924231134 190815.85203026718 1.1476025605168723 1.006227236602254 1.1605303533017295 1.2125217348099464 1.057699469828348 1.2091368683513166 0.9875404862177719 1.0592171136443043 1.0283913372730942 1.0 17.541821502674786 -7.277415161216635 24.989310150431677 1.023721991447779 1.1280969790316515 0.4464067208513476 0.06171627513101786 860.1669370370686 1345467.0138825832 0.02574556462075091 0.017418841093626247 5.279403290696706e-08 7.277415161216635 0.10437498758387243 HYELYR ddPTM_A459_Selumetinib_30min_R1 4 HYELYR 6 0 E7EW69;E7EX04;B5ME97;Q9P0V9;Q9P0V9-2;H0Y961;D6RDU5;B1AMS2;Q92599-3;Q14141-2;Q14141-4;Q9P0V9-3;Q14141;Q9NVA2-2;A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-2;Q92599-4;Q92599;D6RGI3;D6RER5;Q9NVA2 E7EW69;A0A087X142;D6RGI3 SEPT10;SEPT11;SEPT6;SEPT8 Septin-10;Septin-8;Septin-6;Septin-11 0 ;;; 159.65 0.0032997 18656400.0 2379.6400000000003 2660.6899999999996 3068.97 2402.68 2894.4500000000003 2611.92 2449.61 2131.13 1674.7199999999998 2072.41 False True 2435.0809820265963 2349.175177878776 2652.220730645519 1983.0970418894703 2632.6475085566526 2585.6464562336123 2264.833945507675 2074.6055095141583 2841.877523290702 2338.4240104828614 1.0413342366954983 1.0045976124722116 1.1341915404374683 0.8480485288380102 1.125821278243306 1.1057218214671436 0.9685300592855309 0.8871810673402095 1.21529607571207 1.0 11.191320832306783 -4.556608248719689 19.550378898316175 1.0289290862639981 1.0439863276910308 0.0 0.10908038090249596 79838691.87407404 6070557019.599609 0.026019516432253496 11000425.060460564 2.7758228807776624e-05 4.556608248719689 0.015057241427032686 HYELYR ddPTM_A459_Selumetinib_30min_R2 4 HYELYR 6 0 E7EW69;E7EX04;B5ME97;Q9P0V9;Q9P0V9-2;H0Y961;D6RDU5;B1AMS2;Q92599-3;Q14141-2;Q14141-4;Q9P0V9-3;Q14141;Q9NVA2-2;A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-2;Q92599-4;Q92599;D6RGI3;D6RER5;Q9NVA2 E7EW69;A0A087X142;D6RGI3 SEPT10;SEPT11;SEPT6;SEPT8 Septin-10;Septin-8;Septin-6;Septin-11 0 ;;; 164.83 0.00032268 27309400.0 18515.0 19620.100000000002 22474.899999999998 27612.699999999997 22751.5 14105.699999999999 18177.3 21716.8 18901.8 22446.5 False True 17486.010421417464 21124.89858143514 21028.8894028209 23851.80262543564 19893.25316900934 16048.632136204398 19022.58046763662 21779.99229259023 22682.68816041882 21798.411221989023 0.8021690316484419 0.9691026729565281 0.9646982612020883 1.0941991314199666 0.9126010591516015 0.7362294422639128 0.8726590334458734 0.999155033400773 1.0405661187608841 1.0 14.411935367501826 -7.881076736716307 5.884531948771609 1.0197393010943208 0.9130255360047496 0.21738719672164808 0.09204020793930899 0.3774254841764831 17.730326690356883 0.05701528734213387 0.026906730028889967 1.3149924619386314e-08 7.881076736716307 -0.1067137650895712 HYGDQVDR ddPTM_A459_Selumetinib_30min_R1 2 HYGDQVDR 8 0 E7ES68;G5E9D5;Q9BQ52-2;Q9BQ52;Q9BQ52-4;Q9BQ52-3 E7ES68;Q9BQ52-3 ELAC2 Zinc phosphodiesterase ELAC protein 2 0 ; 131.06 0.0051472 2110660.0 413.88 719.19 657.4200000000001 846.3700000000001 756.14 518.69 535.54 439.1 281.03 538.46 False True 423.5225987297103 634.9869004576395 568.1459749495688 698.5673678325836 687.7472705073594 513.4724495328392 495.14378663427243 427.4536416021861 476.88738438090354 607.5765860445573 0.6970686633711899 1.0451141716825014 0.9351018258427476 1.1497601847701113 1.131951570064161 0.8451155974848298 0.8149487620281017 0.703538700174398 0.7849008591419461 1.0 9.246922464077748 -6.926072050016684 7.936411850657992 0.8051771955033925 1.000136075072254 0.2549917538842207 0.13663467770261203 0.30977805188602336 29.018201647173893 0.048764595453139305 0.042984815990124846 1.1855720439142169e-07 6.926072050016684 0.1949588795688616 HYGDQVDR ddPTM_A459_Selumetinib_30min_R2 3 HYGDQVDR 8 0 E7ES68;G5E9D5;Q9BQ52-2;Q9BQ52;Q9BQ52-4;Q9BQ52-3 E7ES68;Q9BQ52-3 ELAC2 Zinc phosphodiesterase ELAC protein 2 0 ;; 149.82 0.0019281 9488500.0 8441.4 8713.53 8587.8 8449.58 8345.0 7640.0 6675.0 6616.17 5355.5 8271.8 False True 7972.26078160159 9381.829732585078 8035.270297689662 7298.732627661488 7296.626494753442 8692.340650985174 6985.400726261572 6635.421959334093 6426.749645172581 8032.971641282552 0.9924422912974122 1.167915206418825 1.0002861526854268 0.908596837333807 0.9083346513082493 1.082082825527982 0.8695911100149579 0.8260233268139205 0.8000463504868641 1.0 12.971718068054235 -5.8459558668126705 0.608187879477339 0.8781135127833264 1.1079542066905186 0.32220390817628075 0.08989604752674624 1.4789473166320057 0.9386928859418006 0.05900250926883211 0.2044405437280675 1.4257524718047048e-06 5.8459558668126705 0.2298406939071922 HYGGLTGLNK ddPTM_A459_Selumetinib_30min_R2 2 HYGGLTGLNK 10 0 P18669;Q8N0Y7;P15259 P18669 PGAM1;PGAM4;PGAM2 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4;Phosphoglycerate mutase 2 0 ; 152.11 0.00090787 16259500.0 177526.0 163413.0 181790.0 203466.0 211337.0 166419.0 143038.0 172684.0 136628.0 174941.0 False True 167659.81561288453 175946.25164438828 170093.82931798682 175753.57980157234 184786.95668324872 189341.70664873044 149689.55042441995 173186.48185062496 163957.41770528202 169889.99877869536 0.9868727813182462 1.0356480835201018 1.0011997795088396 1.034513985902814 1.0876859027114283 1.1144958974034342 0.8810968950527264 1.0194036323246063 0.9650798686440553 1.0 17.37424139972486 -7.25429188044799 24.99982150853706 0.9680120679182674 1.0427407709998322 0.37837251306961184 0.04833312369228643 656.9812763807413 2297927.9620757643 0.019234533404729335 0.014592349897100362 5.5681140158391785e-08 7.25429188044799 0.07472870308156476 HYGIT(ph)SPISLAAPK ddPTM_A459_Selumetinib_30min_R1 2 HYGITSPISLAAPK 14 0 P51003;G3XAH6;G3V457;G3V3I9;A0A0C4DGK1;P51003-2 P51003 PAPOLA Poly(A) polymerase alpha 1 HYGIT(0.5)S(0.5)PISLAAPK;HYGIT(0.489)S(0.489)PIS(0.022)LAAPK 248.36 5.4782e-27 148006000.0 8350.2 9271.8 9874.9 10787.8 9300.1 8198.5 9250.7 7620.8 4049.6000000000004 6527.200000000001 True False 8544.743413339203 8186.2533456571155 8533.942818942984 8903.913242086013 8458.907597066018 8116.030533642407 8552.912251218702 7418.671628152896 6871.875428918284 7365.029700312063 1.1601777265035542 1.1115031002943894 1.1587112565997382 1.2089446484796587 1.1485232159630812 1.1019684731615573 1.1612868649879724 1.0072833281091262 0.9330411021461484 1.0 12.846475627765239 -7.8425423470024604 4.095073600735004 0.9676324303889143 1.1496817271609012 0.8584861056987387 0.03184218234377497 0.0777358334570422 2.4462460078939707 0.019329825249843675 0.0088637610132191 1.4370029278517928e-08 7.8425423470024604 0.1820492967719869 HYGIT(ph)SPISLAAPK ddPTM_A459_Selumetinib_30min_R2 2 HYGITSPISLAAPK 14 0 P51003;G3XAH6;G3V457;G3V3I9;A0A0C4DGK1;P51003-2 P51003 PAPOLA Poly(A) polymerase alpha 1 HYGIT(0.929)S(0.07)PIS(0.001)LAAPK;HYGIT(0.499)S(0.499)PIS(0.002)LAAPK 256.13 2.0023e-28 92282000.0 115816.0 118277.0 127742.0 139833.0 147758.0 101753.0 111589.0 114798.0 90660.0 116958.0 True False 109379.41036818185 127348.46557950317 119523.21879497328 120787.50417462025 129195.31906672029 115768.55212823235 116778.10960940862 115132.04317416795 108794.53325204842 113581.1186466216 0.9630069827757879 1.1212115807356602 1.0523159149967434 1.0634470377987688 1.1374717964231207 1.0192587774066248 1.0281472044022884 1.0136547741915771 0.9578575607318554 1.0 16.793363500310164 -7.500601190173855 1.4698272996902428 0.9845984876557243 1.067421386808938 0.31646749177358136 0.04687609348367512 0.47834409112159204 1.984113254264647 0.031177756701860147 0.015034288824022123 3.157903174460714e-08 7.500601190173855 0.08282289915321361 HYNGEAYEDDEHHPR ddPTM_A459_Selumetinib_30min_R1 3 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 ;; 157.37 8.7607e-05 99934000.0 4092.81 4183.5599999999995 4728.47 4557.04 4369.89 3781.17 3277.27 3505.52 2290.3599999999997 2988.65 False True 4188.164509778064 3693.746850315721 4086.369745626521 3761.2385102352346 3974.634221066744 3743.1348628276687 3030.062885354785 3412.542222066258 3886.5736387241423 3372.272339416235 1.2419413642324824 1.0953287512227248 1.2117555565912277 1.1153424550777333 1.178621956065026 1.109974072697709 0.89852259259681 1.0119414681250194 1.1525088271479689 1.0 11.719505335431913 -7.017213348601272 15.182461220193106 1.0149508571675632 1.1620028000032674 0.5164816315856438 0.06962373549246158 3.8354624662084142 3382.106150871509 0.025599000355534175 0.02055191989707948 9.61139999183887e-08 7.017213348601272 0.14705194283570422 HYNGEAYEDDEHHPR ddPTM_A459_Selumetinib_30min_R2 4 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 ;;; 103.76 0.0020547 54418200.0 29558.0 25228.0 30908.8 29840.300000000003 35334.8 26635.299999999996 29226.98 35248.4 31912.9 33385.9 False True 27915.284690049033 27162.906479194604 28920.16145895693 25775.999662611302 30895.726526880062 30304.070803820076 30586.09248216216 35350.96700831326 38296.37172092765 32421.962320014416 0.860999233004988 0.8377934133378059 0.8919929390302268 0.7950166436008566 0.9529258661746025 0.9346772568763692 0.9433757334077538 1.090340142258778 1.1811861152305054 1.0 14.984683791308004 -7.397635917876293 1.1585512783008864 1.106187108811549 0.8596924918185638 0.7200120024198032 0.05887774350516127 0.2516895197743128 0.6422015870583997 0.042369877420249176 0.021550414578217936 4.0028017605075764e-08 7.397635917876293 -0.24649461699298514 HYS(ph)DHWEDER ddPTM_A459_Selumetinib_30min_R2 1 HYSDHWEDER 10 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 HY(0.001)S(0.999)DHWEDER 85.973 0.023623 5736200.0 92391.0 95832.0 116150.0 114500.0 114760.0 93496.0 105970.0 121270.0 100370.0 105520.0 True False 87256.27809047709 103182.00625155307 108677.03545455793 98904.90247648276 100342.82283258307 106374.22532781547 110897.81497557143 121622.87562267069 120446.80457211673 102473.36342611437 0.8515020408536785 1.0069153856353086 1.0605393618500338 0.9651766973355514 0.9792088351323857 1.038067081739868 1.0822111353408563 1.186873071755506 1.1753962253709143 1.0 16.644889423708037 -7.187785283677676 1.9645774690465532 1.1341672142692636 0.9791956350297064 0.46709850073163384 0.06899903599988327 0.29253153567943607 2.2115937978705205 0.0338259330199544 0.02273263882654006 6.489551993877832e-08 7.187785283677676 -0.15497157923955718 HYS(ph)PEDEPSPEAQPIAAYK ddPTM_A459_Selumetinib_30min_R1 2 HYSPEDEPSPEAQPIAAYK 19 0 A0A096LP25;Q6ZSR9 A0A096LP25 AAK1 Uncharacterized protein FLJ45252 1 HY(0.001)S(0.986)PEDEPS(0.013)PEAQPIAAYK;HY(0.001)S(0.942)PEDEPS(0.057)PEAQPIAAYK 75.773 0.0060128 12149400.0 3625.8 4416.6 3873.47 5113.8 4407.6 4083.8399999999997 4060.8 4088.3 2169.7999999999997 3457.2400000000002 True False 3710.2740854213403 3899.502418778364 3347.4740494476964 4220.770827914818 4008.9333582249847 4042.760277430041 3754.490586631165 3979.8650033300332 3681.9921240781546 3901.0104303693583 0.951105912595584 0.9996134305155263 0.8581043576268389 1.0819686087112523 1.0276653779275868 1.036336700347469 0.9624405403796061 1.0202138841636494 0.9438560059757476 1.0 11.929632140451384 -5.768408999163647 24.999999710640946 1.0110041476928602 0.9426084518160516 0.3267509454248244 0.04846775988068693 197.64248004967473 708945.1198787674 0.01351459615559778 0.02053467542407711 1.704476433066744e-06 5.768408999163647 -0.0683956958768086 HYSPEDEPS(ph)PEAQPIAAYK ddPTM_A459_Selumetinib_30min_R2 1 HYSPEDEPSPEAQPIAAYK 19 0 A0A096LP25;Q6ZSR9 A0A096LP25 AAK1 Uncharacterized protein FLJ45252 1 HYS(0.005)PEDEPS(0.995)PEAQPIAAYK 62.847 0.020151 4972600.0 9323.9 9850.5 15272.0 18809.0 18735.0 14579.0 11038.0 12919.0 14252.0 17901.0 True False 8805.714964528994 10606.001675650321 14289.416146896358 16247.181752665205 16381.341806974922 16587.124915014763 11551.288871382063 12956.592151144421 17102.798234151727 17384.15161761635 0.5065369399796112 0.6100960178524131 0.8219794938060756 0.9345973338268064 0.9423147109678206 0.9541521081883619 0.6644723956316905 0.7453105815077435 0.9838155240673632 1.0 14.085485041845189 -5.200207944086279 2.546749122457921 0.8749733778868063 0.5171067127464144 0.6256997757355613 0.1018755655317377 0.21496960169099308 2.6182509333977513 0.029530094876570497 0.10878586179998646 6.306553087690136e-06 5.200207944086279 -0.3578666651403919 IAAPELHKGDS(ph)DS(ph)EEDEPTK ddPTM_A459_Selumetinib_30min_R2 1 IAAPELHKGDSDSEEDEPTK 20 1 Q92733 Q92733 PRCC Proline-rich protein PRCC 2 IAAPELHKGDS(1)DS(0.999)EEDEPT(0.001)K 69.72 0.034010000000000006 0.0 20887.0 20840.0 15261.0 18098.0 15577.0 12422.0 15922.0 14166.0 10408.0 15927.0 True False 19726.184157285803 22438.360988838413 14279.123874920464 15633.021179208627 13620.07799985314 14133.017744311226 16662.404548844464 14207.220714692457 12489.8908238178 15467.146126684305 1.2753603021344513 1.450711126994992 0.9231905975392425 1.0107243476699395 0.880581193731366 0.9137443733028805 1.0772772438024665 0.9185418304273861 0.8075110121491598 1.0 13.91691940641402 -5.267141886004485 24.9215006047408 0.9426993016484324 1.3630357268651583 0.8131743009760546 0.08082887618663631 153.75225986304022 671941.8403915418 0.02086833146019438 0.04543437808455522 5.405776848772417e-06 5.267141886004485 0.4203364252167259 IAAS(ph)FLK ddPTM_A459_Selumetinib_30min_R1 1 IAASFLK 7 0 Q68EM7-5;I3L460 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 IAAS(1)FLK 87.58200000000002 0.033402 4615500.0 919.95 1265.0 1196.4 1309.0 1321.0 1229.5 1069.9 950.68 485.19 917.68 True False 941.3830450889074 1116.8932119174547 1033.9354513547871 1080.407722973229 1201.5157832414932 1217.1323462966805 989.196581618568 925.4648781561517 823.331993124473 1035.4731669601633 0.9091332109092927 1.0786307627809575 0.9985149633477317 1.0433951911520605 1.160354340005527 1.1754359119414108 0.9553087546658022 0.8937603674202753 0.7951263435840904 1.0 10.016074453000728 -7.495988398894682 5.646045445852214 0.8896753447289237 1.0633240375856627 0.43921868413959 0.084744341625771 0.16659581794565922 16.482996859680465 0.03905047844954436 0.02470940069219014 3.1916231102970636e-08 7.495988398894682 0.173648692856739 IAASS(ph)SFR ddPTM_A459_Selumetinib_30min_R1 1 IAASSSFR 8 0 Q99961-3;Q99961-2;Q99961 Q99961-3 SH3GL1 Endophilin-A2 1 IAAS(0.11)S(0.692)S(0.198)FR 104.01 0.014949 168810000.0 8727.4 10610.0 11515.0 11796.0 10739.0 8872.6 8817.5 8496.3 5171.3 7191.3 True False 8930.731439435765 9367.77626754482 9951.326247367417 9736.05003834393 9767.659346124441 8783.349699676233 8152.388875990022 8270.950524128108 8775.318403191704 8114.373404193859 1.1006064171042433 1.1544669934345329 1.2263825870059346 1.1998523549966187 1.2037478261816363 1.08244337081365 1.0046849546973664 1.0192962675162722 1.0814536090557825 1.0 12.986263978133497 -6.928048533384905 3.976309835191123 1.0291475320839123 1.1793725135325681 0.7774267588570614 0.03815037127447609 0.10912476655776619 3.4128731499500837 0.015014533262193538 0.01296513119370838 1.1801887395366146e-07 6.928048533384905 0.15022498144865581 IAASS(ph)SFR ddPTM_A459_Selumetinib_30min_R2 2 IAASSSFR 8 0 Q99961-3;Q99961-2;Q99961 Q99961-3 SH3GL1 Endophilin-A2 1 IAAS(0.116)S(0.687)S(0.197)FR;IAAS(0.115)S(0.687)S(0.197)FR 99.013 0.018995 227350000.0 257620.0 265790.0 272490.0 335250.0 292190.0 206668.0 249840.0 236470.0 229415.0 217590.0 True False 243302.51173457014 286175.23835044965 254958.29006467934 289588.37166149257 255482.47998825775 235134.64105468607 261458.05504856817 237158.08855028424 275304.4103906761 211307.61133328525 1.1514138567910879 1.354306342988655 1.2065740957269446 1.3704587820300465 1.2090547916198704 1.1127599217607906 1.2373338253120616 1.1223357599562578 1.3028608323836088 1.0 17.688985208747134 -6.515067117500663 24.507201129757618 1.1670752851766435 1.2742908329688498 0.2401613681427449 0.09569481494679247 416.2731907917113 1305967.8420262847 0.02854070982907714 0.029806299868689715 3.054449030710492e-07 6.515067117500663 0.10721554779220632 IAASSS(ph)FR ddPTM_A459_Selumetinib_30min_R1 4 IAASSSFR 8 0 Q99961-3;Q99961-2;Q99961 Q99961-3 SH3GL1 Endophilin-A2 1 IAAS(0.025)S(0.141)S(0.834)FR;IAAS(0.034)S(0.214)S(0.752)FR;IAAS(0.032)S(0.204)S(0.764)FR;IAAS(0.034)S(0.214)S(0.752)FR 112.41 0.011184 268512400.0 24151.9 27587.0 31063.499999999996 31934.3 28186.5 25353.1 27004.5 23842.2 15451.2 18232.0 True False 24714.592278583383 24357.10121515163 26845.247319591617 26357.57398605346 25637.036051730767 25098.07083277297 24967.52882355232 23209.827405619748 26219.557889001946 20572.25479471895 1.2013555405179894 1.1839782006493658 1.3049248897346437 1.281219499226679 1.2461947563624376 1.2199961104514334 1.213650573196365 1.1282101858653766 1.2745106528494243 1.0 14.328412306756166 -12.695926156372028 0.2881720257777355 0.46912810276269135 1.2445079807603177 0.6580785706016276 0.049270446346535 46.66372126391856 1.1509043919701245 14.92885791406716 0.05632322240123444 2.0140666749981893e-13 12.695926156372028 0.7753798779976263 IAASSS(ph)FR ddPTM_A459_Selumetinib_30min_R2 2 IAASSSFR 8 0 Q99961-3;Q99961-2;Q99961 Q99961-3 SH3GL1 Endophilin-A2 1 IAAS(0.042)S(0.241)S(0.717)FR;IAAS(0.039)S(0.216)S(0.745)FR 90.601 0.028038 194790000.0 278953.0 267519.0 289371.0 310182.0 299068.0 218801.0 242945.0 229530.0 218230.0 239713.0 True False 263449.90899733576 288036.847090838 270753.18490332336 267934.67650620453 261496.40413815767 248938.85167227816 254242.42388638455 230197.8942992629 261882.09785566453 232791.86284082846 1.131697241400013 1.2373149283477463 1.1630697980558322 1.1509623800270243 1.123305604186672 1.069362342112835 1.0921448060245256 0.9888571339654635 1.1249624220530703 1.0 17.828681104657427 -6.55300832216861 0.9361773879240838 1.0438410707334886 1.1876626478104768 0.6177586508227202 0.04384278854573237 0.3476741772045617 0.6639877263183424 0.02245559319715958 0.025810821890157636 2.7989276846648453e-07 6.55300832216861 0.14382157707698817 IAAYGHEVGK ddPTM_A459_Selumetinib_30min_R2 2 IAAYGHEVGK 10 0 Q16719;B8ZZA3;A0A087X297;Q16719-2;A0A087WYM2 Q16719 KYNU Kynureninase 0 ; 130.66 0.0038527 18452700.0 171704.0 146437.0 167174.0 166083.0 175846.0 128586.0 137304.0 146099.0 126858.0 153188.0 False True 162161.37906557185 157668.2470308319 156418.2068452885 143462.20889084451 153754.6533968141 146297.55431251045 143688.90806271456 146524.12390200852 152233.14470867367 148765.06440977653 1.0900501385116528 1.0598472676120474 1.0514444870902704 0.9643541611065002 1.0335400586611763 0.9834133766079025 0.9658780348248995 0.98493637927252 1.023312464607579 1.0 17.182676242009315 -5.612574706612018 5.024448743182695 0.9932445413963746 1.0707372244030597 0.7049091746928537 0.0220556044501213 0.11026410765357877 4.662664120404794 0.006117357815552963 0.010882722367483994 2.4401992729301094e-06 5.612574706612018 0.0774926830066851 IACDEEFS(ph)DS(ph)EDEGEGGRR ddPTM_A459_Selumetinib_30min_R2 1 IACDEEFSDSEDEGEGGRR 19 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 2 IACDEEFS(1)DS(1)EDEGEGGRR 87.641 0.04572 0.0 11800.0 13997.0 14998.0 16796.0 12155.0 12926.0 10980.0 9093.8 7231.5 11437.0 True False 11144.20323914265 15070.524892551397 14033.045008587715 14508.355825283903 10627.980232921289 14706.439169454756 11490.59175645724 9120.261452440367 8678.002064992159 11106.784093105318 1.0033690351521787 1.35687565061309 1.2634660844176229 1.3062607235059296 0.9568908645229492 1.3240951697786194 1.0345561469579818 0.8211433098894836 0.7813244582992428 1.0 13.439153532501006 -7.545591057529642 3.907377214556926 0.8546329352263679 1.2050471199916553 0.5524420291396972 0.13489443941762383 0.15547973198427803 5.291654462674517 0.06481059983088949 0.03719118424460672 2.847140784099164e-08 7.545591057529642 0.3504141847652874 IACDEEFS(ph)DSEDEGEGGRR ddPTM_A459_Selumetinib_30min_R2 1 IACDEEFSDSEDEGEGGRR 19 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 IACDEEFS(0.999)DS(0.001)EDEGEGGRR 98.188 0.00075795 29213000.0 42357.0 47675.0 46588.0 52147.0 54509.0 38008.0 36557.0 43630.0 28786.0 49867.0 True False 40002.967508505535 51331.51920071357 43590.578801179116 45044.48864140747 47661.09210335717 43243.25699772834 38256.972936321275 43756.95607666468 34544.0043480418 48427.21013997398 0.8260431974685509 1.0599726693390963 0.9001257490403626 0.9301483300650794 0.9841800088338267 0.8929537107906497 0.7899891987530016 0.9035613645756095 0.7133180756891804 1.0 15.563530272161534 -6.998355197079199 7.837135555917019 0.843258150125405 0.9435940017722797 0.17760121428768527 0.08888678513368142 0.17597164283058456 90.07546170464661 0.02990841858504349 0.025291897310080597 1.0037944795645336e-07 6.998355197079199 0.10033585164687475 IACDEEFSDS(ph)EDEGEGGRR ddPTM_A459_Selumetinib_30min_R2 1 IACDEEFSDSEDEGEGGRR 19 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 IACDEEFS(0.49)DS(0.51)EDEGEGGRR 91.067 0.0013111 16165000.0 30571.0 30662.0 39611.0 38969.0 39208.0 25264.0 36157.0 34304.0 32586.0 29253.0 True False 28871.986205409306 33013.67680613066 37062.471385195895 33661.35497472544 34282.34051603272 28743.886676242077 37838.372143736284 34403.81896066708 39104.11052891302 28408.389881578187 1.0163189932890828 1.1621101000003817 1.304631186057805 1.1849089341227892 1.2067681645788582 1.0118097785922548 1.3319435667233326 1.2110443113489058 1.376498657330475 1.0 14.794029444949146 -7.293462167023133 24.996180236311865 1.2474586286460871 1.1599117237998724 0.08432034783681908 0.12356085068811971 1623.2483735708174 1267059.8008025992 0.05026063991361852 0.03388799048216242 5.0878914019254926e-08 7.293462167023133 -0.08754690484621475 IACEEEFS(ph)DSEEEGEGGRK ddPTM_A459_Selumetinib_30min_R1 2 IACEEEFSDSEEEGEGGRK 19 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 IACEEEFS(0.97)DS(0.03)EEEGEGGRK;IACEEEFS(0.999)DS(0.001)EEEGEGGRK 126.26 0.00019114 23938000.0 2581.8 2515.6099999999997 2503.5 2952.0 2501.4 2082.48 2368.34 2415.8599999999997 1126.47 1876.51 True False 2641.9509166917146 2221.0812117246396 2163.5384507411472 2436.488615902957 2275.1488116580394 2061.532141940555 2189.694207038528 2351.783544980771 1911.537315886405 2117.3783372552693 1.2477462672620152 1.0489770168347896 1.0218005977834432 1.1507100894691056 1.074512179343105 0.9736248386355425 1.0341534946829583 1.110705396197336 0.9027849592361026 1.0 11.048063360580333 -4.761810418052555 5.948760533111047 1.0406544176375674 1.2555868720524619 0.4805554755869843 0.06611928368449178 0.12053979220294467 16.120661655617106 0.016221131054051204 0.10586134998485476 1.7305716383084413e-05 4.761810418052555 0.2149324544148945 IACEEEFS(ph)DSEEEGEGGRK ddPTM_A459_Selumetinib_30min_R2 2 IACEEEFSDSEEEGEGGRK 19 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 IACEEEFS(0.937)DS(0.063)EEEGEGGRK;IACEEEFS(0.934)DS(0.066)EEEGEGGRK 104.3 0.00047282 15932000.0 25093.0 24400.0 25279.0 24731.0 25967.0 15906.4 16309.7 17425.2 15172.5 20841.5 True False 23698.431515237848 26271.401541634204 23652.57666169415 21362.595136645396 22704.793312074613 18097.3622160773 17068.133367057446 17475.904447102857 18207.423955070666 20239.75174227982 1.1708854840216751 1.2980100683129712 1.1686199002275859 1.0554771327565255 1.1217920852579157 0.8941494167773227 0.8432975653255161 0.8634446049353746 0.8995873164311733 1.0 14.304903973811992 -6.35249991478671 1.0774125286905163 0.8821457735837623 1.2273135526962244 0.7919606333797673 0.06748420001248845 0.20973045017669678 0.5121499240107054 0.030586258729870905 0.042049657909460345 4.44119748506694e-07 6.35249991478671 0.3451677791124621 IACKS(ph)PPPESMDTPTSTR ddPTM_A459_Selumetinib_30min_R1 1 IACKSPPPESMDTPTSTR 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IACKS(0.999)PPPES(0.001)MDTPTSTR 62.525 0.022857 7714300.0 2038.2 4285.5 2872.2 4160.9 2862.1 2770.4 2821.2 2167.8 1356.5 2016.8 True False 2085.6860943531838 3783.7516677251033 2482.171015865277 3434.2769247664687 2603.2235603447975 2742.53229132194 2608.3946126388482 2110.3029019932096 2301.8814251599315 2275.67592529559 0.9165127912851967 1.6626935433408112 1.090740112981098 1.5091238987908118 1.143934218140776 1.2051506371522165 1.1462065330326159 0.9273301521257251 1.011515479674874 1.0 11.152079405462047 -7.301504108468139 1.2080860236613336 0.9710378715538927 1.2964815752964078 0.2708259418116389 0.19896880452034563 0.5715323972194827 1.6138723440806235 0.12477892987032366 0.06897020914225269 4.9945445529805954e-08 7.301504108468139 0.3254437037425152 IACKS(ph)PPPESVDTPTSTK ddPTM_A459_Selumetinib_30min_R1 2 IACKSPPPESVDTPTSTK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IACKS(0.971)PPPES(0.029)VDTPTSTK;IACKS(1)PPPESVDTPTSTK 141.79 0.00016873 111000000.0 8661.8 26627.1 15170.599999999999 22639.5 14222.5 14581.5 15398.3 10689.3 5683.4 11876.6 True False 8863.603087071147 23509.586753397052 13110.515846140866 18685.936321048444 12936.077386186325 14434.823348942711 14236.793833757538 10405.785040260176 9644.314700887544 13401.0772978806 0.661409742668445 1.7543057345930784 0.978318052699712 1.394360759638604 0.9653013036669958 1.0771390260711056 1.0623618920554325 0.7764886963159198 0.7196671197779604 1.0 13.710061361563655 -7.199799303193504 1.0480845211917924 0.8199954144755265 1.206277361715762 0.1785388006936388 0.2814108088326904 0.7764678770325834 1.6814370494171784 0.1836820856231056 0.11002439865766865 6.312489908016157e-08 7.199799303193504 0.38628194724023557 IACKS(ph)PPPESVDTPTSTK ddPTM_A459_Selumetinib_30min_R2 4 IACKSPPPESVDTPTSTK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IACKS(1)PPPESVDTPTSTK;IACKS(0.996)PPPES(0.004)VDTPTSTK;IACKS(1)PPPESVDTPTSTK;IACKS(0.996)PPPES(0.004)VDTPTSTK 131.41 0.00029365 135375000.0 367422.0 445706.0 415714.0 264768.0 267010.0 200784.0 229909.0 234558.0 168699.0 394525.0 True False 347002.1561468029 479890.2170293279 388967.41383518005 228706.14164972462 233465.8167003134 228440.17346432013 240600.22405604055 235240.52494683268 202443.51384389325 383134.03815094713 0.9056938867177627 1.2525387181607204 1.015225417486751 0.596935064170986 0.6093580665060423 0.5962408732118948 0.627979245115384 0.6139901484142023 0.5283882236642586 1.0 18.54748967688917 -5.706648448714043 5.02775095662203 0.6314474765024886 1.088837268880016 0.6166931903144752 0.14557983647664757 0.10896589410512748 5.6955105593312005 0.03698802806283334 0.06415484609901503 1.9649502147550086e-06 5.706648448714043 0.4573897923775275 IACKS(ph)PQPDPVDTPASTK ddPTM_A459_Selumetinib_30min_R2 4 IACKSPQPDPVDTPASTK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IACKS(1)PQPDPVDTPASTK;IACKS(1)PQPDPVDTPASTK;IACKS(0.844)PQPDPVDT(0.054)PAS(0.08)T(0.022)K;IACKS(1)PQPDPVDTPASTK 106.31 0.00091827 31751500.0 257329.0 376953.0 305472.0 152887.0 163363.0 141260.0 145202.0 142890.0 100421.0 314375.0 True False 243027.6843496052 405864.0830050674 285818.26409276633 132063.52685521418 142839.87945625017 160717.28276939335 151954.1807123046 143305.78624328724 120508.00599717617 305298.17690565606 0.7960338538959116 1.32940224903632 0.9361938121926308 0.4325722747306963 0.4678700701851583 0.5264272600588066 0.4977238392067498 0.4693961414894787 0.39472232431448756 1.0 18.21985944892411 -5.6553976893719975 4.674650593691812 0.5143645729858931 1.0771016491458076 0.5427377033859391 0.20192989694711838 0.13141951866832416 4.802125452753135 0.05127803651474644 0.090886448954218 2.211069076230161e-06 5.6553976893719975 0.5627370761599145 IADGVNEINTENMVSSIEPEKQDS(ph)PPPKPPR ddPTM_A459_Selumetinib_30min_R1 2 IADGVNEINTENMVSSIEPEKQDSPPPKPPR 31 2 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 IADGVNEINTENMVS(0.101)S(0.101)IEPEKQDS(0.798)PPPKPPR;IADGVNEINTENMVS(0.049)S(0.049)IEPEKQDS(0.901)PPPKPPR 77.907 8.974800000000001e-06 64021000.0 4249.700000000001 5350.1 6097.7 6437.1 4850.299999999999 4830.7 4346.3 5053.0 2777.07 4730.4 True False 4348.709741523268 4723.70780480599 5269.665832268543 5312.981324332292 4411.591221390015 4782.107543924666 4018.455091773794 4918.978025542801 4712.484960832208 5337.592917997948 0.814732372500675 0.8849883978371628 0.9872738354586093 0.9953890088577818 0.826513240924476 0.8959296104803669 0.7528590421768352 0.9215723456459916 0.8828857938832458 1.0 12.381973564368149 -3.3894775966548147 15.430394347117065 0.8930821229403427 0.3809634716485959 0.0 0.0787350597645013 0.0 0.0 0.01832505211500408 0.0 0.0004078706014818228 3.3894775966548147 -0.5121186512917468 IADGVNEINTENMVSSIEPEKQDS(ph)PPPKPPR ddPTM_A459_Selumetinib_30min_R2 2 IADGVNEINTENMVSSIEPEKQDSPPPKPPR 31 2 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 IADGVNEINTENMVS(0.012)S(0.012)IEPEKQDS(0.976)PPPKPPR;IADGVNEINTENMVS(0.015)S(0.039)IEPEKQDS(0.946)PPPKPPR 91.617 1.7855e-07 22727300.0 51389.0 40110.0 42565.0 44401.0 39948.0 31804.0 40187.0 36530.0 27259.0 37130.0 True False 48533.005106466226 43186.308026022474 39826.41424126792 38353.507204002795 34929.37510034878 36184.71231203304 42055.7751290298 36636.296252132954 32711.561680096973 36057.96042467435 1.345971999937502 1.1976913701549858 1.1045110087262404 1.0636626906317643 0.9687007997392642 1.0035152262043074 1.1663381576139056 1.0160390610186274 0.9071938982359233 1.0 15.138030174311236 -4.67792637336227 0.9057638074315912 1.0166286458443468 1.5796538102710231 0.7461843378032735 0.0619972689331398 1.3853498356733263 0.785779844663172 0.022996523620716122 0.8086704898679465 2.0992957504215975e-05 4.67792637336227 0.5630251644266764 IADMGHLK ddPTM_A459_Selumetinib_30min_R1 1 IADMGHLK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 111.95 0.015992 6589700.0 5214.0 5712.4 5451.9 5623.0 5657.2 5104.9 5265.8 5210.4 3225.7 4727.8 False True 5335.476055322099 5043.589552377289 4711.561925143063 4641.048606782632 5145.507258859784 5053.549340878343 4868.596466480099 5072.2032662355505 5473.777304193434 5334.659182671802 1.000153125555415 0.945438008253653 0.8831983007363052 0.8699803394859458 0.9645428288227996 0.9473050044684076 0.9126349593793016 0.950801746194252 1.0260781648382562 1.0 12.381180388668588 -8.136792465655985 4.155819717984772 1.0123337522747298 0.930089383404222 0.43520177452305986 0.03628047843888359 0.22585970674804906 6.295598216493583 0.029062338798712808 0.01003880235648129 7.298061761238743e-09 8.136792465655985 -0.08224436887050779 IADMGHLK ddPTM_A459_Selumetinib_30min_R2 1 IADMGHLK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 111.95 0.015992 6678200.0 124420.0 110830.0 128120.0 137870.0 134570.0 108760.0 111980.0 123180.0 94852.0 114250.0 False True 117505.23449272287 119330.30462538211 119876.89868650852 119091.86816098435 117664.11352893607 123740.70277501925 117187.29188416037 123538.43340645336 113825.05038631463 110951.30564285035 1.059070317486569 1.075519606858017 1.0804460388450898 1.0733705878535424 1.0605022883434476 1.115270361696668 1.0562047125554657 1.113447315384649 1.025900954718954 1.0 16.759567119289287 -8.463234836967024 5.436931812571793 1.0002087229124683 1.0785881932644128 0.6574286551593663 0.01956199842261626 0.1006027537932641 5.837098897787858 0.01748341371974179 0.00454061848974433 3.441637800356687e-09 8.463234836967024 0.07837947035194448 IADPEHDHTGFLTEY(ph)VATR ddPTM_A459_Selumetinib_30min_R1 1 IADPEHDHTGFLTEYVATR 19 0 B3KR49;E9PJF0;E9PQW4;P27361-2;P27361-3;P27361 B3KR49 MAPK3 Mitogen-activated protein kinase;Mitogen-activated protein kinase 3 1 IADPEHDHTGFLT(0.312)EY(0.665)VAT(0.022)R 135.79 0.0012043 5647600.0 390.3 530.49 943.89 959.27 1134.8 1735.3 2977.9 3718.5 2324.7 1299.1 True False 399.39323060840314 468.3799841818897 815.7149224166417 791.7515022280586 1032.157540365213 1717.8444575263354 2753.274605478957 3619.8733006097223 3944.8461106297764 1465.8521393055828 0.2724648823022542 0.3195274418358287 0.5564783108363643 0.5401305363603279 0.7041348255317049 1.1719084152240136 1.8782758039861127 2.469466874281442 2.691162365461066 1.0 10.51752387063796 -7.052820918619582 1.6282555175939983 2.191984497814639 0.43577132211871894 0.7373736694410673 0.4303297888212823 0.17697980974348043 0.940110444533667 0.20767474468831568 0.1496030340143927 8.854806626157e-08 7.052820918619582 -1.75621317569592 IAELEEEQSQGSTT(ph)NSDWMK ddPTM_A459_Selumetinib_30min_R2 1 IAELEEEQSQGSTTNSDWMK 20 0 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 IAELEEEQSQGS(0.014)T(0.211)T(0.738)NS(0.036)DWMK 104.45 0.0017191 0.0 9254.0 8388.7 6694.3 8435.2 9768.7 5740.7 5386.4 8609.1 6988.2 8901.2 True False 8739.699726697128 9032.08631607815 6263.596026202741 7286.3112084683735 8541.468572713955 6531.429316113954 5636.878272949113 8634.151055686774 8386.035266622168 8644.199227904963 1.0110479289375787 1.0448725298835109 0.7246010718937128 0.8429133822999946 0.9881156539220689 0.7555852362853203 0.652099532221828 0.9988375820647735 0.9701344272064673 1.0 13.077516607877351 IAELEEEQSQGSTTNS(ph)DWMK ddPTM_A459_Selumetinib_30min_R1 3 IAELEEEQSQGSTTNSDWMK 20 0 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 IAELEEEQSQGST(0.001)T(0.002)NS(0.997)DWMK;IAELEEEQSQGS(0.002)T(0.008)T(0.173)NS(0.817)DWMK;IAELEEEQSQGS(0.109)T(0.076)T(0.291)NS(0.523)DWMK 161.56 4.614100000000001e-07 13705800.0 5361.81 7444.5 6995.49 6328.759999999999 5675.71 6200.75 5839.219999999999 6139.8 3463.8299999999995 5174.83 True False 5486.7297407339065 6572.8944791458425 6045.540881476012 5223.560871538619 5162.3430326279895 6138.376084830536 5398.762934217004 5976.952559118885 5877.866521866361 5839.069837612742 0.9396581807243999 1.1256749211674302 1.0353602627824852 0.8945878396402654 0.8841036631167565 1.0512592340118614 0.924592971887496 1.0236138161283777 1.00664432612258 1.0 12.511522851105898 -5.557904557015671 24.5919851095586 0.9679969986004537 1.0446293652096859 0.15883480287096374 0.06666474020558412 222.88710987957438 156490.27133866024 0.01804820841451994 0.03126064298844332 2.767549790805136e-06 5.557904557015671 0.07663236660923212 IAEPS(ph)VCGR ddPTM_A459_Selumetinib_30min_R1 2 IAEPSVCGR 9 0 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IU45 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 IAEPS(1)VCGR;IAEPS(1)VCGR 125.68 0.0049856 16424300.0 8977.5 9890.1 9074.400000000001 8877.3 9224.7 7897.7 10162.099999999999 9513.5 6179.1 9516.3 True False 9186.658282825882 8732.162494217253 7842.146322111238 7327.04620255939 8390.327513753064 7818.256308537854 9395.564615446354 9261.171075796843 10485.48139639199 10737.80980161167 0.8555430253054984 0.8132163500331899 0.7303301573598545 0.6823594697551498 0.7813816475398675 0.7281053075986119 0.8749982341870263 0.8624823168693868 0.9765009429407283 1.0 13.390412135388269 -7.914494873101634 1.2071052408242908 0.9983050419269447 0.7632054231643567 0.7393102602151945 0.05076393479181803 0.2529587283628937 0.6640979660043511 0.04819934231848045 0.017358823196484862 1.217601366690356e-08 7.914494873101634 -0.235099618762588 IAEPS(ph)VCGR ddPTM_A459_Selumetinib_30min_R2 2 IAEPSVCGR 9 0 A0A3B3ITP6;A0A3B3IT92;P33991;A0A3B3IU45 A0A3B3ITP6 MCM4 DNA replication licensing factor MCM4 1 IAEPS(1)VCGR;IAEPS(1)VCGR 115.23 0.0082322 12928100.0 37961.0 32323.0 43227.0 48533.0 43716.0 34363.0 33950.0 36342.0 36529.0 39043.0 True False 35851.27958992325 34802.07016517389 40445.821881999 41922.7216759052 38224.00525400139 39096.191333743904 35528.74227064874 36447.749203258005 43835.820705538084 37915.72714410343 0.9455516823840938 0.9178795393506315 1.066729426770048 1.1056815953066834 1.0081306131549663 1.031133892939834 0.9370449928499944 0.961283138913143 1.156138204574967 1.0 15.210508770596148 -5.253193461107589 24.90976078592089 1.0300607084010471 0.9317155992942713 0.30109883002664506 0.06173291614240838 766.4365369668855 2315284.18320347 0.016333849841248905 0.041593494114624666 5.58221473635794e-06 5.253193461107589 -0.09834510910677585 IAESNHIK ddPTM_A459_Selumetinib_30min_R2 1 IAESNHIK 8 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 91.069 0.038474 3260600.0 29807.0 25258.0 32419.0 39590.0 51011.0 25912.0 31069.0 36732.0 36463.0 45780.0 False True 28150.446266874995 27195.20738272938 30333.196835138373 34197.77370344069 44602.54213587395 29481.14279428373 32513.770062055566 36838.884038690056 43756.61886134397 44458.21244927525 0.6331888916809992 0.611702672790946 0.6822855702924885 0.7692116218675854 1.0032464122745235 0.6631202913954388 0.7313332738951721 0.828618201434021 0.9842190329012495 1.0 15.440162322012181 -3.4621754462655168 0.13118903457593448 1.0789961983239829 4.94511022700359e-13 0.547234965570528 0.09906085262543708 42.986209302308104 0.6301965351878999 0.6778576478900135 8.133585178021727 0.00034500433634326687 3.4621754462655168 -1.0789961983234884 IAFDAESDPSNAPGS(ph)GTEK ddPTM_A459_Selumetinib_30min_R1 1 IAFDAESDPSNAPGSGTEK 19 0 Q5JVZ5;Q96JJ3;H0YCM7;Q96JJ3-3;Q5JVZ8 Q5JVZ5 ELMO2 Engulfment and cell motility protein 2 1 IAFDAESDPS(0.002)NAPGS(0.576)GT(0.422)EK 142.58 8.776799999999999e-05 5056000.0 539.92 623.82 746.98 713.39 552.87 704.9 724.29 831.51 381.69 443.42 True False 552.4990854985631 550.7828643939497 645.5442188674348 588.809828488825 502.8630061171263 697.8093459979912 669.6562221707752 809.4556536748661 647.7000524653843 500.33727627656225 1.1042532941182825 1.1008231657109304 1.2902181178094136 1.1768258261120632 1.0050480545030747 1.3946779084520498 1.3384096167174673 1.6178200027363905 1.2945268785197748 1.0 8.966757130204453 -6.780740598339403 24.996563410392277 1.3682833715285032 1.1444095721564944 0.25508589969461604 0.15816929100093 287.9689127665488 372939.4276852254 0.05389999873053773 0.04760561927859622 1.656759241006634e-07 6.780740598339403 -0.2238737993720088 IAKEEIFGPVQQIMK ddPTM_A459_Selumetinib_30min_R2 1 IAKEEIFGPVQQIMK 15 1 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 129.01 0.002595 16479000.0 54679.0 59041.0 57521.0 60928.0 46894.0 38593.0 35843.0 33038.0 21247.0 56711.0 False True 51640.160077379725 63569.254853263374 53820.16148412946 52629.50129333753 41002.75648232091 43908.835437627095 37509.77052155709 33134.13511026469 25496.993690781757 55073.60607712645 0.9376571420629612 1.154259896550798 0.9772405570965947 0.9556211231135631 0.7445082935898483 0.7972754748642401 0.6810843377320793 0.6016336584872037 0.4629621248166523 1.0 15.749073455066778 -6.305468678667168 1.124820710337067 0.6621986870393796 1.053278715833561 0.5120052734620569 0.13980115863833853 0.3583648394091011 0.9436067866518869 0.05875513505087294 0.08374883771374338 4.949158029777876e-07 6.305468678667168 0.39108002879418147 IALESEGRPEEQMESDNCS(ph)GGDDDWTHLSSK ddPTM_A459_Selumetinib_30min_R1 3 IALESEGRPEEQMESDNCSGGDDDWTHLSSK 31 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 IALESEGRPEEQMES(0.001)DNCS(0.993)GGDDDWT(0.006)HLSSK;IALESEGRPEEQMES(0.01)DNCS(0.947)GGDDDWT(0.038)HLS(0.003)S(0.001)K;IALES(0.002)EGRPEEQMES(0.073)DNCS(0.895)GGDDDWT(0.03)HLSSK 101.08 8.8529e-09 57731700.0 8452.5 8489.8 7427.0 7325.4 14680.0 8037.099999999999 11121.4 7592.6 2301.41 4051.67 True False 8649.426804298048 7495.81026919906 6418.454193590776 6046.156404788458 13352.196591964503 7956.2540711029305 10282.503844109495 7391.219583759412 3905.3246816640753 4571.741311107883 1.8919326829107064 1.6395963286432274 1.4039408087233558 1.322506238508774 2.9205932014400933 1.7403115202016688 2.2491438479089507 1.6167186813044494 0.8542313346066571 1.0 12.158528056600199 -8.152878496891447 4.009453725969224 0.9286068200499114 1.869910261668483 0.43066711602475827 0.43100752725877467 0.23060215852269147 6.204775540656557 0.34351267704334537 0.11651122430192255 7.032690468211395e-09 8.152878496891447 0.9413034416185717 IALESEGRPEEQMESDNCS(ph)GGDDDWTHLSSK ddPTM_A459_Selumetinib_30min_R2 4 IALESEGRPEEQMESDNCSGGDDDWTHLSSK 31 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 IALESEGRPEEQMES(0.036)DNCS(0.964)GGDDDWTHLSSK;IALESEGRPEEQMES(0.002)DNCS(0.998)GGDDDWTHLSSK;IALES(0.006)EGRPEEQMES(0.31)DNCS(0.681)GGDDDWT(0.002)HLSSK;IALESEGRPEEQMES(0.225)DNCS(0.774)GGDDDWT(0.001)HLSSK 89.71 3.1213000000000003e-07 66978300.0 69450.3 63447.6 120381.0 171107.0 185816.0 131702.0 102251.1 109584.0 149552.0 154028.0 True False 65590.53035757877 68313.82690381119 112635.8175209229 147801.93142396145 162472.13286388325 149842.75502827863 107005.97875671074 109902.87129739232 179466.5788320139 149580.81142719433 0.4384956180659826 0.4567018072171755 0.7530098041736207 0.9881075654941294 1.0861829890725223 1.001751184517486 0.7153723645147754 0.7347391035573135 1.1997967996006353 1.0 17.19056558927206 -5.414478985758057 2.6594976816708455 0.9456580325650502 0.435704979920019 0.6833040314035606 0.1385337883296865 0.17302980986998534 2.3415787751871053 0.0410304948778625 0.10430571536143941 3.850534458398372e-06 5.414478985758057 -0.5099530526450312 IALESEGRPEEQMESDNCSGGDDDWT(ph)HLSSK ddPTM_A459_Selumetinib_30min_R1 1 IALESEGRPEEQMESDNCSGGDDDWTHLSSK 31 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 IALESEGRPEEQMESDNCS(0.001)GGDDDWT(0.991)HLS(0.004)S(0.004)K 89.08 4.6493e-07 23490000.0 854.62 891.57 678.38 620.19 735.24 725.66 707.14 728.29 285.6 672.9 True False 874.5309831989592 787.1845699203516 586.2597220746071 511.88545890814873 668.737671817165 718.3605192465631 653.79986047832 708.9733833806787 484.64234060130946 759.2732696010521 1.151800041187368 1.0367605464814598 0.772132703134206 0.6741781640450883 0.8807601934525398 0.946115908471286 0.8610863659428557 0.9337525918082132 0.6382976459265541 1.0 9.568475408410935 -5.080848539855257 3.9137220805296193 0.8369654869185009 1.133194210400824 0.4753515963378707 0.11032269889697592 0.18529866876058762 5.182476438618738 0.028711091689104594 0.09547825596737732 8.301402283347088e-06 5.080848539855257 0.296228723482323 IALESEGRPEEQMESDNCSGGDDDWT(ph)HLSSK ddPTM_A459_Selumetinib_30min_R2 2 IALESEGRPEEQMESDNCSGGDDDWTHLSSK 31 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 IALESEGRPEEQMES(0.012)DNCS(0.004)GGDDDWT(0.979)HLS(0.003)S(0.003)K;IALES(0.014)EGRPEEQMES(0.024)DNCS(0.067)GGDDDWT(0.889)HLS(0.004)S(0.002)K 65.125 0.00022437 12963700.0 16495.9 13627.8 17599.8 23307.6 27895.8 19845.8 18103.3 16554.5 14981.6 20084.6 True False 15579.123916319759 14673.00843971651 16467.44802921337 20133.064672147364 24391.28021238383 22579.378807764602 18945.139321008424 16602.670854255 17978.338620879007 19504.705411942192 0.798736693904697 0.7522804436068351 0.8442807866829307 1.0322157780358192 1.2505331250709237 1.1576375203257299 0.9713112257214015 0.8512136176170928 0.9217436634480707 1.0 14.251534588425148 -5.673901766132456 3.874137291758499 1.0331153584685078 0.7807959511451982 0.4930061559326495 0.10709328079822887 0.21288672193810002 6.068381571474396 0.035130790689578084 0.06300812762267102 2.1188403454440965e-06 5.673901766132456 -0.2523194073233096 IALTDNALIAR ddPTM_A459_Selumetinib_30min_R2 1 IALTDNALIAR 11 0 A8MUD9;P18124 A8MUD9 RPL7 60S ribosomal protein L7 0 134.57 0.022229 3535300.0 12907.0 13440.0 14727.0 13581.0 15662.0 11184.0 10434.0 9998.8 10048.0 11605.0 False True 12189.680610814763 14470.804783588692 13779.480853545223 11731.244371468256 13694.399539943486 12724.494481756301 10919.201674578764 10027.894852609546 12057.88076457737 11269.9334965889 1.0816106957955205 1.2840186490868477 1.2226763234863716 1.0409328835009526 1.2151269165952405 1.129065622757016 0.9688789803314907 0.8897918391128675 1.0699158755663432 1.0 13.460191381800978 -7.1883811535244675 3.97699598399527 0.972203721832491 1.1709041893381757 0.5675087357534137 0.0773010805356139 0.16427994744787294 5.027105175051457 0.031205387125274677 0.023306160386357536 6.480654167785129e-08 7.1883811535244675 0.1987004675056847 IAQLEEELEEEQGNTELINDR ddPTM_A459_Selumetinib_30min_R1 1 IAQLEEELEEEQGNTELINDR 21 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 135.31 5.218e-05 1987100.0 698.43 789.17 684.61 653.2 969.35 713.3 722.67 604.35 528.68 721.79 False True 714.7020600917936 696.7736095248201 591.6437222935481 539.1308820825924 881.6724636526429 706.1248496245813 668.1584200750451 588.3206747945363 897.1313467405469 814.4387773299801 0.8775393313599839 0.8555260738064213 0.726443458688407 0.6619661257412806 1.082552167448459 0.86700789461365 0.8203912174534542 0.722363290121402 1.101533192809977 1.0 9.669662442899815 -8.27028457276462 24.99360639781039 1.0507666234724917 0.8285085197997947 0.3934047518088447 0.11126329379287725 766.9066281131666 2166998.89394471 0.10514011241627165 0.028775039377827234 5.366800199354018e-09 8.27028457276462 -0.22225810367269705 IAQLEEQLDNETK ddPTM_A459_Selumetinib_30min_R1 2 IAQLEEQLDNETK 13 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ; 263.44 7.240899999999998e-29 6760700.0 2386.3999999999996 2240.3999999999996 2019.9499999999998 2275.45 2911.5 2231.19 2093.03 2005.72 1656.6 2420.1 False True 2441.998476873926 1978.0929264662957 1745.6518847911245 1878.0853729865794 2648.1553390670747 2208.7462543584325 1935.1510619918793 1952.5217901032481 2811.1292067231416 2730.743408770258 0.8942614194475477 0.7243789072650714 0.6392588476766654 0.6877560765888077 0.9697561955334443 0.8088443049114974 0.7086535687596295 0.7150147406132646 1.029437331129212 1.0 11.415078043918692 -8.266570021157214 24.926973697292535 1.0147187121298205 0.7660806677627784 0.5185018736512551 0.09488898483399998 365.91564332018015 1777750.9668110264 0.08773324337906507 0.025359234435974654 5.4128996884232604e-09 8.266570021157214 -0.24863804436704207 IAQLEEQLDNETK ddPTM_A459_Selumetinib_30min_R2 1 IAQLEEQLDNETK 13 0 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 141.58 0.011371 3202500.0 29673.0 23720.0 27384.0 31792.0 30522.0 21428.0 21745.0 25052.0 19631.0 26723.0 False True 28023.8934504305 25539.247728178827 25622.143253444876 27461.874755740995 26687.553489857957 24379.51249598303 22756.18558690007 25124.89717241815 23557.74853596917 25951.43755530764 1.0798590016721057 0.9841168788337696 0.9873111344540751 1.0582024482156072 1.0283651313335345 0.93942820870811 0.8768757236820559 0.9681504972074103 0.9077627582581103 1.0 14.663526837071716 -6.778827860420783 6.831376459728806 0.9322029094326404 1.02475289487358 0.5389552286640544 0.040991705003473024 0.12030945981571455 23.162060571243963 0.013948909350479715 0.0127240443870629 1.6640721013203598e-07 6.778827860420783 0.09254998544093962 IAQLS(ph)ESPVILTPNAK ddPTM_A459_Selumetinib_30min_R1 1 IAQLSESPVILTPNAK 16 0 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 IAQLS(0.731)ES(0.218)PVILT(0.05)PNAK 142.57 0.00039403 15237000.0 2373.2 3709.5 3517.1 3648.8 2777.8 3275.9 2999.6 2584.6 1569.0 2829.2 True False 2428.4909425566548 3275.1900155002345 3039.497138047411 3011.605576458912 2526.5484804604225 3242.947420279218 2773.3377570081866 2516.0480120360053 2662.478404774002 3192.3553787417095 0.7607207389027791 1.025947811860212 0.9521174109523645 0.9433804257864168 0.7914370991666599 1.0158478726630522 0.8687434285907474 0.7881478449394078 0.8340169213314331 1.0 11.64040554856875 -7.502932452307855 24.54955427373048 0.8523385443193316 0.9194095059015204 0.0296661528412987 0.0949285395357579 1447.9142860893248 1782075.8012728812 0.038659735195860835 0.025658271032456725 3.140997188713697e-08 7.502932452307855 0.06707096158218873 IAQLS(ph)ESPVILTPNAK ddPTM_A459_Selumetinib_30min_R2 1 IAQLSESPVILTPNAK 16 0 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 IAQLS(0.539)ES(0.135)PVILT(0.326)PNAK 116.58 0.0019093 9466000.0 15979.0 14622.0 18693.0 14520.0 14034.0 13079.0 14831.0 13960.0 10719.0 14976.0 True False 15090.95114900511 15743.46038285966 17490.31273139952 12542.350951602893 12270.923454448159 14880.51353065904 15520.670887068982 14000.62128879759 12863.09951388384 14543.603967679042 1.0376349069008248 1.0825006248689881 1.2026120052683704 0.8623963482144019 0.8437333333414763 1.0231654797345093 1.0671818980743235 0.9626651908228422 0.8844506177746679 1.0 13.828097199152538 -5.763424894208399 24.999999962537807 0.9511468577846637 1.1050743185938334 0.4692925039238731 0.077203710526801 50.90436555321094 640961.1842657683 0.023366938611402235 0.03670189173139887 1.7241502354362446e-06 5.763424894208399 0.15392746080916975 IAQLSES(ph)PVILTPNAK ddPTM_A459_Selumetinib_30min_R2 1 IAQLSESPVILTPNAK 16 0 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 IAQLS(0.064)ES(0.562)PVILT(0.374)PNAK 199.05 8.728499999999998e-07 8055200.0 25272.0 24944.0 28449.0 25516.0 31795.0 21397.0 23030.0 25300.0 20284.0 27813.0 True False 23867.483411831614 26857.124592398533 26618.62231292917 22040.676782444873 27800.62784909357 24344.242527372997 24100.940633079274 25373.61881135954 24341.366782313613 27009.96642314751 0.8836546864929535 0.9943412802387643 0.9855111219285723 0.8160201474206957 1.0292729510862502 0.901305915971447 0.8922980597423029 0.939416895743135 0.9011994461960193 1.0 14.721204225942472 IAQLSESPVILT(ph)PNAK ddPTM_A459_Selumetinib_30min_R1 1 IAQLSESPVILTPNAK 16 0 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 IAQLS(0.001)ES(0.002)PVILT(0.998)PNAK 133.86 0.00117 14605000.0 2444.1 3173.6 3520.1 2943.4 2823.8 2489.4 2263.8 2500.4 1216.0 2052.8 True False 2501.04277460927 2802.0334366333855 3042.0897545252305 2429.3904444609648 2568.387788582381 2464.358896194355 2093.0397434041643 2434.0812695561503 2063.4631868739225 2316.296875965284 1.0797591623772302 1.2097039311792352 1.3133419062517548 1.048825161260277 1.1088335934969655 1.0639218667371246 0.9036146295072472 1.0508503011047672 0.8908457323778946 1.0 11.177604457693189 -6.61451743557296 1.1213650083802271 0.9633368406329493 1.1894137914604788 0.5664987389061638 0.07949478616688932 0.3507973746497892 0.9386366113223376 0.03912659412157293 0.04085433675796702 2.4293079109042376e-07 6.61451743557296 0.22607695082752943 IAQVS(ph)PGPR ddPTM_A459_Selumetinib_30min_R1 2 IAQVSPGPR 9 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 IAQVS(1)PGPR;IAQVS(1)PGPR 93.667 0.024264 149010000.0 3233.12 3394.9 3774.3 4549.1 3916.7 3133.3100000000004 3251.11 3406.63 1844.29 2653.01 True False 3308.4454054436083 2997.4235297538075 3261.7707907458826 3754.685082182974 3562.435176549549 3101.791746217855 3005.8761552163237 3316.27510610625 3129.625428387917 2993.549676005776 1.105191416050924 1.0012940669664117 1.0895996872508853 1.2542584852618057 1.1900371004709112 1.0361584346101462 1.0041176798599163 1.1078069399306174 1.045456320124844 1.0 11.547641495685346 -6.790987615138943 24.924243413904613 1.0432838695745341 1.1259052680797021 0.3036782006697879 0.06744535700908096 321.0585508674482 270814.00209641975 0.026806376348609395 0.023644533459666172 1.618126181407312e-07 6.790987615138943 0.08262139850516803 IAQVS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 1 IAQVSPGPR 9 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 IAQVS(1)PGPR 84.18799999999997 0.036903 43330000.0 93383.0 99727.0 98894.0 130160.0 99751.0 65249.0 80156.0 77894.0 74502.0 96280.0 True False 88193.14670176756 107375.74022715395 92531.26770764598 112431.9834614762 87219.38759474551 74236.45747855134 83883.41282610084 78120.65864395419 89404.481759807 93500.14623451757 0.9432407354803599 1.1484018426862515 0.989637679020935 1.202479225855687 0.9328262158647471 0.7939715654813101 0.8971473971356582 0.8355137589625959 0.9561961703841853 1.0 16.51268100093099 -6.503835943036033 23.501311129945485 0.8837747497446181 1.0702890125775273 0.47473704484370993 0.08691806649358609 267.4624788386039 330084.10892524483 0.02528256573872368 0.028166617550569102 3.1344695626256313e-07 6.503835943036033 0.18651426283290917 IAS(ph)DEEIQGTK ddPTM_A459_Selumetinib_30min_R1 6 IASDEEIQGTK 11 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK 240.18 1.6899e-10 1156804300.0 20411.699999999997 23277.7 23350.1 23865.2 21287.0 20789.9 24814.499999999996 23808.4 15096.869999999999 16743.600000000002 True False 20887.252895745707 20552.336062490875 20179.284672918253 19697.590825287007 19361.594608525098 20580.772481718875 22942.72228673144 23176.923891417635 25618.285758241218 18892.804156475217 1.1055665809454192 1.0878393642505884 1.0680936776662724 1.042597523488114 1.0248131748028104 1.089344509754267 1.2143629975049617 1.226759336489184 1.3559811209635044 1.0 14.20554922857043 -7.226445003677985 4.046236603175572 1.2196538864005015 1.0653160472626761 0.35387270187027775 0.08441789583758003 0.2111991592700063 7.760537863292078 0.033139358104000115 0.02414996407131713 5.9368352377930695e-08 7.226445003677985 -0.1543378391378254 IAS(ph)DEEIQGTK ddPTM_A459_Selumetinib_30min_R2 6 IASDEEIQGTK 11 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK;IAS(1)DEEIQGTK 217.46 1.7711e-05 1428955000.0 495270.0 492253.0 503193.0 513733.0 443829.0 363914.0 426860.0 476769.0 384874.0 575730.0 True False 467744.87612289697 530007.2222571352 470818.1102151147 443761.6791611442 388071.2331383975 414039.8502176201 446709.8358070431 478156.3188566434 461859.5542780607 559107.1789738141 0.8365925062550554 0.9479528115341158 0.8420891877640612 0.7936969794872333 0.6940909502372404 0.7405375316009164 0.7989699517486697 0.8552140570511936 0.8260662206587263 1.0 19.092765343824354 -10.517224992313807 10.196466668773441 0.9999992618389696 0.8140646610977836 0.42590197063145474 0.06441959928744696 5.055845767821993e-11 0.0 0.07136822016846586 0.017309335886289495 3.0393100607765337e-11 10.517224992313807 -0.18593460074118595 IAS(ph)PVSR ddPTM_A459_Selumetinib_30min_R1 3 IASPVSR 7 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 1 IAS(0.985)PVS(0.015)R;IAS(0.958)PVS(0.042)R;IAS(0.975)PVS(0.025)R 109.44 0.015842 89997000.0 4683.0 5235.9 5686.799999999999 6859.6 4846.1 4594.0 4554.3 4526.2 2584.55 3924.5 True False 4792.104788468236 4622.878393896129 4914.563795356404 5661.699630639543 4407.7711106484485 4547.788531018264 4210.7654843120345 4406.150472830366 4385.792581936674 4428.247802867186 1.0821672593312102 1.0439520550098673 1.1098213140137143 1.2785417353955952 0.9953758928744956 1.0269950403574248 0.9508875003755805 0.995009915655011 0.9904126365956704 1.0 12.112520241642558 -6.459153700572575 24.99998198527529 0.9921206253988092 1.1231962776071367 0.5548619104711892 0.05938339270425983 175.41079617169095 68815.16051381777 0.019312540746798158 0.021898346106672562 3.4741318715257396e-07 6.459153700572575 0.1310756522083275 IASLEVENQSLR ddPTM_A459_Selumetinib_30min_R1 1 IASLEVENQSLR 12 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;P29692-3;E9PL71;E9PPR1;E9PMW7;E9PIZ1;H0YCK7;E9PN91 P29692 EEF1D Elongation factor 1-delta 0 131.12 0.028687 3429100.0 730.85 790.77 1048.2 820.32 912.46 893.18 827.46 819.82 451.08 773.04 False True 747.8773830134551 698.1862807810003 905.8601973504583 677.0665113135211 829.9281541078974 884.1954201425532 765.0440260081318 798.0757104493379 765.4498144203039 872.2672140472546 0.8573948108669132 0.8004270589759624 1.0385122617957114 0.7762145594948859 0.9514609064085912 1.0136749449058766 0.877075297211258 0.9149440648426144 0.8775405083365154 1.0 9.768626353820116 -5.210691486071251 24.99970903952242 0.9243443960898227 0.8289108691561514 0.22750122070585066 0.0745330815707977 545.5986150444619 268773.83588388434 0.01820043576380122 0.048153676491522024 6.1561403705214385e-06 5.210691486071251 -0.09543352693367124 IASLEVENQSLR ddPTM_A459_Selumetinib_30min_R2 1 IASLEVENQSLR 12 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;P29692-3;E9PL71;E9PPR1;E9PMW7;E9PIZ1;H0YCK7;E9PN91 P29692 EEF1D Elongation factor 1-delta 0 139.15 0.016366 2747100.0 9129.4 11644.0 12296.0 10101.0 10094.0 8683.0 9022.3 9100.8 7575.6 10725.0 False True 8622.024495883801 12537.057358638882 11504.888746872555 8725.226374803087 8825.901478495056 9879.004433573857 9441.854827348283 9127.281821281453 9090.931679949466 10415.34138310348 0.827819672802187 1.2037106511916549 1.1046098561432292 0.8377283138273106 0.8473943535651238 0.9485051012922431 0.9065333991515192 0.8763305479442459 0.8728404903460422 1.0 13.346422506843403 -5.758845359454318 24.99996155371232 0.8936149962898522 1.0612131390431627 0.31368292614815907 0.09856416240259239 69.92849784485001 673921.6285777872 0.026268085196431375 0.042961051355773563 1.7424271942502288e-06 5.758845359454318 0.16759814275331053 IASPVS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 IASPVSR 7 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 1 IAS(0.453)PVS(0.547)R 94.409 0.024453 23362000.0 1285.9 1581.9 1931.7 2006.0 1559.0 1394.2 1446.3 1369.6 589.02 1271.7 True False 1315.8589680741638 1396.690412594642 1669.3857500685733 1655.6897572836504 1417.988725263806 1380.1756138323158 1337.2044265771904 1333.2737589122155 999.5239196813145 1434.935082406981 0.91701637531011 0.9733474564241702 1.1633876476616078 1.1538429700292587 0.9881901576238912 0.9618383652012947 0.9318919322358082 0.9291526670849545 0.696563859881869 1.0 10.486769754379758 -7.179905872699554 1.3340543358698609 0.8634151133492607 1.049991335353838 0.34047529359214745 0.10051097830231566 0.5055629474495308 1.7766449227546193 0.0624071505591806 0.03888690660582029 6.608366596602754e-08 7.179905872699554 0.18657622200457724 IATS(ph)LDGFDVASVQQQR ddPTM_A459_Selumetinib_30min_R2 1 IATSLDGFDVASVQQQR 17 0 O60664-3;O60664;K7ERZ3;O60664-4;O60664-2 O60664-3 PLIN3 Perilipin-3 1 IAT(0.289)S(0.711)LDGFDVASVQQQR 137.79 0.00043011 0.0 10817.0 10365.0 8162.4 13142.0 8871.0 7874.9 7433.0 7354.5 5601.3 9835.2 True False 10215.834443881868 11159.962171272073 7637.2400705491655 11352.036928785494 7756.545672253785 8959.59599377528 7778.649228210083 7375.900377396978 6721.716513398408 9551.232221081522 1.0695828776242537 1.1684316654598508 0.7996078300444015 1.1885416107598377 0.8120989514979546 0.9380565550484282 0.8144131613762896 0.7722459476083995 0.7037538568648981 1.0 13.221471154414173 -6.436555180156111 0.9187115831041327 0.8034266137209494 1.0696834989725257 0.34793444458876954 0.1322850677610533 0.6029993810169935 1.1060529303260704 0.06685138481857057 0.0879370342820107 3.65969438623161e-07 6.436555180156111 0.2662568852515763 IAVAAQNCYK ddPTM_A459_Selumetinib_30min_R2 2 IAVAAQNCYK 10 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 ; 186.13 0.0026375 14201700.0 91380.0 76585.0 93651.0 96302.0 99957.0 77851.0 83347.0 82939.0 65214.0 85116.0 False True 86301.4654231234 82458.82324041206 87625.59661949908 83185.50146978407 87399.50803308205 88574.26858898514 87222.80064894733 83180.33875870942 78258.6222314042 82658.47992207341 1.0440727376608476 0.9975845589968558 1.06009204018884 1.0063758920827905 1.0573568267342717 1.07156904739222 1.0552190256967822 1.0063134337472452 0.9467706435586863 1.0 16.3348752125451 -7.988185857750821 4.819841925920679 0.973512713225743 1.0408523476536755 0.5470268462782895 0.025105454997172438 0.13600543395088124 8.541126612037866 0.015847015296414576 0.006696495807987137 1.0275764492972467e-08 7.988185857750821 0.06733963442793256 IAVETAAT(ph)ARK ddPTM_A459_Selumetinib_30min_R1 2 IAVETAATARK 11 1 P43250-2 P43250-2 1 IAVET(0.001)AAT(0.999)ARK;IAVET(0.001)AAT(0.999)ARK 70.563 0.036595 7123300.0 5517.3 5999.1 6000.8 5969.7 5750.700000000001 5838.700000000001 4766.4 5785.6 5587.0 5415.8 True False 5645.842355203032 5296.7225830940715 5185.924320034945 4927.20396014766 5230.550200368548 5779.967979115438 4406.866610549345 5632.147093722632 9480.730941664979 6110.970684359312 0.9238863425827339 0.866756339815332 0.8486252983193043 0.8062882665692642 0.8559278829066957 0.9458346762992895 0.7211401982059042 0.9216452482970992 1.5514279860530797 1.0 12.577185844785246 -8.099458852057136 7.345968325228982 1.2714891346956685 0.8526403126398735 0.6001840967399341 0.13627164717811552 0.16035638463285415 10.335018589758239 0.08394625219864904 0.031435854530018355 7.953186157301977e-09 8.099458852057136 -0.418848822055795 IAVHCTVR ddPTM_A459_Selumetinib_30min_R2 1 IAVHCTVR 8 0 P62913;Q5VVC8;P62913-2 P62913 RPL11 60S ribosomal protein L11 0 122.18 0.0091774 4433500.0 23524.0 18482.0 30193.0 49006.0 53862.0 33411.0 28572.0 33655.0 32274.0 31008.0 False True 22216.630254033193 19899.509971003434 28250.415251652797 42331.298259934665 47095.37402761053 38013.0619751395 29900.654614343926 33752.93047811483 38729.70181090465 30112.71847154056 0.7377822854163786 0.6608340588648747 0.9381555929051102 1.4057614326631402 1.563969525770987 1.2623590265045492 0.9929576648020983 1.1208861966419479 1.2861576030575907 1.0 14.878085334984213 -5.543188922941613 4.31940457258866 1.2420748813704836 0.713695032575167 0.6309349575663457 0.16546429993200568 0.1335931171966457 5.908883093919039 0.05024884498376992 0.09635841560179771 2.8629322915183537e-06 5.543188922941613 -0.5283798487953166 ICDQISDAVLDAHLQQDPDAK ddPTM_A459_Selumetinib_30min_R2 2 ICDQISDAVLDAHLQQDPDAK 21 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 ; 177.08 6.2042e-14 2192500.0 21680.9 19913.6 21163.0 26178.0 23051.0 19195.0 27010.0 23322.0 20838.1 18099.0 False True 20475.962373519305 21440.909087683893 19801.395620532196 22612.511240431162 20155.127301445373 21838.937015138785 28266.01851929963 23389.863158835058 25006.302265161165 17576.434843150568 1.1649667612484376 1.2198667863545312 1.126587718000655 1.2865243402442972 1.14671305536684 1.2425123302891705 1.6081770149374024 1.3307512796288121 1.4227175470061821 1.0 14.101354847316797 -7.017312652434246 24.812860233741418 1.376169874081087 1.1928089890943179 0.17524170916698933 0.14709201035230243 901.4495763914534 1291974.797772414 0.05147853840570018 0.040822769465803085 9.60920254336206e-08 7.017312652434246 -0.18336088498676917 ICDQWDALGS(ph)LTHSR ddPTM_A459_Selumetinib_30min_R1 2 ICDQWDALGSLTHSR 15 0 O43707;O43707-2;F5GXS2;O43707-3 O43707 ACTN4 Alpha-actinin-4 1 ICDQWDALGS(0.909)LT(0.088)HS(0.003)R;ICDQWDALGS(0.988)LT(0.012)HSR 134.58 0.00029003 3307200.0 2981.3 3896.1 3518.7 3888.0 4090.2 3255.1 3735.8999999999996 4378.6 1669.73 2995.5 True False 3050.7584894000324 3439.94280075225 3040.879866835581 3209.033786799016 3720.2421321834604 3222.3566493943267 3454.0980552096544 4262.4653043027365 2833.4098577458853 3380.0016036408833 0.9025908408190708 1.0177340735716809 0.8996681728079639 0.9494178296667956 1.100662830507558 0.9533595031207251 1.0219220166904524 1.261083811235852 0.8382865424364834 1.0 11.722808215655997 -6.164892226209318 8.627643661518455 1.0380389459807335 0.9441763749507729 0.13653712811272423 0.10563290959737529 0.6546198287682076 53.55981928483623 0.030032383797793497 0.03883301531407333 6.840813867097281e-07 6.164892226209318 -0.09386257102996065 ICDQWDALGSLT(ph)HSR ddPTM_A459_Selumetinib_30min_R2 1 ICDQWDALGSLTHSR 15 0 O43707;O43707-2;F5GXS2;O43707-3 O43707 ACTN4 Alpha-actinin-4 1 ICDQWDALGS(0.063)LT(0.469)HS(0.469)R 83.39299999999999 0.031954 2307100.0 9119.9 7769.7 7386.7 8847.0 10832.0 8233.4 8802.5 9974.7 7806.0 10094.0 True False 8613.052467852296 8365.611006476862 6911.447764030863 7642.023338073748 9471.18732069135 9367.4761146363 9211.83369182285 10003.724725599526 9367.418117863348 9802.559992638366 0.8786533797620847 0.8534108449996083 0.7050655919699852 0.7795946511740647 0.9661952926382624 0.955615280260584 0.9397375480222365 1.0205216528245922 0.9556093637680559 1.0 13.258942850867559 -6.267050537689408 23.99715152897305 0.9714456088398421 0.8006178415252903 0.7463684444508856 0.04817366409498289 140.72005015975043 601814.6260913875 0.01585366862267975 0.018498298587334913 5.406914004698216e-07 6.267050537689408 -0.17082776731455185 ICNGGLS(ph)PGNPGDSK ddPTM_A459_Selumetinib_30min_R1 1 ICNGGLSPGNPGDSK 15 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 ICNGGLS(0.995)PGNPGDS(0.005)K 163.34 9.9676e-06 0.0 2188.3 2302.8 2129.7 1943.1 1841.7 1699.8 2123.7 2345.5 1129.3 1937.4 True False 2239.283132309427 2033.187105457323 1840.498437604722 1603.7740615044158 1675.1185601785432 1682.7015552949151 1963.5075991993203 2283.2897207422616 1916.3396191913814 2186.084161874095 1.024335280115531 0.9300589341054025 0.8419156360507604 0.7336286907314337 0.7662644418696537 0.7697331990422371 0.8981848153165506 1.0444656068432578 0.8766083450092489 1.0 11.094133228938643 -7.52690468147399 21.859658714756545 0.9705874173751704 0.8390664128718002 0.2970596570111552 0.0888773299992963 33.73901394189856 183166.66903604145 0.04525518460678366 0.026348431514661656 2.972318321657108e-08 7.52690468147399 -0.13152100450337023 ICNGGLS(ph)PGNPGDSK ddPTM_A459_Selumetinib_30min_R2 1 ICNGGLSPGNPGDSK 15 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 ICNGGLS(0.998)PGNPGDS(0.002)K 72.428 0.046027 31602000.0 30486.0 23648.0 34399.0 28621.0 36009.0 26392.0 28372.0 26054.0 20687.0 23643.0 True False 28791.710165127362 25461.725559695326 32185.80579079938 24722.770426021114 31485.227495455572 30027.258437277585 29691.354218051427 26129.812826528127 24824.978043074436 22960.36515810868 1.2539744018382601 1.1089425357289349 1.4017985153617054 1.0767585905440193 1.3712860086781438 1.307786624058684 1.2931568820265749 1.1380399504360723 1.0812100710126227 1.0 14.486857966145077 -8.128785075848636 2.0210069332625133 1.0197349935676672 1.257540992074777 0.44982923741802805 0.09800795998210916 0.30435317243344034 2.212112842105879 0.08484532448211385 0.026215655591855062 7.433869350603817e-09 8.128785075848636 0.23780599850710993 ICRDPQT(ph)PVLQTK ddPTM_A459_Selumetinib_30min_R1 1 ICRDPQTPVLQTK 13 1 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 ICRDPQT(0.99)PVLQT(0.01)K 156.2 0.0037859 22886000.0 1400.1 1606.4 1893.7 1904.5 1668.5 1405.1 1545.7 1246.4 872.16 1268.8 True False 1432.7196058796444 1418.3219412049013 1636.5459413495155 1571.914826892676 1517.5844695976 1390.9659697287248 1429.1066045497905 1213.341423122215 1479.9918199539147 1431.6628391585893 1.0007381393804118 0.9906815364701869 1.1431084865703012 1.097964397690531 1.060015269020678 0.9715737055424427 0.9982144995742844 0.8475050060217494 1.0337572363222958 1.0 10.483476058307485 -6.786850342770037 4.43327185918122 0.9609216296557244 1.0622360407839502 0.33543152589967484 0.06149893047783881 0.22774450774506444 10.33677325185978 0.02248006443688034 0.020583022496799427 1.6336147921291324e-07 6.786850342770037 0.10131441112822581 ICS(ph)DEEEDEEKGGR ddPTM_A459_Selumetinib_30min_R2 1 ICSDEEEDEEKGGR 14 1 Q9NPG3;Q9NPG3-2 Q9NPG3 UBN1 Ubinuclein-1 1 ICS(1)DEEEDEEKGGR 78.244 0.021172 3873500.0 14191.0 12707.0 15619.0 13011.0 14026.0 12096.0 13340.0 11623.0 11565.0 12042.0 True False 13402.32103107402 13681.586040555156 14614.090544681394 11238.87935477309 12263.928485969063 13762.11420344458 13960.336432708518 11656.82100570877 13878.323153098845 11694.316171126533 1.1460542741408497 1.169934679407354 1.2496746565450174 0.9610548569331548 1.0487084756823073 1.1768207736185101 1.1937710789089855 0.9967937274083338 1.1867579899511065 1.0 13.513519881652906 -14.522878745280336 0.12968296856731049 0.620204899846377 1.1709363425630495 0.14652762532834573 0.08887328581412154 307.9287675614632 2.512221092384418 30.92765438112154 0.7062831050943359 3.0000000000000132e-15 14.522878745280336 0.5507314427166725 ICT(ph)LPEK ddPTM_A459_Selumetinib_30min_R1 2 ICTLPEK 7 0 Q658Y4;E7ER68;G3V120 Q658Y4 FAM91A1 Protein FAM91A1 1 ICT(1)LPEK;ICT(1)LPEK 125.86 0.013804 94925000.0 10979.400000000001 11977.8 12785.3 13387.5 12263.9 10919.6 11176.9 11951.7 6081.7 9137.2 True False 11235.198657806566 10575.433607671845 11049.126484625844 11049.624439498928 11154.632410367398 10809.758738203529 10333.81743442619 11634.702091407069 10320.200710206522 10310.048623864972 1.0897328487666025 1.0257404201947775 1.0716851964257574 1.0717334944397874 1.0819185066254142 1.048468259711391 1.0023054023728073 1.1284817866402572 1.0009846788033618 1.0 13.331763516255805 -8.45122661289285 24.999973437101236 0.9999972129526205 1.0622349234315305 0.3787246151261232 0.032900872401573675 132.30787850910568 46162.68816207242 0.03013443592631931 0.007780677900550976 3.5381267505797265e-09 8.45122661289285 0.062237710478910024 ICT(ph)LPEK ddPTM_A459_Selumetinib_30min_R2 1 ICTLPEK 7 0 Q658Y4;E7ER68;G3V120 Q658Y4 FAM91A1 Protein FAM91A1 1 ICT(1)LPEK 108.98 0.037504 4263000.0 21130.0 18564.0 20762.0 16586.0 17033.0 16044.0 16758.0 19407.0 12524.0 16056.0 True False 19955.679190091876 19987.799107331866 19426.195523956398 14326.95818755411 14893.162263047983 18253.91536706887 17537.280205347044 19463.47115699819 15029.149949797666 15592.421561502046 1.2798319434463463 1.2818919132280313 1.2458741862085108 0.9188411261870711 0.9551538998804043 1.1706914987559147 1.1247310198851272 1.2482648112243084 0.9638752961185255 1.0 13.92855738093175 -5.613148873620733 8.50387218577797 1.0686968170097666 1.2766043879517412 0.4979766093892416 0.0984446369924011 0.2355029247005341 19.581495167109 0.02849808791226735 0.04946394832259599 2.4369752942232543e-06 5.613148873620733 0.20790757094197465 ICTEQSNS(ph)PPPIR ddPTM_A459_Selumetinib_30min_R1 4 ICTEQSNSPPPIR 13 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 ICTEQSNS(1)PPPIR;ICTEQS(0.035)NS(0.965)PPPIR;ICTEQS(0.011)NS(0.989)PPPIR;ICTEQS(0.007)NS(0.993)PPPIR 162.88 0.0003632 56123000.0 7740.75 8068.08 7519.1900000000005 9138.3 8512.09 7061.780000000001 7499.95 6884.91 4441.610000000001 6117.539999999999 True False 7921.094414122467 7123.465442851363 6498.125297954196 7542.467452136177 7742.17296243155 6990.744904783229 6934.222733255616 6702.299821460501 7537.087767640696 6902.785848885748 1.147521390280577 1.0319696422280342 0.9413772120720111 1.0926700635445161 1.1216012102825552 1.0127425445063865 1.004554231444822 0.9709557804900453 1.0918907137843972 1.0 12.752963011659578 -6.900388405547442 19.04645199465102 1.0134268946101752 1.060296353242116 0.14922717039341993 0.05964872304664914 5.701470997156019 1072.957864963719 0.0218969132082327 0.019311340105921147 1.2578000117586213e-07 6.900388405547442 0.0468694586319407 ICTEQSNS(ph)PPPIR ddPTM_A459_Selumetinib_30min_R2 4 ICTEQSNSPPPIR 13 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 ICT(0.057)EQS(0.071)NS(0.872)PPPIR;ICTEQS(0.226)NS(0.774)PPPIR;ICT(0.002)EQS(0.214)NS(0.784)PPPIR;ICTEQSNS(1)PPPIR 164.92 0.00036256 71612000.0 80260.0 86203.0 97330.0 89942.0 97536.0 64061.1 74795.3 65913.3 70515.9 78975.0 True False 75799.4705062364 92814.49291366764 91067.89376489165 77691.74444139579 85282.65569709668 72884.93503623374 78273.42965407533 66105.09679046576 84621.05037886753 76694.78654830746 0.988326246380422 1.210179949522474 1.1874065743377622 1.0129990308071382 1.1119746143811224 0.9503245046562061 1.0205834474129938 0.8619242554228688 1.1033481438215829 1.0 16.22684089109073 -6.461921454316332 1.4376361021082478 0.980517185370709 1.1249574814793823 0.2726325416227271 0.08730480115680822 0.4727840192412611 1.9922656023859246 0.034203196655903684 0.0399430627865623 3.452061670289044e-07 6.461921454316332 0.14444029610867337 ICTEQSNS(ph)PPPIRR ddPTM_A459_Selumetinib_30min_R1 2 ICTEQSNSPPPIRR 14 1 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 ICTEQS(0.035)NS(0.965)PPPIRR;ICTEQS(0.027)NS(0.973)PPPIRR 121.56 0.0034167 24851400.0 2462.7 2151.7 3107.3 3471.3 2691.0 2326.55 2332.92 2003.59 1140.75 1589.99 True False 2520.0761184199728 1899.777963701809 2685.3457271771404 2865.102619371253 2447.599525134637 2303.147019338383 2156.9459661553315 1950.4482846224641 1935.7694329164708 1794.0807043141288 1.404661514033389 1.0589144396534202 1.4967808977153787 1.596975326963662 1.3642638925044046 1.2837477231654797 1.202256933575307 1.0871574951630252 1.0789756716415437 1.0 10.809029074080337 -7.447704983096366 1.3907778877795542 1.0422783915993534 1.3815278876145702 0.5491858733959915 0.13018143105729674 0.3793802039107469 1.4062170315539912 0.09675333489647793 0.04828561803870971 3.5669335348549986e-08 7.447704983096366 0.3392494960152168 ICTGQVPS(ph)AEDEPAPK ddPTM_A459_Selumetinib_30min_R2 1 ICTGQVPSAEDEPAPK 16 0 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 ICT(0.001)GQVPS(0.999)AEDEPAPK 119.96 0.0015238 0.0 23023.0 24996.0 24599.0 25044.0 28569.0 24165.0 21297.0 23708.0 21024.0 19663.0 True False 21743.473828371294 26913.112825192162 23016.32712136613 21632.9639966903 24979.906809899487 27493.509401970787 22287.352699204897 23776.986354929326 25229.387459641173 19095.27809939056 1.1386832763155856 1.4094119334167283 1.2053412891693214 1.132895990521381 1.3081719302478625 1.4398067029381605 1.1671656512777477 1.2451762279224508 1.3212369743097057 1.0 14.220928310753136 -10.877538193625792 5.485929250897753 0.9999236107421979 1.2650482251132513 0.3759127891579319 0.10167170769329154 9.427866682060537e-05 1.1090537872446e-05 0.09770462005287439 0.023690045652132584 1.3257505207325247e-11 10.877538193625792 0.2651246143710534 ICTLPS(ph)PPSPLASLAPVADSSTR ddPTM_A459_Selumetinib_30min_R2 1 ICTLPSPPSPLASLAPVADSSTR 23 0 Q9UER7-3;Q9UER7;Q9UER7-2 Q9UER7-3 DAXX Death domain-associated protein 6 1 ICT(0.003)LPS(0.885)PPS(0.113)PLASLAPVADSSTR 85.84899999999998 0.00017655 3448000.0 40821.0 38993.0 48052.0 49409.0 43600.0 37258.0 43596.0 38560.0 35852.0 43252.0 True False 38552.33223941034 41983.63771774354 44960.38663506182 42679.40896472091 38122.57821105453 42389.95130555045 45623.30038383516 38672.20321604837 43023.40178857758 42003.202377808106 0.917842689532144 0.999534210275479 1.0704037808987656 1.0160989293347327 0.9076112308807232 1.0092076057502386 1.086186238217391 0.9206965428064688 1.024288610225312 1.0 15.358211704547012 ICTLPSPPS(ph)PLASLAPVADSSTR ddPTM_A459_Selumetinib_30min_R1 2 ICTLPSPPSPLASLAPVADSSTR 23 0 Q9UER7-3;Q9UER7;Q9UER7-2 Q9UER7-3 DAXX Death domain-associated protein 6 1 ICT(0.001)LPS(0.12)PPS(0.878)PLASLAPVADSSTR;ICTLPSPPS(0.999)PLAS(0.001)LAPVADSSTR 95.444 5.1526e-05 13856700.0 4759.7 5269.9 5151.8 5545.6 5153.6 4808.6 5214.1 5244.4 2945.7 4017.4 True False 4870.591749236016 4652.897658089954 4452.2138568117625 4577.165063804687 4687.45778994198 4760.229849859474 4820.796239104007 5105.301475787982 4998.637754584303 4533.072422789818 1.0744570778859244 1.0264335585502053 0.9821625250080844 1.0097268776896646 1.0340575558369631 1.050111140057598 1.0634721419555688 1.1262342622459125 1.1027041459681686 1.0 12.146273495337798 -7.072833847676886 1.8702788485240907 1.0851628882553288 1.0216382211160133 0.24923537861751566 0.03757764491393448 0.3995942328457034 2.778160490694165 0.017844725350999034 0.012974056908092127 8.456022936930365e-08 7.072833847676886 -0.06352466713931548 ICTLPSPPS(ph)PLASLAPVADSSTR ddPTM_A459_Selumetinib_30min_R2 1 ICTLPSPPSPLASLAPVADSSTR 23 0 Q9UER7-3;Q9UER7;Q9UER7-2 Q9UER7-3 DAXX Death domain-associated protein 6 1 ICT(0.003)LPS(0.129)PPS(0.869)PLASLAPVADSSTR 103.57 1.8637e-05 4685700.0 21797.0 18897.0 21100.0 22831.0 20227.0 16928.0 15972.0 17127.0 16070.0 19564.0 True False 20585.610000304438 20346.33913656811 19742.44897194297 19721.37841432823 17685.9034283257 19259.678342915842 16714.729647917575 17176.836734472512 19284.449033315905 18999.136486623447 1.0835024010063807 1.0709086252890059 1.039123487840769 1.0380144607210589 0.9308793292146543 1.013713352523986 0.8797625965625209 0.9040851275828274 1.0150171323256367 1.0 14.213646228906923 -6.019433846722206 1.3813345458357003 0.9481874165813237 1.0756242060377181 0.5445552905799279 0.04464428766490928 0.3101268544166744 1.199080837191662 0.015984500360336884 0.02833266761977926 9.562383415469077e-07 6.019433846722206 0.12743678945639447 IDAGTMAEPSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 4 IDAGTMAEPSASPSK 15 0 Q8IXQ3 Q8IXQ3 C9orf40 Uncharacterized protein C9orf40 1 IDAGTMAEPS(0.02)AS(0.969)PS(0.012)K;IDAGTMAEPS(0.033)AS(0.956)PS(0.011)K;IDAGTMAEPSAS(0.882)PS(0.118)K;IDAGTMAEPSAS(0.998)PS(0.001)K 156.29 0.00016464 42134600.0 315975.0 284522.0 307441.0 316574.0 305710.0 253729.0 280222.0 253559.0 210322.0 291398.0 True False 298414.3744481439 306343.92251757573 287660.5807764519 273456.0750793895 267303.9767179241 288677.86662746326 293252.878249359 254296.81471104795 252392.27688768262 282984.5825970714 1.0545252031381591 1.0825463341717263 1.016523861959075 0.9663285277585276 0.9445884799262221 1.0201187074509224 1.036285707009375 0.898624272662689 0.8918940903824865 1.0 18.110363929555305 -5.537936305810289 2.8771645109902972 0.9654490483199286 1.0681342195045616 0.4613791429384936 0.04474136906216394 0.2531202374848379 4.228216357663396 0.013753641237120638 0.029503227792198803 2.897768547016284e-06 5.537936305810289 0.10268517118463294 IDASKNEEDEGHS(ph)NS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 2 IDASKNEEDEGHS(0.999)NS(0.847)S(0.154)PR 81.226 0.02193 0.0 2562.5 2385.6 3788.2 3468.0 2707.0 2639.9 2719.6 2160.6 1547.4 1814.6 True False 2622.2012642429763 2106.2928429646477 3273.783247093114 2862.3789024225784 2462.152327959667 2613.345002837422 2514.458382437478 2103.2938693821056 2625.8247823755833 2047.5215857008004 1.2806708767104311 1.0287036081447374 1.5989004804423605 1.3979725158515868 1.2025037221363173 1.2763455199144864 1.2280497553713752 1.0272389234237138 1.2824405860790222 1.0 10.999662946012789 -7.38395259294167 1.2419420992611527 1.1062455162448157 1.3113723373649542 0.23726199286255656 0.15302501073881022 0.7643486829581447 2.2554835709198557 0.10973205477426408 0.05677067536617401 4.1309259221491436e-08 7.38395259294167 0.20512682112013847 IDASKNEEDEGHS(ph)NSSPR ddPTM_A459_Selumetinib_30min_R1 1 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 IDASKNEEDEGHS(0.98)NS(0.016)S(0.003)PR 114.58 0.0051479 28812000.0 1480.5 1332.2 2875.6 2815.9 2619.3 1811.4 2035.2 1625.9 985.26 1363.5 True False 1514.9927694484782 1176.2254046770222 2485.1093145401414 2324.155925989546 2382.384777474975 1793.1789606196085 1881.6832254510798 1582.7758503324842 1671.914259456745 1538.518506614705 0.9847088370630055 0.7645182034664905 1.61526124245868 1.5106454137516527 1.5484927657562468 1.1655231658962935 1.2230488079025197 1.028766208224015 1.0867040287578722 1.0 10.587326082406133 -7.605545475413289 2.0180349776493656 1.0355266884505456 1.2827208567604504 0.14201830122345782 0.24676755700217387 0.754089986699865 6.088882726617054 0.1747834740150558 0.08324153230939368 2.480016239094462e-08 7.605545475413289 0.24719416830990482 IDASKNEEDEGHSNS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 2 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 IDASKNEEDEGHS(0.323)NS(0.404)S(0.273)PR;IDASKNEEDEGHS(0.005)NS(0.498)S(0.498)PR 91.789 0.0028797 699939000.0 12541.599999999999 13691.7 22041.6 21890.6 16739.0 16946.8 13546.2 14588.7 10380.3 10941.6 True False 12833.79487829452 12088.669398901358 19048.471785842255 18067.817647454365 15224.960405510485 16776.33057846327 12524.399227891816 14201.76028522389 17614.610952884366 12346.060940209352 1.0395052268450002 0.9791519301132148 1.5428784839222776 1.463447955988138 1.2331836428836156 1.3588407395451259 1.014444954430902 1.150306997025326 1.4267393493511846 1.0 13.591763197189428 -7.240083276112332 24.89042794809754 1.1603983668300302 1.2758948080546209 0.08409836537417126 0.19420775476360574 2365.921365073033 2757473.430907741 0.07935018939238792 0.061409212096242206 5.7532960711474784e-08 7.240083276112332 0.11549644122459068 IDASKNEEDEGHSNS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 5 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 IDASKNEEDEGHS(0.077)NS(0.566)S(0.357)PR;IDASKNEEDEGHS(0.095)NS(0.452)S(0.452)PR;IDASKNEEDEGHS(0.016)NS(0.582)S(0.401)PR;IDASKNEEDEGHS(0.16)NS(0.42)S(0.42)PR;IDASKNEEDEGHS(0.13)NS(0.435)S(0.435)PR 99.569 0.0016484000000000002 1075406000.0 426825.0 531641.0 521469.0 545816.0 483229.0 262682.0 220758.6 245345.9 178101.0 460977.0 True False 403103.77521585295 572416.1552047511 487918.25227251876 471474.9192148827 422521.4528979281 298864.0611102209 231024.31232486732 246059.81594979964 213726.17655772265 447667.3962479151 0.9004537265711816 1.2786639366690689 1.0899124134613392 1.053181275130841 0.9438289597126225 0.6676029204161923 0.5160624031617609 0.5496487303121209 0.47742180544987145 1.0 18.772067724587416 -6.662431481866957 2.177786408795733 0.5942120461413608 1.0962870384785224 0.6231600374983648 0.1612742764555898 0.1781039436590522 1.728882357948293 0.05816821648431848 0.057175452611447436 2.1755472404917074e-07 6.662431481866957 0.5020749923371616 IDASKNEEDEGHSNSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 IDASKNEEDEGHS(0.001)NS(0.256)S(0.744)PR;IDASKNEEDEGHS(0.001)NS(0.219)S(0.781)PR;IDASKNEEDEGHS(0.055)NS(0.202)S(0.742)PR;IDASKNEEDEGHS(0.077)NS(0.306)S(0.617)PR;IDASKNEEDEGHS(0.029)NS(0.238)S(0.733)PR;IDASKNEEDEGHS(0.001)NS(0.252)S(0.747)PR;IDASKNEEDEGHS(0.024)NS(0.272)S(0.703)PR 185.96 8.588700000000002e-10 606858400.0 13032.880000000001 13771.69 19621.8 21451.800000000003 17070.699999999997 14920.999999999998 13381.16 13363.990000000003 8012.290000000001 9682.349999999999 True False 13336.520746430042 12159.29413251501 16957.267334832286 17705.645830158217 15526.658199076861 14770.908287184035 12371.808327966273 13009.533572842634 13596.270935491832 10925.17393657564 1.2207147294727838 1.1129611485459048 1.5521279050818784 1.6206282785926822 1.4211817852250597 1.352006693251219 1.1324129391247078 1.1907850299104996 1.2444901119582004 1.0 13.415368628194091 -7.1878568506809115 4.406811784190929 1.1574659051325553 1.3917952583371205 0.3799855041649991 0.14852514489916116 0.28684340060893887 10.6162745078645 0.06593048253749167 0.049741394844324834 6.488482674457828e-08 7.1878568506809115 0.23432935320456516 IDASKNEEDEGHSNSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 IDASKNEEDEGHS(0.003)NS(0.208)S(0.789)PR 90.765 0.0030923 68610000.0 46684.0 56237.0 63924.0 60128.0 57342.0 33781.0 25094.0 31661.0 21824.0 53230.0 True False 44089.49017085894 60550.19706954438 59811.199435188755 51938.462673414506 50138.18531601586 38434.02611661387 26260.92072281766 31753.128268239303 26189.409813508806 51693.11159185067 0.8529084207383943 1.1713397627835973 1.157043899919112 1.0047463012770645 0.9699200487656474 0.7435038234895679 0.50801586350932 0.6142622738393084 0.506632489456052 1.0 15.657684425381982 -6.769890785166543 2.385288095216915 0.6234071148041245 1.0592715994469308 0.574664567575178 0.1543414151774023 0.18586389810002615 2.169568354119176 0.056997942138806885 0.05240048784465639 1.6986707744456832e-07 6.769890785166543 0.43586448464280636 IDASKNEEDEGHSNSSPR ddPTM_A459_Selumetinib_30min_R1 2 IDASKNEEDEGHSNSSPR 18 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 ; 106.82 0.0013012 22098700.0 7459.7 7505.6 11105.3 12081.3 11308.7 9828.400000000001 9365.7 7641.2 3851.9 5161.3 False True 7633.496495950563 6626.840862741227 9597.2612570464 9971.52774908821 10285.83008171315 9729.535219473206 8659.237708631668 7438.530553884365 6536.3929683549895 5823.803130319377 1.3107408209267444 1.137888887115903 1.64793710266097 1.7122020655497971 1.7661706365319867 1.6706497458370713 1.4868699224310484 1.2772633942858638 1.1223581604820723 1.0 12.507745871704108 -8.022668735720105 1.8301129598372727 1.0335912272228656 1.5475339349269488 0.5304563451024384 0.18141144762174144 0.3302837674300771 1.9911615689519457 0.18214913919392792 0.05976949739911154 9.491421589138876e-09 8.022668735720105 0.5139427077040832 IDDIVSGHK ddPTM_A459_Selumetinib_30min_R2 1 IDDIVSGHK 9 0 B4DUR8;P49368-2;P49368 B4DUR8 CCT3 T-complex protein 1 subunit gamma 0 98.048 0.028167 2645200.0 29030.0 30325.0 35018.0 35663.0 44619.0 32366.0 25308.0 27992.0 27298.0 39125.0 False True 27416.62881629756 32650.829989756458 32764.980004715595 30805.637877893525 39013.56232107898 36824.122710705 26484.87214685064 28073.452085674944 32758.362769848027 37995.35959104182 0.7215783482876048 0.8593373070077366 0.8623416216447812 0.8107736894575036 1.026798081160343 0.9691742125105992 0.6970554412938097 0.7388652821776118 0.8621674626175002 1.0 15.213535611163838 -12.094254823683444 1.9396074545584285 3.034789142592687 0.8414299811704427 0.19160237817725545 0.09926513796680583 5431024.6745679695 204514.94442849807 48829063.08983406 0.02672729812624416 8.049060214199953e-13 12.094254823683444 -2.1933591614222445 IDDPTDSKPEDWDKPEHIPDPDAK ddPTM_A459_Selumetinib_30min_R2 1 IDDPTDSKPEDWDKPEHIPDPDAK 24 2 P27797;K7EJB9;K7EL50 P27797 CALR Calreticulin 0 43.463 0.040853 4322700.0 60646.0 51679.0 50581.0 47675.0 48223.0 40145.0 50619.0 49538.0 35575.0 46733.0 False True 57275.53810517331 55642.61312582435 47326.67352842879 41181.582756037744 42164.79562091015 45674.60934997379 52972.88379964564 49682.147378542606 42690.99404855094 45383.69686308392 1.2620289236896096 1.226048492560888 1.0428122167131195 0.9074091711893073 0.9290736219245265 1.0064100658826343 1.167222757534654 1.0947135383974227 0.9406680592227541 1.0 15.469886512332426 -5.263852076904324 3.8795307795811826 1.0114158151262032 1.2524555520175176 0.6190978023554687 0.07366542183357626 0.1549974783329971 5.412760926932473 0.022028117732278567 0.05789671069370306 5.446881450369578e-06 5.263852076904324 0.24103973689131442 IDDRDS(ph)DEEGASDR ddPTM_A459_Selumetinib_30min_R1 2 IDDRDSDEEGASDR 14 1 Q8TDD1-2;Q8TDD1 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 IDDRDS(1)DEEGASDR;IDDRDS(1)DEEGASDR 200.33 0.00033938 6701000.0 1347.4699999999998 1253.53 1502.62 1448.13 1483.07 1268.18 1452.5900000000001 1213.07 690.01 1029.26 True False 1378.863429279798 1106.7661248497125 1298.5724573008447 1195.2412802667857 1348.9265803572748 1255.4232606153116 1343.019966813082 1180.8954429933121 1170.8965736635494 1161.3755468414015 1.187267488996044 0.9529786707321241 1.1181331145059652 1.0291600193559172 1.1614904274727986 1.0809795884110804 1.1564045501609705 1.016807565997923 1.00819806035011 1.0 10.181618847698536 -7.89978740108924 8.9225587948754 1.0069353874139009 1.0923137161529473 0.28446477566393735 0.06493188812269833 0.3560166040061703 28.24256377532339 0.03385940247432924 0.01622522436300476 1.2595418407453666e-08 7.89978740108924 0.08537832873904638 IDEDGENTQIEDTEPMS(ph)PVLNSK ddPTM_A459_Selumetinib_30min_R1 7 IDEDGENTQIEDTEPMSPVLNSK 23 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 IDEDGENTQIEDTEPMS(0.996)PVLNS(0.004)K;IDEDGENTQIEDTEPMS(0.999)PVLNS(0.001)K;IDEDGENTQIEDTEPMS(1)PVLNSK;IDEDGENT(0.002)QIEDT(0.097)EPMS(0.844)PVLNS(0.056)K;IDEDGENTQIEDT(0.001)EPMS(0.997)PVLNS(0.002)K;IDEDGENTQIEDTEPMS(1)PVLNSK;IDEDGENTQIEDTEPMS(1)PVLNSK 235.74 2.4944e-32 183143800.0 23424.39 25625.3 25233.260000000002 26800.31 25727.0 22894.629999999997 25703.98 23892.41 13760.739999999998 21470.71 True False 23970.132711071426 22625.077963121228 21806.721888375698 22120.1389626254 23399.99739247076 22664.33080886082 23765.10809420699 23258.705673314686 23350.970735315343 24226.68477092585 0.9894103521682707 0.9338907975668759 0.9001116782823574 0.9130485318887506 0.965876991166072 0.9355110293943316 0.9809475922486599 0.9600449212608394 0.9638533276884239 1.0 14.564309376506342 -7.112781550410396 1.2389605587937316 0.9753413529184554 0.9342540331538893 0.303112025775253 0.025995924953758593 0.6274870221621993 1.9284998937168136 0.016239254160041246 0.010610905936496516 7.712913300987064e-08 7.112781550410396 -0.04108731976456603 IDEDGENTQIEDTEPMS(ph)PVLNSK ddPTM_A459_Selumetinib_30min_R2 3 IDEDGENTQIEDTEPMSPVLNSK 23 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 IDEDGENTQIEDTEPMS(1)PVLNSK;IDEDGENTQIEDTEPMS(0.999)PVLNS(0.001)K;IDEDGENTQIEDTEPMS(0.997)PVLNS(0.003)K 172.67 7.442e-13 36682800.0 176783.0 158310.0 174343.0 192990.0 187292.0 127543.0 151643.0 156325.0 119134.0 160516.0 True False 166958.10857841972 170451.86795311948 163125.9611903062 166704.42907368063 163762.70454827597 145110.89052992174 158694.69997490384 156779.879869003 142964.12888208206 155881.48600934618 1.071057973930332 1.0934708945672977 1.0464742501911077 1.0694305869247713 1.050559041619973 0.9309052296385046 1.0180471333548167 1.0057633134162125 0.9171334745520091 1.0 17.25009006425178 -6.618996120820244 6.399885468765847 0.9777581505028016 1.0688602123866182 0.6822593184582444 0.03148981367303949 0.12913637218059235 7.2576262880590745 0.01032480362261895 0.010312197842905156 2.4043842762115463e-07 6.618996120820244 0.09110206188381664 IDENS(ph)DKEMEVEESPEK ddPTM_A459_Selumetinib_30min_R1 2 IDENSDKEMEVEESPEK 17 1 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 IDENS(1)DKEMEVEESPEK;IDENS(1)DKEMEVEESPEK 113.63 0.0009882 24259000.0 5307.9 6368.6 3900.0 4319.0 3530.2999999999997 4918.6 5109.8 5560.9 3475.5 6283.0 True False 5431.563742624506 5622.961351318188 3370.401421166555 3564.7677276710256 3210.9849883250863 4869.123349731483 4724.363672076419 5413.406867651094 5897.669659523286 7089.484251602635 0.7661437066309382 0.7931411019140175 0.47540854899348267 0.5028246909308222 0.4529222259855105 0.6868092483075591 0.666390319014876 0.7635826070743228 0.8318898032942341 1.0 12.791464962236974 -8.234301654820717 1.0108030047287517 0.9906555778654094 0.6026499696210519 0.5667346119559147 0.10931113466978426 0.407273482735612 0.8472730145483335 0.11470188594280607 0.03976759682057339 5.830399922435732e-09 8.234301654820717 -0.3880056082443575 IDENS(ph)DKEMEVEESPEK ddPTM_A459_Selumetinib_30min_R2 1 IDENSDKEMEVEESPEK 17 1 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 IDENS(1)DKEMEVEESPEK 78.057 0.010563 31597000.0 65787.0 38460.0 44442.0 46284.0 36384.0 30603.0 49641.0 55193.0 33962.0 37955.0 True False 62130.821906226876 41409.75833160868 41582.65010479099 39980.03935564659 31813.116642913057 34818.28546362555 51949.404861775394 55353.60249230701 40755.34897756532 36859.14053106689 1.6856286123616917 1.1234596828622816 1.1281502906922876 1.0846709602995013 0.8630997951810414 0.9446309643134191 1.4094035865537777 1.5017605319812593 1.1057053526035012 1.0 15.169734810636799 -4.760516198253946 24.89308097702649 1.1379487053262938 1.6856292808139421 0.44838750254911797 0.1849795733073506 23.222597895711736 625828.1894177073 0.05140548600743177 0.30318737654675915 1.7357365224096615e-05 4.760516198253946 0.5476805754876484 IDEPLEGSEDR ddPTM_A459_Selumetinib_30min_R1 2 IDEPLEGSEDR 11 0 P61978;P61978-2;P61978-3;S4R359 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 204.79 0.00024373 80535000.0 3774.0 3699.3 3522.3 3653.4 3726.2 3188.2 3686.9 3353.1 2004.1999999999998 2965.7 False True 3861.92685707434 3266.184236242089 3043.9910066089665 3015.4022728116056 3389.16586791404 3156.1296026539862 3408.7941646597787 3264.164895596197 3400.981019023616 3346.3764833643036 1.154062274903308 0.9760360953046165 0.9096379387499963 0.901094747647775 1.0127867813924862 0.9431483929987904 1.018652318890528 0.9754326543421514 1.0163175111738818 1.0 11.708384049263692 -7.289363472470718 24.413183323470218 1.0005533345408821 0.9768115405399648 0.015430973049310293 0.06730424519237052 2913.086091807278 2546807.8248922452 0.0292151739940994 0.019703916514783405 5.136136149143737e-08 7.289363472470718 -0.02374179400091736 IDEPLEGSEDR ddPTM_A459_Selumetinib_30min_R2 2 IDEPLEGSEDR 11 0 P61978;P61978-2;P61978-3;S4R359 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 162.64 0.008696299999999999 103056000.0 52276.0 53608.0 51991.0 61704.0 68115.0 44140.0 45109.0 51069.0 41652.0 56122.0 False True 49370.70919740856 57719.56122311177 48645.95566352074 53299.808754662896 59557.78474417387 50219.88433697452 47206.657881787774 51217.60233507194 49983.56385411784 54501.61203753225 0.9058577783609352 1.0590431927658122 0.8925599417136681 0.9779492158499506 1.0927710670862307 0.9214385127249238 0.8661515892278407 0.9397447235102185 0.9171024853301022 1.0 15.734011281808902 IDFDSVSSIMAS(ph)SQ ddPTM_A459_Selumetinib_30min_R2 1 IDFDSVSSIMASSQ 14 0 K7EK53;A0A087WVB9;K7ERF1;Q9UBQ5 K7EK53 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 IDFDSVSSIMAS(0.523)S(0.477)Q 150.61 0.00041771 8448000.0 5689.3 6745.1 7621.7 8496.7 8953.9 6740.4 5882.7 4390.5 4241.6 6618.3 True False 5373.111482072398 7262.427481085121 7131.328119879515 7339.434802374952 7829.0310331183755 7668.828916740894 6156.25720634891 4403.275628113599 5090.038520206148 6427.212482591494 0.835994063775829 1.1299498033954625 1.1095522575603594 1.1419312528182737 1.2181067693535563 1.1931811710772586 0.9578424897299593 0.685098810727068 0.791951181634781 1.0 12.649977453086683 -7.518426341265515 5.267766313095135 0.8044850544454375 1.1112085877620548 0.5136956113774704 0.12171603485184508 0.12753255333351424 11.310890939616181 0.056335140768803554 0.034183688757433585 3.0309143139469255e-08 7.518426341265515 0.3067235333166173 IDFDSVSSIMASS(ph)Q ddPTM_A459_Selumetinib_30min_R1 2 IDFDSVSSIMASSQ 14 0 K7EK53;A0A087WVB9;K7ERF1;Q9UBQ5 K7EK53 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 IDFDSVSSIMAS(0.011)S(0.989)Q;IDFDSVSSIMAS(0.03)S(0.97)Q 187.97 9.0601e-05 28901000.0 4864.1 5761.6 5897.1 5942.9 5218.6 5157.7 5217.2 4854.299999999999 2642.3 4281.5 True False 4977.42406610898 5087.029193504828 5096.306210451616 4905.084077049351 4746.578551418665 5105.818220816913 4823.662403608184 4725.548195011368 4483.790114043561 4831.072230341662 1.030293862064026 1.0529813985300451 1.05490167968182 1.0153199627699325 0.9825103672860999 1.0568706029170298 0.9984662148731827 0.9781572226000786 0.9281148987760961 1.0 12.238127707619762 -7.628160212952927 2.631657524884015 0.962854863578525 1.031130091627041 0.5293635090657525 0.02675324209046232 0.21982190855310302 3.0579323204394058 0.015685289626690947 0.007870710650434279 2.3541806571257602e-08 7.628160212952927 0.06827522804851593 IDFSSIAVPGT(ph)SSPR ddPTM_A459_Selumetinib_30min_R1 1 IDFSSIAVPGTSSPR 15 0 Q5TDH0-2;Q5TDH0;Q5TDH0-3 Q5TDH0-2 DDI2 Protein DDI1 homolog 2 1 IDFSSIAVPGT(0.515)S(0.304)S(0.181)PR 186.29 5.2157e-05 65443000.0 2929.0 3335.8 3453.8 3681.5 3226.9 2610.1 3298.3 2991.3 1959.8 2643.2 True False 2997.240001158117 2945.242985228653 2984.792930365398 3038.595135313936 2935.0274647554666 2583.844763781185 3049.5065755234345 2911.9610068882243 3325.6374618713107 2982.4804669482846 1.00494874463501 0.9875145932614495 1.0007753490568472 1.0188147647528665 0.9840894172757575 0.866340883843243 1.022473276629279 0.9763554327206653 1.1150575833524734 1.0 11.542296974022952 -8.231378066061449 24.30287749864105 1.0575288150700435 0.9821315124585159 0.27250628569310487 0.04892249780751405 551.6863630959119 446008.7194664067 0.03294575201837924 0.01244910530919597 5.8697814838969e-09 8.231378066061449 -0.07539730261152755 IDFSSIAVPGTS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 IDFSSIAVPGTSSPR 15 0 Q5TDH0-2;Q5TDH0;Q5TDH0-3 Q5TDH0-2 DDI2 Protein DDI1 homolog 2 1 IDFSSIAVPGT(0.029)S(0.486)S(0.486)PR 142.95 0.00037935 51706000.0 2301.5 2589.7 2942.4 3455.5 2687.0 2300.6 2462.8 2218.4 1505.0 1856.7 True False 2355.1204720605688 2286.4967200811316 2542.838241446277 2852.06179276852 2443.9613244283796 2277.4580527776698 2277.0290131883457 2159.5608256212463 2553.875079149059 2095.0255307895286 1.1241488170184835 1.0913932486633924 1.2137504789681424 1.361349420736508 1.1665544350227328 1.087078901572808 1.0868741119017427 1.030804061279099 1.2190185950557886 1.0 11.032752109932304 -6.684180452550882 4.6304460227657875 1.0866541716025113 1.1989547676454508 0.2861500025101327 0.08495651195865694 0.3020756857635374 11.955332946567134 0.03046466692309756 0.030000810454016546 2.069281368513956e-07 6.684180452550882 0.11230059604293952 IDFSSIAVPGTSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 IDFSSIAVPGTSSPR 15 0 Q5TDH0-2;Q5TDH0;Q5TDH0-3 Q5TDH0-2 DDI2 Protein DDI1 homolog 2 1 IDFSSIAVPGT(0.065)S(0.034)S(0.9)PR;IDFSSIAVPGT(0.073)S(0.244)S(0.683)PR 103.66 0.005509600000000001 38627000.0 173467.0 181722.0 220774.0 211156.0 251669.0 173441.0 167122.0 167948.0 139774.0 235418.0 True False 163826.39858342 195659.49307167393 206569.64120055642 182396.18853558286 220052.09027059365 197330.92340936096 174893.5041459604 168436.70087471182 167732.70561186632 228620.87065057838 0.716585489842747 0.855825159421765 0.9035467348747664 0.7978107511205973 0.9625196931688658 0.8631360857292831 0.7649936055630971 0.7367512003405351 0.7336718871490396 1.0 17.802597586692997 -10.2843395266886 9.013878137530957 0.9999999973482316 0.8202677956426765 0.34098653322749584 0.07684819387311695 0.0 0.0 0.07969400370148871 0.019328634999388403 5.195896282034854e-11 10.2843395266886 -0.17973220170555515 IDFTPVS(ph)PAPSPTR ddPTM_A459_Selumetinib_30min_R2 1 IDFTPVSPAPSPTR 14 0 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309;Q7Z309-5 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 IDFTPVS(0.997)PAPS(0.002)PT(0.001)R 117.48 0.0024988 2019700.0 14508.0 13107.0 14714.0 14965.0 17377.0 12208.0 14754.0 13473.0 12891.0 11001.0 True False 13701.703440125555 14112.26475435245 13767.3172593919 12926.741183935079 15193.94590764896 13889.541186809816 15440.090234496363 13512.204199424774 15469.560204634425 10683.372545969363 1.2825260357783697 1.3209559709379175 1.2886677123869514 1.209986933275307 1.4222050052332353 1.3001082876259034 1.4452449512604164 1.2647882624408409 1.4480034406804245 1.0 13.383079531001956 -10.743512000759871 5.100728662059043 0.999965136628535 1.3293946153535827 0.6248439573340656 0.07701918053907819 2.9274810099656794e-05 4.473219004552669e-06 0.07149377419528838 0.017337954885658435 1.805044858051606e-11 10.743512000759871 0.3294294787250477 IDGATQS(ph)SPAEPK ddPTM_A459_Selumetinib_30min_R1 1 IDGATQSSPAEPK 13 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 IDGATQS(0.5)S(0.5)PAEPK 160.46 0.00036396 59325000.0 6133.0 7881.0 7811.6 7548.6 6110.1 6063.7 6042.7 5688.7 3590.6 5729.5 True False 6275.886967259387 6958.288856222502 6750.827626047352 6230.378714771366 5557.442533825772 6002.704683399089 5586.894273994319 5537.817196498186 6092.985952951899 6464.937135056071 0.9707576169965272 1.0763119131493537 1.0442216969815594 0.9637183756957489 0.8596282404187016 0.9285016324210593 0.8641838516417163 0.8565925825433653 0.9424663884065833 1.0 12.658420626022627 -5.969822405955295 3.771466101754141 0.9003832565066151 1.0340288684439736 0.5552203388485702 0.048425217983753856 0.14442683606720078 4.452315423390175 0.013639664532938066 0.020239385933948792 1.0719575662999798e-06 5.969822405955295 0.13364561193735847 IDGATQS(ph)SPAEPK ddPTM_A459_Selumetinib_30min_R2 5 IDGATQSSPAEPK 13 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 IDGAT(0.004)QS(0.498)S(0.498)PAEPK;IDGAT(0.009)QS(0.496)S(0.496)PAEPK;IDGAT(0.014)QS(0.493)S(0.493)PAEPK;IDGAT(0.002)QS(0.499)S(0.499)PAEPK;IDGAT(0.004)QS(0.498)S(0.498)PAEPK 192.39 0.00017871 373006700.0 490537.0 427017.0 497387.0 503814.0 451252.0 339038.0 393960.0 386255.0 311613.0 409213.0 True False 463274.9173151961 459767.83082393446 465385.66193401883 435193.66407237266 394561.6895159357 385737.40701946465 412279.9206169308 387378.93810204254 373944.30719468964 397397.9574269395 1.1657707561327058 1.156945631529728 1.171082168985679 1.0951079539767936 0.9928629026445733 0.9706577495189602 1.0374485145478567 0.9747884478577399 0.9409819557601482 1.0 18.60022493178132 -6.094187928404533 2.4555548700994456 0.9852113933351369 1.164189252464034 0.9222341059847472 0.023545843178201624 0.0768997774560763 0.9109025771547641 0.007802084442299745 0.011115018123565417 8.050300123112929e-07 6.094187928404533 0.1789778591288972 IDGATQSS(ph)PAEPK ddPTM_A459_Selumetinib_30min_R1 5 IDGATQSSPAEPK 13 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 IDGATQS(0.225)S(0.775)PAEPK;IDGATQS(0.225)S(0.775)PAEPK;IDGATQS(0.188)S(0.812)PAEPK;IDGATQS(0.079)S(0.921)PAEPK;IDGAT(0.003)QS(0.019)S(0.978)PAEPK 206.67 4.8511e-10 73456200.0 17483.7 20506.500000000004 21737.100000000002 22450.3 17193.100000000002 17439.6 18592.800000000003 18006.5 9907.800000000001 15702.9 True False 17891.03619264192 18105.589446786795 18785.321213343486 18529.776549324593 15637.98714068835 17264.17345788988 17190.330126850848 17528.909126644863 16812.812962918957 17718.52017419879 1.0097364800641953 1.0218454627577558 1.0602082470012446 1.0457857861237831 0.882578623211432 0.9743575246780192 0.9701899457655002 0.9892987086003924 0.9488835860796829 1.0 14.11297049661982 -6.204580086531384 24.99991738516949 0.9614883558281633 1.0353416030575449 0.5536944071514105 0.032324499690888644 217.01991622699495 95419.19980035433 0.009551644084113032 0.012331115377658321 6.243382079194986e-07 6.204580086531384 0.07385324722938158 IDGATQSS(ph)PAEPK ddPTM_A459_Selumetinib_30min_R2 2 IDGATQSSPAEPK 13 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 IDGAT(0.001)QS(0.281)S(0.718)PAEPK;IDGATQS(0.225)S(0.775)PAEPK 211.82 5.3312e-06 179142900.0 316376.0 279239.0 292090.0 286676.0 298193.0 212835.0 259694.0 253790.0 197948.0 262389.0 True False 298793.0884734743 300655.73340509797 273297.2474035468 247630.23425631635 260731.3294607566 242151.08932623448 271770.28557389864 254528.48688280382 237543.1311292355 254813.14780150514 1.172596826542988 1.1799066727879497 1.0725398189281836 0.9718110560339526 1.023225574152326 0.9503084570615086 1.0665473423121903 0.9988828640862635 0.9322247818792981 1.0 17.959080193862505 -5.453759728099513 2.794240593048643 0.9945745539283002 1.178089119859626 0.8071306399202925 0.03586670911684046 0.10958429422670093 1.6592282819025146 0.009888972357805724 0.023519642371317477 3.517549939232972e-06 5.453759728099513 0.18351456593132576 IDHYLGK ddPTM_A459_Selumetinib_30min_R2 1 IDHYLGK 7 0 P11413-3;P11413;P11413-2;E7EUI8;E9PD92;E7EM57 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 87.323 0.047408 19658000.0 167570.0 154580.0 174880.0 181250.0 186760.0 140090.0 153310.0 150800.0 126970.0 166410.0 False True 158257.13023585884 166435.78894695957 163628.41119494752 156563.4373263102 163297.5391444163 159386.12588959586 160439.21877800187 151238.80303371625 152367.5478382156 161605.3109148948 0.979281741051201 1.0298905896391526 1.0125187734771794 0.9688013125308749 1.0104713652041588 0.9862678706984598 0.9927843204515289 0.935852925733129 0.9428375031465146 1.0 17.302115085303 -7.662433570946355 6.496693100955052 0.954744159712324 0.9983989508077314 0.35482300502285735 0.022985644427163637 0.20051160657879039 11.169855753567274 0.010799915390879117 0.0061453312881733346 2.1755367755187947e-08 7.662433570946355 0.043654791095407486 IDIFPAKENGDLS(ph)PFSGTSLR ddPTM_A459_Selumetinib_30min_R1 1 IDIFPAKENGDLSPFSGTSLR 21 1 V9GY71;V9GYH5;P19174 V9GY71 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1 IDIFPAKENGDLS(0.588)PFS(0.147)GT(0.119)S(0.147)LR 57.432 0.015141 7501500.0 574.68 835.12 1076.6 1145.4 802.53 832.69 1050.3 903.38 498.5 488.72 True False 588.0689258673771 737.3437621632447 930.4036333404914 945.3773918208835 729.9413031981794 824.3138946220276 971.0750253986183 879.4194278082052 845.918091000535 551.4519725359285 1.0664009835037138 1.3370951576661645 1.6871888753283466 1.7143422073067114 1.3236715789435713 1.4948063216299794 1.7609421559106861 1.5947343950264117 1.5339832535378615 1.0 9.10709143279639 -4.931371316882774 3.385513123977909 1.5430609170634757 1.066720071135183 0.28957755109433225 0.21175335486338556 0.28919051635071275 6.136879647529517 0.051779827086375706 0.29203015665968346 1.1711935800527367e-05 4.931371316882774 -0.47634084592829273 IDILDSALLRPGR ddPTM_A459_Selumetinib_30min_R1 2 IDILDSALLRPGR 13 1 P62195-2;P62195 P62195-2 PSMC5 26S protease regulatory subunit 8 0 ; 190.36 0.00032584 6974900.0 3718.6 3364.6 4219.6 3993.0 4178.9 3498.2 3300.3 3626.6000000000004 2358.3 3031.3999999999996 False True 3805.2361448639745 2970.6710678398977 3646.6014966036932 3295.6975078931246 3800.9192328447193 3463.0112841114674 3051.3557139132254 3530.410787142992 4001.862856582873 3420.509718336497 1.1124763436469878 0.8684878314816278 1.0660988556925228 0.9635106400153506 1.1112142767696118 1.0124255065106613 0.8920763176188832 1.0321300267668714 1.1699609666740274 1.0 11.73999561366857 -8.010828185657546 24.953460497072403 1.09033550354978 1.000886172232572 0.1211971435986906 0.08618414030968977 907.5401774894126 2091407.4248577482 0.04951978873276756 0.02124257571141818 9.753754366422969e-09 8.010828185657546 -0.089449331317208 IDIS(ph)PSTFR ddPTM_A459_Selumetinib_30min_R1 5 IDISPSTFR 9 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 IDIS(0.974)PS(0.026)TFR;IDIS(0.488)PS(0.488)T(0.024)FR;IDIS(0.998)PS(0.002)TFR;IDIS(0.936)PS(0.064)TFR;IDIS(0.998)PS(0.002)TFR 164.33 0.00091553 3318520000.0 18868.699999999997 23821.7 20533.6 20505.8 19899.5 18388.0 20854.2 19289.7 10647.779999999999 18273.8 True False 19308.303997901043 21032.64428959212 17745.24990299118 16924.8469715389 18099.59373854207 18203.033414968177 19281.150904187267 18778.074494223834 18068.504976918095 20619.42023188543 0.9364135257325565 1.0200405274765045 0.8606085769351705 0.820820701125567 0.8777935332319987 0.8828101474366091 0.9350966558395909 0.9106984717827237 0.8762857914393416 1.0 14.33171614773836 -10.17391082854215 14.782645922064095 0.9999975143263933 0.9020462472596574 0.24691840720634517 0.051193205722131256 0.0 0.0 0.05414771015638069 0.013132748727063989 6.700221675081447e-11 10.17391082854215 -0.09795126706673585 IDIS(ph)PSTFR ddPTM_A459_Selumetinib_30min_R2 6 IDISPSTFR 9 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 IDIS(0.993)PS(0.004)T(0.003)FR;IDIS(0.996)PS(0.004)TFR;IDIS(0.939)PS(0.061)TFR;IDIS(0.959)PS(0.035)T(0.006)FR;IDIS(0.999)PS(0.001)TFR;IDIS(0.992)PS(0.008)TFR 144.55 0.0019369 1930719000.0 1213685.0 1078828.0 1453864.0 1546830.0 1500246.0 882412.0 1235019.0 1164966.0 1159448.0 1071387.0 True False 1146233.246466003 1161570.6386212371 1360323.9730874347 1336149.0855694162 1311771.6851105902 1003956.2432614042 1292449.8306437207 1168355.8581894974 1391369.9976838897 1040453.2735122679 1.1016672018308449 1.1164082695420932 1.3074339883571862 1.2841990309271316 1.2607694343470421 0.9649219900787469 1.242198821943042 1.1229296768373533 1.3372729300827022 1.0 19.98878074479066 IDIS(ph)PSTLR ddPTM_A459_Selumetinib_30min_R1 4 IDISPSTLR 9 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 IDIS(0.841)PS(0.158)T(0.001)LR;IDIS(0.57)PS(0.333)T(0.097)LR;IDIS(0.477)PS(0.477)T(0.047)LR;IDIS(0.673)PS(0.287)T(0.04)LR 133.91 0.0030091 1796889000.0 10590.0 12907.399999999998 10614.1 10396.7 10754.9 9681.400000000001 12042.0 10869.9 5459.6 9543.199999999999 True False 10836.726395447067 11396.19560751253 9172.76351907794 8581.111515229768 9782.121193931813 9584.013906007882 11133.662244930178 10581.594941588699 9264.542446592817 10768.162678639856 1.0063672623504487 1.0583231278738447 0.851841097950107 0.7968965339139603 0.9084299230857653 0.890032421688716 1.033942611864078 0.9826741346115396 0.8603642722607008 1.0 13.394484490105688 -9.358969634066158 14.886072838032128 0.9999999971930537 0.9320213228359236 0.05867402483060291 0.08159353716985285 0.0 0.0 0.08575783061383845 0.020799329049687284 4.375526978374952e-10 9.358969634066158 -0.06797867435713001 IDIS(ph)PSTLR ddPTM_A459_Selumetinib_30min_R2 6 IDISPSTLR 9 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 IDIS(0.879)PS(0.12)T(0.001)LR;IDIS(0.6)PS(0.398)T(0.002)LR;IDIS(0.881)PS(0.119)TLR;IDIS(0.872)PS(0.128)TLR;IDIS(0.995)PS(0.004)TLR;IDIS(0.988)PS(0.011)T(0.001)LR 123.62 0.0055697 1267554500.0 121543.0 101616.7 127793.7 127612.0 143298.0 103106.0 113377.0 113000.0 104320.1 104174.5 True False 114788.12663517924 109410.37414081086 119571.59247325991 110231.02545702123 125295.62413962616 117307.91559692107 118649.25515226343 113328.81129184282 125187.03494713224 101166.71150714334 1.1346432529545463 1.0814859207228995 1.1819262551083023 1.089597791752259 1.2385064441951252 1.1595505463142193 1.1728092510339794 1.1202183959873078 1.237433075387578 1.0 16.626375129647542 -5.26223631455153 24.999879840848674 1.1564574180669653 1.1080645872341917 0.051298522377431044 0.06774213148624071 176.06711694398547 5523365.231825475 0.016183799249817585 0.03696064242429508 5.467183936772774e-06 5.26223631455153 -0.04839283083277368 IDISPS(ph)TLR ddPTM_A459_Selumetinib_30min_R1 1 IDISPSTLR 9 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 IDIS(0.115)PS(0.812)T(0.073)LR 114.89 0.0083395 1490300000.0 4962.9 6013.3 4703.0 5569.9 5167.3 5140.4 5538.9 4681.7 2770.0 4150.2 True False 5078.525913877643 5309.260040492672 4064.3584317298255 4597.22152497218 4699.918627360912 5088.692243109767 5121.096313606025 4557.526107695181 4700.487687204577 4682.918596371359 1.0844787944451624 1.1337502310218768 0.867911399288291 0.9817000723724767 1.0036302213330648 1.086649733149927 1.0935693645356543 0.9732234319056197 1.003751739534151 1.0 12.193192244409062 -8.423490489789872 0.004770521199290062 9.250953078205368e-08 2.0277276628018406 0.02743667956726703 0.07286238081084367 35800.438289672355 124.48947684277567 26592.606636098473 26313.10395721852 3.771460036898347e-09 8.423490489789872 2.02772757029231 IDISPS(ph)TLR ddPTM_A459_Selumetinib_30min_R2 2 IDISPSTLR 9 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 IDIS(0.388)PS(0.608)T(0.004)LR;IDIS(0.145)PS(0.854)T(0.001)LR 123.62 0.0055697 676595000.0 70194.0 53028.0 60264.0 69712.0 71540.0 55654.0 58878.0 62553.0 58194.0 56190.0 True False 66292.8984888457 57095.07708810574 56386.67985048204 60217.10534009244 62552.50562428541 63319.833323289145 61615.943664543665 62735.01887379338 69834.42607621558 54567.64870084705 1.214875481483164 1.04631734090495 1.0333353404983117 1.103531245596032 1.1463295031679532 1.1603914559416637 1.129166184204437 1.1496742184681956 1.2797770792555982 1.0 15.735758259420697 -6.228114270210692 4.07001101329608 1.1521790340541656 1.0897976164254162 0.06453293492198686 0.07799491521291471 0.4904791039482131 18.412326210377138 0.023359901333339404 0.02960266445613724 5.914060047970225e-07 6.228114270210692 -0.06238141762874938 IDLPEVQIEHDPELEKES(ph)PGLK ddPTM_A459_Selumetinib_30min_R2 2 IDLPEVQIEHDPELEKESPGLK 22 1 Q14966-3;Q14966;Q14966-5 Q14966-3 ZNF638 Zinc finger protein 638 1 IDLPEVQIEHDPELEKES(1)PGLK;IDLPEVQIEHDPELEKES(1)PGLK 77.969 0.00064084 11271100.0 58226.0 46811.0 47507.0 48516.0 45129.0 32218.0 42699.0 47304.0 29459.3 43065.0 True False 54990.032017145786 50401.25317891145 44450.45134171066 41908.037105231815 39459.49156162112 36655.737054115205 44684.58810646336 47441.64680840123 35351.983161615644 41821.601553692446 1.3148715011917256 1.2051488060351794 1.0628586589311548 1.0020667680894142 0.9435193798343963 0.8764785587432592 1.0684571237448972 1.1343813973143404 0.8453043845350873 1.0 15.351960690384834 -5.157762627209482 1.5510860593848632 0.9835754570698698 1.3393425477223602 0.6688649585442572 0.07927343725642207 0.3601575408761386 1.30998405231647 0.02413153348497714 0.15699528618304384 6.954043015937615e-06 5.157762627209482 0.35576709065249035 IDNDGDGFVTTEELK ddPTM_A459_Selumetinib_30min_R2 1 IDNDGDGFVTTEELK 15 0 Q15293;Q15293-2 Q15293 RCN1 Reticulocalbin-1 0 120.14 0.023936 0.0 8902.2 9416.7 9722.5 9492.8 9637.5 8544.5 5918.0 5921.1 6040.0 9403.4 False True 8407.45136233014 10138.93061053717 9096.964935057607 8199.864264006606 8426.751089656836 9721.427315751678 6193.198726294532 5938.329420709126 7248.168771700569 9131.899409032661 0.9206684158187346 1.1102762039306326 0.9961744569875026 0.8979363324891481 0.9227818564582151 1.0645569864836548 0.6781939275599812 0.6502841473303275 0.7937197342024122 1.0 13.156699252537337 -7.262422616952651 24.99802689041234 0.7514064604421146 0.9847432565492028 0.4542483737673848 0.10812707621548957 72.51284071993125 1843543.8419776687 0.0426451673108686 0.030630780373627504 5.464839142857041e-08 7.262422616952651 0.23333679610708824 IDRDSYS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 IDRDSYSPR 9 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 IDRDSYS(1)PR 132.56 0.015819999999999997 40731000.0 3068.6 3281.4 3447.5 3953.6 3036.7 2926.4 3051.3 2729.2 1784.1 2663.7 True False 3140.092409543803 2897.2121625185273 2979.348435761976 3263.1779782635285 2762.0310211729284 2896.963072958606 2821.1379843842774 2656.81275030901 3027.487394491584 3005.611841635196 1.044743158795729 0.9639342387413226 0.9912618770296927 1.085695076476743 0.9189579914851054 0.9638513639148162 0.938623525933889 0.8839507196190635 1.007278236182516 1.0 11.553442989755846 -6.287080484251443 24.998793723285907 0.9462205548459592 1.0151499586579906 0.3507823583415297 0.04544851612376061 845.5117850483601 824328.7838111871 0.013798437783954471 0.01565116807982336 5.163206749089557e-07 6.287080484251443 0.06892940381203139 IDRDSYS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IDRDSYSPR 9 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 IDRDSYS(1)PR 113.67 0.042628 24241000.0 68867.0 84806.0 117570.0 95986.0 126070.0 85526.0 51236.0 63784.0 88391.0 106560.0 True False 65039.64783644383 91310.3475057308 110005.67420053743 82912.54121491432 110231.95951990028 97306.43017227198 53618.57552220793 63969.600879990394 106071.66985089156 103483.33592386986 0.6285035871310903 0.882367645868177 1.0630279089714105 0.8012163550265816 1.0652145926276981 0.9403101407926966 0.5181372927681206 0.6181633043512557 1.0250120843507198 1.0 16.659038941527754 IDRVS(ph)PY(ph)RPGWS(ph)T(ph)VT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 IDRVSPYRPGWSTVTR 16 2 J3KTQ7 J3KTQ7 TMCO1 5 IDRVS(1)PY(1)RPGWS(1)T(1)VT(1)R 66.939 0.029689 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 489.89 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 587.8816886702631 0.0 0.0 IDS(ph)LSAQLSQLQK ddPTM_A459_Selumetinib_30min_R1 1 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 IDS(0.998)LS(0.002)AQLSQLQK 169.98 0.00023965 14858000.0 2702.2 3624.6 2644.3 2915.1 3033.7 3011.3 3000.8 3074.7 1608.6 2990.0 True False 2765.156002434095 3200.2301469691765 2285.218584100188 2406.03250820417 2759.302370643235 2981.0090560416406 2774.4472400420605 2993.1489679668443 2729.676712504435 3373.795625066347 0.8195979572353964 0.9485548333729441 0.6773435139703367 0.7131530109079605 0.817862928667759 0.8835772486909363 0.8223518992759082 0.8871755436899006 0.8090818223320076 1.0 11.720156866576335 -6.606231173783978 5.101790051621593 0.869189695694414 0.7899006661699477 0.20944684428203575 0.08254286062041342 0.3993235941692432 17.980305832826577 0.028557141459462372 0.02859253068156552 2.476103683453696e-07 6.606231173783978 -0.07928902952446626 IDS(ph)LSAQLSQLQK ddPTM_A459_Selumetinib_30min_R2 2 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 IDS(0.993)LS(0.007)AQLSQLQK;IDS(0.99)LS(0.009)AQLS(0.001)QLQK 157.68 0.00036484 13863300.0 71815.0 58711.0 56407.0 55707.0 58473.0 48175.0 47530.0 48943.0 45722.0 42797.0 True False 67823.80979822291 63213.94491438057 52777.83503129801 48119.610500064904 51127.09898474751 54810.66896089142 49740.239178908254 49085.41602705019 54867.67757941941 41561.33941004008 1.6318966318452803 1.5209794922805067 1.2698781074064311 1.1577973949617353 1.2301600408093827 1.3187897632493208 1.1967910535359787 1.1810354700742032 1.3201614374864177 1.0 15.342954528716618 -5.2045904798700935 2.543953183546209 1.2131843874351917 1.6220500028205231 0.7530951556038324 0.08571723603154004 0.14026193905222598 1.7075730776618234 0.022086748386332265 0.08074258898100527 6.243232667192534e-06 5.2045904798700935 0.4088656153853314 IDS(ph)LSLNGEFGYQK ddPTM_A459_Selumetinib_30min_R2 1 IDSLSLNGEFGYQK 14 0 Q8TEQ0-2;Q8TEQ0 Q8TEQ0-2 SNX29 Sorting nexin-29 1 IDS(0.642)LS(0.358)LNGEFGYQK 121.99 0.0020906 0.0 12070.0 9879.4 12500.0 12456.0 10747.0 8835.5 9813.6 11137.0 8327.0 11331.0 True False 11399.197720038288 10637.118212722176 11695.763608970963 10759.4713122015 9396.865780600994 10052.509924316682 10269.951845279485 11169.406826170405 9992.632675819636 11003.844588526386 1.03592863642623 0.9666728866575786 1.0628797521519011 0.9777920094782425 0.8539620588970354 0.9135452471582839 0.9333057880504669 1.0150458538660796 0.9081037627738643 1.0 13.425720048730462 -6.0016100030083095 24.991129469912885 0.9347972303400848 1.016982385814188 0.37955389890626456 0.048361714657082916 66.9562432552992 1039366.9171975324 0.013807246175479515 0.02015363009937677 9.96299694140647e-07 6.0016100030083095 0.08218515547410321 IDS(ph)PGFKPASQQK ddPTM_A459_Selumetinib_30min_R2 2 IDSPGFKPASQQK 13 1 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 IDS(1)PGFKPASQQK;IDS(1)PGFKPASQQK 138.81 0.0045956 181732000.0 402110.0 349650.0 380330.0 393880.0 380470.0 259630.0 350270.0 338520.0 214779.0 316770.0 True False 379762.33597386885 376467.0306980492 355859.98187199375 340232.8645191006 332671.95715504384 295391.6758135187 366558.2490468382 339505.03715499694 257740.8014266676 307624.0270326982 1.2345015427988753 1.2237894235031044 1.1568016494178732 1.1060022450162394 1.0814238418369162 0.9602360344308238 1.191578735193775 1.1036362810467661 0.8378435322910314 1.0 18.230808664105794 -2.4677892635827536 0.2277486703474451 0.9690153714835553 2.076140459353613 0.5011850658115263 0.08433813544383734 29.658189232584405 0.5615462164243061 0.130974583738821 11.16256698981677 0.0034057340895369144 2.4677892635827536 1.1071250878700578 IDS(ph)PPIRR ddPTM_A459_Selumetinib_30min_R2 1 IDSPPIRR 8 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 IDS(1)PPIRR 66.92 0.041510000000000005 9780900.0 34410.0 29707.0 35036.0 42908.0 32004.0 26014.0 28272.0 25248.0 15805.0 25717.0 True False 32497.62995414395 31985.431376939658 32781.82190431253 37063.85637957143 27983.371400609874 29597.19236841995 29586.70401990519 25321.467499968585 18966.441628597262 24974.48338920953 1.3012333207334679 1.280724444965267 1.3126126131792675 1.4840689916166687 1.1204784885640664 1.1850972813799105 1.1846773187984507 1.013893545077652 0.759432791182055 1.0 14.608167214943158 -7.528196808284661 1.0097608910066487 0.8804942876957828 1.314891483080473 0.7120340332102938 0.10361945986226934 0.29878472266227646 0.5627381023555456 0.08594191855623189 0.04004901668833266 2.9634881277241565e-08 7.528196808284661 0.43439719538469024 IDSFSVQS(ph)LDSR ddPTM_A459_Selumetinib_30min_R1 1 IDSFSVQSLDSR 12 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 IDSFSVQS(1)LDSR 162.67 0.00049361 5932300.0 936.27 948.26 1046.0 1393.3 914.26 1166.2 946.51 950.45 535.0 958.61 True False 958.0832693357157 837.2372783658864 903.958945266723 1149.9863104802137 831.5653444257135 1154.4690868248802 875.1139886604267 925.240978503297 907.8559251460109 1081.6569311521243 0.8857552165964633 0.7740321854861181 0.8357168703240068 1.063171027116064 0.7687884397319709 1.067315387694322 0.8090494901449955 0.8553922707431633 0.8393196576469124 1.0 10.07902727716526 -5.553961251383974 24.99998297049365 0.9080208551562298 0.823638505039013 0.12228427456081836 0.1004471895449381 386.8036400057469 311108.5019614368 0.025992514678049965 0.04502083570461904 2.792793008659267e-06 5.553961251383974 -0.08438235011721673 IDSLS(ph)AQLSQLQK ddPTM_A459_Selumetinib_30min_R1 1 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 IDS(0.114)LS(0.886)AQLSQLQK 167.22 0.00031163 16425000.0 2033.9 2731.3 2114.1 2206.6 2035.2 2072.9 2377.5 2024.5 1304.5 2324.9 True False 2081.285912719527 2411.5181262530778 1827.0168319200568 1821.258733012015 1851.116519343744 2052.04850804261 2198.163260863768 1970.8036834972102 2213.641223089664 2623.3235614437303 0.7933775090915982 0.9192606515247831 0.6964511960219536 0.6942562327346674 0.7056378963504575 0.7822323323750722 0.8379306667203575 0.7512621441224697 0.843830801363824 1.0 11.35718004563954 -8.938260654264617 1.019564640322093 1.0008096643210413 0.7689336570005932 0.5191081740479805 0.06617672880652492 1.2660697674233043 2.1075719959456576 0.06946983816964912 0.02206764269826744 1.152761187535482e-09 8.938260654264617 -0.2318760073204481 IDSLS(ph)LNGEFGYQK ddPTM_A459_Selumetinib_30min_R2 2 IDSLSLNGEFGYQK 14 0 Q8TEQ0-2;Q8TEQ0 Q8TEQ0-2 SNX29 Sorting nexin-29 1 IDSLS(1)LNGEFGYQK;IDS(0.001)LS(0.999)LNGEFGYQK 139.21 0.00060614 0.0 18517.8 14588.900000000001 16814.6 17839.2 18539.4 15620.2 15942.8 14940.7 13438.199999999999 14889.9 True False 17488.654808626765 15707.82171929292 15732.76694235225 15409.470185663518 16210.314827661125 17771.740763942216 16684.17179005889 14984.17496343396 16126.215494679882 14459.989898393707 1.209451384925898 1.086295483583832 1.0880206039493796 1.0656625830267892 1.1210460686049202 1.2290285739353384 1.153816282535042 1.0362507213852536 1.1152300664104384 1.0 13.81977892398631 -8.673711737110859 1.0305698626340603 1.0030271496925773 1.128295647652329 0.31113872392558095 0.056703305305303105 0.9740398266054561 2.1406625324609054 0.05746162168840179 0.01864089590070972 2.1197676638347857e-09 8.673711737110859 0.1252684979597516 IDSNIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 IDSNISPK 8 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 IDS(0.003)NIS(0.997)PK 86.014 0.034466000000000004 79572000.0 6320.3 6278.6 6469.7 7098.2 4885.8 5721.2 4752.8 5110.6 3986.5 6167.6 True False 6467.550692837025 5543.498593158047 5591.150275518274 5858.63261971625 4443.880252658049 5663.649922433976 4394.292469498767 4975.050286431635 6764.799337559949 6959.271537511445 0.9293430581025649 0.7965630545205509 0.8034102772655433 0.8418456713662346 0.6385553759046352 0.8138279835620887 0.6314299486394398 0.7148808980387414 0.9720556671911329 1.0 12.764720584382369 -8.275110707609352 20.136532732058182 0.9860291955217589 0.7678400619676694 0.49812503519587936 0.08618732887964278 56.5124704361646 83225.6287233975 0.0821020318436859 0.022017409109536583 5.3074913176506085e-09 8.275110707609352 -0.21818913355408953 IDSNIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 IDSNISPK 8 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 IDS(0.001)NIS(0.999)PK 85.92399999999998 0.034593 224310000.0 1047800.0 930560.0 895900.0 895550.0 793680.0 636380.0 776540.0 740940.0 553800.0 746000.0 True False 989567.4706757354 1001930.959777997 838258.7693821674 773574.5450900792 693970.8228107755 724035.5685175317 812650.6486848181 743096.012730779 664575.4744648614 724461.0416592271 1.3659360735386643 1.3830018484959286 1.1570791542666121 1.0677931601654767 0.9579132388145812 0.9994127039036896 1.1217313312301942 1.02572253026729 0.9173377673184326 1.0 19.46654858448646 -5.466795477836248 1.9324432357143748 1.0118695947589689 1.390380343844344 0.8835769679150364 0.05228029205080399 0.11526599958814406 0.824445784119975 0.016112764852774835 0.046476436432909274 3.413536273324029e-06 5.466795477836248 0.3785107490853752 IDSVAAQPT(ph)ATSPVVYTR ddPTM_A459_Selumetinib_30min_R1 1 IDSVAAQPTATSPVVYTR 18 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IDSVAAQPT(0.691)AT(0.109)S(0.2)PVVYTR 111.7 0.0030128 6808400.0 1916.1 2680.3 1697.6 1757.1 1853.6 2043.3 2481.1 2556.1 1382.8 2311.5 True False 1960.741401918425 2366.4892299623366 1467.0752442493194 1450.2554698519932 1685.94220727966 2022.7462571679623 2293.94862945493 2488.3039246170506 2346.5106042839307 2608.2035409166783 0.7517593512772027 0.9073253650789121 0.5624849522801053 0.5560361555763731 0.6463997846913125 0.7755323637268925 0.8795128882651159 0.9540298084797907 0.8996654469149393 1.0 11.348840744726811 -7.2183442304532 2.1672034726031364 0.9423391450154034 0.6843841294927766 0.5966192822351242 0.09705074744292498 0.2585949170386758 2.3770263061355736 0.05205675658739748 0.03484873843582917 6.048612596255507e-08 7.2183442304532 -0.2579550155226268 IDSVAAQPTAT(ph)SPVVYTR ddPTM_A459_Selumetinib_30min_R1 1 IDSVAAQPTATSPVVYTR 18 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IDSVAAQPT(0.009)AT(0.951)S(0.04)PVVYTR 228.26 2.389e-18 5186700.0 2897.9 4159.6 2074.4 2363.2 2701.5 2686.8 3066.2 2710.4 1740.5 2643.5 True False 2965.4154316681843 3672.592098254421 1792.7078738635653 1950.5114827580867 2457.1498019885644 2659.7732314192117 2834.9140653882178 2638.5113873800155 2953.5013789095924 2982.8189748705336 0.9941654041532626 1.2312487379204187 0.6010112879684145 0.6539154736477921 0.823767658275412 0.8916978381279932 0.9504143862807714 0.8845697340699455 0.9901711782686331 1.0 11.542460708871811 -7.098729654420215 3.5238597002730527 0.9466728684707464 0.8555300798324112 0.06677980035846487 0.16600363891958173 0.9207028664654456 21.228474069162306 0.07423754416371199 0.05704073649004792 7.966551088859706e-08 7.098729654420215 -0.09114278863833514 IDSVAAQPTATS(ph)PVVYTR ddPTM_A459_Selumetinib_30min_R2 2 IDSVAAQPTATSPVVYTR 18 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IDSVAAQPT(0.001)AT(0.082)S(0.918)PVVYTR;IDSVAAQPTAT(0.209)S(0.791)PVVYTR 251.0 5.2163e-33 18204100.0 85929.0 76804.0 88470.0 98867.0 110125.0 89280.0 104662.0 117673.0 115050.0 90595.0 True False 81153.4101810414 82694.6198362163 82777.93651885282 85401.14404491193 96290.11297000869 101577.50959685295 109528.99038381848 118015.40894818603 138063.21476558794 87979.28695592145 0.9224149568488788 0.9399328262076866 0.9408798295935887 0.9706960240277783 1.0944634390848276 1.1545616373061123 1.244940646526195 1.3413999252723314 1.569269535393701 1.0 16.4248762882614 -6.805552285678533 1.1219631711794986 1.3313845034447962 0.9327045927292777 0.5779826869143955 0.13130078850645047 0.31910482424576486 0.8500081461420166 0.06873815350754674 0.059442416003601325 1.5647599229572755e-07 6.805552285678533 -0.39867991071551845 IDT(ph)PPACTEESIATPSEIK ddPTM_A459_Selumetinib_30min_R2 2 IDTPPACTEESIATPSEIK 19 0 O94913 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 IDT(1)PPACTEESIATPSEIK;IDT(1)PPACTEESIATPSEIK 209.25 4.0488999999999986e-30 0.0 72017.0 53726.0 49424.0 44304.0 43371.0 39060.0 63731.0 55040.0 33438.0 39654.0 True False 68014.5834468929 57846.611443682 46244.11364878243 38269.718771337095 37922.34723834051 44440.16044862316 66694.61778058071 55200.15728763746 40126.53433578204 38509.08598653475 1.7661957354862994 1.5021548801212494 1.2008624059514772 0.9937841366766961 0.9847636282928293 1.1540175340479981 1.7319190022817323 1.433432029701743 1.0420017330406868 1.0 15.232911260712328 -5.006597068584951 2.644167779356548 1.2117691686093128 1.7714179132016674 0.40692349478824996 0.22316912352238127 0.369304062971335 4.5976016097917425 0.06569526615072459 0.3671069453317539 9.849244790337301e-06 5.006597068584951 0.5596487445923546 IDTHPS(ph)PSHSSTVK ddPTM_A459_Selumetinib_30min_R2 3 IDTHPSPSHSSTVK 14 0 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;H7C477;B7ZBA0 A0A0C4DG98 THOC2 THO complex subunit 2 1 IDTHPS(0.817)PS(0.133)HS(0.001)S(0.018)T(0.03)VK;IDT(0.004)HPS(0.819)PS(0.172)HS(0.002)S(0.002)T(0.001)VK;IDT(0.086)HPS(0.908)PS(0.006)HSSTVK 105.0 0.003956 26323100.0 93192.0 64116.2 154346.0 249098.0 275424.0 158175.0 122082.0 159533.0 195258.0 188610.0 True False 88012.76171713413 69033.70637392323 144415.5463992187 215170.42268198173 240822.77479819916 179962.17048031164 127759.05490089364 159997.21461788996 234315.05596435562 183164.33923236805 0.48051253910008307 0.37689490576189555 0.7884479424567934 1.1747397096167818 1.3147907273188357 0.982517509874048 0.6975105276295867 0.8735172757340742 1.2792613286317494 1.0 17.48277912295611 -5.45441204325827 3.5756396718366266 1.0337222634204657 0.43397916469094466 0.658322135921495 0.17650899568399678 0.15611287705730825 3.850747132147825 0.05320491873728544 0.11722157014332732 3.512270505843153e-06 5.45441204325827 -0.599743098729521 IDTHPSPS(ph)HSSTVK ddPTM_A459_Selumetinib_30min_R2 1 IDTHPSPSHSSTVK 14 0 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;H7C477;B7ZBA0 A0A0C4DG98 THOC2 THO complex subunit 2 1 IDTHPS(0.419)PS(0.57)HS(0.003)S(0.003)T(0.005)VK 82.069 0.020248 15199000.0 22147.0 16545.0 37224.0 65682.0 70704.0 40026.0 30568.0 42433.0 49330.0 49543.0 True False 20916.158401465444 17813.948299440097 34829.04836642678 56735.998292230164 61821.53141822024 45539.21818014825 31989.47256934288 42556.473004838685 59197.37839536241 48112.5648618271 0.4347338052239342 0.3702556359362547 0.7239075378012206 1.1792345399828177 1.2849352678611807 0.9465140407901936 0.6648881152192239 0.8845189011863164 1.2303933196114034 1.0 15.554126090522393 -5.488944701382776 3.6515490976845517 1.0137368837061118 0.41197075678232414 0.6773001449792423 0.17260475229974506 0.1474647490195252 4.094185719970901 0.05290103590338913 0.11223697619021168 3.2438091806812394e-06 5.488944701382776 -0.6017661269237877 IDTIEIITDR ddPTM_A459_Selumetinib_30min_R1 2 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 197.27 0.00097923 23150000.0 6123.9 7029.700000000001 5399.2 5716.3 6198.0 4888.0 6087.6 6026.0 5226.5 7260.9 False True 6266.574954964901 6206.659455981132 4666.018295682685 4718.055513240541 5637.391994345778 4838.8311579489055 5628.407430845125 5866.170904793374 8868.988771543225 8192.90724215527 0.7648780548522824 0.7575649610733753 0.5695192387476874 0.5758707347453605 0.6880819991882119 0.5906122228568008 0.68698537216253 0.7160060197691421 1.0825203446597427 1.0 13.000159765782044 -8.194284499327981 4.342854480247566 1.0432036620391738 0.6600424495071835 0.8266068320394735 0.06844077027748345 0.08495523411658076 3.054412992279333 0.05622596042136257 0.018892835737617835 6.3931589272056196e-09 8.194284499327981 -0.3831612125319903 IDTIEIITDR ddPTM_A459_Selumetinib_30min_R2 4 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ;;; 170.47 0.0028245 49299600.0 117987.0 102060.0 134887.0 137603.0 135595.0 115362.0 117098.0 123115.0 112581.0 117706.0 False True 111429.75487938346 109887.67382537645 126208.51727386143 118861.23402158525 118560.3438653197 131252.06834803018 122543.28902528495 123473.24426721444 135100.34577596356 114307.52194308396 0.9748243421361771 0.9613337071561375 1.1041138424530208 1.0398373790376514 1.0372050924553617 1.1482364949997188 1.0720492137542947 1.0801847697187792 1.181902498448289 1.0 16.802560816859952 -4.9358659352758885 0.7995575824053452 1.093868691777868 0.8953076938032447 0.37582287481389864 0.05396709861141899 2.126740174674079 1.214510424720485 0.02055942869891429 0.3611168850716438 1.1591351206527181e-05 4.9358659352758885 -0.19856099797462323 IDVPPTANT(ph)PTPVR ddPTM_A459_Selumetinib_30min_R1 2 IDVPPTANTPTPVR 14 0 E7EUN2;A0A087X1U1;F5GXM9;Q9UPQ3-2;Q9UPQ3;A0A087X044;Q9UPQ3-3 E7EUN2 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 1 IDVPPT(0.005)ANT(0.969)PT(0.027)PVR;IDVPPT(0.299)ANT(0.666)PT(0.036)PVR 164.93 0.00060068 7975600.0 2648.91 2908.3 2884.6000000000004 2789.75 2837.8 2490.6800000000003 2835.2 2382.1 1497.08 2694.0 True False 2710.6244491183857 2567.7948839680107 2492.887163973603 2302.57253259325 2581.1214910542817 2465.6260205564995 2621.338581367385 2318.9189698487053 2540.4354176029724 3039.8011417821867 0.8917111096054099 0.8447246264479503 0.8200823171321211 0.757474724561518 0.8491086655560013 0.8111142491087238 0.8623388370169952 0.7628521938409301 0.8357242132337498 1.0 11.569761232953171 -11.471374663097267 6.568333804250224 1.0808030814666865 0.8239143653876835 0.635194253269521 0.03949869999978919 0.027260154026988656 0.00021375414170165947 0.022306388908462434 0.009220291937138178 3.377733155787969e-12 11.471374663097267 -0.256888716079003 IDVPQDLEDDLTATPLSHATVPQS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 IDVPQDLEDDLTATPLSHATVPQSPAR 27 0 E7EUC4;Q9NRH2 E7EUC4 SNRK SNF-related serine/threonine-protein kinase 1 IDVPQDLEDDLTATPLS(0.007)HAT(0.318)VPQS(0.675)PAR;IDVPQDLEDDLTATPLS(0.102)HAT(0.218)VPQS(0.681)PAR 198.15 4.8367e-40 13276800.0 2300.92 2721.9 1990.48 2348.24 2768.8 2118.99 2720.8 2296.6 873.5 1621.32 True False 2354.526959189052 2403.218682623022 1720.1837489240027 1938.163965924105 2518.3625288713442 2097.674884488983 2515.5678654713533 2235.6867075918467 1482.2657020841878 1829.4322149941718 1.2870260728389726 1.3136418299219017 0.9402828565197661 1.059434697847102 1.376581492460144 1.1466261866912986 1.375053880025485 1.222065889770597 0.8102326448257663 1.0 10.837180245896086 -8.251208183492379 24.18926083601738 0.9051163253113274 1.2124586721147257 0.4483305313339654 0.1375135999352421 375.4586814176409 887691.6715617289 0.09914151304209133 0.036464854425050465 5.607790964092592e-09 8.251208183492379 0.30734234680339834 IDYLLPGPGPAHS(ph)PQPSKR ddPTM_A459_Selumetinib_30min_R2 1 IDYLLPGPGPAHSPQPSKR 19 1 Q8TDM6-4;Q8TDM6;A0A0J9YYG8;Q8TDM6-3 Q8TDM6-4 DLG5 Disks large homolog 5 1 IDYLLPGPGPAHS(0.865)PQPS(0.135)KR 61.361 0.024638 6452900.0 53319.0 39684.0 48222.0 46904.0 41845.0 38043.0 41664.0 34656.0 31857.0 43145.0 True False 50355.743432868374 42727.63519582839 45119.449020143795 40515.59428608693 36588.05700095362 43283.07793002999 43601.458555649755 34756.84322239033 38229.29015895116 41899.29174582746 1.2018280341906507 1.019769867591698 1.0768546946771962 0.9669756360528857 0.8732380781734154 1.0330264815118344 1.0406251929065555 0.8295329532831921 0.9124089827307934 1.0 15.354638236757646 -1.5228787452825598 0.5448978390841585 0.9408856898725563 11.636940581945655 0.5307565008149542 0.06967445394100787 108.73011215167422 1.0120580076113588 0.0363553291843409 1358.3840640099697 0.02999999999984649 1.5228787452825598 10.696054892073098 IECDDKGDGSCDVR ddPTM_A459_Selumetinib_30min_R1 2 IECDDKGDGSCDVR 14 1 P21333-2;P21333;Q60FE5;A0A087WWY3;Q14315-2;Q14315 P21333-2;Q14315-2 FLNA;FLNC Filamin-A;Filamin-C 0 ; 201.38 0.0028016 39041500.0 8096.42 8712.24 9264.17 10507.37 8637.199999999999 7790.46 8032.14 8236.75 5168.35 6886.09 False True 8285.050833109117 7692.206890589506 8006.146598443222 8672.455077262963 7855.966785021513 7712.095045571729 7426.26921308699 8018.284633265328 8770.31246865118 7769.986727696703 1.0662889298866405 0.9899897078549766 1.0303938576760638 1.1161479911348295 1.0110656633451287 0.9925493203329917 0.9557634360706813 1.0319560269882506 1.128742271513636 1.0 12.923696418957556 IECDDKGDGSCDVR ddPTM_A459_Selumetinib_30min_R2 2 IECDDKGDGSCDVR 14 1 P21333-2;P21333;Q60FE5;A0A087WWY3;Q14315-2;Q14315 P21333-2;Q14315-2 FLNA;FLNC Filamin-A;Filamin-C 0 ; 104.81 0.017027 114396000.0 205098.0 189738.0 206368.0 205636.0 215055.0 144992.0 163439.0 160349.0 128598.0 171587.0 False True 193699.47423234553 204290.2944961721 193090.50755648973 177628.0220581142 188037.86828390678 164963.3318936705 171039.2373482345 160815.58904279422 154321.1933283363 166632.83747343405 1.1624327903749863 1.2259906126170463 1.1587782485386398 1.0659845007226327 1.1284562582923388 0.9899809328996769 1.026443766676559 0.9650894234363184 0.9261151383378406 1.0 17.346313207624377 -6.381740399247769 0.6807715449504763 0.9583179720498831 1.2083585990205348 0.8282105945104327 0.03906712332409183 0.29895135186225513 0.3035497051357873 0.025404880570350907 0.04047352091324057 4.1520215673250165e-07 6.381740399247769 0.25004062697065166 IECSHIR ddPTM_A459_Selumetinib_30min_R2 1 IECSHIR 7 0 D6RC60;D6RIC3;A0A0C4DGU5;A0A087X2G6;Q9Y3C1;Q9Y3C1-3;Q9Y3C1-2 D6RC60 NOP16 Nucleolar protein 16 0 120.62 0.018378 0.0 8630.4 7730.8 9323.3 9178.8 10370.0 6995.1 7471.7 7342.3 6511.5 8796.0 False True 8150.756918228531 8323.727501560072 8723.449028441517 7928.631605686822 9067.227891023751 7958.611529804498 7819.148854892675 7363.664877416799 7813.981946511296 8542.036625247389 0.954193628032176 0.9744429656222653 1.0212376054040713 0.928189839675055 1.0614831437533379 0.9316995324372079 0.9153729020292304 0.8620502580909429 0.9147680218808466 1.0 13.060364368424102 -6.9808515224198535 24.825579052264466 0.9132639997845349 0.9867847495567461 0.30878072239991217 0.04644071951577029 232.4192480259259 301325.35391064273 0.015594291482588169 0.013750731203642123 1.045077451595451e-07 6.9808515224198535 0.07352074977221124 IEDFLER ddPTM_A459_Selumetinib_30min_R1 1 IEDFLER 7 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 157.21 0.017556 7080300.0 4586.3 6459.2 5621.5 6143.8 5618.1 5333.7 5670.0 4667.6 2454.3 4902.4 False True 4693.1518666136835 5702.953861199388 4858.131176689177 5070.900663409414 5109.943846956116 5280.047820612127 5242.307335056812 4543.800085498432 4164.767845020289 5531.670793419825 0.8484148898008179 1.030964074721025 0.8782393888060269 0.9167032625009938 0.9237613802026375 0.9545123015803806 0.947689681984108 0.8214154918444333 0.7528951017790991 1.0 12.433499584528464 -7.760586195968506 24.999050800906375 0.8403664592825933 0.9309629029334519 0.1486232191680178 0.0736050190190036 31.546606431456475 924442.5042307687 0.034653259336400316 0.018505254962688986 1.73545678641483e-08 7.760586195968506 0.0905964436508585 IEDPVY(ph)GIYYVDHINR ddPTM_A459_Selumetinib_30min_R1 2 IEDPVYGIYYVDHINR 16 0 A0A087WT53;Q96QZ7-7;Q96QZ7-6;Q96QZ7-2;Q96QZ7;A0A087WXD2;H7C5T8;H7C4U7;H7C535;Q96QZ7-4;Q96QZ7-3;Q96QZ7-5;H7C4S7 A0A087WT53 MAGI1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 1 IEDPVY(1)GIYYVDHINR;IEDPVY(1)GIYYVDHINR 203.2 2.5294e-06 6343200.0 3361.7 4333.1 3551.5 4162.799999999999 3978.1000000000004 3465.0 3840.6 3870.6 1988.9899999999998 3881.9 True False 3440.021069270484 3825.7786375964592 3069.225806993084 3435.845125433886 3618.281557390598 3430.1452459682787 3550.900449915203 3767.9391145192885 3375.1707599180613 4380.179677908049 0.7853607208445432 0.8734296122353664 0.7007077409342556 0.7844073481192964 0.8260577929348029 0.7831060591574861 0.8106746094970914 0.8602247833629594 0.7705553214954016 1.0 12.096774336020529 -14.52287874250301 0.3084851947777586 2.7530661723672254 0.7913159411370441 0.6291942447555112 0.0461737082194775 187.27943985039602 1.702036809507323 213.11645131449495 0.04333289200838327 3.000000019185095e-15 14.52287874250301 -1.9617502312301813 IEDS(ph)EPHIPLIDDTDAEDDAPTKR ddPTM_A459_Selumetinib_30min_R1 3 IEDSEPHIPLIDDTDAEDDAPTKR 24 1 P20020-6;P20020;P20020-4;P20020-1;A0A0U1RQU3;E7ERY9;H0YHH6 P20020-6 ATP2B1 Plasma membrane calcium-transporting ATPase 1;Calcium-transporting ATPase 1 IEDS(1)EPHIPLIDDTDAEDDAPTKR;IEDS(0.997)EPHIPLIDDT(0.003)DAEDDAPTKR;IEDS(1)EPHIPLIDDTDAEDDAPTKR 173.03 1.8988e-16 27872700.0 6868.12 4923.6 8486.4 5860.75 7694.799999999999 5303.8 6879.900000000001 8670.300000000001 3076.9700000000003 6560.63 True False 7028.133832964869 4347.142623080462 7333.993492458431 4837.280032402867 6998.80669862728 5250.4485874650945 6360.943603960737 8440.335478896455 5221.393357002844 7402.750766447835 0.9493949012600995 0.5872334163650915 0.9907119290978917 0.653443589419127 0.9454332476447285 0.7092564309016296 0.8592675621055654 1.1401620485659683 0.7053315073996875 1.0 12.853845741849184 -7.5316027380754305 24.97693350122798 0.953591039099088 0.8021569337405977 0.1379381692628091 0.15915203935630948 349.2018432492393 999754.7769005371 0.06792269608333831 0.03929183402357041 2.9403380358069633e-08 7.5316027380754305 -0.15143410535849033 IEDS(ph)EPHIPLIDDTDAEDDAPTKR ddPTM_A459_Selumetinib_30min_R2 2 IEDSEPHIPLIDDTDAEDDAPTKR 24 1 P20020-6;P20020;P20020-4;P20020-1;A0A0U1RQU3;E7ERY9;H0YHH6 P20020-6 ATP2B1 Plasma membrane calcium-transporting ATPase 1;Calcium-transporting ATPase 1 IEDS(1)EPHIPLIDDTDAEDDAPTKR;IEDS(1)EPHIPLIDDTDAEDDAPTKR 122.51 1.0252e-07 15607200.0 143333.0 53763.0 89325.0 103133.0 58988.0 52523.0 151010.0 103357.0 72825.0 64297.0 True False 135367.12566746038 57886.449224708194 83577.92674970646 89086.1074856518 51577.40008058912 59757.56649367722 158032.26422063846 103657.75175832746 87392.03490051217 62440.57854633141 2.167935160418427 0.9270645880027518 1.338519416306993 1.4267341776718034 0.8260237377896534 0.9570309546273122 2.530922485021135 1.6601023592600537 1.3996032217361116 1.0 15.930196284290902 IEDVGS(ph)DEEDDSGK ddPTM_A459_Selumetinib_30min_R1 17 IEDVGSDEEDDSGK 14 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(0.999)DEEDDS(0.001)GK;IEDVGS(0.991)DEEDDS(0.009)GK;IEDVGS(1)DEEDDSGK;IEDVGS(0.998)DEEDDS(0.002)GK;IEDVGS(0.703)DEEDDS(0.297)GK;IEDVGS(0.94)DEEDDS(0.06)GK;IEDVGS(0.993)DEEDDS(0.007)GK;IEDVGS(1)DEEDDSGK;IEDVGS(0.996)DEEDDS(0.004)GK;IEDVGS(0.887)DEEDDS(0.113)GK;IEDVGS(0.957)DEEDDS(0.043)GK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(0.972)DEEDDS(0.028)GK;IEDVGS(0.831)DEEDDS(0.169)GK 261.17 1.3578999999999997e-39 5545302000.0 59204.14 77819.9 35006.869999999995 33576.19 40881.7 47152.07 59717.44000000001 59556.57000000001 35677.59 66669.34 True False 60583.48127079735 68708.70993050998 30253.129332972552 27712.73871964591 37183.95745325038 46677.762986454145 55212.90542201321 57976.93629659644 60542.2644419253 75226.9992033647 0.8053422562691775 0.9133517308694779 0.40215786424216976 0.3683881985605827 0.4942900533986373 0.6204921568155064 0.7339506561035827 0.7706931940733758 0.8047943568539606 1.0 16.198962922117758 -8.152408610935273 0.9584673775389525 0.9769653185388386 0.5941174176714913 0.3761721540929921 0.15998905388352985 0.634271585305603 1.158897751144173 0.17029671432004298 0.06150047064320508 7.040303622321008e-09 8.152408610935273 -0.3828479008673473 IEDVGS(ph)DEEDDSGK ddPTM_A459_Selumetinib_30min_R2 20 IEDVGSDEEDDSGK 14 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(0.995)DEEDDS(0.005)GK;IEDVGS(0.608)DEEDDS(0.392)GK;IEDVGS(1)DEEDDSGK;IEDVGS(0.999)DEEDDS(0.001)GK;IEDVGS(0.998)DEEDDS(0.002)GK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(1)DEEDDSGK;IEDVGS(0.99)DEEDDS(0.01)GK 220.25 7.984799999999999e-09 7273117400.0 1329302.4 1028942.9 1127441.0 1228984.0 1187232.0 1116711.9 1502936.3 1505461.7 1179108.7999999998 1050647.0 True False 1255425.0942271273 1107859.5118571129 1054902.6735249483 1061594.2590843476 1038081.3021712557 1270528.8277236752 1572825.8159617817 1509842.3443044005 1414963.5070525391 1020312.09120126 1.2304324383229233 1.0858045507946292 1.0339019625681034 1.040460333891059 1.0174154664276056 1.245235490866156 1.5415144341865263 1.4797848200806816 1.3867948045059801 1.0 19.96057907795246 -6.9789566377733205 4.929855766904096 1.3934107037972052 1.079177263662697 0.4217436339429669 0.14663110826186496 0.15158183005748552 9.840786486075409 0.052046947914617836 0.04417139859481641 1.0496472256752543e-07 6.9789566377733205 -0.31423344013450816 IEDVGS(ph)DEEDDSGKDK ddPTM_A459_Selumetinib_30min_R1 14 IEDVGSDEEDDSGKDK 16 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(0.996)DEEDDS(0.004)GKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(0.998)DEEDDS(0.002)GKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK 259.96 2.187e-38 21763190200.0 63237.799999999996 103241.21999999999 60300.240000000005 61220.45999999999 50042.62999999999 61521.479999999996 68053.01000000001 71479.37999999999 46435.99 79147.09 True False 64711.11770066124 91153.68996685886 52111.79861350885 50529.45591136261 45516.282952243906 60902.629768234474 62919.716665907385 69583.51464465143 78798.48347947831 89306.38995944225 0.7245967251620993 1.0206849701153025 0.5835170208668717 0.565798885547945 0.5096643473430595 0.6819515355608137 0.7045376785970393 0.7791549370235679 0.8823386939642727 1.0 16.446475784828593 -8.288599084210652 1.4252126193647552 0.9951329847035432 0.6801389108269661 0.39388564013638905 0.13042618512932347 0.4547438182702823 1.816630694911471 0.13561512572595671 0.0417690393534078 5.1451840633667935e-09 8.288599084210652 -0.3149940738765771 IEDVGS(ph)DEEDDSGKDK ddPTM_A459_Selumetinib_30min_R2 18 IEDVGSDEEDDSGKDK 16 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(0.999)DEEDDS(0.001)GKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(0.998)DEEDDS(0.002)GKDK;IEDVGS(1)DEEDDSGKDK;IEDVGS(0.799)DEEDDS(0.201)GKDK;IEDVGS(1)DEEDDSGKDK 295.71 1.1183999999999996e-74 9414084300.0 1682513.6 1521714.0 1382367.2 1391815.0 1271848.0 1135870.4 1587646.7 1478042.4 986191.0 1267220.0 True False 1589006.2297475883 1638424.5707182926 1293427.1993596086 1202247.3959852033 1112067.0837746183 1292326.2371951286 1661475.4174122538 1482343.2586809082 1183456.7564788305 1230632.065967027 1.2912114625413664 1.3313683399195546 1.051026732627219 0.9769348851157075 0.9036552146890137 1.0501321011651215 1.3500992403498533 1.2045381391196623 0.96166578883094 1.0 20.230968059051875 -5.261498314416536 24.999998902276776 1.0706969917314435 1.3112899206736912 0.3948958800559462 0.12295338621298302 5.768524138276966 2448415.9234414236 0.03575229313471855 0.08307641473936427 5.47648226489714e-06 5.261498314416536 0.2405929289422477 IEDVGS(ph)DEEDDSGKDKK ddPTM_A459_Selumetinib_30min_R1 7 IEDVGSDEEDDSGKDKK 17 2 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(1)DEEDDSGKDKK;IEDVGS(1)DEEDDSGKDKK;IEDVGS(1)DEEDDSGKDKK;IEDVGS(1)DEEDDSGKDKK;IEDVGS(0.985)DEEDDS(0.015)GKDKK;IEDVGS(0.995)DEEDDS(0.005)GKDKK;IEDVGS(0.998)DEEDDS(0.002)GKDKK 91.926 0.0092304 18982746000.0 47874.0 67871.29999999999 51281.5 48344.4 38619.700000000004 50244.0 47915.2 54156.7 38319.5 60429.5 True False 48989.371053412 59924.89664348869 44317.753969116115 39901.95807678147 35126.55495386182 49738.59097790196 44300.917887251184 52720.28839024618 65025.39275445339 68186.21495817625 0.7184644445136142 0.8788418110646726 0.6499518120532066 0.5851909818026466 0.5151562522631237 0.7294522948430322 0.6497048987749837 0.7731810369967524 0.9536442636438812 1.0 16.057192482117706 -8.183424604599256 2.266623100154209 0.9995082270459723 0.6742421619719181 0.6354532933066397 0.09050458524561575 0.21868138201629242 2.0057610240442982 0.0907216489702954 0.02722706464828295 6.555040742990058e-09 8.183424604599256 -0.3252660650740542 IEDVGS(ph)DEEDDSGKDKK ddPTM_A459_Selumetinib_30min_R2 2 IEDVGSDEEDDSGKDKK 17 2 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(0.982)DEEDDS(0.018)GKDKK;IEDVGS(0.959)DEEDDS(0.041)GKDKK 88.486 0.011364 1694420000.0 265052.0 332470.0 227987.0 251100.0 168137.0 164804.0 217249.0 177150.0 109275.0 207476.0 True False 250321.47092722333 357969.37994045566 213318.56463347698 216899.7468283391 147014.12689614858 187504.25505824087 227351.50897072675 177665.47717123877 131133.0533986057 201485.6287926132 1.2423787861558915 1.7766496900327784 1.0587284359275235 1.076502319932661 0.7296506841560819 0.9306085807799067 1.1283758069154253 0.8817774162647986 0.6508308020994362 1.0 17.620317414882244 -5.436487919726515 4.5735736385076935 0.9196338366582363 1.5068433037895412 0.6235732953496513 0.18189083873564818 0.13371175136057084 4.850806991476153 0.047807324947798484 0.10254754808139559 3.660261217469466e-06 5.436487919726515 0.587209467131305 IEDVGSDEEDDS(ph)GK ddPTM_A459_Selumetinib_30min_R2 1 IEDVGSDEEDDSGK 14 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(0.29)DEEDDS(0.71)GK 215.93 1.3934e-08 4568700000.0 272370.0 187440.0 206670.0 248460.0 212850.0 215260.0 305520.0 287640.0 246770.0 184410.0 True False 257232.7657834984 201816.04528540614 193373.07720528185 214619.31938259315 186109.88009685682 244910.11106427584 319727.28537639463 288476.98477863474 296130.8953298927 179085.60414527837 1.4363676355293487 1.1269250046569255 1.0797801315644173 1.1984174853523626 1.0392230072601492 1.3675588958317337 1.7853321427054767 1.610832909520832 1.6535717471163371 1.0 17.450289844910053 -6.998988051689745 6.988676036903201 1.5658540652801796 1.1716850107689203 0.33595090097114455 0.2183898851324517 0.12567445912406666 36.27393445934332 0.07549571002789285 0.06352506860483635 1.0023328138800235e-07 6.998988051689745 -0.3941690545112593 IEDVGSDEEDDS(ph)GKDKK ddPTM_A459_Selumetinib_30min_R1 1 IEDVGSDEEDDSGKDKK 17 2 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 IEDVGS(0.076)DEEDDS(0.924)GKDKK 53.94600000000001 0.032891000000000004 3659300000.0 8509.6 19316.0 8858.5 10335.0 7498.3 9991.7 9371.1 9966.6 7281.7 13181.0 True False 8707.857123200793 17054.473740235215 7655.564356257422 8530.186261977322 6820.0800889323855 9891.192569737734 8664.230382284108 9702.253391920622 12356.51306567422 14872.90974381256 0.5854844326493303 1.146680376200779 0.5147321195465666 0.5735384944110252 0.45855721620106527 0.6650475757679277 0.5825511303118482 0.6523439971762729 0.8308067001357813 1.0 13.860399304162701 -8.49145287445873 2.588377625052352 0.9981889448720235 0.6486917550821714 0.28910653022322785 0.17798876496008778 0.35598814229800096 5.444128865875608 0.1763048784636227 0.047813923805560925 3.2251292609404973e-09 8.49145287445873 -0.3494971897898521 IEDVGSDEEDDSGK ddPTM_A459_Selumetinib_30min_R1 1 IEDVGSDEEDDSGK 14 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 186.76 8.8886e-14 0.0 739.08 729.06 636.44 838.61 715.6 698.3 827.12 893.24 262.15 638.83 False True 756.2991260006628 643.7013162692014 550.0149437146778 692.1625061593426 650.8741063494416 691.2757360056705 764.7296724818681 869.5483735475664 444.84940332154497 720.8300532311492 1.0492058739927976 0.8930001092265573 0.763029983626812 0.9602298115300503 0.9029508459474916 0.9589996045628226 1.0609014830249337 1.2063153716327188 0.6171349284446311 1.0 9.493515351791443 -6.900534153339428 4.309618486552718 0.9908671697896885 0.9069718218931456 0.02390345210071032 0.1533640506675203 0.7087603491536171 23.673141199932903 0.05491528826486666 0.048072661365145396 1.257377969056044e-07 6.900534153339428 -0.08389534789654285 IEDVGSDEEDDSGK ddPTM_A459_Selumetinib_30min_R2 1 IEDVGSDEEDDSGK 14 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 162.22 0.0038403 6371000.0 21870.0 22435.0 21061.0 22838.0 23565.0 16770.0 24461.0 20911.0 17764.0 18191.0 False True 20654.552952546594 24155.692360105062 19705.958189482986 19727.425002252552 20604.55402622708 19079.915277097032 25598.484968551962 20971.847547997582 21317.296367630603 17665.77856410587 1.1691844136727407 1.3673720788726342 1.1154876711475625 1.1167028348433865 1.1663541434903044 1.0800494984050388 1.4490436906394901 1.1871453880107574 1.206700077795838 1.0 14.108669712464556 -5.276606848715702 24.941154140691445 1.1772766268138934 1.2682782681975864 0.09973086494231287 0.11956008174365028 1764.3663538269927 2901296.406365654 0.031310094839873494 0.06562046188055996 5.2892385098569305e-06 5.276606848715702 0.09100164138369293 IEDVGSDEEDDSGKDK ddPTM_A459_Selumetinib_30min_R1 3 IEDVGSDEEDDSGKDK 16 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 ;; 188.0 2.1822e-06 58336000.0 13278.0 15000.9 13124.099999999999 11475.699999999999 9644.6 13489.8 13359.0 14959.400000000001 8945.1 15008.5 False True 13587.351565509547 13244.587654270792 11341.919305521022 9471.684420568276 8772.247632892428 13354.104859758405 12351.319874607401 14562.62811702058 15179.181375745009 16934.98717016999 0.8023242904749813 0.7820843040023305 0.6697329730192629 0.5592968170210431 0.5179955287090054 0.7885512238994132 0.7293374214279622 0.8599137377955512 0.8963208075222088 1.0 14.047719273406075 -7.95062901042526 1.1418510915011595 0.982043342543435 0.6744292516217839 0.6010005136725247 0.08870181245681917 0.3709056007154777 0.8764962505951205 0.08965973851315291 0.03224118977355887 1.1203945551127433e-08 7.95062901042526 -0.30761409092165104 IEDVGSDEEDDSGKDKK ddPTM_A459_Selumetinib_30min_R1 6 IEDVGSDEEDDSGKDKK 17 2 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 ;;;;; 140.27 0.00075879 216966400.0 32053.299999999996 34087.7 32422.1 32627.5 26167.199999999997 31236.200000000004 30805.799999999996 36310.899999999994 22869.899999999998 38173.7 False True 32800.079525135385 30096.696237058215 28019.356901847234 26929.719619029045 23800.381380194376 30921.992188200384 28482.09370410814 35347.81697757417 38808.54994859206 43073.666238326194 0.7614879899856412 0.6987261328193768 0.650498537710173 0.6252014739127884 0.5525506291595215 0.7178862374312251 0.6612414542685311 0.8206363670553379 0.9009808854873118 1.0 15.394518504121704 -8.120344318730318 1.4142472263041361 0.9912517139386636 0.6589077398732547 0.8161814215785861 0.05510428772822242 0.1722553478343532 0.627154390938562 0.05348099960669044 0.017201911774190302 7.579763954931827e-09 8.120344318730318 -0.33234397406540894 IEDVTPIPSDS(ph)TR ddPTM_A459_Selumetinib_30min_R1 1 IEDVTPIPSDSTR 13 0 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 1 IEDVTPIPSDS(0.592)T(0.408)R 217.12 1.9074e-08 10531000.0 1258.5 4057.2 2917.5 4289.7 3181.5 2172.0 1862.8 1671.8 811.02 1453.0 True False 1287.8206013852825 3582.181137858893 2521.319524680367 3540.5844226419094 2893.733886739447 2150.1516520182117 1722.2874962511155 1627.4584332282714 1376.2417054428356 1639.5067034185304 0.785492733088588 2.184913992964895 1.5378525256549251 2.1595425107195036 1.7650027784001927 1.3114625561060147 1.050491280493077 0.9926512833615518 0.8394242625377732 1.0 10.67904608512371 -7.021557219584068 2.4218096757107244 0.9625602033239433 1.731781681540842 0.45451069343470696 0.36773881929542385 0.2566983527360516 3.008688496868069 0.14981932426678715 0.11724729293291122 9.515744670995255e-08 7.021557219584068 0.7692214782168987 IEDVTPIPSDS(ph)TR ddPTM_A459_Selumetinib_30min_R2 2 IEDVTPIPSDSTR 13 0 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 1 IEDVTPIPSDS(0.916)T(0.083)R;IEDVTPIPSDS(0.989)T(0.011)R 239.38 9.6992e-18 34151000.0 182737.0 207551.0 261660.0 187923.0 231380.0 88474.0 115421.0 123642.0 97174.0 235110.0 True False 172581.20909417036 223469.49431834908 244825.08047386687 162327.56321474336 202311.97583655533 100660.4904129925 120788.30520237275 124001.77774996505 116611.51526841575 228321.7634108583 0.7558684135756939 0.978748109597517 1.0722809635685555 0.7109596596914841 0.8860827492493604 0.44087120259253126 0.5290266832120499 0.5431009987726291 0.5107332456020707 1.0 17.800708856857327 -6.745783103285098 24.67302811055652 0.5714577745026154 0.8874339165685656 0.3827211761570274 0.17261358261538312 187.2184180139283 295040.3834946895 0.054883714253608475 0.05469546597784783 1.7956301822019192e-07 6.745783103285098 0.31597614206595026 IEDVTPIPSDS(ph)TRR ddPTM_A459_Selumetinib_30min_R1 3 IEDVTPIPSDSTRR 14 1 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 1 IEDVTPIPS(0.001)DS(0.778)T(0.221)RR;IEDVTPIPS(0.004)DS(0.964)T(0.032)RR;IEDVTPIPS(0.002)DS(0.499)T(0.499)RR 133.28 0.0003796 32839000.0 8419.3 25298.5 17306.0 27700.5 18241.1 10458.1 10100.3 7082.000000000001 4127.2 7254.099999999999 True False 8615.453308894002 22336.539859046417 14955.940255053443 22863.127677784494 16591.19572572778 10352.901009195059 9338.426239201815 6894.162354421956 7003.556961238536 8185.234395917657 1.0525603656739402 2.7288821283098077 1.8271853354025684 2.793215999921439 2.026966476855269 1.264826455594053 1.1408868442251705 0.8422681649606006 0.8556330365727246 1.0 12.99880801559317 -6.845552368209819 2.779989070752244 0.9625842949558211 2.159805148850734 0.5772348827432395 0.46073937886886424 0.1837570265877926 2.8810396947773813 0.16919345831507118 0.14952382963974692 1.4270777395315694e-07 6.845552368209819 1.1972208538949127 IEDVTPIPSDS(ph)TRR ddPTM_A459_Selumetinib_30min_R2 5 IEDVTPIPSDSTRR 14 1 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 1 IEDVTPIPS(0.001)DS(0.5)T(0.5)RR;IEDVTPIPS(0.007)DS(0.796)T(0.197)RR;IEDVTPIPS(0.008)DS(0.496)T(0.496)RR;IEDVTPIPS(0.007)DS(0.795)T(0.198)RR;IEDVTPIPS(0.011)DS(0.811)T(0.178)RR 128.74 0.00056985 45711600.0 212201.0 246835.0 321349.0 243178.0 257021.0 90127.0 109269.0 157310.0 116498.0 277831.0 True False 200407.71792790768 265766.4508003799 300673.7551983362 210056.7368945521 224731.72418310682 102541.17615855244 114350.22501241577 157767.74605592765 139800.85522608837 269809.297138371 0.7427754345512012 0.9850159116795827 1.1143936046211798 0.7785378010411 0.8329280220016057 0.38005056625593026 0.42381869796640687 0.5847379898662902 0.5181469160211772 1.0 18.041580536230505 -6.615667092762656 5.561338574439756 0.5465912669729809 0.9120809201233409 0.4070428174963292 0.18555088743544437 0.18441586327226703 8.87760101257575 0.06061081033827951 0.060559976558018445 2.422885591348562e-07 6.615667092762656 0.36548965315035997 IEDVTPIPSDST(ph)R ddPTM_A459_Selumetinib_30min_R1 1 IEDVTPIPSDSTR 13 0 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 1 IEDVTPIPSDS(0.07)T(0.93)R 234.83 2.2847e-13 11008000.0 1174.1 3043.6 2236.4 3297.5 2236.1 1728.1 1890.9 1725.9 721.3 1141.5 True False 1201.4542455990932 2687.253897068747 1932.7091636658686 2721.6535267411937 2033.8451498155207 1710.7168829892582 1748.2678906276767 1680.1235254867063 1223.9934183323692 1288.0226441515845 0.9327896920558306 2.0863405696091863 1.5005242123976295 2.113047887084265 1.5790445603192067 1.3281729872972077 1.357326983780828 1.3044207981245526 0.950288742119599 1.0 10.33094224171557 -7.515228150480353 0.9336312150633189 0.9986967470804616 1.6772462861521997 0.3642810384912908 0.3205181058082534 0.6043707353513196 0.9747290499059408 0.2584048339892534 0.12385705232450347 3.053316674969685e-08 7.515228150480353 0.6785495390717381 IEDVTPIPSDSTR ddPTM_A459_Selumetinib_30min_R2 1 IEDVTPIPSDSTR 13 0 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 0 144.17 0.0094664 5042900.0 28749.0 25374.0 26390.0 20726.0 24715.0 23651.0 19329.0 20158.0 19750.0 28027.0 False True 27151.24567136543 27320.104209730598 24692.09613125949 17903.083045655756 21610.080745096628 26908.71056759821 20227.83679968689 20216.656442663465 23700.551861106967 27217.78768710875 0.9975552011607894 1.0037591785121576 0.9072043773401351 0.6577714269604378 0.7939690394209329 0.9886442967715215 0.7431844583484449 0.7427736844401481 0.8707743676144677 1.0 14.732262186194921 -5.524627865998127 24.998520347432503 0.8163422672658203 0.989363367107663 0.3111100780069943 0.10152094628617461 59.33817390647105 848061.4189164789 0.0274720319602788 0.04801227551406717 2.987941800622248e-06 5.524627865998127 0.17302109984184277 IEDVTPIPSDSTRR ddPTM_A459_Selumetinib_30min_R1 2 IEDVTPIPSDSTRR 14 1 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 0 ; 123.28 0.0022349 10806100.0 6733.0 6394.0 11228.9 12429.7 10007.5 8346.9 6918.1 7532.299999999999 4687.9 5655.8 False True 6889.8657998626195 5645.387507510046 9704.077055932607 10259.086229366187 9102.323391967628 8262.937764378825 6396.262147205738 7332.518935641412 7955.023909330808 6381.777022157273 1.0796155641197245 0.8846105854074011 1.5205916819469627 1.6075594922459766 1.426299189138813 1.2947706784004263 1.0022697635781026 1.1489776139440788 1.2465217574527103 1.0 12.639742486722161 -7.161192928179625 7.257925806940085 1.1123737065889756 1.3139540435289958 0.18649746501935915 0.20615739971639357 0.5445861690648328 34.45401835547525 0.08925530219532482 0.06903710938995321 6.899332442586053e-08 7.161192928179625 0.2015803369400202 IEDVTPIPSDSTRR ddPTM_A459_Selumetinib_30min_R2 2 IEDVTPIPSDSTRR 14 1 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 0 ; 128.21 0.0015598 15875600.0 74748.0 90021.0 87829.0 96908.0 91399.0 62513.0 53289.0 51027.0 44142.0 87509.0 False True 70593.80539995208 96925.32123686308 82178.17776098497 83708.96322437568 79916.6405025728 71123.59831348633 55767.04409015029 51175.480122025394 52971.63343053086 84982.38779431263 0.8306874781020981 1.140534218354238 0.967002456554706 0.9850154296320893 0.9403906218309526 0.8369216276392533 0.656218841780796 0.6021892470930343 0.6233248418335916 1.0 16.37487625992243 -6.934134089185888 2.261705742434809 0.6879148045583646 0.9875039126937702 0.4601990425917739 0.1266624713114491 0.23191979235627072 2.4062899908839164 0.05013000200558243 0.04131896533536957 1.1637666589303885e-07 6.934134089185888 0.2995891081354056 IEEAMDGSET(ph)PQLFTVLPEKR ddPTM_A459_Selumetinib_30min_R1 1 IEEAMDGSETPQLFTVLPEKR 21 1 E9PPJ0;Q13435 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 IEEAMDGS(0.004)ET(0.996)PQLFTVLPEKR 133.15 5.5126e-05 81806000.0 2553.0 2745.5 3394.4 3182.9 2795.8 2445.4 3365.6 2803.2 1882.5 1851.1 True False 2612.4799327267588 2424.055583651676 2933.459124104554 2627.066265432764 2542.9203836385796 2420.8014962455513 3111.7300823398928 2728.850029923134 3194.4650076399325 2088.706716240908 1.2507643664920545 1.1605533533277965 1.4044380196105108 1.2577477943675852 1.217461678016304 1.1589954096582413 1.4897879430100855 1.3064783144061058 1.5293985425532035 1.0 11.028394216641377 -7.245926049719552 24.945910183991852 1.3569560765445297 1.2450037663853697 0.07091525627014239 0.1477325704978946 1715.382719917142 2758391.936891425 0.05327445999935177 0.0411275883515786 5.676412533236245e-08 7.245926049719552 -0.11195231015915996 IEEAMDGSET(ph)PQLFTVLPEKR ddPTM_A459_Selumetinib_30min_R2 3 IEEAMDGSETPQLFTVLPEKR 21 1 E9PPJ0;Q13435 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 IEEAMDGS(0.192)ET(0.808)PQLFTVLPEKR;IEEAMDGS(0.04)ET(0.959)PQLFTVLPEKR;IEEAMDGS(0.014)ET(0.985)PQLFTVLPEKR 93.712 0.00061934 9368000.0 27923.100000000002 28184.4 24727.2 30694.4 30209.4 23755.8 25481.5 24442.699999999997 21272.3 25937.899999999998 True False 26371.24588702576 30346.052852870307 23136.278872939743 26513.769769206618 26414.2250965374 27027.945816318537 26666.440240634343 24513.82421029318 25527.35439772282 25189.005432242408 1.0469347810481657 1.2047340628235674 0.9185070420972186 1.0525929592785146 1.0486410496671175 1.0730056765846836 1.0586539556857926 0.9731953997244773 1.013432406705797 1.0 14.620506539084944 -1.5228787452803376 0.2502374560388358 1.0042196332084088 1.6122570880050306 0.12308531699530167 0.0664637031793215 103.51226141998357 1.4080175150725922 0.08552909117943927 26.49932632368004 0.029999999999999995 1.5228787452803376 0.6080374547966219 IEEDNLTYQHLLPES(ph)PEPSASHALSDYETSEK ddPTM_A459_Selumetinib_30min_R1 1 IEEDNLTYQHLLPESPEPSASHALSDYETSEK 32 0 Q5JTU8;B1AMJ5;A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8 Q5JTU8 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 IEEDNLTYQHLLPES(0.668)PEPS(0.228)AS(0.08)HALS(0.016)DY(0.007)ET(0.001)SEK 69.7 7.3602e-05 11437000.0 1240.9 1129.8 1591.2 1690.7 1713.2 1367.0 1564.6 1586.3 240.88 961.83 True False 1269.8105556289213 997.5224907702292 1375.1237798359557 1395.450983369624 1558.241362490027 1353.2492211366928 1446.5809623333128 1544.2261709714132 408.75576682088007 1085.2902495175808 1.170019316209061 0.9191296901576652 1.2670562372113892 1.2857859765992663 1.4357830664955078 1.2469007454348933 1.3328977782453386 1.4228692938666248 0.3766326722299172 1.0 10.083865212622737 -8.252295438588975 24.995594903614105 0.6883163181873906 1.2576293334189268 0.5777227322715384 0.1955137314874523 403.4387038769786 1102835.2190816242 0.13600165713416268 0.04980814090428245 5.593769432875914e-09 8.252295438588975 0.5693130152315362 IEEDNLTYQHLLPES(ph)PEPSASHALSDYETSEK ddPTM_A459_Selumetinib_30min_R2 2 IEEDNLTYQHLLPESPEPSASHALSDYETSEK 32 0 Q5JTU8;B1AMJ5;A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8 Q5JTU8 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 IEEDNLTYQHLLPES(0.987)PEPS(0.009)AS(0.003)HALSDYETSEK;IEEDNLTYQHLLPES(0.991)PEPS(0.005)AS(0.002)HALS(0.001)DY(0.001)ET(0.001)SEK 100.38 2.8659e-09 10351400.0 17867.8 20765.2 29575.0 37576.0 37199.0 28538.0 22515.7 21691.0 28091.0 38188.0 True False 16874.77920647059 22357.824069358325 27672.176698825275 32458.083977784452 32525.7290567206 32468.850457829172 23562.72466401315 21754.117218861637 33709.98492811932 37085.413215660206 0.455024704951779 0.6028738021427033 0.7461741504107074 0.8752250861823551 0.8770491208383201 0.8755154019456475 0.635363681321022 0.5865949798740664 0.9089823196006473 1.0 15.17856422355039 -5.071325003065081 2.0125260063624575 0.8023191722077619 0.44300337480863966 0.49734637956666794 0.11936837716874438 0.4038384639524222 2.6500002394390143 0.03469132922200514 0.21513663188200963 8.48545230915857e-06 5.071325003065081 -0.3593157973991223 IEEDRCS(ph)NSADITGPSFIR ddPTM_A459_Selumetinib_30min_R1 1 IEEDRCSNSADITGPSFIR 19 1 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 IEEDRCS(0.995)NS(0.005)ADITGPSFIR 88.04 0.0017722 23648000.0 2423.0 2434.6 1944.7 2017.6 2171.2 2411.4 2560.4 2248.7 1262.2 1809.6 True False 2479.451185662723 2149.555900185166 1680.6204214724619 1665.264035042618 1974.815343356493 2387.143505376021 2367.266966610135 2189.0571711929747 2141.86121255943 2041.879786996677 1.214298315431024 1.052733816101322 0.8230751056821137 0.8155543953407713 0.9671555377220191 1.1690911093679903 1.159356677942367 1.072079358017827 1.0489653828787893 1.0 10.995682216593327 -6.733850765307627 19.614319640073646 1.0987441387977908 0.9616551544618521 0.19261376449175682 0.11587317551256789 32.08105263069831 22806.790112149163 0.041811179539277224 0.041775353882776825 1.8456495226101746e-07 6.733850765307627 -0.13708898433593864 IEEDRCS(ph)NSADITGPSFIR ddPTM_A459_Selumetinib_30min_R2 3 IEEDRCSNSADITGPSFIR 19 1 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 IEEDRCS(0.944)NS(0.056)ADITGPSFIR;IEEDRCS(0.954)NS(0.045)ADITGPSFIR;IEEDRCS(0.966)NS(0.034)ADITGPSFIR 139.39 0.00063212 21150600.0 24349.4 20879.2 30078.199999999997 38493.5 38019.5 25572.9 31522.2 33230.2 30118.0 29218.2 True False 22996.1578263712 22480.567502790534 28143.00135866801 33250.618895008694 33243.15051135752 29095.334847327067 32988.04476005431 33326.89438044426 36142.441567231384 28374.59464799946 0.8104488579184879 0.7922780142473513 0.991838005363443 1.1718447191051948 1.1715815123970876 1.0254008985244982 1.1625908729018661 1.1745328803417447 1.2737606304370446 1.0 14.79231216213809 -5.469921733850425 2.738133168764516 1.1445845271812152 0.798463565358593 0.7642367727605717 0.07484847802117056 0.12356051660552134 1.8113656723594025 0.02095055662788575 0.049358100906308544 3.389052262616702e-06 5.469921733850425 -0.3461209618226222 IEEEEEVEQELLSHS(ph)WGR ddPTM_A459_Selumetinib_30min_R1 4 IEEEEEVEQELLSHSWGR 18 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 IEEEEEVEQELLSHS(1)WGR;IEEEEEVEQELLS(0.397)HS(0.603)WGR;IEEEEEVEQELLS(0.016)HS(0.984)WGR;IEEEEEVEQELLS(0.004)HS(0.996)WGR 252.44 2.5335e-33 19576600.0 2911.39 3235.62 3665.1499999999996 3657.7599999999998 3173.62 3263.85 2894.28 2898.26 1824.6599999999999 2605.79 True False 2979.2197224212146 2856.792106201071 3167.4427612278478 3019.0008806589426 2886.5666313481174 3231.018632338692 2675.9621294018025 2821.3887299247344 3096.31475210639 2940.2685290440277 1.0132474952516841 0.9716092520059393 1.077263090068063 1.0267772656943388 0.9817357165968204 1.0988855611052628 0.910108074472994 0.9595683870554691 1.0530720992048634 1.0 11.521732204291453 -7.265737455011464 24.970935542828336 0.9773178460546533 1.0257245654622535 0.1814713274442954 0.04910642525280764 641.9757221173769 3729727.5344619406 0.019917266183888057 0.013984090639352605 5.423286464393034e-08 7.265737455011464 0.04840671940760022 IEEEEQEPEPPEPFEYIDD ddPTM_A459_Selumetinib_30min_R1 1 IEEEEQEPEPPEPFEYIDD 19 0 A0A087WW66;Q99460-2;Q99460 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 113.07 0.007563200000000002 8735400.0 3277.9 3817.4 3638.2 3971.8 3836.4 3463.4 3931.4 3030.4 1880.1 2831.9 False True 3354.268692316897 3370.4570333388856 3144.152423202093 3278.1996899198402 3489.398297371434 3428.561340515597 3634.851332811701 2950.0239478735243 3190.392382928999 3195.4019500419395 1.0497172952757547 1.0547834313284588 0.9839614772597939 1.0259115257399196 1.0920060611860227 1.0729671553435076 1.1375255412747036 0.9232090341043966 0.9984322576028738 1.0 11.641781704052935 -7.775520482313499 24.99998751911822 0.9706154984613583 1.0569325918553212 0.45711187058697855 0.042674194869653535 233.8006553029233 415090.0194818669 0.024471973340541877 0.011843366372267752 1.676793252508075e-08 7.775520482313499 0.08631709339396287 IEEEEQEPEPPEPFEYIDD ddPTM_A459_Selumetinib_30min_R2 2 IEEEEQEPEPPEPFEYIDD 19 0 A0A087WW66;Q99460-2;Q99460 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 ; 113.07 0.007563200000000002 9230700.0 84518.0 72632.0 90487.0 97523.0 104318.0 72582.0 66105.0 78636.0 65523.0 87053.0 False True 79820.82791236094 78202.64085131069 84665.16493479631 84240.19916344133 91212.64022524751 82579.51166620487 69179.01348457257 78864.81774110944 78629.43086558537 84539.55369914272 0.9441832186200714 0.9250420357033858 1.001485827995977 0.9964590002832671 1.0789344896455546 0.9768150889474387 0.8183035095118332 0.9328747821613964 0.9300904419889635 1.0 16.36733887566865 -7.026579333661156 24.927018299517336 0.9122713898120001 0.9908525136879887 0.2502993668069241 0.056285225982663466 931.171902924204 873282.8231064312 0.02209713183942256 0.017172143099163498 9.40633986374413e-08 7.026579333661156 0.07858112387598859 IEEELGS(ph)K ddPTM_A459_Selumetinib_30min_R1 4 IEEELGSK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 1 IEEELGS(1)K;IEEELGS(1)K;IEEELGS(1)K;IEEELGS(1)K 126.71 0.0047677 63480000.0 13069.0 27790.0 17756.8 17416.9 14216.0 17644.9 20705.8 21029.8 8895.5 17064.300000000003 True False 13373.48227215276 24536.333880779508 15345.524091120598 14375.365370704678 12930.16531003865 17467.40832628737 19143.944835664777 20472.021389582427 15095.013798385678 19254.66912535776 0.6945578854190918 1.2743056617091368 0.7969767743716277 0.7465911399003372 0.671534017326221 0.9071777973729692 0.9942494836461686 1.063223743617669 0.783966408360975 1.0 14.232920711445349 -9.619704085411833 13.38959677164432 0.9999999998038515 0.8897590397987306 0.03676371569633585 0.17754185483272927 0.0 0.0 0.17449536742989025 0.04232134300555302 2.4004679652253315e-10 9.619704085411833 -0.11024096000512085 IEEELGS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 IEEELGSK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 1 IEEELGS(1)K;IEEELGS(1)K 106.16 0.013847 30785000.0 148271.0 127662.0 121369.0 105485.0 116633.0 87330.0 119733.0 115172.0 70631.0 111894.0 True False 140030.69139584055 137453.26490197185 113560.25067657561 91117.76102822527 101980.51982775064 99358.91479719037 125300.82174643857 115507.13145224898 84759.17359503038 108663.32948447386 1.2886655697021372 1.2649461925571828 1.0450650759123061 0.838532754890825 0.9384998629397043 0.9143739223579291 1.1531104590748062 1.0629817068945324 0.7800163495555419 1.0 16.729505631943823 -5.327760379370928 3.449566875219475 0.9627199413194943 1.2844010614490136 0.6139464443935299 0.10025470966266586 0.1606495672888365 3.7417457780694066 0.028179392689374208 0.06992894060191128 4.70153442754377e-06 5.327760379370928 0.3216811201295192 IEEVLSPEGSPS(ph)KSPSKK ddPTM_A459_Selumetinib_30min_R2 1 IEEVLSPEGSPSKSPSKK 18 2 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 IEEVLSPEGS(0.233)PS(0.29)KS(0.29)PS(0.187)KK 55.815 0.025899 26453000.0 82272.0 61568.0 66966.0 64426.0 62800.0 42269.0 73754.0 68843.0 43699.0 50252.0 True False 77699.65160091053 66290.06762767768 62657.480467067944 55651.067658950975 54910.502560876725 48091.1710702215 77183.70714077854 69043.3217324279 52440.021052076656 48801.09418962386 1.5921702759162952 1.3583725678382914 1.2839359753615984 1.1403651615414714 1.1251899874931872 0.9854527212721123 1.581597880589928 1.4147904443320445 1.0745665014868973 1.0 15.574625874965623 -4.78435374999451 1.5955066426496713 1.213580335526218 1.7298123622296613 0.32494148585914506 0.1757633457011972 1.4025221859699257 3.448125639730457 0.052145004820292364 1.139858544746608 1.643032862904182e-05 4.78435374999451 0.5162320267034433 IEEVLSPEGSPSKS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 IEEVLSPEGSPSKSPSK 17 1 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 IEEVLSPEGSPS(0.001)KS(0.988)PS(0.011)K 194.67 4.3119e-07 12538000.0 3138.3 3160.7 2453.6 2777.8 1927.0 2619.5 2775.6 3157.1 1605.5 2870.3 True False 3211.416283931212 2790.6437746304337 2120.4145966600686 2292.7093757639686 1752.7031902394826 2593.1502083157034 2566.2342573516185 3073.3634522939215 2724.4162389194776 3238.730964089611 0.9915662398447853 0.8616472950586274 0.6547053831178921 0.7079036206418696 0.5411697389110421 0.8006686066450176 0.7923579592764886 0.9489406456944862 0.8411986883527066 1.0 11.661212915532381 -7.6092568706410315 2.6468459345256243 0.9237093198373599 0.7480313739903397 0.2849434151260051 0.11930551354582612 0.39952731888356335 5.629716147172787 0.07271671629976505 0.037124121506622004 2.458912809383874e-08 7.6092568706410315 -0.17567794584702023 IEEVLSPEGSPSKS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 IEEVLSPEGSPSKSPSK 17 1 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 IEEVLSPEGSPS(0.072)KS(0.855)PS(0.073)K;IEEVLSPEGS(0.005)PS(0.024)KS(0.954)PS(0.018)K;IEEVLSPEGSPS(0.002)KS(0.997)PS(0.001)K 209.19 1.9954e-08 125547800.0 361317.0 248427.0 252588.0 306041.0 270523.0 223941.0 266894.0 259404.0 185772.0 219334.0 True False 341236.4476065515 267480.5520812935 236336.76307702027 264357.68784982746 236537.4822336951 254786.84001600396 279305.09984042775 260158.82269335582 222931.59090337023 213001.25752182872 1.6020395915811954 1.2557698259311056 1.109555717307444 1.241108578069008 1.1104980552025818 1.1961752854435284 1.3112838069127555 1.2213957124957082 1.0466210082375866 1.0 17.700502422329947 -4.775449759471388 3.2427902507413213 1.1711586069651434 1.6664474986213387 0.6891845890599051 0.08956927054892286 0.19374636863001413 3.110529215202322 0.022247612443597683 0.2469998112234971 1.677066332746564e-05 4.775449759471388 0.4952888916561953 IEEVLSPEGSPSKS(ph)PSKK ddPTM_A459_Selumetinib_30min_R2 2 IEEVLSPEGSPSKSPSKK 18 2 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 IEEVLSPEGS(0.021)PS(0.122)KS(0.752)PS(0.104)KK;IEEVLSPEGS(0.005)PS(0.108)KS(0.829)PS(0.058)KK 105.39 0.001961 19339500.0 51935.0 31981.2 41391.0 42211.8 36932.1 29230.9 40848.3 40736.4 28230.8 34069.4 True False 49048.66061227741 34434.05520423411 38727.94812311335 36462.4800205834 32292.359420836852 33257.19114330923 42747.826889370896 40854.93617972593 33877.74883445768 33085.727899068115 1.4824718610364593 1.0407525356334677 1.1705333562936104 1.1020606870677432 0.9760208244276346 1.0051823929872175 1.292032232743319 1.234820533625819 1.0239384467467578 1.0 15.01392139931343 -4.755616886516008 24.998646021120667 1.1036460251649005 1.4824724721153606 0.5644012161078676 0.10208195072183208 154.17009454907517 661856.9112267621 0.026765622420721672 0.23371821614247232 1.7554283726047212e-05 4.755616886516008 0.3788264469504601 IEEVLSPEGSPSKSPS(ph)KK ddPTM_A459_Selumetinib_30min_R1 1 IEEVLSPEGSPSKSPSKK 18 2 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 IEEVLSPEGSPS(0.325)KS(0.253)PS(0.422)KK 78.413 0.014642 18210000.0 1769.6 2195.6 1900.4 1941.1 1637.4 1600.4 1641.4 2038.5 1077.7 2117.6 True False 1810.8282369578026 1938.5381312932514 1642.33611814998 1602.1233239597664 1489.297459106449 1584.3014290469366 1517.587876501278 1984.4323580188009 1828.7781879062711 2389.414587170735 0.7578543492119437 0.8113025431842873 0.687338282342472 0.6705087231667122 0.6232896823777663 0.6630500364203773 0.6351295771983329 0.8305098531973613 0.7653666290167317 1.0 11.222441482098905 -8.717794104931984 1.076237546012006 0.9970140047446702 0.6965482748580082 0.6593821589097384 0.06387541123209482 0.5103911074725181 1.176694494689994 0.06647788713505048 0.021171148435888704 1.9151636715230296e-09 8.717794104931984 -0.300465729886662 IEEVPELPLVVEDK ddPTM_A459_Selumetinib_30min_R2 2 IEEVPELPLVVEDK 14 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 ; 226.73 5.7535e-12 4093200.0 31336.0 22976.0 25455.0 31904.0 27505.0 32679.0 35398.0 33477.0 28768.0 24770.0 False True 29594.470567946966 24738.18532051589 23817.25301330847 27558.620162530224 24049.576002180173 37180.235619573876 37044.077139806344 33574.41252758429 34522.40384507978 24054.825739811018 1.2302924530842796 1.0284084195036967 0.9901236978778291 1.1456586907183612 0.9997817594819589 1.5456456023308516 1.539985262853015 1.3957454063788224 1.435155017063574 1.0 14.554038727702858 -6.756052137503699 24.999755064568127 1.417832793465876 1.0748325176030968 0.4736716437941624 0.1583594572741521 101.55806940199265 471284.8568329849 0.05044640230316712 0.049043803707146956 1.753669959303758e-07 6.756052137503699 -0.34300027586277926 IEEVPELPLVVEDKVEGYKK ddPTM_A459_Selumetinib_30min_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 107.73 0.00027959 9130500.0 6011.3 5342.6 7017.3 6633.4 6354.6 5831.3 5550.0 5919.1 3789.3 4449.2 False True 6151.3515940463585 4717.085908292646 6064.389203269763 5475.001214339663 5779.827551995754 5772.642416396772 5131.359031669365 5762.106240053512 6430.165340478086 5020.298158877996 1.2252960679572757 0.9396027405166877 1.2079739113792227 1.0905729183948092 1.1512916900711547 1.1498604731649884 1.02212236589872 1.1477617579074837 1.2808333563031218 1.0 12.29355733400963 IEFADLSPS(ph)PSSFEK ddPTM_A459_Selumetinib_30min_R2 1 IEFADLSPSPSSFEK 15 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 IEFADLS(0.007)PS(0.99)PS(0.003)S(0.001)FEK 126.91 0.0011017000000000002 3010700.0 17353.0 13662.0 15589.0 17867.0 16560.0 14797.0 16709.0 20444.0 14198.0 17738.0 True False 16388.589729562922 14709.831469746176 14586.020712019854 15433.48377770586 14479.584751721639 16835.152436207798 17486.001608255378 20503.488655313613 17037.996725265657 17225.85785114121 0.9513946922810107 0.8539389792289301 0.8467514847774931 0.8959486320551168 0.8405726366052864 0.9773186671857085 1.0151019333470777 1.1902738796811365 0.9890942368444596 1.0 14.072288210767546 -7.081715576887307 2.3466780798998004 1.0676380930687166 0.8760554393387708 0.6294741392283806 0.061224541545645925 0.17596492381085094 1.9097000310634518 0.025683916337926174 0.01922615010234627 8.284845675991671e-08 7.081715576887307 -0.19158265372994576 IEGDMIVCAAYAHELPK ddPTM_A459_Selumetinib_30min_R2 1 IEGDMIVCAAYAHELPK 17 0 A0A2R8Y6J3;P46777;Q5T7N0;A0A2R8Y4A2 A0A2R8Y6J3 RPL5 60S ribosomal protein L5 0 91.789 0.026231 0.0 12320.0 11237.0 10255.0 12303.0 11840.0 9779.6 7532.5 10616.0 6731.5 10920.0 False True 11635.30372086758 12098.841767350157 9595.204464799772 10627.310176141222 10352.55334905702 11126.651129630189 7882.776175365591 10646.890802426587 8077.988093824894 10604.711226432628 1.0971825137365516 1.140893090723051 0.9048058226124419 1.002131029240312 0.9762220892213364 1.0492177384233345 0.7433277537739533 1.0039774374891817 0.7617357909464065 1.0 13.372417715376347 -4.565907310019621 0.4519800730994054 0.894233883539149 1.3414678422109947 0.3248566562583943 0.10188170909513092 6.920445494372606 0.9508165495045442 0.06915166053713759 1.7303309643715756 2.71701909101947e-05 4.565907310019621 0.4472339586718457 IEHAPS(ph)PSSGGTLK ddPTM_A459_Selumetinib_30min_R1 1 IEHAPSPSSGGTLK 14 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 IEHAPS(0.979)PS(0.019)S(0.001)GGTLK 82.94200000000002 0.033083 0.0 3730.7 4188.3 3462.7 3174.2 3764.0 3259.8 4267.4 3858.6 1718.2 3985.2 True False 3817.6180513214717 3697.931888912153 2992.484359249599 2619.8855571135377 3423.546864588173 3227.0093716615875 3945.506582296551 3756.2573935007854 2915.65990763715 4496.739239135256 0.8489747455437548 0.8223585340970945 0.6654787391730252 0.5826189640512386 0.7613398692974994 0.7176332004259506 0.8774150273066069 0.8353291560270973 0.6483942591694165 1.0 12.134663510827371 -7.2458971226631625 24.193079284928903 0.8265620406683334 0.7285003682146711 0.18947762086854136 0.10689267791373536 1032.8666668549538 1607762.428101998 0.042134879278724946 0.03250065055807351 5.6767906346879115e-08 7.2458971226631625 -0.09806167245366226 IEHAPS(ph)PSSGGTLK ddPTM_A459_Selumetinib_30min_R2 1 IEHAPSPSSGGTLK 14 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 IEHAPS(0.785)PS(0.098)S(0.098)GGT(0.019)LK 114.64 0.0029134 31808000.0 48693.0 33494.0 32871.0 45975.0 40573.0 32760.0 37590.0 44382.0 32714.0 32323.0 True False 45986.83799352314 36062.882099815426 30756.115647238767 39713.12568870134 35475.85701277788 37272.39263432907 39338.00948317194 44511.144272164376 39257.71410553182 31389.751004760263 1.465027167197001 1.1488744238317303 0.9798139412630127 1.2651621761089737 1.1301732532825113 1.1874064445008405 1.2532118995530204 1.418015207110571 1.2506538869829957 1.0 14.938005964518464 -7.283367628915927 5.520600520195369 1.2660638490536489 1.1840637784292114 0.0 0.1501940221206838 0.5984048199380005 60.41504426660003 0.06194541898359862 0.042881468820847486 5.2075370809802944e-08 7.283367628915927 -0.08200007062443748 IEIPVTPTGQSVPSS(ph)PSIPGTPTLK ddPTM_A459_Selumetinib_30min_R1 1 IEIPVTPTGQSVPSSPSIPGTPTLK 25 0 Q9H4Z3 Q9H4Z3 PCIF1 Phosphorylated CTD-interacting factor 1 1 IEIPVTPTGQSVPS(0.339)S(0.512)PS(0.141)IPGT(0.006)PT(0.002)LK 68.93 0.00096793 7615400.0 2771.8 3143.4 3846.1 4060.3 3493.3 2939.7 3372.5 3291.9 2256.4 2842.6 True False 2836.3775470160717 2775.369266672985 3323.8207451150497 3351.24482627059 3177.3316317922076 2910.1292870340403 3118.109609784673 3204.588118401812 3828.94599906441 3207.4753992687647 0.8843021984401517 0.8652815442655334 1.0362731841599813 1.0448232360674072 0.9906020269139307 0.9072959024712979 0.9721382775049607 0.9990998275878871 1.1937569341723797 1.0 11.647222484820674 -5.257768277059284 24.872217686009275 1.0123545526378677 0.874791855661366 0.403305772970727 0.06940475454947896 309.2064227693518 2094890.3025970208 0.018619299758841027 0.045491896990551 5.5237208530586455e-06 5.257768277059284 -0.1375626969765017 IENHEGVR ddPTM_A459_Selumetinib_30min_R1 3 IENHEGVR 8 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ;; 141.2 0.0032223 67114300.0 17568.3 21306.8 20790.9 15886.999999999998 14869.9 18112.4 12598.0 18777.8 27349.8 14977.6 False True 17977.607208038986 18812.18995073741 17967.609976238924 13112.633685924888 13524.920170494075 17930.205700743394 11647.722717292014 18279.751745109374 46410.61304964177 16900.120854178513 1.0637561330571235 1.1131393741534188 1.0631645851098441 0.7758899358807142 0.8002854113998878 1.060951330197748 0.6892094333403623 1.081634380181947 2.7461704830452063 1.0 14.044745942926767 -8.031234277074416 24.033253408935803 1.886691836602906 0.9386950631579847 0.44369450825497236 0.4134419092239949 336.9868407758416 259292.15431714375 0.25187528085799876 0.09547966365334476 9.306057313872438e-09 8.031234277074416 -0.9479967734449213 IENHEGVR ddPTM_A459_Selumetinib_30min_R2 4 IENHEGVR 8 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ;;; 128.12 0.006195 147701000.0 279559.0 264079.0 214451.0 219770.0 226622.0 223211.0 399840.0 758280.0 359059.0 577569.0 False True 264022.22994334594 284333.0101521814 200653.45613659476 189836.94687560393 198151.71833361476 253956.28914228422 418433.3522679293 760486.4692599879 430880.83294669475 560893.0822655191 0.47071757219205895 0.5069290728345657 0.35773922424953025 0.33845478376882127 0.35327894851770064 0.4527712984380592 0.7460126813791736 1.3558492577378305 0.7682049334720118 1.0 19.097366264190732 -7.441081059331617 3.3322162759064726 1.0498967928950336 0.409210853457443 0.7888067347209791 0.14559303517755134 0.10196851988611487 2.1718649753147896 0.06556892652800549 0.04026709860664219 3.6217539351617924e-08 7.441081059331617 -0.6406859394375906 down IEPEPFENCLLRPGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 4 IEPEPFENCLLRPGSPAR 18 1 A0A2R8Y5T7;A0A2R8Y430;P48637-2;P48637 A0A2R8Y5T7 GSS Glutathione synthetase 1 IEPEPFENCLLRPGS(1)PAR;IEPEPFENCLLRPGS(1)PAR;IEPEPFENCLLRPGS(1)PAR;IEPEPFENCLLRPGS(1)PAR 113.7 0.00063071 42797800.0 11667.8 11747.900000000001 10112.9 10008.9 10828.9 8553.9 11376.199999999999 12343.400000000001 7004.0 11330.199999999999 True False 11939.63703841335 10372.450406549464 8739.623726183398 8261.03350532219 9849.427906997571 8467.855532319789 10518.084074968836 12016.012934986156 11885.276448079732 12784.541535493889 0.9339120222078501 0.8113275222073701 0.6836086927262481 0.6461736216654289 0.770416982075773 0.6623511299807171 0.8227189098465003 0.9398861039815893 0.9296599659113692 1.0 13.642112804788466 -7.653564087852045 3.1553839377801114 0.9551515721227058 0.7465090050592346 0.5657176508878425 0.0801672454158817 0.19918903048714492 3.923199219201935 0.04691938503778781 0.02410701365428176 2.2204239963384194e-08 7.653564087852045 -0.20864256706347128 IEPEPFENCLLRPGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 IEPEPFENCLLRPGSPAR 18 1 A0A2R8Y5T7;A0A2R8Y430;P48637-2;P48637 A0A2R8Y5T7 GSS Glutathione synthetase 1 IEPEPFENCLLRPGS(1)PAR;IEPEPFENCLLRPGS(1)PAR 94.176 0.002384 33161000.0 58805.0 56433.0 55774.0 65371.0 63817.0 49503.0 63423.0 53855.0 48520.0 50975.0 True False 55536.8535150664 60761.22963930511 52185.56156213969 56467.35702873503 55799.7379287814 56321.588906507735 66372.2951702904 54011.709133824814 58225.35576207144 49503.21930104428 1.1218836734097988 1.227419761728978 1.0541852085373127 1.1406805017132258 1.1271941242739398 1.1377358826705564 1.3407672492299962 1.0910746795145387 1.17619331801403 1.0 15.595234729360454 -10.52945306686755 4.354780760146825 0.9999930520839541 1.1579547236784427 0.28212220416573985 0.07534855363125914 10668461.476518005 12897671.801583918 577.5052548646279 0.018027416185235873 2.954928203020879e-11 10.52945306686755 0.1579616715944886 IEPGSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 IEPGSSSPR 9 0 Q5JS13-4;Q5JS13-3;Q5JS13-2;Q5JS13-7;Q5JS13 Q5JS13-4 RALGPS1 Ras-specific guanine nucleotide-releasing factor RalGPS1 1 IEPGS(0.005)S(0.065)S(0.93)PR;IEPGS(0.015)S(0.086)S(0.899)PR 128.86 0.004222999999999999 4485100.0 6208.0 8874.5 8325.3 8916.1 7090.1 7178.6 7614.799999999999 6383.4 3390.6 6058.4 True False 6352.634321334785 7835.469414356879 7194.7699875994695 7359.070510925592 6448.801706858826 7106.3898016472995 7040.409505289348 6214.091495794567 5753.600560373947 6836.0546538133685 0.9292837232936814 1.1461975965897238 1.0524740295319315 1.0765084370442342 0.9433513968852604 1.039545492469568 1.0298936831000882 0.9090172344260222 0.8416551434626705 1.0 12.738948215975483 -7.7587560877592345 6.4131199127168115 0.9056174419366716 1.0353098486216001 0.36389485100680263 0.06856075304147925 0.1379107242949103 24.40878677967819 0.034362775475622456 0.017983444594469725 1.7427853968611337e-08 7.7587560877592345 0.12969240668492854 IEPGTST(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 IEPGTSTPR 9 0 Q86X27;Q86X27-3;H7C2H2;A0A0A0MR31 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 IEPGTS(0.002)T(0.998)PR 121.5 0.014597 12432000.0 4579.8 5192.8 5626.8 6417.3 5890.2 4339.7 5290.3 5193.1 2585.5 4295.7 True False 4686.500429260479 4584.824561932776 4862.711465799995 5296.639022640257 5357.432449999273 4296.046558132333 4891.248411755034 5055.362118433867 4387.404662551422 4847.094938661375 0.9668678844889208 0.9458912234962268 1.0032218323214714 1.0927450544434836 1.1052872943063992 0.886313681183801 1.0091092651686029 1.042967423252083 0.9051616933591762 1.0 12.242904625098022 -10.138223561062182 15.09580162361614 0.9999776037749122 0.9987715244186037 0.0 0.06890596572290628 0.0 0.0 0.06881882979215506 0.016691017897909347 7.274052629230985e-11 10.138223561062182 -0.0012060793563084538 IEPGTST(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IEPGTSTPR 9 0 Q86X27;Q86X27-3;H7C2H2;A0A0A0MR31 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 IEPGT(0.002)S(0.023)T(0.975)PR 107.79 0.016772 0.0 137820.0 109320.0 142920.0 149400.0 161730.0 112850.0 102580.0 119780.0 103210.0 113200.0 True False 130160.51613717289 117704.49248079723 133724.6827995304 129051.46227062511 141412.0315154554 128394.06314969594 107350.17325841387 120128.5399693536 123854.88392834674 109931.62187107839 1.1840134250890777 1.0707064125628423 1.2164350941383832 1.1739248459553284 1.286363551347359 1.1679447729814199 0.9765176882799755 1.0927569149323895 1.1266538400897674 1.0 16.746246912175742 -7.123160262432937 7.29375952280582 1.0572082611800513 1.1852651779431373 0.5171885586584242 0.0635227272463975 0.2394444369490512 13.244348646235078 0.025143111920893375 0.019464907582883516 7.530776133413735e-08 7.123160262432937 0.12805691676308606 IEPIPGES(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 IEPIPGESPK 10 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 IEPIPGES(1)PK;IEPIPGES(1)PK;IEPIPGES(1)PK;IEPIPGES(1)PK 158.06 0.00048171 55992100.0 16655.4 20740.5 23274.600000000002 25409.199999999997 14448.9 18333.5 15854.900000000001 15397.3 13319.4 18318.8 True False 17043.43841423315 18312.19261800315 20114.037158226452 20971.960209756588 13141.999546160494 18149.08163548614 14658.952128146779 14988.913586520926 22602.048989513598 20670.196420222557 0.8245416767089262 0.8859225256363569 0.9730936634229567 1.0145989802612037 0.6357946136062403 0.8780314065003321 0.7091830106561196 0.725146161255469 1.0934607746349727 1.0 14.335264477704905 -4.738612803068591 21.659451632727013 0.8650481458832173 0.824540901129915 0.00416953160394018 0.14193365141620826 3073.8832309931217 2915881.1532199676 0.035483657911419206 1.3845654734489288 1.825522528707911e-05 4.738612803068591 -0.04050724475330236 IEPIPGES(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 IEPIPGESPK 10 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 IEPIPGES(1)PK;IEPIPGES(1)PK;IEPIPGES(1)PK;IEPIPGES(1)PK 142.97 0.0011413 36850100.0 460136.0 431243.0 381827.0 345264.0 320669.0 250534.0 374751.0 332360.0 215569.0 343122.0 True False 434563.4831903511 464317.95143520285 357260.666521804 298238.44758637896 280383.6934027672 285042.7843787854 392177.66405501845 333327.11257484 258688.8235011129 333215.1763219802 1.3041527339392243 1.3934477911850578 1.0721620499559392 0.8950326058924645 0.8414493496293733 0.8554315788526792 1.1769501869148475 1.0003359278352666 0.7763416611347446 1.0 18.346094584341508 -5.41878652057977 3.426088459473075 0.9392404626547948 1.3485999259003993 0.6983112513796244 0.10720699220397145 0.13857021820472562 2.9927127271120986 0.03088763871560919 0.07074796117527209 3.8125318407097257e-06 5.41878652057977 0.40935946324560457 IERPGEGS(ph)PMVDNPMR ddPTM_A459_Selumetinib_30min_R1 1 IERPGEGSPMVDNPMR 16 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 IERPGEGS(1)PMVDNPMR 115.53 0.0094607 7517900.0 515.25 893.19 838.76 774.46 715.72 587.13 920.52 809.03 372.68 905.49 True False 527.2543224980265 788.6148995672347 724.8609989788874 639.2150994147033 650.983252370629 581.2240052713872 851.084435285096 787.5718963001972 632.4107405297481 1021.718461719508 0.5160465845069299 0.7718514728999121 0.709452776021075 0.6256274339400033 0.6371454336599265 0.5688690447006433 0.832993106391322 0.7708306405413755 0.618967713929166 1.0 9.996781995773922 -14.522878745251207 0.2216098020309003 2.651857623828219 0.6390853078298794 0.5383673615427494 0.09235585108533388 124.66714335781947 1.244386291424956 91.9122096881722 0.17567592674495822 3.0000000002012272e-15 14.522878745251207 -2.0127723159983395 IERPGEGS(ph)PMVDNPMR ddPTM_A459_Selumetinib_30min_R2 3 IERPGEGSPMVDNPMR 16 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 IERPGEGS(1)PMVDNPMR;IERPGEGS(1)PMVDNPMR;IERPGEGS(1)PMVDNPMR 147.6 0.001484 20827100.0 43792.4 37664.8 46725.0 58269.0 55431.0 45059.0 39807.1 38738.0 39455.0 47738.4 True False 41358.59372286701 40553.569048579695 43718.76437033347 50332.66168036839 48467.262220572586 51265.46824512318 41658.20902627222 38850.72116657887 47347.10246480888 46360.06835274099 0.8921167546212585 0.874752141002441 0.9430263138891304 1.0856899799500084 1.0454527774160844 1.105810885675542 0.8985795428364424 0.8380212227250062 1.0212906095081185 1.0 15.500595072988048 -5.522859824382329 24.99999999895104 0.9961967644636299 0.889798125695068 0.2714186444232892 0.07607561588104651 0.9669730502290361 1275598.4526293892 0.023158994008349004 0.04064182054801399 3.000130703780265e-06 5.522859824382329 -0.10639863876856193 IERS(ph)PLLDQVQTFLPQMAR ddPTM_A459_Selumetinib_30min_R1 2 IERSPLLDQVQTFLPQMAR 19 1 Q8N5I9;A0A087WT30 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 IERS(1)PLLDQVQTFLPQMAR;IERS(1)PLLDQVQTFLPQMAR 107.63 0.00042469 15163700.0 1996.9 2570.4 2843.8 2984.9 2246.6 2054.7 2736.9 2527.9 1577.13 2015.33 True False 2043.423884708994 2269.4563730534587 2457.627579875244 2463.643248512444 2043.3954266694454 2034.0315835183335 2530.45342950917 2460.851880223562 2676.2744209822936 2274.0172364765763 0.8985964802426608 0.9979943584639736 1.0807427228138158 1.0833881155314722 0.8985839658082528 0.8944662119931496 1.112767919661824 1.082160610196813 1.1768927596736185 1.0 11.151027474197893 -7.288378576821843 24.688372409631622 1.0998020638155852 0.9828193000500005 0.3581639389590908 0.07636195190051381 793.6045025442284 727293.5338877012 0.03399992370146459 0.022930393413410657 5.1477971271417136e-08 7.288378576821843 -0.1169827637655847 IES(ph)DEEEDFENVGK ddPTM_A459_Selumetinib_30min_R1 6 IESDEEEDFENVGK 14 0 Q96T23-3;Q96T23-2;Q96T23 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK 238.65 1.964e-19 241808400.0 17275.100000000002 19089.199999999997 19952.800000000003 19677.399999999998 16581.300000000003 16330.7 17289.0 17929.100000000002 10592.380000000001 15456.099999999999 True False 17677.576218506863 16854.22758967167 17243.319352885148 16241.111480545003 15081.524342666293 16166.427985089222 15984.87681054624 17453.5620260755 17974.495223174017 17440.040990163205 1.0136201072278235 0.9664098610306047 0.9887201161173294 0.9312542034566066 0.864764271550325 0.9269719030022725 0.91656188305763 1.0007752869342406 1.0306452394987067 1.0 14.090115810503491 -7.880685060980638 5.715667230634657 1.015205147339788 0.942593494161062 0.37859214016141385 0.039185854113930815 0.23723494295855538 10.792484236308129 0.02446645846922665 0.011520758749336661 1.3161789448085494e-08 7.880685060980638 -0.07261165317872609 IES(ph)DEEEDFENVGK ddPTM_A459_Selumetinib_30min_R2 4 IESDEEEDFENVGK 14 0 Q96T23-3;Q96T23-2;Q96T23 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK;IES(1)DEEEDFENVGK 246.77 2.8064e-27 111252200.0 120289.0 103273.8 107747.0 116073.7 102280.8 88629.6 106757.1 107682.2 76105.2 110088.5 True False 113603.81893501962 111194.56838239417 100814.67532606365 100264.26182169914 89431.37150204649 100837.52290059623 111721.51668518053 107995.53737425202 91328.36655695792 106909.95896072603 1.062612127432886 1.040076803539342 0.9429867554537037 0.9378383716201012 0.8365111386386334 0.9432004640244924 1.0450057017253374 1.0101541374075804 0.8542549959308086 1.0 16.70603672482013 -5.2114757070481765 4.150556480317485 0.9455239603588612 1.0566815019621125 0.3224663652844847 0.06118289342765175 0.2721955479182502 10.008058346152607 0.01697324636046145 0.04825118610855705 6.14503403968602e-06 5.2114757070481765 0.11115754160325131 IES(ph)DVQEPTEPEDDLDIMLGNK ddPTM_A459_Selumetinib_30min_R1 5 IESDVQEPTEPEDDLDIMLGNK 22 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 IES(1)DVQEPTEPEDDLDIMLGNK;IES(1)DVQEPTEPEDDLDIMLGNK;IES(0.731)DVQEPT(0.269)EPEDDLDIMLGNK;IES(1)DVQEPTEPEDDLDIMLGNK;IES(1)DVQEPTEPEDDLDIMLGNK 184.4 4.046e-17 24800800.0 10270.150000000001 10673.849999999999 10587.029999999999 10435.6 9161.09 9697.77 10062.46 9256.26 6025.58 9228.73 True False 10509.424512766833 9424.150679861754 9149.36947639307 8613.218360473205 8332.471027021802 9600.219238670652 9303.44054086697 9010.753916230125 10224.969169049156 10413.327390942663 1.0092282820098168 0.9050085842935008 0.8786211297218062 0.8271341173777786 0.8001737306626165 0.9219165861452471 0.8934166949325867 0.8653097687169163 0.9819118121593549 1.0 13.346143509030977 -8.321139613153802 5.412744232004881 0.9956904586068301 0.8843025541135785 0.3750019684591396 0.05329159149088236 0.24607124812696646 14.719367624021013 0.05309806083097576 0.014107823576946128 4.773757864371199e-09 8.321139613153802 -0.11138790449325164 IES(ph)DVQEPTEPEDDLDIMLGNKK ddPTM_A459_Selumetinib_30min_R1 1 IESDVQEPTEPEDDLDIMLGNKK 23 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 IES(0.869)DVQEPT(0.131)EPEDDLDIMLGNKK 91.691 7.285e-05 4563900.0 1164.2 1145.0 1690.7 1600.6 1080.6 1129.1 978.44 1215.0 629.47 829.49 True False 1191.323594861141 1010.9428677039419 1461.1122263503328 1321.085256983155 982.859920795425 1117.7422791407748 904.6354830534362 1182.7742531237898 1068.1646153302047 935.963121416818 1.2728317682621617 1.0801097228848322 1.5610788426562878 1.411471485097999 1.0501053923018 1.1942161539963112 0.9665289821291683 1.2636974962575025 1.1412464774394808 1.0 9.870307875996616 -6.264365485528825 24.976800730962196 1.1135913041144896 1.3298331462417146 0.3914178063037974 0.1393227081312505 296.8915235737533 2534219.8688238575 0.04392920709843813 0.05198034709051911 5.440446131179393e-07 6.264365485528825 0.21624184212722497 IES(ph)YEGR ddPTM_A459_Selumetinib_30min_R2 1 IESYEGR 7 0 C9JPX5;C9JKL2;O95772-2;O95772;C9JJ39;C9J3F5 C9JPX5 STARD3NL MLN64 N-terminal domain homolog 1 IES(1)YEGR 101.25 0.01659 0.0 28217.0 7936.5 16530.0 22753.0 15370.0 11737.0 26802.0 21968.0 16628.0 13434.0 True False 26648.81210160068 8545.204030130331 15466.477796503192 19654.002148885724 13439.083190456611 13353.66521212211 28048.34610715547 22031.923243001813 19954.064625138566 13046.125514276195 2.0426610239522267 0.6549993728620372 1.1855226886770664 1.5065010778394414 1.0301206420059663 1.0235732591649052 2.1499368587602925 1.6887713688552655 1.5295011996705925 1.0 13.671333793142887 -7.230381032934254 24.927184425286775 1.6494502968085376 1.2139671799286882 0.13146372920087523 0.42939722903344696 1061.3786316465412 851855.117716837 0.1573015554794397 0.12183119681079625 5.883272536103682e-08 7.230381032934254 -0.4354831168798494 IESDVQEPT(ph)EPEDDLDIMLGNK ddPTM_A459_Selumetinib_30min_R1 5 IESDVQEPTEPEDDLDIMLGNK 22 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 IES(0.064)DVQEPT(0.936)EPEDDLDIMLGNK;IESDVQEPT(1)EPEDDLDIMLGNK;IES(0.025)DVQEPT(0.975)EPEDDLDIMLGNK;IESDVQEPT(1)EPEDDLDIMLGNK;IES(0.002)DVQEPT(0.998)EPEDDLDIMLGNK 188.08 1.6482999999999994e-21 64344500.0 8389.82 10464.59 9012.63 9421.17 8349.67 8229.08 8341.82 7889.2 4602.26 7457.620000000001 True False 8585.2864822521 9239.39093794409 7788.764348832913 7775.939516763705 7594.443822753968 8146.302926606821 7712.589801362192 7679.952788266831 7809.699084228933 8414.878170370333 1.0202508352981023 1.0979827337818096 0.9255944282423443 0.924070361962411 0.9025019339548846 0.9680832879186303 0.916542063379958 0.9126635742997146 0.9280822521860983 1.0 13.038726669197123 -5.270837295232091 24.945637167677056 0.9305883857214461 1.0591167851022563 0.69865013070751 0.03259772703932931 270.62384411469344 718339.8745908953 0.007918585013280634 0.01686072170630641 5.359974268219149e-06 5.270837295232091 0.12852839938081018 IESDVQEPT(ph)EPEDDLDIMLGNK ddPTM_A459_Selumetinib_30min_R2 5 IESDVQEPTEPEDDLDIMLGNK 22 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 IESDVQEPT(1)EPEDDLDIMLGNK;IES(0.004)DVQEPT(0.996)EPEDDLDIMLGNK;IES(0.005)DVQEPT(0.995)EPEDDLDIMLGNK;IESDVQEPT(1)EPEDDLDIMLGNK;IES(0.002)DVQEPT(0.998)EPEDDLDIMLGNK 130.29 3.3246999999999995e-05 7366200.0 110560.5 105030.6 105833.1 115180.2 103209.1 111571.4 110093.0 109994.6 87820.7 120758.6 True False 104415.99001874837 113086.10929339236 99023.9135683669 99492.45806307242 90243.05015693913 126939.34760567124 115212.54264514089 110314.66607541377 105387.29391537796 117271.98544947701 0.8903745393117162 0.9643062566047541 0.8443953019881997 0.8483906679139125 0.7695192488731041 1.0824353925546788 0.9824387487221031 0.9406736455650733 0.8986570280314798 1.0 16.83949889035928 -6.759035267090267 24.99999999998269 0.977232918627512 0.8671139179226214 0.4651037941985491 0.06285111230494264 67.76350698709689 704664.2465853055 0.02271379728940423 0.021696190594433888 1.7416654348776674e-07 6.759035267090267 -0.11011900070489067 IESDVQEPT(ph)EPEDDLDIMLGNKK ddPTM_A459_Selumetinib_30min_R1 2 IESDVQEPTEPEDDLDIMLGNKK 23 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 IESDVQEPT(1)EPEDDLDIMLGNKK;IESDVQEPT(1)EPEDDLDIMLGNKK 144.26 7.400100000000002e-07 20199500.0 6100.3 5456.9 7499.9 7924.9 6067.2 6269.2 5505.700000000001 4956.8 3158.4 4301.0 True False 6242.425120882508 4818.003611156017 6481.454774001807 6540.964983797202 5518.4228312511605 6206.137539978159 5090.4006163355 4825.329562044446 5359.574119590954 4853.075245287748 1.286282368472196 0.9927733174617919 1.3355356029756982 1.3477979741089665 1.137098139290021 1.2788051341269047 1.0489020588086266 0.9942828656385985 1.1043665817452568 1.0 12.244683513435518 -7.286804381245021 12.655741818739557 1.0363723388630453 1.2249087940104886 0.4626509353503616 0.10172698513518817 1.7649109188569707 878.1063738788208 0.04276466205411576 0.029032932665210363 5.1664903048734833e-08 7.286804381245021 0.18853645514744333 IESDVQEPT(ph)EPEDDLDIMLGNKK ddPTM_A459_Selumetinib_30min_R2 4 IESDVQEPTEPEDDLDIMLGNKK 23 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 IESDVQEPT(1)EPEDDLDIMLGNKK;IES(0.001)DVQEPT(0.999)EPEDDLDIMLGNKK;IES(0.002)DVQEPT(0.998)EPEDDLDIMLGNKK;IES(0.012)DVQEPT(0.988)EPEDDLDIMLGNKK 98.0 0.00015787 5157700.0 48494.7 51899.0 46904.9 49210.9 50614.2 38718.9 30477.9 31532.0 23499.100000000002 57050.6 True False 45799.558713665334 55879.48641841285 43887.089800193746 42508.290526462486 44255.591699310964 44052.07701982066 31895.182740813125 31623.7528995964 28199.576619713374 55403.4009427397 0.8266560885134092 1.0085930731249728 0.792137108073054 0.7672505622966266 0.7987883585892105 0.7951150339191123 0.5756899792808262 0.5707908244167186 0.5089863824218677 1.0 15.757686918506732 -6.523462902867612 0.9607508518475837 0.6388479057004187 0.8869972113548057 0.23057907191912563 0.1415065421005924 0.6621874975076935 1.325737839798222 0.07327099379735957 0.08642644760829232 2.9959674949566464e-07 6.523462902867612 0.24814930565438698 IESPKLER ddPTM_A459_Selumetinib_30min_R1 1 IESPKLER 8 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;Q5TBM3 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 124.08 0.01577 10533000.0 6649.2 6681.3 8543.7 8423.0 6006.4 7282.6 6424.8 6295.6 4621.1 5365.0 False True 6804.11342290903 5899.050289947895 7383.512467184798 6952.081169292212 5463.12218051605 7209.343656071745 5940.1721633638435 6128.620237009156 7841.669188209775 6053.650009525403 1.1239687481441403 0.974461734765927 1.2196794422483723 1.148411480404901 0.9024509464405509 1.1909085666875125 0.9812546404263539 1.0123843015975134 1.2953621659446661 1.0 12.563589553134753 -3.381141171008802 11.136611872808123 1.0826719969338892 1.0860772850178453 0.0 0.12165524720213093 0.0 0.0 0.026474537883089646 0.0 0.00041577543728525446 3.381141171008802 0.003405288083956126 IET(ph)DEEESCDNAHGDANQPAR ddPTM_A459_Selumetinib_30min_R1 2 IETDEEESCDNAHGDANQPAR 21 0 Q96T23-3;Q96T23-2;Q96T23 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 IET(0.938)DEEES(0.062)CDNAHGDANQPAR;IET(1)DEEESCDNAHGDANQPAR 237.71 8.5717e-31 86983000.0 2263.26 2670.87 2336.79 2773.84 2381.89 2294.97 2459.73 2598.13 1507.3799999999999 2100.8199999999997 True False 2315.989554462658 2358.163298746222 2019.4667530686675 2289.440915425563 2166.448470056835 2271.8846854660387 2274.1905857600163 2529.21915248437 2557.913765320734 2370.4807107196953 0.9770126135131074 0.9948038337043741 0.8519228795814764 0.9658129277628554 0.9139279051121599 0.9584067380055913 0.959379494410463 1.0669646629254708 1.0790696392311636 1.0 11.210963938151512 -7.700747977253734 4.921632051983904 1.054987883875576 0.9429970907811975 0.557456948724631 0.04194743536153012 0.138920919916563 6.666141729767537 0.0209809156386066 0.011448168669848829 1.9918288695744607e-08 7.700747977253734 -0.11199079309437843 IET(ph)DEEESCDNAHGDANQPAR ddPTM_A459_Selumetinib_30min_R2 2 IETDEEESCDNAHGDANQPAR 21 0 Q96T23-3;Q96T23-2;Q96T23 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 IET(1)DEEESCDNAHGDANQPAR;IET(1)DEEESCDNAHGDANQPAR 192.16 2.2269000000000003e-16 223530000.0 222061.0 231904.0 238937.0 296090.0 244519.0 181395.0 188229.0 207804.0 167134.0 213193.0 True False 209719.73860061512 249690.291111112 223564.05355493512 255762.03121625987 213800.337192405 206380.51471013826 196982.02146868766 208408.6752361961 200565.4701141399 207037.56414806368 1.0129550135676504 1.2060144357791278 1.079823627537718 1.2353411916754908 1.0326644735807695 0.9968264240326189 0.9514313128598018 1.0066225232786832 0.9687395180649669 1.0 17.65953302328935 -6.4755233180961795 6.462615914853489 0.9861154994293903 1.1354193313850212 0.5833423901420218 0.0594317623988245 0.1471148596895701 15.404663587787093 0.017514151866377503 0.01956881622386362 3.345620540984779e-07 6.4755233180961795 0.1493038319556309 IETIAASST(ph)PTPIR ddPTM_A459_Selumetinib_30min_R1 1 IETIAASSTPTPIR 14 0 Q96P47;Q96P47-2;Q96P47-4;Q96P47-5;H7C5G0;H7C4U6;E7ESL9;Q96P47-3;Q96P47-6 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 IETIAAS(0.007)S(0.044)T(0.948)PTPIR 145.61 0.0012011 8946300.0 2501.3 2998.2 2903.7 2401.6 3095.3 2573.6 2370.1 1890.0 1582.0 2213.9 True False 2559.575423317446 2647.169350174635 2509.3934888823924 1982.2056436153593 2815.330661519599 2547.7119206418356 2191.321448821543 1839.8710604147839 2684.538455291567 2498.07563021217 1.0246188675640908 1.0596834291801653 1.0045306309117876 0.7934930470647936 1.1269997703314063 1.019869810917394 0.8772038053289151 0.7365153553251378 1.0746425860067177 1.0 11.28660144042314 -7.259270700059505 24.660013776231672 0.900133381195377 1.0032860722391104 0.099693163577383 0.11443510941979171 315.96916330288786 3592909.272967597 0.045131594563613556 0.0332176668614472 5.504644794796605e-08 7.259270700059505 0.10315269104373337 IETIAASST(ph)PTPIR ddPTM_A459_Selumetinib_30min_R2 1 IETIAASSTPTPIR 14 0 Q96P47;Q96P47-2;Q96P47-4;Q96P47-5;H7C5G0;H7C4U6;E7ESL9;Q96P47-3;Q96P47-6 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 IETIAAS(0.049)S(0.031)T(0.919)PT(0.001)PIR 158.31 0.00071738 6650000.0 57007.0 50116.0 44727.0 53108.0 63658.0 44442.0 75566.0 53371.0 43697.0 41222.0 True False 53838.77915710209 53959.73605166151 41849.31351507554 45874.598783589994 55660.71293025943 50563.4820956915 79079.96873118835 53526.300773955336 52437.62099619195 40031.81375238151 1.3448998211803282 1.3479213403977086 1.0454013843573577 1.1459535425336778 1.3904119677052642 1.2630824675707695 1.9754280737900327 1.3370940698576526 1.309898705078593 1.0 15.288859362056991 -6.581995349928743 2.429371341987691 1.4383890390119616 1.222033983806483 0.06032517248127167 0.24666842690027765 0.6258049121176383 7.491451606541635 0.08975614237976706 0.09270370674117005 2.6182110417382644e-07 6.581995349928743 -0.21635505520547849 IETIEVMEDR ddPTM_A459_Selumetinib_30min_R1 2 IETIEVMEDR 10 0 P51991;P51991-2 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 ; 179.1 0.001449 21778000.0 4253.1 4928.3 4254.1 4741.4 4459.5 3556.0 4453.7 4442.7 2434.5299999999997 3563.2 False True 4352.1889549080215 4351.292344895491 3676.416586098631 3913.4034971010424 4056.1390123886704 3520.2298685896667 4117.753823305557 4324.865164076591 4131.219598963958 4020.571428507162 1.0824801977275127 1.0822571921104074 0.9144015102011716 0.9733450994935038 1.008846400198072 0.8755546148565075 1.0241712892126078 1.075684200860576 1.0275205085705639 1.0 11.973184845391296 -10.18839968812741 8.97354998399534 1.0000054810870844 1.0043248043125181 0.0 0.06622232041297918 0.0 0.0 0.06811254330539589 0.016519718263388494 6.480377595565784e-11 10.18839968812741 0.004319323225433713 IETIEVMEDR ddPTM_A459_Selumetinib_30min_R2 2 IETIEVMEDR 10 0 P51991;P51991-2 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 ; 195.57 0.0023248 16650300.0 44822.0 34855.0 49586.0 48697.0 51551.0 35017.0 33870.0 40038.0 30581.0 38518.0 False True 42330.972676682344 37528.26642351069 46395.6907451547 42064.38459298942 45074.70250821268 39840.27389732302 35445.02211213175 40154.50395135228 36698.05450453226 37405.88525821721 1.1316661104119492 1.0032717088353522 1.240331312168655 1.1245392082720151 1.20501632823436 1.0650803642876232 0.9475787531146665 1.073480915480573 0.9810770217360526 1.0 15.190977654070705 -6.989442840601452 8.967258078840514 1.0065456923468725 1.1377567388165406 0.5104689641665383 0.0648025881402877 0.1401673943645137 90.735271908346 0.023021032371759596 0.019869656958416217 1.0246066244010878e-07 6.989442840601452 0.13121104646966808 IETSIGQSTVIIDLT(ph)EDSNEQPDSLVDHNK ddPTM_A459_Selumetinib_30min_R1 1 IETSIGQSTVIIDLTEDSNEQPDSLVDHNK 30 0 Q13111;Q13111-3;Q13111-2;K7EJF1 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 IETSIGQSTVIIDLT(0.493)EDS(0.493)NEQPDS(0.014)LVDHNK 92.924 3.9057e-05 0.0 265.36 247.01 180.11 178.29 339.15 179.26 296.13 290.22 0.0 241.29 True False 271.54237169932344 218.08995436816647 155.6520512734125 147.1549984177975 308.47394238179567 177.45680715505736 273.7926756843691 282.5224228325813 0.0 272.261921863632 0.9973571399210612 0.8010299526108589 0.5716996714339438 0.5404905592766039 1.1330043520970268 0.65178709508978 1.0056223573618341 1.037686140238474 0.0 1.0 8.088851413141018 -11.738857364803053 2.4237900915854187 1.7899974800181122 0.7634515415579749 0.051607427971157915 0.31754561595132863 73729906.8525871 11876516.607387451 320483507.97198385 0.07777318000638181 1.824494822177255e-12 11.738857364803053 -1.0265459384601372 IEVDEGFCS(ph)PKPSEIK ddPTM_A459_Selumetinib_30min_R2 1 IEVDEGFCSPKPSEIK 16 1 Q9UHV7 Q9UHV7 MED13 Mediator of RNA polymerase II transcription subunit 13 1 IEVDEGFCS(0.856)PKPS(0.144)EIK 64.346 0.032222 24232000.0 72409.0 52664.0 60352.0 52023.0 52253.0 46688.0 69390.0 63817.0 44051.0 44860.0 True False 68384.79765619329 56703.15945855017 56469.0180262892 44937.37765531941 45688.51099225308 53118.84820853348 72616.77249367659 64002.696904526936 52862.43088777839 43564.775239722345 1.5697268556969406 1.3015827384975982 1.2962081800160596 1.0315071616470899 1.048748920219249 1.2193072939373215 1.6668689805947774 1.4691386918064322 1.213421407476434 1.0 15.410874479542768 IEVIEIMTDR ddPTM_A459_Selumetinib_30min_R1 1 IEVIEIMTDR 10 0 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8VZ49;Q32P51;A0A2R8Y4L2;H0YH80;F8VYN5 F8W6I7 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 142.43 0.016628 18477000.0 1548.9 1497.4 1587.7 1874.8 2005.1 1774.8 1609.7 1589.7 969.8 1329.8 False True 1584.9863563652466 1322.0837118776255 1372.0990606118312 1547.4013743546282 1823.7390590291575 1756.9471233894676 1488.2790330230944 1547.5359919266557 1645.6797686104696 1500.4927833489064 1.0563105494101488 0.8810996804175927 0.9144322957351938 1.0312621237011403 1.215426744645054 1.1709134111716206 0.9918601738966365 1.0313518392755978 1.096759535848966 1.0 10.551220664943319 -5.953226386025038 5.682209260500049 1.0889069440005392 0.9461528803018693 0.36863000795393275 0.0780455604709197 0.20204704181324387 15.182674595941126 0.023513838161499823 0.034934537216914016 1.1137138332058096e-06 5.953226386025038 -0.14275406369866994 IEVLDS(ph)PASK ddPTM_A459_Selumetinib_30min_R1 4 IEVLDSPASK 10 0 Q8N5I9 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 IEVLDS(1)PASK;IEVLDS(0.84)PAS(0.16)K;IEVLDS(0.998)PAS(0.002)K;IEVLDS(0.981)PAS(0.019)K 177.1 7.7475e-05 146179000.0 28216.3 27702.9 25450.0 24826.2 21617.0 22652.4 23103.0 22344.6 13169.1 21602.100000000002 True False 28873.684890637705 24459.431589271204 21994.02978684331 20490.770215491197 19661.746166791338 22424.537422733585 21360.322109668003 21751.948622510143 22347.000866991268 24374.939957272847 1.184564349337917 1.0034663319026207 0.9023213934227914 0.840649053963199 0.8066377271598072 0.9199832886580173 0.8763230657023481 0.892389834011465 0.9168022939200515 1.0 14.573111044629076 -4.8352696484100814 1.9233085276310713 0.8849032568129888 1.2557184264927452 0.7685201413940946 0.0489358282217658 0.3077641226499953 1.342561795430286 0.013201186885641408 0.19891318327989446 1.461269607374701e-05 4.8352696484100814 0.3708151696797565 IEVLDS(ph)PASK ddPTM_A459_Selumetinib_30min_R2 5 IEVLDSPASK 10 0 Q8N5I9 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 IEVLDS(0.997)PAS(0.003)K;IEVLDS(0.961)PAS(0.039)K;IEVLDS(1)PASK;IEVLDS(0.608)PAS(0.392)K;IEVLDS(0.994)PAS(0.006)K 164.48 0.00037477 98435900.0 292363.0 253903.0 286317.0 301483.0 293274.0 236636.0 273323.0 257075.0 218706.0 251903.0 True False 276114.63488181855 273376.54367317865 267895.67593837855 260420.49531281626 256430.2982171746 269230.4610322681 286033.06107925 257823.04568894254 262453.31115621584 244629.9058674042 1.1287035160430463 1.1175107258609496 1.0951059928199662 1.0645488922927149 1.0482377340903142 1.1005623375344717 1.1692481345035852 1.0539310178563752 1.0728586524432233 1.0 17.900241257734905 -8.643955614624034 1.5007981652521778 1.001119424624463 1.098588571630629 0.4321062332468303 0.03413373176442472 0.5805994888731818 2.728679830349578 0.03476394196882983 0.010172521824351424 2.2700968464348405e-09 8.643955614624034 0.09746914700616593 IEVLDSPAS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 IEVLDSPASK 10 0 Q8N5I9 Q8N5I9 C12orf45 Uncharacterized protein C12orf45 1 IEVLDS(0.315)PAS(0.685)K 120.57 0.0050461 4617700.0 65364.0 53471.0 66323.0 65652.0 73631.0 59019.0 59034.0 53284.0 45053.0 65180.0 True False 61731.33055282377 57572.05376363623 62055.85038702246 56710.08434398302 64380.81551050815 67148.33152886051 61779.19797365178 53439.04761835893 54064.858885997615 63298.084042021874 0.9752480108535674 0.9095386477324607 0.9803748616755172 0.8959210251345797 1.0171052802762164 1.0608272358493909 0.9760042331239956 0.844244315244711 0.8541310484232892 1.0 15.949874211195059 -7.743967729024912 24.910948919349934 0.8868907682253633 0.9734163633505721 0.23818589581527339 0.05948055714344292 282.8744436015717 403321.5247463417 0.02886363874003222 0.016613896467573802 1.8031517220747318e-08 7.743967729024912 0.08652559512520885 IEVLPVDTGAGGYSGNSGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 IEVLPVDTGAGGYSGNSGSPK 21 0 X6RAB3;Q92738;Q92738-2 X6RAB3 USP6NL USP6 N-terminal-like protein 1 IEVLPVDTGAGGYS(0.186)GNS(0.003)GS(0.811)PK 218.95 1.9793e-20 18762000.0 5838.1 5568.7 7810.8 6972.0 4620.3 5137.2 5370.4 5466.1 3985.5 6391.5 True False 5974.116371034894 4916.714015181604 6750.136261653267 5754.471080648856 4202.394680780217 5085.524432204399 4965.306404266156 5321.121271604894 6763.102410597055 7211.9112834821335 0.8283679785021435 0.6817490983898602 0.9359705071682597 0.7979120727439702 0.582701937890613 0.7051562661138214 0.6884868946791527 0.7378240056546692 0.9377683868750559 1.0 12.816165934390245 -8.345249734257314 3.6171016469131203 0.9946716830776687 0.7416617875398467 0.49959024813633635 0.090505947845109 0.20312780412717713 4.7483926328181525 0.09058420434089842 0.024395917841341173 4.515961863650085e-09 8.345249734257314 -0.25300989553782205 IEVLPVDTGAGGYSGNSGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 IEVLPVDTGAGGYSGNSGSPK 21 0 X6RAB3;Q92738;Q92738-2 X6RAB3 USP6NL USP6 N-terminal-like protein 1 IEVLPVDTGAGGYS(0.001)GNS(0.028)GS(0.972)PK;IEVLPVDT(0.001)GAGGY(0.009)S(0.013)GNS(0.138)GS(0.839)PK;IEVLPVDTGAGGYS(0.023)GNS(0.132)GS(0.845)PK 294.62 3.7379999999999995e-87 18916000.0 213410.0 161247.0 160263.0 155350.0 114553.0 114518.0 192283.0 144771.0 103315.0 131360.0 True False 201549.52654791818 173614.1264091757 149951.85306116068 134191.06200630256 100161.82802318654 130291.81500909933 201224.54050153604 145192.25964187062 123980.88686229177 127567.29548573158 1.5799466922967065 1.360961097028152 1.1754725416902236 1.0519237042327345 0.7851685468583885 1.0213575079176347 1.5773991267537928 1.138162089970077 0.971886143624947 1.0 16.960898986234298 -5.043001333599257 1.8577527426999516 1.0917676503804803 1.6125313393778526 0.41666306135152864 0.19073930945960965 0.5645776552324251 2.9481098679259783 0.058508411527778637 0.4292022582070002 9.057298196460329e-06 5.043001333599257 0.5207636889973724 IEWLESHQDADIEDFK ddPTM_A459_Selumetinib_30min_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 95.662 0.012049 21727000.0 3111.1 3831.9 3000.2 3251.4 3107.2 3230.0 3213.8 3203.3 1853.4 3678.6 False True 3183.5825768531995 3383.259366598019 2592.7893189189513 2683.604026337016 2826.1543086207157 3197.5091326053525 2971.3804785547777 3118.338078215171 3145.0844330198424 4150.784142598351 0.7669834102383141 0.8150892097414951 0.62465048285934 0.6465294108638243 0.68087238736813 0.7703385728470435 0.715860034266856 0.7512648143305091 0.7577085015678628 1.0 12.01916819263343 -9.48788085311137 0.6704592164452111 1.0122306058094481 0.7124844834618403 0.6995211680818603 0.054754718079192556 2.644703787295696 1.356399877891087 0.14403724782673138 0.022608626439579674 3.2517649597131255e-10 9.48788085311137 -0.2997461223476078 IEYNDQNDGSCDVK ddPTM_A459_Selumetinib_30min_R2 2 IEYNDQNDGSCDVK 14 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 ; 257.2 1.7672999999999998e-34 14541600.0 41551.0 48866.0 51479.0 54237.0 47141.0 32408.0 35097.0 35569.0 34024.0 47072.0 False True 39241.761761831876 52613.865071044995 48166.89718609727 46849.82703595638 41218.72613411288 36871.90782946693 36729.080043386144 35672.49990123505 40829.75070999008 45712.909052256095 0.8584393899975429 1.1509629590823058 1.053682607051674 1.0248708298655995 0.9016867880141746 0.8065972740285967 0.803472822116829 0.7803594354596098 0.8931776943645416 1.0 15.480314010823962 -6.370482511831083 3.016087795382521 0.8402773533929153 1.0352727695008546 0.42591627961170886 0.08928421478220772 0.216541568870966 3.7799551450141147 0.028356839166899774 0.03295938080727358 4.2610584166610104e-07 6.370482511831083 0.19499541610793925 IFDEVMGCFSDS(ph)PPQSPTFPEAGHTSLYDEDKVPR ddPTM_A459_Selumetinib_30min_R1 1 IFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPR 35 1 Q13085;Q13085-4;Q13085-2;Q13085-3 Q13085 ACACA Acetyl-CoA carboxylase 1;Biotin carboxylase 1 IFDEVMGCFS(0.099)DS(0.591)PPQS(0.213)PT(0.081)FPEAGHT(0.007)S(0.006)LY(0.003)DEDKVPR 44.815 0.008798 8735600.0 463.25 680.39 751.34 700.31 896.24 509.75 809.47 485.88 248.89 628.25 True False 474.0428236724132 600.7296224952702 649.3121548152 578.0140049468158 815.1752502440239 504.6223778159682 748.4110261919639 472.99288403933076 422.3481517936272 708.8920071732217 0.668709505644882 0.8474205046982263 0.9159535560351394 0.8153766710555884 1.1499286802437192 0.7118466179752834 1.0557475872472144 0.6672284060945157 0.5957863080975945 1.0 9.469422053371524 -13.579382903844474 15.145634900041003 0.9964270177926833 0.845763764850728 0.0 0.17603881982142427 0.0 0.0 0.0 0.03948369776400956 2.634008039362379e-14 13.579382903844474 -0.15066325294195526 IFINNEWHDSVSGK ddPTM_A459_Selumetinib_30min_R1 2 IFINNEWHDSVSGK 14 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 125.47 0.0019346 29383000.0 6789.3 8664.599999999999 6941.7 9093.5 13730.400000000001 8023.7 11562.400000000001 6318.9 2830.0 3994.5 False True 6947.477480321888 7650.144603936741 5999.055268028691 7505.490931136021 12488.487744299004 7942.988862936708 10690.238859058358 6151.302245320088 4802.30330497796 4507.232984724925 1.5414063359642125 1.6973040066628877 1.3309840623636657 1.66521033116598 2.7707659636461357 1.762276077108862 2.3717963760222127 1.3647624310007798 1.0654659568859726 1.0 12.138026311422639 -7.96750385821375 7.93128619576645 1.0913425733903193 1.8719744021432896 0.4350163406137032 0.3942276968452492 0.2070115461861744 42.8347087673058 0.23378362320816654 0.11038462258863295 1.0776956795483644e-08 7.96750385821375 0.7806318287529703 IFLGADAEEEIGT(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 IFLGADAEEEIGTPR 15 0 P28749;P28749-2;H0YE05 P28749 RBL1 Retinoblastoma-like protein 1 1 IFLGADAEEEIGT(1)PR;IFLGADAEEEIGT(1)PR;IFLGADAEEEIGT(1)PR;IFLGADAEEEIGT(1)PR;IFLGADAEEEIGT(1)PR;IFLGADAEEEIGT(1)PR 210.08 2.9513e-06 48005400.0 6168.66 7899.160000000001 7486.049999999999 7584.85 6726.85 6696.709999999999 6306.490000000001 6599.25 3644.92 5494.95 True False 6312.377775877104 6974.322674980141 6469.485527929202 6260.298332768138 6118.407605221829 6629.347177526181 5830.786381915774 6424.21645261495 6185.163025576071 6200.280357845594 1.0180794111817324 1.1248398898858023 1.0434182253941093 1.0096798808212921 0.9867953144215218 1.069201196545518 0.9404068921718552 1.0361170917837603 0.9975618308532784 1.0 12.598117735924326 -5.60231811666486 3.903458737738519 1.006459270129854 1.0741819348873984 0.31403446092270615 0.039376665125944434 0.23067841819452378 6.802429936900761 0.010227354602565847 0.018996150368117817 2.49851455260352e-06 5.60231811666486 0.0677226647575444 IFLGADAEEEIGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IFLGADAEEEIGTPR 15 0 P28749;P28749-2;H0YE05 P28749 RBL1 Retinoblastoma-like protein 1 1 IFLGADAEEEIGT(1)PR 115.04 0.005660899999999999 1687600.0 5758.0 4602.8 5643.9 6079.0 5184.3 5159.6 3048.5 3596.0 3343.0 3453.9 True False 5437.993411100289 4955.819959665329 5280.777618613697 5251.029713140081 4533.001885769959 5870.288065814543 3190.2612904881507 3606.4637646501537 4011.6934112243343 3354.1769326900812 1.6212601541979386 1.477507018596874 1.5743885085926175 1.5655195949751841 1.3514498420136856 1.750142638154308 0.9511308897856892 1.0752157196900571 1.196029157593341 1.0 11.711743077673457 -7.268318537419877 24.999958451775374 1.0618619004837337 1.5449849219219731 0.8274544231281202 0.11201359374124291 217.61507089838338 790844.373521012 0.04432116339617057 0.030619295420081648 5.391150583986978e-08 7.268318537419877 0.4831230214382394 IFPGLS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 IFPGLSPVR 9 0 Q5VZK9-2;Q5VZK9;A0A0U1RR91;Q5VZK9-3 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 IFPGLS(1)PVR 110.53 0.010796 2803900.0 15018.0 13490.0 15472.0 18125.0 16855.0 13992.0 11192.0 13239.0 9926.8 16381.0 True False 14183.359681817314 14524.639622813345 14476.548364639897 15656.343732631029 14737.524214388166 15919.270993270233 11712.450176527278 13277.523298165572 11912.437377966411 15908.037967050639 0.8915844751687451 0.9130377770594561 0.9100146978919902 0.9841781723842419 0.9264199799442968 1.0007061226684812 0.7362598832606869 0.8346424194904806 0.7488313393920687 1.0 13.957468290029395 -7.256786281218448 24.99924947246123 0.8161536122343158 0.9368851948206246 0.33071183307815366 0.07403970031193276 398.61241779341333 2141592.3296142486 0.027195567679061325 0.020369729961036868 5.536224829606214e-08 7.256786281218448 0.12073158258630878 IFQVAQELSGEDMHQFHR ddPTM_A459_Selumetinib_30min_R1 1 IFQVAQELSGEDMHQFHR 18 0 C4P0D4;Q5VVQ1;C4P0D6;C4P0D8;Q99598 C4P0D4 DISC1;TSNAX Translin-associated protein X 0 97.214 0.0019287 8840100.0 4538.8 6518.6 5570.8 6393.1 5552.1 5353.2 5408.6 4267.5 2141.4 3457.2 False True 4644.545209032591 5755.399281585073 4814.315958214012 5276.665098349996 5049.913535302873 5299.3516683167045 5000.624947511156 4154.312037206398 3633.799398332086 3900.9652959797263 1.1906143368717446 1.4753782320279798 1.2341345264403072 1.3526562524891068 1.294529213194292 1.3584718822744035 1.2818942410650824 1.064944628317449 0.931512875050958 1.0 11.929615448484533 -7.826576114498281 2.82490060884927 0.9699693308363306 1.3222003042419348 0.7969708421980976 0.0737754845635995 0.10407605803562692 1.6494101790712379 0.04394931634826021 0.018799899013950547 1.4908154520765735e-08 7.826576114498281 0.35223097340560416 IFSLS(ph)GTLETVR ddPTM_A459_Selumetinib_30min_R2 1 IFSLSGTLETVR 12 0 B4DEM9;Q9Y2S7 B4DEM9 POLDIP2 Polymerase delta-interacting protein 2 1 IFS(0.003)LS(0.734)GT(0.261)LET(0.001)VR 99.669 0.014154 2430400.0 9484.1 11449.0 10984.0 10960.0 10266.0 5582.2 8655.0 10293.0 8016.2 7954.5 True False 8957.011689860405 12327.101485662719 10277.301398474956 9467.229092945438 8976.29330079555 6351.097379833692 9057.474649557147 10322.950925902123 9619.663991342066 7724.832916726955 1.1595087928005994 1.5957758075220305 1.3304237786452335 1.2255577816376568 1.1620048482030916 0.8221663106889151 1.1725139879653006 1.336333230398982 1.2452908813745527 1.0 12.915288013431034 -5.872190091879485 2.499110637197807 1.1299687764311768 1.3917168319055868 0.29843742835537357 0.16355416938445924 0.3604353063663463 4.570624561662132 0.051687988110167414 0.08649060357565015 1.3421773578584691e-06 5.872190091879485 0.26174805547441005 IFSLSGT(ph)LETVR ddPTM_A459_Selumetinib_30min_R1 2 IFSLSGTLETVR 12 0 B4DEM9;Q9Y2S7 B4DEM9 POLDIP2 Polymerase delta-interacting protein 2 1 IFSLS(0.001)GT(0.995)LET(0.004)VR;IFSLS(0.118)GT(0.76)LET(0.122)VR 214.61 3.4356e-06 64939000.0 6130.0 8504.3 6090.299999999999 8138.099999999999 5148.299999999999 6579.3 5382.5 5333.3 3255.8 3659.7999999999997 True False 6272.817073096366 7508.612602458187 5263.270711623249 6716.933606056866 4682.63717400619 6513.118215526436 4976.493691524392 5191.843559000084 5524.8548057764165 4129.570979470844 1.5189996985837386 1.818254884051013 1.2745320852428297 1.626545139785335 1.133928245157858 1.577190039329707 1.2050873362544967 1.2572355784196638 1.3378762184357373 1.0 12.011776192713628 -1.5228787482219681 0.09116864398993034 0.7594718330915632 3.250872680838287 0.472102319718291 0.17412096042328107 125.1843028559249 0.8224639354795453 2.8942942821347253 38.98955241464742 0.029999999796799362 1.5228787482219681 2.4914008477467235 IFTSIGEDYDER ddPTM_A459_Selumetinib_30min_R1 4 IFTSIGEDYDER 12 0 P35232;D6RBK0;C9JZ20;E7ESE2;E9PCW0;C9JW96;P35232-2 P35232 PHB Prohibitin 0 ;;; 251.64 2.3025e-17 41624500.0 5896.2 5994.299999999999 7083.0 6348.2 6768.1 5912.36 5793.500000000001 5404.1 3530.96 5145.3 False True 6033.569987991977 5292.484569325531 6121.167504134033 5239.606040472614 6155.926550005106 5852.887026393369 5356.491630626392 5260.7657130092775 5991.781228885151 5805.74937446618 1.0392405181194624 0.9115937027185501 1.0543285817770691 0.902485743445372 1.0603155859739681 1.0081191331018355 0.9226184744013178 0.9061303500537324 1.0320426946497456 1.0 12.503266578979572 IFTSIGEDYDER ddPTM_A459_Selumetinib_30min_R2 5 IFTSIGEDYDER 12 0 P35232;D6RBK0;C9JZ20;E7ESE2;E9PCW0;C9JW96;P35232-2 P35232 PHB Prohibitin 0 ;;;; 251.64 2.3025e-17 35053900.0 61413.0 51018.399999999994 64200.3 72554.2 73738.0 52613.700000000004 54773.100000000006 58837.59999999999 50665.600000000006 58275.4 False True 57999.9113157176 54931.347229988125 60069.72259400147 62672.192797023876 64474.373213916 59860.75959538462 57320.15768083867 59008.80767491097 60800.13571514439 56592.837784327145 1.0248631025846902 0.9706413281364173 1.061436834514724 1.1074226925298372 1.139267365591827 1.0577444415053259 1.0128518011286747 1.0426903824789804 1.0743432931716743 1.0 15.788331861107402 -3.0288989793089396 12.26581891836997 1.05182884833478 1.0159323616388143 0.0 0.04793526243428152 0.0 0.0 0.012024443450051306 0.0 0.0009356232829881747 3.0288989793089396 -0.03589648669596568 IFTTPLT(ph)PSQYYSGSK ddPTM_A459_Selumetinib_30min_R2 2 IFTTPLTPSQYYSGSK 16 0 P49454 P49454 CENPF Centromere protein F 1 IFT(0.211)T(0.007)PLT(0.563)PS(0.219)QYYSGSK;IFTT(0.001)PLT(0.995)PS(0.004)QYYSGSK 216.01 3.4258e-10 16856800.0 85315.0 70458.0 85796.0 87995.0 88749.0 76300.0 82831.0 82670.0 72682.0 86685.0 True False 80573.53384300473 75861.9020418224 80275.9787676219 76009.92920015828 77599.55719387332 86809.63241756128 86682.80562651274 82910.55601324479 87220.43090475815 84182.17881532169 0.9571329107526002 0.9011634423034801 0.9535982543731828 0.902921856737735 0.9218050457462109 1.0312115181528347 1.0297049428558616 0.9848943942771239 1.0360913928837807 1.0 16.361227229753254 -6.7572743579193455 24.99952184919164 1.0162691354367228 0.9259748803063766 0.800338905866832 0.022235311192440283 43.29187679473004 259849.1052404818 0.007120112470947303 0.006874931889091319 1.7487416027758266e-07 6.7572743579193455 -0.09029425513034617 IFTTPLTPS(ph)QYYSGSK ddPTM_A459_Selumetinib_30min_R1 2 IFTTPLTPSQYYSGSK 16 0 P49454 P49454 CENPF Centromere protein F 1 IFT(0.006)T(0.135)PLT(0.225)PS(0.629)QYYS(0.005)GSK;IFTT(0.007)PLT(0.191)PS(0.801)QYYS(0.001)GSK 162.79 3.6764e-05 28332000.0 5936.5 7316.9 5360.799999999999 5543.0 6029.9 5992.1 6701.700000000001 5865.8 3616.0 6020.8 True False 6074.808899581824 6460.233946465472 4632.832804766586 4575.019104996645 5484.49660966531 5931.824914391497 6196.185373430373 5710.219929196316 6136.087897809298 6793.62832755835 0.894192117478574 0.9509254311513534 0.6819379249779536 0.673427936355906 0.8073000678323028 0.873145339778017 0.9120583397675068 0.8405258065167933 0.9032121867659819 1.0 12.729966576671387 -6.82470449107426 3.6434521930708916 0.8994294181469152 0.7954484993457622 0.2668993487313972 0.08692062746200806 0.38772931049017395 10.34076945703842 0.03495424409540532 0.03138917137818033 1.4972540928264756e-07 6.82470449107426 -0.10398091880115301 IFVEESIYDEFVR ddPTM_A459_Selumetinib_30min_R1 1 IFVEESIYDEFVR 13 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 242.97 6.4608e-17 38148000.0 787.44 1142.5 646.48 638.17 1024.2 624.47 715.57 793.97 416.79 840.78 False True 805.7858199084836 1008.7355688661597 558.69156686045 526.7255894345495 931.5612908371967 618.1883987733944 661.5939787912882 772.9113364219714 707.2621888628141 948.7023028907305 0.8493558173657056 1.0632793509539353 0.5889008229010265 0.5552063991302619 0.9819321487875549 0.6516147340316892 0.697367316149004 0.8147037633058152 0.7455048719790818 1.0 9.88981163895865 -10.875428471184314 4.441755372541498 1.0003054845195256 0.7704882414427638 0.16422383657943118 0.1542829472430136 0.0004779042020299455 6.966144409997211e-05 0.15296107432725292 0.0370495641066082 1.332206440224112e-11 10.875428471184314 -0.22981724307676177 IFVEESIYDEFVRR ddPTM_A459_Selumetinib_30min_R1 2 IFVEESIYDEFVRR 14 1 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 237.07 3.2037e-19 25718000.0 2377.4 2033.59 3483.5 3891.2 2872.7 2491.4 2338.93 1898.4 1458.53 1688.23 False True 2432.7887943848777 1795.496337409657 3010.4598334958205 3211.6749668704574 2612.864792216378 2466.338778010209 2162.502627016655 1848.0482651277382 2475.0188831835726 1904.9307652527639 1.2771008998125308 0.9425520182469276 1.5803513116637415 1.6859798925260692 1.3716324182887976 1.2947130798651112 1.135213240534605 0.9701393346348323 1.2992697311259835 1.0 10.895522848553059 -7.183365731723789 2.785235491204841 1.09348809723293 1.3742678095739025 0.2904966691601897 0.20063565660566257 0.4061303713414387 6.160720900325115 0.09570838847572777 0.06857385168495041 6.555929403269725e-08 7.183365731723789 0.28077971234097254 IFVGGIKEDTEEYNLR ddPTM_A459_Selumetinib_30min_R1 1 IFVGGIKEDTEEYNLR 16 1 P51991;P51991-2 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 111.66 0.0072768 12894000.0 715.6 995.74 1195.6 1139.1 1031.4 784.66 836.99 695.34 522.56 622.18 False True 732.27208768479 879.1582978930325 1033.2440869607017 940.177568555237 938.1100521084594 776.7670328142771 773.8551704354848 676.897324417363 886.746153727662 702.0428635464153 1.0430589437027673 1.2522857841640993 1.4717678087933288 1.3392025150798752 1.3362575147755726 1.1064381865380524 1.1022904876866133 0.9641823306884313 1.2630940356664349 1.0 9.455415307395736 -6.8060708884661745 6.4849335181061 1.084248521923848 1.2994757125981709 0.39443065479867534 0.12440787578551618 0.20529632326580377 21.067335928624434 0.04510395239665261 0.04024220389482183 1.5628925159921164e-07 6.8060708884661745 0.21522719067432283 IFVGGLS(ph)PDTPEEK ddPTM_A459_Selumetinib_30min_R2 2 IFVGGLSPDTPEEK 14 0 D6RAF8;Q14103-3;Q14103;D6RF44;H0YA96;H0Y8G5;Q14103-4;Q14103-2 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 IFVGGLS(0.995)PDT(0.005)PEEK;IFVGGLS(0.945)PDT(0.055)PEEK 85.45 0.024585 3615100.0 28818.7 20610.7 25230.0 26961.8 24622.2 20017.8 22801.0 20334.4 15122.3 25807.6 True False 27217.07202439664 22191.47441615412 23606.729268346993 23289.556328300765 21528.939110739153 22775.070246504052 23861.291679324357 20393.56973745886 18147.182552365477 25062.46753180244 1.085969367934748 0.8854465103244428 0.9419156050134242 0.9292603092152846 0.8590111521708907 0.9087321596568316 0.952072721851754 0.8137095723547936 0.7240780473565913 1.0 14.613240842119982 -1.8815524048232397 1.1394243858731634 0.8823905382368927 199.997827475848 0.36727436277350434 0.0751546326144823 1708.0291386496938 2.9716140183122977 0.023268101141248634 888008.5820506915 0.013135529834705482 1.8815524048232397 199.1154369376111 IFVGGLSPDTPEEK ddPTM_A459_Selumetinib_30min_R2 1 IFVGGLSPDTPEEK 14 0 D6RAF8;Q14103-3;Q14103;D6RF44;H0YA96;H0Y8G5;Q14103-4;Q14103-2 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 193.85 0.0016277000000000002 4246100.0 28369.0 27499.0 29854.0 28919.0 27332.0 25684.0 26768.0 21308.0 20819.0 27871.0 False True 26792.364550104918 29608.08487677867 27933.226142577514 24980.182311942426 23898.309808819784 29221.737863861672 28012.765039785754 21370.002752270702 24983.381731462585 27066.29181244542 0.9898793944793521 1.0939099113371897 1.0320300370711835 0.922925921476108 0.8829547089206746 1.0796358092328389 1.0349687069768876 0.7895430560031318 0.9230441282678743 1.0 14.724209625792774 -5.695648537877286 6.122799018336535 0.9453533536819948 1.0460257104479433 0.21338653456421242 0.07985211046463012 0.31955766568563776 21.992748540412702 0.023209452410528415 0.04029252502554162 2.0153545589872587e-06 5.695648537877286 0.10067235676594855 IFVGNVSAACTS(ph)QELR ddPTM_A459_Selumetinib_30min_R1 2 IFVGNVSAACTSQELR 16 0 Q96PK6;A0A0A6YYI9;F8WDX3;A0A0A0MSL8;B8ZZ74;Q96PK6-3;Q96PK6-4;Q96PK6-2;Q96PK6-5 Q96PK6 RBM14;RBM14-RBM4 RNA-binding protein 14 1 IFVGNVSAACT(0.006)S(0.994)QELR;IFVGNVSAACT(0.013)S(0.987)QELR 63.16 0.032655 10890200.0 8675.5 9331.8 6854.7 6288.7 7327.700000000001 10428.8 10619.0 5872.5 2920.0 3661.6 True False 8877.622270415588 8239.228517763879 5923.8693901719 5190.496598519287 6664.910828810508 10323.895740592776 9818.000280594046 5716.742223431646 4955.026731638038 4131.602027004331 2.1487118585940905 1.9941970363824788 1.4337947729363165 1.2562915219311963 1.6131541192129253 2.4987633545330223 2.376318003627447 1.3836623629446325 1.199299133665771 1.0 12.012485579204169 -5.079150517073686 5.549441371797751 1.6584686613982822 2.1150260289851324 0.13647299204782948 0.46448771131466887 0.47261049164801616 24.51086703110186 0.12960372210893376 0.36950580603143696 8.333922988171533e-06 5.079150517073686 0.45655736758685017 IFYPEIEEVQALDDTER ddPTM_A459_Selumetinib_30min_R1 2 IFYPEIEEVQALDDTER 17 0 P33316-2;A0A0C4DGL3;H0YKC5;P33316;H0YNW5 P33316-2;P33316;H0YNW5 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 ; 217.2 1.332e-10 6302900.0 2796.3 3139.5 3602.4 3922.0 3375.1 3066.8 3618.2 2626.0 1910.04 2420.2 False True 2861.4483493473695 2771.9258804860456 3113.2138665667694 3237.096325058064 3069.8228009223017 3035.9507764316063 3345.276260970467 2556.3499495498513 3241.198376197919 2730.8562447443405 1.0478209370611724 1.015039105709334 1.1400138226090422 1.185377784454237 1.1241246428955454 1.1117211981679498 1.2249917099842242 0.9360983224472783 1.1868798961628815 1.0 11.415137655721312 -10.487891585385993 12.214479857958661 1.0000000058832856 1.1074579071936355 0.13201671082215216 0.08307304503796546 0.0 0.0 0.07911605600448197 0.019188462093456562 3.2516846031698016e-11 10.487891585385993 0.10745790131034982 IGAEVYHNLK ddPTM_A459_Selumetinib_30min_R1 2 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;P06733-2;K7EM90 P06733 ENO1 Alpha-enolase;Enolase 0 ; 137.46 0.0024502 140793000.0 16454.4 19030.6 20663.7 22490.5 19990.2 16643.7 17367.7 18802.6 10537.8 15012.2 False True 16837.75550531108 16802.488504914087 17857.68303757933 18562.956373972036 18182.089939556452 16476.27948927049 16057.640406184508 18303.893968547625 17881.87694953949 16939.16210121106 0.9940134821726083 0.9919315019550347 1.054224697235916 1.0958603656461192 1.0733759929162334 0.9726738188598198 0.9479595454745943 1.0805666690703075 1.05565297992284 1.0 14.048074892807245 -6.7505858983537115 24.999778643967282 1.0124428228660949 1.0427908064200369 0.0983250240308784 0.04609873498240847 634.8761869679935 1462364.00383685 0.017186439687782572 0.01702335267472645 1.775881984926383e-07 6.7505858983537115 0.03034798355394197 IGAEVYHNLK ddPTM_A459_Selumetinib_30min_R2 4 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;P06733-2;K7EM90 P06733 ENO1 Alpha-enolase;Enolase 0 ;;; 126.31 0.0061081 7776100.0 300399.0 249681.0 292399.0 336471.0 325914.0 231722.0 238302.0 240945.0 231462.0 275250.0 False True 283704.0261724755 268830.7298490481 273586.3666799602 290643.0693551501 284969.769611872 263639.6021371185 249383.51518645458 241646.11005940818 277760.8675886344 267302.81731461413 1.061358159343892 1.005716036029039 1.0235072320915735 1.0873176432445326 1.0660934010151637 0.9862956357351669 0.9329625392347862 0.9040163230864562 1.0391243548387716 1.0 18.02811551779559 -6.904956527413561 4.76737633526351 0.960814786744274 1.0467932041608214 0.47146380803104393 0.04023977031651391 0.1812131422819346 7.049492404141288 0.014781897576094057 0.012964707382171403 1.2446391930847105e-07 6.904956527413561 0.08597841741654744 IGAVLFT(ph)VVT(ph)PMMNPFIY(ph)SLR ddPTM_A459_Selumetinib_30min_R1 1 IGAVLFTVVTPMMNPFIYSLR 21 0 A0A286YFI5;Q8NGQ3 A0A286YFI5 OR1S2 Olfactory receptor 1S2 3 IGAVLFT(1)VVT(1)PMMNPFIY(0.745)S(0.255)LR 60.334 0.006194699999999999 1648500.0 172.94 153.96 0.0 128.55 0.0 142.55 0.0 75.325 65.62899999999999 0.0 True False 176.96916551733867 135.93429162593785 0.0 106.10115568235946 0.0 141.1160764250442 0.0 73.32713630991721 111.36761964749067 0.0 0.0 IGDELDSNMELQR ddPTM_A459_Selumetinib_30min_R1 1 IGDELDSNMELQR 13 0 K4JQN1;Q07812-5;Q07812-7;Q07812-8;Q07812;Q07812-2 K4JQN1 BAX Apoptosis regulator BAX 0 183.85 0.017986000000000002 5155800.0 568.09 464.31 440.08 555.78 513.42 365.28 488.75 353.01 191.7 442.28 False True 581.3253916892851 409.94836934813696 380.3195531864048 458.72345628270506 466.98125165166323 361.6056148477035 451.88319400511756 343.6470280619165 325.30089878596294 499.0509461720218 1.1648618165106204 0.8214559505249964 0.7620856269357907 0.9191916372493643 0.9357386359722396 0.724586573017054 0.9054850962036938 0.6886010951344076 0.6518390582788965 1.0 8.963043291986452 -4.761566549534803 8.263776516228626 0.8173479281639395 1.1685622118005417 0.4637165170475773 0.1100664047764614 0.08054348515201329 54.61188131503871 0.02734331160660853 0.1584638016835536 1.7315436756504968e-05 4.761566549534803 0.3512142836366021 IGDEYAEDS(ph)SDEEDIR ddPTM_A459_Selumetinib_30min_R2 2 IGDEYAEDSSDEEDIR 16 0 Q14137;Q14137-2;A0A075B729 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 IGDEYAEDS(0.959)S(0.041)DEEDIR;IGDEYAEDS(0.96)S(0.04)DEEDIR 201.4 5.3394000000000006e-14 3171200.0 21378.0 18714.5 17302.300000000003 21681.0 22713.0 16603.6 19242.5 18900.7 19261.3 19633.0 True False 20189.896342914533 20149.84197339811 16189.088855319864 18728.010398188864 19859.58988320371 18890.59518752583 20137.31437829038 18955.697907820675 23114.098205688097 19066.14427733992 1.0589396602285335 1.0568388490244545 0.8491013505316105 0.982265219740683 1.0416154202088357 0.9907926276408843 1.056181789320851 0.9942071995306092 1.2123110928704741 1.0 14.218725498271702 -8.199755674268122 24.997591172067814 1.1061569771837 1.0022206610138606 0.22651472511844917 0.07565746316422657 287.45453993797673 116492.12309604924 0.05054134681354517 0.019102824976650026 6.313124088271068e-09 8.199755674268122 -0.10393631616983945 IGEEQS(ph)AEDAEDGPPELLFIHGGHTAK ddPTM_A459_Selumetinib_30min_R1 2 IGEEQSAEDAEDGPPELLFIHGGHTAK 27 0 E9PC52;Q16576;Q16576-2;Q5JNZ6 E9PC52 RBBP7 Histone-binding protein RBBP7 1 IGEEQS(1)AEDAEDGPPELLFIHGGHTAK;IGEEQS(1)AEDAEDGPPELLFIHGGHTAK 137.25 1.9823e-12 10146500.0 1830.63 2062.9700000000003 2255.2 2099.67 1620.3200000000002 1751.54 1883.41 1877.47 1115.8600000000001 1736.17 True False 1873.2801172140958 1821.436513351266 1948.9562269268768 1733.002050187318 1473.7623420907303 1733.9210978710764 1741.3428673579108 1827.6733967179603 1893.532920810144 1959.0243312279063 0.9562311643367561 0.9297671725238854 0.9948606537751785 0.8846250771684298 0.7522940468876074 0.8850942125789033 0.888882715543633 0.932950840673012 0.9665693736551437 1.0 10.935919600758577 -10.133808206726982 9.01912824334416 0.9999999988266337 0.9071264850170087 0.15189368489702204 0.06333968928713442 0.0 0.0 0.06731330209417953 0.016325873796671338 7.34838316051099e-11 10.133808206726982 -0.09287351380962505 IGEEQSPEDAEDGPPELLFIHGGHTAK ddPTM_A459_Selumetinib_30min_R1 1 IGEEQSPEDAEDGPPELLFIHGGHTAK 27 0 Q09028-3;Q09028;Q09028-4;Q09028-2;H0YEU5;H0YCT5;H0YF10;H0YDK2 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 72.082 0.00023627 2750100.0 1768.7 2289.4 1728.0 1800.5 1712.5 2085.1 1862.4 2131.5 1093.2 1599.6 False True 1809.9072687088985 2021.3559836868158 1493.3470912245664 1486.0764745708918 1557.6046773664307 2064.125787119325 1721.9176685731575 2074.965695912227 1855.080555831062 1804.9242414234557 1.002760795811304 1.119911815297395 0.8273738348413097 0.8233456233037769 0.8629750997958916 1.1436079918187867 0.9540110488045553 1.149613733524795 1.0277885981342079 1.0 10.817722568413636 -6.755597077256303 24.999706902041112 1.058043057455657 0.9266518235419259 0.2925061115597012 0.09926660693912336 199.2392141106965 852559.9798323398 0.035510862614653145 0.03459323311327095 1.7555084439181857e-07 6.755597077256303 -0.1313912339137311 IGEGT(ph)Y(ph)GVVYK ddPTM_A459_Selumetinib_30min_R1 3 IGEGTYGVVYK 11 0 A0A087WZZ9;P06493;E5RIU6;A0A024QZP7;P06493-2;G3V317;K7ELV5;E7ESI2;P24941-2;G3V5T9;P24941;Q00526 A0A087WZZ9;G3V5T9 CDK1;CDC2;CDK2;CDK3 Cyclin-dependent kinase 1;Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 2 IGEGT(1)Y(0.994)GVVY(0.006)K;IGEGT(1)Y(0.961)GVVY(0.039)K;IGEGT(1)Y(1)GVVYK 116.24 0.0056582 0.0 7361.6 10309.3 8015.9 9665.8 5713.629999999999 8700.8 5860.2 5527.74 4752.35 4630.05 True False 7533.110956819939 9102.28236333646 6927.384808186925 7977.849479537531 5196.833175323306 8613.27785169432 5418.160395925914 5381.126378569953 8064.390852089049 5224.362018006169 1.4419197848189862 1.7422763453154162 1.3259771785169472 1.527047599695667 0.9947306785808521 1.6486755362679673 1.0370951280274612 1.03000641227072 1.5436125644230818 1.0 12.351039155414396 -1.5228787473026082 0.1513978823829622 0.9968234693084377 3.268782371485936 0.263789844704713 0.2374136739433538 86.03183981194265 0.8550391539757609 0.7896666824632258 43.00086798391177 0.029999999860306496 1.5228787473026082 2.2719589021774986 IGEGT(ph)YGVVYK ddPTM_A459_Selumetinib_30min_R1 1 IGEGTYGVVYK 11 0 A0A087WZZ9;P06493;E5RIU6;A0A024QZP7;P06493-2;G3V317;K7ELV5;E7ESI2;P24941-2;G3V5T9;P24941;Q00526 A0A087WZZ9;G3V5T9 CDK1;CDC2;CDK2;CDK3 Cyclin-dependent kinase 1;Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 IGEGT(1)YGVVYK 134.99 0.0035889000000000008 9025800.0 2616.1 3074.1 1552.9 2830.4 1470.9 2552.7 1505.3 984.4 1511.2 1041.7 True False 2677.050039955533 2714.182942889683 1342.0247094691151 2336.1237731882557 1337.8573547084868 2527.0221556661545 1391.754009076017 958.2905142181544 2564.396026318974 1175.4123420172625 2.277541203422396 2.3091325876598816 1.141748015990635 1.987492975596088 1.1382025752872675 2.149902689748209 1.184055977060327 0.8152802892757788 2.1816990809522334 1.0 10.198951236709188 -1.5228787457457358 0.4441725327092099 1.3669566492346252 24.017102392420636 0.276795574882979 0.4901124417884072 109.83930763669555 1.3402557106128423 0.2983583605282737 2247.8235875914042 0.02999999996785143 1.5228787457457358 22.65014574318601 IGEGTY(ph)GVVYK ddPTM_A459_Selumetinib_30min_R1 6 IGEGTYGVVYK 11 0 A0A087WZZ9;P06493;E5RIU6;A0A024QZP7;P06493-2;G3V317;K7ELV5;E7ESI2;P24941-2;G3V5T9;P24941;Q00526 A0A087WZZ9;G3V5T9 CDK1;CDC2;CDK2;CDK3 Cyclin-dependent kinase 1;Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 IGEGT(0.149)Y(0.851)GVVYK;IGEGT(0.149)Y(0.851)GVVYK;IGEGT(0.029)Y(0.97)GVVY(0.001)K;IGEGT(0.158)Y(0.842)GVVYK;IGEGT(0.273)Y(0.727)GVVYK;IGEGT(0.011)Y(0.989)GVVYK 185.81 0.0002663 3566425000.0 16459.8 17923.0 21958.1 22735.3 18790.0 16147.4 17726.5 18738.9 10147.85 14679.5 True False 16843.2813148045 15824.566827823355 18976.310627209587 18765.00664943717 17090.447817643944 15984.971816666148 16389.37583331298 18241.883499474385 17220.16028036063 16563.756815438614 1.0168756703253061 0.9553730475609084 1.1456525737882302 1.1328955658143227 1.0317977985353188 0.9650571422158893 0.989472135816248 1.1013131684275657 1.0396289001484373 1.0 14.015742306270132 -6.5042437990984725 24.72905965227451 1.0207807908362245 1.0636318474842097 0.10351074118422032 0.06065384020107082 1843.398019024862 2446240.8589138677 0.020977617803778693 0.023380088417517694 3.1315272910533873e-07 6.5042437990984725 0.042851056647985164 IGEGTY(ph)GVVYK ddPTM_A459_Selumetinib_30min_R2 6 IGEGTYGVVYK 11 0 A0A087WZZ9;P06493;E5RIU6;A0A024QZP7;P06493-2;G3V317;K7ELV5;E7ESI2;P24941-2;G3V5T9;P24941;Q00526 A0A087WZZ9;G3V5T9 CDK1;CDC2;CDK2;CDK3 Cyclin-dependent kinase 1;Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 IGEGT(0.015)Y(0.983)GVVY(0.002)K;IGEGT(0.147)Y(0.612)GVVY(0.241)K;IGEGT(0.158)Y(0.841)GVVY(0.001)K;IGEGT(0.047)Y(0.952)GVVY(0.001)K;IGEGT(0.024)Y(0.976)GVVYK;IGEGT(0.025)Y(0.975)GVVYK 182.39 0.0005137000000000001 2636748000.0 763528.0 673598.0 784374.0 816175.0 802329.0 621310.0 654354.0 742236.0 568191.0 685498.0 True False 721094.1704047541 725260.8006410548 733908.2308018404 705010.5570195947 701533.2581077332 706889.8128093713 684782.7575778533 744395.7838762159 681845.0765829977 665705.8916023007 1.083202326284267 1.0894612918257494 1.1024511575755807 1.0590420873738864 1.0538186111275039 1.0618650393914109 1.028656597780194 1.1182051913113087 1.0242437166086231 1.0 19.344525410828403 -7.605985033476816 0.009355162616454488 1.6377662623176136e-07 2.1134581710944205 0.44719440318647363 0.026240614659501716 1298.352524090971 10.26343468311971 1150.1630324577077 1166.9051958609364 2.4775074352632246e-08 7.605985033476816 2.1134580073177944 IGEGTYGVVYK ddPTM_A459_Selumetinib_30min_R1 3 IGEGTYGVVYK 11 0 A0A087WZZ9;P06493;E5RIU6;A0A024QZP7;P06493-2;G3V317;K7ELV5;E7ESI2;P24941-2;G3V5T9;P24941;Q00526 A0A087WZZ9;G3V5T9 CDK1;CDC2;CDK2;CDK3 Cyclin-dependent kinase 1;Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 0 ;; 175.73 0.0010302999999999998 69872000.0 4757.5 5561.799999999999 6534.599999999999 6698.200000000001 5567.6 5334.5 5270.0 5154.1 2857.14 4693.2 False True 4868.34049351647 4910.62187038933 5647.237211988459 5528.4851107863105 5064.011563039616 5280.839773338464 4872.47965709866 5017.396525123723 4848.357902750789 5295.617935639258 0.9193149038854879 0.9272991235529054 1.0663981579907456 1.0439735603997917 0.9562645237223513 0.9972093601765835 0.9200965243937073 0.9474619555457131 0.9155414838599988 1.0 12.370583324057607 -7.252292476814096 24.41905949732659 0.9413968202248606 0.9875142857125568 0.13340601975462552 0.04832307854695951 931.3691694351775 2486438.123964594 0.01989078223363981 0.015182247633661033 5.5938075810517875e-08 7.252292476814096 0.04611746548769624 IGEGTYGVVYK ddPTM_A459_Selumetinib_30min_R2 2 IGEGTYGVVYK 11 0 A0A087WZZ9;P06493;E5RIU6;A0A024QZP7;P06493-2;G3V317;K7ELV5;E7ESI2;P24941-2;G3V5T9;P24941;Q00526 A0A087WZZ9;G3V5T9 CDK1;CDC2;CDK2;CDK3 Cyclin-dependent kinase 1;Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 0 ; 152.97 0.0078786 14532700.0 50321.0 48744.0 54340.0 54854.0 57385.0 40901.0 40094.0 54248.0 40538.0 40748.0 False True 47524.36027092351 52482.508063336805 50843.82356091857 47382.79057157201 50175.78327159095 46534.741487689054 41958.45044475377 54405.85269876016 48646.73272635717 39571.499363981406 1.2009744648235625 1.326270394270357 1.2848596686532785 1.1973968975939426 1.2679778142867575 1.1759660926582352 1.0603199555017369 1.3748746843866424 1.2293376169273027 1.0 15.272174109606071 -6.271194205787803 1.3808326616045075 1.1888420975754228 1.2712735277198237 0.12718866490178637 0.10144708563187828 1.0582991402486952 4.070892448524316 0.03945582295399023 0.05481894627276475 5.355571160169525e-07 6.271194205787803 0.08243143014440091 IGEHMEEHGIK ddPTM_A459_Selumetinib_30min_R1 4 IGEHMEEHGIK 11 0 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 ;;; 125.74 0.0018571 30978800.0 23357.2 25165.800000000003 26639.800000000003 25336.3 22788.4 22502.600000000002 22178.8 21541.0 13492.8 18831.9 False True 23901.37731480041 22219.376436736973 23022.261481946894 20911.790826254106 20727.193243618804 22276.244274726076 20505.83525974568 20969.662704970826 22896.296124878674 21249.15780323979 1.1248152767332853 1.0456591570584157 1.0834434802134496 0.9841232777266002 0.9754359883599056 1.0483353966776834 0.9650187291949625 0.9868467681939682 1.0775154637605333 1.0 14.37511804163896 -5.753735182621914 24.996684544455896 1.0036443221760236 1.0807413153581515 0.4915165191870686 0.03687678228316666 148.12407558505555 480590.83454262285 0.009866200628370781 0.016677164364923208 1.7630507645668681e-06 5.753735182621914 0.07709699318212793 IGEHMEEHGIK ddPTM_A459_Selumetinib_30min_R2 2 IGEHMEEHGIK 11 0 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 ; 129.88 0.0014107000000000002 35785000.0 283570.0 245030.0 266910.0 291000.0 278010.0 213580.0 229280.0 238080.0 199565.0 252380.0 False True 267810.3146206506 263823.0131043699 249737.30118963457 251365.29799699975 243083.898359066 242998.7063137974 239941.9743097007 238772.77338373408 239483.5763119903 245093.13363800992 1.0926879535360334 1.076419437739219 1.0189485828619085 1.0255909427811776 0.9918021559840535 0.9914545654824182 0.9789828492873357 0.9742124140302898 0.9771125480230521 1.0 17.902970541647882 -5.092132245815294 0.6796289618592789 0.9801148644151234 1.1432346851510133 0.9321574313584451 0.010286741096174027 0.48852273028886517 0.22548568241342 0.004648401089582502 0.05775141413178294 8.088495611246409e-06 5.092132245815294 0.16311982073588993 IGEHTPS(ph)ALAIMENANVLAR ddPTM_A459_Selumetinib_30min_R1 1 IGEHTPSALAIMENANVLAR 20 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 IGEHT(0.493)PS(0.507)ALAIMENANVLAR 72.899 0.0053217 9230900.0 1110.9 2083.6 1905.5 2477.9 1883.1 1459.3 1881.5 2059.3 591.61 1304.6 True False 1136.7818085648871 1839.6511433606402 1646.743566162275 2045.1812809437467 1712.7739374883083 1444.6207669383866 1739.5769401956604 2004.6806744508792 1003.9189605151989 1472.0581178801197 0.7722397606162065 1.2497136634862511 1.1186674942791772 1.3893346030990745 1.1635233124863564 0.9813612311847816 1.1817311552214997 1.361821690394791 0.6819832371570504 1.0 10.523618915786807 -8.266386322352563 24.998396975594417 0.8409916259071011 1.1579836730051805 0.3152835268731271 0.18335463581922026 511.7211137658356 2585834.878987899 0.15410935451160512 0.044647223964155484 5.415189732548293e-09 8.266386322352563 0.3169920470980794 IGEHTPS(ph)ALAIMENANVLAR ddPTM_A459_Selumetinib_30min_R2 2 IGEHTPSALAIMENANVLAR 20 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 IGEHT(0.047)PS(0.953)ALAIMENANVLAR;IGEHT(0.002)PS(0.998)ALAIMENANVLAR 96.777 0.00064553 2619800.0 11837.3 11396.2 14387.8 9761.099999999999 12104.0 7726.4 8328.2 10908.7 7425.3 14320.0 True False 11179.430254466377 12270.251895441474 13462.104612252184 8431.621341163296 10583.387308867073 8790.64146672406 8715.477802015233 10940.442510967501 8910.567480216587 13906.544392171725 0.8038970673950823 0.8823365136164701 0.9680409620545471 0.6063060026550972 0.7610364595553066 0.6321226336912634 0.6267177205374868 0.7867117957158428 0.6407463442343394 1.0 13.763476351720751 -5.758072878473939 24.99951967886641 0.706979644795057 0.8845160129886194 0.2857911820072724 0.11627059707525977 96.39778387669827 715831.886294567 0.029863140711834966 0.04914443003372121 1.7455292130265594e-06 5.758072878473939 0.17753636819356233 IGEHTPSALAIMENANVLAR ddPTM_A459_Selumetinib_30min_R1 4 IGEHTPSALAIMENANVLAR 20 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;;; 183.73 1.7843e-12 97444000.0 9505.3 10105.400000000001 11939.199999999999 11227.1 11207.5 10806.2 10969.2 9202.6 6365.0 7753.5 False True 9726.754995905858 8922.255070126992 10317.922217331214 9266.497743768328 10193.783603844837 10697.499439244566 10141.784412646415 8958.517153742378 10800.940118793194 8748.737250485596 1.111789589448006 1.0198334702110028 1.1793613091716202 1.0591811684885146 1.165171991338411 1.2227478243961212 1.1592283688807203 1.0239783064973333 1.234571322643584 1.0 13.094859085158129 -2.8601434581826637 20.055748647835674 1.1210303284096632 1.1074698940601406 0.0 0.08262386802915317 0.0 0.0 0.018148826730700836 0.0 0.0013799283649238473 2.8601434581826637 -0.013560434349522588 IGEHTPSALAIMENANVLAR ddPTM_A459_Selumetinib_30min_R2 1 IGEHTPSALAIMENANVLAR 20 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 92.671 0.0019189 49032000.0 47567.0 37926.0 38204.0 48150.0 59811.0 47371.0 40204.0 36664.0 30345.0 49831.0 False True 44923.41656578802 40834.80224868934 35745.99623337014 41591.88693661705 52297.00746287578 53895.92525887681 42073.56566271466 36770.68616994804 36414.84791014133 48392.24955351325 0.9283184183473572 0.8438293864296035 0.7386719270787651 0.8594741372918363 1.080689737414347 1.1137305199932372 0.8694277709943771 0.7598465975276926 0.7524933898737848 1.0 15.56248838518829 -2.915780480236757 15.657585450549629 0.891808770321742 88.72190896112856 0.0 0.12731289063735546 0.0 0.0 0.03233347613795366 0.0 0.00121400232858614 2.915780480236757 87.83010019080682 IGELGAPEVWGLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 5 IGELGAPEVWGLSPK 15 0 Q8N5F7;A0A494C050 Q8N5F7 NKAP NF-kappa-B-activating protein 1 IGELGAPEVWGLS(1)PK;IGELGAPEVWGLS(1)PK;IGELGAPEVWGLS(1)PK;IGELGAPEVWGLS(1)PK;IGELGAPEVWGLS(1)PK 159.69 8.8654e-05 1052602000.0 22141.43 28387.98 21394.57 21578.66 18237.25 21621.42 23652.699999999997 22765.510000000002 16260.59 22945.199999999997 True False 22657.282239277025 25064.30210438615 18489.304905960867 17810.352112615354 16587.69395754801 21403.928145478636 21868.557796101977 22161.694722001772 27593.033603495263 25890.439925174716 0.8751215624283807 0.9680910087593658 0.7141363746385277 0.687912301377983 0.6406879916095544 0.8267116436544751 0.8446576365370277 0.8559798437589592 1.0657614811969658 1.0 14.660131858981206 -8.044498016375938 1.9288429984801014 1.0352277299731076 0.7850679899140695 0.5009683743057476 0.09284414700198512 0.3244016532858842 2.169685875661211 0.09026015806157016 0.029266470942396677 9.026138301170092e-09 8.044498016375938 -0.2501597400590382 IGELGAPEVWGLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 IGELGAPEVWGLSPK 15 0 Q8N5F7;A0A494C050 Q8N5F7 NKAP NF-kappa-B-activating protein 1 IGELGAPEVWGLS(1)PK;IGELGAPEVWGLS(1)PK;IGELGAPEVWGLS(1)PK 161.99 0.00011564 254330000.0 582897.9 465975.3 512474.9 458354.5 441109.6 355196.9 490914.9 450585.8 278136.7 435692.1 True False 550502.7682431736 501714.1071632578 479502.8228744815 395925.8263943858 385693.4684781415 404122.0488185754 513743.41557942005 451896.93007950496 333771.811788717 423112.53700897575 1.3010788385868497 1.1857698916461428 1.1332749113607794 0.9357459109891295 0.9115623734636811 0.9551171697141239 1.2142004092129317 1.0680301115017978 0.7888487874837812 1.0 18.690681908447573 -5.371903950403276 2.0144015330976046 0.9914645881700498 1.269149966044225 0.4947808504714688 0.10723551944961031 0.3313867863745825 2.5122146645933854 0.03262168735730677 0.10569518919073284 4.247134842006862e-06 5.371903950403276 0.27768537787417513 IGENPFTLIR ddPTM_A459_Selumetinib_30min_R1 1 IGENPFTLIR 10 0 H3BPR7 H3BPR7 TYRO3 0 109.66 0.011566 0.0 2453.7 2925.9 3053.3 2660.2 1857.1 2809.2 2393.7 2452.5 1626.2 2119.2 False True 2510.8664359309228 2583.3342677859923 2638.6786305763726 2195.646008138565 1689.1256328976356 2780.941998549521 2213.1412818210747 2387.451733157278 2759.542627051294 2391.219962756056 1.050035745367802 1.0803415444928415 1.103486367492141 0.9182116418967674 0.7063865554847555 1.1629804208159429 0.925528105440483 0.9984241392856077 1.154031276934774 1.0 11.223531130973129 -10.570811466232861 15.00238396651831 1.000000133741416 1.0056951811541648 0.0 0.12944580965262095 0.0 0.0 0.12800100143261775 0.031044802887736502 2.686510447145701e-11 10.570811466232861 0.005695047412748844 IGEVS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 3 IGEVSSPK 8 0 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 IGEVS(0.614)S(0.386)PK;IGEVS(0.934)S(0.066)PK;IGEVS(0.631)S(0.369)PK 93.598 0.023839 94589000.0 21685.6 34609.3 26197.2 27419.6 20729.4 26663.300000000003 24560.4 23063.1 16048.000000000002 26592.300000000003 True False 22190.832287167806 30557.22706657296 22639.76413091911 22631.28158963845 18854.42943007282 26395.0914103394 22707.78925430852 22451.39166849322 27232.283900454553 30005.680735937098 0.7395543691361872 1.0183813970257733 0.7545159308385228 0.7542332329935609 0.6283619957167416 0.8796698079482869 0.7567830056630556 0.7482380375261314 0.9075709409864875 1.0 14.872948040061113 -8.4853446632499 3.770846040328473 0.9991412463933496 0.7882047145545792 0.3440580321493242 0.09716279489647746 0.2288172676157692 7.49196264334543 0.09500010393057579 0.024993148128644987 3.2708101497167492e-09 8.4853446632499 -0.21093653183877037 IGEVSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 IGEVSSPK 8 0 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 IGEVS(0.052)S(0.948)PK;IGEVS(0.059)S(0.941)PK;IGEVS(0.143)S(0.857)PK 97.472 0.020242 72140000.0 1245340.0 1071410.0 1015520.0 912660.0 888330.0 740700.0 1006840.0 987090.0 672375.0 872260.0 True False 1176128.9882910103 1153583.7018738664 950182.5488145761 788354.1335736829 776730.0436290386 842724.7015948576 1053660.055015611 989962.2684784526 806868.7877271812 847075.5873963479 1.3884581326515053 1.3618426962576398 1.1217210871761132 0.9306774333998258 0.9169548210171774 0.9948636392475156 1.2438796143969169 1.1686823268290552 0.9525345786522427 1.0 19.69213118625673 -5.321115710010963 3.3931867468005574 1.03882033518865 1.3843865656853893 0.6548957205067814 0.09865088455098836 0.16046726111082324 3.6563388160258334 0.029881003711137475 0.0753557149550435 4.774020614558264e-06 5.321115710010963 0.3455662304967393 IGFPS(ph)TSPAK ddPTM_A459_Selumetinib_30min_R1 1 IGFPSTSPAK 10 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 IGFPS(0.405)T(0.405)S(0.189)PAK 108.47 0.01066 80435000.0 6160.8 6536.4 7363.0 7848.1 5961.2 5422.6 6108.2 5391.5 3302.5 5335.3 True False 6304.33465317 5771.115249310078 6363.145042063939 6477.576662082659 5422.010512535338 5368.053567326865 5647.453556259965 5248.499905939842 5604.101294943364 6020.137725222906 1.047207712002398 0.9586350865579895 1.0569766560993974 1.0759847959861775 0.9006455931761228 0.8916828505161988 0.938093747024842 0.8718238926577893 0.9308925394619378 1.0 12.555580777165877 -6.270964808701436 24.781623803448493 0.9150508129772609 1.030858892930195 0.6145992309221142 0.04338489465771717 382.81077137577125 995929.7511089536 0.013164886989676364 0.015119408669265559 5.358400753896569e-07 6.270964808701436 0.11580807995293407 IGFPS(ph)TSPAK ddPTM_A459_Selumetinib_30min_R2 2 IGFPSTSPAK 10 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 IGFPS(0.478)T(0.045)S(0.478)PAK;IGFPS(0.579)T(0.048)S(0.373)PAK 133.91 0.0021906 107929000.0 316220.0 297060.0 324700.0 319000.0 311400.0 239850.0 293550.0 269450.0 212830.0 289170.0 True False 298645.75832895667 319843.5468015523 303809.15550662915 275551.6496943061 272279.1480486785 272887.1603584807 307200.6566582896 270234.05489015096 255401.94696705838 280820.9107461103 1.063474075116015 1.1389591535465187 1.0818608724665182 0.9812362226238623 0.9695828822905769 0.9717480070606191 1.0939379686580006 0.9623003293172462 0.909483365353682 1.0 18.09929084137022 -5.705241732978634 4.609697392478641 0.9857074739227699 1.102712183228146 0.543570380280516 0.04659928528421762 0.1590073339974459 6.880382523876266 0.013409465792544059 0.023348118523610913 1.971325169897213e-06 5.705241732978634 0.11700470930537599 IGFPSTS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 IGFPSTSPAK 10 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 IGFPS(0.125)T(0.125)S(0.75)PAK 120.63 0.0050284 95880000.0 5628.8 6451.1 7401.9 7907.0 5708.8 5492.7 5812.6 5413.4 3527.9 5464.1 True False 5759.940088261802 5695.802212964976 6396.762635726346 6526.19088277259 5192.440047970504 5437.448424972574 5374.150902248894 5269.81904679862 5986.588632378709 6165.47045984115 0.9342255592301068 0.9238228047745323 1.0375141163017032 1.058506552789604 0.8421806708492906 0.8819194675231105 0.8716530128971466 0.8547310511215058 0.9709865080649418 1.0 12.589995269182117 -6.268834135400311 24.993900580341087 0.8936357844051914 0.9873960020441799 0.31403639262156624 0.0604279671850144 648.4178337474779 2191615.0532374666 0.019007019950612887 0.021989591052226143 5.384753963489872e-07 6.268834135400311 0.09376021763898845 IGGIGT(ph)VPVGR ddPTM_A459_Selumetinib_30min_R1 1 IGGIGTVPVGR 11 0 P68104;A0A087WVQ9;Q5VTE0;A0A2U3TZH3;Q05639 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 IGGIGT(1)VPVGR 99.732 0.039675 11886000.0 1654.4 2048.9 2033.3 2245.5 1938.3 1642.3 1856.1 2015.4 946.69 1409.9 True False 1692.9443010979824 1809.0138354922308 1757.189028117426 1853.3655782554501 1762.9811072346592 1625.7799530890923 1716.0928826453178 1961.9450450581764 1606.4637864980873 1590.8743985889782 1.0641596235375557 1.137119207585923 1.1045429040004415 1.1649980538371147 1.1081837188393568 1.0219411127183098 1.078710477814843 1.2332494927307387 1.0097992575170838 1.0 10.6356042223513 -6.5361847062277105 24.92608906525047 1.081843657742816 1.1204564637815018 0.09670079226320116 0.06640392637792669 679.5674877987592 1273024.8403470786 0.021809409931202714 0.021821472769545543 2.9094794480283615e-07 6.5361847062277105 0.038612806038685665 IGGIGTVPVGR ddPTM_A459_Selumetinib_30min_R1 1 IGGIGTVPVGR 11 0 P68104;A0A087WVQ9;Q5VTE0;A0A2U3TZH3;Q05639 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 148.52 0.0089665 32877000.0 2009.4 2190.6 2314.0 2563.8 2514.1 2034.6 2105.8 1915.0 1526.2 1989.8 False True 2056.215110388228 1934.123533617688 1999.7715098921565 2116.0804584864495 2286.700098900407 2014.1337712689926 1946.9578106106935 1864.2079792033376 2589.8499307623188 2245.2102122933184 0.9158229813536943 0.8614442972990587 0.8906834197273386 0.9424865640197796 1.0184792882109286 0.8970802645742921 0.8671605892180663 0.8303044271739639 1.1534999781231958 1.0 11.132634811158766 -8.26100857679022 24.999999858325467 1.0767499916719774 0.9049239968334354 0.5774151384162732 0.05945976191889343 27.9399774106826 1621657.160662117 0.0479657033491987 0.015604470056562883 5.4826613722151e-09 8.26100857679022 -0.171825994838542 IGHHS(ph)TSDDSSAYR ddPTM_A459_Selumetinib_30min_R1 2 IGHHSTSDDSSAYR 14 0 F5H5P2;P12694;P12694-2;F5GXU9 F5H5P2 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1 IGHHS(0.86)T(0.121)S(0.018)DDSS(0.001)AYR;IGHHS(0.818)T(0.165)S(0.016)DDS(0.001)SAYR 120.54 0.0013568 26756300.0 5110.8 6411.5 4969.3 5427.6 5976.299999999999 5257.2 6270.7 5465.5 1887.65 4352.2 True False 5229.871696114343 5660.838599374514 4294.496354411017 4479.7715486703555 5435.744720201462 5204.31734115568 5797.696050430467 5320.537185553965 3203.2041814988165 4910.847264017982 1.0649632161101545 1.1527213727154082 0.8744919407037971 0.9122196858969451 1.1068853148884163 1.059759561102209 1.180589771730526 1.0834255067425538 0.6522711885113696 1.0 12.26175623754138 -8.235422896956797 24.884185729683754 0.8261355318698936 1.053061240062128 0.3692157546630147 0.11932402882777927 657.9406869597583 629307.6600576006 0.081584632149352 0.030812460253128095 5.815366670228102e-09 8.235422896956797 0.22692570819223434 IGHHS(ph)TSDDSSAYR ddPTM_A459_Selumetinib_30min_R2 3 IGHHSTSDDSSAYR 14 0 F5H5P2;P12694;P12694-2;F5GXU9 F5H5P2 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1 IGHHS(0.493)T(0.493)S(0.013)DDSSAYR;IGHHS(0.971)T(0.024)S(0.006)DDSSAYR;IGHHS(0.975)T(0.024)S(0.001)DDSSAYR 123.76 0.001046 31451300.0 59280.0 31680.2 62506.0 85715.0 66758.0 53281.0 88027.0 75675.0 77187.0 55802.0 True False 55985.45491664203 34109.96947210166 58484.43201138707 74040.46913337766 58371.26321590773 60619.97411323834 92120.42992219151 75895.2017213293 92626.55678497539 54190.85126899211 1.0331163583081926 0.6294414771745671 1.0792307306833495 1.366290940252187 1.0771423930243305 1.1186385283437126 1.6999258687582681 1.400516875894813 1.7092655792616438 1.0 15.725761689746047 -5.927370849064888 0.7146641371237477 1.4475372887304336 0.7829796667342852 0.38261551713951725 0.24915871421825217 0.9101159488216707 0.8770111263436128 0.13579844988838494 0.3882602567643927 1.1820317740954076e-06 5.927370849064888 -0.6645576219961484 IGPALSCGNTVVVKPAEQTPLTALHVASLIK ddPTM_A459_Selumetinib_30min_R1 2 IGPALSCGNTVVVKPAEQTPLTALHVASLIK 31 1 P00352;Q5SYQ9;Q5SYQ8 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 94.721 4.6988e-08 22130000.0 3841.5 3479.2 4012.7 3987.7 4215.6 3453.1 3644.8 3597.1000000000004 1790.3000000000002 2951.2 False True 3930.999475742201 3071.853646563801 3467.7973801833455 3291.3230533998044 3834.2997243246277 3418.3649491639426 3369.869801554685 3501.693222972495 3038.0083416615016 3330.015267122343 1.1804749108970911 0.922474343253797 1.0413758202316195 0.9883807698707715 1.1514360796423813 1.0265313144098427 1.0119682737871598 1.05155470533278 0.912310634625654 1.0 11.701313076298325 -8.246038136321996 23.927462390810756 0.9561553166229478 1.0421585138941083 0.19546412759011822 0.07306068421689041 648.2623469614756 1007150.5281032393 0.04725196146976942 0.017693684311999126 5.674947702979415e-09 8.246038136321996 0.08600319727116046 IGPLGLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 IGPLGLSPK 9 0 P30050 P30050 RPL12 60S ribosomal protein L12 1 IGPLGLS(1)PK 88.155 0.031569 204560000.0 5648.7 6143.1 7371.5 7389.1 5342.7 5988.9 5446.0 5368.9 3920.6 5267.1 True False 5780.303719543141 5423.8629961502875 6370.490788751095 6098.73239558555 4859.453728330299 5928.657103486124 5035.203835400247 5226.499331354987 6652.971850705508 5943.183590898651 0.9725938347916858 0.9126191229320851 1.071898704005513 1.0261726400182396 0.8176516262718236 0.9975557734015195 0.8472233371876854 0.8794107150515778 1.119428964115095 1.0 12.537020232594996 -4.37938481390094 19.938677137857784 0.9570884842291268 12.248172507549787 0.0 0.09344077614741382 4244.598592172365 594538.6871259429 0.02242924714012049 17673.581254727465 4.1746030502467085e-05 4.37938481390094 11.29108402332066 IGPLGLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 IGPLGLSPK 9 0 P30050 P30050 RPL12 60S ribosomal protein L12 1 IGPLGLS(1)PK;IGPLGLS(1)PK 108.9 0.01174 159637000.0 539190.0 503830.0 469810.0 480990.0 394590.0 344220.0 470570.0 440480.0 268440.0 371550.0 True False 509223.9783485863 542472.1409312127 439582.9360904514 415478.3322459698 345018.07652064296 391633.1804819528 492452.43741676566 441761.7238746101 322135.5008402811 360822.38609716506 1.4112870984990895 1.5034326079345077 1.2182806639166703 1.151476039887632 0.9561991988704764 1.0853904734627269 1.3648056672519044 1.2243190580632353 0.8927813607261439 1.0 18.460929323311376 -5.434933168635754 2.8681184004260873 1.1115740729865264 1.459607007478436 0.542256308510814 0.13021503507999713 0.22037355230281344 3.476677516122761 0.037960807138544946 0.09114160073503526 3.673388240482402e-06 5.434933168635754 0.34803293449190953 IGQQVDREPGDVAT(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 IGQQVDREPGDVATPPR 17 1 H3BT22;Q9Y5N6 H3BT22 ORC6 Origin recognition complex subunit 6 1 IGQQVDREPGDVAT(1)PPR;IGQQVDREPGDVAT(1)PPR;IGQQVDREPGDVAT(1)PPR;IGQQVDREPGDVAT(1)PPR 162.26 0.00017485 175589200.0 9187.1 9268.1 12128.900000000001 12412.3 10858.0 8512.75 10261.5 9426.41 5002.57 8045.800000000001 True False 9401.141555015274 8182.986543377209 10481.86199927873 10244.72481272774 9875.895817135595 8427.119463958574 9487.466793418955 9176.390985505031 8488.995916743324 9078.556802728706 1.0355326027358898 0.9013532350117236 1.1545735987605692 1.1284530168548952 1.0878266261623473 0.9282443946845899 1.0450412989173945 1.0107764025606933 0.9350600652949398 1.0 13.14824725849652 -6.744086862839702 24.987886349018897 0.9883239951905695 1.0615331753907307 0.2291472033222578 0.07103779699396999 433.57613267201015 624355.1706724433 0.0251441831259397 0.025088191309361362 1.8026571570015215e-07 6.744086862839702 0.0732091802001612 IGQQVDREPGDVAT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 IGQQVDREPGDVATPPR 17 1 H3BT22;Q9Y5N6 H3BT22 ORC6 Origin recognition complex subunit 6 1 IGQQVDREPGDVAT(1)PPR;IGQQVDREPGDVAT(1)PPR 112.67 0.0050686 71859200.0 42366.0 50539.2 49940.9 51665.9 55606.4 35979.0 40031.4 39601.3 36705.0 48356.1 True False 40011.467324535384 54415.394130859015 46727.75686554062 44628.91529135124 48620.626904476696 40934.78066515647 41892.93942071426 39716.53322665188 44047.02562338895 46959.93374876363 0.8520341518920651 1.1587621571610858 0.9950558515592216 0.9503615471460548 1.0353640438378342 0.8716958776849681 0.8920996278410896 0.8457536043201412 0.9379703527488181 1.0 15.519142752639715 -6.762723105971426 24.99886493278349 0.8987757188315189 1.0043840499065098 0.22216218972380974 0.08147399454989966 44.274426115817235 862174.6015502298 0.026729363023975366 0.024878201337473167 1.7269385888641017e-07 6.762723105971426 0.1056083310749909 IGRPMVAS(ph)PNQR ddPTM_A459_Selumetinib_30min_R1 1 IGRPMVASPNQR 12 1 Q8IWZ3-6;H7C0V5 Q8IWZ3-6 ANKHD1;ANKHD1-EIF4EBP3 Ankyrin repeat and KH domain-containing protein 1 1 IGRPMVAS(1)PNQR 132.86 0.0086557 11175000.0 1524.5 1970.9 2095.6 2351.0 2123.5 1618.7 1829.1 1835.7 902.49 1769.5 True False 1560.0178838393817 1740.1461117534473 1811.0290303068293 1940.4419837357236 1931.4297999343753 1602.417347662006 1691.129514383142 1787.0112728060408 1531.4596147383609 1996.632561389601 0.781324473018537 0.8715404854172837 0.9070417188059896 0.9718573268109129 0.9673436351204017 0.8025599595284412 0.8469908520404789 0.8950125863730933 0.767021255865179 1.0 10.9633531439161 -6.770693031821812 24.998421630902037 0.8547973553126985 0.9026534741346484 0.05229406523193514 0.07607720296889868 544.981990944419 1472240.161783551 0.026814568305978087 0.023970503336094972 1.695535816227444e-07 6.770693031821812 0.047856118821949845 IGRPMVAS(ph)PNQR ddPTM_A459_Selumetinib_30min_R2 1 IGRPMVASPNQR 12 1 Q8IWZ3-6;H7C0V5 Q8IWZ3-6 ANKHD1;ANKHD1-EIF4EBP3 Ankyrin repeat and KH domain-containing protein 1 1 IGRPMVAS(1)PNQR 81.128 0.021353 9640400.0 14522.0 13066.0 21231.0 17370.0 15737.0 14791.0 12438.0 13818.0 9772.7 17787.0 True False 13714.925376171997 14068.12018618822 19865.02057456499 15004.176035078677 13759.977369434984 16828.325990670375 13016.391645429432 13858.20809230695 11727.513072052672 17273.443093823913 0.7939890907491248 0.8144363639475126 1.1500324785663427 0.8686268252125943 0.7965972559550005 0.974231130369562 0.7535493401476755 0.802284062131303 0.6789331465853395 1.0 14.076268061680091 -7.273068048713853 24.515755728211975 0.7922153083967624 0.9010651089072329 0.10741905775145821 0.1248508623166247 1192.3669782265622 2513756.391747738 0.05195635165737924 0.03538361848469793 5.3325133488063013e-08 7.273068048713853 0.10884980051047055 IGS(ph)MTGAEQALLPR ddPTM_A459_Selumetinib_30min_R2 2 IGSMTGAEQALLPR 14 0 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 IGS(0.999)MT(0.001)GAEQALLPR;IGS(0.994)MT(0.006)GAEQALLPR 109.55 0.0045316 1485400.0 7860.0 5827.129999999999 7005.0 7524.8 7587.099999999999 3395.48 9224.7 6546.0 5326.4 6159.5 True False 7423.172666072981 6274.052133823894 6554.3059264673275 6499.909258995974 6633.940668465412 3863.176548901455 9653.666828396277 6565.047776251359 6391.828832050645 5981.659230697054 1.2409888928440251 1.048881571458688 1.0957337544124093 1.0866398449512689 1.1090469069887732 0.645836949232441 1.6138777646936127 1.0975295520949162 1.0685712083444434 1.0 12.546330008528427 -10.09169675835043 14.268184529122681 0.9999173054369933 1.109378402320405 0.022242588513506134 0.2220091058027169 0.0 0.0 0.20900549580582903 0.050691278561295426 8.096610393364995e-11 10.09169675835043 0.10946109688341166 IGSS(ph)LSYVNTTEEK ddPTM_A459_Selumetinib_30min_R1 1 IGSSLSYVNTTEEK 14 0 K7EQL6;Q8NFA0;K7EL53;K7EKZ1 K7EQL6 USP32 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 32 1 IGS(0.26)S(0.738)LS(0.001)YVNTTEEK 91.969 0.024701 0.0 1352.2 1648.2 1424.1 1720.9 1796.9 1214.2 1365.1 1347.8 1035.3 1114.9 True False 1383.7036290768197 1455.2279777726083 1230.7150420213572 1420.3771202938344 1634.3707122684611 1201.9862504053929 1262.1294079516847 1312.0519657285956 1756.8284846797476 1258.008275045643 1.0999161583628028 1.1567713874694583 0.9783044089886488 1.1290681853760465 1.2991732603739534 0.9554676819290259 1.00327591875808 1.042959725905612 1.396515841373147 1.0 10.296925696806195 IGTLHT(ph)SPDLK ddPTM_A459_Selumetinib_30min_R2 1 IGTLHTSPDLK 11 0 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 IGT(0.001)LHT(0.499)S(0.499)PDLK 168.85 0.0010653 4301200.0 45174.0 36192.0 45878.0 47674.0 43423.0 35188.0 42419.0 41917.0 40276.0 40463.0 True False 42663.40992585 38967.81002437808 42926.25942818959 41180.71895776283 37967.81453345465 40034.827595139584 44391.56755165387 42038.97153026708 48332.32540546555 39294.728054500316 1.0857285961281484 0.991680359012313 1.0924177759584561 1.0479960288985004 0.9662317672944502 1.0188345759668518 1.129707972277717 1.0698374466915919 1.22999516216095 1.0 15.262048146999767 -7.260065411144408 24.977295696991327 1.1132049343961097 1.0321360549447252 0.23615961403948904 0.06443831009593591 164.00558745672427 2981486.1297020046 0.024568169033012774 0.017944226464966576 5.494581111422644e-08 7.260065411144408 -0.08106887945138452 IGTLHTS(ph)PDLK ddPTM_A459_Selumetinib_30min_R1 1 IGTLHTSPDLK 11 0 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 IGTLHT(0.006)S(0.994)PDLK 74.133 0.03688 15428000.0 4977.8 4500.5 5640.3 5519.8 4655.9 4970.8 4894.2 4998.1 2747.7 4301.1 True False 5093.7730548872905 3973.579367774314 4874.378239950187 4555.870549478706 4234.774667065906 4920.798265125288 4525.026553656976 4865.5341518831365 4662.646215932135 4853.188081261828 1.049572563353636 0.8187565165908806 1.0043662347993836 0.9387376860725704 0.87257584007848 1.0139310866859874 0.9323822769465941 1.0025439093673243 0.9607388252548102 1.0 12.244717056292284 -6.785103847884283 24.999895110332925 0.978982137255947 0.9341047761750554 0.11103935900332995 0.0633282671861348 535.1648438900235 565360.830858359 0.02094047506676432 0.018478439468960613 1.6401975245845657e-07 6.785103847884283 -0.044877361080891576 IGTLHTS(ph)PDLK ddPTM_A459_Selumetinib_30min_R2 1 IGTLHTSPDLK 11 0 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 IGTLHT(0.161)S(0.839)PDLK 131.83 0.0034827 0.0 46121.0 41818.0 43436.0 48607.0 48576.0 37409.0 49561.0 47619.0 32946.0 42261.0 True False 43557.77945699136 45025.30613393689 40641.375049541006 41986.642748248065 42473.44860505014 42561.75018490896 51865.684703258405 47757.56340625019 39536.12058815346 41040.815122735316 1.0613283222257865 1.0970860593115825 0.9902672480553869 1.0230460243707193 1.0349075299316164 1.0370590851479238 1.2637586399819445 1.163660206636442 0.9633366313490128 1.0 15.324771764535589 IHAENAIR ddPTM_A459_Selumetinib_30min_R2 2 IHAENAIR 8 0 Q7LBR1 Q7LBR1 CHMP1B Charged multivesicular body protein 1b 0 ; 99.442 0.026201 3184300.0 9938.5 10008.0 11410.400000000001 15142.5 13063.1 9016.7 9603.5 9045.5 7702.0 13381.5 False True 9386.157956967736 10775.581419208009 10676.267286704186 13080.065377730507 11421.996592404283 10258.66857954686 10050.081778974243 9071.820907436868 9242.61521186055 12995.141325687564 0.7222820992653668 0.8292007873671878 0.8215583824086893 1.0065350618292295 0.8789436225542513 0.7894233946704755 0.7733722571456914 0.698093285796327 0.7112362213091614 1.0 13.665684703144859 -6.871374747222091 5.17990349707877 0.7721137427158818 0.8571118077952956 0.052739912718627324 0.1020830654577403 0.45608767382721754 18.966758389026865 0.036809561817381056 0.03249564873212205 1.3446995290610203e-07 6.871374747222091 0.08499806507941376 IHAESLLLDS(ph)PAVAK ddPTM_A459_Selumetinib_30min_R2 2 IHAESLLLDSPAVAK 15 0 Q9H4L5;Q9H4L5-5;Q9H4L5-2;Q9H4L5-6 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 IHAESLLLDS(1)PAVAK;IHAESLLLDS(1)PAVAK 139.67 0.00025152 1680100.0 29176.0 23401.2 26495.0 33370.0 32632.0 31169.0 30459.0 29239.0 26983.0 30953.0 True False 27554.514720781874 25195.996793282397 24790.34054557484 28824.948433539183 28532.476426218636 35462.246825989096 31875.403853363503 29324.08064922298 32380.35396801264 30059.30646444775 0.9166716721615522 0.8382095183427679 0.8247143218322516 0.9589359111671959 0.9492060789880514 1.179742681952147 1.060417142060936 0.9755408257308149 1.077215603969775 1.0 14.87552410298056 -6.2262327773364685 1.999809781583997 1.0544835871690494 0.8620592076830269 0.6321971517143437 0.06238602751804663 0.21071211497000597 1.6554705070755136 0.021511226028402254 0.02873934733391903 5.939737095346975e-07 6.2262327773364685 -0.19242437948602253 IHDENLR ddPTM_A459_Selumetinib_30min_R1 2 IHDENLR 7 0 O95232;J3KPP4;D6RDI2 O95232 LUC7L3 Luc7-like protein 3 0 ; 162.31 0.00069791 7462800.0 778.8199999999999 1298.49 903.21 1064.88 1171.5 889.22 1047.3600000000001 797.37 684.2 912.8399999999999 False True 796.9649906800839 1146.4621871483757 780.5590429773968 878.918698273286 1065.538031845124 880.2752541471607 968.3567919656267 776.221157377215 1161.03742800916 1030.0119058145708 0.7737434744017013 1.1130572187335173 0.7578155539475073 0.8533092610984969 1.034490985812885 0.8546262904126405 0.940141358074706 0.7536040632106589 1.1272077744489464 1.0 10.008445298148608 -8.278127984494413 24.95970747247149 1.0636038953000964 0.8931935042954559 0.27390691370461107 0.11565420762669322 1215.8524219653862 1818427.2114127462 0.10354909572165892 0.02704009176987325 5.2707451221063765e-09 8.278127984494413 -0.1704103910046405 IHDENLR ddPTM_A459_Selumetinib_30min_R2 2 IHDENLR 7 0 O95232;J3KPP4;D6RDI2 O95232 LUC7L3 Luc7-like protein 3 0 ; 193.98 3.6158e-06 9900600.0 11049.5 12866.5 13320.2 15513.900000000001 14817.6 12299.4 9832.0 12805.7 11417.5 8523.0 False True 10435.413024653113 13853.319177681826 12463.192833937192 13400.880057029759 12956.080616975265 13993.530707163223 10289.207481738398 12842.962466902241 13701.319031604497 8276.918844586568 1.260784746183453 1.6737290092849522 1.50577685585121 1.619066262295717 1.5653265255160806 1.6906690726242346 1.2431204986947464 1.5516598275337745 1.6553646699780924 1.0 13.01487809647983 -11.07789400952418 4.259959554009593 0.9932129733340456 1.5337011898728015 0.5258743580611271 0.15078424011842337 0.009423651800921638 0.0009843699889783356 0.14155217590035246 0.03405206652041771 8.3580697378082e-12 11.07789400952418 0.5404882165387559 IHDPQLLTER ddPTM_A459_Selumetinib_30min_R1 1 IHDPQLLTER 10 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 89.9 0.042421 3135900.0 1100.6 1524.0 1504.8 1565.3 1579.2 1378.0 1197.7 1297.1 868.37 1085.4 False True 1126.241838605197 1345.569371511621 1300.4564252747264 1291.9497393200877 1436.3616388304054 1364.138571123893 1107.3565247261981 1262.6966944254052 1473.5604667645632 1224.7216626913091 0.9195900365886368 1.0986736109123365 1.061838346532543 1.0548925349136438 1.1728065915597674 1.1138355862230909 0.904169950168757 1.0310070711500656 1.2031798829510651 1.0 10.258238195945903 -4.754872259306357 24.858663574823158 1.0706175274352672 0.9195897622440127 0.2405788862181345 0.0807807545133748 324.6761344474487 1228882.5268655692 0.02061258330335225 0.19164492697092672 1.7584407547917516e-05 4.754872259306357 -0.1510277651912545 IHEGCEEPATHNALAK ddPTM_A459_Selumetinib_30min_R1 1 IHEGCEEPATHNALAK 16 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 85.287 0.0092632 4135100.0 3538.5 4574.9 3876.5 4093.3 3767.4 3692.5 3499.6 3105.6 2217.6 3149.6 False True 3620.9401652775687 4039.2685811866886 3350.0925920902964 3378.4819957573104 3426.639335188492 3655.356802521751 3235.6223544558775 3023.2293995894993 3763.1052329042836 3553.8818397019973 1.018869036338359 1.13657931337565 0.9426572810229422 0.9506455611480333 0.9641961915863317 1.0285532742496195 0.9104473644310002 0.8506837131768583 1.0588717922090034 1.0 11.795179999762547 -5.274740843123995 24.88698752072566 0.9579532687617007 1.0777241758153913 0.35334760025218315 0.06160731152418913 650.1837943345204 1216491.643867623 0.01582659650714405 0.03324366329551223 5.3120133384805455e-06 5.274740843123995 0.11977090705369053 IHEKDPNSATATAPPS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 IHEKDPNSATATAPPSPLK 19 1 Q92766;Q92766-2;Q92766-5;Q92766-3;C9JU34;Q92766-6;C9JPJ6 Q92766 RREB1 Ras-responsive element-binding protein 1 1 IHEKDPNS(0.001)AT(0.003)AT(0.022)APPS(0.973)PLK;IHEKDPNSATAT(0.003)APPS(0.997)PLK 59.918 0.017587000000000002 12915000.0 114669.0 100449.0 103054.0 83461.0 81176.0 62589.0 85350.0 97693.0 79734.0 95389.0 True False 108296.15603637711 108153.11530555776 96423.6178367115 72093.46782174449 70977.94515735237 71210.06662362714 89318.94411781656 97977.2704560532 95683.02795410132 92634.87171961355 1.1690646732276697 1.1675205384092795 1.0408997826279254 0.7782540903166184 0.7662119441605945 0.7687177118263321 0.9642043267266174 1.0576715726730854 1.0329050624014884 1.0 16.49926776727351 -5.516113300491834 4.565841698893523 0.9020863220050926 1.1587259125193252 0.5011566362605118 0.10352581349716 0.17457592026324253 9.395944783527558 0.03254903616185726 0.06429506220161962 3.0470999462313747e-06 5.516113300491834 0.2566395905142326 IHFPLATYAPVISAEK ddPTM_A459_Selumetinib_30min_R1 2 IHFPLATYAPVISAEK 16 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 154.69 0.0001496 49757000.0 22826.0 27800.0 27662.0 29934.0 27498.0 23797.0 25084.0 23975.0 14552.1 20261.4 False True 23357.80138833569 24545.163076130626 23905.652336489573 24706.588830772056 25010.8107551662 23557.62378594724 23191.893684755738 23339.105118224576 24693.850856667785 22862.14805274895 1.0216800859850588 1.073615787086083 1.0456433175628548 1.0806766176899694 1.093983412996002 1.030420401949705 1.0144232130439352 1.0208623032435604 1.0801194533292593 1.0 14.480673340383497 -6.87281043272337 12.262890554094005 1.0294321983567098 1.0636989136201127 0.28780548144830076 0.026701310726235175 0.6099151883576455 63.870705742279945 0.00936636562024482 0.00826105485845614 1.3402615769552954e-07 6.87281043272337 0.03426671526340286 IHFS(ph)PSEPK ddPTM_A459_Selumetinib_30min_R2 2 IHFSPSEPK 9 0 Q8IZT6-2;Q8IZT6 Q8IZT6-2 ASPM Abnormal spindle-like microcephaly-associated protein 1 IHFS(0.982)PS(0.018)EPK;IHFS(0.973)PS(0.027)EPK 110.39 0.007197700000000001 6062100.0 93087.0 78021.0 84451.0 104632.0 92704.0 80956.0 95990.0 85740.0 70526.0 86543.0 True False 87913.59719678572 84004.95982294445 79017.51460329643 90380.94109973262 81057.6947357248 92106.95415460154 100453.72520057655 85989.48920497883 84633.17066108495 84044.27872428209 1.046039046693439 0.9995321644502818 0.9401890979696952 1.0753967131568676 0.9644641606318598 1.0959336620255862 1.1952476328594326 1.0231450672219848 1.007006924751354 1.0 16.358861991550512 -6.771083182672459 24.990468424931734 1.0738995392821682 1.0051100824994765 0.17067554279382324 0.06343183806036806 330.9893657826982 857703.5980464758 0.022864290658181994 0.020411429151256412 1.6940133062260493e-07 6.771083182672459 -0.06878945678269166 IHGVGFK ddPTM_A459_Selumetinib_30min_R1 1 IHGVGFK 7 0 P62899-3;H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899;P62899-2;B8ZZK4 P62899-3 RPL31 60S ribosomal protein L31 0 103.71 0.029497 0.0 6605.1 7531.5 8434.4 8928.9 8543.7 7109.1 7228.8 7949.9 4682.4 7395.9 False True 6758.985978712697 6649.7084787006415 7289.054806842872 7369.6352312113495 7770.923843512748 7037.588908546346 6683.525796059733 7739.042827085436 7945.69081103491 8345.235807166626 0.8099215090972376 0.7968269120676112 0.8734390465735266 0.8830949060639531 0.9311808585252107 0.8433061774602805 0.8008792022773199 0.9273605930271485 0.9521229830571596 1.0 13.026737100340249 -14.522877992596358 0.03028964597955069 1.8448471225194585 0.30896069019851324 0.5813852474018171 0.0428780308227032 1172.7106585919375 2.6636821497101235 105.90970847929056 42.42535498014589 3.000005199361237e-15 14.522877992596358 -1.5358864323209453 IHGVGFK ddPTM_A459_Selumetinib_30min_R2 2 IHGVGFK 7 0 P62899-3;H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899;P62899-2;B8ZZK4 P62899-3 RPL31 60S ribosomal protein L31 0 ; 103.71 0.025934 13229100.0 203174.0 174878.0 203826.0 214417.0 212927.0 165685.0 179884.0 181092.0 158169.0 193331.0 False True 191882.40244996327 188290.58027860237 190712.05706896883 185213.03471004366 186177.20666846796 188506.60481131906 188248.9624333839 181618.9477386056 189807.21961111014 187749.0316957367 1.0220154038446656 1.0028844281005045 1.0157818410378487 0.9864926228232014 0.9916280525493415 1.0040350307468433 1.002662760671157 0.9673495841668819 1.0109624422388974 1.0 17.518445941583224 -5.753465062769093 24.99576463905683 0.9939611209068068 1.0124929486756542 0.334499534716981 0.012107554561622746 208.05534540907547 652150.0917422568 0.0032110043895394952 0.005427210227907372 1.7641476772988644e-06 5.753465062769093 0.01853182776884743 IHLDEK ddPTM_A459_Selumetinib_30min_R2 4 IHLDEK 6 0 P37837 P37837 TALDO1 Transaldolase 0 ;;; 127.66 0.019185 32085100.0 461714.0 378149.0 366342.0 414371.0 424506.0 304955.0 403966.0 473004.0 357758.0 456384.0 False True 436053.78426758514 407151.8123593211 342771.95456301037 357932.9549701539 371175.76114820904 346959.7831441338 422751.21944344294 474380.36332997214 429319.59659371787 443207.0080919626 0.9838603097564441 0.9186493104252533 0.7733901953370904 0.8075976878413554 0.8374771932107907 0.782839117634489 0.9538459720287744 1.0703358806807073 0.9686660832417091 1.0 18.757621168232724 -7.474379286443689 5.41641502077765 1.0148451036977948 0.848346872935035 0.5747555287016868 0.0636527729435331 0.15079449887759344 10.380754146186156 0.029835080623479778 0.019264071416570442 3.3544452938607536e-08 7.474379286443689 -0.16649823076275982 IHLGS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 IHLGSSPK 8 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 IHLGS(0.627)S(0.373)PK 94.309 0.015109 49172000.0 8058.6 9370.8 10747.0 11486.0 8378.0 8532.1 8822.5 8353.3 3975.5 7016.5 True False 8246.349700694027 8273.662379633273 9287.616429045383 9480.185718923232 7620.211379256039 8446.274820526976 8157.011721964502 8131.743348657566 6746.133140968159 7917.136121497676 1.0415824073432849 1.045032225373454 1.1731030370725084 1.197426136602774 0.9624959407435997 1.0668346092462035 1.0302982791738902 1.0271066739116888 0.8520926048814732 1.0 12.950762940913084 -7.4614968170747025 0.9337358401316099 0.9418387434769782 1.097424505153035 0.3785497629231447 0.07328509932996717 0.6443550893674855 1.0481432679134894 0.062400869336210314 0.030990364182807057 3.455438620444476e-08 7.4614968170747025 0.15558576167605676 IHLGSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 IHLGSSPK 8 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 IHLGS(0.202)S(0.798)PK 106.2 0.0091479 57354000.0 5556.3 6806.9 7657.3 8086.8 6069.7 6951.7 6423.5 6023.0 3276.5 5065.7 True False 5685.750979322243 6009.944983558042 6617.4807185381205 6674.5921880365995 5520.6967066925745 6881.772209638581 5938.970223410482 5863.2504745387505 5559.981193908233 5715.931939096525 0.9947198531935193 1.0514374641955568 1.1577255973387424 1.1677172260192452 0.9658436744026715 1.2039632876955377 1.0390204583767684 1.0257733186839715 0.9727164796834614 1.0 12.480773022699646 -7.679490460265235 2.9729012644743937 0.9953686191120077 1.0908918468396098 0.24066335810748496 0.07178580495435952 0.3806560432707539 6.729530029234656 0.04087311273536102 0.02028423008854785 2.0917488540603474e-08 7.679490460265235 0.09552322772760213 IHLGSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 IHLGSSPK 8 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 IHLGS(0.038)S(0.962)PK;IHLGS(0.265)S(0.735)PK;IHLGS(0.171)S(0.829)PK 131.52 0.002347 125174000.0 926360.0 869920.0 875030.0 915830.0 841960.0 603068.0 769585.0 752633.0 599456.0 809140.0 True False 874876.619712897 936640.0667663313 818731.5224606281 791092.3741051279 736185.4575820991 686135.1428937594 805372.2274037466 754823.0374248986 719363.9502000881 785778.0258018023 1.1133890118907044 1.1919906589530682 1.0419374118093978 1.0067631673689308 0.9368873058404767 0.8731920725240847 1.02493605186013 0.9606059378597188 0.9154798512799518 1.0 19.583762297985466 -5.601955660789207 1.9260555189525261 0.9517540104106748 1.1542165647233888 0.7362237222804979 0.046074034780034384 0.16630278101376322 1.2289996393513924 0.013736193126112392 0.033041887463070914 2.500600647002016e-06 5.601955660789207 0.2024625543127141 IHLPALS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 IHLPALSPR 9 0 Q8NEA6-2;F8WEV9;Q1PHJ8 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 IHLPALS(1)PR;IHLPALS(1)PR 103.43 0.010084 17728500.0 7564.9 9560.5 9939.2 10243.099999999999 8833.9 7815.6 8509.1 7351.1 4549.2 6860.6 True False 7741.147451267004 8441.15221544413 8589.511232117606 8454.334871800667 8034.875304751716 7736.9821599970255 7867.251736284283 7156.124948261966 7719.660139578003 7741.2248379030725 0.9999900033085605 1.0904155856724416 1.109580384496921 1.0921185017655113 1.037933333935846 0.9994519371294742 1.0162799687414 0.9244176597511671 0.9972143040957183 1.0 12.918346136272875 -6.734465946833225 1.7679990271801576 0.9786315918997691 1.0766845799786031 0.562614617358961 0.0355798435178026 0.2501988590779534 1.6167215697444672 0.015022663436900346 0.014000662683160902 1.843036996414986e-07 6.734465946833225 0.098052988078834 IHLPALS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 IHLPALSPR 9 0 Q8NEA6-2;F8WEV9;Q1PHJ8 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 IHLPALS(1)PR;IHLPALS(1)PR;IHLPALS(1)PR 86.11399999999998 0.022672 4195300.0 44145.0 39046.6 47147.0 45667.1 52025.0 38096.7 39378.0 41657.0 38509.9 48661.0 True False 41691.59762643662 42041.34866539243 44113.6133497723 39447.16219985843 45489.154390598946 43344.17461758987 41209.15502602673 41778.21497331239 46212.95605650851 47256.03049353833 0.8822492535029454 0.8896504472829357 0.933502304130354 0.8347540364240356 0.962610568757336 0.9172199646247614 0.8720401310825624 0.8840821909285215 0.9779271676834463 1.0 15.528210827570364 -8.354355478120905 4.396329873733501 0.9973919134680287 0.897976161346868 0.551717568875871 0.033311374601464584 0.16633999729138893 5.272931645457068 0.031209309611387893 0.008248399541076746 4.422262537585593e-09 8.354355478120905 -0.09941575212116072 IHNVGS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 IHNVGSPLK 9 0 P52701-2;P52701;P52701-3;A0A087WWJ1;A0A494C0M1;P52701-4 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 IHNVGS(1)PLK 86.288 0.02252 20918000.0 6977.5 8339.6 7773.9 8927.4 6691.4 7102.7 7272.4 7932.4 4487.7 6831.5 True False 7140.062174148439 7363.1957550251445 6718.247078976077 7368.397178052863 6086.164051462619 7031.253286735616 6723.83701295717 7722.006983933451 7615.299131360283 7708.389569445068 0.92627157849554 0.9552184264547005 0.8715500194238014 0.9558932007354836 0.7895506573237145 0.9121559339199043 0.8722751947578622 1.0017665706131875 0.9879234907309586 1.0 12.912213769594139 -7.768402327032381 24.99792523470484 0.9961338099639302 0.8974274319369357 0.4966507345529467 0.045673540400391975 140.90504138621054 505858.1463196935 0.024282044248844985 0.01206654826404082 1.7045026193949945e-08 7.768402327032381 -0.09870637802699445 IHNVGS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 IHNVGSPLK 9 0 P52701-2;P52701;P52701-3;A0A087WWJ1;A0A494C0M1;P52701-4 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 IHNVGS(1)PLK 84.821 0.023806 24820000.0 171690.0 161010.0 180260.0 170120.0 175190.0 149060.0 164320.0 183730.0 132220.0 160070.0 True False 162148.15712952573 173358.94927125136 168662.26785224836 146949.36252663084 153181.06598152858 169591.66196804328 171961.20559390282 184264.623881861 158667.69453547194 155448.36318819335 1.043099803715664 1.115218878576255 1.085005106474216 0.9453258915870782 0.9854144671570464 1.0909839028843769 1.1062271873890253 1.185375131025222 1.020709972631755 1.0 17.246075900168805 -6.902413173920613 12.509119471373786 1.0942489694473954 1.0371098648800943 0.09264415696953954 0.06501228880052362 1.0973108452044125 133.6141517859662 0.023990796880456838 0.02115925410848488 1.2519495433197664e-07 6.902413173920613 -0.05713910456730109 IHPMAYQLQLQAAS(ph)NFKSPVK ddPTM_A459_Selumetinib_30min_R1 2 IHPMAYQLQLQAASNFKSPVK 21 1 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 IHPMAYQLQLQAAS(0.571)NFKS(0.429)PVK;IHPMAYQLQLQAAS(0.5)NFKS(0.5)PVK 60.528 0.0084899 118713000.0 6546.1 7093.3 8867.7 9194.0 7272.1 7071.299999999999 5711.1 6610.8 4240.4 5511.0 True False 6698.611393506708 6262.813138414294 7663.515046789402 7588.440492754674 6614.339838993532 7000.1691422266895 5280.307128967011 6435.4601090952665 7195.649093437652 6218.390531685838 1.0772259090795122 1.0071437466820556 1.2323952649387209 1.2203222769762916 1.0636739209752317 1.1257204105398808 0.8491436975630882 1.034907678490656 1.1571561896558584 1.0 12.602325509323375 IHPMAYQLQLQAAS(ph)NFKSPVK ddPTM_A459_Selumetinib_30min_R2 2 IHPMAYQLQLQAASNFKSPVK 21 1 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 IHPMAYQLQLQAAS(0.5)NFKS(0.5)PVK;IHPMAYQLQLQAAS(0.5)NFKS(0.5)PVK 87.38799999999998 0.00041086 38017000.0 324395.0 269414.0 261667.0 295180.0 295395.0 236581.0 256619.0 255380.0 203295.0 324361.0 True False 306366.4245560746 290077.18749745295 244831.63010148818 254975.9747860976 258284.8392351943 269167.8852815082 268552.2919809019 256123.11351956503 243959.6805368981 314995.85513891093 0.9726046218004017 0.9208920776736284 0.7772534974897342 0.8094581900884219 0.8199626598937072 0.8545124670380411 0.8525581768765569 0.8130999482727053 0.7744853672100339 1.0 18.264973319525936 -5.065624219314516 4.807501673686655 0.8307549781594118 0.9626899556356528 0.3498519412305131 0.06065485042749905 0.18216440660009028 8.176222030584976 0.01450624692272648 0.0441896394356005 8.597571192209771e-06 5.065624219314516 0.13193497747624106 IHPMAYQLQLQAASNFKS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 IHPMAYQLQLQAASNFKSPVK 21 1 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 IHPMAYQLQLQAAS(0.262)NFKS(0.738)PVK;IHPMAYQLQLQAAS(0.103)NFKS(0.897)PVK 66.467 0.0039708 273540000.0 6212.700000000001 6184.3 9448.2 9777.1 7730.7 7228.8 5940.200000000001 6556.1 4406.799999999999 5444.2 True False 6357.443822190181 5460.239280996933 8165.186335247655 8069.713023897288 7031.459549965937 7156.084835225253 5492.125931517541 6382.210930785908 7478.017740062501 6143.016100998734 1.0349059350758636 0.88885316125237 1.3291819850382869 1.3136402202470723 1.1446265864129446 1.1649138985752965 0.8940438770174522 1.0389376856343069 1.2173202246444905 1.0 12.584731449308636 IHPMAYQLQLQAASNFKS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 IHPMAYQLQLQAASNFKSPVK 21 1 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 IHPMAYQLQLQAAS(0.139)NFKS(0.861)PVK;IHPMAYQLQLQAAS(0.078)NFKS(0.922)PVK 67.418 0.0046919 8422200.0 24776.0 21309.0 26031.0 18193.9 24614.0 21260.3 23836.0 20581.7 17615.2 22560.0 True False 23399.049106186285 22943.33178076572 24356.193800409856 15715.859433771906 21521.769268048076 24188.713343212043 24944.421230137967 20641.589339516133 21138.732209811234 21908.634182080597 1.068028655356559 1.047227845884223 1.1117166683229918 0.717336338867995 0.9823418972256635 1.1040721727416654 1.138565782915869 0.9421668721092253 0.9648585135033622 1.0 14.419211926855288 IHQDSES(ph)GDELSSSSTEQIR ddPTM_A459_Selumetinib_30min_R1 3 IHQDSESGDELSSSSTEQIR 20 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 IHQDS(0.031)ES(0.965)GDELS(0.003)SSSTEQIR;IHQDSES(1)GDELSSSSTEQIR;IHQDSES(1)GDELSSSSTEQIR 316.88 2.106099999999999e-118 43889000.0 2414.4900000000002 2844.92 2822.05 3197.9500000000003 2788.184 2172.1899999999996 2673.79 2372.2599999999998 804.316 1441.4 True False 2470.742919220301 2511.8354438325737 2438.831110411047 2639.488065456254 2535.9932494938653 2150.339740790717 2472.1038676193207 2309.3399586135315 1364.8655070836235 1626.4177304249627 1.519131815277694 1.5443974797152897 1.4995108973472706 1.6228844632470827 1.559250862834139 1.322132500503951 1.5199685919394095 1.419893496863275 0.839185088523968 1.0 10.667482132611537 -8.189646855396369 4.615729465531751 0.9191787344560649 1.508532733677169 0.8886598848853653 0.08261365270659074 0.06287018873307762 2.4822587176437287 0.06401683626326152 0.02198711393798148 6.461794533785122e-09 8.189646855396369 0.5893539992211041 IHQDSES(ph)GDELSSSSTEQIR ddPTM_A459_Selumetinib_30min_R2 4 IHQDSESGDELSSSSTEQIR 20 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 IHQDS(0.001)ES(0.999)GDELSSSSTEQIR;IHQDS(0.024)ES(0.976)GDELSSSSTEQIR;IHQDSES(1)GDELSSSSTEQIR;IHQDS(0.003)ES(0.997)GDELSSSSTEQIR 205.57 1.1554e-16 120866500.0 187483.0 171953.0 214032.0 220476.0 220121.0 145579.0 154064.0 167269.0 130681.0 161623.0 True False 177063.4454139137 185141.2421839602 200261.41414042216 190446.78845768643 192467.43207329203 165631.18581541514 161228.28127202464 167755.72509712644 156820.85153221907 156956.52404301506 1.128105037324783 1.1795702237469332 1.2759037278726884 1.2133728726401531 1.2262467791434075 1.055267927378557 1.0272161813919813 1.068803773019029 0.9991356045145418 1.0 17.26000547155619 -6.81264114755683 5.296566681049174 1.031825634026454 1.207859947492614 0.8278155048566656 0.03986251536935461 0.08307383881509224 5.010408039954697 0.014810497133926135 0.013260300461616772 1.5394261246987126e-07 6.81264114755683 0.17603431346615994 IHRAS(ph)DPGLPAEEPK ddPTM_A459_Selumetinib_30min_R1 5 IHRASDPGLPAEEPK 15 1 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK 179.9 9.3234e-05 548109000.0 23266.899999999998 28165.100000000002 27062.899999999998 27207.2 22200.300000000003 23055.1 24080.3 24210.600000000002 14073.699999999999 20430.8 True False 23808.97350049361 24867.51699840026 23387.90682586883 22455.973262396656 20192.286784781307 22823.18662635592 22263.903583839256 23568.456240887917 23882.04099762131 23053.29219284468 1.0327797566320474 1.0786969943546145 1.0145148306899094 0.9740896473505236 0.8758960158865562 0.9900185377184356 0.965758096396729 1.022346658504729 1.0359492604285758 1.0 14.492685173203286 -5.529960291150142 3.806492429145257 0.9772981873843014 1.0551487153879127 0.33536902844497185 0.042050979513288636 0.25028775048620294 8.020281176951514 0.012494922056185095 0.025019666595471363 2.9514790769329775e-06 5.529960291150142 0.07785052800361125 IHRAS(ph)DPGLPAEEPK ddPTM_A459_Selumetinib_30min_R2 4 IHRASDPGLPAEEPK 15 1 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK;IHRAS(1)DPGLPAEEPK 152.68 0.0010553 563725000.0 849660.0 577705.0 684500.0 716800.0 664150.0 624330.0 669600.0 616364.0 441145.0 653800.0 True False 802439.2986584696 622013.1158856462 640460.0152272492 619170.6034510294 580713.5394236676 710325.790396541 700737.7267872294 618157.5171954472 529386.3266211661 634923.0952235939 1.2638369980475876 0.9796668613331804 1.0087206152135724 0.9751899215966982 0.9146202804595793 1.1187587847098135 1.1036576430417266 0.9735943169270879 0.8337802335489748 1.0 19.27622233111112 -4.759547167469883 24.997309498756646 0.9943283467486338 1.2638373378486012 0.5257215490914071 0.07798419879716796 42.77834849402343 564977.031440365 0.020424386642258242 0.12868824042200183 1.7396137533505723e-05 4.759547167469883 0.2695089910999674 IHRAS(ph)DPGLPAEEPKEK ddPTM_A459_Selumetinib_30min_R1 4 IHRASDPGLPAEEPKEK 17 2 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 IHRAS(1)DPGLPAEEPKEK;IHRAS(1)DPGLPAEEPKEK;IHRAS(1)DPGLPAEEPKEK;IHRAS(1)DPGLPAEEPKEK 86.539 0.0043527 93550500.0 11405.5 10130.5 36605.1 36494.3 18460.5 18509.5 13084.8 14154.900000000001 9757.0 8483.3 True False 11671.225958760304 8944.416350458325 31634.32847742153 30121.255587854776 16790.751034466 18323.31123528135 12097.80300136708 13779.466070404884 16556.916376915193 9572.214189339578 1.2192817385718722 0.9344145642310823 3.3048078377364534 3.1467385697867414 1.7541135940277632 1.9142186826207597 1.2638458314942649 1.4395275531705982 1.729685112495118 1.0 13.224636963866201 -6.994026161966948 2.2564972018511202 1.3973776174154453 2.1433078857833796 0.17973362208515264 0.7150623822664467 0.6194709115898817 6.337479232669374 0.3386449664952927 0.2678884699064363 1.0138503093971894e-07 6.994026161966948 0.7459302683679343 IHRAS(ph)DPGLPAEEPKEK ddPTM_A459_Selumetinib_30min_R2 3 IHRASDPGLPAEEPKEK 17 2 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 IHRAS(1)DPGLPAEEPKEK;IHRAS(1)DPGLPAEEPKEK;IHRAS(1)DPGLPAEEPKEK 68.48100000000001 0.014274 53658000.0 313860.0 464238.0 375256.0 470764.0 367431.0 216729.0 130131.0 107037.0 76741.0 406085.0 True False 296416.9176811279 499843.5618395559 351112.4375078404 406645.1310868026 321271.0329051834 246581.45248002192 136182.34934968478 107348.45994907079 92091.34432269403 394360.27091445954 0.7516399078278946 1.2674795072041543 0.890334203021176 1.0311513635586476 0.8146637899406203 0.6252695077732812 0.345324718014569 0.27220911401685205 0.23352084658312225 1.0 18.589154691868316 -6.784766613605654 1.8870996187857012 0.40429859166159493 0.9977320069139748 0.49041300801227217 0.23679712592456403 0.24423635763039742 1.793981919216307 0.09281549303509057 0.08360389962002765 1.641471650007868e-07 6.784766613605654 0.5934334152523799 IHS(ph)PIIR ddPTM_A459_Selumetinib_30min_R1 3 IHSPIIR 7 0 O60885 O60885 BRD4 Bromodomain-containing protein 4 1 IHS(1)PIIR;IHS(1)PIIR;IHS(1)PIIR 96.668 0.015212 33697000.0 2541.1 3068.73 3375.77 3233.29 3033.1499999999996 2706.0 2712.95 2753.33 1709.6799999999998 2296.83 True False 2600.3026858801286 2709.4416649861264 2917.358975777288 2668.656597870214 2758.802118046126 2678.7800968514166 2508.309997291423 2680.3027443237224 2901.2020899133295 2591.6505035187765 1.0033384834682009 1.0454502492938074 1.125676078551597 1.029713147759269 1.0644962020536342 1.0336193453609355 0.9678426909360659 1.0342068657346273 1.119441871492419 1.0 11.339655461666736 -6.849961520387659 6.530453385524175 1.0288427806339668 1.0558665884291627 0.05575395206991596 0.04614962632919204 0.6719071347128424 40.86873222944322 0.016886607545730344 0.014923627043180994 1.412662704640711e-07 6.849961520387659 0.027023807795195864 IHS(ph)PIIR ddPTM_A459_Selumetinib_30min_R2 6 IHSPIIR 7 0 O60885 O60885 BRD4 Bromodomain-containing protein 4 1 IHS(1)PIIR;IHS(1)PIIR;IHS(1)PIIR;IHS(1)PIIR;IHS(1)PIIR;IHS(1)PIIR 90.601 0.019471 113213500.0 53440.5 50239.399999999994 54352.700000000004 58621.1 56489.299999999996 36674.600000000006 42047.2 45360.6 32639.699999999997 48690.0 True False 50470.4909492714 54092.600434867934 50855.70645674529 50636.805052962045 49392.60911325052 41726.193251128374 44002.478114946185 45492.59183614843 39168.552029416365 47284.19318818725 1.0673861082582703 1.1439890751563377 1.0755329218443828 1.0709034380988942 1.044590290811814 0.8824554346324893 0.9305959380510077 0.9621099307984723 0.8283646053455688 1.0 15.529070359725623 -6.62175985475451 4.0540954514823255 0.9192400286724746 1.089312801142284 0.7432282688032693 0.04740508355793676 0.10937844901784312 3.340957478492543 0.015699706285669288 0.015700873256727445 2.3891319998873883e-07 6.62175985475451 0.17007277246980934 IHTDFEK ddPTM_A459_Selumetinib_30min_R1 1 IHTDFEK 7 0 J3KQ32;Q9NTK5;Q9NTK5-2 J3KQ32 OLA1 Obg-like ATPase 1 0 134.06 0.0042408 6644800.0 3955.0 4386.7 4854.2 5572.2 4693.4 4191.8 4875.4 4618.5 2516.9 4116.7 False True 4047.1438049096446 3873.1031246784974 4195.026302211973 4599.119873148529 4268.882798687069 4149.634297849878 4507.644652792939 4496.002376997712 4270.995472897184 4645.118545053726 0.8712681421702737 0.8338007065078467 0.9031042505210065 0.9900974170068969 0.9190040592683507 0.8933322707702571 0.9704046536321074 0.9678983073069691 0.9194588752627378 1.0 12.181499699823043 -1.5228787452803385 0.270251987925086 0.9714449916420049 0.05765121609128325 0.5009239105670398 0.03635601059560425 44.82907429630746 0.6261992311136451 0.04428922529760039 19.112404408375415 0.029999999999999933 1.5228787452803385 -0.9137937755507217 IHTDFEK ddPTM_A459_Selumetinib_30min_R2 3 IHTDFEK 7 0 J3KQ32;Q9NTK5;Q9NTK5-2 J3KQ32 OLA1 Obg-like ATPase 1 0 ;; 124.59 0.0090058 12209900.0 150673.0 135200.0 167225.0 164796.0 169481.0 124982.0 134872.0 136570.0 116053.0 149411.0 False True 142299.1978518084 145569.4052634812 156465.92556081386 142350.50051104356 148189.28160063605 142197.13602636507 141143.81524379776 136967.39608961952 139266.84279174922 145097.11621360146 0.9807169264641058 1.0032549857792106 1.0783531033826754 0.9810705010944909 1.02131100512351 0.9800135229223491 0.9727541037825732 0.9439704913775546 0.9598181302702851 1.0 17.146659320749258 -6.936675750843687 2.2808535357121342 0.9641602962103634 1.0148432477369143 0.33581938830775704 0.02893997669969366 0.32835275402155595 3.463485003390678 0.01205617108625797 0.009928494272032615 1.1569757309309335e-07 6.936675750843687 0.05068295152655089 IIAPS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 IIAPSPVK 8 0 Q9HCS5 Q9HCS5 EPB41L4A Band 4.1-like protein 4A 1 IIAPS(1)PVK;IIAPS(1)PVK 82.029 0.042305 9210200.0 187343.0 191176.0 200158.0 223381.0 211994.0 148248.0 204038.0 192836.0 144338.0 191440.0 True False 176931.22605344944 205838.58447227275 187280.05219555282 192956.12244628166 185361.41846959386 168667.81633864524 213526.17129362686 193397.12083428164 173209.63314068152 185912.629779145 0.9516901905138719 1.1071791341814636 1.0073551883916239 1.0378860364435918 0.9970351056288862 0.9072423779869837 1.1485296698093366 1.0402581097584809 0.9316722233795841 1.0 17.504265255994994 -6.254449805396066 23.33343666291981 1.0085121311007654 1.0304904259616667 0.018894144114464995 0.07046800771163272 1292.5538877040142 4314957.924538032 0.021228609376916018 0.026795177364966945 5.566089619277814e-07 6.254449805396066 0.021978294860901304 IIAPSRGS(ph)PLPVLSWANR ddPTM_A459_Selumetinib_30min_R2 1 IIAPSRGSPLPVLSWANR 18 1 I3L413;C9J2U0;P24864-2;P24864-3;P24864;I3L1Q9 I3L413 CCNE1 G1/S-specific cyclin-E1 1 IIAPS(0.017)RGS(0.958)PLPVLS(0.025)WANR 53.718 0.04081 1694600.0 6372.1 6848.9 7745.3 6478.0 8562.2 5909.7 4677.8 5189.1 4014.5 6020.7 True False 6017.964191537363 7374.188607315517 7246.9758304450215 5595.6852248266905 7486.539888960806 6723.707532084694 4895.326968884855 5204.199421898251 4817.512174501975 5846.866747342764 1.0292630996374867 1.2612205692334066 1.2394631421587583 0.9570399782703739 1.2804362083954157 1.1499676361087636 0.8372564623795545 0.8900834663734064 0.8239476599481934 1.0 12.513447996701055 -7.254771682061226 23.556808922886145 0.8786621789222808 1.1586514744196545 0.6068465181040461 0.1043589254359511 152.3542143149206 538265.4332944384 0.0395072391806511 0.02983169740981496 5.561965849152723e-08 7.254771682061226 0.2799892954973737 IIEDGDGAGAET(ph)PVIENR ddPTM_A459_Selumetinib_30min_R1 2 IIEDGDGAGAETPVIENR 18 0 A0A5H1ZRS1;Q15154-5 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 IIEDGDGAGAET(1)PVIENR;IIEDGDGAGAET(1)PVIENR 230.48 1.7191999999999999e-18 37906000.0 6798.4 7704.7 7458.3 7822.299999999999 7983.299999999999 6729.299999999999 7369.5 6259.5 3993.8999999999996 5917.8 True False 6956.789492616368 6802.630142182147 6445.503825509366 6456.282147756673 7261.211924566088 6661.60935171554 6813.612681781515 6093.477726278484 6777.356597085327 6677.407274253388 1.0418399248223509 1.0187532170475195 0.965270435182501 0.9668845829803845 1.0874298401063123 0.9976341232623683 1.0203979481756795 0.9125514553790349 1.0149682831564464 1.0 12.705072321691903 IIEDGDGAGAET(ph)PVIENR ddPTM_A459_Selumetinib_30min_R2 4 IIEDGDGAGAETPVIENR 18 0 A0A5H1ZRS1;Q15154-5 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 IIEDGDGAGAET(1)PVIENR;IIEDGDGAGAET(1)PVIENR;IIEDGDGAGAET(1)PVIENR;IIEDGDGAGAET(1)PVIENR 240.34 1.1359999999999999e-24 36810500.0 67754.0 63543.0 75496.0 78182.0 82561.0 71270.0 64078.0 59884.0 50936.2 64453.0 True False 63988.50392075174 68416.54377705182 70638.66955382981 67533.47672852746 72188.94907529533 81086.7955753551 67057.75396814826 60058.252525670134 61124.8632763401 62592.07442099476 1.0223100051032754 1.0930544227833325 1.1285561344190893 1.078946134206973 1.1533241187974044 1.2954802397179668 1.0713457668317128 0.9595184866652267 0.9765591545219258 1.0 15.933692370295029 -7.598313364455382 5.05376038309183 0.9786741306086821 1.1301345479477416 0.5002386413019748 0.06680938936871543 0.18260755493235184 8.468728637318154 0.03493923423670983 0.019731285766998792 2.521660615903892e-08 7.598313364455382 0.15146041733905946 IIEDQQESLNK ddPTM_A459_Selumetinib_30min_R2 2 IIEDQQESLNK 11 0 P05455 P05455 SSB Lupus La protein 0 ; 187.99 0.00026881 5174500.0 33560.0 29258.0 33491.0 31125.0 37927.0 31012.0 29659.0 30982.0 23595.0 32917.0 False True 31694.86955132435 31501.99452070222 31336.225522243698 26885.72130638019 33162.27118831802 35283.621501093214 31038.202268193552 31072.152490653807 28314.659299383246 31966.60068136293 0.9914995300017309 0.9854658878092227 0.980280194150054 0.8410566257692524 1.0374037427023697 1.1037652033381256 0.9709572368227865 0.972019289769819 0.8857575937341118 1.0 14.964277716070592 -5.286135204041939 5.767853831292808 0.9749091875310193 0.9886298619681787 0.007155147150828767 0.06860559304924166 1.7640761629936055 203.41265544260233 0.019305301618919447 0.04354254684214183 5.1744571628730026e-06 5.286135204041939 0.013720674437159408 IIEQLS(ph)PQAATSR ddPTM_A459_Selumetinib_30min_R2 2 IIEQLSPQAATSR 13 0 Q03468;P0DP91;D6R9X7 Q03468 ERCC6 DNA excision repair protein ERCC-6 1 IIEQLS(0.929)PQAAT(0.027)S(0.044)R;IIEQLS(1)PQAATSR 139.21 0.0009469 16469700.0 53273.0 55203.0 74069.0 64266.0 68490.0 49578.0 55631.0 60631.0 48423.0 65215.0 True False 50312.29992871577 59436.89259437845 69303.48118022957 55512.8599349664 59885.67389163138 56406.9194757255 58217.951730735236 60807.42617199762 58108.95305166496 63332.07350108094 0.7944205383999792 0.9384959201338007 1.0942872599781013 0.87653627721535 0.94558208157529 0.8906532876230993 0.9192491025853051 0.9601363544643737 0.9175280365749144 1.0 15.950648693769448 IIFEDDR ddPTM_A459_Selumetinib_30min_R2 2 IIFEDDR 7 0 D6RC06;D6REP8;D6RE99;D6RD60;P49773 D6RC06 HINT1 Histidine triad nucleotide-binding protein 1 0 ; 148.21 0.039083 50841000.0 236249.0 223017.0 251469.0 258453.0 265339.0 218665.0 181824.0 206261.0 187347.0 222899.0 False True 223119.22635967913 240121.68678732074 235289.75831874585 223251.25554370644 232004.74265924311 248784.11890676373 190279.17627742086 206861.18536165307 224821.63491254693 216463.32670884635 1.030748393975231 1.1092950036303195 1.0869728461450745 1.0313583318618686 1.071796992990414 1.1493130161553435 0.8790365516896799 0.9556407937862443 1.038613045132319 1.0 17.723763098202184 -7.256772417304034 24.999805153363713 0.9646259976400169 1.0789944043844322 0.5469415971279594 0.04970600118062821 304.72031475169564 1632319.5836338038 0.01954387800690043 0.014615593499832475 5.536401564461303e-08 7.256772417304034 0.11436840674441529 IIGEDS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 IIGEDSPSR 9 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 IIGEDS(0.999)PS(0.001)R 147.28 0.0016555999999999995 8968500.0 3403.0 4334.6 2414.9 2748.8 3135.3 2619.6 3635.7 3847.3 1857.6 3401.8 True False 3482.283278914674 3827.103016899132 2086.9698440961843 2268.773681366548 2851.7126685821745 2593.2492024064936 3361.4562218811357 3745.2571062083557 3152.21152626398 3838.45416633803 0.9072098110362092 0.9970427810397102 0.5437006028099065 0.59106441891711 0.7429325830149931 0.6755972821424908 0.8757317597693342 0.9757201581441348 0.8212190089197442 1.0 11.906309706137804 -7.420179876743158 4.981295213054713 0.924388061636836 0.7391649130236343 0.2978818967086919 0.13348104451463824 0.32494610890062187 12.480011745876707 0.0634466418620757 0.04162046816251852 3.800319615088506e-08 7.420179876743158 -0.18522314861320166 IIGEDS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 IIGEDSPSR 9 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 IIGEDS(0.97)PS(0.03)R;IIGEDS(0.827)PS(0.173)R 133.91 0.0030091 36790000.0 116458.0 88319.0 114989.0 123727.0 135517.0 98232.0 122990.0 129402.0 105832.0 94449.0 True False 109985.7305783115 95092.78330965541 107590.73293055703 106875.16915902021 118492.14292264862 111762.56633868795 128709.27870006162 129778.53839634577 127001.35719314803 91722.01196202719 1.199120344458269 1.0367498627158738 1.1730088626392046 1.1652074226551683 1.291861575950866 1.2184923111472687 1.4032539839329639 1.414911596684926 1.3846333554668038 1.0 16.484980380955328 -6.277948657011334 1.2913473095118968 1.3236311379199899 1.1198178091108986 0.22604757366494144 0.12149059842150478 0.5209131978510101 1.7681522366083207 0.046700765748190376 0.06565858729602396 5.272921950653023e-07 6.277948657011334 -0.2038133288090913 IIGEDS(ph)PSRLDR ddPTM_A459_Selumetinib_30min_R1 1 IIGEDSPSRLDR 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 IIGEDS(0.973)PS(0.027)RLDR 89.74700000000001 0.013944 34197000.0 3332.3 3336.8 3832.9 3538.0 3843.5 2617.1 3158.5 2606.6 1792.5 2631.1 True False 3409.936106472923 2946.125904763765 3312.4132326126405 2920.154716485318 3495.8561036250394 2590.774350136676 2920.251802077062 2537.4645005699344 3041.741580979858 2968.827314084304 1.148580144859208 0.9923534086294471 1.1157311901902625 0.9836054467135626 1.1775208638914354 0.8726591600144201 0.9836381483770388 0.8547026256906365 1.0245599555587637 1.0 11.535677464089838 -6.770738417855846 24.999998173851843 0.9403137821754259 1.074725740163724 0.44517356962316934 0.07565328726528142 177.8896921125104 478244.6498529568 0.024359165255847474 0.021771737143196322 1.6953586331671517e-07 6.770738417855846 0.13441195798829808 IIGEDS(ph)PSRLDR ddPTM_A459_Selumetinib_30min_R2 1 IIGEDSPSRLDR 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 IIGEDS(0.971)PS(0.029)RLDR 109.95 0.004081800000000001 41793000.0 54241.0 52489.0 56317.0 60615.0 79463.0 44054.0 46970.0 44105.0 37550.0 55577.0 True False 51226.50236392679 56514.73752126388 52693.62553331343 52359.13243329268 69480.14753176666 50122.03861760479 49154.19806928933 44233.33824802418 45061.04923466165 53972.3476036123 0.9491249619184299 1.0471054165796823 0.9763078293408662 0.9701103390542224 1.2873286157950343 0.9286614505953079 0.9107292947546254 0.819555572658909 0.834891407088725 1.0 15.719932820286532 -6.983960870207163 24.999859285208426 0.8824624425012574 1.0449722598516151 0.35691241458484724 0.09953960990047725 259.68574809471727 404765.3576550705 0.03547030126990164 0.03127347876951497 1.0376219010052895e-07 6.983960870207163 0.16250981735035774 IIGEDSPS(ph)RLDR ddPTM_A459_Selumetinib_30min_R1 1 IIGEDSPSRLDR 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 IIGEDS(0.168)PS(0.832)RLDR 97.631 0.008812799999999999 5738200.0 987.7 1185.1 1418.3 1335.0 1223.0 1046.5 1033.0 910.47 624.42 828.36 True False 1010.7114882703564 1046.3479410619575 1225.7026501642383 1101.867311053675 1112.3798659381875 1035.9731601459748 955.079978326929 886.3213779766394 1059.5951341676114 934.6880749096864 1.0813355978335508 1.119462170481912 1.3113494042198741 1.1788609918449449 1.1901081182036803 1.1083624451355871 1.021816800668194 0.9482536492853828 1.1336350196508007 1.0 9.868341177382547 -7.039603661802634 2.835208239779722 1.0217867239005523 1.180522365536474 0.5021381048521355 0.07027890508692562 0.23045017077236704 3.6965105952347366 0.029700694604371067 0.023309187975351954 9.128435225561313e-08 7.039603661802634 0.1587356416359218 IIIEELSLVAAS(ph)PTLSPR ddPTM_A459_Selumetinib_30min_R1 1 IIIEELSLVAASPTLSPR 18 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;H0Y5V5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 IIIEELS(0.086)LVAAS(0.908)PT(0.006)LSPR 207.21 1.8208e-11 58200000.0 2348.9 2909.7 3193.9 2939.2 2914.4 2477.2 2544.7 2432.2 1410.4 2105.3 True False 2403.624799836224 2569.0309713171696 2760.18592283689 2425.9238956171985 2650.793034579113 2452.281617117639 2352.751230250277 2367.6901551009714 2393.345788459689 2375.5357623585896 1.0118242957747543 1.0814532923581268 1.1619214353971223 1.021211271182287 1.1158716600196452 1.0323067562169013 0.9904086764470804 0.9966973314475264 1.0074972670937257 1.0 11.214037210539038 -6.975142270659504 5.269984504246382 0.9997216407724933 1.0800218327798592 0.4659332817003691 0.04035954957192767 0.16214842243054894 12.56303614414143 0.014648613755538652 0.012527642412210717 1.0589067807628686e-07 6.975142270659504 0.08030019200736593 IIIEELSLVAAS(ph)PTLSPR ddPTM_A459_Selumetinib_30min_R2 2 IIIEELSLVAASPTLSPR 18 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;H0Y5V5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 IIIEELSLVAAS(0.878)PT(0.096)LS(0.026)PR;IIIEELS(0.001)LVAAS(0.874)PT(0.104)LS(0.021)PR 118.31 0.001 2675600.0 33501.4 27222.2 34047.2 35052.6 37330.0 27385.7 35155.0 34381.8 24620.6 32644.2 True False 31639.526304729978 29310.05520683095 31856.640219788478 30278.37541089227 32640.271665565746 31157.831592367093 36789.77715831095 34481.84534578662 29545.407957041527 31701.677126182432 0.9980395099853842 0.9245585049071036 1.0048881670515173 0.9551032675771385 1.029607094149859 0.9828448970806603 1.160499396037513 1.0876978277375755 0.9319824891106457 1.0 14.952271545391204 -6.592695270741502 1.7989949850857303 1.0490217296144886 0.9700164099794378 0.17212519151216876 0.06199007441297562 0.5327399399841224 3.5212939912944776 0.02448824913620596 0.025348978998874023 2.5544930724809664e-07 6.592695270741502 -0.07900531963505075 IIIEELSLVAASPT(ph)LSPR ddPTM_A459_Selumetinib_30min_R1 1 IIIEELSLVAASPTLSPR 18 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;H0Y5V5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 IIIEELSLVAAS(0.02)PT(0.98)LSPR 294.29 8.758399999999997e-81 61816000.0 1284.0 1452.9 1724.6 1667.2 1322.1 1173.8 1626.3 1548.4 791.74 1379.7 True False 1313.914701770919 1282.7937925651154 1490.4087925497029 1376.05481721999 1202.5162884357126 1161.9926377251268 1503.6268816583586 1507.331402087964 1343.5249535983226 1556.7979344160676 0.8439853835390329 0.8239950504856449 0.9573553250561921 0.8839007213457848 0.7724292676986105 0.7463991389229158 0.965845886879563 0.9682254637968429 0.863005354707295 1.0 10.604365985704597 -7.293598524871828 24.99321566312071 0.9466213180507324 0.8419033924245202 0.4249364318854668 0.063279482304268 767.0355336516856 596116.2404321788 0.02854737539486267 0.01924837587204978 5.0862941791832334e-08 7.293598524871828 -0.10471792562621218 IIIEELSLVAASPT(ph)LSPR ddPTM_A459_Selumetinib_30min_R2 1 IIIEELSLVAASPTLSPR 18 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;H0Y5V5 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 IIIEELSLVAAS(0.024)PT(0.975)LS(0.001)PR 257.72 4.303999999999999e-42 58733000.0 62776.0 55710.0 86253.0 72759.0 87046.0 48693.0 57273.0 62581.0 45476.0 70214.0 True False 59287.16123223892 59982.77786411649 80703.57588516566 62849.09868372412 76110.50327888662 55400.01875895564 59936.3079842965 62763.10034915774 54572.47070560509 68186.73938211924 0.8694822742585331 0.8796839151960668 1.1835670192836458 0.921720253134808 1.1162068162896384 0.8124749659679915 0.8790024061483974 0.9204590352595192 0.8003384705020189 1.0 16.05720357792223 -6.779988643223484 24.99815798631569 0.8772678925102574 0.994275159247621 0.2174609052286539 0.10569547791245432 378.07639832702705 509516.37736905366 0.036840550071911456 0.032545980292591085 1.659630306110203e-07 6.779988643223484 0.11700726673736361 IIILDEADS(ph)MTDGAQQALRR ddPTM_A459_Selumetinib_30min_R2 1 IIILDEADSMTDGAQQALRR 20 1 A0A087WVY3;P35250 A0A087WVY3 RFC2 Replication factor C subunit 2 1 IIILDEADS(0.5)MT(0.5)DGAQQALRR 51.535 0.033486 5310900.0 3122.0 930.38 3544.4 3336.5 3144.3 1162.7 2639.1 1472.3 3054.0 3837.5 True False 2948.4917383562156 1001.7371543567889 3316.3571628509335 2882.0629442164645 2749.2849236013503 1322.8513710602704 2761.823379277441 1476.5841492476134 3664.8853358896563 3726.7014039775845 0.7911800326179151 0.2687999508862219 0.8898907648762302 0.7733549409513678 0.7377261083131003 0.3549657532659751 0.7410905999417314 0.3962174559173496 0.9834126587061817 1.0 11.863683514714037 -8.290863252466501 21.791458205185634 0.9917080527857076 0.6208502262912577 0.3581154740276038 0.19949984582191438 180.48582338154822 133662.12955236464 0.18572309976997312 0.04802281147055353 5.118429756170031e-09 8.290863252466501 -0.37085782649444987 IILDLISES(ph)PIK ddPTM_A459_Selumetinib_30min_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 IILDLIS(0.005)ES(0.995)PIK 136.33 0.0014159 42186000.0 1360.5 1762.8 1136.5 1381.9 1055.0 1088.0 1480.9 1678.0 715.87 1390.6 True False 1392.1970029278318 1556.4105564965128 982.1695423476394 1140.5771064757105 959.5754362753781 1077.05570782496 1369.19452072057 1633.4939890878347 1214.779104923878 1569.0970555910592 0.8872599677420264 0.991914777324104 0.6259456920449503 0.7269002911015402 0.6115462602241122 0.6864175189081894 0.8726002740504867 1.0410407586116577 0.7741899078806734 1.0 10.615718876795595 -10.396113263988248 6.452549766453914 1.0000000107125422 0.8002885857625862 0.15481231278844676 0.13875443065246545 2.3439865925431445e-08 4.082752308513444e-09 0.14732722720580174 0.035732099537880514 4.016860374801972e-11 10.396113263988248 -0.19971142494995597 IILDLISES(ph)PIKGR ddPTM_A459_Selumetinib_30min_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 IILDLIS(0.01)ES(0.99)PIKGR 96.096 0.0066195 4674000.0 719.89 560.76 549.43 618.53 590.2 534.66 559.78 504.01 302.9 515.84 True False 736.6620363379028 495.1059585097488 474.820423802959 510.5153467460897 536.8165142082732 529.2818058324387 517.5553439185363 490.64201754479114 513.9991770593023 582.0530887070986 1.2656268828917885 0.8506199316105624 0.8157682400718239 0.8770941287848604 0.9222810163256614 0.9093359628210556 0.8891892405693961 0.8429506295287311 0.88307954554633 1.0 9.185006936244111 -4.7585799535210285 24.999994526975463 0.8821117119343752 1.265627398883474 0.8464298354572438 0.0482238392188785 27.799937311763195 243010.20397063767 0.011808386295099024 0.0799127184119658 1.743492351349996e-05 4.7585799535210285 0.3835156869490989 IILDLISES(ph)PIKGR ddPTM_A459_Selumetinib_30min_R2 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 IILDLIS(0.077)ES(0.923)PIKGR 73.252 0.027228 21159000.0 24087.0 33584.0 30729.0 35317.0 32561.0 25664.0 25540.0 23581.0 19101.0 28574.0 True False 22748.34096790077 36159.78481041982 28751.92959520548 30506.76367477682 28470.396080966693 29198.983045403584 26727.66060654992 23649.616805955287 22921.733726531875 27748.99437583204 0.8197897430010442 1.3031025312367048 1.0361431194871316 1.0993826753356748 1.0259973999548955 1.0522537375565009 0.9631938456778222 0.8522693285978283 0.8260383571411704 1.0 14.760147868659455 -7.415767816029639 2.34506787984351 0.8797541197053818 1.0695140985302016 0.2743067687236954 0.11814098861035598 0.3497071630857845 3.7606487873527747 0.05853584396530382 0.034124328916322486 3.839124391906774e-08 7.415767816029639 0.18975997882481987 IILWDHDLNPER ddPTM_A459_Selumetinib_30min_R1 1 IILWDHDLNPER 12 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 0 157.03 0.00061939 5655700.0 1616.5 1942.3 2060.0 1898.0 1780.4 1490.2 1762.9 1891.2 1126.6 1504.0 False True 1654.1613048385448 1714.8946130492275 1780.263314770027 1566.5499298725663 1619.3631343551506 1475.2099409933426 1629.9230336810679 1841.0392325166335 1911.757916391581 1697.0530502005984 0.974725748639983 1.0105132617077115 1.0490322117859503 0.9231001527544433 0.95422069107606 0.8692774458753466 0.9604431832513454 1.0848448328112168 1.1265162960966975 1.0 10.728815949168506 -7.7604455380403365 24.989835169327048 1.0792604493354652 0.9626954455563312 0.4544491673219663 0.05366883092972296 23.5846222160151 593079.8748756077 0.028739114804740326 0.0153664775871342 1.7360189517209718e-08 7.7604455380403365 -0.11656500377913392 IINEPT(ph)AAAIAYGLDR ddPTM_A459_Selumetinib_30min_R1 1 IINEPTAAAIAYGLDR 16 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066 A0A0G2JIW1;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 1 IINEPT(1)AAAIAYGLDR 102.84 0.011049 1174600.0 291.49 333.84 469.77 538.96 322.32 439.34 316.68 419.07 245.8 350.64 True False 298.2811498591941 294.7538576019944 405.9778142619009 444.840753532201 293.16621291021795 434.9206384888033 292.7925726394693 407.9549022687952 417.1046474782981 395.6480595228311 0.7539052515989444 0.7449900246129868 1.02610844282044 1.1243344756162799 0.7409772545423052 1.0992613966395708 0.7400328792022637 1.0311055304070156 1.0542315005445613 1.0 8.6280738712408 -5.253096315912452 24.319306839112254 0.970852356887154 0.7494475861010645 0.3393749587802525 0.1267639268902283 478.191319803942 1393873.7138138688 0.03140094386359001 0.08005458527789548 5.583463534161162e-06 5.253096315912452 -0.22140477078608944 IINEPTAAAIAYGLDK ddPTM_A459_Selumetinib_30min_R2 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PI65;P54652;P11021;Q53FA3;P34931 P11142;P54652;P11021;Q53FA3 HSPA8;HSPA2;HSPA5;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;78 kDa glucose-regulated protein;Heat shock 70 kDa protein 1-like 0 180.27 1.4178e-05 2679500.0 11100.0 11502.0 13398.0 14196.0 13562.0 10308.0 11690.0 13140.0 10822.0 12485.0 False True 10483.106436820628 12384.166415240858 12535.987266639426 12262.480310534078 11858.220314181695 11727.833433292553 12233.608163295556 13178.235224555894 12986.702391944293 12124.525610074303 0.8646199260868553 1.021414512494478 1.0339363097409138 1.0113781524239718 0.9780358172800316 0.9672818393445318 1.0089968512360283 1.0869072859729918 1.0711101456335417 1.0 13.565640680384707 -7.584813495710305 5.490487745560541 1.0585744808651127 0.9853764783714073 0.30506872014609343 0.04869403845680012 0.24880453179426185 14.806099974467022 0.023486316619482438 0.013375643647677859 2.6012764206767916e-08 7.584813495710305 -0.07319800249370545 IINEPTAAAIAYGLDKK ddPTM_A459_Selumetinib_30min_R1 2 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;E9PN89;E9PI65;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 ; 130.01 0.0012096 31295000.0 3902.7 4618.6 5462.4 5461.2 4540.9 4641.7 4426.9 4489.2 2820.64 3547.36 False True 3993.625316667733 4077.8521648711144 4720.6360828154375 4507.503939420471 4130.17639676101 4595.0087123263975 4092.9753688823635 4370.131833023302 4786.420068605312 4002.698210212498 0.9977333056182911 1.0187758233850528 1.179363478058673 1.126116360189237 1.0318480634446194 1.1479778067211455 1.0225540757580804 1.0917964841499497 1.195798388295481 1.0 11.966757130204453 -5.070081697654763 10.13077560315419 1.1002336268695951 1.0029396664755934 0.25602719090138293 0.06260970521673667 0.6434875818605865 90.79905722332947 0.015409840894859386 0.04098171602094801 8.50977940746618e-06 5.070081697654763 -0.09729396039400173 IINEPTAAAIAYGLDKK ddPTM_A459_Selumetinib_30min_R2 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;E9PN89;E9PI65;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 226.22 4.871000000000002e-16 45239000.0 100350.0 106600.0 88654.0 96965.0 93481.0 63140.0 74039.0 69636.0 58568.0 88593.0 False True 94772.9487328784 114775.87722697582 82950.09815917685 83758.19972604493 81737.08104925667 71836.96187214719 77481.96020549515 69838.62923113967 70283.23652664875 86035.08989774215 1.1015615703490487 1.3340588981006916 0.9641426336366709 0.9735353310561605 0.9500435362641694 0.8349728228043897 0.9005855668609994 0.8117458738538782 0.8169136175737665 1.0 16.39263757071776 -5.417668394754131 4.290945946918277 0.8942375402461974 1.2158179139767624 0.7071435605388767 0.08075970855124157 0.11406995176633523 3.5058266661606656 0.021789166211092868 0.047515845551783654 3.822360154856538e-06 5.417668394754131 0.32158037373056503 IINEPTAAAIAYGLDKR ddPTM_A459_Selumetinib_30min_R2 2 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 ; 152.9 0.00052616 1841000.0 12590.6 14316.599999999999 13898.1 14260.2 14535.6 11070.2 12097.3 12000.8 7655.5 12314.6 False True 11890.86485616521 15414.63718487543 13003.911377107144 12317.936159782896 12709.50797808726 12595.019564729857 12659.848420345183 12035.720341160615 9186.813912542 11959.045500826684 0.9942988222047687 1.28895213115544 1.0873703404011827 1.0300099752050782 1.062752706911994 1.05317933307129 1.0586002385784095 1.006411451509958 0.7681895609400391 1.0 13.545814626428578 -7.999865390163913 3.7633924862923824 0.8814571318960535 1.085410132220112 0.42408106980716886 0.09100506511583242 0.20121052485968038 6.1869847446670425 0.061606131060097144 0.023942515559206422 1.0003099986415943e-08 7.999865390163913 0.2039530003240585 IIPELVGS(ph)PTQSTSSR ddPTM_A459_Selumetinib_30min_R1 2 IIPELVGSPTQSTSSR 16 0 Q9NSI6-3;Q9NSI6-2;Q9NSI6;H7C409 Q9NSI6-3 BRWD1 Bromodomain and WD repeat-containing protein 1 1 IIPELVGS(0.981)PT(0.019)QSTSSR;IIPELVGS(0.991)PT(0.003)QS(0.001)T(0.001)S(0.001)S(0.003)R 117.13 0.001866 13756800.0 2655.2 2948.3999999999996 3076.3999999999996 3592.8 3054.6 2922.7 2683.5 2484.93 1815.29 2212.85 True False 2717.0609938801745 2603.1999573260273 2658.6417774555894 2965.3849252087216 2778.311969333431 2893.300291599275 2481.0814345017548 2419.0215842097914 3080.4145464641156 2496.890852484305 1.0881777195734483 1.0425765926996564 1.064780935382237 1.1876309780454697 1.1127086178272965 1.1587612204676703 0.9936683584038843 0.9688135073277084 1.23370012085199 1.0 11.285917042243284 -7.260409975668532 24.999942786503755 1.0464466240640176 1.1078002403480438 0.12290377502755057 0.07843309204288984 208.5695892206246 5065377.884653221 0.031482584299405515 0.022882835643613996 5.490223499327087e-08 7.260409975668532 0.06135361628402625 IIPELVGS(ph)PTQSTSSR ddPTM_A459_Selumetinib_30min_R2 1 IIPELVGSPTQSTSSR 16 0 Q9NSI6-3;Q9NSI6-2;Q9NSI6;H7C409 Q9NSI6-3 BRWD1 Bromodomain and WD repeat-containing protein 1 1 IIPELVGS(0.902)PT(0.095)QS(0.001)T(0.001)S(0.001)S(0.001)R 152.34 0.00017489 8859700.0 9491.6 6844.7 8046.4 10997.0 10644.0 5955.8 7753.3 9995.0 5976.2 9158.0 True False 8964.094869885286 7369.666480820644 7528.703384257916 9499.189629116883 9306.805561432673 6776.157388630566 8113.843812872487 10024.08379523867 7171.606988979621 8893.584744658425 1.007928200748209 0.8286497168924981 0.8465319216505729 1.0680945762418457 1.0464627963456954 0.7619151987842016 0.9123254622097959 1.127113990931411 0.8063797889019901 1.0 13.11854932924268 -14.522878742600295 0.13930581553745516 1.204083979454462 0.9139426758645156 0.016648160181947702 0.11834856887247731 746.6344579840801 6.362769413669864 43.06177918696511 0.7538230545462774 3.0000000185130814e-15 14.522878742600295 -0.2901413035899464 IIPELVGSPT(ph)QSTSSR ddPTM_A459_Selumetinib_30min_R2 1 IIPELVGSPTQSTSSR 16 0 Q9NSI6-3;Q9NSI6-2;Q9NSI6;H7C409 Q9NSI6-3 BRWD1 Bromodomain and WD repeat-containing protein 1 1 IIPELVGS(0.07)PT(0.872)QS(0.021)T(0.006)S(0.021)S(0.009)R 163.9 6.6799e-05 8967600.0 13126.0 12949.0 14222.0 14031.0 16479.0 11833.0 11489.0 10369.0 10720.0 14231.0 True False 12396.509467541215 13942.146662402514 13306.972003742794 12119.953595174951 14408.76069587082 13462.888340720889 12023.26126502161 10399.172073319642 12864.299541826174 13820.114053421508 0.8969903880404051 1.008830072495009 0.9628699120936941 0.8769792744347402 1.0425934721069525 0.9741517536454644 0.8699827815129324 0.7524664437009527 0.9308388839700857 1.0 13.75448190147147 -7.26714501493065 22.236600686461713 0.867694195008993 0.9626598827472824 0.16312786585585193 0.07421696113532765 139.19821535980546 542488.0898799858 0.029476575653341136 0.020562945731026298 5.405737902351508e-08 7.26714501493065 0.0949656877382894 IIPELVGSPTQSTSS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 IIPELVGSPTQSTSSR 16 0 Q9NSI6-3;Q9NSI6-2;Q9NSI6;H7C409 Q9NSI6-3 BRWD1 Bromodomain and WD repeat-containing protein 1 1 IIPELVGS(0.003)PT(0.001)QS(0.001)T(0.001)S(0.08)S(0.915)R;IIPELVGS(0.289)PT(0.12)QS(0.056)T(0.007)S(0.017)S(0.51)R 207.05 7.444e-08 32570000.0 3887.56 4671.18 4897.33 5697.3 5002.38 4099.01 4639.3 4407.8 2589.7799999999997 3425.87 True False 3978.132584125043 4124.276074027336 4232.299485108107 4702.373506566369 4549.915612241922 4057.7776810032988 4289.3538658781445 4290.89082544777 4394.667509952586 3865.613785299685 1.0291076152649417 1.0669136398755878 1.0948583382030739 1.216462318209012 1.177022813180284 1.0497110954111304 1.109617800461566 1.1100153982700875 1.1368615060989302 1.0 11.916481789291822 -5.178655455396082 2.75008629701071 1.120125924377759 1.0370386904234232 0.17034564330101687 0.057401504191538125 0.46347544122973755 6.597091357419617 0.015591363786195819 0.05656310534328509 6.627420771600143e-06 5.178655455396082 -0.08308723395433582 IIPELVGSPTQSTSS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 IIPELVGSPTQSTSSR 16 0 Q9NSI6-3;Q9NSI6-2;Q9NSI6;H7C409 Q9NSI6-3 BRWD1 Bromodomain and WD repeat-containing protein 1 1 IIPELVGS(0.001)PT(0.002)QS(0.002)T(0.002)S(0.038)S(0.955)R;IIPELVGS(0.265)PT(0.116)QS(0.016)T(0.002)S(0.052)S(0.549)R 150.92 0.00021606 9525100.0 34142.7 31086.9 37143.1 37254.5 46084.0 37408.6 30437.9 39535.0 37347.0 36527.0 True False 32245.185418057266 33471.165269861856 34753.353384349524 32180.372832402907 40294.51592381281 42561.29508853977 31853.322661554652 39650.040304628405 44817.443562367705 35472.37060145647 0.9090225680246278 0.9435841107413204 0.9797302180566014 0.9071954393451677 1.1359408813280258 1.1998435505404943 0.8979755827271036 1.11777249821021 1.263446530425219 1.0 15.114408127659662 -6.261142940322087 24.99999176756173 1.1030264408715038 0.9387079483603837 0.42099509121098644 0.0962549407363289 28.61669200403764 2413353.059705388 0.029712770205459874 0.036023402642170126 5.480965389807472e-07 6.261142940322087 -0.16431849251112007 IIPGFMCQGGDFTR ddPTM_A459_Selumetinib_30min_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 ; 266.26 5.8186e-35 623340000.0 1668.0 1715.1599999999999 1725.21 1919.77 1654.76 1650.5900000000001 1289.6799999999998 1314.3600000000001 684.3 1250.0900000000001 False True 1706.861154636988 1514.3482698437483 1490.9359579001946 1584.5182080460772 1505.0872501716067 1633.9865632158103 1192.3983992726753 1279.4989031570233 1161.207120705448 1410.5512284077574 1.2100667599032953 1.0735861550758123 1.0569881673728192 1.123332620705095 1.0670206227607646 1.1584028501114905 0.8453421437367185 0.9070914103568807 0.8232293144122307 1.0 10.462043347343977 -7.262842127362587 24.99999487015413 0.8861733272061229 1.1085963253864481 0.7561838923931823 0.06134735042884736 59.85964417408872 1066811.186894311 0.02349409968556442 0.01681162462462605 5.459562884226883e-08 7.262842127362587 0.2224229981803253 IIPTLEEGLQLPSPT(ph)ATSQLPLESDAVECLNYQHYK ddPTM_A459_Selumetinib_30min_R1 1 IIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYK 36 0 P61978;P61978-2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 IIPTLEEGLQLPS(0.026)PT(0.595)AT(0.315)S(0.065)QLPLESDAVECLNYQHYK 142.34 5.0071e-35 87921000.0 996.81 1174.9 1135.0 1440.2 1191.6 1314.3 1126.6 1154.6 683.35 1055.3 True False 1020.0337335453818 1037.3421618038092 980.873234108729 1188.6961059022485 1083.8199903940672 1301.07933528892 1041.6196549691367 1123.9762573306393 1159.5950400907038 1190.7580344924809 0.8566255309628338 0.8711611694024304 0.8237384974074872 0.9982683899411091 0.9101933046002983 1.0926479583599533 0.874753413201273 0.9439165848750246 0.9738292805934674 1.0 10.217664567803117 -5.760627114889407 24.99999993437859 0.966764090090987 0.8525736633922444 0.4898943630255259 0.056013778229228144 18.599113962512895 572405.8188720103 0.015069781576256007 0.02426680400293302 1.7352932805987647e-06 5.760627114889407 -0.11419042669874258 IIS(ph)IFSGTEK ddPTM_A459_Selumetinib_30min_R1 2 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 IIS(0.756)IFS(0.143)GT(0.101)EK;IIS(0.737)IFS(0.263)GTEK 134.49 0.0020927 16196200.0 5926.8 4655.3 5412.1 5263.0 4037.3 5799.8 4062.3 4725.8 4225.9 3576.3 True False 6064.882908454742 4110.255311809744 4677.166546537314 4343.915848745687 3672.1269278432083 5741.459277797066 3755.8774404235064 4600.456432438194 7171.043652475748 4035.352941111969 1.5029374126525654 1.0185615414043896 1.1590477003601298 1.0764649120254377 0.909989034771102 1.422789867846099 0.930743232434224 1.1400381824273607 1.7770548839526583 1.0 11.97847914506081 -8.063007488700144 24.999050318613065 1.4118678098379414 1.1328284688067962 0.1278837195112782 0.2512910704731374 371.03084214069554 147208.54432401736 0.15632129291945154 0.05908401869221218 8.64953003943013e-09 8.063007488700144 -0.27903934103114514 IIS(ph)NASCTTNCLAPLAK ddPTM_A459_Selumetinib_30min_R1 2 IISNASCTTNCLAPLAK 17 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 IIS(0.99)NASCT(0.01)TNCLAPLAK;IIS(0.998)NAS(0.001)CT(0.001)TNCLAPLAK 222.96 3.3519999999999994e-12 192053000.0 8388.7 14649.8 14276.3 15653.2 13659.4 11094.3 13256.4 14835.800000000001 5324.200000000001 9475.599999999999 True False 8584.140388431237 12934.594605492755 12337.656874102595 12919.662466955338 12423.909681762943 10982.701414818435 12256.459075211136 14442.306390529962 9034.778535817555 10691.8855601601 0.8028649708352001 1.20975804807427 1.1539271351794986 1.208361461994724 1.161994263019114 1.0271996789548485 1.1463327966098813 1.3507726311946893 0.8450126486092195 1.0 13.384228680541518 -8.28780176785596 24.987916426809026 0.9225062957558728 1.1363735713826693 0.26793006256761254 0.13883650220271265 1115.927449088328 1057734.8115527867 0.128850720983155 0.03330841684790425 5.154638725117391e-09 8.28780176785596 0.21386727562679642 IIS(ph)NASCTTNCLAPLAK ddPTM_A459_Selumetinib_30min_R2 2 IISNASCTTNCLAPLAK 17 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 IIS(0.858)NASCT(0.071)T(0.071)NCLAPLAK;IIS(1)NASCTTNCLAPLAK 188.44 6.4593e-08 63015000.0 144630.0 123854.0 141118.0 141468.0 160833.0 109773.0 125091.0 130228.0 111703.0 143315.0 True False 136592.04359976278 133353.20354662155 132038.62151766097 122199.81435408801 140627.7206747372 124893.23432992074 130907.9793631141 130606.9419195939 134046.72124259418 139177.12357291149 0.9814259706855168 0.958154617103874 0.9487092284134553 0.8780165246774232 1.010422669075107 0.8973689865381665 0.9405854640653973 0.9384224832838431 0.9631376033746695 1.0 17.08656257053609 -8.605599808241491 3.0036281940064407 0.9999515108842396 0.9431711741993716 0.1870476684522564 0.035528663308678037 0.5839390405753088 12.63398518607836 0.03278612204078951 0.008730351411716578 2.479705993688545e-09 8.605599808241491 -0.05678033668486804 IIS(ph)PGSSTPSSTR ddPTM_A459_Selumetinib_30min_R2 1 IISPGSSTPSSTR 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 IIS(0.826)PGS(0.126)S(0.037)T(0.011)PSSTR 82.705 0.032505 29687000.0 54542.0 42282.0 47367.0 59279.0 64950.0 42196.0 51786.0 67184.0 54702.0 61570.0 True False 51510.77398892529 45524.89344194172 44319.45878929019 51205.097938021194 56790.40033963287 48008.1159828495 54194.15161201226 67379.49431709014 65643.9285015836 59792.3141219283 0.8614949052462609 0.7613837014086375 0.7412233401589724 0.8563826085339985 0.9497943201165632 0.8029144997624862 0.9063732087956944 1.126892231996408 1.0978656615919349 1.0 15.867672427671582 -7.617288579471059 4.083340923485039 1.0831798164616513 0.8299275285505564 0.7546145045088296 0.0625215030741015 0.11115288094037075 3.4424114838573483 0.033871084037413374 0.018622649192515637 2.41385634509032e-08 7.617288579471059 -0.2532522879110949 IIS(ph)SIEQK ddPTM_A459_Selumetinib_30min_R2 2 IISSIEQK 8 0 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 IIS(0.837)S(0.163)IEQK;IIS(0.913)S(0.087)IEQK 104.52 0.014543 3244400.0 27068.0 20806.0 26023.0 30007.0 28674.0 23734.0 30831.0 28853.0 25320.0 24308.0 True False 25563.668921789264 22401.753298165626 24348.70851170011 25919.994835037745 25071.715771187584 27003.143064199223 32264.70259046749 28936.957453128703 30384.70749991031 23606.16488023117 1.082923424939618 0.9489789388417698 1.0314554962754996 1.0980180375146105 1.0620833963666725 1.1439021628969825 1.3667913764970505 1.2258220511440117 1.2871513714350011 1.0 14.526876056114192 -6.913348368104497 3.314188013272212 1.2407913320423611 1.0407333886063364 0.41933729977528944 0.09550833339067186 0.2050380115015424 4.495240231714561 0.034594137794212124 0.029750329030881872 1.220819989955658e-07 6.913348368104497 -0.2000579434360248 IISIFSGT(ph)EK ddPTM_A459_Selumetinib_30min_R1 1 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 IISIFS(0.391)GT(0.609)EK 105.36 0.029372 6197900.0 1222.6 1600.7 1955.4 1890.9 1694.4 1506.5 1570.3 1279.3 1092.8 1224.9 True False 1251.0842012345224 1413.2892998547584 1689.8674202433563 1560.6898115890594 1541.141819170618 1491.3459777925568 1451.8510067442176 1245.368808247953 1854.4017850459072 1382.127846536378 0.9051870305411674 1.022545999197159 1.2226563732712394 1.1291935225096281 1.1150501185781982 1.07902172836607 1.0504462451737488 0.9010518175788556 1.3417006174161463 1.0 10.432675355549813 -4.918635233305402 4.078505996540093 1.1010533347657052 0.9109877583935005 0.2295336147173156 0.11293291593411418 0.3285631416329912 9.881997340457787 0.027559972541989407 0.13870677859305364 1.2060484828751109e-05 4.918635233305402 -0.19006557637220467 IISNASCT(ph)TNCLAPLAK ddPTM_A459_Selumetinib_30min_R2 1 IISNASCTTNCLAPLAK 17 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 IIS(0.069)NAS(0.039)CT(0.726)T(0.167)NCLAPLAK 132.5 0.0016416 57341000.0 86151.0 82812.0 84258.0 94614.0 104120.0 70689.0 78823.0 96813.0 64018.0 100780.0 True False 81363.07230977788 89163.41411745155 78836.93201317386 81727.4099817464 91039.51475538999 80425.76809914803 82488.42568481149 97094.709801745 76823.38881237205 97870.21954211348 0.8313363624852953 0.911037234151545 0.8055252392608601 0.8350590237163937 0.9302065038917763 0.8217593510612377 0.8428347874433528 0.9920761418131409 0.7849516346421906 1.0 16.578582315426246 -14.522878685838052 0.24709020408839164 1.800765999063471 0.852589201047772 0.3069944038568293 0.06116379249062384 217.50661737865644 2.156734225500153 87.8855016328961 0.08623588270241328 3.0000004106127924e-15 14.522878685838052 -0.948176798015699 IISNASCTT(ph)NCLAPLAK ddPTM_A459_Selumetinib_30min_R1 2 IISNASCTTNCLAPLAK 17 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 IIS(0.149)NASCT(0.152)T(0.699)NCLAPLAK;IIS(0.001)NASCT(0.044)T(0.955)NCLAPLAK 178.43 4.5779e-09 29919000.0 4918.5 7904.5 7249.6 8561.2 6936.299999999999 6025.6 6581.5 7716.299999999999 2887.3 5012.5 True False 5033.091480265008 6979.037465297647 6265.144139202323 7066.147133627508 6308.912889703231 5964.987934807058 6085.052156203954 7511.638657925184 4899.537219951543 5655.90320088464 0.8898828889924746 1.2339386332153026 1.1077177095644761 1.2493401818691472 1.1154563056730626 1.0546481654555322 1.0758762906784174 1.3281059436714349 0.8662696382754935 1.0 12.465541713720514 -6.531094036095431 23.464115409517934 1.086043692460482 1.134318179992869 0.02149990050538997 0.1410665916135011 445.04920278732624 1271109.8319695839 0.04466131041504545 0.04476218119641392 2.94378415864915e-07 6.531094036095431 0.048274487532387056 IISNASCTT(ph)NCLAPLAK ddPTM_A459_Selumetinib_30min_R2 1 IISNASCTTNCLAPLAK 17 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 IIS(0.368)NASCT(0.134)T(0.498)NCLAPLAK 208.52 1.0811e-08 15977000.0 75184.0 54075.0 60469.0 56797.0 60326.0 56147.0 51559.0 55741.0 44992.0 56108.0 True False 71005.57426539843 58222.3786214701 56578.49037366922 49061.15061971002 52747.30855871737 63880.739598280685 53956.59566222033 55903.19708158071 53991.65718151517 54488.016253908616 1.3031411151861296 1.0685354803551617 1.038365759362925 0.9004025837734676 0.9680533846730678 1.1723814517416624 0.9902470189185835 1.0259723316238472 0.990890491037874 1.0 15.733651347198242 -4.700099275994517 2.2956738549580202 1.0116650970002468 1.418246748106113 0.6454227966613306 0.06484718741942344 0.540873458991948 2.7967879602712564 0.017859540043110668 0.4852997367755022 1.9948062672392052e-05 4.700099275994517 0.4065816511058662 IISNASCTTNCLAPLAK ddPTM_A459_Selumetinib_30min_R1 2 IISNASCTTNCLAPLAK 17 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 238.17 2.5653e-21 257200000.0 5489.5 5071.8 6210.5 6588.9 5925.700000000001 4849.7 5385.7 5435.7 3354.0 4602.0 False True 5617.394669292416 4477.991298184146 5367.14821183459 5438.272303971204 5389.721481267307 4800.916421175288 4979.452312948056 5291.527578358007 5691.493033532187 5192.711527276032 1.0817844665134253 0.8623608830689637 1.0335926006369285 1.047289508651752 1.037939707021357 0.9245490329969726 0.9589310491815733 1.0190297594162354 1.096054152755488 1.0 12.342272365714958 -8.00192250038948 24.025673719352437 1.0511987093972863 0.9901083607574085 0.10528333400248169 0.06486578123901925 85.75428684797672 1071660.3782301003 0.03601858938670816 0.016831401451037276 9.955830627485773e-09 8.00192250038948 -0.061090348639877834 IISPGS(ph)STPSSTRSPPPGRDESYPR ddPTM_A459_Selumetinib_30min_R1 1 IISPGSSTPSSTRSPPPGRDESYPR 25 2 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 IIS(0.028)PGS(0.283)S(0.081)T(0.081)PS(0.094)S(0.094)T(0.094)RS(0.241)PPPGRDES(0.001)Y(0.001)PR 49.528 0.046127 19481000.0 824.11 721.6 1921.6 1865.5 1219.3 998.38 828.18 1112.1 720.61 574.49 True False 843.3101595610848 637.1147365372611 1660.6572745932447 1539.725444772008 1109.0145302848994 988.3372036565111 765.709715828457 1082.6034953900953 1222.822538727975 648.2313875064771 1.300940028228205 0.982850798058425 2.5618279315064045 2.3752713528649108 1.710831273614961 1.5246673066207177 1.1812290033870136 1.6700880522840744 1.8863982249174205 1.0 9.340365067733202 -6.7045250699526635 4.253161186281274 1.475270635775406 1.8250202809404237 0.10580967212569536 0.4852186986905975 0.5838495329159394 21.45691684066872 0.1827828301956372 0.17783808910918772 1.9745808920565745e-07 6.7045250699526635 0.3497496451650177 IISPGSST(ph)PSSTR ddPTM_A459_Selumetinib_30min_R2 1 IISPGSSTPSSTR 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 IIS(0.001)PGS(0.081)S(0.116)T(0.801)PS(0.001)STR 96.23 0.033686 0.0 51456.0 43187.0 38473.0 32360.0 35382.0 32719.0 47312.0 47811.0 31339.0 31225.0 True False 48596.281514688475 46499.30403190809 35997.68906623519 27952.51217588633 30936.99684090669 37225.74525649002 49512.10174694948 47950.12209446288 37607.67568482183 30323.453117706875 1.6025972149692769 1.5334435643398276 1.1871236737617767 0.9218116441878424 1.0202333065702713 1.2276222339187575 1.6327989281022124 1.5812883152962287 1.2402174494718563 1.0 14.888146430951815 -11.72696591937096 2.301116877154097 0.05064751305198492 1.3219332594355 0.14395008511184393 0.2392231601434435 3552436.065057584 912694.3321804975 17610505.862919778 0.0693306708603397 1.875141651313026e-12 11.72696591937096 1.271285746383515 IISPGSSTPSSTRS(ph)PPPGR ddPTM_A459_Selumetinib_30min_R1 1 IISPGSSTPSSTRSPPPGR 19 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 IISPGSSTPS(0.104)S(0.163)T(0.163)RS(0.568)PPPGR 66.939 0.01187 25864000.0 1680.2 2118.2 1524.2 2006.1 1681.6 1642.4 1728.7 1641.8 844.24 1777.6 True False 1719.3453908999209 1870.2001592755369 1317.2220118312985 1655.772294160881 1529.499576910593 1625.8789471798843 1598.302767215646 1598.2541306820049 1432.613619150034 2005.7722752902823 0.8571987020067326 0.9324090188677451 0.6567156342016272 0.825503629977761 0.7625489671748696 0.810599970499932 0.7968515603219883 0.7968273120390499 0.7142453990409761 1.0 10.969942103992599 -10.771294738948205 17.843728749283812 0.9999999980667978 0.7952987257492663 0.4281451806023092 0.0711544190204666 0.0 0.0 0.06824323726120475 0.016551416203649066 1.693188308701854e-11 10.771294738948205 -0.20470127231753155 IISPGSSTPSSTRS(ph)PPPGRDESYPR ddPTM_A459_Selumetinib_30min_R1 1 IISPGSSTPSSTRSPPPGRDESYPR 25 2 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 IIS(0.019)PGS(0.084)S(0.084)T(0.094)PS(0.106)S(0.106)T(0.106)RS(0.403)PPPGRDESYPR 70.501 0.0098704 0.0 847.62 947.73 1588.3 1660.0 1198.4 1074.6 838.57 1005.7 714.98 859.89 True False 867.3678968185875 836.7693310122766 1372.6175839073949 1370.1121620592512 1090.0049315947044 1063.7904996587333 775.3159897634195 979.0255690260037 1213.2688399269061 970.2652575378943 0.8939492474661878 0.8624129582209595 1.414682813018054 1.4121006100290474 1.1234092152909367 1.0963914160527244 0.7990763182955039 1.0090287799342 1.2504506685168217 1.0 9.922235404516893 -7.009880060718431 21.932027728186448 1.0057260198825948 1.1514332277430965 0.08213461188117421 0.19761119357661974 250.19816457089453 555398.639511254 0.07966876628188806 0.06619231718158634 9.775071422221976e-08 7.009880060718431 0.14570720786050173 IISSS(ph)PNKK ddPTM_A459_Selumetinib_30min_R1 1 IISSSPNKK 9 1 B9EGE7;Q8TCN5-2;Q8TCN5 B9EGE7 ZNF507 Zinc finger protein 507 1 IIS(0.007)S(0.056)S(0.937)PNKK 181.87 0.0026263 49133000.0 3018.6 3681.0 3734.8 3493.3 3048.3 3779.5 2766.9 3329.8 2934.1 2889.7 True False 3088.927506826869 3250.0268087495274 3227.634673787912 2883.2607323623993 2772.5818032210773 3741.4816615114337 2558.1905053560286 3241.482887285264 4978.953401814781 3260.6211430616154 0.9473432733514291 0.9967508232795975 0.9898833787102509 0.8842673238802324 0.8503231996519887 1.1474751273919257 0.7845715258271228 0.9941304877394063 1.5269953739978843 1.0 11.670931106374436 -8.032734735979746 22.422869509026043 1.2625202351449023 0.9446159359156697 0.41809591277792524 0.14931099725778924 162.70102809373057 111445.54359123122 0.09208667576562626 0.03490654753990966 9.273960974484681e-09 8.032734735979746 -0.3179042992292326 IISVT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 IISVTPVK 8 0 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 IIS(0.059)VT(0.941)PVK;IIS(0.012)VT(0.988)PVK 145.25 0.004721899999999999 181850000.0 14842.7 20770.5 14804.5 16832.4 14499.3 15835.199999999999 16670.0 15556.5 7391.5 14348.8 True False 15188.506031133355 18338.680204056513 12794.130215297519 13892.93732328081 13187.840875059328 15675.912265211216 15412.568478906005 15143.891085366447 12542.835646199504 16190.608249147832 0.9381059560830755 1.132673950345364 0.7902192442937355 0.858086188578619 0.814536469051646 0.9682102132287892 0.9519449943900176 0.9353503495561091 0.7746982357416793 1.0 13.982869565408933 -5.261795032761883 24.999997821586263 0.8859737616238516 1.0353899491372647 0.3268440103597978 0.085390638091678 34.00706032272452 2390696.7539957697 0.021787527739994962 0.05054579820988473 5.472741904741242e-06 5.261795032761883 0.14941618751341312 IISVT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 IISVTPVK 8 0 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 IIS(0.017)VT(0.983)PVK 128.03 0.010363 68625000.0 288300.0 235220.0 306880.0 303240.0 313870.0 276910.0 287330.0 272110.0 242260.0 260560.0 True False 272277.4401563411 253260.61764849245 287135.6749056802 261938.1888818219 274438.8445665987 315051.83896129654 300691.41433359374 272901.79504976416 290718.76930996316 253036.95578381783 1.0760382384182705 1.000883909877835 1.134757861816021 1.035177601115344 1.0845800911431513 1.2450823160805853 1.1883300342519514 1.0785056839006468 1.1489182218835212 1.0 17.9489885788524 -6.539671522655128 24.99223644885586 1.1432781696308012 1.0622482467407277 0.1844316959260044 0.06862644065684097 349.7841851139769 520570.7382874183 0.022166282499946077 0.022171634253737728 2.886213656939353e-07 6.539671522655128 -0.08102992289007349 IISVT(ph)PVKNIDPVK ddPTM_A459_Selumetinib_30min_R1 2 IISVTPVKNIDPVK 14 1 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 IIS(0.018)VT(0.982)PVKNIDPVK;IIS(0.044)VT(0.956)PVKNIDPVK 88.319 0.028987 84099000.0 5241.0 5816.9 11713.3 11610.3 8122.4 6969.200000000001 6443.9 6503.2 3343.6 4611.2 True False 5363.105102789245 5135.854643796559 10122.698196551348 9582.779057323203 7387.730354126189 6899.09617552731 5957.831434986345 6330.71401062932 5673.844993118129 5203.09243689162 1.030753377503556 0.9870773402720421 1.9455157330625379 1.8417468406630984 1.4198729781821238 1.325960716479006 1.1450558503906982 1.2167214185438058 1.0904755319910753 1.0 12.345153622778254 -7.084242832059123 2.2153225819418716 1.1234190183842099 1.4683305831334776 0.22972108618497833 0.2858086404709526 0.5566277271888106 5.3917309425130036 0.14342536104853426 0.10630857736207439 8.236774340130438e-08 7.084242832059123 0.34491156474926776 IIT(ph)LTGPTNAIFK ddPTM_A459_Selumetinib_30min_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 IIT(0.999)LT(0.001)GPTNAIFK 118.52 0.0079682 4194400.0 1385.2 1370.6 1712.8 1708.2 1712.1 1590.1 1690.5 1796.2 842.57 1420.9 True False 1417.4724648699985 1210.1295148253469 1480.2111677369423 1409.8949368853084 1557.2408572958047 1574.1050376952849 1562.984223970642 1748.5589411201229 1429.7797511220083 1603.286355738052 0.8841043646363993 0.754780648194489 0.9232356792904574 0.8793781172274006 0.971280552424429 0.9817990604496014 0.9748627987613245 1.0906092569565944 0.891780651662708 1.0 10.646816406416503 -5.992864616893237 1.0857061911193675 0.9961703761532954 0.8232971924946941 0.5280129971342452 0.058980730769959674 0.38145036370137364 0.9135324206500716 0.022308515376956006 0.046075605784293046 1.0165655386002269e-06 5.992864616893237 -0.17287318365860127 IIVDELKQEVIS(ph)TSSK ddPTM_A459_Selumetinib_30min_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6REE5;D6RAC2;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 IIVDELKQEVIS(0.545)T(0.247)S(0.153)S(0.054)K 64.374 0.032182 10648000.0 797.84 1268.3 1632.6 1703.9 1533.1 1657.6 1484.3 1197.1 761.87 1288.8 True False 816.4281196736061 1119.8068463833258 1410.9018872298777 1406.345851164312 1394.431375690789 1640.9260489803805 1372.3380559832133 1165.3490192711838 1292.837745216806 1454.2300339750875 0.5614160762736609 0.7700341900671468 0.9702054381129966 0.9670724839316613 0.958879505382762 1.12838135002271 0.9436870535756813 0.8013512250780178 0.8890187350091229 1.0 10.506039781310076 -4.928875488029821 2.2083672533925167 0.9570224673473037 0.5196167326098812 0.7177187334742376 0.0785056802448373 0.2686980865658834 1.9555104409977293 0.023433893193639484 0.20756295950519257 1.1779436408566286e-05 4.928875488029821 -0.4374057347374225 IIVDELKQEVISTS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6REE5;D6RAC2;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 IIVDELKQEVIS(0.046)T(0.2)S(0.554)S(0.2)K 81.788 0.011574 8706300.0 2165.8 2696.3 3354.5 3641.6 2467.3 2802.0 2377.7 2442.5 1403.1 1730.5 True False 2216.258926086805 2380.615942524138 2898.977324949544 3005.6629212981748 2244.133150637196 2773.8144240124425 2198.348174702748 2377.716965641857 2380.9582216305917 1952.6265314974303 1.1350142438079034 1.2191865183243675 1.4846552979726113 1.53929226752501 1.1492894900471393 1.4205555334154245 1.1258415980944798 1.217701863253099 1.2193618099640806 1.0 10.931200323656316 -8.470695943970181 0.590930302388415 1.0057916640566302 1.3295767394970912 0.3136405012076192 0.13664487169987447 1.098372861790573 0.9139034615070609 0.1498329129623498 0.06665028072073373 3.3830160330119967e-09 8.470695943970181 0.323785075440461 IIVEETKS(ph)NGQTVIEEK ddPTM_A459_Selumetinib_30min_R1 2 IIVEETKSNGQTVIEEK 17 1 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5 B1ALK7 ARHGEF7 Rho guanine nucleotide exchange factor 7 1 IIVEET(0.351)KS(0.642)NGQT(0.007)VIEEK;IIVEET(0.053)KS(0.89)NGQT(0.058)VIEEK 59.469 0.034945 15811800.0 4088.3999999999996 4917.2 4349.1 4567.6 4230.0 4216.2 3600.1 4253.700000000001 2884.5 4121.8 True False 4183.651765358434 4341.49193805574 3758.516107896276 3769.9544044709833 3847.3972468671545 4173.788856003307 3328.541558542863 4140.878058035114 4894.785824455454 4650.8731797319315 0.8995411407024375 0.9334788910124564 0.8081312825891569 0.8105906694897832 0.8272419174175186 0.8974204831454633 0.7156809979356854 0.8903442209692304 1.0524444841425629 1.0 12.183285885572488 -8.144908105585332 4.617574734757401 1.0239949980161207 0.8420304333583568 0.6001420868560339 0.05912822100416738 0.15312612840781334 4.966852178969449 0.044356816225374615 0.01563482955069761 7.162949584024674e-09 8.144908105585332 -0.1819645646577639 IIVEKPFGR ddPTM_A459_Selumetinib_30min_R2 2 IIVEKPFGR 9 1 P11413-3;P11413;P11413-2;E7EUI8;E9PD92;E7EM57 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 ; 148.99 0.0041541 22753000.0 123612.0 96175.0 132923.0 139646.0 141737.0 104011.0 91294.0 111807.0 92335.0 122736.0 False True 116742.13989804238 103551.31324863424 124370.87889561981 120625.97389721328 123930.73091514317 118337.57113214902 95539.351895629 112132.33985935478 110804.58005545878 119192.29277357487 0.9794436970837792 0.8687752440952435 1.043447323661124 1.0120283039303717 1.039754568280432 0.992829052772317 0.8015564569860363 0.9407683773007738 0.9296287325049623 1.0 16.86293142553194 IIYGGS(ph)VTGATCK ddPTM_A459_Selumetinib_30min_R1 1 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 1 IIYGGS(0.992)VT(0.008)GATCK 175.29 0.0001012 21846000.0 1433.3 1456.8 1877.2 1875.9 1946.1 1901.4 1854.9 2076.9 977.95 1239.1 True False 1466.6931012836903 1286.2371787520538 1622.2865507215033 1548.3092800041873 1770.075598611862 1882.2736423330693 1714.9833996114423 2021.813865278022 1659.5097233580207 1398.1505548560904 1.0490237236537483 0.919956133682931 1.1603089131473991 1.1073981086132405 1.2660121561758801 1.3462596254713135 1.226608532003167 1.4460630568402015 1.186932063642339 1.0 10.449304005210475 -5.777489265163814 1.3396913940589914 1.271326239944167 0.9873863205378145 0.376217687235637 0.11979210933868707 0.40126660024009686 1.4397291429391161 0.03878012161520932 0.09330339422539023 1.6692090660001439e-06 5.777489265163814 -0.28393991940635244 IIYGGS(ph)VTGATCK ddPTM_A459_Selumetinib_30min_R2 2 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 1 IIY(0.003)GGS(0.929)VT(0.067)GATCK;IIY(0.001)GGS(0.623)VT(0.362)GAT(0.014)CK 124.47 0.0022534000000000005 30853000.0 138870.0 149952.0 174065.0 171152.0 160465.0 128331.0 116712.0 124180.0 114589.0 148075.0 True False 131152.16134065576 161452.836228325 162865.84740764252 147840.80234633188 140305.95212469884 146007.43037716992 122139.3392604405 124541.34324089436 137510.00188417174 143799.69000494652 0.9120475943734253 1.1227620603547284 1.1325883067066427 1.0281023717175353 0.9757041348272205 1.0153528868674715 0.8493713669079472 0.8660751858130592 0.9562607671785772 1.0 17.13370104013886 -6.71862172366707 1.5005332540464729 0.9118706023258231 1.0586151202572471 0.34628679134851514 0.0734515883226392 0.39000732386826775 1.8273134534571405 0.03272683097794102 0.03074608273415682 1.9115174911121247e-07 6.71862172366707 0.14674451793142407 IIYGGSVTGATCK ddPTM_A459_Selumetinib_30min_R1 1 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 148.28 0.007626600000000002 9666000.0 1412.9 1525.1 1700.6 1342.4 1578.7 1716.6 1796.0 1602.5 1076.3 1410.8 False True 1445.8178209751816 1346.5405830002446 1469.6678607271408 1107.9750399688783 1435.9068637421235 1699.3325625480943 1660.5262740321036 1559.9964943463967 1826.402490158227 1591.8899223557198 0.9082398227860021 0.8458754365424961 0.9232220394688399 0.6960123463369051 0.9020139166514928 1.0674937624037333 1.0431162674708148 0.97996505439137 1.1473170754517181 1.0 10.636524863029758 -6.650058042057386 4.612845314131203 1.0456180631588363 0.8439627746560964 0.6543147369547818 0.07077538299732238 0.13262421505373823 4.77090980442194 0.02344270551183671 0.0232826588253536 2.238421960698101e-07 6.650058042057386 -0.20165528850273995 IIYGGSVTGATCK ddPTM_A459_Selumetinib_30min_R2 2 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 ; 199.03 0.0019422 12499200.0 51828.0 52676.0 52853.0 55857.0 56072.0 41190.0 40335.0 46636.0 36807.0 45537.0 False True 48947.60724392245 56716.079819964085 49452.49552199539 48249.18024130047 49027.734069959864 46863.5486144083 42210.65742228626 46771.7030389946 44169.42847350708 44222.2284906651 1.1068552832938945 1.2825242362432352 1.1182723532902543 1.0910617100964377 1.108667196188658 1.0597283360403413 0.9545122184694184 1.0576514263379484 0.9988060299320022 1.0 15.432484108263568 -6.234558647454105 0.7971989657692313 1.0042863821274588 1.1960393746827247 0.6233766635998205 0.05270227197473175 0.44044821331465106 0.599456148821139 0.028315811147167202 0.05026322455292192 5.826950819001558e-07 6.234558647454105 0.1917529925552659 IKDNGDLVLS(ph)SPSNVTLPQVK ddPTM_A459_Selumetinib_30min_R1 1 IKDNGDLVLSSPSNVTLPQVK 21 1 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;P04150-12;P04150-13;P04150-11 P04150-3 NR3C1 Glucocorticoid receptor 1 IKDNGDLVLS(0.416)S(0.416)PS(0.167)NVTLPQVK 111.84 5.4297e-05 32696000.0 4125.7 4455.8 5061.5 4950.7 4379.2 4205.9 4717.0 4489.2 2200.4 3457.1 True False 4221.820782785268 3934.112864554778 4374.176100829368 4086.1531811486366 3983.102133210554 4163.592464651656 4361.192892321514 4370.131833023302 3733.9180891425813 3900.8524600056435 1.0822815848767477 1.0085264451527312 1.1213385139983068 1.0475026223223847 1.0210850510364577 1.067354509646241 1.118010213673963 1.1203017488687534 0.9572056691262759 1.0 11.92957371772246 -8.272038980343217 24.99677663936892 0.9786028220070209 1.0714339812033802 0.4857089050353983 0.03893962362594902 710.0166530397289 1674395.3547718565 0.037183960580149465 0.010028714978892152 5.345163814282061e-09 8.272038980343217 0.09283115919635931 IKDNGDLVLSS(ph)PSNVTLPQVK ddPTM_A459_Selumetinib_30min_R2 1 IKDNGDLVLSSPSNVTLPQVK 21 1 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;P04150-12;P04150-13;P04150-11 P04150-3 NR3C1 Glucocorticoid receptor 1 IKDNGDLVLS(0.424)S(0.531)PS(0.043)NVT(0.002)LPQVK 109.22 6.5086e-05 7078400.0 56163.0 50098.0 63269.0 63938.0 61538.0 49448.0 54576.0 50017.0 40368.0 49808.0 True False 53041.68529830244 53940.35550954059 59198.34142207868 55229.53410079792 53807.04628329987 56259.01315574798 57113.89214029241 50162.541189239906 48442.727976160306 48369.913623274384 1.0965842467988223 1.1151633622844812 1.2238670071470612 1.1418158512944472 1.1124073262229122 1.1630993099122997 1.1807730852099485 1.0370607973362795 1.0015053645423688 1.0 15.561822341038312 -7.872291795577337 4.8599485078148845 1.0067404633064478 1.1481423771259036 0.7583237131927968 0.03515346061770074 0.10613232264998432 4.019134537201998 0.02121486584764425 0.00984138889301745 1.3418630816610841e-08 7.872291795577337 0.14140191381945577 IKDNGDLVLSSPSNVT(ph)LPQVK ddPTM_A459_Selumetinib_30min_R2 1 IKDNGDLVLSSPSNVTLPQVK 21 1 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;P04150-12;P04150-13;P04150-11 P04150-3 NR3C1 Glucocorticoid receptor 1 IKDNGDLVLS(0.219)S(0.219)PS(0.207)NVT(0.354)LPQVK 65.78399999999999 0.013577 8082400.0 23004.0 20026.0 25526.0 28556.0 27344.0 22121.0 20250.0 20475.0 18687.0 23403.0 True False 21725.529772308273 21561.92980626095 23883.68495060741 24666.62353815236 23908.802261538447 25167.966955555352 21191.66512461376 20534.578860181286 22424.922158405363 22727.294581703558 0.9559223907714142 0.948723999187269 1.050881127304734 1.0853303920304727 1.0519862879229829 1.1073894811842955 0.9324323688607422 0.9035206010271235 0.9866956261682982 1.0 14.472138337974485 -10.221515157062633 5.446698972707063 0.999999999572379 1.0043797376733419 0.0 0.06534536814670058 3.103864043512376e-10 9.708080895910023e-11 0.0709702875286815 0.017212821634076253 6.004610521950473e-11 10.221515157062633 0.004379738100962927 IKDPDASKPEDWDER ddPTM_A459_Selumetinib_30min_R2 1 IKDPDASKPEDWDER 15 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 120.21 0.00733 5266600.0 47591.0 43184.0 40271.0 40967.0 41234.0 33628.0 44066.0 39174.0 27609.0 41220.0 False True 44946.082741867634 46496.07394155458 37680.00770374954 35387.22392798321 36053.81628336293 38259.95175540962 46115.1563151225 39287.9898543952 33131.57145991407 40029.87149757814 1.1228135654791431 1.1615344292166327 0.9412972436353995 0.8840204228515742 0.9006727959529981 0.9557850256332797 1.152018594861403 0.9814667992819356 0.8276711920476331 1.0 15.288789363995752 -5.262081432262678 24.992570099573847 0.9572414203385118 1.1421740104911788 0.4555081686467386 0.0816756236213963 51.48469059243029 2004188.981312263 0.02287050841253214 0.052663478643918966 5.469134044376211e-06 5.262081432262678 0.18493259015266705 IKEEEPDPEEWQLS(ph)GDSTLNTNDLTHLR ddPTM_A459_Selumetinib_30min_R1 1 IKEEEPDPEEWQLSGDSTLNTNDLTHLR 28 1 A0A494C1G8;A0A494C0Z6;H0Y6K5;A0A494C070;H0Y7L6;Q02447-4;Q02447-3;Q02447-5;Q02447-6;Q02447-2;Q02447 A0A494C1G8 SP3 Transcription factor Sp3 1 IKEEEPDPEEWQLS(0.99)GDS(0.008)T(0.002)LNTNDLTHLR 102.58 1.2665e-07 4792100.0 1490.5 2124.2 1672.4 2260.6 2110.3 1742.3 1981.2 1888.3 1157.7 1386.2 True False 1525.2257499918658 1875.4976764862126 1445.2972658356284 1865.828646717555 1919.423737603726 1724.7740438818275 1831.7564889267298 1838.2161499371618 1964.5323449374503 1564.1322727314296 0.9751258103819943 1.1990659033018023 0.9240249632543668 1.1928841820131209 1.2271492450263521 1.1027034439164602 1.1711007571808174 1.1752306259413101 1.2559886265288842 1.0 10.611146805711828 -5.804811533856429 24.999652064797495 1.168806522349303 1.0493708469894747 0.2730983229067373 0.09387689936113223 172.14102047680075 99221.04282629266 0.02479010627916223 0.03676990180767558 1.5674311239042453e-06 5.804811533856429 -0.11943567535982824 IKEEPVS(ph)EEGEEDEEQEAEEEPMDTSPSGLHSK ddPTM_A459_Selumetinib_30min_R1 1 IKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSK 33 1 A0A0C4DH01;Q9NVU0-3;Q9NVU0-2;Q9NVU0-5;Q9NVU0-4;Q9NVU0 A0A0C4DH01 POLR3E DNA-directed RNA polymerase III subunit RPC5 1 IKEEPVS(0.998)EEGEEDEEQEAEEEPMDT(0.001)S(0.001)PSGLHSK 63.203 0.00013248 8230500.0 1181.2 1148.3 1449.0 1389.7 1557.5 1218.2 1875.1 1277.4 402.35 716.17 True False 1208.7196617848983 1013.8565021698129 1252.2337587872673 1147.0149828998444 1416.6243999989586 1205.9460140371011 1733.6596973483292 1243.5192024200228 682.7585635186866 808.0973955865442 1.4957598779384373 1.2546216677680564 1.54960746764733 1.4194019052212172 1.7530367103469318 1.4923275593058745 2.1453598375849 1.5388234255073114 0.8448963791339998 1.0 9.658385373422327 -8.241333628874699 8.529603859914431 0.9219268017117508 1.585832863374013 0.5760827756827102 0.22599540955995467 0.1635049788664918 64.98441949134663 0.16983181069092193 0.060503196883243085 5.736755902092243e-09 8.241333628874699 0.6639060616622623 IKEEPVS(ph)EEGEEDEEQEAEEEPMDTSPSGLHSK ddPTM_A459_Selumetinib_30min_R2 2 IKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSK 33 1 A0A0C4DH01;Q9NVU0-3;Q9NVU0-2;Q9NVU0-5;Q9NVU0-4;Q9NVU0 A0A0C4DH01 POLR3E DNA-directed RNA polymerase III subunit RPC5 1 IKEEPVS(1)EEGEEDEEQEAEEEPMDTSPSGLHSK;IKEEPVS(1)EEGEEDEEQEAEEEPMDTSPSGLHSK 78.257 3.452e-06 33797000.0 54917.0 50939.0 76511.0 97065.0 98872.0 63568.0 57763.0 65245.0 64670.0 83503.0 True False 51864.9329901692 54845.85750529938 71588.3655588781 83844.5795535355 86450.81543310525 72323.9149871499 60449.0939552131 65434.85214810882 77605.8070307741 81092.05142315048 0.6395809710070128 0.6763407330652602 0.8828037310996028 1.033943254389039 1.066082481771141 0.8918742801283058 0.7454379670305868 0.8069206660793418 0.9570088025744393 1.0 16.307272889128917 -5.268960059690855 3.899892448535344 0.9198356767303346 0.6491556059204227 0.5685629486821802 0.0930140681803946 0.17479856440497643 6.178351825341507 0.02816494032905018 0.07312562483297755 5.383192872901594e-06 5.268960059690855 -0.27068007080991197 IKEEVLS(ph)ESEAENQQAGAAALAPEIVIK ddPTM_A459_Selumetinib_30min_R1 2 IKEEVLSESEAENQQAGAAALAPEIVIK 28 1 Q9UJX5;Q9UJX5-3 Q9UJX5 ANAPC4 Anaphase-promoting complex subunit 4 1 IKEEVLS(0.713)ES(0.287)EAENQQAGAAALAPEIVIK;IKEEVLS(0.883)ES(0.117)EAENQQAGAAALAPEIVIK 112.54 1.585e-10 209680000.0 6626.7 7423.700000000001 8554.5 8785.8 8272.7 7201.6 7663.4 7561.3 3588.7 5650.0 True False 6781.089216686414 6554.5297528155015 7392.845886504951 7251.524959891668 7524.435745663817 7129.158442529629 7085.34356816126 7360.749761436137 6089.76179172241 6375.232535660495 1.0636614709747008 1.0281240278142154 1.1596198013409447 1.1374526214266765 1.1802605949783227 1.118258573730758 1.1113859029500004 1.1545852986950758 0.9552219087944986 1.0 12.638262249680782 -8.264465937649625 24.999322948137277 0.9776109373838732 1.1198382143953178 0.6230563179573395 0.04403960109283108 189.68556862975032 1566754.9482985171 0.03975628266887202 0.011936499913510607 5.43918790392459e-09 8.264465937649625 0.14222727701144466 IKEEVLS(ph)ESEAENQQAGAAALAPEIVIK ddPTM_A459_Selumetinib_30min_R2 2 IKEEVLSESEAENQQAGAAALAPEIVIK 28 1 Q9UJX5;Q9UJX5-3 Q9UJX5 ANAPC4 Anaphase-promoting complex subunit 4 1 IKEEVLS(0.67)ES(0.33)EAENQQAGAAALAPEIVIK;IKEEVLS(0.512)ES(0.488)EAENQQAGAAALAPEIVIK 73.892 7.345e-05 19395300.0 102603.5 93060.1 101407.8 105385.5 118672.4 77714.4 85849.0 87052.1 71109.3 106802.2 True False 96901.20822435367 100197.510434616 94883.33255246459 91031.81309987238 103763.71216728337 88418.85317891651 89841.14860656635 87305.40719874908 85333.14695984882 103718.54298055884 0.9342708202381611 0.966052043879918 0.91481551732027 0.8776811791208398 1.00043549769816 0.852488384796245 0.8662014141811297 0.8417531204146759 0.8227376176682678 1.0 16.662314319162498 -6.794502355548745 24.998424279943503 0.8660934726667713 0.9354619499587709 0.23385357481782054 0.05432485017744074 245.6626659817651 185740.20957540657 0.018249752722857684 0.016095822488747413 1.605083552338568e-07 6.794502355548745 0.06936847729199958 IKEEVLSES(ph)EAENQQAGAAALAPEIVIK ddPTM_A459_Selumetinib_30min_R2 1 IKEEVLSESEAENQQAGAAALAPEIVIK 28 1 Q9UJX5;Q9UJX5-3 Q9UJX5 ANAPC4 Anaphase-promoting complex subunit 4 1 IKEEVLS(0.452)ES(0.548)EAENQQAGAAALAPEIVIK 44.319 0.031156 15845000.0 13533.0 14150.0 14348.0 14901.0 13671.0 9721.9 11421.0 12634.0 10594.0 11675.0 True False 12780.890036891313 15235.259500578866 13424.865300921227 12871.458094341246 11953.526759709333 11061.00347837863 11952.099130282162 12670.762848328712 12713.09602109202 11337.91241470705 1.1272701331077928 1.3437446809711058 1.1840685313027353 1.1352582048212814 1.054296974829664 0.9755767264554606 1.0541710584021107 1.1175569527149236 1.1212907240843686 1.0 13.46886740905352 -5.877186579927359 2.218582151466739 1.0567396138851721 1.2378424639145598 0.5622733066595975 0.06536730264706919 0.21947230521853223 2.1987121848779476 0.020347300280018733 0.034905570215786455 1.3268243101019034e-06 5.877186579927359 0.18110285002938764 IKGS(ph)SPGIQDTLEAEDGAFETDEAPEDR ddPTM_A459_Selumetinib_30min_R1 2 IKGSSPGIQDTLEAEDGAFETDEAPEDR 28 1 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 1 IKGS(0.5)S(0.5)PGIQDTLEAEDGAFETDEAPEDR;IKGS(0.5)S(0.5)PGIQDTLEAEDGAFETDEAPEDR 147.22 2.7931e-14 86831000.0 4545.200000000001 5485.0 6773.700000000001 7947.4 5514.7 5369.6 5148.5 5657.200000000001 2717.3 4540.0 True False 4651.094316580361 4842.813650092679 5853.868745270747 6559.535781174511 5015.8963586993605 5315.586699206714 4760.144499918872 5507.152678824611 4611.059636260291 5122.753223344892 0.9079286301328874 0.9453536875490117 1.1427192546761944 1.2804707732713063 0.9791407354626075 1.0376425463914718 0.9292160469933284 1.075037667972756 0.9001135591008439 1.0 12.322703679669146 IKGS(ph)SPGIQDTLEAEDGAFETDEAPEDR ddPTM_A459_Selumetinib_30min_R2 6 IKGSSPGIQDTLEAEDGAFETDEAPEDR 28 1 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 1 IKGS(0.586)S(0.413)PGIQDTLEAEDGAFETDEAPEDR;IKGS(0.491)S(0.491)PGIQDT(0.018)LEAEDGAFETDEAPEDR;IKGS(0.5)S(0.5)PGIQDTLEAEDGAFETDEAPEDR;IKGS(0.491)S(0.491)PGIQDT(0.018)LEAEDGAFETDEAPEDR;IKGS(0.781)S(0.218)PGIQDT(0.001)LEAEDGAFETDEAPEDR;IKGS(0.497)S(0.497)PGIQDT(0.006)LEAEDGAFETDEAPEDR 129.4 1.7452e-12 37074400.0 130720.0 111741.0 135292.0 152937.0 142812.0 107355.0 110199.0 119469.0 92199.6 125425.0 True False 123455.10571362101 120311.17539605507 126587.46001479204 132106.71676895948 124870.67980452102 122142.17677833956 115323.47185517583 119816.63501084226 110642.09627206663 121803.65435671352 1.0135583071429948 0.9877468457860256 1.039274730165884 1.0845874655129186 1.025180077428756 1.00277924684127 0.946798127398051 0.9836867017137919 0.908364341418204 1.0 16.894197892108153 -7.040955274381441 2.887372128451195 0.9582973154121125 1.0310632531336912 0.516894478328346 0.03197303467690171 0.22741704827617937 3.7842166431817574 0.013541890940989005 0.010632924558817987 9.100069844597621e-08 7.040955274381441 0.07276593772157869 IKNENTEGS(ph)PQEDGVELEGLK ddPTM_A459_Selumetinib_30min_R1 7 IKNENTEGSPQEDGVELEGLK 21 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK 154.45 2.4415e-07 820385800.0 43881.399999999994 59524.6 62572.5 67411.9 49672.1 52396.9 51645.9 49153.2 22068.13 38573.1 True False 44903.7512416592 52555.4321597642 54075.498186139615 55639.67714308554 45179.26732532152 51869.83475857874 47750.208182647344 47849.49746390473 37448.004817555935 43524.33311881166 1.031693032931304 1.2074954030036409 1.2424199134430307 1.2783579472935682 1.038023195025005 1.1917433546192595 1.0970922415353268 1.0993734776656163 0.8603923859173509 1.0 15.409534572576797 -8.023059416730446 2.472758598746852 0.9326527943837335 1.1637496401382823 0.5137074249170519 0.08477214831466964 0.23686903502724602 2.701216339321206 0.06845888736437754 0.023280188889463847 9.48288717075938e-09 8.023059416730446 0.2310968457545488 IKNENTEGS(ph)PQEDGVELEGLK ddPTM_A459_Selumetinib_30min_R2 7 IKNENTEGSPQEDGVELEGLK 21 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENT(0.008)EGS(0.992)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENT(0.003)EGS(0.997)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK;IKNENTEGS(1)PQEDGVELEGLK 116.85 4.1941e-05 448862300.0 632525.2 593813.0 690557.0 657510.0 634535.7 513045.7 540000.0 662293.5 443126.9 651900.0 True False 597371.9815829961 639356.5476902627 646127.3144416137 567956.0037319848 554819.6525448684 583713.0882098357 565111.0699897001 664220.6644364091 531764.662000078 633077.9531603885 0.9435994076256413 1.0099175693902003 1.0206125662978494 0.8971343906333992 0.8763844164453258 0.9220240340006811 0.8926405779392713 1.0491925380129778 0.839967115179822 1.0 19.2720236292463 -5.761775730703757 24.999993208534573 0.9238446145247263 0.9932306231187886 0.20244580261404788 0.059984650640627385 13.447581988435308 999672.5008661988 0.016134331921600135 0.025715709730505597 1.730709865575597e-06 5.761775730703757 0.0693860085940623 IKPNLSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IKPNLSSSPR 10 1 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 IKPNLS(0.001)S(0.036)S(0.963)PR 68.847 0.043279000000000005 44148000.0 145070.0 167170.0 166070.0 157730.0 160540.0 120300.0 122750.0 133560.0 137440.0 159470.0 True False 137007.59016122235 179991.4014637289 155385.2370033444 136246.90190057323 140371.52995419025 136870.2330253295 128458.11822451054 133948.63748795158 164931.84039445792 154865.68674718073 0.8846865502549196 1.162241973960094 1.0033548442335831 0.8797746276939785 0.9064082102534935 0.8837996066150604 0.8294808289858249 0.8649342556212831 1.0649992510200808 1.0 17.240657999174545 -5.645374440358466 5.287899659052728 0.9075602852217498 1.0368301806064366 0.18998954622174347 0.09036800975166273 0.2616922650701608 10.993378076155132 0.02394943952813594 0.04215429561058663 2.262692616256551e-06 5.645374440358466 0.1292698953846868 IKPVTENLVLSSHTGFCQS(ph)SGDEALSK ddPTM_A459_Selumetinib_30min_R1 1 IKPVTENLVLSSHTGFCQSSGDEALSK 27 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LP59 P46100-4 ATRX Transcriptional regulator ATRX 1 IKPVTENLVLSSHTGFCQS(0.94)S(0.06)GDEALSK 98.446 7.5197e-07 18842000.0 3300.9 4754.0 2905.7 3471.0 5641.7 3840.9 5560.5 4182.2 1001.0 2576.1 True False 3377.8045475666886 4197.399469925361 2511.1218998676063 2864.8550087395533 5131.409231123036 3802.2640332581695 5141.067008215764 4071.274470299844 1698.623889852628 2906.7675283389385 1.162048397278238 1.4440093433697978 0.8638881077987608 0.9855810555227524 1.7653318268817186 1.3080729697813018 1.7686543413238167 1.400619220700583 0.5843686752697765 1.0 11.505199979760727 -8.251680121900382 24.64454257654357 0.7921843323534856 1.341005132365201 0.3584804977384515 0.29164232441019133 562.3044645706665 1419968.5512504156 0.2124908851047567 0.07803855445146958 5.601700408935938e-09 8.251680121900382 0.5488208000117154 IKQHLENDPGS(ph)NEDTDIPK ddPTM_A459_Selumetinib_30min_R2 2 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 IKQHLENDPGS(0.775)NEDT(0.225)DIPK;IKQHLENDPGS(0.851)NEDT(0.149)DIPK 79.332 0.0038377 7965000.0 97994.0 110944.0 112666.0 111695.0 106495.0 75040.0 66269.0 67322.0 45802.0 91758.0 True False 92547.88578106303 119453.04805881434 105417.19222146583 96481.94831537793 93116.14602262051 85376.07885470246 69350.63980953232 67517.89587424287 54963.679814806135 89108.7081240846 1.0385953037517877 1.340531700812843 1.183017849104843 1.0827443282089337 1.0449724609737976 0.958111509548714 0.7782700621465749 0.7577025556270398 0.6168160325954761 1.0 16.443278805163608 -6.774880316958705 1.146567494093269 0.7576904781506678 1.1909175844243958 0.677032260219012 0.11539526831630303 0.25298063465354426 0.704237354195328 0.058808306198303864 0.05237291848765832 1.679266727337049e-07 6.774880316958705 0.43322710627372796 IKQS(ph)SQDNELK ddPTM_A459_Selumetinib_30min_R1 1 IKQSSQDNELK 11 1 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 IKQS(0.918)S(0.082)QDNELK 174.21 0.00068945 11516000.0 1824.7 1979.1 2627.0 2437.1 2172.1 2078.0 1896.7 2032.8 1327.2 1723.4 True False 1867.2119597518677 1747.3860519413709 2270.2678290780896 2011.5062350328922 1975.6339385154026 2057.09720667304 1753.630391958069 1978.8835405350117 2252.161465147261 1944.6151773375743 0.960196125954503 0.8985767838826418 1.167463802368536 1.0343980950446454 1.0159511051540269 1.0578428218839 0.9017878767967923 1.01762218232008 1.1581527756204992 1.0 10.925268971145568 -5.211397850759536 24.9999650197833 1.0388308461645077 0.9293863753507862 0.27732488373419717 0.07370595086062098 508.75781042798434 254165.68509004454 0.018968646701788508 0.05018620053215799 6.146135763172282e-06 5.211397850759536 -0.10944447081372155 IKQS(ph)SQDNELK ddPTM_A459_Selumetinib_30min_R2 1 IKQSSQDNELK 11 1 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 IKQS(0.973)S(0.027)QDNELK 67.234 0.041459 5628900.0 97090.0 89222.0 81240.0 71860.0 74841.0 63905.0 73852.0 71731.0 44910.0 76731.0 True False 91694.12648206434 96065.04050605294 76013.10684742391 62072.54403458569 65438.804492970994 72707.33367816845 77286.26433496173 71939.72533429369 53893.25489024379 74515.57665891966 1.2305363602267496 1.2891940828126676 1.0200968744475924 0.8330143416685951 0.8781896004442695 0.9757333558723154 1.0371826643538484 0.9654320419955089 0.7232481758401942 1.0 16.185254416125765 -5.388993817689135 3.7387579525136108 0.9207358703266931 1.2598855799381308 0.7050468434960269 0.0874771597207482 0.12671912641986627 3.105871417746671 0.024265803359821415 0.05532531725899294 4.08325198921733e-06 5.388993817689135 0.33914970961143764 IKQSS(ph)QDNELK ddPTM_A459_Selumetinib_30min_R1 1 IKQSSQDNELK 11 1 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 IKQS(0.331)S(0.669)QDNELK 161.48 0.00046904 0.0 2562.9 2546.7 3041.0 3300.1 2286.9 2313.9 2025.5 2282.2 1377.2 1925.9 True False 2622.610583464712 2248.5311800712902 2628.0489030173085 2723.7994855492375 2080.050298784988 2290.6242668531036 1872.7149042605936 2221.668642369639 2337.0078132917483 2173.108024854609 1.2068477744635713 1.0347075038856972 1.209350328174844 1.2534119125216852 0.9571775885021423 1.0540774966796034 0.8617679760240574 1.0223461590310399 1.0754218320316151 1.0 11.08554417710508 -6.271542344383463 24.983091727850375 0.992528234364222 1.168357886195474 0.5735853917385816 0.07629612362538096 530.396509052944 1311587.36703355 0.024082104696793876 0.027609882026474585 5.351279754226096e-07 6.271542344383463 0.175829651831252 IKQTLPSS(ph)PTTTK ddPTM_A459_Selumetinib_30min_R1 1 IKQTLPSSPTTTK 13 1 F8VW64;F8VWX1;F8W659;J3KQU3;P51513-2;P51513 F8VW64 NOVA1 RNA-binding protein Nova-1 1 IKQTLPS(0.27)S(0.531)PT(0.13)T(0.064)T(0.004)K 121.18 0.0091184 0.0 960.02 921.81 1390.8 1690.4 1552.5 1289.2 1037.0 1222.0 721.61 827.81 True False 982.38659812626 813.884056662157 1201.936999117551 1395.2033727379273 1412.0766491161373 1276.2318184999442 958.7782551065103 1189.5885903845854 1224.519465690865 934.0674770522323 1.051729797109 0.8713332565979548 1.2867774851884064 1.493685849271796 1.5117501506127005 1.3663165133717403 1.0264550245687403 1.2735574459125125 1.3109539682885145 1.0 9.867382963791359 -5.273636942260284 22.935347950902788 1.3028662793642054 0.9615315522857798 0.37690357949101705 0.1642121835422132 221.6075726629203 416695.82975205156 0.04504103415058939 0.09513763365176306 5.325532725042212e-06 5.273636942260284 -0.3413347270784256 IKS(ph)PESVPVDSNK ddPTM_A459_Selumetinib_30min_R2 1 IKSPESVPVDSNK 13 1 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 IKS(0.991)PES(0.009)VPVDSNK 110.6 0.003046 5521700.0 70735.0 56964.0 51477.0 62232.0 56259.0 51463.0 64093.0 59835.0 49667.0 63763.0 True False 66803.83187464032 61332.95563187093 48165.02586391986 53755.89424381212 49191.24145815865 58551.561115399236 67073.4514978701 60009.10994378247 59601.78781192916 61921.996513830054 1.0788384683255479 0.9904873725796686 0.7778338647908805 0.8681227555672553 0.7944065796904975 0.9455696587935751 1.0831926500123343 0.9691081250970267 0.9625301373901489 1.0 15.918164367733425 -7.0023145834705 24.976188834131197 1.003025947563726 0.8952743652486245 0.22912127255799675 0.08757355410486536 141.24187515730787 1524127.7341141214 0.03356951669318698 0.02913380932640204 9.946846513285567e-08 7.0023145834705 -0.10775158231510151 IKTEPS(ph)SPLSDPSDIIR ddPTM_A459_Selumetinib_30min_R2 1 IKTEPSSPLSDPSDIIR 17 1 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 IKTEPS(0.495)S(0.495)PLS(0.009)DPS(0.001)DIIR 119.51 0.0071336 4129400.0 8729.8 9901.0 10729.0 9552.1 9067.8 6681.5 5103.8 7957.5 4608.6 12594.0 True False 8244.632664158258 10660.374863267223 10038.70782085195 8251.08750170841 7928.621896839457 7601.81597638186 5341.1368129878365 7980.655007564958 5530.44877504292 12230.378496858295 0.6741109987950181 0.8716308220555586 0.8208010752431468 0.674638769669142 0.6482728150135451 0.6215519804505308 0.43671067206626946 0.6525272304217736 0.45218950308558037 1.0 13.578181431582443 -6.009818675562624 2.282797619884514 0.6053405723990379 0.7969191292127245 0.14866123789515573 0.1530093871286271 0.44185573656322946 4.612811852797187 0.0455025347493135 0.06977703594378279 9.776453172890652e-07 6.009818675562624 0.19157855681368652 IKTEPSS(ph)PLSDPSDIIR ddPTM_A459_Selumetinib_30min_R2 1 IKTEPSSPLSDPSDIIR 17 1 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 IKT(0.006)EPS(0.17)S(0.78)PLS(0.037)DPS(0.006)DIIR 161.35 0.00010183 4099400.0 12415.0 16822.0 14362.0 14719.0 14586.0 10638.0 7696.2 8850.6 8209.0 16019.0 True False 11725.024001182717 18112.193308744714 13437.96455616327 12714.246808308751 12753.576279505536 12103.287937850826 8054.088549730981 8876.353780704294 9851.029378624164 15556.489847639592 0.7537062741028158 1.1642853552527406 0.8638172677625108 0.8172953495828561 0.8198235208851214 0.7780217810309743 0.5177317395256128 0.5705884725692869 0.6332424264795746 1.0 13.925228948184138 -6.42136411848969 1.1730211398281116 0.6538691369036984 0.9454480920607276 0.26108967372515757 0.1583958390681143 0.5159330377997865 1.4812875336407365 0.06823906838967254 0.08559555936110501 3.789970953334423e-07 6.42136411848969 0.29157895515702914 IKTGSPGS(ph)EVVTLQQFLEESNK ddPTM_A459_Selumetinib_30min_R1 1 IKTGSPGSEVVTLQQFLEESNK 22 1 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 IKT(0.231)GS(0.319)PGS(0.446)EVVT(0.004)LQQFLEESNK 61.238 0.007393300000000002 13583000.0 1270.4 1275.6 1309.0 1514.8 1263.6 1352.1 1105.5 1113.8 768.91 1047.5 True False 1299.997848231913 1126.2521589896483 1131.2449898223138 1250.2686163176836 1149.3076031066998 1338.4991016085742 1022.1112449568442 1084.2584058677173 1304.7841110355496 1181.9568285140467 1.099869146545959 0.9528708086619118 0.9570950161052094 1.0577955016254852 0.9723769729826821 1.1324433086877903 0.8647619103329179 0.9173418010798621 1.1039185861601402 1.0 10.206961626077582 -7.2688482891672335 24.980558206854415 0.9646174057840856 1.0207950258991343 0.10235380959647722 0.07997852603349799 1419.176273003028 4785004.479110767 0.03266838935518419 0.022575181616594196 5.384578475856952e-08 7.2688482891672335 0.056177620115048676 IKWDEQTSNTKGDDDEES(ph)DEEAVK ddPTM_A459_Selumetinib_30min_R1 1 IKWDEQTSNTKGDDDEESDEEAVK 24 2 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 IKWDEQTSNT(0.001)KGDDDEES(0.999)DEEAVK 82.36200000000002 0.00020779 8055800.0 757.97 947.35 901.51 1033.4 684.09 815.43 959.62 572.45 351.47 908.23 True False 775.6292262471216 836.4338215889335 779.0898936399651 852.9360893204998 622.2141802858991 807.2275145512019 887.2350908055051 557.2667664203399 596.4189196468564 1024.8101674093675 0.7568516110723666 0.8161841560406906 0.7602284973513073 0.8322869117083892 0.6071506705078887 0.7876849198245213 0.8657555506580887 0.5437756026846051 0.5819799008772057 1.0 10.001140978879643 -6.198720414762092 24.999396497133542 0.71781111992563 0.7909332792096728 0.042789890764444616 0.13108654454544838 697.8280434536312 278148.73573022167 0.03857680156514517 0.049802432886675865 6.328191094714984e-07 6.198720414762092 0.07312215928404286 IKWDEQTSNTKGDDDEES(ph)DEEAVKK ddPTM_A459_Selumetinib_30min_R1 1 IKWDEQTSNTKGDDDEESDEEAVKK 25 3 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 IKWDEQT(0.001)S(0.002)NT(0.002)KGDDDEES(0.995)DEEAVKK 66.137 0.0014583 70160000.0 3089.8 4313.9 6219.6 7276.7 3366.5 4466.6 3502.0 3206.0 2317.9 3219.9 True False 3161.7863282957846 3808.8265825222993 5375.012481817313 6005.960945576234 3062.00066940385 4421.670059348319 3237.8413205236243 3120.9664654443345 3933.3070072821274 3633.2055294819866 0.8702470318948855 1.0483377699431589 1.4794132724397975 1.6530749215370013 0.8427821229922059 1.2170162198279904 0.8911803348998172 0.859011812053835 1.0825996424823587 1.0 11.8270272656033 -6.311353322281635 24.999890147783024 0.9822489425353571 1.2629282373694697 0.27131864089010194 0.22533555493601806 544.9011989082758 272917.70747708 0.07511907366516657 0.08517711564645684 4.88254975627541e-07 6.311353322281635 0.2806792948341126 IKWGDAGAEYVVESTGVFTTMEK ddPTM_A459_Selumetinib_30min_R1 3 IKWGDAGAEYVVESTGVFTTMEK 23 1 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ;; 163.91 8.771699999999998e-10 53933100.0 16774.399999999998 16667.8 30762.1 25796.7 23057.9 17383.7 15873.199999999999 16505.5 11247.8 11223.18 False True 17165.210882699466 14716.326227350008 26584.775784119935 21291.790609032458 20972.317016202876 17208.835761136732 14675.871744413362 16067.720522579995 19086.6950931912 12663.784476030813 1.3554566500392249 1.162079649665873 2.099275760294079 1.6813134059042283 1.656086066206979 1.3589015032361373 1.158885147815876 1.268792954664692 1.5071872969188045 1.0 13.62842098723072 -6.8976861997028305 4.405439391412059 1.256194974228138 1.5993234614006646 0.30456053927895876 0.2549528625715962 0.3068592735287812 10.520722902125447 0.09768761346574428 0.08563738293035911 1.265650515331949e-07 6.8976861997028305 0.34312848717252664 ILASMPS(ph)RTIGRSRGAIIS(ph)QYYNR ddPTM_A459_Selumetinib_30min_R2 1 ILASMPSRTIGRSRGAIISQYYNR 24 3 K7ENM6;K7ENC4;K7ERH0;Q7Z403-2;Q7Z403 K7ENM6 TMC6 Transmembrane channel-like protein 6 2 ILAS(0.029)MPS(0.809)RT(0.155)IGRS(0.135)RGAIIS(0.827)QY(0.023)Y(0.023)NR 55.127 0.042064 0.0 1186.7 1006.5 1999.7 1257.8 1001.6 1727.9 1153.6 765.06 752.2 1156.0 True False 1120.7479647364903 1083.6953135924111 1871.0414791087373 1086.4854701739757 875.770053582391 1965.9025406855071 1207.2446858150345 767.286197937499 902.6610182240338 1122.6232763512928 0.9983295272293858 0.9653241086489817 1.666669058555355 0.9678094985748285 0.7801103647421113 1.7511685193941535 1.0753782780442385 0.6834761171452842 0.8040640500149151 1.0 10.132658162069811 -7.59618031129666 6.44512609668425 0.8148155142921121 1.1904601822167007 0.2219675448522821 0.29985197074629294 0.3164758077512042 21.90249261430717 0.14472051703991196 0.08272848343949718 2.5340763089273834e-08 7.59618031129666 0.3756446679245886 ILAT(ph)PPQEDAPSVDIANIR ddPTM_A459_Selumetinib_30min_R1 2 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 ILAT(0.999)PPQEDAPS(0.001)VDIANIR;ILAT(1)PPQEDAPSVDIANIR 245.67 1.9869999999999998e-30 88466000.0 13155.8 14447.1 14302.599999999999 15480.6 14441.400000000001 11662.2 12599.0 14016.900000000001 7215.3 11301.5 True False 13462.304543269363 12755.626815725425 12360.385478558153 12777.203816852074 13135.177919836251 11544.888856430385 11648.64728648691 13645.126278692056 12243.837115338334 12752.157610932229 1.0556883747836003 1.0002720484563508 0.9692779728476525 1.0019640759378925 1.030035725764216 0.9053282753134363 0.9134648144954469 1.0700249083334963 0.9601384713785125 1.0 13.638453745162455 -4.791573555265352 2.8738849044658035 0.9811352756959212 1.0679649318986606 0.18533186200545315 0.046912678143331 0.723250009285388 8.52162888412039 0.012436027371766646 0.14741700758564508 1.6159445148376377e-05 4.791573555265352 0.08682965620273941 ILAT(ph)PPQEDAPSVDIANIR ddPTM_A459_Selumetinib_30min_R2 4 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 ILAT(1)PPQEDAPSVDIANIR;ILAT(1)PPQEDAPSVDIANIR;ILAT(0.991)PPQEDAPS(0.009)VDIANIR;ILAT(1)PPQEDAPSVDIANIR 195.17 7.8648e-15 25946800.0 221782.0 188774.0 224591.0 230637.0 256842.0 181750.0 191506.0 203400.0 190006.0 212764.0 True False 209456.24430368925 203252.35879592068 210141.05957619168 199223.84272898294 224575.21176338696 206784.41273776896 200411.40846193978 203991.86032531713 228012.50921121525 206620.95049273936 1.0137221990518794 0.9836967563609332 1.0170365544977784 0.9641996237742777 1.086894679498043 1.0007911213487295 0.9699471809804796 0.9872757812741036 1.1035304438754268 1.0 17.6566270192476 ILATDVSSKNT(ph)PDSK ddPTM_A459_Selumetinib_30min_R2 1 ILATDVSSKNTPDSK 15 1 Q03188;H0Y8J2;Q03188-2 Q03188 CENPC Centromere protein C 1 ILATDVS(0.004)S(0.036)KNT(0.857)PDS(0.104)K 83.964 0.031128 11789000.0 47155.0 48618.0 39997.0 42576.0 38692.0 25093.0 31163.0 34482.0 26826.0 50267.0 True False 44534.31387642134 52346.84426849066 37423.63656544094 36777.07535230336 33831.16504913124 28549.332978425526 32612.141248313033 34582.3369111976 32191.949581066103 48815.661100649166 0.9122956213703539 1.0723370960921912 0.7666317677902608 0.7533868132293775 0.6930391658401885 0.5848396259463107 0.668067184034907 0.7084270935078602 0.6594594614767596 1.0 15.575056448802886 -5.4023674351254884 4.1412358588189795 0.7053906571258953 0.990666376261831 0.4736665817844046 0.11003708382764638 0.16667405676511524 4.750585929764686 0.02789324790958995 0.06161314030372153 3.959429047581663e-06 5.4023674351254884 0.28527571913593563 ILATDVSSKNTPDS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 ILATDVSSKNTPDSK 15 1 Q03188;H0Y8J2;Q03188-2 Q03188 CENPC Centromere protein C 1 ILATDVSS(0.003)KNT(0.192)PDS(0.806)K 179.74 6.4498e-09 0.0 1171.0 1643.7 1622.1 2115.2 1415.1 1157.4 1497.5 1237.0 811.89 859.04 True False 1198.2820216306443 1451.2548398646022 1401.8277295575058 1745.8200272215224 1287.104454856196 1145.757606835119 1384.5423693558325 1204.1907416577185 1377.7180319005502 969.3061517581932 1.2362265724375308 1.4972099756431112 1.4462177166778274 1.801102803334979 1.3278616384736224 1.182038930380114 1.4283850018329665 1.2423223967716244 1.4213445663184452 1.0 9.920808597276682 -6.501108339590492 24.797645089211365 1.277937780393954 1.5009164681658376 0.30096526332153206 0.1714912813149379 920.597102019208 1048609.964941228 0.052151421853713846 0.05858700430996634 3.154217670529745e-07 6.501108339590492 0.22297868777188357 ILATPPQEDAPS(ph)VDIANIR ddPTM_A459_Selumetinib_30min_R1 1 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 ILATPPQEDAPS(1)VDIANIR 133.41 0.00015042 2140200.0 835.27 881.95 1083.6 1187.1 859.75 803.78 874.71 974.11 550.02 672.44 True False 854.7301658475042 778.6908839925686 936.4530717887387 979.7952696268293 781.9857643011909 795.6947029738477 808.7299204669392 948.2734384447849 933.3437681286146 758.7542241202729 1.1264914759960767 1.0262755174713012 1.2341981659139971 1.2913210081470576 1.0306180044109192 1.048685697791541 1.0658654604587012 1.2497768161281047 1.2301002596865502 1.0 9.567488832906347 -11.043964790068975 3.214703269123816 0.9958840245022786 1.1428452319987101 0.17201619024952564 0.09522658024136389 75883047.62714863 123841496.83443837 2872313.508949608 0.025596446542548973 9.037227390452168e-12 11.043964790068975 0.1469612074964315 ILATPPQEDAPSVDIANIR ddPTM_A459_Selumetinib_30min_R1 1 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 104.09 0.013022999999999998 10287000.0 1677.8 1910.2 2430.0 2034.0 1817.6 2123.7 1812.7 1856.7 1235.9 1846.7 False True 1716.889475569509 1686.5528959721119 2100.019347034548 1678.800082908745 1653.1984009233433 2102.3375061653196 1675.966579586858 1807.4542845884275 2097.232033435429 2083.7419333812795 0.8239453495008949 0.8093866466637495 1.007811626474712 0.8056660261112867 0.7933796284651742 1.0089241246654115 0.8043062112145883 0.8674079335992816 1.0064739782974272 1.0 11.024960898897966 -8.260170836077807 21.234592904396074 1.003237131059799 0.866398537102907 0.34373574659729644 0.07632919898751152 15.167843768345609 254023.1071061596 0.057842271446779205 0.019026422543504114 5.493247464394673e-09 8.260170836077807 -0.1368385939568919 ILATPPQEDAPSVDIANIR ddPTM_A459_Selumetinib_30min_R2 2 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 ; 250.46 1.4577e-36 19692900.0 98743.0 87413.0 93746.0 113347.0 104885.0 77732.0 77421.0 102463.0 75246.0 85244.0 False True 93255.2593595477 94117.29602290477 87714.48442292739 97908.94306551885 91708.4086162031 88438.87741915969 81021.22990680105 102761.15036633729 90297.30254890425 82782.78422948929 1.1265054712466152 1.1369187071794313 1.0595739831577362 1.1827210690823955 1.107819813863355 1.0683245102507142 0.9787207649623757 1.2413347934935872 1.0907739258754974 1.0 16.337043151028112 -6.527916574668835 22.361116014559492 1.0852034029381188 1.1252619382748061 0.09448147422524045 0.07144578135552622 119.18058389942638 528979.7680155413 0.023703116292435152 0.023820694829786066 2.9654009703244704e-07 6.527916574668835 0.04005853533668735 ILCKS(ph)PQSDPADTPTNTK ddPTM_A459_Selumetinib_30min_R2 2 ILCKSPQSDPADTPTNTK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 ILCKS(0.988)PQS(0.012)DPADTPTNTK;ILCKS(0.964)PQS(0.032)DPADT(0.002)PT(0.001)NTK 82.663 0.0051737 15701900.0 92090.0 163633.0 129463.0 66030.0 63975.0 55626.0 49951.0 47500.0 35058.0 128246.0 True False 86972.00646547848 176183.12493697682 121133.49152865671 57036.60009189658 55937.88855624343 63287.9765774478 52273.82047602875 47638.21713595171 42070.57960236396 124543.20475687552 0.6983279949737853 1.4146345862940424 0.972622245951716 0.4579663756303639 0.4491444448168926 0.5081608161681253 0.419724388641468 0.38250354348073573 0.3377990769106286 1.0 16.926286782800005 -5.708367789602542 4.695143864016329 0.4747933438229528 1.0845035421644298 0.49641137482882625 0.238653325633863 0.1382449021411652 6.323529574400427 0.06147826362983017 0.10676454598823168 1.957186495102875e-06 5.708367789602542 0.609710198341477 ILDEIEEHNIK ddPTM_A459_Selumetinib_30min_R1 1 ILDEIEEHNIK 11 0 B5MCX3;Q15019;Q15019-3;Q15019-2;C9J2Q4;H7C2Y0 B5MCX3 SEPT2 Septin-2 0 87.713 0.044492 2490300.0 1378.2 1438.1 1469.0 1517.1 1531.4 1252.0 1323.0 1175.2 727.42 1198.0 False True 1410.3093784896269 1269.7265834454483 1269.5178686394038 1252.16696449403 1392.88514039063 1239.4060167250461 1223.2050448465898 1144.0298784124086 1234.3786113452547 1351.7749695081893 1.0433018884812861 0.9393032213841093 0.9391488208287265 0.9263131754463546 1.0304119929794215 0.9168730333688411 0.9048880711939972 0.8463168088018646 0.913153919246155 1.0 10.400639290279655 -6.975074228248307 24.997642587866697 0.9043681523440393 0.9693744023854127 0.2410878349093356 0.050453801073454096 297.12787401131436 297983.63007339044 0.017427795262279167 0.015369325642801902 1.0590726963296066e-07 6.975074228248307 0.06500625004137339 ILDEIEEHNIK ddPTM_A459_Selumetinib_30min_R2 1 ILDEIEEHNIK 11 0 B5MCX3;Q15019;Q15019-3;Q15019-2;C9J2Q4;H7C2Y0 B5MCX3 SEPT2 Septin-2 0 95.094 0.030298 1600900.0 6802.4 6697.5 8046.2 8342.2 7684.4 5537.7 6914.0 5309.2 8454.3 7388.8 False True 6424.349840164745 7211.176714143241 7528.516252040168 7205.977968902324 6719.016972592378 6300.467908764477 7235.514699831094 5324.648893014623 10145.39623287882 7175.46614559207 0.89532160138631 1.0049767593946644 1.0492023931664676 1.004252242668443 0.9363875232997801 0.8780569486255455 1.0083685927883461 0.7420631335966356 1.4139006479894265 1.0 12.808856842455885 -8.261290622006355 24.999999891956325 1.206950302212282 0.9479044046144675 0.421221085036783 0.12496133571569473 12.244717831604122 2058819.3784649076 0.09198657876079225 0.029627823142766622 5.479101906330446e-09 8.261290622006355 -0.2590458975978146 ILDPEGLALGAVIAS(ph)SKK ddPTM_A459_Selumetinib_30min_R1 1 ILDPEGLALGAVIASSKK 18 1 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 ILDPEGLALGAVIAS(0.702)S(0.298)KK 121.21 0.00048081 8495200.0 2016.5 1995.6 2485.5 2289.8 2131.5 1708.8 2345.2 1869.7 1021.7 1800.7 True False 2063.480526574034 1761.95422427073 2147.982751874225 1889.9294148694414 1938.7062013468894 1691.6110234662608 2168.299675868648 1820.1094823584754 1733.7502779844456 2031.837385303337 1.0155736583545403 0.8671728539967211 1.057162727396882 0.9301578111219221 0.954164056321592 0.8325523664944854 1.0671620138266815 0.8957948581533496 0.8532918483166951 1.0 10.988569227714958 -5.907028722034392 22.82219386697078 0.9311857202486861 0.9728517355649496 0.06722164649477591 0.07804152534886294 29.159623445605906 7137.418113123769 0.021332464916783908 0.03164116042644821 1.2387146615161084e-06 5.907028722034392 0.04166601531626357 ILDQMPATPS(ph)SPMYVD ddPTM_A459_Selumetinib_30min_R1 2 ILDQMPATPSSPMYVD 16 0 P45985;P45985-2 P45985 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 1 ILDQMPAT(0.039)PS(0.611)S(0.35)PMYVD;ILDQMPAT(0.046)PS(0.594)S(0.36)PMYVD 87.647 0.014565 15945700.0 9710.2 13137.1 10244.9 10775.599999999999 10740.2 9419.4 10103.4 8441.1 4189.700000000001 7677.7 True False 9936.428767239859 11599.002224727896 8853.6988512075 8893.843743063659 9768.750806336318 9324.649388130909 9341.292403705995 8217.214607442973 7109.6148964191425 8663.207582131075 1.1469687956842864 1.338880791527177 1.021988537994788 1.0266224904281755 1.1276136135171875 1.0763506818610855 1.0782717965772346 0.9485187246802191 0.8206677294774273 1.0 13.080685571281817 -5.749353510722173 0.35392902528019893 0.9239062890921937 1.3229181006582873 0.4714147717406736 0.09377330076562011 3.015759038944652 0.5010585638889553 0.10206729338617593 0.48612645092952805 1.7809285219163992e-06 5.749353510722173 0.39901181156609355 ILDSVGIEADDDRLNK ddPTM_A459_Selumetinib_30min_R1 2 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 ; 164.41 6.9825e-05 97328000.0 5723.1 7012.8 8279.9 8517.0 6979.200000000001 6522.1 6004.7 6536.7 4097.8 5381.6 False True 5856.43709478594 6191.738115837728 7155.535058235121 7029.665833890745 6347.93259227784 6456.493595592995 5551.760644588293 6363.325481805982 6953.66730852957 6072.380781223096 0.964438381877353 1.0196557724086912 1.1783739057276077 1.1576457549611756 1.0453778873529802 1.0632557193313117 0.9142642473534177 1.0479127892444657 1.145130313637704 1.0 12.56804654543486 -6.689881687223885 3.036662703597654 1.028404099192361 1.0833675866378245 0.06309579910973695 0.07884653148421787 0.725477886761554 13.535494207626916 0.030493324981441357 0.02954902589940847 2.0422942413792756e-07 6.689881687223885 0.05496348744546342 ILDSVGIEADDDRLNK ddPTM_A459_Selumetinib_30min_R2 2 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 ; 148.18 0.00083361 45367000.0 169443.0 165455.0 162264.0 192926.0 200550.0 148015.0 166421.0 169300.0 135343.0 168642.0 False True 160026.03639407185 178144.86647832295 151824.11089968492 166649.14598408717 175355.11606025195 168402.72270360857 174159.90625695523 169792.6349708763 162415.38179938248 163772.86727546234 0.977121784922478 1.0877556792034864 0.9270406839999945 1.0175626082419806 1.0707214142212491 1.0282699784474 1.0634234421995075 1.0367568071290396 0.9917111698740878 1.0 17.321336835753172 ILEDHGS(ph)PAGEIDDEDKDKDETETVK ddPTM_A459_Selumetinib_30min_R1 2 ILEDHGSPAGEIDDEDKDKDETETVK 26 2 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 ILEDHGS(0.998)PAGEIDDEDKDKDET(0.002)ET(0.001)VK;ILEDHGS(1)PAGEIDDEDKDKDETETVK 64.318 0.00071295 22810200.0 1804.22 2231.68 2648.83 2806.16 1731.58 2543.7 2017.44 2190.07 1878.88 2264.58 True False 1846.2548155990107 1970.3938681201162 2289.133434981694 2316.116834147101 1574.9588947352786 2518.112687494809 1865.2628765497382 2131.9822292500558 3188.322132034273 2555.2609018771736 0.7225308438143029 0.7711125962411917 0.8958511568427419 0.9064110958084985 0.6163593289351648 0.985462065985092 0.7299696383956168 0.8343501157489772 1.2477481769834278 1.0 11.319254888008025 -8.195689839063618 7.47111894968279 1.1225625385119287 0.808917216210636 0.5486562833066977 0.11473173974088825 0.1775686780917193 17.870248376706936 0.07453864202685336 0.027729612252262087 6.3725046484066585e-09 8.195689839063618 -0.3136453223012927 ILEDHGS(ph)PAGEIDDEDKDKDETETVK ddPTM_A459_Selumetinib_30min_R2 1 ILEDHGSPAGEIDDEDKDKDETETVK 26 2 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 ILEDHGS(0.997)PAGEIDDEDKDKDET(0.001)ET(0.001)VK 40.994 0.038435 35592000.0 265140.0 240420.0 196340.0 166910.0 137310.0 103170.0 185100.0 178420.0 87685.0 181290.0 True False 250404.58023951514 258859.44092785713 183707.69815882895 144176.57006419028 120059.89023302533 117380.7310159869 193707.51676869154 178939.17266097877 105224.45012360322 176055.68665201176 1.4223032780216862 1.4703270644106694 1.043463586166018 0.8189259478403949 0.6819426995864858 0.6667250189310804 1.1002627660165845 1.0163782611274945 0.597677087997662 1.0 17.42567230187732 -5.410289328246854 2.8512919035624478 0.8393630746241749 1.4556114467516803 0.701548618501657 0.15599238274781377 0.15075043162666238 2.3294208659552984 0.045254024410322044 0.11180409472762584 3.887860483023363e-06 5.410289328246854 0.6162483721275054 ILEGPQQSLSGS(ph)PLQPIPAS(ph)PPPQIPPGLRPR ddPTM_A459_Selumetinib_30min_R1 2 ILEGPQQSLSGSPLQPIPASPPPQIPPGLRPR 32 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 2 ILEGPQQS(0.128)LS(0.073)GS(0.8)PLQPIPAS(0.999)PPPQIPPGLRPR;ILEGPQQS(0.225)LS(0.177)GS(0.599)PLQPIPAS(0.999)PPPQIPPGLRPR 64.502 0.00055884 37589000.0 698.21 668.45 866.65 876.72 834.4300000000001 749.5 985.0 828.87 489.52 821.05 True False 714.4769345198393 590.1875632460259 748.9636901676915 723.6173100726427 758.9559538305823 741.9607104915513 910.7006569719507 806.885675050794 830.6796868737855 926.4397652042561 0.7712071106558294 0.6370490402210928 0.8084321488538052 0.7810732410790935 0.8192178081467089 0.8008731256564403 0.9830111909878616 0.870953196695844 0.8966364766204115 1.0 9.855553368654279 -6.448218471265527 0.3126739239415636 0.9954713920499937 0.6348179085936317 0.7026729698587779 0.055197477392812465 1.4585690291216549 0.25600896534232537 0.06923022505609946 0.18885522918616218 3.562718662481961e-07 6.448218471265527 -0.36065348345636195 ILEGPQQSLSGS(ph)PLQPIPASPPPQIPPGLRPR ddPTM_A459_Selumetinib_30min_R1 1 ILEGPQQSLSGSPLQPIPASPPPQIPPGLRPR 32 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 ILEGPQQS(0.083)LS(0.208)GS(0.45)PLQPIPAS(0.259)PPPQIPPGLRPR 72.514 3.5378e-05 112190000.0 377.73 446.69 520.83 716.47 613.43 364.42 471.39 410.46 174.59 280.15 True False 386.53037406536555 394.39132713945287 450.1041467144048 591.3519643075856 557.9453648098627 360.75426566688594 435.83267278173366 399.5732674380168 296.2664784509197 316.1099813920862 1.2227718098718738 1.2476395886097333 1.42388463892293 1.8707158872471785 1.7650355814542174 1.141230226512289 1.3787374598625841 1.2640324284553581 0.9372259526454065 1.0 8.304282779833697 -7.913226721595411 1.2014404678828805 0.9585071767934605 1.4733229470528204 0.41836994426086516 0.21759104023568557 0.5199247836282661 1.3523728125520698 0.21620837519245154 0.07799195392554989 1.2211619912862134e-08 7.913226721595411 0.5148157702593599 ILEGPQQSLSGS(ph)PLQPIPASPPPQIPPGLRPR ddPTM_A459_Selumetinib_30min_R2 1 ILEGPQQSLSGSPLQPIPASPPPQIPPGLRPR 32 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 ILEGPQQS(0.071)LS(0.221)GS(0.705)PLQPIPAS(0.004)PPPQIPPGLRPR 76.967 8.1037e-06 32638000.0 34677.0 24190.0 24728.0 26223.0 21152.0 18545.0 21411.0 18320.0 17945.0 29396.0 True False 32749.79116302964 26045.295216890656 23137.027401810705 22651.382162801838 18494.696658720786 21099.405415251313 22406.653925091632 18373.308166960745 21534.50142519315 28547.261100019565 1.1472130740769102 0.912357060302111 0.8104815141721196 0.793469541033704 0.6478623849034719 0.7391043694639011 0.7848968013634161 0.6436101909246962 0.7543456218004182 1.0 14.80106471578671 -4.550103647337791 1.1269212870598464 0.7454728203796264 1.518194567191075 0.6002357780630188 0.09410260745792365 1.5534442544683607 1.1729040032675613 0.027298392096784266 1.6114759817013868 2.8177103852278734e-05 4.550103647337791 0.7727217468114487 ILEGPQQSLSGSPLQPIPAS(ph)PPPQIPPGLRPR ddPTM_A459_Selumetinib_30min_R1 2 ILEGPQQSLSGSPLQPIPASPPPQIPPGLRPR 32 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 ILEGPQQSLSGSPLQPIPAS(1)PPPQIPPGLRPR;ILEGPQQSLSGSPLQPIPAS(1)PPPQIPPGLRPR 173.99 1.9589999999999999e-29 176100000.0 821.78 1140.03 1312.17 1360.1 1319.13 1285.02 1036.7 1054.3999999999999 467.67 849.31 True False 840.9258750944754 1006.5547576144315 1133.984521233877 1122.584067239029 1199.8149244113167 1272.093865504808 958.5008843480415 1026.4338868261098 793.6018327346445 958.3272114799666 0.8774934751104628 1.0503247174417452 1.1832957549881515 1.1713995530872976 1.251988788420622 1.3274107739675725 1.0001812250200082 1.071068289129518 0.8281115502387405 1.0 9.904374524002428 -7.4896990123313785 24.24839994728852 0.9768788113385435 1.1487642002702243 0.30178714145730867 0.12613119540243048 596.1497459359442 435679.0429561709 0.05652540054380553 0.038073804354277936 3.238180011544863e-08 7.4896990123313785 0.17188538893168082 ILEGPQQSLSGSPLQPIPAS(ph)PPPQIPPGLRPR ddPTM_A459_Selumetinib_30min_R2 2 ILEGPQQSLSGSPLQPIPASPPPQIPPGLRPR 32 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 ILEGPQQS(0.001)LSGSPLQPIPAS(0.999)PPPQIPPGLRPR;ILEGPQQSLSGSPLQPIPAS(1)PPPQIPPGLRPR 98.968 4.0545e-09 81753000.0 24287.0 26599.0 27410.0 27658.0 30438.0 23734.8 15959.1 18867.2 15692.8 29900.0 True False 22937.2257685642 28639.057770734795 25646.470441751528 23890.932687288772 26614.10632082749 27004.053256937546 16701.229772356714 18922.100428366888 18831.79849346733 29036.709310470313 0.7899388847169846 0.986305213325529 0.883243006896229 0.8227837538971391 0.9165675778291702 0.9299970243942273 0.5751763946038623 0.6516613238106768 0.6485514006463808 1.0 14.825590343541963 -7.247667306099199 24.86899931293622 0.6898190535351372 0.890700276798734 0.3203602815266181 0.11776628824001051 705.9367102418395 1274751.0315926452 0.0425551985357497 0.032782456483050386 5.653699139874664e-08 7.247667306099199 0.2008812232635968 ILELT(ph)PEPDRPR ddPTM_A459_Selumetinib_30min_R1 4 ILELTPEPDRPR 12 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 ILELT(1)PEPDRPR;ILELT(1)PEPDRPR;ILELT(1)PEPDRPR;ILELT(1)PEPDRPR 131.86 0.002721 241362000.0 9887.6 10418.3 12078.5 11902.3 11175.5 8925.9 10229.7 10157.2 5960.08 8424.0 True False 10117.961842079558 9198.52059266373 10438.306042451346 9823.786738842064 10164.677998194773 8836.113550068763 9458.065493021277 9887.798060764575 10113.820452979879 9505.30245670867 1.0644544861314207 0.9677251865006758 1.0981561175977286 1.0335059598138945 1.0693692330664057 0.9295983573707741 0.9950304617972409 1.0402402349423343 1.064018793619947 1.0 13.214516818516586 ILELT(ph)PEPDRPR ddPTM_A459_Selumetinib_30min_R2 5 ILELTPEPDRPR 12 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 ILELT(1)PEPDRPR;ILELT(1)PEPDRPR;ILELT(1)PEPDRPR;ILELT(1)PEPDRPR;ILELT(1)PEPDRPR 120.29 0.0056324 179395500.0 97520.4 102315.1 125978.0 122867.0 131666.0 107037.0 103527.0 106843.3 91807.3 100490.2 True False 92100.60657309201 110162.3391751008 117872.71263447538 106132.30264260294 115124.93997102545 121780.37516485606 108341.2106348587 107154.19631413942 110171.32531028903 97588.78682110466 0.943762183886215 1.1288421832422757 1.2078509885623878 1.0875460808541444 1.1796943452332005 1.2478931148933978 1.1101809353718568 1.098017505951474 1.128934264878711 1.0 16.57442776784019 -4.764410110242799 5.537645737433798 1.141210240602173 0.9347595819641356 0.42082881595790755 0.06565906319059908 0.13350612714613305 13.198695008042487 0.01594656627043204 0.10548149786036706 1.7202433583246952e-05 4.764410110242799 -0.20645065863803735 ILENEKDLEEAEEYKEAR ddPTM_A459_Selumetinib_30min_R1 1 ILENEKDLEEAEEYKEAR 18 2 E5RIW3;E5RJD8;E5RHG6;O75347 E5RIW3 TBCA Tubulin-specific chaperone A 0 55.815 0.041971 7517000.0 2237.5 2160.9 2905.4 3772.6 2592.9 2779.7 2512.5 2284.9 1565.1 2220.2 False True 2289.6293965828922 1907.9008234248454 2510.8626382198245 3113.7862304727278 2358.372652813676 2751.738741765665 2322.9801021746453 2224.2970295988043 2655.860389618731 2505.1842965793658 0.9139564700725623 0.7615810246096207 1.002266636290277 1.2429369905936105 0.9413968688985678 1.0984176874822944 0.9272691455660543 0.8878776035104119 1.0601457119322923 1.0 11.290701025400276 -5.339071166075071 7.1955446145126265 1.0213450851086188 0.838507650281179 0.3433883907490437 0.10094046901667073 0.2719653449319033 21.80557195098978 0.02705670701248707 0.05688673484552996 4.580668190126592e-06 5.339071166075071 -0.18283743482743975 ILENSEDS(ph)SPECLF ddPTM_A459_Selumetinib_30min_R1 2 ILENSEDSSPECLF 14 0 A0A087WSW7;F6XU50;A0A0B4J1V9;Q9NRZ9-6;Q9NRZ9-5;Q9NRZ9-3;Q9NRZ9-2;Q9NRZ9 A0A087WSW7 HELLS Lymphoid-specific helicase 1 ILENSEDS(0.845)S(0.155)PECLF;ILENSEDS(0.787)S(0.213)PECLF 116.98 0.0025715 11569300.0 1205.03 2221.13 1677.3200000000002 2278.3500000000004 1957.45 1802.0100000000002 1661.96 1523.31 698.41 1183.25 True False 1233.1048544197913 1961.079067024678 1449.5491568592545 1880.4789424263217 1780.398993115866 1783.8834154941694 1536.5970191483273 1482.9068703917694 1185.1507601518224 1335.1316633310223 0.9235829606072826 1.4688282218788657 1.0856975358091439 1.4084595505245614 1.333500689118514 1.3361104859453004 1.1508954969389826 1.1106821230589816 0.8876658330422542 1.0 10.382766304229232 -7.84878040092148 1.9030543529036754 0.9506871674855675 1.2684503003281924 0.37870146164988405 0.153816582153096 0.3418757915230365 2.3542663308717553 0.1120047528173451 0.04210368739032992 1.4165098508261289e-08 7.84878040092148 0.3177631328426249 ILENSEDS(ph)SPECLF ddPTM_A459_Selumetinib_30min_R2 1 ILENSEDSSPECLF 14 0 A0A087WSW7;F6XU50;A0A0B4J1V9;Q9NRZ9-6;Q9NRZ9-5;Q9NRZ9-3;Q9NRZ9-2;Q9NRZ9 A0A087WSW7 HELLS Lymphoid-specific helicase 1 ILENS(0.003)EDS(0.897)S(0.1)PECLF 98.531 0.010329 962500.0 5422.3 4907.5 5609.0 6266.3 5281.4 6034.4 3715.5 5977.3 4580.9 5424.7 True False 5120.950273186712 5283.889469900405 5248.12304661745 5412.819130029559 4617.903315684944 6865.583825170801 3888.278112123579 5994.692953404715 5497.208001040248 5268.074815936731 0.9720724272356678 1.003001979758494 0.9962127019800623 1.027475751417758 0.8765827132361675 1.3032434171969922 0.7380833127807797 1.1379285911562707 1.0434946717936415 1.0 12.363060119211422 ILEQQNSS(ph)RTLEK ddPTM_A459_Selumetinib_30min_R1 1 ILEQQNSSRTLEK 13 1 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;Q5JXL7 E7EPK1 SEPT7;DKFZp586I031 Septin-7 1 ILEQQNS(0.009)S(0.733)RT(0.257)LEK 69.352 0.035274 25668000.0 4086.7 4089.6 6232.9 6579.0 4463.7 4400.3 4547.2 3738.7 2638.8 3204.2 True False 4181.912158666055 3610.7877307965396 5386.50641486898 5430.101153125187 4059.9591231302406 4356.036977152732 4204.201043028278 3639.537530990873 4477.8508696734425 3615.490281551034 1.1566653020768258 0.998699332486526 1.4898412097399376 1.501898976422 1.1229345972376756 1.2048260783276137 1.1628301324667616 1.006651172473771 1.238518297925685 1.0 11.81997558295918 -6.992012020624211 1.5788823047029654 1.0985141545494181 1.2707378033334173 0.18572663427319602 0.15691660604212518 0.7450857350758785 3.7646063042632356 0.08304911338219013 0.06253518504897312 1.0185631953522464e-07 6.992012020624211 0.1722236487839992 ILGQS(ph)SPEKK ddPTM_A459_Selumetinib_30min_R1 2 ILGQSSPEKK 10 1 H7C485;P29374-3;P29374-2;P29374 H7C485 ARID4A AT-rich interactive domain-containing protein 4A 1 ILGQS(0.741)S(0.259)PEKK;ILGQS(0.975)S(0.025)PEKK 181.66 0.00025032 61947000.0 8004.6 8870.4 10721.3 11154.1 7510.4 8756.9 7686.3 7416.3 4993.4 7850.1 True False 8191.091605759742 7831.8494442629135 9265.406347885388 9206.245823388615 6831.085646068814 8668.813536629039 7106.516202724371 7219.595632462518 8473.435096493626 8857.73680144928 0.9247386538307999 0.8841817746245842 1.046024120559713 1.0393451543832632 0.7711998899031555 0.9786713842310905 0.8022948030654536 0.8150609793780806 0.9566140072153898 1.0 13.112722414320938 -6.245556966886498 24.994956850471876 0.8783775100609756 0.9723624936517479 0.19395172736014765 0.08497825447663293 1294.179273971953 2036715.082716793 0.02494789093437122 0.03210525438837993 5.681238652377527e-07 6.245556966886498 0.09398498359077223 ILGQS(ph)SPEKK ddPTM_A459_Selumetinib_30min_R2 1 ILGQSSPEKK 10 1 H7C485;P29374-3;P29374-2;P29374 H7C485 ARID4A AT-rich interactive domain-containing protein 4A 1 ILGQS(0.724)S(0.276)PEKK 145.09 0.0016422999999999993 9528200.0 91058.0 71578.0 76095.0 71505.0 65043.0 48766.0 73490.0 67733.0 38989.0 63150.0 True False 85997.36089405528 77067.80244045466 71199.1305459716 61765.89564699484 56871.716848202355 55483.07384632764 76907.43061767235 67930.09181619823 46787.88944368103 61326.69541659529 1.4022826488508948 1.2566762633618076 1.1609810387191477 1.0071616484047614 0.9273566178948655 0.9047132487643165 1.2540612223638719 1.1076757251429534 0.762928592937359 1.0 15.90422759313141 -5.267552611023067 1.4927710535481649 1.0026885127162464 1.4042868561984732 0.5515054297422322 0.1232935991835526 0.45193824482540995 1.6272611206201202 0.03894622694767825 0.2039668182274516 5.400666863901757e-06 5.267552611023067 0.4015983434822268 ILGSAS(ph)PEEEQEKPILDRPTR ddPTM_A459_Selumetinib_30min_R1 2 ILGSASPEEEQEKPILDRPTR 21 2 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 ILGS(0.04)AS(0.938)PEEEQEKPILDRPT(0.022)R;ILGS(0.047)AS(0.951)PEEEQEKPILDRPT(0.002)R 83.064 0.0016239000000000002 107155000.0 4933.9 5295.4 6173.2 5543.9 4931.299999999999 4448.9 4460.6 4572.9 2826.8 3642.2000000000003 True False 5048.850270301821 4675.412106235326 5334.913346960355 4575.761936891735 4485.264785691729 4404.148105277999 4124.13335075034 4451.611837127384 4796.873138696718 4109.711848032328 1.2285168539782514 1.1376496161096665 1.2981234559096002 1.1134021328241164 1.091381817399001 1.0716440149901612 1.003509127464719 1.08319317794963 1.1672042508268294 1.0 12.004821527720296 -5.945743492528603 6.8617977804012105 1.0731733975199622 1.2130122233675624 0.5840626844798799 0.05716529636151085 0.15547151878249924 15.459764674477116 0.016070345628892695 0.023899992126124224 1.1330693907335317e-06 5.945743492528603 0.1398388258476002 ILGSAS(ph)PEEEQEKPILDRPTR ddPTM_A459_Selumetinib_30min_R2 3 ILGSASPEEEQEKPILDRPTR 21 2 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 ILGS(0.275)AS(0.725)PEEEQEKPILDRPTR;ILGS(0.273)AS(0.721)PEEEQEKPILDRPT(0.006)R;ILGS(0.221)AS(0.778)PEEEQEKPILDRPT(0.001)R 61.015 0.0072866 107804000.0 168979.0 177345.0 183804.0 178834.0 179185.0 146034.0 145687.0 139636.0 124229.0 176025.0 True False 159587.82365653283 190946.79124594765 171978.25075066352 154476.5006941424 156674.17836577547 166148.85793533616 152461.73417331383 140042.31764201567 149078.27124827632 170942.70088212486 0.9335749513316635 1.1170221966810785 1.0060578770733986 0.903674154538269 0.9165303786431432 0.9719564338105647 0.8918879448292165 0.8192354333899472 0.8720949796568069 1.0 17.383153296588183 -5.703424530852777 4.457782660440448 0.9049070970545314 1.0328982656600942 0.38159123817425444 0.06273433808064817 0.19256631311277514 7.71457447118565 0.01749465433279509 0.03054304988970211 1.9795909930592706e-06 5.703424530852777 0.1279911686055628 ILIPS(ph)DIESSK ddPTM_A459_Selumetinib_30min_R1 2 ILIPSDIESSK 11 0 P30414;A0A087WYW3 P30414 NKTR NK-tumor recognition protein;Putative peptidyl-prolyl cis-trans isomerase 1 ILIPS(1)DIESSK;ILIPS(0.997)DIES(0.003)S(0.001)K 117.93 0.0054555 31456000.0 9120.0 9136.8 9547.900000000001 10338.1 9123.5 8365.7 8594.7 8419.3 4838.299999999999 8197.9 True False 9332.478255569153 8067.05920841692 8251.347622860556 8532.74490517153 8298.281035884753 8281.548653447864 7946.394859367335 8195.992814259354 8210.241724549423 9250.180319308163 1.0088969007543784 0.8720975083673038 0.89202019182667 0.9224409266228994 0.8970939754075405 0.8952851044602399 0.859052968165453 0.8860360048497246 0.8875763975554026 1.0 13.175265773884124 -4.753765390478524 24.92087445270124 0.8964605739984126 1.0088971105580693 0.4288974633248047 0.036874630242551894 231.42898043503124 751489.7259580555 0.00848956833130733 0.08808298875636071 1.762928137790007e-05 4.753765390478524 0.11243653655965669 ILIPS(ph)DIESSK ddPTM_A459_Selumetinib_30min_R2 2 ILIPSDIESSK 11 0 P30414;A0A087WYW3 P30414 NKTR NK-tumor recognition protein;Putative peptidyl-prolyl cis-trans isomerase 1 ILIPS(0.998)DIES(0.002)SK;ILIPS(0.977)DIES(0.019)S(0.004)K 91.202 0.02734 0.0 18675.300000000003 19815.8 23113.0 19991.7 23363.0 15910.0 18657.2 18249.1 16090.4 19107.9 True False 17637.401589149216 21335.608142160476 21625.93474353165 17268.79597239391 20427.93107212999 18101.458083399757 19524.79676854044 18302.201859698867 19308.929603339533 18556.205278713565 0.9504853672524124 1.1497829336171042 1.1654287295657086 0.9306210894424365 1.1008679180523804 0.9754935242155645 1.0521977136639018 0.9863116722843073 1.0405645611977274 1.0 14.179614090805858 -5.755146315681129 24.999999195029144 1.015543344643913 1.0946873766452858 0.20041593530405566 0.06927904244069383 229.06822577698307 909992.0655322447 0.018180993748698464 0.030514472030931328 1.757331461678038e-06 5.755146315681129 0.07914403200137277 ILIVTQT(ph)PHYMR ddPTM_A459_Selumetinib_30min_R1 3 ILIVTQTPHYMR 12 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 ILIVT(0.005)QT(0.995)PHYMR;ILIVT(0.002)QT(0.998)PHYMR;ILIVT(0.259)QT(0.741)PHYMR 170.0 0.00075853 109210000.0 6284.9 7822.0 7091.4 7386.900000000001 5815.9 6933.800000000001 6495.5 6041.1 3686.9 4964.5 True False 6431.325941713432 6906.196603650858 6128.426830271929 6096.916584286434 5289.852871880539 6864.052267386681 6005.539205442951 5880.870403741663 6256.400019478177 5601.74193332505 1.1480939354690984 1.232865898831494 1.0940216281320643 1.088396548226466 0.94432284365171 1.2253424647344215 1.0720842332481777 1.0498288699727603 1.1168668771152295 1.0 12.451659806080924 -5.381953907032084 5.264248743045093 1.0754874922710442 1.1895734876489674 0.29878467410362564 0.07183210040464492 0.2645986086148819 10.186293033451847 0.018509066891510828 0.039640479530088334 4.149980852809561e-06 5.381953907032084 0.11408599537792319 ILIVTQT(ph)PHYMR ddPTM_A459_Selumetinib_30min_R2 5 ILIVTQTPHYMR 12 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 ILIVT(0.007)QT(0.993)PHYMR;ILIVT(0.002)QT(0.998)PHYMR;ILIVT(0.003)QT(0.997)PHYMR;ILIVT(0.002)QT(0.998)PHYMR;ILIVT(0.015)QT(0.975)PHY(0.01)MR 162.94 0.0006727 95775000.0 413311.0 370295.0 396365.0 412499.0 360001.0 390507.0 300390.0 310124.0 257467.0 371691.0 True False 390340.829235024 398695.4358139121 370863.30742958136 356315.92459953466 314774.455930226 444295.7945804018 314358.73021149245 311026.40949620766 308967.59422904474 360959.31506080396 1.081398409594363 1.1045439726268083 1.0274379741858415 0.9871359727605669 0.8720496820457506 1.2308749935032421 0.8708979574568907 0.8616661117162607 0.8559623795191401 1.0 18.46147670969939 ILIVTQT(ph)PPYVK ddPTM_A459_Selumetinib_30min_R1 2 ILIVTQTPPYVK 12 0 A0A3B3ISF0;Q659C4-2;Q659C4;H0Y9K3;D6R9W6;D6RJB0;Q659C4-9;Q659C4-4 A0A3B3ISF0 LARP1B La-related protein 1B 1 ILIVT(0.039)QT(0.961)PPYVK;ILIVT(0.002)QT(0.996)PPY(0.002)VK 139.46 0.006397399999999999 0.0 5589.7 5532.4 6390.7 7950.5 5714.6 5320.0 4939.700000000001 4354.8 3461.6 4202.5 True False 5719.929134337155 4884.664036057015 5522.878041602339 6562.09442436872 5197.715438994573 5266.485630173522 4567.094452024714 4239.296557616029 5874.082374739123 4741.931810816497 1.2062444932864314 1.0301000163930956 1.1646894687528992 1.3838441137850979 1.0961177103260782 1.1106202788830706 0.9631295080218206 0.8940020073561704 1.2387530249465324 1.0 12.211259201614398 -6.843987096983563 2.4506709988227344 1.0185949272243924 1.1830887407735056 0.2710982064847327 0.11790184641895456 0.3945238764914253 4.836493985492446 0.04721575407637016 0.04150517552379152 1.4322304506281992e-07 6.843987096983563 0.1644938135491132 ILIVTQT(ph)PPYVK ddPTM_A459_Selumetinib_30min_R2 3 ILIVTQTPPYVK 12 0 A0A3B3ISF0;Q659C4-2;Q659C4;H0Y9K3;D6R9W6;D6RJB0;Q659C4-9;Q659C4-4 A0A3B3ISF0 LARP1B La-related protein 1B 1 ILIVT(0.044)QT(0.955)PPY(0.001)VK;ILIVT(0.256)QT(0.744)PPYVK;ILIVT(0.032)QT(0.968)PPYVK 134.61 0.0054419 0.0 62330.0 62200.0 60920.0 69210.0 69750.0 51011.0 52853.0 57008.0 49558.0 63618.0 True False 58865.948126759424 66970.53999547737 57000.47352468084 59783.47860609072 60987.38142708839 58037.302218246696 55310.76922623269 57173.88384181754 59470.984766214664 61781.183040585274 0.9528135466115828 1.0839957524200063 0.9226186796590817 0.9676648400665584 0.9871514015363639 0.9394009528778504 0.8952688586409547 0.9254255264788129 0.9626067653503334 1.0 15.91487987677664 -5.284317421199893 24.99517965567345 0.9469758077545167 1.0184046748921378 0.2975483588288471 0.04182232370531288 779.3998427805897 851525.1287291927 0.010718692705703258 0.02233496720813203 5.196160758684997e-06 5.284317421199893 0.07142886713762109 ILLDHEK ddPTM_A459_Selumetinib_30min_R2 1 ILLDHEK 7 0 P54136-2;P54136 P54136-2 RARS Arginine--tRNA ligase, cytoplasmic 0 110.81 0.021439 2022900.0 34776.0 31655.0 39414.0 40426.0 42928.0 32108.0 38601.0 36004.0 34237.0 37948.0 False True 32843.28913935804 34082.83671313241 36878.14615071851 34919.90906126025 37535.00085881078 36530.5855525958 40396.02298643041 36108.76567921695 41085.35666170731 36852.342639255075 0.8912130623786562 0.9248485787393991 1.0007001864634772 0.9475628022643967 1.0185241471956938 0.9912690194539617 1.096158889595274 0.9798228034695936 1.1148641773981345 1.0 15.169468711396588 -4.82070556448583 0.45675189048552833 1.0472522047211243 0.785740734537609 0.5570669653157425 0.04383252193840504 3.4658516465415747 0.5772642930466146 0.029474168532138193 0.49257632163842285 1.5111042794928381e-05 4.82070556448583 -0.2615114701835154 ILLVDS(ph)PGMGNADDEQQEEGTSSK ddPTM_A459_Selumetinib_30min_R1 1 ILLVDSPGMGNADDEQQEEGTSSK 24 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 ILLVDS(1)PGMGNADDEQQEEGTSSK 127.92 8.6417e-08 7406300.0 3277.0 3626.3 3686.8 5119.5 3801.3 3309.4 3237.1 2865.8 1905.0 2914.8 True False 3353.347724067995 3201.7311101788687 3186.152810142784 4225.475429917072 3457.473086174025 3276.110440694784 2992.9229407958387 2789.7896745696753 3232.645864304955 3288.9429725563186 1.019582203780693 0.9734833157323902 0.9687467483409596 1.2847518078529763 1.0512414216433545 0.9960982808249907 0.9099953893300864 0.8482329118650913 0.9828829174840916 1.0 11.683408277960527 -6.9983652268669445 3.1345652327007927 0.9237413761640029 1.0614931954577833 0.2881196427403995 0.09129935918317587 0.3302359408510012 6.691052162062376 0.038429794705173374 0.031218550110501113 1.0037712977610923e-07 6.9983652268669445 0.13775181929378044 ILMEHIHK ddPTM_A459_Selumetinib_30min_R1 1 ILMEHIHK 8 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 90.37 0.015997 8011700.0 5162.2 5702.1 6379.0 6012.8 5753.4 4562.3 5188.6 5518.9 2296.2 4336.6 False True 5282.469216107352 5034.495481165631 5512.766837338837 4962.777354234858 5233.005985845273 4516.407404236963 4797.219724634173 5372.52084408632 3896.483692187418 4893.244852061116 1.0795432020701534 1.0288664543416457 1.1266075996619642 1.0142098963522035 1.0694347297256226 0.9229882298521352 0.9803759815153138 1.0979464560869716 0.7962985319539353 1.0 12.256575759956268 -6.7471983996456695 24.95170737673385 0.9669468782140773 1.0625372228028886 0.3188375924162231 0.07576147480760964 302.91429062362147 530737.1533868347 0.023970650464341353 0.023863195996014205 1.7897880346798523e-07 6.7471983996456695 0.09559034458881133 ILNDVQDR ddPTM_A459_Selumetinib_30min_R2 1 ILNDVQDR 8 0 O00148;H0Y400;Q13838;Q13838-2;A0A0G2JJZ9 O00148;Q13838 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 163.15 0.0047835 2713500.0 18361.0 12140.0 18871.0 17408.0 21207.0 13912.0 16758.0 19096.0 17992.0 14935.0 False True 17340.569124906626 13071.098963747521 17656.860405191273 15037.000369525014 18542.787067014535 15828.251719437918 17537.280205347044 19151.56619848702 21590.902738482866 14503.787744209834 1.1955890027299445 0.9012196809737327 1.2173964978383114 1.0367636809583103 1.278478932127033 1.0913184885621918 1.2091517412303716 1.320452735261012 1.4886389072469937 1.0 13.824142096767286 -6.802808701366569 0.8964123805282456 1.2832466691702509 1.079564635539568 0.15315552150541734 0.1498897823271349 0.9020796936146652 1.563352116561126 0.0918332361254055 0.081634579388123 1.5746763273305784e-07 6.802808701366569 -0.20368203363068282 ILPPLEGPPAQASPSST(ph)MLGEGSQPDWPGGSR ddPTM_A459_Selumetinib_30min_R2 1 ILPPLEGPPAQASPSSTMLGEGSQPDWPGGSR 32 0 D6R9B8;C9J929;B5MBX1;A0A0C4DFT8;G3XAA4;Q9NQC1-3;Q9NQC1-2;Q9NQC1 D6R9B8 JADE2 Protein Jade-2 1 ILPPLEGPPAQAS(0.212)PS(0.212)S(0.256)T(0.311)MLGEGS(0.008)QPDWPGGSR 57.919 0.0018977 1121200.0 2317.5 1255.9 2556.6 2876.5 2763.0 1978.1 911.73 3632.5 1977.2 3547.0 True False 2188.702627687549 1352.2234916450163 2392.1111394156114 2484.7157377607255 2415.8872384666 2250.5653195960435 954.1272515587218 3643.0699736072515 2372.695247583835 3444.5888937872287 0.6354031482930121 0.3925645507607396 0.6944547559013792 0.7213388344374676 0.7013572048681839 0.6533625314925783 0.2769930697040847 1.0576211228509764 0.688818120462301 1.0 11.750116094504321 -7.781377478651756 24.99999549090345 0.9049146900832961 0.5919037605560344 0.46906643549620153 0.16213668181421512 236.30704420442078 296296.6121066298 0.08761159753106791 0.042174323254170185 1.654331432029051e-08 7.781377478651756 -0.3130109295272616 ILPPLS(ph)PPQHR ddPTM_A459_Selumetinib_30min_R1 1 ILPPLSPPQHR 11 0 A0A087WV20;A0A087WTU9;Q8TCU4-3;Q8TCU4-2;Q8TCU4 A0A087WV20 ALMS1 Alstrom syndrome protein 1 1 ILPPLS(1)PPQHR 113.52 0.0046627 10210000.0 4489.3 5432.9 6036.2 6779.6 5519.5 5087.6 5454.8 5425.4 3350.1 3949.7 True False 4593.891955342829 4796.813542313313 5216.517194473224 5595.670128853554 5020.262199546873 5036.423363171205 5043.340044315324 5281.5007678171205 5684.875018376916 4456.68246833597 1.0307873598762556 1.0763193421101729 1.1704933504991124 1.255568501595057 1.1264572325300373 1.1300835091919164 1.1316354889870355 1.1850745044865447 1.275584486614665 1.0 12.121754459506274 -5.127925213168916 3.4183637868733228 1.1661802816613636 1.0385559252819911 0.26040956171538576 0.07226140626051032 0.3067168696455375 6.423896661743784 0.018376135239546412 0.06246712786678488 7.4486023006040645e-06 5.127925213168916 -0.12762435637937242 ILPPLS(ph)PPQHR ddPTM_A459_Selumetinib_30min_R2 3 ILPPLSPPQHR 11 0 A0A087WV20;A0A087WTU9;Q8TCU4-3;Q8TCU4-2;Q8TCU4 A0A087WV20 ALMS1 Alstrom syndrome protein 1 1 ILPPLS(1)PPQHR;ILPPLS(1)PPQHR;ILPPLS(1)PPQHR 107.65 0.006896800000000001 9139600.0 48983.0 50275.0 51540.0 58275.0 60362.0 41158.9 41891.3 42833.2 38802.5 52232.0 True False 46260.720954485114 54130.93084039594 48223.97251250907 50337.84447001781 52778.785916873254 46828.16487170597 43839.32845603617 42957.837520582034 46564.08423243564 50723.92644496608 0.9120098580041235 1.0671675998727417 0.9507145028457255 0.992388562912866 1.040510654752578 0.923196766372436 0.864273165122588 0.846894957297716 0.9179905321989665 1.0 15.63037880569376 -6.9335554714491705 6.175548928079005 0.8943537492891501 0.9939847331580232 0.34499815832075653 0.05569686472354942 0.1925340946120215 13.45921559338344 0.018830582743298796 0.016538263732616264 1.1653181978806628e-07 6.9335554714491705 0.09963098386887304 ILPTS(ph)ETK ddPTM_A459_Selumetinib_30min_R1 1 ILPTSETK 8 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 ILPT(0.225)S(0.773)ET(0.002)K 97.597 0.020141 12209000.0 7468.3 8762.3 9072.7 9513.1 7375.0 7372.6 7593.4 7968.9 4963.3 6629.7 True False 7642.296859217879 7736.40584251724 7840.677172773804 7851.815668003532 6707.932552162001 7298.438337785209 7020.623724518587 7757.53888536474 8422.357594910645 7480.686573746617 1.0216036701816156 1.0341839303451192 1.0481226683511338 1.0496116353222695 0.8967001205081112 0.9756374987556615 0.9384999164591903 1.037008944150893 1.1258802934571288 1.0 12.868954970695253 -7.995514107119291 24.98420570036442 1.0691083113651891 0.9954586743631768 0.2098650998517121 0.054109789701122485 173.60929350240076 966920.0029416494 0.03139708991296673 0.014992180592750226 1.0103826798936208e-08 7.995514107119291 -0.07364963700201232 ILPTS(ph)ETK ddPTM_A459_Selumetinib_30min_R2 2 ILPTSETK 8 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 ILPT(0.448)S(0.542)ET(0.01)K;ILPT(0.425)S(0.561)ET(0.014)K 93.442 0.024057 16277800.0 181016.0 158467.0 158273.0 171149.0 159271.0 136859.0 155160.0 150995.0 120693.0 149822.0 True False 170955.8553844616 170620.9093482845 148089.88749461292 147838.21095150727 139261.95307919418 155710.0849676936 162375.24744370725 151434.37045143227 144834.9724441814 145496.24957569488 1.1749846190744682 1.1726825251225355 1.0178261496532164 1.0160963693747582 0.9571514969308038 1.0701999908711388 1.1160098484822527 1.0408128793220066 0.9954550228377573 1.0 17.150622440022047 -5.258133501881898 24.474480717244237 1.0300330641074562 1.173833596773946 0.6718340162901801 0.041081423573660694 131.10809875443448 970619.1508036681 0.011615545959898655 0.02819516217848043 5.519077570647953e-06 5.258133501881898 0.14380053266648973 ILQFEDILANTFYR ddPTM_A459_Selumetinib_30min_R1 2 ILQFEDILANTFYR 14 0 A0A494C0S0;Q9H3E2-2;Q9H3E2 A0A494C0S0 SNX25 Sorting nexin-25 0 ; 105.65 0.008112300000000001 30951000.0 6902.5 8718.6 9204.0 9795.900000000001 8836.900000000001 7465.4 7869.6 7381.2 4623.2 6346.9 False True 7063.314820073033 7697.822258832826 7954.147353953073 8085.229956817004 8037.603955281409 7390.304854040863 7275.989736148688 7185.426598483386 7845.23273483184 7161.586439041343 0.9862779539415202 1.0748766805170706 1.110668344459419 1.1289719150411177 1.1223217123324047 1.0319368364742012 1.0159745746394508 1.0033288936250324 1.0954601751454962 1.0 12.806063494248894 -6.836842854306324 9.115976823404004 1.0284627059743943 1.0879397256327927 0.27515735573776834 0.044702050732791467 0.4260238223514201 47.31150386066836 0.0164781334564822 0.014543330799013265 1.4559858211264013e-07 6.836842854306324 0.05947701965839847 ILS(ph)DVTHSAVFGVPASK ddPTM_A459_Selumetinib_30min_R1 2 ILSDVTHSAVFGVPASK 17 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 ILS(1)DVTHSAVFGVPASK;ILS(0.977)DVT(0.023)HSAVFGVPASK 223.29 2.9951e-12 141562700.0 4494.3 5786.5 5054.9 5626.099999999999 4903.56 4698.97 4811.4400000000005 4590.25 2607.75 4012.51 True False 4599.0084456145205 5109.013889929135 4368.472344578164 4643.607249976839 4460.033863793831 4651.702628123394 4448.5092070874325 4468.501658766645 4425.1612874757175 4527.554743657185 1.0157819631131877 1.1284267511257677 0.9648635062222305 1.0256324910222756 0.9850866784199691 1.0274205153764584 0.9825412300799918 0.986956958394977 0.9773843803159058 1.0 12.144516369885077 -5.273760021307767 24.998237848808426 0.9949033979635584 1.072104362117722 0.4980219009522534 0.0314542393304323 497.9354628632745 1010297.4452920047 0.007583572343496405 0.015977363279106635 5.32402368301581e-06 5.273760021307767 0.07720096415416355 ILS(ph)DVTHSAVFGVPASK ddPTM_A459_Selumetinib_30min_R2 3 ILSDVTHSAVFGVPASK 17 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 ILS(0.488)DVT(0.426)HS(0.086)AVFGVPASK;ILS(0.76)DVT(0.238)HS(0.002)AVFGVPASK;ILS(0.553)DVT(0.443)HS(0.004)AVFGVPASK 123.76 0.0013374 285459900.0 304789.4 303732.6 373702.9 465394.0 426144.0 288948.5 321568.5 346653.1 281574.2 310164.6 True False 287850.4253166394 327027.9137657604 349659.26227095263 402006.5343505703 372607.9809443035 328748.53306167375 336522.07242589403 347661.8031294903 337896.907840491 301209.3420935886 0.9556490622631537 1.0857163708559534 1.1608513196855301 1.3346416533975332 1.2370399216520007 1.0914287411428576 1.1172365043091308 1.154219854912297 1.1218008893479248 1.0 18.200406990738422 -10.452437373931279 14.774933304931002 0.9999999999997221 1.1457908034898368 0.16353139295375385 0.09402012026691274 0.0 0.0 0.09884552235461813 0.023973560546320136 3.5282766135296977e-11 10.452437373931279 0.14579080349011464 ILS(ph)LLEGQK ddPTM_A459_Selumetinib_30min_R1 2 ILSLLEGQK 9 0 J3QS00;I3L1M4;J3QRD1;A0A5F9ZI12;A0A5F9ZHI5;A0A5F9ZGX4;A0A5F9ZHN9;P51648;P51648-2;A0A5K1VW72 J3QS00 ALDH3A2 Fatty aldehyde dehydrogenase 1 ILS(1)LLEGQK;ILS(1)LLEGQK 107.85 0.012352 8711700.0 2647.5 2802.2 3095.3999999999996 3511.6000000000004 2638.3 3071.2 2959.5 3007.2 1715.23 2384.3 True False 2709.181598861767 2474.1171212925633 2675.0616818151193 2898.3649808959426 2399.6662308296973 3040.3065164264885 2736.26253229288 2927.439287237744 2910.6200345573666 2690.3481300487265 1.0070003835573127 0.9196271269353358 0.9943180408279243 1.0773196778973912 0.8919537973645945 1.1300792200344063 1.0170663423559694 1.0881265716287518 1.0818748704111578 1.0 11.393577153725879 -6.7720930203371 24.999999199874534 1.0660396044535605 0.9812178753222656 0.35176508664687 0.05782102300693531 242.83420603518775 569834.617168632 0.019572978033522488 0.017438822183840012 1.690078899535823e-07 6.7720930203371 -0.08482172913129493 ILS(ph)PDSFIK ddPTM_A459_Selumetinib_30min_R1 1 ILSPDSFIK 9 0 Q8IZT6-2;Q8IZT6 Q8IZT6-2 ASPM Abnormal spindle-like microcephaly-associated protein 1 ILS(0.975)PDS(0.025)FIK 100.82 0.017575 5051900.0 2633.3 4038.6 2857.7 2525.9 2575.8 2929.4 3114.2 3594.8 1638.4 3156.1 True False 2694.6507664901587 3565.758834505796 2469.6400362224804 2084.798982015338 2342.8193447944254 2899.932895682388 2879.2933867431952 3499.454226443947 2780.24513599855 3561.2161780173606 0.756665878113121 1.0012755913321063 0.6934822018014659 0.5854176994040307 0.6578705778256757 0.814309705089813 0.8085140701416748 0.9826570619456754 0.7807010293731729 1.0 11.798154299550747 -7.409237821088516 2.2056133985377055 0.9102077132581339 0.7454734335485595 0.2893425234569418 0.11721742132806755 0.4746166176712054 4.515756616709125 0.06737273395744604 0.03892825760691296 3.897285116156333e-08 7.409237821088516 -0.16473427970957433 ILS(ph)PDSFIK ddPTM_A459_Selumetinib_30min_R2 1 ILSPDSFIK 9 0 Q8IZT6-2;Q8IZT6 Q8IZT6-2 ASPM Abnormal spindle-like microcephaly-associated protein 1 ILS(0.972)PDS(0.028)FIK 101.3 0.013453 0.0 15611.0 11199.0 13843.0 17097.0 17656.0 17382.0 22482.0 21632.0 18161.0 15310.0 True False 14743.403115784391 12057.927289539417 12952.3564511188 14768.359106029935 15437.895433357318 19776.212721914173 23527.457547237856 21694.945538629603 21793.707460737398 14867.96051984282 0.9916224283826828 0.8110007605580385 0.8711589214830474 0.9933009363537146 1.0383330930125798 1.3301227626694856 1.5824266896483918 1.459174276772895 1.4658168772812827 1.0 13.859919141956283 -6.691125075884576 2.3042142380650965 1.4218225914871656 0.9079303305561809 0.6637426339623957 0.15252661173372314 0.15976073799097693 1.7370323448245382 0.05536135032827819 0.053433848885363566 2.036455498402549e-07 6.691125075884576 -0.5138922609309847 ILS(ph)PSMASK ddPTM_A459_Selumetinib_30min_R2 3 ILSPSMASK 9 0 A0A494BZT8;Q9Y6A5;E7EMT0;C9JA91;Q8IX09;C9JWI7 A0A494BZT8 TACC3;ERIC-1s Transforming acidic coiled-coil-containing protein 3 1 ILS(0.955)PS(0.045)MASK;ILS(0.979)PS(0.02)MAS(0.001)K;ILS(0.967)PS(0.031)MAS(0.002)K 105.13 0.013923 58722200.0 319076.0 324066.0 363316.0 384932.0 394503.0 286202.0 294127.0 303880.0 270432.0 371257.0 True False 301343.0332824307 348920.82016357465 339940.6441085516 332503.5975552624 344942.0062384327 325623.7276169184 307804.4883015941 304764.2404899582 324525.95650141244 360537.8457684711 0.83581525994901 0.9677786236833605 0.9428709027313973 0.9222432581149563 0.9567428504023024 0.903161017459527 0.853736970790187 0.845304436321702 0.9001162022524963 1.0 18.459791181993637 -6.993240768835553 23.77076786265877 0.885691087923726 0.9284574778427803 0.024248284751558158 0.052059501754553685 189.87096335693687 667726.562601374 0.01758551583386458 0.01546719150937541 1.0156854501570625e-07 6.993240768835553 0.04276638991905435 ILSDVT(ph)HSAVFGVPASK ddPTM_A459_Selumetinib_30min_R1 3 ILSDVTHSAVFGVPASK 17 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 ILS(0.229)DVT(0.771)HSAVFGVPASK;ILS(0.228)DVT(0.772)HSAVFGVPASK;ILS(0.287)DVT(0.713)HSAVFGVPASK 154.72 9.6807e-05 613112400.0 36599.9 42838.7 38503.5 40787.5 36013.700000000004 35848.5 37865.8 35806.899999999994 21836.7 31499.5 True False 37452.606458991824 37823.12508882869 33274.936184586295 33664.7288011998 32756.267193735144 35487.896637833735 35009.552220069505 34857.184694796895 37055.28501053436 35542.76765611288 1.0537335421190948 1.0641581278863526 0.9361942915231434 0.9471611532032711 0.9216014777088273 0.9984561973673508 0.984997920218189 0.9807110417525947 1.0425548558585966 1.0 15.117268405549842 -10.58671098655601 18.02779782849544 0.9999999999973218 0.9888820172694335 0.0 0.04687195390509407 0.0 0.0 0.04898936199682613 0.011881665532031405 2.589935887267646e-11 10.58671098655601 -0.011117982727888331 ILSDVT(ph)HSAVFGVPASK ddPTM_A459_Selumetinib_30min_R2 2 ILSDVTHSAVFGVPASK 17 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 ILS(0.021)DVT(0.916)HS(0.063)AVFGVPASK;ILS(0.443)DVT(0.552)HS(0.005)AVFGVPASK 88.176 0.01386 107526320.0 158818.0 134804.0 162257.0 172990.0 185308.0 140555.0 155914.0 166330.0 141263.0 160233.0 True False 149991.531358827 145143.03333682235 151817.5612720638 149428.4635756052 162027.95236546107 159915.17541874605 163164.3099377297 166813.99276258613 169519.54721800302 155606.65695466872 0.9639146183991503 0.9327559384500199 0.9756495271040443 0.9602960856561338 1.0412661998944106 1.0276885227688715 1.0485689566948455 1.0720234983981587 1.089410636637399 1.0 17.247544255519614 -6.306127210477528 1.3362208237167028 1.0562583735680804 0.9499996657455709 0.7365375489872081 0.02554005420421803 0.20469203085785062 0.741560434590908 0.009843408902189179 0.013359887524360022 4.941659181890378e-07 6.306127210477528 -0.10625870782250946 ILSEVT(ph)PDQSKPEN ddPTM_A459_Selumetinib_30min_R2 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 ILS(0.001)EVT(0.999)PDQSKPEN 153.32 0.00082292 0.0 21028.0 20807.0 20238.0 24240.0 25461.0 16335.0 20014.0 19112.0 17969.0 21320.0 True False 19859.347941753527 22402.82999495012 18935.90911346833 20938.47018366765 22262.361555772 18584.997975633865 20944.69065698864 19167.612755838087 21563.30209580919 20704.43620398752 0.9591832275021701 1.0820304293355016 0.914582214502485 1.0113035668962123 1.0752459683729247 0.8976336178646842 1.011604008466304 0.9257732288381051 1.0414822158575012 1.0 14.337652297215671 -6.7537314618947555 24.99999203190308 0.9729285262542113 1.0074973337375626 0.07029099203384792 0.059956853090736235 504.2561830500924 1635510.9348445847 0.01907765174618053 0.018730981099736182 1.763065869200325e-07 6.7537314618947555 0.03456880748335123 ILSLQASPT(ph)QK ddPTM_A459_Selumetinib_30min_R2 1 ILSLQASPTQK 11 0 J3KTH2;Q92750-2;Q92750 J3KTH2 TAF4B Transcription initiation factor TFIID subunit 4B 1 ILSLQAS(0.121)PT(0.879)QK 111.72 0.011982 0.0 23445.0 20295.0 20887.0 29539.0 23728.0 21477.0 20869.0 21012.0 16772.0 25136.0 True False 22142.02075777114 21851.56124128961 19543.15316004611 25515.73724238278 20747.076508988586 24435.26180120531 21839.449851139 21073.14144127614 20126.86864883474 24410.258368828803 0.9070785086832945 0.8951794328073736 0.800612302612993 1.0452874712283111 0.849932687950653 1.0010243001937429 0.8946832729565595 0.8632903889368879 0.8245250150459764 1.0 14.575199944863328 ILSQS(ph)TDSLNMR ddPTM_A459_Selumetinib_30min_R1 2 ILSQSTDSLNMR 12 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 ILSQS(0.717)T(0.061)DS(0.222)LNMR;ILSQS(0.916)T(0.078)DS(0.007)LNMR 228.17 7.710599999999999e-10 81995000.0 2441.0 3054.2 2913.7 3312.8999999999996 3169.9 2680.8 2968.9 2214.04 1704.3899999999999 2279.6 True False 2497.87055064082 2696.612844140941 2518.0355438084603 2734.364205834997 2883.1831046913 2653.833585971649 2744.9534827248963 2155.3164669845214 2892.225346279642 2572.208865184364 0.9710994252645125 1.0483646490144805 0.9789389881556056 1.0630412805295304 1.1208977403491869 1.031733317574673 1.06715808341954 0.8379243599372472 1.1244131009059175 1.0 11.328792079945098 -9.89827405720361 7.253397671313275 1.0000000260389708 1.0258462133630812 0.010164482038470424 0.07930588077239223 0.0 0.0 0.07472437736097215 0.018123323568694196 1.2639384999697348e-10 9.89827405720361 0.02584618732411048 ILSQS(ph)TDSLNMR ddPTM_A459_Selumetinib_30min_R2 2 ILSQSTDSLNMR 12 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 ILS(0.002)QS(0.81)T(0.074)DS(0.114)LNMR;ILSQS(0.919)T(0.081)DSLNMR 262.48 2.5531e-25 30411000.0 55355.0 57669.0 53363.0 64550.0 55645.0 50917.0 56477.0 55766.0 50033.0 55127.0 True False 52278.59070362216 62092.0268649387 49929.682677241384 55758.17864503908 48654.37762738834 57930.35457149371 59103.29240705246 55928.26982744175 60040.998038823534 53535.34027285276 0.9765248607214349 1.1598324872593544 0.932649020679901 1.041520953464706 0.9088272789415798 1.082095570444513 1.1040051694043898 1.044698129168377 1.1215208072427203 1.0 15.708203951516458 ILTFDQLALDSPK ddPTM_A459_Selumetinib_30min_R1 2 ILTFDQLALDSPK 13 0 F8VUA6;H0YHA7;J3QQ67;Q07020-2;Q07020;G3V203 F8VUA6 RPL18 60S ribosomal protein L18 0 ; 134.18 0.01728 7682700.0 3485.0 3321.3 4466.5 4201.8 3514.7 3573.7000000000003 3690.2 3575.8 2361.8 3061.9 False True 3566.1937193704453 2932.4406519695194 3859.9738327283135 3468.034507554554 3196.7960055706853 3537.7518226599827 3411.8452430029347 3480.958168164646 4007.8021009529843 3454.9246904316583 1.0322059202178688 0.848771222160313 1.1172381972372452 1.0037945305028508 0.9252867405255302 1.0239736433207105 0.987531002470754 1.0075351795091472 1.1600258934883612 1.0 11.75443854811935 -8.030445588089862 20.79458377347542 1.0812692479357664 0.9903761852044862 0.17888789960753437 0.07500435609210501 139.8007520328441 95480.28605922878 0.04791632568790311 0.018221561140913126 9.322972687345056e-09 8.030445588089862 -0.09089306273128017 ILTT(ph)NTWSSELSK ddPTM_A459_Selumetinib_30min_R2 1 ILTTNTWSSELSK 13 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 1 ILT(0.004)T(0.943)NT(0.052)WSSELSK 154.13 0.00026056 0.0 17852.0 17164.0 20047.0 19602.0 24515.0 13823.0 15006.0 18332.0 13571.0 18781.0 True False 16859.857307218183 18480.423609041376 18757.197845523253 16932.173784663908 21435.206533119326 15726.992777299482 15703.808733824902 18385.34308497402 16285.579205421913 18238.743731101767 0.9243979495401196 1.0132509059561752 1.0284259772528843 0.9283629417847556 1.1752567418646693 0.8622848705572247 0.8610137279930006 1.0080377988765896 0.892911235857259 1.0 14.154718740887258 ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR ddPTM_A459_Selumetinib_30min_R1 3 ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR 36 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 ;; 140.73 5.505100000000001e-35 93143500.0 1774.8799999999999 2575.9 1599.0040000000001 1985.26 1742.35 1687.824 1880.2199999999998 2073.59 840.53 1572.89 False True 1816.2312506847118 2274.312430496579 1381.8680395002582 1638.5716089456325 1584.7547501368765 1670.8460229815769 1738.393491626194 2018.5916572304186 1426.3180201177117 1774.7857527460233 1.0233523950001076 1.281457453091263 0.7786111858077369 0.9232503734100669 0.8929273562653279 0.941435336854814 0.9794948426515585 1.1373720203169135 0.8036564514397596 1.0 10.79342916161375 -5.256619762612707 24.999958736106848 0.9373115227758739 1.1524049152322526 0.38390940835456366 0.11147949509622475 406.319149545989 2107611.7005978813 0.02792891825367399 0.06912754674197988 5.538347953976136e-06 5.256619762612707 0.2150933924563787 ILVSIGESFGT(ph)SEK ddPTM_A459_Selumetinib_30min_R1 2 ILVSIGESFGTSEK 14 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 ILVSIGES(0.003)FGT(0.975)S(0.022)EK;ILVSIGES(0.029)FGT(0.936)S(0.035)EK 250.46 4.0539e-27 22393000.0 4230.200000000001 6181.7 5614.700000000001 6052.2 4310.6 5217.9 4721.6 3886.1 3195.6000000000004 3759.6 True False 4328.755429463666 5457.9436902056395 4852.254579339455 4995.296883864455 3920.706991098243 5165.412663474134 4365.445910618032 3783.028004168194 5422.699802610451 4242.181281605167 1.0204079321725121 1.2865889805021367 1.1438112275822985 1.1775302732876898 0.9242195773431721 1.2176312893256727 1.0290568980508592 0.8917648146183801 1.2782810169202852 1.0 12.050590557695717 IMAT(ph)PEQVGK ddPTM_A459_Selumetinib_30min_R1 2 IMATPEQVGK 10 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 IMAT(1)PEQVGK;IMAT(1)PEQVGK 117.95 0.013715 49391000.0 13163.8 14628.0 16281.400000000001 16609.8 13838.5 13092.6 14539.6 12243.3 7827.0 11539.1 True False 13470.490927704077 12915.3469596273 14070.475307328516 13709.210234561297 12586.810118385609 12960.90033112966 13442.866266100886 11918.567912156777 13281.847338537984 13020.255885352206 1.034579584788221 0.9919426371763609 1.0806604287368735 1.0529140406513948 0.9667098887469466 0.995441291266071 1.0324579166853485 0.9153866112236068 1.0200911146055178 1.0 13.668470181424816 -6.257087366343755 24.862058459726093 0.9866773140847821 1.0394923683473178 0.3277710174842765 0.036204658872115665 423.62111165029995 2420051.0302937734 0.010799726263755815 0.013464616549051373 5.532388038330124e-07 6.257087366343755 0.05281505426253574 IMAT(ph)PEQVGK ddPTM_A459_Selumetinib_30min_R2 3 IMATPEQVGK 10 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 IMAT(1)PEQVGK;IMAT(1)PEQVGK;IMAT(1)PEQVGK 126.34 0.0081206 58637000.0 507870.0 443097.0 490070.0 547290.0 536560.0 376141.0 411095.0 429210.0 396046.0 455589.0 True False 479644.61856469285 477081.1151185849 458539.42974787275 472748.1578720908 469152.535892739 427951.0084819655 430211.7320692885 430458.9300404596 475266.26644982235 442434.96180762025 1.084101981012188 1.078307901277543 1.0363996278107312 1.0685144680714707 1.0603875742006486 0.967263090451806 0.9723728213331236 0.9729315429363197 1.0742059454525608 1.0 18.755105868222664 -6.721072987394518 10.486678678025692 0.9941202909552903 1.064872653742208 0.5494948163408395 0.03079850575303067 0.3775254345896897 95.80294136352774 0.010325770423194791 0.010293745153730832 1.9007588121489666e-07 6.721072987394518 0.07075236278691766 IMDPNIVGSEHYDVAR ddPTM_A459_Selumetinib_30min_R1 4 IMDPNIVGSEHYDVAR 16 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 ;;; 156.72 0.0016338 27008800.0 10289.9 15705.5 13115.400000000001 14936.4 14108.7 14095.2 14074.199999999999 11920.8 4600.48 9602.5 False True 10529.634649340016 13866.692758711133 11334.400717735354 12328.038130952898 12832.5705760933 13953.415085417637 13012.57176279657 11604.621659784414 7806.678554234983 10835.074411270774 0.9718100909751911 1.27979672611079 1.046084252632836 1.1377898907763038 1.1843546328343353 1.2878005776225336 1.2009674570633992 1.07102371606356 0.7205006867432661 1.0 13.403421440909296 -8.063941229411508 5.436072937224124 0.8639323293594572 1.1625086474426816 0.5325061796924672 0.11015048309419967 0.15736260366669755 9.132158906908952 0.07283412623029982 0.027130198076129205 8.630953376205105e-09 8.063941229411508 0.2985763180832244 IMDPNIVGSEHYDVAR ddPTM_A459_Selumetinib_30min_R2 1 IMDPNIVGSEHYDVAR 16 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 116.04 0.0027431 1959400.0 11486.0 10322.0 14331.0 15266.0 11150.0 10215.0 16495.0 12058.0 13521.0 10698.0 False True 10847.654102101062 11113.664209538869 13408.959062413025 13186.744464681125 9749.237317735284 11622.023527462507 17262.050184222422 12093.086783690636 16225.577808305197 10389.120943257898 1.0441358957458988 1.0697405748030269 1.290673112349787 1.2692839496915056 0.9384082995070077 1.1186724642959047 1.661550604570136 1.1640144387325224 1.5617854385298031 1.0 13.342785967915283 IMEETS(ph)GMEEEEEEESIAAVPGRR ddPTM_A459_Selumetinib_30min_R1 1 IMEETSGMEEEEEEESIAAVPGRR 24 1 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 IMEET(0.252)S(0.748)GMEEEEEEESIAAVPGRR 59.687 0.004756300000000001 2496400.0 229.71 213.85 232.24 221.05 224.32 250.54 220.94 225.57 166.75 134.47 True False 235.06179606214792 188.8123425838322 200.7030836030055 182.44776712240815 204.0302956069126 248.01979507211917 204.27431792018547 219.58715084537704 282.962571061864 151.7305343487197 1.549205616859619 1.2443925238534257 1.32276001310147 1.2024459539771446 1.3446884404822121 1.634607009964781 1.3462967015637426 1.4472179366395932 1.8649019610748618 1.0 7.245367633439275 -6.5514457768018435 24.14872217149068 1.4806601855433985 1.316918656220433 0.0692102125321643 0.22223926376508168 324.0162121339579 273899.4761725836 0.06970577212910023 0.06970728889383765 2.8090160664402476e-07 6.5514457768018435 -0.1637415293229656 IMNT(ph)FSVVPSPK ddPTM_A459_Selumetinib_30min_R1 1 IMNTFSVVPSPK 12 0 P04350;M0R2D3;M0QYM7;M0R042;P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;G3V2A3 P04350;P68371;P07437;A0A0B4J269 TUBB4A;TUBB4B;TUBB;TUBB3 Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain 1 IMNT(0.969)FS(0.031)VVPSPK 121.24 0.0089701 10556000.0 1796.7 2130.3 2403.8 3131.9 2099.3 2264.0 2104.5 1963.5 961.03 1357.2 True False 1838.5596142303827 1880.8834856503984 2077.37716312825 2584.972458044197 1909.4186856615183 2241.2262155475278 1945.755870657329 1911.4216016531361 1630.7977191459252 1531.4098402475076 1.2005666712532246 1.2282038656264664 1.356512873648835 1.6879690792808357 1.2468371532423461 1.4635051680125675 1.2705650829191841 1.248145043487647 1.0648995953182294 1.0 10.580644717314483 -8.139409673248867 1.4455006372203345 0.9979992874242207 1.3652700899809016 0.4766717268334387 0.13372872565297228 0.3690521463709051 1.406950886849523 0.1288834967505172 0.04103161046902129 7.254213391817483e-09 8.139409673248867 0.3672708025566809 IMNTFS(ph)VVPSPK ddPTM_A459_Selumetinib_30min_R2 2 IMNTFSVVPSPK 12 0 P04350;M0R2D3;M0QYM7;M0R042;P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;G3V2A3 P04350;P68371;P07437;A0A0B4J269 TUBB4A;TUBB4B;TUBB;TUBB3 Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain 1 IMNT(0.002)FS(0.984)VVPS(0.014)PK;IMNTFS(0.853)VVPS(0.146)PK 131.86 0.0019656 15429400.0 85009.0 75840.0 81769.0 81961.0 69595.0 57822.0 65244.0 69931.0 64198.0 65917.0 True False 80284.5400979897 81656.68413596474 76508.07156335576 70797.77040938892 60851.85391280593 65786.45564414456 68277.97527853335 70134.48763229967 77039.39384199222 64013.80493706591 1.2541754107089882 1.27561053769955 1.1951808151159484 1.105976601125219 0.950605169816595 1.0276916941403718 1.0666132929554757 1.0956150427435334 1.2034809353659293 1.0 15.966095443514552 -5.691882177605289 2.6039586515798847 1.0593203048317175 1.2612092383481348 0.6394815367878823 0.06298327489223676 0.18278196866500382 2.508609526085236 0.01956694683882505 0.03753928990510256 2.0329084562452218e-06 5.691882177605289 0.20188893351641735 IMPDS(ph)NDSPPAEREPGEVVDSLVGK ddPTM_A459_Selumetinib_30min_R2 1 IMPDSNDSPPAEREPGEVVDSLVGK 25 1 Q9Y657 Q9Y657 SPIN1 Spindlin-1 1 IMPDS(0.597)NDS(0.402)PPAEREPGEVVDS(0.001)LVGK 46.839 0.03127 2977800.0 15631.0 11522.0 12378.0 14807.0 13291.0 10113.0 8709.3 11374.0 7217.6 10784.0 True False 14762.291595850751 12405.700350930716 11581.612956147399 12790.261056500281 11621.265756952429 11505.973953326313 9114.299707150545 11407.096456932939 8661.321676593712 10472.63789980307 1.4096058449732463 1.1845821911940635 1.1058926191237053 1.2213027108232961 1.1096789431792498 1.098670083259794 0.8702964615363941 1.0892285750801562 0.8270429818600509 1.0 13.354337260750992 -1.5228787452826011 0.25061999294535287 0.92175302119942 3.75173654549686 0.6682188678414679 0.09189738302571426 30.40114778547149 0.4137817155885212 0.11641111139076066 36.29694023892224 0.029999999999843638 1.5228787452826011 2.8299835242974396 IMPDSNDS(ph)PPAEREPGEVVDSLVGK ddPTM_A459_Selumetinib_30min_R1 1 IMPDSNDSPPAEREPGEVVDSLVGK 25 1 Q9Y657 Q9Y657 SPIN1 Spindlin-1 1 IMPDS(0.108)NDS(0.892)PPAEREPGEVVDSLVGK 79.237 0.00012169 10414000.0 868.26 990.18 1336.3 1458.1 660.94 898.36 999.55 809.94 460.47 578.29 True False 888.4887686601388 874.2492652778067 1154.8377997704797 1203.470206926864 601.158093698435 889.3233140456172 924.1531387576783 788.4577601441002 781.3839586018382 652.519154521612 1.3616286395631185 1.3398062864817415 1.7698144058577678 1.844344642739532 0.9212880411750796 1.3629075987778716 1.4162850735549857 1.2083289121560734 1.19748815523232 1.0 9.349876441997845 -6.259009383663504 24.998014594580212 1.2153207503754204 1.5754573185535325 0.47486466822812046 0.20166382566870603 227.49696236903824 2340319.68862571 0.06434802003959676 0.07919365670180237 5.507957954062971e-07 6.259009383663504 0.3601365681781121 IMPDSNDS(ph)PPAEREPGEVVDSLVGK ddPTM_A459_Selumetinib_30min_R2 1 IMPDSNDSPPAEREPGEVVDSLVGK 25 1 Q9Y657 Q9Y657 SPIN1 Spindlin-1 1 IMPDS(0.289)NDS(0.697)PPAEREPGEVVDS(0.014)LVGK 68.569 0.00084781 2860100.0 7160.0 9869.8 8807.3 9532.7 9677.1 7070.3 7378.6 6346.3 7454.2 7506.0 True False 6762.075863750961 10626.781923591047 8240.64790666319 8234.329815175272 8461.376183628352 8044.169647206865 7721.719520418522 6364.766682313479 8945.248287750057 7289.282277069907 0.9276737553466143 1.4578639596685674 1.1305156795184101 1.1296489149663234 1.1607968880894532 1.1035612755060438 1.0593250785072412 0.8731678154837409 1.2271781977615777 1.0 12.83156105445611 -6.950025234911445 1.712594398436162 1.0286588688079923 1.179417879375301 0.12923678975164155 0.1451868360200531 0.6523370947445071 3.8930592527401613 0.06437283798084358 0.05073294651083103 1.1219532607180503e-07 6.950025234911445 0.15075901056730867 IMS(ph)CSPDTQCSR ddPTM_A459_Selumetinib_30min_R2 1 IMSCSPDTQCSR 12 0 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 IMS(0.975)CS(0.025)PDTQCSR 195.72 0.00016892 57614000.0 75939.0 68959.0 85602.0 85700.0 95312.0 71436.0 58676.0 65192.0 58710.0 67207.0 True False 71718.61438790277 74247.93356186691 80094.46051641052 74027.51215925397 83338.05445990898 81275.6605685572 61404.55026428826 65381.69792688338 70453.64049446033 65266.55928524345 1.0988569824013705 1.1376106596545241 1.2271898717130567 1.134233410952787 1.2768875113468934 1.2452879615324437 0.9408271392999817 1.001764129178876 1.0794753280396943 1.0 15.994056365029467 -7.259998946741057 24.995632070381745 1.0056636576244788 1.1880054857286464 0.6875215181439237 0.059828484768144286 79.5034748991472 1379628.6817742984 0.025048181392889068 0.018327445107058988 5.4954220661584766e-08 7.259998946741057 0.18234182810416755 IMS(ph)SIGEGIDFSQER ddPTM_A459_Selumetinib_30min_R1 1 IMSSIGEGIDFSQER 15 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 IMS(0.629)S(0.371)IGEGIDFSQER 186.29 2.2303000000000007e-05 5428500.0 1176.5 1577.6 1298.9 1474.5 1563.9 1380.0 1459.6 1151.0 814.86 1139.0 True False 1203.9101609295076 1392.8938585936567 1122.5165143469853 1217.0062547929913 1422.445521128971 1366.1184529397478 1349.501196869298 1120.4717410250873 1382.7579049803333 1285.2017447995215 0.936747997581738 1.0837939368117915 0.87341658139601 0.9469379105012279 1.1067877295411377 1.0629603161275263 1.0500306292999988 0.8718255678993571 1.0759072733721113 1.0 10.32777912919898 IMSCS(ph)PDTQCSR ddPTM_A459_Selumetinib_30min_R1 3 IMSCSPDTQCSR 12 0 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 IMS(0.143)CS(0.842)PDT(0.015)QCSR;IMS(0.063)CS(0.935)PDT(0.002)QCSR;IMS(0.123)CS(0.737)PDT(0.14)QCSR 165.51 0.00045796 69177000.0 6293.5 7404.900000000001 7867.400000000001 8209.9 8303.400000000001 5709.7 6716.3 6294.800000000001 3221.09 5443.99 True False 6440.126304980746 6537.930865555389 6799.050292534813 6776.195083909785 7552.358936084335 5652.265601992811 6209.684083675851 6127.841455607925 5465.954470894513 6142.779145453163 1.0484059661737435 1.0643278409894834 1.1068361944230758 1.1031155318233232 1.229469391175252 0.920147944139677 1.0108916398650292 0.997568252171935 0.8898178400147057 1.0 12.584675798928064 -6.7823769595713985 24.999798966826056 0.9664835408553488 1.1072636186284268 0.6242898589847532 0.056873290481394216 171.80847547845653 205140.5994739013 0.020403942571747172 0.018012929237646635 1.6505285480736413e-07 6.7823769595713985 0.140780077773078 IMSCS(ph)PDTQCSR ddPTM_A459_Selumetinib_30min_R2 1 IMSCSPDTQCSR 12 0 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 IMS(0.204)CS(0.796)PDTQCSR 197.38 0.00014286 60766000.0 65085.0 63294.0 73683.0 74572.0 83932.0 62274.0 60459.0 64839.0 47527.0 74350.0 True False 61467.83625589822 68148.44627771292 68942.3159999845 64415.16495612477 73387.7117983998 70851.67823291241 63270.46329723576 65027.67075532568 57033.72801533323 72203.32231550054 0.8513158991120602 0.9438408662129233 0.9548357857929762 0.8921357479182946 1.016403531650856 0.9812800292390707 0.8762818838275661 0.9006188173887616 0.7899044834269252 1.0 16.139777601396275 -10.65012642466819 4.784249459873674 1.0000055270866046 0.9172131704625613 0.14662374045861992 0.0626077931091703 3.8105941240366366e-06 6.951619145573732e-07 0.06258486859714432 0.015178046973186633 2.2380695337300432e-11 10.65012642466819 -0.08279235662404327 IMSS(ph)IGEGIDFSQER ddPTM_A459_Selumetinib_30min_R1 1 IMSSIGEGIDFSQER 15 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 IMS(0.048)S(0.952)IGEGIDFSQER 121.18 0.0017047999999999998 5090000.0 3201.0 3598.5 3935.9 4158.7 3312.4 3585.4 3308.6 3216.3 1948.0 3080.0 True False 3275.5770719382504 3177.185947102736 3401.42639835114 3432.461113467353 3012.79400485172 3549.3341312827324 3059.029638230857 3130.9932759852195 3305.6137237092107 3475.348001740587 0.9425177191745162 0.9142065616195788 0.9787297262454223 0.9876596852310172 0.8669042649377264 1.0212888405722507 0.8802081508668422 0.9009150376932321 0.9511604944464938 1.0 11.762941733073133 IMSS(ph)PLSK ddPTM_A459_Selumetinib_30min_R2 1 IMSSPLSK 8 0 J3KSS0;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;P61254;E5RHH1;E5RIT6;Q9UNX3 J3KSS0 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 1 IMS(0.307)S(0.674)PLS(0.019)K 93.561 0.02389 12267000.0 53664.0 45711.0 55580.0 57456.0 53601.0 38858.0 40418.0 43313.0 39493.0 58649.0 True False 50681.56971401282 49216.88671596892 52004.04331092848 49630.39368287166 46867.16318098018 44210.33678219657 42297.51708674762 43439.033659146844 47392.703526617646 56955.65098159775 0.8898426905942648 0.864126489079561 0.9130620476575867 0.8713866460574234 0.8228711703448506 0.7762238868357565 0.7426395161458844 0.7626817165724592 0.8320983556474516 1.0 15.79755136878174 -6.282563073780775 3.1343073150374137 0.8028191323469975 0.8869798491962599 0.13415347091603147 0.06857318133473127 0.36995939025857116 7.4506268719186455 0.02106503651264585 0.02581285582863569 5.217193280051773e-07 6.282563073780775 0.0841607168492624 IMVGS(ph)TDDPSVFSLPDSK ddPTM_A459_Selumetinib_30min_R1 1 IMVGSTDDPSVFSLPDSK 18 0 O43741 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 IMVGS(0.771)T(0.192)DDPS(0.036)VFSLPDSK 135.09 0.00036259 26025000.0 4665.7 4902.4 4876.5 5333.7 5452.3 4346.6 5312.0 4791.7 2595.1 4813.5 True False 4774.401732128176 4328.424728936074 4214.298084697109 4402.269420949055 4959.140427681749 4302.877150397032 4911.311563284266 4664.608550364822 4403.695161395164 5431.359612460495 0.8790435678710831 0.796932082899815 0.7759195460062647 0.8105280694081596 0.9130569105210063 0.7922283659004045 0.9042508531412381 0.8588288905900079 0.8107905709819532 1.0 12.407097672493833 -14.522878745280323 0.2270816920634446 1.8538365825287886 0.8190471364194717 0.5209736041047153 0.04637961760379485 127.6474765836351 1.2745382988702634 50.0465762001274 0.0828369167128506 3.0000000000000992e-15 14.522878745280323 -1.034789446109317 IMVGS(ph)TDDPSVFSLPDSK ddPTM_A459_Selumetinib_30min_R2 2 IMVGSTDDPSVFSLPDSK 18 0 O43741 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 IMVGS(0.917)T(0.082)DDPS(0.001)VFSLPDSK;IMVGS(0.871)T(0.129)DDPSVFSLPDSK 111.06 0.0023118 2814100.0 27537.0 21098.4 27207.0 24559.0 29615.0 19472.3 18625.7 26007.0 15764.5 21453.1 True False 26006.603779345012 22716.579437951455 25456.53124074183 21214.021833361956 25894.498938540848 22154.432573060018 19491.83195612438 26082.676064309362 18917.840496932713 20833.693261152188 1.248295415188749 1.090376975085364 1.221892389488602 1.0182554560750374 1.2429144757941386 1.0633943917361288 0.9355917701097228 1.251946821783383 0.9080406560563175 1.0 14.346630993159522 -1.522878745280495 0.13262233098362705 0.9529614137376261 1.8067834340918185 0.2557305230214918 0.1099127260747717 121.4204895854732 1.0893683293122751 0.529901858528232 19.443977350116388 0.029999999999989122 1.522878745280495 0.8538220203541924 IMVGST(ph)DDPSVFSLPDSK ddPTM_A459_Selumetinib_30min_R1 1 IMVGSTDDPSVFSLPDSK 18 0 O43741 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 IMVGS(0.297)T(0.702)DDPS(0.001)VFSLPDSK 168.55 2.6268e-07 23448000.0 5928.8 7441.9 6961.5 7813.6 7603.6 7018.3 7912.3 7385.5 3946.0 6828.0 True False 6066.929504563415 6570.598888354554 6016.1665367823025 6449.10143943745 6915.855722524615 6947.702274106541 7315.468840770723 7189.612548515016 6696.073795562911 7704.440310352182 0.7874588237657573 0.8528327332909407 0.7808700300654668 0.8370629376895843 0.8976454413219382 0.9017789734539394 0.9495133385537672 0.9331777856536302 0.8691187842114417 1.0 12.911474440518607 -6.348723525158944 1.7146464300350737 0.9294264953831344 0.8097695002400593 0.7053508567952114 0.0359766151981462 0.20611102203015935 1.2020613964830331 0.012700783808563626 0.01584341422979567 4.479984122728193e-07 6.348723525158944 -0.11965699514307504 IMVGST(ph)DDPSVFSLPDSK ddPTM_A459_Selumetinib_30min_R2 1 IMVGSTDDPSVFSLPDSK 18 0 O43741 O43741 PRKAB2 5-AMP-activated protein kinase subunit beta-2 1 IMVGS(0.45)T(0.548)DDPS(0.002)VFSLPDSK 118.53 0.0023274000000000003 10789000.0 13758.0 8525.0 14440.0 14377.0 11538.0 8932.1 8818.2 13355.0 7313.6 10760.0 True False 12993.385437637671 9178.840087804574 13510.946121083258 12418.827798291662 10088.493288971273 10162.415697469198 9228.263772931812 13393.860838960733 8776.524359057817 10449.33084216256 1.2434657906714917 0.8784141517242793 1.2929963004489458 1.188480677459486 0.9654678793655068 0.9725422470560819 0.8831439938427635 1.2817912497245403 0.8399125735061381 1.0 13.35112293701312 -6.264896587096712 24.826541471791703 0.9983025640066474 1.141534373135085 0.21313240802995514 0.1500753993891064 498.0952328877731 3576861.2119404296 0.04487398100759659 0.05292076310464513 5.433797040390874e-07 6.264896587096712 0.1432318091284377 IMVQSAS(ph)PDIR ddPTM_A459_Selumetinib_30min_R2 1 IMVQSASPDIR 11 0 Q9NQT8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 IMVQS(0.067)AS(0.933)PDIR 114.87 0.0063424 3264700.0 34596.0 28027.0 29159.0 29848.0 29978.0 23171.0 24366.0 20899.0 19855.0 20656.0 True False 32673.29281876092 30176.580778991087 27282.94168591873 25782.650909328055 26211.895633279662 26362.594924604386 25499.06728031303 20959.81262998431 23826.5547950521 20059.60760926671 1.6288101669380217 1.5043455169606983 1.3600934882352902 1.285301856922542 1.306700317566075 1.3142128918028264 1.2711648092524759 1.0448765019860977 1.1877876805548886 1.0 14.292005764876324 -1.5228787452826837 0.17174697968062883 0.9745898085452369 3.5729536087850153 0.8795965920818344 0.06221936412898 20.167858044544854 0.21989191743389264 0.167460121331404 13.498308530199118 0.02999999999983793 1.5228787452826837 2.5983638002397784 INAWNS(ph)PTLPIYEPGLK ddPTM_A459_Selumetinib_30min_R1 2 INAWNSPTLPIYEPGLK 17 0 O60701;O60701-2;E7ER83;E7ETF4;E7EV97;E7ER95 O60701 UGDH UDP-glucose 6-dehydrogenase 1 INAWNS(0.808)PT(0.192)LPIYEPGLK;INAWNS(0.981)PT(0.018)LPIYEPGLK 196.71 8.533e-08 8244200.0 3269.87 3534.2200000000003 4405.84 3922.69 3864.2 3412.04 3706.43 4030.6099999999997 2395.69 3254.7 True False 3346.0516089405587 3120.4318793856996 3807.551127546785 3237.665829510966 3514.683792279919 3377.717975484447 3426.851001036086 3923.7051295335605 4065.3109557253183 3672.472448462689 0.9111168717797267 0.849681494735767 1.03678140026364 0.8816038445342905 0.9570347610779706 0.9197395005368584 0.9331182327781871 1.068409684373817 1.106968401472167 1.0 11.84253595213109 -7.7539589919770116 7.6144143088985725 1.0661695771966078 0.9271855796838098 0.5688686539119878 0.052318902487413194 0.08555165165462389 31.56004961843749 0.02528278570287356 0.013555595552474316 1.7621424279077377e-08 7.7539589919770116 -0.138983997512798 INAWNS(ph)PTLPIYEPGLK ddPTM_A459_Selumetinib_30min_R2 1 INAWNSPTLPIYEPGLK 17 0 O60701;O60701-2;E7ER83;E7ETF4;E7EV97;E7ER95 O60701 UGDH UDP-glucose 6-dehydrogenase 1 INAWNS(0.486)PT(0.486)LPIY(0.029)EPGLK 99.915 0.004596500000000001 3380700.0 27388.0 19378.0 19883.0 17986.0 23159.0 16966.0 16194.0 20172.0 14977.0 19145.0 True False 25865.88460285075 20864.230289909327 18603.74942697356 15536.275772419403 20249.559375913133 19302.912497986174 16947.053087802233 20230.69718034563 17972.81849234427 18592.234105316184 1.391219820938828 1.12220135416343 1.0006193619116535 0.8356325379948302 1.089140727317061 1.0382244752644751 0.9115124622358571 1.088126207197496 0.9666841752603148 1.0 14.182412519306656 -4.805162294300417 2.247843544454031 0.9916755296384399 1.4803257248283581 0.7381351292998639 0.07263277915566879 0.2955332540054046 1.8458006238075861 0.019295184574599503 0.2865037501555866 1.5661656901998737e-05 4.805162294300417 0.48865019518991826 INAWNSPT(ph)LPIYEPGLK ddPTM_A459_Selumetinib_30min_R2 1 INAWNSPTLPIYEPGLK 17 0 O60701;O60701-2;E7ER83;E7ETF4;E7EV97;E7ER95 O60701 UGDH UDP-glucose 6-dehydrogenase 1 INAWNS(0.169)PT(0.831)LPIY(0.001)EPGLK 107.98 0.005587 3592500.0 53203.0 41004.0 39923.0 51637.0 48907.0 36946.0 39912.0 39647.0 32846.0 40480.0 True False 50246.19024848357 44148.87495135943 37354.39764487582 44603.951521206516 42762.86542587261 42034.976137604484 41767.98708412763 39762.366206085826 39416.11779391997 39311.23722032902 1.2781635430822755 1.1230599206002279 0.9502218776660313 1.1346361670382756 1.0878025839328875 1.069286522375514 1.062494849755788 1.0114758277188873 1.0026679540255403 1.0 15.262654149150805 -4.855303214601677 3.44529988430483 1.0465484259892284 1.2898257533334667 0.6737188389867088 0.05040433231946684 0.15709369742232346 3.1096787944270465 0.012942165788636132 0.0892910193883724 1.3953937884456172e-05 4.855303214601677 0.24327732734423835 INEELESQYQQSMDSK ddPTM_A459_Selumetinib_30min_R1 1 INEELESQYQQSMDSK 16 0 O00193;E9PM92;E9PRZ9 O00193 SMAP;C11orf58 Small acidic protein 0 131.08 0.018476 0.0 699.51 535.9 553.02 635.17 532.28 712.34 450.17 430.48 374.39 530.5 False True 715.8072219904798 473.15657886684886 477.9229215214178 524.2494831175752 484.1353679816664 705.1745063529705 416.21331446605393 419.0622720038922 635.3124856362896 598.5948425075917 1.1958125449124657 0.7904454653914731 0.7984080175487922 0.8758002005520561 0.8087864004199574 1.1780497529830072 0.6953172411617885 0.700076649922986 1.0613397251718424 1.0 9.225436038405634 INFS(ph)DLDQR ddPTM_A459_Selumetinib_30min_R1 4 INFSDLDQR 9 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 INFS(1)DLDQR;INFS(1)DLDQR;INFS(1)DLDQR;INFS(1)DLDQR 110.98 0.01054 18695300.0 9151.5 9735.3 9767.5 10849.9 9739.4 9063.1 9904.6 9655.9 4596.45 7203.0 True False 9364.712144280815 8595.486550181819 8441.127149037007 8955.168642847388 8858.472989630734 8971.933442636398 9157.488047760791 9399.794165216459 7799.839938574544 8127.575213161509 1.152214762542699 1.0575708405949404 1.0385787799745911 1.1018253794004518 1.0899281467473392 1.1038880856011724 1.1267183394293883 1.1565311816487116 0.9596761314424699 1.0 12.988609286442442 -8.272326904797797 24.918233247364483 0.9798380437830402 1.1000092043371619 0.6493773795889577 0.036250831702885684 509.6287475265579 1166372.07291375 0.03530427373042533 0.009493856216068927 5.34162130247098e-09 8.272326904797797 0.12017116055412169 INFS(ph)DLDQR ddPTM_A459_Selumetinib_30min_R2 1 INFSDLDQR 9 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 INFS(1)DLDQR 84.169 0.036953 2321000.0 16120.0 14054.0 19902.0 17385.0 20595.0 15384.0 14667.0 16927.0 12964.0 19334.0 True False 15224.114933472836 15131.89660926751 18621.526987659192 15017.133009202224 18007.67197836396 17503.00635795235 15349.044562109133 16976.254767584294 15557.162244424862 18775.77718423522 0.8108380699284992 0.8059265116318468 0.9917846172191721 0.7998141894126821 0.9590906305323975 0.9322120829516697 0.8174918359702688 0.9041572341323977 0.8285762070870326 1.0 14.196585005884788 INGTVTENMS(ph)LTDAK ddPTM_A459_Selumetinib_30min_R1 1 INGTVTENMSLTDAK 15 0 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 INGTVTENMS(0.997)LT(0.003)DAK 200.71 1.8072e-05 4531500.0 1053.9 1333.8 1361.3 1509.8 1348.7 1112.0 1194.7 1380.3 629.72 1015.6 True False 1078.453819467579 1177.638075933203 1176.4429370856499 1246.141772456059 1226.710323132325 1100.8142896152165 1104.582817141512 1343.689960153717 1068.588847070927 1145.9621527817344 0.9410902592635506 1.0276413344669173 1.0265984214486714 1.0874196581720839 1.0704632087146861 0.9606026577257155 0.9638911847657644 1.1725430520475861 0.9324817966082128 1.0 10.162343682251013 -4.760394024182809 5.438883512895212 1.0317432405097247 0.9364493613605286 0.12491770164329496 0.06706385840485589 0.31786840095976526 29.094172670845662 0.01623717059216441 0.11449173690271139 1.7362248818920746e-05 4.760394024182809 -0.09529387914919607 INGTVTENMS(ph)LTDAK ddPTM_A459_Selumetinib_30min_R2 1 INGTVTENMSLTDAK 15 0 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 INGTVT(0.044)ENMS(0.923)LT(0.032)DAK 109.67 0.0036899 2716100.0 13184.0 14520.0 14718.0 14651.0 13100.0 11349.0 14075.0 14148.0 9816.2 11500.0 True False 12451.286059733618 15633.637310841339 13771.059903746775 12655.5085256153 11454.2608845141 12912.221734035431 14729.515389083403 14189.16833767251 11779.714287544224 11167.96511941165 1.114910901547441 1.3998644465380412 1.2330858626886776 1.1331973542447826 1.0256354458526042 1.1561839239264808 1.3189077178868716 1.270524055721623 1.0547771381439273 1.0 13.447078720288232 -8.414141175796894 4.7600261305968115 1.0024619067301388 1.2069626145470684 0.3353175458876304 0.1020530144069105 0.2607528447596159 8.533674119989273 0.1061196336911883 0.027689148844274678 3.853530708560506e-09 8.414141175796894 0.20450070781692964 INHEGEVNR ddPTM_A459_Selumetinib_30min_R1 2 INHEGEVNR 9 0 E9PC52;Q16576;Q16576-2;Q5JP01;Q09028-3;Q09028;Q09028-4;Q09028-2 E9PC52;Q09028-3 RBBP7;RBBP4 Histone-binding protein RBBP7;Histone-binding protein RBBP4 0 ; 148.56 0.0021354 14789100.0 9127.8 10037.5 10661.2 10264.9 10575.599999999999 10057.599999999999 8712.0 9173.900000000001 7984.9 7943.4 False True 9340.45998039299 8862.30483369285 9213.467597779723 8472.327911037351 9619.03884727383 9956.429675570145 8054.84682592856 8930.578370973113 13549.792105978275 8963.012765268235 1.0421116453819375 0.9887640535372626 1.0279431524946616 0.9452544733471437 1.073192585929109 1.110835155133485 0.8986762639835986 0.9963813066940164 1.5117452647712224 1.0 13.129768036021805 -8.177138822816872 24.999996080279963 1.2559046596997405 1.0098041751085962 0.37068554620403005 0.12793706975651084 70.64498004365309 20949.06879157901 0.07903748714110692 0.029873351374317222 6.650605347242914e-09 8.177138822816872 -0.2461004845911443 INHEGEVNR ddPTM_A459_Selumetinib_30min_R2 1 INHEGEVNR 9 0 E9PC52;Q16576;Q16576-2;Q5JP01;Q09028-3;Q09028;Q09028-4;Q09028-2 E9PC52;Q09028-3 RBBP7;RBBP4 Histone-binding protein RBBP7;Histone-binding protein RBBP4 0 172.59 0.00068004 9647100.0 84534.0 78980.0 78570.0 93408.0 100890.0 69895.0 84413.0 95351.0 90881.0 114240.0 False True 79835.93869641394 85037.51203927319 73514.89174054805 80685.6692622123 88215.29623195628 79522.4018063623 88338.37176118627 95628.45562379225 109059.7394273045 110941.59436883373 0.719621339053352 0.7665070303258807 0.6626449904455332 0.7272805995014519 0.7951507884290706 0.7167951953347997 0.7962601607067108 0.8619711675124139 0.9830374265645322 1.0 16.759440838485595 -7.970158167622429 1.314243450162416 1.0081500163118307 0.7301857548018625 0.9030157851143914 0.033534767504502946 0.12588403020190045 0.3909744829054649 0.030320380510496354 0.01047253570212761 1.0711291349500916e-08 7.970158167622429 -0.2779642615099681 INHTVILDDPFDDPPDLLIPDRS(ph)PEPTR ddPTM_A459_Selumetinib_30min_R2 4 INHTVILDDPFDDPPDLLIPDRSPEPTR 28 1 Q8WUA2 Q8WUA2 PPIL4 Peptidyl-prolyl cis-trans isomerase-like 4 1 INHTVILDDPFDDPPDLLIPDRS(0.757)PEPT(0.243)R;INHTVILDDPFDDPPDLLIPDRS(0.752)PEPT(0.248)R;INHTVILDDPFDDPPDLLIPDRS(0.729)PEPT(0.271)R;INHTVILDDPFDDPPDLLIPDRS(0.874)PEPT(0.126)R 109.18 3.176e-10 32241400.0 42593.4 36788.7 47794.7 44337.899999999994 47693.4 31107.0 33246.200000000004 40862.7 32150.2 45191.8 True False 40226.2293428897 39610.2749956852 44719.64103693472 38299.00153285634 41701.72870759426 35391.70688876907 34792.21417609553 40981.603691815835 38581.13835164364 43886.99531160243 0.916586543628223 0.9025515352429107 1.018972493318816 0.872673129270511 0.9502069670413172 0.8064281146951188 0.7927681977102107 0.9337983473428062 0.8791018404817502 1.0 15.421505880153973 -6.722280238352105 24.999459097668037 0.872678288548066 0.9320649778471641 0.11673373608427351 0.06578946578913582 299.2561277948162 191046.27847897832 0.021505248694912736 0.021504891074474206 1.8954824235384704e-07 6.722280238352105 0.05938668929909818 INPPSSGGTSSS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 4 INPPSSGGTSSSPIK 15 0 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6;A0A0A0MT46 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 INPPSSGGT(0.021)S(0.068)S(0.217)S(0.694)PIK;INPPS(0.046)S(0.046)GGT(0.046)S(0.03)S(0.141)S(0.691)PIK;INPPSSGGTSS(0.081)S(0.918)PIK;INPPSSGGT(0.011)S(0.051)S(0.235)S(0.702)PIK 181.69 2.0483e-05 204880000.0 10514.400000000001 11374.3 10719.500000000002 10467.2 10219.2 9031.49 9706.329999999998 9021.5 6263.21 9554.8 True False 10759.365062539058 10042.591668231393 9263.850777998696 8639.300013678674 9294.875164346295 8940.641410536813 8974.173713488888 8782.220514038081 10628.209923240642 10781.251651633425 0.9979699398732567 0.9314866207310799 0.8592555927024638 0.8013262553211776 0.862133216502563 0.8292767574145485 0.8323869995307313 0.8145826475265997 0.9858048273671827 1.0 13.396237057341246 -10.934303852955267 3.558632417935137 1.0010231740274893 0.8727387252899838 0.22321748856723822 0.06649170026453563 25826672.19895194 100447.94707669265 216501.4871346847 0.01668186794962596 1.1633118366514027e-11 10.934303852955267 -0.12828444873750555 INPPSSGGTSSS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 6 INPPSSGGTSSSPIK 15 0 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6;A0A0A0MT46 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 INPPSSGGT(0.001)S(0.111)S(0.371)S(0.516)PIK;INPPSSGGTS(0.013)S(0.295)S(0.691)PIK;INPPSSGGT(0.001)S(0.002)S(0.229)S(0.768)PIK;INPPSSGGT(0.002)S(0.008)S(0.068)S(0.922)PIK;INPPSSGGTSS(0.029)S(0.971)PIK;INPPS(0.002)S(0.002)GGT(0.008)S(0.018)S(0.065)S(0.905)PIK 221.34 1.7505e-09 287759100.0 205887.0 183227.0 197572.0 216291.0 204385.0 156298.0 174660.0 182194.0 146135.0 199208.0 True False 194444.62477096307 197279.92173233637 184860.43262012908 186831.79267721408 178708.32907491698 177826.63076802102 182782.03608222405 182724.15437615977 175366.08335305622 193456.3474354575 1.0051085288676573 1.0197645326584828 0.955566643693631 0.9657568498213606 0.9237656527891345 0.9192080442196346 0.9448231526401857 0.9445239548788738 0.9064891675966502 1.0 17.561648539808402 -5.440008857409486 1.6422587716093668 0.9377759663538316 1.0167829044693608 0.5214046531199901 0.025462835054853833 0.3016015797817905 1.500341948504627 0.007248309913333496 0.02484246030026006 3.630706498908168e-06 5.440008857409486 0.07900693811552917 INPYMS(ph)SPCHIEMILTEK ddPTM_A459_Selumetinib_30min_R1 2 INPYMSSPCHIEMILTEK 18 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 INPY(0.033)MS(0.615)S(0.352)PCHIEMILTEK;INPYMS(0.608)S(0.392)PCHIEMILTEK 124.08 0.00057794 235650000.0 10179.5 10526.8 12433.0 12641.5 12392.2 9559.7 11577.5 10061.1 4816.7 8222.5 True False 10416.662544141027 9294.317362223444 10744.666889580456 10433.899335344586 11271.327698020605 9463.53809751312 10704.199853901271 9794.246944941364 8173.588102151006 9277.93796893246 1.1227346614109333 1.0017654131064286 1.1580878127833356 1.1245924870680217 1.2148526683152108 1.0200044588789179 1.1537261716714107 1.0556491084266553 0.8809703330115579 1.0 13.179588485213634 -8.064903373003323 4.998105040396336 0.9438266273152206 1.11159895994336 0.5236167567201563 0.06526069132695943 0.1686210897787049 8.190457258965427 0.04443369444384124 0.01642687789603888 8.611853376173361e-09 8.064903373003323 0.1677723326281394 INS(ph)VEQNDMLR ddPTM_A459_Selumetinib_30min_R2 1 INSVEQNDMLR 11 0 A0A087WXD1;Q96T83 A0A087WXD1 SLC9A7 Sodium/hydrogen exchanger;Sodium/hydrogen exchanger 7 1 INS(1)VEQNDMLR 69.672 0.045277 4512500.0 13566.0 13139.0 12861.0 11478.0 9998.5 12976.0 12539.0 13070.0 8483.8 15563.0 True False 12812.056029000785 14146.719051456223 12033.537261998037 9914.676599345592 8742.399042275896 14763.32621559995 13122.088345557133 13108.031536145028 10180.797057177688 15113.655752469882 0.8477138978706084 0.9360223153914538 0.7962029477898827 0.6560078356770387 0.5784437058417986 0.9768203310563904 0.8682272879883951 0.8672972145738403 0.6736157832306017 1.0 13.883565047202612 -9.830956511004295 17.343245193818255 0.9999999995364335 0.8023551646069236 0.19635682671174104 0.12127843288038895 0.0 0.0 0.12524160467230963 0.030375550869751942 1.4758543136671223e-10 9.830956511004295 -0.1976448349295099 INSS(ph)GESGDESDEFLQSR ddPTM_A459_Selumetinib_30min_R2 1 INSSGESGDESDEFLQSR 18 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 INS(0.019)S(0.666)GES(0.312)GDES(0.003)DEFLQSR 241.13 4.2145000000000005e-25 5556500.0 9771.5 10285.0 11745.0 9829.4 10855.0 6881.7 7280.6 7103.0 5595.8 8971.2 True False 9228.439148413761 11073.826428512613 10989.33948698911 8490.618763339227 9491.297855068738 7829.591709147203 7619.162326235208 7123.668554035049 6715.116359715569 8712.178146023121 1.0592573973738473 1.271074379208777 1.2613768110338117 0.9745690022666685 1.0894288082712433 0.8986950884057857 0.8745416127324203 0.8176679166376798 0.770773536441153 1.0 13.088817739148086 -6.466126063209502 1.063425230540997 0.8445920887182367 1.19518821322115 0.6566171197638343 0.09552100559303656 0.2873701615407997 0.6913806931288549 0.04513035132191282 0.05527296678140175 3.418801901134084e-07 6.466126063209502 0.35059612450291333 INSS(ph)PNVNTTASGVEDLNIIQVTIPDDDNER ddPTM_A459_Selumetinib_30min_R1 2 INSSPNVNTTASGVEDLNIIQVTIPDDDNER 31 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 INS(0.258)S(0.69)PNVNT(0.025)T(0.025)AS(0.001)GVEDLNIIQVTIPDDDNER;INS(0.24)S(0.76)PNVNTTASGVEDLNIIQVTIPDDDNER 216.27 1.1878e-56 13134000.0 890.02 1138.72 1059.53 993.1800000000001 872.01 823.69 1198.04 902.52 603.33 926.77 True False 910.7557343225501 1005.3981330234345 915.6516455816923 819.7397572975942 793.1368494658698 815.4044264506821 1107.6708782524618 878.5822378018778 1023.806944520266 1045.7299570042605 0.8709282240815058 0.9614318938549241 0.8756100362705413 0.7838923919191639 0.7584528339782833 0.7797466458612315 1.059232233745742 0.8401616802857818 0.9790356847509675 1.0 10.03029463147725 -8.340963740501284 4.753148207579478 0.9979128568330518 0.8668703875365732 0.24989639566133504 0.08553491637815436 0.34665064591923933 13.504026822846344 0.08697965107494537 0.022996633941822397 4.560749923279556e-09 8.340963740501284 -0.13104246929647856 INSSGESGDES(ph)DEFLQSR ddPTM_A459_Selumetinib_30min_R1 2 INSSGESGDESDEFLQSR 18 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 INSSGESGDES(1)DEFLQSR;INSSGES(0.005)GDES(0.995)DEFLQSR 269.34 6.0662e-54 13502700.0 1823.57 2843.3999999999996 2449.8999999999996 2465.9 2069.3599999999997 2058.3199999999997 2284.7 1586.1799999999998 1115.49 1803.29 True False 1866.0556329504648 2510.4934061392023 2117.217036337422 2035.2768556758485 1882.1867533751808 2037.6151696050288 2112.363239577476 1544.1093537612273 1892.905057833876 2034.759837032073 0.9170888863583614 1.233803302212334 1.0405242907809809 1.0002540932027288 0.9250166624679219 1.0014032774389339 1.0381388511474634 0.758865653655463 0.9302842642082477 1.0 10.990642807718876 -5.884370512956388 2.3424966368201234 0.938215816511443 1.084796620031743 0.22253147271956486 0.10087174333879319 0.3971766143090794 4.4300209783522115 0.030827355983028045 0.05185805251495932 1.305057019830936e-06 5.884370512956388 0.1465808035202999 INSSGESGDES(ph)DEFLQSR ddPTM_A459_Selumetinib_30min_R2 1 INSSGESGDESDEFLQSR 18 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 INSSGES(0.43)GDES(0.57)DEFLQSR 271.58 4.2173e-54 6108100.0 9853.5 8800.5 9989.4 10351.0 9394.2 8278.0 6298.6 7483.2 6980.0 6120.3 True False 9305.88191668577 9475.470051932454 9346.692879636365 8941.175943529039 8214.016610786433 9418.219359797811 6591.497380439124 7504.974873089546 8376.195037495023 5943.591036550882 1.56570024072283 1.5942331822061488 1.5725666221241785 1.5043390247653516 1.381995591599973 1.5846008417940018 1.1090092403571945 1.262700415781761 1.4092818610810416 1.0 12.537119135761003 -7.479291032112739 0.16536920539973626 0.8310603101076146 1.8679641233875046 0.6865561986878173 0.11250818852019362 2.757627042079798 0.37050155276215735 0.8228633023439041 1.1311126290752171 3.316721208846515e-08 7.479291032112739 1.03690381327989 INVYYNEATGGK ddPTM_A459_Selumetinib_30min_R2 1 INVYYNEATGGK 12 0 P68371 P68371 TUBB4B Tubulin beta-4B chain 0 173.04 0.0027743000000000004 9758400.0 55290.0 44096.0 59264.0 60347.0 60022.0 35973.0 47417.0 47356.0 33420.0 53632.0 False True 52217.203143406536 47478.0214090124 55451.01876176437 52127.63449561848 52481.49975651186 40927.95421961907 49621.984455003025 47493.79811979218 40104.93383281999 52083.50480732922 1.0025669996013498 0.9115750098739758 1.0646560550579782 1.0008472872256293 1.0076414778662637 0.7858141338802466 0.9527389648328772 0.9118779217236708 0.7700121944784407 1.0 15.668538913268485 -6.727124541148154 24.99818039667625 0.8828715939909297 0.9966077918080454 0.37455346352991625 0.07323637451372973 196.33978112595187 143032.03563987484 0.023342459027096606 0.02334138235946118 1.8744568993716062e-07 6.727124541148154 0.11373619781711564 INYTEGR ddPTM_A459_Selumetinib_30min_R2 2 INYTEGR 7 0 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41;A0A2R8YF08;K7ELR7;K7ERK8 P06744-2 GPI Glucose-6-phosphate isomerase 0 ; 161.9 0.0077333 33595000.0 123710.0 128539.0 146711.0 152008.0 167690.0 100453.0 96825.0 121696.0 96773.0 121480.0 False True 116834.69345036751 138397.52798197232 137271.7739868594 131304.24817157365 146623.28303237946 114289.48892845714 101327.55435509772 122050.11521214271 116130.30406353925 117972.55675705466 0.9903548474495608 1.1731332420554348 1.163590734661692 1.1130067176722587 1.2428592467850497 0.9687803000134837 0.8589078438281658 1.0345636185836433 0.9843840572404544 1.0 16.848091767623956 -6.788443123468673 23.387973277346198 0.964585921489681 1.1388091101775633 0.5681800352241184 0.0728365247764124 76.99204736966944 66681.9519781639 0.025474391467514512 0.02247480960140205 1.627634461663356e-07 6.788443123468673 0.17422318868788222 IPAVTLAVTSVAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 IPAVTLAVTSVAGSPAR 17 0 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 IPAVT(0.001)LAVT(0.016)S(0.103)VAGS(0.88)PAR;IPAVTLAVT(0.018)S(0.124)VAGS(0.858)PAR 124.45 0.0013104000000000002 46218000.0 1225.81 1330.33 2203.56 1841.4899999999998 1551.27 1111.28 979.87 1102.24 843.54 1056.51 True False 1254.3689879889498 1174.5743451463625 1904.3286552886611 1519.9083405484876 1410.9579023989634 1100.101532161509 905.9576170021367 1073.0050146198898 1431.4257702760106 1192.1233497788783 1.0522140919575287 0.9852792040053817 1.5974258499692056 1.274958955237651 1.1835670383108223 0.9228084764597239 0.7599529169277481 0.90007885074889 1.2007362917113564 1.0 10.219317804780406 -6.703419820182957 4.712572878034376 0.9375867021993911 1.2347906610027435 0.33662627129889733 0.18323096870778788 0.24128104989894703 10.852714184349976 0.06649252540703732 0.06505080134184238 1.9796124652411858e-07 6.703419820182957 0.2972039588033524 IPAVTLAVTSVAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 IPAVTLAVTSVAGSPAR 17 0 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 IPAVTLAVT(0.017)S(0.024)VAGS(0.959)PAR;IPAVTLAVTSVAGS(0.999)PAR 176.68 9.2631e-08 15272400.0 3151.5 2402.5 6519.1 8948.0 8027.5 6261.200000000001 5455.7 3653.0 3126.34 6568.400000000001 True False 2976.352246454073 2586.7640247449276 6099.6682034594105 7729.266963839027 7019.013683239459 7123.623466485387 5709.400860264459 3663.629625213293 3751.695357238134 6378.753225247263 0.46660407470751447 0.40552815470372044 0.9562477161393818 1.211720643659077 1.1003739187554755 1.116773641326946 0.895065329956097 0.5743488571892946 0.5881549614411843 1.0 12.639058750732543 -5.26220141297138 24.922774855153868 0.9366549245114363 0.4360660748957592 0.49678652218604435 0.19890124217185576 57.007203797541 1864536.0371840436 0.05971467271832264 0.13735153041826756 5.467623318422258e-06 5.26220141297138 -0.5005888496156771 IPCDS(ph)PQSDPVDT(ph)PTSTK ddPTM_A459_Selumetinib_30min_R2 1 IPCDSPQSDPVDTPTSTK 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 2 IPCDS(1)PQSDPVDT(0.99)PT(0.008)S(0.002)TK 125.79 0.008996299999999999 0.0 8798.6 10554.0 10110.0 8473.1 10125.0 7046.6 8201.8 8265.0 8889.2 12038.0 True False 8309.609035586489 11363.457863541289 9459.533606935709 7319.049163087224 8853.00698135154 8017.205187334044 8583.199951558376 8289.04978165559 10667.288385000107 11690.431661519782 0.7108042950149046 0.9720306480166374 0.8091688896375575 0.6260717632162892 0.7572865774060417 0.6857920579377297 0.7342072730993187 0.7090456555971173 0.9124802824956881 1.0 13.513040580970461 -8.441996026872982 3.827005942795839 0.998084487813309 0.753715176798528 0.4816168442859332 0.08738766722431963 0.19199700843016212 5.159929512681302 0.08948343684961788 0.023560250405729777 3.614131689995098e-09 8.441996026872982 -0.2443693110147811 IPCDSPQSDPVDT(ph)PTSTK ddPTM_A459_Selumetinib_30min_R2 1 IPCDSPQSDPVDTPTSTK 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCDS(0.002)PQS(0.012)DPVDT(0.753)PT(0.166)S(0.061)T(0.006)K 80.541 0.026141 2225500.0 9538.4 10995.0 9730.8 4670.7 6903.7 5658.5 4858.3 4258.9 2959.8 10041.0 True False 9008.29391324053 11838.281145502799 9104.730922093966 4034.5426025930883 6036.395486138928 6437.907012251256 5084.220576538821 4271.292693901148 3551.842703721743 9751.090240348913 0.9238242792549725 1.2140469274417465 0.9337141486415145 0.4137529756312382 0.6190482640762572 0.6602243291331591 0.5214002179470034 0.43803232137335985 0.36425082900213746 1.0 13.25134781597682 -5.624680865528634 5.004665872553664 0.555104902442823 1.0701342641204679 0.5683473834928603 0.1813029261150715 0.1301881438362253 5.244208522929026 0.04751314893027317 0.0843067771391723 2.3731169127485117e-06 5.624680865528634 0.5150293616776449 IPCES(ph)PPLEVVDTTASTK ddPTM_A459_Selumetinib_30min_R1 3 IPCESPPLEVVDTTASTK 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCES(1)PPLEVVDTTASTK;IPCES(1)PPLEVVDTTASTK;IPCES(1)PPLEVVDTTASTK 166.9 1.3875e-07 29140300.0 2962.3599999999997 10956.0 3501.38 5435.1 4171.34 4311.95 4674.6 3157.66 1575.3899999999999 3527.2200000000003 True False 3031.3772242508576 9673.26642669378 3025.91182770363 4485.961814462792 3794.0430335098913 4268.575697937351 4321.991158457951 3073.908599274784 2673.3217680668663 3979.9730450322845 0.7616577273141476 2.43048541214814 0.7602845028009693 1.127133717667277 0.9532836003111963 1.072513720479915 1.0859347813555085 0.7723440748201975 0.6716934355632505 1.0 11.958542944594344 -5.352945403696148 24.99894042860169 0.9407407284454077 1.5967362763741741 0.30644128619496847 0.4003338945441524 59.11254444502894 16146.002912766102 0.0962179849928681 0.20029373291257718 4.436644146486082e-06 5.352945403696148 0.6559955479287665 IPCES(ph)PPLEVVDTTASTK ddPTM_A459_Selumetinib_30min_R2 2 IPCESPPLEVVDTTASTK 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCES(1)PPLEVVDTTASTK;IPCES(1)PPLEVVDTTASTK 161.48 1.0195e-05 10553500.0 56216.0 70041.0 68877.0 31601.0 35533.0 34252.0 37654.0 36003.0 29181.0 64915.0 True False 53091.73977047822 75412.9194826887 64445.528807607356 27296.889285234385 31069.026870949565 38969.90209130158 39404.985609985524 36107.7627693825 35018.01538526393 63040.73528057459 0.8421814805011949 1.1962569780801158 1.0222839013660052 0.4330039801049983 0.49284049008424546 0.6181701707294297 0.6250717957937239 0.5727687440300012 0.5554823437482082 1.0 15.94399674142896 -5.746866051014792 24.585377496896427 0.5917026794123965 1.0378427162644426 0.5601985858603904 0.1639422642217663 123.25406497065057 207928.85436115396 0.041897316815281735 0.07214070106613499 1.7911582138721543e-06 5.746866051014792 0.44614003685204606 IPCES(ph)PPLEVVDTTASTKR ddPTM_A459_Selumetinib_30min_R2 4 IPCESPPLEVVDTTASTKR 19 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCES(1)PPLEVVDTTASTKR;IPCES(1)PPLEVVDTTASTKR;IPCES(1)PPLEVVDTTASTKR;IPCES(1)PPLEVVDTTASTKR 130.17 0.0001504 15368500.0 49752.9 85242.0 65320.0 42311.0 41408.1 32620.300000000003 28505.4 26199.9 26732.9 67742.0 True False 46987.83299463903 91779.7873037699 61117.38231503863 36548.16880945389 36206.04428488916 37113.450227399415 29830.957582378545 26276.137371373068 32080.22697963478 65786.11244514641 0.7142515532258923 1.395124045067984 0.9290316761915267 0.5555605499554086 0.5503599914811562 0.5641532665172341 0.4534537225809187 0.3994176946279135 0.4876443642476035 1.0 16.00549544039245 -5.68537232435931 3.8965836932495788 0.5396517900421368 1.0764442931392064 0.4587622506639526 0.21868087972934974 0.16152080984832665 4.7464067801631336 0.05720284065498562 0.10192246728720718 2.0636102465944627e-06 5.68537232435931 0.5367925030970696 IPCESPPLEVVDT(ph)TAST(ph)K ddPTM_A459_Selumetinib_30min_R1 1 IPCESPPLEVVDTTASTK 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 2 IPCESPPLEVVDT(0.646)T(0.354)AS(0.233)T(0.767)K 106.31 0.013704 4701500.0 533.23 676.24 838.7 745.01 835.13 647.26 777.87 786.56 405.33 548.32 True False 545.6532215150369 597.0655064245532 724.8091466493314 614.9079890697367 759.5926389541772 640.7491520650588 719.1946396332704 765.6978736930431 687.8154058680981 618.7022130890908 0.881931905157845 0.965028884321411 1.1714991983469139 0.9938674471513361 1.227719285440472 1.0356341686025183 1.1624245467661016 1.2375870935874371 1.1117067166027015 1.0 9.27310138423532 -5.0905062185838155 3.5375551560492906 1.1241448398685314 0.8925430672772623 0.47738743385647775 0.08275659881150568 0.18539715939635598 4.2229969893869805 0.020676902075793008 0.07246889324735796 8.118836236382816e-06 5.0905062185838155 -0.23160177259126913 IPCKS(ph)PPPELTDTATSTK ddPTM_A459_Selumetinib_30min_R2 1 IPCKSPPPELTDTATSTK 18 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCKS(1)PPPELTDTATSTK 98.572 0.0017815 32986000.0 62158.0 78345.0 68754.0 43977.0 45117.0 45552.0 42448.0 56019.0 36219.0 64966.0 True False 58703.5071981889 84353.80958112012 64330.44249369509 37987.25673544357 39448.99910890246 51826.37452011476 44421.91610911631 56182.00601555534 43463.812043414364 63090.26277806065 0.9304685796712638 1.337033733364854 1.019657228564686 0.6021096610276516 0.6252787256200916 0.8214639191221937 0.7041009840993059 0.890502013174248 0.6889147410324102 1.0 15.945129739340384 -5.58675230270348 5.847513705459495 0.7531555696980274 1.1448447820905587 0.5306316890608356 0.14616524269246983 0.1286962140591104 8.370413472832405 0.038022705732587904 0.06717590637773464 2.589689508168405e-06 5.58675230270348 0.3916892123925313 IPCKS(ph)PPPELTDTATSTKR ddPTM_A459_Selumetinib_30min_R1 1 IPCKSPPPELTDTATSTKR 19 2 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCKS(1)PPPELTDTATSTKR 70.235 0.0063797 12748000.0 1741.6 2799.8 3007.6 4156.0 2574.4 2132.1 2237.0 2312.0 1203.6 1782.7 True False 1782.175891436318 2471.998114408293 2599.1844395642393 3430.232617782077 2341.5459745472363 2110.65300979191 2068.2612889809666 2250.678249565596 2042.4212925340896 2011.5269099684879 0.8859816304740546 1.2289162536965608 1.2921450002401198 1.70528795850701 1.1640639570583315 1.049279032426653 1.0282046333714558 1.1188904500416823 1.0153586722665746 1.0 10.97407532295792 -6.519497325432339 24.261530377606153 1.0553130477179857 1.2954628120884908 0.2582575779726608 0.18695993908719355 139.4423839848162 1000506.3976059388 0.06429414779101869 0.06563075253082122 3.023449190122833e-07 6.519497325432339 0.24014976437050506 IPCKS(ph)PPPELTDTATSTKR ddPTM_A459_Selumetinib_30min_R2 1 IPCKSPPPELTDTATSTKR 19 2 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCKS(1)PPPELTDTATSTKR 57.788 0.019097 9667300.0 55784.0 68976.0 59363.0 45045.0 46355.0 24764.0 30103.0 31109.0 25294.0 60747.0 True False 52683.74860104523 74266.23740720324 55543.64920954747 38909.79329304081 40531.47048104204 28175.016214790154 31502.849147962857 31199.5220396278 30353.506773409616 58993.0762703391 0.893049692130293 1.2588975198864696 0.9415282728267222 0.6595654228088478 0.6870547027468832 0.4775986945599608 0.5340092624361421 0.5288675216165067 0.514526596889319 1.0 15.848258021878276 -5.7158369873337955 2.726032295523412 0.5933246678365485 1.083814525097087 0.5605477886684223 0.16452545196731674 0.16704264691013498 2.5204919241532884 0.04511578342554591 0.08376162547181507 1.9238136979070373e-06 5.7158369873337955 0.4904898572605385 IPCKS(ph)SPELEDTATSSK ddPTM_A459_Selumetinib_30min_R1 2 IPCKSSPELEDTATSSK 17 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCKS(0.499)S(0.499)PELEDT(0.001)ATSSK;IPCKS(0.956)S(0.044)PELEDTATSSK 111.78 0.0010952 67911000.0 2808.2 9851.9 4347.299999999999 6937.9 3928.9 4259.9 4861.1 3139.7 1611.92 3531.0 True False 2873.6255961940005 8698.434967975947 3756.96053800958 5726.326005512574 3573.5316887036347 4217.049273679734 4494.423313305938 3056.424956817088 2735.3105100212288 3984.2382448526023 0.7212484343541837 2.183211553479214 0.9429557940877026 1.4372448768370327 0.8969171693787198 1.0584330089014906 1.1280508436242396 0.7671290643238532 0.6865328682477978 1.0 11.96008820325047 -6.40753709986457 0.8525487151700616 0.858642931571923 1.4124436597624483 0.18748435486134074 0.38110359427600693 0.9130304342843802 1.4529249953316703 0.20003540938986386 0.27919991923821474 3.912577022771453e-07 6.40753709986457 0.5538007281905254 IPCKSS(ph)PELEDTATSSK ddPTM_A459_Selumetinib_30min_R2 4 IPCKSSPELEDTATSSK 17 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 IPCKS(0.258)S(0.742)PELEDTATSSK;IPCKS(0.212)S(0.787)PELEDTATSSK;IPCKS(0.417)S(0.583)PELEDTATSSK;IPCKS(0.427)S(0.572)PELEDT(0.001)ATSSK 74.703 0.012598 60164600.0 176088.0 295512.0 244527.0 119023.0 102342.0 93353.0 101520.0 88366.0 74092.0 213727.0 True False 166301.73389611457 318176.8201791556 228794.39904086746 102811.86207387254 89484.88301091158 106211.52837584003 106240.88115806362 88623.13043022114 88912.47030345001 207556.14618056527 0.8012373372525377 1.532967469449712 1.1023253382331824 0.49534482098367 0.43113578979763595 0.5117243229378541 0.5118657438630531 0.42698388875038507 0.428377920575283 1.0 17.663142128290808 -5.725519655713422 5.144742107906867 0.510925896813175 1.1977646176621484 0.5852690916333649 0.23071109398046083 0.109646452480755 6.996370229379512 0.059223138405291816 0.10131364682990275 1.8813965542537388e-06 5.725519655713422 0.6868387208489733 IPDWFLNR ddPTM_A459_Selumetinib_30min_R1 1 IPDWFLNR 8 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 149.4 0.019822 3883900.0 1685.2 1741.0 1902.8 2119.5 1737.7 1690.8 1629.3 1676.9 952.07 1760.1 False True 1724.4618811716146 1537.162910631058 1644.4102113322365 1749.3691129425204 1580.525341815853 1673.7920871235688 1506.4005892430437 1632.4231646611368 1615.5932535584348 1986.0259798258467 0.8682977456935541 0.7739893265474054 0.8279902821192872 0.8808389873610422 0.795823094899518 0.842784587979228 0.7584999413628712 0.8219545873233153 0.8134804226982494 1.0 10.955668779996028 -10.792064381196317 6.349996553266613 1.0000041354774225 0.8192016981042972 0.6879906525769864 0.03627492455136485 2.0623688064149713e-06 2.3740160685692838e-07 0.034107976210948354 0.008272210143421997 1.6141192569133948e-11 10.792064381196317 -0.1808024373731253 IPEINSSDMSAHVT(ph)SPSGR ddPTM_A459_Selumetinib_30min_R2 1 IPEINSSDMSAHVTSPSGR 19 0 O75369-8;O75369-2;O75369-9;O75369;E7EN95;O75369-7 O75369-8 FLNB Filamin-B 1 IPEINSSDMSAHVT(0.772)S(0.182)PS(0.045)GR 82.21600000000002 0.0071405 3777000.0 18743.0 16051.0 23320.0 24636.0 23741.0 16700.0 20805.0 17212.0 11755.0 24913.0 True False 17701.33909417378 17282.060087900434 21819.61658889622 21280.53430052955 20758.443332767103 19000.27341249377 21772.473724325395 17262.08407040001 14106.328462142408 24193.69695825239 0.7316508562010369 0.7143207636981491 0.9018719473318699 0.8795900162447406 0.8580103887631141 0.78533981165755 0.8999233875622666 0.7134950933785245 0.5830579959104095 1.0 14.562343619136522 -9.761986185346773 10.15399233406238 1.0000036532846899 0.7927744762023262 0.30059138455602497 0.09766697933177944 0.0 0.0 0.10009417108385253 0.024276402346315822 1.7298713845359858e-10 9.761986185346773 -0.20722917708236366 IPEISIQDMTAQVTS(ph)PSGK ddPTM_A459_Selumetinib_30min_R1 2 IPEISIQDMTAQVTSPSGK 19 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 IPEISIQDMTAQVT(0.091)S(0.894)PS(0.015)GK;IPEISIQDMTAQVT(0.106)S(0.893)PS(0.002)GK 178.52 6.661600000000002e-13 43763000.0 4418.9 4461.1 3249.7 3917.3999999999996 3387.2 3801.6 3397.8 3573.6 2094.8900000000003 3323.6 True False 4521.851772317377 3938.7923380908787 2808.4085893243487 3233.299628705366 3080.8283580587304 3763.359355576625 3141.5012104155257 3478.816519311252 3554.8753252880856 3750.216434605523 1.2057575479088372 1.0502840054097282 0.7488657356971342 0.8621634737850723 0.8215068148147551 1.0035045766558497 0.8376853083536693 0.9276308661041802 0.9479120438183497 1.0 11.872758144303017 -5.002268497889114 4.5404508767671805 0.8890109066816243 1.1826092927787986 0.625390251865166 0.07686941580510587 0.1092830326876498 5.956442958121022 0.0193770661260457 0.07281401629723136 9.94790208858434e-06 5.002268497889114 0.29359838609717426 IPEISIQDMTAQVTS(ph)PSGK ddPTM_A459_Selumetinib_30min_R2 2 IPEISIQDMTAQVTSPSGK 19 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 IPEISIQDMTAQVT(0.032)S(0.967)PS(0.001)GK;IPEISIQDMTAQVT(0.056)S(0.909)PS(0.035)GK 226.08 1.9935e-23 16179200.0 35523.0 27147.7 32938.0 34461.0 34699.0 28023.3 29571.8 27504.8 22494.2 28399.6 True False 33548.77386983597 29229.841296386196 30818.804940182836 29767.352351459198 30339.801407004175 31883.255204810554 30946.947295410027 27584.834414335237 26993.668540461393 27579.629756977658 1.2164330763486089 1.0598344341076962 1.1174481025215963 1.0793238565477132 1.1000800835380393 1.1560436266097471 1.1220943706679178 1.0001887138226089 0.9787538403640819 1.0 14.751315469056978 -7.778325331776795 6.4815957289634 0.9908112428542373 1.1181037612010758 0.6758598055858069 0.04078215884687153 0.09305240196225271 14.92141588436583 0.021163053616722275 0.010594108086324605 1.6659987385061132e-08 7.778325331776795 0.12729251834683852 IPEPES(ph)PAKPNVPTASTAPPADSR ddPTM_A459_Selumetinib_30min_R1 2 IPEPESPAKPNVPTASTAPPADSR 24 1 Q9BZL4-3;K7EL81;K7ER83;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 IPEPES(0.961)PAKPNVPT(0.006)AS(0.016)T(0.016)APPADS(0.001)R;IPEPES(0.991)PAKPNVPT(0.001)AS(0.004)T(0.005)APPADSR 66.041 0.0014661 36821000.0 2973.29 3594.1000000000004 2906.3 3025.7 2905.4 2779.27 2984.79 2997.6 2007.49 2878.4700000000003 True False 3042.5618719847794 3173.3011011482413 2511.6404231631714 2497.3182944232985 2642.6070829900323 2751.313067175255 2759.644887231785 2918.0939104229396 3406.5639087315244 3247.9496631721527 0.9367638625942316 0.9770167121521813 0.7733002920710738 0.7688907013368735 0.8136231644701954 0.8470922743575248 0.8496575296479632 0.8984418519506687 1.0488351920468062 1.0 11.66531355842451 -8.11488899417527 3.455419237346116 1.0238935219943774 0.8499463685086062 0.5394450053320899 0.062467657519439876 0.21220405891013241 4.455607902559613 0.05470955261543758 0.01834596567759093 7.675576523012361e-09 8.11488899417527 -0.17394715348577128 IPEPES(ph)PAKPNVPTASTAPPADSR ddPTM_A459_Selumetinib_30min_R2 4 IPEPESPAKPNVPTASTAPPADSR 24 1 Q9BZL4-3;K7EL81;K7ER83;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 IPEPES(0.982)PAKPNVPT(0.005)AS(0.006)T(0.006)APPADS(0.001)R;IPEPES(1)PAKPNVPTASTAPPADSR;IPEPES(1)PAKPNVPTASTAPPADSR;IPEPES(0.999)PAKPNVPTASTAPPADSR 86.439 5.2814e-05 85985000.0 83323.0 70563.0 81071.0 79269.0 81527.0 65580.0 80398.0 83716.0 56016.1 73565.0 True False 78692.24122839679 75974.9552041942 75854.9801234307 68472.42545334781 71284.84939937257 74613.04972403233 84136.6663056148 83959.59970007007 67220.8852206052 71440.98730517556 1.1014999119797426 1.063464519039341 1.061785159818688 0.9584473568492706 0.997814449216162 1.044401155954167 1.1777086162906303 1.175230114631795 0.9409288386995089 1.0 16.12446439800464 -7.026181642367673 24.60245991405439 1.0913530452296176 1.0337473276477873 0.029211890476410374 0.07660702953590173 1459.55895081661 1371520.1607766866 0.02970473537412998 0.02309942842987517 9.414957363883257e-08 7.026181642367673 -0.05760571758183031 IPEPS(ph)PVTR ddPTM_A459_Selumetinib_30min_R1 1 IPEPSPVTR 9 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 IPEPS(1)PVTR 99.343 0.018892 2566600.0 913.86 906.05 938.42 838.21 1029.8 644.45 871.6 1126.3 509.05 653.03 True False 935.1511599379853 799.9692447887826 810.987718372082 691.8323586504127 936.6547718259566 637.9674181137829 805.8545102708139 1096.4268652619949 863.8206704590217 736.852761550862 1.269115362979386 1.0856568456160476 1.1006102720782198 0.9389017653870302 1.2711559496018838 0.8658004032868736 1.093643876118104 1.4879863691551258 1.1723110986799166 1.0 9.525232557532027 -7.567554702511744 24.999924295203876 1.2562525582718402 1.0812282536057318 0.10697198993947366 0.16274134693014228 212.40899742061328 118858.22561276652 0.07266632816664553 0.04195394097460763 2.7067322500658782e-08 7.567554702511744 -0.1750243046661084 IPEPS(ph)PVTR ddPTM_A459_Selumetinib_30min_R2 1 IPEPSPVTR 9 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 IPEPS(0.994)PVT(0.006)R 87.667 0.032216 5735400.0 29758.0 23725.0 31837.0 29827.0 32584.0 28787.0 24483.0 32501.0 27565.0 23730.0 True False 28104.169490712466 25544.631212101296 29788.642081504662 25764.51114555508 28490.506615344068 32752.147947632217 25621.508012144135 32595.57252916982 33078.77023045132 23044.853242055542 1.2195421335738412 1.1084744582136805 1.2926375259852856 1.1180158482648228 1.23630670658169 1.4212348242626869 1.1118104221807907 1.4144404473656949 1.4354081530918346 1.0 14.492156959650444 -6.525828093913749 24.969978431422312 1.2962485533477002 1.1857152678038902 0.07989691863563797 0.1392346565096084 191.88312858990986 1624506.19061504 0.04367366366736073 0.043902156384402036 2.979695644164731e-07 6.525828093913749 -0.11053328554380992 IPESETESTASAPNS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 IPESETESTASAPNSPR 17 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 IPES(0.001)ET(0.008)ES(0.014)T(0.053)AS(0.156)APNS(0.768)PR 100.27 0.004455399999999999 9797400.0 716.75 764.19 641.82 726.6 920.11 850.78 753.72 695.24 180.44 523.18 True False 733.4488804472795 674.7182795377073 554.6643692649028 599.7129499712357 836.8862129586149 842.2219256464339 696.8662935765464 676.7999767422086 306.1935011838245 590.335249204753 1.242427724645134 1.142940863596791 0.9395752159677017 1.0158853817032194 1.4176456752091178 1.4266841202198244 1.180458552179126 1.1464671602346856 0.5186773136049406 1.0 9.205390678154492 -8.14596793094461 6.870663611118874 0.7631315981474466 1.1913871152942945 0.4793835338108948 0.1795217457103788 0.21307061386072346 11.07894098445854 0.13031534177349322 0.048501672118884606 7.145490876674955e-09 8.14596793094461 0.42825551714684795 IPESETESTASAPNS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IPESETESTASAPNSPR 17 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 IPESETESTASAPNS(1)PR 177.07 3.4542e-09 0.0 3365.0 3947.0 4245.5 4686.2 4686.6 2635.5 4298.5 3843.2 3694.0 4602.1 True False 3177.986771162291 4249.7222083946845 3972.349152150898 4047.9314758540963 4097.827409264411 2998.5162023130124 4498.38876731616 3854.3830757239884 4432.903218983758 4469.225415308207 0.7110822292106586 0.9508856263634254 0.888822733922665 0.905734461723261 0.9168987975474081 0.6709252552002299 1.0065253705727308 0.8624275389023274 0.9918728206905751 1.0 12.12580909675816 -8.12681335935214 1.2915184895817782 1.0022305525802335 0.8606263347162713 0.22934161061731606 0.09676464825483765 0.6981117082989999 2.1535097376863592 0.0867511928235929 0.02842277701255446 7.467696181636723e-09 8.12681335935214 -0.14160421786396227 IPEVPLHDT(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 IPEVPLHDTPER 12 0 Q96AY2;Q96AY2-2 Q96AY2 EME1 Crossover junction endonuclease EME1 1 IPEVPLHDT(1)PER 96.096 0.023635 2213400.0 12531.0 11105.0 12562.0 12080.0 10894.0 9431.3 10271.0 10588.0 7894.5 10048.0 True False 11834.577185567507 11956.717791797048 11753.774596471454 10434.68316083768 9525.398326404322 10730.375966182779 10748.621851600396 10618.809327062247 9473.620590759952 9757.88813216073 1.2128215680770391 1.225338682905091 1.2045408224892988 1.0693587607800423 0.9761741677494589 1.0996617117198604 1.1015315717931153 1.088228229637521 0.9708679237196962 1.0 13.25235322846076 -5.772571312778804 4.337930464997873 1.0477929337557503 1.2181547828070975 0.7484991863982046 0.04546524764738278 0.10278845477440822 4.540662617293308 0.013267129781990558 0.021779937695563925 1.688218624911364e-06 5.772571312778804 0.17036184905134721 IPGGNIYIS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 2 IPGGNIYISPLK 12 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 IPGGNIYIS(1)PLK;IPGGNIY(0.001)IS(0.999)PLK 104.9 0.0095466 34412000.0 3655.8 5617.0 2838.7 2876.4 2774.7 3258.1000000000004 3945.3 3578.7 2051.3199999999997 4223.0 True False 3740.9730270515015 4959.3590287275465 2453.22013186295 2374.0907367151995 2523.7288749130726 3225.3264721181085 3647.702844620748 3483.7812507441176 3480.9402175149808 4765.063185503409 0.7850836140919469 1.0407750822308584 0.5148347537817125 0.49822859515017887 0.5296317754171503 0.6768696125437351 0.7655098584459554 0.7311091406600247 0.7305129191371329 1.0 12.218279629292171 -9.138841532519441 0.8204957161952011 1.0025231114686288 0.6803337205136589 0.2698081856218506 0.1520664709916088 3.428614284646544 3.2809332311090524 0.187454551580375 0.056910073986162955 7.263709508477615e-10 9.138841532519441 -0.3221893909549699 IPGGNIYIS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 IPGGNIYISPLK 12 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 IPGGNIYIS(1)PLK;IPGGNIYIS(1)PLK 107.74 0.0083558 36155000.0 67314.0 55600.0 75161.0 66888.0 75731.0 54222.0 62202.0 67246.0 50336.0 57007.0 True False 63572.95735929219 59864.34121782223 70325.2230891092 57777.7390117641 66216.99473626995 61690.588321690826 65094.51625092475 67441.67472682543 60404.60650535095 55361.05978802608 1.148333460427039 1.081343844338221 1.2703012434801635 1.0436530520367804 1.1960933369016153 1.1143317804590465 1.1758177408483046 1.218215023069559 1.0911027848208883 1.0 15.756583940593 -8.531419244697716 18.648380224098123 0.999999997094725 1.1542228102811602 0.37775016643360904 0.06241128252769955 30.952634129553477 67588.62937476944 0.05610765948949375 0.014486935385175613 2.9415806179144167e-09 8.531419244697716 0.15422281318643527 IPGGNIYIS(ph)PLKSPYK ddPTM_A459_Selumetinib_30min_R1 2 IPGGNIYISPLKSPYK 16 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 IPGGNIY(0.001)IS(0.998)PLKS(0.001)PYK;IPGGNIY(0.002)IS(0.997)PLKS(0.002)PYK 86.8 0.0083767 98486000.0 5904.4 7687.1 6377.3 7497.3 7036.4 6428.5 7158.4 7749.200000000001 3890.1 6042.7 True False 6041.9610320375505 6787.090758364165 5511.297688001409 6188.037296751097 6399.958862377318 6363.835126610989 6618.436124739096 7543.666043050923 6601.215578337376 6818.339405882416 0.8861338036098559 0.9954169709575778 0.8083049786648379 0.907557827263991 0.9386389385157115 0.933340913055852 0.9706815297327592 1.1063787813998731 0.9681559079681895 1.0 12.735204700947806 -7.353968637939077 2.506120888055383 1.0287602926403545 0.9094423015000491 0.4535816957784313 0.055374675798023285 0.2563886565160055 3.142848656869641 0.026707073082532423 0.016542406930520986 4.426203345110529e-08 7.353968637939077 -0.11931799114030539 IPGGNIYISPLKS(ph)PYK ddPTM_A459_Selumetinib_30min_R2 1 IPGGNIYISPLKSPYK 16 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 IPGGNIY(0.003)IS(0.113)PLKS(0.868)PY(0.016)K 60.334 0.040281 13775000.0 16834.0 16877.0 20903.0 20210.0 16876.0 12597.0 15159.0 18752.0 16921.0 21243.0 True False 15898.433671841294 18171.411631891835 19558.123737465594 17457.363135805408 14755.886006645793 14332.122405819398 15863.923536988637 18806.565215439292 20305.6728122426 20629.65939405754 0.7706590481285844 0.8808391493427267 0.9480584901512913 0.8462264355578296 0.715275309436097 0.69473383598121 0.76898620738054 0.9116275192045391 0.9842951075620634 1.0 14.332432381357433 -7.980848196300762 3.4969556602121483 0.9859487293243657 0.8064981469961158 0.5337483098091449 0.07161137799480287 0.22458631778649443 5.711388409394065 0.05767406493454685 0.022565869550162623 1.045085455531765e-08 7.980848196300762 -0.17945058232824995 IPGS(ph)PPESMGR ddPTM_A459_Selumetinib_30min_R1 2 IPGSPPESMGR 11 0 P50395-2;P50395;Q5SX87;V9GYJ7;V9GYF8;Q5SX90;Q5SX86 P50395-2 GDI2 Rab GDP dissociation inhibitor beta 1 IPGS(0.999)PPES(0.001)MGR;IPGS(0.939)PPES(0.061)MGR 96.067 0.020599 23140000.0 3571.6 3765.5 2988.4 3563.3 3787.5 2647.5 3522.0 3075.8 1355.94 2620.4 True False 3654.8113308761826 3324.633509466541 2582.591694106189 2941.036546425139 3444.921293737435 2620.8685537376673 3256.332704421532 2994.2197923935396 2300.931146060713 2956.7538648574787 1.2360891362366924 1.1244201111839234 0.8734550835636348 0.9946842655321608 1.165102491175229 0.8864006520420996 1.10132018194842 1.0126713041560078 0.7781950244179769 1.0 11.529798435888614 -5.026831958774912 4.969675557710719 0.9855483076758825 1.2158804115881352 0.3876817110537478 0.106166917631898 0.17324589827445525 11.71130571001831 0.026802744586410694 0.08809503322114745 9.400869873261573e-06 5.026831958774912 0.23033210391225267 IPGTPGAGGRLS(ph)PENNQVLTK ddPTM_A459_Selumetinib_30min_R1 2 IPGTPGAGGRLSPENNQVLTK 21 1 Q16514-2;Q16514 Q16514-2 TAF12 Transcription initiation factor TFIID subunit 12 1 IPGT(0.289)PGAGGRLS(0.71)PENNQVLT(0.001)K;IPGT(0.058)PGAGGRLS(0.915)PENNQVLT(0.026)K 56.017 0.017075999999999997 217875000.0 4077.6 3706.3999999999996 4944.6 5641.9 4506.6 3621.8999999999996 3167.7 3539.1 2072.6499999999996 3231.1 True False 4172.600146371574 3272.452964941385 4273.150478743631 4656.648076579569 4098.978825704853 3585.466974422083 2928.757838670097 3445.231571383049 3517.1356696334155 3645.8431585792246 1.1444815272847955 0.8975846800323278 1.1720609726966056 1.2772486017731635 1.124288305178277 0.9834397198313187 0.8033142708781325 0.9449752557994422 0.9646974695982353 1.0 11.832036783722359 -6.868472258014606 4.15216820733022 0.9203429515682283 1.1218280749988443 0.46121794248257786 0.10031544312380758 0.21401533661433203 6.681852701679463 0.039089017195534176 0.03449898558631461 1.3537165609978945e-07 6.868472258014606 0.20148512343061598 IPGTPGAGGRLS(ph)PENNQVLTK ddPTM_A459_Selumetinib_30min_R2 2 IPGTPGAGGRLSPENNQVLTK 21 1 Q16514-2;Q16514 Q16514-2 TAF12 Transcription initiation factor TFIID subunit 12 1 IPGTPGAGGRLS(1)PENNQVLTK;IPGTPGAGGRLS(1)PENNQVLTK 94.72 0.00024057 119875000.0 183089.0 155399.0 185466.0 189389.0 204357.0 131297.0 110081.0 128909.0 91025.0 171536.0 True False 172913.6463433379 167317.6036134599 173533.31948011275 163593.89148575228 178683.84668524005 149381.9699545027 115199.98462136342 129284.10384796638 109232.54345100088 166583.30997594792 1.0380010240419881 1.0044079664260364 1.041720923333606 0.9820545138007687 1.072639550210878 0.8967403155578502 0.6915457775331546 0.776092778241908 0.6557232142089888 1.0 17.345884338398896 -7.001790727246455 4.191001751333661 0.7636478516533269 1.0235275048903694 0.6310830876057878 0.08854704385495055 0.12094463592678964 5.061261446096621 0.03129544781044078 0.025747246528318998 9.958851872740562e-08 7.001790727246455 0.25987965323704243 IPMPPS(ph)SPQPR ddPTM_A459_Selumetinib_30min_R2 1 IPMPPSSPQPR 11 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 IPMPPS(0.867)S(0.133)PQPR 142.89 0.00088397 2690300.0 12233.0 12977.0 14606.0 14096.0 12439.0 11018.0 10886.0 16212.0 9352.5 13500.0 True False 11553.138832578987 13972.294172368322 13666.265861810387 12176.100483043701 10876.301613929068 12535.629488554272 11392.220570199775 16259.174235958926 11223.261330683696 13110.219922787592 0.8812315049343942 1.0657558953745934 1.0424131663921443 0.9287487589647336 0.8296048180720731 0.9561723268093625 0.8689572438367973 1.2401908077604378 0.8560696461831224 1.0 13.678404266394688 IPMTPTSSFVS(ph)PPPPTAS(ph)PHSNR ddPTM_A459_Selumetinib_30min_R2 1 IPMTPTSSFVSPPPPTASPHSNR 23 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 2 IPMTPT(0.001)S(0.004)S(0.056)FVS(0.939)PPPPT(0.272)AS(0.694)PHS(0.034)NR 87.73899999999998 0.00090421 3183400.0 6243.6 4446.2 7185.4 5359.8 7886.5 5617.7 5637.4 3996.3 4431.9 5901.6 True False 5896.605707111108 4787.209243213691 6723.099186871991 4629.785993829285 6895.727363795456 6391.4871825967775 5899.550270296178 4007.928571376921 5318.403837632408 5731.205473801724 1.0288595888012488 0.8352883638698361 1.1730689499101672 0.807820626043298 1.203189694614327 1.1152081724888958 1.0293733660857187 0.6993168522220703 0.9279729826375446 1.0 12.484622904999009 -7.697516999013393 24.99827153611854 0.8602328816867698 1.0274236979879707 0.19640791579755978 0.13963425960255618 85.84572828826727 33571.196050733226 0.06380851910939404 0.036839842159791726 2.0067025427825444e-08 7.697516999013393 0.16719081630120092 IPMTPTSSFVSPPPPT(ph)ASPHSNR ddPTM_A459_Selumetinib_30min_R1 1 IPMTPTSSFVSPPPPTASPHSNR 23 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 IPMTPTSSFVSPPPPT(0.494)AS(0.494)PHS(0.011)NR 99.836 6.919100000000001e-05 55646000.0 1337.9 1380.1 1545.9 1458.0 1149.4 1185.9 1244.2 1704.8 1182.7 1428.5 True False 1369.0704668997773 1218.517250408916 1335.9752710208663 1203.387670049631 1045.4369729430523 1173.970922711048 1150.3489922888325 1659.5831660291658 2006.9555190096958 1611.86188976832 0.8493720681593632 0.7559687701184242 0.828839790494018 0.746582370169816 0.6485896710997476 0.728332203995336 0.7136771454123636 1.0296063059519975 1.2451163041631093 1.0 10.65451241842724 -7.865038643547717 4.294194039645056 1.1263763331023224 0.7509280568413232 0.8036869414296981 0.07732865253958174 0.08690400154860385 2.8151056887244503 0.04515708963842787 0.020631377728062582 1.3644617213056182e-08 7.865038643547717 -0.3754482762609992 IPMTPTSSFVSPPPPT(ph)ASPHSNR ddPTM_A459_Selumetinib_30min_R2 1 IPMTPTSSFVSPPPPTASPHSNR 23 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 IPMTPTSSFVSPPPPT(0.66)AS(0.314)PHS(0.026)NR 104.96 2.9767e-05 43170000.0 9255.6 8940.4 10172.0 10646.0 14569.0 9956.1 12268.0 12620.0 10311.0 9270.6 True False 8741.210805102435 9626.099932083056 9517.544594436213 9195.996434625647 12738.71197148747 11327.462402522708 12838.486308580823 12656.72211064653 12373.48811341135 9002.933690088494 0.9709291555402442 1.069218130827801 1.0571603570638606 1.021444425915266 1.4149512159032969 1.258196804780794 1.426033640869194 1.4058441999390225 1.3743840107401397 1.0 13.136179478380003 -6.253695781166015 24.72787846800157 1.3364152144054449 1.034473884954242 0.565544412139612 0.1206997300089525 338.90421174928275 1082232.7338984308 0.03366377296446767 0.04261398389551748 5.575761885726145e-07 6.253695781166015 -0.3019413294512028 IPMTPTSSFVSPPPPTAS(ph)PHSNR ddPTM_A459_Selumetinib_30min_R1 1 IPMTPTSSFVSPPPPTASPHSNR 23 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 IPMTPTSSFVSPPPPT(0.17)AS(0.823)PHS(0.007)NR 157.2 1.2082e-09 47248000.0 1675.6 2000.9 1248.9 1398.3 1799.2 1223.5 1902.3 1661.4 825.79 1661.1 True False 1714.6382198499623 1766.6336978068273 1079.3062397166445 1154.1131543418373 1636.46267767456 1211.1927008491161 1758.807979449483 1617.3342750122333 1401.3053166847171 1874.3183654841844 0.9148062844739973 0.9425472909723427 0.5758393342306243 0.6157508647383394 0.8730974992350458 0.6462043605576229 0.9383720566570546 0.8628919743815424 0.7476346294684704 1.0 10.872150309855058 -7.277847098876746 24.853093365339305 0.8757989898157492 0.7596350778541031 0.1774523828418414 0.1317925494692981 1624.8204610984549 2461136.465074963 0.05781149582698257 0.03910731363166484 5.2741551478443585e-08 7.277847098876746 -0.1161639119616461 IPMTPTSSFVSPPPPTAS(ph)PHSNR ddPTM_A459_Selumetinib_30min_R2 3 IPMTPTSSFVSPPPPTASPHSNR 23 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 IPMTPTSSFVS(0.009)PPPPT(0.325)AS(0.617)PHS(0.049)NR;IPMTPTSSFVSPPPPT(0.312)AS(0.663)PHS(0.025)NR;IPMTPTSSFVSPPPPT(0.478)AS(0.488)PHS(0.033)NR 107.29 1.2765e-05 70239000.0 46430.0 43698.0 55904.0 57358.0 59712.0 44854.0 52856.0 54992.0 52086.0 50410.0 True False 43849.60647401639 47049.49608878411 52307.197503673015 49545.741451931084 52210.444727947026 51032.23135592791 55313.90873217707 55152.017615584344 62504.65540443633 48954.53231909056 0.8957210782486952 0.9610856004529011 1.0684852867703738 1.0120766986187706 1.0665089064202289 1.0424414030409828 1.1299037313161415 1.1265967624018538 1.276789960876854 1.0 15.579154813465859 -4.478885858036458 0.41869298074367467 1.1370411199798973 0.6705159057901737 0.5039014307428357 0.07021165991765858 5.707600718567817 0.6484480317052699 0.05355219767658765 1.4012767369657235 3.3198169804341774e-05 4.478885858036458 -0.4665252141897236 IPNYQLS(ph)PTKLPSINK ddPTM_A459_Selumetinib_30min_R1 1 IPNYQLSPTKLPSINK 16 1 O60934;A0A0C4DG07 O60934 NBN Nibrin 1 IPNY(0.074)QLS(0.83)PT(0.096)KLPSINK 102.47 0.0027085 314490000.0 6104.0 7044.2 8212.2 8001.7 6664.9 5523.4 6742.8 6315.7 3624.5 5801.0 True False 6246.211323683562 6219.461789240264 7097.028346385639 6604.353305511754 6062.06097178367 5467.839610845942 6234.1851673405745 6148.187119715157 6150.511776993862 6545.614856525048 0.9542589138829299 0.9501722795438147 1.0842416643733492 1.0089737099224763 0.9261255213848484 0.8353439257727305 0.9524216294403539 0.9392833606129893 0.9396385078878688 1.0 12.676313001476773 -6.26528889248045 23.239520322624294 0.9252743790243895 1.0019538364367906 0.2841554140642275 0.051563924779880276 153.88320852710368 928993.7122103721 0.0163903257185687 0.01932692227480699 5.4288908179813e-07 6.26528889248045 0.07667945741240112 IPNYQLS(ph)PTKLPSINK ddPTM_A459_Selumetinib_30min_R2 3 IPNYQLSPTKLPSINK 16 1 O60934;A0A0C4DG07 O60934 NBN Nibrin 1 IPNY(0.082)QLS(0.669)PT(0.248)KLPS(0.001)INK;IPNY(0.001)QLS(0.983)PT(0.016)KLPSINK;IPNY(0.116)QLS(0.831)PT(0.052)KLPSINK 97.129 0.021203 277374000.0 174223.0 163484.0 180278.0 178219.0 168500.0 128015.0 136711.0 158341.0 115247.0 158717.0 True False 164540.38312992777 176022.69711608757 168679.10975184556 153945.26475507655 147331.52359088743 145647.90424553215 143068.3323877073 158801.74609523642 138299.6202702279 154134.4278137094 1.067512206479887 1.1420076592416646 1.094363615867282 0.9987727397355932 0.9558638240702193 0.9449407657422632 0.9282049079951377 1.0302808291939038 0.8972662514917185 1.0 17.23382961590419 -5.836325587669846 2.892165330070186 0.9593605216451637 1.1087840085214122 0.7341044933111684 0.03820155168206093 0.1209461431812512 2.0450039493373247 0.010673738710432699 0.017792931653311063 1.4577210068301255e-06 5.836325587669846 0.1494234868762485 IPNYQLSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 2 IPNYQLSPTK 10 0 O60934;A0A0C4DG07 O60934 NBN Nibrin 1 IPNYQLS(0.087)PT(0.913)K;IPNYQLS(0.155)PT(0.845)K 140.63 0.0032677 64292000.0 85744.0 68269.0 81331.0 72666.0 87275.0 65682.0 89866.0 84528.0 74434.0 63625.0 True False 80978.69174042768 73505.01278056676 76098.25200649738 62768.76544415812 76310.7342516005 74729.09929816863 94044.94706610081 84773.96248563638 89322.8798597285 61787.9809323971 1.3105897056100173 1.1896328650225583 1.2316028272514246 1.01587338665159 1.2350417200894281 1.2094439431502146 1.522058912541525 1.3720137995508948 1.4456351949330994 1.0 15.915038610306915 -7.075188254797986 12.480325471596391 1.3660195042265815 1.1914819804861407 0.1602265958578981 0.14602359040209714 1.7249534110926257 283.9435209870223 0.05293630194756241 0.041009046812506146 8.410304988655613e-08 7.075188254797986 -0.17453752374044074 IPNYQLSPT(ph)KLPSINK ddPTM_A459_Selumetinib_30min_R1 1 IPNYQLSPTKLPSINK 16 1 O60934;A0A0C4DG07 O60934 NBN Nibrin 1 IPNY(0.179)QLS(0.226)PT(0.587)KLPS(0.008)INK 79.462 0.03411 359150000.0 6055.8 6459.0 6966.4 7393.8 6397.0 6441.3 6270.6 6315.6 3287.0 5545.9 True False 6196.8883574644315 5702.777277292363 6020.4011436960745 6102.611628815478 5818.392479482081 6376.506370232458 5797.603593510978 6148.089772040005 5577.798927018575 6257.770286640624 0.9902709868871079 0.911311380263816 0.9620680958118107 0.9752054404815105 0.9297868430714775 1.0189741837991908 0.9264647514927111 0.9824729081483272 0.8913396739612377 1.0 12.61143298504229 -4.416218997077579 21.284925962211943 0.9555712920207247 7.4571940849568294 0.0694657196543097 0.03839519648727155 1108.2161052349559 218742.23317467104 0.00853011579137022 3832.442594097078 3.835138062803655e-05 4.416218997077579 6.501622792936105 IPPIIEESSS(ph)PPYR ddPTM_A459_Selumetinib_30min_R1 1 IPPIIEESSSPPYR 14 0 A0A5H1ZRR2;Q6P9H4 A0A5H1ZRR2 CNKSR3 Connector enhancer of kinase suppressor of ras 3 1 IPPIIEES(0.128)S(0.128)S(0.744)PPYR 143.56 0.00053694 3793200.0 575.63 969.16 802.83 871.67 610.78 689.15 482.47 658.55 449.91 651.93 True False 589.0410590189986 855.6902966497395 693.8100956295247 719.4491977724019 555.5350568419675 682.2177766981353 446.0768994611748 641.0831147281243 763.4644098737228 735.6115658359544 0.8007501327818412 1.1632365998450918 0.9431745337514831 0.9780286651078067 0.7552016344531688 0.9274157835227318 0.6064027812752641 0.8714967851267982 1.0378635210909393 1.0 9.522800352834798 -6.1643783764540805 9.076649498013197 0.8501034543353154 0.9836139955549029 0.10808449040457946 0.1413891787203506 0.6873812821562404 59.522495360168314 0.0410608886231155 0.0530765069704668 6.848912590500393e-07 6.1643783764540805 0.1335105412195875 IPS(ph)LPPS(ph)T(ph)QTLY(ph)WR ddPTM_A459_Selumetinib_30min_R2 1 IPSLPPSTQTLYWR 14 0 A0A2R8Y709 A0A2R8Y709 4 IPS(1)LPPS(0.986)T(0.997)QT(0.039)LY(0.977)WR 78.501 0.012528 5075000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 IPS(ph)PIGFTPGPQQLLGDPFQGMR ddPTM_A459_Selumetinib_30min_R1 2 IPSPIGFTPGPQQLLGDPFQGMR 23 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B0QYZ7;H7C0J7 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 IPS(1)PIGFTPGPQQLLGDPFQGMR;IPS(0.999)PIGFT(0.001)PGPQQLLGDPFQGMR 101.71 2.6195e-05 7044300.0 299.852 519.45 602.17 698.1 363.51 373.34000000000003 346.21000000000004 230.9 63.462 300.31 True False 306.8379681895744 458.63255251424664 520.3986214830425 576.1899399599776 330.63058468290313 369.58453856559805 320.09510096473014 224.7757819310971 107.6903789189086 338.8577137671156 0.9055068122204613 1.3534664665460379 1.5357437660123423 1.7003890321823147 0.9757209921747076 1.0906776607115984 0.9446298194194855 0.6633338206536363 0.31780412410183534 1.0 8.404535803153681 -7.167418991765866 1.2190277742207498 0.6284389861775067 1.3536079004596926 0.5184618836295095 0.2668069342079661 0.3700338503865068 1.089840618134819 0.17166148677637294 0.10666093692391448 6.80112893509955e-08 7.167418991765866 0.7251689142821859 IPS(ph)PLQPEMQGTPDDEPSEPEPSPSTLIYR ddPTM_A459_Selumetinib_30min_R1 1 IPSPLQPEMQGTPDDEPSEPEPSPSTLIYR 30 0 Q96GY3;K7EMY4 Q96GY3 LIN37 Protein lin-37 homolog 1 IPS(0.999)PLQPEMQGT(0.001)PDDEPSEPEPSPSTLIYR 100.77 2.6941000000000006e-08 3335200.0 207.6 386.71 232.32 345.99 254.55 242.83 440.31 316.74 219.05 203.18 True False 212.4366760807187 341.43381342339853 200.77222004241403 285.5693415366749 231.52599744445263 240.38735067199926 407.0970622043853 308.33902628348073 371.71185122099774 229.26013214079617 0.926618483977207 1.4892855998779273 0.8757397902881484 1.2456127407328608 1.0098833813035792 1.0485353403022968 1.775699326363354 1.3449308582537134 1.6213540825873611 1.0 7.840841684843751 -7.230794070639922 24.9284131060395 1.464240395754324 1.1094339436964218 0.30269932057649507 0.2481795165089917 736.1899548220439 598854.1737613209 0.08795421332994294 0.06812097028636473 5.8776798833760086e-08 7.230794070639922 -0.3548064520579022 IPS(ph)PNILK ddPTM_A459_Selumetinib_30min_R1 2 IPSPNILK 8 0 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 IPS(1)PNILK;IPS(1)PNILK 90.149 0.028672000000000007 152150000.0 12994.1 13967.2 15941.900000000001 17674.3 15519.2 12661.400000000001 14633.7 14145.6 8137.9 11690.0 True False 13296.837247882786 12331.913730824883 13777.077542588491 14587.815292701098 14115.491100137304 12534.037811631393 13529.868227340543 13770.412736615526 13809.421931300414 13190.525370242685 1.0080597151861697 0.9349069415116098 1.0444676884265007 1.1059313320158304 1.0701234942454456 0.9502303706498073 1.025726257868652 1.0439624162113395 1.0469197809553465 1.0 13.687214406909888 -5.278704402034317 24.44089414492789 1.0377877858000424 0.9714833275834878 0.2712800175978145 0.042155243370851976 714.2515865332126 1011116.1864201324 0.011715582765155287 0.024483406695794244 5.2637541637542635e-06 5.278704402034317 -0.06630445821655462 IPSAS(ph)PQTQR ddPTM_A459_Selumetinib_30min_R2 1 IPSASPQTQR 10 0 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 IPS(0.001)AS(0.999)PQTQR 134.75 0.002048 8255500.0 7753.9 6322.7 5304.1 5687.0 8141.3 5562.7 5564.3 6397.7 5395.5 7277.7 True False 7322.969279321035 6807.630759315195 4962.839980667431 4912.420789377803 7118.517109854548 6328.9114318370675 5823.050975451275 6416.316247803748 6474.750762865957 7067.573891264538 1.036136217602502 0.9632203163421282 0.7021985276731891 0.695064652305866 1.0072080206551466 0.8954857111093736 0.8239108731001054 0.9078527294541994 0.9161207031551087 1.0 12.78699934612903 IPSFFPSPEEPPS(ph)PSAPSIAK ddPTM_A459_Selumetinib_30min_R1 1 IPSFFPSPEEPPSPSAPSIAK 21 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 IPSFFPSPEEPPS(0.954)PS(0.038)APS(0.008)IAK 76.19800000000002 0.0018957 5282400.0 1148.7 1045.2 1124.8 1459.2 1411.8 1197.6 1034.3 735.17 631.45 955.22 True False 1175.4624750188912 922.827498099703 972.0583380841392 1204.3781125764215 1284.102939273534 1185.5532313337985 956.2819182802929 715.670903431289 1071.5245307167258 1077.8317916307278 1.09058063061997 0.8561887905565414 0.9018646004247505 1.1174082281932256 1.191376009915911 1.0999427188356463 0.8872274186990406 0.6639912730246155 0.9941481955134583 1.0 10.073916330734674 -7.365446333243892 5.929460048523646 0.8546474464961701 1.0376806356139592 0.2508222106815139 0.128579342357915 0.31772899556590295 15.228239362184143 0.05804106266300586 0.03873110525524443 4.310758237330471e-08 7.365446333243892 0.1830331891177891 IPSIVS(ph)SPLNSPLDR ddPTM_A459_Selumetinib_30min_R2 3 IPSIVSSPLNSPLDR 15 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IPSIVS(0.922)S(0.077)PLNSPLDR;IPSIVS(0.498)S(0.498)PLNS(0.004)PLDR;IPS(0.003)IVS(0.612)S(0.383)PLNS(0.003)PLDR 159.12 0.00011182 20961000.0 43249.4 32283.4 44788.66 49389.5 51209.0 47399.22 41407.86 39660.4 36295.8 37304.0 True False 40845.77148906578 34759.43297250796 41907.00637780584 42662.564898360266 44775.667605731476 53928.03230772112 43333.40753811798 39775.80519786732 43555.97418938568 36226.93659256802 1.1274972528989746 0.9594913686309011 1.156791335936561 1.1776475990275292 1.2359771986604364 1.48861696240649 1.1961653844892826 1.0979621502422965 1.2023090629838467 1.0 15.144775193909027 -5.527028933778634 3.0830616075568864 1.2172789257130665 1.0433011073749483 0.1860147622513364 0.12360951147693376 0.37067415394797937 7.18499831815877 0.03555165421891175 0.07544479346663781 2.971468058550178e-06 5.527028933778634 -0.1739778183381182 IPSIVSS(ph)PLNSPLDR ddPTM_A459_Selumetinib_30min_R1 2 IPSIVSSPLNSPLDR 15 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IPSIVS(0.055)S(0.945)PLNSPLDR;IPSIVS(0.172)S(0.8)PLNS(0.028)PLDR 173.19 3.3961e-05 56192000.0 484.56 660.34 639.55 603.01 530.37 510.01 562.74 518.32 392.81 504.92 True False 495.84930521037154 583.0270858162623 552.7026227966851 497.70562339960804 482.3981271444285 504.8797624520292 520.2920687354268 504.57246985935996 666.5698802927183 569.7314003372909 0.8703211810281479 1.0233367609211994 0.9701108671024197 0.8735794149751228 0.8467114974860792 0.886171557602638 0.9132234390230288 0.8856321936278118 1.169972165652266 1.0 9.154138111276428 -8.248960418977301 24.95127755123444 1.0849860859231049 0.910679804116748 0.5604386064517788 0.062450482793330965 486.14547721574496 972036.9024657645 0.04398074922028679 0.0163646470615777 5.6368902735479536e-09 8.248960418977301 -0.17430628180635688 IPSIVSS(ph)PLNSPLDR ddPTM_A459_Selumetinib_30min_R2 1 IPSIVSSPLNSPLDR 15 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IPSIVS(0.009)S(0.991)PLNSPLDR 208.38 1.6281e-06 20771000.0 17228.0 17853.0 17887.0 21565.0 27043.0 22055.0 25384.0 22160.0 21684.0 22140.0 True False 16270.536729148265 19222.267693557194 16736.169893893075 18627.809798300033 23645.616572512583 25092.87605464371 26564.406297441757 22224.481931214512 26021.405901581955 21500.760673371646 0.7567423765289881 0.894027331663836 0.7783989668151862 0.8663791054318503 1.099757210069191 1.1670692230773418 1.2355100687363754 1.033660262947775 1.2102551298945 1.0 14.392100081238047 -6.250382671089189 3.306417728542883 1.1380657375021974 0.8182153323551165 0.7939565935723841 0.07539175615394234 0.1025365343484281 2.3523033401394713 0.022626090740550848 0.028327688170117004 5.618460460699538e-07 6.250382671089189 -0.31985040514708096 IPSLGWS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 IPSLGWSPSK 10 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 IPSLGWS(0.997)PS(0.003)K;IPSLGWS(0.997)PS(0.003)K 162.49 0.00040797 172117000.0 13342.400000000001 8801.9 11584.0 11951.400000000001 9990.4 7643.299999999999 8009.400000000001 7966.9 5357.0 7602.0 True False 13653.251960208965 7771.369456107703 10010.956426357283 9864.312345563209 9086.770083948379 7566.415341561143 7405.244509595062 7755.5919318616625 9090.437740200336 8577.79074975063 1.5916979509678395 0.9059872970594006 1.1670786474534038 1.1499828607791558 1.0593368792789153 0.8820937188029576 0.8633044015220754 0.9041479511594673 1.0597644551383594 1.0 13.066390407352834 -4.755869581477668 24.9999607604028 1.0000322705650548 1.5916988907508232 0.7451200576442212 0.1039793261761051 100.80681427582205 452422.82513396716 0.028986457502578878 0.24704514024948884 1.754407270800209e-05 4.755869581477668 0.5916666201857683 IPSLGWS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 IPSLGWSPSK 10 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 IPS(0.003)LGWS(0.957)PS(0.04)K;IPSLGWS(0.996)PS(0.004)K 145.14 0.00091257 80536000.0 183874.0 158627.0 182166.0 181314.0 160202.0 120564.0 145392.0 125402.0 100799.0 129363.0 True False 173655.01918594213 170793.1808338036 170445.63788734458 156618.72041590427 140075.99253594852 137170.59662897603 152153.01608878243 125766.8990585812 120961.61655937806 125627.95406456084 1.3822960063227643 1.3595157391963268 1.3567492932325533 1.246686866646074 1.1150065570912886 1.0918795713132714 1.2111398073918345 1.0011060037955324 0.9628558982757554 1.0 16.938797995219403 -6.162868575556946 0.4638524132423504 0.9809638480071183 1.4725539136003 0.8639918050765097 0.05627219129541828 0.5834206731021109 0.22592546692617282 0.05250551256349912 0.1379464518588563 6.872763893549589e-07 6.162868575556946 0.49159006559318175 IPSTENSSQEISVEERT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 4 IPSTENSSQEISVEERTPTK 20 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 IPSTENSSQEIS(0.003)VEERT(0.771)PT(0.226)K;IPSTENSSQEISVEERT(0.813)PT(0.187)K;IPSTENSSQEISVEERT(0.848)PT(0.152)K;IPSTENSS(0.001)QEISVEERT(0.92)PT(0.078)K 131.32 0.00021749 111456000.0 6747.2 7118.1 7511.4 8437.6 7013.799999999999 7003.15 6351.08 6035.33 3891.79 5532.34 True False 6904.396632234227 6284.70954288509 6491.39313716679 6964.131553368151 6379.403028386965 6932.704669351447 5872.012922316157 5875.253442885263 6604.083384904662 6242.469728555042 1.106036061440766 1.006766522893468 1.0398757894608754 1.1156051781095546 1.0219357571259893 1.1105708110427914 0.9406554100624152 0.9411745187982227 1.0579279791611138 1.0 12.607901204809261 -7.264868285324096 24.99979591329691 0.9800373536981811 1.0630251640126447 0.4218579415030279 0.04668101299225507 291.92178080465607 2128357.494342951 0.0185606126622269 0.013108835610677319 5.434151157483547e-08 7.264868285324096 0.08298781031446356 IPSTENSSQEISVEERT(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 IPSTENSSQEISVEERTPTK 20 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 IPSTENSSQEISVEERT(0.986)PT(0.014)K;IPSTENSSQEIS(0.001)VEERT(0.885)PT(0.114)K 128.51 0.00026237 42912700.0 50984.0 56258.0 56924.0 56990.0 53324.0 45244.0 43575.0 42028.0 38054.0 52665.0 True False 48150.51338512281 60572.807702018756 53261.57181416505 49227.86368676649 46624.96239739159 51475.95031586038 45601.32384222446 42150.294521890064 45665.86331759821 51144.42460989692 0.9414616305176935 1.184348209292345 1.0413954643231715 0.9625264935963409 0.9116333354617352 1.0064821475359662 0.8916186698755074 0.8241425110046812 0.8928805762488027 1.0 15.642289356058406 -5.8342149807620896 2.6834107322137957 0.9158702510730685 1.0728863582006565 0.3950664436522022 0.07408340131388683 0.24824862278766247 3.628243755983833 0.022046867884430874 0.03737923428897203 1.4648225574503171e-06 5.8342149807620896 0.15701610712758796 IPVEGPLS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 IPVEGPLSPSR 11 0 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 IPVEGPLS(0.68)PS(0.32)R 100.02 0.016677 16320000.0 1649.4 1958.3 1073.8 1426.7 1615.3 1270.1 1714.1 1738.3 623.92 1387.0 True False 1687.8278108262882 1729.0213256110294 927.9838579611921 1177.5536274758635 1469.196400204377 1257.3239471585318 1584.8040569701725 1692.1946372058298 1058.7466706861665 1565.034960524089 1.0784601324567722 1.104781279155595 0.5929476857503776 0.7524136247292085 0.9387626712903472 0.8033839363802373 1.0126317283285884 1.0812503745214475 0.6765003321916976 1.0 10.611979169814472 -10.421865087241072 17.879110914777414 0.9999999999999982 0.8943990174873122 0.03335877683609212 0.17198722818590978 0.0 0.0 0.17166136369048857 0.041633996137261924 3.785601654520278e-11 10.421865087241072 -0.10560098251268601 IPVEGPLS(ph)PSRGDFPK ddPTM_A459_Selumetinib_30min_R1 2 IPVEGPLSPSRGDFPK 16 1 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 IPVEGPLS(0.988)PS(0.012)RGDFPK;IPVEGPLS(0.981)PS(0.019)RGDFPK 97.823 0.010743 28293800.0 3721.05 3629.4 5311.5 6114.0 4682.3 4386.0 4502.1 4046.7 2408.34 2781.8900000000003 True False 3807.743225097102 3204.4681607377147 4590.227473981069 5046.304673994134 4258.786791727206 4341.880822169371 4162.502972338493 3939.368370465876 4086.777081805873 3138.972679403285 1.2130539555447641 1.0208652600783006 1.4623343185177597 1.6076293709422889 1.3567454153620722 1.3832171431943643 1.3260717430423066 1.2549865108143425 1.3019473245567605 1.0 11.616076756888607 -9.162822063717327 0.8864891868387719 0.9980481058951098 1.3407143298577404 0.3141462179722465 0.14552683291308793 3.4084547903458673 3.588314683202419 0.17371615375476016 0.052287904684233354 6.873499988580812e-10 9.162822063717327 0.3426662239626306 IPVEGPLSPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 IPVEGPLSPSR 11 0 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 IPVEGPLS(0.173)PS(0.827)R 96.23 0.020438 14507000.0 1426.4 1539.0 1284.4 1312.8 1767.1 1427.5 1492.6 1685.1 591.54 1358.4 True False 1459.6323447087534 1358.81316453831 1109.9855347041857 1083.544124308063 1607.266117006844 1413.140646066297 1380.011980300846 1640.405674023783 1003.8001756277959 1532.7638719364984 0.9522878059910491 0.8865117383159491 0.7241725584918874 0.7069217536678433 1.0486064725522395 0.9219558680496109 0.9003421894054268 1.070227256825469 0.6548955086993222 1.0 10.581919746156546 -6.2597465123100235 24.99286886596775 0.9340303574623322 0.8157404244817263 0.1666880671370028 0.12613729978893823 283.0254443342936 4178479.884012606 0.03776498754526153 0.04623822035211853 5.498617218398558e-07 6.2597465123100235 -0.11828993298060586 IPVEGPLSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 IPVEGPLSPSR 11 0 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 IPVEGPLS(0.367)PS(0.633)R;IPVEGPLS(0.04)PS(0.96)R;IPVEGPLS(0.122)PS(0.878)R 115.37 0.0061963 28437400.0 25951.2 23677.5 30731.5 27824.6 32322.6 24126.9 23187.6 27344.8 31550.0 27891.6 True False 24508.93619488463 25493.488114837877 28754.268747927294 24034.84147988773 28261.94602028971 27450.161472808144 24265.86934535774 27424.368840824678 37860.881580654415 27086.297036920183 0.9048463199483318 0.9411950286186695 1.0615799091597338 0.8873431996675979 1.0434038282075637 1.0134335245379607 0.895872525959601 1.0124812854058154 1.3977872844356634 1.0 14.725275555975164 -8.02635216920985 23.722500570267066 1.2009740541589171 0.9677975736694948 0.4335818379974691 0.10584742074174058 330.06677298390736 297126.2302756551 0.06480224130952184 0.024708590331550442 9.411261282412704e-09 8.02635216920985 -0.2331764804894223 IPVLS(ph)PKPAVAPPAPPSSSQLCR ddPTM_A459_Selumetinib_30min_R2 2 IPVLSPKPAVAPPAPPSSSQLCR 23 1 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V411;Q6PJT7-8 Q6PJT7-5 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 IPVLS(1)PKPAVAPPAPPSSSQLCR;IPVLS(1)PKPAVAPPAPPSSSQLCR 57.826 0.008403200000000001 22149000.0 28084.0 20403.6 24270.0 20926.2 24717.0 21876.9 30411.0 31573.0 29459.0 22788.0 True False 26523.203709159516 21968.490512085562 22708.494623178027 18076.015460291495 21611.829487216408 24890.244396274553 31825.1717582533 31664.872202808463 35351.62315323295 22130.051229665463 1.1985152421881882 0.9926994874117901 1.0261383666720643 0.816808568254035 0.9765828945865983 1.124726017936598 1.4380975185268197 1.4308539946062808 1.597448771643325 1.0 14.433719170439787 -7.106615750723394 3.2928574804582262 1.4027052385018228 0.9949183432067711 0.5096726655976404 0.16684375060503243 0.18766537460883817 3.824239461962876 0.06622924316530976 0.05050660934395692 7.823196688315445e-08 7.106615750723394 -0.40778689529505174 IPVLS(ph)PKPVAPPAPPSSSQLCR ddPTM_A459_Selumetinib_30min_R2 2 IPVLSPKPVAPPAPPSSSQLCR 22 1 Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11;Q6PJT7-6 Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 IPVLS(1)PKPVAPPAPPSSSQLCR;IPVLS(1)PKPVAPPAPPSSSQLCR 81.94 0.00053877 14991000.0 46008.0 33939.0 43116.0 44854.0 45213.0 39011.0 57044.0 54800.0 48999.0 40932.0 True False 43451.059544616546 36542.0121689149 40341.96350115136 38744.80782253421 39532.93873065157 44384.41114340086 59696.65903054165 54959.4589273716 58800.1691464497 39750.186805892 1.093103279156816 0.9192915833919663 1.0148873940680863 0.9747075658218349 0.9945346653010388 1.116583712175711 1.5017956851889074 1.3826213998879922 1.4792425865463856 1.0 15.278674019903693 -7.0676788160142765 4.296941264743166 1.3711218551340374 0.9978595567317898 0.5815943374276908 0.1355984118929596 0.13943614509713106 4.990824448138299 0.049561601976491176 0.03876041239252552 8.55699314321163e-08 7.0676788160142765 -0.37326229840224756 IPYPGRS(ph)PQDLASTSR ddPTM_A459_Selumetinib_30min_R2 1 IPYPGRSPQDLASTSR 16 1 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 IPY(0.001)PGRS(0.998)PQDLAS(0.001)TSR 64.346 0.032222 8002100.0 10931.0 17403.0 19563.0 15249.0 17380.0 11453.0 10693.0 14046.0 9253.0 19221.0 True False 10323.498780260023 18737.75414053526 18304.33787858392 13172.059894007749 15196.569020828621 13030.546790017428 11190.245687777535 14086.871534559517 11103.858550421404 18666.03978784448 0.5530631509198215 1.0038419693467857 0.9806224612520057 0.7056697641127677 0.8141292525651203 0.698088450368731 0.599497580363283 0.7546791764438987 0.5948695425824794 1.0 14.188128255454549 -5.793854964408955 24.997202664091265 0.723633098618506 0.861642607668581 0.08193496993789984 0.15751036576616248 362.48322622868136 279526.6592124691 0.04298764610638786 0.06376618015206274 1.6074779915740365e-06 5.793854964408955 0.13800950905007503 IPYQS(ph)PVSSSESAPGTIMNGHGGGR ddPTM_A459_Selumetinib_30min_R2 3 IPYQSPVSSSESAPGTIMNGHGGGR 25 0 Q5T6F2;H0YDN2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 IPY(0.001)QS(0.447)PVS(0.314)S(0.099)S(0.136)ES(0.003)APGTIMNGHGGGR;IPYQS(0.987)PVS(0.01)S(0.001)S(0.002)ESAPGTIMNGHGGGR;IPY(0.021)QS(0.972)PVS(0.003)S(0.001)S(0.002)ESAPGTIMNGHGGGR 112.35 9.2246e-08 30918600.0 63067.0 65938.0 78248.0 91456.0 91778.0 65118.0 61787.0 65065.0 53186.0 77719.0 True False 59561.98861720423 70995.2325759131 73213.60886998066 78999.53502960037 80248.02713426981 74087.41341765082 64660.21792861781 65254.328377909354 63824.68614100435 75475.05053178722 0.7891612949913692 0.9406450486046726 0.9700372289137571 1.0466973453211375 1.0632391309293976 0.9816146249077108 0.8567098328922004 0.8645814466918007 0.8456395284442217 1.0 16.203712197196722 -7.255729316392498 24.350717684348993 0.8804478217786624 0.9724910388598778 0.1578351106462912 0.08048266407021332 530.4414978148083 2262087.5354561494 0.03306970740598911 0.02487454633125827 5.549715034067796e-08 7.255729316392498 0.09204321708121532 IPYQSPVS(ph)SSESAPGTIMNGHGGGR ddPTM_A459_Selumetinib_30min_R1 2 IPYQSPVSSSESAPGTIMNGHGGGR 25 0 Q5T6F2;H0YDN2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 IPYQS(0.377)PVS(0.543)S(0.031)S(0.048)ESAPGTIMNGHGGGR;IPYQS(0.084)PVS(0.417)S(0.136)S(0.363)ESAPGTIMNGHGGGR 144.45 2.4591e-09 20161000.0 3541.6 3437.7 3590.4 3673.2 4047.7 3247.8 4233.1 3372.5 1595.34 2697.0 True False 3624.1123892460187 3035.2124858566267 3102.8434006554876 3031.7445745036375 3681.586249679478 3215.130080766459 3913.7938589116384 3283.0503445761146 2707.1754609765153 3043.186221004664 1.1908940584153835 0.9973798070282387 1.0196035258174667 0.9962402410926897 1.2097801390754377 1.0565012612685365 1.2860842467995783 1.0788200609991798 0.8895858696687909 1.0 11.571366903726473 -8.165466139847151 6.200647148222462 0.946505955711121 1.1034198686710592 0.3121062653533734 0.09519891605357411 0.27926527784679384 14.59565045348565 0.06779167904982852 0.02494302953018815 6.831779804775655e-09 8.165466139847151 0.15691391295993828 IQAAAST(ph)PTNATAASDANTGDR ddPTM_A459_Selumetinib_30min_R2 2 IQAAASTPTNATAASDANTGDR 22 0 P49841;P49841-2 P49841 GSK3B Glycogen synthase kinase-3 beta 1 IQAAAS(0.026)T(0.97)PT(0.003)NAT(0.002)AASDANTGDR;IQAAAS(0.043)T(0.851)PT(0.105)NAT(0.001)AASDANTGDR 179.19 9.0656e-16 4320600.0 26647.0 21877.3 27040.7 27297.0 27133.0 23213.5 21289.5 25779.0 19111.7 25619.8 True False 25166.066416392714 23555.21856339322 25300.930801688068 23579.101510048502 23724.30996790237 26410.948913827775 22279.503934343942 25854.012622056798 22934.574025514852 24880.08980576545 1.0114941952725989 0.9467497403459847 1.016914769971011 0.9477096623897447 0.9535459941308069 1.061529484821537 0.8954752216843336 1.0391446664338673 0.9218043103767349 1.0 14.602704072497813 -5.767632962648793 24.92849402460728 0.9753051494221893 0.9872225836213676 0.021956459233858028 0.0506940570512675 998.3383335078396 4018223.8804719895 0.013272300861558168 0.020278850031110553 1.707524867946886e-06 5.767632962648793 0.011917434199178345 IQALQQQADEAEDR ddPTM_A459_Selumetinib_30min_R2 1 IQALQQQADEAEDR 14 0 P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A590UJB9;A0A590UK79 P67936 TPM4 Tropomyosin alpha-4 chain 0 227.48 1.8855e-50 0.0 11168.0 6748.6 8942.7 8981.8 9365.2 5924.1 8468.1 7103.3 6478.9 7215.4 False True 10547.3272690462 7266.195919830844 8367.33641807557 7758.463345530779 8188.659850049727 6740.091001374511 8861.883429221823 7123.9694269853835 7774.861035591192 7007.072654139376 1.5052401751272615 1.0369802453151948 1.1941272527169573 1.1072331811698177 1.1686277928361906 0.9618982610937896 1.2647055149323636 1.0166826831425748 1.109573343869676 1.0 12.774596139823691 -4.755694667969048 24.997514910588542 1.102898726175581 1.505240821965424 0.6498539783268067 0.0900752473341958 109.68259166782802 477223.79492762877 0.020626014294066818 0.17860073097103188 1.7551140063188944e-05 4.755694667969048 0.40234209578984315 IQDPTEDAEAEDT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 IQDPTEDAEAEDTPR 15 0 O96028-3;O96028;H0Y9L4;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 IQDPT(0.001)EDAEAEDT(0.999)PR;IQDPTEDAEAEDT(1)PR 173.09 8.1055e-05 53630000.0 3946.8999999999996 5791.0 5376.4 4903.0 4911.1 4245.3 4935.2 4543.9 2670.1 3815.05 True False 4038.855090669505 5112.987027837136 4646.3144104512485 4046.783090708738 4466.891872125126 4202.596136423996 4562.933890647683 4423.381011332665 4530.964683611892 4304.748829233905 0.9382324616110715 1.1877550190883193 1.079346227797948 0.9400741486301594 1.0376660867621577 0.976269766980089 1.0599768004257117 1.027558444593357 1.0525503027822987 1.0 12.071713347280742 -5.59043948015333 24.999425734208447 1.0155066331547387 1.0806367254414615 0.11976209073511634 0.06573390850827157 87.18150995175782 32258.400103914984 0.01699873890435524 0.029442687518520243 2.567796010933469e-06 5.59043948015333 0.06513009228672284 IQDPTEDAEAEDT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 IQDPTEDAEAEDTPR 15 0 O96028-3;O96028;H0Y9L4;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 IQDPTEDAEAEDT(1)PR;IQDPTEDAEAEDT(1)PR;IQDPTEDAEAEDT(1)PR 210.57 2.7028e-06 80001000.0 130770.0 143130.0 153856.0 168583.0 178645.0 130866.0 135997.0 127060.0 106379.0 152086.0 True False 123502.32691378676 154107.61076451236 143957.07246574658 145621.70457810428 156202.01799343672 148891.60361673098 142321.12997294308 127429.72356408465 127657.77247760513 147694.88201311632 0.8361990966133742 1.0434187607856753 0.9746923556427785 0.9859631057843431 1.057599395892167 1.0081026612926802 0.96361585474779 0.8627903812724398 0.86433443554441 1.0 17.172260308513607 -10.409758295004476 4.647474638004659 1.0000002339160479 0.9613626665181365 0.02651255886646897 0.07332405413545065 107572099.38068944 51.67902620567521 298.4253819764407 0.018673453892170185 3.892617269012249e-11 10.409758295004476 -0.038637567397911354 IQEQES(ph)SGEEDSDLSPEER ddPTM_A459_Selumetinib_30min_R1 2 IQEQESSGEEDSDLSPEER 19 0 E7EMN6;Q6NXS1;P41236 E7EMN6 PPP1R2;PPP1R2P3 Protein phosphatase inhibitor 2-like protein 3;Protein phosphatase inhibitor 2 1 IQEQES(0.5)S(0.5)GEEDSDLSPEER;IQEQES(0.764)S(0.236)GEEDSDLSPEER 239.13 9.751e-30 8535300.0 6669.17 7348.610000000001 7613.549999999999 7437.87 7271.139999999999 6087.5599999999995 6770.29 6233.969999999999 3858.7999999999997 5143.2 True False 6824.548685054174 6488.231324923896 6579.671728236571 6138.985630611835 6613.466670824034 6026.324673462241 6259.6015745082495 6068.624864811613 6548.101764398929 5803.379819010447 1.1759610602598556 1.118009078721686 1.1337654838105171 1.057829372205146 1.1395888046410372 1.0384163817300878 1.0786131133453185 1.045705270734183 1.1283255565918597 1.0 12.50267763800121 -1.5228787452803376 0.1397353128271581 1.006946261840962 1.5250087948493116 0.500725939381649 0.037308085669676416 63.79678381874038 0.5962874318333531 0.15414432114912507 6.596019747027364 0.029999999999999995 1.5228787452803376 0.5180625330083497 IQEQESS(ph)GEEDSDLSPEER ddPTM_A459_Selumetinib_30min_R2 2 IQEQESSGEEDSDLSPEER 19 0 E7EMN6;Q6NXS1;P41236 E7EMN6 PPP1R2;PPP1R2P3 Protein phosphatase inhibitor 2-like protein 3;Protein phosphatase inhibitor 2 1 IQEQES(0.093)S(0.907)GEEDSDLSPEER;IQEQES(0.227)S(0.772)GEEDS(0.002)DLSPEER 299.6 3.376799999999998e-100 37102000.0 56113.0 40617.0 59648.0 52333.0 58968.0 32630.0 31578.0 42704.0 37143.0 43382.0 True False 52994.46409813658 43732.193295760524 55810.312619831966 45205.15512053954 51559.91265939138 37124.48631435159 33046.43957061993 42828.261569972245 44572.63786213146 42129.448940027505 1.2578959713803934 1.0380433258933572 1.3247339811939998 1.0730060861914048 1.2238449340457411 0.8812003776075822 0.7844023694129609 1.0165872720276858 1.0579924253360613 1.0 15.362541424889708 -6.759844027731236 24.99508053504795 0.9388460462214976 1.1771309240036902 0.552343968787413 0.10575182556830702 33.008376296981574 517159.3602332755 0.03589613496783728 0.03410279219893623 1.738425053617954e-07 6.759844027731236 0.23828487778219265 IQFTSLYHKEEAPAS(ph)PLRPLY(ph)PQISPLK ddPTM_A459_Selumetinib_30min_R1 1 IQFTSLYHKEEAPASPLRPLYPQISPLK 28 2 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 2 IQFT(0.006)S(0.006)LY(0.007)HKEEAPAS(0.924)PLRPLY(0.793)PQIS(0.265)PLK 57.735 0.0099955 2298700.0 673.23 487.79 705.72 687.11 1242.0 749.66 696.58 484.66 333.5 468.41 True False 688.9149491224581 430.6793200325811 609.8871002424773 567.1191371521279 1129.6613192929103 742.1191010368193 644.036409780225 471.80524240244915 565.925142123728 528.5349861997754 1.3034424723249303 0.8148548937681735 1.1539200169654473 1.073002075472386 2.137344449825922 1.4041059161905953 1.2185312734184683 0.8926660575391246 1.0707430102078803 1.0 9.045855163267849 -7.6110729468612215 5.087407501718564 0.9892690513564845 1.3110065468824408 0.17034726882444706 0.32185429751996614 0.4274347042308512 18.624680313164113 0.17233829418018795 0.09705869446982969 2.4486519161636913e-08 7.6110729468612215 0.3217374955259563 IQFTSLYHKEEAPAS(ph)PLRPLYPQIS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 IQFTSLYHKEEAPASPLRPLYPQISPLK 28 2 P85037;P85037-2;U3KQ26 P85037;U3KQ26 FOXK1 Forkhead box protein K1 2 IQFT(0.008)S(0.008)LY(0.031)HKEEAPAS(0.95)PLRPLY(0.282)PQIS(0.721)PLK 47.105 0.020757 2045700.0 821.04 672.69 1209.0 1151.7 1458.5 936.2 963.25 987.64 307.04 423.56 True False 840.1686345342641 593.9311420749033 1044.8244405616326 950.57721508653 1326.5789325190888 926.7826780015881 890.5912769829762 961.4445788931511 521.0244546856655 477.9280518237804 1.7579395712977475 1.2427208233717468 2.1861542476416007 1.9889546375424367 2.7756875275616157 1.9391677773777287 1.8634421511448573 2.011693130847341 1.0901734114526835 1.0 8.900649638337006 -8.278435593024529 6.074000046835477 1.0282668768351686 1.977454755533408 0.5156322752861278 0.3588846300630231 0.1475253142116097 22.035454943626675 0.3353589123835838 0.09738079485523408 5.26701320246602e-09 8.278435593024529 0.9491878786982395 IQFVEGPVEPGKPT(ph)SPEHVVYEGETVTR ddPTM_A459_Selumetinib_30min_R2 2 IQFVEGPVEPGKPTSPEHVVYEGETVTR 28 1 Q9H7C4-2;Q9H7C4;C9JTN4;C9JSS1 Q9H7C4-2 SYNC Syncoilin 1 IQFVEGPVEPGKPT(0.46)S(0.46)PEHVVY(0.042)EGET(0.019)VT(0.019)R;IQFVEGPVEPGKPT(0.497)S(0.497)PEHVVY(0.004)EGET(0.001)VT(0.001)R 65.801 0.00052468 8332700.0 20418.8 17536.2 21877.0 20628.9 21399.7 17430.7 17802.2 21668.2 14631.4 20153.3 True False 19284.004838932713 18881.170152229748 20469.457637876607 17819.208233162608 18711.278370254677 19831.62070485958 18630.037574390095 21731.250874636375 17558.08883547345 19571.421864438176 0.9853144535181827 0.9647316522535015 1.0458850552432364 0.9104708056771599 0.9560510472799932 1.0132948358184537 0.9519000562877548 1.1103562646167608 0.8971289340697821 1.0 14.25646095116352 -6.764262494194189 24.998044604383434 0.9987685361909665 0.9726914756587836 0.031217128563869156 0.059093087581601776 279.9242519356961 2478651.778331051 0.01949052074111084 0.017947615732896004 1.7208281658661903e-07 6.764262494194189 -0.02607706053218295 IQIISTDSAVAS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 4 IQIISTDSAVASPQR 15 0 P49116;P49116-2;C9JKS0;C9JMI6;C9J2Y1 P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 1 IQIISTDSAVAS(1)PQR;IQIISTDSAVAS(1)PQR;IQIISTDSAVAS(1)PQR;IQIISTDSAVAS(1)PQR 217.65 3.1211e-09 39217000.0 121530.0 128469.0 145882.0 138709.0 145256.0 105263.0 100909.0 124456.0 100576.0 118468.0 True False 114775.84912313601 138322.15920705732 136496.1109443119 119816.59491362856 127007.64267488384 119762.02276762477 105601.46844739003 124818.14635520021 120694.0103282378 115047.52102317069 0.9976386114397027 1.2023045605580593 1.1864324387904146 1.0414530782414457 1.103958099621324 1.040978733852984 0.9178943406014093 1.0849268653955761 1.04907962600889 1.0 16.81187037198309 -6.482066028742989 1.5183452607567878 1.017763280679222 1.125894999309908 0.27634223802436975 0.06975404987140366 0.5065508470405878 2.374107212275662 0.028302513437037314 0.032292369259464 3.295596031810972e-07 6.482066028742989 0.10813171863068605 IQIVTAVDASGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 IQIVTAVDASGSPK 14 0 P49116;P49116-2;C9JKS0;C9JMI6 P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 1 IQIVTAVDAS(0.011)GS(0.989)PK 136.39 0.00059551 15061000.0 1191.5 1584.1 1941.6 2179.5 1388.9 1481.7 1128.2 1105.1 1091.3 1297.0 True False 1219.2596317445873 1398.6328355718897 1677.9413844453816 1798.891239282011 1263.2742402302113 1466.7954432759602 1043.0989656809697 1075.7891581292997 1851.8563946015734 1463.482583849851 0.8331220645873294 0.9556880628484373 1.1465400428827608 1.2291852729465567 0.8631973172560963 1.0022636821665445 0.7127511985397078 0.7350884595423874 1.265376448642158 1.0 10.515189861742568 IQIVTAVDASGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 IQIVTAVDASGSPK 14 0 P49116;P49116-2;C9JKS0;C9JMI6 P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 1 IQIVTAVDAS(0.03)GS(0.97)PK;IQIVTAVDAS(0.168)GS(0.832)PK 142.55 0.00054517 10902800.0 91844.0 89121.0 92391.0 73271.0 70208.0 48956.0 72792.0 76404.0 55992.0 66016.0 True False 86739.67816066256 95956.29413081885 86446.66364771508 63291.363400474926 61387.84337251641 55699.24462167934 76176.97223461162 76626.32299063682 67191.96454719492 64109.9465498331 1.352983161407555 1.4967458139468477 1.3484126613725922 0.9872315733609 0.9575400803804948 0.8688081587836598 1.1882239236527632 1.195232988239581 1.0480739442664508 1.0 15.968260585455619 -5.678939125152834 4.823592911259233 1.0395238777132663 1.422595057341354 0.7405355641588265 0.09922775123757333 0.11236790351214167 4.612207532911323 0.030404383068640913 0.053424299437199806 2.094406007152482e-06 5.678939125152834 0.3830711796280877 IQNS(ph)DDEER ddPTM_A459_Selumetinib_30min_R2 2 IQNSDDEER 9 0 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 IQNS(1)DDEER;IQNS(1)DDEER 121.21 0.006335 6304200.0 14282.4 8424.3 11217.199999999999 16024.1 18270.6 16531.9 26612.0 37163.8 25382.6 14916.1 True False 13488.641384977203 9070.416721606112 10495.49756436392 13841.589936885672 15975.28388676361 18809.019163353627 27849.510730677594 37271.940505201725 30459.829249100465 14485.433436317939 0.9311865912937355 0.6261750303490903 0.7245552996743312 0.9555523483461654 1.102851630708565 1.2984781743703697 1.9225873256131352 2.57306353096438 2.102790322637599 1.0 13.822315233441225 -6.997122834417656 1.7322883987985667 2.0442705022748364 0.8149815299492348 0.6058195394956358 0.3878322997959728 0.21717783599266421 1.3153356182872158 0.1783037884048094 0.1356745273943933 1.0066469118942236e-07 6.997122834417656 -1.2292889723256017 IQNTGDY(ph)YDLYGGEK ddPTM_A459_Selumetinib_30min_R1 2 IQNTGDYYDLYGGEK 15 0 Q06124;Q06124-1;A0A1W2PPU4;Q06124-3 Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 1 IQNT(0.002)GDY(0.778)Y(0.211)DLY(0.009)GGEK;IQNT(0.012)GDY(0.762)Y(0.226)DLY(0.001)GGEK 140.33 0.0054525 14653700.0 2909.0 3445.7 3207.6 3075.0 3497.8 2924.5 3157.0 3324.7 1777.1599999999999 2746.9 True False 2976.7740400713446 3042.2758421375297 2772.0255380856006 2538.008974898915 3181.4246075867454 2895.082185233546 2918.8649482847195 3236.5181558523955 3015.7107213691284 3099.4913720718228 0.9604072677516605 0.9815403487004876 0.8943485253945614 0.8188469236494145 1.02643441315991 0.9340507321039447 0.9417238501082307 1.0442094419152967 0.972969548662853 1.0 11.597815772679539 -7.405624124441455 1.2598492370812828 1.005753499158816 0.9292343901866985 0.21719742749860027 0.055192333397917376 0.7421572161893353 2.2492700118817646 0.040317493870462344 0.020521114188550835 3.9298491098205615e-08 7.405624124441455 -0.07651910897211744 IQNWHEEHR ddPTM_A459_Selumetinib_30min_R1 2 IQNWHEEHR 9 0 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 A0A2R8Y5S7 RDX Radixin 0 ; 85.86200000000002 0.01952 7380000.0 1361.69 1510.9 1421.9499999999998 1581.96 1471.04 1406.69 1392.28 1409.88 784.0 1246.45 False True 1393.4147276124947 1334.0031256016468 1228.8570002122533 1305.7003830670194 1337.9846917332059 1392.539975772328 1287.2591986689415 1372.4854024643355 1330.3907389055548 1406.4439989511545 0.9907360183922174 0.9484935956187875 0.873733331102173 0.9283699770774635 0.9513245409920326 0.9901140584415765 0.9152580548026837 0.9758549956399661 0.9459251416321476 1.0 10.457836393984513 -6.4184914207211365 4.817804791534454 0.9617048781241995 0.9321610482099996 0.13571491953952441 0.03467291850656872 0.49311693743314333 18.052611163067407 0.011272914930767326 0.012735637575162679 3.815123307978219e-07 6.4184914207211365 -0.029543829914199904 IQNWHEEHR ddPTM_A459_Selumetinib_30min_R2 3 IQNWHEEHR 9 0 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 A0A2R8Y5S7 RDX Radixin 0 ;; 101.46 0.0095906 36642400.0 14502.699999999999 12668.2 14939.2 14154.6 13105.399999999998 10359.7 13399.3 10070.7 9421.400000000001 11630.599999999999 False True 13696.697992907968 13639.810205316835 13978.028136571116 12226.71906195306 11458.982488237483 11786.654639006685 14022.39400020925 10100.004069705861 11305.943255910543 11294.794358072106 1.212655809277243 1.207619171531778 1.237563756668254 1.0825092227743776 1.014536619699325 1.043547519799071 1.2414917488238992 0.8942176147268801 1.0009870828529488 1.0 13.46337038367661 -5.602334291573871 0.39960307357920943 0.9872803678747092 1.328697746181731 0.46965016628754996 0.08484762252668586 2.854542924637936 0.5808126401831188 0.08118390709524248 0.4398525453611912 2.4984214993996105e-06 5.602334291573871 0.3414173783070219 IQPAGNTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 IQPAGNTSPR 10 0 H0Y5S9;H0Y682;P49674 H0Y5S9 CSNK1E Casein kinase I isoform epsilon 1 IQPAGNT(0.009)S(0.991)PR;IQPAGNT(0.025)S(0.975)PR 125.68 0.0035845 128300000.0 11819.4 14383.8 15659.4 16299.4 14997.3 11888.4 12757.8 13261.900000000001 6516.200000000001 10182.2 True False 12094.769023451094 12699.738009152801 13532.939490927069 13453.015767631668 13640.796862988367 11768.81348980355 11795.468874636286 12910.151331277686 11057.515475582115 11489.184553026947 1.0527090906782064 1.1053646105638473 1.1778851169521576 1.170928685629593 1.1872728477840104 1.0243384493900336 1.026658490878593 1.123678645050259 0.9624282232170164 1.0 13.487988785622926 -6.773597619497607 24.993952420303824 1.0351030119265698 1.1409255263895457 0.5230451841640412 0.05292228128081475 201.26916826896314 413750.9403828858 0.019144573402342678 0.01700524035148344 1.6842338068638738e-07 6.773597619497607 0.10582251446297586 IQPEDMFVCDINEKDISGPS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 IQPEDMFVCDINEKDISGPSPSK 23 1 S4R3D6;Q96GX9-3;Q96GX9 S4R3D6 APIP Methylthioribulose-1-phosphate dehydratase 1 IQPEDMFVCDINEKDIS(0.005)GPS(0.73)PS(0.265)K;IQPEDMFVCDINEKDIS(0.031)GPS(0.859)PS(0.11)K 75.695 0.00049167 49051000.0 1788.46 1588.98 4507.3 5020.4 2385.1 1860.17 1796.19 1641.5 1296.6 1205.74 True False 1830.1276382626322 1402.9414829032387 3895.2334168266702 4143.681384579674 2169.368126123606 1841.4583786992257 1660.701942179135 1597.9620876565439 2200.235500082835 1360.508473902174 1.3451791542418763 1.0311890810053974 2.8630717790786453 3.0456858329554377 1.5945274636191589 1.3535074672615628 1.220647995977529 1.174532991384693 1.6172155795341565 1.0 10.409930227077368 -6.513090011467802 23.136524476176593 1.3022734068875215 2.0868657221660807 0.2931714893096473 0.5833135536328203 258.1361880701626 610130.7799701721 0.207651506174718 0.2199084258233103 3.0683859716789644e-07 6.513090011467802 0.7845923152785592 IQPEEKPVEVS(ph)PAVTK ddPTM_A459_Selumetinib_30min_R1 1 IQPEEKPVEVSPAVTK 16 1 Q8N0X7 Q8N0X7 SPG20 Spartin 1 IQPEEKPVEVS(0.999)PAVT(0.001)K 65.808 0.03011 8700800.0 1489.2 1748.1 1607.6 2115.8 1595.9 1481.8 1500.1 1531.7 913.17 1461.9 True False 1523.895462521226 1543.4316393303588 1389.2967499147076 1746.3152484849184 1451.5511267790287 1466.8944373667516 1386.9462492625619 1491.0743403372078 1549.5827947020225 1649.5491051118706 0.9238254610297746 0.9356688046129339 0.8422281856353024 1.05866217809047 0.8799684242686343 0.889269942204763 0.8408032503939922 0.9039284345742983 0.9393977965857109 1.0 10.687856010516978 IQPEEKPVEVS(ph)PAVTK ddPTM_A459_Selumetinib_30min_R2 1 IQPEEKPVEVSPAVTK 16 1 Q8N0X7 Q8N0X7 SPG20 Spartin 1 IQPEEKPVEVS(0.996)PAVT(0.004)K 67.866 0.027134 8756000.0 40906.0 44530.0 42975.0 42480.0 38951.0 30720.0 40899.0 44439.0 33151.0 37297.0 True False 38632.60827969232 47945.307813482454 40210.03528764214 36694.15071791262 34057.62715364186 34951.401151605285 42800.88453983103 44568.31013272751 39782.12631633203 36220.138700756215 1.06660575208912 1.3237196082985025 1.110156855550711 1.013086974102242 0.9402953267247094 0.9649714883857018 1.1816874831276507 1.2304842480295912 1.0983427381381465 1.0 15.14450445047889 -5.509497286724906 23.591124229815616 1.0664341073752641 1.2006065999499955 0.2060309898459336 0.10382295137827327 474.0271016633375 835691.7984732651 0.029975990904953714 0.058238220335124435 3.0938746445178625e-06 5.509497286724906 0.1341724925747314 IQPLEPDSPT(ph)GLSENPTPATEK ddPTM_A459_Selumetinib_30min_R1 1 IQPLEPDSPTGLSENPTPATEK 22 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 IQPLEPDS(0.124)PT(0.475)GLS(0.38)ENPT(0.021)PATEK 64.589 0.010042 6948700.0 1846.0 2264.7 2643.0 2550.4 2348.0 2061.4 1803.8 2044.2 1400.7 2173.4 True False 1889.0082083092811 1999.547871169534 2284.0951169597984 2105.020516937299 2135.623814573069 2040.6641876014453 1667.7379137522887 1989.9811755025933 2376.885596919658 2452.3770607087636 0.7702764140859062 0.815350911246757 0.9313800693844649 0.8583592428192609 0.8708382771921095 0.8321168144557963 0.680049548852938 0.8114499223571546 0.9692170241686702 1.0 11.259965099658524 -8.308679924637756 5.074156994768695 0.9920919617519467 0.8231520056476326 0.5231091031343625 0.06250833176812429 0.18773123879742146 11.057479979128164 0.06380473987381181 0.017291599197856125 4.9126980898531e-09 8.308679924637756 -0.16893995610431412 IQPQPPDEDGDHS(ph)DKEDEQPQVVVLK ddPTM_A459_Selumetinib_30min_R1 4 IQPQPPDEDGDHSDKEDEQPQVVVLK 26 1 Q96AT1 Q96AT1 KIAA1143 Uncharacterized protein KIAA1143 1 IQPQPPDEDGDHS(1)DKEDEQPQVVVLK;IQPQPPDEDGDHS(1)DKEDEQPQVVVLK;IQPQPPDEDGDHS(1)DKEDEQPQVVVLK;IQPQPPDEDGDHS(1)DKEDEQPQVVVLK 79.762 6.3643e-05 88916000.0 20496.96 25728.1 26996.5 27651.6 18002.5 21920.32 20628.0 20304.510000000002 15226.24 21798.41 True False 20974.499287858624 22715.842091330815 23330.523581159734 22822.767144817833 16374.17705359952 21699.82148285813 19072.01335230193 19765.968436456376 25837.817199430272 24596.448257994154 0.8527450413919679 0.9235415557995403 0.9485322163770951 0.9278887303332565 0.6657130688890298 0.8822339410652681 0.7753970472587759 0.8036106770022046 1.0504694388561835 1.0 14.586162384117188 -8.265375624774709 24.983948896149275 1.0252347430994462 0.8487431119179428 0.43694691482068293 0.08071215537095353 351.47403363629184 2230810.972144362 0.07282011529685951 0.021537697557064524 5.427806730659711e-09 8.265375624774709 -0.17649163118150335 IQPQPPDEDGDHS(ph)DKEDEQPQVVVLK ddPTM_A459_Selumetinib_30min_R2 4 IQPQPPDEDGDHSDKEDEQPQVVVLK 26 1 Q96AT1 Q96AT1 KIAA1143 Uncharacterized protein KIAA1143 1 IQPQPPDEDGDHS(1)DKEDEQPQVVVLK;IQPQPPDEDGDHS(1)DKEDEQPQVVVLK;IQPQPPDEDGDHS(1)DKEDEQPQVVVLK;IQPQPPDEDGDHS(1)DKEDEQPQVVVLK 68.569 0.00048054 105414000.0 241980.0 241099.0 228323.0 215799.0 211593.0 176374.0 202394.0 197198.0 143671.0 213539.0 True False 228531.72032268957 259590.51804452704 213632.94675928628 186406.80392596102 185010.7956745793 200667.9175362379 211805.72203610252 197771.81353211388 172409.21450314444 207373.57422904734 1.1020291335205166 1.2518013397300336 1.030184041305694 0.8988937217240216 0.8921618695265 0.967663880425753 1.0213727704869464 0.953698243700385 0.831394333362436 1.0 17.661872536583573 -5.478247473259178 4.484327863305465 0.9396624446167869 1.1742493261878997 0.7000025574417359 0.06206241734728115 0.1099167087073172 4.850221627359063 0.016810716119394192 0.03505565979970703 3.324700484847875e-06 5.478247473259178 0.23458688157111274 IQPS(ph)SPPPNHPNNHLFR ddPTM_A459_Selumetinib_30min_R1 1 IQPSSPPPNHPNNHLFR 17 0 H0Y4E8;Q9Y2K2-7;Q9Y2K2;Q9Y2K2-8 H0Y4E8 SIK3 Serine/threonine-protein kinase SIK3 1 IQPS(0.771)S(0.229)PPPNHPNNHLFR 85.163 0.0078563 15847000.0 946.35 1266.9 1235.4 1432.4 1181.3 893.86 1168.7 952.39 436.05 1046.3 True False 968.3981137234503 1118.5707590341694 1067.6394655664528 1182.258229478116 1074.451623575455 884.8685799599436 1080.5440180742316 927.1295234012885 739.9450021680707 1180.6027968250573 0.8202573433907833 0.9474573176027468 0.9043172423761897 1.0014021927251997 0.9100873100291902 0.749505745996521 0.9152477200461414 0.7853018186087453 0.6267518628263222 1.0 10.205307949280737 -6.661729110273853 7.332622741584787 0.8084751506723019 0.9236297757337462 0.1975795929430152 0.10141607325545146 0.34508701392484903 22.22917759561028 0.032796936389406894 0.03273047031202213 2.1790685352358782e-07 6.661729110273853 0.11515462506144425 IQPS(ph)SPPPNHPNNHLFR ddPTM_A459_Selumetinib_30min_R2 2 IQPSSPPPNHPNNHLFR 17 0 H0Y4E8;Q9Y2K2-7;Q9Y2K2;Q9Y2K2-8 H0Y4E8 SIK3 Serine/threonine-protein kinase SIK3 1 IQPS(0.5)S(0.5)PPPNHPNNHLFR;IQPS(0.5)S(0.5)PPPNHPNNHLFR 77.899 0.012822 22342000.0 53068.0 38607.0 58109.0 57743.0 62625.0 40136.0 43562.0 43562.3 44101.0 43999.0 True False 50118.69300803579 41568.0327589292 54370.33020429549 49878.30378776902 54757.48762539657 45664.369681667646 45587.71931646545 43689.05908087302 52922.43228489515 42728.63454686901 1.17295330261632 0.972837845153541 1.2724565336778246 1.167327351241649 1.281517376019426 1.0687065048048383 1.0669126172627938 1.0224773046035562 1.2385706411199395 1.0 15.382915593972259 IQPSFQS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 IQPSFQSPVK 10 0 H0Y3G1;Q5TGL8 H0Y3G1 PXDC1 PX domain-containing protein 1 1 IQPS(0.054)FQS(0.946)PVK;IQPS(0.043)FQS(0.957)PVK 114.76 0.005150399999999999 2691200.0 40166.0 41848.0 43154.0 37590.0 43832.0 28976.0 34619.0 38856.0 28593.0 40518.0 True False 37933.734517237615 45057.60703747166 40377.51862252263 32470.177153633136 38325.432296948245 32967.18098206104 36228.852096247116 38969.06452704294 34312.39895517123 39348.14006159317 0.9640540685749941 1.145101317799043 1.026160793351811 0.8252023374626173 0.9740087393446287 0.8378332731980783 0.9207259107936662 0.9903661130117751 0.8720208604894844 1.0 15.2640078224656 -5.5842455689233095 8.110083162650943 0.9163004160117124 1.0622718815530394 0.41621326559159466 0.06984111677178517 0.2034348085986943 23.75179585616053 0.01778403992649212 0.030932067139183204 2.6046803343747543e-06 5.5842455689233095 0.145971465541327 IQPSS(ph)PPPNHPNNHLFR ddPTM_A459_Selumetinib_30min_R1 1 IQPSSPPPNHPNNHLFR 17 0 H0Y4E8;Q9Y2K2-7;Q9Y2K2;Q9Y2K2-8 H0Y4E8 SIK3 Serine/threonine-protein kinase SIK3 1 IQPS(0.152)S(0.848)PPPNHPNNHLFR 85.976 0.017477 0.0 575.11 749.56 1032.4 860.76 1006.6 605.79 861.41 816.67 410.19 663.68 True False 588.5089440307424 661.8011667390099 892.2057505672702 710.4444244663376 915.5532077296639 599.6963026133114 796.4331501748301 795.0092586819788 696.062470907742 748.8697927906467 0.785862842507877 0.8837332913013123 1.191403043835545 0.9486888525959664 1.22257996856553 0.8008018328240434 1.0635135210981599 1.061612133825554 0.9294839738613045 1.0 9.54857108652937 -5.025257720661939 11.45790350870736 1.0275769004100945 0.8101604539108828 0.31827326518750554 0.11659269971436714 0.8811042439178519 402.4087647932769 0.027894990283943825 0.07765458112105053 9.43500814329865e-06 5.025257720661939 -0.21741644649921177 IQPSS(ph)PPPNHPNNHLFR ddPTM_A459_Selumetinib_30min_R2 1 IQPSSPPPNHPNNHLFR 17 0 H0Y4E8;Q9Y2K2-7;Q9Y2K2;Q9Y2K2-8 H0Y4E8 SIK3 Serine/threonine-protein kinase SIK3 1 IQPS(0.153)S(0.847)PPPNHPNNHLFR 67.102 0.020657 8899500.0 50587.0 45299.0 60808.0 67460.0 74026.0 47008.0 63992.0 55174.0 51065.0 47590.0 True False 47775.577055805894 48773.287640757735 56895.67948274446 58271.83162500908 64726.192079163404 53482.92530386272 66967.75479774245 55334.54720545257 61279.42687531277 46215.95304633052 1.0337464426604355 1.0553344554393056 1.2310831159471654 1.2608596768867406 1.4005162246524865 1.1572394763826943 1.4490181503042616 1.1973040380662678 1.325936669830901 1.0 15.496103313616988 -5.295840575509633 2.8135506312837517 1.2732706620204908 1.03219758373711 0.3207224895463209 0.11997964970247951 0.2721532067568428 4.217372525927966 0.030064505161187232 0.08702189028301953 5.060103784818803e-06 5.295840575509633 -0.24107307828338076 IQQALTSPLPMT(ph)PILEGSHR ddPTM_A459_Selumetinib_30min_R1 1 IQQALTSPLPMTPILEGSHR 20 0 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 IQQALTSPLPMT(0.997)PILEGS(0.003)HR 101.86 0.0009152 14103000.0 1096.6 1234.8 1312.2 1524.7 1554.0 1138.0 1539.2 1547.2 1021.5 1470.5 True False 1122.148646387843 1090.2290419570534 1134.0104473986553 1258.4397671636982 1413.4409743809845 1126.552753221328 1423.0969047829713 1506.1632299861133 1733.4108925918695 1659.2529988829658 0.676297494802354 0.657060160621082 0.6834463750628074 0.7584375426839058 0.851853801278367 0.6789517656317272 0.8576732455755822 0.9077357286683134 1.0446935420691286 1.0 10.696318166377933 -7.622641402419481 0.7909144715918403 1.0383432484642614 0.6964547804000318 0.8153579583399692 0.05794529311149324 0.2757465666242741 0.3223514309066116 0.05432277603089519 0.02638782995694439 2.3842873663187854e-08 7.622641402419481 -0.34188846806422957 IQQFDDGGS(ph)DEEDIWEEK ddPTM_A459_Selumetinib_30min_R1 2 IQQFDDGGSDEEDIWEEK 18 0 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6;Q5H9R7-3 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 IQQFDDGGS(1)DEEDIWEEK;IQQFDDGGS(1)DEEDIWEEK 142.79 0.00019746 16411000.0 2073.91 3202.62 2762.0299999999997 3081.6 2666.89 2555.13 2482.04 2785.47 1388.6799999999998 2348.56 True False 2122.228067873619 2827.655761542356 2386.9614967447865 2543.456408796258 2425.670270377672 2529.4277120724173 2294.817724498133 2711.5902871182893 2356.488534825722 2650.0205529116483 0.8008345692043294 1.067031634315264 0.9007332015301421 0.9597874273094579 0.9153401726309341 0.9544936205469303 0.8659622363972821 1.023233681768616 0.8892340598025118 1.0 11.371787833571405 -11.483762299006395 2.2673943876801412 1.052338894528828 0.9357804045729399 0.07199854622497259 0.07259415360579174 30833234.431490768 12739013.274494346 8486961.728483763 0.0162651187741389 3.282749176004952e-12 11.483762299006395 -0.11655848995588802 IQQFDDGGS(ph)DEEDIWEEKHIAFTPESQR ddPTM_A459_Selumetinib_30min_R1 1 IQQFDDGGSDEEDIWEEKHIAFTPESQR 28 1 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YEN2;H7BXH2;E9PKF6;Q5H9R7-4;Q5H9R7-6;Q5H9R7-3 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 IQQFDDGGS(1)DEEDIWEEKHIAFTPESQR 69.181 0.00025431 6362600.0 455.69 193.06 1026.6 1203.4 577.86 264.69 383.48 213.74 149.53 204.64 True False 466.3066903816124 170.45644544884095 887.193358710151 993.248780615725 525.5926650294695 262.0274589192911 354.5537948584806 208.07092087463272 253.74148876090266 230.9075373624005 2.019452009701017 0.7382021712929887 3.842201813090818 4.301500037466768 2.276204021025836 1.134772220570908 1.5354795209738956 0.9011006017879504 1.0988878564092308 1.0 7.851171456597781 -6.677602900876626 4.372360741399162 1.1498164866987521 2.7277426847804747 0.4049282297354856 0.9195840437498322 0.252215182939646 8.888615495517822 0.34965294103314704 0.3443354265654483 2.1008599364680873e-07 6.677602900876626 1.5779261980817225 IQQHVGEEAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IQQHVGEEASPR 12 0 Q8TER5;Q8TER5-2;Q8TER5-4;Q8TER5-3 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 IQQHVGEEAS(1)PR 108.66 0.0079662 2644600.0 11921.0 10230.0 11694.0 11013.0 11776.0 6901.9 8719.6 8930.3 7365.0 9687.3 True False 11258.478543544028 11014.608105365494 10941.620771464519 9513.010401515336 10296.59360122427 7852.574075789859 9125.078677559613 8956.285694509248 8838.20579529382 9407.602478371868 1.1967425887124095 1.1708198906882112 1.1630615554408648 1.0112045468955349 1.0944970968848011 0.8347051327735172 0.9699685651618701 0.952026376018736 0.9394748359757872 1.0 13.199611384526186 -5.972166107906478 1.151034750892842 0.9438244355051318 1.1965082386331745 0.7350264231662246 0.05793342605252383 0.24564832770507875 0.6601916520285976 0.02158668993904259 0.04428222463522858 1.0661882501228204e-06 5.972166107906478 0.2526838031280426 IQQNQS(ph)IR ddPTM_A459_Selumetinib_30min_R1 2 IQQNQSIR 8 0 E9PF63;O75116;Q14DU5 E9PF63 ROCK2 Rho-associated protein kinase 2 1 IQQNQS(1)IR;IQQNQS(1)IR 133.75 0.002981 42836000.0 4991.200000000001 5158.5 6526.9 7318.4 5228.5 5297.9 5050.1 4715.8 2995.5 3099.1 True False 5107.485248815434 4554.5404218784115 5640.582829695382 6040.3788233821815 4755.58309816665 5244.607936108323 4669.166891141165 4590.721664922771 5083.144717336211 3496.899672790342 1.4605752886069876 1.3024509846014907 1.6130239233299175 1.727352623348864 1.3599426758423256 1.499787934128348 1.3352304406878839 1.3127976477688355 1.4536146852849596 1.0 11.77186068989298 -9.68579108568086 0.3694355379869272 0.8984039640516164 1.5070180646216333 0.5595105524775543 0.1244387121041651 4.534352583775491 0.7630292594577853 0.7878395766434527 0.10532544020796127 2.061621403314668e-10 9.68579108568086 0.608614100570017 IQQNQS(ph)IR ddPTM_A459_Selumetinib_30min_R2 2 IQQNQSIR 8 0 E9PF63;O75116;Q14DU5 E9PF63 ROCK2 Rho-associated protein kinase 2 1 IQQNQS(1)IR;IQQNQS(1)IR 98.04 0.019782 70092000.0 102824.0 86329.0 91027.0 138948.0 100946.0 64726.0 62295.0 70777.0 76375.0 77189.0 True False 97109.45371708513 92950.15670851403 85170.42192270387 120023.04270133073 88264.26101130994 73641.41897587267 65191.84093520075 70982.94935223686 91652.13409579959 74960.35300889268 1.2954775400479352 1.2399909148972015 1.136206254426256 1.601153648343841 1.1774792602809514 0.9824049116622551 0.8696842840036643 0.9469399022682834 1.2226747929659127 1.0 16.19384012660978 -6.600339593209363 4.522648890692583 0.9948054240844618 1.3093000824762389 0.5312180344074706 0.13852628810386095 0.17156105458803567 6.594242843934844 0.04760241734457347 0.04783428717565926 2.5099230490784276e-07 6.600339593209363 0.31449465839177704 IQRPNTTQEGEEMETDMDVADVAMES(ph)SPGSSISMEHR ddPTM_A459_Selumetinib_30min_R1 1 IQRPNTTQEGEEMETDMDVADVAMESSPGSSISMEHR 37 1 A0A087X1S3 A0A087X1S3 HUWE1 1 IQRPNTTQEGEEMETDMDVADVAMES(0.533)S(0.434)PGS(0.018)S(0.009)IS(0.005)MEHR 72.553 4.2181e-06 7718100.0 433.23 405.54 359.35 437.53 538.82 407.62 381.78 292.23 117.97 229.5 True False 443.3234160811648 358.0591882695687 310.5522437682571 361.1235989552917 490.0838261363976 403.5197128893477 352.9820272271585 284.47911110318097 200.1864738121025 258.9585605193066 1.7119473293029557 1.382689135866098 1.199235287474128 1.3945227307068235 1.8925183440686428 1.5582404848101685 1.3630830605456736 1.0985507122556455 0.7730444338687062 1.0 8.016577440904676 -7.804680169120459 2.357437025479965 0.8927322644667472 1.509948708281088 0.6547280266350429 0.1868951865227661 0.20425563553391457 2.241208841372283 0.13957896328870428 0.05780045303761262 1.5679053098043814e-08 7.804680169120459 0.6172164438143408 IQS(ph)TPVK ddPTM_A459_Selumetinib_30min_R2 2 IQSTPVK 7 0 E7END7;P62820-2;P62820;P62820-3 E7END7 RAB1A Ras-related protein Rab-1A 1 IQS(0.739)T(0.261)PVK;IQS(0.708)T(0.292)PVK 108.57 0.016212999999999998 101218000.0 597460.0 317300.0 421180.0 529970.0 429770.0 361170.0 715440.0 568460.0 494830.0 506830.0 True False 564255.5650218781 341635.88971969375 394081.7373461114 457787.1717507558 375778.4504074518 410917.88912517217 748709.377617466 570114.1244863803 593809.8267053961 492196.5009975142 1.1464030400019602 0.6941046696336006 0.8006593637854847 0.9300902603390669 0.7634724132452734 0.8348655227990893 1.521159488334614 1.1583059272687914 1.2064486957992313 1.0 18.908874876216068 -7.23051919339957 24.669352058722165 1.2346706995336756 0.8498686851045143 0.5316193694038982 0.16508052029200676 406.777743226684 324543.8147307504 0.06021932577011024 0.04664029989538124 5.881401210478853e-08 7.23051919339957 -0.3848020144291613 IQSQVSQHVGS(ph)MFY(ph)K ddPTM_A459_Selumetinib_30min_R2 1 IQSQVSQHVGSMFYK 15 0 Q7Z3H4 Q7Z3H4 SAMD7 Sterile alpha motif domain-containing protein 7 2 IQS(0.002)QVS(0.193)QHVGS(0.815)MFY(0.99)K 89.507 0.042903 3596300.0 6502.3 7061.2 16531.0 21810.0 27856.0 18451.0 8206.1 14471.0 18582.0 18892.0 True False 6140.928196769256 7602.771334663422 15467.41345759191 18839.44037565145 24356.48024420035 20992.457768498367 8587.699910078665 14513.10821419699 22298.919224460235 18346.53887268914 0.33471862128233404 0.4143981263943463 0.8430698326765531 1.0268661847546652 1.3275790280235187 1.1442189676303454 0.4680828340250275 0.7910542863101749 1.215429208702392 1.0 14.163220299719699 -5.304304284435175 2.8066173398136587 0.9840177132323417 0.34182472841404643 0.5443907835971356 0.22449688814487312 0.2292747902261005 3.5232056879125815 0.06767936025302237 0.1935027947171565 4.962445104662565e-06 5.304304284435175 -0.6421929848182952 IQSSLSSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 4 IQSSLSSASPSK 12 0 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 IQSSLSS(0.003)AS(0.919)PS(0.078)K;IQSSLS(0.008)S(0.012)AS(0.768)PS(0.212)K;IQSSLS(0.001)S(0.002)AS(0.854)PS(0.143)K;IQSSLSS(0.001)AS(0.607)PS(0.392)K 188.63 0.00012455 107884700.0 11238.5 10705.800000000001 12792.900000000001 12468.100000000002 9791.3 10315.1 9564.6 9580.2 6211.799999999999 8884.5 True False 11500.335183685733 9452.359959008603 11055.69444636966 10290.780390223472 8905.678643794416 10211.339459361441 8843.134521496368 9326.101975124717 10540.970908078485 10024.912117358515 1.1471756608990582 0.942887064579996 1.102822081325412 1.026520758461772 0.8883547845146588 1.0185964066138913 0.8821159146307272 0.9302926415660261 1.051477637377628 1.0 13.291301969007023 -6.017103581016477 23.27429966295927 0.9571996476711016 1.0542403690076612 0.3042018608654887 0.06999117822756357 360.19126230864174 490144.5750268739 0.019466635102243196 0.025811364974569474 9.613829572564754e-07 6.017103581016477 0.09704072133655961 IQSSLSSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 IQSSLSSASPSK 12 0 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 IQSSLS(0.006)S(0.02)AS(0.552)PS(0.423)K;IQSSLSSAS(0.921)PS(0.079)K;IQSSLS(0.002)S(0.024)AS(0.966)PS(0.008)K 204.67 2.8476e-05 119731000.0 534865.0 467060.0 495908.0 544346.0 520213.0 452768.0 459907.0 460923.0 371956.0 510061.0 True False 505139.34453423996 502882.0001653975 464001.81918380543 470205.1357507743 454859.19217677385 515132.6821813163 481293.58678843157 462264.20962009 446357.59331898333 495334.2136323668 1.0197949801003459 1.0152377653820468 0.9367449419276012 0.949268438985232 0.9182874504896744 1.0399699193071363 0.9716542357513062 0.9332369880736301 0.9011240916426307 1.0 18.91804274841342 -5.246913872973322 21.602583148889153 0.9558312622060253 1.0175164809912385 0.2910020858863729 0.03822461861801793 173.19157344565255 257564.2122804371 0.010080574215408566 0.026279012154352247 5.663515938094708e-06 5.246913872973322 0.06168521878521316 IQVWHAEHR ddPTM_A459_Selumetinib_30min_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 96.015 0.030715 20532000.0 2598.2 2602.7 2905.4 3163.7 2536.0 2336.0 2273.7 2323.2 1408.8 2079.9 False True 2658.7330047828677 2297.9746740375977 2510.8626382198245 2611.2191850041277 2306.6192477671657 2312.5019609182978 2102.1929784336276 2261.5811891828707 2390.6307053190653 2346.8754249416374 1.1328820339277215 0.9791634654381982 1.0698746987315124 1.1126364685799477 0.982846904975592 0.9853535199789335 0.8957411868105037 0.9636562576554791 1.018644057504039 1.0 11.19652554851345 -6.391859242681571 5.694005835609429 0.9675497218723864 1.066279342914178 0.49938083437743885 0.04836517240859724 0.20460760463807254 8.630508964965399 0.015311119278845197 0.017358459443865278 4.056399843779196e-07 6.391859242681571 0.0987296210417915 IQVWHEEHR ddPTM_A459_Selumetinib_30min_R1 5 IQVWHEEHR 9 0 P26038 P26038 MSN Moesin 0 ;;;; 104.22 0.013205 51894900.0 8601.2 11644.099999999999 10478.6 10413.199999999999 9806.099999999999 9022.7 8625.099999999999 8324.85 5344.44 8273.4 False True 8801.59122497822 10280.803358804771 9055.663674829715 8594.730099973132 8919.13998640757 8931.93982995613 7974.501762892152 8104.0479350762 9069.124337546436 9335.371479740441 0.9428217445957424 1.1012741572326392 0.9700378495362776 0.920662891522352 0.9554135050505302 0.9567846174456116 0.8542243637758135 0.8681012804539754 0.9714797485272212 1.0 13.188491717002808 -5.513349633550365 6.515895591273586 0.9268221342832923 1.0257178403915794 0.2917880754062179 0.05515109229646558 0.15523199831164144 31.08902588866182 0.014590053282095861 0.02800749010126329 3.066552232762206e-06 5.513349633550365 0.09889570610828713 IQVWHEEHR ddPTM_A459_Selumetinib_30min_R2 3 IQVWHEEHR 9 0 P26038 P26038 MSN Moesin 0 ;; 100.25 0.010202 47740000.0 55906.0 47920.0 46053.0 43349.0 45824.0 43145.4 48472.0 45209.3 38344.0 45386.0 False True 52798.96832944991 51595.309912914396 43090.000118715194 37444.791418803994 40067.179448242285 49088.287215054406 50726.04404544582 45340.85157819749 46013.87142087521 44075.588253010224 1.197918630747802 1.1706096721100618 0.9776386845108592 0.8495585176051877 0.9090560338807463 1.1137295986447062 1.1508875106614462 1.0287066690505453 1.0439763425671944 1.0 15.427692204092915 -5.2255006249950755 7.2906204071852905 1.009745670268498 1.1858455483962647 0.41364459634595885 0.08339125807241757 0.2741451678366309 46.03210249866592 0.024710625747065694 0.0648499761427067 5.94975900525961e-06 5.2255006249950755 0.17609987812776673 IRAEEEDLAAVPFLAS(ph)DNEEEEDEKGNSGSLIR ddPTM_A459_Selumetinib_30min_R1 1 IRAEEEDLAAVPFLASDNEEEEDEKGNSGSLIR 33 2 A0A3B3IRP6;A0A0J9YVP0;O95714 A0A3B3IRP6 HERC2 E3 ubiquitin-protein ligase HERC2 1 IRAEEEDLAAVPFLAS(1)DNEEEEDEKGNSGSLIR 103.85 2.6495e-12 21177000.0 1642.5 2017.3 2329.7 2926.6 1803.8 1588.9 1934.7 1429.8 1065.3 1613.5 True False 1680.767054251351 1781.113578182674 2013.339536126083 2415.5242490859055 1640.646608486756 1572.9171086057722 1788.7640213640943 1391.8770593550566 1807.736293566439 1820.6084418209214 0.9231897510978775 0.9783067777062784 1.1058608154713363 1.3267675759373971 0.9011529172334427 0.863951343119438 0.9825089131054576 0.7645120320121884 0.9929297547134253 1.0 10.830204959977811 -6.41064778931537 19.764401421028786 0.9062082780312266 1.0821695461404437 0.317531699700761 0.11852917926432058 5.981903820348232 1039.950544436067 0.037907958649426345 0.04298346429649963 3.8846528170495584e-07 6.41064778931537 0.17596126810921708 IRAENGTGS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 IRAENGTGSSPR 12 1 M0R102;M0R050;Q9NQT4 M0R102 EXOSC5 Exosome complex component RRP46 1 IRAENGT(0.007)GS(0.629)S(0.364)PR 73.887 0.029077 7012000.0 28407.0 28566.0 39273.0 36349.0 35505.0 20060.0 21672.0 27308.0 23873.0 42487.0 True False 26828.25266223094 30756.920345832914 36746.21793720931 31398.203494477522 31044.54448127276 22823.082913450602 22679.7909422533 27387.461758917223 28648.267067352248 41260.28991551679 0.6502196837967835 0.7454363604523809 0.8905952433308068 0.7609787415155698 0.75240732784085 0.5531488741398181 0.5496759957017193 0.663772887078469 0.6943302416442418 1.0 15.332466337909302 -10.903742297230734 2.675616688371747 1.0066591419304927 0.6969915064540195 0.47353354024040795 0.09627321378362967 5857437.856206731 6383658.696421211 301890.29462389724 0.028823691865732613 1.2481239095067016e-11 10.903742297230734 -0.30966763547647314 IRAENGTGSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 IRAENGTGSSPR 12 1 M0R102;M0R050;Q9NQT4 M0R102 EXOSC5 Exosome complex component RRP46 1 IRAENGTGS(0.042)S(0.957)PR 79.23 0.02334 16688000.0 3302.5 3338.9 4885.7 5242.2 4474.5 3438.1 3782.1 3326.6 1829.3 2562.5 True False 3379.441824453631 2947.9800357875038 4222.248775229091 4326.748178281329 4069.782265037139 3403.515835545033 3496.813152013819 3238.3677616803284 3104.1884932141993 2891.4218358637186 1.168782009783824 1.0195606878326318 1.460267306160061 1.4964084882442805 1.4075366709062096 1.1771080211574674 1.2093749547856132 1.1199914593966436 1.0735854778128295 1.0 11.49756338677104 -7.723620156389943 1.1861956842529275 1.0275324497905631 1.3032254126234235 0.3716456776278394 0.1357874131720136 0.6119447467610392 1.5685393166352206 0.12935643269333597 0.051834960660058965 1.8896433506414948e-08 7.723620156389943 0.2756929628328604 IRAENGTGSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 IRAENGTGSSPR 12 1 M0R102;M0R050;Q9NQT4 M0R102 EXOSC5 Exosome complex component RRP46 1 IRAENGTGS(0.018)S(0.982)PR 104.24 0.047257 4347500.0 25959.0 33629.0 29948.0 40502.0 35450.0 22211.0 20322.0 24729.0 18338.0 36700.0 True False 24516.302702110504 36208.236165721995 28021.178284916998 34985.55773015294 30996.454072979002 25270.363638616724 21267.01326727906 24800.957295893666 22006.11240653063 35640.375641948485 0.6878800310189486 1.0159330678632112 0.7862200602604271 0.9816270760338219 0.869700543686088 0.7090375222890096 0.5967112546997941 0.6958668883024651 0.6174489468800543 1.0 15.12122492218707 -6.765640602041055 5.700156555047161 0.6957593099145574 0.8790385404383789 0.20743389240561416 0.1352632319980571 0.20021774165441228 21.76104049621174 0.04369715419909665 0.040734715263779656 1.7153762702968393e-07 6.765640602041055 0.18327923052382156 IRDVQCTGR ddPTM_A459_Selumetinib_30min_R2 1 IRDVQCTGR 9 1 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 104.42 0.040467 1007300.0 3052.1 4264.7 5164.1 3926.6 4411.3 3322.2 2761.5 4627.9 3310.3 4638.6 False True 2882.476500524345 4591.788776828175 4831.847428246952 3391.7903062371843 3857.113056477637 3779.802894071065 2889.9152218084387 4641.3664228099115 3972.4524975099966 4504.671565469816 0.6398860513205286 1.0193393036744673 1.0726303478560069 0.7529495229433971 0.8562473424353543 0.8390851228855014 0.6415373862016583 1.0303451329033437 0.881851748740241 1.0 12.137206207983702 IREEYPDR ddPTM_A459_Selumetinib_30min_R1 6 IREEYPDR 8 1 P68371;A6NNZ2;CON__ENSEMBL:ENSBTAP00000025008;Q9H4B7;P07437;Q5JP53;Q5ST81;Q9BVA1;Q13885;Q3ZCM7;A0A075B736;Q5SQY0 P68371;P07437;Q9BVA1;Q3ZCM7 TUBB4B;TUBB1;TUBB;TUBB2B;TUBB2A;TUBB8 Tubulin beta-4B chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta-1 chain;Tubulin beta chain;Tubulin beta-2B chain;Tubulin beta-2A chain;Tubulin beta-8 chain 0 ;;;;; 140.35 0.0066132000000000005 1299856000.0 23116.600000000002 24070.8 26780.1 29629.0 27019.4 22336.3 24854.899999999998 23171.199999999997 14413.2 19700.899999999998 False True 23655.171802926503 21252.579545788678 23143.509512559624 24454.851355212973 24575.500040662508 22111.61710173774 22980.074882205216 22556.62450533492 24458.147701522397 22229.702418016594 1.0641245374366597 0.9560442666368767 1.0411074821137691 1.1000980083023044 1.1055253722490097 0.9946879488506715 1.0337553985239345 1.014706543577181 1.1002462939719655 1.0 14.440201015142184 -5.501863018838692 24.591003141256984 1.0514207488920417 1.0072072623939499 0.1033473895658199 0.0458918833024766 1252.0877472977493 1465095.743631188 0.012077132470328314 0.024696969304487778 3.1487413044441633e-06 5.501863018838692 -0.04421348649809187 IREEYPDR ddPTM_A459_Selumetinib_30min_R2 4 IREEYPDR 8 1 P68371;A6NNZ2;CON__ENSEMBL:ENSBTAP00000025008;Q9H4B7;P07437;Q5JP53;Q5ST81;Q9BVA1;Q13885;Q3ZCM7;A0A075B736;Q5SQY0 P68371;P07437;Q9BVA1;Q3ZCM7 TUBB4B;TUBB1;TUBB;TUBB2B;TUBB2A;TUBB8 Tubulin beta-4B chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta-1 chain;Tubulin beta chain;Tubulin beta-2B chain;Tubulin beta-2A chain;Tubulin beta-8 chain 0 ;;; 127.68 0.012741 895993800.0 651836.0 537145.0 584917.0 660737.0 647454.0 517477.0 533189.0 551734.0 455886.0 577603.0 False True 615609.5646262527 578342.2943066021 547284.077029478 570743.4807650985 566115.0402078006 588754.7595614997 557983.3449939599 553339.4545955198 547075.9385191188 560926.1005971765 1.097487822318945 1.0310489985951516 0.9756794637418819 1.0175020919109847 1.0092506652928075 1.0496119879868242 0.9947537552627991 0.9864747851925953 0.9753084014751454 1.0 19.097451189433734 -4.830206025621432 3.21489884893765 1.0029099955380887 1.1059738261570111 0.6619331222586577 0.020844793875882565 0.19215942750221654 3.194132039133043 0.005634076637465468 0.04690624106287882 1.4784068780931455e-05 4.830206025621432 0.10306383061892244 IRIDS(ph)LSAQLSQLQK ddPTM_A459_Selumetinib_30min_R1 1 IRIDSLSAQLSQLQK 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 IRIDS(0.752)LS(0.248)AQLSQLQK 122.83 0.00083177 8829100.0 3993.7 3429.3 5680.8 6483.6 4823.1 3739.2 3576.4 3160.8 2385.6 2563.7 True False 4086.7454396125563 3027.795961761683 4909.378562400763 5351.360972245396 4386.851456587464 3701.5870429219603 3306.6292686238407 3076.9653162746285 4048.1889626697603 2892.775867552707 1.4127418184907459 1.0466749241527664 1.6971168134619794 1.849905148985032 1.5164850847220137 1.2795969035974808 1.1430644543579016 1.0636722156002172 1.3994132791540932 1.0 11.498238832161656 -6.906770154521811 3.4701647486271394 1.1612459576326788 1.5087775485946548 0.37422336755542707 0.21634096713041817 0.2977749489654109 7.064346693267029 0.08874382465730626 0.07677004482134503 1.2394523792344525e-07 6.906770154521811 0.34753159096197606 IRLDETDDPDDYGDR ddPTM_A459_Selumetinib_30min_R1 2 IRLDETDDPDDYGDR 15 1 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 ; 230.57 1.879e-13 21219700.0 6155.0 7136.0 4571.9 5086.1 5847.5 5166.9 6659.4 6655.700000000001 3218.6 6917.4 False True 6298.399524454834 6300.513802563603 3951.0610916490705 4197.908112921419 5318.594657459976 5114.925677169844 6157.076096486302 6479.16921523951 5461.729122756915 7805.315671181928 0.8069371938036034 0.8072080704981329 0.5062013194721664 0.5378268208191184 0.6814067337592512 0.6553131087387924 0.788831144808005 0.8300970118558183 0.6997448089027598 1.0 12.930241265108622 -7.341215550255754 3.322182432135636 0.8224479619902091 0.6590193903435628 0.3341836997242691 0.1136855667829275 0.3489419854709389 7.4686567953286485 0.05469702160607042 0.03554722752173994 4.55810630589611e-08 7.341215550255754 -0.16342857164664626 IRLDETDDPDDYGDR ddPTM_A459_Selumetinib_30min_R2 1 IRLDETDDPDDYGDR 15 1 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 145.49 0.0010195 19863000.0 87962.0 61214.0 70686.0 93898.0 89104.0 74359.0 81792.0 99691.0 68556.0 67253.0 False True 83073.42417978514 65908.91696596713 66138.1397170977 81108.9304169154 77909.95892013311 84601.27728620499 85595.49006777324 99981.0843052664 82269.11561468616 65311.23114572106 1.2719623060608587 1.0091513482407417 1.0126610470645034 1.2418833483011038 1.1929029288439232 1.29535572675769 1.3105784191511314 1.5308406004809598 1.259647294523189 1.0 15.995043483495477 -6.323337974860322 1.4712277285260835 1.3144076256976118 1.0982042579263074 0.17394601225764572 0.14407140767020934 0.5257386594382011 2.2844417689370466 0.054099503338944914 0.07076256032319955 4.7496545642285955e-07 6.323337974860322 -0.21620336777130444 IRLS(ph)PEPWTPETGLVTDAFK ddPTM_A459_Selumetinib_30min_R1 1 IRLSPEPWTPETGLVTDAFK 20 1 O95573 O95573 ACSL3 Long-chain-fatty-acid--CoA ligase 3 1 IRLS(1)PEPWTPETGLVTDAFK 132.36 7.9793e-05 6116300.0 2201.8 2211.2 2476.7 2233.8 2601.4 2049.7 2577.0 2219.4 1460.9 2487.3 True False 2253.097656042999 1952.3116760410098 2140.3777435392863 1843.7087636192507 2366.1038293144725 2029.0818789786958 2382.6148152453957 2160.534302372789 2479.040600085619 2806.569183353689 0.8027942690337235 0.6956221452229122 0.7626313850498628 0.6569261768263716 0.8430591497078701 0.7229758991916456 0.8489421281246692 0.7698133062913043 0.8832993017914165 1.0 11.454591907564676 -8.685366007311295 0.48835809081024 1.011162578828919 0.7341601708807713 0.6602314295078404 0.05553809697328168 0.7315981439415623 0.4002422790550206 0.0680520003912294 0.029619382590177046 2.063640263139373e-09 8.685366007311295 -0.27700240794814757 IRPLS(ph)DGNSPWSTILIK ddPTM_A459_Selumetinib_30min_R1 2 IRPLSDGNSPWSTILIK 17 1 Q5TCX8;Q5TCX8-3 Q5TCX8 MLK4 Mitogen-activated protein kinase kinase kinase MLK4 1 IRPLS(0.999)DGNS(0.001)PWSTILIK;IRPLS(0.998)DGNS(0.002)PWSTILIK 121.91 0.00077507 65945000.0 10708.8 12135.7 13664.7 13463.7 13331.9 10933.2 11660.9 11498.9 6624.6 9637.7 True False 10958.294204302516 10714.846602266129 11809.108794824264 11112.51753995008 12126.031998938119 10823.221934551339 10781.308924755545 11193.911818308758 11241.462358359362 10874.792674147806 1.0076784480087804 0.9852920348300607 1.0859157639756727 1.0218601745270426 1.1150586831659635 0.9952577726176735 0.9914036292742854 1.0293448485615344 1.033717395374647 1.0 13.408700276066677 -9.702403934990686 13.446659005443031 0.9999984443094517 1.0300211517046827 0.04757146557488856 0.03954239049565893 0.0 0.0 0.038918688046301185 0.00943916833090372 1.9842485198200668e-10 9.702403934990686 0.03002270739523094 IRPVS(ph)LPVDR ddPTM_A459_Selumetinib_30min_R2 2 IRPVSLPVDR 10 1 Q52LW3 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 IRPVS(1)LPVDR;IRPVS(1)LPVDR 73.219 0.036223000000000005 9465300.0 28545.0 22893.8 28918.0 33769.0 34259.0 34864.0 28397.0 30772.0 26412.0 35103.0 True False 26958.58317468871 24649.68084483055 27057.447363537773 29169.603945225783 29955.07814065408 39666.19953611874 29717.516767587993 30861.541425421165 31695.138012939635 34089.48518145281 0.7908181373579724 0.723087506708426 0.793718274697179 0.8556774556717623 0.8787189944702318 1.163590453918033 0.8717502364558005 0.9053096947973892 0.9297628827256131 1.0 15.057039191647629 -6.077456996873466 1.8868723262036968 0.9621193219803137 0.7621431120449138 0.5483279954518413 0.07876569976396261 0.2735404482921384 1.9368548616205732 0.027001101997673596 0.04090034863441206 8.366484352087979e-07 6.077456996873466 -0.19997620993539988 IRQEVGPPLPPLLAPLIAT(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 IRQEVGPPLPPLLAPLIATPPR 22 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 IRQEVGPPLPPLLAPLIAT(1)PPR 130.62 3.3335e-05 18429000.0 2484.1 2713.1 3393.2 3205.7 2914.9 2513.0 2521.0 2379.9 1311.8 2095.7 True False 2541.974696782819 2395.4489907140296 2932.422077513426 2645.884673441771 2651.247809667395 2487.721501621438 2330.8389403312553 2316.7773209953134 2226.0287899187597 2364.7035088466714 1.074965502978683 1.0130018337403972 1.240080232698452 1.1189075770146928 1.1211755722223624 1.0520225864741775 0.98567914819396 0.979732686287283 0.9413564032830708 1.0 11.207443591638475 -7.082274412943661 2.1885483041528984 0.9717976406227092 1.1157644151172086 0.5831124612333914 0.05449936211293204 0.23923973830041437 2.2633341732675003 0.025605804137140937 0.01897120116545645 8.274191861191982e-08 7.082274412943661 0.14396677449449935 IRQEVGPPLPPLLAPLIAT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 IRQEVGPPLPPLLAPLIATPPR 22 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 IRQEVGPPLPPLLAPLIAT(1)PPR;IRQEVGPPLPPLLAPLIAT(1)PPR 135.08 2.4753e-05 42203000.0 146560.0 148481.0 164696.0 172657.0 179076.0 134956.0 108970.0 127505.0 106107.0 157422.0 True False 138414.78192616507 159869.01525833554 154099.63866744612 149140.8187500619 156578.8719202479 153544.96399140783 114037.32091995858 127876.01844041102 127331.36487729034 152876.81782852358 0.9054007264948434 1.0457374605851284 1.0079987329425848 0.9755620300610116 1.0242159285123058 1.0043704871175019 0.7459425342557179 0.8364644179331685 0.8329017223534398 1.0 17.222010128097757 -7.23919926028293 24.450336793331843 0.8401992048503728 0.9974259388613316 0.4979096932704862 0.06829803080367489 426.62996964140257 469028.8068673806 0.024593313426533724 0.019033099106843247 5.765018957025018e-08 7.23919926028293 0.15722673401095877 IRQEVGPPLPPLLAPLIATPPR ddPTM_A459_Selumetinib_30min_R1 1 IRQEVGPPLPPLLAPLIATPPR 22 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 0 154.84 6.1502e-08 2605600.0 385.61 651.26 565.62 619.97 606.35 467.92 557.68 541.36 225.51 355.55 False True 394.59396273355486 575.0101764374398 488.81191072826374 511.70387777823714 551.5057495597875 463.2131496373672 515.6137486092563 527.0013742148925 382.6739994012649 401.18830585028104 0.9835629727472985 1.4332675405848623 1.2184101669969485 1.2754705715903873 1.3746805216341558 1.1546028208764219 1.2852162964133793 1.3136010360470565 0.9538513307117046 1.0 8.648135743537155 -8.264938903868691 24.982137310072407 0.9769256210863835 1.261936125815895 0.4726713341219748 0.11723121787139991 247.0419320645015 1763522.77917561 0.09152586826229224 0.027316150793647645 5.433267608040698e-09 8.264938903868691 0.2850105047295115 IRS(ph)EDEEDLGNARPSAPSTLFDFLESK ddPTM_A459_Selumetinib_30min_R1 1 IRSEDEEDLGNARPSAPSTLFDFLESK 27 2 Q9H7E2-2;Q9H7E2;Q9H7E2-3 Q9H7E2-2 TDRD3 Tudor domain-containing protein 3 1 IRS(0.917)EDEEDLGNARPS(0.031)APS(0.026)T(0.026)LFDFLESK 42.042 0.031505 11711000.0 1521.9 1656.5 2438.4 2480.9 2211.9 1941.5 2599.9 2734.8 1553.8 1838.8 True False 1557.3573088981025 1462.5562099140425 2107.2786731724445 2047.6573872607212 2011.8340355426626 1921.9702727409558 2403.7874498085016 2662.264220117645 2636.685114938075 2074.827891428762 0.7505959001860533 0.7049048337724538 1.0156402282221761 0.9869046949482972 0.969638996975927 0.9263275670626608 1.1585478775076676 1.283125328667316 1.2707970265053687 1.0 11.01877595342031 -5.522619047776712 0.46033748216506054 1.193307389935702 0.5712331277782455 0.632233375161999 0.11086959128842629 1.7374326542893654 0.4672445618603926 0.0934810453506991 0.5508030824501365 3.0017944632707623e-06 5.522619047776712 -0.6220742621574565 IRS(ph)FPDFPTPGVVFR ddPTM_A459_Selumetinib_30min_R1 1 IRSFPDFPTPGVVFR 15 1 H3BSW3;H3BQF1;H3BQZ9;H3BQB1;P07741-2;P07741 H3BSW3 APRT Adenine phosphoribosyltransferase 1 IRS(1)FPDFPTPGVVFR 82.765 0.013618 3888100.0 783.0 751.48 1202.4 1284.4 1165.3 824.26 611.98 844.37 534.2 516.95 True False 801.2423765472198 663.4963722464257 1039.1206843104278 1060.1036511740372 1059.8988207504246 815.9686927682006 565.8178558920753 821.9745646996985 906.4983835756984 583.3055680194145 1.373623741099882 1.1374764936657389 1.781434536684968 1.817407049230761 1.8170558946475672 1.3988700562876202 0.970019637928851 1.4091663268202168 1.5540711991721068 1.0 9.1881080354259 -6.995279237612308 24.866086959311108 1.2555590992459333 1.5866619004011266 0.296457301220135 0.2551395254418327 183.09707077389388 964434.9379287715 0.09795878658278315 0.08608023983052952 1.0109292497265124e-07 6.995279237612308 0.3311028011551933 IRSS(ph)VEKENQK ddPTM_A459_Selumetinib_30min_R1 2 IRSSVEKENQK 11 2 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 IRS(0.101)S(0.899)VEKENQK;IRS(0.277)S(0.723)VEKENQK 149.82 0.020392 66190000.0 6749.1 7062.2 10333.1 10717.2 7544.2 7936.9 6263.6 6718.9 4581.4 5344.6 True False 6906.340898537473 6235.354340872295 8929.921775655424 8845.642206759887 6861.828442036692 7857.061992128614 5791.131609146707 6540.692945936977 7774.301187783047 6030.6314708125765 1.1452102374292326 1.0339471697202107 1.4807606498382486 1.4667854020879196 1.137829176802959 1.302858917868835 0.9602861055554438 1.0845784521228046 1.2891355118298293 1.0 12.558093360106088 -7.240753327897492 24.699441119736747 1.0905482069884296 1.2646135113064427 0.2415293463288588 0.1540239945216723 1130.4463075177646 1349770.557613437 0.06263624173421563 0.048454633054230305 5.744426435124691e-08 7.240753327897492 0.17406530431801315 IRSS(ph)VGPVR ddPTM_A459_Selumetinib_30min_R1 3 IRSSVGPVR 9 1 Q9NTI2 Q9NTI2 ATP8A2 Phospholipid-transporting ATPase IB 1 IRS(0.186)S(0.814)VGPVR;IRS(0.183)S(0.817)VGPVR;IRS(0.051)S(0.949)VGPVR 73.632 0.035126 84756400.0 6091.0 7133.7 8155.8 7944.400000000001 7094.5 6256.9 6522.3 5933.4 3718.4 5556.7 True False 6232.908448977159 6298.4830876328415 7048.287156602621 6557.059674857541 6452.80372763571 6193.9612668106565 6030.317659866145 5776.0269576005685 6309.85321880921 6269.956571841532 0.9940911675479928 1.0045497150521618 1.1241365192634 1.0457902857422319 1.029162427793415 0.9878794527266469 0.9617798131088166 0.9212228013732648 1.0063631456630584 1.0 12.614239735056891 -6.796743127655001 2.5110661232731335 0.9663528065944418 1.0446827959954588 0.40410273791708284 0.039137311158846375 0.27617838987225574 3.5661686799646235 0.01570154642932432 0.014224266767874473 1.596823341770049e-07 6.796743127655001 0.07832998940101699 IRSS(ph)VGPVR ddPTM_A459_Selumetinib_30min_R2 2 IRSSVGPVR 9 1 Q9NTI2 Q9NTI2 ATP8A2 Phospholipid-transporting ATPase IB 1 IRS(0.042)S(0.958)VGPVR;IRS(0.111)S(0.889)VGPVR 93.839 0.013218 131818000.0 97625.0 107885.0 108565.0 109686.0 114275.0 88432.0 80337.0 75674.0 85142.0 96886.0 True False 92199.39332383909 116159.43259504961 101580.04609663456 94746.5775810963 99918.75286853798 100612.70529423036 84072.8296847455 75894.19881149482 102172.7790662467 94088.64943994085 0.9799204672683953 1.2345743433079788 1.0796206205667311 1.0069926409303538 1.0619639400002083 1.0693394569177441 0.8935491176160553 0.806624383103086 1.0859203493134009 1.0 16.521733070787988 -7.249427388275822 22.440563210658915 0.9304088350327204 1.076381218935732 0.30113375533859377 0.09226074318092364 208.28170389531408 389108.30096741766 0.03513730961052856 0.026938597945588165 5.630832540453592e-08 7.249427388275822 0.1459723839030116 IS(ph)AEGGEQVER ddPTM_A459_Selumetinib_30min_R2 1 ISAEGGEQVER 11 0 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 IS(1)AEGGEQVER 79.639 0.045302 5100300.0 7966.6 8453.4 11381.0 13923.0 13827.0 8825.4 7760.3 11687.0 11281.0 11481.0 True False 7523.848264826596 9101.748598034867 10648.758850695876 12026.663381485338 12089.928645051628 10041.018740995358 8121.16932674273 11721.007235113004 13537.515217475835 11149.513698779589 0.6748140293912681 0.8163359267437047 0.9550872924494882 1.0786715641958233 1.084345826345321 0.9005790756680656 0.728387761668176 1.0512572612378575 1.2141798811330788 1.0 13.444693165958785 -5.054255651159422 2.1030714352763744 0.9981891968982555 0.6640476293300935 0.440968115436996 0.12109753203161076 0.4381902353805532 3.1715691080722497 0.036244515546622315 0.22486083531121945 8.825602208579183e-06 5.054255651159422 -0.33414156756816193 IS(ph)APNVDFNLEGPK ddPTM_A459_Selumetinib_30min_R1 4 ISAPNVDFNLEGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(1)APNVDFNLEGPK;IS(1)APNVDFNLEGPK;IS(1)APNVDFNLEGPK;IS(1)APNVDFNLEGPK 222.96 4.248e-09 1653010000.0 29578.800000000003 25910.2 29682.4 27239.6 22480.2 24636.1 21336.4 22036.7 14025.099999999999 18673.7 True False 30267.928489674214 22876.621738674807 25651.69311375238 22482.715210619994 20446.869879201666 24388.283201789072 19726.9781699658 21452.215130710298 23799.57034722489 21070.65129224129 1.436497053169855 1.085710233698306 1.2174133944876178 1.0670156749686546 0.9703957222589832 1.157452746169712 0.9362301096610971 1.0181087823616306 1.1295128003939987 1.0 14.362947287988712 -1.522878772662949 0.7742161754350525 1.0401772793689694 78.0163885955071 0.6523335773415101 0.0818656512320943 262.767033493382 1.02380138895309 0.028922230447463837 35379.557984747094 0.02999999810847628 1.522878772662949 76.97621131613812 IS(ph)APNVDFNLEGPK ddPTM_A459_Selumetinib_30min_R2 4 ISAPNVDFNLEGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(1)APNVDFNLEGPK;IS(1)APNVDFNLEGPK;IS(1)APNVDFNLEGPK;IS(1)APNVDFNLEGPK 210.57 4.2809e-06 227155000.0 613416.0 677239.0 529292.0 578036.0 514625.0 675662.0 726972.0 593790.0 422774.0 638282.0 True False 579324.7944188069 729181.0536333941 495237.9289695574 499306.4996322812 449973.206694127 768728.3074510392 760777.6384676889 595517.830592774 507340.6132925384 619853.1402042017 0.9346162128467345 1.1763771228023074 0.7989601033664335 0.8055238688760887 0.7259351893351541 1.2401781286415565 1.2273514307228672 0.9607402011331091 0.8184851868708809 1.0 19.241566917361453 -6.758589761314908 24.999469466763045 1.0580222629174172 0.8947277293694732 0.19906875842953187 0.16081007608429507 140.63645946594772 1233795.1440383245 0.05955186069860855 0.05705023144932009 1.743452978018671e-07 6.758589761314908 -0.163294533547944 IS(ph)ASSATR ddPTM_A459_Selumetinib_30min_R1 3 ISASSATR 8 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30;P49023-2;P49023-3;A0A1B0GU60;P49023-4 A0A1B0GTU4 PXN Paxillin 1 IS(0.847)AS(0.146)S(0.008)ATR;IS(0.632)AS(0.367)S(0.001)ATR;IS(0.491)AS(0.491)S(0.018)ATR 128.6 0.0042872 369374000.0 11054.2 10472.7 11902.0 11853.5 10311.6 9377.8 9199.3 8742.5 5090.51 6827.4 True False 11311.741352271112 9246.551415373853 10285.773773006245 9783.508742752614 9378.917600660843 9283.467846361136 8505.389394601083 8510.620500357805 8638.223673859848 7703.763294507686 1.4683396828061546 1.2002642165766024 1.3351622291327896 1.2699648689527703 1.2174462327194606 1.2050562162235285 1.1040564292343857 1.1047354617483327 1.1212992071054904 1.0 12.911347660340056 -1.5228787452804526 0.13153955994082514 0.9267290967715335 2.499417055035177 0.7997449284039189 0.05658781779465819 35.106176220925526 0.31293348647598807 0.28625016368859413 10.255710089232426 0.02999999999999205 1.5228787452804526 1.5726879582636437 IS(ph)ASSATR ddPTM_A459_Selumetinib_30min_R2 2 ISASSATR 8 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30;P49023-2;P49023-3;A0A1B0GU60;P49023-4 A0A1B0GTU4 PXN Paxillin 1 IS(0.991)AS(0.009)SATR;IS(0.923)AS(0.076)S(0.001)ATR 114.86 0.010127 408110000.0 173369.0 237000.0 210963.0 207787.0 288050.0 225420.0 200705.0 177417.0 185314.0 240770.0 True False 163733.84503109526 255177.1379248896 197389.870259147 179486.0521474319 251862.5838003272 256469.5588409786 210038.18018941244 177933.25409703457 222381.97810578175 233818.34450441215 0.7002609028737076 1.0913478087690183 0.8442018126401637 0.767630326559108 1.0771720428273521 1.0968752660727996 0.8982964131176159 0.7609892819751659 0.9510886691851733 1.0 17.835028597152075 -4.732602593021856 24.350515282104404 0.9346240447681379 0.7002590632697986 0.26784399550425675 0.11970157076632532 3744.874104790824 3162029.5977286818 0.031281005024636405 3.185060469832424 1.8509615914484062e-05 4.732602593021856 -0.2343649814983393 IS(ph)DAELEAELEK ddPTM_A459_Selumetinib_30min_R1 4 ISDAELEAELEK 12 0 Q8WUX9 Q8WUX9 CHMP7 Charged multivesicular body protein 7 1 IS(1)DAELEAELEK;IS(1)DAELEAELEK;IS(1)DAELEAELEK;IS(1)DAELEAELEK 225.33 4.8345e-09 201607000.0 16261.699999999999 18120.5 15087.7 16852.8 14678.599999999999 15255.3 16828.3 18923.8 9790.96 13632.2 True False 16640.56597023999 15998.9434360081 13038.873210803768 13909.77484623624 13350.923221717312 15101.845532704157 15558.927782457935 18421.87935083454 16614.544016574917 15382.025658872732 1.0818188929909438 1.040106406712403 0.8476694487427684 0.9042875856999197 0.867956114350659 0.9817852256664934 1.011500573949645 1.197623756413925 1.0801271812331972 1.0 13.908957883861921 -7.482882065309274 3.4565471276569952 1.1049996656115069 0.9477017307997533 0.35425620244527833 0.08196018260847858 0.2501705913594917 6.113464436271262 0.04168940479319601 0.024975972078367267 3.289409441952388e-08 7.482882065309274 -0.15729793481175358 IS(ph)DAELEAELEK ddPTM_A459_Selumetinib_30min_R2 4 ISDAELEAELEK 12 0 Q8WUX9 Q8WUX9 CHMP7 Charged multivesicular body protein 7 1 IS(1)DAELEAELEK;IS(1)DAELEAELEK;IS(1)DAELEAELEK;IS(1)DAELEAELEK 223.58 1.4412e-08 42480600.0 86333.0 84103.0 85559.0 92384.0 88602.0 77745.0 80347.0 77154.0 63848.3 85163.0 True False 81534.9574783816 90553.42966623217 80054.22708959566 79801.13982871102 77471.02464807013 88453.66805115729 84083.29470456013 77378.50536646773 76619.74407055772 82704.12290995239 0.9858632751254279 1.0949082884879398 0.9679593262449332 0.9648991733531578 0.9367250618499392 1.0695194500456158 1.0166759738944258 0.9356063838645244 0.9264319767223782 1.0 16.33567163099533 -5.292847115786006 24.76828238214795 0.9777456401744864 1.040385817343721 0.21916842915156487 0.04767700743518349 814.9975071737424 642709.7070952035 0.012984346331112527 0.02703357684658334 5.095102018125846e-06 5.292847115786006 0.06264017716923465 IS(ph)DAELEAELEKLSLSEGGLVPSSK ddPTM_A459_Selumetinib_30min_R1 1 ISDAELEAELEKLSLSEGGLVPSSK 25 1 Q8WUX9 Q8WUX9 CHMP7 Charged multivesicular body protein 7 1 IS(1)DAELEAELEKLSLSEGGLVPSSK 102.21 1.2193e-06 8461400.0 935.96 818.1 2050.9 2142.2 1006.6 1107.1 968.93 798.89 751.76 672.22 True False 957.7660469388707 722.3164716756279 1772.3990447873061 1768.1049840742933 915.5532077296639 1095.9635791663727 895.8428300099818 777.7008420395584 1275.681813621991 758.5059849772914 1.262700711540918 0.9522884274898016 2.3366975078520564 2.3310362991100564 1.2070480996363848 1.4448977343259648 1.1810623090031414 1.0253061379111488 1.6818348686598474 1.0 9.567016753850188 IS(ph)DAHLADTMIGK ddPTM_A459_Selumetinib_30min_R2 2 ISDAHLADTMIGK 13 0 Q9Y657 Q9Y657 SPIN1 Spindlin-1 1 IS(1)DAHLADTMIGK;IS(1)DAHLADTMIGK 120.21 0.0020374000000000004 6181500.0 47543.0 46839.0 52102.0 57229.0 55676.0 46765.0 47955.0 48984.0 36359.0 53565.0 True False 44900.750389708395 50431.400688877235 48749.81404436839 49434.311474468486 48681.48313024482 53206.454259597085 50185.002521029775 49126.53533026224 43631.81595534121 52018.43927141612 0.8631698878051718 0.9694908458468311 0.9371641042517047 0.9503228502596078 0.93585051401177 1.0228383435724064 0.9647540991989391 0.9444061763163477 0.8387759526517875 1.0 15.666735493763717 -4.754182909173427 24.824708486251666 0.9514420244397871 0.8631697183805307 0.24930466424704212 0.04598873647576686 347.66392923820325 1189262.6068147027 0.01143234353427621 0.11353526261857033 1.761234121891491e-05 4.754182909173427 -0.0882723060592564 IS(ph)DSESEDPPR ddPTM_A459_Selumetinib_30min_R2 2 ISDSESEDPPR 11 0 Q96ST2;Q96ST2-3;B8ZZB6 Q96ST2 IWS1 Protein IWS1 homolog 1 IS(0.792)DS(0.206)ES(0.002)EDPPR;IS(0.838)DS(0.161)ES(0.002)EDPPR 167.84 3.1432e-05 37252000.0 420407.0 338291.0 436546.0 416510.0 489270.0 310893.0 398070.0 437474.0 393708.0 335229.0 True False 397042.46196256316 364236.8319229905 408459.10563534766 359780.61948017456 427803.52847070346 353715.6887443368 416581.04376074136 438746.9769122803 472460.6011206428 325550.0677404558 1.2196049127506388 1.1188350672173033 1.2546736926529867 1.105146811909156 1.3140944231403726 1.0865170177950507 1.279622046010016 1.3477096778307862 1.4512686309661933 1.0 18.312519913146026 -7.495813563176895 22.71117705100976 1.3024266824745585 1.185645993899964 0.08176194042034479 0.126037207289631 403.9631600252919 338978.9097719924 0.04937346681855197 0.03313898505587034 3.192908233815458e-08 7.495813563176895 -0.11678068857459456 IS(ph)EDETER ddPTM_A459_Selumetinib_30min_R2 1 ISEDETER 8 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 IS(1)EDETER 145.9 0.0019262 14287000.0 39776.0 29392.0 34775.0 43424.0 42226.0 36461.0 50963.0 57131.0 42627.0 30368.0 True False 37565.40915594388 31646.271889824315 32537.614360157222 37509.57628942179 36921.192374770384 41483.17178999613 53332.88048126869 57297.241751453796 51153.591097894016 29491.19693446029 1.2737838087557891 1.0730751946132722 1.1032992127266699 1.2718906042634055 1.251939433208565 1.4066289639646088 1.8084339065583848 1.942859148063343 1.734537638861356 1.0 14.847996756590243 -6.973745351843646 2.6587397310813015 1.6975949371125547 1.183345346463418 0.3844112785776699 0.2457254323555387 0.23863940166942985 3.4165594328653976 0.09566236866809398 0.07799435791895276 1.0623182639226883e-07 6.973745351843646 -0.5142495906491367 IS(ph)EDETERNGDDGTHDK ddPTM_A459_Selumetinib_30min_R1 2 ISEDETERNGDDGTHDK 17 1 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 IS(0.997)EDET(0.003)ERNGDDGTHDK;IS(1)EDETERNGDDGTHDK 105.92 0.0014322 84375000.0 6312.700000000001 7673.2 7662.1 6592.6 6207.5 5517.9 6576.6 6518.700000000001 6192.799999999999 7268.299999999999 True False 6459.773627624054 6774.818176826096 6621.628904902633 5441.326168428808 5646.032721023141 5462.394935852341 6080.521767148963 6345.802900278227 10508.72929578357 8201.257104237373 0.7876565196677543 0.826070697542908 0.8073919425695619 0.6634746477606974 0.6884350349297043 0.6660436158049559 0.7414133821030092 0.7737597809242583 1.281355914370004 1.0 13.001629350373861 -8.199233068430903 7.197771358682394 1.1390968920032964 0.7407701614852061 0.7854919501982475 0.0828754802071623 0.10130500896007208 10.183629446539186 0.05760399050209639 0.021335959833124463 6.320725523509204e-09 8.199233068430903 -0.3983267305180903 IS(ph)EDETERNGDDGTHDK ddPTM_A459_Selumetinib_30min_R2 2 ISEDETERNGDDGTHDK 17 1 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5;G3V3T3 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 IS(0.999)EDET(0.001)ERNGDDGTHDK;IS(0.983)EDET(0.007)ERNGDDGT(0.011)HDK 110.61 0.0011619999999999998 105358000.0 100191.0 75601.0 72807.0 72897.0 77781.0 57724.0 62936.0 70776.0 50213.0 70172.0 True False 94622.78531635087 81399.35360447093 68122.67688626795 62968.30284566097 68009.45540903744 65674.95703369993 65862.6487053182 70981.94644240252 60257.00306844382 68145.9520312482 1.3885312699566037 1.1944855296341799 0.9996584515398715 0.9240211776157586 0.9979969958868845 0.9637396657630493 0.9664939257891211 1.0416164764981766 0.8842345182999729 1.0 16.05634034093955 -4.990253210996159 1.945885189981983 0.9692658808175788 1.4292800687292728 0.9149814793267013 0.041144011397366405 0.12495221831121649 0.6987585816921374 0.010920093122214715 0.08975054658795192 1.0226965455655399e-05 4.990253210996159 0.460014187911694 IS(ph)FFLEK ddPTM_A459_Selumetinib_30min_R1 1 ISFFLEK 7 0 Q96FF9;B5MBX0 Q96FF9 CDCA5 Sororin 1 IS(1)FFLEK 106.18 0.017233000000000002 3268900.0 2499.6 3188.6 2140.1 2235.9 2146.7 2047.6 2287.5 3061.5 1796.3 2793.3 True False 2557.835816625071 2815.2772296600774 1849.4861747278326 1845.4420380411325 1952.5313640306667 2027.0030030720477 2114.952033323186 2980.299074846485 3048.189903438839 3151.847264046099 0.8115354591584867 0.8932149922918666 0.5867943525770993 0.5855112521131801 0.6194879384872721 0.6431158724582159 0.6710198357163326 0.9455721756709131 0.9671121878938408 1.0 11.62198190932243 -7.785904654284301 5.838292497159978 0.9717212727167797 0.6826417663209233 0.6617301779498006 0.09298159746196724 0.11940263217803229 12.218655612136496 0.05696478246576104 0.028086439961619164 1.637175910233497e-08 7.785904654284301 -0.28907950639585633 IS(ph)FVEEDVHPK ddPTM_A459_Selumetinib_30min_R1 2 ISFVEEDVHPK 11 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 IS(1)FVEEDVHPK;IS(1)FVEEDVHPK 147.96 0.00043477 24284000.0 14581.7 26075.0 17218.2 18263.8 16268.3 18036.5 19026.699999999997 17955.5 10188.0 15391.9 True False 14921.425238950946 23022.126878061383 14880.063012802573 15074.370183986597 14796.835137401647 17855.069185831697 17591.500700515942 17479.26181231621 17288.291897920662 17367.600294802243 0.8591529621634956 1.3255790372462348 0.8567713881149063 0.8679592993914098 0.8519792536813522 1.0280677170567625 1.0128918446943247 1.0064293002843567 0.9954335431760647 1.0 14.084110808211745 -10.159135322074132 18.432731271484386 0.9999999999985313 0.9812493853379551 0.0018854209916731035 0.1351070123678125 0.0 0.0 0.13099757206679205 0.03177157801946149 6.932097747185089e-11 10.159135322074132 -0.018750614660576148 IS(ph)FVEEDVHPK ddPTM_A459_Selumetinib_30min_R2 4 ISFVEEDVHPK 11 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 IS(1)FVEEDVHPK;IS(1)FVEEDVHPK;IS(1)FVEEDVHPK;IS(1)FVEEDVHPK 113.69 0.0045976 17868200.0 134512.0 116331.0 131470.0 128551.0 123550.0 115716.0 135601.0 154076.0 107984.0 136695.0 True False 127036.36153419969 125253.21363687929 123011.36333371293 111042.13203715593 108028.54444898604 131654.82863473822 141906.71518828414 154524.3356513449 129583.81732505203 132748.26017373707 0.9569719510292503 0.9435393991073895 0.926651416543759 0.8364865339238887 0.8137850116272817 0.9917631196253134 1.0689911491311506 1.1640403832721269 0.9761620766664398 1.0 17.018333427329367 -6.98699248254742 5.160523644437718 1.062312573658665 0.8963387153843111 0.58345332872411 0.0625055922330111 0.1273984760989376 9.995350503283296 0.024236852312789565 0.02045932305289581 1.0304039561410366e-07 6.98699248254742 -0.16597385827435385 IS(ph)GLIYEETR ddPTM_A459_Selumetinib_30min_R1 2 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 1 IS(0.968)GLIY(0.032)EETR;IS(1)GLIYEETR 89.189 0.031193 3908300.0 2560.35 2425.13 2847.22 3391.0 2879.95 2617.91 3171.3599999999997 4380.1 1670.0100000000002 2897.55 True False 2620.0011734261484 2141.19465218765 2460.58316265996 2798.825506953565 2619.4590309964683 2591.5762022720987 2932.1417619234157 4263.925519430051 2833.884997295493 3269.4787670270885 0.8013513346069212 0.6549039785123368 0.7525918771747673 0.856046393443477 0.8011855153836408 0.7926572970616349 0.8968223900073189 1.3041606394364829 0.8667696593950731 1.0 11.674844938683982 -7.529922228522919 24.990656477148224 1.0713774606500306 0.7804340123014996 0.5583909370204284 0.11154141676788695 119.8139400123365 425098.8458316736 0.050148422377432146 0.029034486724361663 2.951737763090895e-08 7.529922228522919 -0.29094344834853103 IS(ph)INQTPGK ddPTM_A459_Selumetinib_30min_R1 1 ISINQTPGK 9 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 IS(0.603)INQT(0.397)PGK 108.9 0.01174 51927000.0 5730.6 6358.2 6936.9 6809.9 5263.5 5315.6 5799.3 4728.5 2942.2 4448.3 True False 5864.11183019348 5613.778988153012 5994.907081664173 5620.678802654998 4787.417354346403 5262.12989017864 5361.854131956782 4603.084819667357 4992.698510214193 5019.28263511125 1.168316721033484 1.118442493929929 1.1943752758069779 1.1198171554111773 0.9538050957435857 1.0483828612018395 1.0682510872069948 0.9170802192862231 0.9947036007275037 1.0 12.293265471005139 -6.12582827064028 4.793018830546935 0.9994829545867817 1.156290212933517 0.7481944116670276 0.043896839662157947 0.11982674665334458 4.160186802837855 0.013548535577420367 0.017802416448882835 7.484654012890611e-07 6.12582827064028 0.15680725834673537 IS(ph)IVEPGY(ph)FRTGMTNMTQS(ph)LERMK ddPTM_A459_Selumetinib_30min_R1 1 ISIVEPGYFRTGMTNMTQSLERMK 24 2 O14756 O14756 HSD17B6 17-beta-hydroxysteroid dehydrogenase type 6 3 IS(0.882)IVEPGY(0.873)FRT(0.235)GMT(0.049)NMT(0.194)QS(0.767)LERMK 44.105 0.038197 7263700.0 534.99 655.39 803.86 1017.4 832.7 836.03 780.4 689.12 392.29 620.65 True False 547.4542260906728 578.6566341174548 694.70022728691 839.7301889633029 757.3824320251258 827.6202972545051 721.533799696355 670.8422990227697 665.6874782720157 700.316473142953 0.7817240448932337 0.8262787701116032 0.9919804173235598 1.1990724496236316 1.0814859582355192 1.1817804221286197 1.0302967691994744 0.9579130646635998 0.9505523628260154 1.0 9.451863213340014 -5.3076178102520615 3.328934578339075 1.0623233249232558 0.7944803568686029 0.6119177722391631 0.0793723243114697 0.1647454195829644 3.6808066594355475 0.023388751863540263 0.06067984212268937 4.924727330708174e-06 5.3076178102520615 -0.2678429680546529 IS(ph)LPLPNFSSLNLR ddPTM_A459_Selumetinib_30min_R2 2 ISLPLPNFSSLNLR 14 0 P08670;B0YJC4 P08670 VIM Vimentin 1 IS(0.881)LPLPNFS(0.09)S(0.029)LNLR;IS(0.999)LPLPNFSSLNLR 119.0 0.0022767 152356000.0 745414.7 610926.3 584146.4 737977.2 670063.3 565946.8 793476.4 590481.2 607977.7 613658.5 True False 703987.5351054692 657782.3827723323 546563.0565945123 637463.4322783237 585883.9578120935 643900.8345464632 830374.6248436584 592199.4025325744 729590.2283162813 595940.5846287371 1.1813049039847552 1.1037717513099428 0.917143538621411 1.0696761534968369 0.9831247827786244 1.0804782408763194 1.393384921688075 0.99372222299897 1.22426672580255 1.0 19.184808975368554 -7.015447502349819 24.981237923010166 1.1644076370820104 1.0459628776752434 0.12734074673520823 0.1244756147889407 1268.6645439954748 2051644.4825048093 0.04520208328909373 0.03615935328159349 9.650559610157182e-08 7.015447502349819 -0.11844475940676702 IS(ph)LPSDFQHK ddPTM_A459_Selumetinib_30min_R2 1 ISLPSDFQHK 10 0 Q5TCX8;Q5TCX8-2;G3V4P9;G3V347;A0A087WW79;J3KPI6;P80192;P80192-4 Q5TCX8 MLK4;MAP3K9 Mitogen-activated protein kinase kinase kinase MLK4;Mitogen-activated protein kinase kinase kinase 9 1 IS(0.999)LPS(0.001)DFQHK 138.42 0.0016385000000000002 4684000.0 23241.0 17127.0 20814.0 26149.0 25971.0 22569.0 24447.0 25272.0 21682.0 24174.0 True False 21949.358261094432 18440.58582801513 19474.849900569716 22587.46109045898 22708.29079631416 25677.674889016263 25583.83394081148 25345.537335995177 26019.00584569729 23476.033808404998 0.9349687617691206 0.7855068696234773 0.8295630369043531 0.9621497939047997 0.9672967325589739 1.0937824974431167 1.089785188997804 1.0796345559410827 1.1083220469882713 1.0 14.518901070438888 -6.258564121227582 1.441612722748373 1.0802830285088185 0.8446855555866462 0.7755565705479409 0.05069380477130479 0.17237555151818285 0.718884545689393 0.018640656779599727 0.025905878866156473 5.513607909379753e-07 6.258564121227582 -0.23559747292217237 IS(ph)LRT(ph)T(ph)ALENTSIK ddPTM_A459_Selumetinib_30min_R1 2 ISLRTTALENTSIK 14 1 O60307 O60307 MAST3 Microtubule-associated serine/threonine-protein kinase 3 3 IS(1)LRT(1)T(1)ALENTSIK;IS(1)LRT(1)T(1)ALENTSIK 137.98 0.022987 27467000.0 3897.0 4755.1 5074.799999999999 5159.8 4365.8 4316.700000000001 4124.3 4292.5 2598.6 3434.9 True False 3987.792517757999 4198.370681413984 4385.670033881038 4258.73779144176 3970.9141608445916 4273.2779172500095 3813.2007305070224 4178.6489559949505 4409.634405765277 3875.8028737593318 1.028894566531461 1.0832260613248832 1.1315513654148155 1.0988014432506474 1.0245397638071843 1.102552956493669 0.9838479547873423 1.0781376380842282 1.1377344383586143 1.0 11.920279480729338 -6.229403936392807 24.5557381806087 1.0572488263218889 1.0887284123720957 0.08469459119540979 0.049241625762754856 1470.439563931826 1127116.4990931523 0.01460428380085706 0.018852578060764916 5.896523905838803e-07 6.229403936392807 0.03147958605020684 IS(ph)MPDFDLHLK ddPTM_A459_Selumetinib_30min_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(1)MPDFDLHLK;IS(1)MPDFDLHLK 121.18 0.0029865 8153600.0 7127.9 8626.5 6394.5 7181.2 6449.299999999999 7043.9 6933.5 7058.1 3423.3 6197.5 True False 7293.9662015209815 7616.505369648955 5526.162022474242 5927.138227819214 5865.9619537163935 6973.044761349486 6410.500512807122 6870.896260060098 5809.090072060443 6993.009493762107 1.043036793819218 1.0891598783675351 0.7902408866173684 0.8475804634766091 0.8388322594083333 0.9971450442859502 0.9167012455117365 0.9825378138252299 0.8306995832398424 1.0 12.771697748464954 -3.288697294015549 9.710601513992739 0.9297193873310462 0.9686172333010148 0.0 0.09745429355314551 0.0 0.0 0.023166291336855247 0.0 0.0005144020681343394 3.288697294015549 0.03889784596996859 IS(ph)MPDVDLHLK ddPTM_A459_Selumetinib_30min_R1 1 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(1)MPDVDLHLK 91.307 0.017597 7419600.0 4810.1 5194.6 3901.0 3725.2 4285.9 4110.4 4139.0 4846.0 2393.7 3236.7 True False 4922.165971174689 4586.413817095975 3371.2656266591657 3074.6637506645307 3898.2411017371005 4069.053107944595 3826.7918976719834 4717.468337973563 4061.9340710691704 3652.1619731278447 1.3477403267958477 1.2558078888182505 0.9230876536869176 0.8418749697542238 1.0673790293037044 1.11414913628809 1.0478154928037267 1.291691982087353 1.1121998698185835 1.0 11.834535034827164 -5.0793261484528625 5.532294707117997 1.0561596642918458 1.32772694803774 0.44715742744072684 0.11385049161017133 0.2002070459338183 10.312584618496567 0.03264992649120359 0.09315479687946626 8.330553379473097e-06 5.0793261484528625 0.27156728374589423 IS(ph)MPDVDLHLK ddPTM_A459_Selumetinib_30min_R2 1 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(1)MPDVDLHLK 85.45700000000002 0.02586 0.0 13101.0 13666.0 13425.0 14779.0 11151.0 10532.0 14361.0 13277.0 11238.0 11734.0 True False 12372.898867458296 14714.138256884144 12561.250116034813 12766.074704802984 9750.11168879517 11982.687400023011 15028.814955781647 13315.633871874326 13485.914015955463 11395.208931406638 1.0857983334870693 1.2912565575107724 1.1023273194591823 1.1203019428295051 0.8556325511437205 1.0515548659223972 1.318871382371966 1.1685291557204145 1.183472290603341 1.0 13.476139756240498 -10.654053509002889 14.957725104215273 0.9999999996902995 1.1306384403559724 0.09302577414705793 0.12257992936827553 0.0 0.0 0.12758141447474985 0.030943037872109325 2.2179231348016135e-11 10.654053509002889 0.13063844066567287 IS(ph)MSEVDLNVAAPK ddPTM_A459_Selumetinib_30min_R1 2 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(0.884)MS(0.116)EVDLNVAAPK;IS(1)MSEVDLNVAAPK 173.19 0.00041244 46533000.0 7278.3 6738.1 7316.8 7646.3 6586.7 6719.1 6768.6 6455.299999999999 3852.3999999999996 4437.3 True False 7447.870228893526 5949.200119542296 6323.218748305501 6311.0172438275 5990.934147976335 6651.511954454677 6258.039052568877 6284.08447423045 6537.241431836433 5006.870677962178 1.4875299778912698 1.18820726601304 1.2629083423578824 1.2604713901650275 1.196542617796287 1.3284768835215606 1.2498902917772046 1.255092227943883 1.3056541405413578 1.0 12.289693477317208 -11.505264729267196 2.643969941903782 0.7530884381678941 1.2748796601659758 0.5256328942442116 0.08003474678364653 17081134.873686817 7625512.351159681 25751730.027300894 0.01901843125924236 3.1241744096356304e-12 11.505264729267196 0.5217912219980817 IS(ph)MSEVDLNVAAPK ddPTM_A459_Selumetinib_30min_R2 5 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(0.987)MS(0.013)EVDLNVAAPK;IS(0.886)MS(0.114)EVDLNVAAPK;IS(1)MSEVDLNVAAPK;IS(0.797)MS(0.203)EVDLNVAAPK;IS(0.999)MS(0.001)EVDLNVAAPK 190.82 7.5273e-05 68748800.0 191344.0 189345.0 178766.0 201592.0 162418.0 203110.0 210484.0 179881.0 152324.0 219103.0 True False 180709.86649072106 203867.15265986588 167264.3901857046 174134.821834403 142013.59880465746 231086.55885099486 220271.92306613355 180404.4239290976 182793.05628816463 212776.92709203978 0.8492925852461078 0.9581262190692328 0.7861021045451603 0.8183914685405642 0.6674295034969999 1.086050832715687 1.0352246649884727 0.8478570792173392 0.8590830725226839 1.0 17.698982192124554 -6.7689069748498865 24.99975649987646 0.960483010842811 0.8222580760933668 0.3815176166587573 0.09506152227238956 221.52499270452134 741609.4048792693 0.03579319858265151 0.03218213761626444 1.7025231469455924e-07 6.7689069748498865 -0.1382249347494442 IS(ph)NLSPEEEQGLWK ddPTM_A459_Selumetinib_30min_R1 1 ISNLSPEEEQGLWK 14 0 F5GX09;Q5HYJ3-3;Q5HYJ3-2;Q5HYJ3 F5GX09 FAM76B Protein FAM76B 1 IS(0.698)NLS(0.302)PEEEQGLWK 95.554 0.0082134 3605200.0 2921.6 3865.3 3981.2 4271.1 3034.9 3521.4 3494.0 3098.2 1865.0 3074.3 True False 2989.667595556012 3412.7488790707803 3440.574907166228 3525.232563476669 2760.3938308551146 3485.97791317538 3230.444766964463 3016.025671628084 3164.7687857893648 3468.916351217884 0.8618448220887152 0.983808352101836 0.991829885421796 1.0162345258740566 0.7957510505798107 1.0049184126194066 0.9312547319944174 0.8694431823267238 0.9123220237577255 1.0 11.760269336834913 IS(ph)PDLNIK ddPTM_A459_Selumetinib_30min_R1 3 ISPDLNIK 8 0 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 IS(1)PDLNIK;IS(1)PDLNIK;IS(1)PDLNIK 132.32 0.0033446 23681200.0 9164.8 14167.5 8862.400000000001 8762.400000000001 8995.1 9837.3 11461.1 10689.3 5711.8 9907.3 True False 9378.322008403526 12508.762513707941 7658.93475767859 7232.211330619272 8181.494793213893 9738.345693553752 10596.579999615456 10405.785040260176 9692.507426633618 11178.998460274192 0.8389232757952719 1.1189519846665346 0.6851181512275418 0.6469462677108093 0.7318629501817842 0.8711286371636996 0.947900658298825 0.9308333905974032 0.8670282459629113 1.0 13.448503320760997 -6.994816101326638 6.968019116182867 0.928025682469848 0.805760801058148 0.20034745784261587 0.12399320328932391 0.2725459809583913 74.73448872567408 0.04969791647034788 0.04211444232986069 1.0120078905376856e-07 6.994816101326638 -0.1222648814117 IS(ph)PDLNIK ddPTM_A459_Selumetinib_30min_R2 3 ISPDLNIK 8 0 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 IS(1)PDLNIK;IS(1)PDLNIK;IS(1)PDLNIK 108.47 0.012862 39633700.0 102685.0 81317.0 92049.0 102959.0 91436.0 82690.0 100129.0 93858.0 78043.0 87449.0 True False 96978.1787806239 87553.75242463413 86126.66755537351 88935.80658581831 79948.99223178861 94079.79691491678 104785.1969018494 94131.11124097172 93653.78070361358 84924.12015021114 1.141939164151385 1.0309644924171342 1.0141602574514208 1.0472384809935202 0.9414167858363127 1.107810086798796 1.2338685018638829 1.1084143241575601 1.1027936531807652 1.0 16.37388674580079 -6.976812204961073 24.868745274818547 1.127523044780156 1.0334373499461207 0.21055111838457452 0.07025438751267245 278.2181807350467 298385.9116879842 0.024361907646555252 0.021484174069268086 1.054842926696808e-07 6.976812204961073 -0.0940856948340354 IS(ph)PEQVDTSSLPLVPQHSFASLPLNESER ddPTM_A459_Selumetinib_30min_R2 2 ISPEQVDTSSLPLVPQHSFASLPLNESER 29 0 Q9C0D2;Q9C0D2-3 Q9C0D2 CEP295 Centrosomal protein of 295 kDa 1 IS(1)PEQVDTSSLPLVPQHSFASLPLNESER;IS(0.826)PEQVDT(0.122)S(0.026)S(0.026)LPLVPQHSFASLPLNESER 100.33 5.6411e-08 3099000.0 4757.0 5065.7 4749.4 6945.6 7102.9 5978.799999999999 5499.1 4109.889999999999 3119.4 4905.7 True False 4492.624983779798 5454.222901207234 4443.828774755736 5999.597298171704 6210.570201268333 6802.325429857346 5754.819046259929 4121.849099471084 3743.3671633183367 4764.059694460675 0.9430244942151998 1.1448687151315575 0.9327819254495736 1.2593455336312491 1.3036298030626194 1.427842190509625 1.2079653521032159 0.8651967783408948 0.7857515235736592 1.0 12.217975775186286 -7.763918647914859 24.97594229720401 0.8691055121633033 1.181801640351989 0.43755385290800264 0.1505196282628959 62.669127636862115 631295.686599242 0.08491719077049956 0.043797807874620495 1.7221911457881826e-08 7.763918647914859 0.31269612818868575 IS(ph)PSSLSNNYNNMNNR ddPTM_A459_Selumetinib_30min_R1 3 ISPSSLSNNYNNMNNR 16 0 Q9Y4E8 Q9Y4E8 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 IS(0.724)PS(0.226)S(0.049)LS(0.001)NNYNNMNNR;IS(0.434)PS(0.283)S(0.283)LS(0.001)NNYNNMNNR;IS(0.866)PS(0.084)S(0.049)LS(0.001)NNYNNMNNR 212.43 2.9324e-08 14140500.0 2319.29 3061.65 3600.4800000000005 3522.17 3216.88 3211.33 2868.11 2893.01 1620.8700000000001 2332.99 True False 2373.324944447256 2703.19059467753 3111.5545920209643 2907.089128819416 2925.913771986294 3179.026935854347 2651.7661535713914 2816.27797697914 2750.498006339092 2632.4519917470034 0.9015643787191043 1.0268717542246921 1.1819986088164172 1.1043275007230624 1.1114784927357924 1.2076295962171049 1.0073369474106042 1.0698307075716667 1.0448426087017635 1.0 11.36219150559966 -4.875571691790118 3.541309784345902 1.0963490453629614 0.8961931310079452 0.4444927712133896 0.06406313860417301 0.22462713442946985 4.772544183328757 0.016320219854391582 0.10256304992712975 1.3317671807719589e-05 4.875571691790118 -0.20015591435501623 IS(ph)PSSLSNNYNNMNNR ddPTM_A459_Selumetinib_30min_R2 2 ISPSSLSNNYNNMNNR 16 0 Q9Y4E8 Q9Y4E8 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 IS(0.497)PS(0.346)S(0.156)LS(0.001)NNYNNMNNR;IS(0.979)PS(0.02)S(0.001)LSNNYNNMNNR 193.31 1.1537e-06 17830300.0 44587.0 43585.0 47736.0 55598.0 55756.0 43047.0 37052.0 46533.0 40846.0 51287.0 True False 42109.03303590284 46927.829352136345 44664.71773102701 48025.456488100426 48751.432815035696 48976.333508240685 38774.99141714516 46668.40332604713 49016.341332596225 49806.21105037092 0.8454574670078069 0.9422083784826845 0.8967700370914761 0.9642463354526296 0.978822355423333 0.9833378704256193 0.7785171889090405 0.9369996701585993 0.9841411402088814 1.0 15.604038043385568 IS(ph)QEHLADHFDSR ddPTM_A459_Selumetinib_30min_R2 1 ISQEHLADHFDSR 13 0 V9GY71;V9GYH5;P19174;P19174-2 V9GY71;P19174-2 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1 IS(1)QEHLADHFDSR 89.669 0.017438 0.0 9758.8 8764.8 11226.0 11483.0 13522.0 12623.0 14762.0 17445.0 15025.0 10123.0 True False 9216.444963571628 9437.031976726052 10503.731381944637 9918.995590720111 11823.245471786233 14361.703669814897 15448.462250348075 17495.762061824793 18030.419833576314 9830.722687287323 0.9375144897017538 0.9599530245044572 1.0684597375051195 1.0089792893402372 1.202683245970874 1.4609000911384518 1.5714472619927908 1.7797025323936333 1.8340889482003693 1.0 13.263081762168081 -6.693793202397094 1.631845245058104 1.6131981863738876 0.9872766581972132 0.577098862950643 0.2153525820642086 0.23820465221311046 1.3133984736478717 0.0870394496237354 0.08354317453719602 2.023982707237836e-07 6.693793202397094 -0.6259215281766743 IS(ph)RPGDSDDSR ddPTM_A459_Selumetinib_30min_R1 1 ISRPGDSDDSR 11 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYL7;M0R1W6;B4DVF8 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 IS(0.905)RPGDS(0.094)DDS(0.002)R 75.73899999999998 0.028984 7576700.0 2129.0 2684.8 2760.7 2842.1 2507.0 2153.2 2483.9 2045.6 1247.1 1752.7 True False 2178.601557687141 2370.462367870341 2385.81210343962 2345.780587824457 2280.242292646799 2131.540762949178 2296.5374232006357 1991.3440429547506 2116.2376154197937 1977.6761177437415 1.101596736766295 1.1986099981703349 1.206371499374481 1.1861298049655737 1.1529907613225587 1.0778007297681154 1.1612302957982177 1.0069111039408225 1.0700627855253326 1.0 10.949590461221954 -7.5539213597707935 0.7416168403508849 1.0077286667851297 1.1777823183543903 0.6349678296773466 0.043758852112698296 0.4139520544583845 0.43224902235206303 0.038325493874998895 0.0201063648365626 2.7930495491861843e-08 7.5539213597707935 0.17005365156926056 IS(ph)SIYAR ddPTM_A459_Selumetinib_30min_R1 1 ISSIYAR 7 0 G8JLG1;Q14683;V9GY57 G8JLG1 SMC1A Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 1A 1 IS(0.987)S(0.013)IYAR 80.455 0.04486 3128100.0 4416.6 5128.8 5238.2 4095.9 2334.0 2702.6 2221.5 2523.1 2436.9 3116.5 True False 4519.498186792401 4528.317711685569 4526.881211372989 3380.627954565353 2122.8901121011695 2675.414297764466 2053.930466460088 2456.179191816159 4135.241315866007 3516.533132280695 1.285214163149721 1.287722180154369 1.2873136811416928 0.9613525103836575 0.6036883578925191 0.7608102062810055 0.58407823535221 0.6984661026706069 1.1759426572455016 1.0 11.779938094901754 -5.892087030647527 3.4655896459346263 0.7752517551922269 1.2894619981002413 0.6159588257801452 0.16911244680774376 0.14766129012906243 3.4597091784141054 0.04964327693363924 0.07768785907802878 1.282073635160542e-06 5.892087030647527 0.5142102429080144 IS(ph)SIYAR ddPTM_A459_Selumetinib_30min_R2 1 ISSIYAR 7 0 G8JLG1;Q14683;V9GY57 G8JLG1 SMC1A Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 1A 1 IS(0.994)S(0.006)IYAR 85.86200000000002 0.035661 4304700.0 17716.0 19047.0 19600.0 22653.0 25092.0 19191.0 17621.0 17830.0 13010.0 17346.0 True False 16731.41564276705 20507.843654242082 18338.95733886646 19567.622321395353 21939.718634673864 21834.38605144718 18440.41141534909 17881.882348084608 15612.363529772241 16845.175909679532 0.9932467154084681 1.217431255345806 1.0886771047804005 1.1616157899634314 1.302433334760661 1.2961803526730025 1.0946998425081989 1.061543224241984 0.9268151079859668 1.0 14.040047873767339 -7.812674564764913 2.2864026922727327 0.971431764416663 1.1787206270926873 0.4546000871446182 0.08985672297579608 0.28792810091749654 2.9580034968374016 0.06554402397678447 0.026695078638817864 1.5393076766268298e-08 7.812674564764913 0.2072888626760243 IS(ph)SKSPGHMVILDQTK ddPTM_A459_Selumetinib_30min_R1 2 ISSKSPGHMVILDQTK 16 1 Q9NWH9;Q9NWH9-3 Q9NWH9 SLTM SAFB-like transcription modulator 1 IS(0.424)S(0.424)KS(0.153)PGHMVILDQTK;IS(0.529)S(0.236)KS(0.236)PGHMVILDQTK 70.615 0.018031 88529000.0 12498.0 12798.099999999999 26100.0 30022.0 23727.4 19744.5 17484.5 12400.5 4895.1 7728.1 True False 12789.17908312535 11299.692502324722 22555.763357037715 24779.221282736635 21581.260859412698 19545.888256571638 16165.630088148286 12071.59845749921 8306.627176041568 8720.076913068642 1.4666360412439032 1.2958248665662628 2.586647294731282 2.8416287527923525 2.4748934068539237 2.2414811763045948 1.853840310046017 1.38434541092266 0.9525864575337123 1.0 13.090125144619948 -7.80766801217549 1.9364316937950667 0.9819608416685907 2.1755717520432367 0.52893281775928 0.4475639805857782 0.31514783605982266 2.277247855045898 0.38426390725141335 0.15035328031387957 1.5571555134814653e-08 7.80766801217549 1.193610910374646 IS(ph)SKSPGHMVILDQTK ddPTM_A459_Selumetinib_30min_R2 2 ISSKSPGHMVILDQTK 16 1 Q9NWH9;Q9NWH9-3 Q9NWH9 SLTM SAFB-like transcription modulator 1 IS(0.333)S(0.333)KS(0.333)PGHMVILDQTK;IS(0.374)S(0.313)KS(0.313)PGHMVILDQTK 122.19 0.00062745 32349000.0 346030.0 438990.0 484170.0 551980.0 470350.0 259810.0 179601.0 178791.0 129998.0 520250.0 True False 326799.03786784183 472659.12142467295 453019.02932443644 476799.3717813884 411260.4280176488 295596.4691796408 187952.80237262978 179311.25220955652 156001.23244760427 505229.03072816523 0.6468334517453207 0.9355343669453225 0.8966607256742932 0.9437291659471698 0.8140079112732627 0.5850741964562293 0.37201504850531125 0.35491082519767875 0.3087732948020946 1.0 18.94657801396655 -6.840193903087261 2.9489502501549567 0.4566530201410131 0.8656875001761548 0.39090448590986715 0.19901789603939576 0.22189886493529587 3.9025519886864974 0.07157715157209232 0.06358314483280816 1.4447945572178456e-07 6.840193903087261 0.4090344800351417 IS(ph)SPTETER ddPTM_A459_Selumetinib_30min_R1 2 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 IS(0.998)S(0.002)PTETER;IS(0.782)S(0.109)PT(0.109)ETER 143.4 0.0020367 13587400.0 2665.6000000000004 2914.3 2539.1000000000004 2571.3999999999996 2641.1 2343.85 3146.9 3776.8 1524.79 2565.3 True False 2727.7032936452974 2573.092401178686 2194.3041662779506 2122.35326115612 2402.2129713240774 2320.272997045527 2909.526799416274 3676.626995224633 2587.4572637446454 2894.5812431380277 0.9423481548882638 0.8889342481847861 0.7580730965765177 0.7332159932243836 0.829899999186006 0.8015919409918201 1.0051632878896306 1.270175782400492 0.8938969220085086 1.0 11.499138934380529 -7.361928332983765 4.404510478647245 1.0735197604811686 0.8216326220411014 0.5071847053860681 0.10438000931075624 0.1740099046748446 5.720918287509986 0.04512445295577949 0.029698772041807528 4.345819327059541e-08 7.361928332983765 -0.25188713844006716 IS(ph)SPTETER ddPTM_A459_Selumetinib_30min_R2 1 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 IS(0.967)S(0.033)PTETER 154.01 0.00093963 84400000.0 228870.0 236720.0 239350.0 237310.0 269260.0 216070.0 196800.0 197020.0 215280.0 215290.0 True False 216150.32163920152 254875.66282523156 223950.4815845755 204987.9686174161 235433.1515850587 245831.68121182785 205951.58995180175 197593.29558158334 258342.01542577756 209074.01830940275 1.0338459239795486 1.219069040171449 1.0711540505867998 0.9804564444447621 1.1260756046533138 1.1758117206511451 0.9850654405418267 0.9450877597290477 1.2356485875899916 1.0 17.673654263360312 -7.540562581645155 0.010080416709128993 5.2800205040638334e-05 2.137971941688667 0.036483790334758015 0.09841549469485533 4150.809117520811 33.15539038655674 3480.4810814556035 3545.8513338056814 2.8802979701898954e-08 7.540562581645155 2.1379191414836263 IS(ph)TPLTGVR ddPTM_A459_Selumetinib_30min_R2 1 ISTPLTGVR 9 0 Q08999;F5H837;Q08999-2 Q08999 RBL2 Retinoblastoma-like protein 2 1 IS(0.591)T(0.409)PLTGVR 94.692 0.023041 14981000.0 91221.0 66822.0 90186.0 82644.0 86237.0 64840.0 73198.0 76612.0 49296.0 70210.0 True False 86151.30200659596 71947.03253340512 84383.53094709253 71387.74463114799 75403.13709143827 73771.12144108351 76601.85203908534 76834.9282362007 59156.577445323004 68182.85487251237 1.2635332176641887 1.0552070996136929 1.237606303004942 1.0470043351019562 1.1058958624191715 1.0819599968206086 1.1234767476708731 1.1268951465858374 0.8676166105970979 1.0 16.05712138712628 -4.797230149731195 0.17526744014863718 0.9492703619132524 1.4028347877025973 0.39099456825263523 0.08379846630118296 20.951313093635775 0.664043796426945 0.2569407972519315 2.1563297130569508 1.5950336521447388e-05 4.797230149731195 0.45356442578934486 IS(ph)TYGLPAGGIQPHPQTK ddPTM_A459_Selumetinib_30min_R2 2 ISTYGLPAGGIQPHPQTK 18 0 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 IS(0.938)T(0.062)YGLPAGGIQPHPQTK;IS(0.891)T(0.095)Y(0.013)GLPAGGIQPHPQT(0.001)K 105.38 0.0011482 11618500.0 87280.0 91696.0 81535.0 107708.0 88447.0 96496.0 104349.0 84847.0 80007.0 87128.0 True False 82429.32700952285 98728.78835088876 76289.1268685958 93037.98459333624 77335.49713378775 109787.44809652693 109201.43526362094 85093.8907228229 96010.63558235863 84612.38825426946 0.9741992716458224 1.1668360908830273 0.9016307002154182 1.099578755698834 0.9139973321800838 1.2975339706356435 1.2906081191735033 1.0056906852351983 1.1347113296676627 1.0 16.368581285974642 -6.751580912835371 24.99990821511542 1.1551207082397332 1.0187095783974462 0.24034310272310655 0.11856700059800099 306.46868680357125 777167.7595109637 0.03927449795482608 0.03882433139552403 1.7718179093114383e-07 6.751580912835371 -0.13641112984228698 IS(ph)VQPS(ph)S(ph)S(ph)LS(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 ISVQPSSSLSAR 12 0 C9J159;F5H6W4;Q9H992 C9J159 MARCH7 E3 ubiquitin-protein ligase MARCH7 5 IS(1)VQPS(1)S(1)S(1)LS(1)AR 75.911 0.017679 6291400.0 0.0 1027.0 2735.3 2149.3 6525.8 2302.9 1531.6 3365.6 5604.6 0.0 True False 0.0 1105.767597674522 2559.313775969461 1856.5616322506962 5705.970662607792 2620.1035713552046 1602.8224348078236 3375.393338794924 6725.676605608107 0.0 0.0 IS(ph)YTPPESPVPSYASSTPLHVPVPR ddPTM_A459_Selumetinib_30min_R2 1 ISYTPPESPVPSYASSTPLHVPVPR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 1 IS(0.368)Y(0.312)T(0.312)PPES(0.008)PVPSYASSTPLHVPVPR 83.602 0.00095563 0.0 18974.0 18696.0 19088.0 14810.0 15952.0 14295.0 15048.0 15114.0 11012.0 13526.0 True False 17919.50103894005 20129.92308288497 17859.89886144301 12792.852451325001 13947.9671473106 16264.006492910088 15747.761817046323 15157.979237742611 13214.707700987843 13135.469235231487 1.3642071492107037 1.5324860286599589 1.3596696502885353 0.973916669608762 1.0618552636018406 1.2381747619100922 1.1988731833658623 1.1539731825557034 1.0060324046547058 1.0 13.681180117992051 -5.610694701189428 5.630599872082876 1.1073374854406888 1.4479511823374438 0.7313861422252789 0.09171874931345116 0.10542329810845512 5.25719002873659 0.026064311683926613 0.045926810677205276 2.450785481002504e-06 5.610694701189428 0.340613696896755 ISAAASDS(ph)GVESFDEGSSH ddPTM_A459_Selumetinib_30min_R2 1 ISAAASDSGVESFDEGSSH 19 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 ISAAASDS(1)GVESFDEGSSH 218.2 4.0404000000000005e-19 1760300.0 3500.0 3325.3 3816.2 3715.5 4001.5 5160.8 3119.7 3075.8 2873.3 4118.2 True False 3305.484011610107 3580.339817475257 3570.669846764399 3209.442490404999 3498.795796136117 5871.653354922023 3264.772231568273 3084.7500687738984 3448.0402867098055 3999.2968656314 0.8265162909051125 0.8952423232802451 0.8928244055722705 0.8025016892308892 0.8748527337901771 1.4681714191764605 0.8163365564643669 0.7713231031392527 0.8621616255450035 1.0 11.965530660253265 -6.554361353127445 24.99999258191052 0.9824810078050126 0.8572912408283299 0.10701700920365598 0.18152750949097188 526.5200327816085 418100.4117489151 0.06378258760728067 0.06378310070241341 2.7902212817705875e-07 6.554361353127445 -0.12518976697668271 ISAPELLLHS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 ISAPELLLHSPAR 13 0 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 ISAPELLLHS(1)PAR;ISAPELLLHS(1)PAR 120.9 0.0019487000000000005 22244000.0 8414.0 8994.1 8843.9 9953.5 10169.8 8610.4 8305.3 7571.0 4272.3 7489.2 True False 8610.029829206012 7941.066590756346 7642.946956065365 8215.308075335397 9249.94338562402 8523.787193617687 7678.8245343646095 7370.192485926096 7249.781063553831 8450.51177098559 1.0188767334504072 0.9397142807399668 0.9044359872152409 0.9721669288175241 1.094601562166121 1.0086711224855855 0.9086815973358525 0.8721593065204979 0.8579102970361621 1.0 13.04482299967887 -7.3228526720086125 6.191028691018346 0.8980587601686374 0.9874874748665512 0.2975019941890533 0.05921871500973065 0.2969111597340394 23.304787585576737 0.026821899360423566 0.018028074850348928 4.754965037547252e-08 7.3228526720086125 0.0894287146979138 ISAPELLLHS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 ISAPELLLHSPAR 13 0 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 ISAPELLLHS(1)PAR;ISAPELLLHS(1)PAR 137.52 0.00068567 13828900.0 63552.0 57028.0 63126.0 70052.0 79193.0 60020.0 54636.0 53094.0 49711.0 67043.0 True False 60020.03425881301 61401.86422607856 59064.54188639209 60510.79675355963 69244.0673455973 68287.21019268717 57176.682259180125 53248.4947498151 59654.58904139185 65107.29439136652 0.9218634381890687 0.9430873268513624 0.9071877803944542 0.9294011879809215 1.0635377801043953 1.0488411602885208 0.8781916495482873 0.817857587964461 0.9162504693068966 1.0 15.990531566453667 -7.3128033561253085 24.888101846131228 0.8878963343208808 0.9674987406018576 0.18441001868124718 0.06479060487846616 514.0189278790535 249062.73057916414 0.028822070235673212 0.01943185642902808 4.866274955161759e-08 7.3128033561253085 0.07960240628097681 ISAS(ph)SATR ddPTM_A459_Selumetinib_30min_R1 1 ISASSATR 8 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30;P49023-2;P49023-3;A0A1B0GU60;P49023-4 A0A1B0GTU4 PXN Paxillin 1 IS(0.165)AS(0.647)S(0.188)ATR 126.24 0.0048856 51716000.0 2719.4 2367.6 3093.4 3375.8 3002.5 2519.0 2289.1 2375.9 1433.9 1787.9 True False 2782.7567289687213 2090.400291332622 2673.333270829904 2786.279901614228 2730.92440513443 2493.661147069004 2116.431344035017 2312.883413989145 2433.2235720875988 2017.3943806207774 1.3793816200243565 1.0361882195237304 1.3251416265010543 1.3811280175950797 1.3536889124743623 1.2360801492376883 1.0490915233856082 1.1464706337079427 1.2061219142183124 1.0 10.978277428775629 -7.0821486640920215 5.243464241581534 1.1139619432832188 1.288011992016661 0.4256314341448769 0.10631681316281746 0.25462743982922165 11.926349793376898 0.04231245016940738 0.03287300398861514 8.276587979069169e-08 7.0821486640920215 0.1740500487334422 ISCMSKPPAPNPT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 ISCMSKPPAPNPTPPR 16 1 P46734-3;P46734;J3QR49 P46734-3 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1 ISCMSKPPAPNPT(1)PPR 83.229 0.02605 6847700.0 25239.0 23375.0 30356.0 25922.0 23464.0 20756.0 25364.0 23359.0 21609.0 27706.0 True False 23836.31741972215 25167.787337528694 28402.92800911378 22391.378882055815 20516.24254917853 23614.95059579166 26543.476257812537 23426.97082270936 25931.403805906873 26906.055791166913 0.8859090163467014 0.9353948989353957 1.0556332830632977 0.832205918840277 0.7625139376955384 0.8776816185575701 0.9865242406330916 0.8706950957263787 0.9637757390817567 1.0 14.71564329867425 -9.523838627238693 8.809995263031967 0.9999999999921099 0.9068132423502981 0.11042450505325663 0.07844844524035913 26633587.709297482 0.0 0.08085433005146074 0.020213582512865192 2.9933766924811126e-10 9.523838627238693 -0.09318675764181172 ISDEDWDIIHR ddPTM_A459_Selumetinib_30min_R1 1 ISDEDWDIIHR 11 0 E7ER27;A0A2R8YD50;P51659-3;P51659;P51659-2;A0A2R8YDT8;A0A2R8YF45 E7ER27 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 184.24 3.6947e-05 6358800.0 3833.1 4286.0 3516.2 4448.1 3682.3 3481.2 3534.6 3432.7 2381.4 3069.6 False True 3922.4037720857564 3784.1931274926587 3038.719353104062 3671.322836178165 3349.236615162867 3446.182288676704 3267.9822762772123 3341.6536450189546 4041.061869425623 3463.61306043601 1.1324601517676436 1.092556547588573 0.8773264507558876 1.059969105127467 0.9669777070136278 0.9949674598590664 0.9435182912336717 0.9647883833185157 1.166718625583691 1.0 11.7580620522063 -5.0215750775332015 23.97106838940555 0.9940967213087822 1.1224843318949338 0.2976856681151113 0.07215296940433409 436.98978977629866 485524.3150598749 0.017583866402194403 0.04764753900211466 9.515353396876693e-06 5.0215750775332015 0.12838761058615156 ISDEDWDIIHR ddPTM_A459_Selumetinib_30min_R2 2 ISDEDWDIIHR 11 0 E7ER27;A0A2R8YD50;P51659-3;P51659;P51659-2;A0A2R8YDT8;A0A2R8YF45 E7ER27 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 ; 172.61 0.0003339 2671300.0 46427.0 38323.0 47615.0 48287.0 53134.0 38178.0 39096.0 46827.0 34251.0 41064.0 False True 43846.7732020064 41262.25087213314 44551.50273929217 41710.22730027887 46458.83189601313 43436.67295462198 40914.04146725431 46963.25881737283 41102.15705290002 39878.3756229148 1.09951251817818 1.0347023976679517 1.1171844901749737 1.0459359652631253 1.1650131473589183 1.0892287430499683 1.0259706125979815 1.1776622814693318 1.0306878455019621 1.0 15.283319024779702 -8.510529831591356 24.483803078027066 0.9999999802201389 1.0922505014997281 0.3109330640043093 0.04808637092349505 518.5344517718095 1028082.2299673645 0.04388342731702102 0.01133065225821887 3.086527625506117e-09 8.510529831591356 0.09225052127958921 ISDYFEFAGGSAPGT(ph)SPGR ddPTM_A459_Selumetinib_30min_R2 1 ISDYFEFAGGSAPGTSPGR 19 0 Q86UE8-2;Q86UE8 Q86UE8-2 TLK2 Serine/threonine-protein kinase tousled-like 2 1 ISDYFEFAGGS(0.009)APGT(0.496)S(0.496)PGR 93.495 0.0047183 3165700.0 8404.7 8600.0 10240.0 9538.2 12086.0 9911.5 9537.3 9599.1 7962.6 8442.6 True False 7937.60042067985 9259.592346641572 9581.169548469006 8239.080705687247 10567.64862978911 11276.719157361202 9980.803347801424 9627.031791783453 9555.342493632928 8198.840201490859 0.9681369834768208 1.1293783168206923 1.1686005963046808 1.0049080727526647 1.2889199411238081 1.375404188913289 1.2173433196059287 1.1741943439796394 1.1654505099264414 1.0 13.001204126844152 -3.6412143420457794 0.7353405547255568 1.2010484536432673 4.5738547269277367e-10 0.24029651511819106 0.1077614876080972 17.964009193668126 2.060097336524868 0.04295219014516979 26.24510939158731 0.0002284471045435043 3.6412143420457794 -1.2010484531858818 ISDYFEFAGGSAPGTS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 ISDYFEFAGGSAPGTSPGR 19 0 Q86UE8-2;Q86UE8 Q86UE8-2 TLK2 Serine/threonine-protein kinase tousled-like 2 1 ISDYFEFAGGS(0.001)APGT(0.175)S(0.824)PGR 138.98 0.00013897 22605000.0 1414.4 1892.4 1920.6 2305.9 1654.9 1499.1 1486.9 1405.1 939.89 1253.8 True False 1447.3527680566897 1670.836928247109 1659.793069100639 1903.2178521038713 1505.214587196326 1484.0204150738953 1374.7419358899426 1367.8321835919646 1594.9246831504379 1414.737443046217 1.0230539773798912 1.1810226246995044 1.1732163287675255 1.3452799043798944 1.0639533113333688 1.048972318056768 0.9717293782299591 0.9668452547963557 1.1273644385323125 1.0 10.466318617039228 -6.5035610756414926 23.491059311280328 1.0220129758212317 1.1831994429071397 0.4446492840271796 0.08360817710673492 324.6922967401847 394839.3551708357 0.02657079177898606 0.0296315765440344 3.1364540137746705e-07 6.5035610756414926 0.161186467085908 ISDYFEFAGGSAPGTS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 ISDYFEFAGGSAPGTSPGR 19 0 Q86UE8-2;Q86UE8 Q86UE8-2 TLK2 Serine/threonine-protein kinase tousled-like 2 1 ISDYFEFAGGS(0.001)APGT(0.242)S(0.756)PGR 109.1 0.00071117 3288500.0 17784.0 20583.0 24775.0 21788.0 24819.0 18200.0 19616.0 17500.0 16986.0 24298.0 True False 16795.636474992618 22161.64991522366 23181.003472980443 18820.43681360359 21701.01533532484 20706.884796849503 20528.1828683666 17550.92210271905 20383.674628494337 23596.453606214283 0.7117864724625134 0.9391940960732863 0.9823935350554361 0.7975959916555894 0.9196727481798253 0.8775422418306201 0.8699689881771202 0.7437949106935671 0.8638448373922665 1.0 14.526282427730353 -8.59847429422936 20.457486641436773 1.0000000006528305 0.8599954721520544 0.22262613718409863 0.08036455614214673 27622.40316722023 7475094.690661954 0.07768724794187058 0.020058761114152775 2.5207263763228052e-09 8.59847429422936 -0.14000452850077605 ISDYFEYQGGNGS(ph)SPVR ddPTM_A459_Selumetinib_30min_R1 1 ISDYFEYQGGNGSSPVR 17 0 B3KRP1;Q9UKI8;Q9UKI8-2;Q9UKI8-5;C9JWT6;Q9UKI8-4 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 ISDYFEYQGGNGS(0.674)S(0.326)PVR 195.77 9.3466e-08 16490000.0 3073.0 3542.3 4218.0 4370.8 3183.8 3137.1 3619.7 3105.2 1742.1 2700.8 True False 3144.5949209828927 3127.5658692294073 3645.2187678155246 3607.5218300774545 2895.8258521455436 3105.5436222588983 3346.6631147628123 3022.84000888888 2956.2164620502153 3047.4739880197963 1.0318693230343876 1.0262813994555713 1.1961443418862894 1.1837744454125987 0.9502380868645933 1.0190550057087886 1.098176105167488 0.9919165908461378 0.970054698964345 1.0 11.573398191310691 -6.266476610558909 24.996759617656537 1.0098734596190593 1.1097595904750297 0.39850014523686184 0.06278498049689443 507.3637944092571 2517741.108897874 0.0211174126123577 0.02464952092713289 5.414064051774679e-07 6.266476610558909 0.09988613085597042 ISDYFEYQGGNGS(ph)SPVR ddPTM_A459_Selumetinib_30min_R2 4 ISDYFEYQGGNGSSPVR 17 0 B3KRP1;Q9UKI8;Q9UKI8-2;Q9UKI8-5;C9JWT6;Q9UKI8-4 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 ISDYFEYQGGNGS(0.5)S(0.5)PVR;ISDYFEYQGGNGS(0.5)S(0.5)PVR;ISDYFEYQGGNGS(0.781)S(0.219)PVR;ISDYFEYQGGNGS(0.85)S(0.15)PVR 130.02 0.00089358 66441900.0 71008.0 71144.9 87057.0 89844.0 98828.0 67246.0 63949.6 73391.0 67045.0 84270.0 True False 67061.65962754595 76601.48506309073 81455.84740049463 77607.09221045532 86412.34310647016 76508.52610159019 66923.38311372837 73604.55565946597 80455.87339381866 81836.90614024515 0.8194549719734194 0.9360261607619624 0.9953436810148042 0.948314102655089 1.0559092123837626 0.934890255632054 0.8177653123767992 0.8994054043701105 0.9831245728661859 1.0 16.320463984304048 -5.650500734241504 0.00576861885168519 1.8613742853136779 1.0193273081980398e-07 0.06452555515190161 0.07053225935938663 73699.59820805615 90.75025085150767 14198.64674147781 15089.628768696677 2.2361414181789164e-06 5.650500734241504 -1.861374183380947 ISDYFEYQGGNGSS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 3 ISDYFEYQGGNGSSPVR 17 0 B3KRP1;Q9UKI8;Q9UKI8-2;Q9UKI8-5;C9JWT6;Q9UKI8-4 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 ISDYFEYQGGNGS(0.094)S(0.906)PVR;ISDYFEYQGGNGS(0.008)S(0.992)PVR;ISDYFEYQGGNGS(0.007)S(0.993)PVR 318.94 1.658199999999999e-118 202909000.0 8567.4 8891.0 10410.0 10422.8 9579.7 8069.1 8268.699999999999 8296.5 4531.4 6748.599999999999 True False 8767.003750741565 7850.03758668624 8996.379178036892 8602.65364018745 8713.217826433407 7987.9321801566075 7644.985301831437 8076.449869169977 7689.454839638562 7614.848546930685 1.151303758270449 1.030885583384367 1.1814258842564977 1.1297209113443127 1.1442404629236442 1.0489942289628729 1.0039576302424162 1.060618582154907 1.0097974755831418 1.0 12.894599627643215 -6.878519992705181 4.622680602779354 1.0240359401504275 1.125045236791961 0.6309051620200845 0.039689063747450154 0.14983097362146097 5.386813335426694 0.014121249598616041 0.012444308052153583 1.3227568136241665e-07 6.878519992705181 0.10100929664153346 ISDYFEYQGGNGSS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 ISDYFEYQGGNGSSPVR 17 0 B3KRP1;Q9UKI8;Q9UKI8-2;Q9UKI8-5;C9JWT6;Q9UKI8-4 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 ISDYFEYQGGNGS(0.003)S(0.997)PVR 308.39 5.341799999999996e-103 39410000.0 47844.0 48652.0 53812.0 54077.0 50937.0 43114.0 38283.0 42255.0 34565.0 40348.0 True False 45185.02201470684 52383.45195916344 50349.7945060756 46711.61931197176 44537.83867744234 49052.56215007523 40063.23535632536 42377.95505430819 41478.96582679307 39183.04840330623 1.1531778117318245 1.3368906732316255 1.2849892123714175 1.1921384684309113 1.1366608901640303 1.2518822334899349 1.0224634628719917 1.081537980866552 1.058594660626076 1.0 15.257942021801485 -7.1212413726822295 0.6767589081399579 1.0135551646495315 1.2636002232584926 0.6477158711428436 0.06427409283678266 0.45596844175194867 0.42831411207125913 0.053762549247159425 0.0402399614858294 7.564123784402391e-08 7.1212413726822295 0.2500450586089611 ISEGLPT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 ISEGLPTPTK 10 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 ISEGLPT(1)PTK;IS(0.002)EGLPT(0.997)PT(0.002)K 142.89 0.0026879 65796000.0 20411.6 20346.4 19771.8 18260.0 19682.9 16940.4 18798.699999999997 19584.4 9438.900000000001 17981.1 True False 20887.150565940265 17964.234029215266 17086.898158723307 15071.233782651754 17902.58517029824 16769.99495665253 17380.698924079792 19064.958092903315 16017.123910019958 20289.14933574599 1.0294739429583033 0.8854109027412684 0.8421692736333273 0.742822359540665 0.8823723890068158 0.8265499296762867 0.8566499578894612 0.9396627614798092 0.7894428516921871 1.0 14.308420757959555 -10.02320235610014 12.803493536630029 0.9999994930827597 0.8635088435241766 0.22285451903033404 0.07489909774290034 0.0 0.0 0.07286022492142645 0.017671200191605976 9.479766581086343e-11 10.02320235610014 -0.13649064955858314 ISEGLPT(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 ISEGLPTPTK 10 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 ISEGLPT(0.991)PT(0.009)K;ISEGLPT(0.976)PT(0.024)K 148.78 0.0018084 55975000.0 671770.0 614870.0 645080.0 754030.0 753930.0 591760.0 745550.0 768910.0 710870.0 604860.0 True False 634435.7127083782 662028.5518813374 603576.2551099979 651329.8132256983 659214.5731802841 673269.5685375642 780219.5522792976 771147.4008000961 853063.8633673476 587396.1201849866 1.0800815512853192 1.1270563919844194 1.0275455257006392 1.1088425524849863 1.1222657939461362 1.1461934211031797 1.3282681404732224 1.3128234496292575 1.4522803846554098 1.0 19.163974210973997 -7.113573053813305 3.181623843716071 1.299632230648227 1.093727217885204 0.3637810614368562 0.1101874914413238 0.24290423681412707 4.646008918081795 0.04283234989705624 0.03246957278525797 7.698869287655514e-08 7.113573053813305 -0.2059050127630231 ISEGLPTPTKMT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 ISEGLPTPTKMTPR 14 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 ISEGLPTPT(0.064)KMT(0.936)PR;ISEGLPTPT(0.016)KMT(0.983)PR 132.25 0.0011393 100684000.0 6954.799999999999 7911.1 8997.3 10444.400000000001 8891.6 7495.8 7889.099999999999 7601.2 4339.2 6302.299999999999 True False 7116.833308314945 6984.864734229386 7775.5160786312435 8620.481605669669 8087.356349939479 7420.399057641857 7294.018835449154 7399.591483822674 7363.30547737116 7111.26159460055 1.000783505660743 0.9822258176429434 1.093408810123797 1.2122295729094037 1.1372604203001138 1.0434715358068152 1.0256996931440925 1.0405455326578124 1.0354429209807134 1.0 12.795889812835114 -6.978601919354011 23.395627656248628 1.0296272134126028 1.0873160682132035 0.17588971945898235 0.06141092569877308 242.55860076072116 265199.6117800868 0.02503123037856365 0.02207272372406267 1.0505048955632944e-07 6.978601919354011 0.05768885480060071 ISEGLPTPTKMT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 ISEGLPTPTKMTPR 14 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 ISEGLPT(0.001)PT(0.158)KMT(0.84)PR;ISEGLPTPT(0.006)KMT(0.994)PR;ISEGLPTPT(0.001)KMT(0.999)PR 178.02 9.8348e-05 97423200.0 320513.0 305230.0 388926.0 383796.0 430270.0 245461.0 206693.0 277276.0 184200.0 363199.0 True False 302700.1705751969 328640.1595308605 363902.9245906105 331522.3227149722 376215.6359373958 279271.0246768942 216304.63405440951 278082.8272544871 221045.1469780202 352712.50116566854 0.858206526774108 0.9317508124740345 1.0317267558931398 0.939922235870105 1.0666353891456994 0.7917809086832479 0.6132604694745751 0.788412166666789 0.6267006308182869 1.0 18.428133184451326 -6.9129873808457445 6.180733166151315 0.7344754764959643 0.9649901754276374 0.4396364406267461 0.11307702094002423 0.17248106088865436 9.881877241964764 0.037916084488577244 0.03338115685668685 1.2218351621180964e-07 6.9129873808457445 0.2305146989316731 ISEQFTAMFR ddPTM_A459_Selumetinib_30min_R1 1 ISEQFTAMFR 10 0 P04350;P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;Q9BVA1;Q13885 P04350;P68371;P07437;A0A0B4J269;Q9BVA1 TUBB4A;TUBB4B;TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 0 164.66 0.005148300000000001 23190000.0 1098.9 778.51 1305.4 949.73 1333.2 1044.3 887.4 773.64 826.28 733.26 False True 1124.5022319128225 687.3616872805204 1128.1338500489296 783.87748414008 1212.6122953955778 1033.7952901485346 820.4627035501617 753.1205540631178 1402.1368108965341 827.3810635572413 1.3591104286072717 0.8307679708371355 1.3634997218798217 0.9474201412948442 1.465603152895564 1.24947903170981 0.9916382422661031 0.9102463027436862 1.6946687235844975 1.0 9.69240812846369 ISES(ph)PEPGQR ddPTM_A459_Selumetinib_30min_R1 1 ISESPEPGQR 10 0 O14867;H7C4B6 O14867 BACH1 Transcription regulator protein BACH1 1 IS(0.055)ES(0.945)PEPGQR 93.839 0.024656 8345100.0 2010.2 2056.2 2412.0 2612.7 2306.9 2021.8 2273.4 1976.3 1091.2 1750.5 True False 2057.033748831701 1815.4591480985544 2084.463648167624 2156.440991453135 2098.2413023162762 2001.4625276475235 2101.9156076751588 1923.8821040728772 1851.686701905283 1975.1937263139284 1.0414339218616804 0.9191296650615289 1.055321116302659 1.0917617663141566 1.0622964595133546 1.0132993543790854 1.0641566848218562 0.9740219799417812 0.9374709311986668 1.0 10.947778443919374 -7.858214666417034 6.775452704067228 0.964961627122843 1.033885697777196 0.29288028154087886 0.04603618571121913 0.2922386859709148 17.37530185657135 0.02699185433169345 0.012859623581212613 1.3860705419125128e-08 7.858214666417034 0.06892407065435302 ISES(ph)PEPGQR ddPTM_A459_Selumetinib_30min_R2 1 ISESPEPGQR 10 0 O14867;H7C4B6 O14867 BACH1 Transcription regulator protein BACH1 1 IS(0.001)ES(0.999)PEPGQR 107.34 0.011348 9974900.0 46108.0 39865.0 42344.0 44780.0 50387.0 33320.0 32458.0 36989.0 34858.0 44816.0 True False 43545.501944948264 42922.51731382165 39619.633140661324 38680.886750191305 44056.9345945047 37909.52755115523 33967.36131430686 37096.631866141426 41830.57401389705 43522.045634048045 1.0005389523989163 0.986224721023743 0.91033480994437 0.8887653644646377 1.0122900693812564 0.8710419512427043 0.7804633449429043 0.8523641599493221 0.961135291425095 1.0 15.409458747643638 -6.7897558523792645 24.944299503528367 0.8767400627328792 0.9544326019474141 0.17660659199062745 0.0670464432673031 317.49165678060575 279679.79239356535 0.024045756080880668 0.02121034130495395 1.6227220877543195e-07 6.7897558523792645 0.0776925392145349 ISFPGSS(ph)ESPLSSK ddPTM_A459_Selumetinib_30min_R2 1 ISFPGSSESPLSSK 14 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ISFPGS(0.058)S(0.85)ES(0.089)PLS(0.002)S(0.001)K 113.43 0.0032969 8102400.0 42869.0 31870.0 41396.0 42094.0 46295.0 27269.0 32020.0 33848.0 29782.0 31906.0 True False 40486.5125982039 34314.32652179849 38732.62642855692 36360.72458379974 40479.00821744888 31025.057226664227 33508.99344642629 33946.49207616194 35739.23217860699 30984.790878256354 1.3066576036378998 1.1074570958579115 1.2500528591831688 1.1735023394757187 1.3064154080141013 1.0012995520468764 1.0814658578167555 1.0955856442453504 1.1534443565887376 1.0 14.919272610892033 -6.764821603383759 24.999998746813656 1.073277359678564 1.2201815673084746 0.5754155312162821 0.0694509296208174 70.12796819124269 518353.13628159603 0.02310385010444655 0.02119598245069969 1.7186142031634012e-07 6.764821603383759 0.14690420762991052 ISFPGSSES(ph)PLSSK ddPTM_A459_Selumetinib_30min_R2 1 ISFPGSSESPLSSK 14 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 ISFPGS(0.008)S(0.03)ES(0.911)PLS(0.046)S(0.005)K 111.43 0.0039332 11249000.0 67952.0 53083.0 62197.0 68163.0 71687.0 50787.0 52615.0 51624.0 50883.0 57088.0 True False 64175.4998734086 57154.29541125284 58195.312734973326 58879.08181226642 62681.03817008869 57782.44825151623 55061.70175464461 51774.21729318675 61061.02178980794 55439.72110756284 1.1575725597337838 1.0309268205076902 1.04970428372221 1.0620378428316877 1.130616044198282 1.042257195692022 0.9931814348022278 0.9338830762286059 1.101394822519738 1.0 15.758632379489438 -7.010702394931747 6.039319947329987 1.0033956053363768 1.0805147031414475 0.3389843231429863 0.05173585102812099 0.19024587252005037 27.68640690604416 0.01891897761652156 0.015545709520087951 9.756579890568312e-08 7.010702394931747 0.07711909780507065 ISFPPSCPDAVVATPPGAS(ph)PPVKDR ddPTM_A459_Selumetinib_30min_R1 2 ISFPPSCPDAVVATPPGASPPVKDR 25 1 Q8N4X5-2;Q8N4X5;Q8N4X5-4;Q8N4X5-3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 ISFPPSCPDAVVAT(0.003)PPGAS(0.997)PPVKDR;ISFPPSCPDAVVAT(0.002)PPGAS(0.998)PPVKDR 131.31 3.1657000000000003e-08 96315000.0 2638.6000000000004 2822.8 3879.6 3680.6000000000004 3154.6 2839.12 2778.7 2989.6 1867.6599999999999 2691.8199999999997 True False 2700.074246178152 2492.3052637158817 3352.7716291173792 3037.8523034188443 2869.266986989865 2810.561030514707 2569.100421855796 2910.306096410599 3169.282611510651 3037.341317547189 0.8889597723441244 0.8205548876965028 1.1038507953478591 1.0001682345901342 0.9446639962435789 0.92533592266291 0.8458385651338249 0.9581755200172308 1.0434397323742368 1.0 11.568593323382894 -5.214084384295438 24.99998098963516 0.9692358965190422 0.8547572649373558 0.3403629203649692 0.06763910752843685 521.5011126833024 275312.7295942047 0.01839169737700895 0.048659622745642186 6.108233291673512e-06 5.214084384295438 -0.11447863158168636 ISFPPSCPDAVVATPPGAS(ph)PPVKDR ddPTM_A459_Selumetinib_30min_R2 2 ISFPPSCPDAVVATPPGASPPVKDR 25 1 Q8N4X5-2;Q8N4X5;Q8N4X5-4;Q8N4X5-3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 ISFPPSCPDAVVATPPGAS(1)PPVKDR;ISFPPSCPDAVVAT(0.009)PPGAS(0.991)PPVKDR 143.04 5.564e-09 34219000.0 199088.0 192427.0 207611.0 226457.0 216956.0 149854.0 161257.0 172059.0 138561.0 212867.0 True False 188023.4859724097 207185.5321496745 194253.53428976523 195613.16593988542 189700.04766875133 170495.0282608289 168755.77002468344 172559.66320409926 166277.0717178147 206720.97661511265 0.9095520399097415 1.0022472588034779 0.9396895151643939 0.9462666495819216 0.9176623039177487 0.824759204665854 0.81634565000573 0.8347467491186572 0.8043550995185205 1.0 17.65732526534392 -6.603634779237863 3.708360503651397 0.8434102452087782 0.9510676691476848 0.37113574257841997 0.05643020324981849 0.20699219964138282 5.610640549320895 0.0181830287715771 0.018341404087692918 2.4909512078363757e-07 6.603634779237863 0.10765742393890665 ISGPECTT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ISGPECTTPK 10 0 Q5VWG9 Q5VWG9 TAF3 Transcription initiation factor TFIID subunit 3 1 ISGPECT(0.191)T(0.809)PK 100.88 0.039652 8336700.0 3278.6 3974.9 4212.1 3944.6 3264.6 3357.4 3125.2 2944.9 1707.0 2430.0 True False 3354.985000954937 3509.5168601191244 3640.1199554091436 3255.7496593126043 2969.317506411942 3323.627604275298 2889.463647887045 2866.7916856166653 2896.6543256527843 2741.9141702044253 1.2235922763055722 1.2799513924454717 1.3275834798059167 1.1874002821429928 1.0829359790611397 1.2121559603842387 1.0538125807459608 1.045543918467342 1.056435083610521 1.0 11.420967695984013 -6.678388213879185 0.5895615233545207 1.0146426648099118 1.293312942523561 0.7620014661743825 0.05229860403885636 0.43621773776619477 0.3313404727615136 0.04402419630917809 0.05498900794569471 2.0970644890537078e-07 6.678388213879185 0.27867027771364916 ISHEGS(ph)PVKPVAIR ddPTM_A459_Selumetinib_30min_R1 1 ISHEGSPVKPVAIR 14 1 Q96II8-3;Q96II8;Q96II8-2 Q96II8-3 LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 1 IS(0.001)HEGS(0.999)PVKPVAIR 79.471 0.01978 21637000.0 2482.3 2454.4 2146.1 3160.3 2362.8 2121.9 2506.2 2080.6 1374.1 2684.9 True False 2540.132760285011 2167.037706980397 1854.6714076834742 2608.4129311782244 2149.085157186221 2100.5556125310504 2317.155316246803 2025.4157292587288 2331.747339706791 3029.5330681406836 0.8384568523108967 0.7153041931674223 0.6121971161786137 0.8609950353765529 0.7093783460515847 0.693359526133255 0.7648555946177249 0.6685570626571137 0.7696721861952989 1.0 11.564879737704151 -8.560366239187436 20.58446612764005 1.0000000017741777 0.7307384389232112 0.5604619076673871 0.07052959659716349 1085.3795467733387 595984.2874928653 0.0657684597520666 0.016981343294648114 2.7519070498879184e-09 8.560366239187436 -0.2692615628509665 ISHEGS(ph)PVKPVAIR ddPTM_A459_Selumetinib_30min_R2 2 ISHEGSPVKPVAIR 14 1 Q96II8-3;Q96II8;Q96II8-2 Q96II8-3 LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 1 ISHEGS(1)PVKPVAIR;IS(0.013)HEGS(0.987)PVKPVAIR 95.751 0.006752500000000001 38800000.0 101089.0 105955.0 120353.0 135933.0 150077.0 112201.0 117383.0 129132.0 101639.0 124322.0 True False 95470.87807132967 114081.40780097777 112609.61901043858 117418.69090249586 131222.9855545971 127655.66929073138 122841.54209000188 129507.75274104658 121969.64003093944 120732.50083265164 0.790763691739167 0.9449105006041993 0.9327200069062409 0.9725524617869957 1.0868903124643001 1.0573430386211913 1.0174687117619936 1.0726834269801004 1.010246944192787 1.0 16.881454572057194 -3.9634499956767235 0.6368317457189688 1.0433858949862223 0.26241854755088845 0.8038908428461649 0.0363337392793087 3.609982653075301 0.5133028182632352 0.016402814983210546 2.6029428046256777 0.00010878023791266324 3.9634499956767235 -0.7809673474353338 ISHSLYSGIEGLDES(ph)PSR ddPTM_A459_Selumetinib_30min_R1 3 ISHSLYSGIEGLDESPSR 18 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 ISHSLYSGIEGLDES(0.894)PS(0.106)R;ISHSLYSGIEGLDES(0.987)PS(0.013)R;ISHSLYSGIEGLDES(0.892)PS(0.108)R 267.29 5.133099999999998e-54 47614000.0 6834.09 7215.889999999999 7022.539999999999 8160.46 8946.39 7226.01 7452.79 6207.99 2509.5699999999997 4997.18 True False 6993.311000175718 6371.050244223749 6068.917640051026 6735.3888518060485 8137.190604113443 7153.322900092135 6890.620050024346 6043.333938806544 4258.556998259203 5638.616729655206 1.2402529442009707 1.1298959567009497 1.0763132042886931 1.1945108480919768 1.4431182316963442 1.268630808416296 1.2220408622179395 1.071775974242549 0.755248530346486 1.0 12.461125567493184 -8.000032149848339 3.661487448897205 0.8793782925991912 1.223244503674675 0.6281568839557015 0.10642970954912037 0.1559772827025634 4.464198704729161 0.07939300786122569 0.030621660951654184 9.999259749784596e-09 8.000032149848339 0.3438662110754839 ISHSLYSGIEGLDES(ph)PSR ddPTM_A459_Selumetinib_30min_R2 4 ISHSLYSGIEGLDESPSR 18 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 ISHSLYSGIEGLDES(0.883)PS(0.117)R;ISHSLYSGIEGLDES(0.851)PS(0.149)R;ISHSLYSGIEGLDES(0.759)PS(0.241)R;ISHSLYSGIEGLDES(0.85)PS(0.15)R 232.87 2.8211e-19 46000200.0 47422.899999999994 49190.0 60285.0 75835.7 82124.0 55630.1 51929.799999999996 56074.200000000004 52001.299999999996 63740.5 True False 44787.32506690998 52962.71482922077 56406.328733345115 65506.74683612073 71806.84892212492 63292.64131523174 54344.63859694658 56237.366638416475 62403.013037720615 61900.14614729209 0.7235415076458469 0.8556153438344943 0.9112471010831804 1.0582648170207336 1.160043285701777 1.0224958300522617 0.8779403923802199 0.9085175098714473 1.0081238401155297 1.0 15.917655195220405 -5.093609141987435 1.7264146736414916 1.000696691078085 0.7143619754887971 0.5792206222749633 0.07551259377050354 0.44062778894520804 1.9934182795665276 0.024820396801847378 0.1706076838484477 8.06103595040182e-06 5.093609141987435 -0.2863347155892879 ISHTPQTPLYT(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 ISHTPQTPLYTPER 14 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 ISHT(0.153)PQT(0.278)PLY(0.14)T(0.428)PER 98.077 0.014435 5802100.0 1032.0 1467.9 1316.4 1485.1 1348.5 1127.3 1298.2 1206.5 689.89 930.49 True False 1056.0435920775615 1296.0375855918035 1137.6401104676047 1225.7551637796344 1226.5284130970122 1115.9603855065056 1200.2757288131843 1174.4997007356799 1170.6929424280015 1049.9274552401293 1.0058252946971782 1.2344067955584477 1.0835416340335766 1.1674665308178758 1.168203009622691 1.0628928502981894 1.1431987256097316 1.1186484312547667 1.1150226966493146 1.0 10.036073932952565 -10.310493579383241 0.5301405659008068 0.9705552837600956 1.129468122046376 0.2699192913796131 0.05995802970539742 19.112170320468387 3.7407386518418546 0.9999408618908997 0.025327676275574716 4.892224977544022e-11 10.310493579383241 0.15891283828628044 ISHTPQTPLYT(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 ISHTPQTPLYTPER 14 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 IS(0.006)HT(0.004)PQT(0.298)PLY(0.005)T(0.687)PER 127.91 0.0015960999999999998 4616000.0 15130.0 14676.0 14607.0 12874.0 15975.0 9180.8 13830.0 12737.0 13108.0 13368.0 True False 14289.135170188836 15801.60200922229 13667.201522899106 11120.538991111269 13968.077681687988 10445.371864995375 14473.122403625104 12774.062561276134 15729.966268121036 12982.031105764781 1.1006856364597388 1.2171902748103456 1.052778368157666 0.8566101021105318 1.075954722946654 0.8046022829476213 1.1148580900563543 0.9839802768307728 1.2116722059875522 1.0 13.66422849763032 -2.0983050038061117 9.215045149565588 1.0378047160979436 1.201187491407635 0.0 0.12865499538086594 0.0 0.0 0.029614285050269498 0.0 0.007974344545676804 2.0983050038061117 0.16338277530969147 ISINQT(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 ISINQTPGK 9 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 ISINQT(1)PGK;ISINQT(1)PGK 125.36 0.011841 47500000.0 174120.0 170593.0 176421.0 180791.0 185124.0 140699.0 150417.0 156917.0 122059.0 166071.0 True False 164443.1074575864 183676.93455704965 165070.26493266085 156166.9539181298 161867.06809044175 160079.0101116442 157411.6885456311 157373.60249099217 146474.21061341054 161276.09872572284 1.0196371858997506 1.1388974312270734 1.0235259051832015 0.9683205084450733 1.00366433321111 0.9925773960088501 0.9760385437729132 0.9758023894081942 0.9082201998357773 1.0 17.29917311996759 -5.521119896346984 4.8785103990290875 0.9767083206548295 1.0806646774033244 0.5640590305226262 0.03669185080418349 0.11905524711802014 7.979951768025366 0.009596274475892678 0.018627407856994318 3.012174333777479e-06 5.521119896346984 0.1039563567484949 ISKPGAVST(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 ISKPGAVSTPVK 12 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 ISKPGAVS(0.135)T(0.865)PVK 151.99 0.0052611 71946000.0 6961.5 8797.0 5770.7 5910.5 6482.9 5219.9 7228.5 6276.9 3263.9 6269.1 True False 7123.689405279014 7767.043150385657 4987.070636186115 4878.342128826025 5896.522839648954 5167.39254528999 6683.248425301261 6110.416221755318 5538.599914175817 7073.800051205167 1.0070526949747962 1.0980015117987936 0.7050058808682986 0.6896352870470094 0.833572167288551 0.7304973999667433 0.9447889927511639 0.863809575832481 0.7829737728071919 1.0 12.78826972490369 -5.252508659879487 24.999329994585526 0.8111840225018654 1.052527126832149 0.4798354209738187 0.09708879681694083 526.0600498840263 1472566.2644191387 0.02489257889432375 0.06381064899988204 5.591023788967991e-06 5.252508659879487 0.2413431043302836 ISKPGAVST(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 ISKPGAVSTPVK 12 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 ISKPGAVS(0.123)T(0.877)PVK;ISKPGAVS(0.077)T(0.923)PVK 169.79 0.0034515 287549000.0 308335.0 261852.0 303560.0 307479.0 316530.0 291652.0 349890.0 314423.0 248843.0 288897.0 True False 291198.97506280063 281935.2064131153 284029.28009113733 265599.8297691401 276764.6715858964 331824.4156467448 366160.57829388184 315337.9188744705 298618.5532543511 280555.79296544957 1.037936062502412 1.0049167170390085 1.0123807357138248 0.946691661440221 0.986487103547279 1.1827394905640354 1.305125709305794 1.1239757894191988 1.0643820614002646 1.0 18.097928176573774 -6.757105046295391 24.993987903222823 1.1536106740325514 0.9960680862078675 0.4283420432650218 0.07801837703491904 97.13270500709017 560117.0724425468 0.02692668907086815 0.02603078581466031 1.749423490331338e-07 6.757105046295391 -0.1575425878246839 ISLEQPPNGS(ph)DTPNPEK ddPTM_A459_Selumetinib_30min_R1 3 ISLEQPPNGSDTPNPEK 17 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 ISLEQPPNGS(0.81)DT(0.19)PNPEK;ISLEQPPNGS(0.936)DT(0.064)PNPEK;ISLEQPPNGS(0.793)DT(0.207)PNPEK 196.65 7.015e-08 19406600.0 14296.9 15549.7 10762.099999999999 11535.6 11160.5 10607.9 13921.0 13090.3 6778.9 13727.599999999999 True False 14629.989953075281 13729.133895140589 9300.665931983745 9521.124010030537 10151.034745546305 10501.194157202577 12870.927762138594 12743.102720713036 11503.298188733259 15489.671178147435 0.9444997111181431 0.886341210038688 0.6004430839761767 0.6146756700337691 0.6553421714895544 0.6779481653566335 0.8309361518465724 0.8226838758650208 0.7426431495177197 1.0 13.919018897809192 -11.10294910672052 8.691327512300054 1.0000565609592729 0.747497349899217 0.30736269771911895 0.11105061016920181 0.00013460553079794893 6.503593948080042e-06 0.1189160285930176 0.028834951234004168 7.889525664811975e-12 11.10294910672052 -0.25255921106005585 ISLEQPPNGS(ph)DTPNPEK ddPTM_A459_Selumetinib_30min_R2 6 ISLEQPPNGSDTPNPEK 17 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 ISLEQPPNGS(0.881)DT(0.119)PNPEK;ISLEQPPNGS(0.832)DT(0.168)PNPEK;ISLEQPPNGS(1)DTPNPEK;ISLEQPPNGS(0.864)DT(0.136)PNPEK;ISLEQPPNGS(0.785)DT(0.215)PNPEK;ISLEQPPNGS(0.999)DT(0.001)PNPEK 246.42 2.5013999999999996e-30 29457700.0 171408.0 127076.0 167721.0 191904.0 187210.0 162497.0 173454.0 179917.0 148633.0 143242.0 True False 161881.82956058998 136822.32058625887 156930.0134608177 165766.34414713492 163691.00612136535 184879.4867491019 181519.9546925807 180440.52868313718 178363.75315300832 139106.23127258793 1.163728095281165 0.9835815357411734 1.128130724448302 1.1916529017474762 1.1767338143221056 1.3290525166109792 1.3049016786090644 1.297141954263371 1.2822125329777116 1.0 17.085827521381724 -5.956486977522706 1.4994593530319729 1.259475645868132 1.0718930641644484 0.2738731595500782 0.0992804165122546 0.4190602217884537 1.911383319026549 0.03251482238086538 0.059398433120070954 1.1053836142138319e-06 5.956486977522706 -0.18758258170368358 ISLEQPPNGSDT(ph)PNPEK ddPTM_A459_Selumetinib_30min_R2 2 ISLEQPPNGSDTPNPEK 17 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 ISLEQPPNGS(0.1)DT(0.9)PNPEK;ISLEQPPNGS(0.168)DT(0.832)PNPEK 123.54 0.0031473000000000004 11593000.0 63791.0 45588.0 59206.0 64282.0 69100.0 57652.0 66009.0 71650.0 54335.0 52928.0 True False 60245.75159560584 49084.453011476275 55396.75041861875 55526.68070736483 60419.040238162095 65593.03968725084 69078.54929435207 71858.48963770403 65203.518246746746 51399.83111654091 1.1721001856797588 0.9549535853568296 1.077761331414017 1.0802891663489507 1.1754715711258188 1.276133369748416 1.3439450635105685 1.3980296836924693 1.2685551067066383 1.0 15.649475998740408 -6.493407227670513 2.1031793360214985 1.2891803286362087 1.0598772548737279 0.3680510380135761 0.11093613440907948 0.28110455594863987 2.4870840817480104 0.038527514939109005 0.042430406318282585 3.2106485774557617e-07 6.493407227670513 -0.22930307376248082 ISLPGQMAGTPIT(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 ISLPGQMAGTPITPLK 16 0 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 ISLPGQMAGT(0.243)PIT(0.757)PLK 122.97 0.0022298 0.0 20416.0 10131.0 13252.0 16295.0 14036.0 19744.0 34650.0 37310.0 31267.0 10489.0 True False 19281.360451723416 10908.015123700667 12399.380747686651 14075.592889557107 12272.672196567933 22463.556781812986 36261.293657672424 37418.56592299698 37521.273672973766 10186.155316305114 1.8928987290091175 1.070866758357794 1.2172778013544323 1.3818356830889982 1.2048385102594013 2.2053027942598984 3.5598606669219435 3.6734729405804942 3.6835560138095444 1.0 13.31432199996889 -7.0063465079881535 3.4584204488525834 3.1919374082710266 1.3381381643427144 0.4915757277274839 0.7657390705342452 0.17211782199037406 4.359260263735338 0.28360163429660856 0.23040783456741218 9.854928824522774e-08 7.0063465079881535 -1.8537992439283122 ISLPLPNFS(ph)SLNLR ddPTM_A459_Selumetinib_30min_R1 1 ISLPLPNFSSLNLR 14 0 P08670;B0YJC4 P08670 VIM Vimentin 1 ISLPLPNFS(0.5)S(0.5)LNLR 101.2 0.0084575 100430000.0 4054.8 5531.6 5599.4 5920.4 4849.7 4661.3 5132.0 4629.1 2910.2 3705.0 True False 4149.268950732653 4883.9577004289295 4839.0322353025695 4886.513279672043 4411.04549128408 4614.41155412177 4744.889108203093 4506.321230564062 4938.39684740172 4180.572839756126 0.9925120575042297 1.1682508325136216 1.1575045862817341 1.1688621313334413 1.0551294428687428 1.1037749444860652 1.1349853931692018 1.077919558705007 1.1812727673200407 1.0 12.029484924684064 -6.258471292740073 24.986263445385525 1.0987963119147843 1.1276531569128858 0.038309146234295155 0.06537639059986192 984.3825895988964 8286810.269446368 0.019166118863934666 0.023534957621680307 5.514786544171973e-07 6.258471292740073 0.028856844998101483 ISLS(ph)KSPTK ddPTM_A459_Selumetinib_30min_R1 1 ISLSKSPTK 9 1 A0A0A0MRN4;Q5BKZ1-3;Q5BKZ1 A0A0A0MRN4 ZNF326 DBIRD complex subunit ZNF326 1 IS(0.035)LS(0.67)KS(0.119)PT(0.176)K 119.03 0.033357 129450000.0 4205.0 5444.8 4236.8 5072.9 3997.8 4624.9 4732.7 4001.4 2420.5 3936.9 True False 4302.96831849433 4807.320284781152 3661.4658310765312 4187.013245126732 3636.1996958689188 4578.377705073213 4375.708628681372 3895.269873621013 4107.4117136746145 4442.239463653412 0.9686484381811011 1.0821839579146613 0.8242387338716872 0.9425455965138864 0.8185510316632987 1.0306463085868491 0.9850231317972843 0.8768707552783396 0.9246263618343018 1.0 12.117071449657187 -5.2459454509593835 24.995909017875466 0.9236122309104119 1.0254161911412247 0.23904394970124143 0.07138982098760278 1132.9166054795985 1827694.7448048901 0.017828809920243466 0.0467779726700844 5.676158956491296e-06 5.2459454509593835 0.10180396023081284 ISLSKS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 ISLSKSPTK 9 1 A0A0A0MRN4;Q5BKZ1-3;Q5BKZ1 A0A0A0MRN4 ZNF326 DBIRD complex subunit ZNF326 1 ISLS(0.001)KS(0.551)PT(0.448)K 122.18 0.028610000000000007 47298000.0 107560.0 94308.0 108520.0 97723.0 99934.0 79233.0 73247.0 64529.0 50148.0 88448.0 True False 101582.24579679515 101541.1203519851 101537.94134764223 84412.95881842238 87379.39749870474 90146.6265444382 76653.13063617698 64716.76870664898 60179.00125219205 85894.27642449748 1.1826427793019207 1.1821639878559482 1.1821269771903347 0.9827541756245284 1.017290105185445 1.0495067925006458 0.8924125544448398 0.7534468115990954 0.7006171279071244 1.0 16.39027437995739 -6.687292805142919 0.7374572239645172 0.8011752502045738 1.185548271059271 0.6726506400642196 0.09303779423646662 0.4020495298638733 0.4840907571467983 0.0668493503510801 0.07189347384192664 2.0545049636956074e-07 6.687292805142919 0.38437302085469727 ISMPDIDLNLT(ph)GPK ddPTM_A459_Selumetinib_30min_R1 2 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ISMPDIDLNLT(1)GPK;ISMPDIDLNLT(1)GPK 186.08 0.00019162 25335000.0 8260.0 9102.2 11782.3 11189.4 7938.1 8900.4 8003.900000000001 7912.1 5854.0 7096.700000000001 True False 8452.441928837849 8036.5101925020235 10182.328375541207 9235.381341051681 7220.100256585382 8810.87005691662 7400.159379023142 7702.245405877149 9933.810440756539 8007.63057271183 1.0555484362180536 1.0036065125042868 1.2715781882146573 1.1533226036330577 0.901652516437238 1.1003092583893725 0.9241384591643362 0.9618632298203962 1.240543048352991 1.0 12.967159702491017 -6.220096134043866 24.97400904936171 1.0185914185823646 1.1233822974435843 0.16076795757032936 0.11131319057229179 933.8292107968535 564093.2951616163 0.03313726986395826 0.042779703041339885 6.024262201640039e-07 6.220096134043866 0.10479087886121974 ISMPDLDLHLKS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 ISMPDLDLHLKSPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ISMPDLDLHLKS(1)PK 88.19 0.011606 33747000.0 2760.4 2932.5 4182.7 4145.7 2822.3 3436.0 3348.6 4343.3 2612.2 2783.6 True False 2824.71194919661 2589.1615367177365 3614.712313926504 3421.731319427131 2567.0234633175346 3401.4369596383845 3096.0124060266726 4228.101574973297 4432.712612460578 3140.9021745600953 0.8993313997728153 0.8243368920206393 1.150851606651127 1.0894103443085958 0.8172885752728238 1.0829490288454395 0.9857080017018646 1.3461423947612985 1.4112864285820712 1.0 11.616963294676852 -7.753583194323319 24.685916576433392 1.284035817526236 0.981325486659541 0.42418030148958186 0.14483468724646598 125.46930680785321 394256.9092988253 0.06906853949101806 0.03892280619460717 1.763667880352733e-08 7.753583194323319 -0.3027103308666951 ISMPDLDLHLKS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ISMPDLDLHLKSPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ISMPDLDLHLKS(1)PK 61.419 0.036741 21675000.0 47109.0 50564.0 34341.0 37873.0 31981.0 24430.0 40658.0 32371.0 28943.0 47907.0 True False 44490.870372268735 54442.096211114454 32131.53744765373 32714.63206543089 27963.260866232467 27795.01074654028 42548.677562298566 32465.194250692453 34732.408734988334 46523.80043266556 0.9563034394978307 1.170198816623099 0.6906473062998815 0.7031805605128747 0.6010528075130926 0.5974363763933758 0.9145572194575928 0.6978190506530031 0.7465514083540307 1.0 15.50568133193693 -5.268826281873219 24.937491371336918 0.7274207127482392 1.063251133769851 0.4889964470246839 0.12970815982866546 367.89099196967027 1241968.6734117288 0.03287231551315672 0.07069324138634009 5.384851339107735e-06 5.268826281873219 0.33583042102161176 ISMPDVDLHLK ddPTM_A459_Selumetinib_30min_R1 1 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 113.38 0.01002 8935200.0 8068.7 8815.7 7837.0 8203.3 8054.2 7289.5 7847.0 7265.2 4870.6 6879.5 False True 8256.685011042851 7783.553745692255 6772.778445559567 6770.747650012439 7325.699032084503 7216.1742483364405 7255.094472344058 7072.50329530449 8265.052465450766 7762.550837004665 1.0636561594782237 1.0027056710002422 0.8724939247126373 0.8722323102524205 0.943723163417152 0.9296137828735876 0.9346276275265698 0.9111055687505883 1.0647340853538296 1.0 12.922315096246976 -8.259489246277901 24.983642435120355 1.0323670460151777 0.9381957027154805 0.2952343775670482 0.05613895071074868 215.05100254682134 2755169.4163237745 0.04539448040981103 0.015199980110050637 5.501875437339965e-09 8.259489246277901 -0.09417134329969723 ISMPDVDLHLK ddPTM_A459_Selumetinib_30min_R2 1 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 90.913 0.038157 1633000.0 11802.0 11758.0 12865.0 11159.0 13375.0 12797.0 12027.0 13209.0 11062.0 11830.0 False True 11146.092087149284 12659.80079207111 12037.27990635291 9639.124949651286 11694.7129259829 14559.67059040017 12586.279331048385 13247.436003132336 13274.709098104586 11488.437161968684 0.9702009011327755 1.1019602243184223 1.0477734905667686 0.8390283912211001 1.0179550761436091 1.2673325697074356 1.095560619221037 1.1531103679608086 1.1554843283688032 1.0 13.487894932796284 -6.551521186432596 24.096714562969265 1.1415791584226447 0.9927253858944236 0.3856254908370629 0.08797458120607604 145.01215635565325 121996.52559338674 0.02906718798469428 0.029067794203028848 2.808528359403346e-07 6.551521186432596 -0.14885377252822107 ISMQDVDLSLGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 ISMQDVDLSLGSPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ISMQDVDLSLGS(1)PK;ISMQDVDLS(0.001)LGS(0.999)PK;ISMQDVDLS(0.102)LGS(0.898)PK;ISMQDVDLS(0.029)LGS(0.971)PK 201.75 5.501e-05 362510000.0 12422.3 12128.8 16241.800000000001 15698.2 11345.4 11570.2 12595.9 13403.099999999999 11148.0 11420.5 True False 12711.715420411912 10708.754457473855 14036.252769821283 12956.804061709956 10319.21057319306 11453.814292901057 11645.78112198273 13047.606248595444 18917.341782294818 12886.432420090381 0.986441786680534 0.8310100195596841 1.089227205191275 1.0054609095306986 0.8007810258722239 0.8888274054069594 0.9037242226814123 1.0125072497376224 1.4680045776519222 1.0 13.653565291640337 -8.040979504424456 10.56811847918384 1.2365393633159216 0.9302447529956065 0.4557421812227124 0.1313949831405083 0.6499510658443385 164.6544209028572 0.08330727091392505 0.03185225811551963 9.099562150067363e-09 8.040979504424456 -0.30629461032031513 ISMQDVDLSLGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 ISMQDVDLSLGSPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 ISMQDVDLS(0.358)LGS(0.642)PK;ISMQDVDLS(0.018)LGS(0.982)PK 109.14 0.0046628 13665500.0 47212.0 37884.0 36157.0 42836.0 32715.0 32180.0 45002.0 34229.0 35148.0 39816.0 True False 44588.14604461038 40789.58098374062 33830.69798476503 37001.66290377834 28605.049224189228 36612.502899044855 47094.68216977127 34328.600723084004 42178.58211717407 38666.40862560823 1.1531494035647332 1.0549099963922235 0.8749376833089025 0.9569459440117914 0.739790692773171 0.9468813939652233 1.2179740463038793 0.8878145641989788 1.0908326792274101 1.0 15.238793151246153 -9.389714157862912 14.579651554791361 0.9999999973720656 0.9837930450644845 0.0 0.13517365308059281 0.0 0.0 0.13489102772449316 0.03271587972095327 4.07648493919209e-10 9.389714157862912 -0.01620695230758107 ISMS(ph)EVDLNVAAPK ddPTM_A459_Selumetinib_30min_R1 1 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(0.304)MS(0.696)EVDLNVAAPK 139.21 0.00057249 224400000.0 8152.7 7908.2 8307.2 7993.1 6806.3 7247.3 7195.6 7141.9 3962.2 5184.2 True False 8342.642047607305 6982.30426757756 7179.127868183293 6597.255134069758 6190.671366749865 7174.398742021906 6652.830098789206 6952.47361183933 6723.564012361728 5849.64256838427 1.426179796471159 1.1936292151105128 1.227276330862424 1.127804828576387 1.0582990831283887 1.226467883832353 1.1373054030251262 1.1885296461386483 1.1493974091170571 1.0 12.51413275883274 ISMS(ph)EVDLNVAAPK ddPTM_A459_Selumetinib_30min_R2 1 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 IS(0.403)MS(0.597)EVDLNVAAPK 125.33 0.0013880999999999998 7321900.0 19700.0 22811.0 21598.0 25669.0 21128.0 24075.0 24939.0 20356.0 19415.0 23078.0 True False 18605.15286534832 24560.530351074525 20208.40819412437 22172.837918505156 18473.711753283507 27391.112718909426 26098.712915691016 20415.23258988278 23298.542500424923 22411.678176154965 0.8301543828673829 1.0958809134251197 0.9016909860692728 0.9893430444711666 0.824289533701172 1.222180351851222 1.1645139962548139 0.9109194068119221 1.0395715268307548 1.0 14.451963060783697 -6.750536290367302 24.999643439357364 1.0679368490372092 0.9394995615145099 0.2903547512059119 0.10807010588803083 317.665564916835 728372.5224477476 0.0364447822853123 0.03610252835112671 1.776084849491326e-07 6.750536290367302 -0.12843728752269934 ISNLLS(ph)DYGYHLR ddPTM_A459_Selumetinib_30min_R1 1 ISNLLSDYGYHLR 13 0 C9J4M6;C9J2Y9;P30876 C9J4M6 POLR2B DNA-directed RNA polymerase;DNA-directed RNA polymerase II subunit RPB2 1 ISNLLS(0.991)DY(0.007)GY(0.002)HLR 82.57799999999997 0.02167 20492000.0 2854.9 2973.2 3335.2 3816.8 2968.6 2680.6 3163.3 2537.7 1533.8 2167.3 True False 2921.413615331618 2625.096361796818 2882.298158942232 3150.267530209487 2700.0906541488966 2653.6355977900635 2924.6897342125603 2470.391952388675 2602.7465756802817 2445.494066289733 1.1946107968946917 1.0734421309717488 1.178615887347137 1.288192669790046 1.1041084463743696 1.085112261922647 1.195950452110422 1.010181127176774 1.0643029609264725 1.0 11.255910248808343 -7.845694372717809 0.9181156555607908 1.0027911491391022 1.1662699017466795 0.4346124877394163 0.06566161530679285 0.5622742370634616 0.8726767824559306 0.06097097801583818 0.02474569647273228 1.4266111935516248e-08 7.845694372717809 0.16347875260757738 ISNLS(ph)PEEEQGLWK ddPTM_A459_Selumetinib_30min_R1 1 ISNLSPEEEQGLWK 14 0 F5GX09;Q5HYJ3-3;Q5HYJ3-2;Q5HYJ3 F5GX09 FAM76B Protein FAM76B 1 IS(0.001)NLS(0.999)PEEEQGLWK 192.23 0.00011013 41498000.0 3006.0 3300.1 4152.1 4724.0 3663.3 2675.5 3148.9 3054.1 1645.2 2850.5 True False 3076.033951342198 2913.7227578251322 3588.267625852736 3899.042080462591 3331.955161808144 2648.586899159635 2911.3759378060654 2973.0953468850726 2791.784239346201 3216.38944122128 0.9563624080839577 0.9058986205099518 1.1156197629134896 1.2122419102899755 1.0359302636384056 0.8234658605750032 0.9051689762731595 0.9243580111232341 0.8679870054187673 1.0 11.65122638362393 -6.6716611151492655 7.630052172439623 0.8998537725628856 1.051910110176329 0.3889799268543602 0.08821951902088165 0.26393123874375635 19.396615686455597 0.0319719865665505 0.03190758533823768 2.1298003047923845e-07 6.6716611151492655 0.1520563376134435 ISNLS(ph)PEEEQGLWK ddPTM_A459_Selumetinib_30min_R2 3 ISNLSPEEEQGLWK 14 0 F5GX09;Q5HYJ3-3;Q5HYJ3-2;Q5HYJ3 F5GX09 FAM76B Protein FAM76B 1 IS(0.001)NLS(0.999)PEEEQGLWK;ISNLS(1)PEEEQGLWK;ISNLS(1)PEEEQGLWK 141.06 0.00055737 28795900.0 222948.0 219518.0 250049.0 278339.0 251783.0 198194.0 189257.0 175488.0 154903.0 229266.0 True False 210557.44269155734 236354.3247383797 233961.11957276592 240428.74803844368 220151.7685714207 225493.42447399956 198057.82550563096 175998.6410263975 185887.92835144623 222646.4948753943 0.9457029306003552 1.0615676876954974 1.0508187865418852 1.0798676537575915 0.9887951242826895 1.0127867703473104 0.8895618393475065 0.790484669991757 0.8349016608389893 1.0 17.764395374042955 -7.283448750896607 3.2165004342312327 0.8560936367554258 1.0294930023155118 0.5617959047371397 0.061886925051539685 0.16479414316376506 3.521105123058331 0.02679532987703705 0.018106100960394753 5.206564454598519e-08 7.283448750896607 0.17339936556008595 ISNYGWDQSDK ddPTM_A459_Selumetinib_30min_R2 1 ISNYGWDQSDK 11 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 136.7 0.019308 3650400.0 13356.0 9621.9 11119.0 15074.0 14631.0 9760.1 13531.0 13480.0 9002.3 12117.0 False True 12613.726988304179 10359.86879071518 10403.615645451851 13020.8951958996 12792.92297720044 11104.465181633555 14160.218311167853 13519.224568265863 10803.011545278145 11767.150726253125 1.0719440314605895 0.8804058885386565 0.8841235986075069 1.1065461383824469 1.0871725258569829 0.9436834319508559 1.2033684823612967 1.148895334373832 0.9180651966304862 1.0 13.522477410993375 -5.765598417991048 24.998525538681537 1.0669297175268786 0.9389826397148573 0.21829803315613028 0.0965725211668523 140.17127686799597 842527.1259979266 0.02698115808952593 0.04169031278796632 1.7155428969426262e-06 5.765598417991048 -0.1279470778120213 ISPPIKEEETKGDS(ph)VEK ddPTM_A459_Selumetinib_30min_R2 1 ISPPIKEEETKGDSVEK 17 2 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V5I6;A0A087WTC9;Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 ISPPIKEEET(0.414)KGDS(0.586)VEK 48.405 0.044325 30666000.0 98593.0 84771.0 90296.0 89048.0 76658.0 68938.0 87482.0 80030.0 46690.0 78900.0 True False 93113.59575905003 91272.66311827335 84486.4536668514 76919.50878363186 67027.53670878483 78433.58374314339 91550.0863422944 80262.8740503202 56029.30462759926 76621.95199318076 1.215233928878985 1.191207751094575 1.1026403200269628 1.0038834404855357 0.8747824215539456 1.0236437692180416 1.1948284265903617 1.0475180018575287 0.731243503592623 1.0 16.225470159357315 -5.517974704096176 2.3095351264329005 0.9898160336941266 1.206661210412366 0.3870417875508346 0.11272357522372699 0.3539854565358948 3.721888057428921 0.03424187179567668 0.0825469745054532 3.034067901278862e-06 5.517974704096176 0.21684517671823933 ISQRDPS(ph)PESNK ddPTM_A459_Selumetinib_30min_R1 2 ISQRDPSPESNK 12 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;Q8NDX5-3 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 ISQRDPS(0.922)PES(0.078)NK;IS(0.001)QRDPS(0.999)PESNK 174.94 0.0005808 71567000.0 8724.400000000001 10097.900000000001 11843.6 12726.7 10082.6 8955.7 9745.8 8810.6 5072.5 6724.4 True False 8927.661545272746 8915.63317361365 10235.304172238006 10504.220754746668 9170.630610227605 8865.613789125002 9010.666459611404 8576.914267137825 8607.662019258201 7587.542241202725 1.1766210007758184 1.1750357217385858 1.3489617384476764 1.3844035948433298 1.2086431045389396 1.1684434178147898 1.187560632042438 1.1303942692486773 1.13444666871387 1.0 12.88941692779371 -8.092925442420626 0.6098388774083527 1.0090156074179093 1.2641730471527644 0.5713520427406638 0.06772416406294376 0.600118699893473 0.507044877111776 0.07514638366090205 0.036938604789857096 8.073736243568052e-09 8.092925442420626 0.25515743973485505 ISQRDPS(ph)PESNK ddPTM_A459_Selumetinib_30min_R2 2 ISQRDPSPESNK 12 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;Q8NDX5-3 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 ISQRDPS(0.982)PES(0.018)NK;ISQRDPS(0.996)PES(0.004)NK 164.66 0.0024315 28705000.0 100780.0 106585.0 105440.0 110535.0 96781.0 60241.0 59223.0 57810.0 42294.0 94277.0 True False 95179.05105430476 114759.72677520844 98656.10519439189 95479.94231648945 84622.50554688225 68538.65093664882 61976.98684814818 57978.217529039284 50753.98179309665 91554.97804893673 1.0395835713425756 1.2534515241090292 1.0775613439791287 1.0428700257615136 0.9242807693280313 0.7486064919377128 0.6769373787083547 0.6332612247260827 0.5543552396022455 1.0 16.482350710260924 -6.493248124932439 1.3783559324451289 0.6818436784554982 1.1365722701344125 0.6868009222651199 0.12132706119736532 0.212827951587099 0.8311889001557692 0.04837284741449409 0.05528295786856332 3.211825006311684e-07 6.493248124932439 0.45472859167891433 ISQRDPSPES(ph)NK ddPTM_A459_Selumetinib_30min_R1 1 ISQRDPSPESNK 12 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;Q8NDX5-3 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 IS(0.002)QRDPS(0.288)PES(0.71)NK 129.76 0.010744 4838100.0 1760.9 1726.1 1852.2 2161.1 1969.3 1698.3 1548.4 1665.7 1123.9 1432.3 True False 1801.925543885057 1524.0074095578802 1600.6814134063316 1783.7044538712325 1791.177162708153 1681.2166439330235 1431.602941376009 1621.5202250438647 1907.1762135917775 1616.1496567834547 1.114949680756263 0.9429865626374226 0.9904289535859514 1.1036752978812954 1.1082990706894356 1.0402604962210422 0.8858108748575054 1.0033230637013522 1.1800740145485902 1.0 10.658345083681459 -10.965030766834627 3.3703416762037164 0.999542712378819 1.0348296577713483 0.016104261987824664 0.08443219285999178 63994739.0874058 26362079.50429526 238619.80952957572 0.021741688654014952 1.0838501278306058e-11 10.965030766834627 0.0352869453925293 ISQSALPPLPGS(ph)PAIQINGEWETHK ddPTM_A459_Selumetinib_30min_R1 1 ISQSALPPLPGSPAIQINGEWETHK 25 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 ISQSALPPLPGS(1)PAIQINGEWETHK 121.65 2.9569e-08 0.0 1060.1 1296.2 1388.9 1261.4 1507.3 936.13 1678.7 1366.9 783.53 1131.8 True False 1084.79826740448 1144.4403014129678 1200.2950086815977 1041.1201694105655 1370.9649811354288 926.7133821380335 1552.0743074708773 1330.645371683052 1329.5931832329977 1277.0775546655834 0.8494380497420504 0.8961400168940028 0.93987636404424 0.8152364479408567 1.073517403956278 0.7256516088255136 1.2153328525747247 1.0419456256370396 1.0411217223069635 1.0 10.318630424686274 -7.266922830165707 24.99990210136053 1.0780955104964853 0.8920159054824022 0.47056061967809903 0.09911728879366857 410.3107883068001 1870660.8898238689 0.038160031386935 0.02657255545432546 5.4085041817808035e-08 7.266922830165707 -0.18607960501408316 ISQSALPPLPGS(ph)PAIQINGEWETHK ddPTM_A459_Selumetinib_30min_R2 3 ISQSALPPLPGSPAIQINGEWETHK 25 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 ISQSALPPLPGS(0.999)PAIQINGEWETHK;ISQSALPPLPGS(1)PAIQINGEWETHK;ISQSALPPLPGS(1)PAIQINGEWETHK 117.22 2.2641e-07 13428100.0 159604.0 141881.0 163684.0 175355.0 159020.0 120249.0 139340.0 142121.0 121754.0 159649.0 True False 150733.84862543424 152762.81648068037 153152.74964566427 151471.34649575275 139042.48594316267 136812.2082382611 145819.58609697188 142534.54858060184 146108.20209099806 155039.51855208277 0.9722285649048754 0.9853153435158689 0.9878304001196658 0.9769854028853208 0.8968196447053196 0.8824344239194828 0.9405317267415687 0.9193433384709583 0.9423932907913127 1.0 17.242276470274057 -6.176145904295716 7.16897298378545 0.9244190062133077 0.98191307328843 0.39515332726417196 0.02999992020595306 0.24564314784461913 17.942825583353986 0.00868522964407671 0.011244173896679872 6.665827884003778e-07 6.176145904295716 0.05749406707512228 ISREPEPAAGPQAEESATVSAPAPMS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 5 ISREPEPAAGPQAEESATVSAPAPMSPTR 29 1 Q9BWG6-2;Q9BWG6 Q9BWG6-2 SCNM1 Sodium channel modifier 1 1 ISREPEPAAGPQAEESATVSAPAPMS(0.94)PT(0.06)R;ISREPEPAAGPQAEESATVSAPAPMS(0.951)PT(0.049)R;ISREPEPAAGPQAEESATVSAPAPMS(0.723)PT(0.277)R;ISREPEPAAGPQAEESATVSAPAPMS(0.945)PT(0.055)R;ISREPEPAAGPQAEESATVS(0.001)APAPMS(0.499)PT(0.499)R 235.77 5.064199999999999e-52 97139800.0 6645.08 7262.8 10315.1 11081.8 8890.8 7391.73 7861.31 6703.08 4184.41 5346.0 True False 6799.897434925158 6412.46799961588 8914.3660767885 9146.571661149519 8086.628709798227 7317.375907353858 7268.325057523006 6525.292543727577 7100.638152785451 6032.211174449734 1.1272644869806723 1.0630377177073602 1.4777940988781246 1.5162883719805915 1.3405745382473118 1.2130503551247702 1.2049188676134224 1.0817413971457692 1.1771202876419824 1.0 12.558471219733947 -7.39763043483252 1.5694040389007677 1.091197078914719 1.3081238779599722 0.3114696062086192 0.13676214874194126 0.5743356624294623 2.7408936929415675 0.09559573542872023 0.05117746963293664 4.0028522968987375e-08 7.39763043483252 0.21692679904525325 ISREPEPAAGPQAEESATVSAPAPMS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 ISREPEPAAGPQAEESATVSAPAPMSPTR 29 1 Q9BWG6-2;Q9BWG6 Q9BWG6-2 SCNM1 Sodium channel modifier 1 1 ISREPEPAAGPQAEESATVSAPAPMS(0.943)PT(0.057)R;ISREPEPAAGPQAEESATVS(0.001)APAPMS(0.709)PT(0.289)R 220.42 1.2539e-46 38818000.0 93409.0 112733.0 119832.0 133374.0 130818.0 85569.0 63590.0 81226.0 50197.0 125703.0 True False 88217.70172585377 121379.25860627275 112122.1395832168 115208.23111701706 114383.47331224152 97355.35303195684 66547.06100119447 81462.35421231175 60237.80262136642 122073.62777438306 0.7226597860178127 0.9943118822568815 0.9184796227276981 0.9437601979843292 0.9370039655382856 0.7975133925886873 0.545138718447747 0.6673214821048064 0.4934546774729932 1.0 16.897392035216043 -7.016512972544681 4.45505666825609 0.649286677056508 0.9094263161530308 0.3528726235330626 0.14248137779801287 0.18999840218699846 9.329493424510968 0.0509219584859319 0.04137183802393841 9.626912565824811e-08 7.016512972544681 0.2601396390965228 ISS(ph)IYAR ddPTM_A459_Selumetinib_30min_R2 1 ISSIYAR 7 0 G8JLG1;Q14683;V9GY57 G8JLG1 SMC1A Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 1A 1 IS(0.211)S(0.789)IYAR 112.41 0.014575 3163500.0 16543.0 15950.0 17800.0 17230.0 20321.0 16478.0 15707.0 15001.0 16440.0 17842.0 True False 15623.606286876011 17173.313712666633 16654.767379174642 14883.244276592137 17768.09430795504 18747.69492760912 16437.40662283004 15044.650426450764 19728.45937197968 17326.855100916753 0.9016989058821976 0.9911385310631474 0.9612112112770799 0.8589697432054287 1.0254656257277146 1.0820021762989864 0.948666479121208 0.8682851180336102 1.1386058957078633 1.0 14.080722202423702 -6.2991304353528035 24.97404850043727 1.0044014885506114 0.935100282767839 0.21771094604437813 0.07540782651964043 1054.9851508690135 699029.1469494516 0.02374776716359283 0.026928185289075635 5.021917393572739e-07 6.2991304353528035 -0.06930120578277243 ISS(ph)LLEEQFQQGK ddPTM_A459_Selumetinib_30min_R2 1 ISSLLEEQFQQGK 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 IS(0.004)S(0.996)LLEEQFQQGK 197.06 0.00017734 4777400.0 29682.0 29788.0 27346.0 31271.0 32762.0 23960.0 28874.0 27451.0 22895.0 26766.0 True False 28032.39326646036 32072.643816483625 25586.588132073593 27011.835854516125 28646.14466400388 27260.27251277548 30216.69821274558 27530.877865242295 27474.639739749084 25993.19603358021 1.0784511927754379 1.233886120623623 0.9843571409617606 1.0391887099847186 1.102063194806686 1.048746467250828 1.162484912348181 1.0591570897890192 1.0569935187752602 1.0 14.665846413063864 -8.873094429058195 0.010516227532274427 8.119219829715347e-06 2.1093837571659373 0.1353534311074719 0.06575609252734596 4178.228670530462 20.909656210704945 2142.954867688866 2048.478213702552 1.3393854319272793e-09 8.873094429058195 2.1093756379461075 ISS(ph)PEDISDSKR ddPTM_A459_Selumetinib_30min_R2 1 ISSPEDISDSKR 12 1 Q8N8V4 Q8N8V4 ANKS4B Ankyrin repeat and SAM domain-containing protein 4B 1 IS(0.211)S(0.787)PEDIS(0.001)DS(0.002)KR 60.901 0.047936 7468700.0 59495.0 49068.0 49674.0 57784.0 46851.0 44013.0 45425.0 47593.0 40980.0 54479.0 True False 56188.506077355225 52831.35782151264 46478.0289209619 49913.719517040045 40965.15852674579 50075.39123976576 47537.35250792986 47731.48775055473 49177.14507686908 52906.04971655894 1.062043119423617 0.9985882163675712 0.8785012143217121 0.9434406799307428 0.7743000799759995 0.9464965066952028 0.8985239450423618 0.9021933787586367 0.9295183696445444 1.0 15.691145081039021 -5.0552169783854755 3.119246186358566 0.903021132311049 1.0577836220267594 0.4439937332429075 0.0558190615222938 0.21427637668143965 3.9397787143296212 0.013930023221293723 0.05803630155756211 8.806088010685142e-06 5.0552169783854755 0.15476248971571038 ISS(ph)PMHPSAGGQR ddPTM_A459_Selumetinib_30min_R2 2 ISSPMHPSAGGQR 13 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 IS(0.043)S(0.927)PMHPS(0.03)AGGQR;IS(0.146)S(0.854)PMHPSAGGQR 112.08 0.005031 16258100.0 55715.0 45215.0 75775.0 102704.0 100324.0 73202.0 51250.0 64682.0 73206.0 79537.0 True False 52618.58334481631 48682.84511086031 70899.71899758211 88715.53802571796 87720.40221206042 83284.91103840528 53633.2265499484 64870.21391131848 87849.24554654185 77240.56014805622 0.6812299554010999 0.6302756610975384 0.9179078823571468 1.1485615569807661 1.1356779656169793 1.0782535869595342 0.694366100493616 0.8398464975781376 1.1373460443340997 1.0 16.23707100629131 -5.347395497627886 4.236375594944417 0.9958324596257592 0.6548458444047713 0.49979132862294817 0.13701928188476892 0.19563464488600216 6.307931527853875 0.04052062825759907 0.09158547920165758 4.493704416959575e-06 5.347395497627886 -0.34098661522098783 ISS(ph)PTETER ddPTM_A459_Selumetinib_30min_R1 3 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 IS(0.023)S(0.976)PT(0.001)ETER;IS(0.017)S(0.982)PT(0.001)ETER;IS(0.033)S(0.963)PT(0.004)ETER 192.12 0.00085111 112368000.0 10584.8 12315.2 12841.199999999999 12679.899999999998 12575.3 10707.8 10982.2 10819.9 6122.6 9255.9 True False 10831.405245564505 10873.33065881885 11097.435571662556 10465.593496201865 11437.866335349541 10600.089253904516 10153.803812180056 10532.921104011592 10389.605022988724 10443.984925100869 1.0370950669923429 1.0411093789197359 1.0625671763458022 1.002068996772397 1.0951630452721162 1.0149468167488895 0.9722154795318215 1.0085155407201876 0.9947931845457332 1.0 13.350384659921238 -6.99251235467696 24.999545561653434 0.994446456335664 1.0464933252600561 0.5433781741292558 0.02332608618218798 133.803727196641 446737.82946132595 0.0077497524057740805 0.006822192848487249 1.0173904233564714e-07 6.99251235467696 0.05204686892439214 ISS(ph)PTETER ddPTM_A459_Selumetinib_30min_R2 3 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 IS(0.016)S(0.983)PT(0.001)ETER;IS(0.031)S(0.968)PT(0.001)ETER;IS(0.039)S(0.959)PT(0.001)ETER 201.61 0.00067933 106075500.0 469654.0 415236.0 497616.0 515636.0 503717.0 331475.0 386398.0 365657.0 315679.0 405492.0 True False 443552.51085392386 447083.26600582124 465599.92832333565 445405.48727828596 440435.56717288407 377132.67241954326 404366.2726331121 366721.00133222487 378823.6208082226 393784.39236525825 1.1263841824449525 1.1353503964959717 1.1823727332785303 1.1310897433058904 1.118468826373276 0.9577136111319782 1.0268722693763812 0.9312735812852367 0.9620077081593457 1.0 18.587046405626843 -6.701964756427319 4.733273153483301 0.9741497953509317 1.1432469640596041 0.8932011476546234 0.028260984222271208 0.06250933990969652 2.8131563765803196 0.009789641891339237 0.009585659475724975 1.9862560981315748e-07 6.701964756427319 0.16909716870867242 ISS(ph)TPPSGSR ddPTM_A459_Selumetinib_30min_R1 1 ISSTPPSGSR 10 0 Q3Y452 Q3Y452 TDRG1 Testis development-related protein 1 1 ISS(0.775)T(0.225)PPSGSR 121.29 0.004823600000000001 11650000.0 3378.1 3562.2 4135.4 3953.3 4191.0 3313.4 3727.4 3250.8 2026.8 2797.5 True False 3456.8031573616377 3145.1359679781476 3573.8353941262008 3262.930367631829 3811.9247899811485 3280.070204326493 3446.239217053045 3164.578223913427 3439.3315683849246 3156.586374957563 1.0951080524156767 0.9963725348781025 1.1321836216739825 1.0336895557548924 1.2076098472142698 1.0391194203803753 1.0917614180918387 1.0025318011315218 1.0895730893570632 1.0 11.624149513354626 -10.934011174008477 7.727332222394759 0.9999978739060443 1.075503418288769 0.126765348741942 0.06014160117900948 2.1048825099524796e-06 1.6040976808185866e-07 0.05563996642437801 0.013494293999715265 1.1640960778745572e-11 10.934011174008477 0.07550554438272472 ISS(ph)VPNSLSK ddPTM_A459_Selumetinib_30min_R1 1 ISSVPNSLSK 10 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 IS(0.15)S(0.849)VPNS(0.001)LSK 119.03 0.0055279 22948000.0 5311.2 6121.8 7266.6 7829.3 6230.5 5359.5 5446.2 5752.0 3298.4 4545.7 True False 5434.940626203821 5405.0568100523915 6279.835632576642 6462.0597291629465 5666.95237508412 5305.588296036653 5035.388749239221 5599.4382748708085 5597.1438943955145 5129.1848738675935 1.059610983003168 1.0537847519574355 1.2243340388394726 1.2598609502430191 1.1048446321278784 1.0343920966989917 0.9817132493885629 1.0916818973320856 1.0912345785998279 1.0 12.324513856719218 -6.581977450205536 4.964114976817754 1.0430553711050627 1.1517991732452606 0.36943962156503296 0.06750888298722837 0.2489178171405564 12.536454479784249 0.025036374036218608 0.025246391548813127 2.618318955194918e-07 6.581977450205536 0.10874380214019785 ISS(ph)VPNSLSK ddPTM_A459_Selumetinib_30min_R2 1 ISSVPNSLSK 10 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 IS(0.003)S(0.997)VPNS(0.001)LSK 85.81299999999997 0.035938 3026200.0 23287.0 21723.0 27445.0 30253.0 29234.0 20859.0 23187.0 27768.0 16214.0 24871.0 True False 21992.801765247026 23389.08424954591 25679.218579856635 26132.48921066409 25561.363564724037 23732.13791085075 24265.241444168845 27848.800282760123 19457.253057012076 24152.9096073815 0.9105653158460746 0.9683754309417796 1.0631935860849109 1.0819602952796048 1.0583140491244205 0.982578840256904 1.0046508614743879 1.1530205153522828 0.8055862988476402 1.0 14.55990937495796 -4.988751653912596 3.8239458709444474 1.025887662710029 0.915927886631896 0.13164268893857334 0.08569407939474441 0.3892200026337286 12.497514328330935 0.020827910937720986 0.09011507532626949 1.0262386007217305e-05 4.988751653912596 -0.10995977607813312 ISSCS(ph)DESSNSNSSR ddPTM_A459_Selumetinib_30min_R2 1 ISSCSDESSNSNSSR 15 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 ISS(0.002)CS(0.998)DESSNSNSSR 141.1 0.00032715 0.0 5921.3 6030.7 6462.1 7887.2 6006.2 4565.8 4833.2 4955.9 4654.0 6787.0 True False 5592.217850841979 6493.235298243173 6046.335521402496 6812.9497538211035 5251.647459890731 5194.697505794254 5057.953376804109 4970.320848506586 5584.930043624907 6591.041675256256 0.8484573647646609 0.9851607102743315 0.917356590855939 1.0336681346437124 0.796785655233556 0.7881451463576562 0.7673981786205986 0.7541024762695561 0.8473516507400581 1.0 12.686290777355849 -6.282895351724935 24.586450118072925 0.8085497420617213 0.9468889806560741 0.34478342777076965 0.0793270352632775 609.5356711235912 698466.3772301176 0.023260591377452868 0.026400820468944083 5.213203141269213e-07 6.282895351724935 0.13833923859435282 ISSDLDGHPVPK ddPTM_A459_Selumetinib_30min_R1 1 ISSDLDGHPVPK 12 0 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 0 93.258 0.028867 2758500.0 3335.4 5803.3 4683.8 5049.9 5247.0 4739.9 4945.8 4309.5 1788.8 3454.5 False True 3413.108330441376 5123.846938119024 4047.765686271776 4168.029763363262 4772.409776433091 4692.220909484864 4572.734324113578 4195.198060771169 3035.462951217164 3897.9187246794972 0.8756232675739065 1.3145084082122127 1.0384428132489087 1.0692962213330843 1.2243482005452788 1.2037759740284677 1.1731220292412758 1.0762661710233878 0.7787394159858354 1.0 11.92848829400487 -8.091204943235386 5.546342347131179 0.8931512052578079 1.1358190874710419 0.367154736658857 0.12334230154567236 0.2223583885810129 10.458098783601633 0.08115789437515027 0.029867018504622152 8.105784562298238e-09 8.091204943235386 0.242667882213234 ISSDLDGHPVPK ddPTM_A459_Selumetinib_30min_R2 1 ISSDLDGHPVPK 12 0 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 0 105.46 0.013085 18303000.0 68455.0 54309.0 80843.0 88716.0 92211.0 65715.0 62708.0 70060.0 61098.0 78845.0 False True 64650.54514707711 58474.32566904154 75641.64939520323 76632.72775636375 80626.6298032008 74766.64474862452 65624.04625354467 70263.86300094269 73319.30722075513 76568.53998608814 0.8443486732125696 0.7636860475551164 0.9878946289030284 1.0008383047435312 1.0529994409956096 0.9764668983137067 0.8570627866936996 0.9176596943563118 0.957564389161353 1.0 16.2244641277181 -5.265469601331422 24.99821658248906 0.9663030586999962 0.8040173547333335 0.6074797723912266 0.05295577661777138 230.85081410187644 1431905.026451533 0.015488604877824441 0.03424254209943919 5.426632339955434e-06 5.265469601331422 -0.16228570396666275 ISSIQSIVPALEIANAHR ddPTM_A459_Selumetinib_30min_R1 2 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 ; 118.15 0.0014098 18490200.0 7751.4 12172.900000000001 9680.7 11189.7 9607.8 10460.5 9251.5 8601.5 4916.1 6955.1 False True 7931.992538401168 10747.691208972317 8366.114112278738 9235.628951683373 8738.776186394858 10355.276867374083 8553.651906574623 8373.360278390352 8342.262642262245 7847.854833411021 1.0107211087330443 1.3695068827236323 1.0660383365733663 1.176834835471742 1.1135241886981495 1.3195041303883581 1.0899350316928367 1.0669616673771887 1.0629991022191645 1.0 12.938082640050151 -7.506152662016196 24.15409770791156 1.0546778502217797 1.1793221657438298 0.2578104751821325 0.1022869079900759 637.9176481532605 921220.695554954 0.04116496431110263 0.02693302322482244 3.117793433171395e-08 7.506152662016196 0.12464431552205002 ISSLPVSRPIS(ph)PSPSAILER ddPTM_A459_Selumetinib_30min_R1 1 ISSLPVSRPISPSPSAILER 20 1 Q5T5P2-3;Q5T5P2;Q5T5P2-4;Q5T5P2-8;Q5T5P2-6;Q5T5P2-9;Q5T5P2-2;Q5T5P2-7;Q5T5P2-10;Q5T5P0;Q5T5P1 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 ISS(0.001)LPVS(0.054)RPIS(0.64)PS(0.269)PS(0.035)AILER 58.938 0.018669 80407000.0 2575.4 2681.3 2767.8 3166.7 2800.5 2376.1 2352.3 2472.7 1330.9 2110.4 True False 2635.401809143945 2367.372149497447 2391.947962437127 2613.6952913211035 2547.1952694684333 2352.198591326185 2174.8641171524064 2407.1159635384306 2258.4400949099545 2381.2903970367965 1.1067116435791942 0.9941551658056199 1.0044755420899494 1.0975962001835242 1.0696701555753483 0.9877831759844107 0.9133132690824854 1.0108451982730753 0.9484101971436524 1.0 11.217527851855051 -6.880288241936728 5.201833989456234 0.9667596960397651 1.0504709769595375 0.49690306761272895 0.04165890838225705 0.18986427717870438 7.880584009369105 0.015097388784272988 0.0133125377876674 1.3173820997490575e-07 6.880288241936728 0.08371128091977242 ISSPTETER ddPTM_A459_Selumetinib_30min_R1 1 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 148.99 0.020418 11769000.0 1279.2 1654.2 1421.4 1941.3 1541.5 1393.1 1409.4 1118.3 921.04 1276.5 False True 1309.002871110093 1460.525494983283 1228.381687191319 1602.288397714231 1402.0715971739287 1379.0866788335957 1303.0878232855507 1088.6390512496575 1562.9376098999649 1440.3512091629416 0.908808117619326 1.0140065045886035 0.8528348359600376 1.1124289600488475 0.9734234180209013 0.9574655612189545 0.9047014471163868 0.7558150014553179 1.0851086873515134 1.0 10.492204919897988 -7.090571291922007 4.186868649370901 0.9165943986234514 0.9750426923917808 0.01203904879410167 0.10054218833959223 0.704396083755664 21.970880684949087 0.03831578350666198 0.029681591057799286 8.117619826275792e-08 7.090571291922007 0.058448293768329385 ISST(ph)PPSGSR ddPTM_A459_Selumetinib_30min_R1 2 ISSTPPSGSR 10 0 Q3Y452 Q3Y452 TDRG1 Testis development-related protein 1 1 IS(0.003)S(0.086)T(0.907)PPS(0.004)GSR;ISS(0.207)T(0.791)PPSGS(0.002)R 112.94 0.018553 159742000.0 11464.8 13629.8 13224.2 15253.099999999999 13839.2 11270.7 12927.900000000001 11477.6 6801.6 9312.400000000001 True False 11731.90753338259 12034.016679677883 11428.426275330978 12589.43242114817 12587.446803509216 11157.32699097682 11952.738094688006 11173.176763500904 11541.818430790849 10507.737250457485 1.1165017980319032 1.145252911529925 1.0876201034464779 1.1981106989137984 1.1979217317183284 1.06182013549026 1.1375177937731178 1.0633285261310133 1.0984114044427922 1.0 13.359164410504654 -8.486358404670723 0.5998237653856752 1.0011752657988409 1.1429370685149178 0.4900620369548717 0.04210551477965785 0.7492416993644845 0.638242961657538 0.044699842275934175 0.019593785550311285 3.26318424376058e-09 8.486358404670723 0.14176180271607697 ISST(ph)PTTETIR ddPTM_A459_Selumetinib_30min_R1 2 ISSTPTTETIR 11 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 ISS(0.025)T(0.944)PT(0.018)T(0.012)ETIR;ISS(0.005)T(0.963)PT(0.028)T(0.004)ET(0.001)IR 155.48 0.0012507 15304900.0 5774.6 9797.0 6801.5 8822.8 8189.0 7630.1 8223.9 5788.4 3016.9 4616.3 True False 5909.136944584385 8649.962685498265 5877.893657965216 7282.063604467688 7448.306395885379 7553.3481215765 7603.564601900122 5634.872828626944 5119.458954342057 5208.8470715698295 1.1344423945246493 1.6606290349183472 1.1284442751347183 1.3980183146887892 1.429933782571318 1.45009980477313 1.4597404180669444 1.0817888778847793 0.9828391741973656 1.0 12.34674836576557 -7.859112866667544 4.8526831961018715 1.0055220699396545 1.3861614616594513 0.5555947976420071 0.14788641981041548 0.1487609576992978 5.781078984094953 0.07983466913090671 0.03716470560405902 1.3832068573956473e-08 7.859112866667544 0.38063939171979677 IST(ph)PLTGVR ddPTM_A459_Selumetinib_30min_R1 1 ISTPLTGVR 9 0 Q08999;F5H837;Q08999-2 Q08999 RBL2 Retinoblastoma-like protein 2 1 IS(0.046)T(0.954)PLTGVR 107.55 0.029282 11225000.0 5980.2 7118.1 7798.8 8233.0 5973.7 6204.0 5935.9 6311.1 3230.0 5080.9 True False 6119.527024556426 6284.70954288509 6739.765795741983 6795.261102550488 5433.379889742398 6141.593392781297 5488.150283979489 6143.709126658064 5481.0740901338595 5733.083007157061 1.0674059693391735 1.0962181316822712 1.1755918739233673 1.1852717105381916 0.9477239179965613 1.0712549225459076 0.957277310851456 1.0716239620093388 0.9560430371043644 1.0 12.48509545208984 -6.260225992443901 24.999671316642022 1.0055962820015227 1.1318052193719383 0.6009298004227182 0.05199147693123194 78.41046608199142 1615505.2726975651 0.015520497774021957 0.01893678901766953 5.492549854036755e-07 6.260225992443901 0.1262089373704156 IST(ph)PLTGVR ddPTM_A459_Selumetinib_30min_R2 3 ISTPLTGVR 9 0 Q08999;F5H837;Q08999-2 Q08999 RBL2 Retinoblastoma-like protein 2 1 IS(0.12)T(0.88)PLTGVR;IS(0.049)T(0.951)PLTGVR;IS(0.468)T(0.532)PLTGVR 110.38 0.025454 22329100.0 160163.0 142517.0 165056.0 178617.0 166390.0 132181.0 143585.0 142396.0 111687.0 154821.0 True False 151261.78164328844 153447.59563561814 154436.47665938464 154289.05646848842 145486.60065452688 150387.73293034974 150261.98700827974 142810.34878507315 134027.52079551702 150350.91545673343 1.0060582683104256 1.0205963506738729 1.0271735040005587 1.0261929965626864 0.9676469226181309 1.0002448769500636 0.9994085273895171 0.9498468855427074 0.8914313583550224 1.0 17.197974126657797 -7.7689249921324715 3.8237894469293807 0.9382016026170099 1.0077334472942812 0.4636706321129255 0.02928830962143208 0.17635611725715314 5.597331110996837 0.016315817669030036 0.007896900495697802 1.70245251697989e-08 7.7689249921324715 0.06953184467727125 IST(ph)PQTNTVPIKPLISTPPVSSQPK ddPTM_A459_Selumetinib_30min_R2 1 ISTPQTNTVPIKPLISTPPVSSQPK 25 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 IS(0.074)T(0.882)PQT(0.025)NT(0.018)VPIKPLISTPPVSSQPK 83.318 0.00018061 6365900.0 38281.0 38527.0 36941.0 35670.0 36533.0 36837.0 34980.0 33213.0 22928.0 38754.0 True False 36153.49527098475 41481.89701616974 34564.25627831968 30811.684465817863 31943.39793083615 41910.96237700798 36606.63931155503 33309.64433129184 27514.240661846132 37635.071325015575 0.960633100938325 1.1022138541450626 0.9184054941685532 0.8186960561261833 0.8487667700952053 1.1136145329728728 0.9726735734182878 0.8850692494676189 0.731079806498407 1.0 15.199790085178678 -5.348387740762952 8.29306879583185 0.9105289733675637 1.0310620990493635 0.17654340078550723 0.10405175782691638 0.5290873926884966 45.733170224644844 0.028691623808582915 0.05997551103848902 4.4834492610620486e-06 5.348387740762952 0.12053312568179986 ISTAS(ph)GDGR ddPTM_A459_Selumetinib_30min_R1 1 ISTASGDGR 9 0 A0A0A0MR13;A0A590UJY2;A0A590UJF0;B0AZR9;A0A590UJ58;P63092-3;P63092-2;P63092;P63092-4;Q5JWF2-2;Q5JWF2 A0A0A0MR13 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 IST(0.006)AS(0.993)GDGR 97.597 0.02045 7849500.0 2374.6 2132.8 2612.6 1964.5 2773.0 2312.1 2335.1 2887.6 1642.7 1819.0 True False 2429.9235598327305 1883.0907844881804 2257.8232699845507 1621.4369532321678 2522.182639612913 2288.8423732188344 2158.961527000205 2811.0114677532965 2787.5419219389755 2052.48636856043 1.1838926665013745 0.9174681076244808 1.1000430037292475 0.7899867098115779 1.2288425775913523 1.1151559436782907 1.0518761829899286 1.3695640130973827 1.3581293228729687 1.0 11.003156925142354 -7.050856116868856 1.1614268039632247 1.2447011925528804 1.0148004358633085 0.19621197207440833 0.15621051609940692 0.6672732609135916 1.828428824938525 0.09248017685016448 0.06347658575840097 8.894957617973991e-08 7.050856116868856 -0.22990075668957188 ISTPQT(ph)NTVPIKPLISTPPVSSQPK ddPTM_A459_Selumetinib_30min_R2 1 ISTPQTNTVPIKPLISTPPVSSQPK 25 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 IS(0.06)T(0.208)PQT(0.411)NT(0.317)VPIKPLIS(0.001)T(0.002)PPVSSQPK 61.039 0.0085102 7003200.0 35162.0 32463.0 29400.0 37368.0 31930.0 31721.0 31244.0 30302.0 21602.0 32406.0 True False 33207.83680463847 34952.807715002935 27508.43600829969 32278.413936604495 27918.667942178236 36090.279815432004 32696.90790881148 30390.173803233847 25923.00361031054 31470.35457910036 1.0552101254903554 1.1106582109569014 0.8741063256582497 1.0256768431214554 0.8871418296862528 1.1468024525977143 1.0389748811577002 0.96567624387099 0.8237277258873389 1.0 14.94170581324228 -8.006495095625333 7.942873016358672 0.9059520300262391 1.0167291538583603 0.18924317852714456 0.08974447419146417 0.2032053672722668 102.88747343852764 0.05370665013339645 0.02315023597237082 9.85155767849164e-09 8.006495095625333 0.11077712383212113 ISVGRLS(ph)PQQESSASSK ddPTM_A459_Selumetinib_30min_R2 1 ISVGRLSPQQESSASSK 17 1 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 IS(0.007)VGRLS(0.993)PQQESSASSK 112.36 0.0010614 12714000.0 27214.0 26616.0 26263.0 27871.0 27471.0 20297.0 22453.0 22642.0 20828.0 25579.0 True False 25701.55482627356 28657.36161607115 24573.267172992353 24074.92171984328 24019.84738614402 23092.727512178804 23497.108989775454 22707.884471415127 24994.1819829436 24840.467807776575 1.0346646860743667 1.1536562772420758 0.9892433332233553 0.9691814947344256 0.9669643732967199 0.9296414097704464 0.9459205507562717 0.9141488255026413 1.0061880547643673 1.0 14.600404722898675 -5.4263971640178745 5.05675200739363 0.9577645721673166 1.0930786954877627 0.6531409964066259 0.037910698892858516 0.11584764888800138 4.649295971432198 0.00954620530774973 0.020347805809200654 3.746302447053493e-06 5.4263971640178745 0.13531412332044612 ISVSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 2 ISVSSPGR 8 0 O75864-2;O75864 O75864-2 PPP1R37 Protein phosphatase 1 regulatory subunit 37 1 ISVS(0.028)S(0.971)PGR;ISVS(0.002)S(0.998)PGR 114.89 0.01011 86646000.0 19660.8 23772.0 24731.0 24898.0 23100.0 18705.7 22332.0 20161.8 11394.400000000001 17813.4 True False 20118.85838674276 20988.76318869702 21372.666037658997 20550.031693344117 21010.609078636233 18517.53764141669 20647.47926040364 19627.043569243786 19335.464585950842 20099.923407209655 1.0009420423724755 1.0442210531592646 1.063320770167354 1.0223935324038604 1.045307917496836 0.9212740400182132 1.0272416885428322 0.9764735502526217 0.9619670778952019 1.0 14.294902383428811 -6.717534734416777 24.999989293171097 0.9790363415833903 1.0365829096683872 0.4889836326252679 0.029527353184313456 115.1212159727817 65551.44260618993 0.009400325321534073 0.009400273719549775 1.9163077923206135e-07 6.717534734416777 0.05754656808499692 ISVSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 4 ISVSSPGR 8 0 O75864-2;O75864 O75864-2 PPP1R37 Protein phosphatase 1 regulatory subunit 37 1 IS(0.001)VS(0.049)S(0.949)PGR;IS(0.013)VS(0.085)S(0.901)PGR;IS(0.002)VS(0.083)S(0.914)PGR;ISVS(0.091)S(0.909)PGR 99.013 0.018995 110376000.0 754260.0 711320.0 852700.0 860870.0 875060.0 569990.0 641430.0 661070.0 566810.0 701880.0 True False 712341.2487420114 765875.9567457067 797838.2103495625 743618.0209164176 765127.1396643431 648500.948645948 671257.7659694321 662993.6042539699 680187.837994636 681614.9006967541 1.04507875049951 1.1236197388918876 1.1705116914756466 1.0909650304831706 1.1225211462986238 0.9514183859288335 0.9848050054118024 0.972680620063104 0.9979063504910775 1.0 19.378597348918312 -6.756349113916732 24.99995468347011 0.9798697883554544 1.1135103269699136 0.8027066822731947 0.031999683053410125 53.20798826829076 261321.84479304374 0.010836095939516305 0.010521367435490968 1.7524711860936854e-07 6.756349113916732 0.13364053861445924 ISYIPDEEVS(ph)SPSPPQR ddPTM_A459_Selumetinib_30min_R1 3 ISYIPDEEVSSPSPPQR 17 0 F8W930;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4;Q9Y6M1-1;Q9Y6M1 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 ISYIPDEEVS(0.686)S(0.313)PS(0.001)PPQR;ISYIPDEEVS(0.5)S(0.5)PS(0.001)PPQR;ISYIPDEEVS(0.91)S(0.088)PS(0.002)PPQR 223.14 3.1575e-12 54574000.0 13012.6 14984.3 13595.1 14550.2 13856.5 12131.3 16106.5 16064.4 9260.9 11727.2 True False 13315.768261888064 13229.931189987923 11748.96009253884 12009.280711081039 12603.182021563774 12009.270136339104 14891.573737582454 15638.319927474737 15715.07091062558 13232.500352601373 1.0062926814334316 0.9998058445082191 0.8878866260698127 0.9075594476534541 0.952441465009001 0.9075586485042644 1.1253786768012384 1.1818114121115746 1.1876115996124768 1.0 13.69179807196518 -7.283904035507955 9.9218911658662 1.1390196929572027 0.9423773775809993 0.6776634319261188 0.06048314637369525 0.27049192099868136 116.23295533261063 0.02509750599965383 0.01718705886753088 5.2011091087711785e-08 7.283904035507955 -0.19664231537620347 ISYIPDEEVS(ph)SPSPPQR ddPTM_A459_Selumetinib_30min_R2 2 ISYIPDEEVSSPSPPQR 17 0 F8W930;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4;Q9Y6M1-1;Q9Y6M1 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 ISYIPDEEVS(0.499)S(0.499)PS(0.003)PPQR;ISYIPDEEVS(0.49)S(0.49)PS(0.021)PPQR 193.3 8.578099999999999e-08 20030700.0 191730.0 183071.0 205652.0 244143.0 242608.0 168021.0 213720.0 190566.0 165566.0 218281.0 True False 181074.4141560018 197111.95703395523 192420.5742169678 210890.30222983405 212129.4140969613 191164.3676072223 223658.40347814566 191120.51551010023 198683.82630055933 211978.66036785135 0.8542105787524993 0.9298669813834204 0.907735589436484 0.9948657183882158 1.000711174081619 0.9018094900472078 1.055098674036463 0.9016026197091938 0.9372822054624688 1.0 17.693559512192046 -4.608218491842522 1.0392551462988637 0.9661527032107166 0.7722932651272858 0.3410226471808028 0.047539490596766446 2.933021836179915 2.034977983321598 0.01496204518247301 0.6877898268871064 2.4647989945930337e-05 4.608218491842522 -0.19385943808343076 ISYIPDEEVSS(ph)PSPPQR ddPTM_A459_Selumetinib_30min_R1 1 ISYIPDEEVSSPSPPQR 17 0 F8W930;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4;Q9Y6M1-1;Q9Y6M1 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 ISYIPDEEVS(0.238)S(0.698)PS(0.064)PPQR 195.5 9.3875e-08 24945000.0 4256.3 4511.2 4211.2 4968.7 4875.6 4029.1 4365.2 4072.2 2197.9 3832.2 True False 4355.4635086819035 3983.02660680002 3639.342170465797 4101.009819050481 4434.602840857092 3988.5709121300997 4035.92944955732 3964.1920276301994 3729.675771735359 4324.100198789049 1.0072531413360029 0.9211226437156694 0.8416414983827119 0.948407675705331 1.0255550604722317 0.922404830777762 0.9333570602012344 0.9167669215297924 0.862532226422469 1.0 12.078184238498112 -10.476269340791449 6.6440920701815065 1.0000000076999587 0.9307758490121862 0.13223873754592275 0.053019856642772666 6.286968680231509e-09 9.554857163401205e-10 0.053253689631375174 0.01291591555300154 3.3398784317199355e-11 10.476269340791449 -0.06922415868777243 ISYIPDEEVSS(ph)PSPPQR ddPTM_A459_Selumetinib_30min_R2 1 ISYIPDEEVSSPSPPQR 17 0 F8W930;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4;Q9Y6M1-1;Q9Y6M1 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 ISYIPDEEVS(0.129)S(0.87)PS(0.001)PPQR 250.38 1.5121e-30 13448000.0 147400.0 123060.0 144200.0 162900.0 169950.0 117110.0 115980.0 133990.0 132740.0 147290.0 True False 139208.09808895134 132498.30629973367 134922.32899308868 140712.7389818258 148599.36162772312 133240.8394812663 121373.29981001014 134379.8887167615 159291.70906548566 143037.35499462084 0.9732289729084161 0.926319605845036 0.9432663865894518 0.9837481893252118 1.0388849935970323 0.9315107895156273 0.8485426748458442 0.9394740885820706 1.1136371269692178 1.0 17.1260324384181 -8.244451650274561 24.524040559228734 1.056818562227883 0.9475733186133629 0.4085593148260358 0.05230898445481803 567.7867928544828 819679.4876696998 0.0377696671687646 0.014180093433259168 5.69571630641793e-09 8.244451650274561 -0.10924524361452004 ISYIPDEEVSSPS(ph)PPQR ddPTM_A459_Selumetinib_30min_R2 2 ISYIPDEEVSSPSPPQR 17 0 F8W930;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4;Q9Y6M1-1;Q9Y6M1 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 ISYIPDEEVS(0.235)S(0.235)PS(0.529)PPQR;ISYIPDEEVS(0.2)S(0.122)PS(0.678)PPQR 188.0 6.6234e-08 13430000.0 77162.0 72097.6 78419.0 92825.0 91987.0 71011.6 66823.6 70606.3 60620.8 73252.0 True False 72873.64494395982 77627.25408967737 73373.6069161516 80182.07486794327 80430.77068578613 80792.80332087683 69931.0298084513 70811.75264349773 72746.65388667303 71137.02442844714 1.0244123299992602 1.0912356078058676 1.0314404841314964 1.1271496876931373 1.1306456986640911 1.1357349280492033 0.9830468784759351 0.9954275317591252 1.0226271687796686 1.0 16.118313009106593 -7.272422049131189 24.991599495497372 0.9998943507631743 1.0910148953096692 0.5859245680424168 0.03698898611608526 566.3186710737202 1288680.871855981 0.016454598702919248 0.011214615212900557 5.340451199343138e-08 7.272422049131189 0.09112054454649487 ISYT(ph)PPES(ph)PVPSYASSTPLHVPVPR ddPTM_A459_Selumetinib_30min_R1 3 ISYTPPESPVPSYASSTPLHVPVPR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 2 IS(0.102)Y(0.398)T(0.511)PPES(0.988)PVPS(0.001)YASSTPLHVPVPR;IS(0.229)Y(0.122)T(0.772)PPES(0.877)PVPSYASSTPLHVPVPR;IS(0.193)Y(0.474)T(0.524)PPES(0.798)PVPS(0.005)Y(0.004)AS(0.001)STPLHVPVPR 84.70700000000002 0.0014799 6110100.0 2281.54 2801.2200000000003 3073.19 2794.3900000000003 3116.27 2529.7799999999997 2770.55 2662.83 1320.338 2130.8 True False 2334.695442895968 2473.2518601481524 2655.867677824321 2306.402243696837 2834.4039287221553 2504.3327100564597 2561.565182917398 2592.203098309153 2240.5171523279123 2404.3089357496247 0.9710463610484598 1.0286747361678097 1.104628293949365 0.959278655668157 1.1788850786092653 1.0416018810310037 1.065406007035757 1.078148926606616 0.9318757331945594 1.0 11.231406568164656 -8.25701699885105 24.936401364889313 0.9659378644018015 1.0553828167208494 0.244059563541155 0.06153781762956202 460.05906742259293 2594166.225025681 0.043349373661433196 0.015084126853916278 5.5332845079641135e-09 8.25701699885105 0.08944495231904792 ISYT(ph)PPES(ph)PVPSYASSTPLHVPVPR ddPTM_A459_Selumetinib_30min_R2 5 ISYTPPESPVPSYASSTPLHVPVPR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 2 IS(0.144)Y(0.402)T(0.468)PPES(0.979)PVPS(0.005)Y(0.001)ASSTPLHVPVPR;IS(0.123)Y(0.348)T(0.555)PPES(0.974)PVPSYASSTPLHVPVPR;IS(0.049)Y(0.013)T(0.939)PPES(0.998)PVPSYASSTPLHVPVPR;IS(0.113)Y(0.404)T(0.489)PPES(0.992)PVPS(0.001)YASSTPLHVPVPR;IS(0.161)Y(0.274)T(0.576)PPES(0.989)PVPSYASSTPLHVPVPR 102.21 7.1963e-06 13641500.0 43906.6 39524.4 49402.9 57281.100000000006 63089.3 39929.1 36554.8 43242.5 42411.2 52238.9 True False 41466.44694404583 42555.79438902327 46224.37119981049 49479.31536459095 55163.45810850195 45428.971084718854 38254.670631962035 43368.32851581878 50894.625067938265 50730.62722403768 0.8173848661661686 0.8388580373959791 0.9111728699050662 0.9753341930128192 1.0873797768138744 0.8954939761358451 0.7540744659635479 0.8548746760865905 1.0032327186331904 1.0 15.630569377341875 -6.578327836900994 0.01254264446734279 1.812823929857312 7.070348714110483e-07 0.10754876196125918 0.09138865539106045 6133.642180188213 26.596470927491648 1845.5185040521244 1996.6290310126826 2.6404148286596557e-07 6.578327836900994 -1.8128232228224408 ISYT(ph)PPESPVPSYASSTPLHVPVPR ddPTM_A459_Selumetinib_30min_R1 2 ISYTPPESPVPSYASSTPLHVPVPR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 1 IS(0.071)Y(0.007)T(0.919)PPES(0.003)PVPSYASSTPLHVPVPR;IS(0.042)Y(0.002)T(0.952)PPES(0.004)PVPSYASSTPLHVPVPR 145.19 1.5448e-09 82344000.0 2911.2 3528.9 3353.8999999999996 4244.6 4335.9 3156.2 3704.7 3122.8999999999996 1256.9299999999998 2637.8999999999996 True False 2979.025295790888 3115.7347474588983 2898.4588016539774 3503.3602910100585 3943.7186105653204 3124.451493600311 3425.2514963289177 3040.070547391176 2132.9184074649984 2976.5001603219125 1.000848357242723 1.0467779538509843 0.9737808316934561 1.1770065856912857 1.3249515868122117 1.049706475830459 1.150764761241764 1.021357427732303 0.7165860213608456 1.0 11.53940125673536 -8.042995148696889 6.569256400561046 0.8589745813098182 1.1044495909454006 0.41912001930840315 0.1141853177961748 0.2159385352227971 24.848510182332323 0.07874988661466048 0.03024488472819145 9.057427184753495e-09 8.042995148696889 0.24547500963558244 ISYT(ph)PPESPVPSYASSTPLHVPVPR ddPTM_A459_Selumetinib_30min_R2 1 ISYTPPESPVPSYASSTPLHVPVPR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 1 IS(0.058)Y(0.067)T(0.658)PPES(0.217)PVPSYASSTPLHVPVPR 98.225 7.4019e-06 11758000.0 31617.0 27273.0 31349.0 40003.0 43744.0 29062.0 23123.0 34549.0 24137.0 33192.0 True False 29859.85371287909 29364.7514034832 29332.03947021045 34554.52239097593 38248.48764367824 33065.02670143077 24198.26531735527 34649.531870105144 28965.07444412855 32233.66071682711 0.9263562700866671 0.9109964785400176 0.9099816408658197 1.0720011820729145 1.1866008015562186 1.0257918575214653 0.7507141534415581 1.0749487057800067 0.898597112459143 1.0 14.976280421440784 -5.72856435326615 24.6915162091943 1.0026673894852878 0.9152998386605251 0.11416315583652814 0.1090345047350839 406.05034023898685 304969.6014871199 0.03153775634994132 0.0546198061765117 1.8682528211498632e-06 5.72856435326615 -0.08736755082476266 ISYTPPES(ph)PVPSYASSTPLHVPVPR ddPTM_A459_Selumetinib_30min_R2 1 ISYTPPESPVPSYASSTPLHVPVPR 25 0 P41212 P41212 ETV6 Transcription factor ETV6 1 IS(0.136)Y(0.037)T(0.354)PPES(0.47)PVPS(0.001)YASSTPLHVPVPR 57.216 0.0071562 11783000.0 21189.0 18624.0 23698.0 23667.0 23031.0 17704.0 19393.0 15698.0 15371.0 20786.0 True False 20011.400206287595 20052.40091440145 22173.296480431494 20443.51377214778 20137.63988024765 20142.56529908919 20294.81292650047 15743.6785810562 18445.629501624062 20185.854171486153 0.9913576129245506 0.9933887733483572 1.098457181552056 1.012764364513521 0.9976114812467729 0.9978554847355376 1.0053977777749048 0.7799362091545862 0.913789891917466 1.0 14.301057015805275 -7.631187818036426 9.90250545138552 0.8853634004328248 1.0158105405773092 0.4525020583338223 0.05802129351883591 0.23941079113620084 20.344055469019324 0.02639206008138706 0.015210032492429476 2.3378259873920088e-08 7.631187818036426 0.13044714014448444 IT(ph)HSPTVSQVTER ddPTM_A459_Selumetinib_30min_R1 1 ITHSPTVSQVTER 13 0 P16157-14;H0YBS0;P16157-15;P16157-12;P16157-21;P16157;P16157-3;P16157-16;P16157-5;P16157-8;P16157-10;P16157-13;P16157-4;P16157-7;P16157-6;P16157-9;P16157-11;A0A2R8Y4B0 P16157-14 ANK1 Ankyrin-1 1 IT(0.946)HS(0.043)PT(0.007)VS(0.004)QVTER 108.66 0.014499 6922700.0 1699.8 1949.4 2090.8 2222.8 2484.4 1993.9 2125.9 1512.9 974.45 1173.2 True False 1739.4020327649603 1721.1633417485266 1806.880843942317 1834.6297071236766 2259.686458656445 1973.843176316349 1965.5416514280905 1472.7729774082152 1653.5704789879062 1323.791647935733 1.3139545301387219 1.3001769156290108 1.364928421145347 1.3858900756660035 1.7069804467947118 1.49105274942192 1.4847817286754124 1.1125413728850742 1.2491168693853123 1.0 10.370460358360463 -7.764147588763329 24.99981491203674 1.1356217566431375 1.4381662909437207 0.5777426774286893 0.12312773609201308 58.47661457965396 539782.3059737544 0.06961704143698426 0.03581697502373119 1.7212835220136177e-08 7.764147588763329 0.30254453430058326 IT(ph)KPGSIDSNNQLFAPGGR ddPTM_A459_Selumetinib_30min_R2 1 ITKPGSIDSNNQLFAPGGR 19 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 IT(0.999)KPGS(0.001)IDSNNQLFAPGGR 70.335 0.022343 8026600.0 26065.0 24594.0 23975.0 24054.0 20440.0 14654.0 19493.0 16450.0 17922.0 19312.0 True False 24616.41164646212 26480.280717825906 22432.47460200631 20777.803704535545 17872.144464081528 16672.45548423256 20399.463124646725 16497.866776555904 21506.900782519468 18754.412381398088 1.3125664054864423 1.4119493684638642 1.196117166766386 1.1078888147487038 0.9529567816162743 0.8889884228401336 1.0877153978378076 0.879679215805216 1.1467648436616167 1.0 14.194942440324155 -5.68409491256627 1.8137223985170774 0.9881932075672433 1.364116643552586 0.7505088199591693 0.08340162763672718 0.15769682077270558 1.0473561445391335 0.02431333987340266 0.05476812115404498 2.0696889807144224e-06 5.68409491256627 0.3759234359853427 IT(ph)LGDS(ph)IMKPVS(ph) ddPTM_A459_Selumetinib_30min_R1 1 ITLGDSIMKPVS 12 1 Q8WXD0-2;Q8WXD0 Q8WXD0-2 RXFP2 Relaxin receptor 2 3 IT(1)LGDS(1)IMKPVS(1) 81.017 0.028092 31956000.0 216.41 258.17 300.28 326.6 312.81 224.77 261.56 236.65 55.732 223.5 True False 221.45193193944294 227.94333638002308 259.50362531997257 269.5654410412962 284.5163907310912 222.50901787483116 241.83031861683577 230.37327325246483 94.57313349577092 252.18840207435758 0.8781210004818064 0.9038612977642569 1.0290069772655845 1.068904988587917 1.1281898310581377 0.8823126521465667 0.9589272013608788 0.9134967007108417 0.375009844694944 1.0 7.978358118674187 -8.023339642335142 23.984790941516035 0.6730875562809442 0.9797383048347443 0.34059614760091805 0.1594196599541794 457.1724622626729 469805.10063427134 0.10010219831110212 0.03844469953446432 9.47677037497031e-09 8.023339642335142 0.30665074855380015 IT(ph)PDGITK ddPTM_A459_Selumetinib_30min_R1 2 ITPDGITK 8 0 Q14694;Q14694-3;Q14694-2;H3BQC6 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 IT(1)PDGITK;IT(1)PDGITK 148.91 0.0035078 57648000.0 18624.9 24251.0 17468.5 16402.5 16996.300000000003 17401.5 21812.0 19607.4 11864.2 19410.3 True False 19058.823932253265 21411.681646015953 15096.373647602051 13538.111288058357 15458.987665940493 17226.456709297843 20166.703279058045 19087.3480581888 20132.680873116453 21901.80107733289 0.8701943673471702 0.9776219576834627 0.689275443343604 0.6181277621989512 0.7058317994650979 0.7865315116539087 0.9207783053024543 0.8714967317433593 0.9192248985382588 1.0 14.418761893142774 -7.230453040952516 4.820031156421265 0.9179666304622336 0.7685542663671004 0.3685560535077438 0.09793140875073865 0.26758333776298754 16.26921659144598 0.04468090986611276 0.03302384540944244 5.882297143380882e-08 7.230453040952516 -0.14941236409513314 IT(ph)PDGITK ddPTM_A459_Selumetinib_30min_R2 1 ITPDGITK 8 0 Q14694;Q14694-3;Q14694-2;H3BQC6 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 IT(1)PDGITK 117.71 0.020412 11061000.0 134430.0 107910.0 120920.0 128170.0 114190.0 96188.0 129210.0 128850.0 92323.0 105600.0 True False 126958.91876592752 116186.35001466202 113140.13884774144 110713.02489441777 99844.4313284478 109437.02389227237 135218.52102475785 129224.93216773418 110790.17972015089 102551.05361824973 1.2380069661549944 1.1329610561308343 1.1032567180529416 1.07958934587402 0.9736070747758727 1.0671467530665841 1.3185483352332394 1.2601034080915345 1.080341701144989 1.0 16.645982788702312 IT(ph)PEPAVSNTEEPSTTSTASNYPDVLTRPSLHR ddPTM_A459_Selumetinib_30min_R2 3 ITPEPAVSNTEEPSTTSTASNYPDVLTRPSLHR 33 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 IT(0.962)PEPAVS(0.028)NT(0.011)EEPSTTSTASNYPDVLTRPSLHR;IT(0.859)PEPAVS(0.003)NT(0.003)EEPS(0.094)T(0.028)T(0.009)S(0.001)T(0.001)AS(0.001)NYPDVLTRPSLHR;IT(0.998)PEPAVS(0.001)NT(0.001)EEPSTTSTASNYPDVLTRPSLHR 73.175 4.5257e-05 36230900.0 37112.8 25332.2 43025.0 63575.0 63365.0 48810.0 53591.0 62543.0 61266.0 54329.0 True False 35050.219150309626 27275.098284138796 40256.81834207803 54915.97532700785 55404.52220971268 55533.13444693541 56083.08768855195 62724.98977544898 73520.91191506732 52760.380606305705 0.6643283984596685 0.5169617423282763 0.763012280795918 1.040856314831901 1.050116044900005 1.0525537118717887 1.062977314493617 1.1888653769103468 1.3934871407330296 1.0 15.687167351584874 -5.704128741845474 1.791019877745069 1.1308114867469543 0.5776277398466424 0.799102695402565 0.1094651794080177 0.15555262155866983 1.0099516036665197 0.035380307437697996 0.07837246411599426 1.9763836759571206e-06 5.704128741845474 -0.5531837469003119 IT(ph)RTPQASTYSYETSDLCYTAEK ddPTM_A459_Selumetinib_30min_R1 2 ITRTPQASTYSYETSDLCYTAEK 23 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 IT(0.591)RT(0.394)PQAS(0.006)T(0.007)Y(0.001)S(0.001)YETSDLCYTAEK;IT(0.501)RT(0.449)PQAS(0.015)T(0.015)Y(0.001)S(0.016)Y(0.002)ETSDLCYTAEK 94.006 0.00012789 26692200.0 5803.1 6213.1 8019.0 8267.0 7315.799999999999 6239.299999999999 6507.5 5674.799999999999 3560.2 4966.0 True False 5938.300939133038 5485.667363608176 6930.0638452140065 6823.323640809533 6654.087181709396 6176.538306831138 6016.634035781691 5524.285869651753 6041.399373280046 5603.434472936282 1.05976093194524 0.9789830487182632 1.2367529019363281 1.217703833919202 1.187501560667409 1.102277243833734 1.0737404113211457 0.9858749836967302 1.0781600824385593 1.0 12.45209564366771 -7.343119776531134 2.4573205288633595 1.024902128071316 1.136927141362438 0.29994709795321806 0.07485684848383033 0.4236974557950722 5.0006655367744655 0.040953774819797596 0.025483130898204878 4.5381643878721976e-08 7.343119776531134 0.11202501329112202 IT(ph)RTPQASTYSYETSDLCYTAEK ddPTM_A459_Selumetinib_30min_R2 1 ITRTPQASTYSYETSDLCYTAEK 23 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 IT(0.527)RT(0.467)PQAS(0.003)T(0.003)YS(0.001)YETSDLCYTAEK 94.192 0.0082565 0.0 19238.0 29510.0 26298.0 28096.0 28159.0 22287.0 16538.0 18423.0 16214.0 33073.0 True False 18168.82897581578 31773.322110394518 24606.01531109745 24269.276331696627 24621.414675345986 25356.831948757408 17307.0497694253 18476.607879908162 19457.253057012076 32118.096556026234 0.5656882232769429 0.9892654147474058 0.7661106338657135 0.755626233620717 0.766590094540529 0.7894873814992556 0.5388566454813158 0.575270948814725 0.6058034299470765 1.0 14.971098775189486 -7.229400337281737 24.17332566781071 0.6445886505855136 0.7807225888262009 0.059795096334457454 0.15318469384940797 803.5983930289987 606312.0844216632 0.05514849615796596 0.04271330338504835 5.896572772065035e-08 7.229400337281737 0.1361339382406873 IT(ph)VQASPNLDK ddPTM_A459_Selumetinib_30min_R2 2 ITVQASPNLDK 11 0 Q5TCX8;Q5TCX8-2 Q5TCX8 MLK4 Mitogen-activated protein kinase kinase kinase MLK4 1 IT(0.778)VQAS(0.222)PNLDK;IT(0.96)VQAS(0.04)PNLDK 157.33 0.0013071 61119000.0 503580.0 403130.0 478800.0 468480.0 455540.0 350680.0 428840.0 423600.0 323710.0 409550.0 True False 475593.03959046246 434048.7747327452 447994.52927802294 404672.2158269227 398310.9926207291 398982.98684391123 448781.9097303392 424832.60586924513 388461.0452131111 397725.22736130806 1.1957829347305053 1.0913282459159663 1.1263920376643557 1.0174668036817884 1.0014727887977015 1.003162382962096 1.128371747268245 1.0681560450358654 0.9767070793832722 1.0 18.601412548359583 -4.743122201752821 0.9355967710233551 1.03409723490944 1.2775393507938062 0.5383407043389732 0.04685901304404561 1.963541873249793 1.288965022138339 0.016993646701449237 0.4970434411114365 1.8066656950084257e-05 4.743122201752821 0.24344211588436626 ITAHS(ph)SPPLTK ddPTM_A459_Selumetinib_30min_R1 1 ITAHSSPPLTK 11 0 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 ITAHS(0.575)S(0.424)PPLTK 78.529 0.03136 23793000.0 6701.6 7940.9 8420.1 8920.4 7790.6 6835.6 7445.2 7080.6 3813.6 6262.7 True False 6857.73424095638 7011.175736375744 7276.6966682985985 7362.619596646591 7085.941605542142 6766.840070228221 6883.602569835094 6892.799486969799 6471.400665676307 7066.57854886389 0.9704461916805429 0.9921598816025256 1.02973406691538 1.0418931234876454 1.002740089357864 0.9575836486408462 0.9741068499042986 0.9754083166708689 0.9157756644078807 1.0 12.786796153818226 -6.700835067083797 5.472651931526634 0.9636313184570252 1.0102942401668553 0.38783057283436984 0.02686009957913927 0.21097033664436562 12.5041261180243 0.009329722668180907 0.009199682530155743 1.9914294847026006e-07 6.700835067083797 0.04666292170983011 ITAHS(ph)SPPLTK ddPTM_A459_Selumetinib_30min_R2 2 ITAHSSPPLTK 11 0 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 ITAHS(0.585)S(0.415)PPLTK;ITAHS(0.773)S(0.226)PPLTK 88.22399999999998 0.02047 39818000.0 455220.0 399340.0 478980.0 527820.0 506250.0 399010.0 386170.0 394910.0 325540.0 423080.0 True False 429920.69479004416 429968.0939195164 448162.9482739935 455930.0054597131 442650.3490675772 453970.00564785255 404127.6701813382 396059.12271912984 390657.0963475828 410864.58110614587 1.0463805218561177 1.0464958862161817 1.0907801959162104 1.1096843739419942 1.077363125037102 1.1049139461611817 0.983603086674762 0.9639651138894567 0.9508171653439689 1.0 18.648303441678927 -7.332266455726802 5.5579257289530455 0.9698674914985494 1.0795082687966697 0.8325938310397522 0.02299104242191661 0.0916363508485529 5.282909151218281 0.010504960046449961 0.007031780154091051 4.653005268469412e-08 7.332266455726802 0.10964077729812027 ITAHSS(ph)PPLTK ddPTM_A459_Selumetinib_30min_R2 1 ITAHSSPPLTK 11 0 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 ITAHS(0.19)S(0.809)PPLTK 93.228 0.015806 20195000.0 284460.0 250360.0 297180.0 336720.0 322390.0 235170.0 241420.0 250340.0 219110.0 254650.0 True False 268650.85198360344 269561.80696571834 278059.7623451187 290858.1551256013 281888.48599683226 267562.53283929115 252646.50836465464 251068.44795398222 262938.1224449188 247297.5928398414 1.0863464091928754 1.0900300478876719 1.124393323655196 1.1761463255081954 1.1398755756567074 1.081945561081842 1.0216294686227592 1.0152482483587415 1.0632457818350327 1.0 17.91588867124139 -7.058197636889412 3.273293493872987 1.0266001225345922 1.124144643066681 0.7309907096262686 0.028038949854467615 0.1478552161056462 3.1348785281852023 0.012454127154913569 0.00974491585466673 8.745856819131519e-08 7.058197636889412 0.09754452053208884 ITEFCHR ddPTM_A459_Selumetinib_30min_R1 2 ITEFCHR 7 0 P07237;H7BZ94;I3L398;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 ; 173.59 7.3014e-18 0.0 11351.2 13202.2 13243.1 15096.8 13074.8 11120.7 11974.3 11422.8 6580.9 9604.7 False True 11615.660874409701 11656.480286463731 11444.759759141234 12460.427282033801 11892.186648543428 11008.835854787723 11071.068910435757 11119.830237516393 11167.30665008108 10837.556802700587 1.0717970005486126 1.0755634778826793 1.0560276607998345 1.1497450494495969 1.0973125091791944 1.0158042126288516 1.0215465636754018 1.0260458551640963 1.0304265853811556 1.0 13.403751934589149 -6.762354342383017 24.995115842001002 1.0205663704954933 1.0907040775466386 0.6830667941583358 0.024274558215326057 15.75668078672574 430431.04340975825 0.008832453234915258 0.008241295944465852 1.7284055716238946e-07 6.762354342383017 0.0701377070511453 ITEFCHR ddPTM_A459_Selumetinib_30min_R2 5 ITEFCHR 7 0 P07237;H7BZ94;I3L398;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 ;;;; 167.82 5.0426e-05 44548100.0 165149.0 136307.0 167792.0 175127.0 185480.0 123423.0 135422.0 144601.0 121017.0 146419.0 False True 155970.67972382787 146761.30860391533 156996.44539811657 151274.40048907447 162178.34418776148 140423.39792755785 141719.39133360234 145021.7649700158 145223.78149749775 142191.50302775123 1.0969057672411506 1.032138387167004 1.1041197403158183 1.063877920043862 1.1405628376831312 0.9875653251949359 0.99667974749478 1.0199045785577792 1.021325314137475 1.0 17.11747573049128 -6.780019999333849 24.999863140874982 1.0058130614963585 1.084052788558952 0.6858054513365628 0.027843849982578564 148.4037811505052 199673.20199349808 0.00964396760497119 0.008520054375616736 1.659510484941327e-07 6.780019999333849 0.07823972706259341 ITES(ph)SLVEITEHK ddPTM_A459_Selumetinib_30min_R1 1 ITESSLVEITEHK 13 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 IT(0.132)ES(0.831)S(0.037)LVEITEHK 159.22 0.00024102 6562600.0 3535.1 6071.6 2772.3 2360.2 3235.8 3659.3 5692.8 5277.0 2699.8 4912.8 True False 3617.460951892818 5360.734249389735 2395.836887153857 1948.0353764411122 2943.1224613268914 3622.4907643785623 5263.387512700428 5137.036817888258 4581.363414409717 5543.405734724403 0.6525701211500197 0.9670470656350486 0.4321958380470176 0.3514149008142124 0.5309231548560304 0.6534774717439402 0.9494862480893441 0.9266932755272426 0.8264528403020611 1.0 12.436556890348074 -7.17796595921179 4.166400916985571 0.9200674025958594 0.5871819731333004 0.5114631956883879 0.15765158386198214 0.22034402206586576 7.055267476035147 0.07012487322311378 0.05287026848546857 6.637950978251029e-08 7.17796595921179 -0.33288542946255895 ITESS(ph)LVEITEHK ddPTM_A459_Selumetinib_30min_R1 1 ITESSLVEITEHK 13 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 IT(0.106)ES(0.077)S(0.817)LVEITEHK 195.54 0.00013409 7552800.0 2881.2 4848.1 2004.4 2005.1 2343.2 2625.8 4592.6 3901.5 2008.2 3740.5 True False 2948.3263541607284 4280.482198179459 1732.2134893810887 1654.9469253885572 2131.257973725561 2599.386836035645 4246.176484476527 3798.0195461419476 3407.7687268751733 4220.629610555412 0.69855131253101 1.0141809618816968 0.4104158974407467 0.3921090164485614 0.5049620957962002 0.6158765577379295 1.006052858525473 0.8998703739943076 0.8074076716783327 1.0 12.04324251304296 -7.24871448382981 22.30501464668326 0.9199885629903073 0.6013615178338488 0.4563816007772773 0.17219298223133112 189.8799327191224 332834.0462179541 0.07319030056615305 0.056179992312268445 5.640083272991738e-08 7.24871448382981 -0.31862704515645845 ITHQEVDSR ddPTM_A459_Selumetinib_30min_R2 1 ITHQEVDSR 9 0 D6RJA0;Q8WTS6 D6RJA0 SETD7 Histone-lysine N-methyltransferase SETD7 0 86.898 0.046697 997850.0 11273.0 10172.0 9511.1 8788.1 12139.0 7110.0 8701.1 9353.3 8758.5 11861.0 False True 10646.491789394497 10952.159691864894 8899.166180902697 7591.145619681919 10613.990295963096 8089.33796184615 9105.718390902559 9380.516554477828 10510.444732936983 11518.542111421008 0.9242916062127476 0.95082863663844 0.7725948383761939 0.6590370158177442 0.9214699389290751 0.7022883524317987 0.7905269870805911 0.8143840135095519 0.9124804711627122 1.0 13.491670507638453 -8.482515032577409 2.607861500990088 0.9989789193827008 0.8130854799058207 0.2985954152095659 0.09020478028495799 0.3367730683379473 5.1503508584916755 0.09016676431843515 0.02444910332627594 3.2921905761730316e-09 8.482515032577409 -0.18589343947688008 ITHS(ph)PDSVK ddPTM_A459_Selumetinib_30min_R1 2 ITHSPDSVK 9 0 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 IT(0.002)HS(0.957)PDS(0.041)VK;IT(0.029)HS(0.941)PDS(0.029)VK 150.15 0.0013502 27016000.0 10883.3 11206.900000000001 11794.8 12660.900000000001 12390.9 10083.099999999999 10936.9 10162.5 4538.9 7304.200000000001 True False 11136.85971478461 9894.790938053537 10193.130944198796 10449.91148952769 11270.145282791076 9981.673168722291 10111.92082765129 9892.957487547741 7702.181791860241 8241.765218932991 1.3512711681231837 1.2005669507938923 1.2367655075617934 1.2679215206861443 1.3674431366840307 1.211108652524144 1.226912021762301 1.2003444923208477 0.9345305996058686 1.0 13.008737651179613 -8.15154034519882 3.3410382636022895 0.9650435985270861 1.2625108115218278 0.8178694160505766 0.055349359491469755 0.10184558439104478 2.011136518189763 0.045594311844517434 0.014751949266857967 7.054393069270817e-09 8.15154034519882 0.29746721299474166 ITHS(ph)PDSVK ddPTM_A459_Selumetinib_30min_R2 2 ITHSPDSVK 9 0 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 ITHS(0.979)PDS(0.021)VK;IT(0.005)HS(0.949)PDS(0.046)VK 138.22 0.0024856 20281200.0 113965.0 98583.0 114640.0 139181.0 141416.0 113526.0 97838.0 107345.0 95060.0 119010.0 True False 107631.28153804157 106143.99910569363 107264.18721059446 120224.30769938337 123650.05780491946 129163.17601357878 102387.66086231904 107657.35617807852 114074.65619832044 115573.87207488515 0.9312769366098832 0.9184082630451154 0.9281006622421849 1.0402377764196133 1.0698789924144916 1.1175811080370186 0.8859066415632227 0.9315025467721876 0.987028072611487 1.0 16.81845575732293 -5.7406487593823075 22.542190759740222 1.004219755782765 0.9251763684875909 0.25403167161078266 0.06176564840632769 125.02363428014577 135552.38504030625 0.018895302239103472 0.03265702872658379 1.816984575701056e-06 5.7406487593823075 -0.07904338729517413 ITHS(ph)PTVSQVTER ddPTM_A459_Selumetinib_30min_R2 2 ITHSPTVSQVTER 13 0 P16157-14;H0YBS0;P16157-15;P16157-12;P16157-21;P16157;P16157-3;P16157-16;P16157-5;P16157-8;P16157-10;P16157-13;P16157-4;P16157-7;P16157-6;P16157-9;P16157-11;A0A2R8Y4B0 P16157-14 ANK1 Ankyrin-1 1 IT(0.119)HS(0.881)PTVSQVTER;IT(0.205)HS(0.795)PTVSQVTER 101.01 0.006922199999999999 11447800.0 26679.0 28262.0 33037.0 40083.0 44390.0 33055.0 25684.0 29739.0 34568.0 35353.0 True False 25196.287984498875 30429.604523346974 30911.4353879659 34623.62625296826 38813.33134836493 37608.0262065857 26878.356891880492 29825.53556644352 41482.56591062003 34332.267031874806 0.7338952583907759 0.8863266878093277 0.900361032356735 1.008486454472201 1.1305204900197767 1.0954134246849943 0.7828890782809669 0.8687318998990908 1.2082676006249962 1.0 15.067277504180986 -4.9235194036084104 1.2599395391032346 1.0036031497072961 0.6685978467959897 0.3484785180677247 0.11774312125361264 1.4361383273946589 2.3761923083964764 0.03821261274487898 0.5870658109241258 1.1925609828779832e-05 4.9235194036084104 -0.3350053029113065 ITHSPT(ph)VSQVTER ddPTM_A459_Selumetinib_30min_R1 1 ITHSPTVSQVTER 13 0 P16157-14;H0YBS0;P16157-15;P16157-12;P16157-21;P16157;P16157-3;P16157-16;P16157-5;P16157-8;P16157-10;P16157-13;P16157-4;P16157-7;P16157-6;P16157-9;P16157-11;A0A2R8Y4B0 P16157-14 ANK1 Ankyrin-1 1 IT(0.002)HS(0.228)PT(0.761)VS(0.009)QVTER 153.41 0.00096424 5965500.0 1097.4 1260.7 1246.3 1499.8 1405.1 1358.0 1373.5 1288.4 636.49 1051.7 True False 1122.9672848313137 1113.0966579164701 1077.0593054358674 1237.8880847328107 1278.008953090554 1344.3397529653464 1269.8957891888058 1254.2274466869876 1080.0770426096908 1186.695939425512 0.9462974023278028 0.9379796634808814 0.9076118571344227 1.0431383841526256 1.0769472706793346 1.1328426333169648 1.070110503456826 1.0569071697457464 0.9101548313484277 1.0 10.212734613174577 -5.772181814102748 21.507373320198838 1.0502963995703405 0.9313646607514233 0.44866404656042536 0.05568843560016223 32.87072683432176 65811.19141540684 0.016357148161110457 0.02464196944829475 1.6897333894363626e-06 5.772181814102748 -0.11893173881891717 ITKPGSIDSNNQLFAPGGRLS(ph)WGK ddPTM_A459_Selumetinib_30min_R1 2 ITKPGSIDSNNQLFAPGGRLSWGK 24 2 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 ITKPGSIDSNNQLFAPGGRLS(0.999)WGK;ITKPGSIDSNNQLFAPGGRLS(1)WGK 79.163 0.00011491 53089000.0 4926.200000000001 4528.299999999999 6456.9 7741.099999999999 5660.3 5068.1 5319.8 5113.700000000001 3028.69 4588.0 True False 5040.970875283417 3998.1245308504426 5580.0884452129085 6389.262203443899 5148.326864407133 5017.119515466617 4918.523203004447 4978.06806436142 5139.465723234523 5176.914490904482 0.9737404170264142 0.772298738539124 1.0778791990898784 1.234183453226712 0.9944778638805846 0.9691331630610057 0.9500877813697692 0.9615897796086021 0.9927661992996496 1.0 12.337876773506693 -5.272450519473251 24.990047170918572 1.0232080137649608 0.8730195712359379 0.3032551665881551 0.09063507343627393 828.5729956828847 1880468.0796261095 0.02568249889447439 0.054281292171304854 5.340101115482553e-06 5.272450519473251 -0.15018844252902297 ITLDNAYMEK ddPTM_A459_Selumetinib_30min_R2 1 ITLDNAYMEK 10 0 P14618;P14618-3;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 147.3 0.011494 18391000.0 56418.0 44100.0 48708.0 54230.0 53310.0 34927.0 43213.0 36281.0 32959.0 40770.0 False True 53282.51341914828 47482.32819615036 45574.18030926062 46843.780448032056 46612.72120255314 39737.87721426164 45222.49012493505 36386.5717033571 39551.7209514038 39592.86416681855 1.345760518730104 1.1992647967090924 1.1510705595139745 1.1831369473716997 1.1773010663274444 1.003662605636008 1.1421878936163072 0.919018425897348 0.9989608426598944 1.0 15.272952815945043 -5.369839346242297 0.3285002283832732 0.9580597772193068 1.4651183576354279 0.7330229612676895 0.06292746833915769 2.4952763609101174 0.2921726994043126 0.06822394545826616 0.4891777216371228 4.267373478384401e-06 5.369839346242297 0.5070585804161211 ITLPVDFVTADKFDENAK ddPTM_A459_Selumetinib_30min_R1 2 ITLPVDFVTADKFDENAK 18 1 P00558-2;P00558 P00558-2 PGK1 Phosphoglycerate kinase 1 0 ; 218.2 8.3727e-14 36817000.0 8164.299999999999 7242.9 8231.3 8970.8 7867.6 7973.4 7286.799999999999 7633.0 5771.3 7507.5 False True 8354.51230503763 6394.897900867143 7113.534671294433 7404.218182771764 7155.976969137597 7893.19483526796 6737.150809363659 7430.548044521718 9793.474580925551 8471.160754242683 0.9862299332300322 0.7549022012909308 0.8397355306628671 0.8740500148180339 0.8447457410784713 0.931772523773055 0.7953043278029442 0.8771581911959603 1.1560959430525035 1.0 13.048343951935381 -8.197437779606165 7.170924195851501 1.0771156485804123 0.8577858094078177 0.5978287757488218 0.07049412895213304 0.14459997395301982 14.028272850019041 0.04531395866299364 0.016789414272912202 6.3469082519518925e-09 8.197437779606165 -0.21932983917259463 ITPGNYGNT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 ITPGNYGNTPR 11 0 Q5VYS8-5;Q5VYS8-3;Q5VYS8-2;Q5VYS8-4;Q5VYS8-6;Q5VYS8 Q5VYS8-5 ZCCHC6 Terminal uridylyltransferase 7 1 ITPGNYGNT(1)PR 128.21 0.0063732 0.0 1527.0 1961.0 1933.3 1850.8 1990.7 1632.5 1695.1 1704.6 909.61 1463.8 True False 1562.576128975229 1731.4052083558342 1670.7684788567442 1527.5925238188318 1810.6415364866318 1616.0785321914045 1567.237242267161 1659.3884706788572 1543.5417347141367 1651.6929886194378 0.9460451426153376 1.0482609179100673 1.011549053225231 0.9248646899540726 1.0962337122954373 0.9784376051279351 0.9488671642162332 1.0046591479847908 0.9345209705129893 1.0 10.689729832824828 -6.976264331079821 24.99716515882106 0.9711503379197004 1.0070103118019809 0.09768824272347376 0.04892961951426351 523.6698911734053 551500.211593173 0.01662661305361041 0.014662816975709723 1.0561744784364096e-07 6.976264331079821 0.03585997388228046 ITPGNYGNT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 ITPGNYGNTPR 11 0 Q5VYS8-5;Q5VYS8-3;Q5VYS8-2;Q5VYS8-4;Q5VYS8-6;Q5VYS8 Q5VYS8-5 ZCCHC6 Terminal uridylyltransferase 7 1 ITPGNYGNT(1)PR 99.732 0.039675 7025800.0 26308.0 23945.0 27347.0 24553.0 28430.0 19932.0 31674.0 31147.0 22147.0 25462.0 True False 24845.906679268213 25781.504504689816 25587.523793162305 21208.83904371254 24858.369232575264 22677.452075318917 33146.9037608403 31237.632613336587 26577.018838882843 24726.845901779103 1.0048150410271512 1.0426523709129771 1.0348074273120809 0.8577252079767504 1.0053190500445792 0.9171186719648408 1.3405229236477498 1.2633084194166888 1.0748244618198806 1.0 14.593790604232064 -7.246258507497586 24.968819879936813 1.1916063280480516 0.9785371484750083 0.4540131415031271 0.1023332869426404 655.1338026759358 1077535.9499590495 0.03893556196787832 0.03003382347369738 5.6720688322777815e-08 7.246258507497586 -0.21306917957304328 ITPHT(ph)SPAPR ddPTM_A459_Selumetinib_30min_R1 1 ITPHTSPAPR 10 0 A0A0C4DFZ9;Q58A45-2;Q58A45-4;Q58A45-3;Q58A45 A0A0C4DFZ9 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 1 ITPHT(0.5)S(0.5)PAPR 138.2 0.0022537 19561000.0 586.11 850.89 1054.2 832.87 1055.8 830.55 1186.8 696.66 472.64 650.99 True False 599.7652226284688 751.2674032319705 911.0454303060986 687.4248894061983 960.3030764166297 822.1954210790632 1097.278720501838 678.1823137293984 802.035559740206 734.5509076795793 0.8165059989145017 1.0227574363840868 1.2402754128833078 0.9358437682389497 1.3073335916910016 1.1193171398785005 1.4938089505165861 0.9232611472385933 1.0918719878433047 1.0 9.520718669272147 -4.873328846544423 2.9617296684764836 1.1471050707589892 0.7926923602749026 0.259288202751932 0.1660997856978361 0.42553775615911615 6.083862907558943 0.041719817500894166 0.3259996566333684 1.3386626720081016e-05 4.873328846544423 -0.3544127104840865 ITPHT(ph)SPAPR ddPTM_A459_Selumetinib_30min_R2 3 ITPHTSPAPR 10 0 A0A0C4DFZ9;Q58A45-2;Q58A45-4;Q58A45-3;Q58A45 A0A0C4DFZ9 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 1 ITPHT(0.5)S(0.5)PAPR;IT(0.002)PHT(0.499)S(0.499)PAPR;ITPHT(0.5)S(0.5)PAPR 120.6 0.0068289 37615700.0 59069.0 52997.0 57824.0 63152.0 63694.0 48895.0 50873.0 61086.0 50467.0 61031.0 True False 55786.18145194213 57061.6994877864 54103.66679401093 54550.58865672359 55692.190288415324 55629.84242538219 53238.6953029371 61263.75014666827 60561.81016579675 59268.87645241847 0.9412390581881154 0.9627599324174128 0.912851230399918 0.9203918130710177 0.9396532146703583 0.9386012652026948 0.8982572049544004 1.0336580312240489 1.021814716100047 1.0 15.854987088448802 -7.769446256148119 24.999114479636926 1.0208023077857076 0.931366099327479 0.8283306935524131 0.018337243040337986 69.919325212023 218298.37432459087 0.009939553002223324 0.004907416054712233 1.700410366052265e-08 7.769446256148119 -0.08943620845822853 ITPLSLQTQGS(ph)SHETLNIVEEK ddPTM_A459_Selumetinib_30min_R2 1 ITPLSLQTQGSSHETLNIVEEK 22 0 O43491;E9PMV8;Q6R5J7 O43491 EPB41L2 Band 4.1-like protein 2 1 ITPLS(0.005)LQT(0.011)QGS(0.49)S(0.49)HET(0.004)LNIVEEK 84.324 0.0024297 0.0 11376.0 11026.0 15495.0 17273.0 16335.0 12265.0 14972.0 14241.0 12639.0 15588.0 True False 10743.767461736174 11871.658745822086 14498.068569680398 14920.387602413002 14282.85126324715 13954.392419415337 15668.227666455185 14282.438952275526 15167.15316316614 15137.93393751207 0.7097248215037407 0.7842324319043237 0.9577309974747561 0.9856290603462085 0.9435139116213204 0.9218161789460649 1.0350307863102135 0.9434866746830879 1.0019301990466258 1.0 13.88588069573817 -5.16905165966219 2.668636664912981 0.973382877934021 0.7153811252200023 0.8929970758265099 0.031906730013722163 0.0843741376435901 1.1201710930086504 0.008488176544590614 0.032050448505895716 6.7756090642675115e-06 5.16905165966219 -0.2580017527140187 ITPLSLQTQGSS(ph)HETLNIVEEK ddPTM_A459_Selumetinib_30min_R1 2 ITPLSLQTQGSSHETLNIVEEK 22 0 O43491;E9PMV8;Q6R5J7 O43491 EPB41L2 Band 4.1-like protein 2 1 ITPLSLQTQGS(0.057)S(0.943)HETLNIVEEK;ITPLSLQTQGS(0.218)S(0.78)HET(0.001)LNIVEEK 169.8 4.7781e-12 97291000.0 5510.0 5736.1 5890.3 6168.3 7341.0 5669.4 6761.9 5715.8 2074.6000000000004 4411.200000000001 True False 5638.372279406359 5064.514745359458 5090.429613101889 5091.122198331371 6677.00784615882 5612.37098340334 6251.844438963078 5564.19841646498 3520.4446772110555 4977.420488726646 1.132790024908826 1.0174978699971344 1.0227043555253563 1.022843500938337 1.3414594690726989 1.1275661753140593 1.2560410463859488 1.11788795603412 0.7072829561385273 1.0 12.281182554613697 -8.207652830916254 10.71312116557853 0.8538793221000986 1.1302695282189978 0.4671179341172893 0.11800532832107635 0.6171008691253603 121.84384714249701 0.08189669961369994 0.030859629501626365 6.199364457910675e-09 8.207652830916254 0.2763902061188992 ITPPAAKPGS(ph)PQAK ddPTM_A459_Selumetinib_30min_R1 2 ITPPAAKPGSPQAK 14 1 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 IT(0.001)PPAAKPGS(0.999)PQAK;IT(0.01)PPAAKPGS(0.99)PQAK 142.54 0.0025885 230660000.0 9252.6 9669.4 11860.4 11901.0 9552.900000000001 8992.6 10002.3 9644.3 5213.0 8424.9 True False 9468.16757757446 8537.302152817894 10249.822824513805 9822.713759438042 8688.841881701483 8902.142608627519 9247.818458102074 9388.501834898572 8846.08025754421 9506.317980475413 0.9959868370720075 0.8980661251130316 1.0782116530885504 1.0332826841698814 0.9140070739845957 0.9364448598196713 0.9728076082764895 0.9876065427414886 0.9305474817603162 1.0 13.214670944369079 -6.254744954121801 24.971753817358053 0.9560549855553199 0.9994942597675395 0.16669454049819477 0.04862981414074298 1079.5339839275 4026914.9067084664 0.01510321874116544 0.019006820640249396 5.562308161724272e-07 6.254744954121801 0.0434392742122196 ITPPAAKPGS(ph)PQAK ddPTM_A459_Selumetinib_30min_R2 2 ITPPAAKPGSPQAK 14 1 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 IT(0.002)PPAAKPGS(0.998)PQAK;ITPPAAKPGS(1)PQAK 139.0 0.0027256 433260000.0 564942.0 623460.0 625257.0 609615.0 564620.0 452980.0 491734.0 498267.0 382796.0 607651.0 True False 533544.785282011 671277.377260135 585028.6453483491 526584.3853554676 493687.38783315604 515373.88325697114 514600.6053524364 499716.8744774581 459365.896213889 590106.5367630954 0.9041499323302841 1.1375528577302076 0.9913949582009378 0.8923547741801587 0.8366072176410276 0.8733573535449134 0.8720469496494128 0.8468248415253106 0.7784457002182071 1.0 19.170615913969918 -5.754588124436641 3.377047949595093 0.8613077012615438 1.0295583004020954 0.428494582145732 0.07415198881438004 0.18638247734133992 4.439426825020268 0.019954417790174594 0.034422889937558904 1.759591581783121e-06 5.754588124436641 0.16825059914055163 ITPS(ph)YVAFTPEGER ddPTM_A459_Selumetinib_30min_R1 2 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 IT(0.002)PS(0.997)YVAFT(0.001)PEGER;IT(0.027)PS(0.973)YVAFTPEGER 157.09 0.00031595 11762000.0 1589.1399999999999 2487.8 2475.8 3127.1 2135.8 2147.76 2335.2 2200.1000000000004 1157.34 1923.6100000000001 True False 1626.163870071837 2196.5272194531576 2139.5999585959394 2581.010687937039 1942.617267106117 2126.1554844100524 2159.053983919693 2141.746201068025 1963.9214512308097 2170.5240810481196 0.7492033303249888 1.011980119747154 0.9857526932217922 1.189118660545199 0.8949991774189627 0.9795585789508301 0.994715517220667 0.9867415062420326 0.9048144032949204 1.0 11.083827713433935 -4.7591949784276855 24.992776058698453 0.9960602648036061 0.7492030104038919 0.48840464486575497 0.07519764949530287 51.47243474399748 573044.5485924829 0.01865880297447279 0.12048059717387846 1.741025057008293e-05 4.7591949784276855 -0.24685725439971418 ITPS(ph)YVAFTPEGER ddPTM_A459_Selumetinib_30min_R2 4 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 IT(0.042)PS(0.958)YVAFTPEGER;IT(0.002)PS(0.984)Y(0.005)VAFT(0.009)PEGER;IT(0.205)PS(0.795)YVAFTPEGER;IT(0.002)PS(0.998)YVAFTPEGER 159.12 0.00030060000000000004 9386800.0 22540.3 23415.8 26284.899999999998 25258.5 27430.7 19569.5 21712.0 20949.4 13533.400000000001 24759.0 True False 21287.60036197009 25211.716566336017 24593.75815083526 21818.24872665714 23984.610232430587 22265.020990766265 22721.651021511814 21010.359285640134 16240.458154790142 24044.143338392438 0.8853549100241453 1.048559568603106 1.0228585732794742 0.9074246655242192 0.9975240080245741 0.9260059997735347 0.944997320209411 0.8738244066317756 0.675443409491667 1.0 14.553397905327655 -7.821847106883587 3.3503348756973454 0.8212600098741984 0.9668056972251777 0.2550391437921605 0.08751308991541235 0.27262361466690205 6.1016032903812425 0.050563036747397636 0.022682341533211185 1.5071375596909928e-08 7.821847106883587 0.14554568735097928 ITPSYVAFTPEGER ddPTM_A459_Selumetinib_30min_R2 1 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 184.44 0.0010832 4322600.0 5505.8 2576.5 5831.7 2208.9 5425.2 2118.8 1976.9 4325.4 2538.7 5649.3 False True 5199.809677463693 2774.1092652467455 5456.494771074877 1908.0440094349626 4743.637874096632 2410.645467448612 2068.829767153034 4337.98619789148 3046.5109372046722 5486.1900303558505 0.9477997751978012 0.5056531490701587 0.994587271108608 0.34779036068336866 0.8646506679224426 0.43940247313895003 0.3770977227740767 0.7907101602184394 0.5553053977984548 1.0 12.421588879707164 -10.630765962142485 4.171304397498837 1.0000668635943437 0.6408494923216901 0.178798974538118 0.22660968069160056 34384508.781136565 10969781.808573082 20997.08115446401 0.05147201052422851 2.340097959193792e-11 10.630765962142485 -0.35921737127265363 ITQVSAPPAGS(ph)MTPK ddPTM_A459_Selumetinib_30min_R1 1 ITQVSAPPAGSMTPK 15 0 Q9UBP9-4;Q9UBP9;H0Y6R1;Q9UBP9-3 Q9UBP9-4 GULP1 PTB domain-containing engulfment adapter protein 1 1 ITQVS(0.002)APPAGS(0.636)MT(0.362)PK 95.873 0.017957 0.0 1543.9 1621.1 1757.3 1839.0 1326.8 1042.7 1400.9 1725.7 874.93 1415.0 True False 1579.869866093553 1431.3008583710562 1518.6683121579465 1517.853172305399 1206.7911742655656 1032.2113846958514 1295.22898512894 1679.9288301363986 1484.6923076411201 1596.6290332671845 0.9895034057226573 0.8964517295806547 0.9511716751450355 0.9506611371079817 0.7558369221159075 0.6464941844278227 0.8112272532577658 1.0521722924571637 0.9298918388092893 1.0 10.640813435210113 -10.526132934081268 9.387798216567873 0.9999999979097587 0.8827719561595622 0.08075392622702049 0.11350827769285443 8.67822603782245e-11 0.0 0.12260542713491926 0.02973618412456606 2.9776048687952066e-11 10.526132934081268 -0.11722804175019652 ITQVSAPPAGSMT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 ITQVSAPPAGSMTPK 15 0 Q9UBP9-4;Q9UBP9;H0Y6R1;Q9UBP9-3 Q9UBP9-4 GULP1 PTB domain-containing engulfment adapter protein 1 1 ITQVS(0.001)APPAGS(0.1)MT(0.9)PK 100.69 0.020808 0.0 29480.0 24538.0 25129.0 28624.0 25887.0 24539.0 26769.0 29325.0 20277.0 22231.0 True False 27841.61961779028 26419.98569789429 23512.227498386495 24725.36182084582 22634.8436272837 27919.024507136815 28013.8115417672 29410.330894984898 24332.966586717277 21589.13326692525 1.2896126617757226 1.2237631483969738 1.0890769540251735 1.1452688496172887 1.0484368847711216 1.293198025226377 1.2975885226798158 1.3622747393959438 1.127093259644453 1.0 14.398017704586165 -6.791842110264725 24.998865292351415 1.2437704139228192 1.1581433968531805 0.03115521545776212 0.11444734508905312 466.2745608492979 383394.55045548914 0.0399236567793375 0.03521353963995719 1.6149455709257698e-07 6.791842110264725 -0.08562701706963871 ITRT(ph)PQASTYSYETSDLCYTAEK ddPTM_A459_Selumetinib_30min_R2 1 ITRTPQASTYSYETSDLCYTAEK 23 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 IT(0.251)RT(0.745)PQAS(0.002)T(0.001)Y(0.001)SYETSDLCYTAEK 111.15 2.0603e-05 4332800.0 37563.0 52805.0 50533.0 43638.0 53325.0 34030.0 31087.0 31307.0 23330.0 53266.0 True False 35475.39883660297 56854.97370516375 47281.76179617035 37694.429120251174 46625.83676845145 38717.32360641695 32532.60709772188 31398.09818684716 27996.651894664607 51728.072178311435 0.685805547021277 1.099112557475164 0.9140445372328154 0.7287035362600601 0.901364284517078 0.7484779922390064 0.6289159005496857 0.6069837298133791 0.5412274363938707 1.0 15.65865980517935 -6.947496523550736 3.4407299125917032 0.6627044772748056 0.8738850444231651 0.20340176852585745 0.15584761002062705 0.3139520862678222 7.6450781334673765 0.05767878181659559 0.048800359156340005 1.1285049709710514e-07 6.947496523550736 0.21118056714835942 ITS(ph)FPESEGYSYETSTK ddPTM_A459_Selumetinib_30min_R1 1 ITSFPESEGYSYETSTK 17 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 ITS(1)FPESEGYSYETSTK 222.45 3.9072e-12 9453500.0 2630.1 2648.7 2689.0 2526.1 2600.1 2194.4 2439.0 2256.4 1219.3 1926.5 True False 2691.3762127162736 2338.588972652778 2323.8485696197104 2084.964055769805 2364.9214140849385 2172.326328355784 2255.0242663498357 2196.5529421798515 2069.0630458514593 2173.7850406991047 1.2381059591111676 1.0758142727399904 1.0690332880717333 0.9591399410400145 1.0879279090651774 0.999328952809956 1.0373722443248592 1.0104738513949036 0.9518250457671904 1.0 11.08599356815042 -1.522878761912977 0.8654029713445717 1.0096479091340156 90.95217833814327 0.7582429461537536 0.0387250484105754 339.3544062775891 0.8786939130541532 0.012728912024447897 60155.072978649194 0.029999998851057984 1.522878761912977 89.94253042900925 ITS(ph)PLMEPSSIEK ddPTM_A459_Selumetinib_30min_R1 3 ITSPLMEPSSIEK 13 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 1 IT(0.004)S(0.996)PLMEPSSIEK;IT(0.025)S(0.975)PLMEPSSIEK;IT(0.023)S(0.977)PLMEPSSIEK 168.61 0.00027553 50909000.0 9969.1 9805.2 10567.0 10915.0 10923.0 9169.6 9571.0 9110.4 6002.31 8133.400000000001 True False 10201.360633508162 8657.20262568619 9132.059440376159 9008.90014992574 9935.016578612285 9077.362149330664 8849.05176434369 8868.762597250177 10185.48167862271 9177.401116024967 1.1115740180185898 0.9433174507943822 0.995059420954192 0.9816395770470354 1.0825522882795677 0.9890994230905281 0.9642219679046246 0.966369725494959 1.1098437945397743 1.0 13.163869949428047 -4.740267572826001 24.814864588592677 1.002351671836841 1.111574464223777 0.2964620534437664 0.04988349851055894 1943.2036596135545 2277443.519055325 0.012246734063851614 0.5528447980403968 1.8185800694686487e-05 4.740267572826001 0.109222792386936 ITS(ph)PLMEPSSIEK ddPTM_A459_Selumetinib_30min_R2 2 ITSPLMEPSSIEK 13 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 1 IT(0.004)S(0.996)PLMEPSSIEK;IT(0.021)S(0.979)PLMEPSSIEK 162.48 0.00036333 15999700.0 131174.0 120572.0 138936.0 133996.0 132267.0 103532.0 119552.0 120637.0 92930.0 119534.0 True False 123883.87421112692 129819.48469991465 129997.00902207932 115745.51364400677 115650.43697801734 117792.59323007813 125111.40488779377 120988.03369746954 111518.59668114806 116082.74283336998 1.0672031965074689 1.118335779559094 1.1198650708028364 0.9970949240073756 0.9962758817994748 1.0147295830109953 1.0777778146350652 1.0422568483856451 0.9606819580514782 1.0 16.824793987732114 -5.760216540235441 24.9994613461734 1.01656212760059 1.1034548046137818 0.6142144529323657 0.03225409203912227 22.904834579339894 468240.05517362716 0.00941195106747914 0.015204913568682983 1.7369345732041184e-06 5.760216540235441 0.0868926770131917 ITS(ph)PSLK ddPTM_A459_Selumetinib_30min_R2 1 ITSPSLK 7 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 IT(0.005)S(0.99)PS(0.005)LK 82.426 0.041183 5191500.0 68368.0 63384.0 73930.0 77579.0 76188.0 63719.0 67750.0 71744.0 56976.0 71006.0 True False 64568.38025878848 68245.34898831738 69173.424288898 67012.60636876035 66616.58231063814 72495.71386650836 70900.50924407812 71952.76316214148 68372.79204245217 68955.87228425608 0.9363724672007471 0.9896959711711031 1.0031549452923327 0.9718187030179963 0.9660755509846253 1.0513348822223585 1.0282011799053992 1.0434609958312375 0.9915441539278876 1.0 16.073385796475513 -6.750267323190304 24.99807173025058 1.0259553645577195 0.9758901340658522 0.5271671075919302 0.023285072981900842 174.05643332515731 389459.73387032415 0.007684625096835506 0.007619691507099775 1.7771851547121144e-07 6.750267323190304 -0.050065230491867285 ITS(ph)VIPSPPPPPPLPPPQR ddPTM_A459_Selumetinib_30min_R2 1 ITSVIPSPPPPPPLPPPQR 19 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 IT(0.178)S(0.786)VIPS(0.036)PPPPPPLPPPQR 110.6 0.00064893 6429600.0 29214.0 33220.0 34798.0 37846.0 35573.0 24943.0 27512.0 24551.0 21532.0 36113.0 True False 27590.402832907916 35767.86718086429 32559.134565197717 32691.309512008494 31104.00171334504 28378.67183998996 28791.362513993776 24622.43934536314 25839.00165434711 35070.32385715766 0.7867165112385145 1.0198898455157626 0.9283956058635763 0.9321644603329313 0.8869037491650332 0.809193321270058 0.8209608394624966 0.702087595359854 0.7367768190447865 1.0 15.09796313277941 -6.703749607779664 2.2232280126318384 0.7913416932149524 0.9251865122304611 0.2063350984323994 0.09142562679762439 0.3776394227855489 3.8290124319695096 0.03369718140131774 0.03225010274839138 1.9781097894043278e-07 6.703749607779664 0.1338448190155087 ITSLSS(ph)SLDTSLDFSK ddPTM_A459_Selumetinib_30min_R1 2 ITSLSSSLDTSLDFSK 16 0 E9PR71;Q9P2Y5-2;Q9P2Y5 E9PR71 UVRAG UV radiation resistance-associated gene protein 1 ITSLS(0.004)S(0.599)S(0.393)LDT(0.004)SLDFSK;ITSLS(0.001)S(0.613)S(0.382)LDT(0.004)S(0.001)LDFSK 164.7 2.2666e-05 23744000.0 4277.4 5144.799999999999 4011.3 4553.9 4189.4 4019.8 5211.7 4744.700000000001 2653.2 3975.8 True False 4377.055097628451 4542.444424247371 3466.587492493695 3758.6468522901323 3810.469509698644 3979.364461686376 4818.577273036256 4618.8551430423395 4502.286617939054 4486.132657571502 0.9756856142541941 1.0125524078252186 0.7727340578399834 0.8378367603433325 0.8493885046550055 0.8870367341835458 1.0741049453594886 1.0295850559048525 1.0036008655116981 1.0 12.131256567054805 -7.249134462703028 23.64272009900903 1.0292881339685809 0.8853733441409818 0.5069192309666481 0.0664094124061332 324.16542085590135 622853.5664723746 0.02800041412691628 0.02150746943524434 5.6346317396023636e-08 7.249134462703028 -0.1439147898275991 ITSVIPS(ph)PPPPPPLPPPQR ddPTM_A459_Selumetinib_30min_R1 2 ITSVIPSPPPPPPLPPPQR 19 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 IT(0.011)S(0.304)VIPS(0.685)PPPPPPLPPPQR;IT(0.008)S(0.006)VIPS(0.986)PPPPPPLPPPQR 179.9 5.3557e-13 18398700.0 3887.8999999999996 4538.9 5063.5 4807.6 4337.6 3741.7000000000003 4554.5 3976.1 1984.26 3445.8 True False 3978.480505463517 4007.483477922639 4375.9045118145805 3968.042909828951 3945.264845865481 3704.061895191776 4210.950398151016 3870.640911806992 3367.1442953835926 3888.101994934321 1.0232448918899113 1.030704308463064 1.1254603190749115 1.0205603955345777 1.0147019936734263 0.9526658251295042 1.08303496246686 0.9955090984881367 0.8660123370658829 1.0 11.924850349710692 -7.365091967529912 0.7113184103520966 0.95158210895204 1.050369391864615 0.2655519955681961 0.05666471547363574 1.0032984132574627 0.9890234434871658 0.05077684186820985 0.03069654782461791 4.314277067008848e-08 7.365091967529912 0.0987872829125751 ITSVIPS(ph)PPPPPPLPPPQR ddPTM_A459_Selumetinib_30min_R2 2 ITSVIPSPPPPPPLPPPQR 19 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 IT(0.011)S(0.038)VIPS(0.951)PPPPPPLPPPQR;IT(0.001)S(0.008)VIPS(0.991)PPPPPPLPPPQR 74.786 0.024317 7062400.0 41690.6 43420.7 49263.1 46383.2 45504.7 31826.4 35756.8 32847.3 31542.5 46282.4 True False 39373.603352694976 46750.92807044412 46093.565779607794 40065.728144517045 39787.99276882049 36210.19770870609 37419.562050755034 32942.88020483676 37851.881371086914 44946.10685588328 0.876018104948307 1.0401552290245712 1.0255296621663756 0.8914170981034054 0.8852378003816451 0.8056359102427201 0.8325428978918772 0.7329417942796675 0.8421615133977337 1.0 15.455908537270174 -6.132844117100209 1.974975365212892 0.8286179884599815 0.984429714179513 0.34304014703535424 0.0771109744634362 0.3114546359798762 2.397169419792808 0.02489964553527955 0.03576105125635773 7.364713944186902e-07 6.132844117100209 0.1558117257195315 ITVGNDHFCVS(ph)TPERR ddPTM_A459_Selumetinib_30min_R2 1 ITVGNDHFCVSTPERR 16 1 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 ITVGNDHFCVS(0.5)T(0.5)PERR 71.376 0.020593 2751900.0 12972.0 13985.0 16021.0 18568.0 16192.0 12581.0 9993.9 15351.0 7381.0 19247.0 True False 12251.068171030372 15057.604531137476 14990.226302345907 16039.006368413398 14157.81620168338 14313.91855105294 10458.63615253716 15395.668868505134 8857.406242371173 18691.28910028837 0.6554426559504322 0.8055947586250307 0.8019899655885498 0.8581005987524931 0.7574553111729972 0.7658069207667493 0.5595460054371425 0.8236814906612091 0.47387883172993783 1.0 14.190078451813857 -7.0271095831601675 24.564510622262905 0.694310954854407 0.7812349060838654 0.03337474081843128 0.1415118755804293 1571.9793783538018 1424395.7052243438 0.049899601373735704 0.038772126284080166 9.394862252146782e-08 7.0271095831601675 0.0869239512294584 ITVGNDHFCVST(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 ITVGNDHFCVSTPER 15 0 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 ITVGNDHFCVS(0.229)T(0.771)PER;ITVGNDHFCVS(0.237)T(0.763)PER 96.153 0.014042 12353300.0 60283.0 62021.0 63995.0 64793.0 77701.0 64493.0 56498.0 58327.0 53128.0 52636.0 True False 56932.71219196921 66777.81127105313 59877.63137248772 55968.08162584069 67939.50572424661 73376.3253408359 59125.26894866314 58496.721913445355 63755.08452034895 51116.26191524801 1.113788646876507 1.3063907408130184 1.171400824883601 1.0949173419339058 1.3291172550311277 1.435479093962223 1.1566821738000768 1.1443857536068331 1.2472563941795356 1.0 15.641494716743614 -10.821475443680344 7.633289462765339 0.9999990059498899 1.2246067017438609 0.29589060290372693 0.10274786510850732 1.8132770819859148e-06 1.6664091972434646e-07 0.1037852041104512 0.025171497955581768 1.5084278991914238e-11 10.821475443680344 0.224607695793971 ITVNGDS(ph)SAEAEELANEI ddPTM_A459_Selumetinib_30min_R2 2 ITVNGDSSAEAEELANEI 18 0 A0A0B4J1W3;Q9BXJ9 A0A0B4J1W3 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 ITVNGDS(0.5)S(0.5)AEAEELANEI;ITVNGDS(0.772)S(0.228)AEAEELANEI 185.71 1.7819e-10 6725500.0 32938.0 29538.0 38001.8 36735.8 39331.1 28941.7 30448.4 29189.0 25510.6 35047.5 True False 31107.437821261065 31803.46962036032 35556.80556123142 31732.320667210326 34389.97559350478 32928.15646840544 31864.310932359982 29273.935157500924 30613.43282571928 34035.587610659146 0.9139679965895152 0.9344181150673074 1.0446949225021127 0.9323276868377766 1.0104122774931803 0.9674625525810847 0.9362056943709363 0.8600978332553605 0.8994536300037868 1.0 15.054756397042452 -7.446489814884169 4.164684532684876 0.9079176994489437 0.9692168181684961 0.14753012182668224 0.04894554328165733 0.3291571288782014 10.695002632954346 0.021671185914634798 0.013767622704736703 3.5769278912369783e-08 7.446489814884169 0.0612991187195524 ITVNGDSS(ph)AEAEELANEI ddPTM_A459_Selumetinib_30min_R1 2 ITVNGDSSAEAEELANEI 18 0 A0A0B4J1W3;Q9BXJ9 A0A0B4J1W3 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 ITVNGDS(0.04)S(0.96)AEAEELANEI;ITVNGDS(0.005)S(0.995)AEAEELANEI 189.44 2.1877e-10 41696000.0 4435.2 5957.299999999999 4142.2 4144.7 5119.1 4511.2 5611.6 4924.3 2580.3199999999997 4606.299999999999 True False 4538.531530603099 5259.816546526364 3579.7119914759273 3420.9059506548083 4656.0783088505095 4465.821423841879 5188.31249407492 4793.691567619321 4378.614580883651 5197.563474161578 0.8732036757540921 1.0119773568277255 0.6887288648366864 0.6581749251665727 0.8958194223114484 0.8592144080668996 0.998220131387977 0.9222959164327655 0.842435999608445 1.0 12.343619756466072 -6.78130323766572 2.442167613341445 0.9310996415862157 0.8144610319312517 0.21503582223576612 0.10304250084642153 0.5147830210363561 6.29496774441284 0.04284420813824577 0.03914250081004086 1.6546142578539175e-07 6.78130323766572 -0.11663860965496398 ITVNGDSS(ph)AEAEELANEI ddPTM_A459_Selumetinib_30min_R2 1 ITVNGDSSAEAEELANEI 18 0 A0A0B4J1W3;Q9BXJ9 A0A0B4J1W3 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 ITVNGDS(0.118)S(0.882)AEAEELANEI 130.01 0.00060251 1495200.0 22088.0 17199.0 20997.0 23241.0 20971.0 18794.0 15232.0 14355.0 14470.0 18158.0 True False 20860.43738526972 18518.10799649864 19646.07587980507 20075.53570703877 18336.4354968813 21382.702905054357 15940.318181635394 14396.770673401827 17364.404325580654 17633.731359850157 1.1829848691449603 1.050152552434937 1.1141190414489797 1.138473491364868 1.0398499967301937 1.212602283016523 0.9039673938738537 0.8164335942069247 0.9847265999025749 1.0 14.106050165878436 -7.277694553206979 24.92488538382533 0.9109846714361356 1.1162337161864253 0.6621015890850623 0.06840588091426186 447.7992415740288 686630.474536135 0.02708817264656163 0.018323577889709536 5.276008016988046e-08 7.277694553206979 0.2052490447502897 ITVQAS(ph)PGLDR ddPTM_A459_Selumetinib_30min_R1 2 ITVQASPGLDR 11 0 Q16584;Q16584-2 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 IT(0.006)VQAS(0.994)PGLDR;ITVQAS(1)PGLDR 97.203 0.019472 25591700.0 4609.9 5067.9 5007.1 5978.6 5692.4 4944.0 4445.9 4623.7 2410.63 4353.2 True False 4717.301700696074 4474.547911997209 4327.163322031556 4934.549742221349 5177.523425074844 4894.267848792835 4110.542183585373 4501.06445610573 4090.6630445508945 4911.9756237588035 0.9603674899930063 0.9109466851492921 0.8809415301455161 1.0045957309627835 1.0540613027539487 0.9963949790629422 0.8368409166574513 0.9163450311794032 0.8327938405811115 1.0 12.262087685848691 -9.955912547057345 5.574743387806837 0.9999999970833107 0.9347055501179168 0.07878675182404027 0.06881148101232716 8201152.236066031 2662982.5887048547 0.07470566728801177 0.018100290888710523 1.1068466448588126e-10 9.955912547057345 -0.06529444696539388 ITVQAS(ph)PGLDR ddPTM_A459_Selumetinib_30min_R2 1 ITVQASPGLDR 11 0 Q16584;Q16584-2 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 ITVQAS(1)PGLDR 106.55 0.011056 15388000.0 67460.0 49687.0 54598.0 72702.0 67055.0 81450.0 67936.0 59269.0 52133.0 51277.0 True False 63710.84326377656 53497.83313111393 51085.224121807696 62799.86218205463 58630.95142069417 92668.99817051605 71095.1586126301 59441.46297748882 62561.056717726104 49796.49977635403 1.2794241271959799 1.0743291872196505 1.025879817883618 1.2611300485797452 1.1774110968445055 1.860954054736998 1.4277139745149272 1.1936875733124264 1.2563344210677505 1.0 15.603756717570377 -6.560387769950332 24.99952065070568 1.3819908645921068 1.1538135681493396 0.14158082900273627 0.21877858286799207 281.81864894861667 187828.45594355115 0.07390202387741723 0.07390217690727226 2.751770623587381e-07 6.560387769950332 -0.2281772964427673 ITVQAS(ph)PNLDK ddPTM_A459_Selumetinib_30min_R1 4 ITVQASPNLDK 11 0 Q5TCX8;Q5TCX8-2 Q5TCX8 MLK4 Mitogen-activated protein kinase kinase kinase MLK4 1 IT(0.067)VQAS(0.933)PNLDK;ITVQAS(1)PNLDK;IT(0.005)VQAS(0.995)PNLDK;ITVQAS(1)PNLDK 145.1 0.0007078 92159000.0 22262.4 26657.6 28185.0 30207.5 26391.4 23249.5 24522.6 23483.5 13112.83 19986.9 True False 22781.070604910365 23536.51579921797 24357.63180912293 24932.327190002907 24004.30252978012 23015.63113885699 22672.840538741468 22860.641294841564 22251.51478678945 22552.413303892507 1.0101389282795021 1.0436362389277254 1.0800454692322814 1.105528124819335 1.0643784417358573 1.020539612711183 1.0053398823986688 1.0136671843849128 0.9866578129334335 1.0 14.460994202177211 -6.880050965009459 3.4069716265196006 1.0034450563734345 1.0634678780889562 0.5812394438675745 0.023886133689800772 0.19538975523087737 4.439441399486138 0.00990640048014067 0.00866734416372499 1.318102048529288e-07 6.880050965009459 0.060022821715521646 ITVQAS(ph)PNLDK ddPTM_A459_Selumetinib_30min_R2 2 ITVQASPNLDK 11 0 Q5TCX8;Q5TCX8-2 Q5TCX8 MLK4 Mitogen-activated protein kinase kinase kinase MLK4 1 ITVQAS(1)PNLDK;IT(0.001)VQAS(0.999)PNLDK 130.47 0.0023882 17597700.0 170951.0 137254.0 150593.0 176981.0 164786.0 124425.0 145986.0 145594.0 116728.0 139112.0 True False 161450.2277910741 147780.9404588308 140904.01033326093 152875.8824907463 144084.10947446869 141563.4143323077 152774.63826577106 146017.65443561584 140076.861652825 135095.47510361666 1.195082423502665 1.0939000017986134 1.0429957792826827 1.1316136411933284 1.0665354214414497 1.0478768013786561 1.1308642139834417 1.080847854627418 1.0368730821323784 1.0 17.043619828190735 -1.5228787770381158 0.02830275727670956 0.6370873002319793 1.7166501604030904 0.4433043341076819 0.04049775583604635 1664.2740309274654 3.629046946931767 45.31815480371007 104.35834810611814 0.029999997806250477 1.5228787770381158 1.079562860171111 ITVTSEVPFS(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 ITVTSEVPFSKR 12 1 K7ERI7;P35268;K7EP65;K7EKS7;K7ELC4;K7EMH1 K7ERI7 RPL22 60S ribosomal protein L22 1 ITVTSEVPFS(1)KR 68.751 0.035082 5095600.0 40357.0 29578.0 28690.0 26594.0 19464.0 22256.0 18663.0 20320.0 11486.0 22435.0 True False 38114.119501871166 31846.53749174002 26844.116635310154 22971.85132279116 17018.75830963224 25321.561980147384 19530.866480032928 20379.127835842923 13783.520945654423 21787.243256869602 1.7493777919725404 1.46170569246748 1.2321024885443503 1.0543716362806959 0.7811340842429049 1.1622196384190735 0.8964358753315324 0.9353697296888308 0.6326418070954629 1.0 14.41119604313284 -4.774495148054075 0.708521060013966 0.8833367565830935 2.321629735110567 0.8236667543822394 0.13103079834424838 1.1989945236095123 0.45267165296161566 0.05596712756221477 1.3941982780742517 1.6807567030485906e-05 4.774495148054075 1.4382929785274734 IVAHAVEVPAVQS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 IVAHAVEVPAVQSPR 15 0 Q96FF9;B5MBX0;H0YCL8 Q96FF9 CDCA5 Sororin 1 IVAHAVEVPAVQS(1)PR 132.15 0.00082948 0.0 1122.9 1393.2 1594.7 1483.4 1332.5 1197.4 1219.0 1317.3 707.6 1139.2 True False 1149.0613852169508 1230.083496318892 1378.14849906008 1224.3520368666834 1211.9756102719823 1185.355243152213 1127.0498485774701 1282.3609248065584 1200.7455189407794 1285.4274167476867 0.8939138610597235 0.9569451221378001 1.0721324915777748 0.9524863254935603 0.9428580676600568 0.9221487170013298 0.8767899563159044 0.997614418440765 0.9341216028975292 1.0 10.328032433569904 -3.629973710190213 13.346765522547479 0.9546668551781491 0.3369663222936343 0.0 0.05392812808685338 0.0 0.0 0.01273383800808074 0.0 0.00023443707263908864 3.629973710190213 -0.6177005328845148 IVAHAVEVPAVQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 IVAHAVEVPAVQSPR 15 0 Q96FF9;B5MBX0;H0YCL8 Q96FF9 CDCA5 Sororin 1 IVAHAVEVPAVQS(1)PR;IVAHAVEVPAVQS(1)PR;IVAHAVEVPAVQS(1)PR;IVAHAVEVPAVQS(1)PR;IVAHAVEVPAVQS(1)PR 152.9 0.00014422 85468400.0 135899.0 131056.0 163617.0 185773.0 194377.0 151643.0 129456.0 150146.0 156009.0 173928.0 True False 128346.27762680063 141107.5737885413 153090.06035272015 160470.39692370003 169957.62350757243 172530.4467719036 135475.96051219737 150582.9000019916 187215.15925566776 168906.2467207852 0.7598669683245448 0.8354195095093363 0.9063611519696463 0.9500560224333783 1.0062246175449345 1.0214568739847112 0.8020778576422303 0.891517649142465 1.1083968940778643 1.0 17.36586315927503 -5.129085775328776 1.4528698872971628 0.961241532032655 0.7413766903004211 0.447821702226462 0.07706713175880443 0.6789071018011751 2.037076668100659 0.024005686953198057 0.1796860076054012 7.428724023977588e-06 5.129085775328776 -0.21986484173223397 IVALMDTYS(ph)PSLPK ddPTM_A459_Selumetinib_30min_R2 1 IVALMDTYSPSLPK 14 0 K7ERF3;K7ELU8;D3DUE4;F6WF08;Q6ZW76-2;Q6ZW76;K7EJY2;K7EQE0;K7EM53;K7EJS9 K7ERF3 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 1 IVALMDT(0.009)YS(0.708)PS(0.283)LPK 92.151 0.016071000000000002 2230800.0 20851.0 22474.0 17851.0 22015.0 21379.0 18234.0 15970.0 19516.0 11286.0 22773.0 True False 19692.184893166388 24197.683534700314 16702.486094699256 19016.519022006734 18693.17888931503 20745.567988228235 16712.636643954655 19572.78832895227 13543.515357187514 22115.48431864014 0.8904252156290665 1.0941511922623905 0.7552394446375061 0.8598735052787685 0.8452529738884983 0.9380562364959258 0.7556984239259156 0.8850264388040217 0.6123996726480142 1.0 14.432769216470593 -5.267306471128697 24.997769756013117 0.8299481311860961 0.9922882054019663 0.25028000131947914 0.111329366730883 552.3063438476925 2353205.645171042 0.027159227569915182 0.05899776581725344 5.4037286028813545e-06 5.267306471128697 0.16234007421587016 IVALMDTYSPS(ph)LPK ddPTM_A459_Selumetinib_30min_R1 2 IVALMDTYSPSLPK 14 0 K7ERF3;K7ELU8;D3DUE4;F6WF08;Q6ZW76-2;Q6ZW76;K7EJY2;K7EQE0;K7EM53;K7EJS9 K7ERF3 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 1 IVALMDT(0.021)Y(0.001)S(0.484)PS(0.494)LPK;IVALMDTYS(0.385)PS(0.615)LPK 137.95 0.00058281 17255700.0 4571.6 6341.5 5211.9 6096.200000000001 5481.1 5340.3 5261.4 4487.4 2589.03 4088.8 True False 4678.109385214902 5599.034231916634 4504.15260691743 5031.613109846754 4985.335472766803 5286.581430604448 4864.5283620225555 4368.379574870531 4393.3948147304245 4613.637308284709 1.013974240414265 1.2135835259226917 0.9762693306709052 1.0905957216904514 1.0805651028993186 1.145859779898895 1.054380315784104 0.9468406992084598 0.9522627205309798 1.0 12.171688878603716 -7.650307770875031 4.51626983742671 0.9626135228448697 1.088279679954486 0.42443265773037875 0.06252065739192829 0.19100172902522658 6.635379588554267 0.029810153758755276 0.016412843154161395 2.2371351891512442e-08 7.650307770875031 0.12566615710961637 IVDS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 IVDSPEK 7 0 E9PQC4;Q9BZD4 E9PQC4 NUF2 Kinetochore protein Nuf2 1 IVDS(1)PEK 101.46 0.019909 9039700.0 3657.2 5017.9 3050.7 2873.2 2506.5 3035.1 3550.4 3026.4 1982.6 3504.7 True False 3742.405644327577 4430.401935241576 2636.4316962955927 2371.4495566437604 2279.7875175585164 3004.5696496503097 3282.5904695565623 2946.1300408673546 3364.3273966251986 3954.5623836689056 0.9463513990277487 1.120326727816392 0.6666810232108674 0.5996743322186795 0.5764955250101299 0.7597729807116544 0.8300767951246957 0.7449952118681809 0.8507458146364839 1.0 11.949302337933561 -5.263554307962947 24.975180858531978 0.73558356408488 1.0333390736173678 0.4394849170565127 0.12507705289826634 147.5545365064449 1742496.128112318 0.03305922842788652 0.07469139034867169 5.4506173216287e-06 5.263554307962947 0.29775550953248775 IVDS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 IVDSPEK 7 0 E9PQC4;Q9BZD4 E9PQC4 NUF2 Kinetochore protein Nuf2 1 IVDS(1)PEK 106.88 0.019464 0.0 162570.0 129240.0 133780.0 148570.0 126590.0 113470.0 170560.0 149170.0 128570.0 120770.0 True False 153535.0102192731 139152.292427902 125172.74044865053 128334.50970245457 110686.63247104124 129099.46252189626 178491.37795822835 149604.060003577 154287.5925459507 117283.05630185588 1.3090979640240121 1.186465435124409 1.067270451466482 1.0942289001418513 0.9437563784675157 1.1007511791782443 1.521885458875136 1.2755811855596202 1.3155147675283532 1.0 16.839635078980237 IVEDEPNKICEADR ddPTM_A459_Selumetinib_30min_R1 1 IVEDEPNKICEADR 14 1 P55060-4;P55060-3;P55060;P55060-2 P55060-4 CSE1L Exportin-2 0 108.72 0.01352 4834900.0 1188.6 1213.8 1114.3 1319.9 1117.5 1138.0 1229.1 1233.8 635.7 1221.3 False True 1216.2920673870055 1071.6877317196888 962.9841804117683 1089.4042425915693 1016.4223223106493 1126.552753221328 1136.3879974459126 1201.0756160527822 1078.7364703090077 1378.0657514694078 0.8826081528331244 0.7776753254167783 0.6987940737841826 0.7905313962196334 0.7375717168987442 0.8174883905358682 0.8246253825219889 0.8715662621845843 0.7827902762685812 1.0 10.428429009464672 -9.90253582248158 0.3782100002489265 1.0530625003802758 0.7753451902575157 0.578488581793769 0.052145449487479026 5.243674004766077 0.7957383680807667 0.4252152201657126 0.039915865188397015 1.25159603173621e-10 9.90253582248158 -0.27771731012276013 IVEGQGQSSEVIT(ph)PPEEISR ddPTM_A459_Selumetinib_30min_R1 1 IVEGQGQSSEVITPPEEISR 20 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 IVEGQGQSS(0.001)EVIT(0.999)PPEEISR 131.31 0.00036764 5034200.0 1805.6 1608.6 1577.7 1855.4 1536.1 1642.3 1400.3 1621.0 712.68 1233.3 True False 1847.6669669139976 1420.2643641821487 1363.4570056857626 1531.389220171527 1397.160026220482 1625.7799530890923 1294.6742436120014 1578.0058142499267 1209.3659079122585 1391.6060683593064 1.3277227003561316 1.0205936841426901 0.9797722478267638 1.1004473571870983 1.0039910417088966 1.1682759870441461 0.9303453563826529 1.1339457696605078 0.8690432841659653 1.0 10.4425351598886 -4.760430349301907 24.975227079216015 1.0292506682833005 1.3277230569511143 0.5266449372261782 0.0865005501907403 18.59171216858033 459948.26581508695 0.01960693549551989 0.11616920468779646 1.7360796672031123e-05 4.760430349301907 0.2984723886678138 IVEGQGQSSEVIT(ph)PPEEISR ddPTM_A459_Selumetinib_30min_R2 1 IVEGQGQSSEVITPPEEISR 20 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 IVEGQGQSSEVIT(0.999)PPEEIS(0.001)R 210.66 4.0016999999999996e-32 0.0 6132.2 6102.4 7713.1 8500.9 7773.1 5099.3 5834.5 6550.7 5287.4 5525.2 True False 5791.396873141572 6570.434457691337 7216.8475433883095 7343.062755129552 6796.573685604311 5801.682288163439 6105.815810842422 6569.761452473234 6345.027742299597 5365.673119806373 1.0793420962905325 1.224531258424561 1.345003205049647 1.3685259223160684 1.2666768052858155 1.0812589881309804 1.1379403244494997 1.224405830504694 1.1825222298537197 1.0 12.38954345204495 -6.743659375774185 24.411360907929165 1.1400455287654296 1.2661277380839386 0.32860272595959783 0.09236890752361909 247.11915036169017 339285.45135831396 0.03225232559141035 0.03218047369169718 1.8044324317092212e-07 6.743659375774185 0.126082209318509 IVEMS(ph)TSK ddPTM_A459_Selumetinib_30min_R1 2 IVEMSTSK 8 0 P63241;P63241-2;I3L397;I3L504;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 P63241 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-2 1 IVEMS(0.579)T(0.413)S(0.007)K;IVEMS(0.46)T(0.46)S(0.079)K 102.06 0.014665 10701000.0 8446.9 14970.6 16048.6 18203.7 13581.199999999999 13621.9 14627.5 13257.5 5803.7 11555.3 True False 8643.696335193752 13217.835192356872 13869.288268649641 15024.765520769883 12352.782857955612 13484.876053695622 13524.13589833219 12905.8680335709 9848.455014523179 13038.535313153576 0.6629346109508014 1.0137515353448032 1.063715205392586 1.1523353781626493 0.9474057140063761 1.0342324294732528 1.037243491965599 0.9898249859822186 0.7553344588166916 1.0 13.670494192743215 -10.53352628828214 15.058720942486039 0.9999642966739065 0.976730753566148 0.0 0.13973468007441384 0.0 0.0 0.13541555955833323 0.03284309737712513 2.927343670947442e-11 10.53352628828214 -0.023233543107758492 IVENIQVFDFK ddPTM_A459_Selumetinib_30min_R1 2 IVENIQVFDFK 11 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 0 ; 181.68 0.00056448 37959000.0 6527.0 9155.4 7703.400000000001 8792.4 7294.200000000001 7605.7 7981.3 7151.8 4796.0 5554.8 False True 6679.06640066884 8083.48151177001 6657.320591747294 7256.972393789008 6634.440897895607 7529.193563423067 7379.2641152185015 6962.1110316795975 8138.461714019188 6267.812688333964 1.0656135932556388 1.2896814109993235 1.06214415184077 1.157815773163759 1.0584938044246335 1.2012473789200597 1.1773268414598985 1.1107720313081315 1.2984532433726028 1.0 12.613746350616553 IVEPEVVGES(ph)DSEVEGDAWR ddPTM_A459_Selumetinib_30min_R1 2 IVEPEVVGESDSEVEGDAWR 20 0 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 IVEPEVVGES(0.981)DS(0.019)EVEGDAWR;IVEPEVVGES(0.917)DS(0.083)EVEGDAWR 223.86 8.763299999999997e-32 7261500.0 1240.16 1331.8400000000001 747.8 1183.37 1219.85 888.4200000000001 943.14 1037.26 452.97 843.37 True False 1269.0533150687106 1175.9075536443816 646.2528673713721 976.7166441060575 1109.5147828820088 879.4833014208198 871.9981904736298 1009.748495304676 768.6570063801652 951.6247546194667 1.3335648415074874 1.2356840739337436 0.6791047250865118 1.0263674198940154 1.1659162684620146 0.92419128143898 0.9163256695884527 1.0610784244557108 0.8077312014519146 1.0 9.894248990859161 -5.050732619991903 11.343498785231468 0.9582672298890709 1.3092408111942253 0.5298686997896631 0.12813006992995077 0.656467474006995 146.47328815957667 0.032368917156491296 0.08617257796562251 8.897487366181324e-06 5.050732619991903 0.35097358130515444 IVEPEVVGES(ph)DSEVEGDAWR ddPTM_A459_Selumetinib_30min_R2 3 IVEPEVVGESDSEVEGDAWR 20 0 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 IVEPEVVGES(0.681)DS(0.319)EVEGDAWR;IVEPEVVGES(0.842)DS(0.158)EVEGDAWR;IVEPEVVGES(0.824)DS(0.176)EVEGDAWR 217.67 2.2243e-19 6605100.0 25303.600000000002 20751.699999999997 32739.5 28423.73 31131.1 17815.390000000003 24052.0 26003.21 21209.45 26352.3 True False 23897.327210336436 22343.288662767663 30633.07621407238 24552.368940330856 27220.13290243488 20269.298260491454 25170.465658133853 26078.87503603685 25451.932641547108 25591.44062750188 0.9338015611616306 0.8730766269858373 1.1970047587376733 0.9593976868166466 1.0636420707469951 0.7920342803487593 0.9835501652487814 1.019046774881878 0.994548646635983 1.0 14.64337374332587 -7.533622467100763 23.389037111111595 1.0043383650354165 0.9718990413699963 0.02262100355158858 0.10156045906867314 593.9655984729179 1293020.4555030994 0.048812142181854305 0.02822659867315542 2.926695453449502e-08 7.533622467100763 -0.03243932366542024 IVEPEVVGESDS(ph)EVEGDAWR ddPTM_A459_Selumetinib_30min_R1 1 IVEPEVVGESDSEVEGDAWR 20 0 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 IVEPEVVGES(0.335)DS(0.665)EVEGDAWR 280.01 6.6614e-72 7372100.0 1505.3 1712.1 1741.0 1832.1 1758.2 1475.0 1753.2 1298.3 814.55 1206.1 True False 1540.3705611960784 1511.646536066303 1504.581762628455 1512.1581277763573 1599.1711204354224 1460.1628391928461 1620.954712490582 1263.8648665272553 1382.2318576218365 1360.9146834088708 1.1318641645762095 1.1107577532192343 1.1055665582648586 1.1111336707666686 1.175070810779819 1.0729275368940652 1.191077392471329 0.9286878023547211 1.0156638578985493 1.0 10.410360910886059 -7.764966731515507 24.999998946565576 0.9791318591676864 1.1257942323912957 0.7549657481802686 0.038323225446036786 40.924124858728035 290038.9786434862 0.01846233626993461 0.00942784461521808 1.718039990021557e-08 7.764966731515507 0.1466623732236093 IVEYS(ph)PPSAPR ddPTM_A459_Selumetinib_30min_R1 1 IVEYSPPSAPR 11 0 O95696;O95696-2 O95696 BRD1 Bromodomain-containing protein 1 1 IVEYS(1)PPSAPR 146.5 0.000683 21231000.0 2490.0 2803.0 3118.4 3196.4 2695.9 2360.9 2200.8 2693.0 1372.6 2096.5 True False 2548.0121553034187 2474.8234569206543 2694.9384081450744 2638.2087438591525 2452.056320999803 2337.15148952569 2034.7918841257547 2621.5728919031817 2329.2019492624554 2365.6061966393304 1.0771074910622154 1.046168825748124 1.1392168366711273 1.1152358104265585 1.0365445966802451 0.9879714945141486 0.860156642731346 1.1082034260932725 0.9846110280618168 1.0 11.207994212337258 -6.519903297881769 3.470015864482794 0.9876398683424454 1.0935860042615537 0.40882501857687614 0.06010109290059733 0.25395369003103546 6.498406562443015 0.020833491551863006 0.022173670744953907 3.020624232386275e-07 6.519903297881769 0.10594613591910829 IVEYS(ph)PPSAPR ddPTM_A459_Selumetinib_30min_R2 3 IVEYSPPSAPR 11 0 O95696;O95696-2 O95696 BRD1 Bromodomain-containing protein 1 1 IVEYS(0.684)PPS(0.316)APR;IVEYS(0.987)PPS(0.013)APR;IVEYS(0.993)PPS(0.006)APR 114.87 0.0063424 36738800.0 78242.0 67409.0 77753.0 81324.0 88360.0 64772.0 67778.0 65268.0 53299.0 72495.0 True False 73893.62286754229 72579.05354590237 72750.45663106554 70247.53090827506 77259.42685157752 73693.75505832609 70929.8112995591 65457.919074300946 63960.28929848816 70401.88098536951 1.049597281113816 1.0309249203296897 1.033359558193965 0.997807585892108 1.0974057194243587 1.046758325585657 1.0074988097874726 0.9297751446144459 0.908502562762208 1.0 16.10332635460538 -7.609781352705052 3.5713535361664306 0.9394917833075228 1.0414837550588594 0.6450866836651462 0.031823546903807 0.13999932290388128 3.505011392180947 0.016468745229384494 0.008920080576552003 2.455945059857062e-08 7.609781352705052 0.10199197175133656 IVGCSVHK ddPTM_A459_Selumetinib_30min_R2 1 IVGCSVHK 8 0 B4DY08;G3V4W0;G3V5X6;G3V3K6;G3V251;B4DSU6;G3V4M8;G3V2H6;E5RG71;B3KT61;Q86SE5;Q86SE5-3;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V576;G3V555;G3V575 B4DY08;G3V2Q1 HNRNPC;RALYL RNA-binding Raly-like protein;Heterogeneous nuclear ribonucleoproteins C1/C2 0 100.02 0.025547 4254700.0 45288.0 26219.0 48526.0 77662.0 79144.0 50532.0 44737.0 54404.0 55305.0 57763.0 False True 42771.07426222818 28229.91299262737 45403.88999111396 67084.30162557757 69201.2231636629 57492.324316175735 46817.35914468378 54562.30663293295 66367.5453508111 56095.23210370223 0.7624725428207175 0.5032497760315752 0.8094072934251635 1.1959002416027098 1.2336382357012423 1.0249057212187076 0.8346049635400989 0.9726728027805397 1.1831227514687634 1.0 15.775590531619432 -5.555046077436525 5.218255640293697 1.0569094757986215 0.635803079485539 0.6574243227668658 0.12711698493591073 0.11045415107073028 7.79160525713909 0.037451063190989106 0.06845443008370787 2.7858255846040706e-06 5.555046077436525 -0.42110639631308244 IVGPS(ph)GAAVPCK ddPTM_A459_Selumetinib_30min_R2 1 IVGPSGAAVPCK 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 IVGPS(1)GAAVPCK 107.65 0.0083935 2703100.0 25365.0 23368.0 27456.0 27528.0 33976.0 19681.0 18999.0 25007.0 21279.0 19997.0 True False 23955.314844140106 25160.25046003724 25689.510851832525 23778.638911551294 29707.631130706184 22391.879103670053 19882.491145804295 25079.7662298683 25535.39458493649 19419.634651554345 1.2335615614798772 1.2956088469987472 1.3228627269656867 1.2244637624862862 1.529772916110365 1.1530535720906474 1.0238344594301059 1.2914643699468835 1.3149266215928856 1.0 14.245228438630507 IVGS(ph)EIDSTGK ddPTM_A459_Selumetinib_30min_R1 1 IVGSEIDSTGK 11 0 Q6JVE9-2;Q6JVE9 Q6JVE9-2 LCN8 Epididymal-specific lipocalin-8 1 IVGS(1)EIDSTGK 82.029 0.040765 28978000.0 2188.2 2744.3 2632.5 2660.2 2284.7 2235.8 2437.6 2009.3 1182.3 1977.1 True False 2239.1808025039913 2422.996080209542 2275.0209592874253 2195.646008138565 2078.0492883965453 2213.309881943977 2253.7298694769815 1956.006836873769 2006.276748224539 2230.8800435848425 1.0037208450284087 1.0861167041128688 1.0197863241591654 0.9842062169377519 0.9314930645294981 0.992124111876212 1.0102425166058777 0.876787096867219 0.8993207653606582 1.0 11.123397225327064 -5.815116315986565 2.373164909405592 0.9505610938313894 1.0460455812925342 0.4220763771055721 0.04458711983163405 0.2826159751868781 3.2451789974719456 0.014119198951628066 0.025042679770915816 1.530677449329854e-06 5.815116315986565 0.0954844874611448 IVLDNSVFSEHR ddPTM_A459_Selumetinib_30min_R2 1 IVLDNSVFSEHR 12 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 88.101 0.038793 2669500.0 16175.0 16709.0 26094.0 25504.0 29150.0 26663.0 15070.0 19009.0 20488.0 26699.0 False True 15276.058253655292 17990.526572096973 24415.140448999067 22030.311203146033 25487.91639569357 30335.586227384523 15770.784860638501 19064.313042890644 24586.172482549857 25928.13049766712 0.5891692906679004 0.6938613091952645 0.9416467743864455 0.8496683247227642 0.9830217569287089 1.1699874092393188 0.608249980154083 0.73527526578154 0.9482431633380585 1.0 14.662230566497392 -5.097737089954304 3.5018730109405527 0.8946384629149363 0.6033807974647736 0.3516474873815377 0.14507475157918417 0.28766181323237683 6.37294638354838 0.03999249280049095 0.13957380629036525 7.984779177604326e-06 5.097737089954304 -0.29125766545016274 IVLEDGTLHVTEGSGR ddPTM_A459_Selumetinib_30min_R1 1 IVLEDGTLHVTEGSGR 16 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 0 143.93 0.0005487000000000001 5756300.0 907.69 906.55 1328.2 1288.0 1146.3 873.82 964.88 907.74 636.02 707.7 False True 928.8374109427153 800.4107045563386 1147.8377352803636 1063.0749787544073 1042.6173673957023 865.0301641650799 892.0983247706557 883.6637864449283 1079.2794869371326 798.5401885817578 1.1631692734117378 1.0023424193313337 1.4374201219840588 1.3312729828194056 1.305654220418682 1.083264407394963 1.1171614622866524 1.106599015403788 1.351565647377097 1.0 9.641221206564126 -6.762050315988875 24.999981980217257 1.1374707545324565 1.249478476705805 0.15535743255177725 0.135178528223034 36.27133557220206 1484203.0191866932 0.048487164474523045 0.04535393219086887 1.7296159597567443e-07 6.762050315988875 0.11200772217334842 IVLEDGTLHVTEGSGR ddPTM_A459_Selumetinib_30min_R2 1 IVLEDGTLHVTEGSGR 16 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 0 133.23 0.00077674 1441600.0 7151.4 6983.3 9288.9 8125.9 8487.2 5474.5 6238.2 6457.5 5126.1 6118.1 False True 6753.953817322435 7518.8966551513995 8691.262286989622 7019.138402040632 7420.962059469321 6228.562682436955 6528.288660758797 6476.290255903329 6151.463235201035 5941.454556267171 1.1367509005346548 1.2654976292329476 1.4628172621167146 1.1813838405339139 1.2490143598997208 1.048322868323033 1.0987694341400998 1.0900176370232442 1.0353463410255899 1.0 12.536600452089258 -6.726512273052243 5.269674586210759 1.0623362631046833 1.2685000982813812 0.5981749068075837 0.08359353648047707 0.14009172893685254 9.62322876814292 0.02940845090810862 0.02855059317805686 1.8771013712153713e-07 6.726512273052243 0.2061638351766979 IVLLDS(ph)SLEYK ddPTM_A459_Selumetinib_30min_R1 1 IVLLDSSLEYK 11 0 B4DUR8;P49368-2;P49368;Q5SZX6 B4DUR8 CCT3 T-complex protein 1 subunit gamma 1 IVLLDS(0.686)S(0.314)LEYK 130.56 0.0023701 5373200.0 2055.9 2601.8 2767.2 3137.0 2601.2 2527.6 2326.1 2542.8 1486.8 2086.6 True False 2103.7984699149793 2297.180046455996 2391.4294391415633 2589.1818387830535 2365.921919279161 2502.1746388771794 2150.640404246147 2475.356683821541 2522.9910084244634 2354.4354352051637 0.8935468938572342 0.9756819032312184 1.0157124733102634 1.0997039035633756 1.0048786574914068 1.0627493119849099 0.9134420813109883 1.0513589146715507 1.0715906542600144 1.0 11.201165445360056 -4.864618036328482 2.124499408989605 1.0281719244689538 0.8709985372276968 0.42362850038961486 0.04833953780435166 0.5470115158292783 3.269411035347061 0.01308364946018855 0.15656982913927245 1.3657838206452601e-05 4.864618036328482 -0.15717338724125696 IVNHWAS(ph)PELR ddPTM_A459_Selumetinib_30min_R1 1 IVNHWASPELR 11 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 IVNHWAS(1)PELR 116.79 0.0038282 11580000.0 4832.7 6190.5 6788.0 7264.3 6575.8 5012.3 6307.0 5585.7 3671.9 4979.0 True False 4945.292507202743 5465.713382114627 5866.22688381502 5995.726372799408 5981.020051051782 4961.880812804272 5831.257912205171 5437.549091089341 6230.946115034835 5618.103149567009 0.8802423835140657 0.9728752279202766 1.0441650371384041 1.067215430756465 1.0645977640180464 0.8831950358879914 1.0379406993719207 0.9678620962145235 1.109083608675832 1.0 12.455867397556919 -4.847956583164274 2.9504405624603773 1.0191469724737463 0.8672368511172011 0.3467432972266453 0.059206261065133936 0.39134110511751163 5.364767095514252 0.015253388834381196 0.13227927372027903 1.419199393321428e-05 4.847956583164274 -0.15191012135654525 IVNHWAS(ph)PELR ddPTM_A459_Selumetinib_30min_R2 4 IVNHWASPELR 11 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 IVNHWAS(1)PELR;IVNHWAS(1)PELR;IVNHWAS(1)PELR;IVNHWAS(1)PELR 118.52 0.0034967 33191400.0 131741.6 105554.0 132717.0 143233.0 147324.0 111875.2 113955.0 126855.0 105165.3 125194.1 True False 124419.92927540984 113649.65239039589 124178.13271134415 123724.41830929319 128815.84202672925 127284.99329804926 119254.13329754872 127224.12704802425 126201.29856399387 121579.42103966417 1.0233633966295905 0.9347770487681359 1.0213746014700316 1.017642765949093 1.0595201138908554 1.046928766477048 0.9808743311801357 1.0464281369337871 1.0380152947333239 1.0 16.891539528246867 -5.481945583550675 18.957766655914465 1.0284999574025344 0.9788208401785379 0.28890339512320373 0.029725500387611604 34.07602001714317 15780.236557733338 0.007507307738590462 0.015612337194576695 3.296510143691342e-06 5.481945583550675 -0.04967911722399654 IVPQSQVPNPES(ph)PGK ddPTM_A459_Selumetinib_30min_R1 2 IVPQSQVPNPESPGK 15 0 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 IVPQSQVPNPES(1)PGK;IVPQSQVPNPES(1)PGK 146.86 0.0003353 14323700.0 4830.4 6687.299999999999 5552.1 5580.200000000001 4700.5 5216.1 5689.1 5306.799999999999 3590.46 5500.6 True False 4942.938921677767 5904.347807158572 4798.15531550227 4605.722823327131 4275.340604940679 5163.630769839866 5259.966606679313 5166.046425084216 6092.748383177093 6206.655590381257 0.7963932990478914 0.9512929662649262 0.7730661457900443 0.7420619295301054 0.688831616751278 0.8319505883075234 0.8474719645844259 0.8323397923175049 0.9816475708140321 1.0 12.599600377119797 -8.221104009037186 1.7425162328593848 1.0084856039201289 0.800742870748996 0.5569094568418456 0.06550889697209886 0.2926636597273072 1.6289511700703887 0.06645609215110354 0.020021549378937905 6.010297798290255e-09 8.221104009037186 -0.2077427331711329 IVPQSQVPNPES(ph)PGK ddPTM_A459_Selumetinib_30min_R2 3 IVPQSQVPNPESPGK 15 0 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 IVPQSQVPNPES(1)PGK;IVPQSQVPNPES(1)PGK;IVPQSQVPNPES(1)PGK 235.02 1.3728999999999999e-14 41967400.0 117932.0 111737.0 110778.0 111366.0 99122.0 84273.0 116413.0 110049.0 79454.0 108662.0 True False 111377.81155920083 120306.86860891727 103650.66408596672 96197.75868293422 86669.40819807691 95880.84079587353 121826.43516798336 110369.2243704074 95347.02013024785 105524.64572221816 1.0554672872571442 1.1400831321017808 0.9822412894786258 0.9116141354898653 0.8213191108570451 0.908610876062727 1.1544832426036078 1.045909451910808 0.9035521463037007 1.0 16.687220460182004 -5.3479764311273135 5.911388739166044 0.9642590221570138 1.0970377742579582 0.26418445638822363 0.08822912325706128 0.31348234889881116 16.909030390820327 0.025919744257319504 0.055192342886132444 4.487697437078119e-06 5.3479764311273135 0.13277875210094447 IVQISGNS(ph)MPR ddPTM_A459_Selumetinib_30min_R2 1 IVQISGNSMPR 11 0 Q9NWH9;Q9NWH9-3;H7C3F4;H0YKH2 Q9NWH9 SLTM SAFB-like transcription modulator 1 IVQIS(0.429)GNS(0.571)MPR 78.985 0.046542 2540000.0 12655.0 7931.7 10359.0 9967.2 9488.0 8297.0 7983.2 7476.5 6076.2 8706.9 True False 11951.685761978832 8540.03588556476 9692.51321802641 8609.650165620966 8296.032616203798 9439.83643733298 8354.434618410698 7498.255377198796 7291.609783213078 8455.509173756991 1.4134791313422943 1.0099966436166978 1.1462956303221403 1.0182296522535126 0.9811393312601264 1.116412535702877 0.9880463076475638 0.8867893373554389 0.8623501711574912 1.0 13.045675918107065 -1.5228787452803376 0.7071550419301414 0.9743341206837695 52.24935070848248 0.6733517246237437 0.08491494311096338 190.92876408365368 0.9846698125676999 0.03454445875558207 15497.438588467974 0.029999999999999995 1.5228787452803376 51.27501658779871 IVS(ph)DGEDEDDSFK ddPTM_A459_Selumetinib_30min_R2 2 IVSDGEDEDDSFK 13 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 IVS(1)DGEDEDDSFK;IVS(1)DGEDEDDSFK 138.31 0.00099486 12660600.0 52710.0 32149.0 44990.0 42296.0 47473.0 41257.0 70972.0 65054.0 48778.0 34798.0 True False 49780.589214848245 34614.72492467207 42095.392381408295 36535.21183533032 41509.01732599524 46939.777256242836 74272.33862834999 65243.29636973053 58534.96297119374 33793.291323937985 1.4730908788273434 1.024307593861158 1.2456730532071434 1.0811380130188757 1.2283212347709886 1.389026502517449 2.197842699498704 1.9306582405459412 1.732147437492412 1.0 15.044449249301826 -7.046028914710672 6.8618616171298505 1.7952364011215511 1.2050466706969603 0.36580403841438536 0.30646171540226347 0.20853795104514564 25.27824805911674 0.11087634707885662 0.08696593213107617 8.99437696250319e-08 7.046028914710672 -0.5901897304245909 IVS(ph)PGLTIHER ddPTM_A459_Selumetinib_30min_R2 2 IVSPGLTIHER 11 0 A0A0U1RR07;Q9HCH5-15;Q9HCH5-14;Q9HCH5-6;Q9HCH5;Q9HCH5-13 A0A0U1RR07 SYTL2 Synaptotagmin-like protein 2 1 IVS(1)PGLTIHER;IVS(1)PGLTIHER 149.57 0.000416 2144500.0 28049.9 24476.0 27903.0 26781.0 26179.0 19966.0 19136.8 19538.5 22329.0 24014.4 True False 26490.99885064638 26353.23049725569 26107.75135848935 23133.381600198143 22890.159976770574 22716.13526669764 20026.699118849818 19595.353800227207 26795.423924387742 23321.04187509558 1.1359269020881946 1.1300194321677441 1.1194933527549507 0.9919531779110676 0.9815239001485117 0.9740617674099752 0.8587394691073483 0.8402434979182034 1.148980567330589 1.0 14.509344622395629 -5.828753792066867 2.0649198855682585 0.9531501873868803 1.137250556732041 0.4465371226435121 0.07982722002692906 0.27987655536740474 2.436444606713967 0.024846715986714146 0.04544197344193152 1.483358784746033e-06 5.828753792066867 0.18410036934516072 IWAHEALR ddPTM_A459_Selumetinib_30min_R1 1 IWAHEALR 8 0 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 122.18 0.006603 0.0 3363.7 3733.3 5515.6 5887.1 3423.8 3410.3 2772.0 2920.5 1632.9 2556.5 False True 3442.0676653791606 3296.2035004359177 4766.611815022117 4859.028499553625 3114.117894520985 3375.9954783046537 2562.9058082499973 2843.0388528790345 2770.912037702656 2884.6516774187703 1.1932351113043826 1.1426695036488461 1.6524046394701468 1.684442020362596 1.0795472877708217 1.1703303746279499 0.8884628353269064 0.9855744023219567 0.9605707543110057 1.0 11.494181408177813 -6.428544996867197 6.504584627047905 1.0067007509229207 1.4149201977158665 0.5724982008587405 0.1720648532391599 0.203687773483385 11.82762279181479 0.05968365658238386 0.06752432566743803 3.727820593225152e-07 6.428544996867197 0.40821944679294586 IWDMTPVVGCSLATGFS(ph)PH ddPTM_A459_Selumetinib_30min_R1 1 IWDMTPVVGCSLATGFSPH 19 0 Q8IWB7 Q8IWB7 WDFY1 WD repeat and FYVE domain-containing protein 1 1 IWDMTPVVGCS(0.009)LAT(0.022)GFS(0.969)PH 116.78 0.0004643 3843000.0 1135.5 1116.9 1342.5 1559.0 1125.2 1018.0 1157.9 1346.1 764.16 924.97 True False 1161.9549407016198 986.1328287672773 1160.1958738246412 1286.7499160544417 1023.4258586701952 1007.7598442700457 1070.5586707693615 1310.3970552509738 1296.7237079618233 1043.698909470776 1.1133047377531584 0.9448441689637401 1.1116193217188823 1.2328746388236704 0.9805757669988746 0.9655656771559206 1.0257351627513007 1.2555316896090571 1.24243083536357 1.0 10.027489862026334 -7.750126174362755 24.974598595918163 1.1867359539327609 1.052270679767966 0.19036054954003667 0.10366910325751102 292.75178055870134 646271.407198004 0.050350809362907645 0.028731642450145173 1.7777628465305277e-08 7.750126174362755 -0.13446527416479492 IWDPTPSHTPAGAAT(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 IWDPTPSHTPAGAATPGR 18 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 IWDPTPS(0.002)HT(0.027)PAGAAT(0.971)PGR 74.36399999999998 0.022142 7509700.0 2936.5 4396.3 2931.3 2736.5 2858.6 2642.7 3666.4 3334.7 1655.3 3050.1 True False 3004.9147365656586 3881.5791522155773 2533.24556047834 2258.6216454669516 2600.04013472682 2616.1168373796163 3389.8404961644255 3246.2529233678174 2808.923201671387 3441.610045489924 0.8731130769749655 1.1278381632173038 0.7360640883176306 0.65626890194221 0.7554720320897645 0.7601433058367321 0.9849577527258383 0.9432367062101898 0.8161654471436575 1.0 11.748867925529813 -10.009969720641108 11.331741533556354 0.9999999999999992 0.8506988051055642 0.10416604878681235 0.131644387138644 0.0 0.0 0.13887290138324337 0.03368162593759397 9.773053570922727e-11 10.009969720641108 -0.14930119489443505 IWDPTPSHTPAGAAT(ph)PGR ddPTM_A459_Selumetinib_30min_R2 5 IWDPTPSHTPAGAATPGR 18 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 IWDPTPSHT(0.019)PAGAAT(0.981)PGR;IWDPTPSHT(0.013)PAGAAT(0.987)PGR;IWDPT(0.003)PS(0.083)HT(0.448)PAGAAT(0.466)PGR;IWDPTPSHT(0.019)PAGAAT(0.981)PGR;IWDPTPSHT(0.002)PAGAAT(0.998)PGR 119.38 0.0013239 59360200.0 191190.0 135886.0 182032.0 189870.0 202267.0 176613.0 213741.0 208316.0 203958.0 167625.0 True False 180564.42519421046 146308.01925764373 170320.25930145572 164009.37845598097 176856.41117007713 200939.83761681197 223680.3800197566 208922.16507142983 244755.2990626661 162785.230707946 1.109218719713966 0.8987794446790806 1.0462881587029744 1.0075200172811207 1.0864401543121336 1.2343861709255393 1.3740827656598833 1.283422114910771 1.5035473304195706 1.0 17.312610286135694 -6.752566816021834 2.253367924015346 1.3145740129094237 1.0101220039121825 0.49227700215874304 0.1279238648436174 0.22380472694674042 2.3341118347670013 0.04648460897216506 0.043125401428203196 1.7678002214973417e-07 6.752566816021834 -0.3044520089972411 IWHHTFYNELR ddPTM_A459_Selumetinib_30min_R1 2 IWHHTFYNELR 11 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;A5A3E0;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;A6NL76;P0CG38;P0CG39 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;POTEKP;ACTG1;ACTA1;ACTC1;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 ; 88.134 0.017527 488440000.0 15058.3 14132.9 13771.7 14592.3 22356.8 13697.8 14211.2 11144.900000000001 3089.4 5997.6 False True 15409.12909164879 12478.21349779304 11901.578782533192 12044.02873639591 20334.631387413636 13560.012568607302 13139.237742497247 10849.30104826282 5242.486159151558 6767.450381571212 2.2769474798973293 1.8438574048171963 1.758650320502236 1.7796995998956442 3.004769926764133 2.0037106744858093 1.9415344038986044 1.6031593046928134 0.7746619278403043 1.0 12.724396689411366 -8.018531492700257 2.201809857663951 0.8762826512560044 2.0949486817395098 0.6524641108485966 0.3474965610336131 0.2114350806391519 1.8827944197068929 0.30435539860367494 0.10181222620850908 9.582272283015635e-09 8.018531492700257 1.2186660304835053 IWLS(ph)TETLANED ddPTM_A459_Selumetinib_30min_R1 2 IWLSTETLANED 12 0 Q9NXD2 Q9NXD2 MTMR10 Myotubularin-related protein 10 1 IWLS(0.897)T(0.103)ETLANED;IWLS(0.836)T(0.164)ETLANED 114.86 0.0053973 16168100.0 3205.91 3294.8399999999997 4314.42 4154.51 3853.32 3277.25 3847.45 3382.94 1624.94 2550.31 True False 3280.601465385054 2909.078601070441 3728.545461412673 3429.0028183113136 3504.787886358901 3244.283840504918 3557.2337489002357 3293.2134418622136 2757.404499078054 2877.667130623065 1.140021175650968 1.0109156024729569 1.2956833755144495 1.1915911961536965 1.21792678835653 1.1274006663176759 1.236151920090227 1.1444038842495226 0.9582082895324407 1.0 11.49068400503316 -8.202402689445323 4.90719812070864 0.9785849205872563 1.1738567741198405 0.5312310579119723 0.07216734851489078 0.15497885435265207 7.660585194899461 0.054685270303345385 0.018867875601573707 6.2747627622809855e-09 8.202402689445323 0.19527185353258414 IWLS(ph)TETLANED ddPTM_A459_Selumetinib_30min_R2 2 IWLSTETLANED 12 0 Q9NXD2 Q9NXD2 MTMR10 Myotubularin-related protein 10 1 IWLS(0.847)T(0.152)ETLANED;IWLS(0.851)T(0.119)ET(0.03)LANED 116.84 0.0046945 960580.0 8009.700000000001 4587.6 6418.0 8030.9 8800.6 7125.9 8226.4 6822.1 3473.1 7418.7 True False 7564.552939369571 4939.454168541034 6005.072867390046 6937.077565924776 7694.989949637767 8107.428042520317 8608.943900302349 6841.951181540545 4167.8170465220555 7204.502854902546 1.0499757015464317 0.6856065252552183 0.8335166198599939 0.9628808129632718 1.0680806302132912 1.12532789642846 1.1949393419206025 0.9496770727052609 0.57850168574587 1.0 12.81468316565028 -4.457477444380219 22.628806233564955 0.9431057693530752 4.2772216494708815 0.03364491392625091 0.18087750987490334 2226.76551961435 800117.7483390145 0.04692395405386728 14412.951143423123 3.4875669677423115e-05 4.457477444380219 3.3341158801178064 IWLST(ph)ETLANED ddPTM_A459_Selumetinib_30min_R1 1 IWLSTETLANED 12 0 Q9NXD2 Q9NXD2 MTMR10 Myotubularin-related protein 10 1 IWLS(0.052)T(0.947)ETLANED 224.66 1.9925e-08 13702000.0 3933.5 4092.7 4599.8 4616.7 3877.3 3506.2 3644.0 3456.8 1927.4 2919.4 True False 4025.142896741364 3613.5247813553883 3975.1724248928017 3810.4800111921363 3526.5988995929138 3470.9308113748866 3369.13014619877 3365.114434731123 3270.657028273684 3294.1334273641114 1.2219125258572752 1.0969576251338569 1.2067429910007141 1.1567473192004833 1.0705695374382014 1.0536703773265932 1.022766752011824 1.0215477025846549 0.9928732701306477 1.0 11.685683276610996 -6.521171473805697 1.329126815792956 1.0106860265341577 1.1732367500277134 0.8282516787854617 0.03306440904528924 0.16988126163286235 0.621340741284227 0.013795705466684842 0.015448027655230071 3.0118166247142396e-07 6.521171473805697 0.1625507234935557 IWS(ph)PTIGR ddPTM_A459_Selumetinib_30min_R2 2 IWSPTIGR 8 0 Q92545 Q92545 TMEM131 Transmembrane protein 131 1 IWS(0.998)PT(0.002)IGR;IWS(0.991)PT(0.009)IGR 96.034 0.021405 3844200.0 9744.099999999999 6789.2 9742.0 9323.0 8197.0 5749.400000000001 9685.5 8179.1 6091.4 9030.4 True False 9202.561930722874 7309.909809281267 9115.21032628761 8053.191316927953 7167.219577890234 6541.327662143217 10135.89494145416 8202.899826877105 7309.850207936558 8769.66888820304 1.049362529878655 0.8335445616555215 1.0394018796478615 0.9183004990942255 0.8172736815105505 0.7459036077111888 1.155789924416527 0.9353716692669717 0.8335377653504992 1.0 13.098306657279034 -10.232280943287638 16.002991419127007 0.9999999841284452 0.9244424758580814 0.033939453343186265 0.11932597061736581 0.0 0.0 0.11537796461565637 0.027983266763478135 5.857591167973033e-11 10.232280943287638 -0.07555750827036378 IWSTVPT(ph)DEEDEMEESTNRPR ddPTM_A459_Selumetinib_30min_R1 1 IWSTVPTDEEDEMEESTNRPR 21 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 IWSTVPT(1)DEEDEMEESTNRPR 148.52 3.3895e-06 8657900.0 1119.1 1244.7 1153.2 1336.3 1452.1 1152.2 1182.3 1086.4 899.3 996.64 True False 1145.172852610464 1098.9699453546696 996.6017740741727 1102.9402904576973 1320.7578113890781 1140.6099141138968 1093.1181591248092 1057.5851428754602 1526.0464177267431 1124.568452095695 1.018322050984421 0.9772370399566863 0.8862081914328565 0.9807675899162097 1.174457463151997 1.0142645492040148 0.972033456111741 0.9404364322194814 1.3570062497154993 1.0 10.135155764802565 -6.023651660759297 23.852305843828805 1.0662070134735084 0.957459543282434 0.17488580627407324 0.11714213215410935 790.0380675534933 796740.4955819007 0.03427867815358945 0.04457283884005704 9.469964244256202e-07 6.023651660759297 -0.10874747019107445 IWSTVPT(ph)DEEDEMEESTNRPR ddPTM_A459_Selumetinib_30min_R2 2 IWSTVPTDEEDEMEESTNRPR 21 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 IWS(0.002)T(0.002)VPT(0.995)DEEDEMEESTNRPR;IWS(0.004)T(0.014)VPT(0.982)DEEDEMEESTNRPR 83.064 0.0019887 7017500.0 27102.1 22915.2 27202.4 30642.4 33750.1 24553.3 23725.8 28137.5 20249.8 27105.0 True False 25595.873780302383 24672.72215601872 25452.22719973374 26468.852258911607 29510.110708277818 27935.29420233433 24829.096711780814 28219.37546658613 24300.32582668579 26322.408222752445 0.9723986332746689 0.9373276923306821 0.9669414357662556 1.0055634740909678 1.1211022357281886 1.0612742559849728 0.9432684312797471 1.0720666296100518 0.9231801900891873 1.0 14.684003866042252 -5.7891996308419245 3.95491773719075 1.0249853913208995 0.9553045857959954 0.1901013907567599 0.05587348549560677 0.32520959629975416 10.998360316185702 0.016088598370842394 0.026313619266074298 1.6248017163372457e-06 5.7891996308419245 -0.06968080552490408 IWYEHR ddPTM_A459_Selumetinib_30min_R2 3 IWYEHR 6 0 O75874;H0YL11;P48735-2;P48735 O75874 IDH1;IDH2 Isocitrate dehydrogenase [NADP] cytoplasmic;Isocitrate dehydrogenase [NADP], mitochondrial 0 ;; 164.83 0.00032268 26447700.0 50891.5 44661.7 50791.3 53158.5 49750.4 40155.0 45766.3 49664.2 45629.8 42881.5 False True 48063.15416481595 48087.10878000023 47523.44305538613 45918.22059647264 43500.30997778094 45685.98675920284 47894.523634203 49808.71459964908 54757.03500313619 41643.39967548271 1.1541601919958717 1.1547354239743113 1.1411998882349959 1.102653024352061 1.0445907470756157 1.0970762981702518 1.150110798048042 1.1960770491313573 1.3149030922029656 1.0 15.345800231442059 -7.552890764528189 3.903173002045627 1.1905739017118415 1.1151343924028967 0.07452945331054506 0.0781539192624289 0.42059104797214825 14.088333031796147 0.0377719408408076 0.021527827644367545 2.799685419070316e-08 7.552890764528189 -0.07543950930894483 IY(ph)NS(ph)TYLGY(ph)ETLFLELS(ph)IQQ ddPTM_A459_Selumetinib_30min_R2 1 IYNSTYLGYETLFLELSIQQ 20 0 K7EPY8 K7EPY8 4 IY(0.589)NS(0.701)T(0.455)Y(0.307)LGY(0.941)ET(0.158)LFLELS(0.85)IQQ 51.773 0.016206 28969000.0 0.0 0.0 0.0 0.0 0.0 0.0 521.97 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 546.242639263933 0.0 0.0 0.0 0.0 IYASS(ph)SPPDTGQR ddPTM_A459_Selumetinib_30min_R1 3 IYASSSPPDTGQR 13 0 A0A494C0H7;A0A494C094;F8WDA1;A0A494C188;A0A494C155;A0A494C1K7;Q9UGJ0-3;Q9UGJ0;E9PGP6 A0A494C0H7 PRKAG2 5-AMP-activated protein kinase subunit gamma-2 1 IYAS(0.011)S(0.533)S(0.449)PPDT(0.007)GQR;IYAS(0.002)S(0.499)S(0.499)PPDTGQR;IYAS(0.002)S(0.499)S(0.499)PPDTGQR 161.87 0.00036352 37835200.0 5760.9 6509.9 7038.3 6869.5 6863.1 5495.0 5711.4 5313.2 2927.32 3822.4000000000005 True False 5895.117761239949 5747.717881629593 6082.537518614511 5669.870781485554 6242.3338167787215 5439.725289060806 5280.584499725479 5172.276676294088 4967.448237006391 4313.042273328966 1.3668119595521326 1.3326365746916946 1.4102661493089848 1.3145873428013812 1.4473157045967595 1.2612269818682358 1.224329409516714 1.199217709568595 1.1517272315470095 1.0 12.074490141059838 -8.014672718843368 0.6093336272528161 1.0061792399785814 1.3787409542724876 0.8692185689431733 0.04580875619687489 0.24478805577912008 0.20207460002625122 0.04484049854979286 0.022656086183422124 9.667791622721248e-09 8.014672718843368 0.37256171429390617 IYASSS(ph)PPDTGQR ddPTM_A459_Selumetinib_30min_R1 1 IYASSSPPDTGQR 13 0 A0A494C0H7;A0A494C094;F8WDA1;A0A494C188;A0A494C155;A0A494C1K7;Q9UGJ0-3;Q9UGJ0;E9PGP6 A0A494C0H7 PRKAG2 5-AMP-activated protein kinase subunit gamma-2 1 IYAS(0.001)S(0.131)S(0.868)PPDTGQR 178.22 0.00010614 8065400.0 3544.1 3948.0 3774.8 4434.4 5104.2 3552.7 3787.9 3950.8 1209.3 1920.0 True False 3626.6706343818646 3485.766324624594 3262.202893492186 3660.0152839973134 4642.526011219699 3516.9630635935096 3502.175653344215 3846.011949992978 2052.093776222562 2166.4507023837414 1.6740148439064162 1.608975602717021 1.5057821947680556 1.689406216338182 2.14291790997669 1.623375532950647 1.6165498940228726 1.7752593888987267 0.947214618806995 1.0 11.081117693099387 -8.263617148796223 24.999997163302787 0.9736071938056924 1.7031950793428314 0.764912371301636 0.16208391166802297 96.46969337411295 1107397.561249668 0.14180392783443546 0.04354754667211656 5.449828694167303e-09 8.263617148796223 0.729587885537139 IYASSS(ph)PPDTGQR ddPTM_A459_Selumetinib_30min_R2 2 IYASSSPPDTGQR 13 0 A0A494C0H7;A0A494C094;F8WDA1;A0A494C188;A0A494C155;A0A494C1K7;Q9UGJ0-3;Q9UGJ0;E9PGP6 A0A494C0H7 PRKAG2 5-AMP-activated protein kinase subunit gamma-2 1 IYAS(0.194)S(0.144)S(0.659)PPDT(0.002)GQR;IYAS(0.024)S(0.14)S(0.836)PPDTGQR 109.15 0.0060346 21664400.0 44129.0 44506.0 73745.0 104998.0 87093.0 61161.0 46671.0 41783.0 40928.0 93059.0 True False 41676.48684238355 47919.46709065461 69000.32698748524 90697.09126834707 76151.59871870125 69585.37258572034 48841.29397683205 41904.58161245197 49114.743623867675 90372.1448736806 0.4611651842571365 0.5302459862785702 0.763513216200985 1.0035956476978682 0.8426445872801138 0.7699869543097004 0.5404463293982997 0.4636891342019701 0.5434721472254392 1.0 16.46359054328238 -11.889041761445972 2.3531987114061477 3.42342520127912 0.666776454099715 0.26025147691998707 0.17254317215164242 12377489.860449748 1005348.5030018945 161468581.38191512 0.05198641715795123 1.2910951168635514e-12 11.889041761445972 -2.756648747179405 IYGADDIELLPEAQHK ddPTM_A459_Selumetinib_30min_R2 2 IYGADDIELLPEAQHK 16 0 V9GZ78;V9GYY3;A0A384N5Y3;F5H2F4;P11586 V9GZ78 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 ; 141.34 0.00055807 2758300.0 32908.0 34734.0 32160.0 35599.0 35562.0 29566.0 28596.0 31404.0 25975.0 29086.0 False True 31079.10510116154 37397.986112587016 30090.860613160497 30750.35478829969 31094.38363168629 33638.44812657429 29925.770661899012 31495.38044078794 31170.725802139445 28246.211605496286 1.1002928652957487 1.3240000689264089 1.0653060677101658 1.0886541252957311 1.100833770771433 1.190901229389245 1.0594613918447 1.1150302518678086 1.1035365109306938 1.0 14.785769765149325 -5.938271600607864 0.017699237129421036 7.91493920895319e-11 2.2833649254674175 0.2702029722198467 0.07119972208343656 1671.6840514767 7.188218126160785 426.27885226515133 501.8028862607472 1.1527321326864256e-06 5.938271600607864 2.283364925388268 IYHLPDAES(ph)DEDEDFK ddPTM_A459_Selumetinib_30min_R1 3 IYHLPDAESDEDEDFK 16 0 B5MCX3;Q15019;Q15019-3;Q15019-2;H7C2Y0 B5MCX3 SEPT2 Septin-2 1 IYHLPDAES(1)DEDEDFK;IYHLPDAES(1)DEDEDFK;IYHLPDAES(1)DEDEDFK 221.13 4.747100000000001e-11 32947500.0 16458.1 19488.7 11646.7 11973.4 10653.3 12637.599999999999 16126.0 15604.3 9057.4 17949.9 True False 16841.541708112116 17206.95394394917 10065.142110743729 9882.470458554355 9689.710895992883 12510.47721802272 14909.602836882917 15190.423274090164 15369.746273677532 20253.944511832255 0.8315190998115636 0.8495606341716279 0.4969472541441852 0.48792818864399795 0.478411051750053 0.617681025575742 0.7361332913780227 0.7499982665211704 0.7588519986661661 1.0 14.305915283767979 -8.539402107272117 0.8688204040111084 0.9930658103446849 0.6261495542125746 0.4238104049487549 0.12679281960701505 0.7179309822647411 1.2015283123818252 0.13828284734583363 0.048822840600932164 2.888004680380672e-09 8.539402107272117 -0.3669162561321103 IYHLPDAES(ph)DEDEDFK ddPTM_A459_Selumetinib_30min_R2 5 IYHLPDAESDEDEDFK 16 0 B5MCX3;Q15019;Q15019-3;Q15019-2;H7C2Y0 B5MCX3 SEPT2 Septin-2 1 IYHLPDAES(1)DEDEDFK;IYHLPDAES(1)DEDEDFK;IYHLPDAES(1)DEDEDFK;IYHLPDAES(1)DEDEDFK;IYHLPDAES(1)DEDEDFK 208.59 1.0929e-20 26364700.0 215673.0 145328.80000000002 160399.9 162947.5 170931.0 155737.0 216009.0 212663.0 165525.1 135246.6 True False 203686.75806742476 156475.0516542562 150079.9450642066 140753.7693998837 149457.11963747157 177188.35811027186 226053.84651371327 213281.8141217451 198634.7451577172 131341.679245132 1.5508158509780448 1.191358695530427 1.1426680846991617 1.0716611071888709 1.1379260604589156 1.3490642051223745 1.7211128090711667 1.6238700110090918 1.5123511919395483 1.0 17.002965280222213 -7.0088812447040265 7.068605259098999 1.5195182859871246 1.2080429758017952 0.20635519618916753 0.21612485057374575 0.1742295744554677 50.225468173531006 0.07799935939045877 0.06441411490469331 9.7975785786133e-08 7.0088812447040265 -0.31147531018532937 IYHLPDAES(ph)DEDEDFKEQTR ddPTM_A459_Selumetinib_30min_R1 9 IYHLPDAESDEDEDFKEQTR 20 1 B5MCX3;Q15019;Q15019-3;Q15019-2;H7C2Y0 B5MCX3 SEPT2 Septin-2 1 IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(0.998)DEDEDFKEQT(0.001)R;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR 154.42 2.0612e-06 5507820000.0 67907.09999999999 81253.79999999999 90009.99999999999 94586.5 66893.9 73450.0 70524.3 71836.00000000001 48415.5 67855.5 True False 69489.2033057851 71740.56732213324 77787.13638953882 78068.74338350444 60843.358556077226 72711.15968726415 65204.59527156034 69930.67592378637 82157.56737178814 76565.41439354174 0.9075795364812455 0.9369839880104472 1.0159565778579542 1.0196345700192475 0.7946585157019582 0.9496606302361672 0.8516194392472369 0.9133454899668773 1.0730375852144294 1.0 16.224405234484585 -8.25323462751187 24.346154908016462 1.0365187953315091 0.9245609946644884 0.31912120822893486 0.06591888213042985 476.1917558860968 1413029.801273982 0.04816938876600339 0.017484987812389708 5.581685628051745e-09 8.25323462751187 -0.11195780066702077 IYHLPDAES(ph)DEDEDFKEQTR ddPTM_A459_Selumetinib_30min_R2 11 IYHLPDAESDEDEDFKEQTR 20 1 B5MCX3;Q15019;Q15019-3;Q15019-2;H7C2Y0 B5MCX3 SEPT2 Septin-2 1 IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(0.998)DEDEDFKEQT(0.002)R;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(0.999)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(0.987)DEDEDFKEQT(0.013)R;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR;IYHLPDAES(1)DEDEDFKEQTR 118.46 0.00014219 5461456900.0 1652649.0 1573787.0 1525885.0 1493361.0 1449366.0 1127214.0 1291309.0 1240442.0 1016538.4 1418345.0 True False 1560801.3846581224 1694491.402377212 1427711.220357969 1289962.6556085874 1267283.6855835617 1282477.496670106 1351357.4271802404 1244051.4808537723 1219874.4844560362 1377393.6945471212 1.1331556045574207 1.23021573939639 1.0365309686039994 0.9365242927387725 0.9200591599921887 0.931090001171943 0.9810974397008247 0.9031923739587098 0.8856396608212467 1.0 20.39350954709132 -5.497835599780369 3.0960821432759262 0.9340225579036692 1.1808138238899162 0.8579749250456894 0.03950033663091433 0.08009332540317089 1.5460006796618304 0.010704507317095706 0.02342828871909444 3.178076889663919e-06 5.497835599780369 0.246791265986247 IYHLPDAESDEDEDFKEQTR ddPTM_A459_Selumetinib_30min_R1 1 IYHLPDAESDEDEDFKEQTR 20 1 B5MCX3;Q15019;Q15019-3;Q15019-2;H7C2Y0 B5MCX3 SEPT2 Septin-2 0 115.58 0.00021532 6035300.0 4183.7 4749.0 5755.1 5587.4 4386.4 4640.7 4388.1 4685.0 2828.0 4554.5 False True 4281.17206993691 4192.9848722497945 4973.589030501451 4611.665478487867 3989.6508944818193 4594.018771418468 4057.102084120422 4560.738580975272 4798.909451052184 5139.114439586854 0.833056379705972 0.8158963808922065 0.9677910638046211 0.8973657879583258 0.7763304245084212 0.8939319848630948 0.7894554853397238 0.887456123927437 0.9338008537202335 1.0 12.327304063597557 -8.426065515179607 2.1441220041355686 0.9975129051624582 0.8562278699025777 0.42672680523412376 0.053970010509284835 0.2940272216519107 2.848103636743238 0.05259889235308827 0.01471248314207191 3.749164402311555e-09 8.426065515179607 -0.14128503525988045 IYISNTFS(ph)PSKAEGDSAGTAGTPGGTPAGDK ddPTM_A459_Selumetinib_30min_R1 1 IYISNTFSPSKAEGDSAGTAGTPGGTPAGDK 31 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 IY(0.008)IS(0.009)NT(0.106)FS(0.626)PS(0.062)KAEGDS(0.106)AGT(0.058)AGT(0.025)PGGTPAGDK 61.112 0.00081428 16060000.0 779.31 1242.2 1113.5 863.51 734.26 772.03 933.56 848.63 475.04 679.9 True False 797.4664067267095 1096.7626465168871 962.2928160176821 712.7141885902315 667.8463126441321 764.2640791471547 863.1408175865321 826.1215756612684 806.1081844511418 767.1717877868263 1.0394887030808035 1.4296180646591297 1.2543381174036004 0.929015117521857 0.8705303339826495 0.9962098337217797 1.1250945763745586 1.076840401084747 1.0507531654372237 1.0 9.58340585699154 -5.7490168732003 24.819120759688666 1.0089168989786765 1.2599954061797405 0.48114050311894907 0.11093435840037782 173.34582155573398 346326.87098883896 0.031162637057510868 0.05347954100204794 1.7823095198500005e-06 5.7490168732003 0.25107850720106395 IYISNTFS(ph)PSKAEGDSAGTAGTPGGTPAGDK ddPTM_A459_Selumetinib_30min_R2 1 IYISNTFSPSKAEGDSAGTAGTPGGTPAGDK 31 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 IY(0.008)IS(0.029)NT(0.211)FS(0.539)PS(0.211)KAEGDS(0.001)AGTAGTPGGTPAGDK 73.166 4.0671e-05 9831600.0 70595.0 51650.0 51046.0 58677.0 59043.0 42985.0 58259.0 61037.0 41565.0 55049.0 True False 66671.61251417595 55611.38891907404 47761.75593468254 50685.091376529126 51625.49048888289 48905.79357102066 60968.158938018416 61214.6075647807 49879.16142313478 53459.592335521054 1.2471403091840678 1.0402508977256684 0.8934178853239663 0.9481009705128556 0.9656918100847638 0.9148179294761543 1.1404531212167197 1.1450631194601695 0.933025472960682 1.0 15.70616121567581 -10.178786377163691 15.286251179563337 1.0000046589663842 1.0215200082833953 0.003567635926166046 0.11171269633416886 0.0 0.0 0.1129762197740398 0.02740075807713887 6.625423180316814e-11 10.178786377163691 0.021515349317011045 IYISNTFSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 IYISNTFSPSK 11 0 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 IYISNT(0.012)FS(0.175)PS(0.812)K 107.39 0.010575 3960900.0 25121.0 21150.0 25430.0 28581.0 21800.0 25725.0 24606.0 24225.0 19942.0 17620.0 True False 23724.875387330725 22772.13699203131 23793.86148609052 24688.218495024972 19061.289105527267 29268.385241700715 25750.22775586403 24295.490739335357 23930.957226035214 17111.264817742034 1.3865062366828245 1.3308272202309515 1.390537855589702 1.4428050034867486 1.1139614346780096 1.7104746816467602 1.5048699222493813 1.4198535875702343 1.3985498723169836 1.0 14.062658783376909 -8.863584294764625 4.2213813312682475 1.0000001419792466 1.4129442997525044 0.4379633476719631 0.13973207288791797 15.986303668929056 197.50436384876397 0.1361242977363865 0.035569224886873856 1.3690386378581556e-09 8.863584294764625 0.41294415777325777 IYISNTFSPS(ph)KAEGDSAGTAGTPGGTPAGDK ddPTM_A459_Selumetinib_30min_R2 1 IYISNTFSPSKAEGDSAGTAGTPGGTPAGDK 31 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 IY(0.002)IS(0.016)NT(0.124)FS(0.37)PS(0.484)KAEGDS(0.002)AGT(0.001)AGT(0.001)PGGTPAGDK 70.109 0.00010785 9793200.0 64315.0 52832.0 54621.0 61608.0 56744.0 50586.0 62201.0 60134.0 44944.0 55806.0 True False 60740.62977334405 56884.04451834504 51106.74432684824 53216.8841202721 49615.311422203624 57553.762326012584 65093.46974894326 60308.97998428039 53934.05584028311 54194.735778598886 1.120784683248333 1.0496230621131315 0.9430204537878737 0.9819567040178664 0.9155005686326523 1.0619806794729343 1.20110318490838 1.1128198914127 0.9951899398609354 1.0 15.725865101332422 -6.987795401536663 24.965415682881428 1.0930887772979605 0.9992368790185662 0.17261571185333768 0.0762164212599954 330.2112343151876 675469.3390834609 0.027967331616845666 0.02464762992418995 1.0285007162237712e-07 6.987795401536663 -0.09385189827939433 IYNISGNGS(ph)PLADSK ddPTM_A459_Selumetinib_30min_R1 1 IYNISGNGSPLADSK 15 0 Q53HL2 Q53HL2 CDCA8 Borealin 1 IYNISGNGS(0.98)PLADS(0.02)K 218.64 2.7532e-09 7047100.0 2097.1 2382.2 2387.1 2554.5 1797.3 2107.2 2182.8 1822.4 1111.0 1656.0 True False 2145.9583497537346 2103.2909165452647 2062.9449314017143 2108.40452890383 1634.734532339087 2086.0034811845194 2018.1496386176375 1774.0640320105294 1885.2858557705003 1868.5637308059765 1.1484533892928062 1.1256190419783232 1.1040270649542654 1.1283556959517789 0.8748615342298062 1.1163673182743163 1.0800539501786965 0.9494265583573721 1.0089491863129072 1.0 10.867714054990193 IYNISGNGS(ph)PLADSK ddPTM_A459_Selumetinib_30min_R2 3 IYNISGNGSPLADSK 15 0 Q53HL2 Q53HL2 CDCA8 Borealin 1 IYNIS(0.005)GNGS(0.955)PLADS(0.04)K;IYNISGNGS(0.991)PLADS(0.009)K;IYNISGNGS(0.903)PLADS(0.097)K 166.3 8.0515e-05 115048000.0 215831.0 208344.0 232243.0 248898.0 208820.0 194463.0 222613.0 213956.0 187276.0 215038.0 True False 203835.97705994884 224323.3148684529 217300.7382270589 214997.66302700073 182586.16472551378 221248.51309064514 232964.94559929107 214578.57653767767 224736.43292864124 208829.2942041775 0.9760890005242915 1.0741946704523482 1.040566358542584 1.0295378521788818 0.8743321449288375 1.0594706740440594 1.1155759850986977 1.027531014532276 1.0761729276780054 1.0 17.67196457925023 -6.942226606229955 24.999997642735636 1.0614627370814114 1.0031131355325376 0.19377057013154664 0.0570456885437084 137.37097117808386 59443.15941173254 0.02065172566709907 0.018213107497129327 1.1422821591368452e-07 6.942226606229955 -0.05834960154887381 IYNISGNGSPLADS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 IYNISGNGSPLADSK 15 0 Q53HL2 Q53HL2 CDCA8 Borealin 1 IYNIS(0.001)GNGS(0.088)PLADS(0.91)K 89.46600000000002 0.016567 112510000.0 1487.3 1926.9 2170.8 2116.4 1521.3 1697.2 1875.1 1648.5 1100.0 1599.6 True False 1521.9511962179813 1701.297652208494 1876.0172833508618 1746.8104697483122 1383.6986836073302 1680.127708934304 1733.6596973483292 1604.7764249173392 1866.6196591787127 1804.9242414234557 0.8432216495788725 0.9425867375279771 1.0393883800193955 0.9678026532408297 0.766624244858097 0.9308577448155216 0.9605166009522241 0.8891101288837089 1.0341817215035025 1.0 10.817722568413636 -8.266857433286884 24.758852186398993 1.017090872786705 0.9209366924402972 0.24048446128475487 0.07057622052612346 668.3888708606668 3054277.2259443793 0.06455202612557802 0.018629111534908035 5.4093186658210564e-09 8.266857433286884 -0.09615418034640777 IYNISGNGSPLADS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 IYNISGNGSPLADSK 15 0 Q53HL2 Q53HL2 CDCA8 Borealin 1 IYNISGNGS(0.034)PLADS(0.966)K 210.57 1.1557e-06 28469000.0 68524.0 64802.0 73961.0 71461.0 74670.0 56122.0 61566.0 64845.0 54502.0 65576.0 True False 64715.71040330596 69772.10502872875 69202.42978264805 61727.88852289912 65289.28704173038 63852.29607520809 64428.9409907146 65033.68821433236 65403.92291311662 63682.65049309026 1.0162219992763617 1.0956218764214158 1.0866763435067248 0.9693046386251898 1.0252287952244457 1.00266392150459 1.0117188981904155 1.0212151615986633 1.0270289067226108 1.0 15.95861276212795 -5.747382396559647 24.999621946481295 1.0096794857384501 1.0691182630605582 0.528691697976917 0.025023595202139898 176.6598967464291 314178.0171050883 0.006629228456384328 0.011410767524822413 1.7890299183824534e-06 5.747382396559647 0.059438777322108116 IYPVGYFT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 IYPVGYFTK 9 0 Q2L6G8;G8JLG2;Q15517 Q2L6G8 CDSN Corneodesmosin 1 IYPVGY(0.334)FT(0.666)K 100.07 0.042673 42818000.0 142300.0 125770.0 146150.0 146000.0 152150.0 120140.0 129060.0 123940.0 93772.0 129620.0 True False 134391.53567203388 135416.1545857108 136746.8681160882 126114.54813595187 133035.556761742 136688.1944776646 135061.5457275384 124300.64488062833 112529.02020859336 125877.53380679451 1.06763718360027 1.0757769912584785 1.0863484847580245 1.0018828961927484 1.0568649761277822 1.0858823679169234 1.072959897155597 0.9874728326931913 0.8939563463430308 1.0 16.941661293174974 -7.908640837343068 4.060570508052615 0.9447445272290259 1.0632242492502917 0.6816380282263653 0.033045880246242144 0.11874782493344306 3.61405100807479 0.0197914440727389 0.008744472742553485 1.2341250359041444e-08 7.908640837343068 0.11847972202126578 IYPVTEIQEAHK ddPTM_A459_Selumetinib_30min_R2 1 IYPVTEIQEAHK 12 0 Q53FA7 Q53FA7 TP53I3 Quinone oxidoreductase PIG3 0 132.86 0.0045497 0.0 36308.0 31099.0 34647.0 34419.0 32667.0 26077.0 32553.0 30644.0 23317.0 28856.0 False True 34290.14671243995 33484.1933009542 32417.84974080135 29731.07282391322 28563.07941331467 29668.870046562864 34066.77900254577 30733.1689666127 27981.051531414265 28022.852303108066 1.2236494109001448 1.1948888335410597 1.1568361917678818 1.0609581245452195 1.0192780914791706 1.0587384084122027 1.2156784981794078 1.0967180868738342 0.9985083327263883 1.0 14.774316187356703 -5.561353063122553 2.8325253911711625 1.0724890241272222 1.207889129509004 0.4973651402778717 0.059694597772831454 0.2515064686781695 4.067829635532818 0.018053921480521425 0.03798474319688994 2.7456611386856423e-06 5.561353063122553 0.1354001053817817 IYQY(ph)IQSR ddPTM_A459_Selumetinib_30min_R1 4 IYQYIQSR 8 0 A0A2R8Y6L5;A0A2R8Y6I6;Q13627-5;Q13627-2;Q13627;A0A2R8Y443;A0A2R8YDF3;Q13627-4;Q13627-3;Q9Y463-2;Q9Y463-3;Q9Y463 A0A2R8Y6L5 DYRK1A;DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1A;Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1 IYQY(1)IQSR;IYQY(1)IQSR;IYQY(1)IQSR;IYQY(1)IQSR 215.39 0.0022322 341615000.0 9125.400000000001 10694.3 11697.5 11831.300000000001 11023.5 9480.0 10033.599999999999 9741.0 4984.200000000001 7898.599999999999 True False 9338.004065062583 9442.20638435481 10109.04374976816 9765.185556007002 10026.426371356996 9384.639807151312 9276.7574739023 9482.637036772703 8457.823368435038 8912.462248879283 1.047746829585372 1.0594385839381413 1.1342593626177035 1.0956776346777735 1.1249894912730531 1.0529794735827807 1.0408748126892573 1.0639750017415353 0.9489884088427512 1.0 13.121608345310339 -7.83190074614898 1.1670631298288752 0.9805307455197106 1.0899106094669129 0.5865887839030726 0.03366817481316061 0.3536719730110635 0.8691775317004181 0.03014530045698872 0.011383051802468453 1.472649023829484e-08 7.83190074614898 0.10937986394720223 IYQY(ph)IQSR ddPTM_A459_Selumetinib_30min_R2 3 IYQYIQSR 8 0 A0A2R8Y6L5;A0A2R8Y6I6;Q13627-5;Q13627-2;Q13627;A0A2R8Y443;A0A2R8YDF3;Q13627-4;Q13627-3;Q9Y463-2;Q9Y463-3;Q9Y463 A0A2R8Y6L5 DYRK1A;DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1A;Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1 IYQY(1)IQSR;IYQY(1)IQSR;IYQY(1)IQSR 158.07 0.0072428 196187000.0 107152.0 96273.0 107690.0 104460.0 108288.0 79517.0 86454.0 77141.0 76030.0 101581.0 True False 101196.9208034419 103656.82953351436 100761.34264400674 90232.36779644877 94683.89333299725 90469.74496654299 90474.28230535112 77365.46753861997 91238.12445569431 98648.09259086549 1.0258375823154275 1.0507737839739302 1.0214221075911298 0.9146894321685447 0.9598147399128191 0.9170957348537746 0.9171417300543808 0.7842571052994062 0.9248848311147445 1.0 16.5900035355535 -5.845566939831008 0.981544831944372 0.8959018358298853 1.0536623220513253 0.467485257183863 0.054162679801796336 0.5112188329779502 0.9557119462324986 0.02201796818479083 0.05919926444396831 1.4270298584549248e-06 5.845566939831008 0.15776048622144 IYRS(ph)TPPEVIVEVLEPY(ph)VRLT(ph)T(ph)ANVR ddPTM_A459_Selumetinib_30min_R1 1 IYRSTPPEVIVEVLEPYVRLTTANVR 26 2 E9PGM9;P78332;P78332-2;F8WCA5;F8WF63 E9PGM9 RBM6 RNA-binding protein 6 4 IY(0.426)RS(0.474)T(0.1)PPEVIVEVLEPY(1)VRLT(1)T(1)ANVR 49.106 0.016512 14538000.0 60.523 155.91 223.97 163.76 346.94 240.04 333.96 124.73 0.0 0.0 True False 61.933068142742485 137.6559847194074 193.55610417914713 135.1623901559174 315.5593382572321 237.6254155388818 308.76912832726157 121.42175521986029 0.0 0.0 0.0 IYS(ph)S(ph)Y(ph)PKVQET(ph)LPVTY(ph)K ddPTM_A459_Selumetinib_30min_R1 1 IYSSYPKVQETLPVTYK 17 1 Q9NR99 Q9NR99 MXRA5 Matrix-remodeling-associated protein 5 5 IY(0.131)S(0.896)S(0.935)Y(0.93)PKVQET(0.988)LPVT(0.244)Y(0.876)K 52.823 0.028953 7141400.0 1318.3 1506.5 1282.7 1180.2 1523.9 1406.6 1172.3 1465.5 733.56 1186.4 True False 1349.0138250347384 1330.11827964715 1108.5163853667539 974.1002250977884 1386.0635140663976 1392.450881090615 1083.8724671758553 1426.6301793851128 1244.7977428973963 1338.6859965146214 1.0077148999444279 0.9935999055119886 0.8280630321470958 0.7276540037274896 1.035391060842593 1.0401624314559015 0.8096539965292877 1.0656944071271839 0.9298653650955707 1.0 10.386601885058138 IYS(ph)SDSDEGSEEDKAQR ddPTM_A459_Selumetinib_30min_R2 1 IYSSDSDEGSEEDKAQR 17 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 IYS(0.547)S(0.436)DS(0.017)DEGS(0.001)EEDKAQR 71.929 0.015713 5616900.0 17156.0 15554.0 18104.0 16879.0 19662.0 17391.0 13112.0 15461.0 14081.0 16437.0 True False 16202.53820090943 16746.941786007315 16939.20835014482 14580.051082100925 17191.88377948979 19786.45239022031 13721.733980935092 15505.98895029367 16897.59345601253 15962.421101545167 1.0150426490966975 1.0491479757031472 1.0611929257088137 0.9133984744137323 1.0770223182387797 1.2395646164418614 0.8596273643981754 0.9714058319632155 1.0585858716868983 1.0 13.962391868596269 IYSQS(ph)TLSLSTVANEAHNNLGVK ddPTM_A459_Selumetinib_30min_R1 1 IYSQSTLSLSTVANEAHNNLGVK 23 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 IYS(0.055)QS(0.715)T(0.225)LS(0.004)LSTVANEAHNNLGVK 144.0 4.872800000000001e-07 9616300.0 1739.7 1123.6 1052.3 1192.3 1089.0 985.83 916.14 1382.4 1106.9 731.76 True False 1780.231625133075 992.0483896525312 909.4034398701452 984.0871872429187 990.5001422785657 975.9134452620228 847.0348222114542 1345.734261331956 1878.328455222652 825.6885239460042 2.156057125058811 1.201480171858857 1.1013880095172734 1.191838276424044 1.1996050732846801 1.1819389720933586 1.025852724903375 1.6298328271545168 2.274863221116399 1.0 9.68945384344705 -7.921035454508047 7.252075427266288 1.7400616780123794 1.272800652040105 0.11254134660067727 0.41592330631685515 0.35174605564917455 26.814305379563667 0.22158232019101923 0.10548697833920213 1.199401383595713e-08 7.921035454508047 -0.4672610259722745 IYVDDGLIS(ph)LQVK ddPTM_A459_Selumetinib_30min_R1 2 IYVDDGLISLQVK 13 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 IYVDDGLIS(1)LQVK;IYVDDGLIS(1)LQVK 164.81 0.00036259 11633100.0 2728.3 3137.0 3251.4 3608.6 3376.7 2403.56 2796.8 3032.8 1806.05 2891.23 True False 2791.864081652335 2769.7185816482643 2809.877738661779 2978.4257518114528 3071.2780812048054 2379.382368657868 2585.8351242834015 2952.360292077225 3064.734941327013 3262.3475334650766 0.855783773191993 0.8489955632367682 0.8613054586729727 0.9129700993713388 0.9414319135836126 0.7293466880061751 0.7926301835589162 0.9049803130389971 0.9394262597375176 1.0 11.671694763247672 -8.300302844636077 2.171303095382406 0.9921448382133266 0.851544059791992 0.426134956497095 0.0564995258057789 0.31853575508463416 2.8083391611911446 0.057568659208038324 0.01649954899282068 5.0083786479273815e-09 8.300302844636077 -0.14060077842133456 IYVDDGLISLQVK ddPTM_A459_Selumetinib_30min_R1 2 IYVDDGLISLQVK 13 0 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 240.8 1.0674999999999997e-16 19564700.0 3999.0 2637.3 3097.8 3234.6000000000004 7636.900000000001 3544.3 2884.98 2472.55 2492.61 3554.7999999999997 False True 4092.1689193005495 2328.523689952494 2677.1357749973736 2669.7378309619608 6946.143743404203 3508.6475599669197 2667.363635889276 2406.969942025699 4229.777116968595 4011.0932066842347 1.0202128717630414 0.580520962732094 0.6674329508314828 0.6655885798198382 1.7317333169493272 0.8747359832277094 0.6649966725889795 0.6000782873892421 1.0545197777802662 1.0 11.969779775436491 -4.483873822359958 22.331273985157264 0.8624740687949499 2.1923742538958124 0.017675073299792676 0.3279799211501923 969.642818550162 715824.9398904718 0.08304538340552496 133799.66398370752 3.281906300467496e-05 4.483873822359958 1.3299001851008625 KAAS(ph)EELLEK ddPTM_A459_Selumetinib_30min_R1 3 KAASEELLEK 10 1 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 KAAS(1)EELLEK;KAAS(1)EELLEK;KAAS(1)EELLEK 132.79 0.0042749 49802700.0 4275.889999999999 5004.3 5724.700000000001 5743.9 4599.67 4772.070000000001 5165.9 4621.59 2096.39 3828.17 True False 4375.509917566401 4418.394229564046 4947.317183526201 4740.835691356705 4183.630660637695 4724.067308492886 4776.232003910048 4499.01042015998 3557.4207157324195 4319.5529090335285 1.0129543519228226 1.022882303472614 1.145330845046445 1.0975292561973586 0.9685332599789256 1.0936472843319947 1.1057236951355454 1.0415453902072016 0.8235622506886642 1.0 12.07666628008327 -8.117456944180443 6.724584141413382 0.913547911858621 1.0647515805331242 0.4774254273656724 0.06277192856000888 0.20116852233304602 10.25091920831667 0.04249715887449833 0.01582143910447375 7.630325342194456e-09 8.117456944180443 0.1512036686745032 KAAS(ph)EELLEK ddPTM_A459_Selumetinib_30min_R2 3 KAASEELLEK 10 1 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 KAAS(1)EELLEK;KAAS(1)EELLEK;KAAS(1)EELLEK 78.615 0.026742 55021000.0 248770.0 267109.0 247766.0 250057.0 248631.0 187748.0 210214.0 204668.0 168889.0 250585.0 True False 234944.35930521318 287595.40140919556 231825.00530722382 215998.80522761482 217395.7509906582 213608.5827933462 219989.36753113853 205263.5499953887 202671.5191529367 243349.95995197954 0.9654587958492985 1.1818181579563318 0.9526404087059231 0.8876056740269777 0.8933461547869459 0.8777835132395245 0.9040041246546711 0.8434912010500989 0.8328397473043762 1.0 17.892673011629412 -5.4835781912252815 5.380075729474283 0.8867752009409666 1.0745294602616515 0.5549908900023064 0.06446910457275144 0.12255053568352917 9.055609354601767 0.016049780922214506 0.03288615189395834 3.28414110663155e-06 5.4835781912252815 0.1877542593206849 KAAS(ph)LGSSQSSR ddPTM_A459_Selumetinib_30min_R1 1 KAASLGSSQSSR 12 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;H0YA91;H0Y944;P20810-5;F8W7E0;E9PSG1;D6RGF7;D6RBR1;E7EN75 P20810-6;P20810-5 CAST Calpastatin 1 KAAS(0.907)LGS(0.072)S(0.02)QS(0.001)SR 108.66 0.014305000000000003 4049700.0 1983.9 2470.7 2987.3 3246.8 2382.9 2250.8 2135.1 2109.2 1440.3 2079.2 True False 2030.12101000259 2181.429295402733 2581.641068064322 2679.807329984322 2167.3671157351646 2228.158995562887 1974.0476880211281 2053.257164352837 2444.0839046500923 2346.0855731230613 0.86532266054564 0.9298165933900094 1.1004036245053475 1.142246199663134 0.9238227030440367 0.9497347501254215 0.8414218605817162 0.8751842592082364 1.0417709961860333 1.0 11.196039921075707 KAAS(ph)LTEDRDR ddPTM_A459_Selumetinib_30min_R1 2 KAASLTEDRDR 11 2 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 KAAS(0.65)LT(0.35)EDRDR;KAAS(0.992)LT(0.008)EDRDR 88.163 0.035079 199837000.0 10469.5 12814.0 14509.0 16572.4 15422.099999999999 12938.5 14756.8 13440.0 7453.3 11514.400000000001 True False 10713.41897989926 11313.73092293302 12538.7574922322 13678.341442476352 14027.173777992903 12808.35043721806 13643.682695232153 13083.527540727353 12647.705732506089 12992.385399753843 0.8245921476515189 0.8707970534146389 0.9650850945716067 1.0527967745426876 1.079645757603424 0.9858351675328789 1.0501291545346747 1.007015042901609 0.973470640175569 1.0 13.665378713218649 -5.301678230185799 2.330372399787762 1.0234291450604374 0.8318232764598434 0.8246088059325961 0.0317965653181231 0.12334732554636979 1.2640942443636147 0.00913448087878698 0.02974929966397028 4.992542491246299e-06 5.301678230185799 -0.19160586860059392 KAAS(ph)LTEDRDR ddPTM_A459_Selumetinib_30min_R2 2 KAASLTEDRDR 11 2 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 KAAS(0.983)LT(0.017)EDRDR;KAAS(0.869)LT(0.131)EDRDR 119.17 0.005762399999999999 128734000.0 173684.0 157525.0 179422.0 171906.0 175493.0 96093.0 130947.0 139272.0 106208.0 152200.0 True False 164031.33859214006 169606.66097729202 167878.18385990302 148492.10624560903 153446.00041267424 109328.93850459659 137036.294966558 139677.25846227934 127452.56769946573 147805.5905369093 1.1097776342308172 1.1474982804181462 1.1358040196590622 1.0046447208539673 1.038161004974683 0.7396806718031108 0.9271387805344071 0.9450065992422648 0.8622986940919457 1.0 17.173341312847406 -6.174576891619682 1.6806924604776154 0.8978231865409492 1.1316713174272912 0.6298828139359322 0.07400633163644797 0.2279103363446621 1.2765981346583184 0.02554240009817911 0.03672634180485848 6.689953642669904e-07 6.174576891619682 0.23384813088634204 KAAS(ph)PSPQSVR ddPTM_A459_Selumetinib_30min_R1 4 KAASPSPQSVR 11 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KAAS(0.972)PS(0.026)PQS(0.002)VR;KAAS(0.985)PS(0.015)PQS(0.001)VR;KAAS(0.967)PS(0.027)PQS(0.005)VR;KAAS(0.953)PS(0.043)PQS(0.004)VR 120.6 0.008409100000000001 117991000.0 5216.41 5958.59 6853.540000000001 7181.38 5829.889999999999 5810.79 5598.4 5214.93 3013.6299999999997 4477.2 True False 5337.942203633052 5260.95551272666 5922.86691180047 5927.286794198232 5302.577478850674 5752.3387283751845 5176.108180702299 5076.613115920035 5113.910003173407 5051.892231621092 1.056622342460415 1.0413831632822623 1.172405633423398 1.1732805298374778 1.0496220496669504 1.1386503244011854 1.024588004530997 1.004893391063295 1.0122761469779837 1.0 12.302608148141443 -7.375384936019491 5.169658084659358 1.0081349638210235 1.1058284773487463 0.5217236654777948 0.044682346005657604 0.2042260738806786 7.927671253762902 0.020546413055644315 0.013614920501887146 4.21322899197493e-08 7.375384936019491 0.09769351352772282 KAAS(ph)PSPQSVR ddPTM_A459_Selumetinib_30min_R2 1 KAASPSPQSVR 11 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KAAS(0.818)PS(0.175)PQS(0.007)VR 115.37 0.011127 33906000.0 9940.9 12347.0 9685.6 12818.0 10628.0 6405.0 7652.7 8018.8 5514.9 9492.0 True False 9388.42457457569 13293.975198137614 9062.439040883934 11072.16628771667 9292.81562447449 7287.230611198954 8008.565713537373 8042.133380416196 6618.034099180703 9217.94129682221 1.0184947237418678 1.4421848404177378 0.9831304788204842 1.2011539161714648 1.0081226735169264 0.7905486026159824 0.8688019868707825 0.872443544762933 0.7179514260372002 1.0 13.17022886476308 -6.512753634742271 3.210965505175997 0.8435942840871014 1.1679034055846422 0.5445506060958053 0.13372707572801848 0.17989758297054628 3.833846397510846 0.04310588483036709 0.04616795815233933 3.0707634677890974e-07 6.512753634742271 0.3243091214975409 KAASPSPQS(ph)VR ddPTM_A459_Selumetinib_30min_R2 1 KAASPSPQSVR 11 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KAAS(0.295)PS(0.029)PQS(0.676)VR 103.43 0.023879 33689000.0 5593.4 6969.5 5966.0 5964.4 7135.1 5723.3 3911.6 4622.6 3708.9 5429.5 True False 5282.541220154277 7504.038239525394 5582.154055289661 5152.038430836112 6238.724949396684 6511.632624055424 4093.497150688358 4636.051000687373 4450.783635324538 5272.736227464834 1.0018595644209112 1.4231772491174632 1.0586825918226517 0.97710907744635 1.1832044464694005 1.2349627106581547 0.776351589401721 0.879249558614165 0.8441127041669794 1.0 12.364336111297009 -7.261120964563485 24.999998109245325 0.8648659212232839 1.1490527432150615 0.5097228283996017 0.13031574981691724 23.674446533109446 1858877.2231934282 0.05214920285095248 0.03784312737224832 5.481242739451069e-08 7.261120964563485 0.2841868219917776 KADTTTPTPTAILAPGS(ph)PASPPGSLEPK ddPTM_A459_Selumetinib_30min_R1 3 KADTTTPTPTAILAPGSPASPPGSLEPK 28 1 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;H0YDJ7;U3KPW0;E9PIQ3;U3KQA6;A0A0G2JHL0;A0A140T9F7;A0A140T9V2 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 KADTTTPTPTAILAPGS(0.998)PAS(0.002)PPGSLEPK;KADTTTPTPTAILAPGS(0.777)PAS(0.222)PPGS(0.001)LEPK;KADTTTPTPTAILAPGS(0.974)PAS(0.026)PPGSLEPK 192.3 4.4871e-33 92142000.0 9756.2 11327.900000000001 11874.699999999999 13942.0 11634.2 9664.5 10541.3 11184.1 5903.599999999999 9380.2 True False 9983.50047773944 10001.624201802166 10262.180963058081 11507.291423753053 10581.888664184838 9567.283904663907 9746.161254150682 10887.461336923263 10017.978018115868 10584.24004088541 0.9432420692628476 0.9449544004262297 0.9695718278701861 1.0872099819450454 0.9997778417069635 0.9039178880776375 0.920818236973335 1.0286483767248809 0.9464995105381063 1.0 13.369630065653961 -8.681303637222625 0.0033789815979800384 1.5252973355855814 0.4321221877561023 0.011880831963638538 0.05207742785598369 175578.08436483046 333.8752870973429 54315.93229798842 53691.91292588861 2.083034019508377e-09 8.681303637222625 -1.093175147829479 KADTTTPTPTAILAPGSPAS(ph)PPGSLEPK ddPTM_A459_Selumetinib_30min_R2 2 KADTTTPTPTAILAPGSPASPPGSLEPK 28 1 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;H0YDJ7;U3KPW0;E9PIQ3;U3KQA6;A0A0G2JHL0;A0A140T9F7;A0A140T9V2 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 KADTTTPTPTAILAPGS(0.019)PAS(0.979)PPGS(0.001)LEPK;KADTTTPTPTAILAPGS(0.004)PAS(0.99)PPGS(0.006)LEPK 154.45 2.3039000000000002e-15 22917000.0 181052.0 175810.0 172736.0 174764.0 173971.0 139019.0 148628.0 149131.0 127146.0 165730.0 True False 170989.85464858098 189294.0616817507 161622.353820737 150960.84171528404 152115.2076595269 158167.60536116612 155539.49650079466 149564.94652003387 152578.7527560663 160944.944281747 1.0624120901197713 1.1761417081258314 1.004208951961884 0.9379657272801002 0.9451381547794198 0.9827435466645107 0.9664143051832079 0.9292926049184153 0.9480183017676217 1.0 17.296207732990766 -5.440892547948774 4.726113541388728 0.9570607168076908 1.1175430683944128 0.7910573814732924 0.032546585504670086 0.083116822818275 3.2591070433566296 0.008196220831870521 0.017487589062301974 3.623326347589733e-06 5.440892547948774 0.16048235158672197 KADTTTPTTS(ph)AITASR ddPTM_A459_Selumetinib_30min_R1 1 KADTTTPTTSAITASR 16 1 Q15059;Q15059-2 Q15059 BRD3 Bromodomain-containing protein 3 1 KADT(0.001)T(0.009)T(0.186)PT(0.276)T(0.108)S(0.414)AIT(0.004)AS(0.003)R 61.56100000000001 0.035241 4742400.0 1534.1 1655.7 1711.1 2290.9 1825.0 1642.7 1999.2 1747.9 894.62 1243.2 True False 1569.8415451610338 1461.8498742859533 1478.742018399511 1890.8373205189994 1659.9290722299188 1626.175929452264 1848.3987344348452 1701.540014020635 1518.1047995404192 1402.7768297934729 1.1190957191616555 1.0421115057205341 1.0541534383749567 1.3479245453443813 1.1833165739373566 1.1592549113401607 1.3176712754137663 1.2129798396165044 1.0822140537949474 1.0 10.454069791011216 KAEAAAAPTVAPGPAQPGHVS(ph)PTPATTSPGEK ddPTM_A459_Selumetinib_30min_R2 2 KAEAAAAPTVAPGPAQPGHVSPTPATTSPGEK 32 1 Q9Y6R0;A0A0C4DGH3;M0QYC2 Q9Y6R0 NUMBL Numb-like protein 1 KAEAAAAPTVAPGPAQPGHVS(0.677)PT(0.19)PAT(0.053)T(0.064)S(0.016)PGEK;KAEAAAAPTVAPGPAQPGHVS(0.767)PT(0.159)PAT(0.045)T(0.013)S(0.017)PGEK 87.772 1.6564e-07 13305300.0 114525.0 96057.0 116997.0 118521.0 126169.0 107084.0 119599.0 120763.0 105888.0 109272.0 True False 108160.15897989922 103424.26302806365 109469.5403967019 102378.23533987097 110318.52225482892 121833.8489882324 125160.59048092253 121114.40033660908 127068.55875791906 106117.03343724771 1.019253511679251 0.9746245223602445 1.0315925431654354 0.9647672199620273 1.039592972791364 1.1481083200490978 1.1794580608487912 1.1413285540839215 1.1974379102207096 1.0 16.695296724309486 -6.661079872293956 3.7449677856772534 1.1454243035565335 0.9986412096412125 0.5903528417701196 0.053340086014869406 0.14163579617092012 3.7916253527035426 0.01716971718127563 0.01693509500308901 2.1823285168869285e-07 6.661079872293956 -0.14678309391532096 KAEAGAGS(ph)ATEFQFR ddPTM_A459_Selumetinib_30min_R1 2 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 KAEAGAGS(0.939)AT(0.061)EFQFR;KAEAGAGS(0.827)AT(0.173)EFQFR 133.87 0.00089853 25040000.0 3785.6 4303.4 5601.7 5749.5 4702.9 4561.4 3961.5 3959.8 2539.7 3290.2000000000003 True False 3873.797114504666 3799.555927403618 4841.019907935565 4745.457756481725 4277.523525364434 4515.516457419828 3662.680865578054 3854.7732407568546 4309.685407651073 3712.5292192619722 1.043438821816129 1.023441353051208 1.3039681634877287 1.278227719221855 1.1521858206990163 1.216291156441722 0.9865729397023231 1.0383145863894803 1.160848885792153 1.0 11.858186665274065 -7.255759003252949 24.92358389884766 1.0496269845707757 1.1732037353312752 0.2904661551095137 0.09414472642873457 654.7256640546253 2872722.768331848 0.039804434481625996 0.029948741664182092 5.549335687813666e-08 7.255759003252949 0.12357675076049945 KAEAGAGS(ph)ATEFQFR ddPTM_A459_Selumetinib_30min_R2 4 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 KAEAGAGS(0.633)AT(0.367)EFQFR;KAEAGAGS(0.623)AT(0.377)EFQFR;KAEAGAGS(0.854)AT(0.146)EFQFR;KAEAGAGS(0.657)AT(0.343)EFQFR 103.73 0.0028057 66603000.0 156220.0 154287.0 155534.0 165604.0 159662.0 118816.0 104523.0 101646.0 78632.0 151314.0 True False 147537.91779820898 166120.31678910344 145527.11177261517 143048.44951716592 139603.83216360986 135181.82549574005 109383.52660839526 101941.77303159874 94360.59716164865 146945.17165901346 1.0040337911923434 1.130491835244413 0.9903497347317481 0.9734817952992025 0.9500402809257374 0.9199473788048629 0.744383264679291 0.6937402017410603 0.6421483339419453 1.0 17.164918429968843 -6.929865403715674 1.4153538984675444 0.7406165866589823 1.0299867040812078 0.5590520793132772 0.09925660694614512 0.27487372953049194 1.1322841245478543 0.04860912320786144 0.03798429496133668 1.17526173491261e-07 6.929865403715674 0.2893701174222255 KAEDS(ph)DSEPEPEDNVR ddPTM_A459_Selumetinib_30min_R1 5 KAEDSDSEPEPEDNVR 16 1 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 KAEDS(0.982)DS(0.018)EPEPEDNVR;KAEDS(0.998)DS(0.002)EPEPEDNVR;KAEDS(0.987)DS(0.013)EPEPEDNVR;KAEDS(0.986)DS(0.014)EPEPEDNVR;KAEDS(0.973)DS(0.027)EPEPEDNVR 185.28 2.1214000000000002e-13 41879900.0 8777.589999999998 9087.529999999999 10652.68 10659.12 8855.18 8285.88 8608.65 8399.46 4978.790000000001 7629.39 True False 8982.09076878303 8023.557762921923 9206.104566982704 8797.704788463261 8054.230532509012 8202.531570177098 7959.2925996361255 8176.679035508758 8448.642993565803 8608.696523051822 1.0433740746617512 0.9320293428205941 1.0693958768706946 1.0219555033570211 0.9355923409475412 0.9528192274187943 0.9245641983456191 0.9498161555136443 0.9814079252233556 1.0 13.071579094631437 -6.255785391758083 24.847254027934078 0.9529899557997701 1.0144064037468774 0.3588995557030269 0.03852825738927426 476.9490740037229 2096018.8204920485 0.011294375393469348 0.014159124293978594 5.548998510551365e-07 6.255785391758083 0.06141644794710732 KAEDS(ph)DSEPEPEDNVR ddPTM_A459_Selumetinib_30min_R2 4 KAEDSDSEPEPEDNVR 16 1 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 KAEDS(0.995)DS(0.005)EPEPEDNVR;KAEDS(0.976)DS(0.024)EPEPEDNVR;KAEDS(0.979)DS(0.021)EPEPEDNVR;KAEDS(0.998)DS(0.002)EPEPEDNVR 154.46 5.8173e-05 79649000.0 202727.0 182891.0 180705.0 190636.0 182714.0 143922.0 156045.0 155755.0 135454.0 162392.0 True False 191460.24492048076 196918.15161274734 169078.63703672754 164671.0479345573 159759.8338361152 163745.94910616335 163301.4016973015 156208.22126337152 162548.58490098143 157703.32101491277 1.214053348327242 1.2486620468450778 1.0721311127033215 1.0441824996125837 1.0130403900689444 1.0383164289271953 1.0354975446703458 0.9905195417450983 1.030723917891434 1.0 17.26685351605729 -5.37719807096989 2.985034083849405 1.0230490051064305 1.2347323495648752 0.9474744803056551 0.019382614820330643 0.05103182349915211 0.8581630215303272 0.005361131843489867 0.013438338721798823 4.195675859514181e-06 5.37719807096989 0.21168334445844472 KAEFPSSGSNSVLNTPPT(ph)TPESPSSVTVTEGSR ddPTM_A459_Selumetinib_30min_R2 1 KAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSR 33 1 Q4LE39-2;Q4LE39;H0Y7Y8;H7C5R6;Q4LE39-4;Q4LE39-3 Q4LE39-2 ARID4B AT-rich interactive domain-containing protein 4B 1 KAEFPSSGSNSVLNTPPT(0.831)T(0.16)PES(0.009)PSSVTVTEGSR 176.52 3.2201e-41 6288100.0 53152.0 55393.0 59728.0 66111.0 60949.0 46637.0 43868.0 55029.0 37177.0 53828.0 True False 50198.024624314436 59641.46498343212 55885.16550692943 57106.56775216385 53292.04172902669 53060.82342146539 45907.94892279295 55189.12527945866 44613.43881217084 52273.84577806003 0.960289488503315 1.1409427428900663 1.0690846383141972 1.0924500943477966 1.01947811445306 1.015054902345365 0.8782202311592899 1.055769371049838 0.8534562198003738 1.0 15.673801681583765 -6.78681698311815 2.0248444875033407 0.9516796622119015 1.0696085582955883 0.3526917462023035 0.06924078502421172 0.33684326711373 2.8429040069715525 0.026194369817414527 0.02364949932516877 1.6337402805158151e-07 6.78681698311815 0.11792889608368684 KAEGAATEEEGT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KAEGAATEEEGTPK 14 1 P80723;P80723-2;U3KQP0 P80723 BASP1 Brain acid soluble protein 1 1 KAEGAATEEEGT(1)PK 100.69 0.011003 5441600.0 4446.0 5409.0 3949.2 3986.3 4114.2 4360.3 4559.5 4830.3 3223.0 5301.1 True False 4549.583149589959 4775.711765424123 3412.920331402814 3290.1675371185515 3742.071336421008 4316.439340835638 4215.573244125488 4702.184752974354 5469.195601393629 5981.547822086696 0.7606029885426565 0.7984073533258301 0.5705747797920636 0.5500528684180541 0.6256025108757829 0.7216258181364542 0.7047629425547017 0.7861150479499085 0.9143445415915222 1.0 12.546303138033087 -8.170782604973313 1.202760269672213 1.0010715513635207 0.6634912792408753 0.7094872643985937 0.07297454874902082 0.2721941053120426 0.7506593450069748 0.07675880424355142 0.025357244216396204 6.748657610848538e-09 8.170782604973313 -0.3375802721226454 KAEGAATEEEGT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 KAEGAATEEEGTPK 14 1 P80723;P80723-2;U3KQP0 P80723 BASP1 Brain acid soluble protein 1 1 KAEGAATEEEGT(1)PK;KAEGAATEEEGT(1)PK 116.29 0.0033350000000000003 38156000.0 108294.0 67598.0 81675.0 72370.0 50751.0 55767.0 126321.0 83171.0 54562.0 65546.0 True False 102275.45301523004 72782.5492381717 76420.11942101626 62513.08115478669 44375.20566030343 63448.39804757721 132195.17680031285 83413.0138402998 65475.924589656686 63653.516671039695 1.6067525937928593 1.1434175681810432 1.2005639816564129 0.9820836997561854 0.6971367487775066 0.9967775759425432 2.0767929835439465 1.310422710364564 1.028630121538063 1.0 15.957952600568765 KAEGEPQEES(ph)PLK ddPTM_A459_Selumetinib_30min_R1 8 KAEGEPQEESPLK 13 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK 157.7 6.2458e-05 2140898400.0 67181.6 103234.09999999999 58628.72 62145.01000000001 50207.53 59996.31 67283.6 65723.51 39354.28999999999 70670.09999999999 True False 68746.80056736225 91147.40357976886 50667.26184850673 51292.55060981551 45666.26777635936 59392.801593690914 62208.34388166284 63980.309014752114 66781.35580638192 79741.29572006743 0.8621229432827195 1.1430389079673684 0.6353955173537013 0.6432369846343918 0.572680282706607 0.7448186169709344 0.7801270761895546 0.8023485000714761 0.8374751777400069 1.0 16.283039427494778 -10.50224925057997 15.938821767132557 0.9999924386521504 0.7760405334327659 0.1607596061362222 0.15044235290621846 0.0 0.0 0.15890260007374613 0.03853954142878447 3.145942274591615e-11 10.50224925057997 -0.22395190521938446 KAEGEPQEES(ph)PLK ddPTM_A459_Selumetinib_30min_R2 8 KAEGEPQEESPLK 13 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK;KAEGEPQEES(1)PLK 129.05 0.00090571 1810091000.0 1672783.0 1286612.0 1483404.0 1441373.0 1382767.0 1209774.0 1636999.0 1577429.0 1107596.0 1275610.0 True False 1579816.4175409127 1385291.0032903743 1387963.4016481554 1245055.5108928874 1209051.447366177 1376409.387265044 1713122.6971519827 1582019.0572325713 1329146.1488179548 1238779.8248671903 1.2753004091831128 1.1182705558180135 1.1204278385765276 1.0050660221451135 0.9760018875798204 1.1111009072274882 1.3829113638782797 1.2770784811596199 1.072947849276164 1.0 20.240488361484687 -7.028214137451533 24.70452650463831 1.2121359992175578 1.0908033421742789 0.07599597751838316 0.12407991890481494 1141.9554694216984 999901.9630600571 0.04818449459681531 0.037414858900553766 9.37099837455122e-08 7.028214137451533 -0.12133265704327889 KAEGEPQEES(ph)PLKSK ddPTM_A459_Selumetinib_30min_R2 4 KAEGEPQEESPLKSK 15 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KAEGEPQEES(0.999)PLKS(0.001)K;KAEGEPQEES(0.987)PLKS(0.013)K;KAEGEPQEES(0.913)PLKS(0.087)K;KAEGEPQEES(0.995)PLKS(0.005)K 112.56 0.0033663000000000005 137802000.0 263948.0 305877.0 243155.0 266042.0 212197.0 172944.0 136210.5 140135.0 94149.9 253530.0 True False 249278.82682756142 329336.78235042875 227510.67202714723 229806.62065195155 185538.91579475088 196765.4661706778 142544.55814598533 140542.7696494019 112982.51076800171 246209.93014995052 1.0124645528136977 1.3376259119599727 0.9240515680605783 0.9333767346913718 0.7535801487850272 0.7991776207029534 0.5789553575648662 0.570824944240902 0.45888689663813065 1.0 17.909529424273735 -6.018710966249394 0.9260238775005684 0.6311030784088854 1.184804628085286 0.5609709328821427 0.16413646889277902 0.4162298540423949 0.7255560988316582 0.07082730415608636 0.15464961108480954 9.578313197217826e-07 6.018710966249394 0.5537015496764006 KAEGEPQEESPLKS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KAEGEPQEESPLKSK 15 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KAEGEPQEES(0.01)PLKS(0.99)K 82.865 0.027776 435440000.0 3421.6 3086.6 5550.0 5069.1 3811.4 3574.5 3188.4 3288.3 2319.0 2732.1 True False 3501.3166227253705 2725.2194370785887 4796.340483967792 4183.876843791896 3466.6595429573226 3538.543775386323 2947.896421004434 3201.0836020962597 3935.1736269413072 3082.7916479076175 1.1357616805215554 0.8840102570435716 1.555843219966945 1.3571714606894105 1.124519571509235 1.147837473151336 0.9562425092870805 1.0383716993228946 1.2764967848580446 1.0 11.590021672100063 -6.595341600033591 3.0504172135199683 1.0770247211543906 1.2311746335278255 0.13056520509867064 0.17879516649140176 0.580028848806586 10.93448899190147 0.06646109375507414 0.06768093823291021 2.538974855886841e-07 6.595341600033591 0.1541499123734349 KAELMGISTDIFPVDNSDTSS(ph)SVDGR ddPTM_A459_Selumetinib_30min_R1 1 KAELMGISTDIFPVDNSDTSSSVDGR 26 1 A0A0U1RRH6;O94880;O94880-2;B4DG57 A0A0U1RRH6 PHF14 PHD finger protein 14 1 KAELMGISTDIFPVDNS(0.009)DT(0.092)S(0.197)S(0.422)S(0.279)VDGR 132.22 2.8157e-09 8898300.0 4402.4 5337.9 5459.1 5791.8 5158.3 4732.3 5371.5 4895.8 2969.0 4108.4 True False 4504.967354420788 4712.936186477614 4717.784204689834 4780.370855551069 4691.732675771832 4684.697358584615 4966.32343038054 4765.947480200368 5038.176152819638 4635.753159204881 0.9717875822347442 1.0166495118747805 1.0176953005623413 1.0311961597996286 1.0120756033905292 1.0105579822088995 1.0713088596012215 1.0280848260302577 1.0868085464852018 1.0 12.17858803360528 -1.6755575208134212 0.4234988623987269 1.0417115249581224 1.3729099893363709e-08 0.3501778077678993 0.02544888462376897 77.30400093984684 1.121960564413697 0.016742400428735833 67.36001973944055 0.02110777612044483 1.6755575208134212 -1.0417115112290225 KAEPS(ph)EVDMNSPK ddPTM_A459_Selumetinib_30min_R1 1 KAEPSEVDMNSPK 13 1 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KAEPS(0.929)EVDMNS(0.071)PK 156.96 0.00065558 30331000.0 2725.1 4501.2 4489.8 4732.2 2398.7 3487.4 2859.9 2572.4 2093.5 3238.4 True False 2788.5895278784515 3974.1974114488926 3880.1098207060513 3905.810104395657 2181.7380085248824 3452.3199223058523 2644.1754404813 2504.1715956671906 3552.516596809671 3654.0801846872478 0.7631440436267073 1.0876054193071967 1.061856780528791 1.0688900918932502 0.597069001842831 0.9447849384294056 0.7236227194909284 0.68530833180978 0.9722054298908961 1.0 11.835292577297817 -6.228987866597284 24.990710778403738 0.8061342908921454 1.0067108172228916 0.24374963588560217 0.14909024303525867 818.8904727148245 630622.4797359975 0.042245522367884605 0.05453440310279941 5.902175695534123e-07 6.228987866597284 0.20057652633074619 KAEPSEVDMNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 5 KAEPSEVDMNSPK 13 1 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK 111.83 0.0030581 436304100.0 37527.399999999994 59176.6 62068.1 69834.6 38646.799999999996 50436.1 44593.1 39853.1 28621.0 42462.1 True False 38401.715404390954 52248.17616154503 53639.59293566868 57639.29806779705 35151.20376364673 49928.75862631481 41229.40656488922 38796.066326887 48567.74660486723 47912.52415087952 0.8014963954614781 1.0904909955695983 1.1195317693293358 1.2030110934311729 0.7336537656198909 1.0420815749361492 0.8605141827855959 0.8097270393168134 1.0136753900070965 1.0 15.548115199783076 -6.254949468189139 24.990958089068585 0.9045639329408102 1.060972383358486 0.2224236924272568 0.1311001602829415 757.2916193197863 2916130.873880443 0.03860831794544746 0.048667466285993 5.559689426031851e-07 6.254949468189139 0.15640845041767593 KAEPSEVDMNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 7 KAEPSEVDMNSPK 13 1 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK;KAEPS(0.039)EVDMNS(0.961)PK;KAEPSEVDMNS(1)PK;KAEPSEVDMNS(1)PK 142.88 0.00038617 462730400.0 1026815.0 1019248.0 906795.0 852337.0 789478.0 716329.2 852500.0 784744.6 564573.0 857817.0 True False 969748.7329661236 1097421.0442011289 848452.7969437476 736247.2302366627 690296.7156171304 814997.0451109529 892142.9391967019 787028.0768645372 677503.3754876317 833049.5943337675 1.1640948384851941 1.3173537946186658 1.0184901387801513 0.883797597699423 0.828638199108897 0.9783295624346925 1.070936166663876 0.9447553689693156 0.8132809620169923 1.0 19.66804286122757 -5.418322073003003 4.366241289203458 0.9334258034397769 1.2376499261166025 0.6920023371681281 0.08122934255373129 0.1252572437474348 3.9538914639400695 0.02273617650363746 0.049434325785754255 3.816611257827458e-06 5.418322073003003 0.30422412267682564 KAEQGS(ph)EEEGEGEEEEEEGGESK ddPTM_A459_Selumetinib_30min_R1 6 KAEQGSEEEGEGEEEEEEGGESK 23 1 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK 116.57 5.543300000000002e-06 373468200.0 21719.95 32679.600000000002 22839.750000000004 25149.980000000003 20119.97 25214.94 28112.030000000002 24015.04 13025.59 24836.809999999998 True False 22225.982575334325 28853.457239666135 19738.237399766367 20758.008116594534 18300.122265969207 24961.300596933743 25991.516943974806 23378.08312735631 22103.47487854695 28024.85649451643 0.7930810485928176 1.029566636507553 0.7043118098973499 0.7406998897802104 0.6529961097053238 0.8906843323825003 0.9274451396052829 0.8341910022601063 0.7887096543338908 1.0 14.774419365062593 KAEQGS(ph)EEEGEGEEEEEEGGESK ddPTM_A459_Selumetinib_30min_R2 6 KAEQGSEEEGEGEEEEEEGGESK 23 1 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK;KAEQGS(1)EEEGEGEEEEEEGGESK 121.76 5.408099999999998e-06 612769000.0 309625.0 259923.0 277898.0 262211.0 257033.0 231078.0 290677.0 288259.0 219685.7 254249.0 True False 292417.28202707967 279858.2583158269 260018.3452324649 226497.40946079578 224742.21663582523 262906.89698276867 304194.0564655488 289097.78596615355 263628.9785313207 246908.17075176528 1.1843159387425375 1.1334507783348682 1.0530973699281918 0.9173346057004734 0.910225919018998 1.0647962608215509 1.2320129201855259 1.1708716851529573 1.0677207551643402 1.0 17.913615053760786 -7.014140028239434 24.689595775661303 1.1342497909961504 1.0337089417112693 0.11455614486019783 0.09754269178339156 1069.8424622275613 1868025.8278404754 0.03960732962342859 0.03197593257486824 9.679657077234143e-08 7.014140028239434 -0.10054084928488116 KAEQGS(ph)EEEGEGEEEEEEGGESKADDPYAHLSK ddPTM_A459_Selumetinib_30min_R1 1 KAEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 33 2 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KAEQGS(0.997)EEEGEGEEEEEEGGES(0.003)KADDPYAHLSK 46.247 0.006950700000000001 21782000.0 558.61 511.18 969.84 1125.6 1188.8 1038.9 807.56 637.23 152.03 239.09 True False 571.6245261341534 451.3308079588653 838.1410549497882 929.035090128851 1081.2732498996868 1028.4496092457275 746.6450990297141 620.3285903852449 257.983806168127 269.7795304338172 2.1188580364676164 1.6729616484731284 3.106762969014073 3.443682656852884 4.007988479188739 3.8121854819449643 2.767612123236616 2.299390874421531 0.9562764296953066 1.0 8.075637077490333 -8.090250711530834 2.265515982716628 0.9196251402346065 3.0358613685777627 0.5846840037438227 0.670516655127294 0.2586026376526105 2.386734765706561 0.6735931391603159 0.21410892052877156 8.123614170123396e-09 8.090250711530834 2.116236228343156 KAEQGS(ph)EEEGEGEEEEEEGGESKADDPYAHLSK ddPTM_A459_Selumetinib_30min_R2 3 KAEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 33 2 Q5STZ8;Q8NE71 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KAEQGS(0.998)EEEGEGEEEEEEGGES(0.001)KADDPYAHLSK;KAEQGS(1)EEEGEGEEEEEEGGESKADDPYAHLSK;KAEQGS(0.991)EEEGEGEEEEEEGGES(0.008)KADDPYAHLSK 74.733 5.0024e-06 19809000.0 23129.2 24086.5 29946.2 34978.8 27412.6 17858.2 11941.29 16511.1 9064.3 36618.2 True False 21843.771657523568 25933.85709969561 28019.4940949573 30214.627098204382 23968.784116246654 20318.004949400965 12496.583646217246 16559.144567440246 10877.413277702883 35560.93742049041 0.6142630999636435 0.7292793435966167 0.7879290065849701 0.8496577787287055 0.6740200302603865 0.5713574057160152 0.35141322340441583 0.4656554570436823 0.30588094878048006 1.0 15.118005735046355 -6.78048469965482 2.886701833898053 0.4848657539067227 0.7470597933700918 0.19770946820294588 0.1868144813931697 0.32612189782672063 5.579637897348869 0.0659106456710902 0.060544274646945326 1.6577357384249714e-07 6.78048469965482 0.26219403946336906 KAGLAS(ph)PEEEDAVGKEPLK ddPTM_A459_Selumetinib_30min_R1 1 KAGLASPEEEDAVGKEPLK 19 2 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 1 KAGLAS(1)PEEEDAVGKEPLK 106.58 0.00092249 21807000.0 2623.8 2877.2 3243.3 3325.2 2582.5 2611.5 2353.6 2504.3 1628.4 2391.9 True False 2684.9294349739403 2540.33608642601 2802.877674171665 2744.516241734591 2348.9133309774065 2585.2306810522823 2176.066057105769 2437.8778288871654 2763.27586636965 2698.9236640789954 0.994814885173927 0.941240436043565 1.0385168396854765 1.0168928740973318 0.8703148452251503 0.9578746948126409 0.8062718060787943 0.903277799714683 1.0238436541007596 1.0 11.398168457090378 -6.248839249601828 24.632420462518073 0.9176086339825764 0.996725173474653 0.2250617709726107 0.06306268735361328 899.7694698456318 1758989.036900672 0.0187534748405398 0.024039752237903538 5.638463201119945e-07 6.248839249601828 0.07911653949207653 KAGSEPETS(ph)RPSPLGSYSPIR ddPTM_A459_Selumetinib_30min_R1 1 KAGSEPETSRPSPLGSYSPIR 21 2 Q8N2Y8 Q8N2Y8 RUSC2 Iporin 1 KAGS(0.001)EPET(0.136)S(0.735)RPS(0.038)PLGS(0.038)Y(0.032)S(0.019)PIR 73.918 0.0039091 11757000.0 1607.0 1761.2 2283.1 2293.0 1502.0 1578.4 1561.8 1863.2 1258.1 1489.0 True False 1644.4399733223272 1554.9978852403326 1973.0675601706057 1892.5705949408807 1366.1443651996383 1562.5227290725352 1443.992168587607 1813.7818834734528 2134.903812011582 1680.1276540882257 0.9787589468698642 0.9255236537870102 1.1743557433684129 1.1264445236263574 0.8131193852297013 0.9300023871819951 0.859453842732703 1.079550044343362 1.2706795265328543 1.0 10.71435513607297 -7.992785022283677 24.32119637345904 1.1485981192380827 0.9761222963587719 0.2396612923273742 0.11989755638025071 162.81890958638178 548851.4741881026 0.06897143881150941 0.03300937864354376 1.016751865057443e-08 7.992785022283677 -0.17247582287931085 KAGTATS(ph)PAGSSPAVAGGTQR ddPTM_A459_Selumetinib_30min_R2 2 KAGTATSPAGSSPAVAGGTQR 21 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KAGT(0.063)AT(0.044)S(0.885)PAGS(0.007)S(0.001)PAVAGGTQR;KAGT(0.034)AT(0.087)S(0.854)PAGS(0.017)S(0.008)PAVAGGTQR 86.084 0.00054169 7572600.0 15824.4 12670.8 16257.3 20259.6 22157.2 16838.2 16597.8 18648.8 18960.2 16898.2 True False 14944.943198092287 13642.609616956503 15211.323017609888 17500.207530240645 19373.61444811876 19157.509208039082 17369.63058791676 18703.064920524954 22752.76979225117 16410.305059203656 0.9107047763082547 0.8313440589762283 0.9269372484382108 1.0664157349363668 1.1805761305609088 1.1674072565332763 1.0584587261024174 1.1397146398588984 1.3864927988947022 1.0 14.002314437615553 -5.82450443261627 2.2963437481464966 1.157904338085749 0.8704060368235976 0.6077859960966236 0.09590023361766661 0.19444159787738008 2.0909851963856774 0.028752988322661828 0.05106584393263686 1.4979439642375154e-06 5.82450443261627 -0.28749830126215137 KAGTQIENIDEDFR ddPTM_A459_Selumetinib_30min_R2 2 KAGTQIENIDEDFR 14 1 O43707;F5GXS2;O43707-3;K7EP19 O43707 ACTN4 Alpha-actinin-4 0 ; 122.63 0.0023626 7595400.0 48728.0 43321.0 55524.0 51326.0 57795.0 44118.0 46825.0 49158.0 43062.0 44327.0 False True 46019.89283363926 46643.58140103015 51951.64628996029 44335.31025771146 50534.275406144436 50194.85403667064 49002.45528197726 49301.04164145498 51675.60325280958 43047.16433462267 1.0690574755611866 1.0835459692176492 1.2068540888342738 1.0299240598771042 1.1739280899740918 1.1660432182358433 1.1383433970484502 1.145279657870573 1.20044151691653 1.0 15.393630584996918 -5.028932037393289 24.066107478581866 1.1375453601342855 1.0726795308523895 0.10697793265860389 0.0643972850604626 711.1777729071016 591572.0632373802 0.015266511001490846 0.04059476414552746 9.355520669411173e-06 5.028932037393289 -0.06486582928189599 KAGTQIENIDEDFRDGLK ddPTM_A459_Selumetinib_30min_R1 1 KAGTQIENIDEDFRDGLK 18 2 O43707;F5GXS2;O43707-3;K7EP19 O43707 ACTN4 Alpha-actinin-4 0 116.87 0.00065416 18509000.0 4525.5 3914.0 6394.2 5234.1 5199.2 4242.5 3854.1 4329.6 2995.2 3489.8 False True 4630.935344909889 3455.747060430765 5525.902760826458 4320.062691225498 4728.933277993313 4199.824301881798 3563.38213404629 4214.7649434771665 5082.6356392473435 3937.7498235306157 1.176035947544722 0.8775943661480039 1.4033148393038064 1.097089171437534 1.2009227325044525 1.0665543749846975 0.9049285235828759 1.0703485829117954 1.2907462045646705 1.0 11.94315574028528 -6.851848074524433 8.904672781173941 1.0602917719886664 1.146717787627422 0.07230644087067095 0.15017649387224846 0.8601394320204995 76.29084844334233 0.053141958994849886 0.04689239836350416 1.406539475594823e-07 6.851848074524433 0.08642601563875552 KAKMKIEES(ph)S(ph)GVEGVEHEES(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 KAKMKIEESSGVEGVEHEESQK 22 3 H9KVD6;Q6ZMT4-2;Q6ZMT4 H9KVD6 KDM7A Lysine-specific demethylase 7A 3 KAKMKIEES(1)S(1)GVEGVEHEES(1)QK 54.292 0.007202600000000002 19062000.0 2435.6 2713.4 763.78 1177.9 5864.3 1486.2 5134.1 2753.8 239.28 538.38 True False 2492.344741147391 2395.713866574564 660.0628711432294 972.201876921441 5333.875100426254 1471.2501773616318 4746.830703512377 2680.760278396948 406.0406836802571 607.4863172652916 4.102717493897026 3.943650743212289 1.0865477170162787 1.6003683528181865 8.780239075075217 2.4218655392679915 7.813889084582325 4.412873512056815 0.6683947804917185 1.0 9.24670810427781 -5.009276608200117 23.33021484354459 3.7470661017803675 4.062953632482059 0.0 2.6978542424561036 3291.414869008006 8278173.556192922 0.6848713381092767 2.1840226833329335 9.788663332317238e-06 5.009276608200117 0.3158875307016915 KAKPAMPQDSVPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 KAKPAMPQDSVPSPR 15 2 P53396 P53396 ACLY ATP-citrate synthase 1 KAKPAMPQDS(0.166)VPS(0.834)PR 81.96700000000001 0.010285 25690000.0 3168.3 3761.9 5867.0 7105.8 5288.0 4703.8 4032.8 3972.7 2367.9 3174.4 True False 3242.115225561374 3321.4549991401364 5070.293625124151 5864.905422385918 4809.70133367223 4656.484042708683 3728.6026491740954 3867.33109085175 4018.153355426612 3581.8651612744547 0.9051472011324415 0.9272976088129284 1.4155456436333582 1.637388667165556 1.3427924048265687 1.300016564847983 1.0409667816326817 1.0796975644598872 1.1218047510188582 1.0 11.806495312990382 -7.26233886869608 24.939656253745415 1.067258730830022 1.2685267573917776 0.17463300420787398 0.20518471991520532 163.2753885820705 4526926.755941562 0.09428681548668602 0.06767243342639169 5.4658930703200894e-08 7.26233886869608 0.20126802656175546 KAKPAMPQDSVPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 KAKPAMPQDSVPSPR 15 2 P53396 P53396 ACLY ATP-citrate synthase 1 KAKPAMPQDS(0.005)VPS(0.995)PR 60.618 0.032438 14174000.0 93695.0 105630.0 102800.0 122530.0 108940.0 61878.0 53729.0 66000.0 40814.0 85338.0 True False 88487.80699080258 113731.48134601733 96185.95992017702 105841.20262396031 95253.98326404319 70401.13282744244 56227.504961993756 66192.04907311178 48977.94043844151 82874.07020524808 1.0677381570815982 1.3723409633959933 1.1606279223641407 1.2771329121621666 1.1493822256845199 0.8494952963343682 0.6784692102456082 0.7987063855941771 0.5909923371344193 1.0 16.338633158737842 -6.779188209652901 2.9565017239718294 0.7504898491027644 1.225969040033361 0.7516784334111278 0.12223359711708434 0.11325034241902197 2.0352831141790992 0.04197465351115956 0.038606780008119845 1.6626919355028308e-07 6.779188209652901 0.47547919093059654 KALDSNS(ph)LENDDLSAPGREPGHFNPESR ddPTM_A459_Selumetinib_30min_R2 1 KALDSNSLENDDLSAPGREPGHFNPESR 28 2 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 KALDS(0.267)NS(0.717)LENDDLS(0.017)APGREPGHFNPESR 41.214 0.032792 6576600.0 9585.7 8811.6 8158.7 10253.0 11438.0 5607.0 5375.6 4810.1 4510.9 7614.6 True False 9052.965168597433 9487.421386240334 7633.778124520909 8856.523712588461 10001.05618298261 6379.31335472171 5625.576051549318 4824.096594645078 5413.206045076837 7394.746712893219 1.2242427658560642 1.2829947738031922 1.0323244893852717 1.1976777645604195 1.3524541909657462 0.8626817932247719 0.760753041309821 0.6523680637004041 0.7320340040367525 1.0 12.85228501720469 -6.888787807592227 5.210590177313275 0.7646016262091498 1.2087155477277045 0.7718023599429868 0.1132980092944331 0.09639751160746522 4.033308761525632 0.04074653053761787 0.03589068731439657 1.2918503059723068e-07 6.888787807592227 0.44411392151855467 KALVVPEPEPDS(ph)DSNQER ddPTM_A459_Selumetinib_30min_R1 3 KALVVPEPEPDSDSNQER 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 KALVVPEPEPDS(0.565)DS(0.435)NQER;KALVVPEPEPDS(0.5)DS(0.5)NQER;KALVVPEPEPDS(0.978)DS(0.022)NQER 198.45 1.095e-10 46066000.0 10162.5 11006.3 15477.3 16418.0 13972.8 12243.2 12671.5 10937.4 7088.389999999999 9139.6 True False 10399.266477217263 9717.67727930994 13375.567670723365 13550.904504029391 12708.962707098202 12120.044523936172 11715.67855311682 10647.304622317799 12028.480114478 10312.756687242949 1.0083886193185696 0.9422967664243324 1.2969924605386225 1.3139943969387047 1.23235358813608 1.1752477917886754 1.1360375221117462 1.0324402044206755 1.1663690397502957 1.0 13.332142408416143 -7.572058528423205 5.651707790848209 1.0749951364870876 1.1670566902074235 0.11671747027205681 0.1158935037632629 0.5060614469360093 36.51488579029606 0.06183908963519337 0.03542708298930156 2.6788072865412088e-08 7.572058528423205 0.09206155372033598 KALVVPEPEPDS(ph)DSNQER ddPTM_A459_Selumetinib_30min_R2 1 KALVVPEPEPDSDSNQER 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 KALVVPEPEPDS(0.579)DS(0.421)NQER 64.257 0.018308 35917000.0 72268.0 104820.0 110660.0 118170.0 100870.0 74145.0 64946.0 66948.0 50317.0 98161.0 True False 68251.63387172556 112859.35695057765 103540.2560774981 102075.04214537982 88197.80881075854 84357.80072870359 67966.11768805764 67142.80759616203 60381.80597444657 95326.8368770928 0.7159750192878427 1.1839200863875297 1.086160618242217 1.070790193919763 0.9252148891132735 0.8849323390166416 0.7129798901823208 0.7043431817918272 0.6334187512410413 1.0 16.540594805426778 -6.864505567934479 1.838533201632098 0.7389878885076246 1.0273606872042371 0.35654033817157693 0.1463387199179581 0.3259682012650927 2.2625735071880397 0.06127369844088873 0.05196719729848269 1.3661375608162726e-07 6.864505567934479 0.2883727986966125 KALVVPEPEPDSDS(ph)NQER ddPTM_A459_Selumetinib_30min_R1 3 KALVVPEPEPDSDSNQER 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 KALVVPEPEPDS(0.172)DS(0.828)NQER;KALVVPEPEPDS(0.084)DS(0.916)NQER;KALVVPEPEPDS(0.067)DS(0.933)NQER 196.1 1.4109e-10 39900300.0 8370.4 9888.3 12738.2 14727.3 13150.0 10219.3 10703.2 9372.8 5056.7 7102.199999999999 True False 8565.414034036843 8730.573239054045 11008.422405924057 12155.453520659767 11960.584821821067 10116.503120381996 9895.849006804248 9124.202896854858 8580.850573244545 8013.836551286366 1.0688281423286503 1.0894373978282137 1.373676931825744 1.516808265662543 1.4924917354224272 1.2623795176803443 1.2348453756791167 1.138556150785264 1.0707543781719835 1.0 12.96827736979225 -7.890506259622872 1.4516782271917912 1.0217031258364173 1.3114977680483437 0.3755854288659898 0.13799294754390887 0.5214541282594318 1.994428564118545 0.13675470412537116 0.04869656104203872 1.2867487065824653e-08 7.890506259622872 0.2897946422119264 KALVVPEPEPDSDS(ph)NQER ddPTM_A459_Selumetinib_30min_R2 3 KALVVPEPEPDSDSNQER 18 1 C9J0A5;C9JXC9;Q5VTR2 C9J0A5 RNF20 E3 ubiquitin-protein ligase BRE1A 1 KALVVPEPEPDS(0.028)DS(0.972)NQER;KALVVPEPEPDS(0.001)DS(0.999)NQER;KALVVPEPEPDS(0.295)DS(0.705)NQER 203.53 4.1223e-11 71235000.0 179452.0 212827.0 235218.0 254322.0 222898.0 157476.0 140920.0 147765.0 122688.0 194994.0 True False 169478.7762432735 229150.14655333577 220084.3299659942 219682.9048700796 194895.56050659696 179166.88957520155 147473.05922768248 148194.97168618732 147229.02818913915 189364.01656474403 0.8949893402019611 1.2101039611978697 1.162228885712016 1.1601090262836153 1.0292111671594253 0.9461506617015801 0.7787807942765149 0.7825930943723888 0.7774921067899992 1.0 17.53080268668124 -6.84232028979726 2.053356281785738 0.8178647634137023 1.1155895516330216 0.5872876627481236 0.10155965398789431 0.20280170081445661 1.7542512576813605 0.04078206605168227 0.03547089575384418 1.4377378633834082e-07 6.84232028979726 0.29772478821931936 KANDES(ph)NEHSDVIDSQELSK ddPTM_A459_Selumetinib_30min_R1 1 KANDESNEHSDVIDSQELSK 20 1 P10451-3;P10451-4;P10451-5;P10451-2;P10451;D6R9C5 P10451-3 SPP1 Osteopontin 1 KANDES(0.992)NEHS(0.008)DVIDSQELSK 59.628 0.016349000000000002 6540300.0 1189.6 1716.5 1389.1 1485.7 1422.0 1401.7 1355.6 1658.1 780.5 1186.9 True False 1217.3153654413436 1515.5313820207987 1200.4678497801183 1226.2503850430294 1293.3803510744915 1387.6001706417712 1253.346000600179 1614.1218017321446 1324.451494535441 1339.2501763850341 0.9089529252310254 1.1316267929204915 0.8963731130657578 0.9156245835658435 0.965749621602174 1.0361022870179832 0.9358565133687481 1.2052429263732163 0.9889500243415772 1.0 10.387209770728822 KANNSQEPS(ph)PQLASSVASTR ddPTM_A459_Selumetinib_30min_R1 1 KANNSQEPSPQLASSVASTR 20 1 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 KANNSQEPS(0.997)PQLAS(0.001)S(0.001)VASTR 93.229 0.00065955 10516000.0 2397.7 2448.2 3486.6 3805.0 2941.5 2641.5 3021.6 3080.8 1634.8 2755.6 True False 2453.5617448879543 2161.5636058626983 3013.138870522901 3140.5281786960536 2675.441844364006 2614.928908290103 2793.6782792958847 2999.0871761512503 2774.136198932147 3109.3081018170005 0.7891021618134771 0.6951911920853181 0.9690705365486615 1.0100408437686856 0.8604621210746358 0.841000255575189 0.8984887273356186 0.9645513014289772 0.8922037019461058 1.0 11.602377865297356 -5.261866885757924 24.99977132332603 0.9243569916780577 0.742146668682792 0.623197632966055 0.05815669933219257 24.288407044551803 1420450.130918008 0.015785205696549617 0.03646677336263705 5.4718365274204e-06 5.261866885757924 -0.18221032299526574 KANNSQEPS(ph)PQLASSVASTR ddPTM_A459_Selumetinib_30min_R2 5 KANNSQEPSPQLASSVASTR 20 1 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 KANNSQEPS(0.997)PQLAS(0.001)S(0.002)VASTR;KANNSQEPS(1)PQLASSVASTR;KANNSQEPS(1)PQLASSVASTR;KANNSQEPS(0.994)PQLAS(0.002)S(0.002)VAS(0.001)TR;KANNSQEPS(0.998)PQLAS(0.001)S(0.001)VASTR 118.04 0.00013362 39954900.0 125373.0 119987.0 122925.0 139643.0 124662.0 95012.0 103171.0 104264.0 85874.8 130009.0 True False 118405.27056788413 129189.617080986 115016.13933062028 120623.38250238892 109000.84506757978 108099.04056693752 107968.65592945818 104567.3909781655 103052.15954238935 126255.30236605134 0.937824141631631 1.0232411206495489 0.9109806651696464 0.9553926072163383 0.8633367710098558 0.8561940650502466 0.8551613588190159 0.8282217777673511 0.816220448655778 1.0 16.945984452689935 -6.134806746929769 1.6116955319653183 0.8573822705064668 0.969327836446322 0.3552745940207429 0.055068318529972314 0.35306927866160615 1.8281142760328235 0.01828894700067988 0.027489270586401923 7.331506991640962e-07 6.134806746929769 0.11194556593985527 KAPAGPSLEETSVSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 KAPAGPSLEETSVSSPK 17 1 A0A087WXZ7;K7EIX2;Q6AI08 A0A087WXZ7 HEATR6 HEAT repeat-containing protein 6 1 KAPAGPSLEETSVS(0.003)S(0.997)PK;KAPAGPSLEETSVS(0.006)S(0.993)PK 171.33 3.7144e-07 121321000.0 17228.1 21435.9 21976.1 20699.1 15315.9 18484.1 16842.2 16073.9 11288.599999999999 18792.4 True False 17629.48120995294 18926.174862720447 18991.86632607651 17084.3907552293 13930.579549241766 18298.16673621998 15571.779294266984 15647.567956614379 19155.92971327711 21204.587593477212 0.8313993909212355 0.8925509529146592 0.8956489364555544 0.8056931397470171 0.6569606453240798 0.8629343369945435 0.7343589789530758 0.7379331424218672 0.903386101183581 1.0 14.372088803882946 -5.8217063782431815 6.90480754537847 0.795233130494924 0.8749740626757173 0.05113100986985075 0.09328389339384188 0.42104226576951537 38.496362109784755 0.02516509096014283 0.03781725897603497 1.5076260111823662e-06 5.8217063782431815 0.07974093218079337 KAPAGPSLEETSVSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 KAPAGPSLEETSVSSPK 17 1 A0A087WXZ7;K7EIX2;Q6AI08 A0A087WXZ7 HEATR6 HEAT repeat-containing protein 6 1 KAPAGPSLEETSVS(0.001)S(0.999)PK;KAPAGPSLEET(0.004)S(0.024)VS(0.361)S(0.61)PK;KAPAGPSLEETSVS(0.052)S(0.948)PK 249.26 9.195299999999996e-31 74058000.0 620670.0 555975.0 568434.0 500908.0 516138.0 448093.0 536286.0 497472.0 345907.0 511229.0 True False 586175.6461388707 598616.494758611 531861.575304143 432683.4662855034 451296.13010773575 509813.74336674024 561224.3616305494 498919.56115907675 415098.06544910977 496468.49043753976 1.180690532086481 1.2057492193130883 1.0712896901783457 0.871522512746333 0.9090126338330285 1.0268803623719187 1.130432993110882 1.0049370116507834 0.8361015320091757 1.0 18.921342630998026 -5.468695789227513 4.136822116670344 0.9746813948309759 1.188570942185117 0.557224836710129 0.07981436536118092 0.17788290749773245 6.2046837184309895 0.0235273861402558 0.04995862946171445 3.3986325364891224e-06 5.468695789227513 0.213889547354141 KAPAGQEEPGT(ph)PPS(ph)SPLSAEQLDR ddPTM_A459_Selumetinib_30min_R1 3 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 2 KAPAGQEEPGT(1)PPS(0.607)S(0.308)PLS(0.084)AEQLDR;KAPAGQEEPGT(1)PPS(0.96)S(0.038)PLS(0.002)AEQLDR;KAPAGQEEPGT(1)PPS(0.997)S(0.003)PLSAEQLDR 152.09 9.8745e-10 28742600.0 3730.26 3809.13 4576.9 5198.9 4381.0 4036.2999999999997 4204.1 4284.4 2163.49 3082.44 True False 3817.1678001775645 3363.1552887835046 3955.3821191121083 4291.009710439665 3984.7393235283735 3995.6984866671737 3886.981352259671 4170.763794307457 3671.2845149423233 3478.1011995081994 1.0974861228066937 0.966951533572126 1.137224563699123 1.2337219259308527 1.145665147434989 1.1488160514800898 1.1175584404528789 1.199149637997077 1.0555427528852352 1.0 11.764084194852469 -5.323754443004264 10.641783152152051 1.1414184012663329 1.0322936236995035 0.225725849369379 0.06957356663568433 0.7728732225762392 130.16679449293215 0.017113509647470736 0.035673991355472195 4.745102050293725e-06 5.323754443004264 -0.10912477756682937 KAPAGQEEPGT(ph)PPS(ph)SPLSAEQLDR ddPTM_A459_Selumetinib_30min_R2 2 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 2 KAPAGQEEPGT(1)PPS(0.851)S(0.148)PLS(0.001)AEQLDR;KAPAGQEEPGT(1)PPS(0.556)S(0.433)PLS(0.011)AEQLDR 130.62 1.6807000000000002e-07 44065000.0 74019.0 71943.0 80206.0 92787.0 90978.0 59159.0 65185.0 64809.0 54433.0 66533.0 True False 69905.3203015338 77460.79676679487 75045.63328168986 80149.25053349702 79548.53028636058 67307.61525806703 68216.23166162707 64997.58346029249 65321.12098509552 64612.01941650573 1.0819243994047931 1.1988604824044053 1.1614810055374738 1.2404696720100061 1.2311723268324155 1.0417197274733792 1.055782380394082 1.005967373365957 1.0109747625131282 1.0 15.97951494601079 -6.827142750667385 6.4846744934655565 1.023695580111391 1.1854910507997023 0.7723762919744946 0.04342834560869426 0.10327511637841345 7.878854441434248 0.015937160920189746 0.01412513363819821 1.4888716117863613e-07 6.827142750667385 0.16179547068831135 KAPAGQEEPGT(ph)PPSS(ph)PLSAEQLDR ddPTM_A459_Selumetinib_30min_R1 1 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 2 KAPAGQEEPGT(1)PPS(0.293)S(0.621)PLS(0.086)AEQLDR 101.98 5.3477e-06 21365000.0 867.55 963.5 1252.6 1157.8 1037.9 823.23 1063.3 803.19 515.63 1041.9 True False 887.762227041558 850.6929720810024 1082.5038000392892 955.611964597711 944.0221282561276 814.9490536330354 983.0944249322582 781.8867920711905 874.9864498748364 1175.6380139654273 0.7551322911438836 0.723601110184941 0.9207798550065625 0.8128454109564147 0.8029870734376314 0.6931972630624729 0.8362220456076276 0.6650744385458294 0.7442651900337136 1.0 10.199228198706754 -11.164618841954486 6.465167378576073 1.0010910395048451 0.7740300361981973 0.4821182708741948 0.07066817216028541 0.0011482218392729604 6.36272719491445e-05 0.07069510361598204 0.01706819704735145 6.845121450155261e-12 11.164618841954486 -0.2270610033066478 KAPAGQEEPGT(ph)PPSS(ph)PLSAEQLDR ddPTM_A459_Selumetinib_30min_R2 2 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 2 KAPAGQEEPGT(1)PPS(0.268)S(0.69)PLS(0.042)AEQLDR;KAPAGQEEPGT(1)PPS(0.243)S(0.705)PLS(0.051)AEQLDR 105.5 9.0896e-07 42584000.0 55540.0 48449.0 65081.0 71879.0 58712.0 49865.0 51120.3 50519.0 48431.7 57252.0 True False 52453.30914423581 52164.88251191134 60893.75931483514 62088.95620180891 51336.07366806043 56733.4511205989 53497.49524295276 50666.001926129335 58119.393294763286 55598.98600143969 0.9434220462739658 0.9382344223069207 1.0952314726253882 1.1167282115576922 0.9233275165617432 1.0204044210290064 0.9622027143007156 0.911275646732431 1.0453318931618345 1.0 15.762770951274595 -6.312507233770191 24.999708543684996 0.9740754991250504 1.0224517825622956 0.10790361499031342 0.06486854643252142 860.2532834920611 421124.87464042637 0.021355799332293632 0.024215233568847982 4.86959414121451e-07 6.312507233770191 0.048376283437245204 KAPAGQEEPGT(ph)PPSSPLSAEQLDR ddPTM_A459_Selumetinib_30min_R1 2 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 KAPAGQEEPGT(1)PPSSPLSAEQLDR;KAPAGQEEPGT(0.961)PPS(0.03)S(0.007)PLS(0.001)AEQLDR 146.6 2.3643e-09 325990000.0 7579.4 9063.0 9721.9 10344.8 8996.7 7153.6 8226.6 7250.2 4333.4 6458.1 True False 7755.985273054912 8001.899746725612 8401.71937857414 8538.274875946106 8182.950073496392 7081.641278949115 7606.060938726345 7057.901144031353 7353.463300986395 7287.060042221064 1.0643504003146544 1.0980971338733019 1.1529642036561747 1.1717036536649255 1.1229425894784126 0.9718104747207026 1.043776350772053 0.9685526265926219 1.0091124895884749 1.0 12.831121162588763 -6.752969242085716 24.891173864106232 0.9995052991078573 1.125163302908187 0.7730709395447567 0.033394844674640836 85.83765672143302 252250.51449682645 0.011744424697089372 0.011563485829550633 1.7661629007084808e-07 6.752969242085716 0.12565800380032954 KAPAGQEEPGT(ph)PPSSPLSAEQLDR ddPTM_A459_Selumetinib_30min_R2 3 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 KAPAGQEEPGT(0.996)PPS(0.002)S(0.002)PLSAEQLDR;KAPAGQEEPGT(0.996)PPS(0.003)S(0.001)PLSAEQLDR;KAPAGQEEPGT(0.954)PPS(0.025)S(0.021)PLSAEQLDR 100.57 6.6727e-06 245558000.0 142946.0 144594.0 160403.0 164207.0 171891.0 124141.0 131562.0 125743.0 113088.0 145147.0 True False 135001.63357817667 155683.89485701048 150082.84561358145 141841.72332712534 150296.51585496299 141240.29591020278 137679.89368515738 126108.89131212585 135708.75994272748 140956.22897280377 0.9577557129754373 1.104483966345668 1.0647478774601622 1.0062820519587852 1.0662637398164314 1.0020152847410086 0.9767563639328168 0.8946670340936648 0.9627723509041325 1.0 17.10488770764568 -7.1764490706063295 2.3345383939548507 0.9465809705900976 1.0426720528845819 0.41722530180861295 0.04465813133490321 0.2622554951131035 2.7968247980730077 0.01980977885963224 0.013871624868919808 6.661176318418822e-08 7.1764490706063295 0.09609108229448426 KAPAGQEEPGTPPS(ph)SPLSAEQLDR ddPTM_A459_Selumetinib_30min_R1 1 KAPAGQEEPGTPPSSPLSAEQLDR 24 1 P13051;Q68DM5;F5GYA2;P13051-2 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 KAPAGQEEPGTPPS(0.96)S(0.033)PLS(0.006)AEQLDR 170.55 2.9007e-16 10855000.0 1735.6 1749.6 1854.6 2505.2 2251.0 1906.3 1808.6 1681.1 1080.0 1491.7 True False 1776.0361031102873 1544.7560186330268 1602.755506588589 2067.7138484282136 2047.3974474463284 1887.124352781914 1672.1758458877862 1636.5117670176141 1832.6811199209194 1683.1742253884524 1.0551706866236046 0.9177635893732387 0.9522219877260157 1.2284609740569281 1.2163906840801453 1.1211699444520622 0.9934656915874956 0.9722771073445654 1.0888243725915914 1.0 10.716968802443814 KAPAPPVLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KAPAPPVLSPK 11 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 KAPAPPVLS(1)PK 75.316 0.027469 15559000.0 4017.2 4939.9 5825.5 5650.4 4082.9 4654.6 4359.1 4776.9 2787.7 4875.1 True False 4110.792943889514 4361.534211502797 5034.429097180967 4663.663711144335 3713.6024158945434 4607.778950038662 4030.289577468458 4650.201094441995 4730.523294447726 5500.866572495303 0.7472991554537518 0.7928812949782779 0.9152065462473576 0.8478052775289919 0.6750940723526727 0.8376460125533423 0.7326644855594521 0.8453579146408147 0.8599596503759344 1.0 12.425443194456111 -8.67492347749962 1.4997556166613344 0.9990697530017503 0.7975806692223655 0.4787310209424879 0.06423028993773584 0.5675323530409533 2.5749560084039116 0.06325914172332993 0.01848101107527536 2.1138614685037416e-09 8.67492347749962 -0.2014890837793848 KAPAPPVLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 KAPAPPVLSPK 11 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 KAPAPPVLS(1)PK;KAPAPPVLS(1)PK 97.797 0.0096943 73573000.0 602370.0 517140.0 573530.0 493100.0 517760.0 407640.0 553380.0 533580.0 379460.0 477810.0 True False 568892.6868781657 556802.9751328157 536629.7042122479 425938.92935505346 452714.35996687197 463788.7098125126 579113.266501668 535132.6294610762 455362.6029982607 464014.38380052947 1.2260238189571324 1.1999692133944153 1.1564936841331501 0.9179433746565842 0.9756472552831139 0.9995136487231959 1.2480502474048676 1.1532673299436318 0.9813544986872907 1.0 18.82381000202254 -5.537233355320292 24.463724929420987 1.0491632234636903 1.2043052860871704 0.38343759244569176 0.09109752013378285 207.95516364451584 354404.3669666468 0.02749210169731166 0.04764616975616779 2.9024626827522856e-06 5.537233355320292 0.15514206262348007 KAPAPVT(ph)PPAPVQNK ddPTM_A459_Selumetinib_30min_R2 2 KAPAPVTPPAPVQNK 15 1 Q03468;P0DP91 Q03468 ERCC6 DNA excision repair protein ERCC-6 1 KAPAPVT(1)PPAPVQNK;KAPAPVT(1)PPAPVQNK 111.58 0.0040191 10171700.0 120773.0 121937.0 135978.0 131758.0 132161.0 94716.0 89973.0 99058.0 89607.0 107608.0 True False 114060.92015262498 131289.17581074772 127229.32352165198 113812.33310477227 115557.75364566936 107762.2692537581 94156.92277811728 99346.24238006533 107530.90382877021 104501.0774408393 1.0914808052309102 1.2563427959398201 1.2174929353592523 1.0891020063329424 1.1058044230318058 1.0312072553966254 0.9010138946311046 0.9506719434190307 1.0289932550183147 1.0 16.673158291485002 -6.524337659843719 1.3086189278624705 0.9664620350913586 1.1872275236776677 0.7090821757624803 0.056412374063694176 0.22751477950455856 0.8083759175459034 0.024987248466534242 0.027949559341221855 2.98993908337691e-07 6.524337659843719 0.22076548858630907 KAPDFVFYAPR ddPTM_A459_Selumetinib_30min_R1 1 KAPDFVFYAPR 11 1 P15311;E7EQR4;P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P15311;P26038;A0A2R8Y5S7 EZR;MSN;RDX Ezrin;Moesin;Radixin 0 93.839 0.031165 7829100.0 3584.6 5432.4 4529.2 4517.8 4316.4 3774.4 4118.1 3997.6 2954.4 3616.4 False True 3668.114205582586 4796.372082545756 3914.15951711476 3728.851039609209 3925.9823821223154 3736.4329628810037 3807.4684014986715 3891.5706619651523 5013.401019161448 4080.6001667190462 0.8989153692389042 1.1754084905608915 0.9592117230789337 0.9137996586926925 0.9621090579131527 0.9156576999028146 0.9330657858988466 0.9536760532689287 1.2285940338017503 1.0 11.994565641239209 -8.231711510812804 24.585723546294822 1.1142970630834006 0.9664927817545088 0.3081488914836854 0.09003040618044607 594.2752988983864 491482.75740994286 0.060076984476434954 0.02269974637172787 5.865276483883046e-09 8.231711510812804 -0.14780428132889178 KAPEGES(ph)QPMTEVDLFIST(ph)QR ddPTM_A459_Selumetinib_30min_R2 1 KAPEGESQPMTEVDLFISTQR 21 1 A0A0G2JMD7;Q02410 A0A0G2JMD7 APBA1 Amyloid beta A4 precursor protein-binding family A member 1 2 KAPEGES(0.999)QPMT(0.009)EVDLFIS(0.203)T(0.79)QR 55.437 0.047318 2601400.0 13087.0 18486.0 11863.0 15032.0 13418.0 6649.0 7607.4 7188.4 3750.1 12859.0 True False 12359.67693141186 19903.816758141395 11099.747495457792 12984.615668353626 11732.31088155803 7564.839396387484 7961.159173777128 7209.317053896319 4500.224786548725 12487.72725830561 0.9897459061809198 1.5938702332646904 0.8888524921999181 1.0397901395321985 0.939507296954684 0.6057819201132933 0.637518662051347 0.5773121805732415 0.3603718029280002 1.0 13.608223312738087 -6.257940437699626 0.9704942959049682 0.5915875964152199 1.2501596361927125 0.5123604364503349 0.22714318932423186 0.40811903978345404 0.8139315372635821 0.1022187988314774 0.16185716819705567 5.521531603839448e-07 6.257940437699626 0.6585720397774927 KAPLNIPGT(ph)PVLEDFPQNDDEKER ddPTM_A459_Selumetinib_30min_R1 1 KAPLNIPGTPVLEDFPQNDDEKER 24 2 C9J470;E9PHA2;Q15003;C9JZP1 C9J470 NCAPH Condensin complex subunit 2 1 KAPLNIPGT(1)PVLEDFPQNDDEKER 84.573 0.00014953 24097000.0 5272.0 6003.6 7557.8 7650.9 5491.3 5434.7 5750.2 5756.9 3527.4 5523.3 True False 5394.827342473743 5300.695721002078 6531.492272023741 6314.813940180194 4994.612884567755 5380.031852312786 5316.457784487423 5604.208310953368 5985.740168897267 6232.269356497979 0.8656280776518283 0.8505241698957363 1.0480118715045237 1.013244707338612 0.8014115884385195 0.8632540643807989 0.8530532748788049 0.8992243419502122 0.960443110928177 1.0 12.605541872183329 -8.438131330136237 3.1015684185174477 0.9988393532997336 0.9004276614017672 0.178009819096561 0.07190087465581486 0.4585522750088789 8.734423757583691 0.07549803701170316 0.02019588550944686 3.646436624404595e-09 8.438131330136237 -0.09841169189796639 KAPPPPIS(ph)PTQLSDVSSPR ddPTM_A459_Selumetinib_30min_R1 2 KAPPPPISPTQLSDVSSPR 19 1 Q9P0K7;Q9P0K7-3;Q9P0K7-2 Q9P0K7 RAI14 Ankycorbin 1 KAPPPPIS(0.68)PT(0.318)QLS(0.002)DVSSPR;KAPPPPIS(0.69)PT(0.305)QLS(0.004)DVSSPR 201.85 7.676599999999998e-16 131049000.0 9426.3 10460.0 11196.3 12005.599999999999 12367.8 8867.3 8661.3 8272.3 4536.2 8507.8 True False 9645.9144496131 9235.338337277926 9675.903956873619 9909.047333023216 11249.134673712437 8778.103012864225 8007.971167747366 8052.891731782652 7697.6000890604355 9599.859002989791 1.00479751281857 0.9620285396276822 1.0079214657069593 1.0322075907507735 1.1718020723230407 0.914399160459582 0.834175915005976 0.8388552091519937 0.8018451194609302 1.0 13.22879750120617 -6.98727157058667 24.85155004252144 0.8580042014511464 1.0312315535225316 0.5590097522376234 0.07074130312286867 154.06097593928675 300794.22617825103 0.02513979804917294 0.02215742741269843 1.0297420065866684e-07 6.98727157058667 0.17322735207138518 KAPPPPIS(ph)PTQLSDVSSPR ddPTM_A459_Selumetinib_30min_R2 4 KAPPPPISPTQLSDVSSPR 19 1 Q9P0K7;Q9P0K7-3;Q9P0K7-2 Q9P0K7 RAI14 Ankycorbin 1 KAPPPPIS(0.894)PT(0.095)QLS(0.004)DVS(0.002)S(0.003)PR;KAPPPPIS(0.977)PT(0.022)QLS(0.001)DVSSPR;KAPPPPIS(0.994)PT(0.006)QLSDVSSPR;KAPPPPIS(0.958)PT(0.04)QLS(0.001)DVSSPR 151.85 1.011e-05 115373700.0 328742.0 269115.0 329417.0 320552.0 336873.0 189685.0 186945.0 196052.0 165045.0 216863.0 True False 310471.835698494 289755.25515888963 308222.6688621107 276892.26461695746 294552.002057169 215812.3869610106 195638.31292449008 196622.4788618443 198058.61174260266 210601.60171225845 1.474214028641086 1.3758454484822842 1.4635343053241843 1.314768085169983 1.3986218512222457 1.0247423818545862 0.9289497863923539 0.9336229034501191 0.9404420960349908 1.0 17.684156883134463 -6.807485756960872 3.728127126463877 0.9482727988680665 1.4057567128868005 0.9580060389352338 0.04621431607186762 0.0411597618959449 1.1821283626855312 0.0165473317417356 0.014993417282080805 1.5578091236052193e-07 6.807485756960872 0.457483914018734 KAPPPPISPTQLSDVS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 KAPPPPISPTQLSDVSSPR 19 1 Q9P0K7;Q9P0K7-3;Q9P0K7-2 Q9P0K7 RAI14 Ankycorbin 1 KAPPPPISPTQLS(0.005)DVS(0.497)S(0.497)PR;KAPPPPISPTQLSDVS(0.669)S(0.331)PR 187.18 1.2795e-15 16279600.0 116613.0 109502.0 122750.0 144064.0 136575.0 70196.0 92145.0 110501.0 101433.0 144236.0 True False 110132.11629882564 117900.45129557517 114852.39864009462 124442.23467573799 119417.22750400858 79864.86182415641 96429.92508185371 110822.53961557457 121722.43427481833 140071.53190986603 0.7862562420584793 0.8417160124402893 0.8199553262114706 0.8884191739675892 0.8525445954346513 0.570171973813696 0.6884334294559222 0.7911853187047833 0.8690019493264693 1.0 17.095804247152138 -8.565030670263972 2.5034614750215214 0.9990644481506479 0.7793294448785012 0.38424420072230325 0.08662105601584966 0.37283264442966413 5.6064808613487065 0.0933494263321517 0.025306539663792985 2.7225090352705136e-09 8.565030670263972 -0.21973500327214668 KAPS(ph)SPPPPPPPLR ddPTM_A459_Selumetinib_30min_R2 1 KAPSSPPPPPPPLR 14 1 Q13796 Q13796 SHROOM2 Protein Shroom2 1 KAPS(0.5)S(0.5)PPPPPPPLR 81.346 0.01648 12905000.0 27026.0 29806.0 29349.0 33159.0 34295.0 24741.0 27905.0 30597.0 30060.0 28176.0 True False 25524.003113649935 32092.024358604496 27460.71729277511 28642.686997534467 29986.55549881 28148.848173563383 29202.63779270851 30686.03220439396 36072.839946576 27362.48566996024 0.9328101043711583 1.1728475528755253 1.0035900109368614 1.0467867335963448 1.0959002723839006 1.0287387086497937 1.0672509122505807 1.1214636190045577 1.318331981300163 1.0 14.739911673400341 -7.886656450270701 3.9437179963784983 1.1757613075377846 1.0534879857122068 0.18554237671414664 0.09255366294800696 0.30709257358794506 8.706291705080547 0.051492907465276815 0.022891987257523436 1.298205813841367e-08 7.886656450270701 -0.12227332182557782 KAPSS(ph)PPPPPPPLR ddPTM_A459_Selumetinib_30min_R2 1 KAPSSPPPPPPPLR 14 1 Q13796 Q13796 SHROOM2 Protein Shroom2 1 KAPS(0.237)S(0.763)PPPPPPPLR 74.14699999999998 0.024104 11147000.0 33629.0 31374.0 35029.0 39652.0 34675.0 27456.0 28588.0 27283.0 25388.0 35565.0 True False 31760.03480755322 33780.28491668983 32775.27227669148 34251.32919648472 30318.816501566907 31237.81477924723 29917.39864604732 27362.389013056214 30466.309399989073 34538.146041032654 0.919563973405552 0.9780572725750115 0.9489586452542412 0.991695650246913 0.8778356680045009 0.9044438790123679 0.8662132185816892 0.7922367628114328 0.8821061027362013 1.0 15.07590302265966 -6.2767583636097255 23.537630737324125 0.8765700234068455 0.960131605715212 0.3114391286893895 0.05133391742066477 389.799802475267 598925.8231293169 0.015578274888680002 0.017740965338728355 5.287393543670121e-07 6.2767583636097255 0.08356158230836652 KAPWIPPNPT(ph)SPPASPK ddPTM_A459_Selumetinib_30min_R2 1 KAPWIPPNPTSPPASPK 17 1 Q2KHM9;Q2KHM9-2 Q2KHM9 KIAA0753 Uncharacterized protein KIAA0753 1 KAPWIPPNPT(0.769)S(0.228)PPAS(0.003)PK 85.988 0.014257 8100400.0 32895.0 32201.0 35705.0 39219.0 36492.0 29700.0 30096.0 29260.0 28313.0 33737.0 True False 31066.827589118442 34670.713157465696 33407.77917266465 33877.30454345138 31907.5487173808 33790.905410243395 31495.523634092646 29345.14175574623 33976.39113131755 32762.925150747065 0.9482311926110191 1.0582300877574458 1.0196824312527197 1.0340134279090432 0.9738919394580748 1.0313763271980887 0.9613159841246495 0.8956813721828834 1.0370377789830165 1.0 14.99977654947345 -7.2733285350693855 23.707489629801618 0.9648155565264286 1.012822459154511 0.13258321235484716 0.04453718686068813 598.7762844735136 1193978.8159409806 0.017740658013778776 0.01208171088102182 5.329315908959454e-08 7.2733285350693855 0.04800690262808238 KAPWIPPNPTS(ph)PPASPK ddPTM_A459_Selumetinib_30min_R2 1 KAPWIPPNPTSPPASPK 17 1 Q2KHM9;Q2KHM9-2 Q2KHM9 KIAA0753 Uncharacterized protein KIAA0753 1 KAPWIPPNPT(0.412)S(0.572)PPAS(0.017)PK 87.963 0.0053083 6031500.0 28293.0 29274.0 35564.0 34482.0 34548.0 28965.0 29176.0 29422.0 26992.0 30092.0 True False 26720.588325852783 31519.221669254086 33275.85095915546 29785.49211523217 30207.771376961315 32954.66583190909 30532.741811147236 29507.613148925695 32391.154219493666 29223.165771594384 0.9143632327413971 1.0785697181340812 1.138680566617474 1.0192424855004716 1.0336926400466848 1.127689795468423 1.0448129422318027 1.0097336263823888 1.1084067507490458 1.0 14.834824854596546 -4.758112199633131 24.997269025317898 1.064260556808032 0.9143630244585924 0.47022464338654557 0.04707131596138284 82.88149890722218 622592.225688663 0.011530145539079138 0.08098557465703243 1.7453711794160946e-05 4.758112199633131 -0.1498975323494397 KAQAVS(ph)EEEEEEEGK ddPTM_A459_Selumetinib_30min_R1 2 KAQAVSEEEEEEEGK 15 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 KAQAVS(1)EEEEEEEGK;KAQAVS(1)EEEEEEEGK 174.18 4.9008e-05 37835000.0 4066.2000000000003 8668.7 4717.1 5330.799999999999 4497.5 5838.0 6129.4 5069.8 2903.4 5914.4 True False 4160.9345485521135 7653.7645740307025 4076.543729175584 4399.875851509312 4090.7019190981164 5779.275020479891 5667.05442319175 4935.332434968711 4926.85774405407 6673.570851134583 0.623494474153175 1.1468769486023327 0.6108489473042045 0.6592985898638183 0.6129704786759925 0.8659944053036237 0.849178730488534 0.739533983389065 0.7382640948835433 1.0 12.704243200603004 -9.902481027269179 9.573421208830641 0.9999999916381535 0.7654142963670965 0.1746475861209812 0.15575136006316012 0.0 0.0 0.14981213247948372 0.036334779188937516 1.251753956370124e-10 9.902481027269179 -0.234585695271057 KAQAVS(ph)EEEEEEEGK ddPTM_A459_Selumetinib_30min_R2 4 KAQAVSEEEEEEEGK 15 1 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 KAQAVS(1)EEEEEEEGK;KAQAVS(1)EEEEEEEGK;KAQAVS(1)EEEEEEEGK;KAQAVS(1)EEEEEEEGK 202.34 1.0376e-28 13341100.0 84107.0 63670.6 67635.8 64441.2 63243.0 58628.6 75534.0 83833.0 59635.2 63699.0 True False 79432.6696469975 68553.93028675306 63284.18626429105 55664.19739272951 55297.84894040647 66704.15747255877 79046.48066778146 84076.94015069971 71563.90634670806 61859.844360121984 1.2840748383486695 1.1082137531362175 1.0230253069483517 0.8998437996170178 0.8939215659594237 1.078311110584683 1.2778318711506307 1.35915214498826 1.1568717491446165 1.0 15.916715583148585 -7.1383532522444835 5.1637698527106615 1.2272309923183098 1.0323909532930973 0.21906504695821383 0.135248960753464 0.3009002113015157 11.434250064093687 0.05523311508305566 0.04254054320047212 7.271880739694173e-08 7.1383532522444835 -0.19484003902521252 KAQAVS(ph)EEEEEEEGKSSSPK ddPTM_A459_Selumetinib_30min_R2 1 KAQAVSEEEEEEEGKSSSPK 20 2 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 KAQAVS(1)EEEEEEEGKSSSPK 94.856 0.0044419 0.0 9178.7 13645.0 10509.0 7214.8 7053.0 4585.8 5647.1 5982.8 2115.4 10311.0 True False 8668.584599247337 14691.527624409791 9832.862381334062 6232.131793775795 6166.939085379997 5217.452324252334 5909.701339516365 6000.208957494138 2538.539109214465 10013.294638804664 0.8657075330285245 1.4672021701504223 0.981980730221263 0.6223857400165101 0.6158751248046941 0.521052511930795 0.5901855036417699 0.5992242487543953 0.2535168694004896 1.0 13.289629116662587 -5.673990771066725 3.3328327431034297 0.5765890562152227 1.1788445374826233 0.5369647237852251 0.2179103637294828 0.1570120056998791 3.4383798176561933 0.057492635133010686 0.1054601218567903 2.1184061517571398e-06 5.673990771066725 0.6022554812674006 KAQAVSEEEEEEEGKSS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 KAQAVSEEEEEEEGKSSSPK 20 2 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 KAQAVS(0.145)EEEEEEEGKS(0.116)S(0.558)S(0.182)PK 80.596 0.0045621 6473800.0 385.89 801.49 855.08 1033.0 496.21 753.19 777.49 480.03 375.36 515.46 True False 394.88048618876974 707.6511781974074 738.964832618231 852.6059418115703 451.3278931129911 745.6135924418033 718.8433033392097 467.2980450428087 636.9585047902925 581.6243120055856 0.6789270634632232 1.2166808773127962 1.2705191605043058 1.465904922150817 0.7759783829474047 1.2819505255389718 1.2359237543913164 0.8034362309090014 1.0951373449192674 1.0 9.183943765216577 -7.747843974791185 24.95024348494344 0.9619650317329204 1.1457187614949949 0.09350411154397753 0.23425230526567947 496.5137847426082 911204.4817675969 0.11034856554171901 0.06326663484595611 1.787129506039882e-08 7.747843974791185 0.1837537297620745 KAQLDYVDLYLIHSPMS(ph)LKPGEELSPTDENGK ddPTM_A459_Selumetinib_30min_R1 1 KAQLDYVDLYLIHSPMSLKPGEELSPTDENGK 32 2 A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 A0A0A0MSS8 AKR1C3 Aldo-keto reductase family 1 member C3 1 KAQLDYVDLYLIHS(0.008)PMS(0.818)LKPGEELS(0.046)PT(0.127)DENGK 79.365 4.059e-06 10123000.0 2358.6 2912.8 1729.1 1992.5 2185.3 2224.2 2411.3 2472.6 1068.2 2045.2 True False 2413.5507909633106 2571.768021876017 1494.2977172664341 1644.5472788572633 1987.6400008460505 2201.8265674120194 2229.413699651234 2407.018615863276 1812.6573817588198 2307.7213419350146 1.0458588509388913 1.114418788413856 0.6475208640283544 0.7126281882362441 0.8612998305850146 0.9541128417028882 0.9660671152704597 1.0430282773417525 0.7854749829712604 1.0 11.17225331329045 -6.763989923060717 23.07647852903699 0.9534466036393454 0.8677637273170529 0.060104462717494145 0.1427370356436942 80.75063889113882 730589.1610846637 0.053573467035881256 0.04949401547156129 1.7219085279835865e-07 6.763989923060717 -0.08568287632229254 KAQLDYVDLYLIHSPMSLKPGEELS(ph)PTDENGK ddPTM_A459_Selumetinib_30min_R1 1 KAQLDYVDLYLIHSPMSLKPGEELSPTDENGK 32 2 A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 A0A0A0MSS8 AKR1C3 Aldo-keto reductase family 1 member C3 1 KAQLDYVDLYLIHSPMSLKPGEELS(0.719)PT(0.28)DENGK 91.335 4.8006e-08 9873200.0 2908.6 3408.5 2756.7 2586.2 2139.8 2728.9 2696.5 3297.0 1427.6 2495.8 True False 2976.3647208496077 3009.4312354313415 2382.3552814691925 2134.5687189865266 1946.2554678123734 2701.449743642956 2493.1008340353956 3209.5528498346785 2422.5329322213906 2816.160241150702 1.0568875582283788 1.0686292603156942 0.8459587088324726 0.7579713284050653 0.6911025300950632 0.9592670559609653 0.8852837269716931 1.139691130829698 0.8602255286551193 1.0 11.459513711157264 -10.401132772486717 11.792297323324084 1.0000974354417225 0.9159692452558063 0.03208192696919199 0.13400300840609713 0.0 0.0 0.1406915727517158 0.03412271853468211 3.970701386491233e-11 10.401132772486717 -0.08412819018591622 KAS(ph)DLEY(ph)K ddPTM_A459_Selumetinib_30min_R2 1 KASDLEYK 8 1 Q9NYH9 Q9NYH9 UTP6 U3 small nucleolar RNA-associated protein 6 homolog 2 KAS(1)DLEY(1)K 108.43 0.018126 0.0 138090.0 125180.0 136300.0 153740.0 155540.0 113960.0 139890.0 134360.0 108800.0 143400.0 True False 130415.51061806858 134780.90348285917 127530.60639221962 132800.34678370756 135999.67465475752 129656.9555741191 146395.16218677614 134750.96535550448 130563.04012599663 139259.66940205503 0.9364916000306408 0.9678387437050042 0.915775593463657 0.9536167029113157 0.9765905321957528 0.9310445452788485 1.0512387600470334 0.9676237631044956 0.9375509843345207 1.0 17.087417978045764 -6.707409455169376 1.533255369370803 0.9833566074494168 0.9443687750982853 0.209266436751955 0.03335298660979304 0.6522845558282159 3.1863582504044317 0.014586399001192562 0.013836573864386479 1.9615100825488685e-07 6.707409455169376 -0.03898783235113146 KAS(ph)GPPVSELITK ddPTM_A459_Selumetinib_30min_R1 2 KASGPPVSELITK 13 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 KAS(1)GPPVSELITK;KAS(1)GPPVSELITK 92.439 0.0094719 31764000.0 8121.5 12425.7 10176.4 11665.2 9285.1 9368.8 9600.3 8357.5 5060.9 7945.5 True False 8310.71514831193 10970.893267448788 8794.500774963932 9628.091802923838 8445.264344417546 9274.558378189782 8876.141641754131 8135.831951014052 8587.977666488685 8965.382320723973 0.926978331877856 1.2236949719465913 0.9809398484473953 1.0739187084825124 0.9419859680602638 1.0344855407617288 0.9900460821661161 0.907471835552136 0.9579042319965657 1.0 13.130149391509411 -6.2817570124705995 0.999695610114899 0.962257895976984 1.0691361775685564 0.1596961008701463 0.07993871656272093 0.8449032195825779 1.7855508200098749 0.035383765897242715 0.053893574706718 5.226885511669394e-07 6.2817570124705995 0.10687828159157242 KAS(ph)GPPVSELITK ddPTM_A459_Selumetinib_30min_R2 1 KASGPPVSELITK 13 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 KAS(0.999)GPPVS(0.001)ELITK 73.11 0.027126 7304200.0 82803.0 84061.0 79135.0 74129.0 63357.0 50078.0 61572.0 45833.0 47282.0 81536.0 True False 78201.14074667188 90508.2084012834 74043.54025567333 64032.502320342326 55397.527241233554 56975.78993717739 64435.22000260342 45966.366441938364 56739.72116946126 79181.84382403031 0.9876145460878899 1.1430424454679815 0.9351075534465189 0.8086765756888018 0.6996241128754995 0.7195562415014922 0.813762560844137 0.580516494969373 0.7165748917839894 1.0 16.272882041825433 -5.679953849755784 2.2963030684617296 0.736519432109445 1.0651939103306878 0.5619032939224908 0.10809583798174215 0.1895135320867769 2.024588917058858 0.030273605705409608 0.061305004132398165 2.089518161420827e-06 5.679953849755784 0.32867447822124274 KAS(ph)GSENEGDYNPGR ddPTM_A459_Selumetinib_30min_R1 1 KASGSENEGDYNPGR 15 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KAS(0.699)GS(0.3)ENEGDYNPGR 149.6 0.00050638 10629000.0 839.55 1142.4 1424.0 1536.0 1029.4 1088.5 1100.9 1015.5 632.21 920.45 True False 859.1098815200746 1008.6472769126484 1230.6286214720974 1267.7664342909695 936.290951755331 1077.5506782789244 1017.8582266603252 988.5656411911174 1072.814195208522 1038.5987234422478 0.8271817229590945 0.9711616759643891 1.1848932544355546 1.2206508689796833 0.9014944180290958 1.0375043353679247 0.980030307842877 0.9518263588026521 1.0329438800510684 1.0 10.020422641962737 KAS(ph)GSENEGDYNPGR ddPTM_A459_Selumetinib_30min_R2 1 KASGSENEGDYNPGR 15 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KAS(0.981)GS(0.019)ENEGDYNPGR 90.853 0.027183 7573700.0 5360.2 6692.0 7073.2 6212.9 7400.4 5219.5 4839.5 6460.1 5099.2 7721.5 True False 5062.301542580714 7205.254881828536 6618.118012717867 5366.692302149698 6470.695591584586 5938.43874709648 5064.546339287323 6478.897821472875 6119.182483552239 7498.560232133658 0.6751031379180207 0.9608851111113014 0.8825851640635194 0.7156963651704437 0.8629250671156372 0.7919438616560586 0.6754025016141324 0.8640189077509556 0.8160476536988585 1.0 12.872397900889247 -9.090252412918247 1.5593986285419423 0.9999387523697126 0.8062011107438706 0.3035754632955163 0.08884109529184621 5.231299857920052 13.052833599163955 0.084834082192913 0.024282232691889238 8.123582345201826e-10 9.090252412918247 -0.19373764162584206 KAS(ph)GSENEGDYNPGRK ddPTM_A459_Selumetinib_30min_R2 1 KASGSENEGDYNPGRK 16 2 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KAS(0.869)GS(0.131)ENEGDYNPGRK 82.859 0.021919 3281300.0 7790.1 9765.0 6652.4 7516.3 7206.5 4394.6 4947.1 5977.0 4449.5 9314.0 True False 7357.157428241115 10513.944100576155 6224.391826585472 6492.566973659285 6301.155043072581 4999.916259793123 5177.149952492678 5994.39208045438 5339.524329417496 9045.080619321758 0.8133877118270272 1.1623936306456646 0.6881521667467687 0.7178008960793684 0.6966389033185943 0.5527774124105087 0.572371896988231 0.6627240079706297 0.5903235752273348 1.0 13.142917646389462 -5.352399517112395 7.460725341749834 0.6646257242192729 0.9866127443169478 0.41295873908830083 0.142862268040093 0.20755020397716764 14.825260803593075 0.03510005600141467 0.073590492437428 4.442224293971694e-06 5.352399517112395 0.3219870200976749 KAS(ph)PEAASTPR ddPTM_A459_Selumetinib_30min_R1 3 KASPEAASTPR 11 1 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BVD2;H3BT57;H3BT29;P29590-10;P29590-14;H3BUJ5 P29590-2 PML Protein PML 1 KAS(0.992)PEAAS(0.006)T(0.002)PR;KAS(0.939)PEAAS(0.031)T(0.031)PR;KAS(0.999)PEAASTPR 140.82 0.0018935 15338100.0 5488.5 7093.799999999999 4229.4 4263.0 5622.3 5098.5 5508.6 5026.4 3079.42 5360.0 True False 5616.371371238079 6263.254598181851 3655.0707104312387 3518.5470764208353 5113.7639576976835 5047.213719067614 5093.081867000699 4893.083543951779 5225.55082806192 6048.008210821284 0.928631571827084 1.0355896321330123 0.604342881660027 0.5817695601215194 0.8455286070127978 0.8345249449293046 0.8421089538020136 0.8090404929009392 0.8640118607498254 1.0 12.562244382836004 -8.967406794856204 0.8059081619626899 1.001481625992324 0.8004741430410812 0.16851117076219513 0.12740994333522396 3.011882244204843 3.2985133162686027 0.14412814914526462 0.04808157168934064 1.077936567829716e-09 8.967406794856204 -0.20100748295124282 KAS(ph)PEAASTPRDPIDVDLPEEAER ddPTM_A459_Selumetinib_30min_R2 1 KASPEAASTPRDPIDVDLPEEAER 24 2 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;H3BVD2;H3BT29 P29590-2 PML Protein PML 1 KAS(0.997)PEAAS(0.002)T(0.001)PRDPIDVDLPEEAER 56.684 0.0052744 5054800.0 8442.3 7696.1 7381.5 11687.0 11343.0 5586.9 5858.0 8465.7 4698.1 9225.9 True False 7973.110763204574 8286.366123138165 6906.582326369533 10095.210438800492 9917.990932293393 6356.4447621713425 6130.408607406785 8490.333785427922 5637.851275881859 8959.524295233039 0.8899033587583114 0.9248667507433367 0.7708648471486612 1.1267574154770361 1.1069774025357921 0.7094623054433059 0.6842337165901209 0.9476322074315092 0.6292578813454981 1.0 13.129206419274507 -6.776633069476604 24.998714121210906 0.7839765148557735 0.9600332693477475 0.2592035696632664 0.14290464372984846 341.1778153833075 561348.3725238589 0.05070696566142707 0.044887453226166656 1.6725030965877143e-07 6.776633069476604 0.176056754491974 KAS(ph)PEPEGEAAGK ddPTM_A459_Selumetinib_30min_R1 6 KASPEPEGEAAGK 13 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK 152.34 0.00079248 571153000.0 29133.200000000004 32256.7 33912.9 35931.600000000006 27522.9 27804.3 29675.0 27583.6 15776.970000000001 23695.300000000003 True False 29811.94687666088 28480.070568267 29307.714450225467 29656.820579667576 25033.458554562654 27524.613986284523 27436.59085852043 26851.993323839786 26772.365785702517 26736.822566767434 1.1150145759547239 1.0652002681749604 1.0961554753575515 1.109212603913883 0.9362914569242055 1.0294646612382534 1.0261724552349303 1.0043075708336227 1.001329373333212 1.0 14.706540403711292 -6.239436803280785 24.999756492121623 1.0026320587797792 1.0941503310607132 0.7571004344372481 0.02681597603212689 415.7152950817963 472343.80330486613 0.00786094917468981 0.010140375039357956 5.761866567357137e-07 6.239436803280785 0.09151827228093401 KAS(ph)PEPEGEAAGK ddPTM_A459_Selumetinib_30min_R2 5 KASPEPEGEAAGK 13 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK;KAS(1)PEPEGEAAGK 99.915 0.0058293 591143200.0 278232.0 237592.0 259623.0 258060.0 241986.0 189342.0 216130.0 239409.0 176728.0 228766.0 True False 262768.97929094377 255814.5424213091 242919.13883614913 222911.78282166985 211585.5552977121 215422.14182445456 226180.4732534701 240105.6405537066 212078.53819289725 222160.93117454968 1.1827866308522479 1.1514830311019812 1.0934377055040785 1.0033797645839457 0.9523976793717676 0.9696670818110655 1.018092929560879 1.0807734703139946 0.9546167144315272 1.0 17.761245603690767 -5.523015839566138 2.170221908564482 0.9974487371497465 1.1714932171108818 0.7939080570526147 0.03535818403949634 0.14922493394958464 1.3822912264189968 0.011068341095019899 0.027429677482454746 2.99905313568033e-06 5.523015839566138 0.17404447996113537 KAS(ph)PEPPDSAEGALK ddPTM_A459_Selumetinib_30min_R1 7 KASPEPPDSAEGALK 15 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 KAS(0.996)PEPPDS(0.004)AEGALK;KAS(1)PEPPDSAEGALK;KAS(0.747)PEPPDS(0.253)AEGALK;KAS(0.998)PEPPDS(0.002)AEGALK;KAS(1)PEPPDSAEGALK;KAS(0.913)PEPPDS(0.087)AEGALK;KAS(1)PEPPDSAEGALK 149.74 0.00050176 608447000.0 53892.09999999999 58941.1 63946.0 66230.9 51980.4 55238.6 54211.0 53739.9 34199.0 47385.799999999996 True False 55147.68107422787 52040.248611026 55262.48443023502 54664.91662296989 47278.781997884966 54682.94983663588 50121.82062447349 52314.54328020336 58033.2052038662 53468.22900677891 1.0314102804346865 0.9732929176395226 1.0335574126315017 1.0223812839591013 0.8842406579782319 1.0227185536611465 0.9374131433849969 0.9784229672834446 1.0853773592633587 1.0 15.706394271631952 -8.235100723345834 24.531022153711735 1.0426886934004156 0.9841305157226419 0.1815620268288749 0.04856513847127499 837.8863369856026 780383.6549599852 0.03209167223838569 0.012122395834710083 5.819682296748483e-09 8.235100723345834 -0.058558177677773715 KAS(ph)PEPPDSAEGALK ddPTM_A459_Selumetinib_30min_R2 2 KASPEPPDSAEGALK 15 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 KAS(0.998)PEPPDS(0.002)AEGALK;KAS(0.999)PEPPDS(0.001)AEGALK 167.95 0.00012452 132677000.0 193304.0 169531.0 184055.0 187362.0 183383.0 127500.0 146748.0 172618.0 131112.0 161613.0 True False 182560.93753722272 182533.48257191794 172213.10168393195 161842.97238252198 160344.78807517912 145061.96767023674 153572.07277564568 173120.28980155187 157338.06357536506 156946.81276899818 1.1632025800098575 1.1630276483574054 1.0972704615378424 1.0311962984602319 1.0216504893997576 0.9242746960637288 0.9784975563771429 1.1030506879828046 1.0024928878736947 1.0 17.259916205815905 -5.602078595138867 1.7771120313292128 1.0052474100423465 1.1680161135926341 0.7006382006809175 0.04147054188275152 0.222511474159993 1.3918724049420337 0.013803020174996785 0.03489798618317127 2.4998929101495596e-06 5.602078595138867 0.1627687035502876 KAS(ph)QQSNQIQTQR ddPTM_A459_Selumetinib_30min_R2 1 KASQQSNQIQTQR 13 1 Q05D32;H0YMH7;Q05D32-2;H0YNU2;H0YNW9 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 KAS(0.996)QQS(0.004)NQIQTQR 63.462 0.042181 1199200.0 3368.8 2740.3 1992.6 3118.4 3541.0 2356.1 3261.3 2629.2 2972.1 3532.6 True False 3181.5755823748955 2950.4721985467327 1864.398285378843 2693.66854045995 3096.1479230583527 2680.6313884536876 3412.956912143353 2636.8505367125085 3566.603047412459 3430.604659202924 0.9274095672434933 0.8600443629177177 0.5434605472179421 0.7851876879004194 0.9025079339155682 0.7813874388768868 0.994855791088539 0.7686255918876883 1.0396426874325804 1.0 11.744247164836322 -7.7087439839738305 0.6716270156492183 1.0022743487476917 0.7813347545058059 0.28114546104190696 0.11892052156201277 0.9973427553681888 0.8893500433012536 0.11393891526948352 0.05968631466493199 1.9554918759571673e-08 7.7087439839738305 -0.2209395942418858 KAS(ph)SEGGTAAGAGLDSLHK ddPTM_A459_Selumetinib_30min_R2 1 KASSEGGTAAGAGLDSLHK 19 1 C9JEY1;C9K057;A0A1W2PNV4;O15143 C9JEY1 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 KAS(0.333)S(0.333)EGGT(0.333)AAGAGLDSLHK 70.117 0.011334 6071000.0 40931.0 27962.0 42326.0 46930.0 59043.0 33795.0 32967.0 54942.0 36533.0 28920.0 True False 38656.21887977524 30106.59548799903 39602.79124106439 40538.053041234416 51625.49048888289 38449.95448953453 34500.03082287121 55101.87212386225 43840.62081730741 28085.004456816103 1.3764006674527534 1.0719811540101891 1.410104502634429 1.4434056118298395 1.838187014293089 1.3690563784191567 1.2284146465391856 1.9619677187015465 1.560997466983399 1.0 14.777512411407614 -5.552173868211813 3.0797935985594656 1.5250987354162566 1.2239917989145348 0.1129581679235857 0.2709272897394255 0.4426710542952866 8.55997517660572 0.07450177200741 0.15392195356677216 2.804310717620638e-06 5.552173868211813 -0.3011069365017218 KAS(ph)SPNLHR ddPTM_A459_Selumetinib_30min_R2 1 KASSPNLHR 9 1 A0A087X030;P51956-2;P51956 A0A087X030 NEK3 Serine/threonine-protein kinase Nek3 1 KAS(0.619)S(0.381)PNLHR 71.555 0.035959 6103700.0 22234.0 15415.0 14574.0 15917.0 14500.0 14486.0 23229.0 49330.0 24931.0 37801.0 True False 20998.32328975405 16597.28093296277 13636.324706971413 13749.077141643475 12678.380368355303 16481.315009184713 24309.19452739027 49473.54213297889 29917.896630342162 36709.58691120697 0.5720119744344911 0.4521238817834758 0.371464945654521 0.37453641673766846 0.34536973676717553 0.448964872556307 0.6622028895664033 1.3477008676955513 0.8149886486793619 1.0 15.163869259595565 -7.556256133020673 4.90581760953343 1.0604730677961824 0.42796459824736005 0.8098281705442659 0.1356326054134773 0.074493937795393 4.425410443575463 0.06300267523030532 0.036324866446102805 2.7780743649494666e-08 7.556256133020673 -0.6325084695488223 KAS(ph)SPSPLTIGTPESQR ddPTM_A459_Selumetinib_30min_R1 1 KASSPSPLTIGTPESQR 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 KAS(0.493)S(0.493)PS(0.013)PLTIGTPESQR 226.22 6.4649e-16 10177000.0 1394.1 1253.0 2096.3 1936.8 1521.4 1337.2 1463.4 1353.4 812.15 1055.2 True False 1426.5798175536136 1106.298177496103 1811.6339741516547 1598.574238238769 1383.789638624986 1323.748982080457 1353.0145598099002 1317.5034355372309 1378.1592329109017 1190.6451985183983 1.1981569482905612 0.9291585594707358 1.5215565278438912 1.3426117538860316 1.1622183000837956 1.1117913075429093 1.1363709033501745 1.1065457931352607 1.1574894306262185 1.0 10.217527851855051 -6.494326899015301 7.50616318241808 1.1138203510830187 1.2458443165999775 0.18560034862739438 0.14261154359354997 0.44843943664108254 96.76760576298068 0.047387882174473483 0.05226520682100216 3.203856832616781e-07 6.494326899015301 0.13202396551695883 KAS(ph)SPSPLTIGTPESQR ddPTM_A459_Selumetinib_30min_R2 1 KASSPSPLTIGTPESQR 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 KAS(0.903)S(0.073)PS(0.024)PLTIGTPESQR 127.2 0.00057016 6759800.0 22589.0 19082.0 21695.0 22952.0 23508.0 14526.0 14809.0 13891.0 11056.0 19789.0 True False 21333.593810931634 20545.52804169936 20299.16731972999 19825.89800559157 20554.714875813548 16526.824646100875 15497.647843476796 13931.420510221158 13267.508930450571 19217.640152003234 1.1101047601158165 1.0690973438566393 1.0562778342799815 1.0316510169186892 1.0695753855954546 0.859982001712012 0.8064282461788802 0.7249287841810773 0.6903817963865649 1.0 14.230143569457912 -6.872321995495124 2.7097221011049983 0.7840337627687437 1.067813076582103 0.7123847103059155 0.0796699505483694 0.137777740085515 2.0501609664949205 0.029924264244113194 0.026010111156937694 1.341769774590682e-07 6.872321995495124 0.2837793138133593 KASGS(ph)ENEGDYNPGR ddPTM_A459_Selumetinib_30min_R1 3 KASGSENEGDYNPGR 15 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KAS(0.229)GS(0.741)ENEGDY(0.03)NPGR;KAS(0.044)GS(0.956)ENEGDYNPGR;KAS(0.001)GS(0.999)ENEGDYNPGR 154.81 0.00032493 34994000.0 2663.92 3523.72 3696.5 4605.8 3259.8300000000004 2692.33 3349.71 3129.53 1493.47 2296.83 True False 2725.984152914009 3111.161224267015 3194.535603421072 3801.4834915737965 2964.9789520697313 2665.2476046400516 3097.0386778330067 3046.5246982539034 2534.3095112669394 2591.6505035187765 1.0518332426431893 1.2004555475527583 1.2326259266377688 1.4668194983900749 1.1440504605247017 1.028397772393056 1.1950062995099249 1.175515253355932 0.977874720308937 1.0 11.339655461666736 -6.511062535744089 24.55509603768437 1.092963975435441 1.2436971287772203 0.3020264011757765 0.11483541693513848 632.158875752693 1313683.9217983983 0.03779641100929345 0.04057268648945128 3.0827440220401665e-07 6.511062535744089 0.15073315334177928 KASGS(ph)ENEGDYNPGR ddPTM_A459_Selumetinib_30min_R2 1 KASGSENEGDYNPGR 15 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KAS(0.001)GS(0.998)ENEGDYNPGR 186.17 3.9779e-05 6152400.0 15218.0 17501.0 16683.0 18192.0 19735.0 13302.0 12722.0 15340.0 8965.3 15606.0 True False 14372.244482480757 18843.270425415598 15609.633943077002 15714.218217049587 17255.7128668615 15134.22975646659 13313.598208164765 15384.636860326284 10758.610511411769 15155.41423074247 0.9483240948523157 1.2433358889783679 1.0299707883545113 1.0368715745936916 1.1385840468720818 0.998602184410578 0.8784714165818301 1.015124801347814 0.7098856123370176 1.0 13.887545664233281 -7.031652770236862 3.8894734898620373 0.903496394832067 1.0832639189277 0.3855717478178473 0.10589649863759784 0.230034830922461 7.514269122208972 0.0389588193981327 0.031172407203598183 9.297094166265957e-08 7.031652770236862 0.179767524095633 KASGS(ph)ENEGDYNPGRK ddPTM_A459_Selumetinib_30min_R1 1 KASGSENEGDYNPGRK 16 2 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KAS(0.493)GS(0.507)ENEGDYNPGRK 85.177 0.018662 7944200.0 855.1 1048.5 2133.7 2491.8 1725.4 1409.7 1116.9 933.64 707.89 649.25 True False 875.0221662650413 925.7411325655738 1843.9552595751502 2056.6539068790617 1569.337874644111 1395.5196979051896 1032.6513337786514 908.8768343098723 1201.237627760017 732.5875617305444 1.1944267306395877 1.263659364320567 2.517044181338943 2.8073830546900913 2.142184711595383 1.9049186347208016 1.4095944126314208 1.2406391833392463 1.6397188411476857 1.0 9.516857396169277 -7.244838850706475 3.406833060084422 1.328506877490003 2.020133586290824 0.3016446782136646 0.4847591692897779 0.3585842391870575 8.815335910384341 0.2350519405119257 0.16522714379528075 5.69064048556428e-08 7.244838850706475 0.6916267088008208 KASPEPPDS(ph)AEGALK ddPTM_A459_Selumetinib_30min_R2 1 KASPEPPDSAEGALK 15 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 KAS(0.034)PEPPDS(0.966)AEGALK 141.71 0.00069022 63029000.0 80110.0 88264.0 84754.0 87450.0 82058.0 63128.0 68621.0 69255.0 54328.0 80331.0 True False 75657.80690573879 95033.56498650843 79301.01991317801 75539.1591403356 71749.14043217241 71823.30898107224 71812.01246993199 69456.52058421748 65195.11805115037 78011.63530499635 0.9698272137219663 1.2181973190917315 1.0165281063925995 0.9683063153977699 0.9197235790745839 0.9206743160846448 0.9205295106194588 0.8903354007728261 0.835710183439455 1.0 16.251401695126113 -5.7556662304895445 2.1754530624869495 0.9111382998749112 1.0967008365397284 0.5065391765913286 0.06893373561789146 0.21909951531712268 2.115014062325413 0.019707204311618615 0.03787507605530094 1.7552289344489455e-06 5.7556662304895445 0.18556253666481715 KASS(ph)PNLHR ddPTM_A459_Selumetinib_30min_R2 1 KASSPNLHR 9 1 A0A087X030;P51956-2;P51956 A0A087X030 NEK3 Serine/threonine-protein kinase Nek3 1 KAS(0.19)S(0.81)PNLHR 67.51899999999999 0.042116 1705400.0 7487.0 6216.3 5076.6 6943.6 7046.2 7084.2 9968.8 17494.0 10191.0 11841.0 True False 7070.9025128356825 6693.07022144511 4749.977082984158 5997.869701621893 6160.993362172761 8059.984246035234 10432.368952802452 17544.904643712394 12229.484760331194 11499.119563387256 0.6149081652606829 0.5820506678403086 0.4130731102325345 0.5215938201667956 0.5357795723586631 0.7009218576783832 0.9072319750477857 1.525760693851265 1.0635148798060499 1.0 13.489235784183393 -7.344094237451088 2.3414868079240816 1.2194077161200902 0.5379381416751273 0.7850383998626506 0.14911994984286658 0.12357592065625335 1.323803558964664 0.07152245844549109 0.04406451117235906 4.527993164324153e-08 7.344094237451088 -0.6814695744449629 KASS(ph)PSPLTIGTPESQR ddPTM_A459_Selumetinib_30min_R2 1 KASSPSPLTIGTPESQR 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 KAS(0.191)S(0.661)PS(0.137)PLT(0.004)IGT(0.007)PESQR 70.538 0.016304 9094900.0 22540.0 23456.0 21267.0 26475.0 26111.0 11350.0 18342.0 16715.0 12204.0 20519.0 True False 21287.31703476909 25254.99977707262 19898.70437375884 22869.059328077612 22830.70274469829 12913.359474958337 19194.93934398349 16763.637882682797 14645.141008250608 19926.563155235464 1.0682884383489937 1.2674036952748258 0.9986019274242329 1.1476670186383366 1.145742121550941 0.6480475019379098 0.9632839940559569 0.8412709081886182 0.7349556917647775 1.0 14.282405281574494 -6.738455865326054 24.999765238591202 0.8354518181154045 1.1275991289974252 0.6162869850364803 0.11362490766087802 149.4043863399424 162510.66409533663 0.03557944092680903 0.035557141448475736 1.8261823233098836e-07 6.738455865326054 0.2921473108820207 KASSPS(ph)PLTIGTPESQR ddPTM_A459_Selumetinib_30min_R1 1 KASSPSPLTIGTPESQR 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 KAS(0.123)S(0.025)PS(0.57)PLT(0.265)IGT(0.017)PESQR 97.059 0.0029485 81962000.0 2579.0 2757.2 3753.3 4169.7 3321.6 3399.7 2791.4 2499.0 2042.4 2247.0 True False 2639.0856821395646 2434.3857422124943 3243.6224754011373 3441.5401699629288 3021.1618664761095 3365.5021046806214 2580.842450630968 2432.718402103992 3465.8036290060018 2535.424337633475 1.0408852052760706 0.9601492365907915 1.2793213456445258 1.3573823201425952 1.1915803684743416 1.3273920482367572 1.0179134168286346 0.9594916188170116 1.3669521024795905 1.0 11.308011506670777 -7.286809070939204 24.96703292258255 1.082713593600286 1.1935711575665087 0.10323132530677037 0.15392003958051134 1975.460300158157 1944097.7229351206 0.06774598659397685 0.04569141403196921 5.166434515242905e-08 7.286809070939204 0.1108575639662226 KASSPS(ph)PLTIGTPESQR ddPTM_A459_Selumetinib_30min_R2 2 KASSPSPLTIGTPESQR 17 1 Q9NPI6-2;Q9NPI6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 KAS(0.016)S(0.189)PS(0.688)PLT(0.1)IGT(0.006)PESQR;KAS(0.051)S(0.157)PS(0.777)PLT(0.015)IGTPESQR 120.08 0.0026587 25054000.0 98890.0 98046.0 107029.0 120093.0 116152.0 73995.0 62754.0 74219.0 56786.0 93933.0 True False 93394.08968803535 105565.81293242075 100142.87066436422 103736.12622801957 101559.94734794505 84187.13959026807 65672.18534469196 74434.96500238309 68144.78673340857 91220.9102227562 1.023823260039528 1.1572545447599145 1.0978060887555399 1.137196789362241 1.1133406485414532 0.9228930010091758 0.7199246881479725 0.8159857736632665 0.7470303307323172 1.0 16.477076945352493 -6.909782519901632 3.422683864735755 0.8058843424175764 1.1104982018566265 0.7510215981199634 0.07758499502967067 0.10507991747744452 2.4377433416985053 0.027325026524363992 0.023586032629658235 1.2308850023969572e-07 6.909782519901632 0.30461385943905006 KAST(ph)APGAEASPS(ph)PCITERSKQK ddPTM_A459_Selumetinib_30min_R1 1 KASTAPGAEASPSPCITERSKQK 23 3 Q66PJ3 Q66PJ3 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 2 KAS(0.326)T(0.365)APGAEAS(0.309)PS(0.98)PCIT(0.015)ERS(0.004)KQK 57.347 0.042382 23283000.0 915.89 659.08 1251.6 1254.0 1004.6 876.7 888.59 600.32 551.38 720.93 True False 937.2284549882925 581.9146072020209 1081.6395945466832 1035.0124404953624 913.7341073765356 867.8811939799107 821.5629408920867 584.3975634858217 935.651588798145 813.4683879528704 1.1521387540908254 0.7153499949351874 1.3296639556807825 1.2723450054402452 1.1232570569533602 1.0668898839006793 1.0099506668717473 0.7184023032001088 1.1502003060656776 1.0 9.667942472452161 -7.287016644326523 3.112918120403664 0.9398606602213703 1.1129426253964534 0.1254856343832449 0.18221825707038988 0.5232646694766059 10.348960376219242 0.08375437824896904 0.05623828228080536 5.163965780052623e-08 7.287016644326523 0.17308196517508312 KASTAPGAEASPS(ph)PCITER ddPTM_A459_Selumetinib_30min_R2 2 KASTAPGAEASPSPCITER 19 1 Q66PJ3 Q66PJ3 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 KASTAPGAEAS(0.145)PS(0.813)PCIT(0.042)ER;KASTAPGAEAS(0.039)PS(0.851)PCIT(0.11)ER 152.34 8.8937e-06 26630000.0 85738.0 110986.0 98934.0 104048.0 102570.0 77490.0 59026.0 57623.0 48220.0 100134.0 True False 80973.0251964079 119498.2693237628 92568.69415119468 89876.48290718859 89684.23961256568 88163.54411581693 61770.82595780009 57790.67338999883 57865.347379371065 97242.87124062338 0.8326885473799264 1.2288640575828882 0.95193295889153 0.9242475233458813 0.922270583626082 0.9066324656093294 0.6352221522228687 0.5942921332197015 0.5950600454421558 1.0 16.56930487126506 -7.119240031067761 3.1019373383757274 0.6719195478904718 0.9802305136336301 0.4180124007101824 0.14601740671378832 0.22486830549311854 4.106372634680283 0.058935601233728006 0.04445084988648221 7.599061668275287e-08 7.119240031067761 0.3083109657431583 KASVVDPSTESSPAPQEGSEQPAS(ph)PASPLSSR ddPTM_A459_Selumetinib_30min_R2 1 KASVVDPSTESSPAPQEGSEQPASPASPLSSR 32 1 Q66K14;Q66K14-2 Q66K14 TBC1D9B TBC1 domain family member 9B 1 KASVVDPSTESSPAPQEGS(0.127)EQPAS(0.809)PAS(0.036)PLS(0.007)S(0.021)R 93.406 2.412e-08 3898900.0 6923.6 7817.8 10333.0 9279.8 10668.0 6780.3 4877.3 7385.7 5219.7 11456.0 True False 6538.8140293667875 8417.40012181098 9668.18602971975 8015.875231452107 9327.790466869947 7714.224779564756 5104.104114186603 7407.191164231542 6263.785850603552 11125.235513737385 0.5877461219848059 0.7566042185279779 0.8690320324258775 0.7205128575978589 0.8384353261872108 0.6933987842360074 0.4587861630330504 0.6658008412572641 0.5630250112790026 1.0 13.44154825683339 -6.997969449286838 24.909965044208974 0.6343444191862123 0.759748759261023 0.04308939358533559 0.14827991451031863 124.31700263935149 1525045.2677372217 0.04979534903963971 0.04362409412945757 1.0046864630814472e-07 6.997969449286838 0.12540434007481072 KASVVDPSTESSPAPQEGSEQPASPAS(ph)PLSSR ddPTM_A459_Selumetinib_30min_R1 2 KASVVDPSTESSPAPQEGSEQPASPASPLSSR 32 1 Q66K14;Q66K14-2 Q66K14 TBC1D9B TBC1 domain family member 9B 1 KASVVDPSTESSPAPQEGS(0.001)EQPAS(0.005)PAS(0.794)PLS(0.1)S(0.1)R;KASVVDPSTESSPAPQEGSEQPAS(0.001)PAS(0.58)PLS(0.074)S(0.345)R 190.32 6.4981e-41 91875000.0 5123.9 6154.4 7925.799999999999 8028.1 7395.2 5667.8 6501.0 5285.3 3148.0 4765.1 True False 5243.276900626176 5433.8399868970655 6849.51989330305 6626.143041101132 6726.305465728602 5610.78707795065 6010.624336014873 5145.116674926058 5341.926079176901 5376.747001004565 0.9751764216628656 1.0106184996024237 1.2739152301611585 1.2323702491233335 1.250999064019916 1.0435281922140576 1.1178923492014552 0.956919987859717 0.9935237938811035 1.0 12.392517872886339 -7.540965859887341 1.7780299526806813 0.9798279255699152 1.1455398136279968 0.3042137105458861 0.09775913944447046 0.4823068937508888 2.983873742392393 0.06901821697520304 0.03364705255140007 2.877624617396259e-08 7.540965859887341 0.16571188805808168 KASVVDPSTESSPAPQEGSEQPASPAS(ph)PLSSR ddPTM_A459_Selumetinib_30min_R2 3 KASVVDPSTESSPAPQEGSEQPASPASPLSSR 32 1 Q66K14;Q66K14-2 Q66K14 TBC1D9B TBC1 domain family member 9B 1 KASVVDPSTESSPAPQEGSEQPAS(0.001)PAS(0.791)PLS(0.104)S(0.104)R;KASVVDPSTESSPAPQEGS(0.023)EQPAS(0.346)PAS(0.437)PLS(0.038)S(0.156)R;KASVVDPSTESSPAPQEGSEQPAS(0.045)PAS(0.722)PLS(0.092)S(0.14)R 176.96 1.3843e-34 136557000.0 171805.0 182384.0 204160.0 204326.0 208535.0 137970.0 119045.0 138037.0 99147.0 171417.0 True False 162256.76588990696 196372.26634300864 191024.56787260054 176496.4463179903 182336.96897344643 156974.11513303992 124580.82838319242 138438.66481674457 118979.17039864142 166467.74581514677 0.974703928952604 1.1796415298436802 1.1475169975853627 1.0602441058700935 1.095329116644143 0.9429701493486371 0.7483781784462471 0.8316245536866526 0.7147280682875421 1.0 17.34488314746745 -6.947853747146626 2.976129029903739 0.8103310911273027 1.0988085016209206 0.674916771927371 0.08729072316527195 0.1385158870397618 2.4994479046645544 0.03251771944111412 0.027208025829249867 1.1275771147082942e-07 6.947853747146626 0.28847741049361786 KAVPMAPAPAS(ph)PGSSNDSSAR ddPTM_A459_Selumetinib_30min_R1 2 KAVPMAPAPASPGSSNDSSAR 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 KAVPMAPAPAS(0.999)PGS(0.001)SNDSSAR;KAVPMAPAPAS(0.924)PGS(0.001)S(0.001)NDS(0.037)S(0.037)AR 211.11 1.2604000000000002e-17 41763000.0 5271.3 5433.4 9850.5 10932.8 8516.400000000001 6817.9 5907.8 5498.5 3541.3999999999996 4564.1 True False 5394.11103383571 4797.255002080867 8512.856204923375 9023.591714073122 7746.0931236925435 6749.318116157903 5462.169889602934 5352.661918354863 6009.497146377724 5149.946693098769 1.0474110423442122 0.9315154676279407 1.6529988973150154 1.752171867364232 1.5041113210109074 1.3105607724449626 1.06062649093486 1.0393625870977934 1.1669047282432656 1.0 12.330341783754045 -7.1743866753455725 3.908155174047226 1.0689425280461098 1.3899680046422285 0.28056509750201497 0.23609962588327854 0.3624584239741569 10.275428292424733 0.10903074350452556 0.08184620277757196 6.692884411603285e-08 7.1743866753455725 0.3210254765961187 KAVPMAPAPAS(ph)PGSSNDSSAR ddPTM_A459_Selumetinib_30min_R2 1 KAVPMAPAPASPGSSNDSSAR 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 KAVPMAPAPAS(0.967)PGS(0.011)S(0.003)NDS(0.009)S(0.009)AR 107.09 9.5796e-05 2327900.0 11393.0 14565.0 12400.0 14314.0 14122.0 8138.8 6490.8 8335.9 6195.8 13007.0 True False 10759.82266979256 15682.088666143543 11602.197500099193 12364.408506972724 12347.868107718175 9259.845823329595 6792.635061276195 8360.156088917467 7435.133125116287 12631.454113755433 0.8518277130164532 1.2415109555016333 0.9185163794772133 0.9788586805305415 0.9775492193152617 0.7330783724453216 0.5377555901405788 0.6618522312338848 0.5886205228754746 1.0 13.624733109090512 -6.794969324900326 3.6174866627375564 0.6648035755699857 1.006395948607524 0.48064965528633463 0.14913079610736754 0.1730455697492862 4.740262482638823 0.05119398339085757 0.04673815734106189 1.6033586351614373e-07 6.794969324900326 0.3415923730375383 KAVS(ph)PLLLTTTNSSEGLSMGNYIGLINR ddPTM_A459_Selumetinib_30min_R1 3 KAVSPLLLTTTNSSEGLSMGNYIGLINR 28 1 C9JZT2;P19525-2;P19525 C9JZT2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 KAVS(0.506)PLLLT(0.296)T(0.098)T(0.098)NS(0.002)S(0.001)EGLSMGNYIGLINR;KAVS(0.994)PLLLT(0.003)T(0.003)TNSSEGLSMGNYIGLINR;KAVS(1)PLLLTTTNSSEGLSMGNYIGLINR 128.65 1.6797e-12 56137000.0 12357.8 9502.5 19836.699999999997 18505.199999999997 14794.1 10391.5 9708.8 11620.2 7465.1 8920.0 True False 12645.71269590706 8389.942882407597 17142.9850951935 15273.614205625814 13455.976267110504 10286.970944727094 8976.457399400277 11311.99454827083 12667.729470668193 10064.968888157799 1.2564085231088695 0.8335786206233585 1.7032327954201156 1.5175023763457811 1.336911859006587 1.0220569044014134 0.8918514800340577 1.1238976169693133 1.2585959888631886 1.0 13.297055092298535 -6.757476291365793 24.476915528025323 1.0565596705476095 1.3331787406047755 0.26609239446480326 0.2243422413525096 118.46835562829246 731686.6491738855 0.0810472213781102 0.07815168814660761 1.7479286812464894e-07 6.757476291365793 0.276619070057166 KAVVLPGGTAT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 KAVVLPGGTATSPK 14 1 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 KAVVLPGGT(0.29)AT(0.542)S(0.168)PK 96.153 0.014972999999999997 33424000.0 15880.0 18261.0 19778.0 20948.0 12676.0 16039.0 14201.0 14125.0 10698.0 13227.0 True False 16249.973102898919 16122.993630691419 17092.256232777472 17289.82504266096 11529.458038129564 15877.662222246812 13129.807136709302 13750.359115533764 18153.72464899442 14924.814291890505 1.0887889648133475 1.080281021617264 1.1452240475825994 1.1584616534931023 0.7725026129399928 1.0638432017793376 0.8797300174008509 0.9213085567841947 1.216345094414901 1.0 13.865425359827773 KAVVLPGGTATS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KAVVLPGGTATSPK 14 1 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 KAVVLPGGTAT(0.033)S(0.967)PK 136.14 0.0010731 13489000.0 3897.9 4455.9 5816.6 6422.4 3300.1 3830.5 3838.7 4046.1 2501.8 3660.6 True False 3988.713486006906 3934.201156508291 5026.737668296768 5300.848403379118 3001.6065376799766 3791.9686478157264 3549.1437684448993 3938.7842844149495 4245.371875757551 4130.4736672635045 0.9656794371115028 0.9524818394774451 1.216988189063326 1.2833512159613896 0.7266978994369384 0.9180469247072958 0.859258296832638 0.9535914284195033 1.0278171991277136 1.0 12.012091518662293 -6.261242351455796 24.99999993331554 0.9093565997732337 1.1017837125823227 0.3709806489299482 0.12133001103808234 21.34163056642416 2707900.379347565 0.03927232477023984 0.04753704598060561 5.47971092618954e-07 6.261242351455796 0.19242711280908897 KAVVLPGGTATS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 KAVVLPGGTATSPK 14 1 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 KAVVLPGGTAT(0.244)S(0.756)PK;KAVVLPGGTAT(0.234)S(0.766)PK 163.0 0.00013935 58926000.0 623310.0 609460.0 544990.0 537270.0 514110.0 376240.0 476660.0 479930.0 307500.0 483320.0 True False 588668.9255076268 656203.6222772279 509925.93674024614 464092.89915755455 449522.90559828543 428063.6448333325 498825.63448387204 481326.51684331184 369008.592267868 469365.2957838302 1.2541807645249146 1.3980659161887579 1.0864159351378557 0.9887669653601661 0.9577250590024803 0.9120053158563314 1.062766333524603 1.0254838207403183 0.7861863575823844 1.0 18.84035164937952 -5.458096835579097 3.124916952927267 0.9658743615902519 1.3257721621593328 0.7679127519845949 0.0789038691430426 0.11266644903974181 2.1383713175050096 0.021455090004440014 0.04880220670427497 3.482596541705834e-06 5.458096835579097 0.35989780056908094 KAYGQALAK ddPTM_A459_Selumetinib_30min_R2 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 113.18 0.012538 8881100.0 100880.0 75656.0 92945.0 93593.0 91318.0 66933.0 61082.0 58285.0 69010.0 74355.0 False True 95273.49345463654 81458.57192761799 86965.01989086438 80845.47194306964 79845.81644672195 76152.41319272121 63922.43403168685 58454.59970039881 82813.92830050581 72208.1779525091 1.3194280226444346 1.1281072897476077 1.2043652444472532 1.1196165619390264 1.105772486036638 1.054623109903233 0.8852520011476853 0.8095288007245393 1.1468774126245376 1.0 16.13987461864798 -6.543661590680612 1.1697555381610032 0.9485692105006165 1.2081720692342097 0.5413025890282539 0.09574927854558836 0.35446576677107655 1.0225978743363675 0.04441459728256019 0.04946795283162697 2.8598180921324475e-07 6.543661590680612 0.25960285873359323 KAYS(ph)FCGTVEYMAPEVVNR ddPTM_A459_Selumetinib_30min_R1 2 KAYSFCGTVEYMAPEVVNR 19 1 B4DG22;B1AXG1;B7ZB17;P51812;E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q9UK32-2;Q9UK32 B4DG22;E9PGT3;Q9UK32-2 RPS6KA3;RPS6KA1;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6 1 KAYS(0.999)FCGTVEYMAPEVVNR;KAY(0.007)S(0.978)FCGT(0.015)VEYMAPEVVNR 136.77 8.7574e-05 395150000.0 5870.9 6499.6 8552.1 9459.3 7689.400000000001 7141.5 6971.1 6604.4 3518.5 4074.5 True False 6007.680547217206 5738.62381041794 7390.771793322692 7807.410828052454 6993.89512767383 7069.662993963194 6445.264314535194 6429.229857885396 5970.63751892755 4597.501763990914 1.3067271869847357 1.2482048088300162 1.607562579140165 1.6981854991775234 1.5212381607881538 1.537718386393025 1.4019057839230298 1.3984181383553032 1.2986699789201757 1.0 12.166634412839366 -8.658655087148608 1.005121775018545 1.0014937149504297 1.4877952908543766 0.5720559917993512 0.12543144434128223 0.5787721311075824 1.2243905788527463 0.13494069781699017 0.04423272668495028 2.194547133439101e-09 8.658655087148608 0.48630157590394685 KAYS(ph)FCGTVEYMAPEVVNR ddPTM_A459_Selumetinib_30min_R2 2 KAYSFCGTVEYMAPEVVNR 19 1 B4DG22;B1AXG1;B7ZB17;P51812;E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q9UK32-2;Q9UK32 B4DG22;E9PGT3;Q9UK32-2 RPS6KA3;RPS6KA1;RPS6KA6 Ribosomal protein S6 kinase alpha-3;Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6 1 KAY(0.021)S(0.979)FCGT(0.001)VEYMAPEVVNR;KAY(0.399)S(0.596)FCGT(0.004)VEYMAPEVVNR 71.418 0.007395100000000002 18672200.0 79904.0 83363.0 92974.0 90020.0 79055.0 57375.0 57188.0 47293.0 44831.0 81397.0 True False 75463.25556105535 89756.67404570694 86992.15406243737 77759.1207068382 69123.40413933297 65277.885451606555 59847.35531587217 47430.614800222356 53798.45268279934 79046.8571151958 0.9546648445627886 1.1354869418135576 1.1005137615485814 0.9837092016640084 0.8744611318144973 0.8258125349180729 0.757112395103274 0.6000316335297333 0.6805893952797933 1.0 16.270420482051378 -6.47875695218403 1.3164360442773861 0.731237300163491 1.0711750350740354 0.58709831323039 0.1074430606658997 0.27091508511678025 0.9688710035085939 0.044917383408410824 0.05231009951600159 3.3208025037883157e-07 6.47875695218403 0.33993773491054446 KCEDPDS(ph)PVTK ddPTM_A459_Selumetinib_30min_R2 1 KCEDPDSPVTK 11 1 Q9BUB4-2;Q9BUB4 Q9BUB4-2 ADAT1 tRNA-specific adenosine deaminase 1 1 KCEDPDS(0.936)PVT(0.064)K 83.823 0.019179 6634100.0 68924.0 56608.0 65783.0 64810.0 70272.0 55312.0 56961.0 58317.0 48963.0 64477.0 True False 65093.480004632904 60949.65157659136 61550.5933991149 55982.76619651403 61443.803120349134 62930.725927656036 59609.79936608022 58486.69281510093 58756.96814052565 62615.38147863523 1.0395765140685633 0.9733974326641732 0.9829947841189206 0.8940737064041637 0.9812892881809584 1.005036213811592 0.9519993004661237 0.9340627084585752 0.9383791450759412 1.0 15.934229478514702 -4.571670195757925 1.7441661786025004 0.9582081191284564 1.1064153079314172 0.34988991595428054 0.031903590898770665 1.982914314862117 3.8901643631059897 0.008938780256055037 0.5816472957670082 2.6812036642140636e-05 4.571670195757925 0.1482071888029608 KCFS(ph)NPFK ddPTM_A459_Selumetinib_30min_R1 1 KCFSNPFK 8 1 Q9Y620 Q9Y620 RAD54B DNA repair and recombination protein RAD54B 1 KCFS(1)NPFK 67.98100000000001 0.040039 85545000.0 2364.2 3422.6 3312.0 3492.8 4024.2 3245.2 3721.1 3375.0 2066.7 2827.6 True False 2419.281260067608 3021.880400876428 2862.2485915137513 2882.848047976235 3660.2118205302168 3212.5562344058476 3440.414431125205 3285.484036454969 3507.0389542042244 3190.5500031563915 0.7582646432979354 0.9471346312977075 0.8971019381241937 0.9035583348088108 1.1472040296842838 1.006897315894653 1.078313904411974 1.0297547548869819 1.099195734508073 1.0 11.639589429163088 -6.14210567174048 6.083963072387578 1.0595552017523413 0.8796928017008416 0.6899565117645692 0.06046947916966607 0.13545505982135705 6.238202754970315 0.017048714555392783 0.02216608786097105 7.209320419719295e-07 6.14210567174048 -0.17986240005149967 KCS(ph)LPAEEDSVLEK ddPTM_A459_Selumetinib_30min_R1 4 KCSLPAEEDSVLEK 14 1 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 KCS(1)LPAEEDSVLEK;KCS(1)LPAEEDSVLEK;KCS(0.873)LPAEEDS(0.127)VLEK;KCS(0.996)LPAEEDS(0.004)VLEK 182.49 0.00013652 252355000.0 18180.2 26072.7 25389.399999999998 25168.999999999996 19348.6 19463.600000000002 20618.4 18572.800000000003 11602.9 17219.6 True False 18603.763287488833 23020.0961631306 21941.65893399134 20773.70663064414 17598.52254627279 19267.813855534834 19063.137488030923 18080.189011043225 19689.273857713346 19429.903393107863 0.9574809977741795 1.1847766660176111 1.1292726726461462 1.0691616015966887 0.9057442124244068 0.9916577280754507 0.9811236372278085 0.9305341691743354 1.0133490352143226 1.0 14.245991107305919 -6.09486043804876 5.74425026027374 0.9689594742181981 1.099919231650062 0.457510085667718 0.061225239431436325 0.18548908194547065 9.042211299668882 0.017546119943780556 0.022951474600543968 8.037843794249683e-07 6.09486043804876 0.13095975743186383 KCS(ph)LPAEEDSVLEK ddPTM_A459_Selumetinib_30min_R2 6 KCSLPAEEDSVLEK 14 1 E7EVA0;P27816;P27816-6 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 KCS(0.995)LPAEEDS(0.005)VLEK;KCS(1)LPAEEDSVLEK;KCS(1)LPAEEDSVLEK;KCS(1)LPAEEDSVLEK;KCS(1)LPAEEDSVLEK;KCS(1)LPAEEDSVLEK 160.43 0.00052213 377903600.0 503835.0 523373.0 537389.0 584309.0 561492.0 450436.0 537684.0 516482.0 424386.0 580569.0 True False 475833.86771130795 563514.0261905638 502813.97680490266 504725.10621075303 490952.3551578312 512479.4703491047 562687.3714006335 517984.87711180217 509275.05833558255 563806.4644705841 0.8439666759729642 0.9994813144253413 0.8918201696694742 0.8952098601506661 0.8707817063056149 0.9089634522554197 0.9980151113183823 0.9187281625055355 0.9032799203779852 1.0 19.104840494037568 -7.0353782622576215 24.448473343992458 0.9489840371788504 0.9035017757228692 0.2326713718468152 0.046950269026865166 832.3752485297762 575217.5285831416 0.017726547490331854 0.013737120693884601 9.217682347711293e-08 7.0353782622576215 -0.04548226145598122 KDAPIS(ph)PASIASSSSTPSSK ddPTM_A459_Selumetinib_30min_R2 1 KDAPISPASIASSSSTPSSK 20 1 Q04727-4;Q04727;Q04727-3;H0Y5S0;H7C4E4 Q04727-4 TLE4 Transducin-like enhancer protein 4 1 KDAPIS(0.997)PAS(0.001)IAS(0.001)SSSTPSSK 62.325 0.012139 5314000.0 39975.0 42744.0 40897.0 44697.0 47295.0 38450.0 35209.0 36344.0 32816.0 49657.0 True False 37753.349532604 46022.32735637756 38265.731545286835 38609.1914933743 41353.379277335436 43746.13848565184 36846.28826530992 36449.7550229269 39380.11695564996 48223.27338561954 0.78288649612621 0.9543592569579004 0.7935116979573995 0.8006339840233199 0.8575398635146833 0.9071582125052754 0.7640768798639392 0.7558540195198866 0.8166205690921292 1.0 15.557441963648651 -7.269049044043512 24.830560267193384 0.813792378027561 0.8497415154504836 0.0 0.0805326410403619 2101.573916340957 6857457.406888133 0.03196925648504303 0.022071671532396617 5.3820900017342924e-08 7.269049044043512 0.035949137422922606 KDAPT(ph)SPASVASSSSTPSSK ddPTM_A459_Selumetinib_30min_R2 2 KDAPTSPASVASSSSTPSSK 20 1 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 KDAPT(0.496)S(0.496)PAS(0.007)VASSSSTPSSK;KDAPT(0.495)S(0.495)PAS(0.01)VASSSSTPSSK 75.319 0.007644800000000002 8068000.0 50816.0 48667.0 53880.0 56966.0 55552.0 38559.0 40109.0 42643.0 36059.0 53152.0 True False 47991.85015256548 52399.60241093082 50413.41946010843 49207.132528168775 48573.06111881884 43870.15224624836 41974.14797447573 42767.08407007133 43271.80757264083 51617.36365451901 0.9297617459461992 1.0151545662356456 0.9766755969470134 0.9533058072767492 0.9410217353199974 0.8499107497987765 0.8131788414343197 0.8285406507065408 0.8383188235312451 1.0 15.65556883753151 -6.652031932087701 3.08645518897765 0.8512812703391959 0.9710999847285735 0.4479790054037378 0.05325670295652645 0.19766043984936763 3.766165075097657 0.017990463645386208 0.0177816766220706 2.2282713065929575e-07 6.652031932087701 0.11981871438937763 KDAS(ph)SSPASTASSASSTSLK ddPTM_A459_Selumetinib_30min_R2 4 KDASSSPASTASSASSTSLK 20 1 A0A669KBK8;Q04724 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 KDAS(0.372)S(0.372)S(0.256)PASTASSASSTSLK;KDAS(0.362)S(0.362)S(0.27)PAS(0.004)T(0.001)ASSASSTSLK;KDAS(0.347)S(0.347)S(0.297)PAS(0.007)T(0.002)ASSASSTSLK;KDAS(0.333)S(0.333)S(0.333)PASTASSASSTSLK 98.7 0.00044261 59164100.0 211253.0 204600.0 218344.0 261939.0 238703.0 181488.0 204419.0 221464.0 162562.0 252503.0 True False 199512.40397276293 220292.16210730976 204295.98475497228 226262.45633002138 208714.99510810422 206486.324615968 213924.88854856382 222108.42357466108 195078.94236178588 245212.58230841768 0.8136303695942687 0.8983721798999527 0.8331382624486117 0.9227196019062281 0.8511594027650328 0.8420706746453105 0.8724058387815452 0.9057790651839505 0.7955502956876174 1.0 17.90367348269973 -10.725211825785857 4.046584622265343 1.000080976534179 0.8626506499425552 0.5383408655108113 0.03895066265506589 26093959.879473925 20977.09878864284 19759.4589647507 0.008757148920935227 1.882730569512535e-11 10.725211825785857 -0.13743032659162369 KDASSS(ph)PASTASSASSTSLK ddPTM_A459_Selumetinib_30min_R1 2 KDASSSPASTASSASSTSLK 20 1 A0A669KBK8;Q04724 A0A669KBK8 TLE1 Transducin-like enhancer protein 1 1 KDAS(0.007)S(0.214)S(0.777)PAS(0.002)T(0.001)ASSASSTSLK;KDAS(0.174)S(0.174)S(0.653)PASTASSASSTSLK 112.74 0.0001643 62096000.0 7104.4 7639.7 8922.1 9412.8 8215.400000000001 7300.7 7496.5 7614.6 4348.1 6548.6 True False 7269.9186972440175 6745.240372399828 7710.52782558722 7769.031180139346 7472.318520546677 7227.261586505225 6931.032969533225 7412.6360722933405 7378.408127340877 7389.176598765718 0.9838604613210055 0.9128541295827937 1.043489450079618 1.051406889021583 1.0112518520392173 0.9780875433011658 0.9379980132956869 1.0031748427194906 0.9985426696356615 1.0 12.851197893544782 -5.257487668984705 24.99873919069014 1.0019204612793011 0.9483572986605945 0.29384949561555884 0.03384622972802191 459.03902125536456 2903877.5432220493 0.009542012982521806 0.02331723258416704 5.527291014761954e-06 5.257487668984705 -0.05356316261870664 KDDDS(ph)DDESQSSHTGK ddPTM_A459_Selumetinib_30min_R1 1 KDDDSDDESQSSHTGK 16 1 O94874;O94874-3;O94874-2 O94874 UFL1 E3 UFM1-protein ligase 1 1 KDDDS(0.971)DDES(0.006)QS(0.022)S(0.001)HTGK 116.94 0.00096589 4125100.0 421.23 896.96 1119.4 726.11 588.62 608.8 587.83 791.8 532.81 641.81 True False 431.0438394291002 791.943506214609 967.3916284240629 599.3085192727966 535.3794249293013 602.676024746173 543.4895098353517 770.7988918711243 904.1396550972815 724.192565258807 0.595206109683074 1.0935537648492561 1.335820988549286 0.8275540899244386 0.7392777150894542 0.8322041037949522 0.750476511231682 1.064356262198938 1.2484796150512347 1.0 9.500229555598333 -7.958429139631139 9.026185308619253 1.1349991071373766 0.8984771176525455 0.20269238631260267 0.2022573014931252 0.4955757840674562 100.82649603275595 0.11870257291564364 0.056663111061412766 1.1004513825289216e-08 7.958429139631139 -0.23652198948483116 KDDDS(ph)DDESQSSHTGK ddPTM_A459_Selumetinib_30min_R2 1 KDDDSDDESQSSHTGK 16 1 O94874;O94874-3;O94874-2 O94874 UFL1 E3 UFM1-protein ligase 1 1 KDDDS(0.998)DDES(0.001)QSSHTGK 95.591 0.0044218 2332800.0 4516.7 3136.9 3198.2 3772.9 3842.2 5150.5 10064.0 24608.0 6946.9 13445.0 True False 4265.6798957826795 3377.490143276738 2992.4312939368747 3259.024511384475 3359.508486296189 5859.934623416119 10531.99594143767 24679.6052059263 8336.474112603746 13056.80791569475 0.3267015891882104 0.2586765590092563 0.22918551863965658 0.24960346605597306 0.25729937270946135 0.4488030046281273 0.8066286958834582 1.8901714236188258 0.6384771964503672 1.0 13.672514614329367 -7.356973010146411 2.9893380062483352 1.214422765527585 0.27698090443866363 0.6349674819800846 0.2996255780263446 0.15032503199649552 2.595072519441633 0.13080099034094672 0.08313809696198533 4.3956893223086624e-08 7.356973010146411 -0.9374418610889214 KDDEDEEEEEEVS(ph)DS ddPTM_A459_Selumetinib_30min_R2 1 KDDEDEEEEEEVSDS 15 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 KDDEDEEEEEEVS(0.587)DS(0.413) 111.07 0.0091605 0.0 33428.0 24537.0 28057.0 26395.0 27187.0 29130.0 37070.0 32986.0 28048.0 24894.0 True False 31570.205582886465 26418.909001109772 26251.843166151855 22799.955466085306 23771.52600513625 33142.39308418824 38793.82845281149 33081.98379887373 33658.38372659893 24175.245537620332 1.3058897595790064 1.0928083009538812 1.085897685105205 0.9431116399874877 0.9833002923649385 1.3709227082146351 1.604692220910122 1.3684239006959895 1.3922664683682902 1.0 14.56124292216194 -6.774405888766368 24.121464367005615 1.3863771645090712 1.0752689457773201 0.37711560846008907 0.16645569400601498 138.70803987793389 258034.93833316353 0.05776959913266361 0.051293045212037466 1.6811021796096394e-07 6.774405888766368 -0.3111082187317511 KDDEENYLDLFSHK ddPTM_A459_Selumetinib_30min_R2 1 KDDEENYLDLFSHK 14 1 Q07666-3;Q07666-2;Q07666 Q07666-3 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 0 67.93 0.04376 1484600.0 11395.0 9587.3 10134.0 9732.5 10684.0 7860.4 10811.0 7631.3 6719.3 9717.6 False True 10761.7115177992 10322.615081971708 9481.989473064934 8406.916710501051 9341.780403828143 8943.09875039317 11313.732921590092 7653.505819570273 8063.347752928415 9437.027638643018 1.1403708805229973 1.0938417770127493 1.0047644063516148 0.8908437097371805 0.9899070726014563 0.9476605444888926 1.1988661424771383 0.8110080962601479 0.8544372297809515 1.0 13.204116813079384 -5.268998311429025 2.684871576949237 0.9588661192768285 1.1305473411108709 0.2926873910315241 0.09925342191804264 0.37795817209566346 5.292844759421971 0.0279504204703415 0.08725715770483236 5.382718753554481e-06 5.268998311429025 0.17168122183404233 KDDPVTNLNNAFEVAEK ddPTM_A459_Selumetinib_30min_R1 1 KDDPVTNLNNAFEVAEK 17 1 O43707;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 172.32 7.7433e-07 14627000.0 1857.9 2050.4 2489.8 2297.4 2209.0 1869.4 2239.9 2047.9 1547.6 2110.9 False True 1901.185455155912 1810.3382147948998 2151.698835492435 1896.2022175391119 2009.1963400306267 1850.5955332793949 2070.9425396461656 1993.5830394832976 2626.1641677681614 2381.85457690721 0.7981954371137817 0.7600540487847867 0.9033712034117435 0.7961032700834709 0.8435428256243619 0.7769557181288356 0.8694664064399947 0.8369877232689517 1.1025711616610039 1.0 11.217869617436184 -8.250511202734636 23.255219175971387 1.051285566438251 0.8234507517980647 0.7917238190524543 0.04681744235781928 99.30622375837616 211327.01421266756 0.031051079148914584 0.011435615826620666 5.61679789498306e-09 8.250511202734636 -0.2278348146401863 KDDPVTNLNNAFEVAEK ddPTM_A459_Selumetinib_30min_R2 1 KDDPVTNLNNAFEVAEK 17 1 O43707;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 108.96 0.0030925 4589900.0 43270.0 34134.0 40296.0 40694.0 51038.0 33158.0 36141.0 36152.0 35349.0 37112.0 False True 40865.22662353409 36751.968041891065 37703.39923096749 35151.40699893448 44626.15015449089 37725.21352164481 37821.62811203291 36257.19633471423 42419.7877335833 36040.480131443954 1.1338702057934218 1.0197413549390082 1.0461403148198545 0.9753312628115131 1.2382229646146212 1.046745586741809 1.0494207617127433 1.0060131330792454 1.1770039571857325 1.0 15.137330610418969 -4.734161270425299 23.396319770036776 1.0636791347221568 1.133871009958049 0.07011930917886844 0.07824448799699629 3767.215118129854 3230739.7300239312 0.018942081403489033 1.4214744585447128 1.8443304204164415e-05 4.734161270425299 0.0701918752358921 KDDS(ph)DDDGGGWITPSNIK ddPTM_A459_Selumetinib_30min_R1 1 KDDSDDDGGGWITPSNIK 18 1 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 KDDS(1)DDDGGGWITPSNIK 147.08 0.00011726 204530000.0 10985.0 14800.0 9460.7 9786.6 9382.9 10292.0 11247.0 11461.0 6768.1 11712.0 True False 11240.92912691087 13067.209119666666 8175.988903905245 8077.55402723438 8534.218351685542 10188.471824388324 10398.629734988355 11157.017049425303 11484.971377534042 13215.349284540831 0.8505964454575851 0.9887902951572035 0.6186736898032219 0.6112251635061521 0.6457807635602016 0.7709574378262317 0.7868599997695526 0.8442468533523104 0.8690630213587344 1.0 13.689926935774912 -8.328769284419787 1.0271990495159584 0.9927209787593025 0.7440531889130826 0.34395897938163567 0.10813091973487865 0.6440227295857972 1.438226330171237 0.11476316232916538 0.038860504559733645 4.690625017894901e-09 8.328769284419787 -0.24866778984621996 KDDS(ph)DDDGGGWITPSNIK ddPTM_A459_Selumetinib_30min_R2 10 KDDSDDDGGGWITPSNIK 18 1 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK;KDDS(1)DDDGGGWITPSNIK 136.77 0.00017895 95318700.0 1275840.0 1041958.0 1145920.0 1177053.0 1152314.0 1022118.0 1251189.0 1235296.0 959066.0 1106931.0 True False 1204933.920392182 1121872.828176972 1072192.7547833598 1016736.3508703222 1007550.0135021354 1162905.4766366044 1309371.76768397 1238890.506845737 1150905.9985430087 1074971.025877867 1.1208989743776414 1.0436307594995904 0.9974154921131588 0.9458267491814603 0.9372810887431383 1.0818016938520985 1.2180530787931532 1.152487348051085 1.0706390877866965 1.0 20.035866344129005 -6.989604159063237 21.149461239088573 1.1268486113352298 1.0070555587800123 0.3039780817503791 0.07157801598096797 36.126981828711784 73494.4536735736 0.02614379822255147 0.023007263506634554 1.0242261054739417e-07 6.989604159063237 -0.11979305255521755 KDDVS(ph)PVMQFSSK ddPTM_A459_Selumetinib_30min_R1 1 KDDVSPVMQFSSK 13 1 Q8IZE3-2;Q8IZE3 Q8IZE3-2 SCYL3 Protein-associating with the carboxyl-terminal domain of ezrin 1 KDDVS(1)PVMQFSSK 100.45 0.0056055 29889000.0 4358.5 4993.8 5743.1 6190.5 5012.5 5196.7 4519.0 4286.9 2792.9 3827.8 True False 4460.044569835321 4409.123574445367 4963.218564590167 5109.445385076983 4559.1202600287515 5144.425916226075 4178.1281917322285 4173.197486186315 4739.347314654752 4319.13541592942 1.0326243889891051 1.020834762018357 1.1491231662441752 1.182978742975462 1.0555631673909187 1.1910777090370677 0.9673529050103079 0.9662113095123457 1.0972907441557742 1.0 12.076526834091306 -7.279982340046492 24.995322921166714 1.0048980135175885 1.1047775350719455 0.35417846705741407 0.06455301318945543 993.1341324768802 1338707.7359833927 0.02790130398848718 0.018850457848494876 5.2482880121580815e-08 7.279982340046492 0.09987952155435709 KDEETEESEYDS(ph)EHENSEPVTNIR ddPTM_A459_Selumetinib_30min_R2 3 KDEETEESEYDSEHENSEPVTNIR 24 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 KDEET(0.002)EES(0.007)EY(0.054)DS(0.935)EHENS(0.001)EPVTNIR;KDEET(0.002)EES(0.001)EY(0.022)DS(0.966)EHENS(0.009)EPVT(0.001)NIR;KDEETEESEYDS(1)EHENSEPVTNIR 136.92 3.7677e-08 33739500.0 66152.8 46673.8 70596.3 62529.8 69914.3 55635.5 55124.2 57513.3 55253.8 54388.8 True False 62476.29220664027 50253.53038007897 66054.21091743982 54013.13337007847 61131.04059222782 63298.7851162154 57687.5845265301 57680.654181160666 66306.10392016372 52818.45402492668 1.1828496944866231 0.9514388731704029 1.2505896307806883 1.022618597367276 1.157380345955945 1.1984217691480088 1.0921861609070482 1.0920549502251498 1.255358664774092 1.0 15.688754454564256 -5.2612873034295315 24.99999999159454 1.134589003147636 1.0671442996707747 0.070023162187834 0.0967831263903661 35.341258178622425 5808519.879662798 0.02317947521597517 0.054201432507602426 5.479143773982065e-06 5.2612873034295315 -0.06744470347686127 KDEGSY(ph)S(ph)LEEPK ddPTM_A459_Selumetinib_30min_R2 1 KDEGSYSLEEPK 12 1 P18827 P18827 SDC1 Syndecan-1 2 KDEGS(0.311)Y(0.769)S(0.919)LEEPK 104.59 0.043633 3392200.0 15048.0 10187.0 13848.0 16652.0 16647.0 15838.0 17953.0 19771.0 17534.0 12388.0 True False 14211.692401916835 10968.310143632287 12957.034756562382 14383.968873697755 14555.655033931764 18019.54073695068 18787.85007319461 19828.530336734744 21041.28994089365 12030.326252110568 1.1813222770599072 0.9117217533238582 1.0770310368174125 1.1956424599186801 1.2099135741541638 1.497843064213606 1.5617074449579886 1.648212186536178 1.749020724787262 1.0 13.554388147243795 -6.578027324138724 1.5514453576486846 1.5501804899646625 1.0591406038737787 0.46484009488280975 0.20087100269066738 0.29432323239516184 1.4555722256230506 0.07864385867508485 0.08286902655335253 2.6422425123541055e-07 6.578027324138724 -0.4910398860908838 KDELSDWSLAGEDDRDSR ddPTM_A459_Selumetinib_30min_R1 2 KDELSDWSLAGEDDRDSR 18 2 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2;H7C4S4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 ; 101.04 0.0016748000000000002 16391300.0 10740.099999999999 13640.1 9862.4 10676.2 11453.6 10738.6 12451.7 11435.7 6750.9 11754.4 False True 10990.323433403308 12043.11075088954 8523.140250285396 8811.80208709456 10417.62390229732 10630.579433868677 11512.45824407882 11132.388087611289 11455.784233772345 13263.191737551806 0.8286333825881916 0.9080100016040727 0.6426160775580135 0.6643802081323973 0.7854537662154211 0.8015098962771181 0.8680005892913265 0.8393445791854448 0.8637275597349479 1.0 13.695140375953265 -8.423564130361745 0.6140620066420979 0.9964889908802531 0.7650810779903925 0.46075898564427586 0.07417400894113241 0.8148270948693641 0.7294215652575197 0.08405322390582845 0.037049758317399414 3.770820588459219e-09 8.423564130361745 -0.23140791288986062 KDELSDWSLAGEDDRDSR ddPTM_A459_Selumetinib_30min_R2 2 KDELSDWSLAGEDDRDSR 18 2 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2;H7C4S4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 ; 72.523 0.012454 15997400.0 105833.0 90915.0 105869.0 115270.0 124525.0 92431.0 98819.0 105400.0 81960.0 105666.0 False True 99951.22554306655 97887.88816219996 99057.50380145176 99570.02714815906 108881.05623237534 105162.53124492291 103414.27930613374 105706.69655009068 98354.29015373804 102615.14802676122 0.9740396760622522 0.953932143982013 0.9653302237172464 0.9703248405604987 1.0610622147519586 1.024824631325361 1.0077876541109128 1.0301276037970848 0.9584773013053396 1.0 16.646884191443846 -6.0454578972852255 18.969424881877792 1.0154987824197443 0.9641243614256099 0.4724673030913731 0.02476241542288745 23.310771397486533 9727.255502941329 0.0072602112806064685 0.009375730028168855 9.006210693032976e-07 6.0454578972852255 -0.05137442099413447 KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_A459_Selumetinib_30min_R1 2 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 ; 89.29700000000003 1.1969e-06 66888000.0 14292.400000000001 18947.7 13465.3 14410.9 14709.7 12595.8 14642.2 14353.599999999999 8809.7 13224.5 False True 14625.385111830754 16729.294475453244 11636.786219598467 11894.306841096186 13379.210232208474 12469.097688071359 13537.727065497142 13972.895900936319 14949.417464969736 14921.993392538445 0.9801227441330991 1.1211165985248672 0.7798412660748996 0.7970990556157052 0.8966101163734987 0.8356187648700055 0.90723314971219 0.9363960654159845 1.001837829015861 1.0 13.865152654112562 -9.839831417184751 8.357513622376503 0.9999999999857698 0.9129865230726184 0.060017252416521116 0.09680526034864886 0.0 0.0 0.10038914865717036 0.02434794509783849 1.4460009650893554e-10 9.839831417184751 -0.08701347691315142 KDGS(ph)SPPLLEK ddPTM_A459_Selumetinib_30min_R2 2 KDGSSPPLLEK 11 1 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;Q6W2J9-3 H7BYY2 BCOR BCL-6 corepressor 1 KDGS(0.508)S(0.492)PPLLEK;KDGS(0.62)S(0.38)PPLLEK 91.592 0.013451 37941000.0 257490.0 255610.0 268910.0 294060.0 278940.0 219270.0 233420.0 216530.0 195552.0 275990.0 True False 243179.7366141388 275214.4650843083 251608.62336707092 254008.5207182053 243897.06344476028 249472.45216512054 244274.4925129552 217160.06645152895 234667.86417940247 268021.45159186254 0.9073144525179567 1.0268374544265924 0.9387630052471145 0.94771712939233 0.9099908309434934 0.930792855136879 0.9113990356448457 0.8102339016587962 0.8755562765056201 1.0 18.031988948502963 -6.4960295578568905 1.0437381046707672 0.8871849304491428 0.9649739908833326 0.15200208748641153 0.05295310385736166 0.7268857043773308 1.6931200494783272 0.02557672288719099 0.030486149351767158 3.1913206480834286e-07 6.4960295578568905 0.07778906043418976 KDHS(ph)VDSFK ddPTM_A459_Selumetinib_30min_R1 1 KDHSVDSFK 9 1 F8W7U3;Q641Q2-2;Q641Q2;A0A087WYF6;B1AP61 F8W7U3 FAM21A WASH complex subunit FAM21A 1 KDHS(1)VDSFK 76.221 0.029311 9544300.0 9727.7 13392.0 5278.9 4755.4 3588.5 9361.6 9312.9 6819.3 4657.9 6181.5 True False 9954.336483190793 11824.058414228102 4562.054374922085 3924.958659913593 3263.920808601134 9267.430803652709 8610.420455141199 6638.430011791812 7904.11610044412 6974.955737908911 1.42715407197338 1.6952162649526648 0.6540621254594208 0.5627216583728879 0.4679486051591284 1.3286723460170775 1.2344767162239512 0.9517522778978968 1.133213800552915 1.0 12.767968346492525 KDHS(ph)VDSFK ddPTM_A459_Selumetinib_30min_R2 1 KDHSVDSFK 9 1 F8W7U3;Q641Q2-2;Q641Q2;A0A087WYF6;B1AP61 F8W7U3 FAM21A WASH complex subunit FAM21A 1 KDHS(1)VDSFK 78.113 0.02685 4839700.0 53394.0 42067.0 50159.0 29367.0 35014.0 97824.0 55452.0 50171.0 57360.0 37673.0 True False 50426.5752331172 45293.40363327569 46931.82454898995 25367.163939099337 30615.228290868443 111298.368042143 58030.62787605348 50316.98930374383 68833.6027723086 36585.282603790896 1.3783295260890533 1.2380225164252927 1.2828061233597514 0.6933707254312924 0.8368181441270636 3.042162315581252 1.5861741046122315 1.3753341705369273 1.8814560903562951 1.0 15.158975782576166 KDIDHETVVEEQIIGENS(ph)PPDYSEYMTGK ddPTM_A459_Selumetinib_30min_R1 4 KDIDHETVVEEQIIGENSPPDYSEYMTGK 29 1 P25490;A0A494C032;H0YJU4;H0YJV7 P25490 YY1 Transcriptional repressor protein YY1 1 KDIDHETVVEEQIIGENS(0.993)PPDY(0.005)S(0.002)EYMTGK;KDIDHETVVEEQIIGENS(0.997)PPDY(0.002)S(0.001)EYMTGK;KDIDHET(0.001)VVEEQIIGENS(0.993)PPDY(0.001)S(0.002)EY(0.002)MT(0.001)GK;KDIDHETVVEEQIIGENS(0.999)PPDYSEYMTGK 131.42 6.8489e-14 32608500.0 5148.889999999999 6630.700000000001 5937.32 5625.9400000000005 5998.18 4655.86 6718.2 5567.120000000001 2453.32 4392.22 True False 5268.849119004104 5854.374561471202 5131.064555364265 4643.475190973266 5455.645678064694 4609.02627558265 6211.440765146146 5419.461893045687 4163.104856596653 4956.00422084579 1.063124421250982 1.1812690830340125 1.0353228784152648 0.93693931321568 1.1008153816974828 0.9299883676846576 1.2533162782670317 1.0935143820601516 0.8400123710722303 1.0 12.274961700831218 -1.5228787456660957 0.11459596929040519 0.9683866193185099 1.3652420468719806 0.06697485837620554 0.11296913484042259 362.04475152023053 2.887109643287958 0.940052505423612 22.803087129394175 0.029999999973352773 1.5228787456660957 0.3968554275534707 KDIDHETVVEEQIIGENS(ph)PPDYSEYMTGK ddPTM_A459_Selumetinib_30min_R2 2 KDIDHETVVEEQIIGENSPPDYSEYMTGK 29 1 P25490;A0A494C032;H0YJU4;H0YJV7 P25490 YY1 Transcriptional repressor protein YY1 1 KDIDHETVVEEQIIGENS(1)PPDYSEYMTGK;KDIDHETVVEEQIIGENS(0.996)PPDY(0.003)S(0.001)EYMTGK 93.876 3.0563e-07 7417200.0 71415.0 63353.0 73040.0 79062.0 81506.0 59795.0 61499.0 57553.0 56472.0 71237.0 True False 67446.04019689593 68211.97138799811 68340.68591993923 68293.6192104426 71266.48760711495 68031.2184850337 64358.82535795661 57720.46970158797 67767.97795951564 69180.20271404601 0.9749326765589545 0.9860042138059345 0.9878647826810093 0.9871844332797336 1.0301572532490622 0.9833914301500157 0.9303069784860504 0.8343495311826933 0.9795862877076589 1.0 16.078071620697706 -7.255001372571349 4.699212149225263 0.9215871220938501 0.9931999752948578 0.25947483110495206 0.04358923634993369 0.20642447858278687 12.968919771052388 0.017279196052781796 0.012377835800571777 5.5590250035871737e-08 7.255001372571349 0.07161285320100774 KDKS(ph)PVREPIDNLTPEER ddPTM_A459_Selumetinib_30min_R1 1 KDKSPVREPIDNLTPEER 18 3 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 KDKS(1)PVREPIDNLTPEER 61.524 0.031868 451130000.0 3332.0 5055.3 4460.6 4881.3 3284.4 3292.8 3579.0 3186.0 2241.1 3304.5 True False 3409.6291170566246 4463.423125854788 3854.875020321937 4028.8725883492884 2987.326599907915 3259.6774216231875 3309.033148530568 3101.4969304134897 3802.983016532195 3728.664763555768 0.9144370259248243 1.1970566969389687 1.033848646839951 1.0805134931216593 0.8011786495547295 0.8742211028150088 0.8874579396016749 0.831798278227568 1.0199315995642244 1.0 11.864443377912908 -6.24504416292534 24.612111073677397 0.8918620014210346 1.0648909423533262 0.40701714559582425 0.09031568654738854 586.3526855950261 880218.2021771854 0.025321679306377527 0.032587101971025115 5.687950877597603e-07 6.24504416292534 0.1730289409322916 KDKS(ph)PVREPIDNLTPEER ddPTM_A459_Selumetinib_30min_R2 1 KDKSPVREPIDNLTPEER 18 3 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 KDKS(1)PVREPIDNLTPEER 57.708 0.041727 86784000.0 128460.0 106350.0 103340.0 134430.0 104110.0 88937.0 89441.0 101470.0 84392.0 110890.0 True False 121320.70746612409 114506.70303085262 96691.21690808472 116120.40209531499 91030.77104479104 101187.26446029695 93600.18372397915 101765.26090073714 101272.75810949552 107688.31757317876 1.1265911679201557 1.0633159251748963 0.8978802816041671 1.0783008288378753 0.8453170510620317 0.9396308414934231 0.8691767671119374 0.9449981501622341 0.9404247405079609 1.0 16.716502223915874 -4.529333334010174 0.8758592723971128 0.9273841985813228 1.3368299639992995 0.4816288261484565 0.06406973947115445 2.6577752375607995 1.180365962578227 0.021508654480563896 1.1600811547861483 2.955742974534342e-05 4.529333334010174 0.4094457654179767 KDLYANTVLSGGTTMYPGIADR ddPTM_A459_Selumetinib_30min_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ; 130.49 3.2819e-05 67116000.0 3549.2999999999997 3614.7000000000003 3787.0 4128.3 4021.4 3606.7 3822.3 3273.8 2004.19 2692.5 False True 3631.9917842644277 3191.489243571562 3272.746200501988 3407.36990278868 3657.6650800358366 3570.4198726215855 3533.9808336486167 3186.9681891989 3400.964049753987 3038.10860217095 1.1954779304693404 1.0504855689790058 1.0772314716344809 1.1215431536429825 1.203928351153138 1.1752114029334766 1.163217414651777 1.0489974541797416 1.119434653298355 1.0 11.568957726922438 -8.741675194975326 1.003528167026889 1.0021768276153187 1.1343138582488272 0.36232470737426314 0.05270681002208995 1.0247300985786985 2.032130693448847 0.05406089122010516 0.01759280058100167 1.812695284654407e-09 8.741675194975326 0.13213703063350857 KDNDFIYHDR ddPTM_A459_Selumetinib_30min_R1 3 KDNDFIYHDR 10 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 ;; 97.214 0.014082 33974500.0 46644.0 54132.0 46789.6 49875.0 51146.0 44822.2 49711.3 46638.4 25661.6 43213.8 False True 47730.714446575366 47794.20027471594 40435.82931687559 41165.267519701876 46519.85333055973 44371.32936330143 45961.53661820276 45401.398129126384 43545.86095089132 48760.712168057566 0.9788764832241943 0.9801784705274512 0.8292706877928767 0.8442302355597802 0.9540437631473769 0.9099811588143384 0.9425936286531822 0.931106132589839 0.8930521933479385 1.0 15.573431576750844 KDNDFIYHDR ddPTM_A459_Selumetinib_30min_R2 2 KDNDFIYHDR 10 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 ; 87.363 0.02278 17254100.0 227941.0 198708.0 222841.0 224375.0 237870.0 186655.0 198720.0 215494.0 181546.0 199501.0 False True 215272.9517401198 213948.26465307584 208503.6526709355 193814.73793153572 207986.64401521918 212365.0319646122 207960.87375620977 216121.05186304785 217860.272819065 193740.88776415138 1.11113846036558 1.1043010441529706 1.0761984993315166 1.0003811800814821 1.0735299420554412 1.0961291362674705 1.073396928011236 1.1155159572002207 1.1244930036878695 1.0 17.56376893198953 KDNEESEQPPVPGT(ph)PTLR ddPTM_A459_Selumetinib_30min_R2 2 KDNEESEQPPVPGTPTLR 18 1 A0A2R8YDC1;A0A2R8Y6V8;O15439-4;O15439-3;O15439-2;O15439 A0A2R8YDC1 ABCC4 Multidrug resistance-associated protein 4 1 KDNEESEQPPVPGT(0.837)PT(0.163)LR;KDNEESEQPPVPGT(0.766)PT(0.234)LR 89.87700000000002 0.0074363 28907000.0 213650.0 55961.0 134089.0 162685.0 79004.0 74432.0 240900.0 160360.0 85321.0 83644.0 True False 201776.1883087143 60253.02875702429 125461.85972506471 140527.02235272134 69078.81121527869 84684.3323735771 252102.32733429444 160826.62105097284 102387.58406792425 81228.98038678872 2.484041869637104 0.7417676360101645 1.5445455443076093 1.7300109109282502 0.8504207597626553 1.042538413880551 3.1036007855060674 1.9799167770562103 1.260480970958695 1.0 16.309706914854985 KDPSGASNPS(ph)ADSPLHR ddPTM_A459_Selumetinib_30min_R2 1 KDPSGASNPSADSPLHR 17 1 P55317-2;P55317 P55317-2 FOXA1 Hepatocyte nuclear factor 3-alpha 1 KDPSGASNPS(0.872)ADS(0.128)PLHR 143.14 0.00025519 14042000.0 43686.0 36998.0 45672.0 48491.0 47619.0 32625.0 35999.0 36811.0 31891.0 41574.0 True False 41258.107008914034 39835.627632679636 42733.51324391373 41886.442148359245 41636.675500738704 37118.797609737085 37673.02483066524 36918.113915610906 38270.09110899053 40373.65059777569 1.0219067733049405 0.986673908424677 1.0584505639494501 1.0374697736812262 1.0312833960829046 0.9193817517156121 0.9331092005026854 0.9144110916154022 0.9478977140377528 1.0 15.301126421190558 -6.7561820845551335 24.999981861371143 0.9369949687316608 1.0272193192084822 0.695180520006339 0.027736251061150154 68.16180753450094 324128.9634563569 0.009132034113113245 0.008873316601641578 1.7531453149433023e-07 6.7561820845551335 0.09022435047682142 KDPSGASNPSADS(ph)PLHR ddPTM_A459_Selumetinib_30min_R1 1 KDPSGASNPSADSPLHR 17 1 P55317-2;P55317 P55317-2 FOXA1 Hepatocyte nuclear factor 3-alpha 1 KDPSGASNPS(0.331)ADS(0.669)PLHR 105.51 0.0013592 9352300.0 2213.8 2242.6 2899.0 2854.4 2873.9 2011.4 2513.7 2589.1 1401.7 2136.8 True False 2265.3772326950634 1980.0353494435444 2505.3317230671414 2355.932623724053 2613.956252428257 1991.167142205078 2324.089585208518 2520.428657417945 2378.582523882548 2411.0790941945725 0.9395698540747452 0.8212237226937512 1.0390914711589145 0.9771278882541423 1.0841437175255573 0.8258406565754878 0.963920922712362 1.0453529556482266 0.98652198080508 1.0 11.235463263238616 -5.264036665953122 24.997065918077173 0.9879423183396141 0.8803967887571118 0.2810304943738061 0.07020553381450395 277.5055510574013 2670825.381356866 0.018318502165447087 0.0411434244220425 5.444566843421881e-06 5.264036665953122 -0.1075455295825023 KDPSGASNPSADS(ph)PLHR ddPTM_A459_Selumetinib_30min_R2 3 KDPSGASNPSADSPLHR 17 1 P55317-2;P55317 P55317-2 FOXA1 Hepatocyte nuclear factor 3-alpha 1 KDPSGASNPS(0.035)ADS(0.965)PLHR;KDPSGASNPS(0.345)ADS(0.655)PLHR;KDPSGASNPS(0.344)ADS(0.656)PLHR 128.04 0.00053676 22425900.0 89349.0 84825.2 97686.0 94842.0 97555.0 71517.7 69752.1 72380.0 62820.0 88932.0 True False 84383.34027238606 91331.02008399312 91400.9891124749 81924.3559884244 85299.26874723454 81368.61400195835 72995.71086116403 72590.61381684587 75385.7553374553 86364.30208691438 0.9770627242198433 1.0575089229816317 1.0583190844348136 0.9485904940906978 0.9876681300729088 0.94215563648128 0.8452069790097231 0.840516417811064 0.8728809648874298 1.0 16.398147490034333 -6.717127675011745 1.388282857226813 0.8773066565183624 1.0214330793039739 0.5130821920777979 0.05260472207543153 0.2973349796185101 1.197932349043073 0.02383020685293684 0.022389994570467576 1.9181047683891353e-07 6.717127675011745 0.1441264227856115 KDS(ph)EEEVSLLGSQDIEEGNHQVEDGCR ddPTM_A459_Selumetinib_30min_R2 1 KDSEEEVSLLGSQDIEEGNHQVEDGCR 27 1 Q9Y487 Q9Y487 ATP6V0A2 V-type proton ATPase 116 kDa subunit a isoform 2 1 KDS(0.998)EEEVS(0.002)LLGSQDIEEGNHQVEDGCR 100.07 8.832799999999998e-07 6531200.0 60826.0 34647.0 45215.0 52841.0 39747.0 39526.0 61176.0 57480.0 38376.0 39960.0 True False 57445.53442577039 37304.3134923361 42305.91612636976 45643.964644190666 34753.626517311604 44970.34771869633 64020.80521794425 57647.257283673775 46052.27231502996 38806.25097145129 1.480316520862361 0.9612965065803412 1.090183026376165 1.1762013464730128 0.8955677409518097 1.1588428820856669 1.649754965122568 1.4855147261219153 1.186723044926689 1.0 15.244001442248914 -7.024424129151333 24.654927649109407 1.3757208124574578 1.1046393361806788 0.16093627343397465 0.2178892510844933 882.0310476199076 890363.4787709325 0.08030824236736069 0.06256080415427598 9.453135234239002e-08 7.024424129151333 -0.27108147627677903 KDS(ph)FQENEDGYR ddPTM_A459_Selumetinib_30min_R1 2 KDSFQENEDGYR 12 1 Q5VYS8-5;Q5VYS8-3;Q5VYS8-2;Q5VYS8-4;Q5VYS8-6;Q5VYS8 Q5VYS8-5 ZCCHC6 Terminal uridylyltransferase 7 1 KDS(1)FQENEDGYR;KDS(0.923)FQENEDGY(0.077)R 143.58 0.0014619 34363000.0 5210.1 6411.799999999999 5223.200000000001 6042.200000000001 4798.2 5618.1 5582.0 5281.4 3086.3999999999996 4750.0 True False 5331.485192910181 5661.103475235045 4513.918128983885 4987.043196141211 4364.203657191013 5561.587014826664 5160.945245906017 5141.320115595046 5237.395378262892 5359.708768918112 0.9947341213441289 1.0562334110511329 0.8421946645983613 0.9304690629949797 0.8142613424258782 1.03766589839345 0.9629152382001128 0.9592536343411905 0.9771790976098298 1.0 12.387938895596541 KDS(ph)ISEDEMVLR ddPTM_A459_Selumetinib_30min_R1 1 KDSISEDEMVLR 12 1 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 1 KDS(0.981)IS(0.019)EDEMVLR 79.337 0.021683 7327300.0 2751.7 2674.0 3248.9 2994.3 2518.4 2819.1 2987.9 2462.1 1883.2 2760.9 True False 2815.809256123862 2360.9268368911266 2807.717224930264 2471.401714972298 2290.611164659632 2790.742413538002 2762.5202974279096 2396.7971099720826 3195.6528565139556 3115.2884084433713 0.9038679207010719 0.7578517707998729 0.9012703983748354 0.7933139378922522 0.7352806110828727 0.89582152521553 0.8867622946050986 0.7693660411909342 1.0257967923139226 1.0 11.605150016505311 -8.270737463800108 24.97931548158172 1.012898436669034 0.8300301343339087 0.5860471403125738 0.061337086731487085 492.40348718904136 1322826.5364207854 0.05482257500943682 0.014928208224517597 5.361206509094221e-09 8.270737463800108 -0.1828683023351252 KDS(ph)ISEDEMVLR ddPTM_A459_Selumetinib_30min_R2 1 KDSISEDEMVLR 12 1 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 1 KDS(0.975)IS(0.025)EDEMVLR 72.66199999999998 0.029037 6201100.0 17439.0 14748.0 15397.0 14422.0 13720.0 10001.0 14184.0 11896.0 9966.7 13752.0 True False 16469.810193848192 15879.124177705797 14406.373782986067 12457.698720662325 11996.37094164377 11378.546969961095 14843.584105062806 11930.615390511188 11960.318492865561 13354.944028012971 1.2332369315289948 1.1890071680119492 1.0787296264789763 0.9328154947359864 0.8982718996410997 0.8520100830144822 1.111467339281041 0.8933482136267924 0.8955723414323503 1.0 13.705086309047195 -5.478195752368731 2.162270652198156 0.9368605756090708 1.2212680238420648 0.7128234993735889 0.06926787289411604 0.17379920246766883 1.5772938490078827 0.02035626917968677 0.053586608701246354 3.325096452829087e-06 5.478195752368731 0.284407448232994 KDS(ph)LDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHR ddPTM_A459_Selumetinib_30min_R1 1 KDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHR 41 1 H0YLG5;Q96TC7;H0YMB1;Q96TC7-2 H0YLG5 RMDN3 Regulator of microtubule dynamics protein 3 1 KDS(1)LDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHR 74.631 8.890600000000002e-09 1761700.0 119.26 217.06 135.98 0.0 215.69 171.3 78.096 180.0 0.0 217.29 True False 122.03852596043602 191.64651429154367 117.51466288467392 0.0 196.18087758316236 169.57687752795567 72.20515584454967 175.2258152775984 0.0 245.1812880838351 0.49774812308966765 0.7816522859037014 0.47929702875405406 0.0 0.800146206573815 0.6916387414930786 0.2944970083518791 0.7146785819058232 0.0 1.0 7.937705068400628 -11.717502235855376 2.501260117456862 2.5754215537346505 0.48649658352788455 0.23898984775358023 0.28107711494705845 26170526.88010308 3867986.534075525 235045895.6416021 0.07116665793041549 1.9164511963453717e-12 11.717502235855376 -2.088924970206766 KDS(ph)LESDSSTAIIPHELIR ddPTM_A459_Selumetinib_30min_R2 1 KDSLESDSSTAIIPHELIR 19 1 Q9UMX1-2;Q9UMX1-3;Q9UMX1 Q9UMX1-2 SUFU Suppressor of fused homolog 1 KDS(0.498)LES(0.498)DS(0.001)S(0.002)T(0.002)AIIPHELIR 73.953 0.0071081999999999985 3166100.0 26808.0 21702.0 24638.0 27623.0 27542.0 19518.0 29964.0 24653.0 20651.0 21903.0 True False 25318.118680926786 23366.47361707155 23052.81790382613 23860.69974766714 24081.927731395986 22206.427333236723 31357.3853725396 24724.736148476135 24781.7770371504 21270.6034791716 1.1902868061885763 1.0985336471507379 1.083787675624704 1.1217688191607627 1.1321694635968962 1.0439961120511456 1.474212304471995 1.16238997039679 1.1650716474225558 1.0 14.376573344867658 KDS(ph)LPDADLASCGSLSQSSASFFTPR ddPTM_A459_Selumetinib_30min_R2 1 KDSLPDADLASCGSLSQSSASFFTPR 26 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 KDS(1)LPDADLASCGSLSQSSASFFTPR 95.209 2.1905e-06 5008900.0 37432.0 34933.0 36106.0 42097.0 33060.0 24222.0 36862.0 48625.0 44023.0 72424.0 True False 35351.67929216844 37612.24877270115 33782.97926924042 36363.31597862446 28906.70723985007 27558.360634576282 38576.156040667316 48766.49069969793 52828.83010539307 70332.93093984961 0.5026333869464651 0.5347743691339699 0.4803294675453299 0.5170169292350866 0.4109981889503762 0.39182727445476206 0.5484792902155401 0.6933663939215642 0.7511251045484445 1.0 16.101912718628057 -8.293385100672156 1.1007006439515512 0.9865066416954826 0.4743261110977131 0.9114397370325223 0.052000831800940873 0.13705259521668436 0.3419029655123041 0.05394188560893788 0.01790077091769966 5.0887943376817784e-09 8.293385100672156 -0.5121805305977696 KDS(ph)SSEVFSDAAK ddPTM_A459_Selumetinib_30min_R1 1 KDSSSEVFSDAAK 13 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3;A0A1B0GTZ9 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 KDS(0.837)S(0.157)S(0.006)EVFSDAAK 141.13 0.0015175 7243600.0 1322.0 1513.3 1321.1 1670.4 1243.1 1529.9 1619.3 1747.1 1232.3 1352.4 True False 1352.8000278357918 1336.122132485917 1141.7018762828563 1378.695997291429 1130.6618244871302 1514.5105950380587 1497.1548972940905 1700.7612326194005 2091.1230963690264 1525.9937134915494 0.8865043255915636 0.8755751224091239 0.7481694493161349 0.9034742313170505 0.7409347853079419 0.9924749896726528 0.9811016153326908 1.1145270243138645 1.3703353283051427 1.0 10.575533303496885 -7.464229782628546 1.4738162732028888 1.1901530326072922 0.8381928923784209 0.6301656446218376 0.10601933282874754 0.2488892787490467 1.0402879560100582 0.06785392545615854 0.03378404358535083 3.433762215114668e-08 7.464229782628546 -0.35196014022887134 KDS(ph)SSEVFSDAAK ddPTM_A459_Selumetinib_30min_R2 2 KDSSSEVFSDAAK 13 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3;A0A1B0GTZ9 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 KDS(0.934)S(0.066)SEVFSDAAK;KDS(0.963)S(0.036)S(0.001)EVFSDAAK 172.42 0.0003164 12573100.0 38555.0 34663.0 41036.0 35411.0 34246.0 23344.0 34370.0 36219.0 35563.0 52226.0 True False 36412.267447893646 37321.54064088797 38395.788436618575 30587.960712617773 29943.711316875568 26559.42410426674 35968.27310286297 36324.391293621775 42676.59371324289 50718.09968055591 0.7179343799794066 0.7358623622721445 0.7570431202756319 0.6030975313600808 0.5903949774434325 0.5236675717652919 0.7091802202646866 0.7162017410432999 0.8414470175743604 1.0 15.63021307075235 -8.449238325128942 1.5080619786571112 0.9979984524932992 0.6584999543423636 0.7116485457985859 0.06874992078805618 0.23714132076648192 1.1699768057651496 0.07423101098793956 0.02204755796149624 3.5543621448142575e-09 8.449238325128942 -0.3394984981509356 KDSETGENIR ddPTM_A459_Selumetinib_30min_R2 1 KDSETGENIR 10 1 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 93.442 0.034115 5498100.0 42797.0 27231.0 29855.0 39551.0 27587.0 27514.0 53275.0 45997.0 32044.0 34802.0 False True 40418.5140699651 29319.53013853449 27934.16180366623 34164.08557071945 24121.274429090856 31303.80375277568 55752.393062409814 46130.84365478674 38453.69538416772 33797.17583354472 1.1959139505925374 0.8675142054157663 0.8265235515903884 1.010856224762146 0.7137068063879396 0.9262254309931336 1.6496169187921872 1.364931906795611 1.137778362711634 1.0 15.044615076318202 -7.147093221767332 9.898549084879319 1.3181716114718096 0.9096701603515646 0.4495436038002577 0.1962505851540822 0.3281442340403186 26.378000848473558 0.07363246323189046 0.05703168826686329 7.127000318950257e-08 7.147093221767332 -0.40850145112024505 KDSGSSSVSSTSSSSSS(ph)SPGDK ddPTM_A459_Selumetinib_30min_R2 2 KDSGSSSVSSTSSSSSSSPGDK 22 1 Q9H7S9 Q9H7S9 ZNF703 Zinc finger protein 703 1 KDSGSSSVSSTSSS(0.001)S(0.232)S(0.232)S(0.459)S(0.075)PGDK;KDSGSSSVSSTSSS(0.003)S(0.05)S(0.027)S(0.46)S(0.46)PGDK 208.16 1.1824999999999999e-23 7201200.0 36796.0 32638.0 38315.0 34501.0 30841.0 24658.5 35340.0 37011.0 22342.0 35144.0 True False 34751.02562605874 35141.22965228923 35849.85461421777 29801.90428245534 26966.47785796176 28054.984547423803 36983.38002488152 37118.695882499094 26811.024287638094 34129.30140492202 1.0182167286039747 1.0296498376969787 1.0504127872083435 0.8732058101299841 0.7901268630735213 0.8220204748573553 1.0836254626515118 1.087590262751348 0.7855720212243047 1.0 15.058723263661895 -5.751799459171192 24.98585044641715 0.9212410714428407 1.0324488180082771 0.19655571848730413 0.10417579272951998 370.23468067406304 959607.1347297179 0.030839155186555806 0.05256054666635413 1.7709265166861879e-06 5.751799459171192 0.11120774656543642 KDSNELS(ph)DSAGEEDSADLKR ddPTM_A459_Selumetinib_30min_R1 1 KDSNELSDSAGEEDSADLKR 20 2 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 KDS(0.093)NELS(0.864)DS(0.025)AGEEDS(0.018)ADLKR 63.272 0.02347 8674800.0 1460.0 1512.1 1549.5 1625.5 2132.5 1505.2 2073.2 1640.3 820.83 1115.9 True False 1494.0151593345345 1335.0626290437817 1339.0864107942516 1341.6369394140431 1939.615751523454 1490.0590546122517 1916.8168548571045 1596.7939155546921 1392.888558948785 1259.1366347864678 1.1865393461352975 1.060300043823433 1.063495711107907 1.0655213281452702 1.5404331014897252 1.1833974276071677 1.5223263321078497 1.2681657188264452 1.1062251073212557 1.0 10.298219129778692 KDSS(ph)SEVFSDAAK ddPTM_A459_Selumetinib_30min_R2 2 KDSSSEVFSDAAK 13 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3;A0A1B0GTZ9 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 KDS(0.335)S(0.634)S(0.03)EVFS(0.001)DAAK;KDS(0.117)S(0.872)S(0.011)EVFSDAAK 159.64 0.00065406 10988500.0 48023.0 39423.0 40170.0 42301.0 41267.0 32454.0 33704.0 42032.0 35689.0 57788.0 True False 45354.07391130066 42446.61733507566 37585.50593378907 36539.53082670482 36082.67052833919 36924.24391192053 35271.30278320899 42154.30616122783 42827.797233977064 56119.51028874444 0.8081694526189951 0.7563611499223815 0.6697404474915273 0.6511020969125124 0.642961250778699 0.6579573435680213 0.6285033957305067 0.751152423539278 0.7631534383251164 1.0 15.776214799286263 -8.794713103151475 1.3748162516938085 0.9992543791412635 0.6874983317505527 0.7373964761555083 0.05473631981450211 0.5242070389946862 1.7215396676561652 0.05742106613143874 0.01700616449317722 1.6043048515637908e-09 8.794713103151475 -0.3117560473907107 KDY(ph)ELRQKK ddPTM_A459_Selumetinib_30min_R1 1 KDYELRQKK 9 3 P25092 P25092 GUCY2C Heat-stable enterotoxin receptor 1 KDY(1)ELRQKK 52.255 0.041163 2419800.0 5543.4 5509.1 3917.1 3573.0 5261.3 4598.1 5527.4 6574.5 2215.8 4420.3 True False 5672.550434421274 4864.092010888896 3385.1793350901353 2949.042623516688 4785.4163439579615 4551.847288740765 5110.463767864731 6400.122903014278 3760.0507643710857 4987.688562368154 1.1373104722737435 0.9752196734150991 0.6787070388939547 0.5912643876297847 0.9594456999708592 0.9126165821747998 1.0246156519119718 1.2831841489267928 0.753866388679612 1.0 12.284155668924608 -6.951682111640055 2.1758275929061015 1.0352142283368497 0.8455854326710366 0.11597181322128891 0.18655158924127432 0.6120187401892909 5.864125808987361 0.08287750433667507 0.06722464989960977 1.1176810518518977e-07 6.951682111640055 -0.18962879566581314 KEAESSPFVER ddPTM_A459_Selumetinib_30min_R2 1 KEAESSPFVER 11 1 P14625 P14625 HSP90B1 Endoplasmin 0 92.112 0.034458 3604200.0 14476.0 11503.0 11773.0 12667.0 14201.0 9561.3 12278.0 11820.0 7677.1 10884.0 False True 13671.481872019414 12385.243112025342 11015.537997473206 10941.732748206197 12416.943421449207 10878.282286160278 12848.951328395453 11854.394243093664 9212.734516096421 10569.750639971866 1.2934535863426768 1.171763037170223 1.0421757686331308 1.0351930826851863 1.1747621911241473 1.0291900591317293 1.215634291295793 1.121539632000743 0.8716132319391163 1.0 13.367653720818812 -4.929778425695133 2.7668234146014483 1.0734416629691208 1.30331590213144 0.3861355855353529 0.09154407645031791 0.35974891877812426 4.700283819620178 0.023714913479470176 0.16331727410339927 1.1754971331975906e-05 4.929778425695133 0.2298742391623192 KECDEELQDT(ph)MLLLSQMGPDAHMR ddPTM_A459_Selumetinib_30min_R2 1 KECDEELQDTMLLLSQMGPDAHMR 24 1 B7Z278;E9PB94;Q8WZA2-5;Q8WZA2-4;Q8WZA2-3;Q8WZA2 B7Z278 RAPGEF4 Rap guanine nucleotide exchange factor 4 1 KECDEELQDT(0.988)MLLLS(0.012)QMGPDAHMR 44.632 0.021629 28013000.0 25644.0 19853.0 23199.0 18428.0 20412.0 19706.0 47542.0 34350.0 18784.0 18870.0 True False 24218.8091410656 21375.661262543617 21706.40159716138 15918.074609926882 17847.66207440472 22420.322626742633 49752.79720268581 34449.95281305138 22541.324868811822 18325.174069851997 1.3216141384932123 1.1664642955676032 1.1845127099159223 0.8686452062747279 0.9739422941562742 1.2234711954866417 2.7149972498508244 1.879924997259773 1.2300742564784748 1.0 14.16153928205694 -7.026726676254837 24.982913207485407 1.8066702775796186 1.098128459480887 0.2883946980444154 0.4408816952307193 799.1828442341235 747038.4760770637 0.16653408669859573 0.1294120187451152 9.403149126833371e-08 7.026726676254837 -0.7085418180987315 KECSEAMEVETSVIS(ph)IDSPQK ddPTM_A459_Selumetinib_30min_R1 1 KECSEAMEVETSVISIDSPQK 21 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 KECSEAMEVET(0.001)S(0.067)VIS(0.831)IDS(0.101)PQK 153.34 4.2059e-07 6373200.0 3763.8 4690.5 3841.9 2845.3 3897.2 3670.5 3530.3 3882.9 2615.5 3344.7 True False 3851.4892169200834 4141.334079445711 3320.1910820461017 2348.4217678958967 3544.6989481065434 3633.5781025473525 3264.0066287391624 3779.91287856326 4438.312471438112 3774.0248251369285 1.0205256709672927 1.0973256063029357 0.8797480768891442 0.6222592263448324 0.9392357264046177 0.9627859568770907 0.8648609322861935 1.001560152277514 1.1760157065943735 1.0 11.881888197527351 -7.992408902685452 5.484403248587599 1.0898299273739438 0.910897198603049 0.2476687255558887 0.12339358582837667 0.23823880240636364 23.831340657161313 0.08162376185081845 0.03513106837588824 1.0176328017577418e-08 7.992408902685452 -0.17893272877089483 KECSEAMEVETSVISIDS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 KECSEAMEVETSVISIDSPQK 21 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 KECSEAMEVETSVIS(0.118)IDS(0.882)PQK 117.94 0.0004568 0.0 2333.1 3094.0 2161.8 1978.1 1907.0 1917.1 2124.5 2160.2 1426.6 2126.7 True False 2387.4566905776733 2731.753041638423 1868.2394339174 1632.6619685357862 1734.5121867081946 1897.815714587528 1964.2472545552382 2102.9044786814884 2420.8360052585026 2399.682660812241 0.9949051720736984 1.138380956052657 0.7785360391298745 0.6803657813584256 0.7228089843017408 0.7908611190886207 0.8185445878457874 0.8763260713688286 1.0088150590874803 1.0 11.228627918019665 -10.745091438266291 16.208255544039027 0.9999999999999897 0.859836907354912 0.07687592779973729 0.13503913816996285 0.0 0.0 0.14578406648879058 0.03535782968619716 1.7984922128194897e-11 10.745091438266291 -0.14016309264507765 KEDESQMEDPS(ph)TSPSPGTR ddPTM_A459_Selumetinib_30min_R1 1 KEDESQMEDPSTSPSPGTR 19 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314 Q9UI08-4 EVL Ena/VASP-like protein 1 KEDESQMEDPS(0.229)T(0.229)S(0.229)PS(0.229)PGT(0.083)R 75.10600000000002 0.0048698 13393000.0 3065.2 3614.9 3591.0 3893.3 3533.2 3193.9 2996.2 3364.3 1955.9 2829.4 True False 3136.61319615905 3191.665827478582 3103.3619239510545 3213.408241292341 3213.622683837123 3161.772265829175 2770.1942217455417 3275.0678352134673 3319.0194467160413 3192.5810506898765 0.9824694021413387 0.9997133281201751 0.9720542328222042 1.0065236215688131 1.0065907905901714 0.9903498816877196 0.8676973827013531 1.025837021273357 1.0396038171055495 1.0 11.640507531040846 KEDESQMEDPS(ph)TSPSPGTR ddPTM_A459_Selumetinib_30min_R2 2 KEDESQMEDPSTSPSPGTR 19 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314 Q9UI08-4 EVL Ena/VASP-like protein 1 KEDESQMEDPS(0.308)T(0.211)S(0.211)PS(0.211)PGT(0.06)R;KEDESQMEDPS(0.347)T(0.347)S(0.225)PS(0.069)PGT(0.013)R 94.671 0.00092197 17685700.0 87612.0 80551.0 111779.0 113451.0 126936.0 95202.6 87136.0 94447.0 85436.0 106707.0 True False 82742.87577862431 86729.00268771235 104587.2608357732 97998.77808610866 110989.16485776192 108315.8939868431 91187.99665670832 94721.8251334575 102525.58728129293 103626.09165191806 0.7984753111847462 0.8369417518807585 1.0092753588264596 0.9456959779520427 1.071054240186695 1.045256964343287 0.8799713971941591 0.9140731221595219 0.9893800455746055 1.0 16.661027774348554 -5.176000574735473 4.6500725963586085 0.9792315249616544 0.808792891887547 0.5924109161005584 0.05463599898313826 0.163946521183784 6.179347986503391 0.015361123225655778 0.043971396436418404 6.668058867772429e-06 5.176000574735473 -0.17043863307410745 KEDESQMEDPSTS(ph)PSPGTR ddPTM_A459_Selumetinib_30min_R1 1 KEDESQMEDPSTSPSPGTR 19 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314 Q9UI08-4 EVL Ena/VASP-like protein 1 KEDESQMEDPS(0.177)T(0.126)S(0.335)PS(0.335)PGT(0.026)R 62.005 0.023893 3235700.0 1438.3 1661.2 1630.9 1802.9 1497.6 1442.1 1501.8 1405.1 776.05 1172.5 True False 1471.8095915553838 1466.7059317290723 1409.432737892446 1488.0573596244717 1362.1423444227541 1427.5937833220366 1388.518016893884 1367.8321835919646 1316.9001695505822 1323.0017961171557 1.1124773948719953 1.108619758517086 1.0653294213424005 1.1247583820307223 1.029584652432424 1.0790565723431709 1.0495208857380316 1.033885356472214 0.995388043625881 1.0 10.369599304893608 -7.162774986827274 0.43945188110295436 0.9917831952917258 1.1142199909828796 0.7225672961023502 0.023076269235219184 0.5902945524645326 0.2550661489218201 0.02291375826853835 0.02576108196216825 6.874245106364533e-08 7.162774986827274 0.12243679569115384 KEDESQMEDPSTS(ph)PSPGTR ddPTM_A459_Selumetinib_30min_R2 1 KEDESQMEDPSTSPSPGTR 19 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314 Q9UI08-4 EVL Ena/VASP-like protein 1 KEDESQMEDPS(0.126)T(0.126)S(0.358)PS(0.358)PGT(0.031)R 78.531 0.0053142 2789700.0 22916.0 21684.0 21875.0 27485.0 26483.0 18444.0 18491.0 23882.0 20645.0 24199.0 True False 21642.42046001635 23347.093074950666 20467.58631569918 23741.495585730412 23155.968778976097 20984.493582038027 19350.86813922138 23951.492666122074 24774.576869496395 23500.311993447194 0.9209418354127001 0.9934801325812503 0.8709495568146646 1.0102629953317415 0.9853472917905467 0.892945318678719 0.8234302652925272 1.0191989226696516 1.0542233173927442 1.0 14.520392289889136 -7.964154704888365 24.99979689565586 1.0303117138853626 0.9317030487048891 0.3819995884883236 0.05602525382136986 175.99219631202223 122743.20568301147 0.03165937481945754 0.015208563708330717 1.0860386847325629e-08 7.964154704888365 -0.09860866518047351 KEDEVEEWQHR ddPTM_A459_Selumetinib_30min_R2 4 KEDEVEEWQHR 11 1 P15311;E7EQR4 P15311 EZR Ezrin 0 ;;; 144.17 0.00052559 29140300.0 348065.0 269624.0 310071.0 300691.0 303064.0 301037.0 359688.0 340436.0 324531.0 314472.0 False True 328720.94071459223 290303.2938221959 290121.3694397785 259736.36707909283 264990.3908934639 342502.1142081964 376414.2047082511 341426.6123977862 389446.26815376745 305392.3762636199 1.0763888239005504 0.9505911620125093 0.949995454992435 0.8505004946648831 0.8677046694339209 1.121514945456735 1.2325592711696376 1.1179932406140383 1.2752324498683318 1.0 18.220304521954837 -6.870080845056046 5.510326819737623 1.167246478096446 0.9360713510191481 0.5838977291476493 0.08881591685530969 0.14221924191703852 6.37277086248699 0.03130405258409901 0.0276395346264311 1.348711792986789e-07 6.870080845056046 -0.23117512707729793 KEDGTFYEFGEDIPEAPER ddPTM_A459_Selumetinib_30min_R2 2 KEDGTFYEFGEDIPEAPER 19 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 ; 149.12 4.4697e-05 7391400.0 59102.0 51876.0 58145.0 72357.0 73825.0 54651.0 55546.0 54427.0 46461.0 57331.0 False True 55817.34744405163 55854.722392369564 54404.01400348929 62501.85177721295 64550.443496126245 62178.679177616585 58128.999062310926 54585.37355912512 55754.49822880463 55675.70506617302 1.002544060783968 1.0032153580450176 0.9771589589898814 1.1226054830006509 1.15940055755747 1.1168009296642853 1.0440639951163988 0.9804163861822317 1.001415216251648 1.0 15.764760302684302 -7.630603969413098 4.936767308194266 0.9938287834334981 1.0651673660138874 0.23921679250119776 0.05539394771833402 0.3573676300756407 14.015819434260068 0.031789382035502765 0.017782087009055172 2.3409709833251743e-08 7.630603969413098 0.07133858258038928 KEDLEAEEEYSSLCELLGSPEQRPGMQDPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KEDLEAEEEYSSLCELLGSPEQRPGMQDPLSPK 33 2 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2;A8MXE8;Q7Z5J4-4 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 KEDLEAEEEYSS(0.001)LCELLGS(0.192)PEQRPGMQDPLS(0.807)PK 71.289 2.7658e-05 17313000.0 3228.3 4057.5 4075.2 4495.3 2760.8 3575.7 3692.1 3748.5 2377.6 3241.1 True False 3303.5131088216986 3582.446013719425 3521.810223471271 3710.2802422318987 2511.0861274588297 3539.7317044758365 3413.601924473236 3649.077603155988 4034.6135469666433 3657.126755987473 0.9033083426526478 0.9795793946311048 0.962999222738271 1.014534220384186 0.6866281359670299 0.9678996492753672 0.9334108857136175 0.9977990500826074 1.103219498848692 1.0 11.836494916007858 -7.879297901900638 2.777406333239807 1.0525776278052579 0.9201401715712898 0.26870173611742654 0.08778046449124627 0.3763310617539055 5.687370427134256 0.06095472404239702 0.024704311033197698 1.3203896095225239e-08 7.879297901900638 -0.13243745623396808 KEDLVFIFWAPESAPLK ddPTM_A459_Selumetinib_30min_R1 2 KEDLVFIFWAPESAPLK 17 1 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;Q9Y281-3;Q9Y281 P23528;Q9Y281 CFL1;CFL2 Cofilin-1;Cofilin-2 0 ; 103.88 0.004064 25650000.0 12912.6 13205.099999999999 13840.0 14071.2 13091.599999999999 13267.7 12035.599999999999 12342.4 9628.099999999999 11005.8 False True 13213.438456454183 11659.040753115558 11960.604017678246 11613.929069137432 11907.467091509707 13134.238984107753 11127.745002082844 12015.039458234618 16338.182491398704 12418.501635570305 1.0640122974745152 0.9388444029125523 0.9631277885747099 0.9352117839942674 0.9588489369283616 1.0576347589702257 0.8960618058952984 0.967511203108429 1.315632350089745 1.0 13.600203494063019 -8.219702516050873 24.541572640830545 1.1578161911896574 0.96978289738583 0.4248692746616791 0.08611920776852323 288.7761533595503 169802.83203292804 0.053264460759247734 0.020131583876880434 6.029724700019255e-09 8.219702516050873 -0.18803329380382738 KEEASS(ph)PGAGEGPAEEGTR ddPTM_A459_Selumetinib_30min_R1 1 KEEASSPGAGEGPAEEGTR 19 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 KEEAS(0.108)S(0.892)PGAGEGPAEEGTR 61.111 0.018869 9769900.0 7176.2 5080.2 9821.0 10139.0 7427.8 7672.3 5689.0 6435.8 4807.4 4730.0 True False 7343.391497545539 4485.407822279095 8487.362142891472 8368.41398260165 6755.956801484601 7595.123627891034 5259.874149759821 6265.101677575379 8157.806681396128 5337.141574101616 1.3759034486136201 0.8404138732321541 1.5902448951469161 1.5679580289211794 1.2658380347764728 1.423069544331789 0.9855226953849727 1.1738683695363585 1.5284973366608332 1.0 12.381851565717627 -7.226088642055352 24.824413062355408 1.1864608744254517 1.3388517333844774 0.10927258675225837 0.23879203792648207 1532.7579273960769 1076352.7101248745 0.09392909813746844 0.07275455775954998 5.941708724724033e-08 7.226088642055352 0.1523908589590257 KEEELQAALAR ddPTM_A459_Selumetinib_30min_R1 1 KEEELQAALAR 11 1 P35579;A0A0C4DFM8;P35749-4;P35749-3;P35749;P35749-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-4;Q7Z406-5 P35579;P35749-4;Q7Z406 MYH9;MYH14;MYH11 Myosin-9;Myosin-11;Myosin-14 0 113.67 0.0094223 2607400.0 4472.4 3829.0 4345.8 4666.5 4461.4 3882.2 3633.5 3851.5 2946.7 3557.4 False True 4576.598218224503 3380.698899946194 3755.6642297706735 3851.5833760539126 4057.8671577241425 3843.148592755571 3359.4221696523655 3749.3457085648333 5000.334681547192 4014.0269420103773 1.1401513453550387 0.8422212777308893 0.935635032855483 0.9595310225109982 1.0109217542251494 0.9574296954844992 0.8369206829413653 0.9340609225425424 1.245715276400919 1.0 11.970834584714465 -8.235747123373379 24.854562922144275 1.1228576543001798 0.946442475126388 0.3274389341664684 0.09761553424413281 644.0947999209162 623096.1857325893 0.06262926423908982 0.02365342251364596 5.811026776599428e-09 8.235747123373379 -0.1764151791737918 KEEENADS(ph)DDEGELQDLLSQDWR ddPTM_A459_Selumetinib_30min_R1 4 KEEENADSDDEGELQDLLSQDWR 23 1 J3QQQ3;Q96NB3 J3QQQ3 ZNF830 Zinc finger protein 830 1 KEEENADS(1)DDEGELQDLLSQDWR;KEEENADS(1)DDEGELQDLLSQDWR;KEEENADS(1)DDEGELQDLLSQDWR;KEEENADS(1)DDEGELQDLLSQDWR 173.19 4.6781e-13 43573400.0 8397.2 9333.2 9993.0 9984.9 8807.0 9094.400000000001 8426.7 8472.5 4834.3 7962.9 True False 8592.83842189312 8240.464605113033 8636.005487619843 8241.224654786398 8010.408405002135 9002.918593054525 7791.067234624904 8247.781777441398 8203.454016697868 8985.01578021433 0.9563520679412926 0.9171341271608167 0.9611564073862805 0.9172187179608727 0.8915296979935915 1.001992518797754 0.8671178131686103 0.9179485021722081 0.9130149815387616 1.0 13.133305322177712 -5.788678963151277 24.969448718641207 0.925210635308259 0.942106231305796 0.017065837364169445 0.04177665873401959 867.2059291923081 794929.6870932842 0.0112919013343608 0.016753224177791126 1.6267508294653286e-06 5.788678963151277 0.016895595997536983 KEEENADS(ph)DDEGELQDLLSQDWR ddPTM_A459_Selumetinib_30min_R2 2 KEEENADSDDEGELQDLLSQDWR 23 1 J3QQQ3;Q96NB3 J3QQQ3 ZNF830 Zinc finger protein 830 1 KEEENADS(1)DDEGELQDLLSQDWR;KEEENADS(1)DDEGELQDLLSQDWR 104.3 1.2179e-05 6060000.0 44557.0 45865.0 43522.0 42217.0 49960.0 39049.0 36940.0 41513.0 34963.0 41086.0 True False 42080.70031580329 49382.69802078089 40721.841903170716 36466.97177161293 43683.57815193313 44427.64529847122 38657.78319522137 41633.7959571529 41956.576947842215 39899.74042575193 1.0546610044772053 1.2376696563396314 1.0206041810960802 0.9139651381811137 1.0948336426704934 1.1134820634020193 0.9688730498675379 1.043460321117322 1.0515501228865833 1.0 15.284091740340465 -5.293042174144522 24.623172270393333 1.026961403990651 1.1461653465074537 0.33180702342157276 0.06828258723028868 544.5878171394583 424312.3983494259 0.017806823834857606 0.037073608519958966 5.092814125636877e-06 5.293042174144522 0.11920394251680277 KEELTLEGIR ddPTM_A459_Selumetinib_30min_R1 1 KEELTLEGIR 10 1 P60842;P60842-2;J3KT12;J3QS69;J3KTB5;J3KSZ0;J3KTN0 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 101.39 0.022196 10691000.0 1684.7 2577.9 2311.6 2153.3 2074.7 2192.5 2156.3 1607.7 1111.6 1550.5 False True 1723.9502321444454 2276.078269566804 1997.6974167099004 1777.2665774470993 1887.0437513180348 2170.4454406307227 1993.6485549529098 1565.0585734544156 1886.3040119482337 1749.5217781489534 0.9853836938048502 1.3009716700840175 1.1418534148363242 1.0158585046752038 1.07860546515436 1.2405935540437336 1.1395391471275367 0.8945636419057867 1.078182641398154 1.0 10.77274490810349 -7.73608966761295 24.955446599460103 0.9897798578841894 1.1340884704072993 0.29449355320700565 0.09769277585143238 255.42573988529642 251453.34571618677 0.04583227518597533 0.026447995926922846 1.8361591973608725e-08 7.73608966761295 0.1443086125231099 KEEPSQNDIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 KEEPSQNDISPK 12 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KEEPS(0.048)QNDIS(0.952)PK;KEEPS(0.019)QNDIS(0.981)PK;KEEPS(0.001)QNDIS(0.999)PK 155.37 0.00076389 49471400.0 11724.0 17028.4 15620.2 18139.6 12210.1 14248.999999999998 13753.599999999999 12669.300000000001 8635.7 12350.800000000001 True False 11997.146389067175 15034.707011711615 13499.062635616878 14971.859382463857 11105.69861086824 14105.66799705685 12716.154878913108 12333.269008313764 14654.152173426917 13936.145486979758 0.8608654667300834 1.0788282187322327 0.9686367473867693 1.0743185335178758 0.7968988714450531 1.0121642322287374 0.9124585338746312 0.8849842318190831 1.05152118188763 1.0 13.766543969753329 KEEPSQNDIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 5 KEEPSQNDISPK 12 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KEEPS(0.08)QNDIS(0.92)PK;KEEPS(0.006)QNDIS(0.994)PK;KEEPSQNDIS(1)PK;KEEPSQNDIS(1)PK;KEEPSQNDIS(1)PK 165.89 0.00088499 72973600.0 121457.0 115535.0 114670.0 102425.0 96268.0 88022.0 111108.0 98404.0 72610.1 104233.0 True False 114706.90617089397 124396.16299642243 107292.257043256 88474.53830701963 84173.95319316053 100146.23151583984 116274.74215632534 98690.33934834087 87134.14889570443 101223.52246014205 1.1332040555698026 1.2289254510521987 1.0599537976511693 0.8740511706837462 0.8315651456044223 0.989357306304704 1.148692905861974 0.9749743631694041 0.8608092939071008 1.0 16.62718505886898 -5.503192370229465 4.913110148028576 0.9576027413411523 1.1761437724323975 0.5179633362188454 0.08759334030914559 0.1608642681211322 10.551704429107671 0.026007485020063278 0.05201946644814273 3.1391179172917434e-06 5.503192370229465 0.21854103109124523 KEEQAASAAAEDTCDVGVSS(ph)DDDKGAQAAR ddPTM_A459_Selumetinib_30min_R2 1 KEEQAASAAAEDTCDVGVSSDDDKGAQAAR 30 2 Q92539;J3KTK1 Q92539 LPIN2 Phosphatidate phosphatase LPIN2 1 KEEQAASAAAEDT(0.006)CDVGVS(0.248)S(0.746)DDDKGAQAAR 47.854 0.011375 4504600.0 10081.0 10088.0 10884.0 9938.5 8969.1 6756.1 8614.1 10262.0 5106.7 10438.0 True False 9520.738377440426 10861.717161967457 10183.735289603193 8584.859155131231 7842.321473228658 7686.691449230486 9014.672718515336 10291.86072103445 6128.182693119748 10136.627818819035 0.9392411902274653 1.0715316134821746 1.0046472526787165 0.8469147046311707 0.7736617752374305 0.7583085407318448 0.8893167313274788 1.0153140575929225 0.6045583208394555 1.0 13.307290166189652 -5.762968322564462 5.734596555152838 0.8368824291104994 1.013250464398813 0.29553981618043046 0.11585546091235226 0.18719965561613866 20.973485559973188 0.03142250011161905 0.050959231011190806 1.72596377918131e-06 5.762968322564462 0.17636803528831357 KEES(ph)DEEETASK ddPTM_A459_Selumetinib_30min_R1 5 KEESDEEETASK 12 1 Q9BY89;A0A1B0GVJ7;Q9BY89-2 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 KEES(0.862)DEEET(0.137)ASK;KEES(0.986)DEEET(0.009)AS(0.005)K;KEES(0.983)DEEET(0.016)ASK;KEES(0.994)DEEET(0.006)ASK;KEES(0.862)DEEET(0.138)ASK 176.43 0.00018594 84363000.0 36275.9 43019.700000000004 39892.9 38095.6 36035.0 42244.299999999996 38498.299999999996 39867.7 33656.7 40520.2 True False 37121.05788938607 37982.93352468408 34475.6632960142 31442.918602978545 32775.64061249597 41819.36069675547 35594.34223584084 38810.279087459516 57112.961711891054 45721.3623701717 0.8118974581038205 0.830748069516491 0.7540384080616522 0.6877073860662491 0.7168561677391873 0.9146569246597546 0.7785057222849148 0.848843452503486 1.2491526663070556 1.0 15.480580772065254 -8.128930060686207 5.21859674504857 1.119945071396374 0.7860726804698958 0.7285188637197949 0.0816152389184241 0.11159609370186757 4.155444934046833 0.05793331252755745 0.02097910028069083 7.4313880424150666e-09 8.128930060686207 -0.33387239092647814 KEES(ph)DEEETASK ddPTM_A459_Selumetinib_30min_R2 2 KEESDEEETASK 12 1 Q9BY89;A0A1B0GVJ7;Q9BY89-2 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 KEES(0.871)DEEET(0.076)AS(0.052)K;KEES(1)DEEETASK 140.77 0.0018805 44236000.0 331100.0 255390.0 239320.0 247450.0 245870.0 187382.0 313000.0 359610.0 211667.0 349910.0 True False 312698.78749831644 274977.5917917195 223922.41175191416 213746.88312494065 214981.61249431173 213192.16961556315 327555.1201977341 360656.4055633601 254006.31447012356 339807.18912463816 0.9202241668395703 0.8092165221697538 0.6589690239595887 0.6290240170479156 0.6326576346077789 0.627391580986729 0.963944056161772 1.061356019254421 0.7475012966160536 1.0 18.37435684963331 -7.27113034118711 24.53453932082129 0.948313368175754 0.707378001591076 0.4900245085348659 0.11496011483745396 479.4675663605828 1213858.7588819778 0.050186840189549733 0.03433010117753894 5.356358774513255e-08 7.27113034118711 -0.24093536658467796 KEESEES(ph)DDDMGFGLFD ddPTM_A459_Selumetinib_30min_R1 1 KEESEESDDDMGFGLFD 17 1 P05387;H0YDD8;P05386-2;P05386 P05387 RPLP2;RPLP1 60S acidic ribosomal protein P2;60S acidic ribosomal protein P1 1 KEES(0.001)EES(0.999)DDDMGFGLFD 96.143 0.0031374000000000003 4163200.0 3038.6 2525.4 3850.3 3901.6 3020.8 2816.9 2682.6 2929.1 1467.9 2679.6 True False 3109.393467913643 2229.724993973392 3327.4504081839996 3220.258802102633 2747.569173365557 2788.564543540562 2480.2493222263492 2851.410752942297 2490.9190888258477 3023.55276151431 1.02839067586052 0.7374519877260752 1.1005101186054667 1.065057915671961 0.9087220862616832 0.9222807615713453 0.8203095887052244 0.9430663123319212 0.8238384725849139 1.0 11.562029039147136 -6.49325024120953 23.9499029148648 0.8957146465727845 0.9753734060823509 0.12153493748266497 0.10382457372119759 947.8891204010682 766216.6860640398 0.032462400036139025 0.0367389347720634 3.211809355421782e-07 6.49325024120953 0.07965875950956636 KEESHSNDQS(ph)PQIR ddPTM_A459_Selumetinib_30min_R2 2 KEESHSNDQSPQIR 14 1 B5MBZ0;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 KEES(0.005)HS(0.001)NDQS(0.994)PQIR;KEESHSNDQS(1)PQIR 92.096 0.008286499999999999 5698900.0 12678.5 12669.3 12991.900000000001 11769.7 13065.2 12381.7 11163.5 14216.5 11445.599999999999 11528.4 True False 11973.879726056784 13640.994571779771 12156.015298511187 10166.646556135032 11423.832771630045 14087.166785118214 11682.624870055593 14257.867661331731 13735.039816784105 11195.5451376196 1.069521812369976 1.2184305814589502 1.0857903879699602 0.9080975004935461 1.0203909350732145 1.258283237837352 1.043506566803906 1.2735304521636936 1.2268308195758346 1.0 13.45063715769017 -6.7455218096379115 24.987733760243906 1.1702181609618978 1.0621673371821583 0.1729175038929287 0.1082483646570063 429.5309407079968 674285.6644632898 0.03698846259061795 0.03687553514695983 1.7967108496993916e-07 6.7455218096379115 -0.10805082377973951 KEGEPSMS(ph)LQS(ph)MK ddPTM_A459_Selumetinib_30min_R1 1 KEGEPSMSLQSMK 13 1 O43309 O43309 ZSCAN12 Zinc finger and SCAN domain-containing protein 12 2 KEGEPS(0.322)MS(0.698)LQS(0.98)MK 45.347 0.046256 3128600.0 141.07 121.87 192.07 129.52 0.0 70.37 0.0 0.0 0.0 0.0 True False 144.35665652556358 107.60140374417412 165.98794896498993 106.9017633915146 0.0 69.66214169084786 0.0 0.0 0.0 0.0 0.0 KEGITGPPADSSKPIGPDDAIDALS(ph)SDFTCGSPTAAGKK ddPTM_A459_Selumetinib_30min_R1 1 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 39 3 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 KEGITGPPADSSKPIGPDDAIDALS(0.369)S(0.369)DFT(0.121)CGS(0.121)PT(0.018)AAGKK 45.132 0.006439 23402000.0 2053.9 2401.3 3769.1 4041.0 2814.8 2743.5 2517.8 3063.0 2055.1 2156.0 True False 2101.751873806302 2120.1546796659172 3257.2769221843264 3335.315208964721 2560.201836993302 2715.9028808986955 2327.8803189075893 2981.7592899737997 3487.354601434701 2432.743601218411 0.8639430282556961 0.8715076585152922 1.3389314519429656 1.3710097551152811 1.0523927945842937 1.116395036262131 0.9568950536923405 1.2256775800295685 1.433506843749625 1.0 11.248368560243375 -5.241368430036788 23.345973504664702 1.1859569805906585 0.8677250857937379 0.41439336714596187 0.1517434124420858 356.01137369837096 414098.01143915363 0.04054150425676498 0.1068566907575711 5.736296219131774e-06 5.241368430036788 -0.3182318947969206 KEGITGPPADSSKPIGPDDAIDALSS(ph)DFTCGSPTAAGK ddPTM_A459_Selumetinib_30min_R1 1 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 38 2 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 KEGITGPPADSSKPIGPDDAIDALS(0.184)S(0.488)DFT(0.146)CGS(0.146)PT(0.036)AAGK 48.74100000000001 0.0031411 270480000.0 3987.8 4553.5 5349.5 6060.6 4836.5 4383.6 4630.8 4657.6 2391.9 3769.1 True False 4080.7079810919554 4020.3741031352815 4623.06728270013 5002.229981551986 4399.039428953427 4339.5049639903455 4281.495027721529 4534.065317983012 4058.8796025359657 4252.900699143002 0.9595117003118024 0.9453251762839003 1.0870386142878246 1.1761925178643322 1.0343621307311202 1.0203635755861393 1.0067234884144576 1.0661112588160517 0.9543791143192848 1.0 12.0542314545737 -10.19645661317514 14.853825584406026 0.9999999999589979 1.0319452791714283 0.011936848238909836 0.0667473946074069 0.0 0.0 0.06932708245727215 0.0168142872757199 6.361263518662743e-11 10.19645661317514 0.0319452792124304 KEGITGPPADSSKPIGPDDAIDALSSDFT(ph)CGSPTAAGKK ddPTM_A459_Selumetinib_30min_R1 1 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK 39 3 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 KEGITGPPADSSKPIGPDDAIDALS(0.1)S(0.1)DFT(0.382)CGS(0.337)PT(0.08)AAGKK 42.024 0.010838 22427000.0 951.82 1019.6 1305.1 1524.2 936.24 990.32 888.89 954.81 672.48 762.65 True False 973.9955540806827 900.2247580008197 1127.8745884011466 1258.027082777536 851.5572573065974 980.3582799386171 821.8403116505553 929.4853371400204 1141.1494440040922 860.5435563400844 1.1318376006708049 1.046111787565409 1.3106536910206248 1.4618982078350107 0.989557415232175 1.1392314458876527 0.9550246534247087 1.080114225819257 1.3260798196635537 1.0 9.749104405777018 KEGITGPPADSSKPIGPDDAIDALSSDFTCGS(ph)PTAAGK ddPTM_A459_Selumetinib_30min_R1 1 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 38 2 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 KEGITGPPADSSKPIGPDDAIDALS(0.019)S(0.033)DFT(0.086)CGS(0.612)PT(0.249)AAGK 72.116 2.9964e-06 255980000.0 4045.5 4764.7 5793.3 5595.7 4657.9 4130.1 4263.3 4654.9 2704.3 3773.1 True False 4139.752278827302 4206.846708951067 5006.601680319028 4618.516039298163 4236.593767419039 4088.5549438307603 3941.71584859748 4531.436930753849 4588.99958574272 4257.414138106299 0.9723630693509808 0.9881225017076387 1.1759724372376814 1.0848171893731913 0.9951096205321193 0.9603376160274961 0.9258474089510959 1.064363668592841 1.0778842360362693 1.0 12.055761719139635 -6.274529085309398 23.474738312111427 1.0010588106022538 1.059137180727647 0.12370837520387679 0.06644088255741983 755.4753592177925 1354846.340616378 0.022619104366365182 0.025835476231501182 5.314604056674469e-07 6.274529085309398 0.0580783701253933 KEGITGPPADSSKPIGPDDAIDALSSDFTCGS(ph)PTAAGK ddPTM_A459_Selumetinib_30min_R2 2 KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 38 2 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4 P20810-6 CAST Calpastatin 1 KEGITGPPADSSKPIGPDDAIDALS(0.128)S(0.112)DFT(0.074)CGS(0.517)PT(0.169)AAGK;KEGITGPPADSSKPIGPDDAIDALS(0.013)S(0.048)DFT(0.202)CGS(0.689)PT(0.048)AAGK 79.616 3.51e-07 81153000.0 265460.0 244460.0 268040.0 294840.0 261770.0 181855.0 207417.0 212701.0 153234.0 245463.0 True False 250706.79592057693 263209.29593720875 250794.59821988564 254682.28337263028 228884.11234650784 206903.87553467398 217062.30148898825 213319.92469545393 183885.0817156891 238375.84540053425 1.0517290269042294 1.1041777135386672 1.0520973624592065 1.068406419050961 0.9601816491176872 0.8679733266892916 0.9105884915657724 0.8948890116656754 0.7714081995460308 1.0 17.8628785295055 -6.436601540793076 2.45057663695329 0.883314930716026 1.0727262212991777 0.7084944117656065 0.054284341800367925 0.15212809103697078 1.7980908621497507 0.01803847162098928 0.02042594970440058 3.659303737226424e-07 6.436601540793076 0.18941129058315176 KEGSYSSLS(ph)PPTLTPVMPVNAGGK ddPTM_A459_Selumetinib_30min_R1 1 KEGSYSSLSPPTLTPVMPVNAGGK 24 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 KEGSYSSLS(1)PPTLTPVMPVNAGGK 166.78 5.161e-16 20040000.0 1545.3 1357.2 1578.1 1675.4 1220.3 924.82 1443.1 1156.0 857.91 955.98 True False 1581.3024833696268 1198.2983930548376 1363.8026878828055 1382.8228411530533 1109.9240804614628 915.5171504693755 1334.2458051535252 1125.339124782798 1455.8106107327362 1078.689345033755 1.465947995731935 1.11088368358486 1.2643146000854661 1.2819472515599764 1.0289561916704855 0.8487310593030161 1.23691386338091 1.0432467234091232 1.3496106339005138 1.0 10.075063723251281 -1.52287874622663 0.7320884028594778 1.1070982604374096 50.616951764863835 0.3039599068667581 0.14850271568993562 459.6120638766699 2.140044653535836 0.0573104778751773 37435.13988910557 0.029999999934632433 1.52287874622663 49.509853504426424 KEGSYSSLS(ph)PPTLTPVMPVNAGGK ddPTM_A459_Selumetinib_30min_R2 1 KEGSYSSLSPPTLTPVMPVNAGGK 24 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 KEGS(0.002)YS(0.005)S(0.056)LS(0.661)PPT(0.1)LT(0.175)PVMPVNAGGK 116.1 7.4242e-06 0.0 25452.0 25258.0 21646.0 28289.0 29938.0 20260.0 22191.0 23322.0 17636.0 23949.0 True False 24037.479732428706 27195.20738272938 20253.31992638283 24435.98939875305 26176.920790884207 23050.631098031365 23222.9254706323 23389.863158835058 21163.69279101179 23257.530143025186 1.0335353575640716 1.169307627056224 0.8708284930442923 1.050670008744728 1.1255245346305411 0.9911039975559972 0.9985121088877418 1.005689899787126 0.9099716376099666 1.0 14.505410276033665 -7.385141121162728 1.5436409772511746 0.9666413245797406 1.0450167995290827 0.15194132908947466 0.07738347549857326 0.8187397013553629 3.778487101745401 0.04866681364136343 0.026230080803006626 4.1196363244704186e-08 7.385141121162728 0.07837547494934205 KEGTGSTATSSSS(ph)TAGAAGK ddPTM_A459_Selumetinib_30min_R2 1 KEGTGSTATSSSSTAGAAGK 20 1 E5RGU4;A0A087WZK9;B3KS98;O15372;E5RHC7;E5RH59;E5RFW7;E5RFH0 E5RGU4 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 KEGTGSTATSSS(0.142)S(0.429)T(0.429)AGAAGK 148.09 1.0206e-05 2549500.0 15365.0 18390.0 21173.0 19531.0 15018.0 15541.0 13789.0 15400.0 12182.0 13767.0 True False 14511.074810968381 19800.45386683004 19810.75223141938 16870.844107145753 13131.30457737654 17681.63168284825 14430.215822385155 15444.81145039275 14618.740393519256 13369.510939038291 1.085385611869824 1.4810155702116017 1.4817858575195142 1.2618893977552872 0.9821828664677479 1.3225339179175795 1.0793375979258641 1.1552263594994105 1.0934386800068563 1.0 13.706659071702562 -6.0056263725837935 23.8280975818192 1.1226967278310003 1.3641043801411035 0.3983805122138512 0.13554669584128934 135.0483225956751 571950.2045421649 0.03752236954582446 0.05367035964919746 9.871283557621343e-07 6.0056263725837935 0.2414076523101032 KEHY(ph)LS(ph)GVNESGS(ph)VFGVIVS(ph)YS(ph)NLDDK ddPTM_A459_Selumetinib_30min_R1 1 KEHYLSGVNESGSVFGVIVSYSNLDDK 27 1 Q9HCM2-2;Q9HCM2-3;Q9HCM2 Q9HCM2-2 PLXNA4 Plexin-A4 5 KEHY(0.818)LS(0.958)GVNES(0.26)GS(0.959)VFGVIVS(0.677)Y(0.651)S(0.677)NLDDK 41.76300000000001 0.020536 4105900.0 419.38 606.94 581.63 682.32 448.83 529.6 705.54 671.72 213.55 507.76 True False 429.15073802857336 535.8791826412488 502.6478406648985 563.165620732692 408.2334057473726 524.2727048383265 652.3205497664869 653.9038035459351 362.37875292510364 572.9359420012339 0.7490379055808112 0.9353212870001699 0.877319441522864 0.9829469220687836 0.7125288811894671 0.9150633891235216 1.138557562801815 1.14132096733517 0.6324943616896062 1.0 9.162230034998924 -7.006507524068386 24.674792571623097 0.9951471927750719 0.8597321623686982 0.13011153106579276 0.15119552303789088 495.45271076647066 1878628.832811051 0.05386182388474164 0.045823347729990534 9.851275755103815e-08 7.006507524068386 -0.1354150304063737 KEKPELSEPSHLNGPS(ph)SDPEAAFLSR ddPTM_A459_Selumetinib_30min_R2 1 KEKPELSEPSHLNGPSSDPEAAFLSR 26 2 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 KEKPELSEPSHLNGPS(0.495)S(0.495)DPEAAFLS(0.01)R 70.461 0.00031748 3215100.0 41291.0 39333.0 38612.0 47970.0 47515.0 31217.0 23680.0 23506.0 23286.0 43254.0 True False 38996.21152096944 42349.71462447127 36127.74595756694 41436.40324713436 41545.74091051047 35516.85839028852 24781.16692102984 23574.398568372206 27943.85066520189 42005.14463261147 0.928367509790551 1.0082030426242667 0.8600790753977907 0.9864601969484578 0.9890631558081975 0.8455359147297009 0.589955519443457 0.5612264586769161 0.665248290646455 1.0 15.358278414141312 -7.051053430734702 4.187449473765587 0.669339972680631 0.9523155844387234 0.48390959399524536 0.11944887652273178 0.1635170644769361 5.973684639663163 0.044430890955143305 0.035078548767201984 8.890917272289316e-08 7.051053430734702 0.2829756117580925 KEKPELSEPSHLNGPSS(ph)DPEAAFLSR ddPTM_A459_Selumetinib_30min_R1 2 KEKPELSEPSHLNGPSSDPEAAFLSR 26 2 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 KEKPELS(0.001)EPS(0.004)HLNGPS(0.281)S(0.713)DPEAAFLS(0.001)R;KEKPELSEPSHLNGPS(0.37)S(0.63)DPEAAFLSR 126.37 2.8143e-09 101473000.0 5400.3 5648.4 7887.8 8579.2 8170.0 6219.299999999999 6275.9 5279.3 2096.6 3763.1000000000004 True False 5526.116482845405 4987.082702130077 6816.680084583993 7081.003771529355 7431.024942530658 6156.73948867259 5802.503810243923 5139.275814416809 3557.777070394625 4246.130540698052 1.3014476191626758 1.1745005610002313 1.6053863674816156 1.6676368528145293 1.7500698274125643 1.4499647219184266 1.3665391948336114 1.2103433385191984 0.8378868799002436 1.0 12.051933010008703 -7.90216818865756 1.8939589006669149 0.9200375041826082 1.4971268514648455 0.6438741023388354 0.16581023553771687 0.2483143302411839 1.665933050180789 0.15046246905355024 0.05403380820960182 1.2526559665521313e-08 7.90216818865756 0.5770893472822373 KELEEVS(ph)PETPVVPATTQR ddPTM_A459_Selumetinib_30min_R1 1 KELEEVSPETPVVPATTQR 19 1 Q15149 Q15149 PLEC Plectin 1 KELEEVS(0.995)PET(0.005)PVVPATTQR 98.067 0.00076361 11753000.0 3988.2 4663.5 4377.1 4151.7 4223.9 3481.4 4543.1 4073.9 2257.8 4413.8 True False 4081.11730031369 4117.495251997671 3782.7138616892676 3426.683532061079 3841.848990790112 3446.3802768582877 4200.410309329209 3965.846938107825 3831.3216968124516 4980.354224052791 0.8194431794838597 0.8267474695097162 0.759527072074617 0.6880401228313828 0.7714007514236177 0.691995011160828 0.8433958952243162 0.7962981666955798 0.7692869873208922 1.0 12.282032641234624 -10.224288522283066 0.592868644974911 1.0393098648869787 0.7677772114560277 0.6527919172600145 0.04946665937040922 10.25712407596235 2.521072823549309 0.8521076807413913 0.021492687725085755 5.966387796415337e-11 10.224288522283066 -0.271532653430951 KELEEVS(ph)PETPVVPATTQR ddPTM_A459_Selumetinib_30min_R2 3 KELEEVSPETPVVPATTQR 19 1 Q15149 Q15149 PLEC Plectin 1 KELEEVS(0.986)PET(0.014)PVVPATTQR;KELEEVS(0.999)PET(0.001)PVVPATTQR;KELEEVS(0.887)PET(0.113)PVVPATTQR 107.85 0.0016726 14531500.0 81009.0 64187.0 77142.0 85509.0 82173.0 69521.0 82332.0 87963.0 70318.0 69876.0 True False 76506.84408472084 69109.93650626544 72178.767705859 73862.52668874747 71849.69310405936 79096.88670119636 86160.60113776293 88218.9577669414 84383.56484907941 67858.4983203485 1.127446760220731 1.0184418785692708 1.0636658560452552 1.0884786506776936 1.0588164324661165 1.1656150468846707 1.2697098118943526 1.3000428826242898 1.2435224317920928 1.0 16.050241883725107 -6.924922394497455 3.611519582207249 1.2278442928305309 1.0690430231495116 0.3603514474867542 0.0811706216141003 0.20743798102750158 5.398198056940809 0.028949761884398646 0.024885058667251436 1.1887146237666901e-07 6.924922394497455 -0.15880126968101926 KELEEVSPET(ph)PVVPATTQR ddPTM_A459_Selumetinib_30min_R1 1 KELEEVSPETPVVPATTQR 19 1 Q15149 Q15149 PLEC Plectin 1 KELEEVS(0.363)PET(0.637)PVVPATTQR 89.39200000000002 0.0036491 14887000.0 4726.3 5729.8 5673.6 4754.1 5180.6 3879.3 5159.4 5456.8 2604.7 5463.4 True False 4836.413594221104 5058.95235228825 4903.156282853994 3923.8856805095693 4712.015644709217 3840.2777641225803 4770.222304143226 5312.067937815551 4419.985660238902 6164.68060802257 0.7845359559953697 0.820634948338548 0.7953625815542077 0.6365107829598045 0.7643568165684222 0.6229483745070156 0.7737987752253331 0.8616939425706096 0.7169853462459737 1.0 12.589810435225584 -10.955381308007055 3.2489835489247056 1.0035098190938063 0.7531114351110159 0.5159558532968351 0.07177736411064271 24039629.971733365 33155503.63405796 788237.0903274547 0.018496165102083517 1.1082013936740106e-11 10.955381308007055 -0.25039838398279046 KELQAEATVSGS(ph)PEAPGTNVVSEPR ddPTM_A459_Selumetinib_30min_R1 1 KELQAEATVSGSPEAPGTNVVSEPR 25 1 K7EJ02;Q9BZV1-2;Q9BZV1 K7EJ02 UBXN6 UBX domain-containing protein 6 1 KELQAEATVS(0.008)GS(0.991)PEAPGT(0.001)NVVSEPR 95.141 4.0907e-06 19538000.0 960.08 1257.9 1476.7 1283.1 1334.7 1075.8 1194.1 1159.0 648.28 1003.1 True False 982.4479960095204 1110.6244832181553 1276.1722509324757 1059.0306717700157 1213.9766206604243 1064.9784287482462 1104.028075624574 1128.2595550374253 1100.08381150216 1131.8576560214224 0.8679960689252305 0.9812404212753187 1.1275024241284293 0.9356571174264087 1.0725523781211652 0.9409119804797165 0.9754124732480304 0.996821065824969 0.9719277027899866 1.0 10.144476818923255 -4.784644871572229 4.777880332168215 1.0025997318840347 0.8610303643931843 0.3440052262320761 0.055314676221017475 0.18500245815690913 9.796665630081936 0.013362749520177845 0.0838448915272632 1.641931854124184e-05 4.784644871572229 -0.14156936749085047 KELQAEATVSGS(ph)PEAPGTNVVSEPR ddPTM_A459_Selumetinib_30min_R2 2 KELQAEATVSGSPEAPGTNVVSEPR 25 1 K7EJ02;Q9BZV1-2;Q9BZV1 K7EJ02 UBXN6 UBX domain-containing protein 6 1 KELQAEATVS(0.004)GS(0.996)PEAPGTNVVSEPR;KELQAEATVS(0.012)GS(0.988)PEAPGTNVVSEPR 148.6 3.8495e-10 19067800.0 131267.0 123192.0 145486.0 146783.0 158390.0 110147.0 110340.0 116332.0 99596.0 133610.0 True False 123971.70564343539 132640.43027528698 136125.58915318004 126790.90218520151 138491.63217543418 125318.74943508675 115471.0286345622 116670.5068602006 119517.98294474997 129752.33213952967 0.9554487661163726 1.0222585450922885 1.0491186316928536 0.9771762872736378 1.0673537029492979 0.9658304199135685 0.8899341285857582 0.8991784959575025 0.9211239672842708 1.0 16.98540094393247 -6.996840551313519 8.08405307335992 0.9202781260181437 1.0148913585234351 0.4988432873095642 0.04081432254846237 0.08760279249975034 51.428960585796126 0.01416983149761926 0.012030639989544024 1.0073014258150934e-07 6.996840551313519 0.09461323250529141 KELS(ph)PAGSISK ddPTM_A459_Selumetinib_30min_R1 1 KELSPAGSISK 11 1 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 KELS(0.928)PAGS(0.049)IS(0.023)K 72.428 0.031111 76062000.0 7913.5 8562.4 9345.7 9952.8 8862.6 7484.6 8563.6 8388.2 4493.4 7975.9 True False 8097.869153009482 7559.910227448236 8076.605272255462 8214.730317194771 8060.979394819118 7409.311719473066 7917.64075740609 8165.71768728639 7624.9716150487575 8999.684456845049 0.8997947863439082 0.8400194766493465 0.8974320500884335 0.9127798154019443 0.8956957806101787 0.82328572240526 0.8797687069332781 0.9073337766943202 0.8472487731777416 1.0 13.135658703823808 -11.652639821023568 2.1353362161076954 1.2300725109460817 0.878423289310423 0.6078221703490125 0.029361997715308525 4528106.695209415 1067092.8392042855 5049308.783709173 0.007435588038320304 2.2251545413904233e-12 11.652639821023568 -0.3516492216356587 KELS(ph)PAGSISK ddPTM_A459_Selumetinib_30min_R2 3 KELSPAGSISK 11 1 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 KELS(0.999)PAGS(0.001)ISK;KELS(0.999)PAGS(0.001)ISK;KELS(0.991)PAGS(0.009)ISK 125.47 0.006005 208104000.0 1230040.0 1053000.0 1172580.0 1209390.0 1262550.0 866720.0 1002510.0 1088660.0 844800.0 1056400.0 True False 1161679.301040257 1133761.7140713441 1097137.479408574 1044668.9956858829 1103937.1816597916 986102.8126991978 1049128.701435879 1091827.8203626361 1013783.6056842098 1025898.98714317 1.132352517741728 1.1051397148061726 1.0694400649169005 1.0182961566177016 1.0760681075764928 0.9612084864663012 1.0226432763691453 1.064264449079006 0.9881904733206747 1.0 19.96845725551095 -5.187507592738038 0.8703923884696914 1.016016020508549 1.1638098384037834 0.6310475856830721 0.03135800748024454 0.9188779484066915 0.81459339756732 0.011894898061331786 0.11538381241708102 6.493702785848181e-06 5.187507592738038 0.1477938178952345 KELSDIAHR ddPTM_A459_Selumetinib_30min_R2 1 KELSDIAHR 9 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 73.721 0.042921 8142200.0 100880.0 106650.0 116420.0 125850.0 133790.0 95699.0 92468.0 92079.0 84752.0 121920.0 False True 95273.49345463654 114829.71206620063 108929.66394851201 108709.01289664076 116982.10410222446 108880.66858097239 96767.94522186593 92346.93464550088 101704.76816873591 118399.85281379707 0.8046757761132485 0.9698467467420668 0.9200151973146583 0.9181515881409352 0.9880257561316208 0.9196013845743952 0.8172978506489292 0.7799581878765625 0.8589940422365484 1.0 16.853307761949814 -7.2150117974765795 8.918137871427684 0.8457642999500173 0.9254184406431887 0.10795802795026133 0.0704915853340338 0.6281449973706278 116.16025604611507 0.02594210623784249 0.020020540428760367 6.095203395819455e-08 7.2150117974765795 0.07965414069317134 KEMQPTHPIR ddPTM_A459_Selumetinib_30min_R1 2 KEMQPTHPIR 10 1 E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P27348;P31946-2;P31946;P63104-2 E7EX29;P27348;P31946-2;P63104-2 YWHAZ;YWHAQ;YWHAB 14-3-3 protein zeta/delta;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ; 83.883 0.02089 34533000.0 18361.4 23688.0 20246.7 23314.0 19466.0 17817.7 18000.0 14811.5 9546.4 14758.0 False True 18789.184894935013 20914.59794774756 17497.30934716228 19242.64755798156 17705.30373700143 17638.47011517721 16642.245508116855 14418.650905467492 16199.543558530604 16652.333055093364 1.1283214689960852 1.2559560200094915 1.0507422166775886 1.1555526480474705 1.063232622025056 1.059219153065295 0.9993942262058335 0.8658637115750776 0.9728092457036062 1.0 14.023436698060133 -6.812861556496765 0.917205595554901 0.9381401405119479 1.161870226009567 0.6615415404224064 0.05950551530203251 0.32199282705592963 0.5823174951678052 0.03648132667899204 0.03194293256109204 1.5386450482425518e-07 6.812861556496765 0.22373008549761908 KEMQPTHPIR ddPTM_A459_Selumetinib_30min_R2 1 KEMQPTHPIR 10 1 E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P27348;P31946-2;P31946;P63104-2 E7EX29;P27348;P31946-2;P63104-2 YWHAZ;YWHAQ;YWHAB 14-3-3 protein zeta/delta;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 90.05 0.020231 1848000.0 36915.0 37438.0 38293.0 38407.0 41004.0 33125.0 27700.0 30209.0 24821.0 39651.0 False True 34863.41208245346 40309.374217856646 35829.27007026598 33175.900344229514 35852.71093958903 37687.668071189 28988.104886508692 30296.903188630822 29785.893556685376 38506.172604329695 0.9053980108771799 1.0468288975914526 0.9304812098161446 0.861573563416146 0.9310899659645138 0.9787435499873944 0.7528170920640714 0.7868064037406873 0.7735355539682021 1.0 15.232802110340353 -7.2557628213648435 24.985230730780795 0.8105236284617284 0.942378148679882 0.32737546595372813 0.07846033674473968 472.2114039977566 2078431.5143029792 0.029827631657765096 0.022445361260364182 5.549286900890644e-08 7.2557628213648435 0.13185452021815358 KENESLTHSTDR ddPTM_A459_Selumetinib_30min_R1 1 KENESLTHSTDR 12 1 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7;H0YA05 Q8WX93 PALLD Palladin 0 82.20200000000001 0.024822 1351200.0 1953.5 2357.4 2091.1 2621.9 3885.9 2858.3 2979.9 2599.0 636.72 1175.5 False True 1999.012749150694 2081.3945120744734 1807.140105590099 2164.0343841585236 3534.421031111366 2829.5480971287534 2755.1237438687444 2530.0660772582114 1080.4673358111545 1326.3868753396305 1.507111376263304 1.5692212813411004 1.3624532473810618 1.6315257821021545 2.664698435142728 2.13327510226172 2.0771645099121447 1.907487268079587 0.814594411253122 1.0 10.373285921143891 -6.0093413864540475 24.82336143957312 1.872991354249185 1.489963071601511 0.03537964011546013 0.5140600212012991 1011.691205655582 2688434.7134783203 0.15024970708744353 0.20979069107679846 9.787203389218845e-07 6.0093413864540475 -0.38302828264767386 KENPS(ph)PLFSIK ddPTM_A459_Selumetinib_30min_R1 1 KENPSPLFSIK 11 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 KENPS(1)PLFSIK 75.574 0.027218 19893000.0 4959.9 5702.3 5080.6 5275.7 4278.7 5119.9 4800.6 4127.3 3090.0 4314.4 True False 5075.456019714626 5034.672065072648 4390.682425738159 4354.398032154212 3891.6923404658396 5068.398454497255 4438.486877014765 4017.8305966401767 5243.504315329292 4868.1952658147975 1.042574453690312 1.034196820416567 0.901911732376512 0.8944583761320037 0.7994117178893565 1.041124724410361 0.9117314804898009 0.8253223992172192 1.0770940829243172 1.0 12.249171321114066 -5.252797435944508 21.635396424440042 0.9223290071893243 1.0383857886972543 0.20159526812403972 0.0836405504809498 142.08855913557363 355706.6567930418 0.020720384043968573 0.052577036098312914 5.587307377059474e-06 5.252797435944508 0.11605678150792997 KENPS(ph)PLFSIK ddPTM_A459_Selumetinib_30min_R2 2 KENPSPLFSIK 11 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 KENPS(0.998)PLFS(0.002)IK;KENPS(0.974)PLFS(0.026)IK 102.29 0.007405 34460000.0 330340.0 281430.0 318020.0 332670.0 325050.0 285660.0 287310.0 275260.0 260568.0 306680.0 True False 311981.025255795 303014.7760599229 297558.939433995 287359.7721122412 284214.3130161304 325007.07203670463 300670.48429396463 276060.961028254 312688.88087822334 297825.3515496671 1.047530116668954 1.0174243880960898 0.9991054753590121 0.9648600114699081 0.9542985898859359 1.0912673160481592 1.0095530240441035 0.9269223039336075 1.0499068640436995 1.0 18.184107038962217 -4.88842514348416 2.454928110427724 0.9978104629545608 1.0526047032021228 0.09944482797915744 0.04427610019003842 1.0263497511673108 9.34142885517703 0.01188194502849752 0.10929179519064257 1.2929295354586663e-05 4.88842514348416 0.054794240247562076 KENQWCEEK ddPTM_A459_Selumetinib_30min_R2 2 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 ; 103.31 0.020771 4838600.0 41929.0 38864.0 38209.0 40821.0 38463.0 31719.0 37177.0 31373.0 26965.0 38555.0 False True 39598.7540350858 41844.74383254392 35750.6745388137 35261.10937984723 33630.934076417245 36088.00433358621 38905.80416482795 31464.29023592026 32358.753465050606 37441.8169720797 1.057607702762249 1.117593835356534 0.9548327893775271 0.9417574314339867 0.8982185373507855 0.9638422291444074 1.0391003244805117 0.840351584950675 0.864241003292668 1.0 15.192362827104416 -5.336457230995312 5.025174872265651 0.9340298753615065 1.0873153929641555 0.5196599520810348 0.05769343893127612 0.16014624057128568 7.3693909505352 0.015883787737028553 0.03475283522480194 4.608321488705598e-06 5.336457230995312 0.15328551760264897 KENVATTDTLESTTVGTS(ph)V ddPTM_A459_Selumetinib_30min_R1 1 KENVATTDTLESTTVGTSV 19 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 KENVATTDTLESTTVGT(0.397)S(0.603)V 153.81 9.2028e-05 0.0 980.14 1239.9 1317.8 1591.5 1586.7 1244.0 1142.4 1240.5 656.08 911.67 True False 1002.9753549795549 1094.731931586129 1138.8499981572534 1313.5744011549996 1443.183265154638 1231.4864894616283 1056.2278482484833 1207.5979102881163 1113.3198418127001 1028.6917249178055 0.9750008974357159 1.0641982481910217 1.10708579700906 1.276936879471794 1.4029307616622961 1.1971385203473144 1.0267681003586162 1.173916228775541 1.0822677142675146 1.0 10.006594989376152 -9.75607768893132 10.895692521915626 0.9999834861477718 1.151991293480438 0.1149662684662639 0.11945415003455141 0.0 0.0 0.12770093787253514 0.030972026784641248 1.753566786330618e-10 9.75607768893132 0.15200780733266617 KEPAITSQNS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 2 KEPAITSQNSPEAR 14 1 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193;E5RIS7 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 KEPAITSQNS(1)PEAR;KEPAITSQNS(1)PEAR 201.75 9.8784e-05 29747000.0 7513.4 8088.2 8162.599999999999 8096.5 7785.1 7205.2 8442.9 7363.5 4531.4 7049.4 True False 7688.44760146856 7141.229783897828 7054.163753952342 6682.598265128145 7080.939079571041 7132.722229798163 7806.045255582209 7168.196059981087 7689.454839638562 7954.259156970804 0.9665824874125082 0.8977869142771809 0.8868410765533515 0.8401283052579165 0.8902072386421532 0.8967173546951035 0.9813667246108387 0.9011770824312606 0.9667091161971787 1.0 12.957511851882629 -7.204913815044681 8.90989948556066 0.9540369071825763 0.8930788140884249 0.41720778907078515 0.037553360494369914 0.4643919746096843 70.21267582256526 0.014623007401518982 0.01130500648757082 6.238586268163321e-08 7.204913815044681 -0.060958093094151344 KEPAITSQNS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 4 KEPAITSQNSPEAR 14 1 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193;E5RIS7 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 KEPAITSQNS(1)PEAR;KEPAIT(0.003)S(0.01)QNS(0.987)PEAR;KEPAITS(0.003)QNS(0.997)PEAR;KEPAITS(0.002)QNS(0.997)PEAR 122.16 0.0012981 97510000.0 121415.0 95589.0 113747.0 136082.0 128767.0 103947.0 123711.0 117138.5 101977.5 111132.0 True False 114667.24036275467 102920.36893292116 106428.64185836956 117547.39684545646 112590.13826841414 118264.7557130832 129463.80662869598 117479.35364167733 122375.84948941931 107923.33040438764 1.062487971165249 0.9536433739329537 0.9861504594009701 1.0891750319880562 1.0432418814962439 1.0958219624055925 1.1995905439870729 1.0885445547453305 1.1339146876850281 1.0 16.719647248626572 -6.153211316033119 1.3241470203261743 1.1119872853564057 0.997629341507632 0.32593509142866817 0.05704381383201752 0.44245069504580625 1.5707914919625647 0.02126661307053877 0.033452757707128626 7.027303069859305e-07 6.153211316033119 -0.11435794384877362 KEPAVLELEGK ddPTM_A459_Selumetinib_30min_R2 1 KEPAVLELEGK 11 1 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 0 92.295 0.036769 0.0 29191.0 30391.0 29635.0 30068.0 32333.0 26113.0 25209.0 27275.0 21620.0 27389.0 False True 27568.681080831604 32721.891977533003 27728.316364148348 25972.686529806884 28271.039479312538 29709.828719787405 26381.268450685864 27354.365734380677 25944.604113272562 26598.208404831807 1.0364863926633308 1.230229174818736 1.0424881233395873 0.9764825560615094 1.062892622278155 1.1169860867166657 0.9918438132808023 1.0284288820525036 0.9754267550050284 1.0 14.699041451873166 -5.195805521949272 0.3117108602929766 0.9911040354748913 1.1954513418164951 0.2314946156567267 0.06474026278529245 8.47726326856198 0.819569158953368 0.07551932365972402 0.6456362240070982 6.370807432385035e-06 5.195805521949272 0.2043473063416038 KEPVVGGTLS(ph)PLALANK ddPTM_A459_Selumetinib_30min_R1 1 KEPVVGGTLSPLALANK 17 1 J3KTM2;O15534-4;O15534;J3KRL7 J3KTM2 PER1 Period circadian protein homolog 1 1 KEPVVGGT(0.001)LS(0.999)PLALANK 92.792 0.0039481 8544800.0 3276.4 3293.3 3477.0 3847.8 3614.0 3136.3 3851.5 3149.6 2089.0 2814.5 True False 3352.7337452353895 2907.7189049863655 3004.8424977938766 3175.853962151559 3287.1143381035226 3104.7516695325567 3560.9782541395593 3066.062376657355 3544.880425476664 3175.768490551585 1.0557236005112791 0.9155953633387606 0.9461780689410326 1.0000269136746676 1.0350610719525712 0.9776379099325677 1.1212965506566472 0.9654552546192763 1.1162275953122043 1.0 11.632890030358686 -6.071720405139841 2.9874292074524442 1.035862150163478 0.9670115148493137 0.18936777110201541 0.05869306729091375 0.3985400109359551 6.966212074264183 0.01709673651351781 0.02406961055936864 8.477730270999104e-07 6.071720405139841 -0.06885063531416424 KEQES(ph)DEEEEEEEEDEPSGATTR ddPTM_A459_Selumetinib_30min_R1 2 KEQESDEEEEEEEEDEPSGATTR 23 1 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 KEQES(1)DEEEEEEEEDEPSGATTR;KEQES(1)DEEEEEEEEDEPSGATTR 133.21 3.4073e-06 10871000.0 1834.6599999999999 2455.45 1598.3200000000002 1370.19 1579.85 1340.06 2385.14 2342.85 1269.23 2416.02 True False 1877.4040083730797 2167.9647724922643 1381.2769229433163 1130.912038151786 1436.952846445172 1326.5802130771292 2205.2269695127684 2280.710007350676 2153.790609108543 2726.139701027692 0.688667571828891 0.7952507979231555 0.506678701176835 0.4148400897156731 0.5271016910481418 0.48661490552998404 0.8089192819727649 0.8366078988875371 0.7900514446477609 1.0 11.412643779606258 -7.360946690397554 5.155237633760335 0.8522118847749757 0.5687429458085816 0.6108782626392795 0.11329101028247504 0.1841587678973576 7.565307565917903 0.05392242302238023 0.03580228463357763 4.3556533600390946e-08 7.360946690397554 -0.283468938966394 KEQSEVSVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 KEQSEVSVSPR 11 1 Q7L4I2;E9PI52 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 KEQSEVS(0.025)VS(0.975)PR;KEQSEVSVS(1)PR 184.96 3.9856e-05 59345000.0 2426.96 3270.7999999999997 3324.06 3326.7 3307.56 2670.9 2875.2 2627.44 1569.22 2100.8599999999997 True False 2483.503445957905 2887.8532154463337 2872.670909754592 2745.754294893078 3008.3917819971466 2644.0331709831685 2658.321349163201 2557.7517560720717 2662.8517287058357 2370.5258451093277 1.0476592993413945 1.218233170249678 1.2118285551204802 1.1582891199258134 1.269082042789709 1.1153783353335371 1.1214057651586584 1.078980750768448 1.1233168936755575 1.0 11.210991407069486 -8.23114771949628 0.6461772918787634 1.0086659919505498 1.1806980180019704 0.41299420440625545 0.05986142777296985 0.6765654827355356 0.6491334996685313 0.05853232245966132 0.02632411756075842 5.872895598145462e-09 8.23114771949628 0.17203202605142054 KEQSEVSVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 KEQSEVSVSPR 11 1 Q7L4I2;E9PI52 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 KEQSEVS(0.001)VS(0.999)PR;KEQSEVS(0.003)VS(0.997)PR 111.88 0.014356 37883000.0 97001.0 96670.0 111973.0 113459.0 113959.0 88725.0 90400.0 101517.0 78213.0 97334.0 True False 91610.07274576918 104084.27815695819 104768.77908698466 98005.68847230785 99642.45161361377 100946.06338464124 94603.77912420162 101812.39766295586 93857.78545381081 94523.71451589683 0.9691755472682188 1.1011446036587302 1.1083861824893142 1.036837041098564 1.054152940602605 1.0679443132512985 1.0008470319719749 1.0771095717554904 0.9929548995667745 1.0 16.528388703829123 -8.13280378012459 0.7356214343394574 0.9974758562020638 1.059742884648461 0.16848240195124398 0.04192510632311933 1.112738969759468 1.2842135827903913 0.03934182426921644 0.016561837946562248 7.3653980055679665e-09 8.13280378012459 0.06226702844639709 KES(ph)APQVLLPEEEK ddPTM_A459_Selumetinib_30min_R1 2 KESAPQVLLPEEEK 14 1 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5 B1ALK7 ARHGEF7 Rho guanine nucleotide exchange factor 7 1 KES(1)APQVLLPEEEK;KES(1)APQVLLPEEEK 91.926 0.008397799999999999 12263600.0 19601.7 20824.9 15313.6 13825.2 14831.5 16057.0 15978.400000000001 16450.1 11058.1 15914.099999999999 True False 20058.381471731325 18386.711026766658 13234.09723158364 11410.888351145511 13489.993443714007 15895.481158589515 14773.136423716356 16013.789910544558 18764.788048331022 17956.829751461002 1.1170335604534725 1.023939708804706 0.7369951942940757 0.6354623009229733 0.7512458284913257 0.8852053162277282 0.8227029285341632 0.8917938262037398 1.0449944844414578 1.0 14.132245046690782 -8.132321782388127 3.771423551443107 1.021773859136963 0.8447530689994549 0.20085911016160285 0.13187043234023785 0.4196344265105131 10.107046550269724 0.11381320186571307 0.03849691588245895 7.373576962634282e-09 8.132321782388127 -0.17702079013750804 KES(ph)APQVLLPEEEK ddPTM_A459_Selumetinib_30min_R2 2 KESAPQVLLPEEEK 14 1 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5 B1ALK7 ARHGEF7 Rho guanine nucleotide exchange factor 7 1 KES(1)APQVLLPEEEK;KES(1)APQVLLPEEEK 99.092 0.0051005 11535300.0 208075.0 191668.0 183312.0 192506.0 188218.0 195360.0 222057.0 205262.0 162916.0 196291.0 True False 196511.0244902208 206368.31929024408 171517.90549501465 166286.35070862746 164572.3721497308 222269.0666984899 232383.09049759796 205859.27843704683 195503.75225337196 190623.5688047331 1.0308852453156963 1.0825960325065536 0.8997728170261595 0.8723283891456481 0.8633369587068844 1.1660104156699171 1.219067988049482 1.0799256342111638 1.0256011545646693 1.0 17.540366980335094 -6.768323155300998 24.99996098005428 1.1106755827982058 0.9500808616835827 0.4181963828661194 0.08685256390730046 167.34931875848238 607762.3477385669 0.033278201734784664 0.029990009159477995 1.7048133779480493e-07 6.768323155300998 -0.16059472111462303 KES(ph)KEETPEVTK ddPTM_A459_Selumetinib_30min_R1 1 KESKEETPEVTK 12 2 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KES(0.998)KEET(0.002)PEVTK 65.563 0.030503 37392000.0 6372.7 6953.9 8128.2 9408.5 5243.9 6033.8 6287.8 6044.7 3975.0 4935.2 True False 6521.171510884374 6139.734155219596 7024.435085006665 7765.4820944183475 4769.590170885737 5973.105450252067 5813.506183663177 5884.374920047215 6745.284677486714 5568.680992918876 1.1710441878744147 1.1025472931609603 1.2614181156972222 1.3944921794394256 0.8565026757594373 1.07262482046421 1.0439646643533038 1.0566909700034488 1.2112894752031953 1.0 12.44311993353403 -6.2577641695889765 24.999301761885548 1.0448249161992194 1.225176470792387 0.4364254010994866 0.1067936748916782 347.98653928569377 2367050.677374895 0.033155759293031696 0.04118087712390965 5.523773095552231e-07 6.2577641695889765 0.18035155459316754 KES(ph)KEETPEVTK ddPTM_A459_Selumetinib_30min_R2 2 KESKEETPEVTK 12 2 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KES(0.999)KEET(0.001)PEVTK;KES(0.983)KEET(0.017)PEVTK 67.456 0.028271 43293400.0 207859.0 169225.0 161522.0 163186.0 121448.0 112299.0 153072.0 128799.0 87723.0 132529.0 True False 196307.02890550465 182204.01335586302 151129.85037185668 140959.78528844813 106190.61648110453 127767.16790117604 160190.1513064136 129173.78376617766 105270.05118541194 128702.54341830492 1.5252769967993078 1.415698621927535 1.1742569055582626 1.0952369824604407 0.8250856095047567 0.9927322685917034 1.244654123001817 1.0036614688051744 0.8179329513579741 1.0 16.973681038801317 -5.3400484839951785 1.5392194598506304 0.9950814995858881 1.542115590604289 0.7391958590777412 0.11327893864388944 0.2689789938893152 1.0937975540921923 0.03662617150129304 0.16007839824545217 4.570371638120743e-06 5.3400484839951785 0.5470340910184008 KES(ph)PS(ph)ST(ph)GS(ph)S(ph)TWK ddPTM_A459_Selumetinib_30min_R1 1 KESPSSTGSSTWK 13 1 Q6NV74;C9JFM2;C9JXD6;C9JK00 Q6NV74 KIAA1211L Uncharacterized protein KIAA1211-like 5 KES(0.945)PS(0.528)S(0.528)T(0.959)GS(0.738)S(0.738)T(0.564)WK 61.65 0.023882 4415700.0 716.37 1029.5 975.62 966.77 740.73 828.63 802.91 658.85 492.2 702.1 True False 733.0600271866301 908.9656613984346 843.1361626970556 797.9417680204955 673.7311022865028 820.2947345358425 742.3458522734503 641.3751577535871 835.2274511343294 792.221374033138 0.9253222031295091 1.1473632133540659 1.064268385495224 1.0072207014034922 0.8504328769326049 1.0354362573680451 0.9370434535163129 0.8095908274834793 1.0542854289354133 1.0 9.62975981527329 -6.015071077023959 10.712903003863032 0.9408987535450177 1.05253655728176 0.20300942586220594 0.0872014418166588 0.617383709615274 433.1382658945267 0.02443947731572293 0.03319094018763851 9.658927871746257e-07 6.015071077023959 0.11163780373674226 KES(ph)PSS(ph)T(ph)GS(ph)ST(ph)WK ddPTM_A459_Selumetinib_30min_R1 1 KESPSSTGSSTWK 13 1 Q6NV74;C9JFM2;C9JXD6;C9JK00 Q6NV74 KIAA1211L Uncharacterized protein KIAA1211-like 5 KES(0.933)PS(0.572)S(0.634)T(0.714)GS(0.634)S(0.634)T(0.88)WK 44.691 0.036018 7101100.0 971.79 1325.7 1280.6 1387.9 896.1 950.72 942.6 863.42 732.1 1160.2 True False 994.4308162258268 1170.48642769879 1106.7015538322808 1145.5293191096598 815.0479132193044 941.1566199846933 871.4989231083861 840.5192968165779 1242.320229531578 1309.1229713050102 0.759616046790868 0.894099678452652 0.84537631535795 0.8750356874173014 0.6225907963457528 0.7189214769079283 0.6657120394424254 0.6420476267242482 0.9489713776034047 1.0 10.354384906589411 -4.460286004782965 15.520518841249139 0.7841663453130314 0.5298711768881638 0.0 0.1274467750629726 4052674.7863835734 24792601.398049716 0.032145922102821856 32455483.027722064 3.465085819497853e-05 4.460286004782965 -0.25429516842486766 KESPTS(ph)SSFGK ddPTM_A459_Selumetinib_30min_R1 1 KESPTSSSFGK 11 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 KES(0.173)PT(0.034)S(0.646)S(0.133)S(0.014)FGK 120.84 0.008286700000000001 8859100.0 1019.4 1315.4 1187.6 1295.7 1491.3 1077.1 1293.5 1059.0 749.23 1207.6 True False 1043.1500365928935 1161.3923564871313 1026.3304430198466 1069.430318301308 1356.4121783104001 1066.265351928552 1195.9302535971751 1030.9118798832042 1271.3885884058798 1362.6072230201087 0.7655544598397445 0.8523309849429678 0.7532107754023704 0.7848412222056201 0.9954535359823077 0.7825184938952996 0.8776779055570338 0.7565730332753348 0.9330558116284969 1.0 10.412154044117132 -14.522878713550694 0.13947561695471106 1.5838831114455263 0.7716012299886494 0.36576885828592354 0.07357573894100701 160.47409938200366 1.3685178623146164 25.94972276717753 0.4521461320788142 3.0000002191806175e-15 14.522878713550694 -0.8122818814568769 KESVS(ph)PEDSEK ddPTM_A459_Selumetinib_30min_R2 1 KESVSPEDSEK 11 1 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 KES(0.001)VS(0.905)PEDS(0.094)EK 136.14 0.0025863 10084000.0 29735.0 30503.0 27356.0 23209.0 21877.0 20161.0 21305.0 22599.0 16074.0 23308.0 True False 28082.447738636172 32842.482017396265 25595.944742960775 20047.89416224184 19128.615677138536 22937.99474666389 22295.72471505661 22664.759348534164 19289.24914508524 22635.03747854321 1.2406627453237844 1.4509577043346695 1.1308107957508065 0.8857018320047474 0.8450887565470756 1.01338443854612 0.9850094012961874 1.001313091264776 0.8521854299278454 1.0 14.466270074916455 -5.5158774456824515 3.997371583546051 0.9428535546742564 1.3417391160521206 0.8196254314594279 0.07612744783336528 0.07941858790286355 2.8934378047428155 0.020770740822986782 0.041936791209386155 3.048755201799353e-06 5.5158774456824515 0.39888556137786424 KESYS(ph)IYVYK ddPTM_A459_Selumetinib_30min_R1 2 KESYSIYVYK 10 1 Q16778;P33778;P23527;P06899;Q8N257;Q6DRA6;Q6DN03 Q16778 HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB;HIST2H2BD;HIST2H2BC Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B;Putative histone H2B type 2-D;Putative histone H2B type 2-C 1 KES(0.008)YS(0.992)IYVYK;KES(0.019)YS(0.981)IYVYK 132.79 0.0042749 24487000.0 3148.1000000000004 4658.8 4281.0 5371.2 4512.2 3878.3999999999996 3914.6 3433.8 2031.5 3547.7 True False 3221.4446048637337 4113.34553018264 3699.66371384975 4433.220749911234 4104.0723066936125 3839.3868173054457 3619.31857033746 3342.7244694456504 3447.307125110507 4003.0818525243762 0.8047411278468524 1.0275446972408846 0.9242038634600268 1.107451936591206 1.025228176162711 0.9591077471684215 0.9041330414103544 0.8350377515607633 0.8611632867153608 1.0 11.966895400018739 -7.235843613905498 3.2935934235533266 0.8841600988131002 0.9849825193080223 0.14917068652417909 0.08441891665286319 0.3867635433999287 8.706499191528863 0.03613670802870409 0.025492998458430935 5.80973583967692e-08 7.235843613905498 0.10082242049492207 KESYS(ph)VYVYK ddPTM_A459_Selumetinib_30min_R1 1 KESYSVYVYK 10 1 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 1 KES(0.052)YS(0.944)VYVY(0.004)K 108.72 0.018873 28241000.0 3423.5 5337.4 5005.9 5306.0 3990.7 4476.7 4709.1 4115.8 1889.8 2984.9 True False 3503.2608890286156 4712.494726710058 4326.126275440429 4379.4067059556555 3629.7418896153104 4431.66846251838 4353.888795681842 4006.6356139974428 3206.8525744690273 3368.040990388141 1.0401479373399465 1.3991797428115562 1.2844636653136088 1.3002830780426347 1.0777012215629271 1.3158000378159482 1.2927065935679392 1.189604172108282 0.952141789135251 1.0 11.717693981341288 -8.168297042775015 3.9232741475745665 0.975014365774047 1.2497565678265898 0.507281924477103 0.10381326271215009 0.17777484033374846 4.770114754493317 0.07848814835136264 0.02617966546642151 6.787392390777745e-09 8.168297042775015 0.27474220205254285 KESYSIYVYK ddPTM_A459_Selumetinib_30min_R1 2 KESYSIYVYK 10 1 Q16778;P33778;P23527;P06899;Q8N257;Q6DRA6;Q6DN03 Q16778 HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB;HIST2H2BD;HIST2H2BC Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B;Putative histone H2B type 2-D;Putative histone H2B type 2-C 0 ; 126.12 0.0047499 37934000.0 8419.400000000001 7412.3 10377.0 9256.0 8856.4 7861.299999999999 9035.9 9850.0 4666.0 8303.9 False True 8615.555638699441 6544.4644701152165 8967.860396780858 7639.61335663881 8055.340183724412 7782.2224594893 8354.314788155174 9588.7460026908 7917.861208843519 9369.7864518356 0.9195039484610239 0.6984646345737276 0.9571040325069519 0.8153455146400014 0.8597143835808894 0.8305656163556122 0.8916227526742097 1.0233686810239206 0.8450417999966648 1.0 13.193800452248945 -7.52800894604383 23.047646979465704 0.9520223577107029 0.8456212922561522 0.28599218405699645 0.07727938484039333 67.57154631430548 303549.2967673353 0.033589653171284865 0.01950424928865943 2.964770317511028e-08 7.52800894604383 -0.10640106545455064 KESYSVYVYK ddPTM_A459_Selumetinib_30min_R1 1 KESYSVYVYK 10 1 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 0 138.45 0.002213 43911000.0 9192.2 8704.2 11769.0 10853.0 11651.0 9420.5 10302.0 11523.0 6273.3 9003.5 False True 9406.360375092403 7685.108217527207 10170.834442489546 8957.727286041596 10597.169107151116 9325.73832312963 9524.91184581222 11217.372608020929 10645.3319162962 10159.18692651668 0.9258969682446426 0.756468826995216 1.0011465008033726 0.8817366341257947 1.0431119324609777 0.9179610918259953 0.9375663539521132 1.1041604696476506 1.0478527458246312 1.0 13.31049732260232 -5.980258158896899 0.48002571357774754 1.0409074889262326 0.8203523584743952 0.37161781725527354 0.07506019525387678 1.7353869678515614 0.6723545620792422 0.06055488980701743 0.19359166853830925 1.0465062854321828e-06 5.980258158896899 -0.2205551304518374 KESYSVYVYK ddPTM_A459_Selumetinib_30min_R2 2 KESYSVYVYK 10 1 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880 U3KQK0 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L 0 ; 119.74 0.007177600000000002 16022300.0 170421.0 113811.0 167920.0 168108.0 169976.0 133429.0 146832.0 171348.0 136746.0 132308.0 False True 160949.68306931606 122539.93773995647 157116.21001747204 145211.4003975248 148622.0952752801 151807.63360213343 153659.97894208817 171846.59431181158 164099.02100247776 128487.92426253209 1.252644433265625 0.9537078168496018 1.222809154395283 1.1301560145124812 1.15670088164557 1.181493393044108 1.1959098866608153 1.3374532688432819 1.277155203061601 1.0 16.971273250780435 -6.964331488928451 1.7215581700690987 1.2309593423041918 1.1334050066585943 0.03910061754098049 0.11063660566650163 0.7666401543059097 4.611911838924402 0.04928337447854188 0.03843723600842675 1.0855966914698174e-07 6.964331488928451 -0.09755433564559746 KET(ph)ES(ph)EAEDNLDDLEK ddPTM_A459_Selumetinib_30min_R1 3 KETESEAEDNLDDLEK 16 1 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KET(1)ES(1)EAEDNLDDLEK;KET(1)ES(1)EAEDNLDDLEK;KET(1)ES(1)EAEDNLDDLEK 93.5 0.014497 40149300.0 11295.9 13061.0 16091.399999999998 15923.1 9751.8 13032.2 11483.3 11657.7 8055.1 11825.3 True False 11559.072492004778 11531.81204810583 13906.27626373322 13142.429498605816 8869.751411820122 12901.107900290854 10617.105435742133 11348.499926453656 13668.916378773132 13343.192443176289 0.8662898733740507 0.8642468507604566 1.042200082398189 0.9849539047401551 0.6647398251650124 0.9668681580687598 0.7956945446868469 0.8505086001556758 1.0244112446840574 1.0 13.703816261283398 -8.266324265209255 24.687646629810207 1.0122056463707056 0.8808402954377254 0.2200128346000625 0.09996582252466688 584.7572257692983 2955231.367924275 0.0880288082202461 0.025573219225652078 5.41596357433057e-09 8.266324265209255 -0.1313653509329803 KET(ph)ESEAEDNLDDLEK ddPTM_A459_Selumetinib_30min_R1 1 KETESEAEDNLDDLEK 16 1 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KET(0.5)ES(0.5)EAEDNLDDLEK 88.95100000000002 0.016896 3233300.0 1115.4 1324.1 1436.3 1877.6 1212.7 1145.5 1075.2 1108.1 1036.9 1290.6 True False 1141.3866498094114 1169.0737564426097 1241.25834903116 1549.712406917138 1103.011499119575 1133.9773100307832 994.0967983515138 1078.7095883839263 1759.5435678203712 1456.2610815085714 0.7837788596444706 0.8027913203802314 0.8523597621281717 1.0641720956463099 0.7574270253634344 0.7786909397153375 0.6826363836639157 0.740739144979737 1.208261066757084 1.0 10.508053312747723 -8.257392108899182 24.998853181198637 1.1041305442670133 0.8108621337006883 0.5527104509347187 0.1065937943655259 253.63595891250262 1566663.4568784498 0.08285195849497734 0.02876247742621739 5.528507347315974e-09 8.257392108899182 -0.293268410566325 KET(ph)ESEAEDNLDDLEK ddPTM_A459_Selumetinib_30min_R2 2 KETESEAEDNLDDLEK 16 1 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KET(0.945)ES(0.055)EAEDNLDDLEK;KET(0.998)ES(0.002)EAEDNLDDLEK 156.72 0.00010189 16237900.0 96072.0 91108.0 92018.0 85309.0 83653.0 58253.0 84134.0 77229.0 54840.0 75778.0 True False 90732.70284668743 98095.6906416069 86097.66206162312 73689.76703376677 73143.76227269138 66276.82198191612 88046.39770835816 77453.72360405071 65809.53235762565 73590.09224511092 1.2329472633962544 1.3330013273372958 1.16996268702657 1.0013544593519987 0.9939349176118312 0.9006215369477176 1.196443638297079 1.0525020589194394 0.8942716383399807 1.0 16.16722392258412 -5.5883649531045965 3.266379399960648 1.0106822346202904 1.2807402707737123 0.6528367362853599 0.08257559727584167 0.14968180936961242 3.21427068648878 0.02381670680428329 0.046681901819288926 2.5800911370181197e-06 5.5883649531045965 0.27005803615342194 KET(ph)QSPEQVK ddPTM_A459_Selumetinib_30min_R1 1 KETQSPEQVK 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KET(0.845)QS(0.155)PEQVK 136.27 0.042989 0.0 1265.9 1724.7 1581.9 1230.0 1224.0 1289.2 1337.2 1452.1 800.96 1216.4 True False 1295.3930069873888 1522.771322208722 1367.0866687547125 1015.2035899595652 1113.2894161147512 1276.2318184999442 1236.3339274141038 1413.5855909144486 1359.170620196165 1372.5367887393677 0.9437947438750746 1.1094575640535946 0.9960291629125213 0.7396549209380378 0.8111180882351962 0.929834325003502 0.900765602464935 1.0299072509471918 0.9902617047114058 1.0 10.422629103634305 -9.90519117305666 12.00998935030977 0.9999950350403347 0.9373305001170399 0.03192100137320564 0.10044182631648882 0.0 0.0 0.1083203797484763 0.026271551006469652 1.2439669066652127e-10 9.90519117305666 -0.06266453492329482 KETES(ph)EAEDNLDDLEK ddPTM_A459_Selumetinib_30min_R1 11 KETESEAEDNLDDLEK 16 1 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KET(0.178)ES(0.822)EAEDNLDDLEK;KET(0.028)ES(0.972)EAEDNLDDLEK;KET(0.442)ES(0.558)EAEDNLDDLEK;KET(0.114)ES(0.886)EAEDNLDDLEK;KET(0.383)ES(0.617)EAEDNLDDLEK;KETES(1)EAEDNLDDLEK;KET(0.006)ES(0.994)EAEDNLDDLEK;KET(0.036)ES(0.964)EAEDNLDDLEK;KET(0.013)ES(0.987)EAEDNLDDLEK;KET(0.317)ES(0.683)EAEDNLDDLEK;KET(0.204)ES(0.796)EAEDNLDDLEK 166.93 8.008e-06 1930116100.0 41923.58 51048.399999999994 53512.2 56605.6 38766.2 46185.43 44305.5 43155.5 28318.92 43131.76 True False 42900.317844913785 45071.6295962427 46245.537161474116 46720.494578711536 35259.804054728476 45720.846507215196 40963.500464437304 42010.875951179965 48055.13890791746 48668.14153492031 0.8814866664701383 0.9261013092908624 0.9502219666286634 0.9599810698583734 0.7244945654937102 0.9394409785384886 0.8416902551137118 0.8632110170271525 0.9874044373245071 1.0 15.57069006377042 -8.273181618159958 21.16751185140705 0.9937025531879693 0.8867271274120483 0.30339595723080515 0.06537150013514485 136.944919807421 246847.04979508216 0.06096370790333227 0.01649732653948548 5.3311190612090176e-09 8.273181618159958 -0.10697542577592101 KETES(ph)EAEDNLDDLEK ddPTM_A459_Selumetinib_30min_R2 4 KETESEAEDNLDDLEK 16 1 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KET(0.249)ES(0.751)EAEDNLDDLEK;KET(0.127)ES(0.873)EAEDNLDDLEK;KET(0.106)ES(0.894)EAEDNLDDLEK;KET(0.169)ES(0.831)EAEDNLDDLEK 127.07 0.00054864 1057231400.0 688155.0 580983.0 613228.0 547178.0 496311.0 381116.0 564478.0 488232.0 337576.0 500976.0 True False 649910.10000273 625542.5279452163 573773.5781121635 472651.41246530035 433959.9751033645 433611.26957341115 590727.3454919376 489652.67428884073 405100.63266152225 486511.5211880313 1.3358575731478866 1.2857712524827363 1.1793627758517282 0.9715112425521076 0.8919829360744856 0.8912661893690801 1.214210393310764 1.006456482455213 0.83266400695361 1.0 18.892114444631332 -5.566269119902415 2.5357303332928054 0.975133488189644 1.3109088199827033 0.6695456963573979 0.09751654361121237 0.18072393512764431 2.3262229769068608 0.029857966878638408 0.06519985346629975 2.7147564903479384e-06 5.566269119902415 0.3357753317930593 KETQS(ph)PEQVK ddPTM_A459_Selumetinib_30min_R1 4 KETQSPEQVK 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KET(0.121)QS(0.879)PEQVK;KET(0.012)QS(0.988)PEQVK;KET(0.147)QS(0.853)PEQVK;KET(0.036)QS(0.964)PEQVK 135.91 0.0034356 388080000.0 14794.1 17991.8 13530.2 12793.300000000001 12851.6 15071.0 14690.1 15443.1 9490.0 13717.800000000001 True False 15138.7737456925 15885.311691839095 11692.873156068661 10559.190314983509 11689.175049134274 14919.399423373136 13582.013929932644 15033.498821741547 16103.836877823627 15478.613252687355 0.9780445766395867 1.0262748627743594 0.755421236074787 0.682179349183639 0.7551823188750343 0.9638718391508923 0.8774696872521556 0.9712432616747156 1.0403927415802396 1.0 13.917988604062218 -7.689321078406916 1.3917561832722032 1.0218848558123135 0.8467986767740954 0.29021951611265195 0.10334765934857228 0.6355263129297228 2.29991497218252 0.09235741861061347 0.0377921346780326 2.0449322381518357e-08 7.689321078406916 -0.1750861790382181 KETQS(ph)PEQVK ddPTM_A459_Selumetinib_30min_R2 4 KETQSPEQVK 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KET(0.019)QS(0.981)PEQVK;KET(0.017)QS(0.983)PEQVK;KET(0.28)QS(0.72)PEQVK;KET(0.241)QS(0.759)PEQVK 127.3 0.0059452 225223300.0 118653.0 187746.0 95288.0 127171.0 99331.0 79010.0 120452.0 116633.0 92345.0 134638.0 True False 112058.7412655925 202145.51450146112 89157.27382172979 109850.09041778893 86852.15174959318 89892.91031863069 126053.25667110986 116972.3827203675 110816.58033488209 130750.65110846511 0.8570415544059768 1.5460383010541943 0.6818877999144245 0.8401494714291099 0.6642578909801709 0.6875140548559059 0.9640736440122314 0.8946217990404671 0.8475413269105132 1.0 16.996458605219658 -5.282831932725097 24.99646519356052 0.8139555224983482 1.2015400365384918 0.38996976513041604 0.1893848641946851 643.2385674027631 751601.3618872042 0.04693435801557087 0.09784602066131871 5.213964468625817e-06 5.282831932725097 0.3875845140401436 KETQS(ph)PEQVKSEK ddPTM_A459_Selumetinib_30min_R1 1 KETQSPEQVKSEK 13 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KET(0.003)QS(0.991)PEQVKS(0.006)EK 171.81 0.0062716 7395000.0 1070.9 1508.9 3675.8 3792.4 1897.7 2055.3 1440.2 1562.9 1201.4 1070.4 True False 1095.8498863913378 1332.2372865314217 3176.646549724112 3130.1285321647615 1726.0533700661476 2034.6255480630898 1331.564554488327 1521.4468149853244 2038.6880532157322 1207.7962665789369 0.9073135235757225 1.103031465981396 2.630117874699109 2.5916030863638944 1.4290931490914156 1.6845767819982862 1.102474474656195 1.2596882910516005 1.687940350229996 1.0 10.238161403244968 -6.930197503724998 2.2326737265848386 1.2932776999713385 1.8054849489103362 0.13500369240062637 0.5503950501880118 0.6879909464584752 6.960363422223394 0.25266470927481455 0.20854004203161342 1.1743633692718983e-07 6.930197503724998 0.5122072489389977 KETQS(ph)PEQVKSEK ddPTM_A459_Selumetinib_30min_R2 1 KETQSPEQVKSEK 13 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 KET(0.028)QS(0.971)PEQVKSEK 87.99 0.027576 19205000.0 44421.0 79499.0 70998.0 68324.0 53632.0 29921.0 26280.0 21723.0 10759.0 58887.0 True False 41952.25865135216 85596.31767042547 66430.06597677771 59018.15333452585 46894.26868383665 34042.34615420514 27502.072072832078 21786.21033356376 12911.100631577212 57186.77930319947 0.7336006532021121 1.4967850736374053 1.1616332793384134 1.0320244303603214 0.8200194040515413 0.5952835002949807 0.4809166105861359 0.38096585607759287 0.22577072513777435 1.0 15.803394036373351 -6.518767323088961 1.5067356248727632 0.471283517204301 1.1621314081766783 0.5245199607317692 0.2546162300951305 0.2746296529839128 1.274388770310634 0.09935935446322511 0.11009787552056387 3.0285355568523946e-07 6.518767323088961 0.6908478909723772 KETSFGS(ph)SENITMTSLSK ddPTM_A459_Selumetinib_30min_R1 2 KETSFGSSENITMTSLSK 18 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 KET(0.001)S(0.001)FGS(0.941)S(0.056)ENITMTSLSK;KETSFGS(0.934)S(0.065)ENITMTSLSK 115.5 0.00054489 86118000.0 9290.1 10156.3 12486.8 13712.1 10998.7 9792.6 10266.8 10086.8 5283.5 8159.799999999999 True False 9506.541254612162 8967.195674464228 10791.161145082706 11317.539142995583 10003.869526978202 9694.095334969397 9492.367010151898 9819.265297455997 8965.713608427941 9207.189813182744 1.0325127913623342 0.9739340511504504 1.1720363502913833 1.2292066713766743 1.086527999309277 1.0528831849528624 1.0309733157190744 1.0664779912972893 0.9737730828130576 1.0 13.168545173743814 -6.897370128528562 2.7309703446999554 1.0242962177151775 1.103492992755271 0.23459953175408066 0.06887987148276568 0.4928842119436388 7.442755877287806 0.030166750779677808 0.025852967928922853 1.266571966710487e-07 6.897370128528562 0.07919677504009348 KETSFGS(ph)SENITMTSLSK ddPTM_A459_Selumetinib_30min_R2 2 KETSFGSSENITMTSLSK 18 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 KET(0.003)S(0.019)FGS(0.943)S(0.035)ENITMTSLSK;KET(0.007)S(0.02)FGS(0.932)S(0.038)ENIT(0.002)MTSLSK 115.11 0.00054931 23213000.0 156019.0 152374.0 168473.0 174672.0 180785.0 119358.0 115284.0 133337.0 93092.0 146136.0 True False 147348.0885735423 164060.59584036763 157633.63059953286 150881.3722739933 158073.17206159385 135798.48107595398 120644.93443091214 133724.98859487148 111713.00120780586 141916.67397307287 1.0382718566353943 1.156034673356961 1.1107477802745158 1.0631687457854415 1.11384496011784 0.9568888367671318 0.8501110620292806 0.9422782034776571 0.7871731917068616 1.0 17.114684577894863 -6.8919041469091615 3.6112435385419954 0.8908453761624505 1.0989927430259285 0.7184475786768886 0.06001949515795397 0.11588903714593952 2.915323079574647 0.020908651571219985 0.018240891690779783 1.2826136369435196e-07 6.8919041469091615 0.208147366863478 KETTSGTSTEPVKNS(ph)SPAPPQPAPGK ddPTM_A459_Selumetinib_30min_R1 1 KETTSGTSTEPVKNSSPAPPQPAPGK 26 2 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 KETTSGTSTEPVKNS(0.5)S(0.5)PAPPQPAPGK 86.76100000000002 3.012e-05 60347000.0 1989.9 2118.7 2735.5 2799.2 2145.8 1923.3 1996.7 2159.1 1284.2 1736.6 True False 2036.2607983286248 1870.641619043093 2364.0341250259276 2310.372267491719 1951.7127688717603 1903.9533482166792 1846.0873114476078 2101.8336542547936 2179.193605743004 1959.5095259164607 1.0391686140827856 0.9546478821878632 1.2064417619609535 1.1790564102571333 0.9960210670366332 0.9716479164990035 0.9421170384891059 1.0726325268930592 1.1121117692570528 1.0 10.93627687110516 -6.307560197714456 24.917625772448805 1.0134994040504988 1.0927882724456066 0.19219742215569058 0.07929249321438428 771.7351335566341 416942.31559193006 0.02710235284470422 0.03073127784899914 4.925380677389803e-07 6.307560197714456 0.07928886839510785 KETTSGTSTEPVKNS(ph)SPAPPQPAPGK ddPTM_A459_Selumetinib_30min_R2 1 KETTSGTSTEPVKNSSPAPPQPAPGK 26 2 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 KETTSGTS(0.001)T(0.003)EPVKNS(0.498)S(0.498)PAPPQPAPGK 72.167 0.00020763 37210000.0 133460.0 165350.0 146610.0 140740.0 142490.0 98238.0 68238.0 88140.0 57472.0 138200.0 True False 126042.82748271008 178031.8133159517 137177.2722168985 121570.96920995797 124589.13232323754 111769.39278422532 71411.20221103188 88396.4728076375 68968.0059018501 134209.8069132772 0.9391476702157511 1.3265186606742614 1.022110644310358 0.9058277633058059 0.9283161580266912 0.8327960180767395 0.5320863195725771 0.6586439161242289 0.5138820141989727 1.0 17.034130569732113 -6.440327095893937 1.0222234272719024 0.6526370799539778 1.1204133108638799 0.5107171931663896 0.16326832151358425 0.37891146529079744 0.8462574540463204 0.07711683963144493 0.09798144736985073 3.6280469963077293e-07 6.440327095893937 0.46777623090990206 KETTSGTSTEPVKNSS(ph)PAPPQPAPGK ddPTM_A459_Selumetinib_30min_R1 1 KETTSGTSTEPVKNSSPAPPQPAPGK 26 2 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 KETTSGTS(0.007)T(0.007)EPVKNS(0.224)S(0.759)PAPPQPAPGK 69.27 0.00039414 45228000.0 4524.4 4450.0 6576.0 5978.9 5300.6 4962.6 5358.8 5246.1 3071.1 3844.1 True False 4629.809717050113 3928.9919312511247 5683.015319382381 4934.797352853045 4821.161665896941 4912.680749680287 4954.581401605368 5106.956386265607 5211.432395730677 4337.527679704866 1.0673844777320556 0.9058136849788266 1.3101968999467144 1.1376981813724858 1.1114999192869661 1.1325992852256692 1.1422593162431387 1.1773887715255096 1.2014753058786873 1.0 12.082657248864923 -5.24496200438073 24.999480618983235 1.1550285250850802 0.9865990856095678 0.39474344282314533 0.08165913478196092 765.4150389066199 1161283.7770831576 0.019578602559449584 0.0514881350320621 5.689027009095233e-06 5.24496200438073 -0.16842943947551248 KEVLAS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 2 KEVLASPDR 9 1 Q9C0C2;E9PKK0 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 KEVLAS(1)PDR;KEVLAS(1)PDR 81.709 0.022171 42806000.0 367650.0 295780.0 357980.0 411090.0 426720.0 364070.0 405730.0 429440.0 432730.0 342850.0 True False 347217.4848195589 318465.3749174008 334947.95653915417 355098.83283019473 373111.61867479817 414217.33780159353 424597.24893874256 430689.5993023811 519288.09148642246 332951.02966872114 1.0428485088784154 0.9564931372468402 1.005997659392794 1.066519701661563 1.120620107545653 1.2440788611278077 1.2752543500502382 1.2935523873613115 1.5596530576977117 1.0 18.344950476209725 -6.607171594977615 1.2335045741464137 1.3125923499689676 0.9975362809022276 0.47335469419067544 0.1282945831559085 0.35638861265223803 1.1404055185857682 0.05696679628920917 0.05937273320945929 2.4707477299624564e-07 6.607171594977615 -0.31505606906674 KEVS(ph)PEVVR ddPTM_A459_Selumetinib_30min_R1 1 KEVSPEVVR 9 1 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 KEVS(1)PEVVR 73.632 0.03279 103070000.0 4967.5 6369.1 6972.5 7761.5 6708.2 5920.6 6367.3 5641.9 3305.8 5011.6 True False 5083.233084927607 5623.402811085739 6025.672797200976 6406.099726399321 6101.444494428903 5861.044139474689 5887.009434657357 5492.25848452601 5609.701153920901 5654.887677117901 0.8989096468700071 0.994432273843464 1.065568962860824 1.1328429656208991 1.078968291292144 1.0364563319605773 1.0410479872975584 0.9712409508592083 0.9920092978363046 1.0 12.465282652948916 -10.416485562404889 13.831331118128059 0.9999999999390101 1.0280878790899304 0.00811461992658824 0.06128476504591831 0.0 0.0 0.06488209985952151 0.015736220643098823 3.8327848181809933e-11 10.416485562404889 0.02808787915092026 KEVS(ph)PEVVR ddPTM_A459_Selumetinib_30min_R2 1 KEVSPEVVR 9 1 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 KEVS(1)PEVVR 74.237 0.031893 150430000.0 277780.0 265220.0 282600.0 305160.0 297040.0 199090.0 217510.0 243600.0 180850.0 198820.0 True False 262342.0996414446 285561.52118328743 264417.8236716157 263596.6815696378 259723.1796287072 226512.84034092128 227624.6459878886 244308.83566984886 217025.05337120022 193079.55000360197 1.3587254560959487 1.4789837721185914 1.3694760717366643 1.3652232023780888 1.3451615130854717 1.1731581119631551 1.1789163895588226 1.2653273516811656 1.1240188480196456 1.0 17.558835843951975 -7.183244553994994 0.27047385532565466 0.9749906878328125 1.5219538564333877 0.8395886027517931 0.05490070756026144 0.913832372546551 0.18525649417220869 0.10400615541309226 0.17936892346133665 6.557758907237082e-08 7.183244553994994 0.5469631686005751 KEVVEEAENGR ddPTM_A459_Selumetinib_30min_R1 1 KEVVEEAENGR 11 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 103.44 0.017979 15525000.0 3836.3 4487.5 4049.2 4235.2 4050.6 3645.7 4445.2 4470.3 2963.2 3714.3 False True 3925.6783258596424 3962.1014138178502 3499.340880663491 3495.601824550204 3684.223945191513 3609.0275680307527 4109.894985148947 4351.733122419155 5028.333976434875 4191.0665853457995 0.9366776322728693 0.9453682811128477 0.8349523467126603 0.8340601976529529 0.8790659537773802 0.861123891624589 0.9806322332170355 1.0383354770919486 1.199774299462721 1.0 12.033101727052854 -7.635240985499526 2.1560459977286777 1.1000144206934743 0.8806462430041342 0.6979732542063763 0.058530130044071524 0.17151685442598769 1.5893022682794309 0.03675966164553485 0.017362524584382488 2.3161091084342754e-08 7.635240985499526 -0.21936817768934014 KEWSGLLEELAR ddPTM_A459_Selumetinib_30min_R1 1 KEWSGLLEELAR 12 1 Q01813;Q01813-2;Q5VSR5;V9GYV7 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 102.97 0.015050999999999997 4272100.0 2276.4 2855.9 3160.2 3410.1 3312.6 2559.9 2750.4 2498.3 1366.1 1850.8 False True 2329.4356908966665 2521.529900328111 2731.0621977360383 2814.59005050497 3012.9759148870307 2534.149730203233 2542.935113640255 2432.036968377913 2318.1719240036723 2088.3682083186604 1.1154334190770356 1.2074163407985357 1.3077493647228087 1.3477460724088444 1.4427417075616036 1.2134592549862029 1.217666072252443 1.1645632981244909 1.1100398458325633 1.0 11.028160386168802 -8.162001068173819 1.0437314563253581 1.0095369637117235 1.2805925644572407 0.5298233639671321 0.08336262792804246 0.4233076689096174 0.9025393294784477 0.08600063148401858 0.029896613886044705 6.886506025639516e-09 8.162001068173819 0.27105560074551716 KEYEEDDILAS(ph)DDPSSIEQYENTR ddPTM_A459_Selumetinib_30min_R1 1 KEYEEDDILASDDPSSIEQYENTR 24 1 Q96RS0 Q96RS0 TGS1 Trimethylguanosine synthase 1 KEYEEDDILAS(1)DDPSSIEQYENTR 93.416 1.1704e-05 4281500.0 1520.3 1817.0 2209.4 2250.6 2045.4 1877.4 1779.4 1525.2 1066.0 1455.1 True False 1555.7200320111604 1604.2647952996174 1909.375615365486 1857.574958994308 1860.3939311446995 1858.515060542814 1645.1784253968412 1484.746741452184 1808.9241424404627 1641.8762588742625 0.9475257490341116 0.9770923884358782 1.1629229700139718 1.131373298660118 1.1330902198563135 1.1319458762483647 1.002011215220837 0.9042988065800934 1.1017420665310886 1.0 10.68112968617765 -7.355782405693548 7.3665487796090385 0.9931149374563458 1.0842547036149752 0.18698197693201635 0.07938399220335728 0.4627032709332412 31.69988153229976 0.03578848640556495 0.024023222679756755 4.407756497538664e-08 7.355782405693548 0.0911397661586294 KEYEEDDILAS(ph)DDPSSIEQYENTR ddPTM_A459_Selumetinib_30min_R2 3 KEYEEDDILASDDPSSIEQYENTR 24 1 Q96RS0 Q96RS0 TGS1 Trimethylguanosine synthase 1 KEYEEDDILAS(1)DDPSSIEQYENTR;KEYEEDDILAS(1)DDPSSIEQYENTR;KEY(0.001)EEDDILAS(0.999)DDPSSIEQYENTR 117.62 7.7275e-08 16619900.0 148374.0 124232.0 134584.0 143642.0 159651.0 130346.0 126748.0 122613.0 101649.0 148100.0 True False 140127.96706818248 133760.1949311596 125925.01196397952 124077.71180372863 139594.2140819511 148299.97833682128 132642.0331463973 122969.78353032506 121981.64031036288 143823.96818998802 0.9743019110909024 0.9300271478705524 0.8755495592892806 0.862705384681258 0.970590756455492 1.0311214479976005 0.92225263157237 0.8550020214147125 0.8481315169195447 1.0 17.133944594632702 -10.67159078235747 5.097063727468977 1.000002750882073 0.9193028259993852 0.1537839816596388 0.057096440561939084 2.642817063877811e-06 4.414269251641722e-07 0.060918605904761676 0.014774255516023727 2.130145247999651e-11 10.67159078235747 -0.08069992488268785 KEYEQELSDDLHVER ddPTM_A459_Selumetinib_30min_R1 1 KEYEQELSDDLHVER 15 1 X6R631;Q7Z7F7;Q7Z7F7-2 X6R631 MRPL55 39S ribosomal protein L55, mitochondrial 0 103.88 0.0036226 3436000.0 1435.6 1545.8 1696.7 1454.0 1579.9 1725.0 1352.2 1427.3 708.64 1084.0 False True 1469.0466868086692 1364.8170173770764 1466.297459305974 1200.0861949603318 1436.9983239540002 1707.6480661746841 1250.2024653375336 1389.443367476201 1202.5103229821843 1223.1419590541539 1.201043489624599 1.1158287942574374 1.1987958130713219 0.9811503775803334 1.1748418189048309 1.3961160056149124 1.0221237658336122 1.1359624753210549 0.9831322636597932 1.0 10.25637613884474 -8.042742009556806 1.6741912670522332 0.9915308953166329 1.1620966017661711 0.27276663426425074 0.10592347565243325 0.5488305578228707 2.7503548045963098 0.09592712440552746 0.031159831036339687 9.062708066179445e-09 8.042742009556806 0.17056570644953828 KFDHESS(ph)PGTDEDKSG ddPTM_A459_Selumetinib_30min_R2 2 KFDHESSPGTDEDKSG 16 2 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 KFDHES(0.2)S(0.759)PGT(0.04)DEDKS(0.001)G;KFDHES(0.044)S(0.956)PGTDEDKSG 101.2 0.0021936 10552300.0 31064.9 27750.7 40357.0 62132.0 67245.0 38191.5 36375.1 36276.1 36093.8 54765.0 True False 29338.437220647684 29879.089457435595 37760.47455737927 53669.5144163217 58797.08192207248 43452.0324570812 38066.61422589325 36381.657445168334 43313.568545034075 53183.792153441675 0.5516424465559496 0.5618081796655419 0.7099996639659641 1.0091329001414313 1.105545120822445 0.8170164386119145 0.715755922707927 0.6840741506397824 0.8144129403196596 1.0 15.698699028612536 -5.498297149502845 4.200400930558637 0.8655581712349814 0.5660279010612039 0.5128198004573881 0.12574366110551213 0.19816543923149446 8.019786166487007 0.039146490225835044 0.08027109099462922 3.17470115868946e-06 5.498297149502845 -0.2995302701737774 KFDQLLAEEK ddPTM_A459_Selumetinib_30min_R1 1 KFDQLLAEEK 10 1 P35579;A0A0C4DFM8;P35579-2;P35749-4;P35749-3;P35749;P35749-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4;Q7Z406;Q7Z406-6;Q7Z406-2;A1L2Z2 P35579;P35579-2;P35749-4;P35580;Q7Z406 MYH9;MYH14;MYH11;MYH10 Myosin-9;Myosin-11;Myosin-10;Myosin-14 0 93.623 0.033770999999999995 8832200.0 2755.4 2867.5 3246.5 3775.0 3456.5 3237.2 2998.0 2933.0 2235.6 2972.3 False True 2819.5954589249154 2531.771766935417 2805.6431317480065 3115.7671155263097 3143.860185294639 3204.6367071424274 2771.8584462963527 2855.2073122733113 3793.6499182362995 3353.823657653749 0.8407107071626521 0.7548911407902051 0.8365505817055284 0.9290193622481697 0.9373957924472407 0.9555173539995574 0.8264770987498715 0.8513289915399854 1.131141737156879 1.0 11.711591119385263 -1.5229064258255423 0.14996913955102445 1.0401487431268417 0.0977676127562478 0.40116239222427585 0.07919134986587695 75.28632265067782 0.7429016106554021 0.291603854641539 15.427651142531225 0.029998087956611793 1.5229064258255423 -0.9423811303705939 KFELLPTPPLS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 KFELLPTPPLSPSR 14 1 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1;P04198 H0YBT0 MYC;MYCN Myc proto-oncogene protein;N-myc proto-oncogene protein 1 KFELLPT(0.005)PPLS(0.944)PS(0.051)R 110.37 0.0021932 23416000.0 8906.3 10197.0 9862.1 10102.0 9439.4 8316.6 9508.6 7516.2 4440.7 6842.6 True False 9113.799461356957 9003.130499543315 8522.880988637615 8337.875338025633 8585.60793666143 8232.942554868632 8791.358646582226 7316.845959941582 7535.543564104462 7720.914362568226 1.1804041637272367 1.1660705036687626 1.1038693849471255 1.0799077604653273 1.1119936750348283 1.0663170407358447 1.1386421651305476 0.9476657318483406 0.9759910821751293 1.0 12.914555995915622 -7.108534063405643 0.49108820464677666 0.9667929176319938 1.1635552728897565 0.6528354042840867 0.04462202189636525 0.6542144223311366 0.3408904377596989 0.045201807879651806 0.04640132968460304 7.788717222188248e-08 7.108534063405643 0.19676235525776264 KFELLPTPPLS(ph)PSRR ddPTM_A459_Selumetinib_30min_R1 1 KFELLPTPPLSPSRR 15 2 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 KFELLPTPPLS(0.5)PS(0.5)RR 74.51899999999998 0.015821 16628000.0 4244.0 4847.2 6365.1 6300.8 4569.3 4821.7 4736.4 4642.3 2686.8 3408.0 True False 4342.87694261354 4279.687570597855 5500.754380991601 5200.483560664415 4156.007621775437 4773.198075753319 4379.129534702481 4519.171123684418 4559.30336389215 3845.4499967311403 1.129354677945427 1.1129224341067605 1.4304579140718425 1.3523732112197877 1.080759761616531 1.2412586510839614 1.1387820771106112 1.1751995546752603 1.1856358469796322 1.0 11.908936717716706 -6.2692272307142725 24.946023860034796 1.1510074014221672 1.2584789339025375 0.22423939212193766 0.10680345797167605 1061.8157574134893 3401199.3252651263 0.03464609910596709 0.03999113777857528 5.379882237121724e-07 6.2692272307142725 0.10747153248037034 KFELLPTPPLS(ph)PSRR ddPTM_A459_Selumetinib_30min_R2 1 KFELLPTPPLSPSRR 15 2 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 KFELLPTPPLS(0.5)PS(0.5)RR 63.99800000000001 0.027457 3769100.0 22539.0 20266.0 22648.0 22453.0 20937.0 15917.0 17673.0 19928.0 15158.0 21833.0 True False 21286.372610765782 21820.337034539294 21190.852337277945 19394.862666414592 18306.706880845155 18109.42226986007 18494.829518385144 19985.987180742002 18190.023549906804 21202.62456105344 1.0039498907067466 1.029133774062128 0.9994447751625467 0.914738767861811 0.863417018404046 0.8541122924529262 0.8722896292923011 0.9426185481515224 0.8579137690019563 1.0 14.371955239000888 -5.777152297267642 3.374397135891174 0.8917454199389688 1.0162599071278478 0.5813218008384431 0.04291503107357145 0.14866825409552067 3.5278269877461073 0.011859060795766905 0.020084012832089923 1.6705047033074272e-06 5.777152297267642 0.12451448718887892 KFELLPTPPLSPS(ph)RR ddPTM_A459_Selumetinib_30min_R1 1 KFELLPTPPLSPSRR 15 2 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 KFELLPTPPLS(0.074)PS(0.926)RR 83.948 0.025453 24898000.0 3778.1 4802.5 5343.5 5791.9 5677.9 4834.8 4298.7 4150.5 2416.0 3020.2 True False 3866.1223790971253 4240.221067378319 4617.882049744484 4780.4533924283005 5164.334947514662 4786.166301647166 3974.4455980967755 4040.415257275957 4099.775542341609 3407.8720892392585 1.134468160147455 1.2442430221390341 1.3550631974498013 1.402767846693285 1.5154133759367419 1.4044442327398459 1.1662543352629158 1.1856123561779286 1.2030309339623146 1.0 11.734655471257723 -8.165715743147441 0.9525253940246712 1.0291818951061689 1.3401040993912374 0.4588440785705984 0.10828577988685255 0.5250133066090924 0.9541674670608791 0.11383135993935241 0.04109737403615787 6.827854484690294e-09 8.165715743147441 0.31092220428506856 KFGDPVVQSDMK ddPTM_A459_Selumetinib_30min_R2 2 KFGDPVVQSDMK 12 1 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 ; 99.011 0.019968 12498100.0 190821.0 181316.0 191551.0 205729.0 200945.0 140679.0 164016.0 168308.0 115724.0 182148.0 False True 180215.93273698646 195222.35417717037 179226.81720495943 177708.35529767966 175700.49262890717 160056.25529318614 171643.06899153846 168797.74841511052 138872.03359872155 176888.91396266018 1.0188085205556103 1.1036438056167852 1.0132167878129026 1.0046325194533812 0.9932815386384028 0.9048405109603009 0.9703438454473802 0.9542584927099634 0.7850804806684285 1.0 17.432484108263566 -6.295232563781186 0.842775508420964 0.9139236104290184 1.0631658687419634 0.45517816059415317 0.05868384971750962 0.5628116720571908 0.8638607005281408 0.030517239068571546 0.0489730021355773 5.067192884961155e-07 6.295232563781186 0.14924225831294502 KFGYVDFESAEDLEK ddPTM_A459_Selumetinib_30min_R1 2 KFGYVDFESAEDLEK 15 1 P19338 P19338 NCL Nucleolin 0 ; 171.78 5.883100000000001e-05 47250000.0 12761.8 14178.7 16326.3 17229.800000000003 14038.7 13297.3 12942.8 13034.9 8390.2 11509.5 False True 13059.125109859906 12518.651212501207 14109.278133946545 14220.938873402696 12768.902063733798 13163.541234982387 11966.514175691944 12689.172108677596 14237.556604037485 12986.8564370238 1.0055647548878786 0.9639477631255088 1.0864275124904645 1.0950254930716483 0.983217310952276 1.0136048934409472 0.9214326987997653 0.9770780304079172 1.0963050737550395 1.0 13.66476463777469 KFNSLPQYS(ph)PVTFDR ddPTM_A459_Selumetinib_30min_R1 1 KFNSLPQYSPVTFDR 15 1 C9JA69;Q8WY36-2;Q8WY36 C9JA69 BBX HMG box transcription factor BBX 1 KFNS(0.001)LPQYS(0.667)PVT(0.332)FDR 67.866 0.030332 14096000.0 2983.6 4341.5 3500.2 3712.7 2921.1 3453.6 3277.4 3026.7 1779.5 2964.4 True False 3053.1120749250135 3833.195161691408 3024.892065222353 3064.3466410104716 2656.8870207620926 3418.8599196179093 3030.1830793501217 2946.422083892816 3019.6815304622905 3344.9096157012314 0.912763699381741 1.1459786966135441 0.9043269961685378 0.9161224048106477 0.7943075676217036 1.0221083115578222 0.9059088069603549 0.8808674739855785 0.902769245628552 1.0 11.707751512347553 -5.318799233939946 24.98993783685562 0.910662332402906 1.0293716524590435 0.24727611490866763 0.07885243522697259 294.0965093755787 128128.27898838177 0.019436709151527006 0.040460773160165636 4.799552715331616e-06 5.318799233939946 0.11870932005613755 KFPVFNPATEEELCQVEEGDKEDVDK ddPTM_A459_Selumetinib_30min_R1 2 KFPVFNPATEEELCQVEEGDKEDVDK 26 2 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 171.42 1.5174000000000006e-17 199025000.0 7238.8 9304.2 11763.1 13108.900000000001 8560.5 9701.0 8291.3 8712.2 5633.0 8155.799999999999 False True 7407.449955747145 8214.859938594771 10165.735630083163 10819.676699529226 7786.20428647903 9603.416747803252 7665.8805656360755 8481.124154786075 9558.7895819579 9202.676374219445 0.8049234434124531 0.8926598746434284 1.1046499101676173 1.175709789147826 0.8460804194192303 1.0435460682618862 0.8330055577213843 0.9215932202663629 1.0386967000965153 1.0 13.167837779559209 KFPVFNPATEEELCQVEEGDKEDVDK ddPTM_A459_Selumetinib_30min_R2 2 KFPVFNPATEEELCQVEEGDKEDVDK 26 2 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 214.86 4.8064e-34 66957200.0 321264.0 296797.0 284079.0 251142.0 224628.0 188678.0 237954.0 245949.0 151074.0 255649.0 False True 303409.43300168816 319560.3755472301 265801.666421829 216936.0263558855 196408.22244020097 214666.68185164663 249019.332496906 246664.67087095094 181293.02136024652 248267.74911412733 1.2221057067795482 1.28716024005329 1.0706250303161264 0.873798659431037 0.7911145251085883 0.8646579453739902 1.0030273097712468 0.9935429460777869 0.7302318646184974 1.0 17.921537336776886 -5.519199740809523 3.022321848760964 0.8929269189266799 1.2524781115891312 0.7357981306355958 0.08674400306045002 0.12822419722771683 2.373532544592145 0.02494321478884746 0.05372429850796075 3.0255216095276605e-06 5.519199740809523 0.3595511926624514 KFQEQECPPS(ph)PEPTR ddPTM_A459_Selumetinib_30min_R1 1 KFQEQECPPSPEPTR 15 1 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 KFQEQECPPS(0.958)PEPT(0.042)R 101.05 0.003692 22198000.0 5180.1 5015.3 5823.2 3688.8 5756.7 5096.6 4728.4 6517.8 2582.6 5177.6 True False 5300.786251280016 4428.106344450285 5032.441424547971 3044.6203273519086 5236.007501427931 5045.33283134255 4371.732981143321 6344.9267712018345 4382.483574359043 5842.195394094827 0.9073277926715603 0.7579524554974874 0.8613956030355748 0.5211431871021208 0.8962397092573079 0.8636022061915749 0.7483031097457268 1.086051791012529 0.7501432729875431 1.0 12.512294895033484 -7.730626140063625 24.99913851877773 0.9385735114348024 0.7910855638791062 0.2190513603101648 0.1309953980686466 294.4978027030853 238929.63462170845 0.05961155731753847 0.03441209407713052 1.8594044240610742e-08 7.730626140063625 -0.14748794755569616 KFQEQECPPS(ph)PEPTR ddPTM_A459_Selumetinib_30min_R2 1 KFQEQECPPSPEPTR 15 1 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 KFQEQECPPS(0.999)PEPT(0.001)R 113.14 0.0050915 3236800.0 5247.2 2225.0 3774.6 3992.9 2138.6 2746.3 7060.7 4249.9 3147.8 3503.8 True False 4955.581630205874 2395.6503454973817 3531.7463454737417 3449.060131863305 1869.9299486734226 3124.577896570755 7389.036540511625 4262.266505391179 3777.447956880634 3402.6361900343077 1.456394793166503 0.7040571520733832 1.0379441551281838 1.0136435220329945 0.5495533005115568 0.9182815094138086 2.1715623204598677 1.2526365639308044 1.110153347555663 1.0 11.732437191212814 KFQEQECPPS(ph)PEPTRK ddPTM_A459_Selumetinib_30min_R1 1 KFQEQECPPSPEPTRK 16 2 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 KFQEQECPPS(0.99)PEPT(0.01)RK 94.188 0.010641 10772000.0 2063.6 1508.7 2702.4 1647.2 2456.9 2024.5 1902.8 2374.9 1298.4 1683.3 True False 2111.6778649333887 1332.0607026243988 2335.428923220643 1359.5474417734936 2234.673828800927 2004.135368098926 1759.2702640469306 2311.909937237604 2203.2899686160363 1899.3679517304972 1.1117792437265555 0.7013178786189217 1.229582146572945 0.7157893974860543 1.176535503173535 1.0551590945150864 0.9262398380703829 1.217199613761643 1.160012185426546 1.0 10.891303700794744 -6.3291141358729 24.999949786613968 1.0902018221363896 0.9432988698633288 0.1582111782509964 0.16892684769100524 334.67564548866545 123632.36550649765 0.049493546699203736 0.05612041225139266 4.686901906329747e-07 6.3291141358729 -0.14690295227306083 KFQEQECPPS(ph)PEPTRK ddPTM_A459_Selumetinib_30min_R2 1 KFQEQECPPSPEPTRK 16 2 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 KFQEQECPPS(0.929)PEPT(0.071)RK 77.959 0.030478 4866400.0 15511.0 3856.4 7584.6 11808.0 6624.6 3830.3 12253.0 6994.3 6959.1 6620.0 True False 14648.960715452677 4152.173479719596 7096.615093488093 10199.730030063844 5792.358523324584 4357.889056998494 12822.788778858883 7014.652255031304 8351.114453500228 6428.863399174358 2.278623732670071 0.6458643187616723 1.1038677683522553 1.5865526138529817 0.9009926271055131 0.6778630663638251 1.9945654437930163 1.091118572519705 1.2990032506481222 1.0 12.650347981263712 -4.7438748797335935 24.914898545174147 1.1642013819207395 2.2786272886973014 0.4354454625969565 0.3868433164635317 1062.900506341113 1507620.3382496047 0.09595765161834013 2.902964572981811 1.803537265213264e-05 4.7438748797335935 1.1144259067765618 KFQEQECPPSPEPT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 KFQEQECPPSPEPTR 15 1 P62070-2;P62070-3;P62070;P62070-4 P62070-2 RRAS2 Ras-related protein R-Ras2 1 KFQEQECPPS(0.044)PEPT(0.956)R 135.57 0.0092056 0.0 1523.1 1580.4 1715.3 1616.0 1031.1 1499.0 1212.5 1760.7 1168.9 1082.0 True False 1558.5852665633083 1395.3660332919733 1482.3716814684594 1333.7959360769585 937.8371870554902 1483.9214209831025 1121.0401488106495 1714.000516440374 1983.537926921817 1220.8852395725053 1.2766025962514291 1.1429133452219986 1.214177740397217 1.0924826452517267 0.7681616229416249 1.2154470976344178 0.9182191023975221 1.4038997777059978 1.624671887765926 1.0 10.253711881317685 -7.7813850705109155 24.795474008062204 1.3857146195676704 1.0891228819090006 0.240268319106125 0.20201020422789875 278.1679880238973 345799.02139480034 0.10744833630218745 0.051728026935506315 1.6543025130766276e-08 7.7813850705109155 -0.29659173765866975 KFS(ph)EPNTYIDGLPSQDR ddPTM_A459_Selumetinib_30min_R2 1 KFSEPNTYIDGLPSQDR 17 1 Q8N4X5-2;Q8N4X5;Q8N4X5-4;Q8N4X5-3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 KFS(1)EPNTYIDGLPSQDR 74.444 0.011907 4051600.0 25075.0 15322.0 16817.0 23646.0 17699.0 11701.0 16376.0 20637.0 17180.0 16705.0 True False 23681.431883178124 16497.148132004895 15735.012528965164 20425.374008374798 15475.49338893245 13312.706538897579 17137.516448428396 20697.05025336073 20616.48004930724 16222.683245197548 1.4597728085573398 1.0169185875516986 0.9699389608450408 1.2590626161933716 0.9539416602684213 0.8206229720252093 1.0563922249731201 1.2758093060522366 1.2708427907824928 1.0 13.985724841791466 -11.326923434340834 13.299676569945417 0.9997375819385004 1.105958591460466 0.031986149088389815 0.18386768531360406 0.0014851052753860122 2.1881108991326492e-05 0.18480145804405462 0.0447130873318572 4.710603665226465e-12 11.326923434340834 0.10622100952196556 KFSGFSAKPNNSGEAPS(ph)SPTPK ddPTM_A459_Selumetinib_30min_R1 2 KFSGFSAKPNNSGEAPSSPTPK 22 2 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 KFSGFSAKPNNS(0.006)GEAPS(0.567)S(0.412)PT(0.016)PK;KFSGFSAKPNNS(0.003)GEAPS(0.562)S(0.413)PT(0.022)PK 89.272 0.00051721 144123000.0 4946.9 5659.0 6747.9 7308.5 5219.4 4907.4 4814.9 4932.5 2854.3999999999996 4492.6 True False 5062.1531450082275 4996.441649202274 5831.572243561492 6032.207672536163 4747.306191559913 4858.036011562693 4451.708216501771 4801.674076981965 4843.708322872474 5069.26897162979 0.998596281503036 0.9856335651481318 1.1503773574055627 1.1899561270659473 0.9364873353787805 0.9583306860911771 0.8781755794407037 0.9472123305854508 0.9555043044628982 1.0 12.307561998942917 -6.297206070255748 24.70156521838092 0.9405424304973433 1.0792643568087534 0.5181718924976528 0.06372584446559394 442.02416349556574 305274.0513473987 0.02146042384707825 0.024334995109975787 5.044218954568702e-07 6.297206070255748 0.13872192631141012 KFSGFSAKPNNSGEAPSS(ph)PTPK ddPTM_A459_Selumetinib_30min_R1 1 KFSGFSAKPNNSGEAPSSPTPK 22 2 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 KFSGFSAKPNNSGEAPS(0.165)S(0.774)PT(0.061)PK 50.957 0.018992 144750000.0 8417.4 9332.6 10951.0 12027.0 9112.1 9080.5 9379.8 9872.7 5325.5 8088.8 True False 8613.50904259076 8239.93485339197 9463.91434953717 9926.710224750972 8287.912163871915 8989.158414434327 8672.274134279693 9610.843924950816 9036.984540869302 9127.076271584177 0.9437314629886097 0.9028011389633946 1.0369053646458164 1.0876111834034232 0.908057730346258 0.9848891525559792 0.9501700080319866 1.0530035729922382 0.9901291795933203 1.0 13.15593707214321 -5.254188848048443 24.94255150649167 1.0005725081359913 0.9232662966695778 0.28941582555444945 0.048925685417790014 715.2718415394277 2460590.109854409 0.012923260797280388 0.03269986859238816 5.569435156745593e-06 5.254188848048443 -0.07730621146641348 KFSGFSAKPNNSGEAPSS(ph)PTPK ddPTM_A459_Selumetinib_30min_R2 2 KFSGFSAKPNNSGEAPSSPTPK 22 2 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 KFSGFSAKPNNSGEAPS(0.462)S(0.469)PT(0.069)PK;KFSGFSAKPNNS(0.003)GEAPS(0.212)S(0.74)PT(0.044)PK 93.949 0.00028438 85442000.0 129804.0 130752.0 133494.0 151287.0 114929.0 93559.0 105916.0 96754.0 66681.0 123927.0 True False 122590.01332658256 140780.25796605536 124905.14137727725 130681.44961536858 100490.5915417038 106445.90300595832 110841.30386857252 97035.53812151315 80019.06322280876 120348.90550898516 1.0186217548727943 1.1697676632010983 1.0378585567440157 1.085854907135919 0.8349938133355209 0.8844775326852569 0.9209996833772385 0.8062851731897849 0.6648923219067796 1.0 16.876863495983834 -6.260218831655498 24.89264471538814 0.8473353926779622 1.081709644055525 0.6081978280545333 0.08883116439308214 69.75430262473154 1422612.578636044 0.02681214425623246 0.03270656666114219 5.49264041772842e-07 6.260218831655498 0.23437425137756274 KFSKEEPVS(ph)SGPEEAVGK ddPTM_A459_Selumetinib_30min_R1 2 KFSKEEPVSSGPEEAVGK 18 2 O00567 O00567 NOP56 Nucleolar protein 56 1 KFSKEEPVS(0.549)S(0.451)GPEEAVGK;KFSKEEPVS(0.571)S(0.429)GPEEAVGK 88.396 0.0073671 34016000.0 1314.19 1824.51 7696.2 9591.5 3817.4 2881.5 1707.08 1964.83 1233.57 1020.24 True False 1344.808070031405 1610.8955210083122 6651.098312200524 7916.524579753802 3472.116844016708 2852.514726192668 1578.313581222008 1912.716325732686 2093.2781936118963 1151.1977419791613 1.1681816433372993 1.3993213001259277 5.777546349913637 6.876772157443222 3.0160907352436066 2.4778668530817045 1.3710186561941486 1.6615011096567194 1.8183480711255497 1.0 10.168919952076475 -6.844613466724826 2.6651335305322075 1.557714168707109 3.854919042188617 0.28222315529140907 1.6427583220013822 0.4119203514834774 5.950879671575854 0.7141838131535608 0.6303138563814016 1.4301662770528658e-07 6.844613466724826 2.297204873481508 KGAAEEEQQDS(ph)GSEPR ddPTM_A459_Selumetinib_30min_R2 1 KGAAEEEQQDSGSEPR 16 1 D6RGI7;A0A499FJW5;Q9UJV9 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 KGAAEEEQQDS(0.94)GS(0.06)EPR 94.313 0.014713 0.0 8295.3 5926.6 7851.0 8109.6 10134.0 9512.6 11120.0 11556.0 10336.0 7523.6 True False 7834.280434716947 6381.151162977437 7345.875207522482 7005.058490159705 8860.876320890522 10822.874303214865 11637.102033861984 11589.626046801208 12403.488811969703 7306.374119339611 1.0722528448112167 0.8733677004147441 1.005406387291107 0.9587598959130305 1.2127597322776316 1.4812921055557848 1.5927328444705768 1.5862349583391906 1.6976257455990764 1.0 12.83493991275254 -6.573456308983515 2.327845146066425 1.5221930363144802 0.9703119633291203 0.6128684797693855 0.183134395860481 0.17578374448374537 1.930032692865123 0.06281882828172358 0.0653200162732592 2.670199381772292e-07 6.573456308983515 -0.5518810729853599 KGAANASGS(ph)SPDAPAK ddPTM_A459_Selumetinib_30min_R1 1 KGAANASGSSPDAPAK 16 1 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 KGAANAS(0.145)GS(0.787)S(0.068)PDAPAK 99.569 0.024031 0.0 365.26 599.52 528.27 499.79 744.1 578.37 514.44 615.77 120.98 565.3 True False 373.76984732776185 529.3279196907132 456.53383557939907 412.51105872023686 676.7962863815247 572.5521229179433 475.63537662198013 599.4377792971487 205.29422397040068 637.8617614882969 0.5859731212851823 0.829847392726057 0.7157253548389344 0.6467091831272995 1.061039126726116 0.8976116103621429 0.7456715629295593 0.9397612703707225 0.3218475167587974 1.0 9.317099984258924 -4.755761737853359 24.618625753306706 0.7962861654023999 0.585972712074261 0.08975244047475595 0.20002224008830877 394.0874976174113 1708573.107271169 0.04785318139790079 0.4093176389439216 1.7548429777677594e-05 4.755761737853359 -0.2103134533281389 KGAANASGS(ph)SPDAPAK ddPTM_A459_Selumetinib_30min_R2 1 KGAANASGSSPDAPAK 16 1 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 KGAANAS(0.064)GS(0.813)S(0.123)PDAPAK 71.842 0.019964 4011800.0 21138.0 16836.0 20853.0 24914.0 22700.0 20854.0 24056.0 23680.0 20860.0 25271.0 True False 19963.234582118414 18127.267063727606 19511.340683029703 21520.670220952794 19848.223059425185 23726.44920623622 25174.651666059704 23748.904879564976 25032.5828770983 24541.3605680567 0.8134526415826665 0.738641487029951 0.7950390781685459 0.8769143080422497 0.808766205295881 0.9667943690586911 1.0258050525050066 0.9677093824405484 1.020016099257389 1.0 14.582927613488174 -6.804435876964824 3.522182615550589 1.000801290208351 0.803962436867461 0.8829614158814328 0.034662908510058175 0.08045938309624481 2.0584539006142144 0.013527531713958827 0.012282382801499538 1.5687875100881315e-07 6.804435876964824 -0.1968388533408899 KGAANASGSS(ph)PDAPAK ddPTM_A459_Selumetinib_30min_R1 1 KGAANASGSSPDAPAK 16 1 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 KGAANASGS(0.026)S(0.974)PDAPAK 254.89 9.234299999999999e-30 15797000.0 3555.6 3599.0 3438.0 3881.4 3301.4 2839.2 3066.7 3403.3 1561.5 2684.9 True False 3638.4385620067615 3177.627406870292 2971.1384835822123 3203.586352901673 3002.7889529095096 2810.64022578734 2835.3763499856636 3313.0334285236145 2649.751452552327 3029.5330681406836 1.2009898819951754 1.0488835524810753 0.9807248895308115 1.057452181853163 0.9911721989396909 0.9277470034391522 0.9359119990480316 1.0935788961554145 0.8746402144996424 1.0 11.564879737704151 -1.5228792707563723 0.8519787124492205 0.9780759653875973 80.56812572199459 0.5616198155259935 0.05888706468120914 496.93205750624503 1.3671564413905144 0.019701608760186964 76668.74307225642 0.02999996370142343 1.5228792707563723 79.59004975660699 KGAANASGSS(ph)PDAPAK ddPTM_A459_Selumetinib_30min_R2 3 KGAANASGSSPDAPAK 16 1 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 KGAANAS(0.064)GS(0.173)S(0.763)PDAPAK;KGAANAS(0.003)GS(0.018)S(0.978)PDAPAK;KGAANAS(0.011)GS(0.282)S(0.707)PDAPAK 109.5 0.0015195 42760900.0 132217.0 119635.0 129116.0 143726.0 139927.0 114413.0 119968.0 119744.0 90937.0 124325.0 True False 124868.9084465869 128810.61981284457 120808.81713087155 124150.27085882054 122348.11929674845 130172.35221219448 125546.74971208225 120092.43521531379 109126.94099207509 120735.41421485713 1.0342359717619714 1.0668834877529558 1.000607965082091 1.0282838027779193 1.0133573491454744 1.078162137088822 1.0398502421887832 0.9946744788699767 0.9038519617605821 1.0 16.881489385146622 -7.977535615921246 4.27062298343591 0.9501681734831615 1.0368863756006832 0.5592904408603354 0.03044894251416879 0.13713416305707168 5.808550486339682 0.018807001488568575 0.007847798307784332 1.0530873212774166e-08 7.977535615921246 0.08671820211752168 KGAANASGSS(ph)PDAPAKDAR ddPTM_A459_Selumetinib_30min_R1 1 KGAANASGSSPDAPAKDAR 19 2 E7EPJ7;O75962-5;O75962-4;O75962 E7EPJ7 TRIO Triple functional domain protein 1 KGAANASGS(0.09)S(0.91)PDAPAKDAR 181.64 4.191e-13 4809200.0 779.53 696.14 2798.6 2594.9 1778.1 1010.8 539.74 900.08 987.9 562.77 True False 797.6915322986641 614.6356051732943 2418.565491609417 2141.7494273057528 1617.2711689490513 1000.6322697329686 499.02697725283315 876.206954528115 1676.3941466387741 635.0070113440096 1.2561932672370473 0.9679193996179685 3.808722499757062 3.3727965031010947 2.5468556095562676 1.575781451003357 0.7858605784472033 1.379838236232383 2.6399616330072333 1.0 9.31062871106959 -6.802599229540846 6.10728674252625 1.4480808758767774 2.4452903537552264 0.19829690142258372 0.9165031229776668 0.33729986168537646 31.669462743566157 0.3550516663753952 0.31801107482659297 1.5754360189673777e-07 6.802599229540846 0.997209477878449 KGAGDGS(ph)DEEVDGK ddPTM_A459_Selumetinib_30min_R1 15 KGAGDGSDEEVDGK 14 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK 191.36 5.2811e-06 5224477400.0 110252.76000000001 171147.25 93544.76999999999 103127.08 85270.18 105202.35 106430.84 109684.73000000001 71168.84999999999 122083.01 True False 112821.43479347421 151109.25040580225 80841.90403864064 85117.8714130467 77557.5072746731 104144.10987509109 98402.67605083915 106775.53465418465 120768.3404828555 137753.55352271983 0.8190092517276983 1.096953556126446 0.586858937365324 0.6178996420517611 0.5630163817289945 0.7560175923731398 0.7143385672051611 0.7751200017978053 0.8766985489266312 1.0 17.07173000981024 -8.454361530290901 1.7822155974062859 0.9984634978886059 0.7337241394329937 0.25694144646887374 0.1430260534679718 0.5289370156416983 3.661282801984856 0.14855122083450858 0.042655027794833454 3.512679043208611e-09 8.454361530290901 -0.26473935845561214 KGAGDGS(ph)DEEVDGK ddPTM_A459_Selumetinib_30min_R2 22 KGAGDGSDEEVDGK 14 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK;KGAGDGS(1)DEEVDGK 182.91 0.00010881 3980225500.0 1121892.5 883852.0 859203.5 944678.0 910355.6 828786.1 1181614.1 1146253.4 850069.8 831494.3 True False 1059542.2061415124 951640.6063678908 803923.2822400389 816011.2267395552 795988.5908456753 942943.862303856 1236561.4969739208 1149588.8076215333 1020107.5129347275 807486.8990773577 1.3121478594292433 1.1785214193013467 0.9955867806135422 1.0105566141963882 0.9857603779766329 1.1677512828768772 1.531370352121908 1.4236624878187676 1.2633115337231007 1.0 19.62307932769297 -7.01462547899357 23.56938643193875 1.341272711053103 1.089294757520323 0.2677437355134683 0.15773247827829892 358.8622072887934 578316.1382565042 0.059194305648891374 0.047664394303588715 9.668843282097164e-08 7.01462547899357 -0.2519779535327802 KGAGDGS(ph)DEEVDGKADGAEAK ddPTM_A459_Selumetinib_30min_R1 2 KGAGDGSDEEVDGKADGAEAK 21 2 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 KGAGDGS(1)DEEVDGKADGAEAK;KGAGDGS(1)DEEVDGKADGAEAK 103.71 0.00019981 65528000.0 15461.900000000001 17492.8 18232.1 18169.4 12449.7 15991.2 13906.099999999999 15567.6 9868.5 14375.0 True False 15822.132186379898 15444.734843817914 15756.280961756604 14996.455371879127 11323.62683317306 15830.343046847902 12857.151681134652 15154.69667730856 16746.123733277385 16220.17127435745 0.9754602413719999 0.952193079997532 0.9714004060281279 0.9245559198001255 0.698120053212671 0.975966454304596 0.7926643599294533 0.9343117542332426 1.0324258264616117 1.0 13.985501433097332 -10.421191019390514 8.072755579935874 0.999999999555823 0.9123678327507009 0.0625784497008035 0.09400604829877034 1.9760180106945905e-10 0.0 0.09212911126296612 0.022344591584205358 3.791481843625349e-11 10.421191019390514 -0.08763216680512209 KGAGDGS(ph)DEEVDGKADGAEAK ddPTM_A459_Selumetinib_30min_R2 2 KGAGDGSDEEVDGKADGAEAK 21 2 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 KGAGDGS(1)DEEVDGKADGAEAK;KGAGDGS(1)DEEVDGKADGAEAK 104.77 0.00017152 32327000.0 94794.0 78254.0 76655.0 70703.0 66818.0 57416.0 92685.0 78340.0 50782.0 64775.0 True False 89525.72897044824 84255.83017373123 71723.10075565364 61073.12943052198 58423.725479500994 65324.53282944567 96995.0361518432 78567.95643011483 60939.81896763213 62904.77744433826 1.4231944314510248 1.3394186196475395 1.1401852716054568 0.9708822113640411 0.9287645208060333 1.03846695725533 1.5419343346007377 1.2489982418209213 0.9687629691012763 1.0 15.940881969523952 -5.199337302528025 3.3132692103020083 1.1143546025003095 1.4049172256923725 0.2964160062311022 0.1722760961317614 0.36142427942658945 7.78490889557417 0.05043106142989799 0.15827310289967722 6.319208681621818e-06 5.199337302528025 0.29056262319206305 KGAGDGS(ph)DEEVDGKADGAEAKPAE ddPTM_A459_Selumetinib_30min_R1 6 KGAGDGSDEEVDGKADGAEAKPAE 24 3 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE 68.445 0.008387700000000001 9406458000.0 16053.199999999999 18132.0 23827.100000000002 25344.800000000003 16664.7 18367.3 15736.1 16906.7 11353.900000000001 14431.600000000002 True False 16427.208325910382 16009.0970106619 20591.51069289172 20918.806460818858 15157.380827391748 18182.541638174065 14549.113307793214 16458.27939529873 19266.739043953825 16284.036435688144 1.008792162237396 0.9831160151162714 1.2645212858749997 1.284620465167539 0.9308122643457605 1.1165868923214364 0.893458655982084 1.0107002314996492 1.183167276740353 1.0 13.991170734187651 -6.282472618245633 24.882649516057675 1.021246097753086 1.1336276863344181 0.1805292901758736 0.11770662897794366 1463.4633447593628 1731295.2654826932 0.038638814394326856 0.0438535482961701 5.218280038414365e-07 6.282472618245633 0.11238158858133218 KGAGDGS(ph)DEEVDGKADGAEAKPAE ddPTM_A459_Selumetinib_30min_R2 3 KGAGDGSDEEVDGKADGAEAKPAE 24 3 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 1 KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE;KGAGDGS(1)DEEVDGKADGAEAKPAE 61.903 0.0097707 1308372000.0 189715.0 304931.0 154476.0 191945.0 137083.0 95382.0 129091.0 127584.0 74833.0 179950.0 True False 179171.39978931763 328318.2271922979 144537.18234075158 165801.7598764065 119861.40800243091 108520.00470841203 135093.98728896378 127955.24831733173 89801.69100871983 174754.37593374983 1.0252756123099447 1.8787410926795036 0.8270876283838882 0.948770289673677 0.6858850163950738 0.6209859073832431 0.7730506693587949 0.732200539377853 0.5138737758576304 1.0 17.414969056268582 -5.391683087554016 6.794460607843194 0.7464229139723186 1.4481668632666043 0.5833294186593825 0.23348733453121168 0.14456037600494565 7.27511222019646 0.05747232407859358 0.12071858444130447 4.058045502652384e-06 5.391683087554016 0.7017439492942856 KGAGDGSDEEVDGKADGAEAKPAE ddPTM_A459_Selumetinib_30min_R1 1 KGAGDGSDEEVDGKADGAEAKPAE 24 3 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 124.1 6.6893e-06 0.0 1058.9 1364.6 1991.9 1962.0 1078.9 1101.3 1144.7 1199.6 634.44 1062.8 False True 1083.5703097392732 1204.8319976146718 1721.4109207235033 1619.3735313013563 981.3136854952664 1090.2219219003944 1058.3543573967431 1167.7827111500396 1076.598342335766 1199.220732548668 0.9035620218442969 1.004679092775588 1.4354412611471787 1.3503548490691535 0.8182927953636274 0.9091086338904252 0.8825350735451799 0.9737846248439902 0.8977482736207401 1.0 10.227881515094014 -6.271784802670517 24.996749022235992 0.9104918233600624 1.180159434475687 0.42076902942541816 0.1492980423656425 739.810906723937 1787537.1225527632 0.0505154386814534 0.05790986003389595 5.348293071065079e-07 6.271784802670517 0.26966761111562454 KGAILSEEELAAMS(ph)PTAAAVAK ddPTM_A459_Selumetinib_30min_R1 2 KGAILSEEELAAMSPTAAAVAK 22 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 KGAILSEEELAAMS(0.976)PT(0.024)AAAVAK;KGAILSEEELAAMS(0.834)PT(0.166)AAAVAK 115.45 1.7243e-05 65907000.0 9157.4 9013.0 13351.5 15469.2 11385.3 9105.4 8942.6 8249.6 5193.5 7055.4 True False 9370.74960280142 7957.753769969979 11538.439634539824 12767.794612847569 10355.501625237972 9013.80794304172 8268.052482271436 8030.79380952264 8812.990181767864 7961.029315415762 1.1770776405327223 0.999588552520534 1.4493652990570898 1.6037869108362623 1.3007742108404936 1.132241521280088 1.0385657626283518 1.0087632504972424 1.1070164211934708 1.0 12.958739259682451 -6.890170628656272 3.2606775498409415 1.043065159354603 1.3140333236295427 0.41501064621276806 0.15077360265523124 0.28620966552229654 6.028279821814706 0.06449995676104513 0.056062074500593854 1.287743514605247e-07 6.890170628656272 0.27096816427493975 KGAILSEEELAAMSPT(ph)AAAVAK ddPTM_A459_Selumetinib_30min_R2 1 KGAILSEEELAAMSPTAAAVAK 22 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 KGAILSEEELAAMS(0.456)PT(0.544)AAAVAK 89.039 0.0030807 0.0 18535.0 19180.0 18104.0 21774.0 18043.0 10019.0 12445.0 9979.9 9302.3 16824.0 True False 17504.898901483823 20651.04432657968 16939.20835014482 18808.34363775493 15776.277033533428 11399.026306573352 13023.717159299676 10008.93985673862 11163.019927978503 16338.247405998409 1.0714061592100197 1.263969372810322 1.0367824607629443 1.1511848958077138 0.9656039991009893 0.6976896617680257 0.7971306123396174 0.6126079259311465 0.6832446376029366 1.0 13.995965614300912 -6.555495687736864 2.8706335115597157 0.7353605619018132 1.1330844521539813 0.7080489951879123 0.11220441053287622 0.1322624082964908 2.222728195543074 0.03742575928209355 0.03910154549440625 2.7829430065383883e-07 6.555495687736864 0.39772389025216814 KGCT(ph)WGPNSIQMK ddPTM_A459_Selumetinib_30min_R2 1 KGCTWGPNSIQMK 13 1 Q5TCX8;Q5TCX8-3 Q5TCX8 MLK4 Mitogen-activated protein kinase kinase kinase MLK4 1 KGCT(1)WGPNSIQMK 98.507 0.0156 7945900.0 38029.0 37580.0 38596.0 40959.0 32556.0 28050.0 27596.0 35749.0 18165.0 31095.0 True False 35915.50042214882 40462.265161254676 36112.77538014744 35380.313541783944 28466.024225667246 31913.63288745209 28879.26868043663 35853.023671434436 21798.507572506744 30197.206555487413 1.1893649949426293 1.3399340461146696 1.1958978826001723 1.171641935712582 0.9426707789464195 1.0568405666534333 0.9563556359880816 1.1872960369878733 0.7218716583089217 1.0 14.882127476287065 -6.0457482245912315 2.341290246311482 0.9887583612112628 1.2551665329161723 0.5206258778333177 0.11628154319234203 0.23731701801157892 2.586244069535445 0.03468526525627834 0.051535874759749876 9.000192023196483e-07 6.0457482245912315 0.2664081717049095 KGDEPQASGYHS(ph)EGETLK ddPTM_A459_Selumetinib_30min_R2 1 KGDEPQASGYHSEGETLK 18 1 Q70EL1;Q70EL1-7;H7C1E9;Q70EL1-6;H7C296 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 KGDEPQAS(0.003)GY(0.004)HS(0.581)EGET(0.412)LK 79.17699999999998 0.0063228 3554200.0 23486.0 21136.0 29224.0 31126.0 38128.0 22800.0 28261.0 29510.0 29871.0 29970.0 True False 22180.74214190715 22757.06323704841 27343.759656685368 26886.58510465509 33338.01977135522 25940.493042207065 29575.192498109136 29595.869214356524 35846.03466547477 29104.688228588468 0.7621020355105478 0.7819036939449151 0.9394967381862073 0.9237888031470264 1.1454518773579752 0.8912822854679017 1.0161659271463526 1.0168763527686782 1.2316240732056536 1.0 14.82896394297007 -4.812844798238609 0.547754008515105 1.062984441527741 0.5164393641280471 0.5847253277472408 0.08936660158200323 2.8642386441539194 0.6718473440380812 0.05116061423805642 1.001087158480353 1.5387044215698618e-05 4.812844798238609 -0.5465450773996938 KGDRS(ph)PEPGQTWTR ddPTM_A459_Selumetinib_30min_R1 5 KGDRSPEPGQTWTR 14 2 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 KGDRS(1)PEPGQTWTR;KGDRS(0.94)PEPGQT(0.059)WT(0.001)R;KGDRS(0.97)PEPGQT(0.03)WTR;KGDRS(0.998)PEPGQT(0.001)WTR;KGDRS(0.983)PEPGQT(0.013)WT(0.004)R 139.0 0.0083082 1026287000.0 11250.630000000001 12089.0 13801.800000000001 15146.8 12543.199999999999 10423.76 11139.199999999999 10902.5 6023.97 7909.58 True False 11512.747789084859 10673.614259976372 11927.59136786067 12501.695720650037 11408.669774681828 10318.906438416829 10298.961175778626 10613.330283688976 10222.2371166389 8924.85163883354 1.2899651730893704 1.195943046664627 1.33644701901393 1.4007735059990292 1.2783035770634859 1.156199212714923 1.1539644122448045 1.1891884272348663 1.1453677361044543 1.0 13.123612471540728 -6.747749074218387 4.018614018559575 1.1402563134563155 1.30440089160129 0.6220926079333009 0.06682690636492222 0.16256370249389604 5.848716394792253 0.024283945904546633 0.02292528028252499 1.7875200662527674e-07 6.747749074218387 0.1641445781449744 KGDRS(ph)PEPGQTWTR ddPTM_A459_Selumetinib_30min_R2 2 KGDRSPEPGQTWTR 14 2 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 KGDRS(1)PEPGQTWTR;KGDRS(1)PEPGQTWTR 102.33 0.0029991 704100000.0 149484.0 158272.0 148657.0 169100.0 131687.0 126609.0 157618.0 120773.0 112512.0 137248.0 True False 141176.27771186436 170410.95347530858 139092.5704655036 146068.28828622928 115143.30176328303 144048.24050792944 164947.5493141418 121124.42943495349 135017.5438479424 133285.29362687084 1.0592037116044035 1.278542807223505 1.0435702745637498 1.0959070150315617 0.8638860194555604 1.080751196086113 1.237552507299933 0.9087606452219597 1.0129965592897365 1.0 17.024158080204693 -5.406844855796471 8.754383338157675 1.0318874361242967 1.168661059463251 0.2074238897827928 0.1084462141087503 0.4820220477845595 33.468279976324034 0.02857647602881645 0.059622871571101396 3.9188184512721e-06 5.406844855796471 0.13677362333895426 KGDRSPEPGQT(ph)WTR ddPTM_A459_Selumetinib_30min_R1 1 KGDRSPEPGQTWTR 14 2 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 KGDRS(0.112)PEPGQT(0.886)WT(0.002)R 106.28 0.018113 757550000.0 5197.3 5655.9 6805.2 6465.5 5547.8 4445.6 4957.0 4540.1 2322.2 3218.4 True False 5318.38697781464 4993.704598643424 5881.091218287858 5336.421797466321 5046.002469543645 4400.8813002818415 4583.089499096406 4419.681799676803 3940.6037932225518 3631.51298987075 1.4645099694394672 1.3751030527970536 1.6194603281584774 1.4694761693957896 1.3895041773548051 1.2118588898227993 1.2620330732341738 1.2170359329580989 1.0851135061925807 1.0 11.826355025229137 -7.378798198104694 0.5722294265018381 1.0163447540831432 1.5048541369757917 0.8351620677817798 0.07295358514308871 0.34594759094516164 0.23431959755252463 0.07317844943890332 0.05301569601578847 4.180245633415673e-08 7.378798198104694 0.48850938289264856 KGDS(ph)SAEELK ddPTM_A459_Selumetinib_30min_R1 4 KGDSSAEELK 10 1 P26373-2;P26373 P26373-2 RPL13 60S ribosomal protein L13 1 KGDS(0.5)S(0.5)AEELK;KGDS(0.5)S(0.5)AEELK;KGDS(0.5)S(0.5)AEELK;KGDS(0.5)S(0.5)AEELK 129.37 0.0053157 38933500.0 12184.8 13412.0 10952.400000000001 10624.7 10137.0 13244.899999999998 11206.8 12784.9 9134.800000000001 11709.900000000001 True False 12468.682132506467 11841.716804930353 9465.124237226817 8769.29559531984 9220.11013983271 13111.668331406998 10361.462053353554 12445.802920792044 15501.088420605196 13212.979729085097 0.9436692092291459 0.8962184948232192 0.7163504698634854 0.6636879625279687 0.6978070298206033 0.992332433731425 0.7841881442189279 0.9419376382903015 1.1731712859956482 1.0 13.689668232630078 -7.992869656176059 3.7816484433772373 1.0846477040653795 0.8102971566846618 0.5031499282016709 0.10852767225655544 0.19096606998369278 5.946559702916299 0.07857198204022112 0.030911512413500354 1.0165537430749574e-08 7.992869656176059 -0.2743505473807176 KGDS(ph)SAEELK ddPTM_A459_Selumetinib_30min_R2 1 KGDSSAEELK 10 1 P26373-2;P26373 P26373-2 RPL13 60S ribosomal protein L13 1 KGDS(0.863)S(0.137)AEELK 86.262 0.018125 20019000.0 48711.0 39543.0 37284.0 35882.0 39301.0 28994.0 53165.0 53625.0 31710.0 48900.0 True False 46003.837625582855 42575.82094921483 34885.18803174985 30994.809700097467 34363.657024602166 32987.66031867331 55637.27784444892 53781.039871903326 38052.88605142797 47488.12994254174 0.9687439299303888 0.8965571186047849 0.7346085869028572 0.6526854129147565 0.7236262423089828 0.6946506497220828 1.171603891578111 1.1325154293709963 0.8013136355857782 1.0 15.535279324296091 -7.254018693378969 24.869446244035903 1.0374011940938053 0.7736405954921194 0.4750508288729005 0.12738193934628297 480.6022961535833 1610677.994363776 0.052523291769157855 0.039853136679902916 5.571617664485313e-08 7.254018693378969 -0.2637605986016859 KGDSS(ph)AEELK ddPTM_A459_Selumetinib_30min_R2 1 KGDSSAEELK 10 1 P26373-2;P26373 P26373-2 RPL13 60S ribosomal protein L13 1 KGDS(0.211)S(0.789)AEELK 82.925 0.021263 19100000.0 49298.0 41681.0 34355.0 40113.0 38150.0 30055.0 49181.0 56568.0 36400.0 46487.0 True False 46558.21451553003 44877.79867446133 32144.636702895797 34649.54020121535 33357.25593467275 34194.803437874274 51468.01395030271 56732.603514663475 43681.01710097693 45144.799522268666 1.0313084786779076 0.9940856787352521 0.7120341001191012 0.7675200813356963 0.7388947628002767 0.757447232011894 1.1400651790449303 1.2566808162849161 0.9675758351619285 1.0 15.462272184851253 -7.266750876313325 24.89655654162706 1.1124705418037104 0.8280184354708009 0.5048471976127125 0.12415437707311273 352.1429780312223 1650589.1824133385 0.05439091139294374 0.03791409807991392 5.4106460401434764e-08 7.266750876313325 -0.2844521063329095 KGDSSAEELK ddPTM_A459_Selumetinib_30min_R2 1 KGDSSAEELK 10 1 P26373-2;P26373 P26373-2 RPL13 60S ribosomal protein L13 0 121.68 0.006360899999999999 4746500.0 20465.0 23249.0 18043.0 23210.0 16818.0 23834.0 45040.0 75190.0 30097.0 53852.0 False True 19327.637227885964 25032.123542682526 16882.133023733048 20048.757960516767 14705.172485172377 27116.917156489606 47134.44924506685 75408.7904516254 36117.24098044236 52297.15283570057 0.36957341231570795 0.47865174651715237 0.32281170404765297 0.3833623222951157 0.2811849534404082 0.5185161272867284 0.901281364076298 1.4419291751605205 0.6906158179186187 1.0 15.674444784881587 -7.261773688762517 3.04617375446971 1.0661024806665305 0.3753889382830639 0.7447498708784251 0.17881230801557818 0.11920196530767034 2.2593368844479147 0.07465111495419753 0.05104328453422406 5.4730108767753326e-08 7.261773688762517 -0.6907135423834665 down KGDVEGSQS(ph)QDEGEGSGESER ddPTM_A459_Selumetinib_30min_R1 4 KGDVEGSQSQDEGEGSGESER 21 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 KGDVEGSQS(1)QDEGEGSGESER;KGDVEGSQS(0.999)QDEGEGSGESER;KGDVEGSQS(1)QDEGEGSGESER;KGDVEGSQS(1)QDEGEGSGESER 182.72 7.5742e-15 66468000.0 9898.9 9447.900000000001 10586.3 11373.400000000001 9608.400000000001 9062.0 9487.7 9188.900000000001 5542.030000000001 7456.070000000001 True False 10129.525110093578 8341.73547579045 9148.738606383464 9387.249195159455 8739.321916500807 8970.844507637677 8772.035150408905 8945.18052224624 9404.420136143824 8413.129212772055 1.2040139707727116 0.9915140092139294 1.0874358844381793 1.1157856913582853 1.0387718642468435 1.066291064924921 1.042660219350012 1.0632405964556533 1.11782666096069 1.0 13.038426786697027 -4.742512049913273 24.999670690429674 1.0620238576902423 1.2040144377093636 0.5367917066092596 0.04050180105721944 1022.2357161621122 1350123.2832747926 0.009698911434864052 0.3421058108685881 1.8092057114249876e-05 4.742512049913273 0.14199058001912124 KGDVEGSQS(ph)QDEGEGSGESER ddPTM_A459_Selumetinib_30min_R2 4 KGDVEGSQSQDEGEGSGESER 21 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 KGDVEGS(0.001)QS(0.937)QDEGEGS(0.055)GES(0.006)ER;KGDVEGS(0.001)QS(0.998)QDEGEGS(0.001)GESER;KGDVEGSQS(1)QDEGEGSGESER;KGDVEGS(0.004)QS(0.992)QDEGEGS(0.003)GESER 172.52 6.166699999999999e-11 113184100.0 153166.0 144252.0 164396.0 180191.0 172900.0 142655.0 150343.0 154767.0 120400.2 162925.0 True False 144653.64689207813 155315.66455671415 153818.94034083103 155648.6749531873 151178.7562543882 162304.43135684403 157334.24739900263 155217.3463469437 144483.60426266608 158220.93192001263 0.9142510105123554 0.9816379076520215 0.9721781971211811 0.9837426253555015 0.9554915043150892 1.0258088445522227 0.9943959088709056 0.9810165094047899 0.9131762941183322 1.0 17.271580948960256 -4.760141317609147 24.932812064406278 0.9792180337131092 0.9142509301142642 0.3221272069645511 0.027993826283890834 38.93717188217743 747595.8067125576 0.0069433161752699936 0.042064572194969944 1.7372354476146792e-05 4.760141317609147 -0.06496710359884506 KGDVEGSQSQDEGEGS(ph)GESER ddPTM_A459_Selumetinib_30min_R1 1 KGDVEGSQSQDEGEGSGESER 21 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 KGDVEGSQS(0.004)QDEGEGS(0.888)GES(0.108)ER 133.98 2.1305e-05 2842300.0 627.71 783.59 771.49 780.91 758.92 561.9 686.64 690.16 475.62 506.55 True False 642.3344216889594 691.8469185188923 666.7258954912276 644.538727996199 690.2758199982082 556.2477961643797 634.8461919829647 671.854714844374 807.0924020896181 571.5706267148361 1.1238058634693073 1.2104311981449383 1.1664803338885812 1.1276624407743885 1.2076824590613466 0.973191710990248 1.110704718385918 1.1754535370474364 1.4120606699621163 1.0 9.15878796733214 -11.06035935896669 3.442767603763857 0.9958725561109812 1.1615889762890081 0.1874020077780313 0.10398254825286873 10915894.19946748 17550373.197301526 280256.5999149171 0.025557302119488503 8.7024320521131e-12 11.06035935896669 0.1657164201780269 KGDVEGSQSQDEGEGS(ph)GESER ddPTM_A459_Selumetinib_30min_R2 1 KGDVEGSQSQDEGEGSGESER 21 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 KGDVEGS(0.002)QS(0.002)QDEGEGS(0.881)GES(0.116)ER 57.145 0.014500999999999997 2759600.0 4941.4 4857.1 6477.0 6165.4 7351.4 4779.5 5929.5 4843.6 4982.7 5195.6 True False 4666.776769991484 5229.623951961951 6060.276871624389 5325.661884091772 6427.851409650149 5437.832741018798 6205.233499081352 4857.694074098853 5979.379228270263 5045.589528210019 0.9249220024537106 1.0364743153843552 1.201103823000509 1.0555083512671535 1.2739544851422948 1.0777398182344673 1.2298331967726932 0.9627604558276812 1.185070484794572 1.0 12.300807128767998 -4.943921229808584 3.527446767223214 1.1271487761370074 0.9278225830094027 0.29230712818090787 0.09602591499533646 0.28333243441906053 6.782405613698662 0.022783563837656052 0.11985717359692818 1.1378336417637002e-05 4.943921229808584 -0.1993261931276047 KGDVVHCWYTGTLQDGTVFDTNIQT(ph)SAK ddPTM_A459_Selumetinib_30min_R1 2 KGDVVHCWYTGTLQDGTVFDTNIQTSAK 28 1 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 1 KGDVVHCWYTGTLQDGT(0.004)VFDT(0.098)NIQT(0.717)S(0.181)AK;KGDVVHCWYTGTLQDGTVFDTNIQT(0.805)S(0.195)AK 117.01 2.314e-12 78873000.0 3715.4 5078.4 5587.9 5150.1 3961.4 4158.8 3871.1 4026.7 2839.9 3404.1 True False 3801.9615910900916 4483.818567115889 4829.093872137593 4250.731714350209 3603.0920694419765 4116.966247888278 3579.099810359508 3919.898835435028 4819.102881910568 3841.0493937419237 0.9898236657108559 1.167342074387589 1.257232953058467 1.1066589566059122 0.93804887677632 1.0718337167431107 0.9318025996205099 1.0205280988631833 1.2546318435170736 1.0 11.907284800899808 -6.010248214235532 24.78172096496904 1.0327003420733236 1.1478691705896413 0.16639627385867972 0.10414401329364463 727.1846785859487 1758449.9087495941 0.030292162106214025 0.041987824209381366 9.766788558460696e-07 6.010248214235532 0.11516882851631771 KGEMPVSGLAVGSTLPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 KGEMPVSGLAVGSTLPSPR 19 1 Q3T8J9-3 Q3T8J9-3 GON4L GON-4-like protein 1 KGEMPVSGLAVGS(0.001)T(0.001)LPS(0.998)PR 105.17 0.00044903 3720900.0 56456.0 57433.0 63042.0 66114.0 66926.0 54795.0 54700.0 62461.0 48534.0 61961.0 True False 53318.40153127438 61837.92642379824 58985.946354939784 57109.15914698863 58518.15755396879 62342.51387051474 57243.65838599371 62642.751169024785 58242.156153264106 60172.02493598834 0.8860995053431404 1.027685647767083 0.9802885380322448 0.9490981765653056 0.9725143472605592 1.0360713959158827 0.9513334219164162 1.0410610451561972 0.9679274748560108 1.0 15.876805287355149 -6.548419633494936 24.650604222528752 0.9994533591777307 0.9661938790127619 0.1603032274887185 0.04131471587802335 392.8332165070466 379137.0696834764 0.012923937593154128 0.012924358835838359 2.828657507717157e-07 6.548419633494936 -0.033259480164968824 KGES(ph)PSLESR ddPTM_A459_Selumetinib_30min_R1 2 KGESPSLESR 10 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;Q8NDX5-3 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 KGES(0.765)PS(0.227)LES(0.008)R;KGES(0.963)PS(0.035)LES(0.001)R 115.92 0.011666 32896000.0 7062.700000000001 9270.3 6670.1 7600.6 7816.8 6548.8 8690.5 7481.9 3918.7000000000003 7107.0 True False 7227.247168378095 8184.92896635445 5764.337056236681 6273.297890932254 7109.771820168127 6482.92501783465 8034.9685882383055 7283.455707363684 6649.747689476025 8019.252678042318 0.9012369928393914 1.0206598164397256 0.7188122494281957 0.7822796141726898 0.8865878287680773 0.808420095751027 1.001959772416078 0.9082461919807896 0.8292228660762663 1.0 12.969252081452256 -7.2463185735199325 24.873171953631992 0.9272110653319174 0.8528331528971939 0.16993948171782747 0.08798123728270985 1611.6642721165686 2651133.032765979 0.035353467877713186 0.027274393698998683 5.6712843989773655e-08 7.2463185735199325 -0.07437791243472358 KGESQTDIEITR ddPTM_A459_Selumetinib_30min_R2 1 KGESQTDIEITR 12 1 B4DUR8;P49368-2;P49368 B4DUR8 CCT3 T-complex protein 1 subunit gamma 0 84.352 0.044307 4898500.0 16456.0 13017.0 13820.0 18940.0 14806.0 9435.7 15052.0 12454.0 10825.0 16446.0 False True 15541.441398587409 14015.362043748057 12930.836246078288 16360.3393266776 12945.937912680594 10735.382026243562 15751.947824972176 12490.239078129312 12990.302475771294 15971.161248160348 0.9730940134598893 0.8775418284229287 0.8096365721414113 1.0243675505162206 0.810582130599413 0.6721729158848814 0.9862744217667064 0.7820495256453572 0.8133599225458695 1.0 13.963181593116063 -4.786982074209059 3.8497411692202888 0.8554023302573782 0.9838917529102619 0.08604307693473179 0.10557176037805349 0.58573309076708 15.66884579552099 0.026038937882296113 0.21041543683683167 1.633119354580783e-05 4.786982074209059 0.12848942265288366 KGFNGCDS(ph)PEPDGEDSLEQSPLLEDK ddPTM_A459_Selumetinib_30min_R2 2 KGFNGCDSPEPDGEDSLEQSPLLEDK 26 1 Q14814-4;Q14814;Q05BX2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 KGFNGCDS(0.991)PEPDGEDS(0.009)LEQSPLLEDK;KGFNGCDS(0.991)PEPDGEDS(0.009)LEQSPLLEDK 98.135 0.00026344 5669800.0 36406.0 27602.0 34692.0 34539.0 33155.0 28964.0 32085.0 32530.0 26955.0 33349.0 True False 34382.70026476503 29718.984645581473 32459.954489793647 29834.728616901688 28989.772490539297 32953.528090986205 33577.01607522136 32624.656914368577 32346.753185627254 32386.127718892127 1.0616490048826746 0.9176455087048025 1.0022795800579287 0.9212193836775953 0.8951293202499291 1.0175198584103369 1.0367715574602192 1.0073651656519995 0.9987842160814457 1.0 14.98308836065825 KGGEFDEFVNDDT(ph)DDDLPISK ddPTM_A459_Selumetinib_30min_R1 5 KGGEFDEFVNDDTDDDLPISK 21 1 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 1 KGGEFDEFVNDDT(0.993)DDDLPIS(0.007)K;KGGEFDEFVNDDT(0.999)DDDLPIS(0.001)K;KGGEFDEFVNDDT(1)DDDLPISK;KGGEFDEFVNDDT(1)DDDLPISK;KGGEFDEFVNDDT(1)DDDLPISK 177.1 5.4964e-14 72664900.0 53921.72 57576.06 63990.68 66436.11 57970.7 52415.79 57359.43 54149.78 32803.600000000006 49000.149999999994 True False 55177.99116259735 50835.02812881589 55301.09713164473 54834.29054873873 52727.26042055837 51888.53474232949 53032.762014757966 52713.5519311255 55665.31331984987 55289.796554379514 0.9979778295680253 0.919428742676197 1.0002043881144345 0.9917614816109375 0.9536526394829324 0.9384830108986789 0.9591781001146988 0.9534047006174062 1.006791791413105 1.0 15.754725642674794 -8.267432145092489 24.565372022562553 1.0033959043685432 0.9634993679018083 0.28475051541967955 0.02478589583617252 535.6560473727822 2195704.0084787295 0.021630259352916542 0.0062038631240820576 5.402165125167245e-09 8.267432145092489 -0.039896536466734855 KGGEFDEFVNDDT(ph)DDDLPISK ddPTM_A459_Selumetinib_30min_R2 6 KGGEFDEFVNDDTDDDLPISK 21 1 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 1 KGGEFDEFVNDDT(1)DDDLPISK;KGGEFDEFVNDDT(1)DDDLPISK;KGGEFDEFVNDDT(1)DDDLPISK;KGGEFDEFVNDDT(1)DDDLPISK;KGGEFDEFVNDDT(0.991)DDDLPIS(0.009)K;KGGEFDEFVNDDT(1)DDDLPISK 149.73 2.5471e-06 47691700.0 867295.0 828508.0 907397.0 969787.0 950502.0 745677.0 765207.0 834369.0 633979.0 888225.0 True False 819094.2159569681 892051.8995268968 849016.0649191554 837700.3376241123 831091.4411643072 848387.2381681504 800790.6417289056 836796.875652777 760792.5148533033 862579.636364298 0.949586776021496 1.0341675851366279 0.9842755719317559 0.9711570993664422 0.9634953181451037 0.9835465647485403 0.9283671999308633 0.9701097039338962 0.8819968415437918 1.0 19.718298132008158 -6.668888432926741 0.934018442978138 0.9430122767473491 0.9916480105954297 0.17411586600255713 0.03546824403369495 0.8386608598831655 1.5921736046205042 0.019459137941787705 0.019744038153827796 2.1434411647438589e-07 6.668888432926741 0.04863573384808062 KGGS(ph)GMK ddPTM_A459_Selumetinib_30min_R1 1 KGGSGMK 7 1 A0A0J9YVW5;A0A0G2JMG3;O95255-3;O95255 A0A0J9YVW5 ABCC6 Multidrug resistance-associated protein 6 1 KGGS(1)GMK 71.223 0.046153 14337000.0 15431.0 15424.0 11372.0 10503.0 4462.9 14037.0 10738.0 8125.5 6945.9 7425.1 True False 15790.512276500822 13618.15090957693 9827.744861924635 8668.848215727903 4059.231482988992 13895.800524576254 9928.024014786599 7909.985344656259 11786.684991535842 8378.183911598717 1.8847177912435789 1.6254299324611423 1.1730161292257089 1.0346929963815656 0.48450016445323096 1.658569526665436 1.1849852091504331 0.9441169384818248 1.406830539398689 1.0 13.032421838171759 -5.1479075787686925 2.4736629537692307 1.0993125990845152 1.8705062414273221 0.4562736575789411 0.28869459466630915 0.2907496686486343 3.2410090038717123 0.07902717129093248 0.33115633588588556 7.113648815061275e-06 5.1479075787686925 0.771193642342807 KGGSGAATT(ph)TR ddPTM_A459_Selumetinib_30min_R1 1 KGGSGAATTTR 11 1 P55318 P55318 FOXA3 Hepatocyte nuclear factor 3-gamma 1 KGGSGAAT(0.172)T(0.656)T(0.172)R 95.483 0.011759 8797600.0 2789.1 3393.2 3452.1 3784.2 3259.1 3027.4 3048.5 2742.7 2035.1 2618.8 True False 2854.0806033561316 2995.9225665441168 2983.3237810279684 3123.3605082316963 2964.314980440837 2996.9471046592703 2818.5491906385687 2669.9546864548274 3453.4160621769092 2954.9484892721575 0.9658647565999126 1.0138662577099784 1.009602634989688 1.0569932164878517 1.0031697646177875 1.0142129771600377 0.9538403802540782 0.9035537154532505 1.1686890904238845 1.0 11.528917266192025 KGLPLGSAVSSPVLFS(ph)PVGR ddPTM_A459_Selumetinib_30min_R1 1 KGLPLGSAVSSPVLFSPVGR 20 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 KGLPLGSAVSS(0.003)PVLFS(0.997)PVGR 149.09 8.8896e-06 25133000.0 3055.6 3222.4 4350.7 4883.8 3673.2 3552.2 2836.8 3045.7 1966.1 3051.5 True False 3126.789534837399 2845.1199099468827 3759.8988366844455 4030.9360102801015 3340.95970855613 3516.4680931395437 2622.8178920792166 2964.918142172118 3336.3281017375175 3443.189749127077 0.9081084002501192 0.8263035491053556 1.0919813053107692 1.1706981909149883 0.9703094955493334 1.021282110296432 0.7617407355328464 0.8610963548912136 0.9689643455122823 1.0 11.74952997256426 -7.208257372165034 24.989607529442726 0.8863745950252063 1.0011519359077854 0.1714727290774546 0.1065297432824078 554.9531114160811 260766.08812930825 0.04383670687541718 0.03395573935483817 6.190740898474302e-08 7.208257372165034 0.11477734088257907 KGLPLGSAVSSPVLFS(ph)PVGR ddPTM_A459_Selumetinib_30min_R2 1 KGLPLGSAVSSPVLFSPVGR 20 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 KGLPLGSAVS(0.001)S(0.01)PVLFS(0.989)PVGR 77.51 0.0026992 4101600.0 24638.0 26403.0 26615.0 28294.0 31502.0 17916.0 18637.0 19712.0 16229.0 22978.0 True False 23268.718593728536 28428.025200974113 24902.619876220975 24440.30839012757 27544.437128546793 20383.76637474481 19503.6574285149 19769.358656502736 19475.253476147103 22314.56543598618 1.0427592085752033 1.2739672337570553 1.115980499268926 1.095262574583382 1.2343703133078505 0.9134735979161119 0.8740325902588184 0.8859396663231072 0.872759701819683 1.0 14.44569809071227 -6.775373207930429 24.18485022892155 0.8999116703922811 1.1540127442577215 0.7470543426409331 0.07065803629900011 73.21409817702549 127076.11038930505 0.023611993185390635 0.02093821117990269 1.6773619693083816e-07 6.775373207930429 0.25410107386544034 KGLVGPELHDR ddPTM_A459_Selumetinib_30min_R1 1 KGLVGPELHDR 11 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 81.92 0.027647 6555200.0 6280.4 6808.0 8481.7 8784.2 8516.5 7489.2 6854.2 6837.7 4187.7 5820.6 False True 6426.72110046891 6010.916195046669 7329.93172664318 7250.204369855948 7746.184078710197 7413.8654476495385 6337.182175651925 6656.34198402019 7106.221042493359 6567.730707445214 0.9785299347282228 0.9152196493429097 1.116052416450926 1.1039131616095463 1.1794308298799587 1.1288321305934699 0.9648967745385879 1.013491916846488 1.081990318884072 1.0 12.681179259067987 -5.259465858873062 24.997038164326142 1.077013838760666 0.9468747851075805 0.39023187375428026 0.06323545554422165 181.478175801371 2298600.976229289 0.01790247014490972 0.04285248279895474 5.502171729506485e-06 5.259465858873062 -0.13013905365308553 KGLVGPELHDR ddPTM_A459_Selumetinib_30min_R2 1 KGLVGPELHDR 11 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 78.692 0.031782 4895900.0 73759.0 67128.0 73183.0 69450.0 82595.0 59914.0 47933.0 54274.0 51951.0 68944.0 False True 69659.77006067144 72276.50174945992 68474.48545562584 59990.79019206757 72218.67769133144 68166.60965485933 50161.97947743763 54431.92835445563 62342.65163222119 66953.40758197545 1.0404215793704361 1.0795044548101163 1.0227184534526943 0.8960080204822571 1.078640808578852 1.0181200945059963 0.7492072665012759 0.812982196429824 0.9311348575633136 1.0 16.030869862679516 -7.215549752868241 15.857642271050015 0.8577492286504496 1.0219656525083665 0.4578162919402904 0.07883543902666043 5.939776451256206 2052.054958979885 0.030150915889391415 0.02335108304368091 6.087658014267853e-08 7.215549752868241 0.1642164238579169 KGNAEGS(ph)SDEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R1 1 KGNAEGSSDEEGKLVIDEPAK 21 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 KGNAEGS(0.5)S(0.5)DEEGKLVIDEPAK 81.878 0.0019029 31396000.0 3036.6 4152.4 2110.8 2199.2 2173.8 2766.5 3775.9 3296.4 1891.0 3730.5 True False 3107.346871804963 3666.235077601613 1824.1649537944538 1815.1510040968099 1977.1801738155602 2738.671521781024 3491.08082300547 3208.9687637837524 3208.888886824497 4209.346013147161 0.7382018161727986 0.8709749842732729 0.4333606569992088 0.4312192436610108 0.46971196182024033 0.6506168685651545 0.8293641843891392 0.7623437830392408 0.7623248069420024 1.0 12.039380390428931 -7.1600053456498705 3.9051905633646307 0.8192478625918095 0.5850991370898152 0.4028233726579852 0.14327364165289236 0.2938157289765061 8.032196538317667 0.06369217891401109 0.048096777848401925 6.918224553528091e-08 7.1600053456498705 -0.23414872550199428 KGNAEGS(ph)SDEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R2 2 KGNAEGSSDEEGKLVIDEPAK 21 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 KGNAEGS(0.5)S(0.5)DEEGKLVIDEPAK;KGNAEGS(0.5)S(0.5)DEEGKLVIDEPAK 51.942 0.01955 54240600.0 123942.0 95408.0 94914.0 104464.0 98844.0 78512.0 120988.0 112835.0 88520.0 87445.0 True False 117053.79981913722 102725.48681492767 88807.33657454977 90235.8229895486 86426.33304342837 89326.31533902459 126614.18173317375 113163.33116916023 106226.47345545255 84920.23564060443 1.3783970208764729 1.2096702987221777 1.04577355331886 1.0625950612223989 1.017735435982514 1.051884920775154 1.4909777484488451 1.3325838101543306 1.2508970642170545 1.0 16.373820754055338 -7.230045447308616 24.99873063694909 1.296330084913034 1.1197246869271817 0.16255476864307483 0.150935736268769 1005.0336643731372 800301.0501103479 0.05870548228872075 0.045468179068521374 5.887820382725793e-08 7.230045447308616 -0.17660539798585217 KGNS(ph)PNSEPPTPK ddPTM_A459_Selumetinib_30min_R1 3 KGNSPNSEPPTPK 13 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 KGNS(0.906)PNS(0.094)EPPTPK;KGNS(1)PNSEPPTPK;KGNS(1)PNSEPPTPK 154.47 0.00019708 38964000.0 13022.099999999999 15833.6 16587.4 18698.9 14852.1 14595.2 15279.199999999999 14757.0 7905.6 12236.1 True False 13325.489593404276 13979.794751159057 14334.9221880662 15433.488136825135 13508.73017735123 14448.385539381303 14126.677642645498 14365.596422508443 13415.225797821127 13806.722624707138 0.965145020698707 1.0125353518830174 1.038256694055246 1.1178241611957134 0.9784168585510185 1.0464746726732896 1.0231738571589613 1.0404783823788275 0.9716444780178732 1.0 13.753083279578211 -9.595656537062581 10.347762322164902 1.000015324684345 1.0246767178745424 0.017776825230424453 0.04269870372228196 0.0 0.0 0.04102619031091692 0.009950312709917785 2.5371343366717804e-10 9.595656537062581 0.024661393190197334 KGNS(ph)PNSEPPTPK ddPTM_A459_Selumetinib_30min_R2 3 KGNSPNSEPPTPK 13 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 KGNS(1)PNSEPPTPK;KGNS(0.999)PNS(0.001)EPPTPK;KGNS(0.759)PNS(0.241)EPPTPK 109.1 0.006285100000000001 19918000.0 81299.0 78502.0 78851.0 85174.0 78856.0 63803.0 61827.0 77176.0 56829.0 78100.0 True False 76780.72704568297 84522.85097628547 73777.81250647746 73573.15426665459 68949.4042984156 72591.28410403243 64702.07800787628 77400.56938282533 68196.3879349291 75845.0500718306 1.0123366913591094 1.1144148615662641 0.9727439356504437 0.9700455625907772 0.9090824547299482 0.9570998243825191 0.8530824087610049 1.0205091737631071 0.8991541026123961 1.0 16.21076740748584 -5.444053288109633 4.21880763350986 0.9417703802529783 1.062854328023639 0.44977867779923664 0.05174646452058182 0.17848167270557058 5.833743496584972 0.013009142181024037 0.028068605209029027 3.59705196473918e-06 5.444053288109633 0.12108394777066078 KGNSPNS(ph)EPPTPK ddPTM_A459_Selumetinib_30min_R2 2 KGNSPNSEPPTPK 13 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 KGNSPNS(0.989)EPPT(0.011)PK;KGNS(0.022)PNS(0.978)EPPTPK 81.65100000000002 0.017777 21205800.0 50493.0 38751.0 43033.0 49972.0 47937.0 38730.0 38526.0 38582.0 35170.0 46847.0 True False 47686.801199494046 41723.07709589623 40264.303630787756 43165.72739349173 41914.72549778259 44064.705944064866 40317.53533782074 38694.267232406055 42204.98273190545 45494.405386876315 1.0481904487809872 0.9171034710991521 0.8850385731693226 0.9488139701226574 0.9213160418593722 0.9685741701500759 0.8862086446666926 0.8505280353343868 0.9276961062135399 1.0 15.473401522292239 -4.76118893202983 24.134936205678255 0.9180098774822569 1.0481906606657025 0.4507780760183574 0.04121385698083843 3.4295654989590716 329464.47946903243 0.010160071614547737 0.05736719204303244 1.733049901442462e-05 4.76118893202983 0.13018078318344561 KGPDEAEESQYDS(ph)GIESLR ddPTM_A459_Selumetinib_30min_R1 1 KGPDEAEESQYDSGIESLR 19 1 H3BNC2;Q7LC14;O00221 H3BNC2 NFKBIE NF-kappa-B inhibitor epsilon 1 KGPDEAEESQYDS(0.854)GIES(0.146)LR 114.75 0.0002464 4902800.0 987.26 1135.4 1069.3 1243.4 1025.5 931.53 988.12 891.23 532.36 867.49 True False 1010.2612371264465 1002.4668401668605 924.094933244461 1026.2635315087186 932.7437060667303 922.1596539615676 913.585312860024 867.5916852769665 903.3760379639822 978.8407915681627 1.0320996487160556 1.0241367634064855 0.9440707224348553 1.0484478582718053 0.9529064523071397 0.9420936089966292 0.9333339198056965 0.886346066439499 0.9229039551127806 1.0 9.934930414370253 -6.45756263641624 4.938744441053958 0.9310617939685915 1.0081391308544367 0.4815795846787453 0.03680270082077789 0.1846112869865463 8.845416123673523 0.011608130104831593 0.012973981755298288 3.48688290703257e-07 6.45756263641624 0.07707733688584528 KGPDEAEESQYDS(ph)GIESLR ddPTM_A459_Selumetinib_30min_R2 2 KGPDEAEESQYDSGIESLR 19 1 H3BNC2;Q7LC14;O00221 H3BNC2 NFKBIE NF-kappa-B inhibitor epsilon 1 KGPDEAEESQYDS(0.976)GIES(0.024)LR;KGPDEAEESQYDS(0.982)GIES(0.018)LR 176.27 4.5127e-13 8165300.0 33621.0 30700.0 33025.0 36094.0 32961.0 28648.0 28816.0 30448.0 25198.0 32885.0 True False 31752.479415526683 33054.59128394141 30900.207454901265 31177.934934377052 28820.14450492129 32594.001959348596 30156.001097820772 30536.59863906225 30238.304090945512 31935.52460450889 0.99426828927193 1.0350414371860521 0.9675810194938382 0.976277525435581 0.9024478182785903 1.0206189615794423 0.9442776178338754 0.9561953034192797 0.9468547789778987 1.0 14.962874529390922 -5.354528073442069 5.980318431470824 0.9618611762809115 1.0143541042022883 0.28593252139504144 0.03171751409924976 0.24586471416539277 12.715762794565626 0.007940337734069734 0.01686735029003075 4.420505411467654e-06 5.354528073442069 0.05249292792137683 KGPGQPS(ph)SPQRLDR ddPTM_A459_Selumetinib_30min_R1 2 KGPGQPSSPQRLDR 14 2 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 KGPGQPS(0.642)S(0.358)PQRLDR;KGPGQPS(0.5)S(0.5)PQRLDR 121.45 0.0021693000000000003 54444200.0 4522.5 4259.6 7356.1 7217.4 5352.4 4832.3 5051.7 4962.7 3081.9 4328.6 True False 4627.865450746874 3760.884051765682 6357.18202416495 5957.016577377374 4868.276365042972 4783.691449377349 4670.646201852997 4831.073074878543 5229.759206929886 4884.217974134513 0.9475141108064358 0.7700074140184364 1.3015762314112216 1.2196459308171974 0.9967360979432198 0.9794180920488142 0.9562730874394769 0.9891190566151202 1.0707464807314633 1.0 12.253911871389056 -6.460826439433141 24.998251548782836 0.9948990105749813 1.0627622614535384 0.04467489460305285 0.13717726585698747 877.9884362620245 353703.7193914992 0.046651970631769006 0.052898295995641595 3.46077655966954e-07 6.460826439433141 0.06786325087855705 KGPGQPSS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 5 KGPGQPSSPQR 11 1 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 KGPGQPS(0.003)S(0.997)PQR;KGPGQPS(0.005)S(0.995)PQR;KGPGQPS(0.016)S(0.984)PQR;KGPGQPS(0.087)S(0.913)PQR;KGPGQPS(0.091)S(0.909)PQR 155.88 0.0009698 104615000.0 20013.5 27036.7 17099.5 18145.199999999997 18924.300000000003 18097.7 21480.0 19264.4 10966.1 18143.1 True False 20479.77561050803 23871.230594979173 14777.48182083014 14976.481447588872 17212.60040635653 17915.653569396865 19859.746306352776 18753.44553240981 18608.670767745174 20471.94361375961 1.0003825722118127 1.1660461285627435 0.7218406859472735 0.7315612884710602 0.8407897526050039 0.8751320298359649 0.9700957896838206 0.9160559391051291 0.9089840768825637 1.0 14.321360458404168 -10.031648101559616 15.432215609572522 0.9999985014244352 0.9004172477231469 0.05239173581478984 0.12260568122502342 0.0 0.0 0.1290406408255194 0.0312969524777063 9.297194110813027e-11 10.031648101559616 -0.09958125370128834 KGPGQPSS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 KGPGQPSSPQR 11 1 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 KGPGQPS(0.251)S(0.749)PQR 68.033 0.037534 267960000.0 10696.0 8889.2 9708.6 9922.1 11057.0 8672.8 9033.5 9111.6 9449.5 7144.1 True False 10101.559139480494 9570.973056717003 9083.95924592444 8570.692863422808 9667.920809165835 9867.39947616024 9453.57564954066 9138.113247493424 11339.664041090151 6937.831270399025 1.4560110711512748 1.3795338461966564 1.3093370092008567 1.235356198411823 1.3935076297423115 1.4222599385287045 1.3626125054201474 1.3171426186857742 1.6344681211075283 1.0 12.76026903904847 -10.652186328961859 4.38030550924929 0.999949141527843 1.3808951928820503 0.5704799646638758 0.10124940207089378 71807982.01158765 4.868605688255365 42343.96486051667 0.024362935858726495 2.2274792703335475e-11 10.652186328961859 0.38094605135420734 KGPGQPSS(ph)PQRLDR ddPTM_A459_Selumetinib_30min_R1 2 KGPGQPSSPQRLDR 14 2 O95400 O95400 CD2BP2 CD2 antigen cytoplasmic tail-binding protein 2 1 KGPGQPS(0.24)S(0.76)PQRLDR;KGPGQPS(0.309)S(0.691)PQRLDR 140.77 0.00063271 312314000.0 12958.4 12376.3 20396.9 21081.5 18498.4 13877.3 13762.2 13771.3 8228.3 10236.0 True False 13260.305507342897 10927.277042414222 17627.113012151844 17400.011773766335 16825.22298615777 13737.706961580252 12724.106173989214 13406.040388513273 13962.824128745646 11549.890307083331 1.1480893025633845 0.9460935776777661 1.5261714651386313 1.506508833516387 1.4567430978837241 1.1894231543614897 1.1016646769524518 1.1607071610274602 1.2089140032942571 1.0 13.495591529530316 -6.983868402768272 22.453729589862867 1.1332608551035392 1.3187881148721543 0.23307404793666064 0.17045564666858637 129.77034639519454 180625.66322223697 0.06699512613381964 0.05905388827303007 1.0378428489072364e-07 6.983868402768272 0.18552725976861506 KGS(ph)DSSIPDEEK ddPTM_A459_Selumetinib_30min_R1 2 KGSDSSIPDEEK 12 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 KGS(0.998)DS(0.001)S(0.001)IPDEEK;KGS(0.995)DS(0.002)S(0.002)IPDEEK 133.04 0.006525700000000001 0.0 2364.4 2853.0 2435.6 2179.1 1964.99 2338.0 2997.5 2685.0 1333.67 2318.16 True False 2419.4859196784764 2518.9694336762836 2104.858897793144 1798.56109177308 1787.2570014471607 2314.481842734151 2771.396161698907 2613.7850778908414 2263.1405825971583 2615.718416790572 0.9249795024370902 0.9630124624679605 0.8046962869863334 0.6875973653081031 0.6832757646903312 0.8848360082940305 1.059516247585758 0.9992608765196894 0.8652080315946168 1.0 11.35299152711699 -7.004286888594574 24.965956919915197 0.9796834844599741 0.810705095403063 0.4169878578662751 0.09378697241059428 201.44713938280591 1173192.2372116651 0.03786569358927468 0.032607964618266 9.901776319135067e-08 7.004286888594574 -0.1689783890569111 KGS(ph)DSSIPDEEK ddPTM_A459_Selumetinib_30min_R2 1 KGSDSSIPDEEK 12 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 KGS(0.997)DS(0.003)S(0.001)IPDEEK 101.56 0.011372 0.0 111610.0 72402.0 91705.0 94249.0 83788.0 64823.0 83258.0 88581.0 67716.0 86562.0 True False 105407.16301022987 77955.00059087714 85804.80014085435 81412.12361140625 73261.80236577608 73751.77984539427 87129.66197259724 88838.75604462606 81261.09214312509 84062.73014491421 1.253910773877084 0.9273431930713163 1.020723452509061 0.9684687074885787 0.871513478559183 0.8773421909835062 1.036483847507641 1.056815022441914 0.9666720555356764 1.0 16.359178691887152 -4.756325145672121 24.999235385462548 0.9689822596766738 1.2539112148364846 0.6719287040624566 0.0596219818246969 104.89207115210104 512672.78409215633 0.016268058923207953 0.1327094719645795 1.752567905759494e-05 4.756325145672121 0.28492895515981076 KGS(ph)GDYMPMSPK ddPTM_A459_Selumetinib_30min_R2 2 KGSGDYMPMSPK 12 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 KGS(0.999)GDYMPMS(0.001)PK;KGS(0.993)GDY(0.004)MPMS(0.003)PK 105.39 0.0047959 5621100.0 177108.5 138898.47 141964.6 140897.7 125928.3 96517.5 107768.0 115261.14 88677.8 129782.4 True False 167265.51859149968 149551.53602002622 132830.75219536957 121707.19019791059 110108.0611407143 109811.90952636927 112779.4255382408 115596.530834891 106415.83786475287 126035.2448968291 1.3271328883315232 1.1865850393074355 1.0539175157242975 0.965659965175127 0.8736291283509419 0.8712793759893112 0.8948245042929115 0.9171762305815084 0.8443339635025391 1.0 16.94346770441289 -5.184078002702527 1.0706996781351044 0.8926973127602429 1.3971862040776697 0.9220104288067938 0.041438792680987234 0.23308709833527838 0.3408924232429406 0.01332491921606326 0.11478448761327215 6.545186068232553e-06 5.184078002702527 0.5044888913174268 KGS(ph)ITEYTAAEEK ddPTM_A459_Selumetinib_30min_R1 4 KGSITEYTAAEEK 13 1 J3KN59;Q12982;Q12982-2 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 KGS(0.998)IT(0.002)EYTAAEEK;KGS(0.773)IT(0.226)EYT(0.001)AAEEK;KGS(0.992)IT(0.008)EYTAAEEK;KGS(0.991)IT(0.006)EYT(0.002)AAEEK 218.34 2.9583e-08 170276000.0 14521.7 20788.4 15261.800000000001 16908.300000000003 12881.1 15381.3 17121.4 17420.6 11722.9 15356.6 True False 14860.027355690632 18354.484463735036 13189.331387066613 13955.582813100264 11716.006779342919 15226.578087103002 15829.919013481773 16958.549097916275 19892.905093260124 17327.769195951132 0.8575845619621295 1.0592525936935846 0.7611673053764174 0.8053883137109867 0.6761405145031896 0.8787385101286378 0.913557817770371 0.978692000461252 1.1480361302312574 1.0 14.080798311191295 -7.754196330166474 1.9267625306424212 1.070860053470667 0.8388657730377003 0.46837379391744804 0.09869711226093907 0.32736360382281005 2.3670097859479373 0.07556169818095049 0.03099442564979819 1.7611796953522244e-08 7.754196330166474 -0.23199428043296666 KGS(ph)ITEYTAAEEK ddPTM_A459_Selumetinib_30min_R2 4 KGSITEYTAAEEK 13 1 J3KN59;Q12982;Q12982-2 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 KGS(0.738)IT(0.262)EYTAAEEK;KGS(0.966)IT(0.034)EYTAAEEK;KGS(0.987)IT(0.013)EYTAAEEK;KGS(0.767)IT(0.23)EYT(0.003)AAEEK 170.47 0.00040765 265675000.0 449355.0 348152.0 380527.0 382041.0 331892.0 305846.0 397408.0 383791.0 284168.0 363778.0 True False 424381.64801058866 374854.1389148787 356044.3071064716 330006.35674251604 290196.7598078739 347973.5103064414 415888.25944901304 384907.7682699797 341009.54031731864 353274.78393124655 1.20127919487506 1.0610837681181113 1.0078395722004434 0.9341350465781929 0.8214477030558492 0.9849939088043236 1.177237318840034 1.0895421518250492 0.965281293282696 1.0 18.430431250567032 -4.789180224534056 2.221109472635864 0.9984444791722557 1.2516311010651617 0.3323292370236327 0.08781168087239327 0.8608758814485511 5.043126103818636 0.02662285304424749 0.4347300354365291 1.624874321696378e-05 4.789180224534056 0.2531866218929061 KGS(ph)PCDTLASSTEK ddPTM_A459_Selumetinib_30min_R2 1 KGSPCDTLASSTEK 14 1 Q15788-2;Q15788-3;Q15788 Q15788-2 NCOA1 Nuclear receptor coactivator 1 1 KGS(0.938)PCDT(0.06)LASSTEK 66.939 0.034759 8861200.0 24358.0 20965.0 28745.0 25682.0 22915.0 21306.0 19395.0 25894.0 17039.0 23266.0 True False 23004.27987279972 22572.94808690007 26895.577995189615 22184.06729607889 20036.212837300813 24240.70810338877 20296.905930463407 25969.347253017528 20447.27610943806 22594.250127672316 1.0181475261542414 0.999057191955835 1.1903726763761566 0.9818456983845172 0.8867837048843438 1.0728706625098372 0.8983217329972267 1.149378585537192 0.9049769739600807 1.0 14.46366805627332 KGS(ph)PTPGFSTR ddPTM_A459_Selumetinib_30min_R1 1 KGSPTPGFSTR 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 KGS(0.964)PT(0.036)PGFS(0.001)TR 124.48 0.006391399999999999 206140000.0 4700.6 4779.4 5347.3 6041.0 4246.7 4341.4 4761.2 4502.3 2709.5 3849.2 True False 4810.1148342246015 4219.82562611722 4621.166030616395 4986.052753614419 3862.5867348157813 4297.72945767581 4402.058850735888 4382.884378468509 4597.82360594975 4343.282314383071 1.1074838074180864 0.971575255917163 1.063980118288211 1.147991862537411 0.889324353156728 0.9895118821642311 1.0135327459967718 1.0091180036707015 1.0586057440299814 1.0 12.084570016022406 -4.7415944541293005 24.171539733247478 1.017011845083226 1.1074842826113673 0.15649693565372869 0.06370281601396473 1867.6711610392615 2274681.218168542 0.016194819087296426 0.5876319574444968 1.813032319000376e-05 4.7415944541293005 0.09047243752814138 KGS(ph)PTPGFSTR ddPTM_A459_Selumetinib_30min_R2 1 KGSPTPGFSTR 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 KGS(0.933)PT(0.067)PGFSTR 130.19 0.0043855 20444000.0 58582.0 50788.0 52383.0 47934.0 58271.0 37489.0 36233.0 48594.0 31682.0 44133.0 True False 55326.24696232665 54683.27629084091 49012.73481029807 41405.30650923782 50950.47603065046 42652.76945874123 37917.906294327455 48735.40049483026 38019.285269042586 42858.76561869518 1.2908968833715804 1.275894802415584 1.143587177623205 0.9660872382002678 1.1887994274950757 0.9951936049258476 0.8847176475327021 1.1371162886121868 0.887083067377433 1.0 15.387302678900545 -4.995526237986081 0.6299567205795377 0.9882676002789172 1.4808675475692177 0.5884245861926259 0.09159041162656252 1.957397725255757 0.7065346623257989 0.045192319614678525 0.6706647291422435 1.0103544579220592e-05 4.995526237986081 0.49259994729030043 KGS(ph)QITQQSTNQSR ddPTM_A459_Selumetinib_30min_R1 1 KGSQITQQSTNQSR 14 1 P50750-2;P50750 P50750-2 CDK9 Cyclin-dependent kinase 9 1 KGS(0.999)QITQQSTNQSR 63.374 0.040307 2202600.0 788.78 1269.7 1053.6 1301.8 1092.0 1024.0 1124.9 1131.8 709.89 1154.2 True False 807.157039301297 1121.0429337324842 910.5269070105347 1074.4650678124897 993.2287928082587 1013.6994897176098 1040.0478873378147 1101.7809873954773 1204.6314816857976 1302.3528128600603 0.6197683387566247 0.860782825255004 0.6991399703824897 0.8250184260383998 0.7626418763031324 0.7783601184777671 0.7985915007576133 0.8459927114342288 0.9249655468093475 1.0 10.346904618274728 -8.230581474703174 0.8288861986879041 1.0036050093192355 0.7563564675426366 0.6439502302864568 0.06121497504936332 0.35052283284825564 0.5129497413725073 0.05347320179556383 0.02042212866473975 5.880557830961845e-09 8.230581474703174 -0.24724854177659883 KGS(ph)QITQQSTNQSR ddPTM_A459_Selumetinib_30min_R2 3 KGSQITQQSTNQSR 14 1 P50750-2;P50750 P50750-2 CDK9 Cyclin-dependent kinase 9 1 KGS(1)QITQQSTNQSR;KGS(0.998)QIT(0.001)QQSTNQSR;KGS(1)QITQQSTNQSR 87.38799999999998 0.011358 21298300.0 46404.0 37708.0 39887.3 41119.0 41210.0 29983.6 40237.0 47886.0 31210.7 33607.6 True False 43825.05144993014 40600.082349669785 37320.994544008594 35518.52126576855 36032.83137792564 34113.56873597893 42108.10022810291 48025.34033204597 37453.71209982033 32637.2612649686 1.342791942440649 1.243979450973361 1.1435087717996517 1.0882813045312894 1.1040396767789367 1.0452338037504063 1.2901848560834939 1.4714880621308215 1.147575214591351 1.0 14.9942323791008 -7.302481134222954 24.92722317459716 1.26660273590615 1.1583323866101238 0.021768965846641786 0.13784242047117296 1125.2517681449149 683431.0652510818 0.058193990044206695 0.0392349586275209 4.9833210307531e-08 7.302481134222954 -0.10827034929602619 KGS(ph)SGNASEVSVACLTER ddPTM_A459_Selumetinib_30min_R1 2 KGSSGNASEVSVACLTER 18 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1;C9J8U1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 KGS(0.453)S(0.453)GNAS(0.001)EVS(0.093)VACLTER;KGS(0.845)S(0.155)GNASEVSVACLTER 162.92 1.1449000000000003e-05 62180000.0 5611.7 5142.0 6722.700000000001 6468.9 5480.4 6284.4 6073.1 6378.6 3964.5 4625.7 True False 5742.441691532609 4539.972249549054 5809.794265147795 5339.228051292221 4984.698787643208 6221.184641778662 5615.001177519142 6209.41880738716 6727.466944376374 5219.453653133583 1.100199766710265 0.8698175233002421 1.1131039091916817 1.0229476888039286 0.9550230960764567 1.1919225756595564 1.0757833196101063 1.1896683484600414 1.2889216748456862 1.0 12.349683085103525 -6.766249600967342 24.9952032994217 1.156521226598949 1.0105080560435031 0.33536238207140456 0.09617539260568021 133.7134948643534 694806.680443291 0.03225203597448985 0.02934299626802645 1.7129725321830444e-07 6.766249600967342 -0.14601317055544594 KGS(ph)SGNASEVSVACLTER ddPTM_A459_Selumetinib_30min_R2 4 KGSSGNASEVSVACLTER 18 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1;C9J8U1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 KGS(0.933)S(0.067)GNASEVSVACLTER;KGS(0.939)S(0.061)GNASEVSVACLTER;KGS(0.818)S(0.182)GNASEVSVACLTER;KGS(0.969)S(0.031)GNASEVSVACLTER 134.09 0.00020713 139019000.0 113739.0 120054.0 124040.0 114755.0 111960.0 88574.0 92045.0 106894.0 93137.0 142644.0 True False 107417.84171329203 129261.75576554716 116059.4014445405 99125.17103658334 97894.58386490073 100774.26450528271 96325.27488370729 107205.04384274564 111767.00246521096 138525.49708637886 0.7754373308352803 0.9331260921947444 0.8378197796480065 0.7155734729092719 0.7066900023744918 0.7274780933826499 0.6953613371525588 0.7739011669158418 0.8068334336711862 1.0 17.07979201846996 -5.62400005129649 6.114790652415432 0.7578845496688206 0.8615914867155328 0.10095700778155792 0.0911683452761792 0.31795708847754317 16.327789223428113 0.023485516868582485 0.041109475896813366 2.3768400058855107e-06 5.62400005129649 0.10370693704671219 KGSGDYMPMS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 KGSGDYMPMSPK 12 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 KGSGDYMPMS(1)PK;KGSGDYMPMS(1)PK 120.7 0.0071227 25318200.0 10789.6 13474.9 15084.9 14958.6 11149.2 12111.3 12972.6 12082.3 8982.9 10919.400000000001 True False 11040.97668709308 11897.25244368894 13036.453435424455 12346.361317698498 10140.756828551133 11989.471318180553 11994.066337699827 11761.838155158488 15243.325214942235 12321.011353963035 0.8961096106401822 0.9656068079072264 1.058066830790745 1.002057458028988 0.8230458147649847 0.9730914917405833 0.9734644334892163 0.9546162905998224 1.2371813300893715 1.0 13.588833062161994 -8.229159399342414 24.298979964999095 1.1185906621499722 0.9577836072231029 0.4035496454392514 0.07915415628708003 390.73047701900316 294125.9225024381 0.05259221349779143 0.01987379990488359 5.8998449809352026e-09 8.229159399342414 -0.1608070549268693 KGSIT(ph)EYTAAEEK ddPTM_A459_Selumetinib_30min_R2 1 KGSITEYTAAEEK 13 1 J3KN59;Q12982;Q12982-2 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 KGS(0.013)IT(0.985)EYT(0.002)AAEEK 171.78 0.024621 33933000.0 49005.0 44494.0 42400.0 38356.0 35844.0 35502.0 43360.0 42557.0 34037.0 43677.0 True False 46281.498282558125 47906.5467292407 39672.0301616295 33131.84663220942 31340.95627057431 40392.07824493135 45376.32591621003 42680.8338243094 40845.351073240396 42415.931523525454 1.0911347840348309 1.1294470027770094 0.9353096522146617 0.7811179771882002 0.7388958616455575 0.9522855397512229 1.069794397679151 1.0062453491239964 0.9629719213071165 1.0 15.372318625775643 -5.2746866280386016 10.753842667159617 0.9245454156599715 1.1103283360517917 0.35862015667027003 0.0957069285572542 0.5159772530340662 416.6871721019186 0.02886320051122536 0.06293648399317177 5.312676504247505e-06 5.2746866280386016 0.1857829203918202 KGTDVNVFNTILTTR ddPTM_A459_Selumetinib_30min_R2 1 KGTDVNVFNTILTTR 15 1 P04083 P04083 ANXA1 Annexin A1 0 93.754 0.016434999999999998 1724500.0 12821.0 11709.0 13660.0 13441.0 13951.0 10997.0 9457.2 10615.0 10194.0 13545.0 False True 12108.46014652949 12607.042649630948 12781.130471883469 11610.312612981723 12198.350656477576 12511.736929173298 9896.978539086293 10645.887892592147 12233.084844158198 13153.92065586356 0.9205209962348344 0.9584247145364351 0.9716593862975816 0.8826503456067488 0.9273547389872674 0.9511792914453989 0.752397615738587 0.8093319224824868 0.9299953347905527 1.0 13.68320525265851 KGTENGVNGTLTSNVADS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 KGTENGVNGTLTSNVADSPR 20 1 G3XAN4;Q15629-2;Q15629 G3XAN4 TRAM1 Translocating chain-associated membrane protein 1 1 KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR 175.83 2.4374000000000003e-13 47342000.0 8618.6 10701.2 12317.2 9357.3 13521.8 10741.7 13257.0 13398.5 6870.400000000001 12773.1 True False 8819.396611123708 9448.298529147094 10644.591893536597 7723.2232132753215 12298.755577467684 10633.648250683249 12257.013816728075 13043.128255538346 11658.567005837669 14412.651805530097 0.6119204661379336 0.6555558724815517 0.7385588743254239 0.5358641364188054 0.8533305142880565 0.7377995662535292 0.8504343254879085 0.9049776842963577 0.8089120005913352 1.0 13.815048183119961 -7.029608548373106 0.3207706008907568 1.0011297988359633 0.5624103760272064 0.684987293287217 0.0755051460004011 1.0799526556734425 0.26235923264011995 0.09902347116039252 0.17108814225692523 9.34095869413541e-08 7.029608548373106 -0.43871942280875686 KGTENGVNGTLTSNVADS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 KGTENGVNGTLTSNVADSPR 20 1 G3XAN4;Q15629-2;Q15629 G3XAN4 TRAM1 Translocating chain-associated membrane protein 1 1 KGTENGVNGT(0.003)LT(0.104)S(0.256)NVADS(0.637)PR;KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR;KGTENGVNGTLTSNVADS(1)PR 201.85 4.3958e-16 173743200.0 505768.0 163946.5 399145.0 472012.0 234343.0 233347.7 699108.0 454658.0 438738.0 309979.4 True False 477659.43930972053 176520.66937891577 373464.4452562178 407723.1513338842 204902.73728699895 265489.22755548335 731617.9072562219 455980.9795073163 526497.8593639671 301029.48929879523 1.586752980322158 0.5863899573098145 1.2406241200028254 1.3544292696493505 0.6806733046795194 0.8819376074214597 2.4303861690109505 1.514738574514604 1.748990972912215 1.0 18.19954529690758 -7.221022201216085 24.999699961182678 1.7164245758202323 1.0388425590930592 0.32789636763869456 0.4316107204102474 538.2996615411043 332961.07468401076 0.15763700950455006 0.12210371418495469 6.011430061535757e-08 7.221022201216085 -0.6775820167271731 KGTTY(ph)EEEINNIK ddPTM_A459_Selumetinib_30min_R1 1 KGTTYEEEINNIK 13 1 A6PVS8-2;A6PVS8 A6PVS8-2 LRRIQ3 Leucine-rich repeat and IQ domain-containing protein 3 1 KGT(0.056)T(0.29)Y(0.654)EEEINNIK 58.78100000000001 0.03959 881620.0 1702.9 1117.5 1014.2 1062.9 1303.5 1243.3 1614.7 1866.1 250.12 1275.0 True False 1742.5742567334098 986.6625804883444 876.4772106018264 877.2844681040833 1185.5986551516166 1230.7935308260783 1492.9018789975717 1816.6049660529247 424.43537195798154 1438.658669551704 1.2112492654539162 0.685821175912279 0.6092322168919628 0.6097933350496899 0.8241000316781585 0.8555146240557547 1.0377040159656288 1.2627074124670528 0.2950215926410387 1.0 10.49050862923709 -6.766262315036242 3.029547600427974 0.9210905293509868 0.7582211063596538 0.02706513726840054 0.28050204173556426 0.7995649854342859 15.136809049863256 0.102367104195045 0.0949265146526064 1.7129223852598894e-07 6.766262315036242 -0.162869422991333 KGVAINMVTEEDKR ddPTM_A459_Selumetinib_30min_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 ; 93.649 0.0089863 40849000.0 4949.3 6239.799999999999 6958.9 7196.099999999999 5869.2 6240.6 5637.9 5152.0 3856.8 5090.3 False True 5064.609060338639 5509.24131519568 6013.919602501525 5939.436222526856 5338.331896291424 6177.825230011442 5212.628663900668 5015.352223945485 6544.70791047315 5743.689588720817 0.8817692847267159 0.9591815905257945 1.04704815774017 1.0340802946925332 0.9294255571844594 1.0755848021702217 0.9075401069962031 0.873193466756002 1.139460587028473 1.0 12.487762067090095 -4.848594984540179 3.6133119508375806 0.9946916509477306 0.8766417089991839 0.18024483663777502 0.07653695934151566 0.4464873778973866 9.764228235126293 0.019010665432938553 0.12625473199976203 1.4171147404017322e-05 4.848594984540179 -0.11804994194854668 KGVDLLLEGVQGES(ph)SPTRR ddPTM_A459_Selumetinib_30min_R1 2 KGVDLLLEGVQGESSPTRR 19 2 F5H7T0;F6RJM5;Q96S38-2;Q96S38 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 KGVDLLLEGVQGES(0.426)S(0.426)PT(0.149)RR;KGVDLLLEGVQGES(0.437)S(0.282)PT(0.282)RR 96.181 0.0018749000000000003 24053000.0 3871.2 4384.0 5753.4 6314.0 5532.5 4014.7999999999997 4342.2 4215.4 2805.3 2979.3 True False 3961.391427956063 3870.719241933695 4972.11988116402 5211.378428459106 5032.08635184221 3974.4147571467383 4014.664358074722 4103.593898451045 4760.389208994587 3361.722175839523 1.1783815618156444 1.1514096166995298 1.479039498533912 1.5502109204362398 1.4968775195069612 1.1822555670157981 1.1942284781674855 1.220682044442371 1.4160566995116943 1.0 11.714984784935012 -6.783202968416381 24.989880418660764 1.2159111403888028 1.374912109474947 0.23093677388369072 0.15275041189529504 429.1085416282076 492717.2978561428 0.0583497930233694 0.051503172589663235 1.6473922994193273e-07 6.783202968416381 0.15900096908614425 KGVEPSPS(ph)PIKPGDIK ddPTM_A459_Selumetinib_30min_R1 1 KGVEPSPSPIKPGDIK 16 2 Q92890;Q92890-1;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 KGVEPS(0.142)PS(0.858)PIKPGDIK 125.04 0.0013994 17476000.0 3729.9 4496.6 3377.7 3877.2 3110.7 3190.9 3420.2 3793.7 1911.7 3825.1 True False 3816.7994128779997 3970.135981587372 2919.026892378019 3200.1198040579093 2829.3377342386916 3158.802443105392 3162.2115603811835 3693.0787523256945 3244.015274956314 4316.088844629196 0.8843190097042382 0.9198457502856281 0.6763129762748892 0.74143974307666 0.6555327835198365 0.7318668722577631 0.7326567348853672 0.8556540157696811 0.7516099393998953 1.0 12.075508846982624 -11.23310128729262 8.377939337052213 1.0008610781018856 0.7694418338703441 0.40426108970302466 0.0829252763480502 0.001442027316172402 4.9877001207845093e-05 0.08681151612217218 0.02098232929830721 5.846537137776433e-12 11.23310128729262 -0.23141924423154148 KGVEPSPS(ph)PIKPGDIK ddPTM_A459_Selumetinib_30min_R2 1 KGVEPSPSPIKPGDIK 16 2 Q92890;Q92890-1;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 KGVEPS(0.05)PS(0.95)PIKPGDIK 48.351000000000006 0.048143 37238000.0 279670.0 300470.0 304890.0 297950.0 267590.0 249260.0 283650.0 304280.0 226020.0 302640.0 True False 264127.06100771396 323515.0828366735 285273.70933913306 257368.69600758195 233972.9519150476 283593.3024430057 296840.2870418122 305165.404423734 271230.3155264507 293901.9968468467 0.8986909372560385 1.1007583694821177 0.9706422970912651 0.8756956358540756 0.7960917395092476 0.9649247214566804 1.0099975169494906 1.0383236850981883 0.9228597234328751 1.0 18.16497563550587 -6.998130511405374 24.99759190199273 0.9947706346880619 0.931687495877223 0.1329705577223853 0.07748532687966277 146.09179870366603 1953407.047753595 0.03017751062524693 0.026429063597644024 1.0043139349121818e-07 6.998130511405374 -0.06308313881083893 KGVNLPGAAVDLPAVSEK ddPTM_A459_Selumetinib_30min_R2 2 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 131.25 0.00073338 8686600.0 166222.0 133141.0 163489.0 166927.0 159972.0 135559.0 134959.0 145588.0 108773.0 141480.0 False True 156984.04667938716 143352.48658420998 152970.2957333643 144191.2546348632 139874.88719217473 154231.02176791857 141234.8609161853 146011.6369766093 130530.63937155409 137395.1047908139 1.1425737977957637 1.043359490881908 1.113360595825185 1.049464279345298 1.0180485498747305 1.122536512510672 1.027946819002158 1.0627135311619305 0.950038500791487 1.0 17.067971078157413 -8.204722582600123 6.375536154317568 0.9753243647816326 1.0708414399352015 0.4752505869531558 0.04095324805167661 0.171387305756368 15.175823824959792 0.027497502256576507 0.010005750780824241 6.241333903354617e-09 8.204722582600123 0.09551707515356889 KGVNLPGAAVDLPAVSEKDIQDLK ddPTM_A459_Selumetinib_30min_R1 1 KGVNLPGAAVDLPAVSEKDIQDLK 24 2 P14618;P14618-3;B4DNK4;H3BQ34;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 109.37 2.6876e-07 19992000.0 4501.0 3479.5 8821.3 9290.4 6392.0 5428.8 3977.4 4701.7 2812.4 2989.4 False True 4605.864542578588 3072.118522424337 7623.415911932451 7668.0060424067915 5813.844728599258 5374.191200956015 3677.3815157768886 4576.995642726027 4772.437390431105 3373.1186092218522 1.3654617806757525 0.9107650451500271 2.2600497625819047 2.2732690221574305 1.7235814692980687 1.5932410992792785 1.0902022554804935 1.3569032616323853 1.4148442267590653 1.0 11.71986733350364 -7.0950709548218365 4.463106742906594 1.247472390180853 1.7200894878021273 0.26357907687736726 0.3880934302489039 0.3800238016069199 12.89946870721342 0.16880328725262725 0.1306743384244094 8.033948532010787e-08 7.0950709548218365 0.47261709762127424 KGVS(ph)ASAVPFTPSSPLLSCSQEGSR ddPTM_A459_Selumetinib_30min_R2 1 KGVSASAVPFTPSSPLLSCSQEGSR 25 1 J3QRU8;Q9Y2X7;Q9Y2X7-3;J3QL89 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 KGVS(0.708)AS(0.292)AVPFTPSSPLLSCSQEGSR 76.959 0.00013963 25826000.0 59847.0 71100.0 58319.0 58719.0 67887.0 65596.0 65060.0 56314.0 63839.0 77607.0 True False 56520.94332652289 76553.1413774668 54566.819032926214 50721.3709040751 59358.42814251969 74631.25357879887 68085.41891394423 56477.86441671542 76608.58381069406 75366.28426279839 0.7499499793493499 1.0157478523225305 0.7240216174470603 0.672998163571555 0.7875992391443881 0.9902472214042488 0.9033936007317788 0.7493783854300151 1.016483492055464 1.0 16.201631645678198 -6.737715411500895 24.33888329718847 0.9144550019019597 0.7924287149443757 0.2863429476748942 0.11022126385963567 277.03087114890917 284210.2847026742 0.03758926135761642 0.037566075610134045 1.829298543118622e-07 6.737715411500895 -0.122026286957584 KGVSASAVPFTPSS(ph)PLLSCSQEGSR ddPTM_A459_Selumetinib_30min_R1 1 KGVSASAVPFTPSSPLLSCSQEGSR 25 1 J3QRU8;Q9Y2X7;Q9Y2X7-3;J3QL89 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 KGVSASAVPFTPS(0.012)S(0.987)PLLS(0.001)CSQEGSR 180.36 7.0929e-21 35816000.0 3421.8 4063.0 4135.7 4514.3 4669.2 3397.2 3836.5 3890.9 1779.3 3165.0 True False 3501.5212823362413 3587.3020711625463 3574.0946557739817 3725.962248906071 4246.871684414215 3363.0272524108063 3547.1097162161277 3787.7006925755973 3019.342145069713 3571.2585797107 0.9804726272774938 1.0044923914339314 1.0007941390968984 1.043319089262896 1.1891806738783517 0.94169245305201 0.9932379963658279 1.0606066763394184 0.845456042366527 1.0 11.802216881806572 KGVSASAVPFTPSS(ph)PLLSCSQEGSR ddPTM_A459_Selumetinib_30min_R2 2 KGVSASAVPFTPSSPLLSCSQEGSR 25 1 J3QRU8;Q9Y2X7;Q9Y2X7-3;J3QL89 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 KGVSASAVPFTPS(0.1)S(0.881)PLLS(0.014)CS(0.005)QEGSR;KGVSASAVPFTPS(0.055)S(0.944)PLLS(0.001)CSQEGSR 201.47 1.7608e-31 46806000.0 203461.0 174645.0 214312.0 237449.0 219373.0 151496.0 157754.0 166158.0 126639.0 170943.0 True False 192153.4521389157 188039.70992781565 200523.3992452623 205108.03657762744 191813.4025204971 172363.19885623682 165089.8735836208 166641.49227106228 151970.33858930258 166007.43142674663 1.1574990980069852 1.1327186277849923 1.2079182089733518 1.2355352698058857 1.1554506980317791 1.0382860416239545 0.9944727905537728 1.0038194726517133 0.9154429851916712 1.0 17.340888300602614 -6.854583592009685 2.361073796419112 0.9791138840897192 1.1837996022629913 0.8839284284770955 0.03461019894074195 0.10070330266650515 1.1463257251156196 0.014803447480682413 0.01289767907627428 1.3977078618141787e-07 6.854583592009685 0.20468571817327208 KGWMSILDEPGEPPS(ph)PSLTTTSTSQWK ddPTM_A459_Selumetinib_30min_R1 1 KGWMSILDEPGEPPSPSLTTTSTSQWK 27 1 F6TR96;Q9H2D6-6;Q9H2D6-5;Q9H2D6-7;Q9H2D6-3;Q9H2D6 F6TR96 TRIOBP TRIO and F-actin-binding protein 1 KGWMSILDEPGEPPS(0.89)PS(0.027)LT(0.061)T(0.016)T(0.004)STSQWK 127.41 3.5266e-12 7600000.0 522.85 677.83 723.85 785.67 970.85 736.12 670.78 693.66 555.67 401.36 True False 535.0313877110007 598.4693484853824 625.5551458234389 648.467483352465 883.036788917489 728.715301143483 620.1825245519237 675.2618834747715 942.9314054689419 452.87846557746786 1.1814016968741916 1.3214789264096953 1.381287019301724 1.431879704250456 1.9498317010757487 1.6090747441795317 1.3694237454216895 1.4910443635551125 2.0820848795859717 1.0 8.82298013048044 -5.804066647963222 2.6287207867734517 1.6021215813368492 1.278711772308763 0.16811976312395782 0.283914134578436 0.45748216967821653 6.439560235717996 0.08206244318378737 0.1430701267025116 1.5701218308549828e-06 5.804066647963222 -0.32340980902808614 KHEAFESDLAAHQDR ddPTM_A459_Selumetinib_30min_R2 3 KHEAFESDLAAHQDR 15 1 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75;A0A494C1A0;P35609;P35609-2;H7C5W8;F6THM6;A0A494C060 O43707;P12814-4 ACTN4;ACTN1;ACTN2 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2 0 ;; 132.65 0.0004089 30668200.0 194519.0 149284.0 199336.0 206783.0 246972.0 186724.0 180271.0 208049.0 176986.0 189453.0 False True 183708.41270125317 160733.6027762836 186510.93878062643 178618.79867942812 215945.16940230635 212443.53608829266 188653.95870020977 208654.38814563397 212388.14540201938 183982.99963199112 0.9985075418311083 0.8736329068326327 1.013740069211241 0.9708440401379875 1.1737234952916684 1.1546911209906854 1.02538799279043 1.1340960228009729 1.1543900568359315 1.0 17.489212939198858 -6.2019382503245515 7.996980663076834 1.1119604274812962 0.9606718629772255 0.550311777360881 0.0631493390364107 0.2395212232608784 29.613554369120276 0.018389709987419307 0.023745512505171647 6.281476649378081e-07 6.2019382503245515 -0.1512885645040707 KHES(ph)PLLVTK ddPTM_A459_Selumetinib_30min_R2 1 KHESPLLVTK 10 1 E9PEM3;H0Y6E6;Q92622-3;Q92622-2;Q92622 E9PEM3 KIAA0226 Run domain Beclin-1 interacting and cysteine-rich containing protein 1 KHES(1)PLLVTK 77.204 0.028535 4095100.0 46089.0 41773.0 41623.0 50085.0 45345.0 29870.0 33708.0 39487.0 28096.0 33409.0 True False 43527.557888885196 44976.85477863467 38945.021495695866 43263.33659855586 39648.35571055661 33984.32136713706 35275.48879113488 39601.90063257524 33715.98506783097 32444.395362993397 1.3416048412026638 1.3862750183945791 1.2003620674687372 1.3334610219891083 1.2220402096252398 1.0474635445325675 1.0872598609549269 1.2206083728638633 1.0391928926586798 1.0 14.985681659611517 -5.318737731834653 0.2648302759668072 1.0024822564659057 1.6015238555557956 0.7083155421373994 0.07120589028706042 4.04016240369929 0.30199482711464326 0.10469969252454046 0.77692968778153 4.8002324465064626e-06 5.318737731834653 0.5990415990898899 KHLEINPDHPIVETLR ddPTM_A459_Selumetinib_30min_R1 2 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 92.952 0.0034271 32395000.0 11736.3 13366.800000000001 21327.9 21151.3 17331.4 14685.8 11934.8 12606.9 8250.3 9417.0 False True 12009.732955135549 11801.808841943268 18431.688325768766 17457.622514074606 15763.777930107206 14538.074185639533 11034.5484272374 12272.524059017527 14000.156521929212 10625.763679347763 1.130246570275007 1.110678648432702 1.7346224593336854 1.6429522659162132 1.4835430568388877 1.3681909954289437 1.038471093488005 1.1549780730462138 1.3175670892380111 1.0 13.37527891179414 -7.119395676110171 5.086660955463234 1.1422429692622647 1.4323665414233624 0.3286048790613334 0.19889546230125077 0.3128233898637353 11.744422993898555 0.08529158049593163 0.06582546186638426 7.596338759261681e-08 7.119395676110171 0.29012357216109774 KHLEINPDHSIIETLR ddPTM_A459_Selumetinib_30min_R1 1 KHLEINPDHSIIETLR 16 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 123.72 0.0004435 12215000.0 5137.6 5508.1 9472.4 7759.9 7586.7 4870.6 4879.9 5099.4 3217.2 3673.7 False True 5257.296083970618 4863.209091353784 8186.100108168746 6404.779136363604 6900.484324540673 4821.606186150969 4511.805214169973 4964.147346814362 5459.35342500887 4145.255179868308 1.2682683829702468 1.1731989661269262 1.974812105157013 1.5450868181695583 1.664670575180343 1.1631626949210272 1.0884264100511443 1.197549277767761 1.3170126296500544 1.0 12.017245200713353 -6.7747991253035265 24.765074962307917 1.1615266669769937 1.5317337861931326 0.42406658727104274 0.21657351659841065 223.10748747237452 413573.5410300199 0.08031220841922525 0.07123831621907616 1.679580696766117e-07 6.7747991253035265 0.3702071192161389 KHS(ph)EEAEFTPPLK ddPTM_A459_Selumetinib_30min_R2 2 KHSEEAEFTPPLK 13 1 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 KHS(1)EEAEFTPPLK;KHS(1)EEAEFTPPLK 82.007 0.017409 10099000.0 112141.0 88988.0 97491.0 101562.0 87660.0 70276.0 83378.0 96905.0 71618.0 96862.0 True False 105908.65215599125 95813.0934584814 91218.53520017509 87729.08039577799 76647.36710965686 79955.88109798866 87255.24221037257 97186.9775065137 85943.6011741143 94065.34238230032 1.1259051365119934 1.0185801808819008 0.9697358547789552 0.932639781814959 0.8148311074885228 0.8500036152851281 0.9276024516633327 1.0331858157867158 0.9136585164897647 1.0 16.521375651034923 -4.9203443402372615 1.4055342511749478 0.9199342391418684 1.1744003936766416 0.5185632668940958 0.0601325081769803 0.8271175567479967 1.8010169146710155 0.019468415447995012 0.27855240443107704 1.2013115697725241e-05 4.9203443402372615 0.25446615453477317 KHS(ph)PSPPPPTPTESR ddPTM_A459_Selumetinib_30min_R1 2 KHSPSPPPPTPTESR 15 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 KHS(0.995)PS(0.005)PPPPTPTESR;KHS(0.872)PS(0.128)PPPPTPTESR 95.554 0.0055159 18697500.0 1305.31 1182.55 1669.9299999999998 1849.66 1548.0800000000002 1406.99 1341.3600000000001 1339.41 918.8699999999999 1248.69 True False 1335.7211833088772 1044.0964962474204 1443.1626782688888 1526.6516034183828 1408.0564373357222 1392.8369580447065 1240.1801352648683 1303.8844957831557 1559.255278390495 1408.9715247706015 0.9480114820108587 0.7410344906845527 1.0242667455638284 1.0835219708694548 0.9993505280846409 0.9885486921188689 0.8802024125127621 0.9254157893612823 1.1066620233111961 1.0 10.460426739824639 -5.2805923367314875 24.797154394068624 0.9964622874687294 0.8445229719915004 0.3917681432295209 0.07782265295257704 669.2364950422822 866453.4669609842 0.020814348308079676 0.043440141801505544 5.240921602604259e-06 5.2805923367314875 -0.15193931547722905 KHS(ph)PSPPPPTPTESR ddPTM_A459_Selumetinib_30min_R2 2 KHSPSPPPPTPTESR 15 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 KHS(0.997)PS(0.003)PPPPTPTESR;KHS(0.95)PS(0.05)PPPPTPTESR 95.9 0.005401100000000001 7455100.0 6491.8 7107.1 9207.5 8867.3 9023.900000000001 5493.4 6736.4 7335.5 5526.4 8015.0 True False 6131.011744734426 7652.191717071667 8615.099474368006 7659.5584430543 7890.237007310439 6250.065985879835 7049.655947923367 7356.8450905426025 6631.834420517553 7783.586124529083 0.7876847055643469 0.9831190398159351 1.106829080649407 0.9840654835071557 1.0137020238582906 0.8029802569002823 0.9057079648296281 0.9451742388201173 0.8520281415809204 1.0 12.926219284611044 -6.726964745172906 24.999905347582917 0.8980344215182493 0.9833452737197333 0.14487479840251694 0.08847787908447848 331.1162276508639 240114.074400927 0.029646400891603426 0.029645054754066945 1.875146721123362e-07 6.726964745172906 0.08531085220148404 KHSDS(ph)EVASLAR ddPTM_A459_Selumetinib_30min_R1 1 KHSDSEVASLAR 12 1 X6R7X0;Q96MN5-2;Q96MN5 X6R7X0 TCEANC2 Transcription elongation factor A N-terminal and central domain-containing protein 2 1 KHS(0.398)DS(0.602)EVASLAR 70.622 0.032191000000000004 45363000.0 1738.7 2160.7 2611.5 2476.8 2419.1 2356.9 2138.4 1899.7 1028.1 1466.5 True False 1779.2083270787361 1907.724239517822 2256.8726439426823 2044.2733752941892 2200.292832126794 2333.191725893979 1977.098766364282 1849.3137849047425 1744.6106105469412 1654.7395599196655 1.0752195512658882 1.1528848924180182 1.3638838996828295 1.235404908911125 1.3296913214751536 1.4100054065349419 1.194809633039937 1.1175860115379868 1.0543112963538739 1.0 10.692388453247824 -7.868413120147514 2.152459895217283 1.031564322369092 1.2640191475139897 0.4970259340938308 0.09366616034730951 0.29720668892433316 2.649743522050603 0.07593792594808418 0.02886265931695367 1.3539009090940684e-08 7.868413120147514 0.23245482514489768 KHSEEAEFTPPLKCS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KHSEEAEFTPPLKCSPK 17 2 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 1 KHSEEAEFT(0.004)PPLKCS(0.996)PK 62.378 0.020644 9264200.0 37961.0 35067.0 35980.0 27651.0 31116.0 24506.0 30286.0 26002.0 20668.0 28263.0 True False 35851.27958992325 37756.52614182324 33665.08597206201 23884.886099364452 27206.929899430597 27881.479056680964 31694.359010570493 26077.66151513717 24802.177512170092 27446.97375390711 1.3062015474409006 1.375617089168111 1.2265500114477919 0.8702192931548386 0.9912542688083292 1.0158307180481783 1.1547487637342446 0.9501106296436409 0.9036397868322176 1.0 14.744359469001703 -5.591610977758906 5.075413120574327 0.9913248992912164 1.3330048475731096 0.8017954998733711 0.07396152811246336 0.08557829846820098 4.15509205244939 0.02154004764547644 0.03854522740117975 2.560878784431939e-06 5.591610977758906 0.3416799482818932 KHSSGEQDT(ph)STLPSPPLLTTVEDVNQDNK ddPTM_A459_Selumetinib_30min_R2 2 KHSSGEQDTSTLPSPPLLTTVEDVNQDNK 29 1 O15063 O15063 KIAA0355 Uncharacterized protein KIAA0355 1 KHS(0.152)S(0.152)GEQDT(0.22)S(0.22)T(0.22)LPS(0.036)PPLLTTVEDVNQDNK;KHS(0.181)S(0.181)GEQDT(0.211)S(0.211)T(0.211)LPS(0.003)PPLLT(0.001)TVEDVNQDNK 111.65 3.1374e-11 5495000.0 59951.0 50222.0 57090.0 65471.0 72491.0 47911.0 59775.0 62272.0 46047.0 60771.0 True False 56619.16342286787 54073.865910817745 53416.891554892136 56553.73685622546 63384.03250223756 54510.305357244826 62554.65594191548 62453.20121031547 55257.68666067815 59016.383327979594 0.9593804335350518 0.9162517738558438 0.9051197064725458 0.9582718165213863 1.0740074014699452 0.923646999076637 1.0599540740114854 1.0582349796536326 0.9363109622219182 1.0 15.848827891057024 -6.010530926025335 20.90495351020949 1.0104808746348273 0.9268248037662932 0.3700429079048684 0.048536159139452674 58.71646593268461 116562.87420119272 0.013587438262823251 0.018769436444521843 9.760432761041898e-07 6.010530926025335 -0.0836560708685341 KIAELEEEQSQGS(ph)TTNSDWMK ddPTM_A459_Selumetinib_30min_R1 2 KIAELEEEQSQGSTTNSDWMK 21 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KIAELEEEQS(0.002)QGS(0.378)T(0.369)T(0.102)NS(0.149)DWMK;KIAELEEEQS(0.162)QGS(0.556)T(0.117)T(0.117)NS(0.048)DWMK 78.554 0.0012195 26722000.0 2058.58 2041.66 3219.8100000000004 3880.6000000000004 2520.46 2619.3599999999997 2372.28 2039.52 1728.58 1583.8700000000001 True False 2106.540908700608 1802.6214980580157 2782.577487150333 3202.9260578838134 2292.4848380233543 2593.0116165885925 2193.337009666415 1985.4253043053752 2933.2740095119443 1787.1751427002812 1.1786986391931291 1.0086428884269263 1.5569696671956152 1.7921724521327238 1.2827421237291774 1.4508995535103268 1.2272647247949382 1.1109293414329575 1.6412907383436397 1.0 10.803465309709411 -7.272978534423333 23.87624530199618 1.2541153025366483 1.384131960099809 0.06280688945311119 0.2509990457619139 1478.8992003566168 3060048.1679892186 0.10977603090980477 0.07480406395938216 5.3336125691861883e-08 7.272978534423333 0.13001665756316072 KIAELEEEQSQGST(ph)TNSDWMK ddPTM_A459_Selumetinib_30min_R1 1 KIAELEEEQSQGSTTNSDWMK 21 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KIAELEEEQSQGS(0.1)T(0.387)T(0.257)NS(0.257)DWMK 117.55 0.00011341 10973000.0 3013.0 2592.8 3802.7 4476.5 3065.4 2923.8 2468.0 2191.5 1595.0 1980.2 True False 3083.197037722569 2289.2337706399812 3286.314226735916 3694.763309312191 2788.135111240328 2894.3892265979944 2281.8367730018003 2133.374301004759 2706.598505809133 2234.377958781399 1.3798905532545198 1.0245508203493467 1.4707960279594907 1.6535981724986526 1.2478350407470638 1.2953892671661322 1.021240280335689 0.9547956256103933 1.2113431817440936 1.0 11.125657531870205 -7.141475597421746 2.884233603919728 1.0413688156925396 1.3567621992160663 0.44941188621506334 0.16241346722694214 0.2784556346406338 4.457427844995406 0.07331014126466767 0.054195424788439535 7.219787290695982e-08 7.141475597421746 0.31539338352352675 KIAELEEEQSQGSTT(ph)NSDWMK ddPTM_A459_Selumetinib_30min_R2 1 KIAELEEEQSQGSTTNSDWMK 21 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KIAELEEEQSQGS(0.021)T(0.245)T(0.505)NS(0.229)DWMK 123.54 0.00010749 6351000.0 12926.0 16714.0 13868.0 14490.0 12036.0 10384.0 9480.1 7926.5 6245.9 15346.0 True False 12207.624666877786 17995.910056019427 12975.74797833674 12516.437003355784 10523.93007679479 11814.301743433254 9920.943434461778 7949.564802697283 7495.254525027244 14902.92110630358 0.8191430780448976 1.207542462826807 0.8706848735076714 0.8398646757957827 0.7061655900696823 0.7927507405535473 0.6657046201677506 0.5334232628618565 0.5029386166351596 1.0 13.863307519131796 -6.021622875772764 1.10617492422004 0.6587456512340158 1.0180432625545257 0.35639956581496957 0.1602211170429588 0.4972006458023111 1.2405978806202715 0.06252212235482521 0.12331584878629039 9.514306199335436e-07 6.021622875772764 0.35929761132050986 KIAELEEEQSQGSTTNS(ph)DWMK ddPTM_A459_Selumetinib_30min_R1 3 KIAELEEEQSQGSTTNSDWMK 21 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KIAELEEEQSQGS(0.188)T(0.188)T(0.131)NS(0.493)DWMK;KIAELEEEQS(0.021)QGS(0.039)T(0.14)T(0.028)NS(0.772)DWMK;KIAELEEEQSQGS(0.009)T(0.009)T(0.072)NS(0.91)DWMK 147.76 1.3885e-06 90821300.0 12511.2 13360.599999999999 20908.5 21686.399999999998 14773.3 15660.9 11687.6 11420.3 8605.4 9053.4 True False 12802.686617442627 11796.334740825574 18069.240542169468 17899.277344145634 13437.057623437957 15503.36556495949 10805.994922259262 11117.396545637535 14602.735286451369 10215.492077583845 1.25326186151482 1.154749536413485 1.7688076506680803 1.7521698620297053 1.3153607796263957 1.517632772578717 1.057804640265071 1.088287912241914 1.4294695914350108 1.0 13.318471079537515 -7.256649780360357 24.8060480145814 1.1512478588641861 1.4671379719468105 0.3455878139327837 0.21310612505708296 459.01523079885584 2377317.6837043553 0.08892791674309922 0.06657313846004591 5.5379651653547827e-08 7.256649780360357 0.3158901130826244 KIAELEEEQSQGSTTNS(ph)DWMK ddPTM_A459_Selumetinib_30min_R2 2 KIAELEEEQSQGSTTNSDWMK 21 1 P46821;D6RA32;D6RA40 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KIAELEEEQSQGS(0.385)T(0.131)T(0.069)NS(0.415)DWMK;KIAELEEEQS(0.01)QGS(0.035)T(0.206)T(0.144)NS(0.605)DWMK 150.22 9.6197e-07 18993500.0 44986.0 53114.0 50493.0 43595.0 46779.0 28919.0 25855.0 27608.0 20962.0 46123.0 True False 42485.85821322637 57187.67301157214 47244.335352621645 37657.28579443035 40902.20381043394 32902.32974945551 27057.30873071056 27688.33470924956 25154.985727216434 44791.30914805426 0.9485290566701814 1.2767582394732568 1.05476567332424 0.8407275096594533 0.9131727691913363 0.7345695041129378 0.6040749700187303 0.6181631043140061 0.561604163970036 1.0 15.45093121305282 -6.198938024544066 1.0573190399794585 0.6681176934955614 1.1255798372077939 0.5464930929832668 0.14611799244531576 0.35252353324132957 0.8202811359626662 0.06167608875642478 0.10092243247104993 6.325021053655278e-07 6.198938024544066 0.4574621437122325 KIALESEGRPEEQMESDNCS(ph)GGDDDWTHLSSK ddPTM_A459_Selumetinib_30min_R1 1 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 KIALES(0.001)EGRPEEQMES(0.034)DNCS(0.719)GGDDDWT(0.245)HLS(0.001)SK 62.848 0.00060794 6813900.0 2109.3 2004.0 2336.2 2440.3 3314.3 2369.8 2557.4 1713.0 544.31 932.13 True False 2158.442586016668 1769.370748365675 2018.956871828027 2014.1474151043326 3014.522150187192 2345.961963606242 2364.4932590254475 1667.5656753918122 923.6543151705143 1051.7779652150816 2.052184641057089 1.6822664163760555 1.9195656674697152 1.914992975435127 2.866120274321151 2.230472629388569 2.248091647881142 1.585473104155406 0.8781837476331168 1.0 10.038614462398693 -8.036647842705491 2.9903720874760706 0.9463824345056827 2.1276072783039015 0.7181290702544183 0.29793806160065367 0.15760701412433528 2.701971301513708 0.25460679925181007 0.08905757762949018 9.190775487880306e-09 8.036647842705491 1.1812248437982187 up KIALESEGRPEEQMESDNCSGGDDDWT(ph)HLSSK ddPTM_A459_Selumetinib_30min_R2 1 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 KIALES(0.001)EGRPEEQMES(0.004)DNCS(0.018)GGDDDWT(0.834)HLS(0.095)S(0.048)K 51.451 0.010079 4852800.0 7313.4 6632.5 6386.8 6734.2 6479.9 4073.3 5897.7 5401.9 4331.4 6452.6 True False 6906.950505859815 7141.191423151185 5975.880241422062 5816.990342857042 5665.837030958996 4634.360101264123 6171.954736070842 5417.61863466731 5197.801029427788 6266.296672131794 1.1022380310490583 1.1396191078712128 0.9536542162133328 0.9282979480890269 0.9041763145617998 0.7395692134837135 0.9849445468356899 0.864564657265778 0.8294853086902277 1.0 12.613397359076023 -5.433225506348874 1.9311769868854562 0.8823251289466174 1.1317639208859676 0.602986354960761 0.072187410643007 0.22857234836773882 1.614261863790729 0.020450355688600444 0.06208895913611072 3.6878605758629446e-06 5.433225506348874 0.24943879193935015 KICTLPS(ph)PPSPLASLAPVADSSTR ddPTM_A459_Selumetinib_30min_R1 1 KICTLPSPPSPLASLAPVADSSTR 24 1 Q9UER7-3;Q9UER7;Q9UER7-2 Q9UER7-3 DAXX Death domain-associated protein 6 1 KICT(0.018)LPS(0.978)PPS(0.004)PLASLAPVADSSTR 60.348 0.0042805 11237000.0 963.61 1180.3 1363.8 1652.3 1369.4 944.26 1061.0 1061.5 742.56 1096.9 True False 986.0602381413363 1042.1099272934164 1178.6034508171663 1363.756822512349 1245.5380117872069 934.7616017194821 980.967915784 1033.3455717620595 1260.070085563404 1237.6977997107954 0.7966890127555712 0.8419744525173425 0.952254622325872 1.1018495975600902 1.0063345124134853 0.7552421939652002 0.7925746624201936 0.8348932768592742 1.0180757256398423 1.0 10.273443389133691 -6.738003413690325 24.995143271356888 0.8643639853394648 0.9440769294726178 0.05884486210017825 0.10997157766170275 598.9990857012398 638848.4678036171 0.03923412358840521 0.03921261303025694 1.8280858467603214e-07 6.738003413690325 0.079712944133153 KICTLPSPPS(ph)PLASLAPVADSSTR ddPTM_A459_Selumetinib_30min_R1 1 KICTLPSPPSPLASLAPVADSSTR 24 1 Q9UER7-3;Q9UER7;Q9UER7-2 Q9UER7-3 DAXX Death domain-associated protein 6 1 KICTLPSPPS(0.965)PLAS(0.031)LAPVADS(0.001)S(0.001)T(0.001)R 57.078 0.0066347 63131000.0 3419.8 4584.1 4368.5 4396.7 4250.0 3925.6 4325.6 3815.4 2033.8 3758.7 True False 3499.4746862275624 4047.3914409097283 3775.2816944528463 3628.898881280669 3865.588250398442 3886.1120281596195 3999.316509439461 3714.2031978341597 3451.210057125151 4241.165757838426 0.8251209422220561 0.9543110720040668 0.8901518851215511 0.8556371263192958 0.9114447468255986 0.9162839299495419 0.9429757613335473 0.8757505388629657 0.8137409038415212 1.0 12.050245153670073 KICTLPSPPS(ph)PLASLAPVADSSTR ddPTM_A459_Selumetinib_30min_R2 2 KICTLPSPPSPLASLAPVADSSTR 24 1 Q9UER7-3;Q9UER7;Q9UER7-2 Q9UER7-3 DAXX Death domain-associated protein 6 1 KICT(0.002)LPS(0.001)PPS(0.992)PLAS(0.004)LAPVADSSTR;KICT(0.005)LPS(0.039)PPS(0.955)PLAS(0.001)LAPVADSSTR 98.446 4.039e-06 26111000.0 88042.0 94406.0 100173.0 118345.0 104264.0 73501.0 70555.0 71678.0 62191.0 101455.0 True False 83148.9781000506 101646.63663686549 93727.9782401158 102226.2068434881 91165.42418801347 83625.09557435349 73835.94730208021 71886.57111306829 74630.93776172672 98525.7305382528 0.843931606959949 1.0316760513376857 0.9513045752421571 1.0375584761972263 0.9252955922272337 0.8487640245599183 0.7494077628119008 0.7296223100336028 0.7574766241672384 1.0 16.588212921096087 -6.809879192201659 2.644783044730018 0.787819916096428 0.9702028300752317 0.3923604479042553 0.0874165531326178 0.23352591807749823 3.338159484650949 0.0317588676990178 0.02859958353736903 1.5492475135244812e-07 6.809879192201659 0.18238291397880368 KIDAGTMAEPSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 KIDAGTMAEPSASPSK 16 1 Q8IXQ3 Q8IXQ3 C9orf40 Uncharacterized protein C9orf40 1 KIDAGTMAEPS(0.137)AS(0.841)PS(0.022)K;KIDAGTMAEPS(0.196)AS(0.792)PS(0.012)K 153.76 6.8531e-05 42034000.0 15688.6 17444.6 20249.4 20848.8 16583.9 16412.0 16695.0 14539.3 9837.900000000001 15461.599999999999 True False 16054.113855298488 15402.178122225481 17499.64270199232 17207.948460446336 15083.889173125352 16246.910180903726 15435.68270877839 14153.670533697707 16694.197768212965 17446.246968737738 0.920204436178518 0.8828361853311453 1.0030605856577788 0.986340987335648 0.8645922071465835 0.9312553129631188 0.8847566319815307 0.8112730811996378 0.9568933535176716 1.0 14.09062909724918 -6.264938088673373 24.963242770070263 0.8986798407097492 0.94737309587789 0.09029467580300687 0.05764916075961635 628.4929242815795 4484285.403983613 0.017651471328376373 0.020818157490866348 5.433277806601017e-07 6.264938088673373 0.048693255168140825 KIDAGTMAEPSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 4 KIDAGTMAEPSASPSK 16 1 Q8IXQ3 Q8IXQ3 C9orf40 Uncharacterized protein C9orf40 1 KIDAGTMAEPS(0.327)AS(0.612)PS(0.061)K;KIDAGTMAEPS(0.35)AS(0.647)PS(0.003)K;KIDAGTMAEPS(0.294)AS(0.496)PS(0.21)K;KIDAGTMAEPS(0.079)AS(0.914)PS(0.007)K 161.64 2.3231e-05 61015000.0 652400.0 651060.0 616850.0 670360.0 644220.0 520270.0 562140.0 541960.0 433290.0 648960.0 True False 616142.219764124 700994.2085121461 577162.5425754989 579055.8115644997 563287.324200127 591932.4699591692 588280.6238592783 543537.0138736925 519960.107134128 630222.8385994252 0.9776577141085633 1.1122957874233812 0.9158070879471066 0.9188112142228352 0.8937907192509047 0.9392431275176404 0.9334485960023964 0.8624521051658826 0.8250416761945039 1.0 19.265502511459836 -5.330950812975255 8.211211009640703 0.9073463281533255 1.0446629838293493 0.5006701163170608 0.05339641412537944 0.22603579404030094 24.671935422992235 0.013623037756920803 0.02851902178940717 4.667122358934485e-06 5.330950812975255 0.1373166556760238 KIDTHPSPS(ph)HSSTVK ddPTM_A459_Selumetinib_30min_R2 1 KIDTHPSPSHSSTVK 15 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;H7C477 A0A0C4DG98 THOC2 THO complex subunit 2 1 KIDTHPS(0.039)PS(0.959)HS(0.001)ST(0.001)VK 81.128 0.019157 24101000.0 99167.0 101160.0 242350.0 322530.0 366660.0 176870.0 140810.0 198100.0 242410.0 288730.0 True False 93655.69513695409 108918.64671933293 226757.46485072948 278600.8576047169 320596.89281801094 201232.23703399848 147357.9440097217 198676.43820277933 290898.77350131364 280393.614689368 0.33401507819894494 0.3884490980295598 0.8087112293977916 0.9936062841993132 1.1433815751231777 0.717677673426808 0.5255395853895286 0.70856263407739 1.0374657562141125 1.0 18.09709397014457 -5.263407966975361 4.216983591785662 0.8563847181444066 0.34727164417333706 0.5738774960013825 0.17480699795105428 0.15849379303867758 7.09205952281663 0.05117910942633806 0.1310748743096849 5.4524542851615605e-06 5.263407966975361 -0.5091130739710696 KIEEAMDGSET(ph)PQLFTVLPEK ddPTM_A459_Selumetinib_30min_R1 2 KIEEAMDGSETPQLFTVLPEK 21 1 E9PPJ0;Q13435 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 KIEEAMDGSET(0.86)PQLFT(0.14)VLPEK;KIEEAMDGS(0.008)ET(0.982)PQLFT(0.009)VLPEK 126.04 8.3563e-05 45903000.0 8514.3 11162.1 7562.2 7805.8 7147.4 8185.5 9424.1 8717.7 5517.0 8573.2 True False 8712.666624056184 9855.236142880494 6535.294776191216 6442.663563013316 6500.918931975962 8103.1613018393555 8713.232549613565 8486.478276919555 9361.94605426269 9673.653730039741 0.9006593441525212 1.0187708199929548 0.6755766702602831 0.6660010522194749 0.6720231169520324 0.8376526106859178 0.9007178458906622 0.8772774500462392 0.9677776686580065 1.0 13.239845181873678 -7.750740266821427 1.2495853534642527 0.9801070423911861 0.7896583720200243 0.3191422742416967 0.10657365040157075 0.6690172585997978 1.9063248617027544 0.10152730350199543 0.03979186533516316 1.7752508660037142e-08 7.750740266821427 -0.19044867037116175 KIEEAMDGSET(ph)PQLFTVLPEK ddPTM_A459_Selumetinib_30min_R2 1 KIEEAMDGSETPQLFTVLPEK 21 1 E9PPJ0;Q13435 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 KIEEAMDGS(0.006)ET(0.993)PQLFT(0.001)VLPEK 82.406 0.0019637 3009000.0 35778.0 26408.0 29897.0 38964.0 37732.0 44450.0 39832.0 42489.0 28934.0 28312.0 True False 33789.60199068185 28433.408684896574 27973.459569392384 33657.03598335093 32991.76883164016 50572.58402307472 41684.26692561065 42612.63595556739 34721.60848350731 27494.55899658982 1.2289559543352853 1.0341467447585975 1.017418012518839 1.2241344182871035 1.1999380981426968 1.8393669827309211 1.5160914903483556 1.549857044837587 1.2628538063772496 1.0 14.746858525994364 -6.545538344222124 24.98610123832118 1.4783202025259905 1.1243500777120485 0.31545475547625135 0.21274053760315817 236.28939448223468 260547.80709243155 0.06811663736972252 0.06812065076106119 2.847486382126717e-07 6.545538344222124 -0.35397012481394197 KIFS(ph)GVFVK ddPTM_A459_Selumetinib_30min_R1 1 KIFSGVFVK 9 1 R4GMU7;Q6DKI1-2;Q6DKI1 R4GMU7 RPL7L1 60S ribosomal protein L7-like 1 1 KIFS(1)GVFVK 104.75 0.025405 41495000.0 1759.1 2311.9 1720.0 1891.1 1546.2 1959.3 1690.9 1879.1 995.99 1954.6 True False 1800.0836073872463 2041.2216732268487 1486.4334472837118 1560.8548853435234 1406.3464830037815 1939.5912209020644 1563.3540516486005 1829.2601638229726 1690.1222857685511 2205.4919494162823 0.8161823523607358 0.9255176260185805 0.6739691104640484 0.7077128011084456 0.637656593294749 0.8794369988135333 0.7088459570493406 0.8294113992604302 0.7663243958863093 1.0 11.106884778912937 -11.226978863360932 7.3967999024093185 1.0014860392321077 0.7705212408464014 0.381089242627473 0.08728183791862451 0.002199144397439007 8.797392688689401e-05 0.08688869818573579 0.020951424579109302 5.929541823115101e-12 11.226978863360932 -0.23096479838570627 KIFS(ph)GVFVK ddPTM_A459_Selumetinib_30min_R2 1 KIFSGVFVK 9 1 R4GMU7;Q6DKI1-2;Q6DKI1 R4GMU7 RPL7L1 60S ribosomal protein L7-like 1 1 KIFS(1)GVFVK 66.692 0.043379 28229000.0 96892.0 77532.0 93148.0 70268.0 82222.0 84480.0 73040.0 70255.0 63932.0 72631.0 True False 91507.13052940756 83478.45509532718 87154.95909187416 60697.37718093892 71892.53728599373 96116.35316691459 76436.50472601435 70459.4304186587 76720.18640933109 70533.95431199885 1.2973486517519812 1.1835215522735307 1.2356454411495803 0.8605412495725256 1.0192614037770427 1.362696223463595 1.0836838154274782 0.9989434323643545 1.0877057320502428 1.0 16.10603030266425 -5.622970523914481 20.30458517531826 1.0691881475129577 1.2335961264915356 0.3105067671796702 0.12207869442826691 4.627374210284538 925.0112149544761 0.03508685393230872 0.060772227459656214 2.382481165715423e-06 5.622970523914481 0.16440797897857795 KIHSQEEALR ddPTM_A459_Selumetinib_30min_R1 1 KIHSQEEALR 10 1 F2Z2Y4;O00764-3;O00764-2;O00764 F2Z2Y4 PDXK Pyridoxal kinase 0 78.098 0.036014 5349400.0 1547.6 1831.4 2335.7 2668.3 2082.6 1833.9 1829.1 1808.7 1038.4 1853.7 False True 1583.6560688946074 1616.9788366052392 2018.5247690817246 2202.3314951943985 1894.2291977128934 1815.4526310479737 1691.129514383142 1760.7274005144013 1762.0889582647064 2091.6404515670533 0.7571358967111843 0.7730673000676581 0.9650438571167665 1.0529206841187335 0.9056189347905087 0.8679563591762819 0.8085182676191555 0.8417925744337501 0.8424435265365768 1.0 11.030419161427664 -13.684305860927912 0.010306263921953766 1.9150454035919162 1.6579260315759188e-07 0.10537180519594147 0.0881337912431219 40741.018634829285 36.40075244150078 3872.101451936854 2948.6445841430973 2.068683921931854e-14 13.684305860927912 -1.915045237799313 KIHSQEEALR ddPTM_A459_Selumetinib_30min_R2 2 KIHSQEEALR 10 1 F2Z2Y4;O00764-3;O00764-2;O00764 F2Z2Y4 PDXK Pyridoxal kinase 0 ; 96.665 0.014478 3896900.0 11133.599999999999 10567.0 13795.900000000001 12916.1 13495.5 10740.7 10751.3 11322.400000000001 7378.3 11255.900000000001 False True 10514.839083332077 11377.454921739709 12908.2868138402 11156.90489848473 11800.074638699234 12220.133930633045 11251.25675329679 11355.346309475774 8854.16616692687 10930.91292065963 0.9619360395286687 1.040851299824748 1.180897415205211 1.0206745748928228 1.0795141013699663 1.1179426658442007 1.0293062285796555 1.038828722897788 0.810011591089737 1.0 13.41612627562861 -8.10852122835879 6.390832324160191 0.9063025739838534 1.0644819838649415 0.4377619275947001 0.06998975464946898 0.20823557197209047 10.4870733221712 0.046895386700975025 0.017410032290264135 7.788947411683816e-09 8.10852122835879 0.15817940988108814 KIIPTLEEGLQLPS(ph)PTATSQLPLESDAVECLNYQHYK ddPTM_A459_Selumetinib_30min_R1 2 KIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYK 37 1 P61978;P61978-2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 KIIPTLEEGLQLPS(0.452)PT(0.452)AT(0.082)S(0.015)QLPLESDAVECLNYQHYK;KIIPTLEEGLQLPS(0.314)PT(0.314)AT(0.314)S(0.056)QLPLESDAVECLNYQHYK 131.84 6.0544e-30 469840000.0 9925.4 9874.3 16022.8 17631.8 13190.0 10699.6 10200.1 8797.6 6095.900000000001 6383.7 True False 10156.642508533558 8718.212365562475 13846.991766940388 14552.737119877289 11996.966828883642 10591.971738459508 9430.698244852383 8564.259069367774 10344.297073079568 7203.110077503694 1.41003572057772 1.210340015876011 1.922362926284641 2.0203407921430347 1.6655259602864911 1.4704720078538986 1.3092536617350545 1.1889668458788567 1.4360876012968669 1.0 12.814404236300627 -7.105751510007349 2.331019560392766 1.240246796772063 1.655464633694622 0.40057399529184545 0.23777466661869112 0.36755422195467 3.9210257227018794 0.11685111876114178 0.08596769349853052 7.838780254610919e-08 7.105751510007349 0.415217836922559 KIPEPS(ph)PVTRR ddPTM_A459_Selumetinib_30min_R2 1 KIPEPSPVTRR 11 2 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 KIPEPS(0.848)PVT(0.152)RR 54.276 0.046018 4878900.0 24285.0 34151.0 34748.0 38506.0 34363.0 16062.0 12969.0 14390.0 7493.5 30892.0 True False 22935.336920557565 36770.27188722745 32512.351510761822 33261.41637344498 30046.012730882274 18274.39470368114 13572.084197585978 14431.872517607255 8992.409385883804 30000.06769294476 0.7645095056219278 1.2256729639271735 1.0837426049677843 1.1087113773835653 1.0015314978088639 0.6091451156284825 0.4524017857725628 0.4810613317716365 0.29974630317246204 1.0 14.872678135609457 -6.782293575137584 3.425660945197975 0.5161841137864825 1.061733555517196 0.573273158128761 0.20113530317604703 0.15092580254330487 3.70508036221135 0.06920082652917454 0.063664157232944 1.6508454795737304e-07 6.782293575137584 0.5455494417307135 KIQSSLSS(ph)ASPSK ddPTM_A459_Selumetinib_30min_R2 1 KIQSSLSSASPSK 13 1 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 KIQS(0.003)S(0.003)LS(0.019)S(0.563)AS(0.406)PS(0.006)K 66.893 0.036727 18140000.0 92959.0 76746.0 86472.0 84869.0 102800.0 67489.0 70510.0 82447.0 65869.0 95356.0 True False 87792.71092436105 82632.17142271563 80908.48566359477 73309.69579280911 89885.3449563396 76784.99714585583 73788.85471291436 82686.90712016441 79044.64053363312 92602.82451535818 0.948056513220076 0.8923288447752594 0.8737150954847612 0.7916572326651947 0.9706544635842302 0.8291863401328653 0.7968315772125987 0.8929199249905254 0.8535877922441077 1.0 16.498768577917836 KIQSSLSSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 KIQSSLSSASPSK 13 1 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 KIQSS(0.001)LS(0.005)S(0.065)AS(0.929)PSK;KIQSSLS(0.001)S(0.042)AS(0.952)PS(0.005)K 166.64 0.00058669 26448000.0 7998.2 8987.6 9363.3 9685.4 8725.8 7086.700000000001 8486.2 7376.0 4904.9 6306.0 True False 8184.54249821197 7935.327613778114 8091.815288925341 7994.026707475103 7936.552930665113 7015.414232208779 7846.079101721188 7180.364519375368 8323.257060277878 7115.436525641608 1.1502516351200196 1.1152270960723067 1.1372197980777703 1.123476638245223 1.115399301513615 0.9859429153682445 1.10268415345237 1.0091249487645322 1.1697465124288153 1.0 12.796736552174204 -6.547925089706193 24.976804999585138 1.0564247973711516 1.1293655364881146 0.3513663789467183 0.05109105735555979 253.3755360465011 252670.2137318592 0.01566746660835779 0.015668078913114045 2.831880417155152e-07 6.547925089706193 0.07294073911696297 KIQSSLSSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 KIQSSLSSASPSK 13 1 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 KIQSSLS(0.008)S(0.21)AS(0.775)PS(0.008)K 78.08800000000002 0.021461 21265000.0 199330.0 196880.0 198150.0 193270.0 184060.0 146660.0 164570.0 171660.0 113100.0 180490.0 True False 188252.0365812121 211980.06293102234 185401.24472940734 166946.29259065373 160936.73728272252 166861.08375307414 172222.8310892687 172159.5021801572 135723.16027803556 175278.78473066213 1.0740149577741824 1.2093880229530136 1.0577506286017424 0.9524614906886061 0.9181757936650579 0.9519753574825223 0.982565182397349 0.9822038784939199 0.7743273693196313 1.0 17.419291861201152 -5.6227031341042855 3.053114037679706 0.9373523859163041 1.1419268131726559 0.6077359220533569 0.0670249370377076 0.15758853368749715 2.9229103751601517 0.0183745496754929 0.03566629272760348 2.383948481939373e-06 5.6227031341042855 0.20457442725635178 KIQVLQQQADDAEER ddPTM_A459_Selumetinib_30min_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;A0A087WWU8;P06753-5;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 0 148.85 0.00040128 11366000.0 3018.3 3194.2 3736.7 4203.7 4116.0 3546.1 3206.5 3063.9 2114.3 2651.6 False True 3088.6205174105653 2820.2215790567057 3229.2766642238666 3469.602708221972 3743.708526738823 3510.429453601187 2964.6311234320387 2982.6354190501884 3587.812677637777 2991.9586887712144 1.032307206981875 0.942600440855338 1.079318600334725 1.159642585054182 1.2512567572503313 1.1732880760606046 0.990866329324086 0.9968838908919377 1.1991518101846779 1.0 11.546874540129496 -5.431072719555654 5.225889364935031 1.1140266320275094 0.9892358385747816 0.23019287094178498 0.08813886122796324 0.3298011342994493 14.266390326725423 0.025085549188251583 0.0532592122087277 3.7061865909964496e-06 5.431072719555654 -0.12479079345272781 KIS(ph)GTTALQEALK ddPTM_A459_Selumetinib_30min_R2 1 KISGTTALQEALK 13 1 J3KP58;P30622-2;P30622-1;P30622;F5H0N7;Q9UDT6-2;Q9UDT6 J3KP58;Q9UDT6-2 CLIP1;CLIP2 CAP-Gly domain-containing linker protein 1;CAP-Gly domain-containing linker protein 2 1 KIS(0.786)GT(0.16)T(0.055)ALQEALK 88.637 0.01208 7276400.0 42350.0 41611.0 40520.0 48974.0 41393.0 32933.0 46077.0 44222.0 28398.0 38321.0 True False 39996.35654048232 44802.42989954677 37912.98731484027 42303.65671513775 36192.84128188488 37469.22181399146 48219.671799843374 44350.678698653785 34078.39350641599 37214.57316008472 1.0747498397585078 1.2038947674294587 1.018767221963052 1.1367497494371757 0.9725448448970598 1.0068427132782451 1.2957201360987907 1.1917556734527603 0.9157271093725049 1.0 15.183580068319422 -8.27033376148957 24.954677246150034 0.9578635406783921 1.1112531429024324 0.29103344604230696 0.09660223285772976 959.7180326009691 2692617.0982900243 0.09258226586046224 0.025272931702769463 5.36619238341176e-09 8.27033376148957 0.1533896022240403 KIVEPEVVGES(ph)DSEVEGDAWR ddPTM_A459_Selumetinib_30min_R1 2 KIVEPEVVGESDSEVEGDAWR 21 1 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 KIVEPEVVGES(0.953)DS(0.047)EVEGDAWR;KIVEPEVVGES(0.951)DS(0.049)EVEGDAWR 136.71 1.6594e-05 12748400.0 5238.200000000001 4948.6 7881.3 10046.599999999999 7822.1 5666.4 4962.7 5175.799999999999 2969.79 3919.5299999999997 True False 5360.239868237095 4369.215611458275 6811.062748882052 8292.149908038835 7114.592436103917 5609.401160679551 4588.359543507308 5038.520970632185 5039.516725120318 4422.639854955286 1.2120000823108596 0.9879202817210737 1.5400446277014146 1.874932207909267 1.608675512687851 1.2683377676331875 1.0374707627089157 1.1392564477043825 1.1394815970542709 1.0 12.110692049931737 -7.0062995907239625 5.092494300923062 1.0961698401092028 1.449062037040608 0.3709440413858973 0.2238305975534237 0.23981965231228983 18.594350721613665 0.09692225959198493 0.07988525660561217 9.855993519779923e-08 7.0062995907239625 0.35289219693140517 KKAEPSEVDMNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 KKAEPSEVDMNSPK 14 2 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KKAEPSEVDMNS(1)PK;KKAEPSEVDMNS(1)PK 105.92 0.006429000000000001 459920000.0 11318.4 18382.6 21780.9 23283.2 11632.0 14898.1 13232.2 11741.400000000001 9215.1 12406.099999999999 True False 11582.096698227397 16230.356646161104 18823.173413919656 19217.226199793946 10579.887653796397 14748.238640392507 12234.084500694664 11429.97993055774 15637.35165572523 13998.543780647362 0.8273786816482552 1.1594317880834983 1.344652251610787 1.372801807168063 0.755784874454072 1.0535552034192 0.8739540835388879 0.816512067945196 1.1170698824647374 1.0 13.77298913602624 -6.263052760516362 24.99972833435383 0.9297324880702895 1.1869198270589836 0.3207683460552897 0.17059011208179775 175.23372577036935 2715291.336869829 0.05328377597862882 0.06365973046521531 5.456915634089974e-07 6.263052760516362 0.25718733898869406 KKAEPSEVDMNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 KKAEPSEVDMNSPK 14 2 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KKAEPSEVDMNS(1)PK;KKAEPSEVDMNS(1)PK;KKAEPSEVDMNS(1)PK 113.14 0.0099307 735304000.0 845956.0 891799.0 764070.0 668240.0 659465.0 557377.0 654870.0 609814.0 399521.0 700146.0 True False 798941.1521501836 960197.1157142562 714910.568056515 577224.5592217027 576617.1110080989 634150.6223853622 685322.7526002871 611588.4577798573 479436.363549434 679930.9657822264 1.1750327494366166 1.4121979495515367 1.0514458144056527 0.8489458316663588 0.8480524347714182 0.9326691301017651 1.0079299033128426 0.8994861074995394 0.7051250607447574 1.0 19.375028749653495 -5.484646317123059 4.124285523741078 0.8940580996005917 1.289866110472213 0.7281126010049865 0.0974565224797746 0.10430771569920425 3.847010158875524 0.026229824808140317 0.05482067543580596 3.276073847838587e-06 5.484646317123059 0.3958080108716212 KKDELS(ph)DYAEK ddPTM_A459_Selumetinib_30min_R2 2 KKDELSDYAEK 11 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LP59 P46100-4 ATRX Transcriptional regulator ATRX 1 KKDELS(1)DYAEK;KKDELS(1)DYAEK 85.163 0.039858 138178000.0 274560.0 209042.0 229400.0 241240.0 216416.0 177439.0 254560.0 237920.0 150299.0 213740.0 True False 259301.054350763 225074.8492240287 214640.65375183473 208382.69583778788 189227.8872964125 201879.6116191308 266397.54440107074 238612.30781022395 180362.99970493763 207568.77083678704 1.2492296086035672 1.0843386908187977 1.034070071747972 1.0039212305286562 0.9116394847527611 0.9725914491148109 1.2834182296649106 1.1495578397862494 0.8689312895086635 1.0 17.663229877920777 -4.750411528249298 2.5284685989695306 1.0357675990536037 1.3059622192630946 0.26163091210641254 0.11128744375755062 0.9094405919647851 6.906128227766297 0.031015560693572773 0.5540181455310713 1.7765951482592476e-05 4.750411528249298 0.2701946202094909 KKEEPSQNDIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KKEEPSQNDISPK 13 2 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KKEEPSQNDIS(1)PK 184.87 0.0040645 67021000.0 5027.7 7708.5 9197.2 9348.1 4621.7 6444.4 5566.5 4860.3 3628.6 5498.5 True False 5144.835627798797 6805.985236415576 7948.270756603353 7715.629820569935 4203.668051027406 6379.5751870470385 5146.614423385141 4731.389055520618 6157.469177541709 6204.286034925528 0.8292389485006315 1.0969812155827323 1.2810935395080894 1.2435967292830574 0.6775425935174287 1.0282529127662334 0.8295256528170235 0.762600084665086 0.9924541104133054 1.0 12.59904948484267 -6.250322975663681 24.99667772366769 0.8745752309279712 1.1236290011464392 0.35309212123922984 0.1527076891471076 805.4023499904093 1811051.3077756222 0.04586779462507763 0.05864628063709135 5.619232792501313e-07 6.250322975663681 0.24905377021846797 KKEEPSQNDIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 KKEEPSQNDISPK 13 2 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 KKEEPSQNDIS(1)PK;KKEEPSQNDIS(1)PK;KKEEPSQNDIS(1)PK;KKEEPSQNDIS(1)PK 93.495 0.010864 2225380000.0 1929796.0 1833269.0 1525589.0 1259043.0 1266569.0 1056793.0 1481678.0 1327409.0 842288.0 1294488.0 True False 1822545.6639054671 1973874.837411079 1427434.2646757097 1087559.171429683 1107451.278949475 1202356.6431382943 1550578.9628892592 1331271.5404256114 1010769.1354930688 1257112.7679562545 1.4497869326937651 1.570165292824205 1.135486251560673 0.8651245927585139 0.8809482388361299 0.9564429491023468 1.2334446060953672 1.0589913445791503 0.8040401475965615 1.0 20.26168264030303 -5.397005348784624 3.796765638091712 0.9809492149489615 1.50867643195278 0.7674579957838913 0.11666464272446445 0.11254797278121967 2.8230247592553677 0.033752157486542915 0.07626045836315941 4.008617805704869e-06 5.397005348784624 0.5277272170038184 KKEPAITSQNS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 2 KKEPAITSQNSPEAR 15 2 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193;E5RIS7 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 KKEPAIT(0.002)S(0.003)QNS(0.995)PEAR;KKEPAITSQNS(1)PEAR 222.64 4.1364e-08 1280360000.0 10784.6 13155.3 14312.7 15281.7 12239.7 10177.9 11231.8 9741.599999999999 6370.7 8529.0 True False 11035.860196821386 11615.071360266948 12369.113954033479 12613.03796803666 11132.62129609455 10075.51956679381 10384.576283225942 9483.221122823623 10810.612602481659 9623.780229495278 1.146728201772347 1.2069136122486146 1.2852656294170364 1.3106115961979063 1.156782577180527 1.046939905788167 1.0790537642785059 0.9853946055167735 1.123322888167057 1.0 13.232387981889552 -6.595988295230828 3.499001294271667 1.04796042903095 1.2388251194256872 0.7279127950052848 0.05491207357417575 0.1279557328583839 3.1475291552058926 0.019401125467134076 0.019673467764650808 2.5351969562458586e-07 6.595988295230828 0.19086469039473708 KKEPAITSQNS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 7 KKEPAITSQNSPEAR 15 2 A0A1W2PRL9;A0A1W2PPZ5;P23193-2;P23193;E5RIS7 A0A1W2PRL9 TCEA1 Transcription elongation factor A protein 1 1 KKEPAITS(0.006)QNS(0.994)PEAR;KKEPAITSQNS(1)PEAR;KKEPAITS(0.012)QNS(0.987)PEAR;KKEPAITS(0.001)QNS(0.999)PEAR;KKEPAITSQNS(1)PEAR;KKEPAITS(0.004)QNS(0.996)PEAR;KKEPAITS(0.001)QNS(0.999)PEAR 189.45 0.00085606 2324880000.0 957438.0 1167738.0 1046078.0 1132483.0 1053680.0 758754.0 830433.0 865897.0 722832.0 970104.0 True False 904227.4288879873 1257299.7497305244 978774.480363608 978236.8617578599 921307.2983812834 863265.4762169636 869049.7799717718 868416.6169130347 867418.5976135521 942094.5768871077 0.9598053646330903 1.3345791182504472 1.0389344173890682 1.038363754295428 0.9779350406893221 0.9163257038050117 0.9224655372110384 0.9217934570672071 0.9207340949564726 1.0 19.845512373719558 -5.9462172251229255 1.5319340681995839 0.9331479085065095 1.1453011680174505 0.41736312524149166 0.09107048213026549 0.33070875260484667 1.575080313963654 0.029288687872424696 0.05357854916173723 1.131834101608713e-06 5.9462172251229255 0.212153259510941 KKGDDS(ph)DEEDLCISNK ddPTM_A459_Selumetinib_30min_R1 1 KKGDDSDEEDLCISNK 16 2 H3BRG5;Q9Y3M8-5;Q9Y3M8-3;Q9Y3M8-4;Q9Y3M8-2;Q9Y3M8 H3BRG5 STARD13 StAR-related lipid transfer protein 13 1 KKGDDS(0.926)DEEDLCIS(0.074)NK 77.668 0.030987 9430500.0 1656.9 1814.8 2423.8 2025.9 1648.9 1659.6 1452.2 1493.5 1261.7 1627.4 True False 1695.5025462338288 1602.3223723223691 2094.661272980384 1672.1145958529144 1499.7572861369392 1642.9059307962348 1342.6593848270732 1453.8875284282963 2141.012749077985 1836.2926422183866 0.9233291618407443 0.8725855212198842 1.1407012285633666 0.9105926568615271 0.8167310872220856 0.8946863332259909 0.7311794176798718 0.7917515405779142 1.1659431072443183 1.0 10.842580277963828 -2.4653430099733145 12.001692530221378 0.9139091096851572 1.1164493390070553 0.0 0.13501870719529335 0.0 0.0 0.03132042936791006 0.0 0.003424971721214902 2.4653430099733145 0.2025402293218982 KKLGAGEGGEASVS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 KKLGAGEGGEASVSPEK 17 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KKLGAGEGGEAS(0.034)VS(0.966)PEK;KKLGAGEGGEAS(0.004)VS(0.996)PEK 101.16 0.0046307 73167000.0 12586.7 12683.5 17046.9 17272.4 12302.7 11983.5 12131.7 12171.900000000001 7733.9 10734.2 True False 12879.945620545202 11198.509923600821 14732.024611919029 14256.09958310374 11189.922957218107 11862.956870147435 11216.596101712297 11849.061672096666 13123.86343829295 12112.039129962277 1.0634002650043715 0.9245767622974728 1.216312501457788 1.1770189503299715 0.9238678010490342 0.9794351506676797 0.9260700020333597 0.97828792864324 1.0835387251868815 1.0 13.564154150860182 -6.271224379035006 24.989231341017994 0.9778695960156704 1.09177248060961 0.3089040799284567 0.08294233852624273 915.7936533813076 2338777.3502164283 0.027275434107623262 0.03130686034336864 5.355199086919995e-07 6.271224379035006 0.11390288459393971 KKLGAGEGGEASVS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 KKLGAGEGGEASVSPEK 17 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KKLGAGEGGEAS(0.036)VS(0.964)PEK 49.559 0.041934 33792000.0 271320.0 289120.0 231960.0 222040.0 222160.0 146800.0 160350.0 148560.0 86015.0 231730.0 True False 256241.12058001527 311294.57433267584 217035.94613895263 191797.7689596355 194250.27466440084 167020.36748228045 167806.5927274971 148992.28500456805 103220.4034599049 225039.35279315384 1.1386502733836987 1.3832895023423035 0.9644355240322896 0.852285462871587 0.863183582130842 0.7421829356032593 0.7456766589696756 0.6620721360744186 0.45867712548382816 1.0 17.779817783057688 -5.656964857041345 1.0056264250551146 0.7056522487065859 1.3095170253630317 0.6387381478255991 0.14781586392156415 0.40811343129698074 0.7397184328612911 0.05535711983265565 0.1967880955409501 2.2031047303103856e-06 5.656964857041345 0.6038647766564458 KKMIST(ph)T(ph)S(ph)KET(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KKMISTTSKETK 12 3 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;J3KSK9;J3QQQ8 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 4 KKMIS(0.234)T(0.9)T(0.9)S(0.966)KET(1)K 54.237 0.043844 0.0 2578.8 3729.1 2674.6 2701.6 1770.6 2462.1 2908.8 3225.9 2497.1 3790.0 True False 2638.881022528696 3292.495238388443 2311.404010526172 2229.8162753128163 1610.4495426248197 2437.3335094079357 2689.3868741116835 3140.338652800027 4237.396319031968 4276.483417726242 0.6170679889907674 0.7699071682917984 0.5404917509899102 0.5214135207610333 0.37658266975838706 0.5699387256606828 0.6288781251820217 0.7343273306715427 0.9908599905865985 1.0 12.062209230549323 -8.070705535159343 1.8445961572173843 1.0151433768050466 0.56652155096518 0.7663744413383604 0.09236569388770638 0.18758922304356904 1.1396784800042246 0.09198986084015479 0.029352397879569534 8.497564404120835e-09 8.070705535159343 -0.44862182583986665 KKPAPGPHS(ph)SPPEEK ddPTM_A459_Selumetinib_30min_R2 1 KKPAPGPHSSPPEEK 15 2 M0QYC5;O75182-2;O75182 M0QYC5 SIN3B Paired amphipathic helix protein Sin3b 1 KKPAPGPHS(0.5)S(0.5)PPEEK 59.68 0.033821 11851000.0 107920.0 83793.0 96724.0 95172.0 94989.0 74565.0 91473.0 95678.0 73417.0 104820.0 True False 101922.23843798928 90219.65366303934 90500.88314512862 82209.40941914257 83055.63260756563 84835.65191632329 95726.67575031095 95956.40713965443 88102.45144237418 101793.57424493313 1.0012639716603973 0.8863000865452969 0.8890628295197464 0.807609026688977 0.8159221564194146 0.8334087150942738 0.9403999855627021 0.9426568214292834 0.8655011094352998 1.0 16.635286968094412 -9.871324803332959 7.2115098223543495 0.9999999998609298 0.8841686391621201 0.2531363234866786 0.058109076803976235 82502870.6566728 0.0 0.06041145140998277 0.015102862739970602 1.3448541784724595e-10 9.871324803332959 -0.11583136069880973 KKPAPLPPSS(ph)SPGPPSQDSR ddPTM_A459_Selumetinib_30min_R2 2 KKPAPLPPSSSPGPPSQDSR 20 2 Q8N3F8 Q8N3F8 MICALL1 MICAL-like protein 1 1 KKPAPLPPS(0.014)S(0.544)S(0.439)PGPPS(0.002)QDS(0.001)R;KKPAPLPPS(0.048)S(0.469)S(0.469)PGPPS(0.012)QDS(0.002)R 71.042 0.004007500000000001 23057700.0 87769.0 89401.0 100978.0 104768.0 94055.0 73558.0 82446.0 76506.0 75345.0 85930.0 True False 82891.15034714507 96257.76923047693 94481.18541653357 90498.41766511938 82238.97003763156 83689.946806959 86279.90236364969 76728.61979374982 90416.105315195 83448.9776270471 0.9933153491419021 1.153492492870018 1.1322030311598539 1.084476050378686 0.9855000309911123 1.0028876229135943 1.0339240194080583 0.9194674635400313 1.0834896710093396 1.0 16.348606754105276 -6.189366570577301 5.092987623071043 1.0016510818634523 1.099952647060613 0.3711914096347908 0.05489927812635716 0.21368294428686807 10.421359132773068 0.015793136798418553 0.02046583339518759 6.465966190461372e-07 6.189366570577301 0.0983015651971606 KKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPT(ph)EFLEEK ddPTM_A459_Selumetinib_30min_R1 1 KKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEK 44 3 P27816;P27816-6;P27816-2;P27816-5;H7C456 P27816 MAP4 Microtubule-associated protein 4 1 KKPCS(0.001)ET(0.001)S(0.001)QIEDT(0.066)PS(0.066)S(0.066)KPT(0.066)LLANGGHGVEGS(0.066)DT(0.066)T(0.066)GS(0.258)PT(0.28)EFLEEK 47.022 0.0011569 55737000.0 2764.2 4620.1 4561.7 3740.7 4143.5 3375.0 3727.2 3404.7 1827.5 3175.3 True False 2828.600481803095 4079.1765441737834 3942.246195624483 3087.456966635567 3768.7211565943394 3341.0505642548164 3446.054303214062 3314.3962959757737 3101.134024681 3582.880685041195 0.7894766056856768 1.1385186677314325 1.100300719497489 0.8617247511271975 1.0518690092944045 0.9325039983061567 0.9618110694005542 0.9250646581153638 0.865542086742792 1.0 11.80690428523962 -7.068724653043002 1.3800054336419958 0.9252861280121047 0.997190981458151 0.03990639586466593 0.10330711284825987 1.2213138969572663 4.677346428387466 0.05618773968105448 0.03878504447826207 8.536411593449457e-08 7.068724653043002 0.07190485344604625 KKPGDASSLPDAGLS(ph)PGSQVDSK ddPTM_A459_Selumetinib_30min_R2 1 KKPGDASSLPDAGLSPGSQVDSK 23 2 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 KKPGDASSLPDAGLS(0.854)PGS(0.146)QVDSK 137.28 2.45e-06 0.0 19524.0 17405.0 21807.0 17839.0 23152.0 19356.0 24214.0 16480.0 15099.0 14962.0 True False 18438.934240764494 18739.907534104244 20403.96136166639 15409.29742600854 20243.438778493924 22022.113303726306 25339.998979130756 16527.954071589127 18119.221901309083 14530.008184055412 1.2690243534066667 1.2897382641992308 1.4042635835578394 1.0605153989464384 1.3932159240425053 1.5156297935119127 1.7439769240417737 1.1375048012516726 1.2470207636353787 1.0 13.826747895121224 -8.446543204683081 1.8005711840728023 1.0180918436250144 1.3668140886063427 0.26916707161304143 0.17941039764364214 0.48053181180268156 3.375414151388787 0.1806447877290753 0.05182142705633616 3.5764881902258434e-09 8.446543204683081 0.3487222449813283 KKS(ph)GPPAPEEEEEEER ddPTM_A459_Selumetinib_30min_R2 2 KKSGPPAPEEEEEEER 16 2 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 KKS(1)GPPAPEEEEEEER;KKS(1)GPPAPEEEEEEER 73.833 0.013171 5302500.0 25071.0 18340.6 25687.0 22433.2 22345.3 22929.5 29118.0 25459.0 19078.7 24626.0 True False 23677.654187164873 19747.26504567609 24034.326385890974 19377.759460571506 19538.083644483417 26087.830491723118 30472.044696222394 25533.081475035666 22894.97310341782 23914.98339396794 0.9900761291407407 0.8257277339635087 1.0049903021029543 0.8102769356494366 0.8169808576748372 1.090857144324977 1.274182139047955 1.0676604308860134 0.9573484842641622 1.0 14.545627169098697 -6.774759089864991 24.725413852223525 1.0944992731023682 0.8880639449077679 0.4667093122058379 0.09991379870177536 175.27062734792827 325353.16670560837 0.03592133647814656 0.03186631867243405 1.679735536056124e-07 6.774759089864991 -0.2064353281946003 KKS(ph)PNELVDDLFK ddPTM_A459_Selumetinib_30min_R1 6 KKSPNELVDDLFK 13 2 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 1 KKS(1)PNELVDDLFK;KKS(1)PNELVDDLFK;KKS(1)PNELVDDLFK;KKS(1)PNELVDDLFK;KKS(1)PNELVDDLFK;KKS(1)PNELVDDLFK 120.32 0.001197 1287907700.0 62241.99999999999 79845.9 84217.1 88693.59999999999 63070.8 69580.6 66816.40000000001 64051.799999999996 42127.6 62844.700000000004 True False 63692.11749815075 70497.5049086481 72780.88039141695 73204.92774507131 57366.05727605416 68880.68233813006 61776.38515380777 62352.938194431554 71487.46032183366 70911.42940421648 0.8981925485535839 0.9941627957714844 1.0263631829580537 1.0323431407337906 0.8089818208155187 0.9713622037639299 0.8711767013137444 0.8793073093901554 1.0081232450460647 1.0 16.113730557308507 -6.210438564294575 24.99991924010718 0.9169345773727641 0.9909793471541892 0.17824012014093404 0.06702502044731819 549.3517218665595 269284.5191064305 0.019266117879996547 0.02487243809718819 6.159726590234996e-07 6.210438564294575 0.07404476978142516 KKS(ph)PNELVDDLFK ddPTM_A459_Selumetinib_30min_R2 1 KKSPNELVDDLFK 13 2 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 1 KKS(1)PNELVDDLFK 122.42 0.0010372 63062000.0 81722.0 75021.0 73902.0 81977.0 69462.0 57407.0 72167.0 64984.0 42499.0 75978.0 True False 77180.21839908606 80774.8694694649 69147.22577841385 70811.59118178733 60735.56256184102 65314.29316113951 75522.90849619766 65173.09268131968 50999.98752127524 73784.31772544862 1.0460246943838878 1.0947430559706213 0.9371534210794035 0.9597105911486122 0.8231500193284702 0.8852056260000117 1.0235631476219422 0.8832919337118315 0.6912036201384438 1.0 16.171026594969135 -5.479745631546946 1.739425339196487 0.8885545079244677 1.0769438968772798 0.36773247199093195 0.08982927788683799 0.4298934970991849 2.4670481592678257 0.027274672844368728 0.08354669316326226 3.313251234472065e-06 5.479745631546946 0.1883893889528121 KKS(ph)PVPVETLK ddPTM_A459_Selumetinib_30min_R2 2 KKSPVPVETLK 11 2 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 KKS(1)PVPVETLK;KKS(1)PVPVETLK 76.868 0.019789 17930700.0 129510.0 114794.0 126792.0 131399.0 135618.0 101026.0 117136.0 129215.0 96094.0 134571.0 True False 122312.35266960727 123598.33067911296 118634.34076069178 113502.22952408213 118580.4543996972 114941.41447728103 122583.05610058074 129590.9942573052 115315.48509069414 130685.58557255214 0.9359284127146804 0.9457686564100477 0.9077844372884573 0.8685137616885038 0.9073721013697063 0.8795263377648448 0.9379998227312288 0.9916242383545868 0.8823887086359264 1.0 16.995740497208892 -7.512649174895192 24.30090165577673 0.9551662902236054 0.907568589511559 0.2843469923708941 0.036347045599293734 475.41892076943583 1129394.281227038 0.01605747647705176 0.010004858377288104 3.071502160256843e-08 7.512649174895192 -0.04759770071204639 KKTEFLDLDNSPLSPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 KKTEFLDLDNSPLSPPSPR 19 2 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 KKTEFLDLDNSPLS(0.001)PPS(0.999)PR;KKTEFLDLDNSPLS(0.002)PPS(0.998)PR;KKTEFLDLDNSPLSPPS(1)PR 104.97 0.00068931 158131000.0 13702.5 14839.2 19804.4 21231.6 17324.7 15534.0 15739.5 13617.5 8589.5 11735.3 True False 14021.741589576337 13101.819565443078 17115.07125778229 17523.89962649229 15757.683943924207 15377.742063743508 14552.256843055846 13256.319664126091 14575.754147741418 13241.640066502046 1.0589127569663932 0.9894408471792948 1.2925189909880597 1.3233934420875297 1.1900099885502178 1.1613170261775392 1.0989769220407466 1.0011085936145614 1.100751423127286 1.0 13.69279420028019 -7.42190178651634 2.744586308726805 1.0383104474237095 1.175433646704278 0.28651956701207937 0.09550394864148005 0.41675557216210246 6.094291238709674 0.05322546221998065 0.0319272824047745 3.785281772566525e-08 7.42190178651634 0.1371231992805686 KKTEFLDLDNSPLSPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 KKTEFLDLDNSPLSPPSPR 19 2 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 KKTEFLDLDNSPLSPPS(1)PR 88.976 0.0011803 7633400.0 213610.0 250350.0 253520.0 275700.0 274430.0 206150.0 183360.0 188190.0 170100.0 248740.0 True False 201738.41134858155 269551.0399978741 237208.79921170548 238149.184390972 239953.64996467205 234545.29125662238 191886.60332094695 188737.60174346823 204124.7529911036 241558.2298958658 0.8351543701721513 1.1158843154053406 0.9819942765517228 0.9858872723717034 0.9933573783352962 0.970967916753378 0.7943699678693126 0.7813337671203825 0.8450333200367484 1.0 17.882011480705827 -7.187599818941048 5.915323672467889 0.8372754676741483 0.9887406788203094 0.3358037018780228 0.08457102424169703 0.21458828921170506 13.334029899391115 0.031046509768197533 0.023852299968015425 6.492323938105075e-08 7.187599818941048 0.15146521114616107 KKVEEEDEEEEEEEEEEEEEEDE ddPTM_A459_Selumetinib_30min_R1 2 KKVEEEDEEEEEEEEEEEEEEDE 23 2 O15347 O15347 HMGB3 High mobility group protein B3 0 ; 87.85 0.00090315 29094800.0 2408.7 2647.8999999999996 3173.3 2934.9 1840.7800000000002 2401.9 1946.9099999999999 2163.5 1431.6 1904.76 False True 2464.8180234856795 2337.8826370246866 2742.3832896891895 2422.374809896202 1674.2817740161047 2377.7390667507098 1800.0530112337674 2106.1169519615783 2429.320640072951 2149.2544999335714 1.1468246424803863 1.0877644490668485 1.2759695465446044 1.127076765441725 0.7790058246093484 1.1063087534883376 0.8375243654436471 0.9799290647183354 1.1303085047154888 1.0 11.069620611565796 -6.0234021640299895 24.776008247210658 0.9695033590601504 1.1685405699344853 0.4203680837899151 0.10856236220348489 624.3349940859774 660986.7671140098 0.030843232477193845 0.04009880663198519 9.475406182876255e-07 6.0234021640299895 0.1990372108743349 KKVEEEDEEEEEEEEEEEEEEDE ddPTM_A459_Selumetinib_30min_R2 1 KKVEEEDEEEEEEEEEEEEEEDE 23 2 O15347 O15347 HMGB3 High mobility group protein B3 0 74.793 0.0038557 6987900.0 28445.0 25930.0 27022.0 25553.0 26090.0 15373.0 14799.0 15119.0 10872.0 21194.0 False True 26864.140774357016 27918.747621908828 25283.433939329043 22072.6373186163 22812.34095244068 17490.4912078004 15487.18282366217 15162.993786914813 13046.703789061012 20582.074151374825 1.3052202891107827 1.3564593838587415 1.228420117106622 1.0724204546285685 1.1083596718514825 0.8497924494471849 0.7524597720209685 0.7367087337940607 0.6338867352778208 1.0 14.329100756199214 -6.398493200415104 0.9247902307795771 0.7455174324303718 1.3286384074221689 0.8193718430622191 0.10203572538314613 0.21537539310669315 0.39867742932524597 0.0512039213145577 0.07018324321180887 3.994908159363471e-07 6.398493200415104 0.583120974991797 KKYTNSGT(ph)VT(ph)LLS(ph)FLVETEVS(ph)FLDY(ph)IK ddPTM_A459_Selumetinib_30min_R2 1 KKYTNSGTVTLLSFLVETEVSFLDYIK 27 2 E7ENV7;Q86YQ8 E7ENV7 CPNE8 Copine-8 5 KKY(0.246)T(0.255)NS(0.255)GT(0.623)VT(0.623)LLS(0.521)FLVET(0.514)EVS(0.971)FLDY(0.991)IK 41.208 0.035955 35824000.0 1984.2 3709.4 4565.0 4496.4 4650.6 8749.4 2883.8 3188.7 2920.0 9698.7 True False 1873.9261073819353 3993.899052399096 4271.292869996192 3883.9825632773614 4066.350051108493 9954.550430854662 3017.9024141412915 3197.9785890822977 3504.0815916168285 9418.673330751111 0.19895860505786278 0.42404051103029333 0.4534919855486239 0.41237045036868536 0.4317327831969955 1.0568951784699827 0.32041693221147344 0.33953599161796905 0.3720355795944553 1.0 13.201308147691556 -4.652891085443486 0.7911197676052169 0.5498855696095543 2.688794421676082e-13 0.1696513179067375 0.2487846029947536 6.77335922782666 2.828655422629799 0.09694042673026347 3.4482739748191045 2.22386753341976e-05 4.652891085443486 -0.5498855696092854 KLANDFPLDLS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 KLANDFPLDLSPVK 14 1 Q96JM2;Q96JM2-3 Q96JM2 ZNF462 Zinc finger protein 462 1 KLANDFPLDLS(1)PVK 114.4 0.0015344000000000002 20421000.0 4760.9 5669.1 5439.9 5689.8 4700.0 4297.5 3813.0 4388.4 3151.9 3834.1 True False 4871.819706901224 5005.359136506914 4701.191459231784 4696.183240773931 4274.885829852398 4254.271051817801 3525.3823401360874 4272.005376467847 5348.544094332168 4326.24408229662 1.1261083781280739 1.1569756678753504 1.086668105128299 1.0855104685357757 0.9881286743264477 0.9833636223223421 0.814882903755308 0.9874628650633184 1.2363019729328013 1.0 12.078899347646937 -6.014033000271062 1.8685337991169193 0.9900555717037545 1.132578749996211 0.2444142183118735 0.09694703955041448 0.48848652458799563 3.422826919284437 0.03357093191301093 0.053735106620758165 9.682042835609817e-07 6.014033000271062 0.14252317829245653 KLATPPAAQESS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 KLATPPAAQESSR 13 1 H0Y760;Q9Y4B4 H0Y760 RAD54L2 Helicase ARIP4 1 KLAT(0.019)PPAAQES(0.221)S(0.76)R 93.228 0.031238 3039000.0 1850.4 2373.0 2403.4 2683.7 2013.1 2001.7 1836.0 2009.5 1171.4 1780.9 True False 1893.510719748371 2095.168056822229 2077.0314809312063 2215.0421742882 1831.015460441672 1981.564715398184 1697.509041827919 1956.201532224078 1987.7802443290395 2009.4958624350045 0.9422814722563855 1.042633675435097 1.0336082396379584 1.1022875019031515 0.9111815031173744 0.9861004207279258 0.8447437357601544 0.9734787559371497 0.9891934994682442 1.0 10.97261789154337 -6.277170520061154 24.98698446302952 0.9459208324937907 1.0313339037023022 0.320985015108606 0.056313547447279136 913.8006990527438 1451457.3942291427 0.017379973246138766 0.01977385010101154 5.282378053710486e-07 6.277170520061154 0.08541307120851149 KLCQPQSTGSLLGDPAAS(ph)SPPGER ddPTM_A459_Selumetinib_30min_R1 2 KLCQPQSTGSLLGDPAASSPPGER 24 1 U3KQ90;P55199 U3KQ90 ELL RNA polymerase II elongation factor ELL 1 KLCQPQSTGSLLGDPAAS(0.746)S(0.254)PPGER;KLCQPQSTGSLLGDPAAS(0.75)S(0.25)PPGER 173.99 8.4222e-17 66807000.0 3630.8 3973.3 5265.8 5379.5 4858.2 4679.799999999999 3861.5 3522.3999999999996 2020.38 3220.2 True False 3715.390575693031 3508.104188862944 4550.7332829689385 4440.071310721531 4418.776667784875 4632.7254609184265 3570.2239460885135 3428.974509632291 3428.4372972831734 3633.5440374042337 1.022525263887339 0.9654772730838009 1.2524227685485643 1.2219671111770731 1.2161065401429958 1.2749881144217527 0.9825734625302751 0.9436997252087564 0.943551877172903 1.0 11.827161676097727 -7.3839974745210775 6.806513843297034 0.9591580912404285 1.1594810388176162 0.5010400346604656 0.09367924537127215 0.23590842037567228 12.137005087277101 0.044377250545306536 0.029711426771794707 4.130499039221148e-08 7.3839974745210775 0.20032294757718772 KLCQPQSTGSLLGDPAAS(ph)SPPGER ddPTM_A459_Selumetinib_30min_R2 2 KLCQPQSTGSLLGDPAASSPPGER 24 1 U3KQ90;P55199 U3KQ90 ELL RNA polymerase II elongation factor ELL 1 KLCQPQSTGSLLGDPAAS(0.737)S(0.263)PPGER;KLCQPQSTGSLLGDPAAS(0.768)S(0.232)PPGER 192.77 6.2534e-27 46049000.0 120589.0 123040.0 147821.0 136199.0 140730.0 111264.0 88584.0 86092.0 72898.0 138445.0 True False 113887.1461360148 132476.77236404433 138310.35779533596 117648.46124362003 123050.23925783725 126589.60604597046 92703.3315258659 86342.51346670213 87479.63694030257 134447.7331266908 0.8470737548895552 0.9853403198640084 1.0287295633687286 0.8750497945008807 0.9152273258626561 0.941552550586215 0.6895120458335365 0.6422013332522397 0.6506590695573131 1.0 17.036685905107234 -7.258174138065198 24.65004695526205 0.7157765502082702 0.9356030507133626 0.41162204629575716 0.10687723802926348 194.50961711072466 1468404.4451586648 0.04035166358316809 0.02992978920630149 5.5185611842672746e-08 7.258174138065198 0.21982650050509234 KLDEAVAEAHLGK ddPTM_A459_Selumetinib_30min_R1 2 KLDEAVAEAHLGK 13 1 P23526-2;P23526 P23526-2 AHCY Adenosylhomocysteinase 0 ; 98.942 0.008196 20710000.0 14214.2 15322.2 17617.3 18179.1 15867.6 14350.599999999999 13400.2 13532.7 8813.7 11266.400000000001 False True 14545.363203981477 13528.269700902476 15224.967424901943 15004.46144897069 14432.37838165231 14206.245993302266 12389.412125437088 13173.768835595316 14956.205172821303 12712.552184029268 1.1441733330506807 1.0641663062668085 1.1976326393396453 1.1802871077155332 1.1352856745621587 1.1174975557740106 0.9745810240214282 1.0362804136328716 1.176491152705806 1.0 13.633966075794326 -7.0390594462484515 10.854256412122725 1.049269565428973 1.1429953805616204 0.37853717401065323 0.05916989857151126 0.9954321578323292 274.221798840567 0.022932955586942704 0.0178861317049408 9.139881261712378e-08 7.0390594462484515 0.09372581513264744 KLDELYGTWR ddPTM_A459_Selumetinib_30min_R1 1 KLDELYGTWR 10 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 105.13 0.017179 19675000.0 6767.4 6843.6 8025.0 8039.0 7615.5 4851.8 5112.0 4692.0 3038.8 4361.2 False True 6925.067252931868 6042.348130496677 6935.249078169646 6635.13956071947 6926.6793696257255 4802.995297081932 4726.397724305191 4567.552918236067 5156.621654829338 4921.002501685403 1.4072472530871685 1.227869347440328 1.4093163081698048 1.348330865194031 1.4075748523300677 0.9760196820540012 0.9604542413230716 0.9281752888098954 1.0478803156599161 1.0 12.264736534551844 -6.766261221060093 24.99979101352173 0.9766385605546647 1.3548073741805853 0.9154345981610713 0.057352385557675176 31.192553249419905 161722.83714139526 0.01936684685402816 0.017625254097559755 1.7129267000708587e-07 6.766261221060093 0.3781688136259206 KLDFNS(ph)PGGSSPVENSDCSTNSR ddPTM_A459_Selumetinib_30min_R2 2 KLDFNSPGGSSPVENSDCSTNSR 23 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 KLDFNS(0.91)PGGS(0.065)S(0.025)PVENSDCSTNSR;KLDFNS(0.983)PGGS(0.016)S(0.001)PVENSDCSTNSR 108.75 9.0468e-06 7538900.0 38727.0 41408.0 40790.0 45247.0 50923.0 39039.0 38779.0 39028.0 34292.0 37083.0 True False 36574.70837646419 44583.86045229467 38165.61580879403 39084.28054457138 44525.59748260391 44416.26788924215 40582.30033913071 39141.565018566806 41151.358198535716 36012.31743679499 1.0156166273013738 1.2380169793444575 1.0597933852987462 1.0853031219989653 1.2363991170729438 1.233363222658383 1.126900550356318 1.0868938131311305 1.1427023065305426 1.0 15.136202821260229 -9.249637238154122 0.9139792027402388 0.999196073847315 1.14334245498919 0.2275731187872665 0.07460074605001564 4.910731683584262 4.959011835527942 0.08536481977522976 0.023985522053260634 5.628112395163924e-10 9.249637238154122 0.14414638114187495 KLDFNSPGGSS(ph)PVENSDCSTNSR ddPTM_A459_Selumetinib_30min_R2 2 KLDFNSPGGSSPVENSDCSTNSR 23 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 KLDFNSPGGS(0.261)S(0.739)PVENSDCSTNSR;KLDFNSPGGS(0.004)S(0.996)PVENSDCSTNSR 129.37 4.2808e-06 13990800.0 44360.0 41671.0 51518.0 56823.0 54260.0 39533.0 41479.0 41985.0 42237.0 47868.0 True False 41894.64878714984 44867.031706616384 48203.38796855726 49083.60937485755 47443.37370944539 44978.31190515668 43407.855689079224 42107.16939900908 50685.580200383556 46485.92646399974 0.9012329531518417 0.9651745188162038 1.0369458379169356 1.0558810613975724 1.0205964970104904 0.9675683658792816 0.9337848891254371 0.9058046725522031 1.0903424768706325 1.0 15.504506388377452 KLDPAQS(ph)ASRENLLEEQGSIALR ddPTM_A459_Selumetinib_30min_R1 1 KLDPAQSASRENLLEEQGSIALR 23 2 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 KLDPAQS(0.914)AS(0.086)RENLLEEQGSIALR 58.51600000000001 0.0055267 7663400.0 1288.9 1674.5 2005.3 1986.1 1897.1 1615.3 1896.8 1779.8 932.81 1399.9 True False 1318.9288622371791 1478.4487615460705 1732.9912743244347 1639.2649187143852 1725.5076399602085 1599.051548575053 1753.7228488775584 1732.5939223948308 1582.910440253178 1579.59080118073 0.8349813516584749 0.9359694678146664 1.0971140582922103 1.0377782128694655 1.092376353844557 1.012320119476371 1.1102387071174802 1.0968625045801306 1.0021015816691048 1.0 10.6253351559969 -5.018162957233336 3.0349941083782253 1.0603892146452458 0.8382686674095929 0.7530498021068471 0.04085362593035724 0.11764646300899208 2.065336012063242 0.010186136037489227 0.04806844318358806 9.590407099619136e-06 5.018162957233336 -0.2221205472356529 KLDPAQSAS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 KLDPAQSASR 10 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 KLDPAQS(0.023)AS(0.977)R 77.64399999999998 0.027976 8450800.0 67710.0 53766.0 49787.0 57749.0 77583.0 61799.0 64696.0 67452.0 62538.0 47043.0 True False 63946.94926460579 57889.679315061716 46583.75862398697 49883.486577418465 67836.32993918001 70311.25129453318 67704.49219269196 67648.27415272032 75047.34745771678 45684.7463576072 1.399743992536311 1.2671555372534582 1.0196786091213588 1.0919068300597474 1.4848792069058787 1.5390531172955786 1.481993391464198 1.4807628266815553 1.642722209077566 1.0 15.479424924971338 -6.271818211505447 24.3999501066249 1.4695020988130687 1.1873063613195083 0.28356752003097807 0.1856070727031579 568.4635641572901 1336417.457104497 0.055912164067308014 0.06410647751939887 5.347881660431629e-07 6.271818211505447 -0.2821957374935604 KLDPEEEDDS(ph)FNNYEVQSEAK ddPTM_A459_Selumetinib_30min_R1 1 KLDPEEEDDSFNNYEVQSEAK 21 1 A0A087WWW8;Q9Y6J0-2;Q9Y6J0 A0A087WWW8 CABIN1 Calcineurin-binding protein cabin-1 1 KLDPEEEDDS(0.991)FNNY(0.009)EVQSEAK 89.859 0.0032403 0.0 766.04 887.53 800.94 1009.4 716.41 737.72 615.63 945.73 330.3 514.25 True False 783.8872415456349 783.6175749984966 692.1767472484979 833.1272387847036 651.6108419924584 730.2992065961669 569.1925334534433 920.6461682360178 560.4949758424813 580.2589967191872 1.3509264758974386 1.3504617411002824 1.1928755110426537 1.4357851295632569 1.1229655131186214 1.258574551580095 0.9809284072658688 1.5866124841517262 0.9659393116031761 1.0 9.180553176015803 -14.522878741153521 0.05827579556135624 0.0167950805946602 1.6791307567390497 0.2286463568189182 0.17492042285175494 669.3898423491648 2.845298664254738 94.49183465406482 16.489652909028642 3.000000028507038e-15 14.522878741153521 1.6623356761443895 KLDPEEEDDS(ph)FNNYEVQSEAK ddPTM_A459_Selumetinib_30min_R2 1 KLDPEEEDDSFNNYEVQSEAK 21 1 A0A087WWW8;Q9Y6J0-2;Q9Y6J0 A0A087WWW8 CABIN1 Calcineurin-binding protein cabin-1 1 KLDPEEEDDS(0.995)FNNY(0.005)EVQSEAK 72.883 0.0021899000000000003 5179300.0 31707.0 31390.0 39927.0 36941.0 35766.0 24715.0 32390.0 33218.0 23420.0 27359.0 True False 29944.851873177617 33797.51206524172 37358.140289230665 31909.572073220555 31272.75532790313 28119.266909567865 33896.19917956741 33314.658880464085 28104.654409474704 26569.07458278118 1.1270566379675189 1.2720620720130436 1.4060760819062037 1.2010042718574938 1.177035926880581 1.058345740343976 1.275776432256123 1.2538885679539085 1.0577957588213742 1.0 14.697460358296832 -5.991380782475141 24.884964633190318 1.1561171786560276 1.2745605777712017 0.23327457183207634 0.10342827824199509 296.2710292378225 855368.8159601939 0.029306247876113977 0.04339568041590207 1.020044732560485e-06 5.991380782475141 0.1184433991151741 KLDVEEPDSANS(ph)SFYSTR ddPTM_A459_Selumetinib_30min_R1 2 KLDVEEPDSANSSFYSTR 18 1 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 KLDVEEPDS(0.019)ANS(0.482)S(0.482)FYS(0.012)T(0.005)R;KLDVEEPDSANS(0.509)S(0.483)FYS(0.007)T(0.002)R 196.98 1.2931e-10 33502000.0 6725.1 8373.9 8368.2 8864.7 6890.0 8346.7 8974.599999999999 8755.8 6085.8 7921.3 True False 6881.781745233343 7393.479895079506 7231.844403232303 7316.646556028098 6266.800716528297 8262.739776197242 8297.63869650809 8523.56774115331 10327.158110754379 8938.076014996004 0.7699399438634579 0.827189194036275 0.8091052695344007 0.8185930108171461 0.7011353121202 0.9244427729563157 0.92834729561335 0.9536244407468402 1.1554117567838782 1.0 13.125748599029317 -7.471772630840555 1.2156732650605016 1.0612951484292106 0.7935189132300918 0.7501078215432063 0.0622171540216862 0.2344833865491477 0.6540045895055777 0.045003563315050836 0.02162550007601051 3.37463937221398e-08 7.471772630840555 -0.26777623519911875 KLDVEEPDSANS(ph)SFYSTR ddPTM_A459_Selumetinib_30min_R2 1 KLDVEEPDSANSSFYSTR 18 1 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 KLDVEEPDSANS(0.48)S(0.48)FYS(0.019)T(0.019)R 106.47 0.00085151 6962300.0 74159.0 80222.0 86857.0 85092.0 85176.0 69365.0 69672.0 65829.0 62580.0 73823.0 True False 70037.5396619982 86374.7694456138 81268.71518275139 73502.32280811237 74475.4293968986 78919.39911722341 72911.88605244886 66020.55149142236 75097.74863129498 71691.53817481085 0.9769289576577423 1.204811218236101 1.1335886668324482 1.0252579966813677 1.0388315175397629 1.1008188849957206 1.0170222024621978 0.9208974053596047 1.047512029218546 1.0 16.1295152257617 -6.969710675493564 0.8731509628101275 0.985836872164969 1.1000892273432137 0.2396088086700391 0.06740753131008377 0.7887895453191153 1.2586863253976304 0.04743795656479692 0.035919277408418396 1.0722333831172298e-07 6.969710675493564 0.11425235517824472 KLDYGQHVVAGT(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 KLDYGQHVVAGTPGR 15 1 I3L3H2;P38919 I3L3H2 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 KLDYGQHVVAGT(1)PGR 64.65 0.037916000000000005 11368000.0 104220.0 100290.0 121390.0 115530.0 120000.0 107980.0 80248.0 91283.0 82429.0 119820.0 True False 98427.86962571586 107981.92051682365 113579.89955943855 99794.61469963382 104924.52718638862 122853.2648551542 83979.69100839536 91548.61841728582 98917.10325869301 116360.4852702526 0.8458874109807345 0.9279947592692713 0.9761036944426967 0.8576331945321147 0.9017195738114753 1.055798835573965 0.7217200135711762 0.7867672449514105 0.8500918763698301 1.0 16.828241692621624 -7.271893224755009 24.99775130540677 0.8218753993272524 0.9254028953546235 0.18725518803989538 0.08651299117588708 1034.5908406881545 2473955.1766460724 0.03491292219370033 0.02382500192292052 5.346958030601864e-08 7.271893224755009 0.1035274960273711 KLEAAEDIAYQLSR ddPTM_A459_Selumetinib_30min_R1 1 KLEAAEDIAYQLSR 14 1 P35232 P35232 PHB Prohibitin 0 134.02 0.00091807 9950400.0 4101.3 3997.4 4391.5 5001.9 4152.6 4064.1 3374.2 3924.8 2019.2 3206.2 False True 4196.8523102594 3529.3825496591576 3795.1584207828055 4128.412062291668 3776.998063201078 4023.2188439075544 3119.6813774159955 3820.701554452878 3426.43492346696 3617.747001032684 1.1600734681174252 0.9755747288717805 1.0490392002811362 1.1411555482219224 1.0440194027174747 1.1120785513080735 0.8623271269454399 1.056099708841514 0.947118447610871 1.0 11.820875804528942 -7.231955271343781 24.988998991018462 0.9710612482059883 1.0752550750002987 0.4074557496208149 0.06705034135274664 739.0816218956192 626402.9384295003 0.024582671339323434 0.019038598781839885 5.861985348932748e-08 7.231955271343781 0.10419382679431044 KLEAAEER ddPTM_A459_Selumetinib_30min_R2 1 KLEAAEER 8 1 A2A2D0;P16949;P16949-2;E5RGX5;Q93045;Q93045-2;E5RIR6;E7EVN3;Q9H169-3;Q9H169;Q9H169-4;Q9H169-2 A2A2D0 STMN1;STMN2;STMN4 Stathmin;Stathmin-2;Stathmin-4 0 85.86200000000002 0.046922000000000005 3638700.0 36483.0 33229.0 24675.0 29450.0 28188.0 27024.0 39512.0 61203.0 37223.0 56399.0 False True 34455.42091302043 35777.557451924746 23087.43736410868 25438.859195916346 24646.7714360827 30746.31070055279 41349.38629154268 61381.090597297945 44668.64009751825 54770.61432779985 0.6290858946150607 0.6532254182470467 0.42152964043695634 0.4644618196842897 0.4499999085015333 0.5613650874269439 0.7549556783144392 1.1206938492589233 0.815558500588989 1.0 15.741114441816572 -7.452449944543328 2.974522693164707 0.975540324415726 0.5232723149053423 0.8008202269110007 0.10015834431520536 0.11413512715912445 1.9763860114913336 0.05036824269152562 0.03002943909945214 3.528174489380131e-08 7.452449944543328 -0.4522680095103837 KLEDSTRET(ph)QS(ph)QLET(ph)ERS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 KLEDSTRETQSQLETERSR 19 3 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 4 KLEDS(0.01)T(0.011)RET(0.98)QS(1)QLET(1)ERS(1)R 55.63399999999999 0.043315 0.0 29669.0 23384.0 27167.0 29707.0 31817.0 24130.0 34506.0 36911.0 33172.0 25865.0 True False 28020.115754417227 25177.47760858913 25419.10479719313 25660.855352566618 27819.86401241106 27453.68846966915 36110.59737234187 37018.40489905499 39807.32690312105 25118.210244659356 1.115529947456144 1.0023595376960577 1.0119791398193965 1.021603653390179 1.1075575744225699 1.0929794838987925 1.4376262090576186 1.4737676187309507 1.5847994946847337 1.0 14.616446050660251 -7.216132953199475 4.647004121284028 1.414766080250642 1.0509157246602394 0.5163533212819675 0.14761745268715962 0.14593696935733516 7.24584070940388 0.05604347326526258 0.041798764691568784 6.079488577224923e-08 7.216132953199475 -0.3638503555904027 KLEESASFESLSPS(ph)SRPASPTR ddPTM_A459_Selumetinib_30min_R2 1 KLEESASFESLSPSSRPASPTR 22 2 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 KLEESAS(0.001)FES(0.002)LS(0.011)PS(0.389)S(0.389)RPAS(0.105)PT(0.105)R 52.927 0.013734 5080500.0 16343.0 18173.0 19771.0 24944.0 26181.0 13367.0 18398.0 19109.0 15399.0 21451.0 True False 15434.72148621257 19566.810664595036 18498.955385037178 21546.58416919992 22891.908718890354 15208.182916455346 19253.543454945397 19164.604026334757 18479.230284009434 20831.653893608644 0.7409263597139588 0.9392826303915469 0.8880214446493295 1.0343194198234362 1.0989002042662497 0.7300516317200031 0.9242445920653748 0.9199751553195037 0.8870745634689642 1.0 14.34648976378572 -4.760329223989912 24.928366246154944 0.9331600542597057 0.740926122324234 0.2795889949147443 0.09374209631643518 37.99685354450335 852816.5548973065 0.023848506805927303 0.14235618956642299 1.7364839597894174e-05 4.760329223989912 -0.19223393193547167 KLEEVLS(ph)TEGAEENGNSDK ddPTM_A459_Selumetinib_30min_R1 1 KLEEVLSTEGAEENGNSDK 19 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 KLEEVLS(0.715)T(0.285)EGAEENGNSDK 53.589 0.033280000000000004 4013500.0 1336.0 1887.7 1691.2 1677.6 1554.1 1698.8 1668.9 1958.1 1106.7 2044.6 True False 1367.1262005965327 1666.6872064320792 1461.5443290966361 1384.6386524521683 1413.5319293986392 1681.7116143869887 1543.0135293609017 1906.1648271948086 1877.9890698300737 2307.044326090521 0.59258774750689 0.7224339764881846 0.6335137615553945 0.6001786080974674 0.6127025447291631 0.7289463819001646 0.6688269973449825 0.8262367591458305 0.8140238349960458 1.0 11.171830007979313 -8.283212292542306 0.7027699133926271 0.996956891532191 0.6347156108428479 0.8537828208736878 0.046959284253341366 0.23484270088982626 0.2624940609522112 0.0450929182051376 0.01884229128075192 5.209400021086429e-09 8.283212292542306 -0.36224128068934314 KLEEVLS(ph)TEGAEENGNSDK ddPTM_A459_Selumetinib_30min_R2 1 KLEEVLSTEGAEENGNSDK 19 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 KLEEVLS(0.5)T(0.5)EGAEENGNSDK 52.49800000000001 0.036949 7503900.0 31936.0 23877.0 30746.0 33464.0 31140.0 27666.0 27039.0 26824.0 21069.0 27686.0 True False 30161.124969937253 25708.28912334427 28767.835833713692 28906.145471380107 27227.91480486786 31476.74037305704 28296.36707676206 26902.053399047734 25283.38871704621 26886.633243133143 1.1217888345183722 0.9561736083081425 1.0699679492619631 1.0751121276503723 1.0126933543016912 1.1707207848753698 1.052432516220266 1.0005735249845211 0.9403702013714789 1.0 14.714601491118225 -7.847281330866653 3.5170410489408095 0.9707661460717827 1.0642342463241232 0.3378133222549613 0.05573785525606838 0.2769947663447624 6.628190111090403 0.03380161899316408 0.015020284016673748 1.4214077175942339e-08 7.847281330866653 0.09346810025234054 KLEEVLS(ph)TEGAEENGNSDKK ddPTM_A459_Selumetinib_30min_R1 1 KLEEVLSTEGAEENGNSDKK 20 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 KLEEVLS(0.942)T(0.058)EGAEENGNSDKK 83.82600000000002 0.017755 0.0 290.24 318.4 410.04 407.3 282.63 336.42 421.72 361.57 235.75 382.05 True False 297.0020272912707 281.12157997985577 354.3588201884962 336.17270096791157 257.06616640237934 333.0359202449201 389.90932087128016 351.97998905511787 400.05053150125633 431.08983898214007 0.6889562231216853 0.6521183163203774 0.8220068954192568 0.7798205166738785 0.5963169231948181 0.7725441198782643 0.9044734661153403 0.8164887158699659 0.9279980535978959 1.0 8.751844747598858 -7.818091681807894 0.7003980596857904 0.9920002439105482 0.7074217895223875 0.6556633940761392 0.07059881040598186 0.45586997822033315 0.4429287184260108 0.07016931082899032 0.033946818176101304 1.5202265681761395e-08 7.818091681807894 -0.28457845438816065 KLEEVLS(ph)TEGAEENGNSDKK ddPTM_A459_Selumetinib_30min_R2 1 KLEEVLSTEGAEENGNSDKK 20 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 KLEEVLS(0.965)T(0.035)EGAEENGNSDKK 114.75 0.0013796 0.0 7085.7 7329.8 7033.1 8801.2 8150.1 3365.0 7989.8 6779.9 4749.2 5197.8 True False 6691.9051603045 7891.972090978295 6580.5980030602905 7602.461377083157 7126.211575181556 3828.4982055713513 8361.341531488353 6799.628386527131 5699.172703735154 5047.72600849373 1.3257267032806725 1.5634707743048248 1.3036757526036915 1.5061160935222342 1.4117667169712445 0.7584599875526519 1.656457089275221 1.3470676449326888 1.1290574595659997 1.0 12.301417887352745 -13.76294167707251 0.08785486635029491 3.841536386194164e-08 1.653922492821934 0.2040571869616421 0.2303822345232557 314.2655220277239 2.2377742835414325 62.47579733400949 6.267170237413173 1.726069676370272e-14 13.76294167707251 1.6539224544065703 KLEGNSPQGS(ph)NQGVK ddPTM_A459_Selumetinib_30min_R2 2 KLEGNSPQGSNQGVK 15 1 P61006 P61006 RAB8A Ras-related protein Rab-8A 1 KLEGNS(0.001)PQGS(0.999)NQGVK;KLEGNS(0.002)PQGS(0.998)NQGVK 91.622 0.020136 2799600.0 20619.3 11343.0 17059.4 19207.2 14736.7 10536.2 19690.2 16471.2 15156.099999999999 11523.0 True False 19473.361851597794 12212.971626506436 15961.816776870332 16591.146225731896 12885.343998230457 11987.465911899217 20605.833315391108 16519.128465046044 18187.74349681638 11190.301049650485 1.740199996871936 1.0913890137824214 1.4263974406094178 1.4826362715460726 1.1514742937709361 1.0712371238907492 1.8414011583749756 1.4762005411429033 1.625313154321657 1.0 13.449961228821355 -7.249644383595583 24.99736133045432 1.5254121128273597 1.320086358026354 0.06721092889054858 0.27298122188849766 1665.6582638170487 3530067.097997514 0.10046688594789178 0.07717206103208085 5.628019796665668e-08 7.249644383595583 -0.20532575480100568 KLELDGEKETAPEEPGS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 3 KLELDGEKETAPEEPGSPAK 20 2 P35612 P35612 ADD2 Beta-adducin 1 KLELDGEKETAPEEPGS(1)PAK;KLELDGEKETAPEEPGS(1)PAK;KLELDGEKETAPEEPGS(1)PAK 58.5 0.013807 46535700.0 371757.0 282356.0 305967.0 281460.0 242473.0 226085.0 326722.0 302466.0 185731.0 258270.0 True False 351096.2342011827 304011.79728236306 286281.4163316816 243124.66245441773 212011.3740038769 257226.15655471 341915.2203873613 303346.1259840584 222882.38975773437 250813.0740339525 1.3998322677296118 1.2121050645119442 1.1414134507714209 0.9693460494069222 0.845296341988843 1.025569171565153 1.3632272627904412 1.2094510110864258 0.8886394404127548 1.0 17.9362530273309 -4.936635476856649 1.7268821998889832 1.0589042130449322 1.451478847983939 0.36877501984753414 0.1437372923678734 0.8449550674510942 3.2266514556936747 0.04467678114560146 0.5008812983591597 1.1570830272197963e-05 4.936635476856649 0.3925746349390067 KLENS(ph)PLGEALR ddPTM_A459_Selumetinib_30min_R1 3 KLENSPLGEALR 12 1 D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;D6RDK6;D6RBN5;Q9NX40-3;Q9NX40-2;Q9NX40-4;Q9NX40 D6RI08 OCIAD1 OCIA domain-containing protein 1 1 KLENS(1)PLGEALR;KLENS(1)PLGEALR;KLENS(1)PLGEALR 130.66 0.0038359 69040000.0 9130.4 11666.0 12267.3 12319.5 10399.7 10528.6 10175.8 11221.6 5583.21 8730.2 True False 9343.12055533427 10300.139296623744 10601.468039455514 10168.130590655996 9459.04897121616 10422.69184320393 9408.231213416417 10923.966715106104 9474.299588475622 9850.806209349243 0.9484625275103741 1.045613838880319 1.0762030857326004 1.032213036635071 0.9602309466040179 1.0580547035137002 0.9550722056116803 1.1089413884457844 0.961779105905435 1.0 13.266026087061862 KLENS(ph)PLGEALR ddPTM_A459_Selumetinib_30min_R2 1 KLENSPLGEALR 12 1 D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;D6RDK6;D6RBN5;Q9NX40-3;Q9NX40-2;Q9NX40-4;Q9NX40 D6RI08 OCIAD1 OCIA domain-containing protein 1 1 KLENS(1)PLGEALR 80.719 0.020334 45402000.0 96176.0 73814.0 86469.0 104000.0 83742.0 68857.0 79276.0 69251.0 59987.0 66436.0 True False 90830.92294303256 79475.29645058158 80905.67868032864 89835.02058999335 73221.58129702142 78341.42672838816 82962.4910824139 69452.50894487972 71986.07617682144 64517.82005854193 1.407842404790099 1.2318348074759435 1.2540051509322037 1.392406322911704 1.1349047632201754 1.2142602874260633 1.285884907567176 1.076485672979344 1.1157549357914294 1.0 15.977410072787857 -7.703869382824527 0.29346313835660504 0.9667030394189634 1.3667042199246842 0.6340278246819772 0.07580881850894626 1.0968488604231532 0.32766711989878283 0.14036370872405043 0.1592986956583553 1.9775643173106985e-08 7.703869382824527 0.40000118050572075 KLGAGEGGEASVS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 4 KLGAGEGGEASVSPEK 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KLGAGEGGEAS(0.002)VS(0.998)PEK;KLGAGEGGEAS(0.001)VS(0.999)PEK;KLGAGEGGEAS(0.009)VS(0.991)PEK;KLGAGEGGEAS(0.04)VS(0.96)PEK 185.96 1.7959e-08 209791000.0 13961.16 16681.42 13404.03 13060.5 11597.67 13289.32 13967.66 13320.74 7988.040000000001 13940.29 True False 14286.427864311596 14728.351591418239 11583.836349066452 10779.728850948706 10548.662796234945 13155.641506537135 12914.068160772425 12967.430703338414 13555.120456641751 15729.662011423474 0.9082476059521338 0.9363425342974283 0.7364326290452925 0.6853121728311811 0.6706223432248009 0.8363588166727939 0.8210009948970132 0.8243934735483176 0.86175535410726 1.0 13.941200050958996 -8.761379574025948 0.9793070049531822 0.9996429195998151 0.792380442584711 0.35715998438275354 0.08119121966276556 1.1294531675151915 2.10525245351181 0.08854806244057309 0.029008200370172977 1.7322893124850948e-09 8.761379574025948 -0.20726247701510414 KLGAGEGGEASVS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 KLGAGEGGEASVSPEK 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KLGAGEGGEAS(0.002)VS(0.998)PEK;KLGAGEGGEAS(0.007)VS(0.993)PEK 194.1 1.5809e-06 79416000.0 200866.0 179117.0 154658.0 145601.0 165253.0 115962.0 159691.0 159699.0 124546.0 165306.0 True False 189702.67185030735 192854.69794806925 144707.47265889842 125769.89262426517 144492.44075943573 131934.71290177264 167116.94792171358 160163.6976504074 149458.68010599614 160533.18626343168 1.1817037726953799 1.2013385047475396 0.9014178066673169 0.7834510455544024 0.9000783210166065 0.8218532004047466 1.0410118419220689 0.9976983661657476 0.9310142256862547 1.0 17.292512044111973 -5.260720428543097 24.9999996620371 0.9169166808514985 1.191521164896387 0.6720195097855537 0.0752286649633571 36.840627132619794 1280990.9252300537 0.021111537810044743 0.049563946082689124 5.48630024753961e-06 5.260720428543097 0.2746044840448886 KLGAGEGGEASVS(ph)PEKTSTTSK ddPTM_A459_Selumetinib_30min_R1 1 KLGAGEGGEASVSPEKTSTTSK 22 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KLGAGEGGEAS(0.12)VS(0.874)PEKT(0.001)S(0.001)T(0.002)T(0.002)S(0.001)K 66.372 0.0025031 195970000.0 4783.2 4579.0 9643.1 10109.0 5821.9 5315.2 4238.9 4787.5 3526.7 3170.3 True False 4894.639253512976 4042.8885512806505 8333.61998575672 8343.652919431908 5295.310172939926 5261.733913815467 3919.156360242033 4660.519948008348 5984.552320023242 3577.2388863370725 1.3682729638793738 1.1301701339326493 2.3296235589929983 2.332428217556201 1.4802786006729562 1.4708925182246466 1.095581392456311 1.3028260331756891 1.672952942248469 1.0 11.804630748711222 -6.5082627400685205 22.564835442789235 1.3320184259119638 1.7971241147563783 0.25511842402586316 0.38747391169192524 301.12920024200866 464897.97280192404 0.13364488444123476 0.14587863653010927 3.1026819554543295e-07 6.5082627400685205 0.4651056888444145 KLGAGEGGEASVS(ph)PEKTSTTSK ddPTM_A459_Selumetinib_30min_R2 3 KLGAGEGGEASVSPEKTSTTSK 22 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KLGAGEGGEAS(0.023)VS(0.971)PEKT(0.002)S(0.002)T(0.002)T(0.001)SK;KLGAGEGGEAS(0.071)VS(0.862)PEKT(0.011)S(0.011)T(0.015)T(0.021)S(0.008)K;KLGAGEGGEAS(0.009)VS(0.981)PEKT(0.002)S(0.003)T(0.004)T(0.001)S(0.001)K 76.439 0.0019171 161608000.0 177579.0 237046.0 200271.0 193717.0 157673.0 106665.0 90185.0 83624.0 53744.0 197202.0 True False 167709.8700850602 255226.66597697686 187385.78189857805 167332.41041953609 137864.70812549538 121357.13554153584 94378.78119818728 83867.33199530159 64494.30173282698 191508.2658676707 0.8757317566696842 1.3327187984320978 0.9784735977300257 0.8737607729953559 0.7198890737215374 0.6336913709269958 0.49281831659110514 0.43793061158651314 0.3367703291584895 1.0 17.547047137443116 -6.211616908112877 1.1880286864026808 0.5278806034183359 1.110139105337492 0.5320401362790447 0.19717589434935018 0.3236297680785796 0.9375960920597036 0.07706971173409038 0.11885800076025013 6.143036445089984e-07 6.211616908112877 0.5822585019191562 KLGDVS(ph)PTQIDVSQFGSFK ddPTM_A459_Selumetinib_30min_R1 4 KLGDVSPTQIDVSQFGSFK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KLGDVS(0.725)PT(0.275)QIDVSQFGSFK;KLGDVS(0.998)PT(0.002)QIDVSQFGSFK;KLGDVS(0.894)PT(0.106)QIDVSQFGSFK;KLGDVS(0.995)PT(0.005)QIDVSQFGSFK 176.9 4.2063e-13 5053623500.0 28278.9 32888.9 30206.5 31322.9 29495.2 27730.2 29239.299999999996 27932.199999999997 15799.259999999998 23960.9 True False 28937.743348839296 29038.25229836519 26104.623212427585 25852.94351865405 26827.364367800492 27451.25936500708 27033.756060304506 27191.347319427405 26810.190287705354 27036.514913930518 1.0703207658591076 1.0740382919472835 0.9655321070607819 0.956223226290655 0.9922641454789626 1.0153401594989917 0.9998979582377835 1.0057267886038488 0.9916289275098638 1.0 14.722621575532262 -5.25095014337427 24.86475907363588 0.991046150664073 1.0721795443851518 0.7887161450882333 0.016842156705123536 316.69728223162093 750728.4466786009 0.004898148850407517 0.012667190474906772 5.611123875453097e-06 5.25095014337427 0.08113339372107886 KLGDVS(ph)PTQIDVSQFGSFK ddPTM_A459_Selumetinib_30min_R2 7 KLGDVSPTQIDVSQFGSFK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KLGDVS(0.976)PT(0.024)QIDVSQFGSFK;KLGDVS(0.908)PT(0.092)QIDVSQFGSFK;KLGDVS(0.824)PT(0.173)QIDVS(0.003)QFGSFK;KLGDVS(0.98)PT(0.02)QIDVSQFGSFK;KLGDVS(0.891)PT(0.109)QIDVSQFGSFK;KLGDVS(0.963)PT(0.037)QIDVSQFGSFK;KLGDVS(0.918)PT(0.082)QIDVSQFGSFK 90.762 0.0013457 734789000.0 937944.0 961915.0 952886.0 1064370.0 1046930.0 718688.0 727636.0 762195.0 598722.0 929110.0 True False 885816.8273673236 1035690.7874557825 891578.3521838337 919400.9698593372 915405.2937270482 817680.7483998998 761472.5157833818 764412.8612618244 718483.1296904158 902284.1801823096 0.9817492612896541 1.1478543126473941 0.9881347493022512 1.01897050846394 1.014542107501084 0.9062341625392175 0.8439386753179289 0.8471974551381053 0.7962936128895043 1.0 19.783222365532993 -6.807121967184664 2.3213261721137486 0.8587330184176636 1.0387639156585835 0.5766749236004451 0.06512455233462397 0.19381661115802587 2.1408593363809416 0.024538371665124528 0.02201123969689746 1.5591145798768212e-07 6.807121967184664 0.18003089724091992 KLGDVS(ph)PTQIDVSQFGSFKEDTK ddPTM_A459_Selumetinib_30min_R1 2 KLGDVSPTQIDVSQFGSFKEDTK 23 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KLGDVS(0.72)PT(0.28)QIDVSQFGSFKEDTK;KLGDVS(0.799)PT(0.201)QIDVSQFGSFKEDTK 86.641 9.7827e-05 1101859000.0 7737.8 6321.1 18974.8 18332.9 11365.1 9635.7 8253.5 7981.5 6378.299999999999 5667.7 True False 7918.075684862168 5581.022673400334 16398.12638111569 15131.403166154241 10337.128711671381 9538.773606515595 7630.9318500690315 7769.8046924341725 10823.50924739962 6395.204503073089 1.2381270498945411 0.8726886952119333 2.5641285393197193 2.366054620909018 1.6163875145359432 1.491550989797422 1.193227182399271 1.2149423351044595 1.692441460190772 1.0 12.642774778382304 -6.84314122834103 2.868573753619355 1.299657648382452 1.7715065364242495 0.16296880608191755 0.4853518072913738 0.5523679869336181 9.205099250392236 0.20314295627215712 0.1799919523334659 1.4350227020456283e-07 6.84314122834103 0.4718488880417975 KLGDVS(ph)PTQIDVSQFGSFKEDTK ddPTM_A459_Selumetinib_30min_R2 1 KLGDVSPTQIDVSQFGSFKEDTK 23 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KLGDVS(0.498)PT(0.498)QIDVS(0.004)QFGSFKEDTK 41.615 0.041018 6881200.0 36076.0 51055.0 46897.0 50189.0 39481.0 19865.0 15433.0 14316.0 11022.0 42081.0 True False 34071.04034367035 54970.75433230064 43879.698077592904 43353.171619145876 34521.04381538176 22601.22343348436 16150.665079909353 14357.657189858612 13226.7079804112 40866.01219043146 0.8337255953652333 1.3451460366659345 1.0737455338954527 1.060861319600369 0.8447372759181201 0.553056738890131 0.39521020560188 0.35133492162027924 0.3236603542028052 1.0 15.318613847919398 -6.59872385021296 1.942902691363569 0.46107781992466923 1.1038053084955617 0.5938998848359474 0.2143665467727254 0.20149833528381075 1.5506695842182563 0.07808370100776636 0.08027864689534263 2.5192783228155166e-07 6.59872385021296 0.6427274885708925 KLGDVSPT(ph)QIDVSQFGSFK ddPTM_A459_Selumetinib_30min_R2 1 KLGDVSPTQIDVSQFGSFK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KLGDVS(0.124)PT(0.876)QIDVSQFGSFK 101.2 0.0015016 33274000.0 134740.0 116770.0 139840.0 143480.0 142610.0 106330.0 102070.0 86397.0 91038.0 131800.0 True False 127251.69020695591 125725.88352527133 130842.8466462796 123937.7764831946 124694.0568504241 120975.99233236314 106816.45724786811 86648.40096620668 109248.14381425106 127994.59154247415 0.9941958380696757 0.9822749696697148 1.0222529332644519 0.9683047931135955 0.97421348314585 0.9451648766910441 0.8345388344977199 0.6769692369185223 0.8535371885459534 1.0 16.965723324351906 -7.189138732522341 3.0338040322160618 0.8121713729741303 0.986899216722027 0.44191980377148543 0.07569355710616252 0.2052987470721743 3.704060797403869 0.031165467170816294 0.022512286308779286 6.469359233016555e-08 7.189138732522341 0.17472784374789663 KLGDVSPT(ph)QIDVSQFGSFKEDTK ddPTM_A459_Selumetinib_30min_R2 1 KLGDVSPTQIDVSQFGSFKEDTK 23 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KLGDVS(0.055)PT(0.945)QIDVSQFGSFKEDTK 113.33 4.0262e-05 8896700.0 13037.0 19615.0 14538.0 15832.0 11999.0 8100.9 5242.8 5318.1 3128.5 16482.0 True False 12312.455731245997 21119.40742783423 13602.640907777577 13675.654288276653 10491.578347578981 9216.725442351537 5486.600588411111 5333.574790541154 3754.2874175935767 16006.121834621119 0.7692341629322257 1.319458120214549 0.8498398955301695 0.8544014864797741 0.6554728531983167 0.5758250210501229 0.34278138359184773 0.3332209291950204 0.2345532200981428 1.0 13.966336175366145 -6.319000501546575 1.195115424542097 0.42930695756355325 1.0292320514808149 0.4476670739435783 0.23742169262705307 0.3670800557579581 1.0819123898153975 0.09548466592874727 0.13185397337639462 4.797328946150768e-07 6.319000501546575 0.5999250939172616 KLGPGRPLPTFPTSECT(ph)SDVEPDTR ddPTM_A459_Selumetinib_30min_R1 1 KLGPGRPLPTFPTSECTSDVEPDTR 25 2 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 KLGPGRPLPTFPTS(0.003)ECT(0.552)S(0.444)DVEPDTR 84.035 0.00014809 108560000.0 1533.2 1648.6 2777.0 2974.9 2386.8 1882.3 1759.8 1494.1 1035.6 1115.0 True False 1568.9205769121295 1455.5811455866535 2399.8986529691106 2455.389560789197 2170.9143614237664 1863.3657709916572 1627.0568691768922 1454.4716144792212 1757.337562768613 1258.1211110197248 1.2470346162783146 1.1569483516629688 1.9075259384400274 1.9516321117917408 1.7255209712395732 1.4810702679342 1.2932434365226888 1.1560664563528003 1.3967952269271329 1.0 10.297055092298535 -7.2167838705640746 2.672466757967811 1.2117032259919853 1.608993330293638 0.34313826929934255 0.25343553901025295 0.3820182962145071 5.388647534741635 0.12748619779750286 0.0886277195214662 6.070383509617498e-08 7.2167838705640746 0.39729010430165257 KLGPGRPLPTFPTSECTS(ph)DVEPDTR ddPTM_A459_Selumetinib_30min_R1 1 KLGPGRPLPTFPTSECTSDVEPDTR 25 2 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 KLGPGRPLPTFPTSECT(0.059)S(0.94)DVEPDT(0.001)R 114.24 3.4757e-08 106960000.0 1573.6 1948.7 2986.1 2882.9 2192.4 1910.5 1731.1 1843.9 991.11 1366.0 True False 1610.2618183074144 1720.5452980739472 2580.6040214731943 2379.455633735309 1994.097807099659 1891.2821045952076 1600.5217332833938 1794.9937821686865 1681.8412821896495 1541.3394059667662 1.0447159217975215 1.1162663404396507 1.6742607186212666 1.5437583860660824 1.2937434801058054 1.2270380535745458 1.0383966873795114 1.1645675022775546 1.091155702422827 1.0 10.589968865780959 -6.9470352221077585 2.5255951145880924 1.0878702752091434 1.354960789471369 0.3237530094558091 0.17621835328707797 0.3914195385756979 5.05894390826439 0.07919124533345331 0.06539930230424765 1.1297042897927285e-07 6.9470352221077585 0.26709051426222574 KLGPGRPLPTFPTSECTS(ph)DVEPDTR ddPTM_A459_Selumetinib_30min_R2 1 KLGPGRPLPTFPTSECTSDVEPDTR 25 2 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 KLGPGRPLPTFPTSECT(0.238)S(0.759)DVEPDT(0.003)R 76.967 0.00010638 8711000.0 10733.0 10110.0 13899.0 13905.0 13630.0 10629.0 8307.4 8068.4 8385.9 12835.0 True False 10136.502827603224 10885.404491226305 13004.75347208699 12011.115012537066 11917.67754625398 12093.048269544683 8693.710560800815 8091.87770820448 10063.314321623142 12464.4202006651 0.8132350052722341 0.8733181580837159 1.043350052607586 0.9636320678515119 0.9561357331019742 0.9702054387495216 0.6974821468500332 0.6491980836599763 0.8073632114140508 1.0 13.605528155031914 -7.255165904228025 24.927046194573823 0.7592773655703293 0.9407302492613974 0.31046135889656623 0.10447803712736517 486.1485940623697 1931669.4485328635 0.040365634469651454 0.030467823859637783 5.5569193761861175e-08 7.255165904228025 0.18145288369106805 KLIS(ph)S(ph)DY(ph)Y(ph)IWNSK ddPTM_A459_Selumetinib_30min_R1 2 KLISSDYYIWNSK 13 1 H0YIY0;E7EQ45;Q9H0R1 H0YIY0 AP5M1 AP-5 complex subunit mu-1 4 KLIS(1)S(1)DY(0.886)Y(0.841)IWNS(0.273)K;KLIS(1)S(1)DY(0.759)Y(0.759)IWNS(0.482)K 66.98899999999999 0.031553 5876500.0 2542.3 2862.8999999999996 2693.0 3043.0 2903.0 2426.5 2754.6 2420.8 1695.55 2209.1000000000004 True False 2601.530643545336 2527.7103370738964 2327.305391590139 2511.5971741845183 2640.424162566276 2402.091613085722 2546.8183042588157 2356.592520133389 2877.2245119276968 2492.65950345621 1.0436766995003408 1.0140616211596836 0.9336635783440144 1.0075973756953367 1.0592799212668969 0.9636661604824444 1.0217273160363505 0.9454129281860773 1.1542789971667875 1.0 11.28347010923849 -8.250588779216955 24.973317886405564 1.0771395086605828 0.998908427636387 0.26942430402781103 0.0517072735702201 788.5221105773608 1814841.946453317 0.03378697355854337 0.012494859874502584 5.6157946759082575e-09 8.250588779216955 -0.07823108102419585 KLLLDPSS(ph)PPTK ddPTM_A459_Selumetinib_30min_R1 1 KLLLDPSSPPTK 12 1 F5GX19;F5H3Y3;Q6IAA8;H0YFI1;F5H479 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 KLLLDPS(0.08)S(0.833)PPT(0.086)K 78.902 0.022109 21033000.0 14616.0 10601.0 16612.0 11140.0 13301.0 12509.0 12930.0 16739.0 7608.2 10928.0 True False 14956.524362214766 9359.829991728804 14356.181643184316 9194.608123698825 12097.926898482283 12383.17081726326 11954.679689997278 16295.027344065114 12910.559719057714 12330.71524773413 1.2129486458592214 0.759066266934414 1.1642618740889652 0.7456670549089527 0.981121261453619 1.0042540573255692 0.9695041568812521 1.3214989574152611 1.047024398802019 1.0 13.589968865780959 -7.601681918756379 24.999991866282457 1.1396605659950523 0.9677383927043126 0.14594230550411225 0.15945956040212064 51.0038151356752 16177.673951083218 0.06927010739920854 0.039993117830844506 2.5021773082525998e-08 7.601681918756379 -0.17192217329073967 KLLLDPSS(ph)PPTK ddPTM_A459_Selumetinib_30min_R2 2 KLLLDPSSPPTK 12 1 F5GX19;F5H3Y3;Q6IAA8;H0YFI1;F5H479 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 KLLLDPS(0.074)S(0.925)PPT(0.001)K;KLLLDPS(0.1)S(0.899)PPT(0.001)K 80.411 0.020634 22490300.0 243460.0 93595.0 196063.0 241990.0 164328.0 138080.0 318030.0 231440.0 195873.0 167922.0 True False 229929.4678475989 100773.43554464157 183448.52003725362 209030.54454396616 143683.64752904078 157099.26663455943 332819.02516448987 232113.45208304515 235053.07314889127 163073.65554624717 1.4099731012799406 0.617962694262793 1.1249427102296619 1.2818167584689102 0.8810966250050889 0.9633638622273147 2.0409122739638557 1.423365725785294 1.4413920652084171 1.0 17.315164208769723 -7.193942534215693 24.99999831853885 1.5117060671720368 1.0337852965089274 0.311498282318066 0.31099506914011443 193.97397811344013 71845.27749020833 0.11403252738953858 0.08832920387151537 6.398194907060906e-08 7.193942534215693 -0.47792077066310945 KLNLTLS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 KLNLTLSPAK 10 1 A0A087WTW5;Q9UKL3 A0A087WTW5 CASP8AP2 CASP8-associated protein 2 1 KLNLT(0.013)LS(0.987)PAK 68.033 0.041627 16794000.0 115470.0 111070.0 121180.0 104450.0 105670.0 80824.0 102770.0 90009.0 73517.0 107490.0 True False 109052.63966303406 119588.7118536605 113383.41073080795 90223.7298136997 92394.78989821419 91956.77235277812 107549.00863489172 90270.91128820794 88222.45423660774 104386.48440743994 1.0447007606596008 1.1456340591650105 1.086188613156578 0.8643238665030583 0.885122153722316 0.8809260401361316 1.0302962998074334 0.8647758548497879 0.8451520782351384 1.0 16.67157540338839 -5.750610592256418 23.498416595079593 0.9072045575618752 1.0975206396432686 0.6484920928084212 0.0613705806899886 60.4339540521316 131138.48251287008 0.016683741129226746 0.028482408860989156 1.7757810114808166e-06 5.750610592256418 0.1903160820813934 KLNSSSSSSSNSSNEREDFDSTSSS(ph)SSTPPLQPR ddPTM_A459_Selumetinib_30min_R2 1 KLNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPR 34 2 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 KLNSSSSSS(0.001)SNS(0.004)S(0.004)NEREDFDS(0.012)T(0.012)S(0.049)S(0.049)S(0.217)S(0.217)S(0.217)T(0.217)PPLQPR 40.544 0.022832 3913200.0 8379.9 8314.9 7787.2 10595.0 9834.1 7135.9 5758.2 6608.9 4138.9 7736.3 True False 7914.178705397587 8952.62609338256 7286.180030062289 9151.942722605554 8598.652440030539 8118.805451749357 6025.967709656841 6628.130804837708 4966.795650528391 7512.932917678647 1.0534073433259028 1.1916286477570135 0.9698183265974881 1.2181584506192198 1.144513405649755 1.080643943012593 0.8020792646074565 0.8822294671686851 0.6610994274740625 1.0 12.875160505286976 -7.2147988044260245 4.889736709786681 0.8257649985445463 1.1161647812913718 0.6325801191281333 0.1020353950502146 0.1239582755253493 6.912736308507564 0.038357349174927495 0.028771711813358233 6.098193427747377e-08 7.2147988044260245 0.29039978274682543 KLNVTEQEK ddPTM_A459_Selumetinib_30min_R1 2 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 ; 99.343 0.025561 73002000.0 12185.1 12264.8 10939.8 11575.2 10442.3 10503.7 11276.5 10393.099999999999 6702.9 9663.1 False True 12468.989121922767 10828.83151424917 9454.235248019973 9553.808613414605 9497.7958087378 10398.042314596538 10425.904526237771 10117.441226453377 11374.331739553636 10903.453011564756 1.1435816808397783 0.9931561591326675 0.867086347599456 0.8762186257217187 0.8710814637036501 0.9536467304043816 0.9562020870984199 0.9279116639217232 1.0431862023424545 1.0 13.412497473612182 -10.180283254079328 15.914089335518351 0.9999999998987348 0.9512210576433755 0.013891953935194934 0.08180412034644463 0.0 0.0 0.08290370810651587 0.020107102663443534 6.602626732541884e-11 10.180283254079328 -0.04877894225535928 KLNVTEQEK ddPTM_A459_Selumetinib_30min_R2 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 119.34 0.0093756 36254000.0 155470.0 140140.0 157820.0 125400.0 139320.0 118940.0 135350.0 140240.0 103460.0 145460.0 False True 146829.59979572095 150888.28737887804 147666.03302142347 108320.3036729342 121817.3760633973 135322.90537018006 141644.04319093682 140648.07518201837 124154.89091393029 141260.19184953204 1.0394265919737766 1.0681585902106212 1.045347815885135 0.7668140773043487 0.8623616778968777 0.9579691461436193 1.0027173355520687 0.9956667433372475 0.8789092616140431 1.0 17.10799543541831 -5.567706776040938 24.999728516434217 0.9240072634950003 1.0545335986833935 0.4098186051855104 0.07015427985044384 128.98325452177326 71930.86645958242 0.02051570043726691 0.03553425342957244 2.705784620556149e-06 5.567706776040938 0.13052633518839318 KLPFTAGANGEQKDS(ph)DTEK ddPTM_A459_Selumetinib_30min_R2 1 KLPFTAGANGEQKDSDTEK 19 2 Q6UB99;A0A087WTN8;A0A2R8Y4T9;A0A2R8YE03;A0A2R8YEI0;X5D778 Q6UB99 ANKRD11 Ankyrin repeat domain-containing protein 11 1 KLPFTAGANGEQKDS(0.78)DT(0.22)EK 52.451 0.02829 7797200.0 26277.0 21200.0 17793.0 15817.0 17685.0 13206.0 16023.0 17635.0 9664.7 14818.0 True False 24816.62953516538 22825.971831255963 16648.217751553613 13662.697314153094 15463.252194094037 15025.006627867833 16768.10124897216 17686.314930368586 11597.91005428054 14390.165838212348 1.7245547976428521 1.5862202067638975 1.1569163231840682 0.9494468283244174 1.0745708123135151 1.0441162941965338 1.1652472554864746 1.2290556710196823 0.8059608335772536 1.0 13.812795597936757 -5.246226949892619 2.8365647397781957 1.0537259764833966 1.7044009460124045 0.8321501854407365 0.10988248070807398 0.1021005268640224 1.615392335252718 0.029487710556220032 0.09267180724787721 5.672481002863629e-06 5.246226949892619 0.6506749695290079 KLPPPPPQAPPEEENES(ph)EPEEPSGVEGAAFQSR ddPTM_A459_Selumetinib_30min_R1 2 KLPPPPPQAPPEEENESEPEEPSGVEGAAFQSR 33 1 R4GMQ1;O60341 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 KLPPPPPQAPPEEENES(0.999)EPEEPS(0.001)GVEGAAFQSR;KLPPPPPQAPPEEENES(0.999)EPEEPS(0.001)GVEGAAFQSR 79.04 4.8206e-06 16337000.0 3355.3 3733.5 4165.6 4428.7 3651.7 3200.5 3906.8 3155.8 1710.91 2848.8 True False 3433.471961722717 3296.3800843429376 3599.9344000029264 3655.3106819950617 3321.4043797599993 3168.3058758214947 3612.106930617276 3072.097932516918 2903.2893100776855 3214.4712296618773 1.0681296289230984 1.0254812841145498 1.119914954218332 1.1371421365558638 1.033266171154803 0.9856382743717266 1.123701745184767 0.9557086416480588 0.9031934345180236 1.0 11.65036572296657 -7.831306463544669 8.025584939500371 0.9456524862588451 1.068408569191306 0.533748798030151 0.0501883748957489 0.20572342343906858 20.667624897968874 0.028385658191859807 0.01360503150972775 1.4746655559106492e-08 7.831306463544669 0.12275608293246076 KLPS(ph)DSGDLEALEGK ddPTM_A459_Selumetinib_30min_R1 3 KLPSDSGDLEALEGK 15 1 G3V5V3;O60524-4;O60524-5;O60524-3;O60524;O60524-2 G3V5V3 NEMF Nuclear export mediator factor NEMF 1 KLPS(0.971)DS(0.029)GDLEALEGK;KLPS(0.999)DS(0.001)GDLEALEGK;KLPS(0.852)DS(0.148)GDLEALEGK 119.18 0.00099511 29399700.0 8912.3 18156.0 11118.4 13935.0 10480.0 12483.3 12421.3 11253.1 6387.2 10794.3 True False 9119.939249682999 16030.287079504596 9608.582348999551 11501.513842346783 9532.085850394275 12357.72933592953 11484.351340553998 10954.631232779677 10838.611897369345 12179.853550385846 0.748772488269704 1.3161313486398014 0.7888914517116801 0.9443064150785645 0.7826108754889182 1.0146040988758893 0.9428973257392068 0.8994058251572856 0.889880313628729 1.0 13.572209166044738 KLPS(ph)DSGDLEALEGK ddPTM_A459_Selumetinib_30min_R2 2 KLPSDSGDLEALEGK 15 1 G3V5V3;O60524-4;O60524-5;O60524-3;O60524;O60524-2 G3V5V3 NEMF Nuclear export mediator factor NEMF 1 KLPS(0.917)DS(0.083)GDLEALEGK;KLPS(0.757)DS(0.243)GDLEALEGK 103.73 0.0028028000000000003 5212300.0 59089.0 46461.0 55508.0 44460.0 42915.0 40164.0 48561.0 51116.0 36829.0 53969.0 True False 55805.06993200846 50024.409304338835 51936.6757125408 38404.47130222208 37523.63403503226 45696.226427508984 50819.182721796016 51264.73909729067 44195.829088238424 52410.774741698064 1.0647633088241661 0.9544680373621603 0.9909541686515068 0.732759084205398 0.7159526685107064 0.8718861083950553 0.9696323508334675 0.978133587033286 0.8432584579421639 1.0 15.677575814755857 -5.5673537758248 24.987155959283204 0.869006979588915 1.0003898763811025 0.2877938756993562 0.09386500635488083 175.62795713070778 98671.23993408159 0.027922740393739535 0.04836362008161082 2.70798481161786e-06 5.5673537758248 0.1313828967921875 KLPS(ph)PVTITPSSMR ddPTM_A459_Selumetinib_30min_R1 1 KLPSPVTITPSSMR 14 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 KLPS(0.994)PVT(0.006)ITPSSMR 145.7 0.00069617 0.0 1507.6 1790.8 2065.7 1801.0 1524.4 1461.8 1631.6 1586.3 683.46 1259.5 True False 1542.7241467210583 1581.1323034796667 1785.1892860778862 1486.489158957056 1386.5182891546795 1447.0956192082044 1508.527098391303 1544.2261709714132 1159.781702056622 1421.1690935689192 1.0855317313767945 1.112557478652339 1.2561413656940845 1.0459622051195199 0.9756180988096056 1.0182430970083771 1.0614691138568217 1.086588624787404 0.8160757979503435 1.0 10.47286250422511 -5.984259374349678 23.776355159430548 1.002812053216413 1.1481128469055972 0.4397389865649016 0.07947695939990698 132.7936380129786 200582.78692915363 0.02223161231424125 0.032959877648359316 1.03690895615328e-06 5.984259374349678 0.14530079368918414 KLPTS(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 KLPTSLK 7 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 KLPT(0.023)S(0.977)LK 80.916 0.022588 11852000.0 93902.0 89521.0 105100.0 77633.0 81604.0 68205.0 98852.0 98206.0 62120.0 83045.0 True False 88683.30275948934 96386.97284461606 98337.9804242278 67059.2514756053 71352.1759709838 77599.61964665484 103448.81387152201 98491.76320112139 74545.73577782093 80647.27507317728 1.0996441315471648 1.1951671368580894 1.2193589967546756 0.831512923589265 0.884743792102593 0.9622100632196553 1.282731670445842 1.221265853207718 0.9243428957789339 1.0 16.299338167675216 KLQLERPVSPET(ph)QADLQR ddPTM_A459_Selumetinib_30min_R1 1 KLQLERPVSPETQADLQR 18 2 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 KLQLERPVS(0.255)PET(0.745)QADLQR 102.24 0.007628 48478000.0 1342.5 1268.5 2778.1 3103.3 2127.5 1989.6 1503.2 1342.3 730.02 1170.4 True False 1373.777637949734 1119.9834302903485 2400.8492790109763 2561.3669111557087 1935.0680006406324 1969.5864304122629 1389.8124137667367 1306.6978435951128 1238.7906214487682 1320.6322406614238 1.0402423897069883 0.8480660972879304 1.8179544653616346 1.939500515202383 1.4652587912524953 1.4913965976067778 1.052384131611587 0.9894486923480438 0.9380284558465223 1.0 10.367013056741994 -7.325417191373665 4.4087687092774015 0.982856581233878 1.449597949285246 0.33686613617815486 0.3018771221222945 0.3007654970939341 11.762082502947418 0.14838351181505674 0.09901733083787859 4.726969592828678e-08 7.325417191373665 0.466741368051368 KLQVYEGGGQPPPQDLPGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KLQVYEGGGQPPPQDLPGSPK 21 1 A0A494BYR6;Q86Y91-6;Q86Y91 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 1 KLQVYEGGGQPPPQDLPGS(1)PK 111.49 5.2022e-05 6195400.0 79832.0 77148.0 68588.0 72628.0 61834.0 52242.0 70792.0 66728.0 47253.0 70307.0 True False 75395.25703281668 83065.00353008164 64175.12275296807 62735.94110971175 54065.86011702628 59437.861294341295 74083.96827168677 66922.16743258492 56704.92035913355 68277.05423047613 1.1042546853048512 1.2165873947884054 0.9399222546470506 0.9188436996408809 0.791859882157796 0.8705393336640265 1.0850492761683714 0.9801560449090604 0.8305121097890418 1.0 16.059113195109582 -5.274784555370613 20.304589251661042 0.924896098898409 1.1604209125807663 0.5526190329255188 0.08395038328609217 42.83026100810763 65167.75596110953 0.023263749558625767 0.04919845000329159 5.311478705042742e-06 5.274784555370613 0.23552481368235734 KLS(ph)DASDER ddPTM_A459_Selumetinib_30min_R1 1 KLSDASDER 9 1 Q658Y4;E7ER68 Q658Y4 FAM91A1 Protein FAM91A1 1 KLS(0.93)DAS(0.07)DER 108.68 0.02131 19515000.0 4462.8 4264.3 3320.8 2939.9 3808.7 3089.9 4537.0 5375.5 2616.3 3922.4 True False 4566.7745569028475 3765.0337735807116 2869.8535998486936 2426.5016537578263 3464.203757480598 3058.8184114047303 4194.770437240342 5232.924277915166 4439.670013008424 4425.878247411453 1.031834655545213 0.8506862509791707 0.6484257901868796 0.5482531416622238 0.7827155569646982 0.6911212284688875 0.9477826100828061 1.1823470925743895 1.0031161647081088 1.0 12.111748048889192 -7.453937628828343 4.219578696522257 1.0704714664444168 0.7508813420808107 0.5291688038859307 0.12964968072237493 0.18031514564327925 6.194276512912431 0.06281082122267471 0.039804422462205946 3.5161093348207125e-08 7.453937628828343 -0.3195901243636061 KLS(ph)FLSWGTNK ddPTM_A459_Selumetinib_30min_R1 1 KLSFLSWGTNK 11 1 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 KLS(0.967)FLS(0.033)WGTNK 71.98 0.031764999999999995 43972000.0 5680.8 4870.0 5057.7 6089.9 4819.4 4530.5 5154.8 4939.8 3074.5 4025.0 True False 5813.151587087415 4299.818135998425 4370.8921199574625 5026.413286581104 4383.486120934177 4484.927283364875 4765.96928584671 4808.780457268225 5217.201947404502 4541.647956820083 1.2799652554218663 0.9467528476181188 0.9624022296562638 1.1067377600311492 0.9651752321206671 0.9875109929271307 1.0493920557382193 1.0588184075445557 1.1487464455649752 1.0 12.14900016538021 -10.288691468036081 8.671306437062118 1.0000218716506373 1.0468615648678052 0.02104941772882496 0.09787883840859798 0.0 0.0 0.09183967717762627 0.022274393507410634 5.144089687884202e-11 10.288691468036081 0.046839693217167966 KLS(ph)FLSWGTNK ddPTM_A459_Selumetinib_30min_R2 1 KLSFLSWGTNK 11 1 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 KLS(0.979)FLS(0.021)WGTNK 79.337 0.023551 3364700.0 18371.0 15422.0 14979.0 20402.0 20191.0 13101.0 19592.0 19478.0 17500.0 13901.0 True False 17350.013364939794 16604.81781045421 14015.267447902082 17623.212404586935 17654.426070169782 14905.543830962928 20503.066820811513 19534.67775524352 21000.488990854294 13499.642010864478 1.2852202562835775 1.2300191217730585 1.0381954896746617 1.3054577588356653 1.3077699435260242 1.1041436372140079 1.5187859651619426 1.447051539553572 1.5556330289316675 1.0 13.720633529344191 -7.262809651232026 24.99163494599336 1.4176219267145027 1.2133573158364652 0.18828369139548995 0.16431763591830187 168.5384379927377 3073841.075871549 0.06300563353958198 0.045101542276827604 5.45997116044027e-08 7.262809651232026 -0.2042646108780375 KLS(ph)GDQITLPTTVDYSSVPK ddPTM_A459_Selumetinib_30min_R1 2 KLSGDQITLPTTVDYSSVPK 20 1 E9PJ38;E9PND3;E9PN10;O00559;O00559-2 E9PJ38 EBAG9 Receptor-binding cancer antigen expressed on SiSo cells 1 KLS(0.976)GDQIT(0.024)LPTTVDYSSVPK;KLS(0.96)GDQIT(0.04)LPTTVDYSSVPK 93.876 0.00061128 640190000.0 16342.5 17110.9 23185.0 18085.8 18482.1 19829.6 20035.9 20299.1 9591.8 16662.3 True False 16723.248453030566 15107.547873358402 20036.604346088883 14927.45454251278 16810.397318279785 19630.13222783625 18524.57593200437 19760.70192723055 16276.58404264579 18801.068509546167 0.8894839378165876 0.8035473018827417 1.0657162562816778 0.7939684138129397 0.8941192523044301 1.0440966276926829 0.9852937838399233 1.051041429756885 0.8657265428494886 1.0 14.198527035580982 -6.711704186458603 11.076184374688706 0.9921456141444434 0.8889946291680522 0.2627331031101404 0.0835735412178428 0.8071921617133484 176.6076212360781 0.02671534996117394 0.026683834932034342 1.94220833488158e-07 6.711704186458603 -0.10315098497639119 KLS(ph)GDQITLPTTVDYSSVPK ddPTM_A459_Selumetinib_30min_R2 2 KLSGDQITLPTTVDYSSVPK 20 1 E9PJ38;E9PND3;E9PN10;O00559;O00559-2 E9PJ38 EBAG9 Receptor-binding cancer antigen expressed on SiSo cells 1 KLS(1)GDQITLPTTVDYSSVPK;KLS(1)GDQITLPTTVDYSSVPK 118.15 0.00013339 225650000.0 510640.0 226342.0 434980.0 453860.0 355390.0 302380.0 525290.0 436950.0 341630.0 404060.0 True False 482260.67305388127 243701.70359576115 406993.86037041515 392043.4850478295 310742.73097308865 344030.1002676565 549717.0258423889 438221.45215903333 409965.54593974614 392393.737926041 1.229022347815292 0.6210642016965481 1.0372078375193796 0.9991073943226956 0.7919156218330322 0.876747172587397 1.4009322084186786 1.1167901263542335 1.0447810612538804 1.0 18.581942492713807 -7.209846206292187 24.99738672286834 1.1503590447797056 0.9142948628293608 0.2541847247311747 0.17927446025423543 431.7231523388312 209174.03454546886 0.06572932952749487 0.05091367472697488 6.168133910604215e-08 7.209846206292187 -0.23606418195034484 KLS(ph)GDQPAAR ddPTM_A459_Selumetinib_30min_R1 2 KLSGDQPAAR 10 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KLS(1)GDQPAAR;KLS(1)GDQPAAR 104.94 0.014485 1292430000.0 14129.9 17263.0 16909.8 19445.9 16219.7 15465.6 16659.4 16688.9 9617.3 12846.2 True False 14459.099178000717 15241.839934649035 14613.542038882622 16050.0386097518 14752.630998820627 15310.030105641279 15402.76804544011 16246.25615881284 16319.855680199482 14495.1349025844 0.997513943483392 1.0515141830057408 1.0081687502112942 1.1072707303255365 1.0177643118168094 1.056218531840748 1.0626163984644177 1.1208075170046348 1.125885049699658 1.0 13.823281139812082 -7.407613240005831 2.757424676267656 1.0920480607072895 1.0404477000671637 0.1471642804056934 0.043382461495511455 0.4286890633684033 6.30695185115749 0.020464843778024155 0.012411913794082222 3.91189113320345e-08 7.407613240005831 -0.05160036064012585 KLS(ph)GDQPAAR ddPTM_A459_Selumetinib_30min_R2 2 KLSGDQPAAR 10 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 KLS(1)GDQPAAR;KLS(1)GDQPAAR 88.22399999999998 0.016709 1224670000.0 745160.0 777420.0 800480.0 793970.0 807420.0 563110.0 669140.0 766760.0 533930.0 665780.0 True False 703746.9903118254 837045.614200706 748977.988296725 685829.9163253543 705984.6811736155 640673.2910963695 700256.3358757566 768991.1446560492 640730.9192506761 646557.2014958172 1.0884527906946193 1.2946195824038333 1.1584094749296059 1.0607412843576396 1.0919137232410563 0.9908996290106503 1.0830539575705072 1.1893628945389205 0.9909887598008932 1.0 19.30241848664363 -5.658967994417786 4.2063508691712235 1.0655993534273953 1.1988694461012468 0.37033584146903764 0.0730816462017933 0.21934374900173514 6.959443874770998 0.019643387209473145 0.03512978910574041 2.192966541329058e-06 5.658967994417786 0.13327009267385148 KLS(ph)LGQYDNDAGGQLPFSK ddPTM_A459_Selumetinib_30min_R2 2 KLSLGQYDNDAGGQLPFSK 19 1 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 KLS(0.811)LGQY(0.189)DNDAGGQLPFSK;KLS(0.686)LGQY(0.314)DNDAGGQLPFSK 79.462 0.0035429000000000007 127047000.0 991220.0 970530.0 1050250.0 1168060.0 1097500.0 900030.0 1002490.0 1080390.0 917770.0 1463370.0 True False 936131.9605680495 1044966.5302541902 982678.0584257402 1008968.2129841094 959622.2382255137 1024000.9628411245 1049107.77139625 1083533.756031808 1101349.6446363644 1421118.705808124 0.6587288991004554 0.735312627990472 0.6914820376436724 0.7099816566064804 0.6752583259255751 0.7205597665107243 0.7382266992254326 0.7624512657552085 0.7749877896442705 1.0 20.438595637013947 -9.502277692573964 0.4407119070576968 1.0394554152954028 0.6910735520330694 0.9493059172053494 0.020553694633544797 0.8062661782259777 0.20567326135548167 0.07575556247995364 0.012013500215240457 3.1457362532278955e-10 9.502277692573964 -0.34838186326233334 KLS(ph)NPDIFSSTGK ddPTM_A459_Selumetinib_30min_R1 2 KLSNPDIFSSTGK 13 1 Q6P0Q8;Q6P0Q8-2 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 KLS(1)NPDIFSSTGK;KLS(0.999)NPDIFS(0.001)STGK 168.5 0.00050004 36684000.0 3295.5 4248.6 3960.3 4636.3 4153.5 3147.0 3204.81 4192.5 1884.9099999999999 3441.01 True False 3372.2787380732584 3751.171936879446 3422.5130123707468 3826.657239129704 3777.816658359983 3115.3440372473815 2963.0686014926678 4081.3012808407284 3198.5546016204985 3882.697151775772 0.8685402456719883 0.9661252964743408 0.8814782298447981 0.9855667567014754 0.9729877223703062 0.8023659624914506 0.7631469789338302 1.0511510739317187 0.8237970865581475 1.0 11.922843466883894 -6.71883617690236 24.999876185257687 0.8834794258007163 0.9365146914516844 0.06394671578336297 0.08864246225757116 403.8182379354973 236962.28541182482 0.029057151770872234 0.02905693383371149 1.910573822857802e-07 6.71883617690236 0.053035265650968166 KLS(ph)PTEPK ddPTM_A459_Selumetinib_30min_R1 1 KLSPTEPK 8 1 O14828-2;O14828 O14828-2 SCAMP3 Secretory carrier-associated membrane protein 3 1 KLS(0.945)PT(0.055)EPK 108.7 0.022924 146040000.0 4338.9 3724.4 5947.0 5282.1 4198.3 4547.2 3940.5 4766.0 2704.1 4007.5 True False 4439.9879279702845 3288.345516573416 5139.430064532695 4359.680392297093 3818.564506270065 4501.459296527262 3643.2649124852505 4639.590197850187 4588.660200350144 4521.901661355651 0.9818851139365977 0.7272041196021013 1.1365638727738079 0.9641254319073527 0.8444598737968291 0.9954792548889131 0.8056930878485782 1.026026336994523 1.0147633770024265 1.0 12.14271390253278 KLS(ph)PTEPK ddPTM_A459_Selumetinib_30min_R2 1 KLSPTEPK 8 1 O14828-2;O14828 O14828-2 SCAMP3 Secretory carrier-associated membrane protein 3 1 KLS(0.971)PT(0.029)EPK 97.734 0.035968 46958000.0 129200.0 72930.0 93427.0 110820.0 83430.0 85441.0 125370.0 116320.0 82950.0 91987.0 True False 122019.58122857899 78523.49649308951 87416.00853562626 95726.12482483676 72948.77752633677 97209.72219382513 131199.95341594223 116658.47194218745 99542.31781664939 89331.09629907142 1.3659250393622155 0.8790163755541612 0.9785619135688916 1.07158793287788 0.8166112423171399 1.0881957819970873 1.4686929731243659 1.305911119142955 1.1143075809054424 1.0 16.446874846801926 -7.01255361216923 24.927522316346433 1.2521096532527003 1.0084540336786312 0.2100863948520043 0.17848650719322037 742.5527681058187 1474475.007642788 0.06410773045043286 0.052272728917289554 9.715080148308708e-08 7.01255361216923 -0.24365561957406912 KLS(ph)SERPSSDGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R2 1 KLSSERPSSDGEGVVENGITTCNGK 25 2 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 KLS(0.375)S(0.375)ERPS(0.125)S(0.125)DGEGVVENGITTCNGK 49.793 0.015354 6949000.0 34361.0 33416.0 35135.0 40115.0 43238.0 34135.0 26234.0 31556.0 23787.0 41970.0 True False 32451.353177981407 35978.89975062497 32874.45235209559 34651.267797765184 37806.055887375616 38836.78640332186 27453.932981684804 31647.822735622973 28545.06466431149 40758.217048844104 0.7961916768609416 0.8827397849005107 0.8065723854578645 0.8501664279435865 0.9275689327153183 0.9528578337168274 0.6735803224361944 0.7764771137485392 0.7003511618308392 1.0 15.314803322342405 -10.139468360233767 5.300002572939695 1.0000000046562563 0.8226317567809854 0.2888981849499537 0.08520439048167337 14589381.639352582 3488880.2650830294 1.3832151925864669 0.021990201724538944 7.253233183304278e-11 10.139468360233767 -0.17736824787527083 KLS(ph)SSDAPAQDTGSSAAAVETDASR ddPTM_A459_Selumetinib_30min_R1 2 KLSSSDAPAQDTGSSAAAVETDASR 25 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 KLS(0.893)S(0.053)S(0.053)DAPAQDTGSSAAAVETDASR;KLS(0.605)S(0.198)S(0.198)DAPAQDTGSSAAAVETDASR 165.0 1.2844e-14 162327000.0 4855.299999999999 6928.9 8293.7 8708.5 8069.6 6807.0 12153.599999999999 13367.0 8458.3 5556.4 True False 4968.4190432308 6117.661166841781 7167.4610940331 7187.723953790957 7339.706104803591 6738.527760261498 11236.844167080497 13012.46373786477 14353.117330210285 6269.618063919281 0.7924596032130429 0.9757629738321718 1.1432053788540602 1.146437291795371 1.1706783459494141 1.0747907913307706 1.7922693300484862 2.07547949575263 2.289312871036011 1.0 12.614161843467258 -7.287209155948272 4.256621174005889 1.8938064667013899 1.056910661628396 0.5379080632346467 0.33090218434532637 0.14911915581619856 6.49699050004399 0.13584789729829394 0.09321389032034114 5.161677233533584e-08 7.287209155948272 -0.8368958050729938 KLS(ph)SSDAPAQDTGSSAAAVETDASR ddPTM_A459_Selumetinib_30min_R2 2 KLSSSDAPAQDTGSSAAAVETDASR 25 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 KLS(0.333)S(0.333)S(0.333)DAPAQDTGSSAAAVETDASR;KLS(0.722)S(0.139)S(0.139)DAPAQDTGSSAAAVETDASR 169.88 1.7074e-16 114091000.0 115316.0 83391.0 109598.0 126055.0 126436.0 63264.0 104924.0 145586.0 134823.0 180241.0 True False 108907.19836652324 89786.82155567291 102546.5840012799 108886.0915429963 110551.97932781864 71978.04174658706 109803.17390296164 146009.63115694028 161791.36726936855 175036.97400764137 0.6221953903394651 0.5129591737100825 0.5858567001781186 0.6220748053965033 0.6315921533412273 0.41121621391515145 0.6273141690518947 0.8341645071547347 0.9243268068739889 1.0 17.417300176969768 -7.863395380224276 2.366879539217964 0.9558126583687895 0.5649269683359881 0.8652612049734578 0.06427444078986608 0.10677319713503391 1.1652579853200926 0.047623881784419744 0.018670529507314546 1.3696342879876791e-08 7.863395380224276 -0.3908856900328014 KLS(ph)SSSEPYEEDEFNDDQSIKK ddPTM_A459_Selumetinib_30min_R1 1 KLSSSSEPYEEDEFNDDQSIKK 22 2 D6RAY8;Q9H4L7;Q9H4L7-2 D6RAY8 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 1 KLS(0.729)S(0.052)S(0.052)S(0.16)EPY(0.005)EEDEFNDDQSIKK 92.38 0.0026595 0.0 287.95 149.33 532.76 199.26 290.53 381.8 321.95 289.59 145.2 295.88 True False 294.65867474683523 131.84637417836646 460.41411824120365 164.4629815734496 264.25161279723756 377.95943864666367 297.66505229656786 281.9091324791095 246.3937950115901 333.85908011526124 0.8825839771831502 0.394916244700752 1.379067234242216 0.49261197723503747 0.7915064424966592 1.13209273360538 0.8915889068938974 0.844395582656561 0.7380173542876992 1.0 8.383095468163818 -6.56675504202296 24.999653351683758 0.9154371329831991 0.7816015266297532 0.059825095650043125 0.2629424156521734 444.37448636618836 253190.97938449358 0.08426624079547836 0.08426628067070852 2.7117207103147776e-07 6.56675504202296 -0.13383560635344582 KLSDAS(ph)DER ddPTM_A459_Selumetinib_30min_R1 1 KLSDASDER 9 1 Q658Y4;E7ER68 Q658Y4 FAM91A1 Protein FAM91A1 1 KLS(0.043)DAS(0.957)DER 131.42 0.0085501 0.0 5370.5 4990.4 3508.1 3118.2 3845.8 4019.8 5060.4 5090.2 2522.3 4251.7 True False 5495.62220082611 4406.121648025983 3031.719288613949 2573.664905863346 3497.948069031137 3979.364461686376 4678.689953848586 4955.191360700177 4280.158878496788 4797.447110065084 1.1455305446299238 0.9184304791566962 0.6319442860043994 0.5364655090128614 0.7291269687356037 0.8294754210708516 0.9752457601945532 1.0328808733095032 0.8921742710861739 1.0 12.228051186034817 -7.173540335232624 3.5790100857056797 0.9789918961569863 0.7766100256442149 0.23042025190971238 0.157578585524092 0.389570920928516 9.444057178033024 0.07189664579722024 0.053507808919117585 6.705940021872487e-08 7.173540335232624 -0.20238187051277146 KLSDAS(ph)DER ddPTM_A459_Selumetinib_30min_R2 1 KLSDASDER 9 1 Q658Y4;E7ER68 Q658Y4 FAM91A1 Protein FAM91A1 1 KLS(0.013)DAS(0.987)DER 70.41199999999998 0.037703 33786000.0 344570.0 234490.0 282280.0 319230.0 302420.0 272430.0 371710.0 377820.0 307050.0 236610.0 True False 325420.1788229983 252474.62899581165 264118.41212322545 275750.32329753437 264427.29593089735 309954.75962668716 388995.2515293918 378919.3936485317 368468.57969381684 229778.4545133905 1.4162345182108196 1.0987741628364835 1.1494481181125438 1.2000704064334493 1.1507923860436953 1.3489287334754196 1.6929143872656818 1.6490640710896152 1.6035819392820578 1.0 17.809884002516853 -7.0113358238749415 4.785529932327642 1.5403558009087162 1.1968912122593582 0.29691206183296204 0.1984442449397349 0.19021583582706295 11.826323520160576 0.07102888977993144 0.05810521632718814 9.74236005673511e-08 7.0113358238749415 -0.3434645886493579 KLSDASDERGEPDLAS(ph)GSDVNGSTESFEMVIEEATIDSATK ddPTM_A459_Selumetinib_30min_R1 1 KLSDASDERGEPDLASGSDVNGSTESFEMVIEEATIDSATK 41 2 Q658Y4;E7ER68 Q658Y4 FAM91A1 Protein FAM91A1 1 KLS(0.026)DAS(0.026)DERGEPDLAS(0.189)GS(0.189)DVNGS(0.189)T(0.189)ES(0.189)FEMVIEEAT(0.002)IDSATK 48.931 0.017365000000000002 3114400.0 426.1 217.05 400.5 423.83 362.19 309.11 211.34 300.92 160.76 162.84 True False 436.0273009537295 191.63768509619254 346.1142997890273 349.816046774441 329.429978449838 306.00063404942426 195.39845364918986 292.93862407408295 272.7979785541544 183.74210019592113 2.373039714299558 1.042971016940878 1.8836962210618657 1.9038426490251175 1.792893289554067 1.6653811713436437 1.0634386645240246 1.5942923465102847 1.484678678774622 1.0 7.521538413856154 -7.076045667060774 6.793828602054248 1.3360534807113427 1.7643274009778516 0.324739817601011 0.3466500898053965 0.35540245571415524 26.81170263370804 0.12796404376004095 0.09934030267700443 8.393717200174082e-08 7.076045667060774 0.4282739202665089 KLSFLS(ph)WGTNK ddPTM_A459_Selumetinib_30min_R1 1 KLSFLSWGTNK 11 1 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 KLS(0.012)FLS(0.967)WGT(0.021)NK 88.10799999999998 0.015972 38985000.0 7167.2 6503.4 9290.6 7645.7 7215.0 6741.3 7637.9 7187.1 4229.7 5960.0 True False 7334.1818150564895 5741.978904651363 8028.987549612824 6310.522022564108 6562.404523911706 6673.488642610671 7061.767053691428 6996.474761009045 7177.491974934729 6725.024055316199 1.090580755508041 0.8538228053046548 1.1938972237974121 0.9383642304707559 0.9758187435365467 0.9923367690164931 1.0500731291970666 1.040364272820446 1.0672812343713254 1.0 12.715323712840393 -7.266050016124805 23.469805464133717 1.0427933508160363 1.0043802084625417 0.03083600728615954 0.08592060293141943 649.130405632394 3304260.5492373593 0.03334938566318002 0.023384475697778594 5.419384737135053e-08 7.266050016124805 -0.03841314235349458 KLSLGQY(ph)DNDAGGQLPFSK ddPTM_A459_Selumetinib_30min_R1 1 KLSLGQYDNDAGGQLPFSK 19 1 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 KLS(0.435)LGQY(0.564)DNDAGGQLPFS(0.002)K 80.459 0.010734 325940000.0 6993.4 6359.1 7299.2 8569.2 6787.5 6778.2 7633.0 8501.4 5092.0 5044.1 True False 7156.332613212424 5614.573615734615 6308.008731635622 7072.750083806101 6173.571823430458 6710.017462113184 7057.236664636448 8275.915255560969 8640.752095034548 5691.559368694706 1.2573588624190433 0.9864736976331063 1.1083093969521909 1.242673514521936 1.0846889970764366 1.1789418378064023 1.239947825802078 1.4540681594364104 1.5181695446350418 1.0 12.47460825973701 -7.446764073268699 2.940266194632107 1.362978876078481 1.1356182683164593 0.2149819420950122 0.14818706440450508 0.31820390171590535 5.366865821450098 0.0700302404383882 0.04183021667906608 3.574669762667638e-08 7.446764073268699 -0.2273606077620216 KLSSERPS(ph)SDGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R1 1 KLSSERPSSDGEGVVENGITTCNGK 25 2 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 KLS(0.011)S(0.011)ERPS(0.489)S(0.489)DGEGVVENGITTCNGK 85.881 0.00010561 23975000.0 2853.6 2716.9 3999.5 3807.4 3448.6 2928.6 2650.4 2789.4 1795.8 2414.6 True False 2920.083327860977 2398.804084947458 3456.3898676809363 3142.509063749634 3136.6747388997815 2899.140942956047 2450.478194150719 2715.41605075185 3047.341439957392 2724.5374301957227 1.0717721457954816 0.880444532845025 1.2686152993804307 1.1534101271362918 1.1512687269906408 1.0640855621307364 0.8994107282184352 0.9966521364901133 1.1184802991451215 1.0 11.411795595722174 -7.008029082241166 24.418006591088446 1.0002698461029165 1.1047178480967101 0.17603369534324598 0.10341357243802414 518.294921076941 1576238.6261012529 0.0394665389297697 0.033253868291471034 9.816822031230003e-08 7.008029082241166 0.10444800199379367 KLSSERPS(ph)SDGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R2 2 KLSSERPSSDGEGVVENGITTCNGK 25 2 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 KLS(0.01)S(0.013)ERPS(0.756)S(0.221)DGEGVVENGITTCNGK;KLS(0.119)S(0.119)ERPS(0.436)S(0.324)DGEGVVENGIT(0.001)T(0.001)CNGK 76.04899999999998 0.00033033 29183000.0 35927.0 36279.0 39695.0 46317.0 43270.0 30377.0 28671.0 28219.0 20402.1 43064.0 True False 33930.32116717611 39061.482644629 37141.06691664818 40008.54469871843 37834.03576129196 34561.15601504929 30004.25831050872 28301.11261809306 24483.090082303326 41820.630426290736 0.8113297389664803 0.9340242422570659 0.8881039462594824 0.9566700523377781 0.9046739701347835 0.8264140368702394 0.7174511241142458 0.6767261117207222 0.5854309184902176 1.0 15.351927189588563 -7.061374434894654 2.734444496505473 0.7174687633901149 0.9031391713986819 0.3069643538689161 0.10564860176624394 0.2814045907482497 4.151713192775166 0.04194986741082151 0.03237096900267555 8.682115621023933e-08 7.061374434894654 0.18567040800856704 KLSSERPSS(ph)DGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R1 1 KLSSERPSSDGEGVVENGITTCNGK 25 2 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 KLS(0.004)S(0.004)ERPS(0.222)S(0.769)DGEGVVENGITTCNGK 80.702 0.00021327 29357000.0 3604.2 3693.9 5962.9 5760.3 4598.5 3728.6 3930.3 3226.0 2258.1 2841.5 True False 3688.170847447622 3261.416470752479 5153.170931865142 4754.371739222832 4182.566486931116 3691.0936692979276 3633.8343066973184 3140.43600047518 3831.8307749013206 3206.234203553855 1.1503123643804867 1.017210928364952 1.6072347198321517 1.4828522925595984 1.3045105944834205 1.1512239702285767 1.133365211645956 0.9794780421824012 1.1951188003215865 1.0 11.646664097542198 -6.897797960136271 2.6366098201589505 1.0780320051292522 1.3232361585238444 0.3241265236637936 0.16195385804165568 0.37345372489586354 5.265250757653022 0.06972153593664322 0.0595916452157451 1.265324857379907e-07 6.897797960136271 0.24520415339459212 KLSSS(ph)DAPAQDTGSSAAAVETDASR ddPTM_A459_Selumetinib_30min_R2 2 KLSSSDAPAQDTGSSAAAVETDASR 25 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YIM6 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 KLS(0.31)S(0.103)S(0.587)DAPAQDTGSSAAAVETDASR;KLS(0.307)S(0.1)S(0.593)DAPAQDTGSSAAAVETDASR 167.87 2.3268e-16 135096000.0 68360.0 51028.0 61782.0 70226.0 65198.0 35751.0 70846.0 88259.0 63872.0 93308.0 True False 64560.82486676201 54941.683519119266 57807.01338315552 60661.09765339293 57007.24436248475 40675.37573473441 74140.47937868575 88515.81907793599 76648.18473279102 90613.95559670126 0.7124821385582719 0.6063269521490725 0.6379482387949076 0.6694454210053408 0.6291221256934076 0.448886437711314 0.8182015550525727 0.9768453269151661 0.8458761592301721 1.0 16.467445638647284 -7.484007435170301 6.150564690894353 0.9279328399311121 0.6207537005577928 0.7963239358098071 0.0744008808201378 0.08563133760390124 9.230144190327875 0.03200762312917963 0.02074392829169014 3.2808967613293814e-08 7.484007435170301 -0.3071791393733193 KLSSWDQAET(ph)PGHTPSLR ddPTM_A459_Selumetinib_30min_R1 1 KLSSWDQAETPGHTPSLR 18 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 KLSSWDQAET(0.948)PGHT(0.015)PS(0.037)LR 135.33 0.00045002 14043000.0 2582.4 3067.6 4750.1 5325.3 3646.4 3687.7 3261.4 3031.3 1809.8 2674.7 True False 2642.564895524316 2708.4439659114496 4105.062510431607 4395.336323261524 3316.5837638242083 3650.605086163702 3015.389972231796 2950.9000769499116 3071.0984174378514 3018.023798784268 0.8755944524323513 0.8974229981229689 1.3601822861984136 1.456362380254281 1.0989256496785107 1.2096011594190386 0.9991273009333018 0.9777590482018745 1.0175858847352242 1.0 11.559388467018621 -7.27430574103043 22.60395549270718 0.9967645785412419 1.1594163586539168 0.15990977218223124 0.16872099120953088 450.3882008724315 791245.678060205 0.07847232448959564 0.05339802731991716 5.317337896794757e-08 7.27430574103043 0.1626517801126749 KLSSWDQAETPGHT(ph)PSLR ddPTM_A459_Selumetinib_30min_R1 1 KLSSWDQAETPGHTPSLR 18 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 KLSSWDQAET(0.003)PGHT(0.868)PS(0.129)LR 69.581 0.031624 14366000.0 1099.7 1296.1 1678.0 2156.5 1445.7 1331.4 1291.2 1181.8 697.58 1245.0 True False 1125.3208703562925 1144.3520094594564 1450.136816594227 1779.90775751854 1314.936690259066 1318.0073248144786 1193.8037444489157 1150.4548249725872 1183.7423107726245 1404.8078773269579 0.8010496584753867 0.8145968056763093 1.0322670024840124 1.2670115154147021 0.9360259943595297 0.938211798272628 0.8497985836472267 0.818941040650805 0.8426364415218309 1.0 10.456157124446312 -7.019921732256242 2.7555008647468098 0.8635470067209551 0.9806825032862856 0.09512110950269304 0.12951831497699823 0.6254036702924821 9.541444757764085 0.05857522297277982 0.04646046705735501 9.551647085183716e-08 7.019921732256242 0.11713549656533051 KLSVPT(ph)SDEEDEVPAPKPR ddPTM_A459_Selumetinib_30min_R2 1 KLSVPTSDEEDEVPAPKPR 19 2 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KLS(0.001)VPT(0.911)S(0.088)DEEDEVPAPKPR 117.2 0.00059627 35600000.0 84512.0 75848.0 87027.0 89059.0 76347.0 45270.0 46500.0 60873.0 55305.0 71447.0 True False 79815.16136834103 81665.29771024053 81427.77756783323 76929.01056465587 66755.60730916008 51505.53157985587 48662.342138001964 61050.13035193233 66367.5453508111 69384.13946840048 1.150337266987236 1.1770023860774874 1.173579123293988 1.1087405731924014 0.9621162389649943 0.7423242829625777 0.7013467704699888 0.8798859626952108 0.956523289894469 1.0 16.082318294148735 -6.35000373761841 2.62735339436497 0.8396638306945665 1.1628318681568233 0.7255538562058688 0.08560750758649646 0.14794264442414648 1.9961883634871955 0.030019733494411914 0.03568201195879427 4.4667974792612746e-07 6.35000373761841 0.32316803746225675 KLSVPTS(ph)DEEDEVPAPK ddPTM_A459_Selumetinib_30min_R2 1 KLSVPTSDEEDEVPAPK 17 1 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KLS(0.057)VPT(0.014)S(0.928)DEEDEVPAPK 110.38 0.0010975 5165500.0 59181.0 47700.0 50614.0 55431.0 56207.0 42857.0 49030.0 52787.0 44499.0 47777.0 True False 55891.95694031367 51358.436620325905 47357.55034435648 47881.20217619148 49145.77416304455 48760.16273288893 51309.99215110189 52940.60143064174 53400.04340594426 46397.55387044617 1.2046315436451305 1.1069212132116228 1.0206906699562408 1.0319768647693806 1.0592320082276776 1.0509209789171163 1.1058770963308218 1.1410213904479842 1.1509236791890114 1.0 15.50176112645398 -7.419736876473211 7.350211669978417 1.1121764612469205 1.074733315369103 0.007138150098226936 0.06195539447231289 0.8125561117510819 50.78955699270634 0.026932001561190595 0.01804675265758385 3.804198092994368e-08 7.419736876473211 -0.037443145877817496 KLSVPTS(ph)DEEDEVPAPKPR ddPTM_A459_Selumetinib_30min_R1 2 KLSVPTSDEEDEVPAPKPR 19 2 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KLS(0.08)VPT(0.127)S(0.792)DEEDEVPAPKPR;KLS(0.012)VPT(0.161)S(0.827)DEEDEVPAPKPR 119.04 0.00017488 147205000.0 5557.4 9101.6 10518.0 12238.5 9011.8 8370.2 8251.5 6704.0 4062.0 5496.1 True False 5686.876607182017 8035.980440780959 9089.713371238426 10101.275720097683 8196.684281162512 8286.003387533528 7629.082711679241 6526.188142338999 6892.91732325812 6201.577971547546 0.9170047741515229 1.2957960824889305 1.4657097617640968 1.6288234650022473 1.3217094614900256 1.3361121033306678 1.2301841155075366 1.0523431572223623 1.1114779746191041 1.0 12.598419635979932 -7.575627087408115 2.182702225560468 1.0528845361137598 1.3472502858586224 0.33570100864199104 0.1699412143181974 0.3904155901430193 3.706569332747224 0.10893658927711776 0.05447836063414962 2.656885952388302e-08 7.575627087408115 0.2943657497448626 KLSVPTS(ph)DEEDEVPAPKPR ddPTM_A459_Selumetinib_30min_R2 2 KLSVPTSDEEDEVPAPKPR 19 2 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 KLS(0.006)VPT(0.178)S(0.816)DEEDEVPAPKPR;KLS(0.003)VPT(0.12)S(0.877)DEEDEVPAPKPR 101.05 0.00047597 89793000.0 179146.0 158367.0 182698.0 166260.0 171465.0 111951.0 122119.0 121510.0 97965.0 175082.0 True False 169189.78249825822 170513.23966983578 170943.40958654173 143615.10118550228 149924.03378345122 127371.23406000531 127797.77547420771 121863.57398293649 117560.7373708021 170026.927742333 0.9950763961027195 1.0028602053448836 1.005390215869792 0.8446609198464347 0.8817664106161661 0.7491238932049035 0.7516325629777808 0.7167310237329844 0.6914242286901714 1.0 17.375403723410834 -6.0759887241244765 1.2038500197932551 0.7641406620154858 1.0122113237595773 0.5207561273769095 0.085610962963906 0.3335889233234917 0.9862528214475627 0.03166682759276795 0.056177137750995094 8.394817822584451e-07 6.0759887241244765 0.24807066174409154 KLT(ph)ATPTPLGGMTGFHMQTEDR ddPTM_A459_Selumetinib_30min_R1 2 KLTATPTPLGGMTGFHMQTEDR 22 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 KLT(0.454)AT(0.454)PT(0.092)PLGGMTGFHMQTEDR;KLT(0.5)AT(0.5)PTPLGGMTGFHMQTEDR 99.954 7.9026e-05 60923000.0 5373.4 7511.6 7889.2 8798.5 7357.6 6352.5 6617.700000000001 5848.5 2791.3 4936.4 True False 5498.589765183689 6632.138379951901 6817.889972273643 7262.007143300191 6692.106379089789 6288.5996176085155 6118.521561059163 5693.378781394632 4736.632231514129 5570.035024607869 0.9871732836313343 1.190681629586127 1.2240300001980011 1.3037632817778264 1.2014478094885792 1.1290053993962512 1.0984709313367214 1.0221441617946463 0.8503774591341261 1.0 12.443470683981293 -7.690754387405755 1.5816315404219075 0.9273777597987403 1.1854913935484104 0.5762493762928202 0.08421315200629133 0.2865911120592154 1.3678800844694878 0.06546755984396499 0.027195063272152337 2.0381944402481494e-08 7.690754387405755 0.2581136337496701 KLTS(ph)DEEGEPSGK ddPTM_A459_Selumetinib_30min_R1 3 KLTSDEEGEPSGK 13 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 KLT(0.2)S(0.8)DEEGEPSGK;KLT(0.033)S(0.964)DEEGEPS(0.003)GK;KLT(0.036)S(0.946)DEEGEPS(0.018)GK 144.88 0.0011600999999999998 181763000.0 24056.3 28391.8 28738.2 30338.4 23777.8 24193.300000000003 25213.100000000002 23773.199999999997 14199.300000000001 21187.0 True False 24616.764984588594 25067.67485701026 24835.710287633014 25040.36796230024 21627.102188311557 23949.937367758852 23311.255567816726 23142.657509763354 24095.175024160286 23906.557828856432 1.0297076292127219 1.0485689757792023 1.03886600762135 1.0474267412967015 0.9046514493277047 1.0018145455825538 0.9750987881525485 0.9680464111746354 1.0078897680148742 1.0 14.545118798986902 -6.166018131005085 24.999999932454443 0.9758638555533219 1.041510765540348 0.5692695906331089 0.027650924484224175 36.35774849705061 9522.595260537872 0.007789454385927609 0.010056145847688379 6.823102083362797e-07 6.166018131005085 0.06564690998702605 KLTS(ph)DEEGEPSGK ddPTM_A459_Selumetinib_30min_R2 4 KLTSDEEGEPSGK 13 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 KLT(0.002)S(0.998)DEEGEPSGK;KLT(0.005)S(0.995)DEEGEPSGK;KLT(0.053)S(0.941)DEEGEPS(0.006)GK;KLT(0.088)S(0.912)DEEGEPSGK 197.17 0.0003145 105566800.0 157519.0 140532.0 146001.0 152540.0 143203.0 108859.0 129783.0 135352.0 99906.0 131879.0 True False 148764.72457851798 151310.3525183994 136607.4546138696 131763.78885382254 125212.55888893669 123853.33912638684 135818.16666013584 135745.8519112702 119889.99160687366 128071.31060720806 1.161577279667077 1.1814539243879918 1.0666514925644957 1.028831423908351 0.977678437858428 0.9670654461110526 1.0604886138526937 1.0599239694485505 0.9361190342978036 1.0 16.966587806632567 -5.458983638710971 2.179234659620431 1.005496948789121 1.176199209570501 0.7579528177213886 0.037429002444850874 0.15948789065401453 1.4625926501451705 0.011132045917736443 0.029926746961154473 3.4754925451007943e-06 5.458983638710971 0.17070226078137996 KLTS(ph)DEEGEPSGKR ddPTM_A459_Selumetinib_30min_R1 2 KLTSDEEGEPSGKR 14 2 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 KLT(0.12)S(0.88)DEEGEPSGKR;KLT(0.06)S(0.94)DEEGEPSGKR 92.427 0.017769999999999998 66117000.0 6567.1 6087.700000000001 9131.0 10201.2 7077.5 6488.6 6005.8 6289.9 4349.8 5523.2 True False 6720.100652647824 5374.949253905053 7891.06035299278 8419.75192024026 6437.341374634111 6423.330575177429 5552.777670702677 6123.07141952537 7381.292903177788 6232.156520523896 1.078294588801969 0.8624541498924384 1.2661845585883058 1.3510174034480873 1.0329235720307242 1.0306754257573527 0.8909881599436934 0.9824964118537005 1.1843882416735727 1.0 12.60551575178246 -6.49527993346905 24.645985951071136 1.0112626219225191 1.136651986248943 0.15408091173754945 0.1367811695934155 1258.2131749375487 1123596.32743067 0.04603591387064035 0.052061547333553185 3.1968338602278806e-07 6.49527993346905 0.1253893643264239 KLVIIEGDLER ddPTM_A459_Selumetinib_30min_R1 1 KLVIIEGDLER 11 1 J3KN67;A0A2R2Y2Q3;A0A494C0P6;P06753;P06753-7;P06753-2;A0A087WWU8;P06753-5;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 91.62 0.035396 15017000.0 4567.8 4930.0 5651.3 5748.5 6154.1 4988.5 4926.2 3883.4 2940.2 4002.2 False True 4674.220852608414 4352.793308105179 4883.884500368863 4744.632387709403 5597.462741594601 4938.3202191956 4554.612767893629 3780.399616939031 4989.304656288413 4515.921354729279 1.0350536436409274 0.9638771285391705 1.0814813006551223 1.0506454862728305 1.239495177597077 1.0935354784298812 1.008567778339149 0.8371269825104514 1.1048254086762128 1.0 12.140804646297797 -10.717605207431808 5.0687617415828345 0.9999962999371108 1.0446633672449037 0.01926076466461013 0.09815892239309304 4.388847333221501e-06 6.970879957856467e-07 0.10162923480199107 0.02464666823724033 1.9159968580652982e-11 10.717605207431808 0.04466706730779291 KLYDIDVAK ddPTM_A459_Selumetinib_30min_R2 1 KLYDIDVAK 9 1 H7BY10;K7EJV9;K7ERT8;A8MUS3;P62750;K7EMA7 H7BY10 RPL23A 60S ribosomal protein L23a 0 121.9 0.008274600000000002 4277900.0 44237.0 42995.0 46778.0 51118.0 44153.0 34452.0 39480.0 39022.0 33971.0 44288.0 False True 41778.48463474179 46292.578249285376 43768.35440803548 44155.64021653149 38606.1054071718 39197.45027588234 41315.898228135855 39135.54755956015 40766.14922904632 43009.29036595684 0.9713827937930994 1.0763390387377179 1.0176488390210563 1.026653540219348 0.8976224689754404 0.9113717046331067 0.9606272941633709 0.9099324175443064 0.9478451953560705 1.0 15.392360707205858 -6.247250871271035 24.44240004401491 0.9332064340451139 1.026432906178892 0.5637991842560324 0.036483664682642886 389.8439336405562 671579.285584921 0.010239211597685012 0.013152158701799758 5.659122939800918e-07 6.247250871271035 0.093226472133778 KLYESLLVGS(ph)LPDMNK ddPTM_A459_Selumetinib_30min_R1 1 KLYESLLVGSLPDMNK 16 1 P13807-2;P13807 P13807-2 GYS1 Glycogen [starch] synthase, muscle 1 KLYESLLVGS(1)LPDMNK 101.17 0.0028856 4348100.0 2746.6 2687.0 3250.8 3369.3 2787.2 2889.9 2476.9 2383.9 1536.8 2092.6 True False 2810.590436046735 2372.404790847589 2809.359215366216 2780.915004594117 2535.0982521201286 2860.830229819257 2290.06543883637 2320.671228001483 2607.837356568952 2361.2055936501147 1.1903200820822764 1.0047429996047748 1.189798644777609 1.1777521669746625 1.0736457083354605 1.2115972609554884 0.9698712577146782 0.9828331909099153 1.104451625721239 1.0 11.205307949280737 -7.270914046818597 24.984315309192187 1.0128584491181858 1.135886823961529 0.45731777947994223 0.06762467994280964 650.7653766995761 1716033.927331989 0.027363763024890683 0.018728620146812792 5.3590270994283106e-08 7.270914046818597 0.12302837484334317 KLYGDADYLEER ddPTM_A459_Selumetinib_30min_R2 1 KLYGDADYLEER 12 1 B4E1E0;P17812-2;P17812;A0A3B3IRI2 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 0 90.861 0.035692 0.0 40057.0 45140.0 50210.0 50222.0 59831.0 42756.0 49506.0 43508.0 43567.0 47263.0 False True 37830.79230087601 48602.09285202328 46979.543264514534 43381.67696221766 52314.49488407349 48645.250899675644 51808.12709427796 43634.601076862884 52281.61736368847 45898.394385978514 0.8242291001018748 1.0589061665928496 1.0235552657778002 0.9451676369635779 1.1397892145014779 1.059846461961124 1.1287568505905037 0.9506781590205866 1.1390729035972544 1.0 15.48615606582683 -4.759993001186493 24.993697807198302 1.0495347486541602 0.8242288243703892 0.49596992315606336 0.06813735726019277 30.379183350865496 524774.8615718919 0.016248641470053334 0.099416561954716 1.7378288342673396e-05 4.759993001186493 -0.22530592428377094 KMANS(ph)SPVLSK ddPTM_A459_Selumetinib_30min_R2 1 KMANSSPVLSK 11 1 Q9NXE8 Q9NXE8 CWC25 Pre-mRNA-splicing factor CWC25 homolog 1 KMANS(0.6)S(0.4)PVLSK 77.77600000000002 0.025073 41316000.0 355750.0 395880.0 360720.0 428200.0 417460.0 315040.0 271120.0 255340.0 248720.0 374170.0 True False 335978.8391800845 426242.72304517124 337511.66792224045 369878.4213137996 365014.94266024866 358433.90035161906 283727.617214088 256082.9971261873 298470.9498174445 363366.73988958815 0.924627386871386 1.1730372547985224 0.9288457937146257 1.0179204112797724 1.0045359208472446 0.9864246256014847 0.7808299056217992 0.7047507903557716 0.8214041546789265 1.0 18.471066845598394 -7.211502258921662 5.11177952960199 0.8019045465541244 1.0122642878726966 0.4521690824692429 0.09509465278902078 0.16045904069061234 9.665202760915232 0.03578827563712434 0.027005285951546172 6.144658356398327e-08 7.211502258921662 0.21035974131857227 KMANSSPVLS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KMANSSPVLSK 11 1 Q9NXE8 Q9NXE8 CWC25 Pre-mRNA-splicing factor CWC25 homolog 1 KMANS(0.018)S(0.091)PVLS(0.891)K 71.933 0.031833 52664000.0 5224.9 6139.5 8017.1 8561.2 7510.9 6349.2 6187.5 5560.6 3595.7 4596.5 True False 5346.630004114388 5420.684485823887 6928.421854778051 7066.147133627508 6831.540421157095 6285.33281261235 5720.7718934151735 5413.114824625633 6101.640280462635 5186.505548701492 1.0308732833522147 1.045151583262265 1.3358554791313526 1.3624100210201469 1.3171759592289374 1.2118627375586175 1.1030108499252336 1.0436920916783508 1.1764453393846765 1.0 12.340547122757847 -7.277067986186114 4.15377917278199 1.0817847296043581 1.2268555526579976 0.2600334558860723 0.11272681231041029 0.34355462979598383 14.35553282813213 0.053726591438273213 0.03721419310115337 5.2836253332766186e-08 7.277067986186114 0.1450708230536395 KMDMSVLEIS(ph)GIIMS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 KMDMSVLEISGIIMSR 16 1 H0Y825;Q5TCQ3;Q5TCQ5;Q9UMS5-2;Q9UMS5 H0Y825 PHTF1 Putative homeodomain transcription factor 1 2 KMDMS(0.006)VLEIS(0.995)GIIMS(0.999)R 42.425 0.048008 0.0 562.5 642.5 901.23 753.66 502.99 544.72 530.2 572.87 400.23 485.11 True False 575.6051555655313 567.2758013098536 778.8479161020348 622.0474289503464 457.4946433100971 539.2406113661877 490.2065871335314 557.675626655988 679.1610783573602 547.3785938715505 1.0515667985741592 1.0363499918723023 1.4228687873841146 1.1364116827270705 0.83579198827321 0.9851328082674851 0.8955530826778454 1.0188115372061002 1.2407519876758903 1.0 9.096395206649303 -6.022554305324305 24.427165035100348 0.9909011263303905 1.1773322410069114 0.2568680047784734 0.13872697566530648 770.2565375133591 834216.7382098302 0.04238891056900335 0.05519513587891652 9.49392277272246e-07 6.022554305324305 0.18643111467652085 KMEES(ph)DEEAVQAK ddPTM_A459_Selumetinib_30min_R1 3 KMEESDEEAVQAK 13 1 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 KMEES(1)DEEAVQAK;KMEES(1)DEEAVQAK;KMEES(1)DEEAVQAK 192.78 0.00031399 33686300.0 4747.799999999999 6214.099999999999 6333.0 7291.6 5195.299999999999 5698.700000000001 5115.2 5124.8 2882.14 4062.5 True False 4858.414502389386 5486.550283143284 5473.013384678926 6018.258940283875 4725.386032304715 5641.376252005607 4729.356345728851 4988.873656303536 4890.78107682303 4583.961447101016 1.0598724615063984 1.1969014893467487 1.1939483889290043 1.3128947548391654 1.0308520450784198 1.2306770720275844 1.0317181765827863 1.0883323766735853 1.0669332919272374 1.0 12.16237919518141 -7.272017911918372 24.94620164057204 1.0541069863428425 1.1731834237660157 0.3731659551310861 0.07853713960828827 814.0518632355028 1919683.285819587 0.032042691648182825 0.021875253508271464 5.3454231243087856e-08 7.272017911918372 0.1190764374231732 KMEES(ph)DEEAVQAK ddPTM_A459_Selumetinib_30min_R2 4 KMEESDEEAVQAK 13 1 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 KMEES(1)DEEAVQAK;KMEES(1)DEEAVQAK;KMEES(1)DEEAVQAK;KMEES(1)DEEAVQAK 159.4 0.00065419 49137300.0 221031.0 189892.0 190390.0 203096.0 199283.0 155259.0 181278.0 179239.0 137992.0 211845.0 True False 208746.98187719847 204456.10580098405 178140.51468095844 175433.97443985863 174247.28792737587 176644.51794912413 189707.78619554252 179760.55581538603 165594.2558186266 205728.48441058843 1.0146722388747385 0.9938152530834525 0.8659010695156315 0.85274518471507 0.8469769678544704 0.8586293650838396 0.9221269808070323 0.8737757259545248 0.8049165203984938 1.0 17.65038203238757 -5.230285937766911 5.252227988340429 0.8722997783853564 1.0073859780817283 0.505071181077859 0.049733511584150826 0.13656679794984908 10.706615054133179 0.01217164213945223 0.03220271426492358 5.884560906244942e-06 5.230285937766911 0.1350861996963718 KMLGEDS(ph)DEEEEMDTSER ddPTM_A459_Selumetinib_30min_R1 4 KMLGEDSDEEEEMDTSER 18 1 A0A087X0M4;Q9BWU0;A0A087WWF4;H7C256 A0A087X0M4 SLC4A1AP Kanadaptin 1 KMLGEDS(0.994)DEEEEMDT(0.002)S(0.004)ER;KMLGEDS(1)DEEEEMDTSER;KMLGEDS(0.996)DEEEEMDT(0.003)S(0.001)ER;KMLGEDS(1)DEEEEMDTSER 156.32 1.2228e-05 69547000.0 9118.0 10072.5 11608.1 12593.199999999999 9664.8 9527.6 9586.2 9485.3 5800.1 7991.4 True False 9330.431659460468 8893.20701742179 10031.783778729101 10394.034023641305 8790.62054645903 9431.760994368653 8863.105216106098 9233.719031403356 9842.346077456777 9017.174032827836 1.0347401109806897 0.9862521212350197 1.1125197032027425 1.15269307055635 0.9748753339412084 1.0459774825273944 0.9829138468259749 1.0240147298684896 1.0915111587760011 1.0 13.138459650778872 -6.300358397301168 24.99947546435659 1.0205391995824198 1.0683849420427194 0.19335222788339657 0.05152906349703696 1063.1260790620984 682892.2767992239 0.016951108112714143 0.019221196557619728 5.007738043454499e-07 6.300358397301168 0.0478457424602996 KMLGEDS(ph)DEEEEMDTSER ddPTM_A459_Selumetinib_30min_R2 4 KMLGEDSDEEEEMDTSER 18 1 A0A087X0M4;Q9BWU0;A0A087WWF4;H7C256 A0A087X0M4 SLC4A1AP Kanadaptin 1 KMLGEDS(1)DEEEEMDTSER;KMLGEDS(0.989)DEEEEMDT(0.005)S(0.007)ER;KMLGEDS(0.999)DEEEEMDTSER;KMLGEDS(1)DEEEEMDTSER 114.76 0.00055321 158071000.0 288206.0 328505.0 343071.0 320636.0 304677.0 218996.0 266167.0 235689.0 190723.4 312810.0 True False 272188.66430002946 353700.2771899412 320998.1853674615 276964.8236720486 266400.7514130611 249160.71115224462 278544.2928999047 236374.81596958556 228873.40925704534 303778.3625220144 0.8960107034624769 1.16433663758494 1.056685481818012 0.9117332168514053 0.8769576252941826 0.8202055902983817 0.916932630051026 0.77811603830887 0.7534223548935589 1.0 18.212659587878207 -5.91114086906569 2.8790164425536537 0.848862422734267 1.0525518126781628 0.44458506579919477 0.0897604950287105 0.21509679896477757 3.6003349434404592 0.02618034468508178 0.04151119811063828 1.2270411598372065e-06 5.91114086906569 0.20368938994389574 KMPLDLS(ph)PLATPIIR ddPTM_A459_Selumetinib_30min_R1 1 KMPLDLSPLATPIIR 15 1 B8ZZU6;E9PBF9;P15336-5;P15336;E9PEK8;H7C2N6;P15336-3;P15336-7;P15336-4;C9JCI8 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 KMPLDLS(0.691)PLAT(0.309)PIIR 110.64 0.0017715 42750000.0 5627.4 5275.9 7877.0 8704.4 7215.1 6190.2 5844.8 5505.2 3441.0 4435.7 True False 5758.5074709857245 4658.195175300631 6807.346665263837 7184.339941824426 6562.495478929371 6127.932208251904 5403.922030324523 5359.184212590193 5839.125679303596 5005.065302376855 1.150535931719226 0.9306961835420011 1.3600914781333817 1.4354138273505954 1.311170800471456 1.2243461050032276 1.0796906141780518 1.0707521058806508 1.166643255689522 1.0 12.289173177060148 -7.235175281736158 5.508214534042996 1.0846774187936816 1.2405484102956998 0.24936551976142618 0.1325149466981864 0.315305373663278 30.23684211813568 0.05905099730066415 0.04391271011501577 5.818683276685849e-08 7.235175281736158 0.15587099150201822 KMPLDLSPLAT(ph)PIIR ddPTM_A459_Selumetinib_30min_R1 1 KMPLDLSPLATPIIR 15 1 B8ZZU6;E9PBF9;P15336-5;P15336;E9PEK8;H7C2N6;P15336-3;P15336-7;P15336-4;C9JCI8 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 KMPLDLS(0.052)PLAT(0.948)PIIR 130.77 0.00095879 17201000.0 6828.3 7631.4 10910.0 10620.0 10518.0 7892.5 8263.3 7530.9 4735.1 6257.6 True False 6987.3861044411005 6737.912140258393 9428.481924340294 8765.41636208991 9566.648757103727 7813.108615816636 7639.992628179005 7331.156068189252 8035.1188619792065 7060.8239141856775 0.989599257730102 0.9542671255009586 1.3353231915892747 1.2414155158974565 1.354891280872148 1.1065434729394068 1.0820256560753112 1.0382862053053694 1.137986014045203 1.0 12.785620823336451 -6.986888827476478 24.989098857831095 1.0715534579452228 1.1809464817215545 0.1477034335201185 0.1250968885893167 505.3075826112217 963081.9385264234 0.04847836323075581 0.04273114608018205 1.0306499167660258e-07 6.986888827476478 0.10939302377633164 KMS(ph)DDEDDDEEEYGK ddPTM_A459_Selumetinib_30min_R2 2 KMSDDEDDDEEEYGK 15 1 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 KMS(1)DDEDDDEEEYGK;KMS(1)DDEDDDEEEYGK 81.639 0.013811000000000002 13829300.0 79047.0 59624.0 51443.0 65251.0 57655.0 52139.0 76279.0 75792.0 58444.0 52077.0 True False 74653.88419021256 64196.96907862288 48133.21338690343 56363.70123574659 50411.86345776031 59320.673979282175 79826.12464397112 76012.54217195886 70134.4330617993 50573.40169770439 1.476149155171447 1.269382064950891 0.951749571338174 1.1144929813630675 0.9968058656423855 1.1729619125457176 1.5784211060414899 1.5030142252703005 1.3867849641797543 1.0 15.626091200675427 -7.139052367459183 7.624719872963669 1.4082576840458871 1.1469623424280386 0.18984168537301316 0.19755055814226896 0.3688686962865143 21.40044360162455 0.07641326528499616 0.059151417599479374 7.260184084717944e-08 7.139052367459183 -0.2612953416178485 KMS(ph)DDEDDDEEEYGKEEHEK ddPTM_A459_Selumetinib_30min_R1 1 KMSDDEDDDEEEYGKEEHEK 20 2 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 KMS(1)DDEDDDEEEYGKEEHEK 76.61399999999998 0.0021966 17385000.0 3518.1 3872.9 2492.7 2915.6 2135.1 2875.6 3430.4 3646.3 2725.2 4478.8 True False 3600.0648849690597 3419.459067537639 2154.2050314209932 2406.4451925903318 1941.9805819825212 2846.674074835897 3171.642166169116 3549.5882791483727 4624.465359267116 5053.697607206406 0.712362544176661 0.6766251828486143 0.4262631441084183 0.4761751453349366 0.3842692485623439 0.5632853993433706 0.6275884337928053 0.7023744899352065 0.9150657041040169 1.0 12.30312362650008 -8.113559697812923 1.3528679756000006 1.002237877682 0.5332351354652232 0.7420316576607897 0.09623215762439197 0.2320978758332506 0.7767085783412161 0.0985397178260098 0.03205902770921574 7.699106057143894e-09 8.113559697812923 -0.46900274221677685 KMS(ph)DDEDDDEEEYGKEEHEK ddPTM_A459_Selumetinib_30min_R2 4 KMSDDEDDDEEEYGKEEHEK 20 2 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 KMS(1)DDEDDDEEEYGKEEHEK;KMS(1)DDEDDDEEEYGKEEHEK;KMS(1)DDEDDDEEEYGKEEHEK;KMS(1)DDEDDDEEEYGKEEHEK 67.994 0.0054167 114936000.0 298962.0 199577.0 205289.0 215986.0 200156.0 175942.0 295640.0 259441.0 164933.0 180271.0 True False 282346.88887970865 214883.9141588009 192080.9292417634 186568.3342033676 175010.61386265693 200176.41345754373 309387.84579954634 260195.93035723057 197924.2086130608 175066.1078296918 1.6128015432569163 1.2274444027044042 1.0971908362104217 1.0657021882548814 0.9996830113622628 1.143433277515256 1.7672629478946644 1.4862724349270102 1.1305683953721404 1.0 17.417540284657314 KMS(ph)GGSTMSSGGGNTNNSNSK ddPTM_A459_Selumetinib_30min_R1 4 KMSGGSTMSSGGGNTNNSNSK 21 1 A0A6E1WJ75;Q86U70-3;Q86U70-2;Q86U70 A0A6E1WJ75 LDB1 LIM domain-binding protein 1 1 KMS(0.925)GGS(0.054)T(0.021)MSSGGGNTNNSNSK;KMS(0.699)GGS(0.136)T(0.164)MS(0.001)SGGGNTNNSNSK;KMS(0.997)GGS(0.002)T(0.001)MSSGGGNTNNSNSK;KMS(0.956)GGS(0.022)T(0.022)MSSGGGNTNNSNSK 145.88 1.715e-06 53305000.0 11572.59 12400.900000000001 13609.6 13724.3 12497.150000000001 11969.220000000001 12828.02 11532.2 6947.629999999999 11540.6 True False 11842.208830659749 10948.996862978 11761.49107218163 11327.608642017934 11366.784989051033 11848.820513982235 11860.392123501848 11226.32859413511 11789.620675181637 13021.948424963446 0.9094037577324371 0.8408109528362484 0.903205164722855 0.8698858475205282 0.8728943333288421 0.9099114915297705 0.9108001150400149 0.8621082059128662 0.9053653332385035 1.0 13.668657709214552 -14.52287873190727 0.28436088499576617 1.8595768479779953 0.8790592463982642 0.6905500090990293 0.022867667670173362 128.68204513885158 1.2229366689661527 65.39671165681304 0.024550776450087634 3.0000000923778834e-15 14.52287873190727 -0.9805176015797311 KMS(ph)GGSTMSSGGGNTNNSNSK ddPTM_A459_Selumetinib_30min_R2 4 KMSGGSTMSSGGGNTNNSNSK 21 1 A0A6E1WJ75;Q86U70-3;Q86U70-2;Q86U70 A0A6E1WJ75 LDB1 LIM domain-binding protein 1 1 KMS(0.598)GGS(0.332)T(0.069)MSSGGGNTNNSNSK;KMS(0.716)GGS(0.201)T(0.083)MSSGGGNTNNSNSK;KMS(0.971)GGS(0.014)T(0.014)MSSGGGNTNNSNSK;KMS(0.995)GGS(0.004)TMSSGGGNTNNSNSK 109.22 6.0758e-05 83755900.0 207485.0 182651.0 185329.0 219864.0 198096.0 160748.0 177519.0 192671.0 153711.0 170087.0 True False 195953.8143282638 196659.74438446824 173405.13391095848 189918.14391344477 173209.4094792906 182889.57787494297 185773.98524722503 193231.64071159912 184457.4950441828 165176.14637090205 1.186332401097739 1.1906062025619 1.049819466798664 1.149791589682597 1.0486345231129797 1.1072396462396303 1.1247022607614943 1.169851972921675 1.1167320408964174 1.0 17.333645831913472 -11.437043363687938 2.126886618354981 0.9175063942630279 1.1256404790884522 0.3917282347698803 0.04747584661487886 4200473.409461099 1795341.4248884618 1726599.7963691493 0.012279013560084033 3.6555828931418865e-12 11.437043363687938 0.20813408482542428 KMSGGS(ph)TMSSGGGNTNNSNSK ddPTM_A459_Selumetinib_30min_R2 1 KMSGGSTMSSGGGNTNNSNSK 21 1 A0A6E1WJ75;Q86U70-3;Q86U70-2;Q86U70 A0A6E1WJ75 LDB1 LIM domain-binding protein 1 1 KMS(0.292)GGS(0.315)T(0.315)MS(0.036)S(0.041)GGGNT(0.001)NNSNSK 53.909 0.025877 3094700.0 12418.0 11047.0 11117.0 12859.0 13289.0 8853.9 11014.0 10391.0 8462.1 10992.0 True False 11727.857273192658 11894.269378296445 10401.744323274417 11107.58201698772 11619.517014832656 10073.444357298118 11526.17282382697 10421.236089677343 10154.756450829025 10674.632399354165 1.0986661492813763 1.1142556420974339 0.9744358338656929 1.0405587378971242 1.0885168294446992 0.9436806796183053 1.0797723418114449 0.9762618233399631 0.9512979998677432 1.0 13.381898768387233 -1.5228787452998789 0.3025795200460347 0.9866269583084132 2.072001652857497 0.3467019998028994 0.049982940704324734 62.7563916643579 0.8949515824048154 0.050182845340365184 36.976002059150666 0.029999999998650134 1.5228787452998789 1.0853746945490839 KMSQPGS(ph)PSPK ddPTM_A459_Selumetinib_30min_R2 1 KMSQPGSPSPK 11 1 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0;A0A2R8Y7M9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 KMSQPGS(0.769)PS(0.231)PK 97.073 0.010063 11242000.0 156230.0 139060.0 150280.0 143400.0 150630.0 108530.0 124850.0 138220.0 97520.0 137120.0 True False 147547.3620382422 149725.4548516253 140611.1484124924 123868.6726212023 131706.51275071432 123479.0223627515 130655.77238558172 138622.19731644716 117026.72493646356 133160.9893194544 1.1080374424395025 1.124394281064048 1.0559485111301252 0.9302174251953044 0.9890773072791552 0.9272912659617165 0.9811865551114023 1.0410120713649196 0.8788364034733581 1.0 17.022811968568995 -5.564378804945621 3.958681308748539 0.9661682424280577 1.112758088586694 0.6794721921119361 0.04279548500897759 0.11623131571890637 3.8881128732859658 0.011366301859953578 0.021689732360176472 2.726598522604658e-06 5.564378804945621 0.14658984615863624 KMT(ph)DT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 KMTDTR 6 1 O75897-2;O75897 O75897-2 SULT1C4 Sulfotransferase 1C4 2 KMT(1)DT(1)R 51.809 0.041897 0.0 6317.0 7441.5 7401.8 7889.6 7325.6 5788.8 5623.7 7873.9 5707.3 8597.8 True False 5965.926428954588 8012.23912180619 6925.576246470502 6815.022869680873 6405.292636305076 6586.1546545056235 5885.213193150145 7896.81174540568 6848.9194752858675 8349.559174232825 0.7145199290719141 0.9596002560868576 0.8294541187088286 0.8162134943258308 0.767141414611701 0.7888026801260167 0.7048531629444845 0.9457758883577534 0.8202731823761414 1.0 13.027484315310272 -8.8511902560725 1.0206452297947812 0.9981619110302379 0.8104438324014396 0.33423656078302044 0.07903015509063457 1.3281444248645367 2.4392027664685796 0.07534364234209627 0.024139529080828653 1.408671551274648e-09 8.8511902560725 -0.1877180786287983 KMT(ph)S(ph)NSPR ddPTM_A459_Selumetinib_30min_R1 2 KMTSNSPR 8 1 O60224-2 O60224-2 2 KMT(1)S(1)NSPR;KMT(0.998)S(0.999)NS(0.003)PR 91.318 0.015258 22291000.0 6689.6 6188.0 9000.400000000001 10076.7 8156.0 6821.200000000001 6773.5 6258.7 4341.0 5448.1 True False 6845.454664304318 5463.506083276846 7778.195115658328 8316.99350808582 7418.291240058752 6752.584921154063 6262.569441623867 6092.698944877248 7366.359945904359 6147.416703987954 1.1135498037514737 0.8887482899495911 1.2652786512117284 1.352924961584338 1.2067331038818885 1.0984426867912702 1.018731890675511 0.9910990645753347 1.1982854425869083 1.0 12.585764566446414 -6.969588237862082 5.454603363125639 1.0519099921013353 1.1655524306726224 0.15662323423013524 0.12451328770042827 0.39060828556804034 31.80947312781431 0.049699061008856044 0.04278633799959679 1.0725357130539603e-07 6.969588237862082 0.11364243857128709 KNDMDEPPPLDYGS(ph)GEDDGK ddPTM_A459_Selumetinib_30min_R1 2 KNDMDEPPPLDYGSGEDDGK 20 1 A0A5F9ZHX5;H7C2H0;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 KNDMDEPPPLDYGS(1)GEDDGK;KNDMDEPPPLDY(0.006)GS(0.994)GEDDGK 141.19 3.135e-05 26626000.0 9303.4 12398.8 9894.3 9197.5 8535.3 9668.3 11066.099999999999 9280.2 6060.1 10912.8 True False 9520.15111873487 10947.14273195426 8550.708405499558 7591.329283457808 7763.283622029609 9571.045680114024 10231.375167631777 9034.058949662045 10283.547087808112 12313.564179673593 0.7731434197135301 0.8890311994333103 0.694413760364728 0.6165013778861093 0.630466005516479 0.7772766309135145 0.830902817278611 0.7336672646393368 0.8351397643895423 1.0 13.587960792069202 -8.86889832093126 0.7826656333484994 1.0018085130882752 0.7327129114351664 0.503118318523927 0.07865219113169937 1.1485058960334809 1.3056267445578538 0.08944471750397068 0.031022792472091908 1.3523891538476638e-09 8.86889832093126 -0.26909560165310886 KNDMDEPPPLDYGS(ph)GEDDGK ddPTM_A459_Selumetinib_30min_R2 4 KNDMDEPPPLDYGSGEDDGK 20 1 A0A5F9ZHX5;H7C2H0;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 KNDMDEPPPLDYGS(1)GEDDGK;KNDMDEPPPLDYGS(1)GEDDGK;KNDMDEPPPLDYGS(1)GEDDGK;KNDMDEPPPLDYGS(1)GEDDGK 163.15 2.0533e-07 53197400.0 268227.0 221508.0 250822.0 243794.0 241936.0 216230.0 253644.0 263111.0 194773.0 228405.0 True False 253320.01713775558 238496.95133952127 234684.38559434548 210588.83663189213 211541.83674471796 246013.71975949238 265438.94858605106 263876.60944962926 233733.04241232356 221810.35418254125 1.1420567721977628 1.075229117317254 1.0580407143717439 0.9494094061027726 0.9537058697026709 1.1091173839298445 1.1966932272584767 1.1896496465285347 1.0537517208054696 1.0 17.758967187002014 -6.97666548808946 24.087786273417198 1.129696011447779 1.0340413480166668 0.17306436190039476 0.07630710609580377 220.28998100062438 227400.05829493635 0.02807121644289689 0.02475480520294157 1.055199342459219e-07 6.97666548808946 -0.09565466343111217 KNDMDEPPPLDYGS(ph)GEDDGKSDK ddPTM_A459_Selumetinib_30min_R1 1 KNDMDEPPPLDYGSGEDDGKSDK 23 2 A0A5F9ZHX5;H7C2H0;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 KNDMDEPPPLDY(0.408)GS(0.543)GEDDGKS(0.048)DK 44.844 0.031719 11515000.0 4951.7 5640.6 5316.1 5741.1 5143.2 5018.5 5167.7 5544.6 2445.5 3974.7 True False 5067.064975669053 4980.195929756205 4594.202819247058 4738.524658794197 4677.9984681057085 4968.018446433421 4777.896228460859 5397.539196600953 4149.834887746857 4484.891461856592 1.1298077152510309 1.1104384514345802 1.024373244775296 1.0565528060366058 1.0430572306802663 1.1077232277939744 1.0653315178519331 1.2034938286703944 0.9252921554603167 1.0 12.130857355796367 -8.287081174251362 24.98919412592444 0.9626460505873695 1.0876603627637043 0.504304672577008 0.05134856574612187 736.8807725389321 718119.2627075854 0.049083240806600655 0.012694854010918542 5.163198545878236e-09 8.287081174251362 0.12501431217633474 KNDMDEPPPLDYGS(ph)GEDDGKSDK ddPTM_A459_Selumetinib_30min_R2 3 KNDMDEPPPLDYGSGEDDGKSDK 23 2 A0A5F9ZHX5;H7C2H0;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 KNDMDEPPPLDY(0.001)GS(0.996)GEDDGKS(0.003)DK;KNDMDEPPPLDY(0.14)GS(0.837)GEDDGKS(0.023)DK;KNDMDEPPPLDY(0.187)GS(0.813)GEDDGKSDK 110.78 1.7299e-05 32036300.0 199283.0 182136.0 164491.0 175398.0 153595.0 120924.0 140785.0 145194.0 84522.0 177534.0 True False 188207.64865305644 196105.2455404549 153907.82814425958 151508.48982157363 134299.02294327796 137580.18336122125 147331.78146018522 145616.4905018392 101428.7617419991 172408.13213127194 1.0916402047077147 1.1374477706836934 0.8926947136523341 0.8787780944475098 0.7789599091591711 0.7979912644518844 0.8545523905334492 0.8446033763127048 0.5883061343346091 1.0 17.395468299378685 -5.418573078165429 1.9568696049176715 0.8094361293288151 1.1289011624207759 0.5762449909710783 0.09853716718472616 0.23852479122354833 1.7242846855939369 0.02734020515127047 0.08406735934875406 3.8144060436654827e-06 5.418573078165429 0.3194650330919607 KNGSTAVAESVAS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 2 KNGSTAVAESVASPQK 16 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 KNGSTAVAESVAS(1)PQK;KNGSTAVAESVAS(1)PQK 186.89 4.2883e-07 175771000.0 30092.0 29837.0 36419.0 35282.0 32280.0 26854.0 31435.0 30691.0 19166.3 28390.0 True False 30793.08505116082 26343.670169155022 31473.499835247392 29120.661025165344 29360.279699496885 26583.873141481145 29063.832641536308 29876.974981582054 32523.811248833612 32034.13304201795 0.9612585741206326 0.8223625135913943 0.9824988799904403 0.9090510109004318 0.9165311157628685 0.8298608583104806 0.9072770161569345 0.9326606386504535 1.0152861388873353 1.0 14.967322326102623 -8.122984797545106 3.0268496114151935 1.0085915428624481 0.9022345667423983 0.42882161285567566 0.046961094168422174 0.24725621966852843 4.05695001560274 0.03746345034299255 0.012124731984432422 7.533819353661225e-09 8.122984797545106 -0.1063569761200498 KNGSTAVAESVAS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 4 KNGSTAVAESVASPQK 16 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 KNGSTAVAESVAS(1)PQK;KNGSTAVAESVAS(1)PQK;KNGSTAVAESVAS(1)PQK;KNGSTAVAESVAS(1)PQK 167.63 7.4024e-06 207471500.0 323416.0 293017.0 316227.0 370371.0 345096.0 245398.0 316869.0 337093.0 230288.0 295461.0 True False 305441.83345682727 315490.46170184587 295881.2991019249 319925.83087438863 301741.9552826163 279199.34699875134 331604.03636401216 338073.88482124946 276352.03478433477 286930.2732301289 1.0645158840100897 1.0995370343819058 1.0311958224938393 1.1149950378982703 1.051621189656094 0.9730564288516984 1.1556955375637663 1.178244041715673 0.9631330694851079 1.0 18.130340665390655 KNPSVVIKPEACS(ph)PQFGK ddPTM_A459_Selumetinib_30min_R2 1 KNPSVVIKPEACSPQFGK 18 2 A0A0U1RRM7;A0A0U1RQW3;A0A0U1RQJ8;Q8WXE1-5;Q8WXE1-3;Q8WXE1-2;Q8WXE1 A0A0U1RRM7 ATRIP ATR-interacting protein 1 KNPS(0.003)VVIKPEACS(0.997)PQFGK 46.368 0.04613 7295100.0 51457.0 35266.0 44417.0 57869.0 57555.0 46146.0 43141.0 40631.0 36551.0 46694.0 True False 48597.22593869181 37970.7888019374 41559.258577573026 49987.142370406924 50324.426351771646 52502.19262831959 45147.14198226976 40749.22948317584 43862.221320269426 45345.82289441807 1.0717023716130196 0.8373602325036092 0.9164958517643054 1.1023538482650448 1.109791886872262 1.1578176175248647 0.9956185399345181 0.8986324843647715 0.9672825085211704 1.0 15.468682040180632 -4.42505495559618 22.57553154452038 1.0013479871053035 12.440757650469925 0.04904929902000443 0.09606375598072732 3000.414864347113 687057.8234092302 0.026034824949443897 13757.17640210168 3.757898488560499e-05 4.42505495559618 11.439409663364621 KNQKPSQVNGAPGS(ph)PTEPAGQK ddPTM_A459_Selumetinib_30min_R1 2 KNQKPSQVNGAPGSPTEPAGQK 22 2 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 KNQKPSQVNGAPGS(0.992)PT(0.008)EPAGQK;KNQKPSQVNGAPGS(0.98)PT(0.02)EPAGQK 134.0 2.1971e-05 128697000.0 10932.0 14271.0 15572.1 16491.9 13492.0 12674.7 13423.8 13317.0 6935.4 10739.7 True False 11186.694330030916 12600.144685592099 13457.4943514225 13611.899256304194 12271.650982206063 12547.204025706822 12411.231958436618 12963.789900287657 11768.867258425491 12118.245108536807 0.9231282442166769 1.0397664490806358 1.1105151142670193 1.1232566377713527 1.0126590832497016 1.0353977752824814 1.0241773332091966 1.069774524626111 0.9711692702217095 1.0 13.564893171056642 -8.267315905290399 24.858418342178098 0.9855846298091753 1.045393262741369 0.15390885909737073 0.05283517889894104 907.6381642898091 3839357.220206523 0.04834597929144611 0.013825359919081313 5.4036112191754934e-09 8.267315905290399 0.05980863293219363 KNQKPSQVNGAPGS(ph)PTEPAGQK ddPTM_A459_Selumetinib_30min_R2 1 KNQKPSQVNGAPGSPTEPAGQK 22 2 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 KNQKPSQVNGAPGS(0.943)PT(0.057)EPAGQK 55.337 0.010036 100870000.0 242540.0 177470.0 211970.0 264120.0 227620.0 197150.0 210530.0 229140.0 170480.0 210220.0 True False 229060.5977645472 191081.37834400884 198332.08097548602 228146.40036758606 199024.34065138144 224305.62295048757 220320.0621572806 229806.75946383097 204580.76360919065 204150.4023828452 1.1220188404771676 0.9359833540061905 0.9714998288543756 1.1175407822108572 0.9748907586189773 1.0987273124735022 1.079204643173381 1.1256738011854228 1.0021080596526986 1.0 17.63927288557158 -6.77519383679428 24.993738937124316 1.0701262369683509 1.0217124718844122 0.06150044063526017 0.06696091245942838 549.0396072902705 997675.6437838187 0.02298736085309344 0.020383955608732806 1.6780548919117945e-07 6.77519383679428 -0.04841376508393869 KNQKPSQVNGAPGSPT(ph)EPAGQK ddPTM_A459_Selumetinib_30min_R2 1 KNQKPSQVNGAPGSPTEPAGQK 22 2 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 KNQKPSQVNGAPGS(0.445)PT(0.555)EPAGQK 60.621 0.047828 36333000.0 27211.0 22390.0 24321.0 29276.0 25484.0 22883.0 26872.0 28354.0 21500.0 28573.0 True False 25698.72155426363 24107.241004802876 22756.213338702608 25288.558296083098 22282.472090149404 26034.925538808086 28121.60124585782 28436.505445742612 25800.600760192407 27748.02324843038 0.9261460293650765 0.8687912933101116 0.8201021433117711 0.911364318447931 0.8030291704260358 0.9382623513651842 1.0134632292211507 1.0248119367332293 0.9298176136439509 1.0 14.760097377993594 -6.982528920010058 5.9656414348979006 0.9920347857741096 0.8659573926400348 0.673261123878198 0.041542842583148616 0.09406773868203798 11.77380375882103 0.01470613869806612 0.012576428582227512 1.0410487810605468e-07 6.982528920010058 -0.12607739313407484 KNQS(ph)SEDILR ddPTM_A459_Selumetinib_30min_R1 1 KNQSSEDILR 10 1 Q13625-2;Q13625;Q13625-3;H0Y847 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 KNQS(0.918)S(0.082)EDILR 73.219 0.033815 20911000.0 7864.0 8246.0 10411.0 11533.0 10589.0 8306.0 9697.7 8666.9 4528.2 7964.4 True False 8047.215899319713 7280.554486538607 8997.243383529498 9518.97805122249 9631.226819639787 8222.449181244594 8966.194681336936 8437.025657941207 7684.024673357315 8986.708319825562 0.895457559423261 0.8101469667683536 1.0011722939400063 1.0592285531536267 1.071719085217482 0.9149567214844464 0.9977173356741343 0.9388338151944131 0.8550432928156354 1.0 13.133577062217483 -5.267858976233131 24.946142801103424 0.9820881742612515 0.8528022608864736 0.38562327294466703 0.06408632658091228 475.58556077224165 1848100.6909699985 0.017849248689795972 0.03862664876817313 5.396858404322332e-06 5.267858976233131 -0.1292859133747779 KNQS(ph)SEDILR ddPTM_A459_Selumetinib_30min_R2 1 KNQSSEDILR 10 1 Q13625-2;Q13625;Q13625-3;H0Y847 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 KNQS(0.761)S(0.239)EDILR 82.774 0.021454 12019000.0 77143.0 82609.0 89436.0 86137.0 77333.0 79123.0 54926.0 66100.0 45966.0 85830.0 True False 72855.70088789669 88944.84467019928 83681.78513055421 74404.99200538702 67617.73717420822 90021.47504291877 57480.167833804255 66292.3400565559 55160.48439734902 83351.86488687838 0.8740740352573197 1.0671008356071152 1.003958162713259 0.8926613952353234 0.8112324453205234 1.080017527683299 0.6896086597680077 0.795331216002486 0.6617786473309325 1.0 16.346926857500833 -7.270612140219034 24.948213540886634 0.7696238990710054 0.9528220945568622 0.333117758367521 0.11553721293550413 706.5597167509476 1921703.6220920586 0.04633736847597182 0.0317381888286201 5.36275380609738e-08 7.270612140219034 0.1831981954858568 KNQSS(ph)EDILR ddPTM_A459_Selumetinib_30min_R1 1 KNQSSEDILR 10 1 Q13625-2;Q13625;Q13625-3;H0Y847 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 KNQS(0.299)S(0.701)EDILR 112.02 0.015248 25316000.0 1910.9 2156.5 2530.0 2917.0 2466.7 2091.7 2741.6 2171.5 1068.4 1681.9 True False 1955.4202520358658 1904.0159774703498 2186.4398962952273 2407.600708871587 2243.5874205312566 2070.6593971116436 2534.7989047251776 2113.904765973917 1812.9967671513969 1897.788248093342 1.0303679844157667 1.003281572316229 1.152098975474153 1.2686350604660137 1.182211673396824 1.0910908523076697 1.335659501143936 1.1138780989384363 0.9553208947167141 1.0 10.890103312601608 -8.173724231817248 4.964746676311872 0.9787761960183784 1.1539024275482592 0.3402428651039645 0.0951054221196945 0.254422155753586 10.264841558103463 0.07432996224346929 0.02628363229296582 6.70310107626422e-09 8.173724231817248 0.17512623152988083 KNQTALDALHAQTVSQTAAS(ph)SPQDAYR ddPTM_A459_Selumetinib_30min_R2 1 KNQTALDALHAQTVSQTAASSPQDAYR 27 1 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 KNQTALDALHAQTVSQTAAS(0.5)S(0.5)PQDAYR 157.75 4.1673e-17 5626200.0 75750.0 77686.0 87974.0 94687.0 93329.0 69805.0 57680.0 66966.0 62217.0 82678.0 True False 71540.11825127594 83644.26640013934 82313.848618849 81790.46725581413 81604.1766481538 79420.00512330103 60362.23429075167 67160.85997318191 74662.13848822737 80290.87131675785 0.891011855744359 1.041765583414233 1.0251956077809923 1.0186770415423714 1.0163568449296658 0.9891536088826195 0.7517944854853408 0.8364694375805644 0.9298957311557324 1.0 16.29294834917632 -7.0980468784184945 9.55442218348275 0.8660341744406037 1.0035087879508682 0.3884084773731411 0.07137036735463463 0.36825906120334256 33.56216597362397 0.02657888230034142 0.020589883422344656 7.979085551351511e-08 7.0980468784184945 0.13747461351026447 KNQTALDALHAQTVSQTAASS(ph)PQDAYR ddPTM_A459_Selumetinib_30min_R2 1 KNQTALDALHAQTVSQTAASSPQDAYR 27 1 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 KNQTALDALHAQTVSQTAAS(0.26)S(0.74)PQDAYR 99.7 9.5777e-07 3671400.0 19276.0 22132.0 20758.0 28748.0 26717.0 17953.0 19088.0 18373.0 18273.0 24310.0 True False 18204.717087941837 23829.453234403634 19422.45287960154 24832.47280693389 23360.57160698956 20425.862788892246 19975.629822154442 18426.46238818611 21928.11059027888 23608.10713503456 0.7711214195959801 1.009375851189721 0.8227026744883971 1.051862085549517 0.9895148083398159 0.8652054428616242 0.846134326140468 0.7805141802682326 0.9288381514389794 1.0 14.526994752485225 -6.799655544165767 24.35623877234499 0.8680452025144519 0.9343150900634136 0.03782874405610814 0.09531296680087319 300.7846587961765 191696.08617703235 0.032563034092923555 0.028718593501664478 1.5861507314910442e-07 6.799655544165767 0.06626988754896168 KNS(ph)ITEISDNEDDLLEYHR ddPTM_A459_Selumetinib_30min_R2 3 KNSITEISDNEDDLLEYHR 19 1 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 KNS(0.956)IT(0.044)EISDNEDDLLEYHR;KNS(0.738)IT(0.262)EISDNEDDLLEYHR;KNS(0.5)IT(0.5)EISDNEDDLLEYHR 146.3 3.2144e-05 13708600.0 40915.0 35512.1 41058.0 47857.0 59177.0 41745.0 49893.0 48649.0 41766.0 42524.0 True False 38641.108095722164 38235.76388060117 38416.372980570384 41338.79404207024 51742.6562109077 47494.99482661991 52213.123361103906 48790.56053572447 50120.36703954401 41296.22162937926 0.9357056546846849 0.9258901267955033 0.9302636286037347 1.001030903337188 1.2529634472442042 1.1501050932182784 1.2643559459192282 1.1814775931223096 1.2136792438145725 1.0 15.333722168799035 -6.107967936210756 4.099715317274522 1.1886042018386263 0.9339502325982867 0.7256796074664946 0.0695444951940097 0.10879664389837534 3.147868325324135 0.019512114458897445 0.02603312660297654 7.798876871962384e-07 6.107967936210756 -0.25465396924033956 KNS(ph)STDQGS(ph)DEEGSLQK ddPTM_A459_Selumetinib_30min_R2 2 KNSSTDQGSDEEGSLQK 17 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 2 KNS(0.938)S(0.023)T(0.04)DQGS(0.996)DEEGS(0.003)LQK;KNS(0.977)S(0.017)T(0.006)DQGS(1)DEEGSLQK 131.33 0.0019405 35108000.0 146555.0 111512.0 131753.0 128112.0 118129.0 111468.0 142173.0 144720.0 111866.0 133646.0 True False 138410.05980614832 120064.61183240659 123276.15542181995 110662.92459447293 103288.57893334095 126821.70519424275 148784.32621045504 145141.11124031415 134242.32579719447 129787.2927259902 1.0664376835285616 0.9250875745277286 0.9498322434545521 0.8526483777430117 0.7958296745691897 0.9771504014803015 1.146370519682322 1.1182998596537432 1.0343256491266046 1.0 16.985789612638023 -7.034925093860476 7.160645302943834 1.0820692927816251 0.9135042603310309 0.48878588060146 0.07541869095883626 0.19007004919249526 31.50903370794348 0.029894146619779353 0.023646344128826227 9.227305639315644e-08 7.034925093860476 -0.16856503245059418 KNS(ph)TGSGHSAQELPTIR ddPTM_A459_Selumetinib_30min_R1 4 KNSTGSGHSAQELPTIR 17 1 O94763-2;O94763-3;O94763;I3L280;O94763-4 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 KNS(0.849)T(0.146)GS(0.005)GHSAQELPTIR;KNS(0.995)T(0.005)GSGHSAQELPTIR;KNS(0.811)T(0.15)GS(0.038)GHS(0.001)AQELPTIR;KNS(0.833)T(0.164)GS(0.003)GHSAQELPTIR 148.19 0.00018205 96974000.0 8018.990000000001 8853.21 9333.3 9759.1 10122.599999999999 8865.6 10204.400000000001 9279.800000000001 3376.2400000000002 5994.26 True False 8205.816864761671 7816.672057454333 8065.889124147135 8054.856385995448 9207.012617290184 8776.42011332074 9434.673892390425 9033.669558961432 5729.232689186854 6763.681660036862 1.2132174867492136 1.155683021517564 1.1925293840785487 1.1908982105984494 1.3612427491509123 1.297580305290848 1.3949021208575043 1.335614242807548 0.8470583000731631 1.0 12.723593044011709 -8.260618687087607 24.999999109830096 0.9235291231465423 1.2672612826986445 0.7325480361745704 0.08318551335065547 39.92140023616817 1216194.0977404027 0.07177916532854722 0.023468758290660384 5.4875856646546125e-09 8.260618687087607 0.3437321595521021 KNS(ph)TGSGHSAQELPTIR ddPTM_A459_Selumetinib_30min_R2 2 KNSTGSGHSAQELPTIR 17 1 O94763-2;O94763-3;O94763;I3L280;O94763-4 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 KNS(0.996)T(0.004)GSGHSAQELPTIR;KNS(0.995)T(0.005)GSGHSAQELPTIR 150.13 0.00013887 104945000.0 42758.0 39565.0 47104.0 61145.0 59345.0 40213.0 49641.0 48354.0 55871.0 71960.0 True False 40381.68153383571 42599.5082784737 44073.37992295742 52816.94551899166 51889.55054896862 45751.97573273124 51949.404861775394 48494.70213456435 67046.76116617252 69882.32782546649 0.5778525528612949 0.6095891422630831 0.630679905698508 0.7557983135722639 0.7425275053596462 0.6547002247406293 0.7433840067766605 0.6939480072226777 0.9594236948377579 1.0 16.09264004570798 -12.143766941996697 0.052747179173404234 2.0927690086367936 1.1461662253362872e-08 0.759576847274289 0.06588645132447228 151.40976584182866 0.9439685075540433 30.3376197995821 11.049328374088836 7.181795888185365e-13 12.143766941996697 -2.0927689971751313 KNS(ph)VHEQEAINSDPELSNCENFQK ddPTM_A459_Selumetinib_30min_R2 2 KNSVHEQEAINSDPELSNCENFQK 24 1 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 KNS(1)VHEQEAINSDPELSNCENFQK;KNS(0.647)VHEQEAINS(0.13)DPELS(0.223)NCENFQK 112.53 1.3349e-07 13600600.0 70017.0 63961.0 69860.0 78153.0 69279.0 61176.0 62763.0 55937.0 60315.0 75721.0 True False 66125.73544025849 68866.60303296991 65365.283657816915 67508.42657855526 60575.55265788184 69602.43869956397 65681.60386252515 56099.76740913114 72379.68534190726 73534.73798321479 0.899244863772446 0.9365179630977888 0.8889034686264518 0.9180481012112247 0.8237678452285906 0.946524603316756 0.8932051118141985 0.7629015747895451 0.9842924218813266 1.0 16.16613832305923 -8.491002193097373 24.94250429153501 1.0000001545255002 0.8862969176697013 0.41621462793374653 0.05149381252744209 500.34035921910555 391502.7990348342 0.04886210005474112 0.012616139971902389 3.2284778185257567e-09 8.491002193097373 -0.11370323685579886 KNSS(ph)QDDLFPTSDTPR ddPTM_A459_Selumetinib_30min_R1 1 KNSSQDDLFPTSDTPR 16 1 Q9H6T3-3;Q9H6T3-2;Q9H6T3 Q9H6T3-3 RPAP3 RNA polymerase II-associated protein 3 1 KNS(0.254)S(0.746)QDDLFPTSDTPR 102.47 0.0025284 9871700.0 2498.3 2664.3 2433.8 2736.5 2271.2 2201.6 2469.9 1941.7 1244.1 1774.1 True False 2556.5055291544318 2352.3625174005347 2103.303327906454 2258.6216454669516 2065.770361012928 2179.453902892862 2283.5934544721017 1890.1998084695156 2111.146834531126 2001.8230161973943 1.2770886878954446 1.175110136294174 1.0506939479104545 1.1282823842026577 1.03194455468746 1.088734561076678 1.1407569180665884 0.9442392225363084 1.0546121297682949 1.0 10.967098713910321 -1.5228787452904764 0.5320996187312437 1.040029284430499 10.455640969767986 0.6489626101815382 0.053584915834999435 79.27510851474906 0.7675254717667114 0.027697094580393662 846.8658232310879 0.029999999999299636 1.5228787452904764 9.415611685337486 KNSS(ph)QDDLFPTSDTPR ddPTM_A459_Selumetinib_30min_R2 2 KNSSQDDLFPTSDTPR 16 1 Q9H6T3-3;Q9H6T3-2;Q9H6T3 Q9H6T3-3 RPAP3 RNA polymerase II-associated protein 3 1 KNS(0.216)S(0.781)QDDLFPT(0.001)S(0.001)DTPR;KNS(0.08)S(0.915)QDDLFPT(0.004)SDTPR 210.2 4.2125e-29 4309700.0 25411.0 25801.0 26764.0 27289.0 29400.0 21839.0 21972.0 22067.0 17085.8 28052.0 True False 23998.7583482927 27779.85373670919 25042.0333784399 23572.19112384928 25706.509160665217 24847.12401529648 22993.74153669203 22131.21131661149 20503.437417139317 27242.06587215094 0.8809448762410559 1.0197410823056565 0.9192413488743492 0.865286474031571 0.9436328831046733 0.9120866285217096 0.8440527838308366 0.8123910800478542 0.752638860553509 1.0 14.733548492242159 -7.236320947425592 3.629627589457689 0.8352316628041627 0.9272380126090426 0.18487560432282468 0.07028097615671648 0.3215217033812143 9.16440127841818 0.02877063683995717 0.0205267474796993 5.803353860790654e-08 7.236320947425592 0.09200634980487987 KNSSQSLMVPQS(ph)GSPEPESIR ddPTM_A459_Selumetinib_30min_R2 2 KNSSQSLMVPQSGSPEPESIR 21 1 F5H1U9;O75970-5;O75970-3;O75970-2;O75970;A0A075B6R8;B7ZB24;H0YGQ3 F5H1U9 MPDZ Multiple PDZ domain protein 1 KNSSQSLMVPQS(0.562)GS(0.42)PEPES(0.017)IR;KNSSQSLMVPQS(0.495)GS(0.495)PEPES(0.011)IR 75.529 0.0021425 7821000.0 36858.0 37170.0 43719.0 46778.0 41347.0 33352.0 31479.0 33513.0 26385.0 36914.0 True False 34809.579914264395 40020.81947961245 40906.167137648095 40406.75570344906 36152.6202131301 37945.935260688144 32942.83587445514 33610.5172816242 31662.737258496607 35848.19690590975 0.9710273575440518 1.1163969999566374 1.141094132154371 1.127162847534678 1.0084920116908354 1.0585172626752832 0.9189537750230432 0.9375790188232129 0.8832449046628856 1.0 15.12961293556668 -7.056658148136004 1.596066187318251 0.9262555279091826 1.087792194841495 0.5627835732846828 0.057423374095663345 0.2701112962088915 1.378790372556085 0.029018584050296795 0.02076367713474431 8.776914179698719e-08 7.056658148136004 0.1615366669323124 KNSSQSLMVPQSGS(ph)PEPESIR ddPTM_A459_Selumetinib_30min_R2 2 KNSSQSLMVPQSGSPEPESIR 21 1 F5H1U9;O75970-5;O75970-3;O75970-2;O75970;A0A075B6R8;B7ZB24;H0YGQ3 F5H1U9 MPDZ Multiple PDZ domain protein 1 KNSSQSLMVPQS(0.242)GS(0.67)PEPES(0.088)IR;KNSSQSLMVPQS(0.278)GS(0.543)PEPES(0.179)IR 112.55 4.7935e-05 24640000.0 190724.0 190194.0 212857.0 219686.0 216540.0 161016.0 167890.0 153463.0 128930.0 195632.0 True False 180124.32360866482 204781.26822990066 199162.01236117812 189764.3878205118 189336.30930783815 183194.4924422813 175697.2176677236 153909.55192283262 154719.6026051909 189983.595847021 0.948104612956715 1.0778892109969067 1.048311626449832 0.9988461739260598 0.9965929345831307 0.9642647915233353 0.9248020434837905 0.8101202171516113 0.8143840099214384 1.0 17.535515328720123 -7.182252275540623 1.631395229007351 0.8616857777101675 1.0204540195817668 0.5001764604705159 0.0596483315320794 0.279535161581966 1.4625330245503734 0.031218374579303734 0.020241926541078394 6.572759241259685e-08 7.182252275540623 0.15876824187159932 KNSSTDQGS(ph)DEEGSLQK ddPTM_A459_Selumetinib_30min_R1 4 KNSSTDQGSDEEGSLQK 17 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 KNSSTDQGS(1)DEEGSLQK;KNSSTDQGS(1)DEEGSLQK;KNS(0.063)S(0.017)T(0.002)DQGS(0.917)DEEGS(0.002)LQK;KNS(0.093)S(0.093)T(0.023)DQGS(0.788)DEEGS(0.002)LQK 127.5 0.0005583999999999999 66475800.0 14052.3 15836.4 14316.199999999999 14780.1 13338.900000000001 11954.900000000001 13256.699999999999 13171.900000000001 6797.4 12747.699999999999 True False 14379.691248984022 13982.266925857382 12372.138673257597 12199.03299183851 12132.398850174062 11834.644560180714 12256.736445969591 12822.538423638875 11534.69133754671 14383.991468113145 0.9997010413181449 0.9720714140336973 0.8601325091637129 0.848097902371653 0.8434653814325127 0.8227649874804293 0.8521095464454831 0.8914450799045769 0.8019117199226066 1.0 13.8121764497779 -5.216981874545059 3.7371292931467877 0.8571714393505186 0.9934741878602603 0.469527551132944 0.05118821577225921 0.1700460711204654 4.983472151896762 0.0123506711895109 0.035916093053272556 6.067616525017688e-06 5.216981874545059 0.13630274850974167 KNSSTDQGS(ph)DEEGSLQK ddPTM_A459_Selumetinib_30min_R2 7 KNSSTDQGSDEEGSLQK 17 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 KNSSTDQGS(1)DEEGSLQK;KNSSTDQGS(0.995)DEEGS(0.004)LQK;KNSSTDQGS(1)DEEGSLQK;KNSST(0.001)DQGS(0.999)DEEGSLQK;KNSSTDQGS(0.981)DEEGS(0.019)LQK;KNSSTDQGS(0.993)DEEGS(0.007)LQK;KNSSTDQGS(0.998)DEEGS(0.001)LQK 137.43 0.00026259 149747400.0 256854.1 196651.2 250615.0 259926.0 260052.0 195670.2 205581.0 204317.4 151902.4 191295.9 True False 242579.17739042977 211733.7147067299 234490.70374898 224523.63040264035 227381.94286562307 222621.99393277467 215140.92385102328 204911.92980743365 182287.12450767696 185772.6903205622 1.305784919041892 1.1397461830442912 1.2622452920520875 1.208593308387853 1.223979382939772 1.19835694659224 1.1580869259081321 1.103025043421859 0.9812374692594984 1.0 17.50317890707808 -7.884398275094097 1.3151426877101788 0.9833291409673545 1.2226805064021966 0.8272258454848342 0.04173482660559325 0.1650698002006236 0.5152271758601422 0.03361640107466285 0.012110570027125048 1.304973597139183e-08 7.884398275094097 0.23935136543484214 KNSTDLDSAPEDPT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 KNSTDLDSAPEDPTSPK 17 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 KNSTDLDSAPEDPT(0.695)S(0.305)PK 73.593 0.030903 4811500.0 58398.0 50366.0 45315.0 39888.0 41727.0 32057.0 32308.0 20127.0 10952.0 8397.6 True False 55152.472945716305 54228.91024778482 42399.48223524153 34455.185589362016 36484.88121588698 36472.56076552773 33810.38601708747 20185.56623779579 13142.706024447785 8155.139468414903 6.762909838553156 6.649660678130031 5.199111848357221 4.2249658295615875 4.473851288159326 4.472340529157967 4.1458991778173875 2.4751957113639915 1.6115856847513002 1.0 12.993493834642777 -5.305784984422485 0.18168063245144445 1.3532901677543115e-10 11.661798047665451 0.9152282892466186 0.5332064052741738 4.193180325231776 0.1700857667004375 1.8756401942425265 11.572302715703326 4.9455547667883295e-06 5.305784984422485 11.661798047530123 up KNSTDLDSAPEDPTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KNSTDLDSAPEDPTSPK 17 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 KNSTDLDSAPEDPT(0.24)S(0.76)PK 118.23 0.00079701 8921700.0 5544.6 6966.9 7008.9 6836.5 4770.8 3945.3 2444.0 1622.3 1273.6 5582.9 True False 5673.778392086478 6151.212109176063 6057.129877131863 5642.633611998838 4339.281982353149 3905.6138640457875 2259.6471123243127 1579.2713340269333 2161.2061799363714 6299.519597051147 0.9006684247386764 0.9764573336759667 0.9615225072031289 0.8957244318503585 0.6888274439822999 0.6199859852605324 0.358701497393876 0.25069710629461367 0.34307476096241507 1.0 12.621026097182847 -6.600359554550438 1.5193198592205277 0.4336410838136713 0.9491215379634576 0.49698883528782944 0.19625089525422934 0.28060228388434144 1.3361252208060461 0.07885965882156384 0.08168455460778319 2.509807688923602e-07 6.600359554550438 0.5154804541497863 KNSTDLDSAPEDPTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KNSTDLDSAPEDPTSPK 17 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 KNSTDLDSAPEDPT(0.258)S(0.742)PK 94.188 0.011213 0.0 40026.0 37318.0 35776.0 34711.0 36271.0 26224.0 23262.0 13013.0 8006.8 9689.7 True False 37801.51515677321 40180.170603717444 33474.21110996361 29983.301920185146 31714.312713145853 29836.117962229728 24343.72909277855 13050.865675581877 9608.383728684123 9409.933184135929 4.017192727840219 4.26997406011943 3.557327183406286 3.186345889334641 3.370301583715021 3.170704550009984 2.587024648997433 1.3869243723838702 1.0210894743527785 1.0 13.199968763699005 -7.526850815065978 0.8584643390848439 0.7802884508835586 3.8215965441897644 0.9410405027112482 0.27956268689116354 0.14791306431798384 0.2023758442679577 0.26950709513630633 0.1323261324085793 2.972687007071736e-08 7.526850815065978 3.0413080933062058 up KNT(ph)FTAWSDEESDYEIDDR ddPTM_A459_Selumetinib_30min_R1 1 KNTFTAWSDEESDYEIDDR 19 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 KNT(0.5)FT(0.5)AWS(0.001)DEESDYEIDDR 87.411 0.004195 7455300.0 3047.9 4622.2 2472.1 3058.2 3244.4 2964.9 3887.5 3722.7 2111.1 3155.2 True False 3118.910139818993 4081.030675197517 2136.4023982732942 2524.142779523856 2950.944592845343 2935.075797913811 3594.262745155793 3623.9619029661994 3582.3825113565267 3560.2006542506147 0.8760489766483376 1.146292322126583 0.600079210626117 0.7089889095184052 0.8288703023865058 0.824413026948228 1.0095674638069938 1.0179094536819038 1.006230507564069 1.0 11.797742838981417 -7.262482764690852 22.717500611358343 1.0099193286044923 0.8290140405619829 0.308264739238042 0.1303426789806652 36.22640151610913 788709.3859742987 0.05611801859695152 0.04031503641733131 5.46408234080847e-08 7.262482764690852 -0.18090528804250938 KNTFTAWS(ph)DEESDYEIDDR ddPTM_A459_Selumetinib_30min_R1 1 KNTFTAWSDEESDYEIDDR 19 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 KNT(0.005)FT(0.006)AWS(0.988)DEES(0.001)DYEIDDR 83.82600000000002 0.0022135 9295200.0 2103.1 3158.2 1630.4 1930.9 1817.2 2302.8 2747.0 2204.6 1247.9 2233.5 True False 2152.0981380797675 2788.436475792654 1409.000635146143 1593.704562482054 1652.8345808527185 2279.635922775108 2539.7915783776116 2146.1268464499644 2117.595156990107 2520.1914811323386 0.8539423112059785 1.1064383387804293 0.5590847543509153 0.6323743947289243 0.6558369049442581 0.9045486979230851 1.0077772254179935 0.8515729310717675 0.8402516923192906 1.0 11.299317636794125 -6.874346417846083 8.5888036077615 0.9185320686450174 0.7625117623539895 0.2229139168938582 0.14885959545141264 0.4700766106321807 33.62981566397848 0.057478007903634325 0.05071014251526922 1.3355297974488825e-07 6.874346417846083 -0.1560203062910278 KNTFTAWS(ph)DEESDYEIDDR ddPTM_A459_Selumetinib_30min_R2 2 KNTFTAWSDEESDYEIDDR 19 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 KNT(0.001)FT(0.001)AWS(0.958)DEES(0.04)DYEIDDR;KNT(0.024)FT(0.073)AWS(0.778)DEES(0.097)DY(0.027)EIDDR 64.619 0.012989 6447800.0 28988.0 23373.4 31052.0 28739.0 29164.0 24573.3 25146.7 27185.5 24722.0 25844.0 True False 27376.963008158225 25166.06462267349 29054.148126861313 24824.698622459764 25500.157590531984 27958.049020792394 26316.071377240725 27264.60530419819 29667.090790394264 25097.816569223887 1.0908105465130036 1.002719282502578 1.1576364839038973 0.9891178602723939 1.0160309172791335 1.1139633977194596 1.0485402706110587 1.086333754531911 1.182058634804648 1.0 14.61527423927251 -6.770998089399723 24.99765424520163 1.089222632111879 1.051023269600781 0.07112737150070758 0.0626052208809127 556.0294232374579 1454102.3704957494 0.021404375836803408 0.019115696865425472 1.694345254397417e-07 6.770998089399723 -0.0381993625110979 KNTFTAWS(ph)DEESDYEIDDRDVNK ddPTM_A459_Selumetinib_30min_R1 1 KNTFTAWSDEESDYEIDDRDVNK 23 2 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 KNT(0.005)FT(0.046)AWS(0.878)DEES(0.064)DY(0.007)EIDDRDVNK 103.31 3.3691e-05 6423000.0 346.71 457.43 576.81 598.16 462.29 274.92 435.0 381.2 253.63 377.42 True False 354.7876684197782 403.8738829465626 498.4823701905338 493.70258485383204 420.4759511239284 272.1545544073878 402.18759977949077 371.0893376878917 430.39158559772466 425.86553338212065 0.8330978691845303 0.9483601073303451 1.1705158814607697 1.1592921853359814 0.9873444037243646 0.6390621759079737 0.944400446275646 0.8713767811656189 1.0106278904039478 1.0 8.734254162605383 -6.536126616268138 24.995640907243267 0.8799214303481787 1.0374569625886636 0.18578464780182447 0.1326635453439498 357.82402711706567 675125.686392665 0.04553087420096886 0.04555246524581367 2.909868637516841e-07 6.536126616268138 0.1575355322404849 KPAFNLSAFGTLS(ph)PSLGNSSILK ddPTM_A459_Selumetinib_30min_R1 1 KPAFNLSAFGTLSPSLGNSSILK 23 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 KPAFNLSAFGT(0.002)LS(0.995)PS(0.003)LGNSSILK 109.44 8.641699999999999e-06 16235000.0 4109.2 4352.9 4837.4 4679.6 3887.9 3975.7 3626.4 3807.6 2059.3 3265.9 True False 4204.936364888677 3843.2604443916916 4180.507649936179 3862.395706971371 3536.2401314644944 3935.7080676467763 3352.8577283686095 3706.610079172131 3494.481694678839 3685.1100775599302 1.141061264490896 1.0429160495896175 1.1344322318600244 1.048108638732667 0.9596023068613437 1.0680028506103074 0.9098392335104086 1.0058342902002093 0.9482706408034046 1.0 11.84749199922746 -6.036038370004005 4.141269345377367 0.9834402420685476 1.0996148151718772 0.592539797462861 0.04627839550194391 0.1501209767699819 5.678751765382462 0.013060595211157058 0.01812366857760871 9.203682534424144e-07 6.036038370004005 0.11617457310332957 KPALPVS(ph)PAAR ddPTM_A459_Selumetinib_30min_R1 1 KPALPVSPAAR 11 1 A0A087X0M4;Q9BWU0;A0A087WWF4 A0A087X0M4 SLC4A1AP Kanadaptin 1 KPALPVS(1)PAAR 102.97 0.024698 87016000.0 3211.1 4143.5 2748.9 2873.8 2989.7 3071.4 3383.2 3248.4 1595.8 2539.3 True False 3285.91238228707 3658.377093739108 2375.614478626859 2371.9447779071547 2719.2821628744073 3040.5045046080713 3128.0025001700546 3162.2418797097266 2707.956047379447 2865.2438898765836 1.1468176911210886 1.2768117599569115 0.829114228991231 0.8278334651677149 0.9490578350004043 1.0611677823834524 1.0917054953757492 1.1036553959271982 0.9451049025694245 1.0 11.484442231232372 -5.247759142108961 24.9537928474393 0.9805834718402601 1.211814743030006 0.49304408796807553 0.09557352367212932 730.2048275298995 1331943.5275249698 0.027574601248044117 0.07211362906702 5.652503733765592e-06 5.247759142108961 0.23123127118974585 KPALPVS(ph)PAAR ddPTM_A459_Selumetinib_30min_R2 2 KPALPVSPAAR 11 1 A0A087X0M4;Q9BWU0;A0A087WWF4 A0A087X0M4 SLC4A1AP Kanadaptin 1 KPALPVS(1)PAAR;KPALPVS(1)PAAR 89.13600000000002 0.015228 322880000.0 1351770.0 1299900.0 1380960.0 1527460.0 1642770.0 1102170.0 1061020.0 1079050.0 1011990.0 1325810.0 True False 1276644.0349640574 1399598.1501627208 1292110.5370755638 1319417.3129845306 1436390.546049863 1253983.9129969026 1110359.5323712442 1082189.8568536572 1214416.277363119 1287530.4204319245 0.9915447547528896 1.087040840319098 1.003557288100504 1.0247659333298773 1.115616783305206 0.9739450758578829 0.8623947945235769 0.8405159518410584 0.9432136577834968 1.0 20.296175088523185 -7.008867181921094 5.950400509575734 0.9002583841173631 1.0439886788256452 0.5762363444766545 0.053457832837551816 0.10442916559782142 14.4809290530457 0.01931994969497436 0.01591862384754462 9.797895836734952e-08 7.008867181921094 0.14373029470828202 KPAPPQHFS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 KPAPPQHFSPR 11 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 KPAPPQHFS(1)PR 83.869 0.019134 15883000.0 1428.1 1667.0 1649.0 1920.0 1809.8 1517.9 1688.5 1728.4 1141.9 1198.2 True False 1461.3719514011298 1471.826865032726 1425.0748573086296 1584.7080428637114 1646.1039095461424 1502.6313041429287 1561.1350855808512 1682.5572173655614 1937.7208989237922 1352.000641456354 1.0808959009272086 1.0886288215420497 1.0540489505785746 1.1721207773664135 1.2175318998169888 1.1114131591863134 1.1546851663466822 1.244494392808229 1.4332248369619924 1.0 10.400880120768635 -6.110014618459367 0.7384107400897604 1.2207294045959396 1.0609168694598756 0.17606882045257888 0.10571149112384434 1.3186417145226534 1.4789547362910702 0.05966717018115525 0.12959219776033884 7.762209883990512e-07 6.110014618459367 -0.15981253513606397 KPAPPQHFS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 KPAPPQHFSPR 11 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 KPAPPQHFS(1)PR;KPAPPQHFS(1)PR 109.99 0.0062399 13434700.0 78078.0 67809.0 81030.0 86635.0 110654.0 80921.0 77036.0 87738.0 81476.0 97137.0 True False 73738.73733099826 73009.73225969991 75816.6180187932 74835.16354628919 96752.65526068868 92067.13322229985 80618.32664393804 87993.30305419213 97773.4766296483 94332.40241776445 0.7816904418954135 0.7739623966785659 0.8037176630255694 0.793313449337069 1.0256566437501062 0.975986308655296 0.8546196702052422 0.9328004036672499 1.0364781784804395 1.0 16.525465789664317 -6.24640387764178 24.160966150642718 0.9620014961550217 0.7882665346616363 0.7675248685853711 0.04912620521902032 276.7190476554974 444666.8817875195 0.015432935288700175 0.019833200836536335 5.670170554693711e-07 6.24640387764178 -0.1737349614933854 KPASFMTSICDER ddPTM_A459_Selumetinib_30min_R1 1 KPASFMTSICDER 13 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 122.34 0.013244999999999998 22026000.0 1911.8 2294.9 2633.6 2611.0 2067.3 1791.0 1828.0 1821.8 826.13 1689.7 False True 1956.3412202847694 2026.2120411299343 2275.971585329295 2155.0378645401847 1880.3130800114584 1772.9841660978905 1690.1124882687573 1773.4799459596038 1401.8822718520998 1906.5894540717754 1.026094640409734 1.0627416598799961 1.1937397327299042 1.130310387450122 0.9862181268210625 0.929924458729931 0.8864585318351034 0.9301844936633324 0.7352827158768731 1.0 10.89677850621558 -6.575495136812086 2.173991933358898 0.886629268678501 1.1062802636076086 0.6277164254057506 0.07489153327000266 0.20128225006421485 1.9287484579053171 0.027762417346477518 0.02889408307871255 2.6576933099822164e-07 6.575495136812086 0.21965099492910756 KPATPAEDDEDDDIDLFGS(ph)DNEEEDKEAAQLR ddPTM_A459_Selumetinib_30min_R1 4 KPATPAEDDEDDDIDLFGSDNEEEDKEAAQLR 32 2 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;P29692-3;E9PL71;P29692-4;E9PQZ1;H0YE72 P29692 EEF1D Elongation factor 1-delta 1 KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR 137.58 2.3445999999999996e-19 665645000.0 34132.299999999996 40213.3 30124.7 29209.8 27867.199999999997 30680.0 33644.8 34224.9 21446.4 34353.1 True False 34927.51618010558 35505.10814134402 26033.931203132342 24108.856765854413 25346.616680353774 30371.387055211184 31106.94564841613 33317.14447385709 36392.97441691851 38762.65501253072 0.9010609868909815 0.9159617195949648 0.6716240462557689 0.6219609249691693 0.653892688004989 0.7835218471333579 0.8024978071899425 0.8595165749891677 0.9388669172726644 1.0 15.242379769761412 -8.06440704113649 1.2872209658556713 0.9940600131556597 0.7514261089605834 0.4585953286600778 0.09133223624820655 0.4549720756823556 1.371661549312353 0.09589614667018653 0.03206288782983809 8.62170102754219e-09 8.06440704113649 -0.24263390419507636 KPATPAEDDEDDDIDLFGS(ph)DNEEEDKEAAQLR ddPTM_A459_Selumetinib_30min_R2 3 KPATPAEDDEDDDIDLFGSDNEEEDKEAAQLR 32 2 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;P29692-3;E9PL71;P29692-4;E9PQZ1;H0YE72 P29692 EEF1D Elongation factor 1-delta 1 KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLR 108.38 3.0642e-12 299462000.0 379571.0 328179.0 345446.0 327549.0 303182.0 270467.0 314163.0 338875.0 235073.0 304137.0 True False 358475.9633631025 353349.27403819526 323220.3804531659 282936.2611464588 265093.5666785305 307721.37419502705 328772.2020021747 339861.07014622376 282094.16848840535 295355.7745671744 1.2137090053120745 1.1963513310549176 1.0943425126081432 0.9579506666530708 0.8975398130170595 1.0418667948712825 1.1131395771217611 1.150683681889305 0.9550995537561333 1.0 18.17209429312838 -5.395664513314732 3.1924992633396285 1.0230804697784162 1.2073127975689468 0.5231080836843598 0.07114665075333243 0.2264282906916832 4.2864539315203185 0.021707498892347302 0.051905812908404805 4.021013087948717e-06 5.395664513314732 0.18423232779053067 KPATPAEDDEDDDIDLFGS(ph)DNEEEDKEAAQLREER ddPTM_A459_Selumetinib_30min_R1 5 KPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREER 35 3 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;P29692-3;E9PL71;P29692-4;E9PQZ1;H0YE72 P29692 EEF1D Elongation factor 1-delta 1 KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLREER;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLREER;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLREER;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLREER;KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLREER 64.542 6.4761e-05 150246600.0 5054.19 7576.4800000000005 19017.54 22993.089999999997 10425.43 11069.48 6488.46 5583.11 4513.429999999999 3948.17 True False 5171.9427932582275 6689.422199390004 16435.062523869707 18977.77846525479 9482.451697259157 10958.131081483682 5999.030238310881 5435.027786302847 7658.961062115435 4454.956077932512 1.1609413657021865 1.5015686086167832 3.6891637619684476 4.25992493152977 2.1285174379676133 2.459761867409748 1.3465969435763672 1.2199958184156046 1.7192001286059504 1.0 12.12119549273671 -7.200621887849959 2.7793545864971216 1.3163905360477557 2.633840885859783 0.31003692326973475 0.8803018021747674 0.3882872633428949 5.906794794799895 0.4326457547817438 0.3061785232782902 6.300544918786026e-08 7.200621887849959 1.3174503498120274 KPATPAEDDEDDDIDLFGS(ph)DNEEEDKEAAQLREER ddPTM_A459_Selumetinib_30min_R2 1 KPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREER 35 3 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;P29692-3;E9PL71;P29692-4;E9PQZ1;H0YE72 P29692 EEF1D Elongation factor 1-delta 1 KPATPAEDDEDDDIDLFGS(1)DNEEEDKEAAQLREER 52.234 0.003117 3187900.0 10260.0 18821.0 12283.0 14701.0 9915.5 5201.2 1299.7 2360.1 4670.9 14292.0 True False 9689.790274034205 20264.510180946614 11492.725152719224 12698.698439360482 8669.826244305312 5917.6180882073395 1360.1386253066912 2366.9675002644126 5605.210515850358 13879.352824924461 0.6981442431979491 1.4600471964770378 0.828044743705964 0.91493447854112 0.6246563765376789 0.426361240531368 0.09799726561199325 0.1705387513468082 0.40385244085621586 1.0 13.760652678154402 -6.370355818707191 1.5886294412027944 0.341889589155979 1.0406103856833198 0.4350093014200246 0.2937406461431784 0.3042144500682151 1.5348878421336405 0.10671320719618978 0.132427190571423 4.262301641188522e-07 6.370355818707191 0.6987207965273408 KPCARAECDT(ph)RR ddPTM_A459_Selumetinib_30min_R1 1 KPCARAECDTRR 12 3 A0A087WVV4;Q96H55-3;Q96H55-4;Q96H55 A0A087WVV4 MYO19 Unconventional myosin-XIX 1 KPCARAECDT(1)RR 92.611 0.025313 15034000.0 2339.1 1217.3 2742.5 2459.9 1626.6 1331.2 1231.8 1505.5 1175.9 1061.0 True False 2393.5964789037052 1074.777950092583 2370.0835634741748 2030.3246430418997 1479.4743171995553 1317.8093366328922 1138.8843342721298 1465.5692494468015 1995.4164156620452 1197.1896850151834 1.9993460592448626 0.8977507604226912 1.9797059673497905 1.6959089010327966 1.2357893955466146 1.100752331169792 0.9512981514351135 1.2241746381470153 1.6667504244632196 1.0 10.225436038405634 -6.313508116563453 6.177189343189224 1.1881341941089514 1.6137057208092411 0.29571225650315713 0.3366127061991572 0.3047265664849109 27.31160851129425 0.1038624443512848 0.11893535227504728 4.858384509799327e-07 6.313508116563453 0.42557152670028975 KPDAEVLTVES(ph)PEEEAMTK ddPTM_A459_Selumetinib_30min_R2 1 KPDAEVLTVESPEEEAMTK 19 1 Q8IVF2;Q8IVF2-3;Q8IVF2-2 Q8IVF2 AHNAK2 Protein AHNAK2 1 KPDAEVLTVES(1)PEEEAMTK 113.89 0.00026267 5534600.0 68089.0 54082.0 59885.0 57780.0 54119.0 40288.0 55036.0 55123.0 47659.0 53007.0 True False 64304.885961863016 58229.91549896153 56032.0642978581 49910.26432394047 47320.087390001405 45837.30630194904 57595.2830517651 55283.39880389608 57192.131703721374 51476.55018127422 1.2492073718113184 1.1311930440929974 1.0884968806289792 0.9695728277862815 0.9192552186066107 0.8904502368657838 1.118864470306262 1.0739530642441282 1.1110327227119878 1.0 15.651627750840433 -5.047562749306129 1.6163081222371476 1.0126308318903792 1.2676545433324438 0.5060113424738647 0.07305755409557865 0.5788624271773873 2.112628039923294 0.023666692300986898 0.19870729363213943 8.962666789502207e-06 5.047562749306129 0.2550237114420646 KPEEMPTACPGHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 KPEEMPTACPGHSPR 15 1 C9J8F8;C9J6I8;Q9NZC9 C9J8F8 SMARCAL1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 1 KPEEMPTACPGHS(1)PR;KPEEMPT(0.001)ACPGHS(0.999)PR 113.33 0.0014321 15951700.0 54435.0 43466.0 49609.0 60151.0 55967.0 42908.0 44259.0 51657.0 36065.0 43070.0 True False 51409.72062057035 46799.7024347817 46417.21095019524 51958.33003373729 48935.92510867176 48818.18751995704 46317.1311975447 51807.313317723296 43279.007740294874 41826.45719070084 1.2291196547241903 1.11890190033084 1.1097571744736496 1.2422359798928664 1.1699753791136664 1.1671604720758098 1.1073644364945703 1.2386254250871973 1.0347280321393553 1.0 15.352128182698353 -8.401133527395103 5.453962748029068 1.0019459543297002 1.1684966967085066 0.6204741064147659 0.0488330549518323 0.13948259893075746 5.22918763469955 0.04575582840203177 0.01189348507775295 3.970694484462088e-09 8.401133527395103 0.1665507423788064 KPEKPLFSSAS(ph)PQDSSPR ddPTM_A459_Selumetinib_30min_R1 1 KPEKPLFSSASPQDSSPR 18 2 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 KPEKPLFS(0.078)S(0.351)AS(0.549)PQDS(0.017)S(0.004)PR 88.76799999999999 0.0072085 16358000.0 4377.2 5823.2 6040.2 6587.5 5421.1 4780.7 5038.5 5265.3 2974.3 4718.2 True False 4479.1802434514575 5141.417036867763 5219.974016443652 5437.11678768995 4930.762462172942 4732.6104985282955 4658.441888480381 5125.6471398952135 5047.169865722949 5323.826929159884 0.8413459534001579 0.9657370732145673 0.9804928082565185 1.0212797786324628 0.9261688119810896 0.8889489762724342 0.8750175297707316 0.9627749376713973 0.9480341740784965 1.0 12.378247956493928 KPEKPLFSSAS(ph)PQDSSPR ddPTM_A459_Selumetinib_30min_R2 2 KPEKPLFSSASPQDSSPR 18 2 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 KPEKPLFSS(0.002)AS(0.454)PQDS(0.135)S(0.409)PR;KPEKPLFS(0.002)S(0.068)AS(0.796)PQDS(0.068)S(0.068)PR 93.255 0.0018328 41719000.0 167316.0 155091.0 177938.0 168979.0 175172.0 151846.0 132592.0 141247.0 121490.0 159514.0 True False 158017.24653901637 166985.98100383618 166489.6628042457 145963.76869496593 153165.32730245055 172761.40817925314 138757.79072606357 141658.0053853005 145791.39471422214 154908.41635285484 1.0200688268549603 1.0779658390120697 1.0747618930207816 0.9422584784708241 0.9887476155818814 1.1152486885265953 0.8957408124939906 0.9144629370080695 0.9411457307918913 1.0 17.241056003978557 -7.278394424341743 24.99808847846512 0.930709278316376 1.033676724222479 0.45884569913591877 0.05221251358438054 775.2715418230318 1143036.060139154 0.02251190543105132 0.015220192796537019 5.267512509462869e-08 7.278394424341743 0.10296744590610296 KPEKPLFSSASPQDS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 KPEKPLFSSASPQDSSPR 18 2 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 KPEKPLFS(0.009)S(0.092)AS(0.146)PQDS(0.61)S(0.143)PR 84.37100000000002 0.0090852 27847000.0 2282.2 2472.6 2330.8 2810.0 2254.6 2128.0 2051.5 1958.9 1397.6 1751.6 True False 2335.370819611832 2183.106842519445 2014.2901621679528 2319.2862502328285 2050.6718280819605 2106.594252069407 1896.7537033278747 1906.9436085960408 2371.6251233346984 1976.4349220288339 1.1816077491762522 1.104568037220502 1.019153294508812 1.1734695761457472 1.037561017175775 1.0658556113281803 0.9596843701693121 0.964840070038097 1.1999510314765118 1.0 10.948684737056157 -6.385791438109386 9.104400960851073 1.0332795650681625 1.111373824148918 0.21407030692847362 0.07575680367438577 0.5687655582026839 39.534794433531175 0.0234863560855201 0.026624682281311894 4.113472155696697e-07 6.385791438109386 0.0780942590807554 KPENEVAQNGGAETSHTEPVS(ph)PIPK ddPTM_A459_Selumetinib_30min_R2 3 KPENEVAQNGGAETSHTEPVSPIPK 25 1 O95104-2;O95104-3;O95104 O95104-2 SCAF4 Splicing factor, arginine/serine-rich 15 1 KPENEVAQNGGAET(0.003)S(0.01)HT(0.159)EPVS(0.828)PIPK;KPENEVAQNGGAETSHT(0.002)EPVS(0.997)PIPK;KPENEVAQNGGAET(0.02)S(0.02)HT(0.097)EPVS(0.863)PIPK 87.868 3.7781e-05 58542600.0 149574.0 80153.2 100538.0 129842.0 130368.0 146006.0 279902.0 305433.0 273880.0 100703.1 True False 141261.2758721631 86300.69270684064 94069.4945374978 112157.29561005683 113990.00633529255 166117.00118949497 292917.9976152913 306321.7594628447 328663.6528465814 97795.53984492389 1.4444551980199056 0.8824604153081947 0.9618996396631734 1.146854915754917 1.1655951438690202 1.6986153095827237 2.995208146299683 3.1322671764845773 3.360722312773662 1.0 16.57748104932471 -7.070161801576601 3.0190986264159534 2.798520911031402 1.1053815300285834 0.553208271388786 0.6264988361121214 0.17222850214670823 3.072881445989504 0.24374034861180177 0.18852336394901195 8.508209956617969e-08 7.070161801576601 -1.6931393810028188 KPES(ph)PYGNLCDAPDSPRPVK ddPTM_A459_Selumetinib_30min_R1 1 KPESPYGNLCDAPDSPRPVK 20 2 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 KPES(0.784)PY(0.215)GNLCDAPDS(0.001)PRPVK 64.962 0.019693 9518300.0 889.16 836.81 1035.9 1057.4 975.84 855.68 776.74 872.04 269.26 596.29 True False 909.8756979958184 738.8358961775848 895.2304697913941 872.744939856297 887.5754442985453 847.0726360952776 718.1498764430381 848.9106664148718 456.9145540276911 672.8296298564592 1.3523121717899529 1.0981024963707489 1.3305455498182825 1.297126198265804 1.3191681889632296 1.2589704711369374 1.0673576854756641 1.2617022627198768 0.6790939842009764 1.0 9.394097429710419 -8.248603207667278 24.98555950727855 0.8395469986586767 1.2442375376650776 0.6688628415151567 0.11497625110296951 370.9752069960903 722105.3788116106 0.07596113550507044 0.028305347512343634 5.641528576258527e-09 8.248603207667278 0.40469053900640095 KPES(ph)PYGNLCDAPDSPRPVK ddPTM_A459_Selumetinib_30min_R2 1 KPESPYGNLCDAPDSPRPVK 20 2 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 KPES(0.893)PY(0.107)GNLCDAPDSPRPVK 57.525 0.014968 9210600.0 97850.0 88100.0 98520.0 106080.0 99661.0 85584.0 82437.0 73366.0 60543.0 92549.0 True False 92411.88872458547 94856.98671385128 92181.33046046548 91631.72100179293 87140.69419935562 97372.41914580046 86270.48384581646 73579.48291360485 72653.2917127596 89876.86989881996 1.0282054640823532 1.0554104389776562 1.0256401960175048 1.0195250580594153 0.9695563975186873 1.0833979783165426 0.9598741471853277 0.8186698423792228 0.8083647304868313 1.0 16.455662260853167 -7.562202754436808 4.822184097653143 0.8620734122024255 1.0278484444492528 0.6024532095613233 0.05591652051339757 0.1186295494535335 6.4677184340212355 0.025844654724610297 0.014819249833063913 2.740294541136219e-08 7.562202754436808 0.16577503224682733 KPESAAGS(ph)QSPALPPR ddPTM_A459_Selumetinib_30min_R1 1 KPESAAGSQSPALPPR 16 1 Q02297-2;Q02297-6;Q02297;Q02297-7;Q02297-12;Q02297-3;A0A494C0K4;A0A494C114;Q02297-8;Q02297-4 Q02297-2 NRG1 Pro-neuregulin-1, membrane-bound isoform;Neuregulin-1 1 KPESAAGS(0.963)QS(0.037)PALPPR 107.18 0.0017265999999999998 3378300.0 1156.3 1388.5 1370.1 1673.9 1071.3 1179.0 1126.4 1062.1 736.03 672.78 True False 1183.2395402318643 1225.9337745038629 1184.04794542059 1381.5847879945659 974.4011041533767 1167.1403304463493 1041.4347411301571 1033.9296578129854 1248.989152495734 759.1378664321534 1.558662256953315 1.6149026793586096 1.5597271559979706 1.8199392351323878 1.2835627719809732 1.5374550289946054 1.3718650948407585 1.361978770302049 1.645273154882678 1.0 9.568218105923917 -6.273440327194946 24.997242701036587 1.393585168505862 1.631023137282785 0.3660252644825115 0.17285795801738868 897.7982893346265 1870054.859553634 0.05048130610951722 0.057682680796437034 5.327944261597836e-07 6.273440327194946 0.23743796877692303 KPESAAGSQS(ph)PALPPR ddPTM_A459_Selumetinib_30min_R1 1 KPESAAGSQSPALPPR 16 1 Q02297-2;Q02297-6;Q02297;Q02297-7;Q02297-12;Q02297-3;A0A494C0K4;A0A494C114;Q02297-8;Q02297-4 Q02297-2 NRG1 Pro-neuregulin-1, membrane-bound isoform;Neuregulin-1 1 KPESAAGS(0.151)QS(0.849)PALPPR 117.27 0.0016194000000000002 0.0 1584.1 1363.5 1956.8 1740.6 1206.9 1292.8 1355.9 1392.2 1218.1 1244.6 True False 1621.0064478779705 1203.8607861260475 1691.077307933004 1436.6368851086347 1097.736108095502 1279.7956057684821 1253.6233713586469 1355.2743334970687 2067.0267334959926 1404.3565334306275 1.1542698803971814 0.8572330155969726 1.2041652298949768 1.0229858664160953 0.7816648279578272 0.9113039141436099 0.892667454108849 0.9650500433720641 1.471867495390621 1.0 10.45569353349088 -10.356910367780525 5.138929546470963 0.9999999874516105 1.0123145156863143 0.0 0.19294115227934705 2.7557764650886357e-08 6.470614984399091e-09 0.1859586664109751 0.04510155535237189 4.39632339953021e-11 10.356910367780525 0.012314528234703803 KPESAAGSQS(ph)PALPPR ddPTM_A459_Selumetinib_30min_R2 1 KPESAAGSQSPALPPR 16 1 Q02297-2;Q02297-6;Q02297;Q02297-7;Q02297-12;Q02297-3;A0A494C0K4;A0A494C114;Q02297-8;Q02297-4 Q02297-2 NRG1 Pro-neuregulin-1, membrane-bound isoform;Neuregulin-1 1 KPESAAGS(0.245)QS(0.755)PALPPR 88.28200000000002 0.007220399999999998 5735700.0 11456.0 13017.0 15634.0 15038.0 16130.0 9433.0 12083.0 13955.0 10703.0 12825.0 True False 10819.32138200154 14015.362043748057 14628.12546101215 12989.79845800306 14103.605195970404 10732.310125751725 12644.883442010283 13995.606739625393 12843.89906680648 12454.708926648216 0.8686932344803672 1.1253062698045597 1.1745056064468653 1.0429628291199935 1.1323913934105834 0.8617070209315586 1.0152692862179353 1.1237200983220297 1.0312484332191456 1.0 13.604403684950912 KPFVALGSGEES(ph)PLEGW ddPTM_A459_Selumetinib_30min_R1 1 KPFVALGSGEESPLEGW 17 1 E7EUN9;Q9NX74 E7EUN9 DUS2 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like 1 KPFVALGSGEES(1)PLEGW 76.32600000000002 0.037923 8458000.0 3073.4 3503.2 4298.2 3998.7 3743.7 3368.1 3312.8 2940.5 1965.6 2620.0 True False 3145.00424020463 3093.0437154065025 3714.528048322588 3300.4021098953776 3405.08299600392 3334.2199719901173 3062.912828849418 2862.508387909878 3335.4796382560726 2956.302520961147 1.0638303143556949 1.046254127740925 1.256477651385599 1.1163952560654578 1.1518046518787484 1.127834498786715 1.0360620427484566 0.9682731613607748 1.1282605939704873 1.0 11.52957819391568 -7.267698015288209 5.975407554695718 1.029971765330805 1.1301652330884138 0.3323225965936223 0.06513881179009298 0.18812985220491435 29.71333964586904 0.02693059078289175 0.01911049930919938 5.3988589925474054e-08 7.267698015288209 0.10019346775760885 KPGPPLS(ph)PEIR ddPTM_A459_Selumetinib_30min_R1 2 KPGPPLSPEIR 11 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPGPPLS(1)PEIR;KPGPPLS(1)PEIR 68.972 0.036162 12776300.0 4868.299999999999 6128.9 5847.6 5995.4 5721.9 4672.1 6277.700000000001 5985.700000000001 3016.1000000000004 5709.8 True False 4981.721917937203 5411.325538751694 5053.528038567577 4948.415937596408 5204.355155283497 4625.102915927387 5804.168034794735 5826.939791706223 5118.101412771741 6442.708448161818 0.7732341076769582 0.8399147008267323 0.7843794390555434 0.768064545743685 0.8077899531164354 0.7178817655867983 0.9008894444774594 0.9044239450830216 0.7944021453014837 1.0 12.653451594630475 -9.19460334643579 0.38865620920806654 1.0236752366731223 0.782638381743881 0.5693576761852535 0.05209724659608522 2.284108210615564 0.588848869452304 0.15831362149868772 0.04111243401411985 6.38846696767536e-10 9.19460334643579 -0.24103685492924132 KPGPPLS(ph)PEIR ddPTM_A459_Selumetinib_30min_R2 1 KPGPPLSPEIR 11 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPGPPLS(1)PEIR 95.195 0.011019 15201000.0 40524.0 34680.0 39382.0 43775.0 57862.0 39946.0 37231.0 52950.0 45413.0 41602.0 True False 38271.83831042515 37339.844486224385 36848.20499587953 37812.76948391302 50592.85826715684 45448.198906315905 38962.315271826934 53104.07573365564 54496.868945238064 40400.84216502291 0.9473029832917457 0.9242343101092931 0.9120652694656183 0.9359401303928631 1.2522723675042022 1.1249319685138335 0.9643936409216395 1.3144299199691085 1.3489042808226115 1.0 15.302097746156191 -6.247149954629041 23.398643477475336 1.170927595971365 0.928209054636339 0.5034124295892596 0.1155744264125687 300.74213004365134 492457.6973115771 0.03563004436076538 0.04573304666454709 5.660438098214464e-07 6.247149954629041 -0.24271854133502602 KPGPSGPS(ph)ESPK ddPTM_A459_Selumetinib_30min_R1 1 KPGPSGPSESPK 12 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPGPS(0.049)GPS(0.507)ES(0.445)PK 115.83 0.0092684 58251000.0 10008.0 12122.0 12895.0 13504.0 7923.4 10426.0 9070.4 8293.3 7868.5 10584.0 True False 10241.16692782194 10702.750604635086 11143.929827164802 11145.77990147478 7206.729868989885 10321.123906050585 8386.212425379066 8073.334743565035 13352.269807497909 11942.559496890386 0.8575353491425807 0.8961856633347213 0.933127428007913 0.9332823423971157 0.6034493586459737 0.8642304782938706 0.7022123211998798 0.6760137762484815 1.1180408865431724 1.0 13.543824443769546 -3.606527667496544 15.079992649086524 0.8433537272101812 89.29094983120598 0.0 0.15001446457306133 0.0 0.0 0.0337607606603843 0.0 0.0002474413819412472 3.606527667496544 88.44759610399579 KPGPSGPSES(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KPGPSGPSESPK 12 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPGPS(0.014)GPS(0.042)ES(0.944)PK 115.1 0.0095875 56075000.0 4334.0 5042.3 5255.5 5331.3 3271.7 3714.4 3862.8 3168.5 3027.3 3673.2 True False 4434.973767504023 4451.945171898326 4541.831966395087 4400.288535895474 2975.7753126655502 3677.0365084053615 3571.4258860418795 3084.4610872615026 5137.10699475611 4144.690999997894 1.0700372518738492 1.0741319852072417 1.0958191977151963 1.0616686589899487 0.7179727783487507 0.8871678270846318 0.8616868871632877 0.7441956679673032 1.2394426978413398 1.0 12.017048832851653 -6.042680312276476 23.039201635309134 0.8920039122604537 1.0792988061538973 0.26081477113653473 0.13632273575591122 232.51880797895083 125515.10441538533 0.03892405347407103 0.05025811294270243 9.063995635288021e-07 6.042680312276476 0.18729489389344356 KPGPSGPSES(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 KPGPSGPSESPK 12 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPGPS(0.001)GPS(0.11)ES(0.889)PK;KPGPS(0.001)GPS(0.37)ES(0.629)PK 95.073 0.0094317 152810000.0 397150.0 368750.0 326750.0 331340.0 277071.0 213328.0 329350.0 264228.0 186709.0 273220.0 True False 375077.992917416 397031.93928187055 305727.2607385015 286210.92040661816 242262.86393383227 242711.99560122556 344665.4275946441 264996.8597346998 224056.01708533755 265331.42868918687 1.4136206734739587 1.4963622713046918 1.1522466910493099 1.0786921165750396 0.9130575489329708 0.9147502683730013 1.2989996296231843 0.9987390526778531 0.8444382868333327 1.0 18.017436048339377 -5.440210467496849 2.3794082406079355 1.0100380031233585 1.4643175477113064 0.6890339259305548 0.11853640564667525 0.17767166735818524 1.9398322911762063 0.03502238532325981 0.09156226085874307 3.6290214275842255e-06 5.440210467496849 0.45427954458794795 KPIDSLRDS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 KPIDSLRDSR 10 2 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 KPIDSLRDS(1)R 93.243 0.028817 141090000.0 5798.8 7246.2 4258.7 3671.8 6272.2 4320.0 8078.0 8477.9 3853.5 8921.7 True False 5933.900757499385 6397.81153533301 3680.3919313646193 3030.5890582223838 5704.880617446847 4276.544722246169 7468.6699563648845 8253.038551899728 6539.10805149561 10066.887099717209 0.5894474328281754 0.6355302758399598 0.3655938419601434 0.30104530111473254 0.5666975859505868 0.42481302113404074 0.7419046108677119 0.8198203148748501 0.6495660462586594 1.0 13.29733001919193 -7.3491512081868136 4.5130604402728745 0.7967518183205708 0.4781816129767056 0.6161331362362705 0.1250728329956361 0.1691268643626564 6.074522655425434 0.05596031085270336 0.03702128960830714 4.47557451095233e-08 7.3491512081868136 -0.31857020534386526 KPIETGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 KPIETGSPK 9 1 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 KPIET(0.008)GS(0.992)PK;KPIET(0.037)GS(0.963)PK 132.14 0.0061664 783750000.0 8556.9 11522.8 11811.2 10305.0 6710.4 9705.400000000001 7124.200000000001 8731.0 10829.5 8637.8 True False 8756.259121171017 10173.705219195606 10207.303914277545 8505.425198807583 6103.445504817344 9607.772487798135 6586.815858273672 8499.425517715063 18376.870544614434 9746.545769297021 0.8983961424317581 1.0438267525756866 1.0472739938729858 0.8726604686555578 0.6262162666946118 0.9857617986121768 0.6758102833747583 0.8720448986644518 1.8854752216425372 1.0 13.250675294860361 -8.224283426252939 24.06740683371007 1.4427375652064667 0.8772505644819655 0.4749754006671695 0.23760371000057204 251.4124465380009 162850.39495794108 0.15152477891963545 0.057266589361327565 5.966457806677078e-09 8.224283426252939 -0.5654870007245012 KPIETGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 KPIETGSPK 9 1 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 KPIET(0.026)GS(0.974)PK;KPIET(0.011)GS(0.989)PK;KPIET(0.042)GS(0.958)PK;KPIET(0.041)GS(0.959)PK 98.407 0.011899 725014000.0 534053.0 467937.0 349916.0 353943.0 344509.0 246555.0 546947.0 683740.0 350007.0 596736.0 True False 504372.4722435466 503826.26324539643 327402.78551973414 305735.3528142687 301228.69947046344 280515.7132465512 572381.1192549191 685729.5702007491 420018.1800126828 579506.6811736721 0.8703479849827503 0.869405443652521 0.564968094684684 0.5275786505085056 0.5198019440610873 0.4840594981207535 0.987704090133488 1.1832988168694523 0.7247857421799211 1.0 19.144465768697998 -7.278687506333028 23.414181801364222 0.9892221805562236 0.6359199655116693 0.4973725371143848 0.16446879231156736 322.4682447791172 437744.7891452755 0.07361143558394478 0.049798872888888845 5.263958947723878e-08 7.278687506333028 -0.3533022150445543 KPLAAPGDGEGLGQTAQPS(ph)PPAR ddPTM_A459_Selumetinib_30min_R1 1 KPLAAPGDGEGLGQTAQPSPPAR 23 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 KPLAAPGDGEGLGQT(0.031)AQPS(0.969)PPAR 59.732 0.0062001 12147000.0 2052.9 2357.5 2680.6 2634.2 2071.4 1919.9 2047.4 1983.6 1532.1 2039.7 True False 2100.728575751962 2081.482804027985 2316.589243481814 2174.1864200581194 1884.0422357353739 1900.5875491297265 1892.9629696288032 1930.9884843591353 2599.8617998433697 2301.5153633604787 0.9127588758237335 0.9043966584645254 1.0065495457303077 0.9446760402605159 0.8186094543311908 0.8257983324320064 0.8224854805508917 0.8390074274975374 1.1296304344661297 1.0 11.168368357712696 -8.257761880479906 24.998481636215935 1.0648152236116861 0.8848453631858931 0.5549398895060085 0.06466737221070508 241.45982122481965 1641398.4334224002 0.05304143916528545 0.018254631095421463 5.523802210710139e-09 8.257761880479906 -0.179969860425793 KPLAAPGDGEGLGQTAQPS(ph)PPAR ddPTM_A459_Selumetinib_30min_R2 2 KPLAAPGDGEGLGQTAQPSPPAR 23 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 KPLAAPGDGEGLGQTAQPS(1)PPAR;KPLAAPGDGEGLGQT(0.001)AQPS(0.999)PPAR 175.26 2.9735000000000005e-14 22887000.0 47355.0 44172.0 43229.0 46824.0 48508.0 39599.0 39366.0 39482.0 32106.0 44520.0 True False 44723.19867708476 47559.85036463389 40447.693204176445 40446.49042409464 42413.99137297784 45053.40280606831 41196.59700224918 39596.886083403035 38528.09711659245 43234.59192314844 1.0344309194957222 1.1000416159628337 0.9355400711558505 0.9355122513007691 0.981019815067776 1.0420684179499808 0.9528619369295335 0.9158612195019303 0.8911405289791562 1.0 15.399898451798455 -5.265096045900016 24.99783337666973 0.9567620112388561 1.0672362711838412 0.5097563743293834 0.04334018943793965 246.4712850970569 1684945.168233856 0.012132837648318625 0.026871069810758007 5.43130202869914e-06 5.265096045900016 0.11047425994498516 KPLFHGDSEIDQLFR ddPTM_A459_Selumetinib_30min_R1 2 KPLFHGDSEIDQLFR 15 1 A0A087WZZ9;P06493;A0A024QZP7;P06493-2 A0A087WZZ9 CDK1;CDC2 Cyclin-dependent kinase 1 0 ; 148.41 0.00020598 15708800.0 7647.6 10398.6 10206.099999999999 10973.6 9187.2 7809.200000000001 8364.0 8107.4 4724.0 6569.1 False True 7825.77420036081 9181.127077822015 8820.167678094358 9057.266759983977 8356.219382131902 7730.646538186288 7733.096746104966 7892.365415453338 8016.282972691127 7412.307973452627 1.055781037213918 1.2386327053199164 1.1899354033431984 1.2219226174118523 1.1273437925218321 1.0429472933226465 1.0432778527013788 1.0647649077345476 1.081482717852746 1.0 12.855707109705405 -6.588012336568089 3.664420854510176 1.0505881710159684 1.1817847565180337 0.6030990724807449 0.04980416858044072 0.15552047220945986 4.2304009642111735 0.016571905548920622 0.016847187143021417 2.582186839999157e-07 6.588012336568089 0.13119658550206537 KPLS(ph)PVRDNIQLTPEAEEDIFNKPECGR ddPTM_A459_Selumetinib_30min_R2 1 KPLSPVRDNIQLTPEAEEDIFNKPECGR 28 3 Q9UQ84;H0YAZ2 Q9UQ84 EXO1 Exonuclease 1 1 KPLS(0.983)PVRDNIQLT(0.017)PEAEEDIFNKPECGR 45.072 0.037295 5237000.0 8497.2 9875.0 8729.8 7847.6 8400.5 6547.0 6961.2 7895.9 4637.6 7437.6 True False 8024.959640986689 10632.3807468704 8168.1341722875695 6778.743342134913 7345.154088577149 7448.789822251303 7284.90959335612 7918.875761763383 5565.249585370622 7222.85716279445 1.1110505801393853 1.472046380986003 1.1308730033264844 0.9385127227841076 1.0169319319247598 1.0312802336201041 1.0085911197138588 1.0963633342431556 0.7705052806578669 1.0 12.818353924989143 -5.517263541477207 5.7097132161903605 0.9913906200702248 1.2959017737145802 0.5434706193426763 0.11429919132841877 0.10720926087604805 12.750101007031933 0.028780349959884412 0.05528078687914033 3.0390402952940227e-06 5.517263541477207 0.3045111536443553 KPLSLAGDEETECQS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 KPLSLAGDEETECQSSPK 18 1 F5H1K3;Q86TN4-2;Q86TN4;Q86TN4-4 F5H1K3 TRPT1 tRNA 2-phosphotransferase 1 1 KPLSLAGDEET(0.001)ECQS(0.5)S(0.5)PK 92.211 0.0026065000000000003 25764000.0 9248.9 11571.0 12942.0 13209.0 9341.2 10648.0 9377.7 10845.0 7557.1 11100.0 True False 9464.381374773408 10216.26194078804 11184.547485317335 10902.296113638948 8496.290109322808 10540.890787610453 8670.332538970415 10557.355370475307 12823.846751254048 12524.79312315601 0.7556517127037834 0.8156830887609691 0.8929925927989333 0.8704571809240211 0.6783577202257137 0.8416019876705435 0.692253552910234 0.842916546937348 1.0238769315514795 1.0 13.6124991536157 -8.187310802287257 4.255418503017186 1.0132785329180174 0.7962030997363481 0.6252096263997071 0.06672763879577426 0.14281667357466873 4.756310507354647 0.05247719640459674 0.017644320399507526 6.496645923098387e-09 8.187310802287257 -0.21707543318166933 KPLSLAGDEETECQS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 KPLSLAGDEETECQSSPK 18 1 F5H1K3;Q86TN4-2;Q86TN4;Q86TN4-4 F5H1K3 TRPT1 tRNA 2-phosphotransferase 1 1 KPLSLAGDEETECQS(0.5)S(0.5)PK;KPLSLAGDEET(0.009)ECQS(0.496)S(0.496)PK 120.32 0.00049079 29627000.0 190616.0 161427.0 169168.0 146149.0 146433.0 115083.0 156390.0 150313.0 96355.0 154264.0 True False 180022.32581630637 173807.93183038468 158283.9150561923 126243.25407891291 128036.7774123704 130934.63863054021 163662.4448809061 150750.38594434335 115628.69238364384 149809.99749399335 1.201670975420211 1.1601891378267564 1.0565644329747665 0.8426891141492386 0.8546611010890915 0.8740046780642263 1.09246677537304 1.006277207570127 0.7718356205718513 1.0 17.19277437896597 -5.475556448944361 3.1544704515400466 0.9234025743661919 1.1797668686505665 0.5775055337056668 0.08958977439176594 0.18941336795490768 3.731969103877677 0.026165166659764445 0.058315097635057295 3.3453653247132976e-06 5.475556448944361 0.25636429428437457 KPLSLAGDEETECQSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KPLSLAGDEETECQSSPK 18 1 F5H1K3;Q86TN4-2;Q86TN4;Q86TN4-4 F5H1K3 TRPT1 tRNA 2-phosphotransferase 1 1 KPLSLAGDEETECQS(0.246)S(0.754)PK 144.3 0.00014682 24779000.0 6822.7 7588.5 8685.3 8274.1 6021.8 6182.9 6695.2 6344.5 4737.0 6133.0 True False 6981.655635336805 6700.034892202064 7505.883964937925 6829.1837590930445 5477.129253235136 6120.70563962403 6190.175673663553 6176.223250159574 8038.343023208697 6920.230290478906 1.0088761995308755 0.9681809146467576 1.084629217508091 0.9868434246312401 0.7914663274675644 0.8844656005227326 0.8945042887055671 0.8924881096308366 1.161571607561692 1.0 12.75660433313156 -6.0119446782332195 24.796411299599825 0.9237843427091593 1.0187260562564964 0.12698694853383197 0.09499340178942119 941.1705638396928 1953817.6180860982 0.02785888658993366 0.038104540912447 9.728711432024717e-07 6.0119446782332195 0.09494171354733705 KPLSLAGDEETECQSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 KPLSLAGDEETECQSSPK 18 1 F5H1K3;Q86TN4-2;Q86TN4;Q86TN4-4 F5H1K3 TRPT1 tRNA 2-phosphotransferase 1 1 KPLSLAGDEETECQS(0.321)S(0.679)PK;KPLSLAGDEETECQS(0.247)S(0.753)PK 135.98 0.00018236 36168000.0 241700.0 219388.0 223095.0 195145.0 185473.0 147039.0 198649.0 185231.0 115586.0 162649.0 True False 228267.28160176112 236214.35415639577 208741.3105874706 168565.91435609802 162172.22359034207 167292.28756285444 207886.57211552616 185769.99154335714 138706.4297426791 157952.90075714642 1.4451604276183792 1.4954733532850837 1.321541482219511 1.0671910015458923 1.0267125378069688 1.0591276688236793 1.3161301319508723 1.1761100344018354 0.8781505694279151 1.0 17.269134906422025 -5.589481925504968 3.181484635267 1.089237515384502 1.4651163279582913 0.6874275497493558 0.10937723291672515 0.14875295720696757 3.0286737612730823 0.03240102735411178 0.06392000802799785 2.5734638647782405e-06 5.589481925504968 0.3758788125737893 KPLTS(ph)SSAAPQRPISTQR ddPTM_A459_Selumetinib_30min_R1 1 KPLTSSSAAPQRPISTQR 18 2 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 1 KPLT(0.019)S(0.826)S(0.113)S(0.043)AAPQRPISTQR 81.017 0.012186 25143000.0 746.19 817.67 1121.3 1376.4 1165.5 797.71 1550.3 1967.0 1701.5 1026.4 True False 763.5747751670115 721.9368162755295 969.0336188600153 1136.0375782279234 1060.0807307857383 789.6857616627292 1433.3596228463095 1914.8287702835337 2887.321227356893 1158.148437982642 0.6593064844926689 0.6233543064074397 0.8367093431891662 0.9809084405508217 0.9153237150086512 0.6818519420863431 1.2376303208102175 1.6533534972589001 2.4930493645410996 1.0 10.177604457693189 -7.610077361650951 2.587367657354677 1.8251802758775961 0.795509249522351 0.5782564470548228 0.35504360832830995 0.18302849523119882 2.463427521035727 0.193750266038447 0.09829783017162884 2.454271692948854e-08 7.610077361650951 -1.029671026355245 KPNAGGS(ph)PAPVR ddPTM_A459_Selumetinib_30min_R1 1 KPNAGGSPAPVR 12 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 KPNAGGS(1)PAPVR 99.834 0.025145 11672000.0 1832.9 3472.5 1834.4 2178.1 1934.3 1595.1 2412.2 1764.7 902.94 2288.1 True False 1875.6030037974454 3065.938085678548 1585.2985556379317 1797.7357230007556 1759.3429065284013 1579.054742234921 2230.2458119266385 1717.894423446544 1532.2232318716617 2581.799922981374 0.7264710898401311 1.1875196286078231 0.6140284309123704 0.6963110142651147 0.6814404520148767 0.6116100353785288 0.8638337123161841 0.665386348552826 0.593470941815779 1.0 11.334161487744536 -5.283253744363546 24.995244845419702 0.703458009389822 0.9569954392475026 0.2684342250752849 0.15825821009250243 797.1803216775145 913420.7436852809 0.038269376848914446 0.07977047299287676 5.208902826619381e-06 5.283253744363546 0.2535374298576807 KPNAGGS(ph)PAPVR ddPTM_A459_Selumetinib_30min_R2 1 KPNAGGSPAPVR 12 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 KPNAGGS(1)PAPVR 67.846 0.036482 33169000.0 61704.0 37885.0 66361.0 58770.0 46833.0 45745.0 53708.0 52925.0 51229.0 38451.0 True False 58274.73870068289 40790.6576805251 62091.405508393764 50765.4246160952 40949.419847667814 52045.95851823519 56205.528420383016 53079.00298779458 61476.23145785564 37340.81972230412 1.5606175529637525 1.0923878475051354 1.6628292032728413 1.3595155380526476 1.0966395529664346 1.3938086765445996 1.5052033897052017 1.421473962878481 1.6463546305368102 1.0 15.18846597814523 -6.995842917825889 24.992572023961515 1.4313987405441053 1.3460575247060662 0.0 0.2260476908496946 539.2109422533214 3241730.7938621067 0.0768284386637525 0.06748447883341886 1.0096179938973377e-07 6.995842917825889 -0.08534121583803911 KPNAGGS(ph)PAPVRR ddPTM_A459_Selumetinib_30min_R2 1 KPNAGGSPAPVRR 13 2 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 KPNAGGS(1)PAPVRR 60.901 0.03575 23088000.0 115550.0 108300.0 116630.0 124320.0 123900.0 92609.0 108080.0 125630.0 106330.0 81713.0 True False 109128.19358329938 116606.26176061403 109126.15277714287 107387.40153603804 108334.57431994626 105365.04912919976 113105.9341564571 125995.56250083396 127598.97110843062 79353.73337412917 1.37521183872714 1.4694489698531297 1.3751861208929594 1.3532747228128323 1.3652108062664308 1.3277894391236138 1.425338536035808 1.587771074447153 1.6079769115189522 1.0 16.276010479026276 -7.518084916685278 24.682758975793842 1.460035339942192 1.3797755894828976 0.0 0.1617206960563184 628.1573337321122 3234356.5515945144 0.06997550090414249 0.04186259042967664 3.0332980318322146e-08 7.518084916685278 -0.08025975045929434 KPNIFYSGPAS(ph)PARPR ddPTM_A459_Selumetinib_30min_R1 3 KPNIFYSGPASPARPR 16 2 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 KPNIFYSGPAS(1)PARPR;KPNIFYSGPAS(1)PARPR;KPNIFYS(0.029)GPAS(0.971)PARPR 137.27 0.0014058 278661000.0 9354.6 10481.100000000002 12296.400000000001 12366.4 10661.0 10459.5 10112.9 9921.300000000001 5944.639999999999 8639.699999999999 True False 9572.543979117017 9253.967939468806 10626.616419290376 10206.840386078025 9696.71443235242 10354.286926466153 9350.075811057493 9658.154895075764 10087.619900672858 9748.689652804596 0.9819313487288106 0.9492524912624064 1.0900558739433468 1.0469961348232708 0.9946684916329014 1.0621208895994891 0.9591110337959701 0.9907131357184208 1.0347667491672334 1.0 13.250992600094191 -5.197800340258727 24.99983402331126 1.0210328963862492 0.9655918359156377 0.2719766487217128 0.03706770438814081 297.9210104992513 117032.763650759 0.00967702790062869 0.025603008563499622 6.341611894216817e-06 5.197800340258727 -0.05544106047061148 KPNIFYSGPAS(ph)PARPR ddPTM_A459_Selumetinib_30min_R2 2 KPNIFYSGPASPARPR 16 2 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 KPNIFYS(0.091)GPAS(0.909)PARPR;KPNIFYSGPAS(1)PARPR 74.812 0.012456 126717000.0 103015.0 96403.0 126981.0 120353.0 124470.0 105334.0 97687.0 95227.0 78927.0 118676.0 True False 97289.83870171873 103796.80011549855 118811.18070645959 103960.7137794945 108832.96582408162 119842.80237315079 102229.6390631182 95504.09480432142 94714.60540463764 115249.51552272169 0.8441670080820238 0.9006267804660297 1.0309039492928342 0.9020490308178208 0.9443247143422913 1.0398551510572165 0.8870287966023025 0.8286724188917963 0.8218221566924023 1.0 16.814401160410853 -10.41180410282637 4.440611222266529 1.0000008764439576 0.9156414959989035 0.11713667834018493 0.07227749781546208 17729472.699115496 8314248.634498148 157.19276583355355 0.01876834116658636 3.8743236459577226e-11 10.41180410282637 -0.08435938044505409 KPPAPPS(ph)PVQS(ph)QSPSTNWSPAVPVK ddPTM_A459_Selumetinib_30min_R2 2 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.878)PVQS(0.41)QS(0.428)PS(0.141)T(0.13)NWS(0.013)PAVPVK;KPPAPPS(0.573)PVQS(0.489)QS(0.338)PS(0.31)T(0.282)NWS(0.007)PAVPVK 69.72 0.0031632 46855000.0 209309.0 168506.0 208202.0 213819.0 223820.0 193054.0 203729.0 213087.0 188534.0 198240.0 True False 197676.44371031408 181429.86836781222 194806.50999319775 184696.4833416516 195701.73062381265 219645.43613027368 213202.802181355 213707.04789154802 226246.06808009872 192516.29611062343 1.0268036924870274 0.942413042600608 1.0118962078995033 0.9593810346087355 1.0165463110268795 1.1409186680179082 1.1074532727288953 1.1100725092318833 1.1752047626663955 1.0 17.5546210465971 -6.6395162814032505 4.707570583087502 1.113285756988003 0.9844460902756172 0.5984122765297455 0.04752365772540431 0.13187610079965087 4.857967304869351 0.014930151636990139 0.014862587815602285 2.2934206500634993e-07 6.6395162814032505 -0.12883966671238578 KPPAPPS(ph)PVQS(ph)QSPSTNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R1 2 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.843)PVQS(0.438)QS(0.438)PS(0.141)T(0.141)NWS(0.001)PAVPVKK;KPPAPPS(0.988)PVQS(0.468)QS(0.468)PS(0.038)T(0.038)NWSPAVPVKK 63.979 0.005256899999999999 69006000.0 7594.7 7980.099999999999 11503.6 10961.6 9474.1 7996.1 8296.1 8344.3 4054.7 6719.5 True False 7771.641733286293 7045.7861821521565 9941.474304751699 9047.36233471608 8617.169327788213 7915.666493877912 7670.318497771572 8122.982057893692 6880.5297564290295 7582.013278472688 1.0250103037081206 0.9292764234740896 1.3111918879089983 1.1932664850909585 1.136527860252448 1.0440058864513668 1.0116466716761898 1.0713489622811603 0.907480573262071 1.0 12.888365267782346 -6.9277867921651 3.331318709352735 1.0050085190301454 1.123180916567915 0.2430287590512149 0.10091089535078013 0.4125996614411076 9.235500396821863 0.041440007483034905 0.03537803372951023 1.1809002317549812e-07 6.9277867921651 0.11817239753776954 KPPAPPS(ph)PVQS(ph)QSPSTNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R2 1 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.874)PVQS(0.553)QS(0.553)PS(0.019)T(0.002)NWSPAVPVKK 80.844 0.00038095 16494000.0 41725.0 45939.0 46633.0 48745.0 39811.0 32730.0 32006.0 28578.0 27245.0 43637.0 True False 39406.091538409084 49462.37358283338 43632.683550171445 42105.84691018478 34809.58626514431 37238.26040664199 33494.342418685854 28661.157248657422 32694.761288904287 42377.086427457936 0.9298914781662805 1.1671961843696876 1.0296291517082674 0.9935993825876286 0.8214247179246774 0.8787357401360589 0.7903880432181725 0.6763361916756653 0.7715198010337951 1.0 15.37099678035171 -6.212200158068497 1.6805713109632112 0.7975061621000155 1.0592053899514922 0.5234475038029989 0.09582405011292627 0.26235962103312294 1.4672129957939162 0.03333051405838402 0.04647137542375374 6.134791991024174e-07 6.212200158068497 0.2616992278514767 KPPAPPS(ph)PVQSQSPS(ph)TNWSPAVPVK ddPTM_A459_Selumetinib_30min_R1 1 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.867)PVQS(0.233)QS(0.088)PS(0.437)T(0.369)NWS(0.005)PAVPVK 93.611 3.980300000000001e-05 38764000.0 4576.7 7180.8 5351.0 5808.8 5686.3 5188.7 5906.5 4745.9 3024.0 5513.7 True False 4683.328205292032 6340.068597736646 4624.36359093904 4794.402124680591 5171.975168997803 5136.506388962659 5460.967949649569 4620.023315144188 5131.507135778569 6221.437102986065 0.752772732049996 1.0190681819629168 0.7432950802828999 0.7706261504081512 0.8313151902661592 0.8256141312587283 0.8777663197830131 0.7425974479315629 0.8248105784619492 1.0 12.603032154708425 -8.62043669553814 19.513894502566806 1.000000000176964 0.8226331147558333 0.31760315836522546 0.07873760219361271 36163.15016044521 7233477.1399666965 0.07404645607638728 0.019118712712822596 2.3964220361347424e-09 8.62043669553814 -0.17736688542113066 KPPAPPS(ph)PVQSQSPS(ph)TNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R1 1 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.471)PVQS(0.098)QS(0.436)PS(0.465)T(0.465)NWS(0.065)PAVPVKK 60.133 0.016459 20799000.0 3904.3 3853.3 5423.6 5238.2 4683.8 4343.6 4485.5 4331.2 2174.7 3319.8 True False 3995.262593554672 3402.153844649429 4687.10490970229 4323.446703192029 4260.151116992055 4299.907327673254 4147.155123703232 4216.3225062796355 3690.307066196314 3745.928667590392 1.066561311784046 0.9082270770622818 1.2512531138819896 1.1541721924921577 1.1372750244420544 1.1478882032313806 1.1071100097511823 1.1255746920006968 0.985151452061724 1.0 11.871107711767488 -8.262835077847194 24.81016743316837 0.9925757085893488 1.1133370180453368 0.2547657384699229 0.08186086098106275 167.20796035478637 2972135.8215833283 0.06939227477274892 0.021593315819659797 5.45965150516627e-09 8.262835077847194 0.12076130945598795 KPPAPPS(ph)PVQSQSPSTNWS(ph)PAVPVK ddPTM_A459_Selumetinib_30min_R1 1 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.97)PVQS(0.031)QS(0.043)PS(0.087)T(0.07)NWS(0.799)PAVPVK 65.736 0.005283100000000001 17565000.0 3147.1 3832.7 3416.0 3877.4 3515.8 3562.1 3868.6 3156.5 1664.5 3066.9 True False 3220.421306809395 3383.9657022261085 2952.125962744861 3200.284877812375 3197.7965107649065 3526.268508128024 3576.78838737227 3072.779366242998 2824.5349297299704 3460.566489135781 0.9306052396102471 0.977864668357 0.8530759261562709 0.9247864151315852 0.9240673516327967 1.0189859143578113 1.0335846453467545 0.8879411437086342 0.816205941598698 1.0 11.75679250870047 -4.439451982386057 15.548081849823046 0.9370718482109966 0.8025762038672392 0.0008792097199870064 0.06785749627123444 2663193.413233356 8189699.267654256 0.017757253097849663 12006116.362282427 3.635364966067554e-05 4.439451982386057 -0.1344956443437575 KPPAPPS(ph)PVQSQSPSTNWS(ph)PAVPVK ddPTM_A459_Selumetinib_30min_R2 1 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.635)PVQS(0.114)QS(0.237)PS(0.13)T(0.119)NWS(0.764)PAVPVK 74.494 0.0008003999999999999 7419000.0 105300.0 91325.0 114900.0 116280.0 131960.0 99975.0 98057.0 110410.0 101270.0 112380.0 True False 99447.84754929843 98329.33384384187 107507.45909366122 100442.46340581142 115382.00506263206 113745.64876730926 102616.8447962594 110731.27482064054 121526.82972021803 109135.29740169423 0.9112344944024919 0.9009856222952428 0.9850842179680748 0.9203480981603311 1.057238197078857 1.0422443652546776 0.9402718207525255 1.0146238426700025 1.113542846480862 1.0 16.7357582594207 -5.782879489238581 1.013364325698739 1.0254913230865998 0.9015191384756601 0.4651734809994693 0.048880747676582764 0.6056698935067679 1.1861476746486375 0.019764183683192316 0.05714268511635156 1.6486197974399647e-06 5.782879489238581 -0.12397218461093973 KPPAPPS(ph)PVQSQSPSTNWSPAVPVK ddPTM_A459_Selumetinib_30min_R2 2 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KPPAPPS(0.962)PVQS(0.024)QS(0.011)PS(0.001)T(0.001)NWSPAVPVK;KPPAPPS(0.998)PVQS(0.002)QSPSTNWSPAVPVK 86.434 4.5134e-05 42184000.0 251910.0 208788.0 240050.0 256160.0 273700.0 187077.0 217699.0 240100.0 238450.0 227730.0 True False 237909.85067562945 224801.36824076687 224605.44434667868 221270.56609935212 239315.35909095468 212845.1586340777 227822.43486238475 240798.65124930537 286146.6628496692 221154.84318640188 1.0757614314379067 1.0164885606927065 1.0156026479481999 1.0005232664647217 1.0821167451858429 0.9624259435940984 1.0301489742657954 1.0888237751426795 1.2938747292479078 1.0 17.75469731135796 -7.993027540445764 5.910282543289002 1.1615698419974299 1.0259126789372972 0.30079023424994544 0.07364255116575719 0.1483943523042291 19.883042949796444 0.04095259041070704 0.01783528095389435 1.0161842502959515e-08 7.993027540445764 -0.13565716306013265 KPPAPPS(ph)PVQSQSPSTNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R1 1 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KPPAPPS(0.449)PVQS(0.184)QS(0.034)PS(0.149)T(0.184)NWSPAVPVKK 68.834 0.00042223 37931000.0 4062.0 3788.7 5945.3 6167.1 4854.5 3954.1 4433.9 4026.5 2205.4 3689.3 True False 4156.636696723889 3345.117242681155 5137.960915195262 5090.13175580458 4415.411332131585 3914.3253440355466 4099.447353246629 3919.7041400847215 3742.402723957031 4162.857591825175 0.998505619045556 0.8035627375892318 1.2342389336798234 1.222749431976809 1.060668359350645 0.9402976819870839 0.9847676176328808 0.9415897742411493 0.8989984983647257 1.0 12.02335849049027 -6.746793964781075 9.771921824071308 0.9514333641146326 1.0678620967636578 0.18728907177677856 0.11525031848161064 0.4487491696607546 271.92014553576007 0.04248157281195192 0.041336981638170615 1.791455543383342e-07 6.746793964781075 0.1164287326490252 KPPAPPS(ph)PVQSQSPSTNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R2 1 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KPPAPPS(1)PVQSQSPSTNWSPAVPVKK 99.603 8.878299999999998e-07 14607000.0 40803.0 39068.0 49073.0 43631.0 47326.0 34722.0 29939.0 26552.0 25457.0 40041.0 True False 38535.33260735063 42064.38997658055 45915.696606642574 37688.38253232686 41380.4847801919 39504.64032506637 31331.222823003038 26629.261924079783 30549.11132801014 38884.912290988 0.9910098888478556 1.0817663586791586 1.1808100854912826 0.9692289454144287 1.0641784265971528 1.0159374934278043 0.8057424069402976 0.6848224762551773 0.7856289117846417 1.0 15.246922864187232 -7.223810651515296 3.747962822124084 0.7898396807509052 1.0587282853249402 0.6028635071701762 0.09134305505038555 0.1416939459704477 4.266075118586589 0.03717849017492311 0.02691538972629146 5.972956453473453e-08 7.223810651515296 0.2688886045740351 KPPAPPSPVQS(ph)QS(ph)PSTNWSPAVPVK ddPTM_A459_Selumetinib_30min_R2 1 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.179)PVQS(0.796)QS(0.654)PS(0.192)T(0.178)NWS(0.002)PAVPVK 60.728 0.015986 7707100.0 32262.0 28569.0 35398.0 31545.0 39163.0 28336.0 33896.0 36050.0 28980.0 32783.0 True False 30469.00719501865 30760.1504361864 33120.53121842834 27248.516581839755 34242.99381833783 32239.026791402597 35472.23116364978 36154.89953160124 34776.80976885469 31836.46960953673 0.9570472972886275 0.9661922572901138 1.0403330402095516 0.8558900190892197 1.0755901718474532 1.0126445295851925 1.1142011535419727 1.1356441205645147 1.092357607340896 1.0 14.958392741837933 -6.664060688236269 1.860090556659922 1.0903955858616272 0.9639098731388924 0.4259377924788401 0.061076878482237924 0.3044772855885231 2.1660169401197416 0.023410374669439283 0.022992813196749767 2.167401211384232e-07 6.664060688236269 -0.1264857127227348 KPPAPPSPVQS(ph)QS(ph)PSTNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R2 1 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 KPPAPPS(0.332)PVQS(0.722)QS(0.756)PS(0.149)T(0.04)NWS(0.001)PAVPVKK 66.3 0.016 4217000.0 17071.0 21231.0 20804.0 24052.0 23825.0 14385.0 13361.0 15384.0 11740.0 20266.0 True False 16122.262160627466 22859.349431575243 19465.493289682552 20776.076107985748 20831.89050179758 16366.403175971422 13982.31297431924 15428.764893041704 14088.328043007381 19680.86792260839 0.8191845107657586 1.1615010842746205 0.9890566496471211 1.0556483682368112 1.0584843404119872 0.8315895030813413 0.7104520506566208 0.7839473824890575 0.7158387576405316 1.0 14.264506224212012 -6.844682393501262 4.865999812243535 0.7834444585406434 1.0252918563649873 0.4672199239917577 0.11036025519150096 0.16069669978898246 6.698504604791103 0.037011467671985834 0.032849098339386054 1.429939313706058e-07 6.844682393501262 0.24184739782434395 KPPAPPSPVQS(ph)QSPSTNWSPAVPVKK ddPTM_A459_Selumetinib_30min_R1 1 KPPAPPSPVQSQSPSTNWSPAVPVKK 26 2 A9Z1X7;Q8IYB3;Q8IYB3-2 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KPPAPPS(0.008)PVQS(0.895)QS(0.032)PS(0.032)T(0.032)NWSPAVPVKK 107.21 1.1807e-08 35917000.0 3672.1 3895.6 4946.7 5257.7 4449.2 3550.3 3714.6 3587.6 2306.0 3255.9 True False 3757.6527853372236 3439.501340984692 4274.965310278103 4339.541394252364 4046.770645570062 3514.587205414484 3434.4047313583833 3492.445193832843 3913.113576423737 3673.826480151681 1.0228171650562226 0.9362176900751952 1.163627442225198 1.181204778640824 1.1015138214701372 0.9566557441954573 0.9348304145318772 0.9506287824700557 1.0651329336224329 1.0 11.843067772260932 -6.761291667317863 24.999999844962485 0.975450166939499 1.0831773755312453 0.3174260617713446 0.07274841013500886 5.219223868261729 883386.7282110617 0.02749612414214287 0.025845203417037534 1.7326399852888806e-07 6.761291667317863 0.10772720859174623 KPPAPPSPVQSQS(ph)PSTNWSPAVPVK ddPTM_A459_Selumetinib_30min_R2 1 KPPAPPSPVQSQSPSTNWSPAVPVK 25 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KPPAPPSPVQS(0.102)QS(0.502)PS(0.193)T(0.193)NWS(0.009)PAVPVK 79.445 0.00011122 3599800.0 35997.0 35091.0 40766.0 40505.0 38549.0 30437.0 38707.0 37300.0 34886.0 35743.0 True False 33996.4308474083 37782.36686465106 38143.159942664795 34988.149124977645 33706.12998756748 34629.42047042351 40506.952196465434 37408.53682465258 41864.174796282416 34711.00671853309 0.9794135653592766 1.0884837530361253 1.0988779510765152 1.0079842802800814 0.9710501991741691 0.9976495568460128 1.1669771644749716 1.0777139691739108 1.2060778051110246 1.0 15.083105587607779 -7.25442389528911 24.993552640498887 1.1191683996331019 1.0271260944663996 0.3113809358144852 0.06428674988130295 674.9828832091968 2404719.128675335 0.024859284115341884 0.01880720747578598 5.566421703348648e-08 7.25442389528911 -0.09204230516670231 KPPEADMNIFEDIGDYVPS(ph)TTKTPR ddPTM_A459_Selumetinib_30min_R1 2 KPPEADMNIFEDIGDYVPSTTKTPR 25 2 Q13123 Q13123 IK Protein Red 1 KPPEADMNIFEDIGDY(0.039)VPS(0.24)T(0.24)T(0.24)KT(0.24)PR;KPPEADMNIFEDIGDY(0.038)VPS(0.241)T(0.241)T(0.241)KT(0.241)PR 50.851000000000006 0.012881 33428000.0 3406.1 3917.4 5159.4 5031.299999999999 3568.5 3603.6000000000004 3863.6 3564.7 1989.3000000000002 2554.3 True False 3485.4555028831232 3458.7489868501466 4458.781818555571 4152.677904198015 3245.7298050698473 3567.3510558070097 3572.165541397795 3470.152576222529 3375.6968072765603 2882.1692859889536 1.2093167184269558 1.2000506020462127 1.547022876217223 1.44081679184681 1.1261412786709875 1.2377312717712037 1.239401709942268 1.2040072014825534 1.1712347444984528 1.0 11.492939360245591 -6.268288301497569 24.923174030339542 1.1808344378196725 1.352763889913937 0.3804371610417472 0.11505531845437239 644.1045432413187 2343887.5627942774 0.03746048284833095 0.04339449095547797 5.391525933183088e-07 6.268288301497569 0.17192945209426447 KPPLS(ph)PAQTNPVVQR ddPTM_A459_Selumetinib_30min_R1 1 KPPLSPAQTNPVVQR 15 1 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 KPPLS(0.702)PAQT(0.298)NPVVQR 124.04 0.0024635 10579000.0 1326.9 1771.7 1699.3 1769.2 1616.6 1463.0 1679.4 1495.6 978.33 1422.9 True False 1357.8141883020503 1564.2685403590162 1468.5443935867515 1460.2424319971244 1470.378815433912 1448.2835482977182 1552.7215059073023 1455.931829606534 1660.1545556039196 1605.5430752197012 0.8457039921624327 0.9742924774191829 0.9146714381274368 0.9095006260092436 0.9158139934879708 0.902052128436066 0.9671004969423378 0.9068158008823932 1.0340143352284368 1.0 10.64884565640419 -8.259969577283874 24.99908409867761 1.0170071757654102 0.9197094658407171 0.5725699354232957 0.034501187366125126 86.46228920590578 1470656.7492594912 0.024603202297722206 0.008179789269252532 5.495793710347457e-09 8.259969577283874 -0.09729770992469311 KPPLS(ph)PAQTNPVVQR ddPTM_A459_Selumetinib_30min_R2 2 KPPLSPAQTNPVVQR 15 1 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 KPPLS(0.995)PAQT(0.005)NPVVQR;KPPLS(0.989)PAQT(0.011)NPVVQR 128.44 0.00049791 64729000.0 218656.0 177621.0 206926.0 193358.0 195299.0 147287.0 132673.0 182363.0 124049.0 164163.0 True False 206503.9748693201 191243.95955846758 193612.6064439938 167022.30683884505 170763.79362478762 167574.44731173455 138842.5573865622 182893.64613817993 148862.266218656 159423.1876433025 1.295319570019873 1.1995993957062363 1.2144570015573117 1.0476663357939187 1.0711352354016337 1.051129699442906 0.8709056658508929 1.1472211090609408 0.9337554242844789 1.0 17.282501954863598 -5.608567372256556 0.8558539633603854 0.9999036131131708 1.3063865399505603 0.6666783059505065 0.07225570532252995 0.547494021796492 0.6596260048433199 0.029416773531688072 0.1267115948079439 2.462819750500404e-06 5.608567372256556 0.30648292683738954 KPPQHLSPDT(ph)TGPPPPPLETLEAEFGSLK ddPTM_A459_Selumetinib_30min_R1 1 KPPQHLSPDTTGPPPPPLETLEAEFGSLK 29 1 A0A3B3ISF0;A0A3B3IT29;A0A3B3ISF8 A0A3B3ISF0 1 KPPQHLS(0.044)PDT(0.477)T(0.477)GPPPPPLET(0.002)LEAEFGSLK 60.343 0.0019039000000000005 4094200.0 794.22 1004.4 839.98 1109.9 821.3 762.42 907.02 927.94 402.45 608.0 True False 812.7237807169006 886.804381067108 725.9153296798677 916.0768004033513 747.0135600122919 754.7507470219729 838.6027511540084 903.3280168260818 682.9282562149751 686.0427224215183 1.1846547658843132 1.292637254334487 1.0581197146405277 1.3353057622561522 1.088873237187861 1.1001512330863834 1.222376863344604 1.3167226869452295 0.9954602445230377 1.0 9.422154610934454 -8.285864641190692 24.30019686655388 0.9977299523916565 1.1964662843439342 0.43786633655674057 0.09154270393867152 584.5823544119239 581581.1321765152 0.08570868006064479 0.022179013313705583 5.1776818229442535e-09 8.285864641190692 0.1987363319522777 KPPTSPSS(ph)PPAPVPR ddPTM_A459_Selumetinib_30min_R2 1 KPPTSPSSPPAPVPR 15 1 O75161-2;O75161 O75161-2 NPHP4 Nephrocystin-4 1 KPPT(0.001)S(0.011)PS(0.235)S(0.752)PPAPVPR 67.64399999999999 0.030659 5162700.0 24156.0 25689.0 29470.0 25105.0 26670.0 20407.0 22554.0 24891.0 22193.0 25638.0 True False 22813.506224129636 27659.263696845952 27573.93228450993 21685.65569145941 23319.476167174886 23217.879013698213 23602.805689903144 24963.42868907312 26632.220124230233 24897.764324476186 0.9162873391689397 1.1109135477539653 1.1074862756815034 0.8709880698059683 0.9366092418286032 0.9325286684826344 0.9479889592616952 1.0026373598746126 1.0696631142117832 1.0 14.603728581971401 -5.746728608256464 24.999990450333947 0.9625420872818051 1.0514974832752917 0.2069434828447314 0.07042706826261688 354.23540281928496 601994.8459848769 0.019654024887245394 0.03385782888446819 1.7917251579501952e-06 5.746728608256464 0.08895539599348656 KPQEEDS(ph)PGPSTSSVLK ddPTM_A459_Selumetinib_30min_R2 1 KPQEEDSPGPSTSSVLK 17 1 A0A182DWI4;E9PN30;Q9BQE4 A0A182DWI4 VIMP Selenoprotein S 1 KPQEEDS(0.999)PGPSTSSVLK 80.277 0.008604500000000001 3731400.0 18978.0 10146.0 21091.0 21771.0 11841.0 11471.0 35074.0 17555.0 25311.0 16737.0 True False 17923.27873495333 10924.165575468067 19734.02802214453 18805.752242930204 10353.427720116904 13051.026126629697 36705.010497812495 17606.082143613294 30373.907248429317 16253.759322051552 1.1027158935863368 0.6721008573473338 1.214120846207639 1.157009395199814 0.6369866512093827 0.8029543115556848 2.258247447285296 1.0832006180703708 1.8687312052923593 1.0 13.988485816338365 -7.20870034946579 24.999332079168795 1.5594808472880628 0.9289944162560494 0.3892690242698871 0.3813645504051509 323.68036502916794 153430.86202867326 0.13741718689661117 0.10644282070390308 6.184429605815126e-08 7.20870034946579 -0.6304864310320134 KPRPLS(ph)MDLTAR ddPTM_A459_Selumetinib_30min_R2 1 KPRPLSMDLTAR 12 2 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 KPRPLS(0.997)MDLT(0.003)AR 63.212 0.033411 7547500.0 25873.0 30616.0 29650.0 27915.0 30455.0 24720.0 16700.0 22283.0 17006.0 25592.0 True False 24435.08223782523 32964.148754044 27742.351280479124 24112.92884393905 26628.970628845553 28124.95561418238 17476.58309042222 22347.83984085078 20407.675187341025 24853.09246399853 0.9831807560053616 1.3263600415841574 1.1162534932288966 0.9702184498314783 1.071455017817984 1.1316481301038643 0.7031955124191603 0.8991975494889906 0.8211322279874422 1.0 14.601137756684807 -7.244168032527285 24.633618991563537 0.8474811159280682 1.1037106839979742 0.5203290746489884 0.1146070897481158 523.9385723331744 747279.2294248976 0.043805738847376895 0.033843741563286726 5.6994371315351554e-08 7.244168032527285 0.25622956806990604 KPRPS(ph)EGDEDCLPASK ddPTM_A459_Selumetinib_30min_R1 1 KPRPSEGDEDCLPASK 16 2 Q5VU10;P78346;P78346-2 Q5VU10 RPP30 Ribonuclease P protein subunit p30 1 KPRPS(1)EGDEDCLPASK 93.215 0.011507 15306000.0 3669.6 4111.7 4588.2 4602.1 4054.2 4536.0 5099.6 4962.6 2654.6 4076.3 True False 3755.0945402013776 3630.3002525225293 3965.1476411785625 3798.4296271161925 3687.4983258271473 4490.3719583584725 4714.933066288485 4830.975727203391 4504.6623156871 4599.532811524404 0.8164078166358036 0.7892758680678602 0.8620761724416116 0.8258294445903289 0.8017114948257137 0.9762669693555784 1.0250895600690006 1.0503187878340803 0.9793738843215555 1.0 12.16727161436948 -6.843761352948064 4.291202747214096 1.0156004820663054 0.8199151623372899 0.9331644425559913 0.025146352366818666 0.05147071381567985 1.7672208466803025 0.009277748491058453 0.00825091678547226 1.4329751101601688e-07 6.843761352948064 -0.19568531972901548 KPRPS(ph)EGDEDCLPASK ddPTM_A459_Selumetinib_30min_R2 2 KPRPSEGDEDCLPASK 16 2 Q5VU10;P78346;P78346-2 Q5VU10 RPP30 Ribonuclease P protein subunit p30 1 KPRPS(1)EGDEDCLPASK;KPRPS(1)EGDEDCLPASK 130.47 0.00088628 113891000.0 118977.0 93400.0 113991.0 115710.0 106398.0 80361.0 92867.0 103850.0 88658.0 113368.0 True False 112364.73464266743 100563.47967166541 106656.94316401682 99950.09838911655 93031.3320298115 91429.99830547375 97185.4995124694 104152.18630670712 106392.07731149466 110094.77127456162 1.020618266806194 0.9134264825426955 0.9687739202257725 0.907855089138197 0.8450113566047911 0.830466308681087 0.8827440067076553 0.9460230045527368 0.9663681215719779 1.0 16.748386427123037 -10.9496510339838 10.591283012796392 1.0000000714413306 0.9158282305572457 0.15354750038148868 0.055421832611421536 1.0125773826848623e-07 5.436532539738985e-09 0.058106997088292305 0.014093004782703701 1.1229203853118727e-11 10.9496510339838 -0.08417184088408491 KPS(ph)DGSPDTKPSR ddPTM_A459_Selumetinib_30min_R2 1 KPSDGSPDTKPSR 13 2 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 KPS(0.941)DGS(0.004)PDT(0.044)KPS(0.01)R 107.82 0.0073309 22805000.0 29201.0 29459.0 22872.0 30112.0 28385.0 21567.0 24416.0 25996.0 19108.0 32539.0 True False 27578.12532086479 31718.410574385358 21400.440421150717 26010.693653902643 24819.02253488034 24537.658484266638 25551.39237938616 26071.64405613054 22930.133922128214 31599.514523524867 0.8727388928818424 1.003762591060441 0.6772395318041594 0.8231358628797439 0.7854241721468012 0.7765201096997584 0.808600789115413 0.825064702709942 0.725648297699556 1.0 14.947614773398557 -5.247829139414764 24.997899387768232 0.795844498009741 0.9382507398204376 0.288696511882215 0.08455833003288779 863.875510349937 1586671.939472057 0.01957316351410886 0.051156142522379815 5.651592766287544e-06 5.247829139414764 0.1424062418106966 KPS(ph)EDEVLNK ddPTM_A459_Selumetinib_30min_R1 4 KPSEDEVLNK 10 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 KPS(1)EDEVLNK;KPS(1)EDEVLNK;KPS(1)EDEVLNK;KPS(1)EDEVLNK 143.25 0.0019944000000000003 128068000.0 14132.3 18277.4 18785.0 21384.4 16306.4 17372.9 20209.0 20326.699999999997 11753.599999999999 15060.5 True False 14461.555093331119 16137.473511067261 16234.100178618908 17650.01597490353 14831.488999128747 17198.144399331122 18684.61885964076 19787.56988557311 19945.000751020823 16993.66187669289 0.8509969892460552 0.9496171942316972 0.955303235783705 1.0386234646171724 0.8727659233628978 1.012032869908909 1.0995051564058154 1.1644088266056483 1.1736729196887072 1.0 14.052709144496783 -7.155606844565964 2.841024651549476 1.126151868494204 0.9412844614686855 0.607693209549694 0.06577799906796526 0.17962564359237096 2.803842952690231 0.027724030978968233 0.020281750753274867 6.988647818022869e-08 7.155606844565964 -0.18486740702551852 KPS(ph)EDEVLNK ddPTM_A459_Selumetinib_30min_R2 4 KPSEDEVLNK 10 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 KPS(1)EDEVLNK;KPS(1)EDEVLNK;KPS(1)EDEVLNK;KPS(1)EDEVLNK 150.26 0.001287 166654000.0 257038.0 212103.0 230855.0 232509.0 199638.0 156633.0 219691.0 192366.0 153732.0 240500.0 True False 242752.85696463948 228370.61808136263 216002.04063591934 200840.8730996033 174557.68965363555 178207.7739771938 229907.06680945813 192925.75321209445 184482.6956309717 233556.1401059565 1.0393769003654143 0.9777975350070378 0.9248399144545142 0.8599254680630045 0.747390711177384 0.7630190064639147 0.9843760335530339 0.8260358863807673 0.7898858730379692 1.0 17.83340984800126 -5.383894029790564 1.7846885887843513 0.8430142627437935 1.0269999409574906 0.3779579947300198 0.0803181206959833 0.41167885990378944 2.4037321569419285 0.02384060096930371 0.08374025970742528 4.131483001183878e-06 5.383894029790564 0.18398567821369705 KPS(ph)PAASPATK ddPTM_A459_Selumetinib_30min_R2 1 KPSPAASPATK 11 1 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 KPS(1)PAASPATK 95.236 0.010998 115210000.0 293210.0 255060.0 276810.0 293360.0 279180.0 193630.0 256330.0 245340.0 239450.0 243290.0 True False 276914.56201262865 274622.2818528374 259000.3459679399 253403.8619257732 244106.91249913297 220300.7749018664 268249.8529082592 246053.89878177625 287346.6907920033 236265.58555666573 1.1720478095029787 1.1623456763954827 1.0962254420495003 1.0725381833699053 1.0331886123998646 0.9324285396149227 1.135374211509625 1.0414292805363432 1.2162020554749238 1.0 17.850049976103485 -5.383867110188304 2.0653366468401035 1.059550714975013 1.174149385829642 0.25533427493547034 0.07150672542083542 0.48882372604808444 3.923189525681686 0.020578145667313325 0.06412839908885995 4.131739097751402e-06 5.383867110188304 0.11459867085462894 KPS(ph)PEPEGEVGPPK ddPTM_A459_Selumetinib_30min_R1 4 KPSPEPEGEVGPPK 14 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK 176.42 0.00012438 70938000.0 22550.6 26803.399999999998 25645.7 27165.0 23744.0 21752.9 26848.6 27093.4 12942.5 23135.1 True False 23075.98510417078 23665.24546743741 22163.15480174644 22421.142700204542 21596.359392343667 21534.085576052916 24823.388486068132 26374.79502023381 21962.47721720046 26104.715439957352 0.8839776536636509 0.9065506008624805 0.8490096301843714 0.8588924384858635 0.8272972537094605 0.8249117147276629 0.9509158812002237 1.0103460074444275 0.8413222227116658 1.0 14.672022811914665 -7.275672893321422 23.842700942251124 0.9515082158858984 0.8588030832133117 0.4689192430783363 0.04806806697874634 397.8790187213068 666487.1065209822 0.019797180138833796 0.01342747521630789 5.300625318863206e-08 7.275672893321422 -0.09270513267258673 KPS(ph)PEPEGEVGPPK ddPTM_A459_Selumetinib_30min_R2 6 KPSPEPEGEVGPPK 14 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK;KPS(1)PEPEGEVGPPK 137.69 0.00030028 282608200.0 566423.0 487103.0 520044.0 562700.0 561795.0 417865.0 517080.0 530628.0 406145.0 473680.0 True False 534943.4772309237 524462.2338169927 486584.9352210958 486059.2892883587 491217.28958897665 475422.11074920406 541125.2445745821 532172.0396298057 487385.34863945824 460003.62763155764 1.1629114317754676 1.1401262996931485 1.0577849955801406 1.0566422960422184 1.0678552517468836 1.0335181772305413 1.1763499504573456 1.1568866149378538 1.059525011028461 1.0 18.81128571287912 -5.111685881721599 4.789189604019629 1.0829246629326073 1.1579280542885386 0.25788246904374634 0.050676587914794395 0.3256286013035047 11.258509154612177 0.0136926384572643 0.040055579981923065 7.732396548091901e-06 5.111685881721599 0.07500339135593137 KPS(ph)PQPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 KPSPQPSSPR 10 1 G3V5E1;O75909-1;O75909;O75909-4 G3V5E1 CCNK Cyclin-K 2 KPS(1)PQPS(0.819)S(0.182)PR 98.253 0.020014 0.0 83617.0 68614.0 77099.0 79580.0 90885.0 74018.0 57803.0 67602.0 55946.0 70231.0 True False 78969.90188537215 73876.4731712167 72138.534279044 68741.06671684278 79467.21377779104 84213.30763149483 60490.95403447154 67798.7106278865 67136.76326184756 68203.24854794792 1.157861297909514 1.0831811496380617 1.0576993884437853 1.0078855212962 1.1651529138223435 1.2347404181531263 0.8869218889470563 0.9940686414698117 0.9843631306601092 1.0 16.057552836576008 -7.272691091745633 24.93782609950755 0.9658441391974204 1.1106127775733134 0.5584956892144604 0.06576843413591169 622.954921150762 1380685.2880481265 0.02927910804122869 0.01994003910597281 5.3371438490133235e-08 7.272691091745633 0.14476863837589304 KPS(ph)PQPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 KPSPQPSSPR 10 1 G3V5E1;O75909-1;O75909;O75909-4 G3V5E1 CCNK Cyclin-K 2 KPS(1)PQPS(0.025)S(0.975)PR;KPS(1)PQPS(0.045)S(0.956)PR 137.81 0.005734899999999999 21079000.0 11206.6 13533.400000000001 14186.7 15136.7 12565.0 11239.3 12493.2 10839.0 6564.9 10219.2 True False 11467.691975752325 11948.903236493035 12260.224061965027 12493.359496049565 11428.497968530932 11126.242846467896 11550.82786566697 10551.514509966044 11140.155818674852 11530.933863437465 0.9945154582938274 1.0362476602507344 1.06324641240377 1.0834646737211615 0.9911164268115925 0.9649038818744098 1.0017252724250363 0.9150615756650045 0.966110459968754 1.0 13.493221737776956 -6.461852075462982 5.27248323093486 0.9672216660548761 1.0449528087587452 0.5695082581098717 0.03074686806001048 0.15792950676838027 8.970418950023191 0.010113731924033365 0.011305893718621554 3.45261318365505e-07 6.461852075462982 0.07773114270386905 KPS(ph)PSESPEPWKPFPAVSPEPR ddPTM_A459_Selumetinib_30min_R1 1 KPSPSESPEPWKPFPAVSPEPR 22 2 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPS(0.368)PS(0.316)ES(0.316)PEPWKPFPAVSPEPR 52.169 0.015757 74609000.0 2546.2 1850.6 2405.6 2623.4 2294.9 1829.8 1818.0 1858.7 1347.5 1847.1 True False 2605.521505957254 1633.9308916794005 2078.9327330149404 2165.2724373170113 2087.3267001975023 1811.3938733254708 1680.8667963198036 1809.4012380915128 2286.609082493923 2084.1932772776104 1.250134301057053 0.7839632290790487 0.997475980601213 1.038901939145158 1.0015034224292216 0.8691103138436027 0.8064831676817252 0.8681542435713865 1.0971194981881478 1.0 11.025273356539751 -6.74186166373711 23.641132943185543 0.9123274574230177 1.0020154999179587 0.09006435520630696 0.12936297681627507 315.6372185250454 381146.4915564321 0.04194652448994252 0.041873123381527246 1.8119171525218468e-07 6.74186166373711 0.089688042494941 KPS(ph)PSESPEPWKPFPAVSPEPR ddPTM_A459_Selumetinib_30min_R2 1 KPSPSESPEPWKPFPAVSPEPR 22 2 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPS(0.555)PS(0.39)ES(0.055)PEPWKPFPAVSPEPR 51.942 0.016365 9203400.0 22508.0 19416.0 23857.0 24207.0 19231.0 18203.0 19455.0 16404.0 15927.0 19274.0 True False 21257.095466662937 20905.144767720078 22322.066593537613 20909.964840595832 16815.029852678676 20710.29801961821 20359.696049351143 16451.732924171618 19112.845037562074 18717.509540133928 1.1356796918459504 1.116876405105895 1.1925767445543343 1.1171339218906693 0.8983582894200763 1.1064665400710154 1.0877353103892402 0.8789488200284311 1.0211211591253886 1.0 14.192100869325497 -6.068011055092252 8.68803988800019 1.0027484562986322 1.1468472690326763 0.506285428744218 0.06904115842119865 0.3283516682280313 39.6625546985802 0.020766043770197126 0.026905742598756263 8.550449471900338e-07 6.068011055092252 0.14409881273404412 KPS(ph)SETDIENWASK ddPTM_A459_Selumetinib_30min_R1 1 KPSSETDIENWASK 14 1 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 KPS(0.692)S(0.308)ETDIENWASK 107.98 0.0090384 11282000.0 876.79 1121.3 892.89 1272.3 1061.2 1142.6 1151.6 1239.3 692.45 1093.1 True False 897.2175010636481 990.0176747217722 771.640442293694 1050.1166890289073 965.2146473700777 1131.1064813977944 1064.7338848415206 1206.4297381862648 1175.0370754529997 1233.410032695661 0.7274284117040525 0.8026671167560181 0.6256155064729341 0.8513930170762763 0.7825578046098484 0.9170563327798797 0.8632440604642297 0.9781254458823967 0.9526735183797029 1.0 10.268436771181793 -6.900138638301246 0.6671845098058246 0.9896500841078636 0.7226947485382194 0.7326607130657149 0.05810597650759987 0.3770741868042453 0.360307733101925 0.044297396893343395 0.040622824157721435 1.2585235935980357e-07 6.900138638301246 -0.26695533556964424 KPS(ph)TSDDSDSNFEK ddPTM_A459_Selumetinib_30min_R2 2 KPSTSDDSDSNFEK 14 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 KPS(0.983)T(0.016)S(0.001)DDSDSNFEK;KPS(0.974)T(0.025)S(0.001)DDSDSNFEK 140.28 0.00028943 19573700.0 148265.0 124474.0 144595.0 110313.0 106520.0 111715.0 107396.0 121095.0 102915.0 129236.0 True False 140025.0248518208 134020.7555530071 135291.91512313235 95288.17909946085 93138.0052991176 127102.72720220017 112390.1268011368 121447.36640164361 123500.87568535822 125504.6208845463 1.1156961701086054 1.067855148347844 1.0779835369375725 0.7592404042805561 0.7421081761188438 1.0127334460388036 0.895505886628081 0.967672469313819 0.9840344906421306 1.0 16.937380957373755 -5.653229774837205 10.272791180852012 0.9043327936250422 1.0868653806395714 0.4552040401850521 0.08939889920614764 0.3085087331468597 27.29975898809624 0.025930038496487957 0.044934033554359785 2.2221339016135427e-06 5.653229774837205 0.18253258701452924 KPS(ph)VPDSASPADDSFVDPGER ddPTM_A459_Selumetinib_30min_R2 2 KPSVPDSASPADDSFVDPGER 21 1 C9K098;C9JVV5;H7C5C7;C9J869;C9JAB9;P16333-2;P16333 C9K098 NCK1 Cytoplasmic protein NCK1 1 KPS(0.973)VPDS(0.027)ASPADDSFVDPGER;KPS(0.984)VPDS(0.013)AS(0.004)PADDSFVDPGER 55.662 0.016394 8058600.0 40135.0 29491.0 31405.0 38916.0 37587.0 26541.0 37407.0 47159.0 45093.0 52656.0 True False 37904.45737313475 31752.86487148914 29384.436491178625 33615.57366615552 32864.985027956594 30196.78183479024 39146.49962056429 47296.22488240726 54112.860003691014 51135.68446328176 0.7412525669887579 0.6209531602982541 0.5746366123695532 0.6573799494224695 0.642701576656424 0.5905226878594574 0.7655417157596401 0.9249162376298797 1.0582210949488127 1.0 15.642042790693482 -7.724458873770141 2.070679340263709 1.0251078859034928 0.6353573830342397 0.9215682723508155 0.04692635852841585 0.08082515404388231 0.6842149948049164 0.03181513289020425 0.013680012377163804 1.8859975586734032e-08 7.724458873770141 -0.38975050286925306 KPS(ph)VSEEVQATPNK ddPTM_A459_Selumetinib_30min_R1 2 KPSVSEEVQATPNK 14 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 KPS(0.962)VS(0.038)EEVQATPNK;KPS(0.999)VS(0.001)EEVQATPNK 186.96 0.00015437 80238000.0 7663.700000000001 9650.3 11033.2 11290.4 9919.1 9252.9 10300.2 11261.8 6909.4 7222.9 True False 7842.249299035664 8520.438389697241 9534.952041029454 9318.743587056491 9021.919156359341 9159.824226961007 9523.247621261402 10963.1004805181 11724.747157390364 8150.0295720039185 0.9622356863556045 1.045448769776948 1.1699285207237613 1.1433999723224577 1.1069799289257112 1.1239007350876153 1.1684924008097604 1.3451608222597538 1.4386140631521045 1.0 12.992589578767275 -7.551233023987144 3.5007742893854013 1.2927076430494449 1.098022068014135 0.27802874378748965 0.11816025432138677 0.2658260937805174 6.895201752884494 0.0583064094721765 0.03287113048471132 2.8103924884452557e-08 7.551233023987144 -0.1946855750353098 KPS(ph)VSEEVQATPNK ddPTM_A459_Selumetinib_30min_R2 3 KPSVSEEVQATPNK 14 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 KPS(0.996)VS(0.004)EEVQATPNK;KPS(0.499)VS(0.499)EEVQAT(0.003)PNK;KPS(0.937)VS(0.063)EEVQATPNK 126.63 0.0023019000000000004 200817000.0 247911.0 229016.0 238156.0 274698.0 243648.0 214755.0 237782.0 253290.0 211240.0 272912.0 True False 234133.09908636374 246580.7907974956 222833.30224464755 237283.65851951877 213038.75999924378 244335.5518982096 248839.33415609453 254027.0319655835 253493.90253874572 265032.3214494673 0.8834133806997009 0.9303800738300149 0.8407778380612885 0.8953008343352596 0.8038218087293292 0.921908507467819 0.9389018395763469 0.9584756703495799 0.9564641065375812 1.0 18.01580878562742 -7.151588894314325 2.720414904931574 0.9623761445229394 0.8734894950743439 0.6041224099880337 0.03497686506734586 0.20624645131635297 2.961551760823891 0.015050397130458113 0.010975004004845164 7.053604513541896e-08 7.151588894314325 -0.08888664944859548 KPSDGS(ph)PDTKPSR ddPTM_A459_Selumetinib_30min_R1 1 KPSDGSPDTKPSR 13 2 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 KPS(0.01)DGS(0.989)PDT(0.001)KPSR 84.375 0.033035 2253000.0 1221.2 1202.1 1295.3 1543.8 1193.2 1108.0 1108.8 1335.8 853.58 900.81 True False 1249.6515839584476 1061.357573158871 1119.4053745736 1274.2043107151028 1085.2752706765696 1096.854525983508 1025.162323299998 1300.3702447100877 1448.4629169834243 1016.4377381324467 1.2294423328422424 1.0441933955629765 1.1013024532425775 1.2535979951475078 1.0677242982640547 1.0791162949132675 1.0085834919742172 1.279340776051197 1.4250385071738478 1.0 9.989306130303552 -7.784202403096676 24.945784627747983 1.2641423544670847 1.1114544237475634 0.16405360442561923 0.12173057675393148 334.04135033727397 366067.3557174531 0.06373045591602897 0.030649194482808985 1.6436055417460062e-08 7.784202403096676 -0.15268793071952125 KPSDGS(ph)PDTKPSR ddPTM_A459_Selumetinib_30min_R2 1 KPSDGSPDTKPSR 13 2 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 KPS(0.016)DGS(0.617)PDT(0.333)KPS(0.034)R 83.41799999999998 0.03512 21748000.0 22145.0 18631.0 17206.0 19613.0 19225.0 17008.0 17781.0 19600.0 13904.0 19033.0 True False 20914.269553458806 20059.93779189292 16098.984692476342 16941.675565687856 16809.78362631936 19350.697616748155 18607.851732383086 19657.032755045322 16685.188510219316 18483.46783632713 1.131512210731052 1.08529081065986 0.8709937353225264 0.9165853353768897 0.9094496647042426 1.0469192138672476 1.0067294674980576 1.0634926805462168 0.902708769694532 1.0 14.173947837651497 -5.076136489090356 6.776018057018921 0.9677882539938212 1.1207042791876196 0.4733076724387725 0.06144104570422242 0.19784999906889247 14.713574718766559 0.016748372441241784 0.045882252233975 8.391962043805754e-06 5.076136489090356 0.15291602519379843 KPSDGSPDT(ph)KPSR ddPTM_A459_Selumetinib_30min_R1 1 KPSDGSPDTKPSR 13 2 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 KPS(0.005)DGS(0.018)PDT(0.967)KPS(0.011)R 101.3 0.033224000000000004 38030000.0 7153.4 8110.7 8341.5 9104.5 7443.6 7670.0 7277.4 7035.5 4873.4 7008.6 True False 7320.060301906613 7161.095473437864 7208.7701165797025 7514.569987631593 6770.327694274317 7592.846763802796 6728.459858931646 6848.895685475241 8269.80386094685 7908.2220795451585 0.925626547696499 0.9055253382375592 0.9115538289226085 0.9502224282583366 0.8561124897827493 0.9601205792439631 0.8508182738488084 0.8660474651047174 1.0457222594111175 1.0 12.949137670215777 -8.26579043762633 24.9994759100721 1.0228611433891381 0.9037477924231048 0.63041939717485 0.036630307024288496 241.66937266039082 1388510.034199955 0.03046935068669998 0.00896506340440147 5.422624880183605e-09 8.26579043762633 -0.11911335096603337 KPSGS(ph)PDLWK ddPTM_A459_Selumetinib_30min_R2 1 KPSGSPDLWK 10 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPS(0.209)GS(0.791)PDLWK 73.722 0.033057 77042000.0 239870.0 206120.0 211860.0 247370.0 223070.0 166630.0 238360.0 238560.0 170860.0 186010.0 True False 226538.98567569064 221928.74121973928 198229.15825572694 213677.77926294864 195045.9523288979 189581.76998346348 249444.21230137986 239254.17010426626 205036.77422727752 180639.40798797918 1.2540950404950724 1.2285732315647744 1.0973749330983098 1.1828968088578324 1.079753053341923 1.0495039376794204 1.3808958691781106 1.3244849104033138 1.1350611503383685 1.0 17.462753137503775 -7.242102273734231 24.987996247470814 1.2371509265986693 1.148417695112622 0.044726317170659335 0.11438456381548415 1814.4055198133533 2344633.4702241844 0.04375089118958402 0.03384036557671553 5.726611568527904e-08 7.242102273734231 -0.08873323148604739 KPSLVSDLPWEGAAPQS(ph)PSFSGSEDSGSPK ddPTM_A459_Selumetinib_30min_R1 2 KPSLVSDLPWEGAAPQSPSFSGSEDSGSPK 30 1 Q13425;Q13425-2;H7BY41;H0YCS0 Q13425 SNTB2 Beta-2-syntrophin 1 KPSLVSDLPWEGAAPQS(0.997)PS(0.003)FSGSEDSGSPK;KPSLVSDLPWEGAAPQS(0.973)PS(0.02)FS(0.006)GSEDSGSPK 145.33 9.7159e-20 60216000.0 5066.9 6471.4 7454.3 7112.6 6540.1 6458.1 7044.0 7157.4 3731.3999999999996 5145.9 True False 5184.948911528871 5713.725479527763 6442.047003538943 5870.517930037728 5948.549109748435 6393.137377485638 6512.665408843064 6967.562501488235 6331.913269326775 5806.42639031068 0.8929673026047684 0.9840347737917405 1.1094684700195179 1.0110380353454576 1.0244767968943718 1.101045108942398 1.1216305815416694 1.1999743100360611 1.0905009111788597 1.0 12.50343480368136 -3.3413097425708593 0.5477335741333306 1.1056741198145141 9.792459840314874e-11 0.51550969948031 0.05780275978661036 14.001840860407698 0.9285950367195683 0.030747350675573833 13.975069704644614 0.0004557117824467086 3.3413097425708593 -1.1056741197165896 KPSLVSDLPWEGAAPQS(ph)PSFSGSEDSGSPK ddPTM_A459_Selumetinib_30min_R2 1 KPSLVSDLPWEGAAPQSPSFSGSEDSGSPK 30 1 Q13425;Q13425-2;H7BY41;H0YCS0 Q13425 SNTB2 Beta-2-syntrophin 1 KPSLVSDLPWEGAAPQS(0.999)PS(0.001)FSGSEDSGSPK 130.25 2.6706999999999998e-14 0.0 14226.0 11099.0 12642.0 12205.0 11712.0 10830.0 12033.0 10650.0 9665.8 15029.0 True False 13435.37587119012 11950.257611090088 11828.627483568862 10542.65794520065 10240.633853391537 12321.734195048357 12592.55834293716 10680.989736797586 11599.230085017098 14595.073719968497 0.9205418300017411 0.818787067497997 0.8104534249378491 0.7223435898632382 0.7016500258837775 0.844239257126202 0.862795117348975 0.7318215681352955 0.7947359710247585 1.0 13.83319387748551 -9.47119483196392 11.49705187868095 1.000000056687112 0.7974762825363249 0.46257529843191103 0.06431691420610683 0.0 0.0 0.06549599364277714 0.01588511175552665 3.3791320852787173e-10 9.47119483196392 -0.20252377415078704 KPSLVSDLPWEGAAPQSPSFSGS(ph)EDSGSPK ddPTM_A459_Selumetinib_30min_R2 1 KPSLVSDLPWEGAAPQSPSFSGSEDSGSPK 30 1 Q13425;Q13425-2;H7BY41;H0YCS0 Q13425 SNTB2 Beta-2-syntrophin 1 KPSLVSDLPWEGAAPQS(0.019)PS(0.136)FS(0.096)GS(0.325)EDS(0.23)GS(0.194)PK 76.274 2.1145e-05 8165200.0 48738.0 42189.0 35587.0 42000.0 36134.0 27345.0 38050.0 29722.0 25149.0 30362.0 True False 46029.33707367242 45424.76064098388 33297.371164195974 36279.52754595879 31594.523877941385 31111.525536804933 39819.400394644654 29808.486099258018 30179.5027217711 29485.37017005014 1.5610906971222924 1.5405864121429353 1.129284488278797 1.2304246932198881 1.071532210575183 1.0551512617062737 1.350479921567725 1.0109585169643243 1.0235415919053317 1.0 14.847711685940695 -5.259284347107113 5.140741084458006 1.1176245878887088 1.5577212974913306 0.7445677081068403 0.10348341625276962 0.08180671430775162 7.226960922368007 0.027235463316010948 0.0672706925555598 5.504471822372548e-06 5.259284347107113 0.4400967096026218 KPSLVSDLPWEGAAPQSPSFSGSEDS(ph)GSPK ddPTM_A459_Selumetinib_30min_R2 1 KPSLVSDLPWEGAAPQSPSFSGSEDSGSPK 30 1 Q13425;Q13425-2;H7BY41;H0YCS0 Q13425 SNTB2 Beta-2-syntrophin 1 KPSLVSDLPWEGAAPQS(0.006)PS(0.031)FS(0.021)GS(0.107)EDS(0.46)GS(0.376)PK 97.446 3.9455e-08 3425700.0 22036.0 18655.0 13616.0 14839.0 14511.0 10103.0 15520.0 16601.0 9110.7 15000.0 True False 20811.327337097242 20085.778514720747 12739.961383979891 12817.902601297204 12687.998450014047 11494.59654409728 16241.71075229658 16649.306161556506 10933.094574227214 14566.911025319543 1.4286712742958296 1.3788632661933995 0.8745822200627071 0.8799327859570027 0.8710150304316643 0.7890895004519417 1.1149728809399588 1.1429537897648607 0.7505431010887488 1.0 13.830407359839738 -5.25462549684283 22.1370138355411 0.9309725540046931 1.403767706797758 0.7115400130026647 0.12118696280508968 59.55971476639771 193490.169864367 0.032492215747429096 0.08139110896971585 5.563838343702138e-06 5.25462549684283 0.47279515279306494 KPSLVSDLPWEGAAPQSPSFSGSEDSGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KPSLVSDLPWEGAAPQSPSFSGSEDSGSPK 30 1 Q13425;Q13425-2;H7BY41;H0YCS0 Q13425 SNTB2 Beta-2-syntrophin 1 KPSLVSDLPWEGAAPQS(0.145)PS(0.109)FS(0.109)GS(0.082)EDS(0.071)GS(0.484)PK 102.31 1.233e-08 7619300.0 26733.0 27328.0 21632.0 22016.0 21580.0 14458.0 24942.0 20971.0 14108.0 19970.0 True False 25247.286880678017 29423.969726630326 20240.22067114077 19017.38282028164 18868.927472352236 16449.458263343407 26101.852421635376 21032.02213806405 16929.994210455563 19393.41421170877 1.3018484834627506 1.5172145247568432 1.0436646404902106 0.9806103563136346 0.9729554201425825 0.8481981606628116 1.345913212428392 1.0844930092487775 0.8729764664250859 1.0 14.243279191900468 -5.2744894227336685 22.810495369766507 1.024235785890653 1.4095314587120786 0.5629166688867251 0.13771888530143783 154.59435572477273 270220.6641003824 0.036916810566450416 0.07781430454605329 5.315089442789972e-06 5.2744894227336685 0.3852956728214256 KPSPQPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 KPSPQPSSPR 10 1 G3V5E1;O75909-1;O75909;O75909-4 G3V5E1 CCNK Cyclin-K 1 KPSPQPS(0.5)S(0.5)PR 87.719 0.017074000000000002 142560000.0 87902.0 68289.0 83592.0 90326.0 99212.0 76469.0 74686.0 87192.0 76535.0 99039.0 True False 83016.75873958619 73526.54671625636 78213.78172808791 78023.44297895902 86748.1015934666 87001.9106335322 78159.04698750144 87445.71428458726 91844.13856657324 96179.486735775 0.8631441231086047 0.7644722301154406 0.8132064786637653 0.811227483395764 0.9019397434692247 0.9045786537886659 0.8126373891162525 0.9091929812935972 0.9549243989925641 1.0 16.553441606805613 -7.938937766968374 0.32892488059920566 1.016219297502148 0.7918884147757199 0.6605976897349616 0.040736052028515254 0.865929285648773 0.31288164402760277 0.06956190879164341 0.06258032554124958 1.150965306832026e-08 7.938937766968374 -0.2243308827264281 KPSPQPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 KPSPQPSSPR 10 1 G3V5E1;O75909-1;O75909;O75909-4 G3V5E1 CCNK Cyclin-K 1 KPS(0.001)PQPS(0.055)S(0.944)PR;KPSPQPS(0.05)S(0.95)PR;KPS(0.001)PQPS(0.208)S(0.791)PR;KPSPQPS(0.112)S(0.887)PR 97.779 0.023406 309466600.0 20442.3 24113.2 26363.0 26799.9 26936.0 23182.7 21952.5 22471.9 14031.0 18612.0 True False 20918.56581620847 21290.01533407744 22783.049401593318 22119.80056142874 24499.643555937044 22949.503086207467 20296.605250940855 21875.872212981478 23809.58221630594 21001.03149623239 0.9960732557332379 1.0137604592372949 1.0848538275694042 1.0532721007250077 1.1665923914419303 1.0927798041884103 0.9664575406489957 1.0416570356035149 1.1337339416198393 1.0 14.358172569248115 -5.150679463876461 4.546950703621187 1.069163888384837 1.0003009012214956 0.1698407037898778 0.05556347206144177 0.40012479945380397 13.099178316400868 0.014918542645581992 0.043547108251948505 7.068390526229887e-06 5.150679463876461 -0.06886298716334127 KPSPQPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 KPSPQPSSPR 10 1 G3V5E1;O75909-1;O75909;O75909-4 G3V5E1 CCNK Cyclin-K 1 KPS(0.005)PQPS(0.301)S(0.694)PR;KPSPQPS(0.033)S(0.967)PR;KPSPQPS(0.011)S(0.989)PR 124.48 0.006871899999999999 35265000.0 129392.0 109275.0 119883.0 127664.0 146283.0 94911.0 106481.0 128515.0 93340.0 128571.0 True False 122200.91063721574 117656.04112549494 112169.85829874124 110275.94296731628 127905.62175338746 107984.12873372437 111432.5774880987 128888.95737319645 112010.60813750535 124858.82116242379 0.9787126732379566 0.9423126057905109 0.8983735170206677 0.8832050626512225 1.024401965056199 0.8648498178054411 0.892468601342476 1.0322775449363728 0.8970980752076402 1.0 16.929938224399166 -9.497044223139934 0.5568341435971575 1.004406322611532 0.930874219284948 0.09849612806643337 0.056515634933147034 9.796885031268863 3.7018503801528055 0.1650324144564759 0.0249737577234426 3.1838732992244403e-10 9.497044223139934 -0.07353210332658411 KPSPS(ph)ESPEPWKPFPAVSPEPR ddPTM_A459_Selumetinib_30min_R2 1 KPSPSESPEPWKPFPAVSPEPR 22 2 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPS(0.167)PS(0.541)ES(0.292)PEPWKPFPAVSPEPR 56.947 0.0087338 13400000.0 11838.0 10024.0 18047.0 18306.0 19889.0 12537.0 12267.0 9731.6 8644.7 14381.0 True False 11180.0913512687 10792.80856775989 16885.8756680879 15812.69122038861 17390.366010084046 14263.857950445174 12837.439806599368 9759.917344846892 10373.881553099314 13965.783163674694 0.8005345078211125 0.7728036760467698 1.2090890621879646 1.132245219266884 1.2452123741486096 1.0213432203033037 0.9192065819831593 0.6988449720623365 0.7428070041988054 1.0 13.769608857905526 -7.4800963816304575 3.4969312739095497 0.7911710309205124 1.039768642327513 0.25771024603900805 0.16246746467252837 0.32237433984615343 8.046917883514409 0.08504589368435951 0.05117799699375837 3.3105764273123335e-08 7.4800963816304575 0.24859761140700054 KPSPSES(ph)PEPWKPFPAVSPEPR ddPTM_A459_Selumetinib_30min_R2 2 KPSPSESPEPWKPFPAVSPEPR 22 2 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPS(0.042)PS(0.079)ES(0.879)PEPWKPFPAVS(0.001)PEPR;KPS(0.03)PS(0.188)ES(0.682)PEPWKPFPAVS(0.1)PEPR 66.44800000000001 0.0024861 8208400.0 36526.0 37143.0 36272.0 40163.0 36840.0 29983.0 28622.0 33154.0 26462.0 36427.0 True False 34496.03114516307 39991.74866643113 33938.29900996758 34692.73011496054 32211.829846221328 34112.88609142519 29952.97971341704 33250.47265105985 31755.139410056363 35375.25786128768 0.9751457156984634 1.1305005555929932 0.9593795511836364 0.9807060700729463 0.9105751249228857 0.9643148390659805 0.8467211696623582 0.9399358382471875 0.8976652420336719 1.0 15.11045304378641 -5.681250077564774 1.7303978230780397 0.9228133549411179 1.0506970830337237 0.3922584428515672 0.055622882606516794 0.3206683489204269 1.932529874493038 0.016166619904248315 0.037540041510899805 2.0832909269152656e-06 5.681250077564774 0.12788372809260573 KPSPSESPEPWKPFPAVS(ph)PEPR ddPTM_A459_Selumetinib_30min_R2 1 KPSPSESPEPWKPFPAVSPEPR 22 2 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KPSPSESPEPWKPFPAVS(1)PEPR 59.154 0.0069478000000000005 2306800.0 8305.9 6178.7 9051.2 8950.3 8458.6 8561.4 7628.1 8241.1 5807.2 9982.8 True False 7844.291329152115 6652.586422348171 8468.855646201431 7731.253699871308 7395.95504715656 9740.655137348755 7982.821764793393 8265.080236612452 6968.802266725087 9694.570625570668 0.8091427286590491 0.6862177479837142 0.8735668626585423 0.7974828384332091 0.762896608092037 1.0047536413481308 0.8234322151140641 0.8525473232215408 0.7188355767241492 1.0 13.242961287163562 -5.694938416471117 0.9978300377422045 0.8589378913021756 0.7522268626756909 0.14131810836556613 0.0930493936767592 1.4298752713447458 2.5975739842343732 0.035659252984772516 0.11973390923101172 2.0186525909804788e-06 5.694938416471117 -0.10671102862648463 KPSVGVPPPAS(ph)PSYPR ddPTM_A459_Selumetinib_30min_R1 2 KPSVGVPPPASPSYPR 16 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 KPSVGVPPPAS(0.5)PS(0.5)YPR;KPSVGVPPPAS(0.958)PS(0.041)Y(0.001)PR 104.38 0.0020004000000000003 164036000.0 6195.200000000001 8016.9 8504.4 9403.9 8603.4 7341.0 7875.400000000001 7139.799999999999 3738.9 6086.1 True False 6339.536106239256 7078.277621044302 7349.549191325348 7761.685398065661 7825.223989053643 7267.156205094705 7281.352237479081 6950.429310661093 6344.6402215484495 6867.310218634212 0.9231468951318291 1.0307205289543548 1.070222395281139 1.1302366066126723 1.1394889323362973 1.0582245411566706 1.060291730774209 1.0121035877775464 0.9238901432372292 1.0 12.745529420954337 -10.199668673517827 5.492273740655559 0.9999999975432753 1.0454783649040302 0.01906828546848305 0.06935161699001602 2.319865240291048e-09 3.9165526087245536e-10 0.07217819291255106 0.017505782219040877 6.314388901832601e-11 10.199668673517827 0.045478367360754945 KPSVGVPPPAS(ph)PSYPR ddPTM_A459_Selumetinib_30min_R2 2 KPSVGVPPPASPSYPR 16 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 KPSVGVPPPAS(0.757)PS(0.242)Y(0.001)PR;KPSVGVPPPAS(0.839)PS(0.159)Y(0.002)PR 107.57 0.0016918 135131000.0 114065.0 110493.0 131402.0 119941.0 139255.0 90830.0 98741.0 100149.0 91888.0 114322.0 True False 107725.72393837337 118967.45780900765 122947.73837968045 103604.82889023413 121760.54194450458 103341.00802735394 103332.65215157958 100440.4170094406 110268.16756523511 111021.22681577213 0.9703164613478169 1.0715739793293895 1.1074255068690522 0.9331983789204139 1.0967320884190301 0.9308220688178604 0.930746805050615 0.9046956144351633 0.9932169795620559 1.0 16.760476014922872 -6.781078825904439 24.997972329257482 0.9446179007344215 1.0361076248316505 0.3492041302296295 0.05687160914643351 253.9529484038484 323240.50863803696 0.019431741167382326 0.017160546817663682 1.655469462941936e-07 6.781078825904439 0.091489724097229 KPSVSEEVQAT(ph)PNK ddPTM_A459_Selumetinib_30min_R1 1 KPSVSEEVQATPNK 14 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 KPS(0.045)VSEEVQAT(0.955)PNK 163.66 0.034036000000000004 14301000.0 5085.0 5101.2 5952.2 6435.1 5402.0 4367.9 5959.5 5997.3 4263.4 4564.6 True False 5203.4706063124 4503.949132516458 5143.923933094249 5311.330586787641 4913.390053800562 4323.962891735886 5509.970116979021 5838.2321220241165 7234.67841358411 5150.510872969183 1.0102824233652548 0.8744664837334878 0.9987211094127568 1.0312240315154888 0.9539616894290867 0.8395211656437479 1.069790988287462 1.1335248611286737 1.4046525853489635 1.0 12.330499823238565 -7.675891917622893 2.7570545764624823 1.2116356290156658 0.9542499759712052 0.46513523987429406 0.10876215016683416 0.21511306787641205 3.2801147740923824 0.06047830937970501 0.029510929147830208 2.1091529871440463e-08 7.675891917622893 -0.2573856530444606 KPTAEAS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 KPTAEASPVK 10 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 KPT(0.001)AEAS(0.999)PVK;KPT(0.002)AEAS(0.998)PVK 65.956 0.044757 28991000.0 114699.0 97090.0 99123.0 111486.0 105850.0 84311.0 94843.0 94479.0 76373.0 105058.0 True False 108324.48875647657 104536.49080644514 92745.53409696234 96301.41447592294 92552.17668899377 95924.07495094379 99253.38742783916 94753.9182481595 91649.73403991501 102024.70256653451 1.0617476555330676 1.0246194125219095 0.909049786609073 0.943902918149855 0.9071545847304645 0.9402044067551949 0.9728368221716887 0.9287350598877421 0.8983092499597972 1.0 16.638558979138082 -5.121242475318599 4.161080751463978 0.9356600591045097 1.0544000202311328 0.6762234573046653 0.02962029705781242 0.11778978848463242 3.3353692122941228 0.007398908521707376 0.022746387753044262 7.564104579766482e-06 5.121242475318599 0.1187399611266231 KPTGSLPS(ph)PSGVR ddPTM_A459_Selumetinib_30min_R2 2 KPTGSLPSPSGVR 13 1 G3V538;F8W717;A0A3B3IU69;O00423-3;G3V497;G3V4H6;G3V500;G3V3N9;O00423 G3V538 EML1 Echinoderm microtubule-associated protein-like 1 1 KPTGS(0.001)LPS(0.82)PS(0.179)GVR;KPTGSLPS(0.792)PS(0.208)GVR 69.485 0.032723 118706000.0 96473.0 72183.0 117201.0 95154.0 130394.0 86796.0 60219.0 88534.0 83981.0 92028.0 True False 91111.41687201764 77719.20399507301 109660.41525880019 82193.8610501942 114012.73998284982 98751.36114435973 63019.30282168476 88791.61928240726 100779.54662519637 89370.91252254066 1.0194750652124984 0.8696252706994693 1.227025798031795 0.9196936534519965 1.2757253648282278 1.1049608687776706 0.7051433295569223 0.9935181008699302 1.1276548910673625 1.0 16.4475177345845 KPVAGALDVS(ph)FNK ddPTM_A459_Selumetinib_30min_R1 1 KPVAGALDVSFNK 13 1 H7C3S9;E9PGT6;Q99627-2;Q99627 H7C3S9 COPS8 COP9 signalosome complex subunit 8 1 KPVAGALDVS(1)FNK 94.01 0.008394200000000001 11538000.0 2678.1 3019.7 3174.3 2913.2 2870.5 2615.3 2777.4 3081.3 1857.0 2123.9 True False 2740.494519324532 2666.1521201795545 2743.247495181797 2404.464307536752 2610.863781827937 2588.992456502406 2567.898481902431 2999.573914527023 3151.1933700862473 2396.523253537933 1.1435292836315283 1.1125083456810085 1.1446780210173229 1.003313572687891 1.0894381174785506 1.0803118445357602 1.071509937619633 1.251635639294891 1.3149020629923835 1.0 11.226727223200687 -7.755756262720112 24.999017898702192 1.2124516463209878 1.0910045007828495 0.20067946730824504 0.0845315491719306 163.67439956520957 719983.9225000616 0.039340435038487345 0.021913879579228905 1.7548651011427866e-08 7.755756262720112 -0.12144714553813829 KPVTVSPT(ph)TPTSPTEGEAS ddPTM_A459_Selumetinib_30min_R2 1 KPVTVSPTTPTSPTEGEAS 19 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 KPVT(0.003)VS(0.129)PT(0.858)T(0.009)PTSPTEGEAS 128.82 0.040935 28235000.0 33308.0 35679.0 34909.0 36186.0 39864.0 28688.0 30382.0 32539.0 28356.0 35415.0 True False 31456.87470248842 38415.4645739331 32662.99294604539 31257.40437566823 34855.92793131833 32639.511596264754 31794.82320079089 32633.683102878575 34027.99233283797 34392.47693077945 0.9146440591005001 1.1169728964636825 0.9497133053773669 0.9088442347022265 1.0134753597849802 0.9490305586875052 0.924470292290469 0.9488610886781799 0.9894021998277395 1.0 15.069805401406294 KPVTVSPTT(ph)PTSPTEGEAS ddPTM_A459_Selumetinib_30min_R2 1 KPVTVSPTTPTSPTEGEAS 19 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 KPVTVS(0.001)PT(0.005)T(0.96)PT(0.029)S(0.004)PT(0.001)EGEAS 135.57 0.023973 38094000.0 27311.0 24845.0 27713.0 31471.0 31682.0 20398.0 22539.0 23445.0 24752.0 29224.0 True False 25793.16395459534 26750.531610733684 25929.97575163298 27184.595509496892 27701.823919326376 23207.639345392083 23587.108160181222 23513.221068471314 29703.091628664297 28380.22718692922 0.9088427581888641 0.9425763731396024 0.9136634312629912 0.9578709617242603 0.9760959183612424 0.8177397309941401 0.8311106181364357 0.8285071473740897 1.0466121864713027 1.0 14.79259851793115 -3.3161611241594677 15.58721335477132 0.9149061544046508 0.40677217540842603 0.0 0.07410084184007189 0.0 0.0 0.01720707290285993 0.0 0.00048287961945634 3.3161611241594677 -0.5081339789962248 KPVTVSPTTPTS(ph)PTEGEAS ddPTM_A459_Selumetinib_30min_R1 4 KPVTVSPTTPTSPTEGEAS 19 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 KPVTVSPTTPT(0.187)S(0.654)PT(0.098)EGEAS(0.06);KPVTVSPTT(0.002)PT(0.16)S(0.755)PT(0.052)EGEAS(0.031);KPVTVSPT(0.004)T(0.037)PT(0.436)S(0.457)PT(0.017)EGEAS(0.048);KPVTVSPTT(0.004)PT(0.029)S(0.965)PT(0.001)EGEAS 99.238 0.00248 154309000.0 12863.6 14647.7 17167.5 17255.8 15457.2 13019.9 15667.099999999999 15676.100000000002 7663.699999999999 11578.8 True False 13163.296851791587 12932.740474469021 14836.247794327395 14242.39846148314 14059.098989190312 12888.931627123342 14485.318033345426 15260.318904850887 13004.739165498091 13065.051767062958 1.0075196858367073 0.9898728841681673 1.1355674710550807 1.0901142004954223 1.0760844457297407 0.9865197518479325 1.1087072819614052 1.168025904292412 0.9953836691472655 1.0 13.673425220543935 -5.233063137038471 24.8054973229869 1.075380709386786 0.9986962534644397 0.1904208380742538 0.058023758129421656 1000.840270940506 874894.673086616 0.014613568789172316 0.03865034389750242 5.847050744750422e-06 5.233063137038471 -0.0766844559223463 KPVTVSPTTPTS(ph)PTEGEAS ddPTM_A459_Selumetinib_30min_R2 2 KPVTVSPTTPTSPTEGEAS 19 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 KPVTVSPTT(0.001)PT(0.013)S(0.985)PT(0.001)EGEAS;KPVTVS(0.001)PT(0.009)T(0.023)PT(0.385)S(0.544)PT(0.016)EGEAS(0.023) 93.181 0.0037475 161366000.0 80354.0 82209.0 93727.0 91314.0 97651.0 64965.0 81221.0 79041.0 71242.0 101687.0 True False 75888.2463625481 88514.16595640183 87696.70686224151 78876.87567456395 85383.20836898367 73913.33905644651 84997.93743635835 79270.9962240581 85492.39066779667 98751.03209544445 0.7684805389092126 0.8963366162173524 0.8880586359591791 0.7987448232270443 0.8646310479718272 0.7484816866015951 0.8607296109493467 0.8027358756862553 0.8657366799484881 1.0 16.591508206118434 -8.621864981407198 5.9883744738824305 0.9999986835643915 0.8314873926709352 0.543745688329874 0.047031587103322246 1.0911226955810576 65.67531904253232 0.0441547894799828 0.011444380384527095 2.3885537492661166e-09 8.621864981407198 -0.1685112908934563 KQALYLMFDTSQES(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 KQALYLMFDTSQESPVK 17 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 KQALYLMFDTS(0.008)QES(0.992)PVK;KQALYLMFDTS(0.005)QES(0.995)PVK 146.97 0.00020916 60065000.0 19044.0 19051.3 21981.6 23362.7 19744.3 17474.8 18423.1 18000.5 10954.8 16699.6 True False 19487.68814682663 16820.764939290926 18996.61945628584 19282.843017193773 17958.43155113929 17299.01937784892 17033.430734477104 17523.06826613561 18589.495493064518 18843.15632787894 1.0342050879233056 0.8926723658500973 1.008144236864386 1.0233340254500942 0.95304795219309 0.918053168844891 0.9039584684268474 0.9299433683628563 0.9865383043901661 1.0 14.201753023755959 -6.506516768137009 23.42053347772387 0.940026822463653 0.9845166161071728 0.15080075382917002 0.04540364512392939 570.4008562709593 816473.3819732225 0.014267648100655363 0.015722588295973505 3.115180616334056e-07 6.506516768137009 0.04448979364351979 KQAMS(ph)IR ddPTM_A459_Selumetinib_30min_R1 1 KQAMSIR 7 1 M0R036 M0R036 1 KQAMS(1)IR 69.812 0.035247 3716800.0 2310.9 2762.6 1902.7 2019.8 2515.8 1785.8 2587.8 2383.5 1418.6 2550.6 True False 2364.7394737713535 2439.1535077021035 1644.3237907829766 1667.0798463417316 2288.246334200566 1767.8364733766684 2392.6001625502663 2320.2818373008663 2407.260589555384 2877.994354947902 0.8216623044120461 0.8475185170216422 0.571343646993617 0.5792505615848955 0.7950836770289593 0.6142598821771039 0.8313428962905584 0.806214867416885 0.8364368698002399 1.0 11.490848046963837 -8.39217303155515 0.8058687733316782 0.9936926411731765 0.7058062928614837 0.44878944561800116 0.09731269675468684 0.6085314582277842 0.885344011151971 0.0988241895525308 0.03711916369421943 4.053470049671667e-09 8.39217303155515 -0.2878863483116928 KQDDS(ph)PPRPIIGPALPPGFIK ddPTM_A459_Selumetinib_30min_R1 2 KQDDSPPRPIIGPALPPGFIK 21 2 A0A0A0MRI1;Q8IXQ4-4;Q8IXQ4 A0A0A0MRI1 GPALPP1 GPALPP motifs-containing protein 1 1 KQDDS(1)PPRPIIGPALPPGFIK;KQDDS(1)PPRPIIGPALPPGFIK 72.932 0.0025156 47158000.0 15417.5 16664.5 20138.9 20065.5 16086.8 15118.0 15542.6 14637.4 9444.2 12387.3 True False 15776.69775276725 14713.412592884139 17404.147995059284 16561.43710108427 14631.751780355215 14965.926646045735 14370.209168580954 14249.168603023989 16026.11762292328 13977.330617519854 1.1287346764905155 1.0526625573585306 1.2451696587361318 1.184878397333277 1.0468201819605725 1.070728528613806 1.0281082677237845 1.0194484907700043 1.14657927621998 1.0 13.770801241508591 -6.2711905096293545 24.500996392436566 1.0526669700154596 1.1522977204702738 0.41939395092001786 0.05816306000927205 539.3049205320461 1355072.6012256239 0.01845970853552182 0.021213729014688522 5.355616740126562e-07 6.2711905096293545 0.09963075045481418 KQDDS(ph)PPRPIIGPALPPGFIK ddPTM_A459_Selumetinib_30min_R2 1 KQDDSPPRPIIGPALPPGFIK 21 2 A0A0A0MRI1;Q8IXQ4-4;Q8IXQ4 A0A0A0MRI1 GPALPP1 GPALPP motifs-containing protein 1 1 KQDDS(1)PPRPIIGPALPPGFIK 57.692 0.010522 12681000.0 80063.0 66286.0 81578.0 81085.0 85451.0 62934.0 62181.0 54052.0 44184.0 78151.0 True False 75613.41897758297 71369.92305691646 76329.36029541072 70041.0831205731 74715.8814383675 71602.58724202887 65072.53970931397 54209.28237120969 53022.03460410887 75894.57756931643 0.9962954060653849 0.9403823743762526 1.0057287719362715 0.9228733509532062 0.9844692971658957 0.9434479976732516 0.8574069688955258 0.7142708228621337 0.6986274422001033 1.0 16.211709192814546 -7.388784785068294 2.914438790700313 0.7804386775460677 0.9664212646564151 0.4435978770273148 0.08105731198410135 0.212271455859434 3.4602768027431736 0.03681197286166567 0.022835208113544933 4.085217794316518e-08 7.388784785068294 0.18598258711034743 KQDLSSS(ph)LTDDSK ddPTM_A459_Selumetinib_30min_R1 1 KQDLSSSLTDDSK 13 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 KQDLS(0.23)S(0.23)S(0.541)LTDDSK 147.7 0.0010171 3673000.0 1074.0 1241.5 1237.1 1281.0 1178.9 1234.5 1021.4 1423.9 785.93 1107.8 True False 1099.0221103597878 1096.1446028423081 1069.1086149038845 1057.2973973481328 1072.2687031517 1222.0820508363179 944.3549756661423 1386.1335465209581 1333.6658079439328 1249.9969208857867 0.8792198540625097 0.8769178423780004 0.8552889987491176 0.8458400014288827 0.8578170755747598 0.9776680489503227 0.7554858415146679 1.1089095687841382 1.066935274527601 1.0 10.287708825766828 -7.774088286615953 24.999997578205907 1.0659418746915814 0.8676248009499768 0.7135097197423128 0.056412774800353616 116.26495980685539 229788.99577164266 0.02883220192175373 0.013997231458988993 1.6823320293250288e-08 7.774088286615953 -0.19831707374160457 KQDLSSS(ph)LTDDSK ddPTM_A459_Selumetinib_30min_R2 1 KQDLSSSLTDDSK 13 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 KQDLS(0.001)S(0.037)S(0.868)LT(0.091)DDS(0.002)K 73.252 0.026906 10666000.0 41137.0 32739.0 44030.0 49000.0 45957.0 31447.0 40209.0 40961.0 26366.0 41913.0 True False 38850.77022445855 35249.97602752306 41197.1577362393 42326.11547028524 40183.47079920722 35778.53880255638 42078.79817262196 41080.1897285414 31639.936727592234 40702.8627869479 0.9544972408406798 0.8660318614941893 1.0121439848562668 1.0398805531648712 0.9872394236626709 0.8790177484525586 1.0338043884744952 1.0092702801660058 0.7773393457164429 1.0 15.312842647831774 -9.881071568349535 11.694705717308842 0.9999989707068851 0.9560312564928117 0.02845619879798833 0.0812406732724326 0.0 0.0 0.07807476473155966 0.018935911863733473 1.3150081112366753e-10 9.881071568349535 -0.04396771421407342 KQDLSSSLT(ph)DDSK ddPTM_A459_Selumetinib_30min_R2 1 KQDLSSSLTDDSK 13 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 KQDLS(0.004)S(0.01)S(0.237)LT(0.737)DDS(0.012)K 90.498 0.026264 12216000.0 48463.0 41573.0 46240.0 46819.0 45794.0 32459.0 40499.0 41563.0 28145.0 39833.0 True False 45769.62047276021 44761.51542173602 43264.96874230539 40442.17143272011 40040.948316445676 36929.93261653506 42382.283747246045 41683.941448874946 33774.78643700535 38682.91779143689 1.183199796859483 1.1571390675096573 1.1184515339709666 1.0454788248075915 1.0351067241703624 0.95468322259574 1.0956330640763627 1.0775800748438469 0.8731188949888874 1.0 15.23940899867845 -5.633610987042808 1.288618608789903 1.0097408918104975 1.1845021652092003 0.5691786027858399 0.058597668761466125 0.3968887136861873 1.2536070837759044 0.01990394812322561 0.060765190880439204 2.3248182861074874e-06 5.633610987042808 0.17476127339870273 KQEAESWS(ph)PDACLGVK ddPTM_A459_Selumetinib_30min_R1 1 KQEAESWSPDACLGVK 16 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;A0A0A0MSJ3;Q3HKR1 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 KQEAES(0.025)WS(0.975)PDACLGVK 80.156 0.012099 9075700.0 2058.8 2338.2 2892.9 2677.1 2247.5 1898.6 2563.6 2013.6 1486.8 1791.1 True False 2106.7660342725612 2064.4424570003102 2500.0600695622393 2209.594740390856 2044.2140218283528 1879.5018077908733 2370.2255880337984 1960.1927869053998 2522.9910084244634 2021.0051317914174 1.0424347771967928 1.0214929316732562 1.2370379620689969 1.0933147598849848 1.0114838352816864 0.9299836889206137 1.1727954327027523 0.969909851326249 1.24838426619337 1.0 10.98085726971503 -3.509657909213919 10.395013191165319 1.072681416044414 1.077126483422432 0.0 0.10574526232662126 0.0 0.0 0.023386430450587206 0.0 0.0003092730595995081 3.509657909213919 0.004445067378017864 KQEGPATQVDSAVGTLPAT(ph)SPQSTSVQAK ddPTM_A459_Selumetinib_30min_R1 1 KQEGPATQVDSAVGTLPATSPQSTSVQAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06 E7ETY2 TCOF1 Treacle protein 1 KQEGPATQVDSAVGTLPAT(0.5)S(0.5)PQSTSVQAK 180.09 7.2684e-28 87036000.0 5341.3 5647.4 5832.1 6315.2 5247.7 5019.7 5159.9 5302.7 2987.7 4100.2 True False 5465.741897639418 4986.199782594965 5040.132853432173 5212.368870985891 4773.046461556686 4969.2063755229365 4770.684588740677 5162.055170402894 5069.9086870256715 4626.500609330114 1.1813987199346379 1.077747568548777 1.089404990732715 1.1266331318479188 1.031675312423182 1.0740745101171498 1.0311648028576486 1.1157580223793215 1.0958409206304547 1.0 12.175705665535109 KQEGPATQVDSAVGTLPAT(ph)SPQSTSVQAK ddPTM_A459_Selumetinib_30min_R2 1 KQEGPATQVDSAVGTLPATSPQSTSVQAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06 E7ETY2 TCOF1 Treacle protein 1 KQEGPATQVDSAVGTLPAT(0.406)S(0.406)PQS(0.051)T(0.069)S(0.069)VQAK 71.097 0.00033935 115460000.0 52620.0 48440.0 47023.0 51110.0 51845.0 45982.0 44595.0 50731.0 39791.0 59496.0 True False 49695.59105454969 52155.192240850876 43997.591374771306 44148.72983033224 45331.767599819315 52315.60311696336 46668.75586331611 50878.618811030836 47750.31185343331 57778.1958908275 0.8601097747747268 0.9026794872480729 0.7614912632077542 0.7641071021627557 0.7845826076929463 0.9054558092435809 0.8077226217221668 0.8805851070041459 0.8264417245505211 1.0 15.818237536377012 -10.23886223506062 0.45875299650865137 1.0450339097448196 0.8237450553865272 0.4965168838747188 0.05078063205153518 10.620009338559917 1.7507852500008732 0.751334238757385 0.029274175979194256 5.7694945167369335e-11 10.23886223506062 -0.22128885435829238 KQEGPATQVDSAVGTLPATS(ph)PQSTSVQAK ddPTM_A459_Selumetinib_30min_R1 1 KQEGPATQVDSAVGTLPATSPQSTSVQAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06 E7ETY2 TCOF1 Treacle protein 1 KQEGPATQVDSAVGT(0.03)LPAT(0.345)S(0.623)PQS(0.001)T(0.001)SVQAK 144.57 3.0165e-15 88108000.0 5408.6 5632.4 6565.0 6604.3 5960.2 5021.9 5325.4 4965.3 2922.9 4871.0 True False 5534.609856696412 4972.955989568277 5673.509058963707 5450.982983065011 5421.100962358773 4971.384245520373 4923.700790495864 4833.604114432553 4959.947819830417 5496.240297557923 1.0069810556055085 0.90479231626351 1.0322527312869758 0.9917657685903906 0.9863289574088426 0.9045063491363808 0.8958306995208253 0.8794382801239983 0.9024255766317585 1.0 12.424229365331318 -6.761509894085738 24.999951873254442 0.9076169716035927 0.9830651917401814 0.37355440829862685 0.043253420937478054 1.8463284053684406 654273.2792724216 0.014262671679167426 0.013391363561058132 1.7317695771706495e-07 6.761509894085738 0.0754482201365887 KQEGPATQVDSAVGTLPATS(ph)PQSTSVQAK ddPTM_A459_Selumetinib_30min_R2 4 KQEGPATQVDSAVGTLPATSPQSTSVQAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06 E7ETY2 TCOF1 Treacle protein 1 KQEGPATQVDSAVGT(0.004)LPAT(0.236)S(0.7)PQS(0.021)T(0.029)S(0.009)VQAK;KQEGPATQVDSAVGTLPAT(0.109)S(0.881)PQS(0.005)T(0.003)S(0.002)VQAK;KQEGPATQVDSAVGTLPAT(0.1)S(0.888)PQS(0.002)T(0.008)S(0.003)VQAK;KQEGPATQVDSAVGT(0.037)LPAT(0.417)S(0.493)PQS(0.023)T(0.017)S(0.012)VQAK 173.46 4.0483e-24 198075400.0 459365.0 436456.0 516817.0 573446.0 558328.0 418971.0 449339.0 450169.0 393844.0 526522.0 True False 433835.3322837938 469930.7717727674 483565.55688780296 495341.66555047437 488185.8451243504 476680.45220993605 470234.1538483373 451478.9172605107 472623.8049208014 511319.94179155404 0.8484615928800449 0.9190542620462485 0.9457201203487082 0.9687509229835721 0.9547561227787307 0.9322547650689141 0.9196475932480531 0.8829675519374945 0.9243210880155197 1.0 18.963866767550954 -4.775592418627397 3.1305214922341356 0.9371432136870016 0.8343429027941976 0.4645289500620454 0.029620282322878475 0.35660151954747527 5.178461267690266 0.007931607350851376 0.09234152517687441 1.6765155323402556e-05 4.775592418627397 -0.10280031089280395 KQELEEICHDLEAR ddPTM_A459_Selumetinib_30min_R1 4 KQELEEICHDLEAR 14 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;;; 148.57 0.00030825 72817000.0 29225.9 31997.9 35515.6 37157.6 34782.8 28348.5 29108.1 29452.0 16874.6 24583.4 False True 29906.806606298083 28251.570992579862 30692.776593226394 30668.722694537857 31636.70188140212 28063.339828378583 26912.452581934253 28670.837286421272 28634.963727979182 27738.91885259401 1.0781532894351196 1.0184813309671552 1.1064878467805226 1.1056206933483228 1.1405167609278906 1.0116955162350978 0.9702055341431423 1.0335960618645421 1.0323028045954783 1.0 14.75962393806903 -6.831955815788114 11.044153936906568 1.0090587732028597 1.0876584456697282 0.5920979506481199 0.033296606267422535 0.40570440370641514 61.529049407943944 0.012706010474343775 0.011209095287481194 1.4724623000460183e-07 6.831955815788114 0.0785996724668685 KQETAAVCGET(ph)DEEAGESGGEGIFR ddPTM_A459_Selumetinib_30min_R2 2 KQETAAVCGETDEEAGESGGEGIFR 25 1 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 KQETAAVCGET(0.991)DEEAGES(0.009)GGEGIFR;KQETAAVCGET(0.997)DEEAGES(0.003)GGEGIFR 81.803 0.00020491 7722200.0 33029.9 27166.6 32797.7 39249.0 37321.0 29828.8 32331.4 33452.4 33852.6 24774.9 True False 31194.230387165902 29250.190865613135 30687.53168943576 33903.21849169849 32632.402326026782 33937.4464411134 33834.8741634537 33549.740945657046 40624.06592067393 24059.5842640793 1.2965407068042547 1.2157396630200028 1.2754805466548278 1.4091356741486023 1.3563161344706445 1.410558306769317 1.4062950461687238 1.3944439179585677 1.688477468055224 1.0 14.55432409332973 -5.712041668597262 5.025430171995952 1.3986825765733126 1.2545019950561698 0.09846295980347353 0.15763628825963819 0.3781364531232576 20.54889727910925 0.04096060568535008 0.07082033623463903 1.9406996672776312e-06 5.712041668597262 -0.14418058151714286 KQFS(ph)LENVQEGEILHDAK ddPTM_A459_Selumetinib_30min_R2 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 KQFS(1)LENVQEGEILHDAK 72.187 0.013943 3499700.0 17697.0 14088.0 19508.0 17192.0 18081.0 11044.0 13557.0 14510.0 9480.1 13660.0 True False 16713.471586704014 15168.50429994028 18252.87651870444 14850.419942145807 15809.503133809123 12565.210752549763 14187.427362685872 14552.22169774018 11376.384896125584 13265.600307057677 1.2599106862741802 1.1434465044050968 1.3759555614677603 1.1194683691958487 1.1917668833575528 0.9472025737022027 1.0694900369595606 1.0969893077509643 0.8575853811962828 1.0 13.695402342746586 -6.519914217299797 1.7192581915342326 1.0030687625591244 1.2386447864928014 0.5883439656668521 0.091881760159286 0.263329160799434 1.5764654099913131 0.03431545654185779 0.03758867744519009 3.0205482861207207e-07 6.519914217299797 0.23557602393367705 KQGGS(ph)PDEPDSK ddPTM_A459_Selumetinib_30min_R1 1 KQGGSPDEPDSK 12 1 V9GZ50;Q9ULX6;Q9ULX6-2 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 KQGGS(0.826)PDEPDS(0.174)K 120.29 0.0073063999999999985 2277000.0 855.97 2087.3 1735.2 1259.5 931.7 1314.0 704.66 1186.3 2285.5 1342.1 True False 875.9124355723158 1842.9179456405566 1499.5693707713356 1039.551968743149 847.4278995049949 1300.7823530165424 651.5069288749793 1154.8354703545274 3878.3265736845 1514.3716081610528 0.5783999322570256 1.2169522564401927 0.9902254920060922 0.6864576456273559 0.5595904564891124 0.8589584920943689 0.4302160218561703 0.7625839418350421 2.561013791320394 1.0 10.564503553042162 -8.225381780502426 24.33683820601901 1.7805067540795565 0.7664182162577803 0.4980612719410463 0.40958337038157444 281.3583112182285 189901.44045848277 0.25922596437062084 0.09796988960912388 5.951387376968043e-09 8.225381780502426 -1.014088537821776 KQGGS(ph)PDEPDSK ddPTM_A459_Selumetinib_30min_R2 2 KQGGSPDEPDSK 12 1 V9GZ50;Q9ULX6;Q9ULX6-2 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 KQGGS(0.999)PDEPDS(0.001)K;KQGGS(1)PDEPDSK 88.311 0.014027 7829200.0 29614.0 25939.0 26508.0 21362.0 22585.0 29951.0 70621.0 189922.0 40126.0 96535.0 True False 27968.172434234777 27928.43789296926 24802.504139728182 18452.45874849457 19747.670387538245 34076.47838189226 73905.01643285673 190474.64157672043 48152.32121411535 93747.78372194822 0.298334225342192 0.2979103802155342 0.2645662985835624 0.19683087979150254 0.21064679722039042 0.36349102911020903 0.7883388118492033 2.0317775419807234 0.5136369021472871 1.0 16.51649696389974 -7.411270612728634 3.6315505858370356 1.2334398235682318 0.26704345330086177 0.5663496150511437 0.3557022581725594 0.15591051788347624 3.7256799814929806 0.1514044411797401 0.0959393407073598 3.8790858140519796e-08 7.411270612728634 -0.96639637026737 KQISGQYSGS(ph)PQLLK ddPTM_A459_Selumetinib_30min_R2 2 KQISGQYSGSPQLLK 15 1 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 KQISGQY(0.001)S(0.122)GS(0.877)PQLLK;KQISGQYSGS(1)PQLLK 108.12 0.0020895 14669000.0 95516.0 93819.0 107641.0 113740.0 111613.0 68341.0 68031.0 65190.0 50930.0 75279.0 True False 90207.60310084315 101014.61562436797 100715.4952506596 98248.41578755614 97591.17710711989 77754.35241216987 71194.57630086903 65379.69210721456 61117.42310309763 73105.4996716688 1.2339373030207474 1.3817649298348893 1.3776733036911413 1.3439264655711147 1.3349361887330102 1.063591012459801 0.9738607440017221 0.8943197488676999 0.8360167617701543 1.0 16.15769232267091 -6.940185200649917 2.0153101714531583 0.9107633233916025 1.3463289765685582 0.9186081829709801 0.057696429682150316 0.0824105989185012 0.6792695720138385 0.02481172532287443 0.020112717982866686 1.1476641069547075e-07 6.940185200649917 0.4355656531769557 KQITTS(ph)PITVR ddPTM_A459_Selumetinib_30min_R2 1 KQITTSPITVR 11 1 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 KQIT(0.071)T(0.046)S(0.875)PIT(0.008)VR 68.168 0.037338 17582000.0 48796.0 60140.0 56547.0 57366.0 64339.0 42960.0 43751.0 40768.0 30278.0 61055.0 True False 46084.11366586482 64752.544619421395 52908.82758371848 49552.651838130274 56256.15962204216 48877.35004794801 45785.50819096184 40886.62813049427 36334.446038004935 59292.18351005902 0.7772375874477041 1.0920924274687238 0.8923406839072203 0.83573666720713 0.9487955459170805 0.8243472774055604 0.772201418137928 0.6895787220175115 0.6128033053773562 1.0 15.855554306335003 -7.067201653993532 2.3276898657703273 0.7399709753748073 0.9147726092157809 0.21739828157413266 0.12083354833695906 0.38451733241290353 4.119210655946112 0.050846127500567564 0.03839841082258948 8.566399930955661e-08 7.067201653993532 0.17480163384097358 KQNS(ph)PVAPTAQPK ddPTM_A459_Selumetinib_30min_R1 2 KQNSPVAPTAQPK 13 1 Q6P1N0;Q6P1N0-2 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 KQNS(0.938)PVAPT(0.062)AQPK;KQNS(0.63)PVAPT(0.37)AQPK 153.48 0.00073735 19058700.0 7152.1 8053.200000000001 7338.0 8429.0 6784.5 6739.6 6435.4 6352.5 3700.3 6156.1 True False 7318.730014435973 7110.32760016889 6341.53990474877 6957.033381926161 6170.843172900758 6671.805743067189 5949.972596829738 6184.011064171914 6279.138840780906 6946.295400491956 1.053616293645911 1.0236143426415925 0.9129384138053853 1.0015458572973222 0.8883646342572361 0.9604840218276167 0.8565677463714464 0.8902603053325295 0.9039550549975459 1.0 12.76202804922069 -4.531531617615025 0.6685240432094011 0.9103758469370332 1.2047060679115553 0.4700888299435684 0.0466148628955914 3.432175625652242 0.9192576381488277 0.019661313008326162 0.8289687846993309 2.940819587673718e-05 4.531531617615025 0.2943302209745221 KQNS(ph)PVAPTAQPK ddPTM_A459_Selumetinib_30min_R2 2 KQNSPVAPTAQPK 13 1 Q6P1N0;Q6P1N0-2 Q6P1N0 CC2D1A Coiled-coil and C2 domain-containing protein 1A 1 KQNS(0.535)PVAPT(0.465)AQPK;KQNS(1)PVAPTAQPK 140.93 0.0015366 59175700.0 267888.0 263978.0 292565.0 329286.0 305428.0 217002.0 252878.0 274215.0 220189.0 254383.0 True False 252999.85740063118 284224.263776947 273741.68642068695 284436.6787499665 267057.404079036 246892.05575197458 264637.328068251 275012.920251263 264232.95259469736 247038.30182359094 1.0241321104178305 1.1505271112975444 1.108094106865116 1.1513869576106526 1.081036430819301 0.9994080024411729 1.0712400713360937 1.1132400045708242 1.0696031774999208 1.0 17.914375214898705 -6.5184500812015775 24.98739325795234 1.0569665709424798 1.1120915950594779 0.2567235867417299 0.04567555173259736 278.39205462311503 1570758.5857860488 0.014861289681770041 0.01523071990248658 3.0307486389304413e-07 6.5184500812015775 0.055125024116998045 KQPPQIES(ph)FY(ph)PPLDEPS(ph)IGSK ddPTM_A459_Selumetinib_30min_R2 1 KQPPQIESFYPPLDEPSIGSK 21 1 O60934;A0A0C4DG07;E5RGR7 O60934 NBN Nibrin 3 KQPPQIES(1)FY(1)PPLDEPS(0.84)IGS(0.16)K 44.264 0.045049 3036700.0 4254.8 5555.3 16624.0 18650.0 27395.0 18065.0 6415.1 10754.0 16279.0 15081.0 True False 4018.3352493139105 5981.373646895103 15554.429938842657 16109.837826955512 23953.395185592643 20553.289772257485 6713.414861279493 10785.29235957946 19535.254873263828 14645.572344856273 0.27437201870264943 0.408408323420412 1.0620568163937674 1.0999800791406769 1.635538347124099 1.403379075142535 0.458392113548047 0.7364199981824133 1.333867629975204 1.0 13.838176953985656 -5.232405123688691 3.788647946558457 1.094315496210399 0.30398147616222826 0.4785459450870092 0.3144939183535328 0.2105870305413225 6.6458793112873735 0.09185333444596622 0.25893762310329516 5.855916511568115e-06 5.232405123688691 -0.7903340200481707 KQPPVS(ph)PGTALVGSQK ddPTM_A459_Selumetinib_30min_R1 2 KQPPVSPGTALVGSQK 16 1 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVS(0.923)PGT(0.077)ALVGSQK;KQPPVS(0.896)PGT(0.104)ALVGSQK 116.94 0.00096562 302550000.0 17241.8 24953.0 15618.300000000001 16811.5 16034.7 15215.3 19848.8 17325.7 9699.0 16251.599999999999 True False 17643.50039329738 22031.491159665013 13497.420645180926 13875.687115939221 14584.364216156213 15062.247896387064 18351.58903563944 16866.166154194914 16458.494613067578 18337.651163989394 0.9621461459548781 1.2014347400679868 0.7360495913286058 0.7566774496827399 0.7953234624070226 0.821383707307378 1.0007600685346996 0.9197560801743185 0.8975246865524406 1.0 14.162521238161897 -10.351548614735957 15.949390619992224 0.9999999999999998 0.8971927322215579 0.05111721041054629 0.1303278812013561 0.0 0.0 0.13593053176377023 0.03296799648284714 4.450936365427489e-11 10.351548614735957 -0.10280726777844185 KQPPVS(ph)PGTALVGSQK ddPTM_A459_Selumetinib_30min_R2 1 KQPPVSPGTALVGSQK 16 1 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVS(0.99)PGT(0.01)ALVGSQK 99.873 0.0032426 306550000.0 215680.0 186910.0 223810.0 195320.0 231780.0 189510.0 219450.0 206850.0 196440.0 208630.0 True False 203693.3690354482 201245.39598962554 209410.3082659035 168717.07905420667 202661.7242605096 215613.28229950287 229654.8598319256 207451.899254139 235733.48899219552 202606.30981416127 1.0053653769336406 0.993282964258201 1.0335823620596176 0.8327335866733905 1.0002735079988336 1.0641982596557438 1.1335029992036 1.0239162810103115 1.163505170240847 1.0 17.628319579453688 -6.7280117360796 3.8786336868026177 1.083471053316237 0.9674412523802446 0.383525560120454 0.06669792451766123 0.22615901597937474 7.247326278491693 0.02304798090546817 0.02203039618556021 1.8706315890031138e-07 6.7280117360796 -0.11602980093599247 KQPPVS(ph)PGTALVGSQKEPSEVPTPK ddPTM_A459_Selumetinib_30min_R2 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVS(0.795)PGT(0.205)ALVGSQKEPSEVPTPK 67.895 0.001908 6395300.0 54367.0 60275.0 55741.0 60923.0 56350.0 34014.0 35691.0 35295.0 30348.0 61341.0 True False 51345.49978834479 64897.89868532794 52154.68474621203 52625.18230196305 49270.809224608376 38699.11975165047 37350.70222037482 35397.702606598206 36418.44799396834 59569.92594694178 0.8619366059658629 1.0894406473348939 0.8755203891417556 0.8834186288704751 0.8271087875531907 0.6496418979288192 0.6270060206830312 0.5942210275387368 0.6113562744127936 1.0 15.862296545177072 -6.414867159589208 1.6009113380266589 0.6652587585033249 0.9522368251117952 0.4168420135508325 0.12581343257485786 0.3113554044750177 1.6014411470865273 0.04584667835089131 0.05485407181646684 3.847094375688499e-07 6.414867159589208 0.28697806660847025 KQPPVSPGT(ph)ALVGSQK ddPTM_A459_Selumetinib_30min_R2 1 KQPPVSPGTALVGSQK 16 1 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVS(0.466)PGT(0.534)ALVGSQK 143.72 0.00048806 423460000.0 119540.0 101980.0 120640.0 132080.0 126430.0 101190.0 116610.0 121060.0 112040.0 104840.0 True False 112896.44535653484 109801.5380826169 112878.15374290028 114090.4761492912 110546.73310145937 115128.00398863728 122032.59605833153 121412.2645574381 134451.1306591605 101812.9967929667 1.108860842060331 1.0784628833379164 1.1086811831345482 1.1205885274282843 1.085782135715467 1.1307790519391763 1.198595463273522 1.1925026114723432 1.3205694252626934 1.0 16.63556221278491 -7.123104635708135 3.3066267517014185 1.194218723031793 1.1010611268285095 0.18118293903373817 0.07419481294741342 0.35407780960202706 7.219512298291352 0.028667175564943487 0.02169519685593465 7.531740776664751e-08 7.123104635708135 -0.09315759620328357 KQPPVSPGTALVGS(ph)QKEPSEVPTPK ddPTM_A459_Selumetinib_30min_R1 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVS(0.001)PGT(0.006)ALVGS(0.718)QKEPS(0.268)EVPT(0.006)PK 64.619 0.0027126 18398000.0 827.6 1236.1 1390.6 1620.7 1259.2 1406.0 1180.6 1439.9 738.95 909.98 True False 846.8814697707264 1091.3768373527007 1201.76415801903 1337.6751693068854 1145.305582329816 1391.856916545858 1091.5463914934867 1401.709174545633 1253.9441792273724 1026.7847969558113 0.8247896465564564 1.0629070868485688 1.1704148343274985 1.3027804592284526 1.1154290419232855 1.3555488167261576 1.0630722179853842 1.3651440678722446 1.2212336829928123 1.0 10.003918124645171 -4.785428374367406 1.6653298645158905 1.216132572159841 0.6859632588729536 0.5014812560122692 0.11427112950896705 0.7209093394900143 1.9795581492587715 0.029344988240230123 0.6211705914954316 1.6389723450575595e-05 4.785428374367406 -0.5301693132868874 KQPPVSPGTALVGS(ph)QKEPSEVPTPK ddPTM_A459_Selumetinib_30min_R2 2 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVSPGT(0.001)ALVGS(0.647)QKEPS(0.339)EVPT(0.014)PK;KQPPVSPGT(0.007)ALVGS(0.836)QKEPS(0.117)EVPT(0.04)PK 87.79299999999998 2.9096e-05 98708000.0 340600.0 326580.0 320960.0 268000.0 268350.0 224656.0 265790.0 237167.0 179573.0 290730.0 True False 321670.81552982953 351627.6358797914 300309.78303482593 231497.9376742129 234637.47392056143 255600.32477588046 278149.7616528936 237857.11670488934 215492.61768883877 282335.8694927434 1.1393196907915277 1.2454231781159812 1.0636614595742837 0.819938104535325 0.8310579677393491 0.9053058870454641 0.9851733049457346 0.8424615587535284 0.7632491687152679 1.0 18.10705290273536 -5.571851099118324 3.980184313609953 0.8760077817925515 1.1877894104769222 0.7538913770663156 0.07330782756034891 0.09898567876210079 3.2830417966464873 0.020630464420674677 0.03904436009792637 2.680087053788011e-06 5.571851099118324 0.31178162868437076 KQPPVSPGTALVGSQKEPS(ph)EVPTPK ddPTM_A459_Selumetinib_30min_R1 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVSPGT(0.001)ALVGS(0.036)QKEPS(0.625)EVPT(0.337)PK 57.806 0.0039519 92575000.0 3563.1 6234.2 6063.9 7461.2 4024.6 4970.6 4141.8 3428.0 2409.5 3728.7 True False 3646.1132974143 5504.296965799046 5240.455686618429 6158.241484070171 3660.5756406008413 4920.600276943702 3829.38069141769 3337.078304286708 4088.7455170828257 4207.314965613676 0.8666128700166095 1.3082683399711184 1.2455582074193632 1.4636987091295492 0.87005029823502 1.169534564718757 0.9101720985272467 0.7931610377546251 0.9718182618843808 1.0 12.038684109025025 -6.759299459384017 1.457695438975913 0.9140704450151892 1.211790168212505 0.2868802889403932 0.1790475674001372 0.4722307500755745 2.0913880586134117 0.08097454127513466 0.07344696427089245 1.7406062580334106e-07 6.759299459384017 0.29771972319731577 KQPPVSPGTALVGSQKEPS(ph)EVPTPK ddPTM_A459_Selumetinib_30min_R2 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVSPGTALVGS(0.015)QKEPS(0.589)EVPT(0.396)PK 95.5 3.0044e-06 133110000.0 63708.0 65014.0 51382.0 49442.0 43635.0 36234.0 33258.0 30494.0 19870.0 57908.0 True False 60167.364403330525 70000.36474704133 48076.13806049169 42707.91430779272 38153.181198150574 41224.904600496935 34804.56289947678 30582.73249144655 23844.555214187138 56236.045576947006 1.0699074550148506 1.2447597271266309 0.8548989810229415 0.7594402108049377 0.6784470850807975 0.7330690516652609 0.6189013210726949 0.5438279341601396 0.4240083912294466 1.0 15.77920752966567 -5.558052944408535 1.6601635933501762 0.6461089318993227 1.173804271916936 0.6086694464064706 0.149853185995508 0.24671194651025644 1.3185297764939363 0.04495163769571034 0.12674169105280644 2.7666043508663112e-06 5.558052944408535 0.5276953400176132 KQPPVSPGTALVGSQKEPSEVPT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVSPGTALVGSQKEPS(0.036)EVPT(0.964)PK 101.51 9.0604e-06 53176000.0 1911.6 2202.9 4021.5 3740.9 2193.0 2579.5 2043.4 1667.8 1476.9 1937.9 True False 1956.1365606739012 1944.983443899575 3475.4023885182833 3087.6220403900306 1994.643537205596 2553.552571998608 1889.2646928492209 1623.5645262221028 2506.1914314918545 2186.648341744507 0.8945821435161798 0.8894815900520465 1.5893741678397217 1.412034107837718 0.9121921888977678 1.1677929748691942 0.8640002403596211 0.7424899995244886 1.1461337351996965 1.0 11.094505508516713 -6.826306763127003 1.7581385168376489 0.9302704467346654 1.1834335403510594 0.1383719232679692 0.2356129969793991 0.682707921595618 4.353179602534995 0.1093229672193999 0.09504409540851876 1.4917403492405056e-07 6.826306763127003 0.253163093616394 KQPPVSPGTALVGSQKEPSEVPT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 KQPPVSPGT(0.001)ALVGS(0.001)QKEPS(0.002)EVPT(0.996)PK;KQPPVSPGTALVGS(0.009)QKEPS(0.219)EVPT(0.773)PK 113.79 3.2799e-07 104587300.0 171484.0 211027.0 166037.0 149963.0 147626.0 106997.0 100909.0 90022.0 67861.0 184950.0 True False 161953.6057848422 227212.09234124815 155354.36018741684 129537.78069939578 129079.90208681526 121734.86552793992 105601.46844739003 90283.9491160557 81435.0961947637 179610.01294219017 0.9016958638991306 1.2650302097265553 0.8649537831580675 0.7212169220269986 0.7186676286714667 0.6777732685043673 0.5879486712212377 0.5026665698482788 0.4533995341394171 1.0 17.454508254467854 -5.654885572006651 2.1298036616390936 0.6341890906106379 1.0864989988332043 0.5015489228678012 0.16446818190795143 0.2313015895404959 2.118491552826703 0.04763116060695181 0.10218832553437979 2.213677893049258e-06 5.654885572006651 0.45230990822256645 KQQQEPTGEPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 5 KQQQEPTGEPSPK 13 1 F5H2U8;F5H2A4;F5H6H0;P52926-3;P52926-6;P52926-4;P52926-5;P52926-2;P52926 F5H2U8 HMGA2 High mobility group protein HMGI-C 1 KQQQEPT(0.009)GEPS(0.991)PK;KQQQEPT(0.007)GEPS(0.993)PK;KQQQEPT(0.003)GEPS(0.997)PK;KQQQEPTGEPS(1)PK;KQQQEPTGEPS(1)PK 195.6 0.0003649 112156700.0 20201.109999999997 26609.53 29662.600000000002 30912.4 18769.05 23221.090000000004 19404.719999999998 18706.16 15850.279999999999 18516.57 True False 20671.756558482502 23494.073857165127 25634.58184499875 25514.129637614686 17071.39274144492 22987.506917662784 17941.0063475703 18210.011870628892 26896.767501351984 20893.352126165486 0.9893939676914998 1.1244760398089815 1.2269252770069219 1.2211601797330758 0.8170729444637947 1.1002306752335214 0.8586944899618162 0.8715696629562782 1.2873361507016488 1.0 14.350756356292594 -6.240255433460603 24.989903462122715 0.9817603102128148 1.1455191205594522 0.21483927497291166 0.14118075195280724 1213.7301075071305 1431792.0034217765 0.04124311599297082 0.05319097674548381 5.751015876607604e-07 6.240255433460603 0.1637588103466373 KQQQEPTGEPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 KQQQEPTGEPSPK 13 1 F5H2U8;F5H2A4;F5H6H0;P52926-3;P52926-6;P52926-4;P52926-5;P52926-2;P52926 F5H2U8 HMGA2 High mobility group protein HMGI-C 1 KQQQEPTGEPS(1)PK;KQQQEPTGEPS(1)PK;KQQQEPT(0.001)GEPS(0.999)PK;KQQQEPTGEPS(1)PK 202.92 6.876199999999999e-29 187002000.0 91302.9 86944.7 75896.3 72369.1 70017.0 56800.9 72746.1 62142.2 40632.7 75087.5 True False 86228.65033246748 93613.07891872653 71013.21468764325 62512.30373633916 61220.838500078076 64624.7083877675 76128.93779366244 62323.02351380501 48760.375372496266 72919.52877424561 1.1825179315053735 1.2837861200193281 0.9738572901025706 0.8572779444293095 0.839567116370349 0.886246928279551 1.0440130246775587 0.8546822032648246 0.6686874722333355 1.0 16.15401761787033 -5.3966678665067915 3.6943461364594037 0.8796884493095285 1.2327413596296066 0.6708598749232109 0.09763874974729207 0.13557667702011567 3.262438948275726 0.026880038480828882 0.061195018845606554 4.011734039719341e-06 5.3966678665067915 0.35305291032007813 KQS(ph)EELQSVQAQEGALGTK ddPTM_A459_Selumetinib_30min_R2 2 KQSEELQSVQAQEGALGTK 19 1 Q9BU64-2;Q9BU64 Q9BU64-2 CENPO Centromere protein O 1 KQS(0.987)EELQS(0.013)VQAQEGALGTK;KQS(0.966)EELQS(0.034)VQAQEGALGTK 100.94 0.00062952 10100900.0 70132.0 68722.0 75841.0 80690.0 78227.0 59594.0 64525.0 67416.0 54404.0 92586.0 True False 66234.34420064003 73992.75642394199 70961.47262943727 69699.88280198617 68399.42490174696 67802.5325595301 67525.54035386199 67612.16939868043 65286.320174767796 89912.80161268248 0.7366508774352046 0.8229390598090882 0.789225464635371 0.7751942054061719 0.7607306598718975 0.7540920908193159 0.7510114148677278 0.751974893296435 0.7261070615506097 1.0 16.45623891807329 -10.68227377249022 7.605737597435351 1.0000000949957366 0.7649689699899268 0.8802709601113811 0.026202205491488013 4.4783787491568815e-08 4.9580699474940485e-09 0.02692190856760632 0.0065295192459537904 2.0783860917742007e-11 10.68227377249022 -0.2350311250058098 KQS(ph)LGELIGTLNAAK ddPTM_A459_Selumetinib_30min_R1 2 KQSLGELIGTLNAAK 15 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 1 KQS(1)LGELIGTLNAAK;KQS(1)LGELIGTLNAAK 133.98 0.00025191 739960000.0 19624.7 22014.7 25167.0 27673.0 21677.6 19962.3 21847.7 21025.9 12524.5 17607.9 True False 20081.91732698113 19437.208689643638 21749.45963243557 22840.430036545586 19716.864907491134 19761.497386318213 20199.71039931582 20468.224830251416 21253.16174671253 19868.045480470144 1.0107646143009497 0.9783150893604502 1.0946954824426396 1.1496062891036378 0.992390767721585 0.9946372130939268 1.0166933843176318 1.0302082733991744 1.0697157789176557 1.0 14.27816233395252 KQS(ph)LGELIGTLNAAK ddPTM_A459_Selumetinib_30min_R2 4 KQSLGELIGTLNAAK 15 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 1 KQS(1)LGELIGTLNAAK;KQS(0.998)LGELIGT(0.002)LNAAK;KQS(1)LGELIGTLNAAK;KQS(1)LGELIGTLNAAK 169.28 0.0001084 167562900.0 316594.0 279730.0 299972.0 332104.0 317426.0 254294.0 260687.0 306638.0 257597.0 292509.0 True False 298998.9729061976 301184.3915262839 280672.1281048186 286870.8622886453 277548.10805555485 289320.6902489039 272809.462041491 307530.26581334614 309123.5978615487 284063.50514034653 1.0525779183020076 1.0602713339662497 0.9880612011956538 1.0098828504806054 0.9770635897716863 1.018507076810025 0.960381946659092 1.0826109663802306 1.0882200362514742 1.0 18.11585396863571 -7.7838352457033295 24.999048714765713 1.0640616385253512 1.0097701308616425 0.253208225080654 0.0367028910774898 307.22322703644545 342928.38839618146 0.020246712327952852 0.009738561319938875 1.6449956517063455e-08 7.7838352457033295 -0.054291507663708716 KQS(ph)LYLK ddPTM_A459_Selumetinib_30min_R2 1 KQSLYLK 7 1 A0A494BZT8;Q9Y6A5;H0Y8F2;A0A494C117 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 KQS(0.999)LY(0.001)LK 63.184 0.044796 5389400.0 41308.0 23411.0 35932.0 51369.0 34887.0 50857.0 52007.0 41887.0 31585.0 27087.0 True False 39012.26672902582 25206.54842177042 33620.17423980357 44372.45358353234 30504.183166262843 57862.090116119514 54425.42854991544 42008.88423523385 37902.88255863614 26304.92792952203 1.4830782594634042 0.958244344531395 1.2780941399984465 1.6868494641923395 1.1596375876030434 2.1996673121913735 2.0690202495796908 1.5969967432637313 1.4409042541453887 1.0 14.683045476918727 -5.885431153192968 1.546957287682157 1.6754909265852203 1.1963804527544355 0.1281075592706863 0.36979168692465514 0.640452763976947 3.118188813491155 0.1252202231678896 0.24336096461653062 1.3018736795691218e-06 5.885431153192968 -0.47911047383078476 KQSAGPNS(ph)PTGGGGGGGSGGTR ddPTM_A459_Selumetinib_30min_R1 4 KQSAGPNSPTGGGGGGGSGGTR 22 1 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 KQSAGPNS(0.999)PTGGGGGGGSGGTR;KQSAGPNS(0.95)PT(0.05)GGGGGGGSGGTR;KQS(0.009)AGPNS(0.955)PT(0.036)GGGGGGGS(0.001)GGTR;KQSAGPNS(0.95)PT(0.02)GGGGGGGS(0.008)GGT(0.022)R 131.79 1.1537e-05 17561100.0 5664.7 5949.5 8153.400000000001 9205.3 7164.3 6006.72 6785.799999999999 6141.2 3453.92 4643.51 True False 5796.676488412562 5252.929774152488 7046.213063420359 7597.767159881946 6516.2903299598975 5946.297850465393 6273.941642721075 5978.315426571036 5861.04997566413 5239.549740117674 1.106331035285176 1.0025536610393 1.3448127058456187 1.4500801665662417 1.2436737225847099 1.1348871840907164 1.19741999864671 1.1409979336195346 1.1186171076472111 1.0 12.355227123980223 -8.390814561696052 0.8485913061572338 1.004183975028324 1.223047460184024 0.24509590718299568 0.1168065911166326 0.9748813306176605 1.559073787763137 0.12581726831751658 0.045994826095778055 4.066169124320987e-09 8.390814561696052 0.2188634851557001 KQSAGPNS(ph)PTGGGGGGGSGGTR ddPTM_A459_Selumetinib_30min_R2 3 KQSAGPNSPTGGGGGGGSGGTR 22 1 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 KQSAGPNS(0.498)PT(0.498)GGGGGGGS(0.001)GGT(0.003)R;KQSAGPNS(0.995)PT(0.004)GGGGGGGSGGT(0.001)R;KQS(0.001)AGPNS(0.811)PT(0.187)GGGGGGGS(0.001)GGTR 107.7 2.9566e-05 11188840.0 5071.3099999999995 6820.860000000001 5423.43 6175.25 7646.31 3215.9500000000003 5672.92 4113.2300000000005 3931.55 6917.61 True False 4789.466892262416 7343.99802947833 5074.492418384108 5334.170297099573 6685.712178921296 3658.917921012535 5936.722020677725 4125.198818318119 4717.969856685323 6717.880625190719 0.7129431377959986 1.0932016270041767 0.7553710316548002 0.7940257641818601 0.995211518622585 0.5446536080579222 0.8837194871275615 0.6140625367544404 0.7023003414192673 1.0 12.713790444185747 -6.743674395237974 24.99997042157966 0.7332492790752946 0.8719364883392291 0.12271785637303656 0.1592546591453563 454.50037966117804 639599.4623132495 0.049477073355635975 0.049375851243772084 1.8043700290306997e-07 6.743674395237974 0.13868720926393452 KQSFDDNDS(ph)EELEDKDSK ddPTM_A459_Selumetinib_30min_R1 3 KQSFDDNDSEELEDKDSK 18 2 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KQS(0.003)FDDNDS(0.994)EELEDKDS(0.004)K;KQS(0.453)FDDNDS(0.547)EELEDKDSK;KQS(0.026)FDDNDS(0.973)EELEDKDS(0.001)K 91.565 0.006014800000000001 203029000.0 4257.9800000000005 5191.099999999999 5286.3 6328.000000000001 4684.8 4229.6 4875.400000000001 4144.71 2614.4500000000003 4180.0 True False 4357.182649413195 4583.323598723082 4568.449495567376 5222.933591271651 4261.060667168621 4187.054064169536 4507.644652792939 4034.7788268845275 4436.530698127077 4716.54371664794 0.9238083883403198 0.9717547157562365 0.9686011134471548 1.1073646095627845 0.903428638248045 0.8877377833667758 0.9557092912936116 0.8554524391755358 0.9406317347314086 1.0 12.203514324459114 KQSFDDNDS(ph)EELEDKDSK ddPTM_A459_Selumetinib_30min_R2 2 KQSFDDNDSEELEDKDSK 18 2 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KQS(0.006)FDDNDS(0.994)EELEDKDSK;KQS(0.001)FDDNDS(0.996)EELEDKDS(0.003)K 86.182 0.008312200000000002 157385600.0 158382.0 149420.0 124695.0 123107.0 101244.0 83452.0 131607.0 112813.0 58355.0 109416.0 True False 149579.76249338075 160880.03353897482 116672.25945765058 106339.61422857991 88524.82358715616 94946.75549816941 137726.98627432322 113141.26715280254 70027.63057493142 106256.87578309076 1.4077184313110043 1.5140670413403643 1.098020797221833 1.000778664391169 0.8331208962690356 0.8935586972460074 1.2961701090805127 1.064790078938189 0.6590409331993111 1.0 16.69719667415505 -5.389516347183957 3.2635112653773484 0.9745511536517808 1.4643199853972861 0.6061333056343974 0.15734623971137934 0.17355615253253343 3.4136846347759287 0.04474766441901359 0.10668513051016915 4.078342102837122e-06 5.389516347183957 0.48976883174550534 KQSFDDNDSEELEDKDS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KQSFDDNDSEELEDKDSK 18 2 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KQSFDDNDS(0.002)EELEDKDS(0.998)K 59.15 0.021111 43160000.0 6056.7 6560.4 8939.0 9161.0 5442.3 6095.3 5797.8 6082.3 4315.7 5440.4 True False 6197.809325713338 5792.305318152785 7725.132898412266 7561.203323267949 4950.044925916103 6033.986816089594 5360.46727816444 5920.977645905205 7323.427693743243 6138.728333983602 1.0096243046630142 0.9435676255759614 1.2584256018704119 1.2317214432522803 0.8063632492926874 0.9829375870383177 0.87322112765428 0.9645283719637919 1.192987748488758 1.0 12.583724110246456 -6.252805990213275 24.986640536436397 0.9640400650250229 1.109429285807421 0.22648741856481447 0.12720219926404483 1040.5010263287732 3011402.2544700266 0.03984896069621342 0.050622560124330196 5.587197325331277e-07 6.252805990213275 0.14538922078239813 KQTDFEHR ddPTM_A459_Selumetinib_30min_R2 1 KQTDFEHR 8 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 73.985 0.041682 1659700.0 6668.3 5134.7 4887.6 4799.9 5943.5 6885.8 12992.0 26331.0 8425.8 16414.0 False True 6297.702581319912 5528.514979337261 4573.137137216518 4146.145339710659 5196.824394435845 7834.256446931112 13596.15374315961 26407.61885066828 10111.195436522286 15940.085171306348 0.39508588025968444 0.34683095604088165 0.28689540162863086 0.2601081045146553 0.3260223730667774 0.49148146717769803 0.8529536446664642 1.6566799089759243 0.6343250571034206 1.0 13.960371717528588 -7.29750993951072 2.8369452322143838 1.1259195780067675 0.3287152476021161 0.6680743544388634 0.24045762063174847 0.1462974738504008 2.3475189793829014 0.10407170037997061 0.06854543889833824 5.0406908255870693e-08 7.29750993951072 -0.7972043304046513 KRDFTNEAPPAPLPDASASPLS(ph)PHR ddPTM_A459_Selumetinib_30min_R1 1 KRDFTNEAPPAPLPDASASPLSPHR 25 2 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 KRDFTNEAPPAPLPDAS(0.011)AS(0.034)PLS(0.955)PHR 79.069 8.8069e-05 12324000.0 2734.3 2568.1 5107.0 5225.7 4359.6 3580.8 2874.8 3271.3 1705.2 2375.2 True False 2798.0038699783686 2267.4256581227005 4413.497450742974 4313.129593537967 3965.274949749897 3544.7804031062665 2657.9515214852427 3184.5344973200436 2893.599857119584 2680.08005640722 1.0440001086121402 0.8460290776396795 1.6467782147744818 1.6093286404734977 1.4795360087360765 1.3226397452687364 0.9917433306258613 1.1882236464193796 1.079669187568448 1.0 11.388060380590161 -7.240591743420978 17.837550441002286 1.0805950996749 1.3375744681246324 0.22742750686810742 0.23315470933598706 37.438389165013014 32032.163617431142 0.10030000502093049 0.07736597689576476 5.7465641156027004e-08 7.240591743420978 0.25697936844973235 KREDS(ph)APPSSVAR ddPTM_A459_Selumetinib_30min_R2 2 KREDSAPPSSVAR 13 2 Q9BZE4-2;Q9BZE4;Q9BZE4-3 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 1 KREDS(1)APPSSVAR;KREDS(1)APPSSVAR 65.477 0.029665 11149400.0 21620.4 21809.9 24456.3 23948.6 24303.7 18168.8 21469.0 26932.0 18332.9 29593.0 True False 20418.824721318633 23482.649200118358 22882.808284006125 20686.75936636068 21250.451928165276 20671.387280054892 22467.351040016434 27010.367661167395 21999.992264024713 28738.57319815209 0.7105023823044763 0.8171125629030291 0.7962402352486136 0.7198255537505547 0.7394400474109721 0.7192906598920532 0.7817838027345456 0.9398646020082925 0.7655213817448434 1.0 14.810700816743175 -8.740966995224243 0.5706907126458631 1.0007313467181844 0.7513990094276184 0.5831650770334911 0.05987237483836188 0.8543824957240567 0.5993878829855369 0.07026689724319175 0.028186475441331776 1.8156536404973838e-09 8.740966995224243 -0.24933233729056603 KREDSAPPS(ph)SVAR ddPTM_A459_Selumetinib_30min_R2 1 KREDSAPPSSVAR 13 2 Q9BZE4-2;Q9BZE4;Q9BZE4-3 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 1 KREDSAPPS(0.5)S(0.5)VAR 52.372 0.047691 3191400.0 20175.0 18006.0 22374.0 22430.0 23414.0 20687.0 19361.0 20481.0 15374.0 22166.0 True False 19053.754266923974 19387.002301584664 20934.481198969286 19374.99530609181 20472.523996184194 23536.446472111293 20261.324863093683 20540.596319187916 18449.229585451074 21526.00998581555 0.885150303260072 0.9006314832316636 0.9725202772257353 0.9000736931209665 0.9510598578033947 1.0933956867817356 0.9412485117513545 0.9542221866812768 0.8570668506429243 1.0 14.393793309034232 -5.170142156737618 4.492633248556783 0.9588789150590141 0.8888740929260178 0.16930631098209203 0.05852858769835964 0.4110268626330065 14.232461810561086 0.015626523344392965 0.04529392152427926 6.758617107290502e-06 5.170142156737618 -0.0700048221329963 KREEGS(ph)DIEDEDMEELLNDTR ddPTM_A459_Selumetinib_30min_R1 6 KREEGSDIEDEDMEELLNDTR 21 2 F5H5U2;Q8NHQ9-2;Q8NHQ9 F5H5U2 DDX55 ATP-dependent RNA helicase DDX55 1 KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR 102.47 8.3321e-05 76758400.0 11728.1 13461.21 14861.23 16332.15 12268.25 12261.660000000002 12494.740000000002 12169.72 6621.01 11202.329999999998 True False 12001.341911089967 11885.165275253254 12843.156592893098 13480.046594925296 11158.588953635464 12138.31883309651 11552.251702227122 11846.939492778303 11235.370390562595 12640.258175434623 0.949453859606575 0.9402628577912407 1.0160517621272003 1.0664376002321485 0.8827817279334793 0.960290420071198 0.9139252966112703 0.9372387279084161 0.8888560846326446 1.0 13.625738310201758 -6.279662098989589 24.999872156943574 0.9280365641809406 0.9909237865753685 0.31064701885240154 0.04550385328826622 1044.3907883120362 1432803.436201209 0.014320845930542512 0.016269733488185282 5.252159433941968e-07 6.279662098989589 0.0628872223944279 KREEGS(ph)DIEDEDMEELLNDTR ddPTM_A459_Selumetinib_30min_R2 6 KREEGSDIEDEDMEELLNDTR 21 2 F5H5U2;Q8NHQ9-2;Q8NHQ9 F5H5U2 DDX55 ATP-dependent RNA helicase DDX55 1 KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR;KREEGS(1)DIEDEDMEELLNDTR 118.52 2.9418e-05 50185200.0 119522.0 110014.0 124438.0 131248.0 126048.0 99661.0 108317.0 106702.0 87353.0 107527.0 True False 112879.44572447517 118451.72004923582 116431.79455785024 113371.79598457164 110212.72335658275 113388.39811751738 113353.95512606358 107012.48515453289 104826.04084674836 104422.41612130229 1.08098864130235 1.1343514587101335 1.1150076667695301 1.0857036275896288 1.0554508069278359 1.0858626177141866 1.0855327748247652 1.0248037646459152 1.0038653072820802 1.0 16.67207191963631 -7.707783958465261 0.649983391621919 0.9909472152579895 1.106070748841236 0.7682110150985959 0.020693372272325903 0.3608415418371924 0.3054753519622367 0.020945996400428223 0.011285388072820026 1.9598193510667396e-08 7.707783958465261 0.11512353358324656 KRES(ph)ESESDETPPAAPQLIK ddPTM_A459_Selumetinib_30min_R2 2 KRESESESDETPPAAPQLIK 20 2 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 KRES(0.718)ES(0.181)ES(0.098)DET(0.003)PPAAPQLIK;KRES(0.324)ES(0.324)ES(0.324)DET(0.027)PPAAPQLIK 78.976 0.0052868 31344000.0 76524.0 74862.0 72632.0 72356.0 78160.0 57581.0 67551.0 61735.0 53502.0 75789.0 True False 72271.1024298434 80603.67468073021 67958.93619574244 62500.98797893793 68340.84204073442 65512.260081724744 70692.25534976709 61914.638629220564 64203.89497078208 73600.77464652949 0.9819339915500633 1.0951470968591352 0.9233453930630188 0.8491892684431827 0.9285342765608637 0.8901028609596822 0.9604824906975412 0.8412226491713974 0.8723263481821178 1.0 16.167433330245125 -5.381615002811206 5.868258099570351 0.900930205001563 1.0373114409330908 0.4939809859460783 0.05275386444244291 0.1590249343268007 6.923127529588052 0.013115439985254251 0.027804167912934896 4.15322057837169e-06 5.381615002811206 0.13638123593152784 KRESESES(ph)DETPPAAPQLIK ddPTM_A459_Selumetinib_30min_R1 1 KRESESESDETPPAAPQLIK 20 2 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 KRES(0.012)ES(0.012)ES(0.969)DET(0.007)PPAAPQLIK 84.03 0.0030247 18701000.0 2002.2 2182.1 2847.0 3104.7 2311.5 2284.3 2111.0 1978.1 1381.6 2153.1 True False 2048.84736439699 1926.618717569231 2460.393037451588 2562.5224274369616 2102.425233128472 2261.3220159784546 1951.7655704241502 1925.6343622256522 2344.474291928465 2429.471357970018 0.8433305285430226 0.7930197288594696 1.0127277398764674 1.0547654406504783 0.8653838318494051 0.9307876829089012 0.8033704797635391 0.792614556211375 0.9650141724195614 1.0 11.246426708696543 -7.140341830047557 17.751330877261868 0.872089632882471 0.9193680033940165 0.0035016002382669553 0.09374269533737849 8.248059550602505 1171.9031096895344 0.03766193445636477 0.029172918925699395 7.238659861077727e-08 7.140341830047557 0.04727837051154549 KRESESES(ph)DETPPAAPQLIK ddPTM_A459_Selumetinib_30min_R2 1 KRESESESDETPPAAPQLIK 20 2 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 KRES(0.214)ES(0.315)ES(0.47)DET(0.001)PPAAPQLIK 88.945 0.0007462999999999999 13288000.0 47908.0 45207.0 47996.0 48515.0 38293.0 33620.0 44045.0 31008.0 32379.0 49244.0 True False 45245.465150919146 48674.231536584324 44907.98961409362 41907.173306956945 33482.2909962365 38250.84982802637 46093.17977351178 31098.228146349244 38855.70474484976 47822.197768722406 0.9461184818342133 1.0178167003528888 0.939061601293975 0.8763121575806346 0.7001412013342313 0.79985554016181 0.9638448654415153 0.6502885604870444 0.8125035351316061 1.0 15.54539281317861 -5.8236668354614505 2.92794765452853 0.8086801043463967 0.9783459426112889 0.29073466736901943 0.1008885678179039 0.2869520488217722 4.985171275744131 0.02889394193135135 0.048488206688944976 1.5008357446747587e-06 5.8236668354614505 0.16966583826489223 KRLLS(ph)WK ddPTM_A459_Selumetinib_30min_R1 1 KRLLSWK 7 2 M0QZ22;Q5PRF9;A0A087WZT0;G3V2R1;Q9UPU9-2;Q9UPU9-3;Q9UPU9 M0QZ22;G3V2R1 SAMD4B;SAMD4A Protein Smaug homolog 2;Protein Smaug homolog 1 1 KRLLS(1)WK 60.118 0.037753 15098000.0 4370.0 4169.8 6012.3 5446.6 5730.2 4851.1 5009.5 4504.9 2916.9 4220.0 True False 4471.812497460217 3681.5978775125723 5195.862683199922 4495.453555344529 5211.904421748976 4802.302338446386 4631.62938182841 4385.415418022515 4949.766258053079 4761.678106280933 0.9391253246542712 0.7731723554887778 1.0911831012571542 0.9440901831257266 1.0945520267054945 1.0085314948341146 0.9726884678993776 0.9209810743481157 1.0395003919992085 1.0 12.217254381085416 -5.260821705613807 24.99996715049885 1.0055508377424223 0.8561488422364051 0.46876655478404805 0.06498150928843255 44.644174427700655 1806845.0143590998 0.016134710976660603 0.0378741100226136 5.485020996572018e-06 5.260821705613807 -0.14940199550601718 KRPAS(ph)PSHNGSSGGGYGASK ddPTM_A459_Selumetinib_30min_R2 1 KRPASPSHNGSSGGGYGASK 20 2 K7ELX9;K7EQ79;K7ENM4;K7ENP7;Q6PI98;Q6PI98-3;Q6PI98-4 K7ELX9 INO80C INO80 complex subunit C 1 KRPAS(0.564)PS(0.412)HNGS(0.02)S(0.004)GGGYGASK 49.592 0.030699 12476000.0 36450.0 28602.0 46084.0 56806.0 60428.0 39698.0 30358.0 38389.0 34482.0 46971.0 True False 34424.25492091098 30795.681430074677 43119.00561246543 49068.924804184164 52836.49440682579 45166.03915743578 31769.707153235795 38500.705634358914 41379.36350757928 45614.82518468566 0.7546725166989852 0.6751243988196575 0.9452849032717952 1.0757231800300346 1.1583184675793665 0.9901613998205007 0.6964776698059536 0.8440393113089211 0.9071472561835365 1.0 15.477215167631964 -5.268620172796316 23.413810334896855 0.9505777563465677 0.7148984507741504 0.38500497294315617 0.11992600987190834 245.66396329784865 801023.3479845129 0.03614573458241656 0.0780585673063602 5.3874075082257216e-06 5.268620172796316 -0.23567930557241734 KRPES(ph)PPSILTPPVVPTADK ddPTM_A459_Selumetinib_30min_R2 1 KRPESPPSILTPPVVPTADK 20 2 Q6P2C6;P55198 Q6P2C6 MLLT6 Protein AF-17 1 KRPES(0.771)PPS(0.203)ILT(0.026)PPVVPTADK 58.29 0.014057 4319400.0 17865.0 19221.0 23365.0 24161.0 25313.0 21227.0 19805.0 23703.0 19301.0 18007.0 True False 16872.13481926131 20695.18889474391 21861.721337888528 20870.230119950254 22132.954638908806 24150.82657047935 20725.971742863 23771.97180575712 23161.739314998784 17487.09112219528 0.9648336994050747 1.183455198473621 1.2501634025421644 1.1934649378855793 1.2656738896280364 1.3810659761374606 1.185215516865284 1.3594011513775912 1.3245049821694486 1.0 14.094002704680584 -4.077904371541919 1.142294483720513 1.264763512339342 2.6727164557779624e-10 0.3878684241052941 0.1035597091778924 6.335403505707943 2.1791786904925656 0.02953408226496357 14.185525710674847 8.357870321427563e-05 4.077904371541919 -1.2647635120720704 KRS(ph)ESPPAELPSLR ddPTM_A459_Selumetinib_30min_R1 1 KRSESPPAELPSLR 14 2 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 KRS(0.832)ES(0.168)PPAELPSLR 83.964 0.030181 40049000.0 3048.0 5028.9 7917.7 10121.0 5757.3 5835.6 4593.8 4298.3 2433.9 2650.6 True False 3119.0124696244247 4440.114050127816 6842.519828812939 8353.557344699804 5236.553231533875 5776.8991623008615 4247.285967510404 4184.295121153897 4130.150534977337 2990.8303290303893 1.0428583792767647 1.4845757069633825 2.2878328343792225 2.793056250505518 1.7508693758738019 1.9315369067337564 1.420102613740496 1.399041289818143 1.3809377599552126 1.0 11.546330352789148 -7.376590210670283 2.116919170602613 1.2795148547548363 1.926831369546397 0.289321532880365 0.44684310168795127 0.4854150930602858 4.247678796749035 0.26255928969626385 0.15427281594356027 4.201552449126716e-08 7.376590210670283 0.6473165147915607 KRS(ph)VQEGENPDDGVR ddPTM_A459_Selumetinib_30min_R2 1 KRSVQEGENPDDGVR 15 2 H7C5M1;Q5TCT4;A2A2V2;P42696-2;P42696 H7C5M1 RBM34 RNA-binding protein 34 1 KRS(1)VQEGENPDDGVR 60.918 0.031995 6157100.0 40787.0 35342.0 42717.0 45012.0 41700.0 25366.0 32518.0 33138.0 33097.0 49709.0 True False 38520.22182329759 38052.61775755885 39968.63472675299 38881.28794996897 36461.27319727006 28859.936250378265 34030.15143319461 33234.42609370876 39717.32480744595 48273.77201050729 0.7979534272754418 0.7882669236884224 0.8279575649910557 0.8054329780052418 0.7553019306080718 0.5978388480621858 0.7049407994425543 0.6884572037684343 0.8227516341337706 1.0 15.558951939877433 -8.590550172947307 5.367578660981793 0.9999827421714985 0.7462537560917945 0.587688764192002 0.06464645810509263 0.3857772672137191 28.973519789637415 0.07085029681091534 0.018398392715502684 2.5671416155711295e-09 8.590550172947307 -0.25372898607970407 KRSES(ph)PPAELPSLR ddPTM_A459_Selumetinib_30min_R2 1 KRSESPPAELPSLR 14 2 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 KRS(0.122)ES(0.878)PPAELPSLR 58.688 0.037575 7917600.0 20859.0 23756.0 18730.0 27355.0 18144.0 15941.0 12732.0 10509.0 8846.1 19885.0 True False 19699.740285192926 25578.00881242059 17524.932191682088 23629.201809992916 15864.588510581958 18136.728052009774 13324.063227979388 10539.579450141393 10615.56718068549 19310.86838256529 1.0201374632628497 1.324539544555829 0.907516526160179 1.2236219180762689 0.8215367738151648 0.9391979528162708 0.6899774243197133 0.5457848524127995 0.5497198246283784 1.0 14.237125421261707 -6.745021025139805 1.1709403036769108 0.6581318999936913 1.1261868466236649 0.5125543227786709 0.17234738452925435 0.3373521471544084 0.9792825529758893 0.08413180011800775 0.07708468410331977 1.7987838299859594e-07 6.745021025139805 0.4680549466299736 KS(ph)ASPEVSEGHENQHGQESEAK ddPTM_A459_Selumetinib_30min_R1 1 KSASPEVSEGHENQHGQESEAK 22 1 O60930 O60930 RNASEH1 Ribonuclease H1 1 KS(0.824)AS(0.173)PEVS(0.003)EGHENQHGQESEAK 106.72 4.1895e-05 20264000.0 2834.0 2355.7 3189.6 3486.6 3225.5 2552.9 2850.5 2525.9 851.69 1605.9 True False 2900.0266859959374 2079.8935488647803 2756.4698392186797 2877.7307615878212 2933.7540945082783 2527.2201438477387 2635.484490049284 2458.904926720476 1445.2557250235625 1812.032907790653 1.6004271630650662 1.1478232762343814 1.521202968978938 1.5881227924809243 1.619040185139518 1.3946877746989086 1.4544352250548451 1.3569869046796346 0.7975880122319142 1.0 10.823393440639657 -8.154652501618767 4.214521481337436 0.9016513240687068 1.4673162427112243 0.7299475087772902 0.13774157224165126 0.11690572289881236 3.405051755327482 0.10575598308635849 0.03630405986549161 7.004021948811203e-09 8.154652501618767 0.5656649186425174 KS(ph)ASPEVSEGHENQHGQESEAK ddPTM_A459_Selumetinib_30min_R2 1 KSASPEVSEGHENQHGQESEAK 22 1 O60930 O60930 RNASEH1 Ribonuclease H1 1 KS(0.71)AS(0.269)PEVS(0.021)EGHENQHGQESEAK 59.792 0.011295 12399000.0 46003.0 40892.0 55812.0 65551.0 64692.0 54247.0 41488.0 43547.0 39029.0 63551.0 True False 43446.337424599966 44028.28491149615 52221.116683511 56622.840718217805 56564.81260618212 61719.03184476341 43417.27420691236 43673.714560406064 46835.890561374385 61716.11750467218 0.7039706835302932 0.7134001082968808 0.846150386559194 0.9174725016351071 0.9165322592092725 1.0000472217017056 0.7034997657398894 0.7076549259129882 0.7588923680727114 1.0 15.913359685901769 -12.032455750009927 2.239142316929926 3.6019805565909286 0.811988762690063 0.23926133085110546 0.10268954969086135 5607328.081602761 745372.4912784996 73337193.65033911 0.02940875558669951 9.279920378323335e-13 12.032455750009927 -2.7899917939008656 KS(ph)DASDMNSDTSPSCR ddPTM_A459_Selumetinib_30min_R1 2 KSDASDMNSDTSPSCR 16 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 KS(0.861)DAS(0.136)DMNSDT(0.002)SPSCR;KS(0.988)DAS(0.008)DMNS(0.004)DTSPSCR 154.39 0.00056705 5112000.0 1169.21 1707.67 1465.23 1492.4499999999998 1475.47 1454.02 1458.54 1395.3899999999999 932.44 1029.62 True False 1196.450318113378 1507.7352025257549 1266.2598139322752 1231.821624256222 1342.013999015386 1439.3938789445303 1348.52115352271 1358.3797243344889 1582.2825772769083 1161.7817563480983 1.0298408557165295 1.2977783428663174 1.0899291601140213 1.0602865964501669 1.1551343371355933 1.238953763113881 1.1607353499521298 1.1692210838327926 1.3619447616827767 1.0 10.182123364931218 -6.529696437263112 23.423683579699972 1.195367213467067 1.1272895825090454 0.07476364566690774 0.10683963409522478 210.01822907645033 721550.1178663118 0.03388264293547913 0.03397729547597812 2.953272781143712e-07 6.529696437263112 -0.06807763095802155 KS(ph)FTPDHVVYAR ddPTM_A459_Selumetinib_30min_R2 1 KSFTPDHVVYAR 12 1 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 KS(0.5)FT(0.5)PDHVVYAR 76.52199999999998 0.032713 7386500.0 53654.0 54656.0 58747.0 57033.0 69668.0 50646.0 42907.0 42507.0 36804.0 66681.0 True False 50672.12547397965 58847.93945326065 54967.28197889732 49265.007012587324 60915.68300017764 57622.026781386776 44902.260518607574 42630.68833258734 44165.82838968006 64755.746271955555 0.7825116440040898 0.9087678366969348 0.8488402210369178 0.7607820131620201 0.9406992661986976 0.8898365025304595 0.6934096679240012 0.6583305851121024 0.6820372080061629 1.0 15.98272059937907 -7.26042723329804 24.998927799166513 0.7299719116095247 0.8569728102400416 0.1519282760373052 0.1035945592080017 126.79606510512399 3131781.349079888 0.039453379320770525 0.028780052605651158 5.4900053377695944e-08 7.26042723329804 0.1270008986305169 KS(ph)GIPTSEPGSQ ddPTM_A459_Selumetinib_30min_R1 1 KSGIPTSEPGSQ 12 1 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 KS(0.998)GIPT(0.002)SEPGSQ 96.464 0.030699 5833700.0 2410.1 2591.5 3075.5 2812.5 2113.4 2723.7 2353.7 2135.3 1425.1 1754.1 True False 2466.2506407617534 2288.085975244335 2657.8639925122425 2321.3496721636393 1922.2433431510744 2696.3020509217326 2176.1585140252573 2078.6649075680884 2418.2906148141683 1979.2558213808966 1.2460494566291527 1.1560334700180253 1.3428602628324677 1.1728396335063291 0.9711949927776161 1.3622807227822444 1.0994831949045296 1.0502254863233575 1.221818114005578 1.0 10.950742379303708 -14.52287871820562 0.05877941493670874 0.329754084296765 1.4647967345647885 0.22526866690295755 0.11226112957339071 648.0949133785864 2.776763505044015 62.858140894104665 10.808399557139992 3.0000001870255303e-15 14.52287871820562 1.1350426502680235 KS(ph)LSDSESDDSK ddPTM_A459_Selumetinib_30min_R1 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 KS(0.911)LS(0.088)DS(0.001)ES(0.001)DDSK 73.983 0.026994 445540000.0 2899.8 3709.4 3305.7 4121.5 3302.8 3984.6 3457.9 4012.0 2641.4 3787.8 True False 2967.3596979714275 3275.1017235467243 2856.804096910331 3401.7573951368695 3004.0623231567006 3944.518541727334 3197.067819028738 3905.588727187362 4482.262879776956 4274.001026296425 0.6942814659412356 0.7662847302553685 0.6684144620774352 0.7959187127487927 0.7028688820320261 0.9229100595573325 0.748026918888953 0.9138015417304882 1.04872760960963 1.0 12.06137153908765 -7.691485225241222 0.7532320081777508 1.034405934636975 0.7248838439553612 0.712231270542976 0.06888178725462446 0.34692442653669187 0.3732620220735164 0.060359879836193175 0.029243887609832937 2.0347674177440538e-08 7.691485225241222 -0.30952209068161374 KS(ph)LVGTPYWMAPELISR ddPTM_A459_Selumetinib_30min_R2 1 KSLVGTPYWMAPELISR 17 1 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 KS(1)LVGTPYWMAPELISR 78.501 0.00961 6775700.0 15596.0 15372.0 20469.0 22223.0 20121.0 16945.0 21433.0 17595.0 13865.0 15752.0 True False 14729.236755734635 16550.982971229554 19152.046824962126 19196.18906318671 17593.22009597772 19279.019938605194 22429.67696868379 17646.198536990945 16638.387420468276 15297.198831388896 0.9628714981144889 1.0819616815902249 1.2519969855960376 1.2548826275172242 1.1500942290086162 1.2602974015769377 1.4662604059678883 1.153557506278996 1.0876754367817554 1.0 13.900979875470686 -5.008504727519836 2.921859407708168 1.2197054125389182 0.9644795564231651 0.286493274731366 0.11848516971639161 0.33648276250375464 5.374456435941397 0.03139504097228102 0.15799230765040706 9.806076398430326e-06 5.008504727519836 -0.2552258561157531 KS(ph)MDQELDT(ph)T(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 KSMDQELDTTVK 12 1 G3XAE9;Q9Y4F4 G3XAE9 FAM179B Protein FAM179B 3 KS(1)MDQELDT(1)T(1)VK 80.455 0.024612 13590000.0 1993.2 2350.7 2609.0 2705.8 2057.9 2617.8 2051.0 2064.7 1219.0 1773.1 True False 2039.6376819079405 2075.478951189218 2254.7121302111655 2233.282824156581 1871.7633083517549 2591.467308772225 1896.291418730427 2009.9374489092072 2068.553967762593 2000.69465645657 1.0194647520678355 1.037379164527334 1.1269646384743615 1.1162537056563882 0.9355567089217075 1.2952837657706209 0.9478165059374669 1.0046197916422723 1.0339178750175744 1.0 10.966285286373612 KS(ph)PAKSPNPSTPR ddPTM_A459_Selumetinib_30min_R2 1 KSPAKSPNPSTPR 13 2 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 KS(1)PAKSPNPSTPR 80.632 0.041462 23667000.0 53103.0 73189.0 70632.0 78762.0 62721.0 42262.0 31430.0 22377.0 16180.0 71226.0 True False 50151.74784815189 78802.36096027336 66087.61401830695 68034.47972797154 54841.427247145686 48083.2068837612 32891.55727736349 22442.113365288227 19416.452106972694 69169.5203126273 0.7250555970531488 1.139264239568357 0.955444156900453 0.9835904516971394 0.7928553935212713 0.6951502145227879 0.4755209683210561 0.324450903575101 0.2807082081705301 1.0 16.077848830984145 -6.8415166506780505 1.65202784957755 0.46381153904106576 0.9620098928821347 0.445930537190949 0.2093876330992829 0.2889560496928585 1.6282613461658695 0.08951609690182018 0.07651550040609675 1.440400784793376e-07 6.8415166506780505 0.4981983538410689 KS(ph)PGVEIK ddPTM_A459_Selumetinib_30min_R2 1 KSPGVEIK 8 1 Q9Y597-3;Q9Y597-2;Q9Y597 Q9Y597-3 KCTD3 BTB/POZ domain-containing protein KCTD3 1 KS(1)PGVEIK 65.232 0.043851 6486500.0 51058.0 49500.0 47040.0 46766.0 52672.0 33337.0 47558.0 45961.0 29346.0 45318.0 True False 48220.40076136826 53296.49083241371 44013.49761327952 40396.390124150224 46054.87246634554 37928.869146844605 49769.54123438923 46094.73890074682 35216.01999574913 44009.551589695446 1.0956803470967142 1.2110209921996282 1.0000896628900213 0.9179005162508581 1.0464744766254104 0.8618326653372539 1.1308804438271634 1.0473803353074747 0.800190384216383 1.0 15.42552905183591 -5.34529841292266 6.063130434375508 0.9781354144345084 1.152439079244928 0.3631657573337027 0.09433224445055638 0.22458294968940945 12.916501079763709 0.0242274836021596 0.05149467834091155 4.515455712442032e-06 5.34529841292266 0.1743036648104196 KS(ph)PLGGGGGSGASSQAACLK ddPTM_A459_Selumetinib_30min_R1 1 KSPLGGGGGSGASSQAACLK 20 1 J3QQY0;J3KSZ8;Q68DK7;Q68DK7-2 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 KS(0.89)PLGGGGGS(0.006)GAS(0.098)S(0.006)QAACLK 65.387 0.0086863 15631000.0 1672.2 1807.4 2229.0 2287.5 1861.6 1656.4 1695.8 1543.1 1025.5 1638.4 True False 1711.1590064652123 1595.7887677625363 1926.3140430205794 1888.0310666930957 1693.2186086921736 1639.7381198908677 1567.8844407035876 1502.1719753047898 1740.1986004434277 1848.704599367461 0.9255989340052974 0.8631929451079093 1.0419804460267328 1.0212724452241262 0.9158946265788015 0.8869659979490008 0.8480989560149541 0.812553815151843 0.9413070108868886 1.0 10.852299002603507 -6.504505478722141 6.254473405880997 0.8846297676075876 0.9625666449583525 0.1645965620064168 0.06638142488303321 0.2644788900720422 40.74331021711833 0.02202724817237326 0.0238172324234427 3.129640990192723e-07 6.504505478722141 0.07793687735076493 KS(ph)PLGGGGGSGASSQAACLK ddPTM_A459_Selumetinib_30min_R2 1 KSPLGGGGGSGASSQAACLK 20 1 J3QQY0;J3KSZ8;Q68DK7;Q68DK7-2 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 KS(1)PLGGGGGSGASSQAACLK 122.68 0.00012387 16632000.0 75437.0 67882.0 84852.0 97375.0 82985.0 78634.0 68376.0 73255.0 72630.0 82349.0 True False 71244.51353823766 73088.33112496797 79392.7146998723 84112.35701875555 72559.68240468728 89465.11973161896 71555.6194844737 73468.15992198192 87158.02945175706 79971.37040160265 0.8908752367310927 0.9139312076050564 0.9927642142578721 1.0517808635310057 0.9073207329111015 1.1187143509275923 0.8947654532507513 0.918680767292561 1.0898653982552036 1.0 16.28719598989838 -5.207916941501045 4.083848718785553 0.9935404446481421 0.8973271691376178 0.21853079942474885 0.07159788093382946 0.3405797217107881 11.866496164797555 0.018102527559833683 0.051940788706005284 6.195595540541047e-06 5.207916941501045 -0.09621327551052428 KS(ph)PLSSILFSALDSDTR ddPTM_A459_Selumetinib_30min_R1 1 KSPLSSILFSALDSDTR 17 1 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;A0A1W2PRR3;I3L233;A0A1W2PPV8 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 KS(0.964)PLS(0.03)S(0.005)ILFSALDSDTR 93.754 0.003677 6651000.0 328.89 298.23 435.29 636.58 387.14 359.17 400.74 483.95 261.19 420.11 True False 336.5524970914625 263.3130929566344 376.1800088768183 525.413253086553 352.1232553551185 355.5570759002674 370.51185916237495 471.11407390885415 443.2203534371708 474.03521071793455 0.709973625338396 0.555471591567728 0.7935697610038022 1.1083844431952756 0.7428208862835773 0.7500646953245732 0.7816125274770799 0.9938377218758575 0.9349945814487195 1.0 8.888850414386628 -3.1424353625838943 0.2361984212948227 0.9732832452924253 4.5915762584401474e-27 0.3432552665355886 0.1284409901588599 31.108282131396773 0.796205288866166 0.20586744605933827 10.087269309030875 0.0007203849604234329 3.1424353625838943 -0.9732832452924253 KS(ph)PLSSILFSALDSDTR ddPTM_A459_Selumetinib_30min_R2 2 KSPLSSILFSALDSDTR 17 1 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;A0A1W2PRR3;I3L233;A0A1W2PPV8 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 KS(0.998)PLS(0.002)SILFSALDSDTR;KS(0.958)PLS(0.019)S(0.023)ILFSALDSDTR 77.53 0.01016 58074000.0 55866.0 39979.0 57699.0 62325.0 65383.0 43477.0 52038.0 48351.0 40409.0 56498.0 True False 52761.191369317225 43045.260747253844 53986.70915792122 53836.22748337818 57169.00300856372 49465.56210508934 54457.87011134081 48491.69340506105 48491.92912179605 54866.75594056694 0.9616240374493707 0.7845417504523424 0.9839602912991793 0.9812176163958909 1.0419606923815694 0.9015579882045822 0.9925476580086301 0.8838082837918918 0.8838125799586865 1.0 15.743644656891508 -5.294094633456909 24.99773545285885 0.9574174167879522 0.8730827916739032 0.22146693908730475 0.06411027920858213 841.0253947206253 643807.0116448485 0.016701895051691753 0.03477112240765775 5.080487258745969e-06 5.294094633456909 -0.08433462511404899 KS(ph)PPPSFCLEYTSAIFEFK ddPTM_A459_Selumetinib_30min_R1 1 KSPPPSFCLEYTSAIFEFK 19 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 KS(0.962)PPPS(0.038)FCLEYTSAIFEFK 130.98 0.00014201 4948000.0 2093.8 2795.4 2195.3 2294.7 2242.6 2288.7 1948.5 2030.2 1256.5 1934.0 True False 2142.581466174418 2468.1132684537984 1897.1903179197293 1893.973721853833 2039.7572259631875 2265.6777559733323 1801.5230762536494 1976.3525009810016 2132.1887288709568 2182.247738755291 0.9818232037195292 1.1309959106025054 0.8693743997195513 0.8679004167208424 0.9347047036587253 1.0382312309168107 0.8255355449611789 0.9056499250210118 0.9770608034114007 1.0 11.09159917696771 -5.267077434884356 24.99671829884992 0.9224068885974988 1.0564095586442 0.35009514601181846 0.07010618193722623 434.60296248167236 1926852.260650214 0.018089698719345203 0.03940828478735556 5.406579148229361e-06 5.267077434884356 0.1340026700467012 KS(ph)PRPAGPQLFLPDPDPQR ddPTM_A459_Selumetinib_30min_R2 1 KSPRPAGPQLFLPDPDPQR 19 2 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 1 KS(1)PRPAGPQLFLPDPDPQR 67.64399999999999 0.0080053 32645000.0 224490.0 219300.0 240450.0 269680.0 249980.0 168820.0 143110.0 163350.0 119720.0 194720.0 True False 212013.74450467256 236119.60483936002 224979.7087821656 232949.11877605147 218575.27755044546 192073.42260462252 149764.89856708515 163825.32145595158 143667.34525628982 189097.9276566813 1.1211849179521223 1.2486631015229812 1.189752376295894 1.2318967302433088 1.155884045156127 1.0157352065398804 0.7919965090204074 0.866351754808156 0.7597510297263889 1.0 17.528774027170222 -6.941494475287758 2.4167252595831856 0.843355599922113 1.199371257188027 0.8417249127072274 0.0683497923412859 0.09885891405373672 1.1700160598044378 0.02613783390883774 0.021576404117531128 1.1442094353499954e-07 6.941494475287758 0.3560156572659141 KS(ph)PSLTEASEK ddPTM_A459_Selumetinib_30min_R2 1 KSPSLTEASEK 11 1 Q6PJP8 Q6PJP8 DCLRE1A DNA cross-link repair 1A protein 1 KS(0.998)PS(0.002)LTEASEK 64.64 0.042495 2489600.0 18387.0 14355.0 20302.0 17418.0 16600.0 15459.0 14474.0 19890.0 15424.0 17916.0 True False 17365.12414899288 15455.982341399975 18995.791423146267 15045.638352274047 14514.559594117094 17588.336927170138 15147.069679686902 19947.87660703323 18509.23098256779 17398.71852864167 0.9980691463228462 0.8883402714950773 1.0917925588528548 0.8647555466516688 0.8342315309155274 1.010898411754654 0.870585362637592 1.1465141282787665 1.0638272555589654 1.0 14.08669343042483 -7.761177986953581 24.999999966805476 1.0788780210021607 0.937155261114934 0.3567190340966475 0.08169067700027263 7.1984393923544605 688719.3695628621 0.04039920408161649 0.021436551226010684 1.7330935782634366e-08 7.761177986953581 -0.1417227598872267 KS(ph)PSSDSWTCADTSTER ddPTM_A459_Selumetinib_30min_R1 1 KSPSSDSWTCADTSTER 17 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 KS(0.698)PS(0.29)S(0.011)DS(0.001)WTCADTSTER 184.21 1.1209000000000002e-07 7060200.0 2940.8 3269.3 3450.9 3453.3 3258.5 2920.7 3379.5 2774.3 1586.7 2655.1 True False 3009.3149181993135 2886.528836143664 2982.2867344368397 2850.2459814694057 2963.7692503349012 2891.320409783421 3124.581594148941 2700.716551803564 2692.51401201715 2995.9079478640997 1.0044750942180223 0.9634904964959233 0.9954533938744776 0.9513796922570528 0.9892724682839099 0.9650898692814499 1.042949799701482 0.9014684692595482 0.8987305547677955 1.0 11.548777580955347 -7.78457198406948 24.999639105511346 0.925074626992623 0.9846545747487826 0.31560440382958443 0.03568210378564754 251.5021366912799 271797.06767531566 0.018338975661220745 0.008818197142700856 1.6422074421426794e-08 7.78457198406948 0.0595799477561596 KS(ph)PSSDSWTCADTSTER ddPTM_A459_Selumetinib_30min_R2 4 KSPSSDSWTCADTSTER 17 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 KS(0.568)PS(0.391)S(0.041)DS(0.001)WTCADTSTER;KS(0.963)PS(0.028)S(0.008)DSWTCADTSTER;KS(0.874)PS(0.103)S(0.021)DS(0.002)WTCADTSTER;KS(0.882)PS(0.094)S(0.023)DS(0.001)WTCADTSTER 90.453 0.0046069 72804800.0 68313.0 61652.0 66357.0 78917.0 76539.0 48995.5 59721.0 58430.2 43494.6 64828.0 True False 64516.43693860606 66380.5101575751 62087.66286403884 68168.36846058168 66923.48655265835 55744.18538813407 62498.14483491649 58600.222208359664 52194.73534066347 62956.24719662774 1.024782127452824 1.0543911543877855 0.9862033654916549 1.0827895800026837 1.0630158170584716 0.8854432700543818 0.9927234804787446 0.9308086936207753 0.8290636380794199 1.0 15.942061924331009 -6.755022694013884 24.99995072202413 0.9273530856614104 1.042051692174289 0.5521039396694072 0.05162235238723888 118.03250047428814 459864.46016686887 0.01704387230428283 0.01665376513332019 1.75783175623946e-07 6.755022694013884 0.11469860651287866 KS(ph)PTMEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R1 2 KSPTMEQAVQTASAHLPAPAAVGR 24 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 KS(0.718)PT(0.282)MEQAVQTASAHLPAPAAVGR;KS(0.82)PT(0.18)MEQAVQTASAHLPAPAAVGR 76.10600000000002 0.0002739 58421000.0 3873.3 4878.7 3024.7 3953.4 4908.3 3824.3 4998.0 3814.3 1570.45 3026.2 True False 3963.5403538701753 4307.499535953901 2613.962353487816 3263.0129045090616 4464.345131630746 3785.8310141865772 4620.996836087117 3713.1323734074667 2664.938948870192 3414.6422476842095 1.1607483497160576 1.2614790140534407 0.7655157301648775 0.9555943691383828 1.307412258094809 1.1087050237119587 1.353288719842042 1.0874147579957143 0.7804445548219694 1.0 11.73751871983096 -8.132293409194965 6.414862171600564 0.8938810326290245 1.1272026764379182 0.23708389726586898 0.16964065196080427 0.3608764332528002 16.89373705807072 0.12327510695370825 0.045686242444339394 7.374058706626912e-09 8.132293409194965 0.23332164380889364 KS(ph)PVGMLDLSSWSSPEVLR ddPTM_A459_Selumetinib_30min_R1 1 KSPVGMLDLSSWSSPEVLR 19 1 O95613-2;O95613 O95613-2 PCNT Pericentrin 1 KS(0.999)PVGMLDLSSWSSPEVLR 80.238 0.0033066000000000003 6398900.0 1241.6 1381.0 1222.0 1351.2 1331.4 1305.9 1218.4 1268.1 721.26 1189.9 True False 1270.5268642669575 1219.3118779905171 1056.0591119655217 1115.2382851653379 1210.975105077762 1292.7638316623309 1126.4951070605327 1234.4658686306805 1223.9255412538532 1342.6352556075085 0.946293387545582 0.9081482650616152 0.7865569651585542 0.8306338452737269 0.9019390039254007 0.9628555680056143 0.8390179703353776 0.9194350166770467 0.9115845395405305 1.0 10.390851715714602 -6.507542763387733 23.684844174974213 0.9178848225211541 0.8651359556587491 0.1902363874786609 0.05552385815375844 674.8300433806671 1042207.0769178737 0.018154545651314056 0.01991404578422531 3.1078298710428004e-07 6.507542763387733 -0.052748866862404986 KS(ph)QENLGNPSK ddPTM_A459_Selumetinib_30min_R2 1 KSQENLGNPSK 11 1 C9J1M4;C9J8V3;C9JJN3;C9JR71;C9JTF7;C9JP72;C9J3Y6;C9IYB9;C9K0C5;B4DGG1;Q9H0X4-2;Q9H0X4 C9J1M4 ITFG3 Protein ITFG3 1 KS(1)QENLGNPSK 82.529 0.02044 8309400.0 45500.0 11594.0 28407.0 34511.0 22796.0 20320.0 77887.0 50607.0 30421.0 23794.0 True False 42971.292150931404 12483.22251941423 26579.324547203032 29810.542265204396 19932.162681174294 23118.895553405604 81508.89983016267 50754.25799156014 36506.05003375874 23107.00539576357 1.8596651281697345 0.5402354093751542 1.1502712745320118 1.2901084218671561 0.8626025891190838 1.0005145693887367 3.527454052748284 2.1964879101497683 1.5798693689858982 1.0 14.496042682166816 KS(ph)REDLSAQPVQTK ddPTM_A459_Selumetinib_30min_R2 2 KSREDLSAQPVQTK 14 2 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 KS(1)REDLSAQPVQTK;KS(1)REDLSAQPVQTK 121.51 0.0021584 47997000.0 139938.0 149629.0 149693.0 153337.0 153729.0 115128.0 120365.0 122702.0 98198.0 154723.0 True False 132160.8061761986 161105.06316693348 140061.91535341486 132452.23607892092 134416.18866530302 130985.83697207067 125962.21099872267 123059.04250559046 117840.3438813663 150255.74497136785 0.8795723997201081 1.0722056797071755 0.9321568062512653 0.8815119588549543 0.894582690937487 0.8717526041818289 0.8383187679294761 0.8189972538423747 0.7842651467590905 1.0 17.19706062732503 -5.701947566209435 2.757415233453531 0.860086113743851 0.980534505898034 0.27228335505823975 0.06928470992863314 0.29124651291042775 4.483203096877694 0.01934674844566961 0.03622354319559942 1.9863347195561565e-06 5.701947566209435 0.12044839215418301 KS(ph)SGTGTEPVAK ddPTM_A459_Selumetinib_30min_R2 1 KSSGTGTEPVAK 12 1 Q6ULP2-7;Q6ULP2-8;Q6ULP2-6;Q6ULP2;Q6ULP2-9;B8ZZI9;A0A0U1RR74 Q6ULP2-7 AFTPH Aftiphilin 1 KS(0.495)S(0.495)GT(0.005)GT(0.005)EPVAK 81.52600000000002 0.019545 7252500.0 13563.0 11085.0 11903.0 11042.0 12880.0 10854.0 16637.0 23795.0 13838.0 20656.0 True False 12809.222756990823 11935.183856107178 11137.173939006512 9538.060551487544 11261.899251339051 12349.03997719804 17410.65346559008 23864.239510525706 16605.986666025234 20059.60760926671 0.6385579920852236 0.5949859084279204 0.555203977861541 0.47548589869132607 0.5614217122640285 0.6156172253086991 0.8679458643820668 1.1896663172763864 0.8278320787468422 1.0 14.292005764876324 -7.336703820419278 2.9853059019161345 1.0099342425373474 0.5640844574281046 0.8239856008191391 0.09154696299614448 0.09918287507350268 1.730078403926305 0.04076717929856373 0.02625946402935987 4.605705658111177e-08 7.336703820419278 -0.4458497851092428 KS(ph)SLLSEEQQETSTLVETIR ddPTM_A459_Selumetinib_30min_R1 2 KSSLLSEEQQETSTLVETIR 20 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 KS(0.498)S(0.498)LLS(0.005)EEQQETSTLVETIR;KS(0.5)S(0.5)LLSEEQQETSTLVETIR 173.87 2.9773e-10 11175800.0 1400.55 2255.4 2617.6 2251.1000000000004 2471.0 2217.74 2188.5 2042.5 1113.66 1644.5300000000002 True False 1433.1800900040976 1991.3367194929863 2262.1442974475835 1857.9876433804707 2247.498486290483 2195.431549146809 2023.4196830285418 1988.326265024972 1889.7996814917863 1855.6214445787166 0.7723450783516213 1.0731373714777699 1.2190763930092219 1.0012751516795988 1.2111837211499432 1.1831246914939808 1.0904269774096735 1.0715150284741313 1.0184187550822519 1.0 10.857686708633631 -4.768644109291962 4.711054401540174 1.1075122879282744 0.7494103202041862 0.6064430314090528 0.07833263663576667 0.11801161147697334 6.219307484313869 0.019273888122004333 0.14056285801539048 1.7035539455917147e-05 4.768644109291962 -0.3581019677240882 KS(ph)SPEMEDAR ddPTM_A459_Selumetinib_30min_R1 1 KSSPEMEDAR 10 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 KS(0.77)S(0.23)PEMEDAR 182.25 0.00026456 36510000.0 5740.5 6824.2 7324.1 7698.8 6825.7 6022.6 6014.1 5597.8 3378.0 5398.6 True False 5874.242480931438 6025.219491515494 6329.527448401533 6354.3491043745535 6208.316640175214 5962.018112083281 5560.45159502031 5449.328159783005 5732.219280641539 6091.56289681712 0.9643243582038308 0.9891089681867536 1.0390646137313546 1.0431393735907644 1.0191664676759882 0.9787337360004069 0.9128119809656207 0.8945697930214777 0.9410096189988713 1.0 12.572596708887406 -7.04324976886798 3.6376145396466564 0.9288194619703685 1.0126315196901727 0.5107931663609497 0.03357255223908813 0.17971136581135114 4.887023159576979 0.013662952576120319 0.01082864372066044 9.052118510934828e-08 7.04324976886798 0.08381205771980427 KS(ph)SPSTGSLDSGNESK ddPTM_A459_Selumetinib_30min_R1 1 KSSPSTGSLDSGNESK 16 1 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 KS(0.472)S(0.472)PS(0.049)T(0.007)GS(0.001)LDSGNESK 159.04 0.00053952 0.0 1201.2 1110.4 1517.1 1608.8 995.87 1043.4 1003.5 972.1 481.83 834.51 True False 1229.185622871673 980.3938517890451 1311.0861528337907 1327.8532809162193 905.7937343351289 1032.9043433314007 927.8051870775148 946.3167501741855 817.6303185291625 941.6274873157582 1.3053841773200991 1.0411695335952817 1.3923618102645097 1.410168350863941 0.9619448736752806 1.0969352076539736 0.9853208403275845 1.0049799553662082 0.8683161117778464 1.0 9.879012624886983 -6.274602252152286 24.936742730371215 0.9919863339244476 1.277198783163155 0.6536044962222799 0.10720831813324273 512.5560088889155 971022.7084367812 0.03461733328260633 0.039486436933107966 5.313708765432019e-07 6.274602252152286 0.2852124492387075 KS(ph)SPSTGSLDSGNESK ddPTM_A459_Selumetinib_30min_R2 2 KSSPSTGSLDSGNESK 16 1 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 KS(0.483)S(0.483)PS(0.031)T(0.002)GSLDSGNESK;KS(0.453)S(0.453)PS(0.089)T(0.004)GSLDSGNESK 61.276 0.035789 18456400.0 52832.0 50525.0 58267.0 56482.0 59277.0 47132.0 46054.0 49280.0 40003.0 49475.0 True False 49895.80894325292 54400.10503651924 54518.16465631285 48789.05416311536 51830.093316896346 53624.00517830276 48195.60225426974 49423.39664125682 48004.7177772082 48046.528198512315 1.0384893729906977 1.1322380008760686 1.1346951944386467 1.0154543104870175 1.0787479399708464 1.1160849116245437 1.0031027019297107 1.0286569809384716 0.9991297930803373 1.0 15.55214456639137 -7.2719204943404705 24.877633974099915 1.0101104448650775 1.0867393016468847 0.523955373489693 0.03649713852926942 594.4838040393502 1411043.0489409526 0.015647446126199678 0.010664894488419676 5.3466223027549216e-08 7.2719204943404705 0.0766288567818072 KS(ph)SPSVKPAVDPAAAK ddPTM_A459_Selumetinib_30min_R1 1 KSSPSVKPAVDPAAAK 16 2 H3BV90;Q6FI81-3;Q6FI81;H3BPG7;H3BT65 H3BV90 CIAPIN1 Anamorsin 1 KS(0.5)S(0.5)PSVKPAVDPAAAK 104.84 0.0042643 155980000.0 5232.6 6374.3 6682.7 6703.5 5682.4 5472.4 6324.3 5423.2 3000.5 5078.2 True False 5354.509399132797 5627.993992668326 5775.226045443525 5532.859565279635 5168.427923309206 5417.352624541646 5847.252959276859 5279.359118963731 5091.629352150663 5730.036435856836 0.934463412069406 0.98219165893083 1.007886443671441 0.965588897595253 0.901988666418724 0.9454307464157629 1.0204565057713275 0.9213482633246619 0.888585859644589 1.0 12.484328597407416 -6.009791983238638 24.662637843654466 0.9449201452953792 0.9774409633825603 0.089609457188088 0.04136261161358924 936.3508787479934 2358357.3136010733 0.012279538760589008 0.017068772922415612 9.777054065340182e-07 6.009791983238638 0.0325208180871811 KS(ph)SPSVKPAVDPAAAK ddPTM_A459_Selumetinib_30min_R2 1 KSSPSVKPAVDPAAAK 16 2 H3BV90;Q6FI81-3;Q6FI81;H3BPG7;H3BT65 H3BV90 CIAPIN1 Anamorsin 1 KS(0.576)S(0.419)PS(0.004)VKPAVDPAAAK 78.08800000000002 0.030254000000000007 65013000.0 252070.0 219680.0 244390.0 268180.0 251740.0 186520.0 227450.0 232420.0 161980.0 205010.0 True False 238060.95851615997 236528.74961746694 228666.2134717127 231653.42136369555 220114.17061584577 212211.43694002027 238026.87568362494 233096.3037207977 194380.5260993468 199090.82862005054 1.1957404575902435 1.188044428047782 1.1485522213989299 1.1635564680168577 1.1055967376373557 1.0659026255047106 1.1955692652115122 1.1708038252512576 0.9763409366802477 1.0 17.603067237388096 -7.573372086478705 0.021328295180200733 1.5439791979543218e-05 2.216749216216224 0.5129726362919168 0.05384603205798725 229.44336309781812 4.010587383456535 203.9346569331462 211.44102586356794 2.6707172623753015e-08 7.573372086478705 2.2167337764242445 KS(ph)SSLESLQTAVAEVTLNGDIPFHRPRPR ddPTM_A459_Selumetinib_30min_R1 1 KSSSLESLQTAVAEVTLNGDIPFHRPRPR 29 3 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 KS(0.676)S(0.151)S(0.151)LES(0.019)LQT(0.001)AVAEVTLNGDIPFHRPRPR 52.059 0.010065 4701700.0 1910.0 1441.4 3268.8 2206.5 2442.7 1573.3 1265.4 1378.1 884.57 722.21 True False 1954.4992837869602 1272.6402179113206 2824.914914233138 1821.1761961347827 2221.758216293713 1557.4740304421045 1169.9498592206148 1341.5483113003243 1501.0506835633773 814.9126884211265 2.3984155745246216 1.561689044720889 3.4665246404573007 2.2348114368709453 2.7263757797148984 1.9112158303237032 1.4356751046389573 1.646247911416794 1.8419773122831435 1.0 9.670501683805993 -6.963670827310946 4.255932282016832 1.54554846049997 2.465545568839492 0.4820137072089624 0.48578157580900067 0.19814793117564652 8.036781816913543 0.17850558376753065 0.15182204032711974 1.0872493900301002e-07 6.963670827310946 0.919997108339522 KS(ph)SSYSSSSTTVK ddPTM_A459_Selumetinib_30min_R2 2 KSSSYSSSSTTVK 13 1 P55085 P55085 F2RL1 Proteinase-activated receptor 2;Proteinase-activated receptor 2, alternate cleaved 1;Proteinase-activated receptor 2, alternate cleaved 2 1 KS(0.729)S(0.222)S(0.047)YS(0.001)SSSTTVK;KS(0.535)S(0.401)S(0.061)Y(0.001)S(0.001)SSSTTVK 70.334 0.031411 20689000.0 133059.0 43042.0 74467.0 93994.0 39624.0 41720.0 118352.0 66601.0 67772.0 67892.0 True False 125664.11345737973 46343.18299815659 69675.87429353913 81191.8550513061 34646.07887694554 47466.55130354729 123855.6025100388 66794.79788361085 81328.29370789582 65931.78155539952 1.9059717558487301 0.7028959616268899 1.0567873740070808 1.2314524670182654 0.5254837357585127 0.7199343045760606 1.8785417227952275 1.0130895344832473 1.2335218583401892 1.0 16.00868644477716 KS(ph)STSGSDFDTK ddPTM_A459_Selumetinib_30min_R1 1 KSSTSGSDFDTK 12 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 KS(0.531)S(0.212)T(0.212)S(0.036)GS(0.008)DFDTK 83.37 0.017743000000000002 16344000.0 2345.2 4319.8 3638.4 4398.3 3578.4 3893.5 3375.6 3481.5 2109.2 2832.6 True False 2399.8385970351724 3814.035807779465 3144.3252643006144 3630.219471316389 3254.734351817831 3854.3349250151514 3120.975774288849 3389.1593104942144 3579.1583501270393 3196.191801860516 0.7508431113671641 1.1933062983139182 0.9837723951579783 1.135795251462451 1.0183163444456733 1.2059147773207877 0.9764669856396342 1.0603741954789356 1.1198196391229078 1.0 11.642138270928656 -4.748469741659283 24.99970989543724 1.0769355454315968 0.7508423361423535 0.5999095344596971 0.07992760175358167 409.2950413450244 788892.7831806082 0.018172602238077974 0.3315196820640357 1.7845563185384036e-05 4.748469741659283 -0.32609320928924324 KS(ph)STVATLQGTPDHGDPR ddPTM_A459_Selumetinib_30min_R2 2 KSSTVATLQGTPDHGDPR 18 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 KS(0.419)S(0.419)T(0.154)VAT(0.008)LQGTPDHGDPR;KS(0.945)S(0.042)T(0.012)VAT(0.001)LQGTPDHGDPR 169.84 4.7083000000000005e-08 25198000.0 60397.0 38070.0 52531.0 73650.0 40604.0 28499.0 36922.0 42889.0 38317.0 46309.0 True False 57040.37652834735 40989.84658565632 49151.21265142825 63618.74294666353 35502.96251563437 32424.478561835913 38638.946159555046 43013.79988934384 45981.47066643222 44971.93884476821 1.26835484512323 0.9114538451887283 1.0929307010997644 1.4146319812063115 0.7894470069031634 0.7209935660936709 0.8591790158953775 0.9564586494217345 1.0224480386569204 1.0 15.456737462832233 -6.289022867751047 24.996867800049845 0.879110492745313 1.1476071239005652 0.45829859780666926 0.14806102641422042 726.9448079627567 658774.043821203 0.04807347242389997 0.05452246134508829 5.140165853560129e-07 6.289022867751047 0.26849663115525213 KS(ph)SVNGSSATSSG ddPTM_A459_Selumetinib_30min_R2 1 KSSVNGSSATSSG 13 1 R4GMX3;P35226 R4GMX3 COMMD3-BMI1;BMI1 Polycomb complex protein BMI-1 1 KS(0.358)S(0.358)VNGS(0.035)S(0.233)AT(0.016)SSG 87.831 0.04419 7812200.0 9221.3 6946.5 12794.0 11427.0 10973.0 10393.0 18239.0 45391.0 17912.0 30868.0 True False 8708.81706178865 7479.274213482053 11970.847969053959 9870.622887325499 9594.473640135355 11824.541411739388 19087.149639892865 45523.08029511545 21494.90050309612 29976.760635304272 0.29051895125492944 0.24950241637095208 0.3993376107142022 0.3292758349513141 0.32006372392471716 0.39445694468445575 0.6367315625629515 1.5186123960806472 0.7170521446463803 1.0 14.871556869977196 -7.544184927389605 5.383530062198394 1.0937818676169906 0.34147613645552444 0.7603693711260042 0.18766014763199274 0.07709580882179182 6.6090213966675835 0.08345896379600382 0.04883092827113574 2.856374008768837e-08 7.544184927389605 -0.7523057311614662 down KS(ph)T(ph)T(ph)SAS(ph)TS(ph)EEEK ddPTM_A459_Selumetinib_30min_R1 1 KSTTSASTSEEEK 13 1 Q8N5F7 Q8N5F7 NKAP NF-kappa-B-activating protein 5 KS(0.738)T(0.738)T(0.738)S(0.738)AS(0.819)T(0.256)S(0.973)EEEK 50.108 0.031376999999999995 4944300.0 784.85 807.13 618.54 814.06 751.69 753.12 708.22 790.06 354.16 612.09 True False 803.1354779477458 712.6308443754433 534.5456653970163 671.8997027987676 683.6997722216487 745.5442965782482 654.7983952088072 769.1050423234409 600.9836531770303 690.6577137614919 1.1628560167288544 1.031814790707658 0.7739661119337233 0.9728403656558565 0.9899256297277148 1.0794700207108823 0.9480794642003112 1.113583511772721 0.8701613566348596 1.0 9.431827085620398 -4.849192630644197 4.294955643646863 0.9727467198403082 1.1651759802190178 0.2910157369539469 0.0914298189480552 0.26352959718472463 8.027284863166132 0.02304705719354946 0.12538102641800225 1.4151659460684386e-05 4.849192630644197 0.19242926037870955 KS(ph)TAALEEDAQILK ddPTM_A459_Selumetinib_30min_R1 4 KSTAALEEDAQILK 14 1 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E9PDQ5;Q15052-2;Q15052 B1ALK7 ARHGEF7;ARHGEF6 Rho guanine nucleotide exchange factor 7;Rho guanine nucleotide exchange factor 6 1 KS(0.766)T(0.234)AALEEDAQILK;KS(0.743)T(0.257)AALEEDAQILK;KS(0.81)T(0.19)AALEEDAQILK;KS(0.652)T(0.348)AALEEDAQILK 129.17 0.00055177 56141500.0 16243.6 18560.199999999997 19699.6 21036.9 14758.6 18874.5 16202.1 14580.900000000001 9528.7 12569.400000000001 True False 16622.044275456476 16387.1631555971 17024.50252215711 17363.200326520637 13423.68723584247 18684.639666674833 14979.962552614457 14194.167166561852 16169.507951287464 14182.804926324077 1.1719856799697663 1.1554247020052861 1.2003621716998083 1.2242430476000956 0.9464761946296926 1.3174149798813843 1.0562059219196347 1.0008011278655244 1.1400782874250746 1.0 13.79185526143006 -7.677639131079605 0.40755166805364557 1.0021274402256617 1.1892372559455455 0.217742052914639 0.09826179017788554 1.6970640650928983 0.7444496676031963 0.11248340002665819 0.1002517042818145 2.1006846834765562e-08 7.677639131079605 0.18710981571988383 KS(ph)TAALEEDAQILK ddPTM_A459_Selumetinib_30min_R2 1 KSTAALEEDAQILK 14 1 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E9PDQ5;Q15052-2;Q15052 B1ALK7 ARHGEF7;ARHGEF6 Rho guanine nucleotide exchange factor 7;Rho guanine nucleotide exchange factor 6 1 KS(0.914)T(0.086)AALEEDAQILK 120.59 0.0010495 7607000.0 41966.0 45074.0 41343.0 51121.0 39887.0 46923.0 55010.0 37193.0 41340.0 55147.0 True False 39633.69772320852 48531.030864246735 38683.03639085489 44158.231611356176 34876.038465695696 53386.21732541585 57568.074000247085 37301.22547236738 49609.15513610947 53554.7628208865 0.7400592521670412 0.906194487809766 0.7223080516709599 0.8245435006227746 0.6512219759489617 0.9968528383547445 1.0749384549191838 0.6965062210642413 0.9263257369288874 1.0 15.708727264375955 -6.775293268351394 24.999928416263064 0.9284571497571943 0.7770015266093244 0.36512520713310803 0.1114390555328173 305.68545708763827 551618.9657099015 0.039836772474365165 0.035310711848496525 1.6776707458566902e-07 6.775293268351394 -0.15145562314786987 KS(ph)TGSPTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R2 1 KSTGSPTQETQAPFIAK 17 1 O15231-3;O15231-2;H0Y704 O15231-3 ZNF185 Zinc finger protein 185 1 KS(0.726)T(0.09)GS(0.09)PT(0.09)QET(0.003)QAPFIAK 58.09 0.035248 5051700.0 19708.0 26137.0 24521.0 28773.0 25157.0 15550.0 15342.0 12402.0 11801.0 27289.0 True False 18612.708257374852 28141.62385629893 22943.345556446144 24854.067763806488 21996.5527535665 17691.871351154372 16055.43339959627 12438.087766738374 14161.529747489796 26501.09566466302 0.7023373106113998 1.0619041647332121 0.8657508295794413 0.9378505733612854 0.8300242764263159 0.6675901847614925 0.6058403623290504 0.46934239716448845 0.5343752547700511 1.0 14.693764387425242 -6.74285570166644 2.51673069611025 0.6099639052994628 0.9020048543129029 0.32921682301485156 0.15688310254770024 0.26976877916970193 3.502650180929866 0.05629682918332461 0.05270841291119903 1.8077746759890757e-07 6.74285570166644 0.29204094901344013 KS(ph)VSNGALR ddPTM_A459_Selumetinib_30min_R2 1 KSVSNGALR 9 1 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 KS(0.999)VS(0.001)NGALR 73.9 0.03238 23686000.0 118600.0 127540.0 117650.0 133860.0 150440.0 114520.0 118270.0 123310.0 100140.0 144830.0 True False 112008.68679341671 137321.90789426374 110080.52708763449 115628.03707862021 131540.38224933596 130294.0904909454 123769.78934755898 123668.81168493052 120170.79814537997 140648.38158646887 0.7963738048742152 0.9763490083946679 0.782664726362019 0.8221071282468582 0.9352427718371333 0.9263817259841146 0.8799944084068032 0.8792764643999866 0.8544058366679497 1.0 17.10173342637411 -6.25996709358466 24.99927335396536 0.905577810997173 0.8493926956706483 0.2192825714997083 0.06190253540634344 257.14874424431235 4366351.423923719 0.01846384514570072 0.022600649574184378 5.495825140490184e-07 6.25996709358466 -0.056185115326524704 KSAEPSANTTLVS(ph)ETEEEGSVPAFGAAAK ddPTM_A459_Selumetinib_30min_R1 4 KSAEPSANTTLVSETEEEGSVPAFGAAAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 KSAEPSANTTLVS(0.999)ET(0.001)EEEGSVPAFGAAAK;KSAEPSANTTLVS(0.832)ET(0.166)EEEGS(0.002)VPAFGAAAK;KSAEPSANTTLVS(0.871)ET(0.127)EEEGS(0.002)VPAFGAAAK;KSAEPSANTTLVS(0.93)ET(0.069)EEEGSVPAFGAAAK 158.88 4.529200000000001e-19 203152000.0 12755.659999999998 15815.7 11287.470000000001 10871.589999999998 14193.399999999998 12717.42 16889.800000000003 15482.400000000001 8690.97 14858.859999999999 True False 13052.842059806262 13963.990491480545 9754.69357163459 8973.07089151911 12909.609476048288 12589.49430129349 15615.788787944011 15071.756458077172 14747.941326665832 16766.139418552957 0.7785240080589059 0.8328685657968685 0.5818091647764965 0.5351900439041889 0.7699810405824768 0.750888083834153 0.931388460879909 0.8989401842501187 0.8796265472029988 1.0 14.033262910855171 -7.090839377820617 2.0056622514932565 0.9236991346793995 0.6892420844157239 0.5963867245989838 0.08890021024082337 0.26619569907806323 2.1178555386103803 0.045172833156998105 0.03279849497953428 8.11261044219504e-08 7.090839377820617 -0.23445705026367558 KSAEPSANTTLVS(ph)ETEEEGSVPAFGAAAK ddPTM_A459_Selumetinib_30min_R2 6 KSAEPSANTTLVSETEEEGSVPAFGAAAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 KSAEPSANTTLVS(0.871)ET(0.128)EEEGS(0.001)VPAFGAAAK;KSAEPSANT(0.001)T(0.005)LVS(0.754)ET(0.237)EEEGS(0.003)VPAFGAAAK;KSAEPSANT(0.002)T(0.008)LVS(0.734)ET(0.251)EEEGS(0.006)VPAFGAAAK;KSAEPSANTTLVS(0.959)ET(0.041)EEEGSVPAFGAAAK;KSAEPSANTTLVS(0.839)ET(0.158)EEEGS(0.003)VPAFGAAAK;KSAEPSANTT(0.002)LVS(0.44)ET(0.44)EEEGS(0.117)VPAFGAAAK 126.86 6.1611e-14 62430500.0 412584.0 347657.0 413968.0 444020.0 435638.0 386097.0 393983.0 429822.0 369977.0 397697.0 True False 389654.2329846128 374321.174006555 387333.74957428005 383543.7100227764 380909.2597868662 439278.3571103957 412303.99016250425 431072.71085913724 443982.7380211036 386214.4542691007 1.0089063955983257 0.969205501940487 1.0028981186302248 0.993084815400349 0.9862636045243972 1.1373949168777664 1.0675519406511527 1.1161485700345666 1.149575664798273 1.0 18.55904263331918 -6.7506906572731795 24.999984937160633 1.0997321114752432 0.9914590742579371 0.6163009234580108 0.04014293151292761 128.76848661967298 299496.5393456958 0.012518797028921289 0.012397753124986626 1.7754536648589653e-07 6.7506906572731795 -0.10827303721730608 KSAEPSANTTLVSET(ph)EEEGSVPAFGAAAK ddPTM_A459_Selumetinib_30min_R2 3 KSAEPSANTTLVSETEEEGSVPAFGAAAK 29 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 KSAEPSANTTLVS(0.162)ET(0.793)EEEGS(0.045)VPAFGAAAK;KSAEPSANTTLVS(0.054)ET(0.935)EEEGS(0.012)VPAFGAAAK;KSAEPSANTTLVS(0.388)ET(0.611)EEEGS(0.001)VPAFGAAAK 125.16 1.5927e-13 34907000.0 360282.0 292011.0 333464.0 381886.0 363981.0 318476.0 354631.0 366437.0 311573.0 352177.0 True False 340258.9687631177 314407.3047366448 312009.2892881512 329872.4680099057 318254.4527485748 362343.17816271674 371122.0441879954 367503.2710030889 373896.30607699667 342008.73494426487 0.9948838552868179 0.9192961249597379 0.9122845629629824 0.9645147456940334 0.9305448084547865 1.0594559177611813 1.0851244610710744 1.074543523173403 1.0932361307611875 1.0 18.383673646623556 -6.783895257283147 7.335772241888873 1.0690192111652652 0.9421726527911252 0.7668138086366754 0.032477094096759154 0.07471497031688766 16.275722095160997 0.010923600275556784 0.009875970166369187 1.6447683590012554e-07 6.783895257283147 -0.12684655837414005 KSAS(ph)PEVSEGHENQHGQESEAK ddPTM_A459_Selumetinib_30min_R2 1 KSASPEVSEGHENQHGQESEAK 22 1 O60930 O60930 RNASEH1 Ribonuclease H1 1 KS(0.158)AS(0.683)PEVS(0.158)EGHENQHGQESEAK 69.986 0.0020702 11668000.0 77934.0 66504.0 79668.0 97557.0 99478.0 74287.0 64891.0 71007.0 65205.0 93684.0 True False 73602.7402745207 71604.6429559362 74542.24761596 84269.56830478815 86980.6842953965 84519.35993975589 67908.56007907707 71213.61861415829 78247.82197992296 90979.09949973578 0.8090071310799735 0.7870449735122313 0.8193337593561969 0.9262519498231886 0.9560512774216797 0.9289975434412971 0.7464193474378618 0.7827470155864217 0.8600637114478167 1.0 16.473247534626424 -5.576099654637797 8.404933093939688 0.8755987957402946 0.7992670722844271 0.199314544129646 0.07291223687329144 0.49945517065027795 71.2503854239778 0.02166859234585305 0.03769080597291213 2.653996497348707e-06 5.576099654637797 -0.07633172345586758 KSDASDMNSDT(ph)SPSCR ddPTM_A459_Selumetinib_30min_R1 3 KSDASDMNSDTSPSCR 16 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 KSDASDMNS(0.068)DT(0.464)S(0.464)PS(0.004)CR;KSDASDMNS(0.206)DT(0.641)S(0.127)PS(0.026)CR;KSDASDMNS(0.164)DT(0.628)S(0.164)PS(0.043)CR 146.15 0.00044297 104711000.0 12097.3 13025.2 16261.699999999999 16747.7 14073.3 12495.400000000001 11927.8 11175.9 6467.799999999999 9074.4 True False 12379.143552751819 11500.203528748803 14053.450459124146 13823.028588264884 12800.372499842924 12369.707620915451 11028.07644287312 10879.478827560622 10975.38421057826 10239.187632141156 1.208996650661354 1.1231558539516626 1.3725161569468547 1.3500122358217101 1.2501355536900332 1.2080750998337524 1.0770460352006457 1.062533398002159 1.0718999011333827 1.0 13.321813637311896 -7.196434937616547 2.1484962053603534 1.0495075400641807 1.2645184201074167 0.6847316444920142 0.06729833324340817 0.21399825143713577 1.9335118717514532 0.03546696804903768 0.02410322718107757 6.361581016090895e-08 7.196434937616547 0.21501088004323599 KSDASDMNSDT(ph)SPSCR ddPTM_A459_Selumetinib_30min_R2 1 KSDASDMNSDTSPSCR 16 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 KSDASDMNS(0.027)DT(0.464)S(0.464)PS(0.044)CR 129.06 0.001126 34799000.0 60855.0 58930.0 50615.0 76543.0 67462.0 47446.0 39641.0 50835.0 34777.0 68429.0 True False 57472.922721866606 63449.74151018458 47358.4860054452 66117.71135595997 58986.820442067925 53981.255828094545 41484.38504715135 50982.92143381274 41733.371750567996 66453.27697010619 0.8648621308430076 0.9548022972400181 0.7126583994759096 0.9949503526470609 0.8876435163401042 0.8123189448185957 0.6242639481242284 0.7671995085621927 0.6280107415822643 1.0 16.020052723549817 -6.992409352751049 5.254146828490573 0.7327679586743717 0.8817106917978357 0.19510062619855995 0.11939028130566377 0.23788354712508844 20.338118815590086 0.041555625325026435 0.03489403228477538 1.0176317471708279e-07 6.992409352751049 0.14894273312346396 KSDASDMNSDTS(ph)PSCR ddPTM_A459_Selumetinib_30min_R1 2 KSDASDMNSDTSPSCR 16 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 KSDASDMNS(0.011)DT(0.146)S(0.422)PS(0.422)CR;KSDASDMNS(0.015)DT(0.242)S(0.738)PS(0.005)CR 102.24 0.0025899 48944000.0 5880.3 5793.2 7777.700000000001 7876.4 7032.4 6217.4 6939.799999999999 5320.4 3422.6000000000004 4240.8 True False 6017.299548927987 5114.929450814385 6721.53105984798 6500.93459833945 6396.320661671058 6154.858600947528 6416.3252987349615 5179.285708905189 5807.902223186423 4785.14798889009 1.2574949746379094 1.0689177142880355 1.4046652424237838 1.3585650043494963 1.3367027888210992 1.2862420588114645 1.3408833569269027 1.0823668820546797 1.2137351314255924 1.0 12.22434782787628 -8.359516879468321 1.0011800709118175 1.0150945952959793 1.2916012411280176 0.4232530366790468 0.10054992394013197 0.5161239526719588 1.1121087086708101 0.09864348587724403 0.033584918420867846 4.370016940525976e-09 8.359516879468321 0.2765066458320382 KSDASDMNSDTS(ph)PSCR ddPTM_A459_Selumetinib_30min_R2 2 KSDASDMNSDTSPSCR 16 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 KSDASDMNS(0.013)DT(0.067)S(0.718)PS(0.202)CR;KSDASDMNS(0.03)DT(0.03)S(0.892)PS(0.047)CR 125.23 0.00062758 45186000.0 59340.0 65744.0 69921.0 63092.0 68691.0 51650.0 50373.0 47600.0 39770.0 70888.0 True False 56042.1203568411 70786.35339972138 65422.358984228675 54498.76076022938 60061.42247466859 58764.31866798219 52715.44431220588 47738.50811939579 47725.1112666443 68841.27925085688 0.8140772653660926 1.0282544742054642 0.950336189219121 0.7916581643062802 0.8724623238886281 0.8536203758481251 0.7657534096673504 0.6934575975184478 0.6932629925823213 1.0 16.07098628622041 -6.3770590366944715 0.9692583488992135 0.7713830391344956 0.9328569726645906 0.17741628662879116 0.10163891132794571 0.7507161912262538 1.5126769853972089 0.049736110733946334 0.06877909274472047 4.197019270868597e-07 6.3770590366944715 0.16147393353009498 KSDGACDS(ph)PSSDKENSSQIAQDHQK ddPTM_A459_Selumetinib_30min_R2 1 KSDGACDSPSSDKENSSQIAQDHQK 25 2 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 KS(0.006)DGACDS(0.684)PS(0.14)S(0.026)DKENS(0.072)S(0.072)QIAQDHQK 50.426 0.014385 11047000.0 43772.0 43369.0 45389.0 48484.0 37797.0 35864.0 45537.0 43561.0 29495.0 54544.0 True False 41339.32747319933 46695.26284668585 42468.721155806634 41880.395560434925 33048.60295053278 40803.94045902257 47654.56072985369 43687.75529808825 35394.82415915699 52969.17299766867 0.7804412478748497 0.881555444498653 0.8017629642372519 0.7906560210460187 0.6239214448748776 0.7703337271438705 0.8996659383742146 0.8247769943474684 0.6682155328480364 1.0 15.69286536370908 -10.083993292501427 9.47598300475183 0.9999999999954543 0.7857841318647631 0.3983235919727691 0.08014354510499445 0.0 0.0 0.08165030572761628 0.019803107934055098 8.241508435834747e-11 10.083993292501427 -0.21421586813069116 KSDIDEIVLVGGSTR ddPTM_A459_Selumetinib_30min_R1 1 KSDIDEIVLVGGSTR 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 117.07 0.0029548 11787000.0 1811.7 2298.2 3011.7 2179.1 2555.3 2439.1 2241.9 2114.4 1573.9 2208.0 False True 1853.9090850454631 2029.125675595805 2602.7276820839274 1798.56109177308 2324.1735661748567 2414.5648685256083 2072.791678035955 2058.319243460855 2670.7933468921597 2491.418307741302 0.7441179505204009 0.814446000212382 1.0446771118269325 0.7219024947294538 0.9328716735175362 0.9691527356217557 0.8319725642199081 0.826163650265101 1.071997158643936 1.0 11.282751554269037 -1.5228787452815398 0.11375940791354987 1.0441018112496039 0.3051468538535004 0.24611725799887474 0.10259186674899812 174.9598624470751 1.3868125466713752 0.8560707568769336 20.35355707014285 0.029999999999916954 1.5228787452815398 -0.7389549573961035 KSDVEAIFSK ddPTM_A459_Selumetinib_30min_R2 1 KSDVEAIFSK 10 1 B4DY08;G3V4W0;G3V5X6;G3V3K6;G3V251;B4DSU6;G3V4M8;G3V2H6;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V576;G3V555;G3V575;A0A0G2JNQ3;B2RXH8;O60812;A0A0G2JPF8;P0DMR1;B7ZW38 B4DY08;G3V2Q1;A0A0G2JNQ3;O60812 HNRNPC;HNRNPCL2;HNRNPCL1;HNRNPCL4;HNRNPCL3 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3 0 93.345 0.034299 2846500.0 32731.0 27448.0 28433.0 30484.0 30879.0 27693.0 27521.0 28440.0 25428.0 26534.0 False True 30911.94205257441 29553.17334076952 26603.651735509706 26332.026612166865 26999.70395823747 31507.45937797544 28800.78103182693 28522.75569150455 30514.310517682443 25767.89447638861 1.1996301087347025 1.1468990362347766 1.032434053154281 1.0218928300989114 1.0478040409152398 1.2227409347258098 1.1177002086149253 1.1069106060504963 1.184198831054785 1.0 14.653287037330092 KSEAGHASS(ph)PDSEVTSLCQK ddPTM_A459_Selumetinib_30min_R2 1 KSEAGHASSPDSEVTSLCQK 20 1 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 KSEAGHAS(0.412)S(0.564)PDS(0.022)EVT(0.002)S(0.001)LCQK 80.786 0.0020333 6933600.0 37752.0 33391.0 50539.0 65124.0 83118.0 45346.0 34928.0 37569.0 39874.0 63543.0 True False 35653.89497322995 35951.98233101262 47287.37576270265 56253.99885483386 72675.97375565206 51591.99988999658 36552.22120851901 37678.31957011722 47849.914172647084 61708.34848545865 0.5777807354807375 0.582611319430864 0.7663043481684776 0.9116108312004155 1.1777332490558856 0.8360619131162463 0.5923383481431594 0.6105870679555779 0.7754204308987906 1.0 15.913178063475181 -5.337817600405883 3.580980865759643 0.8306367991383696 0.5759491582699089 0.28665149710808024 0.16266920084872202 0.35019402789865245 8.601371689180466 0.049798075091468545 0.12020393574349673 4.593909121846654e-06 5.337817600405883 -0.25468764086846074 KSEAPAEVTHFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 KSEAPAEVTHFSPK 14 1 Q6PID6 Q6PID6 TTC33 Tetratricopeptide repeat protein 33 1 KSEAPAEVT(0.01)HFS(0.99)PK 83.229 0.014486 29292000.0 4585.5 4969.4 6532.6 7052.3 4746.0 5047.4 5297.3 5140.4 2809.3 4956.2 True False 4692.333228170211 4387.580337788618 5645.508801003244 5820.748193066538 4316.725137974355 4996.627738672526 4897.720396119305 5004.059893627594 4767.176916846145 5592.376547476198 0.839058884596716 0.7845645407709007 1.0095008361965585 1.0408362426334477 0.7718945785083918 0.8934712632910012 0.8757851611994214 0.8948002429997123 0.8524420479156648 1.0 12.449245788595618 -10.87096992276559 5.297151886315865 1.0000397948485922 0.8869974782333884 0.15267075856260615 0.08132362384647829 3.989097770408531e-05 4.9092777898681465e-06 0.08218416602998599 0.019925575684379332 1.3459535653694487e-11 10.87096992276559 -0.11304231661520381 KSEAPAEVTHFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KSEAPAEVTHFSPK 14 1 Q6PID6 Q6PID6 TTC33 Tetratricopeptide repeat protein 33 1 KSEAPAEVTHFS(1)PK 84.365 0.013329 13138000.0 69205.0 69204.0 74001.0 76867.0 75434.0 58968.0 54148.0 58507.0 49796.0 74913.0 True False 65358.863149565 74511.72427406796 69239.85622619693 66397.581997029 65957.30653148376 67090.30674179234 56665.989292226506 58677.24568364472 59756.59141649028 72750.06704265096 0.8984027892544382 1.024215197360357 0.9517497239638817 0.9126806983985636 0.9066288075420628 0.9222026792423369 0.7789132243549014 0.8065593348421822 0.8213956886315578 1.0 16.15066095708316 -6.681669151398654 1.3436781345209754 0.840066524740902 0.9560334428310222 0.2531929285791875 0.06599968202233604 0.4695072932686893 1.7746910987523574 0.029463982631572953 0.02856813248381459 2.0812816183466372e-07 6.681669151398654 0.11596691809012016 KSEDS(ph)LLRNSDEEESASESELWK ddPTM_A459_Selumetinib_30min_R1 1 KSEDSLLRNSDEEESASESELWK 23 2 Q70Z53 Q70Z53 FRA10AC1 Protein FRA10AC1 1 KS(0.054)EDS(0.699)LLRNS(0.239)DEEES(0.006)AS(0.001)ESELWK 61.345 0.01059 6357300.0 513.16 433.55 751.11 658.25 463.45 529.82 423.91 409.2 247.47 326.12 True False 525.1156295644585 382.78976444807296 649.1133875519004 543.2989943828323 421.5310293287432 524.4904918380703 391.93412740810095 398.34668673107353 419.9385155063237 367.98067867780543 1.4270195692101444 1.040244193862238 1.7639876905609155 1.47643348105929 1.1455248977836283 1.4253207361936002 1.0650943109740514 1.0825206588627871 1.141197187350185 1.0 8.523486207395322 -7.2656869797864685 24.81507228609872 1.0790797413498487 1.375535547781845 0.3987507659346442 0.18489171059890602 374.5845372340151 2188361.8229649016 0.0769898498624942 0.053970018284231064 5.423916814360927e-08 7.2656869797864685 0.2964558064319962 KSFSKEELMS(ph)SDLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R1 1 KSFSKEELMSSDLEETAGSTSIPK 24 2 O00567 O00567 NOP56 Nucleolar protein 56 1 KS(0.033)FS(0.028)KEELMS(0.657)S(0.247)DLEET(0.018)AGS(0.007)T(0.007)S(0.003)IPK 45.135 0.028238 38068000.0 2481.7 3604.8 6881.8 7786.8 4998.0 4569.8 3070.2 3007.0 1786.9 2050.2 True False 2539.518781452406 3182.7483401739473 5947.2893590215435 6426.981556339143 4545.931782468571 4523.831961046421 2838.6123421677985 2927.244591887437 3032.238789987675 2313.3631406391396 1.097760544741274 1.3758100854389046 2.5708412373936316 2.778198305071761 1.9650748741559936 1.955521760321888 1.2270500434201361 1.265363202371545 1.3107491585389068 1.0 11.17577603575393 -7.2519500295777926 5.238279024887444 1.2182541318385778 1.9999713643631456 0.3829887653384515 0.4685267616857783 0.21633340074823937 19.8808987316831 0.21367585882000067 0.1548010859647089 5.598220115535249e-08 7.2519500295777926 0.7817172325245678 KSFSKEELMSS(ph)DLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R1 1 KSFSKEELMSSDLEETAGSTSIPK 24 2 O00567 O00567 NOP56 Nucleolar protein 56 1 KSFSKEELMS(0.192)S(0.784)DLEET(0.017)AGS(0.002)T(0.002)S(0.003)IPK 76.796 0.0004237 26865000.0 1503.7 2220.5 4143.6 4850.4 2640.9 2607.4 2009.3 1768.8 1012.2 1151.4 True False 1538.7332843091376 1960.5228277175563 3580.9218791655762 4003.368693284455 2402.0310612887647 2581.17192332978 1857.7368833032892 1721.8856781278662 1717.6294718369936 1299.1934055857498 1.1843758424985151 1.5090307719300975 2.756265436516047 3.0814262726953343 1.8488633416406492 1.9867495572501321 1.4299155732442441 1.3253497675748613 1.3220737300945498 1.0 10.343400499520042 -7.2925376139342255 1.7704662449482618 1.2232752257629165 2.1368840170084327 0.36175404253019716 0.5212605843603039 0.46111471233225565 2.816723415775448 0.31906719236611797 0.19249755103361124 5.0987343588915815e-08 7.2925376139342255 0.9136087912455162 KSFT(ph)PDHVVYAR ddPTM_A459_Selumetinib_30min_R1 1 KSFTPDHVVYAR 12 1 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 KS(0.004)FT(0.996)PDHVVYAR 81.632 0.021027 14150000.0 4664.7 4781.4 6870.6 7192.8 6368.6 4982.5 5133.7 4209.9 2455.0 4193.1 True False 4773.378434073838 4221.591465187443 5937.610257504342 5936.71250557818 5792.561254467656 4932.38057374804 4746.460875834418 4098.239776317562 4165.9556938943115 4731.325229252747 1.0088882507085088 0.8922640614697692 1.25495711450851 1.2547673681092113 1.2242999527180078 1.0424945094140246 1.003199028992573 0.8661927848415586 0.8805050365460232 1.0 12.208028619154277 -7.318767589915293 2.234585421103447 0.9092526523976333 1.1262002162035198 0.3868974740243045 0.1128250048370336 0.3543523070697646 3.4592043708245015 0.06349789091804235 0.03953175979021955 4.7999024381672225e-08 7.318767589915293 0.21694756380588653 KSFT(ph)PDHVVYAR ddPTM_A459_Selumetinib_30min_R2 1 KSFTPDHVVYAR 12 1 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 KS(0.058)FT(0.942)PDHVVYAR 80.53399999999998 0.022187 11733000.0 58571.0 65884.0 68046.0 77070.0 67523.0 58182.0 51091.0 41218.0 47888.0 60691.0 True False 55315.8582982902 70937.09094955039 63667.99444288303 66572.93304683428 59040.15707672097 66196.04237638999 53466.83273489588 41337.93755599275 57466.93810251602 58938.693135844595 0.9385321484953133 1.2035742086450973 1.0802410276749457 1.1295284897714637 1.001721516638357 1.1231338676583535 0.9071601335248998 0.7013718044394908 0.9750290521383566 1.0 15.846927451084678 -7.344086594462593 5.160945715008499 0.8663339550312262 1.083668613888121 0.43103999304868235 0.10166477800707678 0.18158445864873662 8.323780101088607 0.04123255722828029 0.027466551874249828 4.5280728515079133e-08 7.344086594462593 0.21733465885689485 KSGIPTSEPGS(ph)Q ddPTM_A459_Selumetinib_30min_R2 1 KSGIPTSEPGSQ 12 1 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 KSGIPTSEPGS(1)Q 122.1 0.006510800000000001 2974800.0 20608.0 18061.0 17844.0 22162.0 24632.0 17492.0 17520.0 21721.0 17017.0 17655.0 True False 19462.689860360326 19446.22062473178 16695.936467078227 19143.4973684176 21537.50794712605 19901.36422343359 18334.714715221387 21784.20451389487 20420.875494706717 17145.254276801108 1.135164841894173 1.1342042708018663 0.9737934589671939 1.1165478831259024 1.2561789752087849 1.1607506020112934 1.0693754912710576 1.2705675962689356 1.191051189152545 1.0 14.065521680216095 -6.006031376352355 24.990778171165427 1.1689632809782826 1.0795027796726184 0.13246157125281444 0.08614907715894447 469.64291943292415 1945967.3497115818 0.024193700222405322 0.034556594686309325 9.86208232746107e-07 6.006031376352355 -0.08946050130566419 KSLPAPVAQRPDS(ph)PGGGLQAPGQK ddPTM_A459_Selumetinib_30min_R1 1 KSLPAPVAQRPDSPGGGLQAPGQK 24 2 Q5JVS0-2;Q5JVS0 Q5JVS0-2 HABP4 Intracellular hyaluronan-binding protein 4 1 KS(0.001)LPAPVAQRPDS(0.999)PGGGLQAPGQK 59.094 0.011413 52535000.0 2731.2 3130.3 3876.1 4163.9 3384.8 2659.5 2893.0 2838.8 1511.4 2560.3 True False 2794.831646009919 2763.8030207630095 3349.7469098932556 3436.753031083441 3078.6454376349775 2632.7478446327973 2674.778680832339 2763.5058022780363 2564.7354117115506 2888.9394444339027 0.9674247936884588 0.9566843036769107 1.1595074851247529 1.1896244615666853 1.0656663100248016 0.911319844278942 0.9258687252811112 0.9565814221556155 0.8877774910280679 1.0 11.496324248297908 -6.753376447173767 22.900205737775757 0.9329432791088541 1.073474449487846 0.4457761310492515 0.07311147763771994 63.84760222997255 181337.74953029986 0.02695647721928703 0.02644019312734597 1.7645076794484257e-07 6.753376447173767 0.140531170378992 KSLPAPVAQRPDS(ph)PGGGLQAPGQK ddPTM_A459_Selumetinib_30min_R2 2 KSLPAPVAQRPDSPGGGLQAPGQK 24 2 Q5JVS0-2;Q5JVS0 Q5JVS0-2 HABP4 Intracellular hyaluronan-binding protein 4 1 KSLPAPVAQRPDS(1)PGGGLQAPGQK;KS(0.007)LPAPVAQRPDS(0.993)PGGGLQAPGQK 67.214 0.00091853 172462000.0 724560.0 748840.0 763000.0 775840.0 793590.0 538740.0 496930.0 499420.0 448200.0 723390.0 True False 684291.8558434919 806273.620099892 713909.4106915874 670169.2536013506 693892.1294153857 612946.544805203 520038.2296481146 500873.2295165685 537852.5237543356 702503.8511070604 0.9740755936997801 1.1477141638857966 1.0162355830029304 0.9539723555184011 0.9877413886370818 0.87251698882401 0.740263884430808 0.7129828950079823 0.7656221711905857 1.0 19.422146608607143 -6.786087207983113 1.7443382392441276 0.7802158274555846 1.0332233869455496 0.558090592869648 0.08852760587906794 0.23516187410418685 1.479370912871362 0.03696903942289902 0.03311860046045177 1.63648787544507e-07 6.786087207983113 0.253007559489965 KSLS(ph)DSESDDSK ddPTM_A459_Selumetinib_30min_R1 4 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 KS(0.009)LS(0.97)DS(0.005)ES(0.016)DDSK;KS(0.007)LS(0.991)DS(0.001)ES(0.001)DDSK;KSLS(0.913)DS(0.005)ES(0.041)DDS(0.041)K;KSLS(0.823)DS(0.039)ES(0.039)DDS(0.099)K 174.47 0.00025409 865807000.0 20723.8 22255.9 24898.300000000003 26254.3 21029.899999999998 23361.1 21158.9 21964.1 15311.1 19906.300000000003 True False 21206.62421850481 19650.168881512804 21517.247616572124 21669.479359248315 19127.749258130396 23126.108544181683 19562.867137871883 21381.540718548335 25981.81842150108 22461.46750878203 0.9441335126573276 0.8748390493110008 0.9579626802282294 0.9647401422358508 0.8515805679505042 1.029590276554272 0.8709523155699045 0.9519209156832045 1.1567284466761871 1.0 14.455164568128513 -8.123238555690893 6.4375610623691815 1.0763717571318674 0.928094067149466 0.4875221162029447 0.060922896934188675 0.18077203764273753 8.595934735560085 0.03873563721986176 0.014370078491462322 7.529418630890116e-09 8.123238555690893 -0.14827768998240143 KSLSDS(ph)ESDDSK ddPTM_A459_Selumetinib_30min_R2 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 KS(0.071)LS(0.347)DS(0.53)ES(0.026)DDS(0.026)K 118.71 0.008000700000000001 204800000.0 24147.0 20912.0 19317.0 20873.0 18719.0 14527.0 21658.0 25302.0 15588.0 21233.0 True False 22805.006408099794 22515.88315732191 18074.165250759368 18030.061392066615 16367.35187001675 16527.962387023763 22665.139914512827 25375.624631028426 18706.035565110655 20619.948120040663 1.1059681758333553 1.091946644397159 0.8765378625367621 0.8743989697308249 0.7937629995348637 0.8015520839725163 1.0991851086416862 1.2306347466687217 0.9071815048326982 1.0 14.33175308242743 -10.108998431136992 10.637726022099756 1.0000000096566768 0.9738682359126711 0.002518452106459179 0.1410572484143389 0.0 0.0 0.15144101766503235 0.036729841875526976 7.780393616556856e-11 10.108998431136992 -0.02613177374400566 KSLSDSES(ph)DDSK ddPTM_A459_Selumetinib_30min_R2 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 KS(0.012)LS(0.012)DS(0.139)ES(0.832)DDS(0.005)K 62.055 0.045883 17553000.0 16498.0 13251.0 13174.0 14047.0 11427.0 10772.0 12866.0 10571.0 9932.6 15035.0 True False 15581.107206726738 14267.309091319468 12326.399182766665 12133.774367573415 9991.438101323854 12255.745221519937 13464.294493495347 10601.759859876745 11919.397540031961 14600.900484378632 1.0671333061544266 0.9771526836022155 0.8442218475466335 0.8310291807382173 0.6843028696766752 0.8393828335883973 0.9221550758393752 0.7261031517350228 0.8163467419550194 1.0 13.833769727030498 -5.106026397818727 2.0201030727872356 0.8179986188323973 1.0756335164750024 0.45844845144893487 0.0842748406069451 0.34620894863469265 2.3498629694562703 0.022813990768382166 0.12842327025550532 7.833820248340347e-06 5.106026397818727 0.25763489764260505 KSLSDSESDDS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 KS(0.012)LS(0.024)DS(0.11)ES(0.053)DDS(0.801)K 156.2 0.0017364999999999998 0.0 19585.0 18549.0 14930.0 16289.0 14351.0 11470.0 16164.0 14103.0 12563.0 17051.0 True False 18496.544104966844 19971.648655564462 13969.420054554908 14070.410099907687 12548.099080432195 13049.8883857068 16915.658028358375 14144.037395122661 15075.951039548703 16558.693326181583 1.117029208803647 1.206112599717426 0.8436305799846733 0.8497294939124468 0.7577952458719623 0.7880989235468914 1.0215575405103 0.8541759374671782 0.9104553567467513 1.0 14.015301211431654 -5.2636569870481935 24.998381777442486 0.8695602218280539 1.161570920203965 0.6589836542114889 0.08135582517426462 103.46890356525344 1166386.6442675053 0.021555957513230656 0.048697296455437834 5.449328799049743e-06 5.2636569870481935 0.2920106983759111 KSNLDEEVNVIPPHT(ph)PVR ddPTM_A459_Selumetinib_30min_R1 6 KSNLDEEVNVIPPHTPVR 18 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR 103.84 0.0010879000000000002 230389000.0 67322.29999999999 83444.70000000001 91999.8 96186.7 78912.0 78514.9 75805.70000000001 68572.20000000001 41725.9 60003.5 True False 68890.77860360779 73674.95573161145 79506.73247872788 79389.49849297869 71774.42353304509 77725.11139182541 70087.61501748087 66753.44250210296 70805.80476084097 67705.53370858479 1.0175058792110625 1.0881674169901678 1.1743018350750665 1.1725703076898193 1.0600968576951693 1.1479875740492123 1.0351829633180196 0.985937763808498 1.045790511977946 1.0 16.046986132517702 -7.407735259879602 5.069445513944273 1.0116363182157087 1.1122879304116398 0.4796477715128814 0.04804149955400882 0.20707965005424017 7.797652359216452 0.021724357522759856 0.014308315472066901 3.91079219818799e-08 7.407735259879602 0.1006516121959311 KSNLDEEVNVIPPHT(ph)PVR ddPTM_A459_Selumetinib_30min_R2 6 KSNLDEEVNVIPPHTPVR 18 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR;KSNLDEEVNVIPPHT(1)PVR 154.66 4.8864e-05 308881000.0 770031.0 803607.0 889431.0 966902.0 990633.0 748825.0 693401.0 684945.0 573321.0 871299.0 True False 727235.7596983269 865241.0728962333 832205.9777992506 835208.2796010152 866180.8261686151 851968.8465934519 725645.5204480161 686938.0765512519 688001.2199271771 846142.3339633251 0.859472136669914 1.0225715440137002 0.9835295368111453 0.9870777599424734 1.0236821766279318 1.006885972248706 0.8575927374406351 0.8118469540858906 0.8131034133519639 1.0 19.69054084136483 -7.2684597135605795 23.799198798458885 0.8549563345111957 0.9848417468022531 0.38907804088015663 0.06617932320590741 251.80342070813546 853617.1090170702 0.02620206522207922 0.01811645579294852 5.389398367063235e-08 7.2684597135605795 0.12988541229105743 KSPS(ph)LESLSRPPSLGFGDTR ddPTM_A459_Selumetinib_30min_R1 1 KSPSLESLSRPPSLGFGDTR 20 2 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 KSPS(0.444)LES(0.444)LS(0.11)RPPS(0.002)LGFGDT(0.001)R 79.455 0.005072699999999999 59173000.0 2405.1 2425.0 2450.6 2402.3 2298.3 2218.6 2532.5 2296.2 1254.7 2038.1 True False 2461.134150490061 2141.0798726480853 2117.8219801822474 1982.7834017559885 2090.419170797822 2196.2828983276254 2341.471486072553 2235.2973168912295 2129.1342603377557 2299.709987775158 1.0701932694004916 0.9310216870951895 0.9209082847142491 0.8621884551948316 0.9089925172783142 0.9550260293700804 1.018159462940715 0.9719909591964488 0.9258272876388102 1.0 11.167236221666847 -7.00071667434032 24.93602586530796 0.9780792563999043 0.9329024760434194 0.10490040976682846 0.054242599831364556 57.01991503463743 1984014.7794951382 0.020155166315987304 0.017561625842077492 9.983511571848389e-08 7.00071667434032 -0.04517678035648498 KSPS(ph)SDSWTCADTSTER ddPTM_A459_Selumetinib_30min_R1 1 KSPSSDSWTCADTSTER 17 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 KS(0.032)PS(0.533)S(0.328)DS(0.097)WT(0.007)CADT(0.002)S(0.001)TER 105.5 0.0047555 6777200.0 1798.9 2200.9 2025.5 2620.0 2476.4 2048.5 2227.0 2056.7 872.87 1767.5 True False 1840.8108699499282 1943.2176048293481 1750.4482252750918 2162.466183491106 2252.410057243931 2027.893949889182 2059.015597032013 2002.1496348968697 1481.1966380975657 1994.37584190795 0.9230009867091493 0.9743487481127627 0.8776922526300253 1.0842821789409312 1.1293809370901369 1.0168063146759572 1.0324110199119862 1.0038978575780795 0.7426868130735862 1.0 10.96172159718763 -8.115001760918519 12.888391323095233 0.8714082463657309 1.0083042244743226 0.2642891803327404 0.08926364897127774 0.9947303905649353 106.99818431372702 0.06126975744874138 0.02315055090683121 7.673583779745597e-09 8.115001760918519 0.13689597810859166 KSPSGPVKS(ph)PPLSPVGTTPVK ddPTM_A459_Selumetinib_30min_R1 2 KSPSGPVKSPPLSPVGTTPVK 21 2 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 KSPS(0.005)GPVKS(0.992)PPLS(0.002)PVGTTPVK;KS(0.001)PS(0.005)GPVKS(0.883)PPLS(0.061)PVGT(0.036)T(0.013)PVK 101.86 0.0002604 94401000.0 4619.6 5490.5 6368.700000000001 6927.6 4946.200000000001 4507.700000000001 4679.5 4614.6 2378.7 4124.8 True False 4727.227691823165 4847.669707535801 5503.865520764986 5717.824707157631 4498.817083322537 4462.3566306641305 4326.521547512936 4492.205817666699 4036.480166625821 4654.258258954405 1.0156779939592677 1.0415558049898257 1.1825440735214912 1.2285147039610473 0.9666023742165977 0.9587685904792516 0.9295834710480599 0.9651818974643422 0.8672660480023792 1.0 12.184335550965157 -6.406499391778351 7.026908015191677 0.9434283366824201 1.1159496485629956 0.6181575043547967 0.06530671986632268 0.18393677307560202 10.030316678700554 0.021836877492493818 0.024741283996176786 3.921936955925165e-07 6.406499391778351 0.1725213118805755 KSPSGPVKS(ph)PPLSPVGTTPVK ddPTM_A459_Selumetinib_30min_R2 1 KSPSGPVKSPPLSPVGTTPVK 21 2 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 KS(0.003)PS(0.015)GPVKS(0.981)PPLS(0.001)PVGTTPVK 81.315 0.0020353 12283000.0 105490.0 87623.0 103140.0 104300.0 95240.0 77699.0 79031.0 80809.0 59119.0 91062.0 True False 99627.28810992856 94343.40234764795 96504.0846903414 90094.16007246428 83275.09974359711 88401.33196870371 82706.09809695558 81044.14081134988 70944.4519228751 88432.80345250986 1.1265874677763705 1.0668371765270588 1.0912702178684857 1.0187866555745526 0.9416765780620927 0.9996441197996957 0.9352422954833765 0.916448847569015 0.8022413533567739 1.0 16.432294004818715 -6.114505666385887 0.6767850463141297 0.9033875825284402 1.1270291668566093 0.6739055180860902 0.05165809250073934 0.5279714301598739 0.49118811567691556 0.031274128179448225 0.07052483674331893 7.682354321883158e-07 6.114505666385887 0.22364158432816905 KSPSSDS(ph)WTCADTSTER ddPTM_A459_Selumetinib_30min_R1 1 KSPSSDSWTCADTSTER 17 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 KS(0.259)PS(0.259)S(0.124)DS(0.35)WT(0.004)CADT(0.003)S(0.001)T(0.001)ER 79.332 0.031969 7397300.0 708.32 692.99 665.51 686.39 642.6 464.67 839.5 520.73 320.75 439.36 True False 724.8224778492041 611.8544086376892 575.1373973847575 566.5248716360537 584.4769434602445 459.9958416866033 776.1758391146723 506.9185488305767 544.2893233468835 495.75613572881326 1.4620544772151725 1.2341842380593018 1.16012159191786 1.1427490873173016 1.1789605843223752 0.9278671680187304 1.5656404090160434 1.022515935350661 1.097897300951649 1.0 8.953486817863245 -4.638612696878678 1.7248360552458133 1.145857575913914 1.6635650768498729 0.2683112986880165 0.16241106590467697 1.9658620597050223 4.390298452709884 0.04320682449015391 1.8887289636881202 2.2981972631282947e-05 4.638612696878678 0.5177075009359589 KSPT(ph)MEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R2 4 KSPTMEQAVQTASAHLPAPAAVGR 24 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 KS(0.421)PT(0.579)MEQAVQTASAHLPAPAAVGR;KS(0.425)PT(0.573)MEQAVQT(0.002)ASAHLPAPAAVGR;KS(0.194)PT(0.806)MEQAVQTASAHLPAPAAVGR;KS(0.172)PT(0.822)MEQAVQT(0.005)AS(0.001)AHLPAPAAVGR 72.92699999999998 0.00098849 31757400.0 55323.6 41899.6 64342.4 82460.5 86896.9 61582.7 60131.7 66136.2 60468.2 73822.9 True False 52248.935789917974 45113.16459155154 60202.68003470827 71229.23764770332 75980.13455385738 70065.15793290896 62927.94319870305 66328.64539256271 72563.52962267275 71691.44106207095 0.7288029786523677 0.6292684862129113 0.8397471042963743 0.9935528787325192 1.0598215551013022 0.9773155190484462 0.87776089120903 0.9251961518688808 1.0121644724625738 1.0 16.129513271498105 -5.5071785030270375 3.359538139382468 0.9733089762952781 0.6814922450196061 0.8383853851552493 0.05242028311299216 0.09412972378160867 2.198904473045986 0.01581593223075205 0.03349750995793253 3.110437627212191e-06 5.5071785030270375 -0.291816731275672 KSPVGKS(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R1 1 KSPVGKSPPSTGSTYGSSQK 20 2 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 KS(0.059)PVGKS(0.94)PPS(0.001)TGSTYGSSQK 67.396 0.0056929 30917000.0 6695.6 7725.1 7225.1 8404.6 5921.4 7112.8 7249.9 6599.5 4164.3 6841.0 True False 6851.5944526303465 6820.641700698441 6243.971104633463 6936.894383881435 5385.810415508076 7041.251689905683 6703.034206072026 6424.4598218028395 7066.5129515617455 7719.108986982908 0.8876146799047024 0.8836047932734731 0.8088979071500301 0.8986651692027463 0.6977243648963136 0.9121845153086544 0.8683689033767581 0.832279973328101 0.9154570771676283 1.0 12.914218612175095 -8.550497683475758 2.92990981857752 0.9998101605377324 0.847997495998885 0.39507084302667395 0.05866816533190761 0.26112075452265027 5.704001261265228 0.05479404979195393 0.014639262875107906 2.815155031113826e-09 8.550497683475758 -0.15181266453884745 KSPVGKS(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 1 KSPVGKSPPSTGSTYGSSQK 20 2 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 KS(0.255)PVGKS(0.727)PPS(0.016)T(0.002)GSTYGSSQK 65.374 0.0066278000000000005 35912000.0 438690.0 379060.0 473830.0 454660.0 454400.0 348950.0 347520.0 356410.0 264630.0 405010.0 True False 414309.3660152105 408132.6831299946 443344.29366709583 392734.5236677523 397314.2096124589 397014.695047287 363680.368597816 357447.09409314825 317563.3943799867 393316.3089576456 1.0533744891311525 1.0376703783568366 1.1271952969406043 0.9985208208339106 1.0101645941542785 1.0094030834862726 0.9246511276423551 0.9088031336418344 0.8073995080996847 1.0 18.585330483663213 -7.072076444047485 1.154909019947795 0.8914621767476509 1.0572719356121234 0.5930442260526723 0.05345743197676145 0.3174249729221509 0.8565250155301848 0.03192284865684581 0.021483259085859206 8.470782992065277e-08 7.072076444047485 0.16580975886447247 KSS(ph)ADTEFSDECTTAER ddPTM_A459_Selumetinib_30min_R1 1 KSSADTEFSDECTTAER 17 1 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 KS(0.054)S(0.916)ADT(0.017)EFS(0.013)DECTTAER 130.87 0.0014864 6199000.0 1237.6 1413.7 1553.3 1802.8 1838.3 1747.7 2258.3 2536.1 1476.9 1369.2 True False 1266.433672049603 1248.1833467887009 1342.3703916661573 1487.9748227472394 1672.0260895782258 1730.1197247846344 2087.9546128322395 2468.8343895862085 2506.1914314918545 1544.950157137406 0.8197246145442917 0.8079117251921085 0.8688761805451362 0.9631215711866494 1.0822524479859434 1.1198547194495412 1.3514705333283703 1.598002613987652 1.6221827092050043 1.0 10.593344579613344 -6.817867294720814 1.099149569714973 1.4564529305728646 0.8418129171451607 0.6551033263537174 0.16870395282044998 0.2769311531646663 0.7082585043198099 0.0918715728208548 0.07853642440897787 1.5210122271329638e-07 6.817867294720814 -0.6146400134277039 KSS(ph)ADTEFSDECTTAER ddPTM_A459_Selumetinib_30min_R2 1 KSSADTEFSDECTTAER 17 1 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 KS(0.001)S(0.999)ADTEFSDECTTAER 172.95 8.5133e-07 3989900.0 14290.0 12563.0 13814.0 15326.0 13553.0 11416.0 12728.0 16569.0 17165.0 26713.0 True False 13495.819007402404 13526.541703588138 12925.222279545991 13238.57236117535 11850.350974642719 12988.450375869987 13319.877220053526 16617.21304685438 20598.479630172224 25941.726281290747 0.5202359650651172 0.5214202615861968 0.49824063901513377 0.5103196378539793 0.4568065689286541 0.5006779516148583 0.5134537723366491 0.6405592621967785 0.7940288709710083 1.0 14.66298686586963 -8.358833732589883 1.3062348555608705 0.9969094397327344 0.4979968797348418 0.9850179164965368 0.020033864811354354 0.046408757987274715 0.16468848840857303 0.020053496580748943 0.006242141838038982 4.3768964031528305e-09 8.358833732589883 -0.4989125599978926 KSS(ph)GTGTEPVAK ddPTM_A459_Selumetinib_30min_R2 1 KSSGTGTEPVAK 12 1 Q6ULP2-7;Q6ULP2-8;Q6ULP2-6;Q6ULP2;Q6ULP2-9;B8ZZI9;A0A0U1RR74 Q6ULP2-7 AFTPH Aftiphilin 1 KS(0.323)S(0.666)GT(0.004)GT(0.007)EPVAK 110.25 0.0037462 6955300.0 22757.0 15160.0 16296.0 17940.0 17759.0 15512.0 29119.0 42087.0 17192.0 32055.0 True False 21492.25704348893 16322.723252916998 15247.533101743265 15496.541051773838 15527.955652525645 17648.637196084033 30473.091198203863 42209.4662021221 20630.88038461526 31129.488861107864 0.6904147106103189 0.5243492215932289 0.48980994097827996 0.4978090427669918 0.49881820166747903 0.5669427235001486 0.9789139594988955 1.3559318750927898 0.6627439492072993 1.0 14.925994267837462 -7.271265647061976 4.651202350523956 1.0350856150564383 0.5344545288952386 0.6443448769963113 0.16511440679887524 0.11245585864655334 6.775688511581387 0.06567850937507862 0.04603437969670768 5.354690243243865e-08 7.271265647061976 -0.5006310861611997 KSS(ph)ISSISGR ddPTM_A459_Selumetinib_30min_R2 2 KSSISSISGR 10 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 KS(0.053)S(0.879)IS(0.011)S(0.053)IS(0.004)GR;KS(0.209)S(0.787)IS(0.002)S(0.002)IS(0.001)GR 112.84 0.014348 77703000.0 246645.0 213109.0 223150.0 206536.0 269955.0 217905.0 230444.0 259865.0 240890.0 309242.0 True False 232937.45829816416 229453.77504656266 208792.77194734986 178405.44050552748 236040.83947167944 247919.43580535662 241160.102616123 260621.16412703306 289074.73102896544 300313.37995279185 0.7756479525979864 0.7640477926179378 0.6952496488174164 0.5940642422710974 0.7859817618142229 0.8255357648211633 0.8030281656249632 0.8678306779671346 0.9625769290545994 1.0 18.196109227592025 -7.784256527413666 0.7699509429381313 1.0022452945395854 0.7161795771360535 0.7633901179548465 0.0547333054187179 0.33436676611769495 0.377409266280714 0.05533884467544723 0.025372363552856773 1.6434007187791303e-08 7.784256527413666 -0.2860657174035319 KSS(ph)PEMEDAR ddPTM_A459_Selumetinib_30min_R1 3 KSSPEMEDAR 10 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 KS(0.071)S(0.929)PEMEDAR;KS(0.002)S(0.998)PEMEDAR;KS(0.025)S(0.975)PEMEDAR 198.52 0.00031560000000000003 54171000.0 8602.3 9712.1 10593.2 11183.3 8889.5 8928.4 9214.300000000001 8507.7 4840.38 7181.7 True False 8802.716852837988 8575.002816967206 9154.70162428245 9230.34659154049 8085.446294568697 8838.58840233858 8519.257932524511 8282.04815909569 8213.771332632241 8103.54115068194 1.0862802679908907 1.0581797090332035 1.1297161887691594 1.1390509926347108 0.9977670433484848 1.0907069191096517 1.0513006319228215 1.022028271973263 1.0136027176145117 1.0 12.98433677094612 -7.431297047696325 0.6684317853507521 0.9994033143261389 1.095620430144834 0.4681457401057778 0.035635435251314136 0.6962807825706082 0.6106759831001839 0.03314518087858164 0.020151058084361618 3.704272711602189e-08 7.431297047696325 0.09621711581869508 KSS(ph)PSTGSLDSGNESK ddPTM_A459_Selumetinib_30min_R2 1 KSSPSTGSLDSGNESK 16 1 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 KS(0.062)S(0.677)PS(0.197)T(0.062)GS(0.002)LDSGNESK 260.25 7.9072e-39 3505800.0 27887.0 24691.0 26886.0 28229.0 26649.0 19953.0 23703.0 22823.0 16223.0 24664.0 True False 26337.15218050602 26584.720305921735 25156.18403126347 24384.161502258845 23301.114374917255 22701.344634699883 24805.23646660347 22889.41115144894 19468.05330849309 23951.886235232083 1.0995857245583156 1.1099217842316267 1.0502798729170617 1.0180476503095153 0.9728300371034005 0.9477894313520614 1.0356276838905552 0.9556412771274652 0.8127983373541793 1.0 14.547851653676307 -5.667005089955768 0.5822092201328065 0.9356729881285847 1.1527926759265348 0.5694066119197605 0.053550954675622736 1.222149108319625 0.6232960616641564 0.03453318873143915 0.158792223530661 2.1527565041491466e-06 5.667005089955768 0.2171196877979501 KSS(ph)SYSSSSTTVK ddPTM_A459_Selumetinib_30min_R1 1 KSSSYSSSSTTVK 13 1 P55085 P55085 F2RL1 Proteinase-activated receptor 2;Proteinase-activated receptor 2, alternate cleaved 1;Proteinase-activated receptor 2, alternate cleaved 2 1 KS(0.004)S(0.97)S(0.017)YSS(0.009)SSTTVK 178.68 0.00019288 10171000.0 4571.0 2739.3 4664.8 2616.1 4018.3 3026.4 3528.3 5697.3 1189.8 3023.5 True False 4677.495406382302 2418.5814825339785 4031.3457819122477 2159.2472452790416 3654.8454744884875 2995.9571637513427 3262.157490349372 5546.189096561453 2019.003700446211 3411.5956763839836 1.3710579594062768 0.7089296950620714 1.1816598929991462 0.6329141698196985 1.0713008870858722 0.878168882816388 0.956196982230613 1.625687690646849 0.591806266616621 1.0 11.736230961142422 KSS(ph)TPEEVK ddPTM_A459_Selumetinib_30min_R1 3 KSSTPEEVK 9 1 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;E9PLJ3;E9PS23 P23528 CFL1 Cofilin-1 1 KS(0.001)S(0.721)T(0.278)PEEVK;KS(0.008)S(0.496)T(0.496)PEEVK;KS(0.147)S(0.426)T(0.426)PEEVK 191.79 0.003512 12396500.0 4725.4 8276.8 7946.299999999999 5520.4 3668.2000000000003 4851.4 3174.86 6097.0 11185.599999999999 5602.7 True False 4835.4926259722 7307.748408220072 6867.23610590149 4556.365770742101 3336.4119576733096 4802.599320718759 2935.377754105551 5935.287754152873 18981.146236099456 6321.8611199194775 0.7648843488092617 1.1559489001101548 1.08626810612204 0.7207317092723694 0.5277578697767733 0.7596812441175441 0.46432177145690595 0.9388513353214049 3.0024617554934867 1.0 12.626133626800382 -8.084443534047535 10.104031890558907 1.9975680135369984 0.7890378725412086 0.4907959853720104 0.49069694983229 0.4040649806890992 46.36200103299816 0.3081737582686133 0.11631097269056062 8.232968730962092e-09 8.084443534047535 -1.2085301409957898 KSS(ph)TPLSEAK ddPTM_A459_Selumetinib_30min_R2 1 KSSTPLSEAK 10 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KS(0.056)S(0.857)T(0.087)PLSEAK 194.06 0.00030792 7884300.0 30398.0 31938.0 32065.0 32169.0 27330.0 25845.0 26086.0 27259.0 23155.0 30909.0 True False 28708.600852835447 34387.54190314399 30001.97280973232 27787.526705379736 23896.561066700015 29404.914152449168 27299.05068842838 27338.31917702962 27786.647004756043 30016.576858773464 0.9564248777569814 1.1456183716396344 0.9995134672048097 0.9257393618239248 0.796112134276076 0.9796225029522141 0.9094658200656619 0.9107740468093709 0.9257100546638235 1.0 14.873471838504676 -5.638545412108805 3.7138370728971686 0.9139797676658918 1.0552071554235007 0.3861465969168847 0.06645287195448048 0.1971948173134171 5.135323631203214 0.017716034457429235 0.03254536514787339 2.2985533479040545e-06 5.638545412108805 0.1412273877576089 KSS(ph)TSGSDFDTK ddPTM_A459_Selumetinib_30min_R1 2 KSSTSGSDFDTK 12 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 KS(0.008)S(0.983)T(0.008)SGSDFDTK;KS(0.001)S(0.977)T(0.022)S(0.001)GS(0.001)DFDTK 210.07 1.148e-05 19355300.0 6869.3 11300.5 9261.2 11474.599999999999 8297.5 9814.4 9519.599999999999 8889.4 5174.5 7375.4 True False 7029.341324668988 9977.432206540081 8003.579908130186 9470.776514918723 7546.992590042608 9715.67604676222 8801.52890772607 8653.624235159348 8780.748569472951 8322.104432479717 0.8446591101686611 1.198907354202371 0.9617254833877852 1.1380266363824925 0.9068610771799519 1.1674542329514201 1.0576085627302685 1.0398360541338278 1.0551115575050016 1.0 13.022732677259523 -6.776436556469389 24.99964951055008 1.0660921749636472 1.024955424205483 0.05336683975017664 0.10441256240937727 981.2308637384258 1635659.479196876 0.0342714704008122 0.03033540755946833 1.6732600552811617e-07 6.776436556469389 -0.04113675075816414 KSS(ph)TSGSDFDTK ddPTM_A459_Selumetinib_30min_R2 3 KSSTSGSDFDTK 12 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 KS(0.005)S(0.953)T(0.036)S(0.003)GS(0.003)DFDTK;KS(0.004)S(0.964)T(0.031)S(0.001)GSDFDTK;KS(0.197)S(0.78)T(0.018)S(0.003)GS(0.003)DFDTK 165.78 0.00089264 26749200.0 117447.0 107648.0 106041.0 99476.0 101885.0 83312.0 97408.0 110216.0 79303.0 127400.0 True False 110919.76591759201 115904.25545712485 99218.43750871107 85927.1971943286 89085.29543654331 94787.4717689629 101937.66501029015 110536.7103127589 95165.81591095519 123721.63097504726 0.8965268647320275 0.9368148038761382 0.8019489940988727 0.6945204045334545 0.7200462419907028 0.7661350001769704 0.8239275881422012 0.8934307561387745 0.7691930276133255 1.0 16.916738231600156 -9.702192134765353 9.587972408149934 0.9999979657776992 0.8101310250015703 0.36446252067885776 0.07470060941804098 0.0 0.0 0.08132825099389289 0.019724998187915586 1.9852164500994637e-10 9.702192134765353 -0.18986694077612887 KSSEGGVGVGPGGGDEPPT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 3 KSSEGGVGVGPGGGDEPPTSPR 22 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 KSSEGGVGVGPGGGDEPPT(0.703)S(0.297)PR;KSSEGGVGVGPGGGDEPPT(0.5)S(0.5)PR;KSSEGGVGVGPGGGDEPPT(0.797)S(0.203)PR 93.679 0.00032881 32855200.0 14719.9 19320.0 20097.0 22171.600000000002 20200.1 17720.8 21733.0 20659.0 10309.6 15265.1 True False 15062.845030060558 17058.005418375673 17367.937784919042 18299.74627247765 18373.00452161731 17542.544841199044 20093.662312661327 20111.05621011059 17494.63821660805 17224.524279665653 0.8744999156721526 0.9903324551327921 1.0083261228539528 1.0624239006752334 1.066677036956399 1.0184632420826176 1.1665728461588238 1.1675826794155715 1.0156819388771903 1.0 14.07217651755334 -3.4564442662201427 0.5891557597126662 1.0882871362765587 4.191229271682088e-13 0.5368338070249423 0.055682139242954704 11.500709299958485 0.9010442810693142 0.02663077088825076 12.070875076076705 0.0003495873698862214 3.4564442662201427 -1.0882871362761395 KSSEGGVGVGPGGGDEPPTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 KSSEGGVGVGPGGGDEPPTSPR 22 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 KSSEGGVGVGPGGGDEPPT(0.435)S(0.565)PR 78.413 0.00073871 13549000.0 3230.9 4084.8 4426.5 4835.7 4598.8 3535.7 4525.7 4504.6 2197.2 2834.7 True False 3306.1736837629783 3606.5497170279978 3825.405613024041 3991.2357723312753 4182.839351984083 3500.1340681587426 4184.322805338025 4385.123374997053 3728.487922861336 3198.5613573162486 1.0336439775340192 1.1275537074749353 1.1959769364042294 1.2478221695519136 1.3077252191571813 1.0942838598836597 1.308189006838024 1.370967408509052 1.1656765359004155 1.0 11.643207443100424 -4.981528829425498 1.6437517869740312 1.2314904004635676 1.0049474524833617 0.21290585984967236 0.10419181010393495 0.9001268507754017 3.190842717008939 0.028615348854930837 0.2895314126365591 1.0434488639927385e-05 4.981528829425498 -0.2265429479802059 KSSEGGVGVGPGGGDEPPTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 KSSEGGVGVGPGGGDEPPTSPR 22 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 KSSEGGVGVGPGGGDEPPT(0.284)S(0.716)PR;KSSEGGVGVGPGGGDEPPT(0.452)S(0.548)PR 93.126 0.00014776 27788000.0 203020.0 181362.0 201628.0 201215.0 215126.0 155704.0 163685.0 195141.0 156790.0 207715.0 True False 191736.96115345246 195271.88222925723 188655.4739959677 173809.16988476462 188099.9486291589 177150.812659816 171296.67683567415 195708.82800266834 188152.38107863095 201717.72824161712 0.9505211208991521 0.9680452180948663 0.9352448872019644 0.8616454855002943 0.9324909132619872 0.878211420503532 0.8491899959853568 0.9702113428932169 0.9327508430655256 1.0 17.621978357209308 -10.992020995449913 4.991878685567165 1.000182408229326 0.9185286160480866 0.2592578220936482 0.04061056603257994 8.782471002028781e-05 9.339693348787863e-06 0.04188988283556081 0.010137137270254856 1.0185421466558633e-11 10.992020995449913 -0.08165379218123947 KSSGEIVYCGQVFEKS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 2 KSSGEIVYCGQVFEKSPLR 19 2 M0R0P7;M0R3D6;M0R1A7;M0R117;Q02543 M0R0P7 RPL18A 60S ribosomal protein L18a 1 KSSGEIVY(0.001)CGQVFEKS(0.999)PLR;KSSGEIVYCGQVFEKS(1)PLR 112.41 0.00064822 110509000.0 6318.799999999999 8052.200000000001 7997.400000000001 7927.6 7143.4 6993.9 6659.400000000001 6780.599999999999 3513.58 6369.6 True False 6466.015745755518 7109.444680633781 6911.397006573698 6543.193479482486 6497.280731269705 6923.547715953119 6157.076096486302 6600.756461507131 5962.288638270131 7187.200205158066 0.8996571072439344 0.9891813888155666 0.9616257804553112 0.9103953267903413 0.9040071997169046 0.9633163844502718 0.8566724066024388 0.9184044235709393 0.8295704124105451 1.0 12.811214158694856 -5.770198067170034 21.98184620381962 0.907895745424383 0.9540574259542661 0.10651715813262175 0.04969456522024903 76.39898347571454 191743.24997458654 0.013285377647782978 0.020129840910389305 1.6974693169883804e-06 5.770198067170034 0.04616168052988312 KSSPS(ph)TGSLDSGNESK ddPTM_A459_Selumetinib_30min_R1 2 KSSPSTGSLDSGNESK 16 1 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 KS(0.001)S(0.223)PS(0.758)T(0.009)GS(0.009)LDSGNESK;KS(0.023)S(0.221)PS(0.753)T(0.001)GS(0.003)LDSGNESK 213.71 3.3469e-08 13093000.0 4935.6 5611.4 6443.0 6919.4 5780.200000000001 4943.1 5755.7 5557.5 2930.8999999999996 4817.6 True False 5050.589876994201 4954.414679330916 5568.075988865675 5711.05668322457 5257.381930577198 4893.3769019757 5321.5429150593445 5410.097046695848 4973.523235533534 5435.985887397874 0.92910283095158 0.9114105117190658 1.024299198747742 1.0506018230224599 0.9671441463388031 0.9001820467047031 0.9789471542588365 0.9952375077422398 0.9149257077844045 1.0 12.408325995328184 -6.499804440710905 0.002381066782000256 1.9341506836386886 5.203660701840571e-05 0.019490036519084875 0.04851407145596864 458005.6512459899 356.66708228697155 143703.31848314704 146006.8737771367 3.16370192884079e-07 6.499804440710905 -1.9340986470316701 KSSSGPVWSGASSACTS(ph)PAVGK ddPTM_A459_Selumetinib_30min_R2 2 KSSSGPVWSGASSACTSPAVGK 22 1 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 KSSSGPVWSGASSACT(0.027)S(0.973)PAVGK;KSSSGPVWSGASSACT(0.01)S(0.99)PAVGK 163.09 2.0409e-12 6770000.0 49348.0 57893.0 58503.0 59232.0 61005.0 42192.0 41751.0 40479.0 35507.0 54023.0 True False 46605.43571569587 62333.20694466513 54738.98067325026 51164.499419100735 53341.006508380306 48003.56501915792 43692.504228037 40596.7871883408 42609.39214847219 52463.215621389216 0.8883450082822386 1.1881316500784966 1.0433782989644504 0.9752452039604108 1.0167315494598317 0.9149947148795603 0.8328216963167542 0.7738143136576919 0.8121765249002458 1.0 15.679018616791213 -6.887365694626292 1.9534910397464498 0.8349747825504442 1.035982348869674 0.432474800371898 0.08961778829950319 0.2755053154706415 2.150204056056829 0.03721281160984361 0.031221784485219086 1.2960874500100652e-07 6.887365694626292 0.20100756631922978 KSSTS(ph)DWPTDNQDGWDGKQENEER ddPTM_A459_Selumetinib_30min_R2 1 KSSTSDWPTDNQDGWDGKQENEER 24 2 A0A3F2YNX6;Q92794;A0A3B3IS53;A0A3B3ISZ3;A5PLL3 A0A3F2YNX6 KAT6A;MYST3 Histone acetyltransferase KAT6A;Histone acetyltransferase 1 KS(0.178)S(0.178)T(0.178)S(0.435)DWPT(0.031)DNQDGWDGKQENEER 56.404 0.005428100000000001 9426300.0 17125.0 17601.0 17258.0 16792.0 15659.0 15993.0 11455.0 12799.0 11344.0 18462.0 True False 16173.261056806605 18950.94010386491 16147.63906908967 14504.90063218429 13691.776426763841 18195.890580000763 11987.68019765188 12836.242971011492 13613.116977842916 17928.954089963303 0.9020749886274994 1.0570019873314147 0.9006459042766571 0.8090210148010915 0.763668441452954 1.0148885701139083 0.6686212780455849 0.7159504623974284 0.7592811554726213 1.0 14.130003708623834 -5.583010254968923 3.5963839784709015 0.8067870119600696 0.9807461047035194 0.24626181201820585 0.11159209788369333 0.283513757804517 7.427438334012442 0.030868365327776773 0.05926089497052601 2.612099674321833e-06 5.583010254968923 0.17395909274344978 KSSVNGS(ph)SATSSG ddPTM_A459_Selumetinib_30min_R2 1 KSSVNGSSATSSG 13 1 R4GMX3;P35226 R4GMX3 COMMD3-BMI1;BMI1 Polycomb complex protein BMI-1 1 KS(0.081)S(0.081)VNGS(0.805)S(0.034)ATSSG 99.732 0.020657 8920500.0 9936.8 7246.7 9882.2 11179.0 11164.0 9608.6 19187.0 43605.0 18972.0 33191.0 True False 9384.552436162096 7802.4985881869125 9246.390010925828 9656.400915149365 9761.47851257369 10932.097431813625 20079.233518319237 43731.883330803656 22766.9301219707 32232.689589425416 0.29115015084688706 0.24206787232383734 0.2868637438794215 0.2995840880221594 0.30284405790871827 0.3391618127765584 0.6229462627563861 1.3567556380759112 0.7063304493659087 1.0 14.976236955642582 -7.498700047677018 3.673848972645125 1.025987234540778 0.2960661810509459 0.8214353825301194 0.1513100939682145 0.08353804206073909 2.412606564837098 0.06756694128468795 0.040320039147341086 3.1717573308709263e-08 7.498700047677018 -0.7299210534898319 down KSTGS(ph)PTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R2 1 KSTGSPTQETQAPFIAK 17 1 O15231-3;O15231-2;H0Y704 O15231-3 ZNF185 Zinc finger protein 185 1 KS(0.335)T(0.078)GS(0.574)PT(0.013)QETQAPFIAK 84.37100000000002 0.0063203 6275000.0 23130.0 26636.0 25491.0 27279.0 26687.0 15871.0 14351.0 13775.0 11179.0 23216.0 True False 21844.527196726227 28678.89555176104 23850.936812502285 23563.553141100252 23334.34047519294 18057.08618740651 15018.349935967019 13815.08296942598 13415.112367357715 22545.693757587913 0.9689002002599408 1.2720342900119876 1.0578932309179923 1.0451465097706196 1.0349799268137225 0.8009106475745182 0.6661294213185384 0.6127592753616825 0.5950188320482603 1.0 14.460564283635877 -6.808782272279405 2.1507687150941073 0.6853355905239387 1.0969990336084119 0.6403004611420555 0.12822862510304595 0.1759730994580652 1.6716239108910194 0.04933989001406132 0.044033069191973466 1.553165473509228e-07 6.808782272279405 0.4116634430844732 KSTKRT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KSTKRTK 7 3 Q8TCU6-3;Q8TCU6 Q8TCU6-3 PREX1 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 1 KST(0.005)KRT(0.994)K 82.645 0.036801 0.0 10128.0 10089.0 10149.0 9270.8 7720.0 10733.0 9792.2 8136.2 4580.3 5538.8 True False 10363.962694342583 8907.775189751152 8770.821544466513 7651.828814469224 7021.727363076704 10625.035764784283 9053.566470254547 7920.401545897752 7772.4345681238765 6249.758932480768 1.6582979929801438 1.4252990052874432 1.403385576823367 1.224339834085716 1.1235197131498817 1.7000712954806403 1.4486265099285744 1.2673131286287618 1.2436374989968935 1.0 12.609584827457308 -13.563056775995692 0.1391466127626571 4.4141787570035486e-12 1.5375669779357404 0.38537590744399797 0.16511578830634 125.6318770236573 1.377308338025977 36.46139831901064 1.1742901712701341 2.7349111637283567e-14 13.563056775995692 1.5375669779313261 KSVSS(ph)PTSSNTPTPTK ddPTM_A459_Selumetinib_30min_R1 1 KSVSSPTSSNTPTPTK 16 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 KSVS(0.067)S(0.469)PT(0.067)S(0.067)S(0.279)NT(0.016)PT(0.016)PT(0.016)K 93.909 0.042413 0.0 1513.6 1586.9 2130.5 1819.9 2174.5 1498.8 1767.3 1888.7 937.48 1430.0 True False 1548.8639350470899 1401.1050102702054 1841.1898019988087 1502.088628753994 1977.8168589391576 1483.7234328015177 1633.9911381386062 1838.6055406377786 1590.8350891698735 1613.554429379559 0.9599080804746427 0.8683345195916048 1.141076971730529 0.9309190947661892 1.2257515599890014 0.9195372686448738 1.0126656457240835 1.1394753763247738 0.9859196939402772 1.0 10.656026529156621 -5.247873993667352 24.97269516907835 1.0462280656340353 0.914121295515226 0.2309615142378756 0.09505799139592976 1066.0832294718512 1962558.4500790965 0.02260743930235967 0.05917461099174189 5.651009095783422e-06 5.247873993667352 -0.13210677011880922 KSVSS(ph)PTSSNTPTPTK ddPTM_A459_Selumetinib_30min_R2 2 KSVSSPTSSNTPTPTK 16 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 KS(0.033)VS(0.024)S(0.374)PT(0.374)S(0.158)S(0.037)NTPTPTK;KS(0.333)VS(0.122)S(0.536)PT(0.007)S(0.001)SNTPTPTK 82.406 0.010314 39083000.0 129454.0 138359.0 147798.0 168094.0 140741.0 94362.0 119851.0 105888.0 106249.0 130379.0 True False 122259.46492542147 148970.69040569523 138288.83759029486 145199.30722167625 123059.85733949619 107359.50896705019 125424.30898025105 106196.11654929804 127501.76884510175 126614.61950467573 0.9656030670368723 1.176567848076927 1.092202765614977 1.1467815311510232 0.9719245520060321 0.8479234814040216 0.9905989487700453 0.8387350288990627 1.0070066896215981 1.0 16.950084469007088 -6.4003538224197944 4.89972807193984 0.9282620764803573 1.0999825245620776 0.4999378912631558 0.0749464410103212 0.16792621661481696 6.008383252733085 0.022167664615671365 0.025120804389675098 3.9778296224688036e-07 6.4003538224197944 0.17172044808172027 KSVSSPTSSNTPT(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 KSVSSPTSSNTPTPTK 16 1 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 KSVSSPTSSNT(0.034)PT(0.869)PT(0.097)K 79.804 0.030094 10740000.0 3419.2 3660.4 3886.8 4813.6 3768.0 3252.9 3401.4 2961.0 1855.4 2864.7 True False 3498.860707394961 3231.8386663262067 3358.993908664147 3972.9951224629 3427.1850652944336 3220.1787793968883 3144.8296595171496 2882.4646613164928 3148.4782869456226 3232.412149540992 1.0824302550316194 0.9998225835109342 1.0391601544812687 1.2291115546719722 1.0602562132372568 0.9962154052211936 0.972904912501248 0.8917379739850959 0.9740336755610549 1.0 11.65839544568174 -6.881169507177229 2.681352489209747 0.9527010874875949 1.0843200663853907 0.4805366221467958 0.06096911065167166 0.25296259523241593 3.68668128678102 0.025423457398406384 0.021970416219135563 1.314711593925579e-07 6.881169507177229 0.13161897889779584 KSYES(ph)SEDCSEAAGSPAR ddPTM_A459_Selumetinib_30min_R1 2 KSYESSEDCSEAAGSPAR 18 1 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 KSYES(0.967)S(0.033)EDCSEAAGSPAR;KS(0.002)YES(0.964)S(0.033)EDCSEAAGSPAR 199.36 3.4046e-10 10570000.0 1092.75 1296.99 1536.68 2071.57 1875.0 1274.15 1375.37 1326.07 859.1500000000001 1001.385 True False 1118.2089488786387 1145.1378078457076 1328.0072963790328 1709.8091876849894 1705.4065810581358 1261.3332078356375 1271.6247335832595 1290.898315917582 1457.914800166719 1129.9225190659076 0.9896332978681118 1.013465780638108 1.1753082835068012 1.5132092323449458 1.5093128531219764 1.1163006193365943 1.125408788767654 1.1424662259008265 1.290278559428976 1.0 10.142008132354036 -10.633444272359519 14.47364822371529 0.9999993153923096 1.2124006664718237 0.11590212286672807 0.17233034326842217 0.0 0.0 0.18645207210186676 0.04522126984654569 2.3257108964474577e-11 10.633444272359519 0.21240135107951408 KSYES(ph)SEDCSEAAGSPAR ddPTM_A459_Selumetinib_30min_R2 2 KSYESSEDCSEAAGSPAR 18 1 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 KS(0.274)Y(0.215)ES(0.418)S(0.089)EDCS(0.004)EAAGSPAR;KS(0.074)Y(0.217)ES(0.556)S(0.152)EDCS(0.001)EAAGSPAR 72.167 0.010434 25068000.0 46574.0 51658.0 53309.0 54180.0 58717.0 34955.0 35641.0 35019.0 20966.0 64703.0 True False 43985.60353049405 55620.00249335 49879.15697845066 46800.590534286865 51340.445523359864 39769.73396010296 37298.37712130171 35120.899492292454 25159.785838985772 62834.85627141676 0.700019163575343 0.8851775239701033 0.7938134968113298 0.7448189319019133 0.8170695147545736 0.6329247223597773 0.5935937365749739 0.5589397601322876 0.4004112897196333 1.0 15.939277464455126 -6.828582010390669 5.027412202879076 0.6035917260768199 0.7915332426704076 0.1900798167548503 0.1486075746535087 0.2742448434481607 13.191878642312238 0.050224003184976995 0.04475234836131726 1.4839456313915574e-07 6.828582010390669 0.1879415165935877 KSYESSEDCSEAAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 5 KSYESSEDCSEAAGSPAR 18 1 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 KSYESSEDCSEAAGS(1)PAR;KSYESSEDCSEAAGS(1)PAR;KSYESSEDCSEAAGS(1)PAR;KSYESSEDCSEAAGS(1)PAR;KSYESSEDCSEAAGS(1)PAR 239.56 9.8711e-25 230080100.0 18241.899999999998 20839.94 25401.19 26850.08 22978.579999999998 19418.889999999996 20488.420000000002 18556.79 11085.960000000001 14898.16 True False 18666.900777441537 18399.990136574736 21951.847916749153 22161.217566424017 20900.171496197792 19223.553597541406 18942.961984078425 18064.603648251035 18812.064433517146 16810.483956367385 1.1104320866604789 1.0945544568694756 1.3058427094500364 1.3182974162995413 1.2432819632346954 1.1435455188224972 1.1268540532947187 1.0746034257632793 1.1190673916554088 1.0 14.037073638412696 -7.234900107509478 1.7490851985640998 1.0740480441272313 1.2167345745103615 0.4263403933631912 0.07403131636355782 0.4198762412046761 2.510547851532023 0.044020741772479124 0.027771612683005768 5.82237123289842e-08 7.234900107509478 0.14268653038313017 KSYESSEDCSEAAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 6 KSYESSEDCSEAAGSPAR 18 1 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 KSYESSEDCS(0.001)EAAGS(0.999)PAR;KSYESSEDCSEAAGS(1)PAR;KSYESSEDCSEAAGS(1)PAR;KSYESSEDCSEAAGS(1)PAR;KSYESSEDCS(0.024)EAAGS(0.976)PAR;KSYESSEDCSEAAGS(1)PAR 183.75 3.0012e-10 181505500.0 160695.0 169172.0 181400.0 196799.0 192563.0 134835.0 132442.0 129493.0 103426.0 181275.0 True False 151764.21521305322 182146.94842628497 169728.92149338665 169994.63670278937 168371.51440493806 153407.29733973645 138600.8154288441 129869.80319127967 124114.0899638909 176041.11974098653 0.8620952618135326 1.0346841050220659 0.9641436145322912 0.9656530073934233 0.9564328757546365 0.871428775080778 0.7873206875346553 0.7377242509156963 0.7050289736085689 1.0 17.425552927830594 -6.984991219212419 2.423986913722126 0.785432944238612 0.9630341817761324 0.4031400054434038 0.08381989363565061 0.2488822553737889 2.945710156727631 0.03324360648339024 0.02666753740943471 1.0351630959237804e-07 6.984991219212419 0.17760123753752044 KT(ph)GSYGALAEITASK ddPTM_A459_Selumetinib_30min_R1 1 KTGSYGALAEITASK 15 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 KT(0.897)GS(0.102)YGALAEIT(0.001)ASK 104.82 0.006095000000000001 629510000.0 7805.0 8836.2 12969.0 12214.0 10150.0 9547.7 9282.7 8788.8 6037.8 7330.6 True False 7986.841314113733 7801.653596162068 11207.881033617718 10081.054185175724 9231.934292128051 9451.658806617994 8582.498465455352 8555.692473954206 10245.705616535673 8271.55391609076 0.9655793089345436 0.943190804932724 1.3549909904854618 1.218761829692595 1.1161064034375756 1.1426702772536563 1.0375920356101056 1.034351291274389 1.2386675732844552 1.0 13.013942668042569 -10.036582689895297 15.13285925481994 1.0000003322301263 1.1177469169824419 0.07630931379261374 0.12195855274750075 0.0 0.0 0.12404475246874287 0.03008527157248377 9.192154390432415e-11 10.036582689895297 0.11774658475231559 KT(ph)GT(ph)T(ph)GAPAGVTET(ph)T(ph)RPSVVK ddPTM_A459_Selumetinib_30min_R1 1 KTGTTGAPAGVTETTRPSVVK 21 2 Q7Z5P9;Q7Z5P9-2 Q7Z5P9 MUC19 Mucin-19 5 KT(0.999)GT(1)T(1)GAPAGVT(0.309)ET(0.72)T(0.72)RPS(0.252)VVK 41.51300000000001 0.036139 14669000.0 1196.3 1131.8 961.96 1214.7 1008.7 892.69 1386.5 1154.1 675.92 1092.3 True False 1224.171462405413 999.288329840455 831.3311156680462 1002.5754477429954 917.4632631004489 883.710349097669 1281.9151887224457 1123.489518954869 1146.9868727564324 1232.5073449030006 0.9932366467980411 0.810776774656138 0.6745039849912398 0.8134437915434077 0.7443876638095444 0.7170020955674044 1.040087261162191 0.9115479299989799 0.9306126064885246 1.0 10.267380528769177 -7.259985118954699 24.999349679629496 0.9631909448138704 0.7865075030756478 0.5057238204718875 0.08613807799815554 117.09622760136615 2012959.282975967 0.03519175982099439 0.02575953698615132 5.495597041285253e-08 7.259985118954699 -0.1766834417382226 KT(ph)MT(ph)S(ph)DK ddPTM_A459_Selumetinib_30min_R2 1 KTMTSDK 7 1 A0A087WTD6 A0A087WTD6 DDX52 3 KT(1)MT(1)S(1)DK 68.485 0.044391 10909000.0 44495.0 51445.0 51339.0 28304.0 31434.0 62610.0 38967.0 24380.0 25978.0 43300.0 True False 42022.14602759765 55390.66607825298 48035.90463367679 24448.946372876602 27484.97989647452 71233.95918300799 40779.042711645656 24450.941763673727 31174.325885966435 42049.81649308911 0.9993419598990163 1.3172629680169101 1.1423570574100246 0.5814281348146856 0.6536290093202114 1.6940373377067008 0.9697793263461137 0.5814755878350205 0.7413665144315181 1.0 15.359811884070583 -5.557531712678427 24.900230314644656 0.8956865662284406 1.1761798731054744 0.1289197562988319 0.3138159509989877 355.7084339486653 255596.17626996437 0.09139987338479448 0.15830999388659997 2.769926768566773e-06 5.557531712678427 0.2804933068770339 KT(ph)PADT(ph)GDS(ph)GK ddPTM_A459_Selumetinib_30min_R1 1 KTPADTGDSGK 11 1 M0QYV0 M0QYV0 3 KT(1)PADT(1)GDS(1)GK 113.54 0.027775 11145000.0 0.0 0.0 0.0 0.0 56.091 118.23 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 51.01757895367038 117.04071354425098 0.0 0.0 0.0 0.0 0.0 KT(ph)PELGIVPPPPIPR ddPTM_A459_Selumetinib_30min_R1 1 KTPELGIVPPPPIPR 15 1 Q8TEH3;Q8TEH3-7;Q8TEH3-6 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 KT(1)PELGIVPPPPIPR 114.58 0.003097 28654000.0 3027.6 3670.9 4303.7 4116.5 3649.5 2948.8 3807.1 3343.6 1943.0 2798.1 True False 3098.1371893159157 3241.1093214448874 3719.281178531926 3397.630551275244 3319.403369371557 2919.1377492961788 3519.927381886205 3254.9168664565427 3297.1290888947638 3157.263390802056 0.9812729588356832 1.026556520715724 1.1780078878965805 1.0761314881658088 1.0513545936781383 0.9245784681127331 1.1148665620171838 1.030929784299586 1.0442996610609598 1.0 11.624458905386883 -6.528426101913012 24.98346777980879 1.0258751675906628 1.0698723276550288 0.0892543715502937 0.06377586438439632 391.4522623697808 1762960.69684309 0.021766400475526464 0.021834035571645375 2.961923913519895e-07 6.528426101913012 0.04399716006436605 KT(ph)PELGIVPPPPIPR ddPTM_A459_Selumetinib_30min_R2 1 KTPELGIVPPPPIPR 15 1 Q8TEH3;Q8TEH3-7;Q8TEH3-6 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 KT(1)PELGIVPPPPIPR 85.046 0.026362 26992000.0 41980.0 40871.0 47517.0 46245.0 45920.0 29960.0 40209.0 32460.0 28917.0 36443.0 True False 39646.91965925494 44005.67427902178 44459.807952597854 39946.351222925354 40151.11906999137 34086.71805019841 42078.79817262196 32554.453225957714 34701.208008487636 35390.795899714714 1.1202607528692097 1.2434214365712106 1.2562534077668552 1.1287214714277551 1.134507378239409 0.96315206210079 1.188975752109637 0.9198564880599404 0.9805150499248129 1.0 15.111086586287445 -6.641103719347579 0.827913377734897 0.9881850487574189 1.2141240523370886 0.5364207196694193 0.07774097418266988 0.47560233926909573 0.71959737739919 0.04818862714128887 0.05204986447319822 2.2850530158485312e-07 6.641103719347579 0.22593900357966978 KT(ph)PESFLGPNAALVDLDSLVSRPGPTPPGAK ddPTM_A459_Selumetinib_30min_R1 1 KTPESFLGPNAALVDLDSLVSRPGPTPPGAK 31 2 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 KT(0.803)PES(0.197)FLGPNAALVDLDSLVSRPGPTPPGAK 77.907 2.9654e-05 28191000.0 788.94 1240.6 1061.7 922.61 967.1 919.89 985.74 1054.0 538.51 1021.4 True False 807.3207669899917 1095.349975260707 917.5269715006493 761.4934830346298 879.625975755373 910.6367417932926 911.3848381761728 1026.0444961254925 913.812138785753 1152.5066392785182 0.7004912071442673 0.9504066509728812 0.7961142610640676 0.6607280661839251 0.7632285539856226 0.7901357881663582 0.7907848919175943 0.8902720914196275 0.7928909974504003 1.0 10.170559346315923 -9.200453780793817 0.5877536264913117 1.0077739064812803 0.7805490818875112 0.4091670761661348 0.07680643291153529 2.582222551815189 1.3528185043043306 0.1319420439980096 0.03413462313408869 6.30298421083418e-10 9.200453780793817 -0.22722482459376914 KT(ph)PPAPSPFDLPELK ddPTM_A459_Selumetinib_30min_R1 1 KTPPAPSPFDLPELK 15 1 O95239 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 KT(1)PPAPSPFDLPELK 140.2 0.00048731 10834000.0 5438.1 6746.9 6057.1 5959.0 5535.2 5578.7 6030.4 6609.3 3426.0 5064.1 True False 5564.7971492994075 5956.969811451284 5234.5790892687055 4918.372514283782 5034.542137318935 5522.583343054329 5575.522072897108 6433.999893967953 5813.67177486025 5714.1265635112 0.9738666246622243 1.0424987520386426 0.916076854631686 0.8607391627779337 0.8810694130347234 0.9664790028138311 0.9757435385664747 1.125981341584847 1.0174208971822074 1.0 12.480317275876486 -7.568551493953709 6.656461525534711 1.0542239875869592 0.9399880741216164 0.41746101923377477 0.05670182422845101 0.20116475160766323 21.659800305878356 0.02934027795843715 0.01688729722736374 2.7005268900005748e-08 7.568551493953709 -0.11423591346534279 KT(ph)PPAPSPFDLPELK ddPTM_A459_Selumetinib_30min_R2 2 KTPPAPSPFDLPELK 15 1 O95239 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 KT(0.997)PPAPS(0.003)PFDLPELK;KT(1)PPAPSPFDLPELK 111.45 0.0040591 7703800.0 82135.0 78109.0 85111.0 85492.0 90415.0 67654.0 78099.0 87816.0 65920.0 85696.0 True False 77570.26551245611 84099.70913997982 79635.05092185005 73847.84211807419 79056.25937964443 76972.72439813492 81730.75825023271 88071.5300212785 79105.84195869243 83221.73381505221 0.9320914376146544 1.0105498321733932 0.9569020888080387 0.8873624560885731 0.949947276457074 0.9249113286824235 0.9820843006211218 1.0582755968171034 0.9505430652826011 1.0 16.344672724893442 -7.515958054370185 24.549994208121678 1.0066815891850829 0.9457104346103216 0.33854196199605624 0.03772007030286411 295.0031953930253 1046489.4334033275 0.017291265788186728 0.010486578074199912 3.048189379850215e-08 7.515958054370185 -0.06097115457476132 KT(ph)PQGPPEIYSDTQFPSLQSTAK ddPTM_A459_Selumetinib_30min_R2 1 KTPQGPPEIYSDTQFPSLQSTAK 23 1 Q9UKY7;Q9UKY7-2;D6R9V8;H0Y8K3;D6RFH2;D6RDN0;Q9UKY7-3 Q9UKY7 CDV3 Protein CDV3 homolog 1 KT(0.911)PQGPPEIY(0.04)S(0.049)DTQFPSLQSTAK 104.95 2.7416e-05 5684200.0 19406.0 18120.0 18623.0 21469.0 21157.0 18990.0 16803.0 21354.0 17361.0 18489.0 True False 18327.492208373067 19509.745735016895 17424.816455189284 18544.885163909265 18499.068514020208 21605.700125943506 17584.372794512845 21416.136604654992 20833.68510686978 17955.174529808883 1.0207359543036505 1.086580679158932 0.9704621041839996 1.0328434921710927 1.0302917681645678 1.2033132894405498 0.9793484750214798 1.1927556910739172 1.160316491064013 1.0 14.132112056058899 -6.586868961718701 24.99999107252921 1.1118287453581819 1.028251724858721 0.22236272902157783 0.07358384505629441 90.17359996308618 35228.298364965645 0.023300502300063336 0.023300504694107625 2.588993966162002e-07 6.586868961718701 -0.08357702049946081 KT(ph)SASDVTNIYPGDAGK ddPTM_A459_Selumetinib_30min_R2 1 KTSASDVTNIYPGDAGK 17 1 Q15042-4;Q15042;Q15042-3 Q15042-4 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 1 KT(0.38)S(0.38)AS(0.239)DVTNIYPGDAGK 103.92 0.0037298 11939000.0 149250.0 123200.0 150840.0 143390.0 148610.0 129810.0 170040.0 200070.0 200520.0 322720.0 True False 140955.28249508824 132649.04384956305 141135.11862217428 123860.03463845311 129940.28320974343 147690.1492021446 177947.1969278677 200652.17057662862 240629.60299691992 313402.23507274216 0.44975838306440874 0.4232549388767906 0.4503322019685538 0.39521107630168817 0.41461185871754763 0.47124791298270413 0.5677917290110114 0.6402384798884931 0.7677979799380455 1.0 18.25765594306946 -8.254944018418044 0.7698947358588609 0.9983912244728165 0.41989139972323186 0.9871117475502345 0.02100359941088591 0.06593095190399452 0.0855811320731994 0.021998134674849675 0.00872559635668703 5.559759192575287e-09 8.254944018418044 -0.5784998247495846 down KT(ph)SDANETEDHLESLICK ddPTM_A459_Selumetinib_30min_R1 2 KTSDANETEDHLESLICK 18 1 F2Z2T1;Q09161 F2Z2T1 NCBP1 Nuclear cap-binding protein subunit 1 1 KT(0.42)S(0.42)DANET(0.159)EDHLESLICK;KT(0.674)S(0.207)DANET(0.119)EDHLESLICK 74.33800000000002 0.00908 100677600.0 9246.8 12824.0 11867.3 13081.9 10929.099999999999 13239.1 19162.5 18850.1 8934.7 10997.6 True False 9462.232448859299 11322.560118284138 10255.785842412793 10797.391742676453 9940.564834689321 13105.926674141028 17717.057197182745 18350.134114245862 15161.533335330962 12409.249085695541 0.7625145070032203 0.9124291115516363 0.8264630495841122 0.8701083899688082 0.8010609478496217 1.056141800654849 1.4277300000050486 1.4787465371614252 1.2217929731790176 1.0 13.599128196619628 -7.016124638924944 3.6510733125071426 1.3192756507870702 0.8425089807915568 0.7262200885227821 0.12842131323872807 0.11088579329076308 3.1790861379763062 0.048373871235948 0.039105266578793436 9.635524523532277e-08 7.016124638924944 -0.4767666699955134 KT(ph)SDANETEDHLESLICK ddPTM_A459_Selumetinib_30min_R2 2 KTSDANETEDHLESLICK 18 1 F2Z2T1;Q09161 F2Z2T1 NCBP1 Nuclear cap-binding protein subunit 1 1 KT(0.402)S(0.369)DANET(0.23)EDHLESLICK;KT(0.482)S(0.482)DANET(0.035)EDHLESLICK 64.58800000000001 0.019444 104652000.0 148588.0 120340.0 146006.0 148390.0 130491.0 102625.0 137343.0 184404.0 179825.0 234138.0 True False 140330.0738048923 129569.69104591216 136612.13291931333 128179.0260129723 114097.55397565878 116760.66221300425 143729.7216399914 184940.58511027458 215795.0247303065 227377.82757641765 0.6171669212457835 0.5698431215874208 0.6008155429024865 0.5637270237789285 0.5017971857318085 0.5135094457429586 0.6321184575118098 0.8133624420706514 0.9490592245973571 1.0 17.79473205318267 -7.920372751152907 1.8265301633874635 0.985293344699092 0.5599177352157818 0.9589465777734687 0.034508471567356036 0.07306692443775388 0.4510805892327197 0.03224793254663566 0.011358131436094085 1.2012329842810194e-08 7.920372751152907 -0.4253756094833102 KT(ph)SDFNTFLAQEGCTK ddPTM_A459_Selumetinib_30min_R2 1 KTSDFNTFLAQEGCTK 16 1 Q9UHD1;E9PHZ2;Q9UHD1-2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 KT(0.499)S(0.499)DFNT(0.002)FLAQEGCTK 93.776 0.012154 2977900.0 17884.0 13665.0 15927.0 18189.0 18113.0 16716.0 20975.0 17527.0 17122.0 20445.0 True False 16890.07887532433 14713.061560099653 14902.274160006442 15711.626822224871 15837.483007725486 19018.477267260234 21950.379061174004 17578.00066824896 20546.878428651835 19854.69972751055 0.8506841758942111 0.7410367198710806 0.7505665844625161 0.7913303670090229 0.7976692281969476 0.9578828956505622 1.1055507946443377 0.8853319823262292 1.0348622094839444 1.0 14.277192921982861 -6.7934440523748325 3.816342558163552 1.0010116667769178 0.7797688299212207 0.7720262325496393 0.05761195969813026 0.10218576605791957 3.162639166716967 0.020153567692489584 0.018410717652818726 1.6089996425779436e-07 6.7934440523748325 -0.22124283685569712 KT(ph)SQSEEEEAPR ddPTM_A459_Selumetinib_30min_R2 1 KTSQSEEEEAPR 12 1 Q7RTP6;A0A5F9ZHV5;J3KSK6;Q7RTP6-2;Q7RTP6-4;Q7RTP6-3;Q7RTP6-5 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 KT(0.73)S(0.269)QS(0.001)EEEEAPR 171.36 0.034363 8719600.0 14813.0 12415.0 15461.0 15791.0 15466.0 8789.0 15408.0 20656.0 18230.0 27462.0 True False 13989.752761137293 13367.190579483155 14466.256092664005 13640.238559005604 13523.022812205727 9999.604971401666 16124.502530372778 20716.105540215118 21876.50938875848 26669.100705155033 0.5245678478552195 0.5012238967960149 0.5424350919289803 0.5114622615065906 0.5070670721788447 0.3749509622373124 0.6046136579047067 0.7767830557635105 0.8202942285387912 1.0 14.70288155689095 -7.983138821934856 1.3868358591478167 0.9566373351324566 0.49571914920831983 0.9019570667024284 0.0562756183768035 0.1262035133461976 0.43580451831789324 0.05232389504500915 0.017812254851207094 1.0395878091791253e-08 7.983138821934856 -0.4609181859241368 KT(ph)T(ph)S(ph)YPTPR ddPTM_A459_Selumetinib_30min_R2 1 KTTSYPTPR 9 1 O95832 O95832 CLDN1 Claudin-1 3 KT(1)T(0.748)S(0.626)Y(0.626)PT(0.001)PR 93.839 0.02602 0.0 22771.0 26704.0 23986.0 33133.0 30301.0 20640.0 21088.0 27329.0 24100.0 28088.0 True False 21505.478979535354 28752.110933106564 22442.76687398219 28620.228242386984 26494.31748562303 23482.9726487348 22068.63378507926 27408.522865440496 28920.673410262185 27277.026458611705 0.7884099468160981 1.0540779060625634 0.822771752926783 1.049242969566839 0.9713051943482071 0.8609066198753834 0.8090557018216298 1.0048207749854374 1.0602575560845842 1.0 14.735398760449888 -7.978440331457367 24.72902539041679 1.030932289751219 0.9156960852930907 0.25092269892690955 0.09005786968716292 277.3811582541652 318156.99334904645 0.04821292984842798 0.023157359360423662 1.0508958295187136e-08 7.978440331457367 -0.11523620445812832 KTAESVTSLPSQNNGT(ph)TSPDPFESQPLTVASSKPSSAR ddPTM_A459_Selumetinib_30min_R1 1 KTAESVTSLPSQNNGTTSPDPFESQPLTVASSKPSSAR 38 2 I3L2B2;O95208-3;O95208-2;O95208;I3L356;I3L2H1;O95208-5 I3L2B2 EPN2 Epsin-2 1 KTAESVTSLPS(0.003)QNNGT(0.332)T(0.332)S(0.332)PDPFESQPLTVASSKPSSAR 129.6 1.2799999999999998e-29 22334000.0 1312.8 1340.9 1833.6 1837.3 1774.9 1460.7 1444.1 1525.4 981.53 1188.6 True False 1343.3856857358742 1183.9068046325026 1584.6071912438454 1516.4500453924477 1614.3606083840466 1446.006684209486 1335.1703743484197 1484.9414368024932 1665.5847218851661 1341.1683879444356 1.0016532583166808 0.8827428496484602 1.181512482315901 1.1306932515138242 1.2036971814242683 1.0781693762002045 0.995527769928123 1.1071998491393118 1.241890829560897 1.0 10.38927466821415 -5.260833946609644 24.99987342304046 1.1189771313521166 0.9421980484063504 0.4316089526577802 0.08037557885202107 47.96886152082123 1980637.8701516532 0.021027231899670044 0.04933983296744076 5.484866398308035e-06 5.260833946609644 -0.17677908294576627 KTDDVEAMSS(ph)QPALALDER ddPTM_A459_Selumetinib_30min_R1 1 KTDDVEAMSSQPALALDER 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KTDDVEAMS(0.002)S(0.998)QPALALDER 188.48 1.3522e-15 7926900.0 2817.7 3056.9 3492.3 3952.8 3214.2 3131.1 3267.5 3274.2 1459.8 2647.8 True False 2883.3469277102186 2698.9967268857463 3018.064841830761 3262.5176832456686 2923.4761775130983 3099.6039768113374 3021.0298443206593 3187.357579899514 2477.173980426442 2987.6709217560788 0.9650818323777971 0.9033781823934421 1.0101731150687832 1.0919936528110137 0.9785134487953417 1.037464987940997 1.0111655277432539 1.0668368984982002 0.8291321384787655 1.0 11.544805535300648 -5.277077651390242 23.508635891627588 1.0093505024672522 0.9342300153953103 0.1359964783107963 0.06808058288533456 563.9382934357038 847756.3804591169 0.017151941462625657 0.035945463539005275 5.2835077477413035e-06 5.277077651390242 -0.07512048707194197 KTDDVEAMSS(ph)QPALALDER ddPTM_A459_Selumetinib_30min_R2 1 KTDDVEAMSSQPALALDER 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 KTDDVEAMS(0.083)S(0.917)QPALALDER 106.58 0.00041897 3495300.0 17518.0 19289.0 20985.0 20755.0 19531.0 14354.0 15719.0 16982.0 15161.0 17425.0 True False 16544.41969011025 20768.40427608944 19634.847946740447 17928.133195627983 17077.34117064465 16331.133207361418 16449.964646607605 17031.414808478567 18193.623633733812 16921.89497441288 0.977693084322211 1.2273096073160104 1.1603220547361714 1.059463684341299 1.0091860986294274 0.9650889118538594 0.9721112600852997 1.0064720785840644 1.0751528514533317 1.0 14.046603515212281 -6.007343394687951 3.2998416450523775 1.0020662347029372 1.1315688952388747 0.394019703818417 0.06450994070740183 0.2259347848669753 5.134817132216951 0.019270448132825694 0.028059498478585444 9.832333601386987e-07 6.007343394687951 0.1295026605359375 KTDDVEAMSSQPALALDER ddPTM_A459_Selumetinib_30min_R2 2 KTDDVEAMSSQPALALDER 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 ; 124.73 0.0014142000000000002 0.0 59362.0 59240.0 61194.0 70368.0 60820.0 50682.0 65882.0 58535.0 54971.0 59649.0 False True 56062.89768491404 63783.517513377534 57256.84466298949 60783.75700842929 53179.247862301316 57662.98545461134 68945.64354270643 58705.32715900911 65966.7360180714 57926.77838328571 0.9678235049420687 1.101105901166113 0.988434818248247 1.0493205164326544 0.9180425590118049 0.9954460970204674 1.1902205761644795 1.013440222250441 1.1387951800389706 1.0 15.821942810833988 KTGS(ph)PGSPGAGGVQSTAK ddPTM_A459_Selumetinib_30min_R2 1 KTGSPGSPGAGGVQSTAK 18 1 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 KT(0.13)GS(0.484)PGS(0.386)PGAGGVQSTAK 66.041 0.016531999999999998 2329300.0 12443.0 13793.0 13850.0 17324.0 15963.0 10988.0 10723.0 10578.0 8793.4 16102.0 True False 11751.467873275591 14850.87874851478 12958.906078739816 14964.441314433096 13957.585228969347 12501.497260867154 11221.640747221409 10608.78022871783 10552.325708124463 15637.093421979693 0.7515122891545549 0.9497211756527719 0.8287285705235102 0.9569835589393417 0.892594605168144 0.7994770462453652 0.7176295775945247 0.6784368387673629 0.6748265437419452 1.0 13.932684753103185 -6.945486116813529 3.6211370851763336 0.7419966188754914 0.8815124271276743 0.1829450377433347 0.10298083194762422 0.29711308590864133 8.024390245039642 0.0368965335152006 0.03137165298218477 1.1337410800746312e-07 6.945486116813529 0.1395158082521829 KTGS(ph)YGALAEITASK ddPTM_A459_Selumetinib_30min_R2 5 KTGSYGALAEITASK 15 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 KT(0.077)GS(0.923)YGALAEITASK;KT(0.04)GS(0.96)YGALAEITASK;KT(0.305)GS(0.68)Y(0.015)GALAEITASK;KT(0.003)GS(0.996)Y(0.002)GALAEITASK;KT(0.317)GS(0.682)YGALAEITASK 115.31 0.0012264 222519500.0 491718.0 500654.0 532686.0 552531.0 501757.0 379407.0 375753.5 390777.0 311234.0 461173.0 True False 464390.2820631146 539052.5519436606 498413.5627046655 477275.3246308611 438721.7998955067 431666.8703361692 393226.78229143453 391914.09637338476 373489.49660454504 447857.73721864645 1.0369147241870622 1.2036245154351155 1.1128836710514112 1.0656851159810439 0.9796008049791054 0.9638481920999552 0.8780171684283288 0.8750861351805792 0.8339467325585257 1.0 18.772681004926348 -6.431116890981485 1.1885331567060884 0.8883427636992074 1.1296122884754567 0.7303519192242185 0.05674364207825142 0.21856728516389434 0.6434564500035034 0.024162382977793315 0.02993876599799805 3.705809659610019e-07 6.431116890981485 0.2412695247762493 KTGSPGS(ph)PGAGGVQSTAK ddPTM_A459_Selumetinib_30min_R1 1 KTGSPGSPGAGGVQSTAK 18 1 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 KT(0.136)GS(0.014)PGS(0.849)PGAGGVQSTAK 136.24 0.00018124 17533000.0 4796.6 4358.6 6186.3 6006.5 5345.5 4471.8 4422.4 4453.5 2788.1 3698.5 True False 4908.351447441117 3848.2930857418314 5346.234438913503 4957.577530969214 4862.000468824678 4426.817752069539 4088.8148075053355 4335.378712993249 4731.202065232881 4173.238501440767 1.1761492772930566 0.9221359106155204 1.281075701057529 1.1879449327560987 1.1650425603871246 1.060763182008703 0.9797702206796267 1.0388523712451383 1.1337003776801835 1.0 12.026951657938543 -6.857332818525164 5.281324459827696 1.0388393668389801 1.1435445032761418 0.2412940049955492 0.0924938842791595 0.33879931096515525 14.993870044879596 0.03386748251755773 0.029956437797707958 1.3888878588217688e-07 6.857332818525164 0.10470513643716162 KTGSPGS(ph)PGAGGVQSTAK ddPTM_A459_Selumetinib_30min_R2 2 KTGSPGSPGAGGVQSTAK 18 1 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 KT(0.016)GS(0.055)PGS(0.928)PGAGGVQS(0.001)TAK;KT(0.14)GS(0.094)PGS(0.766)PGAGGVQSTAK 85.913 0.010743 15758000.0 77694.0 76774.0 93875.0 85382.0 92140.0 71946.0 59445.0 58842.0 51860.0 95920.0 True False 73376.07851372445 82662.31893268133 87835.1847033717 73752.82430783453 80564.54945794877 81855.90843923813 62209.31028803285 59013.22047818253 62233.44908946877 93150.54036991026 0.7877150065081812 0.887405683363949 0.9429380050246543 0.7917594896922183 0.8648854761123098 0.8787486161022792 0.6678362792206396 0.6335252618378276 0.6680954167558601 1.0 16.50727651787072 -7.255177511632803 24.846129620879456 0.7118246765778837 0.8612429812527905 0.20630178504978647 0.10532599182983066 544.8930572959525 2162056.979152325 0.03896795936170452 0.02940772110883301 5.556770858179911e-08 7.255177511632803 0.1494183046749068 KTGSYGALAEIT(ph)ASK ddPTM_A459_Selumetinib_30min_R1 1 KTGSYGALAEITASK 15 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 KT(0.004)GS(0.021)YGALAEIT(0.974)ASK 160.87 0.01601 227280000.0 1817.3 1820.5 2500.2 2738.1 2036.9 2468.4 1906.6 1924.8 1163.3 1726.2 True False 1859.6395541497593 1607.3550136725119 2160.6865726155447 2259.9422355026713 1852.6627546439033 2443.5701371278797 1762.7836269875334 1873.748051368452 1974.0351359296324 1947.7745846118842 0.9547509084683499 0.8252264026706125 1.1093103841100205 1.1602688798575684 0.9511689747266453 1.25454462566303 0.9050244524772807 0.9619943016875422 1.0134823359567458 1.0 10.92761100906395 -5.261860018883762 24.999989496264742 1.0464422541176932 0.8899886528736095 0.2609575150942559 0.10394926560255749 47.763736844990234 2838987.832303883 0.026990726349314924 0.062376138561672345 5.471923046387357e-06 5.261860018883762 -0.1564536012440837 KTHSEEFTNS(ph)LK ddPTM_A459_Selumetinib_30min_R1 1 KTHSEEFTNSLK 12 1 Q9H788;Q9H788-2;H0YAT1 Q9H788 SH2D4A SH2 domain-containing protein 4A 1 KTHSEEFT(0.01)NS(0.99)LK 84.41 0.016771 7849200.0 2844.5 2790.4 2704.7 3216.4 2663.6 2508.2 2243.8 2578.2 1674.4 2049.5 True False 2910.7713155664946 2463.698670778233 2337.4165958536373 2654.7161193056468 2422.677850296774 2482.969785263387 2074.5483595062556 2509.817760826134 2841.3345066625793 2312.573288820563 1.258672029828304 1.0653494454373575 1.0107427112270007 1.14794896755881 1.047611274422514 1.0736826362505156 0.8970735628293525 1.0852922036932147 1.2286462532444498 1.0 11.175283372125648 -4.762041030912228 6.921047818703819 1.0600700043111204 1.2630547743757314 0.333415246906133 0.08350301120810706 0.13235645606420143 35.618836933316686 0.020946766948612885 0.1266574946168357 1.7296529387861854e-05 4.762041030912228 0.20298477006461102 KTKNSEEFAAAMS(ph)RY(ph)ELK ddPTM_A459_Selumetinib_30min_R1 1 KTKNSEEFAAAMSRYELK 18 3 P04114;A8MUN2 P04114 APOB Apolipoprotein B-100;Apolipoprotein B-48 2 KTKNS(0.001)EEFAAAMS(1)RY(1)ELK 58.09 0.023171 1906800.0 469.37 338.55 367.16 286.99 483.56 324.88 388.14 293.24 215.48 433.18 True False 480.3054077649661 298.91240861237503 317.3016886655161 236.8725839695087 439.8220833794518 321.61200216743873 358.86228730669336 285.4623226222388 365.65382196348094 488.7828725305152 0.9826559700800076 0.6115443592874945 0.6491669542813341 0.48461719360823247 0.8998312095152091 0.657985416924281 0.7341957083086811 0.5840268525456916 0.7480904968507316 1.0 8.933049922254995 -8.554146119602384 21.156711695008788 1.0000000043296617 0.6931727824991226 0.2912405209305877 0.13908171431440866 1666.7499321207392 1127787.1119312486 0.12911409901044998 0.033337117015351296 2.7916044400328363e-09 8.554146119602384 -0.3068272218305391 KTKPPRPDS(ph)PATTPNISVK ddPTM_A459_Selumetinib_30min_R2 1 KTKPPRPDSPATTPNISVK 19 3 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 KT(0.002)KPPRPDS(0.913)PAT(0.068)T(0.017)PNISVK 61.757 0.024244 16845000.0 261630.0 241150.0 246580.0 283300.0 258920.0 157130.0 158560.0 177250.0 132620.0 218970.0 True False 247089.65198787188 259645.42958053626 230715.31125600473 244714.05128024143 226392.15482583139 178773.231215877 165933.35418067934 177765.76815468265 159147.70571240524 212647.76714761468 1.1619668304174975 1.221011784244586 1.0849646546998446 1.1507953013697396 1.0646345262053738 0.8407011915238083 0.7803202281709952 0.8359634833658148 0.7484099543915217 1.0 17.698106180837236 -6.669751939219497 2.848818828695474 0.8229939898229236 1.1526583916736934 0.8212727381035014 0.06970039105685706 0.09894152052809915 1.6249482087921412 0.024045434521750057 0.023537103592180718 2.1391836017639202e-07 6.669751939219497 0.32966440185076984 KTPESFLGPNAALVDLDSLVSRPGPT(ph)PPGAK ddPTM_A459_Selumetinib_30min_R1 2 KTPESFLGPNAALVDLDSLVSRPGPTPPGAK 31 2 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 KTPESFLGPNAALVDLDS(0.351)LVS(0.081)RPGPT(0.568)PPGAK;KTPESFLGPNAALVDLDS(0.141)LVS(0.141)RPGPT(0.717)PPGAK 87.098 1.4259e-06 14748400.0 9731.6 10945.4 14620.5 14433.7 12185.8 11213.5 11012.3 10760.0 6995.2 9569.699999999999 True False 9958.32734560271 9663.907479621588 12635.116404657865 11913.125249105196 11083.596541577725 11100.702371043384 10181.633344946407 10474.609846594218 11870.3434908063 10798.06421177171 0.922232647472725 0.8949666616249883 1.1701279189360123 1.1032649015105764 1.0264429183051844 1.0280270753476115 0.9429128356031362 0.9700451526464463 1.0993029174493725 1.0 13.398485080605505 -5.2100130900310555 24.99948146386204 1.0389666767212555 0.9085994631526563 0.41014396054779345 0.06412579104757458 377.51006524021994 183514.84664793406 0.017665346037213432 0.04673804762183901 6.165764174068708e-06 5.2100130900310555 -0.13036721356859926 KTPLALAGSPT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KTPLALAGSPTPK 13 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 KTPLALAGS(0.056)PT(0.944)PK 100.58 0.013498 40669000.0 141240.0 145370.0 144670.0 131630.0 138970.0 109800.0 114880.0 124040.0 87675.0 141310.0 True False 133390.4462285176 156519.41156177697 135362.08970478657 113701.76692558483 121511.346192437 124923.95333483933 120222.1476304014 124400.9358640726 105212.44984417982 137230.0131325268 0.9720209390324751 1.1405625343096184 0.9863883753626379 0.8285488307559944 0.8854575134018982 0.9103253033590898 0.8760630775011263 0.9065140563962141 0.7666868744126204 1.0 17.066236517624894 -5.5630778101609915 5.272158772343013 0.8799418602393014 1.0587060456985962 0.5261913030815035 0.06775919560761895 0.12172862058235606 8.183092799500558 0.01724635260795851 0.031235786796637407 2.734778707105431e-06 5.5630778101609915 0.17876418545929473 KTPSKPPAQLSPS(ph)VPK ddPTM_A459_Selumetinib_30min_R2 1 KTPSKPPAQLSPSVPK 16 2 F5H8D7;P18887;M0QYS5 F5H8D7 XRCC1 DNA repair protein XRCC1 1 KTPSKPPAQLS(0.207)PS(0.792)VPK 49.924 0.045297 132440000.0 213640.0 188800.0 223120.0 232430.0 202780.0 160650.0 177230.0 201210.0 147290.0 187640.0 True False 201766.74406868112 203280.35291231697 208764.70211468765 200772.6330358861 177304.96352379918 182778.0792644986 185471.5461745824 201795.4877878915 176752.11562645313 182222.3456527306 1.107255772314539 1.115562156683668 1.145659174602768 1.1018002886347849 0.9730143846446653 1.003049755559766 1.0178309663955483 1.107413512130188 0.969980465311854 1.0 17.475340359952476 -6.122920290165541 5.567499074246346 1.0174404397490424 1.1222662922092888 0.6622428509789051 0.037032439616211915 0.14921574787458872 6.172940498708818 0.011226179779768941 0.014656211800146002 7.534938463065989e-07 6.122920290165541 0.10482585246024634 KTQMAEVLPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 KTQMAEVLPSPR 12 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 KTQMAEVLPS(1)PR 88.706 0.013749 68240000.0 3919.4 5069.0 6536.8 6345.0 5161.9 4639.0 5164.3 4475.1 2326.9 3337.8 True False 4010.714394175188 4475.519123485833 5649.138464072194 5236.964860401171 4695.007056407467 4592.335871874992 4774.752693198215 4356.405810826559 3948.579349948136 3766.239142925237 1.0649123016283206 1.188325794949308 1.4999415198272592 1.3905024778468054 1.2466035422171455 1.2193426114487584 1.2677773534820376 1.156699201910726 1.048414399644648 1.0 11.878908893578275 -8.08814210220751 1.2971739047263589 0.9954143610834435 1.283008899457561 0.4432420578190529 0.10965108219706253 0.43730823485260845 1.3446815598618336 0.11020249613416144 0.0364922825844324 8.16315227334192e-09 8.08814210220751 0.2875945383741175 KTQMAEVLPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 KTQMAEVLPSPR 12 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 KTQMAEVLPS(1)PR;KTQMAEVLPS(1)PR;KTQMAEVLPS(1)PR;KTQMAEVLPS(1)PR 106.42 0.004573 136184000.0 151038.0 149704.0 172390.0 170752.0 183365.0 137937.0 135812.0 162991.0 133174.0 176742.0 True False 142643.91261301943 161185.81542577117 161298.6150840406 147495.2830363702 160329.04939610127 156936.5696825842 142127.52710637276 163465.2768253873 159812.5211924591 171638.99922913528 0.8310693563447787 0.9390978515936854 0.9397550429008826 0.8593343220293798 0.9341061770120471 0.9143409737147 0.8280608005447224 0.9523784079349228 0.931096789833364 1.0 17.389017868777366 -8.522054777102717 1.4600605355917924 0.9976472307304128 0.8984316779053274 0.3522399556600381 0.042662804000178606 0.490379829513197 2.3096137958191547 0.0395930009399607 0.011761109992099556 3.0056971733202505e-09 8.522054777102717 -0.09921555282508543 KTS(ph)ASDVTNIYPGDAGK ddPTM_A459_Selumetinib_30min_R1 2 KTSASDVTNIYPGDAGK 17 1 Q15042-4;Q15042;Q15042-3 Q15042-4 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 1 KT(0.049)S(0.928)AS(0.011)DVT(0.011)NIYPGDAGK;KT(0.072)S(0.789)AS(0.138)DVTNIYPGDAGK 197.41 1.4220999999999995e-07 17897600.0 2434.63 2928.4 2954.1 3635.8 3236.3999999999996 3446.0 4740.3 5679.6 3299.0 2386.0 True False 2491.3521420346824 2585.5415666237745 2552.9494457097762 3000.875782418692 2943.6681914328265 3411.3363687176593 4382.735354562573 5528.958558059156 5598.162050573252 2692.266341608129 0.9253735796981224 0.960358760448416 0.9482529296060891 1.1146281242836569 1.0933792641312492 1.267087255074481 1.6278981343074335 2.053644720290426 2.0793492694446383 1.0 11.394605425186096 -7.141577913939339 1.9444630159948957 1.8046386605361253 1.0021316661494601 0.5509943890236944 0.2866464055153897 0.22766187069507807 1.6929684032062564 0.13337396579761587 0.09269047155502186 7.218086563391208e-08 7.141577913939339 -0.8025069943866652 KTS(ph)DANETEDHLESLICK ddPTM_A459_Selumetinib_30min_R1 2 KTSDANETEDHLESLICK 18 1 F2Z2T1;Q09161 F2Z2T1 NCBP1 Nuclear cap-binding protein subunit 1 1 KT(0.156)S(0.812)DANET(0.032)EDHLESLICK;KT(0.297)S(0.434)DANET(0.269)EDHLESLICK 87.669 0.0046685 80404000.0 8747.2 12711.0 11054.1 12603.7 9828.7 12588.6 17170.9 17892.199999999997 7931.400000000001 10183.5 True False 8950.992740911675 11222.790210816414 9553.013935824938 10402.700395750717 8939.695820397923 12461.97011353428 15875.6851886291 17417.64073394359 13459.006513463675 11490.65142069002 0.7789804435973539 0.9766887707174464 0.8313727034329682 0.9053185946463973 0.7779973034689003 1.0845312121378348 1.3816175086508504 1.5158096870453714 1.1713005660609845 1.0 13.488172968200073 -7.004817093899199 3.8533050658430716 1.3064530589433585 0.8640104757545733 0.6582142699527747 0.1391251191724892 0.12383553755304041 4.111577143152935 0.05174695468145245 0.04230696669919635 9.889695182590111e-08 7.004817093899199 -0.44244258318878515 KTS(ph)PASLDFPESQK ddPTM_A459_Selumetinib_30min_R1 1 KTSPASLDFPESQK 14 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KT(0.045)S(0.95)PAS(0.006)LDFPESQK 142.57 0.00097876 53662000.0 3373.7 3904.1 4070.1 4756.7 3745.6 3451.1 3774.8 3244.4 2018.7 3185.2 True False 3452.3006459225467 3447.0061570331486 3517.402775458976 3926.0316393176136 3406.811141339391 3416.385067348088 3490.063796891086 3158.3479727035565 3425.586459985516 3594.0514464753614 0.9605596072666606 0.9590864817512788 0.9786734630380559 1.0923693491276594 0.947902719834577 0.9505665453672043 0.9710667331470019 0.8787709413010508 0.9531267181344727 1.0 11.811395344885472 -6.474166795035343 24.99991608823034 0.9449386683563075 0.9968811721470004 0.20438286797484684 0.04515364723972409 598.6904043650162 307259.38633564365 0.014390243113651759 0.01631673183215906 3.3560869569254415e-07 6.474166795035343 0.051942503790692984 KTS(ph)PASLDFPESQK ddPTM_A459_Selumetinib_30min_R2 3 KTSPASLDFPESQK 14 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KT(0.009)S(0.99)PAS(0.001)LDFPESQK;KT(0.032)S(0.958)PAS(0.011)LDFPESQK;KT(0.021)S(0.978)PAS(0.001)LDFPESQK 99.238 0.0055744 153824600.0 605362.0 513102.0 580087.0 571094.0 626283.0 452339.0 554282.0 516732.0 411825.0 564781.0 True False 571718.4034960913 552455.2735170338 542764.8339709706 493310.0120078994 547603.7304989428 514644.59132539056 580057.2112889469 518235.6045704129 494201.5073519173 548474.3050527337 1.042379557673395 1.0072582588238428 0.9895902669839488 0.8994222837120319 0.9984127341139395 0.9383203307507896 1.0575832011550232 0.9448676078282036 0.9010476932085298 1.0 19.065064509210565 -5.1473046751875255 2.2832517072544114 0.964441070746904 1.038298486008618 0.23072380012565563 0.04569051184427084 0.5269947707525209 4.900662568318525 0.012475116431715052 0.05626525732765794 7.123531102008105e-06 5.1473046751875255 0.07385741526171397 KTS(ph)QSEEEEAPR ddPTM_A459_Selumetinib_30min_R1 3 KTSQSEEEEAPR 12 1 Q7RTP6;A0A5F9ZHV5;J3KSK6;Q7RTP6-2;Q7RTP6-4;Q7RTP6-3;Q7RTP6-5 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 KT(0.099)S(0.898)QS(0.003)EEEEAPR;KT(0.002)S(0.997)QS(0.001)EEEEAPR;KT(0.029)S(0.968)QS(0.003)EEEEAPR 222.56 3.5856e-08 31803100.0 5727.299999999999 6773.6 6633.299999999999 6943.6 6166.1 6686.4 8634.6 10367.9 6820.700000000001 5001.3 True False 5860.734946614167 5980.543763038794 5732.534294108749 5731.030607514829 5608.377343713373 6619.140886765452 7983.285170243662 10092.90961231452 11574.229735782043 5643.2655717874 1.0385360873168843 1.059766492815359 1.015818628626594 1.0155521718074365 0.9938177235095146 1.172927412783262 1.4146570046525568 1.7884874429394921 2.050980870658568 1.0 12.462314528996307 -7.354186009237002 2.2599070718785494 1.6824845726770772 1.031168313903072 0.5081457403093792 0.2512242718330879 0.22263265178438213 2.2203701991654823 0.1223272411193224 0.07423716710145309 4.4239885142395964e-08 7.354186009237002 -0.6513162587740051 KTS(ph)QSEEEEAPR ddPTM_A459_Selumetinib_30min_R2 3 KTSQSEEEEAPR 12 1 Q7RTP6;A0A5F9ZHV5;J3KSK6;Q7RTP6-2;Q7RTP6-4;Q7RTP6-3;Q7RTP6-5 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 KT(0.086)S(0.889)QS(0.024)EEEEAPR;KT(0.369)S(0.63)QSEEEEAPR;KT(0.009)S(0.991)QSEEEEAPR 132.51 0.0033644 14688600.0 52232.1 44952.0 51910.2 57306.3 49993.5 41919.1 53487.4 66631.0 67383.0 93619.0 True False 49329.24898366295 48399.67385653861 48570.35424755231 49501.08308111855 43712.869582439365 47693.07552129746 55974.67008327239 66824.88517864411 80861.4828383278 90915.97621862609 0.5425806446277457 0.5323560926206378 0.5342334347348913 0.5444706765517543 0.4808051499917112 0.5245840995713414 0.6156747406932069 0.7350180678690617 0.889408948806531 1.0 16.47224621397035 -8.074558894945199 1.23889788651555 0.9957598789217905 0.5238896192739106 0.9864251693710754 0.0195474503586653 0.049895278300064454 0.14042331477266443 0.019942610823038758 0.006709281130789635 8.422501656238898e-09 8.074558894945199 -0.4718702596478799 KTS(ph)SVSSISQVSPER ddPTM_A459_Selumetinib_30min_R2 2 KTSSVSSISQVSPER 15 1 P42356 P42356 PI4KA Phosphatidylinositol 4-kinase alpha 1 KT(0.002)S(0.965)S(0.032)VS(0.001)SISQVSPER;KT(0.028)S(0.874)S(0.088)VS(0.009)SISQVSPER 142.84 0.00068204 14456000.0 43423.0 32133.0 31391.0 48572.0 37440.0 29026.0 46124.0 38595.0 33226.0 26881.0 True False 41009.72349604165 34597.49777612019 29371.337235936597 41956.40980862642 32736.452482153258 33024.068028206224 48268.857392972124 38707.305060253784 39872.12841200713 26104.875684774335 1.5709603060841453 1.3253270459471742 1.1251284086009812 1.607225037777042 1.254035946290554 1.2650536408211095 1.8490360948596636 1.4827615165710142 1.5273824282282462 1.0 14.672031667927433 KTSAVS(ph)SPLLDQQR ddPTM_A459_Selumetinib_30min_R1 3 KTSAVSSPLLDQQR 14 1 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 KT(0.006)S(0.022)AVS(0.486)S(0.486)PLLDQQR;KT(0.015)S(0.008)AVS(0.488)S(0.488)PLLDQQR;KTS(0.006)AVS(0.497)S(0.497)PLLDQQR 205.12 2.846e-05 26786100.0 6481.799999999999 6462.299999999999 9140.2 10197.6 7783.5 7309.3 6730.2 7075.200000000001 3741.0 5227.1 True False 6632.813328612729 5705.690911758234 7899.011043524758 8416.780592659888 7079.483799288538 7235.775078313406 6222.535595484892 6887.542712511465 6348.203768170517 5898.049201265657 1.1245774835498827 0.9673861165033779 1.3392582486137479 1.4270448254066344 1.2003093832736014 1.226808192234254 1.055015884599539 1.1677662354924867 1.0763226198262743 1.0 12.526022142010177 -7.254464389531187 24.111736607712643 1.0887567028998644 1.2177341585280101 0.23920044802545315 0.12071894685589464 607.3455865238695 2099530.390536516 0.05169401227205695 0.03913839905931282 5.565902706380009e-08 7.254464389531187 0.12897745562814578 KTSAVS(ph)SPLLDQQR ddPTM_A459_Selumetinib_30min_R2 1 KTSAVSSPLLDQQR 14 1 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 KTS(0.082)AVS(0.459)S(0.459)PLLDQQR 162.64 0.0004921999999999999 8011800.0 28843.0 29276.0 30108.0 32614.0 31809.0 20242.0 15988.0 17113.0 14177.0 28728.0 True False 27240.02152767723 31521.3750628231 28170.884059111806 28171.9169377119 27812.869043931973 23030.151761419085 16731.473679620987 17162.795996790337 17012.79613847664 27898.54799569202 0.9763956723440775 1.1298571906928812 1.0097616572540564 1.0097986799191876 0.9969289100001448 0.8254964295982468 0.5997256087379383 0.6151859946059037 0.6098093757819828 1.0 14.767902417233792 -6.898174469057906 2.6392021910429064 0.6749911947137307 1.033292772304807 0.6239260666784379 0.11604174909558394 0.15905377145800104 2.2467782676787027 0.043413000323664866 0.037099642800295804 1.2642283671678168e-07 6.898174469057906 0.3583015775910764 KTSAVSS(ph)PLLDQQR ddPTM_A459_Selumetinib_30min_R1 1 KTSAVSSPLLDQQR 14 1 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 KTS(0.001)AVS(0.228)S(0.772)PLLDQQR 188.0 0.00016293 25542000.0 2073.7 2366.2 3663.4 3840.0 2990.7 2492.4 2714.1 2733.5 1239.7 1934.8 True False 2122.013175282207 2089.164203983464 3165.9304016157866 3169.416085727423 2720.1917130509687 2467.328718918135 2509.373251865554 2660.99870034064 2103.68035589441 2183.150426547951 0.9719958595054691 0.9569492686250208 1.4501659451024775 1.4517625753984247 1.245993716224218 1.1301689012880038 1.149427552655377 1.2188801412774262 0.963598444849629 1.0 11.09219582504937 -8.260965674733432 24.801147858692378 0.9817992025767125 1.2036833311593182 0.2291184593714125 0.15744379524716606 60.16253239930377 3150381.0198742202 0.13625025285648662 0.044235340253323215 5.483203007160448e-09 8.260965674733432 0.22188412858260576 KTSAVSS(ph)PLLDQQR ddPTM_A459_Selumetinib_30min_R2 1 KTSAVSSPLLDQQR 14 1 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 KT(0.021)S(0.005)AVS(0.234)S(0.74)PLLDQQR 139.39 0.00029314 40595000.0 155430.0 188740.0 169440.0 187670.0 198180.0 108650.0 82131.0 90700.0 90813.0 185430.0 True False 146791.82283558825 203215.7511052478 158538.41487232348 162109.0222511922 173282.85664832103 123615.55127349975 85950.25423948906 90963.92198380662 108978.13752722558 180076.15409499986 0.8151652481324522 1.1284989516048891 0.8803964948556483 0.9002248135845402 0.9622754190813348 0.6864626351820347 0.47729947738747064 0.5051414077613977 0.6051780596654333 1.0 17.458247624883718 -6.848884421844307 4.185147300351304 0.6030796991936334 0.9433098426549356 0.44293369156223406 0.1552648115982162 0.17266187597744756 5.621819962812919 0.053558046300161324 0.047559117654608005 1.4161706132272008e-07 6.848884421844307 0.3402301434613022 KTSDANET(ph)EDHLESLICK ddPTM_A459_Selumetinib_30min_R2 1 KTSDANETEDHLESLICK 18 1 F2Z2T1;Q09161 F2Z2T1 NCBP1 Nuclear cap-binding protein subunit 1 1 KT(0.312)S(0.312)DANET(0.376)EDHLESLICK 51.606 0.048166 2326100.0 17348.0 12774.0 17859.0 19022.0 15937.0 10750.0 18610.0 22699.0 19447.0 22717.0 True False 16383.867609546325 13753.724725116215 16709.971383408996 16431.170785219725 13934.851581412307 12230.714921216048 19475.401875015425 22765.050331978266 23336.943394579626 22061.10118414562 0.7426586493932913 0.6234378152891314 0.757440494195174 0.7448028386283869 0.631648051704087 0.5544018323983639 0.8827937332979359 1.031909066639817 1.0578322088178853 1.0 14.42921718467892 -7.506859332372462 3.8638981896592877 1.0282073924989155 0.6787163985724693 0.8699442962514616 0.06194302434667291 0.07838792514288673 2.60290454490294 0.031450794614495854 0.018758321327136267 3.112724382726717e-08 7.506859332372462 -0.3494909939264461 KTSFDQDS(ph)DVDIFPSDFPTEPPSLPR ddPTM_A459_Selumetinib_30min_R1 4 KTSFDQDSDVDIFPSDFPTEPPSLPR 26 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KT(0.001)S(0.002)FDQDS(0.996)DVDIFPSDFPTEPPSLPR;KT(0.005)S(0.002)FDQDS(0.993)DVDIFPSDFPTEPPSLPR;KT(0.006)S(0.002)FDQDS(0.992)DVDIFPSDFPTEPPSLPR;KT(0.028)S(0.007)FDQDS(0.965)DVDIFPSDFPTEPPSLPR 176.93 1.1777e-21 243317500.0 31232.6 40708.7 45443.8 48645.8 42348.299999999996 37011.5 39320.5 35182.2 17217.8 29338.500000000004 True False 31960.25881193957 35942.50647903882 39272.78156492532 40150.72422476021 38517.90374219963 36639.197913753254 36354.523027883835 34249.05376810847 29217.349061642966 33104.382256190314 0.9654389127277311 1.0857325837070346 1.1863318052878498 1.2128522415563963 1.1635288477554062 1.1067778770256904 1.0981785658025913 1.0345776430159517 0.8825825183969263 1.0 15.014734588750963 -7.920612879261853 2.5417459367153437 0.9421372264515891 1.1253222550701631 0.501576659412363 0.0695912106784223 0.2457429664131437 3.074084858661672 0.05436133961897798 0.020589998134746792 1.2005689876440381e-08 7.920612879261853 0.183185028618574 KTSFDQDS(ph)DVDIFPSDFPTEPPSLPR ddPTM_A459_Selumetinib_30min_R2 3 KTSFDQDSDVDIFPSDFPTEPPSLPR 26 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 KT(0.008)S(0.003)FDQDS(0.989)DVDIFPSDFPTEPPSLPR;KT(0.006)S(0.006)FDQDS(0.988)DVDIFPSDFPTEPPSLPR;KT(0.012)S(0.012)FDQDS(0.953)DVDIFPS(0.021)DFPT(0.001)EPPSLPR 113.67 5.4928e-09 58137700.0 61582.9 57045.0 63630.0 59231.2 57806.5 49919.9 48564.3 52905.4 40565.4 60338.7 True False 58160.36895388117 61420.16807141491 59536.11507510575 51163.80838048079 50544.33067333313 56795.91309726631 50822.63617833482 53059.345955039564 48679.61349197715 58596.564952229885 0.9925559459209884 1.0481871782328356 1.0160342184502082 0.8731537151058504 0.8625818034647382 0.9692703513178369 0.8673313225744091 0.905502668941354 0.8307588257376963 1.0 15.838528473008617 -5.752773841581951 24.387272146702205 0.8971034252228905 1.0218519933525758 0.54153836883842 0.04950280945210456 95.63231224349435 269132.34530075826 0.012810544036424489 0.021738686287981427 1.766957722617095e-06 5.752773841581951 0.12474856812968527 KTSPAS(ph)LDFPESQK ddPTM_A459_Selumetinib_30min_R1 1 KTSPASLDFPESQK 14 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 KTS(0.106)PAS(0.743)LDFPES(0.15)QK 184.87 0.00014128 61395000.0 3937.7 4452.3 5110.8 4955.7 4531.1 4027.1 4767.6 3632.7 2750.6 3861.6 True False 4029.440748569585 3931.0226461818825 4416.781431614882 4090.280025010258 4121.2628050306785 3986.5910303142446 4407.976093583218 3536.3489953273975 4667.567304124517 4357.2739751693025 0.924761851453929 0.9021747699555986 1.0136570380436698 0.9387245439050754 0.9458351319004553 0.9149277858203408 1.0116362016028486 0.8115966577910658 1.0712127194028827 1.0 12.08921011404811 -8.315550237675687 24.999954191056478 1.0356064428720584 0.937229564619676 0.34568965172509514 0.056262552516290906 397.7251630502992 183750.75013941908 0.050407121673556855 0.013015088430869185 4.8355932460524704e-09 8.315550237675687 -0.0983768782523824 KTSYAQHQQVR ddPTM_A459_Selumetinib_30min_R1 1 KTSYAQHQQVR 11 1 D6RAT0;P61247;D6RG13;D6R9B6;D6RB09;H0Y9Y4;D6RAS7;H0Y8L7;E9PFI5 D6RAT0 RPS3A 40S ribosomal protein S3a 0 80.014 0.030088 2351400.0 3390.9 3124.2 4146.6 3596.7 4257.9 4022.2 3090.3 3555.3 2345.3 2429.3 False True 3469.9013724571714 2758.4172115988245 3583.5144956433983 2968.60386342079 3872.7736967933033 3981.740319865398 2857.1961829851953 3461.001894758032 3979.802806065307 2741.124318385847 1.2658679320682822 1.0063086862193689 1.3073155681438067 1.0829876790006 1.412841318730792 1.4525938474071496 1.0423446188926224 1.2626212797222185 1.4518870156202455 1.0 11.420552044949662 -5.289556191696786 24.853571490438163 1.260398670371643 1.1360881939174632 0.06898843437672375 0.16720253800869853 1526.0521276358304 1348935.777713169 0.0428925798536215 0.08931889365145561 5.1338574819325565e-06 5.289556191696786 -0.12431047645417981 KTTEEQVQAS(ph)TPCPR ddPTM_A459_Selumetinib_30min_R2 1 KTTEEQVQASTPCPR 15 1 Q14137 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 KTTEEQVQAS(0.627)T(0.373)PCPR 78.166 0.017197 4404900.0 26240.0 27534.0 29387.0 32134.0 32146.0 26595.0 23229.0 27492.0 24206.0 28414.0 True False 24781.68584704263 29645.76926423594 27496.272414146355 27757.29376575809 28107.53209111375 30258.219844627052 24309.19452739027 27571.99716845439 29047.876372149636 27593.613991561968 0.8980949669956528 1.0743706595773035 0.9964723150274778 1.0059317990838814 1.0186245302883825 1.0965660334989071 0.8809717543640329 0.999216600510749 1.0527028601991888 1.0 14.752046801309596 -4.739491439128813 24.616162407172705 1.0116360155899273 0.8980944315742985 0.28261235219963465 0.055235258541922086 1994.2279705709366 2236527.504073097 0.013652651767960973 0.6508115294993226 1.8218329849545312e-05 4.739491439128813 -0.11354158401562886 KTTEEQVQAST(ph)PCPR ddPTM_A459_Selumetinib_30min_R2 1 KTTEEQVQASTPCPR 15 1 Q14137 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 KTTEEQVQAS(0.235)T(0.765)PCPR 101.28 0.008794499999999998 4685500.0 23734.0 27617.0 26949.0 25753.0 32783.0 26436.0 21071.0 23977.0 21151.0 25432.0 True False 22414.959294729797 29735.135097348877 25215.13067985268 22245.39697359707 28664.506456261504 30077.319037885336 22050.84325139439 24046.769100393958 25381.791008317658 24697.71207972846 0.9075722974812589 1.2039631444952776 1.02095006203222 0.9007067902397237 1.1606138400078336 1.2178180286817897 0.8928293916541937 0.973643591874699 1.0276980688081905 1.0 14.59208978070711 -7.2927882231091985 24.998990182587086 0.9713464174405334 1.0691412694449154 0.15783024788933941 0.1075233984687574 1352.0653722542263 1078192.8975143307 0.04591814712562254 0.030960898796397626 5.095792988320127e-08 7.2927882231091985 0.09779485200438198 KTVQSQIGPPLTDSRPLGS(ph)PPNATR ddPTM_A459_Selumetinib_30min_R2 1 KTVQSQIGPPLTDSRPLGSPPNATR 25 2 Q96QT6;Q96QT6-4;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7EPF7 Q96QT6 PHF12 PHD finger protein 12 1 KTVQSQIGPPLT(0.056)DS(0.202)RPLGS(0.655)PPNAT(0.087)R 42.057 0.035152 6710200.0 23976.0 29373.0 30137.0 33393.0 31541.0 23085.0 17136.0 19086.0 16906.0 31029.0 True False 22643.50990353257 31625.814650918943 28198.01823068463 28844.815793861944 27578.537599882387 26264.749205234653 17932.857954339837 19141.53710014261 20287.672393107583 30133.112146976015 0.7514494285584419 1.0495369511340942 0.9357818101610995 0.9572464886192196 0.9152236737236585 0.8716241813035044 0.5951213358537703 0.6352326638808048 0.6732684063349739 1.0 14.879062061680084 -7.09175981423981 5.024865128205107 0.696555459314357 0.9286751807865623 0.3488720867862807 0.12411888400781834 0.20725911624078697 8.528424890488212 0.045664598106634556 0.035401544714279524 8.095434919281368e-08 7.09175981423981 0.23211972147220528 KTVSLTPS(ph)PTTQVETPDLVDHDNT(ph)SPLFR ddPTM_A459_Selumetinib_30min_R2 1 KTVSLTPSPTTQVETPDLVDHDNTSPLFR 29 1 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 2 KT(0.065)VS(0.263)LT(0.035)PS(0.449)PT(0.067)T(0.073)QVET(0.046)PDLVDHDNT(0.521)S(0.479)PLFR 54.282 0.038106 2689700.0 4087.1 5672.6 6279.2 5942.3 4723.0 3402.2 3419.9 3228.7 2047.1 6388.4 True False 3859.9553439576202 6107.670179716161 5875.203108276038 5132.948488960736 4129.654515844282 3870.8221679033727 3578.9321264032915 3238.0949824599415 2456.5772007530163 6203.950292943425 0.6221770262002355 0.9844808374211548 0.9470100227847869 0.8273677651478153 0.6656491946012988 0.6239286237199824 0.5768795617969547 0.521940832785694 0.3959698393372376 1.0 12.598971411975597 -6.351380333165291 2.354589031537159 0.5915336762263566 0.8683111120073705 0.2668635172114935 0.17076474781921652 0.34077621327065594 3.702854421878223 0.05628113742035457 0.06748992535360615 4.452661360164395e-07 6.351380333165291 0.276777435781014 KTVSLTPSPTTQVETPDLVDHDNTS(ph)PLFR ddPTM_A459_Selumetinib_30min_R1 2 KTVSLTPSPTTQVETPDLVDHDNTSPLFR 29 1 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 KTVSLTPSPTTQVETPDLVDHDNT(0.431)S(0.569)PLFR;KTVSLTPSPTTQVETPDLVDHDNT(0.129)S(0.871)PLFR 104.29 3.1845999999999995e-09 69436000.0 4320.6 4991.0 7453.5 9112.9 6742.8 5749.5 5250.6 4997.8 2825.52 3570.5 True False 4421.261573575886 4406.65139974705 6441.355639144855 7521.503085319124 6132.914930538027 5691.665250128317 4854.543014717688 4865.242108857676 4794.701072184219 4028.808454615185 1.09741170953688 1.0937852840084836 1.5988239976427736 1.866929929791747 1.5222652056124664 1.4127415870586384 1.2049575127247825 1.207613159986377 1.1901040037512007 1.0 11.9761375003879 -7.296553386285721 2.825780757877784 1.1549944749806922 1.4519300412437979 0.28482672323158187 0.2192645195375264 0.4377395149423969 6.9674518711817095 0.11576020657351946 0.07626035752751073 5.0518054106469024e-08 7.296553386285721 0.2969355662631057 KVAS(ph)DDDISEQDGEVNR ddPTM_A459_Selumetinib_30min_R2 1 KVASDDDISEQDGEVNR 17 1 Q5TF58;H0Y4W3 Q5TF58 IFFO2 Intermediate filament family orphan 2 1 KVAS(1)DDDISEQDGEVNR 101.62 0.0020076 4623400.0 20600.0 16802.0 21096.0 22075.0 21297.0 16166.0 19085.0 22241.0 17822.0 16496.0 True False 19455.13446833379 18090.659373054852 19738.706327588112 19068.346918500964 18621.48046240432 18392.719759663127 19972.49031621006 22305.71762780423 21386.897988286015 16019.717618244764 1.2144492763203547 1.1292745480389432 1.2321507031502112 1.1903048089177386 1.1624100315723682 1.1481300855587968 1.2467442181042883 1.392391436563175 1.3350358912649372 1.0 13.967561096937242 -7.466248459025096 6.550152407598099 1.2817302465709164 1.180302666760731 0.0484077443110289 0.101196695529588 0.3902307486181409 36.40922166791817 0.04098486880483576 0.0270798465088702 3.417838526960046e-08 7.466248459025096 -0.10142757981018535 KVASGVLS(ph)PPPAAPPPSSSSVPEAGGPPIKK ddPTM_A459_Selumetinib_30min_R1 2 KVASGVLSPPPAAPPPSSSSVPEAGGPPIKK 31 2 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVAS(0.005)GVLS(0.995)PPPAAPPPSSSSVPEAGGPPIKK;KVAS(0.003)GVLS(0.997)PPPAAPPPSSSSVPEAGGPPIKK 123.76 3.9687e-17 305110000.0 9141.0 10902.7 14433.599999999999 15128.9 11691.7 10394.9 10459.8 10382.7 6115.5 8522.099999999999 True False 9353.967514710259 9626.206815472278 12473.596398089641 12486.921619625431 10634.187799337293 10290.336743814049 9670.808864766705 10107.317068237344 10377.556841552196 9615.994547283588 0.9727509171012011 1.0010620085253246 1.2971717420132372 1.2985574771517365 1.1058853815949108 1.0701271400700778 1.0057003274298446 1.0510943011186034 1.0791974548783143 1.0 13.23122036263619 -6.736853510432794 3.364449988697653 1.03980870728465 1.1483932816247522 0.18147935407198124 0.10136257570827924 0.4570419645062669 10.76564969706471 0.04070049617394153 0.03850981744333264 1.8329325748732726e-07 6.736853510432794 0.10858457434010216 KVASGVLS(ph)PPPAAPPPSSSSVPEAGGPPIKK ddPTM_A459_Selumetinib_30min_R2 2 KVASGVLSPPPAAPPPSSSSVPEAGGPPIKK 31 2 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVAS(0.012)GVLS(0.988)PPPAAPPPSSSSVPEAGGPPIKK;KVAS(0.174)GVLS(0.825)PPPAAPPPSSSSVPEAGGPPIKK 76.267 1.1141e-05 61842000.0 152748.0 156535.0 168465.0 178226.0 178913.0 129777.0 123664.0 134051.0 102728.0 163022.0 True False 144258.87765869155 168540.73116064374 157626.14531082346 153951.31134300143 156436.34943748612 147652.6037516888 129414.62103556734 134441.0662166623 123276.47046014175 158315.13127797615 0.9112134544195649 1.0645901614085964 0.995648009374777 0.9724358632068305 0.9881326451532217 0.9326499783045649 0.8174494755547774 0.8491990950669472 0.7786777515516689 1.0 17.272439624898965 -7.02484805348257 3.2131433241361056 0.8491781760687778 0.990116830452519 0.45145604259231575 0.0641193543009299 0.20009316039601058 4.226095600187379 0.024175728147136373 0.019311597795090826 9.443912324500996e-08 7.02484805348257 0.1409386543837412 KVDCPGPGSGAEGSGPGSVVPGSSGVGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 KVDCPGPGSGAEGSGPGSVVPGSSGVGTPR 30 1 A0A0G2JRY5;O00268 A0A0G2JRY5 TAF4 Transcription initiation factor TFIID subunit 4 1 KVDCPGPGSGAEGS(0.002)GPGS(0.01)VVPGS(0.076)S(0.061)GVGT(0.851)PR 55.169 0.0067486 3683600.0 6658.6 7940.1 8268.4 8768.9 7896.5 7211.5 7596.4 7074.5 7590.6 6415.9 True False 6288.541668487736 8549.080138554506 7736.420145953233 7574.5606928037605 6904.471074394318 8204.818665520885 7949.647651981039 7095.085623753481 9108.932099084484 6230.6562964898485 1.009290413279657 1.3720994597905813 1.2416701833339265 1.2156922693795555 1.1081450726601747 1.3168466169676565 1.2758925021204612 1.1387380857054534 1.461953872213456 1.0 12.605168419953543 -6.786873846323767 24.999307504712398 1.2496826773294953 1.203897312932024 0.021430041897988805 0.1420582248960523 1156.646609872877 1136849.411551335 0.04753297802903886 0.04193612919357301 1.6335263850328168e-07 6.786873846323767 -0.04578536439747127 KVDEGAGDSAAVASGGAQTLALAGS(ph)PAPSGHPK ddPTM_A459_Selumetinib_30min_R1 1 KVDEGAGDSAAVASGGAQTLALAGSPAPSGHPK 33 1 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 KVDEGAGDSAAVASGGAQT(0.387)LALAGS(0.612)PAPS(0.001)GHPK 117.66 1.0324e-18 20278000.0 12341.0 13687.0 15039.0 16768.0 14851.0 13068.0 14296.0 12288.0 5912.1 10510.0 True False 12628.52128859417 12084.51967708632 12996.786403313803 13839.783574343084 13507.729672157013 12936.547784794651 13217.64121022437 11962.082322950717 10032.401897300431 11859.060876069343 1.0648837560213167 1.0190115223602516 1.0959372364417406 1.1670218846983647 1.1390218680312667 1.0908576926946714 1.114560532942076 1.008687150522118 0.845969339574353 1.0 13.53370214634041 -7.975176388560717 4.148538054805588 0.9218524782234954 1.0987281164194533 0.6559799470414581 0.05125787716572524 0.12473380558519154 4.855173468607623 0.03423822704838038 0.014220635841818192 1.0588235969799768e-08 7.975176388560717 0.17687563819595797 KVDEGAGDSAAVASGGAQTLALAGS(ph)PAPSGHPK ddPTM_A459_Selumetinib_30min_R2 3 KVDEGAGDSAAVASGGAQTLALAGSPAPSGHPK 33 1 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 KVDEGAGDSAAVASGGAQT(0.021)LALAGS(0.974)PAPS(0.004)GHPK;KVDEGAGDSAAVASGGAQT(0.008)LALAGS(0.978)PAPS(0.014)GHPK;KVDEGAGDSAAVASGGAQT(0.019)LALAGS(0.976)PAPS(0.005)GHPK 127.64 4.4245e-25 65636300.0 254272.0 220720.0 334308.0 379479.0 393125.0 285437.0 273083.0 275384.0 280916.0 338726.0 True False 240140.58017146427 237648.51427334003 312798.9872470285 327793.30556221236 343737.12291790877 324753.35581089737 285781.9006036985 276185.32184772455 337107.04944884765 328946.10026415985 0.7300301781313705 0.7224542685944494 0.9509125871862764 0.9964954905955057 1.0449648822158737 0.9872540077237715 0.8687803271545145 0.8396066152659485 1.0248093811665016 1.0 18.327491683771065 -5.268520022981567 6.978606545505106 0.9601467249688677 0.7252964438405389 0.7041990540162886 0.061631123708091394 0.07442915278068862 24.21179993266174 0.017717824225992235 0.04081556447894397 5.388650006350837e-06 5.268520022981567 -0.23485028112832873 KVDLTLLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 KVDLTLLSPK 10 1 E7EVA0;P27816-4;B5MEG9 E7EVA0 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 KVDLT(0.002)LLS(0.998)PK;KVDLTLLS(1)PK 94.532 0.012184 98362000.0 17534.1 26142.0 30141.0 31392.0 20518.4 25398.0 21201.7 20472.6 13624.900000000001 18628.7 True False 17942.610414580588 23081.282486913915 26048.017752661854 25909.9765008217 18662.514342817743 25142.519179538922 19602.438699413393 19929.600143623127 23120.460176676414 21019.875103904174 0.8536021420625842 1.0980694401284459 1.2392089688403414 1.2326417912925303 0.8878508673608351 1.1961307598287785 0.9325668493516638 0.9481312350862379 1.0999332804019413 1.0 14.359466476655754 -7.279782780689659 24.91459201400067 0.9908354509282883 1.09001287265699 0.10138017639676544 0.12957357966146907 1893.6276124146777 2571975.196389467 0.05538406789734963 0.03741325059310541 5.250700167249754e-08 7.279782780689659 0.0991774217287017 KVDTT(ph)PNQGK ddPTM_A459_Selumetinib_30min_R2 1 KVDTTPNQGK 10 1 Q9P2E9;A2A2S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 KVDT(0.324)T(0.676)PNQGK 88.09200000000001 0.040854 32412000.0 153970.0 99706.0 115700.0 124190.0 102930.0 137610.0 302370.0 651170.0 215660.0 313470.0 True False 145412.96379074515 107353.12959467935 108255.98796463534 107275.10776030045 89999.01319412499 156564.5284007944 316430.80413478875 653064.7968930029 258798.02604386472 304419.3066071277 0.47767326393135023 0.3526488867975293 0.35561472487139756 0.3523925895368579 0.2956416076141793 0.5143055154607877 1.0394570819490192 2.1452804822784257 0.8501367042986531 1.0 18.21570033348553 -7.336754153102104 3.301573576555017 1.4011748245960352 0.37361882737747815 0.6298859278083699 0.3281494842744243 0.14199715903078836 3.021161169478852 0.13956869325744248 0.09090177072185297 4.605171909470614e-08 7.336754153102104 -1.027555997218557 KVEEAEPEEFVVEK ddPTM_A459_Selumetinib_30min_R1 1 KVEEAEPEEFVVEK 14 1 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 0 182.7 0.00010317 7178600.0 2967.6 3782.5 3315.6 3507.0 3466.2 3353.8 2964.6 3144.0 2440.4 2764.7 False True 3036.7393060555924 3339.6431415634565 2865.3597312871366 2894.5682845432475 3152.6828220073153 3320.063817006756 2740.9778351868476 3060.610906848718 4141.18056023612 3119.576175458505 0.9734461142335344 1.0705438667714555 0.9185093006635734 0.9278722883302611 1.010612546284094 1.0642675896570417 0.8786378921437903 0.9810983078170481 1.3274817883321803 1.0 11.60713432301307 -8.154421112234584 12.055512357360636 1.1636147108049366 0.9780112077794954 0.3888813415540625 0.09308077357217445 0.5721611328170941 60.88779150801823 0.0591512400330468 0.022344576011833685 7.007754642196804e-09 8.154421112234584 -0.18560350302544126 KVEEAEPEEFVVEK ddPTM_A459_Selumetinib_30min_R2 2 KVEEAEPEEFVVEK 14 1 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 0 ; 193.47 0.0001124 15797600.0 146978.0 150114.0 159328.0 174467.0 159257.0 113014.0 120157.0 125850.0 105402.0 138508.0 False True 138809.5511595516 161627.26110741295 149077.00994320968 150704.29362763814 139249.71188435596 128580.65266105224 125744.53858657856 126216.20266441103 126485.34517794396 134508.91415299746 1.0319728772894736 1.2016100354774233 1.1083058017526013 1.1204037633983068 1.0352452308548568 0.9559266273965895 0.9348416748316781 0.9383482385475667 0.9403491655138404 1.0 17.037342260439324 -6.522633510820319 2.190867902851166 0.947054836542879 1.1228482271260645 0.7634168160005894 0.04227929477016276 0.1344428357890081 1.2968898479568172 0.01456866914491151 0.015698860643084483 3.0016944980095714e-07 6.522633510820319 0.17579339058318544 KVEEDLKADEPSSEES(ph)DLEIDK ddPTM_A459_Selumetinib_30min_R2 1 KVEEDLKADEPSSEESDLEIDK 22 2 Q3KNR6;P50502;F6VDH7 Q3KNR6 ST13 Hsc70-interacting protein 1 KVEEDLKADEPS(0.018)S(0.021)EES(0.961)DLEIDK 54.14100000000001 0.011004 3905000.0 24801.0 16901.0 18949.0 29955.0 23042.0 21228.0 42024.0 33220.0 19248.0 16929.0 True False 23422.659706269213 18197.25235471966 17729.84197011125 25875.07732474276 20147.257961906405 24151.964311402244 43978.199268976234 33316.66470013295 23098.137834055033 16440.21578317565 1.4247172917425548 1.106874301086857 1.078443385655276 1.573889154862701 1.2254862240022675 1.469078303468409 2.675037837032651 2.0265345138734783 1.4049777775844567 1.0 14.00494161453464 -7.01450924895164 24.762939036554283 1.892164372245421 1.2841000388991437 0.21034904337705995 0.42955143882495384 739.887710009928 1262765.2709294336 0.15739961303109115 0.1267217778912351 9.671431296688043e-08 7.01450924895164 -0.6080643333462772 KVEEEGS(ph)PGDPDHEASTQGR ddPTM_A459_Selumetinib_30min_R1 4 KVEEEGSPGDPDHEASTQGR 20 1 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 KVEEEGS(0.692)PGDPDHEAS(0.154)T(0.154)QGR;KVEEEGS(0.99)PGDPDHEAS(0.005)T(0.005)QGR;KVEEEGS(1)PGDPDHEASTQGR;KVEEEGS(0.891)PGDPDHEAS(0.068)T(0.042)QGR 143.47 2.1126e-05 158995200.0 10756.800000000001 12429.6 14339.099999999999 13520.1 11364.6 10523.06 12732.300000000001 11121.900000000001 5680.95 8988.470000000001 True False 11007.412510910775 10974.336653635723 12391.928979038299 11159.06833870921 10336.6739365831 10417.20757057401 11771.892360166463 10826.911082977345 9640.157229828466 10142.227679612077 1.0853052069653193 1.0820440045628588 1.221815302366814 1.1002581179617166 1.0191719475359342 1.0271123760625782 1.1606811375207382 1.06750818705654 0.9504970243575903 1.0 13.30808694602782 -8.132903698186732 4.707169571805073 0.9771159440892254 1.0986126054227456 0.42447123617991356 0.056849696761431666 0.23116506946386203 7.596121251646689 0.04414842162945826 0.01569157956076496 7.36370364454243e-09 8.132903698186732 0.12149666133352022 KVEEEGS(ph)PGDPDHEASTQGR ddPTM_A459_Selumetinib_30min_R2 4 KVEEEGSPGDPDHEASTQGR 20 1 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 KVEEEGS(0.999)PGDPDHEAS(0.001)TQGR;KVEEEGS(1)PGDPDHEASTQGR;KVEEEGS(0.978)PGDPDHEAS(0.002)T(0.02)QGR;KVEEEGS(0.996)PGDPDHEAS(0.003)T(0.001)QGR 146.0 1.2933e-05 104356200.0 158102.2 138583.4 161391.8 171288.5 160947.1 129066.2 134561.1 127110.5 111487.6 156330.8 True False 149315.5126572526 149212.30116413604 151008.02729810518 147958.71081085654 140727.4864126703 146843.8975036888 140818.45777776116 127480.37051072379 133788.2352238149 151817.12360780168 0.9835222082259203 0.9828423673050555 0.994670585962446 0.974585127782339 0.9269539763921498 0.9672419949349025 0.9275531931532701 0.8396969161400496 0.8812460152350015 1.0 17.211974997408916 -6.856954012034815 1.1002847777615121 0.8990949647135487 0.9842718457755328 0.3273890198068766 0.04139932626332999 0.49832155954705604 1.271116658979571 0.02330431749998403 0.019174507519612242 1.3900998227627214e-07 6.856954012034815 0.08517688106198418 KVEEEQEADEEDVS(ph)EEEAESK ddPTM_A459_Selumetinib_30min_R2 8 KVEEEQEADEEDVSEEEAESK 21 1 Q9H3N1 Q9H3N1 TMX1 Thioredoxin-related transmembrane protein 1 1 KVEEEQEADEEDVS(0.989)EEEAES(0.011)K;KVEEEQEADEEDVS(0.98)EEEAES(0.02)K;KVEEEQEADEEDVS(0.978)EEEAES(0.022)K;KVEEEQEADEEDVS(0.991)EEEAES(0.009)K;KVEEEQEADEEDVS(0.978)EEEAES(0.022)K;KVEEEQEADEEDVS(0.989)EEEAES(0.011)K;KVEEEQEADEEDVS(1)EEEAESK;KVEEEQEADEEDVS(0.997)EEEAES(0.003)K 142.23 6.8106e-06 413604400.0 1101756.0 302444.0 734813.0 713184.0 328144.0 396763.0 1319214.0 782276.0 693193.0 501503.0 True False 1040524.8121987163 325640.482289263 687535.931583903 616047.108888979 286919.61707541934 451413.5017940878 1380560.064972949 784552.2936472372 831850.9694306984 487023.30532872194 2.1364990151680776 0.6686342906515905 1.4117105363568645 1.2649232637299994 0.5891291318836573 0.9268827525397396 2.83468994166742 1.6109132459640607 1.7080311359417002 1.0 18.893631285096994 KVEEEQEADEEDVS(ph)EEEAESKEGTNK ddPTM_A459_Selumetinib_30min_R1 1 KVEEEQEADEEDVSEEEAESKEGTNK 26 2 Q9H3N1 Q9H3N1 TMX1 Thioredoxin-related transmembrane protein 1 1 KVEEEQEADEEDVS(0.869)EEEAES(0.054)KEGT(0.077)NK 50.432 0.012529 7226500.0 652.45 884.92 1368.7 1035.2 1167.1 1314.8 891.14 1151.7 642.54 746.53 True False 667.6508155532994 781.313155011853 1182.8380577309401 854.4217531106852 1061.5360110682411 1301.5743057428836 823.9205923390703 1121.1531747511674 1090.3434507351735 842.3543973179875 0.7926008550309285 0.9275349633117764 1.4042047640482853 1.0143257467772704 1.260201186636072 1.5451623567076143 0.9781163308013712 1.3309756301158522 1.2943999036590421 1.0 9.718283524827788 -5.09276793985277 4.9789310057528064 1.235234219648889 0.8208438418944375 0.41947987778414786 0.1760628580284918 0.18058207805393922 7.121775430321631 0.04339198755424845 0.12672120673020057 8.0766648205102e-06 5.09276793985277 -0.41439037775445153 KVEGNFNPFAS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 2 KVEGNFNPFASPQK 14 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 KVEGNFNPFAS(1)PQK;KVEGNFNPFAS(1)PQK 133.35 0.00037645 191258000.0 19520.1 21005.9 24590.0 25468.0 19978.1 20565.9 19055.8 18461.4 12126.2 17668.4 True False 19974.880350497282 18546.519462622036 21250.813063201454 21020.49189356929 18171.08438242002 20359.02571834316 17618.40566408741 17971.74370092142 20577.275737393567 19936.311244790064 1.0019346159494424 0.9302884186997622 1.0659350570058395 1.0543822091994353 0.9114566962415703 1.0212032440887762 0.8837344806548209 0.901457821371943 1.0321506062346917 1.0 14.28311087648959 -6.262652313922509 24.998661358129176 0.952820205488505 1.0109888831510225 0.17164798385967206 0.05814977867093381 194.93594621125536 4017651.997428462 0.017966227447288173 0.02150602987884508 5.461949571029694e-07 6.262652313922509 0.05816867766251754 KVEGNFNPFAS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 KVEGNFNPFASPQK 14 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 KVEGNFNPFAS(1)PQK;KVEGNFNPFAS(1)PQK 70.11399999999999 0.030062 73334000.0 579660.0 563120.0 622390.0 619830.0 640310.0 532760.0 534930.0 531270.0 444150.0 597190.0 True False 547444.8177628332 606309.4932838148 582346.1050069958 535408.0847336117 559868.5333559705 606142.8540862388 559805.3049436858 532815.9077435168 532992.4105878824 579947.5730140394 0.9439557008881225 1.0454556954739376 1.0041357738260563 0.9232008368464204 0.965377836562508 1.0451683605400055 0.9652688122037092 0.9187311621538907 0.9190355049127512 1.0 19.145562961623078 -7.5243425983427645 24.66129652452094 0.9397299804016397 0.988770412966452 0.1616636068497459 0.042410696016226906 68.19982862432454 1148855.6302055256 0.020088173574489346 0.011714189529673423 2.989905084033214e-08 7.5243425983427645 0.049040432564812275 KVELS(ph)ESEEDKGGK ddPTM_A459_Selumetinib_30min_R1 1 KVELSESEEDKGGK 14 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KVELS(0.996)ES(0.004)EEDKGGK 115.2 0.0032014 149460000.0 6670.4 7703.1 9962.1 9182.3 5643.0 7575.6 7006.5 7670.4 4595.2 7125.9 True False 6825.807341661016 6801.217470925967 8609.301537898295 7578.783678118468 5132.591646352569 7499.396342094455 6477.994064034489 7466.956075029395 7797.718779870933 8040.578677143909 0.8489199118297303 0.8458616903108055 1.0707315833338007 0.9425669447973768 0.6383361014727008 0.9326936086593102 0.8056626673461686 0.928659039958767 0.9697957190614491 1.0 12.973083619972137 -8.100217555461686 3.156048734483244 0.9860083937133495 0.8722033757279452 0.1630956835484333 0.10454745961705898 0.5346891256680706 9.62367728906173 0.08700216717704827 0.02893966905058905 7.939304236158462e-09 8.100217555461686 -0.11380501798540432 KVELS(ph)ESEEDKGGK ddPTM_A459_Selumetinib_30min_R2 2 KVELSESEEDKGGK 14 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 KVELS(0.994)ES(0.006)EEDKGGK;KVELS(0.997)ES(0.003)EEDKGGK 100.04 0.010478 100927000.0 207621.0 188630.0 183110.0 174533.0 147571.0 105057.0 166340.0 147499.0 94551.0 148200.0 True False 196082.25599271493 203097.31445895336 171328.90195509346 150761.3043137813 129031.81167852125 119527.64813750642 174075.1395964568 147928.19767022596 113463.84197567233 143921.08093015722 1.3624290112709114 1.411171408290864 1.1904364589801606 1.047527598732694 0.8965455987725557 0.8305082713734718 1.2095180113393738 1.0278424586180903 0.7883754154871493 1.0 17.134918401649692 -5.5896439796081605 2.0478933748158292 0.9673090796716548 1.3917530071692767 0.6974070277905677 0.11130292615570585 0.19087914864618766 1.595362955195151 0.034447810714499684 0.08122414159044876 2.5725037729561427e-06 5.5896439796081605 0.42444392749762194 KVESLQEEIAFLKK ddPTM_A459_Selumetinib_30min_R1 1 KVESLQEEIAFLKK 14 2 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 108.32 0.0031221 7159800.0 1162.7 1231.4 1934.7 1578.0 1533.3 1175.2 1232.0 1231.7 768.53 993.76 False True 1189.7886477796333 1087.2271155376716 1671.978366546395 1302.431922728613 1394.6132857261011 1163.3785549962251 1139.06924811111 1199.0313148745438 1304.1392787896505 1121.318776042119 1.0610619149526686 0.9695968165049553 1.4910821099847453 1.1615179827147486 1.243725972955363 1.0375092077763677 1.0158299962938677 1.069304590713021 1.163040614902416 1.0 10.130980760162851 -6.770532904587376 24.975957442690508 1.058886719217027 1.189063962877687 0.18888963579370377 0.1327581036701519 355.69993899452226 976947.3587354928 0.04828922170739815 0.043182432974511055 1.6961610867081798e-07 6.770532904587376 0.13017724366065986 KVEVVS(ph)PATPVPSETAPASVFPQNGAAR ddPTM_A459_Selumetinib_30min_R2 2 KVEVVSPATPVPSETAPASVFPQNGAAR 28 1 E9PRM3;E9PRL6;Q92993-2;Q92993-4;Q92993;Q92993-3 E9PRM3 KAT5 Histone acetyltransferase KAT5 1 KVEVVS(0.824)PAT(0.176)PVPSETAPASVFPQNGAAR;KVEVVS(0.996)PAT(0.004)PVPSETAPASVFPQNGAAR 80.721 3.2145e-05 6714700.0 25250.0 21353.0 24652.0 30876.0 30043.0 22629.0 19631.4 21654.0 19545.2 25560.0 True False 23846.706083758647 22990.70643928341 23065.917159068173 26670.63553592914 26268.72975217228 25745.93934439052 20544.298998881124 21717.009554987333 23454.786138516865 24822.01638714452 0.9607078535371932 0.9262223536034101 0.9292523540115846 1.0744749789844645 1.0582834747372507 1.0372219139185046 0.8276643878746752 0.8749091619420053 0.9449186469260511 1.0 14.59933269540349 -7.248537080350057 24.997996920691378 0.9014488089620052 0.997578270713135 0.30099983331868907 0.06327703675867773 959.0721708551969 1858189.0752101317 0.0263249411364982 0.020261102824984018 5.642387642096246e-08 7.248537080350057 0.0961294617511298 KVEVVSPAT(ph)PVPSETAPASVFPQNGAAR ddPTM_A459_Selumetinib_30min_R2 2 KVEVVSPATPVPSETAPASVFPQNGAAR 28 1 E9PRM3;E9PRL6;Q92993-2;Q92993-4;Q92993;Q92993-3 E9PRM3 KAT5 Histone acetyltransferase KAT5 1 KVEVVS(0.316)PAT(0.684)PVPSETAPASVFPQNGAAR;KVEVVS(0.21)PAT(0.79)PVPSETAPASVFPQNGAAR 110.38 7.2406e-10 9410700.0 32542.9 30694.1 34023.1 39489.1 40604.0 31356.7 30574.9 29893.3 30379.4 29395.7 True False 30734.295897550448 33048.238772912904 31834.090787550384 34110.616457502874 35502.96251563437 35675.800797218166 31996.693433015003 29980.284553897778 36456.12887135765 28546.96976179905 1.0766220076597564 1.1576793981523517 1.115147809143305 1.1948944753901334 1.2436683406987623 1.2497228635789837 1.1208437778160365 1.0502089995561197 1.2770577464282205 1.0 14.80104999233043 -10.870216741293742 4.387909777176476 0.9997750490956447 1.164402997636014 0.3192511904656171 0.07231718619510391 0.00016303607049660525 2.4250059629410103e-05 0.07173351446711833 0.017374250636463754 1.3482898300262765e-11 10.870216741293742 0.16462794854036922 KVGDDIAK ddPTM_A459_Selumetinib_30min_R2 1 KVGDDIAK 8 1 P30050 P30050 RPL12 60S ribosomal protein L12 0 101.65 0.022817 17557000.0 125040.0 99210.0 92712.0 97793.0 121830.0 76895.0 127710.0 162530.0 107130.0 154540.0 False True 118090.77737477943 106819.08798957094 86747.01085719334 84473.42469766526 106524.62622598102 87486.58826668914 133648.76805256432 163002.93539171023 128558.99346229795 150078.02865685904 0.7868625303227043 0.7117570036437774 0.5780127286688526 0.5628633681670135 0.7097949458647324 0.5829406812553486 0.8905285420435601 1.086121245398305 0.8566143532990923 1.0 17.1953532570719 -7.403569128623251 4.421367533684033 0.9804093770466227 0.6535576760301244 0.7595920352520458 0.08442662621263779 0.11063555165898285 3.486306423602866 0.03747636913977967 0.02440650717674262 3.948488444645001e-08 7.403569128623251 -0.3268517010164983 KVIFSEEIT(ph)NLS(ph)QMT(ph)LNVQGPS(ph)CILK ddPTM_A459_Selumetinib_30min_R1 1 KVIFSEEITNLSQMTLNVQGPSCILK 26 1 Q6TGC4 Q6TGC4 PADI6 Protein-arginine deiminase type-6 4 KVIFS(0.005)EEIT(0.996)NLS(0.999)QMT(0.999)LNVQGPS(1)CILK 42.38399999999999 0.028417 12656000.0 2842.0 2778.2 2841.0 2497.0 3065.7 2501.7 2942.2 2754.3 1001.6 1848.1 True False 2908.2130704306487 2452.927052449859 2455.2078044959453 2060.9458244951506 2788.4079762932956 2476.5351693618586 2720.2674852211917 2681.2470167727197 1699.6420460303634 2085.3216370184346 1.3946112766511998 1.1762823580332775 1.1773760751873121 0.9883107660273759 1.3371596624682438 1.1876034494624896 1.3044834125015814 1.285771446080774 0.815050309678122 1.0 11.026054204708243 -8.258037948328719 24.999707499625384 0.9075251396895322 1.2242003733298263 0.5618166091524739 0.11428523741545163 203.87457349741948 1498459.4878250933 0.08460914451401014 0.02902533790934491 5.520292012723837e-09 8.258037948328719 0.31667523364029415 KVIS(ph)PPPFAPSPTLPPTFHPEEFLDEDLK ddPTM_A459_Selumetinib_30min_R1 1 KVISPPPFAPSPTLPPTFHPEEFLDEDLK 29 1 Q5TC82-2;Q5TC82 Q5TC82-2 RC3H1 Roquin-1 1 KVIS(0.937)PPPFAPS(0.014)PT(0.048)LPPT(0.002)FHPEEFLDEDLK 72.499 0.00012222 5484300.0 1146.2 1599.9 1209.2 1419.7 1411.4 1409.9 1317.5 1155.8 587.86 1525.2 True False 1172.9042298830443 1412.5829642266683 1044.9972816601546 1171.7760460695902 1283.7391192029083 1395.7176860867753 1218.119914274665 1125.14442943249 997.5554844043626 1720.9742767060857 0.6815350152286774 0.8208042289454361 0.6072126096272984 0.6808794657363205 0.7459374242710718 0.811004385700729 0.7078083215782429 0.6537834090036467 0.5796457843133287 1.0 10.749009818329622 -6.268781970630887 23.254902149739507 0.7333567025524985 0.699950772337142 0.03575757749244135 0.1148070302411729 1302.7434376927927 4125947.5382686257 0.03499031227869233 0.04054709714965317 5.385400785706005e-07 6.268781970630887 -0.03340593021535654 KVIYSQPS(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 KVIYSQPSAR 10 1 A0A087WY82;Q9Y624-2;Q9Y624 A0A087WY82 F11R Junctional adhesion molecule A 1 KVIYSQPS(1)AR 70.563 0.037816 10388000.0 81590.0 26028.0 69637.0 78659.0 31678.0 23867.0 89998.0 60458.0 39319.0 38793.0 True False 77055.55443064812 28024.26390678914 65156.63123503283 67945.50850565634 27698.326435086845 27154.462606945417 94183.08532765385 60633.92277063927 47183.89866465142 37672.94529368144 2.0453817409272745 0.7438830091017441 1.7295337735635177 1.8035624232717544 0.7352312440443154 0.72079478775183 2.5000191674275696 1.6094818787850091 1.2524611042971776 1.0 15.201241208016143 -7.220728963223782 24.999648776627655 1.6412836623328333 1.2885171146093226 0.056978165236912015 0.5708361060741477 1421.8793161654805 873155.5348327095 0.21905561689161848 0.16967800794018356 6.015490382375111e-08 7.220728963223782 -0.3527665477235107 KVNVTVDYIRPAS(ph)PATETVPAFSER ddPTM_A459_Selumetinib_30min_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 KVNVT(0.041)VDY(0.111)IRPAS(0.806)PAT(0.034)ET(0.008)VPAFS(0.001)ER 42.813 0.03261 67396000.0 2564.9 3475.0 3376.1 4265.1 3099.4 3214.8 2969.2 2545.4 1242.1 2270.8 True False 2624.6571795733876 3068.1453845163282 2917.6441635898495 3520.280350842718 2819.059817243514 3182.462030804856 2745.230853483366 2477.8877233755484 2107.752980605346 2562.279299465106 1.0243446840948618 1.1974281590444982 1.138690916403582 1.3738862705473214 1.1002156626063415 1.2420433757823426 1.0714018780296326 0.967063865322108 0.8226085973708465 1.0 11.323212028878384 -7.655856034011401 2.451890833118883 0.909892710165796 1.183349055920415 0.5755054021534081 0.09596579175840615 0.1984712327438575 2.393160292231132 0.05620561480396998 0.027023843937702158 2.208736794535998e-08 7.655856034011401 0.27345634575461897 KVPCS(ph)PDFQR ddPTM_A459_Selumetinib_30min_R2 1 KVPCSPDFQR 10 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 KVPCS(1)PDFQR 84.352 0.019504 35225000.0 90243.0 89130.0 97416.0 113010.0 105930.0 75155.0 79416.0 73824.0 70952.0 95286.0 True False 85227.65533135172 95965.9844018793 91148.36061852102 97617.84304687606 92622.12637378469 85506.91906083637 83109.00135981859 74038.81561777889 85144.3825645198 92534.84559724001 0.9210330960328934 1.0370794243238206 0.9850166175804335 1.0549306309080573 1.0009432206427897 0.9240510264966254 0.8981373538088817 0.8001182164396156 0.920133188908237 1.0 16.49770911927388 -6.88016147929202 3.0255408070752483 0.8895837029688113 1.004732774427578 0.3843225460894474 0.05674586635679343 0.22636792607821965 4.153048820752916 0.020956402580997468 0.018241785787853265 1.3177666756986986e-07 6.88016147929202 0.11514907145876674 KVPPPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 KVPPPSPK 8 1 A0A075B754;Q96QE3 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 KVPPPS(1)PK 65.695 0.043209 15323000.0 123010.0 105430.0 84742.0 82569.0 87869.0 70687.0 109240.0 139790.0 74681.0 124800.0 True False 116173.59664804563 113516.14198911867 79289.79198011335 71322.9597605303 76830.1106611733 80423.49261730218 114319.87645495353 140196.76575651954 89619.28676148519 121196.69973065874 0.9585541265250935 0.9366273359042866 0.6542240189404734 0.5884892898819418 0.6339290659887319 0.6635782393087533 0.943258988974222 1.15677049018732 0.7394531943580183 1.0 16.886990888206107 -7.335908921874219 6.15620141354255 0.9760849261156892 0.733000731917024 0.34141120022866 0.14961814803910575 0.2821945937211286 18.602117026893456 0.0679391524291823 0.04553037903141579 4.614143299828616e-08 7.335908921874219 -0.24308419419866523 KVPS(ph)FTFTPTVTYQR ddPTM_A459_Selumetinib_30min_R1 1 KVPSFTFTPTVTYQR 15 1 A0A0A0MSX4;Q9Y6N7-4;Q9Y6N7-3;Q9Y6N7;Q9Y6N7-2 A0A0A0MSX4 ROBO1 Roundabout homolog 1 1 KVPS(0.974)FT(0.026)FTPTVTYQR 73.76 0.021671 11664000.0 2692.9 2323.9 3470.7 2465.8 2865.3 2545.9 2344.8 3144.7 1279.7 2249.6 True False 2755.639330528746 2051.8167076481996 2999.398003190452 2035.1943187986146 2606.134120909801 2520.2905574922474 2167.9298481906894 3061.2923405747997 2171.557434409998 2538.358072959618 1.0855991358680879 0.8083243768897697 1.1816291937462082 0.8017758961901165 1.02670074355237 0.9928822037915618 0.8540677815651813 1.2060128053586476 0.8554968889310618 1.0 11.309679881676042 KVPT(ph)IILS(ph)VS(ph)Y(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KVPTIILSVSYK 12 1 R4GN78;F8VR14;H0YI72;Q7Z6G8-9;Q7Z6G8-8;Q7Z6G8-10;Q7Z6G8-7;Q7Z6G8-2;Q7Z6G8-5;Q7Z6G8-4;Q7Z6G8-3;Q7Z6G8-6;Q7Z6G8 R4GN78 ANKS1B Ankyrin repeat and sterile alpha motif domain-containing protein 1B 4 KVPT(1)IILS(1)VS(1)Y(1)K 67.685 0.030918 2239200.0 633.42 884.25 656.76 658.64 489.81 665.22 691.96 695.16 623.95 863.81 True False 648.1774535792334 780.7215989233274 567.5755993244485 543.6208882040395 445.50677198297916 658.5284907714341 639.7649000998078 676.7220986020849 1058.7975784950536 974.688427721927 0.6650098997216726 0.800996068813554 0.5823149051343559 0.5577381168612082 0.45707608637996433 0.6756297418145899 0.6563788816033107 0.6942958173657006 1.0862933716877188 1.0 9.928797305439263 -8.188288873327503 4.131503844194527 1.045607393023932 0.6284597013107597 0.7786281874546663 0.08716205220774711 0.10591685419563072 3.3443918352208604 0.07437420933730751 0.024765246629320357 6.48203134297094e-09 8.188288873327503 -0.41714769171317234 KVQAEDEANGLQTTPAS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 KVQAEDEANGLQTTPASR 18 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 KVQAEDEANGLQTTPAS(0.999)R;KVQAEDEANGLQTT(0.123)PAS(0.877)R;KVQAEDEANGLQT(0.001)T(0.04)PAS(0.959)R 196.11 1.4093000000000002e-10 41552100.0 6386.299999999999 10193.400000000001 8227.1 7891.2 7349.5 7462.299999999999 7608.6 6762.5 4427.11 5081.200000000001 True False 6535.088364423379 8999.951989216903 7109.90500822548 6513.150056169853 6684.739022659616 7387.23603722629 7034.677176280995 6583.136532304215 7512.482326678797 5733.4215150793125 1.139823462697732 1.569734924520442 1.2400806376307614 1.1359970724356823 1.1659249202379889 1.2884515847644074 1.2269597059590485 1.1482038282010298 1.310296531821431 1.0 12.48518063300961 -14.522878745247851 0.11455359673072098 0.24518460115790996 1.3734155627176903 0.2590972814726382 0.12339304722721486 222.90995045973955 1.672477456557104 39.76003688898998 1.3839127503276427 3.0000000002244067e-15 14.522878745247851 1.1282309615597803 KVQAEDEANGLQTTPAS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 KVQAEDEANGLQTTPASR 18 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 KVQAEDEANGLQTTPAS(1)R;KVQAEDEANGLQTTPAS(1)R 167.36 6.748300000000001e-08 55888000.0 152461.0 87620.0 148136.0 173179.0 174709.0 180439.0 83683.0 100046.0 59604.0 134486.0 True False 143987.82796973974 94340.17225729457 138605.0910382818 149591.72144956203 152760.49350172322 205292.83438784198 87574.42531471868 100337.11729649318 71526.46547490748 130603.03974340858 1.1024845076548586 0.7223428523764956 1.0612700233516354 1.1453923411236053 1.1696549621038428 1.5718840448979898 0.6705389513657051 0.7682601989480655 0.5476630989250567 1.0 16.99482894997128 -1.799588529193235 6.521873146337692 0.9829920612901462 0.8954106694180359 0.0 0.28807843481197315 0.0 0.0 0.06994137218936824 0.0 0.01586395505610189 1.799588529193235 -0.08758139187211023 KVQVAALQAS(ph)PPLDQDDR ddPTM_A459_Selumetinib_30min_R1 1 KVQVAALQASPPLDQDDR 18 1 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;Q9UDY2-5;A0A3B3IRV6;A0A3B3ISF1;A0A3B3ISZ5;A0A3B3IRI3;A0A3B3IU26;B1AN86;U3KQJ2 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 KVQVAALQAS(1)PPLDQDDR 85.881 0.0038334 22686000.0 2511.3 2907.9 3139.7 3134.3 3186.4 2583.1 2908.0 2573.1 1630.5 1850.1 True False 2569.808403860833 2567.4417161539664 2713.3459851376006 2586.953343097777 2898.1906826046115 2557.116359267148 2688.647218755768 2504.8530293932686 2766.8394129917183 2087.578356500083 1.2309997351041855 1.2298660350447375 1.2997576721798576 1.2392125713714135 1.3883027066172289 1.2249199419533483 1.2879263719055813 1.19988455599471 1.325382304514043 1.0 11.02761463430268 -11.163547173136086 2.9698217528742274 0.9769678945079084 1.2690772219322728 0.6906316672800522 0.05412795927983748 33244542.790229972 29595862.63739554 5804001.481978572 0.013362499852322938 6.862033388468786e-12 11.163547173136086 0.29210932742436435 KVQVAALQAS(ph)PPLDQDDR ddPTM_A459_Selumetinib_30min_R2 3 KVQVAALQASPPLDQDDR 18 1 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;Q9UDY2-5;A0A3B3IRV6;A0A3B3ISF1;A0A3B3ISZ5;A0A3B3IRI3;A0A3B3IU26;B1AN86;U3KQJ2 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 KVQVAALQAS(1)PPLDQDDR;KVQVAALQAS(1)PPLDQDDR;KVQVAALQAS(1)PPLDQDDR 113.7 0.00058877 32180000.0 260309.0 252464.0 277969.0 270880.0 262525.0 203575.0 203808.0 212656.0 198684.0 250959.0 True False 245842.06787949015 271827.17700029264 260084.77716976372 233985.6767059361 229544.2624967223 231615.6083801451 213285.47583789052 213274.79375290425 238426.35169479388 243713.1616002117 1.0087352946607402 1.115356984479153 1.0671757547358403 0.9600863374369882 0.941862396718926 0.9503615104714308 0.8751495997896294 0.8751057692270281 0.9783072449977472 1.0 17.89482463958351 -5.836769959214008 3.3439072541948143 0.9294504639950083 1.0707067052233317 0.6185550692059565 0.04445005484337408 0.14331311652210085 3.1966924877661635 0.01295866824704011 0.021036382967867143 1.4562302247118178e-06 5.836769959214008 0.14125624122832336 KVS(ph)VSESNVLLDEEVLTDPK ddPTM_A459_Selumetinib_30min_R1 2 KVSVSESNVLLDEEVLTDPK 20 1 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 KVS(0.553)VS(0.168)ES(0.279)NVLLDEEVLTDPK;KVS(0.772)VS(0.221)ES(0.006)NVLLDEEVLTDPK 139.75 3.7806e-05 20308500.0 8208.4 11245.6 8206.8 7754.3 6922.6 8479.3 7512.2 8984.9 5480.5 7710.6 True False 8399.639749233964 9928.9599240624 7092.361636725562 6400.157071238584 6296.452052284294 8394.005940588408 6945.548705893086 8746.591264931627 9300.008220117212 8700.330617604212 0.9654391446042486 1.1412163928543342 0.8151830026292228 0.7356222829381373 0.7237026187883113 0.9647916049999309 0.7983085943699073 1.0053171137236798 1.068925840737548 1.0 13.08685450991255 -7.896816602209243 6.524539827394705 1.0350828506849816 0.8777803070482963 0.24495886346983464 0.11887362950961912 0.3314958698443829 18.03124862517751 0.07294334349377357 0.034605673471283384 1.2681872943656536e-08 7.896816602209243 -0.15730254363668528 KVS(ph)VSESNVLLDEEVLTDPK ddPTM_A459_Selumetinib_30min_R2 1 KVSVSESNVLLDEEVLTDPK 20 1 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 KVS(0.463)VS(0.463)ES(0.074)NVLLDEEVLTDPK 122.19 0.0001249 3985700.0 42935.0 28934.0 35680.0 39492.0 36331.0 31024.0 38454.0 42253.0 31099.0 45411.0 True False 40548.84458242284 31153.14476252642 33384.38764544669 34113.12147250012 31766.77497673904 35297.27439216807 40242.187195155464 42375.94923463931 37319.66897866155 44099.8664380524 0.9194777185863426 0.706422655639731 0.7570178855834434 0.7735425122073606 0.7203372151106672 0.8003941336591248 0.9125240152752875 0.9609087885598316 0.8462535602252885 1.0 15.428486665956934 -7.232261123682544 3.5396877622175604 0.9292693261526974 0.7697834655408105 0.5652572425243754 0.0648938840322773 0.17246873232913507 4.592425148608485 0.026320588811790148 0.018789740552948884 5.857858493020224e-08 7.232261123682544 -0.15948586061188696 KVSGDS(ph)SHTETTAEEVPEDPLLK ddPTM_A459_Selumetinib_30min_R2 1 KVSGDSSHTETTAEEVPEDPLLK 23 1 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7C231;H7C2V9 H7BYY2 BCOR BCL-6 corepressor 1 KVS(0.068)GDS(0.287)S(0.287)HT(0.287)ET(0.064)T(0.005)AEEVPEDPLLK 59.857 0.006093 4072400.0 16570.0 17866.0 19243.0 25931.0 25579.0 17561.0 18260.0 21378.0 18544.0 21252.0 True False 15649.105734965564 19236.264751755607 18004.92633019426 22399.153066529936 22365.537340838622 19979.868347113956 19109.126181503565 21440.206440681573 22253.318162651536 20638.399540672737 0.7582519034058519 0.9320618449044995 0.8723993493154055 1.0853144412863618 1.0836856461065287 0.9680919447139787 0.9259015527751856 1.0388502460391218 1.0782482487944973 1.0 14.333043477042203 -4.658661879121841 0.9988723147734151 1.0192474492264156 0.5924349818310094 0.6157625729624041 0.06234149809376881 1.7155773209680716 1.1698278589567765 0.021778436088555276 0.8351425427927877 2.1945128129734786e-05 4.658661879121841 -0.42681246739540624 KVSGDSSHTET(ph)TAEEVPEDPLLK ddPTM_A459_Selumetinib_30min_R2 1 KVSGDSSHTETTAEEVPEDPLLK 23 1 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7C231;H7C2V9 H7BYY2 BCOR BCL-6 corepressor 1 KVS(0.203)GDS(0.203)S(0.203)HT(0.06)ET(0.254)T(0.078)AEEVPEDPLLK 47.089 0.036833 8042200.0 25179.0 21545.0 24643.0 26697.0 30965.0 23602.0 23417.0 24040.0 22430.0 27310.0 True False 23779.651979523103 23197.432221906118 23057.496209269702 23060.822545106246 27074.899869387715 26852.961262375924 24505.936899905217 24109.95241996376 26916.62674656353 26521.489340098477 0.8966182733776596 0.8746655183814795 0.8693891928010438 0.8695146132023602 1.0208664951727475 1.0124982393721111 0.9240030446877696 0.9090723417071206 1.0148987638438403 1.0 14.694874173221782 -6.246627120473957 24.881773941488504 0.9744795137945397 0.8767583844596755 0.6551298428869591 0.03635069923843935 538.727730592837 904959.7761083636 0.011580126554624487 0.014883977946852504 5.667256634065014e-07 6.246627120473957 -0.09772112933486421 KVSGTLDT(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 KVSGTLDTPEK 11 1 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 KVSGT(0.003)LDT(0.997)PEK;KVSGTLDT(1)PEK 98.676 0.02248 56273000.0 193938.0 166678.0 167285.0 177788.0 153909.0 179252.0 172493.0 175495.0 138795.0 190968.0 True False 183159.70235532604 179461.6666457585 156522.0652261369 153572.96769859327 134573.5754560824 203942.33591235513 180514.26628839536 176005.66139523868 166557.8782563214 185454.2576455479 0.9876273787436718 0.967686959167889 0.8439928379821396 0.8280908168315649 0.7256429545731329 1.0996907728165661 0.9733627503629807 0.949051607818204 0.8981076000673843 1.0 17.50070386394723 -6.770316486569651 24.99999960219532 0.9801907455556336 0.8721607384644288 0.3171119537018401 0.08311888721733178 278.5170585343189 784364.1049303344 0.031466769313430995 0.02815998363235991 1.6970065298634483e-07 6.770316486569651 -0.1080300070912048 KVSSS(ph)SPQSGCPSPTIPAGK ddPTM_A459_Selumetinib_30min_R2 1 KVSSSSPQSGCPSPTIPAGK 20 1 E7EWD6;Q76L83;A0A5F9ZHC8 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 KVS(0.22)S(0.22)S(0.339)S(0.22)PQS(0.001)GCPSPTIPAGK 95.223 0.00054817 9572000.0 51601.0 51697.0 65235.0 71347.0 70741.0 53790.0 49872.0 47744.0 44244.0 62744.0 True False 48733.22299516945 55661.99366794526 61037.85112249765 61629.41551956004 61853.88314743597 61199.08424299639 52191.14681949322 47882.927135555285 53094.036280648965 60932.41769150999 0.7997913892387646 0.9135037764257451 1.0017303339500074 1.0114388670999208 1.015122745671954 1.0043764314890062 0.8565415389182114 0.7858366523051497 0.8713594223267923 1.0 15.894922364650318 -7.275383000575085 24.075274338286388 0.8605874403822563 0.9627130151181247 0.17911179434211177 0.07905702701714504 704.9302789386603 1217137.1866736813 0.03430839141781905 0.0232765034164508 5.3041646817973225e-08 7.275383000575085 0.10212557473586836 KVSSSSPQSGCPS(ph)PTIPAGK ddPTM_A459_Selumetinib_30min_R2 2 KVSSSSPQSGCPSPTIPAGK 20 1 E7EWD6;Q76L83;A0A5F9ZHC8 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 KVSSSSPQSGCPS(0.999)PT(0.001)IPAGK;KVSSSSPQS(0.001)GCPS(0.609)PT(0.39)IPAGK 141.36 3.057e-05 5949700.0 76903.0 73617.0 80098.0 75700.0 77087.0 56472.0 58283.0 60358.0 50337.0 71163.0 True False 72629.03912710067 79263.18718403636 74944.58188410864 65389.52941021627 67402.64189347612 64250.505398224464 60993.27498557355 60533.63178719523 60405.80653329324 69108.33928632093 1.0509446454239513 1.1469409915298812 1.0844506272044496 0.9461886956840715 0.9753185012046378 0.9297069798194671 0.8825747459054678 0.8759236933244763 0.8740740575898885 1.0 16.076572190323603 -5.8958128932251315 1.4267029707378964 0.9080708332068673 1.1105754985283973 0.7282417778876292 0.046432966718412905 0.20341403860291904 0.8408018166675449 0.015962147241553152 0.031925507127701785 1.2711216236585634e-06 5.8958128932251315 0.20250466532153 KVSVS(ph)ESNVLLDEEVLTDPK ddPTM_A459_Selumetinib_30min_R1 2 KVSVSESNVLLDEEVLTDPK 20 1 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 KVS(0.359)VS(0.551)ES(0.09)NVLLDEEVLTDPK;KVS(0.103)VS(0.449)ES(0.449)NVLLDEEVLTDPK 88.85600000000002 0.00098556 24147800.0 10805.900000000001 15405.5 10742.6 10834.6 9262.5 12136.3 10581.7 11849.5 7364.4 10222.1 True False 11057.656445378801 13601.816898177354 9283.813924877913 8942.540500630821 8424.7085104272 12014.219840878737 9783.513849624454 11535.212767399458 12496.848925505192 11534.206106685855 0.9586837917669236 1.1792590467317035 0.8048940550400351 0.775306112784584 0.7304107827190446 1.0416165386462655 0.8482173596632191 1.0000872761163007 1.0834598246221157 1.0 13.493631087049913 -7.9360286145236705 5.818360895302851 1.0420882101253117 0.9060171635551717 0.16820277365615044 0.1268318720567198 0.3694074158948904 23.653454706082726 0.07736995144576445 0.03606946215369078 1.1587010098713259e-08 7.9360286145236705 -0.13607104657014002 KVSVSES(ph)NVLLDEEVLTDPK ddPTM_A459_Selumetinib_30min_R2 1 KVSVSESNVLLDEEVLTDPK 20 1 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 KVS(0.009)VS(0.009)ES(0.981)NVLLDEEVLTDPK 130.95 8.287899999999999e-05 4223000.0 71889.0 55381.0 58919.0 63841.0 67057.0 55205.0 67197.0 74780.0 56347.0 72464.0 True False 67893.69717446824 59628.5446220182 55128.21568615682 55145.7456681323 58632.70016281395 62808.9876489053 70321.79364832946 74997.59741950459 67617.97446672367 70371.77603591696 0.9647858985371643 0.8473360767757866 0.7833853114353686 0.7836344167296067 0.8331848855553748 0.8925309433266015 0.9992897381535178 1.0657340434498435 0.9608678120076466 1.0 16.102709303619243 -7.146852976683683 2.716262090586059 1.014382895514774 0.8369806851324609 0.6811325470814308 0.05295763832600773 0.16623141834149166 2.378445817848307 0.024153769842937156 0.01766304328100386 7.13094395750744e-08 7.146852976683683 -0.17740221038231307 KVT(ph)SPLQSPTK ddPTM_A459_Selumetinib_30min_R2 1 KVTSPLQSPTK 11 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 KVT(0.732)S(0.268)PLQSPTK 100.18 0.020615 22472000.0 213320.0 175150.0 208900.0 224520.0 199140.0 112030.0 157860.0 163700.0 145720.0 159960.0 True False 201464.52838761927 188583.44180398478 195459.60143312268 193939.98868139653 174122.2528658122 127461.11559291466 165200.80279365557 164176.3398980063 174868.0717569875 155341.53917400795 1.2969134299741039 1.2139923603611296 1.258257144048096 1.2484747461150878 1.1208994953421105 0.8205217758923925 1.063468301344714 1.0568733950427898 1.1257006508806808 1.0 17.245084140266627 -6.440885191596507 4.199348181632781 1.015622924526769 1.2496528597705918 0.6821410832253587 0.07710790140030839 0.14171385895144079 4.58053836224183 0.02566943724261185 0.02876124913362018 3.6233877222832826e-07 6.440885191596507 0.23402993524382287 KVTAEADSS(ph)SPTGILATSESK ddPTM_A459_Selumetinib_30min_R1 1 KVTAEADSSSPTGILATSESK 21 1 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 KVT(0.001)AEADS(0.058)S(0.458)S(0.458)PT(0.024)GILATSESK 70.107 0.0033025 37139000.0 3091.4 3635.9 3830.2 4170.2 3705.2 2877.9 3583.4 3520.2 1723.2 3169.4 True False 3163.4236051827265 3210.2071377159464 3310.0798777826003 3441.952854349091 3370.065314206189 2848.9509389241307 3313.101252988108 3426.8328607789 2924.1445424515996 3576.2233625703298 0.8845710361080711 0.8976528623225263 0.9255797365530197 0.9624546638706776 0.9423531397613909 0.7966367449924916 0.9264245873632713 0.9582267418319032 0.8176627257280532 1.0 11.80422113136481 -10.613747288266987 4.516644047495187 1.0000074985993226 0.9042357409475207 0.235554083845954 0.05311100085379935 11587355.362789223 27229344.92798703 476.21992256401734 0.012866784001130074 2.4336196967670514e-11 10.613747288266987 -0.0957717576518019 KVTAEADSS(ph)SPTGILATSESK ddPTM_A459_Selumetinib_30min_R2 3 KVTAEADSSSPTGILATSESK 21 1 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 KVTAEADS(0.017)S(0.767)S(0.136)PT(0.079)GILAT(0.001)SESK;KVT(0.001)AEADS(0.094)S(0.479)S(0.388)PT(0.037)GILATSESK;KVTAEADS(0.006)S(0.612)S(0.336)PT(0.046)GILATSESK 80.847 0.0009744 72283900.0 309422.0 262448.0 315623.0 328905.0 301085.0 230094.0 263581.0 265623.0 218421.0 277615.0 True False 292225.5639544065 282576.9176966723 295316.15980433946 284107.5716072276 263260.0105659486 261787.35991463094 275838.038775843 266395.91895374516 262111.30319265038 269599.5336196062 1.083924590042966 1.0481357808852023 1.0953882443321223 1.0538132903749442 0.9764854079361932 0.9710230444389495 1.02313989595041 0.9881171357277597 0.9722246165398735 1.0 18.04045847523973 -6.1537679075100105 4.345652743985402 0.9888714515063431 1.0731243812552584 0.8290371311077235 0.018347746999241923 0.09214675694607874 2.9148575668983425 0.005547030334489442 0.007280728812837961 7.018302652298823e-07 6.1537679075100105 0.0842529297489153 KVTAEADSSS(ph)PTGILATSESK ddPTM_A459_Selumetinib_30min_R2 1 KVTAEADSSSPTGILATSESK 21 1 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 KVTAEADS(0.001)S(0.018)S(0.972)PT(0.009)GILATSESK 89.08 0.00042897 9887200.0 52214.0 51708.0 54279.0 58919.0 56060.0 41632.0 43674.0 48736.0 37117.0 46607.0 True False 49312.15490920293 55673.83733257471 50786.7482345068 50894.13055905589 49017.24161724124 47366.43010233179 45704.92753838923 48877.81369132087 44541.43713563078 45261.33481047124 1.0894984674158246 1.2300529263156978 1.122078004265072 1.124450500016661 1.0829826787587595 1.0465097925343008 1.0098006992011062 1.0799021702738858 0.9840946433008443 1.0 15.465991511570321 -6.411210884621473 1.0548625721134055 1.0208108003964795 1.1599319780081294 0.6605111980770064 0.040331866135566184 0.30016634006737747 0.7085552970081919 0.018086028067553373 0.023508720451728787 3.879619337722345e-07 6.411210884621473 0.13912117761164988 KVTGTEGSSSTLVDYTSTSSTGGS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 KVTGTEGSSSTLVDYTSTSSTGGSPVR 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 KVTGTEGSSSTLVDYTST(0.005)S(0.186)S(0.186)T(0.31)GGS(0.313)PVR 157.67 3.1459000000000005e-17 14839000.0 4365.0 6004.1 5148.7 5577.9 5807.0 4791.2 5512.2 5222.9 2381.0 3889.0 True False 4466.696007188524 5301.137180769638 4449.53481978468 4603.824475150783 5281.757875309118 4743.004878061536 5096.410316102318 5084.371725629827 4040.383098640469 4388.191032067903 1.0178900541355025 1.20804612698721 1.0139792883373788 1.0491394840167805 1.203629886828361 1.080856517731506 1.1613920813517256 1.1586486751543845 0.9207400200023809 1.0 12.099410616925077 -8.262749229155867 24.989584768961702 0.9603699993400833 1.1132596586264658 0.4287970112676567 0.06984449813542097 106.78780814321561 2037193.5707863525 0.05469809092196578 0.017061322075178163 5.460730842539132e-09 8.262749229155867 0.15288965928638254 KVTGTEGSSSTLVDYTSTSSTGGS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 KVTGTEGSSSTLVDYTSTSSTGGSPVR 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 KVTGTEGSSSTLVDYTST(0.034)S(0.385)S(0.074)T(0.074)GGS(0.432)PVR;KVTGTEGSSSTLVDYTS(0.003)T(0.01)S(0.063)S(0.063)T(0.063)GGS(0.799)PVR 167.41 9.744199999999996e-22 36217000.0 237580.0 203093.0 266710.0 246000.0 276920.0 199658.0 205454.0 232160.0 209820.0 225270.0 True False 224376.25470809417 218669.58005307862 249550.16897189154 212494.3756263306 242130.8339037893 227159.07718513077 215008.01809937775 232835.5471638429 251789.8628606307 218765.86977824944 1.0256456134383836 0.9995598503310026 1.1407180161368242 0.9713323922133015 1.1068035162396381 1.03836616477419 0.982822495654003 1.0643138593778594 1.1509558740394734 1.0 17.739028151587142 -7.997658213893131 24.99316837137756 1.0861969194297083 1.039273586814311 0.058714909596153775 0.06003445034782457 161.2847515303085 1721352.6148331265 0.031365549346465224 0.01492197790929 1.005406725650138e-08 7.997658213893131 -0.04692333261539727 KVTPIDS(ph)PPVWSPEGYMALQSK ddPTM_A459_Selumetinib_30min_R1 1 KVTPIDSPPVWSPEGYMALQSK 22 1 Q5JSZ5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 KVT(0.092)PIDS(0.897)PPVWS(0.011)PEGYMALQSK 52.721 0.018739 5773900.0 760.83 985.27 1041.9 1261.3 972.26 864.71 881.91 905.85 610.61 872.17 True False 778.5558586825299 869.9141303604032 900.4157027470345 1041.0376325333334 884.3192546664453 856.0118024938619 815.3868186701858 881.8239153845138 1036.1605728101042 984.1215151552236 0.7911176076256495 0.8839499157003933 0.9149436211696008 1.057834440667759 0.8985874620645432 0.8698232782349492 0.8285428233337387 0.8960518612840462 1.0528786911509322 1.0 9.942692654209324 -1.5229773045822288 0.01865681256583843 1.6444770271079954 2.6387895255584446e-06 0.208405281999393 0.07596587659758774 7412.840963520408 10.703518490474059 357.1602482910486 619.5464168999356 0.029993192537096727 1.5229773045822288 -1.6444743883184698 KVTS(ph)PLQSPTK ddPTM_A459_Selumetinib_30min_R1 1 KVTSPLQSPTK 11 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 KVT(0.398)S(0.602)PLQSPTK 139.74 0.0089098 0.0 2838.0 3499.2 3579.9 3763.7 3264.8 3012.3 3072.0 3269.3 1818.1 2736.3 True False 2904.1198782132956 3089.5120372660535 3093.7692429831163 3106.4404483990397 2969.4994164472573 2981.9989969495655 2840.2765667186104 3182.587543816958 3085.182911229835 3087.5307588190803 0.9405962580026456 1.0006417032255674 1.0020205415431787 1.0061245348004864 0.9617716059881561 0.9658200127826811 0.919918468376639 1.0307873159567273 0.9992395711095221 1.0 11.592237793950401 KVTS(ph)PLQSPTK ddPTM_A459_Selumetinib_30min_R2 1 KVTSPLQSPTK 11 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 KVT(0.352)S(0.648)PLQSPTK 85.163 0.018102 33524000.0 225190.0 163480.0 210390.0 204760.0 174310.0 125990.0 145180.0 173970.0 135870.0 151740.0 True False 212674.84130699455 176018.39032894897 196853.7364553119 176871.33476929794 152411.61944882857 143343.97887665225 151931.15766871232 174476.2238977159 163047.79652499256 147358.87193213234 1.4432442276359454 1.194487905757151 1.33587977346878 1.2002761180932349 1.0342887228332158 0.9727543173828774 1.0310282351963564 1.1840225268423115 1.10646745857342 1.0 17.168974396840888 -6.035809756524111 3.1590010299603093 1.0592378823693769 1.3107879532979199 0.7010331115141852 0.07915303285617349 0.15438157169628064 3.117659263795107 0.02494549495139364 0.035729709468937484 9.20852864662316e-07 6.035809756524111 0.251550070928543 KVTSPSSSSSSSSSDSES(ph)DDEADVSEVTPR ddPTM_A459_Selumetinib_30min_R1 1 KVTSPSSSSSSSSSDSESDDEADVSEVTPR 30 1 P56181-2 P56181-2 NDUFV3 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 1 KVTSPSSSSSS(0.001)S(0.002)SS(0.001)DS(0.09)ES(0.904)DDEADVS(0.002)EVTPR 105.87 4.599600000000001e-11 10298000.0 3250.9 4745.0 4705.2 4599.1 4957.6 4272.9 4654.7 4055.5 2298.8 3326.2 True False 3326.6396448497535 4189.453194109347 4066.25968381356 3795.953520799216 4509.185955335369 4229.918505482787 4303.592231479531 3947.934965879444 3900.8957022909344 3753.1501699316686 0.8863593232962271 1.116249817999055 1.0834257889253582 1.0114046464781683 1.2014403237740592 1.1270315105882902 1.146661347568164 1.0518990147285585 1.0393657396239906 1.0 11.873886300728008 -4.757383502020468 24.99300816275952 1.092321794249008 0.8863590226800465 0.49629692504742084 0.060187495390828676 100.12449997960695 616900.1071429772 0.015099617075048602 0.11254694416186378 1.7483021754820678e-05 4.757383502020468 -0.20596277156896148 KVVDYSQFQES(ph)DDADEDYGR ddPTM_A459_Selumetinib_30min_R1 22 KVVDYSQFQESDDADEDYGR 20 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(0.996)DDADEDY(0.004)GR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDY(0.001)SQFQES(0.999)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYS(0.001)QFQES(0.999)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR 159.98 5.087300000000001e-07 1931922700.0 97652.23000000001 120366.39 105105.37000000001 114083.57 107832.68 100459.93 108418.16 100410.29999999997 58789.53 89911.52 True False 99927.33696083727 106273.8371019835 90832.63805647094 94161.01611333615 98079.23313340596 99449.39431451846 100240.09090323852 97747.09266537902 99761.53859261535 101452.53940436976 0.9849663453227787 1.047522691161007 0.8953214832250773 0.9281287256697337 0.9667499079789568 0.9802553479527293 0.9880491064270096 0.9634760572702714 0.9833320997021631 1.0 16.63044545131295 -6.727375658553469 5.119425687898107 0.98113002503588 0.9630767148847673 0.05571826989617301 0.03761375427183217 0.7618636057619839 48.74326363441606 0.013884580302818505 0.013450879915731653 1.873373365704103e-07 6.727375658553469 -0.018053310151112667 KVVDYSQFQES(ph)DDADEDYGR ddPTM_A459_Selumetinib_30min_R2 20 KVVDYSQFQESDDADEDYGR 20 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(0.999)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYS(0.001)QFQES(0.999)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(0.956)DDADEDY(0.043)GR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDY(0.001)S(0.001)QFQES(0.999)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(1)DDADEDYGR;KVVDYSQFQES(0.998)DDADEDY(0.002)GR 138.25 9.3399e-05 4114741500.0 2131220.3 2057771.7 2119109.3 2174967.5 2318032.2 1624187.6 1563756.4 1683076.8 1398558.7000000002 2129075.0 True False 2012775.6076768276 2215596.172611122 1982768.1147497552 1878733.174471791 2026820.2715652045 1847904.6989929364 1636474.171124522 1687974.274839635 1678309.5189950524 2067603.0727488182 0.9734825964448297 1.0715771328708423 0.9589694177198734 0.9086527289660437 0.9802753237692793 0.8937424805314305 0.7914837198171104 0.8163918389788047 0.8117174621741051 1.0 20.97952782077006 -6.449018636432255 0.9836886813796426 0.8414899405376167 1.007852596189536 0.41643287479720525 0.06711084744112214 0.4671849452874303 0.972925266669038 0.033494999256101804 0.04259008565137612 3.556160580555534e-07 6.449018636432255 0.1663626556519192 KVVDYSQFQES(ph)DDADEDYGRDSGPPTK ddPTM_A459_Selumetinib_30min_R1 3 KVVDYSQFQESDDADEDYGRDSGPPTK 27 2 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 KVVDYS(0.001)QFQES(0.995)DDADEDY(0.004)GRDSGPPTK;KVVDYSQFQES(0.999)DDADEDYGRDSGPPTK;KVVDY(0.02)S(0.023)QFQES(0.956)DDADEDY(0.001)GRDSGPPTK 101.59 9.5583e-07 87396000.0 4509.5 4560.9 9799.5 10243.7 6798.5 5814.6 5135.5 5561.9 3543.0 3617.26 True False 4614.562576040467 4026.907707695116 8468.781724800427 8454.830093064067 6183.57687537266 5756.11040323439 4748.12510038523 5414.380344402635 6012.212229518344 4081.5705560961565 1.1305850315752215 0.9866073983899661 2.074883089342071 2.071464887562973 1.5149993832979285 1.4102685042739669 1.1633083478842527 1.3265433660863266 1.473014406314407 1.0 11.994908681343668 -6.900924846967634 3.1651211084046573 1.2695412414042537 1.5823113117102587 0.1536420131394549 0.3426948723695881 0.5630850158493191 11.267920977082584 0.14509401692158538 0.1252375456555912 1.256247333779514e-07 6.900924846967634 0.312770070306005 KVVDYSQFQES(ph)DDADEDYGRDSGPPTK ddPTM_A459_Selumetinib_30min_R2 4 KVVDYSQFQESDDADEDYGRDSGPPTK 27 2 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 KVVDY(0.002)S(0.002)QFQES(0.995)DDADEDY(0.001)GRDS(0.001)GPPTK;KVVDYSQFQES(0.986)DDADEDY(0.014)GRDSGPPTK;KVVDY(0.001)S(0.002)QFQES(0.996)DDADEDYGRDSGPPTK;KVVDY(0.003)S(0.007)QFQES(0.989)DDADEDY(0.001)GRDSGPPTK 116.2 9.5148e-12 189146000.0 125515.3 188038.0 171158.0 188100.0 162002.0 83628.4 54491.2 50637.2 39691.6 163192.0 True False 118539.6621035561 202459.90996253354 160145.88062273973 162480.4555094011 141649.8604437443 95147.45299696969 57025.14877226435 50784.545868560235 47631.029075965256 158480.22293626302 0.747977633469319 1.2775089926770111 1.0105101927269915 1.025241209906342 0.8938014966114259 0.600374300553803 0.35982501611698586 0.3204472137131242 0.30054872585029946 1.0 17.27394328923681 -6.767987951361877 2.254887754435052 0.43913657702308717 1.0315644159400736 0.5324952466744413 0.22324891617005072 0.2035912045617705 2.126083225165309 0.0827314350403039 0.07599695554824042 1.7061297215282062e-07 6.767987951361877 0.5924278389169865 KVVDYSQFQES(ph)DDADEDYGRDSGPPTKK ddPTM_A459_Selumetinib_30min_R1 1 KVVDYSQFQESDDADEDYGRDSGPPTKK 28 3 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 KVVDYSQFQES(1)DDADEDYGRDSGPPTKK 92.886 4.7421e-06 74655000.0 1750.4 1118.4 7291.4 6351.9 3553.8 2508.4 1669.0 1783.4 1397.7 813.1 True False 1791.1809143144992 987.4572080699459 6301.267928793292 5242.659904930214 3232.35941747435 2483.167773444974 1543.105986280391 1736.0984387003825 2371.7948160309898 917.4693052646984 1.9523060924612916 1.076283645026201 6.868096722838393 5.714261910285552 3.5231254047695733 2.7065404359533938 1.6819156536634114 1.8922686881600927 2.58514895530669 1.0 9.841516081917868 -6.8815429857022465 2.7283152361745358 1.8846741772551545 3.9676805852720856 0.26631549520197295 1.5915319592570276 0.42751811991073363 6.443633667320819 0.6851431066869053 0.5925855071910391 1.3135814725468969e-07 6.8815429857022465 2.083006408016931 KVYEDSGIPLPAES(ph)PK ddPTM_A459_Selumetinib_30min_R1 5 KVYEDSGIPLPAESPK 16 1 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVYEDS(0.008)GIPLPAES(0.992)PK;KVYEDS(0.001)GIPLPAES(0.999)PK;KVYEDSGIPLPAES(1)PK;KVYEDSGIPLPAES(1)PK;KVY(0.011)EDS(0.059)GIPLPAES(0.93)PK 200.99 1.1598e-06 667039800.0 27908.0 37578.700000000004 36434.600000000006 37819.4 25366.0 32090.1 29572.500000000004 28824.699999999997 22345.6 33393.799999999996 True False 28558.202100485058 33178.96833413632 31486.981440932068 31214.951748062427 23071.649778731044 31767.30272947957 27341.82251604367 28060.175320178838 37918.85114194894 37680.219513157404 0.7579096531142271 0.8805407389559047 0.8356368897993616 0.8284174601786118 0.6123013633366639 0.8430763711020014 0.7256280050729611 0.7446924588743603 1.0063330742727814 1.0 15.201519749214082 -8.266598509072873 24.717753359244337 1.0031665901275477 0.7803403198079846 0.6064955937703025 0.07236680864563153 271.0592590223411 1298637.8166710432 0.06427910526529976 0.018632794742217875 5.412544636312736e-09 8.266598509072873 -0.22282627031956315 KVYEDSGIPLPAES(ph)PK ddPTM_A459_Selumetinib_30min_R2 7 KVYEDSGIPLPAESPK 16 1 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVYEDSGIPLPAES(1)PK;KVYEDS(0.005)GIPLPAES(0.995)PK;KVYEDSGIPLPAES(1)PK;KVYEDSGIPLPAES(1)PK;KVYEDSGIPLPAES(1)PK;KVYEDSGIPLPAES(1)PK;KVYEDSGIPLPAES(0.999)PK 151.21 0.00010657 505026000.0 2682873.0 2493143.0 2216780.0 1912314.0 1801452.0 1509748.0 2018963.0 1792942.0 1327511.0 1954672.0 True False 2533769.6590515557 2684359.0513817407 2074154.78824757 1651853.5342743471 1575137.4945747843 1717702.0828721954 2112848.7799992873 1798159.1643824752 1593050.2937564559 1898235.5405122275 1.3348025600489142 1.4141338069444125 1.092675141720227 0.8702047238187335 0.8297903294707795 0.9048940693675369 1.1130593305766194 0.947279263297985 0.8392268818897896 1.0 20.856227588050622 -5.435553664600605 3.320867346927125 0.9306580554448871 1.3739649593363543 0.822869898347649 0.08166202820574997 0.10039512386476825 2.088586969658702 0.024033991953702864 0.05480560574147719 3.6681436537663462e-06 5.435553664600605 0.4433069038914672 KVYEDSGIPLPAES(ph)PKK ddPTM_A459_Selumetinib_30min_R1 1 KVYEDSGIPLPAESPKK 17 2 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVYEDSGIPLPAES(1)PKK 60.325 0.023626 18349000.0 5514.4 6754.9 6969.2 6679.8 4613.6 6688.3 5459.4 5218.6 4029.3 6464.8 True False 5642.874790845448 5964.033167732183 6022.820919075376 5513.29832537553 4196.300694597237 6621.021774490515 5047.593062611845 5080.185775598197 6837.427811571626 7294.620052484596 0.7735666491530901 0.81759339414817 0.8256524501264412 0.7558033572286831 0.5752596659462681 0.9076582093176122 0.691961065318625 0.6964291133803264 0.9373247355416068 1.0 12.832617120561052 -8.401047501155265 4.521837787969426 0.9964524388260657 0.7573364898680369 0.5044943454200572 0.08532866117285996 0.17647467008594203 5.292666141658838 0.08196172254284266 0.021447344826712948 3.971481088398938e-09 8.401047501155265 -0.2391159489580288 KVYEDSGIPLPAES(ph)PKK ddPTM_A459_Selumetinib_30min_R2 2 KVYEDSGIPLPAESPKK 17 2 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVYEDSGIPLPAES(1)PKK;KVYEDS(0.001)GIPLPAES(0.998)PKK 58.98 0.025579 12180300.0 85810.0 71861.0 68969.0 71614.0 69731.0 58459.0 62957.0 62974.0 37187.0 70654.0 True False 81041.02372464677 77372.50763046637 64531.60962776947 61860.049658959375 60970.76837695057 66511.19661203437 65884.62524692877 63157.24391409308 44625.4390915942 68614.03543886173 1.1811143770556691 1.1276484051052331 0.9405015929323981 0.9015655363118751 0.8886049040400537 0.9693526431818592 0.9602208181682451 0.9204712054921926 0.650383537510449 1.0 16.066216098613495 -5.243371937411517 2.533332049522846 0.900390486668339 1.1791342458018566 0.5592205072569233 0.09021401064498243 0.22230581788426934 2.719359322870317 0.024692201309162973 0.08406744093789023 5.709894218600679e-06 5.243371937411517 0.27874375913351757 KVYEDSGIPLPAES(ph)PKKGPK ddPTM_A459_Selumetinib_30min_R1 1 KVYEDSGIPLPAESPKKGPK 20 3 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 KVYEDSGIPLPAES(1)PKKGPK 64.507 0.010985 25090000.0 2075.2 1707.4 6709.2 6874.9 2551.8 2997.7 1893.7 1843.3 1934.6 1124.8 True False 2123.5481223637175 1507.4968142512746 5798.1274909976055 5674.32777285611 2320.9901405568808 2967.5458596938283 1750.8566843733836 1794.4096961177625 3282.8749024064896 1269.179036479809 1.6731667174818645 1.1877731753531504 4.568407863936418 4.470864716292831 1.8287334362174559 2.3381617363651106 1.379519070240519 1.4138349630283302 2.5866129269766867 1.0 10.309679881676042 -6.466342476667617 24.999350175310358 1.7841427383141395 2.984776849264101 0.23554841111507008 1.0738952989666537 483.30297551193416 213707.776719609 0.36334900287648486 0.4119976800745716 3.417098700978808e-07 6.466342476667617 1.2006341109499614 KWDGS(ph)EEDEDNSK ddPTM_A459_Selumetinib_30min_R1 5 KWDGSEEDEDNSK 13 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KWDGS(1)EEDEDNSK;KWDGS(0.979)EEDEDNS(0.021)K;KWDGS(0.996)EEDEDNS(0.004)K;KWDGS(1)EEDEDNSK;KWDGS(1)EEDEDNSK 173.19 0.00028006 340234100.0 16467.800000000003 18646.199999999997 22885.799999999996 23721.399999999998 15426.1 15955.28 17139.19 15616.81 10759.99 15436.24 True False 16851.467699239212 16463.094235616794 19778.034062700906 19578.90279582669 14030.81197869916 15794.784369435132 15846.367099458957 15202.601468251945 18258.917151423975 17417.631765710434 0.967494773452163 0.9451970541728406 1.1355179813616985 1.1240852407025326 0.8055522224508842 0.9068273219858654 0.9097888457290286 0.8728282738288708 1.0483007906602868 1.0 14.088260856980433 -6.253340260910774 24.999133441745624 0.9159668391501377 1.0426857233131626 0.32778736747249326 0.08315606557973308 732.4312674144523 2260756.996714905 0.025607584379360854 0.03248745994685972 5.580328160367492e-07 6.253340260910774 0.1267188841630249 KWDGS(ph)EEDEDNSK ddPTM_A459_Selumetinib_30min_R2 8 KWDGSEEDEDNSK 13 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KWDGS(0.998)EEDEDNS(0.002)K;KWDGS(0.996)EEDEDNS(0.004)K;KWDGS(0.998)EEDEDNS(0.002)K;KWDGS(1)EEDEDNSK;KWDGS(1)EEDEDNSK;KWDGS(0.995)EEDEDNS(0.005)K;KWDGS(0.708)EEDEDNS(0.292)K;KWDGS(0.991)EEDEDNS(0.009)K 233.84 3.0526e-13 469693400.0 472336.0 415752.0 423939.0 406805.0 384640.0 313184.0 393039.0 384451.0 262315.0 353160.0 True False 446085.4560308204 447638.84154662024 396663.2262898841 351397.4572222329 336318.08447477076 356322.2531987092 411316.09229200374 385569.68876071076 314785.329693483 342963.35318012425 1.3006796554048632 1.3052089600707877 1.1565761257342173 1.0245918520562138 0.9806239685851701 1.0389513920210853 1.1993004164383145 1.1242299947954197 0.917839549837145 1.0 18.38769490211805 -5.446797655677127 2.8182621015744176 1.0504280033252302 1.3055345142823944 0.6672905464253176 0.07356247150953908 0.17416785273242508 2.672101675731162 0.02188355725246629 0.052256963472177426 3.5743933571784427e-06 5.446797655677127 0.2551065109571642 KWDGS(ph)EEDEDNSKK ddPTM_A459_Selumetinib_30min_R1 2 KWDGSEEDEDNSKK 14 2 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KWDGS(0.995)EEDEDNS(0.005)KK;KWDGS(1)EEDEDNSKK 94.188 0.015241 318480000.0 6022.2 6817.0 9226.7 9965.2 6267.6 7843.6 7136.1 7271.0 4542.9 6703.4 True False 6162.505542838654 6018.862470862683 7973.764818635252 8224.964889971596 5700.696686634655 7764.70050541899 6597.818231692933 7078.149460463433 7708.9694997117995 7563.846686645403 0.814731683247767 0.7957409397905278 1.054194399883011 1.0874050242839337 0.7536769216514801 1.0265544539828142 0.87228344320383 0.935787008078904 1.0191863768633258 1.0 12.884904405927289 -5.240437224819438 24.52668640740068 0.961534633303647 0.8052362541991583 0.33113543868524875 0.09245212139589341 767.3882322017838 896165.0325145681 0.023474172250575888 0.0619505167673501 5.7486090622220806e-06 5.240437224819438 -0.15629837910448863 KWDGS(ph)EEDEDNSKK ddPTM_A459_Selumetinib_30min_R2 1 KWDGSEEDEDNSKK 14 2 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KWDGS(1)EEDEDNSKK 129.46 0.0011879000000000002 48989000.0 47771.0 43304.0 41825.0 39476.0 31055.0 27018.0 36671.0 38454.0 19778.0 34299.0 True False 45116.07906246472 46625.27755569377 39134.02503561681 34099.30070010166 27153.593264777508 30739.484255015377 38376.27416220796 38565.89477359762 23734.152643492336 33308.69875049567 1.3544833858690846 1.3997928260406731 1.1748890381085346 1.0237355999863016 0.815210268890298 0.9228665606325417 1.152139699292122 1.1578325248452919 0.7125511813378523 1.0 15.023611373823613 -5.546420080413207 2.365942250315657 0.9727863963985368 1.3793360757208901 0.6207132205689583 0.12867184471839177 0.2053845377591476 2.285247747474711 0.03861956103407008 0.08893340146301144 2.8417110732286003e-06 5.546420080413207 0.4065496793223533 KWDGSEEDEDNS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 KWDGSEEDEDNSK 13 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 KWDGS(0.473)EEDEDNS(0.527)K 79.32600000000002 0.020181 151960000.0 254900.0 281450.0 233780.0 244310.0 225430.0 192470.0 213750.0 219320.0 155650.0 205230.0 True False 240733.67844554756 303036.3099956129 218738.84932041864 211034.55654174308 197109.46803023003 218980.99543129766 223689.79853758984 219958.18488961953 186784.34922436942 199304.47664842178 1.2078688973464853 1.5204691590052777 1.0975109691403448 1.0588550748612309 0.9889866567218969 1.098725924845059 1.1223521031701882 1.103628922884815 0.9371809021322778 1.0 17.604614589861875 -5.388982000559269 6.170073193096221 1.0538749343662308 1.3618245708525094 0.666708415699746 0.0889961839844991 0.12156726272656078 5.525993612243429 0.022203190888469095 0.046875309921961206 4.083363095799437e-06 5.388982000559269 0.3079496364862786 KWPQGAVPQLPPS(ph)APATSEMTTTPERPR ddPTM_A459_Selumetinib_30min_R1 1 KWPQGAVPQLPPSAPATSEMTTTPERPR 28 2 P27708;F8VPD4;H7BZB3 P27708;H7BZB3 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 KWPQGAVPQLPPS(0.245)APAT(0.151)S(0.151)EMT(0.151)T(0.151)T(0.151)PERPR 80.293 2.5733e-05 126630000.0 3339.6 4339.4 3981.2 3942.9 3974.7 3835.0 3788.1 3769.1 1993.1 3031.9 True False 3417.406182269597 3831.3410306676687 3440.574907166228 3254.3465323996497 3615.1890867902794 3796.423381901398 3502.3605671831933 3669.131224237757 3382.145129735541 3421.073898206913 0.9989279050828928 1.1199234932270212 1.005700259491482 0.9512646114149566 1.0567410100919212 1.1097168593438502 1.023760570918648 1.0725086137896227 0.9886208922608262 1.0 11.740233552587009 -8.281177881799808 23.97389394753185 0.9943104186394318 1.0427578930814125 0.13503967621234325 0.0485897770134891 1173.114924510475 1424814.1959952817 0.04766476298509126 0.012385850098136184 5.2338602005452725e-09 8.281177881799808 0.04844747444198072 KWPQGAVPQLPPS(ph)APATSEMTTTPERPR ddPTM_A459_Selumetinib_30min_R2 1 KWPQGAVPQLPPSAPATSEMTTTPERPR 28 2 P27708;F8VPD4;H7BZB3 P27708;H7BZB3 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 KWPQGAVPQLPPS(0.281)APAT(0.173)S(0.137)EMT(0.137)T(0.137)T(0.137)PERPR 80.83 2.4192e-05 16651000.0 67320.0 48619.0 69959.0 81517.0 69225.0 62626.0 60454.0 65894.0 58625.0 63045.0 True False 63578.623903312204 52347.92096527515 65457.914105599986 70414.24397533164 60528.3366206479 71252.1630377745 63265.23078732842 66085.74063066108 70351.63811936181 61224.72703941808 1.0384468331296703 0.8550127292780283 1.069141787491457 1.1500948616724271 0.9886256672353667 1.1637808199928845 1.0333280987369142 1.0793962476649892 1.1490723033206434 1.0 15.901826816329626 -5.393526081345802 7.69008203506262 1.0836269622459322 0.9474688865135348 0.3572300745752135 0.07109528515593523 0.24407049133550013 14.005400464436569 0.017171087155656965 0.03591865005547972 4.040861065884172e-06 5.393526081345802 -0.13615807573239747 KWPQGAVPQLPPSAPAT(ph)SEMTTTPERPR ddPTM_A459_Selumetinib_30min_R2 4 KWPQGAVPQLPPSAPATSEMTTTPERPR 28 2 P27708;F8VPD4;H7BZB3 P27708;H7BZB3 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 KWPQGAVPQLPPS(0.057)APAT(0.266)S(0.21)EMT(0.167)T(0.167)T(0.133)PERPR;KWPQGAVPQLPPS(0.01)APAT(0.198)S(0.198)EMT(0.198)T(0.198)T(0.198)PERPR;KWPQGAVPQLPPS(0.035)APAT(0.263)S(0.199)EMT(0.199)T(0.152)T(0.152)PERPR;KWPQGAVPQLPPS(0.117)APAT(0.177)S(0.177)EMT(0.177)T(0.177)T(0.177)PERPR 78.717 9.9978e-05 36858200.0 148272.0 113487.79999999999 162044.0 180879.0 180668.0 147698.0 153675.0 146005.4 132800.7 142050.2 True False 140031.6358198439 122191.94933920781 151618.26546016693 156242.96816632117 157970.87064758738 168042.05883104814 160821.19200123576 146430.251541505 159364.55076158498 137948.84163525674 1.0150983086185976 0.8857772772191093 1.0990905299593077 1.1326152964693603 1.1451409723705388 1.2181476614016034 1.165803134660997 1.0614822843433038 1.1552438488969148 1.0 17.07377381678159 -5.3913151410649505 5.095371901937915 1.1331107562186087 0.9520229545138712 0.5385507004523596 0.06356007392690881 0.14811224807227055 5.44485896794016 0.016357397157946645 0.03510225381392402 4.061485049671023e-06 5.3913151410649505 -0.18108780170473748 KWPQGAVPQLPPSAPATS(ph)EMTTTPERPR ddPTM_A459_Selumetinib_30min_R1 1 KWPQGAVPQLPPSAPATSEMTTTPERPR 28 2 P27708;F8VPD4;H7BZB3 P27708;H7BZB3 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 KWPQGAVPQLPPS(0.045)APAT(0.035)S(0.277)EMT(0.214)T(0.214)T(0.214)PERPR 87.65899999999998 2.8132e-05 35672000.0 3997.5 5141.5 5848.5 5857.5 4950.9 5010.4 4861.5 4951.0 2432.9 4042.7 True False 4090.6339722190423 4539.530789781498 5054.305823510923 4834.597583892808 4503.091969152387 4959.999925079209 4494.7931409838975 4819.683396885498 4128.453608014446 4561.619924232685 0.8967502861183974 0.9951576118093832 1.1080067843138233 1.0598422630982438 0.987169480129333 1.0873330105233474 0.985350207961478 1.0565727695290665 0.9050411206078065 1.0 12.15533053046433 -9.839005702015537 7.501407505076562 0.9999784433311327 1.0153853744012125 0.0 0.06766502321083341 0.0 0.0 0.06482067842535516 0.01572132375717266 1.4487528321992615e-10 9.839005702015537 0.015406931070079732 KWPQGAVPQLPPSAPATSEMT(ph)TTPERPR ddPTM_A459_Selumetinib_30min_R1 1 KWPQGAVPQLPPSAPATSEMTTTPERPR 28 2 P27708;F8VPD4;H7BZB3 P27708;H7BZB3 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 KWPQGAVPQLPPS(0.003)APAT(0.047)S(0.115)EMT(0.278)T(0.278)T(0.278)PERPR 109.54 8.9615e-10 128850000.0 3276.0 4218.3 3834.7 5202.2 4248.7 3845.9 3585.3 3222.4 2154.3 3194.5 True False 3352.3244260136544 3724.4194749655358 3313.9688024993306 4293.7334273883325 3864.4058351689114 3807.2137377978083 3314.8579344584086 3136.931484169628 3655.6897561533656 3604.5451920650353 0.9300270207163406 1.0332564239073458 0.9193861155617156 1.191199776560011 1.0720924913567258 1.056225830148814 0.9196327852278458 0.8702710930286569 1.0141889091031286 1.0 11.815601521785382 -7.260816924755309 24.982458354830037 0.9402124527886396 1.0373862640063214 0.1959781472551202 0.08065204988675982 84.92075861458719 3408437.2234143848 0.03293518717672453 0.02398804962051788 5.4850813778448063e-08 7.260816924755309 0.09717381121768176 KWS(ph)LNTYK ddPTM_A459_Selumetinib_30min_R2 1 KWSLNTYK 8 1 P53367;P53367-2 P53367 ARFIP1 Arfaptin-1 1 KWS(0.983)LNT(0.016)Y(0.001)K 95.401 0.039357 16471000.0 36967.0 20306.0 31201.0 33680.0 45957.0 18386.0 31036.0 38647.0 17867.0 22844.0 True False 34912.52213062598 21863.404905919044 29193.561629080235 29092.725898759345 40183.47079920722 20918.504608509593 32479.235496667283 38759.45637164475 21440.899245691067 22184.434364159984 1.5737395670104994 0.985529067229247 1.3159479818085347 1.311402644809373 1.8113362792844312 0.942936126525923 1.4640551552280747 1.7471464782650716 0.9664839271417199 1.0 14.43726014882548 -8.312946250850704 24.923156948592524 0.9832409252962483 1.3762496997845628 0.2701892172124635 0.26877560272214923 535.5937453784023 259158.2955136368 0.25399935568739906 0.06558257079964575 4.864674081404649e-09 8.312946250850704 0.3930087744883145 KY(ph)IFS(ph)VR ddPTM_A459_Selumetinib_30min_R1 3 KYIFSVR 7 1 E9PIN0;Q13315 E9PIN0 ATM Serine-protein kinase ATM 2 KY(1)IFS(1)VR;KY(1)IFS(1)VR;KY(1)IFS(1)VR 89.369 0.013063 90608600.0 9105.4 9001.8 10633.7 11187.5 9604.6 8280.3 8576.1 8814.9 4417.1 7967.0 True False 9317.5381039758 7947.865071176711 9189.701946733032 9233.81314038426 8735.865625829854 8197.007699910862 7929.197872342278 8581.10021716946 7495.49608778027 8989.64205515171 1.036474872615888 0.8841136301552758 1.0222544891502854 1.0271613801455668 0.9717701296931591 0.9118280404961607 0.8820371071168823 0.9545541596121588 0.833792496052144 1.0 13.134047957071623 -6.704085156202702 4.382710226697585 0.9111446169459058 0.9880558724956058 0.28578737617057537 0.057012675286268466 0.27133658756870904 10.577460378684062 0.018890045649396853 0.01840948134623989 1.9765820350871624e-07 6.704085156202702 0.07691125554970002 KY(ph)LY(ph)VT(ph)SSFK ddPTM_A459_Selumetinib_30min_R2 1 KYLYVTSSFK 10 1 Q86VD1-2;Q86VD1 Q86VD1-2 MORC1 MORC family CW-type zinc finger protein 1 3 KY(0.999)LY(0.987)VT(0.914)S(0.05)S(0.049)FK 50.95 0.046268 7156300.0 40451.0 40687.0 39938.0 24369.0 21658.0 19685.0 24673.0 18015.0 10800.0 28066.0 True False 38202.89535818301 43807.56207067507 37368.43256120659 21049.900161130237 18937.128415023373 22396.430067361674 25820.343388622 18067.4206674562 12960.301777212931 27255.661655774584 1.4016498972091203 1.6072830160552598 1.3710337702731732 0.7723129391236206 0.69479613645744 0.8217166161738217 0.9473387113004287 0.6628868855079989 0.47550860958339886 1.0 14.734268322991348 -5.7160417344850805 4.063645871470651 0.7569519550619491 1.4997824803971778 0.825570692337321 0.14647703384832278 0.08110238371149553 2.797787364789513 0.04162171581460609 0.07250097712915266 1.9229069340527704e-06 5.7160417344850805 0.7428305253352286 KY(ph)PPMDS(ph)DSR ddPTM_A459_Selumetinib_30min_R2 1 KYPPMDSDSR 10 1 O95803 O95803 NDST3 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3;Heparan sulfate N-deacetylase 3;Heparan sulfate N-sulfotransferase 3 2 KY(1)PPMDS(0.927)DS(0.073)R 54.539 0.041394 1113600.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 KY(ph)RCT(ph)DCDY(ph)T(ph)T(ph)NK ddPTM_A459_Selumetinib_30min_R2 1 KYRCTDCDYTTNK 13 2 E9PEP7;P17010-2;P17010;P17010-3 E9PEP7 ZFX Zinc finger X-chromosomal protein 5 KY(1)RCT(1)DCDY(1)T(1)T(1)NK 49.632 0.032848 3200000.0 4627.4 4170.5 5367.3 7899.9 8206.4 5079.9 5420.8 4466.3 4793.6 5492.0 True False 4370.227632949888 4490.3639397289135 5021.973761474387 6823.919991912381 7175.438665853166 5779.610114259106 5672.877941111424 4479.296193564234 5752.453944374804 5333.43169007033 0.8194025698475309 0.8419277119624459 0.9416027153444548 1.2794614027994418 1.3453699386854894 1.0836569117439832 1.0636449983362621 0.8398525478265135 1.0785652237910164 1.0 12.380848389716233 -5.532658226462785 22.663168040974487 1.1009709414150965 0.8459400503048286 0.40924419384428523 0.13148498611146706 68.50315098161045 158749.36894808768 0.04051556667642129 0.07034096380543865 2.933200656575431e-06 5.532658226462785 -0.255030891110268 KYDLESAS(ph)AILPSSAIEDPDLGSLGK ddPTM_A459_Selumetinib_30min_R1 2 KYDLESASAILPSSAIEDPDLGSLGK 26 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 KY(0.002)DLES(0.017)AS(0.538)AILPS(0.251)S(0.193)AIEDPDLGSLGK;KY(0.043)DLES(0.304)AS(0.653)AILPSSAIEDPDLGSLGK 108.49 1.3507e-08 29063000.0 7818.6 7926.0 6247.1 5992.299999999999 5109.1 7652.3 6655.1 6417.0 3985.5 5656.1 True False 8000.758167652736 6998.020235302571 5398.778132863998 4945.857294402198 4646.982807084868 7575.324809732486 6153.100448948253 6246.800314646385 6763.102410597055 6382.1155300795235 1.2536216447264852 1.0965047878435026 0.8459229713750931 0.7749557761986441 0.7281257735281024 1.1869614039465837 0.9641161179154623 0.9787977489916337 1.0596960175230146 1.0 12.639819009412845 -4.990343149530569 3.705055375616197 0.9379527972806819 1.2403499800070499 0.3744284240790958 0.12776752315680032 0.24889171733163984 7.333571726500639 0.03550841969499002 0.15594872686748817 1.0224847761122308e-05 4.990343149530569 0.30239718272636795 KYEDICPSTHNMDVPNIK ddPTM_A459_Selumetinib_30min_R1 1 KYEDICPSTHNMDVPNIK 18 1 P63241;P63241-2;I3L397;I3L504;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 P63241 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 110.12 0.00094464 18232000.0 4666.2 4880.5 4486.3 5343.4 6263.1 4579.5 5623.4 4746.0 1910.8 2975.8 False True 4774.9133811553465 4309.0887911171085 3877.0851014819273 4410.2754980406025 5696.603710840112 4533.434387853312 5199.222410574688 4620.120662819343 3242.4880406897155 3357.772916746634 1.422047738053051 1.2833175137085238 1.1546597097574 1.3134525792511735 1.69654227730194 1.350131322235389 1.548413945637588 1.3759479206520628 0.9656662678164017 1.0 11.713288950028959 -10.301501277486153 9.375235191146333 1.0000004155755884 1.354500090934848 0.22995445385596713 0.1890811989430519 0.0 0.0 0.1881993253486414 0.04564504100484894 4.9945771104095524e-11 10.301501277486153 0.3544996753592595 KYEEIDNAPEER ddPTM_A459_Selumetinib_30min_R1 1 KYEEIDNAPEER 12 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 140.45 0.0050711 0.0 2933.0 4325.1 4222.9 4592.3 4037.1 3920.4 3466.0 3475.6 1736.6 2823.2 False True 3001.3331933754725 3818.7152813155617 3649.453374729295 3790.341013147408 3671.9450178078946 3880.9643354383966 3204.556829507392 3383.4157976601177 2946.8833637543194 3185.585220296761 0.9421606975863217 1.1987484299540478 1.145614737121778 1.1898413481445993 1.1526751801874024 1.2182892834607189 1.0059554549317202 1.062101800354576 0.9250681303323587 1.0 11.63734271738323 -7.282744354096522 23.301793587121463 1.0034564323399142 1.1467667522578078 0.4434585560212765 0.07821448903784058 324.85194041730557 355296.17704876384 0.0318656426212278 0.02151652802347328 5.215016008355855e-08 7.282744354096522 0.14331031991789356 KYEQGFITDPVVLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 KYEQGFITDPVVLSPK 16 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 KYEQGFITDPVVLS(1)PK;KYEQGFITDPVVLS(1)PK 115.76 0.0010137 42119000.0 11979.0 15285.599999999999 13685.5 14218.8 10582.9 12316.5 11838.8 12492.9 8279.099999999999 11860.3 True False 12258.087392923562 13495.954845917357 11827.084269070492 11735.753499932578 9625.67856356275 12192.607192487249 10945.789784527436 12161.547709341723 14049.028018460434 13382.685034105156 0.9159662176674107 1.0084639077676518 0.8837601900462959 0.8769356425877581 0.7192636260236381 0.9110733131217653 0.8179068517739598 0.9087524423050067 1.0497914269563347 1.0 13.70807997959189 -8.156356052445462 4.605157735250575 1.0236556096106937 0.8762255104190405 0.40623838525503975 0.0706279026707425 0.23345134114780616 7.76245255196906 0.05563808709359682 0.01950317177707681 6.976601990782278e-09 8.156356052445462 -0.14743009919165317 KYES(ph)DEDS(ph)LGSSGR ddPTM_A459_Selumetinib_30min_R2 1 KYESDEDSLGSSGR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 2 KY(0.039)ES(0.961)DEDS(0.996)LGS(0.004)SGR 115.58 0.013604 0.0 18083.0 16037.0 16934.0 17132.0 15773.0 14620.0 16046.0 16475.0 11589.0 18293.0 True False 17078.019251984457 17266.986332917535 15844.484876345135 14798.592045651572 13791.454727590912 16633.772292853835 16792.170794545797 16522.939522416928 13907.123823714872 17764.833559078048 0.9613385453452435 0.9719756886826498 0.891901678878855 0.8330273400219564 0.7763345871902813 0.9363314459174189 0.9452478537838477 0.9300925599707351 0.7828457146792778 1.0 14.1167365514937 -5.29470755081843 5.540980419545221 0.8820648701672784 0.9670538295957798 0.17653635561557268 0.06833057520778442 0.2875880424837807 26.04467890880519 0.01836884250140679 0.04108668291894202 5.073322252786233e-06 5.29470755081843 0.08498895942850138 KYES(ph)DEDSLGSSGR ddPTM_A459_Selumetinib_30min_R1 2 KYESDEDSLGSSGR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 KYES(0.938)DEDS(0.062)LGSSGR;KYES(0.976)DEDS(0.024)LGSSGR 228.49 6.072399999999998e-13 32830000.0 4036.6 3966.2 4945.3 5044.2 4751.6 3980.9 4064.3 3989.5 2029.8200000000002 3282.0 True False 4130.644926143685 3501.835460163643 4273.755422588452 4163.325161361006 4321.818618963115 3940.8557603680024 3757.7265788132977 3883.68550027766 3444.45628781285 3703.2766693872113 1.1154027351748448 0.9456046017601755 1.1540470248731483 1.1242274161627575 1.1670255843126771 1.0641537514452313 1.0147031708098375 1.0487160012595822 0.9301104387598487 1.0 11.854586621004582 -7.517999741516163 1.516397416972896 0.9818850561428047 1.0963692096707718 0.37717936891455983 0.06269877056020261 0.484982141728271 2.1466703971772496 0.044603675048230006 0.02132892804072617 3.033892989909289e-08 7.517999741516163 0.11448415352796704 KYES(ph)DEDSLGSSGR ddPTM_A459_Selumetinib_30min_R2 1 KYESDEDSLGSSGR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 KYES(0.94)DEDS(0.06)LGSSGR 145.94 0.00091122 23884000.0 27056.0 22583.0 30038.0 24720.0 26376.0 19334.0 19343.0 20433.0 24106.0 24681.0 True False 25552.33583374946 24315.04348421006 28105.387782901576 21353.093355621455 23062.411075568238 21997.083003422435 20242.48782742737 20492.456647134757 28927.87357791619 23968.395401060774 1.066084542005619 1.0144627154779808 1.172601974918092 0.8908853929652891 0.9622008770160543 0.9177536766791199 0.8445491443507934 0.8549782454868805 1.2069174049354978 1.0 14.548845708460599 -5.7731603610133435 24.990306501674137 0.9421390038155524 1.0773910576570682 0.24395967312336442 0.10361144095520947 287.2737936660444 612496.425148729 0.028917281547203834 0.04329106353286433 1.6859303892809257e-06 5.7731603610133435 0.13525205384151584 KYESDEDS(ph)LGSSGR ddPTM_A459_Selumetinib_30min_R1 1 KYESDEDSLGSSGR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 KYES(0.285)DEDS(0.715)LGSSGR 201.72 9.9303e-05 16581000.0 3297.3 3441.4 4009.7 4149.7 3749.4 3245.2 3325.7 3280.9 1716.6 3072.4 True False 3374.1206745710692 3038.4792881365433 3465.204763705522 3425.0327945164295 3410.267432010335 3212.5562344058476 3074.8397714635703 3193.879874134849 2912.9448244965256 3466.7724677103197 0.9732743368645581 0.8764576609619122 0.9995477914921157 0.9879600771084184 0.9837009679099868 0.9266706322170682 0.88694594182421 0.9212833850166964 0.8402469015857918 1.0 11.759377436899992 -6.9558107893499415 5.58399754803871 0.9056081935952749 0.9623427782028245 0.20183712732741055 0.04876403946833873 0.28582758294407873 21.25303525703277 0.01727832146406315 0.015020530736788731 1.1071060158103284e-07 6.9558107893499415 0.056734584607549654 KYESDEDS(ph)LGSSGR ddPTM_A459_Selumetinib_30min_R2 1 KYESDEDSLGSSGR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 KYES(0.311)DEDS(0.689)LGSSGR 135.61 0.0010808 20036000.0 43168.0 31139.0 42576.0 45274.0 43157.0 33840.0 37061.0 38847.0 29671.0 40754.0 True False 40768.895375195774 33527.26117233395 39836.70651324379 39107.603097993764 37735.231831524805 38501.1528310652 38784.4099349783 38960.038338532926 35606.02907700787 39577.326128391556 1.0301073711482853 0.8471330545062398 1.0065537622226117 0.9881315117430122 0.9534558173310933 0.9728083374345408 0.9799653925371061 0.9844029940816086 0.8996572674338704 1.0 15.272386525749504 KYGGPPPDSVYSGQQPS(ph)VGTEIFVGK ddPTM_A459_Selumetinib_30min_R1 2 KYGGPPPDSVYSGQQPSVGTEIFVGK 26 1 O60506-2;O60506;O60506-4;O60506-3;B7Z645;F6UXX1 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 KYGGPPPDSVYS(0.008)GQQPS(0.977)VGT(0.014)EIFVGK;KYGGPPPDSVYSGQQPS(0.782)VGT(0.218)EIFVGK 102.6 4.6516000000000007e-07 26557000.0 5134.9 6429.8 7406.9 8783.7 6867.200000000001 6131.700000000001 6131.4 5371.799999999999 2971.5 4332.6 True False 5254.533179223905 5676.996026867078 6401.083663189378 7249.7916854697905 6246.062972502636 6070.020665138157 5668.90356158154 5229.322413934463 5042.4184702268585 4888.731413097813 1.0748254987267334 1.1612411374569196 1.3093547430402281 1.482959703215902 1.277644943996776 1.2416351303071083 1.159585807146922 1.0696685851720436 1.031437001574128 1.0 12.255244430520316 -7.616040191536684 1.605584084529981 1.0173535290207174 1.2695305991204346 0.5127818954474624 0.09879197532604217 0.36292794805871814 1.804306853659596 0.07886836777834681 0.03505361105255245 2.4208050043423038e-08 7.616040191536684 0.25217707009971724 KYGGSVGSQPPPVAPEPGPVPS(ph)SPSQEPPTKR ddPTM_A459_Selumetinib_30min_R1 2 KYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 32 2 E9PS08;A0A087WTZ5;E9PJ81;E9PRQ7;Q04323;Q04323-2 E9PS08 UBXN1 UBX domain-containing protein 1 1 KYGGSVGSQPPPVAPEPGPVPS(0.463)S(0.463)PS(0.068)QEPPT(0.005)KR;KYGGSVGSQPPPVAPEPGPVPS(0.478)S(0.478)PS(0.038)QEPPT(0.006)KR 117.05 6.4579e-17 59958000.0 3946.3 5097.9 5884.700000000001 6672.5 5051.1 3979.7 4668.5 4290.6 2693.23 3757.5 True False 4038.241111836899 4501.035498050588 5085.590062343291 5507.273133337562 4594.2288968441335 3939.6678312784875 4316.351286369085 4176.79935016702 4570.21460426353 4239.811726149435 0.9524576496948365 1.061612116002706 1.1994848806557703 1.2989428514881782 1.083592667218876 0.9292082020954415 1.018052584681434 0.9851379306317352 1.077928667463299 1.0 12.049784486294596 -6.530842748717279 23.399356388883685 1.0026095744566108 1.1363203048736148 0.3043522537304618 0.09024074898439237 110.16093515563846 323662.60054443096 0.032100258395336104 0.032173343825552314 2.9454879561521466e-07 6.530842748717279 0.133710730417004 KYGGSVGSQPPPVAPEPGPVPS(ph)SPSQEPPTKR ddPTM_A459_Selumetinib_30min_R2 2 KYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 32 2 E9PS08;A0A087WTZ5;E9PJ81;E9PRQ7;Q04323;Q04323-2 E9PS08 UBXN1 UBX domain-containing protein 1 1 KYGGSVGSQPPPVAPEPGPVPS(0.419)S(0.419)PS(0.13)QEPPT(0.032)KR;KYGGSVGSQPPPVAPEPGPVPS(0.477)S(0.477)PS(0.043)QEPPT(0.003)KR 116.98 6.519199999999999e-17 45671000.0 127596.0 114785.0 126042.0 147073.0 160189.0 106817.0 93771.0 94654.0 84311.0 132418.0 True False 120504.72512725812 123588.64040805271 117932.59494415324 127041.40368492377 140064.62571217015 121530.0721618173 98131.53730371139 94929.42746918675 101175.55584616643 128594.74827671752 0.937089008238106 0.9610706662927448 0.9170871790998739 0.9879206218557917 1.0891939802298232 0.9450624834250769 0.7631068812588392 0.7382060989373546 0.7867782876206663 1.0 16.972472199607758 -7.17224386862711 5.250633479717096 0.8007162721317905 0.9779425348473828 0.45564304958278845 0.07984438209124181 0.17999374466609017 8.070499752987496 0.030784236160865903 0.023606573393088408 6.725988669494602e-08 7.17224386862711 0.17722626271559228 KYGTDLS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 KYGTDLSR 8 1 Q5TC02;Q5TC01;P05023-2;P05023-3;P05023-4;P05023 Q5TC02 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 KYGTDLS(1)R 84.743 0.024914 12219000.0 1852.9 2480.0 2562.3 2585.5 2386.3 2308.1 2061.4 1728.7 1172.0 1980.8 True False 1896.0689648842176 2189.6404470792804 2214.353733706427 2133.9909608459 2170.4595863354825 2284.8826095871245 1905.9069383573378 1682.849260391025 1988.7984005067751 2235.054974625894 0.8483321378712771 0.9796808006683527 0.9907379276328844 0.9547823141142603 0.9710989711556319 1.0222936954692001 0.8527338074430812 0.7529341691797546 0.8898207977366026 1.0 11.12609460181777 -7.283178755995583 23.48980806159949 0.8532833313241475 0.9635035210775758 0.24582632807139726 0.07126635006404086 419.64174117175014 453427.5996281497 0.028874973226821705 0.019493486793394757 5.209802310408756e-08 7.283178755995583 0.11022018975342829 KYILGNPLTPGVT(ph)QGPQIDKEQYDK ddPTM_A459_Selumetinib_30min_R1 1 KYILGNPLTPGVTQGPQIDKEQYDK 25 2 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 KYILGNPLT(0.051)PGVT(0.949)QGPQIDKEQYDK 109.32 2.8585e-07 16845000.0 3383.2 5167.0 5488.9 6253.1 4669.5 4749.1 5352.2 5576.6 2233.0 3603.7 True False 3462.021977438767 4562.045237926872 4743.537528369519 5161.113470224519 4247.144549467186 4701.328365837793 4948.479244919061 5428.690452650305 3789.2379081327863 4066.2699980105667 0.85139992650084 1.1219238368723337 1.166557442248131 1.2692500676909324 1.0444816875281555 1.1561771274750399 1.216957862448907 1.3350541049429345 0.9318707095167514 1.0 11.989490297153758 -4.7597463219314236 3.900769931721962 1.15605984765979 0.8150550356194364 0.34711528165306793 0.11650969270441097 0.2731542900553075 7.500823565605909 0.027965007641918487 0.27523524045309605 1.7388162013882867e-05 4.7597463219314236 -0.3410048120403537 KYILGNPLTPGVTQGPQIDKEQYDK ddPTM_A459_Selumetinib_30min_R1 2 KYILGNPLTPGVTQGPQIDKEQYDK 25 2 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 150.13 3.6467e-10 34823000.0 4912.9 5913.7 7199.2 8019.6 5723.1 5586.7 5564.9 5577.0 3276.3999999999996 4767.1 False True 5027.361011160711 5221.321254795456 6221.58818237494 6619.127406536369 5205.44661549537 5530.502870317741 5145.135112673309 5429.0798433509235 5559.8115012119415 5379.003720486218 0.9346267956673358 0.970685562999293 1.156643219761997 1.2305489548793347 0.9677343400358979 1.0281649089132492 0.9565219471921522 1.0093095534911023 1.0336136188263092 1.0 12.393123271456265 KYLES(ph)LMGKRVS(ph)NIS(ph)EDPVPVK ddPTM_A459_Selumetinib_30min_R2 1 KYLESLMGKRVSNISEDPVPVK 22 3 P01282-2 P01282-2 3 KY(0.512)LES(0.55)LMGKRVS(0.969)NIS(0.969)EDPVPVK 47.397 0.033821 10175000.0 19371.0 15643.0 17268.0 17700.0 16727.0 13176.0 13880.0 19270.0 11159.0 15087.0 True False 18294.437368256982 16842.767799827212 16156.995679976842 15289.22946579692 14625.604718722701 14990.874400180712 14525.447502698235 19326.072509679765 13391.111808511021 14651.399109266402 1.2486478070675524 1.1495671965672454 1.102761283033933 1.043533750720579 0.9982394588836648 1.0231701620017712 0.9914034417034951 1.3190598635359558 0.913981778029765 1.0 13.838750818369073 -4.947103366547522 1.3945507332161338 1.0508568857768774 1.2912922200379398 0.29668297726792825 0.1006352927910818 1.237861987177655 2.733921072929269 0.029270487422380205 0.38608674004086685 1.1295270436387788e-05 4.947103366547522 0.24043533426106234 KYS(ph)ASSGGLCEEATAAK ddPTM_A459_Selumetinib_30min_R1 2 KYSASSGGLCEEATAAK 17 1 Q9UHV7;J3QRB7 Q9UHV7 MED13 Mediator of RNA polymerase II transcription subunit 13 1 KYS(0.867)AS(0.131)S(0.002)GGLCEEATAAK;KYS(0.579)AS(0.21)S(0.21)GGLCEEATAAK 164.59 2.0793e-05 0.0 1520.6599999999999 1546.57 2115.1 1848.79 1912.3 1631.67 1742.1100000000001 1680.52 1017.21 1227.5500000000002 True False 1556.088419310721 1365.4968654191123 1827.8810374126638 1525.9335325864588 1739.3328026439867 1615.2568812378238 1610.7012401191919 1635.9471505017198 1726.131075921072 1385.1179998495638 1.123433829810692 0.9858343228283926 1.3196572693526385 1.101663203244914 1.255728972428987 1.1661511015041715 1.1628621101553285 1.1810886514213217 1.2461978518137409 1.0 10.435793171078215 -5.241871163041221 24.997803218259318 1.184555064092337 1.054634084375817 0.2388462022319665 0.08850871951667882 1031.7460674734386 1318019.8438474482 0.02035979485677557 0.05370770881349894 5.729659807528022e-06 5.241871163041221 -0.12992097971651995 KYS(ph)ASSGGLCEEATAAK ddPTM_A459_Selumetinib_30min_R2 2 KYSASSGGLCEEATAAK 17 1 Q9UHV7;J3QRB7 Q9UHV7 MED13 Mediator of RNA polymerase II transcription subunit 13 1 KY(0.013)S(0.945)AS(0.035)S(0.007)GGLCEEATAAK;KY(0.001)S(0.737)AS(0.187)S(0.075)GGLCEEATAAK 124.31 0.00067557 29154000.0 128834.0 116855.0 125347.0 121836.0 109714.0 92662.0 102087.0 95412.0 82431.0 113402.0 True False 121673.92204336482 125817.40275195357 117282.31048749476 105241.72662117709 95930.7464643954 105425.34939811369 106834.24778155275 95689.63312369322 98919.50331457774 110127.78960621924 1.1048430416921173 1.1424673390961102 1.0649656268127938 0.9556327880318572 0.871085734194904 0.9573001489912769 0.9700934538281109 0.868896338207167 0.8982247230084373 1.0 16.748819038418695 -5.699725093882285 2.7192673754445393 0.9236732420207874 1.1217001308741235 0.7971459302364722 0.04068250644768691 0.10913190160289467 1.6335653606574208 0.01180746864253413 0.022229134479384148 1.9965257053140055e-06 5.699725093882285 0.19802688885333608 KYSDVEVPASVTGY(ph)SFASDGDSGTCSPLR ddPTM_A459_Selumetinib_30min_R1 1 KYSDVEVPASVTGYSFASDGDSGTCSPLR 29 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 KYSDVEVPASVT(0.039)GY(0.493)S(0.122)FAS(0.008)DGDS(0.061)GT(0.061)CS(0.214)PLR 134.0 1.4993e-13 25083000.0 2584.5 2715.1 3023.9 3278.0 3387.2 2377.8 2884.1 2542.8 1499.8 2219.2 True False 2644.7138214384277 2397.2148297842546 2613.2709890937326 2705.558835680858 3080.8283580587304 2353.88149086966 2666.5500149977674 2475.356683821541 2545.051058942032 2504.0559368385434 1.0561720217709951 0.957332779399018 1.0436152606051912 1.0804706060587124 1.2303352783518016 0.9400275194497117 1.06489235155201 0.9885388930036298 1.0163714881526353 1.0 11.29005107492711 -9.729209006404432 8.774427750797951 0.999999999904706 1.042308273042747 0.026257998224387458 0.0766554113222531 0.0 0.0 0.07569303634640863 0.01835825788117409 1.8654817023164328e-10 9.729209006404432 0.042308273138041086 KYTELPHGAISEDQAVGPADIPCDSTGQT(ph)ST ddPTM_A459_Selumetinib_30min_R1 1 KYTELPHGAISEDQAVGPADIPCDSTGQTST 31 1 Q9H773;H3BPN2;H3BSA6 Q9H773 DCTPP1 dCTP pyrophosphatase 1 1 KYTELPHGAISEDQAVGPADIPCDS(0.06)T(0.06)GQT(0.306)S(0.306)T(0.268) 89.181 1.0042e-06 7217500.0 1432.6 1760.1 1992.4 2137.7 1825.3 1558.5 1709.3 1700.8 849.25 1253.7 True False 1465.9767926456534 1554.0266737517095 1721.8430234698083 1764.3908245988318 1660.2019372828893 1542.82290500478 1580.366124834675 1655.6892590229959 1441.1152232341103 1414.6246070721352 1.036300927692614 1.0985435047451184 1.217173103635972 1.2472502003557056 1.173598938533261 1.0906235458451259 1.1171628974456884 1.1704089203211268 1.0187262514942412 1.0 10.466203546647073 -8.292868116168666 7.590210723244012 1.0079090347676862 1.1465873463955536 0.45186129804302244 0.05920651231362468 0.27211076909673143 54.58846753690986 0.06004787542987553 0.01630282211563156 5.094855649568116e-09 8.292868116168666 0.13867831162786737 KYTLENKEEGS(ph)LSDTEADAVSGQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R2 1 KYTLENKEEGSLSDTEADAVSGQLPDPTTNPSAGK 35 2 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 KY(0.061)T(0.065)LENKEEGS(0.272)LS(0.272)DT(0.272)EADAVS(0.057)GQLPDPTTNPSAGK 49.62600000000001 0.0039501 10202000.0 59420.0 71465.0 63723.0 68012.0 62948.0 46841.0 44025.0 45955.0 34819.0 62150.0 True False 56117.67427710645 76946.13570380703 59623.13155635649 58748.64827275597 55039.90947773994 53292.922569737784 46072.249733882534 46088.721441740214 41783.77292414603 60355.56801490733 0.9297845438758169 1.274880483020257 0.9878646414466693 0.9733757829641424 0.9119276197375117 0.8829827027155949 0.7633471318255686 0.7636200429818949 0.6922935911037368 1.0 15.881199250396342 -6.276033531613664 1.0074854246216631 0.7895951245107712 1.098144235792311 0.4756822561582509 0.11267373683535242 0.41281276903011094 0.8845396663371574 0.049912011440794796 0.0762939060220026 5.296225504769525e-07 6.276033531613664 0.30854911128153983 KYTLENKEEGSLS(ph)DTEADAVSGQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R1 2 KYTLENKEEGSLSDTEADAVSGQLPDPTTNPSAGK 35 2 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 KYTLENKEEGS(0.013)LS(0.485)DT(0.485)EADAVS(0.018)GQLPDPTTNPSAGK;KYTLENKEEGS(0.187)LS(0.601)DT(0.187)EADAVS(0.025)GQLPDPTTNPSAGK 94.349 2.795e-11 230200000.0 6845.0 6727.799999999999 7984.5 9253.0 7343.200000000001 7344.200000000001 7866.2 7353.0 3836.7 5553.0 True False 7004.475181948555 5940.106048330633 6900.248755719067 7637.137250321834 6679.0088565472615 7270.3240160000705 7272.8462008860515 7157.974554089892 6510.599678519064 6265.781640800477 1.1178932786833768 0.9480231500010846 1.10125905294675 1.2188642516029589 1.0659498270823866 1.1603219570657204 1.1607244902260778 1.1423913191420174 1.0390722262206555 1.0 12.613278778082599 -5.502365331954379 24.37045879881118 1.1235185792697984 1.030878908816326 0.14690940146635756 0.07233568310263859 779.3399705367143 925873.6755704879 0.01784627673367572 0.03641616235892493 3.145101516723574e-06 5.502365331954379 -0.09263967045347243 KYTLENKEEGSLS(ph)DTEADAVSGQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R2 1 KYTLENKEEGSLSDTEADAVSGQLPDPTTNPSAGK 35 2 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 KY(0.033)T(0.035)LENKEEGS(0.164)LS(0.256)DT(0.256)EADAVS(0.256)GQLPDPTTNPSAGK 47.128 0.006075 5978500.0 10430.0 10279.0 12363.0 14520.0 13582.0 9100.4 7585.6 8438.5 6072.3 13178.0 True False 9850.342354598119 11067.366247805663 11567.578039816643 12542.350951602893 11875.707735379423 10353.897494793911 7938.345430581247 8463.054637931124 7286.929674237969 12797.516899444063 0.7697073136919262 0.8648057537073025 0.9038923824604717 0.9800612923705337 0.9279696857360912 0.8090551922024573 0.6203035708377221 0.6613044315103633 0.5694018403331447 1.0 13.643576290995215 -7.037059326043815 4.434712047306509 0.685794697528799 0.8926596736123845 0.31687440537587674 0.11930464049749494 0.2146947026834242 9.618619373710525 0.044471936965453776 0.035457853542044254 9.182071578212182e-08 7.037059326043815 0.20686497608358556 KYTLENKEEGSLSDTEADAVS(ph)GQLPDPTTNPSAGK ddPTM_A459_Selumetinib_30min_R2 1 KYTLENKEEGSLSDTEADAVSGQLPDPTTNPSAGK 35 2 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 KY(0.111)T(0.117)LENKEEGS(0.049)LS(0.229)DT(0.229)EADAVS(0.264)GQLPDPTTNPSAGK 49.62600000000001 0.0039501 8170900.0 42682.0 45734.0 43392.0 41778.0 42332.0 35390.0 28765.0 31463.0 18823.0 37964.0 True False 40309.9053095836 49241.65074201227 40600.20596163743 36087.76432893014 37013.875707118365 40264.65126156614 30102.629496766152 31554.55212101994 22588.12595856286 36867.880677682086 1.093361065746997 1.335624663986195 1.1012351460227738 0.9788402171643084 1.0039599517724558 1.0921336003438973 0.8165001335427651 0.8558819097003707 0.6126776354746246 1.0 15.170076866128278 -6.534277017127792 0.65617123421215 0.7981522925229539 1.212939415608285 0.5367996357821714 0.12619661142191535 0.5968775544890358 0.5695080659537453 0.09097871385528275 0.12353282591511737 2.922287785873445e-07 6.534277017127792 0.41478712308533117 KYVIS(ph)DEEEEDDD ddPTM_A459_Selumetinib_30min_R2 1 KYVISDEEEEDDD 13 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 KYVIS(1)DEEEEDDD 86.738 0.046811 30053000.0 90110.0 89430.0 94562.0 97515.0 90490.0 77544.0 73862.0 77425.0 74264.0 78802.0 True False 85102.04693891051 96288.99343722734 88477.98387132102 84233.28877724205 79121.83720913589 88224.98212565378 77296.72935477644 77650.29393160123 89118.87510953161 76526.78150781558 1.1120557439125955 1.258239162029746 1.15617019464336 1.1007034023590736 1.0339104252157172 1.1528641396821775 1.010061155477736 1.0146812972092771 1.164544926019527 1.0 16.22367710496097 -5.78293898278323 2.8189651464152856 1.0654942315590585 1.1888444638844187 0.39177194147016015 0.06289427287610459 0.2499233388116467 4.056076652809823 0.017728071444974156 0.030929432074504878 1.6483939702148204e-06 5.78293898278323 0.12335023232536013 KYY(ph)GLDT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 KYYGLDTK 8 1 Q32MZ4-4 Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 2 KYY(1)GLDT(1)K 93.374 0.017934000000000002 9339400.0 9988.7 11121.0 11954.0 13228.0 11454.0 10385.0 10853.0 9841.1 5091.6 8370.5 True False 10221.417275373198 9818.94814998736 10330.712458621796 10917.978120313122 10417.987722367945 10280.536328825568 10034.349472199568 9580.08205960208 8640.073324249395 9444.935210574542 1.082211476043722 1.0395993123376932 1.0937833058987572 1.1559611449837541 1.103023736012924 1.0884708152699119 1.0624053260804922 1.0143089228263025 0.9147837578150855 1.0 13.205325184853985 -7.829756259028899 2.2040620744592823 0.9578901096378709 1.0936487869501255 0.7199360799413028 0.03367694988094376 0.17289132620980815 1.637516393190382 0.02560373764971646 0.010153600624301219 1.4799387475597227e-08 7.829756259028899 0.13575867731225455 LAAAEETAVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 LAAAEETAVSPR 12 0 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 1 LAAAEET(0.015)AVS(0.985)PR;LAAAEETAVS(1)PR;LAAAEETAVS(1)PR;LAAAEETAVS(1)PR 185.2 0.00010451 631729000.0 8954.1 10461.6 9515.300000000001 8259.3 8950.3 8366.7 10618.0 9073.2 5529.9400000000005 7740.1 True False 9162.713108354355 9236.751008534111 8223.174523801576 6816.968301262637 8140.746945303806 8282.538594355787 9817.07571139916 8832.549262092814 9383.904289162483 8733.617229958545 1.049131518716426 1.0576088652992128 0.9415542618004805 0.7805435161365544 0.9321162962556863 0.9483514535013691 1.1240560987404022 1.011327727049327 1.074457929868198 1.0 13.092363587873045 -7.228713302684696 21.80383256795772 1.0534043771768486 0.9472608376482249 0.2861910074499936 0.07789062393522175 192.30315901295467 128121.98645835705 0.032869701469964235 0.02545588031752461 5.9059082707348856e-08 7.228713302684696 -0.10614353952862376 LAAAEETAVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 LAAAEETAVSPR 12 0 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 1 LAAAEETAVS(1)PR;LAAAEETAVS(1)PR;LAAAEETAVS(1)PR;LAAAEETAVS(1)PR;LAAAEETAVS(1)PR;LAAAEETAVS(1)PR 179.59 0.00010389 632221000.0 202477.0 177689.0 265213.0 254127.0 346550.0 248266.0 177457.0 228948.0 301436.0 205101.0 True False 191224.13891965136 191317.17493981283 248149.48432208173 219514.46420647277 303013.2908036913 282462.3879656396 185709.10212437462 229614.20077561852 361731.6228255509 199179.20121360422 0.9600607782063466 0.9605278752706716 1.2458604252356684 1.1020953135114773 1.5213099006192574 1.418131944724091 0.9323719594859508 1.1528020966876713 1.8161114243932621 1.0 17.603707479912075 -5.328651304289023 1.5654698895210484 1.2909878414773204 0.9209412297238881 0.20280331834051235 0.2477066697837997 0.8077623705347948 3.3950445312049102 0.07491823789335288 0.3295045730365875 4.6918994428554866e-06 5.328651304289023 -0.37004661175343223 LAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKK ddPTM_A459_Selumetinib_30min_R2 1 LAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKK 37 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 83.22 1.9632000000000005e-07 16476000.0 13435.0 13860.0 12243.0 10717.0 10932.0 8237.5 8149.3 8022.1 7699.9 11079.0 False True 12688.336484566235 14923.017433075827 11455.298709170516 9257.326112143819 9558.62442668001 9372.140852420205 8528.258597531601 8045.44298286985 9240.095153181655 10759.12048330102 1.1793098240938473 1.3870109044914494 1.064705867635744 0.8604166229490504 0.8884206140748891 0.8710880101181585 0.7926538800981096 0.7477788723861765 0.8588151018034412 1.0 13.393272527495903 -5.558075684574561 2.933681406425259 0.8471671807015388 1.2820901900055164 0.8196889793161102 0.079324462525679 0.09237647016257855 1.6086714161495903 0.021783569885429645 0.045437447671422944 2.766459492025556e-06 5.558075684574561 0.43492300930397754 LAAFADALEFADEEKES(ph)PVEFTGHK ddPTM_A459_Selumetinib_30min_R1 1 LAAFADALEFADEEKESPVEFTGHK 25 1 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 1 LAAFADALEFADEEKES(0.999)PVEFT(0.001)GHK 102.43 8.7229e-07 17445000.0 1213.3 1354.9 1519.5 1525.0 1328.7 1315.8 945.15 1497.3 669.68 1035.1 True False 1241.5675293291715 1196.267678124079 1313.1602460160477 1258.6873777953956 1208.5193196010384 1302.5642466508116 873.8565745553695 1457.586740084155 1136.398048508001 1167.965167727818 1.063017599869473 1.0242323240266842 1.1243145620264472 1.0776754415065908 1.0347220559257904 1.1152423742095368 0.7481871880266661 1.247971069993271 0.9729725508156821 1.0 10.18978153396934 LAAFADALEFADEEKESPVEFTGHK ddPTM_A459_Selumetinib_30min_R1 1 LAAFADALEFADEEKESPVEFTGHK 25 1 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 0 150.13 4.5793e-10 2303600.0 531.04 598.61 705.44 680.93 625.7 518.12 486.24 527.49 268.9 523.53 False True 543.4121987760352 528.5244629137608 609.6451227045477 562.0183581391603 569.1055454763072 512.9081832153204 449.5625253259302 513.4992516710021 456.30366032105104 590.7301751140417 0.9198991716838036 0.8946969110080216 1.032019606221833 0.9513960549427859 0.9633933891500297 0.8682613565767187 0.7610285444435629 0.8692619292249122 0.7724400742402581 1.0 9.206355497986404 -6.86107321122079 4.511162684760897 0.8368370643552373 0.9533905294533322 0.3244672680585632 0.0697147400404024 0.22175979898738293 7.867963494521794 0.024010123606674733 0.02123880830733405 1.3769773252847008e-07 6.86107321122079 0.11655346509809494 LAAGRPFNT(ph)YPR ddPTM_A459_Selumetinib_30min_R2 1 LAAGRPFNTYPR 12 1 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 LAAGRPFNT(0.991)Y(0.009)PR 98.253 0.021393 23505000.0 30184.0 31294.0 29610.0 30337.0 33589.0 20596.0 27341.0 23729.0 21846.0 31390.0 True False 28506.494116125567 33694.1491739304 27704.924836930422 26205.048265756006 29369.249530530073 23432.912048127055 28612.4106751637 23798.04746145257 26215.810428240165 30483.689138985374 0.9351392472923762 1.1053173065867277 0.9088442252056295 0.8596416315058979 0.9634414455752321 0.7687032872330032 0.9386137794776123 0.7806813457829622 0.8599946780953409 1.0 14.89574988803861 -5.444345689426323 6.396488712850158 0.8742281327463013 1.019322904361133 0.3197752487944918 0.07921104754091124 0.23589610166357347 15.645336588205046 0.019440947348177282 0.040731024253978836 3.5946309605993914e-06 5.444345689426323 0.14509477161483164 LAALALASSENSSST(ph)PEECEEMSEKPK ddPTM_A459_Selumetinib_30min_R1 2 LAALALASSENSSSTPEECEEMSEKPK 27 1 O00567 O00567 NOP56 Nucleolar protein 56 1 LAALALASSENSS(0.003)S(0.009)T(0.987)PEECEEMSEKPK;LAALALASSENS(0.003)S(0.059)S(0.214)T(0.724)PEECEEMSEKPK 162.44 3.1663e-17 53094000.0 4963.7 6879.9 7278.200000000001 8429.9 5784.9 6162.2 5749.0 5159.3 2844.67 5184.7 True False 5079.344552321119 6074.398109621259 6289.86041629088 6957.776213821255 5261.656816407049 6100.21386282994 5315.348301453548 5022.458604231742 4827.197223523554 5850.206748254679 0.8682333412979747 1.0383219552767882 1.075151817184472 1.1893214228534748 0.8993967295218728 1.0427347485881326 0.9085744367990587 0.8585095912601921 0.8251327570540435 1.0 12.514271895582251 -7.3468193185910735 4.030391170379099 0.8815838913854486 1.0248902798600228 0.27917955559744256 0.09398565858901414 0.2880119460451259 8.660343169811194 0.04201945933491047 0.02764633343773906 4.499670176791888e-08 7.3468193185910735 0.14330638847457422 LAAPSVSHVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 LAAPSVSHVSPR 12 0 A0A0U1RRM7;A0A0U1RQW3;A0A0U1RQJ8;Q8WXE1-5;Q8WXE1-3;Q8WXE1-2;Q8WXE1 A0A0U1RRM7 ATRIP ATR-interacting protein 1 LAAPSVSHVS(1)PR;LAAPSVSHVS(1)PR;LAAPSVSHVS(1)PR;LAAPSVSHVS(1)PR 158.25 0.00045232 54694200.0 11432.800000000001 12835.800000000001 12684.400000000001 14452.7 15919.9 11490.8 14104.6 10649.7 3360.3200000000006 6828.07 True False 11699.161995643753 11332.978568798477 10961.928150421816 11928.807255779355 14479.947855886621 11375.212984811631 13040.678666321388 10367.235360899116 5702.217611937649 7704.519295534039 1.5184804589204193 1.4709520651557966 1.4227919653307832 1.548287024564134 1.8794096426340305 1.476433836878743 1.6926012079534254 1.3456044385414847 0.7401133533720873 1.0 12.911489230813745 -8.091459518248541 3.9867880761722305 0.880413328342221 1.5686578163657012 0.7989166945739602 0.13896664556638302 0.1010356322043849 2.816492371365335 0.10571209865934399 0.03714623120065191 8.101034500727165e-09 8.091459518248541 0.6882444880234803 LAAPSVSHVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 LAAPSVSHVSPR 12 0 A0A0U1RRM7;A0A0U1RQW3;A0A0U1RQJ8;Q8WXE1-5;Q8WXE1-3;Q8WXE1-2;Q8WXE1 A0A0U1RRM7 ATRIP ATR-interacting protein 1 LAAPSVS(0.004)HVS(0.996)PR;LAAPSVS(0.019)HVS(0.981)PR;LAAPSVSHVS(1)PR 158.91 0.00030327 40216200.0 98326.0 97309.0 146791.0 173805.0 194727.0 123754.0 117914.0 123906.0 118336.0 158691.0 True False 92861.43455016443 104772.2874022491 137346.62687395653 150132.4591696514 170263.65337853244 140799.99017303917 123397.2346421584 124266.54594625751 142006.50658409882 154109.17850126573 0.6025691360712934 0.6798575426926216 0.8912293752369101 0.9741954413728728 1.1048248717848692 0.9136379256728225 0.8007130778465924 0.8063539573357525 0.9214668974627782 1.0 17.233593263505092 -5.216155219166405 2.9723429445105545 0.9255351118509064 0.6151298579919046 0.655419434734293 0.08392916299082254 0.1838896272938089 3.184672789869207 0.02562811091100084 0.08275013615198036 6.079176894191269e-06 5.216155219166405 -0.31040525385900186 LAAQES(ph)SEAEDMSVPR ddPTM_A459_Selumetinib_30min_R2 1 LAAQESSEAEDMSVPR 16 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;Q5SRD0 A0A0A0MR88 FAM21C;FAM21D WASH complex subunit FAM21C;Putative WASH complex subunit FAM21 1 LAAQES(0.812)S(0.188)EAEDMSVPR 125.41 0.0012078 6439700.0 24615.0 19457.0 27129.0 24527.0 27332.0 23940.0 24231.0 21025.0 18100.0 21759.0 True False 23246.99684165223 20949.289335884303 25383.549675821836 21186.38028856504 23898.309808819784 27237.51769431742 25357.7895128156 21086.179269123877 21720.505756255017 21130.76113332853 1.100149525848639 0.9914119611546788 1.2012605469182833 1.0026321415913781 1.1309725029793711 1.28899841905633 1.2000414633820256 0.9978901912750158 1.0279092939059498 1.0 14.367057113859772 -7.780214601287603 24.976676344972052 1.009674730295347 1.1292952040814714 0.3027316899777228 0.08494807540770873 349.38552978090803 464781.0665227096 0.04981893647777772 0.023998458496648348 1.658767045516434e-08 7.780214601287603 0.11962047378612439 LAAQES(ph)SETEDMSVPR ddPTM_A459_Selumetinib_30min_R1 1 LAAQESSETEDMSVPR 16 0 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 LAAQES(0.538)S(0.462)ETEDMSVPR 317.7 2.5742999999999987e-117 9529000.0 1548.0 1978.2 1515.7 1294.4 1652.7 1598.6 1623.3 1650.6 744.69 1321.9 True False 1584.0653881163419 1746.591424359769 1309.8762651441407 1068.3573388972861 1503.2135768078847 1582.5195354126677 1500.8531740736712 1606.8207260955771 1263.6845399943604 1491.5787413963901 1.062005876158685 1.170968300825098 0.8781811035452659 0.7162594298555828 1.0078003494475942 1.060969489234702 1.0062178632745855 1.0772617505873672 0.8472127584838873 1.0 10.542624425140126 -5.257384949471405 24.998504905133714 0.9517934678702079 1.1164870945761072 0.2819402904337964 0.10670189977683618 474.8840067469169 2927975.1807839065 0.02962419771929052 0.07271429719147511 5.528598486570495e-06 5.257384949471405 0.16469362670589927 LAAQESS(ph)ETEDMSVPR ddPTM_A459_Selumetinib_30min_R1 1 LAAQESSETEDMSVPR 16 0 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 LAAQES(0.07)S(0.93)ETEDMSVPR 317.31 2.6783999999999986e-117 8873700.0 1609.4 2082.6 2043.0 1831.3 2258.0 1684.9 1922.5 1544.7 836.76 1730.2 True False 1646.89588865274 1838.7682238255268 1765.5718213957127 1511.4978327584977 2053.764298682279 1667.9514357667972 1777.4842771863698 1503.7295381072563 1419.9206054676179 1952.288023575182 0.8435721926095802 0.9418529446583558 0.9043603198274299 0.7742186677919198 1.05197812714195 0.8543572544753486 0.9104621120050217 0.7702395957710736 0.7273110259967424 1.0 10.930950195928775 -7.749048046089668 24.852353134819698 0.8115814808050155 0.8988143257550933 0.0763702637642738 0.09504857317505412 376.73104095237136 755584.494597873 0.04297935513026869 0.024582832977643954 1.7821815934179237e-08 7.749048046089668 0.08723284495007788 LAAQESS(ph)ETEDMSVPR ddPTM_A459_Selumetinib_30min_R2 2 LAAQESSETEDMSVPR 16 0 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 LAAQES(0.023)S(0.891)ET(0.086)EDMSVPR;LAAQES(0.065)S(0.9)ET(0.018)EDMS(0.017)VPR 178.02 1.1333e-06 19356900.0 52710.0 42564.0 56161.0 56695.0 65260.0 46735.0 54018.0 53811.0 45398.0 45486.0 True False 49780.589214848245 45828.521935168785 52547.66240347347 48973.04319566988 57061.4553681977 53172.32203190993 56529.94403463637 53967.581101109354 54478.86852610304 44172.70099317902 1.1269537088650108 1.037485164021223 1.1895958640063165 1.1086721457950264 1.2917809888285732 1.2037371688029805 1.2797484139212023 1.2217405747826653 1.233315312426004 1.0 15.430867429956221 -5.750868412514661 1.5693423395934198 1.2168627974038495 1.0892173076121692 0.1744086619180677 0.08482489867245906 0.5246751557832396 2.612048672369706 0.02554488166288438 0.05763947584307542 1.7747271264600785e-06 5.750868412514661 -0.12764548979168033 LAAQLGAPTS(ph)PIPDSAIVNTR ddPTM_A459_Selumetinib_30min_R2 2 LAAQLGAPTSPIPDSAIVNTR 21 0 Q9H8Y5;B8ZZS4 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 1 LAAQLGAPT(0.36)S(0.574)PIPDS(0.021)AIVNT(0.045)R;LAAQLGAPT(0.17)S(0.83)PIPDS(0.001)AIVNTR 118.46 7.5199e-05 9108300.0 25975.2 19532.7 28505.0 35655.0 32837.0 23677.4 24749.9 28486.7 23889.4 31985.0 True False 24531.602370964254 21030.79528247043 26671.019333897362 30798.727491694302 28711.722493495367 26938.746927962864 25900.819390996447 28569.59158077295 28667.947525606534 31061.509942989716 0.7897749470643748 0.6770693157245202 0.8586517327344788 0.991539933126956 0.9243505079499629 0.867271004449115 0.8338557732233495 0.9197747190400456 0.9229412085318349 1.0 14.922840342382043 -5.441238166215971 5.096632218902538 0.9144270453638416 0.7363746238638968 0.6588556155052132 0.05362080890016886 0.13179267309880888 5.875013627035211 0.014463545710791748 0.030663313855361404 3.620443995492091e-06 5.441238166215971 -0.1780524214999447 LACLS(ph)EEGNEIESGK ddPTM_A459_Selumetinib_30min_R2 1 LACLSEEGNEIESGK 15 0 F2Z2C0;Q9Y2L1;Q9Y2L1-2;G3V1J5 F2Z2C0 DIS3 Exosome complex exonuclease RRP44 1 LACLS(1)EEGNEIESGK 131.56 0.0008631 0.0 9396.6 9051.7 8705.5 10338.0 11101.0 7048.4 6676.4 7177.2 5209.1 8806.1 True False 8874.37458957016 9745.936284197156 8145.3976078317355 8929.946565955284 9706.393135800841 8019.253120995274 6986.865829035621 7198.084463750579 6251.065554414803 8551.845012004436 1.0377146191392594 1.139629667108857 0.9524725479002296 1.044212863238295 1.1350057352741703 0.9377219897856486 0.8170009885852684 0.8416995927365907 0.7309610435689641 1.0 13.062019991504544 -6.996762758042145 4.208098537913784 0.837154891992118 1.058783437570191 0.6180705410280637 0.07937161334747687 0.13198614975386466 5.586021894522003 0.029190869407085613 0.024133715662556125 1.0074818754756683e-07 6.996762758042145 0.221628545578073 LADAMAES(ph)PSRDVVGSGTELQR ddPTM_A459_Selumetinib_30min_R2 2 LADAMAESPSRDVVGSGTELQR 22 1 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6 K7ESE9 BCAS3 Breast carcinoma-amplified sequence 3 1 LADAMAES(0.76)PS(0.186)RDVVGS(0.027)GT(0.027)ELQR;LADAMAES(0.822)PS(0.177)RDVVGSGTELQR 62.002 0.006524899999999999 10376400.0 13886.3 18748.0 21199.0 20461.0 22602.2 10403.5 13754.400000000001 16468.1 13574.900000000001 18165.8 True False 13114.55503726327 20185.911315678626 19835.079419726033 17674.176502806262 19762.709569768296 11836.48769142987 14394.006853826555 16516.019444559282 16290.259314397026 17641.306153583322 0.7434004559010177 1.1442413129698132 1.1243543560235254 1.001863260516924 1.1202520605739883 0.6709530228874594 0.8159263678388592 0.9362129595605102 0.9234157138125586 1.0 14.106669760826756 -6.736442497615952 24.999881146781867 0.8619788016635986 1.037377399576543 0.2532439156111601 0.13434421263320137 300.2232646868195 300258.5321332525 0.044199423070574485 0.044181958501716856 1.8346680686705167e-07 6.736442497615952 0.17539859791294432 LADFGVLHR ddPTM_A459_Selumetinib_30min_R1 2 LADFGVLHR 9 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 ; 146.23 0.002483 14691700.0 13392.0 16175.3 16730.6 17095.199999999997 16641.3 13967.5 15128.2 14103.400000000001 9512.7 12684.099999999999 False True 13704.007543704163 14281.488356307042 14458.676414607484 14109.844236647781 15136.097353260151 13826.99963147531 13987.067694216308 13729.332017700448 16142.357119881224 14312.22778859668 0.9575034541179454 0.9978522258907778 1.010232413022904 0.9858593955505551 1.0575640338340544 0.9660969512022456 0.9772809586890837 0.9592728833340218 1.1278717302656898 1.0 13.80496063368296 -4.747772743815747 2.842779546328095 1.0070851361386428 0.9460470003217922 0.09793502031892531 0.047439138063043285 1.2640993656465258 13.139622933166292 0.011796818295616332 0.18857842202713185 1.787422646808002e-05 4.747772743815747 -0.06103813581685058 LADILS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LADILSPR 8 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 LADILS(1)PR 90.827 0.027722000000000004 7265100.0 4445.8 5009.2 5033.0 5293.1 5194.5 3704.9 4032.1 3834.2 2636.1 4060.5 True False 4549.37848997909 4422.720535286099 4349.546244290074 4368.759448792666 4724.65839216346 3667.6320697800516 3727.9554507376665 3732.504560763152 4473.269166873642 4581.704727619367 0.9929444956490957 0.9653002099033398 0.9493292350487367 0.9535226970120909 1.0312009771564592 0.80049507504726 0.8136612183375456 0.8146541042383026 0.9763329225272733 1.0 12.161668770426989 -6.758812471671257 24.99999981921246 0.8652340808851255 0.9747247198803859 0.3343813349030136 0.06679736011295635 72.66928657204033 691586.0453546138 0.02222595332105712 0.02126780655866793 1.7425591478894181e-07 6.758812471671257 0.10949063899526035 LADILS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LADILSPR 8 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 LADILS(1)PR 90.149 0.029403 0.0 40464.0 35415.0 42066.0 45783.0 49280.0 42307.0 38372.0 40515.0 31033.0 40569.0 True False 38215.172870226124 38131.21662282687 39359.51935799777 39547.2764199198 43089.00583121028 48134.40522529183 40156.37403267552 40632.89194238071 37240.46713446749 39397.66755907927 0.9699856676266451 0.967854672250501 0.9990317142245972 1.0037974040117015 1.0936943352444815 1.2217577386557534 1.0192576495158887 1.0313527287230682 0.9452454787741705 1.0 15.265822600587553 -6.05689056286783 4.17470332709171 1.0601190806279324 0.9802329843016935 0.1839935750575733 0.06874062686364588 0.3788567182102399 13.430309853440232 0.022270071006868633 0.03038421614987616 8.772218429439678e-07 6.05689056286783 -0.07988609632623889 LADSGDGAGPS(ph)PEEK ddPTM_A459_Selumetinib_30min_R2 1 LADSGDGAGPSPEEK 15 0 Q92917 Q92917 GPKOW G patch domain and KOW motifs-containing protein 1 LADSGDGAGPS(1)PEEK 130.64 0.00093716 0.0 35699.0 27695.0 35751.0 34927.0 39441.0 31521.0 41735.0 41773.0 32677.0 32170.0 True False 33714.99249441981 29819.117446539312 33450.81958274566 30169.882347564337 34486.0689729863 35862.73163085127 43675.76019633361 41894.55251410756 39213.31307166546 31241.168512301996 1.0791847456391934 0.9544815020218365 1.0707288227574956 0.9657091518738867 1.1038661681110469 1.1479318264529514 1.398019417203783 1.3410046585680855 1.2551807419182877 1.0 14.931160795109234 -6.83529994187562 2.384618107164784 1.2755115855165906 1.0209898273695686 0.4593090377761606 0.10751722942855677 0.22083767003227406 2.5673723147873297 0.040319111226512015 0.035579568320480225 1.461167682578295e-07 6.83529994187562 -0.25452175814702205 LADSGDGAGPS(ph)PEEKDFLK ddPTM_A459_Selumetinib_30min_R1 3 LADSGDGAGPSPEEKDFLK 19 1 Q92917 Q92917 GPKOW G patch domain and KOW motifs-containing protein 1 LADSGDGAGPS(1)PEEKDFLK;LADSGDGAGPS(1)PEEKDFLK;LADS(0.005)GDGAGPS(0.995)PEEKDFLK 81.017 0.0032877 53285000.0 10955.0 11356.400000000001 14757.3 14449.3 10392.400000000001 11159.5 10943.5 11150.7 6563.2 9562.3 True False 11210.230185280709 10026.78740855287 12753.339716046474 11926.001001953458 9452.409254927243 11047.245562015296 10118.022984337604 10854.947213421758 11137.271042837943 10789.714349689617 1.038973769088075 0.9292912753377299 1.1819904867466065 1.1053120236029723 0.876057414365113 1.0238682141138506 0.9377470669210687 1.006045837880223 1.0322118530559916 1.0 13.397369050516131 -6.228655394899682 24.99883742556791 0.9797725626928213 1.0627131707037394 0.24553316178763895 0.07261090154533349 1027.169457491839 783249.4878423847 0.022039543711803736 0.02845110139177526 5.906695802887196e-07 6.228655394899682 0.08294060801091807 LADSGDGAGPS(ph)PEEKDFLK ddPTM_A459_Selumetinib_30min_R2 1 LADSGDGAGPSPEEKDFLK 19 1 Q92917 Q92917 GPKOW G patch domain and KOW motifs-containing protein 1 LADS(0.11)GDGAGPS(0.89)PEEKDFLK 53.201 0.03705 2716500.0 22009.0 20395.0 20054.0 18918.0 19911.0 14072.0 16262.0 17866.0 11246.0 17706.0 True False 20785.827889007684 21959.23091973893 18763.747473144296 16341.335764629735 17409.602173401534 16010.29026710253 17018.215222541676 17917.987102124473 13495.51423949413 17194.781774287192 1.2088451113750385 1.2770869213691576 1.0912466188552221 0.9503659877246197 1.0124933483852399 0.9311133154969182 0.9897313874602612 1.0420595816411435 0.7848610361356904 1.0 14.069683185722296 -5.506460714560238 2.896705157420397 0.9626616156600787 1.2427298292079767 0.7327404826218231 0.06857632785462 0.1258313964155908 2.1135732310375146 0.01836737685260759 0.04068939283045742 3.115582712820055e-06 5.506460714560238 0.280068213547898 LAEAHQQECCQK ddPTM_A459_Selumetinib_30min_R2 2 LAEAHQQECCQK 12 0 A0A087WUY5;Q9Y5X3 A0A087WUY5 SNX5 Sorting nexin-5 0 ; 114.71 0.0093286 0.0 11516.9 9518.0 9582.8 12259.8 12016.0 8398.6 10263.6 10432.0 9533.5 11714.7 False True 10876.836803803557 10247.999994806329 8966.253080963746 10589.994090665377 10506.442655597055 9555.43091510001 10740.877736937571 10462.355392889429 11440.466388246241 11376.466172554057 0.9560821997646453 0.9008069675915554 0.7881404422926167 0.930868507851229 0.9235242733762132 0.8399296205136768 0.9441312947293022 0.919648969565792 1.0056256674719066 1.0 13.47376486803119 -8.048518715001391 1.448054977070482 1.0066449511784896 0.8905332806665204 0.42910077590327933 0.04773056025472663 0.40105993255614636 1.5093416490784783 0.04364675749707048 0.01434980429822316 8.942959933093918e-09 8.048518715001391 -0.11611167051196924 LAEDDWTGMES(ph)EEENKKDDEEMDIDTVK ddPTM_A459_Selumetinib_30min_R1 1 LAEDDWTGMESEEENKKDDEEMDIDTVK 28 2 O95149;H3BTA6;H3BSK1;H3BUB4;H3BRI5 O95149 SNUPN Snurportin-1 1 LAEDDWT(0.163)GMES(0.836)EEENKKDDEEMDIDT(0.001)VK 44.648 0.021539 6924800.0 622.88 835.3 889.09 1141.0 638.16 770.48 826.89 853.8 385.82 713.9 True False 637.3918920865036 737.5026876795653 768.3564614217885 941.7457692226534 580.4385406762988 762.7296707398676 764.5170215670416 831.154450466742 654.708360822119 805.5360189748718 0.7912642974024314 0.9155427818337831 0.953844947119313 1.1690920666975546 0.7205618706100406 0.9468597961771099 0.9490786303261385 1.0318029621126965 0.8127611247667154 1.0 9.653805289239942 -4.779018724746937 3.1061358102613283 0.9483543185837134 0.7667135091804786 0.14606592636980664 0.11344185179888676 0.7183151231730361 10.26496130223169 0.028308022398687464 0.32572158881291874 1.6633409333422512e-05 4.779018724746937 -0.1816408094032348 LAEDEGDS(ph)EPEAVGQSR ddPTM_A459_Selumetinib_30min_R1 3 LAEDEGDSEPEAVGQSR 17 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 LAEDEGDS(1)EPEAVGQSR;LAEDEGDS(1)EPEAVGQSR;LAEDEGDS(1)EPEAVGQSR 227.41 3.1683e-16 407130000.0 6076.46 9678.0 7821.96 10228.220000000001 7377.27 8350.05 7571.710000000001 6323.12 3782.52 5841.87 True False 6218.029695267076 8544.895260819863 6759.7807949507605 8442.053384468478 6709.997231062804 8266.056078238793 7000.569818681303 6155.410317211599 6418.660175669695 6591.730919132558 0.9433075730107838 1.296305229331833 1.0254940436555802 1.2807035796872932 1.0179416170625195 1.254003869339765 1.062022995866243 0.9338078863846621 0.9737442645056212 1.0 12.686441636170425 -7.5477516666495825 5.492281711359506 0.9689391344987732 1.1413421704917814 0.30669242080457515 0.11239977306348689 0.19522766547510084 17.228630522654043 0.04836781636726031 0.028197518913370332 2.833011473264413e-08 7.5477516666495825 0.1724030359930082 LAEDEGDS(ph)EPEAVGQSR ddPTM_A459_Selumetinib_30min_R2 3 LAEDEGDSEPEAVGQSR 17 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 LAEDEGDS(1)EPEAVGQSR;LAEDEGDS(0.997)EPEAVGQS(0.003)R;LAEDEGDS(1)EPEAVGQSR 171.78 7.2927e-09 349780000.0 57600.0 50211.0 60501.0 58581.0 65299.0 43519.7 48535.4 43148.9 43884.1 55805.0 True False 54398.82259106922 54062.02224618834 56608.431528508125 50602.16674213842 57095.55583953328 49514.14364249731 50792.39227107058 43274.45615531505 52662.14622420275 54193.764651197154 1.003783792124276 0.9975690486561187 1.044556175287919 0.9337267316235541 1.0535447427764555 0.9136501950211633 0.9372368315429175 0.79851356394668 0.9717381060929752 1.0 15.72583924913074 -6.783594806732197 24.304987548736193 0.9124478395100568 1.0041885110072502 0.32439236418022843 0.058182564206118045 181.10871254108048 198678.416142006 0.019524088150167672 0.017233576956646485 1.6459066247559808e-07 6.783594806732197 0.09174067149719334 LAEETEGPS(ph)DGESAAEKR ddPTM_A459_Selumetinib_30min_R1 2 LAEETEGPSDGESAAEKR 18 1 Q92766;Q92766-2;A0A087X055;Q92766-4 Q92766 RREB1 Ras-responsive element-binding protein 1 1 LAEETEGPS(1)DGESAAEKR;LAEETEGPS(1)DGESAAEKR 130.01 0.00030922 15810900.0 3673.6 3790.0 5273.5 4944.3 4791.4 3685.8999999999996 4284.4 4097.8 2833.0 3839.0 True False 3759.1877324187312 3346.2650380768014 4557.387665262011 4080.870821005758 4358.0187159903735 3648.82319252943 3961.2242586097695 3989.1130324696796 4807.394085866629 4331.773045026659 0.8678173333052808 0.772493157719487 1.0520836659469919 0.9420786312180035 1.0060588748973927 0.8423394195867835 0.9144579407634665 0.9208961298306267 1.109798236402536 1.0 12.080741942337818 -5.251350623723658 24.952289178204015 0.9638917756884092 0.8201552391870502 0.396022819393809 0.0749899005569096 714.2844135679884 1766614.223239267 0.019136926342108094 0.049352290334902404 5.605952018174396e-06 5.251350623723658 -0.14373653650135898 LAEETEGPS(ph)DGESAAEKR ddPTM_A459_Selumetinib_30min_R2 2 LAEETEGPSDGESAAEKR 18 1 Q92766;Q92766-2;A0A087X055;Q92766-4 Q92766 RREB1 Ras-responsive element-binding protein 1 1 LAEETEGPS(0.995)DGES(0.005)AAEKR;LAEETEGPS(0.994)DGES(0.006)AAEKR 77.631 0.0069852 23238800.0 62321.0 54083.0 61433.0 53193.0 48404.0 39277.0 48184.0 55185.0 34980.0 42637.0 True False 58857.44831072956 58230.99219574605 57480.467663193034 45948.02163695681 42323.056782749634 44687.05022889326 50424.65147478468 55345.579213631434 41976.97742286187 41405.95902576998 1.4214728917182724 1.4063432792247272 1.388217276344661 1.1096958678908986 1.022148931664857 1.079242004781998 1.217811461471082 1.3366573439148166 1.013790729897996 1.0 15.337550790710413 -5.744993771104314 7.2014237624189255 1.1245116402787814 1.4070522028099481 0.6557188562693548 0.097317499735283 0.10382640174189614 24.47930186799546 0.02833254374902774 0.047290353488791174 1.798896715732076e-06 5.744993771104314 0.2825405625311668 LAELEEFINGPNNAHIQQVGDR ddPTM_A459_Selumetinib_30min_R1 1 LAELEEFINGPNNAHIQQVGDR 22 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 176.67 6.7566e-16 13314000.0 2175.1 2830.3 2072.1 2709.8 2091.8 1927.2 2137.9 2265.0 1182.6 1835.5 False True 2225.775597992156 2498.9271602292274 1790.720201230569 2236.5842992458797 1902.597059337286 1907.8141177575953 1976.6364817668361 2204.924842243114 2006.7858263134065 2071.1043042840406 1.0746805911166233 1.2065675084833938 0.8646209645388201 1.0798994017923418 0.918638938368193 0.9211579126224195 0.9543877040273638 1.064613133043212 0.9689448388294145 1.0 11.016184496590416 -5.252333576864224 24.998669663581172 0.973410205042244 1.1406240525329299 0.49304195357237834 0.06856320041717873 523.0926962180308 1436068.5553434752 0.016844370588757554 0.04323044983606164 5.593278228496815e-06 5.252333576864224 0.1672138474906859 LAES(ph)PQLSK ddPTM_A459_Selumetinib_30min_R1 2 LAESPQLSK 9 0 Q96A19 Q96A19 CCDC102A Coiled-coil domain-containing protein 102A 1 LAES(0.997)PQLS(0.003)K;LAES(0.972)PQLS(0.028)K 100.04 0.018273 14538900.0 8769.7 9824.3 10995.7 11680.0 9860.0 9013.400000000001 9975.4 8831.6 5674.299999999999 7975.1 True False 8974.016947134292 8674.066388806836 9502.544335056693 9640.307260754247 8968.164740924387 8922.73337951241 9222.947546759384 8597.357278920214 9628.872665525241 8998.78176905239 0.9972479806096347 0.9639156289618802 1.0559811960033065 1.0712902599669791 0.996597647446758 0.9915490350258835 1.0249106805187698 0.9553912406774092 1.0700195773876626 1.0 13.135513991136994 LAES(ph)PQLSK ddPTM_A459_Selumetinib_30min_R2 2 LAESPQLSK 9 0 Q96A19 Q96A19 CCDC102A Coiled-coil domain-containing protein 102A 1 LAES(0.998)PQLS(0.002)K;LAES(0.998)PQLS(0.002)K 116.74 0.0077544 25843000.0 186142.0 164676.0 184995.0 190412.0 183275.0 134534.0 152569.0 144937.0 111277.0 163628.0 True False 175796.9728254652 177306.11968320303 173092.62310732703 164477.55712097872 160250.35600071153 153064.8373219423 159663.76080973828 145358.74267438796 133535.50933915985 158903.6344833993 1.1063118436339525 1.115809089324047 1.089293040213061 1.035077376648435 1.0084750831640223 0.9632557355881813 1.004783567907746 0.9147603397930688 0.8403552868585289 1.0 17.277792597179953 -6.326975093287158 0.6922992206815278 0.9206381433699412 1.1269526461029455 0.7332603874052608 0.04243359609625473 0.40597341958543703 0.42275309872033384 0.027591786725625417 0.04662924845425164 4.7100433763907104e-07 6.326975093287158 0.20631450273300433 LAETYLHR ddPTM_A459_Selumetinib_30min_R2 1 LAETYLHR 8 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 117.04 0.0096806 0.0 7352.9 10516.0 8833.9 8302.9 11553.0 7839.3 7361.2 7534.2 8474.5 8773.1 False True 6944.255253990846 11322.543385730552 8265.536491623081 7172.030696698606 10101.608854869562 8919.092416919899 7703.510385941082 7556.12327464605 10169.636797313977 8519.797807748733 0.8150727764542797 1.3289685555017197 0.9701564142878599 0.8418076178023455 1.1856629796639278 1.046866676672539 0.9041893434295776 0.8868899761651358 1.1936476694393756 1.0 13.056603477411379 LAFPS(ph)PFGHLSEGFSHSR ddPTM_A459_Selumetinib_30min_R1 2 LAFPSPFGHLSEGFSHSR 18 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8 Q13501 SQSTM1 Sequestosome-1 1 LAFPS(1)PFGHLSEGFSHSR;LAFPS(1)PFGHLSEGFSHSR 123.61 0.00058468 9130200.0 4594.1 4394.3 4340.8 5162.7 7155.3 4487.700000000001 5799.9 4348.0 1768.98 2680.31 True False 4701.133591437522 3879.8133131453556 3751.3432023076407 4261.1313608815035 6508.104378370818 4442.557812505584 5362.408873473719 4232.676915705541 3001.8298588126904 3024.353896930295 1.5544257555999483 1.28285691601216 1.2403783849883563 1.4089393986618206 2.1518990832972666 1.4689278979602087 1.7730758556121817 1.3995309609770499 0.9925524462793636 1.0 11.562411252089152 -8.176090092582237 3.670097535645986 0.9881545840086492 1.5478488590943047 0.441158880593996 0.24692027999785954 0.2383695949183654 5.771905214044819 0.21251521542464738 0.06909885082351723 6.666684572719803e-09 8.176090092582237 0.5596942750856555 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLS(ph)SGSPR ddPTM_A459_Selumetinib_30min_R1 1 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPR 45 1 O14686;O14686-3;F8VWW4 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVS(0.055)VLS(0.396)S(0.308)GS(0.241)PR 84.32 8.9e-16 18208000.0 750.21 904.23 1038.0 944.44 951.13 673.9 940.23 1005.5 389.51 500.37 True False 767.6884333454528 798.3623312348776 897.0453013258688 779.5112833344815 865.1004594356406 667.1211778522436 869.3076941164837 978.8308736756954 660.9700213151826 564.5973635165384 1.3597095611002892 1.414038362245189 1.5888230432723092 1.3806498820316362 1.5322431795420521 1.1815874833299713 1.5396949229484307 1.7336794978622374 1.170692716661652 1.0 9.141078581668076 -8.495437959256181 8.404394810694571 1.0000322925403564 1.4607092002995896 0.5533205970236824 0.14106614416109275 0.17266392354119672 47.885138341767096 0.13587547903997438 0.03511330201381411 3.1956708468590416e-09 8.495437959256181 0.4606769077592332 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLS(ph)SGSPR ddPTM_A459_Selumetinib_30min_R2 2 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPR 45 1 O14686;O14686-3;F8VWW4 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVS(0.147)VLS(0.284)S(0.284)GS(0.284)PR;LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVS(0.134)VLS(0.384)S(0.279)GS(0.203)PR 101.72 8.379399999999997e-21 35242000.0 140761.0 123298.0 163644.0 148472.0 169266.0 126182.0 115279.0 121094.0 105084.0 152823.0 True False 132938.0671309286 132754.56013444316 153115.32320211557 128249.85747151385 148001.29182276063 143562.4251338496 120639.7019210051 121446.36349180921 126103.73629228168 148410.60290816057 0.8957450783566543 0.8945085966438282 1.0317007019833102 0.864155626069907 0.9972420360986389 0.9673326724687514 0.8128779181340523 0.8183132546598617 0.8496949262467264 1.0 17.17923464063128 -7.25428752879662 24.70251840254383 0.8550809619101645 0.942711869491774 0.19690846291077846 0.06809020181606962 621.1200297866467 2145355.6975685167 0.025452470299006182 0.019280174475828676 5.5681698088860405e-08 7.25428752879662 0.08763090758160952 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVSVLSSGSPR 45 1 O14686;O14686-3;F8VWW4 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LAGEDKDSEPAADGPAASEDPSATESDLPNPHVGEVS(0.062)VLS(0.319)S(0.189)GS(0.43)PR 119.14 1.379e-34 19236000.0 946.27 1064.3 1096.6 962.05 996.43 762.66 933.52 748.54 269.47 641.29 True False 968.3162498791031 939.6912612203535 947.6877431926273 794.0460274151216 906.3030824340044 754.9883328398756 863.1038348187361 728.6862875994087 457.2709086898981 723.6058181935778 1.338181956989269 1.2986231420391494 1.3096740232941348 1.0973461067482735 1.2524817513166426 1.043369627298799 1.1927817785840966 1.0070210455445396 0.6319337092001791 1.0 9.499060197851728 LAGESESNLR ddPTM_A459_Selumetinib_30min_R2 1 LAGESESNLR 10 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 138.08 0.023215 4354900.0 17226.0 17176.0 21197.0 25997.0 17192.0 16651.0 15790.0 16836.0 18721.0 20831.0 False True 16268.64788114163 18493.3439704553 19833.208097548588 22456.1637526736 15032.187261569956 18944.52410727149 16524.266287291422 16884.989972650154 22465.723108444752 20229.554904562097 0.8042019687478532 0.9141745361033498 0.9804075369486194 1.1100671200437222 0.7430804747058449 0.9364775545802635 0.8168378575430213 0.8346693761829782 1.1105396640920835 1.0 14.304176957278312 -8.263073312946934 24.99925672266869 1.0552698384987094 0.8973598111804603 0.2907472290768426 0.10146829517192814 199.73821917766304 3055859.542668988 0.08444498857859296 0.026188430193593168 5.456657398651397e-09 8.263073312946934 -0.1579100273182491 LAGGQTSQPTTPLTS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 LAGGQTSQPTTPLTSPQR 18 0 O95155-2;O95155;O95155-4;B1AQ61 O95155-2 UBE4B Ubiquitin conjugation factor E4 B 1 LAGGQTSQPTTPLT(0.043)S(0.957)PQR;LAGGQTSQPTT(0.002)PLT(0.067)S(0.93)PQR 193.27 4.1248e-21 4088200.0 39881.0 39677.0 41501.0 46444.0 49617.0 40775.0 45793.0 42303.0 43646.0 46558.0 True False 37664.5736762922 42720.0983183369 38830.8708428723 40118.247079631175 43383.66887839205 46391.38613140319 47922.465237108074 42426.094726361356 52376.41957113293 45213.74956778851 0.8330336244248466 0.9448475016275104 0.8588288123428819 0.8873019261426726 0.9595238017883777 1.0260459832434172 1.0599091138251742 0.9383449754095786 1.1584179607268692 1.0 15.464473944597275 -6.524114186001203 2.2213717183984434 1.0356316448640093 0.8829279548154498 0.6169236367576012 0.05780121588897419 0.208349624492597 2.066522123169442 0.019749161851489748 0.021246474650940643 2.991478004876734e-07 6.524114186001203 -0.15270369004855944 LAGS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 2 LAGSPIR 7 0 A0A0A0MRB5;Q8WXG6-6;Q8WXG6-8;Q8WXG6-5;Q8WXG6-4;Q8WXG6-7;Q8WXG6-3;Q8WXG6-2;Q8WXG6;F8W8U2 A0A0A0MRB5 MADD MAP kinase-activating death domain protein 1 LAGS(1)PIR;LAGS(1)PIR 110.12 0.015552000000000003 85227000.0 342400.0 277220.0 348910.0 389030.0 424410.0 377860.0 412300.0 395080.0 362420.0 321680.0 True False 323370.7787357999 298481.8825972068 326461.510464485 336043.442885818 371091.8215264599 429906.78512843646 431472.7669569513 396229.6173909849 434914.1268608802 312392.2625749861 1.0351433677336312 0.9554714324128298 1.0450371202331612 1.0757098787142807 1.187903370165526 1.376176162574585 1.3811890326617207 1.2683720592979624 1.392205182279392 1.0 18.252999195256855 -6.320018454804774 2.094025680628075 1.3056307939458556 1.010678504827168 0.542622434256254 0.10989933842748963 0.2178082781278938 1.8757365009873475 0.03591045439932896 0.04454590187499784 4.786097539632774e-07 6.320018454804774 -0.29495228911868754 LAHCEELR ddPTM_A459_Selumetinib_30min_R1 2 LAHCEELR 8 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 ; 132.08 0.0047828 6088600.0 1722.55 2153.9 1979.65 2359.9 2089.29 1992.9699999999998 2034.26 1813.78 1265.32 1740.1399999999999 False True 1762.682063501166 1901.7203866790564 1710.824403439071 1947.7877658094144 1900.3140883941096 1972.9225312719766 1880.8141304078777 1765.672662412236 2147.155624683644 1963.5039193989824 0.8977227119774293 0.9685340415623731 0.8713119370613452 0.9919958633979307 0.9678178228316372 1.0047968388450568 0.9578866188276234 0.8992458048938851 1.0935326400269556 1.0 10.939214762468705 -3.1453901412154472 0.20544596982667304 1.0132417363600354 0.7183521165001161 0.25995312120081815 0.05285925393334779 42.23484066881011 0.9210414264699851 0.09695436297141331 3.5338298135967485 0.0007155003635847398 3.1453901412154472 -0.29488961985991935 LAHCEELR ddPTM_A459_Selumetinib_30min_R2 2 LAHCEELR 8 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 ; 139.97 0.0033313 3628800.0 6321.799999999999 5740.299999999999 9043.2 10158.5 9240.2 5917.6 6009.200000000001 7033.0 9853.0 9149.3 False True 5970.459664170511 6180.562552026347 8461.37035749169 8774.894775610057 8079.36346756391 6732.69568537564 6288.639707003903 7053.464865624169 11823.875315822123 8885.135936263741 0.671960418726146 0.6956069773565349 0.9523062357388933 0.9875926309462811 0.9093123082775632 0.7577481913244406 0.7077707929416686 0.7938499665307538 1.3307478243033095 1.0 13.117178133293459 -1.9594685034691919 0.1361007912399405 1.0735474898280424 8.706854725353976e-14 0.23337697176617134 0.16717289159168022 131.0093364477673 1.3391604187952881 0.8693079309764428 26.665827430610992 0.01097820905137798 1.9594685034691919 -1.0735474898279553 LAHEVGWK ddPTM_A459_Selumetinib_30min_R2 1 LAHEVGWK 8 0 Q8J015;M0QYS1;P40429 Q8J015 RPL13a;RPL13A 60S ribosomal protein L13a 0 89.296 0.041964 5335700.0 135630.0 117820.0 145710.0 151720.0 152010.0 121270.0 122370.0 125890.0 125390.0 129400.0 False True 128092.22756990833 126856.41514898963 136335.1772370525 131055.4742684015 132913.14481335777 137973.84172054598 128060.44747155487 126256.31905778857 150471.50368932687 125663.88577842354 1.0193241023579882 1.0094898336397842 1.0849193178495615 1.0429048366328943 1.0576876879942776 1.0979593768398022 1.0190712047322574 1.0047144275039341 1.1974124686438972 1.0 16.939210571336368 -5.246779561611692 23.553876949481268 1.0620123389532732 1.0144069500450905 0.11344529896699662 0.0543643203389182 825.9026222724068 1326960.6028551243 0.013197293208826844 0.03452677253071963 5.66526772681287e-06 5.246779561611692 -0.047605388908182666 LAIQGPEDS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 4 LAIQGPEDSPSR 12 0 Q15773 Q15773 MLF2 Myeloid leukemia factor 2 1 LAIQGPEDS(0.774)PS(0.226)R;LAIQGPEDS(0.5)PS(0.5)R;LAIQGPEDS(0.999)PS(0.001)R;LAIQGPEDS(0.999)PS(0.001)R 204.67 2.8476e-05 578786000.0 12333.400000000001 13875.199999999999 14230.7 14796.0 12686.000000000002 11487.900000000001 12052.7 11251.3 6715.800000000001 9329.2 True False 12620.744223381203 12250.68513359452 12298.24910363972 12212.156355318484 11538.553539895207 11372.342156178642 11143.555135315564 10952.878974626898 11396.222097374915 10526.693694103338 1.198927658591498 1.163773307136019 1.1682917220749705 1.1601132046009166 1.096123234435773 1.0803337198411125 1.058599733129669 1.0404861481589696 1.082602232813011 1.0 13.361764754171357 -6.301954416048236 0.41231390590895545 1.0170435439376544 1.2269466066125527 0.9057656275703041 0.01888561272663202 0.5078690089258491 0.15551385756518005 0.01866548303842798 0.04622091896970281 4.989368535868372e-07 6.301954416048236 0.20990306267489833 LAIQGPEDS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 LAIQGPEDSPSR 12 0 Q15773 Q15773 MLF2 Myeloid leukemia factor 2 1 LAIQGPEDS(0.744)PS(0.256)R 193.98 0.0001591 155060000.0 48496.0 47984.0 55902.0 61926.0 62296.0 46483.0 47738.0 47728.0 39936.0 55096.0 True False 45800.78646486963 51664.21850712198 52305.326181495584 53491.57197169155 54469.81954669392 52885.611319338175 49957.911591052456 47866.88057820428 47924.315905071824 53505.23532340041 0.8560057009008003 0.9655918377865116 0.9775739862715818 0.9997446352375374 1.018027847508067 0.9884193761541827 0.9337013712600841 0.894620503748533 0.8956939562157615 1.0 15.707392441260943 -9.831993843471757 9.323679929099473 1.0000000393665365 0.9519358000945769 0.08483760651021799 0.049811610344776006 0.0 0.0 0.05267599229440602 0.012775804715532826 1.4723333739798585e-10 9.831993843471757 -0.048064239271959575 LAIQGPEDSPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LAIQGPEDSPSR 12 0 Q15773 Q15773 MLF2 Myeloid leukemia factor 2 1 LAIQGPEDS(0.089)PS(0.911)R 104.9 0.0095466 2057800.0 1092.6 1462.4 1387.3 1322.5 1267.6 959.47 1166.3 1136.6 767.66 1197.3 True False 1118.0554541704878 1291.181528148684 1198.912279893427 1091.550201399614 1152.9458038129567 949.8186029290579 1078.3250520064835 1106.4536758028796 1302.662952331937 1350.985117689612 0.8275853223923969 0.955733346905256 0.8874355936235238 0.8079661182843593 0.8534111802687121 0.7030563035019888 0.7981768547166395 0.818997679038154 0.9642319040195549 1.0 10.399796066835934 -8.341319761144943 4.166027848700961 0.995663908421044 0.8319849957630444 0.493323444619427 0.061352511351297885 0.21129966452340262 6.4700298001381595 0.06450020720745239 0.01721238360893261 4.5570126992632656e-09 8.341319761144943 -0.1636789126579996 LAIQGPEDSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 5 LAIQGPEDSPSR 12 0 Q15773 Q15773 MLF2 Myeloid leukemia factor 2 1 LAIQGPEDS(0.355)PS(0.645)R;LAIQGPEDS(0.287)PS(0.713)R;LAIQGPEDS(0.099)PS(0.901)R;LAIQGPEDS(0.015)PS(0.985)R;LAIQGPEDS(0.014)PS(0.986)R 179.55 0.00010389 400734000.0 221483.0 191378.0 228322.0 232478.0 258628.0 197346.0 185670.0 171729.0 152402.0 204486.0 True False 209173.86152669732 206056.07722274025 213632.01109819734 200814.09535308124 226136.83847634448 224528.620171377 194304.0228981254 172228.7029587338 182886.65846766683 198581.957861566 1.0533376938126224 1.0376374542866806 1.075787616350942 1.0112403841494566 1.1387582281467248 1.1306597164677907 0.9784575849210692 0.8672928035023031 0.9209631148624259 1.0 17.599375027383388 -7.480295710078674 5.466583210803927 0.9203532058742628 1.072321368703598 0.6623218742173779 0.04727823514844829 0.11484292274654695 8.646176060197634 0.021334968391819017 0.013715050929715023 3.309057318327418e-08 7.480295710078674 0.15196816282933512 LAIRES(ph)IESEIR ddPTM_A459_Selumetinib_30min_R1 2 LAIRESIESEIR 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 LAIRES(0.998)IES(0.002)EIR;LAIRES(0.993)IES(0.007)EIR 74.296 0.028504 13405300.0 2939.2 3997.9 2641.6000000000004 2716.5 2847.7 2829.8 2969.0 2704.3 1674.42 2234.74 True False 3007.6776413123716 3529.824009426713 2282.885229270149 2242.1142700204555 2590.1260378022685 2801.3347812528236 2745.045939644388 2632.5731791956064 2841.3684452018365 2521.590647210962 1.1927699861351615 1.3998402212234253 0.9053353809807171 0.8891666347590459 1.0271794276628965 1.1109395509343583 1.0886167993526554 1.0440129059438725 1.1268159042168755 1.0 11.300118373503267 -5.259194862844741 24.999926342056852 1.0262898252342043 1.2963051092239462 0.6062175826969178 0.0877687857516463 134.9599655215075 1503188.7465657054 0.024171852358198784 0.0579090950853471 5.5056061088301185e-06 5.259194862844741 0.27001528398974184 LALDGETLGEEEQEDEQPPWAS(ph)PSPTSR ddPTM_A459_Selumetinib_30min_R1 2 LALDGETLGEEEQEDEQPPWASPSPTSR 28 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LALDGETLGEEEQEDEQPPWAS(0.623)PS(0.233)PT(0.087)S(0.057)R;LALDGETLGEEEQEDEQPPWAS(0.657)PS(0.218)PT(0.073)S(0.052)R 125.94 2.3982e-12 10422700.0 388.82 561.86 727.05 519.27 738.56 626.98 500.19 571.87 212.83999999999997 349.47 True False 397.87874948798185 496.07716999837277 628.3206033997808 428.58924240512476 671.7573784033582 620.6731504522918 462.4602655947209 556.7021499044456 361.17393478145226 394.327878626066 1.0090048689285878 1.2580322033705198 1.5933963522665509 1.0868854718018763 1.7035503062677786 1.574002712196935 1.1727810552123392 1.4117747693724596 0.9159229016215386 1.0 8.623251901066935 -8.262231531978603 24.983051988024286 0.9579614024639997 1.3605643826026284 0.345248365956758 0.21629439639494602 78.59814227412065 2478603.641936231 0.1738285743235899 0.05493823121422897 5.4672441432707686e-09 8.262231531978603 0.4026029801386286 LALDGETLGEEEQEDEQPPWAS(ph)PSPTSR ddPTM_A459_Selumetinib_30min_R2 1 LALDGETLGEEEQEDEQPPWASPSPTSR 28 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LALDGETLGEEEQEDEQPPWAS(0.631)PS(0.286)PT(0.049)S(0.034)R 117.65 2.7355e-12 1616000.0 4330.5 3176.0 3628.1 3923.5 3031.6 3326.4 3956.3 2805.7 2472.0 3496.2 True False 4089.8281463650214 3419.58898755042 3394.6719959766024 3389.1125315849854 2650.743305152132 3784.5814059472636 4140.275789259726 2813.864122491362 2966.4690734509595 3395.2556217814827 1.2045714968050323 1.007166872977938 0.999828105488984 0.9981906840365457 0.7807198044668263 1.1146675913495734 1.2194297721499192 0.8287635559572196 0.8737100836886208 1.0 11.72930448075025 -4.624380003388698 2.2142510810353024 0.9777971120135995 1.3418577680267074 0.23378696468398064 0.12269823407323587 1.9400346053359125 7.4027095509628795 0.034133767626562256 1.6328157479832432 2.3747614844125813e-05 4.624380003388698 0.3640606560131079 LALDGETLGEEEQEDEQPPWASPS(ph)PTSR ddPTM_A459_Selumetinib_30min_R1 1 LALDGETLGEEEQEDEQPPWASPSPTSR 28 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LALDGETLGEEEQEDEQPPWAS(0.117)PS(0.638)PT(0.147)S(0.098)R 127.67 2.2486e-12 8020700.0 925.38 742.37 706.6 903.58 954.65 755.17 699.84 731.1 562.46 791.15 True False 946.9395535239668 655.4529752815504 610.6476010759718 745.7867152972877 868.3020760571472 747.5736754394995 647.0505053555837 711.7088530525118 954.4535395469625 892.7018089535927 1.0607568440282993 0.7342350701068471 0.6840443191122921 0.8354264635931276 0.9726675440200504 0.8374282072036916 0.7248226662764842 0.7972526166231956 1.0691739727353682 1.0 9.802034539157077 -8.26019042820258 24.99595404686129 1.0345870045705623 0.8242841788205253 0.3570020145049021 0.10909892083848735 118.14898088642241 2364713.8659922606 0.0859632857084887 0.028344456194311352 5.4929996556689035e-09 8.26019042820258 -0.210302825750037 LALEDSENTASTNCDS(ph)SSEGLEKDTATQR ddPTM_A459_Selumetinib_30min_R2 1 LALEDSENTASTNCDSSSEGLEKDTATQR 29 1 Q49AR2 Q49AR2 C5orf22 UPF0489 protein C5orf22 1 LALEDS(0.008)ENT(0.041)AS(0.099)T(0.099)NCDS(0.33)S(0.33)S(0.093)EGLEKDTATQR 52.144 0.0088348 3232200.0 4419.5 5511.3 5411.7 6137.5 5011.5 1667.8 3547.2 2807.3 2028.6 5568.0 True False 4173.88188266025 5933.998988377405 5063.517113813448 5301.561912221955 4381.910566621555 1897.5243112189876 3712.1518286434552 2815.4687782264673 2434.37668381983 5407.237372598619 0.7719065384130454 1.0974178826415446 0.9364332957663397 0.9804566633393647 0.8103788061584004 0.350923064860212 0.6865154186599844 0.5206852564849405 0.4502071050470479 1.0 12.400675975417862 -6.551791865221589 7.328327676479493 0.5763320833615648 0.9495352815341511 0.45486390135279764 0.1777904726386 0.1485676270056214 28.101975242072967 0.05480569762756892 0.055347709799417666 2.8067784587443517e-07 6.551791865221589 0.3732031981725863 LALPGFS(ph)TPR ddPTM_A459_Selumetinib_30min_R2 1 LALPGFSTPR 10 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2;H0YBM4 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 LALPGFS(0.5)T(0.5)PR 82.831 0.041651 2691700.0 81239.0 73922.0 87363.0 88558.0 92530.0 68680.0 65154.0 65248.0 57854.0 88132.0 True False 76724.06160548389 79591.57970330663 81742.1596936422 76496.24762892908 80905.55417130445 78140.04658503424 68183.79010020182 65437.8608776121 69426.41657582195 85587.400165564 0.8964410819474071 0.9299450567413101 0.9550723533547765 0.8937793119191774 0.9452974855504106 0.9129853977790742 0.7966568673461761 0.7645735324478398 0.811175668866217 1.0 16.385110804019135 -7.195642817848353 6.1924077580767225 0.8236504997907833 0.9244736361344684 0.2592771806539629 0.06219751572973878 0.23857069328242603 17.692006592049253 0.02277291936811374 0.01749468049180452 6.373194639063105e-08 7.195642817848353 0.10082313634368512 LALPGFST(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LALPGFSTPR 10 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2;H0YBM4 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 LALPGFS(0.08)T(0.92)PR 117.02 0.01439 6602600.0 4308.2 5436.0 4919.5 4797.1 4838.4 4690.5 5385.8 4449.5 2869.7 4173.6 True False 4408.572677702082 4799.5505928721595 4251.458920879198 3959.3765377195377 4400.7675742889005 4643.317828633253 4979.544769867545 4331.48480598708 4869.671305404687 4709.3222143066605 0.9361374051469831 1.0191595253965402 0.9027751186706869 0.8407529486283972 0.9344800321625077 0.985984313098626 1.0573803497114644 0.9197681978158702 1.0340492928283596 1.0 12.20130372063125 -6.776867116821577 4.558342109628875 0.999043325843049 0.9251377467203237 0.3273440482218297 0.05250418045202271 0.2652650330993466 13.37285538071325 0.019550464942751176 0.018039310432348812 1.671602004202456e-07 6.776867116821577 -0.07390557912272533 LALPGHAESYNPPPEYLLS(ph)EEER ddPTM_A459_Selumetinib_30min_R1 1 LALPGHAESYNPPPEYLLSEEER 23 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 LALPGHAESYNPPPEYLLS(1)EEER 150.73 4.7385e-08 14888000.0 3424.7 3706.5 3587.9 3296.4 4011.1 3382.8 3743.7 3606.7 1843.9 2944.1 True False 3504.4888466938232 3272.541256894898 3100.6828869239716 2720.745621091636 3648.296713217222 3348.7721033366506 3461.30969492984 3511.038599787301 3128.9636268723893 3322.0039129624865 1.054932185064346 0.9851105966869621 0.9333772530565306 0.8190073498936182 1.0982216784819363 1.0080578443239379 1.0419342618543528 1.0569038122102143 0.9418904097804183 1.0 11.697838057302608 -6.296927320673741 24.999360873388394 1.027395980043053 0.9496976865868112 0.239811725431597 0.06648968275517601 901.9754116322198 635391.375666879 0.021191525986663035 0.024029868937073186 5.047457598670353e-07 6.296927320673741 -0.0776982934562418 LALPGHAESYNPPPEYLLS(ph)EEER ddPTM_A459_Selumetinib_30min_R2 2 LALPGHAESYNPPPEYLLSEEER 23 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 LALPGHAESYNPPPEY(0.105)LLS(0.895)EEER;LALPGHAESYNPPPEYLLS(1)EEER 137.58 2.892200000000001e-06 6960400.0 14979.3 13563.900000000001 15366.3 20251.1 21003.7 17362.9 16349.5 15760.599999999999 15404.7 17201.4 True False 14146.81047288894 14604.20751518739 14377.648987562428 17492.865244903966 18365.0274305396 19754.4818702867 17109.78414591965 15806.460736692214 18486.07044328074 16704.75088739544 0.8468734773868078 0.8742547322993597 0.8606922117234969 1.0471790547983086 1.0993894823296602 1.1825666843791387 1.0242465907605858 0.9462254686251544 1.1066355055452755 1.0 14.02797084793326 -5.775349931210208 5.791826730405357 1.0621922056557378 0.860773769378305 0.6884413868990172 0.06087363410962789 0.09623932865830222 10.636324289568186 0.018357931588076443 0.029150422513334388 1.6774518726647793e-06 5.775349931210208 -0.20141843627743283 LALS(ph)PLSLGK ddPTM_A459_Selumetinib_30min_R1 2 LALSPLSLGK 10 0 P49454 P49454 CENPF Centromere protein F 1 LALS(0.788)PLS(0.212)LGK;LALS(0.919)PLS(0.081)LGK 147.58 0.00081938 124236000.0 25466.0 28258.0 29062.0 30149.0 28706.0 22548.0 27339.0 26191.0 14453.599999999999 22415.0 True False 26059.308251789917 24949.540223212207 25115.540026139097 24884.043116821897 26109.547368455947 22321.187591945974 25276.797219244836 25496.329599642097 24526.703550823135 25292.18359058937 1.0303305034321344 0.9864525984421268 0.9930158831949963 0.9838629799477127 1.0323168529494107 0.882533036817397 0.9993916550823132 1.0080715058991065 0.9697345214570143 1.0 14.62640397642892 -1.5228803249588834 0.9842398667767995 0.9811568179062926 43.15489204217029 0.11905580019733808 0.03746218332139059 3336.9980336655794 4.911322763046897 0.01204432611304335 317241.82308654144 0.029999890879870313 1.5228803249588834 42.17373522426399 LALS(ph)PLSLGK ddPTM_A459_Selumetinib_30min_R2 1 LALSPLSLGK 10 0 P49454 P49454 CENPF Centromere protein F 1 LALS(0.699)PLS(0.301)LGK 126.66 0.0034191000000000004 40732000.0 179160.0 176670.0 181430.0 199140.0 186680.0 149920.0 165480.0 175790.0 153190.0 185680.0 True False 169203.00443430498 190220.0209164148 169756.9913260484 172016.78846433893 163227.58945962548 170570.11916174056 173175.1478923993 176301.5197963988 183832.28048622678 180318.93594542192 0.9383540533176091 1.0549087366730563 0.9414263146352506 0.953958537756701 0.9052160196255286 0.945935701469356 0.960382485535602 0.9777204976950445 1.0194840576359006 1.0 17.460191381800975 -8.03798429612226 3.089757186224075 1.0093020650090816 0.9578765159694692 0.2465536311347004 0.03637470068656567 0.4084696573664264 7.522018161852396 0.029141392631657236 0.010254702130898234 9.162536208093494e-09 8.03798429612226 -0.051425549039612384 LAMENNIK ddPTM_A459_Selumetinib_30min_R2 1 LAMENNIK 8 0 Q5VVL7;P11182 Q5VVL7 DBT Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial 0 90.37 0.047918 0.0 180890.0 156790.0 194630.0 179110.0 206550.0 166720.0 178290.0 189630.0 140640.0 173180.0 False True 170836.85796004336 168815.28884068964 182107.7176971214 154714.9090180159 180601.34241957145 189684.16666652443 186580.8382749326 190181.79190506355 168771.92980992878 168179.84342432301 1.015798650311599 1.0037783684621668 1.0828153599694936 0.9199372877739298 1.0738584288243662 1.1278650449682328 1.1094126054344295 1.1308239324805942 1.0035205549817996 1.0 17.359645281490472 -6.494285108071855 24.798271026862675 1.0864903683224463 1.0092111422859615 0.2473046177245477 0.05659297105184657 793.4836609242157 688161.647531486 0.01695552703882946 0.019184949203483983 3.2041651456336946e-07 6.494285108071855 -0.07727922603648474 LAPDYDALDVANK ddPTM_A459_Selumetinib_30min_R2 1 LAPDYDALDVANK 13 0 H7BY10;K7EJV9;K7ERT8;A8MUS3;P62750;K7EMA7 H7BY10 RPL23A 60S ribosomal protein L23a 0 180.97 0.001575 4034800.0 15690.0 16456.0 20636.0 18345.0 17565.0 13880.0 16808.0 12601.0 13775.0 15620.0 False True 14818.012612046454 17718.12228562019 19308.302226777978 15846.379353109856 15358.32766690764 15791.84400990501 17589.605304420158 12637.666823792153 16530.38490565815 15169.010014366087 0.9768608892744342 1.168047372164691 1.2728782042131752 1.0446548151858464 1.012480554259128 1.041059633749932 1.159575034083411 0.8331240345825747 1.0897471153359874 1.0 13.888839312598474 -5.973622729814927 24.98662200298817 1.0226751145822959 1.144911724484034 0.20622010210853325 0.10260491944498207 328.4499727133418 311131.21039732563 0.028711862492546942 0.04258555653727162 1.0626182493418924e-06 5.973622729814927 0.12223660990173824 LAPGGHVGR ddPTM_A459_Selumetinib_30min_R1 1 LAPGGHVGR 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 134.81 0.0039245 11012000.0 8582.8 7679.8 8512.0 8386.3 8520.0 7723.1 7639.7 7191.0 4105.1 6318.9 False True 8782.762540778387 6780.645445757844 7356.117153069159 6921.790135347889 7749.367504328175 7645.412626013744 7063.431278242245 7000.271320340054 6966.054875358668 7129.99236629824 1.2318053217409313 0.9510031844926405 1.031714590304438 0.9707990948301048 1.086868976320027 1.07228903387776 0.9906646340365505 0.9818062854356835 0.9770073399076182 1.0 12.799684816715603 -4.751966180250267 24.99963489927302 1.0100188134978807 1.2318057594821619 0.7203772082159725 0.041995174610463745 216.21599406677845 570550.7115140391 0.010958087677252525 0.1370605537118444 1.7702468071168912e-05 4.751966180250267 0.22178694598428117 LAPGGHVGR ddPTM_A459_Selumetinib_30min_R2 4 LAPGGHVGR 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 ;;; 134.81 0.0039245 32572400.0 207204.0 199765.0 207384.0 234514.0 229215.0 190900.0 184244.0 200849.0 170976.0 195045.0 False True 195688.43118333182 215086.33315428556 194041.139222627 202572.78864078477 200418.9624919006 217194.74218233902 192811.71107256 201433.43733765787 205175.97746858883 189413.5440622297 1.0331279748350022 1.1355382964780034 1.02443117351142 1.069473619976361 1.0581025949551697 1.1466695439212211 1.0179404647495212 1.0634584677401906 1.0832170343699423 1.0 17.5311799691966 -14.02802621559049 0.45692983774251317 1.5766923448696808e-06 1.0717350874254292 0.20835023365184357 0.040885882861627365 1368.401911794875 12.475244596621026 1368.4910527568945 0.020558465975094208 9.375054139898872e-15 14.02802621559049 1.0717335107330843 LAPPS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 1 LAPPSPAR 8 0 O75145-2;O75145 O75145-2 PPFIA3 Liprin-alpha-3 1 LAPPS(1)PAR 101.66 0.01685 32123000.0 922.18 1071.6 1103.4 1174.9 1172.7 1248.6 1424.3 1357.8 846.01 1349.9 True False 943.664999750083 946.1365738266759 953.5643405423539 969.725770604467 1066.6294920570012 1236.040217638094 1316.863904289491 1321.7867332440178 1435.6171798743485 1523.1728141394858 0.6195390247187448 0.6211616732151265 0.6260381827265402 0.6366485546502563 0.7002682047339401 0.8114904665866118 0.8645531827151546 0.8677851396597827 0.9425175965245928 1.0 10.57286391917153 -7.080670182978088 0.6437740735518345 0.9805537385574293 0.5973569968429645 0.9786949899740882 0.02017437974258093 0.10876933381024655 0.09366879659002944 0.018744504373611297 0.015058550190602284 8.30481221904974e-08 7.080670182978088 -0.38319674171446483 LAPS(ph)EDELTCFSK ddPTM_A459_Selumetinib_30min_R1 4 LAPSEDELTCFSK 13 0 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 LAPS(1)EDELTCFSK;LAPS(1)EDELTCFSK;LAPS(1)EDELTCFSK;LAPS(1)EDELTCFSK 209.11 8.8447e-06 31912100.0 8194.83 8070.800000000001 8834.2 9689.699999999999 8124.419999999999 8011.1 8344.8 7407.199999999999 4564.13 6497.2699999999995 True False 8385.753594636597 7125.866983986873 7634.564162787078 7997.575793196094 7389.567645482847 7930.515607496816 7715.34501756298 7210.736994023483 7744.995259133944 7331.2578932691795 1.1438355759296845 0.9719842198607042 1.0413716546237397 1.0908872542239525 1.0079535808264501 1.0817400946674942 1.052390344179057 0.9835606793540373 1.0564347035512986 1.0 12.839845041095533 -7.713655818377423 22.2664707916715 1.0149983322535103 1.0524780461159413 0.1426842259180806 0.04710947482838535 80.83885032043347 37669.04029043127 0.021049421794192547 0.012152754640041022 1.933500023210722e-08 7.713655818377423 0.037479713862430986 LAPS(ph)EDELTCFSK ddPTM_A459_Selumetinib_30min_R2 2 LAPSEDELTCFSK 13 0 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 LAPS(1)EDELTCFSK;LAPS(1)EDELTCFSK 188.92 0.00015217 9633000.0 38428.0 32134.0 38090.0 42839.0 41260.0 31202.0 35039.0 35562.0 31481.1 41239.0 True False 36292.32559947236 34598.57447290467 35639.330869256315 37004.254298603046 36076.54993091999 35499.79227644495 36668.3829284613 35665.47953239398 37778.199655427576 40048.32291821019 0.9062133681250867 0.8639206826104697 0.8899081977051008 0.9239901100022595 0.9008254853667238 0.8864239421197584 0.9156034574368652 0.8905611254991328 0.9433153975656149 1.0 15.28945420849452 -8.553311038682663 2.468165069966162 0.9999346926272528 0.8969124968701397 0.8043523400161614 0.015919324558296782 0.12997002458323773 1.895582859008231 0.015764257548838877 0.004282590873798913 2.7969774263836676e-09 8.553311038682663 -0.10302219575711302 LAPVPS(ph)PEPQKPAPVS(ph)PESVK ddPTM_A459_Selumetinib_30min_R1 4 LAPVPSPEPQKPAPVSPESVK 21 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 2 LAPVPS(1)PEPQKPAPVS(0.971)PES(0.029)VK;LAPVPS(1)PEPQKPAPVS(0.927)PES(0.073)VK;LAPVPS(1)PEPQKPAPVS(0.954)PES(0.046)VK;LAPVPS(1)PEPQKPAPVS(0.933)PES(0.067)VK 106.88 0.0002682 259063600.0 15465.5 18236.199999999997 20790.899999999998 20758.3 16709.5 16214.4 15975.0 15746.6 10005.16 15025.900000000001 True False 15825.816059375506 16101.097226220625 17967.609976238924 17133.252586550934 15198.128675301827 16051.297857497282 14769.99288845371 15328.94901583462 16978.02577202591 16954.620629660345 0.933422009554722 0.9496583602733895 1.0597470960103028 1.0105358863989025 0.8964003977012781 0.9467211451146955 0.8711485329618726 0.9041163085075592 1.0013804580401298 1.0 14.049390883061664 -6.254100918328644 24.964694964783035 0.9290643253834366 0.9906782520260863 0.19037437058382234 0.05073713881968249 848.8551278520372 2887718.8109025857 0.015511476556482875 0.019602938691470694 5.570562890281606e-07 6.254100918328644 0.06161392664264964 LAPVPS(ph)PEPQKPAPVS(ph)PESVK ddPTM_A459_Selumetinib_30min_R2 4 LAPVPSPEPQKPAPVSPESVK 21 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 2 LAPVPS(1)PEPQKPAPVS(0.949)PES(0.051)VK;LAPVPS(1)PEPQKPAPVS(0.995)PES(0.005)VK;LAPVPS(1)PEPQKPAPVS(0.985)PES(0.015)VK;LAPVPS(1)PEPQKPAPVS(0.945)PES(0.055)VK 94.73 0.00086252 33100900.0 235220.0 222244.0 228269.0 240364.0 218326.0 177306.0 198510.0 192178.0 155683.0 214153.0 True False 222147.41406026587 239289.4001729081 213582.42106049557 207626.00854897217 190897.9360207957 201728.29207638427 207741.10834010263 192737.20616321944 186823.9501464665 207969.84645368377 1.0681712654422695 1.150596609332014 1.0269874441055653 0.9983466934722761 0.9179116072642286 0.9699881762489567 0.998900138085008 0.9267555342747404 0.8983222968723661 1.0 17.666014841623912 -5.633300446825916 2.064114148729865 0.9526557022561287 1.1093005951778299 0.7122242123919369 0.03838784888057091 0.1644479107040198 1.4088964187435025 0.011320449375470104 0.02525460144554699 2.3264812309058784e-06 5.633300446825916 0.15664489292170114 LAPVPS(ph)PEPQKPAPVSPESVK ddPTM_A459_Selumetinib_30min_R1 2 LAPVPSPEPQKPAPVSPESVK 21 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 LAPVPS(1)PEPQKPAPVSPESVK;LAPVPS(0.998)PEPQKPAPVS(0.002)PESVK 111.77 5.4571e-05 212638000.0 10499.0 11902.6 13033.9 13244.4 10857.3 9207.6 10767.3 10531.8 6381.3 9297.8 True False 10743.606272502246 10509.03805863138 11263.967970087888 10931.514168179237 9875.259132012008 9114.979903831896 9955.113892197034 10252.46245189228 10828.600028288298 10491.263198241442 1.0240526874116647 1.0016942535950215 1.0736522149187875 1.0419635807070011 0.941284089952801 0.8688162456318663 0.948895638598193 0.977238132164181 1.0321540717902684 1.0 13.356900775302643 -6.258201291165291 24.77979716755828 0.9550057264652992 1.0356739094423102 0.4052646045425359 0.043470055522039364 260.6152896528327 1994380.0330085806 0.014158351032974198 0.01752243977617701 5.51821616178556e-07 6.258201291165291 0.08066818297701095 LAPVPS(ph)PEPQKPAPVSPESVK ddPTM_A459_Selumetinib_30min_R2 2 LAPVPSPEPQKPAPVSPESVK 21 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 LAPVPS(1)PEPQKPAPVSPESVK;LAPVPS(1)PEPQKPAPVSPESVK 93.812 0.00026884 102077000.0 151802.0 131280.0 153628.0 162525.0 144321.0 110066.0 121836.0 129978.0 96452.0 131710.0 True False 143365.45255155372 141348.7538682677 143743.74173751907 140388.81462873687 126190.10573388997 125226.59242033167 127501.61541345387 130356.21446098383 115745.09509405002 127907.19007632238 1.1208553050536672 1.1050884143723643 1.1238128337566247 1.09758344738061 0.9865755448039487 0.9790426350982209 0.9968291488334119 1.0191468859819381 0.9049146887284818 1.0 16.96473783948432 -6.233213885431487 3.925657660641541 0.9818234368639628 1.114704469158374 0.8357081601150674 0.02848675476525376 0.08551561282848201 2.964553811249646 0.008557657664989771 0.010803302569528238 5.845021521307702e-07 6.233213885431487 0.13288103229441128 LAPWQAS(ph)PPHPCR ddPTM_A459_Selumetinib_30min_R2 3 LAPWQASPPHPCR 13 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 LAPWQAS(1)PPHPCR;LAPWQAS(1)PPHPCR;LAPWQAS(1)PPHPCR 103.6 0.0055255 14670900.0 41886.0 52301.0 54111.0 57492.0 64288.0 47286.0 49948.0 60762.0 43848.0 47519.0 True False 39558.143802943145 56312.31852577915 50629.55717160222 49661.49042076817 56211.56669798793 53799.21728042997 52270.68097008436 60938.8073603094 52618.825215484496 46147.003000810655 0.8572202143278564 1.2202811637581301 1.0971364092856217 1.076158519327805 1.218097883778075 1.165822562290446 1.1326993644455337 1.3205366198805781 1.1402436083348717 1.0 15.493949335193689 -4.754443058541806 24.998066006424185 1.160105621357592 0.85721969254668 0.5245661365816785 0.08399206134177686 187.85349530535902 671147.6401758173 0.020308250424584846 0.19786243325805752 1.7601794302914572e-05 4.754443058541806 -0.30288592881091203 LAQANGWGVMVSHR ddPTM_A459_Selumetinib_30min_R2 1 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 0 122.78 0.002422 3365700.0 13385.0 6199.4 11596.0 13010.0 14698.0 10266.0 9453.5 8997.5 10141.0 11447.0 False True 12641.115284400372 6674.874045787179 10849.925984770183 11238.015556498189 12851.505838212837 11680.048314530599 9893.106481754872 9023.681235383685 12169.483363214482 11116.495367122192 1.1371493323145125 0.6004476973497046 0.9760203757075808 1.010931519814725 1.1560753109493536 1.0506951992329483 0.8899483294901037 0.8117379567369631 1.0947230184799586 1.0 13.440414409212 -5.492018953737357 24.979410144000173 0.9976055408763765 0.848657390262845 0.10451253253630044 0.15116837822117854 1275.7868395564058 1032681.8027571946 0.03891968460201508 0.08085900579193515 3.2209282185563452e-06 5.492018953737357 -0.1489481506135315 LAQGHTTVDELAR ddPTM_A459_Selumetinib_30min_R2 2 LAQGHTTVDELAR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 133.98 0.0017820999999999996 7886200.0 18250.6 21543.0 31501.0 34459.0 32781.0 19188.0 20302.9 16533.2 22168.5 26487.0 False True 17236.3047149404 23195.278828337123 29474.259955695532 29765.6247549094 28662.757714141706 21830.972828678474 21247.025079433126 16581.308874781393 26602.81943964305 25722.251488509264 0.67009315738322 0.901759274016079 1.145866253926581 1.157193598243389 1.1143176065651188 0.8487193602951469 0.8260173138002586 0.6446289852266103 1.0342337042901224 1.0 14.65072930795184 -6.792495306611212 22.04496949691645 0.8457147082560115 1.0095836825872408 0.11616018723152843 0.16684921346359866 102.97056019600923 73091.36460249411 0.06201441892588913 0.05470442944211059 1.6125184536128895e-07 6.792495306611212 0.16386897433122938 LAQSNGWGVMVSHR ddPTM_A459_Selumetinib_30min_R1 2 LAQSNGWGVMVSHR 14 0 P13929-3;P13929-2;P13929 P13929-3 ENO3 Beta-enolase 0 ; 134.02 0.00095337 76712000.0 7233.200000000001 7596.5 8511.7 8622.2 7621.1 6569.9 6214.0 7496.900000000001 4242.5 5930.799999999999 False True 7401.719486642843 6707.098248482961 7355.857891421385 7116.4946287393195 6931.772850614485 6503.812770991921 5745.272977079897 7298.057858636816 7199.212640059722 6692.075950884113 1.1060423612892463 1.0022447888680737 1.0991892419346463 1.0634210790448568 1.0358180184280044 0.9718677460814951 0.8585187943542197 1.0905521563413583 1.07578166967884 1.0 12.708238103819294 -6.536195011024862 4.3144867807728176 0.996371044596794 1.064170498022129 0.19801469632130653 0.06453907826885015 0.3753160159602903 16.88521808942073 0.02285146686483203 0.023878882148830615 2.9094104136724485e-07 6.536195011024862 0.06779945342533489 LAS(ph)PELER ddPTM_A459_Selumetinib_30min_R1 4 LASPELER 8 0 P05412;P17535 P05412;P17535 JUN;JUND Transcription factor AP-1;Transcription factor jun-D 1 LAS(1)PELER;LAS(1)PELER;LAS(1)PELER;LAS(1)PELER 117.53 0.0088168 248050000.0 26432.800000000003 25001.199999999997 29785.1 28549.4 26935.0 22276.300000000003 23729.1 23098.4 14954.599999999999 17880.8 True False 27048.63281072458 22074.047881257455 25740.447017843067 23563.783228611086 24498.73400576048 22052.2206472621 21939.194882591986 22485.755397822657 25376.86395923088 20175.974853741263 1.3406357316959536 1.0940759017234911 1.2757969418796127 1.167912995502253 1.2142528023233357 1.0929940588805265 1.0873920611832923 1.1144817319026885 1.2577763475218253 1.0 14.300350762231204 -6.753629722767607 24.770982423131816 1.1162378979226035 1.211989407025436 0.28734744126018796 0.08449411490964256 230.1332543073385 729945.0753450879 0.026739379748650222 0.02626185744484921 1.763478938677274e-07 6.753629722767607 0.09575150910283248 LAS(ph)PELER ddPTM_A459_Selumetinib_30min_R2 4 LASPELER 8 0 P05412;P17535 P05412;P17535 JUN;JUND Transcription factor AP-1;Transcription factor jun-D 1 LAS(1)PELER;LAS(1)PELER;LAS(1)PELER;LAS(1)PELER 117.53 0.0088168 201109700.0 300361.0 273372.0 287352.0 296663.0 304132.0 237524.0 228777.0 239442.0 237714.0 299265.0 True False 283668.13806034933 294338.75337047613 268864.0851652024 256256.98762777977 265924.2191854227 270240.7749718067 239415.58381302518 240138.73657824294 285263.4422841107 290624.44186615053 0.9760642850231951 1.0127804512259029 0.9251255105688253 0.8817461669166871 0.9150098232546328 0.9298625168500737 0.8237971392760214 0.8262854116338941 0.9815535143994912 1.0 18.14879651490326 -5.406088541603141 4.131866896208711 0.8989356432556621 0.9937182189275331 0.2635327088159086 0.05499555155183365 0.262179006621461 7.477923557907907 0.014570007961833817 0.032144929487329416 3.925648932396305e-06 5.406088541603141 0.09478257567187098 LAS(ph)PMKPVPGTPPSSK ddPTM_A459_Selumetinib_30min_R1 2 LASPMKPVPGTPPSSK 16 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 LAS(1)PMKPVPGTPPSSK;LAS(1)PMKPVPGTPPSSK 157.83 0.00034829 11543000.0 2947.9 3424.7 2661.45 3062.1 2413.8199999999997 2427.3999999999996 2856.5 2630.7 1280.52 2288.2 True False 3016.58033438512 3023.7345319001647 2300.0397082983927 2527.3617177359247 2195.490407194534 2402.9825599028572 2641.031905218656 2560.925290282099 2172.9489145195694 2581.912758955458 1.1683509924655673 1.171121882957599 0.8908278176017458 0.9788718495501753 0.85033485332895 0.9306985883113306 1.0228974220984584 0.9918713486346264 0.8416043133071083 1.0 11.334224538464163 -5.254211742523404 24.803967135732474 0.9391425933611934 1.169736477497515 0.7105222835671896 0.05906540807991771 260.3413543073947 893438.4564614096 0.015181337021623059 0.03841212377687393 5.569141563485268e-06 5.254211742523404 0.23059388413632154 LAS(ph)PMKPVPGTPPSSK ddPTM_A459_Selumetinib_30min_R2 2 LASPMKPVPGTPPSSK 16 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 LAS(0.999)PMKPVPGTPPSSK;LAS(0.997)PMKPVPGT(0.003)PPSSK 148.33 0.0034270000000000004 40923000.0 295808.0 245980.0 306918.0 301727.0 292404.0 257426.0 293182.0 305507.0 206648.0 280397.0 True False 279368.17557324667 264845.8750496385 287171.23002705234 260631.2620918933 255669.59539507297 292884.09481943864 306815.5439291118 306395.9747905937 247983.37422754642 272301.2100511024 1.0259527510759796 0.9726209993702755 1.0546087179456871 0.9571432387060674 0.9389219950476599 1.075588664348842 1.1267505710735994 1.1252097437726878 0.9106950871830783 1.0 18.05484386787561 -6.7816794087321774 24.997961803292686 1.0604182978941825 0.9906731032414756 0.1451778879288218 0.06660044006181386 403.5188519961945 498372.8270566198 0.023626358110588972 0.02086099385746417 1.6531817079250963e-07 6.7816794087321774 -0.0697451946527069 LAS(ph)PQPSYAADANDSK ddPTM_A459_Selumetinib_30min_R2 2 LASPQPSYAADANDSK 16 0 Q5TGY3 Q5TGY3 AHDC1 AT-hook DNA-binding motif-containing protein 1 1 LAS(1)PQPSYAADANDSK;LAS(0.991)PQPS(0.009)YAADANDSK 184.32 1.0290999999999999e-13 8038300.0 63160.0 46426.0 53222.0 59516.0 56729.0 49160.0 54458.0 65612.0 54077.0 49234.0 True False 59649.82004951268 49986.72491688159 49797.754463732206 51409.81812917344 49602.19585630533 55931.343769951694 56990.40490647982 65802.92005734863 64893.91103762441 47812.486494705496 1.2475782880716315 1.0454742804981887 1.0415219561786762 1.0752383299468498 1.0374318403582297 1.1698062131979945 1.1919565177349778 1.376270612168127 1.35725865344423 1.0 15.5450998147331 -7.212150873519805 2.2581672072636287 1.271431765199987 1.0853935241409642 0.2355431438706146 0.11369740869799587 0.3544753102163481 3.5401887713850586 0.052038508979064424 0.035276233997543524 6.135488218177619e-08 7.212150873519805 -0.18603824105902267 LAS(ph)PSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICR ddPTM_A459_Selumetinib_30min_R1 4 LASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICR 38 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 LAS(0.627)PS(0.161)GS(0.196)T(0.013)S(0.001)S(0.001)GLEVVAPEGTSAPGGGPGTLDDSATICR;LAS(0.943)PS(0.024)GS(0.03)T(0.003)SSGLEVVAPEGTSAPGGGPGTLDDSATICR;LAS(0.585)PS(0.132)GS(0.145)T(0.058)S(0.058)S(0.022)GLEVVAPEGTSAPGGGPGTLDDSATICR;LAS(0.887)PS(0.018)GS(0.09)T(0.004)S(0.001)SGLEVVAPEGTSAPGGGPGTLDDSATICR 184.2 1.649099999999999e-51 170989000.0 8832.05 9371.02 8933.17 8373.029999999999 8370.55 7353.32 8908.96 8472.26 4888.49 7736.59 True False 9037.819580822308 8273.856621931 7720.094580390372 6910.837491739139 7613.435230440634 7279.352277080361 8236.949974555155 8247.548143021031 8295.410488816866 8729.656687268249 1.035300688743407 0.9477871717450229 0.8843525990718203 0.7916505470161543 0.8721345527303993 0.8338646682059008 0.943559439922571 0.9447734817624217 0.9502562112110653 1.0 13.091709202512824 -10.088022528595834 7.236745467437167 1.0000002168961006 0.9067397902642611 0.13679325984344337 0.06569912133876932 0.0 0.0 0.06920257904891743 0.016784090763755432 8.165400130560221e-11 10.088022528595834 -0.09326042663183953 LAS(ph)PVAPGALTTPGGSAPAQVVHTQPPPR ddPTM_A459_Selumetinib_30min_R2 1 LASPVAPGALTTPGGSAPAQVVHTQPPPR 29 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4 Q96L91-3 EP400 E1A-binding protein p400 1 LAS(0.995)PVAPGALT(0.004)T(0.001)PGGSAPAQVVHTQPPPR 91.432 1.0593e-06 3418900.0 15968.0 18336.0 19003.0 20548.0 19170.0 13996.0 17530.0 20816.0 17010.0 21033.0 True False 15080.562484968626 19742.31224046743 17780.367668902007 17749.326952722895 16761.69321802559 15923.821956961847 18345.179735036014 20876.5711137257 20412.475299110367 20425.722639703068 0.7383123109512592 0.9665416782901359 0.8704890388720408 0.8689693513326253 0.820616901232399 0.7795965037736032 0.8981410380740733 1.022072583769755 0.9993514383394715 1.0 14.31809949979427 -7.634887043259951 4.147717730305197 1.0076176650933497 0.8475039970297261 0.6237164050215032 0.05749483131263012 0.15073783875543276 4.666111068619424 0.02925199795241016 0.016000219100530667 2.3179974653403745e-08 7.634887043259951 -0.1601136680636236 LAS(ph)SVLR ddPTM_A459_Selumetinib_30min_R1 5 LASSVLR 7 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 LAS(0.5)S(0.5)VLR;LAS(0.772)S(0.228)VLR;LAS(0.5)S(0.5)VLR;LAS(0.5)S(0.5)VLR;LAS(0.96)S(0.04)VLR 126.24 0.005767100000000001 25156600.0 11408.5 15005.499999999998 13459.4 15464.0 14855.2 11645.0 13347.699999999999 13092.600000000002 7085.08 10186.699999999999 True False 11674.295852923316 13248.649084132314 11631.687407192096 12763.502695231477 13511.549782898579 11527.861872814026 12340.872242705072 12745.34171724159 12022.863286230837 11494.26217186066 1.0156629175819045 1.1526315378960648 1.0119559858020177 1.1104238362056913 1.1755038801861055 1.0029231716182376 1.0736550165801 1.1088438323987182 1.0459882597479162 1.0 13.488626240545836 -8.541101194235988 5.24463625442834 1.0000287750100025 1.08258405685649 0.17395900993801539 0.05559140403319108 0.26788323120910557 33.63441145679006 0.05147615521235912 0.013374981606095931 2.876728035014659e-09 8.541101194235988 0.08255528184648742 LAS(ph)SVLR ddPTM_A459_Selumetinib_30min_R2 3 LASSVLR 7 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 LAS(0.873)S(0.127)VLR;LAS(0.5)S(0.5)VLR;LAS(0.957)S(0.043)VLR 112.41 0.014575 15873800.0 87285.0 86854.0 102596.0 102235.0 97359.0 70792.0 66420.0 82197.0 67234.0 100701.0 True False 82434.04912953943 93515.42252037274 95995.08505807855 88310.41663478824 85127.89201949676 80542.95541420707 69508.6616087332 82436.17966155405 80682.67867491982 97793.50047738034 0.842939957432104 0.9562539643624157 0.9816100721364631 0.9030295081339732 0.8704861939080182 0.823602335748649 0.7107697471654628 0.842961743460871 0.8250310938975106 1.0 16.57745096394327 -6.404758137859731 2.3831459797019154 0.8235617269730552 0.9295926675750505 0.18779392440034748 0.07462171369657268 0.38965839170819905 4.340654957468364 0.02523654152240839 0.029206895782985083 3.9376930774413166e-07 6.404758137859731 0.10603094060199536 LAS(ph)TSDIEEK ddPTM_A459_Selumetinib_30min_R1 2 LASTSDIEEK 10 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 LAS(0.898)T(0.026)S(0.075)DIEEK;LAS(0.39)T(0.39)S(0.22)DIEEK 172.13 0.00015371 21608900.0 3526.2 3763.5 2935.1 3218.9 3485.3 4724.7 9490.400000000001 11914.8 9234.4 3208.0 True False 3608.353599209201 3322.8676703963165 2536.5295413502463 2656.779541236461 3170.055230379694 4677.173807684366 8774.531487235123 11598.78079927516 15670.102346108999 3619.778048566168 0.9968438812535779 0.9179755293870958 0.7007417325918621 0.7339620014240484 0.875759559798255 1.2921161863880144 2.4240523505884033 3.204279556275435 4.32902297761491 1.0 11.821685523945789 -7.293715508165482 2.223474669489503 3.0596363165952467 0.8417634287786961 0.5740938186910259 0.7734177750999877 0.20256058411045647 1.959450269612086 0.36605389573220043 0.23220699317932586 5.084924299204946e-08 7.293715508165482 -2.217872887816551 LAS(ph)YLDR ddPTM_A459_Selumetinib_30min_R1 4 LASYLDR 7 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 LAS(1)YLDR;LAS(1)YLDR;LAS(1)YLDR;LAS(1)YLDR 106.42 0.017128 87123000.0 13329.4 14848.599999999999 17549.7 19538.0 21135.7 13651.0 20840.8 25474.1 7344.6 15465.8 True False 13639.949085502565 13110.11900907313 15166.547133601716 16126.055073682925 19223.979666810923 13513.683334116293 19268.761676975664 24798.444116461505 12463.24977163998 17450.986079649214 0.7816148052177431 0.7512537657893004 0.869093990699383 0.9240770120428105 1.1015984758150326 0.774379354406541 1.104164635111725 1.4210339750015997 0.7141859901071278 1.0 14.091020938736598 -5.722804469236736 0.7982347054178797 1.054142058716505 0.7204099877987287 0.22119455617162453 0.18348792201552933 1.330245444677874 1.467176797891519 0.08501303114930506 0.3147664205631995 1.8931957931819563e-06 5.722804469236736 -0.33373207091777624 LAS(ph)YLDR ddPTM_A459_Selumetinib_30min_R2 4 LASYLDR 7 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 LAS(1)YLDR;LAS(1)YLDR;LAS(0.992)Y(0.008)LDR;LAS(0.997)Y(0.003)LDR 106.42 0.017128 37960900.0 110183.0 104057.0 123877.0 134491.0 134733.0 78769.0 117675.0 119681.0 91090.0 113626.0 True False 104059.46995749627 112037.8373040094 115906.8886870795 116173.09379008412 117806.63601169756 89618.71475621092 123147.12066858896 120029.25189574371 109310.54526725254 110345.32214419718 0.9430347198725227 1.0153383498903603 1.0504014708989164 1.0528139438323567 1.0676178538656136 0.8121659624057183 1.116015779152492 1.0877602200380707 0.9906223765825577 1.0 16.751665945355512 -4.769774699287014 4.564811515524926 1.0244010156331367 0.9370691643320979 0.08117579713732936 0.07908488889480805 0.5254414907724339 24.71824734721794 0.019933182895358174 0.14874237522984293 1.699124885782303e-05 4.769774699287014 -0.08733185130103882 LASDDRPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 LASDDRPSPPR 11 1 P98175-5;P98175-2;P98175;P98175-4;P98175-3 P98175-5 RBM10 RNA-binding protein 10 1 LASDDRPS(1)PPR;LASDDRPS(1)PPR;LASDDRPS(1)PPR;LASDDRPS(1)PPR 165.78 0.0028735 894250700.0 16956.5 17076.499999999996 19165.0 20239.600000000002 19418.1 16141.1 16971.6 16284.8 9679.7 13962.7 True False 17351.55345839455 15077.175441350517 16562.498265809496 16705.133804346046 17661.736283543996 15978.735188946202 15691.418548086456 15852.874203514637 16425.743922683807 15754.948553215354 1.1013398996376507 0.9569803030726803 1.0512568930242132 1.0603102731767902 1.1210278614295757 1.0142042124082453 0.9959676158310315 1.0062155487190911 1.0425768048180362 1.0 13.943517422883495 -10.870411094839893 7.487542598562244 0.9999995191691916 1.0369294395298108 0.058007412272298886 0.04640538593215814 3.793641830236762e-07 3.305657312482846e-08 0.04575775832679635 0.011097741982164292 1.3476865843144891e-11 10.870411094839893 0.03692992036061915 LASDDRPS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 5 LASDDRPSPPR 11 1 P98175-5;P98175-2;P98175;P98175-4;P98175-3 P98175-5 RBM10 RNA-binding protein 10 1 LASDDRPS(1)PPR;LAS(0.002)DDRPS(0.998)PPR;LASDDRPS(1)PPR;LAS(0.003)DDRPS(0.997)PPR;LASDDRPS(1)PPR 192.4 9.5597e-05 564420000.0 1168925.0 1105260.0 1346480.0 1365849.0 1371194.0 1047462.0 1051210.0 1186071.0 889710.0 1227509.0 True False 1103960.8280775286 1190029.8880289625 1259848.9427365768 1179818.0099790518 1198932.3510901073 1191740.3825866804 1100093.3479330982 1189522.2702453749 1067676.8605744578 1192067.625718601 0.9260890944941483 0.998290585495592 1.0568602951339408 0.9897240597133363 1.005758671088285 0.9997254827453909 0.9228447482330887 0.9978647558088898 0.8956512512709519 1.0 20.18503465119928 -7.230445849956589 22.90453065802521 0.9539122552749472 0.9990899381140349 0.1952128533206584 0.04149121574785863 375.12416810159056 277220.4546154658 0.015463753862724987 0.011976057742469808 5.882394542557611e-08 7.230445849956589 0.04517768283908774 LASDS(ph)DAESDSR ddPTM_A459_Selumetinib_30min_R1 1 LASDSDAESDSR 12 0 A0A0A0MRB5;Q8WXG6-6;Q8WXG6-8;Q8WXG6-5;Q8WXG6-4;Q8WXG6-7;Q8WXG6-3;Q8WXG6-2;Q8WXG6 A0A0A0MRB5 MADD MAP kinase-activating death domain protein 1 LAS(0.007)DS(0.989)DAES(0.004)DSR 179.59 8.8034e-09 0.0 1381.3 1431.0 1339.0 1508.5 1082.1 1009.8 1187.0 1060.5 713.24 1109.5 True False 1413.4816024580773 1263.4578547461479 1157.1711546005183 1245.0687930520367 984.2242460602722 999.6423288250407 1097.4636343408167 1032.3720950105173 1210.3161870114773 1251.9151324451886 1.1290554493876304 1.0092200517445735 0.9243207663289281 0.9945313071024391 0.7861748936111398 0.7984904910228067 0.8766278207671284 0.8246342489639302 0.9667717528484043 1.0 10.28992104968788 -4.780850209470002 0.9203987168963392 0.8713601600403652 1.265710465938058 0.517015410765507 0.07231334634988329 1.656758302200122 1.0960140285598534 0.025185061788304552 0.6603054989127657 1.6563411460360345e-05 4.780850209470002 0.3943503058976928 LASLGDTAS(ph)PLVK ddPTM_A459_Selumetinib_30min_R2 2 LASLGDTASPLVK 13 0 Q6P4F7-3;Q6P4F7 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 LASLGDT(0.032)AS(0.968)PLVK;LAS(0.001)LGDT(0.092)AS(0.907)PLVK 148.85 0.0005352 12875100.0 86214.0 81046.0 83337.0 93432.0 87304.0 77393.0 84284.0 78028.0 61413.0 81707.0 True False 81422.57102198689 87261.96759603625 77975.18815046518 80706.40042081011 76336.0910123373 88053.18324629524 88203.37300557757 78255.04856176926 73697.31602259063 79347.90660971882 1.026146429073076 1.0997387495708437 0.9827000040970773 1.0171207265463624 0.962042910442547 1.1097102243590906 1.1116030248840125 0.9862270084411313 0.9287871497994116 1.0 16.2759045413167 -7.984962134162542 24.570794857755633 0.9620980565597449 1.0427260453926879 0.30284346639729 0.05105972065027697 225.4570242121361 368380.4037867814 0.029236825623889812 0.01403575363750081 1.0352324239482515e-08 7.984962134162542 0.08062798883294298 LASPSGS(ph)TSSGLEVVAPEGTSAPGGGPGTLDDSATICR ddPTM_A459_Selumetinib_30min_R2 3 LASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICR 38 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 LAS(0.213)PS(0.287)GS(0.435)T(0.046)S(0.015)S(0.004)GLEVVAPEGTSAPGGGPGTLDDSATICR;LAS(0.129)PS(0.175)GS(0.614)T(0.05)S(0.016)S(0.016)GLEVVAPEGTSAPGGGPGTLDDSATICR;LAS(0.095)PS(0.058)GS(0.263)T(0.263)S(0.263)S(0.058)GLEVVAPEGTSAPGGGPGTLDDSATICR 111.38 4.907500000000001e-19 185948000.0 48306.4 44904.5 42092.9 48567.0 59591.0 36199.3 60108.2 45729.0 32288.4 62033.7 True False 45621.72367384074 48348.53075927517 39384.688641284316 41952.09081725192 52104.64582970075 41185.42499047221 62903.350402138734 45862.06381915652 38746.982213274234 60242.62589809102 0.7572997191559409 0.8025634679514734 0.6537677940518251 0.6963854943544435 0.8649132578955502 0.6836591927473948 1.0441668082090032 0.761289255497241 0.6431821594035471 1.0 15.878497036139429 -6.25790390872716 24.698115598286325 0.8240373642553025 0.7275986192302015 0.14826736737878188 0.12262534806366104 584.2319433025116 4081323.809657933 0.036590423423791325 0.045333341498435986 5.52199604528874e-07 6.25790390872716 -0.09643874502510097 LASS(ph)VLR ddPTM_A459_Selumetinib_30min_R2 3 LASSVLR 7 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 LAS(0.222)S(0.778)VLR;LAS(0.222)S(0.778)VLR;LAS(0.232)S(0.768)VLR 95.815 0.023547 15620300.0 77814.0 77729.0 90479.0 86022.0 91967.0 64197.0 70045.0 62894.0 56198.0 86562.0 True False 73489.40939412257 83690.56436187252 84657.67964608654 74305.65520377297 80413.28326458836 73039.55402765631 73302.23129153435 63077.01112733779 67439.17030331596 84062.73014491421 0.8742210640486636 0.9955727611701389 1.0070774468084336 0.8839310247915908 0.95658662436927 0.8688696393960171 0.8719944161362588 0.7503564423686987 0.80224815666894 1.0 16.359178691887152 -6.933922622627887 1.8198844375258654 0.833609107285291 0.9492332733627391 0.23034043275471416 0.07256451844503241 0.41252257238382023 2.7818032072684575 0.03170684944098619 0.02550235251899947 1.164333457875771e-07 6.933922622627887 0.11562416607744808 LAST(ph)SDIEEK ddPTM_A459_Selumetinib_30min_R1 1 LASTSDIEEK 10 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 LAS(0.033)T(0.484)S(0.484)DIEEK 187.85 0.00043568 22325000.0 2207.9 2678.8 2069.8 2052.4 1876.8 2812.7 5783.6 8451.7 5836.4 2301.5 True False 2259.3397741744657 2365.164850659667 1788.732528597574 1693.9868683195216 1707.0437713759518 2784.4067917272673 5347.338395596928 8227.533461009321 9903.944526209672 2596.919943508428 0.8700074793688508 0.9107577060940659 0.6887900156756483 0.6523061569741547 0.6573339989332682 1.0721958521237838 2.059107909338436 3.168189100929295 3.813727316071779 1.0 11.342585824714755 -7.371495719431516 2.484870013818548 2.8519451120023507 0.7660378165790014 0.606987780624143 0.6784360247068942 0.17637639477819184 2.122574482589735 0.3229907126854693 0.1971466539598367 4.2511289685532205e-08 7.371495719431516 -2.0859072954233495 LASTLVHLGEYQAAVDGAR ddPTM_A459_Selumetinib_30min_R1 1 LASTLVHLGEYQAAVDGAR 19 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 127.88 0.0012752 0.0 1724.7 1930.3 2097.3 2099.4 1687.8 1580.6 1423.8 1747.0 1372.2 1834.5 False True 1764.8821543179934 1704.2995786278768 1812.4981796442626 1732.7792006187913 1535.1387880052928 1564.7005990699752 1316.4016196920438 1700.6638849442472 2328.5231784772996 2069.975944543217 0.8526099827249206 0.8233426978321556 0.8756131608303438 0.8371011292119943 0.7416215594447659 0.7559027935540859 0.6359502018186666 0.8215863036609027 1.1249034968815237 1.0 11.015398286739412 -8.20116865018029 6.174123160190388 1.0614760892825277 0.7888528992386276 0.6983472659234242 0.07092040105269423 0.11711451762525145 9.226812163744807 0.054101619961415 0.019637342701124896 6.292617733045471e-09 8.20116865018029 -0.2726231900439001 LASTNS(ph)SVLGADLPSSMK ddPTM_A459_Selumetinib_30min_R2 1 LASTNSSVLGADLPSSMK 18 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;H0YA99;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 LAS(0.002)T(0.013)NS(0.635)S(0.35)VLGADLPSSMK 103.67 0.0020013 2890400.0 14639.0 15053.0 14754.0 14693.0 16311.0 14407.0 13379.0 12609.0 11900.0 13709.0 True False 13825.422984560111 16207.516696976234 13804.743702940596 12691.78805316125 14261.866357809879 16391.433476275317 14001.150009985562 12645.690102467686 14280.332513780912 13313.185549740383 1.0384759479920054 1.2174033507173865 1.0369226547142805 0.9533246574039336 1.0712587385284356 1.2312179842333049 1.0516754204074468 0.9498620788556715 1.0726457961865774 1.0 13.700568197000262 -7.524703718614755 24.977395526214156 1.0069060939301504 1.0919838658360606 0.1722512498581562 0.08263797576349059 112.69425933182166 1542301.6415367879 0.04040731879807773 0.023538600235967124 2.9874199809305836e-08 7.524703718614755 0.08507777190591015 LASTNSS(ph)VLGADLPSSMK ddPTM_A459_Selumetinib_30min_R2 1 LASTNSSVLGADLPSSMK 18 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;H0YA99;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 LASTNS(0.08)S(0.92)VLGADLPSSMK 244.18 5.167499999999998e-79 0.0 15359.0 12988.0 12083.0 17887.0 12836.0 11493.0 14150.0 12486.0 9207.9 15999.0 True False 14505.40826694847 13984.137836997761 11305.592934975692 15450.75974320392 11223.426924704034 13076.05642693358 14808.003037693083 12522.332192831427 11049.737290222121 15537.06729960584 0.9336001439162498 0.9000500266451523 0.7276529551534158 0.9944450548653986 0.7223645690836881 0.8416038995509343 0.9530758123232655 0.8059649836973485 0.7111855202237839 1.0 13.923426592973284 -5.015795559652913 23.698892316088248 0.8404678551370084 0.9252127254605211 0.07569497889209631 0.10319478319257089 775.7658471146209 1163945.642073557 0.024918030226203328 0.07095334351092454 9.642828445550427e-06 5.015795559652913 0.08474487032351274 LASTS(ph)DIEEK ddPTM_A459_Selumetinib_30min_R1 1 LASTSDIEEK 10 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 LAS(0.058)T(0.225)S(0.718)DIEEK 164.48 0.00037467 3700500.0 1358.8 1379.1 1379.8 1404.6 1547.6 1920.8 3017.5 4091.0 2712.5 1373.1 True False 1390.457396235456 1217.6343308738033 1192.4307386988753 1159.3129776074845 1407.6198532509725 1901.478495946859 2789.8875455968127 3982.4933905591965 4602.914386838417 1549.350760126624 0.8974451957682054 0.7858997214899804 0.769632525691872 0.7482572748812136 0.9085223885235205 1.2272743815554437 1.80068169028994 2.5704272351044115 2.9708665754049357 1.0 10.597448079925325 -7.265101816515322 1.973147097473115 2.31492955738335 0.8170509732729756 0.6071307331275816 0.4802624217064862 0.20360103468020346 1.5476023882387173 0.2358077081066803 0.14921402647147158 5.4312298616611106e-08 7.265101816515322 -1.4978785841103743 LASVPAGGAVAVSAAPGS(ph)AAPAAGSAPAAAEEK ddPTM_A459_Selumetinib_30min_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 LASVPAGGAVAVS(0.001)AAPGS(0.999)AAPAAGSAPAAAEEK 176.51 1.7077999999999996e-41 6137100.0 2288.3 2974.0 2623.1 2961.5 2323.6 2774.4 3123.1 2954.9 1500.3 2246.8 True False 2341.612937743297 2625.8026974249105 2266.8974276569215 2444.3296192400426 2113.4307902648984 2746.4920549536487 2887.522052577763 2876.5264531320863 2545.8995224234745 2535.1986656853073 0.9236408055265047 1.0357384346110452 0.8941695411645937 0.964157031290997 0.8336351777361014 1.083343917827136 1.1389726934071325 1.1346355187334056 1.004220914472308 1.0 11.307883090182116 -6.792211990142025 24.36008345112458 1.0848206245888314 0.9360049164829287 0.5392795169662028 0.06498381073180307 113.76226542746488 90055.04836832419 0.022593509137185615 0.019928151258326525 1.6135707397979886e-07 6.792211990142025 -0.14881570810590272 LASVPAGGAVAVSAAPGS(ph)AAPAAGSAPAAAEEK ddPTM_A459_Selumetinib_30min_R2 2 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 LASVPAGGAVAVS(0.005)AAPGS(0.97)AAPAAGS(0.025)APAAAEEK;LASVPAGGAVAVSAAPGS(0.999)AAPAAGS(0.001)APAAAEEK 146.58 4.229999999999999e-27 15562200.0 85715.0 73612.0 81044.0 87130.0 76936.0 67747.0 66539.0 69599.0 58852.0 76692.0 True False 80951.30344433153 79257.80370011395 75829.71727403541 75262.74369236642 67270.61186343328 77078.53430396495 69633.19534452727 69801.52156726521 70624.04446227168 74477.70269025376 1.086919984374396 1.0641816387616063 1.0181532799072035 1.0105406178460898 0.903231563723251 1.0349209430442265 0.9349535878426006 0.9372136766565373 0.9482575577819699 1.0 16.184520952332115 -5.509900503533069 1.1792291550305953 0.958365850433158 1.0918359478501227 0.6079382962921037 0.03606161078335924 0.40242451681182545 0.9715341083368 0.01196622359175322 0.04844478079057329 3.091003497464352e-06 5.509900503533069 0.1334700974169647 LASVPAGGAVAVSAAPGSAAPAAGS(ph)APAAAEEK ddPTM_A459_Selumetinib_30min_R2 2 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 LASVPAGGAVAVS(0.001)AAPGS(0.2)AAPAAGS(0.799)APAAAEEK;LASVPAGGAVAVSAAPGS(0.019)AAPAAGS(0.981)APAAAEEK 124.13 8.7927e-20 8064000.0 44855.0 47244.0 46761.0 44463.0 47106.0 40966.0 38630.0 38918.0 34216.0 44260.0 True False 42362.138668791806 50867.46288659698 43752.448169527284 38407.06269704682 41188.123147016886 46608.69464767781 40426.371543892805 39031.24493677827 41060.156074918305 42982.098798709565 0.9855763178801225 1.183456934590736 1.0179225629354527 0.8935594996631459 0.9582622602936611 1.084374564070313 0.9405397287185638 0.9080814112769684 0.9552850424361092 1.0 15.391448310257507 -5.5186452799341765 24.743640539584188 0.9624248974542406 1.0885599176408451 0.349274811723965 0.06643613350908394 149.38811549011552 873138.6142340334 0.017828565221185446 0.03186412246058123 3.029386739603319e-06 5.5186452799341765 0.1261350201866045 LASYLDR ddPTM_A459_Selumetinib_30min_R2 2 LASYLDR 7 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 154.01 0.024686000000000003 152299000.0 155427.0 125042.0 151873.0 164510.0 177605.0 129224.0 118977.0 131679.0 129987.0 133204.0 False True 146788.9895635783 134632.31932659954 142101.6565268196 142103.45420442082 155292.67209115467 147023.4330213229 124509.666248453 132062.16408936805 155988.03214023827 129358.05441444441 1.134749515428608 1.040772605432493 1.0985141757895225 1.098528072702315 1.2004870728313486 1.1365618761571752 0.9625196267218283 1.0209040688433675 1.2058625405765246 1.0 16.981010359940022 -9.96346477547482 6.266444632722157 1.0000000016369535 1.0957348869971557 0.14348152136587822 0.0725757814001365 0.0 0.0 0.07313418926303814 0.01773764630443643 1.0877653599457925e-10 9.96346477547482 0.09573488536020225 LATKSS(ph)PVKVGEK ddPTM_A459_Selumetinib_30min_R1 1 LATKSSPVKVGEK 13 2 P49916-4;P49916-3;P49916-2;P49916 P49916-4 LIG3 DNA ligase 3 1 LAT(0.103)KS(0.045)S(0.852)PVKVGEK 94.454 0.017856999999999998 36154000.0 2166.5 1272.9 6525.1 7311.2 3994.4 2675.5 2263.5 2948.4 1972.2 1718.7 True False 2216.9752347248427 1123.8682762448443 5639.027259808693 6034.436168221445 3633.1072252685963 2648.586899159635 2092.762372645694 2870.198854247062 3346.679356211142 1939.3118865556976 1.1431762214701253 0.5795190985194668 2.907746453214316 3.111637797950523 1.8734001737704775 1.3657354020882329 1.0791262546028795 1.4800089011699198 1.7257045550084213 1.0 10.921329125756861 -6.736854975784136 5.4153577259499475 1.3418442271700606 1.974636718360532 0.14464627677204323 0.7181399540672404 0.406733434127346 32.92145517840717 0.27537716173971044 0.2653680765755664 1.8329263903929488e-07 6.736854975784136 0.6327924911904714 LATNT(ph)SAPDLK ddPTM_A459_Selumetinib_30min_R1 1 LATNTSAPDLK 11 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 LATNT(0.675)S(0.325)APDLK 102.33 0.033645999999999995 20878000.0 9957.4 11283.0 10431.0 11021.0 10382.0 8920.9 9765.7 9482.8 5835.5 9337.7 True False 10189.3880462724 9961.981114675602 9014.527493381629 9096.38923979217 9442.949933090977 8831.163845529121 9029.065386589818 9231.285339524497 9902.417291943073 10536.284751900355 0.9670759936926164 0.9454927756084829 0.8555698432273048 0.8633393510128433 0.8962314663513453 0.8381667782788716 0.8569496363470349 0.8761423553838097 0.939839566328828 1.0 13.3630786208225 -8.525832774135242 3.0986728430542385 0.99963379210993 0.8852750418519695 0.4572713867911312 0.03869152889922547 0.22449624147270225 5.457445176289858 0.040633682112750674 0.010815717593209335 2.9796635333251174e-09 8.525832774135242 -0.1143587502579605 LATNTS(ph)APDLK ddPTM_A459_Selumetinib_30min_R1 1 LATNTSAPDLK 11 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 LATNT(0.228)S(0.772)APDLK 126.5 0.0031469 14284000.0 6010.8 8026.2 6881.0 7788.1 6750.3 6187.1 8002.4 6811.2 3730.3 6797.4 True False 6150.839945019192 7086.48877272085 5946.597994627455 6428.054535743168 6139.736556862261 6124.86339143733 7398.772525230798 6630.544850104321 6330.046649667591 7669.912502282941 0.8019439521882943 0.9239334569477246 0.7753149716971942 0.8380870751563156 0.8004962970613778 0.7985571399431572 0.9646488826343927 0.8644876780707402 0.8253088477584926 1.0 12.904994404340425 -7.244006603911951 24.984551079680188 0.9023186645342287 0.8251286570110326 0.35325832579645966 0.05920341263444266 1066.4499106830992 1528431.7881188758 0.022279202497466382 0.017215762594098308 5.701556023892772e-08 7.244006603911951 -0.07719000752319616 LATNTS(ph)APDLK ddPTM_A459_Selumetinib_30min_R2 3 LATNTSAPDLK 11 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 LATNT(0.048)S(0.952)APDLK;LATNT(0.067)S(0.933)APDLK;LATNT(0.411)S(0.589)APDLK 173.19 0.00020433 51687500.0 584800.0 578190.0 577400.0 599860.0 618030.0 492092.0 444600.0 504879.0 380110.0 551090.0 True False 552299.1571398833 622535.3138261253 540250.7126255856 518158.0331837815 540387.5461416979 559873.2062335862 465274.78095818684 506348.1143027823 456142.62116077734 535178.5997962236 1.0319903623765572 1.1632290866323205 1.0094774208671522 0.96819647381468 1.009733099095251 1.0461427389786613 0.8693822606796058 0.9461292258240167 0.8523184995335384 1.0 19.02966090247685 -6.105840899902414 0.6020234540431105 0.9178128690221572 1.1066266842079708 0.43393790563941315 0.06370587534868213 0.9799658331539355 0.6967159048824267 0.04353336395569715 0.10540657571559832 7.837166981438092e-07 6.105840899902414 0.18881381518581364 LATQS(ph)NEITIPVTFESR ddPTM_A459_Selumetinib_30min_R2 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 LAT(0.375)QS(0.587)NEIT(0.038)IPVTFESR 73.296 0.025442 3241300.0 14331.0 17233.0 15594.0 15361.0 22916.0 10612.0 12294.0 10401.0 10455.0 15378.0 True False 13534.540391538418 18554.71568717141 14590.699017463443 13268.805300796974 20037.08720836069 12073.706673855324 12865.69536009884 10431.265188021755 12546.292137107524 14933.997183157608 0.906290541342978 1.242448050552548 0.9770123054475106 0.8884965718194578 1.3417095880370387 0.8084712033742656 0.8615038025190352 0.6984911715254651 0.8401161446084301 1.0 13.866312743581867 LATQSNEITIPVTFESR ddPTM_A459_Selumetinib_30min_R2 2 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 ; 244.67 5.1476e-22 8839700.0 18217.5 16532.2 18423.8 21809.2 19145.4 17590.8 16351.7 15833.699999999999 13730.5 19636.5 False True 17205.044280430615 17800.166580598587 17238.432766316728 18838.74933703154 16740.18368995238 20013.773026616498 17112.086450278868 15879.773445589859 16476.983662224276 19069.54322324582 0.9022263448585189 0.9334343446097934 0.903977225070763 0.9878972514699281 0.8778492223949055 1.04951507187753 0.8973516696204444 0.8327296180976363 0.8640471074387768 1.0 14.218982666438166 -10.648429044875094 4.939743405090516 1.0000039036324981 0.9185246461606068 0.150760035368123 0.05924692843543394 2.62402128192695e-06 4.6452658444498213e-07 0.059099385223117674 0.014333019570199623 2.2468338341961617e-11 10.648429044875094 -0.08147925747189133 LAVEEFVHAT(ph)SEGEAPGGCEGR ddPTM_A459_Selumetinib_30min_R1 2 LAVEEFVHATSEGEAPGGCEGR 22 0 Q5C9Z4 Q5C9Z4 NOM1 Nucleolar MIF4G domain-containing protein 1 1 LAVEEFVHAT(0.5)S(0.5)EGEAPGGCEGR;LAVEEFVHAT(0.5)S(0.5)EGEAPGGCEGR 160.12 4.9597e-09 10063800.0 2482.6 3055.8 2673.8 3147.5 3432.6 2292.7 3303.6 2760.4 1001.0 2192.5 True False 2540.439749701312 2698.025515397123 2310.7126461320872 2597.8482108924645 3122.121936074751 2269.637519605044 3054.406792256381 2687.185224957126 1698.623889852628 2473.928731758519 1.0268847752519998 1.0905833627144592 0.9340255507237614 1.0500901572236727 1.2620096512867138 0.9174223535500715 1.2346381498569872 1.0862015507807374 0.6866098720011273 1.0 11.272588224822965 -8.234976766528652 24.35227314458982 0.8433049337060797 1.0764778894253229 0.3531984039959688 0.12553248191925617 482.3588507888447 443893.3244088889 0.08083590466961019 0.030529298772704785 5.821343594057673e-09 8.234976766528652 0.23317295571924312 LAVEEFVHATS(ph)EGEAPGGCEGR ddPTM_A459_Selumetinib_30min_R1 2 LAVEEFVHATSEGEAPGGCEGR 22 0 Q5C9Z4 Q5C9Z4 NOM1 Nucleolar MIF4G domain-containing protein 1 1 LAVEEFVHAT(0.012)S(0.988)EGEAPGGCEGR;LAVEEFVHAT(0.164)S(0.836)EGEAPGGCEGR 158.12 3.3544000000000003e-09 12842200.0 2774.6 3130.4 3143.8 3270.3 3710.6000000000004 2734.2 3441.6 3007.2 982.8399999999999 2345.0 True False 2839.2427815682195 2763.8913127165233 2716.889227657287 2699.203496133956 3374.976885159639 2706.6964304549683 3181.9973411519427 2927.439287237744 1667.8076962065509 2646.0035922343113 1.073030584652659 1.044553121858261 1.0267896973500021 1.020105756490951 1.275499736683946 1.0229375494420276 1.202567279383409 1.106362552125557 0.6303119546403327 1.0 11.369599304893608 -8.235710216141582 24.614277619991274 0.8151559839322445 1.09693309349954 0.4913606690082999 0.11449063382440744 419.45326803275725 401279.06257151143 0.0733926885181862 0.027715190795922058 5.811520630503681e-09 8.235710216141582 0.2817771095672955 LAVLSSS(ph)LTHWK ddPTM_A459_Selumetinib_30min_R1 1 LAVLSSSLTHWK 12 0 F5GX19;F5H3Y3;Q6IAA8 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 LAVLS(0.004)S(0.036)S(0.798)LT(0.161)HWK 139.74 0.00074909 24668000.0 9239.2 6092.8 7799.2 4877.4 9067.6 7367.6 7129.9 9884.1 2820.8 6082.4 True False 9454.45538364633 5379.452143534126 6740.111477939032 4025.6536501372225 8247.437181014808 7293.48863324557 6592.085902684579 9621.941559918385 4786.691576919378 6863.135287593166 1.3775708896104122 0.7838184616961917 0.9820746926151186 0.5865618964869596 1.2017010936567305 1.0627050651952579 0.9605064779360278 1.401974630649122 0.6974496897318229 1.0 12.744652078337616 LAVLSSS(ph)LTHWK ddPTM_A459_Selumetinib_30min_R2 2 LAVLSSSLTHWK 12 0 F5GX19;F5H3Y3;Q6IAA8 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 LAVLS(0.03)S(0.259)S(0.536)LT(0.175)HWK;LAVLS(0.043)S(0.225)S(0.683)LT(0.049)HWK 70.628 0.041464 8612800.0 46444.0 20913.0 35686.0 53490.0 36753.0 36992.0 62377.0 53604.0 47692.0 36844.0 True False 43862.828410062786 22516.959854106397 33390.00161197903 46204.56972460325 32135.75956401121 42087.31222005803 65277.65409768066 53759.978765380096 57231.732625818404 35780.21798779157 1.2258960642729748 0.6293130987013361 0.933197266248403 1.2913439974113219 0.8981432023409172 1.1762732198674273 1.824406271643001 1.5025056243012083 1.5995356049911775 1.0 15.126874556457098 -7.041424046427182 6.351017835063095 1.5230641171179327 0.9919566243049758 0.4404276918905925 0.256737044083429 0.17764287526623965 19.684858877889315 0.09467617234048144 0.0746726977819435 9.090252641971134e-08 7.041424046427182 -0.5311074928129569 LAVLSSSLT(ph)HWK ddPTM_A459_Selumetinib_30min_R1 1 LAVLSSSLTHWK 12 0 F5GX19;F5H3Y3;Q6IAA8 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 LAVLS(0.001)S(0.014)S(0.104)LT(0.881)HWK 149.57 0.00077624 23774000.0 8294.6 6029.7 6947.2 4453.7 7291.8 6529.2 6386.6 8492.4 2666.9 4978.0 True False 8487.848041517962 5323.739920868521 6003.80839823803 3675.9449013031826 6632.25797747185 6463.522176039272 5904.853620118844 8267.153964797093 4525.534517330646 5616.97478982618 1.5111066649064704 0.9477948753680033 1.0688686744887137 0.654435000840895 1.1807526694769246 1.1507123350004014 1.0512515795538353 1.47181610638009 0.8056889494194598 1.0 12.455577612471904 -6.39922427124867 24.028730980551988 1.1327233640688152 1.0249105764822297 0.008145842939494607 0.2510673131170813 44.34866926274394 8445.515654089702 0.07608302240991127 0.08627002718731758 3.988188976478854e-07 6.39922427124867 -0.10781278758658552 LAVPTEVSTEVPEMDT(ph)ST ddPTM_A459_Selumetinib_30min_R1 1 LAVPTEVSTEVPEMDTST 18 0 O00488 O00488 ZNF593 Zinc finger protein 593 1 LAVPTEVSTEVPEMDT(0.333)S(0.333)T(0.333) 99.834 0.0068590000000000005 2753300.0 1850.6 1778.9 2124.5 2295.0 1860.5 2006.7 1846.7 1863.9 828.88 1550.7 True False 1893.7153793592393 1570.625561011826 1836.0045690431677 1894.2213324855315 1692.2181034979546 1986.5144199378196 1707.4019322133001 1814.4633171995322 1406.5488210000472 1749.7474500971198 1.0822792622181725 0.8976298613406457 1.0492968964985547 1.082568420019925 0.9671213427995154 1.1353149392088315 0.9757990686704705 1.036985833069121 0.8038581916047236 1.0 10.772930990270767 -8.230993471895166 24.888551600051436 0.9019290571893765 1.0262905919633942 0.29630250404443825 0.07789204053888683 662.070694846757 541223.221996924 0.04937584480155242 0.018657484861559815 5.874981834522644e-09 8.230993471895166 0.12436153477401768 LAYIAHPK ddPTM_A459_Selumetinib_30min_R2 2 LAYIAHPK 8 0 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 0 ; 106.42 0.019301 10952500.0 216060.0 191984.0 237770.0 258020.0 253810.0 171868.0 186037.0 191686.0 164291.0 216460.0 False True 204052.2501567086 206708.55547414336 222472.13706440185 222877.2308906738 221924.11870981078 195541.25693763338 194688.08912532195 192243.7745246746 197153.79067408238 210210.23736937813 0.9707055789017125 0.9833420011363116 1.058331601012739 1.0602586899658812 1.0557245997484375 0.9302175735334496 0.9261589328935446 0.9145309806527969 0.9378886258885996 1.0 17.681473405594126 -6.770532004317205 24.99990802126261 0.9354423715041514 1.0270566510453922 0.5777423711297484 0.035655584167227354 141.07798966488545 387887.57726729 0.013311957218082114 0.011908430165287403 1.6961646027667034e-07 6.770532004317205 0.0916142795412408 LCAGIMITAS(ph)HNPK ddPTM_A459_Selumetinib_30min_R1 2 LCAGIMITASHNPK 14 0 Q96G03-2;Q96G03 Q96G03-2 PGM2 Phosphoglucomutase-2 1 LCAGIMIT(0.001)AS(0.999)HNPK;LCAGIMIT(0.003)AS(0.997)HNPK 127.05 0.00082547 54323000.0 7246.8 9384.2 7682.8 9398.5 6255.9 6910.9 6278.0 5793.3 4531.11 5824.5 True False 7415.636340181853 8285.493501403784 6639.517958599594 7757.228406695099 5690.05494956885 6841.382620595142 5804.445405553204 5639.642864709503 7688.962730819329 6572.131310434428 1.1283457359423434 1.2607011500590513 1.0102533934552065 1.1803215791472574 0.86578534128417 1.0409686443320494 0.883190723279922 0.8581147573475237 1.1699344349087688 1.0 12.682145590120502 -6.2496807619167605 24.999999987664726 0.9618127902696444 1.1435585882824046 0.39938197095502737 0.10500958505466318 747.974663235127 1590268.6838748448 0.030151102042325954 0.03860833243571429 5.62754838994586e-07 6.2496807619167605 0.18174579801276025 LCAGIMITAS(ph)HNPK ddPTM_A459_Selumetinib_30min_R2 5 LCAGIMITASHNPK 14 0 Q96G03-2;Q96G03 Q96G03-2 PGM2 Phosphoglucomutase-2 1 LCAGIMIT(0.001)AS(0.999)HNPK;LCAGIMIT(0.004)AS(0.996)HNPK;LCAGIMIT(0.001)AS(0.999)HNPK;LCAGIMITAS(1)HNPK;LCAGIMIT(0.002)AS(0.998)HNPK 114.01 0.0020586 25410700.0 234089.0 229014.0 232973.0 217870.0 237244.0 175374.5 172435.3 192218.0 148967.8 216635.0 True False 221079.27051251408 246578.637403927 217983.77082182278 188195.73015328695 207439.28773172977 199530.74548379553 180453.88312406495 192777.32255659718 178765.52250810157 210380.18466467306 1.0508559580594266 1.1720620827334618 1.0361421213184556 0.8945506462657302 0.986021036450601 0.9484293675368213 0.8577513296306497 0.9163283265668141 0.8497260461722552 1.0 17.682639300586658 -5.587700089627829 3.96534042376288 0.9198299498941015 1.1113642078022963 0.6765729228894064 0.053648129556455294 0.1150353493232369 3.619279399359669 0.014619296123330558 0.02733529369039814 2.5840440357284986e-06 5.587700089627829 0.19153425790819478 LCDDGPQLPT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 2 LCDDGPQLPTSPR 13 0 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 LCDDGPQLPT(0.5)S(0.5)PR;LCDDGPQLPT(0.655)S(0.345)PR 209.11 2.0684e-05 300270000.0 10587.05 16352.7 12376.01 13775.9 12105.3 10527.23 13607.02 11696.62 6139.66 10115.29 True False 10833.70766618677 14438.118281836025 10695.415818556807 11370.1976706699 11010.377752364304 10421.335624160074 12580.631526325353 11386.387641623684 10418.554596975617 11413.686002768356 0.9491857112206422 1.2649829580324972 0.9370693933548431 0.9961898082628252 0.9646645044987018 0.9130560996362095 1.1022408995020503 0.9976082782426245 0.91281244240017 1.0 13.478477158831167 -5.313415791407311 24.99997037261196 0.9801672651346224 1.1070859841745058 0.2573929164281512 0.08766902407108643 379.1812936584219 182380.56482976698 0.02160996763802614 0.04498478766915593 4.8594174466854635e-06 5.313415791407311 0.1269187190398834 LCDDGPQLPTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 LCDDGPQLPTSPR 13 0 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 LCDDGPQLPT(0.069)S(0.931)PR;LCDDGPQLPT(0.002)S(0.998)PR;LCDDGPQLPT(0.027)S(0.973)PR 242.4 5.4603e-18 544940000.0 20458.9 25311.0 23515.6 25304.1 24096.6 20791.0 25528.8 22932.1 11825.0 18860.9 True False 20935.552563910478 22347.57635323535 20322.3106819447 20885.213951785237 21917.06678460027 20581.861416717606 23603.142062645205 22323.86621404118 20066.16133617116 21281.880235723715 0.9837266412564483 1.0500752802716538 0.9549114296692505 0.9813613139654533 1.0298463548258454 0.9671072851058029 1.1090722154814605 1.0489611804397052 0.942875399819615 1.0 14.377337996879273 LCDDGPQLPTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 LCDDGPQLPTSPR 13 0 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 LCDDGPQLPT(0.109)S(0.891)PR;LCDDGPQLPT(0.007)S(0.993)PR;LCDDGPQLPT(0.025)S(0.975)PR;LCDDGPQLPT(0.007)S(0.993)PR;LCDDGPQLPT(0.002)S(0.998)PR;LCDDGPQLPT(0.079)S(0.921)PR;LCDDGPQLPT(0.237)S(0.763)PR 258.39 1.3727e-29 1159790300.0 950159.0 919186.0 1048296.0 1128490.0 1213465.0 813848.0 842405.0 890025.0 862160.0 950333.0 True False 897352.9665678415 989684.6105511724 980849.7766583837 974787.7152461666 1061018.6781852597 925948.1746234279 881578.501693839 892614.8253984285 1034616.09076314 922894.4170283334 0.9723246235005583 1.0723703516789056 1.0627973889111424 1.0562288570180396 1.1496642070949767 1.0033088916118134 0.9552322404684933 0.9671906221652056 1.121055747736067 1.0 19.815806081416696 LCDFGISGQLVDS(ph)IAK ddPTM_A459_Selumetinib_30min_R1 2 LCDFGISGQLVDSIAK 16 0 P45985;P45985-2 P45985 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 1 LCDFGISGQLVDS(1)IAK;LCDFGISGQLVDS(1)IAK 182.76 1.2394e-13 11340000.0 3164.6000000000004 4498.8 3708.5 3512.7 2873.4 3811.6000000000004 2688.2 2632.7 1945.12 2153.0 True False 3238.3290227603215 3972.0784045646196 3204.9060693323536 2899.2728865454987 2613.5014773399726 3773.2587646559004 2485.4269097177626 2562.8722437851843 3300.726574056088 2429.3585219959355 1.3329975767017477 1.6350317866220923 1.319239643022816 1.1934314594963475 1.0757990035957095 1.5531914003190566 1.023079503175086 1.0549584265065806 1.3586823616895565 1.0 11.246359701658102 -1.5228787452971777 0.16966000663916975 1.0180555234900945 2.9436741496124044 0.29440959753410967 0.1779982972826979 73.91216366895873 0.7988682457644368 0.4655473101057061 36.09736156194516 0.029999999998836725 1.5228787452971777 1.9256186261223098 LCDFGSASHVADNDITPY(ph)LVSR ddPTM_A459_Selumetinib_30min_R1 5 LCDFGSASHVADNDITPYLVSR 22 0 Q13523;H0YDJ3 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 LCDFGSASHVADNDIT(0.125)PY(0.871)LVS(0.004)R;LCDFGSASHVADNDIT(0.214)PY(0.753)LVS(0.033)R;LCDFGSASHVADNDIT(0.051)PY(0.949)LVSR;LCDFGSASHVADNDIT(0.184)PY(0.509)LVS(0.306)R;LCDFGSASHVADNDITPY(0.999)LVS(0.001)R 293.08 1.4905999999999992e-91 1010384500.0 21798.9 24423.0 22357.699999999997 26728.1 30984.1 21706.300000000003 27199.6 21959.0 7873.02 15230.529999999999 True False 22306.771956724384 21563.543806055324 19321.647142055266 22060.539083575826 28181.593625687146 21487.95432974352 25147.9122734764 21376.575987115473 13359.939917370173 17185.516883425335 1.2979983149787175 1.254750959911622 1.1242982840213631 1.2836703855472764 1.6398455639624687 1.2503525192464646 1.463320099364043 1.243871576986563 0.777395292093614 1.0 14.06890562340049 -8.15149867038066 5.022153061200684 0.8938162129458542 1.3280087663286504 0.6039132808923566 0.14071845280772716 0.15050877361734835 5.528705636616939 0.10475061481097858 0.03746535669877516 7.055070040005497e-09 8.15149867038066 0.43419255338279616 LCDFGSASHVADNDITPY(ph)LVSR ddPTM_A459_Selumetinib_30min_R2 11 LCDFGSASHVADNDITPYLVSR 22 0 Q13523;H0YDJ3 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 LCDFGSASHVADNDIT(0.081)PY(0.898)LVS(0.021)R;LCDFGSASHVADNDIT(0.063)PY(0.931)LVS(0.006)R;LCDFGSASHVADNDIT(0.009)PY(0.99)LVS(0.001)R;LCDFGSASHVADNDIT(0.081)PY(0.916)LVS(0.003)R;LCDFGSASHVADNDIT(0.173)PY(0.827)LVSR;LCDFGSASHVADNDIT(0.334)PY(0.547)LVS(0.119)R;LCDFGSASHVADNDIT(0.02)PY(0.98)LVS(0.001)R;LCDFGSASHVADNDIT(0.088)PY(0.91)LVS(0.003)R;LCDFGSASHVADNDIT(0.06)PY(0.939)LVS(0.001)R;LCDFGSASHVADNDIT(0.075)PY(0.799)LVS(0.126)R;LCDFGSASHVADNDIT(0.196)PY(0.765)LVS(0.039)R 186.6 9.0295e-21 298499200.0 342662.8 317256.19999999995 464477.60000000003 547951.5 583168.3 397787.2 345304.39999999997 384562.5 373573.1 484048.3 True False 323618.9733638721 341588.73040053336 434593.6169009746 473319.5604309384 509905.48456325114 452578.7760473261 361361.73880768806 385681.51320725045 448298.15850453114 470072.5678704787 0.6884447114834412 0.7266723347588598 0.9245245236703967 1.006907428304462 1.084737803086922 0.962784912332998 0.7687360707831301 0.8204722835762649 0.9536786214422383 1.0 18.842523965749194 -5.241965798963863 4.227031141153716 0.9370688177788322 0.6992202910925455 0.5420321219011939 0.08585118582789306 0.17818092370139732 7.8024171777770475 0.0258615106400352 0.06935622779756716 5.728411409053983e-06 5.241965798963863 -0.23784852668628675 LCDFGSASHVADNDITPYLVS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 LCDFGSASHVADNDITPYLVSR 22 0 Q13523;H0YDJ3 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 LCDFGSASHVADNDIT(0.048)PY(0.306)LVS(0.646)R 99.881 0.00034681 0.0 6081.0 5344.1 5269.5 8166.5 7244.2 5732.6 4338.9 4536.8 5204.6 4893.6 True False 5743.042364171737 5753.97528601014 4930.466106997799 7054.208612001723 6334.1188320303045 6522.21361463843 4540.667447367246 4550.001336892327 6245.665428674296 4752.309052900251 1.208474091277136 1.2107746406977866 1.0374885244445164 1.484374970877928 1.3328507808566663 1.3724304421359206 0.9554655214597535 0.9574295960645786 1.3142380596781003 1.0 12.214412945419523 -7.261711478561886 24.99975533620351 1.0532357604603821 1.2729395121796403 0.3495835428248204 0.1453768551764539 30.266756083984067 2780614.214740874 0.06032928926906382 0.04360995305942167 5.473794910433947e-08 7.261711478561886 0.21970375171925816 LCDFGSASHVADNDITPYLVSR ddPTM_A459_Selumetinib_30min_R1 1 LCDFGSASHVADNDITPYLVSR 22 0 Q13523;H0YDJ3 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 89.816 0.00060922 9253700.0 397.09 481.41 710.69 835.65 679.16 631.39 559.42 692.04 251.26 291.68 False True 406.3414243973632 425.04629339856285 614.1822015407332 689.7194145932607 617.7300979154368 625.0387898562515 517.2224990083743 673.6848511372737 426.36986869567556 329.1199692037967 1.2346301118719103 1.2914630930077868 1.8661347198912173 2.095647420792552 1.8769146685624771 1.8991214400278968 1.5715318042221293 2.046927911323778 1.2954846517734695 1.0 8.362469753755278 -5.250769293629127 21.28228943687432 1.7659082242073743 1.2630456842911886 0.21031556121434225 0.3278909129185063 119.02636546084454 237394.8859568934 0.07857392090689973 0.201618047806906 5.6134609570435225e-06 5.250769293629127 -0.5028625399161857 LCDPDGLS(ph)DEEDQKPVR ddPTM_A459_Selumetinib_30min_R2 1 LCDPDGLSDEEDQKPVR 17 1 Q96RY5 Q96RY5 CRAMP1L Protein cramped-like 1 LCDPDGLS(1)DEEDQKPVR 114.54 0.0080807 3849600.0 15679.0 16483.0 18075.0 15320.0 17513.0 12514.0 14496.0 15595.0 10587.0 13269.0 True False 14807.623948009965 17747.193098801512 16912.074178572006 13233.389571525917 15312.860371793533 14237.689909218376 15170.092723279065 15640.378868108777 12704.695825495666 12885.889492997681 1.1491347924453779 1.3772578996929556 1.3124491085976016 1.0269674886407392 1.1883432944318428 1.1049054795134845 1.1772639158144762 1.2137601270450062 0.9859385983714607 1.0 13.653504507188943 -4.05376496622603 0.10899055125894254 0.8937924447442441 1.6938953281094264 0.36533386450186545 0.09782133744525442 67.07360353777776 0.9545471987989245 1.2829357435203028 8.15674035767439 8.835579395900733e-05 4.05376496622603 0.8001028833651823 LCGPES(ph)PPPPYSR ddPTM_A459_Selumetinib_30min_R2 2 LCGPESPPPPYSR 13 0 O43541-4;O43541 O43541-4 SMAD6 Mothers against decapentaplegic homolog 6 1 LCGPES(1)PPPPYSR;LCGPES(0.992)PPPPYS(0.008)R 122.52 0.0026312 5679300.0 31105.8 30964.5 26237.2 31235.6 28373.7 18828.1 26361.6 26890.9 17046.2 24759.0 True False 29377.064162383354 33339.377583439855 24549.12711690343 26981.257395584522 24809.14214190364 21421.499870525386 27587.46663451942 26969.148066971855 20455.916310622863 24044.143338392438 1.221797081681658 1.3865903689820909 1.0210023610075831 1.1221550718549516 1.0318164300031307 0.8909238132980454 1.1473674169322219 1.1216514428238715 0.8507650292518394 1.0 14.553397905327655 -5.2709165917309795 24.853949124290313 1.0311056636701779 1.3041937258892136 0.5651162400841651 0.09840101272292158 389.8998273670104 1022512.4423572093 0.025422691712138495 0.05408894816739738 5.358995696278994e-06 5.2709165917309795 0.2730880622190357 LCLS(ph)TVDLEVK ddPTM_A459_Selumetinib_30min_R1 1 LCLSTVDLEVK 11 0 Q8N370-4;Q8N370-2;Q8N370;Q8N370-3 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 LCLS(0.5)T(0.5)VDLEVK 187.58 1.9338e-05 11974000.0 3100.8 1971.1 2957.3 1553.9 2961.9 2369.8 2766.0 3912.5 1196.1 2791.9 True False 3173.0426068935103 1740.3226956604708 2555.714903286118 1282.540535315584 2693.9966679659187 2345.961963606242 2557.3583930806253 3808.7277904089106 2029.694340312417 3150.2675604089422 1.0072295594097447 0.5524364715975287 0.811269155485433 0.40712114470337085 0.8551643999458274 0.7446865761782178 0.8117908539643692 1.2090172397656573 0.6442926835233445 1.0 11.621258650316648 -7.531264350814777 24.993387371110686 0.9580738200535805 0.7215079193063378 0.19665311091825155 0.19967685010411826 286.8339095814654 854898.0001783532 0.08826871562702693 0.05106716446341715 2.9426299384209117e-08 7.531264350814777 -0.2365659007472427 LCPSCPAS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 LCPSCPASSPK 11 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 LCPSCPAS(0.5)S(0.5)PK 177.04 6.6993e-05 23042000.0 4312.0 4934.4 5993.3 6379.1 3890.9 4355.8 4911.6 4876.1 2962.0 4413.3 True False 4412.461210308571 4356.678154059674 5179.44277884039 5265.1099355374545 3538.9687819941882 4311.984606749965 4541.114057648152 4746.769988194989 5026.297664079406 4979.790044182382 0.886073744306431 0.8748718551195435 1.0400926008700409 1.0572955664442913 0.7106662631547234 0.8658968688423766 0.9119087385929631 0.953206851308999 1.0093392732393118 1.0 12.281869201934919 -8.008723896548329 2.6743970055798796 1.0041950222978895 0.9072564629853719 0.15812842612792088 0.09062794844429313 0.6112040930307955 8.325982791034122 0.07629546891488904 0.026774238830414413 9.801128958113537e-09 8.008723896548329 -0.0969385593125176 LCPSCPASS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 LCPSCPASSPK 11 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 LCPSCPAS(0.139)S(0.861)PK;LCPSCPAS(0.088)S(0.912)PK 121.68 0.0043711 28033000.0 10644.6 12652.4 14326.3 13483.7 9795.5 10666.6 10516.3 10485.400000000001 7017.3 10441.7 True False 10892.598469213963 11171.051126058823 12380.86714873294 11129.024915396583 8909.498754535989 10559.303688497903 9723.04702427829 10207.29313062073 11907.845576686164 11781.993905771003 0.9245123156852593 0.9481460621522703 1.050829532569067 0.944579075868085 0.7561961774714532 0.8962238287464902 0.8252463124697248 0.8663468350311265 1.010681695468669 1.0 13.524296091429708 -6.012524147273364 24.974666517825387 0.8796671244444636 0.9761682070570021 0.18003982447322242 0.07702659157435542 837.4136463351599 1669908.4425464843 0.022076781193773758 0.03004667984336841 9.715739294458497e-07 6.012524147273364 0.09650108261253854 LCPSCPASS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 LCPSCPASSPK 11 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 LCPSCPAS(0.319)S(0.681)PK;LCPSCPAS(0.077)S(0.923)PK 174.23 0.00014431 102979000.0 232100.0 190713.0 199421.0 175791.0 152013.0 125589.0 175770.0 154892.0 104065.0 147186.0 True False 219200.81116991577 205340.07386105304 186590.46997316822 151847.9625436108 132915.76792653737 142887.74476656763 183943.65328164728 155342.71007624906 124880.9078190429 142936.3577448455 1.5335553153047967 1.4365839251872075 1.3054094347797032 1.0623466621044964 0.9298947449311966 0.9996598977401912 1.286891985942468 1.0867963373849923 0.8736818944412084 1.0 17.125013406031826 -5.542603442746124 2.107691831086993 1.039628176918447 1.496806835466295 0.7561203864308836 0.1051885748421628 0.17210997427269573 1.5089106542376038 0.03318760933258934 0.08159277836742704 2.866794464736145e-06 5.542603442746124 0.4571786585478479 LCS(ph)SSSSDTSSR ddPTM_A459_Selumetinib_30min_R1 1 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.378)S(0.378)S(0.202)S(0.01)S(0.032)DTSSR 179.59 0.00010389 7089900.0 1386.1 1672.9 1914.0 1886.7 1613.2 1520.9 2053.3 1826.9 1097.4 1172.8 True False 1418.3934331189023 1477.0360902898894 1654.089312849433 1557.2232627452947 1467.2863448335931 1505.601126866711 1898.417927878687 1778.4446773924685 1862.2076490751995 1323.3403040394023 1.0718281826597111 1.1161422997405441 1.2499349621563274 1.1767368212031186 1.1087747727132664 1.1377278559951438 1.4345651848461813 1.3439057753805974 1.4072023978948898 1.0 10.369968390737318 -7.238565639781842 24.17721967638359 1.325077153801988 1.1470465000916188 0.26754941313355485 0.1201639905974826 578.1103334412425 611054.9036326066 0.04368966323465739 0.033812664002965946 5.773436057236648e-08 7.238565639781842 -0.1780306537103693 LCS(ph)SSSSDTSSR ddPTM_A459_Selumetinib_30min_R2 1 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.726)S(0.009)S(0.009)S(0.038)S(0.216)DT(0.001)SSR 84.352 0.032747000000000005 2421100.0 15180.0 11345.0 15811.0 16825.0 13380.0 10011.0 11193.0 11903.0 9286.2 13121.0 True False 14336.356370354692 12215.12502007542 14793.737473715193 14533.405975256115 11699.08478128233 11389.92437919012 11713.496678508736 11937.635759352279 11143.699478106922 12742.162637547855 1.1251117081263082 0.958638291437327 1.1610068003779734 1.1405760849755542 0.9181396529038294 0.8938768640126254 0.9192706930291482 0.936861041482484 0.8745532289212291 1.0 13.637322536396448 -6.271702890970013 24.598657284998815 0.9189056401441572 1.091117409885165 0.6671179560437001 0.05960705322491959 339.3899656829035 813417.3997201847 0.0184094242412224 0.021113748531806694 5.349301900591298e-07 6.271702890970013 0.17221176974100783 LCSS(ph)SSSDTSSR ddPTM_A459_Selumetinib_30min_R1 2 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.051)S(0.478)S(0.235)S(0.235)S(0.001)DTSSR;LCS(0.038)S(0.554)S(0.348)S(0.011)S(0.048)DTSSR 218.94 3.9727e-08 63844600.0 3675.3 4256.799999999999 3992.0 4641.3 5258.5 4104.8 4865.5 4643.7 2471.0 2663.2 True False 3760.9273391111055 3758.4118770673695 3449.9083264863825 3830.7840829913243 4782.8696034635805 4063.5094388601983 4498.491417763475 4520.5339911365745 4193.106525300545 3005.0476617647837 1.251536668440864 1.2506995895233672 1.1480378066484125 1.2747831362986128 1.5916118949856288 1.3522279498468281 1.4969783923898337 1.5043135750072552 1.3953544160554334 1.0 11.55317215774377 -6.01794500955861 23.03202692890806 1.4200624753125382 1.2186951779646882 0.19959674297755114 0.15205371211368873 330.12062666417256 423704.3305589171 0.04135144693673654 0.05463709713029615 9.595221186787714e-07 6.01794500955861 -0.20136729734784997 LCSSS(ph)SSDTSSR ddPTM_A459_Selumetinib_30min_R2 2 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.007)S(0.097)S(0.439)S(0.439)S(0.018)DTSSR;LCS(0.166)S(0.166)S(0.634)S(0.007)S(0.027)DTSSR 230.81 5.1644e-10 214700000.0 165411.0 156651.0 178907.0 197984.0 202282.0 147270.0 141652.0 162110.0 151590.0 189629.0 True False 156218.11881269718 168665.62798764496 167396.31839921372 171018.23765855018 176869.52673597552 167555.10571604525 148239.09867811293 162581.71326124485 181912.2357784913 184153.91805468794 0.8483019012731801 0.9158948653894866 0.9090022094968528 0.9286701008868197 0.960444005777009 0.9098644627603668 0.8049739057633875 0.88285774735981 0.9878271268953891 1.0 17.490552566748782 -8.274846336794612 13.732291690127362 0.99393697083474 0.8969624725293641 0.4817332794334541 0.040997449792766864 2.248628754323578 2289.1470758367605 0.040139787622382676 0.01119579563287506 5.3107231638331455e-09 8.274846336794612 -0.09697449830537586 LCSSSS(ph)SDTSSR ddPTM_A459_Selumetinib_30min_R2 1 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.234)S(0.234)S(0.115)S(0.396)S(0.02)DTSSR 151.16 0.00052989 23404000.0 29097.0 33581.0 33672.0 39836.0 40578.0 32422.0 32467.0 37916.0 31633.0 44718.0 True False 27479.9052245198 36156.55472006636 31505.5801793016 34410.26807906703 35480.228868077334 36887.83620238758 33976.779832140004 38026.329282668295 37960.48389986821 43426.87514868263 0.6327856915892649 0.8325847668356395 0.7254857751434904 0.7923726485328493 0.8170108658889688 0.8494241429090389 0.7823906213793212 0.8756404680851608 0.8741242322847573 1.0 15.406300524611739 -4.736956750420626 0.04838645913278274 1.4589167674908003 6.220309713155705e-10 0.7358980362296661 0.04754284407608571 131.48605882043708 0.98900132215646 10.272881490202039 20.853996281386998 1.832496904022285e-05 4.736956750420626 -1.4589167668687695 LCSSSSS(ph)DTSSR ddPTM_A459_Selumetinib_30min_R1 1 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.035)S(0.035)S(0.294)S(0.01)S(0.626)DTSSR 216.91 5.077e-08 49932000.0 2193.3 2257.2 2983.2 3108.7 2555.1 2080.8 2956.0 3165.5 1643.0 1859.2 True False 2244.399622581119 1992.925974656188 2578.097825544634 2565.8239025262624 2323.9916561395435 2059.8690412152364 2733.0265401107463 3081.5406570068762 2788.05100002784 2097.846430141592 1.069858875432381 0.9499865891144746 1.2289259063498885 1.2230751811290042 1.1077987514952121 0.9818969642483352 1.302777219935152 1.4689066905621355 1.3290062418151662 1.0 11.034693356008036 -7.333086975387438 8.838145781944318 1.315053189077694 1.0998592833102154 0.27384614078940317 0.13871692647643516 0.46797993983112496 54.53570038989832 0.058217560685560846 0.03919012752039986 4.644222568851265e-08 7.333086975387438 -0.21519390576747854 LCSSSSS(ph)DTSSR ddPTM_A459_Selumetinib_30min_R2 1 LCSSSSSDTSSR 12 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LCS(0.152)S(0.016)S(0.008)S(0.026)S(0.785)DT(0.013)SSR 147.58 0.00062591 28665000.0 23888.0 24784.0 29663.0 29547.0 33873.0 24606.0 18886.0 27970.0 29338.0 31197.0 True False 22560.400591240646 26684.853106879615 27754.514874632456 25522.64762858202 29617.570911537852 27995.25314897137 19764.236421899048 28051.388069317225 35206.41977221046 30296.26155045961 0.7446595532476974 0.8807968951032109 0.9161036198610255 0.8424355455894468 0.9775982050527464 0.9240497578337901 0.652365520048767 0.9259026240777773 1.1620714230226983 1.0 14.886852160859407 -8.012472834036293 24.25648101412715 1.0686862432798268 0.8547599878199557 0.4807885523020271 0.0953977838000976 353.1559473076604 686793.2318954034 0.05921335688067813 0.02487060881266438 9.716887306943227e-09 8.012472834036293 -0.2139262554598711 LCYVALDFEQEMATAASS(ph)SSLEK ddPTM_A459_Selumetinib_30min_R1 1 LCYVALDFEQEMATAASSSSLEK 23 0 P60709;A0A2R8Y793;Q6S8J3;A0A2R8YEA7;P63261;I3L4N8 P60709;P63261 ACTB;POTEE;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 LCYVALDFEQEMATAAS(0.125)S(0.756)S(0.116)S(0.003)LEK 210.58 3.3516e-24 1811300.0 485.72 637.01 627.26 748.92 565.06 533.71 591.1 606.24 449.28 533.35 True False 497.0363309534044 562.4285730620852 542.0815372925473 618.1351809695266 513.9504227694456 528.3413619699078 546.5128511026601 590.1605458549515 762.3953458871018 601.8106677689425 0.8259014962231197 0.9345606570038776 0.9007509609329035 1.0271256627289493 0.8540068335358427 0.8779195688381478 0.9081142631264999 0.9806415496800999 1.2668358783228046 1.0 9.23316587006004 -8.050154157837161 5.876545643910769 1.1340149966694282 0.9090356110740262 0.572655327776781 0.07828936556626288 0.14312097405623123 11.504856943566821 0.05026058770317616 0.019058892214550694 8.909346344713045e-09 8.050154157837161 -0.22497938559540198 LDAQSLNLSQEDFDRYMS(ph)GQTSPR ddPTM_A459_Selumetinib_30min_R1 2 LDAQSLNLSQEDFDRYMSGQTSPR 24 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;A0A0A0MSJ3;Q3HKR1 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 LDAQSLNLS(0.001)QEDFDRY(0.074)MS(0.308)GQT(0.308)S(0.308)PR;LDAQSLNLSQEDFDRY(0.018)MS(0.327)GQT(0.327)S(0.327)PR 72.167 0.00054932 33168600.0 1559.79 1364.09 2115.4 2066.88 1618.5 1439.29 1171.37 1107.85 903.03 904.0 True False 1596.1300721769949 1204.3817086517631 1828.140299060444 1705.938208142787 1472.1069607693828 1424.8120493707606 1083.012617824603 1078.4662191960408 1532.3759552983213 1020.0372057056788 1.5647763270289394 1.1807233127526477 1.7922290371709588 1.6724274355880875 1.4431894763593005 1.3968236074144489 1.061738348137367 1.057281257157615 1.5022745706988188 1.0 9.994406059906057 -6.989355887632371 2.660835325513156 1.1618753147176186 1.5356173254099794 0.4461416318615845 0.19643833824387777 0.27824768124306615 3.9810515169858274 0.0813940560494345 0.06568528864678258 1.0248117882043313e-07 6.989355887632371 0.3737420106923608 LDAQSLNLSQEDFDRYMSGQT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 LDAQSLNLSQEDFDRYMSGQTSPR 24 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;A0A0A0MSJ3;Q3HKR1 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 LDAQSLNLSQEDFDRY(0.001)MS(0.014)GQT(0.493)S(0.493)PR 105.38 8.725100000000002e-07 24900000.0 1083.0 1104.4 1362.6 1370.6 1163.9 1142.8 1012.7 713.76 734.34 887.07 True False 1108.2317928488358 975.0963345783691 1177.5664042260382 1131.2504393484396 1058.6254505032355 1131.3044695793792 936.3112236705531 694.8287661807701 1246.1213459284506 1000.9340752935143 1.1071975869378385 0.9741863711577923 1.176467495005331 1.1301947523534068 1.0576375374100475 1.1302487321631398 0.9354374546555314 0.6941803494670898 1.2449584609885895 1.0 9.967131241474206 -7.268383739079037 24.022414788160653 0.9431590773904391 1.093921982263596 0.16654417032060698 0.13477474615440896 494.06067933961236 1709077.1714801164 0.053308166928182514 0.03688185096451288 5.3903412585357896e-08 7.268383739079037 0.1507629048731568 LDAQSLNLSQEDFDRYMSGQTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LDAQSLNLSQEDFDRYMSGQTSPR 24 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;A0A0A0MSJ3;Q3HKR1 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 LDAQSLNLS(0.008)QEDFDRY(0.112)MS(0.125)GQT(0.21)S(0.546)PR 48.788 0.027089 5326700.0 5740.3 8197.0 8771.9 8975.9 9047.1 5805.8 5544.5 4333.4 4842.7 10691.0 True False 5421.27710624157 8825.683542490808 8207.52550412259 7753.366935708845 7910.522415899807 6605.496250194991 5802.330236218319 4346.00947656701 5811.37531634343 10382.32305144609 0.5221641707138437 0.8500682842132843 0.7905288116592957 0.746785367522245 0.7619221995599529 0.6362252664903306 0.5588662775630111 0.41859701870494975 0.5597374775902393 1.0 13.34184166330574 -6.897767342787433 3.9332176324765267 0.5868911895876869 0.7443913913998738 0.05396905421186016 0.16240666844351948 0.4055376020758629 11.760741690552699 0.057233697785690624 0.049985508589846336 1.2654140647260644e-07 6.897767342787433 0.15750020181218682 LDDGHLNNSLS(ph)SPVQADVYFPR ddPTM_A459_Selumetinib_30min_R1 1 LDDGHLNNSLSSPVQADVYFPR 22 0 F8WF17;B9A055;U3KQ88;Q3ZCW2 F8WF17 LGALSL Galectin;Galectin-related protein 1 LDDGHLNNSLS(0.983)S(0.017)PVQADVYFPR 263.95 1.3816999999999994e-54 24551000.0 2916.0 3424.1 3665.2 4398.5 3965.5 2760.3 3989.5 2899.2 1237.2 2495.3 True False 2983.937126451713 3023.2047801790973 3167.485971502479 3630.384545070855 3606.82122516589 2732.5338881518737 3688.568803035123 2822.303798071185 2099.4380384871847 2815.596061280288 1.0597887841535332 1.0737352640010467 1.1249788331008612 1.2893840117889894 1.2810151551092248 0.9704992579473048 1.3100489994853464 1.002382350537828 0.7456460347272056 1.0 11.459224657632847 -7.994163697672656 13.106959815303824 0.8731901834548631 1.1564606480400292 0.4886679612725833 0.11869364561123312 0.3546469459754204 791.4546179482993 0.06565982886319172 0.030687026023505374 1.0135292863440232e-08 7.994163697672656 0.28327046458516614 LDDGHLNNSLS(ph)SPVQADVYFPR ddPTM_A459_Selumetinib_30min_R2 2 LDDGHLNNSLSSPVQADVYFPR 22 0 F8WF17;B9A055;U3KQ88;Q3ZCW2 F8WF17 LGALSL Galectin;Galectin-related protein 1 LDDGHLNNSLS(0.905)S(0.095)PVQADVYFPR;LDDGHLNNSLS(0.943)S(0.057)PVQADVYFPR 304.56 1.589899999999999e-107 23078000.0 27037.0 27155.5 29523.0 32111.0 37530.0 22644.4 28071.0 30155.0 29753.0 34218.0 True False 25534.391777686422 29238.23953130525 27623.522322211957 27737.42640543532 32815.14587754306 25763.460554603214 29376.35712163125 30242.746057571017 35704.43136827928 33230.03743095895 0.7684129706666283 0.8798738067043307 0.8312817094956488 0.8347094541516703 0.9875145625617213 0.7753063958513793 0.8840302146112721 0.9101026780486017 1.074462568465693 1.0 15.020200297659997 -8.065769040425304 2.969563347377874 1.03627826243051 0.854014663606593 0.5883229487770962 0.06100862233414587 0.18569949387589121 3.053113321132044 0.04664821530550972 0.015809976195877228 8.594704698883012e-09 8.065769040425304 -0.18226359882391707 LDDGHLNNSLSS(ph)PVQADVYFPR ddPTM_A459_Selumetinib_30min_R2 2 LDDGHLNNSLSSPVQADVYFPR 22 0 F8WF17;B9A055;U3KQ88;Q3ZCW2 F8WF17 LGALSL Galectin;Galectin-related protein 1 LDDGHLNNSLS(0.432)S(0.568)PVQADVYFPR;LDDGHLNNSLS(0.071)S(0.929)PVQADVYFPR 200.2 1.4006e-22 8374800.0 20977.8 20839.0 23664.0 24588.4 28012.1 18291.2 20196.5 20173.3 18113.5 24355.2 True False 19811.937856787 22437.284292053908 22141.484003415106 21239.417502644133 24492.969566648662 20810.64676901833 21135.677268605523 20232.00096313039 21736.706133476513 23652.002093590847 0.8376431635001244 0.9486420728050713 0.9361357197501239 0.897996601666103 1.0355558683670885 0.8798682955747557 0.8936104937320638 0.855403313557663 0.9190218251911395 1.0 14.529674689466866 -5.793980829006026 0.005057757807429576 1.8260099671342365 1.1968129362083029e-07 0.08328361013548902 0.056302662824302546 79060.84089395168 90.82702572742978 15987.587926537131 16807.28993861948 1.6070121895370992e-06 5.793980829006026 -1.826009847452943 LDDQES(ph)PVYAAQQR ddPTM_A459_Selumetinib_30min_R2 2 LDDQESPVYAAQQR 14 0 Q96ST3;H3BMA2;H3BT34;H3BQ76;H3BQ88;H3BNA0;H3BNZ3;H3BQL7;H3BP90 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 LDDQES(0.985)PVY(0.015)AAQQR;LDDQES(1)PVYAAQQR 170.47 0.0001588 9030000.0 36400.0 30966.0 37696.0 41120.0 47983.0 38471.0 43779.0 46325.0 43116.0 35313.0 True False 34377.03372074514 33340.9926286166 35270.68040030153 35519.385064043476 41954.94656653738 43770.03104503279 45814.810246442794 46459.79808048343 51740.40476169563 34293.42193580728 1.0024381289535458 0.9722270554109911 1.0284969655790999 1.0357492212509745 1.2234109108467348 1.2763389762317816 1.3359649652986516 1.3547728823169056 1.5087559607946615 1.0 15.065644248929553 -6.374241374680034 1.577588099404797 1.3268985699393874 0.9918837779565913 0.5580485725132007 0.11977253820695447 0.25786745946181905 1.2842736551727139 0.043307148769746416 0.053634488077470656 4.224337663456256e-07 6.374241374680034 -0.33501479198279605 LDDS(ph)SEAK ddPTM_A459_Selumetinib_30min_R2 2 LDDSSEAK 8 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 LDDS(0.959)S(0.041)EAK;LDDS(0.965)S(0.035)EAK 100.69 0.017641 8023700.0 36178.0 22053.0 28928.0 31300.0 31857.0 46231.0 110052.0 230290.0 66694.0 71415.0 True False 34167.37159200873 23744.394188428672 27066.803974424955 27036.886004488348 27854.83885480655 52598.900606766445 115169.63606390108 230960.1057734381 80034.6635860592 69353.06339154627 0.4926584338331265 0.3423697963329328 0.39027553579881574 0.3898441493758729 0.40163819004715934 0.7584221667298109 1.6606279583309593 3.330207700696762 1.1540177127318498 1.0 16.081671988733987 -7.241925043958319 3.1546787554441593 2.0162729693667814 0.4164387301683721 0.5382772363648731 0.5977957215812248 0.16995522336295435 3.4751628811937465 0.24792422841554526 0.1730775132683998 5.728948999106431e-08 7.241925043958319 -1.5998342391984093 LDDS(ph)SEAKGPEDYPEEGVEESSGEASK ddPTM_A459_Selumetinib_30min_R2 1 LDDSSEAKGPEDYPEEGVEESSGEASK 27 1 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 LDDS(0.495)S(0.495)EAKGPEDY(0.005)PEEGVEES(0.002)S(0.003)GEASK 41.475 0.047173 2756400.0 9127.2 7775.6 7785.0 9776.4 8802.6 8059.6 11170.0 11904.0 6426.0 6915.4 True False 8619.946763076505 8371.963517505374 7284.121575667114 8444.837454769318 7696.738691757544 9169.736742235613 11689.427132935107 11938.63866918671 7711.379557441697 6715.734433632985 1.2835449120660665 1.2466192045322473 1.084635142686345 1.2574704283237934 1.1460754989374808 1.3654108620365881 1.7406029449874363 1.7777115499679326 1.148255583011507 1.0 12.713329466268794 -6.970910290510561 6.0599686656899 1.491442713782924 1.2057326271215159 0.13374940328815388 0.23069890336929166 0.24553108152651995 27.56167919870799 0.08115958309593116 0.0702062657696989 1.0692757299984743e-07 6.970910290510561 -0.2857100866614082 LDEGT(ph)PPEPK ddPTM_A459_Selumetinib_30min_R1 4 LDEGTPPEPK 10 0 H0YMT1;A0A1B0GVU7;Q9Y4G6;H0YN01 H0YMT1;H0YN01 TLN2 Talin-2 1 LDEGT(1)PPEPK;LDEGT(1)PPEPK;LDEGT(1)PPEPK;LDEGT(1)PPEPK 137.4 0.004094400000000001 199934600.0 29423.5 32838.2 24957.7 27897.5 27135.6 24268.2 27257.1 27680.9 16851.1 25681.1 True False 30109.010301835413 28993.488277934975 21568.581422832976 23025.725325932515 24681.189771179277 24024.08394176261 25201.07500218288 26946.712611764848 28595.08594435128 28977.51934009746 1.0390471989150658 1.0005510802236068 0.7443211811781137 0.7946065036033231 0.851735770805848 0.8290593704658298 0.8696767555016709 0.9299178544409598 0.9868024108186173 1.0 14.822646475861797 -8.04649272138349 2.3124046593739203 0.9965193856119262 0.8693613025405003 0.24101403149634337 0.08323956485338885 0.49367888083046163 4.82785367735107 0.07676997978656153 0.025285607545290748 8.984776506009686e-09 8.04649272138349 -0.12715808307142595 LDEGT(ph)PPEPK ddPTM_A459_Selumetinib_30min_R2 4 LDEGTPPEPK 10 0 H0YMT1;A0A1B0GVU7;Q9Y4G6;H0YN01 H0YMT1;H0YN01 TLN2 Talin-2 1 LDEGT(1)PPEPK;LDEGT(1)PPEPK;LDEGT(1)PPEPK;LDEGT(1)PPEPK 122.55 0.010362 237340000.0 1831570.0 1712510.0 1621850.0 2009180.0 1854080.0 1412780.0 1908190.0 1729560.0 1334650.0 1619630.0 True False 1729778.6717556352 1843854.0104124618 1517501.9367367632 1735526.2179711773 1621153.8947144954 1607377.6210600582 1996924.6160067527 1734592.733255927 1601617.2932367828 1572867.0735958861 1.0997615124595481 1.1722885178065594 0.9647998627547417 1.103415696790842 1.0306998740893063 1.021941172298352 1.269607997732057 1.1028222043521478 1.0182788616555931 1.0 20.584965319945965 LDFIESDS(ph)PCSSEALSK ddPTM_A459_Selumetinib_30min_R1 2 LDFIESDSPCSSEALSK 17 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 LDFIES(0.025)DS(0.891)PCS(0.025)S(0.037)EALS(0.022)K;LDFIESDS(0.997)PCS(0.003)SEALSK 252.47 4.457099999999998e-80 4385900.0 2310.6000000000004 2387.2 2133.8 2211.37 2339.3 1937.3899999999999 2436.6 2039.7600000000002 764.47 1913.11 True False 2364.4324843550517 2107.7055142208287 1844.04168012441 1825.195742056004 2127.71072803696 1917.9016156093753 2252.8053002820857 1985.6589387257457 1297.249755320319 2158.67630376946 1.0953159027253425 0.9763879422497822 0.8542465013880784 0.8455161799241807 0.9856552945532278 0.8884618839148574 1.0436049612201044 0.919850250479151 0.6009468640828983 1.0 11.075931210302244 -8.026274791416348 24.868449896202314 0.7871150937060813 0.9493317624146014 0.21327792564697645 0.11651302857660203 972.597309704698 920533.2965773611 0.07456744101898571 0.028397943533916822 9.412938226375014e-09 8.026274791416348 0.16221666870852003 LDFIESDS(ph)PCSSEALSK ddPTM_A459_Selumetinib_30min_R2 1 LDFIESDSPCSSEALSK 17 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 LDFIESDS(0.999)PCSSEALSK 188.58 2.4562e-14 0.0 6114.0 5004.5 8173.6 7554.8 6809.0 4892.8 5888.0 6544.7 5590.4 4749.0 True False 5774.2083562812 5388.329057996248 7647.719474742798 6525.823207243085 5953.592546767671 5566.738787583806 6161.803666850657 6563.743993466587 6708.636208826956 4611.884030616167 1.2520280904612733 1.168357448328193 1.658263612869084 1.415001583717448 1.290924166185559 1.2070422306000756 1.3360708174675011 1.4232239904327435 1.4546411324073676 1.0 12.17114052042747 -6.27282377280285 23.038497165856935 1.3051021989478546 1.3791123754012578 0.05453220710922502 0.16731985572412356 1035.6255899239784 2095778.8962780514 0.05341118531602462 0.061181830897906464 5.335513550316188e-07 6.27282377280285 0.07401017645340313 LDFIESDSPCSS(ph)EALSK ddPTM_A459_Selumetinib_30min_R1 1 LDFIESDSPCSSEALSK 17 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 LDFIES(0.021)DS(0.121)PCS(0.06)S(0.773)EALS(0.026)K 94.544 0.0067532 5594400.0 981.91 1113.8 1106.9 1219.4 1249.2 940.99 1351.6 1083.9 829.24 1280.7 True False 1004.7865925357345 983.395778208428 956.5890597664774 1006.4546809729225 1136.210080564173 931.52449495056 1249.6477238205978 1055.1514509966048 1407.1597147066866 1445.090320074406 0.6953105827212234 0.6805081762348212 0.6619579734761656 0.69646489703225 0.7862554089391941 0.6446133380110088 0.8647540617089282 0.7301629775931765 0.9737520867444698 1.0 10.496943950572302 -8.126109667209803 0.7538880745473496 1.0114939524950517 0.6887350080250205 0.7470238117597641 0.06191198898166177 0.2931996780565314 0.35159950974011595 0.05484033730335657 0.022752623454289606 7.479805980351617e-09 8.126109667209803 -0.3227589444700312 LDFLPEMMVDHCSLNSS(ph)PVSK ddPTM_A459_Selumetinib_30min_R1 2 LDFLPEMMVDHCSLNSSPVSK 21 0 F5H3J7;F5H0D8;E9PKU1;Q92879-4;G5EA30 F5H3J7 CELF1 1 LDFLPEMMVDHCS(0.049)LNS(0.212)S(0.731)PVS(0.008)K;LDFLPEMMVDHCS(0.114)LNS(0.178)S(0.703)PVS(0.005)K 129.29 3.74e-05 209675000.0 6692.38 7178.900000000001 6063.71 7693.83 14450.1 7361.9400000000005 11149.1 7007.3 2000.97 3880.88 True False 6848.299432895383 6338.391050619934 5240.291487574836 6350.247021576098 13143.09100637236 7287.885567706699 10308.114410808092 6821.44364108175 3395.4999449334814 4379.028750972404 1.563885469209275 1.4474422094653832 1.196678940829329 1.4501496525150621 3.0013712523476386 1.6642698603173949 2.3539727635994807 1.5577526499607899 0.7754002401056351 1.0 12.096395206649303 -8.142930048922803 4.420957712496772 0.8974373930150542 1.8082628026800995 0.34727350015038483 0.49723771007769624 0.2716798304762089 8.292399823801793 0.39212616201005374 0.13700614748667664 7.195648677658186e-09 8.142930048922803 0.9108254096650453 LDGLVET(ph)PTGYIESLPR ddPTM_A459_Selumetinib_30min_R1 7 LDGLVETPTGYIESLPR 17 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 LDGLVET(0.955)PT(0.042)GYIES(0.002)LPR;LDGLVET(0.999)PT(0.001)GYIESLPR;LDGLVET(1)PTGYIESLPR;LDGLVET(0.879)PT(0.12)GYIES(0.001)LPR;LDGLVET(0.959)PT(0.041)GYIES(0.001)LPR;LDGLVET(1)PTGYIESLPR;LDGLVET(0.935)PT(0.065)GYIESLPR 204.9 3.2752e-08 339778700.0 17495.920000000002 25547.799999999996 22761.550000000003 26318.16 20432.77 22298.329999999998 22414.329999999994 18948.1 13365.49 16468.63 True False 17903.540894865942 22556.651699150003 19670.656530244534 21722.187409048987 18584.629561198537 22074.029045463747 20723.599042219386 18445.534835897015 22680.26035323318 18582.539078540623 0.963460419439731 1.2138627344633834 1.0585559081622211 1.1689569071932733 1.0001124971484832 1.1878908986638508 1.1152189135526311 0.9926272592747122 1.2205146055322798 1.0 14.181660021514762 -10.636785172467118 4.636603075886818 0.9999919790348226 1.1029654573172034 0.10307325330622352 0.09056515366011172 6.814594209188551e-06 1.3023907652798881e-06 0.07957907557390906 0.019299257672585304 2.3078885234897928e-11 10.636785172467118 0.10297347828238079 LDGLVET(ph)PTGYIESLPR ddPTM_A459_Selumetinib_30min_R2 5 LDGLVETPTGYIESLPR 17 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 LDGLVET(0.998)PT(0.002)GYIESLPR;LDGLVET(0.98)PT(0.019)GYIES(0.001)LPR;LDGLVET(0.989)PT(0.01)GYIES(0.001)LPR;LDGLVET(0.835)PT(0.156)GY(0.001)IES(0.007)LPR;LDGLVET(0.83)PT(0.17)GYIESLPR 152.68 0.00070084 559822000.0 123019.95999999999 109670.0 125245.3 131393.69 130014.2 115931.4 91255.2 121283.87 89936.27 129301.1 True False 116183.00311111858 118081.33635537003 117187.153754772 113497.64275524244 113680.65385430481 131899.89802953188 95498.74761874827 121636.78598207445 107926.03702934283 125567.84127839615 0.9252608146183666 0.9403788036267359 0.9332576921104876 0.9038750813881327 0.9053325492971063 1.0504273760436553 0.7605350752747133 0.9686937733714306 0.8595038023315243 1.0 16.938107502609597 -7.241926416257671 24.9997466477542 0.8945742692266776 0.9390200318269878 0.08846170141234211 0.07128163578671257 2146.1967319572336 2749681.7599656284 0.02567086368664237 0.01985588566721653 5.728930896595559e-08 7.241926416257671 0.04444576260031019 LDGLVETPT(ph)GYIESLPR ddPTM_A459_Selumetinib_30min_R1 1 LDGLVETPTGYIESLPR 17 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 LDGLVET(0.067)PT(0.69)GY(0.002)IES(0.241)LPR 78.902 0.042743 26951000.0 1178.3 1466.7 1574.6 1438.9 1404.1 1616.1 1330.1 1340.5 706.91 1066.2 True False 1205.7520974273168 1294.9780821496686 1360.7779686586814 1187.6231264982262 1277.0994029139893 1599.8435013013966 1229.7694861303457 1304.9455854423366 1199.5746393363854 1203.0571556674722 1.0022400779108034 1.0764061175723587 1.1311000165272311 0.9871709925862309 1.0615450786338056 1.3298150414256769 1.0222037085578475 1.0846912628339218 0.9971052777379021 1.0 10.232489469353341 -8.19863748753754 2.2490320699182194 0.9940445338924715 1.0923420384112736 0.1266340744499138 0.09133173829712031 0.6794980865997415 6.151316810112088 0.08527742992979337 0.025393088420141312 6.329399559135993e-09 8.19863748753754 0.09829750451880215 LDGLVETPTGYIES(ph)LPR ddPTM_A459_Selumetinib_30min_R1 1 LDGLVETPTGYIESLPR 17 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 LDGLVET(0.001)PTGYIES(0.999)LPR 174.87 1.7908e-07 35566000.0 3384.1 3655.3 3716.3 4089.9 3572.7 3273.1 3553.4 3118.3 2152.8 2851.6 True False 3462.9429456876687 3227.335776697133 3211.6468721746883 3375.675741931406 3249.5499158114158 3240.1755857370213 3285.364177141249 3035.592554334083 3653.1443657090313 3217.630636936188 1.076240046304714 1.0030162379887664 0.998140319559116 1.0491184734447045 1.0099201190182665 1.0070066926085404 1.0210507506447528 0.9434248044158853 1.135352306685996 1.0 11.651783008223521 LDGLVETPTGYIES(ph)LPR ddPTM_A459_Selumetinib_30min_R2 4 LDGLVETPTGYIESLPR 17 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 LDGLVETPTGYIES(1)LPR;LDGLVET(0.053)PT(0.005)GYIES(0.942)LPR;LDGLVETPTGYIES(1)LPR;LDGLVET(0.274)PT(0.009)GYIES(0.717)LPR 170.79 8.0665e-07 14712400.0 38858.1 32447.9 38840.4 45688.0 43366.2 33607.8 26733.699999999997 31136.1 30719.699999999997 36728.8 True False 36698.52236329909 34936.54959355711 36341.450950230064 39465.21558380393 37918.15025725307 38236.96938876696 27976.870021821567 31226.700896141174 36864.49838013407 35668.34411111711 1.0288821440370957 0.9794833616250799 1.0188712668302187 1.1064493339208143 1.063075710471088 1.0720141442408384 0.7843613354930523 0.8754738038542258 1.0335354583686474 1.0 15.122356620357493 -7.226144225175357 24.998043784740535 0.9129653935412125 1.0442821759881622 0.4109485853262069 0.0707994208546717 573.7121065276363 406336.2375943098 0.02779857275611613 0.021531746091814418 5.940948324604557e-08 7.226144225175357 0.13131678244694966 LDGLVETPTGYIESLPR ddPTM_A459_Selumetinib_30min_R1 1 LDGLVETPTGYIESLPR 17 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 133.98 0.0068104 0.0 892.88 952.14 1130.2 1054.7 1155.7 837.5 704.86 957.04 615.4 890.92 False True 913.6823667579582 840.6630061621225 976.7250477442157 870.5164441710189 1051.1671390554075 829.0755103891585 651.6918427139584 931.6561902959598 1044.288852962346 1005.2782602956895 0.9088850349645584 0.8362490659201687 0.9715967074200179 0.8659457570632909 1.0456479370659229 0.8247224108330928 0.648270104361226 0.9267644861054941 1.0388057657341383 1.0 9.97337917828891 -8.006771741675621 24.950820146079657 1.0071970100105996 0.8722552798822633 0.2620439755669687 0.09802620677895568 435.25987026172606 1603728.3915318279 0.06017914775841041 0.027150536057541183 9.845284224005937e-09 8.006771741675621 -0.13494173012833632 LDGSLETTNEILDS(ph)ASHDCPLVTQTYGAAAGK ddPTM_A459_Selumetinib_30min_R2 2 LDGSLETTNEILDSASHDCPLVTQTYGAAAGK 32 0 Q9Y4P8-4;Q9Y4P8;Q9Y4P8-3;Q9Y4P8-2;Q9Y4P8-5;Q9Y4P8-6 Q9Y4P8-4 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 1 LDGSLET(0.001)T(0.003)NEILDS(0.498)AS(0.498)HDCPLVTQTYGAAAGK;LDGSLET(0.004)T(0.004)NEILDS(0.495)AS(0.495)HDCPLVT(0.001)QTYGAAAGK 95.741 1.4522e-07 2307400.0 7538.8 5360.5 7136.9 7578.5 5986.1 6358.1 7606.2 6111.5 5121.799999999999 6275.9 True False 7119.82367620751 5771.633113275831 6677.719624069187 6546.2952263583065 5234.072601587012 7233.87056191477 7959.90337139937 6129.283453186713 6146.303115048997 6094.698460253531 1.1681994970939604 0.9469923985436581 1.095660378871542 1.074096654502246 0.8587910682900761 1.1869119709679372 1.3060372753975837 1.0056746027976162 1.0084671383058579 1.0 12.573339128861406 LDHDLS(ph)LDR ddPTM_A459_Selumetinib_30min_R1 1 LDHDLSLDR 9 0 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 LDHDLS(1)LDR 115.57 0.0081236 1731100.0 2205.4 2956.7 2374.7 2403.0 2603.9 3044.5 2919.6 2977.3 1557.8 2357.4 True False 2256.7815290386184 2610.5281894674627 2052.2287832933916 1983.3611598966154 2368.377704755885 3013.875094184828 2699.372221416556 2898.332332366632 2643.4728227896367 2659.995253020539 0.8484156227256217 0.9814033263792841 0.7715159570164637 0.7456258268297371 0.890369147112759 1.1330377716886686 1.0148033979952793 1.0896005656684729 0.993788548978747 1.0 11.37720795578335 -6.617841622340974 5.890207041309866 1.0488848107753408 0.8396034557614579 0.671882934476028 0.0701542839776453 0.12940428027898052 6.618291174583367 0.02421244372558329 0.024184257840487725 2.4107844285332783e-07 6.617841622340974 -0.2092813550138829 LDHDLS(ph)LDR ddPTM_A459_Selumetinib_30min_R2 1 LDHDLSLDR 9 0 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 LDHDLS(1)LDR 73.082 0.044524 0.0 3862.1 5847.0 3800.0 3852.3 5168.6 3412.3 3851.5 6130.1 4067.3 2148.3 True False 3647.459943211256 6295.446098931778 3555.512137127172 3327.6100944118343 4519.274260129736 3882.3133512246973 4030.602381602464 6147.937576107314 4880.873649857237 2086.272997046267 1.7483138344671614 3.0175562392097453 1.7042410759095503 1.5950022356245062 2.1661950600559456 1.8608846285798903 1.9319630687397897 2.9468519147836973 2.3395182014854 1.0 11.02671223720586 -5.309749811041971 24.999118599865458 2.004816707316042 2.3829426662483866 0.08198020481999957 0.5590135897720632 986.8549831950792 510664.6084422659 0.14591057785057754 0.3037380262499233 4.900610531063414e-06 5.309749811041971 0.37812595893234446 LDHEGVT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 LDHEGVTSPK 10 0 H9KVB4;O15417;H7BXS9;F8WBW8;Q9P281 H9KVB4;F8WBW8 TNRC18;BAHCC1 Trinucleotide repeat-containing gene 18 protein;BAH and coiled-coil domain-containing protein 1 1 LDHEGVT(0.92)S(0.08)PK;LDHEGVT(0.917)S(0.083)PK 141.71 0.0029908 12908100.0 111414.0 100628.0 96741.0 97594.0 92852.0 75684.0 96823.0 99536.0 64786.0 86862.0 True False 105222.05590557956 108345.84402998204 90516.78938363683 84301.52884095942 81187.10165258795 86108.78400905263 101325.46135113463 99825.63328092804 77745.01027208491 84354.06836542029 1.2473856678703334 1.2844175287507156 1.073057780586465 0.9993771548251441 0.9624562659015675 1.0208017903301467 1.2011923469084451 1.1834121959415782 0.9216509858812612 1.0 16.364170030386823 -5.296117093335982 5.640586247861833 1.050972977470176 1.2666877600811042 0.519994478160503 0.08475448119664655 0.14863380529321707 13.909248036256935 0.024005628882705465 0.053387950283955724 5.056883012715402e-06 5.296117093335982 0.21571478261092825 LDHEGVTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 LDHEGVTSPK 10 0 H9KVB4;O15417;H7BXS9;F8WBW8;Q9P281 H9KVB4;F8WBW8 TNRC18;BAHCC1 Trinucleotide repeat-containing gene 18 protein;BAH and coiled-coil domain-containing protein 1 1 LDHEGVT(0.069)S(0.931)PK;LDHEGVT(0.026)S(0.974)PK;LDHEGVT(0.007)S(0.993)PK 156.58 0.00050635 15477000.0 16512.2 19414.0 22649.7 23906.5 17629.0 17965.100000000002 16708.3 16086.2 11967.0 18038.7 True False 16896.902132851847 17140.999854676265 19573.99514589645 19731.67855558402 16034.460062652739 17784.387405005695 15447.979479070502 15659.541720658346 20307.124964901504 20354.142856817503 0.830145599925979 0.8421381325293679 0.9616713061115345 0.9694182994777896 0.7877737802789415 0.873747793267989 0.758959961504657 0.769354024427183 0.9976900087492384 1.0 14.31303484827592 -8.285551663158474 23.617409820906282 0.998845191523084 0.8524445370851038 0.4347686284611867 0.06819018916639864 471.4895798770938 461804.2143647321 0.07166513551781434 0.01855549384176746 5.18141450846081e-09 8.285551663158474 -0.14640065443798023 LDHKFDLMYAK ddPTM_A459_Selumetinib_30min_R1 1 LDHKFDLMYAK 11 1 Q9BQE3;F5H5D3;Q9NY65;Q9NY65-2;C9J2C0;V9GZ17;P68363;P68363-2;P68366-2;P68366;A6NHL2-2;A6NHL2 Q9BQE3;P68363;P68366-2;A6NHL2-2 TUBA1C;TUBA8;TUBA1B;TUBA4A;TUBAL3 Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha chain-like 3 0 79.65899999999998 0.03605 28520000.0 11066.0 14241.0 15909.0 19709.0 13689.0 12581.0 10821.0 9277.4 6536.4 8272.5 False True 11323.816269312305 12573.657099538708 13748.645181881728 16267.193133750476 12450.832366989249 12454.446562634033 10004.763257962919 9031.333214757735 11091.793400232487 9334.355955973708 1.2131331098494698 1.3470299567365378 1.4729077449722718 1.7427226056597895 1.333871605680635 1.3342587985048462 1.0718214845406844 0.9675368346091358 1.188276240219238 1.0 13.18833476869077 -7.131455710643171 2.2797821349795746 1.0471729618332208 1.4379844188207267 0.6107980063129665 0.13841707325180286 0.2231858827482833 2.2732905282942255 0.06685189580904537 0.048148845985251446 7.388296050044665e-08 7.131455710643171 0.39081145698750586 LDHLAEK ddPTM_A459_Selumetinib_30min_R2 3 LDHLAEK 7 0 O43707;O43707-2;P12814-4;P12814-3;P12814;P12814-2;H9KV75 O43707;P12814-4 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 ;; 111.65 0.020935 62797100.0 718170.0 632100.0 600620.0 681760.0 668090.0 483583.0 640380.0 763860.0 589640.0 747290.0 False True 678256.9864622941 680580.0374781551 561976.7631056119 588903.1118984025 584158.5613996207 550192.1687205978 670158.9388888971 766082.7061361704 707584.4759181315 725713.7960074014 0.9346067143739082 0.9378077710833734 0.7743779520210201 0.8114812135835383 0.8049434427365675 0.7581393267532515 0.9234479798728564 1.0556264885012014 0.9750186365630494 1.0 19.46904117074324 -7.525247369931572 5.477638723884406 1.0091371067535815 0.8359770262832878 0.634393173519369 0.05916370449657848 0.11502037315724076 11.758321285671364 0.029896509633992926 0.017976386857493903 2.9836826580725843e-08 7.525247369931572 -0.17316008047029363 LDIDS(ph)PPITAR ddPTM_A459_Selumetinib_30min_R1 13 LDIDSPPITAR 11 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(0.973)PPIT(0.027)AR;LDIDS(0.964)PPIT(0.036)AR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(0.998)PPIT(0.002)AR 221.09 6.0652e-38 81730500.0 53066.299999999996 57338.3 62760.799999999996 65575.0 59973.30000000001 51701.59999999999 55633.299999999996 52641.51 30930.1 45267.1 True False 54302.64154095495 50625.105180147526 54238.22808039744 54123.55724520201 54548.72560414613 51181.528845296816 51436.8353903732 51245.28615107697 52486.12065487595 51077.57322389326 1.0631405940710013 0.9911415516598178 1.0618795032146453 1.0596344702587375 1.0679584436213803 1.002035249814001 1.007033657705411 1.0032834944301006 1.0275766318185962 1.0 15.640402361500334 -6.775603568970789 24.99954851908439 1.0081315079858066 1.0468844017749337 0.4676573959522742 0.02170062386958243 238.04124088750038 420136.4930104138 0.007850285395498788 0.006955478560893065 1.6764724890028635e-07 6.775603568970789 0.03875289378912705 LDIDS(ph)PPITAR ddPTM_A459_Selumetinib_30min_R2 8 LDIDSPPITAR 11 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(1)PPITAR;LDIDS(0.952)PPIT(0.048)AR 181.98 3.9062e-05 68369000.0 687209.6 587240.8 688584.8 750527.2 787688.0 546746.4 579140.7999999999 590999.4 514751.10000000003 627519.0 True False 649017.2415499941 632280.2810832163 644282.0036424447 648304.1006283648 688731.5914199343 622055.7537303407 606071.9947457248 592719.1104087821 617715.7033474359 609400.8959798341 1.0650086762778093 1.0375440621343281 1.0572383596622819 1.0638384434699257 1.130178173290256 1.0207660635781628 0.9945374198560097 0.9726259254275793 1.0136442322655805 1.0 19.217032095604488 -6.989214845171802 24.90927648924384 0.9950251460949702 1.068549424014317 0.6900908136844864 0.02407382004636965 124.7614613789706 288146.4837169929 0.008901980278909668 0.007843890193409383 1.0251446624536781e-07 6.989214845171802 0.07352427791934679 LDIDSPPIT(ph)AR ddPTM_A459_Selumetinib_30min_R1 3 LDIDSPPITAR 11 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 LDIDSPPIT(1)AR;LDIDSPPIT(1)AR;LDIDSPPIT(1)AR 163.71 0.0015011 27709200.0 5062.799999999999 7499.1 7893.5 7498.0 6878.700000000001 6401.5 6784.5 6536.7 2951.5 4843.8 True False 5180.753389506085 6621.101885762997 6821.606055891852 6188.6150548917285 6256.522799533126 6337.106722096954 6272.73970276771 6363.325481805982 5008.479930969068 5465.548912607484 0.9478926037155287 1.2114248708835038 1.2481099638787103 1.1322952467987861 1.144719935650212 1.1594639117544134 1.147687049016845 1.1642610071840322 0.9163727213959998 1.0 12.416150679686236 -8.256284452891142 24.659529036655776 0.9581863501886513 1.150375496904692 0.48607814996723175 0.07643079031749032 258.1965261675758 1235148.0395966384 0.05399478431744707 0.01900807742893724 5.5426256481945304e-09 8.256284452891142 0.1921891467160407 LDIDSPPIT(ph)AR ddPTM_A459_Selumetinib_30min_R2 2 LDIDSPPITAR 11 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 LDIDS(0.018)PPIT(0.982)AR;LDIDSPPIT(1)AR 155.88 0.001263 8503900.0 75619.0 74067.0 83712.0 82964.0 78454.0 56524.0 62476.0 68669.0 50985.0 70633.0 True False 71416.39870684133 79747.70073705846 78326.06105873408 71664.16007911741 68597.90713234109 64309.66792621543 65381.25779384543 68868.81542123506 61183.42463992605 68593.64176342636 1.04115187458847 1.1626106835397587 1.1418851521089084 1.0447638911822323 1.0000621831529144 0.9375456131635933 0.9531679046775184 1.0040116496330338 0.8919693293285473 1.0 16.06578723260202 -6.145829289608411 2.0649114194943645 0.9588163745039008 1.1191587616038143 0.7142204790982669 0.043070504630574005 0.16375316556923453 1.3741855815569726 0.013823103928817963 0.01950202036946544 7.147772320688243e-07 6.145829289608411 0.16034238709991355 LDIDSPPITAR ddPTM_A459_Selumetinib_30min_R1 2 LDIDSPPITAR 11 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 133.75 0.024382 33447000.0 3728.3 5158.5 5074.5 5069.9 4873.0 4278.1 4997.6 4374.7 2913.6000000000004 3721.2000000000003 False True 3815.1621359910605 4554.5404218784115 4385.4107722332565 4184.537138809755 4432.238010398029 4235.06619820401 4620.627008409155 4258.668744971718 4944.166399075544 4198.8522675574895 0.9086202354555272 1.0847108046808775 1.0444308331867769 0.9965907043554876 1.0555832232164486 1.008624721314043 1.1004500072818746 1.0142459114068865 1.1775042521206898 1.0 12.035779313937285 -7.252202680279656 24.04903882466438 1.0742372025726 1.021681686238719 0.1593725288681188 0.06299504343526735 767.8299867671541 1999155.8188021665 0.02285712798258739 0.01745275689494597 5.594964299566307e-08 7.252202680279656 -0.05255551633388089 LDIDSPPITAR ddPTM_A459_Selumetinib_30min_R2 1 LDIDSPPITAR 11 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 135.55 0.020618 16479000.0 28504.0 26832.0 34477.0 34502.0 38394.0 26061.0 27872.0 28126.0 24184.0 27152.0 False True 26919.861790552714 28889.9281215217 32258.787355719323 29802.768080730246 33570.602473285064 29650.666191796405 29168.103227320244 28207.84200349006 29021.47575741829 26368.05121063175 1.020927241665037 1.0956413839894665 1.2234043046272753 1.1302605506437122 1.2731544779368906 1.124492134626964 1.106191086869533 1.0697734837573623 1.100630286462606 1.0 14.686503329111796 -8.294377680276614 0.8831423991219782 1.0091938219330796 1.1481872156795192 0.28261900314406796 0.06661794354223098 0.7459978152302913 1.2494146920199123 0.06626934697497698 0.02415673824004658 5.077177183861123e-09 8.294377680276614 0.1389933937464396 LDIPTGTT(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 LDIPTGTTPQR 11 0 P52732 P52732 KIF11 Kinesin-like protein KIF11 1 LDIPTGT(0.007)T(0.993)PQR 148.13 0.0015302 12871000.0 5078.7 7295.0 3278.5 3596.7 4577.3 4605.8 6279.0 4882.4 2191.5 5488.2 True False 5197.023828570072 6440.898008646507 2833.297707511425 2968.60386342079 4163.284023187952 4559.469833731806 5805.369974748095 4752.902891729703 3718.8154391728617 6192.663929595029 0.8392226491951634 1.0400851849662236 0.45752486163038225 0.47937428821765926 0.6722929050438897 0.7362695417624534 0.9374592325289868 0.7675053814910509 0.6005194987896032 1.0 12.596344439055567 -7.01031503030603 22.690417919322197 0.8112633152827934 0.692552269703282 0.0955644736621295 0.18473201202414202 441.0654146975293 970232.6723014853 0.07330657561072876 0.06073874918342972 9.765286056671866e-08 7.01031503030603 -0.1187110455795114 LDIS(ph)QDDSEITQMEHNLASR ddPTM_A459_Selumetinib_30min_R1 1 LDISQDDSEITQMEHNLASR 20 0 D6RCC7;Q9P2D6-3;Q9P2D6-2;Q9P2D6-4;Q9P2D6 D6RCC7 FAM135A Protein FAM135A 1 LDIS(1)QDDSEITQMEHNLASR 153.87 2.9276e-07 0.0 189.88 298.98 234.09 397.11 275.25 363.35 223.74 357.8 0.0 245.51 True False 194.30383455783655 263.97528260796884 202.30186376432806 327.7621931779214 250.35368609933454 359.69502889540377 206.8631116658926 348.3099817018041 0.0 277.0235999699129 0.7013981284588735 0.9528981741506456 0.7302694203176183 1.1831562120105261 0.903726924805414 1.2984273864554128 0.74673461643109 1.2573296345135703 0.0 1.0 8.113865076190853 -8.244382371687669 24.93311055040437 0.4999997965813199 0.9712344640207464 0.27903566369973176 0.30331274664146857 815.6217709950364 1192241.4698131708 0.18839355123871365 0.07080927880160956 5.696624958652128e-09 8.244382371687669 0.47123466743942655 LDLAGTLPGS(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 LDLAGTLPGSKR 12 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 LDLAGTLPGS(1)KR 81.327 0.019739 6287800.0 43851.0 43807.0 45872.0 38119.0 31866.0 28920.0 32946.0 33606.0 30399.0 48505.0 True False 41413.93696946141 47166.85603829389 42920.64546165729 32927.12644105721 27862.708194345516 32903.46749037844 34478.05428126052 33703.78789622721 36479.64941902742 47104.53461887501 0.8791921479437915 1.00132304500879 0.9111786329900132 0.69902243398586 0.5915079815517548 0.6985201691642202 0.7319476683131266 0.7155104740748662 0.774440289330655 1.0 15.52357833019982 -5.7092554564703875 5.562717199324246 0.7237096647733458 0.9420069648229775 0.3980549320043597 0.10279627149385898 0.16333049226379978 10.822087651357785 0.027027608627203662 0.04672496063957745 1.953190231280722e-06 5.7092554564703875 0.21829730004963177 LDLDTDSADGLSAPLLAS(ph)PEPSAGPLQVAAPAHSHAGGPGPTEHA ddPTM_A459_Selumetinib_30min_R2 1 LDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA 45 0 Q15528 Q15528 MED22 Mediator of RNA polymerase II transcription subunit 22 1 LDLDTDS(0.001)ADGLS(0.016)APLLAS(0.477)PEPS(0.477)AGPLQVAAPAHS(0.028)HAGGPGPT(0.002)EHA 46.096 0.0016324999999999998 2807400.0 1273.1 440.34 1079.3 1060.5 574.25 1426.9 863.87 1127.3 692.15 899.85 True False 1202.3461986230934 474.112662083738 1009.8590130529889 916.0580705354598 502.1075811398644 1623.4425228914592 904.0416667259309 1130.5802563654388 830.5993402868457 873.8689924089201 1.3758883872383298 0.542544324380697 1.1556183155889268 1.0482784931071196 0.574579926169193 1.8577641923376338 1.034527686162472 1.29376401518592 0.9504849668566491 1.0 9.771273201573031 -6.713305092140883 24.999998612188996 1.2336320504377651 0.9353991645097745 0.1574731547526721 0.3327692470808707 212.1702930280772 110196.24759807765 0.10440763545002602 0.10440739267935774 1.9350621040320394e-07 6.713305092140883 -0.2982328859279907 LDLLGNLPGS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 LDLLGNLPGSK 11 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 LDLLGNLPGS(1)K;LDLLGNLPGS(1)K 98.694 0.017994 22910000.0 7147.1 13276.6 10017.6 11225.0 7417.5 8963.9 9662.4 8534.6 5910.4 8886.5 True False 7313.613524164282 11722.16949987611 8657.264942737973 9264.76446934644 6746.5884346659905 8873.731304569998 8933.55738875713 8308.234683712179 10029.517121463512 10027.168836840168 0.729379712575878 1.1690408021064183 0.863380789094812 0.9239661384086176 0.6728308403343912 0.8849687732361301 0.8909351716443558 0.8285723337167151 1.000234192189396 1.0 13.291626699195978 -10.574156682188308 15.650143485112658 0.9999999928019382 0.8859888561312832 0.06614794187936668 0.1297723879689805 0.0 0.0 0.12249260386971277 0.029708820020520773 2.6658967045994696e-11 10.574156682188308 -0.11401113667065499 LDLLGNLPGS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 LDLLGNLPGSK 11 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 LDLLGNLPGS(1)K;LDLLGNLPGS(1)K 115.83 0.005123 2540200.0 53262.0 65713.0 51810.0 53568.0 44049.0 55089.0 46893.0 57753.0 40650.0 63092.0 True False 50301.9112646793 70752.975799402 48476.601006462806 46271.945990045715 38515.1708169436 62677.009701848474 49073.617416716734 57921.051668476175 48781.135855898654 61270.370027297446 0.8209826583757952 1.1547665824097328 0.7911915822422044 0.7552091813617322 0.6286100573537283 1.0229579105516147 0.8009355483711497 0.9453354311826571 0.7961619267872132 1.0 15.902901943692095 -5.300133976653063 24.999634813635474 0.8347947396976623 0.9878749672482179 0.15327464182747674 0.1356500835749221 803.9613928673149 519418.5551616124 0.034530923741162 0.07188422700940764 5.010326448983241e-06 5.300133976653063 0.15308022755055561 LDLTGPHFESSILS(ph)PCEDVTLTK ddPTM_A459_Selumetinib_30min_R2 1 LDLTGPHFESSILSPCEDVTLTK 23 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 LDLTGPHFES(0.083)S(0.02)ILS(0.896)PCEDVT(0.001)LTK 73.934 0.0007117000000000001 2948300.0 16970.0 14075.0 16225.0 22248.0 18103.0 13852.0 18842.0 16094.0 15333.0 16593.0 True False 16026.875336292444 15154.507241741876 15181.101164444295 19217.784020059313 15828.739297126607 15759.98726406369 19718.190334714705 16140.830875494867 18400.028439815364 16113.916976208497 0.9945983561883454 0.9404607994516078 0.9421111692990932 1.1926202703187276 0.9823023986344883 0.9780357741282043 1.2236745642805384 1.0016702270047753 1.1418718656042608 1.0 13.976019607006215 -5.7090567114038455 24.9999585632811 1.0727592357478692 0.9571968026709963 0.280939192357164 0.08445579423523836 128.13940244691827 61154.187202553825 0.022208471269301342 0.038466155078157586 1.9540842692542772e-06 5.7090567114038455 -0.11556243307687297 LDNS(ph)PNMNITQPSK ddPTM_A459_Selumetinib_30min_R1 2 LDNSPNMNITQPSK 14 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 LDNS(0.999)PNMNIT(0.001)QPSK;LDNS(0.619)PNMNIT(0.381)QPSK 205.98 9.806499999999999e-30 5350500.0 4217.9 5470.6 4945.7 5710.4 5043.4 4573.6 5379.6 4791.1 2685.2 4340.6 True False 4316.168863395299 4830.099608787058 4274.101104785499 4713.185837483822 4587.22536048459 4527.593736496542 4973.812440859191 4664.0244643138985 4556.588280751529 4897.758291024412 0.8812539547541722 0.986185785778497 0.8726647684141904 0.9623149117262819 0.9365969261674465 0.9244216368933048 1.0155283591626307 0.9522773863424718 0.9303415991560654 1.0 12.257905861964362 -7.188063368740092 24.999441858703612 0.9705611006847062 0.9294579598709732 0.26328138536347867 0.03842351038318651 213.82402109964266 72849.73358021166 0.013955604239884558 0.010809964145147823 6.485397969595331e-08 7.188063368740092 -0.04110314081373301 LDNS(ph)PNMNITQPSK ddPTM_A459_Selumetinib_30min_R2 4 LDNSPNMNITQPSK 14 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 LDNS(1)PNMNITQPSK;LDNS(1)PNMNITQPSK;LDNS(1)PNMNITQPSK;LDNS(0.781)PNMNIT(0.219)QPSK 220.42 7.7403e-09 39740500.0 258339.0 233357.0 271407.0 278555.0 299297.0 211430.0 219851.0 241032.0 208298.0 254343.0 True False 243981.55259295518 251254.7315389809 253944.96910559887 240615.3284658224 261696.63511087123 240552.5633295545 230074.50712649184 241733.36321500415 249963.4203323985 246999.4567275234 0.987781737763507 1.0172278711371892 1.028119545160528 0.9741532700262429 1.0595028773668964 0.9738991596038985 0.9314777861244357 0.9786797364565522 1.0119998790448548 1.0 17.914148343059033 LDNSPNMNIT(ph)QPSK ddPTM_A459_Selumetinib_30min_R1 1 LDNSPNMNITQPSK 14 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 LDNS(0.143)PNMNIT(0.857)QPSK 204.23 2.3244e-29 0.0 1981.0 2207.3 2548.5 2098.8 2256.9 1775.1 2291.6 2300.5 1054.6 1436.5 True False 2027.1534456450086 1948.8682898540694 2202.427697908453 1732.2839793553965 2052.7637934880577 1757.244105661845 2118.742767022256 2239.483266922861 1789.5791750635196 1620.8887676949205 1.2506431570426886 1.2023454839690026 1.3587778148654481 1.0687247724092086 1.266443345404454 1.0841238095324928 1.307148774949769 1.3816390807048708 1.1040727844690388 1.0 10.662569375023393 -8.518592171753692 23.565133367389898 0.9999999908858196 1.235400467193009 0.3947274701294623 0.0973188408526944 140.34011034128983 771505.7263427124 0.09220573392056723 0.023807418136800276 3.0297572141588167e-09 8.518592171753692 0.2354004763071894 LDNT(ph)PASPPRS(ph)PAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R1 2 LDNTPASPPRSPAEPNDIPIAK 22 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 2 LDNT(0.85)PAS(0.293)PPRS(0.857)PAEPNDIPIAK;LDNT(0.996)PAS(0.02)PPRS(0.984)PAEPNDIPIAK 85.595 0.0020873000000000003 71469000.0 17800.2 23766.0 15812.5 16893.7 17041.0 16731.1 24940.0 23315.5 12321.099999999999 19204.4 True False 18214.910026840123 20983.465671486338 13665.249351845177 13943.53242902432 15499.644558832917 16562.800324623335 23058.755720690806 22697.097200582484 20908.00680246077 21669.471806697045 0.8405793269594474 0.9683422770370114 0.6306221708469087 0.6434643425279527 0.7152756051046285 0.7643379807487752 1.0641124955138221 1.047422724607798 0.9648600108471062 1.0 14.403376367722805 -7.254614805128289 23.56639075388395 1.0230507068312324 0.7566167681405059 0.6444137654975932 0.09408601675781483 168.65613991862597 582399.5912481272 0.0406409900974243 0.030708360779707962 5.5639753192016014e-08 7.254614805128289 -0.2664339386907265 LDNT(ph)PASPPRSPAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R1 2 LDNTPASPPRSPAEPNDIPIAK 22 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 LDNT(0.333)PAS(0.333)PPRS(0.333)PAEPNDIPIAK;LDNT(0.697)PAS(0.116)PPRS(0.187)PAEPNDIPIAK 77.241 0.0022033 85796500.0 7372.700000000001 8239.7 5293.7 6880.1 6711.6 5220.9 5399.3 4249.3 2016.12 5937.700000000001 True False 7544.469565223102 7274.992093467394 4574.8446162126675 5678.619690472201 6104.536965029221 5168.382486197921 4992.026453998634 4136.594760328326 3421.2083884212593 6699.861633095806 1.1260634888271608 1.0858421400123508 0.6828267308706745 0.8475726815642133 0.9111437368906524 0.7714163021915672 0.7450939627378496 0.6174149537498625 0.5106386632704862 1.0 12.709915585708945 -2.6436858078438283 0.48729540171513075 0.7147611250438309 4.821555663647612 0.44024705684864207 0.1435985708677614 29.56718894550913 0.9730774805620439 0.08364288049208836 107.71087012534707 0.0022715075892388633 2.6436858078438283 4.106794538603781 LDNT(ph)PASPPRSPAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R2 2 LDNTPASPPRSPAEPNDIPIAK 22 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 LDNT(0.572)PAS(0.395)PPRS(0.032)PAEPNDIPIAK;LDNT(0.549)PAS(0.423)PPRS(0.029)PAEPNDIPIAK 60.602 0.02043 125075000.0 288628.0 194385.0 259725.0 278366.0 319215.0 190119.0 201859.0 168076.0 148898.0 117074.0 True False 272587.2112294295 209293.7044537117 243014.57626719802 240452.07059186543 279112.35788169195 216306.16652155094 211245.84347602006 168565.07333352024 178681.76055772716 113693.76942521764 2.397556283053175 1.8408546529137213 2.1374484942821907 2.114909830217419 2.4549485806720375 1.902533160920721 1.8580248024494213 1.4826236669406438 1.5716055634451942 1.0 16.7947936691627 -8.049925888941878 0.7564779314807314 1.0461415902851485 2.1715439415540123 0.795601385705043 0.18911137245620288 0.2730077932261617 0.32059351367865807 0.17904748103859847 0.0757095789415434 8.914030404258542e-09 8.049925888941878 1.1254023512688638 LDNTPAS(ph)PPRS(ph)PAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R2 1 LDNTPASPPRSPAEPNDIPIAK 22 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 2 LDNT(0.014)PAS(0.986)PPRS(1)PAEPNDIPIAK 82.859 0.0016966999999999998 45615000.0 43938.0 34294.0 47918.0 49912.0 51877.0 37915.0 49649.0 51494.0 41593.0 52475.0 True False 41496.10185775001 36924.23952740998 44835.008049173615 43113.89949699752 45359.74747373572 43137.44709189825 51957.776877627126 51643.83901470937 49912.762205520114 50959.91040357625 0.8142891447242008 0.7245742630822742 0.8798093971143873 0.846035622032253 0.8901064996878895 0.8464977028074006 1.0195814016576616 1.013420914709558 0.9794515298444746 1.0 15.637075120636013 -6.724165134072964 0.6484818974843773 1.0189620857936397 0.7807977779685209 0.7607001325492598 0.045852469184532715 0.3741680011643048 0.34623908431075495 0.03588813465798002 0.03992170699533901 1.8872736046892128e-07 6.724165134072964 -0.23816430782511877 LDNTPAS(ph)PPRSPAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R1 2 LDNTPASPPRSPAEPNDIPIAK 22 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 LDNT(0.037)PAS(0.945)PPRS(0.018)PAEPNDIPIAK;LDNT(0.184)PAS(0.739)PPRS(0.077)PAEPNDIPIAK 86.546 0.00031765 87518600.0 8550.8 10410.7 6871.599999999999 8382.2 7969.4 7028.299999999999 7306.3 5134.9 2323.57 7933.5 True False 8750.017003039547 9191.81040419688 5938.474462996948 6918.40612338136 7248.569177111848 6957.601683185821 6755.179908664125 4998.70577149411 3942.928583161711 8951.842003834072 0.9774543607105574 1.0268065946941456 0.6633801691823316 0.7728472107101766 0.8097293466537152 0.7772257017277429 0.7546133975299031 0.5583996868301704 0.44046002839113507 1.0 13.127968858253363 -4.334065991146573 0.5630868949682936 0.6826924505523909 1.457652734121198 0.2883168826800139 0.1527491399029847 7.530344807436524 1.2578425126864876 0.08110707769179959 4.250503179230238 4.633765042200333e-05 4.334065991146573 0.7749602835688071 LDNTPAS(ph)PPRSPAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R2 1 LDNTPASPPRSPAEPNDIPIAK 22 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 LDNT(0.406)PAS(0.473)PPRS(0.121)PAEPNDIPIAK 59.469 0.009404700000000002 72020000.0 73210.0 63451.0 70495.0 78203.0 78676.0 59296.0 62603.0 56255.0 37542.0 39503.0 True False 69141.28128285031 68317.48767287846 65959.42844915272 67551.61649230024 68792.017507636 67463.4857645049 65514.16354549116 56418.69273648339 45051.449011122975 38362.44574887989 1.8023168213895515 1.7808428617946812 1.7193749554166164 1.7608787754173003 1.793212506781964 1.7585814576609655 1.7077681640619604 1.470675073893867 1.1743633163023344 1.0 15.227407080022838 -8.146822371950503 1.4521570065455816 1.002340613179845 1.7712727462758688 0.9932569983593584 0.022423035921889434 0.030555562344240998 0.11775360284950942 0.022434599918616578 0.007119835433753716 7.131446492851841e-09 8.146822371950503 0.7689321330960239 LDNVPHT(ph)PSSYIETLPK ddPTM_A459_Selumetinib_30min_R1 2 LDNVPHTPSSYIETLPK 17 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PNW0;E9PJJ2;E9PKI2;E9PP22 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 LDNVPHT(0.577)PS(0.371)S(0.052)YIETLPK;LDNVPHT(0.977)PS(0.02)S(0.003)YIETLPK 125.04 0.001731 101451000.0 13016.8 18779.4 16948.5 19526.1 16211.7 16424.5 17026.0 14671.0 7586.8 11928.5 True False 13320.066113716275 16580.699117693806 14646.986791446516 16116.233185292247 14745.354597408113 16259.28444225282 15741.71511228875 14281.877421875814 12874.245482051869 13459.63916842941 0.9896302528643922 1.231882884095814 1.0882154126242938 1.1973748317929709 1.0955237664910398 1.2080029961271315 1.1695495633502657 1.0610891750631046 0.9565074754937988 1.0 13.716352113651078 -7.997348770841936 3.6520354328252616 0.9818891675114371 1.1442694324240288 0.47772563672756907 0.06772484892624975 0.18072502819705635 5.1409326333458605 0.0433282431002477 0.01676723169843662 1.0061233522761808e-08 7.997348770841936 0.16238026491259172 LDNVPHT(ph)PSSYIETLPK ddPTM_A459_Selumetinib_30min_R2 3 LDNVPHTPSSYIETLPK 17 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PNW0;E9PJJ2;E9PKI2;E9PP22 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 LDNVPHT(0.99)PS(0.007)S(0.002)Y(0.001)IETLPK;LDNVPHT(0.93)PS(0.05)S(0.016)Y(0.004)IETLPK;LDNVPHT(1)PSSYIETLPK 99.813 0.006286600000000001 27585300.0 284704.4 260099.1 296108.0 332613.0 326012.0 268661.0 247210.1 266213.6 225538.8 324664.0 True False 268881.6692100141 280047.86461957626 277056.73365801433 287310.53561057063 285055.4579757414 305666.61408826313 258705.8594875198 266988.23750196584 270652.86208059883 315290.1067416235 0.8528071876050315 0.8882228101406054 0.8787358934958878 0.9112576940005866 0.9041053045452548 0.969477340241295 0.8205327536633624 0.8468018240761342 0.8584248483965139 1.0 18.266320375892484 LDNVPHTPS(ph)SYIETLPK ddPTM_A459_Selumetinib_30min_R1 1 LDNVPHTPSSYIETLPK 17 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PNW0;E9PJJ2;E9PKI2;E9PP22 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 LDNVPHTPS(0.551)S(0.416)Y(0.03)IET(0.003)LPK 97.457 0.0036934 20456000.0 2128.3 2736.1 2914.5 2982.5 2373.8 2176.4 2485.9 2815.3 1405.3 1718.3 True False 2177.885249049104 2415.7561400216186 2518.7269082025464 2461.6623634588664 2159.0902091284306 2154.5073920130912 2298.386561590427 2740.6290986167946 2384.6914609489518 1938.8605426593663 1.1232810205430703 1.24596694133975 1.2990758503692215 1.2696438497234146 1.1135871619559572 1.11122349679567 1.1854316032642194 1.4135256447365276 1.2299448095828893 1.0 10.92099332242898 -11.736807243513846 2.3390524926488157 0.29123704603984873 1.2239263448698934 0.35292859984241376 0.08983063921308407 3602131.897807122 912100.3630125766 13479884.35849099 0.024777770360550802 1.833127854030191e-12 11.736807243513846 0.9326892988300446 LDNVPHTPS(ph)SYIETLPK ddPTM_A459_Selumetinib_30min_R2 2 LDNVPHTPSSYIETLPK 17 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PNW0;E9PJJ2;E9PKI2;E9PP22 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 LDNVPHT(0.049)PS(0.474)S(0.474)Y(0.001)IETLPK;LDNVPHT(0.003)PS(0.353)S(0.353)Y(0.291)IETLPK 126.43 0.0011696 9429900.0 52230.0 49355.0 68211.0 67575.0 63103.0 49736.0 40682.0 44712.0 39220.0 57151.0 True False 49327.265693256006 53140.36979866215 63822.3785225214 58371.16842662305 55175.436992022354 56586.68254154429 42573.79360985368 44842.104517529944 47065.0958983603 55500.90213386919 0.8887651154620467 0.9574685771861259 1.1499340743791995 1.0517156691585072 0.994135858529618 1.019563292954341 0.7670829116824969 0.8079527141625549 0.848005961864159 1.0 15.760223601345196 -7.246651769790719 24.18296846490161 0.8397564598240189 1.015363741514965 0.44033308612975863 0.0844493545103594 443.84584896140365 725845.7331484477 0.0331305291164647 0.02554023592634196 5.666934985861955e-08 7.246651769790719 0.17560728169094608 LDNVPHTPSS(ph)YIETLPK ddPTM_A459_Selumetinib_30min_R1 1 LDNVPHTPSSYIETLPK 17 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PNW0;E9PJJ2;E9PKI2;E9PP22 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 LDNVPHTPS(0.152)S(0.843)YIET(0.005)LPK 111.49 0.0013372 25187000.0 3543.9 5369.5 4457.8 5524.0 4141.7 4371.5 4165.9 4270.5 2545.0 2967.2 True False 3626.465974771 4740.836443787172 3852.4552449426346 4559.3370983224695 3767.083966276523 4327.526679004423 3851.662809014667 4157.232467461024 4318.679120554385 3348.069022975541 1.0831514971420866 1.415991250853554 1.150649887593664 1.3617810944263133 1.1251512261024383 1.2925440453310624 1.1504132031279228 1.241680634100653 1.2899014598917171 1.0 11.709113555106516 -11.168846461620799 2.6955192137089807 0.9736515798937111 1.237411890153132 0.32088413859562137 0.10230658018724353 25957803.608884826 22887035.550552268 4740781.561981016 0.022653220610268407 6.778811200784023e-12 11.168846461620799 0.2637603102594208 LDNVPHTPSS(ph)YIETLPK ddPTM_A459_Selumetinib_30min_R2 3 LDNVPHTPSSYIETLPK 17 0 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PNW0;E9PJJ2;E9PKI2;E9PP22 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 LDNVPHTPS(0.204)S(0.796)YIETLPK;LDNVPHTPS(0.183)S(0.715)Y(0.097)IET(0.005)LPK;LDNVPHTPS(0.008)S(0.992)YIETLPK 163.95 5.5205e-06 5438300.0 115628.0 110411.0 120367.0 117196.0 120333.0 97456.0 76953.0 91922.0 79433.0 112828.0 True False 109201.8586555581 118879.16867267908 112622.71826568087 101233.70262562332 105215.69274933096 110879.67938251456 80531.46697947675 92189.47780149365 95321.81954345899 109570.36247765005 0.9966368293965705 1.0849573368613052 1.0278574946637913 0.9239150107427342 0.9602568648140838 1.0119495534673584 0.734974907068537 0.841372390460954 0.8699598813767048 1.0 16.7414980930933 -6.482263942819078 0.9645530388279969 0.860574522161778 1.0370926151687136 0.3722750545086302 0.07834642297636246 0.5341977245357846 1.075224421048239 0.04112641371735711 0.05069180543558293 3.294094524711552e-07 6.482263942819078 0.17651809300693566 LDPAQSAS(ph)RENLLEEQGSIALR ddPTM_A459_Selumetinib_30min_R2 2 LDPAQSASRENLLEEQGSIALR 22 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 LDPAQS(0.253)AS(0.747)RENLLEEQGSIALR;LDPAQS(0.287)AS(0.713)RENLLEEQGSIALR 59.574 0.0092851 10083100.0 10444.2 11173.7 13229.5 13286.3 13742.7 9851.4 12422.5 13230.400000000001 11911.8 13284.7 True False 9863.753175445225 12030.686860891732 12378.3283731905 11476.683019854097 12016.219164703203 11208.340927894676 13000.170864716762 13268.898273589371 14294.492843500453 12901.136193204182 0.764564688545887 0.9325292501934078 0.9594758312613522 0.8895869982288512 0.9314078221290991 0.8687871176647833 1.0076764302019188 1.0285061776635545 1.108002630886901 1.0 13.655210507842813 -7.425722745386147 3.217596186711219 1.0488282729265432 0.8977783699986067 0.6176482629192805 0.056102033297773655 0.17863201139357138 3.5156979357374474 0.02647989481337507 0.01632061688111595 3.752124623156639e-08 7.425722745386147 -0.15104990292793652 LDPHLVLDQLR ddPTM_A459_Selumetinib_30min_R1 2 LDPHLVLDQLR 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35579-2;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 ; 110.08 0.012686 18324900.0 18935.7 19438.8 18276.8 20334.0 19922.4 17302.0 17282.8 16117.5 10236.0 13984.9 False True 19376.864967541755 17162.896259147044 15794.910947276145 16783.0486164535 18120.42243758541 17127.957588959074 15979.144481537884 15690.011542981621 17369.74439213938 15779.998139461663 1.227938355650706 1.0876361395903535 1.000945044966589 1.0635646765054725 1.1483158792187025 1.085422028417514 1.0126201752570685 0.9942974266736441 1.100744387840083 1.0 13.945809414800086 -4.7876766154613355 3.7142302683180217 1.0537982962264207 1.2452057628312212 0.5465295125150119 0.048212566239742856 0.20724124895842444 4.98912586874001 0.012834163559068086 0.1085135818127682 1.630509691534167e-05 4.7876766154613355 0.19140746660480046 LDPHNHVLYSNR ddPTM_A459_Selumetinib_30min_R1 2 LDPHNHVLYSNR 12 0 P31948-2;P31948-3;P31948;F5GXD8;F5H783 P31948-2 STIP1 Stress-induced-phosphoprotein 1 0 ; 139.76 0.012971000000000002 24785000.0 6307.1 6708.900000000001 6819.1 7922.2 8373.9 7120.700000000001 7143.7 6299.1 3633.8 5505.2 False True 6454.04315851976 5923.418869117009 5893.103674635098 6538.736488111931 7616.482223532123 7049.072223078302 6604.844957574134 6132.027405639554 6166.293197748733 6211.846045189051 1.0389895550483395 0.953568202757468 0.9486879796705824 1.0526237193492665 1.2261221814135161 1.1347789645459203 1.0632660419344186 0.9871505766612945 0.9926667777808824 1.0 12.600806358979277 -5.88061529805722 5.985688116925272 1.0757042233769358 0.9785328460801473 0.22106377964997936 0.07211635599726156 0.3141773909314894 15.208272983684665 0.022745386307512702 0.03415763746716765 1.3163903862842008e-06 5.88061529805722 -0.09717137729678849 LDPHNHVLYSNR ddPTM_A459_Selumetinib_30min_R2 1 LDPHNHVLYSNR 12 0 P31948-2;P31948-3;P31948;F5GXD8;F5H783 P31948-2 STIP1 Stress-induced-phosphoprotein 1 0 101.56 0.0070069 10029000.0 58304.0 48598.0 63866.0 69956.0 79322.0 53176.0 49985.0 52540.0 47962.0 61346.0 False True 55063.697089404515 52325.31033280079 59756.93109204315 60427.87211916892 69356.86121232272 60500.51131633347 52309.40154339848 52692.88270153476 57555.74017024874 59574.781583950185 0.9242786230245956 0.8783130872089937 1.0030574935106777 1.0143196586296601 1.1641983297007654 1.0155389530229126 0.8780460482206948 0.8844830195018382 0.9661091260425974 1.0 15.862414136693832 -10.437504824431816 15.334680507682036 0.999999999346925 0.971264962192033 0.011452981034659082 0.08315236844013256 0.0 0.0 0.09070203355943156 0.021998474401403185 3.651700706804028e-11 10.437504824431816 -0.028735037154892007 LDPPPS(ph)PHANR ddPTM_A459_Selumetinib_30min_R1 2 LDPPPSPHANR 11 0 E7EUN2;A0A087X1U1;F5GXM9;Q9UPQ3-2;Q9UPQ3;H7C211;H7C0A7 E7EUN2 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 1 LDPPPS(1)PHANR;LDPPPS(1)PHANR 89.74700000000001 0.019051 35069000.0 2757.3 3626.8 4010.2 4047.3 3948.2 3056.6 3606.2 3509.2 2186.5 2936.7 True False 2821.539725228158 3202.1725699464246 3465.636866451828 3340.515032230366 3591.086007111326 3025.8533791707496 3334.181430631722 3416.124616511936 3710.3308043584143 3313.6540508803814 0.8514889248859648 0.9663569343020771 1.0458656254508727 1.0081061513777663 1.083723874602189 0.9131470372916062 1.0061947866120444 1.030923736774613 1.1197097667370082 1.0 11.694207276137682 -4.828824534684015 2.5953722380464868 1.0236185972740055 0.8255386179293265 0.5129892261163564 0.051834654227346164 0.36162560444114566 3.4629686469027723 0.013640871473736962 0.15219456061640418 1.4831171787832038e-05 4.828824534684015 -0.19807997934467902 LDPPPS(ph)PHANR ddPTM_A459_Selumetinib_30min_R2 3 LDPPPSPHANR 11 0 E7EUN2;A0A087X1U1;F5GXM9;Q9UPQ3-2;Q9UPQ3;H7C211;H7C0A7 E7EUN2 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 1 LDPPPS(1)PHANR;LDPPPS(1)PHANR;LDPPPS(1)PHANR 100.11 0.010973 32866700.0 212356.0 221935.0 264313.0 287901.0 257978.0 181674.0 235282.0 229123.0 204943.0 224840.0 True False 200554.10364842165 238956.70086649928 247307.38934223543 248688.38714307302 225568.49728741837 206697.94442762833 246223.07920243836 229789.70999664557 245937.32658586616 218348.28499552322 0.9185055135767776 1.0943832275641578 1.1326280366585244 1.138952784301337 1.0330674101335084 0.9466433154346334 1.1276620707485137 1.0523998848965401 1.1263533697592751 1.0 17.736271674031414 LDPPPS(ph)PHSNR ddPTM_A459_Selumetinib_30min_R1 1 LDPPPSPHSNR 11 0 Q96P47;Q96P47-2;Q96P47-4;H0Y873 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 LDPPPS(0.967)PHS(0.033)NR 83.69200000000002 0.024877 7301200.0 6916.6 9261.0 8736.5 9747.8 9247.4 7470.2 8280.3 7076.1 4010.1 6332.5 True False 7077.7433226392095 8176.717814677906 7550.131286159391 8045.529718868169 8410.97430276107 7395.056570398911 7655.710304492223 6888.418841587857 6804.846813884139 7145.338058773461 0.9905400226583745 1.144343031417255 1.0566513752122477 1.1259830749350481 1.177127552759185 1.0349484530432862 1.0714273056810935 0.9640437981978832 0.9523477766777952 1.0 12.802786554090732 -7.618455992151311 2.0365287737918885 0.965453499040764 1.0959214157530857 0.4849451133068394 0.05297914460401246 0.2669365522958934 2.1969026025214045 0.03300469634193359 0.015574908104782624 2.4073764505193566e-08 7.618455992151311 0.1304679167123216 LDPPPS(ph)PHSNR ddPTM_A459_Selumetinib_30min_R2 2 LDPPPSPHSNR 11 0 Q96P47;Q96P47-2;Q96P47-4;H0Y873 Q96P47 AGAP3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 1 LDPPPS(0.997)PHS(0.003)NR;LDPPPS(0.987)PHS(0.013)NR 84.75299999999999 0.023706 14940000.0 210931.0 209864.0 260222.0 236891.0 247518.0 177131.0 217909.0 207842.0 201689.0 222180.0 True False 199208.2994436948 225959.89398088233 243479.59982829125 204626.0371402314 216422.57600100455 201529.1874148761 228042.2002784918 208446.7858099048 242032.4356615096 215765.0861070336 0.923264755377867 1.0472495715492702 1.1284476289528578 0.9483741824602869 1.003047248773348 0.9340213055364501 1.0569003743514276 0.9660820921995765 1.121740500413703 1.0 17.719101909349284 -8.246839285661453 24.950966506851834 1.0608702687791818 1.004673394862759 0.11460542502387916 0.0659935197321095 1598.8173427263823 2732322.3018460316 0.04434859048857746 0.016630290367334714 5.664488694424238e-09 8.246839285661453 -0.056196873916422696 LDQEDALLGSYPVDDGCR ddPTM_A459_Selumetinib_30min_R1 1 LDQEDALLGSYPVDDGCR 18 0 K7EK42;A0A494C0X0;Q99426;K7EP07;Q99426-2;K7EL99;K7EQH0;K7ER04 K7EK42 TBCB Tubulin-folding cofactor B 0 131.56 0.008489100000000001 0.0 469.28 598.06 437.01 602.64 630.89 609.95 533.69 465.7 249.51 557.92 False True 480.2133109400754 528.0388571694493 377.6664423241016 497.4002369538478 573.8261108926761 603.8144567902888 493.43333362371595 453.3481231932086 423.4002465106189 629.5344666010094 0.7628070207702039 0.838776723410306 0.599913844849835 0.790108029572102 0.9115086485905775 0.9591443976855017 0.7838067013040089 0.7201323315003413 0.672560866757061 1.0 9.29814155649285 -5.995621532272643 24.948978041704006 0.8320981421935861 0.7361076208975518 0.1585307442785705 0.10989126848644727 270.3088440876529 1540218.143638168 0.032719976511678295 0.04831475774161043 1.010132787030804e-06 5.995621532272643 -0.09599052129603436 LDQPGNLPGS(ph)NRR ddPTM_A459_Selumetinib_30min_R2 2 LDQPGNLPGSNRR 13 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 LDQPGNLPGS(1)NRR;LDQPGNLPGS(1)NRR 110.56 0.0028502 41586000.0 193349.0 221550.0 220960.0 203796.0 213880.0 180596.0 169534.0 162363.0 158932.0 230480.0 True False 182603.43661737212 238542.17260446982 206743.67416305764 176038.63323229057 187010.48228853993 205471.4597127379 177417.66692524805 162835.44944935833 190722.84093111177 223825.4435410429 0.8158296649767974 1.0657509210329266 0.9236826291607326 0.786499651010455 0.8355193195640771 0.9179986710271416 0.7926608526644779 0.727510898105287 0.8521052741536906 1.0 17.772014519616363 -5.616343742754874 6.185121188695172 0.8342358039966742 0.9535734476084927 0.16545910140423747 0.09046904098671563 0.2791641835415112 15.156605956875437 0.0238168637729629 0.04169728651925863 2.4191135677941557e-06 5.616343742754874 0.11933764361181853 LDQPVSAPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 LDQPVSAPPSPR 12 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 LDQPVS(0.002)APPS(0.998)PR;LDQPVSAPPS(1)PR;LDQPVSAPPS(1)PR;LDQPVSAPPS(1)PR 150.9 0.00053682 248538000.0 481912.0 532885.0 451381.0 501459.0 484106.0 344325.0 522538.0 455306.0 345674.0 424702.0 True False 455129.26028658566 573755.5660046609 422339.63788647414 433159.4191349743 423288.27631744917 391752.6432788576 546837.0523894037 456630.86508003407 414818.45893854735 412439.74975168344 1.1035048405509027 1.3911257737647753 1.0240032347530788 1.0502368391886705 1.0263033002330577 0.9498421127321484 1.3258592381520853 1.1071456263732016 1.0057674101206202 1.0 18.653823856624122 -5.283289648638269 24.845099860797667 1.068816437030174 1.247315348406264 0.2880057806238322 0.11658885646355434 840.3400248654852 955517.3858366455 0.030657271034453305 0.06390848278916855 5.208472210631148e-06 5.283289648638269 0.17849891137608997 LDQVVES(ph)PAIPR ddPTM_A459_Selumetinib_30min_R2 1 LDQVVESPAIPR 12 0 P16157-14;H0YBS0;P16157-15;P16157-12;P16157-21;P16157;P16157-3;P16157-16;P16157-5;P16157-8;P16157-10;P16157-13;P16157-4;P16157-7;P16157-6;P16157-9;P16157-11;P16157-2 P16157-14 ANK1 Ankyrin-1 1 LDQVVES(1)PAIPR 132.65 0.0018539 3653000.0 25181.0 22924.0 23096.0 28027.0 28765.0 21965.0 22564.0 24107.0 19953.0 22867.0 True False 23781.540827529745 24682.197087722252 21610.028505023467 24209.674250728276 25151.283537637235 24990.479371582365 23613.270709717784 24177.147378871305 23944.15753340088 22206.770294398815 1.0709139830895684 1.1114717160805598 0.9731279343432546 1.0901933928156429 1.1325952943270239 1.1253540717663784 1.0633365589265238 1.0887286651030688 1.0782368266960587 1.0 14.438711965182186 -4.395339105169222 17.190316015408328 1.0777898025373234 0.0004028573929706538 0.0 0.048875798539405504 14453606.85333079 11106459.492951635 0.012250222168165506 608955177.0405957 4.024027081435491e-05 4.395339105169222 -1.0773869451443527 LDRETEELHHDR ddPTM_A459_Selumetinib_30min_R1 3 LDRETEELHHDR 12 1 O60869-2;O60869-3;O60869 O60869-2 EDF1 Endothelial differentiation-related factor 1 0 ;; 101.72 0.0097745 63763000.0 15292.199999999999 15850.4 21005.100000000002 21914.699999999997 20952.5 16246.5 16853.6 15164.9 8754.0 11589.5 False True 15648.4785065586 13994.627799348953 18152.722792755307 18087.709034867385 19057.350074464317 16083.074960641743 15582.319383088789 14762.677589462504 14854.89863313678 13077.12521628978 1.1966298592190403 1.0701608777069953 1.3881279327464884 1.3831563692864295 1.4573042438046822 1.229863191996322 1.1915707103330604 1.1288931890835674 1.1359452775318295 1.0 13.674757803256956 -7.804223712032969 1.1941770424210563 1.0492876770151875 1.293873793694853 0.4279551797629304 0.10665033720059224 0.5380906624730335 1.3877468672350803 0.10341458196433487 0.03947001604008409 1.5695540936472112e-08 7.804223712032969 0.24458611667966546 LDRETEELHHDR ddPTM_A459_Selumetinib_30min_R2 3 LDRETEELHHDR 12 1 O60869-2;O60869-3;O60869 O60869-2 EDF1 Endothelial differentiation-related factor 1 0 ;; 93.623 0.015965 22531200.0 177987.0 187704.0 222538.0 215285.0 286329.0 168084.0 127477.0 142366.0 172479.0 207193.0 False True 168095.19507841373 202100.29323651316 208220.14736105397 185962.81161266053 250357.79120626234 191236.04528536557 133404.9330908834 142780.26149003982 206979.61946591732 201210.79973793542 0.8354183537729948 1.0044207045533156 1.0348358419739287 0.9242188384264938 1.2442562304425897 0.9504263465700581 0.663010798946354 0.7096053575454312 1.0286705273051717 1.0 17.61834821650976 -7.012047470488025 24.751801518578475 0.8233501644925153 1.014380386274843 0.20423970907669686 0.14336151766387298 682.45877323573 1402126.4440741 0.05269327584460669 0.043141305466374395 9.726409036099333e-08 7.012047470488025 0.19103022178232776 LDRS(ph)FLEDTTPAR ddPTM_A459_Selumetinib_30min_R2 1 LDRSFLEDTTPAR 13 1 Q3YEC7;Q3YEC7-2;G3V154;F2Z2T0 Q3YEC7 RABL6 Rab-like protein 6 1 LDRS(1)FLEDTTPAR 84.40299999999998 0.016052 3791900.0 7657.0 6033.9 9267.9 8887.5 13040.0 7338.3 7947.5 7195.9 7177.1 8081.6 True False 7231.454593399599 6496.680727953554 8671.613404126558 7677.00716820735 11401.798620920908 8349.084214545093 8317.074497672487 7216.838877654626 8612.720544929158 7848.2632094815 0.921408265801186 0.8277857857907853 1.1049085858448742 0.9781791159772452 1.4527798465202308 1.0638129725897254 1.0597343992776154 0.9195459791582871 1.097404650563212 1.0 12.938157711112973 -5.266613370480825 24.632022592203317 1.0893981834795154 0.874597020643406 0.2728183939586861 0.13692316561261605 419.8100726128293 1998618.5534311691 0.03692835141368796 0.08081284821317546 5.412359424063936e-06 5.266613370480825 -0.2148011628361094 LDS(ph)LPEHEDSEK ddPTM_A459_Selumetinib_30min_R1 2 LDSLPEHEDSEK 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 LDS(0.999)LPEHEDS(0.001)EK;LDS(1)LPEHEDSEK 149.82 0.00056572 21256000.0 10278.82 12989.6 8197.12 8008.39 8839.6 9990.0 10242.199999999999 10365.16 5419.05 10425.25 True False 10518.296506897943 11468.771593298787 7083.996127557127 6609.875022598607 8040.059740758141 9889.509670194262 9469.622607957466 10090.242286015284 9195.732058247642 11763.432388034438 0.8941519923723091 0.9749511209810348 0.6022048577218709 0.561900200941526 0.683479062534193 0.840699325160716 0.8050050610729742 0.857763444645536 0.7817218440088441 1.0 13.52202145729881 -8.950596073325885 0.6218025345758184 1.0020614707606783 0.7547221128671475 0.23790602651249648 0.12165967377315492 2.52856465143201 1.7893791333556033 0.1652411468803323 0.05695140314124837 1.1204795295891123e-09 8.950596073325885 -0.2473393578935308 LDS(ph)LPEHEDSEK ddPTM_A459_Selumetinib_30min_R2 2 LDSLPEHEDSEK 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 LDS(1)LPEHEDSEK;LDS(1)LPEHEDSEK 149.69 0.00056925 13601300.0 96554.0 79389.0 88623.0 84282.0 86360.0 71356.0 97712.0 97184.0 69460.0 81435.0 True False 91187.91521628635 85477.881024131 82921.09266542653 72802.6462054404 75510.6847318044 81184.64129472483 102255.80161265476 97466.78935032267 83353.9408745566 79083.75995645986 1.1530548783529073 1.0808525172701888 1.048522385772747 0.9205764400367714 0.954819102852183 1.0265652687659468 1.2930063222708736 1.2324501187599541 1.053995673959454 1.0 16.271093843706936 -7.1524775426277545 13.672543983937523 1.1642215327098808 1.0252576328311374 0.2351208661812021 0.09810370384961474 1.2590658681015685 152.63625782004607 0.03886680178613813 0.03010651207509996 7.039186266349772e-08 7.1524775426277545 -0.13896389987874347 LDS(ph)PDPFK ddPTM_A459_Selumetinib_30min_R2 1 LDSPDPFK 8 0 B1AUU8;P42566;P42566-2 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 LDS(1)PDPFK 85.355 0.03539 3809900.0 67668.0 51125.0 50582.0 57536.0 56761.0 48564.0 81216.0 78907.0 58741.0 45309.0 True False 63907.28345646644 55046.12310721516 47327.60918951755 49699.497544863945 49630.17573022171 55253.25017990106 84992.70492645094 79136.606306243 70490.84136067254 44000.811443080245 1.45241147516421 1.2510251811701973 1.0756076453440153 1.129513204754316 1.1279377380215738 1.2557325278279707 1.9316167620317206 1.798526066016184 1.6020350318279921 1.0 15.425242509074687 -7.1240682977763665 7.0411495650447895 1.6481280303194517 1.1977105278857405 0.33311282405607845 0.24854533902282083 0.24312066222343276 12.926561896164504 0.09220710431481183 0.0713710114935556 7.515047020120089e-08 7.1240682977763665 -0.45041750243371115 LDS(ph)PPPS(ph)PITEASEAAEAAEAGNLAVSSR ddPTM_A459_Selumetinib_30min_R1 4 LDSPPPSPITEASEAAEAAEAGNLAVSSR 29 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 2 LDS(0.999)PPPS(0.997)PIT(0.004)EASEAAEAAEAGNLAVSSR;LDS(0.995)PPPS(0.991)PIT(0.014)EASEAAEAAEAGNLAVSSR;LDS(0.739)PPPS(0.927)PIT(0.328)EAS(0.007)EAAEAAEAGNLAVSSR;LDS(0.959)PPPS(0.943)PIT(0.094)EAS(0.004)EAAEAAEAGNLAVSSR 122.68 5.3288e-13 8368300.0 907.2470000000001 1373.6480000000001 1172.9099999999999 1359.73 1048.36 1095.79 1225.69 902.4680000000001 732.356 759.69 True False 928.3840899046434 1212.82065356837 1013.635264333453 1122.2786807932687 953.5360231029904 1084.767347497715 1133.2352164913193 878.5316170107984 1242.7546428340786 857.2036115072427 1.083038005722167 1.4148571439588744 1.1824906600091811 1.3092323290844958 1.112379848034429 1.2654722086277044 1.3220140480961382 1.0248809095263307 1.449777656266417 1.0 9.743494118058683 -10.89686173400071 3.789641458791271 0.9989874718563759 1.2389339875249605 0.22686133672121744 0.13314522784398314 120978501.38042396 66965489.982959546 1162758.399158261 0.03020412290370149 1.268055511455566e-11 10.89686173400071 0.2399465156685846 LDS(ph)PPPSPITEASEAAEAAEAGNLAVSSR ddPTM_A459_Selumetinib_30min_R1 4 LDSPPPSPITEASEAAEAAEAGNLAVSSR 29 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 LDS(0.995)PPPS(0.005)PITEASEAAEAAEAGNLAVSSR;LDS(0.997)PPPS(0.003)PITEASEAAEAAEAGNLAVSSR;LDS(0.728)PPPS(0.264)PIT(0.008)EASEAAEAAEAGNLAVSSR;LDS(0.947)PPPS(0.053)PITEASEAAEAAEAGNLAVSSR 228.96 1.1106e-50 95263000.0 3972.31 4446.0 4922.65 5504.9 4357.719999999999 3991.78 3728.36 3553.97 1898.46 3810.71 True False 4064.8570942302495 3925.4602531106752 4254.181168180909 4543.572554771068 3963.564995417951 3951.626317446251 3447.126803480144 3459.70717067848 3221.5479619676535 4299.851747958724 0.9453481962860616 0.9129292085417167 0.989378568737981 1.0566812116087596 0.9217910820529058 0.9190145495881836 0.8016850360286502 0.8046108036912929 0.7492230315840597 1.0 12.07007120350662 -6.999427041319158 2.2808080529083212 0.8228774219839863 0.9703219044962185 0.3976848178495904 0.07200627826729698 0.2772508569151044 2.8948835295750897 0.030127206753598892 0.02377368878291475 1.0013201567581715e-07 6.999427041319158 0.1474444825122322 LDS(ph)PPPSPITEASEAAEAAEAGNLAVSSR ddPTM_A459_Selumetinib_30min_R2 3 LDSPPPSPITEASEAAEAAEAGNLAVSSR 29 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 LDS(0.824)PPPS(0.171)PIT(0.004)EASEAAEAAEAGNLAVSSR;LDS(0.928)PPPS(0.07)PIT(0.002)EASEAAEAAEAGNLAVSSR;LDS(0.928)PPPS(0.067)PIT(0.005)EASEAAEAAEAGNLAVSSR 120.61 9.0967e-14 11796200.0 29442.4 23801.2 30937.0 32527.1 33894.9 18877.9 25369.5 22446.0 16345.2 21346.199999999997 True False 27806.109275265546 25626.675507079693 28946.547101658773 28096.852867622754 29636.71963774936 21478.159368486 26549.232018710583 22511.31414386467 19614.69672304638 20729.879741911736 1.34135410438716 1.2362192075464673 1.3963683080676321 1.3553794434618185 1.429661918290329 1.0360966699223726 1.2807229153883253 1.0859355878631185 0.946204076784359 1.0 14.339424126664852 -7.548653434387946 0.8732846054926157 0.9696731020149678 1.3408325660216818 0.6587331247839114 0.09885934363058584 0.37563344207079225 0.5297806262242982 0.08482085914348703 0.04080660975071522 2.8271351198096877e-08 7.548653434387946 0.37115946400671396 LDS(ph)PTMSR ddPTM_A459_Selumetinib_30min_R1 1 LDSPTMSR 8 0 P19634 P19634 SLC9A1 Sodium/hydrogen exchanger 1 1 LDS(0.976)PT(0.024)MSR 122.94 0.0061569 4415800.0 3015.6 2588.2 2663.8 2018.2 2790.9 2933.0 2792.6 3094.1 1427.2 2594.7 True False 3085.8576126638513 2285.172340778463 2302.0705912060203 1665.7592563060132 2538.4635877734145 2903.496682950927 2581.9519336648423 3012.034416946761 2421.854161436237 2927.755019518279 1.0540013054683741 0.7805203391486136 0.7862920824518964 0.5689544532247409 0.8670341510305337 0.9917143557416416 0.881887970971583 1.0287863557116705 0.8272051948645346 1.0 11.515579125540725 -6.521497922076566 24.903791192691397 0.9421224973509663 0.7857566040164089 0.24547590742856817 0.12212291525719218 69.97058699535044 1261987.0719647806 0.04021899240187237 0.04075356860109117 3.0095535683352823e-07 6.521497922076566 -0.15636589333455742 LDS(ph)SACLHAVGDK ddPTM_A459_Selumetinib_30min_R1 1 LDSSACLHAVGDK 13 0 E5RJP4;O94808 E5RJP4 GFPT2 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 1 LDS(0.779)S(0.221)ACLHAVGDK 79.317 0.026015 3740500.0 5475.0 6816.7 5216.2 5111.9 4947.4 5760.0 6190.8 5810.3 2456.4 4854.2 True False 5602.556847504508 6018.597595002149 4507.868690535642 4219.202627247399 4499.908543534414 5702.059629661552 5723.822971758328 5656.1919694857215 4168.331391642357 5477.283853912062 1.02287137145594 1.098828864000441 0.8230116990040545 0.7703092882859998 0.8215583971096233 1.0410378176016837 1.0450111997884095 1.0326636559918065 0.7610216126858558 1.0 12.4192449329708 -10.913406377176159 15.960413645677791 0.9999658428630517 0.9376867983311166 0.024198281589306037 0.12259924326062772 8.732033183811695e-11 0.0 0.127904430197944 0.03102138092297438 1.2206569349139912e-11 10.913406377176159 -0.06227904453193511 LDS(ph)SPSVSSTLAAK ddPTM_A459_Selumetinib_30min_R1 2 LDSSPSVSSTLAAK 14 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.848)S(0.151)PS(0.001)VSSTLAAK;LDS(0.792)S(0.208)PSVSSTLAAK 255.39 2.9991e-28 146340000.0 9059.699999999999 12732.4 8211.0 8312.3 8822.5 8107.200000000001 9702.9 9410.5 5573.09 8960.2 True False 9270.773382892517 11241.684688867825 7095.991299794514 6860.712846195851 8024.506432738887 8025.648928748641 8971.002441150395 9160.902970387993 9457.126687611177 10110.328949738965 0.9169606082037396 1.1119009821295744 0.7018556305210745 0.6785845327389655 0.7936939018137554 0.7938069046661288 0.8873106390254507 0.9060934630247135 0.9353925806593412 1.0 13.303542317090738 -8.084116041538607 1.2898188713100327 0.9876691032985917 0.8328796616270786 0.1803252956171405 0.11451084791574714 0.8674258281124476 2.636629347516651 0.1171239090546245 0.038887272930457774 8.239179384197202e-09 8.084116041538607 -0.1547894416715131 LDS(ph)SPSVSSTLAAK ddPTM_A459_Selumetinib_30min_R2 1 LDSSPSVSSTLAAK 14 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.779)S(0.22)PSVSSTLAAK 230.69 2.4106e-13 34500000.0 65076.0 50638.0 66170.0 64067.0 65924.0 61736.0 59485.0 60816.0 51594.0 54248.0 True False 61459.33643986837 54521.77177316694 61912.69424044874 55340.96407826055 57642.03775196239 70239.57361639016 62251.17036729135 60992.9644913692 61914.24165680778 52681.71928676901 1.1666159964392782 1.0349277227719493 1.1752215963839678 1.0504775627578922 1.0941563512419223 1.3332817259445593 1.1816465219829244 1.15776336302463 1.1752509693121864 1.0 15.685014808781322 LDS(ph)SPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPK ddPTM_A459_Selumetinib_30min_R1 1 LDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPK 35 3 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.178)S(0.164)PS(0.164)VS(0.164)S(0.164)T(0.164)LAAKDDPDGKQEAKPQQAAGMLSPK 56.041 0.00043441 31581000.0 2266.5 1590.2 4587.9 5046.7 2722.1 2211.6 2071.7 1799.1 1585.3 1589.0 True False 2319.3050401587157 1404.018644736077 3964.888379530781 4165.388583291822 2475.8865356257884 2189.3533119721337 1915.430001064761 1751.3820236995964 2690.1383142691043 1792.9636281707124 1.2935594474523768 0.7830714592735716 2.2113601844650885 2.323186325615316 1.3808905527837363 1.2210807166266064 1.068303880218137 0.9768084506468545 1.5003864395251245 1.0 10.808130506839388 -6.51682711501836 17.52020348513854 1.1637061704704077 1.6582518249249554 0.23187099391379606 0.42830893762633526 9.345096300560249 27059.10299471227 0.15232407516711635 0.15883896152122393 3.042095789405113e-07 6.51682711501836 0.4945456544545477 LDS(ph)SPVSSPR ddPTM_A459_Selumetinib_30min_R1 1 LDSSPVSSPR 10 0 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 LDS(0.5)S(0.5)PVSSPR 99.752 0.018158 22611000.0 3053.6 4057.2 3971.1 4323.6 5038.4 3589.7 4371.9 2928.6 1684.8 2534.2 True False 3124.7429387287216 3582.181137858893 3431.8464316909017 3568.56442402372 4582.67760960177 3553.5908771868185 4042.124063163117 2850.9240145665262 2858.982547076634 2859.4892551983758 1.0927626089337916 1.2527346033375393 1.2001606319911906 1.247972664186896 1.6026210279583124 1.2427362231652415 1.4135825325500992 0.9970046256980059 0.9998227976829007 1.0 11.481541769150256 -7.7757454107390025 24.86986829193627 0.9988100829407768 1.296305224117 0.5236642380229831 0.12859491850679017 189.91784138210383 330151.54219518625 0.07267940950740027 0.035175245344786284 1.6759250378970387e-08 7.7757454107390025 0.29749514117622333 LDSDAGFHS(ph)LPR ddPTM_A459_Selumetinib_30min_R2 3 LDSDAGFHSLPR 12 0 Q5SYE7-2;Q5SYE7 Q5SYE7-2 NHSL1 NHS-like protein 1 1 LDS(0.001)DAGFHS(0.999)LPR;LDSDAGFHS(1)LPR;LDSDAGFHS(1)LPR 111.81 0.004393800000000001 14377000.0 150699.0 105107.0 146535.0 147371.0 146154.0 109743.0 106287.0 111256.0 79750.0 110368.0 True False 142323.75287589463 113168.36892772742 137107.09763524472 127298.81557084499 127792.82788666221 124859.10210223362 111229.55610369502 111579.73654057764 95702.22840117903 107181.38906949763 1.3278774805167928 1.0558583902504546 1.2792062019866426 1.1876951462935696 1.1923042703225268 1.1649326733512808 1.0377693092927964 1.041036485058316 0.892899683723306 1.0 16.709694893029983 -7.4187423266370915 1.3096550328012442 0.957669460624145 1.2065747026287859 0.6746618887549912 0.0729184967085712 0.26155688494204243 0.8577518543702026 0.04720130752808689 0.023892233376678444 3.812919824885856e-08 7.4187423266370915 0.24890524200464081 LDSPT(ph)MSR ddPTM_A459_Selumetinib_30min_R2 2 LDSPTMSR 8 0 P19634 P19634 SLC9A1 Sodium/hydrogen exchanger 1 1 LDS(0.214)PT(0.786)MSR;LDS(0.471)PT(0.529)MSR 131.62 0.008238500000000001 12349200.0 135913.0 44200.0 84045.0 98782.0 71870.0 57121.0 177722.0 108532.0 81888.0 64384.0 True False 128359.49956284708 47589.997874599714 78637.63620127707 85327.72119154535 62841.04807404792 64988.89925718903 185986.4251494623 108847.8101515602 98267.88814189007 62525.06663027824 2.052928632957074 0.7611347006794534 1.257697759304685 1.3646962057010388 1.0050536762421722 1.0394055178138373 2.974589795309342 1.7408667598100538 1.5716558724033904 1.0 15.93214706937466 LDSQEPGRQT(ph)PDR ddPTM_A459_Selumetinib_30min_R1 1 LDSQEPGRQTPDR 13 1 Q8TB03-2;Q8TB03 Q8TB03-2 CXorf38 Uncharacterized protein CXorf38 1 LDSQEPGRQT(1)PDR 118.16 0.036023 53605000.0 4623.7 5105.8 5088.1 5470.9 4626.7 4378.6 4468.0 4719.5 2358.5 3246.8 True False 4731.423213845948 4508.010562377975 4397.16396693271 4515.510016512019 4208.215801910227 4334.55525945071 4130.975162792562 4594.323528903477 4002.202241975451 3663.558406510173 1.2914829487741128 1.2305005304043204 1.2002439920485268 1.2325475713688423 1.148668953777888 1.1831544030383603 1.1275854522891693 1.2540604022415276 1.092435768149214 1.0 11.839029900779153 -14.5228787446353 0.07920310083141094 0.344906316251728 1.3955799013245644 0.7154512583388785 0.04375647873393526 142.2657439036409 0.7959592349004203 16.280056658221305 1.5459678499979161 3.0000000044557643e-15 14.5228787446353 1.0506735850728364 LDSQPQET(ph)SPELPR ddPTM_A459_Selumetinib_30min_R2 1 LDSQPQETSPELPR 14 0 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 LDS(0.006)QPQET(0.497)S(0.497)PELPR 93.716 0.032934 5394100.0 28567.0 27028.0 29214.0 35227.0 32508.0 25117.0 27023.0 22886.0 22378.0 31590.0 True False 26979.360502761698 29100.960691282366 27334.40304579821 30429.02183003548 28424.054414792678 28576.638760575224 28279.62304505866 22952.594471018758 26854.22529356211 30677.91461932296 0.8794391938808099 0.9485964431543426 0.8910124232688624 0.9918869065131725 0.9265315054006098 0.9315052576153852 0.9218235136245636 0.7481797493680261 0.8753601940285589 1.0 14.904912796203368 -7.559766426175564 24.998620883719084 0.8540622454312612 0.9299280901809999 0.10043223373996579 0.06420865841088637 246.28986193793145 166906.98119296334 0.028264234011261286 0.016318410458971495 2.7557103909594354e-08 7.559766426175564 0.07586584474973868 LDSQPQETS(ph)PELPR ddPTM_A459_Selumetinib_30min_R1 4 LDSQPQETSPELPR 14 0 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 LDSQPQET(0.233)S(0.767)PELPR;LDS(0.001)QPQET(0.229)S(0.77)PELPR;LDS(0.001)QPQET(0.213)S(0.786)PELPR;LDSQPQET(0.029)S(0.971)PELPR 202.32 4.8431e-05 727430000.0 15102.3 17348.9 17980.2 19173.4 17587.7 15037.5 15783.7 15113.0 9165.5 12640.4 True False 15454.154206039688 15317.682722715213 15538.58759816895 15825.125619293274 15996.89564036063 14886.236402957575 14593.12280147022 14712.154146057477 15553.1840783659 14262.918467922625 1.083519774777943 1.0739515027842834 1.089439558468718 1.10952927725725 1.1215723960238382 1.043701991036182 1.0231512459592491 1.0314967570729079 1.0904629451079797 1.0 13.799981594739318 -6.844201568183827 7.57473442089204 1.0383430641182092 1.094736214010715 0.5823735563770827 0.02450276640866649 0.18433721086980534 14.474112462046202 0.00880288613119828 0.007774362827110133 1.43152333515148e-07 6.844201568183827 0.05639314989250588 LDSQPQETS(ph)PELPR ddPTM_A459_Selumetinib_30min_R2 6 LDSQPQETSPELPR 14 0 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 LDSQPQET(0.422)S(0.578)PELPR;LDSQPQET(0.08)S(0.92)PELPR;LDSQPQET(0.079)S(0.921)PELPR;LDS(0.001)QPQET(0.239)S(0.76)PELPR;LDSQPQET(0.084)S(0.916)PELPR;LDSQPQET(0.07)S(0.93)PELPR 202.32 4.8431e-05 727346000.0 274522.0 276970.0 305051.0 300016.0 316550.0 233675.4 238979.7 242726.7 217110.6 275773.0 True False 259265.16623863747 298212.70840108336 285424.35077441554 259153.3032435323 276782.1590070945 265862.0652559187 250092.72957929198 243432.99451143184 260538.78657701545 267810.7169456969 0.9680910801310756 1.113520443849717 1.065768965594794 0.9676733858864952 1.0334991898894648 0.9927237725509942 0.9338413803283401 0.9089740593196348 0.9728467536638723 1.0 18.03085416838899 -6.707308117625739 1.168359627331438 0.9469618256220945 1.0437604332796624 0.3475363778502665 0.046867266362867345 0.46841122476393776 1.35546508464064 0.023720597918992448 0.022541919795794643 1.961967831414074e-07 6.707308117625739 0.09679860765756787 LDSS(ph)ACLHAVGDK ddPTM_A459_Selumetinib_30min_R2 1 LDSSACLHAVGDK 13 0 E5RJP4;O94808 E5RJP4 GFPT2 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 1 LDS(0.093)S(0.907)ACLHAVGDK 77.324 0.02867 6296800.0 44437.0 44868.0 49367.0 56195.0 60988.0 61650.0 39943.0 46529.0 35343.0 64010.0 True False 41967.36943540525 48309.23132664118 46190.780966725535 48541.14405821797 53326.14220036228 70141.72789702045 41800.42864555295 46664.39168670939 42412.58756592931 62161.86498204695 0.6751304750513181 0.7771522193002645 0.7430726375417783 0.7808830071658436 0.857859432238133 1.128372321475203 0.6724448929842338 0.7506916290266804 0.6822927140004332 1.0 15.92374216772217 -6.010784788246207 3.3827538677798192 0.8406056096586344 0.7372000622094641 0.13529983409128354 0.13248678019941199 0.605858893656409 14.558070218408883 0.04187871331466468 0.060651509295774675 9.754729071047266e-07 6.010784788246207 -0.1034055474491703 LDSS(ph)IISEGK ddPTM_A459_Selumetinib_30min_R2 1 LDSSIISEGK 10 0 G5EA36;P30260;P30260-2;I3L328 G5EA36 CDC27 Cell division cycle protein 27 homolog 1 LDS(0.186)S(0.813)IISEGK 128.08 0.0031781999999999995 4213700.0 27503.0 24691.0 27896.0 32135.0 27623.0 27116.0 27489.0 33976.0 26611.0 27655.0 True False 25974.493363232217 26584.720305921735 26101.2017308683 27758.157564032983 24152.751787246783 30850.982865459926 28767.292968420134 34074.86453497042 31933.943573464203 26856.528293680818 0.9671575223423 0.9898792582277645 0.971875495054577 1.0335720708385199 0.8993251667949123 1.1487330949145418 1.0711471212453363 1.2687739890411684 1.1890570227194284 1.0 14.71298520117242 -6.77822039334496 24.991204819560217 1.148315987323674 0.9767086396313912 0.5504088618417453 0.0732342225723274 176.26063436399804 262495.2277420574 0.025295665220202865 0.022367443388506925 1.666401341868061e-07 6.77822039334496 -0.1716073476922827 LDSS(ph)PSVSSTLAAK ddPTM_A459_Selumetinib_30min_R1 3 LDSSPSVSSTLAAK 14 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.001)S(0.991)PS(0.007)VSSTLAAK;LDS(0.226)S(0.774)PSVSSTLAAK;LDS(0.204)S(0.795)PSVSSTLAAK 244.23 5.3012e-20 687130000.0 20013.4 25348.3 18539.6 19108.4 21039.1 18834.0 21700.7 20365.1 11315.6 19615.4 True False 20479.673280702584 22380.50925189503 16022.024150733201 15771.476649092157 19136.117119754785 18644.547059903776 20063.7987276662 19824.95139283232 19201.746741275132 22133.22766017607 0.9252908611043341 1.0111724144130994 0.7238900894495993 0.7125701181608275 0.8645877326869079 0.8423781359937206 0.9065012584570591 0.8957099116864464 0.8675529405873549 1.0 14.4339262323958 -7.2705868343299915 5.794652869649669 0.9091541733410291 0.8431201088340707 0.13188180100107993 0.08768355632959723 0.433374885693565 59.0693381318063 0.03948470701973235 0.027866612620533377 5.363066297303986e-08 7.2705868343299915 -0.06603406450695837 LDSS(ph)PSVSSTLAAK ddPTM_A459_Selumetinib_30min_R2 5 LDSSPSVSSTLAAK 14 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.235)S(0.74)PS(0.016)VS(0.005)S(0.002)T(0.001)LAAK;LDS(0.023)S(0.973)PS(0.004)VSSTLAAK;LDS(0.32)S(0.679)PS(0.001)VSSTLAAK;LDS(0.074)S(0.921)PS(0.004)VSSTLAAK;LDS(0.226)S(0.773)PS(0.001)VSSTLAAK 241.41 1.2543e-19 975779000.0 655849.0 525848.0 640296.0 660998.0 674972.0 511964.0 602085.0 610591.0 519343.0 587406.0 True False 619399.5381515643 566178.850732182 599100.0524615742 570968.9321148483 590175.983033759 582482.3938535304 630083.1455087946 612367.7187212178 623226.1116558432 570446.062515925 1.085816133815934 0.9925195175071896 1.0502308488540917 1.0009165977877332 1.0345868291750777 1.021099858739527 1.1045446483228283 1.0734892550934603 1.0925241711847993 1.0 19.121730956008577 -7.2415398961768815 24.75272652106102 1.0737636255409424 1.0288074134694103 0.19550136317440492 0.03554863290579089 918.7329858591032 1142803.333946678 0.012576593692897788 0.009723108177718808 5.7340318881966874e-08 7.2415398961768815 -0.04495621207153211 LDSS(ph)PSVSSTLAAKDDPDGK ddPTM_A459_Selumetinib_30min_R1 2 LDSSPSVSSTLAAKDDPDGK 20 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.113)S(0.372)PS(0.095)VS(0.309)S(0.08)T(0.031)LAAKDDPDGK;LDS(0.096)S(0.387)PS(0.387)VS(0.092)S(0.028)T(0.009)LAAKDDPDGK 106.31 0.00026139 47280000.0 7692.4 8218.8 9419.8 9645.8 7391.5 7555.400000000001 7546.3 7627.3 4830.8 6569.2 True False 7871.617953195184 7256.539075183542 8140.642899257623 7961.342104091042 6722.940130075314 7479.399535754326 6977.076515439018 7424.9992270379225 8197.51477232775 7412.420809426708 1.0619496862866304 0.9789701990414624 1.0982434900221534 1.0740542541737843 0.906983063013024 1.0090360123972506 0.9412682704907899 1.0016969378742258 1.1059160000606822 1.0 12.855729071375345 -4.732167635895142 23.355855543852584 1.0118683427957336 1.061950319911395 0.05435126594872941 0.06123122930380681 5130.415501592992 4093041.2199984514 0.015708604259386173 1.457029160548128 1.8528163058468867e-05 4.732167635895142 0.050081977115661536 LDSS(ph)PSVSSTLAAKDDPDGK ddPTM_A459_Selumetinib_30min_R2 3 LDSSPSVSSTLAAKDDPDGK 20 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.175)S(0.553)PS(0.143)VS(0.057)S(0.057)T(0.016)LAAKDDPDGK;LDS(0.111)S(0.424)PS(0.424)VS(0.022)S(0.016)T(0.002)LAAKDDPDGK;LDS(0.191)S(0.593)PS(0.159)VS(0.022)S(0.022)T(0.014)LAAKDDPDGK 63.43600000000001 0.011144 50140500.0 283925.0 332263.0 336063.0 329143.0 324083.0 265790.0 182729.0 193391.0 139821.0 305873.0 True False 268145.58514182875 357746.5037060653 314441.07245772827 284313.1555966549 283368.7962012203 302400.15989860607 191226.26057064417 193953.73579239642 167789.10692515605 297041.651736504 0.9027204891107056 1.2043647805440114 1.0585756934069932 0.9571491201134981 0.9539699047074636 1.018039585124767 0.6437691800215102 0.6529513105604681 0.5648672701092987 1.0 18.18030571704697 -7.256566411862318 24.411829644523394 0.686476206648248 1.0208417550938742 0.5510197397460569 0.13176773199064096 199.83118817940266 1001086.7150449912 0.04993850820914697 0.03739366092654104 5.539028352141616e-08 7.256566411862318 0.33436554844562616 LDSSEMDHS(ph)ENEDYTMSSPLPGK ddPTM_A459_Selumetinib_30min_R2 4 LDSSEMDHSENEDYTMSSPLPGK 23 0 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 LDS(0.003)S(0.003)EMDHS(0.994)ENEDYTMSSPLPGK;LDSSEMDHS(0.994)ENEDY(0.004)T(0.002)MSSPLPGK;LDS(0.002)S(0.002)EMDHS(0.995)ENEDYTMSSPLPGK;LDS(0.005)S(0.005)EMDHS(0.991)ENEDYTMSSPLPGK 103.12 2.0493e-05 30192400.0 176424.0 126913.0 180705.0 187935.0 207419.0 157535.0 155359.0 186885.0 165478.0 163398.0 True False 166619.06036122888 136646.81901038604 169078.63703672754 162337.928794042 181361.17087061284 179234.01628965308 162583.5013380184 187428.80440952283 198578.223841633 158680.2751810107 1.0500300694031581 0.8611455888547552 1.0655302736515624 1.0230504617467984 1.142934562369075 1.1295292756783804 1.0245980551303884 1.1811726706152856 1.2514360944680094 1.0 17.275763278935436 -5.853358808433396 1.462038858982773 1.1268629543552593 0.9608802635878271 0.3371187295499408 0.08432102010944043 0.4400274288339027 1.9096163978420053 0.028114479727366245 0.058324250882048075 1.4016551968238848e-06 5.853358808433396 -0.16598269076743222 LDSSPS(ph)VSSTLAAKDDPDGK ddPTM_A459_Selumetinib_30min_R2 1 LDSSPSVSSTLAAKDDPDGK 20 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LDS(0.052)S(0.174)PS(0.611)VS(0.055)S(0.055)T(0.055)LAAKDDPDGK 51.971 0.03424 4523300.0 37365.0 42081.0 38305.0 39470.0 34902.0 25541.0 22352.0 17620.0 13578.0 41507.0 True False 35288.40288394622 45308.47738825858 35840.49800333059 34094.11791045222 30517.298732161144 29059.04091188641 23391.412289647757 17671.271282851973 16293.979401018256 40308.58506186259 0.8754562540408756 1.1240403829289103 0.8891529670000891 0.8458277029106115 0.7570917878989174 0.7209144371425783 0.5803084443115126 0.4383996921680935 0.40423099386920874 1.0 15.298799521208759 -6.416858849114593 1.0095153467563585 0.565226416439213 0.9906012592546078 0.43470906918298735 0.16663468522005612 0.43437939619003363 0.946425884267442 0.07892936155141503 0.10319668988857603 3.8294918614503886e-07 6.416858849114593 0.42537484281539484 LDT(ph)PDINIVLK ddPTM_A459_Selumetinib_30min_R1 1 LDTPDINIVLK 11 0 P30414;A0A087WYW3 P30414 NKTR NK-tumor recognition protein;Putative peptidyl-prolyl cis-trans isomerase 1 LDT(1)PDINIVLK 122.45 0.0097028 11691000.0 2574.8 2996.2 3249.3 3169.5 2151.1 2498.3 2428.4 2202.4 1896.6 2229.7 True False 2634.787830311342 2645.4035111044104 2808.0629071273065 2616.0063238836124 1956.5333848075506 2473.1693702749085 2245.2238328839444 2143.9851975965703 3218.391677816679 2515.9037141172016 1.047253046898043 1.051472477368892 1.1161249500013635 1.0397879335384406 0.777666241290984 0.9830143166439547 0.8924124640722846 0.8521729927764216 1.279218938212018 1.0 11.296860994707702 -6.018599992757707 24.69295534483534 0.9499322165763244 1.0709947591881817 0.12910225295644873 0.12552028913583255 1147.4977953258538 1523395.1928368425 0.036073983597901996 0.04744920355979613 9.580761017118924e-07 6.018599992757707 0.12106254261185723 LDTDDLDEIEK ddPTM_A459_Selumetinib_30min_R2 2 LDTDDLDEIEK 11 0 I3L352;I3L0H8;F6QDS0;H3BQK0;Q9UMR2-3;Q9NUU7-2;Q9UMR2-2;Q9UMR2-4;Q9NUU7;Q9UMR2 I3L352 DDX19A;DDX19B ATP-dependent RNA helicase DDX19B;ATP-dependent RNA helicase DDX19A 0 ; 165.11 0.0083751 5509100.0 45951.0 44998.0 40477.0 46648.0 43466.0 34604.0 36628.0 35620.0 24998.0 37337.0 False True 43397.227376427465 48449.20190862528 37872.75388802539 40294.46192771158 38005.41248902977 39370.38689616375 38331.27457700509 35723.64830279157 29998.29850247859 36258.98379682372 1.1968682746213382 1.3361985592345647 1.0445067655575897 1.111295952294211 1.0481654064546353 1.0858105433063072 1.0571524781773642 0.9852357833018187 0.8273342317196003 1.0 15.146050871872916 -5.260919609784341 0.3635289259303031 0.9364325199310437 1.429835183005242 0.6171700623695782 0.07854989082550995 2.9742153585215396 0.40775067380287017 0.07656680148828199 0.624487174547837 5.483784632932715e-06 5.260919609784341 0.49340266307419833 LDTGPQSLS(ph)GK ddPTM_A459_Selumetinib_30min_R1 1 LDTGPQSLSGK 11 0 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 LDTGPQS(0.01)LS(0.99)GK 113.54 0.0070392 15006000.0 2175.6 2399.2 2184.6 2307.6 2134.6 1537.2 2410.8 2580.5 1226.5 1934.3 True False 2226.2872470193233 2118.3005486421807 1887.9433191488354 1904.620979016823 1941.5258068942387 1521.737163665928 2228.951415053785 2512.0567573546814 2081.280919984264 2182.586246677537 1.0200225766144686 0.9705460903855617 0.865002847893308 0.8726440853900508 0.8895528457808919 0.6972174254201441 1.0212432239261233 1.1509541770359288 0.9535847314865628 1.0 11.091822948915663 -7.495052748497462 24.966582320728843 1.0485814473285089 0.8858818260569689 0.3774036140949151 0.09123891133071867 701.648444435575 629548.6041430698 0.03922319588014051 0.026368911570202623 3.1985066021906045e-08 7.495052748497462 -0.16269962127154003 LDTGPQSLS(ph)GK ddPTM_A459_Selumetinib_30min_R2 4 LDTGPQSLSGK 11 0 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 LDTGPQS(0.177)LS(0.823)GK;LDT(0.07)GPQS(0.13)LS(0.8)GK;LDTGPQS(0.01)LS(0.99)GK;LDTGPQS(0.011)LS(0.988)GK 123.95 0.0037151 76846000.0 261531.0 189488.0 210765.0 251974.0 230617.0 188649.0 199753.0 241238.0 174217.0 155316.0 True False 246996.154011544 204021.1203000487 197204.6093635808 217654.70652060563 201644.83071786174 214633.68736488267 209041.9103030606 241939.96264089935 209065.26802969503 150831.6235205689 1.6375621255436608 1.3526415451745526 1.3074486951782232 1.4430309867408149 1.3368869605143743 1.423001903414592 1.3859289280576734 1.6040400348001693 1.386083787669267 1.0 17.20257941175209 -8.565419036645626 22.55667936408519 0.9999999982990941 1.428458946434018 0.6155525212562754 0.10265523469067948 5357.561177523217 2840801.7657813206 0.09842074633349385 0.02541212733451206 2.7200755289501863e-09 8.565419036645626 0.4284589481349239 LDTGS(ph)PEPETR ddPTM_A459_Selumetinib_30min_R1 2 LDTGSPEPETR 11 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 LDT(0.05)GS(0.948)PEPET(0.002)R;LDT(0.138)GS(0.817)PEPET(0.045)R 145.14 0.00070712 81875000.0 7588.4 8320.6 7270.7 8472.3 6952.0 7078.2 7615.200000000001 7057.0 3995.5 6211.3 True False 7765.1949555439605 7346.4202838579995 6283.378875096328 6992.771849767831 6323.19282747529 7006.999734491395 7040.779332967306 6869.825435633402 6780.071680225955 7008.580858185491 1.1079553924921621 1.048203685240777 0.8965265582629068 0.9977443353030312 0.9022073020803177 0.9997744017332341 1.0045941504326386 0.9802020658162154 0.9673957991520274 1.0 12.774906632446024 -5.033131206444804 5.8262684774667415 0.9688114771518701 1.0954507474416422 0.5969977055209359 0.037459665284995294 0.10212047608728729 10.650527799629012 0.009344386694289724 0.02829205435879486 9.265498574034141e-06 5.033131206444804 0.12663927028977207 LDTGS(ph)PEPETR ddPTM_A459_Selumetinib_30min_R2 2 LDTGSPEPETR 11 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 LDT(0.008)GS(0.992)PEPETR;LDT(0.001)GS(0.999)PEPETR 166.24 0.0006064 134294000.0 188169.0 162573.0 184211.0 225968.0 233950.0 158896.0 173806.0 167461.0 185644.0 163491.0 True False 177711.32028018913 175041.8263454141 172359.06481377163 195190.76858345733 204559.10946046334 180782.48168572507 181888.32339005513 167948.28378533904 222777.98732675123 158770.5900293681 1.119296213784414 1.1024826846901323 1.0855855910209193 1.2293886956479316 1.2883942134536734 1.1386396035455018 1.1456046321702962 1.0578047468002312 1.4031439152902536 1.0 17.276584173137586 -5.748821138255837 24.951433715861437 1.1841404443828307 1.1024575949408806 0.09934103195494737 0.10717776566672735 515.0864653438891 1018528.4979812341 0.028125146243585846 0.048289777563442195 1.7831129813174124e-06 5.748821138255837 -0.08168284944195014 LDVGNFSWGSECCTR ddPTM_A459_Selumetinib_30min_R1 1 LDVGNFSWGSECCTR 15 0 P62241 P62241 RPS8 40S ribosomal protein S8 0 164.92 0.0012533 7792100.0 456.28 459.73 476.15 644.95 411.3 518.41 431.68 555.45 494.83 419.6 False True 466.9104362336724 405.90459787732163 411.4914453047321 532.3215897109122 374.0979876209131 513.195266078619 399.1180300524382 540.7176616441226 839.6903690467301 473.4597472501134 0.9861671217997309 0.8573159603004126 0.8691160076325444 1.124322802102338 0.7901368380178035 1.0839258649954768 0.8429819691548078 1.1420562461426715 1.7735200804792999 1.0 8.887097965180773 -8.010447052536913 12.041530604364398 1.4105290676758644 0.9417981630301367 0.44720429269546647 0.20024159726721882 0.4601650442470783 521.1104049629761 0.10994770859110962 0.04707608274343829 9.762317934890065e-09 8.010447052536913 -0.46873090464572764 LDVTILS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 3 LDVTILSPSR 10 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 LDVTILS(0.826)PS(0.174)R;LDVTILS(0.977)PS(0.023)R;LDVTILS(0.861)PS(0.139)R 187.58 0.00018696 76877300.0 10389.2 10410.8 11912.900000000001 12542.5 10045.7 8917.1 9568.2 9180.099999999999 6024.8 7696.6 True False 10631.248146135851 9191.89869615039 10295.193612875662 10352.187826884438 9137.068208712386 8827.402070079006 8846.46297059799 8936.613926832668 10223.6455660181 8684.533581232667 1.224158792950038 1.0584216884156155 1.1854630437636446 1.192025769726492 1.0521081095774274 1.0164509109798456 1.0186457209072521 1.0290263539477524 1.1772244842384472 1.0 13.084232653101273 -6.27495187900741 22.81751568817308 1.047224457823816 1.1588637520070884 0.46248164384666424 0.06116226492297422 231.7718132843894 391373.7039378125 0.018783371053625094 0.021450218132399626 5.309432709093014e-07 6.27495187900741 0.11163929418327245 LDVTILS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 3 LDVTILSPSR 10 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 LDVTILS(0.588)PS(0.412)R;LDVTILS(0.993)PS(0.007)R;LDVTILS(0.767)PS(0.233)R 179.6 0.00011142 34919400.0 40134.0 39900.0 39365.0 48179.0 45480.0 31535.7 34012.2 32410.0 27591.5 38751.0 True False 37903.51294913143 42960.2017012789 36832.29875737133 41616.937086589256 39766.3958036413 35879.45642241795 35593.83469389572 32504.307734235666 33110.57097092321 37632.15794281054 1.007210721392413 1.1415822012270826 0.9787453276887615 1.105887606813151 1.0567131405027093 0.9534254314340367 0.9458356001797066 0.8637375455224319 0.8798477892562322 1.0 15.199678399864833 -6.8996748525390315 2.352977309385573 0.9111302082034916 1.0624386879858243 0.5780390256814697 0.05536193849976735 0.19557004928198762 2.202987502802205 0.021489138839845337 0.018185650976511966 1.2598682966048905e-07 6.8996748525390315 0.15130847978233275 LDVTILSPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LDVTILSPSR 10 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 LDVTILS(0.452)PS(0.548)R 132.86 0.0023684 10328000.0 2018.8 2542.7 2183.5 2347.2 2393.6 1895.2 2202.9 1843.4 1030.4 1766.6 True False 2065.8341120990126 2244.9995019308394 1886.992693106969 1937.3055824008882 2177.0993026244023 1876.13600870392 2036.7334794350359 1794.5070437929153 1748.5135425615867 1993.360318141207 1.0363575984222395 1.126238684245648 0.9466390375757932 0.9718792757986727 1.092175500239982 0.9411926141147438 1.0217588164563616 0.9002421827410908 0.8771688322721615 1.0 10.960986798758118 -7.410350920067279 1.4217510080013216 0.9207718800070339 1.0281709221957198 0.2843182600294334 0.0642152992790578 0.5327584528093998 2.073017073514531 0.042658610417008844 0.022078258318599688 3.8873091441616025e-08 7.410350920067279 0.1073990421886859 LDVTILSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 LDVTILSPSR 10 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 LDVTILS(0.102)PS(0.898)R;LDVTILS(0.328)PS(0.672)R 103.14 0.014545 20652100.0 17304.4 19925.5 20726.2 23611.3 23959.6 18693.2 20923.9 17846.2 15036.6 18319.7 True False 16342.690723001702 21453.72177941937 19392.698856980318 20395.40020823564 20949.580846458306 21268.01862002565 21896.90280992129 17898.12948740254 18044.340157707393 17790.762660703098 0.9186054040898454 1.205891067661037 1.0900431435587434 1.1464039286683174 1.1775538376852457 1.195452888987342 1.230801805831966 1.0060349760573557 1.0142533235837272 1.0 14.118840737441209 -7.788363118535645 24.503071802242427 1.0076078967003839 1.142676957837987 0.34270760893089647 0.08298222952381429 201.85916905985601 183706.85264469948 0.04449744201733953 0.021385703677668656 1.6279343291187243e-08 7.788363118535645 0.13506906113760309 LDY(ph)RIS(ph)YMLSIY(ph)K ddPTM_A459_Selumetinib_30min_R1 3 LDYRISYMLSIYK 13 1 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 3 LDY(0.962)RIS(0.997)Y(0.039)MLS(0.027)IY(0.975)K;LDY(0.942)RIS(1)Y(0.058)MLSIY(1)K;LDY(0.95)RIS(0.948)Y(0.046)MLS(0.057)IY(0.999)K 89.663 0.007166800000000002 20415400.0 2066.35 2511.25 1734.09 2692.3199999999997 2627.18 2198.27 2556.3599999999997 2199.3199999999997 965.14 2074.43 True False 2114.4919345828184 2217.231682551549 1498.6101026745425 2222.15685310564 2389.5520328663 2176.157399669463 2363.531707062757 2140.9868892018208 1637.772088963403 2340.703297159326 0.9033575238471969 0.9472502069110501 0.6402392411260553 0.9493543482433019 1.0208692557344865 0.929702368647254 1.009752799481735 0.914676751983098 0.6996923065605968 1.0 11.192726357580531 LDYVPSSAS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 LDYVPSSASR 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 LDYVPSSAS(1)R;LDYVPSSAS(1)R 158.56 0.00047333 51504000.0 5287.7 5984.299999999999 6116.6 6110.1 6523.6 5763.1 6643.5 5158.2 3151.0 4840.4 True False 5410.893121926862 5283.655373974404 5285.9993160788135 5043.085735782068 5933.541531835128 5705.128446476129 6142.375446287465 5021.387779805045 5347.016860065568 5461.712489488681 0.990695341862168 0.9673990317401445 0.9678281905633013 0.9233524733291473 1.0863884803996007 1.0445676987677242 1.1246244576419486 0.9193797347386811 0.9790000609435502 1.0 12.415137655721312 -6.2507847848757265 24.96671052406959 1.0275226608551855 0.9630751694861321 0.2402736465156733 0.05511203728043212 1138.6494866267435 2668173.117435108 0.017365038571240974 0.02217594885563055 5.613260728947878e-07 6.2507847848757265 -0.06444749136905337 LDYVPSSAS(ph)R ddPTM_A459_Selumetinib_30min_R2 6 LDYVPSSASR 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 LDYVPSS(0.005)AS(0.995)R;LDYVPSSAS(1)R;LDYVPSSAS(1)R;LDYVPSSAS(1)R;LDYVPSS(0.002)AS(0.998)R;LDYVPSS(0.002)AS(0.998)R 152.67 0.00062478 103809200.0 405572.0 404898.0 420781.0 428481.0 404702.0 338727.0 355951.0 349548.0 318856.0 371503.0 True False 383031.9318733526 435952.37464773026 393708.40857171244 370121.1486290472 353859.7166782157 385383.569592442 372503.4268035259 350565.1268092133 382636.10958102 360776.7431092867 1.0616868719759032 1.2083716120128933 1.0912799011893348 1.0259007979262396 0.9808274048613613 1.0682051350402635 1.0325039901219102 0.9716954695802549 1.0605897328174274 1.0 18.460746815019206 -5.632672697085412 3.650479277721049 1.0195401513078073 1.1381012707180402 0.5337934412230505 0.04407532823098415 0.15598314989445733 3.958262932681528 0.011661977072110712 0.02156161235233612 2.3298464682249174e-06 5.632672697085412 0.11856111941023295 LEAEIATYR ddPTM_A459_Selumetinib_30min_R2 1 LEAEIATYR 9 0 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 0 134.77 0.038838 6862900.0 23968.0 20298.0 22773.0 24806.0 32423.0 20830.0 19453.0 22333.0 22090.0 19494.0 False True 22635.954511506006 21854.791331643093 21307.809973367654 21427.380007263193 28349.732874702328 23699.143424086553 20357.603045388234 22397.985332572825 26508.61724616978 18931.1575685053 1.1956983839785988 1.1544350234558123 1.1255418426613413 1.1318578871748823 1.4975171366100815 1.2518591817921099 1.0753490890201047 1.1831281447804909 1.4002639379152741 1.0 14.208475008619773 LEAFHER ddPTM_A459_Selumetinib_30min_R2 1 LEAFHER 7 0 Q14151 Q14151 SAFB2 Scaffold attachment factor B2 0 98.523 0.030632 1411000.0 10871.0 10766.0 14673.0 14054.0 13944.0 8446.2 10822.0 10032.0 9977.7 14058.0 False True 10266.833340060995 11591.71758185385 13728.955154754469 12139.820955497733 12192.230059058365 9609.587383030232 11325.244443386186 10061.191459112999 11973.518800231252 13652.109012929483 0.7520327687346768 0.8490788910984889 1.0056288842809713 0.8892267812980756 0.8930656829293913 0.7038903200911518 0.8295600652368366 0.7369697568034624 0.8770453553287267 1.0 13.736836219153425 LEAHSDWVR ddPTM_A459_Selumetinib_30min_R2 2 LEAHSDWVR 9 0 P55735;A8MXL6;P55735-2;P55735-4;P55735-3 P55735 SEC13 Protein SEC13 homolog 0 ; 133.13 0.0044903 5292200.0 92883.0 93250.0 101152.0 120020.0 121226.0 96651.0 95961.0 110902.0 95711.0 105047.0 False True 87720.93470010895 100401.97515399139 94643.99044597028 103673.06895395162 105996.5061058096 109963.79793957707 100423.37664311405 111224.70645918565 114855.8743887801 102014.0201651161 0.8598909694777943 0.9841978091980346 0.9277547369742221 1.0162629488196842 1.0390386138517784 1.0779282863433257 0.9844075988827076 1.0902884356401352 1.1258832286275813 1.0 16.638407915189447 -4.698969095966275 0.5126609142656862 1.0666863328732614 0.7387917240511739 0.6210745967809074 0.04610050337476852 3.1775194658117045 0.6025360639611751 0.028120224085363014 0.6408471797549015 2.0000041832016375e-05 4.698969095966275 -0.32789460882208754 LEAS(ph)IER ddPTM_A459_Selumetinib_30min_R2 1 LEASIER 7 0 Q9UBI6 Q9UBI6 GNG12 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 1 LEAS(1)IER 85.67 0.035913 7723300.0 51958.0 16727.0 33504.0 43610.0 29908.0 24300.0 46621.0 33885.0 31550.0 26112.0 True False 49070.382364353725 18009.90711421786 31348.389116397055 37670.24276855387 26150.6896590876 27647.10442656279 48788.96887775894 33983.59974003629 37860.881580654415 25358.078712876268 1.935098590077208 0.7102236458108647 1.2362288748823482 1.4855322122423162 1.0312567428781132 1.0902681050723375 1.924001003001264 1.3401488387517377 1.493050085116642 1.0 14.630157821540628 LEAS(ph)YSDSPPGEEDLLVHVAEGSK ddPTM_A459_Selumetinib_30min_R1 4 LEASYSDSPPGEEDLLVHVAEGSK 24 0 Q7Z3C6;C9JS65;C9JFV2;F2Z3I6;C9JX27;C9IYZ9;C9JKV7;C9JDK4;C9JXG2;Q7Z3C6-3 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 LEAS(0.946)YS(0.053)DS(0.001)PPGEEDLLVHVAEGSK;LEAS(0.989)YS(0.011)DSPPGEEDLLVHVAEGSK;LEAS(0.819)YS(0.173)DS(0.008)PPGEEDLLVHVAEGSK;LEAS(0.94)YS(0.06)DSPPGEEDLLVHVAEGSK 211.66 3.8614e-32 38156100.0 10022.0 13341.8 13043.300000000001 12691.1 12833.0 11532.800000000001 13419.0 12772.3 7126.9 10560.0 True False 10255.49310058267 11779.735853565457 11272.091501718405 10474.83762645191 11672.257415850168 11416.79050294458 12406.794026301122 12433.537113722608 12093.828771818884 11915.478863110586 0.860686609275343 0.9886078426973356 0.9460040701021208 0.879094977783999 0.9795877740160815 0.9581478540732502 1.0412333544320749 1.043477753312617 1.0149679178451196 1.0 13.540549311736685 -6.938101101940527 1.7232125137236403 1.028315171171449 0.9280164589792259 0.5738860797892649 0.03847987233657332 0.2639611641051818 1.5974872024285902 0.017293913896197586 0.013768271480502197 1.1531847699754399e-07 6.938101101940527 -0.1002987121922232 LEAS(ph)YSDSPPGEEDLLVHVAEGSK ddPTM_A459_Selumetinib_30min_R2 1 LEASYSDSPPGEEDLLVHVAEGSK 24 0 Q7Z3C6;C9JS65;C9JFV2;F2Z3I6;C9JX27;C9IYZ9;C9JKV7;C9JDK4;C9JXG2;Q7Z3C6-3 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 LEAS(0.891)Y(0.004)S(0.053)DS(0.053)PPGEEDLLVHVAEGSK 87.991 0.0010173 0.0 10534.0 6072.8 8898.2 13018.0 9168.5 7400.9 8987.3 10830.0 7482.6 8427.1 True False 9948.562450943113 6538.5642328703425 8325.699499627635 11244.925942697413 8016.671062570037 8420.30679631887 9405.227257997098 10861.513506996987 8979.329081312359 8183.78772676469 1.2156427785152357 0.7989655219778341 1.0173405979726025 1.374049073379728 0.9795795455876616 1.028900929184741 1.1492511257638987 1.3271988313522505 1.0972094317580952 1.0 12.998553009227782 -5.545326897784523 24.984130137802516 1.1440341243836092 0.9825161890948896 0.11785067281103845 0.15419520089496777 375.83800216956337 418294.6241085522 0.04109528428834542 0.0711851446235621 2.848873085093292e-06 5.545326897784523 -0.1615179352887196 LEASDCDHQQNS(ph)PTLERPGR ddPTM_A459_Selumetinib_30min_R2 1 LEASDCDHQQNSPTLERPGR 20 1 B1AN62;Q9HAN9 B1AN62 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 LEAS(0.003)DCDHQQNS(0.995)PT(0.002)LERPGR 69.525 0.006616199999999999 14482000.0 20916.0 14580.0 20211.0 31258.0 25483.0 27703.0 27016.0 24121.0 21839.0 22392.0 True False 19753.572453382007 15698.239117910944 18910.646264072962 27000.60647694239 22281.597719089514 31518.836787204487 28272.297531188422 24191.1881165535 26207.4102326438 21745.484778597034 0.9083988080516114 0.721907985852857 0.8696355338412939 1.2416649595008202 1.0246539889062463 1.4494428203424954 1.3001456540998984 1.112469478738117 1.2051885942979028 1.0 14.408428251142048 -5.707796470228977 5.09655477483125 1.2040544604990775 0.8128309655281144 0.6086551941552734 0.13108683463950713 0.12346776969775602 6.698682665634326 0.03605410840186716 0.062473755928796705 1.959762890659213e-06 5.707796470228977 -0.3912234949709631 LEASYS(ph)DSPPGEEDLLVHVAEGSK ddPTM_A459_Selumetinib_30min_R2 1 LEASYSDSPPGEEDLLVHVAEGSK 24 0 Q7Z3C6;C9JS65;C9JFV2;F2Z3I6;C9JX27;C9IYZ9;C9JKV7;C9JDK4;C9JXG2;Q7Z3C6-3 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 LEAS(0.116)Y(0.003)S(0.441)DS(0.441)PPGEEDLLVHVAEGSK 102.28 2.1954e-06 2378100.0 21906.0 16333.0 24964.0 27650.0 28840.0 20936.0 24883.0 22480.0 19191.0 26551.0 True False 20688.552216666016 17585.688581127517 23357.84341874809 23884.02230108953 25216.861367128728 23819.74396191435 26040.108804729105 22545.41307823566 23029.73624134198 25784.4036422173 0.8023669076756249 0.6820281292965074 0.905890387959326 0.9262972544373205 0.9779889314888274 0.923804338949838 1.009917047764996 0.8743817926167436 0.8931653630970525 1.0 14.654211057920975 -5.377499995553337 4.91783807190761 0.9399586531602062 0.7436103518108835 0.7194304364747892 0.049463389911273185 0.10643615948026598 3.8157849856352053 0.012822329452370333 0.02772921295957548 4.19276000977497e-06 5.377499995553337 -0.19634830134932268 LEASYSDS(ph)PPGEEDLLVHVAEGSK ddPTM_A459_Selumetinib_30min_R1 2 LEASYSDSPPGEEDLLVHVAEGSK 24 0 Q7Z3C6;C9JS65;C9JFV2;F2Z3I6;C9JX27;C9IYZ9;C9JKV7;C9JDK4;C9JXG2;Q7Z3C6-3 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 LEAS(0.07)YS(0.246)DS(0.683)PPGEEDLLVHVAEGSK;LEAS(0.055)YS(0.232)DS(0.712)PPGEEDLLVHVAEGSK 190.54 1.4284e-26 41628000.0 11859.3 12592.4 13556.4 12468.0 13681.8 11648.5 11710.9 12085.4 6127.6 9958.2 True False 12135.598615819206 11118.075953952068 11715.515339974947 10290.69785334623 12444.28360571798 11531.326665991777 10827.537384500318 11764.855933088264 10398.089657803164 11236.431971082186 1.0800224347952352 0.9894667615632154 1.0426366101023634 0.9158332360156788 1.1074942328440462 1.0262445138873733 0.9636099263864019 1.0470277365062164 0.9253907009416726 1.0 13.455896372864276 -8.255792570185976 24.971363799531435 0.9626953503327201 1.0187430542649738 0.1529842836816805 0.05507231707232469 782.7877890588785 3461689.9629302705 0.03767414183126567 0.013357176972590019 5.5489067922400605e-09 8.255792570185976 0.05604770393225367 LECGGGPWGNK ddPTM_A459_Selumetinib_30min_R1 2 LECGGGPWGNK 11 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 190.02 0.00027346 44579000.0 3485.5 3689.6 3932.9 4076.2 3885.7 3248.2 3619.8 3375.1000000000004 2150.38 2956.4 False True 3566.705368397615 3257.619916751495 3398.833781873321 3364.368189750552 3534.239121076056 3215.526057129629 3346.7555716823013 3285.5813841301233 3649.037802458837 3335.882737774632 1.069193868240394 0.97653909709208 1.0188708803777329 1.0085391047033394 1.059461437614485 0.9639205901088439 1.0032593573462725 0.9849211265507298 1.093874722015292 1.0 11.703852861033283 -8.237477599633419 24.973987505344084 1.046937412051908 1.0094902300220734 0.1278012484065869 0.03789672181730405 1284.145411119901 1338394.6823848751 0.024086442998593676 0.00909376412797988 5.787918409389974e-09 8.237477599633419 -0.03744718202983455 LECGGGPWGNK ddPTM_A459_Selumetinib_30min_R2 1 LECGGGPWGNK 11 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 187.22 0.00026702 26497000.0 25232.0 22011.0 27105.0 25767.0 25804.0 15309.0 21544.0 15744.0 13741.0 20601.0 False True 23829.706451698934 23699.172923479964 25361.09380969264 22257.49014944572 22562.270829313115 17417.675788734563 22545.838688626132 15789.812433440491 16489.583955618782 20006.19560217387 1.1911163384361594 1.1845916832336087 1.2676619940143397 1.112529867848899 1.1277641825546034 0.8706140905091402 1.1269428299589506 0.7892461289204217 0.8242238696210201 1.0 14.288159228567132 -6.647359117809891 0.9855037918902115 0.8913760794131095 1.216447442195777 0.6273228213423838 0.09747072636908195 0.336823628405181 0.7078068904400481 0.052642869631433206 0.05409849454805421 2.2523759537602247e-07 6.647359117809891 0.32507136278266746 LEDEQPS(ph)TLSPK ddPTM_A459_Selumetinib_30min_R2 1 LEDEQPSTLSPK 12 0 A0A1W2PNX9;A0A1W2PRA7;A0A1W2PRB0;A0A1W2PNW6;A0A1W2PPY5;Q12791-2;Q5SVJ7;A0A1W2PQ93;H0Y379;H0Y382;A0A1W2PQ61;A0A1W2PQU4;Q12791-5;A0A1W2PSD3;A0A1W2PNQ3;A0A1W2PQK5;D5MRH1;S4R2X4;A0A1W2PNY8;A0A1W2PQA0 A0A1W2PNX9 KCNMA1 1 LEDEQPS(0.903)T(0.049)LS(0.049)PK 88.28200000000002 0.032524000000000004 0.0 21252.0 22643.0 20014.0 23251.0 22000.0 14624.0 25221.0 18910.0 13987.0 18606.0 True False 20070.898918496572 24379.64529127965 18726.321029595583 20084.173689787815 19236.16331750458 16638.323256545445 26393.8264744634 18965.02496928097 16784.790829433085 18068.796435806362 1.110804418534635 1.3492678041890647 1.0363900604074672 1.1115390978663993 1.0646067869459686 0.9208318504033731 1.4607407066781488 1.0496008982479088 0.9289379560539625 1.0 14.14121279090291 -1.522878985923288 0.08308910579590972 0.9000382608359818 1.6854629562455652 0.0981234151592334 0.1565125867418531 481.37770717123715 2.9150616552046156 3.980479832257535 43.27625461432087 0.029999983376978488 1.522878985923288 0.7854246954095834 LEDLDTCMMT(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 LEDLDTCMMTPK 12 0 Q5VZK9-2;Q5VZK9 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 LEDLDT(0.001)CMMT(0.999)PK;LEDLDT(0.001)CMMT(0.999)PK;LEDLDT(0.001)CMMT(0.999)PK;LEDLDT(0.002)CMMT(0.998)PK 156.24 0.0010138 91313600.0 14294.5 16223.6 12853.5 12643.6 12184.0 11785.6 14367.300000000001 14169.3 8387.7 15167.899999999998 True False 14627.53403774487 14324.13336985299 11108.065299221631 10435.632609766479 11081.959351259913 11667.047564468623 13283.562993820417 13793.484135627077 14233.314286630273 17114.84771285749 0.8546692487807513 0.8369419120856109 0.6490309166395166 0.6097414820656999 0.6475055774486744 0.6816915791604609 0.7761426345524052 0.80593671454434 0.8316354621103365 1.0 14.06296083491895 -8.482868356950432 0.9602176566715583 0.9951825085650747 0.7117340884232672 0.5528930495597859 0.07705374885837749 0.4856954338445037 0.9901911416188847 0.0834610651313025 0.028410519508913035 3.289513272690649e-09 8.482868356950432 -0.2834484201418075 LEDLDTCMMT(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 LEDLDTCMMTPK 12 0 Q5VZK9-2;Q5VZK9 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 LEDLDT(0.005)CMMT(0.995)PK;LEDLDT(0.002)CMMT(0.998)PK;LEDLDT(0.002)CMMT(0.998)PK 149.32 0.0013544 28726000.0 155710.0 109384.0 129728.0 134669.0 135513.0 113903.0 135056.0 132639.0 96237.0 111860.0 True False 147056.26155651713 117773.40107500454 121381.44171716656 116326.84988301712 118488.64543840908 129592.10434151364 141336.37160838698 133024.95753043133 115487.08908644825 108630.31115281639 1.3537313848769594 1.0841670232291432 1.1173809632784024 1.0708507473514788 1.0907512293849957 1.1929644955099974 1.301076744680968 1.2245657415387279 1.063120300962648 1.0 16.729067189442077 -8.465343281642227 4.607237730848982 1.0008126327842644 1.1716237921687174 0.3108276094454865 0.08977968255585346 0.24842313808616104 10.621673268687324 0.0914620184924291 0.02386151341092061 3.4249695787560645e-09 8.465343281642227 0.17081115938445302 LEDLEVIQHR ddPTM_A459_Selumetinib_30min_R2 1 LEDLEVIQHR 10 0 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 132.25 0.0034734 1424700.0 18719.0 14937.0 17970.0 19882.0 24509.0 16776.0 20757.0 23546.0 20928.0 17652.0 False True 17678.67291809418 16082.619869975017 16813.829764256643 17174.037301636978 21429.960306760007 19086.741722634448 21722.24162921521 23614.514961749857 25114.184777177063 17142.34089459606 1.0312869768951565 0.9381810785856495 0.9808362736245098 1.0018490127594482 1.2501186645702265 1.1134267974248104 1.2671689218397773 1.377554857119548 1.4650382308692766 1.0 14.06527651154512 -6.483675997760374 1.0651722476227874 1.3007011104753936 0.9657876557024881 0.48817463553936113 0.12547199542706833 0.39279683074314453 0.9490423787402655 0.05953375255102025 0.07157105919248319 3.2834015754863714e-07 6.483675997760374 -0.33491345477290546 LEDNDSAAS(ph)DPDAETTAR ddPTM_A459_Selumetinib_30min_R2 2 LEDNDSAASDPDAETTAR 18 0 F8WF85;C9J6R3;C9J9X8;C9JCX6;C9JXA0;Q9BYV8-5;Q9BYV8-2;Q9BYV8 F8WF85 CEP41 Centrosomal protein of 41 kDa 1 LEDNDS(0.112)AAS(0.873)DPDAET(0.012)T(0.004)AR;LEDNDS(0.061)AAS(0.936)DPDAET(0.003)TAR 184.97 3.0524e-10 15977300.0 41277.0 43166.0 46822.0 51635.0 56898.0 39893.0 39762.0 42484.0 32316.0 46807.0 True False 38982.98958492298 46476.693399433694 43809.52349593904 44602.22392465672 49749.964565426155 45387.89863740205 41611.01178690828 42607.62140639519 38780.102984482706 45455.56029080882 0.8576066236016763 1.0224644268400174 0.9637879989964041 0.9812270190776936 1.0944747847599554 0.9985114768584109 0.9154218212402518 0.9373467433644309 0.8531432180437583 1.0 15.472169160510692 -7.261957470816908 24.575188710277764 0.9212568377781557 0.9916441478312037 0.16689123299484865 0.06446286771385275 60.27555218310166 2858990.0542684686 0.025719411414166036 0.018535693363143993 5.470695331835824e-08 7.261957470816908 0.07038731005304799 LEDNPSSGS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 LEDNPSSGSPPR 12 0 Q05D32;H0YMH7;Q05D32-2 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 LEDNPS(0.001)S(0.003)GS(0.996)PPR 131.08 0.0020759 8218600.0 2508.0 2982.6 2448.9 2192.7 2825.6 2163.8 2597.3 2474.3 1466.4 2436.3 True False 2566.431520281517 2633.395805426879 2116.3528308448163 1809.7861070766978 2570.024978900198 2142.034136573209 2401.3835699017727 2408.6735263408987 2488.3736983815124 2749.022836571621 0.9335795563932751 0.9579388611813268 0.7698564023150043 0.6583379675862314 0.9348867331001673 0.7791983784480292 0.8735407861859021 0.8761926217189301 0.9051848043157142 1.0 11.424703176260783 -8.575585503740784 1.0046705769342963 0.9988916389915844 0.8380405004407498 0.236124281663197 0.08618387641534915 0.97136151292423 2.134088746070255 0.08695746810435567 0.02875124502898525 2.6571403612185447e-09 8.575585503740784 -0.16085113855083455 LEDNPSSGS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 3 LEDNPSSGSPPR 12 0 Q05D32;H0YMH7;Q05D32-2 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 LEDNPS(0.008)S(0.041)GS(0.951)PPR;LEDNPS(0.001)S(0.009)GS(0.99)PPR;LEDNPS(0.052)S(0.158)GS(0.79)PPR 124.47 0.0030444 20174500.0 68242.0 74740.0 69540.0 70336.0 72519.0 69500.0 64956.0 65186.0 56940.0 84910.0 True False 64449.382834370495 80472.31767302207 65065.87210942721 60756.11546363228 63408.51489191434 79072.99414181535 67976.58270787216 65375.680467876795 68329.59103652817 82458.42767732544 0.7815984933228711 0.9759138021394809 0.789074857988338 0.7368090463885852 0.7689755514141403 0.9589437534661963 0.8243739860512097 0.7928320040700207 0.8286550321322409 1.0 16.331379331634608 LEDTAGDTGHSSLEAPRS(ph)PDTLAPVASER ddPTM_A459_Selumetinib_30min_R2 1 LEDTAGDTGHSSLEAPRSPDTLAPVASER 29 1 O43310;O43310-2 O43310 CTIF CBP80/20-dependent translation initiation factor 1 LEDTAGDT(0.001)GHS(0.003)S(0.016)LEAPRS(0.849)PDT(0.099)LAPVAS(0.032)ER 40.492 0.037108 5594500.0 4259.7 3127.0 5721.9 9586.4 13518.0 5700.1 4959.8 6360.3 7653.7 8172.9 True False 4022.9629269301654 3366.830845110256 5353.759183533676 8280.7157825376 11819.747987546683 6485.237034644054 5190.440527657251 6378.807419995655 9184.6538622458 7936.9271412556145 0.506866556203984 0.42419828041632074 0.6745380281627124 1.0433150809076972 1.489209586681025 0.8170967074819456 0.6539609643986385 0.8036872843192729 1.157205263294479 1.0 12.954364846672753 -5.577160249195241 3.686875237016545 0.9844114539374642 0.4761089024881177 0.5028571080407733 0.2154647094708111 0.2054722107603459 5.720893266877883 0.06641011723909562 0.12735767939829515 2.6475230556818708e-06 5.577160249195241 -0.5083025514493464 LEDTENWLYEDGEDQPK ddPTM_A459_Selumetinib_30min_R2 1 LEDTENWLYEDGEDQPK 17 0 A0A087WYC1;P34932 A0A087WYC1 HSPA4 Heat shock 70 kDa protein 4 0 131.53 0.010756 4684500.0 24463.0 28098.0 28158.0 25135.0 28804.0 19832.0 23603.0 22580.0 16239.0 25955.0 False True 23103.44439314802 30253.02625069008 26346.34493611234 21711.56963970652 25185.384008972833 22563.67798302854 24700.58626845722 22645.704061679764 19487.253755570437 25205.611710811263 0.916599234258553 1.20024963479517 1.0452571133122626 0.8613784060790689 0.99919749212713 0.895184701006501 0.9799637696498583 0.8984389794422845 0.7731315541614849 1.0 14.621457346848324 -5.657506092675154 6.1343614762405325 0.9168005943177732 1.073179869916128 0.3242710471832274 0.09114888527657544 0.21749539543905633 11.110962333749914 0.023891436498229793 0.0417029200808073 2.2003608407720993e-06 5.657506092675154 0.15637927559835474 LEDVKNS(ph)PTFK ddPTM_A459_Selumetinib_30min_R1 1 LEDVKNSPTFK 11 1 H0YC42;P55327-2;P55327;P55327-3 H0YC42 TPD52 Tumor protein D52 1 LEDVKNS(0.997)PT(0.003)FK 135.94 0.006914399999999999 15824000.0 1337.8 1846.9 1999.4 2013.8 1710.5 1759.1 2365.4 2233.7 1598.9 1675.7 True False 1368.9681370943429 1630.6640893994834 1727.8924619180543 1662.1276337077836 1555.7855770133026 1741.405051135007 2186.9759736055357 2174.455019919842 2713.2165209644027 1890.7924177002276 0.7240182075404237 0.8624236453110287 0.9138456690130434 0.8790640464538306 0.8228219885214083 0.9209921908048898 1.1566451997229588 1.1500231329278512 1.4349626619851217 1.0 10.88477526910625 -7.260201122127099 2.2142748441461113 1.2173034925548538 0.8465711884886014 0.69051039906575 0.10974909139685345 0.1739345732688053 1.6697366285656439 0.05165311363389592 0.03361366317927314 5.49286439951684e-08 7.260201122127099 -0.37073230406625246 LEEEDEDEEDGESGCTFLVGLIQK ddPTM_A459_Selumetinib_30min_R1 1 LEEEDEDEEDGESGCTFLVGLIQK 24 0 P17655;P17655-2 P17655 CAPN2 Calpain-2 catalytic subunit 0 70.76 0.015194999999999997 0.0 407.94 244.15 502.64 565.44 287.87 372.51 359.69 374.6 224.92 268.12 False True 417.44420828693853 215.56480449774438 434.38424880388675 466.6965186233634 261.83220932757627 368.7628876120183 332.5582937119198 364.66439112771303 381.67281249316045 302.53581370996307 1.379817493895571 0.7125265662081363 1.4358109986288268 1.5426157746427303 0.8654585588289763 1.2189065588299117 1.0992361189698316 1.2053594140008554 1.2615789443661203 1.0 8.2409621262229 -5.288591058546986 24.998878976521812 1.207802662990302 1.0461715615874472 0.06571592200913878 0.23704759063897113 1830.8625869382797 1685694.1321767927 0.06088176668901832 0.1267857295206816 5.145279146081549e-06 5.288591058546986 -0.16163110140285486 LEEEDEDEEDGESGCTFLVGLIQK ddPTM_A459_Selumetinib_30min_R2 3 LEEEDEDEEDGESGCTFLVGLIQK 24 0 P17655;P17655-2 P17655 CAPN2 Calpain-2 catalytic subunit 0 ;; 81.017 0.00032312 2015260.0 20278.8 19290.3 24945.0 25255.7 23470.7 18106.5 16555.0 18177.7 15438.8 19184.5 False True 19151.785478468304 20769.803981909277 23340.065858062433 21815.83009148743 20522.10083527977 20600.506020557998 17324.840303110166 18230.594097519777 18526.99139611435 18630.593637682854 1.0279750528040754 1.114822446661044 1.2527816510824457 1.170968060156817 1.1015269418882654 1.1057353523556401 0.9299134874622766 0.9785299627085406 0.9944391336323843 1.0 14.185386024011308 -7.1280404512162985 4.1410345462228095 0.9744107849184973 1.1385448576776895 0.6412425675347959 0.05625027833286148 0.15924596767391133 4.579231301245984 0.024149499543789803 0.018493611087432405 7.446626110370416e-08 7.1280404512162985 0.16413407275919223 LEEELDDLLVDLDHQR ddPTM_A459_Selumetinib_30min_R1 1 LEEELDDLLVDLDHQR 16 0 P35579-2 P35579-2 MYH9 Myosin-9 0 166.04 2.4041e-05 4879000.0 1808.7 2159.0 1901.5 2159.1 1912.8 1668.6 2099.9 1778.6 1010.4 1557.5 False True 1850.8391908824472 1906.2232763081295 1643.286744191849 1782.0537163265844 1739.7875777322697 1651.815398967582 1941.5028523608105 1731.4257502929813 1714.575003303792 1757.4202963347282 1.05315683148906 1.0846712538165995 0.9350562000558911 1.0140168063628443 0.989966703673997 0.9399091397843786 1.1047458916970543 0.9852086913438061 0.9756203492583453 1.0 10.779243545402233 -5.237115380900179 24.950761350081105 0.9952649452461585 1.0689140582967473 0.31361461712919114 0.04478971032263622 930.1336957438117 954096.9390268185 0.011268938808924874 0.029783568967749 5.792747775369905e-06 5.237115380900179 0.07364911305058885 LEEEPSASS(ph)PQYACDFNLFLEDSADNR ddPTM_A459_Selumetinib_30min_R1 2 LEEEPSASSPQYACDFNLFLEDSADNR 27 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 LEEEPS(0.031)AS(0.157)S(0.812)PQYACDFNLFLEDSADNR;LEEEPS(0.013)AS(0.193)S(0.794)PQYACDFNLFLEDSADNR 163.06 1.1799000000000002e-17 25302000.0 6016.6 7802.9 5607.8 4800.799999999999 6663.2 5996.4 7490.700000000001 8255.7 3976.2 6685.0 True False 6156.775073734355 6889.332840530206 4846.291561440469 3962.4304021771422 6060.514736483505 5936.081660295581 6925.670468202835 8036.732017707047 6747.320989842177 7543.084867414227 0.8162144774920053 0.9133309463733864 0.6424813781926572 0.5253063530140906 0.8034530756328414 0.7869567643258497 0.9181482894513632 1.0654436691313593 0.8945041860778059 1.0 12.880938942471584 -7.247139596753909 2.1385044752447113 0.9874729953859928 0.7341911455424656 0.5243023213924984 0.10539776885716665 0.2840257901861492 2.540753770708817 0.056618620385502395 0.03696658138889256 5.660573100643973e-08 7.247139596753909 -0.2532818498435272 LEEFS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LEEFSPR 7 0 Q9UGU0-2;Q9UGU0;I3L1M7 Q9UGU0-2 TCF20 Transcription factor 20 1 LEEFS(1)PR 98.582 0.021764 2172100.0 14659.0 15462.0 19032.0 23114.0 23537.0 14769.0 18832.0 16038.0 15672.0 19418.0 True False 13844.31146462645 16647.885681833955 17807.501840474833 19965.833326125987 20580.071636550256 16803.2956903665 19707.72531490008 16084.667924766174 18806.837912266772 18857.351885976997 0.7341598941536206 0.8828326364431859 0.9443267510809473 1.0587824550791405 1.091355337747838 0.8910739849353945 1.0450950607521647 0.8529653591884929 0.9973212583603646 1.0 14.20283947395034 -4.860405438699215 1.787211933558627 0.9863766781004946 0.677342950611222 0.5621990457752783 0.06927464272251105 0.563510218253186 2.110213860577784 0.01953987952991748 0.2833806514473773 1.3790961984003508e-05 4.860405438699215 -0.3090337274892726 LEEGVAS(ph)DEEAEEAQPGSGPSPEPEGSPPAHPQ ddPTM_A459_Selumetinib_30min_R2 2 LEEGVASDEEAEEAQPGSGPSPEPEGSPPAHPQ 33 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-4;A1L2Z2 Q7Z406 MYH14 Myosin-14 1 LEEGVAS(1)DEEAEEAQPGSGPSPEPEGSPPAHPQ;LEEGVAS(1)DEEAEEAQPGSGPSPEPEGSPPAHPQ 111.59 2.2138999999999998e-14 14497000.0 32066.0 30931.0 40961.0 44059.0 40097.0 32076.0 31137.0 31064.0 24266.0 34914.0 True False 30283.900090368486 33303.308241159335 38325.61385496475 38058.08819398567 35059.65638827189 36494.17784306289 32584.932196795016 31154.39109707795 29119.878048689734 33905.94210253377 0.8931738277257716 0.9822263053611066 1.1303509496673356 1.1224607202742085 1.0340269054388522 1.0763357565084646 0.9610389853865752 0.9188475283437059 0.8588429119777686 1.0 15.049250511041611 -7.455328677726412 3.739446479760484 0.9187879038476544 1.0444873657233313 0.3427823208768602 0.07190876799785369 0.26915864780691273 7.3311061993986755 0.03571633723815432 0.02217267951576688 3.504865223991998e-08 7.455328677726412 0.12569946187567693 LEEPEEPKVLT(ph)PEEQLADK ddPTM_A459_Selumetinib_30min_R1 1 LEEPEEPKVLTPEEQLADK 19 1 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 LEEPEEPKVLT(1)PEEQLADK 100.85 0.0017095 7079600.0 1160.6 1201.5 1284.8 1589.7 1123.8 1177.6 1182.4 968.99 560.95 1094.9 True False 1187.6397218655213 1060.8278214378042 1110.331216901229 1312.0887373648134 1022.1524884230046 1165.754413175251 1093.210616044299 943.2892374768891 951.891179832999 1235.4410802291463 0.961308265421481 0.8586632243449802 0.8987326345788079 1.0620407224288273 0.8273583457605428 0.9435936944552872 0.884874749220362 0.7635242607457494 0.7704869095468678 1.0 10.270810492991151 -7.543569278765459 9.899006348877936 0.8249161327671484 0.9221166116945315 0.14128049909941343 0.08515546528312705 0.5029807780502651 226.28240494797672 0.03836709966632367 0.022341350535689218 2.8604260283484463e-08 7.543569278765459 0.09720047892738315 LEEPES(ph)TK ddPTM_A459_Selumetinib_30min_R2 1 LEEPESTK 8 0 Q96GE4 Q96GE4 CEP95 Centrosomal protein of 95 kDa 1 LEEPES(0.879)T(0.121)K 80.23100000000002 0.046646 6766100.0 9932.0 11249.0 50588.0 45516.0 91860.0 43078.0 13364.0 26335.0 58616.0 37539.0 True False 9380.019200946166 12111.76212876407 47333.223156049826 39316.64228052051 80319.7255611805 49011.60347685068 13985.452480263619 26411.630490006057 70340.83786788078 36455.15153196473 0.2573029820688455 0.3322373277791534 1.298396006241997 1.0784934536905368 2.203247612090003 1.3444355987349597 0.3836344629647431 0.7244965218934207 1.929517089133597 1.0 15.153835077900672 -5.256746366614907 19.570725507927147 1.2364633426103513 0.29476703229147244 0.36594051055599075 0.5003591847147846 21.918260555136 91379.09560307892 0.13690450639015966 0.33411413053062095 5.536733669536975e-06 5.256746366614907 -0.9416963103188789 LEEPPELNRQS(ph)PNPR ddPTM_A459_Selumetinib_30min_R1 4 LEEPPELNRQSPNPR 15 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 LEEPPELNRQS(1)PNPR;LEEPPELNRQS(1)PNPR;LEEPPELNRQS(1)PNPR;LEEPPELNRQS(1)PNPR 92.906 0.007161 330142800.0 7547.0 9368.0 8744.599999999999 9878.2 9097.4 7678.360000000001 8513.599999999999 8174.9 4290.2 6860.9 True False 7722.830416094342 8271.190204934957 7557.131350649506 8153.157806779334 8274.541776276421 7601.1226697930715 7871.412297661317 7958.075096182436 7280.156056189562 7741.563345825325 0.9975802135958644 1.068413424453245 0.9761763888071426 1.0531668401545746 1.0688463565616249 0.9818588740079242 1.0167729625187416 1.0279674454222307 0.940398693516526 1.0 12.918409220995732 -8.242526234635452 24.363478179935964 0.9701993475886177 1.0245860826740487 0.28674702634070803 0.033828589205344414 619.8502671522523 798480.1822655563 0.02211454772958258 0.008324281976573098 5.721023943442489e-09 8.242526234635452 0.054386735085431015 LEEPPELNRQS(ph)PNPR ddPTM_A459_Selumetinib_30min_R2 2 LEEPPELNRQSPNPR 15 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 LEEPPELNRQS(1)PNPR;LEEPPELNRQS(1)PNPR 99.941 0.00435 121839000.0 86467.0 84756.0 98298.0 97751.0 98900.0 67784.0 67155.0 80036.0 61052.0 85432.0 True False 81661.51029482599 91256.51266650637 91973.61369877003 84437.14517011956 86475.29782278198 77120.63071811247 70277.84056510797 80268.89150932684 73264.10593540789 82965.35618100675 0.9842844538226758 1.099935164111279 1.108578543291128 1.0177398019710997 1.0423061118922643 0.9295522163474745 0.8470745356866999 0.9674989080285874 0.8830686603160782 1.0 16.34022141601418 -6.752758588999543 4.139264082493661 0.9169795275979362 1.056539596607539 0.592449497411504 0.05177201092396249 0.13757307316020959 5.370230904408996 0.017854033701108066 0.016803125527698606 1.7670197799138431e-07 6.752758588999543 0.13956006900960283 LEEPTPAPSTS(ph)YSPQADSLR ddPTM_A459_Selumetinib_30min_R1 1 LEEPTPAPSTSYSPQADSLR 20 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 LEEPTPAPS(0.198)T(0.198)S(0.424)Y(0.001)S(0.179)PQADSLR 202.61 6.487e-16 33847000.0 1493.2 1647.6 1542.2 2139.2 1726.2 1154.4 1532.7 1477.2 671.57 1226.1 True False 1527.98865473858 1454.6982260515404 1332.7777106982217 1765.6288777573184 1570.0655147853636 1142.787784111337 1417.0872050161513 1438.0198573781581 1139.6052404678621 1383.4818782253685 1.104451513812797 1.0514761696174315 0.9633503204305166 1.2762211818937164 1.1348652551917278 0.8260229512924473 1.0242903989706675 1.0394208120909736 0.8237225643531133 1.0 10.434088031345322 -6.736877863790346 24.99755745532522 0.9502550368405337 1.1045634320324111 0.3979872786218399 0.10024692401445678 263.3183806827743 267992.4616991932 0.033907891598326675 0.03389268022668797 1.8328297948180496e-07 6.736877863790346 0.15430839519187745 LEEPTPAPSTSYS(ph)PQADSLR ddPTM_A459_Selumetinib_30min_R1 4 LEEPTPAPSTSYSPQADSLR 20 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 LEEPTPAPS(0.093)T(0.093)S(0.307)YS(0.506)PQADSLR;LEEPTPAPS(0.045)T(0.016)S(0.309)YS(0.63)PQADSLR;LEEPTPAPSTS(0.002)YS(0.998)PQADSLR;LEEPTPAPS(0.006)T(0.006)S(0.006)YS(0.979)PQADS(0.001)LR 288.96 1.2275999999999992e-85 556352400.0 11533.729999999998 13284.979999999998 14356.0 15715.61 13947.1 11393.53 12151.77 11770.580000000002 6434.93 9598.090000000002 True False 11802.443468268157 11729.56836558035 12406.534051863362 12971.173732036134 12685.5872675605 11278.921432697534 11235.152205453851 11458.385982167742 10919.606221308075 10830.098344813743 1.0897817445877622 1.0830528026735178 1.1455606086720842 1.1976967631367537 1.1713270612759767 1.0414421987311613 1.037400755537375 1.0580131054539195 1.0082647334903654 1.0 13.402758723227997 -6.810252612079508 8.098792491586433 1.0327424506725988 1.1381869855445108 0.7017269728699935 0.035318761138125286 0.16848275342753327 24.66197573704269 0.014029944628658768 0.012430552963614803 1.5479159949398e-07 6.810252612079508 0.10544453487191197 LEEPTPAPSTSYS(ph)PQADSLR ddPTM_A459_Selumetinib_30min_R2 6 LEEPTPAPSTSYSPQADSLR 20 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 LEEPTPAPST(0.002)S(0.014)YS(0.983)PQADSLR;LEEPTPAPST(0.002)S(0.029)YS(0.969)PQADSLR;LEEPTPAPS(0.004)T(0.004)S(0.015)YS(0.977)PQADSLR;LEEPTPAPS(0.02)T(0.106)S(0.42)Y(0.009)S(0.445)PQADSLR;LEEPTPAPS(0.003)T(0.003)S(0.012)YS(0.981)PQADSLR;LEEPTPAPS(0.001)T(0.001)S(0.007)Y(0.001)S(0.989)PQADSLR 306.67 9.121199999999995e-102 554562700.0 362586.0 365206.0 439300.0 459926.0 472135.0 314385.0 352746.0 361434.0 312440.0 372961.0 True False 342434.92166676105 393216.1258776261 411035.9162736746 397283.28538339725 412821.18035954685 357688.68004711735 369149.38795293885 362485.71310138056 374936.73030300054 362192.64686094614 0.9454496788782945 1.0856546351383842 1.134854392644477 1.0968839064695954 1.1397834382817775 0.9875647204523234 1.0192072952123281 1.0008091446443608 1.035185925370117 1.0 18.46639773181012 -6.777925015625151 24.99759903591516 1.009269846974208 1.0847372919637537 0.32678390159786797 0.051468687268716354 295.455067333299 448003.2494977715 0.01863835957527427 0.016482407021228808 1.6675351008121673e-07 6.777925015625151 0.0754674449895456 LEFQQQLGEAPSDAS(ph)P ddPTM_A459_Selumetinib_30min_R1 2 LEFQQQLGEAPSDASP 16 0 Q9BUW7 Q9BUW7 C9orf16 UPF0184 protein C9orf16 1 LEFQQQLGEAPS(0.02)DAS(0.98)P;LEFQQQLGEAPSDAS(1)P 158.89 6.5544e-05 9776700.0 2296.7 2732.4 2700.2 2874.1000000000004 2775.7 2504.3 2548.1 2193.78 1285.31 2185.26 True False 2350.2086413997426 2412.4893377417034 2333.5276711369065 2372.1923885388533 2524.638425089638 2479.109015722471 2355.8947655129214 2135.593827998276 2181.0771946718105 2465.7594072349475 0.9531378586669244 0.978396079789074 0.94637281491858 0.9620534678194664 1.02387865486062 1.0054139947508074 0.9554438922955479 0.8660998399649573 0.8845458272498801 1.0 11.267816322471598 -7.565844516676399 7.737287863884275 0.9068993924499095 0.9783215497050639 0.317043355557722 0.039450991553656875 0.23604536809691049 35.91731393157941 0.018552930000424815 0.010702028064807103 2.7174119651039318e-08 7.565844516676399 0.07142215725515444 LEFQQQLGEAPSDAS(ph)P ddPTM_A459_Selumetinib_30min_R2 1 LEFQQQLGEAPSDASP 16 0 Q9BUW7 Q9BUW7 C9orf16 UPF0184 protein C9orf16 1 LEFQQQLGEAPS(0.003)DAS(0.997)P 110.38 0.0031682 0.0 2320.4 2260.6 4190.8 6549.1 4088.1 3692.0 1899.2 1997.9 5714.6 3765.8 True False 2191.441457297171 2433.9807510253395 3921.168490598041 5657.101282172351 3574.516329922294 4200.539487360897 1987.5165631934055 2003.71355822985 6857.679679264906 3657.0715692765575 0.599233954212901 0.6655545851148956 1.072215409602642 1.54689378509796 0.9774258617064487 1.1486074056220474 0.5434721540291256 0.5479011061919756 1.8751833398276898 1.0 11.836473145311844 -5.242260717553718 5.748186701580791 1.0684024887778287 0.6254148480847088 0.18611355497215631 0.38041391304492356 0.3049352961139603 36.68933299208252 0.10019785082233892 0.25582465746755056 5.7245227077345185e-06 5.242260717553718 -0.4429876406931199 LEGDS(ph)DVDSELEDRVDGVK ddPTM_A459_Selumetinib_30min_R1 1 LEGDSDVDSELEDRVDGVK 19 1 Q92614;Q92614-2 Q92614 MYO18A Unconventional myosin-XVIIIa 1 LEGDS(0.997)DVDS(0.003)ELEDRVDGVK 93.062 0.0011621 2430000.0 1395.0 1309.0 998.85 1404.8 1188.3 1311.8 1426.5 1366.6 711.2 1057.5 True False 1427.5007858025183 1155.74167146241 863.2116562903113 1159.4780513619498 1080.8184748114045 1298.604483019102 1318.8979565182613 1330.353328657589 1206.8544560071825 1193.2404259222951 1.1963228489339486 0.9685740160614312 0.7234180451295944 0.9717053044576082 0.905784325883867 1.0883007772849864 1.1053078054230698 1.1149080267116451 1.0114092933738519 1.0 10.22066904549818 -6.767317756180988 24.90069264591547 1.0737496167003555 0.9422839402710266 0.1885400755751453 0.11293983350711372 210.92531263816548 893469.4839443986 0.04079587984151124 0.036919290684534166 1.7087646217782799e-07 6.767317756180988 -0.13146567642932894 LEGDSDDLLEDS(ph)DSEEHSR ddPTM_A459_Selumetinib_30min_R1 4 LEGDSDDLLEDSDSEEHSR 19 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 LEGDS(0.073)DDLLEDS(0.895)DS(0.026)EEHS(0.006)R;LEGDS(0.076)DDLLEDS(0.697)DS(0.219)EEHS(0.007)R;LEGDSDDLLEDS(0.999)DS(0.001)EEHSR;LEGDSDDLLEDS(0.976)DS(0.02)EEHS(0.004)R 217.67 4.317e-19 77976000.0 7622.27 9032.3 7381.7 6704.360000000001 7922.3099999999995 7338.6 7877.9 8246.949999999999 3997.7 7001.2 True False 7799.854060644415 7974.794116997652 6379.305684775686 5533.56938242383 7205.738459297436 7264.780346915673 7283.663660466325 8028.214096131054 6783.804919544311 7899.872217463051 0.9873392690330431 1.0094839381539593 0.8075201103473447 0.7004631505547148 0.9121335460805051 0.9196073236294283 0.9219976551475647 1.0162460702065912 0.8587233733412017 1.0 12.947613602164065 -6.886238922834284 2.4719289276711245 0.9485429754270237 0.8756104537499069 0.10608045278170553 0.09089938242884923 0.7378529372338715 9.170392515218264 0.039745877839823036 0.034055108562429645 1.2994544992528376e-07 6.886238922834284 -0.07293252167711683 LEGDSDDLLEDS(ph)DSEEHSR ddPTM_A459_Selumetinib_30min_R2 2 LEGDSDDLLEDSDSEEHSR 19 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 LEGDSDDLLEDS(1)DSEEHSR;LEGDSDDLLEDS(1)DSEEHSR 176.88 5.4335e-13 108230000.0 247486.0 167399.5 242613.0 272258.0 292047.0 217975.0 202242.0 227937.0 189184.0 213130.0 True False 233731.71888495382 180238.50337577026 227003.5437170612 235175.99072875304 255357.44492669354 247999.07766995954 211646.6537349206 228600.25893299846 227026.08624261638 206976.38312175655 1.1292675780669048 0.8708167601409027 1.0967606076270229 1.1362455328558316 1.2337516052567032 1.198199881210944 1.0225642681678166 1.1044750878583156 1.096869521142735 1.0 17.659106633963702 -5.4977798201875725 24.053855562650966 1.1218582706708207 0.9959787485446069 0.20003292891737312 0.08810331336969483 617.5932908365214 591875.5842258262 0.022848772166356734 0.04719004387433853 3.1784850993621985e-06 5.4977798201875725 -0.12587952212621378 LEGDSDVDS(ph)ELEDR ddPTM_A459_Selumetinib_30min_R2 1 LEGDSDVDSELEDR 14 0 Q92614;Q92614-2 Q92614 MYO18A Unconventional myosin-XVIIIa 1 LEGDS(0.24)DVDS(0.76)ELEDR 96.707 0.011608 2597000.0 11220.0 5018.5 6987.1 8222.4 9169.5 5740.4 10298.0 9605.9 8834.2 6383.3 True False 10596.437317218688 5403.40281297915 6537.557592979275 7102.494935568845 8017.545433629923 6531.087993837081 10776.877405099885 9633.851578657643 10601.286848171712 6198.997543194817 1.7093791767753361 0.8716575180628906 1.0546152902022239 1.1457489515165038 1.2933616085122481 1.0535716377250106 1.738487123120513 1.5540983056580764 1.7101614856759662 1.0 12.597819216872422 -7.254444955576923 24.98580378511223 1.5468615902001337 1.170472082700536 0.22214471423610094 0.28018026622641456 677.145030174182 2418934.694178879 0.10313651148386209 0.07814074649922607 5.566151776822618e-08 7.254444955576923 -0.37638950749959776 LEGEVT(ph)PNSLSTSYK ddPTM_A459_Selumetinib_30min_R2 2 LEGEVTPNSLSTSYK 15 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 LEGEVT(0.977)PNS(0.022)LSTSYK;LEGEVT(0.939)PNS(0.049)LS(0.011)T(0.001)SYK 114.27 0.0060016 3377100.0 34429.0 34368.0 40663.0 42116.0 36812.0 31136.0 38085.0 33853.0 27740.0 34189.0 True False 32515.574010206954 37003.91508946249 38046.786850526885 36379.72814584762 32187.347456544518 35424.70137553331 39856.0279639958 33951.50662533415 33288.77512035987 33201.87473631003 0.9793294586057659 1.1145128214400044 1.1459228478119157 1.0957130714688905 0.9694436748580342 1.0669488291512759 1.2004149850131416 1.022577998832226 1.0026173336517894 1.0 15.018977084869139 -7.978394171152277 24.99908115084157 1.0050715401157742 1.0832996926931306 0.21246526807001098 0.06545082076797284 356.3843210139961 412355.03265964997 0.0371571051151531 0.01784693620973009 1.0510075331028488e-08 7.978394171152277 0.07822815257735649 LEGEVTPNS(ph)LSTSYK ddPTM_A459_Selumetinib_30min_R1 1 LEGEVTPNSLSTSYK 15 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 LEGEVT(0.424)PNS(0.574)LS(0.001)T(0.001)SYK 127.3 0.0010687 5888000.0 2466.5 2466.5 2944.8 2839.8 2830.1 2268.2 2598.4 2567.9 1350.4 1963.5 True False 2523.9646510264574 2177.7210333552575 2544.912334628534 2343.8822396481096 2574.117954694737 2245.3839673608236 2402.40059601616 2499.7909502852485 2291.530170686303 2215.5343511096244 1.1392126011327062 0.9829326420800344 1.1486675137101552 1.0579308953048747 1.161849715128777 1.0134728744947012 1.0843436459529259 1.1283015986790084 1.034301350163502 1.0 11.113438980157266 -9.984209499824868 10.173393303978626 1.000005372990926 1.0832510998614862 0.15722973047973354 0.057956418745548695 0.0 0.0 0.05156995124997214 0.012507550359505216 1.0370280419654012e-10 9.984209499824868 0.0832457268705602 LEGGRQDS(ph)EDEEER ddPTM_A459_Selumetinib_30min_R1 1 LEGGRQDSEDEEER 14 1 A0A3B3ISZ4;Q9BYE7-3;Q9BYE7 A0A3B3ISZ4 PCGF6 Polycomb group RING finger protein 6 1 LEGGRQDS(1)EDEEER 174.47 0.00040454 6996700.0 2148.4 2846.7 2256.7 2298.4 2471.3 2150.7 2406.4 2295.7 1487.9 2157.6 True False 2198.453539941312 2513.407040605073 1950.2525351657873 1897.0275863114348 2247.7713513434514 2129.0659106793582 2224.8833105962462 2234.8105785154603 2524.857628083642 2434.5489768037287 0.9030229257608193 1.0323912414795102 0.8010734447109934 0.7792111000379236 0.9232803992690696 0.8745217003087639 0.9138790518469058 0.9179567138753968 1.0370946126532552 1.0 11.249438808839109 -8.12632776433477 3.0623886732123773 1.0191626292020264 0.8887836728903835 0.3695963892131011 0.0659939931539125 0.30786629262301135 5.160283222011063 0.05754504543520063 0.018619129400279703 7.476050660629435e-09 8.12632776433477 -0.13037895631164287 LEGPVS(ph)PDVEPGKEETEESK ddPTM_A459_Selumetinib_30min_R1 4 LEGPVSPDVEPGKEETEESK 20 1 O14686;O14686-3;A0A3B3ISC8 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LEGPVS(1)PDVEPGKEETEESK;LEGPVS(1)PDVEPGKEETEESK;LEGPVS(1)PDVEPGKEETEESK;LEGPVS(1)PDVEPGKEETEESK 122.34 0.00013345 152120500.0 18540.5 20128.6 19665.1 18762.3 16050.8 17881.9 18548.5 20525.2 11953.9 18638.0 True False 18972.45757646709 17771.93415446774 16994.687432662166 15485.816516990531 14599.007973998905 17702.02432146614 17149.37171151697 19980.80502075424 20284.895221687664 21030.368849493854 0.9021457356380941 0.8450605066251828 0.8081022046872556 0.7363549649469526 0.6941869673555566 0.8417362742495208 0.8154574859931528 0.950092942437152 0.9645525176880513 1.0 14.360186533122187 -7.795093206398724 2.3264308262185254 0.9829121223017225 0.798713346420528 0.6551378498766285 0.05517067103596724 0.20736316922231304 2.217433161626153 0.041868684053960104 0.017428235187187717 1.60290134603553e-08 7.795093206398724 -0.1841987758811945 LEGPVS(ph)PDVEPGKEETEESK ddPTM_A459_Selumetinib_30min_R2 4 LEGPVSPDVEPGKEETEESK 20 1 O14686;O14686-3;A0A3B3ISC8 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LEGPVS(1)PDVEPGKEETEESK;LEGPVS(1)PDVEPGKEETEESK;LEGPVS(1)PDVEPGKEETEESK;LEGPVS(1)PDVEPGKEETEESK 98.169 0.00049139 148713000.0 403711.0 373876.0 376530.0 361241.0 310086.0 274979.0 342400.0 351600.0 230901.0 334771.0 True False 381274.35880317935 402551.0869991824 352304.46973486623 312039.3526245168 271130.22447598766 312854.86123916885 358322.2784527282 352623.0977894868 277087.6519129854 325105.29139048303 1.1727719262041534 1.2382175795338854 1.083662675030762 0.9598101319419229 0.8339766581969714 0.9623185765481737 1.1021730126882134 1.0846427515261579 0.8523012674689944 1.0 18.31054751185753 -5.515017034315383 3.321606027110882 0.9743306252169082 1.2032522904492184 0.5695760939814223 0.08173551401017144 0.18637347716148697 4.2614024816169 0.02453815993263108 0.05166321087941914 3.054801292514717e-06 5.515017034315383 0.22892166523231028 LEGPVS(ph)PDVEPGKEETEESKK ddPTM_A459_Selumetinib_30min_R2 2 LEGPVSPDVEPGKEETEESKK 21 2 O14686;O14686-3;A0A3B3ISC8 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LEGPVS(0.99)PDVEPGKEET(0.004)EES(0.006)KK;LEGPVS(1)PDVEPGKEETEESKK 92.671 0.00064715 11386700.0 64142.0 58116.0 53907.0 52071.0 44798.0 36594.0 47854.0 52321.0 37535.0 52376.0 True False 60577.244420770156 62573.31032760715 50438.68230950382 44978.83997251477 39170.07474079867 41634.49133274236 50079.30582090207 52473.24544779218 45043.04881552663 50863.76879080915 1.1909704267080616 1.230213800808914 0.9916426467914006 0.8843001814808942 0.7700977664847464 0.8185490836114669 0.9845771756879953 1.0316428903175152 0.8855625504428941 1.0 15.634350743157652 -5.383595404297686 3.304786058197757 0.9064831856963479 1.213292139087612 0.7002855330223071 0.07713690823336407 0.14383056309650782 2.894270643997746 0.023380314568209822 0.055765722590024935 4.134324829647194e-06 5.383595404297686 0.306808953391264 LEGVDGGQS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 LEGVDGGQSPR 11 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 LEGVDGGQS(1)PR;LEGVDGGQS(1)PR 169.58 0.00041306 111565000.0 6947.7 8743.3 8555.2 9731.5 8825.5 7402.3 8495.7 7251.1 4236.2 6434.4 True False 7109.567892129138 7719.630371350106 7393.450830349777 8032.076207879281 8027.235083268579 7327.839582750646 7854.862509072694 7058.777273107744 7188.522000193513 7260.317916363517 0.9792364430909267 1.0632634080597734 1.0183370639577918 1.1062981401649579 1.1056313477921624 1.0093000977594861 1.0818896086312109 0.9722407963979739 0.9901111883808575 1.0 12.825817007307224 -7.769047905457606 24.999999521058097 0.9858819777612838 1.053642246621034 0.35981000405289054 0.039393131457510465 190.52537730639435 626013.5398283353 0.021152277192922557 0.01046498078933121 1.701970759785455e-08 7.769047905457606 0.06776026885975017 LEGVDGGQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 LEGVDGGQSPR 11 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 LEGVDGGQS(1)PR;LEGVDGGQS(1)PR;LEGVDGGQS(1)PR 131.08 0.0022707 98477000.0 164493.0 170452.0 200969.0 211500.0 211625.0 145250.0 150653.0 173561.0 157146.0 185629.0 True False 155351.13757765168 183525.12031043583 188038.87333850318 182693.33514214942 185038.77554849588 165256.86905177945 157658.663013256 174066.03377542985 188579.59102610202 180269.40844793653 0.8617720494851379 1.0180602570925925 1.0430991866976174 1.0134461344000745 1.0264568855116467 0.9167216471978781 0.8745724766650538 0.9655883118166537 1.0460986844618483 1.0 17.459795067962382 -6.755306625060361 24.999537511044775 0.9530690090972592 0.9979505030089197 0.04985709248899217 0.06366845341575206 379.06299013048 1545209.1509468593 0.022157622872951286 0.021634223158680483 1.756682904674946e-07 6.755306625060361 0.04488149391166052 LEIS(ph)PHR ddPTM_A459_Selumetinib_30min_R2 2 LEISPHR 7 0 Q96QB1-6;Q96QB1-4;Q96QB1-1;Q96QB1 Q96QB1-6 DLC1 Rho GTPase-activating protein 7 1 LEIS(1)PHR;LEIS(1)PHR 85.86200000000002 0.02744 1590900.0 23252.0 25951.0 24998.0 32854.0 30626.0 24683.0 22143.7 22418.0 20903.0 26209.0 True False 21959.746925130923 27941.358254383176 23389.655895764477 28379.228523688816 26778.48808008617 28082.85920003496 23173.425926909138 22483.232668500303 25084.184078618688 25452.27807084 0.8627811964025972 1.0977940040029206 0.918961195955241 1.1149975827194087 1.0521057488667616 1.1033534649383212 0.9104656904349289 0.8833485398015806 0.9855378763662406 1.0 14.635507168047658 -10.111792672419407 5.4921597277480325 1.0000000000684928 0.9961488860343588 0.0 0.09110638656469655 6.58755333841259e-11 1.2036991793582882e-18 0.08940507561089017 0.02168391541003456 7.730495426750735e-11 10.111792672419407 -0.0038511140341339622 LEKPETQSS(ph)PITVQSSK ddPTM_A459_Selumetinib_30min_R1 2 LEKPETQSSPITVQSSK 17 1 Q96CB8;A0A087WXN4;E9PGI3 Q96CB8 INTS12 Integrator complex subunit 12 1 LEKPETQS(0.176)S(0.765)PIT(0.041)VQS(0.014)S(0.003)K;LEKPETQS(0.009)S(0.988)PIT(0.003)VQSSK 131.3 0.00043706 72066000.0 8063.099999999999 9108.099999999999 10961.099999999999 10270.5 9168.8 8665.1 8882.6 8282.3 4654.3 8289.6 True False 8250.954541938549 8041.719417759183 9472.642825012503 8476.94997616237 8339.483658883117 8577.93696128131 8212.578330577715 8062.626499298069 7898.00716337771 9353.65090754181 0.882110592270002 0.8597412387151606 1.0127214409268523 0.9062717926887179 0.8915752513448011 0.9170683240236124 0.8780077866660543 0.86197641744329 0.8443769434467111 1.0 13.191313870853588 -7.25866280210652 24.362271278839277 0.8845883212950372 0.9126716207925389 0.0013306683050254842 0.05453652565325816 594.0086369791095 5212007.544595829 0.021272570024800118 0.015729016684702925 5.512355243532361e-08 7.25866280210652 0.028083299497501768 LEKVPDS(ph)PENELK ddPTM_A459_Selumetinib_30min_R2 2 LEKVPDSPENELK 13 1 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35 A0A0U1RR46 INADL InaD-like protein 1 LEKVPDS(1)PENELK;LEKVPDS(1)PENELK 98.572 0.0068449 19423000.0 173412.0 157105.0 141455.0 142043.0 125676.0 106301.0 127085.0 129282.0 84841.0 129398.0 True False 163774.4552632379 169154.44832780538 132353.93930455876 122696.49836215754 109887.4573223048 120942.9978455988 132994.70431415006 129658.18921621288 101811.57065560372 125661.94352362004 1.3032939859986652 1.3461072110189851 1.0532539573501094 0.9764014061989651 0.8744688665558464 0.9624472967256452 1.0583530748046381 1.0318015588533507 0.8102021009763128 1.0 16.939188272940847 -5.372670603339743 3.0556187723373722 0.9626105116878325 1.3307589971256992 0.8089503059115859 0.06985895331331822 0.1059395647492049 1.8627259275488643 0.01963988445020032 0.04893605772219942 4.2396440580499245e-06 5.372670603339743 0.3681484854378667 LELCSDDQGSLS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 1 LELCSDDQGSLSPAR 15 0 H3BRS1;Q12968;I3L3K7;H3BR83;Q12968-5;Q12968-6;Q12968-4;Q12968-3;Q12968-2 H3BRS1 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 1 LELCSDDQGSLS(1)PAR 130.64 0.00077953 4007600.0 1043.2 1109.4 561.75 722.6 868.51 946.31 1073.7 1065.7 582.02 833.29 True False 1067.5045302861554 979.5109322539327 485.46743547187555 596.4114748819367 789.9534238478942 936.7909805807333 992.7099445591707 1037.4341741185362 987.6454309410856 940.2508884319519 1.1353400921177785 1.041754859585886 0.5163169122674112 0.6343109931824332 0.8401517441427708 0.9963202291071602 1.055792615324942 1.103358887380214 1.0504062725090035 1.0 9.876901954226444 -6.830551689928708 3.3376870433872754 1.0571315873481364 0.814520836905216 0.27855552627832614 0.16782945983874786 0.3428630731265333 7.677746275590484 0.06927662557401489 0.062013352214693555 1.4772306504555603e-07 6.830551689928708 -0.24261075044292035 LELDGEKETAPEEPGS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 LELDGEKETAPEEPGSPAK 19 1 P35612 P35612 ADD2 Beta-adducin 1 LELDGEKETAPEEPGS(1)PAK 77.575 0.0044109 12068000.0 4664.5 3875.9 4000.1 4297.7 3102.6 3296.5 3234.4 3079.9 2322.5 3386.1 True False 4773.173774462974 3422.107826142974 3456.908390976497 3547.1873728205073 2821.970377808518 3263.340202982519 2990.426603969621 2998.2110470748617 3941.1128713114185 3820.738918407078 1.2492802770342077 0.8956664925876957 0.9047748262311869 0.9284034969600544 0.738592831929233 0.854112325566347 0.7826827919496717 0.7847202101746485 1.0315054117737326 1.0 11.8996359624077 LELDGEKETAPEEPGS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 LELDGEKETAPEEPGSPAK 19 1 P35612 P35612 ADD2 Beta-adducin 1 LELDGEKETAPEEPGS(1)PAK;LELDGEKETAPEEPGS(1)PAK 90.06 0.0015267999999999998 11242700.0 77434.0 60452.0 66378.0 73753.0 61224.0 50493.0 65337.0 70471.0 44154.0 53000.0 True False 73130.52827286196 65088.4740161833 62107.311746901905 63707.71416897862 53532.493770495515 57447.9524201825 68375.29996280948 70676.05894289794 52986.03376583889 51469.7522894624 1.4208447684298309 1.2645966052086308 1.2066759404167051 1.2377699781940033 1.0400767710991186 1.1161497746695788 1.3284559750408635 1.373157161227833 1.0294596614308347 1.0 15.651437218794419 -1.5228788194640572 0.022461639610276127 3.865149247714064e-07 2.8018305819323492 0.31604934899942794 0.11770386077244153 3879.4829611465816 6.73340268895283 300.28385961508667 582.5813003657988 0.029999994875570625 1.5228788194640572 2.8018301954174243 LELKAS(ph)PNVEAPQPHR ddPTM_A459_Selumetinib_30min_R2 2 LELKASPNVEAPQPHR 16 1 A0A494C0R9;E9PEM5;A0A494C1L5;P50851-2;P50851;A0A494BZW2 A0A494C0R9 LRBA Lipopolysaccharide-responsive and beige-like anchor protein 1 LELKAS(1)PNVEAPQPHR;LELKAS(1)PNVEAPQPHR 67.102 0.021985 8995400.0 82214.0 75137.0 78553.0 75391.0 73736.0 58428.0 56117.0 61658.0 51795.0 68111.0 True False 77644.87500871808 80899.76629646584 73498.98550203962 65122.6157432709 64472.62447179624 66475.92664342432 58726.551693725945 61837.414571968606 62155.44727321704 66144.45845636945 1.1738681791451144 1.223077007272338 1.1111888617324066 0.9845513481107026 0.9747245041596947 1.0050112767537966 0.8878529368029138 0.9348842822979361 0.9396924356742045 1.0 16.01333267297852 -5.658999586240622 2.0360978051709377 0.9524164280803112 1.2018689746609166 0.8908223008807293 0.03436970531065163 0.09641412477025615 0.806922281072205 0.010617510911498552 0.023170249908200477 2.1928070244721765e-06 5.658999586240622 0.24945254658060534 LELSSSAS(ph)PQEER ddPTM_A459_Selumetinib_30min_R1 3 LELSSSASPQEER 13 0 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 LELSSS(0.004)AS(0.995)PQEER;LELSS(0.001)S(0.005)AS(0.994)PQEER;LELSSS(0.007)AS(0.993)PQEER 214.58 1.748e-06 51441000.0 5668.2 6315.0 6766.1 6499.0 6388.200000000001 5793.9 5808.200000000001 5363.9400000000005 3404.92 4817.0 True False 5800.258031602747 5575.6368642361485 5847.300783526932 5364.0716513392035 5810.388437928317 5735.618626440295 5370.082797791351 5221.670886667337 5777.900554482531 5435.308871553379 1.067144143722796 1.0258178506500708 1.0757991719899826 0.9868936206023162 1.0690079580091543 1.0552516447517157 0.9879995644583514 0.9606944168335764 1.0630307662407494 1.0 12.408146306077846 -7.2601182199412255 24.97930304611558 0.9996557207332101 1.0453300811670043 0.2822733004721789 0.03395469016290553 148.24607709420786 2802905.2381674214 0.012973800509176365 0.009513635235881694 5.4939130288452155e-08 7.2601182199412255 0.04567436043379425 LELSSSAS(ph)PQEER ddPTM_A459_Selumetinib_30min_R2 4 LELSSSASPQEER 13 0 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 LELSSS(0.001)AS(0.999)PQEER;LELSSS(0.005)AS(0.995)PQEER;LELSS(0.001)S(0.029)AS(0.971)PQEER;LELS(0.008)S(0.03)S(0.017)AS(0.945)PQEER 227.91 6.0208e-13 60538000.0 123920.0 127822.0 140915.0 158073.0 161608.0 108058.0 116217.0 117107.0 116715.0 141727.0 True False 117033.02249106429 137625.5363874906 131848.6823166516 136543.18470886553 141305.35824614915 122942.00864714089 121621.32077961668 117447.76198189255 140061.261289575 137634.97325903105 0.8503145655487316 0.9999314355115057 0.9579591523479315 0.9920675063589343 1.0266675315162113 0.8932468669555537 0.8836512835347711 0.8533278947993409 1.0176284266497995 1.0 17.070487582095886 -6.78953094332871 24.999145917432593 0.9175339139175711 0.9683766591624672 0.05525965651402753 0.06456148709998348 463.9298643926628 412855.35197394533 0.022349937284320626 0.01971444790357635 1.6235626680936657e-07 6.78953094332871 0.05084274524489607 LENEGS(ph)DEDIETDVLYSPQMALK ddPTM_A459_Selumetinib_30min_R1 4 LENEGSDEDIETDVLYSPQMALK 23 0 O60502-3;O60502 O60502-3 MGEA5 Protein O-GlcNAcase 1 LENEGS(1)DEDIETDVLYSPQMALK;LENEGS(1)DEDIETDVLYSPQMALK;LENEGS(1)DEDIETDVLYSPQMALK;LENEGS(0.99)DEDIET(0.008)DVLY(0.001)SPQMALK 218.6 1.0772e-26 15746300.0 6811.43 8026.210000000001 8434.53 8670.79 7917.08 7396.52 7071.530000000001 7069.85 4051.5200000000004 6366.99 True False 6970.1230662644 7086.497601916205 7289.167153556913 7156.59929738659 7200.9815118740025 7322.117724302823 6538.118798778533 6882.334611890715 6875.133528687037 7184.255186234508 0.9701942491713826 0.9863928017888879 1.014603040204282 0.9961504862882782 1.0023281920262999 1.0191895380237146 0.910062160835543 0.9579746867953282 0.9569723444484868 1.0 12.810622880478405 -7.243252091964248 24.998348615131466 0.9527501830896193 0.998456792690285 0.4196762586287738 0.023989794835114365 721.5472747336536 991765.1150824496 0.008968628324451007 0.006933751037517543 5.711470106119715e-08 7.243252091964248 0.04570660960066564 LENEGS(ph)DEDIETDVLYSPQMALK ddPTM_A459_Selumetinib_30min_R2 3 LENEGSDEDIETDVLYSPQMALK 23 0 O60502-3;O60502 O60502-3 MGEA5 Protein O-GlcNAcase 1 LENEGS(1)DEDIETDVLYSPQMALK;LENEGS(1)DEDIETDVLYSPQMALK;LENEGS(1)DEDIETDVLYSPQMALK 143.39 3.2074e-08 1212300.0 17049.4 19536.4 20582.6 19058.5 23836.8 18598.600000000002 13148.5 14870.7 13022.5 20466.5 True False 16101.862602155816 21034.779060573077 19258.337924640447 16462.69942225371 20842.208080304245 21160.388328718956 13759.931303258474 14913.971275023096 15627.363879051416 19875.57896664684 0.8101330094170495 1.0583228340604058 0.9689447515947996 0.8282877922640505 1.0486340103742136 1.0646426131398814 0.6923034205116229 0.7503666333468924 0.7862595552700958 1.0 14.278709265614093 -7.262412152419839 24.999986206697983 0.7864296224396728 0.9655038368814197 0.3131712762608291 0.11140345689341845 95.63626096282766 2457778.309017574 0.04378220710044364 0.03144322881430227 5.4649708223507586e-08 7.262412152419839 0.17907421444174687 LENS(ph)PLGEALR ddPTM_A459_Selumetinib_30min_R2 2 LENSPLGEALR 11 0 D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;D6RDK6;D6RBN5;Q9NX40-3;Q9NX40-2;Q9NX40-4;Q9NX40 D6RI08 OCIAD1 OCIA domain-containing protein 1 1 LENS(1)PLGEALR;LENS(1)PLGEALR 140.27 0.0010997 21874900.0 118319.0 87220.0 100673.0 130236.0 120366.0 91437.0 125328.0 116904.0 92470.0 100532.0 True False 111743.3036484846 93909.49354349736 94195.80878447476 112497.63213036892 105244.54699430706 104031.61676755655 131156.00033272058 117244.171285501 110966.58382767416 97629.3799464949 1.1445663560469679 0.9618978794596852 0.9648305544509053 1.1522928056290276 1.0780007724312661 1.0655769485022886 1.3434070809893468 1.2009107437715558 1.1366105560486877 1.0 16.575027747877996 -7.045165286005855 24.993076855568674 1.1894771939638964 1.0563681200410115 0.2172481828843562 0.09862749245394742 566.693434200567 313588.8981636543 0.03733940052226955 0.028924395099997384 9.012280783563172e-08 7.045165286005855 -0.13310907392288485 LENSALLTVEPS(ph)PQDKNK ddPTM_A459_Selumetinib_30min_R2 1 LENSALLTVEPSPQDKNK 18 1 O75509 O75509 TNFRSF21 Tumor necrosis factor receptor superfamily member 21 1 LENSALLTVEPS(1)PQDKNK 138.04 0.00058589 0.0 22495.0 12784.0 14808.0 18946.0 16868.0 11366.0 16867.0 16103.0 11790.0 15910.0 True False 21244.817954619833 13764.49169296114 13855.269401731353 16365.522116327033 14748.891038166692 12931.563329724795 17651.348921326444 16149.85706400484 14148.329440124124 15450.63696085561 1.3750124353089037 0.8908688831297803 0.8967442207615037 1.0592134264619184 0.954581424412029 0.8369598847275409 1.1424350313871439 1.045255098862313 0.9157117260582266 1.0 13.915378694787544 -4.7541565132484145 24.999990388642935 0.9737655630603893 1.3750131375720789 0.6562374960783048 0.08764016963800737 165.7337713350264 568868.3578033478 0.0223732574129974 0.22476935058676248 1.761341170952817e-05 4.7541565132484145 0.4012475745116896 LENT(ph)SPMVK ddPTM_A459_Selumetinib_30min_R1 1 LENTSPMVK 9 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 LENT(0.719)S(0.281)PMVK 115.0 0.01031 0.0 2983.1 3456.7 3559.8 3820.7 3454.8 2762.5 2858.7 3002.4 1864.0 2843.0 True False 3052.6004258978423 3051.9879570237667 3076.3987125817225 3153.4864684215527 3142.3139499944796 2734.711758149315 2643.065957447426 2922.7665988303406 3163.071858826473 3207.926743165093 0.9515804662315954 0.9513895426466411 0.9589990541823912 0.9830294520099213 0.9795466672328444 0.8524857258589136 0.8239171804901168 0.9111076507771497 0.9860174848337204 1.0 11.647425481168396 -6.7378285430952785 24.999782444254187 0.9034755377685666 0.9648363244347373 0.17872751909239848 0.05104496842426401 346.6595898617206 367051.75368903845 0.017485742208805267 0.01747607705090532 1.828822081830658e-07 6.7378285430952785 0.06136078666617073 LENT(ph)SPMVK ddPTM_A459_Selumetinib_30min_R2 1 LENTSPMVK 9 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 LENT(0.5)S(0.5)PMVK 110.84 0.024836 6318900.0 75887.0 81942.0 85898.0 82949.0 85746.0 57145.0 72913.0 72688.0 59709.0 85929.0 True False 71669.50433973043 88226.68791494214 80371.41619867091 71651.20310499384 74973.82090103395 65016.20503933872 76303.59897436864 72899.5100458539 71652.46840885252 83448.00649964566 0.8588522044566127 1.0572653753606058 0.9631316501133215 0.8586328914316016 0.8984495142056186 0.7791223273813592 0.9143849227206241 0.873591989835772 0.8586480542127364 1.0 16.34858996481824 -5.742318434449141 11.696717816438218 0.8755850190335869 0.9695631919842134 0.19646705192062175 0.06883342904053905 0.7574633709767344 455.6785522134903 0.017665971587675904 0.03003589813030377 1.8100124642441828e-06 5.742318434449141 0.09397817295062649 LENT(ph)TPTQPLTPLHVVTQNGAEASSVK ddPTM_A459_Selumetinib_30min_R2 1 LENTTPTQPLTPLHVVTQNGAEASSVK 27 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 LENT(0.469)T(0.361)PT(0.132)QPLT(0.037)PLHVVTQNGAEASSVK 98.94 2.1871e-06 3879400.0 17577.0 13828.0 16459.0 20029.0 18438.0 12592.0 10148.0 12525.0 12883.0 16745.0 True False 16600.14070630597 14888.563135972056 15400.045859204243 17301.01564804783 16121.653602188613 14326.433701204887 10619.902107880514 12561.44567637463 15459.959981095759 16261.52834126506 1.0208229114714666 0.9155697314249986 0.9470232770265062 1.0639231002749587 0.991398426018697 0.8810016746611878 0.6530691264074839 0.772464027535398 0.9507076860583116 1.0 13.989175235163211 -6.898155968260573 4.49278183791915 0.8181131198899215 0.9850303400236539 0.31941284228946065 0.09712608410154842 0.22790649398590543 8.036387280148361 0.035479086784563296 0.0311156631988194 1.2642822240137412e-07 6.898155968260573 0.16691722013373234 LENTTPT(ph)QPLTPLHVVTQNGAEASSVK ddPTM_A459_Selumetinib_30min_R1 1 LENTTPTQPLTPLHVVTQNGAEASSVK 27 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 LENT(0.005)T(0.004)PT(0.564)QPLT(0.427)PLHVVTQNGAEASSVK 90.974 3.4367e-05 8847500.0 1025.7 1360.7 1355.5 1334.5 1112.5 1006.4 1113.8 1402.5 709.87 1186.1 True False 1049.5968143352281 1201.3886114277323 1171.4305452285305 1101.454626667513 1011.8745714278274 996.2765297380882 1029.7851692744757 1365.3011440379541 1204.5975431465392 1338.3474885923733 0.7842483534968613 0.897665682244684 0.8752813116275204 0.8229959977180396 0.756062666872922 0.7444079644711231 0.7694452883515084 1.0201395046318873 0.9000633642713317 1.0 10.386237030672827 -7.759268904612221 24.99975730242593 0.97007609052495 0.8094898162858871 0.6595555229447 0.05469947294537957 38.709725539428575 445880.42198324733 0.02992412930514859 0.0161899627000516 1.7407287226285977e-08 7.759268904612221 -0.1605862742390629 LENTTPTQPLT(ph)PLHVVTQNGAEASSVK ddPTM_A459_Selumetinib_30min_R2 2 LENTTPTQPLTPLHVVTQNGAEASSVK 27 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 LENT(0.001)T(0.002)PT(0.046)QPLT(0.951)PLHVVTQNGAEASSVK;LENTTPT(0.006)QPLT(0.993)PLHVVT(0.001)QNGAEASSVK 118.04 1.1162e-11 10619300.0 24673.0 26813.0 26693.0 33710.0 31615.0 25834.0 26221.0 24400.0 24031.0 30547.0 True False 23301.773433844628 28869.470882616337 24975.60144114096 29118.639847006434 27643.241058313994 29392.399002297258 27440.328455925795 24470.999960362537 28837.871482241117 29665.02873936241 0.7854964051636194 0.9731819623794785 0.8419206891918811 0.9815813799758443 0.9318460906000838 0.9908097261775648 0.925005962307238 0.8249107113755149 0.9721167552410377 1.0 14.856475560025276 -4.751359445697109 24.990058827114122 0.931881074335271 0.7854961052619012 0.3806511511857833 0.05787086747653988 458.2389998149606 1135983.7559715516 0.013973150333851962 0.1862629673952207 1.772721672832981e-05 4.751359445697109 -0.14638496907336984 LENVSQLSLDKS(ph)PTEK ddPTM_A459_Selumetinib_30min_R2 3 LENVSQLSLDKSPTEK 16 1 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 LENVS(0.002)QLS(0.012)LDKS(0.506)PT(0.48)EK;LENVS(0.003)QLS(0.104)LDKS(0.696)PT(0.197)EK;LENVS(0.006)QLS(0.067)LDKS(0.811)PT(0.115)EK 130.77 0.0036015 155849600.0 259527.0 227270.0 235352.0 233198.0 211909.0 168067.0 212606.0 211685.0 150553.0 204541.0 True False 245103.52830889614 244700.87821177093 220209.70855188218 201436.0301110115 185287.09692950352 191216.70368967613 222492.6002707968 212300.96830366197 180667.806802291 198635.3698686587 1.2339369794561919 1.23190989788763 1.1086127747414212 1.0140995042534704 0.9328001204016118 0.9626518369619272 1.1201056509619256 1.0687974072494704 0.9095449965519827 1.0 17.599763012664198 -5.47981727900478 2.340357835508638 1.0040224646133804 1.2377717067385037 0.719169920445033 0.05801014355788618 0.17394995432617938 1.8584957262853803 0.017872881660560745 0.044847721445195936 3.3127046780275822e-06 5.47981727900478 0.23374924212512327 LENVSQLSLDKSPT(ph)EK ddPTM_A459_Selumetinib_30min_R1 1 LENVSQLSLDKSPTEK 16 1 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 LENVS(0.01)QLS(0.004)LDKS(0.402)PT(0.584)EK 85.988 0.02197 166250000.0 6562.1 8116.9 7706.3 7321.3 6068.0 6218.2 6485.8 6405.0 4071.1 6560.4 True False 6714.98416237613 7166.56957455556 6659.826787675855 6042.772392821926 5519.1504713924105 6155.6505536738705 5996.570884252461 6235.118593627873 6908.359358620415 7402.491243707452 0.9071249044818874 0.968129422732862 0.8996737136753921 0.8163160473791352 0.7455801418318474 0.8315647193647857 0.8100747014526893 0.8423000295918063 0.933247893334953 1.0 12.853795163524246 -5.571377595949444 4.78374197354166 0.8406708974462836 0.9373184188898794 0.17925497192458695 0.06821423602574572 0.2558544472314952 12.765504490704222 0.018424107150348156 0.033648528372944075 2.6830106961941347e-06 5.571377595949444 0.09664752144359579 LEPAS(ph)PPEDTSAEVSR ddPTM_A459_Selumetinib_30min_R1 1 LEPASPPEDTSAEVSR 16 0 E9PFE2;Q9UHL9-2;Q9UHL9;Q9UHL9-3 E9PFE2 GTF2IRD1 General transcription factor II-I repeat domain-containing protein 1 1 LEPAS(0.952)PPEDT(0.024)S(0.024)AEVSR 129.05 0.00090233 9509600.0 1732.9 1957.6 1356.0 1390.5 1405.1 1208.2 1719.3 1814.8 593.9 1045.4 True False 1773.2731983635729 1728.40328193645 1171.8626479748336 1147.6752779177039 1278.008953090554 1196.0466049578288 1589.6118167836296 1766.6656086988087 1007.8049232602165 1179.5872730583144 1.5032997039430662 1.4652610463109024 0.9934514170677231 0.972946473847694 1.0834373871948126 1.0139534668400079 1.347600006451617 1.4976980924170002 0.8543708009389436 1.0 10.204066446563399 -5.2453910784816475 21.572457963350377 1.1145003349627904 1.4842811076004527 0.42120454391576145 0.18122971211284822 141.99663907855415 190868.13472659106 0.04857768899896238 0.12709180542192272 5.683409141930027e-06 5.2453910784816475 0.3697807726376623 LEPAS(ph)PPEDTSAEVSR ddPTM_A459_Selumetinib_30min_R2 2 LEPASPPEDTSAEVSR 16 0 E9PFE2;Q9UHL9-2;Q9UHL9;Q9UHL9-3 E9PFE2 GTF2IRD1 General transcription factor II-I repeat domain-containing protein 1 1 LEPAS(0.959)PPEDT(0.02)S(0.02)AEVSR;LEPAS(1)PPEDTSAEVSR 141.06 0.00039792 21081700.0 36700.0 30822.0 39285.0 39812.0 43736.0 34871.0 35480.0 38324.0 36132.0 33268.0 True False 34660.360921740255 33185.94829164959 36757.44587027393 34389.536920469334 38241.49267519912 39674.163722579055 37129.89030228622 38435.51649512024 43359.409612431235 32307.466399355406 1.0728281968415758 1.0271912963225032 1.1377384229364178 1.0644454905679472 1.1836735261902838 1.2280184163054837 1.14926654548891 1.18967906737147 1.3420863486000973 1.0 14.97957999624974 -6.287013161447043 6.862384083334857 1.1925813137053298 1.0764535326766742 0.2783300578588155 0.08305958963097575 0.23221301616492823 44.4610147545061 0.024561868863497305 0.028535380080918944 5.164007193294832e-07 6.287013161447043 -0.11612778102865562 LEPASPPEDTS(ph)AEVSR ddPTM_A459_Selumetinib_30min_R1 1 LEPASPPEDTSAEVSR 16 0 E9PFE2;Q9UHL9-2;Q9UHL9;Q9UHL9-3 E9PFE2 GTF2IRD1 General transcription factor II-I repeat domain-containing protein 1 1 LEPAS(0.321)PPEDT(0.005)S(0.674)AEVSR 176.42 1.2111e-06 9299600.0 4757.6 5125.0 4010.4 4587.6 4759.6 3964.3 5955.3 5362.1 2472.1 4268.6 True False 4868.442823321906 4524.962617452139 3465.8097075503492 3786.461779917485 4329.095020375632 3924.422741296408 5506.08692636046 5219.8796894444995 4194.973144959725 4816.516389685022 1.0107809108151462 0.9394679165096853 0.7195677180654206 0.7861411596203667 0.8988020947352647 0.8147844674007322 1.1431678999685773 1.0837458584431092 0.8709558538913343 1.0 12.233774359670859 -7.24675827960374 24.96973796824192 1.0314462294768385 0.8569368902862473 0.3881429061163475 0.09992708539842643 824.0803906093697 1401604.5006913992 0.040254122817504394 0.03103972431874697 5.665545352322815e-08 7.24675827960374 -0.1745093391905912 LEPGS(ph)DVEVK ddPTM_A459_Selumetinib_30min_R1 2 LEPGSDVEVK 10 0 Q9ULI0-2;Q9ULI0;H7BYF1 Q9ULI0-2 ATAD2B ATPase family AAA domain-containing protein 2B 1 LEPGS(1)DVEVK;LEPGS(1)DVEVK 158.01 0.00048252 23689000.0 9156.8 12973.2 5271.4 5003.1 6597.2 6890.700000000001 10687.8 10989.6 6395.2 12118.5 True False 9370.135623968808 11454.291712922944 4555.572833727534 4129.4025048184585 6000.4844248302625 6821.385814255017 9881.610641202851 10698.120108748304 10852.187313072454 13674.027519186142 0.6852506045363367 0.8376677388466077 0.33315516056520816 0.3019887519623944 0.4388234860878357 0.4988571073653226 0.7226554595811571 0.7823678937121987 0.7936350353138941 1.0 13.739150613434854 -7.687573989200694 1.3800337848686468 0.8994553473861076 0.5083629372973516 0.5024889565087286 0.15616972764037362 0.43000984865011105 1.5284148842644831 0.13888248226903602 0.056872446533585294 2.0531752045281235e-08 7.687573989200694 -0.39109241008875595 LEPGS(ph)DVEVK ddPTM_A459_Selumetinib_30min_R2 4 LEPGSDVEVK 10 0 Q9ULI0-2;Q9ULI0;H7BYF1 Q9ULI0-2 ATAD2B ATPase family AAA domain-containing protein 2B 1 LEPGS(1)DVEVK;LEPGS(1)DVEVK;LEPGS(1)DVEVK;LEPGS(1)DVEVK 177.83 8.7401e-05 34579200.0 259757.0 165692.0 215138.0 258405.0 237953.0 235313.0 327405.0 331310.0 275136.0 180117.0 True False 245320.7458296589 178400.04361624803 201296.25530454394 223209.79322651197 208059.21681318936 267725.22979126597 342629.98124070006 332274.0572486766 330170.88794215315 174916.55420983172 1.4025015924757447 1.0199151499533743 1.1508130617703962 1.2760930160946755 1.1894769923468727 1.5305882910893613 1.958819637103516 1.8996146977036672 1.887590854014176 1.0 17.416307307700144 -6.919542088377887 3.5001326164905864 1.761796805552752 1.1975273803197204 0.39990939040157125 0.27201115195768694 0.1984356479422361 4.839278224563523 0.09686535250606564 0.08332291864500527 1.2035327472876008e-07 6.919542088377887 -0.5642694252330316 LEPKEES(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 LEPKEESPTR 10 1 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 LEPKEES(0.987)PT(0.013)R 114.76 0.032551 6466700.0 30983.0 41222.0 35512.0 39429.0 44160.0 29498.0 17604.0 20226.0 20531.0 36606.0 True False 29261.08889477599 44383.59485037893 33227.19658254214 34058.70218118119 38612.22600459104 33561.08174381685 18422.620881664225 20284.85431140544 24637.77368407024 35549.08966618982 0.8231178117229186 1.2485156516565168 0.9346848792627173 0.9580752278327364 1.086166379144007 0.9440771074297373 0.5182304541313104 0.5706152956906249 0.6930634206226337 1.0 15.11752499562792 -7.121530656699848 5.422727384457907 0.6616188755454883 1.0160404244145442 0.4660947961607529 0.15851426890985162 0.1762939406652516 7.098703257177261 0.05837254396324916 0.0450840334908109 7.55908699117453e-08 7.121530656699848 0.35442154886905597 LEPKEESPT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LEPKEESPTR 10 1 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 LEPKEES(0.012)PT(0.988)R 140.45 0.014679 17005000.0 2601.5 2679.0 3626.5 4607.6 2853.4 3294.0 2663.6 2494.3 1621.2 2280.5 True False 2662.109888362186 2365.341434566689 3134.041218938594 3802.9691553639805 2595.3104738086863 3260.865350712702 2462.6825075233364 2428.143061371742 2751.0579922368443 2573.224388951108 1.0345424595665789 0.9192130483151701 1.2179432281131475 1.4779003229151495 1.0085830388334618 1.2672293037148963 0.9570414916388889 0.9436188588129684 1.0691092483225781 1.0 11.329361552348624 -7.280647169259039 24.332581837526924 0.9877439506905573 1.154539725423579 0.22031221941735513 0.14900421810282707 993.5365397571281 1258613.9894061545 0.0662812955670445 0.044772654517438296 5.240259943638869e-08 7.280647169259039 0.16679577473302165 LEPNS(ph)PMHGGTLLEDVVGGR ddPTM_A459_Selumetinib_30min_R1 7 LEPNSPMHGGTLLEDVVGGR 20 0 Q7Z4H7;Q5VY60;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 LEPNS(1)PMHGGTLLEDVVGGR;LEPNS(1)PMHGGTLLEDVVGGR;LEPNS(1)PMHGGTLLEDVVGGR;LEPNS(1)PMHGGTLLEDVVGGR;LEPNS(0.996)PMHGGT(0.004)LLEDVVGGR;LEPNS(1)PMHGGTLLEDVVGGR;LEPNS(0.999)PMHGGT(0.001)LLEDVVGGR 161.41 4.788800000000001e-07 30439600.0 6626.87 6529.030000000001 5747.379999999999 6605.800000000001 7154.04 5881.5 7094.07 6675.960000000001 3970.49 6039.63 True False 6781.26317735565 5764.608132336298 4966.917364098522 5452.221036223493 6506.958345148349 5822.337449974726 6558.958588431479 6498.891854225758 6737.631536884077 6814.875341478088 0.9950678240704037 0.8458860717892462 0.7288346617094892 0.8000470680716741 0.9548169290117998 0.8543571464231525 0.9624473317231504 0.9536332696609832 0.9886654119520172 1.0 12.734471551982194 -7.233467642130595 1.0271635312389669 0.9902989460566065 0.844697707522541 0.38217516479059255 0.0704260091744644 0.5960985076987354 1.2304483101985402 0.05327669091921205 0.031033978950431976 5.84160729387558e-08 7.233467642130595 -0.14560123853406548 LEPNS(ph)PMHGGTLLEDVVGGR ddPTM_A459_Selumetinib_30min_R2 4 LEPNSPMHGGTLLEDVVGGR 20 0 Q7Z4H7;Q5VY60;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 LEPNS(0.998)PMHGGT(0.002)LLEDVVGGR;LEPNS(0.983)PMHGGT(0.017)LLEDVVGGR;LEPNS(0.997)PMHGGT(0.003)LLEDVVGGR;LEPNS(1)PMHGGTLLEDVVGGR 105.52 0.00032699 12158900.0 23852.9 24785.8 28421.800000000003 30107.2 32415.0 21921.199999999997 26533.399999999998 25094.1 24531.600000000002 32705.2 True False 22527.251308724208 26686.791161091704 26593.172331316066 26006.547422183106 28342.737906223243 24940.646319159183 27767.255674934662 25167.11967644811 29438.605470173767 31760.915897685405 0.7092758716812034 0.8402399744094445 0.8372923632612893 0.8188223383091527 0.8923778519966654 0.785262188266326 0.8742586569097718 0.7923927558487751 0.9268815031974289 1.0 14.954964895997458 -14.522878745276875 0.1136661781360365 1.5561113770708845 0.739215850053701 0.5874015707971785 0.0494571131549848 119.07147672677529 0.8884336161958638 15.245005529281517 0.5439841407768643 3.0000000000239165e-15 14.522878745276875 -0.8168955270171835 LEPQELS(ph)PLSATVFPK ddPTM_A459_Selumetinib_30min_R1 1 LEPQELSPLSATVFPK 16 0 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2;Q9H869-7;Q9H869-5;Q9H869-6;Q9H869-4;Q9H869-3;Q9H869-2;Q9H869;Q9H869-8;Q9H869-9 Q3T8J9-3;Q9H869-7 GON4L;YY1AP1 GON-4-like protein;YY1-associated protein 1 1 LEPQELS(0.989)PLS(0.011)ATVFPK 189.44 9.6197e-07 27681000.0 6262.3 6894.0 7547.5 8769.4 7870.2 6414.3 6842.2 6712.9 3831.3 5953.2 True False 6408.199405685383 6086.8472750663495 6522.590955449892 7237.9889120255375 7158.341799596664 6349.777965718424 6326.087345313174 6534.852085427722 6501.4362729194545 6717.351209078594 0.9539771267318301 0.9061380126797435 0.9710063911254959 1.0775063989870433 1.0656494765261142 0.9452800319769807 0.9417532519013415 0.9728316835058107 0.9678571315629101 1.0 12.713676745217342 -5.514931886229814 24.854725171456717 0.9956408108727487 0.9321862141318027 0.25892666219014737 0.044167645595698676 500.65762867683753 1565861.4703704116 0.013437435848411353 0.02471801500748219 3.0554002777495768e-06 5.514931886229814 -0.063454596740946 LEPQELS(ph)PLSATVFPK ddPTM_A459_Selumetinib_30min_R2 1 LEPQELSPLSATVFPK 16 0 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2;Q9H869-7;Q9H869-5;Q9H869-6;Q9H869-4;Q9H869-3;Q9H869-2;Q9H869;Q9H869-8;Q9H869-9 Q3T8J9-3;Q9H869-7 GON4L;YY1AP1 GON-4-like protein;YY1-associated protein 1 1 LEPQELS(0.696)PLS(0.303)AT(0.001)VFPK 190.55 1.017e-06 8437200.0 28475.0 26134.0 29325.0 30825.0 33073.0 19661.0 23501.0 23357.0 24286.0 26141.0 True False 26892.473494456517 28138.393765945442 27438.26142664586 26626.581823909062 28918.074063628603 22369.124285211972 24593.84306634804 23424.96500304048 29143.878607536393 25386.241407525213 1.059332614968548 1.1084111788838662 1.08083197454005 1.0488587655207666 1.1391238899609792 0.8811514838341181 0.9687863071788846 0.9227425449478569 1.1480186507206738 1.0 14.631759190284294 -6.746331001382722 24.9999998521295 0.9783515903024865 1.085987617757427 0.35836958331642466 0.06879624008138199 258.2990385040276 427409.4834261652 0.022223441765110007 0.022140631910817575 1.7933662758516473e-07 6.746331001382722 0.1076360274549405 LEPQELSPLS(ph)ATVFPK ddPTM_A459_Selumetinib_30min_R1 1 LEPQELSPLSATVFPK 16 0 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2;Q9H869-7;Q9H869-5;Q9H869-6;Q9H869-4;Q9H869-3;Q9H869-2;Q9H869;Q9H869-8;Q9H869-9 Q3T8J9-3;Q9H869-7 GON4L;YY1AP1 GON-4-like protein;YY1-associated protein 1 1 LEPQELS(0.147)PLS(0.853)ATVFPK 189.59 9.696600000000002e-07 27350000.0 7283.1 8003.0 8680.6 9244.7 8383.5 6845.3 7743.7 7045.7 3867.4 6367.3 True False 7452.782059554347 7066.005039506234 7501.822199122669 7630.286689511539 7625.213905227143 6776.442497035114 7159.586474511361 6858.825148340971 6562.695336279776 7184.604977754165 1.0373266286219693 0.9834924900373572 1.044152353866456 1.062032876287193 1.061326813212034 0.9431892940554348 0.9965177621706038 0.9546558467136451 0.9134385754818782 1.0 12.81069312160889 -6.7647805223622886 24.999999933047793 0.9609111212527461 1.0363706252597797 0.6026231272445728 0.030889388646540256 65.12051497080525 487257.208539511 0.01113676978386344 0.010222746812965564 1.7187767789484027e-07 6.7647805223622886 0.0754595040070336 LEPQELSPLS(ph)ATVFPK ddPTM_A459_Selumetinib_30min_R2 1 LEPQELSPLSATVFPK 16 0 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2;Q9H869-7;Q9H869-5;Q9H869-6;Q9H869-4;Q9H869-3;Q9H869-2;Q9H869;Q9H869-8;Q9H869-9 Q3T8J9-3;Q9H869-7 GON4L;YY1AP1 GON-4-like protein;YY1-associated protein 1 1 LEPQELS(0.214)PLS(0.76)AT(0.026)VFPK 106.19 0.003535800000000001 10331000.0 33741.0 36498.0 34128.0 37233.0 37972.0 27703.0 31020.0 28913.0 28988.0 32487.0 True False 31865.81029592477 39297.27924043301 31932.241635756887 32161.801169492483 33201.617886012915 31518.836787204487 32462.491464963914 28997.13204319519 34786.40999239336 31549.015898637066 1.010041340062889 1.2455944542514454 1.0121469949601938 1.0194232768725406 1.0523820455346515 0.999043421464253 1.0289541698942917 0.9191136781051824 1.1026147409528597 1.0 14.945307383796928 -5.3814724579681315 22.746663953453343 1.0149936183139812 1.128132736514096 0.29692190160310816 0.06834719226044489 8.528581271756199 1580.4159974532515 0.01640203191833696 0.03414355527874201 4.1545839789393165e-06 5.3814724579681315 0.11313911820011491 LEPSTSTDQPVT(ph)PEPTSQATR ddPTM_A459_Selumetinib_30min_R1 1 LEPSTSTDQPVTPEPTSQATR 21 0 Q14676-3;Q14676;Q14676-2 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 LEPST(0.001)STDQPVT(0.672)PEPT(0.249)S(0.071)QAT(0.006)R 168.27 6.9427e-10 3289900.0 680.06 1076.5 1221.6 1288.3 1068.1 712.69 955.77 922.46 534.67 874.05 True False 695.9040748335913 950.4628795487272 1055.7134297684788 1063.322589386105 971.4905435883704 705.5209856707459 883.6754994051579 897.9933642276301 907.2959392482569 986.2428314679745 0.7056112882440645 0.9637209510907262 1.0704396484150873 1.0781549487192732 0.9850419314504462 0.7153623460264975 0.8960019492256789 0.9105195349212432 0.9199518721954014 1.0 9.945799098671985 -4.7588699689603615 24.91235828975615 0.94603438283409 0.7056109560291637 0.35798445006978274 0.09763895152218544 86.53261089840775 838819.4164806686 0.02723919323231347 0.18039204228913702 1.742328461571225e-05 4.7588699689603615 -0.24042342680492634 LEPSTSTDQPVT(ph)PEPTSQATR ddPTM_A459_Selumetinib_30min_R2 2 LEPSTSTDQPVTPEPTSQATR 21 0 Q14676-3;Q14676;Q14676-2 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 LEPSTS(0.001)T(0.056)DQPVT(0.843)PEPT(0.077)S(0.023)QATR;LEPSTS(0.001)T(0.024)DQPVT(0.974)PEPTSQATR 151.96 3.0064e-06 21805000.0 42190.0 49994.0 61713.0 56111.0 53351.0 53150.0 43076.0 59864.0 44810.0 61944.0 True False 39845.24869995154 53828.37904395334 57742.45276803398 48468.58500312606 46648.57041600853 60470.93005233793 45079.11935347472 60038.19432898132 53773.25209601033 60155.515770159596 0.6623706602764587 0.8948203394950383 0.9598862552962661 0.8057213770440169 0.7754662198266573 1.0052433144016828 0.7493763252851439 0.998049697693117 0.893903932292187 1.0 15.876409406384258 -1.522878745426601 0.08084120149941175 1.101573197730403 0.276096851842637 0.26195792350772895 0.09847096219437672 296.8994153999795 1.754609766655061 2.6733889311507824 27.357886899055643 0.029999999989896477 1.522878745426601 -0.8254763458877661 LEPTAPALS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 LEPTAPALSPR 11 0 Q96IF1 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 LEPTAPALS(1)PR;LEPTAPALS(1)PR;LEPTAPALS(1)PR 176.87 6.794800000000001e-05 203320900.0 7897.9 8751.5 8873.0 9306.1 9829.2 7524.4 8593.7 7560.9 4100.74 5652.84 True False 8081.905703361796 7726.870311538026 7668.095335900225 7680.964332132289 8940.150595486204 7448.7113676085755 7945.470290172434 7360.360370735518 6958.656273800471 6378.4370773244345 1.2670667759807888 1.211404959846248 1.2021903238899339 1.204207902189454 1.4016208809629478 1.1677956962355251 1.245676674999093 1.153944184367963 1.0909657317995245 1.0 12.638987245169057 -8.265669951929633 1.2269314052607383 1.0025282367347839 1.2453472035082815 0.6461643200366587 0.060114461456175564 0.27581400712120735 0.8265613620654689 0.05653016595384926 0.018192783322558987 5.424129479944902e-09 8.265669951929633 0.24281896677349768 LEPTAPALS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 LEPTAPALSPR 11 0 Q96IF1 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 LEPTAPALS(1)PR;LEPTAPALS(1)PR;LEPTAPALS(1)PR 142.76 0.00089481 133000000.0 240027.0 204982.0 250890.0 263226.0 298074.0 180425.0 211382.0 225925.0 201621.0 255116.0 True False 226687.26024421115 220703.46027898605 234748.01054837822 227374.16470982265 260627.27930463004 205276.90601492135 221211.68184548663 226582.40434610288 241950.83376143052 247750.13820902767 0.9149833856114917 0.890830826067099 0.947519191090503 0.9177559550662542 1.0519763225509802 0.8285642441972262 0.8928821733243577 0.9145601531609823 0.9765921242687491 1.0 17.91852633666562 -8.387008919420563 3.6439753207017085 0.9985957924914711 0.9202295818211071 0.21436980445907206 0.053139905719507406 0.36633919077403054 8.247940385987333 0.051323294155291375 0.01363667122252714 4.101956784141285e-09 8.387008919420563 -0.07836621067036398 LEPTNVQTVTCS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 LEPTNVQTVTCSPR 14 0 J3KTI7;J3QR52;J3QLN7;Q99741 J3KTI7 CDC6 Cell division control protein 6 homolog 1 LEPTNVQT(0.001)VT(0.065)CS(0.934)PR;LEPTNVQTVT(0.004)CS(0.996)PR 187.75 8.959799999999999e-05 63167000.0 6293.5 7009.1 7197.8 7432.4 7251.8 5932.9 5710.700000000001 5632.9 3032.9 4590.0 True False 6440.126304980746 6188.4713135578095 6220.378294685292 6134.470863427213 6595.875970409275 5873.220412642196 5279.937301289051 5483.497193762133 5146.609785748291 5179.171210386136 1.2434665786035288 1.1948767596536791 1.2010373942091648 1.1844502941175898 1.273538893092031 1.134007773456926 1.019456026226907 1.0587595912577115 0.9937130047810453 1.0 12.33850553579204 -7.084765136039906 3.2513962241637793 1.0226813067865892 1.2150928017900402 0.9080679830404306 0.030089357934438385 0.0723287093507682 1.4674475051574347 0.011974801912172572 0.009227194885655906 8.226874343046294e-08 7.084765136039906 0.192411495003451 LEPTNVQTVTCS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 LEPTNVQTVTCSPR 14 0 J3KTI7;J3QR52;J3QLN7;Q99741 J3KTI7 CDC6 Cell division control protein 6 homolog 1 LEPTNVQTVT(0.003)CS(0.997)PR;LEPTNVQTVT(0.297)CS(0.703)PR;LEPTNVQTVT(0.001)CS(0.999)PR;LEPTNVQTVTCS(1)PR 160.03 0.00029381 85597000.0 159924.0 163102.0 187145.0 201633.0 222433.0 158206.0 154984.0 165650.0 137776.0 162975.0 True False 151036.06430649565 175611.3989444107 175104.29444806985 174170.23756367408 194488.9779637498 179997.4404489216 162191.0630949697 166132.01407516608 165335.04978308248 158269.48829009713 0.9542967879548387 1.1095720397005835 1.10636798248261 1.1004662960963896 1.2288469500025478 1.1372845290243097 1.0247778320839995 1.0496780893778936 1.0446426002214315 1.0 17.2720236292463 -7.269132857222087 24.37180069781762 1.0339144652068812 1.1116253194191605 0.25152960036074945 0.06395717915139976 655.7038789239922 2077163.0505580497 0.027742533483579475 0.019133383880735693 5.381051428681298e-08 7.269132857222087 0.0777108542122793 LEPVSPPS(ph)PPHTDPELELVPPR ddPTM_A459_Selumetinib_30min_R1 1 LEPVSPPSPPHTDPELELVPPR 22 0 C9J0Q5;C9JE98;C9J330;H7C1Y3;H0YGK8;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 LEPVSPPS(0.998)PPHT(0.001)DPELELVPPR 70.449 0.0027004 7182800.0 1968.9 2613.4 2621.7 2495.3 2737.7 2393.0 2278.6 2614.2 1206.5 2048.0 True False 2014.77153918751 2307.4219130633032 2265.6875399672717 2059.5426975821983 2490.0755183801907 2368.9285926701577 2106.7233674886165 2544.8629238816548 2047.3423807264694 2310.880749209325 0.8718630504308239 0.9985032390151654 0.9804432966705372 0.8912371174007474 1.077543927453711 1.0251193591364218 0.9116538653971817 1.101252379532084 0.8859576079064113 1.0 11.174227097490869 -4.758118648387884 24.77467580126968 0.9875744521415418 0.8718628705414151 0.1948015343225532 0.06937022910975651 134.99194975022044 1006937.598281288 0.016277121917284868 0.11417950819889068 1.745345262929485e-05 4.758118648387884 -0.11571158160012673 LEPVSPPS(ph)PPHTDPELELVPPR ddPTM_A459_Selumetinib_30min_R2 1 LEPVSPPSPPHTDPELELVPPR 22 0 C9J0Q5;C9JE98;C9J330;H7C1Y3;H0YGK8;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 LEPVS(0.004)PPS(0.996)PPHTDPELELVPPR 86.258 0.00039048 3511400.0 22767.0 19804.0 22745.0 23409.0 21739.0 16242.0 18369.0 19540.0 15264.0 18080.0 True False 21501.70128352208 21322.903120103445 21281.611462883557 20220.653817222617 19007.95247087419 18479.18806980382 19223.19489748297 19596.85816497887 18317.226511794266 17557.983422518493 1.2246110937743389 1.2144277965746546 1.2120760653862692 1.1516501257934435 1.0825817528962967 1.0524664265318682 1.0948407020836348 1.1161223754116019 1.0432420438614851 1.0 14.099839536871682 -2.719346407490954 0.19768558391053184 1.0002625334056292 1.7976402350630187 0.8489579659440499 0.029143993147224042 13.858859243880998 0.2503159063950226 0.06530420188269027 3.097686349503889 0.0019083305044876684 2.719346407490954 0.7973777016573895 LEPVYS(ph)PPGSPPPGDPR ddPTM_A459_Selumetinib_30min_R1 1 LEPVYSPPGSPPPGDPR 17 0 E9PJN1;O75676-2;O75676;A0A0A6YYC0 E9PJN1 RPS6KA4 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-4 1 LEPVYS(0.786)PPGS(0.214)PPPGDPR 74.141 0.023528 48147000.0 1195.4 1031.4 1410.1 1357.4 1262.0 1196.2 959.17 1025.8 415.7 695.47 True False 1223.2504941565087 910.6432085151482 1218.6161651248615 1120.3555715537511 1147.8523228241968 1184.1673140627004 886.8190346678024 998.5924517320024 705.4125384732647 784.7403489514693 1.5587964806333134 1.1604388760332052 1.552890923415771 1.4276767762110283 1.4627160746327108 1.5089925166265827 1.130079568168918 1.2725131988768916 0.8989120279284755 1.0 9.61607157085453 -7.780002424788464 1.2798412405096646 0.968066612259122 1.435137281404727 0.6531848403601852 0.13394174790235683 0.28427936855976665 0.8486497867319722 0.10818972763500552 0.041547225056436626 1.6595776415221017e-08 7.780002424788464 0.4670706691456049 LEPVYS(ph)PPGSPPPGDPR ddPTM_A459_Selumetinib_30min_R2 1 LEPVYSPPGSPPPGDPR 17 0 E9PJN1;O75676-2;O75676;A0A0A6YYC0 E9PJN1 RPS6KA4 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-4 1 LEPVYS(0.944)PPGS(0.056)PPPGDPR 87.13799999999998 0.010793 99413000.0 13318.0 13465.0 15887.0 16920.0 20233.0 10457.0 9576.7 9184.1 11640.0 13818.0 True False 12577.838876178126 14497.722203201016 14864.847716457725 14615.466811371967 17691.14965468502 11897.356830805233 10022.035525871052 9210.824210490398 13968.32524877394 13419.038436524364 0.9373129778019985 1.0803845798474394 1.1077431357524181 1.0891590243598324 1.3183619480910562 0.8866027835811715 0.7468519874414218 0.6863997188815023 1.0409333958500713 1.0 13.711993676083134 -6.950705814768478 13.345198693877176 0.838743718520829 1.1041362363856 0.4365357777119351 0.13155279742970002 1.1035420942007195 297.5054897784661 0.04610236944731569 0.04065605163750508 1.1201964324955501e-07 6.950705814768478 0.265392517864771 LEQLCEEFS(ph)EEER ddPTM_A459_Selumetinib_30min_R1 2 LEQLCEEFSEEER 13 0 Q9H3C7-3;Q9H3C7 Q9H3C7-3 GGNBP2 Gametogenetin-binding protein 2 1 LEQLCEEFS(1)EEER;LEQLCEEFS(1)EEER 203.27 6.0444e-05 26226000.0 3958.8 5375.7 3466.1 3600.2 4493.1 3391.0 5458.4 4332.8 2215.65 4164.7 True False 4051.032337516132 4746.310544904871 2995.4226579244614 2971.4926541239233 4086.6998983212366 3356.889618781653 5046.668493416951 4217.880069082103 3759.796225326652 4699.27981261332 0.8620538676251562 1.01000807233596 0.6374216427556534 0.6323293722898029 0.8696438733765416 0.7143412932703939 1.0739238127236446 0.8975588254525525 0.8000792409158093 1.0 12.198223958391953 -7.244485745397241 24.955507874593224 0.9343537225334979 0.7875816990497126 0.26834297290800013 0.12527651285370248 1251.3499588748984 1841971.7786800493 0.05067171359053764 0.03914932712099285 5.695269170818383e-08 7.244485745397241 -0.14677202348378526 LEQLCEEFS(ph)EEER ddPTM_A459_Selumetinib_30min_R2 2 LEQLCEEFSEEER 13 0 Q9H3C7-3;Q9H3C7 Q9H3C7-3 GGNBP2 Gametogenetin-binding protein 2 1 LEQLCEEFS(1)EEER;LEQLCEEFS(1)EEER 150.76 0.00048372 5261100.0 12855.5 13808.900000000001 20044.9 17865.4 26632.0 21170.0 19231.0 18384.1 21349.0 21093.0 True False 12141.042774643924 14867.998227388236 18755.232957236956 15432.101700466003 23286.25006689919 24085.975337873842 20125.27960550358 18437.594687348395 25619.396540899907 20483.990283804353 0.5927088719741889 0.7258350556406779 0.9156044646274688 0.7533738049401136 1.1368024366478264 1.1758439153780207 0.9824882421183149 0.9000978047683444 1.2507034120766918 1.0 14.32220915943379 -5.348310948756679 0.8116519222367147 1.0670849959166835 0.524259260350427 0.6327272070731637 0.12115725836351784 0.879333669587136 0.7625445516041226 0.05181839076066825 0.3720151967383284 4.4842420952307836e-06 5.348310948756679 -0.5428257355662565 LEQLCEEFS(ph)EEERVR ddPTM_A459_Selumetinib_30min_R1 4 LEQLCEEFSEEERVR 15 1 Q9H3C7-3;Q9H3C7 Q9H3C7-3 GGNBP2 Gametogenetin-binding protein 2 1 LEQLCEEFS(1)EEERVR;LEQLCEEFS(1)EEERVR;LEQLCEEFS(1)EEERVR;LEQLCEEFS(1)EEERVR 136.49 0.00022299 36399500.0 3671.71 3604.69 5275.59 6076.700000000001 4073.39 4190.0199999999995 3971.71 3363.74 1708.6599999999999 2714.34 True False 3757.253699096028 3182.651219025085 4559.1938547415575 5015.518418786415 3704.9525937154135 4147.872203033769 3672.120717057933 3274.522688232603 2899.4712244111806 3062.751978910568 1.2267574145629958 1.0391475512676562 1.488593880972131 1.637585561391247 1.2096809076369541 1.354295820097448 1.1989611768577224 1.069143930288917 0.9466882216961404 1.0 11.58061282715122 -7.697590263586843 1.7769015701745314 0.9738576687584524 1.3312279884984073 0.47343823142716834 0.15283933748507336 0.35795264328545184 2.1948169995803197 0.119684748768289 0.050644847890931786 2.0063640448009683e-08 7.697590263586843 0.3573703197399549 LEQLESGEEELVLAEYES(ph)DEEKKVASR ddPTM_A459_Selumetinib_30min_R1 1 LEQLESGEEELVLAEYESDEEKKVASR 27 2 F5GXJ8;F6WZM0;F5H235;C9K0E8;B4DMS8;Q96FC9-5;Q96FC9-4;Q96FC9-3;Q96FC9-2;Q96FC9 F5GXJ8 DDX11 Probable ATP-dependent RNA helicase DDX11 1 LEQLESGEEELVLAEY(0.452)ES(0.509)DEEKKVAS(0.039)R 53.481 0.005083600000000001 3817600.0 1366.3 1069.5 1857.5 1619.4 1037.2 1217.2 1291.6 1259.4 846.04 1233.5 True False 1398.1321316429967 944.2824428029395 1605.261702517149 1336.6021899028624 943.3854431325328 1204.9560731291747 1194.1735721268742 1225.996620892264 1435.6680876832347 1391.8317403074716 1.0045266903700107 0.6784458318175275 1.153344657999054 0.9603188023342474 0.6778013576009756 0.8657340095311996 0.8579870235342295 0.8808511728734015 1.0314954359110098 1.0 10.442769097790991 -8.257067662772142 23.072334332250726 1.0157477444015213 0.8810219996597304 0.1320779353792535 0.13390186753463926 240.18285873938126 1267652.5061559442 0.09808332216605667 0.034000994183078066 5.532639043768316e-09 8.257067662772142 -0.1347257447417909 LEQTSVRDPS(ph)PEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEK ddPTM_A459_Selumetinib_30min_R1 1 LEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEK 48 3 O15234 O15234 CASC3 Protein CASC3 1 LEQT(0.049)S(0.049)VRDPS(0.677)PEADAPVLGS(0.112)PEKEEAAS(0.112)EPPAAAPDAAPPPPDRPIEK 40.742 0.011417 11057000.0 795.24 890.96 867.05 951.47 905.93 961.38 933.82 755.35 452.36 738.58 True False 813.7675447323254 786.6459890039334 749.309372364734 785.3136258039253 823.9887914549321 951.7093900631994 863.3812055772045 735.3156642774112 767.621880932802 833.3839373784296 0.9764617581809756 0.9439178675299174 0.8991166481103916 0.9423191287730854 0.9887265094728707 1.1419819213902604 1.0359945360755778 0.8823252180627442 0.9210903240438076 1.0 9.702837483614317 -4.439451702542326 19.675040708077454 0.9728606087766329 1.1347627955687518 0.00022953088405142097 0.07187603220004439 33386.99547830947 1892325.1876567698 0.019425012093154257 296957.5401878567 3.635367308566634e-05 4.439451702542326 0.16190218679211887 LEQTVSMATTT(ph)QPMTQHLHVT(ph)YKK ddPTM_A459_Selumetinib_30min_R1 1 LEQTVSMATTTQPMTQHLHVTYKK 24 1 B5MCC0;Q8WY91-2;Q8WY91 B5MCC0 THAP4 THAP domain-containing protein 4 2 LEQT(0.095)VS(0.05)MAT(0.099)T(0.105)T(0.658)QPMT(0.284)QHLHVT(0.44)Y(0.268)KK 45.15 0.027042 9431800.0 488.08 628.81 404.91 524.15 459.98 567.53 572.42 423.02 371.57 399.5 True False 499.4513143616433 555.1886328741617 349.9254460114234 432.6170420140699 418.374890216065 561.8211634760108 529.2418985420139 411.800135437387 630.5271516009403 450.77971645953386 1.1079720229747265 1.2316184881490793 0.7762670617918895 0.9597083147659897 0.9281138324102527 1.246331950977313 1.1740588123590152 0.9135285382219587 1.3987478330949752 1.0 8.816278790418846 -6.753389333530323 24.995572548962727 1.1428493016168424 0.9988129502575729 0.16305566453463816 0.1650239600027304 359.7663573263988 1117080.9263450499 0.055312530033369126 0.05438395636899223 1.764455323872399e-07 6.753389333530323 -0.1440363513592695 LES(ph)LNIQR ddPTM_A459_Selumetinib_30min_R1 2 LESLNIQR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 LES(1)LNIQR;LES(1)LNIQR 118.23 0.008469200000000001 44949000.0 4773.5 5915.2 5664.5 6887.299999999999 5458.5 5152.799999999999 5001.9 5160.0 3287.2 4346.2 True False 4884.7132623858915 5222.645634098124 4895.292012871269 5684.562345632939 4964.77963877645 5100.967510368067 4624.602655947207 5023.140037957818 5578.138312411152 4904.077105573034 0.9960514806822395 1.0649599346965948 0.9982086144828798 1.1591502790959292 1.0123779728370164 1.0401483093671764 0.9430118157587224 1.0242783565228777 1.1374491453391116 1.0 12.259765947001005 LES(ph)LNIQR ddPTM_A459_Selumetinib_30min_R2 1 LESLNIQR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 LES(1)LNIQR 84.31 0.036854000000000005 3600100.0 16190.0 17796.0 19146.0 19999.0 18977.0 14062.0 17262.0 12891.0 11440.0 17726.0 True False 15290.224613705044 19160.895976841086 17914.167204588633 17275.10169980072 16592.93960346748 15998.912857873496 18064.71720400409 12928.510675780059 13728.319660307037 17214.20432232096 0.888233015445206 1.1130863569451148 1.0406619364544234 1.0035376237169906 0.963909762704053 0.9294018217925041 1.0494076209250234 0.7510373662183262 0.7974995186101099 1.0 14.071311877519667 -7.755060429959904 24.99953993165744 0.8307013240190793 1.0005889275104165 0.3873894535727519 0.08473552240862409 129.4410758843318 507294.2401848948 0.03987273716933147 0.022302118594865878 1.75767902447507e-08 7.755060429959904 0.16988760349133725 LES(ph)LSYQLSGLQK ddPTM_A459_Selumetinib_30min_R1 2 LESLSYQLSGLQK 13 0 Q03252 Q03252 LMNB2 Lamin-B2 1 LES(0.983)LS(0.017)YQLSGLQK;LES(0.753)LS(0.247)YQLSGLQK 192.32 0.00017811 15146000.0 3465.7000000000003 4897.5 3812.3999999999996 4291.9 3496.1000000000004 4702.7 4413.5 3558.2 2297.42 3034.87 True False 3546.4440669217106 4324.09842321402 3294.6970200142023 3542.400233941022 3179.8783722865874 4655.395107709964 4080.5861416707626 3463.8249773375014 3898.553943082144 3424.4251266371616 1.035631948654802 1.262722431738594 0.9621168219991557 1.0344510692863984 0.9285875014616766 1.3594676290328571 1.1916120197605142 1.011505537205023 1.138455010377343 1.0 11.741646101476695 LES(ph)LSYQLSGLQK ddPTM_A459_Selumetinib_30min_R2 2 LESLSYQLSGLQK 13 0 Q03252 Q03252 LMNB2 Lamin-B2 1 LES(0.983)LS(0.017)YQLSGLQK;LES(0.969)LS(0.031)YQLSGLQK 201.72 8.953e-05 7092300.0 32573.0 26593.0 37541.0 40237.0 39465.0 29289.0 21826.9 24952.0 22271.7 33721.0 True False 30762.723060050303 28632.59759002782 35125.65293155031 34756.65118730342 34507.053878423576 33323.293890929956 22841.894099181834 25024.606188974023 26726.662323291977 32747.387112320044 0.9393947356635644 0.8743475469301129 1.072624597836556 1.0613564700014635 1.0537345700305207 1.0175863428930867 0.6975180652073576 0.7641710803717651 0.816146406784223 1.0 14.999092179314623 -7.24500734977956 24.85073791400854 0.7998064793650751 1.0054180123678353 0.486773923070001 0.09151184826994899 596.4073206413846 901969.0276902064 0.03572165811201687 0.027587168502501463 5.6884330394679304e-08 7.24500734977956 0.20561153300276025 LES(ph)PSFTGTGDTEIAHATEDLENNGSK ddPTM_A459_Selumetinib_30min_R1 1 LESPSFTGTGDTEIAHATEDLENNGSK 27 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 LES(0.75)PS(0.131)FT(0.092)GT(0.017)GDT(0.01)EIAHATEDLENNGSK 95.878 0.00014497 0.0 822.2 569.61 429.86 509.63 591.64 749.62 760.77 649.89 346.1 496.58 True False 841.3556602772973 502.91979639549555 371.4873730519633 420.6326874399135 538.1262664625256 742.0795034005025 703.3845064005591 632.6528060597692 587.306421856139 560.320880098812 1.5015604275338177 0.8975567648073478 0.6629904153963562 0.7506996479690983 0.9603894582112084 1.3243830986088498 1.2553244602923201 1.129090184803039 1.048160871236082 1.0 9.130109444708937 -6.616025833301861 7.921737834403765 1.16522827840693 0.9196041281142571 0.151949334953987 0.22569387817164127 0.4116208557925821 30.6776082341113 0.07811763843796432 0.07805793830442082 2.4208850400386913e-07 6.616025833301861 -0.24562415029267304 LES(ph)PSFTGTGDTEIAHATEDLENNGSK ddPTM_A459_Selumetinib_30min_R2 2 LESPSFTGTGDTEIAHATEDLENNGSK 27 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 LES(0.617)PS(0.252)FT(0.089)GT(0.032)GDT(0.01)EIAHATEDLENNGSK;LES(0.615)PS(0.185)FT(0.185)GT(0.01)GDT(0.005)EIAHATEDLENNGSK 55.526 0.026815 5198300.0 31933.0 23538.6 26987.0 32851.0 32217.0 24735.0 29157.0 30072.0 22349.0 33191.0 True False 30158.29169792731 25343.93493147178 25250.685801223924 28376.637128864095 28169.612436365693 28142.02172802595 30512.858273499427 30159.50454131239 26819.424483234434 32232.689589425416 0.9356430407166936 0.7862804889786911 0.78338749024245 0.8803682686837782 0.8739454508818681 0.8730894655858475 0.9466432575800248 0.9356806684604696 0.8320566736706045 1.0 14.976236955642582 -6.669173367395004 1.2418742129086469 0.9223321461342526 0.8356020677457069 0.28008061426904896 0.057117590921071715 0.5951443589371987 1.934025896174214 0.027046022771055826 0.026584217145230397 2.1420353445256608e-07 6.669173367395004 -0.08673007838854574 LES(ph)SEGEIIQTVDR ddPTM_A459_Selumetinib_30min_R1 2 LESSEGEIIQTVDR 14 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 LES(0.947)S(0.053)EGEIIQTVDR;LES(0.605)S(0.395)EGEIIQTVDR 198.81 7.9124e-05 6488600.0 2423.6 3137.6 1814.83 2120.8 2247.6 1944.55 2846.2 2116.93 1108.1 2648.5 True False 2480.0651644953273 2770.248333369332 1568.3860541476167 1750.4420923465432 2044.3049768460091 1924.9895925101343 2631.508842511233 2060.7821396422582 1880.3647675781194 2988.460773574658 0.8298804476288268 0.9269816615513711 0.5248140005771553 0.5857336685911207 0.6840661905027137 0.6441408264521241 0.8805565948130363 0.6895797856423748 0.6292084487791065 1.0 11.545186890788255 -7.231055002641865 24.935177818847468 0.7739679438165925 0.6958384576504704 0.09456272165783786 0.14356406760906104 2209.465953925015 1813218.174143251 0.05754246872052638 0.04456568452880351 5.8741495273501246e-08 7.231055002641865 -0.07812948616612214 LESEST(ph)SPSLEMK ddPTM_A459_Selumetinib_30min_R1 2 LESESTSPSLEMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 LESES(0.063)T(0.932)S(0.005)PSLEMK;LESES(0.003)T(0.498)S(0.498)PS(0.001)LEMK 257.2 3.6791e-29 57087000.0 8813.8 9215.3 10773.1 10086.2 9238.1 8584.0 8938.6 8775.7 4298.1 7285.1 True False 9019.14439133063 8136.368391923256 9310.172192402422 8324.834511422909 8402.51548611903 8497.6527536484 8264.354205491856 8542.939928509004 7293.561779196389 8220.213547883235 1.0971910083349508 0.9898001243554592 1.1325949305538248 1.0127272804934142 1.0221772752220943 1.0337508513798415 1.0053697701831588 1.0392600969239871 0.8872715698577605 1.0 13.004960157944998 -7.462725066521458 0.7934202036907531 0.9613364992093834 1.0561011187009006 0.33112339288754733 0.050651242770909974 0.780877109979124 0.9282017151731174 0.04158726828023178 0.022071505810342045 3.445679931643382e-08 7.462725066521458 0.09476461949151727 LESEST(ph)SPSLEMK ddPTM_A459_Selumetinib_30min_R2 3 LESESTSPSLEMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 LES(0.002)ES(0.017)T(0.925)S(0.054)PS(0.002)LEMK;LESES(0.01)T(0.656)S(0.271)PS(0.063)LEMK;LESES(0.049)T(0.59)S(0.331)PS(0.03)LEMK 232.5 6.256600000000001e-13 52029800.0 378051.0 360592.0 381281.0 394440.0 411136.0 306473.0 328101.0 352775.0 257080.0 330406.0 True False 357040.4388780607 388248.2469139744 356749.7955673652 340716.5915530473 359485.42007752607 348686.8738651017 343358.3466197973 353801.5168449547 308503.183415361 320866.3202821152 1.1127389081039736 1.2099999980447154 1.111833100007817 1.0618646146890056 1.1203588452706903 1.0867044991151638 1.0700978099474774 1.1026446045626785 0.9614695089971295 1.0 18.291612839587906 -7.020477853331196 0.29619294337087143 0.9815243256926531 1.1826792303216356 0.56861628403053 0.042517696026479736 1.6460946793438027 0.3490579240749244 0.0638810421932833 0.118025908417124 9.539423875016355e-08 7.020477853331196 0.20115490462898244 LESESTS(ph)PSLEMK ddPTM_A459_Selumetinib_30min_R2 2 LESESTSPSLEMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 LESEST(0.226)S(0.774)PS(0.001)LEMK;LESES(0.007)T(0.186)S(0.678)PS(0.129)LEMK 156.52 0.00036521 58621000.0 501406.0 454020.0 479664.0 541853.0 475942.0 427982.0 446835.0 485025.0 336945.0 477640.0 True False 473539.8618072503 488841.8740956059 448802.940458676 468051.6866514388 416149.91098453547 486932.635666222 467613.71288675524 486436.3424497885 404343.4150299089 463849.29214224144 1.0208916340483218 1.0538808237432868 0.9675619820091234 1.0090598273628684 0.8971662090128215 1.0497647488419621 1.0081156117046728 1.0486948038731094 0.8717129073593912 1.0 18.823296614279506 -5.26107618793086 24.98883610295615 0.9846081953039709 1.0373862294267644 0.1370698627311452 0.05564712320047684 63.95470025842211 4400085.455292996 0.013945874803261525 0.03266801835608824 5.4818078957111165e-06 5.26107618793086 0.05277803412279347 LESLYS(ph)DEEDESAVGADK ddPTM_A459_Selumetinib_30min_R1 1 LESLYSDEEDESAVGADK 18 0 Q9UP95-3;Q9UP95-5;Q9UP95-2;Q9UP95-6;Q9UP95;I3L4N6;Q9UP95-7 Q9UP95-3 SLC12A4 Solute carrier family 12 member 4 1 LES(0.143)LYS(0.857)DEEDESAVGADK 244.54 1.4359e-25 7365500.0 2837.0 2683.9 2705.4 2122.5 2533.4 3027.5 2954.1 3489.7 1387.5 3332.2 True False 2903.0965801589555 2369.667740288742 2338.021539698462 1751.8452192594934 2304.254417308097 2997.046098750062 2731.269858640446 3397.141819856863 2354.486161009513 3759.920328376616 0.7721165148763663 0.6302441363995259 0.6218274153452413 0.4659261543490924 0.6128466073915407 0.7971036184280179 0.7264169503878024 0.9035143096565597 0.6262063967791803 1.0 11.87648637659858 -6.7625510835882405 9.074628075697275 0.7995209406800906 0.6124694608541958 0.40050418056496373 0.11565302829552537 0.11195125588101452 114.05956775597934 0.038608919962573665 0.03615431076152865 1.7276227581233958e-07 6.7625510835882405 -0.18705147982589476 LESPTVSTLTPSS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 LESPTVSTLTPSSPGK 16 0 A0A087WTV6;A0A087WZR9;Q96C36 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase;Pyrroline-5-carboxylate reductase 2 1 LESPTVSTLTPS(0.26)S(0.74)PGK 125.73 0.00097884 0.0 15081.0 11610.0 12486.0 14310.0 10283.0 12476.0 18402.0 12845.0 12566.0 8823.2 True False 14242.858394026292 12500.449667966124 11682.664353728913 12360.953313873108 8991.157608813624 14194.455754148035 19257.729462871233 12882.376823395773 15079.551123375717 8568.451290573297 1.6622441922142657 1.4588925400928252 1.363451101902366 1.442612310520127 1.0493328728734648 1.6565952554068046 2.247515777332818 1.5034661908586096 1.7598922619733741 1.0 13.064818751856478 -6.972189376041352 24.80604793034563 1.710014446356857 1.3950240268656453 0.10019577458297335 0.32193599444823323 335.0555398069983 298856.0080359268 0.10974339255626357 0.09678274256022606 1.0661311286338827e-07 6.972189376041352 -0.31499041949121165 LESS(ph)EGEIIQTVDR ddPTM_A459_Selumetinib_30min_R1 1 LESSEGEIIQTVDR 14 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 LES(0.158)S(0.842)EGEIIQTVDR 127.03 0.0012498 1979200.0 988.34 1138.8 844.77 959.24 986.14 714.99 1051.0 845.14 519.38 868.9 True False 1011.3663990251325 1005.4687665862429 730.0548739894541 791.7267411648887 896.9438111171577 707.7978497589783 971.722223835045 822.7241417983857 881.3499259856727 980.4317788027263 1.0315520374708607 1.0255366954895027 0.7446258778769647 0.8075286402198443 0.9148457144182723 0.7219246306186848 0.9911166129495342 0.8391447111221463 0.8989405943797034 1.0 9.937273436911003 -5.227873732602308 21.655712242725883 0.858176488250178 1.0285450545287027 0.3558359941870425 0.08778605682886806 126.76873889763753 81785.30843913979 0.02128201395656337 0.056286842483583725 5.917336506544872e-06 5.227873732602308 0.1703685662785247 LESS(ph)EGEIIQTVDR ddPTM_A459_Selumetinib_30min_R2 2 LESSEGEIIQTVDR 14 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 LES(0.016)S(0.984)EGEIIQTVDR;LES(0.044)S(0.956)EGEIIQTVDR 222.88 4.353e-09 8486700.0 22009.2 21160.0 29526.0 30769.0 30516.0 20105.6 24095.9 24121.0 24306.6 26473.0 True False 20786.016773808333 22782.90395987623 27626.32930547813 26578.209120514428 26682.30726349865 22874.963899535003 25216.407095120034 24191.1881165535 29168.599183148497 25708.655704885645 0.8085221184808267 0.8861958486435598 1.0745925272252976 1.0338233716150134 1.0378725192709306 0.8897767414259575 0.980852806330435 0.9409744482266428 1.134582823698764 1.0 14.649966553758377 -5.052981660273994 4.518853521903511 1.0053865142791356 0.8220528562886593 0.5203366520727459 0.06472586886188506 0.15491937106729867 6.6563976502127735 0.016947748224200594 0.05443496925798165 8.851529879721537e-06 5.052981660273994 -0.1833336579904763 LESSDLT(ph)PPHS(ph)PPPSSR ddPTM_A459_Selumetinib_30min_R2 1 LESSDLTPPHSPPPSSR 17 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 2 LES(0.002)S(0.003)DLT(0.995)PPHS(0.999)PPPS(0.001)SR 102.9 0.011028 14135000.0 52187.0 42502.0 55297.0 47877.0 59475.0 37458.0 38219.0 44525.0 33958.0 44918.0 True False 49286.655461113354 45761.76673453023 51739.25122282139 41356.07000756833 52003.21878675387 42617.49949013123 39996.25922951177 44654.56037848944 40750.548865796 43621.10062902026 1.1298810610093575 1.0490740965872336 1.1861060467694913 0.9480748860347405 1.1921574200756675 0.9769927598245572 0.9169016520161587 1.0236917394235037 0.9341935044776349 1.0 15.412738551453765 -6.882093136145827 9.521475683001482 0.9673680106430801 1.0942696676526913 0.4566176589176022 0.07112963257587591 0.2615898797811282 20.60842533927084 0.02328976411234993 0.02054449693618002 1.3119185228041576e-07 6.882093136145827 0.1269016570096112 LESSDLT(ph)PPHSPPPSSR ddPTM_A459_Selumetinib_30min_R2 1 LESSDLTPPHSPPPSSR 17 0 Q9H7P9;Q9H7P9-3;H7BXC7 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 LES(0.007)S(0.007)DLT(0.987)PPHSPPPSSR 86.189 0.015338 5694000.0 20279.0 24113.0 25336.0 26539.0 29976.0 17724.0 18587.0 20401.0 19434.0 16690.0 True False 19151.97436326896 25962.389564484674 23705.909343751056 22924.34241767144 26210.146891159886 20165.32011754728 19451.332329441782 20460.36353243265 23321.343031329256 16208.116334172213 1.1816286339758122 1.6018141176434637 1.462594965077524 1.414374252073891 1.6171001213694398 1.2441495175495463 1.2000982673373197 1.2623529539515492 1.438868191127179 1.0 13.984428813819093 -6.794065095561061 23.8689710706468 1.2436782923053087 1.461739932951999 0.36143444332316044 0.14972994178030757 133.97090733348637 98011.81537781005 0.05046158052373565 0.04450736501236607 1.6067004097424563e-07 6.794065095561061 0.21806164064669042 LESTARPSES(ph)SEEFLEEEPEQR ddPTM_A459_Selumetinib_30min_R1 2 LESTARPSESSEEFLEEEPEQR 22 1 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 LESTARPS(0.001)ES(0.922)S(0.077)EEFLEEEPEQR;LES(0.002)T(0.005)ARPS(0.046)ES(0.474)S(0.474)EEFLEEEPEQR 111.49 2.4497e-05 12204400.0 1218.88 1646.46 1063.99 1005.2 1392.62 1364.69 1249.4 1312.4099999999999 703.27 1194.63 True False 1247.2775324723823 1453.6916977815126 919.5060020787192 829.6606899409394 1266.6577668870307 1350.9624576393794 1155.1567521022887 1277.6006234915158 1193.3978251914668 1347.9723971816088 0.9252990158257223 1.0784283868282063 0.6821400823943108 0.6154878925381744 0.9396763387257826 1.002218191161794 0.8569587585899635 0.9477943511030129 0.8853280880874621 1.0 10.396575239003125 LESTARPSES(ph)SEEFLEEEPEQR ddPTM_A459_Selumetinib_30min_R2 1 LESTARPSESSEEFLEEEPEQR 22 1 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 LES(0.001)T(0.001)ARPS(0.16)ES(0.612)S(0.226)EEFLEEEPEQR 59.537 0.0093271 4761400.0 6077.5 4541.4 5476.5 4300.0 6484.8 4339.5 5304.0 5800.0 3399.8 5084.9 True False 5739.736880160125 4889.7107770974435 5124.147952362358 3714.332582086259 5670.1214491524415 4937.226734941122 5550.646509676613 5816.8770397583085 4079.8549983489384 4938.0857248431585 1.1623404695637252 0.9902037043418781 1.037679019338027 0.7521806604935423 1.1482428141387793 0.9998260479971591 1.1240482281933069 1.1779619398857362 0.826201735993257 1.0 12.269736166451127 LETLGSASTS(ph)TPGRR ddPTM_A459_Selumetinib_30min_R2 1 LETLGSASTSTPGRR 15 1 Q96FF9;B5MBX0 Q96FF9 CDCA5 Sororin 1 LETLGSAS(0.002)T(0.013)S(0.493)T(0.493)PGRR 103.01 0.0030433000000000005 3907300.0 7716.4 11157.0 11152.0 10687.0 8133.2 7964.7 8040.3 8534.7 7352.3 8341.2 True False 7287.553379196642 12012.7060245907 10434.492461379528 9231.4121638967 7111.434704269471 9061.765128652047 8414.1898815522 8559.534564004352 8822.965440426166 8100.367882959695 0.8996570877388265 1.4829827729011147 1.2881504410842877 1.139628754802152 0.8779150289247246 1.1186856275644952 1.0387416970595467 1.0566846700889452 1.089205523490675 1.0 12.983771714988904 -5.993937332618429 6.73139824107768 1.0351432382446049 1.2449270760238338 0.2595411928935657 0.14633378364316985 0.17209332745371456 40.163787579462664 0.04057926979184047 0.05808023842616155 1.0140577006423784e-06 5.993937332618429 0.20978383777922893 LETLPLS(ph)PGSGAEPDTKPVFHTLTNGHAK ddPTM_A459_Selumetinib_30min_R1 2 LETLPLSPGSGAEPDTKPVFHTLTNGHAK 29 1 A0A087WXS2;E0YMJ8;A0A0C4DGS8;A0A087WZC2;P35680-3;P35680-4;P35680-2;P35680 A0A087WXS2 HNF1B Hepatocyte nuclear factor 1-beta 1 LET(0.023)LPLS(0.739)PGS(0.127)GAEPDT(0.109)KPVFHT(0.002)LTNGHAK;LET(0.005)LPLS(0.992)PGS(0.003)GAEPDTKPVFHTLTNGHAK 98.135 5.5684e-08 109536000.0 5217.0 5365.2 6134.3 6343.9 6637.8 4986.3 5863.299999999999 5532.200000000001 2751.16 4826.9 True False 5338.545949485113 4737.039889786189 5301.295753297954 5236.056954751616 6037.412161998772 4936.142349198164 5421.02656043009 5385.468084881835 4668.517583223736 5446.479632987547 0.9801828537375381 0.8697434322705415 0.9733435375742046 0.9613653786637758 1.1084980700987368 0.906299606685677 0.99532669278642 0.9887979847136148 0.8571624054091842 1.0 12.41110832059934 -5.47248733608213 23.99693835262826 0.9763839428011007 0.9241081286422703 0.07915530522333725 0.06631428083380522 545.992058157392 260005.10167966445 0.01693668284734072 0.03525541598279133 3.3690903978112613e-06 5.47248733608213 -0.052275814158830425 LETLPLS(ph)PGSGAEPDTKPVFHTLTNGHAK ddPTM_A459_Selumetinib_30min_R2 2 LETLPLSPGSGAEPDTKPVFHTLTNGHAK 29 1 A0A087WXS2;E0YMJ8;A0A0C4DGS8;A0A087WZC2;P35680-3;P35680-4;P35680-2;P35680 A0A087WXS2 HNF1B Hepatocyte nuclear factor 1-beta 1 LET(0.039)LPLS(0.767)PGS(0.149)GAEPDT(0.034)KPVFHT(0.01)LT(0.001)NGHAK;LET(0.009)LPLS(0.925)PGS(0.063)GAEPDT(0.002)KPVFHTLTNGHAK 63.268 0.00054901 14793000.0 83632.0 69208.6 87750.0 95831.0 87664.0 65082.2 68149.0 75997.0 62710.4 82940.0 True False 78984.06824542192 74516.67707927665 82104.26053497614 82778.65248230431 76650.86459389639 74046.68229261081 71318.06353468161 76218.13868801933 75254.23227497534 80545.30669600022 0.9806166427986818 0.925152316577833 1.0193549928968528 1.0277278202531819 0.9516490499340637 0.9193171561452119 0.8854403373725459 0.9462765965456834 0.9343093392021607 1.0 16.297512906362456 -6.508506084867747 15.774304334899005 0.9310387072586646 0.9864031378317338 0.29158672452522894 0.037140082334007465 6.579233264475607 7220.709294042297 0.012101574717930722 0.013124216652083505 3.1009439411326074e-07 6.508506084867747 0.05536443057306928 LETVVCTGS(ph)VPVDK ddPTM_A459_Selumetinib_30min_R1 1 LETVVCTGSVPVDK 14 0 J3KNG8;Q8TF40;A0A087WX11;Q8TF40-3 J3KNG8 FNIP1 Folliculin-interacting protein 1 1 LETVVCT(0.222)GS(0.778)VPVDK 112.02 0.0037457 4167100.0 2015.6 2081.1 2195.0 2057.3 1703.8 1929.5 1927.5 1725.3 1044.9 1654.1 True False 2062.559558325128 1837.4438445228577 1896.9310562719459 1698.031175303914 1549.6915908303208 1910.090981845829 1782.107123160847 1679.53943943578 1773.1189835234886 1866.4198472984096 1.105088740516034 0.9844750885940835 1.016347452057853 0.9097798535317585 0.8303017100217059 1.0233983444885844 0.9548264961607632 0.8998722564308701 0.950010784599204 1.0 10.866057838634957 -4.445231196771869 1.0794043063892127 0.937800588913127 1.2965712215381215 0.43427348982995384 0.05474720998789145 3.086949418265236 1.825801818811957 0.017491393212630886 1.506953103215442 3.587309133164293e-05 4.445231196771869 0.35877063262499453 LEVNGRES(ph)EEENLNK ddPTM_A459_Selumetinib_30min_R2 2 LEVNGRESEEENLNK 15 1 O95793-2;O95793-3;O95793;Q5JW30;A0A087X1A5;Q5JW28 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 LEVNGRES(1)EEENLNK;LEVNGRES(1)EEENLNK 129.88 0.0040141 17645700.0 53660.0 42583.0 51987.0 51179.0 55829.0 42168.0 48063.0 51779.0 47343.0 41234.0 True False 50677.792017999534 45848.97917407415 48642.21301916586 44208.33191130058 48815.261902407445 47976.2592370082 50298.02473502775 51929.668317525095 56812.922873943695 40043.46728120177 1.265569528785286 1.1449802498895432 1.2147352944633927 1.1040085914851332 1.219056820419833 1.1981045222707387 1.2560856526687423 1.2968324634041681 1.4187813076969555 1.0 15.289279279118524 -7.2253758829647365 2.6457684096728107 1.2698589522501282 1.185045302060233 0.031790894399925995 0.10603050301018485 0.6385635579660291 8.838454310294638 0.04550835757509027 0.031384297353508596 5.951468194871872e-08 7.2253758829647365 -0.08481365018989528 LEVPAERS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 LEVPAERSPR 10 1 Q9UJF2-2 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 LEVPAERS(1)PR;LEVPAERS(1)PR 108.68 0.005790399999999999 27702000.0 6139.3 6809.9 7897.0 9067.8 7383.7 5901.5 5792.4 5344.6 3399.6000000000004 4547.1 True False 6282.33374500172 6012.593742163383 6824.630775115975 7484.278953687272 6715.845638698114 5842.136268133273 5355.474604512006 5202.843846292512 5768.872903039957 5130.764577504745 1.2244439693346874 1.1718709076079845 1.3301391385287475 1.4587063663963933 1.3089366189481735 1.1386482813394823 1.0437965967085057 1.0140484459380168 1.1243690518042722 1.0 12.324958114389727 -6.9169365681091834 3.2227016234867794 1.0494583379060398 1.3025388249514447 0.712244497424063 0.07627074848929777 0.15476324248559242 3.2262978993428666 0.03268187421971641 0.02800340653455108 1.210774963190307e-07 6.9169365681091834 0.25308048704540487 LEVPAERS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 LEVPAERSPR 10 1 Q9UJF2-2 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 LEVPAERS(1)PR;LEVPAERS(1)PR;LEVPAERS(1)PR 80.102 0.026622000000000003 43311600.0 91866.0 82735.0 102884.0 101351.0 116250.0 75805.0 67757.0 76310.0 60342.0 102261.0 True False 86760.45548873539 89080.50846504532 96264.55545162922 87546.818959773 101645.63571181407 86246.45066072389 70907.83475794835 76532.04946619942 72412.08609635019 99308.45922401367 0.873646174421322 0.8970082625499527 0.969348998099767 0.8815645680524604 1.0235345156501559 0.8684703330878859 0.7140160597799529 0.7706498526330301 0.7291633226632551 1.0 16.599628993181646 -7.005681928770342 24.56123450173583 0.7853302683594422 0.9287617194934574 0.32078671193964736 0.08452327309052807 200.04759033446817 864747.4241897204 0.028647304691755995 0.024482185200241664 9.870020875690066e-08 7.005681928770342 0.14343145113401523 LEVS(ph)PEAQPTAR ddPTM_A459_Selumetinib_30min_R1 4 LEVSPEAQPTAR 12 0 Q6WKZ4 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 LEVS(0.984)PEAQPT(0.016)AR;LEVS(0.999)PEAQPT(0.001)AR;LEVS(1)PEAQPTAR;LEVS(1)PEAQPTAR 164.92 0.00044373 55114000.0 12035.300000000001 9256.7 11767.3 11696.9 11874.7 10838.4 10226.8 11416.400000000001 7164.799999999999 8998.2 True False 12315.699073382833 8172.9212606769215 10169.365293152103 9654.255993006544 10800.635481648562 10729.375536479833 9455.384242356085 11113.599986306528 12158.142303712399 10153.206619890307 1.2129861564381215 0.8049596119383632 1.0015914847266223 0.9508578279194762 1.063765949615359 1.0567474826584147 0.9312707400076765 1.094590152881829 1.1974682244616581 1.0 13.309647815729342 -7.896112882730296 7.292580895108915 1.1140189255504092 0.9981076402223021 0.13214823380402851 0.10859982835483532 0.3685101304111058 22.64325178524518 0.05676756250690426 0.027071680474068504 1.2702438978449812e-08 7.896112882730296 -0.11591128532810702 LEVS(ph)PEAQPTAR ddPTM_A459_Selumetinib_30min_R2 2 LEVSPEAQPTAR 12 0 Q6WKZ4 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 LEVS(1)PEAQPTAR;LEVS(0.953)PEAQPT(0.047)AR 169.58 0.00034175 49792000.0 66687.0 55078.0 61639.0 71629.0 62610.0 48964.0 63054.0 55623.0 57545.0 48999.0 True False 62980.80350921238 59302.305496316796 57673.21384746885 61873.006633082965 54744.372059498295 55708.346549062546 65986.13593913059 55784.85372111667 69055.60794164067 47584.27155530887 1.323563468571912 1.2462585547282707 1.2120226276960706 1.300282732313466 1.1504719998890176 1.1707302587223758 1.3867215737963454 1.1723380835256871 1.4512275944242399 1.0 15.538197165290052 -4.766321017707308 4.991127681977248 1.2390734445690532 1.3286537467741308 0.046768785347501396 0.1205907807004192 0.6282426971507383 41.095381212990375 0.027882230075253006 0.19672185640081116 1.712690868793383e-05 4.766321017707308 0.08958030220507762 LFAPVPFPS(ph)GSTEDVSPSGPQQPPPLPQK ddPTM_A459_Selumetinib_30min_R1 1 LFAPVPFPSGSTEDVSPSGPQQPPPLPQK 29 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 LFAPVPFPS(0.383)GS(0.383)T(0.118)EDVS(0.065)PS(0.051)GPQQPPPLPQK 47.803 0.023766 5171900.0 1597.5 2697.3 1724.4 1842.1 2150.6 2144.5 2152.0 1750.2 1112.3 1824.6 True False 1634.7186418061092 2381.498862059249 1490.2359514511825 1520.4118154996067 1956.0786097192695 2122.928277050209 1989.672907414859 1703.7790105491817 1887.4918608222579 2058.805183109049 0.7940132729496451 1.15673832648065 0.7238353408459673 0.7384923197072965 0.9501037911539305 1.031145780313379 0.9664211668683524 0.8275571795366602 0.9167899305420988 1.0 11.00759160435546 LFDDEAS(ph)VDEPR ddPTM_A459_Selumetinib_30min_R2 2 LFDDEASVDEPR 12 0 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35;Q8NI35-5 A0A0U1RR46 INADL InaD-like protein 1 LFDDEAS(1)VDEPR;LFDDEAS(1)VDEPR 149.57 0.00057257 5599100.0 47830.0 43944.0 49861.0 47695.0 52906.0 40226.0 47473.0 47477.0 36573.0 42345.0 True False 45171.80007866042 47314.36349776942 46652.99754455206 41198.85872153582 46259.475294359014 45766.76636472899 49680.5885659649 47615.15020975956 43888.62193500078 41122.389824477104 1.0984721527972336 1.1505742662262952 1.13449139857098 1.0018595440922842 1.1249218611031255 1.1129403363976533 1.2081153059930805 1.1578886930695307 1.0672682721585687 1.0 15.327636488627345 -8.538258228322015 4.822032432487312 1.0000855362134358 1.1230666662689404 0.38047256656581363 0.04975674623198089 0.18269485597136415 17.02853610791854 0.0512371114893064 0.013340552456268797 2.89562136046115e-09 8.538258228322015 0.1229811300555046 LFDDEAS(ph)VDEPRR ddPTM_A459_Selumetinib_30min_R1 2 LFDDEASVDEPRR 13 1 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35;Q8NI35-5 A0A0U1RR46 INADL InaD-like protein 1 LFDDEAS(1)VDEPRR;LFDDEAS(1)VDEPRR 115.04 0.0020956 5554800.0 2734.2 3005.4 2455.8999999999996 2581.2 2520.1000000000004 2483.5 3297.8999999999996 2923.8999999999996 1601.8899999999999 2722.3999999999996 True False 2797.9015401729334 2653.526370827445 2122.402269293062 2130.4418751249023 2292.1573999597917 2458.5182448375804 3049.136747845478 2846.3486738342754 2718.290332583444 3071.8465584216137 0.9108207350078581 0.8638212620199652 0.690920665771666 0.6935378556862466 0.7461822575986854 0.8003388834958033 0.9926071142733756 0.9265920740835426 0.8849043338870952 1.0 11.584890438568515 -7.1726171889423185 5.489307032967988 0.9444437727564996 0.7759888562815257 0.5691450327137867 0.07094938322449794 0.1883337157251604 9.038289478631476 0.03039096512609023 0.02334611819594534 6.720209481832445e-08 7.1726171889423185 -0.1684549164749739 LFDDEAS(ph)VDEPRR ddPTM_A459_Selumetinib_30min_R2 2 LFDDEASVDEPRR 13 1 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35;Q8NI35-5 A0A0U1RR46 INADL InaD-like protein 1 LFDDEAS(1)VDEPRR;LFDDEAS(1)VDEPRR 138.01 0.00051875 6710500.0 29425.0 20399.6 24666.0 29126.0 25971.0 24248.0 23387.0 27348.0 24996.0 19863.4 True False 27789.67629760782 21964.1837249476 23079.016414310223 25158.98855484751 22708.29079631416 27587.941898571775 24474.541840461356 27427.578152294867 29995.898446593917 19289.89203068882 1.4406341027412937 1.1386369446756972 1.196430564649775 1.304257614030259 1.1772119180442748 1.4301760660288485 1.2687754706726264 1.4218627096854444 1.5550060310795215 1.0 14.235557447911804 -6.759904146366248 24.99773713033201 1.3573811843811245 1.245046591330122 0.05735656004539469 0.15624767308930304 94.33645174303696 1536057.102545281 0.05046454178997953 0.047937235475451846 1.7381844230958267e-07 6.759904146366248 -0.11233459305100246 LFDDS(ph)DER ddPTM_A459_Selumetinib_30min_R2 2 LFDDSDER 8 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 LFDDS(1)DER;LFDDS(1)DER 108.43 0.012879 8342600.0 38882.0 20687.5 28136.0 39477.0 41820.0 45244.0 66690.0 66388.0 74848.0 25918.0 True False 36721.09409697834 22274.16472920319 26325.76039216054 34100.164498376565 36566.19772445647 51475.95031586038 69791.21714372796 66581.17808887489 89819.69142785508 25169.67999694881 1.4589416353894786 0.8849601874915919 1.0459314697426378 1.354811205486536 1.4527875494996043 2.0451571224624447 2.772828941495815 2.6452929912873815 3.56856707907067 1.0 14.619399253984385 -6.846206358020379 1.8606753202913124 2.640190449210989 1.1587448025392397 0.47973935949946767 0.6173078625070697 0.2586865826769511 1.8415868798695711 0.24937354842658557 0.21460061855205795 1.4249303672223294e-07 6.846206358020379 -1.4814456466717492 LFEDDDS(ph)NEK ddPTM_A459_Selumetinib_30min_R2 4 LFEDDDSNEK 10 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 LFEDDDS(1)NEK;LFEDDDS(1)NEK;LFEDDDS(1)NEK;LFEDDDS(1)NEK 155.39 0.00052627 16425400.0 98458.0 52619.9 77121.0 90663.0 94370.0 91724.0 168598.0 174991.0 142934.0 66568.0 True False 92986.09851860235 56655.67713035403 72159.11882299588 78314.54299760149 82514.39692149579 104358.14841242992 176438.14107059906 175500.19483868047 171524.7939096436 64646.00887556473 1.438388852397503 0.8763986844015218 1.1162192388689134 1.2114366278720614 1.276403576287678 1.6143014894129961 2.729296736790354 2.7147877787242183 2.653292862051342 1.0 15.980273683023958 -7.041865544168663 3.3089346290900163 2.412717543848597 1.1707762183334347 0.5103371769620837 0.49418027354989014 0.17391397177379078 3.8499633948483694 0.1876295984242636 0.14838965078233995 9.081016312882479e-08 7.041865544168663 -1.2419413255151623 LFEES(ph)DDKEDEDADGKEVEDADEK ddPTM_A459_Selumetinib_30min_R2 1 LFEESDDKEDEDADGKEVEDADEK 24 2 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 LFEES(1)DDKEDEDADGKEVEDADEK 70.027 0.0017875 5275800.0 13688.0 7576.2 6742.2 4217.7 6060.9 9327.4 19064.0 14676.0 8745.2 5874.7 True False 12927.275757405474 8157.270178677425 6308.414192352317 3643.241984061675 5299.475556866527 10612.16468429307 19950.513774599345 14718.704730257412 10494.484361303934 5705.082146696317 2.2659228079461333 1.4298251925085976 1.1057534370482949 0.6385958852794772 0.928904338377552 1.8601247819785263 3.4969722190857904 2.5799286236010954 1.8394975026575298 1.0 12.478031944493866 -6.995327055925961 10.83182901618996 2.4061516271553374 1.2530264436961294 0.2746990317938032 0.7127379073644557 0.1782151717701486 346.5693464424701 0.25831771356380034 0.22220788046540368 1.010817946744895e-07 6.995327055925961 -1.153125183459208 LFGGFNSSDTVTS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 LFGGFNSSDTVTSPQR 16 0 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 LFGGFNSSDTVT(0.047)S(0.952)PQR;LFGGFNSSDT(0.001)VT(0.026)S(0.973)PQR 152.07 0.00018278 20548700.0 4340.6 5137.5 5409.2 5912.0 5123.0 4066.5 5207.200000000001 4587.5 2575.0 4377.7 True False 4441.7275346626575 4535.999111641045 4674.660350608752 4879.580181984513 4659.625554539114 4025.5947020865824 4814.416711659228 4465.8245976999015 4369.58692944108 4939.620437409012 0.8992042184100454 0.9182889999581264 0.9463602335123465 0.9878451682299719 0.9433165186641822 0.8149603300690316 0.97465316873305 0.9040825412169459 0.8845997349004953 1.0 12.27018447341418 LFGGFNSSDTVTS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 4 LFGGFNSSDTVTSPQR 16 0 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 LFGGFNSSDTVT(0.006)S(0.994)PQR;LFGGFNSSDTVT(0.001)S(0.999)PQR;LFGGFNSSDT(0.095)VT(0.023)S(0.881)PQR;LFGGFNS(0.055)S(0.21)DT(0.174)VT(0.139)S(0.423)PQR 269.05 2.1122999999999996e-50 65490000.0 307695.0 278666.0 323866.0 342312.0 351016.0 251001.0 332253.0 283752.0 259969.0 304370.0 True False 290594.54370067746 300038.78614758333 303028.8141586393 295688.5150788624 306918.2319571449 285574.10938978114 347703.42284682987 284577.6713423275 311970.06414076587 295582.04725176725 0.9831265004168485 1.0150778402722813 1.0251935696910885 1.0003601972044143 1.0383520745281323 0.9661415909557536 1.1763347134227922 0.9627704861923952 1.055443207871958 1.0 18.173199121703746 LFIGGLSFETTEESLR ddPTM_A459_Selumetinib_30min_R1 2 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 232.78 2.2842e-14 15904300.0 1239.7 1472.65 1507.6 1448.3400000000001 1766.1999999999998 1571.08 1413.45 1484.06 1080.67 1493.63 False True 1268.5825979637143 1300.2314533835895 1302.8762006540264 1195.4146077089729 1606.4475218479356 1555.2763616265051 1306.8323285248773 1444.6979078937368 1833.8180609860551 1685.351959688244 0.7527107858220762 0.771489566858252 0.7730588220249449 0.7092967144560715 0.9531822196623522 0.922819920602341 0.7754061820811688 0.8572084303156337 1.088092045370318 1.0 10.71883419207701 -7.16081352522455 0.36538004699618715 1.0265546362926778 0.7183080826730107 0.5383170410235225 0.08069245489076383 1.2640973432386 0.40242911403394316 0.10107173873950502 0.1405075079165986 6.905362385282479e-08 7.16081352522455 -0.30824655361966713 LFLINEQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LFLINEQSPR 10 0 E9PFF8;Q6NW34-2;Q6NW34 E9PFF8 C3orf17 Uncharacterized protein C3orf17 1 LFLINEQS(1)PR 99.732 0.015305 0.0 6143.9 5680.3 7232.3 7933.4 5189.3 5447.5 5223.5 8052.2 3857.9 5725.8 True False 5802.446633980382 6115.960744956755 6766.981691932851 6852.857234121657 4537.373741069387 6197.84367751855 5466.403100168889 8075.630568886531 4629.587798732385 5560.481276584982 1.0435151824742777 1.0998977320022423 1.216977695874709 1.2324216004429025 0.8160037801361062 1.1146236034671102 0.9830809291972166 1.4523258270633455 0.8325876068007707 1.0 12.440994042663597 LFPADT(ph)SPSTATK ddPTM_A459_Selumetinib_30min_R1 2 LFPADTSPSTATK 13 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 LFPADT(0.5)S(0.5)PSTATK;LFPADT(0.571)S(0.425)PS(0.001)T(0.003)ATK 186.51 0.00031278 313920000.0 7528.2 8664.7 9408.3 10072.1 8428.8 6928.1 7717.6 7689.2 3676.0 5887.0 True False 7703.592412672769 7650.232895890252 8130.70453609264 8313.19681173312 7666.416528225508 6858.409604211498 7135.455218524597 7485.257437958384 6237.903515582684 6642.653794235981 1.1597160790401864 1.1516832177116585 1.2240144960057806 1.2514872924653573 1.154119538019259 1.0324803635201845 1.0741874316430933 1.1268474422757895 0.9390679852976065 1.0 12.697544009803616 -6.653513568826425 4.125012867676256 1.0448527508083798 1.196232059943662 0.6780874213839243 0.05323903498060768 0.14326679905926434 4.429525013708918 0.018470285015433827 0.018296148964250577 2.2206823007515518e-07 6.653513568826425 0.1513793091352822 LFPADT(ph)SPSTATK ddPTM_A459_Selumetinib_30min_R2 3 LFPADTSPSTATK 13 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 LFPADT(0.483)S(0.483)PS(0.026)T(0.007)ATK;LFPADT(0.492)S(0.492)PS(0.015)T(0.001)ATK;LFPADT(0.885)S(0.099)PS(0.015)T(0.001)ATK 165.51 0.00083346 46548800.0 126393.0 129010.0 139789.0 142240.0 141745.0 105324.0 126760.0 130247.0 95512.0 114856.0 True False 119368.58305126752 138904.65216746827 130795.12793075519 122866.66662231383 123937.7258836221 119831.42496392172 132654.59117017474 130625.9972064484 114617.06882825575 111539.80884827334 1.0701881622698814 1.2453370110793276 1.1726318099457629 1.101549912008979 1.111152396291207 1.074337729293829 1.189302658305822 1.1711154838371458 1.0275888941514 1.0 16.767199178106587 -8.349846615833126 4.907816851745846 1.0042385983052198 1.1432519347222416 0.49244747934189426 0.05219932834141364 0.19308319628890228 7.48630887512541 0.05128930642616942 0.013482492955274598 4.4684137976706795e-09 8.349846615833126 0.13901333641702185 LFPADTS(ph)PSTATK ddPTM_A459_Selumetinib_30min_R1 2 LFPADTSPSTATK 13 0 Q6NZY4;Q6NZY4-2 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 1 LFPADT(0.147)S(0.853)PS(0.001)TATK;LFPADT(0.22)S(0.755)PS(0.023)T(0.002)ATK 167.22 0.00031163 33267000.0 7336.7 7905.4 9447.6 10359.5 7539.5 7440.299999999999 7959.3 7344.299999999999 4130.5 6816.200000000001 True False 7507.630835266907 6979.832092879249 8164.6678119520975 8550.407796899282 6857.553556206835 7365.457337251886 7358.923592930808 7149.505306351477 7009.156820216065 7691.1256654104545 0.9761420059785546 0.9075176244057318 1.0615699401026977 1.1117238449702238 0.8916189715957353 0.9576566107061276 0.9568070934045884 0.9295785321133389 0.9113304248477658 1.0 12.908979049696608 -6.29643550121527 24.99954836163705 0.9392508635590575 1.009996379318537 0.2835958339220077 0.056688350523688355 892.6648331997261 637674.4209417045 0.018738284919966364 0.021240414696774554 5.053176860883217e-07 6.29643550121527 0.0707455157594794 LFPDT(ph)PLALDANK ddPTM_A459_Selumetinib_30min_R1 2 LFPDTPLALDANK 13 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 LFPDT(1)PLALDANK;LFPDT(1)PLALDANK 148.52 0.0012725999999999998 69527000.0 7687.9 7965.200000000001 8922.4 9369.7 7715.9 6972.4 7769.9 8071.3 4092.14 6737.099999999999 True False 7867.013111950663 7032.630681078984 7710.787087234999 7733.457786052144 7017.998207352787 6902.263986432674 7183.810187417619 7857.222904722667 6944.062701919621 7601.8724099112 1.0348783415114646 0.9251182211253576 1.014327348770258 1.0173096007201312 0.9231933698601457 0.9079689337371162 0.9450053618436798 1.0335904736415393 0.9134674100641393 1.0 12.892139095821829 -4.738548412265736 24.664174176772807 0.9650417926731704 1.0348786799484284 0.17700423031609158 0.04554762177257476 3175.988972853163 3421801.468090463 0.011540072783993471 0.6304870754980111 1.825793210424219e-05 4.738548412265736 0.06983688727525805 LFPDT(ph)PLALDANK ddPTM_A459_Selumetinib_30min_R2 3 LFPDTPLALDANK 13 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 LFPDT(1)PLALDANK;LFPDT(1)PLALDANK;LFPDT(1)PLALDANK 131.08 0.0034369 12466000.0 36968.799999999996 32960.7 39613.0 44476.8 38309.3 34406.8 35073.3 36838.2 30430.6 37432.8 True False 34914.22209383194 35488.679704645205 37064.34270737331 38418.9831132405 33496.54324451267 39146.02438616712 36704.27794642546 36945.39306310767 36517.57030200517 36352.017801905466 0.9604479807446022 0.9762506141484392 1.019595195770137 1.0568597133341713 0.9214493519189706 1.076859738556664 1.00969025011045 1.0163230350633 1.0045541488508798 1.0 15.14974782600541 -5.1433880167439465 3.9743655361984267 1.0141299920096105 0.9639141645218731 0.18275598551288064 0.03838336128466344 0.3685744967802979 9.868260273305498 0.009533636542193346 0.02940158636018161 7.188064794391401e-06 5.1433880167439465 -0.05021582748773745 LFPDT(ph)PLALDANKK ddPTM_A459_Selumetinib_30min_R1 2 LFPDTPLALDANKK 14 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 LFPDT(1)PLALDANKK;LFPDT(1)PLALDANKK 104.16 0.0079638 68509000.0 9636.3 10782.3 13082.7 13089.9 11710.2 9341.9 11082.699999999999 11533.0 6404.0 8685.4 True False 9860.807041024224 9519.903303444724 11306.141198127101 10803.994692855053 10651.014477603734 9247.928967766547 10246.723016267035 11227.10737553634 10867.12027034589 9800.25569296029 1.006178547780894 0.9713933596939772 1.1536577771382555 1.1024196746841786 1.0868098559157553 0.9436416005359441 1.0455567015080485 1.1455933117746084 1.1088608920838614 1.0 13.25860367492601 -7.642626647623189 24.998474209503208 1.0954618238283789 1.0456459514416068 0.06339696006102913 0.06772441847044355 17.16694291793765 3596.5441293682265 0.03357047488304717 0.019381921703298385 2.2770541174976687e-08 7.642626647623189 -0.0498158723867721 LFPDT(ph)PLALDANKK ddPTM_A459_Selumetinib_30min_R2 1 LFPDTPLALDANKK 14 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 LFPDT(1)PLALDANKK 101.01 0.014508000000000004 0.0 26838.0 22594.0 24626.0 30682.0 25715.0 22838.0 22106.0 22883.0 18699.0 26002.0 True False 25346.451401026316 24326.8871488395 23041.589970761495 26503.05867059779 22484.451804983204 25983.727197277414 23133.972802207994 22949.585741515424 22439.32249371339 25251.254698690595 1.003769979094966 0.9633932031940169 0.9124928739464309 1.0495739315469386 0.8904290924660127 1.0290073704188964 0.9161514181474558 0.9088493231469198 0.8886418818181332 1.0 14.62406745464581 -7.380581936070297 19.002470973020376 0.9208013133652929 0.971148134621725 0.14736639373565152 0.05296290258963031 5.779880481682405 900.6086195768595 0.02073523990121832 0.013979555943012527 4.163111703626366e-08 7.380581936070297 0.050346821256432084 LFPEFDDS(ph)DYDEVPEEGPGAPAR ddPTM_A459_Selumetinib_30min_R1 2 LFPEFDDSDYDEVPEEGPGAPAR 23 0 Q96P48-3;Q96P48 Q96P48-3 ARAP1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 1 LFPEFDDS(0.997)DY(0.003)DEVPEEGPGAPAR;LFPEFDDS(1)DYDEVPEEGPGAPAR 102.06 2.4781e-05 3391300.0 681.97 865.5899999999999 1096.45 1025.35 1005.48 686.76 784.86 856.1800000000001 359.87 674.14 True False 697.8585741173782 764.2463203981266 947.5581123687364 846.291870703285 914.534511531912 679.8518179281891 725.6573783055893 833.4713251354123 610.6731061351303 760.6724356796748 0.9174232447292885 1.0046983228927686 1.2456848282165973 1.1125575622404507 1.202271133585587 0.8937510892198021 0.9539682842026491 1.095703335681791 0.8028069343533957 1.0 9.571131517147144 -6.771246963036491 24.9979679146632 0.955522533201129 1.1006025616657866 0.30479969006224084 0.11092777193575745 277.6591182676387 707704.5617218894 0.03995282196801551 0.035668230410890386 1.6933745833798944e-07 6.771246963036491 0.14508002846465762 LFPSPGLPTRTS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 LFPSPGLPTRTSPVR 15 1 M0QYT1;M0R2C2;A0A384DVU0;Q8IY17-5;Q8IY17-2;Q8IY17-3;Q8IY17 M0QYT1 PNPLA6 Neuropathy target esterase 1 LFPSPGLPT(0.132)RT(0.132)S(0.736)PVR 66.285 0.034981 3051000.0 14767.0 12567.0 13858.0 13646.0 11052.0 8506.3 11939.0 13410.0 8713.3 13423.0 True False 13946.3092569847 13530.848490726119 12966.391367449558 11787.391259336995 9663.5489538664 9677.96561249675 12494.187156679698 13449.020879854988 10456.203469943459 13035.443112857616 1.0698761166951543 1.0380044908009192 0.9947027696097306 0.9042570442204918 0.7413287657505621 0.7424347242136179 0.9584781313920931 1.0317271736309015 0.8021364045254354 1.0 13.670152004682732 -5.665626145118463 2.7610721751156073 0.8742417182905999 1.0491130270902986 0.362120714056139 0.09424226587401077 0.30862303840474414 4.730465718709949 0.029368700976118996 0.056632540004073834 2.1596026657583e-06 5.665626145118463 0.1748713087996987 LFQDEEIY(ph)SDLYLT(ph)VCEWPS(ph)DASK ddPTM_A459_Selumetinib_30min_R2 1 LFQDEEIYSDLYLTVCEWPSDASK 24 0 Q66K64 Q66K64 DCAF15 DDB1- and CUL4-associated factor 15 3 LFQDEEIY(0.692)S(0.312)DLY(0.463)LT(0.52)VCEWPS(0.507)DAS(0.507)K 40.158 0.034029000000000004 21616000.0 7126.2 6947.9 8719.3 7913.3 6428.5 7010.2 6672.5 6461.6 5456.3 6407.8 True False 6730.15433243884 7480.781588980345 8158.309730856036 6835.494888796094 5620.8943584808285 7975.79141774035 6982.7844713079185 6480.4021862245345 6547.7124617598965 6222.790164536176 1.081533227778456 1.2021587408833887 1.3110372542128177 1.0984614149054448 0.9032755741169667 1.2817066310856131 1.1221307944952037 1.0413981533808572 1.0522148889216063 1.0 12.603345883340037 -7.67081703179835 0.3244146427937322 0.9867064556496064 1.1917467571375635 0.1757428719056109 0.10832403088085966 2.6955244483183582 0.8937014767461215 0.17603846680421614 0.19319374276486745 2.133943753983692e-08 7.67081703179835 0.20504030148795716 LFQECCPHSTDR ddPTM_A459_Selumetinib_30min_R1 4 LFQECCPHSTDR 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;;; 137.4 0.0038612 25171500.0 4184.349999999999 5189.4 5815.2 6528.900000000001 6215.200000000001 4967.77 5134.65 4764.32 2415.8199999999997 3849.33 False True 4281.837213672235 4581.82263551339 5025.527780607118 5388.750177631711 5653.036257382687 4917.79874417427 4747.339216569569 4637.9547569075985 4099.470095488287 4343.429001149379 0.985819547767249 1.0548860437918812 1.1570415400544682 1.2406672645519738 1.301514599613981 1.1322387779040244 1.0929933965337768 1.0678095015897073 0.9438326479846836 1.0 12.084618739702208 -7.8654219210336676 1.7757952490124425 0.9747670244946337 1.1507942190373752 0.3798542636057197 0.0845155680802204 0.43403413657538337 2.5631572411125423 0.07664012979457714 0.028072776060697833 1.3632580754365343e-08 7.8654219210336676 0.17602719454274152 LFQECCPHSTDR ddPTM_A459_Selumetinib_30min_R2 2 LFQECCPHSTDR 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 163.71 0.0007072999999999999 36846000.0 92301.0 102490.0 112812.0 146502.0 150128.0 106789.0 85351.0 81644.0 88515.0 148747.0 False True 87171.27993017851 110350.65344270873 105553.79874041844 126548.17486995352 131267.5784786513 121498.21541597591 89319.99061979794 81881.57052310827 106220.47331574079 144452.2876188804 0.6034607091870308 0.7639245820312335 0.7307173910523949 0.8760551802671019 0.908726200480706 0.841095820763559 0.6183355908869907 0.5668416324367443 0.735332579820338 1.0 17.14023352576254 -11.92668122974171 2.1150116211057055 2.841526382157603 0.7423283911182241 0.33619888986349256 0.110195417032029 6411180.9469865095 601424.2008558138 56490469.086698174 0.030731234936286194 1.183910221834288e-12 11.92668122974171 -2.0991979910393788 LFQLGPPS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 LFQLGPPSPVK 11 0 Q9NZH5-2;Q9NZH5;O95997 Q9NZH5-2 PTTG2;PTTG1 Securin-2;Securin 1 LFQLGPPS(1)PVK;LFQLGPPS(1)PVK 152.0 0.00058593 266790000.0 14307.2 17707.9 11688.0 12002.4 11498.900000000001 12669.3 13897.1 14272.900000000001 8711.2 14256.7 True False 14640.529923034968 15634.650835820632 10100.833797588384 9906.406152951777 10458.826525295684 12541.858344804017 12848.830558380607 13894.336327086865 14782.270159125093 16086.686317017873 0.9101022817574905 0.9719000251332657 0.6279002150307896 0.6158139692493371 0.6501541908125257 0.7796421275111312 0.798724504548088 0.8637164953224858 0.9189133092927375 1.0 13.973579556676627 -8.097592221361122 1.249072048131083 0.9899631504214473 0.7526468327463938 0.35367167142199785 0.10917440544529165 0.564155393369601 1.6219812104107765 0.11437421480592755 0.03812311165428276 7.987443122749389e-09 8.097592221361122 -0.23731631767505357 LFQLGPPS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 LFQLGPPSPVK 11 0 Q9NZH5-2;Q9NZH5;O95997 Q9NZH5-2 PTTG2;PTTG1 Securin-2;Securin 1 LFQLGPPS(1)PVK;LFQLGPPS(1)PVK 128.35 0.0027922 164235000.0 211615.0 171425.0 180855.0 226977.0 222574.0 181551.0 224294.0 219668.0 188191.0 187510.0 True False 199854.28546196385 184572.74628174765 169218.98620003535 196062.34104283515 194612.2642831937 206558.00229411092 234724.11543012917 220307.19751200484 225834.4584958775 182096.0990905109 1.0975209598676041 1.0136007701626037 0.929283971733656 1.076697095775689 1.0687338457836026 1.1343351303283067 1.289012321529521 1.2098402909910833 1.240193829652696 1.0 17.474340491298214 -6.756534765433383 2.1033188825992166 1.2026918654498597 1.0234877061363923 0.41274975178330564 0.08268070256003535 0.26738051394554324 2.4335683849118444 0.031771548308138095 0.02932995132773529 1.7517222025877387e-07 6.756534765433383 -0.17920415931346745 LFRPPS(ph)PAPAAPGAR ddPTM_A459_Selumetinib_30min_R1 2 LFRPPSPAPAAPGAR 15 1 Q86U90 Q86U90 YRDC YrdC domain-containing protein, mitochondrial 1 LFRPPS(1)PAPAAPGAR;LFRPPS(1)PAPAAPGAR 88.19 0.0098342 429960000.0 5808.5 6034.2 7402.9 7741.2 6224.200000000001 5999.1 5644.6 5520.9 3206.6 4448.8 True False 5943.82674862647 5327.713058776525 6397.626841218948 6389.344740321126 5661.222208971764 5938.754500746983 5218.823277506466 5374.4677975894065 5441.365999202239 5019.846814981666 1.1840653644822783 1.0613298084865928 1.2744665478885364 1.2728166766468274 1.1277679215381478 1.1830549257046745 1.0396379550728436 1.0706437856926985 1.0839705273401081 1.0 12.293427624408205 -7.257018383473199 23.943079744838066 1.0544500444197087 1.183949312898087 0.5317202486352262 0.062130013802487935 187.0027346118692 1012768.117946122 0.02558176365484681 0.019091372717656672 5.53326686671746e-08 7.257018383473199 0.12949926847837823 LFRPPS(ph)PAPAAPGAR ddPTM_A459_Selumetinib_30min_R2 1 LFRPPSPAPAAPGAR 15 1 Q86U90 Q86U90 YRDC YrdC domain-containing protein, mitochondrial 1 LFRPPS(1)PAPAAPGAR 110.26 0.0019492 190720000.0 34912.0 33943.0 30396.0 37600.0 42950.0 34264.0 31016.0 29320.0 25213.0 33319.0 True False 32971.73080380915 36546.31895605286 28440.354452662505 32478.815136382178 37554.237022128276 38983.55498237643 32458.305457038066 29405.31634581271 30256.304510080503 32356.993896841457 1.018998579068487 1.129472010674649 0.8789553981230229 1.003764912152504 1.1606219397839102 1.2047953251362398 1.0031310560097024 0.9087777572774807 0.9350777333191631 1.0 14.981789961001802 -7.521816136180101 23.783317690888076 0.9443474558479462 1.0654402077061262 0.26735435165627164 0.08818450584400184 31.576259583868488 706847.8429207499 0.04439305961234134 0.026095550733038163 3.0073492308126914e-08 7.521816136180101 0.12109275185818003 LFS(ph)LSNPSLSTTNLSGPSR ddPTM_A459_Selumetinib_30min_R2 1 LFSLSNPSLSTTNLSGPSR 19 0 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 LFS(0.499)LS(0.499)NPS(0.001)LS(0.001)TTNLSGPSR 173.09 1.6938e-09 10262000.0 50918.0 46473.0 52073.0 57025.0 64339.0 48269.0 41846.0 50416.0 41498.0 43364.0 True False 48088.181400903864 50037.32966575277 48722.6798727956 49258.096626388084 56256.15962204216 54917.61660764441 43791.92191627591 50562.70221318189 49798.75955099837 42111.96864679713 1.1419124525911057 1.1881973527627616 1.1569793918076838 1.1696935149132348 1.335871046397181 1.3040857117901854 1.0398925370497147 1.2006729639562335 1.1825322147409478 1.0 15.36194269962033 -9.645364860726435 0.6412033992684951 0.9879219103759238 1.1996029041429148 0.355375255847577 0.07770517270194496 7.01938685720117 2.9634338954240547 0.3023830077169613 0.032225113511767094 2.262742527094999e-10 9.645364860726435 0.211680993766991 LFS(ph)PAHK ddPTM_A459_Selumetinib_30min_R2 2 LFSPAHK 7 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 LFS(1)PAHK;LFS(1)PAHK 76.679 0.034334 16511100.0 202448.0 189467.0 183548.0 228400.0 217085.0 178608.0 186985.0 178072.0 141945.0 225456.0 True False 191196.75062355518 203998.50966757382 171738.72151195235 197291.5259880235 189812.8415354764 203209.63075800505 195680.1730037486 178590.16003859355 170337.96627467513 218946.49947496285 0.8732578556042138 0.9317276602127252 0.7843866968587508 0.9010946804864736 0.8669370918952829 0.9281245932011013 0.8937351063981052 0.8156794489377795 0.7779889912976378 1.0 17.740218858548076 -10.625057845533007 4.757605958939212 1.0000071773118697 0.8658965191952395 0.38046919195868134 0.052123488591171406 4.061742949642181e-06 7.665692540319579e-07 0.05165915383700168 0.012528514717753087 2.3710578733250014e-11 10.625057845533007 -0.13411065811663025 LFS(ph)QGQDVSNK ddPTM_A459_Selumetinib_30min_R1 1 LFSQGQDVSNK 11 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;H0Y8L4;H0Y948;H0Y8U8 A8MQ02 MLLT4 Afadin 1 LFS(1)QGQDVSNK 131.96 0.0021034 9874700.0 1885.2 2637.1 2332.8 2278.4 1502.7 2373.4 2080.5 2167.6 1429.4 1923.2 True False 1929.121492039359 2328.347106045471 2016.018573153165 1880.520210864938 1366.7810503232329 2349.5257508747814 1923.5662099798403 2110.1082066429008 2425.587400754594 2170.0614535543814 0.8889709039712297 1.072940631350246 0.9290145077924375 0.8665746344578404 0.6298351818952217 1.0827000991268945 0.8864109386530035 0.9723725580152202 1.1177505580690732 1.0 11.083520183314691 -8.023118017027702 4.6972404861555255 1.057736930412617 0.9102776736998116 0.19905710949873068 0.12048782821878463 0.3347377999154311 18.711387122322876 0.08312803586031363 0.03245458478334234 9.481607710529072e-09 8.023118017027702 -0.14745925671280535 LFS(ph)QGQDVSNK ddPTM_A459_Selumetinib_30min_R2 1 LFSQGQDVSNK 11 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;H0Y8L4;H0Y948;H0Y8U8 A8MQ02 MLLT4 Afadin 1 LFS(0.993)QGQDVS(0.007)NK 88.075 0.031157 2610600.0 22070.0 19168.0 15991.0 18427.0 14971.0 15422.0 13132.0 18385.0 15344.0 20841.0 True False 20843.43775321001 20638.123965165767 14962.156469684367 15917.210811651972 13090.209137561877 17546.24051302268 13742.66402056435 18438.49730619941 18413.228747181038 20239.266178578986 1.0298514565350434 1.0197071268823437 0.7392637824744924 0.7864519726756977 0.6467729127163913 0.8669405480517582 0.6790099946958271 0.9110259800681167 0.9097774882109804 1.0 14.304869362283391 -5.249404835168672 23.560787708230805 0.8038546253853547 1.0247793997555723 0.37983039769532667 0.1048548188437244 329.05710313697443 644208.2210145723 0.026224031244588285 0.06805293428695304 5.63112495970452e-06 5.249404835168672 0.22092477437021762 LFSLS(ph)NPSLSTTNLSGPSR ddPTM_A459_Selumetinib_30min_R1 2 LFSLSNPSLSTTNLSGPSR 19 0 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 LFS(0.031)LS(0.959)NPS(0.004)LS(0.005)TTNLSGPSR;LFS(0.001)LS(0.998)NPS(0.001)LSTTNLSGPSR 227.64 1.6856999999999998e-23 46117000.0 4244.1 4288.4 4411.2 4835.1 4971.2 3507.8 4623.6 4186.299999999999 2299.1 4431.9 True False 4342.979272418973 3786.312134376926 3812.183268987156 3990.7405510678846 4521.555837736646 3472.5147168275703 4274.838129518282 4075.2657249811687 3901.4047803797994 5000.777535361724 0.8684608026869225 0.7571446855219982 0.76231810794027 0.7980240118358354 0.9041705626302342 0.6943949600382274 0.8548346930631993 0.8149264181747669 0.7801596357350451 1.0 12.287936711389403 -10.953457678568384 3.1292388602978525 1.0032567928421945 0.8026210312330464 0.5085704387026544 0.05784101063408295 43345284.35312097 56857794.29199973 1261685.012530452 0.013538533005661154 1.1131208596947234e-11 10.953457678568384 -0.2006357616091481 LFSLS(ph)NPSLSTTNLSGPSR ddPTM_A459_Selumetinib_30min_R2 1 LFSLSNPSLSTTNLSGPSR 19 0 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 LFS(0.01)LS(0.715)NPS(0.224)LS(0.038)T(0.01)T(0.003)NLSGPSR 131.48 0.0002664 11241000.0 15107.0 14514.0 17104.0 22101.0 22014.0 13911.0 11889.0 17395.0 14522.0 14753.0 True False 14267.413418112545 15627.177130134382 16003.547261427133 19090.80567364847 19248.404512343004 15827.11397851501 12441.862057606577 17445.616570102724 17426.805778582053 14327.042557102615 0.9958380008468315 1.0907468912617437 1.1170168021517737 1.3325014983070755 1.3435015939699733 1.1047020985268683 0.868418028914037 1.217670464826956 1.216357507777677 1.0 13.80645321325666 -4.95063286671989 2.2230124044801496 1.1593122342741549 0.985538787895916 0.10753351013848711 0.13604724501330978 1.0649306973808388 8.097080852241511 0.03961386549830489 0.3216711408962054 1.1203846066733672e-05 4.95063286671989 -0.17377344637823888 LFT(ph)SPLCDVSK ddPTM_A459_Selumetinib_30min_R1 1 LFTSPLCDVSK 11 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 LFT(0.715)S(0.285)PLCDVSK 119.27 0.0073897999999999985 0.0 1314.5 2060.5 1524.3 1526.1 1390.8 1270.7 1292.6 1181.3 823.91 1399.6 True False 1345.1252924282508 1819.2557020995391 1317.308432380559 1259.5952834449542 1265.002385565684 1257.9179117032877 1195.09814132177 1149.9680865968173 1398.1150939944853 1579.2522932584814 0.8517481963903596 1.1519728100858775 0.8341342532816894 0.7975896497487576 0.8010134865503957 0.7965275194299815 0.7567493467784786 0.7281724975203808 0.8853019241844794 1.0 10.625025951843355 -5.428849487847724 8.605807019349006 0.8080699583074915 1.0013709752233668 0.3327786807644919 0.09858600439589607 0.3058606447021423 25.640732286123583 0.023793790854110007 0.04963767792582041 3.725207873115632e-06 5.428849487847724 0.1933010169158753 LFT(ph)VQFS(ph)SAYSEIERY(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LFTVQFSSAYSEIERYPR 18 1 K7EMN7 K7EMN7 AP2B1 3 LFT(0.993)VQFS(0.984)S(0.023)AY(0.002)S(0.001)EIERY(0.997)PR 73.593 0.037412 5812100.0 11760.0 10004.0 12602.0 14970.0 17332.0 9985.4 8918.2 12524.0 8228.0 12291.0 True False 11106.426279009966 10771.274632070033 11791.201040020158 12931.060175309605 15154.599209954076 11360.798211563784 9332.913971078053 12560.44276654019 9873.829909528517 11936.126894146846 0.9304882879936754 0.9024095276125101 0.9878582177106582 1.0833547841763183 1.2696412617216295 0.9517993828580034 0.7819047211750624 1.0523047281526048 0.8272222637286452 1.0 13.54304715777059 -6.986948218282597 24.998513807997465 0.9121645179978091 1.0358159564822582 0.18846540689566071 0.11817889103392146 407.97431953772167 781403.8454236963 0.04408981233718492 0.038862726105205594 1.0305089825687455e-07 6.986948218282597 0.12365143848444915 LFTS(ph)PLCDVSK ddPTM_A459_Selumetinib_30min_R2 1 LFTSPLCDVSK 11 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 LFT(0.059)S(0.937)PLCDVS(0.004)K 97.957 0.018725 2686000.0 17590.0 14916.0 17942.0 18122.0 16027.0 13907.0 19103.0 18255.0 15772.0 17170.0 True False 16612.418218349074 16060.009237500646 16787.631253772553 15653.75233780632 14013.544976802103 15822.563014823394 19991.327351876385 18308.119027722063 18926.84070650021 16674.257486982446 0.9962913329914901 0.9631618829227423 1.0067993292582065 0.9387975656503547 0.8404299254549982 0.9489215952899871 1.198933587746475 1.097987064312469 1.135093464957966 1.0 14.02533489845863 -7.241523261931464 24.00394775646509 1.1161691085782752 0.9469269560280112 0.6090274889923184 0.062234027185299634 314.6955252201686 379287.75763942883 0.0241761145345135 0.018694846533193657 5.7342515159476584e-08 7.241523261931464 -0.16924215255026398 LFVGGIKEDTEEHHLR ddPTM_A459_Selumetinib_30min_R1 2 LFVGGIKEDTEEHHLR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 101.43 0.0022796999999999995 44908000.0 9441.6 8898.2 17942.2 18183.5 13754.5 11455.6 8943.8 8192.6 5578.799999999999 6113.4 False True 9661.570909844486 7856.3946073390525 15505.747789449908 15008.09307156891 12510.407903554202 11340.367064852595 8269.161965305304 7975.305634684742 9466.816140569279 6898.114439558732 1.4006104123814058 1.1389191461198231 2.2478240866125443 2.1756804998046637 1.81359819602449 1.6439807086729097 1.1987568541751066 1.156157339018417 1.3723773682674458 1.0 12.751986347936693 -7.18956283083031 3.3951466228088742 1.1890132871422738 1.768974523320666 0.42717752620905747 0.31644963774936197 0.28036389067611833 6.328771089167204 0.14737326268646825 0.10800387667878988 6.463044842114844e-08 7.18956283083031 0.5799612361783921 LFVLLPEQS(ph)PVSYSK ddPTM_A459_Selumetinib_30min_R1 2 LFVLLPEQSPVSYSK 15 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 1 LFVLLPEQS(0.999)PVS(0.001)YSK;LFVLLPEQS(0.985)PVS(0.012)YS(0.004)K 247.5 7.0338999999999995e-28 106905000.0 12020.8 15027.8 12972.2 15220.1 13473.2 12890.5 13115.0 11709.4 6104.200000000001 10989.400000000001 True False 12300.861251594908 13268.338189765325 11210.646491194058 12562.195251661453 12254.551438886663 12760.833273637547 12125.72499105292 11398.828674508386 10358.381566871542 12399.996535820786 0.9920052167805451 1.070027572301016 0.904084647024621 1.0130805452543563 0.9882705534220139 1.0290997450502817 0.9778813208555698 0.9192606337896746 0.835353585539199 1.0 13.598052097116852 -7.729213915425617 3.7243793326377688 0.9057986428308185 0.9985735306436626 0.3048382245068949 0.054097632972849835 0.24041017916257013 6.997074069717777 0.028422514919155054 0.014283724410463938 1.865460616076975e-08 7.729213915425617 0.09277488781284415 LFVT(ph)PPEGSSR ddPTM_A459_Selumetinib_30min_R1 1 LFVTPPEGSSR 11 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LFVT(0.999)PPEGSSR 166.24 0.0014180999999999998 51432000.0 4632.3 4781.8 5800.1 5967.9 5680.2 4308.2 5062.1 4617.8 2503.7 4239.7 True False 4740.223577113262 4221.944633001489 5012.478277668756 4925.718296357475 5166.426912920764 4264.863419532622 4680.261721479908 4495.320943271632 4248.596036987042 4783.906793175182 0.9908687150585291 0.8825307046166952 1.0477792512219632 1.0296434502830623 1.079959776869251 0.8915021976634164 0.9783346381574289 0.9396756955392082 0.888101758806876 1.0 12.22397356585072 -6.779130276585913 24.999841841508573 0.9381783412643111 1.0029055357469692 0.24826003872887892 0.05781344465833838 394.5509547120295 557554.7677875586 0.02122496210027935 0.018758046471278666 1.6629137464450496e-07 6.779130276585913 0.06472719448265807 LGADES(ph)EEEGRR ddPTM_A459_Selumetinib_30min_R1 2 LGADESEEEGRR 12 1 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 LGADES(1)EEEGRR;LGADES(1)EEEGRR 155.86 0.00077199 33931000.0 9066.2 10913.3 10086.7 10211.3 9856.4 8907.8 9761.5 9189.099999999999 5117.9 7073.3 True False 9277.424820245727 9635.565762544475 8716.981542277106 8428.088144840744 8964.890360288755 8818.195619635273 9025.18219597126 8945.375217596556 8684.702503373395 7981.226954776524 1.1624058397053185 1.2072787576574149 1.0921856491075292 1.0559890343422431 1.1232471412084752 1.104867167617361 1.1308013476010679 1.120802010553405 1.0881412786007623 1.0 12.96239483380445 -14.522878745280336 0.09627057972742205 0.6394570183922675 1.2031277415354407 0.5400205693265157 0.03636707688927042 180.26652754933193 1.185897913025343 13.343441985340673 0.7777120852517871 3.0000000000000132e-15 14.522878745280336 0.5636707231431731 LGAES(ph)PSIASTSSTEK ddPTM_A459_Selumetinib_30min_R1 1 LGAESPSIASTSSTEK 16 0 Q99569-2;Q99569;A0A0D9SF60;H0YFB1;E7EST6 Q99569-2 PKP4 Plakophilin-4 1 LGAES(0.998)PS(0.002)IASTSSTEK 248.81 2.5584e-29 18437000.0 2794.7 2894.2 2854.4 2943.6 3296.6 2707.4 2427.4 2443.5 1220.0 1859.4 True False 2859.8110724604253 2555.3457185229217 2466.7881580968783 2429.555518215428 2998.4231120619997 2680.1660141225157 2244.299263689048 2378.6904423933984 2070.2508947254814 2098.0721020897568 1.3630661546912275 1.2179494288960344 1.1757404121811956 1.1579942919004078 1.4291325398566905 1.2774422821088809 1.0696959658601073 1.133750570356536 0.9867396323812874 1.0 11.03484854291088 -7.275689111187201 7.474221226886256 1.058121934978472 1.2657845042680596 0.6199602230955411 0.08521175854881563 0.13088434328823592 44.660862842450626 0.03676450335886488 0.025698551232574102 5.30042738122303e-08 7.275689111187201 0.20766256928958748 LGAES(ph)PSIASTSSTEK ddPTM_A459_Selumetinib_30min_R2 4 LGAESPSIASTSSTEK 16 0 Q99569-2;Q99569;A0A0D9SF60;H0YFB1;E7EST6 Q99569-2 PKP4 Plakophilin-4 1 LGAES(0.826)PS(0.096)IAS(0.075)T(0.001)S(0.001)S(0.001)TEK;LGAES(0.898)PS(0.102)IASTSSTEK;LGAES(0.809)PS(0.133)IAS(0.037)T(0.011)S(0.003)S(0.005)T(0.001)EK;LGAES(0.992)PS(0.007)IASTSSTEK 185.63 7.7289e-07 46560300.0 155627.0 120298.0 145045.0 142810.0 129681.0 111339.0 134967.0 110149.0 97179.0 117747.0 True False 146977.87436424175 129524.46978096364 135712.96261305548 123359.03163900902 113389.31341715052 126674.93661518823 141243.23293203698 110469.51535385138 116617.51540812722 114347.33816655325 1.2853633212708486 1.1327283333198719 1.1868484635416874 1.0788098229215421 0.9916218010426503 1.1078083551947588 1.2352122506455583 0.9660873364008387 1.0198533457619041 1.0 16.803063256814205 -1.5228787452803376 0.38258540034341565 1.0420594213192826 4.264433011029907 0.4614891265986344 0.07621474912062459 70.75485261801401 0.9626450877282009 0.06134648907994946 169.40699352658038 0.029999999999999995 1.5228787452803376 3.2223735897106245 LGAESPS(ph)IASTSSTEK ddPTM_A459_Selumetinib_30min_R1 1 LGAESPSIASTSSTEK 16 0 Q99569-2;Q99569;A0A0D9SF60;H0YFB1;E7EST6 Q99569-2 PKP4 Plakophilin-4 1 LGAES(0.458)PS(0.541)IASTSSTEK 238.12 2.5018000000000004e-21 22473000.0 4136.1 4303.4 4044.3 3553.1 3556.4 3506.5 3646.4 2850.9 1605.9 2840.8 True False 4232.463082550391 3799.555927403618 3495.1062737497177 2932.617784947426 3234.724247933419 3471.2277936472647 3371.349112266518 2775.2848709716973 2725.095009704634 3205.4443517352784 1.3203982406555062 1.1853445296427358 1.0903656062092077 0.9148865065649457 1.0091344266146096 1.0829162552044005 1.0517571800744028 0.8658034788435143 0.8501457865675922 1.0 11.646308647624478 -1.5228787472337353 0.48404356286741534 0.9481777905119632 12.091529367041714 0.71365136080013 0.07352232621996703 59.50563091256122 0.6599583190246054 0.04679752869151926 668.6503657288885 0.029999999865064065 1.5228787472337353 11.143351576529751 LGAGEGGEAS(ph)VSPEK ddPTM_A459_Selumetinib_30min_R1 1 LGAGEGGEASVSPEK 15 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LGAGEGGEAS(0.95)VS(0.05)PEK 155.37 0.00017250000000000002 290080000.0 9833.0 11711.0 7676.9 7348.4 7373.0 7801.5 9706.7 9215.5 5126.1 8885.1 True False 10062.089768312662 10339.870675703807 6634.419146193212 6065.1398865519295 6706.113451808873 7723.023993195249 8974.515804090996 8971.075003837272 8698.61730446909 10025.589133203015 1.003640747154575 1.0313479375950034 0.6617485574210462 0.6049659332702192 0.6688996888571253 0.7703311885800238 0.8951609411529696 0.8948177393512592 0.8676415110270952 1.0 13.291399395738617 -7.291624011496621 6.179228284375573 0.9065572336153965 0.7812815903332528 0.16763334622510462 0.13438001835128666 0.42750690369294964 54.84954362205881 0.06415269229880134 0.04394563350033329 5.10947158764492e-08 7.291624011496621 -0.1252756432821437 LGAGEGGEASVS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 3 LGAGEGGEASVSPEK 15 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LGAGEGGEASVS(1)PEK;LGAGEGGEAS(0.404)VS(0.596)PEK;LGAGEGGEAS(0.072)VS(0.928)PEK 244.0 1.6030000000000002e-20 815990000.0 21952.5 27909.4 17936.2 17776.6 17247.6 18563.1 21318.3 20238.199999999997 12404.199999999999 22480.399999999998 True False 22463.9505378708 24641.75447327194 15500.562556494258 14672.250518109935 15687.557625311108 18376.37206794626 19710.243467538192 19701.41719306163 21049.02143307689 25365.978317639318 0.8855936978488046 0.9714490079862697 0.6110768669117437 0.5784224181847131 0.6184487516652214 0.7244495693338768 0.7770346256990937 0.7766866685114765 0.829813113040452 1.0 14.630607183101038 -8.665191457532723 1.069197816858459 0.9988135864591519 0.7295459119011146 0.32086919242119505 0.11566240836434911 0.950008380662231 2.25366748180453 0.1250924306002969 0.04009858600152773 2.1617653053172777e-09 8.665191457532723 -0.26926767455803724 LGAGEGGEASVS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 6 LGAGEGGEASVSPEK 15 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LGAGEGGEAS(0.385)VS(0.615)PEK;LGAGEGGEAS(0.004)VS(0.996)PEK;LGAGEGGEAS(0.46)VS(0.54)PEK;LGAGEGGEAS(0.001)VS(0.999)PEK;LGAGEGGEAS(0.007)VS(0.993)PEK;LGAGEGGEAS(0.001)VS(0.999)PEK 202.01 1.3998e-05 1643921000.0 1490516.0 1106906.0 1237731.0 1249543.0 1200404.0 1070619.0 1461873.0 1316394.0 984776.0 1109122.0 True False 1407679.0877283004 1191802.1309362384 1158096.7349996187 1079353.087818094 1049598.51777208 1218087.0491383641 1529852.9911463961 1320224.488599243 1181758.7169404281 1077098.7660149669 1.3069173711306061 1.1064928941898702 1.0752001316316857 1.0020929573723938 0.9744682204542561 1.1308963370601783 1.4203460624196258 1.225722775158112 1.0971683881067662 1.0 20.038719115127307 -7.010337803526102 24.628594436762864 1.2147626306147308 1.0842332554298613 0.08247129403569975 0.13088038862943557 754.7964140061655 1798213.2853765895 0.04887918792806383 0.04048712021584318 9.764774005086773e-08 7.010337803526102 -0.1305293751848695 LGAGEGGEASVS(ph)PEKTSTTSK ddPTM_A459_Selumetinib_30min_R1 6 LGAGEGGEASVSPEKTSTTSK 21 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LGAGEGGEAS(0.009)VS(0.988)PEKT(0.003)STTSK;LGAGEGGEAS(0.004)VS(0.995)PEKTSTTSK;LGAGEGGEAS(0.014)VS(0.981)PEKT(0.003)S(0.001)TTSK;LGAGEGGEAS(0.241)VS(0.747)PEKT(0.011)S(0.002)TTSK;LGAGEGGEASVS(0.913)PEKT(0.072)S(0.01)T(0.004)T(0.001)SK;LGAGEGGEAS(0.001)VS(0.773)PEKT(0.163)S(0.036)T(0.02)T(0.006)S(0.002)K 126.27 3.6412e-05 1286262000.0 25235.4 31735.4 39747.100000000006 42097.7 28323.0 28485.399999999998 26128.3 25708.0 17040.6 23848.600000000002 True False 25823.3357204594 28019.804614612814 34349.66213519211 34746.12696669984 25761.18965083179 28198.862738673815 24157.421294984997 25026.140328647216 28916.6536038189 26909.80011503589 0.9596256980753481 1.0412490800686665 1.2764740722098187 1.2912071742697706 0.9573162766243547 1.0479030917408285 0.8977183476545781 0.9300009744280421 1.0745770492610116 1.0 14.715844054284098 -6.295669599330231 24.908346161769884 0.9799084570544269 1.1445279914616922 0.35592852848302614 0.10369446524744647 697.9376864484648 507867.2624779131 0.0348835386777699 0.03955611761650157 5.062096275102643e-07 6.295669599330231 0.1646195344072653 LGAGEGGEASVS(ph)PEKTSTTSK ddPTM_A459_Selumetinib_30min_R2 4 LGAGEGGEASVSPEKTSTTSK 21 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 LGAGEGGEAS(0.013)VS(0.977)PEKT(0.003)S(0.001)T(0.001)T(0.002)S(0.002)K;LGAGEGGEAS(0.011)VS(0.986)PEKT(0.001)ST(0.001)TSK;LGAGEGGEAS(0.154)VS(0.77)PEKT(0.035)S(0.014)T(0.018)T(0.007)S(0.003)K;LGAGEGGEAS(0.103)VS(0.694)PEKT(0.118)S(0.03)T(0.041)T(0.01)S(0.003)K 93.381 0.00028624 759133000.0 392076.0 439055.0 387315.0 403911.0 386691.0 241760.0 276989.0 267029.0 174205.0 414305.0 True False 370285.9855245846 472729.10671566514 362395.574576687 348897.6250146612 338111.41951859836 275060.2455212269 289869.5373432907 267806.0101809693 209050.86769438675 402342.9381563353 0.9203243064768429 1.174940733101622 0.9007131484332744 0.8671647789157733 0.840356291744385 0.6836462615241649 0.7204538960508816 0.6656162809968594 0.5195837875329067 1.0 18.618066185454317 -6.052695834181492 1.0473642883313734 0.6948795720658525 1.0472663139206313 0.4564214758029407 0.13174933714820788 0.4320426927600911 0.9711625519990681 0.05248702217154396 0.10256360720019073 8.857357333284569e-07 6.052695834181492 0.3523867418547788 LGAGGGS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 LGAGGGSPEK 10 0 Q9UNE7;H3BS86 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 LGAGGGS(1)PEK;LGAGGGS(1)PEK 101.35 0.016452 126705000.0 669180.0 527060.0 515570.0 602500.0 595670.0 496080.0 728760.0 710070.0 555210.0 535390.0 True False 631989.6545397858 567483.8072349901 482398.78751017165 520438.46062952816 520836.6092426339 564410.517034126 762648.7840105455 712136.1861415826 666267.5138635546 519931.899589722 1.2155239081089053 1.0914579537873927 0.9278114843325295 1.000974283440208 1.0017400541371395 1.0855470062127406 1.4668243756775672 1.3696720410952452 1.2814515023781115 1.0 18.98796314661717 -7.111656266243482 6.550411296659451 1.3092371045684572 1.0410359036263908 0.4070690432120777 0.13191796709884182 0.21328443570175104 11.004574606250657 0.05004311737692231 0.03873855125751171 7.732923854881272e-08 7.111656266243482 -0.26820120094206645 LGAGGGS(ph)PEKSPSAQELK ddPTM_A459_Selumetinib_30min_R2 1 LGAGGGSPEKSPSAQELK 18 1 Q9UNE7;H3BS86 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 LGAGGGS(0.961)PEKS(0.011)PS(0.028)AQELK 202.35 5.2792e-10 48843000.0 6803.0 3808.5 5218.8 6350.0 4695.2 4428.0 5152.5 6501.0 3284.2 4541.1 True False 6424.91649456673 4100.599703742374 4883.02808979981 5485.1190456390095 4105.347000379432 5037.916806618107 5392.10145948506 6519.916833701514 3941.131768215065 4409.986643805241 1.4569015766956763 0.9298440188027629 1.1072659588797293 1.2437949337882959 0.9309205065612296 1.1423882232602511 1.2227024467431 1.478443668953083 0.8936833796880582 1.0 12.106558571069572 -7.011580139136659 23.271215073133387 1.1877159460311162 1.1180197810381545 0.0 0.20214629646543553 1114.2581557125393 2239192.2424112866 0.0716502369915079 0.05887379662544832 9.736880968303309e-08 7.011580139136659 -0.06969616499296172 LGAGGGSPEKS(ph)PSAQELK ddPTM_A459_Selumetinib_30min_R2 2 LGAGGGSPEKSPSAQELK 18 1 Q9UNE7;H3BS86 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 LGAGGGS(0.361)PEKS(0.528)PS(0.112)AQELK;LGAGGGS(0.001)PEKS(0.843)PS(0.157)AQELK 73.983 0.0092412 265687000.0 136553.0 122199.0 122411.0 131032.0 113215.0 88086.0 104396.0 113489.0 74991.0 108518.0 True False 128963.93092496999 131571.27036828516 114535.20953101943 113185.21555719232 98991.91954505832 100219.04693490575 109250.62085674962 113819.23420088468 89991.2954236087 105384.80337637491 1.2237431469543456 1.2484842800188847 1.0868285166502085 1.074018377706307 0.9393377068941826 0.9509819606246264 1.0366828741575596 1.080034602279294 0.8539304770746754 1.0 16.685307317937486 -5.539740629873663 1.506987379475962 0.9845360525177576 1.2495876409040736 0.7204767534335303 0.06156246541346075 0.23666710715346687 1.01763799630419 0.01928167410189623 0.06028468383162646 2.885754424004878e-06 5.539740629873663 0.26505158838631604 LGAGGGSPEKSPS(ph)AQELK ddPTM_A459_Selumetinib_30min_R1 1 LGAGGGSPEKSPSAQELK 18 1 Q9UNE7;H3BS86 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 LGAGGGS(0.01)PEKS(0.015)PS(0.975)AQELK 91.845 0.0028682 427560000.0 10303.0 10506.0 14254.0 14693.0 9926.7 10712.0 10808.0 10935.0 6558.8 8609.4 True False 10543.039853851857 9275.952635893105 12318.385091617463 12127.14337176902 9028.831737701232 10604.247005717812 9992.743858429285 10644.968278114105 11129.804564201228 9714.500352657595 1.0852889465352276 0.9548563795517784 1.2680410360217367 1.2483548233596387 0.9294180256250869 1.0915895435442349 1.0286420809790358 1.0957813466136694 1.1456898615641564 1.0 13.245924080032124 -6.256289674206694 24.999168192107142 1.0544687785494027 1.1351800589825631 0.16813020433238834 0.09805297186441132 992.9213956712321 4820113.322510545 0.031065305266405042 0.03886424024407532 5.542559012248796e-07 6.256289674206694 0.08071128043316045 LGAGGGSPEKSPS(ph)AQELK ddPTM_A459_Selumetinib_30min_R2 2 LGAGGGSPEKSPSAQELK 18 1 Q9UNE7;H3BS86 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 LGAGGGSPEKS(0.047)PS(0.953)AQELK;LGAGGGSPEKS(0.133)PS(0.867)AQELK 81.44800000000002 0.0057313 23500200.0 139271.0 123674.0 124392.0 120495.0 114544.0 92735.0 102740.0 106595.0 84669.0 112457.0 True False 131530.87536598608 133159.39812541302 116388.75414776934 104083.37313453085 100153.95868364742 105508.40448548549 107517.61357544793 106905.17380224782 101605.16584952253 109210.07421162409 1.204384085584535 1.2192959219804267 1.0657327630987103 0.9530565186947967 0.9170761892311511 0.9661050525525181 0.9845027059234797 0.9788948004475311 0.930364406241818 1.0 16.73674641993246 -5.459492720363587 2.621984030189467 0.9598841694643562 1.2152434705023134 0.9421105380301993 0.024670101115391575 0.060251238333834986 0.8052799907342624 0.007266485039094444 0.017652320223426436 3.4714209462857227e-06 5.459492720363587 0.25535930103795723 LGAPENSGIST(ph)LER ddPTM_A459_Selumetinib_30min_R1 4 LGAPENSGISTLER 14 0 C9JME2;Q9Y4F1;Q9Y4F1-2;A0A1B0GV68;M0QYB0;Q9Y4F1-3 C9JME2 FARP1 FERM, RhoGEF and pleckstrin domain-containing protein 1 1 LGAPENSGIS(0.001)T(0.999)LER;LGAPENSGIS(0.001)T(0.999)LER;LGAPENSGIS(0.03)T(0.97)LER;LGAPENSGIS(0.033)T(0.967)LER 262.73 1.2196e-35 134731000.0 18808.399999999998 19606.8 21200.2 19360.4 20752.6 18113.8 17530.2 19337.9 8558.4 13756.6 True False 19246.599125224417 17311.226741045968 18321.329284362884 15979.469579718021 18875.53099416912 17931.591618014485 16207.88290035502 18824.996073648173 14522.979719195542 15522.39361063135 1.2399246925449914 1.115242093151757 1.1803159837291157 1.0294462297859537 1.2160193503430548 1.155207893048986 1.0441613134493752 1.212763736435266 0.9356147050187347 1.0 13.922063423151938 -8.268762721458275 24.99126089966431 0.9678073283273041 1.1439878919321995 0.5295273034249324 0.06822927383560387 468.18946265446493 1597697.9178819004 0.057781268429545535 0.016123727892799786 5.385639487349747e-09 8.268762721458275 0.17618056360489542 LGAPENSGIST(ph)LER ddPTM_A459_Selumetinib_30min_R2 3 LGAPENSGISTLER 14 0 C9JME2;Q9Y4F1;Q9Y4F1-2;A0A1B0GV68;M0QYB0;Q9Y4F1-3 C9JME2 FARP1 FERM, RhoGEF and pleckstrin domain-containing protein 1 1 LGAPENSGIS(0.046)T(0.954)LER;LGAPENSGIS(0.007)T(0.993)LER;LGAPENSGIS(0.016)T(0.984)LER 142.54 0.0012752 33437500.0 104688.0 44357.9 76113.0 79667.0 51619.3 59482.0 96263.0 71004.0 59381.0 55887.4 True False 98869.86005926838 47760.00829687114 71215.97244556856 68816.21716675948 45134.42205160295 67675.10557616492 100739.42024151587 71210.609884655 71258.85924376688 54273.785549096254 1.8216871931630854 0.8799829938832491 1.3121615108484805 1.2679457765942657 0.8316063011815197 1.2469206798730814 1.8561340290219233 1.3120627051200922 1.3129517044523433 1.0 15.727967918457143 -7.020455420849388 24.94418033378486 1.418468755064244 1.1939384070689016 0.034183769900924754 0.3213250650523116 1853.7445693729294 2260527.3368613753 0.11753999817628788 0.09218879637625695 9.539916624724667e-08 7.020455420849388 -0.22453034799534244 LGAQT(ph)PVGVSTLEPGQTLLPR ddPTM_A459_Selumetinib_30min_R2 2 LGAQTPVGVSTLEPGQTLLPR 21 0 O94887-3;O94887-2;O94887;C9JWM9;C9JVQ5 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 1 LGAQT(0.998)PVGVSTLEPGQT(0.002)LLPR;LGAQT(0.711)PVGVS(0.212)T(0.072)LEPGQT(0.005)LLPR 90.882 0.0016453 9632800.0 37918.0 35030.2 28485.0 34369.0 37890.0 28959.9 35741.1 32813.9 31557.8 32529.8 True False 35810.6693577806 37716.9037001539 26652.306112123013 29687.882910168028 33129.919459102224 32948.86335320228 37403.13196964608 32909.38301636641 37870.24179860465 31590.580151429334 1.1335869485815797 1.1939288078711456 0.843678906318443 0.9397701076668825 1.0487277948139626 1.0429964627196469 1.1839963619013736 1.0417467124255204 1.1987827262770667 1.0 14.947206811534665 -7.03225059054841 19.66795357849192 1.110165821275874 1.0274088403587516 0.10117990967124946 0.10536413593760233 117.12651564746196 71427.34016662664 0.042148765238944404 0.03273086653012584 9.28430522157536e-08 7.03225059054841 -0.08275698091712247 LGASEAAAFDS(ph)DESEAVGATR ddPTM_A459_Selumetinib_30min_R1 3 LGASEAAAFDSDESEAVGATR 21 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03 H3BLZ3 WWC1 Protein KIBRA 1 LGASEAAAFDS(0.655)DES(0.344)EAVGAT(0.001)R;LGASEAAAFDS(0.998)DES(0.002)EAVGATR;LGASEAAAFDS(0.985)DES(0.015)EAVGATR 222.13 1.0916e-20 12062500.0 3377.55 3270.8300000000004 3391.1400000000003 3633.79 3139.72 2748.22 3170.3 2769.59 1772.8799999999999 2216.27 True False 3456.240343431751 2887.879703032386 2930.6418141986546 2999.2167911863166 2855.7328803625887 2720.5754019841092 2931.161718576827 2696.1314763037994 3008.4478739679626 2500.749842797925 1.3820815997991989 1.1548055121744312 1.1719052278014948 1.1993269937910662 1.1419506387602114 1.087903858044528 1.1721131271960183 1.0781292195493153 1.2030183197380542 1.0 11.288145032462763 -1.9326566885956629 1.1237277554481844 1.131546599117695 199.99159591304334 0.6077632148830575 0.05969535740995867 808.8678587664616 1.6936239880577926 0.016949419000483138 413791.57080966834 0.01167732349069469 1.9326566885956629 198.86004931392566 LGASEAAAFDS(ph)DESEAVGATR ddPTM_A459_Selumetinib_30min_R2 3 LGASEAAAFDSDESEAVGATR 21 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03 H3BLZ3 WWC1 Protein KIBRA 1 LGASEAAAFDS(0.998)DES(0.002)EAVGATR;LGASEAAAFDS(0.998)DES(0.002)EAVGATR;LGASEAAAFDS(1)DESEAVGATR 200.89 9.6984e-17 11299500.0 29216.8 39363.2 36094.4 38925.8 46150.2 31204.1 36311.2 39181.6 34325.2 39242.6 True False 27593.047220117183 42382.230867362974 33772.1256006113 33624.03888924959 40352.39928797729 35502.18153238304 37999.742749277815 39295.61196913693 41191.19912622123 38109.56417348035 0.7240452054111552 1.1121153386701779 0.8861850386657694 0.8822992237903329 1.0588522897897028 0.9315819349382186 0.9971182713162866 1.0311220508914118 1.080862508390619 1.0 15.217865488923517 -4.744526525909817 24.960353201557893 0.9914865163768487 0.7240444017600103 0.5479204390429585 0.07439862354716259 815.2345199030012 1203075.4334439493 0.018615467128453696 0.5236942911621422 1.80083313950004e-05 4.744526525909817 -0.2674421146168384 LGASNS(ph)PGQPNSVK ddPTM_A459_Selumetinib_30min_R1 7 LGASNSPGQPNSVK 14 0 P49756 P49756 RBM25 RNA-binding protein 25 1 LGAS(0.015)NS(0.985)PGQPNSVK;LGAS(0.013)NS(0.98)PGQPNS(0.007)VK;LGAS(0.157)NS(0.799)PGQPNS(0.044)VK;LGAS(0.009)NS(0.974)PGQPNS(0.017)VK;LGAS(0.017)NS(0.983)PGQPNS(0.001)VK;LGAS(0.004)NS(0.967)PGQPNS(0.029)VK;LGAS(0.018)NS(0.979)PGQPNS(0.003)VK 222.75 4.5305e-09 1988277000.0 36753.08 43304.92 38729.2 39775.299999999996 36875.060000000005 30588.53 38613.4 34643.3 17763.809999999998 29795.65 True False 37609.35525495542 38234.7598344889 33469.98736426766 32829.29052985259 33539.71733382063 30280.837160363084 35700.7601501733 33724.44714670237 30143.888152650383 33620.21191170839 1.1186531290678092 1.1372551706366094 0.9955317191981049 0.976474824610479 0.9976057682771555 0.9006735959869915 1.0618838526041636 1.003100374122201 0.8966001830033866 1.0 15.037041197609767 -5.300101379329072 4.835763093239009 0.9788409505921666 1.1290852011172599 0.6240510687843017 0.046341341446819936 0.11565899163573878 6.715030978584825 0.012100096013531878 0.0276838002837528 5.0107025287422186e-06 5.300101379329072 0.15024425052509327 LGASNS(ph)PGQPNSVK ddPTM_A459_Selumetinib_30min_R2 7 LGASNSPGQPNSVK 14 0 P49756 P49756 RBM25 RNA-binding protein 25 1 LGAS(0.015)NS(0.979)PGQPNS(0.006)VK;LGASNS(0.973)PGQPNS(0.027)VK;LGAS(0.001)NS(0.993)PGQPNS(0.006)VK;LGAS(0.002)NS(0.708)PGQPNS(0.29)VK;LGAS(0.005)NS(0.995)PGQPNSVK;LGAS(0.022)NS(0.973)PGQPNS(0.004)VK;LGASNS(0.999)PGQPNS(0.001)VK 234.63 6.7757e-14 2949342600.0 1166760.0 973490.0 1165684.0 1189467.0 1156888.0 883578.0 987859.0 983501.0 818126.0 944452.0 True False 1101916.1501103456 1048153.552736292 1090685.1605407738 1027459.5426549768 1011549.386730056 1005282.8491775112 1033796.4009054729 986362.8250826434 981774.0603503815 917183.2167790084 1.2014133380897307 1.1427962631252992 1.1891682496885134 1.120233693616026 1.1028869349380874 1.0960545622584479 1.127142736579928 1.0754261602677184 1.0704230544015025 1.0 19.806850430215498 -1.5228787452860344 0.0735975408809173 0.8762239997714583 1.6969197582895348 0.8616039559505437 0.02075960582705481 79.85002115179961 0.43369406535998295 0.8020128389817937 6.736420725809361 0.029999999999606477 1.5228787452860344 0.8206957585180765 LGASNSPGQPNS(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 LGASNSPGQPNSVK 14 0 P49756 P49756 RBM25 RNA-binding protein 25 1 LGAS(0.001)NS(0.454)PGQPNS(0.546)VK 157.37 5.1645e-05 0.0 30030.0 26623.0 32118.0 31430.0 30948.0 25740.0 25893.0 26160.0 21166.0 23871.0 True False 28361.05281961473 28664.898493562607 30051.562847434347 27149.179780225833 27060.035561369634 29285.451355544297 27097.07580600613 26236.121268978863 25399.791427452667 23181.782205693547 1.2234198634067546 1.2365269520357405 1.2963439385628233 1.171142906068623 1.1672974632090007 1.2632959405662807 1.1688952801631864 1.1317560072035857 1.0956789776592055 1.0 14.500703863947233 -8.2657251196949 0.6395720166777963 0.9971361935915872 1.2350377465570035 0.7955251170875789 0.03716405274177511 0.32798115434974084 0.31156987891903765 0.03854770676777894 0.017297482307626774 5.423440504815376e-09 8.2657251196949 0.23790155296541626 LGAVGGS(ph)GFK ddPTM_A459_Selumetinib_30min_R2 2 LGAVGGSGFK 10 0 F5H2T0;O95163 F5H2T0 IKBKAP Elongator complex protein 1 1 LGAVGGS(1)GFK;LGAVGGS(1)GFK 94.616 0.023644 17178200.0 94129.0 84614.0 103988.0 93264.0 91202.0 73194.0 84179.0 81651.0 66274.0 83729.0 True False 88897.68700824218 91103.62172310808 97297.52529357381 80561.28231062632 79744.38940377519 83275.8091110221 88093.49029752414 81888.59089194935 79530.65185027858 81311.52621593208 1.0932974837068508 1.1204269057891247 1.1966018819421624 0.9907732158007537 0.9807267568930488 1.0241574963169875 1.0834071674362842 1.0070969603311197 0.9780981313654821 1.0 16.31117225381668 -5.773221837766005 24.99999935852661 1.0120069680604402 1.1351405765332907 0.712975918088055 0.03706464682556445 122.09719987218182 259065.60710388047 0.011109444870754893 0.016625221466847598 1.6856917535293402e-06 5.773221837766005 0.12313360847285049 LGDAS(ph)DTEAADGER ddPTM_A459_Selumetinib_30min_R1 1 LGDASDTEAADGER 14 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 LGDAS(0.995)DT(0.005)EAADGER 201.3 6.0184e-05 7556400.0 1333.4 1254.3 1164.2 1528.0 1031.9 1409.7 1273.2 1246.0 735.22 1173.8 True False 1364.4656256552526 1107.44597289175 1006.108034492848 1261.16348411237 938.5648271967418 1395.5196979051896 1177.1614989407988 1212.9520324215982 1247.6146416557945 1324.4686637802267 1.0301984961734532 0.8361435820844093 0.7596314371238266 0.9522033390452783 0.7086349816068437 1.0536449340539118 0.8887801811641267 0.915802740821105 0.9419736953948916 1.0 10.37119799538082 -6.779039853766192 24.999774511131506 0.9503241695763628 0.8560229240304885 0.2248794095802924 0.09444023214354162 412.13670194149637 585396.7030089883 0.032286131282981766 0.02853635323128471 1.6632600115042673e-07 6.779039853766192 -0.09430124554587427 LGDAS(ph)DTEAADGER ddPTM_A459_Selumetinib_30min_R2 1 LGDASDTEAADGER 14 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 LGDAS(1)DTEAADGER 186.29 8.2896e-05 16019000.0 31235.0 24888.0 26170.0 29265.0 33518.0 22681.0 27155.0 26089.0 23482.0 25741.0 True False 29499.08374361192 26796.829572466904 24486.2506917416 25279.056515059143 29307.16918527813 25805.101872381496 28417.76130661169 26164.91467073354 28179.05614189945 24997.79044685003 1.1800676466319087 1.0719679257029522 0.9795366011969714 1.0112516371719786 1.1723903857659197 1.0322953113495354 1.136810926030969 1.046689095436856 1.12726187547709 1.0 14.609512960346864 -4.76502676272045 6.246705849934343 1.0657936620709854 1.1835331723335558 0.24913191652334998 0.06035010249147229 0.18015898743629818 30.000730917896252 0.014928636747738007 0.09065208511003722 1.7178025269929474e-05 4.76502676272045 0.11773951026257046 LGDASDT(ph)EAADGER ddPTM_A459_Selumetinib_30min_R2 1 LGDASDTEAADGER 14 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 LGDAS(0.085)DT(0.915)EAADGER 191.19 0.00024636 20894000.0 36273.0 30805.0 40218.0 44299.0 40493.0 33234.0 32748.0 25882.0 33007.0 34403.0 True False 34257.09187232383 33167.644446313214 37630.417666047535 38265.39977996257 35405.907327986955 37811.68183178549 34270.84688893095 25957.312335004255 39609.322292635865 33409.69600027123 1.0253637708061072 0.992755050690792 1.1263322379749292 1.14533816110305 1.0597494609858025 1.1317577337871774 1.0257754781322383 0.7769394948937436 1.1855636846355713 1.0 15.027979234988077 -7.523595718008077 24.99999772976693 0.9690224714606855 1.0802332330317364 0.13715641964786862 0.10239472322657864 41.05102433839615 1431219.1942170365 0.04570844428602534 0.026700032128913993 2.995051413766525e-08 7.523595718008077 0.11121076157105081 LGDDEDREPSLRPDDDRVPR ddPTM_A459_Selumetinib_30min_R1 1 LGDDEDREPSLRPDDDRVPR 20 3 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 53.21 0.029348000000000006 7383500.0 891.89 943.69 772.41 906.17 859.92 980.42 967.01 886.28 379.47 648.59 False True 912.6693016841635 833.2023360904218 667.520964544426 747.9244204176098 782.1403878312072 970.5578649501356 894.0676571557827 862.772975356833 643.9328746077696 731.8428443016002 1.2470837267735078 1.13849898592033 0.9121097100859724 1.0219740839733922 1.0687272464590485 1.3261834456772503 1.2216661871019512 1.1789047089476974 0.879878623698612 1.0 9.515390067671053 -8.258635673986927 24.96318599275543 0.9399393032511092 1.1344868003813358 0.32356487953793056 0.11518009828631638 308.2688358174962 2744780.0173109095 0.09593285453051001 0.03262650798735016 5.512699582475416e-09 8.258635673986927 0.19454749713022657 LGDDEDREPSLRPDDDRVPR ddPTM_A459_Selumetinib_30min_R2 1 LGDDEDREPSLRPDDDRVPR 20 3 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 47.113 0.04367 9892900.0 50920.0 60830.0 129590.0 190710.0 227950.0 129110.0 66947.0 130560.0 144040.0 149550.0 False True 48090.0702489105 65495.46540072167 121252.32048692383 164734.96900689977 199312.88310114414 146893.73055611196 70060.1681529639 130939.90798462853 172852.0248138654 145232.1029224356 0.3311256208594188 0.45097099114305994 0.8348864889168568 1.1342875692909309 1.3723748337348773 1.0114411869017954 0.4824013888333014 0.9015906631508316 1.1901778004700576 1.0 17.148000864463206 -5.301530924986861 2.7955982547796103 1.001261011837807 0.3549120106108173 0.5600371455735511 0.21798906891576905 0.22519376483981163 3.434250605770224 0.06656543839314147 0.19162659088809217 4.9942361627797625e-06 5.301530924986861 -0.6463490012269897 LGDDNLCNTPHLPPCS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 1 LGDDNLCNTPHLPPCSPPK 19 0 J3KTI7;J3QR52;J3QLN7;Q99741 J3KTI7 CDC6 Cell division control protein 6 homolog 1 LGDDNLCNTPHLPPCS(1)PPK 154.39 4.8486000000000005e-06 9083900.0 4659.5 6993.5 5815.4 6559.5 4570.2 5261.8 5635.4 5280.1 3058.0 5277.7 True False 4768.057284191278 6174.697768810057 5025.70062170564 5414.006462064853 4156.826216934346 5208.871069332145 5210.317240913432 5140.054595818038 5189.202652516824 5955.144204151393 0.8006619354183591 1.036867883821455 0.8439259318359027 0.9091310430888798 0.6980227639217501 0.874684288199266 0.8749271322903089 0.8631284851565564 0.8713815274027079 1.0 12.539920728115908 -10.351877202531861 14.429250450000966 0.9999999989130098 0.8652611912270697 0.206556096850823 0.0801215337351431 0.0 0.0 0.07698339754182358 0.018671216440226686 4.447570054555793e-11 10.351877202531861 -0.13473880768594015 LGDDNLCNTPHLPPCS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 LGDDNLCNTPHLPPCSPPK 19 0 J3KTI7;J3QR52;J3QLN7;Q99741 J3KTI7 CDC6 Cell division control protein 6 homolog 1 LGDDNLCNTPHLPPCS(1)PPK;LGDDNLCNTPHLPPCS(1)PPK 130.38 0.00019106 20194100.0 121491.0 114456.0 108782.0 109437.0 112405.0 104658.0 124625.0 121480.0 89406.0 103176.0 True False 114739.01658700664 123234.40716595447 101783.08455288607 94531.49181064525 98283.67898655012 119073.68950926777 130420.30943975261 121833.48668790329 107289.6982123611 100197.04079655804 1.1451337851381749 1.2299206262605293 1.015829247487941 0.9434559250365865 0.9809040087931056 1.188395271583292 1.301638335852258 1.2159389710448265 1.070787094702768 1.0 16.61248037527359 -6.786966740853069 24.90118091800442 1.1779910774076259 1.0630520189156605 0.13715557761464892 0.10857003668785177 381.1212484142168 371769.3456984541 0.04118637319626863 0.036336170051961755 1.6331770150935083e-07 6.786966740853069 -0.1149390584919654 LGDLYEEEMR ddPTM_A459_Selumetinib_30min_R1 4 LGDLYEEEMR 10 0 P08670;B0YJC4 P08670 VIM Vimentin 0 ;;; 228.05 0.00011368 123685000.0 11702.9 11633.0 12376.099999999999 12733.9 13049.599999999999 10838.199999999999 11544.699999999999 11139.7 6243.0 9432.7 False True 11975.554800120632 10271.002951965023 10695.493597051134 10510.163409907407 11869.265984094007 10729.177548298243 10673.873984308708 10844.238969154794 10593.915029320642 10643.478927278717 1.1251541795632132 0.9650043018961539 1.0048869988964892 0.9874744415541024 1.1151678943689791 1.0080517490197576 1.0028557445584911 1.018862257655393 0.9953432615128269 1.0 13.37768216674034 -6.957928057462504 24.99989503498197 1.005781841506398 1.0336824039156738 0.10879775095893629 0.04796879894479086 422.1505152904736 250848.47581788767 0.016915259578167363 0.014917840292077223 1.1017217988443488e-07 6.957928057462504 0.027900562409275853 LGDLYEEEMR ddPTM_A459_Selumetinib_30min_R2 2 LGDLYEEEMR 10 0 P08670;B0YJC4 P08670 VIM Vimentin 0 ; 159.79 0.0062723 52436000.0 225200.0 195560.0 227010.0 224070.0 214600.0 159122.0 157849.0 181794.0 160662.0 198438.0 False True 212684.2855470276 210558.82317549086 212404.42374980007 193551.27945769005 187640.02945165825 181039.6111343016 165189.2912718595 182322.99044238337 192798.88927134994 192708.57933615762 1.1036575863912352 1.092628174110482 1.1022053324324774 1.0043729247781046 0.9736983693099731 0.9394475936564254 0.8571973901779747 0.946107283186091 1.0004686347411382 1.0 17.556061275910643 -5.986217478930454 1.7919062495797453 0.9418423374986202 1.1033582761540666 0.7381491445765811 0.038771009461201336 0.17733902321814676 1.1481981079266799 0.013370118806415863 0.02219777705668596 1.0322443657621553e-06 5.986217478930454 0.16151593865544633 LGDS(ph)SLSR ddPTM_A459_Selumetinib_30min_R1 1 LGDSSLSR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 LGDS(0.5)S(0.5)LSR 89.029 0.030241000000000007 8774300.0 4222.7 5897.2 4276.1 4434.0 5236.6 4454.7 5777.9 4655.9 2331.3 4222.6 True False 4321.080694056123 5206.7530824661 3695.4291069359765 3659.6851364883846 4762.950454596823 4409.88976254398 5342.068351186025 4532.410407505388 3956.045828584851 4764.611841607078 0.9069113786609417 1.0927969067696164 0.7755991946008195 0.7680972255767203 0.999651306955218 0.9255506868438937 1.1211969681425664 0.9512654038102358 0.8302976108228993 1.0 12.218142971620297 LGDSHDLQR ddPTM_A459_Selumetinib_30min_R1 2 LGDSHDLQR 9 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 ; 155.84 0.001167 30402000.0 11762.0 13381.5 13361.8 14795.7 13769.4 12089.3 12723.3 11187.7 7134.2 10368.099999999999 False True 12036.031715132052 11814.787759109418 11547.340951113662 12211.90874468679 12523.960201185015 11967.692618206145 11763.571237412407 10890.965853228825 12106.216338647982 11698.946628846285 1.0288132852452383 1.0099018427845035 0.9870410830528275 1.043846863492452 1.0705203296085206 1.0229718108720327 1.005523968149985 0.9309355960625371 1.0348125111364717 1.0 13.514091015191113 -10.434511341338176 5.2254596560344995 0.9999999713733362 1.0139365695658573 0.015065482223146631 0.035404356306505305 1.2614071554650696e-08 2.717435297648438e-09 0.03665129766400242 0.008889227107840715 3.676957910992598e-11 10.434511341338176 0.013936598192521132 LGDSHDLQR ddPTM_A459_Selumetinib_30min_R2 3 LGDSHDLQR 9 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 ;; 178.55 0.0012085000000000002 27432000.0 202622.0 195459.0 216771.0 231201.0 220346.0 158518.0 173486.0 181416.0 156929.0 180087.0 False True 191361.08040013237 210450.07680025726 202824.18986241953 199711.02495602943 192664.16556176645 180352.41561686737 181553.4427559873 181943.89052496452 188319.1849626157 174887.4203877818 1.0941957973639451 1.2033459944324274 1.1597414463126787 1.1419404809860292 1.101646791602094 1.0312486467978537 1.0381160769220836 1.0403486432674016 1.0768023483052773 1.0 17.416066994703478 -6.492827029900539 2.2372282643720265 1.039362432409429 1.1558686377061846 0.7488808534861765 0.030658193482173305 0.14870496463052477 1.4866983775970835 0.010648176544256151 0.011689888033732979 3.21494072504794e-07 6.492827029900539 0.1165062052967556 LGDSS(ph)GPALK ddPTM_A459_Selumetinib_30min_R2 2 LGDSSGPALK 10 0 Q9UHD8 Q9UHD8 SEPT9 Septin-9 1 LGDS(0.34)S(0.66)GPALK;LGDS(0.308)S(0.692)GPALK 96.229 0.021917 0.0 48595.0 55264.0 54456.0 67356.0 38550.0 38338.0 50975.0 50000.0 45763.0 42742.0 True False 45894.284441198084 59502.571098232525 50952.360247209836 58181.996604419124 33707.004358627346 43618.711502286584 53345.438505046266 50145.49172205442 54916.87872505509 41507.927402947236 1.105675164063706 1.4335230598386273 1.22753323124469 1.4017080650547722 0.81206185101485 1.050852553509802 1.2851867545007443 1.208094329433897 1.3230455520444935 1.0 15.341099275833518 LGDSS(ph)LSR ddPTM_A459_Selumetinib_30min_R1 2 LGDSSLSR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 LGDS(0.125)S(0.874)LSR;LGDS(0.043)S(0.957)LSR 117.53 0.0088168 87969000.0 13191.9 16851.4 11488.0 13185.2 12707.0 13113.3 15322.2 13272.8 7098.0 11918.5 True False 13499.245603030995 14878.430253996681 9927.992699067026 10882.652336857616 11557.654093603056 12981.392107923766 14166.434118026014 12920.762227869483 12044.787582591372 13448.355571021159 1.0037841081566505 1.106338256407875 0.7382309789949416 0.8092180697770825 0.8594102106065494 0.9652772816251515 1.0533952677866572 0.9607689326501341 0.8956327425299322 1.0 13.715142154221839 -6.890797908926218 7.0255025386706444 0.9789789622718896 0.9005398732613925 0.1113851287025227 0.101325217006669 0.5577678465413252 32.627895564651396 0.03956253254177319 0.034896060123693555 1.2858848839948851e-07 6.890797908926218 -0.07843908901049712 LGDSS(ph)LSR ddPTM_A459_Selumetinib_30min_R2 4 LGDSSLSR 8 0 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 LGDS(0.347)S(0.653)LSR;LGDS(0.045)S(0.955)LSR;LGDS(0.128)S(0.871)LSR;LGDS(0.128)S(0.871)LSR 123.21 0.0060247 130836000.0 853428.0 562090.0 752131.0 792743.0 813362.0 906842.0 903980.0 813916.0 745631.0 687560.0 True False 805997.8883029687 605200.4955957864 703739.7103183148 684770.0358420495 711180.1940114615 1031751.2540079457 946016.8612023889 816284.3608089532 894778.0346708405 667708.356304582 1.2071106804230327 0.9063844864025006 1.053962712423052 1.0255525924999578 1.065106026151108 1.5452124333416337 1.416811475054917 1.2225163173434912 1.3400731415478622 1.0 19.348858569967604 -6.633360365427677 9.291503571423224 1.3254874115878101 1.0394717246158922 0.4186202078237664 0.14820463780683255 0.24602190769121535 19.298699896768277 0.047291834678821254 0.04726563543641273 2.3261602738310894e-07 6.633360365427677 -0.2860156869719179 LGDVISIQPCPDVK ddPTM_A459_Selumetinib_30min_R2 1 LGDVISIQPCPDVK 14 0 P55072;C9JUP7;C9IZA5 P55072 VCP Transitional endoplasmic reticulum ATPase 0 154.28 0.0048087 2810000.0 21559.0 24301.0 24262.0 24499.0 26303.0 18362.0 18839.0 20147.0 19327.0 21955.0 False True 20360.837087514934 26164.80855996939 22701.009334468272 21162.193936867738 22998.58198819652 20891.198826359916 19715.05082877031 20205.6244344846 23192.94004149948 21321.102104059377 0.9549617551729835 1.2271789906670822 1.0647202580651856 0.9925469065146785 1.0786769781388441 0.9798367234676105 0.924673158664566 0.9476819882888513 1.0877927383070747 1.0 14.379994393583036 -5.629759763095666 4.5923594208602605 0.9987808077889583 1.1030722961084274 0.18343830152019114 0.0777015789376763 0.2906095115726272 10.372319008754163 0.02098128864748909 0.037511673570084794 2.3455259215212253e-06 5.629759763095666 0.1042914883194691 LGDVS(ph)PTQIDVSQFGSFK ddPTM_A459_Selumetinib_30min_R1 2 LGDVSPTQIDVSQFGSFK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 LGDVS(0.953)PT(0.047)QIDVSQFGSFK;LGDVS(1)PTQIDVSQFGSFK 219.72 2.3947e-14 1612660000.0 14734.2 25504.0 10776.400000000001 12522.0 12994.900000000001 13936.0 16505.4 14589.699999999999 7889.8 15326.0 True False 15077.478192237606 22517.979823512076 9313.024070528021 10335.267767051779 11819.51358943594 13795.816492875596 15260.38438942622 14202.733761975434 13388.41435180747 17293.2413878819 0.8718711463082351 1.302126034006058 0.5385354810957562 0.5976478055926597 0.6834758923632657 0.7977577010254945 0.882447890892208 0.821288123111951 0.7741992407039027 1.0 14.0779206878551 -5.261565065364704 24.99999998716274 0.7524526385361703 1.0869985815674619 0.40006066888440706 0.15889771708577755 10.217996638796963 2032957.962272142 0.04122830025191674 0.09567995213296464 5.475640595690622e-06 5.261565065364704 0.3345459430312916 LGDVS(ph)PTQIDVSQFGSFK ddPTM_A459_Selumetinib_30min_R2 5 LGDVSPTQIDVSQFGSFK 18 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 LGDVS(0.999)PT(0.001)QIDVSQFGSFK;LGDVS(0.696)PT(0.304)QIDVSQFGSFK;LGDVS(0.969)PT(0.031)QIDVSQFGSFK;LGDVS(0.93)PT(0.07)QIDVSQFGSFK;LGDVS(0.92)PT(0.08)QIDVSQFGSFK 185.2 2.5226e-10 850798300.0 699423.2000000001 599712.0 643616.2000000001 728046.7 934447.6 748545.6000000001 850695.4 874166.7 989010.5 614745.1 True False 660552.0585569082 645707.982021988 602206.6344083338 628885.4835093905 817053.9384204644 851650.9617795923 890254.421720955 876710.3803709124 1186840.2352622459 596995.8116634127 1.1064601219167824 1.0815954976683142 1.0087284075417584 1.0534169105091766 1.3686091635113864 1.4265610329939042 1.491223898607319 1.4685369030113116 1.9880210414799167 1.0 19.18736128446354 -6.452642561458182 1.9646998688858452 1.5132427141977078 1.0532845967258855 0.42587522638574704 0.22475593503646193 0.3003957693170813 2.308940936726216 0.07877094122271619 0.0896506717785084 3.5266100315482536e-07 6.452642561458182 -0.45995811747182236 LGDVSPT(ph)QIDVSQFGSFKEDTK ddPTM_A459_Selumetinib_30min_R1 2 LGDVSPTQIDVSQFGSFKEDTK 22 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 LGDVS(0.443)PT(0.556)QIDVS(0.001)QFGSFKEDTK;LGDVS(0.106)PT(0.894)QIDVSQFGSFKEDTK 113.65 5.1369e-05 279840000.0 7660.4 5338.6 13412.9 12958.8 9203.900000000001 7698.3 7331.9 6969.700000000001 4714.7 4947.4 True False 7838.872415456345 4713.554230152192 11591.50185178588 10695.788846803267 8371.40887008053 7620.862091497144 6778.848880053441 6784.840915223765 8000.501551936256 5582.446981756942 1.404200065145849 0.8443527086877435 2.0764195145365685 1.91596783305894 1.4995948725420458 1.3651472403413065 1.2143149594087073 1.2153883301348252 1.4331531634928827 1.0 12.446681929049369 -6.894815200235352 2.8513993097611765 1.2373196237305726 1.5605731135594632 0.19252813101730437 0.32063858915127047 0.5280389652296954 8.666366649773217 0.13428452635893084 0.1155743822616868 1.2740450937702693e-07 6.894815200235352 0.3232534898288906 LGDVYVNDAFGT(ph)AHR ddPTM_A459_Selumetinib_30min_R1 2 LGDVYVNDAFGTAHR 15 0 P00558-2;P00558;P07205 P00558-2 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 1 LGDVYVNDAFGT(1)AHR;LGDVYVNDAFGT(1)AHR 144.74 0.00050445 5152500.0 3418.8 5706.0 5495.9 6407.1 5748.3 4631.6 5767.299999999999 4823.5 2194.6 4286.7 True False 3498.4513881732255 5037.938867352567 4749.586966817762 5288.220261162547 5228.36727994479 4585.010309156328 5332.267917720133 4695.565111063866 3724.075912757822 4836.939700993949 0.7232778584058684 1.041555028341022 0.9819404955248383 1.0932987773397016 1.0809246348203196 0.9479155401118909 1.102405290813197 0.970771893248735 0.7699239897475995 1.0 12.23987883740984 -10.72200001728067 14.54785557353393 1.0000025597051723 0.9810250639722033 0.0 0.12376665085598929 0.0 0.0 0.11853468210609773 0.02874888321308545 1.896705845740812e-11 10.72200001728067 -0.01897749573296892 LGDVYVNDAFGTAHR ddPTM_A459_Selumetinib_30min_R1 1 LGDVYVNDAFGTAHR 15 0 P00558-2;P00558;P07205 P00558-2 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 242.41 3.8064e-20 55283000.0 5074.1 5762.4 5857.0 6315.1 6503.8 5139.6 5463.0 5424.3 3201.5 4425.0 False True 5192.31665752011 5087.735529132921 5061.651570198085 5212.28633410866 5915.532438339154 5087.900290383426 5050.9215117134645 5280.429943390426 5432.7116716915 4992.991853150031 1.039920915201239 1.018975331578624 1.0137512175199601 1.0439204563933504 1.1847670920206093 1.0190083300803943 1.0116021936881163 1.057568307478622 1.0880674015648661 1.0 12.28568883734859 -6.00030238046387 24.999874380820888 1.0636321034925733 1.024549104613472 0.09378859177313581 0.04943574617080381 25.90071762521934 2141991.6693600114 0.014447954893733399 0.021161973425896298 9.993039855819661e-07 6.00030238046387 -0.03908299887910127 LGDVYVNDAFGTAHR ddPTM_A459_Selumetinib_30min_R2 4 LGDVYVNDAFGTAHR 15 0 P00558-2;P00558;P07205 P00558-2 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 ;;; 172.82 5.1259e-05 24796900.0 178410.0 162253.0 182548.0 184340.0 209982.0 154682.0 151612.0 167413.0 131041.0 174004.0 False True 168494.68643181704 174697.2833743758 170803.0604232346 159232.57399576297 183602.18389710205 175988.04143660836 158662.25841347864 167900.1441132857 157252.86159145914 168980.05240331322 0.9971276729732707 1.03383376256398 1.010788303080711 0.942315804327688 1.0865317017353588 1.0414722858327017 0.9389407575445143 0.9936092557987256 0.9306001469104518 1.0 17.36649342510198 -7.259181006919587 24.997387610941235 0.9652549779095512 1.0186217348237185 0.3006321735537807 0.03951689274263764 263.64822148270196 2918274.8557620714 0.015757721385177222 0.011612404625172957 5.505781764948921e-08 7.259181006919587 0.05336675691416737 LGEAS(ph)DSELADADK ddPTM_A459_Selumetinib_30min_R1 2 LGEASDSELADADK 14 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 LGEAS(0.948)DS(0.052)ELADADK;LGEAS(0.892)DS(0.108)ELADADK 272.72 1.5191e-44 64844000.0 11824.9 13596.5 9577.0 9701.2 9296.5 10501.3 10967.3 10846.0 6779.9 11194.5 True False 12100.397162749956 12004.61545915863 8276.496002695412 8007.067534077841 8455.633216430382 10395.666456417519 10140.027731176117 10558.328847226841 11504.99511569614 12631.423118663955 0.9579599265320021 0.9503771147861267 0.6552306834268117 0.6339006665247994 0.6694125544679519 0.8230004140275434 0.8027620986105201 0.8358780121636533 0.9108233496427314 1.0 13.624729568997722 -8.33111564355678 1.1796038411510186 0.9982618721601646 0.7736900309320509 0.30639877271602767 0.10585163573507103 0.6243671582192188 1.8030837002009914 0.11275642974741319 0.036324449788651805 4.665351352031933e-09 8.33111564355678 -0.2245718412281137 LGEAS(ph)DSELADADK ddPTM_A459_Selumetinib_30min_R2 4 LGEASDSELADADK 14 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 LGEAS(0.864)DS(0.136)ELADADK;LGEAS(0.856)DS(0.144)ELADADK;LGEAS(0.992)DS(0.008)ELADADK;LGEAS(0.999)DS(0.001)ELADADK 235.93 1.0315e-14 118618000.0 375903.0 286917.0 311648.0 320317.0 299585.0 253271.0 327351.0 303712.0 217118.0 289766.0 True False 355011.8161189353 308922.6113164364 291596.9069766866 276689.2720223537 261948.45397611862 288156.78128477314 342573.4701337008 304595.7516377716 260547.66678378885 281399.70267751656 1.2615927193277032 1.0978071702885237 1.0362374380716957 0.9832607120393407 0.9308767972520248 1.0240123871594853 1.2173910166717172 1.0824309647080106 0.9258988702002144 1.0 18.102261278683258 -4.765834288796845 2.1848900726954894 1.0300520404766895 1.328874823325311 0.45465788687170494 0.07856487673927869 0.7153990966227802 3.8182994890641435 0.022830798215800235 0.4298229238656866 1.7146114169493817e-05 4.765834288796845 0.2988227828486214 LGEASDS(ph)ELADADK ddPTM_A459_Selumetinib_30min_R1 2 LGEASDSELADADK 14 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 LGEAS(0.135)DS(0.865)ELADADK;LGEAS(0.365)DS(0.635)ELADADK 249.36 2.052e-27 70870000.0 8891.5 10357.0 7315.9 6898.099999999999 6255.599999999999 7798.7 8097.299999999999 7666.3 5220.1 8731.9 True False 9098.65465015275 9144.39762516133 6322.44096336216 5693.476328374047 5689.782084515884 7720.252158653046 7486.514141826371 7462.964820348068 8858.128438980726 9852.72442090865 0.9234658619746154 0.9281085347069926 0.6416946920737162 0.5778580710419359 0.5774831246108428 0.783565217988819 0.7598420317063878 0.7574518987368379 0.8990537094676806 1.0 13.266306990455757 -8.414384170339273 1.7284461896035186 1.001069540672764 0.7325689823092968 0.35092307783864596 0.115853700987712 0.43452358024496013 2.744247047662548 0.12430475731688215 0.03606397557882635 3.851375201048032e-09 8.414384170339273 -0.2685005583634673 LGEASDS(ph)ELADADKASVASEVSTTSSTSKPPTGR ddPTM_A459_Selumetinib_30min_R2 1 LGEASDSELADADKASVASEVSTTSSTSKPPTGR 34 2 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 LGEAS(0.217)DS(0.782)ELADADKAS(0.001)VASEVSTTSSTSKPPTGR 60.912 0.00017917 5380700.0 10708.0 11819.0 10957.0 12071.0 9188.1 8733.9 6067.9 4109.4 3326.5 12438.0 True False 10112.89222752029 12725.479295925194 10252.038549079589 10426.908976363546 8033.80873534381 9936.915446549656 6350.069373315743 4121.357673652209 3991.892950175814 12078.882622194971 0.8372373955300989 1.0535311662472902 0.848757196318925 0.863234564197526 0.665111913628639 0.8226684336091282 0.5257166223014269 0.34120355355380355 0.3304852837000587 1.0 13.560199381399704 -6.772537820051601 1.091177745016359 0.5007913572971243 0.9180217359796232 0.34816361332685 0.19547823644937573 0.4721015391359183 1.1956244435568313 0.10395531080994382 0.0929576985429341 1.6883488251063274e-07 6.772537820051601 0.4172303786824989 LGELLGNPEGQS(ph)LGSSPSQDR ddPTM_A459_Selumetinib_30min_R2 1 LGELLGNPEGQSLGSSPSQDR 21 0 O75123-2;O75123 O75123-2 ZNF623 Zinc finger protein 623 1 LGELLGNPEGQS(0.79)LGS(0.076)S(0.105)PS(0.028)QDR 64.842 0.010542 1400100.0 5363.2 5740.6 6395.4 6362.0 6637.9 5415.4 4726.4 4665.4 4919.7 7157.6 True False 5065.134814590669 6180.885561061694 5983.926926785033 5495.484624937855 5803.987658421077 6161.322193893337 4946.186965183929 4678.9755416014505 5903.777467903193 6950.941490321818 0.7286976622725335 0.8892155932642628 0.8608800599338647 0.7906101112474511 0.8349930245424008 0.8864011015589885 0.7115851819599949 0.6731427027714516 0.8493493257170055 1.0 12.762992685724976 -7.249535333918855 24.85743730923398 0.7812811892491469 0.8340041515595794 0.0 0.0940809200192773 2084.8786487636394 4353545.752829711 0.034768141574205984 0.0267028875094993 5.6294331482613324e-08 7.249535333918855 0.0527229623104325 LGELLGNPEGQSLGS(ph)SPSQDR ddPTM_A459_Selumetinib_30min_R1 1 LGELLGNPEGQSLGSSPSQDR 21 0 O75123-2;O75123 O75123-2 ZNF623 Zinc finger protein 623 1 LGELLGNPEGQSLGS(0.778)S(0.22)PS(0.001)QDR 178.84 3.497300000000001e-14 2461900.0 681.28 738.27 862.77 724.92 599.85 614.99 558.06 665.66 362.58 517.24 True False 697.1524984598849 651.8330051875885 745.6105728563767 598.32633043373 545.5936734121191 608.8037589662432 515.9650849033164 648.0045344315895 615.2717782045613 583.6327923442536 1.1945053595423611 1.1168546622772821 1.277533720923243 1.0251759981313893 0.934823540707258 1.0431280883325393 0.8840577357397292 1.1102949370421367 1.054210432099308 1.0 9.188917135441997 -5.8579314762324355 7.18367058400832 1.003873598204922 1.18763150504437 0.6103471664483802 0.06916356295014137 0.1489898957376082 9.541050056049807 0.0193911590992609 0.02896426304951191 1.3869746509732656e-06 5.8579314762324355 0.18375790683944793 LGELLGNPEGQSLGSS(ph)PSQDR ddPTM_A459_Selumetinib_30min_R2 1 LGELLGNPEGQSLGSSPSQDR 21 0 O75123-2;O75123 O75123-2 ZNF623 Zinc finger protein 623 1 LGELLGNPEGQSLGS(0.284)S(0.712)PS(0.004)QDR 108.37 0.00059968 0.0 3114.2 3563.4 3848.4 4863.3 5980.8 2359.4 3674.1 4988.4 3929.3 2866.3 True False 2941.1252311303415 3836.70132186309 3600.7981338211057 4200.910150339557 5229.438434969608 2684.385933499271 3844.952930091033 5002.915418125924 4715.269793815069 2783.5424714582286 1.0566123065438837 1.3783519961357507 1.2936027277265638 1.5091956359260452 1.878698991874924 0.9643775731911098 1.381316423053088 1.7973195916443196 1.6939816231166955 1.0 11.442706380761363 -4.112116001681887 1.0109982484367122 1.477490229090974 1.840797284458034e-14 0.13229361382218097 0.28936289342776006 12.556622553280873 3.951355097832482 0.09355542448843894 27.867351136147974 7.724742267796789e-05 4.112116001681887 -1.4774902290909555 LGELTMQLHPVADS(ph)SPAGAK ddPTM_A459_Selumetinib_30min_R1 1 LGELTMQLHPVADSSPAGAK 20 0 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038 H0YIS7 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 LGELTMQLHPVADS(0.5)S(0.5)PAGAK 114.75 0.0001811 19799000.0 1963.6 2749.5 2891.7 3061.0 2271.3 2022.3 2280.9 2328.5 1619.6 2026.0 True False 2009.348059499516 2427.587261792129 2499.02302297111 2526.4538120863667 2065.861316030585 2001.957498101486 2108.8498766368753 2266.740615966045 2748.342909096222 2286.056834911177 0.8789580507422459 1.0619102835588299 1.0931587460152572 1.10515791799399 0.9036788956783975 0.8757251646279698 0.9224835727755707 0.9915504205100473 1.2022198517225433 1.0 11.158645556292006 -12.591759059441813 15.184589843246124 1.0062395142010696 1.001610940954486 0.0 0.10479957925083658 0.0 0.0 0.0 0.025212294460129524 2.560005748710912e-13 12.591759059441813 -0.004628573246583612 LGELTMQLHPVADS(ph)SPAGAQIK ddPTM_A459_Selumetinib_30min_R1 2 LGELTMQLHPVADSSPAGAQIK 22 0 Q8IXM2-2 Q8IXM2-2 BAP18 Chromatin complexes subunit BAP18 1 LGELTMQLHPVADS(0.635)S(0.365)PAGAQIK;LGELTMQLHPVADS(0.955)S(0.045)PAGAQIK 170.68 4.0231e-12 82559000.0 5405.8 7268.700000000001 7555.0 8178.799999999999 6826.6 6105.200000000001 5912.4 5736.5 3085.4 4924.799999999999 True False 5531.744622144266 6417.67722487305 6529.072496644448 6750.52611509048 6209.13523533412 6043.787231078076 5466.42290789945 5584.3493852219035 5235.6984513000025 5556.946051614299 0.9954648777879151 1.154892843166744 1.174938974753542 1.2147906516258953 1.1173646779475859 1.0876094845877349 0.9837099113660548 1.004931365781326 0.9421899011920453 1.0 12.440076518931717 -7.109531035549463 2.1459065837027986 0.9793379368570886 1.1403735862777176 0.6147512775600183 0.0555675261872833 0.21900875580647292 1.9852210718480052 0.026279409812245903 0.019036990407661755 7.770857847100825e-08 7.109531035549463 0.16103564942062898 LGELTMQLHPVADS(ph)SPAGAQIK ddPTM_A459_Selumetinib_30min_R2 1 LGELTMQLHPVADSSPAGAQIK 22 0 Q8IXM2-2 Q8IXM2-2 BAP18 Chromatin complexes subunit BAP18 1 LGELTMQLHPVADS(0.573)S(0.427)PAGAQIK 80.664 0.0030229 0.0 13826.0 12553.0 14542.0 18478.0 16151.0 11061.0 12664.0 14694.0 7373.5 15957.0 True False 13057.606269863241 13515.774735743216 13606.383552132454 15961.264523672058 14121.966988228036 12584.552348239135 13252.90109323993 14736.757107277355 8848.406032803661 15496.279948734946 0.8426284445725448 0.8721947964580099 0.8780419298789982 1.0300062064234372 0.9113133626229369 0.8121015101606038 0.8552311352843006 0.9509867630185918 0.5710019476981641 1.0 13.919634301910135 -6.750055115528966 23.998928556745145 0.8358863775080916 0.9101554258361478 0.08178786182747266 0.1151880264343377 350.68292637172027 739264.4376439733 0.03708211941116427 0.0367382805533066 1.7780537461277005e-07 6.750055115528966 0.07426904832805625 LGELWEEMALS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LGELWEEMALSPR 13 0 Q9NWQ4-4;Q9NWQ4;G3V5D0;G3V290;G3V553;Q9NWQ4-1 Q9NWQ4-4 GPATCH2L G patch domain-containing protein 2-like 1 LGELWEEMALS(1)PR 131.08 0.0015598 6415700.0 967.77 1186.0 1255.8 1151.7 1391.2 1022.3 1181.9 995.35 377.18 811.27 True False 990.3171580473847 1047.1425686435584 1085.2692576156312 950.57721508653 1265.3662056363094 1012.0165901741334 1092.7483314468511 968.9500846475427 640.046911862752 915.4044069389887 1.0818356898224861 1.1439125273004613 1.1855626315418906 1.038423245377587 1.3823029428791525 1.1055404392886912 1.1937328716833262 1.058494013468435 0.6991957947886642 1.0 9.838265427151054 -8.052097109341625 5.374551901358594 0.8520434309641518 1.1616079241218664 0.557244178135569 0.10994539492954784 0.14364279494892512 9.20215792091814 0.07109728426466681 0.02677518776860266 8.869576638922911e-09 8.052097109341625 0.3095644931577146 LGEYEDVSR ddPTM_A459_Selumetinib_30min_R1 1 LGEYEDVSR 9 0 K7EK42;A0A494C0X0;Q99426;K7EP07;Q99426-2;K7EL99 K7EK42 TBCB Tubulin-folding cofactor B 0 167.23 0.011827 13736000.0 2923.9 3090.5 3424.4 3506.1 3447.6 2932.6 3305.9 2739.7 1688.4 2328.9 False True 2992.021181080992 2728.6628232655275 2959.38528888276 2893.825452648156 3135.7651887232155 2903.100706587755 3056.5333014046405 2667.0342562002015 2865.091484143035 2627.8370004070293 1.1385870511061202 1.038368370200618 1.1261677525753602 1.1012195399486069 1.1932875548359783 1.1047491553464275 1.1631365647607557 1.0149161670937357 1.0902850837777445 1.0 11.359660075543976 -7.768761704622865 24.998813717226014 1.0394504574398629 1.1215515526626674 0.4560839426742277 0.0442091378158422 168.88217996459431 576561.8778010942 0.023349796264044764 0.011566042331752114 1.7030927311882725e-08 7.768761704622865 0.08210109522280451 LGEYEDVSR ddPTM_A459_Selumetinib_30min_R2 1 LGEYEDVSR 9 0 K7EK42;A0A494C0X0;Q99426;K7EP07;Q99426-2;K7EL99 K7EK42 TBCB Tubulin-folding cofactor B 0 141.52 0.030464 12357000.0 45815.0 49526.0 43426.0 54721.0 63676.0 36359.0 44875.0 37979.0 35519.0 46844.0 False True 43268.78571197629 53324.4849488105 40632.01843865384 47267.90540100982 55676.451609337404 41367.12221585995 46961.77641812556 38089.512602238065 42623.7924837802 45491.49200467128 0.9511401760033118 1.172185887931196 0.8931784087117115 1.0390493544629429 1.223887130446728 0.9093375572648217 1.0323199866318586 0.8372887088057445 0.9369618494685421 1.0 15.47330913166509 LGFSLT(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 LGFSLTPSK 9 0 P38432 P38432 COIL Coilin 1 LGFS(0.01)LT(0.988)PS(0.002)K;LGFS(0.002)LT(0.998)PSK 166.86 0.0020558000000000004 514490000.0 20638.2 22045.5 20857.5 21664.8 18843.7 17768.8 19228.8 17195.8 10785.0 16563.8 True False 21119.029905053427 19464.4026113251 18025.16606204654 17881.449378663405 17139.29066212544 17590.062004779553 17778.356134804308 16739.711524169594 18301.357294765843 18689.92507507491 1.129968676718667 1.0414382365439785 0.9644322269694436 0.9567426999753094 0.9170336742003631 0.9411520877757746 0.951226720459876 0.8956542873729257 0.9792097732469103 1.0 14.189973165110073 -4.887437655898422 1.4038568267776346 0.9420813558905481 1.1858275833706173 0.8098179002248816 0.02785971531993435 0.37385267703606323 0.7764891149285496 0.007657363892616633 0.12267161605748532 1.295872710060819e-05 4.887437655898422 0.24374622748006924 LGFSLT(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 LGFSLTPSK 9 0 P38432 P38432 COIL Coilin 1 LGFS(0.001)LT(0.989)PS(0.009)K 112.94 0.021993 131260000.0 124780.0 106890.0 117320.0 138710.0 127690.0 95286.0 105600.0 92264.0 85327.0 114810.0 True False 117845.2271339169 115088.11929447853 109771.75892835764 119817.4587119033 111648.44063691638 108410.78157981322 110510.60924243028 92532.4729648726 102394.78423557853 111495.13698779557 1.056953965147524 1.0322254620582803 0.9845430203863818 1.0746429122287073 1.0013749805889525 0.9723364131269692 0.9911697696243643 0.8299238465889445 0.9183789266682261 1.0 16.766621260846144 -7.163979931136809 1.4861268931690623 0.9116991626687114 1.0310138843177803 0.466381105816416 0.04878949462502636 0.32684248612030886 1.4255444494435001 0.026483281375806727 0.01708711809686285 6.855199037773124e-08 7.163979931136809 0.11931472164906887 LGFSS(ph)SPTK ddPTM_A459_Selumetinib_30min_R2 1 LGFSSSPTK 9 0 Q8IVF2;Q8IVF2-3;Q8IVF2-2 Q8IVF2 AHNAK2 Protein AHNAK2 1 LGFS(0.202)S(0.398)S(0.398)PT(0.002)K 115.23 0.0082322 45389000.0 658840.0 624860.0 530870.0 611010.0 598990.0 450830.0 598760.0 562380.0 476250.0 519550.0 True False 622224.3103454874 672784.7527584241 496714.40216755273 527789.3839489601 523739.5211614578 512927.7402727281 626603.5264204314 564016.4326929789 571513.3075368197 504549.2415469848 1.2332281155308098 1.3334372492476987 0.9844716060707773 1.0460611977747094 1.038034502946896 1.0166059088703694 1.241907577740518 1.117862016725391 1.1327205760621464 1.0 18.944635550644406 -5.253905886172509 24.99773697959851 1.078337905085353 1.283332697056952 0.5516434923924589 0.07597388942527925 450.7456973662984 1495661.2074818055 0.02044509765167456 0.051934785263615654 5.573065070072399e-06 5.253905886172509 0.2049947919715991 LGFSS(ph)SPTKK ddPTM_A459_Selumetinib_30min_R1 1 LGFSSSPTKK 10 1 Q8IVF2;Q8IVF2-3;Q8IVF2-2 Q8IVF2 AHNAK2 Protein AHNAK2 1 LGFS(0.014)S(0.493)S(0.493)PTKK 163.12 0.00071372 141770000.0 5525.1 5220.5 6856.5 7308.7 5531.3 4532.5 4834.7 5820.5 3564.0 4613.7 True False 5653.824080026879 4609.281433055396 5925.424960058591 6032.372746290628 5030.994891630333 4486.907165180728 4470.0146865606985 5666.1214323514505 6047.847695739033 5205.913336243682 1.0860388398448417 0.8853934238523483 1.1382104497986267 1.1587539700849643 0.9664000467707436 0.8618866422425403 0.8586417786558909 1.0884010290574353 1.1617265415530038 1.0 12.345935579805543 -4.423351526184986 21.800685875296196 1.0118225666211267 12.063310794966608 0.03522239101349878 0.11403097836774805 2189.760980134553 474892.8376429213 0.02978837877767566 11971.536914407809 3.772667004893783e-05 4.423351526184986 11.05148822834548 LGFSSS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 LGFSSSPTK 9 0 Q8IVF2;Q8IVF2-3;Q8IVF2-2 Q8IVF2 AHNAK2 Protein AHNAK2 1 LGFS(0.01)S(0.207)S(0.717)PT(0.067)K 128.51 0.004305600000000001 51473000.0 752200.0 667420.0 693770.0 825910.0 686050.0 470190.0 759880.0 728740.0 543100.0 555490.0 True False 710395.7352951779 718608.9679064559 649133.5935196638 713419.6332257815 599862.2656351821 534954.4045401468 795215.925673654 730860.5127505994 651735.1754818847 539451.5603636513 1.3168851246185866 1.3321102777458504 1.2033213752909984 1.3224906287134588 1.111985412055917 0.991663466835701 1.4741192427686902 1.3548213898165702 1.2081440176807379 1.0 19.0411338942787 -8.551698265736748 20.92177062756225 0.9999999939044435 1.2600264587143974 0.27460632933574547 0.12818068158092158 1406.1299252450744 1020792.3627837611 0.13059078963820492 0.03371839690959231 2.807383443013875e-09 8.551698265736748 0.26002646480995395 LGFSSS(ph)PTKK ddPTM_A459_Selumetinib_30min_R1 1 LGFSSSPTKK 10 1 Q8IVF2;Q8IVF2-3;Q8IVF2-2 Q8IVF2 AHNAK2 Protein AHNAK2 1 LGFS(0.004)S(0.14)S(0.831)PT(0.024)KK 139.76 0.0026797 161170000.0 4258.6 4695.9 5523.4 6206.6 4290.3 4189.5 4120.4 4476.8 2486.8 3593.4 True False 4357.817094206886 4146.101844935316 4773.352617864451 5122.7338223114175 3902.243122513988 4147.357433761648 3809.594910646927 4358.060721304179 4219.917971314204 4054.6478926800733 1.074770783937646 1.0225553376460497 1.1772545346001233 1.2634226097806367 0.9624123292083576 1.0228650041965284 0.9395624506691334 1.074830869820253 1.0407606487686627 1.0 11.98536092030305 -6.293463970608613 24.979043777976536 1.0079276072714287 1.1295586176586345 0.45271251912196875 0.06872507749084616 680.8829245179157 531084.1265028008 0.022943540875771343 0.026017300292376082 5.087870272419168e-07 6.293463970608613 0.1216310103872058 LGGAVPFAPPEVS(ph)PEQAK ddPTM_A459_Selumetinib_30min_R1 2 LGGAVPFAPPEVSPEQAK 18 0 A0A096LP25;A0A096LNZ0;Q6ZSR9 A0A096LP25 AAK1 Uncharacterized protein FLJ45252 1 LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK 216.34 3.6791000000000003e-14 257270000.0 9520.0 10039.0 11133.8 11581.5 9762.9 8584.2 9402.2 9270.400000000001 5205.9 7632.7 True False 9741.79747730464 8863.629212995524 9621.891113585692 9559.008436680246 8879.84741877999 8497.850741829987 8692.984484245351 9024.51887749694 8834.03207610769 8612.431393793948 1.1311320847588413 1.0291668876901112 1.1172096094163553 1.10990822447287 1.0310500035075738 0.9866958995985121 1.0093531183899416 1.0478479844843744 1.0257303277299166 1.0 13.072204870086857 -6.360622196906674 4.969109448544319 1.0160517966472131 1.0932587855039595 0.6396286005446524 0.029543954844405286 0.15646779265647093 6.128937394979505 0.009378798998776116 0.010689303476247648 4.3589090065532647e-07 6.360622196906674 0.07720698885674637 LGGAVPFAPPEVS(ph)PEQAK ddPTM_A459_Selumetinib_30min_R2 10 LGGAVPFAPPEVSPEQAK 18 0 A0A096LP25;A0A096LNZ0;Q6ZSR9 A0A096LP25 AAK1 Uncharacterized protein FLJ45252 1 LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK;LGGAVPFAPPEVS(1)PEQAK 191.47 2.4085e-10 50812900.0 368699.5 362611.3 372190.0 416829.0 414272.0 326300.8 363585.3 342819.5 293250.5 391464.0 True False 348208.6578110403 390422.420730901 348243.70060983166 360056.1711298679 362227.4477213304 371245.7733362543 380492.7368806037 343817.0479881762 351908.7941035721 380161.4171743804 0.9159494942942005 1.026991175571649 0.9160416730298855 0.9471139228332311 0.9528253824747721 0.9765477414715221 1.0008715237561083 0.9043975334047826 0.9256825606322674 1.0 18.53625259380955 -5.342209596272899 19.54576450221609 0.9518652935540762 0.9716033483900046 0.03317676574717254 0.03967230263266552 45.27571303030329 10951.93445732952 0.010226255262917353 0.021287748856070376 4.547685298603994e-06 5.342209596272899 0.019738054835928387 LGGLRPES(ph)PESLTSVSR ddPTM_A459_Selumetinib_30min_R1 4 LGGLRPESPESLTSVSR 17 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 LGGLRPES(0.993)PES(0.006)LT(0.001)SVSR;LGGLRPES(0.881)PES(0.014)LT(0.038)S(0.064)VS(0.003)R;LGGLRPES(0.993)PES(0.007)LTSVSR;LGGLRPES(0.93)PES(0.069)LT(0.001)S(0.001)VSR 245.04 1.3599999999999998e-22 2252910000.0 10820.0 10798.8 10992.8 10784.099999999999 11255.900000000001 9635.0 9873.1 10554.3 5287.9 8412.51 True False 11072.084947944975 9534.471475774073 9500.038139128137 8900.859377628412 10237.805832390555 9538.080647880048 9128.364118121588 10274.365678801983 8973.180087064648 9492.337603286593 1.1664234259969237 1.0044387246059276 1.0008112370380589 0.9376888759778846 1.0785336826669392 1.0048189441321196 0.9616560745754572 1.0823851940584819 0.9453077273566214 1.0 13.21254769681699 -4.761443336842861 9.333294023942017 1.0034647997812607 1.1673905330980985 0.5332641707189787 0.04619668017389219 0.059986401563424566 82.8514458570759 0.01088493184606489 0.062025497490336534 1.7320349976301754e-05 4.761443336842861 0.1639257333168378 LGGLRPES(ph)PESLTSVSR ddPTM_A459_Selumetinib_30min_R2 3 LGGLRPESPESLTSVSR 17 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 LGGLRPES(0.974)PES(0.026)LTSVSR;LGGLRPES(0.958)PES(0.039)LT(0.003)SVSR;LGGLRPES(0.761)PES(0.092)LT(0.035)S(0.014)VS(0.098)R 250.1 7.5059e-30 1546530000.0 169774.0 170012.0 173732.0 181457.0 193136.0 148657.0 138059.0 138211.0 139786.0 148908.0 True False 160338.64073916982 183051.37372525898 162554.2722650998 156742.24356921506 168872.52902225312 169133.15237611305 144479.01705871863 138613.1711279372 167747.10594717477 144608.63913055227 1.1087763615174924 1.2658398199847571 1.1240979324779226 1.0839064976450585 1.1677900437870483 1.169592310618594 0.999103635352542 0.9585400427065608 1.1600074999373526 1.0 17.141794218001777 -7.258181679336772 24.692503327099708 1.0259577950638057 1.1546201488500976 0.45146011178487444 0.06686594003472819 221.12457302482383 1676076.4799417998 0.02620657405064579 0.01941982324687398 5.518465358487766e-08 7.258181679336772 0.12866235378629187 LGGLRPESPES(ph)LTSVSR ddPTM_A459_Selumetinib_30min_R1 1 LGGLRPESPESLTSVSR 17 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 LGGLRPES(0.211)PES(0.664)LT(0.062)S(0.062)VSR 147.53 0.0018187 76272000.0 2366.4 2705.2 2276.3 2794.1 2660.5 2273.6 2743.5 2404.7 1328.5 1814.4 True False 2421.532515787154 2388.473926386638 1967.1909628208816 2306.162886752863 2419.8582447494246 2250.729648263631 2536.5555861954795 2340.9195444335614 2254.3674701990185 2047.2959137526364 1.182795559508812 1.1666481187903277 0.9608728028060562 1.1264433593899628 1.1819777632017503 1.0993670397837636 1.2389784833527284 1.1434202201589516 1.1011439309068056 1.0 10.999503927545735 -5.024928323542678 24.991439522946596 1.115810624059446 1.1787588467817012 0.1052854908310763 0.07638284115168784 1619.832090344389 1623939.7806406482 0.01979955082468123 0.05294930603684262 9.442166980293486e-06 5.024928323542678 0.06294822272225509 LGGLRPESPES(ph)LTSVSR ddPTM_A459_Selumetinib_30min_R2 1 LGGLRPESPESLTSVSR 17 1 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 LGGLRPES(0.171)PES(0.388)LT(0.388)S(0.052)VSR 134.02 0.0027756 421370000.0 25384.0 42768.0 32269.0 43087.0 28856.0 23339.0 29005.0 31018.0 28186.0 33392.0 True False 23973.258900203127 46048.16807920543 30192.847671830725 37218.476270779196 25230.85130408693 26553.73539965223 30353.789972317143 31108.257244693672 33823.98758264107 32427.886197164677 0.7392791116400064 1.4200175675721856 0.9310766507645702 1.1477305688223793 0.7780603136041899 0.8188549582974035 0.9360397340660187 0.9593057362898237 1.0430524942941999 1.0 14.984947364728967 LGGPEGPGS(ph)PLLAT ddPTM_A459_Selumetinib_30min_R1 3 LGGPEGPGSPLLAT 14 0 Q9C086 Q9C086 INO80B INO80 complex subunit B 1 LGGPEGPGS(0.99)PLLAT(0.01);LGGPEGPGS(0.999)PLLAT(0.001);LGGPEGPGS(0.981)PLLAT(0.019) 122.55 0.0017582 20968900.0 14134.900000000001 16444.1 16700.7 16959.5 16352.499999999998 14282.3 15171.8 13836.900000000001 8586.2 12187.5 True False 14464.215668272405 14518.81712734531 14432.836670378538 13997.841694243294 14873.419262268359 14138.63302929084 14027.37891111375 13469.900463414446 14570.154288763872 13751.88434130305 1.0517988160233362 1.0557692871033548 1.0495170197898105 1.017885356423594 1.0815549995280893 1.0281233232035127 1.0200332233004075 0.9794948916897388 1.0595023872476292 1.0 13.747341695902566 -6.991487427220367 24.913740730287994 1.014624491941719 1.050121325149035 0.35107357968816255 0.02356598531764188 209.36832913830997 612755.028215455 0.007961443817725075 0.007010154117394378 1.0197942825547397e-07 6.991487427220367 0.03549683320731578 LGGPEGPGS(ph)PLLAT ddPTM_A459_Selumetinib_30min_R2 1 LGGPEGPGSPLLAT 14 0 Q9C086 Q9C086 INO80B INO80 complex subunit B 1 LGGPEGPGS(0.992)PLLAT(0.008) 74.392 0.046445 4324000.0 58939.0 49852.0 56897.0 67513.0 62458.0 47609.0 56986.0 60562.0 50396.0 53952.0 True False 55663.40633151088 53675.488100555296 53236.30896476963 58317.61293357902 54611.467658395544 54166.70759852788 59635.96191561682 60738.225393421155 60476.608181891024 52394.26557586937 1.062395010593433 1.0244534876212865 1.0160712890932873 1.113053352167564 1.0423176478982334 1.0338289315286218 1.138215437513121 1.1592533023574751 1.1542600610427116 1.0 15.677121300511216 -7.262740362748449 24.986071317592437 1.126203311512735 1.0487388595303193 0.2755275362913099 0.0491877861858459 127.78754849327994 2454184.1449774946 0.019158365182968616 0.013691163115243895 5.460842328088003e-08 7.262740362748449 -0.0774644519824157 LGGS(ph)AVISLEGKPL ddPTM_A459_Selumetinib_30min_R1 2 LGGSAVISLEGKPL 14 1 P23528;G3V1A4;E9PK25 P23528 CFL1 Cofilin-1 1 LGGS(0.996)AVIS(0.004)LEGKPL;LGGS(0.972)AVIS(0.028)LEGKPL 128.95 0.0051868 94660000.0 5329.7 7845.6 7337.0 8428.7 7823.7 6333.1 7370.4 6291.9 3631.5 5471.200000000001 True False 5453.871640209088 6927.033504679511 6340.675699256158 6956.785771294462 7116.047716386427 6269.394763994719 6814.44479405692 6125.018373028454 6162.3902657340905 6173.481814001004 0.8834352808556278 1.1220626727966554 1.0270825913629438 1.1268820385146325 1.1526797892637755 1.015536281288817 1.1038251993554526 0.9921497394124272 0.9982033561285045 1.0 12.591868676629495 -7.779089013828187 24.731804212796057 0.9963823577854908 1.0668751889164436 0.1395670631210164 0.07299169137294036 411.5525047479382 576684.5230258828 0.03868993426144914 0.018654234956685486 1.6630717490669048e-08 7.779089013828187 0.07049283113095284 LGGS(ph)AVISLEGKPL ddPTM_A459_Selumetinib_30min_R2 1 LGGSAVISLEGKPL 14 1 P23528;G3V1A4;E9PK25 P23528 CFL1 Cofilin-1 1 LGGS(1)AVISLEGKPL 137.93 0.0027671 15004000.0 74572.0 70808.0 97007.0 91870.0 82051.0 71957.0 60135.0 63710.0 54803.0 83118.0 True False 70427.5867753683 76238.74591639478 90765.67523323577 79357.14751541025 71743.0198347532 81868.42358939009 62931.39665524189 63895.385552241685 65765.13132375925 80718.16737350074 0.8725122121453073 0.9445054118191424 1.1244764120231199 0.9831386179545833 0.8888088291546864 1.0142502766516845 0.7796435263952967 0.7915861773296173 0.8147500552068967 1.0 16.300605799395406 -7.259257545834141 24.937110265435926 0.8291271193084301 0.9738183904378798 0.3221105428268024 0.08719544653584628 203.39717715062224 2324729.86343197 0.03477932434407807 0.02560831625529675 5.504811525984317e-08 7.259257545834141 0.14469127112944968 LGGS(ph)LIVAFEGCPV ddPTM_A459_Selumetinib_30min_R1 2 LGGSLIVAFEGCPV 14 0 P60981;P60981-2 P60981 DSTN Destrin 1 LGGS(1)LIVAFEGCPV;LGGS(1)LIVAFEGCPV 112.5 0.0035941 9196100.0 1223.12 1584.95 2175.3 2064.3 1805.51 1706.1799999999998 1724.3600000000001 1711.59 1060.37 1384.17 True False 1251.6163162227783 1399.3833171767353 1879.9062080675922 1703.8087567101882 1642.20193928868 1689.0173782874917 1594.2901369097992 1666.1930731721377 1799.3704436393932 1561.8417024575538 0.8013720687911992 0.8959828098934799 1.2036470822296297 1.090897210664339 1.051452228932471 1.0814267384651257 1.0207757510900035 1.0668130262819768 1.1520824682860553 1.0 10.60903252389592 -5.072867562149809 5.27131159521791 1.0821073096198448 0.8211079409608327 0.7412098220088759 0.056654202686349 0.09096732418309457 4.580355789378651 0.014456348851122592 0.04210028947460906 8.455366517605087e-06 5.072867562149809 -0.2609993686590121 LGHDPYRLT(ph)PDPYR ddPTM_A459_Selumetinib_30min_R1 2 LGHDPYRLTPDPYR 14 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-6 P18583-10 SON Protein SON 1 LGHDPYRLT(0.999)PDPY(0.001)R;LGHDPY(0.001)RLT(0.98)PDPY(0.019)R 69.729 0.033869 8123900.0 2897.1000000000004 3358.7 3667.5 3467.8 3630.8 2706.2 3167.8 3125.7 1537.08 2673.7 True False 2964.596793224713 2965.4618425827325 3169.4736441354753 2862.2138286681165 3302.3947810698023 2678.978085033003 2928.850295589587 3042.7962822954946 2608.3124961185617 3016.8954390434437 0.9826647469640801 0.9829514819124725 1.05057457514683 0.9487282163069027 1.0946334892258913 0.8879916918441221 0.9708159778047286 1.0085852638168538 0.8645684110767757 1.0 11.55884898042162 -6.776872495025261 24.999839283453717 0.9484553561609392 1.0089395720735255 0.25275506787143154 0.056154632275850276 369.53404396037047 598598.3258652975 0.018790927066307975 0.01663305807984947 1.6715813035931555e-07 6.776872495025261 0.06048421591258624 LGHDPYRLT(ph)PDPYR ddPTM_A459_Selumetinib_30min_R2 3 LGHDPYRLTPDPYR 14 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-6 P18583-10 SON Protein SON 1 LGHDPY(0.001)RLT(0.993)PDPY(0.006)R;LGHDPY(0.001)RLT(0.979)PDPY(0.02)R;LGHDPY(0.001)RLT(0.995)PDPY(0.005)R 71.344 0.031227 18100900.0 61506.0 54860.0 62296.0 68744.0 70328.0 51593.6 53092.9 54626.0 58102.0 59468.0 True False 58087.74274802612 59067.58559729728 58287.943182756404 59380.94860998549 61492.76789970292 58700.15007993045 55561.82505158552 54784.952616178896 69724.02350552098 57751.00432358023 1.0058308669847391 1.02279754766411 1.0092974808917208 1.0282236526532533 1.0647913160982883 1.0164351385307888 0.9620927930581312 0.9486406904582564 1.207321401976936 1.0 15.817558415602814 -8.24433045225102 24.984649568133225 1.1036607430171452 1.009265548606846 0.32310397706320615 0.05574995240962872 810.6715916520101 1183851.2522712261 0.0364928252480124 0.013719537838221472 5.697306024728046e-09 8.24433045225102 -0.0943951944102992 LGHPEALSAGTGS(ph)PQPPSFTYAQQR ddPTM_A459_Selumetinib_30min_R1 3 LGHPEALSAGTGSPQPPSFTYAQQR 25 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 LGHPEALSAGTGS(1)PQPPSFTYAQQR;LGHPEALSAGT(0.015)GS(0.985)PQPPSFTYAQQR;LGHPEALSAGT(0.01)GS(0.99)PQPPSFTYAQQR 244.74 8.6878e-46 151337000.0 5120.16 6320.860000000001 6676.97 7773.4 7187.6 5826.71 6214.55 5232.610000000001 3052.81 4804.7 True False 5239.449765902951 5580.810772711909 5770.274147970886 6415.921614789988 6537.482849073845 5768.09858762939 5745.781490137089 5093.8241848872985 5180.395601579425 5421.430046741231 0.9664331589139167 1.0293982813753135 1.0643454030066 1.183437129959195 1.2058594859124783 1.0639441139882526 1.0598276544379324 0.9395720577357899 0.9555404306458423 1.0 12.404457735727627 -7.639141583698711 3.8538631432287587 0.9607249278651105 1.0902069171948428 0.3920996562284169 0.0668523002813841 0.251641738099557 6.965407154410405 0.03882133744620594 0.020950382387371656 2.2954002061093842e-08 7.639141583698711 0.1294819893297322 LGHPEALSAGTGS(ph)PQPPSFTYAQQR ddPTM_A459_Selumetinib_30min_R2 5 LGHPEALSAGTGSPQPPSFTYAQQR 25 0 Q15942;Q15942-2;H0Y2Y8;H7C3D3 Q15942 ZYX Zyxin 1 LGHPEALSAGTGS(1)PQPPSFTYAQQR;LGHPEALSAGT(0.212)GS(0.78)PQPPS(0.005)FT(0.002)Y(0.001)AQQR;LGHPEALSAGT(0.001)GS(0.999)PQPPSFTYAQQR;LGHPEALSAGT(0.004)GS(0.988)PQPPS(0.007)FT(0.001)YAQQR;LGHPEALSAGT(0.001)GS(0.998)PQPPS(0.001)FTYAQQR 156.31 5.3603e-13 414176200.0 53914.2 50237.2 54793.9 65201.4 68342.0 56600.7 44336.9 48385.5 46933.6 49149.8 True False 50917.864599642766 54090.23170194204 51268.52012908749 56320.85684131137 59756.26697476812 64396.93265500219 46398.65370190064 48526.293794349265 56321.63143435193 47730.717567483414 1.0667734992178413 1.133237346064771 1.0741200371983137 1.179970880632224 1.2519457075054978 1.3491716851722473 0.9720921047604313 1.0166680131246935 1.179987109029366 1.0 15.54263040509247 -7.300547676547643 24.999978209349052 1.0435758179386863 1.1729515948325697 0.3316848771581007 0.09289910805657194 743.5520598491005 475312.7816538095 0.04176102854410432 0.028155645548323935 5.005555988652859e-08 7.300547676547643 0.12937577689388347 LGHS(ph)HLSYLSVRGGFNMSSFK ddPTM_A459_Selumetinib_30min_R2 1 LGHSHLSYLSVRGGFNMSSFK 21 1 P05162 P05162 LGALS2 Galectin-2 1 LGHS(0.77)HLS(0.227)Y(0.001)LS(0.002)VRGGFNMSSFK 52.227 0.026366000000000004 54676000.0 38494.0 22668.0 26929.0 26183.0 19167.0 23898.0 53357.0 44980.0 29821.0 19300.0 True False 36354.6575836913 24406.562710891973 25196.417458078315 22616.8302318057 16759.070104845934 27189.732575555438 55838.206224889684 45110.88435316017 35786.03326835802 18742.75885257782 1.9396641588167902 1.3021862417834593 1.3443281032564147 1.2066969654627473 0.8941623928827823 1.4506793151113848 2.979188211516144 2.4068433418997843 1.9093258121621792 1.0 14.194045706611938 -7.03062226429382 23.918785990691028 2.1944848575338805 1.3129583030541496 0.30121681869175043 0.5243574213492167 409.5362972634091 319883.8145728024 0.19454023308113838 0.15093242865188686 9.319180761593306e-08 7.03062226429382 -0.8815265544797308 LGHVVMGNNAVS(ph)PYQQVIEK ddPTM_A459_Selumetinib_30min_R1 2 LGHVVMGNNAVSPYQQVIEK 20 0 P60228;H0YAW4;E5RGA2 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 LGHVVMGNNAVS(0.999)PY(0.001)QQVIEK;LGHVVMGNNAVS(1)PYQQVIEK 148.4 1.2614000000000003e-05 54640000.0 7899.1 8608.1 9797.3 10537.5 9453.2 7631.900000000001 8934.4 8208.4 4706.4 6973.4 True False 8083.133661026998 7600.259650202881 8466.880472716699 8697.323438373103 8598.159729098015 7555.130015210772 8260.47101487329 7990.686567359098 7986.417058144266 7868.5038166681215 1.027277084609684 0.9659091267266072 1.0760470694290083 1.105333827245437 1.0927312141457235 0.9601736481599565 1.0498147052270408 1.0155280792305335 1.0149854717267042 1.0 12.941873620333698 -6.751434911172163 24.999558204605073 1.011678025603797 1.052732488093656 0.22621894473749715 0.041672409181183916 397.83468038922797 994122.7448731485 0.015217035120695187 0.015046083355893223 1.7724136614114642e-07 6.751434911172163 0.041054462489859 LGIAVIHGEAQDAES(ph)DLVDGRHSPPMVR ddPTM_A459_Selumetinib_30min_R1 1 LGIAVIHGEAQDAESDLVDGRHSPPMVR 28 1 C9K0K7;I3L0S1;E7EPA1;O60256-4;O60256-3;O60256-2;O60256 C9K0K7 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 1 LGIAVIHGEAQDAES(0.516)DLVDGRHS(0.484)PPMVR 64.619 0.0004452 28607000.0 6875.1 7786.5 8448.5 8757.3 8153.3 7248.6 6887.8 6748.2 3712.2 5666.0 True False 7035.276453384146 6874.85296015436 7301.240104288626 7228.001949880409 7415.835454582026 7175.685665202213 6368.247700600408 6569.215814757161 6299.332271639293 6393.2862915136875 1.1004163011943675 1.0753238079264327 1.1420167612359449 1.1305612826184095 1.159941087641523 1.122378279027965 0.9960836118122045 1.0275178547028307 0.9853042683229896 1.0 12.642341983868967 -7.25881705137537 24.63206416738533 1.0045195836849503 1.1227161638036305 0.8605696431674614 0.023564653620037623 72.9727864787909 685451.9287275715 0.010113411412269575 0.0074683022736450316 5.510397756569071e-08 7.25881705137537 0.11819658011868017 LGIAVIHGEAQDAESDLVDGRHS(ph)PPMVR ddPTM_A459_Selumetinib_30min_R1 10 LGIAVIHGEAQDAESDLVDGRHSPPMVR 28 1 C9K0K7;I3L0S1;E7EPA1;O60256-4;O60256-3;O60256-2;O60256 C9K0K7 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 1 LGIAVIHGEAQDAES(0.027)DLVDGRHS(0.973)PPMVR;LGIAVIHGEAQDAES(0.024)DLVDGRHS(0.976)PPMVR;LGIAVIHGEAQDAES(0.016)DLVDGRHS(0.984)PPMVR;LGIAVIHGEAQDAES(0.033)DLVDGRHS(0.967)PPMVR;LGIAVIHGEAQDAES(0.326)DLVDGRHS(0.674)PPMVR;LGIAVIHGEAQDAES(0.053)DLVDGRHS(0.947)PPMVR;LGIAVIHGEAQDAES(0.017)DLVDGRHS(0.983)PPMVR;LGIAVIHGEAQDAES(0.108)DLVDGRHS(0.892)PPMVR;LGIAVIHGEAQDAES(0.014)DLVDGRHS(0.986)PPMVR;LGIAVIHGEAQDAES(0.02)DLVDGRHS(0.98)PPMVR 89.721 1.3621e-05 177520900.0 37673.600000000006 43231.5 45926.4 48542.2 44739.0 39106.90000000001 39867.9 37451.81 20669.0 32993.939999999995 True False 38551.3215799353 38169.93588222091 39689.84713565739 40065.21601994733 40692.365349311985 38713.52009222423 36860.63220516957 36458.46633817616 35073.78339596802 37229.03358719115 1.0355176555858567 1.025273347287572 1.066099313126218 1.076182005265159 1.0930277105907045 1.0398744303033378 0.9901044602417954 0.97930198087978 0.9421083497594561 1.0 15.184140545911777 -7.276966554213385 2.6973400877440854 0.9723006506960375 1.0592107428753066 0.7504572019852411 0.022379211219415926 0.14919725446966736 2.1589598555176455 0.011245047423185122 0.0074729305166831425 5.2848594984629514e-08 7.276966554213385 0.08691009217926904 LGIAVIHGEAQDAESDLVDGRHS(ph)PPMVR ddPTM_A459_Selumetinib_30min_R2 7 LGIAVIHGEAQDAESDLVDGRHSPPMVR 28 1 C9K0K7;I3L0S1;E7EPA1;O60256-4;O60256-3;O60256-2;O60256 C9K0K7 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 1 LGIAVIHGEAQDAES(0.198)DLVDGRHS(0.802)PPMVR;LGIAVIHGEAQDAES(0.113)DLVDGRHS(0.887)PPMVR;LGIAVIHGEAQDAES(0.011)DLVDGRHS(0.989)PPMVR;LGIAVIHGEAQDAES(0.187)DLVDGRHS(0.813)PPMVR;LGIAVIHGEAQDAES(0.04)DLVDGRHS(0.96)PPMVR;LGIAVIHGEAQDAES(0.217)DLVDGRHS(0.783)PPMVR;LGIAVIHGEAQDAES(0.059)DLVDGRHS(0.941)PPMVR 73.383 7.8507e-05 55030700.0 100254.4 95164.1 119447.0 117351.0 129122.9 92282.2 94360.1 88153.4 86685.1 112323.2 True False 94682.66179816132 102462.88046918968 111761.91006406043 101367.59135823367 112901.326928628 104993.23539559488 98748.03162099104 88409.91179941902 104024.54218406303 109080.13736527816 0.8680101078448057 0.9393358217552552 1.0245853439824868 0.9292946801009483 1.0350310299899401 0.962533032425533 0.9052796779152573 0.8105042213447121 0.9536524677789376 1.0 16.73502889659838 -7.266972846970884 6.975670208469671 0.901380687159496 0.9639210841556454 0.07345014345856493 0.06361174697155171 0.25280367852370533 81.07658187103776 0.025566238322662433 0.018199903108260716 5.407881331308521e-08 7.266972846970884 0.06254039699614933 LGIHEDS(ph)QNR ddPTM_A459_Selumetinib_30min_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 LGIHEDS(1)QNR 142.97 0.0011413 10718000.0 1484.6 1877.7 1621.0 1867.2 2537.1 1610.4 1962.3 2450.6 902.04 1434.4 True False 1519.1882914712673 1657.8580110809519 1400.8771035156374 1541.1285716849595 2307.6197529613855 1594.2008381262099 1814.2821311432072 2385.602127329348 1530.6959976050596 1618.5192122391868 0.9386285191940988 1.0243054259376636 0.8655301048775033 0.9521842929209602 1.4257598769982118 0.9849749240360681 1.1209518660165834 1.4739411860480287 0.9457385405313629 1.0 10.66045877547188 -6.057150948379152 24.999833878206534 1.1732688367948303 0.9439504536286087 0.27368053827439887 0.16934413813165522 337.08088528642656 147450.2630135779 0.04795248033401345 0.061906588110520765 8.76696053630879e-07 6.057150948379152 -0.22931838316622155 LGIHEDS(ph)QNR ddPTM_A459_Selumetinib_30min_R2 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 LGIHEDS(1)QNR 99.5 0.012189 3098100.0 37537.0 38224.0 38024.0 37625.0 41098.0 28432.0 37824.0 35757.0 30246.0 31227.0 True False 35450.84381251673 41155.65789046832 35577.57723740095 32500.410093254744 35934.90181921835 32348.249920001363 39582.89094683411 35861.046950109965 36296.04514385021 30325.39537251024 1.1690150574146405 1.3571350805132663 1.1731941760486253 1.0717225511498571 1.1849771908264415 1.0667049686456793 1.3052720487435334 1.1825417775960063 1.1968861311781058 1.0 14.888238834400312 -11.913063381028502 1.8478052852197686 2.9745521525346747e-06 1.1901145900101606 0.31249079710229577 0.08441847454739781 2207596.4921201994 196663.25293104167 9216792.024147099 0.02341261504775851 1.221621363474814e-12 11.913063381028502 1.190111615458008 LGIHEDS(ph)TNR ddPTM_A459_Selumetinib_30min_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 LGIHEDS(0.955)T(0.045)NR 144.7 0.00095209 9614600.0 1999.7 2420.3 3209.4 2963.5 2760.8 2266.6 2902.7 3110.5 1438.3 2157.8 True False 2046.289119261142 2136.930150833057 2773.581107972294 2445.9803567846943 2511.0861274588297 2243.800061908138 2683.7470020228234 3027.9994356720554 2440.690050724311 2434.7746487518966 0.8404429216108775 0.8776706098564319 1.1391531078221449 1.0046023594169349 1.0313423169351839 0.9215637525461935 1.1022568365407261 1.2436466911729407 1.0024295480386436 1.0 11.249572534106008 -5.163938712087235 5.975194061110156 1.0582282285911155 0.8517503911652032 0.4627053821464888 0.0848854968357084 0.2055945356235607 10.297752357623569 0.022730845111441283 0.06237761003524558 6.8558496981207405e-06 5.163938712087235 -0.2064778374259123 LGIHEDS(ph)TNR ddPTM_A459_Selumetinib_30min_R2 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 LGIHEDS(0.983)T(0.017)NR 139.76 0.0024203 0.0 14089.0 14167.0 14585.0 17602.0 14280.0 10554.0 11026.0 14935.0 9572.5 14133.0 True False 13305.989782735658 15253.563345915247 13646.61697894732 15204.577234856353 12486.018735180254 12007.717700326897 11538.730847604513 14978.458377377652 11487.267477997291 13724.943568056073 0.9694750085315103 1.1113753051354571 0.9942931212270298 1.1078061749007138 0.909731881465849 0.8748828467516684 0.8407124437626228 1.0913311448681695 0.8369628203596531 1.0 13.74451259695821 -6.275875145739867 24.368083133374686 0.9233894833082076 1.046751232934209 0.33875595294047955 0.08218607475540417 636.4754549401209 1074389.980672779 0.0245790701901745 0.028000389090736537 5.298157374319986e-07 6.275875145739867 0.12336174962600144 LGIHEDSQNR ddPTM_A459_Selumetinib_30min_R1 3 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ;; 221.68 7.0825e-08 67603000.0 35255.0 39681.8 41170.5 42651.6 43586.3 34679.6 39815.0 35487.8 16895.6 27755.9 False True 36076.37290571168 35035.83640843167 35579.77223336867 35203.29872969057 39643.926860786276 34330.754710557456 36811.722494759604 34546.54826337976 28670.599194199865 31318.640130360876 1.1519137726142383 1.1186895811120252 1.1360573794159399 1.1240366306825638 1.2658252943222368 1.0961764165895753 1.175393386862721 1.1030666759343004 0.9154484062801325 1.0 14.934733951061647 -8.121992988065692 4.292127747352084 0.9601295157438414 1.1511311358359264 0.7208125019060878 0.04768267479450981 0.11569064738006912 3.386584993908987 0.034291608698742815 0.012016890286552603 7.551044191623567e-09 8.121992988065692 0.191001620092085 LGIHEDSQNR ddPTM_A459_Selumetinib_30min_R2 5 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ;;;; 198.72 9.9332e-05 283959700.0 711028.0 658060.0 784785.0 882351.0 906163.0 672858.0 633230.0 716991.0 597423.0 752603.0 False True 671511.9102306026 708531.0860035999 734292.7875093013 762173.2716596264 792322.7027399953 765538.0819032171 662676.4497214409 719077.3251057509 716924.293393322 730873.3958925721 0.9187800705353697 0.9694306701892099 1.0046785005938728 1.0428253045506324 1.0840765407425712 1.0474291254893895 0.9066911635388694 0.9838603089767478 0.9809144749588061 1.0 19.479261994244183 -4.913997403288436 2.3276205867769817 1.0076391765737664 0.9102827038226399 0.2689667924801362 0.04496771711173703 0.6654022181864775 5.45803294571248 0.01351335095206929 0.1193956437516402 1.2189968874675104e-05 4.913997403288436 -0.09735647275112658 LGIHEDST(ph)NR ddPTM_A459_Selumetinib_30min_R2 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 LGIHEDS(0.416)T(0.584)NR 89.189 0.042289 5943600.0 36796.0 40452.0 47614.0 48863.0 53475.0 37011.0 35901.0 43208.0 37070.0 42348.0 True False 34751.02562605874 43554.53832631915 44550.567078203436 42207.77510662342 46756.99242743443 42108.929297593204 37570.46763648191 43333.72812653054 44485.035822341066 41125.30320668213 0.8450035116193944 1.0590691114769046 1.0832884770309672 1.0263213111038025 1.1369397616948693 1.0239177833162152 0.913560866595079 1.053699906083357 1.0816950235910487 1.0 15.327738695070012 -4.758594473902777 24.980055912359294 1.0429126591790372 0.8450032424749239 0.5253931527107407 0.05618027836974281 65.81059854713669 577750.3526236522 0.014644928749953089 0.09910622026822943 1.74343405967842e-05 4.758594473902777 -0.19790941670411333 LGIHEDSTNR ddPTM_A459_Selumetinib_30min_R1 4 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;;; 221.68 0.00023717 242152000.0 51764.4 60126.7 62113.0 67452.0 65868.0 52597.7 58868.0 52590.5 25740.1 42460.0 False True 52970.40980401134 53087.03801185553 53678.395762286746 55672.77443085582 59910.25102993994 52068.61489289055 54427.5393651013 51195.629101980754 43679.06971747818 47910.15459542379 1.1056196802393723 1.1080539910619747 1.1203970476733531 1.1620245207093005 1.250470835167423 1.0867970544570935 1.1360334740038602 1.0685757442091572 0.9116870961140722 1.0 15.548043848283609 -8.03177342187831 3.2448671468225667 0.9574034416355154 1.139496471099373 0.6984058283235235 0.04745513650880394 0.14298796025946325 2.9618877854550307 0.036807033668689974 0.013194025691330621 9.294511693032806e-09 8.03177342187831 0.18209302946385753 LGIHEDSTNR ddPTM_A459_Selumetinib_30min_R2 4 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;;; 194.94 0.00017961 190726600.0 428909.0 399188.0 476613.0 556324.0 592641.0 396967.0 386829.0 416022.0 379860.0 470971.0 False True 405071.9548387654 429804.4360082747 445948.2384769982 480551.71148756985 518188.13930223836 451645.60094235995 404817.31498712173 417232.5551438501 455842.6141751951 457372.8435003855 0.8856493353183177 0.9397244329568779 0.975021243202915 1.050678277725872 1.1329665647317813 0.9874779566836684 0.8850925907383491 0.9122372722233965 0.9966543065533161 1.0 18.80301118275218 -10.449296974243605 14.78258969692216 1.0000259745281 0.9758514064239332 0.010878621589546666 0.0725109325189571 0.0 0.0 0.0787525938136175 0.019100309563818176 3.553882179890463e-11 10.449296974243605 -0.024174568104166738 LGIHEDSTNRR ddPTM_A459_Selumetinib_30min_R1 3 LGIHEDSTNRR 11 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;; 107.21 0.0072063 58681000.0 18814.800000000003 21304.7 24215.1 26022.8 25990.6 20005.1 22352.300000000003 20105.1 8642.900000000001 14840.699999999999 False True 19253.1482327722 18810.33581971367 20926.822424023158 21478.4064884551 23639.75481901313 19803.86685717749 20666.248015060024 19571.847437431345 14666.370047559734 16745.64840565959 1.14974038426993 1.123296952380552 1.2496871973587143 1.2826261466946818 1.4116953996850616 1.1826276521179258 1.2341264736022628 1.1687721468472114 0.8758317201143961 1.0 14.031498619046966 -8.133281914296568 4.160264219045268 0.9405814298101135 1.2347962610584797 0.6752445199027621 0.080532683161131 0.14218776505454184 3.965322589880001 0.0652533058286651 0.0225865098976549 7.3572935723674545e-09 8.133281914296568 0.2942148312483662 LGIHEDSTNRR ddPTM_A459_Selumetinib_30min_R2 6 LGIHEDSTNRR 11 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;;;;; 114.86 0.0042817 70622500.0 207834.0 215407.0 246559.0 291517.0 311946.0 192915.0 183840.0 208872.0 195618.0 251083.0 False True 196283.41830542157 231928.02425732816 230695.6623731411 251811.88170512562 272756.55464737635 219487.29014198997 192388.92427204928 209479.7829393792 234747.06602359653 243833.581398021 0.8049892766206758 0.9511734311884676 0.9461193206056624 1.0327202687232866 1.1186176780225487 0.9001520171403732 0.7890173419468577 0.8591096506819359 0.9627347663831746 1.0 17.895537305809476 -6.972869294780453 24.995282664131096 0.8843473280729574 0.975482139616204 0.10958734204573917 0.09139462138553897 391.92515251792713 361076.1388584112 0.03366129279019244 0.02968588573811368 1.0644633307883373e-07 6.972869294780453 0.09113481154324665 LGKS(ph)Y(ph)T(ph)MIGK ddPTM_A459_Selumetinib_30min_R1 1 LGKSYTMIGK 10 1 B7WPD9;A0A0G2JR66;Q2KJY2-2;Q2KJY2 B7WPD9 KIF26B Kinesin-like protein;Kinesin-like protein KIF26B 3 LGKS(1)Y(1)T(1)MIGK 80.834 0.038668 0.0 784.6 913.92 1034.1 949.38 958.48 606.41 742.36 906.24 494.22 623.74 True False 802.8796534341614 806.9178215301191 893.6748999047019 783.5886050697666 871.7856532333884 600.3100659762264 686.363187522535 882.2035713176157 838.6552435993668 703.8031047421018 1.1407731054672807 1.1465107444017346 1.2697797066868237 1.113363382159135 1.2386783282987097 0.8529517160857099 0.9752204599524217 1.253480647319517 1.1916049218150004 1.0 9.45902806815067 LGLAVIHGEAQCTELDMDDGRHS(ph)PPMVK ddPTM_A459_Selumetinib_30min_R1 1 LGLAVIHGEAQCTELDMDDGRHSPPMVK 28 1 C9JUN4;C9J168;B4DP31;Q14558;Q14558-2 C9JUN4 PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1 1 LGLAVIHGEAQCT(0.24)ELDMDDGRHS(0.76)PPMVK 66.906 0.00034949 40783000.0 1923.4 2374.3 2121.1 2090.2 2263.4 1950.9 1658.9 1906.1 1076.2 1606.0 True False 1968.2114777150982 2096.3158522178774 1833.0662703683035 1725.185807913402 2058.675869635727 1931.275717275474 1533.7678374119478 1855.5440361146136 1826.2327974619375 1812.1457437647339 1.0861220652297743 1.1568141577082978 1.01154461592041 0.9520127251626723 1.136043211049254 1.0657397308801706 0.8463821647289496 1.0239485662227805 1.0077736869375296 1.0 10.823483275008183 -7.069529192761517 24.99953389896551 0.9693129606557224 1.067489403335071 0.3177971106813616 0.0707165799545433 218.59896239839176 78597.14031449093 0.027971394588527224 0.021666555828763354 8.520612349055814e-08 7.069529192761517 0.09817644267934866 LGLAVIHGEAQCTELDMDDGRHS(ph)PPMVK ddPTM_A459_Selumetinib_30min_R2 2 LGLAVIHGEAQCTELDMDDGRHSPPMVK 28 1 C9JUN4;C9J168;B4DP31;Q14558;Q14558-2 C9JUN4 PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1 1 LGLAVIHGEAQCT(0.015)ELDMDDGRHS(0.985)PPMVK;LGLAVIHGEAQCT(0.137)ELDMDDGRHS(0.863)PPMVK 53.381 0.005109000000000001 9515700.0 32966.0 35091.0 34422.0 44936.0 33556.0 27778.0 25481.0 30282.0 27761.0 32872.0 True False 31133.881693353953 37782.36686465106 32207.325995839874 38815.63928107631 29340.395285553815 31604.167356422255 26665.91698964362 30370.115606545016 33313.9757071489 31922.89994828694 0.9752836284857846 1.183550583620413 1.0089097810040342 1.2159183327315242 0.9191018150945992 0.990015550204367 0.8353225124547176 0.9513582931294671 1.0435761087218083 1.0 14.962304094736789 -6.2861401820568545 24.976448781370934 0.9497409501267938 1.0959605404601733 0.39422054573175314 0.0843733705695451 725.8699363258165 733968.1471886843 0.024970082981681296 0.028326796180696327 5.174397852017383e-07 6.2861401820568545 0.1462195903333795 LGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSR ddPTM_A459_Selumetinib_30min_R1 1 LGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSR 34 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 195.58 1.2133999999999999e-50 20441000.0 806.1 1034.2 867.4 707.36 1074.6 1091.1 749.61 928.56 456.48 949.95 False True 824.8805616024441 913.1153832134645 749.6118442871467 583.8328547917063 977.4026197360388 1080.1245246395347 693.0663141855266 903.9315724120371 774.6132200199079 1071.8853357965818 0.7695604502224357 0.8518778573781627 0.6993395834919838 0.5446784607402296 0.9118537096224688 1.007686632672169 0.6465862448528301 0.8433099532425936 0.7226642572213628 1.0 10.065934867392976 -6.322490134259992 24.999982689274397 0.8446942448939958 0.7248244587488653 0.2203814146616777 0.1267213067733462 445.0640660710131 182250.15752098715 0.04067082708239183 0.04611639406903371 4.7589360160100073e-07 6.322490134259992 -0.11986978614513055 LGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSR ddPTM_A459_Selumetinib_30min_R2 2 LGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSR 34 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ; 191.48 6.292599999999998e-49 5702000.0 64022.0 60949.0 76835.0 70869.0 86673.0 61895.0 60373.0 63235.0 61054.0 67636.0 False True 60463.9135403721 65623.59231807647 71891.51975162273 61216.51994415608 75784.3628735489 70420.47442313188 63180.46412682999 63419.003380882175 73266.5059912925 65683.17294056762 0.9205388660971345 0.9990929088863435 1.0945195935749426 0.931996997154003 1.153786570909435 1.0721235176450858 0.9618972607184771 0.9655289253195162 1.1154532083519557 1.0 16.003236200256154 -4.847979522793126 3.6186447241583855 1.0353265801906169 0.9152395158230511 0.20681400267576044 0.06902948205917943 0.39960938612835034 8.766649891058673 0.01733248544097834 0.11512424959562853 1.419124432554225e-05 4.847979522793126 -0.12008706436756578 LGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASR ddPTM_A459_Selumetinib_30min_R1 2 LGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASR 34 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 171.49 3.5774999999999997e-35 37809000.0 5226.799999999999 6176.1 6088.8 6375.299999999999 6333.2 4965.1 5642.4 5266.3 2704.8 4791.0 False True 5348.574270417631 5452.999340809009 5261.974403384342 5261.973534202612 5760.363178217275 4915.1556019500995 5216.7892252776965 5126.620616646759 4589.84804922417 5405.971518291933 0.989382621110731 1.0086992360869735 0.9733633234247804 0.9733631626429994 1.0655555913911503 0.9092085641440983 0.9650049408558464 0.9483254951122204 0.8490329691330626 1.0 12.400338195623258 -6.787878983608127 24.999965904178527 0.9330028877331874 0.9992510242802379 0.37208615832713243 0.043918066596105795 247.9807237729027 234476.44998997977 0.0150450661771994 0.013272270580417782 1.6297501001190685e-07 6.787878983608127 0.06624813654705053 LGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASR ddPTM_A459_Selumetinib_30min_R2 2 LGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASR 34 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 99.907 4.2685000000000006e-11 10604500.0 34909.0 33374.0 37558.0 41244.0 52626.0 37309.0 33792.0 36535.0 36222.0 42016.0 False True 32968.89753179923 35933.67848567626 35141.55917005849 35626.49605013155 46014.65139759072 42447.97609261854 35363.39495757772 36641.31080130516 43467.41212724135 40802.88890932174 0.8080040019976926 0.8806650569652908 0.8612517424478278 0.873136608765768 1.127730232529646 1.0403179095223567 0.8666885091437405 0.8980077582921873 1.0653023177805157 1.0 15.31638368046202 -6.033597093863706 24.47176062002194 0.990910081803864 0.8554012786532093 0.47966850165527264 0.07332022064583477 489.4559112306058 356513.60636007343 0.02333879839289385 0.030152852730598825 9.255564382203415e-07 6.033597093863706 -0.13550880315065472 LGLHS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 LGLHSLR 7 0 P61204-2;P84077;P61204;H0YGG7 P61204-2 ARF3;ARF1 ADP-ribosylation factor 3;ADP-ribosylation factor 1 1 LGLHS(1)LR 74.165 0.037437 5442700.0 36750.0 29458.0 36993.0 35127.0 39789.0 28423.0 28792.0 33282.0 29861.0 32872.0 True False 34707.582121906154 31717.33387760085 34612.91065493302 30342.642002545115 34790.35010182681 32338.01025169525 30130.885050265653 33378.845109868285 35834.034386051404 31922.89994828694 1.0872314914412606 0.993560545219291 1.0842658627820068 0.9504976694378724 1.0898242377160268 1.013003527376296 0.9438642823514081 1.0456081735663076 1.122518143530201 1.0 14.962304094736789 LGLHVTPSNVDQVS(ph)TPPAAK ddPTM_A459_Selumetinib_30min_R1 1 LGLHVTPSNVDQVSTPPAAK 20 0 Q9NRL2;Q9NRL2-2 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 LGLHVTPSNVDQVS(0.603)T(0.397)PPAAK 132.65 9.3832e-05 22699000.0 3494.8 4977.4 4214.1 4736.7 4979.6 4203.1 5044.1 3920.8 1418.6 2738.9 True False 3576.2220403029673 4394.643694069518 3641.848366394354 3909.5242638711193 4529.196059219787 4160.8206301094615 4663.619475971792 3816.807647446711 2407.260589555384 3090.4644941452257 1.1571794618828308 1.4220010300700794 1.178414563019153 1.2650280471681759 1.4655389401173144 1.3463415088547328 1.5090351255634393 1.2350271794668783 0.778931644131765 1.0 11.59360797490754 -8.134210089375962 4.869043583502231 0.8961432469103376 1.3369875500178807 0.6824061561481727 0.11941337743467052 0.12234821187171313 4.1932119758008914 0.08482474322932704 0.030326850122259944 7.341586339827156e-09 8.134210089375962 0.4408443031075431 LGLHVTPSNVDQVS(ph)TPPAAK ddPTM_A459_Selumetinib_30min_R2 2 LGLHVTPSNVDQVSTPPAAK 20 0 Q9NRL2;Q9NRL2-2 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 LGLHVTPSNVDQVS(0.595)T(0.405)PPAAK;LGLHVTPSNVDQVS(0.5)T(0.5)PPAAK 131.41 0.00010322 31622000.0 94565.0 104472.0 131576.0 145742.0 168038.0 122464.0 104289.0 118648.0 110514.0 150598.0 True False 89309.45587368862 112484.66646957402 123110.5434091173 125891.68818102666 146927.56416121984 139332.30438249328 109138.645144733 118993.24603676626 132619.88801915845 146249.84443940516 0.6106635956846551 0.769126742669317 0.8417823887677703 0.8607987835035724 1.0046339859328566 0.9527005304967829 0.7462479400444886 0.8136298981573825 0.90680361765517 1.0 17.158075564591876 -4.73965631810402 1.3032145210920887 0.8893854938498271 0.4702113676566211 0.5804057077815616 0.07561772475163704 1.2021691814202096 1.6738361589468584 0.024174916275403958 0.6938290935417806 1.8211414612175263e-05 4.73965631810402 -0.41917412619320604 LGLHVTPSNVDQVST(ph)PPAAK ddPTM_A459_Selumetinib_30min_R1 1 LGLHVTPSNVDQVSTPPAAK 20 0 Q9NRL2;Q9NRL2-2 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 LGLHVTPSNVDQVS(0.429)T(0.571)PPAAK 137.23 0.00012957 23875000.0 2759.2 3422.3 3220.2 3772.6 4215.0 3346.4 4021.6 3193.7 1210.7 2286.4 True False 2823.483991531401 3021.615525015893 2782.9145272924484 3113.7862304727278 3833.753994218691 3312.7382542880946 3718.2474741912656 3108.9927014003665 2054.4694739706083 2579.881711421974 1.0944238175847056 1.1712225066902175 1.0786984980635284 1.20694922433342 1.4860192919874649 1.2840659475283407 1.4412472702641275 1.2050911821405788 0.7963425086021598 1.0 11.333089203699323 -8.179180333696412 5.877763481966576 0.900940626765 1.2546104783805652 0.5231940644512076 0.13303946674901757 0.17603840432283419 9.68257154368687 0.10127446284504345 0.036872062422442516 6.6194158618668636e-09 8.179180333696412 0.3536698516155652 LGLPLLTDCAQPS(ph)RPHGSPSR ddPTM_A459_Selumetinib_30min_R1 1 LGLPLLTDCAQPSRPHGSPSR 21 1 U3KQ90;P55199 U3KQ90 ELL RNA polymerase II elongation factor ELL 1 LGLPLLT(0.004)DCAQPS(0.421)RPHGS(0.421)PS(0.155)R 49.924 0.027468 18799000.0 2027.7 2070.8 2484.4 2689.7 2297.6 2381.1 2021.6 1940.0 1055.4 1323.6 True False 2074.9414647826284 1828.349773311198 2147.0321258323575 2219.9943869221497 2089.7824856742272 2357.148295865821 1869.109084400502 1888.5448979918945 1790.936716633831 1493.4969529557927 1.389317507930695 1.224207233695854 1.4375872154162401 1.486440519700117 1.399254602788657 1.5782745931960347 1.2514984250227843 1.2645120529066087 1.1991565922443783 1.0 10.544478578916046 -8.302965866699747 1.0249885931644371 1.0123110144092344 1.4077356321815484 0.6484512406050467 0.0943426035535881 0.3287827856361374 0.723379554796451 0.09388647401006087 0.031956863644907435 4.977762060770248e-09 8.302965866699747 0.39542461777231397 LGLPLLTDCAQPSRPHGS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 LGLPLLTDCAQPSRPHGSPSR 21 1 U3KQ90;P55199 U3KQ90 ELL RNA polymerase II elongation factor ELL 1 LGLPLLTDCAQPS(0.035)RPHGS(0.815)PS(0.15)R 61.437 0.0096619 12215000.0 24798.0 23358.0 25869.0 27359.0 26206.0 21695.0 19427.0 21801.0 20466.0 27465.0 True False 23419.826434259274 25149.483492192285 24204.616704037584 23632.65700309255 22913.767995387505 24683.28932239833 20330.393993870195 21864.437300650174 24559.77186781851 26672.014087360112 0.8780674139399899 0.9429165495271181 0.9074911487658583 0.8860469601465937 0.8590940271828349 0.9254377731487387 0.7622369247137127 0.8197520153159992 0.9208067972436098 1.0 14.70303915097499 -5.892997897224149 2.746952554302406 0.8684592266754971 0.9135246247624953 0.015012736139443983 0.0625977570354761 0.7098893724481081 10.825576758222834 0.018564612752900025 0.030032376154525704 1.2793874987069286e-06 5.892997897224149 0.045065398086998165 LGMLS(ph)PEGTCK ddPTM_A459_Selumetinib_30min_R1 1 LGMLSPEGTCK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 LGMLS(0.998)PEGT(0.002)CK 110.64 0.0087072 90266000.0 2528.9 3140.2 2989.5 3289.4 2591.2 2236.9 2735.7 1915.4 1349.1 1866.0 True False 2587.8184496171943 2772.543924160625 2583.5423201480558 2714.9680396853623 2356.826417513517 2214.3988169426975 2529.3439464752937 1864.5973699039555 2289.3241656345476 2105.5192763792006 1.2290642401846776 1.316798167209605 1.2270333257603308 1.2894529488014057 1.1193563715866244 1.0517114907400582 1.2012922298317457 0.8855760148206521 1.0872967022042328 1.0 11.039960368342628 -6.656932349333427 0.8342757966279244 1.0092037551703996 1.2841105726109734 0.6324123874726046 0.07862677846155447 0.37988092966306986 0.5826846108682188 0.04737119247939269 0.05015793032517511 2.2032696427568901e-07 6.656932349333427 0.27490681744057377 LGMLS(ph)PEGTCK ddPTM_A459_Selumetinib_30min_R2 4 LGMLSPEGTCK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 LGMLS(0.993)PEGT(0.007)CK;LGMLS(0.998)PEGT(0.002)CK;LGMLS(0.994)PEGT(0.006)CK;LGMLS(0.999)PEGT(0.001)CK 122.55 0.00412 85862000.0 279594.0 242828.0 287866.0 316267.0 327491.0 270779.0 288265.0 291308.0 231147.0 283807.0 True False 264055.2847834617 261452.12678491656 269345.0149648029 273190.8890089946 286348.65277331375 308076.34936297324 301669.8936862608 292155.65805136476 277382.85878679936 275612.75449085806 0.9580662740781116 0.9486212902878876 0.9772588916008854 0.9912127960611352 1.0389528354821176 1.1177869831607956 1.0945425738498145 1.0600222714332164 1.0064224324422548 1.0 18.072283127409847 -6.1598529515535425 2.2065536955008516 1.0628544933058817 0.960312049062243 0.5983446950760547 0.03427325983663962 0.21032926329839527 2.0100801084106443 0.011774132665763028 0.016271671244621415 6.920652587088586e-07 6.1598529515535425 -0.10254244424363868 LGNPYCS(ph)PTLVR ddPTM_A459_Selumetinib_30min_R1 3 LGNPYCSPTLVR 12 0 Q6ZV89-2;Q6ZV89 Q6ZV89-2 SH2D5 SH2 domain-containing protein 5 1 LGNPYCS(0.718)PT(0.282)LVR;LGNPY(0.001)CS(0.974)PT(0.025)LVR;LGNPYCS(0.5)PT(0.5)LVR 137.09 0.0013528 105623000.0 7202.4 7844.8 9667.599999999999 8955.699999999999 8444.5 7809.6 7462.0 7505.700000000001 3953.62 5633.71 True False 7370.201906569209 6926.327169051422 8354.793020325593 7391.7551143096625 7680.696465997564 7731.04251454946 6899.135332309334 7306.624454050388 6709.004379020131 6356.851555482452 1.1594107306490107 1.089584538603521 1.314297329016598 1.1628012782420034 1.2082548096271597 1.2161747756846455 1.0853069750164595 1.149409324770028 1.0553973646331203 1.0 12.634096683826405 -8.180600056573645 0.8836415315658844 1.0016847179005859 1.1905613059603268 0.5226448480257386 0.05941479321173944 0.4530686171919111 0.7267562325200932 0.056104300633527254 0.02093536038469583 6.597812105671345e-09 8.180600056573645 0.18887658805974095 LGNPYCSPT(ph)LVR ddPTM_A459_Selumetinib_30min_R2 3 LGNPYCSPTLVR 12 0 Q6ZV89-2;Q6ZV89 Q6ZV89-2 SH2D5 SH2 domain-containing protein 5 1 LGNPYCS(0.049)PT(0.951)LVR;LGNPYCS(0.105)PT(0.895)LVR;LGNPYCS(0.227)PT(0.773)LVR 160.46 0.0011062 89387000.0 138309.0 134364.0 153431.0 149609.0 174390.0 128872.0 115542.0 129307.0 104982.0 155664.0 True False 130622.33947479504 144669.28675164495 143559.41650304152 129231.99611007952 152481.56913361925 146622.948216461 120914.93194212948 129683.26196207368 125981.33344216364 151169.57585635647 0.8640782295963725 0.9570000175770276 0.9496581285605628 0.8548809863227879 1.0086789505747469 0.9699236594788375 0.7998628775476926 0.8578661495041873 0.8333775677314391 1.0 17.2058082887461 -7.248408491979698 24.97354004885167 0.8609321575549143 0.9355853631206504 0.16507676670501437 0.06530150834912624 1130.8973139554462 2167355.062060706 0.024222624580257587 0.018643834843137124 5.64405851954109e-08 7.248408491979698 0.07465320556573618 LGNSGAS(ph)PSSAGK ddPTM_A459_Selumetinib_30min_R1 2 LGNSGASPSSAGK 13 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 LGNS(0.015)GAS(0.753)PS(0.229)S(0.003)AGK;LGNS(0.006)GAS(0.984)PS(0.009)S(0.001)AGK 160.03 0.0003641 33569000.0 4871.1 7584.1 8752.6 9263.6 7123.3 6386.0 7283.400000000001 6479.4 3192.3999999999996 5087.3 True False 4984.587152489354 6696.150046247562 7564.044994590364 7645.886159308478 6478.998772720762 6321.762638024077 6734.007274101019 6307.545263942617 5417.269636329202 5740.304509498343 0.868348908013761 1.1665147789925787 1.317707968640744 1.3319652549193193 1.1286855535277127 1.101293951838898 1.1731097649886728 1.0988171887929767 0.9437251329376999 1.0 12.486911555132853 -8.077753652109024 3.240811718171516 0.9728598128481837 1.1652816687313199 0.25950327754145286 0.1211439966661348 0.3631438190761279 7.0539654066648545 0.09997775671907703 0.03410996785613688 8.360771376213145e-09 8.077753652109024 0.1924218558831362 LGNSGAS(ph)PSSAGK ddPTM_A459_Selumetinib_30min_R2 3 LGNSGASPSSAGK 13 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 LGNS(0.028)GAS(0.971)PS(0.001)SAGK;LGNS(0.001)GAS(0.996)PS(0.003)SAGK;LGNS(0.002)GAS(0.976)PS(0.02)S(0.001)AGK 147.53 0.0005707 74428000.0 296657.0 310201.0 329482.0 341238.0 324007.0 259459.0 266801.0 291127.0 224968.0 311239.0 True False 280169.99155206257 333992.4192465766 308283.4868328781 294760.79573161696 283302.34400066844 295197.1221157022 279207.77515615226 291974.1313713306 269967.8861311152 302252.7213739624 0.9269395169660757 1.105010461868908 1.0199527250954148 0.9752130415624081 0.9373028726188123 0.9766566228876706 0.9237560339802606 0.9659933913716044 0.8931859567844791 1.0 18.20539580347298 -5.882327047078135 3.222735744933565 0.9482486834654188 1.0265567003824925 0.273997348778795 0.04866078438266717 0.2735352868872868 5.625489902956604 0.013494506135679438 0.02143624043133487 1.3112121139691989e-06 5.882327047078135 0.07830801691707368 LGPELSPSPTS(ph)PTATSTTPSR ddPTM_A459_Selumetinib_30min_R1 1 LGPELSPSPTSPTATSTTPSR 21 0 M0QY76;P26651 M0QY76 ZFP36 Tristetraprolin 1 LGPELSPS(0.285)PT(0.294)S(0.41)PT(0.01)AT(0.001)STTPSR 154.48 4.3377e-07 5293100.0 1764.2 2152.8 2429.5 2227.8 2162.8 1963.0 1854.5 2000.3 1047.9 1686.8 True False 1805.302427464375 1900.7491751904324 2099.5872442882437 1838.7565509853011 1967.1751218733536 1943.2540022613948 1714.6135719334852 1947.2455461098903 1778.2097644121575 1903.3172108233832 0.9485031802362536 0.9986507579407429 1.1031199803946254 0.9660799264195415 1.0335508504241104 1.0209827301570686 0.9008553919352917 1.0230798812918334 0.9342687358156638 1.0 10.89430030888264 LGPELSPSPTS(ph)PTATSTTPSR ddPTM_A459_Selumetinib_30min_R2 1 LGPELSPSPTSPTATSTTPSR 21 0 M0QY76;P26651 M0QY76 ZFP36 Tristetraprolin 1 LGPELS(0.001)PS(0.189)PT(0.122)S(0.397)PT(0.29)AT(0.001)STTPSR 186.6 1.3146e-16 3510000.0 23985.0 18088.0 21681.0 19992.0 19849.0 13519.0 16486.0 19661.0 16477.0 21673.0 True False 22652.009719562408 19475.291437913114 20286.06806448794 17269.055111876394 17355.39116768857 15381.119536736715 17252.63166638926 19718.210254946232 19772.86040584605 21047.244176783377 1.0762458747235517 0.92531313241454 0.9638348799537818 0.820490082541324 0.8245920949039406 0.7307901883755021 0.8197097691972498 0.9368547297368667 0.939451276365052 1.0 14.361343725773969 -4.623189368073246 1.1194924129906936 0.8598160111294254 1.2261050018716468 0.3654352293688029 0.07790388445908622 2.432853854214115 2.0188334390031164 0.02565364492467076 1.1448377991799552 2.381280918501544e-05 4.623189368073246 0.36628899074222143 LGPGRPLPTFPTSECT(ph)SDVEPDTR ddPTM_A459_Selumetinib_30min_R1 3 LGPGRPLPTFPTSECTSDVEPDTR 24 1 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 LGPGRPLPT(0.001)FPT(0.039)S(0.124)ECT(0.416)S(0.416)DVEPDT(0.003)R;LGPGRPLPTFPT(0.003)S(0.102)ECT(0.447)S(0.447)DVEPDTR;LGPGRPLPTFPT(0.005)S(0.048)ECT(0.473)S(0.473)DVEPDTR 78.97800000000002 0.00041522 269131000.0 4071.8 4037.0 5224.0 5086.4 4438.5 4143.2 4080.7 4300.6 2146.08 4043.0000000000005 True False 4166.665017656408 3564.346163249616 4514.609493377975 4198.155723553115 4037.038458680821 4101.523169724608 3772.8895136095807 4186.534117682442 3641.741016518413 4561.958432154931 0.9133500621767396 0.7813192987744798 0.9896209184101247 0.9202529540739445 0.8849353887632523 0.8990707019193888 0.8270328565504667 0.9177054503990406 0.7982845680595482 1.0 12.155437585762563 LGPGRPLPTFPTSECT(ph)SDVEPDTR ddPTM_A459_Selumetinib_30min_R2 3 LGPGRPLPTFPTSECTSDVEPDTR 24 1 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 LGPGRPLPT(0.001)FPT(0.008)S(0.028)ECT(0.481)S(0.481)DVEPDTR;LGPGRPLPTFPT(0.129)S(0.129)ECT(0.371)S(0.371)DVEPDT(0.001)R;LGPGRPLPTFPTS(0.001)ECT(0.499)S(0.499)DVEPDTR 94.707 1.7032e-05 74624000.0 55379.0 51696.0 54491.0 58989.0 59990.0 45277.4 52393.0 49823.3 44775.3 53049.0 True False 52301.256879701745 55660.916971160754 50985.10838531492 50954.596438299144 52453.51988259544 51513.95086268537 54829.37831475994 49968.27755430868 53731.61112641129 51517.33753214513 1.0152166122146253 1.0804307760747567 0.9896689314253067 0.9890766658215818 1.0181721803823065 0.999934261558885 1.0642898282650612 0.9699312881441149 1.0429811341256625 1.0 15.652770414996821 -5.273587546481711 24.904090870299907 1.0094131108360236 1.0478236976292876 0.21130387868810652 0.029802861756957327 952.6723321288165 1953007.9715182874 0.007364441980399306 0.01551447850683936 5.326138474842614e-06 5.273587546481711 0.038410586793264034 LGPGRPLPTFPTSECTS(ph)DVEPDTR ddPTM_A459_Selumetinib_30min_R2 1 LGPGRPLPTFPTSECTSDVEPDTR 24 1 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 LGPGRPLPTFPTS(0.013)ECT(0.173)S(0.813)DVEPDTR 90.758 2.7882e-05 8105500.0 8555.0 7946.8 11620.0 11450.0 14928.0 9489.3 9362.8 9409.9 9343.2 11200.0 True False 8079.547348378418 8556.294007010603 10872.3818508994 9890.490247648293 13052.611181986756 10796.364939711208 9798.18875203623 9437.281251107199 11212.101070819985 10876.626898905266 0.7428357544554209 0.78666797036789 0.9996097091455539 0.9093343312754225 1.2000605797465116 0.9926206939026164 0.9008481069643401 0.867666174340968 1.0308435855190072 1.0 13.408943591401462 -5.205862001493216 4.1848543825090045 0.9852864397041523 0.7535171051073792 0.5125230570325321 0.08714958201453514 0.18613212606611476 6.78354553651051 0.0240204168585 0.06866354152728348 6.224980545604856e-06 5.205862001493216 -0.23176933459677307 LGPQNFIDETSDIENLLKEEEDYKEENNDSK ddPTM_A459_Selumetinib_30min_R1 1 LGPQNFIDETSDIENLLKEEEDYKEENNDSK 31 2 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 63.095 0.00048539 2113700.0 380.78 567.06 510.23 525.77 591.8 322.77 664.73 539.44 414.38 655.88 False True 389.65143313109866 500.66835158095796 440.9435684927723 433.9541394252366 538.2717944907764 319.5232268517116 614.5888809228068 525.1322988519316 703.1725948822506 740.0685868122127 0.5265071914611206 0.6765161506686124 0.5958144641594667 0.586370165087617 0.7273269046715519 0.4317481278701921 0.8304485447356982 0.709572475051127 0.9501451722347941 1.0 9.531515170338684 -8.05481674686962 1.1029864287655002 1.0044090246445398 0.6038681127600921 0.6864365037488311 0.09645198006668396 0.26683841124531854 0.6037332710864325 0.08312535977134837 0.029137349908460352 8.814207152463047e-09 8.05481674686962 -0.40054091188444774 LGQGVLVQVS(ph)PSLVK ddPTM_A459_Selumetinib_30min_R2 2 LGQGVLVQVSPSLVK 15 0 Q13868-3;Q13868 Q13868-3 EXOSC2 Exosome complex component RRP4 1 LGQGVLVQVS(0.757)PS(0.243)LVK;LGQGVLVQVS(0.996)PS(0.004)LVK 116.58 0.0022404 5238600.0 51797.0 50986.0 60374.0 66912.0 60526.0 43892.0 45154.0 48942.0 44622.0 46876.0 True False 48918.33009981967 54896.46225417057 56489.602570241 57798.470170361776 52922.182770694686 49937.72458809439 47253.75047095358 49084.41311721573 53547.64684285145 45522.56808152531 1.0745951329506054 1.2059175166888163 1.2409142311364132 1.2696662909450065 1.1625482700342735 1.0969883003670198 1.0380291021000383 1.0782434995607364 1.1762879182684556 1.0 15.474294326780381 -6.695396924424743 3.3596247217345807 1.0787957450096208 1.2026111788294365 0.4491697637929899 0.06331811664847867 0.23059448124860263 5.243814480684901 0.02291445984581908 0.022192553724375178 2.0165225158977636e-07 6.695396924424743 0.12381543381981563 LGQSDPAPLQHQMDIYQK ddPTM_A459_Selumetinib_30min_R2 1 LGQSDPAPLQHQMDIYQK 18 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 138.98 0.006608 5145200.0 46888.0 45804.0 51911.0 41681.0 52492.0 33851.0 40631.0 38051.0 28621.0 45807.0 False True 44282.15266753566 49317.01951692681 48571.102776423286 36003.975896264514 45897.485675565964 38513.66798121717 42520.4220087991 38161.72211031783 34345.9997375566 44484.43288912085 0.9954527863243894 1.1086354554603712 1.0918674156752457 0.8093612429769713 1.0317651073571557 0.8657785539767128 0.9558494791825912 0.8578668903217758 0.7720903135522784 1.0 15.441012939834197 -5.746720855900768 24.97724955657504 0.899558114100545 1.0696503055659805 0.4698261462439889 0.08094285605792945 199.9469597807931 339305.990101561 0.021439582312456507 0.03693279285367667 1.791757141351518e-06 5.746720855900768 0.17009219146543553 LGRGS(ph)VSDCSDGTSELEEPLGEDPR ddPTM_A459_Selumetinib_30min_R1 1 LGRGSVSDCSDGTSELEEPLGEDPR 25 1 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 LGRGS(0.74)VS(0.073)DCS(0.09)DGT(0.044)S(0.054)ELEEPLGEDPR 62.706 0.0022608 4172300.0 245.82 261.12 383.64 234.12 386.76 396.3 443.61 544.01 268.45 239.04 True False 251.54712771754478 230.5479490086055 331.5437951836763 193.23533697669387 351.7776262880237 392.31358181161 410.1481405475401 529.5810876064792 455.54004318775054 269.72311244677593 0.932612431451095 0.8547578548875718 1.2292005389382394 0.7164211298904714 1.3042175848294777 1.4545048744720557 1.5206266041753245 1.9634249464290185 1.6889173458490385 1.0 8.075335340505381 -6.628042184980671 2.072985476475724 1.607519082062795 0.9473058886185637 0.5221569105787499 0.26062522234542496 0.23197305083299957 2.0361490402302604 0.09615790313898358 0.09674338991441708 2.354820538453063e-07 6.628042184980671 -0.6602131934442312 LGRGS(ph)VSDCSDGTSELEEPLGEDPR ddPTM_A459_Selumetinib_30min_R2 2 LGRGSVSDCSDGTSELEEPLGEDPR 25 1 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 LGRGS(0.873)VS(0.072)DCS(0.017)DGT(0.026)S(0.013)ELEEPLGEDPR;LGRGS(0.805)VS(0.189)DCS(0.006)DGTSELEEPLGEDPR 75.956 0.00016185 4618000.0 7375.4 5878.1 8027.200000000001 7280.5 8733.9 6792.7 8689.4 8394.7 7538.799999999999 11725.900000000001 True False 6965.504794065485 6328.931368929511 7510.738691354536 6288.883340436974 7636.66939994333 7728.332767008769 9093.474317719445 8419.127187182597 9046.77065167156 11387.342799452968 0.6116883382486824 0.555786497376152 0.659569034113502 0.5522696076857442 0.6706278659065383 0.6786774494379871 0.7985598113509222 0.7393408045630312 0.7944584448714546 1.0 13.475143517527156 -8.313228144401148 0.29207057969542405 1.048556664436067 0.5406427732752208 0.8944321461421301 0.04150554167972414 0.5321265396657793 0.1563377826930611 0.10105787547996868 0.07062898046603738 4.861517524388572e-09 8.313228144401148 -0.5079138911608463 LGRGSVS(ph)DCSDGTSELEEPLGEDPR ddPTM_A459_Selumetinib_30min_R1 1 LGRGSVSDCSDGTSELEEPLGEDPR 25 1 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 LGRGS(0.422)VS(0.572)DCS(0.005)DGT(0.001)SELEEPLGEDPR 83.165 0.0029737 0.0 255.44 266.02 397.97 301.96 367.41 272.0 458.61 521.93 288.81 288.2 True False 261.39125500028314 234.87425473065713 343.9278598927321 249.22835449121158 334.17783037150406 269.26392695624 424.0166784709708 508.0867209324276 490.0894761521856 325.19327730572627 0.8038027635932323 0.722260486676184 1.0576106085040398 0.766400697321005 1.0276283481018307 0.8280119724095496 1.3038912796230318 1.562414589692629 1.5070713644902145 1.0 8.345153622778254 -7.335240589738661 4.272035930194956 1.4050971868672812 0.8715519956668568 0.639910592232543 0.17351495328394362 0.13069121912948356 4.566278152353443 0.07247110549979247 0.04807369801159855 4.621249432633308e-08 7.335240589738661 -0.5335451912004244 LGS(ph)ALLIR ddPTM_A459_Selumetinib_30min_R1 2 LGSALLIR 8 0 Q14993 Q14993 COL19A1 Collagen alpha-1(XIX) chain 1 LGS(1)ALLIR;LGS(1)ALLIR 104.01 0.014949 72614000.0 5872.6 7381.9 6540.299999999999 6786.0 7940.5 5286.8 7459.1 6036.0 3444.0 5401.799999999999 True False 6009.420153909582 6517.6237162477955 5652.163183296314 5600.95248899643 7222.283177009138 5233.6195920303335 6896.454081644138 5875.905672308797 5844.2164601922605 6095.173647987763 0.9859309186200969 1.06930894715354 0.9273178271405438 0.9189159837711115 1.1849183623166297 0.8586497931454571 1.1314614611383396 0.9640259673731603 0.9588269010386025 1.0 12.573451607644108 -4.437165796572008 14.954938653370585 1.0023764546945344 0.6716233716720441 0.0023095994860480307 0.0954432910451126 2030906.3147758034 6213353.744541266 0.022323370186391016 21596774.516565755 3.6545524852174454e-05 4.437165796572008 -0.3307530830224903 LGS(ph)ALLIR ddPTM_A459_Selumetinib_30min_R2 3 LGSALLIR 8 0 Q14993 Q14993 COL19A1 Collagen alpha-1(XIX) chain 1 LGS(1)ALLIR;LGS(1)ALLIR;LGS(1)ALLIR 120.31 0.0074507 37545000.0 79952.0 75583.0 78075.0 75658.0 79103.0 70798.0 67522.0 67326.0 55452.6 78042.0 True False 75508.58791321464 81379.97306234999 73051.73950163252 65353.249882670294 69165.37395020758 80549.78185974459 70661.9067923047 67521.90751358065 66544.66947509976 75788.7246825326 0.9963037144312507 1.0737741452074603 0.963886644189292 0.8623083467418813 0.9126077030578199 1.0628201252515506 0.932353817646314 0.8909228621595048 0.8780286217223633 1.0 16.209695609811668 -5.4549643026390475 6.085158850884691 0.9324618132313253 1.0328606336252657 0.3137493237911947 0.05882339594356128 0.2712966562205863 18.747501762245594 0.016251638515361783 0.03398310511540069 3.5078070561258453e-06 5.4549643026390475 0.10039882039394044 LGS(ph)DFGSSR ddPTM_A459_Selumetinib_30min_R2 3 LGSDFGSSR 9 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 LGS(1)DFGSSR;LGS(0.826)DFGS(0.161)S(0.013)R;LGS(0.896)DFGS(0.102)S(0.001)R 141.1 0.0022363 9962400.0 36544.8 27158.1 26578.0 29719.8 25565.9 25578.8 32044.8 29481.9 20967.5 26059.5 True False 34513.78631642546 29241.038942944913 24868.000415938408 25671.911970485395 22354.083079954125 29102.04751877218 33534.94669556659 29567.68744800872 25161.58588089926 25307.09452428767 1.3637988463393917 1.1554482840723483 0.9826493670410147 1.0144156195349727 0.88331290099306 1.1499560919900318 1.32512037932219 1.168355672739598 0.9942502825344584 1.0 14.6272542625012 LGS(ph)FGSITR ddPTM_A459_Selumetinib_30min_R1 2 LGSFGSITR 9 0 Q14315-2;Q14315 Q14315-2 FLNC Filamin-C 1 LGS(0.976)FGS(0.023)IT(0.001)R;LGS(0.874)FGS(0.122)IT(0.004)R 128.51 0.004305600000000001 35383000.0 3422.0 4100.799999999999 3808.2 4156.5 3042.5 3332.2 3515.0 3294.0 2559.8999999999996 3038.3 True False 3501.725941947108 3620.6764295897997 3291.06735694525 3430.6453021682373 2767.3064121970033 3298.6810933955253 3249.8607200572656 3206.6324195800507 4343.9633323014405 3428.2954005481915 1.0214189656431516 1.056115651239052 0.9599719313624496 1.00068544315629 0.807196022768197 0.962192783290512 0.9479523612631532 0.9353430918080465 1.267091316462062 1.0 11.743275709907348 -8.235816446824389 24.962175138349114 1.133545706584926 0.9602247545641877 0.3891770103553184 0.08627699662922078 637.7289798044404 621285.4287879636 0.05753140743474172 0.021727950966288642 5.8100992762575364e-09 8.235816446824389 -0.17332095202073827 LGS(ph)FGSITR ddPTM_A459_Selumetinib_30min_R2 3 LGSFGSITR 9 0 Q14315-2;Q14315 Q14315-2 FLNC Filamin-C 1 LGS(0.978)FGS(0.018)IT(0.004)R;LGS(0.95)FGS(0.05)ITR;LGS(0.678)FGS(0.321)ITR 120.63 0.0065183 13314000.0 34952.6 32669.0 34351.4 37760.0 31017.0 38380.0 29701.300000000003 27479.6 33119.5 31141.8 True False 33010.074418343844 35174.60725260853 32141.268322976408 32617.02286036678 27120.367164501804 43666.49662104855 31082.46930200943 27559.56108650731 39744.32543614849 30242.655317886423 1.0915071468218827 1.1630793289438843 1.0627793090630864 1.078510551323054 0.8967587957946932 1.4438711205104686 1.0277691880985833 0.9112811291476695 1.31418108027844 1.0 14.88429719390236 -10.808630208343883 4.872985049191022 0.9999654364596874 1.1045077168478827 0.040494784954708596 0.15859764514701985 5.742964019318977e-05 8.417977412687596e-06 0.14808119610031728 0.035903096397036684 1.5537093943215287e-11 10.808630208343883 0.10454228038819535 LGS(ph)LSAR ddPTM_A459_Selumetinib_30min_R1 4 LGSLSAR 7 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;H0Y4T4;Q00G26 H0Y2V6 CEP170;PLIN5 Centrosomal protein of 170 kDa;Perilipin-5 1 LGS(0.981)LS(0.019)AR;LGS(0.998)LS(0.002)AR;LGS(0.998)LS(0.002)AR;LGS(0.998)LS(0.002)AR 128.61 0.0049352 108340000.0 15728.2 18072.0 16058.0 16111.8 14397.199999999999 16211.099999999999 18218.9 18659.0 13915.5 14141.7 True False 16094.636458250301 15956.121838555131 13877.411800280152 13298.176585943515 13094.9758020321 16048.031052501125 16844.633704879463 18164.102707026155 23613.587152092157 15956.924946823015 1.0086302036191943 0.9999496702359283 0.8696795809046598 0.8333796536776436 0.8206453214307609 1.0057095026755922 1.0556315681758714 1.138320996530261 1.479833190341198 1.0 13.96189503666068 -7.556941177359464 1.7577099938678193 1.243675859460515 0.9115579951774546 0.5075045240738099 0.12651587631802783 0.283807221381454 1.7142721150921347 0.08174975094132493 0.03916588730926851 2.7736957600347117e-08 7.556941177359464 -0.33211786428306045 LGS(ph)LSAR ddPTM_A459_Selumetinib_30min_R2 6 LGSLSAR 7 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;H0Y4T4;Q00G26 H0Y2V6 CEP170;PLIN5 Centrosomal protein of 170 kDa;Perilipin-5 1 LGS(0.997)LS(0.003)AR;LGS(0.997)LS(0.003)AR;LGS(0.991)LS(0.009)AR;LGS(0.987)LS(0.013)AR;LGS(0.997)LS(0.003)AR;LGS(0.996)LS(0.004)AR 132.76 0.0034751 113071200.0 161993.0 146341.6 138604.7 158775.0 147300.0 152594.0 157815.0 170452.0 123967.8 238545.0 True False 152990.07756935904 157565.53015759107 129687.02450338726 137149.57109784795 128794.85712129223 173612.43838958538 165153.71020448997 170947.9871001525 148764.8239497383 231657.58603565657 0.6604147102949217 0.6801656395285872 0.5598220490971788 0.5920357431193208 0.5559708159156429 0.7494355844788225 0.7129216574805783 0.7379339050603778 0.6421754905399062 1.0 17.82163440117158 -12.536749709458487 0.2256649695395792 1.670080786954724 0.6019072469323157 0.7491326193182584 0.06138705046574772 29.556690568923656 0.6571060486621529 9.50211286003312 0.12511766828654758 2.90569676942675e-13 12.536749709458487 -1.0681735400224084 LGS(ph)LSER ddPTM_A459_Selumetinib_30min_R2 2 LGSLSER 7 0 O60664-3;O60664;O60664-4;O60664-2 O60664-3 PLIN3 Perilipin-3 1 LGS(0.925)LS(0.075)ER;LGS(0.999)LS(0.001)ER 98.582 0.021764 10552300.0 71239.0 68515.0 65560.0 72443.0 66368.0 37887.0 40532.0 49014.0 29566.0 51481.0 True False 67279.82157231218 73769.88018955216 61341.94097633084 62576.138428854545 58030.25850255196 43105.590346056946 42416.81831263431 49156.622625295495 35480.02614306272 49994.6097662984 1.3457415086709172 1.4755566756974825 1.2269710927453168 1.2516577031277762 1.1607303022029072 0.8622047566238755 0.8484278307384185 0.9832384502065301 0.7096770293620728 1.0 15.609484936784208 -6.407260756750937 1.1945832294150833 0.8645021407779245 1.376505515656952 0.8228570054724302 0.09764299575241434 0.17776078442094942 0.52715486562214 0.041276671245812094 0.05228653449118138 3.9150674015924973e-07 6.407260756750937 0.5120033748790274 LGS(ph)LVDEFK ddPTM_A459_Selumetinib_30min_R1 1 LGSLVDEFK 9 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 LGS(1)LVDEFK 97.734 0.020328 6465400.0 1017.1 1197.5 1684.4 1636.3 1030.4 1378.0 1583.7 1543.0 1196.1 1186.3 True False 1040.7964510679149 1057.296143297354 1455.6677317469102 1350.550922155152 937.2005019318951 1364.138571123893 1464.240233955815 1502.0746276296345 2029.694340312417 1338.573160540538 0.7775417001844143 0.789868028483703 1.087477154524066 1.008948156117053 0.7001488820778672 1.0190990013373875 1.09388136346954 1.1221460820438622 1.5163118461846288 1.0 10.38648027718173 -7.4386223691022115 1.663445114072484 1.2469173668940894 0.889374938963896 0.4486409689296593 0.16278811055565845 0.3529499302657364 1.897657638588878 0.10081120584136265 0.05285624864108878 3.642316077911327e-08 7.4386223691022115 -0.3575424279301934 LGS(ph)PAPQGCYAEALNGAAR ddPTM_A459_Selumetinib_30min_R1 2 LGSPAPQGCYAEALNGAAR 19 0 A0A2U3U043 A0A2U3U043 1 LGS(1)PAPQGCYAEALNGAAR;LGS(1)PAPQGCYAEALNGAAR 161.14 1.4993e-06 11329700.0 781.23 1242.21 970.99 992.14 710.29 1131.96 1078.58 928.51 657.1800000000001 999.56 True False 799.4311389910405 1096.7714757122387 839.1348912662858 818.8813737743765 646.044394911885 1120.573510137447 997.2218422302599 903.8828985744606 1115.1864614718788 1127.8632625389023 0.7088014704827452 0.9724330174948037 0.7440040997322069 0.7260466769092335 0.572803828593186 0.9935366700524978 0.8841690968685698 0.8014117744554906 0.9887603386970092 1.0 10.139376456641106 -6.789516080988891 24.999994754788304 0.9180759049631533 0.7563748558017903 0.42940441598715173 0.10764665491454906 257.08845535386297 228914.27287439306 0.03936225616435746 0.03472091637070302 1.623618230284728e-07 6.789516080988891 -0.16170104916136296 LGS(ph)PAPQGCYAEALNGAAR ddPTM_A459_Selumetinib_30min_R2 2 LGSPAPQGCYAEALNGAAR 19 0 A0A2U3U043 A0A2U3U043 1 LGS(1)PAPQGCYAEALNGAAR;LGS(1)PAPQGCYAEALNGAAR 213.64 6.1657e-17 13527300.0 18354.5 22007.0 19786.5 21578.0 17190.2 10522.9 17076.9 16988.4 14332.6 14694.7 True False 17334.430368885067 23694.866136341985 18513.458131912303 18639.039175873782 15030.613393662155 11972.333957624593 17871.00968723541 17037.833431418992 17199.5204863039 14270.425829584217 1.214710098765856 1.6604175950531084 1.2973304618234864 1.3061305526870075 1.0532701387580168 0.8389612265672256 1.25231089111488 1.193926070243652 1.2052562895949002 1.0 13.800740765033296 -5.956914026315163 2.2808662193122866 1.0981976255919148 1.4268462067794287 0.43922939865096633 0.15484420181910008 0.28118733792343964 2.955734727828814 0.04907954481176822 0.07842774508297573 1.104297206845521e-06 5.956914026315163 0.32864858118751394 LGS(ph)PLAVDEALR ddPTM_A459_Selumetinib_30min_R1 4 LGSPLAVDEALR 12 0 Q7RTP6 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 LGS(1)PLAVDEALR;LGS(1)PLAVDEALR;LGS(1)PLAVDEALR;LGS(1)PLAVDEALR 167.22 0.00043822 47846100.0 7728.9 9778.6 8960.099999999999 9179.49 6850.67 7591.75 7459.0 7561.09 5177.72 7930.929999999999 True False 7908.968332178549 8633.716966052194 7743.367634306271 7576.464391868242 6231.028108084021 7515.383887757486 6896.361624724648 7360.545331318315 8786.212674293458 8948.942119300156 0.8837880753660593 0.9647751489454696 0.8652830168167222 0.8466324053575119 0.6962865582341383 0.8398069612663022 0.7706342864651327 0.8225045187680731 0.981815789750641 1.0 13.12750143190555 -10.413270646024552 5.715624208923425 1.0000000692955975 0.8476618581988347 0.23587800211910748 0.07929173233718784 7.430239885581839e-08 1.4333422588396806e-08 0.08144970014784401 0.01975444495628561 3.861262737648577e-11 10.413270646024552 -0.15233821109676282 LGS(ph)PLAVDEALR ddPTM_A459_Selumetinib_30min_R2 3 LGSPLAVDEALR 12 0 Q7RTP6 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 LGS(1)PLAVDEALR;LGS(1)PLAVDEALR;LGS(1)PLAVDEALR 174.94 0.00012235 17652300.0 53770.0 47208.8 49953.6 52461.0 49337.4 41963.6 54689.0 50701.0 38377.3 51619.0 True False 50781.678658364464 50829.563159782825 46739.63976136733 45315.72129972724 43139.19473004777 47743.70499236668 57232.14686419765 50848.53151599759 46053.832351355 50128.62534773133 1.0130275527426305 1.0139827854282706 0.9323942046514273 0.9039889082411892 0.8605700721055204 0.9524239825285258 1.1417058909393734 1.0143611791321312 0.9187132508001091 1.0 15.613347051906233 -7.033038881495998 24.987357538062128 1.0237737240170448 0.9417624983830768 0.22206065291597987 0.06633308521459057 979.4729282525217 740773.8362984702 0.027207849358173768 0.02109109295064483 9.26746849916687e-08 7.033038881495998 -0.08201122563396801 LGS(ph)PLAVDEALRR ddPTM_A459_Selumetinib_30min_R1 3 LGSPLAVDEALRR 13 1 Q7RTP6 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 LGS(1)PLAVDEALRR;LGS(1)PLAVDEALRR;LGS(1)PLAVDEALRR 154.13 0.00020176 39178700.0 6495.7 6574.4 8481.2 8008.9 6140.700000000001 6938.8 6098.2 6325.3 4483.6 5614.1 True False 6647.037171568038 5804.66619164436 7329.499623896874 6610.295960672494 5585.274769228642 6869.00197192632 5638.207864311014 6157.532496529961 7608.341730812434 6334.724420964881 1.0493017106741933 0.9163249742062521 1.1570352768053758 1.0435017407853773 0.8816918303097887 1.084341088176344 0.8900478520661873 0.9720284715387933 1.2010533095382168 1.0 12.62906614394055 -8.229117980713598 24.715793073763468 1.100526820621851 0.9985253802724569 0.15384116374287327 0.09496236450365628 892.4620566852899 682457.2532332487 0.062247887327527646 0.02352202439800414 5.9004076754946685e-09 8.229117980713598 -0.10200144034939418 LGS(ph)PLAVDEALRR ddPTM_A459_Selumetinib_30min_R2 2 LGSPLAVDEALRR 13 1 Q7RTP6 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 LGS(1)PLAVDEALRR;LGS(1)PLAVDEALRR 115.04 0.0020956 18275400.0 67578.0 69516.0 74497.0 60747.0 67703.0 58119.0 59404.0 55822.0 42806.0 70795.0 True False 63822.28529616801 74847.6536708296 69703.94412620079 52473.15380557997 59197.54386750058 66124.36469824702 62166.403706792924 55984.432778170434 51368.3960995719 68750.96440249997 0.9283111277177555 1.088677872686073 1.013861328811646 0.7632351671225706 0.8610431050963991 0.961795449313618 0.904225915186324 0.8143075993874304 0.7471661895364483 1.0 16.069092330586045 -5.712751824327846 14.317666849201581 0.862369521015841 1.018186150917499 0.39127036520046343 0.08309991784429677 1.8397562251974646 539.3003354841883 0.02273883857859897 0.0393748711133324 1.9375288399933437e-06 5.712751824327846 0.155816629901658 LGS(ph)PVDNLEDMDRDDLTDDSVFTR ddPTM_A459_Selumetinib_30min_R1 2 LGSPVDNLEDMDRDDLTDDSVFTR 24 1 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 LGS(0.863)PVDNLEDMDRDDLT(0.114)DDS(0.023)VFTR;LGS(0.979)PVDNLEDMDRDDLT(0.02)DDS(0.001)VFTR 99.971 3.3315e-06 20351000.0 1003.0699999999999 995.3299999999999 1119.22 1188.06 894.28 747.3 1128.17 1167.7 683.89 1064.78 True False 1026.4395793655415 878.7963008836365 967.236071435393 980.5876236482616 813.3925318979578 739.7828404941113 1043.071228605122 1136.728802775842 1160.511380650663 1201.454884835501 0.8543305223700332 0.7314434457553171 0.805054008805186 0.816166829087819 0.6770063047430406 0.6157391757539026 0.8681734468522602 0.9461269142298914 0.9659217298113997 1.0 10.230566760307472 -7.547503852771191 4.004528896673853 0.9633338919868496 0.750186890250745 0.6884665449189148 0.06667777933319503 0.13609671776739893 4.912994229019629 0.03499070919788822 0.020089249736827464 2.834628486443438e-08 7.547503852771191 -0.21314700173610457 LGS(ph)PVDNLEDMDRDDLTDDSVFTR ddPTM_A459_Selumetinib_30min_R2 2 LGSPVDNLEDMDRDDLTDDSVFTR 24 1 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 LGS(0.995)PVDNLEDMDRDDLT(0.004)DDSVFTR;LGS(1)PVDNLEDMDRDDLTDDSVFTR 53.088 0.012268 12683900.0 2274.94 3918.2000000000003 4324.4 5632.4 5681.1 2621.3 3826.46 3437.73 2592.58 3115.3999999999996 True False 2148.50794210637 4218.713341001281 4046.1728120507214 4865.257403568054 4967.389428321606 2982.360281207778 4004.397971986649 3447.7332251531616 3111.168442737656 3025.4503072187003 0.7101448458697363 1.3944084062248403 1.3373787043854548 1.6081101685787362 1.6418677961655672 0.9857574834701103 1.323570895358019 1.1395768811429154 1.028332356117181 1.0 11.562934173377116 -7.898886728891972 1.1556016339566606 0.9949018672044155 1.3240960996022302 0.14555237668856003 0.2597865519499257 0.9246700442427805 2.227783033182182 0.23893061709215316 0.08754230756021698 1.2621566827830149e-08 7.898886728891972 0.32919423239781465 LGS(ph)QHSPGR ddPTM_A459_Selumetinib_30min_R2 1 LGSQHSPGR 9 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 LGS(0.5)QHS(0.5)PGR 93.839 0.015899 66437000.0 72105.0 54481.0 68913.0 101330.0 97461.0 80625.0 127210.0 203430.0 138730.0 217090.0 True False 68097.69275918478 58659.51751597433 64479.212606801244 87528.67919600014 85217.07786760527 91730.36190912042 133125.5170618331 204021.9476203505 166479.87644006932 210822.04763244098 0.3230102995579956 0.2782418545627857 0.30584662909269306 0.41517801472359556 0.40421331082116 0.43510801142131156 0.6314591787569183 0.9677448346202093 0.7896701427087915 1.0 17.685666225409555 -7.439827879679295 1.3388046384082237 0.9414899684078268 0.33381795338103465 0.9292112917788666 0.06930132564798054 0.1059061419820449 0.3628046625576446 0.04749013518507923 0.023698511079381222 3.632219789946915e-08 7.439827879679295 -0.6076720150267922 down LGS(ph)SSNLQFK ddPTM_A459_Selumetinib_30min_R1 1 LGSSSNLQFK 10 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1;Q8TDM6-5 Q8TDM6-4 DLG5 Disks large homolog 5 1 LGS(0.498)S(0.498)S(0.004)NLQFK 96.067 0.022094 58383000.0 1956.7 2431.0 2426.9 2586.1 2089.8 2142.1 2053.2 2405.1 1530.6 2108.9 True False 2002.2873029245782 2146.37738985876 2097.340310007466 2134.486182109296 1900.7779589841568 2120.5524188711843 1898.3254709591972 2341.3089351341773 2597.3164093990335 2379.597857425559 0.8414393619814459 0.9019916466813784 0.8813843496550035 0.8969944965484862 0.7987811692857094 0.8911389847885344 0.7977505379892041 0.983909498753371 1.091493842665088 1.0 11.21650206906999 -7.9372835411487355 5.257589355873127 1.0440125735511536 0.8620247063044797 0.7812858214457123 0.04118614595209921 0.08083458107448266 4.354811052405033 0.022803788965295974 0.010466701759671794 1.1553576887226112e-08 7.9372835411487355 -0.18198786724667393 LGS(ph)TGSQPNSEAESVPENVPKPPLLPPK ddPTM_A459_Selumetinib_30min_R2 1 LGSTGSQPNSEAESVPENVPKPPLLPPK 28 1 A0A0J9YVR0;Q8IZ21-3;Q8IZ21;Q8IZ21-2 A0A0J9YVR0;Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 LGS(0.674)T(0.217)GS(0.071)QPNS(0.03)EAES(0.009)VPENVPKPPLLPPK 45.072 0.029114 3267400.0 10087.0 8780.6 10147.0 10374.0 9973.5 8211.2 10636.0 15155.0 9496.0 15172.0 True False 9526.404921460335 9454.043785921047 9494.153067218263 8961.04330385182 8720.539765778733 9342.218266147833 11130.595074834175 15199.098540954694 11395.465340408697 14733.94493840989 0.6465617294812858 0.6416505440627324 0.6443727804675023 0.6081903618691621 0.5918672699152808 0.6340608917163538 0.7554388944279172 1.031570200953595 0.7734157680134858 1.0 13.846856135863371 -7.525576422584531 3.7378125939610665 0.9265210856106655 0.6287000603055624 0.8105764466311867 0.0662241090113655 0.08880050026744196 2.739213270020518 0.030375323909813862 0.017690412517700992 2.981422862260598e-08 7.525576422584531 -0.2978210253051031 LGS(ph)VDSFER ddPTM_A459_Selumetinib_30min_R1 3 LGSVDSFER 9 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 LGS(0.923)VDS(0.077)FER;LGS(0.569)VDS(0.431)FER;LGS(0.812)VDS(0.188)FER 155.26 0.00082084 128023000.0 5981.5 7255.4 6982.4 7138.4 5873.2 6105.6 7225.7 8564.9 6109.099999999999 6828.099999999999 True False 6120.85731202707 6405.9343950560515 6034.228431577787 5891.8124443637125 5341.970096997679 6044.183207441249 6680.659631555552 8337.731029283905 10366.696508989704 7704.553146326268 0.7944467635927276 0.8314478819723073 0.7832029083289619 0.7647182558761481 0.6933523587341168 0.7844949723428507 0.8671053991938604 1.0821822980427558 1.345528587070986 1.0 12.911495569465245 -7.756030519202903 2.6872301680030204 1.1841857991917963 0.7766007397284194 0.7905061080710278 0.08517618405381384 0.11029762636029883 1.6017553218156417 0.05101229877284291 0.022990622139389592 1.7537572556196165e-08 7.756030519202903 -0.407585059463377 LGS(ph)VDSFER ddPTM_A459_Selumetinib_30min_R2 3 LGSVDSFER 9 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 LGS(0.813)VDS(0.187)FER;LGS(0.998)VDS(0.002)FER;LGS(0.954)VDS(0.046)FER 141.1 0.0022363 70336800.0 70420.0 54372.0 60450.0 56389.0 51468.0 44945.0 54454.0 63051.0 49225.0 68979.0 True False 66506.33831359538 58542.157566464586 56560.712812983584 48708.72092354932 45002.129710242094 51135.76577991209 56986.218898554 63234.46797134508 59071.37546141726 66987.39704103449 0.9928186681571695 0.8739279349905684 0.8443485687066803 0.7271326111344766 0.6717999459312491 0.7633639764893065 0.8507006006465057 0.9439755948810717 0.8818281956116594 1.0 16.03160207307974 -7.623352835821592 3.8053014911817358 0.934739307840777 0.8061478747888369 0.30796269662811027 0.08623394265710368 0.32482282477110413 8.915780344630441 0.049321112185330356 0.026772685053965264 2.3803847768363376e-08 7.623352835821592 -0.1285914330519401 LGS(ph)VSLDLCDGDTGEPR ddPTM_A459_Selumetinib_30min_R1 1 LGSVSLDLCDGDTGEPR 17 0 Q8N6R0-2;Q8N6R0-3;Q8N6R0-4;Q8N6R0 Q8N6R0-2 METTL13 Methyltransferase-like protein 13 1 LGS(0.877)VS(0.123)LDLCDGDT(0.001)GEPR 151.11 0.00022801 7827200.0 610.79 525.77 627.84 727.71 570.73 470.03 619.38 540.03 296.75 505.18 True False 625.020218609548 464.21260397615845 542.5827764782592 600.6291093085166 519.1075722705658 465.3019249530936 572.6596679343012 525.7066501353413 503.56307623752986 570.0247738699057 1.0964790431234726 0.8143726821285554 0.9518582373089814 1.053689483056741 0.9106754584477752 0.8162836885038394 1.0046224202616794 0.922252284872308 0.8834055980038086 1.0 9.154880811442581 -4.73169632811822 24.50399660898721 0.9290894223966735 1.0964803266195342 0.3151414188553695 0.07425297602613179 3698.7233764728558 3047001.990352372 0.018518752112288792 2.1414213611251873 1.8548281221999795e-05 4.73169632811822 0.16739090422286074 LGS(ph)YSGPTSVSR ddPTM_A459_Selumetinib_30min_R2 4 LGSYSGPTSVSR 12 0 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 LGS(0.957)YS(0.043)GPTSVSR;LGS(0.955)YS(0.043)GPTS(0.001)VSR;LGS(0.964)YS(0.036)GPTSVSR;LGS(0.662)YS(0.338)GPTSVSR 190.35 0.00010344 167575000.0 167666.0 132690.4 153815.1 185267.0 147637.1 113696.5 125588.0 144181.4 73141.4 177966.0 True False 158347.7949401772 142867.32701311744 143918.80392721825 160033.31499659905 129089.6076055798 129357.16084093414 131428.0908479009 144600.9440034843 87771.72374146665 172827.65916880147 0.9162178999688833 0.8266461959863631 0.8327301580046986 0.9259705059147614 0.7469267837476029 0.7484748764350877 0.7604575070911221 0.8366770961252907 0.5078569261633038 1.0 17.398974597912826 -6.277777590010832 23.716088553269106 0.757339438970234 0.8688621879322359 0.16867415674956787 0.11670839986801189 711.3921990781924 1032634.1183872048 0.03410093642292477 0.03879884967105606 5.274999344344774e-07 6.277777590010832 0.11152274896200187 LGSFGS(ph)ITR ddPTM_A459_Selumetinib_30min_R2 1 LGSFGSITR 9 0 Q14315-2;Q14315 Q14315-2 FLNC Filamin-C 1 LGS(0.155)FGS(0.623)IT(0.222)R 92.239 0.026157 5154400.0 13890.0 11501.0 9755.1 11040.0 11386.0 8005.6 10019.0 11208.0 12185.0 9477.3 True False 13118.049406075546 12383.089718456364 9127.467486549805 9536.332954937743 9955.588887868515 9108.298732398813 10484.903352271864 11240.61342441571 14622.340477346255 9203.665724017397 1.4253070243352473 1.3454519198955814 0.9917208816842675 1.036145079677572 1.081698226163184 0.989638151310763 1.1392094918127043 1.2213191744983525 1.5887517990998492 1.0 13.167992870673018 -11.116782938605105 12.772896400168921 0.9999988025002597 1.1842031814845584 0.08633624257882877 0.18934816762189963 6.84705032614632e-06 2.177317498321711e-07 0.19440927425423005 0.047150867863226434 7.64217645903593e-12 11.116782938605105 0.18420437898429864 LGSPDTVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LGSPDTVSPR 10 0 H0Y9Y2 H0Y9Y2 BOD1L1 1 LGSPDT(0.055)VS(0.945)PR 94.82 0.024578 0.0 1780.6 2248.8 1898.0 2292.4 2527.4 1997.8 1909.1 1774.6 1077.6 1795.2 True False 1822.0845155555296 1985.5094505612433 1640.2620249677254 1892.0753736774875 2298.7971162487115 1977.703945857266 1765.0950499747728 1727.5318432868114 1828.6084952099827 2025.6314067287983 0.8995143487126429 0.9801928642919552 0.809753452439105 0.9340669617346666 1.134854598231694 0.976339495570455 0.8713801751451085 0.8528362255582376 0.9027350628232069 1.0 10.984155963212299 -10.59140813429703 6.083725251626737 1.0000001492118664 0.9307189213674235 0.058716546258688274 0.08496337989900729 1.860301433775565e-07 2.8560517327252627e-08 0.08901092692854629 0.021588274474267862 2.5620751589396933e-11 10.59140813429703 -0.0692812278444429 LGSPDTVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LGSPDTVSPR 10 0 H0Y9Y2 H0Y9Y2 BOD1L1 1 LGSPDT(0.001)VS(0.999)PR 98.754 0.019224 4881000.0 34502.0 23220.0 28771.0 32355.0 31570.0 29106.0 28317.0 28035.0 29385.0 35111.0 True False 32584.516962449125 25000.89933593225 26919.905183496292 27948.193184511834 27603.894360619088 33115.08730203853 29633.79660907102 28116.577208555897 35262.82108550018 34097.25420066632 0.9556346317708001 0.7332232439831969 0.7895036070960292 0.8196611087811779 0.80956355600269 0.9711951322283131 0.8690962748693097 0.8245994543456947 1.0341835995935147 1.0 15.057367945468151 -7.9126964610401656 0.5648978774236211 1.0103902335416468 0.814813018392389 0.38669918857619645 0.07581804667563809 0.8309641117429225 0.5968793684415631 0.07515890669272017 0.0423108659749141 1.2226539041087584e-08 7.9126964610401656 -0.19557721514925785 LGSQHS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 LGSQHSPGR 9 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 LGS(0.111)QHS(0.889)PGR 93.839 0.015899 9733600.0 3746.3 5377.5 4630.1 4059.8 5914.6 5184.7 4885.6 5481.3 3431.4 3401.7 True False 3833.5815009691546 4747.899800068075 4001.357851318789 3350.8321418844266 5379.625474307443 5132.546625330946 4517.075258580873 5335.918118228335 5822.835180459851 3838.3413303639463 0.9987599254508351 1.2369665413830941 1.0424705639556515 0.8729896206408264 1.401549526549624 1.3371782714395244 1.1768300080161371 1.3901624839921127 1.5170185971729975 1.0 11.906267295759587 -6.274637524004164 24.96850168583603 1.3186193755986337 1.0523569260671466 0.40868713252958344 0.15573978345270564 773.847880600393 1463977.1872481816 0.047808020617703444 0.05452502464528015 5.313277222445542e-07 6.274637524004164 -0.26626244953148714 LGSQHS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 4 LGSQHSPGR 9 0 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 LGS(0.001)QHS(0.999)PGR;LGS(0.001)QHS(0.999)PGR;LGS(0.001)QHS(0.999)PGR;LGS(0.018)QHS(0.982)PGR 111.5 0.006772800000000001 93282500.0 72573.5 51058.2 75646.3 101231.0 97288.0 81387.0 119913.0 228265.0 140853.0 204665.0 True False 68540.15540473898 54974.19976201099 70779.29941546403 87443.16316678481 85065.8116742449 92597.32049237312 125489.19210310178 228929.21335869504 169027.53576164538 198755.7896664688 0.34484608231919134 0.27659169000441675 0.3561118875291052 0.4399527848397412 0.4279916163297354 0.465884896474011 0.6313737693562771 1.1518115459321216 0.8504282368090496 1.0 17.60063736050146 -7.5005744243221395 2.514973654137917 1.0019997620118537 0.379786131265314 0.8998504086937552 0.09118666203047927 0.08241401551844584 1.037656685357096 0.04878132796546877 0.026989053398797938 3.158097804087173e-08 7.5005744243221395 -0.6222136307465397 down LGSQPIRAS(ph)NPDLR ddPTM_A459_Selumetinib_30min_R2 1 LGSQPIRASNPDLR 14 1 Q9UKE5-8;Q9UKE5-5;Q9UKE5-7;Q9UKE5-3;Q9UKE5-6;Q9UKE5-2;Q9UKE5-4;Q9UKE5 Q9UKE5-8 TNIK TRAF2 and NCK-interacting protein kinase 1 LGSQPIRAS(1)NPDLR 81.23899999999998 0.017775 5886700.0 25781.0 28934.0 29465.0 31550.0 35944.0 22752.0 22191.0 25717.0 20103.0 29004.0 True False 24348.195229520054 31153.14476252642 27569.253979066332 27252.83557321427 31428.39337656295 25885.881477907693 23222.9254706323 25791.832212321468 24124.161724751066 28166.579158557866 0.8644356523544084 1.1060322443544282 0.9787931230083349 0.9675592985502475 1.1158044148578847 0.9190282331478217 0.8244851225952466 0.9156891955935346 0.8564817754030102 1.0 14.78169673805587 -6.980632755956104 24.839477669933324 0.8892264739353863 1.0092546113118737 0.29827990251921277 0.07911536558297125 240.4468608605084 308384.2435912305 0.026221527959650878 0.023122007669040306 1.0456040193986623e-07 6.980632755956104 0.12002813737648732 LGSS(ph)GLGSASSIQAAVR ddPTM_A459_Selumetinib_30min_R1 1 LGSSGLGSASSIQAAVR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 LGS(0.036)S(0.568)GLGS(0.303)AS(0.028)S(0.066)IQAAVR 111.7 0.0019995 8170200.0 869.75 916.87 971.38 1242.2 926.63 908.02 978.11 769.7 668.39 782.6 True False 890.013482761104 809.5224341587009 839.4719314084027 1025.2730889819286 842.8164801098137 898.8861432161948 904.3303752191217 749.2850556620418 1134.2090127258732 883.0543331695404 1.0078807716922527 0.9167300399886924 0.9506458434956004 1.161053233612391 0.9544333213163665 1.0179284665189618 1.0240936953145514 0.8485152357190056 1.2844158848695812 1.0 9.786358397504301 LGSS(ph)SNLQFK ddPTM_A459_Selumetinib_30min_R1 1 LGSSSNLQFK 10 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1;Q8TDM6-5 Q8TDM6-4 DLG5 Disks large homolog 5 1 LGS(0.09)S(0.909)S(0.002)NLQFK 138.42 0.0016385000000000002 57890000.0 1654.2 2309.4 2271.2 2434.4 1813.6 2162.8 2374.6 2068.7 1295.2 1973.9 True False 1692.7396414871137 2039.0143743890667 1962.7835148085858 2009.2777393476154 1649.5602002170854 2141.04419566528 2195.4820101985724 2013.8313559153753 2197.85980233479 2227.2692924142016 0.7600067253889646 0.9154772533944111 0.8812511003916675 0.9021260905409876 0.7406200075739738 0.9612866315525502 0.9857281369954264 0.9041705746019267 0.9867957187846227 1.0 11.121060285240855 -6.8866326900896695 16.143381847979377 0.9629461572928346 0.8498534568992862 0.5419810814666625 0.05826192099728482 0.8405715244615201 115.62135894794622 0.020139219618087206 0.01776136004665613 1.2982768404148856e-07 6.8866326900896695 -0.11309270039354846 LGSSGLGS(ph)ASSIQAAVR ddPTM_A459_Selumetinib_30min_R1 1 LGSSGLGSASSIQAAVR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 LGS(0.002)S(0.018)GLGS(0.531)AS(0.17)S(0.28)IQAAVR 83.792 0.012883000000000002 9461800.0 623.28 628.51 1020.0 921.75 785.88 738.05 684.15 721.44 429.94 691.38 True False 637.8012113082389 554.9237570136283 881.4896024589461 760.7836658904306 714.7972927583832 730.6258870957829 632.5440146876748 702.3050676326146 729.576778424814 780.1253576114957 0.8175624661926005 0.7113263933794365 1.1299332778488276 0.9752069439451585 0.916259529041426 0.9365493378304418 0.8108235535687884 0.9002464293467618 0.935204542842389 1.0 9.607562157689522 -5.226166022487927 24.998113853965396 0.9411342258934073 0.7644443832829482 0.45604199819122526 0.08077247266674344 588.012813262375 416721.0949297103 0.021467286706105183 0.05679190945362822 5.940650154898716e-06 5.226166022487927 -0.17668984261045917 LGSSGLGSASS(ph)IQAAVR ddPTM_A459_Selumetinib_30min_R2 2 LGSSGLGSASSIQAAVR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 LGS(0.007)S(0.032)GLGS(0.351)AS(0.041)S(0.57)IQAAVR;LGS(0.002)S(0.033)GLGS(0.347)AS(0.037)S(0.581)IQAAVR 155.92 4.8856e-05 7116700.0 19186.0 18820.199999999997 23465.0 22078.6 23316.0 16014.7 19114.8 18956.3 19666.8 20826.3 True False 18119.718927643295 20263.64882351902 21955.287446760274 19071.456592290622 20386.83563231532 18220.57955802778 20003.676075257637 19011.459694615594 23600.709536304737 20224.99060577417 0.8959074088504236 1.0019114084401015 1.085552417536951 0.9429649172171078 1.0080022299983145 0.9008943397395629 0.9890573728892934 0.939998443766292 1.1669083064773742 1.0 14.303851412093149 -8.244511260343085 24.9732287138985 1.0834541728422824 0.9740416083580509 0.32534955373543983 0.06488417096114175 811.463175501315 1197117.038390729 0.042702621612366334 0.016050175317614296 5.6949345816813745e-09 8.244511260343085 -0.10941256448423153 LGSSS(ph)NLQFK ddPTM_A459_Selumetinib_30min_R2 1 LGSSSNLQFK 10 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1;Q8TDM6-5 Q8TDM6-4 DLG5 Disks large homolog 5 1 LGS(0.095)S(0.244)S(0.66)NLQFK 134.75 0.002048 29062000.0 115510.0 112810.0 106620.0 112940.0 104560.0 98167.0 108060.0 100100.0 70944.0 109890.0 True False 109090.4166231667 121462.16425867875 99760.1852790785 97557.37716763277 91424.23802173993 111688.61317869904 113085.0041168277 100391.27442755303 85134.78234098102 106717.19017149112 1.0222384645609754 1.1381686873829129 0.9348089573832207 0.9141674083703026 0.8566964504483683 1.0465850253292746 1.0596699925766757 0.9407226170987771 0.7977607188136433 1.0 16.703433060886212 -5.274625265750233 24.206278266250692 0.9453240994578834 1.08020357420148 0.31811476573829345 0.07985638345666855 554.8110360564169 1018508.0919704856 0.02199206291001107 0.04625233809745799 5.31342719538628e-06 5.274625265750233 0.13487947474359652 LGSTAPQVLSTSS(ph)PAQQAENEAK ddPTM_A459_Selumetinib_30min_R1 1 LGSTAPQVLSTSSPAQQAENEAK 23 0 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 1 LGSTAPQVLS(0.001)T(0.001)S(0.097)S(0.901)PAQQAENEAK 127.49 6.0667e-06 7973200.0 3465.7 4180.1 4314.8 4468.7 3515.5 3460.4 4053.9 3255.7 2122.6 3338.2 True False 3546.4440669217106 3690.691948724234 3728.873859499864 3688.3254328880594 3197.523645711936 3425.591517791812 3748.1110591863867 3169.3482599959825 3601.8971714297627 3766.6904868215665 0.9415278689155833 0.9798235245600277 0.989960250927436 0.9791952499926179 0.8488947145774356 0.9094433242595457 0.99506743978562 0.8414145709833363 0.9562498389585333 1.0 11.87908177494947 LGSVDS(ph)FER ddPTM_A459_Selumetinib_30min_R1 3 LGSVDSFER 9 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 LGS(0.03)VDS(0.97)FER;LGS(0.003)VDS(0.997)FER;LGS(0.16)VDS(0.84)FER 118.03 0.0073428 18040900.0 6404.7 6641.299999999999 6868.1 7946.9 5938.6 5712.7 5774.4 5192.6 2924.63 5309.4 True False 6553.917048623213 5863.733508543395 5935.449743772832 6559.123096788347 5401.4546785449875 5655.235424716592 5338.832359003888 5054.8753800581 4962.883503476216 5990.913207935541 1.0939762972933607 0.9787712332030308 0.9907420684897851 1.0948452880439257 0.9016079003431798 0.9439688455552466 0.8911550165560888 0.8437570708523086 0.8284018364516447 1.0 12.548560217582924 -6.285595865700576 20.166238751152257 0.8952773944949941 1.0317511630807574 0.5795416333569152 0.057326164359239505 50.28552301646316 41978.599966148366 0.01797332083584303 0.0204088908873366 5.180887170335502e-07 6.285595865700576 0.13647376858576332 LGSVDS(ph)FER ddPTM_A459_Selumetinib_30min_R2 1 LGSVDSFER 9 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 LGSVDS(1)FER 86.344 0.03397 3165800.0 18471.0 20374.0 18063.0 21040.0 17566.0 14763.0 13236.0 13353.0 14401.0 13292.0 True False 17444.455765271516 21936.620287264574 16900.84624550739 18174.31570397554 15359.202037967534 16796.469244829077 13851.500226636432 13391.855019291845 17281.602397559574 12908.225423236501 1.3514216860413055 1.69942959376707 1.3093082659591337 1.40796392285336 1.1898771158984374 1.3012221815241332 1.0730754826842357 1.0374667764311543 1.3388054384648738 1.0 13.656003057261165 -6.169744920687799 0.813785886471544 1.118653627565369 1.527271735737001 0.5362755864471093 0.13439359154377845 0.5137123690237136 0.7173672505330233 0.06744773040740551 0.12890569596267057 6.764801838355873e-07 6.169744920687799 0.408618108171632 LGT(ph)SESLPCTAEELSR ddPTM_A459_Selumetinib_30min_R1 1 LGTSESLPCTAEELSR 16 0 Q9BZL6-2;Q9BZL6;Q9BZL6-3 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 LGT(0.677)S(0.042)ES(0.277)LPCT(0.004)AEELSR 192.78 2.637e-06 12625000.0 3466.7 3218.3 3540.7 3948.1 3576.4 2787.5 3341.0 4108.8 1453.6 2874.6 True False 3547.4673649760484 2841.499939852922 3059.89238767293 3258.638450015742 3252.9152514647035 2759.4602808474983 3088.985680145467 3999.8212767366463 2466.6530332565235 3243.5829109751603 1.0936878946342479 0.8760373999499971 0.9433680197658321 1.0046416384146182 1.0028771703223511 0.850744487372418 0.9523375122286563 1.233149078200726 0.7604717070466195 1.0 11.663372601457052 LGTHGS(ph)PTASSQSSATNMAIHR ddPTM_A459_Selumetinib_30min_R2 1 LGTHGSPTASSQSSATNMAIHR 22 0 C9JD37;Q14449-2;Q14449 C9JD37 GRB14 Growth factor receptor-bound protein 14 1 LGT(0.275)HGS(0.669)PT(0.056)ASSQSSATNMAIHR 102.67 6.5035e-05 3384200.0 4040.9 4217.4 4869.3 5441.0 6245.2 5085.1 3619.9 3973.9 3991.4 4315.0 True False 3816.3229550043693 4540.861018921647 4556.014539292985 4699.926413751474 5460.622143203621 5785.526367058209 3788.2325226957705 3985.46339108544 4789.791529034044 4190.41473828359 0.9107267880046522 1.0836304524791742 1.0872466865079675 1.121589796545194 1.3031221213774924 1.3806572209193744 0.9040232910805972 0.951090438536855 1.143035195364925 1.0 12.03287732363545 -7.317870031571565 24.999965748569924 0.9954614773737387 1.1480247035145195 0.23132516813859494 0.13234475073211077 482.66490782939434 213828.66950025657 0.06008567685701412 0.040509768866562164 4.809832675853788e-08 7.317870031571565 0.15256322614078077 LGTSES(ph)LPCTAEELSR ddPTM_A459_Selumetinib_30min_R1 1 LGTSESLPCTAEELSR 16 0 Q9BZL6-2;Q9BZL6;Q9BZL6-3 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 LGTS(0.009)ES(0.989)LPCT(0.003)AEELSR 191.63 1.0707e-06 12447000.0 1815.4 1810.7 1763.8 2226.0 1886.8 1594.8 1803.8 2084.9 688.86 1613.7 True False 1857.6952878465156 1598.702402228407 1524.2856478598899 1837.2708871951174 1716.139273141595 1578.757759962543 1667.7379137522887 2029.6016792903608 1168.9451076562257 1820.834113769085 1.0202441143861969 0.8780055196346962 0.8371359237688344 1.009027057051347 0.942501714002505 0.8670519450531112 0.9159197431226227 1.1146549067499245 0.6419833079887415 1.0 10.830383776914193 -8.260137238535698 24.99999524959715 0.8209916825607915 0.9401088172004481 0.16725926009591363 0.11230053768207511 205.09562299336244 3937876.897132706 0.08137634792381641 0.026827222638141066 5.493672445046623e-09 8.260137238535698 0.11911713463965667 LGVIEDHSNR ddPTM_A459_Selumetinib_30min_R1 4 LGVIEDHSNR 10 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 ;;; 185.33 9.9262e-05 76262000.0 38112.6 43592.4 44207.7 47114.2 45619.6 37800.5 39999.600000000006 36741.3 21198.3 31586.899999999998 False True 39000.54942578999 38488.58154244304 38204.537155514045 38886.589413067435 41493.315234794565 37420.26129010792 36982.39796813728 35766.80137143792 35971.96683742558 35641.386297460944 1.0942489470048575 1.079884525849235 1.0719150157814064 1.091051540153972 1.1641891504582274 1.0499103760387036 1.0376251265729208 1.0035188045978423 1.0092751874802408 1.0 15.12126583216618 -7.197761856161731 2.4479858023428065 1.0089835699114624 1.096972664156834 0.7115927518285188 0.026031127554958216 0.1745914899404285 2.050816010372715 0.012388268990707038 0.00861035735906617 6.342173867787246e-08 7.197761856161731 0.0879890942453716 LGVIEDHSNR ddPTM_A459_Selumetinib_30min_R2 6 LGVIEDHSNR 10 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 ;;;;; 197.79 0.00016585 66704400.0 595179.0 506142.0 639040.0 687432.0 735312.0 526451.0 533550.0 577886.0 489532.0 578025.0 False True 562101.3338703116 544961.4638969594 597924.8621341436 593802.5757136565 642935.5327873155 598964.8466036376 558361.1322092685 579567.5525858226 587452.0786669076 561335.9163606898 1.0013635641107455 0.9708294944497924 1.0651819074943056 1.057838200632979 1.1453668187770003 1.0670346028932327 0.9947005276792055 1.032479012466072 1.0465250156724992 1.0 19.09850484568699 -5.2637566950733765 24.940130596299174 1.0544570517862457 0.9860965265010675 0.2933063038119724 0.040122020210113796 238.6992845290572 2569026.3091605636 0.011241121517818559 0.025353075634567047 5.448077851896043e-06 5.2637566950733765 -0.06836052528517822 LGVSVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 4 LGVSVSPSR 9 0 E7ERS3;Q86VM9;H3BP01 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 LGVSVS(1)PSR;LGVS(0.003)VS(0.997)PSR;LGVS(0.001)VS(0.999)PSR;LGVS(0.002)VS(0.989)PS(0.009)R 181.87 0.00066331 885580000.0 13100.0 14284.499999999998 15239.6 15895.1 15043.4 12633.3 14641.199999999999 12936.8 7167.7 10755.8 True False 13405.204511837266 12612.064099316116 13170.146025130738 13119.31917298072 13682.727126127988 12506.220472118632 13536.802496302256 12593.674039351305 12163.063391904785 12136.411700364084 1.1045443120090528 1.0391921772839794 1.0851762737033421 1.0809883099620912 1.1274112533375507 1.0304710140760514 1.1153875486850995 1.03767689744519 1.0021960108307715 1.0 13.56705431124894 -7.988561799161828 4.664349435038997 1.0053596615456895 1.0812986170161376 0.5720303664062754 0.02878605769344962 0.13464278831763773 7.62521415307419 0.017314844116944113 0.007254105909755475 1.0266873258957501e-08 7.988561799161828 0.07593895547044816 LGVSVS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 5 LGVSVSPSR 9 0 E7ERS3;Q86VM9;H3BP01 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 LGVS(0.006)VS(0.852)PS(0.142)R;LGVS(0.012)VS(0.942)PS(0.046)R;LGVS(0.001)VS(0.999)PSR;LGVS(0.001)VS(0.993)PS(0.006)R;LGVS(0.012)VS(0.988)PSR 181.87 0.00092557 1554757000.0 766377.0 677000.0 918113.0 896013.0 958158.0 670908.0 686928.0 769582.0 618853.0 773522.0 True False 723784.8343902059 728923.7231018993 859042.6091458523 773974.4836913631 837785.6259987989 763319.4871035551 718871.5131220098 771821.3562088406 742640.8921975523 751188.4100084829 0.9635197039076155 0.9703607156208225 1.1435780926600712 1.0303333669413548 1.1152802876569117 1.0161491803300522 0.956978972976822 1.0274670720759986 0.9886213396039563 1.0 19.518815278439845 -6.993864343906343 24.887658825736455 0.9942712340735995 1.0472459073200455 0.16465811102065853 0.05447332114691379 283.4343175261742 1149668.8045369212 0.019992835328793115 0.017585035255636653 1.0142281402600684e-07 6.993864343906343 0.052974673246446 LGYLVS(ph)PPQQIR ddPTM_A459_Selumetinib_30min_R1 2 LGYLVSPPQQIR 12 0 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 LGYLVS(1)PPQQIR;LGYLVS(1)PPQQIR 107.09 0.0086265 76510000.0 4969.6 6183.9 6406.9 7051.0 6177.5 5553.3 6594.1 5396.3 3078.7 4685.6 True False 5085.382010841718 5459.8861131828835 5536.878170582568 5819.675213662516 5618.746215726205 5497.438843992974 6096.701728059635 5253.172594347248 5224.329040648642 5287.042401608989 0.9618576180312265 1.0326919473014426 1.047254353189516 1.1007430566267886 1.0627390115154496 1.0397947333125144 1.1531403126640793 0.9935938082790043 0.9881382905230225 1.0 12.368245181713023 -1.5357742228682025 18.678500331791653 1.0436060171449424 0.005222362610000086 0.0 0.05471526572288071 0.0 0.0 0.01275464907892843 0.0 0.029122307090563446 1.5357742228682025 -1.0383836545349423 LGYLVS(ph)PPQQIR ddPTM_A459_Selumetinib_30min_R2 1 LGYLVSPPQQIR 12 0 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 LGYLVS(1)PPQQIR 101.38 0.012584 19818000.0 52424.0 52721.0 62001.0 63137.0 59096.0 45771.0 50579.0 44176.0 41654.0 53016.0 True False 49510.483949899535 56764.531175266304 58011.923161584644 54537.63168260002 51671.83215505686 52075.53978223064 52931.02372038716 44304.544846269484 49985.96391000253 51485.29032788943 0.9616432894635898 1.1025388186364586 1.1267669424049018 1.059285697628807 1.00362320627852 1.0114644289773282 1.028080513546499 0.860528212312903 0.9708785478660354 1.0 15.651872683645564 -7.015129673179757 1.1290902037630337 0.9451749988934586 1.066211440196892 0.353645619962799 0.057552576831271435 0.4934317916329224 1.28851168372656 0.03520192044215128 0.02492842112575188 9.657624751660162e-08 7.015129673179757 0.1210364413034335 LHAEFAAER ddPTM_A459_Selumetinib_30min_R2 1 LHAEFAAER 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 117.53 0.010543 3163500.0 14724.0 11523.0 12427.0 13446.0 18015.0 9731.1 9788.3 11337.0 10996.0 11506.0 False True 13905.699024842068 12406.777047715215 11627.460349494564 11614.63160435624 15751.794643856598 11071.470694869355 10243.475345148496 11369.988793058623 13195.507253910506 11173.791883821781 1.2444923951891156 1.1103461722496049 1.0406011200485699 1.0394530097855803 1.409708969670643 0.9908427515013436 0.9167411968697695 1.0175586686486358 1.1809336876066137 1.0 13.447831234453371 LHDFGYR ddPTM_A459_Selumetinib_30min_R1 2 LHDFGYR 7 0 A0A0C4DFS8;P43490 A0A0C4DFS8 NAMPT Nicotinamide phosphoribosyltransferase 0 ; 173.85 1.0885e-05 70384000.0 4471.0 5041.299999999999 5699.1 5634.3 7822.6 8962.599999999999 7910.0 9138.5 5844.0 7430.7 False True 4575.165600948426 4451.062252363211 4925.193522915467 4650.3752739099045 7115.047211192207 8872.444381389696 7313.342331622461 8896.117293968518 9916.841171127631 8384.502726147331 0.5456692841998405 0.5308677685180345 0.587416294535405 0.5546393657202311 0.8485950143475668 1.0581956582494396 0.8722452088679721 1.061019071080471 1.182758416930518 1.0 13.033509506639515 -6.4289714090630685 2.3735834756182115 1.0307676907624828 0.5486524473461617 0.9029343447838452 0.07409234021031079 0.09050601808620864 1.0036705715225436 0.026844417988612018 0.030603447020278125 3.7241622274902547e-07 6.4289714090630685 -0.48211524341632106 LHDFGYR ddPTM_A459_Selumetinib_30min_R2 4 LHDFGYR 7 0 A0A0C4DFS8;P43490 A0A0C4DFS8 NAMPT Nicotinamide phosphoribosyltransferase 0 ;;; 170.17 3.5052e-05 35339800.0 49600.0 42734.4 46601.399999999994 47338.9 54004.799999999996 42331.8 38284.200000000004 43294.0 41612.399999999994 45456.0 False True 46843.43056453182 46011.99106724646 43603.11665976793 40891.26015584258 47220.23421496237 48162.621200179885 40064.49115870313 43419.978372292484 49936.04274760139 44143.56717112836 1.0611609701349483 1.0423260741225309 0.9877569814585827 0.9263243271057416 1.0696968378633043 1.0910450669623308 0.907595233601939 0.9836082843955318 1.1312190189346896 1.0 15.429915595758674 LHDFLAHSSEESEETS(ph)SPPR ddPTM_A459_Selumetinib_30min_R1 1 LHDFLAHSSEESEETSSPPR 20 0 P46100-4;P46100;P46100-6;A0A096LNL9;A0A096LNW1;A0A087WWG0 P46100-4 ATRX Transcriptional regulator ATRX 1 LHDFLAHSSEESEET(0.041)S(0.48)S(0.48)PPR 87.79299999999998 0.0010811 5185400.0 1401.8 1489.4 1173.7 1679.8 2589.0 1692.5 1951.8 1409.6 397.51 868.36 True False 1434.4592125720212 1315.0203555967248 1014.3179866726123 1386.4544637512824 2354.825407125076 1675.4749866670445 1804.5741545968053 1372.2128289739035 674.5454370183005 979.8224645426808 1.4639991064519389 1.3421006388238845 1.0352058902283199 1.415005793318274 2.4033184503727005 1.70997813103729 1.8417358449105028 1.400470879808176 0.6884363866194226 1.0 9.936376558669208 -8.121794266682492 4.49712858903056 0.8557738524624081 1.5991255555535222 0.42325542383470094 0.34767960155420014 0.24449169162703507 7.625559804088617 0.2829027249443232 0.1000788257056874 7.554500135384487e-09 8.121794266682492 0.7433517030911141 LHDFLAHSSEESEETSS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 LHDFLAHSSEESEETSSPPR 20 0 P46100-4;P46100;P46100-6;A0A096LNL9;A0A096LNW1;A0A087WWG0 P46100-4 ATRX Transcriptional regulator ATRX 1 LHDFLAHSSEESEET(0.031)S(0.25)S(0.718)PPR 80.314 0.0021619 4128400.0 1166.4 1335.8 1165.4 1209.6 1256.2 1137.2 1568.5 1071.3 792.67 899.4 True False 1193.5748505806857 1179.403915003427 1007.1450810839764 998.3660670041386 1142.576931800124 1125.7608004949864 1450.1867821934045 1042.8856439271729 1345.1030956738093 1014.8467508978846 1.176113388080192 1.1621497669081078 0.9924110021467831 0.9837604210890317 1.1258615458828933 1.1092914270050829 1.4289712027065695 1.027628696652456 1.3254248431930542 1.0 9.987046171272523 -7.024197485479493 24.95561301667039 1.2079975357865789 1.0847180869362942 0.12882927506814745 0.13159370257176897 1356.3740055244818 1398866.0912005836 0.04824677701777224 0.03758707177674056 9.458069794805649e-08 7.024197485479493 -0.12327944885028463 LHDINAQMVEDQGFLDSLR ddPTM_A459_Selumetinib_30min_R1 1 LHDINAQMVEDQGFLDSLR 19 0 A0A087X253;P63010;P63010-2;A0A087WYD1;A0A087WU93;A0A087WZQ6;P63010-3 A0A087X253 AP2B1 AP-2 complex subunit beta 0 142.72 0.0017154 8204100.0 2760.2 2577.2 2636.1 2603.5 2237.5 2471.8 2142.0 2126.3 1149.3 1778.7 False True 2824.50728958574 2275.4602258922237 2278.1320990608106 2148.847598747747 2035.1185200627106 2446.935936214832 1980.4272154659075 2069.90361680421 1950.2781584491772 2007.0134710051886 1.407318550867085 1.1337543363635654 1.1350856045424724 1.0706692455190758 1.014003418244844 1.2191925821949334 0.9867533248165167 1.0313351886808828 0.9717314739658443 1.0 10.970834584714465 -1.522878745685067 0.7539611040428261 1.0414549373920987 64.93475348507651 0.716160164974837 0.0680564081384952 211.86856483441935 0.8992390400215045 0.025365497153435286 23003.255343476583 0.029999999972042283 1.522878745685067 63.89329854768442 LHFFMPGFAPLT(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 LHFFMPGFAPLTSR 14 0 P04350;K7ESM5;Q9BUF5;P68371;A6NNZ2;P07437;Q5JP53;Q5ST81;Q9BVA1;Q13885;Q3ZCM7;A0A075B736;Q5SQY0 P04350;P68371;P07437;Q9BVA1;Q3ZCM7 TUBB4A;TUBB6;TUBB4B;TUBB;TUBB2B;TUBB2A;TUBB8 Tubulin beta-4A chain;Tubulin beta-6 chain;Tubulin beta-4B chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-2B chain;Tubulin beta-2A chain;Tubulin beta-8 chain 1 LHFFMPGFAPLT(0.632)S(0.368)R 89.50200000000002 0.031284 4098100.0 1040.7 1108.4 1335.6 1455.1 1511.1 1071.5 1213.6 1136.6 485.71 896.3 True False 1064.9462851503083 978.6280127188197 1154.2328559256543 1200.9941006098895 1374.4212718063736 1060.7216828441594 1122.0571749250346 1106.4536758028796 824.2143951451748 1011.3488357013275 1.0529960064786283 0.9676463532389225 1.1412806493471097 1.1875171634296202 1.3589982242410659 1.04881881048352 1.1094660272653951 1.0940376225732251 0.8149654857451999 1.0 9.982064983914158 -8.142339026851024 5.755718996458599 0.9100186078976992 1.1252664719496963 0.3932599273793034 0.10598379482514522 0.2384162368270278 10.035101752816418 0.07930109295376422 0.02903096617713222 7.205447748204308e-09 8.142339026851024 0.21524786405199714 LHGELQDR ddPTM_A459_Selumetinib_30min_R1 2 LHGELQDR 8 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 0 ; 154.49 0.00099851 28640000.0 2993.7 4853.0 4458.799999999999 5117.2 4372.4 4082.5 3899.4 3476.4 1805.05 2738.0 False True 3063.4473852738333 4284.808503901508 3853.3194504352396 4223.577081740721 3976.917192009919 4041.433756613419 3605.265118575048 3384.1945790613518 3063.0380143641232 3089.448970378484 0.9915837466959472 1.3869167430775147 1.2472513666290383 1.3670972144988356 1.2872577699584766 1.3081406410536405 1.1669605658297608 1.0954039414500376 0.9914512405715104 1.0 11.593133828748769 -7.755723758566722 1.7288287784961807 0.998844061002976 1.2749719074416745 0.5192286950008855 0.10304703138552836 0.28496814501285667 1.631185908800997 0.07463651055987287 0.02982110587123802 1.7549964464428324e-08 7.755723758566722 0.2761278464386986 LHGELQDR ddPTM_A459_Selumetinib_30min_R2 1 LHGELQDR 8 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 0 95.815 0.030323000000000006 4508100.0 20084.0 17691.0 14618.0 17881.0 19794.0 15368.0 20477.0 24030.0 16148.0 16853.0 False True 18967.81168262212 19047.842814469295 13677.493794875003 15445.57695355451 17307.300759394817 17484.802503185878 21429.22107440574 24099.923321619342 19378.051212817994 16366.410100647354 1.1589475985250957 1.163837561037034 0.8357051858509892 0.9437364002594301 1.0574891288291894 1.0683346192390895 1.3093415686533563 1.4725234900881592 1.18401354320527 1.0 13.998450287313782 -7.184801842691669 4.459716966878414 1.2807932908754225 1.0274437984952325 0.3114777823609267 0.14384650741964503 0.23487603298356702 8.739245660752266 0.058221557695035876 0.04402737044142941 6.534286271758696e-08 7.184801842691669 -0.25334949238019 LHHCPGNHS(ph)WDSTISGSQR ddPTM_A459_Selumetinib_30min_R2 1 LHHCPGNHSWDSTISGSQR 19 0 O43353-2;O43353 O43353-2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1 LHHCPGNHS(1)WDSTISGSQR 77.506 0.0042023 2446100.0 14662.0 13151.0 14460.0 12278.0 14953.0 12085.0 11072.0 14695.0 9484.1 13339.0 True False 13847.144736636397 14159.639412870145 13529.65934285761 10605.715219268624 13074.470458483916 13749.59905329265 11586.86993875179 14737.760017111781 11381.185007894917 12953.868411115829 1.0689582676904483 1.0930819245253127 1.0444493423483976 0.8187295781210627 1.0093101183013868 1.061428031914698 0.8944717956845226 1.1377111106412954 0.8785935325797058 1.0 13.661095373533312 -5.535381067079751 24.991592914158375 0.9756474047448384 1.0779565372553657 0.21308707033691554 0.08734476061141094 328.13360302366425 655921.9518759997 0.022934044258006808 0.039753200942898026 2.9148682713937107e-06 5.535381067079751 0.10230913251052731 LHNGDLCS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 LHNGDLCSPK 10 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 LHNGDLCS(1)PK 101.53 0.016257 7561100.0 55300.0 44258.0 39450.0 40238.0 42537.0 36531.0 52858.0 49473.0 32734.0 39422.0 True False 52226.64738343969 47652.446288100306 36911.82994991235 34757.51498557834 37193.12177439511 41562.813654599406 55316.001736139966 49616.95823930395 39281.71466437854 38283.78442934314 1.364197614262237 1.244716189854429 0.9641635616781074 0.9078913044693135 0.9715111065636428 1.0856506030982405 1.4448937731908824 1.2960306557696095 1.026066655893886 1.0 15.224445829738645 -7.047235020741671 24.99675116633656 1.223396343825259 1.0765683264828938 0.061411721036309874 0.17501710950050753 912.2739907194725 482772.24487156136 0.07130284374340116 0.05523236913812728 8.969432775733019e-08 7.047235020741671 -0.14682801734236528 LHPDGS(ph)PDVAGEK ddPTM_A459_Selumetinib_30min_R1 2 LHPDGSPDVAGEK 13 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 LHPDGS(1)PDVAGEK;LHPDGS(1)PDVAGEK 167.37 0.00030769 33419000.0 12263.3 15273.599999999999 17011.0 18290.9 14394.5 13914.5 14511.9 13451.7 7280.700000000001 11045.4 True False 12549.01102977206 13485.359811495999 14700.999634734435 15096.737677716605 13092.520016555392 13774.532763355164 13417.255699402282 13094.917218720391 12354.816138711325 12463.184681306971 1.0068863898481595 1.0820155647474394 1.1795540233616109 1.2113065852550187 1.050495547594054 1.1052177365240388 1.0765511418222249 1.050687890259777 0.9913049075844809 1.0 13.605385142683893 -7.842640509750997 1.178923864617201 0.9918540183091221 1.113006126956423 0.37682421011998435 0.0552223910987515 0.5484975290912164 1.3750983788114546 0.0522451162936785 0.01957954965347259 1.436678161541482e-08 7.842640509750997 0.12115210864730097 LHPDGS(ph)PDVAGEK ddPTM_A459_Selumetinib_30min_R2 4 LHPDGSPDVAGEK 13 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 LHPDGS(1)PDVAGEK;LHPDGS(1)PDVAGEK;LHPDGS(1)PDVAGEK;LHPDGS(1)PDVAGEK 134.88 0.0011768 30696800.0 330196.0 299363.0 328027.0 347125.0 357202.0 291095.0 292416.0 318354.0 248826.0 331828.0 True False 311845.0281993175 322323.17949623964 306922.099948793 299845.97617597424 312327.09133360354 331190.69395268697 306013.92341131193 319280.35743365856 298598.15277933126 322247.2634473164 0.9677197095897153 1.0002355832229919 0.952442843627037 0.9304841660043933 0.9692156513368353 1.0277533171568196 0.949624583736276 0.9907930761555004 0.9266119115644514 1.0 18.297808581579986 -6.53022202563569 24.99928214200199 0.9789852876773304 0.9628140664894643 0.0607713677355014 0.030235085813269436 595.7635278701154 2028181.2712630746 0.010060523639435508 0.010083990409305722 2.949700856955826e-07 6.53022202563569 -0.01617122118786607 LHPFHVIR ddPTM_A459_Selumetinib_30min_R1 1 LHPFHVIR 8 0 X1WI28;P27635;F8W7C6;A0A087WV22;H7C123;H7C2C5;B8A6G2;A6QRI9;H7C2U2;Q96L21 X1WI28 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 102.77 0.02345 0.0 2460.6 2494.9 3089.1 3230.3 2563.7 2610.3 2104.2 2725.9 1606.0 2251.4 False True 2517.9271925058592 2202.7959481524563 2669.617187211694 2666.1887452409633 2331.8137876579963 2584.042751962769 1945.4784998988605 2653.6002770289206 2725.26470240092 2540.3891204931037 0.9911580758215165 0.8671096606353287 1.0508693985799726 1.049519825027215 0.9178963052736496 1.0171838365695693 0.7658190960608555 1.044564494321973 1.0727745133280728 1.0 11.310833781348132 LHPPS(ph)PVPQGVCPAHR ddPTM_A459_Selumetinib_30min_R1 2 LHPPSPVPQGVCPAHR 16 0 Q96F44-2;Q96F44-3;Q96F44 Q96F44-2 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 LHPPS(1)PVPQGVCPAHR;LHPPS(1)PVPQGVCPAHR 73.918 0.022115 9608800.0 3139.7 4710.0 3003.6000000000004 3331.2 3494.8 3775.1 4072.2 3352.0 2427.23 3566.1 True False 3212.8489012072873 4158.551010380405 2595.727617593814 2749.4684543685407 3178.6959570570543 3737.125921516553 3765.0306754529693 3263.0940711694993 4118.832032134861 4023.8436717555524 0.7984527141944264 1.0334772793412428 0.6450865961354136 0.6832940538092481 0.7899650722937328 0.9287453058249879 0.9356801562348802 0.8109395735410995 1.0236063744339914 1.0 11.974358541504332 -6.7610653109603 23.23371988491768 0.9277208418288163 0.7895936378916504 0.31580694448339475 0.10948073613924336 5.95235161327 369710.33262970654 0.039050889496034684 0.0367740014246401 1.7335432809024731e-07 6.7610653109603 -0.13812720393716593 LHPPS(ph)PVPQGVCPAHR ddPTM_A459_Selumetinib_30min_R2 3 LHPPSPVPQGVCPAHR 16 0 Q96F44-2;Q96F44-3;Q96F44 Q96F44-2 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 LHPPS(1)PVPQGVCPAHR;LHPPS(1)PVPQGVCPAHR;LHPPS(1)PVPQGVCPAHR 94.281 0.0061787 32124200.0 78014.0 55702.0 73155.0 77491.0 81966.0 67509.0 78237.0 84480.0 77778.0 60471.0 True False 73678.294194786 59974.16428984055 68448.28694514153 66936.59212056905 71668.69829466272 76807.75196431387 81875.17552367445 84725.82281358313 93335.77329889529 58725.04510747323 1.254631547067298 1.021270638108175 1.165572317907525 1.1398304079301735 1.2204111237973714 1.3079215490383587 1.3942122202517506 1.44275449526732 1.5893691205869773 1.0 15.841688295940228 -6.752531646666032 1.712952632295687 1.3932031317611864 1.1366745063181611 0.2791932788116116 0.14980226071754885 0.38552142595787353 2.34141701169753 0.06024286425337729 0.05531638710159208 1.767943384523834e-07 6.752531646666032 -0.25652862544302524 LHQLAMQQSHFPMTHGNTGFSGIES(ph)SSPEVK ddPTM_A459_Selumetinib_30min_R1 1 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK 31 0 H3BRU6;F8VZX2;Q15366;Q15366-2;Q15366-6;Q15366-3;Q15366-5;Q15366-4;F8VRH0 H3BRU6;Q15366;Q15366-5 PCBP2 Poly(rC)-binding protein 2 1 LHQLAMQQSHFPMT(0.005)HGNT(0.072)GFS(0.022)GIES(0.331)S(0.331)S(0.238)PEVK 85.595 6.868200000000001e-07 88603000.0 3217.7 3002.0 3244.6 3914.2 3936.5 3546.2 3161.0 3126.9 875.47 1726.5 True False 3292.6661494457085 2650.5244444080645 2804.0011413120556 3230.658448633929 3580.444270045523 3510.5284476919815 2922.5632250642984 3043.964454397348 1485.6086482010792 1948.1130925341304 1.6901822394523134 1.360559843556222 1.439342075189575 1.6583526187545135 1.8379037047526001 1.8020147090769978 1.5002020346070315 1.5625193763457133 0.7625885036625777 1.0 10.927861716344255 -8.252603506392235 22.272691786615695 0.8812942167568732 1.605053631307902 0.7843177933347341 0.15209311785089252 61.006290778032394 153783.93356771616 0.11737086815036006 0.042570304378415726 5.589802886493072e-09 8.252603506392235 0.7237594145510288 LHQLAMQQSHFPMTHGNTGFSGIESS(ph)SPEVK ddPTM_A459_Selumetinib_30min_R1 2 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK 31 0 H3BRU6;F8VZX2;Q15366;Q15366-2;Q15366-6;Q15366-3;Q15366-5;Q15366-4;F8VRH0 H3BRU6;Q15366;Q15366-5 PCBP2 Poly(rC)-binding protein 2 1 LHQLAMQQSHFPMT(0.004)HGNT(0.032)GFS(0.041)GIES(0.203)S(0.447)S(0.272)PEVK;LHQLAMQQSHFPMT(0.003)HGNT(0.013)GFS(0.013)GIES(0.059)S(0.456)S(0.456)PEVK 82.80799999999998 3.3264e-06 132950000.0 5597.3 7347.5 5792.3 7049.200000000001 6519.700000000001 6008.700000000001 5745.9 5044.7 2041.59 4414.9 True False 5727.706199550133 6487.2512842399165 5005.737474826424 5818.189549872334 5929.994286146526 5948.25793346309 5312.48213694937 4910.898168505004 3464.429118166064 4981.595419767697 1.149773459486846 1.3022437066040242 1.0048462496498465 1.1679369879747579 1.1903805480901648 1.1940467726181727 1.0664218366406606 0.9858083113329202 0.6954457008729983 1.0 12.282392142532252 -7.794834846266207 2.2702028386926845 0.8489180569343406 1.165264828525691 0.6108114415741542 0.09981301292710182 0.19229475809034763 1.9535475600258716 0.06603236491478227 0.027295733637594997 1.6038551896296742e-08 7.794834846266207 0.3163467715913504 LHQLS(ph)GSDQLESTAHSR ddPTM_A459_Selumetinib_30min_R1 2 LHQLSGSDQLESTAHSR 17 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 LHQLS(0.773)GS(0.227)DQLESTAHSR;LHQLS(0.859)GS(0.141)DQLESTAHSR 254.02 6.0213e-31 28857300.0 3120.89 3837.04 3137.93 3514.24 4917.42 3195.41 3847.69 3215.94 1072.62 2698.0699999999997 True False 3193.6006648051753 3387.797573008499 2711.816341415686 2900.5439544548817 4472.640229241012 3163.2670766001447 3557.455645507008 3130.642824354667 1820.1577989347913 3044.3935659273448 1.0490104500770685 1.1127988217175695 0.8907574801649033 0.952749337969171 1.469139955917169 1.0390466961969782 1.1685268571454823 1.0283305218459986 0.5978720423357476 1.0 11.571939160884948 -8.065950991603533 7.963893179666865 0.8009222262849807 1.0967539833177125 0.32051897399991003 0.17139215120213955 0.3836280509096256 42.01133248653808 0.11577275471400485 0.043674714162055595 8.591104632175782e-09 8.065950991603533 0.2958317570327318 LHQLS(ph)GSDQLESTAHSR ddPTM_A459_Selumetinib_30min_R2 2 LHQLSGSDQLESTAHSR 17 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 LHQLS(0.903)GS(0.095)DQLES(0.001)T(0.001)AHSR;LHQLS(0.5)GS(0.5)DQLESTAHSR 93.255 0.0038762 39114000.0 54344.0 54014.0 67842.0 82638.0 77097.0 55242.0 48953.0 55314.0 47755.0 75762.0 True False 51323.77803626848 58156.70011761598 63477.11958078461 71382.56184149858 67411.38560407513 62851.084063052745 51229.41149852927 55474.954582274324 57307.33438618551 73574.55420668387 0.6975751139733848 0.7904458374867428 0.8627591463546787 0.9702071947452431 0.9162323350910789 0.8542502872187712 0.6962925164944505 0.7539964758255336 0.778901551006332 1.0 16.166919275352498 -9.957213595232657 15.193195918678663 0.9999999999994943 0.8178283872883866 0.30258064186589784 0.0847463267523287 0.0 0.0 0.09273116861229964 0.02249061193973368 1.1035357441416743e-10 9.957213595232657 -0.1821716127111077 LHQLSGS(ph)DQLESTAHSR ddPTM_A459_Selumetinib_30min_R2 2 LHQLSGSDQLESTAHSR 17 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 LHQLS(0.071)GS(0.929)DQLESTAHSR;LHQLS(0.232)GS(0.768)DQLESTAHSR 108.77 0.0012022 26506900.0 54256.0 45800.0 75511.0 79778.0 100820.0 78411.0 51004.0 66451.0 69119.0 84640.0 True False 51240.668723976545 49312.71272978883 70652.70447016065 68912.09877527377 88154.0902577643 89211.40350581123 53375.7870625087 66644.3614084447 82944.73134622046 82196.22327886998 0.6233944417388929 0.5999389115785025 0.8595614451828859 0.8383852204677739 1.072483463853088 1.085346746445279 0.6493703108647562 0.8107959070374567 1.0091063559552 1.0 16.326784486570524 -5.347856395163833 2.5231151488040497 0.9166212877328025 0.5994844730810993 0.4856343992432649 0.12594117190520757 0.27473013038900124 3.337541614744127 0.03748614631751886 0.10719047269772876 4.48893797675655e-06 5.347856395163833 -0.3171368146517032 LHQVIHTGEKPYK ddPTM_A459_Selumetinib_30min_R1 1 LHQVIHTGEKPYK 13 1 Q86WZ6-2;Q86WZ6 Q86WZ6-2 ZNF227 Zinc finger protein 227 0 97.911 0.03659 9470000.0 4846.4 5793.0 5546.7 6610.5 5793.6 4841.9 4627.1 4863.1 2503.2 4197.5 False True 4959.311690547186 5114.752866907365 4793.488605842187 5456.100269453423 5269.569902943155 4793.194882093452 4278.074121700421 4734.114790424936 4247.747573505597 4736.290012112377 1.0470878425654815 1.0799070271936737 1.0120766662479563 1.1519776566680324 1.112594433505337 1.0120146506729 0.9032542582400708 0.9995407330037058 0.8968512406635989 1.0 12.209541707315262 -6.986908270636679 4.894107607314643 0.9502012391419759 1.0801112513242506 0.6338388746676988 0.04688404499162105 0.12026148013314171 7.923093845008257 0.017228403542156108 0.014500660916696502 1.0306037760856485e-07 6.986908270636679 0.12991001218227471 LHS(ph)PGATSTAELGSR ddPTM_A459_Selumetinib_30min_R2 2 LHSPGATSTAELGSR 15 0 Q9BV73;Q9BV73-2;H7C0P0 Q9BV73 CEP250 Centrosome-associated protein CEP250 1 LHS(0.976)PGAT(0.008)S(0.008)T(0.008)AELGSR;LHS(1)PGATSTAELGSR 91.845 0.010294 6510400.0 27504.0 27402.8 26670.0 30432.0 30363.0 24949.3 27035.7 44664.3 27477.0 33741.0 True False 25975.437787235558 29504.506646110414 24954.081236100443 26287.10910187186 26548.528491335983 28385.839607804228 28292.913620223248 44794.265718427094 32973.167771525914 32766.809660353807 0.792736249164487 0.9004387962069247 0.7615657885147612 0.8022480483865337 0.8102262248453919 0.8662985472812041 0.8634625681747787 1.367062163901355 1.0062977785543092 1.0 14.999947591299536 -7.624183821644855 8.556107068987062 1.139083672398893 0.8252168127634985 0.644125446961207 0.10111518341408435 0.1416787753289981 10.763861725658304 0.04432935258660532 0.0254984666232804 2.375834466249654e-08 7.624183821644855 -0.3138668596353946 LHS(ph)SNPNLSTLDFGEEK ddPTM_A459_Selumetinib_30min_R1 2 LHSSNPNLSTLDFGEEK 17 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 LHS(0.644)S(0.356)NPNLSTLDFGEEK;LHS(0.867)S(0.133)NPNLSTLDFGEEK 142.27 0.00033026 145854000.0 11189.8 13578.8 13380.900000000001 13371.099999999999 12666.7 11565.9 12539.2 12995.6 6690.9 11024.9 True False 11450.50056843943 11988.987783387141 11563.847276022456 11036.088391632804 11520.999221487522 11449.557546996975 11593.35804863217 12650.914472341989 11353.968615998949 12440.053306620068 0.9204543008144475 0.9637408689404178 0.9295657334417263 0.8871415676136908 0.9261213708269671 0.9203784955570895 0.931937971878519 1.0169501818460625 0.9126945308149804 1.0 13.602705047094464 -7.555044987233005 24.350317273981286 0.9737823182327245 0.9250455389216585 0.37077757602920725 0.030464797714643128 162.2189004260653 122799.84611373658 0.013849574159438341 0.007996156807482594 2.7858325778328488e-08 7.555044987233005 -0.048736779311066014 LHS(ph)SNPNLSTLDFGEEK ddPTM_A459_Selumetinib_30min_R2 2 LHSSNPNLSTLDFGEEK 17 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 LHS(0.837)S(0.163)NPNLSTLDFGEEK;LHS(0.5)S(0.5)NPNLSTLDFGEEK 93.342 0.0048875 62790400.0 133771.0 98297.0 114962.0 123416.0 116819.0 112247.0 124388.0 128321.0 99962.0 102931.0 True False 126336.54334774167 105836.06382532844 107565.4700811616 106606.52789552526 102143.15284488944 127708.00537318502 130172.28847014596 128694.39286531502 119957.19317164458 99959.11458314455 1.2638821769740343 1.0587935304018277 1.0760946666018154 1.066501322466712 1.0218493158012945 1.2776024068016263 1.3022553172164257 1.2874703162588428 1.2000625823057478 1.0 16.609050501940814 -6.768732012390671 24.99970793849011 1.2369936053877153 1.0923751389133052 0.2310456295752905 0.1012110448449975 198.56491306310957 680691.9569710579 0.03417587521862544 0.03074395395474718 1.703209173730443e-07 6.768732012390671 -0.14461846647441012 LHS(ph)SSLELGPRPLEQENER ddPTM_A459_Selumetinib_30min_R2 1 LHSSSLELGPRPLEQENER 19 1 Q86X02 Q86X02 CDR2L Cerebellar degeneration-related protein 2-like 1 LHS(0.354)S(0.293)S(0.354)LELGPRPLEQENER 64.275 0.014218 7567700.0 0.0 803.22 1800.2 2035.2 1620.2 1410.1 1298.8 1174.0 1260.5 699.91 True False 0.0 864.8243912406322 1684.377091909561 1758.002249084175 1416.655991228224 1604.3284753866735 1359.1967735233752 1177.4161456338372 1512.6352213126756 679.7017797154272 0.0 1.272358579968278 2.478111934052555 2.5864317286622422 2.084231693230728 2.360341731131501 1.9996957696542068 1.7322540278278948 2.225439547835192 1.0 9.408758090113723 -4.919414906588422 3.108872128933046 2.108678587211452 4.989561060457273e-22 0.6808976090760009 0.43206386281304565 0.15468489707710303 2.644575332677599 0.10764808326605453 0.6814448203258364 1.203885249724796e-05 4.919414906588422 -2.108678587211452 LHS(ph)Y(ph)VKAEEDPMEDPY(ph)ELK ddPTM_A459_Selumetinib_30min_R1 1 LHSYVKAEEDPMEDPYELK 19 1 Q9Y6V0-6;Q9Y6V0;E9PE96 Q9Y6V0-6 PCLO Protein piccolo 3 LHS(1)Y(1)VKAEEDPMEDPY(1)ELK 78.078 0.019131 3940100.0 699.37 1567.4 1300.7 973.26 1393.4 1362.5 1717.9 1444.7 676.0 1486.6 True False 715.6639602628724 1383.8880793355097 1124.0720842336768 803.2984113528838 1267.367216024751 1348.7944870510182 1588.3174199107762 1406.381862953035 1147.1226269134631 1677.4195907102446 0.4266457624713024 0.8250100851329337 0.6701198021406962 0.4788893701979212 0.7555457340808382 0.8040889080590256 0.9468814056465494 0.8384198388654515 0.6838614698828898 1.0 10.712027895281896 -6.559369579115205 3.400558495999469 0.8497613401863546 0.6201007695806244 0.4601273940701306 0.12852629828791742 0.24362085299356945 5.879584206192735 0.04357402315132936 0.045163969464446174 2.7582296386481206e-07 6.559369579115205 -0.2296605706057302 LHSS(ph)NPNLSTLDFGEEK ddPTM_A459_Selumetinib_30min_R1 3 LHSSNPNLSTLDFGEEK 17 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 LHS(0.077)S(0.923)NPNLSTLDFGEEK;LHSS(1)NPNLSTLDFGEEK;LHS(0.002)S(0.998)NPNLSTLDFGEEK 294.94 2.829799999999999e-76 56395000.0 6748.8 7279.400000000001 7307.4 7203.700000000001 7092.900000000001 7402.3 7637.8 7416.9 3812.2699999999995 5711.400000000001 True False 6906.033909121168 6427.124463898754 6315.095216675003 5945.709025196524 6451.348447353207 7327.839582750646 7061.674596771943 7220.179718513442 6469.143752815667 6444.513823747137 1.0716144146783257 0.9973016801074572 0.9799180185485451 0.9226000886657133 1.0010605336248772 1.1370663145679936 1.0957652958630726 1.120360653414705 1.0038218444000804 1.0 12.653855809963456 -6.634867343750244 7.7462513914327 1.0801949457458213 0.9885882912651462 0.33296937785252767 0.0536385818810504 0.24351272974014618 15.673505054327219 0.01785245269310783 0.017832218540622675 2.3181026116204434e-07 6.634867343750244 -0.09160665448067506 LHSS(ph)NPNLSTLDFGEEK ddPTM_A459_Selumetinib_30min_R2 2 LHSSNPNLSTLDFGEEK 17 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 LHS(0.026)S(0.973)NPNLSTLDFGEEK;LHS(0.097)S(0.903)NPNLSTLDFGEEK 136.34 0.00051423 58798200.0 113007.0 86268.0 92740.0 113046.0 96007.0 100847.0 108168.0 105041.0 84964.0 86393.0 True False 106726.52334286386 92884.47820465993 86773.20936767726 97648.93978477267 83945.74234653008 114737.75885208129 113198.02633082583 105346.65191952641 101959.17409251115 83898.60961402873 1.2720892972345286 1.1071039035327312 1.0342627817895074 1.1638922293706848 1.0005617820452353 1.367576404185081 1.349224103374151 1.2556424046139538 1.2152665528257158 1.0 16.356359281757257 -6.762770687737357 24.99996855989648 1.260499669928846 1.1132771682218279 0.20241310182593675 0.11663470577230495 47.81273180261358 897839.8529391262 0.038916557955121944 0.03620949607432658 1.7267493939976206e-07 6.762770687737357 -0.14722250170701812 LHSS(ph)SLELGPR ddPTM_A459_Selumetinib_30min_R2 2 LHSSSLELGPR 11 0 Q86X02 Q86X02 CDR2L Cerebellar degeneration-related protein 2-like 1 LHS(0.026)S(0.829)S(0.145)LELGPR;LHS(0.041)S(0.78)S(0.18)LELGPR 84.29700000000003 0.024131 4681600.0 8429.1 7807.7 8269.2 9648.099999999999 9551.5 10559.0 8074.0 8933.5 8066.799999999999 7810.8 True False 7960.644366360787 8406.525484287602 7737.168674824209 8334.012136099162 8351.555178506596 12013.406404941423 8449.456998327481 8959.495005979465 9680.38540522419 7585.281909104396 1.0494856304293523 1.1082680360498522 1.020023878814248 1.098708292713035 1.1010210666636484 1.5837785001137632 1.1139278802790231 1.1811683617487756 1.276206411472341 1.0 12.888987084291822 -6.551139403110852 24.99991017467422 1.2469521599317743 1.072342084617529 0.22841489628284872 0.1423241350358314 291.96144863959614 258272.6954640459 0.04564053300114648 0.04564139532704005 2.810998390154721e-07 6.551139403110852 -0.17461007531424544 LHSYS(ph)SPSTK ddPTM_A459_Selumetinib_30min_R1 3 LHSYSSPSTK 10 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 LHS(0.007)YS(0.762)S(0.223)PS(0.008)TK;LHS(0.005)YS(0.774)S(0.216)PS(0.005)TK;LHSYS(0.716)S(0.232)PS(0.046)T(0.006)K 177.04 5.9036e-05 148362000.0 17664.2 20448.199999999997 21556.4 22657.6 21580.0 17965.6 20016.5 17651.4 7542.200000000001 14309.900000000001 True False 18075.74149145006 18054.115237889717 18629.159280829437 18700.875495827513 19628.092810258455 17784.88237545965 18506.639289623407 17183.227532172215 12798.56253950699 16146.715055229744 1.1194686615588427 1.1181293022225092 1.1537429884102437 1.1581845243358342 1.2156090414131095 1.1014551451875234 1.1461550678464043 1.0641933962045584 0.792641877665493 1.0 13.97895306734332 -8.05804348881311 4.654221574091565 0.8985574937171047 1.1438109044867755 0.759596039616268 0.05515268996380634 0.09479960688886889 4.166853207778612 0.0368007310077244 0.013598017000408419 8.748961616326895e-09 8.05804348881311 0.24525341076967078 LHSYS(ph)SPSTK ddPTM_A459_Selumetinib_30min_R2 4 LHSYSSPSTK 10 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 LHS(0.004)YS(0.868)S(0.127)PS(0.001)TK;LHSYS(0.859)S(0.136)PS(0.004)T(0.001)K;LHSYS(0.641)S(0.358)PSTK;LHS(0.014)YS(0.839)S(0.138)PS(0.007)T(0.001)K 163.46 0.00039167 175609900.0 285910.0 253112.0 305666.0 327194.0 326100.0 233834.0 236101.0 264545.0 213603.0 275202.0 True False 270020.26678841346 272524.8765166446 285999.7823439775 282629.61275886744 285132.40262901154 266042.5109662911 247080.1643252562 265314.7821522174 256329.5685664829 267256.2031993325 1.0103423739318012 1.0197139421058918 1.0701333735953178 1.0575231159295813 1.0668878746898387 0.9954586938730992 0.9245067518263437 0.9927357306439503 0.9591155060124086 1.0 18.027863908710188 -6.940290907176099 5.286330891970619 0.9672740596196163 1.045136913638038 0.6571676218986757 0.025995802932536925 0.12146967024388579 6.872609216779272 0.0095708544369942 0.008350490342263575 1.1473848014875181e-07 6.940290907176099 0.07786285401842163 LHSYSSPS(ph)TK ddPTM_A459_Selumetinib_30min_R2 1 LHSYSSPSTK 10 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 LHS(0.001)YS(0.304)S(0.064)PS(0.612)T(0.019)K 126.66 0.0034191000000000004 8153000.0 29189.0 24360.0 29418.0 32389.0 32823.0 24199.0 20520.0 25899.0 22731.0 26629.0 True False 27566.792232824988 26228.33367025448 27525.277907896598 27977.56232585856 28699.48129865697 27532.19259334951 21474.220659608625 25974.36180218974 27277.835157206227 25860.15157954897 1.0659949980581584 1.014237429721668 1.0643896584761114 1.081879285966139 1.1097955559298978 1.0646570461374576 0.8303980969930247 1.0044164560400757 1.0548211627181028 1.0 14.658443111094472 -7.062964185150602 24.999993706214884 0.9691698260270544 1.0671933726965979 0.38841180237710515 0.05799208547199466 234.5752723430527 93137.4211986192 0.022677925750894345 0.017566260019086597 8.650392528000171e-08 7.062964185150602 0.0980235466695435 LHTDDELNWLDHGR ddPTM_A459_Selumetinib_30min_R1 3 LHTDDELNWLDHGR 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 ;; 198.37 4.1844e-05 36196000.0 5610.4 7162.299999999999 6920.3 6763.900000000001 6739.7 5628.299999999999 6379.5 5744.7 3299.23 5557.6 False True 5741.1114040619705 6323.734586337062 5980.561270486903 5582.711839128051 6130.095324990682 5571.684412087522 5898.289178835086 5592.331894584554 5598.552343774713 6270.972095608278 0.9155058125808943 1.0084137658283847 0.9536896639478339 0.8902466402358522 0.9775350984712152 0.8884881525767775 0.9405701522680684 0.8917807015121318 0.8927726448815683 1.0 12.614473384596609 -5.5389455322984675 23.51608353134576 0.9225573105921996 0.9667327711344159 0.1124588413915254 0.04212470687626135 184.96819252193043 270726.0717734952 0.01069861854083377 0.01853969622875805 2.8910424441049535e-06 5.5389455322984675 0.04417546054221633 LHTDDELNWLDHGR ddPTM_A459_Selumetinib_30min_R2 2 LHTDDELNWLDHGR 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 ; 165.51 0.00014101 18642300.0 32468.0 25045.9 30362.0 31972.0 39661.0 25695.5 21788.4 20547.8 24864.0 28661.0 False True 30663.558539702008 26966.839994738373 28408.541975646094 27617.358445223683 34678.43060616136 29234.821884475066 22801.603772895523 20607.590696128576 29837.494758205783 27833.482459778905 1.101678835338436 0.9688633117938841 1.0206607102326555 0.9922351069483477 1.2459249630826408 1.0503472544882295 0.8192149080103521 0.7403885132199254 1.0720000560951293 1.0 14.764533806118234 -7.216502428763457 9.57737314985264 0.8863307854486618 1.0622831048052541 0.311474053383454 0.11134504419666544 0.5963358539389779 124.3448224726739 0.04305608368950341 0.03325183790545679 6.074318658311429e-08 7.216502428763457 0.17595231935659228 LHTS(ph)S(ph)WRADS(ph)SRAS(ph)LTRV ddPTM_A459_Selumetinib_30min_R1 1 LHTSSWRADSSRASLTRV 18 3 A0A0A0MST4 A0A0A0MST4 MRPL55 4 LHT(0.53)S(0.616)S(0.854)WRADS(0.772)S(0.375)RAS(0.493)LT(0.36)RV 55.322 0.042975 0.0 11168.0 12639.0 9470.1 8238.2 11064.0 8956.5 12320.0 12388.0 6432.2 12047.0 True False 11428.192670854856 11159.220004288316 8184.112435535747 6799.553020166578 10063.263153507856 8866.40574185134 11390.692481111095 12059.429998104933 10914.973610699386 13593.349797717163 0.8407193841781428 0.8209323066314655 0.6020673753948543 0.5002117300997051 0.7403078198721744 0.6522605445892626 0.8379606683132677 0.8871566006585196 0.8029642268554307 1.0 13.730613401588677 -7.381058826705273 4.055686521556075 0.8807159535318015 0.6880016164172899 0.44596593158242226 0.1041094566567747 0.25508296266840025 7.167988730148965 0.04992200965986342 0.03245199831095407 4.1585427776369546e-08 7.381058826705273 -0.1927143371145117 LHVGNIS(ph)PTCTNK ddPTM_A459_Selumetinib_30min_R1 2 LHVGNISPTCTNK 13 0 D6R9K7;J3QRR5;E9PB51;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2;Q9BWF3 D6R9K7 RBM4 RNA-binding protein 4 1 LHVGNIS(0.892)PT(0.103)CT(0.005)NK;LHVGNIS(0.997)PT(0.003)CTNK 155.39 0.00036557 160144000.0 6735.0 8503.599999999999 8263.599999999999 9164.7 7724.9 6820.4 7356.6 7336.9 4201.5 5907.4 True False 6891.912395971297 7507.994558783611 7141.448508705627 7564.257187725554 7026.184158941862 6751.792968427718 6801.685739167363 7142.3015783900655 7129.638634581243 6665.672332948814 1.033941071766184 1.126367181547636 1.071377072257966 1.1348078348128487 1.0540848406560606 1.0129200223439134 1.0204050543478151 1.0715050517987879 1.0696053268833838 1.0 12.702534684731228 -6.506960286292548 23.85353617343794 1.0379011814661345 1.092882284669354 0.3866598922816171 0.03364011902926547 411.41284422793416 616495.8182972585 0.010395139337073528 0.011441981725944706 3.112000898498903e-07 6.506960286292548 0.05498110320321947 LHVGNIS(ph)PTCTNK ddPTM_A459_Selumetinib_30min_R2 2 LHVGNISPTCTNK 13 0 D6R9K7;J3QRR5;E9PB51;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2;Q9BWF3 D6R9K7 RBM4 RNA-binding protein 4 1 LHVGNIS(0.958)PT(0.042)CTNK;LHVGNIS(0.852)PT(0.148)CTNK 163.9 0.00024004 103546000.0 401880.0 362910.0 407230.0 420840.0 436260.0 255970.0 337730.0 360320.0 293850.0 368980.0 True False 379545.11845310533 390744.0300604301 381029.2651584988 363520.8660105072 381453.1185861163 291227.5440356902 353435.1141992995 361368.47154581314 352628.2108550025 358326.5886748268 1.0592156162810846 1.0904689811199622 1.0633574990000927 1.0144959305277625 1.0645403680391585 0.8127433275680599 0.9863491166156073 1.0084891352389895 0.9840972509438997 1.0 18.45091557331927 LHVGNIS(ph)PTCTNQELR ddPTM_A459_Selumetinib_30min_R1 1 LHVGNISPTCTNQELR 16 0 E9PLB0;E9PM61;U3KQD5;Q9BQ04 E9PLB0 RBM4B RNA-binding protein 4B 1 LHVGNIS(0.959)PT(0.031)CT(0.01)NQELR 93.181 0.019017 0.0 1162.4 1281.1 1276.3 1276.1 1440.8 1155.8 1164.8 1442.9 723.42 1039.9 True False 1189.4816583633317 1131.1082164327677 1102.9854702140713 1053.2530903637412 1310.4798943939002 1144.1737013824347 1076.9381982141404 1404.6296048002596 1227.5909034936947 1173.3812944837773 1.0137213401604783 0.9639732811067119 0.9400060111741628 0.8976221926454981 1.1168406216757005 0.9751081824478953 0.9178075390130822 1.1970785723307602 1.04619948286611 1.0 10.196456183172623 -7.74609511381911 24.998339768440307 1.091229323754945 0.9757226112028546 0.30246153594277425 0.07333533441252886 258.6829251348612 421438.68164435745 0.034322899896308906 0.019722334661590558 1.7943406094554434e-08 7.74609511381911 -0.11550671255209044 LHVGNIS(ph)PTCTNQELR ddPTM_A459_Selumetinib_30min_R2 1 LHVGNISPTCTNQELR 16 0 E9PLB0;E9PM61;U3KQD5;Q9BQ04 E9PLB0 RBM4B RNA-binding protein 4B 1 LHVGNIS(0.988)PT(0.012)CTNQELR 149.22 0.00026566 3884000.0 18545.0 17357.0 21153.0 20411.0 23456.0 15672.0 17413.0 17957.0 12926.0 21709.0 True False 17514.343141516987 18688.22608844857 19792.03900964501 17630.986589061064 20509.247580699426 17830.675743748652 18222.73900320492 18009.251897058628 15511.56118261614 21082.20476324413 0.8307643027949548 0.8864455258982517 0.9388030916079296 0.8362970944955382 0.9728227104812287 0.8457690238753219 0.8643659051720928 0.8542394924679293 0.73576560690938 1.0 14.363738130522195 LHVGNISPT(ph)CTNK ddPTM_A459_Selumetinib_30min_R2 3 LHVGNISPTCTNK 13 0 D6R9K7;J3QRR5;E9PB51;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2;Q9BWF3 D6R9K7 RBM4 RNA-binding protein 4 1 LHVGNIS(0.393)PT(0.606)CTNK;LHVGNIS(0.059)PT(0.928)CT(0.013)NK;LHVGNIS(0.097)PT(0.883)CT(0.021)NK 116.9 0.0087005 109987500.0 146660.0 135384.0 137314.0 154095.0 146169.0 123119.0 119782.0 130292.0 109289.0 131759.0 True False 138509.2243264968 145767.517471828 128479.36673617917 133106.99517129798 127805.94345256028 140077.52468699537 125352.10034353012 130671.12814899826 131149.85378979833 127954.77531900506 1.082485776565809 1.1392112338786409 1.0040998189857804 1.0402659442716997 0.998836840078272 1.0947424536346297 0.979659415062969 1.0212290070708268 1.024970373030843 1.0 16.965274464725383 -5.265422558873085 24.99975709355657 1.0223623278124683 1.1108485077093606 0.5566074619302079 0.032228837669532544 217.11694228717784 1362704.9792576435 0.00795058903886446 0.017600057311604016 5.42722018060939e-06 5.265422558873085 0.08848617989689234 LHYTPPLQS(ph)PIIDNDPLLGQSPWR ddPTM_A459_Selumetinib_30min_R1 2 LHYTPPLQSPIIDNDPLLGQSPWR 24 0 H0Y322;Q5TKA1;Q5TKA1-2;C9J5J4;H7C4T7;Q5TKA1-3 H0Y322 LIN9 Protein lin-9 homolog 1 LHYTPPLQS(1)PIIDNDPLLGQSPWR;LHYTPPLQS(1)PIIDNDPLLGQSPWR 124.39 9.832e-08 27384000.0 2495.7 2544.3 2845.9 3240.2 3502.5 2656.3999999999996 3249.4 2390.3 1153.19 1832.71 True False 2553.8449542131493 2246.4121731870205 2459.4424114097196 2674.3598960869786 3185.6994934166005 2629.6790278182198 3004.295141893051 2326.9014792113517 1956.879204334818 2067.956180607139 1.2349608653039044 1.0862958288252937 1.1893106993629057 1.293238184235511 1.5405062850419293 1.2716318906942035 1.4527847205210167 1.1252179814217282 0.9462865909278072 1.0 11.013989900348514 -7.990056387589688 5.97155417359823 0.9904684615666356 1.2923606848971283 0.5366967682745355 0.1209841606339314 0.13049485260445204 17.81767376729543 0.07995910896833144 0.03513873121398038 1.0231601393846764e-08 7.990056387589688 0.3018922233304927 LIAPVAEEEATVPNNK ddPTM_A459_Selumetinib_30min_R1 1 LIAPVAEEEATVPNNK 16 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 191.29 1.0584000000000001e-13 0.0 1613.1 2109.3 1879.9 2150.7 1878.4 2041.1 1822.0 1716.3 1267.9 1516.1 False True 1650.6820914537934 1862.3421754130343 1624.619905551542 1775.1206186390548 1708.499051658456 2020.568387170521 1684.565073099385 1670.7781486719002 2151.5336962479014 1710.706203064579 0.9649126708588197 1.0886394005451157 0.9496779181844193 1.0376536984895963 0.9987098010154115 1.181131151305146 0.9847191002649288 0.9766598996828613 1.2576874348112017 1.0 10.740376297103959 LIAPVAEEEATVPNNK ddPTM_A459_Selumetinib_30min_R2 2 LIAPVAEEEATVPNNK 16 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 ; 228.61 5.0899e-14 12979100.0 103621.0 106038.0 130464.0 123946.0 135310.0 113746.0 99613.0 106235.0 86250.0 103422.0 False True 97862.15964772896 114170.77363409042 122070.08827846307 107064.34098122381 118311.14811325211 129413.4790166177 104245.20187941492 106544.12626184901 103502.41002635329 100435.93813737304 0.974373928920505 1.1367521999737913 1.2154024798523764 1.0659963252873155 1.1779762334815844 1.288517650321642 1.0379272978645522 1.06081675780358 1.0305316199146368 1.0 16.615916063400164 -7.436990778216375 24.99999999990598 1.0372592146151072 1.1458181113876518 0.31416987370221916 0.08004659954530155 102.82271609528281 29927.247396514475 0.03420417650304613 0.023060441656852088 3.656025547139654e-08 7.436990778216375 0.1085588967725446 LIDLES(ph)PTPESQK ddPTM_A459_Selumetinib_30min_R1 3 LIDLESPTPESQK 13 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 LIDLES(0.627)PT(0.373)PESQK;LIDLES(0.965)PT(0.027)PES(0.008)QK;LIDLES(0.783)PT(0.217)PESQK 195.71 0.00012869999999999998 54669700.0 12154.5 13471.4 15186.5 16175.599999999999 12721.099999999999 12288.800000000001 15274.500000000002 14464.7 8139.1 10587.599999999999 True False 12437.676201459997 11894.162225316053 13124.256713473309 13350.835113617848 11570.478751092613 12165.18582933766 14122.332167429495 14081.049168032647 13811.458243655878 11946.621591957342 1.041104056550451 0.9956088534120302 1.098574740352433 1.1175406378156185 0.9685147103748598 1.018295066575764 1.1821193178945983 1.1786636966481163 1.1560974068981957 1.0 13.544315072932882 -7.256200982935992 24.9776418068682 1.1441087477766783 1.0408705950794828 0.31023033871999595 0.06368020318264268 466.8054837301417 2225820.4843015093 0.02483712469642035 0.01866558000453537 5.543691024789431e-08 7.256200982935992 -0.1032381526971955 LIDLES(ph)PTPESQK ddPTM_A459_Selumetinib_30min_R2 1 LIDLESPTPESQK 13 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 LIDLES(0.706)PT(0.293)PES(0.001)QK 136.33 0.0010997 14341000.0 93316.0 71720.0 100470.0 102340.0 88123.0 71126.0 78948.0 91088.0 71362.0 89011.0 True False 88129.87029354548 77220.69338385262 94005.86958346498 88401.11545365296 77052.20091038432 80922.96088245694 82619.23843249417 91353.05099956975 85636.39402087685 86441.0211516477 1.0195375889756664 0.8933338865627303 1.0875145657817473 1.0226755107226992 0.8913846676476425 0.9361638699349681 0.9557873950557711 1.0568252177320376 0.990691605443216 1.0 16.399428494802358 -7.742051471026595 24.997453944079332 1.0178188345709627 0.9711640337282508 0.1014760174492666 0.059151933506647915 546.6046597207156 704756.8588305593 0.02894557832937813 0.01668223063662234 1.811125431799702e-08 7.742051471026595 -0.0466548008427119 LIDLESPT(ph)PESQK ddPTM_A459_Selumetinib_30min_R1 1 LIDLESPTPESQK 13 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 LIDLES(0.225)PT(0.775)PESQK 195.71 0.00047385 41125000.0 5600.9 5646.3 6648.2 6970.5 5690.7 5219.2 6091.5 6225.4 3534.6 4543.4 True False 5731.390072545749 4985.228571106343 5745.41095594859 5753.233027490368 5175.977189774687 5166.699586654442 5632.013250705212 6060.282169050895 5997.958043030069 5126.589646463693 1.117973246893136 0.972425903942817 1.1207081807126416 1.1222339653143356 1.0096336057139002 1.0078239030148273 1.0985886601222625 1.1821274154898005 1.1699703812196953 1.0 12.323783707713293 -7.520192888632664 24.783027320529584 1.133700957026392 1.0576587740084233 0.1255005630878666 0.06736032279806167 159.08996097470384 1468013.8099157747 0.03056829717676798 0.018064856599126433 3.018610729342291e-08 7.520192888632664 -0.07604218301796872 LIDLESPT(ph)PESQK ddPTM_A459_Selumetinib_30min_R2 3 LIDLESPTPESQK 13 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 LIDLES(0.214)PT(0.785)PES(0.001)QK;LIDLES(0.226)PT(0.774)PESQK;LIDLES(0.205)PT(0.795)PESQK 192.4 0.00028080000000000005 29388800.0 169895.0 149061.0 165372.0 165111.0 175765.0 125078.0 138657.0 159743.0 131419.0 162040.0 True False 160452.9160435712 160493.4993933418 154732.14556341994 142622.59696763806 153683.82934096348 142306.3591549638 145104.82524363327 160207.8256831226 157706.47215366203 157361.4841695189 1.0196454163505604 1.0199033152257824 0.9832910917180567 0.9063373907556487 0.9766292568479232 0.9043277642301795 0.9221114430219657 1.0180879173110584 1.0021923279763394 1.0 17.263722944142934 -11.015339801319893 11.147388206157743 1.0000000654415853 0.9702431161595048 0.03203436879626442 0.043787059213728635 7.750096220638652e-08 3.546933036659211e-09 0.04614633389305444 0.01119210533449827 9.652953156796797e-12 11.015339801319893 -0.029756949282080503 LIDLHSPS(ph)EIVK ddPTM_A459_Selumetinib_30min_R1 2 LIDLHSPSEIVK 12 0 P60866;P60866-2;G3XAN0 P60866 RPS20 40S ribosomal protein S20 1 LIDLHS(0.001)PS(0.999)EIVK;LIDLHS(0.007)PS(0.993)EIVK 95.57 0.011851 27701000.0 9721.8 19551.6 16637.4 20048.9 15528.7 14478.3 16021.2 14051.7 6220.8 11172.1 True False 9948.299024670196 17262.489582707745 14378.132462696532 16547.73597946368 14124.131826814664 14332.6614472446 14812.707985257888 13679.003269645717 10556.24325074449 12606.147860469488 0.7891624891903889 1.369370704974806 1.140565113295526 1.3126718933191537 1.120416163854883 1.1369580625171893 1.175038413733648 1.0851057294465427 0.8373885002449389 1.0 13.621839869202471 -8.070339040750493 4.434146911696866 0.9221165497934266 1.1607097931334869 0.2690155211723735 0.1487129168617897 0.2693348935136268 9.931534334381945 0.09988456521899913 0.03626722454702135 8.50473839412414e-09 8.070339040750493 0.23859324334006027 LIDLHSPS(ph)EIVK ddPTM_A459_Selumetinib_30min_R2 3 LIDLHSPSEIVK 12 0 P60866;P60866-2;G3XAN0 P60866 RPS20 40S ribosomal protein S20 1 LIDLHS(0.046)PS(0.954)EIVK;LIDLHS(0.005)PS(0.995)EIVK;LIDLHS(0.181)PS(0.819)EIVK 99.069 0.009726899999999998 7945000.0 114630.0 116989.0 121731.0 110504.0 110122.0 89242.0 82134.0 95458.0 77756.0 111717.0 True False 108259.32350024764 125961.68012107555 113898.95999069161 95453.1645699676 96287.4898568292 101534.27544178256 85953.39374543335 95735.76697607746 93309.37268416399 108491.43993437475 0.9978605092321798 1.1610287428876265 1.0498428268588547 0.879822082071232 0.8875123227700952 0.9358736090441744 0.7922596823991421 0.8824269180498199 0.8600620725525053 1.0 16.72722169174795 -5.712732572796544 4.56370061365982 0.8832793221475371 1.0844584764613523 0.6316665270021483 0.06235908138028058 0.11246842858011578 4.951573075217845 0.016445909616758576 0.02851439846708731 1.937614729235341e-06 5.712732572796544 0.20117915431381517 LIDPHRAPS(ph)DTGSLS(ph)S(ph)PVEQDRR ddPTM_A459_Selumetinib_30min_R2 1 LIDPHRAPSDTGSLSSPVEQDRR 23 2 A0A5F9ZHA4;A0A2R8YE69;Q8IX94;P0CG41;A4FU28 A0A5F9ZHA4 CTAGE4;CTAGE8;CTAGE9 cTAGE family member 4;cTAGE family member 8;cTAGE family member 9 3 LIDPHRAPS(0.956)DT(0.039)GS(0.186)LS(0.821)S(0.998)PVEQDRR 62.362 0.026116000000000004 0.0 17400.0 16916.0 15584.0 18458.0 16766.0 20118.0 26415.0 23795.0 12342.0 9154.7 True False 16432.977657718813 18213.402806487065 14581.342406576268 15943.988558173985 14659.705190058266 22889.071886979007 27643.34984032953 23864.239510525706 14810.744864292774 8890.380024232856 1.8483999123689656 2.0486641467341196 1.640125885151291 1.7933978654134957 1.6489402196643714 2.5745886930130513 3.1093552542164646 2.6842766502082043 1.6659293330456681 1.0 13.118029373836162 -6.758130436101396 24.999309334397303 2.3685051250703313 1.8011539632959845 0.08416026893640405 0.5630375794142846 146.7413399780047 1108642.9589611888 0.1869958607231912 0.1797046531954739 1.7452978910387712e-07 6.758130436101396 -0.5673511617743467 LIEDNEY(ph)TAR ddPTM_A459_Selumetinib_30min_R1 1 LIEDNEYTAR 10 0 P12931;P12931-2;Q573B4;J3QRU1;P06241-3;P06239;P06241-2;P06241;P06239-3;P07947 P12931 SRC;LCK;YES1;FYN Proto-oncogene tyrosine-protein kinase Src;Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Fyn;Tyrosine-protein kinase Lck;Tyrosine-protein kinase Yes 1 LIEDNEY(0.998)T(0.002)AR 210.64 0.004280399999999999 19213000.0 1744.6 1503.5 1734.8 1716.2 1659.6 1560.4 1450.7 1878.7 765.95 1095.5 True False 1785.245785599336 1327.4695210418136 1499.2236885742934 1416.497887063907 1509.4894730261772 1544.7037927298418 1341.2725310347287 1828.8707731223567 1299.7612072253955 1236.1180960736401 1.4442356205850595 1.07390185877736 1.2128482653367605 1.1459243995886952 1.2211531226837176 1.249640950679698 1.085068275672929 1.4795275458967183 1.051486270894269 1.0 10.27160086648109 -8.501396309558254 24.765736356096745 0.9999998436874544 1.2267640972939513 0.31049580255842557 0.12724438485948408 655.1568217747846 755289.4200254937 0.11408354787289471 0.029456245430909578 3.1521268797806273e-09 8.501396309558254 0.22676425360649688 LIEDNEY(ph)TAR ddPTM_A459_Selumetinib_30min_R2 2 LIEDNEYTAR 10 0 P12931;P12931-2;Q573B4;J3QRU1;P06241-3;P06239;P06241-2;P06241;P06239-3;P07947 P12931 SRC;LCK;YES1;FYN Proto-oncogene tyrosine-protein kinase Src;Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Fyn;Tyrosine-protein kinase Lck;Tyrosine-protein kinase Yes 1 LIEDNEY(0.993)T(0.007)AR;LIEDNEY(0.712)T(0.288)AR 182.16 0.0020425 60437000.0 163203.0 136110.0 171404.0 161193.0 152168.0 107481.0 98473.0 105701.0 76031.0 117479.0 True False 154132.83061337267 146549.19933737046 160376.05325056487 139238.23532656496 133051.29544081993 122285.53213462545 103052.18962054761 106008.57241025755 91239.32448363653 114087.07602290102 1.3510104385744197 1.2845381304009686 1.4057337504063312 1.2204558148077638 1.1662258345030436 1.0718613921710005 0.9032766305612184 0.9291900196388427 0.7997340949059104 1.0 16.79977584438314 -6.711422406239746 1.065502219491466 0.8876331825407444 1.3409032010155408 0.8997553788642899 0.061435708069882106 0.13646892210903155 0.33150297407445545 0.03149017494700192 0.02998550832881621 1.9434688930822016e-07 6.711422406239746 0.4532700184747964 LIEDTEDWRPR ddPTM_A459_Selumetinib_30min_R1 2 LIEDTEDWRPR 11 1 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4;Q96HC4-6;H0YBI4;Q96HC4-3;Q96HC4-2 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 0 ; 172.56 0.00067824 13488000.0 7317.799999999999 8028.1 9160.1 9437.5 8914.3 7329.799999999999 7990.6 7716.4 4496.4 6451.7 False True 7488.2905020398985 7088.166319837568 7916.208732827633 7789.41778881577 8108.003138947495 7256.068866925911 7387.862608731032 7511.736005600337 7630.062395937425 7279.83853987979 1.028634146350662 0.9736708144016905 1.0874154267930167 1.0699987020514874 1.1137613965654491 0.9967348626176712 1.0148388000996826 1.0318547539825487 1.0481087395192996 1.0 12.829690737792394 -9.754264025873145 13.774395464904647 0.999999520062516 1.0406861083428256 0.08590096345083831 0.039688837384462765 0.0 0.0 0.04072152755941298 0.009876421139056488 1.7609051926416228e-10 9.754264025873145 0.04068658828030958 LIEDTEDWRPR ddPTM_A459_Selumetinib_30min_R2 3 LIEDTEDWRPR 11 1 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4;Q96HC4-6;H0YBI4;Q96HC4-3;Q96HC4-2 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 0 ;; 185.08 6.0681e-05 5426200.0 43771.7 44855.2 45125.5 51960.0 45110.0 39462.7 37114.0 35478.1 36271.8 43148.0 False True 41339.04414599831 48295.44960779964 42222.1744589295 44882.95836400047 39442.878511483264 44898.328718276505 38839.87453999582 35581.33539728437 43527.17351876965 41902.20512803254 0.9865601110892974 1.1525753706811488 1.0076360976688288 1.07113595160112 0.9413079428866623 1.071502766527186 0.9269171973484512 0.8491518593965472 1.0387800209027664 1.0 15.354738548141523 -6.50687096300432 1.0050388642669321 0.9511737072655434 1.0640444199663381 0.20952983812821102 0.07251808839373002 0.7079035195146577 1.5390352083784882 0.03587472369639049 0.04262577150952718 3.112641023466778e-07 6.50687096300432 0.11287071270079474 LIEEDFPGIGDK ddPTM_A459_Selumetinib_30min_R1 1 LIEEDFPGIGDK 12 0 G5E971;P45452 G5E971 MMP13 Collagenase 3 0 132.76 0.025461 25177000.0 2974.2 3196.7 3281.4 3428.8 2983.5 2591.9 2928.8 2563.4 1523.2 2236.0 False True 3043.4930732142266 2822.4288778944892 2835.803903439985 2830.0244465474448 2713.642951779707 2565.8278392569064 2707.8782580095935 2495.4103049033097 2584.7591498736506 2523.0123804844006 1.2062933566064775 1.1186742085477213 1.1239754213554554 1.1216847243548207 1.0755567324083866 1.0169699756940096 1.0732718867949826 0.9890598731125562 1.0244734309933885 1.0 11.30093157033406 -5.098845903925578 0.330207153553155 0.9916880128832589 1.303423381309026 0.8477828887895631 0.025481867382761782 2.070429650871737 0.2141685151241601 0.026523443519031745 0.25495053615746066 7.964418932625798e-06 5.098845903925578 0.311735368425767 LIEGVHPGSLVEKLPDS(ph)PALAK ddPTM_A459_Selumetinib_30min_R1 2 LIEGVHPGSLVEKLPDSPALAK 22 1 E9PNJ4;G0XQ39;Q13586;H0YDB2 E9PNJ4 STIM1 Stromal interaction molecule 1 1 LIEGVHPGS(0.004)LVEKLPDS(0.996)PALAK;LIEGVHPGS(0.243)LVEKLPDS(0.757)PALAK 66.77 0.0026415 24786000.0 3234.6000000000004 3732.2 4128.7 3907.1 4004.7 4010.5 3809.7 3641.8 1718.2399999999998 3027.3999999999996 True False 3309.959886564032 3295.2322889472935 3568.0452173257345 3224.7983303504207 3642.475592087209 3970.158011242651 3522.331261792935 3545.207633766432 2915.7277847156643 3415.9962793731997 0.9689588675931976 0.964647505281222 1.044510861698138 0.944028642484979 1.0662996368238333 1.1622255080357213 1.0311285416385894 1.0378253791356415 0.8535512179336069 1.0 11.738090688270152 -5.248450728047408 22.96648579148421 1.023579179731089 0.9668031539005143 0.06198108162307536 0.07586105275655193 740.2205180606295 1308833.8536814312 0.02007331645772781 0.05224816131643099 5.643509649462196e-06 5.248450728047408 -0.05677602583057462 LIEGVHPGSLVEKLPDS(ph)PALAK ddPTM_A459_Selumetinib_30min_R2 1 LIEGVHPGSLVEKLPDSPALAK 22 1 E9PNJ4;G0XQ39;Q13586;H0YDB2 E9PNJ4 STIM1 Stromal interaction molecule 1 1 LIEGVHPGS(0.028)LVEKLPDS(0.972)PALAK 60.13399999999999 0.0067337 2826700.0 30969.0 10473.0 26845.0 30136.0 17996.0 16653.0 28806.0 19765.0 16983.0 21724.0 True False 29247.866958729566 11276.245423997338 25117.821926626042 26031.42481250033 15735.18159371875 18946.799589117294 30145.53607800613 19822.51287772811 20380.07454466734 21096.77167426947 1.3863669480009364 0.5345009937112953 1.1906002640802535 1.2339056048205412 0.7458573205733678 0.8980899960265308 1.428917018368878 0.9395993464679954 0.9660281136532257 1.0 14.364734627493334 LIESLS(ph)PDFCHQNK ddPTM_A459_Selumetinib_30min_R2 3 LIESLSPDFCHQNK 14 0 Q9H6R7;Q9H6R7-2 Q9H6R7 C2orf44 WD repeat and coiled-coil-containing protein C2orf44 1 LIES(0.208)LS(0.792)PDFCHQNK;LIES(0.006)LS(0.994)PDFCHQNK;LIES(0.001)LS(0.999)PDFCHQNK 116.84 0.0025924 29234400.0 119397.7 110460.2 138086.5 133311.4 142301.8 98431.6 108058.2 106453.3 99066.1 123737.3 True False 112762.05382086296 118932.14215447642 129202.16492721328 115154.15734500781 124424.575689767 111989.65942689947 113083.12041326109 106763.06147870753 118882.08813810682 120164.68264088506 0.9383959691206023 0.9897429056581282 1.075209138722872 0.9583028458465511 1.035450458115158 0.9319681703948169 0.9410678572772718 0.8884728784893596 0.9893263605030165 1.0 16.87465341320018 -6.776666193223427 24.999280479334807 0.9426278971378219 1.0008088273061522 0.21491329648636515 0.04591423106816282 321.82263710091513 528362.7176054817 0.01579155021389324 0.0139793133791423 1.6723755392301508e-07 6.776666193223427 0.05818093016833026 LIEVDDER ddPTM_A459_Selumetinib_30min_R1 2 LIEVDDER 8 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 ; 178.3 0.0038794 48291000.0 8418.2 10713.9 11013.7 11768.400000000001 11121.099999999999 9276.6 9628.2 8398.2 5461.5 7335.7 False True 8614.327681034238 9459.511607243014 9518.100033923622 9713.269860227761 10115.198468589675 9183.285826478881 8901.937122291705 8175.452454801818 9267.766607822316 8277.308550768972 1.0407160284285835 1.1428245726522075 1.1499027703926028 1.1734816698750932 1.2220395562818498 1.1094531235791303 1.0754627627678208 0.9876945391920069 1.1196594340996662 1.0 13.01494602199075 -7.256206245075686 2.856036823779069 1.0405293567565974 1.1479173143401236 0.4320056752218998 0.054230306495136486 0.26041479576238946 4.270293647169381 0.024591600118807046 0.016748290843561792 5.543623854928707e-08 7.256206245075686 0.10738795758352615 LIEVDDER ddPTM_A459_Selumetinib_30min_R2 2 LIEVDDER 8 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 ; 139.97 0.03284 41188000.0 160502.0 148114.0 167719.0 171586.0 181580.0 121941.0 139303.0 136716.0 123753.0 154124.0 False True 151581.94138041302 159473.86753842642 156928.14213864034 148215.69079763992 158768.29705420387 138737.26587981466 145780.8655236577 137113.8209254478 148507.05794772547 149674.03965775683 1.012747045025435 1.0654744664009723 1.0484660031724318 0.9902565009706991 1.0607604192232793 0.9269293873343026 0.9739889820372242 0.9160828506999003 0.9922031789033037 1.0 17.191464488051928 -6.759178606725083 24.99999954250968 0.9573553119947357 1.0354061299271973 0.5690325690965545 0.031950293988081545 40.70788038958521 450155.2117639036 0.01028574404386505 0.009814120024098488 1.7410906900819417e-07 6.759178606725083 0.0780508179324616 LIEVDDERK ddPTM_A459_Selumetinib_30min_R1 1 LIEVDDERK 9 1 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 119.21 0.0094291 2670700.0 724.39 1005.3 984.7 871.22 941.46 1017.0 738.02 640.33 492.91 577.02 False True 741.2668775824274 887.5990086487094 850.9831485699254 719.0777818248557 856.3051092282634 1006.7699033621183 682.3505572166894 623.3463683150258 836.432269277981 651.0861376507642 1.1385081553986873 1.3632589565665247 1.3070208369670189 1.104428032240738 1.315194810195109 1.5462929482644572 1.0480188684076932 0.9573946245640731 1.284672212951698 1.0 9.34670461203022 -7.378773141996187 21.00490512471832 1.068942706394063 1.2920738270514516 0.38185362652958244 0.13907837663876418 6.646636743524517 1170.4193806295775 0.058256608665433335 0.03927649770610497 4.180486814720168e-08 7.378773141996187 0.2231311206573885 LIGTAVPQRT(ph)SPTGPK ddPTM_A459_Selumetinib_30min_R1 1 LIGTAVPQRTSPTGPK 16 1 C9JB30;Q9UPY8 C9JB30 MAPRE3 Microtubule-associated protein RP/EB family member 3 1 LIGT(0.023)AVPQRT(0.656)S(0.319)PT(0.002)GPK 154.51 0.0049324 0.0 1130.6 1066.0 1997.3 2386.2 1603.9 1346.5 1226.1 991.95 660.07 947.37 True False 1156.9407802353599 941.1922244300454 1726.0776303835803 1969.494964521557 1458.8275281915442 1332.955432524182 1133.6142898612272 965.6402636922979 1120.0905803946298 1068.974167665253 1.0822906813194886 0.880463020435474 1.6147047165353934 1.8424158638212296 1.364698579552928 1.2469482171262292 1.0604693023940464 0.9033335817659218 1.0478181926893708 1.0 10.062011274641414 -7.1944686862021605 2.4430695056591674 0.9826340250646454 1.368349699821072 0.31309941244064554 0.24869643754664353 0.41663517564041125 4.872368919009717 0.129314710122008 0.09006523311924335 6.39044812533435e-08 7.1944686862021605 0.38571567475642665 LIHEQEQQSS(ph)S ddPTM_A459_Selumetinib_30min_R2 1 LIHEQEQQSSS 11 0 Q96FQ6 Q96FQ6 S100A16 Protein S100-A16 1 LIHEQEQQSS(0.601)S(0.398) 87.713 0.035927 0.0 22138.0 20307.0 24335.0 26031.0 28412.0 20470.0 16837.0 23017.0 24055.0 24184.0 True False 20907.65858543558 21864.481602703523 22769.31259394466 22485.53289402033 24842.630553497293 23289.556691841153 17619.953861882575 23083.97565933054 28866.67215285715 23485.745082421872 0.8902276045346381 0.9309681905330822 0.9694950070366969 0.9574119456337725 1.0577748530571847 0.9916464906737169 0.750240360697366 0.982893051862679 1.2291145991558379 1.0 14.51949774319684 -8.018766258088293 24.75991099243579 1.1117062061509408 0.938704408954728 0.37693647500866956 0.09081311684048211 714.7282469452114 942995.5014902471 0.05966283484953167 0.023411966685125348 9.577093819904107e-09 8.018766258088293 -0.1730017971962129 LIHPDEDISLEER ddPTM_A459_Selumetinib_30min_R1 4 LIHPDEDISLEER 13 0 J3KS31;J3QRS9;X6R4W8;O43670-3;O43670-2;O43670;O43670-4 J3KS31 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 ;;; 265.53 2.4106999999999997e-30 20301800.0 10024.4 11723.6 10833.6 11956.1 11055.900000000001 9714.599999999999 12167.7 10120.6 5780.7 7854.6 False True 10257.949015913086 10350.99546184623 9362.456624705133 9868.191578793138 10055.895797077683 9616.87994415106 11249.880592728536 9852.168811658124 9809.42569437672 8862.814420282994 1.1574143978956906 1.1679129191916127 1.0563751175110565 1.1134376859126474 1.1346165360367089 1.0850819489283619 1.2693350057045787 1.1116298214606575 1.1068070738260478 1.0 13.11354918947254 -8.7276940642199 2.2207927662467046 1.0002503452837441 1.1367300372653546 0.3666257672921538 0.05407315881901596 0.9317439010167783 7.88989258660166 0.05276615609548787 0.014429356863842311 1.8720003938794213e-09 8.7276940642199 0.13647969198161047 LIHPDEDISLEER ddPTM_A459_Selumetinib_30min_R2 2 LIHPDEDISLEER 13 0 J3KS31;J3QRS9;X6R4W8;O43670-3;O43670-2;O43670;O43670-4 J3KS31 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 ; 155.88 0.00051341 9490300.0 67328.0 64082.0 72192.0 76109.0 84428.0 60718.0 55289.0 66517.0 58227.0 71836.0 False True 63586.17929533866 68996.88334389353 67547.24531670644 65742.82290465198 73821.39984410357 69081.35335687401 57860.048053075065 66710.55345751793 69874.02699831282 69761.90802765687 0.9114741997900937 0.9890337763775031 0.9682539831038962 0.9423885435958613 1.0581906649519581 0.9902446092713941 0.829393141456748 0.9562604484824406 1.0016071660570336 1.0 16.09015187872957 -6.527688721093423 0.0021021823386573883 1.9251103859029577 1.5675719489409032e-05 0.01987916182301286 0.0579946613747263 756039.3493420403 532.1713460136638 242002.2909162983 245332.9769670909 2.966957182803713e-07 6.527688721093423 -1.9250947101834683 LIHTLDDR ddPTM_A459_Selumetinib_30min_R1 2 LIHTLDDR 8 0 Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;H7C3A1 Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 0 ; 134.48 0.0039297 6117400.0 5031.9 4683.5 5325.200000000001 5242.6 5616.1 4462.1 5088.3 5263.0 3257.2 4195.0 False True 5149.133479627016 4135.153642699921 4602.06708922978 4327.078325790257 5108.124746602986 4417.215325262645 4704.485434386166 5123.40814336667 5527.230503524459 4733.469112760312 1.087813896523835 0.8735989491412389 0.9722398054365027 0.9141452542967858 1.0791503282091124 0.933187736105614 0.9938768633144742 1.0823791222288057 1.1676912581143404 1.0 12.208682192818054 -7.742641872301075 4.06295504676425 1.0964693195489588 0.973084142109399 0.29549799272889044 0.07337425069920801 0.2273879497067156 8.327581499079937 0.03782469302654113 0.019088872253513953 1.8086649716425273e-08 7.742641872301075 -0.12338517743955979 LIHTLDDR ddPTM_A459_Selumetinib_30min_R2 2 LIHTLDDR 8 0 Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;H7C3A1 Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 0 ; 148.99 0.002093 5884000.0 37409.0 36538.0 37389.0 45112.0 42913.0 32792.0 31133.0 34038.0 29126.0 31964.0 False True 35329.95754009217 39340.34711181276 34983.43244606522 38967.66777745937 37521.885292912484 37308.80034386202 32580.746188869165 34137.044944705754 34952.01384843552 31041.11626755428 1.1381664639754208 1.267362512762895 1.1270030415314556 1.2553565226708783 1.2087801536999565 1.2019155504036767 1.049599695708243 1.0997363835265002 1.1259908808424233 1.0 14.92189281866947 -7.253376910920831 24.567420786676028 1.0771431045943953 1.202466142062338 0.6065191530945477 0.05146308420212018 323.0820776982725 984475.85822994 0.018758943187572853 0.014258917305245554 5.579857257645261e-08 7.253376910920831 0.1253230374679426 LIIES(ph)PSNTSSTEPA ddPTM_A459_Selumetinib_30min_R1 4 LIIESPSNTSSTEPA 15 0 P38432 P38432 COIL Coilin 1 LIIES(0.63)PS(0.37)NTSSTEPA;LIIES(0.817)PS(0.183)NTSSTEPA;LIIES(0.775)PS(0.225)NTSSTEPA;LIIES(0.824)PS(0.129)NT(0.022)S(0.022)S(0.001)T(0.001)EPA 193.0 2.5014e-05 81431500.0 8313.5 9384.6 10250.900000000001 10739.1 9573.4 8060.700000000001 9996.3 8804.4 4776.78 7280.550000000001 True False 8507.188374744972 8285.846669217823 8858.884084163145 8863.717782873795 8707.487660321052 7979.616676530019 9242.271042932693 8570.878711278261 8105.846777792446 8215.07951106248 1.03555764290402 1.0086142998445782 1.0783686356575992 1.0789570290753552 1.059939547583866 0.9713377290852284 1.1250373207571502 1.0433104998845915 0.9867033869699081 1.0 13.004058823277536 -8.219060617567083 6.071355889744311 0.9932811217098078 1.0510646619410884 0.2490798849152045 0.03949701828648304 0.25917862866331914 26.140856017182347 0.02850541172226016 0.010129330679136477 6.038643378570347e-09 8.219060617567083 0.05778354023128063 LIIES(ph)PSNTSSTEPA ddPTM_A459_Selumetinib_30min_R2 3 LIIESPSNTSSTEPA 15 0 P38432 P38432 COIL Coilin 1 LIIES(0.511)PS(0.489)NTSSTEPA;LIIES(0.796)PS(0.204)NTSSTEPA;LIIES(0.842)PS(0.158)NTSSTEPA 232.6 4.2499e-14 26734100.0 94169.0 92484.4 93885.0 105503.0 111604.0 77327.0 78270.0 84577.0 77655.0 91545.0 True False 88935.46396837503 99577.65609578333 87844.54131425919 91133.30939717365 97583.30776758089 87978.09234538366 81909.71008906262 84823.10506752385 93188.16986198789 88901.85798752538 1.0003780121316965 1.120085208002694 0.9881069226538037 1.0251001661850687 1.0976520623593005 0.9896091525750639 0.9213498113903998 0.9541207235446771 1.04821397405512 1.0 16.439925950251045 -6.94557206381747 10.328056242150078 0.9740196143818233 1.0458187079465417 0.29924360048943477 0.0483499554629304 0.5297429808796635 97.4012470188638 0.01686873943668419 0.014872701939018412 1.1335167345857813e-07 6.94557206381747 0.07179909356471847 LIIESPS(ph)NTSSTEPA ddPTM_A459_Selumetinib_30min_R1 1 LIIESPSNTSSTEPA 15 0 P38432 P38432 COIL Coilin 1 LIIES(0.398)PS(0.602)NTSSTEPA 160.38 0.00012949 5129300.0 1449.5 1719.3 1469.3 1646.4 1649.1 1273.3 1280.4 1227.1 871.57 1285.0 True False 1483.2705297639786 1518.0035567191155 1269.7771302871856 1358.8871467556326 1499.9391961722513 1260.4917580638985 1183.8183971440465 1194.5533218174505 1478.9906330458105 1449.9422669599528 1.0229859240353785 1.0469406895088758 0.8757432342113085 0.9372008649728981 1.0344820137681243 0.8693392742503678 0.8164589888300313 0.8238626799410654 1.0200341535989308 1.0 10.50177974157211 -6.776344817930528 24.99989296248089 0.8893379205644237 0.978441281491082 0.1805189585001371 0.07835210602710391 373.04994835970115 625687.6943780938 0.028176339629242427 0.024949500464638084 1.673613545027749e-07 6.776344817930528 0.08910336092665827 LIIESPS(ph)NTSSTEPA ddPTM_A459_Selumetinib_30min_R2 1 LIIESPSNTSSTEPA 15 0 P38432 P38432 COIL Coilin 1 LIIES(0.208)PS(0.792)NTSSTEPA 196.15 3.2361e-05 16801000.0 48962.0 52199.0 57482.0 71291.0 69041.0 53609.0 53918.0 56716.0 47596.0 62924.0 True False 46240.88805041544 56202.49545376087 53783.67070166951 61581.04281616543 60367.45234562877 60993.15313595079 56425.293836490106 56881.03417016075 57116.52994335432 61107.22062381381 0.7567172517153418 0.9197357510293711 0.8801524623869037 1.0077539476925084 0.987893930199523 0.998133322270289 0.9233817748618216 0.9308398187561144 0.9346936312972431 1.0 15.899055243107068 -3.978628869919602 1.0570542875985198 0.9624257215491074 5.592468859797514e-18 0.7255654664086022 0.03758294084335233 4.516150400984958 1.1904777777386857 0.012248893138387172 7.350303063979871 0.0001050439707485079 3.978628869919602 -0.9624257215491074 LIIS(ph)TPNQR ddPTM_A459_Selumetinib_30min_R1 1 LIISTPNQR 9 0 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 LIIS(0.5)T(0.5)PNQR 96.665 0.021733 0.0 2437.2 3279.5 3511.4 3479.1 2900.3 3130.8 2926.0 2710.8 1556.5 2444.3 True False 2493.9820180343345 2895.534615401811 3034.5711667395512 2871.540495795387 2637.9683770895535 3099.306994538958 2705.2894642638857 2638.9007780806323 2641.266817737878 2758.049714498219 0.904255643008985 1.04984859416452 1.1002597780553933 1.0411489251627994 0.9564615036569374 1.1237313737482157 0.9808704498845728 0.9567995689884568 0.957657435924215 1.0 11.42943274666758 -7.498471965795177 24.85463115571737 0.9681040778190172 1.0324765884796463 0.16659314253273882 0.060640061597242396 1134.9871033196016 1155817.2749955712 0.025417019939057844 0.017034844896829195 3.173423505336397e-08 7.498471965795177 0.0643725106606291 LIIS(ph)TPNQR ddPTM_A459_Selumetinib_30min_R2 1 LIISTPNQR 9 0 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 LIIS(0.648)T(0.352)PNQR 80.755 0.045605 2419200.0 25111.0 20146.0 21152.0 27266.0 22195.0 20209.0 22500.0 21783.0 17664.0 23957.0 True False 23715.431147297535 21691.13342040012 19791.10334855631 23552.32376352649 19406.665674182466 22992.606310963267 23546.29458290417 21846.384923630223 21197.293573397135 23265.2991622387 1.0193477840933776 0.9323384698016879 0.8506704861409533 1.0123370260268842 0.8341464057200226 0.9882789879737272 1.0120778769576944 0.939011562726368 0.9111120138872707 1.0 14.505892117992268 LILIESR ddPTM_A459_Selumetinib_30min_R2 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 143.02 0.045162 4960900.0 28527.0 29353.0 35770.0 30822.0 35462.0 21560.0 25669.0 26310.0 22175.0 30668.0 False True 26941.583542629018 31604.280715229062 33468.59714343131 26623.990429084337 31006.946525697622 24529.69429780632 26862.659362158563 26386.55774414503 26610.61962126822 29782.53515496668 0.9046101482779954 1.0611682501433588 1.1237658906229788 0.8939464115647787 1.0411117241819743 0.8236268057830405 0.9019601327551464 0.885974199538372 0.8934974636244323 1.0 14.862178944074854 -6.749565509108706 24.999959975144083 0.8939443775311864 1.0084826670377238 0.31746632178230483 0.07573576323213776 250.81607325653812 528082.443899952 0.024696108532042876 0.024510421073300613 1.7800593839156123e-07 6.749565509108706 0.11453828950653744 LIPGPLS(ph)PVAR ddPTM_A459_Selumetinib_30min_R1 4 LIPGPLSPVAR 11 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 LIPGPLS(1)PVAR;LIPGPLS(1)PVAR;LIPGPLS(1)PVAR;LIPGPLS(1)PVAR 150.09 0.00061975 441847000.0 9912.4 13544.699999999999 14032.5 15132.5 12843.0 11997.3 13027.599999999999 11792.8 6201.3 9350.500000000002 True False 10143.339633827149 11958.880227239802 12126.963575005047 12489.892947205792 11681.352917615806 11876.618054676836 12044.91764341906 11480.016635587006 10523.153174968145 10550.727756582908 0.9613876756035546 1.133464961199317 1.1493959331325443 1.1837944486258762 1.107160869573899 1.1256681367090213 1.1416196040035136 1.0880781781545152 0.9973864758667895 1.0 13.365054894557911 -8.173396655922387 3.3371812090614874 0.9961610570924412 1.119354512603013 0.39947307773021634 0.055694910982144 0.24501666339913902 4.920354848270462 0.04631852631327049 0.014715295815668791 6.708158940773296e-09 8.173396655922387 0.12319345551057193 LIPGPLS(ph)PVAR ddPTM_A459_Selumetinib_30min_R2 4 LIPGPLSPVAR 11 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 LIPGPLS(1)PVAR;LIPGPLS(1)PVAR;LIPGPLS(1)PVAR;LIPGPLS(1)PVAR 114.71 0.0063881 217207300.0 178190.0 153938.0 172009.0 172498.0 189337.0 120539.0 138832.0 156955.0 118200.8 147998.0 True False 168286.913151087 165744.549611315 160942.12820923896 149003.47482435263 165550.7933657438 137142.15310590327 145287.96309038915 157411.71306470115 141844.26280629556 143724.91319501642 1.1708959108762382 1.1532068165970693 1.1197928364086815 1.0367268381799186 1.1518587117955843 0.9541988932692471 1.0108752884981873 1.0952291399272824 0.9869149311214469 1.0 17.13295063384951 -5.410253651875026 0.5510888843609301 1.0146974852026365 1.2263222990754574 0.5503915369642234 0.05048803159314192 1.7717185041755004 0.6634761595514476 0.03193880852093378 0.22156458415973293 3.888179875645872e-06 5.410253651875026 0.21162481387282095 LIPITGGNARS(ph)PEDQLGK ddPTM_A459_Selumetinib_30min_R1 1 LIPITGGNARSPEDQLGK 18 1 Q9UK61-3;Q9UK61;Q9UK61-2 Q9UK61-3 FAM208A Protein FAM208A 1 LIPIT(0.005)GGNARS(0.995)PEDQLGK 72.568 0.01075 26144000.0 1690.5 1777.6 3854.1 4629.7 2629.3 2221.8 1734.6 1508.0 1305.4 1337.8 True False 1729.8853608596105 1569.4777656161807 3330.7343890559064 3821.2098052323595 2391.4802792406167 2199.4507092329945 1603.757725465527 1468.002941325657 2215.1684573562666 1509.5196612755055 1.145983987646707 1.0397199889996875 2.206486258179321 2.531407773783837 1.584265737366996 1.4570533697948094 1.0624291730724413 0.9724967345474865 1.4674657867553085 1.0 10.55987383253048 -6.969187896120938 2.650060351103407 1.127442950956842 1.7398720272167238 0.28120427386381786 0.4324259710202282 0.41196909385051 5.86125827119842 0.19617496913519458 0.1603757988516379 1.0735248547530573e-07 6.969187896120938 0.6124290762598819 LIQFIS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 LIQFISK 7 0 B5MC47;B6ZDM2;Q63HM2 B5MC47 PCNXL4 Pecanex-like protein 4 1 LIQFIS(1)K 69.383 0.046202 3232000.0 8661.4 10601.0 44342.0 54070.0 81465.0 46148.0 18464.0 28995.0 60416.0 38358.0 True False 8180.034062331363 11414.062612412472 41489.08399591921 46705.57272404745 71230.6383936596 52504.46811016541 19322.6125857219 29079.37064961936 72500.88816408296 37250.504873947146 0.21959525354117942 0.3064136352255301 1.1137858167645 1.2538238845915117 1.9122059857899543 1.4094968185756545 0.5187208240830061 0.780643665046198 1.9463061885851054 1.0 15.184972358794148 -5.280124954718237 3.3925835876069614 1.2504063094668447 0.2238126204675601 0.46799354603293686 0.42034923273859204 0.2196805055899134 5.310030471397653 0.12006683305957974 0.32308510974358756 5.246564849598104e-06 5.280124954718237 -1.0265936889992846 LIQNLDANHDGR ddPTM_A459_Selumetinib_30min_R2 3 LIQNLDANHDGR 12 0 Q96FQ6 Q96FQ6 S100A16 Protein S100-A16 0 ;; 176.87 0.00014555 11720400.0 82920.0 69650.0 75530.0 84459.0 83924.0 66893.0 72420.0 79124.0 58575.0 72126.0 False True 78311.6383550601 74991.93103995192 70670.48203084596 72955.53850009853 73380.71682992076 76106.90355580518 75787.67349750761 79354.23774031672 70291.63672224517 70043.53497414646 1.1180423487187712 1.0706474347365813 1.0089508197570398 1.0415741942068872 1.0476443951180658 1.0865657135079883 1.082008118600544 1.1329273682375811 1.0035421077504196 1.0 16.095964275442242 -6.738938745941862 24.533453180354424 1.070629100939989 1.0545416685660294 0.0 0.045099504420461727 918.6962530657813 1001696.7108438581 0.014842519936983812 0.014828040076854962 1.8241529676019036e-07 6.738938745941862 -0.01608743237395971 LIQYCHSK ddPTM_A459_Selumetinib_30min_R1 1 LIQYCHSK 8 0 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 0 96.331 0.029737 22357000.0 2341.0 2480.4 2459.3 3292.3 2389.6 2051.3 2123.4 2231.3 1384.1 1496.0 False True 2395.5407452069485 2189.993614893325 2125.340567967928 2717.361609125104 2173.4611019181452 2030.6657844313795 1963.2302284408515 2172.1186757161395 2348.716609335687 1688.026172274 1.4191372056630085 1.2973694666967792 1.2590684924658522 1.6097864202333132 1.2875754757938371 1.2029824050037077 1.163033050486483 1.2867802119383027 1.391398218767928 1.0 10.721121557378506 -6.514158758191231 24.639116370500638 1.226275126234332 1.3881177846319148 0.32080228294141744 0.12714448881452145 483.5186388042559 1366230.2684888658 0.040859290987277745 0.04291047920263022 3.060844324520946e-07 6.514158758191231 0.16184265839758272 LIQYCHSK ddPTM_A459_Selumetinib_30min_R2 2 LIQYCHSK 8 0 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 0 ; 117.81 0.012191 63738000.0 264446.0 244282.0 269789.0 254725.0 279931.0 190477.0 189636.0 214762.0 154329.0 249579.0 False True 249749.14998121338 263017.6439095692 252431.0694640528 220031.01557486603 244763.5651651081 216713.47777195068 198454.44975660523 215386.9218642369 185199.1123125459 242373.00578588166 1.0304330268604582 1.085177134544123 1.0414982833816762 0.9078198079915174 1.0098631420255535 0.8941320716359014 0.8187976590591315 0.8886588717495837 0.7641078333457456 1.0 17.88686950250728 -6.228028653319221 0.8622219632969056 0.8578335258168472 1.0662963330556456 0.5235386704829346 0.06877611675852047 0.4660511522193701 0.7388658881006751 0.03395196797289083 0.05862350477592707 5.915226061751142e-07 6.228028653319221 0.2084628072387984 LIRPEYAWIVQPVSGAVY(ph)DRPGASPK ddPTM_A459_Selumetinib_30min_R1 1 LIRPEYAWIVQPVSGAVYDRPGASPK 26 2 G3V198;Q12769 G3V198 NUP160 Nuclear pore complex protein Nup160 1 LIRPEYAWIVQPVS(0.219)GAVY(0.573)DRPGAS(0.207)PK 85.01299999999998 0.00026405 26844000.0 1760.4 1649.3 2109.3 2399.6 1419.4 1943.5 1584.4 1652.0 939.87 1690.8 True False 1801.4138948578868 1456.1991892612323 1822.868645555544 1980.554906070711 1291.015520615424 1923.9501545568114 1464.8874323922416 1608.1835935477372 1594.890744611179 1907.830649786683 0.944221068604441 0.7632748689848609 0.9554666949916971 1.0381188216533577 0.67669293433344 1.0084491276895728 0.7678288597345014 0.8429383361293364 0.8359708157479836 1.0 10.897717399634299 -6.223725090131582 24.999850567177912 0.8507425577325839 0.9158560664513278 0.08255361295890684 0.11189237194512529 1644.1021839258099 1089833.3904365327 0.031898358650662074 0.041179669571468965 5.974133315684803e-07 6.223725090131582 0.06511350871874388 LIRPEYAWIVQPVSGAVYDRPGAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 LIRPEYAWIVQPVSGAVYDRPGASPK 26 2 G3V198;Q12769 G3V198 NUP160 Nuclear pore complex protein Nup160 1 LIRPEYAWIVQPVS(0.109)GAVY(0.174)DRPGAS(0.717)PK;LIRPEYAWIVQPVS(0.105)GAVY(0.089)DRPGAS(0.806)PK 77.43 0.00019613 119977000.0 7756.4 10948.0 10858.099999999999 11526.9 7874.0 9254.7 7626.9 9037.2 5602.6 8585.7 True False 7937.109028672865 9666.203070412885 9383.629659273998 9513.943301711319 7161.798090267606 9161.606120595281 7051.596792547578 8797.504099037289 9507.203002286054 9687.75822680005 0.8192926415851071 0.9977750109073186 0.9686069201557161 0.9820582924326196 0.7392626779697422 0.9456889722176147 0.7278873633572068 0.9081052492309338 0.981362538134518 1.0 13.241947145426261 -4.49202613685993 13.8333931646726 0.9070893160902205 0.5847396736039692 0.07612576355218525 0.0967200374189934 459414.13191033364 7005197.088214794 0.024360975427683347 3315679.912688667 3.220874945646324e-05 4.49202613685993 -0.3223496424862513 LIS(ph)PQNLSVR ddPTM_A459_Selumetinib_30min_R2 1 LISPQNLSVR 10 0 Q7Z333-3;Q7Z333;Q7Z333-4 Q7Z333-3 SETX Probable helicase senataxin 1 LIS(0.547)PQNLS(0.453)VR 85.973 0.035713 2072900.0 10705.0 12328.0 12263.0 11319.0 11866.0 11077.0 10548.0 10209.0 8557.7 11378.0 True False 10110.058955510342 13273.517959232246 11474.011930944871 9777.332673635894 10375.286996614068 12602.7562030056 11038.502900465484 10238.706499809074 10269.479122116218 11049.48757640572 0.9149798925606861 1.2012790518517402 1.038420275293639 0.8848675204191103 0.9389835433426532 1.140573815379151 0.9990058655784463 0.9266227441779354 0.9294077260238678 1.0 13.431691845263893 -5.5327895506152585 24.88355145732932 0.9764175830813573 1.0735595300537055 0.1279187007199878 0.09162182115549418 329.5847519680534 827502.0579159387 0.025107520904808774 0.043552796643183476 2.9323138346773734e-06 5.5327895506152585 0.09714194697234824 LIS(ph)WYDNEFGYSNR ddPTM_A459_Selumetinib_30min_R1 1 LISWYDNEFGYSNR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 LIS(1)WYDNEFGYSNR 141.06 0.00055737 12783000.0 1614.2 3646.3 3043.5 3897.6 3482.4 3151.4 3469.5 3719.6 1339.2 2499.8 True False 1651.8077193135653 3219.3895008811196 2630.2094167488253 3216.9573270133374 3167.4175348676567 3119.699777242262 3207.7928216895257 3620.944125036415 2272.5245887019387 2820.673680114 0.5856075202739531 1.141354820154526 0.9324756122241418 1.1404925531418868 1.1229294466773068 1.1060122974296611 1.1372435047360316 1.2837160677480677 0.8056673144162115 1.0 11.461824056820177 -4.757532483078748 24.99958319421029 1.0853920275091773 0.5856068014841259 0.5737821196943815 0.12607313281033158 77.99860388306165 499030.30101243587 0.029704406146853914 0.21907108605962203 1.747702538025726e-05 4.757532483078748 -0.4997852260250514 LISDS(ph)VER ddPTM_A459_Selumetinib_30min_R1 1 LISDSVER 8 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 LIS(0.002)DS(0.998)VER 96.665 0.020894 9162600.0 2635.0 3595.1 2818.0 2453.0 2909.2 2694.4 2957.2 2641.0 1491.5 2681.0 True False 2696.3903731825344 3174.1840206833535 2435.331078165988 2024.629598512856 2646.063373660977 2667.2967823194604 2734.1360231446197 2570.9521008229867 2530.9665651500472 3025.132465151464 0.8913296869621641 1.0492710839108417 0.8050328725172219 0.6692697334202473 0.8746933908325539 0.8817123921169887 0.9038070413910703 0.8498643052625012 0.8366465251707004 1.0 11.56278260147343 -9.51759690271443 14.952146691503668 0.9999999999996808 0.8623097621824792 0.1766733890030988 0.08911067179153584 0.0 0.0 0.09290982230296987 0.022533941824265432 3.0367084454752563e-10 9.51759690271443 -0.13769023781720158 LISDS(ph)VER ddPTM_A459_Selumetinib_30min_R2 2 LISDSVER 8 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 LIS(0.331)DS(0.669)VER;LIS(0.007)DS(0.993)VER 99.53 0.018576 28056000.0 31055.0 23952.0 31704.0 34182.0 38487.0 34315.0 32694.0 32292.0 27778.0 30889.0 True False 29329.087423014837 25789.041382181254 29664.199156705236 29526.352632761038 33651.9189818545 39041.579769444535 34214.335781931986 32385.964373771603 33334.37618216858 29997.15431073971 0.9777289911968187 0.8597162622505213 0.988900442002418 0.9843051219758499 1.1218370460496079 1.3015094486968286 1.1405860511802757 1.079634555941083 1.1112512819335687 1.0 14.872538025053588 -6.163989930977459 2.8429288147481198 1.140388630541134 0.9380016115756166 0.544239157427137 0.07779920955024813 0.2032403271247416 3.1898116826303435 0.02534738711240218 0.03394880000641083 6.855041195314484e-07 6.163989930977459 -0.20238701896551736 LISWYDNEFGYS(ph)NR ddPTM_A459_Selumetinib_30min_R1 2 LISWYDNEFGYSNR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 LISWYDNEFGYS(1)NR;LISWYDNEFGYS(1)NR 195.6 7.3881e-05 25032000.0 2531.0 5979.9 4465.6 4725.9 4804.3 4364.0 4889.9 5533.3 1680.1599999999999 3265.5 True False 2589.967375531307 5279.7705280199125 3859.1960477849693 3900.6102811300107 4369.7519132680545 4320.102122194968 4521.050906118926 5386.538909308531 2851.1088059688245 3684.6587336636 0.7029056319026163 1.432906249847002 1.0473686511390512 1.0586082899600564 1.185931243332073 1.172456510755219 1.2269931173853146 1.461882713885087 0.7737782552073719 1.0 11.847315290400232 -4.737987093306681 24.804563400051077 1.163531715866737 0.7029034846441581 0.3269347507479673 0.19218166967481037 2116.805824375204 2238735.2278123214 0.045013206352108516 2.6212088845566113 1.8281545458209585e-05 4.737987093306681 -0.460628231222579 LISWYDNEFGYSNR ddPTM_A459_Selumetinib_30min_R1 2 LISWYDNEFGYSNR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 421.96 0.0 357980000.0 3453.7 3916.7 4657.5 4081.5 3868.6 3475.2 3959.7 4008.1 2313.8 3039.4 False True 3534.1644902696457 3458.1309431755694 4025.0370818162155 3368.7426442438755 3518.6858130568025 3440.24264322914 3661.016641027239 3901.7921678563457 3926.3496067342767 3429.536596263098 1.03050788089579 1.0083376707347658 1.1736387610506878 0.9822734208214996 1.0259945372476396 1.0031217182454641 1.0674960124398052 1.1377024441459025 1.1448630147328118 1.0 11.743797935276255 -7.537120676787126 8.819294863238035 1.105441972025031 1.0388390629584467 0.14157812218079524 0.06125709137399424 0.31323311784852814 155.57645293417 0.02812296473963964 0.01654527949632465 2.903215829939775e-08 7.537120676787126 -0.06660290906658428 LISWYDNEFGYSNR ddPTM_A459_Selumetinib_30min_R2 2 LISWYDNEFGYSNR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 164.13 0.0036414 3383300.0 58852.0 63035.0 63971.0 63073.0 51226.0 40069.9 38388.1 38568.0 27939.8 52444.0 False True 55581.24144322229 67869.58181052921 59855.17550635851 54482.34859300618 44790.531913749546 45589.16500666373 40173.22271457709 38680.226494723895 33528.5407032383 50929.805454123925 1.0913303309844418 1.3326102702603908 1.1752484615374055 1.0697537150830525 0.8794561753057459 0.8951372305501758 0.7887959193318331 0.7594811358461974 0.6583284660971231 1.0 15.636222585869783 -6.200382555350443 1.3008444152073282 0.7927734876556671 1.2273692637092353 0.7431922104750825 0.09969586140015128 0.20337567549879443 0.6982606168960052 0.03762545687704742 0.05685873187094869 6.304018001680715e-07 6.200382555350443 0.43459577605356814 LITNSYRS(ph)PGGY(ph)K ddPTM_A459_Selumetinib_30min_R2 1 LITNSYRSPGGYK 13 1 H3BM22;Q6IMN6-4;Q6IMN6-10;Q6IMN6-7;Q6IMN6-3;Q6IMN6-2;Q6IMN6-9;Q6IMN6 H3BM22 CAPRIN2 Caprin-2 2 LIT(0.014)NS(0.198)Y(0.008)RS(0.78)PGGY(1)K 104.55 0.045297 0.0 31199.0 24471.0 28525.0 29463.0 31841.0 24427.0 23491.0 25691.0 22596.0 29732.0 True False 29465.08447949249 26347.847013333234 26689.732555671726 25450.08857349008 27840.848917848358 27791.597523771565 24583.378046533435 25765.756556626005 27115.83138499106 28873.559906986735 1.0204867212221593 0.912525060928066 0.9243658434100267 0.8814323088484751 0.9642333334557585 0.9625275723983948 0.851414862792337 0.8923650786265287 0.939123248824945 1.0 14.817461372247523 -4.758605477948455 24.945466745590608 0.9206343998221554 1.0204868591690448 0.3123431910858083 0.04183734014588409 89.52826289755038 787922.208876887 0.010291382893179032 0.06968179470782483 1.7433898855390266e-05 4.758605477948455 0.09985245934688936 LITPPPPPPS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 LITPPPPPPSPER 13 0 Q96HE9;J3QKY4;J3QR53 Q96HE9 PRR11 Proline-rich protein 11 1 LIT(0.227)PPPPPPS(0.773)PER;LITPPPPPPS(1)PER 120.29 0.0030642 15554100.0 3825.5 4408.6 3496.0 3404.4 3831.2 3557.2 3996.7 4043.4 2209.7 3227.6 True False 3914.6267068727834 3892.439062497464 3021.2624021534075 2809.885448502721 3484.668636453297 3521.417797679183 3695.225701238368 3936.155897185786 3749.699509897457 3641.8938994863356 1.074887631247279 1.0687952944061512 0.8295855084025199 0.7715451152761579 0.9568287085312359 0.9669193817469134 1.0146439745978197 1.0807991681858042 1.0296015242031973 1.0 11.830473177071674 -7.186014560429402 2.2696552586623393 1.0416117738613997 0.9332295761908856 0.18803055076019082 0.0891541432430981 0.5528042022487625 5.574323223142231 0.04683276467068428 0.03240491371494438 6.516065475245065e-08 7.186014560429402 -0.10838219767051405 LITPPPPPPS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 LITPPPPPPSPER 13 0 Q96HE9;J3QKY4;J3QR53 Q96HE9 PRR11 Proline-rich protein 11 1 LITPPPPPPS(1)PER;LIT(0.099)PPPPPPS(0.901)PER 115.12 0.0040667 13990700.0 31242.0 25284.0 27361.0 31554.0 29144.0 26155.0 30965.0 34234.0 25192.0 24369.0 True False 29505.694711635133 27223.201499126197 25600.623048404337 27256.29076631391 25482.670169334266 29757.613838549387 32404.93385598348 34333.615272256204 30231.10392329149 23665.403651734145 1.2467860318737063 1.1503375095455575 1.0817741976916748 1.1517357222139175 1.0767900072334897 1.2574310701169393 1.3692956322597492 1.4507935625150563 1.2774387611629108 1.0 14.53049190933283 -6.933651925922779 5.484647466605683 1.312338452957435 1.1400213147117033 0.2052287513022113 0.11847458444156074 0.2375645987909312 13.555042648469156 0.04091121512734064 0.03581266020896745 1.1650594157012101e-07 6.933651925922779 -0.17231713824573158 LITSEEERS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 LITSEEERSPAK 12 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LITSEEERS(1)PAK;LIT(0.001)S(0.011)EEERS(0.988)PAK 120.84 0.018674 58752000.0 6524.2 9333.7 7184.4 7201.9 6486.3 7029.9 7070.299999999999 7329.700000000001 4135.4 7875.599999999999 True False 6676.201166116695 8240.906064880592 6208.797941084363 5944.223361406341 5899.615310249279 6959.185588638503 6536.981578668811 7135.29254577896 7017.4717623342285 8886.509974840312 0.7512736929366542 0.9273501169989604 0.6986767537157841 0.6689041455234688 0.6638843963437169 0.7831179628832361 0.7356072965851005 0.8029352992322702 0.7896769127815366 1.0 13.117401221087833 -9.092877228902912 0.9041102214467973 1.0011409255273698 0.747893336191001 0.5187228266320073 0.071401479368718 1.8379520772434976 2.141226414285458 0.0789689181726856 0.024732400379878765 8.074632605022278e-10 9.092877228902912 -0.2532475893363688 LITSEEERS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 LITSEEERSPAK 12 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LITSEEERS(0.999)PAK;LITSEEERS(1)PAK 82.20200000000001 0.020229 81977000.0 202570.0 152052.0 180562.0 191690.0 170402.0 133264.0 203686.0 189647.0 133384.0 161975.0 True False 191311.9703519597 163713.89947576128 168944.8375010408 165581.49131630606 148994.57734679178 151619.90634985451 213157.802596152 190198.84137224904 160064.52706034898 157298.36088840867 1.2162362612772621 1.0407857942773093 1.0740406737034878 1.0526587205430171 0.9472099804809294 0.9639001035580873 1.3551177608733722 1.209159715956486 1.0175854735950027 1.0 17.263144111811613 -7.200510500805706 24.999962957727213 1.1629001163518744 1.0454177594509881 0.13610650649753842 0.11537008606809396 406.7429202223239 166891.9741874685 0.04462641500601155 0.03456746739722203 6.302161078121897e-08 7.200510500805706 -0.11748235690088626 LIVENLSS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 LIVENLSSR 9 0 Q13247-3;Q13247;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;A0A0D9SEM4;B4DJK0;B4DUA4;Q13243-3;Q13243;Q08170 Q13247-3;Q08170 SRSF6;SRSF4;SRSF5 Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 5;Serine/arginine-rich splicing factor 4 1 LIVENLS(0.018)S(0.982)R;LIVENLS(0.019)S(0.981)R 107.11 0.012777 37367000.0 6562.200000000001 13002.0 10731.6 11704.4 7644.2 10213.9 8577.9 7600.400000000001 5221.8 6233.799999999999 True False 6715.086492181563 11479.719795534189 9274.30766445924 9660.446258798975 6952.783459693126 10111.157439479199 7930.862096893093 7398.8127024214355 8861.013214817644 7033.968952354047 0.9546653585859567 1.6320401573129335 1.3185027865889887 1.3733990474276871 0.9884580820286745 1.4374754150848665 1.1275088290287212 1.0518688314575637 1.259745852567652 1.0 12.780123251643547 -7.668901737763797 0.42078649534235446 1.019204685998338 1.3398798882302583 0.13883601108005372 0.19920578797884628 1.8868474056671924 0.8598503307851991 0.21822094925492896 0.1888901999478471 2.1433755003161607e-08 7.668901737763797 0.32067520223192036 LIVENLSS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 LIVENLSSR 9 0 Q13247-3;Q13247;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;A0A0D9SEM4;B4DJK0;B4DUA4;Q13243-3;Q13243;Q08170 Q13247-3;Q08170 SRSF6;SRSF4;SRSF5 Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 5;Serine/arginine-rich splicing factor 4 1 LIVENLS(0.011)S(0.989)R;LIVENLS(0.066)S(0.934)R 103.21 0.01544 31368000.0 91005.0 104912.0 125548.0 97927.0 107016.0 77721.0 44921.0 59316.0 45454.0 107802.0 True False 85947.30642187932 112958.41305475104 117470.37836632661 84589.17366650268 93571.69334482148 88426.36226900762 47009.91550927281 59488.59973970759 54546.07009087373 104689.47615676677 0.8209736983799395 1.0789853689362432 1.1220839255172232 0.8080007348573892 0.8938022882520014 0.8446537848426519 0.44904146276248463 0.5682385844650389 0.521027252148955 1.0 16.675756897989835 -7.0583718070448835 4.113544928639306 0.5993026043367179 0.949847042597658 0.42846464732466305 0.16673825422664398 0.19293111248153863 6.575339632187481 0.0640562322934593 0.0503494080597495 8.742350069910798e-08 7.0583718070448835 0.35054443826094006 LKATVT(ph)PS(ph)PVKGK ddPTM_A459_Selumetinib_30min_R1 1 LKATVTPSPVKGK 13 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 2 LKAT(0.308)VT(0.953)PS(0.739)PVKGK 87.148 0.045079 0.0 2576.9 2656.5 4669.6 5353.8 3153.5 2638.6 2855.0 2944.5 1991.8 2588.6 True False 2636.936756225453 2345.4757450266547 4035.4939682767586 4418.859333272784 2868.266481795646 2612.058079657114 2639.6450514263133 2866.402294916047 3379.9391246837813 2920.872025099248 0.9027909246163748 0.8030053096718465 1.3816058812572034 1.5128561933906148 0.9819897815270375 0.8942733735718391 0.9037181460685945 0.9813515519628595 1.1571678237320018 1.0 11.512183434065307 -6.46406762205376 24.999983097619065 0.9761565909498513 1.1550144957635577 0.13361961862002214 0.20303553527832338 571.3347883069126 242867.88744896714 0.07006634568874352 0.07944766496797097 3.4350445819092943e-07 6.46406762205376 0.17885790481370645 LKATVT(ph)PSPVKGK ddPTM_A459_Selumetinib_30min_R2 1 LKATVTPSPVKGK 13 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 LKAT(0.019)VT(0.893)PS(0.088)PVKGK 97.129 0.044256 149920000.0 88025.0 125040.0 104130.0 112720.0 101460.0 55464.0 49447.0 47575.0 28473.0 96468.0 True False 83132.9228919942 134630.16593303063 97430.38916817159 97367.34154715421 88713.68773609161 63103.66254793741 51746.38347737167 47713.43537353478 34168.39560209108 93682.7181860352 0.8873880316635219 1.4370864609807965 1.0400038668251945 1.0393308758804594 0.9469589424158671 0.6735891503769791 0.5523578358882977 0.5093088276835159 0.36472463933251226 1.0 16.51549531551477 -6.631703642439033 1.4948459636883835 0.559590798760569 1.1390214276685986 0.5646938099596777 0.20022355236305864 0.25528404823804873 1.1815877263089805 0.08128937067207517 0.08210009220448723 2.335050930648503e-07 6.631703642439033 0.5794306289080295 LKATVTPS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 LKATVTPSPVK 11 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 LKATVT(0.001)PS(0.999)PVK 80.102 0.02443 890420000.0 18052.0 21982.0 24744.0 27089.0 21679.0 20808.0 23012.0 20771.0 11754.0 16984.0 True False 18472.57647692261 19408.337220845442 21383.900709062906 22358.41467350786 19718.138277738326 20598.690412152355 21276.186312932507 20220.085606283308 19945.679521806003 19164.061838169524 0.9639175991454138 1.0127465348806894 1.1158334224570323 1.1666845401727972 1.0289122652727636 1.0748603602982247 1.1102127770510641 1.0551043811604948 1.040785595988827 1.0 14.226115753396247 -2.803262043966467 15.085054003924338 1.0630966467403569 1.0198244487228634 0.0 0.05826917639536824 0.0 0.0 0.013867616804267747 0.0 0.0015730334434567335 2.803262043966467 -0.04327219801749349 LKATVTPS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 LKATVTPSPVK 11 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 LKATVT(0.003)PS(0.997)PVK 63.29 0.047847 66304000.0 29818.0 491230.0 0.0 156930.0 35368.0 28359.0 26257.0 27940.0 31166.0 102410.0 True False 28160.834930911496 528905.7614465982 0.0 135555.86328065005 30924.75564606828 32265.19483262938 27478.002527258443 28021.300774284 37400.07085079799 99453.15720686497 0.2831567717084766 5.318139476924412 0.0 1.3630121666091564 0.31094795293169064 0.324426048793172 0.2762909021591294 0.281753757862096 0.3760571499304435 1.0 16.601729550652585 -5.308949117504008 24.99978540251855 0.4769243881653239 2.8006589164229463 0.3768957939388117 1.187479498517795 318.65414441549973 167676.30110784818 0.2811882497640599 0.5853422323338154 4.909653949155669e-06 5.308949117504008 2.3237345282576225 LKATVTPS(ph)PVKGK ddPTM_A459_Selumetinib_30min_R1 1 LKATVTPSPVKGK 13 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 LKATVT(0.014)PS(0.986)PVKGK 143.97 0.022666 65403000.0 1648.0 1453.7 4858.9 4001.4 2452.1 2328.4 2308.1 2067.4 1493.7 1666.8 True False 1686.3951935502146 1283.5001281932048 4199.088068027227 3302.630605580656 2230.307987953417 2304.9784100180505 2133.9981587380294 2012.565836138371 2534.699804468402 1880.750016006886 0.8966610018330262 0.6824405781041905 2.2326667724520455 1.7560178532352935 1.1858609432255622 1.2255634137448341 1.1346527399047042 1.0700868371711354 1.3477069163343405 1.0 10.877092387306055 -6.481618851584391 24.450173652911563 1.1638993360507837 1.4100216051969854 0.07119675149167892 0.40785764191554286 1218.954190153996 722339.0409247937 0.13812821779149745 0.15660190636104188 3.298991134228085e-07 6.481618851584391 0.24612226914620172 LKDDEVAQLK ddPTM_A459_Selumetinib_30min_R2 1 LKDDEVAQLK 10 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 135.8 0.0054273 14683000.0 135080.0 93099.0 130540.0 133440.0 129260.0 109110.0 140470.0 142160.0 102870.0 120530.0 False True 127572.79436808394 100239.39393953285 122141.19852120546 115265.24180316027 113021.2032009384 124138.91209803578 147002.13333602465 142573.66206414517 123446.87442795334 117049.98572545082 1.0899001275174447 0.8563810864074052 1.0434960565283318 0.9847522926959017 0.965580666246622 1.0605632399581197 1.2558919373200843 1.218057919277 1.0546509139907705 1.0 16.836765232946348 -7.005631564915119 5.656494666645335 1.151981715713759 0.9855663858732746 0.3601241707900176 0.08896379977106214 0.15359962296511231 17.61529569053046 0.03190171153837477 0.026388701869602686 9.871165539385831e-08 7.005631564915119 -0.16641532984048446 LKDLEALLNSK ddPTM_A459_Selumetinib_30min_R1 1 LKDLEALLNSK 11 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 117.07 0.0060573 0.0 4158.0 4612.8 5895.3 6549.0 5026.0 4626.5 5593.5 4948.9 2904.1 3755.5 False True 4254.873309940408 4072.731231567459 5094.750640564921 5405.340089955445 4571.399187412369 4579.961610525897 5171.577791647311 4817.639095707257 4928.045592928091 4237.555006667782 1.0040868621753287 0.9611040388051663 1.2022854293450689 1.2755799231986737 1.0787822648247123 1.080802869418648 1.2204154951404396 1.1368912233886554 1.1629455157924375 1.0 12.049016380304995 -5.255555288084552 24.977808393542485 1.152342141478596 0.9825954330746659 0.42042425468792965 0.0757151542622002 416.4481810441089 1767797.3197677287 0.019280953264817192 0.0482164528761765 5.551939333684381e-06 5.255555288084552 -0.16974670840393002 LKDLFDYS(ph)PPLHK ddPTM_A459_Selumetinib_30min_R1 4 LKDLFDYSPPLHK 13 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 LKDLFDYS(1)PPLHK;LKDLFDYS(1)PPLHK;LKDLFDY(0.019)S(0.981)PPLHK;LKDLFDY(0.002)S(0.998)PPLHK 134.85 0.0016099 1653700200.0 22903.5 30430.6 29873.9 31977.699999999997 27556.2 26359.5 26704.2 25567.7 15271.2 22484.6 True False 23437.10698754693 26867.771205197874 25817.18846558656 26393.39499077236 25063.74657544224 26094.34736251106 24689.880694325242 24889.56154040586 25914.1110356818 25370.71742855078 0.9237857405314099 1.0590071518814204 1.017597887733886 1.0403093670922652 0.9879005844445262 1.0285222495579076 0.9731644666279968 0.9810349908511671 1.0214181411566832 1.0 14.630876695797106 LKDLFDYS(ph)PPLHK ddPTM_A459_Selumetinib_30min_R2 1 LKDLFDYSPPLHK 13 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 LKDLFDYS(1)PPLHK 124.45 0.0012409 973460000.0 3822900.0 3443600.0 3716100.0 4045800.0 3576300.0 2879800.0 2985800.0 3240200.0 2291400.0 3474100.0 True False 3610438.5222812234 3707713.047080804 3477010.1717837625 3494755.0606057155 3127013.221472349 3276466.3097784203 3124645.61625046 3249628.4455560166 2749744.0270653395 3373793.706204185 1.0701420527407661 1.0989744394455903 1.0305935912411508 1.0358532159743765 0.9268537124015548 0.9711519420269278 0.9261519489186438 0.9631971390485919 0.8150302794177193 1.0 21.685940330698585 -6.026553197088831 1.0054126229638072 0.924518747608191 1.0901148637792315 0.6200517816313986 0.048345351040446946 0.35901882819217573 0.7407289883519095 0.019531019105447592 0.040326051467141265 9.406905970131326e-07 6.026553197088831 0.16559611617104053 LKDLGHPVEEEDELES(ph)GDQEDEDDESEDPGKDLDHI ddPTM_A459_Selumetinib_30min_R1 1 LKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI 36 2 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 1 LKDLGHPVEEEDELES(0.972)GDQEDEDDES(0.028)EDPGKDLDHI 63.657 3.3751e-05 6392400.0 1973.3 2182.8 2449.6 2547.5 2059.1 1869.9 1925.6 1700.9 1000.6 1840.5 True False 2019.2740506266002 1927.2367612438104 2116.9577746896393 2102.6269474975547 1872.8547685636324 1851.0905037333591 1780.350441690546 1655.7866066981512 1697.9451190674724 2076.746102988166 0.9723259129852845 0.9280078862171782 1.0193628251636606 1.01246220925714 0.9018217325020326 0.8913417490322394 0.8572788166684673 0.7972985259563944 0.8175987987286224 1.0 11.02010913187493 -6.564878033951022 2.2483316912993354 0.8563255711420813 0.9810806174044074 0.44116822023054947 0.057054847182489904 0.261207602228737 2.6723073609246044 0.02069053902027232 0.021659724934668015 2.723466051285815e-07 6.564878033951022 0.12475504626232614 LKDPANFQYPAESVLAYK ddPTM_A459_Selumetinib_30min_R1 2 LKDPANFQYPAESVLAYK 18 1 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2;H3BRK3 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 ; 117.26 0.0028828000000000005 34926000.0 6120.799999999999 7870.2 7396.2 8729.5 7572.299999999999 6700.7 7423.599999999999 6888.3 4825.299999999999 5936.799999999999 False True 6263.402730996449 6948.753325243282 6391.836664418484 7205.056698009776 6887.38680199815 6633.297041748817 6863.631875225355 6705.599907648227 8188.181674031859 6698.84610932906 0.9349972560608316 1.0373060093985726 0.9541698017986974 1.0755668335141702 1.0281452491357461 0.9902148718584598 1.0245991269551347 1.0010082032351455 1.2223271799942823 1.0 12.709696894304795 -8.154498073534066 24.985599658104167 1.111403953018735 1.0082666517636192 0.31019582424549996 0.06278769168976736 28.52186934174807 6642.438145301261 0.0387459678945238 0.014644599034919513 7.006512908437668e-09 8.154498073534066 -0.10313730125511578 LKDPANFQYPAESVLAYK ddPTM_A459_Selumetinib_30min_R2 1 LKDPANFQYPAESVLAYK 18 1 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2;H3BRK3 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 79.565 0.033794 6049300.0 30410.0 22923.0 32881.0 36041.0 32960.0 23906.0 25886.0 19950.0 20440.0 27744.0 False True 28719.93394087525 24681.120390937747 30765.472258125923 31132.153625807186 28819.27013386141 27198.834502938687 27089.75029213589 20008.051197099703 24528.571141317792 26942.95863243103 1.0659532359710966 0.9160508586918615 1.141874308528751 1.155483852034485 1.0696401433498057 1.0094969477553835 1.005448238321094 0.7426077985739906 0.9103889248374134 1.0 14.717620662790967 -7.575027971597112 7.651301066762478 0.8694111198606238 1.057395017656368 0.45083905597241314 0.08607801343973928 0.20453599887131868 25.510929118843677 0.041507953556293276 0.02389015239867073 2.6605536960449194e-08 7.575027971597112 0.1879838977957442 LKDVLLQVDDERR ddPTM_A459_Selumetinib_30min_R1 1 LKDVLLQVDDERR 13 2 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 99.732 0.0072961 9926400.0 3990.8 3868.4 5907.8 5132.8 5046.5 4519.1 4174.3 4094.5 2652.2 2971.5 False True 4083.777875254973 3415.4859296296313 5105.55320922251 4236.45283458899 4590.044966031941 4473.641957014502 3859.4291902517894 3985.900559189594 4500.589690976167 3352.9209698610875 1.2179761801615518 1.0186598372973688 1.5227180285833086 1.2635110915735386 1.3689690294794237 1.3342521333569775 1.1510647656009878 1.1887845240070574 1.3422892252550251 1.0 11.711202763101511 -7.264968605064892 24.858783814405378 1.1862666722650157 1.2887325856622154 0.1364551746496131 0.14217060701579576 722.3129270872435 5087704.801847784 0.05851082437740579 0.04125070236627421 5.43289604211959e-08 7.264968605064892 0.10246591339719968 LKDYAFVHFEDR ddPTM_A459_Selumetinib_30min_R1 1 LKDYAFVHFEDR 12 1 O43390;B4DT28;O43390-4;O43390-3;O43390-2 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 79.88600000000002 0.032807 8977300.0 4125.7 5244.2 6115.7 6102.6 5058.6 4909.4 3734.0 4213.5 2955.0 3410.0 False True 4221.820782785268 4630.206626037563 5285.221531135466 5036.895469989631 4601.050523168366 4860.015893378546 3452.3413737393535 4101.744292623118 5014.419175339181 3847.7067162127923 1.0972304009024647 1.2033678675475992 1.3736030110781379 1.3090642924436116 1.1957903401995962 1.263094162790595 0.8972464972947346 1.0660231132845719 1.303222814309183 1.0 11.909783121402404 -7.208897469043322 24.99962892261048 1.0721246849941977 1.2458307906197053 0.3461974420356364 0.11672164516594323 396.04633908116267 188440.2630331177 0.045963564456428185 0.03560319342631208 6.181623225387157e-08 7.208897469043322 0.1737061056255076 LKEDILENEDEQNS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 4 LKEDILENEDEQNSPPK 17 1 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 LKEDILENEDEQNS(1)PPK;LKEDILENEDEQNS(1)PPK;LKEDILENEDEQNS(1)PPK;LKEDILENEDEQNS(1)PPK 167.73 7.0265e-07 121810000.0 19707.0 30331.3 26389.300000000003 27872.800000000003 17975.699999999997 24487.700000000004 23050.0 24515.8 14120.0 22817.800000000003 True False 20166.1347568532 26780.097295361185 22805.778006048877 23005.338717256083 16349.801108867594 24241.375971052657 21311.319942338527 23865.56134545859 23960.608716003113 25746.686894193626 0.7832516408703852 1.040137607041029 0.885775249443532 0.893526177243575 0.635025437488611 0.9415338008603955 0.8277305748082344 0.9269371800548339 0.9306288150576256 1.0 14.652099176550623 -8.318846075899607 1.3945453154427476 0.9948937119693757 0.8622549772306182 0.16662173001865632 0.10021139977200216 0.7785239941109215 3.0465643664138313 0.09561428896873081 0.029445095090351005 4.799035075020283e-09 8.318846075899607 -0.13263873473875754 LKEDILENEDEQNS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 4 LKEDILENEDEQNSPPK 17 1 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 LKEDILENEDEQNS(1)PPK;LKEDILENEDEQNS(1)PPK;LKEDILENEDEQNS(1)PPK;LKEDILENEDEQNS(1)PPK 121.46 0.00078458 82593100.0 645915.0 492997.0 535631.0 498506.0 455687.0 381191.0 518104.0 479879.0 356618.0 493634.0 True False 610017.6301026127 530808.2846647957 501169.08461093676 430608.6228291844 398439.52516653267 433696.600142629 542196.8626035996 481275.3684417554 427951.5647394548 479381.50380483916 1.2725097344409781 1.1072773572859684 1.0454493563751837 0.8982587342470546 0.8311533131840256 0.9047003205179796 1.1310341727834645 1.0039506418622428 0.8927160546304224 1.0 18.87081472033705 -4.975859239184404 1.5649960468376205 0.9549150632419504 1.3189553792937951 0.6055898906516889 0.08035618384709374 0.551551365375271 1.70602545078937 0.02561038688795488 0.2771632272648463 1.0571600938208201e-05 4.975859239184404 0.3640403160518447 LKEDILENEDEQNS(ph)PPKK ddPTM_A459_Selumetinib_30min_R1 2 LKEDILENEDEQNSPPKK 18 2 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 LKEDILENEDEQNS(1)PPKK;LKEDILENEDEQNS(1)PPKK 96.666 0.0041856 45301000.0 4158.6 5987.4 5676.6 6745.6 3964.1 4989.9 5022.6 4576.9 2794.6 4241.8 True False 4255.487288773012 5286.392424533256 4905.7488993318175 5567.607590594509 3605.5478549186973 4939.706136466702 4643.741238281541 4455.505744133558 4742.232090491667 4786.276348630916 0.8891018777029595 1.1044895947233375 1.0249614819535182 1.1632440722289443 0.7533095860522223 1.0320561907963535 0.9702200416425713 0.9308918707562776 0.9907978029409339 1.0 12.224687981849724 -6.223337528580996 24.999878471805623 0.9482494651301968 1.0482029575086451 0.2030400309911673 0.09620479178003505 902.0531343333569 591866.5901165954 0.027206423831957132 0.03512272458571881 5.979466972625454e-07 6.223337528580996 0.0999534923784483 LKEDILENEDEQNS(ph)PPKK ddPTM_A459_Selumetinib_30min_R2 1 LKEDILENEDEQNSPPKK 18 2 Q9NTI5-2;Q9NTI5;A9IYQ1;Q9NTI5-5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 LKEDILENEDEQNS(1)PPKK 49.425 0.039022 10366000.0 36846.0 29496.0 34245.0 33010.0 31427.0 29787.0 31900.0 31560.0 20886.0 29186.0 True False 34798.24682622458 31758.248355411593 32041.713983136826 28513.981054573793 27478.859299055308 33889.88887053606 33383.41320865083 31651.834374960756 25063.783603599015 28343.324345665078 1.2277404866781882 1.1204842441239184 1.1304853866952058 1.0060210547932715 0.9695002238951556 1.195692095155355 1.177822784706502 1.1167297804924456 0.8842923045275157 1.0 14.79072135924982 -4.729289748089 1.3574505600193536 1.0658096284391967 1.3055104470773875 0.24302739430248999 0.0923310070160446 2.455340915571193 3.7058275559315508 0.028494459923969293 0.8428174025231885 1.865134914270779e-05 4.729289748089 0.23970081863819082 LKEPGPPLASSQGGS(ph)PAPSPAGCGGK ddPTM_A459_Selumetinib_30min_R2 2 LKEPGPPLASSQGGSPAPSPAGCGGK 26 1 J3QQY0;J3KSZ8;Q68DK7 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 LKEPGPPLASSQGGS(1)PAPSPAGCGGK;LKEPGPPLASSQGGS(1)PAPSPAGCGGK 148.27 7.3693e-12 0.0 24157.0 24205.0 26354.0 29942.0 29341.0 19182.1 20893.5 23586.8 21136.1 28043.0 True False 22814.45064813296 26061.445668658038 24658.41233206564 25863.84794716901 25654.921268131922 21824.26015723334 21865.089149684816 23655.43368299507 25363.910591976863 27233.32572553576 0.8377401599078524 0.9569688965391806 0.9054499101791409 0.9497131642250128 0.9420414358014372 0.8013806458007983 0.8028798748286063 0.8686208185294892 0.9313556062744841 1.0 14.733085554173547 -4.679051878956917 21.872527726095516 0.8982911187356537 0.8377193451844052 0.08582641425986715 0.06234250267697486 83070.17801364214 22028990.377598263 0.016466345232826588 281.30959725118777 2.0938623170952654e-05 4.679051878956917 -0.06057177355124854 LKETCVSGEDPTQGADLS(ph)PDEK ddPTM_A459_Selumetinib_30min_R1 4 LKETCVSGEDPTQGADLSPDEK 22 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 LKETCVSGEDPTQGADLS(1)PDEK;LKETCVSGEDPTQGADLS(1)PDEK;LKETCVSGEDPT(0.003)QGADLS(0.997)PDEK;LKETCVSGEDPTQGADLS(1)PDEK 199.8 1.2352e-22 76028000.0 13036.9 15010.900000000001 15388.8 16018.1 13058.900000000001 13772.1 13026.9 13443.2 7586.9 12545.099999999999 True False 13340.634404608492 13253.416849621923 13299.085484627669 13220.839531976686 11877.72480073606 13633.565178066307 12044.270444982636 13086.642666332276 12874.41517474816 14155.385784622022 0.9424423048293993 0.9362808651969082 0.9395071025952108 0.933979457228174 0.8390958029303346 0.9631362497288767 0.8508613349179902 0.9244991881852633 0.9095064854208729 1.0 13.78906344790132 -6.029729981648408 24.975473212331863 0.9078576943777963 0.9387048889769715 0.05185098449088765 0.044522860889212236 1564.5032751765636 1314301.6108985045 0.01218822186729744 0.015761422116751352 9.338347229589549e-07 6.029729981648408 0.030847194599175176 LKETCVSGEDPTQGADLS(ph)PDEK ddPTM_A459_Selumetinib_30min_R2 4 LKETCVSGEDPTQGADLSPDEK 22 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 LKETCVSGEDPTQGADLS(1)PDEK;LKETCVSGEDPTQGADLS(1)PDEK;LKETCVSGEDPTQGADLS(1)PDEK;LKETCVSGEDPTQGADLS(1)PDEK 161.0 1.6682e-09 64690400.0 260120.0 241976.0 254882.0 241781.0 234586.0 175860.0 247017.0 227352.0 158845.0 224817.0 True False 245663.57174286342 260534.78112452806 238483.16961453925 208850.01070451114 205115.20945455154 200083.11870186529 258503.77995489954 228013.55667985024 190618.43850012877 218325.9490652848 1.1252147204426168 1.1933294335371092 1.0923262701275465 0.9565972876731198 0.939490749188119 0.9164422257568455 1.1840268234794233 1.0443722226150434 0.8730910792611701 1.0 17.736124086043375 -5.569730381842489 4.338395517638999 0.9932835457402598 1.1570837339576583 0.42707450660532287 0.08134370875195772 0.20508424978779363 8.291823340721786 0.023736054071749255 0.0441926762564717 2.6932062779877735e-06 5.569730381842489 0.1638001882173985 LKFS(ph)DDEEEEEVVK ddPTM_A459_Selumetinib_30min_R1 5 LKFSDDEEEEEVVK 14 1 Q5JSZ5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK 120.24 0.0021042 79816300.0 22619.27 27796.36 20776.8 22336.14 18441.91 22398.43 22371.17 22484.39 14630.47 24263.93 True False 23146.254981562244 24541.949249022833 17955.424678793162 18435.552450275976 16773.842496683657 22173.122130347256 20683.6946357677 21888.03093760823 24826.839022749446 27378.441766192675 0.8454190044571346 0.896396860661647 0.6558234698720071 0.6733601790676226 0.6126660764673707 0.8098752412464529 0.7554737706551382 0.7994622602896235 0.906802484771285 1.0 14.740752718031354 -8.355361558563613 1.3843180319685926 1.000322666216181 0.7432674824975568 0.5038375494732934 0.08231427844015236 0.3661809980908471 1.4470095036894983 0.08568773593551375 0.026284772962323868 4.412029843888473e-09 8.355361558563613 -0.25705518371862424 LKFS(ph)DDEEEEEVVK ddPTM_A459_Selumetinib_30min_R2 7 LKFSDDEEEEEVVK 14 1 Q5JSZ5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK;LKFS(1)DDEEEEEVVK 114.29 0.0029623 64914400.0 383376.0 308346.0 314364.0 320239.0 290673.0 248092.0 348479.0 310501.0 232930.0 282637.0 True False 362069.4966957245 331995.1467113424 294138.16249364376 276621.8957569125 254156.05909040937 282264.4210450544 364683.96399803826 311404.5065037926 279522.508607982 274476.5354308827 1.3191273204003955 1.2095574807156648 1.0716331799798315 1.0078161884499959 0.9259664353145031 1.028373593400055 1.3286526056791879 1.134539628369103 1.018383987429665 1.0 18.066323295199354 -5.039255520597955 2.562389211206265 1.0700643118449735 1.3198658303928792 0.3968559322082401 0.10264433662443005 0.3789927249891212 4.421775493569768 0.03044379999756376 0.1597266445513734 9.135755738910332e-06 5.039255520597955 0.24980151854790567 LKFS(ph)DDEEEEEVVKDGRPK ddPTM_A459_Selumetinib_30min_R1 1 LKFSDDEEEEEVVKDGRPK 19 3 Q5JSZ5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 LKFS(1)DDEEEEEVVKDGRPK 56.428 0.037848 43804000.0 3178.1 3200.9 6231.5 6409.8 3468.9 3928.2 3208.6 2916.2 2585.4 3033.4 True False 3252.1435464938945 2826.137139941962 5385.296527179335 5290.448756847823 3155.1386074840366 3888.6858745202276 2966.5727187413213 2838.852902847402 4387.234969855131 3422.766437818148 0.9501505888806665 0.8256879899007923 1.573375404081678 1.545664553208671 0.9218094967342523 1.1361236430140647 0.8667178355974448 0.8294030441227058 1.281780410541768 1.0 11.74094713397802 LKGDDLQAIK ddPTM_A459_Selumetinib_30min_R2 1 LKGDDLQAIK 10 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;B2R5W2;G3V2D6;P07910-3;G3V5V7;G3V576;A0A0G2JNQ3;B2RXH8;O60812;A0A0G2JPF8;P0DMR1;B7ZW38 B4DY08;G3V2Q1;A0A0G2JNQ3;O60812 HNRNPC;HNRNPCL2;HNRNPCL1;HNRNPCL4;HNRNPCL3 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3 0 90.913 0.041058 0.0 54145.0 32208.0 42246.0 48867.0 48514.0 45312.0 51934.0 50326.0 42345.0 41841.0 False True 51135.83765960839 34678.25003495716 39527.93835396699 42211.23029972306 42419.23759933718 51553.3166986178 54349.03390526869 50472.44032808217 50815.18321815571 40632.94161402634 1.2584822960973243 0.8534516246538831 0.9728052359448691 1.0388425898545306 1.0439617688101177 1.2687566947115092 1.3375608987784335 1.2421557072466363 1.2505908063671791 1.0 15.310362191530409 -6.717659139783703 5.847021782225936 1.2424451196774167 1.0184416328337946 0.34774826001750736 0.12502579775458117 0.18049985597895093 14.751775393561317 0.04049618751709496 0.039751310851527034 1.915758937011424e-07 6.717659139783703 -0.22400348684362203 LKGSSHS(ph)PDHPGCLMEN ddPTM_A459_Selumetinib_30min_R2 1 LKGSSHSPDHPGCLMEN 17 1 O95149 O95149 SNUPN Snurportin-1 1 LKGS(0.004)S(0.004)HS(0.991)PDHPGCLMEN 58.339 0.037251 10731000.0 39558.0 37760.0 50492.0 69398.0 74920.0 45851.0 44234.0 51249.0 50337.0 63178.0 True False 37359.52472322074 40656.070582463464 47243.399691532926 59945.8726817726 65507.87980670193 52166.55905606301 46290.96864800817 51398.1261052713 60405.80653329324 61353.88698384257 0.608918628628359 0.6626486532657689 0.7700147784275573 0.977050935624653 1.0677054548141882 0.850256790899018 0.7544912135754139 0.8377321899557383 0.9845473449661143 1.0 15.904867126121822 -5.467820363502113 2.886048945935991 0.9128698349826005 0.6342190533938993 0.6320030538838288 0.08853720048499084 0.19378828578572366 3.157820923895162 0.027361007790329323 0.06329948290679185 3.405490212933268e-06 5.467820363502113 -0.27865078158870127 LKLS(ph)PSPSSR ddPTM_A459_Selumetinib_30min_R1 1 LKLSPSPSSR 10 1 Q03252;P20700 Q03252;P20700 LMNB2;LMNB1 Lamin-B2;Lamin-B1 1 LKLS(0.743)PS(0.217)PS(0.032)S(0.008)R 138.2 0.0078913 387990000.0 3124.2 3542.2 3983.3 3613.2 3503.4 2980.1 3378.8 3374.4 1876.3 3029.8 True False 3196.987781365037 3127.477577275897 3442.389738700704 2982.222448164148 3186.5180885755076 2950.122899714304 3123.934395712512 3284.899950404044 3183.944060470017 3418.704342751177 0.935146026342917 0.9148137024212754 1.006928179092102 0.872325345854338 0.9320835524522664 0.8629359558306274 0.9137772917790687 0.9608610810025604 0.9313306274118345 1.0 11.739233945312787 -8.824472221716233 1.0782117427906772 0.99928864281645 0.9216008808798978 0.258259213670455 0.03854436828489349 1.4726910734812688 3.0611824117777653 0.03720788464607526 0.011746803805353668 1.4980550683722987e-09 8.824472221716233 -0.07768776193655225 LKNDMAVPT(ph)PPPPPVPPTK ddPTM_A459_Selumetinib_30min_R2 1 LKNDMAVPTPPPPPVPPTK 19 1 G3V1P5;Q96RN5-3;Q96RN5-2;Q96RN5 G3V1P5 MED15 Mediator of RNA polymerase II transcription subunit 15 1 LKNDMAVPT(1)PPPPPVPPTK 115.26 0.00065894 16822000.0 62045.0 64883.0 63952.0 71045.0 68796.0 53334.0 59424.0 68613.0 54665.0 66979.0 True False 58596.787285814025 69859.31746827262 59837.39794567288 61368.54844053907 60153.2314359566 60680.27438215223 62187.33374642218 68812.65247050638 65599.52746771717 65045.142237658525 0.9008633891784903 1.0740128327035448 0.9199364608511752 0.9434762740054267 0.9247920654269904 0.9328947911350832 0.9560642287352584 1.0579214696630583 1.0085230842917225 1.0 15.989153695811007 -7.712962887217022 10.349836627502599 1.0248616136612996 0.9519032240409875 0.33238443289628306 0.04658288251297345 0.5117634043685295 106.48636298903205 0.021780227549904132 0.012530150220924092 1.93658744861623e-08 7.712962887217022 -0.07295838962031209 LKNDSDLFGLGLEEAGPKESS(ph)EEGKEGK ddPTM_A459_Selumetinib_30min_R1 1 LKNDSDLFGLGLEEAGPKESSEEGKEGK 28 3 Q3YEC7;Q3YEC7-2 Q3YEC7 RABL6 Rab-like protein 6 1 LKNDSDLFGLGLEEAGPKES(0.412)S(0.588)EEGKEGK 87.72 1.7383e-05 14228000.0 1703.8 1828.5 1879.2 2207.6 1586.2 1732.6 1883.1 1779.8 1004.7 1298.1 True False 1743.495224982314 1614.4183699534126 1624.0149617067173 1822.08410178434 1442.7284900663549 1715.1716170749323 1741.0562509074928 1732.5939223948308 1704.9025196153204 1464.7237795647588 1.1903235608698808 1.1021998771899062 1.1087516870855278 1.2439779617190145 0.9849833191723426 1.1709863941613576 1.1886584181932554 1.18288099542541 1.1639754494338383 1.0 10.516412908746554 LKNGFPHPEPDCNPSEAASEES(ph)NSEIEQEIPVEQK ddPTM_A459_Selumetinib_30min_R1 1 LKNGFPHPEPDCNPSEAASEESNSEIEQEIPVEQK 35 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 LKNGFPHPEPDCNPS(0.004)EAAS(0.084)EES(0.456)NS(0.456)EIEQEIPVEQK 63.403 6.685e-05 7603700.0 1026.6 1662.4 1950.5 2479.9 1767.5 1602.0 1582.9 1269.4 778.51 977.89 True False 1050.5177825841329 1467.7654351712076 1685.6328133295829 2046.8320184883953 1607.62993707747 1585.8853344996207 1463.5005785998987 1235.731388407685 1321.0746098792918 1103.411706955228 0.9520632923887934 1.3302065094282742 1.5276553644522632 1.8550029926150198 1.4569629150605894 1.4372562158831341 1.3263413550670997 1.1199186854900987 1.1972635432015546 1.0 10.10775547700362 -7.632150760671791 1.9953103468803939 1.1001513378520942 1.4492415430515257 0.30964621875406806 0.21262530631068643 0.4520878064532822 3.5641277259433073 0.14956624726856602 0.06930004509997095 2.332648167921115e-08 7.632150760671791 0.34909020519943157 LKNGFPHPEPDCNPSEAASEESNS(ph)EIEQEIPVEQK ddPTM_A459_Selumetinib_30min_R1 2 LKNGFPHPEPDCNPSEAASEESNSEIEQEIPVEQK 35 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 LKNGFPHPEPDCNPS(0.05)EAAS(0.084)EES(0.227)NS(0.639)EIEQEIPVEQK;LKNGFPHPEPDCNPSEAAS(0.003)EES(0.18)NS(0.817)EIEQEIPVEQK 93.494 5.2023e-10 27334200.0 1949.44 2978.2 3558.7 4507.1 3226.7 2951.9 2704.2 2348.75 1165.47 2060.5 True False 1994.8581590500783 2629.5109594723835 3075.448086539852 3720.019593745334 2934.8455547201534 2922.206566110753 2500.220016836089 2286.4535201847743 1977.7174674391042 2324.985245969637 0.8580089540388119 1.1309796326796662 1.322781764689106 1.6000185808464762 1.2623071736939877 1.2568710150640308 1.0753702722071985 0.9834271095476165 0.8506365667771347 1.0 11.183005845771369 -7.521339150873652 2.1439992426794685 0.9297462430930381 1.2562523587082965 0.3603783079573891 0.17611376219318614 0.3763116570589681 3.426987953868776 0.11203479785115032 0.0584970357562721 3.010654014724705e-08 7.521339150873652 0.32650611561525844 LKPGGVGAPSSSSPS(ph)PSPSAR ddPTM_A459_Selumetinib_30min_R1 2 LKPGGVGAPSSSSPSPSPSAR 21 1 Q92797 Q92797 SYMPK Symplekin 1 LKPGGVGAPSSS(0.002)S(0.003)PS(0.387)PS(0.387)PS(0.221)AR;LKPGGVGAPSS(0.01)S(0.153)S(0.017)PS(0.74)PS(0.05)PS(0.029)AR 152.52 6.0299e-07 339460000.0 6461.0 10091.400000000001 6701.299999999999 6503.900000000001 6982.5 7229.700000000001 7705.8 8034.1 4036.4 6811.1 True False 6611.528729082483 8909.894196635418 5791.300267606009 5368.115958323592 6350.934107860501 7156.975782042386 7124.545302024827 7821.009569565296 6849.475993008147 7685.371030732242 0.8602745010806009 1.1593316914702694 0.7535485592624965 0.6984849445599417 0.826366623350311 0.931246618207903 0.9270268505626096 1.017648925249108 0.8912355650258759 1.0 12.907899196012892 -6.92557063990838 4.682671980823057 0.9568230753494673 0.8616923273276724 0.1392475561419897 0.1179066164659084 0.5068737786041236 20.906282521605853 0.04650487323168292 0.040547625069792925 1.1869416240639096e-07 6.92557063990838 -0.09513074802179489 LKPGGVGAPSSSSPS(ph)PSPSAR ddPTM_A459_Selumetinib_30min_R2 2 LKPGGVGAPSSSSPSPSPSAR 21 1 Q92797 Q92797 SYMPK Symplekin 1 LKPGGVGAPS(0.001)S(0.009)S(0.114)S(0.073)PS(0.505)PS(0.183)PS(0.114)AR;LKPGGVGAPSSSSPS(0.477)PS(0.261)PS(0.261)AR 178.41 2.047e-14 340530000.0 87250.0 60040.0 92412.0 104139.0 107719.0 83238.0 84154.0 101105.0 91642.0 86781.0 True False 82400.99428942334 64644.87494097208 86466.31253057788 89955.0885502047 94186.37619992162 94703.27894066801 88067.32774798744 101399.1988111661 109972.96069142107 84275.40704588364 0.9777584846853392 0.767066896583202 1.0259969730374772 1.0673942933462044 1.1176021511072853 1.123735645549679 1.0449943920180569 1.203188478887553 1.3049235185722263 1.0 16.362824069918645 -5.616489318848774 2.0797103169826228 1.1339983784651004 0.8720793646092045 0.5222070894406996 0.09411172693152066 0.2424015778238824 2.1022725998815837 0.027782541450989177 0.06294039057337707 2.41830281356619e-06 5.616489318848774 -0.2619190138558959 LKPGGVGAPSSSSPS(ph)PSPSARPGPPPSEEAMDFR ddPTM_A459_Selumetinib_30min_R1 1 LKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFR 34 2 Q92797 Q92797 SYMPK Symplekin 1 LKPGGVGAPS(0.001)S(0.006)S(0.02)S(0.146)PS(0.475)PS(0.146)PS(0.146)ARPGPPPS(0.061)EEAMDFR 59.732 0.00022317 20200000.0 1760.9 1950.1 2247.0 2286.1 1981.3 1815.7 2150.8 1926.0 1209.2 1897.9 True False 1801.925543885057 1721.7813854231051 1941.8697418875022 1886.8755504118405 1802.0917648269258 1797.4357065236948 1988.5634243809861 1874.916223470302 2051.924083526274 2141.5139521115125 0.8414260117746959 0.8040019462518304 0.9067742659219367 0.8810942130689362 0.8415036302005319 0.8393294401614522 0.9285783183529024 0.8755096933277751 0.9581651716548922 1.0 11.064415361179634 -8.293277094132218 0.6751828834016542 1.0025957835783734 0.8508204522070745 0.6865251307910629 0.032369173140885936 0.4197744292574994 0.4390759582608519 0.03256960835802952 0.013952016982470073 5.090060048947948e-09 8.293277094132218 -0.15177533137129895 LKPGGVGAPSSSSPS(ph)PSPSARPGPPPSEEAMDFR ddPTM_A459_Selumetinib_30min_R2 1 LKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFR 34 2 Q92797 Q92797 SYMPK Symplekin 1 LKPGGVGAPS(0.001)S(0.003)S(0.003)S(0.014)PS(0.427)PS(0.427)PS(0.12)ARPGPPPS(0.006)EEAMDFR 70.572 2.5076e-05 4992300.0 20119.0 17091.0 21744.0 26574.0 26299.0 18624.0 12141.0 19305.0 10812.0 19954.0 True False 19000.86652273822 18401.824743773377 20345.014713077155 22954.575357293073 22995.084503956954 21189.2869481607 12705.580556935103 19361.174353885213 12974.702112520938 19377.876173281744 0.9805443255405178 0.9496306292402596 1.049909418924294 1.1845764289144798 1.1866669132535084 1.093478292392875 0.6556745663621065 0.9991380985590382 0.6695626495131848 1.0 14.242122838734952 -7.234487097046687 24.796351613984744 0.8310219953539202 1.077509184875457 0.46384922425095076 0.12797778026746762 598.7315010255586 550839.2381305202 0.04876403937165679 0.03776205281606506 5.827910893486494e-08 7.234487097046687 0.2464871895215368 LKS(ph)EDELRPEVDEHTQK ddPTM_A459_Selumetinib_30min_R1 1 LKSEDELRPEVDEHTQK 17 2 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;H0YCR2;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 LKS(1)EDELRPEVDEHTQK 50.916 0.039122 47384000.0 3331.6 4518.1 4535.0 4129.6 3883.2 4866.3 5627.8 7300.6 4681.4 4841.7 True False 3409.2197978348863 3989.118751592295 3919.17190897188 3408.4428821927013 3531.965245634644 4817.349440246879 5203.290515032225 7106.964372309083 7943.9938840720215 5463.179357151751 0.6240358543916259 0.7301826447213765 0.7173793230568866 0.6238936449579986 0.6465036226590312 0.8817849690291738 0.9524290115463059 1.3008843216918153 1.4540972142297837 1.0 12.415525072410754 -7.396561796425036 1.6408044251477307 1.2843865032811348 0.6778869097030701 0.8027498817183201 0.12237159862869437 0.15258175293209217 0.7976200179107739 0.07202809121161594 0.039031079259116155 4.012713966804911e-08 7.396561796425036 -0.6064995935780647 LKS(ph)EDGVEGDLGETQSR ddPTM_A459_Selumetinib_30min_R1 4 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR 254.59 2.1747999999999996e-30 375924000.0 5350.05 6883.300000000001 9110.4 10317.0 8349.199999999999 9870.8 16823.1 23152.8 15932.599999999999 7414.199999999999 True False 5474.695755614878 6077.400036040644 7873.2577198450745 8515.329624075477 7594.016334170986 9771.508713969322 15554.120022644476 22538.712533106565 27036.458528937044 8365.88479042372 0.6544072614867547 0.7264503621897037 0.9411147675446659 1.0178636016865574 0.9077361838479682 1.168018560948221 1.859231917758299 2.6941217931791543 3.231751238062136 1.0 13.030302414914075 -7.342043847133084 2.2208854749387448 2.4605386369959152 0.8670679469161964 0.5841756864152234 0.5417940552467814 0.19988624998906784 1.9256262105012514 0.26555801440329097 0.16211373660905093 4.549421260758187e-08 7.342043847133084 -1.5934706900797189 LKS(ph)EDGVEGDLGETQSR ddPTM_A459_Selumetinib_30min_R2 8 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(1)EDGVEGDLGETQSR;LKS(0.998)EDGVEGDLGET(0.002)QSR;LKS(1)EDGVEGDLGETQSR 114.58 0.001074 543787000.0 261967.0 243689.0 261310.0 256821.0 216072.0 170139.0 285716.0 347465.0 326732.0 482307.0 True False 247407.92287698985 262379.1627163654 244497.59909281667 221841.53675906424 188927.10365181146 193574.1028819328 299002.3601355133 348476.06562407303 392087.52965484635 468381.54372591915 0.5282187699132835 0.5601825397072023 0.5220051950550133 0.47363424056879216 0.4033615461209657 0.41328294309394425 0.638373488752322 0.7440004207936709 0.8371113996846181 1.0 18.837324702923915 -7.9967395202474725 1.244659684222282 0.9693415725480649 0.4853630469029287 0.9039617737646153 0.05708443293641792 0.14526907126773833 0.4067137345515254 0.05905065098407876 0.020397130625596206 1.007535784250219e-08 7.9967395202474725 -0.48397852564513616 LKS(ph)PQAVLQLGVNNEDSK ddPTM_A459_Selumetinib_30min_R2 2 LKSPQAVLQLGVNNEDSK 18 1 D6RJ90;Q9Y6G5 D6RJ90 COMMD10 COMM domain-containing protein 10 1 LKS(1)PQAVLQLGVNNEDSK;LKS(1)PQAVLQLGVNNEDSK 104.76 0.00097851 5874600.0 57158.0 61167.0 62573.0 63499.0 60893.0 50271.0 58353.0 53080.0 44582.0 61100.0 True False 53981.38718160304 65858.31221709597 58547.12130433121 54850.32665811518 53243.076949673065 57195.37393529783 61066.5301242759 53234.45401213298 53499.645725158014 59335.88424313495 0.9097595471975896 1.1099238354186263 0.9867068141165353 0.9244039649491068 0.8973166512780703 0.9639255345202887 1.0291669350379857 0.8971713271179927 0.9016406582218891 1.0 15.856617239162587 -5.5375731037474925 9.21355087838019 0.9437547860022748 1.0194121200645085 0.15835555609924878 0.061283838620587824 0.2887979697223988 158.59329242307334 0.01632485990575566 0.028906850503770145 2.9001929750827875e-06 5.5375731037474925 0.07565733406223374 LKS(ph)PSMAVPSPGWVASPK ddPTM_A459_Selumetinib_30min_R1 2 LKSPSMAVPSPGWVASPK 18 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 LKS(0.963)PS(0.037)MAVPSPGWVASPK;LKS(0.837)PS(0.112)MAVPS(0.052)PGWVASPK 107.9 0.00085633 87540000.0 8189.5 8724.2 9658.0 9131.1 8101.8 7032.4 8060.0 7396.400000000001 4230.0 7140.0 True False 8380.299416006965 7702.766608229456 8346.496647596561 7536.524796975439 7368.9936204889655 6961.660440908316 7452.02771085677 7200.223445106826 7178.001053023594 8056.488549489544 1.0401925559166763 0.9560947751508317 1.0359968361309706 0.935460250539666 0.914665685332087 0.8641060429918197 0.9249721718190647 0.8937173311768722 0.8909590088697376 1.0 12.975935456407331 -5.91763232003727 4.640290240541546 0.9086423225823628 1.0048406133626484 0.5336246135735365 0.03981633781228033 0.1508018602645537 5.909028282516469 0.010719689908716615 0.01620612496001362 1.2088368206695725e-06 5.91763232003727 0.09619829078028563 LKS(ph)PSMAVPSPGWVASPK ddPTM_A459_Selumetinib_30min_R2 3 LKSPSMAVPSPGWVASPK 18 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 LKS(0.872)PS(0.114)MAVPS(0.013)PGWVASPK;LKS(0.928)PS(0.044)MAVPS(0.028)PGWVASPK;LKS(0.5)PS(0.5)MAVPSPGWVASPK 104.57 0.00098602 43488000.0 356508.8 320865.6 367398.7 395766.0 398355.3 298694.4 319260.2 348951.5 276148.5 346959.3 True False 336695.4681138019 345474.95977448294 343760.66763545905 341861.98806557053 348310.34587243316 339836.8423222024 334106.43190208444 349966.8910929693 331385.9162337668 336941.6835004771 0.9992692640930702 1.025325677088551 1.020237876371186 1.0146028372446427 1.03374074188105 1.0085924626233465 0.9915853343850564 1.0386571570996312 0.9835111903965351 1.0 18.36213939164532 -8.28407448885699 24.99542559760266 0.9917555920866297 1.0163373010789531 0.32876165628809495 0.014142031990199328 1046.68122916484 1155814.0859043044 0.01308977579915613 0.0033881243051298005 5.199068160638925e-09 8.28407448885699 0.02458170899232348 LKS(ph)PSQKQDGGTAPVASASPK ddPTM_A459_Selumetinib_30min_R2 1 LKSPSQKQDGGTAPVASASPK 21 2 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 LKS(0.698)PS(0.302)QKQDGGTAPVASASPK 60.38399999999999 0.022819 7311500.0 46847.0 53543.0 47048.0 62649.0 52165.0 28864.0 21005.0 21561.0 13878.0 47027.0 True False 44243.431283399615 57649.57593211973 44020.98290198925 54116.09812444697 45611.56633898304 32839.7539986958 21981.774120617883 21623.738940384297 16653.98778371862 45669.20831918014 0.968780342636644 1.2623292159831043 0.9639094812927013 1.184958095753092 0.9987378371047239 0.7190786792094175 0.48132592899329907 0.47348617889885264 0.3646655678225165 1.0 15.47893416020304 -6.832492787775168 2.4533293857572973 0.5380739445022739 1.0981747002585138 0.6341572164897126 0.17979478696144877 0.16260879044483054 1.9996395542591299 0.06608647540351814 0.058510408381853216 1.470642837816462e-07 6.832492787775168 0.56010075575624 LKS(ph)PVLSNTTTEPAS(ph)TMSPPPAK ddPTM_A459_Selumetinib_30min_R1 1 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 2 LKS(0.86)PVLS(0.056)NT(0.07)T(0.006)T(0.008)EPAS(0.467)T(0.404)MS(0.128)PPPAK 73.389 0.0025382 10681000.0 1559.7 1694.1 2217.9 2228.5 1641.4 1406.5 1553.0 1809.8 934.87 1637.6 True False 1596.0379753521063 1495.7539844342764 1916.7213620526438 1839.334309125928 1492.9356598127065 1392.3518869998222 1435.8559596725272 1761.7982249410984 1586.406109796731 1847.8019115748011 0.863749498988164 0.8094774526775494 1.0372980729406789 0.9954174728384946 0.8079522217510547 0.7535179384099572 0.7770616269407415 0.9534562194708385 0.8585368917844154 1.0 10.851594389626918 -1.5495665539202084 22.988636174261025 0.8806550886787144 0.004432095698853611 0.0 0.09760792921458862 0.0 0.0 0.02374372821210471 0.0 0.02821197212591957 1.5495665539202084 -0.8762229929798608 LKSPS(ph)MAVPSPGWVASPK ddPTM_A459_Selumetinib_30min_R2 1 LKSPSMAVPSPGWVASPK 18 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 LKS(0.122)PS(0.878)MAVPSPGWVASPK 88.551 0.012055 4054100.0 24661.0 24919.0 25730.0 28272.0 27035.0 17347.0 21016.0 24811.0 18573.0 24663.0 True False 23290.44034580481 26830.20717278619 24074.55981270582 24421.304828079683 23638.62160403349 19736.39178961253 21993.28564241398 24883.195902317828 22288.11897297923 23950.9151078304 0.9724238193383411 1.1202163696874552 1.0051624209062056 1.0196397389465715 0.9869611034738791 0.8240349774009265 0.918264940750577 1.038924641930806 0.9305748391088597 1.0 14.547793158529995 -6.403537499793478 3.82378108132227 0.9403957024645814 1.0340147956244765 0.2873375127519199 0.06339659398790862 0.30531272966119855 7.871322235452098 0.021081629896481324 0.023919918736255992 3.9487760159170226e-07 6.403537499793478 0.09361909315989514 LKSPVLSNT(ph)TTEPASTMS(ph)PPPAK ddPTM_A459_Selumetinib_30min_R2 1 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 2 LKS(0.041)PVLS(0.084)NT(0.656)T(0.167)T(0.052)EPAS(0.064)T(0.058)MS(0.878)PPPAK 85.412 0.00093071 4517000.0 21565.0 20696.0 21116.0 28187.0 26947.0 20764.0 23477.0 23953.0 20386.0 21543.0 True False 20366.50363153485 22283.316651871377 19757.419549362454 24347.88197471288 23561.676950763474 23624.052523174894 24568.727018792968 24022.699264367395 24463.769632431748 20920.997614563934 0.9734958153886946 1.0651173076163003 0.9443822858432206 1.1638011926239769 1.126221482591311 1.1292029643332715 1.1743573356984518 1.1482578272292447 1.1693404914592385 1.0 14.352664027466439 -5.7695218234737435 24.999494148288267 1.1379826573116596 1.0014103487943768 0.5564738218275318 0.05515727459375511 116.9967222021111 361878.7344910002 0.014359816188363933 0.021726511740408228 1.7001145200521177e-06 5.7695218234737435 -0.13657230851728275 LKSPVLSNTTTEPAS(ph)TMSPPPAK ddPTM_A459_Selumetinib_30min_R1 1 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLSNTTTEPAS(0.547)T(0.329)MS(0.123)PPPAK 136.74 2.6666000000000004e-06 28335000.0 3402.6 3948.7 4503.2 4707.2 4553.8 3629.5 4227.5 3807.0 1850.0 3650.8 True False 3481.873959692936 3486.384368299174 3891.690174306986 3885.1758850875335 4141.909594038691 3592.9905253223283 3908.6162714202233 3706.025993121206 3139.3148813460175 4119.415741803419 0.8452349017262878 0.846329816366844 0.9447189645887166 0.9431376021752689 1.0054604472199797 0.8722087670979697 0.9488278232653179 0.8996484514813168 0.7620777018178971 1.0 12.008224018630086 -5.249227453478447 23.31628795566909 0.9213400828604873 0.8457823186060268 0.17673570704349417 0.06579545420016157 545.5584874821492 1041623.697061607 0.016844372589223937 0.04372752177451805 5.633425386068936e-06 5.249227453478447 -0.07555776425446048 LKSPVLSNTTTEPAS(ph)TMSPPPAK ddPTM_A459_Selumetinib_30min_R2 1 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLSNTTTEPAS(0.387)T(0.226)MS(0.387)PPPAK 122.64 1.9577e-05 3521500.0 22320.0 23899.0 23667.0 28309.0 24491.0 20722.0 18872.0 20579.0 21620.0 22798.0 True False 21079.543754039325 25731.976452603132 22144.29098668125 24453.265364251118 21414.221627682047 23576.267404412938 19749.585394158566 20638.88148296315 25944.604113272562 22139.76250368235 0.9521124605800679 1.1622516930036317 1.0002045407216158 1.1044953784027258 0.9672290578600549 1.0648834828508962 0.8920414295715123 0.9322088021283169 1.1718555747360606 1.0 14.43435212576117 -6.270074848130731 24.83698010976133 0.9986894391530792 1.058546318729398 0.067946829141867 0.08874185098418111 1464.1666900835912 4211175.673077926 0.026625399653316 0.030652162603155345 5.369392500354115e-07 6.270074848130731 0.0598568795763188 LKSPVLSNTTTEPAS(ph)TMSPPPAKK ddPTM_A459_Selumetinib_30min_R1 1 LKSPVLSNTTTEPASTMSPPPAKK 24 2 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLSNTTTEPAS(0.484)T(0.484)MS(0.032)PPPAKK 103.71 1.8353e-06 9696800.0 1705.8 1708.1 2125.7 2145.7 1882.9 1622.8 1761.1 1887.5 953.73 1319.1 True False 1745.5418210909927 1508.1148579258543 1837.0416156342956 1770.993774777431 1712.592027452995 1606.4761053845084 1628.2588091302553 1837.4373685359278 1618.4101523168313 1488.4193341220807 1.172748687869317 1.0132325100542923 1.234223161121354 1.1898486764968168 1.150611247913639 1.0793168756653255 1.0939516652346206 1.2344890491628218 1.087334808957869 1.0 10.53956532053731 -6.662707650117923 13.826770093776586 1.1133621367633628 1.1511205601830987 0.09457921047569717 0.07590970411848229 2.4722246461722235 332.59137279077174 0.025250321640065684 0.02524861523989837 2.1741642478179444e-07 6.662707650117923 0.0377584234197359 LKSPVLSNTTTEPAST(ph)MSPPPAK ddPTM_A459_Selumetinib_30min_R2 1 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLSNTTTEPAS(0.127)T(0.853)MS(0.02)PPPAK 124.69 1.4377e-05 17575000.0 48018.0 48754.0 50369.0 52367.0 48285.0 45213.0 49282.0 49453.0 47394.0 46183.0 True False 45349.35179128402 52493.27503118177 47128.31337762066 45234.52426188629 42219.006626623115 51440.680347250316 51573.71065043043 49596.90004261514 56874.12429900271 44849.57679215553 1.0111433604255526 1.170429662568481 1.0508084300555471 1.0085830792008297 0.9413468230096539 1.1469602173871039 1.1499263613887878 1.1058499007127742 1.2681083828855737 1.0 15.452806751254986 -6.84008065027484 24.999962402431034 1.1417705349918987 1.0431477130202707 0.2605316708695765 0.08141607753504211 46.788209950753824 14871.24724721044 0.028610424147386328 0.025232027408766285 1.4451713715466228e-07 6.84008065027484 -0.09862282197162808 LKSPVLSNTTTEPASTMS(ph)PPPAK ddPTM_A459_Selumetinib_30min_R1 1 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLSNTTTEPAS(0.364)T(0.22)MS(0.415)PPPAK 136.2 2.8338e-06 34890000.0 4584.4 5411.8 6186.2 6073.6 6188.8 5644.1 5042.0 5121.9 2980.6 4269.8 True False 4691.207600310439 4778.183940122436 5346.148018364245 5012.959775592209 5629.024132721388 5587.325478432776 4661.677880662511 4986.050573724059 5057.860505589154 4817.870421374011 0.9737097908441779 0.9917626507604875 1.1096496067321742 1.0404928603626828 1.1683635383278 1.1597085412768997 0.9675805849782577 1.0349075706984425 1.0498124821187491 1.0 12.234179876877938 -5.146322834544443 5.865026566970772 1.069940062743025 0.9786614696643438 0.2304740297548722 0.06104467957242018 0.33198686647166936 14.646901169964075 0.016516213579475313 0.04556962710005603 7.13965399724289e-06 5.146322834544443 -0.09127859307868136 LKSPVLSNTTTEPASTMS(ph)PPPAK ddPTM_A459_Selumetinib_30min_R2 2 LKSPVLSNTTTEPASTMSPPPAK 23 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLSNTTTEPAS(0.063)T(0.381)MS(0.556)PPPAK;LKSPVLSNTTT(0.001)EPAS(0.278)T(0.278)MS(0.442)PPPAK 124.17 5.7263e-06 17208700.0 88003.0 76615.0 90392.0 91497.0 104428.0 77282.0 80445.0 87999.0 67269.0 91663.0 True False 83112.14556392113 82491.1241439471 84576.27713136826 79034.9507588712 91308.8210418349 87926.89400385281 84185.85189874342 88255.0625209813 80724.67965290166 89016.45102092419 0.9336717495554255 0.9266952703445429 0.9501196257699352 0.8878690382780287 1.0257522064137545 0.987760048793506 0.945733636122549 0.9914466540598893 0.9068512474612871 1.0 16.44178436296626 -6.2524875514425 24.998267415136688 0.9748785866332506 0.9265629992498392 0.3621026239622894 0.03352533715665801 789.8837211815619 2205774.75835375 0.009782314468648854 0.012451978132669052 5.591295541537668e-07 6.2524875514425 -0.04831558738341135 LKSPVLSNTTTEPASTMS(ph)PPPAKK ddPTM_A459_Selumetinib_30min_R2 1 LKSPVLSNTTTEPASTMSPPPAKK 24 2 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LKSPVLS(0.006)NT(0.021)T(0.1)T(0.075)EPAS(0.037)T(0.146)MS(0.613)PPPAKK 80.016 0.00010345 9986700.0 56833.0 61708.0 54591.0 62982.0 61824.0 48023.0 50538.0 51211.0 38316.0 57903.0 True False 53674.44938052491 66440.80517750671 51078.67449418667 54403.74294998994 54057.11640642746 54637.732340610106 52888.11713914718 51360.015531562574 45980.27063848986 56231.18993993855 0.9545316298277782 1.1815649864154256 0.9083690839326828 0.96750118587388 0.9613368748583615 0.9716623887733757 0.9405477137445933 0.9133723754809572 0.8177004734845935 1.0 15.779082956434994 -5.288471237683273 24.99826889508379 0.9355675224382726 1.0680483549062059 0.37056969701187226 0.06932539893055517 638.3731902044638 590347.9202993336 0.01742302491269562 0.03628705797688755 5.146698912788116e-06 5.288471237683273 0.1324808324679333 LKTEEGEIDYS(ph)AEEGENR ddPTM_A459_Selumetinib_30min_R1 1 LKTEEGEIDYSAEEGENR 18 1 B7WPG3;V9GYK2;Q8WVV9-2;Q8WVV9-5;Q8WVV9;C9IYN3;Q8WVV9-3;Q8WVV9-4 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1 LKTEEGEIDYS(1)AEEGENR 98.002 0.0018578 9794200.0 2728.7 3130.0 3263.5 3000.7 2802.5 2661.2 3185.4 3289.4 1957.4 2882.2 True False 2792.273400874071 2763.538144902476 2820.334625122323 2476.684075115178 2549.014369821562 2634.4307441762726 2945.1227134197457 3202.154426522957 3321.5648371603747 3252.158445005428 0.8585908245529564 0.8497550754781455 0.8672193168982011 0.761550864447825 0.7837915688690585 0.8100560869726862 0.9055901682597234 0.9846243596897114 1.0213416392001256 1.0 11.667181831821368 -7.593849717225369 2.3029789287058944 1.008247515735273 0.8207711402490959 0.8667758855592552 0.03171766845341787 0.11628708248056016 1.2341926626275928 0.021293018188472502 0.01063083076479552 2.547711707364547e-08 7.593849717225369 -0.18747637548617713 LKTEEGEIDYS(ph)AEEGENR ddPTM_A459_Selumetinib_30min_R2 1 LKTEEGEIDYSAEEGENR 18 1 B7WPG3;V9GYK2;Q8WVV9-2;Q8WVV9-5;Q8WVV9;C9IYN3;Q8WVV9-3;Q8WVV9-4 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1 LKTEEGEIDY(0.004)S(0.995)AEEGENR 71.428 0.011965 8422700.0 36618.0 38981.0 57538.0 42949.0 51735.0 40743.0 41307.0 36129.0 34330.0 45163.0 True False 34582.91815346826 41970.71735632963 53836.06772263767 37099.27210884249 45235.586783231796 46354.9784218703 43227.85734826769 36234.129408522094 41196.95926034445 43859.0268424338 0.7885017211555897 0.956945932866043 1.2274797595497728 0.8458754053555237 1.031386011954697 1.0569085034285726 0.9856091313554761 0.8261498719224982 0.9393039979739407 1.0 15.420586180955153 -10.364123477279367 4.639854740160705 1.0000000845554065 0.9677892834399334 0.006713691364784835 0.12154884035259356 37900622.31286198 42329623.34321151 39.52573583051134 0.02970191847104579 4.323908775045666e-11 10.364123477279367 -0.03221080111547303 LKTEEGEIDYS(ph)AEEGENRR ddPTM_A459_Selumetinib_30min_R1 3 LKTEEGEIDYSAEEGENRR 19 2 B7WPG3;V9GYK2;Q8WVV9-2;Q8WVV9-5;Q8WVV9;C9IYN3;Q8WVV9-3;Q8WVV9-4 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1 LKTEEGEIDYS(1)AEEGENRR;LKTEEGEIDYS(1)AEEGENRR;LKTEEGEIDYS(1)AEEGENRR 110.57 0.00073472 88595000.0 6295.7 7474.1 9131.4 10640.0 8560.3 7562.300000000001 7594.799999999999 7271.9 4277.81 5556.5 True False 6442.377560700291 6599.028897385181 7891.406035189824 8781.923737536408 7786.022376443718 7486.230128019027 7021.918121391443 7079.025589539817 7259.131131119357 6269.73089989337 1.0275365344324199 1.0525218709940822 1.2586514734346945 1.4006859110469578 1.2418431509677927 1.1940273430469472 1.1199712130405572 1.1290796531092284 1.1578058527588182 1.0 12.61418780779774 -7.265713357851275 3.7543433042794474 1.1105633795807373 1.2044651636019175 0.1560306029207229 0.1058464368755087 0.5367640882609563 17.0706681467833 0.05097836502886733 0.03548625417890582 5.423587387922567e-08 7.265713357851275 0.09390178402118021 LKTEKEPDATPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LKTEKEPDATPPSPR 15 2 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 LKTEKEPDATPPS(1)PR 107.63 0.0047387 39698000.0 2959.9 3884.9 4712.6 5247.4 4425.6 4017.7 4043.0 3648.8 1863.2 2752.5 True False 3028.859911037184 3430.054101958987 4072.654804458853 4331.04009589742 4025.3052614031394 3977.2855857797254 3738.0332549620243 3552.0219710272268 3161.714317256164 3105.8101866204424 0.9752237674038312 1.104399140918321 1.311301901836594 1.3944960688696173 1.2960564295731274 1.280595189916474 1.2035613995553056 1.143670011235402 1.0179998542333824 1.0 11.6007539459426 -8.081396533939277 1.9158289210085282 0.9975804034032434 1.235595907643861 0.3716704842988816 0.11054202725448159 0.4098120451444057 2.684935970983158 0.1093053678827958 0.03466414862970484 8.290934154714772e-09 8.081396533939277 0.23801550424061757 LKTPS(ph)TPVACSTPAQLK ddPTM_A459_Selumetinib_30min_R2 1 LKTPSTPVACSTPAQLK 17 1 Q6PL18;A0A0B4J211 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 LKT(0.101)PS(0.554)T(0.345)PVACSTPAQLK 98.292 0.0028863000000000005 9090700.0 47446.0 62513.0 67197.0 80056.0 75095.0 45024.0 50500.0 37040.0 41479.0 62073.0 True False 44809.141261386605 67307.54608902379 62873.61817856173 69152.234695697 65660.8947421822 51225.64731282155 52848.35006385164 37147.78026769792 49775.959020093986 60280.791204977344 0.7433402973928906 1.1165670646251613 1.043012490741334 1.1471686637382281 1.0892507120371144 0.8497839243455697 0.8767029929011282 0.6162457314367608 0.8257349982490612 1.0 15.879410732450781 -6.863643206029454 4.656383809189839 0.806198527234186 1.0398897649682781 0.3270591583210144 0.13688104851903196 0.22399505438872405 8.25754604413656 0.04896091124711366 0.04328206703393321 1.3688529428258026e-07 6.863643206029454 0.23369123773409217 LKTPST(ph)PVACSTPAQLK ddPTM_A459_Selumetinib_30min_R2 1 LKTPSTPVACSTPAQLK 17 1 Q6PL18;A0A0B4J211 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 LKT(0.05)PS(0.193)T(0.757)PVACSTPAQLK 100.39 0.0060993 10881000.0 62986.0 66380.0 71575.0 67270.0 73416.0 51666.0 51105.0 51875.0 37246.0 68938.0 True False 59485.49027293547 71471.1325546589 66969.94242496765 58107.709952777346 64192.82573263252 58782.52252274867 53481.48376263635 52025.94766163144 44696.240740191904 66947.58081756516 0.8885383093234663 1.0675685615798516 1.000334016660937 0.8679583226632667 0.9588520593083197 0.8780380381919012 0.7988561066661324 0.7771146772786941 0.6676304086624273 1.0 16.030744303574615 -6.938390842589617 1.4739738060836869 0.788158833054416 0.968922381891434 0.34067448662272326 0.09317441286718155 0.39934290923787996 1.778624725959179 0.04482115858833494 0.03494499168981894 1.1524156764537063e-07 6.938390842589617 0.18076354883701795 LLAASGSNS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 LLAASGSNSPTR 12 0 Q9NS37;E9PIM0 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 LLAAS(0.004)GS(0.043)NS(0.645)PT(0.308)R 98.0 0.015686000000000002 9674300.0 20362.0 16998.0 19240.0 24631.0 25253.0 20197.0 23384.0 28848.0 24474.0 20521.0 True False 19230.36155554428 18301.6919428155 18002.11934692809 21276.21530915503 22080.49237531561 22978.95341988843 24471.402334516963 28931.942903956522 29369.48386069531 19928.505410038837 0.9649675758352219 0.918367512578046 0.9033351461399437 1.0676272440600234 1.1079853667396817 1.1530695828455328 1.227959740633117 1.4517868906206217 1.4737424235487648 1.0 14.282545895126349 -6.68101903898868 0.9982039938990598 1.3328591930079412 0.9322039702980518 0.5603086581018054 0.12864893127165183 0.3581379365959774 0.7701134029033233 0.07046360914081297 0.06976175633584872 2.0843995033305988e-07 6.68101903898868 -0.4006552227098894 LLAAVEAFYS(ph)PPSHDRPR ddPTM_A459_Selumetinib_30min_R1 2 LLAAVEAFYSPPSHDRPR 18 1 J3QK89;Q8IWX8 J3QK89 CHERP Calcium homeostasis endoplasmic reticulum protein 1 LLAAVEAFY(0.269)S(0.729)PPS(0.002)HDRPR;LLAAVEAFY(0.409)S(0.572)PPS(0.018)HDRPR 85.054 0.0033308 13845400.0 5624.5 6900.1 6648.8 6613.4 6215.2 5819.1 6107.6 5659.9 3028.8 4675.0 True False 5755.539906628144 6092.233084230537 5745.929479244158 5458.49383889316 5653.03625738268 5760.56513732006 5646.898814743033 5509.7810660537725 5139.652385200446 5275.081788356246 1.0910806955320427 1.154907796439858 1.0892588418111773 1.0347695178758671 1.071649025397236 1.092033331129657 1.0704855472018469 1.0444920642208015 0.974326577560421 1.0 12.36497774715323 -7.116332051386491 0.3149880957276873 0.9832751201716338 1.1333529892688134 0.5941091627515213 0.03112357413017409 1.4330751992127524 0.3527458338894588 0.04699781237803868 0.07751614177468233 7.65011473399709e-08 7.116332051386491 0.15007786909717968 LLAQAEGEPCY(ph)IR ddPTM_A459_Selumetinib_30min_R1 2 LLAQAEGEPCYIR 13 0 H0YE41;E9PPF2;E9PM19;P29597 H0YE41 TYK2 Tyrosine-protein kinase;Non-receptor tyrosine-protein kinase TYK2 1 LLAQAEGEPCY(1)IR;LLAQAEGEPCY(1)IR 158.3 0.00050833 10901000.0 3521.5 4507.1 3145.1000000000004 3666.6000000000004 3177.7 3604.4 3384.8 3550.3 1609.55 3187.4 True False 3603.5440983538115 3979.4066367060586 2718.012694797677 3026.2971406062975 2890.2775960685026 3568.1430085333504 3129.481810881887 3456.1345110003213 2731.2887931191813 3596.533837905176 1.0019491712756188 1.1064560535384507 0.7557311615287904 0.841448260186253 0.803628639777226 0.9921060580404932 0.8701382920130327 0.9609626008727805 0.7594225207429267 1.0 11.812391462393569 -5.2486517480571475 24.979650545351266 0.8720927286014246 1.0542026255704118 0.40892443145257096 0.08717052837970571 722.1687244866902 1410694.645231316 0.02148938805698912 0.056033444409535706 5.640898066995589e-06 5.2486517480571475 0.18210989696898716 LLAQAEGEPCY(ph)IR ddPTM_A459_Selumetinib_30min_R2 2 LLAQAEGEPCYIR 13 0 H0YE41;E9PPF2;E9PM19;P29597 H0YE41 TYK2 Tyrosine-protein kinase;Non-receptor tyrosine-protein kinase TYK2 1 LLAQAEGEPCY(1)IR;LLAQAEGEPCY(1)IR 147.28 0.0080755 10843900.0 31303.0 29798.0 30920.0 34898.0 37545.0 31603.0 29086.0 41357.0 36171.0 39596.0 True False 29563.304575837497 32083.410784328553 28930.64086315057 30144.83219759216 32828.26144344134 35956.02638652937 30438.55663281559 41477.34202298006 43406.2107021823 38452.760597236884 0.7688213828258105 0.8343591015578211 0.7523683713160884 0.783944552468836 0.8537296395255506 0.935070091927628 0.7915831310952178 1.078657068537246 1.1288191024001892 1.0 15.230799555291227 -7.765163684647041 24.995931813386527 1.0778036553712753 0.8199653953256166 0.8035600007633483 0.05704484398416131 41.04593389056197 275473.8943216843 0.03107927198979282 0.015834076404173905 1.7172610332181843e-08 7.765163684647041 -0.2578382600456587 LLAS(ph)PSSR ddPTM_A459_Selumetinib_30min_R1 1 LLASPSSR 8 0 C9J470;E9PHA2;Q15003;C9JZP1 C9J470 NCAPH Condensin complex subunit 2 1 LLAS(0.622)PS(0.345)S(0.033)R 104.01 0.014949 42573000.0 4069.1 4528.2 4772.3 4991.9 4073.0 3771.6 4557.6 3798.9 1936.8 3474.3 True False 4163.9021129096955 3998.0362388969306 4124.247872367479 4120.1583745684175 3704.597869146555 3733.6611283388042 4213.816562655191 3698.1408314337127 3286.608141724846 3920.2602475478307 1.0621494110025644 1.019839496981801 1.0520342048585283 1.0509910348797955 0.944987739388941 0.95240134393482 1.0748818436967247 0.9433406452408214 0.8383647855472499 1.0 11.93673371588623 -6.539442798656638 0.5956745136006478 0.9396710827356236 1.0575233003367537 0.31938347820258683 0.05800076463745196 1.1819180756687417 0.9156406479898477 0.047129414522807486 0.06773824552392492 2.8877341003742027e-07 6.539442798656638 0.11785221760113007 LLAS(ph)PSSR ddPTM_A459_Selumetinib_30min_R2 5 LLASPSSR 8 0 C9J470;E9PHA2;Q15003;C9JZP1 C9J470 NCAPH Condensin complex subunit 2 1 LLAS(0.63)PS(0.37)SR;LLAS(0.86)PS(0.14)SR;LLAS(0.478)PS(0.478)S(0.043)R;LLAS(0.992)PS(0.008)SR;LLAS(0.741)PS(0.259)S(0.001)R 112.11 0.011314 100073400.0 220836.0 218907.0 243879.0 265732.0 257379.0 212688.0 217596.0 213153.0 215614.0 240086.0 True False 208562.81919655157 235696.4630030539 228188.0906553785 229538.84318673125 225044.74902254628 241983.8414105676 227714.6451582944 213773.23994062134 258742.8247585172 233154.09336165816 0.8945278042922381 1.0109042462207694 0.9787007698012978 0.9844941595371474 0.9652189493129206 1.0378708686671572 0.9766701578130721 0.9168753456497368 1.1097502987312642 1.0 17.83092423296182 -4.755380087884693 24.964498058898517 0.9937901467766486 0.894527638848996 0.2908371222379643 0.04802158147398832 256.2280898131331 1055563.415484294 0.011212772641008527 0.10038259884425023 1.756385779155597e-05 4.755380087884693 -0.09926250792765257 LLAS(ph)SPALPSSGAQAR ddPTM_A459_Selumetinib_30min_R1 2 LLASSPALPSSGAQAR 16 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 LLAS(0.5)S(0.5)PALPSSGAQAR;LLAS(0.618)S(0.382)PALPSSGAQAR 205.26 1.468e-07 31179000.0 2958.0 3640.8999999999996 4198.2 4200.2 3991.8 3387.3 3375.7 3166.2 2213.3900000000003 2757.85 True False 3026.915644733941 3214.6217353915094 3628.1074990619068 3466.713917518833 3630.74239480953 3353.226837422324 3121.0682312083395 3082.222090732956 3755.9611703905207 3111.8469112338553 0.9727071193016243 1.0330269537960348 1.1659016662948092 1.1140374242074371 1.166748396812982 1.0775680594431174 1.0029632948655651 0.9904799878188246 1.2069877720627562 1.0 11.603555372673753 -10.055499924992198 15.137755515437096 0.9999802423242807 1.0806467002073008 0.09008553691108423 0.07736390474240501 0.0 0.0 0.07749134570470176 0.018794411965396402 8.800352636798259e-11 10.055499924992198 0.08066645788302007 LLASQGSQGAPLLS(ph)TPKR ddPTM_A459_Selumetinib_30min_R2 1 LLASQGSQGAPLLSTPKR 18 1 H3BRB3;Q14807-2;Q14807 H3BRB3 KIF22 Kinesin-like protein;Kinesin-like protein KIF22 1 LLASQGSQGAPLLS(0.645)T(0.355)PKR 121.35 0.00093619 0.0 30492.0 27972.0 22940.0 38104.0 28831.0 25607.0 29774.0 18355.0 19643.0 31189.0 True False 28797.37670914725 30117.36245584396 21464.06537518351 32914.16946693368 25208.99202758977 29134.13181279808 31158.549996061734 18408.410011166183 23572.14887127718 30288.49253124609 0.9507695597408626 0.9943499969427138 0.7086541316983946 1.0866889275845901 0.8322960279909531 0.9618878121036512 1.0287256773812061 0.6077691054507177 0.7782542774936645 1.0 14.88648215603812 -7.746381440474765 24.99897029813162 0.7697586837212691 0.9336151154809594 0.18558338875010438 0.13321295957075827 316.7545668629156 525873.0814306423 0.059814020641902256 0.03435877053819793 1.7931580058462796e-08 7.746381440474765 0.16385643175969034 LLASS(ph)PALPSSGAQAR ddPTM_A459_Selumetinib_30min_R1 1 LLASSPALPSSGAQAR 16 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 LLAS(0.002)S(0.998)PALPSSGAQAR 210.07 1.8979999999999998e-29 0.0 1729.0 2761.5 2747.9 2522.0 2575.1 1953.2 2181.0 2536.5 1196.6 2034.7 True False 1769.2823359516508 2438.1822962134784 2374.7502731342506 2081.5800438032716 2342.1826596708297 1933.5525813637057 2016.4854140668258 2469.223780286825 2030.5428037938614 2295.873564656354 0.7706357890036843 1.0619845682044016 1.034355859003805 0.9066614450586447 1.0201705772161749 0.8421860032406094 0.8783085641602624 1.075505122886163 0.8844314578350018 1.0 11.164827478650498 -10.752530806438804 3.8303201584262325 1.000045605027593 0.9482908912614879 0.02724120335556479 0.09757649704495518 136141718.6442726 268031292172.73425 27596095.30912611 0.023574972698924713 1.7679468049578218e-11 10.752530806438804 -0.051754713766105076 LLDEEEATDNDLR ddPTM_A459_Selumetinib_30min_R1 2 LLDEEEATDNDLR 13 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 ; 290.07 1.9199e-59 11104900.0 2503.82 2408.9 2474.6000000000004 2832.8999999999996 3011.7 2034.0099999999998 2491.29 2642.8 1585.46 2188.9 False True 2562.15413441438 2126.864868132772 2138.5629120048097 2338.1871951190665 2739.292266758821 2013.5497061333156 2303.369989550915 2572.7043589757604 2690.409822583165 2469.8666366915477 1.0373653768798035 0.8611253889326446 0.8658616948117781 0.9466856065763659 1.1090850923142053 0.815246327967942 0.9325888108016798 1.0416369534923418 1.089293560476221 1.0 11.27021742858615 -7.7752464408744215 6.744704894033508 1.0500858644055333 0.9345497781118515 0.24934542701865503 0.08343412120278298 0.20837742519581468 40.5844964171193 0.04476301007853218 0.02256678610688114 1.677851649200021e-08 7.7752464408744215 -0.11553608629368184 LLDEEEATDNDLR ddPTM_A459_Selumetinib_30min_R2 3 LLDEEEATDNDLR 13 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 ;; 231.07 5.1513e-12 17562000.0 49448.0 36513.0 45894.0 46793.0 50752.0 37630.0 32507.8 35889.0 31022.0 39116.0 False True 46699.878116027576 39313.429692200436 42941.230005609075 40419.71267757264 44376.08003136334 42813.19092887069 34019.477112983695 35993.43104825622 37227.2668271018 37986.619444426644 1.229377049051395 1.0349283581213347 1.1304304155949145 1.0640513230377224 1.1682029272513785 1.1270597793390165 0.8955647438633815 0.9475291977722208 0.9800099975088397 1.0 15.2132037070362 -7.2508637478170375 24.798848013751456 0.9514034184009603 1.1208983080274524 0.6897196496896887 0.055740054693969684 350.5773582843656 822072.224214818 0.02056344945127324 0.0157573670783834 5.612240224880365e-08 7.2508637478170375 0.16949488962649206 LLDESESAAS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 LLDESESAASSR 12 0 Q8N108-17;Q8N108;Q8N108-13;Q8N108-12;Q8N108-19;Q8N108-16;Q8N108-14;Q8N108-18;Q8N108-15 Q8N108-17 MIER1 Mesoderm induction early response protein 1 1 LLDES(0.002)ES(0.013)AAS(0.585)S(0.4)R 103.11 0.012471 0.0 10787.0 11557.0 7148.9 10932.0 8079.7 7998.5 10035.0 12326.0 10714.0 9308.2 True False 10187.501723782354 12443.384738387975 6688.947557133801 9443.042741248135 7064.655852565536 9100.220771846187 10501.64738397526 12361.866619320856 12857.099374172165 9039.448080391961 1.1270048384791 1.3765646561298037 0.7399730047283771 1.044648152991955 0.7815361944375706 1.0067230533229181 1.161757586368027 1.3675466145035737 1.4223323437258644 1.0 13.142018973675418 -7.473357920017045 3.504903677051113 1.2943741077855428 1.0090739094688708 0.24617629524970575 0.1959268323976111 0.31840721265910404 7.893242398391198 0.09576523926768943 0.057975079302785996 3.362343505441112e-08 7.473357920017045 -0.2853001983166721 LLDHMAPPPVADQAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LLDHMAPPPVADQASPR 17 0 A0A0C4DFS6;Q9C004 A0A0C4DFS6 SPRY4 Protein sprouty homolog 4 1 LLDHMAPPPVADQAS(1)PR 88.87200000000001 0.0065101 4302500.0 1432.9 1371.2 1646.4 1382.9 1519.1 1586.2 1427.4 1742.9 1132.8 1726.5 True False 1466.2837820619557 1210.659266546415 1422.8279230278506 1141.4024752480357 1381.697673218889 1570.2442681543673 1319.7300687936665 1696.6726302629238 1922.2788635614966 1948.1130925341304 0.7526687170684712 0.6214522509941012 0.7303620762473383 0.5859015473086754 0.709249210692157 0.8060334249444284 0.6774401721601002 0.8709312805119904 0.9867388453618838 1.0 10.927861716344255 -7.979828452240263 1.9150909929239437 1.0054633002190276 0.6924028652847621 0.7974656630860281 0.060593783971245124 0.15020642439627208 1.0072502262396827 0.05102438594237226 0.01728102664506287 1.0475422489991279e-08 7.979828452240263 -0.3130604349342655 LLDHMAPPPVADQAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 LLDHMAPPPVADQASPR 17 0 A0A0C4DFS6;Q9C004 A0A0C4DFS6 SPRY4 Protein sprouty homolog 4 1 LLDHMAPPPVADQAS(1)PR;LLDHMAPPPVADQAS(1)PR 85.397 0.007770999999999998 6378300.0 56124.0 32098.0 50644.0 54101.0 47453.0 33526.0 51763.0 53542.0 41893.0 44625.0 True False 53004.85276217307 34559.8133886629 47385.62017701804 46732.350470569465 41491.529904797535 38143.9021812734 54170.08206643864 53697.798355644765 50272.7705882205 43336.56030032569 1.223097827673571 0.7974747683978779 1.0934328855043423 1.0783585533025852 0.9574255459422263 0.880178350956634 1.2499857323939836 1.2390876890901101 1.1600544722475974 1.0 15.40329702826032 -7.271896130130824 24.887671322575056 1.1822059493400314 1.0007543411336033 0.2610069072080351 0.1277913297468168 808.3381407170499 1923883.5957279024 0.050999058009302926 0.03480963594554452 5.3469222602404325e-08 7.271896130130824 -0.18145160820642814 LLDLSDSTSVAS(ph)FPSADETDGNLPESR ddPTM_A459_Selumetinib_30min_R2 2 LLDLSDSTSVASFPSADETDGNLPESR 27 0 Q13464 Q13464 ROCK1 Rho-associated protein kinase 1 1 LLDLSDST(0.001)S(0.003)VAS(0.995)FPS(0.002)ADETDGNLPESR;LLDLSDS(0.001)T(0.001)S(0.003)VAS(0.839)FPS(0.012)ADET(0.143)DGNLPES(0.002)R 101.76 5.269300000000001e-07 1668500.0 14039.7 15445.7 16576.1 15708.6 18412.4 10757.599999999999 13725.4 14637.4 11284.1 13749.3 True False 13259.42967937212 16630.33552424671 15509.611772693084 13569.061581153524 16099.269703055534 12239.361752230117 14363.658296364143 14679.992410647978 13541.235304097077 13352.3219840284 0.9930429849753928 1.245501385012986 1.1615666392141504 1.016232352499017 1.2057280915119437 0.9166466901315315 1.0757423550409786 1.0994336736492494 1.0141483496499448 1.0 13.704803029593283 -6.747953111583912 24.999326024892937 1.030818050168229 1.1271952400531788 0.26457474127760783 0.08523133815027563 349.8583950583931 648527.3287244448 0.027686786723563794 0.027544646915451963 1.7866804626234972e-07 6.747953111583912 0.09637718988494992 LLDPEDISVDHPDEK ddPTM_A459_Selumetinib_30min_R2 1 LLDPEDISVDHPDEK 15 0 A0A087WUZ3;Q01082;Q01082-2;F8W6C1;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 147.1 0.0004646 1933700.0 18254.0 18678.0 21522.0 17823.0 21688.0 17021.0 15094.0 19756.0 18597.0 17846.0 False True 17239.515756551697 20110.54254076411 20137.29795138184 15395.476653610096 18963.359546819982 19365.488248745896 15795.900908193598 19813.486689218138 22316.91964359527 17330.739610523513 0.9947362976986612 1.160397247475385 1.1619410598699513 0.8883335044894279 1.094203708150177 1.117406913031389 0.9114383611535001 1.143256845033149 1.2877072845779798 1.0 14.081045604137877 -7.9771794193185706 24.99865212363709 1.1677299039379954 1.0522267298252306 0.13027093500399967 0.11057305932686612 376.89126988053147 412862.8348681531 0.05904949485166797 0.028363803541505545 1.0539513893460103e-08 7.9771794193185706 -0.11550317411276478 LLDPEDVDVPQPDEK ddPTM_A459_Selumetinib_30min_R2 2 LLDPEDVDVPQPDEK 15 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 180.61 0.00028032 7968500.0 77577.0 71901.0 75438.0 80240.0 70463.0 59342.0 63538.0 60858.0 53514.0 68203.0 False True 73265.58090533642 77415.57550184595 70584.40121068394 69311.17357827931 61610.80799278756 67515.82184695834 66492.64289815853 61035.08670441574 64218.29530609004 66233.80217732467 1.1061660133776692 1.1688227605382646 1.0656854791713695 1.0464622488788389 0.9302018903858156 1.019355972743364 1.0039079852329915 0.921509632513763 0.9695698147323838 1.0 16.015280058630978 -5.7586296303426145 1.7436824162056805 0.9740380080150768 1.13658842698425 0.7605622728444634 0.035699331330870075 0.1649776827110949 1.0205058288159894 0.011153580288980645 0.023531754108427578 1.7432929331930564e-06 5.7586296303426145 0.16255041896917333 LLDPS(ph)SPLALALSAR ddPTM_A459_Selumetinib_30min_R1 1 LLDPSSPLALALSAR 15 0 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 LLDPS(0.735)S(0.265)PLALALSAR 150.12 0.00027193 7180100.0 2344.6 2979.9 3205.9 3292.0 2955.3 2458.6 2794.2 3026.2 1503.0 2353.4 True False 2399.2246182025683 2631.0119226820725 2770.556388748169 2717.113998493407 2687.993636800594 2433.8687162301917 2583.431244376673 2945.9353455170467 2550.4812252232773 2655.48181405724 0.9034987946450503 0.9907851406680204 1.0433347252019434 1.0232094168786645 1.012243285783863 0.9165450515782476 0.9728672328693214 1.1093788441412937 0.9604589313027396 1.0 11.374757933897278 -4.777397150568536 4.2107898177873215 1.00595217211561 0.8950962726014936 0.27766362575263637 0.04862606296745324 0.2891306221123031 10.280602900004435 0.012565243402105717 0.09662325098054914 1.669563145619688e-05 4.777397150568536 -0.11085589951411634 LLDPSS(ph)PLALALSAR ddPTM_A459_Selumetinib_30min_R1 1 LLDPSSPLALALSAR 15 0 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 LLDPS(0.046)S(0.954)PLALALSAR 149.35 0.00028702 10345000.0 1187.4 1428.0 1471.5 1482.2 1574.0 1290.3 1454.7 1152.9 711.47 963.34 True False 1215.0641097217988 1260.80909614081 1271.6783823709204 1223.3615943398925 1431.631977912271 1277.3207534986643 1344.9708078143112 1122.321346853018 1207.3126262871629 1086.9940727262265 1.117820363706646 1.1599042973423472 1.1699036952257689 1.125453785844159 1.3170559194694393 1.1750944973371296 1.2373303972496081 1.0324999694231904 1.1106892453048731 1.0 10.086128358171933 -7.769250574279022 24.985402722621114 1.0536959170105291 1.1867346581057945 0.5284667170835342 0.059805941534356 149.57148631195363 478420.0672913631 0.03218981344379757 0.015919667280283774 1.7011766996477712e-08 7.769250574279022 0.13303874109526537 LLEDGEDFNLGDALDSS(ph)NSMQTIQK ddPTM_A459_Selumetinib_30min_R1 2 LLEDGEDFNLGDALDSSNSMQTIQK 25 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 LLEDGEDFNLGDALDS(0.14)S(0.818)NS(0.043)MQTIQK;LLEDGEDFNLGDALDS(0.184)S(0.407)NS(0.407)MQT(0.002)IQK 187.57 1.1638e-26 29029300.0 11325.099999999999 15684.400000000001 13518.099999999999 15758.2 14057.800000000001 14105.4 15072.0 14581.3 7969.3 12844.0 True False 11588.952795191459 13848.063156520264 11682.416269608117 13006.326188049448 12786.27447210617 13963.512482678492 13935.106905463192 14194.556557262473 13523.320045357192 14492.652511154583 0.7996433217640297 0.9555230242263659 0.8060923464918857 0.8974427681915956 0.8822590938591081 0.9634890833083297 0.961529084806093 0.9794312356787224 0.9331155932255104 1.0 13.82303404721664 -6.7161209741253876 2.909093149124371 0.9674552657227187 0.8683086181501332 0.5591115744056026 0.044209114217097514 0.2001995480835655 3.4615988243836386 0.015033707862590421 0.014344801369218748 1.9225561201222707e-07 6.7161209741253876 -0.09914664757258551 LLEDGEDFNLGDALDSS(ph)NSMQTIQK ddPTM_A459_Selumetinib_30min_R2 2 LLEDGEDFNLGDALDSSNSMQTIQK 25 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 LLEDGEDFNLGDALDS(0.239)S(0.674)NS(0.088)MQTIQK;LLEDGEDFNLGDALDS(0.23)S(0.553)NS(0.216)MQT(0.001)IQK 140.69 1.3767e-08 14246300.0 77307.0 65217.0 69870.0 73414.0 72634.0 52554.0 47971.0 60252.0 49378.0 64399.0 True False 73010.58642444079 70218.93419429337 65374.640268704046 63414.886553786186 63509.067563801276 59792.83646228728 50201.74655273316 60427.32334474444 59254.979736594454 62539.6335413036 1.167429073216775 1.1227909442084925 1.045331361360282 1.0139951733472268 1.015501114534952 0.9560790985895012 0.8027189113536775 0.966224455166273 0.9474788447146907 1.0 15.932483145187636 -5.529323503326258 0.7455582221654983 0.9269811887759686 1.2008201902828974 0.6975820924382723 0.05223084822876939 0.7014695766219964 0.576051672500087 0.025720654473641136 0.13687711642930495 2.955809881448887e-06 5.529323503326258 0.27383900150692886 LLEDGEDFNLGDALDSSNSMQTIQK ddPTM_A459_Selumetinib_30min_R1 2 LLEDGEDFNLGDALDSSNSMQTIQK 25 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 259.16 5.8665999999999994e-61 40990000.0 5288.3 7163.4 5733.4 6603.9 6528.6 5319.5 6335.9 6160.0 3098.2 6103.7 False True 5411.507100759467 6324.705797825687 4954.8357713118785 5450.652835556078 5938.089282717949 5265.990659719556 5857.977961937646 5996.6167895000335 5257.419116424989 6887.169350072737 0.7857374816407433 0.9183316797283183 0.7194299311457397 0.7914213457664595 0.862195915460571 0.7646088533693368 0.8505639493060786 0.8706939650666063 0.7633642864276982 1.0 12.74969543686333 -11.041510346796958 3.343700663671815 1.0045097524492805 0.8163614077035372 0.48450042884902456 0.057500559674775895 148654193.7196911 179822776.30683038 6062034.704148434 0.013837524141925526 9.088446461470485e-12 11.041510346796958 -0.18814834474574338 LLEDGEDFNLGDALDSSNSMQTIQK ddPTM_A459_Selumetinib_30min_R2 1 LLEDGEDFNLGDALDSSNSMQTIQK 25 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 0 193.51 6.582300000000002e-27 2955300.0 54222.0 45851.0 60226.0 61701.0 59726.0 42263.0 49404.0 48933.0 46809.0 45207.0 False True 51208.55830786378 49367.624265798004 56351.12472911081 53297.21735983821 52222.68592278542 48084.34462468407 51701.383892168786 49075.38692870575 56172.10795273705 43901.75644810804 1.1664352966923406 1.1245022582217326 1.2835733530552005 1.2140110481191253 1.1895352292911727 1.0952715452631117 1.177660942866373 1.117845637604795 1.2794956853066366 1.0 15.421991040683274 -6.553873972810405 22.668195729995603 1.1439518222857288 1.1985742573340894 0.13609441889497298 0.07567336891602533 167.9487846589329 122825.87569410399 0.024222286709246147 0.02422279895718282 2.793354322456106e-07 6.553873972810405 0.05462243504836062 LLEDS(ph)EESSEETVSR ddPTM_A459_Selumetinib_30min_R2 1 LLEDSEESSEETVSR 15 0 A2AB15;A0A140T947;O60231 A2AB15 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 1 LLEDS(1)EESSEETVSR 242.01 2.9867e-20 5586500.0 11493.0 9587.8 13281.0 12053.0 13586.0 8097.1 9567.8 9049.7 8212.9 9501.8 True False 10854.265070124273 10323.153430363958 12426.514919259458 10411.36060741527 11879.205219618969 9212.402026844513 10012.721658236034 9076.033128741521 9855.709487599272 9227.458345358747 1.1763006305613704 1.1187428914871587 1.3466888122567122 1.1283020976899891 1.2873756537296106 0.9983683135755571 1.0851007160896327 0.9835897155045527 1.0680849610723546 1.0 13.171717604526089 -6.7707261312477485 24.99986774298974 1.0296325704298606 1.2092202286443832 0.6326501487458409 0.07025261706359476 128.27806165364203 345321.6064397113 0.023467813634900882 0.02097290789595868 1.6954065971699976e-07 6.7707261312477485 0.1795876582145226 LLEENETEAVTVPTPS(ph)PTPVR ddPTM_A459_Selumetinib_30min_R1 2 LLEENETEAVTVPTPSPTPVR 21 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 LLEENETEAVTVPT(0.072)PS(0.704)PT(0.224)PVR;LLEENETEAVTVPT(0.001)PS(0.757)PT(0.242)PVR 202.44 4.6953e-17 118997000.0 6046.1 7077.200000000001 7749.2 8066.900000000001 7595.700000000001 6253.0 7475.0 6673.9 3913.9 5452.0 True False 6186.962366337352 6248.598133898983 6696.901203308691 6658.167349467337 6908.670276129756 6190.100497269742 6911.154731842976 6496.886492117577 6641.60244005415 6151.817306977172 1.0057129556367548 1.0157320710437947 1.088605345238927 1.0823090181686443 1.1230291686806415 1.0062230700916868 1.1234330258807572 1.056092235500726 1.0796163326439296 1.0 12.58679694429608 -5.214011611270699 6.825030061443147 1.0738761813758277 1.0098702187687014 0.2602398740594839 0.039483895057023856 0.28395214986413797 33.11094949460767 0.009375597548421759 0.024967673035956955 6.10925691015322e-06 5.214011611270699 -0.06400596260712632 LLEENETEAVTVPTPS(ph)PTPVR ddPTM_A459_Selumetinib_30min_R2 6 LLEENETEAVTVPTPSPTPVR 21 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 LLEENETEAVTVPT(0.002)PS(0.986)PT(0.012)PVR;LLEENETEAVTVPT(0.063)PS(0.936)PT(0.001)PVR;LLEENETEAVTVPTPS(0.978)PT(0.022)PVR;LLEENETEAVTVPT(0.034)PS(0.953)PT(0.013)PVR;LLEENETEAVTVPT(0.001)PS(0.957)PT(0.042)PVR;LLEENETEAVTVPT(0.018)PS(0.872)PT(0.109)PVR 317.34 3.561399999999998e-136 871781200.0 217747.0 196768.5 255707.7 232912.3 233262.1 160125.5 190057.2 181732.59999999998 158824.5 189653.80000000002 True False 205645.49345030438 211860.011239551 239255.74497549303 201189.2429438717 203957.6296083676 182181.33415043537 198895.23639119708 182261.41177854838 190593.8379273106 184178.0020142497 1.1165583902598408 1.1503003014614066 1.2990462615452958 1.0923630441397982 1.107394082777527 0.9891590317954483 1.0799076665833778 0.9895938156851488 1.0348349740082667 1.0 17.490741232499325 -6.326375735310445 1.8919500439177679 1.0229551300735438 1.1814245404551447 0.6040922045516071 0.05616523047089996 0.23331674907779282 1.645416117007267 0.019754275734869806 0.02470902759098846 4.716548066310899e-07 6.326375735310445 0.1584694103816009 LLEENETEAVTVPTPSPT(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 LLEENETEAVTVPTPSPTPVR 21 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 LLEENETEAVTVPTPS(0.25)PT(0.75)PVR 161.56 1.0435e-07 23449000.0 25926.0 27278.0 24719.0 31342.0 26005.0 20847.0 22918.0 22409.0 20345.0 21859.0 True False 24485.136710001032 29370.13488740565 23128.606452012256 27073.165532034294 22738.01941235031 23718.485019775893 23983.732411155484 22474.206479990353 24414.56848679602 21227.87387349734 1.1534427261022278 1.3835646029569542 1.089539470125077 1.2753592608176698 1.071139745216706 1.1173273951560472 1.1298226357515149 1.0587120789354716 1.150118407160748 1.0 14.373672261590412 -2.807532877374377 0.1364174758246473 0.9666941177707514 1.749429887314536 0.37191938109811096 0.08385622861315038 53.08100946251158 0.677756471086992 0.40579067496852256 7.658214053990331 0.0015576401124132444 2.807532877374377 0.7827357695437845 LLEGEEER ddPTM_A459_Selumetinib_30min_R1 4 LLEGEEER 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5;Q03252;P20700;E9PBF6 P02545;P02545-2;Q03252;P20700 LMNA;LMNB2;LMNB1 Prelamin-A/C;Lamin-A/C;Lamin-B2;Lamin-B1 0 ;;; 191.63 0.011503 52815000.0 10317.4 11282.1 12810.800000000001 12093.099999999999 12477.8 10842.0 10903.300000000001 9991.2 6077.3 8944.4 False True 10557.77534583434 9961.186487094 11071.163724687322 9981.26710060164 11349.185193134515 10732.939323748362 10080.85530270281 9726.200920008563 10312.73423156981 10092.500865833934 1.0461010096690202 0.986988915781571 1.0969693113593328 0.9889785726341771 1.1245166430012234 1.0634568643023357 0.99884611720267 0.9637057305523349 1.0218214859392711 1.0 13.30099609013644 -7.3099898214403245 6.773196327531572 0.9926598017529903 1.0508171370474393 0.29369990437354 0.04172950749508668 0.30718206311258967 34.96035731611635 0.017319570764174896 0.011697391152470748 4.897902984490436e-08 7.3099898214403245 0.058157335294449 LLEGEESRIS(ph)LPLPNFSSLNLR ddPTM_A459_Selumetinib_30min_R1 2 LLEGEESRISLPLPNFSSLNLR 22 1 P08670;B0YJC4 P08670 VIM Vimentin 1 LLEGEES(0.004)RIS(0.996)LPLPNFSSLNLR;LLEGEES(0.013)RIS(0.97)LPLPNFS(0.006)S(0.011)LNLR 124.88 1.7577e-05 54108000.0 2808.8 3241.6000000000004 4029.9 3929.6 3505.2 3299.1000000000004 2887.8 3261.0 1732.0900000000001 2701.3 True False 2874.2395750266046 2862.0719650210444 3482.661714656183 3243.3691277277303 3188.155278893322 3265.91404934313 2669.9709210188803 3174.507686779156 2939.230223151689 3048.0381678902118 0.9429801783014066 0.9389882302563524 1.142591241587637 1.0640841580972467 1.0459696051313216 1.0714806933023833 0.8759637425626393 1.0414921047319048 0.9643023024170865 1.0 11.573665253202366 LLELTSS(ph)YSPDVSDYK ddPTM_A459_Selumetinib_30min_R1 2 LLELTSSYSPDVSDYK 16 0 P38432 P38432 COIL Coilin 1 LLELTS(0.005)S(0.993)YS(0.003)PDVSDYK;LLELTS(0.023)S(0.506)YS(0.471)PDVSDYK 325.08 5.9895e-118 23952000.0 3831.6 5817.700000000001 3445.8 3955.0 4165.8 4358.8 4749.700000000001 4064.0 2155.89 3918.1000000000004 True False 3920.8688250042496 5136.5609794246475 2977.8792864245424 3264.33349454478 3789.0041255317255 4314.95442947375 4391.42630499459 3956.209518267554 3658.3878700243595 4421.026300525909 0.8868684686489735 1.1618480936911912 0.6735719455164301 0.738365545157799 0.8570417518396123 0.9760074100804282 0.9933047230395806 0.8948622444966992 0.827497422847082 1.0 12.110165601520327 -6.7423136094420855 24.076663685077204 0.9351988978967762 0.8626040209828055 0.07838797155208488 0.12798535361530766 515.5557361209612 649009.5380257814 0.04533725343962193 0.045256994704259305 1.8100325735750347e-07 6.7423136094420855 -0.07259487691397071 LLELTSS(ph)YSPDVSDYK ddPTM_A459_Selumetinib_30min_R2 1 LLELTSSYSPDVSDYK 16 0 P38432 P38432 COIL Coilin 1 LLELTS(0.168)S(0.686)Y(0.008)S(0.138)PDVS(0.001)DYK 95.073 0.016406999999999998 0.0 8087.4 7200.2 8081.7 7762.3 7530.5 5752.3 5536.1 7622.3 6436.2 7328.7 True False 7637.934684427312 7752.432187707984 7561.732220689651 6705.061349285616 6584.451266475835 6544.627110819637 5793.539619574036 7644.479631060302 7723.619842453509 7117.101388750625 1.0731805361800695 1.0892681956114283 1.062473584069185 0.9421056386640376 0.9251591212236061 0.9195635629364719 0.8140307834775788 1.0741001446379923 1.085219869800022 1.0 12.797074073110602 -5.70461315829443 5.531522503894156 0.9588868591221872 1.078934865847009 0.3103959928760577 0.0742594532206429 0.24746127829279918 15.471960982148143 0.022222015525322394 0.038508160016989396 1.9741804266466987e-06 5.70461315829443 0.12004800672482185 LLES(ph)PGVEAGEGEAEKEEAGAQGR ddPTM_A459_Selumetinib_30min_R2 1 LLESPGVEAGEGEAEKEEAGAQGR 24 1 A0A0G2JHC2;Q6NYC8;Q6NYC8-3 A0A0G2JHC2 PPP1R18 Phostensin 1 LLES(1)PGVEAGEGEAEKEEAGAQGR 105.52 3.4263000000000004e-07 3167700.0 11373.0 9136.7 9860.8 9854.1 10122.0 9794.4 11001.0 10358.0 8798.0 8982.0 True False 10740.934189726213 9837.455510879068 9226.366863627261 8511.95458072935 8850.383868171888 11143.489695289165 11512.568298067958 10388.140065140793 10557.845836659202 8722.666321961344 1.2313819872581173 1.127803718240486 1.0577461664901402 0.9758431959386688 1.014642030486594 1.2775324979740237 1.319845087858329 1.1909363125568877 1.2103920346095742 1.0 13.090553486348705 -6.76238582602387 24.999996487841255 1.2191812031979663 1.0768691295856336 0.2418073398379994 0.10166919202740926 32.48671239188058 858101.9353910072 0.03570732009302021 0.033319791909703064 1.728280277543147e-07 6.76238582602387 -0.14231207361233267 LLES(ph)PGVEAGEGEAEKEEAGAQGRPLR ddPTM_A459_Selumetinib_30min_R2 1 LLESPGVEAGEGEAEKEEAGAQGRPLR 27 2 A0A0G2JHC2;Q6NYC8;Q6NYC8-3 A0A0G2JHC2 PPP1R18 Phostensin 1 LLES(1)PGVEAGEGEAEKEEAGAQGRPLR 63.625 0.00070945 5940700.0 27324.0 30746.0 24420.0 34044.0 34814.0 19709.0 16745.0 14494.0 11181.0 22091.0 True False 25805.44146663845 33104.1193360281 22848.84378648566 29407.148470824315 30440.354078891112 22423.735849511366 17523.67567958803 14536.175140389127 13417.512423242384 21453.175430688956 1.2028728124659598 1.5430871501042391 1.065056492932985 1.3707597071507247 1.418920671079113 1.0452408745716038 0.8168336541228417 0.6775768551071931 0.6254324664706054 1.0 14.388903586204117 -7.0789231107840624 2.5249995039300157 0.7456607771305401 1.3204188476134675 0.7328871989266712 0.15283680851885878 0.1410275293238093 1.767978553909001 0.06337719337445608 0.04796656176815356 8.338287959064205e-08 7.0789231107840624 0.5747580704829274 LLESSLS(ph)SSEGEEPVEYK ddPTM_A459_Selumetinib_30min_R1 1 LLESSLSSSEGEEPVEYK 18 0 P08648 P08648 ITGA5 Integrin alpha-5;Integrin alpha-5 heavy chain;Integrin alpha-5 light chain 1 LLES(0.004)S(0.012)LS(0.328)S(0.328)S(0.328)EGEEPVEY(0.001)K 64.64 0.034919 2706400.0 821.65 651.89 765.79 822.34 665.73 948.42 896.17 1000.4 319.21 586.93 True False 840.7928463474117 575.5664157445609 661.7999241833683 678.7337562336176 605.5148390441775 938.8797558964603 828.5711753893933 973.8661422428297 541.6760558240335 662.2681826823385 1.2695655148976162 0.8690835990540637 0.999292947311656 1.0248623956002079 0.9143045897082102 1.4176730521671466 1.251111252292824 1.4705011771793834 0.8179104326439491 1.0 9.371271738344003 -6.744088040098953 24.999711863636847 1.2245750689696675 1.006920335429516 0.14830214516895646 0.2027856303036992 374.9506113887568 540225.5518128244 0.0640918141945802 0.06394725195042564 1.8026522704740003e-07 6.744088040098953 -0.21765473354015152 LLESSLSS(ph)SEGEEPVEYK ddPTM_A459_Selumetinib_30min_R1 1 LLESSLSSSEGEEPVEYK 18 0 P08648 P08648 ITGA5 Integrin alpha-5;Integrin alpha-5 heavy chain;Integrin alpha-5 light chain 1 LLESS(0.001)LS(0.12)S(0.869)S(0.01)EGEEPVEYK 216.0 7.4068e-40 0.0 1125.4 540.39 958.9 767.23 940.24 870.01 756.5 1011.3 422.69 620.36 True False 1151.6196303527981 477.12088757950465 828.68664686067 633.2476831907951 855.1954580128549 861.2584893058768 699.436595938356 984.4770388346404 717.2740579438636 699.9892488181135 1.645196168794354 0.6816117367303746 1.1838562495921954 0.9046534418349893 1.2217265614533324 1.2303881677612276 0.999210483760014 1.4064173706908587 1.0246929637204205 1.0 9.451188953552464 LLEVQPQVANS(ph)PSSAAQK ddPTM_A459_Selumetinib_30min_R2 1 LLEVQPQVANSPSSAAQK 18 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1;H7BZ98 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 LLEVQPQVANS(0.991)PS(0.005)S(0.005)AAQK 259.55 1.4587999999999997e-42 4203400.0 20813.0 15933.0 19822.0 20362.0 23128.0 16106.0 21280.0 18859.0 14229.0 17385.0 True False 19656.29678104034 17155.00986733025 18546.67410056179 17588.66047359078 20222.45387305665 18324.4553042889 22269.562165520056 18913.87656772447 17075.197591478023 16883.04987834535 1.1642621992281161 1.0161084632779367 1.0985381334654616 1.041794024203557 1.1977962523817753 1.0853758909871096 1.3190485324623478 1.1202879043782197 1.0113811020234635 1.0 14.043287926184123 -3.6778829359387646 12.370056190091667 1.1123000669284693 1.1406235608284199 0.0 0.09526414105727905 0.0 0.0 0.021705492118239866 0.0 0.000209950572904846 3.6778829359387646 0.02832349389995059 LLEVQPQVANSPS(ph)SAAQK ddPTM_A459_Selumetinib_30min_R2 1 LLEVQPQVANSPSSAAQK 18 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1;H7BZ98 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 LLEVQPQVANS(0.137)PS(0.431)S(0.431)AAQK 125.96 0.00080015 4544700.0 23115.0 23090.0 21896.0 27820.0 24610.0 21217.0 25353.0 21863.0 20934.0 24964.0 True False 21830.36083667647 24860.928753948116 20487.235198562255 24030.868007823174 21518.271783808545 24139.449161250326 26531.964736016424 21926.617710385523 25121.384944831054 24243.22445573849 0.9004726609916411 1.0254794612547264 0.8450705571763506 0.9912405856612423 0.8875994124913141 0.9957194103994859 1.0944074202858842 0.9044431259718583 1.0362229244998264 1.0 14.565293975923339 -6.899917191556901 7.985864405057289 1.0069909266025983 0.9341744485535612 0.2575551036625384 0.06473576895911949 0.3597392995923146 25.479483461991446 0.02170053544715871 0.019140399652113498 1.2591654783783091e-07 6.899917191556901 -0.07281647804903701 LLGHS(ph)PVLR ddPTM_A459_Selumetinib_30min_R2 4 LLGHSPVLR 9 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4 G8JLH2 CDC25B M-phase inducer phosphatase 2 1 LLGHS(1)PVLR;LLGHS(1)PVLR;LLGHS(1)PVLR;LLGHS(1)PVLR 98.754 0.012844 17667600.0 80547.0 89329.0 93722.0 99788.0 112480.0 82374.0 88463.0 77841.0 72623.0 100546.0 True False 76070.52019518848 96180.24706199362 87692.02855679793 86196.70225609833 98349.25681604154 93720.27078327913 92576.70478610897 78067.50442272869 87149.62925616054 97642.97573011849 0.7790680243650556 0.9850196221777612 0.8980884482584328 0.8827742252995523 1.00723330153185 0.9598260405573713 0.9481143327912035 0.799519922851433 0.8925335243473 1.0 16.575228642362774 -4.746237524323631 24.67031788425155 0.9254651371673245 0.7790675580907684 0.35519514208529335 0.06082809192095839 881.8754594114462 1431056.36822525 0.015740537876968164 0.3606210306118648 1.7937523195496277e-05 4.746237524323631 -0.14639757907655604 LLGLNELDDLLGKESPS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 LLGLNELDDLLGKESPSK 18 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 LLGLNELDDLLGKES(0.36)PS(0.64)K 108.77 0.00082266 1965200.0 456.56 320.08 489.85 497.67 429.83 293.97 465.96 275.74 198.52 388.11 True False 467.19695968888703 282.60488479884486 423.3310605534458 410.7612769229083 390.95195239264984 291.01292870340416 430.812262053452 268.4264794702498 336.87394067287084 437.92769901153895 1.0668358287073705 0.6453231559381187 0.9666688394202063 0.9379659652724665 0.8927317300894198 0.6645227725039066 0.983752028076444 0.6129470231641525 0.7692455659535584 1.0 8.774548893191186 -6.605974415332853 24.999672362442396 0.791407582320937 0.8933452585778178 0.08621661960162053 0.15097271738855247 65.13460525658522 19589.041990841233 0.047458027526027326 0.047458029415039134 2.477568009028959e-07 6.605974415332853 0.10193767625688077 LLGLTPPEGGAGDRS(ph)EEEASSTEKPTK ddPTM_A459_Selumetinib_30min_R1 1 LLGLTPPEGGAGDRSEEEASSTEKPTK 27 2 V9GYY5;Q9UGY1 V9GYY5 NOL12 Nucleolar protein 12 1 LLGLTPPEGGAGDRS(0.982)EEEAS(0.011)S(0.004)T(0.004)EKPTK 86.825 5.9528e-05 31642000.0 1489.4 1451.8 1303.4 1366.2 1492.3 1107.4 1239.9 1563.6 636.02 1051.9 True False 1524.1001221320926 1281.8225810764911 1126.4054390637164 1127.6188167502105 1357.3217284869638 1096.260561438751 1146.3733447507836 1522.1282487114051 1079.2794869371326 1186.921611373676 1.284078162809914 1.0799555495438171 0.9490141794284784 0.9500364690850716 1.143564760705702 0.9236166490978297 0.9658374519139777 1.282416828647833 0.9093098285471739 1.0 10.213008941952905 -4.796037032690415 3.532147421292523 1.0222657628486227 1.3107910488296652 0.3510532253254115 0.10926949768504704 0.30987015591919687 6.473250941868953 0.02715666753444957 0.23430991544601326 1.599421638643663e-05 4.796037032690415 0.28852528598104255 LLGLTPPEGGAGDRS(ph)EEEASSTEKPTK ddPTM_A459_Selumetinib_30min_R2 1 LLGLTPPEGGAGDRSEEEASSTEKPTK 27 2 V9GYY5;Q9UGY1 V9GYY5 NOL12 Nucleolar protein 12 1 LLGLT(0.003)PPEGGAGDRS(0.868)EEEAS(0.081)S(0.02)T(0.02)EKPT(0.006)K 45.913 0.020804 15290000.0 45415.0 47933.0 49469.0 45944.0 48174.0 34553.0 40592.0 37863.0 32631.0 47158.0 True False 42891.016110649434 51609.30697111285 46286.21839777475 39686.34794217932 42121.951438975746 39312.36210909566 42479.60843152206 37973.17506144292 39158.111786318084 45796.42600880128 0.9365581519921777 1.1269287031523907 1.0106949915453955 0.8665817706943396 0.919765036487359 0.858415503898503 0.9275747505571332 0.82917333012286 0.8550473300862511 1.0 15.482947393143075 -5.6859811276154835 5.135455775632303 0.88774395833013 1.0394825707974478 0.47426917026547655 0.06286925544538889 0.1486953913867541 6.998913024963624 0.01622454848961025 0.028364562716150836 2.060719460447476e-06 5.6859811276154835 0.1517386124673178 LLGPAPEDDGGHNDHSQPQASQDQDS(ph)HTLSPQV ddPTM_A459_Selumetinib_30min_R1 1 LLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV 33 0 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 LLGPAPEDDGGHNDHS(0.011)QPQAS(0.063)QDQDS(0.6)HT(0.172)LS(0.155)PQV 40.777 0.028644 5346900.0 902.12 1281.5 1302.9 1297.5 2023.2 881.06 1475.8 1143.4 305.95 1063.6 True False 923.1376407800484 1131.4613842468134 1125.9733363174116 1070.915982091493 1840.201917224973 872.1973363384743 1364.4792178266034 1113.0733177133664 519.1748042961157 1200.1234203413264 0.7692022546460258 0.9427875209076539 0.9382146179575216 0.8923382078377526 1.5333438928319574 0.7267563665163814 1.1369490793193024 0.9274657079825989 0.43260117709265056 1.0 10.228967064461173 -8.020954952772094 24.167417293205197 0.7042114205536555 0.9970225562300363 0.16097969910533516 0.247141163028983 824.5752874274275 950977.5290921365 0.15604510622354653 0.06050854878652035 9.528949980033532e-09 8.020954952772094 0.29281113567638084 LLGPAPEDDGGHNDHSQPQASQDQDS(ph)HTLSPQV ddPTM_A459_Selumetinib_30min_R2 2 LLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV 33 0 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 LLGPAPEDDGGHNDHS(0.004)QPQAS(0.09)QDQDS(0.442)HT(0.154)LS(0.31)PQV;LLGPAPEDDGGHNDHS(0.001)QPQAS(0.011)QDQDS(0.627)HT(0.181)LS(0.181)PQV 66.437 8.775200000000001e-05 23244000.0 67550.0 56248.0 77685.0 91418.0 99360.0 80968.0 68231.0 71098.0 69690.0 75266.0 True False 63795.841424075064 60562.04073417383 72686.8316770326 78966.71069515379 86877.50851032982 92120.60704567646 71403.87669716151 71304.88340909255 83629.9473012936 73092.87501544681 0.8728052003781901 0.8285628485864754 0.9944448301106175 1.0803612620035214 1.1885906593764424 1.2603226651873864 0.976892435576951 0.9755380862228171 1.144160046839312 1.0 16.157443160817934 -5.482561588785171 2.6795722635047894 1.0949191606937063 0.8494167284869059 0.5358489050392643 0.08803082349795566 0.2248320210670574 3.172440372837673 0.026852766136760128 0.06293358723388569 3.291837673477297e-06 5.482561588785171 -0.24550243220680046 LLGPAPEDDGGHNDHSQPQASQDQDSHTLS(ph)PQV ddPTM_A459_Selumetinib_30min_R1 1 LLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV 33 0 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 LLGPAPEDDGGHNDHSQPQAS(0.031)QDQDS(0.032)HT(0.055)LS(0.881)PQV 65.663 0.00012167 2776300.0 355.89 323.24 304.36 442.27 438.32 269.36 463.75 349.83 193.36 281.95 True False 364.1815445586079 285.39491052980077 263.02958372980856 365.0358469361112 398.6740333916813 266.65048295931206 428.7689641327331 340.5513719920124 328.1177975443601 318.1410289255711 1.1447173154261971 0.8970704328631839 0.8267703936776547 1.1474026099963082 1.2531361790652624 0.8381518217246188 1.3477323738493452 1.0704415370193705 1.031359578651275 1.0 8.313522630216879 -5.781992696479269 24.998027870937698 1.1072556117900267 0.9502744247518354 0.15500178431239886 0.15088078086526507 385.1393195002087 468425.3189494091 0.04159728752120101 0.061777502400529066 1.6519895794677678e-06 5.781992696479269 -0.1569811870381913 LLGPAPEDDGGHNDHSQPQASQDQDSHTLS(ph)PQV ddPTM_A459_Selumetinib_30min_R2 2 LLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV 33 0 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 LLGPAPEDDGGHNDHSQPQASQDQDS(0.028)HT(0.181)LS(0.791)PQV;LLGPAPEDDGGHNDHSQPQAS(0.028)QDQDS(0.279)HT(0.279)LS(0.414)PQV 118.5 8.756999999999997e-19 18907500.0 34777.2 34395.9 42493.0 48523.1 44013.6 31120.1 38784.7 41204.4 32683.0 37384.7 True False 32844.42244816202 37033.954929749845 39759.04664288026 41914.17007298364 38484.21808142364 35406.61129485912 40588.26540042505 41324.29798224437 39220.513239319436 36305.306573884234 0.9046727750754828 1.0200700234931979 1.0951304477202908 1.1544915613833178 1.060016336815808 0.9752461729748461 1.1179706007391688 1.138244016701693 1.0802969852217752 1.0 15.147892815051359 -4.847615401016417 2.600651501855567 1.082089287282749 0.8819401968934217 0.4907671340466492 0.05353066539256527 0.35566313478152334 3.5327244779222915 0.014561167562401995 0.1485853626486448 1.4203147557388557e-05 4.847615401016417 -0.20014909038932727 LLGPNASPDGLIPWT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LLGPNASPDGLIPWTR 16 0 A0A669KB68;A0A669KB56;A0A669KBA4;A0A669KB53;P42224;A0A669KB75;A0A669KB52;J3KPM9;A0A669KBI6;P42224-2 A0A669KB68 STAT1 Signal transducer and activator of transcription 1-alpha/beta;Signal transducer and activator of transcription 1 LLGPNASPDGLIPWT(1)R 130.47 0.0018336 11180000.0 1854.4 1792.7 2297.2 2470.4 1841.2 1629.0 1827.0 1457.6 977.14 1357.5 True False 1897.6039119657278 1582.8098505963806 1985.252857616362 2038.9910151513095 1674.6637850902623 1612.6137390136587 1689.1879190738614 1418.9397130479294 1658.135212518079 1531.748348169755 1.2388483488381912 1.0333354382184499 1.2960698537644826 1.3311527429343373 1.0933021648701453 1.0527928696254365 1.102784227639107 0.926353023160353 1.082511506866869 1.0 10.580963580182592 -6.474859237552221 5.903617774022818 1.036347630299053 1.2167898840354052 0.5263631319182167 0.0859215523941305 0.1858796910248967 15.725684345418696 0.02828125020743161 0.03151418453783854 3.3507402491953604e-07 6.474859237552221 0.18044225373635214 LLGPSLTST(ph)TPASSSSGSSSR ddPTM_A459_Selumetinib_30min_R2 1 LLGPSLTSTTPASSSSGSSSR 21 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 LLGPSLT(0.041)S(0.19)T(0.612)T(0.131)PAS(0.02)S(0.006)SSGSSSR 145.82 5.2632000000000015e-06 0.0 6570.5 7721.1 6518.0 7218.3 8222.5 9016.6 6439.7 7061.7 6136.0 8297.0 True False 6205.337913795492 8313.283542750494 6098.638976261818 6235.15508773796 7189.516039917341 10258.55480545457 6739.15881002347 7082.248377872629 7363.371454164679 8057.444051805087 0.770137263615914 1.0317519413477145 0.756894982708016 0.7738378383578245 0.8922824649718409 1.2731772928856235 0.8363891535199324 0.8789696003270432 0.9138594580144906 1.0 12.97610655039015 -6.531552014108203 24.99445175069152 0.9771113606590168 0.840789538708967 0.21706911151932184 0.1321338275508282 344.58629609104713 993014.2268951038 0.04477122478143537 0.044837459504040125 2.940681476321508e-07 6.531552014108203 -0.13632182195004983 LLGSLDEVVLLS(ph)PVPELR ddPTM_A459_Selumetinib_30min_R1 2 LLGSLDEVVLLSPVPELR 18 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 LLGS(0.124)LDEVVLLS(0.876)PVPELR;LLGSLDEVVLLS(1)PVPELR 210.98 1.0343e-11 52357000.0 2255.3 2512.0 2868.8999999999996 3456.5 2871.7 2316.8999999999996 2619.5 2538.4 1553.99 1894.65 True False 2307.8441019501197 2217.8938722028843 2479.319137739674 2852.887161540844 2611.9552420398136 2293.594089576885 2421.909006028452 2471.073386114754 2637.0075310610255 2137.846782953831 1.079518008657948 1.0374428560022686 1.1597272346683496 1.3344675513177107 1.2217691477547863 1.0728524176123886 1.1328730502763797 1.1558701988458262 1.2334876157109407 1.0 11.061942745113598 -10.590083316177774 4.984173317071439 0.9999964386902518 1.1587949029127682 0.24590000488892727 0.08335721796551715 3.62245085981532e-06 6.780750247360471e-07 0.0886279582257198 0.021494955218820094 2.569902718684137e-11 10.590083316177774 0.15879846422251642 LLGSLDEVVLLSPVPELRDS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 LLGSLDEVVLLSPVPELRDSSK 22 1 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 LLGSLDEVVLLSPVPELRDS(0.744)S(0.256)K 134.15 1.0574e-05 3135800.0 627.17 751.84 597.89 707.16 657.18 650.47 553.95 793.36 406.79 580.36 True False 641.7818407396163 663.8142232790667 516.6998219746854 583.6677810372407 597.7381850345527 643.9268623795052 512.1651055122966 772.3175156035304 690.2929192339168 654.8548591851189 0.9800367695801017 1.0136814501233091 0.7890295303262324 0.8912933497409469 0.9127796436883121 0.9833123376083486 0.7821047646338288 1.17937204675335 1.054115899961246 1.0 9.355031375604986 -7.768474963661844 24.999970828882297 1.0875579680590177 0.9094926842571531 0.46568173010345126 0.08341274626594118 142.411318126554 506028.6713299661 0.0439242775034327 0.021811026445408506 1.7042175617273517e-08 7.768474963661844 -0.1780652838018646 LLHEDLDES(ph)DDDMDEK ddPTM_A459_Selumetinib_30min_R1 1 LLHEDLDESDDDMDEK 16 0 O43150;O43150-2 O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 1 LLHEDLDES(1)DDDMDEK 155.28 6.1012e-05 5662200.0 1323.2 2190.8 1394.8 1517.8 1292.6 1156.4 1304.2 1422.4 876.75 1395.6 True False 1354.0279855009971 1934.3001175247107 1205.393821087978 1252.7447226346574 1175.6845582270657 1144.7676659271908 1205.8231439825556 1384.673331393644 1487.7807147135782 1574.738854295183 0.859842876047552 1.2283307243285484 0.7654563280763683 0.7955253782033321 0.7465901759014355 0.726957147723114 0.7657289592452803 0.8793034652170261 0.9447793268424018 1.0 10.620896884797881 -2.2452146630477494 11.396903049419395 0.8623732033760296 1.095684694830628 0.0 0.14659286740813396 0.0 0.0 0.035318685882606074 0.0 0.0056857182773239895 2.2452146630477494 0.2333114914545984 LLHEDLDES(ph)DDDMDEK ddPTM_A459_Selumetinib_30min_R2 6 LLHEDLDESDDDMDEK 16 0 O43150;O43150-2 O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 1 LLHEDLDES(1)DDDMDEK;LLHEDLDES(1)DDDMDEK;LLHEDLDES(1)DDDMDEK;LLHEDLDES(1)DDDMDEK;LLHEDLDES(1)DDDMDEK;LLHEDLDES(1)DDDMDEK 213.69 1.2453e-08 22596200.0 174161.0 167254.0 155193.0 153975.0 145782.0 117672.0 154367.0 141139.0 115755.4 149045.0 True False 164481.82884172248 180081.84399362674 145208.05134136215 133003.33937830958 127467.56185238417 133880.2498799382 161545.3713724074 141549.69112318082 138909.71447611065 144741.6835845838 1.1363818961356973 1.2441602137948806 1.003222069449716 0.9189014255218705 0.8806555146769104 0.9249598772402117 1.1160943231533154 0.977946971581703 0.9597077430354395 1.0 17.143120932178384 -5.351436726120659 5.204033599230466 0.9680064497520204 1.1891620645678624 0.6489054099275934 0.06426669356261258 0.13043868134913592 5.671771472948042 0.018243212525153065 0.039420312448174843 4.452083221500445e-06 5.351436726120659 0.221155614815842 LLHIEELR ddPTM_A459_Selumetinib_30min_R1 2 LLHIEELR 8 0 Q9Y224 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 ; 180.93 0.00063672 11152100.0 8459.4 10503.2 10070.099999999999 11829.6 10028.5 8701.0 9226.6 8631.4 5063.4 8041.700000000001 False True 8656.487560872987 9273.480461194795 8702.63573109983 9763.782429094044 9121.423945675479 8613.475839875906 8530.63013362172 8402.467233261455 8592.219983895908 9073.93052779133 0.9539953534314801 1.0219915650436477 0.9590811506045467 1.0760256979254865 1.0052340513009976 0.9492552112334166 0.9401251318262127 0.926000833654904 0.9469126920886097 1.0 13.147511898770558 -6.765221837936164 7.23937543150695 0.9469066457635181 1.0060015962641695 0.3191414920876934 0.03656321780218928 0.14169901059782525 42.64508998233999 0.01232951284507266 0.011488988523397454 1.7170311023860867e-07 6.765221837936164 0.05909495050065139 LLHMDS(ph)DDEIPIR ddPTM_A459_Selumetinib_30min_R2 1 LLHMDSDDEIPIR 13 0 Q1MSJ5;Q1MSJ5-1;Q1MSJ5-2 Q1MSJ5 CSPP1 Centrosome and spindle pole-associated protein 1 1 LLHMDS(1)DDEIPIR 103.77 0.0067419 0.0 6206.3 3951.3 5429.5 5838.2 4963.8 5390.7 3580.7 5242.4 3413.9 5859.4 True False 5861.378691787379 4254.352004568002 5080.171881192626 5043.027088543253 4340.203067064969 6133.219993097612 3747.2096450224426 5257.654516073959 4096.775392335855 5690.223897450488 1.030078745128742 0.7476598603570185 0.8927894530598002 0.8862616268584418 0.7627473268687376 1.077852137917738 0.6585346574326161 0.9239802529439408 0.7199673450760734 1.0 12.474269705100172 -7.279457798354645 24.998430203251683 0.8192856268809241 0.8855284676824956 0.06432808767805998 0.1308980758046876 2727.3436107434586 3783851.7685036855 0.05082578625125983 0.03434734541503244 5.254630733892082e-08 7.279457798354645 0.0662428408015715 LLHPS(ph)PDLVSQEATLSEAR ddPTM_A459_Selumetinib_30min_R1 4 LLHPSPDLVSQEATLSEAR 19 0 A0A087WU05;A0A087WY48;Q8IY22-3;Q8IY22-2;Q8IY22 A0A087WU05 CMIP C-Maf-inducing protein 1 LLHPS(1)PDLVSQEATLSEAR;LLHPS(1)PDLVSQEATLSEAR;LLHPS(1)PDLVSQEATLSEAR;LLHPS(1)PDLVSQEATLSEAR 269.39 8.3687e-59 77741000.0 16331.6 19138.5 17255.1 19874.0 17924.399999999998 16576.3 16697.399999999998 14500.5 9032.4 12406.8 True False 16712.094504238285 16897.75552275274 14911.952195479766 16403.378981184072 16303.141184809838 16409.557472076187 15437.90167484613 14115.89963573787 15327.323099605283 13999.333632465947 1.1937778570746507 1.2070399896438675 1.0651901431149093 1.1717256986534623 1.164565515247177 1.172167040438316 1.1027597512958753 1.0083265394148186 1.0948609056690803 1.0 13.773070536147056 -7.520058380508982 3.72354344901338 1.0391803796210597 1.1599588060421298 0.6402086751111693 0.042906681026619854 0.15218277312960127 4.6435678090222074 0.020971495665946926 0.012275784026675528 3.019545787385753e-08 7.520058380508982 0.12077842642107006 LLHPS(ph)PDLVSQEATLSEAR ddPTM_A459_Selumetinib_30min_R2 2 LLHPSPDLVSQEATLSEAR 19 0 A0A087WU05;A0A087WY48;Q8IY22-3;Q8IY22-2;Q8IY22 A0A087WU05 CMIP C-Maf-inducing protein 1 LLHPS(1)PDLVSQEATLSEAR;LLHPS(1)PDLVSQEATLSEAR 156.11 2.1925e-06 28464200.0 112469.0 112794.0 111169.0 119757.0 144202.0 109720.0 92796.0 92169.0 84740.0 119682.0 True False 106218.4232290793 121444.93711012694 104016.5075716552 103445.89000765231 126086.0555777634 124832.93406100683 97111.19787178563 92437.19653060075 101690.36783342806 116226.46968881984 0.9138918485045989 1.0448991304242383 0.8949468038575454 0.8900372719279374 1.084830812768737 1.0740490904974538 0.8355342645422107 0.7953196615029988 0.8749329486277079 1.0 16.82657914335126 -7.2828426919207585 24.832710234912803 0.8593900112381027 0.9828490456054428 0.27921918620034736 0.0826745022997744 919.294463003314 1066585.9805845565 0.03554689339948481 0.0239907830238969 5.2138352996601787e-08 7.2828426919207585 0.12345903436734018 LLHQFS(ph)FSPER ddPTM_A459_Selumetinib_30min_R1 1 LLHQFSFSPER 11 0 Q9UJX6-2;Q9UJX6 Q9UJX6-2 ANAPC2 Anaphase-promoting complex subunit 2 1 LLHQFS(0.797)FS(0.203)PER 93.494 0.015558 10473000.0 4810.9 5646.3 6226.8 6091.6 5553.9 5148.3 5438.8 4619.4 2364.8 3429.2 True False 4922.984609618158 4985.228571106343 5381.234761364084 5027.81641349406 5051.550725620686 5096.512776282394 5028.546937196998 4496.878506074102 4012.8928818416566 3869.371223236631 1.2722957621781779 1.2883820867764468 1.3907258959926874 1.2993884854729494 1.3055223792653297 1.3171423681647403 1.2995772819622993 1.1621729336976299 1.0370917263619315 1.0 11.91788343066501 -8.034593874162312 1.8281302138254936 1.0024944841163312 1.315378573410789 0.939330461161206 0.02998282238830426 0.08078327351834777 0.4847219252820234 0.02720167797970539 0.008861089239314376 9.23434563466557e-09 8.034593874162312 0.31288408929445777 LLHQFSFS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 LLHQFSFSPER 11 0 Q9UJX6-2;Q9UJX6 Q9UJX6-2 ANAPC2 Anaphase-promoting complex subunit 2 1 LLHQFS(0.292)FS(0.708)PER 87.566 0.021084 14466000.0 4381.7 5084.2 5329.2 5636.6 5102.5 4355.1 4654.0 4273.3 2106.7 3500.8 True False 4483.785084695982 4488.939500419547 4605.523911200212 4652.273622086249 4640.979775919545 4311.2916481144175 4302.9450330431055 4159.958202365341 3574.916032719812 3950.1617806796894 1.1350889744886534 1.1363938364183028 1.1659076683202978 1.177742553441887 1.174883468980602 1.0914215385306547 1.0893085579656219 1.0531108428803524 0.9050049671901513 1.0 11.947696025396063 -7.7236342421609905 1.267340970064888 0.9566996870304214 1.1541025073408788 0.8275240803397211 0.034360956658986044 0.17950827096326047 0.5288534186387738 0.028249628942099824 0.01126088992726485 1.8895820635354713e-08 7.7236342421609905 0.19740282031045742 LLHS(ph)PMTK ddPTM_A459_Selumetinib_30min_R2 1 LLHSPMTK 8 0 A0A6I8PS19;A0A6I8PL80;Q9NVN8 A0A6I8PS19 GNL3L Guanine nucleotide-binding protein-like 3-like protein 1 LLHS(0.997)PMT(0.003)K 77.533 0.035164999999999995 23902000.0 107920.0 107270.0 114960.0 114580.0 113960.0 111250.0 100100.0 87481.0 72650.0 95198.0 True False 101922.23843798928 115497.26407258642 107563.59875898404 98974.00633847517 99643.32598467373 126573.67767304981 104754.84834438718 87735.5552267408 87182.03001060348 92449.38638589154 1.1024652777310737 1.2493026572452421 1.163486346031595 1.0705750487661359 1.0778148982920674 1.369113226395258 1.133104852715102 0.9490117636965723 0.9430244311919858 1.0 16.496376123614084 -7.7090520898255885 5.084368091553499 0.9587086021624358 1.1723190407988584 0.5486762015532137 0.08452683028462887 0.147962827972079 8.061311127309773 0.04381013724751509 0.02389434411299049 1.954105063903529e-08 7.7090520898255885 0.2136104386364226 LLIDGDGAGDDRR ddPTM_A459_Selumetinib_30min_R2 1 LLIDGDGAGDDRR 13 1 Q6I9Y2;H7C5E3 Q6I9Y2 THOC7 THO complex subunit 7 homolog 0 102.05 0.013015 1918200.0 8157.9 7704.8 9735.2 9889.5 9793.4 9464.0 9857.6 7075.6 7193.2 11075.0 False True 7704.51657666117 8295.733385163252 9108.84783088433 8542.533039660937 8563.06553789316 10767.580094361741 10315.997932463835 7096.188824571359 8632.040994800747 10755.235973694269 0.7163503056097782 0.7713204438706319 0.8469221738289365 0.7942673745657205 0.7961764445556717 1.0011477312722532 0.9591605388942888 0.6597892265616112 0.8025896424693475 1.0 13.392751557898876 -4.482796881942151 0.7606761947093248 0.8589067740082404 0.5635347442814361 0.19033812441043263 0.09997071773155335 8.08931929777785 2.6122792071834904 0.04150125600903777 2.258786512102304 3.2900546964176486e-05 4.482796881942151 -0.2953720297268043 LLIDPNCSGHS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 LLIDPNCSGHSPR 13 0 Q8WYQ5-3;Q8WYQ5;Q8WYQ5-2;C9JSD5 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 1 LLIDPNCS(0.003)GHS(0.997)PR;LLIDPNCS(0.001)GHS(0.999)PR;LLIDPNCS(0.006)GHS(0.994)PR;LLIDPNCS(0.001)GHS(0.999)PR 137.52 0.00068567 14329100.0 13695.2 15471.300000000001 16176.099999999999 17599.8 18964.8 14533.5 16444.5 14327.5 5796.9400000000005 11204.7 True False 14014.271513779666 13659.913003587757 13979.474468957016 14526.3253191629 17249.43718850739 14387.306185362198 15204.078125457087 13947.488157721058 9836.98378825405 12642.932388020372 1.1084668559217075 1.0804386659957947 1.1057145636721957 1.1489680458093021 1.364354143414691 1.1379722475613872 1.2025752933602247 1.1031845880103575 0.7780618836160939 1.0 13.626043498998278 -8.106978543960874 5.333540055479542 0.8933570260418061 1.1640392463408895 0.5911753417937207 0.09003825625016175 0.1579445360752225 6.395822012072666 0.06521571404375089 0.023801238051173873 7.816664213604367e-09 8.106978543960874 0.2706822202990834 LLIDPNCSGHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 LLIDPNCSGHSPR 13 0 Q8WYQ5-3;Q8WYQ5;Q8WYQ5-2;C9JSD5 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 1 LLIDPNCS(0.354)GHS(0.646)PR;LLIDPNCS(0.001)GHS(0.999)PR;LLIDPNCSGHS(1)PR;LLIDPNCSGHS(1)PR 148.97 0.00035196 30478100.0 152270.0 158064.0 192339.0 232536.0 238697.0 175860.0 158043.0 171182.0 160703.0 223456.0 True False 143807.44298510597 170187.00054413386 179964.11814286883 200864.19565302547 208709.7488817453 200083.11870186529 165392.31265626336 171680.11127929421 192848.09041698597 217004.24467158684 0.6626941477699824 0.7842565513024596 0.8293115114647902 0.9256233487829344 0.9617772647609064 0.922023986234325 0.7621616476054064 0.7911371113459741 0.8886834942276881 1.0 17.72736373695337 -4.899453796552628 1.5938768005507518 0.8813955758483344 0.6155839763288478 0.5115816790654266 0.06930249398690051 0.7599662239772177 2.2311115598841127 0.02138173353006684 0.29585916850625094 1.2605097330755899e-05 4.899453796552628 -0.26581159951948663 LLIHQS(ph)LAGGIIGVK ddPTM_A459_Selumetinib_30min_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 LLIHQS(1)LAGGIIGVK 71.263 0.032652 3871300.0 2227.7 1974.4 3573.0 3198.9 3141.1 2868.3 2938.7 2939.2 1729.8 2648.5 True False 2279.6010756503706 1743.2363301263426 3087.806225084129 2640.2721657899633 2856.9880596062476 2839.447506208028 2717.0314930390564 2861.2428681328724 2935.3442604066704 2988.460773574658 0.7628010699714213 0.5833224734086653 1.033243016735548 0.8834889817314859 0.9560065451984672 0.9501371178486684 0.9091742200748613 0.9574302910157949 0.9822261300406991 1.0 11.545186890788255 -5.262564130674795 24.99999999149458 0.9525484334429709 0.6730617625416029 0.8008402066352531 0.056958300002437824 35.838791214423196 796615.1922116108 0.013640211680062204 0.031217368473387345 5.463058729388913e-06 5.262564130674795 -0.27948667090136803 LLIVQDAS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 LLIVQDASER 10 0 C9JPX5;C9JKL2;O95772-2;O95772 C9JPX5 STARD3NL MLN64 N-terminal domain homolog 1 LLIVQDAS(1)ER 103.46 0.014196 1211900.0 17989.0 7169.1 12428.0 12122.0 10118.0 9262.1 16592.0 13378.0 10563.0 8813.3 True False 16989.243395672635 7718.94691771024 11628.396010583285 10470.962688383628 8846.886383932333 10537.870202027452 17363.56087642428 13416.92776515287 12675.895154879652 8558.837129296586 1.9849943560111778 0.9018686535450672 1.3586420485535016 1.2234095041418545 1.0336551858954957 1.2312268644482915 2.0287289749900075 1.5676110623985609 1.4810300702522459 1.0 13.063199078746173 LLKEGEEPTVYS(ph)DEEEPK ddPTM_A459_Selumetinib_30min_R1 1 LLKEGEEPTVYSDEEEPK 18 1 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 LLKEGEEPT(0.008)VY(0.101)S(0.891)DEEEPK 54.828 0.038384 4301900.0 1037.7 1397.0 1272.4 1539.5 1251.2 1522.8 1691.4 1490.1 895.55 1256.9 True False 1061.876390987292 1233.4385905523202 1099.615068792905 1270.655224994107 1138.0291809173013 1507.482014591774 1563.8163362460475 1450.5777074730518 1519.6829416159062 1418.2353582427747 0.7487307271079326 0.8696995060682863 0.7753403286710837 0.8959410140277966 0.8024261800434485 1.0629279589105562 1.1026493784386047 1.022804641727696 1.0715308519023439 1.0 10.469881254470616 -6.763587146055704 24.99997835391248 1.0565745673289997 0.8231885430992911 0.8584567557532548 0.04738009302820869 19.08711671173098 222171.51151865884 0.015362816004242684 0.014211540111816266 1.723506215485686e-07 6.763587146055704 -0.23338602422970856 LLKEGEEPTVYS(ph)DEEEPKDESAR ddPTM_A459_Selumetinib_30min_R1 5 LLKEGEEPTVYSDEEEPKDESAR 23 2 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 LLKEGEEPTVY(0.003)S(0.997)DEEEPKDESAR;LLKEGEEPT(0.002)VY(0.438)S(0.56)DEEEPKDESAR;LLKEGEEPTVY(0.003)S(0.997)DEEEPKDESAR;LLKEGEEPTVYS(1)DEEEPKDESAR;LLKEGEEPTVY(0.441)S(0.559)DEEEPKDESAR 155.47 2.5077e-09 621541000.0 6871.390000000001 9805.400000000001 17665.2 17518.9 10601.300000000001 13319.900000000001 10329.310000000001 10052.2 6882.18 8360.09 True False 7031.480017602551 8657.379209593208 15266.362867997814 14459.55298548181 9642.414286811532 13185.91389950156 9550.161830524814 9785.583001852641 11678.556805460508 9433.188985672547 0.7453979802887661 0.9177574225155813 1.6183671175447554 1.5328382594097796 1.022179699935702 1.3978214493029644 1.0124001379628809 1.0373568277615686 1.2380284995030104 1.0 13.203529855781454 -7.301781978088525 24.94705717126601 1.075059439730876 1.2179196623047595 0.05811068318077983 0.260983782699674 1779.9526035346908 1100680.528395984 0.11776940202207348 0.07940125067930057 4.9913499733322164e-08 7.301781978088525 0.14286022257388353 LLKEGEEPTVYS(ph)DEEEPKDESAR ddPTM_A459_Selumetinib_30min_R2 6 LLKEGEEPTVYSDEEEPKDESAR 23 2 O00264-2;O00264 O00264-2 PGRMC1 Membrane-associated progesterone receptor component 1 1 LLKEGEEPT(0.015)VY(0.439)S(0.545)DEEEPKDESAR;LLKEGEEPT(0.001)VY(0.059)S(0.94)DEEEPKDESAR;LLKEGEEPT(0.024)VY(0.208)S(0.768)DEEEPKDESAR;LLKEGEEPT(0.017)VY(0.433)S(0.55)DEEEPKDESAR;LLKEGEEPTVY(0.011)S(0.989)DEEEPKDESAR;LLKEGEEPTVY(0.012)S(0.988)DEEEPKDESAR 127.16 1.0536e-05 247153400.0 420223.0 212658.0 340696.0 383791.0 166755.0 144850.7 274056.0 174038.0 120261.4 274500.0 True False 396868.68794595264 228968.1847967561 318775.9902817582 331518.0037235966 145805.74609138517 164802.56910126415 286800.1470316618 174544.42176645814 144317.04038426984 266574.47176334815 1.4887722943638555 0.8589276508067994 1.1958233966407406 1.2436224726646072 0.5469606490332819 0.6182233730451423 1.07587251372768 0.6547679551304154 0.541376071870781 1.0 18.02417910323642 -6.252112204947852 24.94864586525133 0.7330232752419463 1.1725849128015307 0.5080300311146784 0.21986695910822812 570.8356966775922 1526889.9560479356 0.06464759856625653 0.0823050443117168 5.596130003954565e-07 6.252112204947852 0.43956163755958433 LLKPGEEPSEYT(ph)DEEDTKDHNKQD ddPTM_A459_Selumetinib_30min_R1 2 LLKPGEEPSEYTDEEDTKDHNKQD 24 3 U3KPU8;U3KQM0;O15173;O15173-2 U3KPU8 PGRMC2 Membrane-associated progesterone receptor component 2 1 LLKPGEEPS(0.015)EY(0.088)T(0.893)DEEDT(0.004)KDHNKQD;LLKPGEEPS(0.019)EY(0.441)T(0.538)DEEDT(0.002)KDHNKQD 107.21 6.3237e-07 114674000.0 5535.5 7307.799999999999 9753.6 7575.1 6518.3 8301.4 6824.7 7846.5 4421.5 7630.5 True False 5664.466379791995 6452.1993786959465 8429.114692689778 6252.250987237971 5928.720915899333 8217.895453068128 6309.907384402508 7638.385330975974 7502.962566416984 8609.94900236414 0.65789778525246 0.7493888032233742 0.9789970521747914 0.7261658559790788 0.6885895507942511 0.954465055578336 0.7328623413065419 0.8871580225247105 0.871429385279379 1.0 13.071788977074654 -14.522878589429315 0.06814139340174631 1.7006190658631513 0.5514176514220902 0.33953870980130996 0.09874246546077275 410.8280424807073 2.013692190824691 45.206682016026356 5.91320420054777 3.0000010765809195e-15 14.522878589429315 -1.1492014144410612 LLKPGEEPSEYT(ph)DEEDTKDHNKQD ddPTM_A459_Selumetinib_30min_R2 3 LLKPGEEPSEYTDEEDTKDHNKQD 24 3 U3KPU8;U3KQM0;O15173;O15173-2 U3KPU8 PGRMC2 Membrane-associated progesterone receptor component 2 1 LLKPGEEPS(0.016)EY(0.191)T(0.742)DEEDT(0.051)KDHNKQD;LLKPGEEPS(0.005)EY(0.188)T(0.784)DEEDT(0.022)KDHNKQD;LLKPGEEPS(0.163)EY(0.148)T(0.653)DEEDT(0.036)KDHNKQD 63.706 0.0018052 147863000.0 171463.0 62056.0 134338.0 120561.0 62490.0 61163.0 199932.0 112579.0 88056.0 88621.0 True False 161933.7728807725 66815.49565851042 125694.8393361551 104140.38382067496 54639.447532311926 69587.64806756614 209229.23415774226 112906.5862515432 105669.66049020931 86062.28146498946 1.8815881954819886 0.7763621242796275 1.4605101932754172 1.2100583675909145 0.6348826292100972 0.8085731273098393 2.431137434380678 1.3119171875251079 1.227827785778561 1.0 16.393093465415483 LLLAADPGGS(ph)PAQR ddPTM_A459_Selumetinib_30min_R1 2 LLLAADPGGSPAQR 14 0 Q5SQI0-7;Q5SQI0-6;Q5SQI0-5;Q5SQI0-4;Q5SQI0-3;Q5SQI0-2;Q5SQI0 Q5SQI0-7 ATAT1 Alpha-tubulin N-acetyltransferase 1 1 LLLAADPGGS(1)PAQR;LLLAADPGGS(1)PAQR 128.85 0.0011012 11262700.0 4359.7 5170.5 4091.7 4781.5 5087.7 3985.7999999999997 4165.2 3994.3999999999996 2520.97 4468.1 True False 4461.272527500529 4565.135456299762 3536.069614099282 3946.500784871271 4627.518433306392 3945.7064708168427 3851.015610578241 3888.455536360215 4277.901965636148 5041.624157979583 0.8848879622332599 0.9054890474281659 0.7013750932827075 0.7827836152016576 0.9178626347983974 0.7826260639781751 0.7638442473906117 0.7712704109856738 0.8485166350342357 1.0 12.299672857116896 -8.556326722365476 18.6950681079192 1.0000000025300149 0.8126307489150487 0.41789001417367666 0.06570941489975228 353.63150246069523 197656.38074073396 0.06626881929246929 0.017110535567819895 2.777622859067575e-09 8.556326722365476 -0.18736925361496615 LLLAADPGGS(ph)PAQR ddPTM_A459_Selumetinib_30min_R2 4 LLLAADPGGSPAQR 14 0 Q5SQI0-7;Q5SQI0-6;Q5SQI0-5;Q5SQI0-4;Q5SQI0-3;Q5SQI0-2;Q5SQI0 Q5SQI0-7 ATAT1 Alpha-tubulin N-acetyltransferase 1 1 LLLAADPGGS(1)PAQR;LLLAADPGGS(1)PAQR;LLLAADPGGS(1)PAQR;LLLAADPGGS(1)PAQR 149.32 0.00044237 26088000.0 96582.0 74354.0 98216.0 108539.0 108715.0 87727.0 78334.0 90824.0 72007.0 86671.0 True False 91214.35908837919 80056.71271420772 91896.88948949549 93755.80095978157 95057.24977556877 99810.59794358329 81976.68621587625 91088.28280327746 86410.41204368245 84168.58303169796 1.083710284798638 0.9511472075519948 1.0918193722577823 1.1139049462728041 1.1293673524213914 1.1858414903574477 0.9739582545307168 1.0822123828432937 1.026634985777772 1.0 16.360994209487252 -8.134199299275553 1.1580750040062626 1.0064692628998282 1.0819604092164519 0.14459293962997533 0.06503050666665428 1.051070944294261 2.667261217408104 0.06435094502733761 0.02170681408102303 7.341768744718659e-09 8.134199299275553 0.07549114631662368 LLLAEDS(ph)EEEVDFLSER ddPTM_A459_Selumetinib_30min_R1 4 LLLAEDSEEEVDFLSER 17 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 LLLAEDS(1)EEEVDFLSER;LLLAEDS(1)EEEVDFLSER;LLLAEDS(1)EEEVDFLSER;LLLAEDS(1)EEEVDFLSER 295.22 2.4370999999999998e-76 72013480.0 6342.250000000001 9710.09 8914.49 10206.56 8694.72 7376.0199999999995 8486.51 6526.98 3780.1400000000003 5838.069999999999 True False 6490.012085129766 8573.228148701633 7703.951221788479 8424.17589685992 7908.284111177491 7301.823935690312 7846.365718171606 6353.863287780994 6414.621489498022 6587.443152117425 0.9852095775648035 1.3014500392228676 1.1694903536757157 1.2788233161681415 1.2005088967842559 1.1084458365827812 1.191109439122753 0.9645416500844717 0.9737649861063542 1.0 12.685502891391119 -7.760691904752074 24.995836822315496 0.9768649423835125 1.1832242792217866 0.5398835828326316 0.08316514376096078 14.116398966195892 472115.9659609519 0.040369345198791505 0.021524269534280025 1.735034421616913e-08 7.760691904752074 0.20635933683827412 LLLAEDS(ph)EEEVDFLSER ddPTM_A459_Selumetinib_30min_R2 1 LLLAEDSEEEVDFLSER 17 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 LLLAEDS(1)EEEVDFLSER 119.96 0.0013584 0.0 4618.6 3784.3 4253.7 5371.2 4863.9 3460.8 4045.2 3721.6 3515.0 4727.5 True False 4361.916701720701 4074.5436415576396 3980.0215730783825 4639.633294163187 4252.853398182296 3937.4937859855354 4233.309815411734 3732.429239855954 4218.098217305876 4591.004791479877 0.9501006641978844 0.8875058569137847 0.8669173206842704 1.0105921263191788 0.9263447962578621 0.8576540354069883 0.9220878669671694 0.8129874416125 0.9187745186269349 1.0 12.164594222406256 -6.615869045309685 16.803259580622996 0.891851853156336 0.9272937002973892 0.03296347218215301 0.057802526074608195 4.584164290857142 816.6325080698402 0.018681973728357403 0.01868172916764172 2.4217591801527135e-07 6.615869045309685 0.03544184714105325 LLLAS(ph)PPNER ddPTM_A459_Selumetinib_30min_R1 3 LLLASPPNER 10 0 Q52LW3 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 LLLAS(1)PPNER;LLLAS(1)PPNER;LLLAS(1)PPNER 147.58 0.00081938 60057000.0 9750.7 11108.3 11440.8 11709.4 10353.1 8965.5 9657.6 9699.8 5125.2 7746.7 True False 9977.872338440586 9807.735071891435 9887.20219981598 9664.573102660594 9416.663932988258 8875.315210022682 8929.119456621633 9442.529794609163 8697.090070202486 8741.064404247985 1.1414939733874443 1.1220298373645512 1.1311210789170016 1.1056517439642477 1.0772903044178401 1.015358633636134 1.02151397629358 1.0802494247748913 0.9949692243402156 1.0 13.093593252858234 -6.3938961030701496 1.7741212579397423 1.0268515474924598 1.1299731953825412 0.8127243569262309 0.023239736823448306 0.15316445113000826 0.9579997844656164 0.008405410676528864 0.010085934383713165 4.0374196922084646e-07 6.3938961030701496 0.10312164789008138 LLLAS(ph)PPNER ddPTM_A459_Selumetinib_30min_R2 4 LLLASPPNER 10 0 Q52LW3 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 LLLAS(1)PPNER;LLLAS(1)PPNER;LLLAS(1)PPNER;LLLAS(1)PPNER 103.43 0.01423 34407900.0 52875.0 48556.1 57421.0 61526.0 59504.0 48350.0 44670.1 48157.0 41210.6 54834.0 True False 49936.41917539556 52280.19673753055 53726.59537525773 53146.052661730035 52028.57554749061 55009.77362239965 46747.348162123926 48297.128897179464 49453.871520371395 53250.799944158134 0.9377590426390171 0.98177298354869 1.0089349912414187 0.9980329444339251 0.9770477739686687 1.0330318733255852 0.8778712847721705 0.906974711137234 0.9286972509752264 1.0 15.700515577503916 -7.261676857137657 24.99999912993592 0.920633705150367 0.9897967050581327 0.3898878067964282 0.03690182756884519 20.02655763098583 2108120.0466500353 0.014363351824755361 0.010376348463177849 5.4742312920542736e-08 7.261676857137657 0.06916299990776564 LLLDGPPPHS(ph)PETPQFPPTTGAVLYTVK ddPTM_A459_Selumetinib_30min_R1 1 LLLDGPPPHSPETPQFPPTTGAVLYTVK 28 0 Q3T8J9-3;Q3T8J9 Q3T8J9-3 GON4L GON-4-like protein 1 LLLDGPPPHS(0.556)PET(0.444)PQFPPTTGAVLYTVK 75.794 6.5317e-05 33891000.0 654.17 1012.7 1030.0 1232.2 1213.1 990.5 1029.4 695.93 541.98 654.01 True False 669.410888206762 894.1326132085433 890.1316573850135 1017.0194012586803 1103.3753191902008 980.5364693020432 951.7515292253051 677.4716757007723 919.7004753469811 737.9585540968706 0.9071117673078556 1.211629851357712 1.2062081975245555 1.3781524661684157 1.4951724769157735 1.3287148226122871 1.2897086481910613 0.9180348570251029 1.2462765967562097 1.0 9.527395982377502 -7.73744098047127 24.98326617614371 1.061616762719486 1.271922077161963 0.24734047050475683 0.1625481885158613 318.6312086691904 331707.9826472105 0.08048172718508272 0.04643504435158286 1.8304548436226917e-08 7.73744098047127 0.21030531444247713 LLLDIPLQT(ph)PHK ddPTM_A459_Selumetinib_30min_R1 2 LLLDIPLQTPHK 12 0 P49792;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 LLLDIPLQT(1)PHK;LLLDIPLQT(1)PHK 120.21 0.0055432 16102100.0 7883.9 11609.5 7931.1 8389.4 7179.6 9888.0 9330.5 8787.5 5263.6 7583.9 True False 8067.579530601051 10250.25434288988 6854.100182413867 6924.348778542099 6530.2064476613305 9788.53569758567 8626.692872971353 8554.426954177197 8931.944761866427 8557.367438441695 0.9427641840362724 1.1978280022011607 0.8009589668457668 0.8091681031991574 0.763109273341018 1.1438723144706022 1.0081012571948507 0.9996563798053957 1.0437724950014466 1.0 13.062951323386063 -6.772132804854073 24.999978336906025 1.037122780927804 0.9083022428599593 0.24515015071821944 0.11937662478197984 373.67070556823944 873593.188815424 0.04556365837269909 0.04058233672156921 1.6899240831709547e-07 6.772132804854073 -0.12882053806784477 LLLDT(ph)SPPGGVVLSSFR ddPTM_A459_Selumetinib_30min_R1 1 LLLDTSPPGGVVLSSFR 17 0 A2AB89;O15211 A2AB89 RGL2 Ral guanine nucleotide dissociation stimulator-like 2 1 LLLDT(0.585)S(0.415)PPGGVVLSSFR 110.6 0.0049457 14015000.0 2670.7 2976.5 3477.6 3033.7 2916.1 2443.9 2998.2 3051.2 1713.1 2283.6 True False 2732.922113722425 2628.0099962626923 3005.361021089439 2503.921244601896 2652.339269879271 2419.31658488366 2772.0433601353316 2970.272264305601 2907.005580126411 2576.7223041476645 1.060619574458346 1.0199042372678158 1.1663503732054512 0.9717466412936376 1.0293461835642468 0.9389124241247753 1.0758021365644506 1.152732779750636 1.1281796161918964 1.0 11.331321349598685 -7.516951408595572 24.931760814081926 1.107127221401971 1.0317791786696426 0.14641219873373512 0.06731683297224766 429.81885926614336 1807939.3505593827 0.030626341427760044 0.018406151898659226 3.0412252766965936e-08 7.516951408595572 -0.07534804273232831 LLLERPS(ph)PIR ddPTM_A459_Selumetinib_30min_R1 2 LLLERPSPIR 10 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 LLLERPS(1)PIR;LLLERPS(1)PIR 132.56 0.011482 211286000.0 9362.2 13026.5 10309.5 10854.7 10924.1 8499.3 10549.8 9861.6 5306.9 8464.3 True False 9580.32104432999 11501.35132414444 8909.5265260299 8959.130412954552 9936.017083806497 8413.80475874696 9754.020092307286 9600.038333008692 9005.421699359556 9550.775354263917 1.0030935383746498 1.2042322112633184 0.9328589769470672 0.9380526795612225 1.0403361732689682 0.8809551525039944 1.0212804437864442 1.0051580083205267 0.9428995411706664 1.0 13.221402143919896 -5.27933351650488 24.95075021918482 0.9703716179813224 1.1036628914988 0.41006586875677964 0.06403499586926871 622.659942838762 868207.2919953421 0.01569937608337011 0.03278328240779297 5.256134664302961e-06 5.27933351650488 0.1332912735174776 LLLERPS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 2 LLLERPSPIR 10 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 LLLERPS(1)PIR;LLLERPS(1)PIR 103.46 0.0078068 138361000.0 72025.0 68857.0 68113.0 69268.0 75858.0 59943.0 58090.0 69413.0 60688.0 68546.0 True False 68022.13883891936 74138.1104898487 63730.683735827144 59833.578906035094 66328.03986087556 68199.60414162352 60791.30010315128 69614.98033805926 72827.29576439812 66566.89887610353 1.0218613152690854 1.113738385617707 0.9573930108182561 0.8988488260118485 0.996411744887312 1.0245272844775124 0.913236174878719 1.045789747057752 1.09404669579015 1.0 16.0225173391488 -7.968133661774602 24.99797289149387 1.0546551248650728 0.9902855300175804 0.15292519373330427 0.061127519455345 335.8527942719913 263464.011599554 0.0352961921226404 0.016955456760054364 1.0761339634807567e-08 7.968133661774602 -0.0643695948474925 LLLPGELAK ddPTM_A459_Selumetinib_30min_R1 1 LLLPGELAK 9 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;A0A2R8Y619;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 0 143.01 0.028676 101390000.0 14148.0 9818.6 9141.2 8985.6 27005.0 12514.0 8434.9 8268.3 14473.0 23112.0 False True 14477.620872784239 8669.033747456695 7899.875249017366 7416.433640602177 24562.402518119983 12388.120521802894 7798.648702023046 8048.997824776478 24559.623933903204 26078.650329944285 0.5551522294909795 0.33241880380222943 0.3029250037509224 0.2843871729085 0.9418586547754237 0.4750292045435528 0.29904341686994457 0.3086431898484554 0.9417521084556707 1.0 14.670581586055484 -8.273122284334894 22.760743262463283 0.9708767068301805 0.43780118334706764 0.5586523403381423 0.18965651831172337 195.5309793813909 380922.0397808589 0.18582606677411118 0.04998056717249558 5.331847454747617e-09 8.273122284334894 -0.5330755234831128 LLNGNHENGDLDPTS(ph)PLENMDYIK ddPTM_A459_Selumetinib_30min_R2 1 LLNGNHENGDLDPTSPLENMDYIK 24 0 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73;F8WE35;F5H8I0;F5H2W9;F5H2H9;F5GZ10;F5H502;F5H1K9;F5H6X8;F5H221;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 LLNGNHENGDLDPT(0.424)S(0.576)PLENMDYIK 84.573 0.0011413 0.0 2239.1 2274.3 3630.8 2546.7 2959.1 3337.2 2839.8 4077.0 2717.0 4071.9 True False 2114.659785827485 2448.731496972897 3397.198280916139 2199.835066697459 2587.3514033103556 3796.8690079146236 2971.856326956947 4088.8633950163144 3260.475919322918 3954.333666933246 0.5347701949156692 0.6192526233811706 0.859107644183909 0.5563099252581597 0.6543078104273776 0.9601792179715721 0.7515441480844351 1.0340208337015226 0.8245323217379265 1.0 11.949218895567324 -6.753387474577939 24.96200360364678 0.9060246628461386 0.6503285445168556 0.5904810304078159 0.1119892134364485 131.9469163651002 409052.90013352915 0.036603525943044495 0.03598642088037343 1.7644628764561582e-07 6.753387474577939 -0.25569611832928296 LLNLQDSDS(ph)EECTSR ddPTM_A459_Selumetinib_30min_R2 1 LLNLQDSDSEECTSR 15 0 Q52LR7 Q52LR7 EPC2 Enhancer of polycomb homolog 2 1 LLNLQDS(0.089)DS(0.678)EECT(0.018)S(0.215)R 118.5 0.002017 1923500.0 12775.0 16217.0 13621.0 16780.0 16489.0 12520.0 11892.0 11596.0 11007.0 13291.0 True False 12065.016642376899 17460.79175412631 12744.639689423479 14494.535052885443 14417.504406469698 14244.516354755799 12445.001563550954 11629.742440178861 13208.70756127618 12907.254295834808 0.9347469543751299 1.3527890094921997 0.987401301416692 1.1229758646316323 1.117007852795017 1.1036054631194898 0.9641865944771055 0.9010237323620252 1.0233553363505554 1.0 13.655894514580385 -7.25381369899446 6.203500816183224 0.9634126732173693 1.111106900164635 0.2624135793090313 0.10669363846396816 0.1873301342681295 34.556862554871124 0.04020599321752559 0.02930060175631594 5.574248183594043e-08 7.25381369899446 0.14769422694726564 LLPAAS(ph)SDAESGTGSSDREPPR ddPTM_A459_Selumetinib_30min_R1 1 LLPAASSDAESGTGSSDREPPR 22 1 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 LLPAAS(0.5)S(0.5)DAESGTGSSDREPPR 109.56 2.8157e-05 16087000.0 2383.2 2966.9 2930.5 3064.7 3225.8 2361.5 3009.3 2980.2 1612.8 2169.7 True False 2438.7239231000435 2619.5339687256114 2532.554196084256 2529.5076765439685 2934.0269595612463 2337.745454070446 2782.306078198672 2901.1554149461035 2736.8038057485714 2448.2021296677103 0.9961285032584489 1.0699827179225416 1.0344546985701686 1.033210308042373 1.1984414701736559 0.9548825343059986 1.1364691029724368 1.185014660264131 1.117883108009563 1.0 11.257506960107197 -5.760795390127791 0.755367805864566 1.1074270213188468 1.0127795243321231 0.1142708876652555 0.07445800902537043 2.0339570305451926 2.0221992076170485 0.03673902774457726 0.13178741485476184 1.7346210401300047e-06 5.760795390127791 -0.0946474969867237 LLPAAS(ph)SDAESGTGSSDREPPR ddPTM_A459_Selumetinib_30min_R2 2 LLPAASSDAESGTGSSDREPPR 22 1 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 LLPAAS(0.5)S(0.5)DAESGTGSSDREPPR;LLPAAS(0.601)S(0.397)DAESGTGS(0.001)S(0.001)DREPPR 80.585 0.00063576 17709700.0 35096.0 34391.0 40308.0 36565.0 37845.0 33540.0 27124.3 29823.0 29520.5 43069.0 True False 33145.50482041952 37028.679115505845 37714.627164032136 31584.78392185676 33090.57276140733 38159.830554194064 28385.63369578079 29909.77999253658 35425.42487168652 41825.48606329919 0.7924714794768126 0.885313778767955 0.9017140196997201 0.7551564104731735 0.7911581161621807 0.9123583285187056 0.6786683519426799 0.7151089636417078 0.84698178565273 1.0 15.35209468579124 -5.758473942406973 24.998890630506832 0.7998162357313684 0.8623811549592162 0.032715356336892376 0.09265300838070437 202.90617930867896 1710479.4276550135 0.025015111956859452 0.041033522698442515 1.7439179891014852e-06 5.758473942406973 0.06256491922784779 LLPAASS(ph)DAESGTGSSDREPPR ddPTM_A459_Selumetinib_30min_R2 1 LLPAASSDAESGTGSSDREPPR 22 1 Q9Y4B5 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 LLPAAS(0.286)S(0.71)DAES(0.001)GTGS(0.001)S(0.002)DREPPR 62.707 0.0057238 4513000.0 7435.1 7466.0 8927.6 8497.7 9777.3 6496.8 6946.3 7257.6 6915.0 7662.2 True False 7021.886907063522 8038.618193026278 8353.207935635932 7340.298600649857 8548.988163828977 7391.67522792153 7269.316713832323 7278.71841443964 8298.193221243278 7440.972377213563 0.9436786687404722 1.0803182414227046 1.1225962834126224 0.9864703466885593 1.1489073914598156 0.9933749049461605 0.9769310172542907 0.978194521555974 1.115202798851233 1.0 12.861275447946863 LLPDPGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 LLPDPGSPR 9 0 A6ND36 A6ND36 FAM83G Protein FAM83G 1 LLPDPGS(1)PR;LLPDPGS(1)PR;LLPDPGS(1)PR;LLPDPGS(1)PR 106.16 0.013330000000000002 55588000.0 27523.999999999996 28857.0 30373.300000000003 31281.199999999997 30191.2 23627.300000000003 25956.199999999997 25058.5 14839.3 21662.199999999997 True False 28165.255647618986 25478.40902474465 26248.77268859441 25818.525640848093 27460.411290689295 23389.630813871943 23998.302936543492 24393.867178520548 25181.208280409715 24442.754377696398 1.1522946723761749 1.042370619572779 1.0738876757909892 1.056285443198949 1.1234581367698258 0.9569146935099339 0.9818166384080487 0.9979999308416543 1.030211566638625 1.0 14.57711924666769 -6.762776835189999 24.999999941530387 0.9925403133438834 1.0843018563053326 0.6631123448836179 0.03420031443653053 23.07559803027989 431326.5805008702 0.011609606629862384 0.010805921542586699 1.726724951976277e-07 6.762776835189999 0.09176154296144923 LLPDPGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 LLPDPGSPR 9 0 A6ND36 A6ND36 FAM83G Protein FAM83G 1 LLPDPGS(1)PR;LLPDPGS(1)PR;LLPDPGS(1)PR;LLPDPGS(1)PR;LLPDPGS(1)PR 123.62 0.0055697 42687600.0 248983.0 209744.0 254532.0 249572.0 263858.0 192801.0 182542.0 167956.0 144639.0 188650.0 True False 235145.52161791973 225830.69036674313 238155.68823348786 215579.8630642869 230709.79911955135 219357.58767677908 191030.56470011093 168444.72415338753 173570.84155132397 183203.1843284356 1.2835231138579177 1.2326788488669909 1.2999538687413683 1.1767255239287127 1.2593110756522046 1.197345933046273 1.0427251327555687 0.919442119801859 0.9474226236163923 1.0 17.483085054153968 -7.32618008902941 2.2237105003927815 0.9497473533537798 1.2481132063342615 0.9268857672032631 0.03710181216987536 0.0734335881462341 0.7096138618975367 0.018133020624232752 0.011212041399192532 4.718673313141483e-08 7.32618008902941 0.2983658529804817 LLPEGEETLES(ph)DDEKDEHTSK ddPTM_A459_Selumetinib_30min_R1 2 LLPEGEETLESDDEKDEHTSK 21 1 Q8N6N3 Q8N6N3 C1orf52 UPF0690 protein C1orf52 1 LLPEGEET(0.133)LES(0.862)DDEKDEHT(0.001)S(0.003)K;LLPEGEET(0.007)LES(0.991)DDEKDEHT(0.002)S(0.001)K 74.0 0.0014532 86588000.0 15155.6 20161.8 17306.8 19693.5 19463.5 18080.5 20387.4 14998.5 7410.299999999999 14492.5 True False 15508.69599233595 17801.24708303346 14956.631619447524 16254.399917779432 17703.029861560022 17898.626585780505 18849.562004010102 14600.691058005883 12574.737873101838 16352.753543904364 0.9483843776338791 1.08857795937792 0.9146246581220411 0.9939855006154854 1.082571801380752 1.0945328893831692 1.1526842836224633 0.8928582589351395 0.768967613884769 1.0 13.997245962652743 -7.903131771602932 8.07952471748142 0.8669803398221884 1.0382076232927937 0.3950697348474551 0.08568329058960328 0.22490725814234463 16.34106237724925 0.04744679335376146 0.02269144827728215 1.2498797400073846e-08 7.903131771602932 0.17122728347060534 LLPEGEETLES(ph)DDEKDEHTSK ddPTM_A459_Selumetinib_30min_R2 3 LLPEGEETLESDDEKDEHTSK 21 1 Q8N6N3 Q8N6N3 C1orf52 UPF0690 protein C1orf52 1 LLPEGEET(0.01)LES(0.96)DDEKDEHT(0.024)S(0.006)K;LLPEGEET(0.002)LES(0.514)DDEKDEHT(0.371)S(0.113)K;LLPEGEET(0.001)LES(0.98)DDEKDEHT(0.009)S(0.009)K 73.953 0.0014688 84551000.0 261007.0 197872.0 341958.0 435141.0 405171.0 298841.0 273439.0 312668.0 288283.0 379112.0 True False 246501.27583380573 213048.14614123924 319956.7945757195 375874.04513990565 354269.7967053023 340003.6351414997 286154.4553090994 313577.8121150261 345947.65530002565 368166.0515087295 0.6695383097481518 0.5786740664115461 0.8690556700286449 1.0209361878956222 0.962255469382685 0.9235062107116574 0.7772429156258435 0.8517292966855499 0.9396511543700083 1.0 18.489997076741076 -5.33315238167616 5.037557418121411 0.9156701663793033 0.6244162945558192 0.7388310822989402 0.07021039739134971 0.10576877573562318 5.024022113876499 0.020068737349293028 0.04397368788190143 4.6435231851329285e-06 5.33315238167616 -0.29125387182348417 LLPETVS(ph)PSAPSWR ddPTM_A459_Selumetinib_30min_R2 2 LLPETVSPSAPSWR 14 0 B0QXZ6;O95503 B0QXZ6 CBX6 Chromobox protein homolog 6 1 LLPET(0.26)VS(0.63)PS(0.11)APSWR;LLPET(0.187)VS(0.466)PS(0.328)APS(0.019)WR 141.65 0.00055259 5060700.0 25807.1 21711.7 26718.2 31848.0 29758.0 22860.7 23638.0 25414.0 20382.6 23957.0 True False 24372.844696006636 23376.917575881133 24999.180100576643 27510.2474591356 26019.534000104628 26009.55391622732 24737.2138378084 25487.950532485796 24459.6895374278 23265.2991622387 1.047605041570476 1.004797635004135 1.0745264836805606 1.1824583585749355 1.118383813535321 1.1179548448894543 1.063266526912266 1.0955350436178626 1.0513378472746089 1.0 14.505892117992268 -5.511187297032037 24.697355738353128 1.0976513180283343 1.0295664997404854 0.21136972046516755 0.04673403397344821 615.5481357893598 1300298.523822526 0.012446315133998524 0.023773653160736683 3.0818585586225907e-06 5.511187297032037 -0.06808481828784885 LLPHAVSSLLCIELFQS(ph)LSCK ddPTM_A459_Selumetinib_30min_R1 1 LLPHAVSSLLCIELFQSLSCK 21 0 Q9UBD5-3;Q9UBD5;Q9UBD5-2 Q9UBD5-3 ORC3 Origin recognition complex subunit 3 1 LLPHAVSSLLCIELFQS(0.5)LS(0.5)CK 54.368 0.023253 167350000.0 1460.6 2081.1 1914.6 2232.1 1971.9 1574.6 1795.1 1526.7 922.98 1279.3 True False 1494.6291381671388 1837.4438445228577 1654.6078361449977 1842.3056367062975 1793.5419931672209 1558.7609536224095 1659.694161756699 1486.206956579497 1566.2296482079705 1443.5106164372503 1.0354126399541521 1.2728994325361318 1.1462387718552147 1.2762674660843984 1.2424861810811536 1.0798403114412904 1.1497623521834668 1.0295781268638164 1.0850142911131508 1.0 10.495366002714022 -7.413163387346938 1.1898320038120005 1.0353630484575091 1.1961176620797054 0.4059160274376158 0.0753471831962321 0.473596450777801 1.2736982492226425 0.05290257867252632 0.02661116352077814 3.8622164800949874e-08 7.413163387346938 0.16075461362219623 LLPLEEHYR ddPTM_A459_Selumetinib_30min_R1 1 LLPLEEHYR 9 0 Q9NZN4;C9JIJ3;C9IZH1;C9JC03;Q9NZN3-2;Q9NZN3;A0A024R571;Q9H4M9 Q9NZN4;A0A024R571 EHD2;EHD1;EHD3 EH domain-containing protein 2;EH domain-containing protein 3;EH domain-containing protein 1 0 182.98 0.0023376 6710200.0 571.9 741.0 1080.6 838.97 725.25 634.7 767.12 722.61 377.31 607.13 False True 585.2241572763153 654.2433755184459 933.860455310918 692.4596389173798 659.6512655532873 628.3154942614909 709.2555207881445 703.4440354319187 640.2675123679275 685.0610494470006 0.854265700478408 0.9550147042319344 1.363178443825926 1.0107998980183612 0.9629087306682743 0.9171671557866029 1.0353172485294184 1.0268340843487704 0.9346138024994536 1.0 9.420088749833102 -5.987880309416821 24.999477685811538 0.9810704147953144 1.0705307257020202 0.0689019204845448 0.12558831593794811 605.3408914255705 1248634.6249075136 0.03701603162701483 0.0548629730101599 1.0282996561524979e-06 5.987880309416821 0.08946031090670581 LLPLEEHYR ddPTM_A459_Selumetinib_30min_R2 1 LLPLEEHYR 9 0 Q9NZN4;C9JIJ3;C9IZH1;C9JC03;Q9NZN3-2;Q9NZN3;A0A024R571;Q9H4M9 Q9NZN4;A0A024R571 EHD2;EHD1;EHD3 EH domain-containing protein 2;EH domain-containing protein 3;EH domain-containing protein 1 0 209.19 0.0049773000000000005 2382200.0 1193.9 2418.4 3560.8 2937.0 3115.6 910.28 3098.2 2796.7 1014.7 2593.0 False True 1127.5478175603735 2603.8835036183705 3331.702004705904 2536.975533392404 2724.190474182605 1035.6628073008878 3242.272438966832 2804.83793398139 1217.6683530868484 2518.133352576905 0.4477712891600873 1.0340530619451562 1.3230840222565823 1.007482598487573 1.0818293127307312 0.41128195464352724 1.2875697927788006 1.113855996193009 0.4835599162533471 1.0 11.298138970422427 LLPPAS(ph)P ddPTM_A459_Selumetinib_30min_R1 2 LLPPASP 7 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 LLPPAS(1)P;LLPPAS(1)P 101.64 0.036573 11665400.0 4567.12 5907.4 5572.6 5240.59 6189.1 5516.5 5539.1 5503.1 2988.5299999999997 4356.360000000001 True False 4673.525009931465 5215.758861724249 4815.871528100706 4325.419334557888 5629.296997774356 5461.009018581245 5121.281227445004 5357.139911411955 5071.317136404871 4915.541240539815 0.9507650899940834 1.0610751912136263 0.9797235527967694 0.8799477255698661 1.1452038996943006 1.1109679995242046 1.0418550016849408 1.0898372425868703 1.031690487017041 1.0 12.263134562276262 -6.270456360808404 24.989366138407945 1.0750662035624565 0.9753809566099592 0.4337901248723599 0.05667592368988047 651.1765463511265 1804646.0691912614 0.017781140925528783 0.02044368166717528 5.364677745977426e-07 6.270456360808404 -0.09968524695249736 LLPPVGTGRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LLPPVGTGRSPR 12 1 Q9NWZ5;Q9NWZ5-3;Q9NWZ5-2;Q9NWZ5-4 Q9NWZ5 UCKL1 Uridine-cytidine kinase-like 1 1 LLPPVGT(0.004)GRS(0.996)PR 98.676 0.0082851 28338000.0 3262.0 3768.6 4847.8 4717.8 3578.5 3923.2 3420.9 3601.4 2595.3 2189.9 True False 3337.99825325291 3327.370560025393 4189.495387059291 3893.9247940741775 3254.8253068354907 3883.7361699805942 3162.8587588176097 3505.879173004129 4404.034546787738 2470.9949964323723 1.3508721215835398 1.3465711443485144 1.6954689884472016 1.5758529659899085 1.3172124231472804 1.5717296779588548 1.2799939956916755 1.4188127365963608 1.7822919727260849 1.0 11.270876373989443 -7.245299302627841 24.68319475149077 1.4051757085357706 1.4776466868925904 0.04706946796854461 0.21146509277101763 3429.2025411395616 5244322.881069593 0.07991913326055415 0.061693596259510944 5.684610296595409e-08 7.245299302627841 0.07247097835681982 LLPPVGTGRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 LLPPVGTGRSPR 12 1 Q9NWZ5;Q9NWZ5-3;Q9NWZ5-2;Q9NWZ5-4 Q9NWZ5 UCKL1 Uridine-cytidine kinase-like 1 1 LLPPVGTGRS(1)PR;LLPPVGT(0.001)GRS(0.999)PR 118.16 0.0025237 15763000.0 58177.0 63764.0 57654.0 64521.0 70782.0 46232.0 39475.7 34430.3 32758.0 57174.0 True False 54943.755240983206 68654.4937664247 53944.60440892891 55733.12849506688 61889.732360891285 52600.03834768936 41311.39826961559 34530.48647275701 39310.51533499454 55523.23806410798 0.9895632379643332 1.2365001783065168 0.9715680549222228 1.0037802267712945 1.1146635988598586 0.947351778852605 0.7440379867960297 0.6219105310984849 0.708001130798712 1.0 15.760804086565193 -7.117041978688463 3.062518284076559 0.7355844808856062 1.0634853103579178 0.5826607433232387 0.11603319187729938 0.16849290946291767 3.008849180758546 0.046736635475610695 0.035251171459949014 7.63761955159194e-08 7.117041978688463 0.3279008294723116 LLPS(ph)PVTCTPK ddPTM_A459_Selumetinib_30min_R1 2 LLPSPVTCTPK 11 0 Q9BU19-5;H0YCH4;Q9BU19-2;Q9BU19 Q9BU19-5 ZNF692 Zinc finger protein 692 1 LLPS(0.995)PVT(0.005)CTPK;LLPS(0.651)PVT(0.348)CT(0.001)PK 153.75 0.00055505 51272000.0 6378.6 7202.5 8012.5 8381.6 7175.799999999999 6421.700000000001 6902.0 6603.9 4123.1 5172.299999999999 True False 6527.208969404972 6359.227951648595 6924.446509512058 6917.910902117966 6526.750156990388 6357.103528437085 6381.37658316792 6428.743119509623 6996.599560690687 5836.215087468455 1.1183976038546322 1.0896150769534103 1.186461843118198 1.185342006495294 1.1183189891346967 1.0892510699420732 1.0934101104104335 1.1015260786590007 1.1988248301050135 1.0 12.510817337881228 -6.512708160562998 23.221706362172647 1.1028634621751314 1.1449492219428339 0.1553219894853941 0.05214178598227983 424.0604117358105 968229.356111839 0.01672140777889541 0.017741041687461163 3.0710850186382576e-07 6.512708160562998 0.04208575976770246 LLPS(ph)PVTCTPK ddPTM_A459_Selumetinib_30min_R2 1 LLPSPVTCTPK 11 0 Q9BU19-5;H0YCH4;Q9BU19-2;Q9BU19 Q9BU19-5 ZNF692 Zinc finger protein 692 1 LLPS(0.628)PVT(0.366)CT(0.005)PK 121.21 0.0045076 21581000.0 70450.0 69131.0 75868.0 76647.0 73651.0 56086.0 64753.0 55185.0 52961.0 67815.0 True False 66534.67103369496 74433.12540879972 70986.73547883274 66207.54637654999 64398.302931705955 63811.3374019836 67764.14280563543 55345.579213631434 63554.67985397909 65857.0047454698 1.0102899652184951 1.1302233634292311 1.077891953227888 1.0053227691182585 0.9778504683077893 0.9689377409222831 1.0289587731409364 0.8403901669615268 0.9650405465540234 1.0 16.007049277496634 -6.0117953665028905 1.865483078238342 0.9565970455935078 1.080073975014804 0.4492284810000279 0.0535928902972143 0.2979858515846642 2.0819185289619964 0.017714267982184468 0.0284211922863135 9.73205676689054e-07 6.0117953665028905 0.12347692942129629 LLPSAPQTLPDGPLAS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 5 LLPSAPQTLPDGPLASPAR 19 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 O15027 SEC16A Protein transport protein Sec16A 1 LLPS(0.002)APQT(0.005)LPDGPLAS(0.994)PAR;LLPSAPQTLPDGPLAS(0.999)PAR;LLPSAPQT(0.002)LPDGPLAS(0.997)PAR;LLPSAPQTLPDGPLAS(1)PAR;LLPSAPQTLPDGPLAS(1)PAR 224.8 6.375900000000001e-20 91809400.0 113188.2 96162.9 112351.9 94188.1 124800.7 97450.8 128273.2 127754.6 117554.3 119771.8 True False 106897.65297226503 103538.28521754176 105123.30107349933 81359.51829646474 109122.12033358612 110873.76312971546 134238.1579685238 128126.34473508758 141068.44474157633 116313.67692949148 0.9190462875407646 0.8901643207471287 0.9037914013949049 0.6994836759032586 0.9381710149162868 0.9532306608871658 1.1541046720575947 1.101558717060908 1.2128276610762723 1.0 16.827661222823338 -7.025400305086317 2.1852808157129955 1.1272351427629046 0.8610707962406168 0.6809736784329188 0.07955214965617442 0.17648873336127063 1.6830892163783606 0.034313831170494045 0.02645398970519217 9.431911018080217e-08 7.025400305086317 -0.2661643465222878 LLPVINTMLQLS(ph)PEEK ddPTM_A459_Selumetinib_30min_R1 2 LLPVINTMLQLSPEEK 16 0 Q99666;O14715;J3KQ37;Q8IWJ2 Q99666;Q8IWJ2 RGPD5;RGPD8;GCC2 RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8;GRIP and coiled-coil domain-containing protein 2 1 LLPVINTMLQLS(1)PEEK;LLPVINTMLQLS(1)PEEK 251.04 1.8095e-29 63494000.0 9593.4 11567.2 12658.0 12395.0 9849.2 10658.7 10013.5 9305.5 5929.1 8793.8 True False 9816.907554493093 10212.906846554615 10939.113125416994 10230.445932966519 8958.341599017493 10551.483155325277 9258.173633084903 9058.68791147607 10061.249655669551 9922.5698888657 0.9893513136661125 1.029260258273888 1.1024475763775647 1.0310278534239694 0.9028247419118522 1.0633820949112478 0.9330419172429989 0.9129376777321561 1.0139761945097978 1.0 13.276498103435683 -6.0282765637401985 24.19851777582861 0.969168265670408 1.043826093566062 0.2829490285392976 0.052267763118496555 572.8787912033271 490257.77121746156 0.015277579159526286 0.019773645949639845 9.369651466792189e-07 6.0282765637401985 0.0746578278956539 LLPYPTLASPAS(ph)D ddPTM_A459_Selumetinib_30min_R1 2 LLPYPTLASPASD 13 0 P0C1Z6-2;P0C1Z6 P0C1Z6-2 TFPT TCF3 fusion partner 1 LLPYPTLASPAS(1)D;LLPYPTLASPAS(1)D 118.9 0.0033321 9104400.0 3299.8 3937.8 3941.8 4030.5 3468.8999999999996 3312.2 3497.6 3429.7 1998.35 3035.8999999999996 True False 3376.678919706917 3476.7605453664446 3406.52521075752 3326.648836855307 3155.1386074840366 3278.88227523698 3233.7732160660844 3338.7332147643283 3391.0539962907087 3425.58733717021 0.9857226184448431 1.0149385209482085 0.9944353698982211 0.9711177994963534 0.9210504059401433 0.9571737493476318 0.9440054792873627 0.9746454800718555 0.9899190014790198 1.0 11.742135652524214 -5.788910300972784 3.828905915616713 0.960703702619 1.0008771458686267 0.31040042173012816 0.02218741649582507 0.2311083142758325 7.242338278920849 0.006454749136151103 0.01061104410929818 1.6258845306842753e-06 5.788910300972784 0.040173443249626795 LLQDSS(ph)SPVDLAK ddPTM_A459_Selumetinib_30min_R1 1 LLQDSSSPVDLAK 13 0 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 LLQDSS(0.5)S(0.5)PVDLAK 150.22 0.00049846 3884600.0 3060.2 3281.7 3763.5 3820.4 3544.6 3353.4 3339.5 3196.0 1740.0 2712.5 True False 3131.4967058873576 2897.4770383790606 3252.4373714257267 3153.2388577898564 3223.9915558499574 3319.667840643585 3087.5988263531262 3111.2316979289135 2952.652915428146 3060.6757969874484 1.0231389776629125 0.9466788482566431 1.0626533442800523 1.0302426872174817 1.0533593786781523 1.0846192347164167 1.0087964329290209 1.0165178883014092 0.9647061993087844 1.0 11.579634519710073 -7.9584690802472595 2.4484303918237273 0.9836546514563589 1.0313843200407091 0.2117943623423295 0.03571707560607497 0.5006663955572648 5.727586076584058 0.028927150318754948 0.01044288810921141 1.1003501823363565e-08 7.9584690802472595 0.04772966858435024 LLQDSS(ph)SPVDLAK ddPTM_A459_Selumetinib_30min_R2 3 LLQDSSSPVDLAK 13 0 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 LLQDS(0.011)S(0.495)S(0.495)PVDLAK;LLQDS(0.001)S(0.5)S(0.5)PVDLAK;LLQDS(0.021)S(0.489)S(0.489)PVDLAK 172.26 0.00018023 13241700.0 127929.0 114984.0 130456.0 141143.0 131719.0 101641.0 103653.0 109051.0 82924.0 107518.0 True False 120819.21832036274 123802.90306816706 122062.60298975333 121919.07991474445 115171.28163719946 115641.12514486702 108473.0698845231 109368.32035563514 99511.11709014847 104413.67597468698 1.1571206280454387 1.185696240578491 1.1690288829534647 1.1676543209177053 1.103028703492064 1.1075285307731328 1.0388779905691687 1.0474520634839952 0.9530467743925898 1.0 16.671951161140406 -7.152856797709789 0.7587486854691937 0.98135094119152 1.1772824177740462 0.9152508412736873 0.02209596691897868 0.1675918669310934 0.1944759433743608 0.016856190915499763 0.011445490163137199 7.033041859828823e-08 7.152856797709789 0.1959314765825262 LLQDSSS(ph)PVDLAK ddPTM_A459_Selumetinib_30min_R1 1 LLQDSSSPVDLAK 13 0 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 LLQDS(0.023)S(0.087)S(0.89)PVDLAK 196.18 0.00019383 8026400.0 3699.2 4752.2 5334.9 5269.8 4255.7 3873.2 4609.1 4145.4 2220.6 3517.9 True False 3785.384162609802 4195.8102147621585 4610.44988250807 4349.528356397493 3870.772686404858 3834.2391245842223 4261.4318761923 4035.450525843091 3768.1960137929555 3969.4567322477974 0.9536277677137546 1.0570237938797693 1.161481329435551 1.0957490280878992 0.9751391556831362 0.965935487704131 1.073555441875081 1.016625396885967 0.9492976666505007 1.0 11.954725855424861 -6.260483218362236 24.993977620970576 0.9998887880704556 1.0730107782412273 0.26120969366334623 0.057344302362657626 129.80041062982755 3392954.00332568 0.018486629587352543 0.022462390612422105 5.489297664741066e-07 6.260483218362236 0.0731219901707717 LLQNGNS(ph)PAEVAK ddPTM_A459_Selumetinib_30min_R2 2 LLQNGNSPAEVAK 13 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 LLQNGNS(1)PAEVAK;LLQNGNS(1)PAEVAK 177.04 0.00010289 11481500.0 60206.0 55661.0 53988.0 68248.0 66875.0 44519.0 51054.0 59507.0 47296.0 55261.0 True False 56859.99154371373 59930.019721676304 50514.470857689914 58952.50466563327 58473.564629914545 50651.08814675509 53428.112161581754 59680.155518085856 56756.52156065395 53665.47134467889 1.0595265469396011 1.1167333151098573 0.941284397434042 1.0985183431446486 1.0895937958758355 0.9438301179064799 0.995577059566427 1.1120773566820326 1.0575984918891717 1.0 15.711706528434881 LLQPGGGPDVGTGAPRPGCS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 LLQPGGGPDVGTGAPRPGCSPR 22 1 Q9NXH8 Q9NXH8 TOR4A Torsin-4A 1 LLQPGGGPDVGT(0.004)GAPRPGCS(0.996)PR;LLQPGGGPDVGT(0.002)GAPRPGCS(0.998)PR;LLQPGGGPDVGT(0.002)GAPRPGCS(0.998)PR 149.82 8.576499999999999e-08 14952000.0 4802.02 2972.63 5435.099999999999 5308.08 5270.25 3779.29 4527.639999999999 4980.48 3075.8900000000003 3982.95 True False 4913.897722895629 2624.5930976618047 4697.0432728672695 4381.123473002089 4793.556818038209 3741.2737739207682 4186.1164695761245 4848.3814915209605 5219.560675882918 4494.2004297183985 1.093386420953088 0.583995560212756 1.0451343562266493 0.9748393605303902 1.0666094877167211 0.832467050018771 0.931448549088947 1.078808470459061 1.1613991760064803 1.0 12.13384875108307 -7.770840639686249 5.70421471871179 1.092266902970945 0.9259567539064739 0.18155402644594731 0.142623165845582 0.2588694589676272 27.7839093433291 0.07422569748487726 0.037542968994099125 1.6949596359982216e-08 7.770840639686249 -0.16631014906447117 LLQPGGGPDVGTGAPRPGCS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 LLQPGGGPDVGTGAPRPGCSPR 22 1 Q9NXH8 Q9NXH8 TOR4A Torsin-4A 1 LLQPGGGPDVGTGAPRPGCS(1)PR;LLQPGGGPDVGT(0.099)GAPRPGCS(0.901)PR 95.209 0.00012055 69685000.0 179511.0 77820.0 152051.0 178721.0 180864.0 121517.0 150177.0 163530.0 130121.0 118389.0 True False 169534.49725946935 83788.54376926122 142268.2042006116 154378.89148907881 158142.24737532507 138254.86372850326 157160.52807008024 164005.84522615108 156148.83588451112 114970.801958437 1.4745874115130346 0.7287810673839741 1.2374289974253014 1.342766066334722 1.3754992109430961 1.2025215217554424 1.366960353350368 1.4264999672302947 1.3581607958250161 1.0 16.81090799457852 -5.509415282415142 24.76107691807647 1.31418848278749 1.0720394373075697 0.11739241631595487 0.20321493075196687 822.4375919717611 1512567.628471636 0.04989688033385498 0.09706564042324588 3.0944588909679155e-06 5.509415282415142 -0.24214904547992022 LLQTCFS(ph)SPADDSMDR ddPTM_A459_Selumetinib_30min_R1 2 LLQTCFSSPADDSMDR 16 0 Q9NZL4-2;Q9NZL4;Q9NZL4-3 Q9NZL4-2 HSPBP1 Hsp70-binding protein 1 1 LLQTCFS(0.883)S(0.117)PADDSMDR;LLQT(0.003)CFS(0.722)S(0.275)PADDSMDR 263.99 1.7862000000000005e-39 48929000.0 3803.3999999999996 4111.299999999999 4640.200000000001 4407.0 4115.0 4132.0 3394.9 3322.5 2113.07 3017.6000000000004 True False 3892.0118198718983 3629.9470847084854 4010.086326794118 3637.4001796356156 3742.7989765622565 4090.4358315558247 3138.8199597503285 3234.3765069990054 3585.7254574734225 3404.938353913115 1.1430491290390077 1.0660830556702385 1.177726557717422 1.0682719631194921 1.0992266489232783 1.201324490017537 0.921843403168533 0.9499075080997893 1.0530955585003583 1.0 11.733412963278603 -7.267353049367918 24.99168488546929 0.9770372415761481 1.1217433531671837 0.654218706930022 0.05145874299549822 301.4921863274781 1274126.7704917046 0.02074569651007235 0.01442564059105279 5.403149082124669e-08 7.267353049367918 0.14470611159103552 LLQTCFS(ph)SPADDSMDR ddPTM_A459_Selumetinib_30min_R2 3 LLQTCFSSPADDSMDR 16 0 Q9NZL4-2;Q9NZL4;Q9NZL4-3 Q9NZL4-2 HSPBP1 Hsp70-binding protein 1 1 LLQT(0.001)CFS(0.974)S(0.025)PADDSMDR;LLQTCFS(0.735)S(0.265)PADDSMDR;LLQTCFS(0.872)S(0.128)PADDSMDR 277.0 2.1602999999999998e-62 9323300.0 41834.3 45736.0 50745.0 50262.0 54217.0 41278.8 35754.1 31625.2 33588.4 48653.0 True False 39509.31708197163 49243.804135581275 47480.1219469785 43416.228893213854 47405.77575387031 46964.58000836212 37416.73649540509 31717.224096166316 40307.01853830912 47248.261474324805 0.8362067904538965 1.0422352611289385 1.0049072805097747 0.9188957971883618 1.0033337582088835 0.9939959385359218 0.7919177410524986 0.6712887015621047 0.8530899821618277 1.0 15.527973625105083 -7.264118318065944 24.81410897280829 0.8016814883100842 0.97127711971746 0.3249875415583734 0.09368473379860609 203.1218366290058 1881433.223153666 0.03641618317560247 0.025812772758053465 5.4435433015253085e-08 7.264118318065944 0.16959563140737577 LLQTCFSSPADDS(ph)MDR ddPTM_A459_Selumetinib_30min_R1 1 LLQTCFSSPADDSMDR 16 0 Q9NZL4-2;Q9NZL4;Q9NZL4-3 Q9NZL4-2 HSPBP1 Hsp70-binding protein 1 1 LLQT(0.001)CFS(0.295)S(0.171)PADDS(0.533)MDR 82.663 0.019694 2358900.0 485.18 485.6 912.2 638.36 545.31 362.9 409.74 543.05 190.29 356.12 True False 496.48375000406145 428.74572625068464 788.3282503559313 526.8824095012912 495.9868067823001 359.24955548683636 378.83298191643337 528.6465499249988 322.9082317682882 401.831470902551 1.2355521803429497 1.066978963314351 1.9618380028455025 1.3112024509127276 1.2343154847186741 0.8940304120031423 0.9427658343074501 1.3155927004363528 0.8035911946941492 1.0 8.650446748213895 -6.478862504291986 2.958355531147097 1.009524456903916 1.4093604966140927 0.36590151016485783 0.24899031994334048 0.31117659652891594 5.438391200373266 0.08651530716467513 0.094820369233105 3.3199955050189335e-07 6.478862504291986 0.3998360397101768 LLQTCFSSPADDS(ph)MDR ddPTM_A459_Selumetinib_30min_R2 2 LLQTCFSSPADDSMDR 16 0 Q9NZL4-2;Q9NZL4;Q9NZL4-3 Q9NZL4-2 HSPBP1 Hsp70-binding protein 1 1 LLQTCFS(0.02)S(0.02)PADDS(0.959)MDR;LLQT(0.001)CFS(0.243)S(0.243)PADDS(0.513)MDR 115.31 0.0020101 2567600.0 10262.3 12271.8 12750.8 12954.1 14464.5 9533.0 7991.0 10035.5 10396.6 11253.0 True False 9691.962449241837 13213.007599943714 11930.427410021353 11189.729232931068 12647.340195729319 10846.084218042095 8362.597333866106 10064.70164353354 12476.210505275176 10928.096651194724 0.8868847667248856 1.2090859023011284 1.0917205247006163 1.0239412763344968 1.157323237468497 0.9924952683188739 0.7652382295641443 0.9209931028962127 1.1416636312336423 1.0 13.415754527951758 -6.9905537968398255 23.15224023772793 0.9401722631495081 1.0790717432565726 0.1774275135975032 0.1176052965244483 123.0418777142727 301566.11574177933 0.04125808223995502 0.03632265651399658 1.0219889571457696e-07 6.9905537968398255 0.13889948010706454 LLS(ph)DPELSATESPLADK ddPTM_A459_Selumetinib_30min_R1 7 LLSDPELSATESPLADK 17 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 LLS(0.998)DPELS(0.002)ATESPLADK;LLS(0.999)DPELSAT(0.001)ESPLADK;LLS(1)DPELSATESPLADK;LLS(1)DPELSATESPLADK;LLS(1)DPELSATESPLADK;LLS(1)DPELSATESPLADK;LLS(0.92)DPELS(0.079)AT(0.001)ESPLADK 313.92 3.4237999999999986e-111 121181000.0 11764.56 14078.34 13382.39 14458.119999999999 12213.65 11720.66 13631.400000000001 12461.189999999999 6827.05 11446.32 True False 12038.651358151152 12430.041407957298 11565.134942206434 11933.280754525354 11108.927513995046 11602.760801907812 12603.172523296898 12130.678761550316 11585.005221996396 12915.566668598472 0.9321040003161952 0.9624077461640435 0.8954415426715009 0.9239455813842575 0.8601192498199947 0.8983547605477911 0.9758125869876778 0.9392293093142828 0.8969800179316126 1.0 13.6568233224279 -7.246573372296717 24.723497694067714 0.9479412564836136 0.91177421623663 0.24020198745343613 0.035213833857610476 1231.2884669601526 2047744.050066661 0.014008489479886177 0.010804865113896472 5.667958055741797e-08 7.246573372296717 -0.036167040246983584 LLS(ph)DPELSATESPLADK ddPTM_A459_Selumetinib_30min_R2 6 LLSDPELSATESPLADK 17 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 LLS(0.997)DPELS(0.002)ATESPLADK;LLS(1)DPELSATESPLADK;LLS(1)DPELSATESPLADK;LLS(0.988)DPELS(0.003)AT(0.008)ES(0.001)PLADK;LLS(1)DPELSATESPLADK;LLS(1)DPELSATESPLADK 212.95 3.8060000000000004e-14 28448000.0 169334.90000000002 161885.60000000003 169744.3 168397.5 174349.60000000003 130775.6 150772.9 153208.9 110106.7 165525.9 True False 159923.94415931316 174301.70497575303 158823.1365416201 145461.4699981094 152446.24454279986 148788.75183730075 157784.13860083357 153654.71253390127 132131.1166382456 160746.73717906285 0.9948814325305207 1.0843249949241005 0.9880333456765598 0.9049108712923577 0.9483629168347181 0.9256097787637109 0.9815697747262571 0.955880755220173 0.8219831951615849 1.0 17.294429928609887 -5.528861784084582 5.4374088084644825 0.9348647136613321 1.0395673518470263 0.42235580111794757 0.049803645894029115 0.1437937332524724 14.009987077286974 0.013018825308296997 0.024565781868949605 2.9589540153922217e-06 5.528861784084582 0.10470263818569425 LLS(ph)DPELSATESPLADKK ddPTM_A459_Selumetinib_30min_R1 2 LLSDPELSATESPLADKK 18 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 LLS(1)DPELSATESPLADKK;LLS(1)DPELSATESPLADKK 200.73 7.884899999999998e-11 102330000.0 4652.2 5412.200000000001 5543.0 5832.9 5092.5 4354.8 5098.1 5071.6 2784.3 4193.8 True False 4760.587208394606 4778.537107936482 4790.291045519547 4814.293512093621 4631.884274153899 4310.994665842036 4713.546212496145 4937.084693121492 4724.7537427739035 4732.11508107132 1.0060167867508498 1.0098099953339792 1.012293860874376 1.0173661099982583 0.9788190259111939 0.9110079936741637 0.9960759896458454 1.0433145873544074 0.9984443873043447 1.0 12.20826944390024 -7.541056887264679 24.63513277218418 1.0164667651235233 0.9888047609056219 0.11150204749573456 0.03094152565066603 464.3662615937373 629302.9271568824 0.01603194247681647 0.009257887321000831 2.8770215354245677e-08 7.541056887264679 -0.027662004217901437 LLS(ph)DPELSATESPLADKK ddPTM_A459_Selumetinib_30min_R2 4 LLSDPELSATESPLADKK 18 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 LLS(0.995)DPELS(0.005)ATESPLADKK;LLS(0.996)DPELS(0.004)ATESPLADKK;LLS(0.999)DPELS(0.001)ATESPLADKK;LLS(0.994)DPELS(0.006)ATESPLADKK 123.43 0.00045577 13675900.0 96754.0 89919.0 97525.0 103157.0 86421.0 68229.0 80273.0 79682.0 62660.0 93023.0 True False 91376.80001694993 96815.49816484474 91250.34767719152 89106.8386442491 75564.02136645738 77626.92542880456 84005.85355793193 79913.86142793487 75193.75086668156 90337.18428721989 1.0115081706158193 1.0717125946390753 1.0101083888896547 0.9863805181368173 0.8364664225775246 0.8593020254206278 0.9299144557222638 0.8846175808829186 0.8323676618878114 1.0 16.46303232677439 -6.0552227569930155 3.6171329997936343 0.8853857443998292 1.0326318028217831 0.6338026983455805 0.04881174003428347 0.141271389443636 3.7054065689647455 0.014304921897818032 0.019873133570588425 8.8059708399861e-07 6.0552227569930155 0.14724605842195393 LLS(ph)DSLPPSTGTFQEAQSR ddPTM_A459_Selumetinib_30min_R1 4 LLSDSLPPSTGTFQEAQSR 19 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 LLS(0.991)DS(0.009)LPPSTGTFQEAQSR;LLS(0.667)DS(0.302)LPPS(0.011)T(0.015)GT(0.004)FQEAQS(0.001)R;LLS(0.999)DS(0.001)LPPSTGTFQEAQSR;LLS(0.993)DS(0.007)LPPSTGTFQEAQSR 254.02 4.2472000000000005e-38 50470300.0 5824.53 6162.4 6473.76 6495.610000000001 7065.33 6312.92 5817.7300000000005 5612.22 3270.6499999999996 4472.360000000001 True False 5960.230216437515 5440.903343177964 5594.658949818261 5361.27365120102 6426.272148985324 6249.41775647275 5378.893942218709 5463.365694540239 5550.054171175324 5046.430970475495 1.1810783207594175 1.078168585879874 1.1086367737020904 1.0623891781275785 1.2734291198240277 1.2383836800771506 1.065880812338128 1.0826197220380207 1.0997978974935578 1.0 12.30104770390091 -8.376476377999456 0.9932005560089974 1.0081681270858454 1.145930543724164 0.29644293762848584 0.06794080781801615 0.7482239622874919 1.5972522811623393 0.0700999136406578 0.02388315046543629 4.202653859902959e-09 8.376476377999456 0.13776241663831867 LLS(ph)DSLPPSTGTFQEAQSR ddPTM_A459_Selumetinib_30min_R2 9 LLSDSLPPSTGTFQEAQSR 19 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 LLS(0.999)DS(0.001)LPPSTGTFQEAQSR;LLS(0.942)DS(0.058)LPPSTGTFQEAQSR;LLS(0.979)DS(0.021)LPPSTGTFQEAQSR;LLS(0.991)DS(0.009)LPPSTGTFQEAQSR;LLS(0.999)DS(0.001)LPPSTGTFQEAQSR;LLS(0.993)DS(0.007)LPPSTGTFQEAQSR;LLS(0.713)DS(0.287)LPPSTGTFQEAQSR;LLS(1)DSLPPSTGTFQEAQSR;LLS(0.999)DS(0.001)LPPSTGTFQEAQSR 195.17 3.3630000000000004e-15 32425500.0 157177.80000000002 146963.9 166843.9 167911.19999999998 185566.40000000002 131477.3 138974.30000000002 135317.19999999998 116943.6 156253.00000000003 True False 148442.48710858604 158235.55856658076 156109.34511990327 145041.40489702387 162253.88984733564 149587.10464290212 145436.88032235103 135710.95064903173 140335.58767719215 151741.56989595047 0.9782585431953379 1.0427963719835194 1.0287843023302565 0.9558448946882458 1.069277785636418 0.9858017466504027 0.9584511378264864 0.8943557836002951 0.9248328442457829 1.0 17.21125684325954 -7.253077153584356 2.8480593475323936 0.9325289673474465 1.0144794352536284 0.4084573084875115 0.03922441788292586 0.23623259865911345 3.8488999174383833 0.01697857715319442 0.011587657535812227 5.5837098981493026e-08 7.253077153584356 0.08195046790618188 LLS(ph)FSPEEFPTLK ddPTM_A459_Selumetinib_30min_R1 1 LLSFSPEEFPTLK 13 0 Q5JSZ5;A0A1W2PQP5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 LLS(0.763)FS(0.237)PEEFPTLK 217.91 1.7401e-08 23655000.0 2078.6 2443.1 2422.6 2602.5 2315.4 2240.2 2247.2 2289.2 1156.9 1890.9 True False 2127.0273357484675 2157.060716233624 2093.624226389257 2148.022229975423 2105.9724788170706 2217.665621938856 2077.6918947689 2228.4829796304334 1963.1748033671383 2133.6154339257396 0.9969122372886334 1.010988523018296 0.9812565999942637 1.0067522927612012 0.9870440780146554 1.0393933164696267 0.9737893069821195 1.0444632824623614 0.9201165177901813 1.0 11.059084450718865 -8.261824489543063 24.999993028981006 0.9600582644094403 1.0040341002769282 0.2903358754812555 0.028114367786367663 41.76191678012946 2710447.526146446 0.020331587281751794 0.0063937534992422424 5.47237071905865e-09 8.261824489543063 0.04397583586748788 LLS(ph)GDSTEK ddPTM_A459_Selumetinib_30min_R2 1 LLSGDSTEK 9 0 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 LLS(1)GDSTEK 83.081 0.039708 2340900.0 31428.0 27950.0 29314.0 26403.0 25149.0 28032.0 31477.0 30284.0 29564.0 38932.0 True False 29681.357576252147 30093.675126585083 27427.96915466998 22806.86585228453 21989.5577850874 31893.153550839845 32940.742870492235 30372.121426213907 35477.626087178076 37807.93200251605 0.7850563626245654 0.7959619458843293 0.7254554190598073 0.6032296569610518 0.5816122866393231 0.8435572077498821 0.8712653965919133 0.8033267046764869 0.9383646290100476 1.0 15.206401319292269 -6.926131076968939 7.573302709631572 0.8827644215958712 0.7001890313539082 0.5964317925045899 0.07986938621388434 0.19745192886179497 17.302982319139396 0.03066215786801249 0.02702093954021551 1.1854109183373027e-07 6.926131076968939 -0.182575390241963 LLS(ph)PLRDTPPPQSLMVK ddPTM_A459_Selumetinib_30min_R1 2 LLSPLRDTPPPQSLMVK 17 1 A0A669KBI3;F5GXF9;P51825;P51825-3;P51825-2 A0A669KBI3 AFF1 AF4/FMR2 family member 1 1 LLS(0.99)PLRDT(0.01)PPPQSLMVK;LLS(1)PLRDTPPPQSLMVK 127.37 0.00060371 29096000.0 4180.2 4931.9 7535.0 8453.0 5805.4 5367.700000000001 5084.3 4571.4 2844.74 3670.3 True False 4277.590526746728 4354.470855221891 6511.788386792314 6976.8422324619605 5280.302595026618 5313.705811481656 4700.787157606586 4450.151622000073 4827.316008410957 4141.418756749504 1.0328804639171776 1.0514442298608815 1.5723569069608536 1.6846502713813731 1.2749984739942106 1.2830641197105728 1.1350668535862132 1.074547608774749 1.1656189079029036 1.0 12.01590937187635 -7.22206132948869 2.1523058060191396 1.0888155985583678 1.3401788667909864 0.24794501483952847 0.19189723721484359 0.5331791766159568 4.833210082257461 0.10452154669401495 0.06967644967449267 5.997063819193646e-08 7.22206132948869 0.25136326823261856 LLS(ph)PLSSAR ddPTM_A459_Selumetinib_30min_R1 2 LLSPLSSAR 9 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 LLS(0.996)PLS(0.004)SAR;LLS(0.997)PLS(0.003)SAR 156.16 0.00083589 107114000.0 10990.4 11587.2 12020.2 14289.9 13004.0 10112.7 11491.2 11135.3 7205.900000000001 9112.8 True False 11246.45493640429 10230.56523725686 10387.922862232377 11794.437219644875 11827.790496042664 10010.975419596947 10624.4095323818 10839.95567144801 12227.886001887171 10282.51664618884 1.09374536637125 0.994947597877098 1.0102510134114497 1.1470379893833111 1.1502816774360944 0.9735919487480199 1.0332499229475773 1.0542123144012396 1.1891919481034219 1.0 13.327905786943752 LLS(ph)PLSSAR ddPTM_A459_Selumetinib_30min_R2 4 LLSPLSSAR 9 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 LLS(0.981)PLS(0.01)S(0.01)AR;LLS(0.863)PLS(0.124)S(0.012)AR;LLS(0.984)PLS(0.014)S(0.002)AR;LLS(1)PLSSAR 133.75 0.0030474 276803800.0 141500.0 125749.0 137712.0 162652.0 173728.0 115612.0 118253.0 127199.0 111429.0 124394.0 True False 133635.99646938007 135393.5439532361 128851.75984948847 140498.51700964977 151902.73549197454 131536.50357875618 123751.99881387413 127569.1280310719 133717.9135863947 120802.42200557317 1.1062360692007882 1.12078501163652 1.0666322554654073 1.163043875090252 1.2574477644576245 1.0888565096210387 1.0244165370141742 1.056014655278903 1.1069141774345026 1.0 16.882289854434248 -6.993541634152462 24.992542185254912 1.052237401667155 1.14196001778792 0.42508279994799714 0.052618785552782425 181.11539430000605 700874.9168126631 0.01977803249445176 0.017398786092263557 1.0149820594569265e-07 6.993541634152462 0.08972261612076493 LLS(ph)PQQPALQR ddPTM_A459_Selumetinib_30min_R1 2 LLSPQQPALQR 11 0 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 LLS(1)PQQPALQR;LLS(1)PQQPALQR 122.52 0.0041278 59677000.0 6120.1 6654.4 7164.5 7621.599999999999 7393.099999999999 5602.2 6557.5 5437.200000000001 3715.3999999999996 5170.2 True False 6262.686422358414 5875.299754453368 6191.600251781485 6290.630635151076 6724.395410357817 5545.8469543906185 6062.86249552646 5292.987793485326 6304.762437920534 5833.845532012722 1.0735091266973842 1.0071058142031992 1.061323995948404 1.078299142586444 1.1526522897218103 0.9506331499451371 1.039256603942807 0.9072896710138302 1.0807215246484836 1.0 12.510231471866724 -6.781476098304042 24.999999694068094 0.9925155773670253 1.0703000407945502 0.3403579961450346 0.05474386300582463 288.10838015362026 359473.1436431493 0.018775162623742417 0.016579415173531852 1.6539558088637214e-07 6.781476098304042 0.07778446342752487 LLS(ph)PQQPALQR ddPTM_A459_Selumetinib_30min_R2 4 LLSPQQPALQR 11 0 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 LLS(1)PQQPALQR;LLS(1)PQQPALQR;LLS(1)PQQPALQR;LLS(1)PQQPALQR 150.14 0.00061878 94641900.0 276996.0 285852.0 273540.0 297909.0 332750.0 200191.0 235716.0 229131.0 199397.0 266101.0 True False 261601.67122284352 307775.9292409515 255940.7342078334 257333.28027831 290946.97017725674 227765.49309703853 246677.26106239294 229797.7332753207 239281.97161767795 258417.97271657095 1.0123199577521815 1.1910004788193105 0.9904138304209416 0.9958025657934767 1.1258774578204864 0.8813841030586846 0.9545669694303536 0.8892482626483549 0.9259494186966589 1.0 17.979346885983254 -6.7665305625305985 24.999999667545012 0.9248288351615199 1.0624144330734044 0.5092310712774455 0.0651017515770639 103.05730612024446 506054.4109831369 0.022220016409048773 0.020192955181236687 1.7118647037046385e-07 6.7665305625305985 0.13758559791188452 LLS(ph)PRPSLLTPTGDPR ddPTM_A459_Selumetinib_30min_R1 1 LLSPRPSLLTPTGDPR 16 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 LLS(0.811)PRPS(0.091)LLT(0.091)PT(0.008)GDPR 61.477 0.037923 196890000.0 3220.6 3951.8 4525.6 4949.3 4149.2 3680.7 3804.6 3313.0 2339.9 2512.2 True False 3295.6337138032904 3489.1214188580243 3911.0483773413757 4084.9976648673814 3773.9055926007554 3643.6754998082074 3517.615958898966 3225.1284778593526 3970.6394004656995 2834.6653409002265 1.1626182696955227 1.2308759586237283 1.379721380478485 1.44108639772273 1.3313407893865339 1.285398825475129 1.2409281293790573 1.137745761845426 1.4007436233035935 1.0 11.468962706064964 -7.2928553422688305 2.574220947316332 1.2004134736778234 1.3149926170770414 0.18285152542348426 0.11643206516792173 0.5686874968149339 7.438662269753211 0.055890325871593205 0.03642475525144816 5.0950055067170835e-08 7.2928553422688305 0.11457914339921804 LLS(ph)PRPSLLTPTGDPR ddPTM_A459_Selumetinib_30min_R2 2 LLSPRPSLLTPTGDPR 16 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 LLS(0.666)PRPS(0.257)LLT(0.036)PT(0.041)GDPR;LLS(0.505)PRPS(0.077)LLT(0.412)PT(0.006)GDPR 69.422 0.024884 17650100.0 38123.0 43963.0 40692.0 46681.0 51729.0 33992.0 33912.0 34575.0 30388.0 40426.0 True False 36004.276278460595 47334.820736674825 38073.92102209973 40322.96727078341 45230.34055687247 38674.08945134662 35488.9751953532 34675.6075258006 36466.44911166173 39258.79634063789 0.9171008699823929 1.2057124809931377 0.9698188577087967 1.0271065602957359 1.152107165090369 0.9851063470153815 0.9039751215861287 0.8832570215584246 0.928873335678768 1.0 15.260728320565129 -6.99726250400352 24.65761112156252 0.9229039109348111 1.0577694751208042 0.34176735900950383 0.08195091856733844 73.68294243712417 663679.2761243706 0.02764319579448161 0.02423378256026689 1.0063232251854412e-07 6.99726250400352 0.13486556418599316 LLS(ph)PSNEK ddPTM_A459_Selumetinib_30min_R1 2 LLSPSNEK 8 0 Q14694;Q14694-3;Q14694-2;H3BNA1;J3KT19 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 LLS(0.709)PS(0.291)NEK;LLS(0.907)PS(0.093)NEK 112.85 0.010999 24061300.0 9615.099999999999 10981.1 11223.7 12277.900000000001 10629.2 9797.2 10039.3 9672.4 5386.299999999999 8510.0 True False 9839.113122272245 9695.427707025108 9699.583187371045 10133.795249727278 9667.790736737677 9698.649063145871 9282.027518313194 9415.856531616902 9140.157700213005 9602.341394419607 1.024657707753469 1.0096941265449693 1.0101268835336297 1.055346277900151 1.0068159774402632 1.0100296026531854 0.9666421070706189 0.9805792300916233 0.9518676044495564 1.0 13.229170514064194 -7.090422852866982 2.414361935982425 0.9727649871107161 1.0220524281886298 0.6184192323713698 0.017248282619681164 0.19379190486547745 2.2198955297792153 0.007370249578389957 0.005505508644061254 8.120394850632654e-08 7.090422852866982 0.04928744107791372 LLS(ph)PSNEK ddPTM_A459_Selumetinib_30min_R2 2 LLSPSNEK 8 0 Q14694;Q14694-3;Q14694-2;H3BNA1;J3KT19 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 LLS(0.988)PS(0.012)NEK;LLS(0.615)PS(0.385)NEK 117.02 0.0090641 28045000.0 255030.0 243650.0 270900.0 302270.0 298230.0 235150.0 234546.0 251280.0 186109.0 252020.0 True False 240856.45356597885 262337.1715417701 253470.58893361923 261100.30455516605 260763.68118997273 267539.7780208327 245452.85374408218 252011.1831983566 223336.00031993684 244743.52777340214 0.9841177650629349 1.0718860430281008 1.0356579854822439 1.0668323159781694 1.0654569032420051 1.0931434242810156 1.0028982419969723 1.0296949851588446 0.9125307719136677 1.0 17.90091118279416 -7.903915112003418 2.0206895518177603 0.9606822081058729 1.0520748621857166 0.447765381603908 0.03773392548274797 0.28441251083691105 2.191500825574036 0.028180945845363427 0.010225030724200586 1.2476273539441166e-08 7.903915112003418 0.09139265407984365 LLS(ph)QESR ddPTM_A459_Selumetinib_30min_R2 1 LLSQESR 7 0 D6RBD3;Q3KP44-2;Q3KP44 D6RBD3 ANKRD55 Ankyrin repeat domain-containing protein 55 1 LLS(1)QESR 68.78699999999999 0.047299 727510.0 3370.2 2734.3 2761.5 4496.3 3749.1 2819.7 2745.8 2981.7 2574.4 3094.7 True False 3182.8977759795375 2944.012017839772 2583.828096493863 3883.89618344987 3278.10454062075 3208.0880803118976 2873.4851406994817 2990.376253352993 3089.351934746016 3005.3479700037606 1.0590779529518357 0.9795910647365363 0.8597434048512625 1.292328283518201 1.0907570681795786 1.067459779144271 0.9561239395170225 0.9950183084287745 1.027951493664193 1.0 11.55331632569344 -10.18467641786727 11.426445000141001 0.9999999999983991 1.0360345803926667 0.010494602873708181 0.1061119142614499 0.0 0.0 0.10653707794130562 0.025839036788039088 6.536173654857067e-11 10.18467641786727 0.03603458039426766 LLS(ph)WSDNWR ddPTM_A459_Selumetinib_30min_R1 2 LLSWSDNWR 9 0 J3KSY6;J3KSX6;Q8TCD5 J3KSY6 NT5C 5(3)-deoxyribonucleotidase, cytosolic type 1 LLS(0.987)WS(0.013)DNWR;LLS(0.871)WS(0.129)DNWR 136.81 0.002608 78642000.0 10101.2 11705.2 12279.4 11115.2 8103.5 10247.0 8691.9 9115.6 7563.700000000001 7831.5 True False 10336.538306486307 10334.749742400149 10611.924925916053 9174.13897814518 7370.539855789128 10143.92448353159 8036.262985111166 8873.8246763582 12835.046469209123 8836.749310269937 1.1697217996750613 1.1695193989931634 1.2008855918978072 1.0381802918730685 0.8340781883699243 1.1479248904053976 0.9094139375178995 1.0041955887608098 1.4524624404918247 1.0 13.109300041559953 -5.765644333554972 24.802586438457954 1.0439324264456338 1.1789899877517644 0.11544931530510771 0.15621856750092847 196.72682129623885 1160388.563404122 0.04370922854681095 0.06750918090933983 1.7153615316271252e-06 5.765644333554972 0.13505756130613067 LLSFS(ph)PEEFPTLK ddPTM_A459_Selumetinib_30min_R1 1 LLSFSPEEFPTLK 13 0 Q5JSZ5;A0A1W2PQP5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 LLS(0.001)FS(0.999)PEEFPTLK 203.74 5.1593e-05 26990000.0 4788.2 5053.0 5572.1 5349.2 4450.0 4232.4 4594.8 4478.1 2812.4 4312.8 True False 4899.755743784673 4461.392410924029 4815.439425354403 4415.062636920086 4047.4982857113096 4189.825898711728 4248.2105367053 4359.326241081186 4772.437390431105 4866.389890229482 1.0068563872414293 0.9167766067986889 0.9895301309544936 0.9072562487819666 0.8317250316991028 0.8609720949658948 0.8729696207109638 0.895802913332868 0.9806935938308168 1.0 12.248636196834605 -5.858744593280609 6.23681875154669 0.8954817900811073 0.9652804163285905 0.21089123851476488 0.05353354849460083 0.2891952922463133 15.556005949987822 0.015085065907583187 0.022654366733222596 1.3843802877211105e-06 5.858744593280609 0.06979862624748323 LLSGPSQES(ph)PQTLGK ddPTM_A459_Selumetinib_30min_R2 1 LLSGPSQESPQTLGK 15 0 E7EVL6;C9JZE3;C9JYJ8;Q9BWE0;Q9BWE0-4 E7EVL6 REPIN1 Replication initiator 1 1 LLSGPS(0.001)QES(0.998)PQT(0.001)LGK 136.26 0.00059905 0.0 12318.0 10540.0 10312.0 11957.0 11557.0 10120.0 9853.8 8787.0 7655.5 10654.0 True False 11633.414872860949 11348.384108558392 9648.537146856686 10328.43597302451 10105.106339109114 11513.93813978664 10312.021224934277 8812.568715233838 9186.813912542 10346.391337583631 1.1243934714321273 1.096844661900134 0.9325509573379498 0.9982645770903815 0.9766793086978992 1.1128457994781094 0.9966780579307393 0.8517528892631261 0.887924457213461 1.0 13.336840045130282 -7.59711016030804 5.993025452375767 0.9039322081707212 1.034856326850797 0.41165397148777727 0.06738739907780363 0.2048695151244272 12.547202279063638 0.033510793522727136 0.019100650515519447 2.528656512560214e-08 7.59711016030804 0.13092411868007592 LLSMPGAQGAAAAGSEPPPATTS(ph)PEGQPK ddPTM_A459_Selumetinib_30min_R2 1 LLSMPGAQGAAAAGSEPPPATTSPEGQPK 29 0 A0A0G2JIS2;A2ABF8;A0A0G2JIR1;Q96KQ7-2;A2ABF9;A0A0G2JK64;Q96KQ7-3;Q96KQ7 A0A0G2JIS2 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 LLSMPGAQGAAAAGSEPPPAT(0.219)T(0.293)S(0.488)PEGQPK 82.80799999999998 9.3256e-06 3372300.0 33277.0 35985.0 41259.0 38719.0 37848.0 29071.0 30759.0 34540.0 27797.0 39101.0 True False 31427.597558385594 38744.93378998799 38604.44085940261 33445.40540599948 33093.19587458699 33075.26636973689 32189.354447802198 34640.50568159517 33357.17671307295 37972.05253340129 0.8276507447349861 1.0203539499453407 1.0166540464317817 0.8807900330533872 0.8715145394228369 0.8710423630811884 0.8477117327141462 0.9122631875410053 0.8784665164921236 1.0 15.21265036375076 -5.788904531696948 24.987454848585323 0.8869956787772495 0.9614330358188145 0.151182408117694 0.06322643825162945 302.1770677739776 274915.82394833973 0.01725942619419743 0.025606367065508458 1.6259061294819345e-06 5.788904531696948 0.07443735704156496 LLSPQMS(ph)GEEEDSDLAAK ddPTM_A459_Selumetinib_30min_R1 1 LLSPQMSGEEEDSDLAAK 18 0 P42858;A0A3B3IU44 P42858 HTT Huntingtin 1 LLSPQMS(1)GEEEDSDLAAK 153.04 7.9443e-05 6438600.0 1157.0 1683.6 1408.5 1629.3 1323.1 1174.7 1259.9 1095.7 753.65 1076.6 True False 1183.9558488699013 1486.4833293155946 1217.2334363366908 1344.7733407488774 1203.4258386122772 1162.8835845422623 1164.86472864869 1066.638476664803 1278.8890055818517 1214.792096972051 0.97461602838954 1.2236524529759056 1.0020096766934234 1.106998756495711 0.9906434538155912 0.957269632755124 0.9589004830968129 0.8780419952710175 1.0527636858764282 1.0 10.246493712622938 -6.393551523797741 3.9548274200338702 0.9619789030383193 1.0818556962506005 0.31654307847385854 0.0745320679617103 0.2534171598471069 6.841040976700312 0.022568276708162693 0.025672256634439682 4.040624345395332e-07 6.393551523797741 0.11987679321228117 LLSPS(ph)NEK ddPTM_A459_Selumetinib_30min_R1 1 LLSPSNEK 8 0 Q14694;Q14694-3;Q14694-2;H3BNA1;J3KT19 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 LLS(0.478)PS(0.522)NEK 96.492 0.021035 13970000.0 7036.9 7568.3 8355.5 9276.8 7169.6 6533.3 7755.4 7005.6 3582.8 5905.1 True False 7200.846078576159 6682.199917592789 7220.868993476195 7656.781027103166 6521.110945895688 6467.580933761781 7170.403934091635 6819.788730604127 6079.749922641355 6663.077105544916 1.0807088023315414 1.002869967095527 1.083713857590976 1.1491358880916003 0.9786936039609859 0.970659776453668 1.0761400206707092 1.0235194074114493 0.9124537846908413 1.0 12.701972873321962 -6.294140914195206 24.99631392394262 0.997735942472494 1.0739907000720421 0.3999240537306288 0.05102011864171694 779.686572145191 595972.9802531144 0.016570614187313808 0.018790713095191366 5.07994588374996e-07 6.294140914195206 0.07625475759954814 LLSPYS(ph)PQTQETDSAVQK ddPTM_A459_Selumetinib_30min_R2 1 LLSPYSPQTQETDSAVQK 18 0 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 LLS(0.042)PY(0.027)S(0.828)PQT(0.098)QET(0.004)DSAVQK 94.61 0.0042025 2813000.0 15772.0 12227.0 15304.0 19190.0 18451.0 13840.0 16923.0 11714.0 14237.0 18257.0 True False 14895.455380318459 13164.771583998428 14319.35730173532 16576.288895403555 16133.020425967154 15746.33437298885 17709.953032288337 11748.08580064291 17084.797815016715 17729.87297261727 0.8401332261840566 0.7425192275393417 0.8076401519543152 0.934935570097126 0.9099343492693738 0.8881244889519582 0.9988764758574582 0.6626153395902569 0.9636164817087615 1.0 14.113894579495492 -5.65419793580769 5.917923130940912 0.8969924537002995 0.7878815083783384 0.2253631158217113 0.09323586727756741 0.32139735455151164 15.579541010184482 0.024774706163874033 0.043313552890364745 2.217185675985908e-06 5.65419793580769 -0.10911094532196108 LLSSNEDDANILS(ph)SPTDR ddPTM_A459_Selumetinib_30min_R2 2 LLSSNEDDANILSSPTDR 18 0 H0YEG1;F5GY88;A0A0B4J1W0;O75448-2;O75448 H0YEG1 MED24 Mediator of RNA polymerase II transcription subunit 24 1 LLSSNEDDANILS(0.969)S(0.03)PT(0.001)DR;LLSSNEDDANILS(0.684)S(0.315)PT(0.001)DR 149.19 0.00017568 31079500.0 33351.0 27120.4 47599.8 42419.7 46911.8 34430.0 35053.0 35505.8 27153.1 33797.2 True False 31497.484934631073 29200.44747416952 44537.28069074366 36642.06368193592 41018.32028718689 39172.41997557847 36683.0339562018 35609.1159996984 32584.47872100372 32821.38702032864 0.9596634327221583 0.8896774367300073 1.3569591273872283 1.1164081414122096 1.2497436583585362 1.1935028812559378 1.1176564212073474 1.084936354994477 0.9927818925148353 1.0 15.002348587476863 -11.558817449517072 8.460460141159704 0.7694053704313627 1.1144962370909988 0.053128483995618425 0.13173483544755674 0.08625102961818903 0.0003663810111655239 0.01920019580448496 0.03230269908449685 2.7617384759616567e-12 11.558817449517072 0.34509086665963606 LLSSNEDDANILSS(ph)PTDR ddPTM_A459_Selumetinib_30min_R1 4 LLSSNEDDANILSSPTDR 18 0 H0YEG1;F5GY88;A0A0B4J1W0;O75448-2;O75448 H0YEG1 MED24 Mediator of RNA polymerase II transcription subunit 24 1 LLSSNEDDANILS(0.079)S(0.921)PTDR;LLSSNEDDANILS(0.457)S(0.543)PT(0.001)DR;LLSSNEDDANILS(0.025)S(0.974)PT(0.001)DR;LLSSNEDDANILS(0.008)S(0.991)PT(0.001)DR 334.98 1.1866999999999994e-144 171371000.0 9030.2 10447.1 11872.8 12448.8 10127.6 11114.199999999999 10924.6 9410.6 4873.490000000001 7934.2 True False 9240.586090289535 9223.948675274976 10260.538972622124 10274.850772917594 9211.560368173008 11002.401238886188 10100.548626554079 9161.000318063148 8269.956584373514 8952.631855652651 1.032164199229869 1.0303058166578152 1.1460919133119123 1.1476905270521205 1.0289220551783185 1.2289571844662999 1.1282211521047454 1.023274548285925 0.9237458568288945 1.0 13.128096146584914 -7.951539156892481 4.1194936926994465 0.9635823486890527 1.107563258463642 0.46786482344292135 0.06259894542196467 0.18858274113776893 6.69703027102009 0.04059432664977464 0.017361153347700966 1.1180490144184288e-08 7.951539156892481 0.14398090977458922 LLSSNEDDANILSS(ph)PTDR ddPTM_A459_Selumetinib_30min_R2 4 LLSSNEDDANILSSPTDR 18 0 H0YEG1;F5GY88;A0A0B4J1W0;O75448-2;O75448 H0YEG1 MED24 Mediator of RNA polymerase II transcription subunit 24 1 LLSSNEDDANILS(0.031)S(0.967)PT(0.001)DR;LLSSNEDDANILS(0.012)S(0.985)PT(0.003)DR;LLSSNEDDANILS(0.164)S(0.836)PTDR;LLSS(0.001)NEDDANILS(0.265)S(0.717)PT(0.017)DR 283.49 2.8183999999999992e-67 41867700.0 89083.4 73296.5 85942.0 98569.0 107137.4 73766.5 68062.4 77745.4 69173.3 80449.5 True False 84132.50125710505 78918.10586460635 80412.58528657461 85143.73215899077 93677.84199149166 83927.16578938445 71227.43646308708 77971.6262425562 83009.8928634892 78126.71390209622 1.0768723917216705 1.0101295948976152 1.029258511849646 1.0898158633126163 1.1990500727943478 1.0742441553929558 0.9116911860947473 0.9980149215064342 1.06250331951133 1.0 16.253528313631477 -7.047854041590384 22.72410764748578 0.9928982926356638 1.0808938485589357 0.352987256034871 0.057659798335458756 180.9965280851245 85947.46867321918 0.024110934997512486 0.018677241221581268 8.956657317964602e-08 7.047854041590384 0.0879955559232719 LLSSS(ph)LTADCSLR ddPTM_A459_Selumetinib_30min_R1 2 LLSSSLTADCSLR 13 0 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLS(0.001)S(0.159)S(0.837)LT(0.002)ADCS(0.001)LR;LLS(0.002)S(0.042)S(0.914)LT(0.042)ADCSLR 133.98 0.0012684 14510200.0 4190.0 4938.8 5428.5 5589.1 4459.7 5161.0 4974.9 4893.0 2793.9 4530.8 True False 4287.618847679246 4360.563000014168 4691.339516616068 4613.06860540082 4056.3209224239854 5109.08502581307 4599.6392876850305 4763.221745296052 4741.044241617641 5112.372313729303 0.8386749995036205 0.8529431607130517 0.9176443397945512 0.9023342437350269 0.7934322215795423 0.9993569936392535 0.8997074167178073 0.9317047845878508 0.9273667782147912 1.0 12.319777190511106 -1.5228787798122014 0.05220123615977643 1.1836528542448013 0.3760345204982488 0.4313268080899725 0.04701863486635273 440.00171531011387 1.7366923693811551 6.130426862063652 28.22557949779339 0.029999997614623446 1.5228787798122014 -0.8076183337465525 LLSSS(ph)LTADCSLR ddPTM_A459_Selumetinib_30min_R2 2 LLSSSLTADCSLR 13 0 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLSS(0.125)S(0.846)LT(0.029)ADCSLR;LLSS(0.03)S(0.964)LT(0.005)ADCSLR 160.48 0.00036396 9036900.0 45900.0 40481.0 47468.0 45742.0 50950.0 38479.0 43593.0 41014.0 39391.0 46261.0 True False 43349.06175225827 43585.76253306947 44413.96055925067 39511.86069064875 44549.20550122087 43779.132972416024 45620.160877890754 41133.343949766764 47270.30067649948 44925.324729487205 0.9649137098792223 0.9701824704777593 0.9886174630163352 0.8795008367455323 0.9916279018453157 0.9744867340642979 1.0154664691371165 0.9155936923649761 1.05219719525974 1.0 15.455241311418838 LLSSSLT(ph)ADCSLR ddPTM_A459_Selumetinib_30min_R1 1 LLSSSLTADCSLR 13 0 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLS(0.006)S(0.038)S(0.33)LT(0.626)ADCSLR 240.37 1.9416e-17 19656000.0 2773.8 3579.2 3587.8 4152.0 3445.8 3230.3 3377.2 3266.1 1767.2 2774.2 True False 2838.424143124747 3160.1456000750627 3100.5964663747104 3426.9311426927793 3134.1279984053995 3197.8061148777297 3122.45508500068 3179.4724182120212 2998.8093288187456 3130.295592996342 0.9067591410457779 1.009535842923431 0.9905123571434981 1.0947627918462792 1.0012242950530397 1.0215668200895898 0.9974952819110106 1.0157099621280836 0.9579955757303621 1.0 11.612083181569023 -4.760191901769629 6.155614646441197 1.0123390802237566 0.9030920794732462 0.4681406461271014 0.03288824879769259 0.11633301041216305 17.99292072767584 0.008150073259947333 0.05343213895512441 1.737033116056594e-05 4.760191901769629 -0.10924700075051041 LLSSSLTADCS(ph)LRSPSGR ddPTM_A459_Selumetinib_30min_R1 1 LLSSSLTADCSLRSPSGR 18 1 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLSSSLT(0.002)ADCS(0.879)LRS(0.118)PS(0.001)GR 159.64 7.141600000000001e-05 28531000.0 1168.5 1087.0 1530.6 1484.9 1510.0 1098.7 1163.7 1113.2 605.62 894.0 True False 1195.7237764947968 959.7335346674095 1322.752926983982 1225.59009002517 1373.4207666121536 1087.648075539783 1075.9211720997546 1083.674319816792 1027.6929072652845 1008.7536082974303 1.185347706971709 0.9514053052927793 1.3112745432618758 1.2149548511590609 1.3615027052346378 1.0782098488604273 1.0665847073555348 1.0742705759891282 1.0187749504061947 1.0 9.978358118674187 -6.9747442327576925 24.996768267387253 1.0498539263688533 1.1995401776014982 0.37307250729013697 0.10249575142369258 278.4223176677183 275566.2101434009 0.037820351586678784 0.033353383189022937 1.0598777307950213e-07 6.9747442327576925 0.1496862512326449 LLSSSLTADCS(ph)LRSPSGR ddPTM_A459_Selumetinib_30min_R2 1 LLSSSLTADCSLRSPSGR 18 1 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLSSSLT(0.024)ADCS(0.784)LRS(0.171)PS(0.02)GR 63.044 0.021809 5014400.0 5054.4 8305.8 8802.4 11385.0 8392.4 4890.2 5860.6 5517.3 2696.4 10373.0 True False 4773.496682366324 8942.828152643671 8236.063167328479 9834.343359779541 7338.071682992069 5563.780661184251 6133.129512558593 5533.354429561814 3235.755343710827 10073.504537709316 0.47386653418352487 0.8877573955684387 0.8175966106430459 0.9762583937859466 0.7284527103276338 0.552318276162651 0.6088377177574834 0.5492978544704247 0.3212144623152796 1.0 13.298278058881527 -6.625602186553604 4.609674229086215 0.5792494480260099 0.8038286394636334 0.1518443875212201 0.1981536451624555 0.3280980411669022 11.96780910277935 0.0645472148058571 0.06443069074084605 2.3680878711708325e-07 6.625602186553604 0.2245791914376235 LLSSSLTADCSLRS(ph)PSGR ddPTM_A459_Selumetinib_30min_R1 1 LLSSSLTADCSLRSPSGR 18 1 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLSSSLTADCSLRS(1)PSGR 238.45 3.0416e-24 23353000.0 1468.0 1482.7 1793.6 1759.6 1846.6 1427.2 1385.8 1271.5 961.5 980.31 True False 1502.2015437692448 1309.1047947114703 1550.0389715395731 1452.3188917828052 1679.5753560437088 1412.8436637939192 1281.267990286019 1237.7756895859247 1631.5952748184848 1106.142337528024 1.3580544680409963 1.183486745148026 1.4013015494945769 1.3129584163900705 1.518407983367834 1.2772711213199766 1.1583210829352768 1.1190021822617071 1.4750319370875256 1.0 10.111321327045856 -7.000673595494987 24.999816579869453 1.2008328411622993 1.3508026651286724 0.2490541429329194 0.13569950387919147 38.958695243589084 1445975.7209325936 0.04704003909192297 0.04101994317337387 9.984501912503925e-08 7.000673595494987 0.14996982396637315 LLSSSLTADCSLRS(ph)PSGR ddPTM_A459_Selumetinib_30min_R2 1 LLSSSLTADCSLRSPSGR 18 1 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLSSSLTADCS(0.003)LRS(0.831)PS(0.166)GR 56.339 0.035335000000000005 10702000.0 7267.2 8519.7 10500.0 11779.0 8627.8 7487.2 5211.6 5730.2 5808.8 11924.0 True False 6863.318116906563 9173.13359484677 9824.441431535603 10174.679880091631 7543.898630489368 8518.493837965474 5453.949726589484 5746.87393331432 6970.722311432824 11579.723137727357 0.5927014001349916 0.7921720999494548 0.8484176447644977 0.878663484357582 0.6514748704060932 0.7356388176684264 0.47099137533092 0.49628768019424385 0.6019765955130515 1.0 13.499313139560302 -6.421897973674113 5.4902697085672925 0.6250362071449876 0.7839135533562192 0.09990389734735605 0.15608543904885183 0.3992746591580439 17.64146780366904 0.04873563998955206 0.055091823229528325 3.785315005191252e-07 6.421897973674113 0.1588773462112315 LLSSSLTADCSLRSPS(ph)GR ddPTM_A459_Selumetinib_30min_R2 1 LLSSSLTADCSLRSPSGR 18 1 Q147X3;Q147X3-2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 LLSSSLTADCS(0.008)LRS(0.366)PS(0.626)GR 85.397 0.004207 3341500.0 6562.4 8595.7 9025.4 6914.7 8014.9 6163.7 5355.5 4468.7 5230.9 8624.6 True False 6197.68807936862 9254.962550468252 8444.715590112517 5972.905931477174 7007.996607884889 7012.693726502265 5604.54136172193 4481.703177166893 6277.226163557697 8375.585388598067 0.7399707353954885 1.1049929194283312 1.008253775504284 0.7131329518302408 0.8367172302278816 0.8372780410129724 0.6691521967349958 0.5350913362148952 0.7494671563020624 1.0 13.031974311861761 -5.762866698982057 24.999654121046646 0.745864798744898 0.966464547572936 0.2588524245404631 0.14311736585952695 44.22222046099677 774583.3584505422 0.04007001222732211 0.06326239165218622 1.726367696690335e-06 5.762866698982057 0.220599748828038 LLSTCGLVQSVELQEKPDLAES(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 LLSTCGLVQSVELQEKPDLAESPK 24 1 Q9Y3A4 Q9Y3A4 RRP7A Ribosomal RNA-processing protein 7 homolog A 1 LLSTCGLVQSVELQEKPDLAES(1)PK 88.708 3.9714e-05 9409600.0 754.69 1230.0 997.08 1192.6 886.45 1013.3 1090.3 773.87 786.67 1007.1 True False 772.2728086288905 1085.991028188513 861.6820125683976 984.3347978746157 806.2707540154589 1003.107122002787 1008.0577931944337 753.344453715973 1334.9215338964718 1136.371094984722 0.6795956110088082 0.9556658322104836 0.7582751940553208 0.8662089366923308 0.7095136065796348 0.8827284734977119 0.8870850355516887 0.6629387680140715 1.1747232394312346 1.0 10.150218325022212 -8.268864055465636 24.965655411917208 1.0873616385844853 0.8088503807821088 0.5625290612104363 0.10104958985302656 426.7119911568228 1434809.6371742203 0.08359714498177563 0.023307083638815007 5.384383001740655e-09 8.268864055465636 -0.2785112578023765 LLT(ph)PTHSFLAR ddPTM_A459_Selumetinib_30min_R1 2 LLTPTHSFLAR 11 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LLT(1)PTHSFLAR;LLT(1)PTHSFLAR 145.81 0.00094257 50188000.0 7986.200000000001 8653.1 10025.6 10576.4 9585.8 7177.8 8931.8 7747.3 5514.4 7683.8 True False 8172.2629215599045 7639.991029282948 8664.178586678832 8729.430283616548 8718.766082510447 7105.597848920953 8258.067134966559 7541.816437222989 9357.534044159174 8670.090576550105 0.9425810318133621 0.8811892980618616 0.9993181167118066 1.0068441853683672 1.0056141865567119 0.8195528969604288 0.9524776081696377 0.8698659339985737 1.0792890756491507 1.0 13.081831350041963 -8.270784673552505 24.993968441456502 1.039644540479953 0.9365775348850216 0.3149212398202915 0.06187498840674149 942.7034783447693 2521228.1939775203 0.058094098659010635 0.01583143339248473 5.360623753645393e-09 8.270784673552505 -0.10306700559493143 LLT(ph)PTHSFLAR ddPTM_A459_Selumetinib_30min_R2 1 LLTPTHSFLAR 11 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LLT(1)PTHSFLAR 126.5 0.004266300000000001 16220000.0 24287.0 22894.0 26793.0 29717.0 27000.0 28105.0 20080.0 24029.0 17536.0 23119.0 True False 22937.2257685642 24649.896184187448 25069.16755001271 25669.49333531566 23608.018616937443 31976.208638211825 21013.759787765146 24098.920411784904 21043.689996778336 22451.494399624167 1.0216347010267683 1.0979178376919125 1.1165923792775398 1.1433311688929428 1.0515121263969243 1.4242352009649344 0.9359626318734895 1.0733771205977414 0.9372957372998121 1.0 14.45452385530311 LLTPTHS(ph)FLAR ddPTM_A459_Selumetinib_30min_R1 1 LLTPTHSFLAR 11 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LLT(0.001)PT(0.22)HS(0.778)FLAR 126.09 0.0021338 6755200.0 2746.6 2941.5 3652.0 3849.1 2713.5 3117.0 2683.4 3303.0 1445.5 2262.9 True False 2810.590436046735 2597.107812533751 3156.078459000068 3176.9269415555796 2468.064404107334 3085.64581000956 2480.9889775822644 3215.393710343931 2452.907924857119 2553.3652575125884 1.1007396719984854 1.017131334771812 1.236046605441254 1.24421170539872 0.96659277275185 1.2084623619479742 0.9716545528621977 1.259276831187196 0.9606568890369676 1.0 11.318184213911206 -7.25147051293417 24.973497134338114 1.069503466606784 1.1265243461173045 0.09418847460810742 0.1153411126518165 2350.770690184998 5889031.7347419 0.04349342384163133 0.0332749595058434 5.60440468006445e-08 7.25147051293417 0.057020879510520484 LLTPTHS(ph)FLAR ddPTM_A459_Selumetinib_30min_R2 2 LLTPTHSFLAR 11 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LLTPT(0.124)HS(0.876)FLAR;LLTPT(0.379)HS(0.621)FLAR 98.253 0.012192 5129200.0 59149.0 46739.0 57188.0 62391.0 53858.0 41648.0 40380.0 46020.0 35698.0 43477.0 True False 55861.73537220752 50323.73101042794 53508.586341586466 53893.23816952179 47091.876543371 47384.63395709824 42257.750011452066 46153.910580978845 42838.59748545807 42221.70604318789 1.3230572756834473 1.1918924109545128 1.2673241172882357 1.2764344035363062 1.1153475535830193 1.1222813665707698 1.0008536833691017 1.0931322986752066 1.0146107654114964 1.0 15.365697254073444 -6.572157977759206 1.4111244328181858 1.0358842372034296 1.2641273894808354 0.8378073414586422 0.045711100556514214 0.15622160345536423 0.6435344050016027 0.018659956046704108 0.019874020325446235 2.678193935192839e-07 6.572157977759206 0.22824315227740577 LLVDSQGLSGCS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LLVDSQGLSGCSPR 14 0 O94885;A0A087WW74 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 LLVDSQGLS(0.022)GCS(0.978)PR 79.471 0.035968 16422000.0 1949.0 2681.5 2226.5 3026.6 3282.4 2374.9 2448.0 2724.0 1157.7 1798.8 True False 1994.4079079061687 2367.5487334044715 1924.1535292890624 2498.061126318392 2985.50749955479 2351.010662236673 2263.345389103892 2651.7506712009904 1964.5323449374503 2029.6935017957692 0.9826153092285207 1.1664562808669314 0.948002014878931 1.2307578085598812 1.470915434726162 1.1583082175494077 1.1151168327145944 1.3064783765897938 0.9678960607595838 1.0 10.987046171272523 -5.777674555976806 24.890246296976645 1.199968231422888 1.0457676903115822 0.15942936805986485 0.14717235697596548 371.5985554927901 569699.0575844719 0.0411733027729849 0.06128164663633095 1.6684970534179146e-06 5.777674555976806 -0.15420054111130588 LLVDSQGLSGCS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LLVDSQGLSGCSPR 14 0 O94885;A0A087WW74 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 LLVDSQGLS(0.007)GCS(0.993)PR 101.3 0.0083845 7306100.0 21353.0 20745.0 23114.0 28875.0 32322.0 22475.0 23445.0 19654.0 19162.0 23038.0 True False 20166.285742831602 22336.07479431155 21626.870404620375 24942.17518784668 28261.42139765379 25570.727242263336 24535.238955386165 19711.189886105145 22994.935431014263 22372.83308008745 0.9013738077177295 0.9983570124693498 0.9666576569540043 1.114842054136006 1.26320262152259 1.142936486886952 1.096653198437498 0.8810323581079567 1.027806149927454 1.0 14.44946033651847 -5.748203524645356 22.287689020763533 1.0818017770440738 0.9597519687815936 0.2427458074232638 0.09634179420639614 102.5355476162267 172651.53791134973 0.029568601112894534 0.050689303711860145 1.7856505642924878e-06 5.748203524645356 -0.12204980826248013 LLVDVDEST(ph)LSPEEQKER ddPTM_A459_Selumetinib_30min_R1 1 LLVDVDESTLSPEEQKER 18 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LLVDVDES(0.039)T(0.566)LS(0.395)PEEQKER 93.851 0.0061713 7078500.0 1363.1 1878.4 1909.0 1801.7 1342.0 1644.2 1703.9 1699.2 730.55 1580.8 True False 1394.8575778691115 1658.476054755532 1649.7682853863994 1487.0669170976832 1220.6163369493433 1627.6608408141547 1575.37345118224 1654.1316962205287 1239.6899927390996 1783.711078295949 0.7819974853784477 0.9297896250888014 0.924907797827039 0.8336927068470854 0.6843128081681521 0.9125137252436222 0.8831999029165966 0.9273540520927792 0.6950060510491561 1.0 10.800666234188185 -5.797369861750849 24.962971409898515 0.8423174109159409 0.8839875568654167 0.01676835626491091 0.09980415007239427 693.5100406373929 481818.2425827642 0.027817008852658982 0.04126075110180249 1.5945206142371931e-06 5.797369861750849 0.04167014594947582 LLYNS(ph)PEYEASFPR ddPTM_A459_Selumetinib_30min_R1 3 LLYNSPEYEASFPR 14 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 LLYNS(0.939)PEYEAS(0.061)FPR;LLY(0.225)NS(0.768)PEY(0.001)EAS(0.006)FPR;LLYNS(0.966)PEYEAS(0.034)FPR 188.19 6.9262e-05 28341500.0 4569.76 5760.799999999999 5844.4 6148.9 5603.3 5016.43 5410.2 4493.1900000000005 2696.26 4255.53 True False 4676.226516794918 5086.322857876736 5050.76258099124 5075.110044148272 5096.482504342963 4965.969268754014 5002.104258222989 4374.0160052619585 4575.356292961089 4801.768727872443 0.9738550067293328 1.0592602738971086 1.051854611754515 1.0569251315018957 1.0613760872654732 1.0341958453618243 1.0417211951895298 0.9109176749543262 0.952848117486976 1.0 12.229350204018324 -7.746159877304691 24.994346086785562 0.9489121815942156 1.0423529583678544 0.607566499906311 0.031270298386237884 132.82604637561988 217278.77521098487 0.014312233496489609 0.008224473961501473 1.7940730511676683e-08 7.746159877304691 0.09344077677363871 LMEDLDR ddPTM_A459_Selumetinib_30min_R2 1 LMEDLDR 7 0 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 0 133.81 0.042994 66539000.0 128620.0 126980.0 139210.0 139690.0 151580.0 97234.0 109910.0 111260.0 104220.0 121500.0 False True 121471.81530665483 136718.95769494752 130253.38016038781 120663.98102130926 132537.16525760648 110627.10089762993 115021.03278253334 111583.74817991552 125066.91215010463 117991.97930508846 1.0294921402459793 1.1587139947999112 1.1039172402015174 1.0226456216088373 1.1232726668217756 0.9375815335005494 0.9748207756149828 0.9456892649575497 1.0599611336862373 1.0 16.848329267837002 -6.7589953548657355 24.999999819169968 0.9796667567924223 1.0888556635083413 0.5288855642182612 0.048999112767664416 49.80238215078396 509431.27680761064 0.016275268404046906 0.015548540089416195 1.7418255035386607e-07 6.7589953548657355 0.10918890671591897 LMELHGEGS(ph)SSGK ddPTM_A459_Selumetinib_30min_R1 3 LMELHGEGSSSGK 13 0 D6RAT0;P61247;D6RG13;D6R9B6;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 1 LMELHGEGS(0.952)S(0.039)S(0.01)GK;LMELHGEGS(0.951)S(0.046)S(0.002)GK;LMELHGEGS(0.753)S(0.232)S(0.015)GK 128.95 0.0017746 20430600.0 6325.799999999999 8230.8 7265.700000000001 7287.6 9335.099999999999 6687.7 8321.3 7802.5 3048.6400000000003 5666.0 True False 6473.178832135887 7267.134109604889 6279.057847633295 6014.957465194574 8490.741853245763 6620.4278099457615 7693.617641482932 7595.5523539081205 5173.319416144175 6393.2862915136875 1.0124963183219633 1.1366821034201344 0.9821330629238335 0.9408240443070258 1.3280715841735717 1.0355281318675775 1.2033901331300112 1.188051341293803 0.8091800023113511 1.0 12.642341983868967 -4.71205455106345 21.94784247133865 1.0796743172108052 1.0124928222683267 0.009502906559406554 0.1422181519778265 17924.965007477025 7963390.017399219 0.03461976275420531 20.709808138386155 1.9406421012064783e-05 4.71205455106345 -0.06718149494247849 LMELHGEGS(ph)SSGK ddPTM_A459_Selumetinib_30min_R2 2 LMELHGEGSSSGK 13 0 D6RAT0;P61247;D6RG13;D6R9B6;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 1 LMELHGEGS(0.478)S(0.478)S(0.044)GK;LMELHGEGS(0.686)S(0.157)S(0.157)GK 145.0 0.00063953 16054500.0 60115.0 58701.0 64832.0 69107.0 75555.0 56044.0 66501.0 64225.0 56188.0 63381.0 True False 56774.04895941187 63203.17794653564 60660.77970374438 59694.50738377559 66063.10542973 63763.55228322158 69593.4282692316 64411.88411697891 67427.17002389263 61551.02584638524 0.9223899712265493 1.0268419912979798 0.9855364532044897 0.9698377332127166 1.0733063262764408 1.035946215459645 1.1306623620363052 1.0464794571861986 1.095467851212954 1.0 15.909495281282082 -6.263520972409521 24.984100641171175 1.067933736180497 0.98044263281808 0.5246016860291574 0.040597754222857746 143.81968289912655 1726175.0238129052 0.011742107582208717 0.013974577641283884 5.45103571588908e-07 6.263520972409521 -0.08749110336241706 LMELHGEGSS(ph)SGK ddPTM_A459_Selumetinib_30min_R2 1 LMELHGEGSSSGK 13 0 D6RAT0;P61247;D6RG13;D6R9B6;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 1 LMELHGEGS(0.061)S(0.47)S(0.47)GK 121.13 0.0012284000000000002 0.0 33826.0 25653.0 30379.0 39033.0 37664.0 35278.0 40234.0 40071.0 36345.0 32715.0 True False 31946.0863362067 27620.50261260422 28424.448214154298 33716.63806431927 32932.31159956787 40137.22427820089 42104.96072215855 40187.59997588886 43615.015564148525 31770.432946221958 1.0055288321151328 0.8693775958092119 0.8946824320042653 1.061258375716556 1.0365710676751756 1.2633515050343023 1.3252875965974376 1.2649371207472904 1.372817790616073 1.0 14.955397129818403 -6.503477772589573 1.5680964648073146 1.2712628252730684 0.9305756678852628 0.6209703905090109 0.10627527253593619 0.22336481083553508 1.1167188610951915 0.04022264697690401 0.044961326143315744 3.1370556821403663e-07 6.503477772589573 -0.34068715738780564 LMELHGEGSSS(ph)GK ddPTM_A459_Selumetinib_30min_R1 2 LMELHGEGSSSGK 13 0 D6RAT0;P61247;D6RG13;D6R9B6;H0Y9Y4 D6RAT0 RPS3A 40S ribosomal protein S3a 1 LMELHGEGS(0.045)S(0.326)S(0.63)GK;LMELHGEGS(0.066)S(0.314)S(0.62)GK 115.1 0.0026920000000000004 23295000.0 15444.8 19745.1 16927.9 18235.8 18404.9 16935.4 19739.1 19715.9 6612.8 14458.1 True False 15804.63378965069 17433.33451275204 14629.184158298807 15051.259858361505 16740.180044649012 16765.045252112905 18250.163794959415 19192.970285731117 11221.438620197274 16313.937968819992 0.9687810398603508 1.0686159617666497 0.8967291763802725 0.9226012681382153 1.026127479253855 1.0276516488020913 1.1186853738098081 1.1764768458978865 0.6878436488874878 1.0 13.993817451135648 LMHNAS(ph)DSEVDQDDVVEWK ddPTM_A459_Selumetinib_30min_R2 2 LMHNASDSEVDQDDVVEWK 19 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 LMHNAS(0.5)DS(0.5)EVDQDDVVEWK;LMHNAS(0.627)DS(0.373)EVDQDDVVEWK 80.314 0.0042307 3227000.0 33510.6 27602.8 29820.6 29472.0 38914.0 25104.6 25827.3 30473.9 27284.6 27915.5 True False 31648.215005560476 29719.846003009076 27901.975062214347 25457.862757964245 34025.27542442607 28562.5307731312 27028.320625824064 30562.57400377426 32742.28239542072 27109.506981820537 1.1674212676307085 1.0962886939603518 1.0292321096405492 0.9390750918132198 1.2551049138312698 1.0535983111860001 0.9970052440993886 1.1273747628191588 1.2077786002297086 1.0 14.726511255862285 -6.2340524806730775 24.997323435299116 1.1050282678568168 1.0586837796924142 0.0612253393002995 0.09345403890659944 2700.9513317405717 2465289.1855373196 0.02838770371895705 0.036640147405982544 5.833746043179036e-07 6.2340524806730775 -0.04634448816440262 LMHNASDS(ph)EVDQDDVVEWK ddPTM_A459_Selumetinib_30min_R2 1 LMHNASDSEVDQDDVVEWK 19 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 LMHNAS(0.11)DS(0.89)EVDQDDVVEWK 96.881 0.0029302 0.0 10896.0 8828.9 11770.0 13547.0 13563.0 10441.0 9737.4 10782.0 10054.0 11114.0 True False 10290.44394014393 9506.048240612066 11012.731014207055 11701.875230121523 11859.094685241575 11879.152976038773 10190.208394292049 10813.37383494381 12065.080932231367 10793.109942360094 0.9534271396381008 0.8807515434734291 1.0203482659789285 1.0841986501216638 1.0987653001381719 1.1006237349085317 0.9441401457700513 1.0018774841257 1.117850276395233 1.0 13.397823004519621 -5.3907639538993575 4.854327256325113 1.0496280341425444 0.9183361759827398 0.4790844368227548 0.054349469437941 0.18970281543114959 6.589456332261017 0.015146532481909994 0.032707877713760936 4.066642977568141e-06 5.3907639538993575 -0.1312918581598046 LMHQAALLGQALQDSR ddPTM_A459_Selumetinib_30min_R1 1 LMHQAALLGQALQDSR 16 0 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225;E9PIZ5 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 97.291 0.01082 5309200.0 1297.8 1956.3 1448.5 1378.4 1559.8 1479.2 1631.9 1641.4 1012.4 1375.7 False True 1328.036214920794 1727.2554865408033 1251.8016560409637 1137.6883157725738 1418.7163654050566 1464.3205910061415 1508.8044691497723 1597.8647399813883 1717.968857229571 1552.2844954527675 0.8555366099520532 1.112718378364657 0.8064254070100987 0.7329122458578283 0.9139538335666028 0.9433326141539738 0.9719896536811617 1.029363331697342 1.1067358221138948 1.0 10.600177276829386 -7.39697317806201 1.5109585227908175 1.05412461805701 0.8870310373766034 0.35010184645152065 0.09479192604902598 0.5077296691014727 2.241467083436098 0.06423745569732776 0.03409428374477463 4.008914758379613e-08 7.39697317806201 -0.1670935806804067 LMIEMDGTENK ddPTM_A459_Selumetinib_30min_R2 2 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 ; 182.64 0.00048953 10018100.0 73656.0 64835.0 73066.0 69739.0 67477.0 51887.0 64488.0 65794.0 52659.0 64213.0 False True 69562.49438832968 69807.63602261695 68365.0131082457 60240.427893514796 58999.9360079662 59033.96326671041 67486.81978054775 65985.4496472169 63192.271415394076 62359.003844589606 1.115516446697778 1.1194475812440934 1.0963134253815887 0.9660261418486623 0.9461333948663638 0.9466790619977538 1.082230562065065 1.0581543254229184 1.013362425943832 1.0 15.928310261402508 -5.6607403041468105 5.812331111096398 1.0031818774756165 1.1146945587172168 0.5900570662504178 0.04163471942757639 0.16665900976348297 8.098194907931997 0.013153570436712541 0.02299698711276333 2.184035513095344e-06 5.6607403041468105 0.1115126812416003 LMLSTSEYSQS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 LMLSTSEYSQSPK 13 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LMLSTSEYSQS(1)PK;LMLS(0.003)T(0.175)S(0.001)EYS(0.041)QS(0.78)PK 204.35 4.0213e-05 61596000.0 5654.8 7102.599999999999 7404.4 7530.299999999999 5764.1 5786.5 5964.1 5333.4 4022.2000000000003 6359.1 True False 5786.54583767461 6271.0242900908415 6398.923149457857 6215.274466237819 5242.738172734509 5728.293063721632 5514.223135275545 5191.9409066752405 6825.379630135113 7175.352427879404 0.8064476129689925 0.8739674257288256 0.8917921751961928 0.8661977970710876 0.7306593265529596 0.798329158225691 0.7684950935441666 0.7235799159498095 0.9512256991887266 1.0 12.808833978257681 -8.433922841287604 5.548433320283629 0.9989443005875185 0.8106822544178798 0.6085102885608593 0.05453447003644352 0.15008867995571823 6.69235158446664 0.058407408751395704 0.015166144168371917 3.681943829032015e-09 8.433922841287604 -0.1882620461696387 LMLSTSEYSQS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 LMLSTSEYSQSPK 13 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LMLST(0.011)SEYS(0.025)QS(0.964)PK 178.68 0.00010741 9522300.0 52703.0 45758.0 50080.0 46295.0 44067.0 35277.0 46744.0 43172.0 30307.0 43244.0 True False 49773.97824682498 49267.49146484011 46857.90732298123 39989.54113667055 38530.909496021595 40136.086537278 48917.6886214788 43297.623372490656 36369.24684833264 41995.433358594564 1.1852235889986 1.1731630685686754 1.1157857789647392 0.9522354679663403 0.917502366674258 0.9557250235891175 1.1648335237733072 1.0310078956151454 0.8660286116773576 1.0 15.3579448353193 -5.603168927335057 4.015807819283809 0.9891446192591544 1.173303793520231 0.5399364682177226 0.07484425615663966 0.18371736990448997 5.6800879643975755 0.022468881163389146 0.041477321977867486 2.4936245942091877e-06 5.603168927335057 0.18415917426107664 LMMEHFEK ddPTM_A459_Selumetinib_30min_R1 1 LMMEHFEK 8 0 O75132 O75132 ZBED4 Zinc finger BED domain-containing protein 4 0 72.789 0.036662 1481000.0 1322.5 1082.3 1551.7 1523.3 1302.4 1167.1 1025.5 1111.3 874.54 1073.3 False True 1353.31167686296 955.5838128523808 1340.9876628779862 1257.284250882444 1184.5981499573952 1155.3600336420145 948.1457093652135 1081.8247139888615 1484.0305061255924 1211.0685098273289 1.1174526179827033 0.7890419122437802 1.1072764686691265 1.038161128524186 0.9781429707278015 0.9540005575793089 0.7829001428667299 0.8932811853419468 1.2253893929891562 1.0 10.242064764882144 -4.46132273862668 21.929267234786092 0.9695540205896697 4.42861301877351 0.10040083150694601 0.12791036800278044 679.4903797777398 254631.6256254572 0.030767304150799937 5895.993630979539 3.4568239430463125e-05 4.46132273862668 3.4590589981838407 LMMNDNDIS(ph)SSTSR ddPTM_A459_Selumetinib_30min_R1 1 LMMNDNDISSSTSR 14 0 Q9NYK1 Q9NYK1 TLR7 Toll-like receptor 7 1 LMMNDNDIS(0.246)S(0.246)S(0.246)T(0.246)S(0.018)R 103.11 0.027002 9072600.0 0.0 126.72 164.27 110.94 150.77 157.38 140.99 149.16 0.0 200.58 True False 0.0 111.88356348947028 141.96303627052063 91.56641160171888 137.13288012060545 155.79690008960682 130.35501078829984 145.20379226003658 0.0 226.32639681465156 0.0 0.49434606419814364 0.627249133413193 0.4045768098217309 0.6059075832542391 0.6883726435904673 0.5759602619178936 0.641568081777709 0.0 1.0 7.8222610480547035 -4.786419743863284 5.003648136035037 0.5549382227958486 6.709742756199995e-11 0.3356442738828014 0.23731263838965103 0.18112085914999515 11.085897195717443 0.05563227318252804 0.32847051807075806 1.6352353091092848e-05 4.786419743863284 -0.5549382227287512 LMPS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 LMPSPLK 7 0 Q8NI77 Q8NI77 KIF18A Kinesin-like protein KIF18A 1 LMPS(1)PLK 101.46 0.019909 14472000.0 8509.4 10830.0 6438.6 7783.1 7003.9 6686.0 8370.8 7112.6 4812.4 7803.9 True False 8707.65246358993 9562.018565269596 5564.273484698204 6423.927691881544 6370.39848163898 6618.744910402283 7739.383816630259 6923.950743019145 8166.291316210577 8805.606581423175 0.9888759375146403 1.0859011786243316 0.6319012135333097 0.7295269931129832 0.7234480013084331 0.7516512178008924 0.8789154665344371 0.7863116162407617 0.9273967943830996 1.0 13.104206673371497 -10.38476912348847 14.313308241198545 0.9999999801672378 0.8264541453927641 0.12437193860536777 0.13103361885264167 0.0 0.0 0.13561200589399258 0.03289074261193037 4.1231665366121637e-11 10.38476912348847 -0.17354583477447372 LMPS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 LMPSPLK 7 0 Q8NI77 Q8NI77 KIF18A Kinesin-like protein KIF18A 1 LMPS(1)PLK 81.525 0.042863 15123000.0 237070.0 230650.0 238020.0 239130.0 245550.0 208590.0 252260.0 230730.0 207570.0 202690.0 True False 223894.59846640265 248340.11334335816 222706.05233658163 206560.08147774075 214701.81375514777 237321.37910850768 263990.58984370716 231401.3861005921 249089.7999903781 196837.81304813467 1.1374572547788444 1.2616484073750054 1.1314190545396943 1.0493922802689775 1.090754923712979 1.2056696598761396 1.341157909426432 1.1755941732801372 1.2654570589517051 1.0 17.586647867150717 -6.888475026375072 7.4227696346960945 1.2189326031185 1.1366390728593365 0.0788745581149608 0.0960768880725628 0.4672861117466932 28.773419442075525 0.033785735662860486 0.02980406937731299 1.2927810386163998e-07 6.888475026375072 -0.08229353025916342 LMPVSLS(ph)VQSPAALTAEK ddPTM_A459_Selumetinib_30min_R2 1 LMPVSLSVQSPAALTAEK 18 0 P54198 P54198 HIRA Protein HIRA 1 LMPVS(0.003)LS(0.627)VQS(0.369)PAALT(0.001)AEK 125.45 0.00082511 2896000.0 15588.0 11531.0 11035.0 17155.0 14868.0 14879.0 13007.0 12275.0 11231.0 13354.0 True False 14721.681363708098 12415.390621991157 10325.020113999557 14818.459405974361 13000.148918393561 16928.44719188592 13611.851272881551 12310.718217764355 13477.513820359107 12968.435322141155 1.135193336591162 0.9573545546234264 0.796165447682924 1.142655920924758 1.0024454450721794 1.3053577221443047 1.0496140000514853 0.9492832336331376 1.0392551981462865 1.0 13.662716804462113 -4.729091175853683 23.10958129494208 1.0303724026050343 1.135195137313415 0.06233204168293338 0.12535390738127078 5764.391340008326 4117483.779464449 0.032761016189342664 4.068943425042404 1.865987903908241e-05 4.729091175853683 0.10482273470838077 LMPVSLSVQS(ph)PAALTAEK ddPTM_A459_Selumetinib_30min_R2 1 LMPVSLSVQSPAALTAEK 18 0 P54198 P54198 HIRA Protein HIRA 1 LMPVSLSVQS(0.998)PAALT(0.002)AEK 209.73 1.2953e-11 3726000.0 36683.0 33141.0 28730.0 33343.0 36311.0 30076.0 30695.0 32778.0 24806.0 31963.0 True False 34644.305713683876 35682.80813488933 26881.543078858853 28801.625880116753 31749.287555541305 34218.69599725526 32122.378320988617 32873.37855331 29767.89313755037 31040.1451401526 1.1161128776060085 1.1495696290650113 0.866025044582852 0.9278830930097629 1.0228459761443376 1.1024012884846657 1.0348655966635953 1.0590600786458948 0.9590126915690068 1.0 14.921847682966527 -6.869545858133665 0.005791460266565601 1.2055552800081717e-07 2.0475853972966975 0.036096792458876314 0.08257587230830524 39289.18816484136 96.60987671265035 16831.365403673517 17319.51507249071 1.3503742312664918e-07 6.869545858133665 2.0475852767411697 LMQNST(ph)SPPLK ddPTM_A459_Selumetinib_30min_R1 2 LMQNSTSPPLK 11 0 Q9Y2Q0-3;Q9Y2Q0-2;Q9Y2Q0 Q9Y2Q0-3 ATP8A1 Phospholipid-transporting ATPase IA 1 LMQNS(0.125)T(0.437)S(0.437)PPLK;LMQNS(0.128)T(0.436)S(0.436)PPLK 129.42 0.006053 14765200.0 3890.5 4817.3 3608.7 4024.3999999999996 3403.8 3446.3 4445.9 3443.3 2111.0 3763.7999999999997 True False 3981.1410804047987 4253.288276497987 3118.6583611701944 3321.6140873441263 3095.9268909897 3411.633350990037 4110.542183585373 3351.972498585304 3582.2128186602404 4246.92039251663 0.9374183437532398 1.001499412136987 0.7343340757376775 0.7821229927448232 0.7289816160540562 0.8033193551264989 0.9678877406858002 0.7892713281114742 0.8434848048888199 1.0 12.052201350635398 -9.91209480025104 14.652373772077773 1.0000276283850749 0.8403639860234507 0.2107159351633765 0.09092819918162075 0.0 0.0 0.09397312971242981 0.02279183175142456 1.2243489123018042e-10 9.91209480025104 -0.15966364236162411 LMS(ph)DVEDVSLENVHTR ddPTM_A459_Selumetinib_30min_R1 2 LMSDVEDVSLENVHTR 16 0 Q9NSI6-3;Q9NSI6-2;Q9NSI6 Q9NSI6-3 BRWD1 Bromodomain and WD repeat-containing protein 1 1 LMS(1)DVEDVSLENVHTR;LMS(1)DVEDVSLENVHTR 198.88 5.9107e-07 6225800.0 4999.4 5405.4 5999.5 5761.1 5514.9 5483.4 5361.9 5940.7 2914.3 5047.3 True False 5115.876292861006 4772.533255097715 5184.800852894555 4755.032034240692 5016.078268734677 5428.24197452885 4957.447566109543 5783.133337886823 4945.354247949565 5695.170119865349 0.8982833146662809 0.8379966102242704 0.910385597580207 0.834923616707189 0.8807600410807873 0.9531307863121725 0.8704652296192957 1.0154452309887372 0.8683417955680819 1.0 12.475523221840502 -7.904668154955997 0.3179902994178666 1.0031786821231374 0.8533732584853035 0.34987222613147606 0.048444847542311084 1.4733887337922402 0.5095912300343448 0.07807196668461389 0.07336514448883089 1.2454659105907775e-08 7.904668154955997 -0.1498054236378339 LMS(ph)MRKDMRT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 LMSMRKDMRTK 11 3 B5MCA1;Q96G28;Q96G28-2 B5MCA1 CFAP36 Cilia- and flagella-associated protein 36 2 LMS(1)MRKDMRT(1)K 72.848 0.029006 5094100.0 754.4 950.66 1838.9 1822.4 1329.0 1139.6 1254.8 1140.3 711.34 704.66 True False 771.9760521931322 839.3562852501567 1589.1874803546627 1504.1520506848067 1208.7921846540069 1128.1366586740123 1160.1494257547242 1110.055539783586 1207.0920257819866 795.10997496965 0.9709047509089533 1.0556480382253985 1.9987014757490915 1.8917534656035744 1.5202830082720915 1.4188435489280262 1.45910561089239 1.396103148908373 1.5181447394469707 1.0 9.635010609128125 -10.443319446591667 0.6743980659115627 0.908770601628187 1.488334383762267 0.17934329716417996 0.2990831152857599 59.86865100903416 15.275906194991713 11.958585638198603 0.12156861036491502 3.603135158529523e-11 10.443319446591667 0.5795637821340799 LMSLLTSPHQPPPPPPASASPSAVPNGPQS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 LMSLLTSPHQPPPPPPASASPSAVPNGPQSPK 32 0 Q96RU3-5;Q96RU3-2;Q96RU3 Q96RU3-5 FNBP1 Formin-binding protein 1 1 LMSLLTSPHQPPPPPPAS(0.002)AS(0.043)PS(0.024)AVPNGPQS(0.932)PK;LMSLLTSPHQPPPPPPAS(0.078)AS(0.102)PS(0.095)AVPNGPQS(0.725)PK 147.49 1.1835e-20 31969000.0 4710.8 5021.4 6385.1 6474.799999999999 5258.2 5524.4 5259.9 4409.0 1780.23 3578.4 True False 4820.552474378851 4433.49215361447 5518.038490843737 5344.097727048937 4782.596738410611 5468.829551753872 4863.141508230217 4292.05899754962 3020.9202871452003 4037.722496567698 1.1938790935921437 1.0980180429396027 1.3666215287292267 1.3235425989754706 1.184478810140147 1.3544342278110244 1.2044268798472837 1.062990089387798 0.7481743209725682 1.0 11.979326045608104 -7.935883764357902 2.9304400081583704 0.8761438585155193 1.2514463676417955 0.6982048960878589 0.0981208883889091 0.1414844691389626 2.384946100926298 0.0684145025500767 0.026670905690142546 1.1590875356803301e-08 7.935883764357902 0.37530250912627616 LMT(ph)PTLSFLAR ddPTM_A459_Selumetinib_30min_R1 2 LMTPTLSFLAR 11 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 LMT(0.992)PT(0.004)LS(0.004)FLAR;LMT(0.998)PT(0.001)LSFLAR 158.56 0.0013444000000000002 3505400.0 3068.6000000000004 3364.5 2949.8 3001.9 2782.3 2571.8 2987.5 2819.0 2113.9 2803.3 True False 3140.092409543803 2970.582775886383 2549.2333620915656 2477.674517641968 2530.6414562549617 2545.9300270075687 2762.150469749951 2744.230962597498 3587.133906852621 3163.1308614543445 0.9927165669333236 0.9391273728462085 0.8059209288987427 0.7832981391426793 0.8000432378859669 0.8048766043896777 0.8732330689853183 0.8675679517526365 1.1340453695941395 1.0 11.627137527291312 -8.228083799974558 10.568236546118815 1.0669349652170403 0.8534964203907429 0.5879408624900273 0.06978416802373222 0.46968973348975435 148.45519837963278 0.05138752706062175 0.019172960389683694 5.914474994821666e-09 8.228083799974558 -0.21343854482629743 LMTGVIS(ph)PERR ddPTM_A459_Selumetinib_30min_R2 1 LMTGVISPERR 11 1 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 LMTGVIS(1)PERR 68.033 0.037534 3800700.0 12649.0 13538.0 10600.0 14926.0 16321.0 10957.0 11924.0 14673.0 11968.0 13176.0 True False 11946.019217958925 14576.321068469017 9918.007540407374 12893.05305121383 14270.610068408752 12466.227292257145 12478.489626957757 14715.696000754084 14361.934413859668 12795.574644640694 0.9336055276706469 1.13916892935904 0.7751123193643701 1.0076181343378716 1.1152769973004584 0.9742608392721547 0.975219165493615 1.150061361794143 1.122414179333089 1.0 13.643357319295488 -7.751165415256156 24.98426675699688 1.1021783310502984 0.9912393327935463 0.17518347843286186 0.10062650164435445 321.73385666165166 782398.2849151884 0.04753316333622642 0.027057939660683237 1.7735138514810337e-08 7.751165415256156 -0.11093899825675213 LNAS(ph)PAAR ddPTM_A459_Selumetinib_30min_R2 1 LNASPAAR 8 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 LNAS(1)PAAR 93.442 0.024057 81212000.0 116690.0 128190.0 132860.0 146030.0 144870.0 96892.0 110720.0 118140.0 84538.0 114570.0 True False 110204.83694708112 138021.76080418384 124311.93224703083 126140.46208419913 126670.13544576774 110237.99350199672 115868.69938751786 118483.76784087002 101447.96218907667 111262.06641139089 0.9904978444279412 1.2405104925325503 1.1172894433524911 1.1337238840935728 1.1384844766176245 0.9907958485544601 1.0414034461583157 1.0649071301873625 0.9117928999626286 1.0 16.763602279800168 -6.758663075638157 24.990448712033036 1.0083130254658206 1.1307245847812495 0.44584184507119684 0.06779097768684936 66.97155037931518 602834.9713212539 0.021859386232140558 0.020938709566979973 1.7431586862596855e-07 6.758663075638157 0.12241155931542891 LNCST(ph)SPEIFR ddPTM_A459_Selumetinib_30min_R1 2 LNCSTSPEIFR 11 0 Q9BRS8 Q9BRS8 LARP6 La-related protein 6 1 LNCS(0.122)T(0.53)S(0.349)PEIFR;LNCS(0.051)T(0.474)S(0.474)PEIFR 132.5 0.0046757 81142900.0 8790.4 10438.5 9148.1 10314.1 9432.2 9096.0 10556.8 8688.0 4214.9 7590.799999999999 True False 8995.199216859108 9216.355567273009 7905.838266916354 8512.93605463574 8579.059175390163 9004.502498507209 9760.492076671555 8457.56601739875 7152.377455883962 8565.153120653395 1.0502088042265971 1.0760292825412954 0.9230235765257697 0.9939035455312828 1.001623561720483 1.0512949823155406 1.139558387244217 0.9874389749092499 0.8350554105842234 1.0 13.064263322498823 -8.008606540859091 24.874128442901092 0.915434178259096 1.0314213831290104 0.33614204906148537 0.06487612099987168 416.41612017547465 1203495.3518998185 0.03917576628388845 0.017302779467200238 9.803777791365965e-09 8.008606540859091 0.11598720486991443 LNCST(ph)SPEIFR ddPTM_A459_Selumetinib_30min_R2 2 LNCSTSPEIFR 11 0 Q9BRS8 Q9BRS8 LARP6 La-related protein 6 1 LNCS(0.177)T(0.607)S(0.216)PEIFR;LNCS(0.047)T(0.689)S(0.264)PEIFR 157.5 0.001312 63177000.0 164437.0 145458.0 160371.0 171249.0 187010.0 141013.0 150314.0 153681.0 136877.0 142248.0 True False 155298.24983346608 156614.1608788125 150052.90445874224 147924.59077899763 163516.13190938803 160436.26076143596 157303.89884154036 154128.18626674105 164256.22466292372 138140.93063531024 1.12420156082089 1.1337274199510878 1.0862305890705153 1.070823760189629 1.18369067847869 1.1613955402181633 1.1387204220943032 1.1157314892690051 1.1890481981517658 1.0 17.0757813224579 -2.6876965064713514 21.703089256704583 1.1250281141122496 1.1260745033084372 0.0 0.054118494247173514 0.0 0.0 0.011841388104912472 0.0 0.0020525960722706338 2.6876965064713514 0.0010463891961876026 LNCSTS(ph)PEIFR ddPTM_A459_Selumetinib_30min_R1 2 LNCSTSPEIFR 11 0 Q9BRS8 Q9BRS8 LARP6 La-related protein 6 1 LNCS(0.065)T(0.216)S(0.72)PEIFR;LNCS(0.241)T(0.241)S(0.519)PEIFR 112.5 0.0076375 60754600.0 6797.7 7912.1 6835.0 7525.6 7771.9 6627.5 6704.1 6195.900000000001 3874.6 5641.0 True False 6956.07318397833 6985.747653764504 5906.8445419675445 6211.395233007893 7068.933017240391 6560.833367288533 6198.404339498124 6031.564604880398 6574.9132104125865 6365.077297993069 1.0928497578767196 1.0975118331975535 0.9280082967460573 0.9758554283333476 1.1105808596337472 1.0307547041663085 0.973814464351046 0.9476027269585825 1.0329667500637705 1.0 12.635962319095732 -7.212143607348286 6.677809583157168 0.984266183884643 1.0374285897465283 0.16003377335000513 0.056481364942448244 0.46856291812180173 51.4796808638771 0.023441391148662033 0.01796584227190909 6.135590871756136e-08 7.212143607348286 0.053162405861885254 LNCSTS(ph)PEIFR ddPTM_A459_Selumetinib_30min_R2 2 LNCSTSPEIFR 11 0 Q9BRS8 Q9BRS8 LARP6 La-related protein 6 1 LNCS(0.061)T(0.211)S(0.728)PEIFR;LNCS(0.062)T(0.213)S(0.725)PEIFR 166.24 0.0006064 62730000.0 138055.0 124579.0 148973.0 147146.0 136265.0 108559.0 119371.0 128733.0 102483.0 114622.0 True False 130382.45577795236 134133.80871537913 139388.2393695382 127104.46095899158 119146.17247544367 123512.01684951558 124921.9880291492 129107.59171710475 122982.46361426957 111312.56503627857 1.1713184017946097 1.205019475309573 1.2522237657905855 1.141869841177105 1.0703748713059662 1.1095963587692101 1.122263133442618 1.1598653905336427 1.104839005140054 1.0 16.764256928683317 -6.1082445289041605 0.020229399970701528 2.642711432680754e-12 2.318590549090259 0.6148565032892137 0.04150661740727158 673.653491538952 3.600537033378759 188.84548657684624 223.96581105774965 7.793911518529932e-07 6.1082445289041605 2.318590549087616 LNDGHFMPVLGFGT(ph)YAPAEVPK ddPTM_A459_Selumetinib_30min_R1 1 LNDGHFMPVLGFGTYAPAEVPK 22 0 P52895;B4DK69;S4R3P0;P52895-2;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 1 LNDGHFMPVLGFGT(0.968)Y(0.032)APAEVPK 99.441 0.00020423 9273900.0 2894.3 3987.5 3986.7 3904.5 3307.5 3310.9 3352.6 4172.9 1832.5 2521.0 True False 2961.731558672563 3520.6416462615434 3445.328037375568 3222.6523715423773 3008.3372089865534 3277.595352056673 3099.710682806254 4062.221136510503 3109.618659495448 2844.594906619486 1.041178676014815 1.2376601104321987 1.2111840703075687 1.1329037973186045 1.057562608294781 1.1522186672097239 1.0896843960428613 1.4280490789945353 1.0931674848532003 1.0 11.474007500349408 LNDGHFMPVLGFGTYAPAEVPK ddPTM_A459_Selumetinib_30min_R1 2 LNDGHFMPVLGFGTYAPAEVPK 22 0 P52895;B4DK69;S4R3P0;P52895-2;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 0 ; 167.57 1.4187999999999994e-11 61917000.0 9413.6 10111.2 11108.0 12257.9 10641.7 8770.8 9930.7 10067.900000000001 5484.3 7877.0 False True 9632.918564323 8927.376003430645 9599.594611876442 10117.287874280779 9679.160113944727 8682.573715249226 9181.61930374756 9800.866586851853 9306.456542576196 8888.089678477467 1.083800784284292 1.0044201089744076 1.0800515025317405 1.1382972314939417 1.089003426392382 0.9768773751545399 1.0330250521640074 1.1026966357669272 1.0470705043752884 1.0 13.117657657874467 LNDGHFMPVLGFGTYAPAEVPKS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 LNDGHFMPVLGFGTYAPAEVPKSK 24 1 P52895;B4DK69;S4R3P0;P52895-2;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 1 LNDGHFMPVLGFGT(0.037)Y(0.012)APAEVPKS(0.951)K 74.058 0.00020737 4317100.0 778.81 1426.1 2284.6 2323.6 1317.2 1535.0 1171.1 1060.8 732.55 1166.5 True False 796.9547576995401 1259.1315490240966 1974.363868409518 1917.8268793740206 1198.0594925705489 1519.5592936684877 1082.7629841419803 1032.6641380359804 1243.0838466648781 1316.2316376722054 0.6054821468271179 0.9566185107439812 1.500012468854828 1.4570587915404878 0.91021934003148 1.1544771073546547 0.8226234297611009 0.7845610973629821 0.9444263540597677 1.0 10.362197689475067 -7.260020318195781 24.55841444852049 0.8699494744979115 1.1170688316274384 0.139675752510798 0.2501761829140442 193.44355233517837 3347800.2909713974 0.10741167560823507 0.07862538538160468 5.4951516453285935e-08 7.260020318195781 0.24711935712952693 LNDS(ph)PTLK ddPTM_A459_Selumetinib_30min_R1 2 LNDSPTLK 8 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 LNDS(0.968)PT(0.032)LK;LNDS(0.999)PT(0.001)LK 147.58 0.0016893 73420000.0 10107.9 11119.2 12211.3 12562.5 10160.7 10149.2 10112.9 9953.6 5775.0 8990.9 True False 10343.39440345037 9817.358894824167 10553.072531869535 10368.695202330926 9241.666479017284 10047.10826273629 9350.075811057493 9689.598194150569 9799.753210688239 10144.969593782283 1.0195589358680481 0.9677070792642981 1.0402271228429676 1.0220528614187037 0.910960490673267 0.9903537087872623 0.9216465091022087 0.9551135766921564 0.9659716690224855 1.0 13.308476920645475 -6.237921064739924 24.98997813185653 0.954962579651722 1.011183733850073 0.43561239426553555 0.03061092963946329 728.7689236131462 774371.8044952678 0.008643508552133411 0.011152560639557373 5.782011288906188e-07 6.237921064739924 0.05622115419835105 LNDS(ph)PTLK ddPTM_A459_Selumetinib_30min_R2 5 LNDSPTLK 8 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 LNDS(0.994)PT(0.006)LK;LNDS(0.997)PT(0.003)LK;LNDS(0.996)PT(0.004)LK;LNDS(0.997)PT(0.003)LK;LNDS(0.996)PT(0.004)LK 132.03 0.0034183 184127500.0 989438.0 863233.0 896208.0 1006821.0 877954.0 657852.0 805977.0 855890.0 651726.0 844707.0 True False 934448.9969941372 929440.1953684214 838546.9529974925 869690.2429368997 767657.569511656 748465.1416141225 843456.5275131271 858380.4981997825 782089.4107459161 820318.1140976386 1.1391300288694028 1.1330241029613475 1.0222216705770368 1.060186564200854 0.9358047278476717 0.9124084044364236 1.0282066347406469 1.046399541163385 0.9533977091390031 1.0 19.64582396054837 -5.386726815423102 1.3700134777249207 0.9846567039996957 1.1553232366401345 0.6354070894413157 0.04385732714135819 0.3797039019880021 1.2071988011183128 0.014746332314516039 0.06573142152582928 4.10462215146493e-06 5.386726815423102 0.17066653264043874 LNECIS(ph)PVANEMNHLPAHSHDLQR ddPTM_A459_Selumetinib_30min_R1 2 LNECISPVANEMNHLPAHSHDLQR 24 0 P23497-5;P23497-2;P23497-3;P23497;P23497-4 P23497-5 SP100 Nuclear autoantigen Sp-100 1 LNECIS(1)PVANEMNHLPAHSHDLQR;LNECIS(1)PVANEMNHLPAHSHDLQR 124.82 5.7833e-08 36183800.0 3719.0 4586.4 4117.1 4232.0 4921.5 4173.1 4556.1 4383.799999999999 2417.1000000000004 3619.0 True False 3805.6454640857096 4049.4221558404865 3558.020433611494 3492.9606444787664 4476.351193961399 4131.122402871637 4212.429708862847 4267.527383410752 4101.642162000789 4083.5339020451916 0.9319490312495496 0.9916465132840894 0.8713091452061901 0.8553769181956239 1.0961954281117807 1.0116537543137847 1.0315647696112182 1.0450574149202996 1.0044344580919307 1.0 11.995602489863408 -6.260388802958194 24.999999120460473 1.0327496705572854 0.9152714633289445 0.6515502818917092 0.04257806769802552 63.24084730686541 1504907.2833867697 0.013399708880927555 0.016313732650094687 5.490491165047621e-07 6.260388802958194 -0.1174782072283409 LNECIS(ph)PVANEMNHLPAHSHDLQR ddPTM_A459_Selumetinib_30min_R2 4 LNECISPVANEMNHLPAHSHDLQR 24 0 P23497-5;P23497-2;P23497-3;P23497;P23497-4 P23497-5 SP100 Nuclear autoantigen Sp-100 1 LNECIS(1)PVANEMNHLPAHSHDLQR;LNECIS(0.996)PVANEMNHLPAHS(0.004)HDLQR;LNECIS(1)PVANEMNHLPAHSHDLQR;LNECIS(1)PVANEMNHLPAHSHDLQR 86.89 3.5626e-05 41221800.0 56288.7 40796.4 58533.1 57595.4 64355.5 41744.899999999994 38322.4 48354.6 42195.5 49108.2 True False 53160.39939551942 43925.35269889859 54767.14407202065 49750.8071623932 56270.58674453033 47494.88105252758 40104.46753439499 48495.30388046505 50635.779040776666 47690.318667573185 1.114700024675356 0.9210538726965025 1.148391237512517 1.0432055929251114 1.1799163502505858 0.9959019436123312 0.8409351972240824 1.0168794261682972 1.0617622288023467 1.0 15.541408802428323 -6.978684033293957 24.7862101679053 0.972317628819144 1.0755135420016302 0.25341162807776907 0.084060707568076 305.30487075037667 355007.3046131673 0.029761108424923736 0.02624454539390242 1.0503062908258733e-07 6.978684033293957 0.10319591318248622 LNEQAS(ph)EEILK ddPTM_A459_Selumetinib_30min_R1 2 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 LNEQAS(1)EEILK;LNEQAS(1)EEILK 154.72 0.000538 16803000.0 5477.6 6344.4 3049.3 2895.6 3450.4 3967.7999999999997 5275.200000000001 5246.4 2954.5 5198.6 True False 5605.217422445787 5601.594698568456 2635.221808605945 2389.9378171438357 3138.311929217596 3927.8875344741505 4877.287416912118 5107.248429291067 5013.570711857736 5865.89094865215 0.955561136664796 0.9549435452521627 0.4492449368175622 0.4074296365316832 0.5350102749419011 0.6696148238788331 0.8314657499783232 0.8706688334300858 0.8546989290705689 1.0 12.518134535214651 -7.3533432865472586 2.8039031263892475 0.8932746990325416 0.6465056515924761 0.288335636848322 0.17681969652588958 0.42945544004337677 6.566203547423919 0.09610712473775554 0.06067723513454542 4.432581335856113e-08 7.3533432865472586 -0.24676904744006556 LNEQAS(ph)EEILK ddPTM_A459_Selumetinib_30min_R2 2 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 LNEQAS(1)EEILK;LNEQAS(1)EEILK 127.57 0.0029421 8565800.0 52030.0 37619.0 42894.0 48571.0 54438.0 49161.0 55175.0 59635.0 52296.0 38826.0 True False 49138.380892592526 40504.256335849925 40134.24673945601 41955.546010351536 47599.01175810523 55932.48151087465 57740.74682718839 59808.52797689428 62756.66127232663 37704.99249793714 1.3032327455119082 1.074241198644077 1.0644279200334483 1.1127318487769742 1.2624060795320247 1.483423753868529 1.5313820001515028 1.5862230440747715 1.6644125118380564 1.0 15.2024679421719 -6.621215449664692 2.765076231518225 1.4978715738839246 1.1304760955852378 0.3954813000395664 0.17969958664504002 0.2331523989776446 3.6098211360557766 0.06125270032293363 0.06160410020977517 2.3921287480093596e-07 6.621215449664692 -0.3673954782986868 LNEQAS(ph)EEILKVEQK ddPTM_A459_Selumetinib_30min_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 LNEQAS(1)EEILKVEQK 63.302 0.040021 5481700.0 1312.6 1689.2 1351.6 1328.3 1517.8 1425.4 1572.3 1394.1 934.5 1323.0 True False 1343.1810261250068 1491.427678712226 1168.0601438073645 1096.3373402790983 1380.5152579893545 1411.06177015965 1453.7001451340068 1357.1239393250003 1585.7782468204616 1492.8199371112983 0.8997609106990812 0.9990673634746824 0.7824521328859229 0.7344069522547917 0.9247701103595518 0.945232398818403 0.9737947015545687 0.9091008939437945 1.0622702761386236 1.0 10.543824443769546 -6.509240402220104 14.96284585162333 0.9680100809921066 0.8554840622045038 0.37390444322071126 0.07516704827111073 4.323399104831214 4742.80921728469 0.025610241036345013 0.027674456312586998 3.095705207851275e-07 6.509240402220104 -0.11252601878760282 LNEQASEEILK ddPTM_A459_Selumetinib_30min_R2 1 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 134.2 0.023209 2618100.0 18294.0 13875.0 18263.0 19413.0 18969.0 17862.0 20944.0 19464.0 20387.0 15934.0 False True 17277.29271668437 14939.167884843222 17087.978463250918 16768.915910707106 16585.94463498838 20322.328364908004 21917.93749974868 19520.637017561337 24464.96966037407 15473.94401849612 1.1165409863207914 0.96544021789056 1.1043065971303456 1.0836872545656813 1.0718627788211639 1.3133257003267282 1.4164415661288425 1.261516585185275 1.5810429216449866 1.0 13.917553339149887 -6.7763804028641585 5.005604629820081 1.3399104186140582 1.0639841051491559 0.426194968689245 0.1415165058801527 0.15753735749470113 10.53672606332854 0.04627616353879221 0.0426615158123236 1.673476419207447e-07 6.7763804028641585 -0.2759263134649024 LNFDMT(ph)ASPK ddPTM_A459_Selumetinib_30min_R2 1 LNFDMTASPK 10 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 LNFDMT(0.897)AS(0.103)PK 132.06 0.005857 20491000.0 97094.0 74679.0 69556.0 72885.0 62389.0 53218.0 76979.0 65263.0 49010.0 54453.0 True False 91697.90417807768 80406.63916916825 65080.842686846685 62957.937266362045 54551.13605526333 60548.29643509543 80558.67603099474 65452.90452512871 58813.36945381531 52880.80040411505 1.7340490967860234 1.5205261371745653 1.2307083514148598 1.1905632438472473 1.0315868072794583 1.1449958391776482 1.5234012234188095 1.2377442100901963 1.1121875804519517 1.0 15.690456393201188 -5.067762424317825 2.0920915571830996 1.1930483618951608 1.7559759066669818 0.6467811229609238 0.13571082112587315 0.27861376288900724 2.0095889595272616 0.0395009764221864 0.2373057192249801 8.5553459502394e-06 5.067762424317825 0.5629275447718209 LNFDMTAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 LNFDMTASPK 10 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 LNFDMT(0.003)AS(0.997)PK 110.92 0.0091632 46427000.0 3227.2 3806.6 3566.3 3571.8 2660.4 3120.0 2937.8 2870.8 1980.6 3090.9 True False 3302.387480961924 3360.9215023596716 3082.016048283665 2948.0521809898983 2419.7672897317693 3088.615632733342 2716.19938076365 2794.657058327385 3360.933542699419 3487.647122915579 0.9468811965704882 0.9636644373442321 0.8836949208632043 0.8452839628240273 0.693810814125286 0.8855871950002048 0.7788056775918833 0.8013015536936338 0.9636678896257627 1.0 11.76803836153905 -5.467730908021634 2.832639136306947 0.8364642192114502 0.955594259486703 0.1706333173317952 0.08400358332959589 0.38074021492942606 5.972799757878072 0.0227009284574681 0.052893156758079374 3.4061917441587143e-06 5.467730908021634 0.11913004027525276 LNFDMTAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 LNFDMTASPK 10 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 LNFDMT(0.004)AS(0.996)PK 141.34 0.0013192 20945000.0 229000.0 190100.0 211550.0 180430.0 200880.0 156960.0 177010.0 175190.0 132520.0 161810.0 True False 216273.09675963272 204680.0587321582 197939.10331822408 155855.12274088897 175643.65851001468 178579.81525898352 185241.31573866087 175699.7738957342 159027.70291817212 157138.12486713077 1.3763247903238247 1.3025486902381382 1.2596504093808734 0.9918351951359566 1.1177660332814292 1.136451229833517 1.1788438731548625 1.1181231419446958 1.0120249497226665 1.0 17.261673724348626 -5.591279633671978 5.236285904930007 1.0927679286958023 1.3268825480758413 0.7483949118020466 0.06267764044970824 0.10222490060200919 5.2516402363348895 0.017760547573931366 0.0316695220828805 2.5628333471840838e-06 5.591279633671978 0.23411461938003897 LNFDVS(ph)S(ph)PNGILLFREASK ddPTM_A459_Selumetinib_30min_R1 1 LNFDVSSPNGILLFREASK 19 1 Q9H2T7 Q9H2T7 RANBP17 Ran-binding protein 17 2 LNFDVS(1)S(1)PNGILLFREASK 69.069 0.035847000000000004 23099000.0 3570.8 4712.8 4173.1 4855.3 3944.7 3923.8 3963.0 4047.2 2054.5 3381.8 True False 3653.99269243271 4161.023185078719 3606.415941197476 4007.4130002688453 3587.9025814933493 3884.3301345253503 3664.0677193703973 3939.8551088416452 3486.336445256968 3815.886971521533 0.9575736177992008 1.0904471794193547 0.9451055463939664 1.050191745766239 0.9402538933334081 1.0179363706301099 0.9602139022239959 1.0324873714146416 0.9136372411646247 1.0 11.897802723290527 -6.259693046753863 24.99905118749621 0.9802112001808824 1.0118219257405734 0.09172042485802478 0.0510140007417765 394.22350085783705 5643345.673552162 0.014124457056388328 0.017371442166921266 5.499294189294772e-07 6.259693046753863 0.03161072555969102 LNFSHGTHEYHAETIK ddPTM_A459_Selumetinib_30min_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 91.789 0.003972099999999999 24392000.0 3677.8 3728.6 3798.3 4221.3 6350.7 4141.0 4904.3 3877.9 1174.1 2607.8 False True 3763.485584246955 3292.0537786208856 3282.511722568443 3484.129198614891 5776.28030630715 4099.3452997271725 4534.36470252542 3775.045494805549 1992.3619471288416 2942.5365321230856 1.2789936652142573 1.1187809370188577 1.1155381374993703 1.184056395079329 1.9630275591309223 1.393133187974197 1.5409714214334005 1.282922218159105 0.6770899614596532 1.0 11.52284461135678 -8.15807537666107 5.456428660177814 0.8445174477677296 1.3697769558355142 0.41964474396641915 0.24633234690682637 0.22407437700316407 9.411784757978259 0.18832874809065617 0.06820729814644474 6.9490369881846035e-09 8.15807537666107 0.5252595080677845 LNGDTEEGFNRLS(ph)DEFSK ddPTM_A459_Selumetinib_30min_R1 2 LNGDTEEGFNRLSDEFSK 18 1 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 1 LNGDTEEGFNRLS(0.996)DEFS(0.004)K;LNGDTEEGFNRLS(0.99)DEFS(0.009)K 66.732 0.016973 18653200.0 2315.42 2596.74 3052.62 3242.0 2563.6 2370.69 2734.0 2612.24 1589.3899999999999 2499.71 True False 2369.364780976964 2292.7124736083247 2638.0909708414 2675.8455598771625 2331.72283264034 2346.8430110142963 2527.7721788439735 2542.954909448631 2697.0787455473237 2820.572127737326 0.8400298498580421 0.8128536941360006 0.9353034956626645 0.9486889321365224 0.8266843487923343 0.832045026587192 0.8961912918255214 0.9015741467631248 0.9562169033099434 1.0 11.461772114708372 -8.29738125045056 1.4260939413470763 0.9991821580604497 0.8695060399285907 0.5126725480734853 0.042876551278858845 0.36017833240562924 1.4486527372396978 0.04419267264460846 0.013587335805731978 5.04218469186747e-09 8.29738125045056 -0.12967611813185909 LNGPGENVS(ph)EDEAQSSNQR ddPTM_A459_Selumetinib_30min_R1 4 LNGPGENVSEDEAQSSNQR 19 0 A0A3B3ISF0;Q659C4-2;Q659C4;H0Y9K3;D6R9W6;D6RJB0;Q659C4-9;A0A3B3IT29;A0A3B3ISF8;G3V0E9;Q659C4-3 A0A3B3ISF0 LARP1B La-related protein 1B 1 LNGPGENVS(0.998)EDEAQS(0.002)SNQR;LNGPGENVS(1)EDEAQSSNQR;LNGPGENVS(0.999)EDEAQS(0.001)SNQR;LNGPGENVS(1)EDEAQSSNQR 306.82 1.1237999999999993e-101 39964200.0 7138.96 8171.2300000000005 9060.14 9120.880000000001 8200.17 7932.0599999999995 8446.34 8372.05 5076.73 7279.97 True False 7305.283878001961 7214.538592898231 7829.822751786655 7528.089528122276 7458.466071357596 7852.270678134241 7809.225773612653 8149.996037748987 8614.840020311229 8214.425062412798 0.88932382029135 0.8782767555954947 0.9531796434073044 0.9164475262631555 0.9079717709624882 0.9559123880823155 0.9506722277309172 0.9921565996190503 1.048745341865815 1.0 13.003943887392806 -7.4867781814688374 0.9779074893207087 1.0252800375058553 0.9080761806913838 0.7736805114575773 0.02415753244581622 0.26749285455583033 0.4752356357265094 0.020167609828442852 0.009730876218181259 3.2600316657417305e-08 7.4867781814688374 -0.11720385681447143 LNGPGENVS(ph)EDEAQSSNQR ddPTM_A459_Selumetinib_30min_R2 4 LNGPGENVSEDEAQSSNQR 19 0 A0A3B3ISF0;Q659C4-2;Q659C4;H0Y9K3;D6R9W6;D6RJB0;Q659C4-9;A0A3B3IT29;A0A3B3ISF8;G3V0E9;Q659C4-3 A0A3B3ISF0 LARP1B La-related protein 1B 1 LNGPGENVS(1)EDEAQSSNQR;LNGPGENVS(1)EDEAQSSNQR;LNGPGENVS(0.999)EDEAQS(0.001)SNQR;LNGPGENVS(1)EDEAQSSNQR 332.57 9.132299999999992e-155 74722400.0 148535.0 138790.0 162041.0 166039.0 156816.0 124128.0 117441.0 122945.0 115780.0 128507.0 True False 140280.0193327165 149434.74671981196 151615.45847690085 143424.201766749 137115.37212717286 141225.50527820524 122902.2392049266 123302.74959535968 138939.23516349227 124796.669008716 1.124068618553586 1.1974257638989965 1.2148998821940655 1.1492630605127132 1.0987101916766424 1.1316448299460768 0.9848198688407535 0.9880291723711634 1.1133248689016575 1.0 16.929219901675914 -6.788338491773901 1.2999373088005146 1.0224348935807723 1.1767374836218838 0.6483231355254745 0.0469515735565046 0.2687057054337598 0.9517846048417178 0.023280845886924802 0.02049354999584105 1.6280266441013614e-07 6.788338491773901 0.15430259004111146 LNHS(ph)PPQSSSR ddPTM_A459_Selumetinib_30min_R1 1 LNHSPPQSSSR 11 0 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6 A0A087X0H9 RBM26 RNA-binding protein 26 1 LNHS(1)PPQSSSR 77.633 0.032485 44233000.0 685.9 764.18 496.74 471.34 656.47 602.49 603.86 506.95 360.91 359.95 True False 701.8801354709295 674.7094503423558 429.28543639750666 389.02931714759467 597.0924044091923 596.4294976171511 558.310354029525 493.504039194325 612.4379101765355 406.1530887099104 1.7281171927076946 1.6612195477460923 1.056954750143777 0.9578391201782879 1.4701166161404178 1.4684844562222281 1.3746303291769153 1.2150690291728987 1.5078991818623382 1.0 8.665879805593137 -1.5228787544172588 0.028903661254499842 2.6821961904958398e-08 3.259664388546707 0.19558520656413036 0.23282100044603474 3201.863766224947 7.127465802884471 260.7785742299282 611.1925110333559 0.029999999368843844 1.5228787544172588 3.259664361724745 LNHS(ph)PPQSSSR ddPTM_A459_Selumetinib_30min_R2 2 LNHSPPQSSSR 11 0 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6 A0A087X0H9 RBM26 RNA-binding protein 26 1 LNHS(1)PPQSSSR;LNHS(1)PPQSSSR 82.48299999999998 0.026395 72331600.0 12052.9 10943.400000000001 12729.0 13781.1 14955.5 13365.8 12365.2 15200.6 14004.2 14832.7 True False 11383.048069581559 11782.723591422953 11910.0299982873 11904.090406276495 13076.656386133633 15206.81762734786 12940.20630117897 15244.831229405205 16805.43131004123 14404.441411017151 0.7902457127476878 0.8179923993728079 0.8268303961567011 0.8264180516692388 0.907821137453621 1.055703389908408 0.8983483588111741 1.058342409428337 1.1666839990884823 1.0 13.814226094946177 -6.672621950313886 0.7779839324159101 1.0692757381430809 0.7919005999336921 0.7323860333109475 0.06291318787536582 0.3460187890625569 0.46333700747154316 0.04245111480411604 0.045314147505806215 2.1250935330925985e-07 6.672621950313886 -0.27737513820938875 LNHVAAGLVS(ph)PSLK ddPTM_A459_Selumetinib_30min_R1 3 LNHVAAGLVSPSLK 14 0 Q5T757;Q05519-2;Q05519;Q5T760 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 LNHVAAGLVS(0.753)PS(0.247)LK;LNHVAAGLVS(0.995)PS(0.005)LK;LNHVAAGLVS(0.982)PS(0.018)LK 129.11 0.00071416 466506000.0 15742.2 19064.5 16862.600000000002 18720.6 16943.1 15091.0 17670.1 16450.5 8501.19 13302.800000000001 True False 16108.962631011038 16832.419477154406 14572.751539631581 15451.398639184577 15410.599596547256 14939.198241531698 16337.230130720867 16014.179301245189 14425.898527648627 15010.343960245033 1.0731907725549596 1.1213879922895271 0.9708472756005847 1.0293833825598988 1.026665320752296 0.9952602206250727 1.0883981189231973 1.0668762383899275 0.9610638214457768 1.0 13.873669416071955 -5.248212494923308 24.995576612634814 1.022216656769421 1.097289386612311 0.3977325249793344 0.038994637987749284 825.7223601052445 1560406.3055801117 0.009967746534039586 0.02602680409247322 5.646606257442016e-06 5.248212494923308 0.07507272984288993 LNHVAAGLVS(ph)PSLK ddPTM_A459_Selumetinib_30min_R2 2 LNHVAAGLVSPSLK 14 0 Q5T757;Q05519-2;Q05519;Q5T760 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 LNHVAAGLVS(1)PSLK;LNHVAAGLVS(0.977)PS(0.023)LK 101.28 0.005557899999999999 167032000.0 409248.0 393081.0 410224.0 430541.0 480862.0 357423.0 342929.0 371167.0 300023.0 364762.0 True False 386503.6345095466 423229.04874537355 383830.6344581197 371900.5730753489 420451.8165991768 406654.7738870517 358875.87800092227 372247.0345199952 360035.9833430337 354230.3732945069 1.0911081139510521 1.1947847521067911 1.0835621770327502 1.0498833558977478 1.1869445657321243 1.147995215952188 1.0131143601922388 1.0508614240442595 1.016389362647059 1.0 18.434328394947507 -7.265034709360528 24.98768401039589 1.0243297338525248 1.1262731553564644 0.5813545016458342 0.04384930857634889 246.05651977887518 1710090.6464701267 0.01843153017949592 0.012975340071515967 5.432069159784771e-08 7.265034709360528 0.10194342150393965 LNHVAAGLVS(ph)PSLKSDTSSK ddPTM_A459_Selumetinib_30min_R1 1 LNHVAAGLVSPSLKSDTSSK 20 1 Q5T757;Q05519-2;Q05519;Q5T760 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 LNHVAAGLVS(0.995)PS(0.004)LKSDTSSK 99.454 0.00044959 21214000.0 1207.3 451.22 4621.7 4580.0 2053.9 1649.0 1268.3 1262.4 902.28 594.98 True False 1235.4277410031402 398.39095263351317 3994.0985251808897 3780.1889772478157 1868.1251076454969 1632.4125571722063 1172.6311098858112 1228.9170511468903 1531.1032600761537 671.351478595979 1.8402100544811995 0.5934163628665602 5.949340475921628 5.630715203239678 2.7826334896176483 2.4315319310625907 1.7466724171639214 1.83051216885225 2.280628417290752 1.0 9.390924460920179 -6.783122809382613 2.756159960076958 1.8298329288479747 3.5166534759478627 0.20899371837507563 1.5158804189003026 0.4972604806949534 7.742862006293313 0.6329621087011665 0.5798546245724144 1.6476963916147262e-07 6.783122809382613 1.686820547099888 LNINSS(ph)PDEHEPLLR ddPTM_A459_Selumetinib_30min_R2 1 LNINSSPDEHEPLLR 15 0 Q13873 Q13873 BMPR2 Bone morphogenetic protein receptor type-2 1 LNINS(0.199)S(0.801)PDEHEPLLR 155.92 0.00011102 2683300.0 7002.3 8176.0 10111.0 12527.0 12258.0 8048.7 10657.0 11206.0 10897.0 8704.3 True False 6613.140198427844 8803.07291001645 9460.469268024428 10820.800989719657 10718.040452089606 9157.335366175967 11152.571616444888 11238.607604746829 13076.704487619381 8452.984242512593 0.7823438455224343 1.0414159848711364 1.1191869044833764 1.280116072534313 1.267959355488369 1.083325734847698 1.3193650072545102 1.329543186443493 1.546992649276774 1.0 13.045245045205231 -4.224732110757118 0.7204019666355921 1.2847665276736975 3.1177940963958458e-15 0.5299424730239991 0.1399917383355968 4.5538494006254 1.0146312056554827 0.055725238651775436 5.713462861756983 5.960296837863115e-05 4.224732110757118 -1.2847665276736944 LNLESS(ph)NSK ddPTM_A459_Selumetinib_30min_R2 1 LNLESSNSK 9 0 G5EA36;P30260;P30260-2;I3L225;F6QPS0 G5EA36 CDC27 Cell division cycle protein 27 homolog 1 LNLES(0.233)S(0.766)NS(0.002)K 80.737 0.04565 3871200.0 40229.0 33872.0 38997.0 44261.0 43975.0 33833.0 44569.0 41667.0 30377.0 42512.0 True False 37993.233229446574 36469.87348435384 36487.975476723244 38232.57544551627 38450.467358512025 38493.188644604896 46641.54681179808 41788.244071656794 36453.24880429603 41284.56810055898 0.9202768728718312 0.883377861566149 0.8838163303016172 0.9260742501263713 0.9313520554425133 0.9323868558063881 1.1297574119751193 1.0122001027083773 0.8829751764752619 1.0 15.33331499205964 -7.021793985718201 24.57538709870965 1.0106530410534915 0.9095849548285591 0.39352056223886067 0.0572837004275406 648.5421219278898 731308.7467182564 0.02235843764680582 0.017492262816939205 9.510558346636475e-08 7.021793985718201 -0.10106808622493246 LNLGTDSDS(ph)SPQK ddPTM_A459_Selumetinib_30min_R2 1 LNLGTDSDSSPQK 13 0 Q16512;Q16512-2;K7EN76;Q16512-3 Q16512 PKN1 Serine/threonine-protein kinase N1 1 LNLGTDS(0.001)DS(0.511)S(0.488)PQK 115.57 0.0039777 52859000.0 127330.0 101110.0 129270.0 136750.0 136630.0 101680.0 116870.0 116770.0 96931.0 122970.0 True False 120253.50834237573 108864.81188010795 120952.90893853422 118124.4140930921 119465.31791230243 115685.4970408602 122304.68657351166 117109.78136768572 116319.90847842823 119419.5365855698 1.0069835454118377 0.9116164322250666 1.0128402135597443 0.9891548524679654 1.0003833654696845 0.9687317531831654 1.0241597821464874 0.9806584811503682 0.9740442125654998 1.0 16.86567934981243 -5.3024752150010555 24.99993750491984 0.9933216490580757 0.9592997799986064 0.21020190817847495 0.02669809151631348 627.7084180249811 382412.69983359263 0.006467616848899179 0.013463599083381673 4.983388951450276e-06 5.3024752150010555 -0.034021869059469356 LNLGTDSDSS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 4 LNLGTDSDSSPQK 13 0 Q16512;Q16512-2;K7EN76;Q16512-3 Q16512 PKN1 Serine/threonine-protein kinase N1 1 LNLGTDS(0.012)DS(0.1)S(0.888)PQK;LNLGTDSDS(0.03)S(0.97)PQK;LNLGTDSDS(0.029)S(0.971)PQK;LNLGTDS(0.001)DS(0.085)S(0.914)PQK 206.67 1.2013e-05 137411000.0 17115.1 20070.0 22487.9 23029.3 21067.0 18173.5 19187.199999999997 17835.0 9305.8 14740.900000000001 True False 17513.84852981266 17720.195069710124 19434.166697192664 19007.66506850066 19161.493569680948 17990.691090217744 17739.894056296664 17361.957863755375 15791.262931259344 16633.038103525265 1.0529554745684564 1.065361298364034 1.1684075137826877 1.1427656781759015 1.1520140488116717 1.0816238728151975 1.0665456271958402 1.0438236091141775 0.9493913759454737 1.0 14.021764087355157 -7.763252911693147 1.4223349412898065 0.9770932762637848 1.1152525555339645 0.6542270804671089 0.03821866835758541 0.2825427858227389 1.0587062427221707 0.033622720568662834 0.013034955717729653 1.7248331416821502e-08 7.763252911693147 0.13815927927017968 LNLGTDSDSS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 3 LNLGTDSDSSPQK 13 0 Q16512;Q16512-2;K7EN76;Q16512-3 Q16512 PKN1 Serine/threonine-protein kinase N1 1 LNLGTDSDS(0.023)S(0.977)PQK;LNLGTDSDS(0.006)S(0.994)PQK;LNLGT(0.002)DS(0.017)DS(0.396)S(0.585)PQK 255.28 1.2365999999999997e-23 117855000.0 267455.0 237877.0 258627.0 280314.0 277635.0 198793.0 245801.0 226264.0 180825.0 239960.0 True False 252590.92180719465 256121.40100489015 241987.22039178672 242134.74963137877 242756.00921160876 226174.93128681878 257231.23354544144 226922.39077997807 216995.05267264112 233031.73130904546 1.083933593027337 1.099083801017739 1.0384303417926573 1.0390634282773317 1.0417294153372916 0.9705756809010133 1.1038463822092226 0.9737832247361832 0.9311824250443534 1.0 17.8301668906266 -5.41423006099601 0.32814693535087025 0.9753685853909294 1.1513439627010627 0.4259006684885005 0.042014920033875046 4.722891735991111 0.5639057493434934 0.04678116707196003 0.3202551956039669 3.852742103570692e-06 5.41423006099601 0.17597537731013324 LNLTLS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 LNLTLSPAK 9 0 A0A087WTW5;Q9UKL3 A0A087WTW5 CASP8AP2 CASP8-associated protein 2 1 LNLT(0.009)LS(0.991)PAK;LNLT(0.028)LS(0.972)PAK 101.71 0.016779 15140700.0 125190.0 99903.0 101313.0 118236.0 101344.0 80949.0 101767.0 96530.0 77028.0 100572.0 True False 118232.44097527706 107565.23886122489 94794.63188125407 102132.05283152337 88612.26069314488 92098.98996814131 106499.3671474849 96810.88631859822 92435.75234214438 97668.22504256252 1.2105517523611484 1.101332995601685 0.9705780138826504 1.045703992132708 0.907278295008728 0.9429780251254263 1.0904198074765246 0.9912219278727479 0.9464260490232325 1.0 16.57560165791854 -4.9436896719897065 2.094885437327551 0.9868869040025642 1.2364806509691435 0.670746278739127 0.05010971056862433 0.2947013698252272 1.8994684695843413 0.013993167450735347 0.12446052404215277 1.1384404754666715e-05 4.9436896719897065 0.24959374696657932 LNLTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 LNLTSPK 7 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 LNLT(0.079)S(0.921)PK;LNLT(0.079)S(0.921)PK 84.81700000000002 0.037033 186090000.0 869740.0 836330.0 797280.0 748060.0 682870.0 481100.0 663350.0 654780.0 473200.0 601690.0 True False 821403.3326450777 900473.8217752017 745983.8728128311 646172.9375245213 597081.7656647433 547367.1580090271 694197.089403089 656685.3013953362 567853.2223126997 584317.6463216343 1.4057479485959954 1.5410690186131073 1.2766752424967986 1.1058590162256354 1.0218444871953825 0.9367630114455452 1.1880474494877264 1.1238498538068582 0.9718228191248705 1.0 19.1563933335919 -5.596814387264084 2.3822771380991843 1.0503642694110245 1.4739804285912474 0.8326654668867729 0.0769755994366389 0.11289772282567874 1.2848496600034873 0.022880556696400843 0.04965959207181928 2.5303792219235466e-06 5.596814387264084 0.423616159180223 LNNDDNVDGLLVQLPLPEHIDER ddPTM_A459_Selumetinib_30min_R1 2 LNNDDNVDGLLVQLPLPEHIDER 23 0 P13995-2;P13995 P13995-2 MTHFD2 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial;NAD-dependent methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase 0 ; 126.32 1.3616e-05 4127900.0 567.9499999999999 730.8499999999999 772.3 816.3499999999999 766.75 687.21 649.78 556.71 446.68 637.24 False True 581.1821299616771 645.2817422370528 667.4259019402391 673.7897972873911 697.3975978807073 680.2972913367563 600.7665714591211 541.9442423510653 757.9833357835884 719.0359612432376 0.8082796428662531 0.8974262443304487 0.9282232571320036 0.9370738511080666 0.9699064239775758 0.9461241551263989 0.8355167249498555 0.7537095104590115 1.0541661010570451 1.0 9.489920115946799 -4.769476920214962 3.165875647280075 0.9183143347237163 0.7902112930526339 0.16288881230679186 0.07935718820781199 0.7462951444575048 11.064091432258115 0.020435620340134724 0.24431333436223845 1.7002903100566824e-05 4.769476920214962 -0.12810304167108233 LNNS(ph)SPNSSGGVK ddPTM_A459_Selumetinib_30min_R2 2 LNNSSPNSSGGVK 13 0 O00472;H0Y8G1;O00472-2 O00472 ELL2 RNA polymerase II elongation factor ELL2 1 LNNS(0.715)S(0.281)PNS(0.003)SGGVK;LNNS(0.99)S(0.01)PNSSGGVK 201.72 1.7132e-22 4342900.0 58169.0 49346.0 54249.0 59979.0 64331.0 51137.0 56583.0 60859.0 45127.0 56050.0 True False 54936.19984895668 53130.67952760173 50758.67840184526 51809.75673045387 56249.16465356306 58180.657574532575 59214.22161708747 61036.0896142502 54153.66095373033 54431.69086461071 1.009268662728131 0.9760982744363936 0.9325206987983999 0.9518307424864231 1.0333899932205486 1.0688747060833874 1.0878629834294964 1.1213337055074548 0.9948921316522771 1.0 15.732159232149284 -6.421290759105794 3.643843577113093 1.0635310948339807 0.9658332733382423 0.5083324163517751 0.04013189943591686 0.18343655128175482 4.4629066694857435 0.01311677694258384 0.01479360261469739 3.79061119498821e-07 6.421290759105794 -0.09769782149573836 LNNSSPNSS(ph)GGVK ddPTM_A459_Selumetinib_30min_R2 1 LNNSSPNSSGGVK 13 0 O00472;H0Y8G1;O00472-2 O00472 ELL2 RNA polymerase II elongation factor ELL2 1 LNNS(0.125)S(0.064)PNS(0.173)S(0.639)GGVK 93.839 0.01658 5641600.0 7101.3 7929.3 10447.0 7861.3 9270.4 7659.3 7039.7 8607.4 7377.4 11811.0 True False 6706.638174756248 8537.451813281978 9774.85139383357 6790.57737850109 8105.769473572484 8714.299050797212 7367.059998900912 8632.44610896822 8853.086141778767 11469.985741336608 0.5847119888376354 0.744329766907548 0.8522112942656977 0.5920301499616143 0.7066939450813922 0.7597480282291725 0.6422902490934066 0.7526117559028696 0.7718480512031665 1.0 13.48557597744933 -8.874399152634227 1.2659618196721631 0.9998183955234946 0.7041879675602426 0.57568811247827 0.07664182982210137 0.9216740350914532 2.355384513775078 0.07281683148617132 0.021923167543785024 1.3353676388029042e-09 8.874399152634227 -0.295630427963252 LNQPGT(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 LNQPGTPTR 9 0 P36507;G5E9C7;M0R1B6 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 LNQPGT(0.974)PT(0.026)R;LNQPGT(0.952)PT(0.048)R 150.09 0.0031737 1083960000.0 7157.6 6867.0 7378.5 7367.799999999999 7485.1 5561.1 6588.7 6527.700000000001 4016.6000000000004 5152.1 True False 7324.358153734843 6063.00844761831 6376.540227199344 6081.152040735033 6808.074026601742 5505.160383074803 6091.709054407194 6354.564191042105 6815.876839142925 5813.422220703795 1.2599047300658868 1.0429327541401765 1.0968651484645435 1.0460537373455778 1.171095745008098 0.946974118526751 1.0478697096371763 1.0930849248160748 1.1724379514133707 1.0 12.505171977954861 -4.756359665301431 24.995901735518622 1.0704339217349255 1.2599050233581013 0.4289522135483368 0.06619095293893405 154.89841528834214 762127.9388914591 0.01612656700146106 0.1313888754947032 1.752428609515336e-05 4.756359665301431 0.18947110162317582 LNQPGT(ph)PTR ddPTM_A459_Selumetinib_30min_R2 5 LNQPGTPTR 9 0 P36507;G5E9C7;M0R1B6 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 LNQPGT(0.999)PT(0.001)R;LNQPGT(0.742)PT(0.258)R;LNQPGT(0.892)PT(0.108)R;LNQPGT(0.909)PT(0.091)R;LNQPGT(0.999)PT(0.001)R 135.1 0.0064453 1423630000.0 532524.0 493504.0 593510.0 613151.0 603159.0 452273.0 453296.0 511243.0 412273.0 530355.0 True False 502928.44794247486 531354.1699345347 555324.2127648281 529638.776055528 527384.7741101251 514569.5004244788 474375.1621889833 512730.6324891647 494739.11987008335 515042.27312222216 0.9764799399740288 1.031670986370553 1.0782109386835648 1.0283403978567056 1.0239640542767139 0.9990820701087749 0.92104121728356 0.995511745824194 0.9605796372226697 1.0 18.974331323666455 -6.923300892026319 3.6052173820482283 0.9678735002017608 1.0307889416508524 0.44184713317486346 0.030656399196009307 0.2102121026109338 5.440168709690464 0.011604728715183858 0.009982263049705377 1.1931611607880978e-07 6.923300892026319 0.06291544144909167 LNQS(ph)AENGSSLPSAASSCAEAR ddPTM_A459_Selumetinib_30min_R2 3 LNQSAENGSSLPSAASSCAEAR 22 0 Q8NB90-3;Q8NB90-2;Q8NB90 Q8NB90-3 SPATA5 Spermatogenesis-associated protein 5 1 LNQS(0.999)AENGS(0.001)SLPSAASSCAEAR;LNQS(0.995)AENGS(0.005)SLPSAASSCAEAR;LNQS(0.998)AENGS(0.001)SLPSAASSCAEAR 263.75 2.9602999999999987e-117 4481600.0 26399.1 25658.6 30119.7 36711.1 37559.0 29759.1 30505.8 28211.2 27330.899999999998 35252.0 True False 24931.943705970385 27626.532114597365 28181.83129384982 31710.98484982017 32840.50263827976 33858.145898787014 31924.38014609593 28293.289921384407 32797.8436891508 34234.18316430431 0.7282762841546839 0.8069867471937614 0.8232073526800188 0.9262959392845962 0.9592897975881098 0.989015737173791 0.9325293375009808 0.8264631227096306 0.9580437053730796 1.0 15.063149969345753 -5.5110046113808675 1.6381303165204528 0.9388008961866979 0.7522539856948166 0.7030939694030518 0.04742558773598991 0.25140947674563974 1.2825287670367564 0.015296417686336286 0.04679531816828085 3.0831552128349163e-06 5.5110046113808675 -0.18654691049188132 LNQS(ph)PSLAPVKR ddPTM_A459_Selumetinib_30min_R2 1 LNQSPSLAPVKR 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 LNQS(0.976)PS(0.024)LAPVKR 64.407 0.041798 30690000.0 153690.0 164330.0 179730.0 190190.0 182560.0 137700.0 156830.0 134280.0 139690.0 181040.0 True False 145148.52506981624 176933.58259576865 168166.36747522827 164285.7939039497 159625.18069289246 156666.92508385598 164122.90575274947 134670.73256874917 167631.9032647103 175812.90480159025 0.8255851595969044 1.0063742635698052 0.9565075309176462 0.9344353538174617 0.9079264168522436 0.8911002594528482 0.9335088680661225 0.7659888943916195 0.9534675708469044 1.0 17.42368144372339 -6.3533056057322215 3.012348620415704 0.8959116656159425 0.9383891351621596 0.002059617655002288 0.07081826911671603 0.7906639464399104 13.890396475642984 0.022480535678097494 0.026381483000313767 4.432965937849384e-07 6.3533056057322215 0.04247746954621712 LNQS(ph)SPDNVTDTK ddPTM_A459_Selumetinib_30min_R1 1 LNQSSPDNVTDTK 13 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 LNQS(0.5)S(0.5)PDNVTDTK 189.33 3.7327e-15 0.0 3054.1 3662.2 3632.2 3659.4 3681.2 3490.6 3354.4 2977.5 2028.8 2972.5 True False 3125.254587755891 3233.4279214894104 3138.9671902464534 3020.354485445556 3348.236109968646 3455.4877332112205 3101.374907357067 2898.527027716941 3442.725422310701 3354.049329601914 0.9317855167403938 0.9640370798819409 0.9358738890757494 0.9005098579763692 0.9982668055648549 1.0302435634187128 0.9246658598563795 0.8641873576918924 1.026438517742168 1.0 11.711688192123887 -6.266037102219736 24.981799579131216 0.9675251530873031 0.9354664291984202 0.13513184003004475 0.04896082897183922 1076.6433069995383 5849956.905744648 0.015926406391626274 0.018647427466744738 5.419545886915858e-07 6.266037102219736 -0.03205872388888298 LNQS(ph)SPDNVTDTK ddPTM_A459_Selumetinib_30min_R2 1 LNQSSPDNVTDTK 13 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 LNQS(0.969)S(0.031)PDNVTDTK 225.6 9.4066e-10 17010000.0 131610.0 138150.0 130190.0 129990.0 140450.0 94046.0 121910.0 118310.0 86629.0 113110.0 True False 124295.64307657313 148745.6607777367 121813.71714015404 112285.13775474246 122805.4153610692 106999.98283541249 127579.05656008213 118654.2625127252 103957.22061649796 109844.22040492628 1.1315628862253615 1.3541509988364009 1.1089679246764534 1.0222216275086486 1.117996148621777 0.9741066251913039 1.161454431464657 1.0802048762813543 0.9464059213427282 1.0 16.745099436938013 -5.466904019808684 6.557922112300476 1.0525620674695013 1.2421023657806098 0.49574938183167305 0.0792626143613434 0.17941312652569097 16.746753259929687 0.01974969600392329 0.04099167035514982 3.412683244609903e-06 5.466904019808684 0.18954029831110852 LNQSPS(ph)LAPVK ddPTM_A459_Selumetinib_30min_R2 2 LNQSPSLAPVK 11 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 LNQS(0.047)PS(0.953)LAPVK;LNQS(0.133)PS(0.867)LAPVK 116.03 0.0060073 13885200.0 90371.0 86516.0 86570.0 88233.0 95287.0 76216.0 91763.0 92368.0 85788.0 85092.0 True False 85348.54160377638 93151.49900721414 81000.18045028912 76215.51318958534 83316.1951834119 86714.06218003746 96030.16132493503 92636.7755876545 102947.99711699453 82635.17286443258 1.0328355184032256 1.1272621061740158 0.9802143281429839 0.9223132299199152 1.008241312934585 1.0493602079382895 1.1620979057244505 1.1210332401631213 1.2458132965472974 1.0 16.33446836114903 -7.1198759115278865 3.714960675146872 1.1421578177034157 1.0143184599794164 0.35904828020934 0.07398962905712776 0.2630393598456718 6.48080573126077 0.030246127748875664 0.023099637165808953 7.587943500175521e-08 7.1198759115278865 -0.12783935772399935 LNQSS(ph)PDNVTDTK ddPTM_A459_Selumetinib_30min_R1 2 LNQSSPDNVTDTK 13 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 LNQS(0.215)S(0.785)PDNVTDTK;LNQS(0.026)S(0.966)PDNVT(0.008)DTK 220.52 1.1806000000000002e-08 79637000.0 6313.1 6276.200000000001 7149.799999999999 7001.599999999999 6225.6 6265.0 5873.8 5351.1 3369.0 5224.0 True False 6460.182946845785 5541.379586273776 6178.896431040165 5778.901996309669 5662.495579218954 6201.979788164872 5430.73453697649 5209.171445177539 5716.946937975532 5894.551286069102 1.0959583916274458 0.9400850577668235 1.0482386412758966 0.9803803064649291 0.9606321676429251 1.0521546912014035 0.9213143246053733 0.8837265454774552 0.9698697425004492 1.0 12.5251662790373 -7.278018054741427 24.58564190367709 0.9340381915511712 1.0073492711552872 0.2858634605204897 0.05224303894724323 801.7251305046888 1188927.349924126 0.020664837141901597 0.013984792103747642 5.2720794357363233e-08 7.278018054741427 0.07331107960411598 LNQSS(ph)PDNVTDTK ddPTM_A459_Selumetinib_30min_R2 3 LNQSSPDNVTDTK 13 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 LNQS(0.114)S(0.88)PDNVT(0.006)DTK;LNQS(0.095)S(0.905)PDNVTDTK;LNQS(0.078)S(0.922)PDNVTDTK 104.09 0.0079571 173495000.0 646830.0 604690.0 701520.0 712150.0 725920.0 544750.0 587590.0 612130.0 530870.0 609270.0 True False 610881.7780656471 651067.7786151974 656384.966957226 615153.941472729 634723.43979286 619784.3677518545 614914.0992874964 613911.1969564238 637058.8337471319 591678.7920264287 1.0324550859317612 1.1003736949660956 1.1093603079961452 1.03967549583094 1.072750026444261 1.0475014080345308 1.039270137064554 1.0375751256080208 1.0766970902662945 1.0 19.17445465888313 -6.522476108655341 1.1325122228879612 1.0408230098654858 1.0785043836783448 0.22858663637429855 0.028011947023880903 0.7342054741467147 1.9916309279790334 0.013060952712726408 0.014924466099899244 3.002782604956133e-07 6.522476108655341 0.037681373812858965 LNS(ph)IMRQDS(ph)LEPVLRDPCY(ph)L ddPTM_A459_Selumetinib_30min_R1 1 LNSIMRQDSLEPVLRDPCYL 20 2 D6RDZ7 D6RDZ7 TSC22D3 3 LNS(1)IMRQDS(1)LEPVLRDPCY(1)L 51.495 0.029395 6743200.0 1064.2 1238.8 1132.0 1251.1 1213.2 1130.3 1457.3 1196.9 668.7 846.67 True False 1088.9937894272684 1093.7607200975044 978.2806176309084 1032.6188710556198 1103.4662742078572 1118.9302082302868 1347.3746877210392 1165.1543239208745 1134.7350600843683 955.3483417641894 1.139891850773806 1.144881581180867 1.024004098677108 1.0808820468026763 1.1550407594471213 1.171227456326579 1.410349114369023 1.2196120231592678 1.187771005064933 1.0 9.899883058319796 -6.68692321982052 2.625424683221799 1.2274842199692833 1.097957357468793 0.1591340016501247 0.09948257023838214 0.3907350117518346 5.48953013571114 0.03616239420675491 0.03503246440725334 2.0562540949689922e-07 6.68692321982052 -0.12952686250049017 LNS(ph)PLLSNK ddPTM_A459_Selumetinib_30min_R2 1 LNSPLLSNK 9 0 P48552 P48552 NRIP1 Nuclear receptor-interacting protein 1 1 LNS(0.996)PLLS(0.004)NK 86.463 0.033813 3956900.0 123880.0 101970.0 110620.0 121030.0 101460.0 76639.0 99621.0 97477.0 72482.0 100120.0 True False 116995.24553093151 109790.77111477207 103502.8296339493 104545.50521160451 88713.68773609161 87195.32659042577 104253.5738952665 97760.64193181395 86980.42531629157 97229.27545699952 1.2032923723953253 1.1291945825856533 1.0645233048118754 1.0752471899046565 0.9124174516277868 0.8968011556250736 1.0722446856181043 1.0054650872622148 0.8945909028681327 1.0 16.569103150144826 -5.434371122447598 1.0935847883221848 0.9687459305586904 1.2063181575554653 0.6511046596560855 0.05789960770593261 0.49474855927380396 0.9463856691802826 0.021288470573261987 0.10579792944799844 3.6781452670859056e-06 5.434371122447598 0.23757222699677494 LNS(ph)PPSSIYK ddPTM_A459_Selumetinib_30min_R2 2 LNSPPSSIYK 10 0 C9JKH7;Q53EP0-2;Q53EP0 C9JKH7 FNDC3B Fibronectin type III domain-containing protein 3B 1 LNS(0.979)PPS(0.013)S(0.008)IYK;LNS(0.66)PPS(0.198)S(0.142)IYK 112.02 0.0084914 48106000.0 379760.0 158387.0 262225.0 264346.0 148998.0 146897.0 393550.0 256459.0 213768.0 183765.0 True False 358654.45949972956 170534.7736055251 245353.72898899307 228341.6187777147 130279.53918097958 167130.72835180207 411850.85480453115 257205.2532309268 256527.57317696832 178459.22697118984 2.009727743344031 0.9555951603054738 1.3748447371040253 1.2795170227571242 0.7300241147072305 0.9365205217367851 2.30781485381543 1.441255000350582 1.4374576060355888 1.0 17.445234970171974 LNS(ph)SENGEDR ddPTM_A459_Selumetinib_30min_R1 2 LNSSENGEDR 10 0 Q7L4I2;H0YGP9;E1B6W4;Q7L4I2-2 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 LNS(0.906)S(0.094)ENGEDR;LNS(0.5)S(0.5)ENGEDR 161.25 0.00042848 11113200.0 2510.43 3350.2 3143.9 2977.2 2741.8 2548.5 3146.8999999999996 3151.6 2180.56 2457.4 True False 2568.918134553557 2957.9570265342727 2716.975648206548 2457.2879089655426 2493.8046741041076 2522.8644038528587 2909.526799416274 3068.0093301604406 3700.2510581988477 2772.831227103024 0.926460330309209 1.0667641786567237 0.9798561202173014 0.8862017583135948 0.8993712454362267 0.9098514107866119 1.0492981941984496 1.106453685378396 1.3344667436051512 1.0 11.437144091724118 -7.653068229806789 2.4611692805714402 1.1743004659249752 0.9483499721285776 0.4977377967281663 0.0909203779041422 0.230928003277673 2.806026490485807 0.05402174184692547 0.026065026820397953 2.222960625129689e-08 7.653068229806789 -0.22595049379639753 LNS(ph)SENGEDR ddPTM_A459_Selumetinib_30min_R2 2 LNSSENGEDR 10 0 Q7L4I2;H0YGP9;E1B6W4;Q7L4I2-2 Q7L4I2 RSRC2 Arginine/serine-rich coiled-coil protein 2 1 LNS(0.968)S(0.032)ENGEDR;LNS(0.905)S(0.095)ENGEDR 141.34 0.0013192 41453000.0 33823.0 31645.0 33897.0 41491.0 43241.0 32146.0 38078.0 44432.0 34917.0 45710.0 True False 31943.253064196757 34072.069745287474 31716.103924263098 35839.85422403278 37808.67900055528 36573.819707666145 39848.702450125595 44561.28976388644 41901.37566249481 44390.23353115711 0.7196009239684688 0.7675577944723493 0.7144838267634219 0.8073815200561427 0.8517341764831606 0.8239159111878812 0.897690759435995 1.0038534654837818 0.94393230963934 1.0 15.43795467806053 -6.985810042704187 0.5877541628591624 1.005842899982402 0.7234143755082278 0.8989819621479651 0.03207482768424649 0.24622046790885402 0.1807233303313417 0.02823437076134021 0.026516634583329233 1.033213227007759e-07 6.985810042704187 -0.2824285244741742 LNS(ph)SIVEPK ddPTM_A459_Selumetinib_30min_R1 1 LNSSIVEPK 9 0 Q00653-3;Q00653-4;Q00653 Q00653-3 NFKB2 Nuclear factor NF-kappa-B p100 subunit;Nuclear factor NF-kappa-B p52 subunit 1 LNS(0.5)S(0.5)IVEPK 125.36 0.005063300000000001 7622200.0 8093.9 11355.0 5834.2 6040.6 6212.3 8385.4 9447.1 9003.8 5976.2 8355.7 True False 8282.472122012181 10025.551321203717 5041.947684966647 4985.72260610549 5650.398561870646 8301.050489334028 8734.497641096155 8764.989975535786 10141.17491562166 9428.235486410336 0.8784753132174483 1.0633539367630709 0.5347710812096289 0.5288076027897062 0.5993060493678816 0.8804458163246972 0.9264191219752498 0.9296532726796505 1.0756174822148787 1.0 13.202772077492172 -6.970971965141386 4.521939007795563 0.9698863524968301 0.7188784210791443 0.38409085726369285 0.1564754483253525 0.2553107612736558 12.450332426408762 0.06552664966847893 0.055669996661218656 1.0691238917729128e-07 6.970971965141386 -0.25100793141768574 LNSEAS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 LNSEASPSR 9 0 Q13111;Q13111-3;Q13111-2;K7EJF1 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 LNS(0.007)EAS(0.881)PS(0.112)R;LNS(0.004)EAS(0.498)PS(0.498)R 132.03 0.0034615 228670000.0 123164.0 90083.0 106058.0 126506.0 132814.0 112310.0 123788.0 120409.0 109009.0 112153.0 True False 116319.03794455627 96992.07643750134 99234.34374721932 109275.6645649779 116128.7179477751 127779.6830513279 129544.38728126869 120759.37025521693 130813.84596594478 108914.85148151111 1.0679814218385273 0.890531228002145 0.911118570125075 1.0033127996646816 1.0662340017742078 1.1732071550684637 1.1894097592673993 1.1087502632799024 1.2010652742629058 1.0 16.73284116584552 -6.34384749145134 2.226531401408794 1.14374519024301 0.9522399989433186 0.5549423409111065 0.06984995663474634 0.20789694667110806 2.02245952858652 0.023086832668049485 0.02797853374644994 4.530566491169742e-07 6.34384749145134 -0.19150519129969146 LNSEASPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LNSEASPSR 9 0 Q13111;Q13111-3;Q13111-2;K7EJF1 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 LNS(0.007)EAS(0.167)PS(0.826)R 99.732 0.018545 58121000.0 4056.7 5700.8 2976.4 2900.0 4144.9 3390.1 4889.2 4828.2 2278.5 4232.0 True False 4151.213217035897 5033.3476857699825 2572.2212281949064 2393.5694397420643 3769.9945268415327 3355.9986719645217 4520.403707682496 4700.140451796115 3866.4480849442725 4775.218423170833 0.869324258947597 1.054056011625903 0.538660433984275 0.5012481582261717 0.7894915358318179 0.702794799014885 0.9466381026149719 0.9842775838251885 0.8096903099098197 1.0 12.221351009604895 -7.265629800136242 24.59266953440629 0.9338413112997656 0.7386446218842624 0.2708557701728398 0.154687075187286 448.10178981405585 2629794.6579147773 0.06908114146996595 0.048459994150313754 5.4246309797409645e-08 7.265629800136242 -0.19519668941550317 LNSEASPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 LNSEASPSR 9 0 Q13111;Q13111-3;Q13111-2;K7EJF1 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 LNSEAS(0.124)PS(0.875)R 101.38 0.017075 39562000.0 95864.0 76646.0 85423.0 97713.0 106330.0 81657.0 99244.0 89820.0 88205.0 91494.0 True False 90536.26265399746 82524.50174426618 79926.97718153006 84404.32083567306 92971.87479773932 92904.510541557 103859.04264825521 90081.36132949845 105848.4646536173 88852.33049003908 1.018952031473695 0.9287826361911543 0.8995484613708629 0.949939302325169 1.046363942115869 1.0456057824163902 1.1688949752409532 1.0138322859139541 1.1912851814897933 1.0 16.43912199645989 -6.449177838353761 2.066021369084128 1.0915993460490963 0.9427295791552581 0.5023192313421627 0.06334917143671034 0.24995351350149111 2.1189405345384587 0.021668384306240917 0.02462009384713655 3.554857216442423e-07 6.449177838353761 -0.14886976689383813 LNSS(ph)ETADLLK ddPTM_A459_Selumetinib_30min_R1 1 LNSSETADLLK 11 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 LNS(0.215)S(0.782)ET(0.002)ADLLK 117.48 0.0055868 4689100.0 2339.9 2935.1 2590.9 2751.9 2182.5 2141.2 2600.5 2618.1 1675.3 2631.9 True False 2394.4151173471755 2591.457127509029 2239.0700107949833 2271.3323245607544 1985.0932603516715 2119.661472054048 2404.3421913254397 2548.6594832126675 2842.8617409291796 2969.7300018769647 0.80627367330829 0.8726238162631433 0.7539641682509249 0.764827887762591 0.6684423362046479 0.7137556177545952 0.8096164263437479 0.8582125249102891 0.9572795301702174 1.0 11.53611605654342 -8.08878386004224 1.6467127938152053 0.9958494552053648 0.7645964614220793 0.7299359460537427 0.05129585994125927 0.223317969314886 1.0815876463257401 0.052974808252955634 0.01685787357193361 8.151098474863557e-09 8.08878386004224 -0.23125299378328557 LNSS(ph)GSSEDSFVEIR ddPTM_A459_Selumetinib_30min_R2 1 LNSSGSSEDSFVEIR 15 0 Q96CV9-3;Q96CV9-2;Q96CV9;A0A087WY28 Q96CV9-3 OPTN Optineurin 1 LNS(0.231)S(0.462)GS(0.207)S(0.058)EDS(0.042)FVEIR 145.33 0.00036493 1224100.0 6888.3 7348.2 7731.2 7549.7 9401.1 4928.0 7253.6 7089.7 7142.4 9380.2 True False 6505.475862049687 7911.783311812972 7233.783009094103 6521.417836041077 8220.049771099653 5606.787268070019 7590.906772735728 7110.329853236979 8571.079575330152 9109.3692533135 0.7141521746616368 0.8685325066754858 0.7941036100235854 0.7159022380906268 0.9023730998839069 0.6154967607697505 0.8333076156699393 0.7805512824777218 0.9409081284318838 1.0 13.153135447732225 -8.359299136918375 2.7487120083625802 0.9998929387798977 0.7785594175722056 0.49658948222233834 0.07846627695005956 0.20866819673641993 2.962099328513975 0.07009863227122541 0.019258260490768807 4.372208488538411e-09 8.359299136918375 -0.22133352120769212 LNSS(ph)IVEPK ddPTM_A459_Selumetinib_30min_R1 1 LNSSIVEPK 9 0 Q00653-3;Q00653-4;Q00653 Q00653-3 NFKB2 Nuclear factor NF-kappa-B p100 subunit;Nuclear factor NF-kappa-B p52 subunit 1 LNS(0.355)S(0.645)IVEPK 113.24 0.0092295 8278200.0 7394.9 10549.0 5141.1 5615.0 5632.7 7899.1 7847.1 8131.3 5771.4 6516.4 True False 7567.186782029418 9313.918175902945 4442.96685804087 4634.445656604032 5123.223279533958 7819.642225808953 7255.186929263545 7915.631509815203 9793.644273621841 7352.843415111152 1.0291510854804495 1.2667097135186507 0.6042515265468503 0.6302929893868783 0.6967676299219151 1.0634854823289808 0.9867185413404956 1.0765401985233958 1.3319533302578552 1.0 12.84408654652965 -7.344066644944709 1.6050773576164554 1.1481733853118903 0.8541145368306706 0.24633907180545667 0.20683236856098192 0.6105003745372063 3.055043592008858 0.13519675962204272 0.07621889905795322 4.528280855405885e-08 7.344066644944709 -0.29405884848121966 LNSS(ph)IVEPK ddPTM_A459_Selumetinib_30min_R2 2 LNSSIVEPK 9 0 Q00653-3;Q00653-4;Q00653 Q00653-3 NFKB2 Nuclear factor NF-kappa-B p100 subunit;Nuclear factor NF-kappa-B p52 subunit 1 LNS(0.017)S(0.983)IVEPK;LNS(0.081)S(0.919)IVEPK 119.45 0.0068935 11806900.0 113204.0 84619.0 110602.0 125762.0 116503.0 159315.0 137295.0 121461.0 98243.0 133504.0 True False 106912.57487151725 91109.0052070306 103485.98773435231 108632.99864844917 101866.85158996527 181259.19513242197 143679.48954488142 121814.43140104896 117894.34513877147 129649.39263495077 0.8246284282453002 0.7027337603004667 0.7981987854407785 0.8378982457274079 0.7857102105891709 1.3980720730623637 1.1082156778739003 0.9395680837783604 0.9093320280390548 1.0 16.9842559220889 -6.62568129848369 23.635491653810746 1.0720795101684886 0.7880158149083676 0.540505883476768 0.12962838669865842 6.267103175945143 1426.2389693711602 0.04519852426002457 0.045198526818902886 2.3676565349520477e-07 6.62568129848369 -0.284063695260121 LNSS(ph)TEANVIK ddPTM_A459_Selumetinib_30min_R2 2 LNSSTEANVIK 11 0 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 LNS(0.001)S(0.998)T(0.001)EANVIK;LNS(0.015)S(0.576)T(0.408)EANVIK 208.68 1.8269e-05 18365300.0 110635.0 103559.0 115777.0 129113.0 116317.0 90189.0 99405.0 103894.0 83562.0 104307.0 True False 104486.34960699553 111501.64230533213 108328.0338684667 111527.58666765185 101704.21857282631 102611.71609577244 104027.52946727067 104196.31433942253 100276.73491735796 101295.38588786713 1.031501570295223 1.1007573674556432 1.0694271305544423 1.1010134932612987 1.0040360444987273 1.0129949671089902 1.0269720437456844 1.0286383079162826 0.9899437574418561 1.0 16.62820893378513 -6.269831225274305 24.99786535768977 1.0128180318365259 1.077020227672043 0.6941078416366293 0.021175549919575258 341.42699248826654 1017049.6230671259 0.006288278929180541 0.0072430855089286456 5.372405372404459e-07 6.269831225274305 0.06420219583551723 LNSSGS(ph)SEDSFVEIR ddPTM_A459_Selumetinib_30min_R2 1 LNSSGSSEDSFVEIR 15 0 Q96CV9-3;Q96CV9-2;Q96CV9;A0A087WY28 Q96CV9-3 OPTN Optineurin 1 LNS(0.322)S(0.03)GS(0.646)S(0.002)EDSFVEIR 148.36 0.00039025 0.0 9932.4 9727.1 11097.0 9030.6 10747.0 7175.3 7197.4 8737.1 8522.0 7744.6 True False 9380.39697054749 10473.13729244386 10383.031101500059 7800.6167013460845 9396.865780600994 8163.632444111772 7532.093361377532 8762.523514495235 10226.638124574874 7520.993275112649 1.247228474673379 1.3925204968737317 1.3805398730853862 1.0371790554791112 1.2494181867833472 1.0854460502079757 1.001475880360326 1.1650753024192793 1.3597456812540096 1.0 12.876707491571587 -5.751191930190353 24.99308545292996 1.1331848262057516 1.3453387568440789 0.4279888751470362 0.11203993813380504 200.63246279726442 489329.09768372186 0.030647267965791373 0.0523212546766145 1.773405576636283e-06 5.751191930190353 0.21215393063832733 LNSSNSAS(ph)PHR ddPTM_A459_Selumetinib_30min_R2 3 LNSSNSASPHR 11 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 LNSSNS(0.009)AS(0.991)PHR;LNSSNSAS(1)PHR;LNSSNS(0.002)AS(0.998)PHR 152.11 0.00038638 8004600.0 27176.2 16756.4 27335.5 35269.6 44259.2 32389.8 44746.1 52432.3 44167.0 39858.3 True False 25665.855598948183 18041.56199968194 25576.76369064205 30465.81963654639 38698.96361373176 36851.200944670105 46826.88231271509 52584.869312365445 53001.63412908924 38707.48731469964 0.6630721180705847 0.46610005586258857 0.6607704468827394 0.7870782050215029 0.9997797919327963 0.9520432221565416 1.2097629053522163 1.3585193191394704 1.3692863527455377 1.0 15.240325038089548 -6.438286259578293 0.8540678073270243 1.2714001128665475 0.5449393889578267 0.823471042820522 0.12189660411066448 0.23248097712382512 0.37216135280003604 0.06823018727431225 0.09180352758664104 3.6451360330793223e-07 6.438286259578293 -0.7264607239087209 LNSSSSSSSNSSNEREDFDS(ph)TSSSSSTPPLQPR ddPTM_A459_Selumetinib_30min_R2 1 LNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPR 33 1 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 LNSSSSSSSNSSNEREDFDS(0.125)T(0.125)S(0.125)S(0.125)S(0.125)S(0.125)S(0.125)T(0.125)PPLQPR 60.82899999999999 0.00032166 8460600.0 8985.2 7834.1 11871.0 11593.0 10019.0 8274.5 10108.0 8598.5 7175.0 9602.8 True False 8485.838554605465 8434.950279398225 11107.232784167545 10014.01340095953 8760.323649003565 9414.237266567645 10578.042028622029 8623.5202114417 8610.200486250258 9325.542212929233 0.9099565859924397 0.9044997155987067 1.1910549038926785 1.0738263976839628 0.9393902733996495 1.0095109808752398 1.134308524597775 0.9247205164634582 0.9232922107534721 1.0 13.186971894765902 LNSSSSSSSNSSNEREDFDSTSSS(ph)SSTPPLQPR ddPTM_A459_Selumetinib_30min_R2 1 LNSSSSSSSNSSNEREDFDSTSSSSSTPPLQPR 33 1 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 LNSSSSSSSNSSNEREDFDS(0.05)T(0.05)S(0.05)S(0.05)S(0.2)S(0.2)S(0.2)T(0.2)PPLQPR 92.901 2.7135e-09 6870600.0 9459.1 8545.0 8606.7 11318.0 11574.0 7718.4 5771.1 8777.8 7891.8 8469.6 True False 8933.401089777479 9200.374023494443 8052.954292266431 9776.46887536099 10119.970647127186 8781.539539340833 6039.467585217703 8803.341944756981 9470.380515315645 8225.06064133643 1.0861197843188128 1.1185782603542656 0.9790753701917955 1.1886196712310784 1.2303824966672667 1.0676565100575337 0.7342763596009664 1.070307238893085 1.1514055553244982 1.0 13.00581060018265 -7.008793539109221 24.99256542297494 0.9814434014112241 1.1196319612651724 0.21938359417980902 0.11667267292942507 660.3615270571269 1876848.084907727 0.044357282885508206 0.03717636507459939 9.799557395444812e-08 7.008793539109221 0.1381885598539483 LNT(ph)SDFQK ddPTM_A459_Selumetinib_30min_R1 2 LNTSDFQK 8 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 LNT(0.5)S(0.5)DFQK;LNT(0.5)S(0.5)DFQK 131.12 0.0085352 312925000.0 16041.8 16548.6 19440.8 19668.2 13962.0 15291.8 15149.1 14546.2 9475.5 12625.099999999999 True False 16415.542728090924 14611.08221876458 16800.84614067047 16233.518087839613 12699.139565191312 15137.978375843493 14006.391190389622 14160.38752328334 16079.231436861728 14245.65456388802 1.1523193023157712 1.0256518683109797 1.1793663861020276 1.1395417469261624 0.8914395269265449 1.062638315982859 0.9832044661461244 0.9940145227990557 1.1287113108597853 1.0 13.798234292146947 -6.206615882664411 24.999269546911354 1.0109937921909846 1.1211183679699543 0.40560237154805223 0.06768960814801919 321.5491415585495 146624.67296007797 0.019457026074094306 0.025118893808536363 6.214184127427355e-07 6.206615882664411 0.11012457577896972 LNT(ph)SDFQK ddPTM_A459_Selumetinib_30min_R2 2 LNTSDFQK 8 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 LNT(0.92)S(0.08)DFQK;LNT(0.975)S(0.025)DFQK 113.69 0.024885 11404200.0 60579.0 151562.0 50878.5 88374.0 60359.0 54387.0 54351.0 54474.0 43866.9 75023.0 True False 57212.26169695109 163186.31805135898 47605.03270232231 76337.3087463469 52776.16280369361 61878.31557396996 56878.429194463315 54632.51032134381 52641.5057435946 72856.89105683667 0.7852690509717059 2.239819949550895 0.6534046678602434 1.0477706039747854 0.7243812086700514 0.8493131490567972 0.7806870203958012 0.7498605763828742 0.7225329681241577 1.0 16.152777813381448 -5.30080059997586 24.98316896718815 0.8119950385491029 1.5125458746560432 0.3935875521082278 0.3458120698721679 403.0037762874621 255791.95366150409 0.08158456816285985 0.169835973857803 5.002641713078415e-06 5.30080059997586 0.7005508361069402 LNTS(ph)DFQK ddPTM_A459_Selumetinib_30min_R1 3 LNTSDFQK 8 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 LNT(0.073)S(0.927)DFQK;LNT(0.049)S(0.951)DFQK;LNT(0.08)S(0.92)DFQK 155.33 0.00061119 1213833000.0 31448.3 32935.1 36561.2 37751.9 26818.2 27952.4 28773.2 26371.6 20033.6 25484.4 True False 32180.98420226046 29079.0431808874 31596.38985629607 31159.23935593051 24392.498545137758 27671.22423474856 26602.814358563795 25672.139500970643 33995.55600374788 28755.5709790772 1.1191217251667727 1.0112490272596415 1.0987919481510513 1.0835896591516905 0.8482703599551527 0.9622908985143219 0.925136015484451 0.8927709875644587 1.1822250383580746 1.0 14.81155386413825 -6.208952730354615 24.9876332903011 0.9606137846365144 1.074878514981166 0.2731776621623795 0.08706429735467189 436.3663014208611 207743.16879740753 0.025140139666107668 0.03245575354194403 6.180836701756384e-07 6.208952730354615 0.11426473034465157 LNTS(ph)DFQK ddPTM_A459_Selumetinib_30min_R2 4 LNTSDFQK 8 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 LNT(0.092)S(0.908)DFQK;LNT(0.101)S(0.899)DFQK;LNT(0.111)S(0.889)DFQK;LNT(0.087)S(0.913)DFQK 125.23 0.005143399999999999 1471280000.0 1305691.0 1255747.0 1137342.0 1214316.0 1102979.0 940106.0 1078373.0 1076312.0 698960.0 1086566.0 True False 1233125.9213152025 1352058.75703699 1064166.6539643386 1048924.0659880606 964412.9172626311 1069597.068067417 1128519.4812555618 1079443.8897269573 838771.5305741449 1055194.0163424884 1.1686248236977892 1.281336641505506 1.0085033060109185 0.9940580118373296 0.9139673864011071 1.0136496715313574 1.0694900310060838 1.0229814356496485 0.7948979216935794 1.0 20.00907685800135 -5.331577889099627 5.507148404603096 0.9792921380310445 1.2243291199926636 0.6335462291578269 0.07549908947435988 0.12482874223257738 7.0773115013437655 0.019998828042855164 0.04319989061990522 4.660388381745229e-06 5.331577889099627 0.24503698196161905 LNTVAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 LNTVASPK 8 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 LNT(0.001)VAS(0.999)PK 88.155 0.031466 32406000.0 6273.1 7966.5 6482.9 5436.8 4956.4 5708.9 6255.8 6214.6 4498.7 6836.6 True False 6419.251024672238 7033.778476474629 5602.557788020682 4487.364941375745 4508.09449512349 5651.473649266464 5783.919969426529 6049.768620134241 7633.965327952074 7714.144204123275 0.8321403975363973 0.9118028248311738 0.7262708136861206 0.5817061261283151 0.5843933397970283 0.7326118749822831 0.7497811573622094 0.784243651667879 0.9896062513158175 1.0 12.913290399857306 -8.19819163524941 2.5747052966313486 1.0093397633068337 0.7269594589831854 0.5520795025831002 0.0935097351317376 0.24878947828938325 2.9691889876240274 0.09684478736958246 0.02893656913686024 6.335900738470409e-09 8.19819163524941 -0.28238030432364836 LNTVAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 LNTVASPK 8 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 LNT(0.008)VAS(0.992)PK;LNTVAS(1)PK;LNTVAS(1)PK;LNTVAS(1)PK 118.77 0.008207299999999999 113462300.0 728320.0 576162.0 589925.0 575860.0 554416.0 480125.0 680570.0 635360.0 442292.0 516609.0 True False 687842.8900959635 620351.7727471733 551969.8677617768 497426.87458609155 484765.3055380735 546257.8606091954 712217.8535238714 637208.7924104905 530762.7586710233 501693.1558586204 1.3710430012120816 1.2365163158055748 1.100214067734511 0.99149623385787 0.9662585583979597 1.088828608144564 1.4196284027533712 1.2701165741835614 1.057942992590066 1.0 18.936445731302868 -14.52270521085236 0.014614280891569428 1.5306682256566043e-06 2.0455192207795103 0.09050166052981357 0.14760479262668885 25912.444076799413 28.623358860746585 2494.9632046835904 1602.7485284893235 3.0011989728864623e-15 14.52270521085236 2.045517690111285 LNVSDENTASCPLS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 3 LNVSDENTASCPLSPIK 17 0 Q8N3X6-3 Q8N3X6-3 1 LNVSDENTASCPLS(1)PIK;LNVSDENTASCPLS(1)PIK;LNVSDENT(0.003)AS(0.072)CPLS(0.925)PIK 236.66 2.1966e-22 8492800.0 48468.7 47380.3 53319.1 59897.0 61198.3 47103.9 54004.3 52217.3 44141.3 55697.0 True False 45775.00368957909 51014.21665832343 49888.60715544669 51738.92527191178 53510.02243425644 53592.0346583692 56515.6069574903 52369.24369796061 52970.79341097122 54088.8828918149 0.8462922737956209 0.943155301623788 0.9223449346371355 0.9565537778880855 0.9892979772069566 0.9908142263829064 1.044865486878869 0.9682071601054545 0.979328663838741 1.0 15.723044481088161 -2.864044162896642 0.4728147408349741 1.0000469624765342 1.773736898575387e-10 0.7739346547865307 0.024022432888267393 12.730817635699552 0.5063027388055015 0.014969100257257449 10.446136657247505 0.0013675897499266156 2.864044162896642 -1.0000469622991606 LNYSDES(ph)PEAGK ddPTM_A459_Selumetinib_30min_R1 1 LNYSDESPEAGK 12 0 Q9GZR1-2;Q9GZR1 Q9GZR1-2 SENP6 Sentrin-specific protease 6 1 LNYSDES(1)PEAGK 127.66 0.0025608 9926300.0 1505.7 1655.7 1800.2 1796.7 1431.6 1601.2 1690.6 1473.4 826.4 1394.4 True False 1540.7798804178135 1461.8498742859533 1555.7427277907777 1482.9400732360584 1302.1120327695085 1585.0933817732775 1563.0766808901308 1434.3206457222966 1402.3404421320797 1573.3848226061937 0.9792771979747634 0.9291114629315598 0.9887871710963926 0.9425158117260084 0.8275864963618105 1.0074416372897823 0.9934484294192006 0.9116146445002897 0.891288909098035 1.0 10.619655856729192 -4.860046852475043 0.0009764928451962292 1.7500769981719175 0.13607126190559773 0.003492030546621172 0.05500639169959199 10240192.447683506 1595.3400366524634 1309501.226007426 1327418.209618591 1.3802353542815921e-05 4.860046852475043 -1.6140057362663198 LNYSDES(ph)PEAGK ddPTM_A459_Selumetinib_30min_R2 3 LNYSDESPEAGK 12 0 Q9GZR1-2;Q9GZR1 Q9GZR1-2 SENP6 Sentrin-specific protease 6 1 LNYS(0.004)DES(0.996)PEAGK;LNYSDES(1)PEAGK;LNYSDES(1)PEAGK 187.08 0.00010365 23440000.0 123440.0 110509.0 126180.0 119572.0 129844.0 95862.0 110603.0 106969.0 90980.0 109694.0 True False 116579.69896947182 118984.68495755993 118061.71617439669 103286.087326795 113531.83589991213 109066.12035140587 115746.25865568664 107280.26208032873 109178.54219359586 106526.84920076009 1.0943691646203313 1.116945501066326 1.1082813118024173 0.9695779805910004 1.065757945078714 1.0238369121934723 1.0865454063843727 1.007072516320733 1.0248922502892994 1.0 16.700857569929575 -5.726178591811797 24.90738032141166 1.0298442447248595 1.1075734751892425 0.5810171560146562 0.03141555528334438 122.47406323327162 86511.85788841572 0.008235063555408591 0.014262731004347738 1.8785441576763154e-06 5.726178591811797 0.07772923046438307 LPALGEAHVS(ph)PEVATADK ddPTM_A459_Selumetinib_30min_R1 2 LPALGEAHVSPEVATADK 18 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 LPALGEAHVS(0.969)PEVAT(0.031)ADK;LPALGEAHVS(0.885)PEVAT(0.115)ADK 94.271 0.0028439 16188000.0 8386.0 11531.8 6603.9 7289.0 7822.799999999999 7870.700000000001 10762.8 10757.1 5806.1 10973.5 True False 8581.377483684524 10181.65149501163 5707.12665262611 6016.112981475834 7115.229121227516 7791.5279040238165 9950.953330820003 10471.786764014745 9852.52763923412 12382.055615941663 0.693049502429642 0.8222908869754184 0.46091915830827734 0.4858735227881065 0.5746403781345315 0.6292596436081559 0.8036592339327194 0.8457228015138712 0.7957101748557144 1.0 13.595963224048399 -7.338970325908276 2.4394541040828934 0.8653873167884877 0.6028685068158045 0.5744316385198202 0.10692238881842946 0.25494428124515023 2.9666710860198515 0.05749199543068626 0.035838809840655135 4.5817319130024135e-08 7.338970325908276 -0.2625188099726832 LPALGEAHVS(ph)PEVATADK ddPTM_A459_Selumetinib_30min_R2 3 LPALGEAHVSPEVATADK 18 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 LPALGEAHVS(0.996)PEVAT(0.004)ADK;LPALGEAHVS(0.999)PEVAT(0.001)ADK;LPALGEAHVS(0.976)PEVAT(0.024)ADK 139.2 0.00021724 25568600.0 135480.0 89905.0 104084.0 124513.0 125953.0 127964.0 168433.0 170635.0 160365.0 106540.0 True False 127950.56396941065 96800.42440986153 97387.3487580907 107554.11460309432 110129.65810589347 145589.87945846416 176265.46824365776 171131.51959985506 192442.48097247668 103463.91337583614 1.2366685136355313 0.9355960088058021 0.9412687533316846 1.0395326360061443 1.0644257936179524 1.4071561253400886 1.703641999344907 1.6540213299125277 1.8599961541510894 1.0 16.658768140017642 -6.873362540264656 2.853944963583889 1.6071223008472593 1.0254024340637822 0.5352726061326041 0.22503395302676982 0.17982074436848766 2.955713711016933 0.0818912186662787 0.07133761318230857 1.3385588190285734e-07 6.873362540264656 -0.5817198667834771 LPDLS(ph)PVENK ddPTM_A459_Selumetinib_30min_R1 4 LPDLSPVENK 10 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8;A0A2R8Y7F4;A0A2R8YET2 E7EPN9 PRRC2C Protein PRRC2C 1 LPDLS(1)PVENK;LPDLS(1)PVENK;LPDLS(1)PVENK;LPDLS(1)PVENK 171.49 0.00017303 83999000.0 14860.7 21311.300000000003 12646.699999999999 13181.900000000001 13942.8 14652.0 16034.5 14957.2 7958.900000000001 14561.3 True False 15206.92539611146 18816.163088645422 10929.34760335054 10879.928619908937 12681.676201801278 14504.614182951582 14825.00475554998 14560.486468167186 13505.672004943151 16430.384694073116 0.9255367831769032 1.1452052668878119 0.6651912177864618 0.6621834377276401 0.7718429262569793 0.8827921228273972 0.9022920054268577 0.8861926692087463 0.821993657264459 1.0 14.004078638883954 -9.386459273611006 14.595403667720372 0.9999978433985891 0.8501585266641165 0.10219758362235676 0.13201890154864845 0.0 0.0 0.13846068903081238 0.03358164975704942 4.1071515328341197e-10 9.386459273611006 -0.1498393167344726 LPDLS(ph)PVENK ddPTM_A459_Selumetinib_30min_R2 3 LPDLSPVENK 10 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8;A0A2R8Y7F4;A0A2R8YET2 E7EPN9 PRRC2C Protein PRRC2C 1 LPDLS(1)PVENK;LPDLS(1)PVENK;LPDLS(1)PVENK 142.76 0.0011637000000000002 27113800.0 207068.0 179011.0 192553.0 203690.0 197571.0 165185.0 181858.0 180828.0 152672.0 183204.0 True False 195559.98951888073 192740.56808891302 180164.34961585456 175947.07061515076 172750.3646728498 187937.73434986747 190314.7573447905 181354.17954231318 183210.66601209756 177914.424498843 1.0991800696865501 1.0833330047961707 1.0126461085060936 0.9889421338981706 0.9709744735957214 1.056337814537852 1.0696982995104376 1.01933376145953 1.0297684773349505 1.0 17.440823956988645 -5.202320931286845 4.770203770035985 1.0195471825871032 1.0942425342874804 0.5230181732933692 0.027877670876232538 0.1870652486382912 8.864463561184701 0.008061401183231832 0.022491179441747604 6.275944129674322e-06 5.202320931286845 0.07469535170037722 LPDS(ph)DDDEDEETAIQR ddPTM_A459_Selumetinib_30min_R1 2 LPDSDDDEDEETAIQR 16 0 H3BRF9;Q96K21-3;Q96K21-2;Q96K21;H3BRM1;Q96K21-4 H3BRF9 ZFYVE19 Abscission/NoCut checkpoint regulator 1 LPDS(1)DDDEDEETAIQR;LPDS(1)DDDEDEETAIQR 276.63 1.4289e-52 35080000.0 266.69 490.84000000000003 624.5799999999999 599.74 324.698 511.16 449.58 743.9200000000001 345.123 638.25 True False 272.903358111594 433.3722246146746 539.765466572361 495.0066675141054 295.32912323008776 506.0181944961459 415.6678186410655 724.1888250072833 585.6485242133956 720.1756045814708 0.3789400201499348 0.6017591013326928 0.7494914617193192 0.6873416210783451 0.41007932142011105 0.702631679380778 0.5771756443799986 1.0055725581376014 0.8132023918718332 1.0 9.492204919897988 -7.755655612946864 24.999524953812966 0.9320406323714717 0.5951368760319182 0.6357658039792184 0.1222227592155845 90.2809435838371 390231.64013200457 0.059652871003486624 0.033243854013737216 1.7552718464515414e-08 7.755655612946864 -0.3369037563395535 LPDS(ph)DDDEDEETAIQR ddPTM_A459_Selumetinib_30min_R2 4 LPDSDDDEDEETAIQR 16 0 H3BRF9;Q96K21-3;Q96K21-2;Q96K21;H3BRM1;Q96K21-4 H3BRF9 ZFYVE19 Abscission/NoCut checkpoint regulator 1 LPDS(1)DDDEDEETAIQR;LPDS(1)DDDEDEETAIQR;LPDS(1)DDDEDEETAIQR;LPDS(1)DDDEDEETAIQR 292.38 8.729099999999997e-75 90926000.0 19260.5 15554.2 19580.600000000002 20021.199999999997 20735.2 12812.5 13884.8 16056.0 13498.6 16826.9 True False 18190.078515890422 16747.15712536423 18320.805513745345 17294.27802150357 18130.258800960048 14577.305574705168 14530.470712209251 16102.720301786108 16198.697182396892 16341.063675463312 1.1131514372105085 1.0248511025944216 1.1211513447104844 1.0583324540538657 1.1094907382426564 0.8920658938863025 0.889199809803524 0.9854144516898808 0.9912878074589362 1.0 13.996214274255264 -6.754237188185439 24.999998284962782 0.9467823810171223 1.0825147996163793 0.6937973665699538 0.04436657440883299 96.80048138942618 336009.9389201675 0.015103124309519777 0.014802746739503044 1.7610140130062318e-07 6.754237188185439 0.135732418599257 LPDS(ph)PALAK ddPTM_A459_Selumetinib_30min_R2 3 LPDSPALAK 9 0 E9PNJ4;G0XQ39;Q13586;H0YDB2 E9PNJ4 STIM1 Stromal interaction molecule 1 1 LPDS(1)PALAK;LPDS(1)PALAK;LPDS(1)PALAK 146.71 0.0017163 29155800.0 255373.0 71064.0 158076.0 188551.0 103545.0 132964.0 332124.0 211427.0 185291.0 118675.0 True False 241180.39099911673 76514.38029322533 147905.5622601351 162870.0285313826 90536.75139595517 151278.58407298342 347568.4240912207 212042.21756637617 222354.37746310703 115248.54439532012 2.0926979361390554 0.6639075633855237 1.2833616514304633 1.413206816501851 0.785578263664661 1.3126290216219543 3.015816172905472 1.8398689430648163 1.9293465147845819 1.0 16.814389003773293 -7.033921210175571 24.87055342380185 2.037386532805574 1.2087468133755341 0.24466497388140174 0.582137742033324 692.0835700596505 507423.85937013774 0.21041313569956568 0.1630897573470872 9.248659481537874e-08 7.033921210175571 -0.8286397194300399 LPEAS(ph)QSPLVLK ddPTM_A459_Selumetinib_30min_R1 1 LPEASQSPLVLK 12 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 LPEAS(0.66)QS(0.34)PLVLK 140.27 0.0010884 25953000.0 3243.1 4306.6 5085.1 5616.2 4406.9 4126.4 3978.0 3702.5 2332.0 3058.0 True False 3318.6579200259116 3802.381269915976 4394.5713504548885 4635.436099130823 4008.2966731013876 4084.892162471432 3677.9362572938257 3604.2976725850467 3957.2336774588734 3450.5240874424403 0.9617837278990656 1.101972098602081 1.2735953261268738 1.3434005912321134 1.1616486572833558 1.1838468762868979 1.0659065591453225 1.0445652837788433 1.1468500370307546 1.0 11.752599788851674 -7.261983773262221 24.577086779664832 1.0680442495333282 1.1799708373524211 0.20982153176558527 0.10045455558706927 67.2706374317937 3036818.0637130598 0.04369206583759965 0.03150878801847918 5.470364016763806e-08 7.261983773262221 0.11192658781909293 LPEAS(ph)QSPLVLK ddPTM_A459_Selumetinib_30min_R2 1 LPEASQSPLVLK 12 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 LPEAS(0.575)QS(0.425)PLVLK 84.169 0.033041 3575900.0 16379.0 14181.0 17534.0 18749.0 20231.0 14774.0 15565.0 15198.0 12427.0 17724.0 True False 15468.720750331984 15268.637100898151 16405.881529575738 16195.353856170992 17689.400912565252 16808.98439498101 16288.803341462388 15242.223663835657 14912.747239391205 17212.262067517582 0.8987035341231556 0.8870790510279659 0.9531508098831694 0.9409195486707314 1.027720868017 0.9765703269590796 0.9463487877169895 0.8855444800948205 0.8664025205341286 1.0 14.071149091055078 -5.26237625640176 24.613661058243622 0.9488241452749704 0.8928912888089807 0.19987736040648962 0.04534980330855564 114.59413881371756 3010740.961616116 0.012929747785701953 0.029591002297695852 5.465422540728375e-06 5.26237625640176 -0.05593285646598967 LPEASQS(ph)PLVLK ddPTM_A459_Selumetinib_30min_R1 1 LPEASQSPLVLK 12 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 LPEAS(0.123)QS(0.877)PLVLK 145.61 0.00067846 24246000.0 1936.4 2931.8 3191.0 2620.6 2701.1 2718.9 2461.7 2596.6 1110.4 1908.6 True False 1981.514352421501 2588.543493043159 2757.6797269083286 2162.9614047545024 2456.7859819179366 2691.5503345636803 2276.0119870739595 2527.7297330545107 1884.2676995927668 2153.5874013383377 0.9200993427014372 1.2019681631841455 1.2805051353822836 1.0043527387884694 1.1407876830962038 1.2497985142794892 1.0568468155318615 1.1737298107723253 0.8749436862519704 1.0 11.072526159864175 -8.257396598393223 24.987997633660353 0.9374718352588868 1.133950791480286 0.33118190291776994 0.10837297620732113 351.636333364681 2173460.5792030436 0.07741230575171527 0.026813836044182172 5.528450196987027e-09 8.257396598393223 0.19647895622139921 LPEASQS(ph)PLVLK ddPTM_A459_Selumetinib_30min_R2 2 LPEASQSPLVLK 12 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 LPEAS(0.112)QS(0.888)PLVLK;LPEAS(0.055)QS(0.945)PLVLK 144.88 0.00070617 27287000.0 84777.0 70473.0 82435.0 85285.0 80872.0 62167.0 72478.0 70507.0 62638.0 81123.0 True False 80065.43372921999 75878.0524935896 77131.22184844175 73669.03587516892 70712.13635514695 70729.93995416167 75848.37061243247 70712.16369693779 75167.35025195035 78780.76820713317 1.0163068417752559 0.963154513727111 0.9790615603753143 0.9351144645032617 0.8975811986147193 0.897807187766893 0.9627777481556065 0.8975815456764635 0.9541332480322826 1.0 16.265555864579824 -5.750723118989328 3.6291028715171394 0.9282373417807899 0.9857082904682709 0.31864249730281535 0.033564644238044096 0.23947970118163142 6.715667877202531 0.009145067852641863 0.015665252321038478 1.7753209620008873e-06 5.750723118989328 0.05747094868748104 LPEGPVDS(ph)EDDEEEDEEIDRTDPLQGR ddPTM_A459_Selumetinib_30min_R1 2 LPEGPVDSEDDEEEDEEIDRTDPLQGR 27 1 E9PCH4;Q8TEU7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RD23;D6RIH0;D6RB02;Q8TEU7-6 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 LPEGPVDS(0.996)EDDEEEDEEIDRT(0.004)DPLQGR;LPEGPVDS(1)EDDEEEDEEIDRTDPLQGR 79.416 6.061e-05 19360500.0 566.6 917.87 589.64 470.59 813.29 732.62 888.76 873.28 431.78 741.1700000000001 True False 579.8006775883201 810.4053536938136 509.5701266606791 388.4102905683512 739.728063098012 725.2505079657376 821.7201176552192 850.1177775867841 732.6991240365315 836.3063891071661 0.6932873945962683 0.9690292508215749 0.6093103356590305 0.4644353978725606 0.8845180100653537 0.8672067048776336 0.982558699010396 1.0165147470586264 0.8761132685100674 1.0 9.707887774503487 -6.499620364460118 21.786527470238152 0.9432212170786721 0.6959673596327788 0.5018928590982136 0.1249445316190327 142.0282209238558 133040.13859802674 0.04167994334854914 0.04682964151135496 3.1650431520174296e-07 6.499620364460118 -0.24725385744589334 LPEGPVDS(ph)EDDEEEDEEIDRTDPLQGR ddPTM_A459_Selumetinib_30min_R2 2 LPEGPVDSEDDEEEDEEIDRTDPLQGR 27 1 E9PCH4;Q8TEU7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RD23;D6RIH0;D6RB02;Q8TEU7-6 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 LPEGPVDS(1)EDDEEEDEEIDRTDPLQGR;LPEGPVDS(1)EDDEEEDEEIDRTDPLQGR 126.45 3.9159e-12 12226900.0 13765.9 9702.3 15234.5 15944.7 17821.8 16423.9 14600.8 12949.900000000001 14654.2 12767.9 True False 13000.846387263877 10446.435212188424 14254.328856069455 13773.00435385831 15582.866155086507 18686.143143680016 15279.766130936338 12987.582065028646 17585.449472558685 12399.257552011835 1.0485181336647396 0.8425048974398829 1.1496114824840158 1.110792666099881 1.2567580026239649 1.5070372613276433 1.2323129886480282 1.0474483662065195 1.4182663275435687 1.0 13.597966116443965 -5.662263036887661 1.6986587515299116 1.2523328193090426 0.9491155590527462 0.3281846367324158 0.1545932220220191 0.411494395245356 2.37751920638714 0.04780517111637555 0.11498286367273292 2.1763912095075043e-06 5.662263036887661 -0.30321726025629636 LPELDPRGS(ph)DEENLDSETSASTESLLEER ddPTM_A459_Selumetinib_30min_R1 1 LPELDPRGSDEENLDSETSASTESLLEER 29 1 M0R300;M0R0P8;Q13459-2;Q13459;M0R240;M0QXP0 M0R300 MYO9B Unconventional myosin-IXb 1 LPELDPRGS(0.995)DEENLDSET(0.001)S(0.001)AS(0.001)T(0.001)ESLLEER 55.691 0.0037636 15695000.0 2831.5 3238.3 3053.8 3159.1 3414.8 3118.2 3025.0 2624.7 1514.8 2512.1 True False 2897.468440860091 2859.158330555175 2639.1107333226764 2607.422488651434 3105.9319429319066 3086.8337390990714 2796.8218145585292 2555.084429772848 2570.5049633853782 2834.5525049261437 1.0221960735687932 1.0086806737875798 0.9310502200034007 0.9198709440449656 1.0957397816883387 1.089002138339117 0.9866890134149773 0.9014066330866652 0.9068468334659953 1.0 11.468905277366794 -7.609548904987996 5.948078787911623 0.9291872577324616 1.009435647534784 0.24298534188113585 0.058680688207169346 0.31127882739273555 16.954176950386074 0.03098811838248621 0.017626829819667574 2.4572599087657043e-08 7.609548904987996 0.08024838980232252 LPGPPPAS(ph)PIPTEGPR ddPTM_A459_Selumetinib_30min_R1 2 LPGPPPASPIPTEGPR 16 0 Q9H6A9-3;Q9H6A9 Q9H6A9-3 PCNXL3 Pecanex-like protein 3 1 LPGPPPAS(0.981)PIPT(0.019)EGPR;LPGPPPAS(1)PIPTEGPR 115.58 0.0019885 14519900.0 916.3599999999999 1016.1000000000001 1224.83 1237.1 1174.16 1049.67 1150.85 1073.96 818.54 1024.1100000000001 True False 937.709405073831 897.134539627926 1058.5048135095983 1021.0637082430725 1067.957435314785 1039.1112728241044 1064.040457945349 1045.475092086275 1389.0025962037673 1155.5644941761532 0.8114730158288227 0.7763604231086453 0.9160066952941882 0.8836059894441707 0.9241867855036281 0.8992239533674208 0.9207971197695416 0.9047310620526073 1.2020121795054297 1.0 10.17438206617385 -7.073701563998095 0.45514259380868693 1.060462481683788 0.8063102697532172 0.5241307740696745 0.0756357772886675 0.9303818223433143 0.42175926018225524 0.07541179852028027 0.08665130604186157 8.439144748875376e-08 7.073701563998095 -0.2541522119305708 LPGPPPAS(ph)PIPTEGPR ddPTM_A459_Selumetinib_30min_R2 2 LPGPPPASPIPTEGPR 16 0 Q9H6A9-3;Q9H6A9 Q9H6A9-3 PCNXL3 Pecanex-like protein 3 1 LPGPPPAS(0.999)PIPT(0.001)EGPR;LPGPPPAS(1)PIPTEGPR 144.15 0.00038995 11854800.0 9831.4 4305.6 9814.900000000001 4269.6 7265.1 4072.4 6109.400000000001 4165.0 4555.299999999999 4750.9 True False 9285.01014621246 4635.825675313947 9183.42001965513 3688.073114529184 6352.393187181938 4633.33613443351 6393.499205546437 4177.119460447132 5466.487285716486 4613.729172679374 2.0124740310277662 1.004789293390999 1.9904549391489221 0.7993692253044352 1.376845703210805 1.0042496993257082 1.3857552028424507 0.9053672862252803 1.1848305527092486 1.0 12.171717604526089 -1.522878745280346 0.4670783701729674 1.0936393162936608 19.579290771380535 0.33075998410937124 0.334367285758454 113.24632367161017 1.3108023771907316 0.1852159279946004 2017.5208327692776 0.029999999999999413 1.522878745280346 18.485651455086874 LPISSS(ph)TSNLHVDR ddPTM_A459_Selumetinib_30min_R1 2 LPISSSTSNLHVDR 14 0 Q86TV6;Q86TV6-2;G3V3H1 Q86TV6 TTC7B Tetratricopeptide repeat protein 7B 1 LPIS(0.002)S(0.008)S(0.93)T(0.059)SNLHVDR;LPIS(0.012)S(0.257)S(0.729)T(0.003)SNLHVDR 144.15 0.000352 9709900.0 5051.7 6445.4 5460.5 5047.8 4755.4 5097.5 5721.799999999999 4784.6 4150.8 6236.799999999999 True False 5169.394781102925 5690.769571614834 4718.994092379481 4166.296488941381 4325.274909634061 5046.223778159687 5290.200019352393 4657.696865428877 7043.604437562729 7037.354031576522 0.7345651160802644 0.808651880533567 0.6705636907288467 0.5920259902013255 0.614616642878361 0.7170626567197474 0.7517314029698278 0.6618534245299934 1.0008881755782302 1.0 12.780817377861396 -8.26500055912989 24.96439179314838 1.0004441466817897 0.6935954860394692 0.8027851198208278 0.06077780754590578 144.4292897803164 1012446.0851892775 0.05755059365952614 0.0171407253459182 5.432496320884227e-09 8.26500055912989 -0.3068486606423205 LPISSS(ph)TSNLHVDR ddPTM_A459_Selumetinib_30min_R2 2 LPISSSTSNLHVDR 14 0 Q86TV6;Q86TV6-2;G3V3H1 Q86TV6 TTC7B Tetratricopeptide repeat protein 7B 1 LPISS(0.004)S(0.977)T(0.019)SNLHVDR;LPIS(0.002)S(0.05)S(0.919)T(0.028)SNLHVDR 187.56 5.8668e-05 11536100.0 28988.0 21417.0 42638.0 37683.0 43031.0 32574.0 31244.0 31054.0 27843.0 33585.0 True False 27376.963008158225 23059.615033490976 39894.71750074428 32550.510393199183 37625.061077979066 37060.772822668965 32696.90790881148 31144.361998733533 33412.37799842034 32615.313785690472 0.8393898396332308 0.7070180340747808 1.223189749541749 0.9980130992172235 1.1536010760223485 1.1362997476028847 1.0025017120380062 0.9548999651935803 1.024438342613143 1.0 14.993261888030249 -5.24949207251772 24.998928924309446 1.0615766686449417 0.7732039093720547 0.6457487286895589 0.08544766791146749 457.92055614605493 958163.5025792777 0.02204440104137597 0.05737435924003267 5.629993941239099e-06 5.24949207251772 -0.28837275927288697 LPISSST(ph)SNLHVDR ddPTM_A459_Selumetinib_30min_R2 1 LPISSSTSNLHVDR 14 0 Q86TV6;Q86TV6-2;G3V3H1 Q86TV6 TTC7B Tetratricopeptide repeat protein 7B 1 LPIS(0.005)S(0.02)S(0.335)T(0.63)S(0.009)NLHVDR 101.3 0.011367 5030000.0 8419.2 9217.6 11390.0 13195.0 14879.0 11313.0 8854.4 11573.0 9277.4 14002.0 True False 7951.294568727947 9924.560280744576 10657.179800494341 11397.81823735539 13009.767000052314 12871.263060810898 9266.147144660743 11606.675513986718 11133.139232214378 13597.725878434961 0.5847517915725998 0.729869124401473 0.7837472159514467 0.8382150323703413 0.9567604992453106 0.9465746828463293 0.6814482971271102 0.8535747534368295 0.818750085988331 1.0 13.731077770860404 -4.859130569006038 1.187971937759206 0.8627267781730812 0.4860004357485608 0.5302690969425734 0.08465276277333708 1.16647373629313 1.5364394932416312 0.02708940285711942 0.5288346512227039 1.383150477455339e-05 4.859130569006038 -0.3767263424245204 LPLLPPES(ph)PGPLR ddPTM_A459_Selumetinib_30min_R1 2 LPLLPPESPGPLR 13 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;A0A669KAX5 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LPLLPPES(1)PGPLR;LPLLPPES(1)PGPLR 93.649 0.016834000000000002 70012000.0 3001.5 3569.7 3227.1000000000004 2789.3 3607.2 2844.0 2719.9 2958.6 1821.92 2842.8999999999996 True False 3071.4291100976748 3151.757864491494 2788.877545191435 2302.201116645705 3280.9293969028854 2815.3919421453943 2514.7357531959483 2880.1283171127934 3091.6651722280735 3207.8139071910105 0.9574835694840029 0.9825251575305366 0.8694012888152773 0.717685371799412 1.0227929337010389 0.8776668546246036 0.7839406605098328 0.897847693301772 0.9637919348430517 1.0 11.647374734759172 -10.82080153598443 6.12449397412144 1.0000053506745574 0.8932725398267961 0.10842245241415749 0.08800921717358164 6.5719306464151505e-06 7.533704930808622e-07 0.08709582323491312 0.021122781166865272 1.5107703887212608e-11 10.82080153598443 -0.10673281084776132 LPLLPPES(ph)PGPLR ddPTM_A459_Selumetinib_30min_R2 4 LPLLPPESPGPLR 13 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;A0A669KAX5 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LPLLPPES(1)PGPLR;LPLLPPES(1)PGPLR;LPLLPPES(1)PGPLR;LPLLPPES(1)PGPLR 158.52 0.00036458 22559900.0 58146.0 35924.0 47632.0 52994.0 42976.3 33058.3 58222.0 45999.0 38284.6 42061.0 True False 54914.478096880375 38679.255286133935 44567.40897780038 45776.12578025095 37577.232981003304 37611.78075163132 60929.43836470432 46132.84947445562 45942.58976110057 40846.58964239771 1.3444079071874475 0.9469396496687171 1.0910925335010235 1.1206841545649262 0.9199601070733969 0.9208059003435444 1.491665250345922 1.1294174098336698 1.124759500445867 1.0 15.317928009661188 LPLPDDEHDLS(ph)DR ddPTM_A459_Selumetinib_30min_R1 3 LPLPDDEHDLSDR 13 0 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2;A0A5F9ZHE1;A0A5F9ZH87;H0Y325;F8WAI0;Q5JV20;Q8NF91-9;H0Y326;Q8NF91-3;Q8NF91-11;Q8NF91-8;A0A5F9ZHB2 Q8NF91 SYNE1 Nesprin-1 1 LPLPDDEHDLS(1)DR;LPLPDDEHDLS(1)DR;LPLPDDEHDLS(1)DR 113.14 0.0030893 8968200.0 2047.06 2795.4300000000003 1788.5500000000002 1771.2 2101.14 1938.94 2462.4 2647.48 1315.24 2607.42 True False 2094.752515114624 2468.1397560398495 1545.6747338019093 1461.8931695417748 1911.0922579863952 1919.436024016662 2276.659185510386 2577.2602301729794 2231.8662186710994 2942.1077554215726 0.711990412742197 0.8389018898072927 0.5253630601916655 0.4968863451203884 0.6495656912853472 0.6524016737590997 0.7738191034353075 0.87599110719984 0.7585943154387617 1.0 11.522634371283875 -7.452934774499389 2.032238050767744 0.8689396237867134 0.6397588767625138 0.50318785935824 0.10402610919186162 0.3219394301922439 2.60842999052343 0.06347125502110136 0.03465731701416923 3.524237966342875e-08 7.452934774499389 -0.22918074702419966 LPLPDDEHDLS(ph)DR ddPTM_A459_Selumetinib_30min_R2 4 LPLPDDEHDLSDR 13 0 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2;A0A5F9ZHE1;A0A5F9ZH87;H0Y325;F8WAI0;Q5JV20;Q8NF91-9;H0Y326;Q8NF91-3;Q8NF91-11;Q8NF91-8;A0A5F9ZHB2 Q8NF91 SYNE1 Nesprin-1 1 LPLPDDEHDLS(1)DR;LPLPDDEHDLS(1)DR;LPLPDDEHDLS(1)DR;LPLPDDEHDLS(1)DR 124.46 0.0014921 10008200.0 32777.899999999994 17140.399999999998 27531.7 34217.0 28697.999999999996 25261.500000000004 49556.0 38227.7 44764.8 26197.899999999998 True False 30956.235538329976 18455.013564927332 25760.340396248466 29556.58557238267 25092.70067662486 28741.0423239348 51860.45219335109 38338.93627806357 53719.010833016786 25441.49855668128 1.2167614839732173 0.7253901936559 1.0125323529530637 1.1617470372876568 0.9862901990903039 1.129691407913824 2.038419713281073 1.5069448913415224 2.1114719604010688 1.0 14.634896030384743 -7.1263921000088475 5.885391464488486 1.7034917463832118 1.016197743155675 0.4945055768030867 0.31004210733713183 0.1758895793550224 7.698029173961717 0.11102918616479568 0.08581035183429704 7.474943252741615e-08 7.1263921000088475 -0.6872940032275368 LPLPS(ph)PALEYTLGSR ddPTM_A459_Selumetinib_30min_R1 2 LPLPSPALEYTLGSR 15 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 LPLPS(0.993)PALEYT(0.005)LGS(0.002)R;LPLPS(1)PALEYTLGSR 168.45 6.595800000000001e-05 68100000.0 1386.01 2312.2 2049.0 1800.74 2000.3600000000001 1931.46 1970.6 1722.9499999999998 1127.62 1264.3600000000001 True False 1418.301336294013 2041.4865490873838 1770.7570543513518 1486.274563076251 1819.4277911922434 1912.0312660253653 1821.9560554608377 1677.251769069656 1913.4887818937273 1426.6529219093268 0.9941460284508886 1.4309623018577 1.241196809088998 1.0417912726012792 1.2753121402206613 1.3402217432579495 1.2770843051458278 1.175655089834286 1.341243376372759 1.0 10.478418681322886 -10.700518553320002 4.819549340029898 0.999973970195891 1.23926655477982 0.23338354555228757 0.12774922778559447 88338125.48484486 2.1931261024760396 25518.00283156636 0.029835890518366475 1.9928813672622622e-11 10.700518553320002 0.2392925845839291 LPLPS(ph)PALEYTLGSR ddPTM_A459_Selumetinib_30min_R2 2 LPLPSPALEYTLGSR 15 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 LPLPS(1)PALEYTLGSR;LPLPS(0.878)PALEY(0.015)T(0.044)LGS(0.064)R 102.29 0.0063899 43010000.0 35014.0 27750.0 19666.0 28965.0 24939.0 17992.1 29346.0 24284.0 17150.2 24474.0 True False 33068.06205214752 29878.335769686444 18400.71097072184 25019.917032588008 21805.939862511237 20470.34845897778 30710.647147995827 24354.66241956738 20580.719216625672 23767.372028911384 1.391321767165612 1.257115668208563 0.7742004857894526 1.0527001892406527 0.9174737466130375 0.861279422650388 1.2921347429845598 1.0247099422662966 0.8659232157257704 1.0 14.536694772082813 -5.068447983782431 5.944098900234428 0.9831018436991747 1.3616610692888529 0.5308929765275725 0.13419824119703752 0.1508164526617919 9.934969173866646 0.03481647664621553 0.098322374719387 8.541851485567588e-06 5.068447983782431 0.37855922558967814 LPLQES(ph)EEEEREER ddPTM_A459_Selumetinib_30min_R1 2 LPLQESEEEEREER 14 1 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6;C9JBL0 P23497-5 SP100 Nuclear autoantigen Sp-100 1 LPLQES(1)EEEEREER;LPLQES(1)EEEEREER 165.89 0.0011534000000000002 20478800.0 2712.3 3146.8 2023.6100000000001 2200.6000000000004 2478.83 2370.04 2695.75 3007.8 1495.82 2943.8999999999996 True False 2775.4913127829172 2778.37119309237 1748.8148768940664 1816.3065203780652 2254.620264172983 2346.199549424144 2492.4074071392233 2928.0233732886695 2538.2972896297297 3321.7782410143236 0.83554382966137 0.8364107991278728 0.5264694841158499 0.5467874098131987 0.6787389466084653 0.706308302118241 0.7503232384285089 0.8814626265944174 0.764138092750781 1.0 11.697740048128598 -8.297323868872422 0.7296171992802787 0.9835223463512753 0.6783686279562653 0.43253943754761504 0.10463732106167947 0.6693686398376432 0.8007446648842489 0.11111118580043056 0.04514661366345484 5.042850939406148e-09 8.297323868872422 -0.30515371839501004 LPLQES(ph)EEEEREER ddPTM_A459_Selumetinib_30min_R2 1 LPLQESEEEEREER 14 1 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6;C9JBL0 P23497-5 SP100 Nuclear autoantigen Sp-100 1 LPLQES(1)EEEEREER 112.02 0.017781 6913600.0 15974.0 11521.0 12101.0 14119.0 14025.0 11903.0 13349.0 10704.0 12722.0 11165.0 True False 15086.229028988539 12404.623654146228 11322.434834572603 12195.967843366487 12263.05411490917 13542.53020532416 13969.754950541692 10735.146867857406 15266.755482379906 10842.63743984619 1.3913800136438526 1.1440596186090122 1.0442509857392428 1.124815609765468 1.1310028748026761 1.24900701332648 1.2884093033677848 0.9900863076363909 1.4080296945349557 1.0 13.40442811027897 -11.493504566791767 2.85891369833226 0.8476805893753838 1.184845763872436 0.162369278364613 0.13159553934152757 27637483.20022671 18117389.18513928 27566774.063094046 0.032029825585968924 3.209929050259757e-12 11.493504566791767 0.3371651744970521 LPLQLDDAVRPEAEGEEEGR ddPTM_A459_Selumetinib_30min_R2 2 LPLQLDDAVRPEAEGEEEGR 20 1 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 ; 93.342 0.003574000000000001 10609700.0 5868.200000000001 8200.3 7608.4 9065.1 10600.7 7290.7 6100.9 5968.299999999999 6718.5 7526.0 False True 5542.068936265842 8829.236641879634 7118.883827399575 7830.417741830261 9268.945294539582 8294.927746614869 6384.603938704003 5985.666764894745 8062.387730574543 7308.704825103666 0.7582833167964522 1.208043949394878 0.9740280935888804 1.0713824034779234 1.2682062713359221 1.134938124484623 0.8735616079027305 0.8189777680356444 1.1031212675168047 1.0 12.835400053637015 -10.308174902208576 4.3604819464065585 0.9999998863930994 1.0288460765180019 0.0008907120521075562 0.15885655089608242 23071516.511720665 18180473.171213347 26.358960489355802 0.03933500863299139 4.91841417864399e-11 10.308174902208576 0.028846190124902416 LPLS(ph)PPLVEDSAFEPSR ddPTM_A459_Selumetinib_30min_R1 4 LPLSPPLVEDSAFEPSR 17 0 O96007 O96007 MOCS2 Molybdopterin synthase catalytic subunit 1 LPLS(1)PPLVEDSAFEPSR;LPLS(1)PPLVEDSAFEPSR;LPLS(0.999)PPLVEDS(0.001)AFEPSR;LPLS(1)PPLVEDSAFEPSR 146.86 0.00041253 28970300.0 5097.12 6656.54 3481.09 4162.04 4488.33 5094.84 6050.95 5325.78 2743.13 5207.21 True False 5215.872978730989 5877.189202258508 3008.377098258638 3435.2178451669174 4082.3613439790224 5043.590535344595 5594.521969852206 5184.5230138284915 4654.89125971173 5875.60612602065 0.8877165805297988 1.000269431987765 0.5120113625274795 0.5846576117404716 0.694798333383839 0.8583949344406531 0.9521608238980422 0.8823809667684097 0.7922401808210263 1.0 12.520521972067097 -6.873994223368108 5.002620735654539 0.897699946463584 0.7302475433542682 0.25502574519657095 0.13887329708256677 0.34696224247850643 13.794703894920922 0.0549504604426929 0.04848857082110561 1.3366132949708967e-07 6.873994223368108 -0.16745240310931575 LPLS(ph)PPLVEDSAFEPSR ddPTM_A459_Selumetinib_30min_R2 2 LPLSPPLVEDSAFEPSR 17 0 O96007 O96007 MOCS2 Molybdopterin synthase catalytic subunit 1 LPLS(1)PPLVEDSAFEPSR;LPLS(0.993)PPLVEDS(0.003)AFEPS(0.004)R 79.347 0.017786 7184100.0 12450.0 9171.9 12067.7 11681.5 13405.8 12047.3 9424.099999999999 13876.6 13492.3 10815.8 True False 11758.078841298808 9875.35523769323 11291.2773203183 10090.459548288518 11721.643554627413 13706.706220499165 9862.339323499886 13916.978608605208 16191.137006360184 10503.519751176746 1.1194417795026768 0.9401948557850676 1.0749993895192418 0.9606741156609001 1.1159729150139597 1.3049631499920353 0.9389556603056775 1.32498238098196 1.5414963164653672 1.0 13.358585238551399 -6.942143465032227 0.9167663344392388 1.271472391071805 1.0186487197966756 0.2115528215330893 0.16832152191870275 0.8314973882719815 1.4679412470655777 0.11192318050328175 0.08610287573295818 1.1425008582038909e-07 6.942143465032227 -0.2528236712751295 LPLS(ph)PPLVEDSAFEPSRK ddPTM_A459_Selumetinib_30min_R1 2 LPLSPPLVEDSAFEPSRK 18 1 O96007 O96007 MOCS2 Molybdopterin synthase catalytic subunit 1 LPLS(1)PPLVEDSAFEPSRK;LPLS(1)PPLVEDSAFEPSRK 156.72 1.1688e-05 106809000.0 6952.4 8461.099999999999 8925.400000000001 9230.4 8400.400000000001 7842.5 8665.599999999999 8261.8 4527.6 7055.2 True False 7114.377392984532 7470.470478541329 7713.379703712821 7618.483916067292 7640.585303211083 7763.611570420271 8011.946815285417 8042.670225891458 7683.006517179585 7960.80364346759 0.8936757784275196 0.938406574651717 0.9689197283545866 0.9569993504762304 0.9597756263566092 0.9752296273242301 1.006424372978951 1.0102837082900602 0.9651043866009738 1.0 12.958698362908649 -1.7909655659088388 0.3592642280801814 0.9963866549225986 3.991323149912655e-13 0.7856927630352537 0.015308801143856686 24.798827053415295 0.4174446881212103 0.01341286379301639 16.39633763928823 0.01618208336128853 1.7909655659088388 -0.9963866549221995 LPLS(ph)PPLVEDSAFEPSRK ddPTM_A459_Selumetinib_30min_R2 3 LPLSPPLVEDSAFEPSRK 18 1 O96007 O96007 MOCS2 Molybdopterin synthase catalytic subunit 1 LPLS(1)PPLVEDSAFEPSRK;LPLS(1)PPLVEDSAFEPSRK;LPLS(1)PPLVEDSAFEPSRK 123.63 0.0004536 8049600.0 40539.0 37202.0 38295.0 36457.0 42751.0 27986.2 34576.4 36490.9 31109.0 40672.0 True False 38286.0046704749 40055.273776716225 35831.141392443424 31491.493708167134 37380.237181210854 31841.045016570846 36184.271111836795 36597.082477606324 37331.6692580849 39497.693681453115 0.969322537646111 1.014116776026468 0.9071704713044704 0.7972995578461979 0.9463903761743803 0.8061494747862306 0.9161109862176029 0.9265625171120099 0.945160736704348 1.0 15.269480794574092 -10.629700785644383 7.869099558834134 1.0000000082666847 0.9117250135564946 0.1390332401937595 0.06373436606338906 9.740264744932216e-09 1.1066887460937842e-09 0.06493634968583828 0.0157493767505289 2.345844466977869e-11 10.629700785644383 -0.08827499471019007 LPLVPES(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 LPLVPESPR 9 0 C9J0I9;Q86WB0;Q86WB0-2;Q86WB0-3 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LPLVPES(1)PR;LPLVPES(1)PR;LPLVPES(1)PR;LPLVPES(1)PR 155.26 0.00082084 66594000.0 5466.3 5556.41 5700.17 6358.15 6758.199999999999 5718.900000000001 6086.0 5912.4 4325.42 4379.0599999999995 True False 5593.65415443176 4905.862934095068 4926.11822279256 5247.818459757248 6146.92200325712 5661.373058345742 5626.928120133288 5755.583945818182 7339.921823822537 4941.155006656534 1.132053972582565 0.9928575257173835 0.9969568281416558 1.0620631112943408 1.2440253331409807 1.1457590483842255 1.1387880187026933 1.1648256203386618 1.4854668218128102 1.0 12.27063259926698 -6.1652246255873235 5.2509675406436935 1.1990060919800303 1.0354470512110692 0.2736653061408215 0.12008318959175698 0.294927191932062 12.665907281595324 0.03509521213143084 0.04569261243645375 6.835580062843281e-07 6.1652246255873235 -0.1635590407689611 LPLVPES(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 LPLVPESPR 9 0 C9J0I9;Q86WB0;Q86WB0-2;Q86WB0-3 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LPLVPES(1)PR;LPLVPES(1)PR;LPLVPES(1)PR;LPLVPES(1)PR;LPLVPES(1)PR 150.04 0.0013618 53085300.0 47204.1 47642.8 58294.0 72314.8 61663.4 41455.1 54290.8 66072.8 56027.8 53905.2 True False 44580.68509498421 51296.8495642529 54543.42750570822 62465.399490011994 53916.69241420965 47165.1637330701 56815.42977517934 66265.06090905909 67234.92554753058 52348.81681347035 0.8516082656430307 0.9799046604440779 1.0419228327558523 1.1932533205590705 1.0299505451350688 0.9009786009324589 1.0853240480606172 1.2658368410727445 1.28436380495671 1.0 15.675869309320067 -7.564098711809317 5.752758508235181 1.2033818743500124 1.0092679288833286 0.34678055866782387 0.11168528138225896 0.20745061531278705 17.166404672476723 0.054879628817043336 0.03158629355349172 2.7283575775468674e-08 7.564098711809317 -0.1941139454666838 LPLVPES(ph)PRR ddPTM_A459_Selumetinib_30min_R1 7 LPLVPESPRR 10 1 C9J0I9;Q86WB0;Q86WB0-2;Q86WB0-3 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR 131.79 0.0013088 289156800.0 19378.399999999998 21863.9 23622.6 23870.0 21056.600000000002 18771.07 20564.82 17993.5 10582.37 16182.659999999998 True False 19829.879016197498 19304.064423748656 20414.78066965362 19701.552595394165 19152.034247844676 18582.2500785679 19013.59907056844 17516.25392887482 17957.5089842755 18259.86204345693 1.0859818638828738 1.0571856664528247 1.118013959857318 1.0789540768986168 1.0488597450662251 1.017655556999484 1.0412783527782237 0.9592763563704705 0.9834416569817529 1.0 14.156388245092154 -6.941567324431866 0.9804326042058499 0.9823171930382074 1.0868374716208822 0.7717681422537099 0.022356361398085653 0.2527266507717982 0.5084802803770608 0.014429873151574011 0.01099996019990614 1.1440175202073987e-07 6.941567324431866 0.10452027858267476 LPLVPES(ph)PRR ddPTM_A459_Selumetinib_30min_R2 7 LPLVPESPRR 10 1 C9J0I9;Q86WB0;Q86WB0-2;Q86WB0-3 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR;LPLVPES(1)PRR 153.49 0.00030463 315745200.0 268637.1 267473.0 313295.5 299300.8 316007.2 241285.6 231628.3 246867.9 206406.7 275401.9 True False 253707.32542151617 287987.31903875107 293138.4086203495 258535.51471732117 276307.550395788 274520.5012274016 242399.4749127693 247586.2447178189 247693.80748506062 267450.3315669295 0.9486147350616607 1.0767880426675864 1.0960480284429617 0.9666673927926037 1.0331172475164494 1.0264354492254677 0.9063345462785817 0.925727940837719 0.9261301193155379 1.0 18.028911466678245 -7.249936968284157 23.534855424519893 0.9333588150949976 1.0279833485921932 0.433722219743478 0.047312069735069934 293.34334414333006 600204.7432873773 0.018120417561544516 0.01389102490474617 5.624229470216483e-08 7.249936968284157 0.09462453349719557 LPLVT(ph)PHTQCR ddPTM_A459_Selumetinib_30min_R2 1 LPLVTPHTQCR 11 0 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 LPLVT(1)PHTQCR 92.039 0.034667 5964800.0 44959.0 41599.0 40555.0 53420.0 47370.0 34500.0 40999.0 34012.0 34852.0 37127.0 True False 42460.35876513682 44789.50953813288 37945.73545294539 46144.103845359976 41418.957106826914 39252.06184018171 42905.53473797728 34110.96928901029 41823.37384624307 36055.04704246926 1.1776536781417242 1.2422535320887333 1.0524389389438067 1.2798237037662663 1.1487700198543493 1.0886703820950971 1.190000797598151 0.9460802879782949 1.159986666970072 1.0 15.137913603883531 -7.4716669872117745 0.6437988552561477 1.0220996955650088 1.1901398825387761 0.30525427841106 0.08360120637828035 0.8907269670861602 0.7317163069066814 0.07241369985006105 0.044379306791080715 3.37546036471681e-08 7.4716669872117745 0.16804018697376732 LPNGLGGPNGFPKPTPEEGPPELNRQS(ph)PNSSSAAASVASR ddPTM_A459_Selumetinib_30min_R1 2 LPNGLGGPNGFPKPTPEEGPPELNRQSPNSSSAAASVASR 40 2 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 LPNGLGGPNGFPKPT(0.022)PEEGPPELNRQS(0.954)PNS(0.016)S(0.007)S(0.001)AAASVASR;LPNGLGGPNGFPKPT(0.156)PEEGPPELNRQS(0.798)PNS(0.029)S(0.012)S(0.005)AAAS(0.001)VASR 77.123 4.9204e-09 121976000.0 1896.45 1779.52 2219.91 2092.56 1929.02 1812.8400000000001 1849.16 1866.58 1272.44 1408.88 True False 1940.6335951506699 1571.172971123596 1918.4584150927815 1727.133678216089 1754.5404815961417 1794.6044755270225 1709.6763724327425 1817.072234893664 2159.237744659421 1589.7234716533371 1.2207365807667045 0.98833098909306 1.206787500657303 1.0864365463635277 1.1036765279507337 1.1288783914479201 1.0754551989187482 1.1430115157096352 1.3582473827437298 1.0 10.634560118869699 -8.012044352987827 24.92554534399077 1.2029589380528423 1.1129814883512288 0.047851827858805374 0.10183685806300408 1111.4398179717784 2300089.591367385 0.05671518487620828 0.02390406661829339 9.726478855524159e-09 8.012044352987827 -0.08997744970161348 LPNLSS(ph)PSAEGPPGPPSGPAPR ddPTM_A459_Selumetinib_30min_R2 1 LPNLSSPSAEGPPGPPSGPAPR 22 0 O60784-3;O60784-4;O60784;O60784-2 O60784-3 TOM1 Target of Myb protein 1 1 LPNLS(0.166)S(0.607)PS(0.225)AEGPPGPPS(0.001)GPAPR 80.98 0.004815 0.0 4045.6 4695.9 5204.3 4894.9 5504.9 3800.1 4256.9 4772.7 4777.4 4243.1 True False 3820.761747819958 5056.0604303016435 4869.461004013408 4228.206175826519 4813.325247569593 4323.529281126798 4454.854284887324 4786.587766836981 5733.0134917089845 4120.590678102228 0.9272364197988338 1.2270232171253308 1.1817385866280896 1.0261165221520752 1.1681153561669488 1.0492498816014493 1.0811203132991225 1.1616266066595782 1.391308659259835 1.0 12.008635444227776 -8.00064802282536 23.267226843773187 1.2225920573888818 1.102742509180665 0.09898800109327022 0.11998962845202556 16.570334129237022 594897.3792205444 0.06286122260019192 0.02953800054536056 9.985089849714571e-09 8.00064802282536 -0.1198495482082167 LPNS(ph)IASR ddPTM_A459_Selumetinib_30min_R1 2 LPNSIASR 8 0 Q9ULT0;Q9ULT0-4;H7C055;G5E9G4 Q9ULT0 TTC7A Tetratricopeptide repeat protein 7A 1 LPNS(0.996)IAS(0.004)R;LPNS(0.986)IAS(0.014)R 110.54 0.011981 29153000.0 3653.7999999999997 5902.799999999999 4403.1 5244.9 4509.5 4826.799999999999 4447.0 3377.8 2208.7 3457.6 True False 3738.9264309428218 5211.697431862732 3805.1832044970415 4328.976673966607 4101.616521216888 4778.24677438375 4111.559209699762 3288.209771359289 3748.002582934568 3901.4166398760553 0.9583509724974167 1.3358474402847431 0.9753337199633025 1.1095909700390614 1.0513146633186023 1.224746602438121 1.0538631449089175 0.8428245621733321 0.9606773459226439 1.0 11.929782359463013 -7.575941578858638 6.722539899380875 0.92847430769212 1.1131460522670293 0.3318444743600263 0.11062880673311164 0.2170083126382643 21.13465916065003 0.049384245169951435 0.028362507952254746 2.654962682603877e-08 7.575941578858638 0.1846717445749093 LPNS(ph)IASR ddPTM_A459_Selumetinib_30min_R2 2 LPNSIASR 8 0 Q9ULT0;Q9ULT0-4;H7C055;G5E9G4 Q9ULT0 TTC7A Tetratricopeptide repeat protein 7A 1 LPNS(0.792)IAS(0.208)R;LPNS(0.934)IAS(0.066)R 89.266 0.029909 12252000.0 50547.0 39984.0 43367.0 40636.0 48047.0 36806.0 33148.0 37961.0 27100.0 38528.0 True False 47737.80009567321 43050.64423117635 40576.814434419495 35101.30669899005 42010.90631437016 41875.69240839793 34689.44768151589 38071.460225218165 32520.757237265774 37415.5965322341 1.2758797004491529 1.1506069185369683 1.0844893091430992 0.9381463868616859 1.122818027989401 1.119204189951145 0.9271387040864205 1.0175291523795171 0.8691764999456484 1.0 15.191352156328835 -1.522878745280472 0.4167307286372776 0.9768258290166272 6.31957917552355 0.5963107983178145 0.07417186286250572 57.498849412639345 0.7412225225081688 0.052921624843505315 255.47635329806144 0.029999999999990715 1.522878745280472 5.342753346506923 LPNTYPNSS(ph)SPGPGGLGGSVHYATMAR ddPTM_A459_Selumetinib_30min_R2 1 LPNTYPNSSSPGPGGLGGSVHYATMAR 27 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 LPNT(0.002)Y(0.006)PNS(0.114)S(0.563)S(0.315)PGPGGLGGSVHYATMAR 99.907 8.8212e-07 15310000.0 14187.0 9661.1 19042.0 25949.0 30674.0 21114.0 14590.0 19349.0 24578.0 25333.0 True False 13398.54333506074 10402.075304667307 17816.858451361997 22414.701435478222 26820.457890960733 24022.261846191228 15268.463909536531 19405.302386600622 29494.28676669811 24601.57046696135 0.5446214644326994 0.4228215966389935 0.7242163046171839 0.9111085597393068 1.0901929178455998 0.9764523723577686 0.6206296435441508 0.7887830743431989 1.1988782100844915 1.0 14.586462793999276 -5.517642659169004 2.8746398467557874 0.9263516567843669 0.485074941422051 0.5906539879033645 0.15202643288774437 0.19638729580803146 3.2592837713337395 0.045261885867059586 0.09930382516320406 3.0363885204050983e-06 5.517642659169004 -0.44127671536231594 LPNTYPNSSS(ph)PGPGGLGGSVHYATMAR ddPTM_A459_Selumetinib_30min_R1 3 LPNTYPNSSSPGPGGLGGSVHYATMAR 27 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 LPNTY(0.003)PNS(0.086)S(0.247)S(0.664)PGPGGLGGSVHYATMAR;LPNTYPNS(0.017)S(0.061)S(0.922)PGPGGLGGSVHYATMAR;LPNT(0.002)YPNS(0.076)S(0.225)S(0.696)PGPGGLGGSVHYATMAR 154.84 2.64e-15 83586000.0 3934.4400000000005 4644.07 3736.54 4736.72 6632.93 3995.3 4356.01 3766.7 1169.8700000000001 2284.58 True False 4026.1047969124456 4100.340125430428 3229.1383913450477 3909.5407712465626 6032.9826526389015 3955.1109094421545 4027.43265865623 3666.794880034054 1985.1839460758194 2577.8280966936727 1.561820511645573 1.5906181372953194 1.2526585444106015 1.5166025912515062 2.3403355174756677 1.5342803170292802 1.5623356203704286 1.4224357647187926 0.7700994292916662 1.0 11.331940344980548 -8.10613517303873 3.2110481105553395 0.8858266530909972 1.6243376851582418 0.5402743367191294 0.26722834758537534 0.21263850021169414 3.935733988349362 0.22648732659787546 0.07524277608678213 7.831858402514717e-09 8.10613517303873 0.7385110320672447 LPNTYPNSSS(ph)PGPGGLGGSVHYATMAR ddPTM_A459_Selumetinib_30min_R2 1 LPNTYPNSSSPGPGGLGGSVHYATMAR 27 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 LPNTYPNSS(0.014)S(0.986)PGPGGLGGSVHYATMAR 176.2 3.8596e-26 20484000.0 20861.0 12813.0 29468.0 43270.0 49011.0 23761.0 20026.0 26191.0 34519.0 32194.0 True False 19701.629133199553 13795.715899711447 27572.06096233251 37376.55135508658 42853.80001610082 27033.86206911763 20957.2486807662 26267.211473846524 41423.76454144564 31264.475569942522 0.6301602305506311 0.44125850980128273 0.8818974398163302 1.195495867873126 1.3706866734492806 0.8646830492531217 0.6703214526622149 0.8401615889920656 1.324946725838261 1.0 14.932236697246642 -5.41049476781027 4.393917143607668 1.0238641405222253 0.5409831558260856 0.46695170709532885 0.21107205459786932 0.21424801882946135 6.698983074741727 0.06170339838740276 0.13442759496610593 3.8860217963507365e-06 5.41049476781027 -0.4828809846961397 LPPKVES(ph)LESLYFTPIPAR ddPTM_A459_Selumetinib_30min_R1 1 LPPKVESLESLYFTPIPAR 19 1 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 LPPKVES(0.985)LES(0.014)LYFTPIPAR 88.09 0.001766 23658000.0 1346.8 1488.0 1636.9 1935.9 1182.7 1110.9 1579.8 1462.0 835.6 1514.2 True False 1378.1778195833915 1313.784268247567 1414.6179708480872 1597.8314063436767 1075.724993822645 1099.7253546164973 1460.634414095723 1423.2230107547155 1417.9521701906663 1708.5623195570122 0.806630114575346 0.7689413802524913 0.8279580760126225 0.9351905915600168 0.6296082861651507 0.6436553949648315 0.8548909204988375 0.8329944974577935 0.8299095408813101 1.0 10.738567155476467 -8.819026830005908 0.9895981851630185 0.9988119347580202 0.7793054483660464 0.35964055529419214 0.08650413161460406 1.2437366555750664 2.2378088944948655 0.08978451398074169 0.029141925417551635 1.516956649452827e-09 8.819026830005908 -0.2195064863919738 LPPQSCLLLPPT(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 LPPQSCLLLPPTPVR 15 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 LPPQSCLLLPPT(1)PVR 105.53 0.011013 11584000.0 195.68 284.83 293.18 357.51 316.37 183.88 294.28 215.86 227.87 271.07 True False 200.2389632730012 251.48197118612532 253.36776632246432 295.077589793857 287.7543893596602 182.03033414968172 272.08222267381274 210.1346915879022 386.6787470336848 305.86447494539624 0.6546656433662275 0.8222006535117247 0.828366113350353 0.9647331219048405 0.9407904903340961 0.5951339533045747 0.8895515660077412 0.6870189538206947 1.2642159476111625 1.0 8.256748742580138 -8.260067828453845 24.99769056902809 1.132107981106319 0.8062719112322541 0.5154202855247842 0.12944984730901196 95.07144249569201 1732846.4289167703 0.09757208954408265 0.03227122113806967 5.494550528335908e-09 8.260067828453845 -0.325836069874065 LPPQSCLLLPPT(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 LPPQSCLLLPPTPVR 15 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 LPPQS(0.001)CLLLPPT(0.999)PVR;LPPQS(0.015)CLLLPPT(0.985)PVR 132.4 0.0014665 11579400.0 14480.099999999999 12043.5 12584.3 12939.1 13666.1 9679.4 10551.9 7783.6 7793.7 13577.5 True False 13675.354010432999 12967.197724043926 11774.639838749865 11176.772258807512 11949.242341515883 11012.649489155221 11042.58425819318 7806.248987355658 9352.657774172625 13185.482296418411 1.0371523546125918 0.9834450824423936 0.8930003145920741 0.8476574468454197 0.9062423408479847 0.835210213899161 0.8374804963480699 0.5920336330417036 0.7093148027443106 1.0 13.686662722380696 -5.4616790568223115 0.564501446943869 0.7645278757403082 1.0989602181342113 0.3680000292155794 0.10213691336535684 2.073437204213171 0.8511439823540328 0.06501498191606908 0.41486037672822657 3.4539889447410137e-06 5.4616790568223115 0.33443234239390307 LPPQSSGVDTSPCPNS(ph)PVFR ddPTM_A459_Selumetinib_30min_R2 2 LPPQSSGVDTSPCPNSPVFR 20 0 O75815;O75815-3;O75815-2 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 LPPQSSGVDT(0.011)S(0.011)PCPNS(0.979)PVFR;LPPQSSGVDTSPCPNS(1)PVFR 93.115 0.0013012 11670100.0 34734.0 29133.0 34399.0 31301.0 31152.0 21144.1 21434.3 28506.0 18029.8 29109.0 True False 32803.62333121872 31367.40742264058 32185.80579079938 27037.749802763257 27238.407257586503 24056.507847970617 22431.037421259683 28588.947740577663 21636.263794703118 28268.54753573511 1.1604283272690499 1.1096221828513866 1.1385730289153466 0.9564605244957859 0.963558782889486 0.850999076537628 0.7934980526645008 1.0113341587302116 0.765382931944136 1.0 14.786910137609782 -5.929270685859139 1.547899716001901 0.8841998178404588 1.146642816270239 0.6508013362861497 0.07793589686931882 0.22851066006012893 1.1121517581523914 0.02500962919723245 0.046358465994514014 1.1768722272259334e-06 5.929270685859139 0.26244299842978014 LPPTFFCGVCS(ph)DTDEDNGNGEDFQSELQK ddPTM_A459_Selumetinib_30min_R2 1 LPPTFFCGVCSDTDEDNGNGEDFQSELQK 29 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 LPPT(0.003)FFCGVCS(0.498)DT(0.498)DEDNGNGEDFQSELQK 58.26 0.020011 0.0 2188.9 4042.5 3900.3 3630.7 2546.6 3003.7 3241.1 2196.5 1213.7 3277.3 True False 2067.2497008609603 4352.546751313782 3649.3589443255555 3136.1923966931568 2226.673341107144 3417.432410126199 3391.817572117812 2202.8914513498503 1456.4739136114197 3182.675833551986 0.6495319690016409 1.3675746381170637 1.1466323104143261 0.9853948566269936 0.6996230397181521 1.073760756310584 1.0657125480267386 0.6921507456483057 0.4576255923575917 1.0 11.636024505681403 -7.768980990023605 24.067618729072777 0.6811658684442973 1.00914139009942 0.23346841485662795 0.23069128681633505 142.15183886237764 453636.75876923575 0.1218841824697265 0.060440793992751055 1.7022330170581084e-08 7.768980990023605 0.32797552165512267 LPQLVGVSTPLQGGSNSAAAIGQS(ph)SGELR ddPTM_A459_Selumetinib_30min_R2 1 LPQLVGVSTPLQGGSNSAAAIGQSSGELR 29 0 Q86XA6;P15291-2;P15291 Q86XA6 B4GALT1 Beta-1,4-galactosyltransferase 1;Lactose synthase A protein;N-acetyllactosamine synthase;Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase;Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase;Processed beta-1,4-galactosyltransferase 1 1 LPQLVGVS(0.001)T(0.001)PLQGGS(0.047)NS(0.037)AAAIGQS(0.791)S(0.124)GELR 50.224 0.016437 2451800.0 9267.5 7137.2 6933.1 9113.0 8678.5 7926.7 8571.9 8585.8 7269.5 6776.5 True False 8752.449450741911 7684.600290284905 6487.031894188522 7871.793679198159 7588.229243225616 9018.530973581703 8970.510334897614 8610.783256544291 8723.603126800874 6580.844837538532 1.3299887274071691 1.1677224550942635 0.9857445441024711 1.1961676461805908 1.1530782795456216 1.3704214574606124 1.3631244249564924 1.3084616746206446 1.3256053504011513 1.0 12.684057091219469 -6.742967776622633 24.417067324548874 1.2984015446261328 1.158207694232583 0.1358819553145686 0.12651906259198112 282.0409680553683 372820.3320232386 0.040812606821539164 0.040731464698993164 1.8073082180076683e-07 6.742967776622633 -0.1401938503935498 LPQQDHTTTT(ph)DSEMEEPYLQESK ddPTM_A459_Selumetinib_30min_R2 1 LPQQDHTTTTDSEMEEPYLQESK 23 0 B3KPJ4;A0A0A0MSI2;Q8IXK0-3;Q8IXK0-2;Q8IXK0-4;Q8IXK0;Q8IXK0-5 B3KPJ4 PHC2 Polyhomeotic-like protein 2 1 LPQQDHTT(0.008)T(0.036)T(0.955)DSEMEEPYLQESK 168.79 3.6923e-12 10535000.0 35625.0 25156.0 31300.0 35482.0 36901.0 30919.0 35244.0 34675.0 39011.0 26424.0 True False 33645.10511817433 27085.384310711073 29286.192076863288 30649.29039013594 32265.16648087442 35177.811595263156 36882.91583466111 34775.89850924475 46814.29005841237 25661.070462202926 1.3111341230963598 1.0555048492854602 1.1412693059706893 1.1943886142739186 1.2573585551857198 1.3708629827846723 1.4373101032159676 1.3552006164539148 1.8243311450068598 1.0 14.647293733854658 -6.676424179104064 1.5790464162147324 1.4364820453298657 1.160261549495245 0.21951668637499144 0.19548769507807348 0.49728505614264495 2.568781250016009 0.07860132195797098 0.07647933121750222 2.1065696403798504e-07 6.676424179104064 -0.2762204958346206 LPQQDHTTTTDS(ph)EMEEPYLQESK ddPTM_A459_Selumetinib_30min_R2 1 LPQQDHTTTTDSEMEEPYLQESK 23 0 B3KPJ4;A0A0A0MSI2;Q8IXK0-3;Q8IXK0-2;Q8IXK0-4;Q8IXK0;Q8IXK0-5 B3KPJ4 PHC2 Polyhomeotic-like protein 2 1 LPQQDHT(0.002)T(0.008)T(0.005)T(0.014)DS(0.965)EMEEPY(0.006)LQESK 91.166 0.00010131 12141000.0 20402.0 12565.0 16711.0 20667.0 21262.0 16708.0 20814.0 19298.0 17571.0 14707.0 True False 19268.138515676976 13528.695097157137 15635.832453561092 17852.118947436433 18590.87747530831 19009.375339877006 21781.892242158556 19354.15398504411 21085.69097476004 14282.370696624972 1.3490854512150547 0.9472303572371263 1.0947645027345463 1.2499408765279436 1.3016660798267523 1.330967788447688 1.5250894060119708 1.3551079436425522 1.476343908350085 1.0 13.801947848299783 -6.111476173456431 1.9267303687377133 1.3659724585502997 1.113983542536214 0.22045779545186517 0.1612547858817511 0.40498714636662925 2.9756307987777895 0.051407096168201806 0.0754360270506437 7.736131200719379e-07 6.111476173456431 -0.2519889160140858 LPQSSSSESSPPS(ph)PQPTK ddPTM_A459_Selumetinib_30min_R2 1 LPQSSSSESSPPSPQPTK 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 LPQSSSSESS(0.008)PPS(0.992)PQPTK 301.34 1.0951999999999993e-173 0.0 14247.0 11784.0 13587.0 13212.0 14706.0 12668.0 14865.0 17510.0 16887.0 13946.0 True False 13455.208775259782 12687.79490846793 12712.827212407072 11412.502808028756 12858.500806691927 14412.902011345572 15556.251954438705 17560.951201063443 20264.871862203217 13543.342743940433 0.9934924508412013 0.9368289017232992 0.9386772123222717 0.8426651398994492 0.9494333156742327 1.0642056605851016 1.1486272073708603 1.2966482155168502 1.4962976456658112 1.0 13.725296245855931 -7.248928168899381 1.6535460086354448 1.2914333179988022 0.9282232805821924 0.5885345652213898 0.12020343922468606 0.24328398768371073 1.2991576528651225 0.06423941225537706 0.03953455051091555 5.637308876380889e-08 7.248928168899381 -0.36321003741660984 LPS(ph)DSER ddPTM_A459_Selumetinib_30min_R1 1 LPSDSER 7 0 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 LPS(0.994)DS(0.006)ER 140.11 0.003069 9386800.0 3555.0 3941.6 2555.9 3154.9 3075.3 2850.3 3724.0 3461.9 1838.9 2974.0 True False 3637.8245831741588 3480.1156395998732 2208.8228185537437 2603.9559398076685 2797.1396579883126 2821.628569865336 3443.095681790401 3370.07916616399 3120.4789920579433 3355.741869213152 1.0840597176287428 1.037062973027745 0.6582219087881347 0.7759702746201511 0.8335383849545558 0.8408359998580421 1.0260311478003319 1.004272467165122 0.9298924391909881 1.0 11.712416029543288 -7.257814005111779 24.795287567906385 0.9904050538658541 0.863357330180144 0.19739446124358506 0.11628068651892576 498.15791545541896 3407104.5462668994 0.050317874357628245 0.03738937955052358 5.523139276017642e-08 7.257814005111779 -0.12704772368571005 LPS(ph)DSER ddPTM_A459_Selumetinib_30min_R2 1 LPSDSER 7 0 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 LPS(0.998)DS(0.002)ER 100.25 0.020692 13505000.0 47605.0 44495.0 47021.0 51968.0 47206.0 43711.0 52250.0 54150.0 41782.0 39308.0 True False 44959.30467791403 47907.62342602519 43995.7200525939 44889.86875019969 41275.560253005526 49731.79348104881 54679.72853141085 54307.56753498492 50139.56748662139 38173.07590555073 1.1777752672892812 1.2550108234547315 1.1525327474644635 1.1759562907968932 1.0812741513188793 1.3027976473286327 1.4324161004657185 1.422666794506022 1.3134798885654015 1.0 15.220267820095415 -6.906168088164868 7.249531587308429 1.3329021836496684 1.1733616653175367 0.18470942742490037 0.12034325859882235 0.28807003152819916 19.12485820877761 0.04074406332070985 0.035924953464066316 1.241171834818787e-07 6.906168088164868 -0.15954051833213168 LPS(ph)GSGAAS(ph)PTGSAVDIR ddPTM_A459_Selumetinib_30min_R1 1 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 LPS(0.992)GS(0.008)GAAS(0.961)PT(0.034)GS(0.005)AVDIR 117.29 0.018603 6188800.0 1090.8 1113.4 987.58 974.04 1081.7 921.41 1063.1 1017.3 537.61 777.26 True False 1116.2135176726779 983.0426103943834 853.4720603886327 803.942198995297 983.8604259896465 912.1414519733424 982.9095110932794 990.3178993438934 912.2849045191533 877.0288921535354 1.2727214891767444 1.1208782506361135 0.9731401873123483 0.9166655810177761 1.1218107348479562 1.0400358074106186 1.1207264890438846 1.1291736317969845 1.040199373910074 1.0 9.776480560244094 -4.851780481723274 3.38074363460525 1.0481878850805466 1.2855139822625647 0.5310994556535265 0.06564370606922867 0.23269007487231586 4.411481396883629 0.01803462018834626 0.12898492638569362 1.4067584038701146e-05 4.851780481723274 0.23732609718201814 LPS(ph)GSGAASPTGSAVDIR ddPTM_A459_Selumetinib_30min_R1 1 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LPS(0.982)GS(0.018)GAASPTGSAVDIR 240.34 4.8576e-25 154020000.0 156.78 63.078 175.93 263.19 167.02 186.3 199.65 128.47 55.137 148.25 True False 160.4326689592249 55.69279843583338 152.03967231431602 217.22880718817743 151.91307048977603 184.42599114686598 184.5902397608628 125.06255827062812 93.56346195285155 167.27933157728637 0.9590704807730646 0.3329329326624085 0.908896938317037 1.298599206129739 0.9081401094646842 1.1025031568927421 1.103485039187752 0.7476270803535985 0.5593247000130639 1.0 7.3861153920368725 -4.401827526170947 23.081764542414618 0.8895818712272194 44.20475633867594 0.006666314683632657 0.26652839721883015 11793.820888475977 2240259.4732139437 0.0684470668698198 103202.42821749175 3.964354416511489e-05 4.401827526170947 43.31517446744872 LPS(ph)GSGAASPTGSAVDIR ddPTM_A459_Selumetinib_30min_R2 4 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LPS(0.982)GS(0.018)GAASPTGSAVDIR;LPS(0.913)GS(0.087)GAASPTGSAVDIR;LPS(0.982)GS(0.018)GAASPTGSAVDIR;LPS(0.997)GS(0.003)GAASPTGSAVDIR 245.67 5.0948999999999996e-26 312193000.0 146407.0 88504.0 108371.0 190524.0 163279.0 68529.6 153306.3 166648.0 138428.0 87222.0 True False 138270.28505365734 95291.97221478663 101398.52784542319 164574.30252776804 142766.43228721965 77968.93035022952 160435.34672067047 167132.91808993858 166117.46800148452 84703.67423002807 1.6324000854810559 1.1250039987167986 1.1970971598003792 1.9429417203418697 1.6854809851519748 0.9204905343124887 1.8940777738280798 1.9731483859372978 1.9611601209926577 1.0 16.37013693090706 LPS(ph)GSPSPK ddPTM_A459_Selumetinib_30min_R2 2 LPSGSPSPK 9 0 A0A075B784;Q9P275;E9PEW0 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 LPS(0.662)GS(0.333)PS(0.005)PK;LPS(0.994)GS(0.006)PSPK 121.61 0.0062081 10436900.0 84570.0 73904.0 80904.0 92026.0 90066.0 90614.0 102662.0 92991.0 89296.0 87224.0 True False 79869.93796053331 79572.1991611857 75698.72472161498 79491.90004629525 78751.10387974407 103095.25598800664 107435.98642089372 93261.58841451128 107157.69513870405 84705.61648483164 0.9429119493491407 0.939396966379848 0.8936683051609744 0.9384489877425068 0.9297034499931436 1.2171005922195024 1.2683454873400566 1.1010083189845123 1.265060093835607 1.0 16.370170011517473 -6.756487282949132 24.999987665108563 1.1827435941283413 0.9279945801919951 0.7178116877803234 0.07550035320956604 59.80468966877922 301915.7291229739 0.023750567083398042 0.023041730929407592 1.7519137331561745e-07 6.756487282949132 -0.2547490139363462 LPS(ph)IVVEPTEGEVESGELR ddPTM_A459_Selumetinib_30min_R1 1 LPSIVVEPTEGEVESGELR 19 0 B5MBX5;B5MCP4;Q53QV2 B5MBX5 LBH Protein LBH 1 LPS(1)IVVEPTEGEVESGELR 189.84 2.7823e-15 4843700.0 144.15 70.31 127.66 124.17 59.36600000000001 0.0 224.74 394.96 218.47 195.02 True False 147.50841453292682 62.07807251376781 110.32447318618532 102.48604045957661 53.996355781918595 0.0 207.78768086078796 384.4843777891124 370.72763358252126 220.0527166556654 0.6703321675584918 0.2821054584429716 0.5013547429128953 0.4657340387210259 0.24537918278196555 0.0 0.9442631930144741 1.7472375875765567 1.6847219121708428 1.0 7.781705372375002 -7.528348889354289 4.410617758915122 1.523146991296763 0.36598995914439725 0.798609784394787 0.2520008644187256 0.08067991125038658 3.9357905613176025 0.11887724924925316 0.07023718106635908 2.9624505563043453e-08 7.528348889354289 -1.1571570321523659 LPS(ph)IVVEPTEGEVESGELR ddPTM_A459_Selumetinib_30min_R2 6 LPSIVVEPTEGEVESGELR 19 0 B5MBX5;B5MCP4;Q53QV2 B5MBX5 LBH Protein LBH 1 LPS(1)IVVEPTEGEVESGELR;LPS(1)IVVEPTEGEVESGELR;LPS(1)IVVEPTEGEVESGELR;LPS(1)IVVEPTEGEVESGELR;LPS(1)IVVEPTEGEVESGELR;LPS(1)IVVEPTEGEVESGELR 176.85 5.179099999999999e-10 4012500.0 9032.86 13130.320000000002 12072.039999999999 11943.84 9990.309999999998 6818.92 7045.15 6940.52 9135.909999999998 14352.859999999999 True False 8530.849802603561 14137.373323366834 11295.338089443347 10317.068387726771 8735.237943295424 7758.164334007307 7372.763434699883 6960.715764135065 10963.34727865346 13938.455638591196 0.6120369446801784 1.0142711423656503 0.8103722809986288 0.7401873389159453 0.6267005592147741 0.5566014295391085 0.5289512429402166 0.4993893114573636 0.7865539456393865 1.0 13.766783101015953 -6.017285609889608 2.670614039340413 0.629247147569014 0.8318973284057565 0.10853345883384657 0.1662836859144383 0.4145901993207231 5.939877820736915 0.04920531925986578 0.07307069998631956 9.60980090551049e-07 6.017285609889608 0.20265018083674247 LPS(ph)LGNKEPPGQEK ddPTM_A459_Selumetinib_30min_R2 1 LPSLGNKEPPGQEK 14 1 Q9UPY5 Q9UPY5 SLC7A11 Cystine/glutamate transporter 1 LPS(1)LGNKEPPGQEK 62.528 0.044914 16271000.0 99256.0 25399.0 46275.0 52552.0 24590.0 26992.0 96915.0 55875.0 31663.0 37098.0 True False 93739.74887324931 27347.021629342926 43297.716880410495 45394.32694274349 21500.78436261082 30709.902991019884 101421.73953342933 56037.58699939581 37996.48473813825 36026.8843478203 2.6019388179183682 0.7590726238028818 1.2018168560565547 1.2600125646305005 0.5967983285768552 0.8524162870852833 2.8151682103358335 1.5554380572680913 1.054670294863761 1.0 15.1367862705507 LPS(ph)PAPAR ddPTM_A459_Selumetinib_30min_R2 1 LPSPAPAR 8 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 1 LPS(1)PAPAR 106.88 0.013539 53311000.0 27985.0 19232.0 24537.0 18059.0 22704.0 18199.0 19908.0 24796.0 11428.0 24128.0 True False 26429.705732831095 20707.032559373343 22958.31613386562 15599.333046487387 19851.720543664745 20705.7470559266 20833.76144695363 24868.152254801225 13713.919324999008 23431.36194792733 1.1279628470409502 0.8837314965041982 0.9798114247429158 0.6657458956570494 0.8472286240886127 0.883676633989181 0.8891400121449844 1.0613191119691183 0.5852805037742205 1.0 14.516153192837796 -4.1601368269570935 1.4535869971901125 0.8592453160409355 2.0338968130008754 0.24630785040354286 0.13757956305953964 8.871423217688816 4.745146073129097 0.037164581280902186 23.61256481803738 6.91613039952002e-05 4.1601368269570935 1.17465149695994 LPS(ph)PDVR ddPTM_A459_Selumetinib_30min_R2 1 LPSPDVR 7 0 Q9H425-2;Q9H425-3;Q9H425;E5RFY9 Q9H425-2 C1orf198 Uncharacterized protein C1orf198 1 LPS(1)PDVR 88.177 0.03262 3623700.0 12577.0 11959.0 12422.0 14081.0 13366.0 12045.0 15859.0 13722.0 14432.0 12630.0 True False 11878.020689720099 12876.216845754247 11622.782044050975 12163.143508920142 11686.843586443922 13704.089416376499 16596.474924012342 13761.928748200618 17318.803263771937 12265.339083319064 0.9684217133364278 1.0498052078532407 0.9476119628733322 0.9916679372902206 0.9528349364868437 1.1173021245710315 1.3531199432214351 1.1220177978541928 1.4120117793828966 1.0 13.582299498244048 -6.970222796696679 4.5144889009278755 1.2333868793697313 0.9861365842352664 0.5136188187831412 0.10981213674938911 0.14818218024789562 7.170656433969533 0.037384549778680706 0.03177600424334795 1.0709697478599253e-07 6.970222796696679 -0.24725029513446495 LPS(ph)PGLHGQR ddPTM_A459_Selumetinib_30min_R1 3 LPSPGLHGQR 10 0 P10070;P10070-3;P10070-1;P10070-4;P10070-2 P10070;P10070-4 GLI2 Zinc finger protein GLI2 1 LPS(1)PGLHGQR;LPS(1)PGLHGQR;LPS(1)PGLHGQR 112.84 0.0052852 11197000.0 2861.22 3173.41 2974.2 3914.3 3442.7799999999997 2830.37 3440.98 2694.25 1759.6799999999998 2625.63 True False 2927.8808590350404 2801.8656819217144 2570.319976111172 3230.7409855111614 3131.381156872175 2801.8990475703417 3181.4241082511085 2622.789737842609 2986.0484380578164 2962.6551863019936 0.9882624453133344 0.945727904778221 0.8675731107673933 1.090488356677037 1.0569509308239093 0.9457391668544767 1.0738421814865955 0.8852834950112414 1.007896042666046 1.0 11.53267501019856 -5.752898149798113 24.99999862611091 1.0059340154895071 0.9350418591794589 0.22562796517647354 0.06330986541308109 308.40268910064174 902679.2261065907 0.017490469942051484 0.029687070378817366 1.7664520382489479e-06 5.752898149798113 -0.0708921563100482 LPS(ph)PGLHGQR ddPTM_A459_Selumetinib_30min_R2 2 LPSPGLHGQR 10 0 P10070;P10070-3;P10070-1;P10070-4;P10070-2 P10070;P10070-4 GLI2 Zinc finger protein GLI2 1 LPS(1)PGLHGQR;LPS(1)PGLHGQR 103.14 0.009621 22162000.0 35126.0 42190.0 38872.0 42735.0 44043.0 33031.0 32862.0 32586.0 34856.0 34497.0 True False 33173.83754051903 45425.83733776833 36371.01784063353 36914.419278013054 38509.9245905843 37580.720424436025 34390.14811481767 32680.819865097303 41828.17395801239 33500.98197602989 0.990234780707475 1.3559553976737377 1.0856702011498398 1.1018906641132338 1.149516292332515 1.121779667572885 1.0265414947963012 0.9755182665535171 1.2485656088511268 1.0 15.031915763811963 -7.088047903664963 5.13275092792016 1.0610852375978734 1.14343105195657 0.09137943851529629 0.11007491806835977 0.5246552084539704 22.79969271497032 0.04108720423225774 0.03187903353164605 8.164923054409292e-08 7.088047903664963 0.08234581435869659 LPS(ph)PTPENK ddPTM_A459_Selumetinib_30min_R2 3 LPSPTPENK 9 0 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 LPS(0.991)PT(0.009)PENK;LPS(0.997)PT(0.003)PENK;LPS(0.993)PT(0.007)PENK 120.63 0.0065183 38908800.0 288460.0 221030.0 277349.0 272084.0 268153.0 242614.0 316913.0 334699.0 278052.0 273870.0 True False 272428.5479968721 237982.29027653323 259504.66729475837 235025.68982892047 234465.22282176427 276031.8762693873 331650.082451196 335672.9186775975 333670.1694220006 265962.6615002848 1.0243112565505004 0.8947958669614923 0.9757184178820548 0.8836792672443188 0.8815719526160374 1.03785950521138 1.2469798601817679 1.2621054278223864 1.254575238267584 1.0 18.020864194413406 -7.072528912216502 3.6193268914654917 1.2114206989006178 0.9306813291034066 0.6830571149865212 0.08244050936765496 0.12516405007641376 3.1627517890093606 0.03150213210402099 0.024534672773244632 8.461962332467179e-08 7.072528912216502 -0.28073936979721115 LPS(ph)PTSPFSSLSQDQAATSK ddPTM_A459_Selumetinib_30min_R2 2 LPSPTSPFSSLSQDQAATSK 20 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;H0YDG6;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 LPS(0.876)PT(0.062)S(0.062)PFSSLSQDQAATSK;LPS(0.936)PT(0.06)S(0.004)PFSSLSQDQAATSK 233.38 2.8367e-24 39029000.0 89324.0 69439.0 82209.0 103016.0 106084.0 87374.0 100471.0 106958.0 97474.0 77163.0 True False 84359.72967230323 74764.74801842388 76919.76244239138 88985.04308748772 92756.77951700722 99408.97539779823 105143.10057950951 107269.23007214993 116971.52365111612 74935.10369644874 1.1257705068913 0.9977266238435467 1.0264850336897138 1.1874947614398887 1.2378281331637506 1.3266008918929317 1.4031221069023803 1.431495050793311 1.5609709986517244 1.0 16.193354093757364 -6.3202330990724676 1.3013778406057472 1.3816882426532444 1.0432383268679297 0.4397952125880581 0.1401146741647845 0.35544384651316047 1.2268357396950775 0.054163457140887716 0.07304174236730641 4.783732659075077e-07 6.3202330990724676 -0.3384499157853147 LPS(ph)SPASPSPK ddPTM_A459_Selumetinib_30min_R2 1 LPSSPASPSPK 11 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 LPS(0.5)S(0.5)PASPSPK 178.95 5.6168e-05 17681000.0 160640.0 90396.0 111870.0 114090.0 116710.0 95147.0 145560.0 124250.0 92988.0 76650.0 True False 151712.2718928709 97329.08253104775 104672.40599484651 98550.7451837726 102047.8463993618 108252.63559152956 152328.82842166818 124611.5469293051 111588.19830180313 74436.91533938283 2.038132171398611 1.307537826994736 1.4061894628170708 1.3239498807069952 1.3709306186868637 1.4542869636385325 2.046415111737906 1.6740557606553055 1.4990975619158204 1.0 16.183730651002634 -4.749791944765286 24.821064686419557 1.4851005496912648 2.038133518498043 0.31018240734031055 0.2576831306902224 671.1303727694494 1430102.530712548 0.06692016894722147 1.0470749259874368 1.7791315253475705e-05 4.749791944765286 0.5530329688067781 LPS(ph)SPLGCR ddPTM_A459_Selumetinib_30min_R1 1 LPSSPLGCR 9 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 LPS(0.639)S(0.361)PLGCR 123.11 0.005730600000000001 31253000.0 3417.5 4133.9 4192.8 4384.2 4006.1 2922.2 3596.1 3338.7 2099.1 3036.3 True False 3497.1211007025845 3649.9010662020287 3623.440789401833 3618.581771626607 3643.748962334402 2892.805321145313 3324.8432817632784 3250.146830373988 3562.019387801851 3426.03868106654 1.0207476990930868 1.0653414645820052 1.057618178518008 1.0561999173051155 1.063545774445281 0.8443586282700027 0.9704628555823079 0.9486602846416795 1.0396903594483 1.0 11.742325724661887 LPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 2 LPSSPVYEDAASFK 14 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 LPS(0.664)S(0.336)PVYEDAASFK;LPS(0.5)S(0.5)PVYEDAASFK 244.71 4.0624e-20 1057160000.0 9168.1 12326.3 7491.8 7370.299999999999 7992.4 7682.200000000001 10412.1 9609.9 4532.9 8211.2 True False 9381.698891982844 10883.131065658597 6474.454709511692 6083.21546266584 7269.488831172825 7604.924042879516 9626.706914170192 9355.014234645512 7692.000230082895 9265.187503861136 1.0125751786537676 1.1746261002406273 0.6987937056658113 0.6565669027346447 0.7846024517197702 0.8208062750710949 1.0390191143091705 1.0096950796459265 0.8302044860805421 1.0 13.177604457693189 -10.357492866739825 14.43411422261005 0.9999999972816469 0.8901405150486797 0.041384792943813364 0.15591295883001052 0.0 0.0 0.1666200448745866 0.04041129672723972 4.3904307683727736e-11 10.357492866739825 -0.10985948223296715 LPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 2 LPSSPVYEDAASFK 14 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 LPS(0.757)S(0.243)PVYEDAASFK;LPS(0.779)S(0.221)PVYEDAASFK 241.41 1.2543e-19 1012584000.0 417620.0 339860.0 391390.0 406640.0 430070.0 367100.0 391630.0 426250.0 409230.0 355460.0 True False 394410.35226531845 365926.1691778606 366208.3935132107 351254.93050687405 376040.7617254177 417664.6927979918 409841.5710001233 427490.31693051325 491087.4348415593 345196.9462040052 1.1425661686828161 1.0600504239733477 1.0608679988054937 1.017549356590451 1.089351356843071 1.2099315981525498 1.1872688200373425 1.2383954192858766 1.4226297197639037 1.0 18.397060176161602 -6.762277579399819 3.376693977882507 1.228365518540819 1.0667447118902427 0.31740655520625527 0.09997401673568722 0.2617277384228582 6.25855807335164 0.035109155649666254 0.03270153344359765 1.7287111000145916e-07 6.762277579399819 -0.16162080665057643 LPS(ph)TSGSEGVPFR ddPTM_A459_Selumetinib_30min_R1 2 LPSTSGSEGVPFR 13 0 P29317 P29317 EPHA2 Ephrin type-A receptor 2 1 LPS(0.968)T(0.03)S(0.002)GS(0.001)EGVPFR;LPS(0.957)T(0.032)S(0.01)GS(0.001)EGVPFR 98.0 0.012913 13264500.0 1342.47 1096.35 1343.5900000000001 1105.88 1096.05 1153.15 1116.18 1484.22 801.71 1313.06 True False 1373.7469390081044 967.9888323207123 1161.1378578115832 912.7588179386051 996.9124710233442 1141.5503579764281 1031.985643958327 1444.8536641739845 1360.4433154183332 1481.6040412874981 0.9272024783452486 0.653338412521837 0.7837032199254578 0.616061236675237 0.6728602536457972 0.7704827512379306 0.6965326870069432 0.9751955474678795 0.9182232752524908 1.0 10.53294422353586 -7.763450308478743 24.99991454421884 0.9600321229330903 0.7252687950040319 0.6173127959967772 0.08395483802509968 33.98541159249739 422484.9631440501 0.0417527691404719 0.02163349138007774 1.7240493436681843e-08 7.763450308478743 -0.2347633279290584 LPSANQGS(ph)PFK ddPTM_A459_Selumetinib_30min_R1 2 LPSANQGSPFK 11 0 E5RFE4;Q56NI9;E5RFP7;E5RIE3 E5RFE4 ESCO2 N-acetyltransferase ESCO2 1 LPSANQGS(1)PFK;LPS(0.013)ANQGS(0.987)PFK 147.7 0.00066196 108065000.0 5200.0 7127.6 5019.8 5473.9 5252.9 5209.9 5494.7 5475.9 3326.6000000000004 5596.200000000001 True False 5321.1498825613535 6293.097278468656 4338.138731787661 4517.9861228289965 4777.776122474821 5157.493136210719 5080.230355191653 5330.661343770007 5644.997234749009 6314.526781604112 0.8426838726954602 0.9966063168505539 0.6870093170601171 0.715490848180593 0.7566324900852028 0.8167663729348431 0.8045306530319435 0.8441901551989033 0.893969956892792 1.0 12.624458905386883 -8.517177367512243 1.2242122082435092 0.9990737412701851 0.8001071134374079 0.37648806703976556 0.07917660612767798 0.5774649529598038 1.898852231631007 0.081500581053839 0.025360118238906864 3.0396433702734795e-09 8.517177367512243 -0.1989666278327772 LPSANQGS(ph)PFK ddPTM_A459_Selumetinib_30min_R2 4 LPSANQGSPFK 11 0 E5RFE4;Q56NI9;E5RFP7;E5RIE3 E5RFE4 ESCO2 N-acetyltransferase ESCO2 1 LPSANQGS(1)PFK;LPS(0.001)ANQGS(0.999)PFK;LPSANQGS(1)PFK;LPSANQGS(1)PFK 162.67 0.00062825 113173400.0 157432.0 121503.0 141523.0 140926.0 137927.0 113499.0 123110.0 139454.0 106508.0 121024.0 True False 148682.5596902294 130821.88940627781 132417.56425859156 121731.63568909011 120599.37717697523 129132.45700866055 128834.85893783705 139859.7880521476 127812.57608216601 117529.72266188504 1.265063477755038 1.1130962146710095 1.1266729918144753 1.0357519181704642 1.0261181124703334 1.098721702765817 1.0961895937462147 1.1899950487801518 1.087491514379415 1.0 16.842666127518896 -4.436498684073409 1.6429787646730374 1.0861087814947215 1.5149660058946537 0.5304927942830625 0.051200109182106615 2.3816298751862637 2.994869623883122 0.01477868899052162 2.1437918409804277 3.6601704960009046e-05 4.436498684073409 0.42885722439993224 LPSAQT(ph)PNGTDYVASGK ddPTM_A459_Selumetinib_30min_R2 1 LPSAQTPNGTDYVASGK 17 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8;A0A2R8Y7F4;A0A2R8YET2 E7EPN9 PRRC2C Protein PRRC2C 1 LPSAQT(0.928)PNGT(0.072)DYVASGK 208.4 1.0977e-08 4805900.0 20359.0 18855.0 21363.0 25285.0 22369.0 15654.0 16000.0 16800.0 15560.0 18515.0 True False 19227.528283534346 20301.117871619386 19988.52783827572 21841.13938094211 19558.806238602734 17810.196407136365 16744.03170339853 16848.88521861028 18672.434782725297 17980.42384225276 1.0693590124583703 1.1290678156269685 1.1116827953356725 1.2147177159204074 1.087783380981314 0.9905326238908578 0.9312367633988253 0.9370683008604369 1.0384869092377211 1.0 14.134139408628124 -6.710822733560984 3.5080424280617613 0.9705408049972494 1.1315746752149085 0.7265170502209759 0.04437677920112987 0.11919595171381588 2.9986150788647796 0.015847629507809356 0.015243978631542534 1.9461542833832568e-07 6.710822733560984 0.16103387021765914 LPSGS(ph)GAAS(ph)PTGSAVDIR ddPTM_A459_Selumetinib_30min_R1 2 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 LPS(0.069)GS(0.931)GAAS(0.985)PT(0.014)GS(0.001)AVDIR;LPS(0.003)GS(0.997)GAAS(0.985)PT(0.014)GSAVDIR 205.98 3.7784e-10 56169000.0 4556.200000000001 5232.4 5906.0 6063.200000000001 5429.200000000001 4805.6 4939.1 4981.1 2824.3 3768.8 True False 4662.350595178087 4619.788175523235 5103.997639335819 5004.375940360031 4938.129818603114 4757.260027135688 4566.539710507777 4848.985047106919 4792.630821289492 4252.562191220753 1.0963627068884085 1.0863540538126883 1.2002170479417844 1.1767907711476546 1.1612128398257613 1.1186808830113908 1.0738325520400895 1.140250237167009 1.126998408438021 1.0 12.054116619271428 -6.980292502709049 5.767348051575541 1.0967349904821988 1.1456053112093603 0.2390600395239263 0.04778221526595519 0.3051659811244622 33.14338089046956 0.01795915556930674 0.015365931136183493 1.0464235314582878e-07 6.980292502709049 0.048870320727161465 LPSGS(ph)GAAS(ph)PTGSAVDIR ddPTM_A459_Selumetinib_30min_R2 4 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 LPS(0.034)GS(0.963)GAAS(0.926)PT(0.074)GS(0.003)AVDIR;LPS(0.389)GS(0.611)GAAS(0.964)PT(0.036)GSAVDIR;LPS(0.034)GS(0.965)GAAS(0.955)PT(0.045)GS(0.001)AVDIR;LPS(0.025)GS(0.975)GAAS(0.992)PT(0.008)GSAVDIR 213.64 8.703600000000001e-11 39676500.0 130867.5 119575.0 124848.0 153272.0 144420.0 114636.0 145371.5 120318.0 107629.5 137015.0 True False 123594.40825411023 128746.01800577533 116815.41560422472 132396.0891910523 126276.66846881881 130426.06843800208 152131.5627981624 120668.1054602829 129158.40741949451 133059.0209422775 0.9288690641104812 0.9675857908320759 0.8779218032492555 0.99501776169304 0.9490274885127784 0.9802121458159712 1.1433389613182166 0.9068765470071366 0.9706850877515841 1.0 17.02170679785602 -6.340959650446867 1.5645013598620372 1.0007655130899968 0.933676131012337 0.17617929074799055 0.061719422839829195 0.7200164915494558 3.5199850449340784 0.02380133090410068 0.03032242393547323 4.5607928752487455e-07 6.340959650446867 -0.0670893820776598 LPSGSGAAS(ph)PTGSAVDIR ddPTM_A459_Selumetinib_30min_R1 3 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LPSGSGAAS(0.971)PT(0.029)GSAVDIR;LPSGSGAAS(0.944)PT(0.056)GSAVDIR;LPSGSGAAS(0.915)PT(0.085)GSAVDIR 269.85 5.6464e-54 2571920000.0 1897.23 1565.94 1850.68 1918.44 1878.5099999999998 1315.84 1666.52 1471.39 898.31 1144.94 True False 1941.431767633055 1382.5990168142446 1599.36782105757 1583.4204675788853 1708.599102177878 1302.6038442871288 1540.8130546770499 1432.363957451698 1524.3664600334826 1291.904201660022 1.502767593091212 1.0702024306737954 1.2379925841269617 1.2256485160000887 1.3225431885602874 1.008282071235126 1.1926681968347146 1.1087230427853656 1.1799376904841397 1.0 10.335283378754193 -6.752664325620105 24.999634640682924 1.1106390091613203 1.25618369134358 0.3522319424663789 0.11632381497679053 251.50092995086615 716511.3161597142 0.036951292058870135 0.036407083609663965 1.7674033522148663e-07 6.752664325620105 0.1455446821822597 LPSGSGAAS(ph)PTGSAVDIR ddPTM_A459_Selumetinib_30min_R2 5 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LPSGSGAAS(0.758)PT(0.238)GS(0.004)AVDIR;LPSGSGAAS(0.99)PT(0.01)GSAVDIR;LPSGSGAAS(0.991)PT(0.009)GSAVDIR;LPSGSGAAS(0.792)PT(0.208)GSAVDIR;LPSGSGAAS(0.986)PT(0.014)GSAVDIR 274.68 1.6575e-54 1431595000.0 317175.0 272535.2 233295.4 274810.0 288034.6 216900.0 289776.0 228017.4 218968.7 257493.6 True False 299547.6832521243 293437.77350121224 218285.427956826 237380.40392630812 251849.11848600506 246776.00617783816 303251.1581802511 228680.89288368737 262768.558496667 250059.09071928152 1.1979075921234916 1.1734737283781775 0.8729353823087963 0.9492972370790287 1.0071584190823641 0.9868707650979625 1.21271799120746 0.9145074159307669 1.0508258577635685 1.0 17.931909528581386 -5.133921091441388 7.667575711289137 1.0020954492985026 1.1912990619471735 0.4288066580948128 0.08616091577950419 0.24560510499644234 13.995057592190337 0.022265356946586625 0.059769547644061775 7.34647336802889e-06 5.133921091441388 0.18920361264867092 LPSGSGAASPT(ph)GSAVDIR ddPTM_A459_Selumetinib_30min_R1 1 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LPSGSGAAS(0.259)PT(0.741)GSAVDIR 276.3 7.307399999999996e-55 272960000.0 433.82 507.35 503.61 477.48 702.18 493.19 407.66 473.17 276.02 279.98 True False 443.9271619332248 447.94922613938405 435.2225281317152 394.0970814096693 638.667942979948 488.2289563806913 376.90987799105125 460.61999452722887 468.3857802968258 315.91816023614575 1.4051967180405 1.417928066574414 1.377643272569043 1.2474657395924487 2.021624659065341 1.5454285882639507 1.1930617654563282 1.458035822261436 1.4826174599988555 1.0 8.303407061109537 -11.22652643222215 8.456722201225428 0.9985596164290608 1.462005711448527 0.29769078955445616 0.2124190938497784 0.006013917490162183 0.00021074776554246325 0.21441780904675092 0.05188314829014708 5.935722208378925e-12 11.22652643222215 0.4634460950194662 LPSGSGAASPT(ph)GSAVDIR ddPTM_A459_Selumetinib_30min_R2 1 LPSGSGAASPTGSAVDIR 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LPSGSGAAS(0.407)PT(0.58)GS(0.013)AVDIR 139.39 0.00076426 566330000.0 28622.0 40384.0 37777.0 48324.0 37532.0 24689.0 33420.0 30791.0 34708.0 25012.0 True False 27031.30382294414 43481.32294497363 35346.468948487665 41742.18783645029 32816.894619662824 28089.685645572376 34974.096220473664 30880.59671227555 41650.56982254691 24289.838571019514 1.1128646962353839 1.790103413731687 1.455195712607985 1.7185041273289225 1.3510544552904948 1.156437724501245 1.439865321385942 1.271338079171903 1.714732261425594 1.0 14.568065281480267 -6.479857552222754 22.53965526715673 1.3314342370375467 1.534054145433714 0.13578454278896934 0.2420662894316982 298.8031262573245 156548.07549612905 0.07112231165727685 0.0806327526799427 3.3123974968464777e-07 6.479857552222754 0.20261990839616728 LPSPEPSMS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 LPSPEPSMSPK 11 0 O43303-2;O43303 O43303-2 CCP110 Centriolar coiled-coil protein of 110 kDa 1 LPS(0.001)PEPS(0.176)MS(0.823)PK;LPSPEPS(0.126)MS(0.874)PK;LPSPEPS(0.081)MS(0.919)PK 101.32 0.01539 17224800.0 79951.0 71799.4 74975.0 70302.0 64513.0 56003.0 56188.0 48759.0 34710.4 61784.0 True False 75507.64348921135 77306.18310854155 70151.19012660766 60726.74632228555 56408.30018646244 63716.904905382515 58800.85333440982 48900.88061751302 41653.44988960847 60000.13538588952 1.2584578851961856 1.2884334778804842 1.169183863926837 1.0121101549475322 0.9401362150880781 1.0619460188812686 0.9800120109101996 0.8150128379379165 0.6942225983610744 1.0 15.872678135609457 -5.69482181563922 0.5378439268536535 0.8503046700191739 1.4011663906263927 0.71578383994393 0.09378749510200478 0.9940059422583206 0.4289500661250273 0.06876058964023139 0.3094796003931776 2.0191946383271507e-06 5.69482181563922 0.5508617206072188 LPSS(ph)PASPSPK ddPTM_A459_Selumetinib_30min_R2 1 LPSSPASPSPK 11 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 LPS(0.013)S(0.978)PAS(0.005)PS(0.003)PK 80.17 0.044293 18534000.0 123680.0 65519.0 98697.0 95323.0 92185.0 78708.0 109130.0 92287.0 85128.0 61903.0 True False 116806.36073026792 70544.09662321045 92346.94247316869 82339.84295865307 80603.89615564364 89549.3125599138 114204.76123699258 92555.53989106481 102155.978675054 60115.69954669045 1.943025891922744 1.173472107205881 1.53615350348614 1.3696895083904272 1.340812745479914 1.4896160775832437 1.8997493516363795 1.539623435957509 1.6993227966300526 1.0 15.875454187463538 -7.017480140936773 24.532863507768866 1.5960768125778013 1.449960231231681 0.0 0.28402756304415994 1897.4183392327475 2662966.19583308 0.10005076085459813 0.07931123689845639 9.605497406162216e-08 7.017480140936773 -0.14611658134612027 LPSS(ph)PLGCR ddPTM_A459_Selumetinib_30min_R1 3 LPSSPLGCR 9 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 LPS(0.305)S(0.695)PLGCR;LPS(0.047)S(0.953)PLGCR;LPS(0.003)S(0.997)PLGCR 164.66 0.00097838 83507000.0 11902.8 12493.599999999999 10778.1 13067.3 11933.5 9285.7 11033.0 10358.7 6117.4 10271.9 True False 12180.112081182939 11030.84350388294 9314.493219865448 10785.341358600515 10854.11703203054 9192.294288741023 10200.77192728074 10083.953626200326 10380.781002781687 11590.398421778937 1.0508794985249084 0.9517225467552034 0.803638743113701 0.9305410363059066 0.9364748852494243 0.7930956257265707 0.8801053730916603 0.8700264873770063 0.8956362520960178 1.0 13.500642539616448 -4.917505134024436 3.7151278382289226 0.8830370988879215 1.0490959797722108 0.4200242532215165 0.05823490401086337 0.21050099051850615 5.2783176691464675 0.014161771924803225 0.07667126995766653 1.2091908883746105e-05 4.917505134024436 0.16605888088428933 LPSS(ph)PLGCR ddPTM_A459_Selumetinib_30min_R2 2 LPSSPLGCR 9 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 LPS(0.032)S(0.968)PLGCR;LPS(0.077)S(0.923)PLGCR 112.83 0.0094646 111869000.0 126368.0 123404.0 136886.0 149675.0 136831.0 102620.0 104184.0 109115.0 98369.0 128221.0 True False 119344.97245118453 132868.6899935995 128078.90379020812 129289.00679622358 119641.06649533956 116754.97350838984 109028.7624366794 109432.50658503943 118045.54865950522 124518.92657183339 0.9584484522707151 1.0670561789411928 1.028589848277571 1.0383080737661063 0.9608263561950974 0.9376484099470243 0.8755999223441915 0.8788423543139782 0.9480128998012702 1.0 16.926005519509708 -6.51563033250229 2.3697343016113397 0.9162809275070133 1.0268113928950884 0.518054680627297 0.04244589941759595 0.2092592727934546 2.358268627122443 0.014740676961040719 0.015900271107807548 3.0504904344673943e-07 6.51563033250229 0.1105304653880751 LPSS(ph)PVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 3 LPSSPVYEDAASFK 14 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 LPSS(1)PVYEDAASFK;LPS(0.272)S(0.728)PVYEDAASFK;LPS(0.004)S(0.996)PVYEDAASFK 209.22 5.735e-07 1448610000.0 13708.8 18743.699999999997 11422.800000000001 12659.5 13497.300000000001 12352.899999999998 17092.899999999998 15258.099999999999 7861.360000000001 14428.5 True False 14028.188367318675 16549.178890290263 9871.646500949062 10448.755973246438 12276.47159814186 12228.6410415358 15803.568791427266 14853.40562270625 13340.153748982886 16280.53852049157 0.8616538297957427 1.016500705395007 0.606346435563177 0.6417942477821029 0.7540580787723961 0.7511201810765762 0.9707030741972101 0.9123411737278191 0.8193926590445546 1.0 13.99086080077481 -7.253033925777457 24.452175848537507 0.918304324871326 0.7687781710680253 0.29901932244281304 0.11500813434456729 678.0208531326513 1972423.5847312645 0.04844810090041604 0.036890270635749046 5.584265704304478e-08 7.253033925777457 -0.1495261538033007 LPSS(ph)PVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 7 LPSSPVYEDAASFK 14 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 LPS(0.015)S(0.974)PVY(0.011)EDAASFK;LPS(0.053)S(0.947)PVYEDAASFK;LPSS(1)PVYEDAASFK;LPS(0.02)S(0.98)PVYEDAASFK;LPS(0.032)S(0.968)PVYEDAASFK;LPS(0.336)S(0.664)PVYEDAASFK;LPS(0.043)S(0.957)PVYEDAASFK 225.31 1.0095e-09 1008692100.0 938751.2 760296.0 878818.6 854672.1 947642.2999999999 817423.5 919636.4 942924.0 879057.2 820290.2999999999 True False 886579.1664228009 818608.2584630455 822276.3680613429 738264.28558839 828591.0022443492 930016.1672932692 962401.3148249562 945667.7527305278 1054893.2029103558 796606.3876688472 1.1129450882477179 1.027619500841041 1.0322241709203652 0.9267616943780893 1.0401510897610302 1.1674726460765978 1.208126534914293 1.1871204742631891 1.3242339243567296 1.0 19.603507522581317 -6.77879936314324 3.9388082328067004 1.194141247208407 1.0207395768316228 0.43230555322548225 0.0851227988366239 0.18713082701964776 6.375579442830515 0.02948166375685589 0.02719225987478333 1.664181296998343e-07 6.77879936314324 -0.17340167037678422 LPSSPASPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 LPSSPASPSPK 11 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 LPS(0.001)S(0.004)PAS(0.353)PS(0.643)PK 82.85 0.039205 6084700.0 36554.0 29231.0 31178.0 28610.0 22187.0 28550.0 37727.0 28513.0 22876.0 24920.0 True False 34522.47501725597 31472.923707520902 29172.041424039708 24713.268644997177 19399.67070570338 32482.503348904007 39481.380254632284 28595.96810941874 27451.839208844707 24200.49485006421 1.426519384464751 1.3005074442697768 1.2054316081045884 1.0211885665193994 0.8016228934943413 1.342224758218852 1.6314286339697526 1.181627412438753 1.1343503254344351 1.0 14.562748927480497 -8.519964329670511 2.6804177649259717 1.0032133632849127 1.233704224654104 0.11158112508804019 0.21137824303534267 0.696650664861058 11.98734407062122 0.2242893764587831 0.060495899228925246 3.0201997712093885e-09 8.519964329670511 0.23049086136919117 LPSSSGLPAADVSPATAEEPLS(ph)PSTPTR ddPTM_A459_Selumetinib_30min_R1 1 LPSSSGLPAADVSPATAEEPLSPSTPTR 28 0 O43149 O43149 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 1 LPSSSGLPAADVSPATAEEPLS(0.853)PS(0.105)T(0.037)PT(0.005)R 174.62 6.1048e-23 9933200.0 2044.4 2973.7 2281.1 2783.7 2496.4 2349.3 2795.0 2400.2 1156.7 2127.2 True False 2092.0305422900833 2625.537821564375 1971.3391491853924 2297.579051520684 2270.601060775216 2325.6681749937306 2584.17089973259 2336.538899051619 1962.835417974561 2400.246840682653 0.8715897493672318 1.0938615883429919 0.8213068405184214 0.9572261538180927 0.9459864803444281 0.9689287516496797 1.0766271434806378 0.9734577541979329 0.8177639835644205 1.0 11.228967064461173 -6.73652003329252 4.680506129013409 0.9726841468902888 0.940805865946917 0.024951987451563018 0.08850307313265739 0.9718169643555333 51.191335335212834 0.030524362574195375 0.02923007419873706 1.834340550043543e-07 6.73652003329252 -0.03187828094337186 LPST(ph)SGSEGVPFR ddPTM_A459_Selumetinib_30min_R2 1 LPSTSGSEGVPFR 13 0 P29317 P29317 EPHA2 Ephrin type-A receptor 2 1 LPS(0.058)T(0.85)S(0.066)GS(0.026)EGVPFR 96.371 0.033297 19308000.0 13113.0 7562.0 9096.4 13522.0 9624.6 6911.7 13840.0 9769.5 7019.2 7501.9 True False 12384.231955498097 8141.981084337624 8511.147527411476 11680.280273248927 8415.471702984303 7863.723936834325 14483.587423439732 9797.92762757221 8423.236132834538 7285.300654722983 1.6998930507376562 1.1175902643165816 1.1682630451076566 1.6032667458516932 1.1551303236234516 1.0793959384142033 1.9880562395252934 1.3448899492185429 1.1561960901879653 1.0 12.830772796296767 -8.4172455010007 3.1751481746442116 1.01019052124319 1.385626837463227 0.1806980552710471 0.27876736755792725 0.42417900802145897 8.035520417478535 0.2684866295134662 0.07183514008846739 3.826083986415551e-09 8.4172455010007 0.3754363162200369 LPSTSDDCPAIGT(ph)PLR ddPTM_A459_Selumetinib_30min_R1 2 LPSTSDDCPAIGTPLR 16 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 LPST(0.001)SDDCPAIGT(0.999)PLR;LPSTSDDCPAIGT(1)PLR 242.1 3.0046e-21 44666000.0 1121.67 1365.81 869.0699999999999 762.72 1086.42 870.3900000000001 1482.91 1397.04 713.72 1282.29 True False 1147.8027286101144 1205.9003302521573 751.0550674597998 629.5252700276096 988.1535028230298 861.6346668508895 1371.0529048023088 1359.985960974533 1211.1307119536648 1446.8844120623178 0.7932926217472293 0.8334462104912213 0.5190843589152245 0.43509022889417637 0.6829526219130141 0.5955103667353482 0.9475897959589443 0.9399409860502098 0.8370611376118005 1.0 10.498733957875714 -7.2640600671610915 24.964007165973094 0.9261430763319421 0.6385773890941043 0.5946514713307081 0.11638771016562867 182.66571503241164 1740012.464669058 0.05195499442886423 0.0368517643667304 5.444273480246066e-08 7.2640600671610915 -0.2875656872378378 LPSTSDDCPAIGT(ph)PLR ddPTM_A459_Selumetinib_30min_R2 4 LPSTSDDCPAIGTPLR 16 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 LPSTSDDCPAIGT(1)PLR;LPSTSDDCPAIGT(1)PLR;LPSTSDDCPAIGT(1)PLR;LPSTSDDCPAIGT(1)PLR 226.22 1.131e-14 71817000.0 54040.0 44807.700000000004 64349.0 67233.0 66759.0 60329.0 79305.0 79738.0 73058.0 62111.0 True False 51036.67313926007 48244.30651053622 60208.855397893785 58075.749416605875 58372.13758696774 68638.77213786445 82992.83963987627 79970.02437866341 87671.64141107607 60317.69404624153 0.8461310390966484 0.799836719115133 0.9981955767694914 0.9628310620111421 0.9677448468473901 1.1379541811602365 1.3759285886534594 1.3258136877274478 1.45349789638616 1.0 15.880293654779985 -6.877188038029703 1.9986312219532751 1.3173926584425086 0.9032970824358244 0.6715170414286551 0.12332432011420161 0.1806832595223789 1.4769548447191352 0.05055601194402228 0.042818733561192965 1.3268198554231763e-07 6.877188038029703 -0.41409557600668423 LPSTSGS(ph)EGVPFR ddPTM_A459_Selumetinib_30min_R2 1 LPSTSGSEGVPFR 13 0 P29317 P29317 EPHA2 Ephrin type-A receptor 2 1 LPS(0.018)T(0.066)S(0.046)GS(0.869)EGVPFR 107.93 0.0064507 4572800.0 7406.9 5463.9 9083.3 6056.0 5574.4 4902.4 5576.0 5255.1 2464.0 6045.9 True False 6995.254150169974 5882.963560792427 8498.890367149268 5231.1623528172995 4874.094036231711 5577.661100443682 5835.295048634387 5270.391470971363 2956.8688499122845 5871.3391578652945 1.1914239600345815 1.0019798554664587 1.4475216196230265 0.8909657936911363 0.8301503124210315 0.9499810776510501 0.9938610071294174 0.8976472537634115 0.5036106364169474 1.0 12.519473881023965 -5.882954308180632 9.738582416651186 0.8677491962304374 1.1919748288083196 0.4767906983477732 0.16628797055520997 0.26648865215801226 21.486679979819744 0.04646452195055239 0.06901828329118567 1.3093196683618312e-06 5.882954308180632 0.3242256325778822 LPVGSQCSVDLES(ph)ASGEK ddPTM_A459_Selumetinib_30min_R2 1 LPVGSQCSVDLESASGEK 18 0 F5H5D6;F5H7V9;E9PC84;J3QSU6;P24821-6;P24821-5;P24821-2;P24821-3;P24821-4;P24821 F5H5D6 TNC Tenascin 1 LPVGSQCSVDLES(0.974)AS(0.026)GEK 185.28 2.3441999999999995e-10 3040700.0 8451.3 8335.2 8185.6 7441.8 6799.3 8163.0 10378.0 7129.2 9555.8 9111.6 True False 7981.610579234427 8974.483038107765 7658.947407807419 6428.21400217896 5945.111147486771 9287.37915366387 10860.597563616875 7149.944791697404 11467.22701136031 8848.524433220113 0.9020272972597531 1.0142349841307736 0.8655621019763869 0.7264729900101135 0.6718759938286405 1.0495963732434483 1.227390809120989 0.8080380910577912 1.2959479400100624 1.0 13.111221178234768 -6.895208859061372 8.740832917628047 1.0768839680289182 0.8418776647132862 0.3914412789084899 0.14999450214171242 0.2974827898767948 22.55320409149498 0.053404702786084654 0.04710826553236984 1.272890780557271e-07 6.895208859061372 -0.235006303315632 LQAALDDEEAGGRPAMEPGNGS(ph)LDLGGDSAGR ddPTM_A459_Selumetinib_30min_R1 9 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 LQAALDDEEAGGRPAMEPGNGS(1)LDLGGDSAGR;LQAALDDEEAGGRPAMEPGNGS(0.998)LDLGGDS(0.002)AGR;LQAALDDEEAGGRPAMEPGNGS(0.996)LDLGGDS(0.004)AGR;LQAALDDEEAGGRPAMEPGNGS(0.998)LDLGGDS(0.002)AGR;LQAALDDEEAGGRPAMEPGNGS(1)LDLGGDSAGR;LQAALDDEEAGGRPAMEPGNGS(0.999)LDLGGDS(0.001)AGR;LQAALDDEEAGGRPAMEPGNGS(1)LDLGGDSAGR;LQAALDDEEAGGRPAMEPGNGS(0.996)LDLGGDS(0.004)AGR;LQAALDDEEAGGRPAMEPGNGS(0.721)LDLGGDS(0.279)AGR 136.96 3.5555e-19 426669000.0 7970.780000000001 10176.640000000001 11196.27 12379.61 10384.859999999999 9369.49 10411.34 9071.16 5879.720000000001 8243.61 True False 8156.483665561998 8985.154257808423 9675.878030708844 10217.743507560439 9445.551246595947 9275.241437416253 9626.004241582077 8830.563369519665 9977.455402242058 9301.757643061272 0.8768755302549083 0.9659630580152749 1.0402203972629465 1.0984744926333847 1.015458756189153 0.9971493338503826 1.0348586375783162 0.9493435228455884 1.0726419441474944 1.0 13.183287635650325 -4.894262014021777 2.7282384143882568 1.0253150343441224 0.8661486563641418 0.580994098103897 0.03920255787020829 0.2553312437110717 3.0722662412230597 0.01040588274058105 0.08280821722755259 1.275668953302765e-05 4.894262014021777 -0.15916637797998057 LQAALDDEEAGGRPAMEPGNGS(ph)LDLGGDSAGR ddPTM_A459_Selumetinib_30min_R2 11 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 LQAALDDEEAGGRPAMEPGNGS(1)LDLGGDSAGR;LQAALDDEEAGGRPAMEPGNGS(0.993)LDLGGDS(0.007)AGR;LQAALDDEEAGGRPAMEPGNGS(0.982)LDLGGDS(0.018)AGR;LQAALDDEEAGGRPAMEPGNGS(0.999)LDLGGDS(0.001)AGR;LQAALDDEEAGGRPAMEPGNGS(0.956)LDLGGDS(0.044)AGR;LQAALDDEEAGGRPAMEPGNGS(0.985)LDLGGDS(0.015)AGR;LQAALDDEEAGGRPAMEPGNGS(1)LDLGGDSAGR;LQAALDDEEAGGRPAMEPGNGS(1)LDLGGDSAGR;LQAALDDEEAGGRPAMEPGNGS(0.999)LDLGGDS(0.001)AGR;LQAALDDEEAGGRPAMEPGNGS(0.938)LDLGGDS(0.062)AGR;LQAALDDEEAGGRPAMEPGNGS(0.965)LDLGGDS(0.035)AGR 116.65 9.535899999999999e-17 227916900.0 328227.8 302251.4 335885.4 351988.4 361340.5 266274.80000000005 286875.5 287030.60000000003 251286.19999999998 296969.7 True False 309986.2128759889 325433.1104885695 314274.89904837246 304046.9727061413 315945.6759649442 302951.7366980297 300215.77918301895 287865.8115255263 301550.4615230637 288395.41314105643 1.074865267445749 1.1284267906487044 1.0897361217553698 1.0542711806495673 1.0955294764359262 1.0504734919270495 1.0409866645007322 0.9981636267728325 1.0456146241673165 1.0 18.13768869348408 -7.00316650032446 0.6381370817984262 1.0067566342234537 1.10144218559609 0.684727680839665 0.021831419136894195 0.43259899099236754 0.37155398862632705 0.017941517145358517 0.015488815223072022 9.927353794085568e-08 7.00316650032446 0.09468555137263635 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR ddPTM_A459_Selumetinib_30min_R1 1 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 171.94 2.4695e-28 5188100.0 498.52 414.04 485.0 583.12 567.49 335.3 473.33 482.64 358.15 528.37 False True 510.13454604893974 365.5640043180261 419.13966391430273 481.28903851806655 516.1606296984972 331.9271864280415 437.62633701983094 469.83881936433363 607.75439175896 596.1914362596347 0.8556556082881772 0.6131654735121473 0.7030286556007693 0.8072726464129729 0.8657632403054429 0.5567459816438741 0.734036603687896 0.788067038184903 1.0193947024329444 1.0 9.219631842268367 -8.183957841944304 3.3658013847774444 1.015622889855197 0.7303027899161353 0.5800094891128889 0.09239498377719656 0.17478847162423036 3.618660256331662 0.07761179002827254 0.024479338957221115 6.5469972432865994e-09 8.183957841944304 -0.2853200999390618 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR ddPTM_A459_Selumetinib_30min_R2 1 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR 32 1 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 98.968 2.0776e-08 6281100.0 17008.0 15781.0 21912.0 23949.0 21832.0 16883.0 18891.0 17222.0 20934.0 22190.0 False True 16062.763448418498 16991.351956087285 20502.20577598173 20687.10488567064 19089.268979443652 19208.480001385167 19769.468931806354 17272.113168744418 25121.384944831054 21549.317043456045 0.7453954766188905 0.7884867962090292 0.951408610056517 0.9599888870702176 0.8858410195064885 0.8913730287901757 0.9174058227432231 0.8015155716496128 1.1657624644981384 1.0 14.395354526653506 -5.183066610466017 4.210504817189865 0.9349794471547899 0.7563306308510089 0.38610872969870347 0.09013362821004757 0.23170648460167528 7.645130359256736 0.022294782598483092 0.06520586732220043 6.560446369092267e-06 5.183066610466017 -0.17864881630378093 LQAEEAERR ddPTM_A459_Selumetinib_30min_R1 1 LQAEEAERR 9 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 99.788 0.022425 0.0 905.95 883.55 1459.2 1821.7 1386.0 1028.3 1194.1 1027.5 711.42 746.72 False True 927.0568723281652 780.1035552487486 1261.0486548118565 1503.5742925441803 1260.636544718175 1017.9562356216968 1104.028075624574 1000.247362209624 1207.2277799390183 842.5687856687438 1.1002744085663743 0.9258633461356907 1.4966714602546862 1.784512218015291 1.496182348741548 1.2081580197796535 1.3103121008076641 1.1871403014481854 1.4327943314216727 1.0 9.718650659680288 -11.061207396351133 7.174233000515071 0.9998389580649328 1.330428394138087 0.15483077756723052 0.22897859224629868 0.0006535464101084073 4.2056562988962644e-05 0.24566608292058295 0.05955417498767638 8.685455582597797e-12 11.061207396351133 0.33058943607315416 LQAVTDDHIR ddPTM_A459_Selumetinib_30min_R1 4 LQAVTDDHIR 10 0 P30043;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 ;;; 163.84 0.00054154 51105400.0 27961.3 30248.3 35756.2 37708.9 33387.2 28784.7 29461.1 29275.5 16984.9 23608.8 False True 28612.74388678131 26706.814973946854 30900.70443474759 31123.748498720543 30367.333654988928 28495.152052416484 27238.82550773231 28499.01863977407 28822.134771985948 26639.21944918608 1.0740834182983365 1.0025374438950703 1.1599703397349999 1.168343109980705 1.139948327424314 1.0696691810648045 1.0225083944253686 1.0698143274856655 1.0819436668166553 1.0 14.701264190438879 -6.960484967200255 7.26248972644513 1.0488832333236957 1.108981545276686 0.2811855655905062 0.04924424723623175 0.3273138387371224 47.672492450161286 0.019300411006142756 0.016909797526296462 1.0952544661779284e-07 6.960484967200255 0.06009831195299031 LQAVTDDHIR ddPTM_A459_Selumetinib_30min_R2 2 LQAVTDDHIR 10 0 P30043;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 ; 206.73 0.00035476 38831000.0 244430.0 221970.0 264900.0 270670.0 286360.0 205915.0 201965.0 214800.0 191787.0 231160.0 False True 230845.55913081684 238994.38525395686 247856.62240131226 233804.27906820652 250384.89670911906 234277.92213973997 211356.7726860554 215425.0324379455 230149.75897651253 224485.81017419146 1.0283302938020469 1.0646302546628998 1.1041081937828767 1.0415102802568426 1.1153707065708562 1.0436201823088518 0.9415150673534844 0.9596376370995781 1.0252307653562873 1.0 17.7762647290321 -7.07546387362498 5.622938249291659 0.9790193967377314 1.07154490278185 0.6353411363521573 0.03192298428409513 0.13840524512306415 7.712888541048649 0.012157885754458506 0.009456220759186193 8.404969201320756e-08 7.07546387362498 0.09252550604411858 LQDEIQNMKEEMAR ddPTM_A459_Selumetinib_30min_R1 2 LQDEIQNMKEEMAR 14 1 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ; 185.66 0.00020736 39613000.0 2175.48 2617.5 3205.0 3331.3 2902.1000000000004 2561.5 2608.0699999999997 2413.91 1376.53 1584.34 False True 2226.164451252805 2311.0418831572633 2769.7786038048243 2749.550991245773 2639.605567407369 2535.7336356559167 2411.3411801307957 2349.8852653152653 2335.8708722266115 1787.7054717784667 1.2452635439092465 1.2927419642890978 1.5493483952081657 1.5380335489550363 1.476532689012472 1.418429196355979 1.3488470098667407 1.3144700301093357 1.3066307113233884 1.0 10.803893353730603 -8.851384419976554 0.7507296954892049 0.998552833284072 1.424579767338826 0.634951144090421 0.0927534969143182 0.8349392117695283 0.8941256101125304 0.10601798194958365 0.037405159560327104 1.4080419046927894e-09 8.851384419976554 0.4260269340547541 LQDGTPQAALS(ph)PLTPAR ddPTM_A459_Selumetinib_30min_R1 2 LQDGTPQAALSPLTPAR 17 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 LQDGTPQAALS(0.985)PLT(0.015)PAR;LQDGT(0.005)PQAALS(0.938)PLT(0.057)PAR 147.06 0.00036751 3322200.0 1744.45 1875.39 2269.3 2325.1000000000004 1962.27 1643.67 2085.73 1719.3400000000001 1241.7 1552.3899999999999 True False 1785.0922908911841 1655.818466954842 1961.1415243726321 1919.0649325325105 1784.7830249669066 1627.136172132953 1928.4017068691428 1673.7375179965888 2107.0742098201904 1751.6543780591137 1.0190893324909909 0.9452883443762115 1.119593881611301 1.095572823366498 1.018912776014924 0.9289139413083701 1.1009030839781706 0.9555181312943373 1.202905228458877 1.0 10.774502427038739 -8.246074047672522 24.998104809077695 1.1014526520810446 1.0253520640379232 0.13897139243315038 0.07795747698702452 1413.0621714957933 2298943.7360055204 0.051549091555937065 0.01931886369895246 5.6744784669676635e-09 8.246074047672522 -0.07610058804312136 LQDGTPQAALS(ph)PLTPAR ddPTM_A459_Selumetinib_30min_R2 2 LQDGTPQAALSPLTPAR 17 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 LQDGTPQAALS(0.777)PLT(0.223)PAR;LQDGTPQAALS(0.982)PLT(0.018)PAR 145.17 0.00048583 13780400.0 43280.0 53026.0 58669.0 63289.0 70361.0 52920.0 46212.0 47684.0 40360.0 62890.0 True False 40874.67086356728 57092.92369453672 54894.300413977384 54668.92902038536 61521.62214467906 60209.24964007008 48360.94956734078 47822.752545488845 48433.12775262165 61074.202292156464 0.6692624599178213 0.9348124339213671 0.8988132198826485 0.8951230956545181 1.007325840301316 0.9858376758168895 0.7918392341172109 0.7830270515318797 0.7930210454642604 1.0 15.898275494707299 -10.390418425753458 15.718445715049942 0.9999999999999987 0.8698224917955755 0.1449151268003408 0.09889822783853945 0.0 0.0 0.10067031627139966 0.024416138079489242 4.0698797185009564e-11 10.390418425753458 -0.1301775082044232 LQEAY(ph)CQYLLSYDS(ph)LS(ph)PEEHRRLEK ddPTM_A459_Selumetinib_30min_R2 1 LQEAYCQYLLSYDSLSPEEHRRLEK 25 2 Q92833-2;Q92833-3;Q92833 Q92833-2 JARID2 Protein Jumonji 3 LQEAY(0.794)CQY(0.202)LLS(0.058)Y(0.051)DS(0.953)LS(0.943)PEEHRRLEK 54.167 0.029677 12587000.0 25777.0 16991.0 24549.0 27456.0 25825.0 15500.0 25012.0 19016.0 17485.0 24965.0 True False 24344.417533506778 18294.15506532406 22969.544066930255 23716.4454357582 22580.632621570716 17634.98430500918 26175.10756033776 19071.333411731735 20982.488571719277 24244.19558314017 1.0041338534010305 0.7545787610312025 0.9474244665351435 0.9782318969679912 0.9313830415257695 0.7273899537946663 1.0796442996252835 0.7866350255396499 0.8654644159986427 1.0 14.565351765786588 LQEDPNYS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 LQEDPNYSPQR 11 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710;P46379-4;H0Y4L1 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 LQEDPNYS(1)PQR;LQEDPNYS(1)PQR 182.37 3.6868e-05 29595000.0 6768.5 10371.5 5108.6 5890.6 6300.7 6024.3 7719.900000000001 7226.6 3077.8999999999996 6095.2 True False 6926.192880791646 9157.19995842046 4414.880179531145 4861.917290256764 5730.8027974789375 5963.701011626754 7137.581727672853 7034.927092694964 5222.971499078329 6877.578292275721 1.0070685619923112 1.3314570288069285 0.6419236527615457 0.7069228562206604 0.8332588236640303 0.8671222279395421 1.0378045039035244 1.0228785182418008 0.7594201442889137 1.0 12.747684942502012 -5.255103019376081 24.96689791372017 0.8598563962022655 1.1692627872436383 0.42104307280230246 0.1456801265117238 491.4369834696948 1936375.486422009 0.039053238309225614 0.09807988329915354 5.5577240637138505e-06 5.255103019376081 0.3094063910413728 LQEDPNYS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 4 LQEDPNYSPQR 11 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710;P46379-4;H0Y4L1 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 LQEDPNYS(1)PQR;LQEDPNYS(1)PQR;LQEDPNYS(1)PQR;LQEDPNYS(1)PQR 150.9 0.00060533 61493900.0 128440.0 115882.0 137562.0 157996.0 176667.0 140783.0 142324.0 167027.0 154791.0 122733.0 True False 121301.8189860578 124769.77678064152 128711.41068618103 136476.67224169782 154472.51203698097 160174.58034916827 148942.3480096557 167513.02091719152 185753.52522190445 119189.37939136983 1.0177233878175636 1.046819585920889 1.0798899309941423 1.1450405475605632 1.296025810569544 1.3438662166636473 1.2496276830219 1.4054358011811299 1.5584738016964148 1.0 16.862896161729807 -6.093388494888433 1.4661147594308463 1.337776518247209 1.0330171367820957 0.44114155334989746 0.1327186588837503 0.3508403384596385 1.5172411868353854 0.046286739582821916 0.07441110980937653 8.065132470564782e-07 6.093388494888433 -0.3047593814651133 LQEDPNYS(ph)PQRFPNAQR ddPTM_A459_Selumetinib_30min_R1 4 LQEDPNYSPQRFPNAQR 17 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710;P46379-4;H0Y4L1 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 LQEDPNY(0.002)S(0.998)PQRFPNAQR;LQEDPNY(0.076)S(0.924)PQRFPNAQR;LQEDPNY(0.152)S(0.848)PQRFPNAQR;LQEDPNY(0.001)S(0.999)PQRFPNAQR 119.51 0.0071336 60868000.0 7057.599999999999 7129.900000000001 8115.9 8448.8 7815.900000000001 6383.1 7176.000000000001 6793.599999999999 3371.34 5242.369999999999 True False 7222.0283483009625 6295.127993399417 7013.805357447603 6973.375683618194 7108.95322500922 6318.891809391087 6634.708542569253 6613.411659277176 5720.917747068696 5915.279254508053 1.2209108036272391 1.0642148447348247 1.1857099311249524 1.1788751441115417 1.201795032684461 1.068232206379004 1.1216222019464122 1.118021884467597 0.9671424629207095 1.0 12.530230563046931 -8.031761964906503 1.1253071544035171 0.9804758247490967 1.1561364798648708 0.5929283135593104 0.052489254226026884 0.34311511925833815 0.8003265750243597 0.04743672445936012 0.01663876009476384 9.294756891550109e-09 8.031761964906503 0.1756606551157741 LQEDPNYS(ph)PQRFPNAQR ddPTM_A459_Selumetinib_30min_R2 3 LQEDPNYSPQRFPNAQR 17 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710;P46379-4;H0Y4L1 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 LQEDPNYS(1)PQRFPNAQR;LQEDPNY(0.053)S(0.947)PQRFPNAQR;LQEDPNY(0.277)S(0.723)PQRFPNAQR 164.58 2.4556e-05 67172000.0 90442.0 96361.0 98140.0 101852.0 118108.0 72390.0 72059.0 73224.0 59213.0 101238.0 True False 85415.59570801193 103751.57885054983 91825.77924675286 87979.58189549982 103270.2171410832 82361.06540900734 75409.88628219963 73437.06971711422 71057.25454945459 98314.9958920866 0.8687951917504687 1.055297596354788 0.9339956576669495 0.8948744908871152 1.0504014794898184 0.8377263779719752 0.7670232358547999 0.7469569525051996 0.7227509283268353 1.0 16.585123865790976 -6.936545035566017 6.4677920173075 0.7899214556586358 0.9603495397945236 0.3903685509589564 0.09031577225860651 0.1843852019991634 14.468262822192795 0.030484777648215423 0.026786811011750757 1.1573240134258947e-07 6.936545035566017 0.17042808413588784 LQEEERER ddPTM_A459_Selumetinib_30min_R1 1 LQEEERER 8 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 120.87 0.020217 3939900.0 1936.8 1731.3 3285.5 3344.2 2498.3 2570.0 1814.8 1769.0 1726.9 1483.4 False True 1981.923671643237 1528.5985911404662 2839.347145959674 2760.198248408763 2272.329206110691 2544.148133373298 1677.9081748961376 1722.0803734781746 2930.4231722142904 1673.8088395396069 1.184080060294328 0.9132456198289156 1.6963389599141183 1.649052259257978 1.3575798815447235 1.5199753241075513 1.0024491060506397 1.028839335053246 1.75075140182694 1.0 10.708919056280353 -7.248986770889942 24.731442594860205 1.1979132231600262 1.3898651269271156 0.09248095928161992 0.2932883857781439 1833.8951842777697 3642205.2642241465 0.11756338445387324 0.09038615532251043 5.636548251395412e-08 7.248986770889942 0.19195190376708937 LQEEERER ddPTM_A459_Selumetinib_30min_R2 1 LQEEERER 8 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 111.74 0.032323000000000005 3401000.0 15970.0 24723.0 20023.0 20578.0 24281.0 10062.0 11260.0 12342.0 9216.8 27360.0 False True 15082.451332975259 26619.174603025516 18734.74197939404 17775.240900969995 21230.603705105856 11447.949166258222 11783.612311266712 12377.913176671907 11060.417538908896 26570.045710182872 0.5676486784211653 1.001849033056944 0.7051076307412606 0.6689954957118384 0.7990427994246658 0.43085921985715053 0.44349236127774844 0.46585968694544316 0.4162739371829545 1.0 14.697513089342394 -6.7561360385729525 24.99745051269155 0.5111754711013422 0.755771307310359 0.194236476788053 0.19208192263873464 168.40499082676894 793781.236582378 0.06056898874718629 0.05887282449230103 1.7533312016650752e-07 6.7561360385729525 0.24459583620901681 LQEEGGGS(ph)DEEETGSPSEDGMQSAR ddPTM_A459_Selumetinib_30min_R2 2 LQEEGGGSDEEETGSPSEDGMQSAR 25 0 Q13610-2;Q13610 Q13610-2 PWP1 Periodic tryptophan protein 1 homolog 1 LQEEGGGS(1)DEEETGSPSEDGMQSAR;LQEEGGGS(1)DEEETGSPSEDGMQSAR 137.23 2.4127e-08 23690000.0 46580.0 42981.0 53834.0 58451.0 58533.0 46102.0 46203.0 39667.0 46328.0 47627.0 True False 43991.27007451394 46277.504494302455 50370.37905002741 50489.8729664009 51179.561248340746 52452.13202771183 48351.53104950767 39782.42440277463 55594.8945124741 46251.88476019296 0.9511238364144539 1.0005539176239482 1.0890448964661235 1.0916284434284373 1.1065400148274354 1.1340539374701366 1.0453959076522172 0.8601254761625127 1.2020027897397658 1.0 15.497224536070954 -5.033967688700369 3.5404991974109072 1.0649188970880379 0.956142636134543 0.1612796401915103 0.08560849990677395 0.4277799843279661 10.860311941699884 0.022175517318040627 0.08777603863861186 9.247669735949084e-06 5.033967688700369 -0.10877626095349491 LQEEMLQR ddPTM_A459_Selumetinib_30min_R2 1 LQEEMLQR 8 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 154.12 0.01057 5314500.0 30398.0 23478.0 25744.0 30043.0 28805.0 20800.0 18549.0 21776.0 21723.0 21294.0 False True 28708.600852835447 25278.687106331483 24087.659067947865 25951.091572934278 25186.2583800327 23665.01119639941 19411.5652541462 21839.364554789125 26068.206991333012 20679.18689154364 1.3882848007227637 1.222421715075689 1.1648262184717744 1.2549377163154556 1.2179520651429552 1.1443878968992136 0.9387006053939283 1.0561036403089872 1.2606011603866838 1.0 14.335891839351234 -6.8721625500110575 3.252878919608426 1.0659097191307425 1.2452957947701448 0.4663333641357491 0.09352575015260137 0.24089916577083723 5.04641795767464 0.03576013887278116 0.03134984704312961 1.342262478084283e-07 6.8721625500110575 0.17938607563940234 LQEKEDLQELNDR ddPTM_A459_Selumetinib_30min_R1 2 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 131.08 0.0043956 74247000.0 7849.3 8389.099999999999 10853.400000000001 11831.3 10002.400000000001 8539.0 9410.2 8002.2 4975.3 7159.9 False True 8032.173417920932 7406.900272013215 9379.567893458743 9765.185556007002 9097.684686067152 8453.105412791667 8700.381037804516 7789.955661191098 8442.720718465325 8078.942908331952 0.9942109393590607 0.9168155235228055 1.1609895007161686 1.2087207035385779 1.1260984004088648 1.046313299735518 1.0769207229861304 0.9642295718115775 1.0450278971223084 1.0 12.979950820129698 -7.738050766242845 22.746512739140606 1.0034716264227934 1.078813336342303 0.14759347566463876 0.07975232421132418 170.66500697919128 165979.69271166075 0.0422671165670865 0.024373124489066846 1.82788653542748e-08 7.738050766242845 0.0753417099195095 LQEKEDLQELNDR ddPTM_A459_Selumetinib_30min_R2 2 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 111.72 0.01453 39089600.0 135843.0 128895.0 143215.0 140741.0 146072.0 91121.0 88469.0 99257.0 75191.0 125605.0 False True 128293.38988261491 138780.83203725162 134000.702820702 121571.8330082333 127721.1294597513 103672.09063591876 92582.98379799785 99545.821437119 90231.30101207571 121978.4572890176 1.0517708842524103 1.1377487067935463 1.098560399917165 0.9966664254506774 1.0470793966276104 0.8499213134846962 0.7590109422242513 0.8160934614974972 0.7397314494499656 1.0 16.896266849219785 -6.767854143483037 3.1557688964196204 0.8110140482024701 1.0733565976838422 0.7124218008316248 0.07399935777015408 0.1243328285410467 2.5652233425114477 0.026181904131224665 0.02427465573951385 1.7066554679543733e-07 6.767854143483037 0.26234254948137203 LQELASPPAGRPT(ph)PAPR ddPTM_A459_Selumetinib_30min_R1 1 LQELASPPAGRPTPAPR 17 1 Q8N3F8 Q8N3F8 MICALL1 MICAL-like protein 1 1 LQELAS(0.016)PPAGRPT(0.984)PAPR 108.96 0.023694 5065600.0 1256.7 1402.8 1517.4 1755.1 1406.4 1081.7 1527.6 1266.0 936.15 1006.5 True False 1285.9786648874717 1238.5595238559727 1311.3454144815735 1448.604732307344 1279.1913683200864 1070.8190801050184 1412.371902122184 1232.4215674524423 1588.5781763092302 1135.6940791402271 1.1323284047241111 1.0905749590537792 1.1546643049106344 1.275523716214145 1.1263520624220331 0.9428763429987043 1.2436200276674991 1.085170372980585 1.3987729666706172 1.0 10.149358554412208 LQELES(ph)CSGLGSTSDDTDVR ddPTM_A459_Selumetinib_30min_R1 1 LQELESCSGLGSTSDDTDVR 20 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 LQELES(0.362)CS(0.119)GLGS(0.309)T(0.1)S(0.1)DDT(0.009)DVR 86.189 0.010022 0.0 235.92 335.05 167.41 275.69 258.99 267.58 153.55 192.76 0.0 54.277 True False 241.4164769795914 295.82219023948096 144.67664151730597 227.54591684223806 235.5644002283982 264.88838814320115 141.96759987618574 187.64737862727705 0.0 61.243981652751245 3.9418808259137137 4.830224656469438 2.362299733182137 3.7154004475477485 3.846327326724617 4.3251333599617725 2.31806613556139 3.0639317295081097 0.0 1.0 5.936496174654315 -8.00434661806995 1.5744140857823807 0.5249692448891399 3.7530187534850263 0.6938480505118989 0.8029876146350855 0.21907193111817763 0.9737411002567491 0.6916897031475913 0.22999182089655865 9.900414599700092e-09 8.00434661806995 3.2280495085958867 LQELESCS(ph)GLGSTSDDTDVR ddPTM_A459_Selumetinib_30min_R2 1 LQELESCSGLGSTSDDTDVR 20 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 LQELES(0.176)CS(0.752)GLGS(0.026)T(0.026)S(0.02)DDTDVR 82.609 0.014583 0.0 1360.7 1387.3 2363.1 3281.8 2376.3 2297.7 1202.9 1042.8 1452.1 2539.4 True False 1285.0777413136786 1493.7014491274244 2211.060718748742 2834.8131785792284 2077.767949608462 2614.1873185561017 1258.8372335011313 1045.8343753551671 1742.5605750639727 2466.0809238464312 0.5211012051094004 0.6056984726996091 0.8965888740180005 1.1495215550987161 0.8425384299099544 1.060057394417805 0.5104606346565788 0.4240876141744543 0.706611270625313 1.0 11.268004426866902 -7.278483004882627 24.668389222153305 0.6122971831120771 0.8509484294909966 0.12593548740251093 0.22560478414216864 1232.3718133273057 1783687.0417779963 0.09878464874508926 0.06679586809033372 5.2664382348747364e-08 7.278483004882627 0.23865124637891943 LQELESCSGLGS(ph)TSDDTDVR ddPTM_A459_Selumetinib_30min_R1 1 LQELESCSGLGSTSDDTDVR 20 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 LQELESCSGLGS(0.764)T(0.233)S(0.003)DDTDVR 219.21 1.8144999999999998e-19 10632000.0 1650.3 1906.9 1736.6 1653.6 1626.9 1951.1 2157.2 2137.6 1155.6 1472.3 True False 1688.748779075193 1683.6392615062398 1500.7792584609845 1364.8298019163726 1479.747182252524 1931.4737054570583 1994.4806672283148 2080.9039040966354 1960.9687983153824 1661.2840464164494 1.0165322316300982 1.01345658807596 0.9033851024442874 0.8215511398309294 0.8907249699077542 1.1626390499706742 1.2005657139311021 1.2525876646954786 1.1803934447847024 1.0 10.698083051111828 -6.7698249909330235 21.17601882393412 1.177607447608264 0.9264079041261661 0.6629488142421258 0.08150059531364813 16.65679802753519 42061.612297240754 0.02969673717065725 0.026736591813030543 1.698928137162782e-07 6.7698249909330235 -0.25119954348209794 LQELESCSGLGST(ph)SDDTDVR ddPTM_A459_Selumetinib_30min_R1 1 LQELESCSGLGSTSDDTDVR 20 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 LQELESCSGLGS(0.295)T(0.627)S(0.078)DDTDVR 135.73 0.00025402 11040000.0 410.35 392.75 527.84 586.8 563.78 497.63 359.93 601.44 274.92 409.05 True False 419.9103565978946 346.7666474154784 456.1622272175783 484.32639560022204 512.7861985434436 492.6242940118886 332.78019031869445 585.4878574475491 466.51916063764685 461.5555519844111 0.9097720844057291 0.7512999159572245 0.9883148956964232 1.0493350009937266 1.1109956241210217 1.0673131151686954 0.7209970476748463 1.2685100524309667 1.0107540871990277 1.0 8.850360488239925 -5.415581662239256 5.1114079536384365 1.034442683935664 0.8325864283371933 0.26558021026873435 0.13219905684971003 0.2825481839259731 10.940118515968395 0.03461429744802797 0.07390074214408279 3.8407703274982275e-06 5.415581662239256 -0.20185625559847065 LQELESCSGLGST(ph)SDDTDVR ddPTM_A459_Selumetinib_30min_R2 2 LQELESCSGLGSTSDDTDVR 20 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 LQELES(0.001)CS(0.005)GLGS(0.235)T(0.717)S(0.042)DDTDVR;LQELESCSGLGS(0.066)T(0.848)S(0.085)DDTDVR 163.15 3.804e-08 1724700.0 17904.1 16685.2 21862.2 20336.4 26556.3 14161.4 15948.4 17279.6 15675.8 21737.8 True False 16909.06179779101 17964.90118862604 20455.60985376358 17566.54723775326 23220.060177665786 16112.004305610142 16690.032201155063 17329.88077520822 18811.398018447642 21110.173232412748 0.800991143541574 0.8510068103582671 0.9689929887622075 0.8321365743593913 1.0999464534006522 0.7632341112611822 0.7906155964428108 0.8209255596538529 0.8911058100444412 1.0 14.365650797197917 LQELESCSGLGSTS(ph)DDTDVR ddPTM_A459_Selumetinib_30min_R1 1 LQELESCSGLGSTSDDTDVR 20 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 LQELESCS(0.001)GLGS(0.046)T(0.24)S(0.713)DDTDVR 117.55 0.00026230000000000003 4322100.0 595.69 893.89 654.91 675.06 812.67 611.23 787.94 918.67 452.44 658.72 True False 609.5684179890333 789.2329432418135 565.9768191631258 557.1734434456131 739.1641419885415 605.0815811524361 728.5050514258664 894.3038873392849 767.7576350898336 743.2731284761559 0.8201136226177833 1.0618343553733518 0.7614654660306104 0.7496214003968087 0.9944717677389487 0.8140770303279531 0.9801310225212007 1.2031968506284754 1.0329414661658431 1.0 9.537748641037414 -7.52153306669959 6.498232402518121 1.0901303476811373 0.8731151737408545 0.4550172030486831 0.10420496741254351 0.12402647105644178 26.04857265116959 0.04699194587121231 0.02859762247510257 3.0093100346259514e-08 7.52153306669959 -0.2170151739402828 LQELNAHIVVS(ph)DPEDITDCPR ddPTM_A459_Selumetinib_30min_R1 4 LQELNAHIVVSDPEDITDCPR 21 0 Q16513-3;Q16513-2;Q16513;B1AL79 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 LQELNAHIVVS(0.986)DPEDIT(0.014)DCPR;LQELNAHIVVS(0.999)DPEDIT(0.001)DCPR;LQELNAHIVVS(0.996)DPEDIT(0.004)DCPR;LQELNAHIVVS(0.987)DPEDIT(0.013)DCPR 133.53 2.8405e-05 40677300.0 6302.92 7307.780000000001 8266.02 8999.35 8366.97 6836.57 7308.07 6889.81 3636.79 5591.18 True False 6449.765772652621 6452.181720305246 7143.539885997744 7427.782461221641 7610.179040808532 6767.8003129089075 6756.816396139086 6707.069857543054 6171.367009367777 6308.862415705175 1.0223341939739696 1.0227171390270446 1.132302373279648 1.1773568627413786 1.2062680304873792 1.0727449525704127 1.071003922881371 1.0631187392590125 0.9782059906719286 1.0 12.62316417336002 -7.921572114486922 1.4782046160488154 0.9889337527570599 1.1093355762618697 0.37593222715289576 0.05677624115410286 0.5033940638254278 1.9891577027090008 0.055899506342882 0.019525315855705404 1.1979201923347205e-08 7.921572114486922 0.12040182350480988 LQFHDVAGDIFHQQCK ddPTM_A459_Selumetinib_30min_R1 2 LQFHDVAGDIFHQQCK 16 0 P11413-3;P11413;P11413-2 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 ; 160.87 2.875e-05 97042000.0 12821.8 15473.5 15378.8 16298.099999999999 14607.2 13503.1 13587.7 13808.3 7491.9 11011.2 False True 13120.522993120223 13661.855426565004 13290.443429701598 13451.942788227634 13285.981339110618 13367.271073833841 12562.768849479966 13442.059028320347 12713.207113273644 12424.59477817076 1.0560121458586453 1.099581569498591 1.0696882809451524 1.0826866411661056 1.0693291472534188 1.0758717940096771 1.011121012296672 1.0818911415877488 1.023229114530959 1.0 13.600911179340487 -8.306888527611322 0.39914837680678344 0.9963883627259027 1.0830011452495338 0.5453278821265511 0.021595307710669753 0.8960509452265821 0.4075045077734943 0.029118517670130684 0.018034824204699988 4.933004054206076e-09 8.306888527611322 0.08661278252363114 LQGQVS(ph)AK ddPTM_A459_Selumetinib_30min_R2 1 LQGQVSAK 8 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 LQGQVS(1)AK 101.66 0.01685 6073100.0 35496.0 36013.0 33746.0 38724.0 31989.0 38279.0 35963.0 39797.0 27747.0 35073.0 True False 33523.2744217464 38775.08129995382 31574.819099866723 33449.72439737401 27970.255834711552 43551.58478783526 37635.350759332585 39912.80268125196 33297.17531595624 34060.35135940216 0.9842316090051871 1.138422821620429 0.9270256424160663 0.9820722060208699 0.8211969259967874 1.2786592929791696 1.1049607316791104 1.1718259233469202 0.977593418359284 1.0 15.055805697180482 -6.7603199837865215 24.99999984989323 1.1172440261250363 0.9781315958160517 0.28231303941286834 0.10743361957614185 40.36055622932942 901400.3288033316 0.03636797525856891 0.034442820454254744 1.7365209062309168e-07 6.7603199837865215 -0.13911243030898457 LQGSGVS(ph)LASK ddPTM_A459_Selumetinib_30min_R2 1 LQGSGVSLASK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 LQGS(0.273)GVS(0.718)LAS(0.009)K 82.705 0.039481 5238600.0 60353.0 67810.0 59665.0 67846.0 67191.0 61238.0 64047.0 57961.0 53366.0 54774.0 True False 56998.82187220135 73010.80895648427 55826.21885834019 58605.25775912197 58749.8658848387 69672.97863678413 67025.3124067228 58129.656914039886 64040.69117062457 53192.53230005685 1.0715568409240863 1.3725762959475842 1.049512336495409 1.1017572434516212 1.104475822911253 1.3098263162911998 1.260051167119396 1.0928161228747848 1.2039413880387138 1.0 15.69893609952604 -10.983210104464227 2.7942255997928815 0.9945583792045968 1.176192821693794 0.20006172131838573 0.10433545792329198 13130949.670025963 14252110.072015015 558861.5548733847 0.027475337741092395 1.039417191383069e-11 10.983210104464227 0.18163444248919725 LQHSTS(ph)ILR ddPTM_A459_Selumetinib_30min_R2 2 LQHSTSILR 9 0 A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;A0A2R8Y695 A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 LQHS(0.033)T(0.109)S(0.859)ILR;LQHST(0.23)S(0.77)ILR 103.43 0.010085 7045600.0 49874.0 45312.0 56373.0 64863.0 70276.0 48550.0 41762.0 54061.0 43555.0 49716.0 True False 47102.202741440706 48787.284698956115 52746.02255428161 56028.547505083945 61447.300604588694 55237.32180698038 43704.0157498331 54218.30855971963 52267.217028380466 48280.56990231914 0.9755933460756057 1.0104952115864032 1.0924896425414392 1.160478172035675 1.2727128268972048 1.1440900950161956 0.9052091936415563 1.1229840217175082 1.082572495190655 1.0 15.559155085269497 -10.631162240142626 14.592766283760735 1.0000011915624476 1.0884804169865503 0.06287241375173047 0.09791460279296181 0.0 0.0 0.10295609521336865 0.02497052090387458 2.3379636783556888e-11 10.631162240142626 0.08847922542410269 LQINS(ph)PPFDQPMSR ddPTM_A459_Selumetinib_30min_R1 1 LQINSPPFDQPMSR 14 0 Q00537-2;F5H6Z0;Q00537;F8VQZ9 Q00537-2 CDK17 Cyclin-dependent kinase 17 1 LQINS(0.998)PPFDQPMS(0.002)R 147.51 0.0004773 5432100.0 3814.7 4208.5 6187.6 6610.1 4952.3 3893.1 3431.1 3463.5 2237.0 2924.7 True False 3903.575087885922 3715.766863521428 5347.357906053894 5455.770121944493 4504.365339399578 3853.9389486519785 3172.289364605541 3371.6367289664568 3796.0256159843448 3300.1137339904863 1.1828607746696453 1.1259511529102166 1.620355641375998 1.6532066958029943 1.3649121522708598 1.1678200387329707 0.9612666775486005 1.0216728878884684 1.1502711488049848 1.0 11.688300030538198 -6.874872674469914 3.1658822961597672 1.0373980887586522 1.4043880426321644 0.5251813298406627 0.16030411626129112 0.22625103900846036 4.5124731149454975 0.06797041961505372 0.059446923278850185 1.333912448448977e-07 6.874872674469914 0.3669899538735122 LQINS(ph)PPFDQPMSR ddPTM_A459_Selumetinib_30min_R2 3 LQINSPPFDQPMSR 14 0 Q00537-2;F5H6Z0;Q00537;F8VQZ9 Q00537-2 CDK17 Cyclin-dependent kinase 17 1 LQINS(1)PPFDQPMSR;LQINS(1)PPFDQPMSR;LQINS(0.995)PPFDQPMS(0.005)R 153.32 9.9081e-05 13191700.0 45160.0 45564.0 52003.0 56908.0 54563.0 39959.0 49641.0 57198.0 49582.0 61409.0 True False 42650.187989803555 49058.612288648415 48657.183596585346 49157.03222822435 47708.308140591056 45462.98953831369 51949.404861775394 57364.43671036132 59499.78543683068 59635.96261025657 0.7151756444100444 0.8226347013003695 0.8159033822356206 0.8242850467508009 0.799992253875112 0.7623418412046338 0.8711086832166067 0.961910132737514 0.997716525943987 1.0 15.863894969174073 -7.664443014346433 2.3020045149880684 0.9950001207740207 0.7947197748039042 0.8846651118635642 0.03180743456672642 0.09808504769796222 1.0397289997193513 0.019985643422264367 0.009366684775229558 2.165494004482381e-08 7.664443014346433 -0.20028034597011646 LQLEETMPS(ph)PYGR ddPTM_A459_Selumetinib_30min_R2 4 LQLEETMPSPYGR 13 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 LQLEETMPS(1)PYGR;LQLEETMPS(0.999)PYGR;LQLEETMPS(1)PYGR;LQLEETMPS(1)PYGR 132.06 0.0016491 4764600.0 34581.7 31890.899999999998 38725.7 39676.2 41292.7 32098.399999999998 35752.6 38068.7 34814.8 34329.7 True False 32659.787555513507 34336.82948459435 36234.13062335414 34272.2331147374 36105.14186457824 36519.66323973591 37415.16674243288 38179.473614387425 41778.732806788226 33338.51236172748 0.9796414189436614 1.0299448611274251 1.0868550531052137 1.0280072710767332 1.082985991481337 1.0954197009000433 1.1222806325751171 1.1452062767568885 1.253167278536102 1.0 15.024902109061482 -6.580225744832823 0.8785278754323816 1.1450129055839655 1.0218755429821564 0.33221307754156415 0.06220546763461085 0.6426186264426748 1.0900648251976404 0.03521374436140924 0.039950705401046366 2.6289011425802374e-07 6.580225744832823 -0.12313736260180908 LQLERPVS(ph)PETQADLQR ddPTM_A459_Selumetinib_30min_R1 3 LQLERPVSPETQADLQR 17 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 LQLERPVS(0.922)PET(0.078)QADLQR;LQLERPVS(0.741)PET(0.259)QADLQR;LQLERPVS(0.984)PET(0.016)QADLQR 95.307 0.0035454 106846000.0 6483.7 7444.7 5542.5 5846.3 6212.599999999999 5971.0 6516.7 6129.2 3974.14 6477.6 True False 6634.757594915971 6573.071063052869 4789.858942773239 4825.353453642772 5650.671426923618 5910.9371612342275 6025.140072374729 5966.633705552535 6743.825320298627 7309.063057167152 0.9077439260029413 0.8993041942096012 0.6553314570294175 0.6601876897082051 0.7731047581239101 0.8087133898014542 0.8243382257410643 0.8163335928127953 0.9226661840994433 1.0 12.835470764791514 -8.37131938046542 1.0787894754181995 1.0016230142225149 0.7783917998997895 0.43931919942504183 0.07906146026216526 0.5106884087390148 1.2707418453444594 0.08344230628059615 0.02754950625808866 4.252855428199952e-09 8.37131938046542 -0.2232312143227254 LQLERPVS(ph)PETQADLQR ddPTM_A459_Selumetinib_30min_R2 3 LQLERPVSPETQADLQR 17 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 LQLERPVS(0.564)PET(0.436)QADLQR;LQLERPVS(0.795)PET(0.205)QADLQR;LQLERPVS(0.994)PET(0.006)QADLQR 108.71 0.015813 100210500.0 83295.8 65360.4 73956.4 74408.0 74311.0 61063.8 79656.8 73499.5 59981.9 69907.1 True False 78666.55289550665 70373.33251318963 69198.12574164 64273.50203904049 64975.3878312311 69474.78416801423 83360.99903695483 73713.37137650278 71979.95603431555 67888.70038254105 1.1587576791459298 1.036598610912392 1.0192878248032524 0.9467481580420667 0.9570869300061138 1.0233630011553598 1.2279068323186342 1.0857973559832597 1.0602641622055067 1.0 16.050883847117134 -7.043959018624415 24.998510842007004 1.104212324913045 1.0169260094314374 0.16097494921120115 0.07579284274947182 720.6183135278686 409797.1435157112 0.02975574596182949 0.023050040662922735 9.037347489153857e-08 7.043959018624415 -0.0872863154816077 LQLERPVSPET(ph)QADLQR ddPTM_A459_Selumetinib_30min_R1 1 LQLERPVSPETQADLQR 17 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 LQLERPVS(0.421)PET(0.579)QADLQR 137.32 0.0053036 15261000.0 1761.3 2066.2 1446.0 1648.9 1578.2 1488.5 1854.8 1793.5 982.74 1629.5 True False 1802.334863106792 1824.2883434496803 1249.641142309446 1360.950568686445 1435.4520886538412 1473.5270414498655 1714.890942691953 1745.9305538909598 1667.6380035102632 1838.6621976741192 0.9802425183846817 0.9921824388174066 0.6796469432450527 0.7401852120569116 0.7807046288707448 0.8014125940664117 0.932684070440598 0.9495656984189572 0.9069844398932011 1.0 10.844440734229433 -7.303702247813099 6.6041712494184 0.9439377366828448 0.8234595110161343 0.27565814912015496 0.09360720974568132 0.35011236404743934 42.44016826776588 0.0436904509770838 0.0296085222683548 4.969329017578123e-08 7.303702247813099 -0.1204782256667104 LQLGT(ph)PPPLLAAR ddPTM_A459_Selumetinib_30min_R1 2 LQLGTPPPLLAAR 13 0 Q9P2N5 Q9P2N5 RBM27 RNA-binding protein 27 1 LQLGT(1)PPPLLAAR;LQLGT(1)PPPLLAAR 141.59 0.0019195 45789000.0 7405.700000000001 8000.099999999999 8635.0 9246.9 8187.7 6353.4 7510.7 7123.9 3519.0 6894.6 True False 7578.238401016277 7063.4445728544115 7462.4144286597975 7632.102500810656 7447.123980655842 6289.490564425646 6944.161852100736 6934.951030311573 5971.4859824089945 7779.589069091125 0.9741180843503896 0.9079457166854729 0.9592298979271945 0.9810418561995204 0.957264440900074 0.808460512318607 0.8926129375766643 0.8914289647848676 0.7675837283146669 1.0 12.925478236320634 -6.735661229744557 24.975146375509773 0.8665187731243116 0.9548343482935006 0.3290832699792775 0.05963223650741743 244.83802129481103 237210.6221854876 0.018644059492357718 0.018637901191631525 1.8379714890862182e-07 6.735661229744557 0.08831557516918898 LQLQGLDLS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 LQLQGLDLSSR 11 0 P49454 P49454 CENPF Centromere protein F 1 LQLQGLDLS(0.878)S(0.122)R 100.73 0.015978 1835000.0 1145.2 1458.2 1268.0 1256.1 1055.3 1294.4 1392.8 1476.9 979.66 1198.5 True False 1171.8809318287053 1287.4732661012117 1095.8125646254348 1036.7457149172437 959.8483013283476 1281.3795112211665 1287.739974650287 1437.7278143526942 1662.4114684645613 1352.3391493786014 0.866558460847032 0.9520343078826081 0.8103089858257521 0.7666314440380044 0.7097689228100784 0.947528223086612 0.9522315280467938 1.0631414575355072 1.2292859148745623 1.0 10.401241291140002 -7.4941636918577155 1.6472095109309945 1.117343055576465 0.830178919031096 0.6521674663031222 0.08485910234563253 0.24420529365881338 1.2869270317918104 0.05745339634193965 0.028617735100992404 3.205061063045934e-08 7.4941636918577155 -0.287164136545369 LQLQGLDLS(ph)SR ddPTM_A459_Selumetinib_30min_R2 2 LQLQGLDLSSR 11 0 P49454 P49454 CENPF Centromere protein F 1 LQLQGLDLS(0.977)S(0.023)R;LQLQGLDLS(0.905)S(0.095)R 145.81 0.00069515 4520000.0 17613.4 16010.5 18610.5 21453.0 19479.2 17021.9 18280.2 14907.7 15184.5 17942.8 True False 16634.51774002671 17238.453868128472 17413.120691580327 18531.0643915108 17032.04874974252 19366.512215576517 19130.265521529112 14951.078938897403 18221.824290378685 17424.744743006915 0.9546491489754908 0.9893088319154169 0.9993328997584741 1.0634912972798576 0.977463314438394 1.1114373553936217 1.0978792403376052 0.8580371855890588 1.0457441161479086 1.0 14.088849901600371 -2.268539785126231 20.861790974217417 1.010803718372387 0.26659530381668506 0.0 0.07072407630000759 0.0 0.0 0.016282066149859345 0.0 0.0053884048066935785 2.268539785126231 -0.744208414555702 LQLQGLDLSS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LQLQGLDLSSR 11 0 P49454 P49454 CENPF Centromere protein F 1 LQLQGLDLS(0.089)S(0.911)R 149.82 0.00062438 8959200.0 1290.6 1613.4 1404.3 1316.4 1571.2 1144.0 1662.2 1399.8 845.24 1152.2 True False 1320.6684689295546 1424.5023779506894 1213.6037732677426 1086.5154518884333 1429.0852374178903 1132.4923986688918 1536.8189157551035 1362.67275680879 1434.3105461129235 1300.0960933784108 1.0158237346115584 1.0956900687617621 0.933472363657435 0.8357193421488023 1.0992150847129232 0.8710836102322356 1.1820810196895124 1.0481323371011508 1.1032342558508463 1.0 10.344402545082737 -7.26535227217514 24.99624141805941 1.0873729245238786 0.9780504318661026 0.25434464074916263 0.09056991423284345 506.64028408123033 3236490.0976849496 0.03664945990930308 0.0257753157740591 5.428098598989407e-08 7.26535227217514 -0.10932249265777594 LQLS(ph)PWESSVVNR ddPTM_A459_Selumetinib_30min_R2 1 LQLSPWESSVVNR 13 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LQLS(0.943)PWES(0.049)S(0.009)VVNR 93.228 0.017396000000000002 3582200.0 30491.0 28453.0 26051.0 26821.0 25847.0 24373.0 25146.0 22610.0 17646.0 23790.0 True False 28796.432285143936 30635.253609185176 24374.907022184194 23167.933531194303 22599.868784888225 27730.15951393477 26315.338825853723 22675.791356713005 21175.693070435133 23103.12088615681 1.2464304033659155 1.3260223049580093 1.055048239685636 1.0028053631955989 0.9782171376867907 1.2002776443311796 1.1390382691379868 0.9815033851249138 0.9165728377036466 1.0 14.49580013088163 -5.271107206511993 20.32430291524447 1.0400794939120979 1.2862263496132202 0.6116583665184181 0.0802218935341563 33.96695129294275 71410.69963616035 0.022741692707732682 0.04875535543905179 5.3566441129778195e-06 5.271107206511993 0.24614685570112238 LQLSPWES(ph)SVVNR ddPTM_A459_Selumetinib_30min_R2 1 LQLSPWESSVVNR 13 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LQLS(0.074)PWES(0.569)S(0.357)VVNR 123.95 0.0023548 5350200.0 18285.0 17819.0 20397.0 21636.0 23085.0 25766.0 20216.0 18775.0 20358.0 19370.0 True False 17268.79290065452 19185.660002884422 19084.67922657444 18689.13947581821 20184.855917481524 29315.032619539787 21156.084057244057 18829.63214163144 24430.168850046386 18810.737770695985 0.918028474542686 1.0199312880100058 1.0145630362412053 0.9935356977296657 1.0730496678831059 1.55842014156445 1.124681249355447 1.001004446033206 1.2987352834243717 1.0 14.19926881305975 -6.5323854165784185 24.99683926359231 1.2058710316281214 0.9962033960799951 0.29811197530303846 0.15194675011211592 265.55922345270864 698256.3794130207 0.05064503806602508 0.050705568718705726 2.935043778120523e-07 6.5323854165784185 -0.20966763554812629 LQLSPWESS(ph)VVNR ddPTM_A459_Selumetinib_30min_R2 1 LQLSPWESSVVNR 13 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 LQLS(0.164)PWES(0.323)S(0.513)VVNR 90.229 0.021403 5966500.0 23597.0 23265.0 25606.0 25978.0 26243.0 23488.0 31692.0 22375.0 25046.0 27994.0 True False 22285.573206275338 25049.350691234435 23958.53783770484 22439.75158545042 22946.11972460332 26723.258797164897 33165.74079650666 22440.107545619343 30055.899843710642 27185.74048285303 0.819752296993036 0.9214150597455276 0.8812906108927326 0.8254235929164384 0.8440498333704103 0.9829880784016225 1.219968270403575 0.825436686551653 1.1055759125879951 1.0 14.730562504223657 -6.869058381658598 4.851643736246352 1.0328434149263455 0.8617550568168713 0.4406344766461602 0.09603817247660125 0.20691349966967829 7.970396594074617 0.0333427866714328 0.029443990258349526 1.351890818003718e-07 6.869058381658598 -0.1710883581094742 LQMEAPHIIVGTPGR ddPTM_A459_Selumetinib_30min_R1 2 LQMEAPHIIVGTPGR 15 0 P60842;P60842-2;J3KT12;J3QS69;J3QL43;J3KTB5;J3KSZ0;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 ; 101.9 0.009339 23174100.0 5200.8 6194.2 6275.1 6673.700000000001 5866.299999999999 5872.799999999999 5361.1 5437.6 3574.7 4474.0 False True 5321.96852100483 5468.980184394542 5422.975886656993 5508.2635758643555 5335.694200779387 5813.724964075759 4956.707910753628 5293.377184185937 6066.004814241952 5048.281480450447 1.0542139026150266 1.0833350330351543 1.074222169991423 1.0911165704993266 1.0569327842438958 1.151624565030596 0.9818604469557732 1.0485503244390446 1.2015979770012142 1.0 12.301576638549987 -14.522682905153172 0.0031093470978575282 8.945475732239273e-05 2.092995310904945 0.02416605173758346 0.060880277573139706 915199.48247646 215.4868604004158 76016.70943728797 69177.6170588967 3.0013531207364943e-15 14.522682905153172 2.0929058561476226 LQMEAPHIIVGTPGR ddPTM_A459_Selumetinib_30min_R2 2 LQMEAPHIIVGTPGR 15 0 P60842;P60842-2;J3KT12;J3QS69;J3QL43;J3KTB5;J3KSZ0;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 ; 84.40299999999998 0.030608 7282900.0 48469.0 51296.0 48953.0 57346.0 61824.0 47113.0 48637.0 47046.0 35696.0 53870.0 False True 45775.2870167801 55230.23825736345 45803.41727599643 49535.37587263222 54057.11640642746 53602.388100767625 50898.71687238717 47182.896071115436 42836.19742957341 52314.63312893094 0.8749996755967986 1.0557321145930034 0.875537388613862 0.946874190067449 1.0333077606260208 1.02461557875524 0.9729346041086784 0.9019062783988528 0.8188186529761635 1.0 15.67492692429559 -7.77839668536211 6.188452331053894 0.8943427990259561 0.9727453208028513 0.1324134146923377 0.07057596917215259 0.2670326482259331 36.24640997901519 0.03677451930545695 0.018390957462735037 1.665725041226578e-08 7.77839668536211 0.0784025217768951 LQMPS(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 LQMPSFK 7 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 LQMPS(1)FK 111.61 0.014918 16960000.0 3105.9 2433.3 3169.6 3690.0 2521.7 2257.5 2375.6 2867.7 1328.1 1679.8 True False 3178.2614269706387 2148.4081047895197 2739.185729366544 3045.6107698786955 2293.612680242295 2234.791599646001 2196.406579393468 2791.639280397605 2253.688699413862 1895.4186926376085 1.6768123261187555 1.133474156994758 1.445161293389364 1.6068274422473452 1.2100823365050661 1.1790490451142124 1.158797572232979 1.4728351531200965 1.1890189266191606 1.0 10.88830085552337 -6.292966315377518 24.305961231207863 1.222001493894221 1.4403900932982632 0.35310748417457816 0.17236263837122626 639.0209067655031 492656.6612212738 0.05290677172089425 0.05999703700616245 5.093703771623627e-07 6.292966315377518 0.2183885994040422 LQMPS(ph)FK ddPTM_A459_Selumetinib_30min_R2 2 LQMPSFK 7 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 LQMPS(1)FK;LQMPS(1)FK 83.948 0.038343 18153800.0 80813.0 65919.0 86072.0 77133.0 64234.0 37261.0 47360.0 57789.0 56272.0 62469.0 True False 76321.73698007078 70974.77533700771 80534.22122810777 66627.35233815332 56164.35066075407 42393.3645283192 49562.33384205968 57957.15642251603 67527.97237104876 60665.35765604577 1.258077755228807 1.1699391230727298 1.3275158070395372 1.0982767581444133 0.9258059761089508 0.698806801217208 0.8169791748869778 0.9553583570893224 1.113122463629275 1.0 15.88858529463129 -6.096043142934634 3.0725547675276834 0.899737862679153 1.2422518219438572 0.6484446467228389 0.1099186077633366 0.1687812000666602 3.061550429124086 0.036497763203825334 0.050448990123812626 8.015984284214161e-07 6.096043142934634 0.3425139592647042 LQNAT(ph)PTNFK ddPTM_A459_Selumetinib_30min_R1 2 LQNATPTNFK 10 0 Q9NXF1-2;Q9NXF1 Q9NXF1-2 TEX10 Testis-expressed sequence 10 protein 1 LQNAT(0.995)PT(0.005)NFK;LQNAT(0.997)PT(0.003)NFK 107.85 0.02582 28301000.0 3520.1 3462.3 4328.9 4609.0 3735.6000000000004 3065.9 3240.6 3047.0 1986.84 2795.6000000000004 True False 3602.111481077737 3056.9323064203995 3741.0591569456155 3804.1246716452324 3397.715639573746 3035.0598296144717 2996.1589329779736 2966.1836619491232 3371.5223669478482 3154.4424914499964 1.1419169919379197 0.9690879813805784 1.1859652433308334 1.205957845786118 1.0771208062226947 0.9621541168814752 0.949822018026626 0.9403194605667587 1.068817192288729 1.0 11.623169333961041 -6.635609451309386 4.510896137444442 0.9787793073109547 1.121222219475841 0.4916142505203144 0.06808299836724918 0.194019129975148 6.781136793643855 0.0240556585708545 0.02396008940215436 2.3141448995142368e-07 6.635609451309386 0.14244291216488625 LQNAT(ph)PTNFK ddPTM_A459_Selumetinib_30min_R2 1 LQNATPTNFK 10 0 Q9NXF1-2;Q9NXF1 Q9NXF1-2 TEX10 Testis-expressed sequence 10 protein 1 LQNAT(0.971)PT(0.029)NFK 108.56 0.024796 6807900.0 33148.0 37478.0 26900.0 35007.0 34241.0 34086.0 37113.0 35219.0 29167.0 40215.0 True False 31305.766861957658 40352.44208923638 25169.2832865055 30238.986209556664 29939.339461576114 38781.037098099536 38838.828038014355 35321.481459180664 35001.21499407123 39053.88845888173 0.801604349715861 1.0332503031477094 0.6444757303233768 0.7742887431399841 0.7666160949145445 0.9930134649442278 0.9944932392303572 0.9044293117283119 0.8962286823480485 1.0 15.253178579160213 -6.761579623282748 24.999999971120957 0.9539635499033358 0.8062622385341217 0.39183156706101596 0.09559715477608118 4.440481505351618 791437.0608855595 0.03388701029796172 0.03179517864827847 1.7314915510535196e-07 6.761579623282748 -0.14770131136921405 LQNATPT(ph)NFK ddPTM_A459_Selumetinib_30min_R2 1 LQNATPTNFK 10 0 Q9NXF1-2;Q9NXF1 Q9NXF1-2 TEX10 Testis-expressed sequence 10 protein 1 LQNAT(0.308)PT(0.692)NFK 118.23 0.013507 6996500.0 45402.0 46549.0 39267.0 56082.0 46114.0 46177.0 44303.0 45727.0 36610.0 52115.0 True False 42878.738598606345 50119.158621374205 36740.60397067703 48443.534853153826 40320.74705560939 52537.4625969296 46363.177284729056 45860.05799948765 43933.02296886715 50610.30453896854 0.8472333646123567 0.9902955352261086 0.7259510549356164 0.9571871834095295 0.7966904649736601 1.0380783730806677 0.9160817684673421 0.9061407240530763 0.8680647818477348 1.0 15.627143535096199 -6.746257636964744 24.999310255624437 0.9379574998600444 0.86808372730059 0.19319697501056476 0.08298067501220968 471.45761951984116 776333.6971473399 0.026298915574500852 0.02620269628610224 1.7936692508882015e-07 6.746257636964744 -0.06987377255945437 LQPQEIS(ph)PPPTANLDR ddPTM_A459_Selumetinib_30min_R1 4 LQPQEISPPPTANLDR 16 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-6;B4DWJ1;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 LQPQEIS(0.94)PPPT(0.06)ANLDR;LQPQEIS(0.999)PPPT(0.001)ANLDR;LQPQEIS(0.985)PPPT(0.015)ANLDR;LQPQEIS(0.999)PPPT(0.001)ANLDR 132.5 0.00061388 168410000.0 6896.4 8387.099999999999 8830.1 9428.0 9107.1 7615.000000000001 7984.099999999999 7508.599999999999 4037.6099999999997 6264.2 True False 7057.072701941567 7405.134432942988 7631.020920267388 7781.576785478688 8283.364412989094 7538.4000138667925 7381.852908964213 7309.447536629867 6851.529274633242 7068.271088475129 0.9984156823651231 1.0476585207685536 1.0796163340013694 1.1009165732432942 1.1719081383982548 1.066512577051298 1.0443647133172895 1.034120995804473 0.9693359505982607 1.0 12.787141657106618 -7.808302455470584 1.7054736615086363 0.9872540656725859 1.080380858720888 0.4117422460343605 0.042388644265993376 0.40772338994352575 2.2400383713609826 0.03654252974025563 0.013933772989200946 1.554882388548774e-08 7.808302455470584 0.09312679304830218 LQPQEIS(ph)PPPTANLDR ddPTM_A459_Selumetinib_30min_R2 3 LQPQEISPPPTANLDR 16 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-6;B4DWJ1;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 LQPQEIS(0.999)PPPT(0.001)ANLDR;LQPQEIS(0.999)PPPT(0.001)ANLDR;LQPQEIS(0.937)PPPT(0.063)ANLDR 110.34 0.0028131 173002200.0 83564.0 71237.0 105327.0 97764.0 98513.0 72541.0 69791.0 64363.0 65099.5 84155.0 True False 78919.84741319626 76700.6488369424 98550.37549136653 84448.37454769337 86136.91622260588 82532.86428836593 73036.41978824297 64550.285674131774 78121.2190320067 81725.22648905129 0.9656730339409844 0.9385186451238281 1.2058746084303518 1.0333207771410324 1.0539819823459973 1.0098823562076373 0.8936826843548442 0.7898452955989 0.9559009180901149 1.0 16.318493849757694 -7.188852837614245 3.783510520257645 0.8916397695129732 1.0416760896327 0.3432631259193536 0.08364223879959848 0.24633317443193903 6.860843161341397 0.034790112341528685 0.025836985596548297 6.473619397152321e-08 7.188852837614245 0.15003632011972678 LQPS(ph)PNRR ddPTM_A459_Selumetinib_30min_R2 1 LQPSPNRR 8 1 O43150;O43150-2 O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 1 LQPS(1)PNRR 66.056 0.042709 4898600.0 10033.0 9707.5 12824.0 12382.0 11736.0 7757.2 9690.4 12129.0 9656.4 11356.0 True False 9475.406025281209 10452.0340354678 11998.91780171548 10695.550239858612 10261.618758828807 8825.6838871495 10141.022801163323 12164.293381935951 11587.949822359162 11028.122773568582 0.859203893521315 0.9477618494163385 1.0880290370427894 0.9698432325665565 0.9304955131097309 0.8002888676849218 0.9195602016209506 1.1030248421871456 1.050763585089235 1.0 13.428899613293524 -7.752547145935836 24.995203847765563 1.0576706636425475 0.9339217668413001 0.3581456374876084 0.07370216068329259 218.46856397030476 614098.2405867166 0.03889453894955173 0.02203013714945395 1.7678802906009355e-08 7.752547145935836 -0.12374889680124734 LQPSS(ph)SPENSLDPFPPR ddPTM_A459_Selumetinib_30min_R1 3 LQPSSSPENSLDPFPPR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 LQPS(0.124)S(0.42)S(0.42)PENS(0.037)LDPFPPR;LQPS(0.182)S(0.624)S(0.194)PENSLDPFPPR;LQPS(0.211)S(0.723)S(0.067)PENSLDPFPPR 249.54 1.7221e-30 274498300.0 12306.0 13102.199999999999 13515.6 14001.9 14123.1 11293.8 12608.4 10638.2 6582.8 9861.6 True False 12592.705856692319 11568.188332952466 11680.255755876593 11556.731013215325 12845.668098635826 11180.194625949942 11657.338236918917 10356.04037825637 11170.53081131057 11127.432420118497 1.1316811804603364 1.0396098485430545 1.0496811227321934 1.0385802022325161 1.1544143890203047 1.0047416334549963 1.047621571337728 0.9306765466876757 1.003873165844993 1.0 13.441833118492319 -7.3078352128707005 1.891780650314327 0.9793978234321298 1.073975701912908 0.4355368638328273 0.04616105924890265 0.32524898842988587 2.2691506339532483 0.0239563071671333 0.014500820732886171 4.9222626880978014e-08 7.3078352128707005 0.09457787848077814 LQPSS(ph)SPENSLDPFPPR ddPTM_A459_Selumetinib_30min_R2 4 LQPSSSPENSLDPFPPR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 LQPS(0.217)S(0.745)S(0.038)PENSLDPFPPR;LQPS(0.188)S(0.586)S(0.188)PENS(0.039)LDPFPPR;LQPS(0.085)S(0.305)S(0.305)PENS(0.305)LDPFPPR;LQPS(0.176)S(0.592)S(0.232)PENS(0.001)LDPFPPR 244.18 4.8141e-23 131012000.0 376752.9 355895.1 415983.2 468094.2 499158.6 329436.9 361021.0 392265.4 310995.1 434244.1 True False 355814.4820793549 383191.1097868883 389219.2938002638 404338.9624524651 436449.83413349756 374813.8426445731 377809.19184953975 393406.8273709673 373202.80992912146 421706.34453133075 0.8437494163736007 0.9086681164656252 0.9229628599323733 0.9588164079006989 1.0349615076779368 0.8888029490311029 0.8959058756145186 0.9328928351983546 0.8849826775641368 1.0 18.685879201425053 -4.7382193361105385 1.7837177218079976 0.938451013945396 0.805688764434177 0.2932573219690858 0.04566503482900526 1.4093140751282616 4.212821093749716 0.013049706888619677 0.3309922538656182 1.8271771854060404e-05 4.7382193361105385 -0.13276224951121895 LQPSSS(ph)PENSLDPFPPR ddPTM_A459_Selumetinib_30min_R1 1 LQPSSSPENSLDPFPPR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 LQPS(0.009)S(0.041)S(0.898)PENS(0.052)LDPFPPR 156.67 4.503899999999999e-05 6475800.0 1465.6 1500.4 1955.8 2020.5 1930.1 1767.0 1830.3 1694.9 909.27 1362.1 True False 1499.7456284388318 1324.7324704829643 1690.2131024403989 1667.6576044823605 1755.522795786831 1749.2255843076325 1692.2389974170162 1649.9457461888976 1542.9647795467527 1536.938802977549 0.9758004844001194 0.8619292244535227 1.0997270022501273 1.085051402991171 1.1422203619206008 1.1381231190980508 1.1010451386474207 1.073527288784965 1.0039207654576288 1.0 10.585844006360583 -5.271001720705463 24.986665244106078 1.0882433107841334 0.9188648538050382 0.6019483743617364 0.052253745879979885 366.78818278235894 958428.9017026577 0.013651058722701177 0.029021951566461344 5.357945346532828e-06 5.271001720705463 -0.16937845697909515 LQPSSS(ph)PENSLDPFPPR ddPTM_A459_Selumetinib_30min_R2 1 LQPSSSPENSLDPFPPR 17 0 H3BUF6;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 LQPSS(0.024)S(0.976)PENSLDPFPPR 242.9 7.7345e-23 27418000.0 132120.0 133210.0 174940.0 161430.0 185620.0 121230.0 121740.0 130750.0 120900.0 165140.0 True False 124777.29931826495 143426.77866233984 163684.55086027028 139442.95551771758 162300.7561361457 137928.33208362976 127401.1512232337 131130.46085317232 145083.37822824463 160371.97911475104 0.77804925777578 0.8943381471878801 1.0206555519474445 0.8694970049471167 1.0120268954217655 0.860052565572804 0.7944102949061587 0.8176644172941488 0.9046678791962345 1.0 17.291062564336556 -6.934458606111417 24.9999662758827 0.8587346585113748 0.9190136590493692 0.03387037651636482 0.0835490431718104 136.27945830410897 51980.60795821831 0.029165632876357855 0.025721668154364 1.1628973849025407e-07 6.934458606111417 0.0602790005379944 LQQGAGLES(ph)PQGQPEPGAAS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 4 LQQGAGLESPQGQPEPGAASPQR 23 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 2 LQQGAGLES(1)PQGQPEPGAAS(1)PQR;LQQGAGLES(1)PQGQPEPGAAS(1)PQR;LQQGAGLES(1)PQGQPEPGAAS(1)PQR;LQQGAGLES(1)PQGQPEPGAAS(1)PQR 151.02 2.6742e-07 32273700.0 4927.04 5436.740000000001 5571.78 5530.48 6688.400000000001 4859.17 5556.17 5198.0 2985.6800000000003 4415.73 True False 5041.830445649056 4800.203953328146 4815.162879596769 4564.6854879671355 6083.435400932927 4810.291161573357 5137.063623601869 5060.132154516423 5066.480894560637 4982.531958352585 1.0119012758557553 0.9634065558337686 0.9664088298570283 0.9161377239768662 1.2209526103961694 0.9654310703435655 1.031014686215957 1.0155744502619297 1.0168486498249796 1.0 12.282663343315768 LQQGAGLES(ph)PQGQPEPGAAS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 LQQGAGLESPQGQPEPGAASPQR 23 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 2 LQQGAGLES(1)PQGQPEPGAAS(1)PQR;LQQGAGLES(1)PQGQPEPGAAS(1)PQR 141.17 9.3293e-06 49150000.0 41725.0 36769.0 47289.0 54826.0 56877.0 34960.0 38251.0 38137.0 37567.0 47500.0 True False 39406.091538409084 39589.06406903069 44246.47722437021 47358.60421987472 49731.602773168575 39775.422664717495 40029.74729291857 38247.9723560798 45081.44970968131 46128.5515801786 0.8542668301629884 0.8582334088729999 0.9591993615377874 1.0266657546694933 1.078108916702648 0.8622733925556196 0.8677867811075888 0.8291604883712612 0.977300352284479 1.0 15.493372372562169 -10.522309248532418 0.00522244695782245 1.8992923336998273 2.596937687300167e-06 0.04415366086011385 0.08107357816748148 129957.21786051805 129.2343948902348 24235.053082491693 22776.918136869266 3.003936524614061e-11 10.522309248532418 -1.89928973676214 LQQGAGLESPQGQPEPGAAS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 LQQGAGLESPQGQPEPGAASPQR 23 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 LQQGAGLESPQGQPEPGAAS(1)PQR;LQQGAGLESPQGQPEPGAAS(1)PQR 161.04 6.3514e-10 55301000.0 7021.0 7714.2 6909.2 7547.4 7220.9 6796.2 7686.8 6931.0 4516.4 6337.299999999999 True False 7184.5756395121725 6811.017877765717 5970.968589518969 6229.388272244573 6567.770869953439 6727.836398455879 7106.978487321817 6747.16736493908 7664.000935195219 7150.754185529421 1.004729774385364 0.9524894439175088 0.8350124245079046 0.871151225537949 0.918472471511364 0.9408568975941899 0.993878170459811 0.943560244119836 1.0717751913084115 1.0 12.803879694712933 -7.4709307439097925 1.1757173827252376 1.018799299458709 0.9118679306156227 0.40264663151060787 0.05051179706156219 0.5343118402610757 1.3898651708437941 0.04030127576865121 0.01934722100493598 3.381187510418446e-08 7.4709307439097925 -0.1069313688430863 LQQGAGLESPQGQPEPGAAS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 LQQGAGLESPQGQPEPGAASPQR 23 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 LQQGAGLESPQGQPEPGAAS(1)PQR;LQQGAGLES(0.001)PQGQPEPGAAS(0.999)PQR 106.36 1.3465e-05 143408000.0 157983.0 177250.0 187012.0 243900.0 222643.0 167907.0 144137.0 146473.0 153345.0 184316.0 True False 149202.93731605695 190844.50505142024 174979.85152327036 210680.39924903234 194672.59588632607 191034.66514201128 150839.6561020471 146899.21218008955 184018.28481728866 178994.31816952006 0.8335624216560404 1.0662042628117236 0.9775721001241631 1.1770228318057747 1.0875909239865234 1.0672666434086928 0.8427063922732534 0.8206920402968646 1.028067743709108 1.0 17.449554267072955 -7.250369196993945 24.356874421097302 0.9079242127663508 1.0425476270887057 0.21729819396240513 0.10195833691024431 684.4784808021611 1506007.5330468053 0.0395507985519966 0.030317550833108713 5.618634777548823e-08 7.250369196993945 0.13462341432235492 LQQQAALSPT(ph)TAPAVSSVSK ddPTM_A459_Selumetinib_30min_R1 1 LQQQAALSPTTAPAVSSVSK 20 0 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LQQQAALS(0.335)PT(0.504)T(0.156)APAVS(0.003)S(0.001)VSK 78.554 0.011329 16108000.0 3572.1 3842.4 4857.1 4712.6 3775.2 3359.1 4425.7 3694.7 2136.0 3572.3 True False 3655.3229799033484 3392.5300217167032 4197.532498140536 3889.632876458091 3433.733826565693 3325.3105038187705 4091.865885848489 3596.7045539230144 3624.6359927324847 4030.83950214867 0.906839128165448 0.8416435385006744 1.0413544116313758 0.9649684326018667 0.8518656782874423 0.8249672312792876 1.0151398694161076 0.8922966424254212 0.8992260770492957 1.0 11.976864624520893 -10.9480540080249 5.486125799682267 1.0000589166850609 0.9160923185962332 0.12099613142694243 0.06840882498504043 5.0635952743146006e-05 5.30549325604721e-06 0.06803557067192494 0.016489480373969127 1.1270572887875803e-11 10.9480540080249 -0.08396659808882767 LQQQAALSPT(ph)TAPAVSSVSK ddPTM_A459_Selumetinib_30min_R2 3 LQQQAALSPTTAPAVSSVSK 20 0 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LQQQAALS(0.122)PT(0.439)T(0.439)APAVSSVSK;LQQQAALS(0.231)PT(0.383)T(0.383)APAVS(0.001)S(0.001)VSK;LQQQAALS(0.101)PT(0.685)T(0.213)APAVSSVSK 169.62 5.1136e-09 30477400.0 159611.0 156189.0 173126.0 189538.0 191973.0 133150.0 138626.0 157177.0 133717.0 160267.0 True False 150740.45959345743 168168.19407320936 161987.2616453368 163722.59742871244 167855.63547960515 151490.20388464327 145072.38368220776 157634.35904794693 160464.13636514632 155639.67528632615 0.968522064288198 1.0804969476056463 1.0407838576335575 1.0519335582493112 1.0784887283451705 0.9733392440324152 0.9321041271470271 1.0128160365147976 1.0309976300705121 1.0 17.247850349944414 -6.772627823073745 24.999904426153137 0.9870431972320107 1.0463272146294103 0.3374424690289457 0.037799405249900005 244.12273074816184 545474.1514946651 0.013464991173989372 0.011983821143728396 1.6879989685955738e-07 6.772627823073745 0.059284017397399524 LQQQAALSPTT(ph)APAVSSVSK ddPTM_A459_Selumetinib_30min_R2 1 LQQQAALSPTTAPAVSSVSK 20 0 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LQQQAALS(0.278)PT(0.278)T(0.439)APAVS(0.003)S(0.002)VSK 105.38 0.0011639 21625000.0 71010.0 73803.0 94250.0 81039.0 89429.0 69522.0 71137.0 71830.0 68860.0 79277.0 True False 67063.54847555252 79463.45278595209 88186.0576116412 70001.3483999275 78194.12951459619 79098.02444211928 74445.01145529142 72039.01340790342 82633.92410915578 76988.06702361708 0.8710901710907992 1.032152849890044 1.1454509902760512 0.9092493305287648 1.0156655769862248 1.0274062916510807 0.9669681852442723 0.9357166141839166 1.073334184163979 1.0 16.232347228214458 -7.26347163012273 24.558747689628632 0.9886478018760491 1.0047983791031818 0.0 0.07664236170367845 1192.577429757401 14411642.919146841 0.030959208045196696 0.022259454662766937 5.4516550694813536e-08 7.26347163012273 0.016150577227132756 LQQQHSEQPPLQPS(ph)PVMTR ddPTM_A459_Selumetinib_30min_R1 2 LQQQHSEQPPLQPSPVMTR 19 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;Q5JTV8-2;H0YDU3 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 LQQQHSEQPPLQPS(0.855)PVMT(0.145)R;LQQQHSEQPPLQPS(0.979)PVMT(0.021)R 120.44 0.00028844 16259000.0 1692.38 2533.28 2312.94 1996.32 2074.66 2373.54 2474.98 2083.0 1149.44 1958.5299999999997 True False 1731.8091612017668 2236.6823999100798 1998.8554520699934 1647.7001875675453 1887.0073693109723 2349.6643426018895 2288.2902659821702 2027.75207346243 1950.5157282239825 2209.926403197723 0.7836501517407415 1.0121071890329203 0.9044896016345549 0.7455905251791884 0.8538779239799602 1.0632319425669416 1.0354599423180137 0.9175654313774023 0.8826156949849651 1.0 11.109782609251798 -6.734064172143138 24.91991643477487 0.9781027971101479 0.8645184725221242 0.3448503500056691 0.08244741459623027 281.1075369631981 255894.1998364837 0.029097728860513376 0.029090913957412298 1.8447428164835158e-07 6.734064172143138 -0.1135843245880237 LQQQHSEQPPLQPS(ph)PVMTR ddPTM_A459_Selumetinib_30min_R2 4 LQQQHSEQPPLQPSPVMTR 19 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;Q5JTV8-2;H0YDU3 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 LQQQHSEQPPLQPS(0.962)PVMT(0.038)R;LQQQHSEQPPLQPS(0.979)PVMT(0.021)R;LQQQHSEQPPLQPS(0.986)PVMT(0.014)R;LQQQHSEQPPLQPS(0.991)PVMT(0.009)R 136.96 0.00011105 79146600.0 189170.0 92288.0 157376.0 192039.0 126832.0 97718.0 238236.0 158329.0 146092.0 114766.0 True False 178656.68870750978 99366.19284730883 147250.59949803338 165882.95691424736 110898.23026753368 111177.76750431527 249314.44605567833 158789.71117722307 175314.48215153665 111452.40738212179 1.602986358966422 0.8915571693900286 1.3211971186335632 1.4883748212410246 0.995027679279389 0.9975358102686387 2.2369588231583695 1.4247311018846123 1.572998612317629 1.0 16.76606825371495 LQQQHSEQPPLQPSPVMT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 LQQQHSEQPPLQPSPVMTR 19 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;Q5JTV8-2;H0YDU3 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 LQQQHSEQPPLQPS(0.347)PVMT(0.653)R 69.27 0.024196 35396000.0 58163.0 27854.0 50381.0 54329.0 35708.0 33121.0 66187.0 44725.0 53091.0 38078.0 True False 54930.533304936784 29990.312235273763 47139.54131068527 46929.296477247495 31222.04180642971 37683.117107497375 69264.82664705237 44855.14234537768 63710.68348648252 36978.58920147453 1.485468604701296 0.8110182914733234 1.274779333896426 1.269093751023259 0.8443275549621216 1.019052319767644 1.8731062526390383 1.2130030732375552 1.722907359698353 1.0 15.174402563976198 -7.215283809954508 24.999093559219414 1.4700052663470722 1.105019862438793 0.2337421016703205 0.2959176919274362 552.1817798055102 299076.65276835795 0.10617726092271512 0.08224426893955182 6.091386970936194e-08 7.215283809954508 -0.36498540390827916 LQQTVPADAS(ph)PDSK ddPTM_A459_Selumetinib_30min_R1 1 LQQTVPADASPDSK 14 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 LQQTVPADAS(0.5)PDS(0.5)K 209.6 5.053e-06 22678000.0 3831.8 5126.6 3076.7 3360.6 3286.2 3057.5 4199.3 3902.6 2110.7 3952.0 True False 3921.073484615118 4526.375288708319 2658.9010391033707 2773.734296274892 2988.963790225731 3026.7443259878823 3882.543420124174 3799.090370568642 3581.7037405713722 4459.27769573987 0.8793068636118087 1.0150467402002235 0.5962627179831226 0.6220142555653696 0.6702798063195773 0.6787521505735009 0.8706664363677836 0.8519519594390966 0.8032026675515453 1.0 12.122594329075547 -8.612533607922774 0.8000960451727669 0.9933659703110401 0.7509165079701549 0.2421635713375624 0.12462328467397893 1.2369279497111052 1.7317639441023618 0.13492606586778566 0.048962712478131026 2.4404302077940685e-09 8.612533607922774 -0.24244946234088527 LQQTVPADAS(ph)PDSK ddPTM_A459_Selumetinib_30min_R2 3 LQQTVPADASPDSK 14 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 LQQT(0.004)VPADAS(0.99)PDS(0.006)K;LQQT(0.002)VPADAS(0.971)PDS(0.027)K;LQQT(0.002)VPADAS(0.926)PDS(0.072)K 146.67 0.0004934000000000001 99143000.0 473750.0 421930.0 459340.0 475310.0 464960.0 407091.0 488520.0 479450.0 378760.0 438924.0 True False 447420.87157151155 454290.6742812176 429786.5644915781 410571.9580445165 406547.56800486054 463164.0900458379 511237.1479840155 480845.1201227793 454522.58343862643 426251.12365849066 1.0496649668189073 1.065781763534287 1.008294267479562 0.9632161307179657 0.9537747713495379 1.0865991063449294 1.1993801766341268 1.128079419464543 1.0663258305045236 1.0 18.70134411172763 -6.932122466463006 7.248109376718596 1.1138404751028346 1.009356724379881 0.36037572650358274 0.05725533572779447 0.22584882733880884 20.11310752713232 0.020991753241422082 0.01848536955894654 1.1691696510211418e-07 6.932122466463006 -0.10448375072295346 LQQTVPADAS(ph)PDSKCPICLDR ddPTM_A459_Selumetinib_30min_R2 1 LQQTVPADASPDSKCPICLDR 21 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 LQQT(0.121)VPADAS(0.875)PDS(0.004)KCPICLDR 54.441 0.019233 8134700.0 40541.0 44211.0 35414.0 49803.0 42543.0 22164.0 24546.0 25997.0 20873.0 42971.0 True False 38287.89351848154 47601.84153922913 33135.5017958478 43019.745485032996 37198.368000754446 25216.889815240243 25687.437636976283 26072.646965964977 25048.18324034865 41730.31557793378 0.9175078833750174 1.1407016908446315 0.7940390897347835 1.030899117086501 0.8913991539624074 0.6042822697601278 0.6155581926765807 0.6247891156555669 0.6002394876111041 1.0 15.34880821031128 -6.641905146587689 4.585820914891158 0.6617215484823137 0.9692487660661686 0.479167411027965 0.13876350249449715 0.16438043858418508 5.852345871931456 0.04418381202798897 0.04395368987325434 2.2808401714654965e-07 6.641905146587689 0.30752721758385493 LQQTVPADASPDS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 LQQTVPADASPDSK 14 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 LQQTVPADAS(0.315)PDS(0.685)K 125.33 0.0013880999999999998 22447000.0 7143.7 9168.5 6086.9 6304.1 6481.8 6425.4 7400.9 7221.0 3694.5 7153.4 True False 7310.134310779531 8095.047757679988 5260.332412948389 5203.207277613087 5895.522334454735 6360.766309796416 6842.644154501225 7029.47562288632 6269.296664396143 8071.60857001659 0.9056601602231197 1.0029039053938351 0.6517080662817099 0.6446307737148349 0.7304024078118319 0.7880419689112033 0.8477423174259751 0.8708890628069531 0.7767096991898923 1.0 12.978640497784689 -10.106636925933516 8.04062545250155 1.000000723565632 0.7997756604231931 0.24030693968231198 0.10550205777825704 0.0 0.0 0.11263673470361933 0.027318420853393942 7.822815256355976e-11 10.106636925933516 -0.20022506314243893 LQS(ph)EPESIR ddPTM_A459_Selumetinib_30min_R1 2 LQSEPESIR 9 0 P09496-2;F8WF69;P09496-4;P09496-3;P09496 P09496-2 CLTA Clathrin light chain A 1 LQS(1)EPESIR;LQS(1)EPESIR 119.74 0.006799899999999999 13212900.0 3390.8 4641.5 3790.8999999999996 4095.3 4064.5 3707.3999999999996 3775.2 3883.0 2309.0 3162.7 True False 3469.7990426517413 4098.071022225193 3276.1166019231528 3380.132733301958 3696.8666926457604 3670.106922049869 3490.433624569041 3780.010226238413 3918.2043573124092 3568.6633523068035 0.9722965435809025 1.1483490084813344 0.9180234386091513 0.9471705228561337 1.0359247504408298 1.028426208843009 0.9780787034206535 1.0592229787645824 1.0979473182248083 1.0 11.801168096706085 -7.782612643159383 24.176387493068503 1.0589389332845618 1.006257753069946 0.10659514414683646 0.06307221892495932 375.3674784806872 428598.94255457644 0.03450309671080083 0.016605397847681946 1.6496330797374172e-08 7.782612643159383 -0.052681180214615875 LQS(ph)EPESIR ddPTM_A459_Selumetinib_30min_R2 1 LQSEPESIR 9 0 P09496-2;F8WF69;P09496-4;P09496-3;P09496 P09496-2 CLTA Clathrin light chain A 1 LQS(0.995)EPES(0.005)IR 106.26 0.013272 6521700.0 20331.0 15004.0 26597.0 23697.0 18634.0 19043.0 18511.0 19017.0 17937.0 19252.0 True False 19201.084411441454 16154.758554536056 24885.77797662406 20469.427720394884 16293.030329926394 21666.000394857412 19371.798178850644 19072.336321566174 21524.901201654462 18696.144737296807 1.0270076896194191 0.8640689715195156 1.3310646834574187 1.0948475211341602 0.871464708840403 1.1588485593843345 1.0361386505639305 1.020121345312379 1.1513015920717917 1.0 14.190453187534006 LQS(ph)EPESIRK ddPTM_A459_Selumetinib_30min_R1 1 LQSEPESIRK 10 1 P09496-2;F8WF69;P09496-4;P09496-3;P09496 P09496-2 CLTA Clathrin light chain A 1 LQS(0.997)EPES(0.003)IRK 99.539 0.033017000000000005 9021200.0 2925.9 2818.5 2778.2 3064.9 2580.2 2375.3 2379.0 2305.3 1428.5 1610.5 True False 2994.0677771896667 2488.5087097149 2400.9356995602366 2529.672750298434 2346.8213655713075 2351.4066385998417 2199.550114656113 2244.155955330265 2424.060166487991 1817.2233625984456 1.647605813799605 1.369401671215906 1.3212111119500143 1.3920538346377287 1.2914325304598717 1.2939557607478522 1.210390621167768 1.2349367730565322 1.3339362768382144 1.0 10.827520042873683 -1.5228787452803376 0.09812957685352888 0.8892836467699895 2.6722020257118277 0.7267345465162232 0.08050892896454229 74.93380628198713 0.5245848695584581 1.11432733098662 17.976252443615067 0.029999999999999995 1.5228787452803376 1.7829183789418384 LQS(ph)PIKEENTTAVEEIGR ddPTM_A459_Selumetinib_30min_R1 2 LQSPIKEENTTAVEEIGR 18 1 S4R3Y0;S4R3P6;S4R3N2;A0A087X1L0;S4R2X9;Q9NS73-3;Q9NS73-2;Q9NS73-5;Q9NS73 S4R3Y0 MBIP MAP3K12-binding inhibitory protein 1 1 LQS(0.937)PIKEENT(0.031)T(0.031)AVEEIGR;LQS(0.995)PIKEENT(0.002)T(0.002)AVEEIGR 69.935 0.013558 36837000.0 4166.4 4300.8 4290.1 4916.6 4526.4 3548.8 4011.3 3654.4 2200.8999999999996 3386.6 True False 4263.469013596852 3797.2603366123244 3707.5279838324723 4058.008106012356 4116.987919200827 3513.1022940525913 3708.7244114838427 3557.4734408358636 3734.7665526240257 3821.30309827749 1.1157107677531979 0.9937082296151795 0.9702260952562743 1.0619435312110062 1.0773780077944146 0.9193466740798906 0.9705391894078244 0.9309581965480437 0.9773541790776891 1.0 11.899848978641035 -6.762621666209374 24.999996681475544 0.9560057556062234 1.0379320979720326 0.47512597125816236 0.04392681980018966 30.224375939564407 639098.5034140336 0.015326885332095416 0.014273919311317385 1.727342003383909e-07 6.762621666209374 0.0819263423658092 LQS(ph)PIKEENTTAVEEIGR ddPTM_A459_Selumetinib_30min_R2 2 LQSPIKEENTTAVEEIGR 18 1 S4R3Y0;S4R3P6;S4R3N2;A0A087X1L0;S4R2X9;Q9NS73-3;Q9NS73-2;Q9NS73-5;Q9NS73 S4R3Y0 MBIP MAP3K12-binding inhibitory protein 1 1 LQS(0.937)PIKEENT(0.046)T(0.017)AVEEIGR;LQS(0.807)PIKEENT(0.097)T(0.097)AVEEIGR 55.18899999999999 0.037655 16509200.0 51242.0 55157.0 47826.0 59511.0 46328.0 36943.0 48782.0 39946.0 34477.0 53336.0 True False 48394.17477797862 59387.364542291776 44748.9272290116 51405.4991377989 40507.862462425095 42031.56291483576 51050.4596596992 40062.236246583685 41373.36336786759 51796.05109642955 0.9343217051022363 1.1465616255519044 0.8639447657062078 0.9924598120829027 0.7820646864953266 0.8114819957333217 0.9856052455554521 0.7734612079210279 0.7987744720315092 1.0 15.660554491346161 -5.651788188264221 1.585994754902074 0.8565955763020678 1.0325402094531533 0.25484203655606563 0.10080320291463615 0.48536708163588616 2.422505641067513 0.030571393279232143 0.07796459021915142 2.2295222545829065e-06 5.651788188264221 0.17594463315108544 LQS(ph)PLPGESAAK ddPTM_A459_Selumetinib_30min_R2 4 LQSPLPGESAAK 12 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 LQS(1)PLPGESAAK;LQS(0.999)PLPGES(0.001)AAK;LQS(1)PLPGESAAK;LQS(0.996)PLPGES(0.004)AAK 127.03 0.0026515 102651800.0 300015.0 285545.0 305590.0 325741.0 339442.0 235367.0 267680.0 269529.0 212857.0 271766.0 True False 283341.367355202 307445.38332811167 285928.6721012342 281374.513865433 296798.26131001755 267786.6678011028 280127.6503978574 270313.2847670721 255434.34772150067 263919.40944713325 1.073590487144369 1.164921458304859 1.083393876563329 1.066138009534294 1.1245791354707861 1.0146531790218491 1.0614135996464895 1.024226620290387 0.9678498002727145 1.0 18.00973792924433 -7.186152615416384 0.6575724640356143 0.9856881680721106 1.113283546266551 0.6191255714137016 0.03455014086269633 0.4855145525406156 0.42681215655945237 0.0289790144578008 0.021074245301611522 6.513994455678899e-08 7.186152615416384 0.12759537819444033 LQS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 LQSPSR 6 0 Q96A00-2;Q96A00;K7EJB8;K7EMN0 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 LQS(0.977)PS(0.023)R 112.41 0.025076 72133000.0 4566.1 6154.1 6672.7 4723.4 4734.8 5346.8 3942.2 5038.8 5702.8 4736.4 True False 4672.4812459160385 5433.575111036527 5766.583990517459 3898.5468591991958 4306.538175996837 5293.01604650597 3644.8366801165716 4905.154655670905 9677.2350839676 5344.363076442892 0.8742821509473407 1.0166927346285413 1.0790030370383423 0.7294689382881516 0.8058094321808668 0.9903923013458327 0.6819964564500559 0.9178183790117203 1.8107368353440139 1.0 12.383802307217765 -8.13433421415625 9.033660340859575 1.4033239873598082 0.8842925165804371 0.48011563374514765 0.2160214876228782 0.24586680883133674 16.587392821663997 0.13702526843100912 0.051602395748822326 7.339488356506405e-09 8.13433421415625 -0.5190314707793712 LQS(ph)SQEPEAPPPR ddPTM_A459_Selumetinib_30min_R2 1 LQSSQEPEAPPPR 13 0 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 LQS(0.5)S(0.5)QEPEAPPPR 186.29 0.00013209 6446900.0 22205.0 14057.0 20130.0 20075.0 21022.0 16980.0 16404.0 20159.0 12638.0 17335.0 True False 20970.934993657836 15135.12669962099 18834.85771588684 17340.750368693403 18381.02842093552 19318.840870906828 17166.818503909355 20217.659352497903 15165.953135223797 16834.49350826095 1.2457122623479624 0.8990544736135925 1.1188253276906892 1.0300725923345435 1.0918670295554576 1.1475748207943868 1.0197407183937743 1.2009662983075065 0.9008856208107255 1.0 14.039132695659328 -8.279965056941311 24.929972014952966 0.9504428010053244 1.0856191898744887 0.26294582163531466 0.09542461242153076 1225.741688362727 1649461.869422283 0.08382877424548373 0.021800167706501623 5.248496876240889e-09 8.279965056941311 0.13517638886916428 LQSFDS(ph)PER ddPTM_A459_Selumetinib_30min_R1 3 LQSFDSPER 9 0 E9PGM9;P78332;P78332-2 E9PGM9 RBM6 RNA-binding protein 6 1 LQSFDS(1)PER;LQS(0.003)FDS(0.997)PER;LQSFDS(1)PER 151.13 0.0012465 90021100.0 10030.7 10757.7 10051.599999999999 10909.9 10369.1 8780.2 9281.2 8529.0 4856.0 7929.5 True False 10264.395793655423 9498.183482880955 8686.64792948661 9004.690769186876 9431.216735813296 8691.879159783744 8581.111611663016 8302.783213903534 8240.277331792571 8947.328564870779 1.1472022871671157 1.0615664121437272 0.9708649756746768 1.0064110984524828 1.0540818600137667 0.9714496451946577 0.9590696876109354 0.9279622575281438 0.9209762748789343 1.0 13.127241280835994 -1.522878745280452 0.46283080439070295 0.9570874656253201 5.510923513795834 0.7023585774793029 0.03584159255131998 55.65718443864142 0.6508490964729968 0.023728711041563925 241.43039621541666 0.029999999999992095 1.522878745280452 4.553836048170514 LQSFDS(ph)PER ddPTM_A459_Selumetinib_30min_R2 4 LQSFDSPER 9 0 E9PGM9;P78332;P78332-2 E9PGM9 RBM6 RNA-binding protein 6 1 LQSFDS(1)PER;LQSFDS(1)PER;LQS(0.001)FDS(0.999)PER;LQSFDS(1)PER 152.96 0.0010517 105892400.0 125391.0 113775.0 136564.0 137621.0 142390.0 110458.0 103694.0 119138.0 105331.0 119247.0 True False 118422.27019994386 122501.17665571478 127777.6209196409 118876.78239053338 124501.69521724911 125672.58686211008 108515.97646576299 119484.67185564234 126400.1431940386 115804.0292690852 1.022609238619624 1.0578317302852038 1.1033952939818146 1.026534077793686 1.0751067644455945 1.0852177394457843 0.9370656370998327 1.0317833723903054 1.0915003907189793 1.0 16.821325925565326 LQSIGTENTEENR ddPTM_A459_Selumetinib_30min_R1 2 LQSIGTENTEENR 13 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 297.18 1.1693999999999992e-72 21079900.0 2351.9900000000002 2290.69 1965.1299999999999 2134.6099999999997 2232.25 2348.75 2182.99 2006.51 1272.4 1966.79 False True 2406.7867908241324 2022.4949498871108 1698.27613968642 1761.840435092349 2030.3433816357472 2325.1237074943715 2018.3253067646667 1953.2908367369666 2159.1698675809057 2219.246654656938 1.0845062155545686 0.9113430206791313 0.7652489353189755 0.7938912204261959 0.9148795503984245 1.047708555790884 0.9094641654767615 0.8801594147446922 0.9729291978654264 1.0 11.115854307165282 -6.52424131067591 24.999897681131916 0.9546108719343441 0.8781456770421263 0.12188845705276286 0.09065063737428285 102.94000253466497 1888648.4448536213 0.03180432859214558 0.03204496522342371 2.9906024813988324e-07 6.52424131067591 -0.07646519489221781 LQSIGTENTEENR ddPTM_A459_Selumetinib_30min_R2 2 LQSIGTENTEENR 13 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 265.53 2.3765e-29 19477800.0 27422.0 21810.4 29859.0 31415.0 29687.0 20717.5 25939.0 20392.9 23529.0 24428.0 False True 25897.99501896354 23483.187548510617 27937.904448021116 27136.222806102276 25957.453654852667 23571.147570259865 27145.214897153404 20452.239962773674 28235.457455189167 23722.700168433745 1.0916967644949758 0.9899036526945684 1.177686530186655 1.1438926687700872 1.0942031670320802 0.9936114945980922 1.1442717188355218 0.8621379445661983 1.1902294955765724 1.0 14.533980609412385 -6.645625108311104 8.26299289070085 1.03620383685902 1.1008568607451492 0.09594265120012635 0.09433088209575308 0.6051456977510253 41.300980290479714 0.029830679861741833 0.029800441141776785 2.2613870024491395e-07 6.645625108311104 0.06465302388612915 LQSIGTENTEENRR ddPTM_A459_Selumetinib_30min_R1 2 LQSIGTENTEENRR 14 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 149.35 0.00059797 159162000.0 7293.6 5660.6 8940.0 9448.2 8953.1 8625.4 7773.7 8465.8 5374.6 7182.5 False True 7463.526689124903 4997.854320458455 7725.997103904876 7798.249234679646 8143.293685798186 8538.636307236591 7187.323550358225 8241.259483206066 9120.303654747193 8104.443838474599 0.9209178122369063 0.6166807272735868 0.9533037994818219 0.9622189245927844 1.0047936475466894 1.053574616274189 0.8868373565916409 1.0168815587421256 1.1253460245414937 1.0 12.984497469910755 -5.43920381907617 6.654270989650748 1.0013123136974353 0.7692807978305283 0.525802476145323 0.08909109024124956 0.17589074660763013 11.694176821182777 0.022427534514507602 0.046980880351666435 3.6374428695302435e-06 5.43920381907617 -0.23203151586690707 LQSIGTENTEENRR ddPTM_A459_Selumetinib_30min_R2 4 LQSIGTENTEENRR 14 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;;; 156.2 0.00043655 224437000.0 367304.0 331717.0 392680.0 442587.0 437724.0 340197.0 339073.0 343265.0 294739.0 403097.0 False True 346890.7141144113 357158.6272617326 367415.3963176579 382305.887094839 382733.19781779003 387056.0487491104 354840.566360403 344263.84431942034 353695.0356957369 391458.5422382165 0.8861493023782732 0.9123791889164825 0.9385806073279467 0.9766190946018295 0.9777106807516879 0.9887536149704788 0.9064575889225834 0.8794388349556657 0.9035312747895046 1.0 18.578500000153937 -5.054854607007012 2.4937253420217362 0.944477922264351 0.8865592218054765 0.20988573043645298 0.03816533058713901 0.6213912099929124 6.827856959593361 0.011418492023414845 0.059045485914410084 8.813438796975067e-06 5.054854607007012 -0.057918700458874484 LQSS(ph)LESEVSVLASK ddPTM_A459_Selumetinib_30min_R2 1 LQSSLESEVSVLASK 15 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 LQS(0.16)S(0.656)LES(0.182)EVS(0.003)VLASK 100.77 0.011119 0.0 5422.9 5525.8 5370.7 4973.7 6772.3 3151.1 4090.8 4536.0 3174.2 4420.4 True False 5121.516927588702 5949.611091752558 5025.155009176028 4296.273479888936 5921.503128869832 3585.1354221622237 4281.030305766419 4549.199009024773 3809.1286945582647 4292.771566421502 1.1930560124954541 1.3859603288213667 1.1706085291104946 1.0008157698151996 1.3794125863086764 0.8351563475227798 0.997264876438587 1.0597347048720394 0.8873355210311349 1.0 12.067693688577746 -6.257310514657002 0.6982349585584264 0.9584160320319464 1.2931591005841976 0.4068336867601813 0.13778337460832085 0.8111163889091142 0.8460910646066664 0.08478545758060965 0.15584134266271238 5.529546128060674e-07 6.257310514657002 0.3347430685522512 LQSS(ph)QEPEAPPPR ddPTM_A459_Selumetinib_30min_R1 1 LQSSQEPEAPPPR 13 0 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 LQS(0.068)S(0.932)QEPEAPPPR 109.95 0.006902500000000001 0.0 1209.7 1509.4 1214.0 1278.0 1289.4 1291.2 1568.0 1293.0 762.78 1647.6 True False 1237.8836563335533 1332.678746298977 1049.1454680246663 1054.821291031159 1172.773997662059 1278.2117003157982 1449.7244975959568 1258.7054397440825 1294.3819487530352 1859.0855089830488 0.6658562235852704 0.7168463956388832 0.5643341648112606 0.5673871836095178 0.6308338115677025 0.6875486329916054 0.779805173345136 0.677056237414607 0.6962465914013196 1.0 10.860377413471763 -10.89735446732705 0.29227910309316874 1.244804683306158 0.6240765585572747 0.7707146280640611 0.05650881347015166 10.199519600000736 0.6124382024387899 1.9550439872173373 0.07265418549105875 1.2666176417012748e-11 10.89735446732705 -0.6207281247488832 LQSS(ph)QEPEAPPPR ddPTM_A459_Selumetinib_30min_R2 1 LQSSQEPEAPPPR 13 0 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 LQS(0.347)S(0.653)QEPEAPPPR 175.6 9.893e-05 7010600.0 21068.0 19671.0 20100.0 26396.0 23592.0 18314.0 22576.0 18672.0 17350.0 22668.0 True False 19897.124901886225 21179.702447765845 18806.787883225305 22800.81926436019 20628.16204484401 20836.58726206053 23625.828733495335 18726.332428684007 20820.48479950411 22013.515941462894 0.9038594722803728 0.9621226570115251 0.8543291282153773 1.0357645423380277 0.937068031281203 0.9465360879864904 1.0732419480976965 0.8506743074790969 0.9458046072635 1.0 14.426101966678658 -5.753364720209772 24.999878306398884 0.9656162081416008 0.9123056715505502 0.17501104353909858 0.061954732646758374 377.67205901881965 1169294.1393612484 0.016724522521575965 0.028319423629619516 1.7645553259147296e-06 5.753364720209772 -0.05331053659105056 LQT(ph)PNTFPK ddPTM_A459_Selumetinib_30min_R2 1 LQTPNTFPK 9 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 LQT(0.962)PNT(0.038)FPK 118.9 0.016525 2638900.0 32477.0 35835.0 35027.0 38596.0 44700.0 27499.0 36560.0 37148.0 33124.0 41348.0 True False 30672.058355731857 38583.42927231403 32773.40095451408 33339.15821818632 39084.38637692975 31286.73763893211 38260.11244226564 37256.09452981753 39749.725561889 40154.1758049942 0.7638572512280778 0.9608821124779554 0.8161891085419283 0.830278733153321 0.973357953273408 0.7791652303081466 0.9528302268753582 0.9278261546382874 0.9899275670587939 1.0 15.293262407139952 -7.790041560534207 1.1892067868306793 0.9982688455057861 0.8604903031778177 0.39178753008657563 0.06788014346872488 0.5138688890228261 1.3154774368378181 0.05529850924509282 0.021289028454518494 1.6216549029647924e-08 7.790041560534207 -0.13777854232796838 LQTICLS(ph)GTGMK ddPTM_A459_Selumetinib_30min_R1 1 LQTICLSGTGMK 12 0 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 LQTICLS(0.987)GT(0.013)GMK 116.9 0.0048978 10433000.0 1394.6 1531.8 1744.3 1843.9 1434.9 1328.2 1599.4 1841.8 916.88 1257.3 True False 1427.091466580783 1352.4561438854992 1507.433640754058 1521.8974792897905 1305.1135483521703 1314.8395139091099 1478.7559703156721 1792.949480990449 1555.8783937343449 1418.686702139103 1.0059243273578353 0.9533155853552858 1.0625556992119132 1.0727509301349378 0.9199448661810344 0.9268004781651848 1.0423414613571809 1.2638093232896528 1.096703304111037 1.0 10.470340309455281 -7.534142903864114 24.854979789484002 1.1387689157610428 0.9917326880397067 0.35614679309152597 0.07699886057301233 199.95996828401306 441216.2420641229 0.03586326738258778 0.020728084267213474 2.923190348738996e-08 7.534142903864114 -0.14703622772133607 LQTLS(ph)PSHK ddPTM_A459_Selumetinib_30min_R2 2 LQTLSPSHK 9 0 H0YAP0;Q96GY0 H0YAP0 ZC2HC1A Zinc finger C2HC domain-containing protein 1A 1 LQT(0.003)LS(0.888)PS(0.108)HK;LQTLS(0.987)PS(0.013)HK 109.72 0.0077495 13110000.0 74905.0 74372.0 91996.0 74768.0 88130.0 66112.0 57705.0 72566.0 40635.0 87974.0 True False 70742.07996847286 80076.09325632859 86077.07751767145 64584.469418005865 77058.32150780356 75218.32789501717 60388.396840288246 72777.15504605201 48763.13543676367 85433.9620360974 0.8280322986610763 0.9372864297513791 1.0075276326445253 0.7559577933505853 0.9019635712931705 0.8804265435241792 0.7068429861039695 0.8518527446415554 0.5707699171924201 1.0 16.382522069079705 -7.178877987607692 7.840792552998679 0.7702093234879231 0.8884582355517137 0.1490710554586887 0.11885079078708591 0.5081966814822364 43.407578642804545 0.04319530259462487 0.033413322238877316 6.624025755359974e-08 7.178877987607692 0.11824891206379051 LQTLSPS(ph)HK ddPTM_A459_Selumetinib_30min_R2 1 LQTLSPSHK 9 0 H0YAP0;Q96GY0 H0YAP0 ZC2HC1A Zinc finger C2HC domain-containing protein 1A 1 LQT(0.001)LS(0.219)PS(0.78)HK 87.719 0.021265 7574600.0 72704.0 71556.0 71766.0 78754.0 77832.0 59926.0 64548.0 54867.0 57466.0 85979.0 True False 68663.40273717177 77044.11511119566 67148.65369291267 68027.5693417723 68054.04833309175 68180.26254593431 67549.60989943554 55026.65388627917 68960.80573419626 83496.56286972984 0.8223500510350281 0.9227219955317059 0.8042085971571915 0.8147349663711062 0.8150520930935651 0.8165637027755046 0.809010665562671 0.65902897071501 0.8259119101918954 1.0 16.349429189916293 -5.296569617489151 22.974621716655413 0.8052829393267955 0.8725360186642475 0.05020352164442188 0.08068138572225193 451.98551633052193 295590.6742518094 0.02021768741583577 0.04209173584572884 5.051616609378451e-06 5.296569617489151 0.06725307933745195 LQTPNT(ph)FPK ddPTM_A459_Selumetinib_30min_R1 2 LQTPNTFPK 9 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 LQT(0.042)PNT(0.958)FPK;LQT(0.035)PNT(0.965)FPK 122.33 0.013985 52388000.0 5796.799999999999 6792.1 7630.400000000001 8217.5 6331.1 6238.1 6041.1 5372.3 3811.1000000000004 5142.0 True False 5931.854161390704 5996.877774438374 6594.233590787001 6782.467886579455 5758.45312284649 6175.350377741625 5585.414963282485 5229.809152310236 6467.158348269086 5802.0257873214605 1.022376386942806 1.033583440380893 1.1365398625419187 1.1689827200355518 0.9924900946544938 1.0643438350853163 0.9626663458627999 0.9013764061060142 1.114637987718198 1.0 12.502340992324525 -6.299574804963704 24.89367132382212 1.00174651134308 1.0896122115492486 0.2764756572687874 0.06671943166838466 713.1742561448259 465537.15708741755 0.0214681513696125 0.024343255202354627 5.016781601428177e-07 6.299574804963704 0.08786570020616868 LQTPNT(ph)FPK ddPTM_A459_Selumetinib_30min_R2 3 LQTPNTFPK 9 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 LQT(0.1)PNT(0.9)FPK;LQT(0.302)PNT(0.698)FPK;LQT(0.065)PNT(0.935)FPK 112.94 0.021993 42348000.0 352580.0 371731.0 389504.0 405420.0 427410.0 339857.0 368452.0 341471.0 294580.0 458600.0 True False 332985.0150895693 400241.5723964447 364443.73669989075 350201.0966114916 373714.9347061194 386669.2168353226 385585.7480737868 342464.6240764331 353504.23125290626 445359.02641410206 0.7476777057168129 0.8986941964982058 0.8183144723354614 0.7863343411521403 0.8391318296951574 0.8682191084093832 0.8657863099315807 0.7689630248068755 0.7937511317536703 1.0 18.764609308924648 -10.747917132562625 3.6785797344963878 1.0002465426444185 0.823707636517831 0.5819555957031566 0.04551213065422322 67600517.28594346 107535281.2560928 189950.38284916407 0.01136170389058571 1.7868284858655714e-11 10.747917132562625 -0.1765389061265875 LQTTDNLLPMS(ph)PEEFDEVSR ddPTM_A459_Selumetinib_30min_R1 6 LQTTDNLLPMSPEEFDEVSR 20 0 A0A669KB68;A0A669KB56;A0A669KBA4;A0A669KB53;P42224 A0A669KB68 STAT1 Signal transducer and activator of transcription 1-alpha/beta 1 LQTTDNLLPMS(1)PEEFDEVSR;LQTTDNLLPMS(1)PEEFDEVSR;LQTTDNLLPMS(1)PEEFDEVSR;LQTTDNLLPMS(1)PEEFDEVSR;LQTTDNLLPMS(1)PEEFDEVSR;LQTTDNLLPMS(1)PEEFDEVSR 166.43 2.2455e-09 30751700.0 9245.3 11156.89 11502.8 11871.73 11792.4 9350.14 10071.310000000001 10093.900000000001 5148.799999999999 7817.630000000001 True False 9460.69750177779 9850.636132102556 9940.78294035761 9798.555215472095 10725.779502117322 9256.086080847868 9311.622978241798 9826.176982391951 8737.137546526692 8821.098960664693 1.0725078070164742 1.116713028164496 1.1269324813932875 1.110808897980411 1.2159232710058052 1.0493121233672678 1.0556080392890346 1.1139402274262122 0.9904817512520374 1.0 13.106742687194977 -8.012732853536988 0.8882436485520522 0.994630576322343 1.1207840701174263 0.46423100658228034 0.046212491590487965 0.5223381284547569 0.7941876257749665 0.043459834774465585 0.016904119859683674 9.711071382291294e-09 8.012732853536988 0.12615349379508334 LQTTDNLLPMS(ph)PEEFDEVSR ddPTM_A459_Selumetinib_30min_R2 2 LQTTDNLLPMSPEEFDEVSR 20 0 A0A669KB68;A0A669KB56;A0A669KBA4;A0A669KB53;P42224 A0A669KB68 STAT1 Signal transducer and activator of transcription 1-alpha/beta 1 LQTTDNLLPMS(0.745)PEEFDEVS(0.255)R;LQTTDNLLPMS(1)PEEFDEVSR 113.23 0.00020384 2866700.0 12873.8 8666.9 12756.3 14031.400000000001 16259.7 12129.900000000001 11031.5 13099.599999999999 11417.3 15106.099999999999 True False 12158.325733904625 9331.623361524162 11935.573546009304 12120.299114484906 14217.0111224377 13800.68362073103 11544.486608502559 13137.717667244478 13701.079026016041 14669.947642638637 0.8287913515496191 0.6361047488950486 0.8136070991363463 0.8261992073684638 0.9691248713877844 0.9407452539652517 0.7869480443780295 0.8955531394712898 0.9339555504747303 1.0 13.840576101560044 -5.788388572979534 2.206377725148917 0.9087409238305981 0.734637877864923 0.5054388264449223 0.0718554188135142 0.2490618179859582 2.4750701871604925 0.021486652873005285 0.0398713589063287 1.627838917018363e-06 5.788388572979534 -0.17410304596567516 LQWDGSSDLS(ph)PSDSGSSK ddPTM_A459_Selumetinib_30min_R1 1 LQWDGSSDLSPSDSGSSK 18 0 K7EJK2;K7ENU1;K7EKG9;Q14CW9;Q14CW9-2 K7EJK2 ATXN7L3 Ataxin-7-like protein 3 1 LQWDGSS(0.002)DLS(0.988)PS(0.01)DSGSSK 195.55 2.8522e-10 16997000.0 3088.2 3185.1 3469.8 3540.7 3435.8 2782.9 2948.4 2423.0 1454.8 2425.9 True False 3160.1490514088414 2812.187011287181 2998.6202182471065 2922.3832121705964 3125.0324966397598 2754.9065526710306 2725.999814229542 2358.7341689867817 2468.689345611992 2737.2878952670417 1.1544817981597608 1.0273625277595555 1.0954712595017595 1.0676199669108963 1.1416528389444 1.0064365379448954 0.9958761805592253 0.8617048185049131 0.9018742054427396 1.0 11.418531463329609 -7.243462722310851 1.9216555234746233 0.9155341249570516 1.0903134389074323 0.6765669903614644 0.05112212917190858 0.18808461613586858 1.356693638628122 0.024958303549247725 0.015975588926536353 5.7087007473111066e-08 7.243462722310851 0.1747793139503807 LQWDGSSDLS(ph)PSDSGSSK ddPTM_A459_Selumetinib_30min_R2 1 LQWDGSSDLSPSDSGSSK 18 0 K7EJK2;K7ENU1;K7EKG9;Q14CW9;Q14CW9-2 K7EJK2 ATXN7L3 Ataxin-7-like protein 3 1 LQWDGSS(0.003)DLS(0.996)PSDSGSSK 157.73 2.0094e-05 12191000.0 121890.0 114390.0 127750.0 135810.0 126840.0 92215.0 117170.0 102360.0 91215.0 123140.0 True False 115115.8417643303 123163.34517817786 119530.7040836835 117312.44371468236 110905.22523601285 104916.77920557557 122618.63716795036 102657.85065338989 109460.54876004421 119584.62824385689 0.9626307616191786 1.0299262287041044 0.9995490711392819 0.9809993595118172 0.9274204123447621 0.8773433571380876 1.025371228465138 0.8584535668250779 0.9153396248958716 1.0 16.867672427671586 -6.148995672010522 3.4527728810087646 0.9285772439169008 0.9994770232454504 0.2556316751982536 0.049503727749667346 0.31285238065631027 6.916138006995045 0.01477436227855386 0.019663549953622683 7.095848393413221e-07 6.148995672010522 0.07089977932854963 LQWDGSSDLSPSDS(ph)GSSK ddPTM_A459_Selumetinib_30min_R1 1 LQWDGSSDLSPSDSGSSK 18 0 K7EJK2;K7ENU1;K7EKG9;Q14CW9;Q14CW9-2 K7EJK2 ATXN7L3 Ataxin-7-like protein 3 1 LQWDGSSDLS(0.012)PS(0.288)DS(0.696)GS(0.004)SK 244.52 1.4507999999999995e-25 17130000.0 3411.0 3876.5 3975.2 4688.0 4170.0 3629.5 3496.1 3769.3 2005.6 3224.4 True False 3490.469663349383 3422.6375778640418 3435.389674210591 3869.3288046588987 3792.8242362732967 3592.9905253223283 3232.3863622737417 3669.3259195880632 3403.356716771662 3638.2831483156974 0.9593727373762146 0.9407287553879674 0.9442337317261759 1.0635040338875663 1.0424763773619825 0.9875511000252036 0.8884372739846097 1.0085322582127059 0.9354293159803155 1.0 11.829042109337829 LQYKT(ph)PPPSYNSALAQPVTTVPSMGETER ddPTM_A459_Selumetinib_30min_R1 2 LQYKTPPPSYNSALAQPVTTVPSMGETER 29 1 E9PR71;Q9P2Y5-2;Q9P2Y5 E9PR71 UVRAG UV radiation resistance-associated gene protein 1 LQY(0.046)KT(0.37)PPPS(0.282)Y(0.247)NS(0.052)ALAQPVT(0.001)TVPSMGETER;LQY(0.233)KT(0.725)PPPS(0.022)Y(0.019)NS(0.001)ALAQPVTTVPSMGETER 85.76 5.933099999999998e-06 51086000.0 3477.7 3254.2 4195.0 4476.6 3383.7 3419.9 3771.4 3218.2 2151.46 3063.61 True False 3558.723643573774 2873.1967511634625 3625.342041485566 3694.8458461894247 3077.644932440755 3385.4989110207575 3486.920261628441 3132.8428818131515 3650.870483578758 3456.8541855884687 1.0294688327931205 0.8311593711825457 1.0487402264751342 1.0688463116532763 0.8903022132872637 0.9793583209655793 1.0086975250981998 0.9062698955813319 1.0561251032222123 1.0 11.755244034873597 -5.984420588639757 0.0047777960161223985 1.8901291186444968 0.05675562792656203 0.012169342980966724 0.0754867121372519 109947.78475263671 130.25465688912828 24454.361232269348 25530.322097788838 1.0365241170049548e-06 5.984420588639757 -1.8333734907179349 LQYKT(ph)PPPSYNSALAQPVTTVPSMGETER ddPTM_A459_Selumetinib_30min_R2 2 LQYKTPPPSYNSALAQPVTTVPSMGETER 29 1 E9PR71;Q9P2Y5-2;Q9P2Y5 E9PR71 UVRAG UV radiation resistance-associated gene protein 1 LQY(0.088)KT(0.729)PPPS(0.088)Y(0.061)NS(0.033)ALAQPVTTVPSMGETER;LQY(0.179)KT(0.786)PPPS(0.017)Y(0.005)NS(0.013)ALAQPVTTVPSMGETER 67.218 0.00073659 20608000.0 61915.0 53034.0 60378.0 64772.0 78530.0 45174.0 55708.0 53347.0 47191.0 56187.0 True False 58474.01216538281 57101.53726881268 56493.345214595895 55949.941862067666 68664.35933289259 51396.308451257086 58298.532383307866 53502.23093792873 56630.51862670882 54564.73531864197 1.0716447504768751 1.046491601862568 1.035345354186938 1.0253864796619372 1.2584017668538658 0.9419326997761062 1.068428757930587 0.9805276361278301 1.037859311439949 1.0 15.735681231467936 LRDLEDSLAR ddPTM_A459_Selumetinib_30min_R1 4 LRDLEDSLAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;; 182.16 0.00041165 58508000.0 15593.399999999998 15058.000000000002 26229.899999999998 29111.0 22575.699999999997 18398.7 16837.600000000002 14918.400000000001 9582.5 10957.3 False True 15956.695880525429 13295.002359725719 22668.023650527353 24027.310331148707 20533.731921063554 18213.625782682993 15567.526275970471 14522.71557020735 16260.802621890916 12363.776188140302 1.2906005121502895 1.075318912071433 1.833422354593509 1.9433634162834823 1.6607977699208203 1.4731442486118471 1.2591239148200775 1.174618122264132 1.3151971027661238 1.0 13.593831823104212 -7.243705124047706 2.711797328461648 1.1881379592443644 1.5697375734630294 0.3489840391842415 0.2436142099233245 0.3822801147046597 5.593368837400139 0.12485377381029521 0.0852276217077098 5.705515321472916e-08 7.243705124047706 0.38159961421866506 LRDLEDSLAR ddPTM_A459_Selumetinib_30min_R2 3 LRDLEDSLAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;; 150.15 0.0019314 10840900.0 72301.0 97933.0 97218.0 91815.0 93964.0 52256.2 40129.9 39661.9 30400.3 80827.0 False True 68282.79986383491 105444.1461957729 90963.09972295522 79309.63861029045 82159.40227118178 59454.0172154465 41996.01986588831 39777.30956261899 36481.20945535241 78493.31449623372 0.8699186714444485 1.3433519386015014 1.1588642970009861 1.0103999190159807 1.0467057328191176 0.7574405234002347 0.5350267106876136 0.5067604778560802 0.46476836517207915 1.0 16.260282160256004 -6.835032584044198 2.182677435509604 0.5845782362152718 1.1149937854276055 0.5958863581586848 0.1793944749544258 0.19038655727759105 1.858932403758825 0.06977326952062264 0.06124861196956528 1.4620674750236954e-07 6.835032584044198 0.5304155492123337 LREIMRS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 LREIMRSR 8 2 I3L0U5;Q6PK04;I3L385 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 LREIMRS(1)R 120.87 0.0081096 4363500.0 4324.1 5425.5 5568.7 5757.8 5798.0 4466.3 4881.0 4683.3 2634.2 4111.1 True False 4424.843116766067 4790.279937753479 4812.501126679538 4752.308317292021 5273.571923720043 4421.37307707594 4512.822240284354 4559.083670497646 4470.04500564415 4638.799730505108 0.9538767297212585 1.0326550435562514 1.037445332039699 1.0244693872081763 1.1368397495241331 0.9531286828359171 0.9728426538028111 0.9828153693544384 0.9636210367627613 1.0 12.179535847158538 LREQGTES(ph)R ddPTM_A459_Selumetinib_30min_R1 2 LREQGTESR 9 1 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 LREQGT(0.001)ES(0.999)R;LREQGTES(1)R 179.19 0.0046395 12402900.0 4027.5 8700.0 6522.799999999999 5136.9 5415.9 7761.5 5856.7 6357.299999999999 6561.7 4770.3 True False 4121.332913849202 7681.399955479726 5637.039587175697 4239.83684655552 4926.032801254807 7683.42635687815 5414.92440374378 6188.683752579311 11134.725652393608 5382.614471656859 0.7656749216483615 1.4270760047793767 1.047267943275254 0.7876909759896714 0.9151747403039423 1.4274524763637888 1.0060026465311709 1.149754229132879 2.068646326246389 1.0 12.394091381067707 -8.028474223756872 24.4775526904315 1.5592824439053445 1.0674798828115968 0.2576636796194348 0.3206073848581396 690.1253469600523 593253.5853234932 0.20291287880161912 0.07708149548175393 9.365388036894897e-09 8.028474223756872 -0.49180256109374776 LREQLQLLEEQHR ddPTM_A459_Selumetinib_30min_R1 1 LREQLQLLEEQHR 13 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 113.69 0.003569 8013600.0 2850.8 3201.0 4538.4 5113.3 4609.3 3384.7 3008.2 3180.7 2048.2 2666.8 False True 2917.2180933088307 2826.225431895473 3922.110207646746 4220.358143528659 4192.38962883801 3350.6529910617123 2781.2890520842866 3096.337503630318 3475.645805390765 3009.1097568317523 0.9694621762086628 0.9392231125763801 1.303412146646415 1.4025271540683888 1.3932325397303273 1.1135030829149835 0.9242896659949902 1.0289878913856592 1.1550412202478855 1.0 11.555121014380536 -6.998123760517413 24.984341558815498 1.0279811972643365 1.208773476088173 0.22084986361543812 0.1543144687014884 104.62257115453205 1393147.1760932284 0.062188835474008886 0.05448117490922688 1.0043295465854373e-07 6.998123760517413 0.18079227882383653 LRESTPGDS(ph)PSTVNK ddPTM_A459_Selumetinib_30min_R1 2 LRESTPGDSPSTVNK 15 1 Q5T6F2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 LRESTPGDS(0.992)PS(0.007)T(0.001)VNK;LRESTPGDS(0.991)PS(0.008)T(0.001)VNK 249.36 2.6444e-27 26401000.0 6489.6 7334.6 9473.1 9792.2 7596.7 6244.700000000001 6415.7 6699.9 3901.4 5201.4 True False 6640.795053436571 6475.861622236972 8186.705052013569 8082.176092359394 6909.579826306314 6181.8839877339415 5931.758583690298 6522.196887657671 6620.390853018027 5869.050355926456 1.1314939642204334 1.10339172941288 1.394894327963431 1.377084128132955 1.1772909427040699 1.0533022572368274 1.0106845612085302 1.111286578257363 1.1280173880827042 1.0 12.518911371024668 -6.597988807848789 4.325792582840351 1.065549901805987 1.2542332678809351 0.4844165773087483 0.09307585766897897 0.21173945571975014 7.621580348642055 0.03477508442719996 0.035011129135195246 2.5235458056400784e-07 6.597988807848789 0.18868336607494807 LRESTPGDS(ph)PSTVNK ddPTM_A459_Selumetinib_30min_R2 4 LRESTPGDSPSTVNK 15 1 Q5T6F2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 LREST(0.002)PGDS(0.998)PSTVNK;LRES(0.004)T(0.004)PGDS(0.797)PS(0.098)T(0.098)VNK;LRES(0.009)T(0.491)PGDS(0.5)PSTVNK;LRESTPGDS(0.981)PS(0.01)T(0.01)VNK 167.69 0.00033768 25244800.0 118446.0 138317.0 140599.0 161976.0 153296.0 114598.0 102802.3 98722.0 88891.7 135119.0 True False 111863.24549690606 148925.4691407471 131553.01341261689 139914.58937581506 134037.5859963719 130382.83428293186 107582.81064889282 99009.264675693 106672.52384161853 131217.76338867674 0.8525007789193818 1.134948998479869 1.0025549134147875 1.0662778099743835 1.0214896408449108 0.9936370725717084 0.8198799299011412 0.754541626977898 0.8129427075025399 1.0 17.001603510079228 -7.211221704496324 4.324475504079451 0.8255195483722554 1.022395526292 0.44328074080383717 0.08930589418814794 0.17007907508515133 6.883136239665027 0.03409871423722008 0.025338697179648668 6.148629090795197e-08 7.211221704496324 0.19687597791974454 LREVIEIEDAS(ph)PTKCPITTK ddPTM_A459_Selumetinib_30min_R1 1 LREVIEIEDASPTKCPITTK 20 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LREVIEIEDAS(0.985)PT(0.015)KCPITTK 91.416 0.0017497 20746000.0 1694.8 1942.4 3001.2 3036.3 2149.9 2077.2 1699.9 1370.1 1153.5 1551.5 True False 1734.285542493267 1714.9829050027386 2593.6535244115553 2506.0672034099425 1955.4419245956742 2056.3052539466985 1571.675174402659 1333.760497287987 1957.4052516933145 1750.6501378897794 0.9906522753791125 0.9796262930467455 1.481537326206095 1.4315065867076886 1.1169804190303547 1.1745952029143605 0.8977665727643014 0.761865816830593 1.1181019035892323 1.0 10.773675079019588 -7.2047858362018085 4.614943206818557 0.924130444968686 1.2093318855661668 0.33000803129260103 0.17423419758542655 0.25746066576441784 11.608063926146716 0.07515578055300168 0.056445208883398844 6.240424939237336e-08 7.2047858362018085 0.28520144059748076 LRGAVAAEGASDT(ph)EREEPTESQGLAAR ddPTM_A459_Selumetinib_30min_R1 1 LRGAVAAEGASDTEREEPTESQGLAAR 27 2 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 LRGAVAAEGAS(0.261)DT(0.724)EREEPT(0.011)ES(0.004)QGLAAR 58.345 0.0087281 9278100.0 608.47 469.59 1386.0 1696.4 958.9 486.72 472.24 467.1 271.51 407.2 True False 622.6461671234828 414.6101844935318 1197.7888127530382 1400.1555853718764 872.1676643075456 481.82403870640144 436.61855659739484 454.71099064536764 460.7326396941933 459.4680864638856 1.3551456248363902 0.9023699288549398 2.606903173561729 3.0473402323709142 1.8982116277538208 1.0486561589392849 0.9502696040494496 0.9896465152669709 1.0027522112363447 1.0 8.843820848679202 -6.752623313327279 5.192253587836788 0.9879756136424607 2.0067717568283348 0.42915269759834396 0.5560260379329696 0.19653596075642402 15.121949194375594 0.21814692363068153 0.20643288012568148 1.7675702635837637e-07 6.752623313327279 1.018796143185874 LRLCDDGPQLPT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 LRLCDDGPQLPTSPR 15 1 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 LRLCDDGPQLPT(0.5)S(0.5)PR 88.19 0.024754 12097000.0 57495.0 80635.0 74367.0 76528.0 69226.0 86196.0 45983.0 50340.0 30449.0 83492.0 True False 54299.65807072093 86819.44521760951 69582.30818466762 66104.75438183657 60529.21099170787 98068.71659061752 48121.3006135859 50486.48106576437 36539.6508161441 81081.36902173219 0.6696934046114469 1.070769355094872 0.8581787533214631 0.8152890753992887 0.7465242844565718 1.2095098759905278 0.5934939332448615 0.6226643885629571 0.45065409300563736 1.0 16.30708282780406 LRLCDDGPQLPTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 LRLCDDGPQLPTSPR 15 1 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 LRLCDDGPQLPT(0.013)S(0.987)PR;LRLCDDGPQLPT(0.045)S(0.955)PR 133.9 0.00027382 70657000.0 5524.8 5278.5 10217.0 9963.4 7378.0 6076.0 5888.6 5170.9 3734.0 3484.2999999999997 True False 5653.517090610574 4660.490766091927 8829.587517963775 8223.479226181415 6710.661202691701 6014.8809565666015 5444.418161060942 5033.75093454963 6336.325279430287 3931.5438449560784 1.43798907339255 1.1854098414980265 2.2458321377470014 2.0916666710283844 1.706876857370179 1.5299030594007779 1.3848041318541533 1.2803496878224094 1.611663389576436 1.0 11.940880228213503 -6.99331334095149 2.38199952550341 1.3408521840996803 1.7518012762823783 0.28049836763587865 0.3121583458018983 0.46235744432613807 5.274218916115453 0.1422044042983968 0.1132291991314556 1.0155157397715446e-07 6.99331334095149 0.41094909218269793 LRLCDDGPQLPTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LRLCDDGPQLPTSPR 15 1 O60504-2;O60504;H0YAZ3;H0YB51 O60504-2 SORBS3 Vinexin 1 LRLCDDGPQLPT(0.224)S(0.776)PR 83.89399999999998 0.012439 9838200.0 51170.0 58608.0 78951.0 55017.0 63129.0 80644.0 34269.0 29890.0 28823.0 69931.0 True False 48326.176249739794 63103.04514557781 73871.37861534923 47523.5896903813 55198.17063957943 91751.97898665557 35862.57640273527 29976.97495144414 34588.40538190816 67911.91032744129 0.7116008961717065 0.9291896641004905 1.0877529178486367 0.6997828431160823 0.8127907221787487 1.3510440001506065 0.5280749169007577 0.4414096850892337 0.5093128026459294 1.0 16.051376994718723 LRLDTGPQSLS(ph)GK ddPTM_A459_Selumetinib_30min_R1 1 LRLDTGPQSLSGK 13 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 LRLDTGPQS(0.007)LS(0.993)GK 115.04 0.019377 11518000.0 1907.9 2328.7 2127.0 2141.5 2261.8 1968.0 2164.0 2314.7 1085.9 1770.9 True False 1952.3503578728494 2056.054721416742 1838.165082774684 1767.5272259336664 2057.2205893532237 1948.2037068010313 2000.7677377536054 2253.3066367947617 1842.6929890019687 1998.212265026754 0.9770485308510052 1.0289471030692594 0.9199048143917147 0.8845542872843897 1.029530558569402 0.9749733503787431 1.001278879512241 1.127661298167736 0.9221707929899514 1.0 10.964494129772229 -6.326657360173711 24.999562494615464 1.013537939524127 0.9557285004849755 0.17502139681671558 0.05967686639410686 358.4602152899543 137404.81563626527 0.01880477879494556 0.02132261757945573 4.713490540426025e-07 6.326657360173711 -0.05780943903915159 LRLDTGS(ph)PEPETR ddPTM_A459_Selumetinib_30min_R1 3 LRLDTGSPEPETR 13 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 LRLDT(0.036)GS(0.962)PEPET(0.002)R;LRLDT(0.02)GS(0.98)PEPETR;LRLDT(0.203)GS(0.797)PEPETR 110.04 0.0031498 61716000.0 11155.6 9663.7 13082.400000000001 14060.7 15794.0 9967.8 11593.8 9694.6 4709.9 6516.2 True False 11415.50377498105 8532.269511467759 11305.88193647933 11605.262697028025 14365.43548865718 9867.532982038267 10719.27033177807 9437.467715501136 7992.356302514382 7352.617743162988 1.5525768064844712 1.160439697739176 1.537667580637166 1.57838515511288 1.953785167468448 1.3420435179312613 1.4578848930023116 1.2835520688229436 1.0870082712985143 1.0 12.84404226695256 -8.03582713706829 1.3874416501792302 1.0020516386246907 1.525276069575859 0.5090286693275318 0.1875106414942827 0.38042543646431654 1.3169178318529724 0.18098905265230664 0.060225463530555315 9.208160127005531e-09 8.03582713706829 0.5232244309511682 LRLDTGS(ph)PEPETR ddPTM_A459_Selumetinib_30min_R2 3 LRLDTGSPEPETR 13 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 LRLDT(0.162)GS(0.838)PEPETR;LRLDT(0.032)GS(0.968)PEPETR;LRLDT(0.062)GS(0.938)PEPETR 82.59 0.018004 44116000.0 135685.0 134264.0 167161.0 179493.0 202371.0 102843.0 99688.0 101374.0 106565.0 150371.0 True False 128144.17089009086 144561.61707319584 156406.04325113562 155045.74375730468 176947.34576030535 117008.68973419745 104323.68952802446 101668.98155663098 127880.97767487925 146029.3985192219 0.8775231028101729 0.9899487263461346 1.0710586007826899 1.0617433566768815 1.2117241292137058 0.8012680386326152 0.7144019669045771 0.6962226961665412 0.8757207724720323 1.0 17.15589931496895 -6.839369638835451 10.330576537637798 0.7913914283186717 1.0420164038416393 0.4950885076479834 0.11201868365757373 0.3137530608720511 39.393797366270576 0.03985321212787104 0.035159652924893814 1.4475392923920545e-07 6.839369638835451 0.2506249755229676 LRLS(ph)PSPTSQR ddPTM_A459_Selumetinib_30min_R1 1 LRLSPSPTSQR 11 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 LRLS(0.91)PS(0.078)PT(0.011)S(0.001)QR 143.55 0.0039413 253600000.0 6134.8 6765.7 7236.4 8173.3 7064.1 5559.9 6464.6 6050.5 3567.9 5298.8 True False 6277.728903757193 5973.568698711405 6253.736626699914 6745.9865868427 6425.153402268153 5503.97245398529 5976.970017320685 5890.02108520616 6054.465710894298 5978.952594682796 1.0499713460414628 0.9990995252285193 1.0459585567314063 1.128289023873854 1.0746285909646067 0.920557968444186 0.9996684072451294 0.98512590490252 1.0126298235377644 1.0 12.545677056910412 -6.735578043149795 24.99997628648135 0.9836712582154911 1.0592882577997937 0.5036049753164036 0.03772287474039164 208.25256483929164 201315.81953748243 0.013433736436784076 0.013429354205005283 1.8383235756076686e-07 6.735578043149795 0.07561699958430268 LRLS(ph)PSPTSQR ddPTM_A459_Selumetinib_30min_R2 4 LRLSPSPTSQR 11 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 LRLS(0.773)PS(0.227)PTSQR;LRLS(0.93)PS(0.068)PT(0.001)SQR;LRLS(0.922)PS(0.078)PTSQR;LRLS(0.836)PS(0.071)PT(0.085)S(0.009)QR 184.96 0.00010536 1909672000.0 686821.0 609588.0 621792.0 695309.0 771508.0 484067.0 488503.0 548863.0 472368.0 592249.0 True False 648650.2383823048 656341.4394656437 581786.5796759427 600606.7147250716 674584.2676709703 550742.8353272822 511219.3574503304 550460.1004608393 566854.7990646766 575149.2325222972 1.127794669111652 1.1411672003582112 1.0115402173528731 1.0442623944591414 1.1728856260706533 0.9575651051676074 0.8888464567854772 0.9570735199398868 0.9855786411793586 1.0 19.133576811513223 -6.822723648782892 10.138069106199037 0.950514816511267 1.0938156172939832 0.6531228594740365 0.05142135337205895 0.2760885995683291 43.859879874493565 0.018880715093338035 0.016664467454794333 1.5040987530622978e-07 6.822723648782892 0.14330080078271623 LRLSPSPTSQR ddPTM_A459_Selumetinib_30min_R2 1 LRLSPSPTSQR 11 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 99.752 0.047751 1424300.0 5785.4 3686.6 6055.8 6458.0 6460.8 3862.6 4342.6 2840.3 4444.8 5880.9 False True 5463.870628791174 3969.3503657126535 5666.176421056503 5578.409259328615 5649.136543715166 4394.638088808291 4544.539504698651 2848.564802763023 5333.884198088521 5711.103136586787 0.9567102008346201 0.6950234080494853 0.9921334434949228 0.9767656310725504 0.9891498032184629 0.7694902339716326 0.795737600251897 0.4987766346775265 0.9339498990866222 1.0 12.479553723064567 -6.7818002765054315 23.505657711619083 0.7680234402014612 0.9162927485375634 0.12803006598954791 0.1482968035456268 207.25287765013672 239260.4184282916 0.05146239122989708 0.045455203060831374 1.652721677698045e-07 6.7818002765054315 0.1482693083361022 LRPISDDSES(ph)IEESDTR ddPTM_A459_Selumetinib_30min_R2 1 LRPISDDSESIEESDTR 17 1 D6R9S4;Q09GN1;Q71F23-3;Q71F23 D6R9S4 CENPU;MLF1IP Centromere protein U 1 LRPISDDS(0.011)ES(0.974)IEES(0.015)DTR 106.73 0.0013853 4165600.0 11677.0 9365.3 13106.0 12010.0 12984.0 9659.0 10374.0 9180.2 10418.0 11646.0 True False 11028.039086734643 10083.588395814222 12262.774228733877 10374.217281594409 11352.833841567257 10989.439574327978 10856.41155569102 9206.912862136074 12501.891103241138 11309.7497200581 0.9750913468205369 0.8915836906568098 1.084265747011675 0.9172808893547394 1.0038094672804958 0.971678405476821 0.9599161629931496 0.8140686655344286 1.105408290430048 1.0 13.465279383003953 -6.733088987464637 0.002184727296994008 1.9336401025405496 7.601049853977375e-05 0.0072786877393646865 0.08140596321216959 731566.9123997575 618.6016407396972 272089.3561607322 275384.70376974845 1.8488897404189562e-07 6.733088987464637 -1.9335640920420099 LRPS(ph)LDFDK ddPTM_A459_Selumetinib_30min_R2 4 LRPSLDFDK 9 1 Q9NYF3 Q9NYF3 FAM53C Protein FAM53C 1 LRPS(1)LDFDK;LRPS(1)LDFDK;LRPS(1)LDFDK;LRPS(1)LDFDK 70.54 0.040178 12192400.0 117034.0 88046.0 101822.0 119216.0 118890.0 94762.0 108587.0 111456.0 94351.0 104148.0 True False 110529.71880422221 94798.84508748873 95270.88337541111 102978.57514092939 103953.9753099147 107814.6053362116 113636.51066105865 111780.31850746601 113223.83638720527 101140.97663099848 1.0928282728322616 0.937294143731197 0.9419612757250333 1.0181686846532556 1.027812650941459 1.065983431518178 1.123545712591334 1.1051931890600974 1.1194655238528075 1.0 16.62600808894104 -6.63145673217093 1.7574876486775928 1.0955628126858539 0.9884303845709911 0.37304953731041124 0.05209790833775049 0.326436336729527 2.0708099729310634 0.020483788028989095 0.02061701639634792 2.3363788590459307e-07 6.63145673217093 -0.10713242811486279 LRPSTSVDEEDEES(ph)ERER ddPTM_A459_Selumetinib_30min_R1 1 LRPSTSVDEEDEESERER 18 2 A0A0A0MQV9;Q9UPS6-2;Q9UPS6 A0A0A0MQV9 SETD1B Histone-lysine N-methyltransferase;Histone-lysine N-methyltransferase SETD1B 1 LRPSTSVDEEDEES(1)ERER 72.916 0.021334 9923200.0 1934.5 2863.6 2404.5 2254.8 2145.8 2117.7 2120.3 2568.0 1644.2 2542.1 True False 1979.5700861182584 2528.3283807484786 2077.9821069730724 1861.0415078380715 1951.7127688717603 2096.397860717755 1960.364063936677 2499.8882979604027 2790.08731238331 2868.4032971508923 0.6901296230151848 0.8814410383852923 0.7244386132999764 0.6488074775561002 0.680417837620792 0.7308588240712353 0.6834339041109923 0.8715260857646742 0.9726970106172408 1.0 11.486032165708435 -7.99576907389585 2.832831851629135 0.984421825625892 0.7224483232311061 0.7612786620228247 0.06053992410191427 0.14239261782960522 2.2165796159650792 0.0489738790138341 0.017687082937237104 1.0097896757912318e-08 7.99576907389585 -0.2619735023947859 LRPVS(ph)PEEIR ddPTM_A459_Selumetinib_30min_R2 4 LRPVSPEEIR 10 1 J3KNG6;Q08AE8-4;Q08AE8-3;Q08AE8-5;Q08AE8-2;Q08AE8;K7EMJ7 J3KNG6 SPIRE1 Protein spire homolog 1 1 LRPVS(1)PEEIR;LRPVS(1)PEEIR;LRPVS(1)PEEIR;LRPVS(1)PEEIR 88.163 0.017947 15527900.0 33924.3 27192.3 29279.199999999997 34022.0 41793.3 32542.1 32661.9 39172.3 35209.6 32165.4 True False 32038.923215732786 29277.86197297459 27395.408148782604 29388.14490877643 36542.85201715751 37024.47888722837 34180.74306832704 39286.28490767665 42252.503838421886 31236.70132625424 1.0256820296451816 0.9372904541737492 0.8770262859272194 0.940821010574375 1.1698691111933603 1.1852877325465074 1.094249444309869 1.2576963392308262 1.3526557557122378 1.0 14.930954488870386 -6.274091283896819 5.371164477509381 1.1870863946644257 0.9387055047378933 0.5939179092889654 0.0935261098035224 0.11973867871518487 11.870304805954808 0.029118798071346316 0.034807500145974925 5.319964277490748e-07 6.274091283896819 -0.2483808899265324 LRRPS(ph)PPEPWDEEDGASCSTFFGSEER ddPTM_A459_Selumetinib_30min_R1 3 LRRPSPPEPWDEEDGASCSTFFGSEER 27 2 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 LRRPS(1)PPEPWDEEDGASCSTFFGSEER;LRRPS(1)PPEPWDEEDGASCSTFFGSEER;LRRPS(1)PPEPWDEEDGASCSTFFGSEER 89.079 4.2754e-05 92685000.0 6040.1 6029.0 8137.599999999999 8854.0 7112.5 6160.5 5912.5 5131.6 3331.67 3942.8 True False 6180.82257801132 5323.121877193939 7032.55861663717 7307.815110164219 6469.1756308138665 6098.530963286462 5466.51536481894 4995.4932982140235 5653.60065445086 4448.896786124281 1.3892933181297358 1.1965037925348796 1.5807421378196735 1.6426128681961456 1.4541078253356334 1.3707962347670652 1.2287350387333151 1.1228611357751723 1.2707871021157302 1.0 12.119231913210864 -7.262000420295488 2.0210327498858853 1.1462684876641518 1.4549416708895986 0.5590551980226923 0.12675624245171246 0.28999586270246985 2.3135820009570915 0.06964320669328351 0.04441099905543905 5.4701543351070916e-08 7.262000420295488 0.3086731832254468 LRRPS(ph)PPEPWDEEDGASCSTFFGSEER ddPTM_A459_Selumetinib_30min_R2 1 LRRPSPPEPWDEEDGASCSTFFGSEER 27 2 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 LRRPS(0.998)PPEPWDEEDGAS(0.001)CST(0.001)FFGS(0.001)EER 59.07 0.0068631000000000005 4030800.0 8278.8 10190.0 8429.5 9494.7 9231.1 6848.9 6427.7 3560.2 3859.7 10072.0 True False 7818.697438662214 10971.540233985763 7887.1551473456575 8201.505480728927 8071.406690918933 7792.273806875964 6726.6007862459255 3570.55959257716 4631.747849028588 9781.195189801234 0.7993601279744117 1.1216972998786172 0.8063590383688002 0.8384972717118011 0.8251963624378867 0.7966586552736314 0.687707448396459 0.3650432818578399 0.47353597992381036 1.0 13.25579504728815 -7.233808548698073 2.1305731201439455 0.5637555054225114 0.8836962272597834 0.2845558125620439 0.17860180620902882 0.34009558394405853 3.020051669832718 0.0850191988296233 0.056048630107262944 5.8370236277897555e-08 7.233808548698073 0.31994072183727196 LRS(ph)PPEALVQGR ddPTM_A459_Selumetinib_30min_R1 2 LRSPPEALVQGR 12 1 Q9UHB6;Q9UHB6-4;F8VRN8 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 LRS(1)PPEALVQGR;LRS(1)PPEALVQGR 107.11 0.004741 18251600.0 3984.1000000000004 4831.200000000001 5338.9 5409.4 4612.700000000001 4515.0 4730.5 4985.700000000001 3089.6 5350.9 True False 4076.921778290905 4265.560858036054 4613.906704478497 4464.749837014043 4195.482099438332 4469.583199292002 4373.674576452601 4853.463040164011 5242.8255445441355 6037.740137179775 0.6752396899604283 0.7064830153535715 0.76417775519462 0.7394736665661674 0.6948762292042001 0.7402741916249052 0.7243893372488771 0.8038542451134806 0.868342364100661 1.0 12.559792949617336 -8.422126332208464 1.08390788701104 0.9990522946478865 0.718627644559536 0.9299200645390719 0.024588951304704093 0.12188323407106898 0.3111918665423581 0.0242779316529858 0.00794579997713156 3.783325153137196e-09 8.422126332208464 -0.2804246500883505 LRS(ph)PPEALVQGR ddPTM_A459_Selumetinib_30min_R2 2 LRSPPEALVQGR 12 1 Q9UHB6;Q9UHB6-4;F8VRN8 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 LRS(1)PPEALVQGR;LRS(1)PPEALVQGR 106.42 0.0048987 21940000.0 22517.4 32735.0 25597.0 28895.0 29955.0 24270.0 21515.0 24201.0 24990.0 28623.0 True False 21265.973052294117 35245.66924038509 23950.116887906363 24959.45115334475 26191.785098902277 27612.97219887569 22515.490131163708 24271.420903308765 29988.69827893992 27796.579618514774 0.7650571884797386 1.2679858358151597 0.8616210057712872 0.8979324613277144 0.942266475169356 0.9933946038628153 0.8100093766992312 0.8731801263469853 1.0788628921439318 1.0 14.762619749153103 -4.494778304624685 18.742044979175294 0.9584475321444774 0.11480042510486729 0.18979827387316484 0.1248460728464264 26350694.298999783 462134024.1827408 0.03051006931749487 720011758.6352137 3.200528474426148e-05 4.494778304624685 -0.8436471070396101 LRS(ph)PSNDSAHR ddPTM_A459_Selumetinib_30min_R1 3 LRSPSNDSAHR 11 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 LRS(0.968)PS(0.029)NDS(0.002)AHR;LRS(0.997)PS(0.003)NDSAHR;LRS(0.995)PS(0.003)NDS(0.002)AHR 123.28 0.010671 27194700.0 1084.27 1204.3899999999999 1227.71 1556.32 1878.58 1050.0900000000001 1115.51 990.3100000000001 525.56 845.75 True False 1109.5313813778464 1063.3794588942799 1060.9937253283065 1284.53792774461 1708.6627706902368 1039.527048005435 1031.3661825977463 964.0437618197699 891.8369346163317 954.3102508026305 1.1626526912444521 1.1142911416909917 1.1117911857657914 1.3460380695525787 1.7904688430760876 1.0892967429943587 1.0807451578040865 1.010199524744655 0.9345356333186664 1.0 9.898314559284858 -6.98098158023001 24.999853119748263 1.0183342509591997 1.3013805736132 0.3729126591718095 0.18512517178538865 302.49402965470347 397629.35258026497 0.07198059528005019 0.0634727355299419 1.0447645299708514e-07 6.98098158023001 0.2830463226540003 LRS(ph)PSNDSAHR ddPTM_A459_Selumetinib_30min_R2 3 LRSPSNDSAHR 11 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 LRS(0.98)PS(0.02)NDS(0.001)AHR;LRS(0.997)PS(0.001)NDS(0.002)AHR;LRS(0.993)PS(0.007)NDSAHR 86.014 0.014583 111462400.0 25061.0 27136.5 29987.5 31533.3 41950.4 21640.4 26811.5 28629.8 28366.0 38973.9 True False 23668.2099471317 29217.78229239989 28058.136897921344 27238.410142023386 36680.215710665645 24621.16866800778 28058.287875979353 28713.107978081454 34039.99261226129 37848.622240646786 0.6253387454012446 0.7719642238660415 0.7413251853534806 0.719667151127399 0.9691294831671217 0.6505169068364756 0.7413291743509413 0.7586302031159691 0.8993720404359846 1.0 15.207953163967492 -14.522878738649444 0.13282978616102514 1.8245469962001015 0.6674643644164765 0.4489044780215188 0.08959526293825675 142.07579700710883 1.1766614046133925 30.849397774684117 0.6457199957277145 3.0000000458045887e-15 14.522878738649444 -1.157082631783625 LRS(ph)YEDMIGEEVPSDQYYWAPLAQHER ddPTM_A459_Selumetinib_30min_R1 1 LRSYEDMIGEEVPSDQYYWAPLAQHER 27 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 LRS(0.553)Y(0.447)EDMIGEEVPSDQYYWAPLAQHER 85.571 2.608e-05 3750800.0 649.48 725.48 848.42 798.65 779.33 870.09 1012.6 1380.7 736.53 627.01 True False 664.6116203319133 640.5404643334982 733.2092240374693 659.1807700172416 708.8397391018866 861.3376845785109 936.2187667510628 1344.0793508543338 1249.83761597718 707.4928410945989 0.9393898873996493 0.9053667077994525 1.0363486122390768 0.931713696208415 1.0019037620298799 1.2174507423225522 1.3232907986780336 1.8997780228770074 1.766572809476759 1.0 9.466571739599706 -7.2079911197120845 1.8254278374124853 1.6118351779951894 0.9629888343255892 0.5400272472431051 0.23087939783391653 0.23978544038417118 1.5640717480750688 0.11444999106353333 0.07451646661562839 6.194537413011114e-08 7.2079911197120845 -0.6488463436696001 LRTS(ph)TSDLSR ddPTM_A459_Selumetinib_30min_R1 2 LRTSTSDLSR 10 1 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 LRT(0.045)S(0.774)T(0.136)S(0.045)DLSR;LRT(0.006)S(0.762)T(0.116)S(0.116)DLSR 86.699 0.019079 34681000.0 1796.5900000000001 2144.61 2929.9 2595.2 2438.5 2601.9300000000003 2142.27 2029.06 1347.0700000000002 1679.69 True False 1838.447051444405 1893.5180641978604 2532.035672788691 2141.997037937452 2217.9381055521426 2575.7569465634188 1980.6768491485275 1975.242737484242 2285.879403899881 1895.2945730661197 0.9700059703491107 0.999062674006719 1.3359589104360075 1.130165763347398 1.1702339768556742 1.3590272368038698 1.0450496072197792 1.0421824478127355 1.2060813323608535 1.0 10.888206379007856 -10.900693638164418 3.634486440453589 0.9992183797052002 1.1427936580818165 0.09902100612540343 0.1261658574205009 47431508.68410149 348.05321881376955 310533.80838806654 0.03145128917833542 1.25691631021014e-11 10.900693638164418 0.14357527837661632 LRTS(ph)TSDLSR ddPTM_A459_Selumetinib_30min_R2 1 LRTSTSDLSR 10 1 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 LRT(0.059)S(0.794)T(0.116)S(0.031)DLSR 74.392 0.034397000000000004 30135000.0 41986.0 43494.0 40229.0 36795.0 48012.0 34113.0 35217.0 26894.0 47548.0 39866.0 True False 39652.58620327485 46829.849944747504 37640.70993802341 31783.45752508462 41980.3033272741 38811.75610301794 36854.660281161625 26972.257087458613 57058.92860212228 38714.9649956926 1.0242185730424027 1.2096058965817937 0.9722522012408196 0.8209605130372926 1.0843430526656759 1.0025000954368966 0.9519486918110878 0.6966881434726734 1.4738210045771865 1.0 15.240603717283955 -5.287418067278933 23.578335963743832 0.9844278948577388 1.1169122605708575 0.04961890912983247 0.1944121621995633 889.8081470016061 807591.7800991758 0.048376564104605745 0.10078265971289274 5.1591948774657974e-06 5.287418067278933 0.1324843657131186 LRVQS(ph)PEPPAPER ddPTM_A459_Selumetinib_30min_R1 1 LRVQSPEPPAPER 13 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LRVQS(1)PEPPAPER 105.53 0.034512 15992000.0 1947.3 1990.4 2564.7 2322.0 2959.9 1879.1 2424.9 2542.8 1152.5 1460.9 True False 1992.6683012137946 1757.3630426881434 2216.4278268886837 1916.5062893383015 2692.177567612788 1860.1979600862892 2241.9878407018105 2475.356683821541 1955.7083247304245 1648.4207453710458 1.2088347630963971 1.0660888900015486 1.344576518533067 1.1626317460029976 1.6331859297286395 1.1284727914944883 1.3600822769293393 1.5016534405870747 1.1864133172445672 1.0 10.686868809820945 -5.269393830692384 24.699176244790163 1.312038369412788 1.1374618253327153 0.09307987855290523 0.17939148281006417 874.9034225388854 2716648.6550272456 0.04413435771746461 0.09449159399460672 5.37781885292179e-06 5.269393830692384 -0.17457654408007262 LRVQS(ph)PEPPAPER ddPTM_A459_Selumetinib_30min_R2 4 LRVQSPEPPAPER 13 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LRVQS(1)PEPPAPER;LRVQS(1)PEPPAPER;LRVQS(1)PEPPAPER;LRVQS(1)PEPPAPER 115.73 0.0021712 75710000.0 54319.7 47609.4 65450.0 55898.7 55509.0 33608.4 49199.7 43643.7 39528.1 50759.8 True False 51300.828532987885 51260.887891650804 61239.01825657197 48285.20062936398 48535.46316324376 38237.652033320686 51487.583537356055 43770.69594139649 47434.82450739353 49294.232684201044 1.04070650336809 1.0398962535850584 1.2423160869324024 0.9795304237454848 0.9846073368091908 0.7757023479457866 1.0444950805341977 0.8879476068084763 0.9622793970905351 1.0 15.58913124390878 -5.980779914164395 24.5695553263701 0.9380626270693263 1.1025417058227227 0.42448173184381544 0.08606640769057337 182.5941514110586 233412.86353189885 0.023706713731745804 0.03515665656898743 1.0452497824590314e-06 5.980779914164395 0.1644790787533964 LS(ph)AAPVK ddPTM_A459_Selumetinib_30min_R2 1 LSAAPVK 7 0 A7E2S9-2;A7E2S9 A7E2S9-2 ANKRD30BL Putative ankyrin repeat domain-containing protein 30B-like 1 LS(1)AAPVK 93.429 0.025721 17378000.0 94132.0 72923.0 91530.0 94396.0 89611.0 91231.0 123590.0 133630.0 103060.0 76986.0 True False 88900.52028025221 78515.95961559794 85641.05945032879 81539.10195781729 78353.26504749557 103797.24213743824 129337.17988893909 134018.8411763625 123674.87973699658 74763.21414635007 1.1890944135471244 1.0501950793862582 1.1454972933973273 1.0906313069714113 1.0480189481168898 1.3883464391225027 1.729957457898475 1.7925773083273102 1.6542210116181095 1.0 16.19004097288778 -6.957774408568551 3.7812922261388695 1.6077136451790424 1.1047495706135917 0.48793990912857155 0.20934864982079254 0.16270996609640687 4.9297016448548705 0.07497101026992532 0.06346683881371123 1.1021116455748154e-07 6.957774408568551 -0.5029640745654507 LS(ph)AEYEK ddPTM_A459_Selumetinib_30min_R2 2 LSAEYEK 7 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 LS(1)AEYEK;LS(0.991)AEY(0.009)EK 114.4 0.013726 232950000.0 727220.0 382310.0 537810.0 730290.0 640640.0 750960.0 1473350.0 1414350.0 1264060.0 480820.0 True False 686804.0236923143 411631.9476795984 503207.89012325264 630823.2421794819 560157.0758057331 854397.9234638521 1541863.6943876382 1418465.524341754 1516907.3207873867 466937.4772796086 1.4708693499901841 0.8815568843986955 1.077677236479189 1.3509801052052548 1.1996404295265066 1.8297908500332838 3.302077407387775 3.037806116154513 3.248630479662787 1.0 18.832869861079814 -7.028317657968203 3.644694995275571 2.8110185733697017 1.1904239328105755 0.5311319359105935 0.6330622802520941 0.15848815778887462 4.450586327455618 0.23426199515025703 0.18763050640117698 9.368764924610394e-08 7.028317657968203 -1.6205946405591263 LS(ph)ASPAQEK ddPTM_A459_Selumetinib_30min_R1 1 LSASPAQEK 9 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 LS(0.601)AS(0.399)PAQEK 95.618 0.022215 5271700.0 3296.9 3411.9 3303.4 3536.5 3031.1 3038.9 3263.7 2876.3 1578.1 2460.1 True False 3373.711355349336 3012.433161850723 2854.816424277335 2918.916663326834 2756.937540184169 3008.331425100433 3017.516481380057 2800.0111804608678 2677.9204401362963 2775.8777984032513 1.215367390196345 1.0852182194704478 1.0284373562551965 1.0515292369879763 0.993176840050388 1.0837405835483445 1.0870494670607624 1.0086939641476647 0.9647112137561307 1.0 11.438728342665382 -4.70983368720275 1.920924889730149 1.0307155582161802 1.2967378247734629 0.7041570230588946 0.03698705819694024 0.5846457171063936 1.9799270377762817 0.010500131510673392 0.2975823787002548 1.9505914345054972e-05 4.70983368720275 0.26602226655728267 LS(ph)CEPVMEEK ddPTM_A459_Selumetinib_30min_R2 2 LSCEPVMEEK 10 0 C9JEZ4;Q9UKI2 C9JEZ4 CDC42EP3 Cdc42 effector protein 3 1 LS(1)CEPVMEEK;LS(1)CEPVMEEK 128.67 0.0030777 7273900.0 36154.0 30343.0 34919.0 33691.0 34140.0 34611.0 33303.0 36004.0 35960.0 37804.0 True False 34144.705415929086 32670.210531877336 32672.349556932542 29102.227679783286 29851.027984527595 39378.35108262405 34851.65548864259 36108.76567921695 43153.00480634971 36712.50029341203 0.930056660348363 0.8898933679474816 0.8899516321637053 0.7927062294094313 0.8131025603255982 1.0726142531264864 0.9493130462404554 0.9835550668200221 1.1754308331348768 1.0 15.16398375162982 -6.762728582867103 24.999998329883805 1.02972549382709 0.8622045799968178 0.6190614017670213 0.06777352121963683 25.231902531059717 489286.1844531169 0.024024664924383193 0.02235631488929568 1.7269168105472045e-07 6.762728582867103 -0.16752091383027234 LS(ph)DGEINAQESTYK ddPTM_A459_Selumetinib_30min_R2 3 LSDGEINAQESTYK 14 0 A0A3B3IRW6;Q2KHR3-2;Q2KHR3 A0A3B3IRW6 QSER1 Glutamine and serine-rich protein 1 1 LS(1)DGEINAQESTYK;LS(1)DGEINAQESTYK;LS(1)DGEINAQESTYK 205.12 1.5849e-05 8844400.0 40849.5 31990.6 38323.4 40501.7 43034.0 38625.4 49175.5 44839.9 44814.0 35165.9 True False 38579.24832350487 34444.17615400836 35857.714167362996 34985.298590670456 37627.68419115875 43945.69824352913 51462.25818940466 44970.376685354975 53778.05220777964 34150.56909501897 1.1296809788488078 1.0085974280010526 1.0499887737622804 1.0244426232935966 1.1018171933376928 1.286821842448852 1.5069224189564294 1.3168265676695305 1.5747337052612527 1.0 15.059621999755025 -6.804615192964026 3.0609310311668487 1.3783673927584104 1.051490882936217 0.4702531766367838 0.14563227677559049 0.1926148356009413 3.690912177448742 0.050192369338930294 0.045516718973862155 1.5681399065730157e-07 6.804615192964026 -0.3268765098221933 LS(ph)DTPAPK ddPTM_A459_Selumetinib_30min_R1 1 LSDTPAPK 8 0 I3NI13;I3L270;J3KNE2;H3BNM4;Q8NBZ0-2;Q8NBZ0 I3NI13 INO80E INO80 complex subunit E 1 LS(0.5)DT(0.5)PAPK 116.52 0.0093122 10472000.0 4197.4 4975.6 5276.8 4591.6 3559.3 4263.4 4123.9 3631.6 2589.0 3567.9 True False 4295.191253281354 4393.054438906315 4560.239543387611 3789.7632550067833 3237.361943445456 4220.514066857476 3812.8309028290632 3535.2781709007027 4393.343906921536 4025.8747192890373 1.066896402091687 1.091204954257027 1.1327326013246983 0.9413515122189517 0.804138769627975 1.048347095014127 0.9470813596262138 0.8781391417776226 1.0912768561505046 1.0 11.975086562566487 -5.76803025152839 24.981520659093793 0.9503629226086717 1.0963706895025869 0.3949299361822959 0.07799284905128065 141.83391660281413 537598.4754301419 0.021601715503002404 0.03288873571398823 1.705963553041648e-06 5.76803025152839 0.14600776689391515 LS(ph)ESQLSFR ddPTM_A459_Selumetinib_30min_R2 1 LSESQLSFR 9 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 LS(0.847)ES(0.153)QLSFR 105.2 0.013882 4359100.0 8616.1 5882.7 7910.1 7925.4 7538.7 4246.9 6407.2 5860.6 3732.0 8037.6 True False 8137.251654981098 6333.884174138182 7401.172777865692 6845.946847922421 6591.621109166904 4831.871925480225 6705.147495625942 5877.653375725444 4478.50428079247 7805.5336038072255 1.0424978057889691 0.811460752798344 0.9481956203808665 0.8770632727252936 0.844480524169645 0.6190315961388511 0.8590248708115792 0.7530110911134328 0.5737601691456476 1.0 12.930281546109642 -6.449684798468005 3.4338824297595782 0.7501916641216908 0.9135727743182581 0.25993237852928486 0.12396536323288163 0.32659117220440476 7.4600340727491785 0.03890189082167573 0.04330720317671287 3.550709985817026e-07 6.449684798468005 0.16338111019656731 LS(ph)FADR ddPTM_A459_Selumetinib_30min_R1 1 LSFADR 6 0 A0A087X0I9;Q04759-3;Q04759-2;Q04759 A0A087X0I9 PRKCQ Protein kinase C;Protein kinase C theta type 1 LS(1)FADR 101.25 0.030721 6255600.0 4725.6 6503.7 4210.0 3578.3 4281.5 4064.0 5706.4 5944.8 2906.0 6004.0 True False 4835.697285583065 5742.243780511896 3638.305123874669 2953.4170780100103 3894.239080960219 4023.119849816763 5275.961653751004 5787.124592568147 4931.2697541575835 6774.671883912498 0.7137906260916006 0.8476047074911095 0.5370452158006921 0.4359498332344854 0.5748232752360583 0.5938471882852778 0.7787774440087036 0.854229502436947 0.7278979467430213 1.0 12.725935359111558 -7.391203930940299 3.486292173961201 0.8405681682583113 0.6137420475959466 0.4617316156081389 0.11955711582245895 0.26889871772665463 5.981759207513745 0.06002739697209041 0.038190361247599586 4.0625252104679127e-08 7.391203930940299 -0.22682612066236463 LS(ph)GPAELR ddPTM_A459_Selumetinib_30min_R1 1 LSGPAELR 8 0 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5;Q96PC5-5;Q96PC5-8;Q96RT6 G3V599 MIA2;CTAGE1 Melanoma inhibitory activity protein 2;cTAGE family member 2 1 LS(1)GPAELR 87.806 0.031954 3294200.0 1739.9 2573.5 1384.9 1590.2 1987.6 1831.4 2363.4 2138.8 1163.5 2593.6 True False 1780.436284743944 2272.193423612307 1196.8381867111702 1312.5014217509772 1807.821930939282 1812.9777787781557 2185.1268352157435 2082.0720761984862 1974.3745213222123 2926.5138238033715 0.6083813000514189 0.7764164327982934 0.4089637906291278 0.44848632221569934 0.617739071052735 0.6195008422758665 0.7466654752978058 0.7114513040271829 0.6746506731877538 1.0 11.514967378121048 -8.963311138431415 0.44122357241423904 1.0257392836822128 0.5663838595553348 0.5841383064425569 0.10264602412412431 1.5601864935349137 0.5936961147167589 0.2102986294983076 0.0715239363568116 1.088150238466801e-09 8.963311138431415 -0.459355424126878 LS(ph)GPAELR ddPTM_A459_Selumetinib_30min_R2 2 LSGPAELR 8 0 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5;Q96PC5-5;Q96PC5-8;Q96RT6 G3V599 MIA2;CTAGE1 Melanoma inhibitory activity protein 2;cTAGE family member 2 1 LS(1)GPAELR;LS(1)GPAELR 97.597 0.020141 16995800.0 84403.0 33504.0 61393.0 68432.0 44000.0 42929.0 123534.0 86305.0 88810.0 43988.0 True False 79712.21915197931 36073.64906766038 57443.04121964432 59111.44354821547 38472.32663500916 48842.08007933804 129278.57577797704 86556.13326143802 106574.48155872963 42717.95214545045 1.8660121833688796 0.844461104896441 1.344704938665046 1.3837611725147028 0.9006126160733232 1.1433619269256057 3.026328962067192 2.0262238453454615 2.4948406046210723 1.0 15.382554866920934 -7.229443459555576 24.899151974190065 2.2223671302497503 1.2237399312838804 0.38674960571768036 0.5441256923567538 549.2313533944435 427411.072778706 0.19383328250826715 0.15012942927287 5.8959873144710704e-08 7.229443459555576 -0.9986271989658699 LS(ph)HQT(ph)VLMT(ph)R ddPTM_A459_Selumetinib_30min_R1 2 LSHQTVLMTR 10 0 J3KNY7;Q9NXS3-2;Q9NXS3 J3KNY7 KLHL28 Kelch-like protein 28 3 LS(1)HQT(1)VLMT(1)R;LS(1)HQT(1)VLMT(1)R 96.23 0.017275 9185500.0 964.98 1010.5799999999999 940.03 1035.44 926.54 815.1800000000001 840.75 779.49 511.43999999999994 631.53 True False 987.4621564757798 892.2608237941037 812.3790892151791 854.6198416160432 842.7346205939236 806.9800293242197 777.3315506082921 758.8153930596396 867.8763259003277 712.5930271231274 1.3857308714657943 1.2521324091484995 1.1400323302276854 1.1993098572214562 1.1826310229223016 1.1324556915497062 1.0908492239203158 1.0648650269889963 1.2179130202888855 1.0 9.47693455623204 -1.5228787452803376 0.43017392126895465 1.1006408154434189 6.4970373540692465 0.6852294074568118 0.05749252487530304 47.970689627978196 0.6026992531544869 0.037360190547911766 224.38402117227398 0.029999999999999995 1.5228787452803376 5.396396538625828 LS(ph)LDLSHR ddPTM_A459_Selumetinib_30min_R1 2 LSLDLSHR 8 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1 Q8TDM6-4 DLG5 Disks large homolog 5 1 LS(1)LDLSHR;LS(1)LDLSHR 84.65799999999999 0.024056 9536400.0 10178.9 13334.400000000001 8058.9 7466.3 8815.0 9796.4 11239.1 10353.5 5654.2 9403.900000000001 True False 10416.04856530842 11773.202249005619 6964.545644369015 6162.4508648090305 8017.68480641465 9697.857110419518 10391.325638348677 10078.891547092311 9594.764433571165 10610.98216674296 0.9816290708653245 1.1095299251284485 0.6563525915817066 0.5807615890754619 0.755602514491425 0.9139452840486937 0.9792991332053377 0.9498547249171398 0.9042296257591653 1.0 13.373270579770947 -6.92138293856115 5.59601122558475 0.9532536493336021 0.811613765440949 0.1818805848984183 0.14267916566440772 0.4205885083898495 22.36969553668871 0.05825639524054348 0.05114986250996491 1.1984421124479307e-07 6.92138293856115 -0.14163988389265314 LS(ph)LDLSHR ddPTM_A459_Selumetinib_30min_R2 4 LSLDLSHR 8 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1 Q8TDM6-4 DLG5 Disks large homolog 5 1 LS(1)LDLSHR;LS(1)LDLSHR;LS(1)LDLSHR;LS(1)LDLSHR 89.679 0.019402000000000003 6250200.0 127318.0 97515.0 115287.0 122340.0 124710.0 125736.0 142783.0 141857.0 151445.0 117691.0 True False 120242.17525433606 104994.08693985504 107869.55993499466 105677.08095172861 109042.81487845433 143054.99268223456 149422.69241914686 142269.7803843093 181738.23172685306 114292.95503205863 1.0520523790867837 0.9186400588768109 0.9437988536103363 0.924615877873546 0.9540641839898911 1.2516518856486676 1.3073657285108649 1.2447817133121049 1.5901087838342822 1.0 16.802376953636184 -6.800125901616436 4.298476784093315 1.3021281281307369 0.9517483722023365 0.5735265802362138 0.1378094053929005 0.14063440440575936 5.648849430771806 0.04674505466133304 0.04243469323320891 1.5844337998080016e-07 6.800125901616436 -0.3503797559284003 LS(ph)LEGDHSTPPSAYGSVK ddPTM_A459_Selumetinib_30min_R2 3 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LS(1)LEGDHSTPPSAYGSVK;LS(0.938)LEGDHS(0.058)T(0.004)PPSAYGSVK;LS(1)LEGDHSTPPSAYGSVK 306.07 1.8989e-96 107638000.0 455840.0 296253.0 454100.0 574530.0 542620.0 347678.0 525320.0 580280.0 509440.0 394645.0 True False 430506.23767210025 318974.6524964654 424883.70038669684 496278.0228804704 474451.22451565147 395567.4885933536 549748.4209018328 581968.5187294745 611342.2349429041 383250.57343914936 1.1233022662142316 0.8322874761389252 1.108631610316841 1.2949178873420968 1.2379661177231938 1.032138021461199 1.4344360034965977 1.5185065830615818 1.595150215841673 1.0 18.547928424956737 -6.1719572183213645 0.6866159183073198 1.3972437727127813 0.961262609889313 0.2967963095869982 0.19441090400511982 0.9851256498912049 0.9661221250275144 0.12212216240791927 0.25309856734600555 6.730429534406637e-07 6.1719572183213645 -0.4359811628234683 LS(ph)LGLSR ddPTM_A459_Selumetinib_30min_R2 1 LSLGLSR 7 0 Q9NR12-2;Q9NR12;D6RAN1;H0Y8W6;D6RF83;H7BYK4;D6RH06;Q9NR12-3;Q9NR12-5;Q9NR12-6;Q9NR12-4 Q9NR12-2 PDLIM7 PDZ and LIM domain protein 7 1 LS(1)LGLSR 93.598 0.029548 0.0 10736.0 10092.0 10161.0 12381.0 10887.0 8536.6 9089.3 9532.0 7358.0 11924.0 True False 10139.336099613174 10866.023949105427 9507.252322460314 10694.68644158371 9519.277728985115 9712.439162460741 9511.970460106264 9559.73654189245 8829.805599697478 11579.723137727357 0.8756112714455733 0.9383664721398511 0.8210258750906727 0.9235701332737266 0.822064363350001 0.838745369551807 0.8214333233163197 0.825558299468 0.7625230322588197 1.0 13.499313139560302 -6.2773401432743166 24.644887278920706 0.8348355059967452 0.8882224021112073 0.09086991736033578 0.06433566942049034 1313.9549059196836 2036518.4885849054 0.018644781447221342 0.021207443805628612 5.280315308223745e-07 6.2773401432743166 0.05338689611446212 LS(ph)LQGHPTDLQTSNVK ddPTM_A459_Selumetinib_30min_R2 1 LSLQGHPTDLQTSNVK 16 0 Q9P270;D6RIF6 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 LS(0.999)LQGHPT(0.001)DLQTSNVK 101.05 0.0037591 9289500.0 54744.0 54742.0 64711.0 56595.0 59108.0 94768.0 57749.0 46758.0 54988.0 74984.0 True False 51701.54763759538 58940.535376727064 60547.56471200961 48886.66336817951 51682.32460777551 107821.43178174902 60434.44292747264 46894.05803879638 65987.13649309128 72819.01708817076 0.7100006249053608 0.809411301245122 0.8314801151284064 0.6713447300309826 0.7097366412567405 1.4806768354370483 0.8299266502635895 0.6439809257795404 0.9061799943439597 1.0 16.152027646951048 LS(ph)NGSFSAPSLTNSR ddPTM_A459_Selumetinib_30min_R2 2 LSNGSFSAPSLTNSR 15 0 O94806;O94806-2 O94806 PRKD3 Serine/threonine-protein kinase D3 1 LS(0.998)NGS(0.001)FS(0.001)APSLTNSR;LS(0.999)NGS(0.001)FSAPSLTNSR 172.42 3.9202e-05 38386000.0 55696.0 55637.0 54849.0 62806.0 62473.0 43098.0 41632.0 49517.0 38297.0 52834.0 True False 52600.63928875333 59904.17899884851 51320.07505507588 54251.71445360689 54624.583224293856 49034.35829530876 43567.970492242996 49661.08627201935 45957.470107585505 51308.54514078221 1.0251828256760316 1.16752831004039 1.0002247172330074 1.057362166569898 1.0646293531499087 0.9556762555002591 0.8491367348791443 0.9678911404670995 0.8957079172969291 1.0 15.646911497888446 -6.8256620512955495 4.124351893390784 0.9228938303048341 1.065634978830985 0.5783613905609442 0.0553925650920281 0.14689347984057916 4.9611063545545475 0.01919922283611835 0.01720754044720166 1.493956488062031e-07 6.8256620512955495 0.14274114852615083 LS(ph)NIFVIGK ddPTM_A459_Selumetinib_30min_R2 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 LS(1)NIFVIGK 85.522 0.03506 7182400.0 6790.2 6464.5 6348.7 7754.1 8975.3 6137.0 5307.7 6940.7 4060.5 6925.2 True False 6412.827867324275 6960.30636335633 5940.231553941917 6697.978203431408 7847.742573799952 6982.316043860729 5554.518567008023 6960.896287905258 4872.71345984936 6725.251482169531 0.9535446941019862 1.0349510916892837 0.8832727771877504 0.995944645518397 1.166906931972202 1.0382237842514508 0.8259198309140647 1.035038809531582 0.724539962969154 1.0 12.715372501074148 -7.245457104016404 24.765642653065115 0.8992945478756856 1.013618514072872 0.226053322802663 0.10486190514049154 1141.5395198364538 1768896.4296227947 0.03982782981778899 0.030749485784216917 5.6825451622563475e-08 7.245457104016404 0.11432396619718632 LS(ph)PAALHNGLLAR ddPTM_A459_Selumetinib_30min_R2 1 LSPAALHNGLLAR 13 0 Q9HCM7;A0A3B3IRR3 Q9HCM7 FBRSL1 Fibrosin-1-like protein 1 LS(1)PAALHNGLLAR 106.55 0.0056258 0.0 16151.0 11083.0 12127.0 12843.0 11739.0 9922.5 11271.0 11276.0 8872.9 11283.0 True False 15253.392077575681 11933.030462538201 11346.762022879266 11093.761244589252 10264.241872008472 11289.234307513138 11795.1238330628 11308.811293157705 10647.727929540055 10957.23047324536 1.392084625291072 1.089055349495065 1.0355501831037541 1.012460335819098 0.9367551314240418 1.030299977268749 1.0764694474450778 1.0320866500682644 0.9717535791128035 1.0 13.419595571330595 -4.621857129041038 1.9416883261829452 1.0123651184476918 1.6391498654987988 0.9090913339570025 0.03598429235569613 0.38841916300079365 1.091726762943571 0.010450910143010009 0.5061466237873465 2.3885969364788813e-05 4.621857129041038 0.626784747051107 LS(ph)PANQR ddPTM_A459_Selumetinib_30min_R2 2 LSPANQR 7 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 LS(1)PANQR;LS(1)PANQR 99.013 0.021486 52995000.0 202021.0 142369.0 162732.0 199404.0 189364.0 132102.0 169289.0 154539.0 141335.0 175943.0 True False 190793.48157413854 153288.24451151313 152262.00028920497 172244.83120891347 165574.40138436068 150297.85139744022 177161.2739397896 154988.68290469117 169605.94922985052 170863.0684351861 1.1166455297887423 0.8971408854784808 0.8911346476664901 1.0080869598467472 0.9690473365645332 0.8796391916281958 1.0368611284011477 0.9070929389488483 0.9926425340663219 1.0 17.382481070729618 -8.495764399446657 24.18618067167757 1.0000001054836907 0.9593309815022217 0.031654154983009386 0.0712939592229975 1438.4087970739554 1283071.2898239046 0.06533683493166535 0.01686989826759573 3.1932697032124924e-09 8.495764399446657 -0.040669123981468935 LS(ph)PCLHR ddPTM_A459_Selumetinib_30min_R2 1 LSPCLHR 7 0 D6RFX7;Q9C073;K7ENS5;D6RJ87 D6RFX7 FAM117A Protein FAM117A 1 LS(1)PCLHR 90.709 0.019377 1591500.0 12993.0 9249.7 9628.4 11878.0 13217.0 9293.1 12876.0 11903.0 11844.0 10965.0 True False 12270.901075100033 9959.122247526811 9008.91922660928 10260.195909307107 11556.562298520825 10573.140170637473 13474.759513309968 11937.635759352279 14213.130949010176 10648.411959508598 1.152369115860757 0.9352683090583964 0.8460340622495058 0.9635423524486363 1.0852850493074027 0.9929311723515815 1.2654243247301826 1.1210719311711506 1.3347653155284276 1.0 13.37835067113009 -7.246123046211824 23.50028404554269 1.1904047092444863 0.9889281472030904 0.3882764323912954 0.1129092932153294 352.02017127130154 540114.9564863757 0.042733553723373105 0.03294891834514498 5.673838289660346e-08 7.246123046211824 -0.20147656204139586 LS(ph)PDFAEELR ddPTM_A459_Selumetinib_30min_R1 2 LSPDFAEELR 10 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LS(1)PDFAEELR;LS(1)PDFAEELR 160.86 0.00043512 11683500.0 2163.7 2682.1 1582.38 1310.99 2375.8 1865.41 2045.45 2523.8999999999996 1133.27 2230.9 True False 2214.1100001726936 2368.078485125539 1367.5014873911641 1082.050206830156 2160.9093094815576 1846.6456690567647 1891.1600596987575 2456.95797321739 1923.076419234055 2517.2577458061933 0.879572226507774 0.9407373913421498 0.5432504834554395 0.4298527668185252 0.8584378429589421 0.7335941947674278 0.751277878814544 0.9760454515675783 0.7639568981118213 1.0 11.297637228438964 -7.656525051469614 6.307515756404753 0.9014915772602528 0.7257115714411386 0.216932226683347 0.15581424649709066 0.3686694294425856 19.30994547903726 0.08034820960837534 0.045663889146286836 2.2053369219642232e-08 7.656525051469614 -0.17578000581911413 LS(ph)PDFAEELR ddPTM_A459_Selumetinib_30min_R2 2 LSPDFAEELR 10 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 LS(1)PDFAEELR;LS(1)PDFAEELR 132.17 0.0024854 7821800.0 18534.5 9552.0 13357.400000000001 14006.2 11335.3 10926.900000000001 21828.0 20094.2 14068.4 10618.1 True False 17504.426689482156 10284.607685479106 12497.999426437502 12098.531397957333 9911.258275132257 12431.981290477741 22843.045251361462 20152.670795226102 16882.47310393912 10311.52786386304 1.697558976766845 0.9973893123560984 1.2120414735276035 1.1733015279294239 0.9611823200193701 1.205639111352826 2.2152920064751394 1.954382615388312 1.6372426401623847 1.0 13.331970492886756 -7.169671601700949 9.769147752715055 1.7808256092665309 1.1844865928734114 0.3174120972258946 0.3461847046763014 0.4358997451678081 43.868628742305425 0.12681949431292763 0.09821700649048934 6.765943990299383e-08 7.169671601700949 -0.5963390163931195 LS(ph)PENNQVLTK ddPTM_A459_Selumetinib_30min_R1 2 LSPENNQVLTK 11 0 Q16514-2;Q16514 Q16514-2 TAF12 Transcription initiation factor TFIID subunit 12 1 LS(1)PENNQVLTK;LS(1)PENNQVLTK 201.3 1.8773e-05 50017000.0 6125.8 9858.5 4764.3 4826.3 5526.1 5897.7 8167.700000000001 7107.299999999999 3317.6000000000004 7054.2 True False 6268.519221268145 8704.26223690769 4117.334228426624 3983.477305871423 5026.265230712197 5838.374492683149 7551.603813147007 6918.791316235975 5629.7248920830025 7959.675283726768 0.7875345410237874 1.0935448905438643 0.5172741451958909 0.5004572628754693 0.6314661153311356 0.7334940540375394 0.9487326485021259 0.8692303479240117 0.7072807233220614 1.0 12.958493861648028 -7.124425033892175 6.052062069968752 0.8695504499469806 0.7036233192725831 0.1940436547259038 0.17030548496477887 0.47444099270743323 21.45614642028117 0.07163771754644097 0.05538942145634352 7.508876580393791e-08 7.124425033892175 -0.16592713067439746 LS(ph)PENNQVLTK ddPTM_A459_Selumetinib_30min_R2 4 LSPENNQVLTK 11 0 Q16514-2;Q16514 Q16514-2 TAF12 Transcription initiation factor TFIID subunit 12 1 LS(1)PENNQVLTK;LS(1)PENNQVLTK;LS(1)PENNQVLTK;LS(1)PENNQVLTK 162.88 0.00055759 107687000.0 227720.0 177553.0 226112.0 238039.0 233252.0 190709.0 247882.0 257047.0 215692.0 171835.0 True False 215064.23403538705 191170.74417712202 211564.20009213156 205617.67755982082 203948.7984606628 216977.4336660643 259409.00416886483 257794.9642135786 258836.42693801978 166873.6770690527 1.2887846532343923 1.145601556427711 1.2678105007812934 1.2321756263256294 1.2221747734141937 1.30024961082555 1.554523210161665 1.544850983938602 1.551092008543161 1.0 17.34839687397269 -7.066780378317612 4.909891939391833 1.4570451739743202 1.2308576649937686 0.20814814860339248 0.15725337935437686 0.25867111907862045 12.106649122155783 0.0571988319794295 0.04469826331960417 8.574713568257161e-08 7.066780378317612 -0.22618750898055162 LS(ph)PEPGR ddPTM_A459_Selumetinib_30min_R1 1 LSPEPGR 7 0 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 LS(1)PEPGR 101.25 0.020043 22044000.0 9050.3 12584.0 7011.2 6475.1 7911.1 8211.3 10254.0 9897.5 5265.4 10046.0 True False 9261.154381181743 11110.65942985712 6059.117549764863 5344.345337680639 7195.542401818144 8128.701777263879 9480.532524457243 9634.986148389058 8934.99923039963 11335.501956326598 0.8170043476559841 0.980164749003992 0.5345257380845966 0.4714696674458108 0.6347793357136823 0.717101175455849 0.8363575394352912 0.8499831931140515 0.7882314576649874 1.0 13.468560657162698 -7.252288466231168 3.0365761583370223 0.861385006321898 0.6827143597577708 0.27331318168034413 0.14151021135275355 0.4354327538115928 8.186311397218102 0.07011634393967092 0.048297724368558115 5.5938592384725234e-08 7.252288466231168 -0.17867064656412712 LS(ph)PEPGREGVR ddPTM_A459_Selumetinib_30min_R1 1 LSPEPGREGVR 11 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 LS(1)PEPGREGVR 125.23 0.016094 105000000.0 4079.2 5589.4 4958.9 4744.7 5852.3 4468.3 5082.2 4543.3 2598.8 4123.9 True False 4174.237423258517 4934.990449558433 4285.508617287906 3916.1272140497163 5322.960498307484 4423.352958891791 4698.845562297308 4422.796925281736 4409.973791157854 4653.242735187666 0.8970598915231894 1.060548681941778 0.9209725048042376 0.841591001568883 1.14392495754744 0.9505957910689988 1.009800225284788 0.9504762972790337 0.94772055577711 1.0 12.184020731528895 -6.212193670252769 24.99999672760651 0.9959221050070702 0.9387170601952246 0.17279243030989644 0.07408368306710222 868.9059401556893 441107.07783147966 0.022010188249710124 0.02841499849445873 6.134883637818964e-07 6.212193670252769 -0.05720504481184563 LS(ph)PEVAPPAHR ddPTM_A459_Selumetinib_30min_R1 3 LSPEVAPPAHR 11 0 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 LS(1)PEVAPPAHR;LS(1)PEVAPPAHR;LS(1)PEVAPPAHR 98.368 0.012117 56359400.0 16887.1 22230.3 14062.199999999999 15476.5 15119.6 14756.300000000001 17768.0 16080.8 8066.800000000001 15360.3 True False 17280.536573423433 19627.566141413918 12152.630478135476 12773.819804885547 13752.03484958218 14607.865019648403 16427.745454901138 15654.284946200032 13688.770424238946 17331.944126992184 0.9970339418825676 1.1324503470355993 0.7011694931100879 0.7370102113929637 0.7934502182109637 0.84282899325175 0.9478305107917537 0.9032042124934258 0.7898000549702049 1.0 14.081145870461736 -5.251221887062986 24.996625792012335 0.8346501853869778 1.0647421575439966 0.48769969655357936 0.09227424002073854 588.1956138660387 1438986.7027196637 0.0244046255736102 0.0629793318614586 5.60761402068151e-06 5.251221887062986 0.23009197215701882 LS(ph)PEVAPPAHR ddPTM_A459_Selumetinib_30min_R2 4 LSPEVAPPAHR 11 0 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 LS(1)PEVAPPAHR;LS(1)PEVAPPAHR;LS(1)PEVAPPAHR;LS(1)PEVAPPAHR 111.12 0.005575 113003400.0 344021.0 283539.0 338669.0 339850.0 348821.0 279113.0 347333.0 369521.0 329619.0 291878.0 True False 324901.6900451771 305285.52957841964 316879.40525492653 293561.8437260498 304998.98748069414 317558.28221445344 363484.6727272827 370596.2449325053 395552.010324365 283450.7237498813 1.14623693934143 1.0770321046976952 1.1179347191737738 1.0356715264029124 1.076021198484669 1.120329763188994 1.282355775700978 1.3074450473427675 1.3954877415426976 1.0 18.112738427309203 -7.1970776700469505 4.209996654301145 1.2725634499346636 1.0894440466777209 0.34729872508936876 0.09911830318595535 0.20949987143314155 7.435386934965375 0.03775819805361792 0.028231943874637858 6.352173182254077e-08 7.1970776700469505 -0.18311940325694276 LS(ph)PEVQSVAESK ddPTM_A459_Selumetinib_30min_R2 2 LSPEVQSVAESK 12 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 LS(1)PEVQSVAESK;LS(1)PEVQSVAESK 152.11 0.00050463 10870200.0 51896.0 29577.0 35823.0 46795.0 44027.0 45601.0 67167.0 66328.0 59630.0 35341.0 True False 49011.82807614805 31845.460794955543 33518.18718113334 40421.44027412241 38495.93465362611 51882.12382533705 70290.39858888554 66521.00349880847 71557.66620140796 34320.613503054534 1.4280580407394523 0.9278814550363821 0.9766196976097243 1.1777598401766596 1.1216563669585908 1.5116898717652452 2.048051926071476 1.9382230301007906 2.0849763129974157 1.0 15.06678772171976 -6.938025600515183 3.17390779873703 1.8442611560138027 1.1082110572903408 0.47518705260191196 0.3138173577963415 0.18641072605643372 3.8190548705831535 0.11457744544650598 0.09691266257832762 1.1533852667952814e-07 6.938025600515183 -0.7360500987234619 LS(ph)PGEALPPVSQAGTGK ddPTM_A459_Selumetinib_30min_R2 1 LSPGEALPPVSQAGTGK 17 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 LS(1)PGEALPPVSQAGTGK 176.68 9.2631e-08 4075700.0 29381.0 25763.0 28764.0 28493.0 27814.0 25078.0 31718.0 30303.0 27019.0 28262.0 True False 27748.12164146188 27738.939258898474 26913.35555587525 24612.204246833437 24319.756659685107 28532.26686458195 33192.949848024684 30391.17671306828 32423.554973936672 27446.002626505408 1.0110077601852558 1.0106731984391115 0.9805929089974011 0.8967500507000867 0.8860946707116761 1.0395782312221855 1.2093910468393412 1.1073079430415353 1.1813580073997478 1.0 14.744308422737534 -7.008924513062748 6.833707857548384 1.1326718454002744 0.9581061494396661 0.599220265931612 0.06445106871052513 0.09736319656485615 24.189338533092492 0.0240152529872168 0.019823041255087465 9.796602503518467e-08 7.008924513062748 -0.17456569596060834 LS(ph)PGESAYQK ddPTM_A459_Selumetinib_30min_R1 1 LSPGESAYQK 10 0 A0A0G2JHC2;Q6NYC8;Q6NYC8-2 A0A0G2JHC2 PPP1R18 Phostensin 1 LS(0.998)PGES(0.002)AYQK 160.72 0.00043736 34094000.0 5215.6 6209.0 5132.3 5296.7 5322.6 4594.2 5252.4 5233.5 3147.8 4218.3 True False 5337.113332209041 5482.047393514209 4435.36184970593 4371.730776373033 4841.1717697813565 4547.986519199848 4856.207239268502 5094.690579196172 5341.586693784319 4759.759894721535 1.1212988575595542 1.1517487257274626 0.9318457123487773 0.918477165459792 1.0171041978714317 0.9555075507576467 1.0202630692892567 1.070367138654634 1.1222386868102354 1.0 12.216673083524844 -10.387493185473804 12.763231593910879 1.0000148137419804 1.0291725551042754 0.013238488372070645 0.07826110954442542 0.0 0.0 0.08273321375046477 0.020065751708233513 4.0973853898134734e-11 10.387493185473804 0.029157741362294987 LS(ph)PGESAYQK ddPTM_A459_Selumetinib_30min_R2 3 LSPGESAYQK 10 0 A0A0G2JHC2;Q6NYC8;Q6NYC8-2 A0A0G2JHC2 PPP1R18 Phostensin 1 LS(1)PGESAYQK;LS(1)PGESAYQK;LS(1)PGESAYQK 168.85 0.00025321 90819000.0 204134.0 178933.0 200833.0 206519.0 202657.0 158869.0 164966.0 164694.0 158215.0 192004.0 True False 192789.04949314802 192656.58573972236 187911.623430437 178390.7559348541 177197.41588343302 180751.76268080686 172637.24587392775 165173.23227344066 189862.42089645786 186460.34563369726 1.0339412856816406 1.0332308732184678 1.0077833053017653 0.9567222206340005 0.9503222536739188 0.9693844665283151 0.9258657399095189 0.8858357079200352 1.0182455698620445 1.0 17.508509320785983 -5.649775700762369 2.443377267451863 0.9511656604272791 1.0334985358100868 0.4394158466103999 0.0348583758645712 0.2426190497201289 2.921884962114359 0.009983205144257117 0.020327943177378124 2.239877665207373e-06 5.649775700762369 0.08233287538280765 LS(ph)PGSYPTVIQQQNATSQR ddPTM_A459_Selumetinib_30min_R2 1 LSPGSYPTVIQQQNATSQR 19 0 Q13469-5;Q13469-3;Q13469-4;Q13469-2;Q13469 Q13469-5 NFATC2 Nuclear factor of activated T-cells, cytoplasmic 2 1 LS(0.995)PGS(0.005)YPTVIQQQNATSQR 203.17 1.0839000000000001e-15 4593100.0 10780.0 17429.0 11939.0 13381.0 12882.0 8989.9 7705.2 7476.4 10367.0 11918.0 True False 10180.89075575913 18765.748256932075 11170.85773820035 11558.484716487492 11263.647993458822 10228.177122813031 8063.507067564151 7498.155086215347 12440.68967818207 11573.89637331723 0.8796424667522018 1.621385543091187 0.9651769272752384 0.9986684124055865 0.9731941284204287 0.8837280715933611 0.6966977072780759 0.6478505461222026 1.0748920913844684 1.0 13.498587011682769 -5.849301077425571 1.3441090426685744 0.8431223740206257 1.2402104646327594 0.2592623557551592 0.21619091094372733 0.5111068548783426 1.865091624137076 0.07302364276446176 0.15967856167565161 1.4148126120092043e-06 5.849301077425571 0.3970880906121337 LS(ph)PGTDSSSNLGGVK ddPTM_A459_Selumetinib_30min_R1 2 LSPGTDSSSNLGGVK 15 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;A0A1W2PRR3;I3L233;A0A1W2PPV8 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 LS(0.994)PGT(0.006)DSSSNLGGVK;LS(0.619)PGT(0.381)DSSSNLGGVK 258.96 2.6725e-36 40582000.0 6137.299999999999 7324.1 4844.0 5724.200000000001 5133.1 4952.9 6052.799999999999 5811.299999999999 3099.7 5502.4 True False 6280.287148893039 6466.590967118284 4186.211406187386 4724.575926541909 4668.812011322412 4903.078322873385 5596.232422862764 5657.165446237263 5259.964506869324 6208.686637914744 1.011532311929072 1.041539272996738 0.6742507152194384 0.7609622134398315 0.7519806174161311 0.7897126411456543 0.9013552703220854 0.911169426991291 0.84719439289272 1.0 12.600072403130298 -9.656150602003251 11.506395849954098 0.9999886131028938 0.8500017868516487 0.13489008052496088 0.11010207843023014 0.0 0.0 0.11619869598850503 0.02818232335997891 2.2072391872886584e-10 9.656150602003251 -0.14998682625124504 LS(ph)PGTDSSSNLGGVK ddPTM_A459_Selumetinib_30min_R2 2 LSPGTDSSSNLGGVK 15 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;A0A1W2PRR3;I3L233;A0A1W2PPV8 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 LS(0.988)PGT(0.012)DSSSNLGGVK;LS(1)PGTDSSSNLGGVK 221.78 1.5869e-09 70143000.0 89030.0 78419.0 89614.0 94232.0 88774.0 77023.0 81958.0 86259.0 60724.0 79387.0 True False 84082.06901532793 84433.48514317283 83848.33280434608 81397.43904073325 77621.41647037059 87632.21910482079 85769.20939669611 86509.9994090539 72870.49677032202 77094.89103780276 1.0906308820658306 1.0951891105439355 1.0875990830991877 1.055808471158235 1.0068295761947397 1.1366799787271396 1.1125148274045809 1.1221236354901198 0.9452052631424129 1.0 16.23434763763214 -8.263716405572428 24.999781586031943 0.9726026217405006 1.0872249254648398 0.616744055282699 0.03651042546940977 143.58859091955506 1576424.6735461436 0.03183113570632714 0.00976311237061184 5.448583293546279e-09 8.263716405572428 0.11462230372433924 LS(ph)PIPEEVPK ddPTM_A459_Selumetinib_30min_R1 3 LSPIPEEVPK 10 0 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 LS(1)PIPEEVPK;LS(1)PIPEEVPK;LS(1)PIPEEVPK 160.72 0.00043736 149773400.0 18566.9 24690.2 15094.599999999999 14410.5 16458.3 16342.699999999999 21821.699999999997 21542.7 10723.400000000001 20959.899999999998 True False 18999.472645101632 21799.459905837426 13044.836228702752 11893.976693587254 14969.649670948871 16178.307275984362 20175.671600248545 20971.31761544844 18196.82659385183 23650.307331715114 0.8033499260123059 0.921741083533587 0.5515715312168311 0.5029100267816564 0.6329579341607345 0.6840632998578084 0.8530828507751747 0.8867249512367164 0.7694118447860442 1.0 14.529571310812235 -7.27397199177271 4.693721401858932 0.8702599314783588 0.6763606032960898 0.3749793807004068 0.12295831554466834 0.2507047102554405 15.451929978347728 0.05697773707522453 0.039813515864831235 5.3214257674092816e-08 7.27397199177271 -0.19389932818226896 LS(ph)PIPEEVPK ddPTM_A459_Selumetinib_30min_R2 4 LSPIPEEVPK 10 0 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 LS(1)PIPEEVPK;LS(1)PIPEEVPK;LS(1)PIPEEVPK;LS(1)PIPEEVPK 150.09 0.00072349 143640000.0 652063.0 446388.0 565050.0 595223.0 586754.0 465683.0 645975.0 674700.0 515208.0 491793.0 True False 615823.9488750056 480624.5242363525 528695.2981799232 514152.60058305226 513040.7168726856 529826.6062006191 676014.11747518 676663.2652974022 618263.9961142889 477593.658258331 1.2894307498151611 1.0063461185583458 1.106998154263496 1.076548215606637 1.0742201199731618 1.1093669211035362 1.4154587394238871 1.416817944704354 1.2945397942865253 1.0 18.865424154297486 -7.240083604084687 22.07812504375986 1.316438894340984 1.1024018679867555 0.28153783163200896 0.12893130220694604 178.60477150621836 184645.79707703198 0.046708296742115324 0.03611808100571167 5.753291726350508e-08 7.240083604084687 -0.2140370263542284 LS(ph)PISHGNTIALFFR ddPTM_A459_Selumetinib_30min_R1 1 LSPISHGNTIALFFR 15 0 Q9BQ70 Q9BQ70 TCF25 Transcription factor 25 1 LS(0.999)PIS(0.001)HGNTIALFFR 74.14699999999998 0.027206 9892100.0 1901.4 2447.3 1551.5 1708.0 1846.6 2022.3 1833.7 2465.0 1284.8 2176.7 True False 1945.6989205196464 2160.7689782810958 1340.814821779465 1409.729863130844 1679.5753560437088 2001.957498101486 1695.382532679661 2399.620192551555 2180.211761920737 2456.100647853486 0.7921902232386502 0.8797558765230179 0.545912001998482 0.5739707223980745 0.6838381633552261 0.8150958715193942 0.6902740464489286 0.9770040143300757 0.8876719949673632 1.0 11.262153966373404 -7.760174928178224 24.99991336810623 0.9492535484247818 0.7092954950032662 0.5532736611876521 0.10013813008366995 27.806776042750478 549816.2181934129 0.054712592038409044 0.029334091680484613 1.737101006089191e-08 7.760174928178224 -0.23995805342151566 LS(ph)PLPVVSR ddPTM_A459_Selumetinib_30min_R1 1 LSPLPVVSR 9 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LS(1)PLPVVSR 101.3 0.017151 6661900.0 2157.3 2460.7 1899.0 1453.2 1445.9 1594.5 2737.7 2205.1 1376.3 2461.1 True False 2207.560892624926 2172.6001000516044 1641.1262304603315 1199.4258999424715 1315.1186002943791 1578.4607776901655 2531.193084865083 2146.6135848257336 2335.480579025148 2777.006158144078 0.7949427429791073 0.7823533605354304 0.5909696043155788 0.4319133021815367 0.4735742470133001 0.5684037729124369 0.9114827050137778 0.7729956156310266 0.841006625849901 1.0 11.439314661067701 -7.259156479535391 24.981998595708603 0.86245421113432 0.600240066715202 0.550099394762195 0.12097003482410121 186.64021213389688 2042436.1312676696 0.053970497230996416 0.039771704697350245 5.506092720403572e-08 7.259156479535391 -0.26221414441911794 LS(ph)PLPVVSR ddPTM_A459_Selumetinib_30min_R2 2 LSPLPVVSR 9 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 LS(1)PLPVVSR;LS(0.996)PLPVVS(0.004)R 104.07 0.014676 18293700.0 47522.0 35766.0 42802.0 53986.0 55741.0 49210.0 60001.0 63035.0 55054.0 46263.0 True False 44880.917485638725 38509.13719418398 40048.16591929402 46633.01366895549 48738.317249137435 55988.230816096904 62791.165389725946 63218.42141399398 66066.33833728534 44927.26698429053 0.9989683436860735 0.8571439969328484 0.8914000028823796 1.0379668472881158 1.0848271110321377 1.2461971220211103 1.3976181861158343 1.4071281352613596 1.4705176337654011 1.0 15.455303682048775 -6.585245581136162 1.4169216588848235 1.3538578968265857 0.9193711201439067 0.6388910260732283 0.12789815640662186 0.22897236532314036 0.9519109442342674 0.05246193147913545 0.05523595623456773 2.5986896627649465e-07 6.585245581136162 -0.4344867766826791 LS(ph)PPLHMAPGAGEHHLAR ddPTM_A459_Selumetinib_30min_R2 2 LSPPLHMAPGAGEHHLAR 18 0 Q6ZN04 Q6ZN04 MEX3B RNA-binding protein MEX3B 1 LS(1)PPLHMAPGAGEHHLAR;LS(1)PPLHMAPGAGEHHLAR 119.37 0.00050918 6219900.0 26906.0 22730.0 26952.0 29356.0 32643.0 25771.0 27893.0 33410.0 27653.0 24026.0 True False 25410.67223325187 24473.31791153057 25217.937663118824 25357.662158075393 28542.094507877373 29320.721324154307 29190.07976893095 33507.217568676766 33184.37268937675 23332.30695295518 1.089076716009578 1.0489026207685337 1.0808162996469073 1.0868047557064944 1.2232864313600307 1.2566576199804649 1.2510584498903932 1.4360867802844017 1.4222499625213334 1.0 14.510041338609465 -6.468708397329399 1.399872317197705 1.3097876588783979 1.0646020167576087 0.38850142273823374 0.11400343209693616 0.3750562240739243 1.5040460258766604 0.04571508170463859 0.05326408976130215 3.398533871447114e-07 6.468708397329399 -0.2451856421207892 LS(ph)PQQESSASSK ddPTM_A459_Selumetinib_30min_R2 2 LSPQQESSASSK 12 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 LS(1)PQQESSASSK;LS(1)PQQESSASSK 155.37 0.00042539 12075300.0 57346.0 44489.0 52693.0 52557.0 50796.0 42233.0 52085.0 56185.0 50825.0 39381.0 True False 54158.938894226645 47901.16324531824 49302.78974780051 45398.64593411802 44414.55235799833 48050.21239699697 54507.05570446954 56348.48904807253 60991.42016915251 38243.96820587397 1.4161432883397351 1.252515507477098 1.2891651170295657 1.1870798994949785 1.1613479050841957 1.256412831909447 1.4252458168317816 1.473395457938328 1.594798422612032 1.0 15.22294460511487 -7.257601359370475 21.781854269144816 1.412809564337829 1.2535500585434054 0.08853887171393082 0.1574772275195423 93.18975710290277 528887.0429609794 0.05936683516923439 0.04406258945373877 5.5258442600154156e-08 7.257601359370475 -0.1592595057944235 LS(ph)PSWNPK ddPTM_A459_Selumetinib_30min_R1 1 LSPSWNPK 8 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 LS(0.988)PS(0.012)WNPK 107.45 0.013294 18877000.0 3821.5 4993.7 4299.9 4403.6 4550.7 3617.8 5175.2 5473.0 3042.2 4803.2 True False 3910.5335146554285 4409.035282491853 3715.997197660019 3634.59392580971 4139.089988491341 3581.408216699578 4784.830497422577 5327.838261190532 5162.3912065031645 5419.737507129994 0.7215355927313609 0.8135145432212352 0.685641544958847 0.6706217636976295 0.7637067262106544 0.660808426974188 0.8828528118064466 0.9830435983627319 0.9525168330960172 1.0 12.404007264224195 -7.4639477940628165 3.675314588427641 0.972558189398808 0.7223751126293724 0.8752498193988958 0.044491446746558444 0.08025798808937655 2.1566275750026183 0.021301852086287827 0.013102186074756862 3.4359924900650676e-08 7.4639477940628165 -0.25018307676943563 LS(ph)PSWNPK ddPTM_A459_Selumetinib_30min_R2 2 LSPSWNPK 8 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 LS(0.997)PS(0.003)WNPK;LS(1)PSWNPK 151.83 0.0010877 51554000.0 301470.0 254070.0 298790.0 308250.0 335670.0 246420.0 313710.0 318530.0 276717.0 245364.0 True False 284715.5042800281 273556.35203618853 279566.1766979551 266265.81823909085 293500.13367212575 280362.1182219593 328298.1366045724 319456.86956451973 332068.1321189848 238279.70378776742 1.1948793781178293 1.148047222183227 1.1732689450838039 1.1174506850833184 1.231746258731052 1.176609311515991 1.3777847268812422 1.3406801523014136 1.3936064500682506 1.0 17.862296545177074 -7.235472058895901 21.337112136614337 1.306407779914691 1.172568898675985 0.1655807526532599 0.1074311249684834 157.0296660085627 129029.35380656998 0.0384087257413669 0.029727023090912193 5.814708410606901e-08 7.235472058895901 -0.1338388812387059 LS(ph)PTFPESIEHPLAR ddPTM_A459_Selumetinib_30min_R1 2 LSPTFPESIEHPLAR 15 0 M9T4I7;Q5U5Q3 M9T4I7 MEX3C RNA-binding E3 ubiquitin-protein ligase MEX3C 1 LS(0.991)PT(0.009)FPESIEHPLAR;LS(1)PTFPESIEHPLAR 148.36 0.00020249 7980500.0 2174.41 2787.3 1675.65 1870.03 2646.8 1708.63 2803.8999999999996 2418.5 1124.47 2414.3999999999996 True False 2225.0695223346597 2460.9616202193843 1448.1059336865999 1543.46436531064 2407.397407330493 1691.4427335119137 2592.3995655671574 2354.3535236048424 1908.1434619606248 2724.311758247556 0.8167455562303048 0.9033333328203323 0.5315492726934123 0.5665520330549433 0.8836717750978245 0.6208697401797925 0.951579626567683 0.8642012120959705 0.7004130331941376 1.0 11.41167609313019 -7.265214408912598 24.939717035864344 0.8677318991934325 0.7206032526097793 0.23842895781582285 0.13826724260831594 554.6403615798592 3664204.8704315433 0.05816631194168918 0.04092212330842484 5.4298219784070905e-08 7.265214408912598 -0.1471286465836532 LS(ph)PTFPESIEHPLAR ddPTM_A459_Selumetinib_30min_R2 4 LSPTFPESIEHPLAR 15 0 M9T4I7;Q5U5Q3 M9T4I7 MEX3C RNA-binding E3 ubiquitin-protein ligase MEX3C 1 LS(0.866)PT(0.134)FPESIEHPLAR;LS(0.991)PT(0.009)FPESIEHPLAR;LS(0.909)PT(0.091)FPESIEHPLAR;LS(0.993)PT(0.007)FPESIEHPLAR 117.07 0.0014446 12536300.0 22953.699999999997 18102.3 24330.800000000003 33131.1 26729.5 23177.2 30588.6 32504.9 28906.7 26669.2 True False 21678.025244941404 19490.688201931345 22765.38281737206 28618.587025664645 23371.501245238138 26369.648918326377 32011.030510161032 32599.483877524104 34688.84772068157 25899.190901096812 0.8370155395095125 0.7525597334820961 0.8789997689235908 1.1049992694734208 0.902402755919621 1.0181649696712973 1.235985735322928 1.258706652343473 1.3393795911675574 1.0 14.660619407916561 -6.4704304894529105 0.7131330097680691 1.2345898824343184 0.7967005532002447 0.6131760775507475 0.11641237581367476 0.47895697441725354 0.5408414885679125 0.07851983501183186 0.10977309344266495 3.3850844714462607e-07 6.4704304894529105 -0.43788932923407375 LS(ph)PVPVPR ddPTM_A459_Selumetinib_30min_R2 2 LSPVPVPR 8 0 Q9UKM9-2;Q9UKM9;Q5QPM0;Q5QPM1;Q5QPL9 Q9UKM9-2 RALY RNA-binding protein Raly 1 LS(1)PVPVPR;LS(1)PVPVPR 80.755 0.045381 5133500.0 41669.0 33751.0 46014.0 47461.0 43811.0 41530.0 36409.0 44031.0 36470.0 38382.0 True False 39353.20379422333 36339.5931734302 43053.5093362552 40996.72992520835 38307.07050469062 47250.38052819561 38102.09064306483 44159.12292027557 43765.019056940335 37273.811931587676 1.055786938734685 0.9749363236614452 1.155060539965045 1.099880259106681 1.027720764782507 1.2676562465604246 1.0222214651132913 1.1847224802583967 1.1741492696606028 1.0 15.185874748215838 -5.263628957873098 24.993717487615108 1.1213012255129278 1.0153616288871585 0.1956862039634245 0.081480069367759 262.54710617151704 2996971.753051838 0.020033714497309795 0.04529694433570474 5.449680507686222e-06 5.263628957873098 -0.10593959662576924 LS(ph)QMQSPIPLTETR ddPTM_A459_Selumetinib_30min_R2 1 LSQMQSPIPLTETR 14 0 H3BSW6;Q2VPK5-3;Q2VPK5;Q2VPK5-5 H3BSW6 CTU2 Cytoplasmic tRNA 2-thiolation protein 2 1 LS(0.827)QMQS(0.172)PIPLTETR 131.72 0.00086673 8611500.0 30489.0 26030.0 26886.0 30304.0 28497.0 25254.0 23153.0 22258.0 20374.0 27408.0 True False 28794.54343713731 28026.417300358138 25156.18403126347 26176.542922684173 24916.95209358765 28732.50926701302 24229.660376799133 22322.767094989733 24449.36929712373 26616.659825463896 1.0818240765728935 1.0529652287003173 0.9451292610050491 0.9834646080437687 0.9361412084378014 1.079493424622909 0.9103193464425186 0.8386764996573222 0.9185739103797411 1.0 14.700041915653133 -1.5228787453754895 0.38705830345550013 0.9271572237474773 3.3788442040644804 0.36004856846559485 0.06063863570140985 77.40843360246629 1.0467997504816977 0.048184575079907664 143.19956779004588 0.029999999993427135 1.5228787453754895 2.451686980317003 LS(ph)SAGPR ddPTM_A459_Selumetinib_30min_R1 1 LSSAGPR 7 0 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 LS(0.5)S(0.5)AGPR 93.429 0.025721 3611400.0 2359.5 2732.2 2455.1 2357.3 2333.0 2039.0 2406.4 2728.1 1686.6 2253.9 True False 2414.471759212216 2412.3127538346794 2121.710904898978 1945.6418070013694 2121.980561924603 2018.4895112638728 2224.8833105962462 2655.741925882311 2862.0370156098343 2543.2100198451667 0.9493796188170144 0.9485306895659146 0.8342649204520474 0.7650338712961748 0.8343709506357605 0.7936778699018969 0.8748327087558815 1.04424797997768 1.1253640058338863 1.0 11.312434890252051 -7.763298901312315 4.2397819593025385 1.0691384641244537 0.8513028715687891 0.6857452568065123 0.061992615355449775 0.12171948111099026 5.075457499159816 0.037265679710634124 0.01847425861679431 1.724650500127312e-08 7.763298901312315 -0.21783559255566454 LS(ph)SAGPR ddPTM_A459_Selumetinib_30min_R2 2 LSSAGPR 7 0 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 LS(0.5)S(0.5)AGPR;LS(0.5)S(0.5)AGPR 118.74 0.01065 14420600.0 68399.0 47142.0 62531.0 65523.0 77813.0 60256.0 82829.0 103263.0 75504.0 77819.0 True False 64597.65740289129 50757.63981457872 58507.82353860501 56598.654366520444 68037.4352829539 68555.71705049252 86680.71262254976 103563.47823389003 90606.9097580262 75572.16327195616 0.8547811073030727 0.6716446587868712 0.7741980777770919 0.7489352152437783 0.9002975743609777 0.9071556785239288 1.1469926077227413 1.3703918711603307 1.1989455618991025 1.0 16.205567300437956 -7.080968183315297 1.6655579423940314 1.222737529758111 0.7690874665689574 0.7658504239296782 0.10169281267270999 0.16150145573536534 0.892749761802893 0.049813478237751604 0.035226332141380545 8.299115651264082e-08 7.080968183315297 -0.45365006318915346 LS(ph)SATANALYSSNLR ddPTM_A459_Selumetinib_30min_R2 1 LSSATANALYSSNLR 15 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 LS(0.497)S(0.497)AT(0.006)ANALYSSNLR 115.26 0.0023948 3896500.0 13868.0 12600.0 18056.0 15288.0 12061.0 14007.0 14195.0 20256.0 18153.0 23876.0 True False 13097.272078002563 13566.379484614392 16894.296617886368 13205.748026728998 10545.789353291944 15936.337107113779 14855.09562685889 20314.941606438686 21784.107237198743 23186.63784270197 0.5648629252267788 0.5850947246706762 0.7286220940050553 0.5695413072096405 0.45482184285770644 0.6873069401103259 0.640674845902014 0.876148657009056 0.9395112557923236 1.0 14.501006018018936 -7.842656078157558 1.6287999100659192 0.9865550974522003 0.5932885886605076 0.8313787805527593 0.0700820591818677 0.15824823953330425 0.7806900607146066 0.05922287709871256 0.021852238890556052 1.4366266610279954e-08 7.842656078157558 -0.39326650879169267 LS(ph)SDLTR ddPTM_A459_Selumetinib_30min_R2 1 LSSDLTR 7 0 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;Q7Z6E9-4 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 LS(0.654)S(0.346)DLTR 98.582 0.021764 3377700.0 36538.0 22853.0 27060.0 32973.0 31640.0 24965.0 31877.0 30706.0 28819.0 24365.0 True False 34507.364233202905 24605.751616023215 25318.989060700336 28482.020518402354 27665.10033481113 28403.702140293823 33359.343663077176 30795.349376348055 34583.605270138854 23661.51914212739 1.4583748416966762 1.0399058263429375 1.0700491759898019 1.203727467679472 1.16920220416261 1.2004175205185101 1.4098563774666357 1.3014950219962618 1.4615969947832128 1.0 14.53025508164881 -7.0980920942249695 6.877777877907191 1.3179475968854986 1.1752892283420255 0.08456360475553826 0.1551975389533489 0.4747431164177536 28.673673857639912 0.05679788108479778 0.0440013202607074 7.978254866130323e-08 7.0980920942249695 -0.14265836854347302 LS(ph)SDSFAR ddPTM_A459_Selumetinib_30min_R1 2 LSSDSFAR 8 0 A0A087WSV0;Q9HB09-3;Q9HB09 A0A087WSV0 BCL2L12 Bcl-2-like protein 12 1 LS(0.659)S(0.331)DS(0.011)FAR;LS(0.96)S(0.04)DSFAR 137.05 0.0025561 18644900.0 5166.0 5174.0 4963.3 4097.5 4727.6 4864.4 4635.5 5437.0 2676.0 3941.2 True False 5286.357748713838 4568.225674672655 4289.311121455378 3381.9485446010754 4299.989414725573 4815.468552521817 4285.840502937539 5292.793098135014 4540.976552692942 4447.09141053896 1.1887225291087875 1.0272389867783298 0.9645205653498227 0.7604855021838204 0.9669217512676315 1.0828355228115745 0.9637401409786001 1.1901696208879051 1.0211115836142894 1.0 12.1186463444394 -6.752798096866251 24.605929919736088 1.0579675225701708 0.9708840393010193 0.08305502780658902 0.11253729887521961 369.23673003009355 1051394.3312097264 0.03965258956312763 0.039054858415309056 1.7668590410383316e-07 6.752798096866251 -0.0870834832691515 LS(ph)SDSFAR ddPTM_A459_Selumetinib_30min_R2 4 LSSDSFAR 8 0 A0A087WSV0;Q9HB09-3;Q9HB09 A0A087WSV0 BCL2L12 Bcl-2-like protein 12 1 LS(0.944)S(0.047)DS(0.008)FAR;LS(0.768)S(0.223)DS(0.009)FAR;LS(0.758)S(0.236)DS(0.005)FAR;LS(0.967)S(0.032)DS(0.001)FAR 136.99 0.0025596 36379300.0 185966.4 119757.8 152911.2 171885.0 153304.0 123679.3 180849.0 143028.4 124334.0 148490.6 True False 175631.13197048302 128942.83817798045 143073.05986912647 148473.96648183637 134044.580964851 140715.00092609815 189258.8368454949 143444.58896437375 149204.27418222168 144203.29055308763 1.2179412224010617 0.8941740350266894 0.9921622406837861 1.0296156621140107 0.9295528586811493 0.9758099165864368 1.3124446475499831 0.9947386666018236 1.0346800937062735 1.0 17.1377445600312 LS(ph)SGFDDIDLPSAVK ddPTM_A459_Selumetinib_30min_R1 1 LSSGFDDIDLPSAVK 15 0 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 LS(0.858)S(0.142)GFDDIDLPSAVK 230.96 6.21e-14 75383000.0 5260.9 5396.3 4223.3 4433.5 4633.6 5006.9 4912.7 4864.6 2503.6 4985.6 True False 5383.468734070583 4764.498687328193 3649.79905692634 3659.2724521022215 4214.491698128526 4956.535131901465 4542.13108376254 4735.575005552254 4248.4263442907495 5625.550323856452 0.9569674830284131 0.8469391282703899 0.6487896911078228 0.6504736854960175 0.7491696732772961 0.8810756008851485 0.8074109771093111 0.8417976434180934 0.7552019090957752 1.0 12.457778520665176 -6.750635361079369 24.889227469367125 0.8441041889500542 0.7612900697923316 0.14209518785563935 0.102778716735875 460.9436801095517 1061874.1337331368 0.03608773215791552 0.03574450523519868 1.7756797374534585e-07 6.750635361079369 -0.08281411915772263 LS(ph)SGFDDIDLPSAVK ddPTM_A459_Selumetinib_30min_R2 4 LSSGFDDIDLPSAVK 15 0 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 LS(0.5)S(0.5)GFDDIDLPSAVK;LS(0.5)S(0.5)GFDDIDLPSAVK;LS(0.993)S(0.007)GFDDIDLPSAVK;LS(0.947)S(0.053)GFDDIDLPSAVK 199.84 2.0812e-05 29865300.0 57843.38 41470.0 54745.36 64331.0 60862.3 43067.0 60913.0 57266.0 41156.0 44724.02 True False 54628.6765049965 44650.61565293323 51223.10313984114 55569.00682283511 53216.23375813456 48999.08832669874 63745.575196819635 57432.63457910332 49388.349994719916 43432.721335640825 1.257776966882531 1.0280409396381296 1.1793666517922639 1.2794272408907352 1.2252567216981036 1.1281606774772863 1.4676854969368478 1.3223356219213966 1.137123083148647 1.0 15.40649472917374 -5.5384216592750475 9.171105658800517 1.2417237625740731 1.1331376689899526 0.04463363333050596 0.12965321207675412 0.43311502337090085 224.85234334097782 0.034451146648817606 0.060943054391681704 2.8945319035437738e-06 5.5384216592750475 -0.10858609358412052 LS(ph)SPISK ddPTM_A459_Selumetinib_30min_R1 1 LSSPISK 7 0 Q99728-3;Q99728-2;Q99728;A0A494C142 Q99728-3 BARD1 BRCA1-associated RING domain protein 1 1 LS(0.499)S(0.499)PIS(0.001)K 85.67 0.035913 41585000.0 11233.0 15345.0 12501.0 12693.0 11697.0 11401.0 12493.0 10126.0 5992.9 10414.0 True False 11494.707044386863 13548.400266303037 10803.43286307773 10476.40582711932 10639.008415273074 11286.316291279752 11550.642951827995 9857.425586116447 10169.513595901923 11750.73834095015 0.9782114715574047 1.1529828912186917 0.9193833229550219 0.8915529835780694 0.9053906321951866 0.9604772026918569 0.982971675198924 0.8388771241517907 0.8654361369329604 1.0 13.520463788881118 -5.287908891261401 22.97820590724096 0.9168405573592291 1.0655971319322233 0.46930825121285147 0.06161431773422788 191.4307725015641 166181.03623647869 0.015882723603115698 0.03308773840211552 5.153367434825232e-06 5.287908891261401 0.14875657457299418 LS(ph)SPISK ddPTM_A459_Selumetinib_30min_R2 2 LSSPISK 7 0 Q99728-3;Q99728-2;Q99728;A0A494C142 Q99728-3 BARD1 BRCA1-associated RING domain protein 1 1 LS(0.493)S(0.493)PIS(0.015)K;LS(0.5)S(0.5)PISK 106.68 0.017016999999999997 56781000.0 457370.0 431040.0 501580.0 492730.0 517110.0 396650.0 407770.0 420710.0 358250.0 439180.0 True False 431951.2063971756 464099.38198795036 469308.8888790125 425619.32399333984 452146.01877794485 451284.93706979963 426732.1129809261 421934.19644771045 429910.0103413453 426499.73227332166 1.0127818934253408 1.0881586713178357 1.1003732320710031 0.9979357354451571 1.0601320107938257 1.0581130606210896 1.0005448554595002 0.9892953371828018 1.0079959676641441 1.0 18.7021853103577 -7.265518644941827 21.334677223646093 0.9985669504503641 1.0545038007262626 0.44873395183500586 0.028987682188832777 43.69521669878249 228518.91871451968 0.012025849247678175 0.008476605287441853 5.4260195607776054e-08 7.265518644941827 0.05593685027589845 LS(ph)SPVK ddPTM_A459_Selumetinib_30min_R2 1 LSSPVK 6 0 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 LS(0.767)S(0.233)PVK 89.75200000000002 0.047937 43198000.0 289210.0 208450.0 205510.0 212960.0 226460.0 156210.0 359630.0 473750.0 249960.0 398020.0 True False 273136.8659993596 224437.44472760824 192287.71034236948 183954.48062350944 198010.0702219134 177726.50956680556 376353.50759332615 475128.53406646603 299958.9844659394 386528.1284198455 0.7066416281680781 0.580649707552008 0.49747404187233496 0.47591486129490357 0.5122785527443828 0.4598022666380431 0.9736768941807317 1.2292211074232173 0.7760340384338731 1.0 18.560213880191625 -7.294531651232634 7.160656090367463 1.0160302855441903 0.5347177955107476 0.7712280612837135 0.1214477605229039 0.10207950817277296 17.90468622476891 0.04968303752705151 0.033868072189883046 5.075377485042492e-08 7.294531651232634 -0.4813124900334427 LS(ph)SPVLHR ddPTM_A459_Selumetinib_30min_R1 2 LSSPVLHR 8 0 Q16643-3;Q16643;Q16643-2;D6R9W4;D6RCR4 Q16643-3 DBN1 Drebrin 1 LS(0.625)S(0.375)PVLHR;LS(0.643)S(0.357)PVLHR 104.01 0.0098884 18880600.0 7383.9 9619.3 8737.9 8506.3 9432.400000000001 7347.6 9358.9 7755.099999999999 4125.0 8186.7 True False 7555.930503431691 8493.067884108757 7551.341173849039 7020.834388026871 8579.241085425476 7273.689815087021 8652.950638106384 7549.409555885014 6999.823721920178 9237.542690210934 0.8179589266135403 0.9194077006116465 0.8174621137990766 0.760032686557095 0.9287362855185435 0.7874052720530302 0.9367156318829201 0.8172530086258933 0.7577582000609235 1.0 13.173293411180772 -6.270611426376704 24.76872446811972 0.8612489469276402 0.8343895761512076 0.05606968605294149 0.07804743321294948 2906.313543003586 7848370.120614184 0.023616260302595123 0.027159274430914798 5.362762620770312e-07 6.270611426376704 -0.026859370776432634 LS(ph)SPVLHR ddPTM_A459_Selumetinib_30min_R2 2 LSSPVLHR 8 0 Q16643-3;Q16643;Q16643-2;D6R9W4;D6RCR4 Q16643-3 DBN1 Drebrin 1 LS(0.625)S(0.375)PVLHR;LS(0.5)S(0.5)PVLHR 85.86200000000002 0.02294 257088800.0 235445.0 205493.0 240699.0 239897.0 273962.0 164177.0 167536.0 181848.0 150850.0 198394.0 True False 222359.9094610122 221253.65233586187 225212.6883932556 207222.61475459283 239544.44430864532 186790.8914995804 175326.75596628617 182377.14757344284 181024.21510116427 192665.849730483 1.1541220707876758 1.1483802274527108 1.1689289446380966 1.0755544640862562 1.2433155364260973 0.9695070079148901 0.9100043220505752 0.9465982052790733 0.9395760346444167 1.0 17.555741349180643 -6.85224186693846 6.853291337178107 0.9445903804493712 1.15309435640618 0.8467984199120625 0.04355705197234255 0.07632429364966234 4.8486894410151145 0.014480040352869782 0.012790691490916252 1.4052646872664672e-07 6.85224186693846 0.2085039759568088 LS(ph)SSLGR ddPTM_A459_Selumetinib_30min_R1 2 LSSSLGR 7 0 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 LS(0.589)S(0.276)S(0.135)LGR;LS(0.481)S(0.26)S(0.26)LGR 113.41 0.014148 118350000.0 11594.8 13143.6 13747.4 14454.7 13425.8 10463.4 13071.0 12649.599999999999 6486.599999999999 9842.1 True False 11864.936280446613 11604.741201706129 11880.578589062854 11930.45799332401 12211.438760517507 10358.147696007072 12085.043946477525 12314.09151630838 11007.286437480583 11105.429405172406 1.0683905905448792 1.0449610526812376 1.069799118576128 1.0742905616749354 1.0995917685839298 0.9327102373171375 1.0882104154251666 1.1088352432885695 0.9911626138791074 1.0 13.438977557102126 LS(ph)TGSFPEDLLESDSSR ddPTM_A459_Selumetinib_30min_R1 4 LSTGSFPEDLLESDSSR 17 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 LS(0.492)T(0.492)GS(0.017)FPEDLLESDSSR;LS(0.819)T(0.136)GS(0.044)FPEDLLESDSSR;LS(0.465)T(0.07)GS(0.465)FPEDLLESDSSR;LS(0.384)T(0.384)GS(0.232)FPEDLLESDSSR 231.41 4.3732e-52 10499200.0 4745.12 4829.26 5675.790000000001 5387.8099999999995 5121.2699999999995 4560.76 5360.4 4367.91 3065.99 4496.97 True False 4855.672063603759 4263.847994137933 4905.0488928828045 4446.930125219551 4658.052032733654 4514.882895238754 4956.060712317198 4252.0588378287475 5202.76109895031 5074.199903697199 0.956933537455981 0.8402995694022969 0.9666644960733323 0.8763805544947879 0.9179874898778961 0.889772374152837 0.9767176710373744 0.8379762166505467 1.0253362495946283 1.0 12.308964641744588 -8.283223376045544 24.996179830451943 1.012668164190486 0.9085339279698418 0.4463772146845869 0.046691753162032626 769.0851210472961 882482.6583853065 0.0402822426331597 0.010437153305013358 5.2092670751991214e-09 8.283223376045544 -0.10413423622064422 LS(ph)TGSFPEDLLESDSSR ddPTM_A459_Selumetinib_30min_R2 2 LSTGSFPEDLLESDSSR 17 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 LS(0.947)T(0.013)GS(0.041)FPEDLLESDSSR;LS(0.5)T(0.5)GSFPEDLLESDSSR 191.51 3.2909999999999996e-15 1374000.0 12057.9 5910.2 10487.3 11068.7 9933.9 9531.0 12711.4 11343.3 12334.1 11156.9 True False 11387.770189598146 6363.4933357117425 9812.558535708884 9561.12396542748 8685.914671807217 10843.808736196293 13302.505287161259 11376.307125015597 14801.264643548338 10834.771307892514 1.0510392758638851 0.5873214260716606 0.9056544210177279 0.8824481563780442 0.8016703283326362 1.000834113434143 1.2277605967992276 1.049981287258791 1.3660892531037052 1.0 13.403381081993373 -6.994275847026158 3.4340749361723253 1.1637902358942829 0.8373748764112044 0.5206068086456876 0.1421897348621462 0.18058716148347484 4.51214518438995 0.05211460593056234 0.04270322283849589 1.0132675929908895e-07 6.994275847026158 -0.3264153594830784 LS(ph)TGTTVEDVQK ddPTM_A459_Selumetinib_30min_R2 1 LSTGTTVEDVQK 12 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 LS(0.871)T(0.126)GT(0.002)TVEDVQK 85.45700000000002 0.031232 9930100.0 72323.0 38314.0 60830.0 58602.0 51056.0 52298.0 65829.0 63876.0 67883.0 92528.0 True False 68303.5771919079 41252.560601072684 56916.26402669625 50620.30650591135 44641.888833568824 59501.57478602393 68890.17893768885 64061.868584758915 81461.49680949494 89856.47622338454 0.7601408386202925 0.45909390546896367 0.633413042875191 0.5633462231488859 0.4968132594315008 0.6621846002296164 0.7666690463848909 0.7129354641673257 0.9065734628518088 1.0 16.455334866352622 -8.032316758566955 0.8109770452228321 0.9984792690486715 0.5778755449178721 0.7229744923272656 0.08561751142473946 0.30007498623107537 0.39320048123355356 0.07766701879828167 0.031591666474281216 9.282890795858213e-09 8.032316758566955 -0.4206037241307994 LS(ph)TPGAR ddPTM_A459_Selumetinib_30min_R2 1 LSTPGAR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 LS(0.5)T(0.5)PGAR 93.195 0.026027 3429300.0 45360.0 47163.0 46740.0 58386.0 51582.0 43588.0 42935.0 47829.0 43917.0 49741.0 True False 42839.07279046701 50780.25044705306 43732.79928666418 50433.72607853218 45101.80801106915 49591.85134753164 44931.562574088486 47968.1744714828 52701.6271435056 48304.84808736131 0.8868483079170602 1.0512454227206116 0.905350104974383 1.0440717252090455 0.9336911261888388 1.0266433559182866 0.930166729700255 0.9930302313492505 1.091021486046132 1.0 15.559880371107232 -8.017052683055423 22.816609758469113 1.044349186286503 0.9720803208540534 0.2158083299844057 0.057896503754876906 336.5281609186598 450270.0816087904 0.03332875894937178 0.013318010499120675 9.614956349482991e-09 8.017052683055423 -0.0722688654324497 LS(ph)VASTPISQR ddPTM_A459_Selumetinib_30min_R2 2 LSVASTPISQR 11 0 Q9BXS6-4;Q9BXS6-6;Q9BXS6-3;Q9BXS6-5;Q9BXS6-2;Q9BXS6;Q9BXS6-7;H0YMD2 Q9BXS6-4 NUSAP1 Nucleolar and spindle-associated protein 1 1 LS(0.844)VAS(0.077)T(0.077)PIS(0.002)QR;LS(0.384)VAS(0.294)T(0.294)PIS(0.028)QR 113.38 0.0071316 11671600.0 97538.0 98004.0 111337.0 110197.0 104729.0 78373.0 95014.0 80206.0 70003.0 99661.0 True False 92117.22843555057 105520.59166747205 104173.69863455989 95187.9784995717 91572.00673086086 89168.16935074095 99432.33926666935 80439.3861811819 84005.556047244 96783.52797962485 0.9517862218759308 1.0902742839637602 1.0763577316223774 0.9835142455192474 0.9461528076362216 0.92131555040557 1.0273684101245217 0.8311268235449758 0.8679736914005562 1.0 16.562473909236786 -6.086256472172426 2.5812633152722815 0.9269993806104707 1.0438835134274114 0.35853212820557956 0.06362913821238286 0.3015601597328804 3.9434188149494136 0.020454970017455748 0.02908915085261066 8.198672295647242e-07 6.086256472172426 0.11688413281694066 LS(ph)VEGPR ddPTM_A459_Selumetinib_30min_R2 1 LSVEGPR 7 0 H0Y687;Q5TGP6;Q5TGP6-2 H0Y687 MROH9 Maestro heat-like repeat-containing protein family member 9 1 LS(1)VEGPR 80.455 0.04486 2580400.0 17027.0 15937.0 15675.0 17936.0 21973.0 15217.0 13411.0 15188.0 15546.0 14519.0 True False 16080.707504481512 17159.316654468224 14666.487565649575 15493.085858674205 19212.55529888765 17313.003623827415 14034.63807339236 15232.194565491245 18655.634391532603 14099.798745107644 1.140491988232187 1.216990182957198 1.0401912701582752 1.0988160993468084 1.362612023491047 1.2278901235973096 0.9953786098019382 1.0803129066488641 1.3231135230214364 1.0 13.783386949868035 -10.688939181906415 4.952124197196287 0.9999880464809988 1.1611641587580295 0.16073805141732878 0.11284882378051928 1.5423702116978846e-05 2.597520535089858e-06 0.11315858525439304 0.027442953317925924 2.046731238516094e-11 10.688939181906415 0.16117611227703066 LS(ph)VPTSDEEDEVPAPKPR ddPTM_A459_Selumetinib_30min_R2 1 LSVPTSDEEDEVPAPKPR 18 1 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 LS(0.853)VPT(0.127)S(0.02)DEEDEVPAPKPR 125.39 0.0039313 31897000.0 28212.0 23310.0 28908.0 27735.0 28210.0 24701.0 24038.0 22693.0 19093.0 29472.0 True False 26644.08998158412 25097.802046536624 27048.090752650587 23957.44515445635 24666.00759940019 28103.338536647218 25155.81463039337 22759.03287297162 22912.133502993194 28621.06678254787 0.930925817126801 0.8768996011651247 0.9450413207219646 0.8370563311450279 0.8618130060211684 0.9819109381968828 0.8789265201579597 0.795184646536281 0.8005338751721237 1.0 14.80478982566047 -7.527937745708002 24.99402884104016 0.846126662874902 0.9034411992248518 0.04969639394474634 0.06621071142062446 291.67326944826544 1440982.846244646 0.02997611544946936 0.017350424346993028 2.965256416127926e-08 7.527937745708002 0.05731453634994976 LSAEYEKVELPS(ph)EEQVSGSQGPSEEKPAPLATEVFDEK ddPTM_A459_Selumetinib_30min_R1 2 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 38 2 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 LS(0.133)AEY(0.16)EKVELPS(0.238)EEQVS(0.198)GS(0.198)QGPS(0.069)EEKPAPLAT(0.004)EVFDEK;LS(0.078)AEY(0.382)EKVELPS(0.496)EEQVS(0.018)GS(0.018)QGPS(0.006)EEKPAPLAT(0.001)EVFDEK 44.215 0.0057855 14790400.0 1871.06 2031.75 1161.8899999999999 862.11 1256.29 1370.56 1967.9299999999998 2019.81 1161.9499999999998 2303.2 True False 1914.652057551009 1793.8717654650495 1004.1117198049258 711.5586723089768 1142.6587913160138 1356.7734107689128 1819.4874557104663 1966.2380775324782 1971.7442845297317 2598.8381550678305 0.7367338569419442 0.6902591305914657 0.3863694696981691 0.27379876308242246 0.43968062770195476 0.5220692208643907 0.7001157236984529 0.7565835039393435 0.7587022226392811 1.0 11.34365107616694 -7.973992356995093 0.941074859380073 0.9538630831618061 0.49620334127191146 0.5677926084833638 0.13527711048921665 0.450812666081309 0.7499838862647742 0.1416449056306538 0.054230737629238156 1.0617142417920007e-08 7.973992356995093 -0.45765974188989467 LSANSQS(ph)PDFK ddPTM_A459_Selumetinib_30min_R1 1 LSANSQSPDFK 11 0 Q68D86-2;Q68D86 Q68D86-2 CCDC102B Coiled-coil domain-containing protein 102B 1 LSANS(0.019)QS(0.981)PDFK 73.499 0.038067 31368000.0 2884.1 3399.5 3970.9 3932.3 3557.9 2520.7 2736.8 2751.1 1613.5 1932.6 True False 2951.2939185183077 3001.484959615325 3431.673590592378 3245.597623413006 3236.0885731982635 2495.3440466124785 2530.36097258968 2678.1318911677836 2737.991654622595 2180.668035118136 1.3533898195368486 1.376406179793763 1.5736799619784723 1.488350162035176 1.4839895486535855 1.1443025744527389 1.1603604637844842 1.2281245233287872 1.2555747186317 1.0 11.090554448707477 -6.761073688062402 24.99999793223071 1.1720982086806548 1.4592157694677637 0.750306065896426 0.08559009167606793 5.266326662505645 360034.35432714684 0.029950231697501852 0.028199946444572202 1.7335098429252214e-07 6.761073688062402 0.2871175607871088 LSAS(ph)PAQEK ddPTM_A459_Selumetinib_30min_R1 1 LSASPAQEK 9 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 LS(0.157)AS(0.843)PAQEK 92.112 0.026325 5928100.0 3294.3 4115.3 4486.8 4014.8 3987.6 3068.2 3497.7 3369.1 1671.6 2998.5 True False 3371.0507804080553 3633.478762848934 3877.517204228232 3313.6905471298082 3626.922284067958 3037.336693702705 3233.865672985573 3279.7405236208688 2836.5831111664866 3383.3866828633595 0.9963539779482538 1.073917675816446 1.1460461270559503 0.9794004817461279 1.071979830871266 0.8977208277985558 0.9558072949110129 0.9693661502637425 0.8383857291670507 1.0 11.724252354956652 -6.75641090665893 24.999885855658327 0.9318133357999414 1.0556921575140763 0.5148573924589743 0.058846505087988873 101.8428735640998 506328.60976862104 0.019383691556685737 0.01881023587287953 1.7522218568915587e-07 6.75641090665893 0.12387882171413489 LSAS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 LSASPPK 7 0 H0YCV3;Q8TEY7-3;Q8TEY7-2;Q8TEY7 H0YCV3 USP33 Ubiquitin carboxyl-terminal hydrolase 33 1 LSAS(1)PPK 93.598 0.025499 30486000.0 107380.0 97972.0 98708.0 93574.0 72245.0 64631.0 93130.0 100700.0 68230.0 88396.0 True False 101412.24947619817 105486.13737036835 92357.23474514465 80829.05977584621 63168.93722150547 73533.3335881968 97460.72953359397 100993.02032821756 81877.90650548489 85843.77779960992 1.1813581843162895 1.2288151811842523 1.075875702496918 0.9415832090303639 0.735859241527841 0.856594798982984 1.1353266600300627 1.1764745554881264 0.9538012958448452 1.0 16.389425946939724 -5.4876770990147365 3.4651318058406106 0.9717720030774595 1.2025068779985049 0.38075340092198573 0.11886988353952938 0.283837216200209 6.966919146506587 0.037765294863826175 0.08112576437457326 3.253290919419182e-06 5.4876770990147365 0.23073487492104539 LSAS(ph)SEDISER ddPTM_A459_Selumetinib_30min_R2 1 LSASSEDISER 11 0 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 LS(0.01)AS(0.939)S(0.051)EDISER 128.57 0.0027519000000000003 6561700.0 20155.0 20702.0 16586.0 24160.0 26685.0 18908.0 14699.0 18303.0 16716.0 18591.0 True False 19034.865786857627 22289.77683257835 15518.874817471386 20869.36632167536 23332.591733073168 21512.405370265402 15382.532625515945 18356.25869977523 20059.667084064018 18054.22952478106 1.0543161512780457 1.2346013881115014 0.8595700412565558 1.1559267202751726 1.29236153229619 1.1915438064381358 0.8520182267762814 1.0167289982981331 1.1110785456964702 1.0 14.1400492332619 -7.23593010757888 24.991045803118467 0.996350479507166 1.1321553913684401 0.22363899182341418 0.12451422596040912 1252.4971968645143 1227053.9759672876 0.04963441379702396 0.03843109832392949 5.808578893459173e-08 7.23593010757888 0.13580491186127408 LSASTASELS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 LSASTASELSPK 12 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;H0YF21 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 LSASTAS(0.013)ELS(0.987)PK;LSASTAS(0.037)ELS(0.963)PK;LSASTAS(0.001)ELS(0.999)PK 143.94 0.00078402 156227000.0 9368.6 12156.2 12440.6 13778.099999999999 10215.2 10281.4 10086.8 9778.900000000001 6632.3 9201.1 True False 9586.870151877756 10732.946452735943 10751.23485132428 11372.013481969012 9291.236963640047 10177.978450764293 9325.94455507073 9519.531805656146 11254.52869597362 10382.150811303674 0.9233992383774614 1.0337883399892762 1.0355498630995381 1.095342736650253 0.8949240993035967 0.9803342906253021 0.8982671052049264 0.9169132657263712 1.0840267012611815 1.0 13.341817729157352 -6.26686328094511 24.956562340532688 0.9559455556413072 1.0238270518244794 0.16135706346249468 0.06553718159964836 740.1262998431115 3405474.9308337052 0.020061341802434043 0.023378967269264233 5.409245831292515e-07 6.26686328094511 0.06788149618317219 LSASTASELS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 LSASTASELSPK 12 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;H0YF21 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 LSASTAS(0.003)ELS(0.996)PK;LSASTAS(0.001)ELS(0.999)PK;LSASTAS(0.107)ELS(0.893)PK;LSASTAS(0.049)ELS(0.951)PK 164.92 0.00051468 311685000.0 299971.0 283967.0 282253.0 244950.0 231200.0 166384.0 253154.0 223661.0 151955.0 238621.0 True False 283299.81269905606 305746.35580218217 264093.14927383023 211587.3874376807 202154.58904577573 189301.88571642875 264926.1626151347 224311.81648092845 182350.2459774439 231731.39171818487 1.2225353267786223 1.3193998168966636 1.1396520226098734 0.913071750309074 0.8723660076733224 0.8169022086858398 1.1432467593226165 0.9679820019970381 0.7869035119730573 1.0 17.822093967963994 -5.600734078657426 3.34841566033945 0.9290655470504817 1.266998843367599 0.6763031049876469 0.09722995840559712 0.1396267363591283 3.1155338704279827 0.028299552049441037 0.054530544725620494 2.507644229956107e-06 5.600734078657426 0.3379332963171172 LSCFAQTVSPAEK ddPTM_A459_Selumetinib_30min_R2 1 LSCFAQTVSPAEK 13 0 Q16658 Q16658 FSCN1 Fascin 0 176.51 5.573600000000001e-09 0.0 8542.8 6950.3 8039.1 8243.0 10635.0 6545.3 7486.5 7232.7 6960.8 9677.7 False True 8068.025375537952 7483.365661263124 7521.873058310278 7120.289180031866 9298.936221893691 7446.855662682359 7834.6370842183205 7253.745959562054 8353.154501002198 9398.27965531567 0.8584576828350361 0.7962484556448084 0.800345737111143 0.7576162277746894 0.9894296150928229 0.7923637022729384 0.833624596368235 0.7718163563540411 0.88879612092386 1.0 13.19818098188977 -8.561405893895332 6.387503580427537 0.9999921334214914 0.825799031953091 0.4320189289458304 0.06173307859713611 0.31443596106601746 48.85757636571941 0.058723443906171326 0.015207793438289634 2.74532715659896e-09 8.561405893895332 -0.1741931014684004 LSCIGS(ph)PIVSPR ddPTM_A459_Selumetinib_30min_R2 1 LSCIGSPIVSPR 12 0 Q9UKT4-2;Q9UKT4 Q9UKT4-2 FBXO5 F-box only protein 5 1 LS(0.002)CIGS(0.997)PIVS(0.001)PR 98.0 0.017111 0.0 12379.0 9841.5 11853.0 12947.0 10351.0 9150.5 8637.7 10978.0 6703.3 10316.0 True False 11691.02473706329 10596.31140458989 11090.39088457062 11183.596265179249 9050.614840885912 10410.898315031392 9039.370165277847 11009.94416249427 8044.147305851059 10018.1502758131 1.1669843648970832 1.057711365158162 1.1070297988388376 1.1163334505153006 0.9034217486971506 1.039203648219024 0.9022993183783309 1.0989997014793906 0.802957340864821 1.0 13.290328537358347 -6.24811936025675 24.754915040964914 0.9640573975031664 1.1077798776862824 0.4674057088989719 0.08042262341455769 631.2451165423284 1173152.397132801 0.021927763043455072 0.028140606071344595 5.647817304798407e-07 6.24811936025675 0.14372248018311595 LSCS(ph)ELSLYQPLQNSSK ddPTM_A459_Selumetinib_30min_R1 2 LSCSELSLYQPLQNSSK 17 0 Q12923-3;Q12923;Q12923-4 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 LS(0.024)CS(0.97)ELS(0.006)LYQPLQNSSK;LS(0.096)CS(0.903)ELS(0.001)LYQPLQNSSK 221.78 4.636e-12 21473000.0 2083.66 2089.58 1997.31 2244.62 2000.53 1936.3400000000001 2260.99 2080.9700000000003 1159.41 1782.6 True False 2132.205223903423 1844.931002180612 1726.086272438506 1852.6392537358058 1819.5824147222577 1916.8621776560508 2090.441703966508 2025.7759156568002 1967.4340900439925 2011.4140739944046 1.0600528511114287 0.9172308308039334 0.8581456671478513 0.9210630857607093 0.9046284592753224 0.9529923263634195 1.039289587854561 1.0071401716076664 0.9781347935668593 1.0 10.973994393160076 -7.061157179184771 5.3674952739097055 1.006207099392878 0.9267127611903996 0.3258050055980122 0.050035265683566574 0.2531465331964324 14.889129208247367 0.01986395168142234 0.015539123747516556 8.686459933800603e-08 7.061157179184771 -0.07949433820247842 LSCS(ph)ELSLYQPLQNSSK ddPTM_A459_Selumetinib_30min_R2 2 LSCSELSLYQPLQNSSK 17 0 Q12923-3;Q12923;Q12923-4 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 LS(0.01)CS(0.987)ELS(0.002)LYQPLQNSSK;LS(0.001)CS(0.988)ELS(0.009)LY(0.002)QPLQNSSK 93.181 0.007476899999999998 10863800.0 129269.0 111238.0 134760.0 152197.0 141963.0 116474.0 96692.0 106032.0 81713.0 137433.0 True False 122084.74648480763 119769.59691345529 126089.68831559391 131467.50604553052 124128.33877467738 132517.23625429947 101188.36959156307 106340.53556545735 98057.88325198134 133464.952196183 0.9147326281236189 0.897386129786368 0.9447400702639295 0.9850339275009338 0.9300444553579764 0.9928991399892725 0.7581643564583465 0.7967674945040636 0.7347088628020033 1.0 17.02610141536745 -7.262026867831037 24.99988589364324 0.8054741341820892 0.943259711743382 0.39608927016929507 0.07243358126354424 47.38504334040636 2016341.178073102 0.027503335358133613 0.01983127517954556 5.469821225426321e-08 7.262026867831037 0.13778557756129273 LSCS(ph)LEDLR ddPTM_A459_Selumetinib_30min_R1 4 LSCSLEDLR 9 0 E9PI79;H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 E9PI79;H0YDJ2 PPFIBP2 Liprin-beta-2 1 LS(0.013)CS(0.987)LEDLR;LS(0.01)CS(0.99)LEDLR;LS(0.001)CS(0.999)LEDLR;LS(0.001)CS(0.999)LEDLR 144.55 0.0019369 80987000.0 17587.899999999998 21110.199999999997 14546.0 14219.2 17455.2 15109.800000000001 19657.1 17800.1 8425.5 17423.4 True False 17997.663849904016 18638.60797013427 12570.733095458649 11736.083647441514 15876.380241965862 14957.809130600715 18174.34912097799 17327.983525126558 14297.458125827503 19659.86310828797 0.9154521448481896 0.9480538021791632 0.6394110185924555 0.596956529290072 0.807552939433891 0.7608297701877172 0.9244392507146332 0.8813888189191732 0.7272409806251475 1.0 14.262965655771094 -7.246657846812691 24.193321842095816 0.8733829980580289 0.7725792155287142 0.15551724839906766 0.11882866032754998 1157.2791208044637 1894151.6603588548 0.04915074974847105 0.03788327102710036 5.666855689787713e-08 7.246657846812691 -0.10080378252931466 LSCS(ph)LEDLR ddPTM_A459_Selumetinib_30min_R2 4 LSCSLEDLR 9 0 E9PI79;H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 E9PI79;H0YDJ2 PPFIBP2 Liprin-beta-2 1 LS(0.001)CS(0.999)LEDLR;LS(0.001)CS(0.999)LEDLR;LS(0.007)CS(0.993)LEDLR;LS(0.024)CS(0.976)LEDLR 163.84 0.00096456 81549100.0 371966.0 290273.0 402439.0 406140.0 442218.0 365549.0 400053.0 471522.0 391974.0 342050.0 True False 351293.618817876 312536.00572519685 376546.5128824538 350823.03136942093 386662.62136092037 415900.05662656773 418656.25718998036 472894.0509553308 470379.75266863545 332174.12774736993 1.0575586401029013 0.9408800373606804 1.1335817013684781 1.056141951055966 1.1640359349569538 1.2520543350169473 1.2603517920829257 1.4236330028538022 1.4160637851554043 1.0 18.341580184028082 -6.532621081842392 1.197566845095565 1.3119371829733668 1.0273188425873936 0.4323338004457187 0.11868382137626383 0.38171038673906876 1.1495414770871362 0.05257105043223559 0.05899320537245734 2.933451539994132e-07 6.532621081842392 -0.2846183403859732 LSCS(ph)LEDLRSESVDK ddPTM_A459_Selumetinib_30min_R2 1 LSCSLEDLRSESVDK 15 1 E9PI79;H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 E9PI79;H0YDJ2 PPFIBP2 Liprin-beta-2 1 LS(0.474)CS(0.516)LEDLRSES(0.01)VDK 132.81 0.0028093000000000003 3931600.0 14011.0 17808.0 18308.0 18226.0 16566.0 13255.0 10526.0 12530.0 7669.1 16560.0 True False 13232.324710476916 19173.81633825502 17130.083212243226 15743.587358396318 14484.830978080963 15080.755933090111 11015.479856873311 12566.46022554684 9203.134292557752 16081.869771952786 0.8228100897542676 1.1922628780202331 1.065179823935557 0.9789649824085479 0.9006932143762847 0.93774891520334 0.6849626326463981 0.7814054213685454 0.5722676792600488 1.0 13.97314753195582 -6.825256579221961 1.3116033366247333 0.7415356548955707 1.0314983690704715 0.3839553291230189 0.1367659964216638 0.3929061054473524 1.412423911991136 0.06517577857941202 0.055501748396087 1.495351947885471e-07 6.825256579221961 0.2899627141749008 LSDDFDS(ph)PVKGPLCK ddPTM_A459_Selumetinib_30min_R1 1 LSDDFDSPVKGPLCK 15 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 LS(0.003)DDFDS(0.997)PVKGPLCK 88.427 0.009699700000000002 34453000.0 3574.8 3648.1 4265.7 5031.1 3451.8 3742.1 3363.1 3269.2 2179.8 3016.0 True False 3658.085884650065 3220.9787560443233 3686.4413698128656 4152.512830443553 3139.585299464788 3704.457871554948 3109.4186593526574 3182.4901961418054 3698.961393707056 3403.132978327794 1.0749171154773822 0.946474550526387 1.0832492862574772 1.2202029297379922 0.922557337447182 1.0885433790410437 0.9136929644402377 0.9351648073727621 1.086928256187222 1.0 11.732647810759532 LSDDFDS(ph)PVKGPLCK ddPTM_A459_Selumetinib_30min_R2 1 LSDDFDSPVKGPLCK 15 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 LS(0.004)DDFDS(0.996)PVKGPLCK 84.89200000000002 0.011703 8531800.0 43728.0 35804.0 43346.0 41430.0 36809.0 31539.0 28955.0 31724.0 23672.0 37365.0 True False 41297.77281705338 38550.05167199476 40557.16555155642 35787.162529263645 32184.72434336483 35883.210967463536 30301.46487324404 31816.311587809094 28407.06145094301 36286.17536407102 1.1381131354489518 1.0623894991745348 1.1177029583479978 0.9862478525278396 0.8869693215238311 0.9888948230954513 0.8350691294747812 0.8768163430999732 0.7828618245358102 1.0 15.147132381418489 -6.028285313866167 1.0945702922180622 0.8762143883130091 1.121702737370028 0.6745671988456836 0.06476176086014507 0.29572010952722566 0.7231205451465035 0.025341607292386447 0.049855717668312836 9.369462689803027e-07 6.028285313866167 0.24548834905701877 LSDEEMATILS(ph)FNR ddPTM_A459_Selumetinib_30min_R1 2 LSDEEMATILSFNR 14 0 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 1 LSDEEMATILS(1)FNR;LSDEEMATILS(1)FNR 176.43 6.8355e-05 8686500.0 1476.8600000000001 1971.46 2138.67 2199.73 2389.67 1814.8 2085.13 2074.3500000000004 1206.71 1635.38 True False 1511.2679645306857 1740.6405466931114 1848.2503608734062 1815.588449546143 2173.5247704305043 1796.5447597065609 1927.846965352207 2019.3314995615908 2047.6987353886773 1845.2969529501695 0.8189836124286366 0.9432847888846624 1.0016005055004913 0.9839004213622474 1.1778726274682134 0.9735802992761322 1.044735353987368 1.0943124879349004 1.1096852092639713 1.0 10.849637284186654 -4.179159396416481 0.7366987295558881 1.0655910357633316 0.3853497312873775 0.6256021858433456 0.05782832693871482 3.9289547691327016 0.8614621238269503 0.02238881886347591 2.717600793159764 6.619734990728657e-05 4.179159396416481 -0.6802413044759541 LSDEEMATILSFNR ddPTM_A459_Selumetinib_30min_R1 1 LSDEEMATILSFNR 14 0 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 0 202.0 0.00072111 25544000.0 671.85 879.18 859.13 1077.2 837.81 666.03 801.06 799.28 505.8 474.83 False True 687.5027978074709 776.2451968803065 742.4648648632882 889.0872415483283 762.030233427369 659.3303429068553 740.6353992628938 778.0804979726606 858.3056578296306 535.7790557358711 1.2831834138481082 1.448815866484674 1.385766869598033 1.6594288858999957 1.42228447579152 1.2306011887704185 1.3823522799816441 1.452241347702549 1.6019768758052366 1.0 9.0654943753287 -6.53503666548707 24.973210334605383 1.3604996849065567 1.452992589735781 0.07865017630673776 0.17030172855831893 715.9515722295918 1470604.4982802279 0.055603903929918874 0.055643566503593735 2.917180719443908e-07 6.53503666548707 0.09249290482922423 LSDPLLPS(ph)PEDETGSLVHLEDPER ddPTM_A459_Selumetinib_30min_R1 2 LSDPLLPSPEDETGSLVHLEDPER 24 0 Q8WYL5-4;Q8WYL5;Q8WYL5-2;Q8WYL5-5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 LSDPLLPS(1)PEDETGSLVHLEDPER;LSDPLLPS(1)PEDETGSLVHLEDPER 127.35 8.8586e-08 8020200.0 3205.7 3426.6000000000004 2201.3 2342.5 4053.7 3099.7 3706.8999999999996 3338.5 1396.13 3164.5 True False 3280.3865727936413 3025.4120790168786 1902.37555087537 1933.4263491709623 3687.043550738862 3068.519832302417 3427.28554855769 3249.95213502368 2369.1306406992508 3570.6943998402876 0.9186970951477585 0.8472895577824305 0.5327746756934619 0.5414706868382357 1.0325844605754495 0.8593622104539855 0.959837265466064 0.9101737004345838 0.6634929723488011 1.0 11.801988949893484 -6.267519493113829 24.983052610259694 0.9002862449601369 0.7071971630622448 0.2997844304274967 0.1452866721710243 685.9767604153811 2818659.4534442644 0.04730970533066501 0.05500738501027787 5.401078717200038e-07 6.267519493113829 -0.1930890818978921 LSDPLLPS(ph)PEDETGSLVHLEDPER ddPTM_A459_Selumetinib_30min_R2 1 LSDPLLPSPEDETGSLVHLEDPER 24 0 Q8WYL5-4;Q8WYL5;Q8WYL5-2;Q8WYL5-5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 LSDPLLPS(0.998)PEDET(0.001)GS(0.001)LVHLEDPER 91.883 2.5726e-05 1675700.0 8026.1 7669.3 9745.1 10382.0 12714.0 7923.6 9179.7 11362.0 8781.2 7390.6 True False 7580.041493023966 8257.510649313741 9118.110875662629 8967.953690051057 11116.753655397879 9015.003976720693 9606.574239230475 11395.06153891964 10537.685367227981 7177.21417491511 1.0561258600191656 1.1505175194819108 1.2704247990161832 1.2495034245173724 1.5488953491525652 1.2560589327581715 1.3384823143227573 1.5876719380544912 1.468213865493657 1.0 12.809208257410003 -5.295979725615846 1.0782262103514615 1.3876034047273604 1.022048942194902 0.2755403637304231 0.1594874981447989 1.0280796994839994 1.6966348189708413 0.05301395410451862 0.35353895612766406 5.058482762172464e-06 5.295979725615846 -0.3655544625324585 LSDPPTS(ph)PSSPSQMMPHVQTHF ddPTM_A459_Selumetinib_30min_R2 1 LSDPPTSPSSPSQMMPHVQTHF 22 0 Q13496;Q13496-2 Q13496 MTM1 Myotubularin 1 LS(0.025)DPPT(0.315)S(0.425)PS(0.178)S(0.056)PS(0.002)QMMPHVQTHF 57.142 0.014494 3738100.0 20828.0 17013.0 24820.0 24187.0 26363.0 18248.0 19757.0 18578.0 17037.0 28139.0 True False 19670.46314109009 18317.84239458292 23223.10822197273 20892.68887509776 23051.044251789703 20761.49636114889 20675.739647752805 18632.058904246547 20444.8760535534 27326.553956097774 0.7198296269881748 0.6703312252255427 0.8498366921523457 0.7645562959992498 0.843540107136194 0.7597553791269782 0.7566171600330573 0.6818298031350896 0.7481688355728892 1.0 14.738015918301565 -11.7461268119718 2.33200836188596 1.8085697249744779 0.7561724108815743 0.6371691628981181 0.05547055563975517 2881348.9891837337 466319.3781517713 12348693.528737947 0.014531826129126426 1.7942096494516526e-12 11.7461268119718 -1.0523973140929037 LSDPPTSPSS(ph)PSQMMPHVQTHF ddPTM_A459_Selumetinib_30min_R1 1 LSDPPTSPSSPSQMMPHVQTHF 22 0 Q13496;Q13496-2 Q13496 MTM1 Myotubularin 1 LSDPPTSPS(0.071)S(0.928)PS(0.001)QMMPHVQTHF 118.04 2.1947e-05 10499000.0 2674.2 3359.5 3643.1 3991.6 3546.2 2907.0 3753.2 2913.7 1278.0 2338.8 True False 2736.503656912612 2966.1681782108217 3148.3870301158695 3294.541991611872 3225.446836132462 2877.7582193448143 3470.093102281345 2836.4192109685464 2168.672658573088 2639.0077618411956 1.03694414866116 1.1239709943639467 1.193019238381962 1.248401781627698 1.2222195337091835 1.0904697822249094 1.314923416466314 1.0748051794245652 0.8217757787343672 1.0 11.365779878582552 -8.033044326003473 6.392711240282106 0.9198194331534832 1.1772140239126345 0.6037005876053263 0.08513456442525957 0.13092494051198159 16.796976647447913 0.05547122158007842 0.021706289708063122 9.267352318816098e-09 8.033044326003473 0.2573945907591513 LSDPPTSPSS(ph)PSQMMPHVQTHF ddPTM_A459_Selumetinib_30min_R2 2 LSDPPTSPSSPSQMMPHVQTHF 22 0 Q13496;Q13496-2 Q13496 MTM1 Myotubularin 1 LSDPPTS(0.001)PS(0.215)S(0.759)PS(0.026)QMMPHVQTHF;LSDPPT(0.005)S(0.023)PS(0.43)S(0.542)PSQMMPHVQTHF 96.234 0.00013401 19882100.0 135023.0 124511.0 157622.0 158570.0 189158.0 121557.0 96810.0 128869.0 106311.0 147518.0 True False 127518.9621998947 134060.59333403382 147480.77212585782 136972.4924514928 165394.28094602443 138300.3733654194 101311.85682537583 129243.98745458847 127576.1705775261 143258.77204220585 0.8901302194767242 0.9357932601470148 1.029471145281129 0.9561194089471812 1.1545141605520477 0.9653885161368991 0.7071947873148604 0.9021715432302572 0.8905295554253428 1.0 17.128263955438698 -7.020550057964585 24.969365552306982 0.8624601678021384 0.9969685552647847 0.2597876999376628 0.0938573189812731 949.9648798010224 1154253.1062128143 0.03559303546716344 0.027913180872271976 9.537838007874868e-08 7.020550057964585 0.13450838746264626 LSDS(ph)PSMKK ddPTM_A459_Selumetinib_30min_R1 1 LSDSPSMKK 9 1 F6VRR5;Q9BY77-2;Q9BY77 F6VRR5 POLDIP3 Polymerase delta-interacting protein 3 1 LS(0.001)DS(0.747)PS(0.252)MKK 102.53 0.028819 21601000.0 2249.3 2709.9 3477.0 4048.9 2957.3 2615.3 2625.1 2438.3 1422.9 2210.5 True False 2301.704313624089 2392.6236482016684 3004.8424977938766 3341.835622266086 2689.8127371537216 2588.992456502406 2427.0865935198635 2373.6283632853783 2414.5573754958095 2494.239207093365 0.9228081681493394 0.9592598983278299 1.2047130400518151 1.3398216228669013 1.0784100937488934 1.0379888380952285 0.9730769152443253 0.9516442354586594 0.9680536528449443 1.0 11.284384116444935 -6.961174934499395 2.598019496488709 0.9701000709382664 1.112135344452231 0.22825071827265186 0.11031621257068418 0.463227830337326 6.333031342054572 0.05062325126811749 0.041529279564009876 1.0935158076644446e-07 6.961174934499395 0.1420352735139646 LSDS(ph)PVFDAPPSPPDSLSDR ddPTM_A459_Selumetinib_30min_R2 1 LSDSPVFDAPPSPPDSLSDR 20 0 P47974 P47974 ZFP36L2 Zinc finger protein 36, C3H1 type-like 2 1 LS(0.067)DS(0.933)PVFDAPPSPPDSLSDR 82.367 0.014891 0.0 3502.7 2936.9 4213.4 3554.8 4932.0 1565.3 3825.0 4428.3 3510.2 1310.6 True False 3308.033956419063 3162.1507863780957 3942.314431203057 3070.6301076279615 4312.398067360576 1780.9058666213468 4002.8700790937114 4441.185619855469 4212.338083182668 1272.7595726522532 2.599103575803859 2.4844839939318746 3.0974541585947963 2.412576714099425 3.388226779056268 1.399247670092308 3.1450323887584593 3.489414430881599 3.309610215230787 1.0 10.313744201071911 -5.131844500995684 18.127466874230404 2.738064091755803 2.5416865380664535 0.0 0.8083679307407137 17.238185435798233 2391.113495590019 0.1978551658909184 0.5234982782926988 7.381684838145935e-06 5.131844500995684 -0.1963775536893495 LSDT(ph)PAPK ddPTM_A459_Selumetinib_30min_R1 1 LSDTPAPK 8 0 I3NI13;I3L270;J3KNE2;H3BNM4;Q8NBZ0-2;Q8NBZ0 I3NI13 INO80E INO80 complex subunit E 1 LSDT(1)PAPK 131.52 0.0082976 11722000.0 5879.9 6725.1 6320.1 6098.3 4447.3 5628.7 5499.5 4308.5 3337.0 4279.7 True False 6016.890229706255 5937.722165585831 5461.865133824294 5033.346384268631 4045.04250023459 5572.080388450697 5084.668287327148 4194.224584019626 5662.645275163058 4829.041182808177 1.2459803099478481 1.229586151951791 1.1310454657684486 1.0423076121586619 0.8376492034558137 1.1538688898093905 1.0529353747135202 0.8685418958428941 1.1726231069063122 1.0 12.23752105175099 -5.539971864495269 2.326533909823319 1.011606898246161 1.2396955483576277 0.4423489928811547 0.0996693990781689 0.27186253424540807 2.9180900752023224 0.028208367324968165 0.06598770358786227 2.8842183494114694e-06 5.539971864495269 0.22808865011146673 LSDVDANTAIKHEEQS(ph)NEDIPIAEQSSK ddPTM_A459_Selumetinib_30min_R1 1 LSDVDANTAIKHEEQSNEDIPIAEQSSK 28 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LS(0.002)DVDANT(0.004)AIKHEEQS(0.993)NEDIPIAEQS(0.001)SK 54.56 0.0038354 9641200.0 1313.3 1752.2 2412.8 2275.9 1741.9 1763.5 1518.5 1729.3 1172.4 1373.7 True False 1343.8973347630447 1547.0516094243208 2085.15501256171 1878.4567889341272 1584.345452557424 1745.760791129888 1403.9583224486357 1683.4333464419503 1989.47717129193 1550.0277759711178 0.8670150016641289 0.9980799269581266 1.3452371918014994 1.211885888791408 1.0221400397581946 1.1262771017352513 0.9057633316080629 1.0860665676698933 1.2835106584109373 1.0 10.59807835299821 -5.005268745171022 18.58997582638983 1.1212697950987685 0.8997759458896641 0.29241881724414254 0.1257014304827295 10.529999532172537 37204.75969693529 0.03282620155835283 0.11064628747448722 9.879415587074555e-06 5.005268745171022 -0.2214938492091043 LSEAVWQPEEHYSSS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 LSEAVWQPEEHYSSSPEK 18 0 F5H269;Q9Y485 F5H269 DMXL1 DmX-like protein 1 1 LSEAVWQPEEHYS(0.001)S(0.092)S(0.906)PEK;LSEAVWQPEEHYS(0.002)S(0.202)S(0.795)PEK 175.34 2.3537e-09 33950000.0 8143.6 9439.5 8223.8 9253.6 13260.1 8657.0 11756.3 7535.4 2107.69 4482.299999999999 True False 8333.330035312816 8334.318951695504 7107.053130099879 7637.6324715852315 12060.726296260798 8569.918439927096 10869.512825948572 7335.53671357119 3576.595990413075 5057.646866299297 1.6476694114095696 1.6478649403598562 1.4052094418565333 1.5101158055294839 2.3846517194834695 1.6944477672079437 2.1491245065715403 1.4503853091148367 0.7071660171146126 1.0 12.30425059370274 -8.08458664560812 4.339130790879818 0.8747344973981912 1.7704417470513885 0.6213185522253263 0.28467071811615685 0.15647635621737163 5.1706978798524 0.21590256920409095 0.07732369606006262 8.23025619616321e-09 8.08458664560812 0.8957072496531973 LSEAVWQPEEHYSSS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 LSEAVWQPEEHYSSSPEK 18 0 F5H269;Q9Y485 F5H269 DMXL1 DmX-like protein 1 1 LSEAVWQPEEHY(0.002)S(0.082)S(0.249)S(0.667)PEK 71.946 0.013728 10519000.0 27741.0 26727.0 32015.0 58607.0 63586.0 38718.0 29766.0 43078.0 35543.0 49507.0 True False 26199.26627602172 28776.87495914992 29955.189755296407 50624.62549728588 55597.7582139476 44051.05305299006 31150.177980210046 43203.34984805318 42652.5931543962 48077.60427536633 0.5449370173680954 0.5985505183313474 0.6230591188306078 1.052977290784528 1.156416985661542 0.9162489212375466 0.6479145217344068 0.8986169444010631 0.8871613674862381 1.0 15.55307738736724 -5.684121896517467 6.732342240053223 0.9285856868710962 0.5839815139401239 0.6193530439554198 0.12512761546012777 0.1641999618392833 11.57219003579888 0.03857778522752206 0.06702694381127078 2.0695603890472422e-06 5.684121896517467 -0.34460417293097234 LSEEAECPNPST(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 LSEEAECPNPSTPSK 15 0 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 LSEEAECPNPS(0.221)T(0.757)PS(0.022)K;LSEEAECPNPS(0.031)T(0.969)PSK 229.02 1.992e-13 51246000.0 8831.3 11047.2 11404.8 11862.3 9735.8 10574.1 13707.0 16232.6 11344.7 7763.700000000001 True False 9037.052107281559 9753.788688296054 9856.090802082137 9790.771987949065 8855.1986089951 10467.734154514632 12673.069954430988 15802.05871708413 19251.127315895217 8760.246519842016 1.0315979221375309 1.1134148640912853 1.1250928589461526 1.117636583145566 1.0108389745583093 1.194913194600762 1.446656772241101 1.803837218655019 2.1975554309220966 1.0 13.09675575356951 -7.421071074099844 2.4111518622291186 1.743927462230254 1.0908172261597595 0.4522662571366898 0.2804691785932721 0.2370567130588824 2.694727741559552 0.13821677213249894 0.08074121691266618 3.7925291357663884e-08 7.421071074099844 -0.6531102360704946 LSEEAECPNPST(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 LSEEAECPNPSTPSK 15 0 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 LSEEAECPNPS(0.071)T(0.927)PS(0.001)K;LSEEAECPNPS(0.305)T(0.695)PSK 238.07 1.3423e-19 69127000.0 323552.0 295366.0 333128.0 326184.0 345543.0 283036.0 344720.0 363590.0 352861.0 584290.0 True False 305570.2751212785 318019.62244862004 311694.9071623427 281757.17650121474 302132.7991463855 322021.63985500525 360750.163049721 364647.98670443567 423443.0597601054 567420.029532264 0.5385257114965898 0.5604659791632138 0.5493195356873095 0.4965583903223737 0.5324676314218936 0.5675189861035648 0.6357726979555071 0.6426420776951115 0.7462603322430444 1.0 19.11405755207913 -8.654937069631773 0.6537887429406661 1.0055168308963731 0.5320971480309705 0.9779376916561499 0.02108196000403565 0.13439443116135916 0.12668078400394597 0.024102149812998876 0.009534552004709521 2.2134154158582813e-09 8.654937069631773 -0.4734196828654026 LSEGPAAMAGPGS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 LSEGPAAMAGPGSPPR 16 0 Q8N2Y8 Q8N2Y8 RUSC2 Iporin 1 LSEGPAAMAGPGS(1)PPR 81.65100000000002 0.021257 13076000.0 559.44 617.83 936.37 703.04 630.42 580.24 546.81 642.28 529.93 805.95 True False 572.4738635192548 545.4941763786255 809.2160971122378 580.267261695263 573.3986223096908 574.4033124157678 505.5636814607435 625.2446479805326 899.2525054441593 909.4015331178001 0.6295061561602832 0.5998386372941868 0.889833662736321 0.6380759659661774 0.6305230433732018 0.6316278250009966 0.555930095837275 0.6875341916754181 0.9888398828195881 1.0 9.82877362603178 -8.249781377545752 4.744531831442245 1.0023318227701068 0.6561986003142494 0.7216009017620884 0.08382250491797567 0.0981855944307133 6.216145181577207 0.07162653246219146 0.02241063495064305 5.6262447727923816e-09 8.249781377545752 -0.3461332224558574 LSEGPAAMAGPGS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 LSEGPAAMAGPGSPPR 16 0 Q8N2Y8 Q8N2Y8 RUSC2 Iporin 1 LSEGPAAMAGPGS(1)PPR 115.04 0.0020318 21541000.0 39925.0 38202.0 35279.0 39576.0 36836.0 27631.0 30502.0 23784.0 21905.0 35603.0 True False 37706.12833243818 41131.970561209455 33009.187548870934 34185.68052759205 32208.33236198177 31436.919440755424 31920.403438566384 23853.20750234683 26286.612076837893 34575.04888229679 1.0905589305397794 1.1896431643881191 0.9547112329831697 0.9887384583018158 0.9315484259075963 0.9092371654419219 0.9232207753988269 0.6898965662651663 0.7602769316776653 1.0 15.077443670612777 -5.842372128972368 0.6296036442250617 0.8194856888647855 1.1806558374682277 0.5589322662615683 0.09086441034991638 0.8642021972189602 0.5934072910327268 0.05576960126740263 0.19157837963537655 1.4375662593221778e-06 5.842372128972368 0.3611701486034422 LSEGPAAMAGPGS(ph)PPRR ddPTM_A459_Selumetinib_30min_R1 2 LSEGPAAMAGPGSPPRR 17 1 Q8N2Y8 Q8N2Y8 RUSC2 Iporin 1 LSEGPAAMAGPGS(1)PPRR;LSEGPAAMAGPGS(1)PPRR 93.029 0.0038812 23707000.0 2800.5 3035.8999999999996 3114.6 3657.6 3147.8999999999996 2897.4 3040.8 2503.3 1444.19 2306.33 True False 2865.746201175592 2680.4554166483804 2691.6544272731676 3018.868821655372 2863.1730008068844 2868.2547866287127 2811.4300078378756 2436.9043521356216 2450.684950535733 2602.3699210566115 1.1012063188972168 1.0300055326339097 1.034308921838562 1.1600460016190373 1.1002175277388626 1.102170280797031 1.0803345001376214 0.9364173526668308 0.9417127560176797 1.0 11.34561033716405 -7.754747729522825 23.959533105011364 0.9542987756537642 1.0866006302386264 0.7003361555311148 0.03818223621669209 50.4821977421597 180755.3349809106 0.019604047066460094 0.010968439316774735 1.7589450431344114e-08 7.754747729522825 0.1323018545848622 LSEGPAAMAGPGS(ph)PPRR ddPTM_A459_Selumetinib_30min_R2 2 LSEGPAAMAGPGSPPRR 17 1 Q8N2Y8 Q8N2Y8 RUSC2 Iporin 1 LSEGPAAMAGPGS(1)PPRR;LSEGPAAMAGPGS(1)PPRR 112.44 0.00098676 25756000.0 57430.0 53828.0 62885.0 53576.0 64952.0 43600.0 49772.0 48856.0 42221.0 57072.0 True False 54238.27051050528 57956.434515700246 58839.047564011096 46278.856376244956 56792.14908175263 49605.50423860646 52086.496621346974 48998.162871453824 50666.379753306224 55424.18306913585 0.9786029763009539 1.0456885660074715 1.061613258072123 0.8349939288869074 1.024681753286474 0.8950155237602474 0.9397792396213498 0.8840574665815779 0.9141565458909018 1.0 15.758227980035945 -5.738892716500587 24.999962862965255 0.9258994453350899 1.0303403245616056 0.41328660538191353 0.05517074530171798 215.17850742637543 238590.16132815578 0.01411793426212304 0.024430883268143393 1.8243463138108217e-06 5.738892716500587 0.10444087922651568 LSEGS(ph)QPAEEEEDQETPSR ddPTM_A459_Selumetinib_30min_R1 2 LSEGSQPAEEEEDQETPSR 19 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 LSEGS(0.996)QPAEEEEDQET(0.003)PSR;LS(0.001)EGS(0.999)QPAEEEEDQETPSR 285.34 2.788699999999999e-72 19865300.0 2120.1400000000003 2797.5299999999997 2946.71 3388.7999999999997 3117.38 2575.79 2932.16 2456.89 1422.13 2160.36 True False 2169.5351369256987 2469.993887063585 2546.56296711941 2797.0096956544503 2835.4135294181424 2549.8798912301972 2710.9848105044393 2391.7252960965484 2413.250741734385 2437.663249688406 0.8900060897267165 1.0132629629540963 1.044673815156759 1.147414310000357 1.1631686738439277 1.0460345134038245 1.1121244129397163 0.9811549221994755 0.9899852828494086 1.0 11.251283123679976 -4.769103344212748 2.014966821352375 1.067888453802443 0.8349614565899245 0.41869569926924033 0.06038691016615763 0.7921776498627268 3.4446613518043114 0.01758428193613364 0.34927688199013823 1.7017535129125013e-05 4.769103344212748 -0.23292699721251842 LSEGS(ph)QPAEEEEDQETPSR ddPTM_A459_Selumetinib_30min_R2 2 LSEGSQPAEEEEDQETPSR 19 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 LSEGS(1)QPAEEEEDQETPSR;LSEGS(1)QPAEEEEDQETPSR 270.73 1.0315e-58 26947000.0 24309.7 25723.6 26641.0 26191.1 30750.0 24069.6 20541.8 27266.2 18008.9 27568.7 True False 22958.664193439497 27696.51740558941 24926.947064527612 22623.826997832406 26886.910091512094 27384.968917925748 21497.034402804504 27345.540127837612 21611.18321070833 26772.71999891514 0.8575394728055202 1.034505175668057 0.9310576984907651 0.8450328169401221 1.0042651659077442 1.02286838688917 0.8029454759798625 1.021395664278627 0.8072090998443205 1.0 14.708476097893161 -10.404441409000862 4.719548117050798 1.0000002688352234 0.9306625667093051 0.058179821967323075 0.08784477737367377 115264096.76189063 18.45150647299197 457.3575604573783 0.020018933691838225 3.940565865328565e-11 10.404441409000862 -0.06933770212591828 LSEGSQPAEEEEDQET(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 LSEGSQPAEEEEDQETPSR 19 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 LSEGS(0.001)QPAEEEEDQET(0.952)PS(0.047)R;LSEGSQPAEEEEDQET(1)PSR 220.89 6.2115e-19 15744100.0 26443.0 29315.0 28361.0 28403.0 28638.0 26656.2 26790.0 23170.4 24567.2 30206.0 True False 24973.40391971603 31563.366237418304 26536.284137122017 24534.462402092082 25040.238413031642 30327.84958910876 28035.7880833779 23237.822027933802 29481.326464920876 29333.87429538683 0.8513503422097726 1.0760040054573388 0.9046293670555213 0.8363867027939939 0.853628748827412 1.033884896475412 0.9557478770469446 0.7921838688586826 1.0050266858052648 1.0 14.840280008353531 LSEPGTDLVEPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 LSEPGTDLVEPSPK 14 0 Q8NEN9 Q8NEN9 PDZD8 PDZ domain-containing protein 8 1 LSEPGT(0.002)DLVEPS(0.998)PK;LS(0.001)EPGT(0.013)DLVEPS(0.986)PK 132.15 0.00083113 6604700.0 84774.0 30749.0 66416.0 61225.0 54641.0 52432.0 127043.0 82555.0 69912.0 45200.0 True False 80062.60045721018 33107.349426381574 62142.866868273275 52886.04938098397 47776.50908326218 59654.032069693036 132950.75123092873 82795.22138228398 83896.35350449165 43894.95855629627 1.8239589030373067 0.754240361883943 1.4157176339185662 1.2048319697843302 1.0884281624730945 1.3590178469626621 3.028838746035411 1.886212542520054 1.9112981596028322 1.0 15.421767631759046 -7.0298753975209 24.95429846204752 2.0537942272842296 1.2341882071385668 0.2834740127988238 0.523719672856267 722.9490623726625 603862.2160275768 0.1884459378930896 0.14620187616824934 9.335220971600663e-08 7.0298753975209 -0.8196060201456628 LSEPSLPIEDSQDLYNAS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 1 LSEPSLPIEDSQDLYNASPEPK 22 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 LSEPSLPIEDSQDLY(0.321)NAS(0.679)PEPK 104.89 4.450100000000001e-05 4355500.0 2222.7 2411.9 2722.1 3178.1 2071.4 2186.8 2139.2 2022.2 1331.0 2175.5 True False 2274.4845853786774 2129.5136267381113 2352.453771424996 2623.104495325607 1884.0422357353739 2164.802777455537 1977.8384217201983 1968.5646869686643 2258.6097876062418 2454.7466161644948 0.9265659316530706 0.8675085292776347 0.9583285525007343 1.0685846262308607 0.7675098616406943 0.8818844125093487 0.8057199910964911 0.8019421124794206 0.920098951449126 1.0 11.261358399031398 -6.274764917781182 24.955923154003784 0.8510506318083295 0.9492000089227257 0.2426437258293137 0.07802032488873743 1040.027782009093 1947748.8206446904 0.023875833345953168 0.027216539745421053 5.311718880777517e-07 6.274764917781182 0.0981493771143962 LSES(ph)QLSFR ddPTM_A459_Selumetinib_30min_R1 1 LSESQLSFR 9 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 LSES(0.999)QLSFR 122.55 0.0059098 6221700.0 1748.6 2280.4 2051.7 2527.3 1720.3 1874.8 2105.1 1755.4 888.79 1662.4 True False 1789.3389778166902 2013.4097078708025 1773.0904091813904 2085.9544982965926 1564.6991687436328 1855.941214182201 1946.3106121742658 1708.8410896572013 1508.2117153467718 1875.7852331472577 0.9539146306288354 1.073368993577497 0.9452523550398345 1.1120433519975554 0.8341568859236226 0.9894209536281712 1.0375977898646094 0.9110003957063082 0.8040428555971952 1.0 10.873278941507719 -6.899231301196614 0.6971892355820137 0.9151935440799833 1.0126242443589157 0.11399992667092496 0.08774673643719046 1.5371237574471495 1.602830094274989 0.06799421082980533 0.060672014616001795 1.261155675925466e-07 6.899231301196614 0.09743070027893241 LSES(ph)QLSFR ddPTM_A459_Selumetinib_30min_R2 1 LSESQLSFR 9 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 LS(0.015)ES(0.98)QLS(0.005)FR 119.03 0.007026999999999999 3493000.0 9239.8 9509.0 9194.0 7949.1 9317.2 7678.9 7053.6 7771.8 4956.6 7463.1 True False 8726.288905850026 10238.309723745895 8602.468049670322 6866.418867037645 8146.6900391751715 8736.598772886131 7381.606376443244 7794.414651309246 5948.058498975334 7247.620911537491 1.2040211556813964 1.4126442109365192 1.1869368106679048 0.9474031479912242 1.1240502419499414 1.2054436731063478 1.0184868202326174 1.0754445833254487 0.8206911718446279 1.0 12.823291781526951 -4.85396143571114 0.316239940441549 0.9522597892632036 1.5844406735575005 0.46302037588618794 0.11501887504827898 6.588195342786264 0.5552053251791227 0.13008626751706545 1.6100375504419853 1.3997116080252227e-05 4.85396143571114 0.6321808842942969 LSESSAS(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 2 LSESSASPQPK 11 0 Q8N5Y2;Q8N5Y2-3;Q8N5Y2-2;A0A3B3IT59;Q8N5Y2-6;Q8N5Y2-4;A0A3B3ITL5;A0A3B3ITF3;A0A3F2YNX2;A0A3B3IRN2;A0A3B3IU80;A0A3B3IUB0;A0A3B3IS72;A0A3B3ISB4;A0A3B3IRI6;A0A3B3ITV8;A0A3B3IRT2;A0A3B3ITF8;A0A3B3IT49;Q8N5Y2-5;A0A3B3ITX5 Q8N5Y2 MSL3 Male-specific lethal 3 homolog 1 LSES(0.012)S(0.129)AS(0.859)PQPK;LS(0.002)ES(0.224)S(0.044)AS(0.73)PQPK 163.71 0.00064187 43222000.0 11196.5 12942.8 13280.8 14190.0 12429.599999999999 10820.9 11823.9 11027.2 6525.1 9805.1 True False 11457.356665403504 11427.450959055526 11477.340306212522 11711.982879289624 11305.344874624108 10712.051570591093 10932.013703523491 10734.722834606298 11072.618125551839 11063.680094761898 1.0355827868548 1.0328797345167144 1.0373890249815223 1.0585973906489456 1.0218430737143807 0.968217761074158 0.988099222852553 0.9702669222773944 1.0008078714056612 1.0 13.43354372636624 -6.595509081642323 4.939145971202931 0.9840710864934277 1.0403300976050833 0.8292147579669885 0.011977442221619335 0.07625193421403412 3.474717809677962 0.0038908233918077007 0.003907372518882243 2.5379959127310953e-07 6.595509081642323 0.056259011111655655 LSESSAS(ph)PQPK ddPTM_A459_Selumetinib_30min_R2 3 LSESSASPQPK 11 0 Q8N5Y2;Q8N5Y2-3;Q8N5Y2-2;A0A3B3IT59;Q8N5Y2-6;Q8N5Y2-4;A0A3B3ITL5;A0A3B3ITF3;A0A3F2YNX2;A0A3B3IRN2;A0A3B3IU80;A0A3B3IUB0;A0A3B3IS72;A0A3B3ISB4;A0A3B3IRI6;A0A3B3ITV8;A0A3B3IRT2;A0A3B3ITF8;A0A3B3IT49;Q8N5Y2-5;A0A3B3ITX5 Q8N5Y2 MSL3 Male-specific lethal 3 homolog 1 LSES(0.006)S(0.036)AS(0.958)PQPK;LS(0.001)ES(0.008)S(0.008)AS(0.982)PQPK;LSES(0.075)S(0.045)AS(0.88)PQPK 153.49 0.00055963 70455100.0 305174.0 308059.0 329236.0 339416.0 340692.0 274437.0 294449.0 284490.0 233756.0 291294.0 True False 288213.6507883152 331686.1347341918 308053.3142050537 293186.9552747422 297891.22513487615 312238.20565895556 308141.46193962474 285317.8188001449 280513.7316883499 282883.5853472949 1.0188419042924552 1.1725181379010812 1.0889755721487269 1.0364226503803602 1.0530523528580014 1.1037692599788782 1.0892871764239018 1.0086050714107766 0.9916225126458449 1.0 18.10984893952336 -7.803832806614774 5.46088450102389 0.9981395826020266 1.082515372487547 0.4621857585531598 0.039731686681592285 0.17421776945877787 12.197781959417007 0.02233277246154121 0.010760572243184724 1.5709674742738715e-08 7.803832806614774 0.0843757898855203 LSFASETPLEKEPHS(ph)PADQPEQQAESTLTSAETR ddPTM_A459_Selumetinib_30min_R1 1 LSFASETPLEKEPHSPADQPEQQAESTLTSAETR 34 1 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2 H3BSS6 ZNF106 Zinc finger protein 106 1 LSFAS(0.008)ET(0.002)PLEKEPHS(0.991)PADQPEQQAESTLTSAETR 117.01 4.532e-19 10186000.0 697.15 727.59 1120.8 1335.6 1269.2 910.36 1142.8 850.43 622.86 532.03 True False 713.3922385822403 642.4034245525855 968.601516113712 1102.3625323170695 1154.4010840954597 901.2026049407451 1056.5976759264413 827.8738338140445 1056.9479281055035 600.3212329110536 1.1883508353067695 1.0700994556488843 1.6134720263296511 1.8362877604237609 1.922972270192051 1.5012006164943887 1.76005381452665 1.3790513951997865 1.7606372557908607 1.0 9.22959088568181 -5.267452996372317 22.703741254494535 1.6328783262138131 1.1292250880969474 0.3437043880071756 0.2544987755124719 118.95686208451792 449116.9727186124 0.06300219149918491 0.13746163869342193 5.401905763472904e-06 5.267452996372317 -0.5036532381168657 LSGEHS(ph)ESSTPRPR ddPTM_A459_Selumetinib_30min_R1 3 LSGEHSESSTPRPR 14 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 LSGEHS(1)ESSTPRPR;LSGEHS(0.561)ES(0.252)S(0.177)T(0.009)PRPR;LSGEHS(0.768)ES(0.155)S(0.07)T(0.007)PRPR 160.63 0.00015908 40416700.0 2537.9 3398.1800000000003 3228.55 3567.0 4463.969999999999 3127.78 3603.7 3162.59 810.98 1924.4299999999998 True False 2597.028132106243 3000.319505828976 2790.1306431557155 2944.0904108827417 4060.2047016779165 3096.3173729970176 3331.870007644483 3078.7078396598877 1376.1738283643213 2171.449336035595 1.1959883608648338 1.381712875376888 1.2849162984615814 1.3558181450633124 1.8698132322491177 1.425921996711169 1.5343991463910747 1.4178124207496687 0.6337582026559254 1.0 11.08444257707955 -8.24904963116646 24.139224904877196 0.8168791405175314 1.4417243500796575 0.6306714794151533 0.1885982376387915 264.6585927613817 515644.1059981082 0.13306870556858277 0.04943119094262942 5.635732470040317e-09 8.24904963116646 0.6248452095621261 LSGEHS(ph)ESSTPRPR ddPTM_A459_Selumetinib_30min_R2 2 LSGEHSESSTPRPR 14 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 LSGEHS(0.998)ES(0.002)STPRPR;LSGEHS(1)ESSTPRPR 140.03 0.00031115 29806000.0 34435.0 27262.0 40600.0 55896.0 56640.0 29743.0 26191.0 30149.0 34710.0 39928.0 True False 32521.240554226868 29352.907738853777 37987.840201937695 48282.86837402174 49524.37683197547 33839.82826992828 27408.93339648192 30236.728598564354 41652.96987843157 38775.17489459728 0.8387129301835387 0.7570025878321351 0.9796948770753504 1.2452005311457464 1.2772186577261815 0.8727189074431057 0.7068680791508417 0.7797960597407227 1.0742174597963003 1.0 15.242845668070625 -6.957120301207517 24.99997478540466 0.8601436854307337 1.021266278413208 0.11421856815625997 0.17773122873160316 295.262382899779 172144.72336514958 0.07005939467979382 0.06178656306824474 1.1037728283198526e-07 6.957120301207517 0.16112259298247433 LSGEHSESS(ph)TPRPR ddPTM_A459_Selumetinib_30min_R2 1 LSGEHSESSTPRPR 14 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 LSGEHS(0.001)ES(0.251)S(0.634)T(0.114)PRPR 68.676 0.026846 4736000.0 15949.0 16234.0 22004.0 32020.0 31059.0 25222.0 27546.0 20305.0 22316.0 26147.0 True False 15062.618428905613 17479.095599462707 20588.28659614377 27658.820762419047 27157.090749017043 28696.101557480124 28826.943581363506 20364.084188326306 26779.823561137382 25392.068171935345 0.5932017166507774 0.6883683314453892 0.8108156632510554 1.0892701049451747 1.0695107844359246 1.1301206882075314 1.1352735581115274 0.8019860395158267 1.0546531058362492 1.0 14.632090286148864 -5.500434367930594 2.404843741696081 1.0411474703651276 0.6323957868004219 0.7533102475246275 0.09283106656600544 0.1511405663212864 1.7183271253703134 0.02810252964569422 0.06778840255009752 3.159116428844435e-06 5.500434367930594 -0.4087516835647057 LSGEMPPAS(ph)PSFPR ddPTM_A459_Selumetinib_30min_R1 1 LSGEMPPASPSFPR 14 0 Q96JM7-2;Q96JM7 Q96JM7-2 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 1 LSGEMPPAS(0.86)PS(0.14)FPR 109.07 0.0046841 6839000.0 1936.1 2321.9 2316.2 2586.5 2458.0 1847.5 2109.6 2327.7 1084.7 1797.1 True False 1981.207363005201 2050.050868577974 2001.672761975892 2134.816329618224 2235.6743339951468 1828.9158273957844 1950.471173551295 2265.9618345648096 1840.6566766464994 2027.7752902363666 0.9770349666181515 1.0109852301923508 0.9871275045187912 1.0527874266430084 1.1025256815978592 0.9019321993920726 0.9618773751424593 1.1174620015715246 0.9077222143445411 1.0 10.98568207229745 -9.169877456380497 15.730811595242315 1.0000100366927005 1.0056775593677367 0.0 0.0689667597403485 0.0 0.0 0.0653488394354349 0.015849421617872173 6.762737706891009e-10 9.169877456380497 0.0056675226750362295 LSGEMPPAS(ph)PSFPR ddPTM_A459_Selumetinib_30min_R2 1 LSGEMPPASPSFPR 14 0 Q96JM7-2;Q96JM7 Q96JM7-2 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 1 LSGEMPPAS(1)PSFPR 160.87 0.00028748 4038500.0 17499.0 14783.0 17956.0 19075.0 19185.0 14116.0 14210.0 16258.0 12931.0 16269.0 True False 16526.47563404723 15916.808565163055 16800.730509014593 16476.952093789627 16774.808783923883 16060.350867710293 14870.793156580814 16305.30808834322 15517.561322327823 15799.271698061579 1.0460276872176881 1.0074393851405123 1.06338639084711 1.0428931414484879 1.0617456997072843 1.0165247597888165 0.9412328264729646 1.032029096021162 0.9821694074817183 1.0 13.947570435305497 -7.000361978967983 22.860741098844912 0.9897200458342847 1.042823337133974 0.518159255967349 0.025193148950607237 3.581977331148983 226267.117880055 0.008702926509138247 0.007573208719141831 9.991668598784638e-08 7.000361978967983 0.05310329129968916 LSGEMPPASPS(ph)FPR ddPTM_A459_Selumetinib_30min_R1 1 LSGEMPPASPSFPR 14 0 Q96JM7-2;Q96JM7 Q96JM7-2 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 1 LSGEMPPAS(0.397)PS(0.603)FPR 122.1 0.0018241 7709500.0 1860.7 2225.2 2563.3 2625.0 2732.5 1854.8 2487.4 2356.0 1173.3 1879.4 True False 1904.0506897080602 1964.6725495325857 2215.217939199035 2166.5930273527306 2485.345857462058 1836.1423960236548 2299.7734153827714 2293.5112266334536 1991.0044055585302 2120.639296906253 0.8978663615664538 0.9264529580295888 1.0445991180257577 1.0216697533208585 1.1719795351750135 0.8658438041313091 1.084471752804851 1.0815187806711868 0.9388699004414169 1.0 11.05028353597911 -5.184819628781733 4.342634097346724 1.030511643630602 0.9052643599555823 0.250070293362019 0.07902837572819556 0.2889280451012274 10.165875550342015 0.01974244315781413 0.057151531595838814 6.5340186721708826e-06 5.184819628781733 -0.1252472836750198 LSGFS(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 LSGFSFK 7 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 LSGFS(1)FK 96.034 0.023406 218860000.0 4328.9 7443.1 4474.4 5682.8 5413.2 5507.9 6958.8 7156.2 2951.9 5035.4 True False 4429.754947426893 6571.658391796689 3866.801056119909 4690.405659367658 4923.577015778085 5452.4955267730675 6433.892113437977 6966.394329386391 5009.158701754219 5681.742638949529 0.77964723658196 1.1566272549457983 0.6805660343733598 0.8255223718184542 0.8665610761786252 0.959651971807923 1.132380067575097 1.226101703662237 0.8816236531755932 1.0 12.472117769142693 -7.007990788656656 3.5481555908504543 1.077718878408458 0.8671629477582711 0.3017159156989889 0.14070494302182493 0.28655736797765574 7.711803146341034 0.054374290539701185 0.044177109772028905 9.817687660183436e-08 7.007990788656656 -0.21055593065018685 LSGFS(ph)FK ddPTM_A459_Selumetinib_30min_R2 1 LSGFSFK 7 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 LS(0.009)GFS(0.991)FK 91.265 0.028563 182590000.0 113920.0 75115.0 85075.0 90042.0 99128.0 71698.0 91384.0 100930.0 79170.0 64520.0 True False 107588.7824578923 80876.07896720726 79601.36712265623 77778.12426888617 86674.65442443614 81573.74869035804 95633.53707396073 101223.68959013901 95006.21219462501 62657.1399569078 1.717103310682327 1.2907719538879283 1.2704277146611185 1.24132899015783 1.3833164821127535 1.3019066741070542 1.5262991119564717 1.615517236499387 1.516287086515043 1.0 15.935191297612137 -7.258985669342741 24.907865194561527 1.4658189582371004 1.3545641169087093 0.0 0.20114832961425663 648.001336555592 6577982.3361133365 0.07692232457653245 0.056733030853129904 5.508258720140632e-08 7.258985669342741 -0.11125484132839114 LSGFS(ph)FKK ddPTM_A459_Selumetinib_30min_R2 2 LSGFSFKK 8 1 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 LSGFS(1)FKK;LSGFS(1)FKK 129.88 0.007118000000000002 559970000.0 1210840.0 1122720.0 1022920.0 1097590.0 900390.0 788440.0 883820.0 848680.0 703920.0 987370.0 True False 1143546.3601765675 1208829.0138862117 957106.4408710882 948096.3485516389 787274.9586112706 897040.453254287 924919.3812561067 851149.5182934627 844723.6691681243 958862.0626046489 1.1926077845547909 1.2606912516723767 0.9981690570499873 0.9887724058831089 0.821051316257857 0.9355260659886471 0.9646010801007806 0.8876662780686136 0.8809647415536709 1.0 19.870963765270147 -5.419983003257864 2.3568889862955227 0.9176098411063237 1.2339658377210005 0.8207982492954888 0.05501865078464046 0.11287318108465809 1.202425560483064 0.01517569852874737 0.04096905947353623 3.802042758731513e-06 5.419983003257864 0.31635599661467684 LSGINEIPRPFS(ph)PPVT(ph)SNTSPPPAAPLAR ddPTM_A459_Selumetinib_30min_R1 2 LSGINEIPRPFSPPVTSNTSPPPAAPLAR 29 1 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 2 LSGINEIPRPFS(0.995)PPVT(0.317)S(0.317)NT(0.202)S(0.168)PPPAAPLAR;LSGINEIPRPFS(0.751)PPVT(0.396)S(0.396)NT(0.396)S(0.06)PPPAAPLAR 98.377 4.2158e-07 109555000.0 3442.7 4200.4 4731.7 5126.700000000001 4343.4 3657.3 4205.5 3700.3999999999996 2397.78 2777.91 True False 3522.9082116719205 3708.6152152870163 4089.1611293676424 4231.418085077811 3950.5402368895516 3620.510882562711 3888.275749132527 3602.2533714068045 4068.8575330777608 3134.4818076348024 1.1239204525261592 1.1831669293003297 1.3045732533548235 1.349957774446529 1.2603487527881125 1.1550588278241287 1.240484388731073 1.1492340975253483 1.2980957564236155 1.0 11.614011241134966 -6.752398372566127 24.895547902188408 1.1823961053934062 1.2501999785907774 0.13439047471550092 0.09237265003373767 441.3474329486779 1215304.4539420705 0.030970450890588527 0.030541191247768943 1.7684860053257917e-07 6.752398372566127 0.06780387319737113 LSGINEIPRPFS(ph)PPVTS(ph)NTSPPPAAPLAR ddPTM_A459_Selumetinib_30min_R2 1 LSGINEIPRPFSPPVTSNTSPPPAAPLAR 29 1 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 2 LSGINEIPRPFS(0.98)PPVT(0.11)S(0.303)NT(0.303)S(0.303)PPPAAPLAR 63.893 0.0016243 12860000.0 22522.0 22379.0 26077.0 22167.0 27436.0 16400.0 18442.0 19330.0 18007.0 18507.0 True False 21270.31740270939 24095.39734017345 24399.23421049085 19147.816359792112 23989.24439904798 18658.951135622632 19299.58954212973 19386.24709974624 21608.903157617897 17972.654823039265 1.1834822185224871 1.3406698997682525 1.3575754083483154 1.0653860850455104 1.3347635413492729 1.0381855835624016 1.07383075745657 1.0786523911255939 1.2023211579135933 1.0 14.133515911220814 -6.5078534851971535 1.1506968531069588 1.0837335151269016 1.2781437627089238 0.3741405524454251 0.10236738280366411 0.5084306335178971 1.4189836012584405 0.04656872624510401 0.053849314743823644 3.105607127737197e-07 6.5078534851971535 0.1944102475820222 LSGINEIPRPFS(ph)PPVTSNTSPPPAAPLAR ddPTM_A459_Selumetinib_30min_R1 2 LSGINEIPRPFSPPVTSNTSPPPAAPLAR 29 1 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 LSGINEIPRPFS(0.998)PPVT(0.001)SNTSPPPAAPLAR;LSGINEIPRPFS(0.99)PPVT(0.007)S(0.003)NT(0.001)SPPPAAPLAR 127.4 6.4672e-14 479360000.0 3917.0 3952.0 5238.6 4972.9 4960.0 3932.7999999999997 4565.299999999999 4194.2 2474.0 3654.2999999999997 True False 4008.2584788447766 3489.298002765045 4527.226893570033 4104.476367894249 4511.368875759127 3893.239602696697 4220.935745455883 4082.956191318351 4198.197306189217 4123.365000896309 0.9720843238407196 0.8462258378791511 1.0979447350855274 0.9954191217614852 1.094098842760337 0.9441899035982533 1.0236628929377742 0.9902000406053857 1.0181483582648254 1.0 12.009606459124942 -5.256423113400956 24.995690539685448 1.019234374488094 0.9091550852542665 0.42181541617500373 0.05210833109139162 367.3388496675945 1830407.7423706495 0.01255582635083132 0.031097154371665457 5.540856294325618e-06 5.256423113400956 -0.11007928923382759 LSGINEIPRPFS(ph)PPVTSNTSPPPAAPLAR ddPTM_A459_Selumetinib_30min_R2 2 LSGINEIPRPFSPPVTSNTSPPPAAPLAR 29 1 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 LSGINEIPRPFS(0.996)PPVT(0.002)S(0.001)NTSPPPAAPLAR;LSGINEIPRPFS(0.928)PPVT(0.061)S(0.007)NT(0.003)S(0.001)PPPAAPLAR 96.133 9.3961e-08 122465000.0 112957.0 105063.0 126365.0 127717.0 129858.0 92496.0 94395.0 87513.0 82228.0 105286.0 True False 106679.30214269801 113120.99426920954 118234.8134758095 110321.72427588598 113544.07709475054 105236.48440491148 98784.55454014409 87767.6483414429 98675.89764228395 102246.11961411955 1.0433579537816149 1.1063597786999853 1.1563745785368857 1.0789820160632408 1.110497665077852 1.029246731338829 0.9661447780410687 0.8583958850730089 0.9650820785638639 1.0 16.641686566310973 -7.106968578383176 2.2236010061278426 0.9320175461317171 1.1017781522251968 0.7272739326127668 0.0435299581661944 0.15102427513827685 1.4685734686905136 0.0193194381279561 0.014100826186520666 7.816843581456265e-08 7.106968578383176 0.16976060609347976 LSGLAAPDYTRLS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 LSGLAAPDYTRLSPAK 16 1 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 LSGLAAPDY(0.008)T(0.388)RLS(0.604)PAK 73.76 0.018613 34519000.0 5896.2 5277.1 6286.5 7932.7 5877.3 5282.2 4937.6 5198.8 3417.7 4536.8 True False 6033.569987991977 4659.254678742768 5432.827829272709 6547.402860221339 5345.699252721595 5229.065863853866 4565.152856715434 5060.9109359176555 5799.5872810682595 5119.1424721742505 1.1786290420296393 0.9101631189342236 1.0612769343310007 1.279003836250032 1.044256783588037 1.0214730088637147 0.8917807780365368 0.9886247478805054 1.132921639237949 1.0 12.321686443567852 -6.517801808779136 23.588564628966772 1.0028074952376942 1.098869948717732 0.17260159542082798 0.10278486702573887 212.77666111651166 988620.0821185777 0.03500218006248944 0.03601781225709138 3.035276022924275e-07 6.517801808779136 0.09606245348003783 LSGLAAPDYTRLS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 LSGLAAPDYTRLSPAK 16 1 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 LSGLAAPDY(0.048)T(0.223)RLS(0.729)PAK 56.872 0.047423 15650000.0 71987.0 78703.0 61672.0 85567.0 69315.0 53852.0 72520.0 54088.0 44445.0 64578.0 True False 67986.25072679341 84739.26702996886 57704.09066339658 73912.62698869187 60607.03001603782 61269.624180216444 75892.32369565393 54245.38712524959 53335.24189705824 62713.465346205725 1.084077404293952 1.3512132771195322 0.9201228212289784 1.1785766673976934 0.9664117535438448 0.9769771745506544 1.2101439982098765 0.8649719294858186 0.8504591733629198 1.0 15.93648762006487 -5.657659441674095 0.4106144369096034 0.93540138850161 1.271627203539459 0.2451350358206279 0.1342802343792306 3.890499298034016 0.8691283265331229 0.11939725399232222 0.6016982847549679 2.1995840324510075e-06 5.657659441674095 0.3362258150378489 LSGLS(ph)FK ddPTM_A459_Selumetinib_30min_R2 2 LSGLSFK 7 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 LS(0.001)GLS(0.999)FK;LS(0.008)GLS(0.992)FK 97.965 0.022161 225920000.0 478360.0 323140.0 408810.0 422310.0 388850.0 339300.0 437610.0 496110.0 389600.0 383280.0 True False 451774.66622680356 347923.798941135 382507.6096786743 364790.64947461494 339999.18663689366 386035.495141266 457959.7321077648 497553.5979645687 467530.886333532 372213.7105189655 1.2137507390496411 0.9347420288630318 1.0276558838882006 0.9800569918985498 0.9134515388023827 1.0371340018695958 1.2303677139384426 1.3367417263347066 1.2560818506165956 1.0 18.505771672588885 -7.233331562288555 4.7709593484848245 1.235157632145221 1.0061834280733388 0.39550164854656855 0.11146565101743529 0.16852548308353466 10.136371826040888 0.04331096493716524 0.03188636754261615 5.843437963117362e-08 7.233331562288555 -0.22897420407188207 LSGS(ph)RQDLIPSYSLGSNK ddPTM_A459_Selumetinib_30min_R2 2 LSGSRQDLIPSYSLGSNK 18 1 Q9NQT8;H0YBA8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 LS(0.154)GS(0.846)RQDLIPSYSLGSNK;LS(0.181)GS(0.819)RQDLIPSYSLGSNK 151.3 6.7665e-05 18365100.0 121227.0 118725.0 104833.0 109306.0 110079.0 95723.0 88607.0 89035.0 61987.0 106276.0 True False 114489.68865013088 127830.82573895613 98088.15891354012 94418.33423663265 96249.89190125404 108907.97436312221 92727.40107143966 89294.07710946238 74386.13206149061 103207.53574179078 1.1093152048176627 1.2385803499733683 0.9503972574148214 0.9148395372296521 0.9325858931663316 1.0552327752073554 0.8984557222975386 0.865189508379139 0.7207432240955075 1.0 16.65518878803129 -5.345268005552603 5.27802990741023 0.9148758392216956 1.1728595613914168 0.5806412185638872 0.08754225810592675 0.14589707317682274 6.784183150293192 0.02402601528948048 0.051920844101834986 4.5157718756569416e-06 5.345268005552603 0.2579837221697212 LSGSNPYTTVTPQIINSK ddPTM_A459_Selumetinib_30min_R2 1 LSGSNPYTTVTPQIINSK 18 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 267.5 1.5625999999999993e-110 0.0 17883.0 19014.0 23407.0 19997.0 20150.0 15730.0 14349.0 19355.0 13137.0 13695.0 False True 16889.13445132101 20472.3126603538 21901.019103614668 17273.374103250913 17618.57685671444 17896.664717277064 15016.256932004102 19411.319845607257 15764.767078448729 13299.589766116742 1.269898902772875 1.5393191083615938 1.6467439589311033 1.2987899933017595 1.324745888147704 1.3456553947906162 1.1290767005656746 1.4595427518419644 1.1853573949034504 1.0 13.699094125161873 -9.047561841746187 0.18293156751269038 0.8105397094185239 1.564214776550879 0.46972334143961836 0.13327383632959716 6.9447960610215524 0.631484265943325 1.5273709028330866 0.6821301555579636 8.962685519111237e-10 9.047561841746187 0.753675067132355 LSHS(ph)DEKPYQCPVCQQR ddPTM_A459_Selumetinib_30min_R2 1 LSHSDEKPYQCPVCQQR 17 1 I3L2Z5;A0A087WWR2;P56270-3;P56270;P56270-2 I3L2Z5 MAZ Myc-associated zinc finger protein 1 LS(0.206)HS(0.781)DEKPY(0.013)QCPVCQQR 65.92399999999999 0.023278 3344800.0 4561.7 3717.4 4283.2 5532.1 4804.1 4316.2 4792.8 3684.3 4005.7 4004.9 True False 4308.178975931952 4002.5126266750444 4007.6235751955523 4778.618436595207 4200.566008801079 4910.717371437459 5015.674696753029 3695.0207030312995 4806.951928609429 3889.2681310201524 1.107709427789418 1.029117173678943 1.03043128943243 1.2286677790306473 1.080040220240427 1.26263276431635 1.289619159128898 0.9500555319291134 1.2359528236867972 1.0 11.925282984067394 -5.742416975796704 24.993111395081385 1.1551355317104206 1.053089051054834 0.13448358373355251 0.10835843466086985 459.2965686915643 603454.797883176 0.02870102986043211 0.04960355690989677 1.8096018192987675e-06 5.742416975796704 -0.10204648065558652 LSKPPFQTNPS(ph)PEMVSK ddPTM_A459_Selumetinib_30min_R2 2 LSKPPFQTNPSPEMVSK 17 1 Q4LE39-2;Q4LE39;H0Y7Y8;Q4LE39-4;Q4LE39-3 Q4LE39-2 ARID4B AT-rich interactive domain-containing protein 4B 1 LSKPPFQTNPS(0.995)PEMVS(0.005)K;LSKPPFQTNPS(0.998)PEMVS(0.002)K 95.307 0.012032 12903600.0 84035.0 82214.0 89950.0 92742.0 84434.0 78951.0 77212.0 83689.0 76014.0 86673.0 True False 79364.67111875865 88519.54944032426 84162.71493015498 80110.37961112651 73826.64607046277 89825.78360417939 80802.51099267547 83932.52113454031 91218.92400861712 84170.52528650135 0.9429033601562491 1.0516692053307215 0.9999072079410247 0.9517628568723454 0.8771080591355481 1.0671881076948084 0.9599858230376754 0.9971723575307281 1.0837395121169113 1.0 16.361027500401065 -8.042490528016433 10.079960885823558 1.0415274511907373 0.9805799656010936 0.172365636617288 0.05460327472286679 1.179788307774045 273.075912322132 0.03640503651461848 0.01391231884582492 9.06795741627033e-09 8.042490528016433 -0.06094748558964369 LSKS(ph)DEQLSSLDR ddPTM_A459_Selumetinib_30min_R2 1 LSKSDEQLSSLDR 13 1 Q13905-2;Q13905;Q13905-4;Q13905-3 Q13905-2 RAPGEF1 Rap guanine nucleotide exchange factor 1 1 LS(0.008)KS(0.992)DEQLSSLDR 107.63 0.031095 8351600.0 16766.0 9550.8 12290.0 12819.0 13807.0 9554.5 14257.0 9300.4 9947.1 12973.0 True False 15834.212839615731 10283.315649337714 11499.274780340244 11073.03008599157 12072.441223853897 10870.545647884535 14919.978749709559 9327.462624235892 11936.797945195816 12598.435782098031 1.25683958814281 0.8162374938601482 0.9127541687897747 0.8789210246025928 0.958249217018548 0.8628488358317647 1.1842723182278203 0.740366723739618 0.9474825408212676 1.0 13.620956999822326 -4.750318834692011 24.87686730468619 0.9200252921278802 1.2568403623945503 0.44309686509576707 0.11247139284543581 417.5818546987288 934074.4534422058 0.02659737269809171 0.39343326425439495 1.776974375963886e-05 4.750318834692011 0.3368150702666701 LSKS(ph)QGGEEEGPLSDK ddPTM_A459_Selumetinib_30min_R1 3 LSKSQGGEEEGPLSDK 16 1 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 LS(0.066)KS(0.933)QGGEEEGPLS(0.001)DK;LS(0.055)KS(0.945)QGGEEEGPLSDK;LS(0.007)KS(0.993)QGGEEEGPLSDK 194.67 5.7981e-06 26015200.0 6285.01 7476.51 10796.0 12496.9 8571.789999999999 8122.26 6897.0 6194.02 4468.450000000001 4960.15 True False 6431.438504499414 6601.156733464801 9329.962498183113 10314.551010866418 7796.473107972436 8040.557438822024 6376.753737193442 6029.734468587497 7582.6332873246565 5596.833568452457 1.1491209137879952 1.1794448866004144 1.6670073147740354 1.8429261625727464 1.3930149990377838 1.436626145923661 1.1393502521027503 1.0773474670705168 1.3548077130728902 1.0 12.450395131995743 -7.240151346756666 5.403526637614257 1.1481630436149222 1.4600981022725041 0.3309230954389024 0.20961828274285624 0.2409740551669549 22.834160914851733 0.09225739196796613 0.06809046209611543 5.752394379100395e-08 7.240151346756666 0.311935058657582 LSLEGDHS(ph)TPPSAYGSVK ddPTM_A459_Selumetinib_30min_R1 3 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHS(0.978)T(0.021)PPSAYGSVK;LSLEGDHS(0.99)T(0.01)PPSAYGSVK;LSLEGDHS(0.998)T(0.001)PPSAYGSVK 257.46 1.8944e-42 148609000.0 16663.9 21311.6 17863.2 17856.8 22396.5 17613.3 22396.3 19368.4 7094.799999999999 15188.5 True False 17052.13644769504 18816.427964505943 15437.475555533953 14738.44509365038 20370.740529423234 17436.12619359685 20706.929059635433 18854.68711457021 12039.357416310128 17138.091923518474 0.994984536422898 1.097930157480618 0.9007697954023237 0.8599816805408147 1.1886236005928186 1.0173901663854064 1.208240050995378 1.1001625617783077 0.7024911215342828 1.0 14.064918874897623 -8.242988559903198 24.954124267342117 0.8512455190911422 1.0459061072027307 0.2805214632357045 0.12476588244154954 909.4760934077224 1230040.8742978515 0.08591642120985292 0.032345697576488 5.7149369064401106e-09 8.242988559903198 0.19466058811158848 LSLEGDHS(ph)TPPSAYGSVK ddPTM_A459_Selumetinib_30min_R2 2 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LS(0.014)LEGDHS(0.949)T(0.037)PPSAYGSVK;LSLEGDHS(0.942)T(0.058)PPSAYGSVK 159.64 1.5045e-05 61543000.0 238806.0 148334.0 235297.0 283841.0 260679.0 182211.0 275932.0 263851.0 222462.0 195306.0 True False 225534.11853616076 159710.7408310153 220158.24719200344 245181.36614696367 227930.17352017152 207308.91130322777 288763.3847488853 264618.76272711525 266960.6161076242 189667.00831407076 1.1891056886535452 0.8420586281750663 1.1607619540634186 1.292693802292523 1.2017386447238128 1.0930151381939008 1.5224755602762514 1.3951754977277409 1.4075226813593351 1.0 17.53310922497812 -5.84689994245494 0.9023883739303022 1.3229368344133206 1.0019216862970488 0.2234211199397229 0.17039532099372853 0.9127864017153401 1.4198191008013334 0.07406874469235214 0.20971227976439957 1.4226565166425672e-06 5.84689994245494 -0.32101514811627174 LSLEGDHST(ph)PPSAYGSVK ddPTM_A459_Selumetinib_30min_R1 1 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHS(0.316)T(0.684)PPSAYGSVK 150.01 0.00036293 52123000.0 991.05 1718.9 1555.6 1882.3 1676.4 1424.8 1610.5 1294.4 555.24 1227.6 True False 1014.1395367523903 1517.6503889050703 1344.3580642991533 1553.5916401470654 1524.769915992458 1410.4678056148928 1489.0186883790107 1260.0683071962412 942.2017268748987 1385.1744178366046 0.732138511723524 1.0956384765431704 0.9705334194655435 1.1215855708434888 1.1007782820403778 1.0182600742928765 1.0749683716398635 0.9096820522893018 0.6802043950150695 1.0 10.43585193306999 -7.967459611833608 5.896437642387406 0.8250981284718353 1.023678702225197 0.2398874504142019 0.12763224890108638 0.2007144974927374 19.827948081597157 0.07042801620153294 0.03214635795177653 1.0778054819148212e-08 7.967459611833608 0.1985805737533617 LSLEGDHST(ph)PPSAYGSVK ddPTM_A459_Selumetinib_30min_R2 1 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHS(0.056)T(0.944)PPSAYGSVK 93.255 0.0063487 8187800.0 48072.0 44723.0 45540.0 64506.0 52547.0 30182.0 43801.0 41667.0 38705.0 52541.0 True False 45400.350687463164 48153.11029288964 42610.00598020298 55720.171520943266 45945.57608385969 34339.296535083064 45837.833290034956 41788.244071656794 46447.08150805799 51024.00481208763 0.8897841487485079 0.9437344338263728 0.8350972476019489 1.0920383793108908 0.9004698132392608 0.6730027692171284 0.8983582033367936 0.8189918495334793 0.9102986266780579 1.0 15.638888518313225 -6.528699408554301 24.998856854302353 0.8440431748200379 0.9408314192989526 0.11657640504987432 0.09909709326512864 271.3803722948503 1165525.6155199364 0.03163390115424414 0.03171895162935927 2.96006052624349e-07 6.528699408554301 0.09678824447891476 LSLEGDHSTPPSAY(ph)GSVK ddPTM_A459_Selumetinib_30min_R1 3 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHSTPPS(0.013)AY(0.725)GS(0.261)VK;LSLEGDHSTPPS(0.001)AY(0.638)GS(0.361)VK;LSLEGDHSTPPS(0.001)AY(0.545)GS(0.454)VK 133.86 0.0027052 43978500.0 10290.5 14685.400000000001 12328.5 15128.199999999999 19135.5 13868.599999999999 16568.1 12693.099999999999 2649.1400000000003 6638.9 True False 10530.248628172629 12966.026540942756 10654.357415603057 12486.3438614848 17404.69740364693 13729.094475681282 15318.354877946162 12356.437755000468 4495.397094469726 7491.067483362202 1.405707350996437 1.7308650028504666 1.4222749213335188 1.6668310476734054 2.3233934872837656 1.832728714054953 2.044882776983188 1.6494895797487263 0.6001010008859331 1.0 12.870955603241741 -8.192638493998148 5.50647729338121 0.8039676995751084 1.781170273802493 0.6660503023436373 0.2721628280297079 0.12190584836328464 6.916628778884507 0.20602133802349795 0.07366836938106122 6.417435405709974e-09 8.192638493998148 0.9772025742273847 LSLEGDHSTPPSAY(ph)GSVK ddPTM_A459_Selumetinib_30min_R2 2 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHSTPPS(0.065)AY(0.645)GS(0.291)VK;LSLEGDHSTPPS(0.006)AY(0.992)GS(0.003)VK 159.58 0.00021269 24648400.0 44831.0 32589.0 46169.0 63592.0 58338.0 33803.0 35502.0 32341.0 36457.0 43198.0 True False 42339.472492712215 35088.47150984909 43198.53680500644 54930.6598976812 51009.05889166287 38459.05641691779 37152.913345878405 32435.10695565924 43749.41869368997 41950.76149811693 1.0092658864991695 0.8364203713304258 1.029743805888852 1.3094079329202857 1.2159268883343761 0.916766586433577 0.8856314407438375 0.7731708745529011 1.0428754361384782 1.0 15.356409378524102 -6.884183104898535 10.23966092845985 0.9058178410655893 1.0764325262908043 0.2451087857210188 0.13553626228531412 0.49191212172294757 41.893563507827714 0.053207148784584817 0.04693264499542114 1.3056203034779044e-07 6.884183104898535 0.17061468522521506 LSLEGDHSTPPSAYGS(ph)VK ddPTM_A459_Selumetinib_30min_R1 2 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHSTPPS(0.172)AYGS(0.827)VK;LSLEGDHST(0.002)PPS(0.005)AYGS(0.993)VK 125.04 0.00055891 42140000.0 8471.3 9009.5 9892.8 14965.599999999999 11940.7 8844.099999999999 8002.9 7518.3 1521.5 3797.0 True False 8668.664807719615 7954.663551597087 8549.412097260645 12352.138899104773 10860.66579330181 8755.136383800305 7399.2348098282455 7318.890261119819 2581.8743740367377 4284.381935912015 2.023317467347672 1.856665365176828 1.9954831817394296 2.8830620341217026 2.5349434190885 2.0435004429493286 1.7270250226309882 1.7082721313364535 0.602624698884866 1.0 12.064871381109958 -7.897441014747166 1.427327895478243 0.8128980136827413 2.2331973748510827 0.7251336386626174 0.32896638673008644 0.24276917596114478 0.8954550643887172 0.3094674455680536 0.10984024834670665 1.2663652517411962e-08 7.897441014747166 1.4202993611683414 up LSLEGDHSTPPSAYGS(ph)VK ddPTM_A459_Selumetinib_30min_R2 5 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 LSLEGDHSTPPS(0.001)AY(0.086)GS(0.913)VK;LSLEGDHSTPPS(0.157)AY(0.035)GS(0.808)VK;LSLEGDHSTPPS(0.058)AY(0.003)GS(0.939)VK;LSLEGDHST(0.002)PPS(0.476)AY(0.006)GS(0.516)VK;LSLEGDHSTPPS(0.013)AY(0.002)GS(0.985)VK 124.66 0.00056954 89553000.0 236465.0 264314.0 307670.0 364766.0 284389.0 147284.0 212598.0 214285.0 198756.0 259972.0 True False 223323.22194439528 284586.03389653674 287874.8471657677 315084.24154355266 248661.5113500822 167571.03408896583 222484.2282549452 214908.53387320865 238512.7537066415 252465.93287162474 0.8845677490196346 1.1272254860668454 1.1402522466749914 1.2480267652735881 0.9849309509672458 0.663737210731609 0.8812445533713857 0.8512377548478453 0.9447324278318444 1.0 17.9457292017349 -6.523959871460906 24.99993861163827 0.8557781078369933 1.1062907742234298 0.4639706503755393 0.117091212682665 30.401710240538883 702981.3065695011 0.038317890972477606 0.03861719807033563 2.992541132767045e-07 6.523959871460906 0.25051266638643654 LSLEGDHSTPPSAYGSVK ddPTM_A459_Selumetinib_30min_R1 1 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 100.58 0.0038671 34524000.0 3444.0 3754.5 3796.4 3603.1 5283.3 3527.9 4339.1 3789.5 1010.2 1896.3 False True 3524.238499142559 3314.9213945803035 3280.8697321324917 2973.886223563665 4805.426447842374 3492.412529076909 4011.7981935705466 3688.9901499692155 1714.2356179112148 2139.7085765261927 1.647064716104538 1.5492396632638934 1.533325504288518 1.3898557290412679 2.245832213115658 1.632190741949927 1.8749273791684675 1.724061954249057 0.8011537817426841 1.0 11.063198602863125 -8.258130399173616 24.967520117497134 0.9005768273812914 1.7004955166785407 0.6700398418078282 0.2242733917654711 156.381525476345 1179982.446998853 0.1705631688008705 0.05847264703559522 5.519117000457834e-09 8.258130399173616 0.7999186892972493 LSLEGDHSTPPSAYGSVK ddPTM_A459_Selumetinib_30min_R2 2 LSLEGDHSTPPSAYGSVK 18 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ; 77.505 0.019264 33441000.0 139880.0 120521.0 194691.0 244760.0 247150.0 133703.0 141998.0 145985.0 135249.0 181748.0 False True 132106.02958400632 129764.57316390576 182164.7930235329 211423.26576544973 216100.80745096644 152119.37461500926 148601.1883636989 146409.79218088242 162302.57917280286 176500.4630019849 0.7484741248668604 0.7352081176265608 1.0320924371823563 1.1978623861347724 1.2243639692239006 0.8618638842511056 0.841930869960538 0.8295150601346349 0.9195589428622497 1.0 17.429312442464663 -10.484763402234403 17.74240920584794 0.9999999931771246 0.9381013559186553 0.014345932064004585 0.16204205380800382 0.0 0.0 0.17785636131973667 0.04313650375937021 3.275190742513373e-11 10.484763402234403 -0.061898637258469336 LSLFPAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LSLFPASPR 9 0 Q53GA4 Q53GA4 PHLDA2 Pleckstrin homology-like domain family A member 2 1 LSLFPAS(1)PR 112.83 0.0094646 9388700.0 3784.7 4219.4 4675.4 4538.0 4146.1 3708.0 3807.9 3480.4 2421.6 2843.4 True False 3872.8761462557627 3725.390686454158 4040.506360133875 3745.5234888101672 3771.0859870534073 3670.700886594626 3520.6670372421227 3388.0884860675183 4109.27833333379 3208.3780870614232 1.2071133891214667 1.1611445363866921 1.2593610386594443 1.1674196080302741 1.175387028810988 1.1440986027792777 1.0973354578876104 1.0560128495238206 1.280796159874508 1.0 11.647628448957263 -6.6968950866322166 1.6472155316906534 1.1137268508773253 1.2009859041671593 0.24765525933637744 0.07116024834409465 0.5609667024182382 3.1507747676125657 0.028716289838652726 0.027498818700141158 2.0095782117177357e-07 6.6968950866322166 0.08725905328983408 LSLFSDGDSS(ph)ESEDTLSSSER ddPTM_A459_Selumetinib_30min_R1 2 LSLFSDGDSSESEDTLSSSER 21 0 M0QZ79;M0QXD7;M0R025;M0QYG0;M0QYA8;Q8IV63-2;Q8IV63 M0QZ79 VRK3 Inactive serine/threonine-protein kinase VRK3 1 LSLFSDGDS(0.024)S(0.488)ES(0.488)EDTLSSSER;LSLFSDGDS(0.272)S(0.674)ES(0.054)EDTLSSSER 195.48 1.8386e-16 10391400.0 2024.58 2386.75 2473.12 2750.6 2539.3900000000003 2031.19 2160.23 2369.13 1154.82 2055.12 True False 2071.7487748530903 2107.308200430028 2137.283887875754 2270.2593451567327 2309.7026228657196 2010.7580727729603 1997.2821118888492 2306.2929763812035 1959.6451952843286 2318.9146705639996 0.8934131131048498 0.9087476254214627 0.9216742276057661 0.9790180613263216 0.9960274313603615 0.867111713206726 0.8613003907569725 0.9945570682944852 0.8450699890598861 1.0 11.179234018566195 -5.665616283957943 0.00490309955170409 1.8399403204402731 9.251622127550915e-08 0.05694385700541382 0.056180112186215374 90005.69299928624 94.79416969771157 17331.629840274043 18245.711567830316 2.1596517026012983e-06 5.665616283957943 -1.8399402279240518 LSLGQY(ph)DNDAGGQLPFSK ddPTM_A459_Selumetinib_30min_R2 1 LSLGQYDNDAGGQLPFSK 18 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 LS(0.003)LGQY(0.997)DNDAGGQLPFSK 105.46 0.02721 0.0 8530.9 8403.5 13308.0 12130.0 14429.0 12108.0 11048.0 14048.0 8081.4 13062.0 True False 8056.786729898474 9048.021428488653 12451.777768654836 10477.873074582865 12616.300023103346 13775.767094519439 11561.753891196679 14088.877354228405 9697.905813182277 12684.866120848266 0.6351495280392994 0.7132926230587281 0.981624689612582 0.8260136902321666 0.9945946534167808 1.086000196082339 0.9114604585533865 1.110683961502169 0.7645256734119757 1.0 13.630820672478496 -4.980145703522761 1.1616363994396801 0.975469915152692 0.5178780046768428 0.5463891595485187 0.10291743127728267 0.8264148898799668 1.1940997941815406 0.03089825685562633 0.42363179363963516 1.0467773008345934e-05 4.980145703522761 -0.45759191047584924 LSLLS(ph)STSK ddPTM_A459_Selumetinib_30min_R2 1 LSLLSSTSK 9 0 Q92754-2;Q92754;C9JXZ2;H7C5E5;C1K3N0;A0A6E1XE14;P05549-2;P05549-5;P05549-6;P05549;Q6VUC0;Q7Z6R9;Q92481;Q92481-2 Q92754-2 TFAP2C;TFAP2A;TFAP2E;TFAP2D;TFAP2B Transcription factor AP-2 gamma;Transcription factor AP-2-alpha;Transcription factor AP-2-epsilon;Transcription factor AP-2-delta;Transcription factor AP-2-beta 1 LSLLS(0.613)S(0.37)T(0.015)S(0.002)K 119.34 0.0069294 9809900.0 125370.0 116390.0 122490.0 137940.0 139900.0 105510.0 98656.0 120020.0 87538.0 122130.0 True False 118402.43729587417 125316.73874716419 114609.12675702796 119152.33404022761 122324.51127813155 120043.04477558192 103243.69948315542 120369.23832961934 105048.04601608022 118603.7895681519 0.9983023116461045 1.0565997865958145 0.9663192649605135 1.0046250164018622 1.031371018780489 1.012134985000652 0.8704924173087211 1.0148852643570296 0.8857056456507041 1.0 16.855790581317663 -7.105977036792273 24.999956681257032 0.9436247201959324 1.0121489778396644 0.3439298071301108 0.04653307817749258 34.60564366926296 8148.178779576395 0.01646669117994321 0.012755045044248438 7.834710674998749e-08 7.105977036792273 0.06852425764373204 LSLLSS(ph)TSK ddPTM_A459_Selumetinib_30min_R2 1 LSLLSSTSK 9 0 Q92754-2;Q92754;C9JXZ2;H7C5E5;C1K3N0;A0A6E1XE14;P05549-2;P05549-5;P05549-6;P05549;Q6VUC0;Q7Z6R9;Q92481;Q92481-2 Q92754-2 TFAP2C;TFAP2A;TFAP2E;TFAP2D;TFAP2B Transcription factor AP-2 gamma;Transcription factor AP-2-alpha;Transcription factor AP-2-epsilon;Transcription factor AP-2-delta;Transcription factor AP-2-beta 1 LSLLS(0.347)S(0.652)T(0.001)SK 147.28 0.0016555999999999995 8372000.0 131570.0 126640.0 152370.0 148560.0 157330.0 134040.0 105570.0 120090.0 105900.0 132410.0 True False 124257.86611644045 136352.88078821945 142566.68008791233 128325.87171970554 137564.79885195443 152502.7933060277 110479.21418298643 120439.4420180304 127082.95909322702 128586.97925750427 0.966333192006988 1.0603941516906112 1.1087178570577723 0.9979694091944111 1.069819041136906 1.1859893916679571 0.8591788594842422 0.9366379295437226 0.9883034800804726 1.0 16.97238503691854 -7.273336621621966 24.9977051460287 0.9407499013392039 1.0638440759090808 0.43839096317373916 0.06578089162514131 729.4334124194445 1532631.0760629121 0.0275375547529598 0.018728640778214106 5.3292166781520354e-08 7.273336621621966 0.12309417456987692 LSLPGLLSQVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 LSLPGLLSQVSPR 13 0 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 LSLPGLLSQVS(1)PR;LSLPGLLSQVS(1)PR 160.46 0.00036396 69734000.0 8795.3 10443.2 10659.6 9825.2 10266.0 9115.2 9486.3 8550.7 5191.1 8292.9 True False 9000.213377325359 9220.505289088038 9212.084868991547 8109.413261846123 9337.44211260951 9023.509363939416 8770.740753536053 8323.907659412009 8808.917557056924 9357.374494686524 0.9618310544732419 0.9853731187443437 0.9844732487967134 0.8666333987648948 0.9978698744943538 0.9643206402675569 0.9373078696931939 0.8895558967035724 0.9413877324306048 1.0 13.191888077842615 -7.325429365429309 5.930283313023414 0.9325010857791481 0.9597880563809711 0.023102039101825733 0.042318786287963116 0.6353227435683514 44.522810852063046 0.017883475527450367 0.012005774180584735 4.72683708922412e-08 7.325429365429309 0.027286970601822946 LSLS(ph)EGGLVPSSK ddPTM_A459_Selumetinib_30min_R2 1 LSLSEGGLVPSSK 13 0 Q8WUX9 Q8WUX9 CHMP7 Charged multivesicular body protein 7 1 LS(0.03)LS(0.97)EGGLVPSSK 115.06 0.0040766 1550500.0 15718.0 15721.0 17279.0 17130.0 17114.0 15435.0 17382.0 16283.0 14017.0 15406.0 True False 14844.456484139335 16926.750149017687 16167.287951952743 14796.864449101768 14963.986318898806 17561.031145020435 18190.29744177958 16330.380834204238 16820.79166770311 14961.188750404863 0.9921976610139105 1.131377354527369 1.0806151985426453 0.9890166280203738 1.0001869883831167 1.1737724480312581 1.215832361000548 1.091516262954862 1.1242951311103488 1.0 13.868937189546308 -6.762281569650886 24.99999760595407 1.1327248278159208 1.0433994812781808 0.26651864247078616 0.06674460842268667 30.081798303093542 892944.0143313695 0.02325701712849348 0.021699522930108447 1.7286952168755914e-07 6.762281569650886 -0.08932534653773994 LSMEDS(ph)KSPPPKATEEK ddPTM_A459_Selumetinib_30min_R1 1 LSMEDSKSPPPKATEEK 17 2 Q9NQG5 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 1 LS(0.008)MEDS(0.976)KS(0.016)PPPKATEEK 88.311 0.016337 0.0 2337.8 1687.1 3687.8 4021.8 2384.8 2581.1 1858.0 2071.9 1483.1 1673.5 True False 2392.266191433066 1489.5735476884888 3187.017015635391 3319.4681285360807 2169.095261070638 2555.1364774512913 1717.8495641156185 2016.946481520312 2516.7123786617713 1888.310026270414 1.2668821105388144 0.7888395056772185 1.6877615281903908 1.7579042012991561 1.1486965757179188 1.3531339885420832 0.9097285616327152 1.068122529383571 1.3327855826897819 1.0 10.8828799331774 -7.235203211528291 23.966116046418342 1.0833360349998835 1.3360389323503974 0.17522454573979496 0.27217997279662337 889.4497988694565 812491.7172732403 0.11122623032451143 0.08611897127423714 5.818309084989719e-08 7.235203211528291 0.2527028973505139 LSMEDSKS(ph)PPPK ddPTM_A459_Selumetinib_30min_R1 1 LSMEDSKSPPPK 12 1 Q9NQG5 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 1 LSMEDS(0.382)KS(0.617)PPPK 100.19 0.023507 0.0 2941.2 4014.4 3210.0 3135.8 2558.5 3164.9 3198.8 3179.2 2061.2 2800.4 True False 3009.7242374210505 3544.3921817560727 2774.09963126786 2588.1913962562658 2327.0841267398614 3133.0639794992803 2957.5119406313443 3094.8772885030053 3497.7058559083293 3159.8586182059526 0.9524869942218672 1.1216932812546037 0.8779189091829963 0.8190845569305067 0.7364519771017766 0.9915203045629031 0.93596337620653 0.9794353679849634 1.1069184664642349 1.0 11.625644293894776 -7.90107207412302 2.234195211588222 1.0529314422459153 0.9148655872803052 0.22148653929042927 0.09954619889757509 0.5313340437836191 5.080707067678325 0.08314396254715833 0.03095552578826451 1.2558215342754365e-08 7.90107207412302 -0.13806585496561008 LSMEDSKS(ph)PPPKATEEK ddPTM_A459_Selumetinib_30min_R1 1 LSMEDSKSPPPKATEEK 17 2 Q9NQG5 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 1 LS(0.001)MEDS(0.47)KS(0.53)PPPKATEEK 86.777 0.012424 39053000.0 2300.5 1479.3 3493.8 3402.6 2103.0 2135.1 1566.4 1849.5 1219.4 1357.7 True False 2354.09717400623 1306.1028682920883 3019.361150069672 2808.3997847125343 1912.7840213148063 2113.6228325156917 1448.2451868841256 1800.4452519773238 2069.2327385477483 1531.9740201179209 1.5366430129311381 0.8525620220319098 1.9708957922388672 1.8331902159126452 1.24857471223146 1.3796727651771794 0.9453457877651539 1.1752452902815793 1.3506970166429277 1.0 10.581176116282107 -6.742269754447997 2.2069248933335683 1.1449494235789355 1.519895789556817 0.25220413657161 0.3026538696196483 0.4878737236310226 4.882235585820274 0.1232281635722684 0.11501403497811259 1.810215359631721e-07 6.742269754447997 0.37494636597788156 LSMLS(ph)QEIQTLK ddPTM_A459_Selumetinib_30min_R1 2 LSMLSQEIQTLK 12 0 Q7Z674;F8W6C0;G3V0F5;Q9UHY8;Q9UHY8-2 Q7Z674 DKFZp779C2259;FEZ2 Fasciculation and elongation protein zeta-2 1 LS(0.012)MLS(0.988)QEIQT(0.001)LK;LSMLS(0.999)QEIQT(0.001)LK 99.927 0.013917 20706900.0 7077.0 4854.3 8670.9 9025.3 6360.5 5795.6 4747.1 5830.6 3996.5 4541.4 True False 7241.880330555137 4285.956299297157 7493.439405844383 7449.200780863465 5785.193898037483 5737.301525983768 4389.022425087862 5675.953547542026 6781.768607188843 5124.332926982045 1.4132337679355687 0.8363930213686083 1.4623248552778192 1.4536918047693363 1.1289652683524312 1.1196191987788602 0.8565061028680583 1.1076473032529632 1.3234441836281972 1.0 12.323148495022119 -6.499912398404916 20.362768557688955 1.0796879096729926 1.2736443213710076 0.19905989180395167 0.19915948173329084 134.6829662033774 119414.11352483835 0.06377897814392502 0.07152116873130432 3.162915587932784e-07 6.499912398404916 0.19395641169801503 LSMPQSAAVST(ph)TPPHNR ddPTM_A459_Selumetinib_30min_R2 1 LSMPQSAAVSTTPPHNR 17 0 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 LSMPQSAAVS(0.223)T(0.692)T(0.086)PPHNR 102.61 0.0056542 2604300.0 13467.0 12549.0 14134.0 17085.0 17780.0 11845.0 12166.0 14154.0 13593.0 13129.0 True False 12718.558052672372 13511.46794860523 13224.633827935646 14757.9935267311 15546.317444783259 13476.541231795734 12731.743106471657 14195.185796679158 16311.979820153278 12749.931656761359 0.9975393119795783 1.0597286567759776 1.0372317424087956 1.157495892843069 1.2193255511717949 1.0569892917542856 0.9985734393893746 1.1133538734814608 1.2793778240766447 1.0 13.638201893400977 -5.74134758368311 22.80250688604505 1.1193162207002172 1.0343225833160716 0.17871276100948585 0.08474761926803923 165.79639050357005 188159.83342927866 0.023861769273840233 0.041230068261546855 1.8140632124441376e-06 5.74134758368311 -0.08499363738414556 LSMPQSAAVSTT(ph)PPHNR ddPTM_A459_Selumetinib_30min_R2 5 LSMPQSAAVSTTPPHNR 17 0 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 LSMPQSAAVS(0.011)T(0.13)T(0.859)PPHNR;LSMPQSAAVS(0.005)T(0.24)T(0.755)PPHNR;LSMPQSAAVS(0.03)T(0.248)T(0.722)PPHNR;LSMPQSAAVS(0.002)T(0.026)T(0.972)PPHNR;LSMPQSAAVS(0.002)T(0.26)T(0.738)PPHNR 158.02 5.1881000000000014e-05 63613900.0 129187.0 103819.8 143111.0 155168.0 179042.0 135320.1 123860.7 149795.0 131802.0 133883.0 True False 122007.30371653578 111782.44482672788 133903.3940674754 134033.8507202702 156549.14330421152 153959.21546143718 129620.46797532104 150230.87865010282 158166.08285557543 130017.44992019059 0.9383917604246836 0.8597495558891824 1.0298878662031146 1.0308912442333318 1.204062557759032 1.184142709735831 0.9969467025763601 1.1554670449414288 1.216498884977851 1.0 16.988345737874063 -5.637246847999181 1.788406323707474 1.12778447939866 0.8989608376364662 0.5423959090260035 0.07829594072676177 0.26521674720106314 1.6956581076888035 0.02385600079780513 0.057390604995041984 2.305436432636837e-06 5.637246847999181 -0.22882364176219383 LSNRPAFMPSEGK ddPTM_A459_Selumetinib_30min_R2 1 LSNRPAFMPSEGK 13 1 O43707;O43707-2;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 106.54 0.01951 7770000.0 45427.0 31738.0 39760.0 42126.0 44805.0 36192.0 38498.0 34980.0 30139.0 42106.0 False True 42902.34919868926 34172.20254624536 37201.884887414824 36388.36612859668 39176.19533821787 41177.119481734975 40288.2332823398 35081.78600874926 36167.64215402044 40890.29037547365 1.0492062737813783 0.8357045702649778 0.9097975227324099 0.8899023654383912 0.9580806342650992 1.0070146018438004 0.9852762822761718 0.8579490555486889 0.88450440977338 1.0 15.319470687504664 -4.729791611268699 24.672087476859843 0.9247721578128106 1.0492072540076505 0.2970920466928163 0.05714302415275431 5148.182632540772 4013172.8494947003 0.015006414258934741 2.1529344031539273 1.8629808415191743e-05 4.729791611268699 0.12443509619483983 LSPAT(ph)PTSEGPK ddPTM_A459_Selumetinib_30min_R1 1 LSPATPTSEGPK 12 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 LSPAT(0.557)PT(0.379)S(0.063)EGPK 134.99 0.0055158 0.0 2000.6 2183.6 2663.6 2659.4 1949.8 1836.8 2133.4 2366.3 1317.4 1917.7 True False 2047.210087510048 1927.9430968719012 2301.8977501074974 2194.985713120706 1773.44093426515 1818.323459680963 1972.4759203898072 2303.5380371743395 2235.531580910942 2163.855474979845 0.9460937253811355 0.8909759081252221 1.0637945910546258 1.0143864682742505 0.8195745763850835 0.8403165002033695 0.9115562213821973 1.0645526301592743 1.0331242574931048 1.0 11.079388428700751 -7.757325321807581 24.99077937447614 1.036628843253856 0.9265054534866554 0.3221551617145132 0.07031170509930212 132.22607372271028 803221.2634584412 0.03850591924158798 0.021194634889671524 1.7485364022809993e-08 7.757325321807581 -0.1101233897672006 LSPAT(ph)PTSEGPK ddPTM_A459_Selumetinib_30min_R2 1 LSPATPTSEGPK 12 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 LS(0.021)PAT(0.96)PT(0.014)S(0.004)EGPK 96.756 0.039354 4010900.0 35678.0 33343.0 39008.0 41303.0 40213.0 27902.0 42723.0 38216.0 28344.0 32517.0 True False 33695.15959035011 35900.30088535694 36498.26774869915 35677.46014835085 35161.08343121872 31745.24723086236 44709.704154018495 38327.20223300063 34013.591997529926 31578.14972068774 1.0670403392341716 1.1368715774324687 1.1558076730755413 1.1298147758472858 1.1134624334301544 1.005291554814092 1.4158430607708439 1.2137253946798343 1.0771242868370676 1.0 14.94663902044389 LSPIAPAPGFS(ph)PSAAK ddPTM_A459_Selumetinib_30min_R2 2 LSPIAPAPGFSPSAAK 16 0 Q13118-2;Q13118 Q13118-2 KLF10 Krueppel-like factor 10 1 LSPIAPAPGFS(0.946)PS(0.054)AAK;LSPIAPAPGFS(0.956)PS(0.044)AAK 199.91 5.4329e-21 0.0 36421.8 38368.0 35351.3 41889.0 40403.0 32797.7 30445.0 30777.2 28064.0 35617.0 True False 34397.62216401744 41310.70222743531 33076.83584558519 36183.64593744447 35327.21393259716 37315.28546712258 31860.752825623014 30866.75655656026 33677.584173676245 34588.64466592043 0.9944773059555236 1.1943429014475957 0.9562917589013021 1.046113436560744 1.0213529403597714 1.078830518730578 0.9211333121998516 0.8923956649556934 0.9736601274480744 1.0 15.078010863278674 -7.265338274197657 24.972205987209314 0.9378302434190979 1.049651256636956 0.369514239646883 0.06469352635498708 335.7216351218179 2150264.6985857864 0.025532129988701333 0.01794407567692718 5.428273557755078e-08 7.265338274197657 0.11182101321785809 LSPLPPGS(ph)PGSAAR ddPTM_A459_Selumetinib_30min_R1 1 LSPLPPGSPGSAAR 14 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 LSPLPPGS(0.951)PGS(0.049)AAR 155.06 0.00033215 11993000.0 2545.6 2766.6 2980.7 2853.2 2554.3 2342.9 2232.0 2176.7 1238.6 1847.8 True False 2604.9075271246516 2442.685185842555 2575.937311813118 2354.942181197263 2323.2640159982916 2319.332553182995 2063.63844300649 2118.9668450819363 2101.813736235231 2084.9831290961874 1.2493662374399377 1.1715611276439568 1.2354715373307374 1.129477811275192 1.1142843237323439 1.1123987147984238 0.9897626576484817 1.0162992762442544 1.008072298957325 1.0 11.025819994630472 -6.570041179681423 0.7088555727861418 0.9920292834721138 1.2291963958628394 0.8923719063881359 0.030165783256833244 0.21467171779094257 0.2402916742538869 0.020207087002352377 0.02524196771056763 2.6912796054479924e-07 6.570041179681423 0.23716711239072552 LSPLPPGS(ph)PGSAAR ddPTM_A459_Selumetinib_30min_R2 4 LSPLPPGSPGSAAR 14 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 LSPLPPGS(0.939)PGS(0.061)AAR;LSPLPPGS(0.997)PGS(0.003)AAR;LSPLPPGS(0.997)PGS(0.003)AAR;LSPLPPGS(0.772)PGS(0.228)AAR 209.22 5.3624e-06 32097700.0 123886.0 126039.0 130277.0 141096.0 146765.0 106814.0 110281.0 114653.0 109636.0 130138.0 True False 117000.91207495144 135705.78602073947 121895.11965487264 121878.48139582398 128327.06860425285 121526.65893904837 115409.2850176558 114986.62124817415 131566.26348578878 126380.57780086935 0.9257823797838866 1.0737867193055828 0.9645083269593514 0.9643766749338727 1.0154018191501741 0.9615928416669449 0.9131884584314816 0.9098440856106229 1.0410322992278942 1.0 16.947415241248166 -6.9208790980040416 8.94728106715772 0.9555183717519793 0.9906957727035564 0.03499204087023178 0.05126062408410744 0.7304463619021783 75.04166010972031 0.01767797073250835 0.01559000939972279 1.1998332748066956e-07 6.9208790980040416 0.035177400951577065 LSPLPPGSPGS(ph)AAR ddPTM_A459_Selumetinib_30min_R1 1 LSPLPPGSPGSAAR 14 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 LSPLPPGS(0.235)PGS(0.765)AAR 125.33 0.0013880999999999998 11586000.0 1783.2 1950.2 2077.4 2072.2 2012.1 1852.3 2133.2 1660.6 736.76 1695.1 True False 1824.7450904968093 1721.8696773766178 1795.300490341385 1710.3291700115537 1830.1059102651084 1833.667543753837 1972.2910065508265 1616.5554936109986 1250.2279091786436 1912.6825966722306 0.9540239941909762 0.9002380637395888 0.9386295946148765 0.8942043875901102 0.9568267696110203 0.9586888838451987 1.0311648205417383 0.845177080830637 0.6536515318086991 1.0 10.90138176775559 -7.97511525380333 14.053355643910129 0.8010277896086391 0.9438061264801015 0.26367285919737593 0.08591973034846834 1.7949719325047742 1012.9013127774346 0.04408688996578586 0.021128638107163176 1.0589726559311012e-08 7.97511525380333 0.14277833687146246 LSPPVASGGIPHQS(ph)PPTK ddPTM_A459_Selumetinib_30min_R1 2 LSPPVASGGIPHQSPPTK 18 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 LSPPVASGGIPHQS(0.997)PPT(0.003)K;LSPPVASGGIPHQS(1)PPTK 216.35 3.6728e-14 33964000.0 5945.1 6744.700000000001 6447.0 6573.799999999999 6577.8 5509.3 6726.0 5774.6 2836.8 4583.7 True False 6083.60926284914 5955.027388474036 5571.532810836103 5425.809235509097 5982.839151404912 5453.881444044169 6218.652404866337 5621.438849455664 4813.842408325611 5172.06254401894 1.176244334068297 1.1513834834345789 1.0772361632167649 1.0490610253318753 1.1567607894308176 1.054488687564525 1.2023544479479837 1.0868853192729448 0.930739403739891 1.0 12.336524005943353 -8.148525561885029 4.968396346176277 0.9673462574581233 1.1203528325531749 0.5975312836776816 0.051083568830520384 0.14947629342493396 5.368113075356287 0.03653644439358173 0.01305365390544858 7.10353358499422e-09 8.148525561885029 0.15300657509505156 LSPPVASGGIPHQS(ph)PPTK ddPTM_A459_Selumetinib_30min_R2 2 LSPPVASGGIPHQSPPTK 18 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 LSPPVASGGIPHQS(0.998)PPT(0.002)K;LSPPVAS(0.002)GGIPHQS(0.996)PPT(0.002)K 102.61 0.0014936 32306900.0 127571.0 103472.0 161766.0 177171.0 175762.0 130210.0 143289.0 129868.0 112036.0 153242.0 True False 120481.11452717523 111407.96968508075 151358.15167750392 153040.0041629774 153681.2062277837 148145.2455713063 149952.2224217669 130245.89437919522 134446.33054739115 148817.5052894676 0.8095896668394302 0.7486214035665972 1.0170722280493445 1.0283736705926936 1.0326823173715727 0.9954826569841116 1.00762489016391 0.8752054681057285 0.9034308852703663 1.0 17.183184713980168 -5.260796769535227 24.998647746874806 0.9828209081262014 0.7791055208246884 0.7137029954138986 0.051524243535296464 31.556083814305403 1227522.3709956529 0.01497658110055766 0.035136654674150544 5.485335941493021e-06 5.260796769535227 -0.20371538730151295 LSPPYS(ph)SPQEFAQDVGR ddPTM_A459_Selumetinib_30min_R1 2 LSPPYSSPQEFAQDVGR 17 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 LSPPYS(0.618)S(0.382)PQEFAQDVGR;LSPPYS(0.937)S(0.063)PQEFAQDVGR 195.5 7.7055e-08 21509000.0 2153.2 2645.1 2952.7 3167.4 2981.8 2523.6 2620.6000000000004 2796.8999999999996 1761.25 2231.8 True False 2203.365370602138 2335.4104623263715 2551.7395580201255 2614.27304946173 2712.0967164795466 2498.21487524547 2422.926032142836 2722.717126388415 2988.7126133895545 2518.2732695729355 0.8749508630474397 0.9273856378273138 1.0132893792153326 1.0381212718447648 1.0769668046945045 0.9920348619151776 0.9621378511291314 1.0811841428353606 1.1868102836577379 1.0 11.298219129778692 -5.153395703755132 1.6072803924680146 1.0476938558084994 0.8611353704287867 0.5067287985832676 0.05838768768345934 0.491237315791268 1.948186804354999 0.018086361138403263 0.11463759972314329 7.024320132173188e-06 5.153395703755132 -0.18655848537971265 LSPPYSS(ph)PQEFAQDVGR ddPTM_A459_Selumetinib_30min_R2 1 LSPPYSSPQEFAQDVGR 17 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 LSPPYS(0.266)S(0.734)PQEFAQDVGR 104.16 0.0028918000000000004 4718900.0 17426.0 14943.0 15209.0 16642.0 16031.0 11453.0 12835.0 12504.0 12975.0 14021.0 True False 16457.532681805074 16089.080050681974 14230.469498307151 14375.330890948726 14017.042461041648 13030.546790017428 13431.852932070015 12540.384569851358 15570.36255179053 13616.177299067022 1.2086749695109171 1.1816150522499729 1.0451148795838772 1.0557537975018672 1.0294403600342434 0.9569900937548954 0.9864628402709154 0.9209915745376365 1.1435193747702894 1.0 13.733034107439444 -5.19948478874794 1.0889457511826868 0.9997281505415754 1.2569919331091413 0.6174899809943506 0.05650673016825508 0.598959108641869 0.9271641696284663 0.018425485190230354 0.1511508029781681 6.31706304541115e-06 5.19948478874794 0.2572637825675659 LSPS(ph)PSSR ddPTM_A459_Selumetinib_30min_R1 4 LSPSPSSR 8 0 Q03252;P20700 Q03252;P20700 LMNB2;LMNB1 Lamin-B2;Lamin-B1 1 LS(0.001)PS(0.956)PS(0.043)SR;LSPS(0.882)PS(0.118)SR;LS(0.021)PS(0.939)PS(0.039)SR;LS(0.002)PS(0.957)PS(0.04)SR 131.52 0.0035481 604434000.0 19962.4 18344.0 21528.0 21897.9 21334.5 16238.099999999999 17765.4 18193.6 10815.300000000001 14246.0 True False 20427.485079931314 16196.27595210576 18604.61584483939 18073.842839492332 19404.7982419119 16074.75945701516 16425.3415749944 17711.046626858413 18352.7741817414 16074.612867791038 1.2707917290414001 1.0075686478620272 1.1573912229088739 1.1243718892731274 1.2071704868733484 1.0000091193004352 1.0218187965139816 1.1018023744973868 1.141724179156759 1.0 13.97249637244056 -6.7637504828132045 24.995979886199116 1.0574802922358513 1.1439563130235233 0.30488905102881125 0.07495936261152417 91.84945896259981 993398.457476268 0.025496235737018525 0.0235511010102154 1.7228581322212864e-07 6.7637504828132045 0.08647602078767203 LSPS(ph)PSSR ddPTM_A459_Selumetinib_30min_R2 3 LSPSPSSR 8 0 Q03252;P20700 Q03252;P20700 LMNB2;LMNB1 Lamin-B2;Lamin-B1 1 LSPS(0.946)PS(0.054)S(0.001)R;LSPS(0.964)PS(0.036)SR;LS(0.002)PS(0.994)PS(0.004)SR 150.81 0.0012315 782150000.0 3605550.0 3034130.0 3430080.0 4250650.0 3892560.0 3113190.0 3284580.0 3212640.0 3559050.0 3092450.0 True False 3405167.9651602334 3266838.0147343664 3209392.387188725 3671704.1372197475 3403541.812872076 3542003.663774941 3437319.4782717996 3221988.2505188202 4270959.448165703 3003162.933349966 1.133860546607719 1.0877991262000148 1.0686707509434776 1.2226123652651897 1.133319066733251 1.179424407660729 1.1445664303127039 1.0728649500627523 1.422153756873103 1.0 21.518051318198367 -5.748264240053525 24.98872834110494 1.1689582460494217 1.0958790352105097 0.08860924737384723 0.10439845694858052 568.000661583161 1077293.6952769859 0.02674532213704281 0.04597774420691932 1.7854009435183672e-06 5.748264240053525 -0.073079210838912 LSPS(ph)PTSQR ddPTM_A459_Selumetinib_30min_R1 5 LSPSPTSQR 9 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 LS(0.023)PS(0.976)PT(0.001)SQR;LS(0.001)PS(0.995)PT(0.004)SQR;LS(0.005)PS(0.995)PT(0.001)SQR;LS(0.002)PS(0.99)PT(0.008)SQR;LS(0.024)PS(0.964)PT(0.012)SQR 149.94 0.0013723 4609551000.0 20915.899999999998 23083.0 24494.1 26055.800000000003 22697.0 18987.0 21473.699999999997 18994.8 11301.2 17266.2 True False 21403.199774743276 20380.431629004437 21167.935756460447 21505.643657941822 20644.060357480816 18796.008018816654 19853.921520424956 18490.996200194033 19177.31099300953 19482.48495703031 1.098586747119231 1.0460899456077908 1.086511079215382 1.1038450025945716 1.0596215217418326 0.9647644055813354 1.0190651533525559 0.9491087117981583 0.9843359835927575 1.0 14.249890081946205 -6.659974881567702 4.746923134752026 0.9826488926113213 1.0812166713491465 0.8148012350794805 0.022924496529209283 0.08709889955668206 3.300404006083345 0.007598682931627011 0.0075352079151551335 2.187888161894952e-07 6.659974881567702 0.09856777873782518 LSPS(ph)PTSQR ddPTM_A459_Selumetinib_30min_R2 9 LSPSPTSQR 9 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 LS(0.044)PS(0.949)PT(0.007)SQR;LS(0.001)PS(0.997)PT(0.001)SQR;LS(0.012)PS(0.915)PT(0.07)S(0.003)QR;LS(0.191)PS(0.809)PTSQR;LS(0.018)PS(0.97)PT(0.011)SQR;LSPS(0.999)PT(0.001)SQR;LS(0.226)PS(0.773)PT(0.001)SQR;LS(0.014)PS(0.979)PT(0.006)SQR;LS(0.077)PS(0.922)PT(0.001)SQR 160.72 0.00091234 6534155700.0 834051.0 738514.0 755113.0 816067.0 827936.0 551286.0 596598.0 628267.0 516515.0 715868.0 True False 787697.7843906925 795155.649103215 706529.8516848694 704917.2668059038 723923.2778382498 627220.6424239546 624340.9891365091 630095.1529547991 619832.4326349212 695199.0307915623 1.1330536285325512 1.143781296987484 1.016298671878765 1.0139790701423679 1.0413180194080274 0.9022173717788319 0.8980751719771914 0.9063521740491567 0.8915898975422509 1.0 19.407066545264065 -5.7180962433372295 0.6862205871597327 0.9111323804379409 1.1759652857016005 0.7589611677562109 0.0441132193029442 0.550876395821994 0.4266671739171614 0.02387281755044107 0.09586245628289058 1.913831756688837e-06 5.7180962433372295 0.26483290526365966 LSPS(ph)PTTEDPR ddPTM_A459_Selumetinib_30min_R1 2 LSPSPTTEDPR 11 0 F6RRE2;E7EV10;Q9BTC8;E7EQY4;Q9BTC8-2 F6RRE2 MTA3 Metastasis-associated protein MTA3 1 LS(0.127)PS(0.841)PT(0.022)T(0.01)EDPR;LS(0.041)PS(0.673)PT(0.234)T(0.051)EDPR 162.26 0.00062296 23778000.0 5136.3 6181.6 4315.9 4238.8 4661.2 4134.1 6184.5 5691.5 2664.8 4839.3 True False 5255.965796499982 5457.855398252128 3729.824485541731 3498.5731521305743 4239.595283001699 4092.514707462474 5717.998185830487 5540.542931402509 4521.970970708578 5460.471293773774 0.962548013482467 0.9995209396074238 0.6830590776650747 0.6407090091508719 0.7764156342760812 0.7494801249351694 1.0471620265361261 1.0146638693476944 0.828128329484067 1.0 12.414809760321287 -7.256307635011765 24.98406471213593 0.973710546776157 0.7970410455058258 0.3362661183901917 0.11724646325814142 551.4670811298206 2684844.7722269245 0.05065320768285406 0.03802872430278695 5.542329797354976e-08 7.256307635011765 -0.1766695012703312 LSPS(ph)PTTEDPR ddPTM_A459_Selumetinib_30min_R2 1 LSPSPTTEDPR 11 0 F6RRE2;E7EV10;Q9BTC8;E7EQY4;Q9BTC8-2 F6RRE2 MTA3 Metastasis-associated protein MTA3 1 LSPS(0.994)PT(0.005)T(0.001)EDPR 152.67 0.00057414 15775000.0 44725.0 31953.0 36531.0 41147.0 38414.0 35252.0 40146.0 43437.0 36777.0 32516.0 True False 42239.363548360605 34403.69235491142 34180.63523194546 35542.70761746585 33588.0898944828 40107.643014205394 42012.86854778984 43563.39447861756 44133.42763523702 31577.17859328605 1.3376547693637693 1.089511282753626 1.0824474115370446 1.125582119772504 1.0636824248010655 1.270146504562415 1.3304820259249706 1.3795847640384193 1.3976368251158666 1.0 14.946594652352582 -6.894640931812071 5.768612747660133 1.307349836442085 1.1336179685651528 0.20846447433486104 0.12637382468606959 0.26164291961546676 12.472006206591555 0.043354782600971906 0.03820032168169041 1.2745564297204352e-07 6.894640931812071 -0.17373186787693218 LSPSPTT(ph)EDPR ddPTM_A459_Selumetinib_30min_R2 1 LSPSPTTEDPR 11 0 F6RRE2;E7EV10;Q9BTC8;E7EQY4;Q9BTC8-2 F6RRE2 MTA3 Metastasis-associated protein MTA3 1 LS(0.003)PS(0.134)PT(0.066)T(0.798)EDPR 119.39 0.011774 15485000.0 27640.0 23775.0 28909.0 29990.0 34761.0 21815.0 27117.0 27170.0 24707.0 20184.0 True False 26103.879451686673 25598.466051325977 27049.02641373931 25905.31026436438 30394.01241271714 24819.818233146805 28377.994231316137 27249.060201764372 29649.090371259244 19601.23547566998 1.3317466383222678 1.3059618656742356 1.3799653826573277 1.3216161959035353 1.5506171766796888 1.2662374401835226 1.4477655893956431 1.3901705448917876 1.512613345626155 1.0 14.258656970545433 -10.713791397993523 5.048112777976175 0.9999680734534988 1.3877181392175095 0.6463180744656813 0.08645845772126234 3.002123833969221e-05 4.811610743124203e-06 0.0808968704289578 0.019618760476302982 1.9328965104154805e-11 10.713791397993523 0.3877500657640107 LSPVIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LSPVISPR 8 0 Q08499-6;Q08499-7;Q08499-12 Q08499-6 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 LS(0.007)PVIS(0.993)PR 81.525 0.043521 7321400.0 3926.3 3998.4 3523.6 3801.1 3923.1 3885.5 4148.1 4381.9 2239.9 3281.3 True False 4017.775150750127 3530.2654691942685 3045.1144737493537 3137.3092404839867 3568.256297679562 3846.4153977517317 3835.2054773455297 4265.677777582826 3800.9467041767293 3702.4868175686333 1.0851558286947633 0.9534849529896612 0.8224511318446864 0.8473519002409872 0.9637458479927233 1.0388734888940439 1.0358458156142878 1.152111536857282 1.0265929067298485 1.0 11.854278883576017 -6.725667987044074 2.9217197617393316 1.062691579280841 0.9201709570808662 0.37258101885869255 0.07582755834793158 0.27117824559780085 4.741008347357611 0.02943815020675419 0.027937895032134605 1.8807540814297299e-07 6.725667987044074 -0.14252062219997474 LSPVIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LSPVISPR 8 0 Q08499-6;Q08499-7;Q08499-12 Q08499-6 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 LSPVIS(1)PR 84.81700000000002 0.036143 13349000.0 35796.0 25811.0 31595.0 30650.0 32921.0 25796.0 21518.0 29158.0 28162.0 31577.0 True False 33806.60162274156 27790.62070455415 29562.212098034983 26475.417125800894 28785.16966252584 29349.164847226897 22518.629637108097 29242.84495263324 33795.18691202506 30665.289963101026 1.1024386745868184 0.9062565766700424 0.9640284547645447 0.8633675780551324 0.9386889769235022 0.9570809499124973 0.7343361065297066 0.9536138411807165 1.1020664390485198 1.0 14.90431897234609 -8.016867616491274 24.091197095803835 1.0433022703080788 0.9184273168395906 0.23674688318126536 0.08957782727071747 647.246587520472 924423.0984584166 0.057180313259501216 0.0228298442616186 9.619054458472985e-09 8.016867616491274 -0.1248749534684882 LSPYPSS(ph)PMR ddPTM_A459_Selumetinib_30min_R2 1 LSPYPSSPMR 10 0 A0A0A0MRE6;O94967-2;O94967;O94967-3;O94967-4 A0A0A0MRE6 WDR47 WD repeat-containing protein 47 1 LS(0.005)PYPS(0.131)S(0.864)PMR 84.507 0.037773 8932300.0 56573.0 60332.0 64703.0 66062.0 71643.0 57959.0 53252.0 62878.0 42876.0 59334.0 True False 53428.899139662455 64959.270402044094 60540.07942329986 57064.24163669364 62642.56584345374 65942.32615058232 55728.323516836186 63060.9645699867 51452.39805553536 57620.87325175399 0.9272490353664689 1.1273565764653997 1.050662303550858 0.9903397573891609 1.0871505811749718 1.1444173340183632 0.9671551361839141 1.0944118166079184 0.892947210826402 1.0 15.814303904442033 -8.258033333736291 24.999175048646272 0.9464736043578243 1.0511103106033017 0.2514996501627935 0.07036129517854142 362.11152301345305 2657824.6765657626 0.04940667373957421 0.016974735883268324 5.5203506688526084e-09 8.258033333736291 0.10463670624547738 LSQMQS(ph)PIPLTETR ddPTM_A459_Selumetinib_30min_R2 1 LSQMQSPIPLTETR 14 0 H3BSW6;Q2VPK5-3;Q2VPK5;Q2VPK5-5 H3BSW6 CTU2 Cytoplasmic tRNA 2-thiolation protein 2 1 LSQMQS(0.999)PIPLT(0.001)ETR 130.87 0.00093601 7873200.0 21424.0 21994.0 22503.0 26814.0 21794.0 15255.0 16887.0 17597.0 14788.0 24700.0 True False 20233.339847067138 23680.869078143576 21055.181479413877 23161.88694326999 19056.04287916796 17356.23777889774 17672.278960955686 17648.204356659822 17746.013211243047 23986.846821692874 0.8435181163023397 0.987243936402988 0.8777802950061906 0.9656078231309329 0.7944371772088998 0.7235731277193699 0.7367487311826867 0.7357450726161888 0.7398226762841612 1.0 14.549955900928536 -6.369662359877904 5.211250987949545 0.7669280933393616 0.9200323070887441 0.34400679082703745 0.08559758836062191 0.21216858595011298 8.493687971775307 0.025052864034211683 0.02848589254355071 4.269112899135401e-07 6.369662359877904 0.15310421374938243 LSQNSVNLS(ph)PSSHANNLSVVTYSK ddPTM_A459_Selumetinib_30min_R2 2 LSQNSVNLSPSSHANNLSVVTYSK 24 0 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 LSQNS(0.005)VNLS(0.705)PS(0.268)S(0.021)HANNLSVVTYSK;LS(0.002)QNS(0.048)VNLS(0.614)PS(0.196)S(0.14)HANNLSVVTYSK 103.18 1.4888999999999996e-06 22951000.0 52592.0 53684.0 79592.0 92572.0 95384.0 72898.0 56956.0 62386.0 68409.0 86959.0 True False 49669.14718245682 57801.39017873324 74471.13737321731 79963.533904393 83401.00917622088 82939.03779784263 59604.56685617292 62567.53293144174 82092.71150716275 84448.26772338405 0.5881606398979247 0.6844591575053447 0.8818551212578155 0.9468937144610107 0.9875988155187085 0.9821283495064101 0.7058115987815364 0.7408977663862316 0.9721065182303433 1.0 16.365780209059054 -5.15104723778684 2.8567274394651827 0.8948782492516999 0.5991217874018253 0.5494754730945506 0.09792590426392227 0.23570030029286995 3.571039725680734 0.028551203195399395 0.10590416706602394 7.062407329700533e-06 5.15104723778684 -0.2957564618498746 LSQNSVNLSPS(ph)SHANNLSVVTYSK ddPTM_A459_Selumetinib_30min_R1 1 LSQNSVNLSPSSHANNLSVVTYSK 24 0 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 LSQNS(0.004)VNLS(0.07)PS(0.463)S(0.463)HANNLSVVTYSK 94.542 8.2685e-06 21681000.0 1826.5 2165.4 2458.0 2452.6 2775.0 1811.9 2249.4 2141.6 734.81 1390.1 True False 1869.0538962496753 1911.8739613328507 2124.2171008275377 2024.299451003926 2524.001739966042 1793.673931073571 2079.7259469976693 2084.7978111028037 1246.918901601009 1568.5328757206453 1.1915937021026473 1.2188931395234297 1.354270053059353 1.2905687106327839 1.6091481275497124 1.143536076825605 1.325905232328753 1.3291387406495807 0.7949587292061863 1.0 10.615200052378563 -8.254162255191911 24.714385935146375 0.8974793533511591 1.3110494366350125 0.6222605273357895 0.12788369670192756 269.9140846989438 916684.320198479 0.0894302700810025 0.032248834389258525 5.5697761965948765e-09 8.254162255191911 0.41357008328385336 LSQSSQDS(ph)SPVR ddPTM_A459_Selumetinib_30min_R2 1 LSQSSQDSSPVR 12 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 LSQS(0.001)S(0.011)QDS(0.811)S(0.177)PVR 113.37 0.0059856 14993000.0 56231.0 53307.0 61398.0 61991.0 67429.0 47150.0 45978.0 55542.0 43966.0 59769.0 True False 53105.90613052802 57395.47549097928 57447.71952508792 53547.71885956031 58957.96619709164 53644.484514915035 48116.06810367861 55703.618024526935 52760.428512679944 58043.313671488286 0.9149358086461974 0.9888387113083237 0.9897387983434012 0.9225475851125247 1.0157581031775698 0.9242147134901773 0.8289683179703422 0.959690522491471 0.9089837429215664 1.0 15.824842264235961 -6.973817003657358 24.869007503086635 0.9147000844238904 0.96682777013892 0.14008186698692782 0.0497392321448769 330.5051834372843 313917.90716932935 0.016858036430332724 0.014866990332701427 1.0621430124405591e-07 6.973817003657358 0.05212768571502957 LSQSSQDSS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 5 LSQSSQDSSPVR 12 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 LSQSSQDS(0.083)S(0.917)PVR;LSQSSQDS(0.004)S(0.996)PVR;LSQSSQDS(0.109)S(0.89)PVR;LSQSSQDS(0.093)S(0.907)PVR;LSQSSQDS(0.003)S(0.997)PVR 203.85 4.1404e-05 476266000.0 18160.2 21092.899999999998 21272.5 23484.700000000004 21861.9 17718.4 19215.2 17788.5 9504.05 14932.099999999999 True False 18583.29732640206 18623.333462176823 18383.811341478362 19383.53800741741 19884.495005031935 17540.168983020016 17765.781993753728 17316.69119480867 16127.67870165223 16848.78048597098 1.1029461355897723 1.1053223393635767 1.091106347832445 1.1504416016077235 1.1801741391068998 1.0410349281732714 1.054425393490424 1.0277711914655956 0.9572015443539567 1.0 14.040356552528536 -7.409954768143828 1.3089699490986595 0.9875896242411379 1.1214170687583875 0.7266936359455773 0.033826074540136655 0.2547662220571532 0.8353818645738949 0.024625150323183194 0.012556225838550752 3.890856662331767e-08 7.409954768143828 0.1338274445172496 LSQSSQDSS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 4 LSQSSQDSSPVR 12 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 LSQSSQDS(0.322)S(0.678)PVR;LSQSSQDS(0.033)S(0.967)PVR;LSQSSQDS(0.02)S(0.98)PVR;LSQSSQDS(0.017)S(0.983)PVR 161.49 0.00048262 737850000.0 279387.0 287200.0 321790.0 337649.0 338602.0 237257.0 273149.0 267000.0 247831.0 289135.0 True False 263859.7890147752 309227.316506448 301086.3817384611 291660.62372298696 296063.78961971315 269936.99814539147 285850.9697344751 267776.9257957703 297404.1249767087 280786.92128705163 0.939715382060222 1.1012881764187352 1.072294893075369 1.0387258152412984 1.054407335863923 0.9613588727996053 1.0180352005863065 0.9536659491416231 1.0591808322605922 1.0 18.09911621266567 -6.739838539133696 24.89711819382917 0.9967764737691108 1.0462002186316193 0.1643166236544531 0.04758930105426759 363.3272597290988 418769.8430254863 0.01503865237358596 0.015025357504392161 1.8203775080082725e-07 6.739838539133696 0.049423744862508445 LSRLMSGSS(ph)RSLER ddPTM_A459_Selumetinib_30min_R1 4 LSRLMSGSSRSLER 14 2 F8WEJ8;F8WCI0;B5MC67;Q7Z6J6-2;Q7Z6J6 F8WEJ8 FRMD5 FERM domain-containing protein 5 1 LSRLMS(0.02)GS(0.02)S(0.959)RSLER;LSRLMSGSS(0.999)RSLER;LSRLMSGSS(1)RSLER;LSRLMS(0.002)GS(0.002)S(0.995)RS(0.001)LER 208.15 0.00020303 114309000.0 7984.6 8867.7 7681.9 8324.3 8177.8 7453.5 7767.4 7545.9 3888.3 6745.2 True False 8170.625644672959 7829.465561518112 6638.74017365625 6870.617271463745 7438.119433907853 7378.5245572365275 7181.4987644303865 7345.758219462384 6598.161109804177 7611.012123811883 1.0735268203174009 1.0287022848147587 0.8722545787157829 0.9027205790368233 0.9772838766918901 0.9694537910604567 0.9435668538698398 0.9651486687927322 0.8669229535400567 1.0 12.893872602899581 -5.070865813435204 5.687719650357559 0.9377057363868972 1.0637888136742686 0.5472055993018645 0.042310652608950686 0.14088676262892744 8.318788440933334 0.010866457777683717 0.030976622576807434 8.494428919471682e-06 5.070865813435204 0.12608307728737134 LSS(ph)DSFAR ddPTM_A459_Selumetinib_30min_R1 1 LSSDSFAR 8 0 A0A087WSV0;Q9HB09-3;Q9HB09 A0A087WSV0 BCL2L12 Bcl-2-like protein 12 1 LS(0.196)S(0.779)DS(0.025)FAR 143.04 0.0021769000000000003 13292000.0 4108.7 4058.5 3623.8 2921.4 3732.3 3177.6 3517.3 3835.1 1953.3 3463.0 True False 4204.424715861509 3583.3289332545396 3131.7078641085554 2411.2323314698183 3394.714123991086 3145.6362290299585 3251.987229205523 3733.380689839544 3314.607436612528 3907.5097824765094 1.0759857172249534 0.9170364586991488 0.8014587393108803 0.6170764670335956 0.8687666347541624 0.8050232511603108 0.8322403295800508 0.955437323940209 0.8482659343495718 1.0 11.932033769688097 -9.895324249280087 9.35793276321547 0.9999999994524768 0.8517915228307332 0.12417303843842686 0.11214144713280519 0.0 0.0 0.11480343104928675 0.02784392211330771 1.2725526237516224e-10 9.895324249280087 -0.14820847662174352 LSS(ph)EDEEEDEAEDDQSEASGKK ddPTM_A459_Selumetinib_30min_R1 1 LSSEDEEEDEAEDDQSEASGKK 22 1 Q8NEJ9-2;Q8NEJ9;G3V4G1 Q8NEJ9-2 NGDN Neuroguidin 1 LS(0.172)S(0.828)EDEEEDEAEDDQSEASGKK 183.1 6.7662e-17 8171500.0 968.76 960.4 1018.3 947.64 834.8 908.56 949.13 921.68 559.59 912.5 True False 991.330223121181 847.9559215221525 880.0204531215143 782.1524634059206 759.2924873959105 899.4207113064762 877.5363599510529 897.2340523614272 949.5833591634696 1029.6282635026894 0.9628040121478189 0.8235554049745039 0.854697257559515 0.7596454867556941 0.7374433223238022 0.8735392599332301 0.8522846458835196 0.8714155236076458 0.922258442996781 1.0 10.00790784614561 -8.416535520503833 1.0613739820413983 0.9990145677982732 0.8292415865725441 0.4427549517946978 0.05807908260577253 0.4845260808516414 1.1864784964159665 0.05763881636398788 0.01902379448190251 3.832343947669344e-09 8.416535520503833 -0.16977298122572915 LSS(ph)EDEEEDEAEDDQSEASGKK ddPTM_A459_Selumetinib_30min_R2 1 LSSEDEEEDEAEDDQSEASGKK 22 1 Q8NEJ9-2;Q8NEJ9;G3V4G1 Q8NEJ9-2 NGDN Neuroguidin 1 LS(0.18)S(0.82)EDEEEDEAEDDQSEASGKK 107.88 2.9251e-05 10353000.0 26098.0 23309.0 18397.0 26988.0 30253.0 18226.0 17762.0 17941.0 13548.0 30173.0 True False 24647.577638571587 25096.72534975212 17213.3570491391 23312.187843103227 26452.34767474848 20736.466060845003 18587.9681947353 17993.20533970756 16257.978562748222 29301.827091131123 0.8411618006588998 0.8564901182338976 0.5874499564687256 0.7955881990089008 0.9027542068444904 0.707685087225205 0.6343620872829933 0.6140642794644577 0.5548452153575459 1.0 14.838703005054708 -6.986530011719306 24.345663205587552 0.6689947080562713 0.7900150467751265 0.08793317641491116 0.1369744866734759 330.4316610492279 597218.8856183663 0.0472136771344684 0.04161455909713014 1.0315017955220205e-07 6.986530011719306 0.1210203387188552 LSS(ph)FSCGQASATPFTDIK ddPTM_A459_Selumetinib_30min_R1 1 LSSFSCGQASATPFTDIK 18 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 LS(0.154)S(0.846)FSCGQASATPFTDIK 204.9 4.4281000000000003e-11 11068000.0 1404.4 2478.5 1999.9 2202.3 1862.7 1898.1 1664.5 1967.5 1112.1 1696.5 True False 1437.1197875133023 2188.316067776611 1728.3245646643577 1817.7096472910166 1694.2191138863952 1879.0068373369086 1538.9454249033618 1915.3155086593047 1887.1524754296788 1914.2623003093836 0.7507433998366027 1.1431641669080224 0.9028671590016819 0.9495614300073913 0.8850506608277116 0.9815827418391007 0.8039365475957172 1.000550190195853 0.9858379779639795 1.0 10.902572812201845 LSS(ph)FSCGQASATPFTDIK ddPTM_A459_Selumetinib_30min_R2 1 LSSFSCGQASATPFTDIK 18 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 LS(0.087)S(0.904)FS(0.009)CGQASATPFTDIK 135.57 0.00035861 3635300.0 13338.0 15742.0 16299.0 16363.0 18833.0 18919.0 17736.0 12866.0 12667.0 19802.0 True False 12596.72735624446 16949.360781492054 15250.340085009411 14134.331172250575 16467.03017084381 21524.92052041733 18560.75914321727 12903.437929919042 15200.753945551505 19230.264808225173 0.6550470043894864 0.8813898794697029 0.7930384857979976 0.7350045001047014 0.8563080298197728 1.1193252269313883 0.9651847922176536 0.6709963725720501 0.7904599389109731 1.0 14.231091008835831 -4.758089300566768 24.750631522683868 0.86171810467679 0.6550466778926237 0.20298051236198145 0.12602803512024993 156.8066933857815 1158286.437341984 0.03386921847089742 0.23783673667255512 1.7454632101137673e-05 4.758089300566768 -0.20667142678416628 LSS(ph)GFDDIDLPSAVK ddPTM_A459_Selumetinib_30min_R1 1 LSSGFDDIDLPSAVK 15 0 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 LS(0.003)S(0.997)GFDDIDLPSAVK 193.98 3.1824e-05 85976000.0 5700.5 3739.9 4722.0 4064.6 4882.9 2850.3 4410.3 5799.6 2591.6 4651.2 True False 5833.310558757885 3302.030769367658 4080.7783360893554 3354.7939119915864 4441.242557146014 2821.628569865336 4077.6275202471 5645.775768244221 4397.755917025046 5248.226826524615 1.1114821732315852 0.6291707425218641 0.7775537283306891 0.639224260475254 0.8462367774769013 0.5376346455920663 0.776953370162797 1.075749192033848 0.8379508093664556 1.0 12.357614358739744 -7.649215580974849 6.958850566802658 0.9661656401056298 0.743414512536359 0.2762544998093083 0.15597860160535826 0.2663341428764657 15.185988880801398 0.07068994511239489 0.0403985902262143 2.2427683517013326e-08 7.649215580974849 -0.22275112756927073 LSS(ph)GFDDIDLPSAVK ddPTM_A459_Selumetinib_30min_R2 3 LSSGFDDIDLPSAVK 15 0 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 LS(0.092)S(0.908)GFDDIDLPSAVK;LS(0.291)S(0.709)GFDDIDLPSAVK;LS(0.417)S(0.582)GFDDIDLPSAVK 164.66 9.2752e-05 29700300.0 67208.0 41607.8 53410.0 64481.0 55627.0 53127.0 57092.0 58089.0 46543.0 52202.0 True False 63472.84841494056 44798.9844698364 49973.658748411086 55698.57656407071 48638.63894831037 60444.76201111118 59746.89112565178 58258.029372848396 55852.90052007608 50694.79262291539 1.2520585474542243 0.8836999256129924 0.9857749911343294 1.098704101195859 0.9594405348513926 1.192326842339001 1.1785607166808807 1.149191590666735 1.10174827887212 1.0 15.629549940526912 -6.765764980522122 24.99957225365443 1.1370771598193026 1.0281785178107494 0.14648044470176347 0.10365888188464388 176.04768563667932 1017450.1757758779 0.03454832794464243 0.031538353230772254 1.7148850705348128e-07 6.765764980522122 -0.10889864200855315 LSS(ph)GLVSPAPSFYSK ddPTM_A459_Selumetinib_30min_R2 1 LSSGLVSPAPSFYSK 15 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 LS(0.199)S(0.751)GLVS(0.05)PAPSFYSK 166.64 7.8182e-05 14788000.0 41816.0 36142.0 48975.0 42092.0 44493.0 36511.0 40527.0 43424.0 31425.0 34284.0 True False 39492.03412271096 38913.97518515345 45824.0018199482 36358.99698724996 38903.39156753327 41540.05883614133 42411.58580272703 43550.35665076983 37710.87808786264 33294.131839470385 1.1861559962916026 1.1687938094550556 1.3763386905804098 1.092054214314913 1.168475927082534 1.2476690798375272 1.2738456736825872 1.3080490237964586 1.1326583996749895 1.0 15.022980301226662 -8.545420316205728 6.705944700994191 1.000012709643873 1.2261822094082304 0.46417840583599845 0.07629328468413574 0.1845620798109367 46.505022583354936 0.07450897103725301 0.0192854779389022 2.8482603473879083e-09 8.545420316205728 0.22616949976435752 LSS(ph)PGPSR ddPTM_A459_Selumetinib_30min_R1 1 LSSPGPSR 8 0 Q86VQ6;H0YBI6;H0YBQ0 Q86VQ6 TXNRD3 Thioredoxin reductase 3 1 LS(0.135)S(0.864)PGPSR 101.65 0.016863999999999997 22708000.0 6176.8 7698.4 7806.2 7890.5 7459.5 5867.3 6854.4 6154.3 3586.7 5356.6 True False 6320.707422039421 6797.067749110933 6746.160916387274 6512.572298029231 6784.789542081694 5808.280289082162 6337.367089490899 5991.067972016247 6086.367937796626 6044.1717877024785 1.0457524445118491 1.1245656126022596 1.116143146379967 1.0774962272382405 1.1225341999521063 0.9609720724516363 1.0485087638284798 0.9912140459352468 1.0069812956309416 1.0 12.56132895008614 -6.754316246024593 24.999784797216346 1.0039219567094877 1.098760001250153 0.7219625142340027 0.029688695612116303 85.56766326945231 300313.46109718666 0.009435987695516491 0.009246182353895847 1.76069347176669e-07 6.754316246024593 0.09483804454066536 LSS(ph)PGPSR ddPTM_A459_Selumetinib_30min_R2 1 LSSPGPSR 8 0 Q86VQ6;H0YBI6;H0YBQ0 Q86VQ6 TXNRD3 Thioredoxin reductase 3 1 LS(0.021)S(0.979)PGPSR 111.46 0.011591 20012000.0 51902.0 46980.0 53255.0 55914.0 60027.0 40257.0 48258.0 51130.0 35122.0 52299.0 True False 49017.49462016794 50583.21493549079 49828.63127965989 48298.41674297002 52485.87161181127 45802.03633333903 50502.09262141287 51278.77983497283 42147.381390673385 50788.99198087917 0.9651204465452248 0.9959483928039791 0.9810911643692233 0.950962302247566 1.0334103821468033 0.9018103046932373 0.9943511507459273 1.009643582890522 0.8298526855295899 1.0 15.632228220335856 -8.21801914870604 24.999886824156622 0.9149256816850361 0.9784862288296501 0.20282655878902067 0.05083436687758953 592.2270557368221 340985.04728604754 0.031558097674550194 0.011927635188893386 6.053141849399561e-09 8.21801914870604 0.06356054714461401 LSS(ph)PIDMTSK ddPTM_A459_Selumetinib_30min_R2 1 LSSPIDMTSK 10 0 Q16649 Q16649 NFIL3 Nuclear factor interleukin-3-regulated protein 1 LS(0.04)S(0.96)PIDMTSK 93.839 0.024656 3768300.0 33368.0 23911.0 28573.0 27782.0 38749.0 28562.0 33278.0 41836.0 42215.0 52398.0 True False 31513.540142687434 25744.896814017036 26734.644287930187 23998.043673376844 33881.00419954477 32496.156239978856 34825.49293910602 41957.73583367736 50659.17958565221 50885.13359364623 0.6193074070384749 0.5059414213119344 0.5253920428199172 0.47161207957157375 0.6658330598109173 0.6386178819826561 0.6843942519088622 0.8245578397954018 0.9955595280578721 1.0 15.63495660513421 -7.768461855734527 0.8908646168619153 1.0266709262058427 0.5409578883255133 0.9129583453282055 0.05313741342676644 0.15693907239661095 0.22873276478554513 0.0489020855476495 0.02080031848857446 1.7042689993992107e-08 7.768461855734527 -0.4857130378803294 LSS(ph)PISK ddPTM_A459_Selumetinib_30min_R1 1 LSSPISK 7 0 Q99728-3;Q99728-2;Q99728;A0A494C142 Q99728-3 BARD1 BRCA1-associated RING domain protein 1 1 LS(0.093)S(0.907)PISK 88.177 0.03262 36341000.0 11933.0 17446.0 13618.0 14715.0 13846.0 13250.0 13891.0 13094.0 6407.0 11325.0 True False 12211.015682423982 15403.41420957464 11768.750398319533 12145.301484760166 12593.631744709852 13116.717030037427 12843.190686291742 12746.704584693747 10872.211051234563 12778.674064841607 0.9555776773445187 1.205400038487136 0.9209680392975426 0.9504351878084081 0.9855194428472929 1.0264536808342182 1.0050487727539466 0.9974982161697183 0.8508090116444584 1.0 13.641450527311829 -5.290584891396975 24.999591233841183 0.9705411553054465 1.0804889812132308 0.27298883935222396 0.07385052231722769 780.0731875470461 669107.1909664067 0.018479530222273367 0.038478711334629837 5.121711465567424e-06 5.290584891396975 0.10994782590778429 LSS(ph)PISK ddPTM_A459_Selumetinib_30min_R2 1 LSSPISK 7 0 Q99728-3;Q99728-2;Q99728;A0A494C142 Q99728-3 BARD1 BRCA1-associated RING domain protein 1 1 LS(0.088)S(0.912)PIS(0.001)K 96.034 0.023406 40658000.0 234740.0 220580.0 246760.0 239360.0 238740.0 170060.0 192460.0 212700.0 178500.0 187470.0 True False 221694.09053867342 237497.77672351166 230883.73025197446 206758.755080969 208747.34683732042 193484.22134902352 201409.7713522553 213318.92178561952 214204.9877067141 182057.25399444407 1.2177163264554072 1.3045224593509441 1.2681929732886141 1.135679850951057 1.1466027431331622 1.0627657899032585 1.1062990731388371 1.1717133874387091 1.1765803504498158 1.0 17.474032699939457 -5.789889879213052 4.655074092363828 1.118878100934767 1.268916662105865 0.6231385848659459 0.05317691690549922 0.12599999963221437 6.439965281480894 0.014950946148684457 0.02388694159545857 1.6222213796939678e-06 5.789889879213052 0.15003856117109793 LSS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 LSSPVK 6 0 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 LS(0.069)S(0.931)PVK 92.47 0.043433 225560000.0 204700.0 167450.0 168690.0 166560.0 174600.0 150740.0 254710.0 375470.0 216670.0 284150.0 True False 193323.59347902553 180292.87656338746 157836.6690557848 143874.24066797347 152665.18705619566 171503.0667185214 266554.5196982897 376562.5555375953 260010.05426562246 275945.851189636 0.7005852512207887 0.6533632442239049 0.5719842076818035 0.5213857720553297 0.5532432772518142 0.6215098577461879 0.9659667595984534 1.3646248128543643 0.9422502753518041 1.0 18.074025669395184 -7.349148121886581 3.5004580459660346 1.121880602653146 0.5961511884239896 0.7992366947537649 0.11504288385189469 0.09783620329441883 2.281216450590042 0.0502412990944125 0.032662942227078835 4.4756063165964477e-08 7.349148121886581 -0.5257294142291564 LSS(ph)PVLHR ddPTM_A459_Selumetinib_30min_R1 4 LSSPVLHR 8 0 Q16643-3;Q16643;Q16643-2;D6R9W4;D6RCR4 Q16643-3 DBN1 Drebrin 1 LS(0.079)S(0.921)PVLHR;LS(0.054)S(0.946)PVLHR;LS(0.131)S(0.869)PVLHR;LS(0.069)S(0.931)PVLHR 164.46 0.00030101 1094779000.0 28066.600000000002 32511.0 33355.3 35159.899999999994 34334.1 27829.200000000004 33026.4 29415.4 14500.7 23785.199999999997 True False 28720.49717190317 28704.597006046155 28825.833467547905 29019.8834980645 31228.586717177684 27549.263514891903 30535.192058292825 28635.20803731481 24606.62881077525 26838.262107467584 1.0701325241142148 1.0695400801700672 1.0740573794279806 1.081287729505775 1.1635845343536055 1.0264920807680198 1.1377484852045092 1.0669546307675128 0.9168488150329452 1.0 14.712003633423093 -8.154507005242142 5.525911774009585 0.9599878402177838 1.088607202548241 0.6159365235777443 0.04058064372345762 0.13279582480671423 5.566986765493757 0.027106018956134667 0.009844983709321428 7.0063688138497225e-09 8.154507005242142 0.12861936233045712 LSS(ph)PVLHR ddPTM_A459_Selumetinib_30min_R2 8 LSSPVLHR 8 0 Q16643-3;Q16643;Q16643-2;D6R9W4;D6RCR4 Q16643-3 DBN1 Drebrin 1 LS(0.137)S(0.863)PVLHR;LS(0.134)S(0.866)PVLHR;LS(0.134)S(0.866)PVLHR;LS(0.049)S(0.951)PVLHR;LS(0.137)S(0.863)PVLHR;LS(0.405)S(0.595)PVLHR;LS(0.141)S(0.859)PVLHR;LS(0.101)S(0.899)PVLHR 177.3 0.00021473 1587661400.0 1071787.0 926439.0 1208131.0 1185369.0 1131742.0 746427.0 811089.3 768952.6 722508.0 990769.0 True False 1012221.3692433047 997493.8923291004 1130401.1667735735 1023919.6973244217 989562.4520581482 849240.5438603291 848806.5595929571 771190.1247590443 867029.788560239 962162.9246429907 1.0520269938886786 1.0367203586640166 1.1748542142101426 1.064185358944636 1.0284770143531814 0.8826369444399852 0.8821858937330241 0.8015171911193661 0.9011257515269041 1.0 19.875921683060618 -6.655910934362175 2.736493742266041 0.8779321959113962 1.0838937159550983 0.7049195617194328 0.057815471538593115 0.1394309582233699 2.1164382272480893 0.020682304721867974 0.02039908224387305 2.2084575997367725e-07 6.655910934362175 0.20596152004370216 LSS(ph)SLGR ddPTM_A459_Selumetinib_30min_R2 4 LSSSLGR 7 0 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 LS(0.069)S(0.465)S(0.465)LGR;LS(0.005)S(0.497)S(0.497)LGR;LS(0.253)S(0.48)S(0.268)LGR;LS(0.086)S(0.575)S(0.339)LGR 104.75 0.017843 156713000.0 359451.0 317032.0 375369.0 399144.0 411243.0 293717.0 302016.0 316283.0 252682.0 340071.0 True False 339474.1524163611 341347.33498144936 351218.16721086483 344779.89863819536 359578.97778093343 334173.8506525408 316060.3424333504 317203.33116653044 303225.4605249739 330252.26661942893 1.0279237623145798 1.0335957372089923 1.0634845017296921 1.0439894998071506 1.0888009383302721 1.0118745105771854 0.9570270195830849 0.9604879760963589 0.9181631473082371 1.0 18.333208937587607 -7.10334801160054 3.355089216159053 0.9555023705400759 1.0509375798517548 0.7572676701468535 0.02458250868003908 0.11809408437476071 2.4916280958377572 0.009811979809227461 0.007503349606783234 7.882282364459957e-08 7.10334801160054 0.09543520931167893 LSS(ph)SPGLFGAFSVR ddPTM_A459_Selumetinib_30min_R1 2 LSSSPGLFGAFSVR 14 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 LSS(0.648)S(0.351)PGLFGAFSVR;LSS(0.62)S(0.38)PGLFGAFSVR 214.48 1.16e-06 55122000.0 5793.7 5690.6 6309.2 6725.700000000001 6924.6 5349.4 6088.4 5250.9 3445.6 4786.1 True False 5928.681937422258 5024.341906511834 5452.445293954881 5551.182752025245 6298.271152637428 5295.589892866582 5629.147086201037 5111.629074673007 5846.9315433328875 5400.442555561894 1.0978140914241061 0.9303574391949202 1.0096293475688265 1.027912563630198 1.166250929963298 0.9805844314393597 1.0423492201400424 0.9465204049635824 1.0826763701636186 1.0 12.398861922781334 -5.782473376042616 5.267872848289844 1.0366766284486588 1.004077899725087 0.01889212022614095 0.06770602883757718 0.6674418241702426 50.95596277215107 0.01891436239552185 0.030018759852777497 1.6501621596407088e-06 5.782473376042616 -0.032598728723571835 LSS(ph)SPGLFGAFSVR ddPTM_A459_Selumetinib_30min_R2 2 LSSSPGLFGAFSVR 14 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 LS(0.001)S(0.5)S(0.5)PGLFGAFSVR;LS(0.004)S(0.498)S(0.498)PGLFGAFSVR 201.3 6.0184e-05 24574100.0 78835.0 84616.0 93711.0 104453.0 108305.0 77928.0 73650.0 67091.0 60080.0 83760.0 True False 74453.66630150942 91105.77511667724 87681.73628482228 90226.32120852475 94698.75764101511 88661.87464004869 77074.87093470644 67286.22370248707 72097.6787754585 81341.63116538437 0.9153205466230412 1.120038703569152 1.0779441600642008 1.1092268487347636 1.1642102117238458 1.0899938121449857 0.9475451848020761 0.8272052421186422 0.8863564418676212 1.0 16.311706301387304 -7.368111235210887 3.759327844433566 0.8920639662535389 1.0865913025265137 0.5482331992366536 0.07309736323747859 0.16762932985874876 4.277409209139975 0.03252994479041231 0.02109549493634281 4.2843877094685783e-08 7.368111235210887 0.1945273362729748 LSS(ph)SVSAMR ddPTM_A459_Selumetinib_30min_R2 2 LSSSVSAMR 9 0 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4M5;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 LS(0.025)S(0.487)S(0.487)VSAMR;LS(0.002)S(0.499)S(0.499)VSAMR 131.12 0.0036806 11098300.0 41860.0 26205.0 40747.0 45153.0 37672.0 38494.0 36701.0 39169.0 25892.0 39196.0 True False 39533.58877885691 28214.83923764445 38125.38238197916 39003.08350673041 32939.30656804695 43796.19908625961 38407.66922165185 39282.97530522297 31071.123482925654 38064.30963656166 1.0385999156775452 0.7412413230934691 1.0016044621851972 1.0246628371598532 0.865359358479156 1.1505843532806999 1.0090205126105949 1.032015966670541 0.8162797060972075 1.0 15.216151292167964 LSS(ph)TDDGYIDLQFK ddPTM_A459_Selumetinib_30min_R1 1 LSSTDDGYIDLQFK 14 0 Q96A57-2;Q5JWB9;A0A087WTT2;Q96A57 Q96A57-2 TMEM230 Transmembrane protein 230 1 LSS(0.995)T(0.005)DDGYIDLQFK 191.01 0.00010454 15061000.0 2548.9 2386.9 3239.4 2824.2 3156.8 2640.5 3049.5 3236.6 1524.0 2125.0 True False 2608.284410703969 2107.4406383602964 2799.507272750498 2331.0064867998403 2871.2679973783083 2613.9389673821756 2819.473759833463 3150.7548540415264 2586.116691443962 2397.7644492528393 1.0877984330432162 0.8789189609584003 1.167548911496642 0.9721582482909022 1.1974770909098331 1.0901566949984174 1.1758760376616775 1.3140385224342301 1.07855327167346 1.0 11.227474223403295 -6.118764887530607 1.2125132446821096 1.1613196818714469 1.0083005998141814 0.1632875301401795 0.10877859592329502 0.6760018003069409 2.0288570078857053 0.04070738089495296 0.06868844896203354 7.60738003528078e-07 6.118764887530607 -0.15301908205726544 LSS(ph)TDDGYIDLQFK ddPTM_A459_Selumetinib_30min_R2 4 LSSTDDGYIDLQFK 14 0 Q96A57-2;Q5JWB9;A0A087WTT2;Q96A57 Q96A57-2 TMEM230 Transmembrane protein 230 1 LS(0.007)S(0.94)T(0.053)DDGYIDLQFK;LS(0.006)S(0.944)T(0.05)DDGYIDLQFK;LS(0.196)S(0.781)T(0.023)DDGYIDLQFK;LS(0.001)S(0.948)T(0.051)DDGYIDLQFK 158.31 4.0706e-05 0.0 43476.3 25359.199999999997 39349.5 46407.1 38597.899999999994 23098.6 46431.1 40891.0 30356.600000000002 28365.100000000002 True False 41060.06129541843 27304.1690973201 36817.796010496204 40086.37292328723 33748.88673239592 26280.222481786142 48590.2381514792 41009.98604013052 36428.76823427239 27546.125861619446 1.4905929603925978 0.9912163051343467 1.3365870828970239 1.4552453991049374 1.2251772500400466 0.9540442316210749 1.7639590552797453 1.4887750911379714 1.3224643064972452 1.0 14.749561809298743 -7.254127413278963 24.998622743497307 1.4345308723391148 1.2439461898719548 0.07782863354149372 0.23982776396135388 1222.9055510844305 4180956.3625743724 0.09097468771790979 0.06899297621168968 5.5702230579991085e-08 7.254127413278963 -0.19058468246715998 LSS(ph)TPPLSALGR ddPTM_A459_Selumetinib_30min_R2 1 LSSTPPLSALGR 12 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 1 LS(0.006)S(0.894)T(0.065)PPLS(0.035)ALGR 125.36 0.002888 7078600.0 52163.0 36102.0 57092.0 57634.0 69086.0 38670.0 44024.0 51225.0 37670.0 40563.0 True False 49263.98928503371 38870.90731377371 53418.762877069574 49784.149775804515 60406.79904332366 43996.44148869066 46071.20323190106 51374.056269244735 45205.05258774178 39391.84079466915 1.2506140431929382 0.9867755994544448 1.356086991606106 1.2638188206361187 1.5334850523537462 1.1168922447169476 1.1695620794176194 1.3041801356030338 1.1475740070989353 1.0 15.265609215726805 -8.561876798900165 4.4514037284313615 1.0001027848464767 1.2452228189553798 0.23896111092907368 0.13722835215865814 0.3321299631357524 22.553221230174238 0.1348120516453748 0.03518201709708719 2.7423520147986056e-09 8.561876798900165 0.24512003410890304 LSSERPS(ph)SDGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R2 1 LSSERPSSDGEGVVENGITTCNGK 24 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 LS(0.008)S(0.094)ERPS(0.821)S(0.077)DGEGVVENGITTCNGK 86.073 5.4925e-05 48627000.0 74242.0 73332.0 83749.0 96052.0 95594.0 71714.0 92474.0 92313.0 89388.0 92024.0 True False 70115.92685427365 78956.32860045577 78360.68051901672 82969.55190105784 83584.62709879695 81591.95254512453 96774.22423375465 92581.61554676016 107268.09770939883 89367.02801293385 0.7845838494721562 0.8835062590313357 0.8768410705979367 0.9284134623907363 0.935296036550527 0.9129983883241137 1.0828851130614836 1.0359706214394986 1.2003095559345915 1.0 16.447455026435016 -7.029033035497021 0.9048091179351098 1.1023298342786125 0.8594938819638042 0.701024922243757 0.06171884481001329 0.31448453709333773 0.5306094190260023 0.04163861498997263 0.029562849341219465 9.353345233100829e-08 7.029033035497021 -0.24283595231480837 LSSERPSS(ph)DGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R1 2 LSSERPSSDGEGVVENGITTCNGK 24 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 LS(0.004)S(0.016)ERPS(0.153)S(0.826)DGEGVVENGITTCNGK;LS(0.011)S(0.037)ERPS(0.316)S(0.634)DGEGVVENGIT(0.001)TCNGK 141.43 1.8555e-08 157330000.0 8536.4 9520.4 9382.9 9344.0 9367.7 7261.7 8253.9 8279.8 5096.4 6391.8 True False 8735.281511057072 8405.747142086111 8108.753716580432 7712.245808603401 8520.393189001768 7188.653891096061 7631.3016777469875 8060.1928074192165 8648.21857367127 7212.249791404375 1.2111729021737239 1.165481976526126 1.1243029499955088 1.06932594289717 1.1813779937511941 0.996728357864638 1.0581027971108325 1.1175698347311025 1.1991013655653324 1.0 12.81623364906679 -4.961119358829022 1.1242665678925348 1.0903790466108778 1.2492629737757677 0.2930038015303258 0.0628289350594838 1.7071455187341695 2.2250522427478954 0.020238466636941368 0.2991033912021565 1.0936557513322919e-05 4.961119358829022 0.15888392716488986 LSSERPSS(ph)DGEGVVENGITTCNGK ddPTM_A459_Selumetinib_30min_R2 3 LSSERPSSDGEGVVENGITTCNGK 24 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 LSS(0.005)ERPS(0.181)S(0.814)DGEGVVENGITTCNGK;LS(0.002)S(0.006)ERPS(0.185)S(0.807)DGEGVVENGITTCNGK;LS(0.001)S(0.002)ERPS(0.029)S(0.968)DGEGVVENGITTCNGK 135.34 4.7987000000000005e-08 215066000.0 184219.0 165455.0 219315.0 226233.0 244287.0 195576.0 207544.0 202238.0 194481.0 208321.0 True False 173980.84546708642 178144.86647832295 205204.51167211693 195419.67512630686 213597.4831065112 222514.81873783734 217195.20724063416 202826.47909769652 233382.6342531618 202306.2314470392 0.8599875753833714 0.8805703373746975 1.014326203421156 0.9659597419640772 1.0558126735825628 1.0998910767416892 1.0735962292762726 1.0025715849034216 1.1536107048400928 1.0 17.626181232984926 -5.24414571587247 0.840328117150166 1.067786190612685 0.7997406769762536 0.6958202284054718 0.048148136520416183 0.735193961878221 0.6316829590086172 0.01844947282929981 0.16106798012369578 5.69973001031767e-06 5.24414571587247 -0.2680455136364315 LSSESHHGGS(ph)PIHWVLPAGMSAK ddPTM_A459_Selumetinib_30min_R2 2 LSSESHHGGSPIHWVLPAGMSAK 23 0 J3QR07;Q96MU7;Q96MU7-2 J3QR07 YTHDC1 YTH domain-containing protein 1 1 LS(0.011)S(0.011)ES(0.011)HHGGS(0.967)PIHWVLPAGMSAK;LS(0.012)S(0.012)ES(0.013)HHGGS(0.962)PIHWVLPAGMSAK 76.678 0.00043053 10460900.0 24113.8 24500.0 58311.0 106624.0 131995.0 57881.0 38373.0 45836.0 85924.0 99431.0 True False 22773.65153118966 26379.071220083526 54559.333744216456 92101.62726334055 115412.60804972808 65853.58235859594 40157.42053465697 45969.37517144174 103111.20091715227 96560.16867723664 0.23584933459792498 0.27318791569491324 0.5650293955739374 0.9538262880546607 1.1952403318132954 0.6819953119460577 0.41587976786668346 0.4760697480251884 1.0678440430423564 1.0 16.55914057583294 -5.427886787404254 3.1723125861571773 0.7966308477487725 0.2519413490422292 0.47696158974975156 0.23769327141474306 0.2513069091936947 4.772076650137271 0.07179495873807915 0.16718532879111733 3.7334746994042585e-06 5.427886787404254 -0.5446894987065433 LSSGDPSTSPSLSQT(ph)TPSKDTDDQSR ddPTM_A459_Selumetinib_30min_R2 1 LSSGDPSTSPSLSQTTPSKDTDDQSR 26 1 Q99504-2;Q99504-4;Q99504-5;Q99504-3;Q99504 Q99504-2 EYA3 Eyes absent homolog 3 1 LSSGDPS(0.002)T(0.002)S(0.003)PS(0.002)LS(0.094)QT(0.643)T(0.245)PS(0.007)KDT(0.002)DDQSR 100.57 2.5313e-06 9987800.0 34455.0 31570.0 34605.0 43859.0 33008.0 31811.0 39000.0 38756.0 22656.0 38704.0 True False 32540.129034293223 33991.317486450505 32378.551975075192 37885.32853900492 28861.23994473597 36192.676498493354 40813.57727703393 38868.773543598785 27187.83306153111 37586.51495493118 0.8657394566458496 0.904348741222974 0.8614406526888514 1.0079500210230194 0.7678615583100105 0.9629165284914247 1.0858569177262702 1.034114857155688 0.723340088702855 1.0 15.197927533549057 -6.963614278558605 24.999971558025393 0.9723447760503326 0.8863269029062264 0.12219797104362062 0.10472004141735398 356.67202209087327 245061.85944488368 0.03664650156605759 0.032319094590113506 1.0873909681573811e-07 6.963614278558605 -0.08601787314410625 LSSGDPSTSPSLSQTTPS(ph)KDTDDQSR ddPTM_A459_Selumetinib_30min_R2 1 LSSGDPSTSPSLSQTTPSKDTDDQSR 26 1 Q99504-2;Q99504-4;Q99504-5;Q99504-3;Q99504 Q99504-2 EYA3 Eyes absent homolog 3 1 LSSGDPS(0.001)T(0.002)S(0.035)PS(0.035)LS(0.001)QT(0.002)T(0.057)PS(0.833)KDT(0.035)DDQSR 121.65 4.2376e-09 13076000.0 27631.0 24374.0 26329.0 28148.0 29983.0 21461.0 24927.0 22618.0 20211.0 23696.0 True False 26095.37963565684 26243.40742523738 24635.020804847703 24314.193841991633 26216.2674885791 24417.05794643884 26086.15489191346 22683.814635388524 24253.764742523195 23011.83491039813 1.1339982116708727 1.1404308925134445 1.0705370041445987 1.0565951796831734 1.1392515021361036 1.061065231934449 1.133597342127905 0.9857455836839248 1.0539691787708718 1.0 14.49008840485798 -7.762068223461612 24.999999997396966 1.0148930277081125 1.1028579215299668 0.5918944015389607 0.03490085269148378 12.174008298942839 483906.11104682 0.017638551771845767 0.00927081591302345 1.7295446431423725e-08 7.762068223461612 0.08796489382185424 LSSGLVS(ph)PAPSFYSK ddPTM_A459_Selumetinib_30min_R1 2 LSSGLVSPAPSFYSK 15 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 LS(0.002)S(0.124)GLVS(0.87)PAPS(0.003)FYSK;LSSGLVS(0.996)PAPS(0.003)FYSK 150.12 0.00027193 36236000.0 8802.5 6434.1 7817.9 7257.200000000001 7980.5 5304.8 7416.9 8541.3 5154.7 7369.4 True False 9007.581123316604 5680.792580868059 6756.272120650772 5989.866254515903 7258.665184071716 5251.438528373021 6857.437261619552 8314.756977947502 8747.14941560774 8315.334274034762 1.0832494312878598 0.6831706812565249 0.8125075791297681 0.7203398032018626 0.8729252420720389 0.6315366713243292 0.8246736734363646 0.9999305745183255 1.0519299798832324 1.0 13.02155854526409 -7.753416361101027 4.262669398912986 1.0248922130812828 0.7905964446974223 0.41229679055320656 0.11673087625819983 0.18402909218805932 7.763708798501124 0.0603717289455257 0.030339011136160665 1.7643455194444854e-08 7.753416361101027 -0.23429576838386046 LSSGLVS(ph)PAPSFYSK ddPTM_A459_Selumetinib_30min_R2 1 LSSGLVSPAPSFYSK 15 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 LS(0.008)S(0.008)GLVS(0.956)PAPS(0.027)FYS(0.001)K 152.94 0.0002172 15878000.0 46703.0 44953.0 53421.0 48049.0 43032.0 45274.0 41428.0 39839.0 38695.0 36470.0 True False 44107.43422692194 48400.75055332306 49983.951020387016 41504.64331085177 37625.93544903899 51510.08254354746 43354.484088024656 39954.924894298485 46435.08122863463 35417.01633956027 1.245374082447894 1.3665959348263945 1.4112976243161313 1.1718842409797154 1.062368864963122 1.454387971298742 1.2241145237183164 1.1281279177000982 1.3110952312707198 1.0 15.112155058792608 -14.522878735276189 0.15232259758447683 0.05604838489634976 1.341257749597154 0.3201292820602667 0.11745437879410288 168.12091445587254 1.5041360377792514 47.99712964998914 0.5879190485184206 3.0000000691062125e-15 14.522878735276189 1.2852093647008043 LSSLS(ph)LSPANHENQPSEGER ddPTM_A459_Selumetinib_30min_R1 1 LSSLSLSPANHENQPSEGER 20 0 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;G8JLP4 Q9Y4F3-3 KIAA0430 Meiosis arrest female protein 1 1 LS(0.044)S(0.044)LS(0.485)LS(0.427)PANHENQPSEGER 90.378 0.0011236 4756600.0 714.87 947.4 1131.3 1044.4 1398.3 723.36 1088.7 1014.6 483.73 707.08 True False 731.5250801051227 836.4779675656886 977.675673786084 862.0151458160732 1271.8240118899153 716.0836551583307 1006.578482482601 987.6895121147292 820.854479758654 797.8406055424466 0.9168812354539959 1.0484274199067276 1.225402250768333 1.080435289740605 1.5940828319025082 0.8975272130596438 1.261628545213282 1.2379534273555874 1.028845202984574 1.0 9.639956740028536 -4.966767506790498 2.730788649827414 1.1803472937574844 0.9091598148966495 0.15337912973796008 0.18151171043160086 0.5445991580195789 7.163590060751282 0.04532002807508054 0.2785603690429065 1.0795244752352682e-05 4.966767506790498 -0.27118747886083483 LSSLS(ph)LSPANHENQPSEGER ddPTM_A459_Selumetinib_30min_R2 1 LSSLSLSPANHENQPSEGER 20 0 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;G8JLP4 Q9Y4F3-3 KIAA0430 Meiosis arrest female protein 1 1 LS(0.063)S(0.049)LS(0.821)LS(0.064)PANHENQPS(0.003)EGER 97.713 0.0006089 6683300.0 11369.0 9626.9 15063.0 14196.0 13744.0 9731.8 9590.4 8891.2 6119.3 12510.0 True False 10737.156493712942 10365.252274637642 14093.862979354366 12262.480310534078 12017.355847081042 11072.267113515381 10036.372603017076 8917.071919982602 7343.330987527689 12148.803795116508 0.883803597028128 0.8531911823947798 1.1601029382843207 1.009357013030638 0.9891801735996177 0.9113874337131146 0.8261202314462786 0.73398764770298 0.604448891542681 1.0 13.568526648622315 -7.2461596180836905 2.052250291539863 0.7554275903278187 0.982850682375787 0.34983077016892994 0.11971680612193492 0.34129662544909756 2.809421941393399 0.060246586675695483 0.03903256747485989 5.673360516723039e-08 7.2461596180836905 0.2274230920479683 LSSLSLS(ph)PANHENQPSEGER ddPTM_A459_Selumetinib_30min_R1 1 LSSLSLSPANHENQPSEGER 20 0 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;G8JLP4 Q9Y4F3-3 KIAA0430 Meiosis arrest female protein 1 1 LSSLS(0.022)LS(0.977)PANHENQPSEGER 112.61 0.0002137 6693400.0 1737.0 1990.3 1826.2 2209.5 2054.9 1392.2 1846.8 1583.2 691.73 1684.2 True False 1777.4687203863596 1757.2747507346323 1578.2120705985549 1823.6523024517574 1869.0346578220624 1378.1957320164606 1707.4943891327896 1541.208393041632 1173.8152880397188 1900.3834754972384 0.9353210777215804 0.9246948173314539 0.8304703187263892 0.9596233212744579 0.9835039516606123 0.7252198042060187 0.8984999139113335 0.8109986289153416 0.6176728555969937 1.0 10.892074851837187 -6.755980288362142 24.999900970236276 0.8041670086405339 0.9230904927647854 0.24728225163822237 0.10100682467967534 193.167797031795 884611.210835702 0.03295689495167735 0.0320576036359117 1.753960108291577e-07 6.755980288362142 0.11892348412425147 LSSPAAFLPACNS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 LSSPAAFLPACNSPSK 16 0 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 LSSPAAFLPACNS(0.993)PS(0.007)K;LSSPAAFLPACNS(0.841)PS(0.159)K 231.38 2.3279e-15 222150000.0 9773.5 12860.199999999999 10232.7 11146.8 9532.6 9471.0 10932.4 10697.4 5761.9 9879.6 True False 10001.203534079508 11354.521805455215 8843.155544197698 9200.220631350636 8670.378013117224 9375.730338979967 10107.760266274268 10413.670201947672 9777.52346747439 11147.742895453344 0.8971505378150175 1.0185489486025199 0.7932687026540967 0.8252989612007455 0.7777698225040224 0.8410429292196808 0.9067091303654629 0.9341505540278412 0.877085483507356 1.0 13.444464014074406 -8.747315700714301 0.7764831473638173 0.9974761181700698 0.8634830207330639 0.251613295944088 0.06674286335213875 1.5051403655204814 1.851554965370581 0.07248112197442716 0.025980487252086137 1.789304685920197e-09 8.747315700714301 -0.13399309743700583 LSSPAAFLPACNS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 LSSPAAFLPACNSPSK 16 0 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 LSSPAAFLPACNS(0.949)PS(0.051)K;LSSPAAFLPACNS(0.863)PS(0.137)K 120.99 0.0013712 67620000.0 124378.0 93589.0 124340.0 132204.0 124004.0 85723.0 122038.0 114545.0 77041.0 109709.0 True False 117465.56868458333 100766.97536393462 116340.09977115582 114197.58713537936 108425.50891017448 97530.56513408394 127713.00881370949 114878.30698605435 92451.3527053944 106541.41611178554 1.1025343286345652 0.9458009761969725 1.0919706534507603 1.071860984235096 1.0176841351199248 0.9154239608731386 1.1987170198649346 1.0782502352467473 0.8677503648758756 1.0 16.70105483638124 -8.249587375135373 24.93784864914741 0.9338751775027795 1.0502728223597524 0.2529515635778128 0.08164559519786443 893.8958788880265 1880859.5987022852 0.055779836676574 0.020701894349395407 5.6287586174774994e-09 8.249587375135373 0.1163976448569729 LSSS(ph)KENLDASK ddPTM_A459_Selumetinib_30min_R1 2 LSSSKENLDASK 12 1 K7EQL6;Q8NFA0;K7EN13 K7EQL6 USP32 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 32 1 LS(0.006)S(0.291)S(0.703)KENLDASK;LSS(0.264)S(0.736)KENLDASK 159.18 0.0020897 66817000.0 10088.8 12865.9 10539.8 11133.900000000001 9150.6 10721.0 10734.1 10769.4 6600.2 11499.2 True False 10323.8494106125 11359.55444680536 9108.553050977245 9189.573374187652 8322.92984566965 10613.15647388916 9924.418194926513 10483.760528058709 11200.057340464855 12975.234331693302 0.7956580318087566 0.8754797143862378 0.701995264064611 0.7082394921948503 0.6414473629458903 0.8179548979678516 0.7648739083413032 0.8079823654861539 0.8631872885029598 1.0 13.663472973324827 -8.570560792586145 1.0200433206708144 0.9993355517542717 0.7530152602093217 0.5980553901946951 0.06161098832647986 0.45553009029559877 1.032554612314237 0.06364595543172627 0.020934655521091496 2.688061541597385e-09 8.570560792586145 -0.24632029154494994 LSSS(ph)LDNKEK ddPTM_A459_Selumetinib_30min_R1 1 LSSSLDNKEK 10 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 LSS(0.004)S(0.996)LDNKEK 129.74 0.013752 10945000.0 2473.6 2464.1 3556.2 3277.7 2406.6 2556.1 2040.8 2552.0 1590.2 2092.9 True False 2531.230067212263 2175.6020264709878 3073.2875728083345 2705.3112250491617 2188.923454919738 2530.387954753107 1886.860812942493 2484.312669935728 2698.4532563872644 2361.544101572361 1.0718538203571646 0.921262501522809 1.3013890237163395 1.1455687925742797 0.926903483810576 1.0714972263564024 0.7989945272189435 1.0519865660275518 1.1426647736921716 1.0 11.205514762570909 -6.251166327358801 24.631165280456212 0.9949309014234768 1.1102052841109624 0.16609696010930497 0.12204898787396085 1112.1690719944197 2666589.597377438 0.03738041507475613 0.04768307667190961 5.608331453941477e-07 6.251166327358801 0.11527438268748558 LSSS(ph)SATLLNSPDR ddPTM_A459_Selumetinib_30min_R1 1 LSSSSATLLNSPDR 14 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 LSS(0.025)S(0.815)S(0.14)AT(0.02)LLNSPDR 191.63 0.00010737 23434000.0 1958.3 2312.6 2010.2 2072.6 2074.6 1927.3 2209.8 1857.3 1129.3 1958.8 True False 2003.9245798115203 2041.8397169014272 1737.2258812382092 1710.6593175204844 1886.9527963003777 1907.9131118483883 2043.1130068798143 1808.0383706393532 1916.3396191913814 2210.2310603277483 0.9066584104172188 0.9238127875185362 0.7859928821109777 0.7739730692531377 0.8537355347909044 0.8632188489675237 0.9243888765986518 0.8180313828234975 0.867031349612476 1.0 11.109981483312273 -6.9843719810516545 4.390636635174405 0.8881284679886862 0.8459426500028272 0.12814341013672959 0.06149029460948204 0.5618653563284794 26.42441499829787 0.024181107547028707 0.020270901504352384 1.0366401344978069e-07 6.9843719810516545 -0.042185817985858964 LSSS(ph)SATLLNSPDR ddPTM_A459_Selumetinib_30min_R2 2 LSSSSATLLNSPDR 14 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 LSS(0.058)S(0.501)S(0.44)ATLLNSPDR;LS(0.008)S(0.041)S(0.934)S(0.016)AT(0.001)LLNSPDR 228.03 3.5812e-13 31968000.0 109606.0 73170.0 98892.0 104959.0 96423.0 88876.0 77832.0 94310.0 62953.0 79870.0 True False 103514.53730758223 78781.90372136766 92529.39638546857 90663.40313562579 84309.48070744293 101117.86226399972 81451.34222118222 94584.42648613894 75545.35905378578 77563.94557281808 1.3345702896251117 1.0157026327058898 1.192943392733944 1.1688859104067852 1.0869674058585899 1.3036709455305997 1.050118603684422 1.2194380493104469 0.9739751955096557 1.0 16.24309857280278 -8.269843461515007 24.8753690813054 0.9869875581280707 1.164506019700111 0.3659977141613501 0.09680493009291503 662.9694817985396 1962307.1215844208 0.08020183835618601 0.022104800667553586 5.372254007093704e-09 8.269843461515007 0.1775184615720402 LSSS(ph)VSAMR ddPTM_A459_Selumetinib_30min_R1 1 LSSSVSAMR 9 0 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4M5;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 LS(0.008)S(0.15)S(0.839)VS(0.002)AMR 102.95 0.01567 7013400.0 1053.6 1735.3 1431.3 1513.3 1487.1 1276.5 1327.8 1283.6 708.97 1047.7 True False 1078.1468300512781 1532.1302692809159 1236.9373215681262 1249.030563159196 1352.5920675688287 1263.659568969267 1227.6429769820868 1249.5547582795848 1203.0703088799385 1182.1825004622124 0.9119969460127704 1.2960183970595742 1.0463167244351068 1.0565463138481979 1.1441482740947266 1.068920888674294 1.0384547026386368 1.056989726874684 1.0176688526598552 1.0 10.207237054684928 -7.700427252288966 0.8321748237086813 1.004645883281981 1.09936274220463 0.09640795889481191 0.09052799397096395 1.347267902055374 1.7280316779018978 0.07717476160821553 0.03505474971190461 1.993300371551374e-08 7.700427252288966 0.09471685892264903 LSSSDRYS(ph)DASDDSFSEPR ddPTM_A459_Selumetinib_30min_R1 1 LSSSDRYSDASDDSFSEPR 19 1 Q9NRF8 Q9NRF8 CTPS2 CTP synthase 2 1 LSSSDRYS(0.756)DAS(0.239)DDS(0.003)FSEPR 156.58 1.4935e-05 7699700.0 441.97 471.22 327.96 553.49 572.7 296.98 424.7 470.19 181.28 305.47 True False 452.2670410760852 416.0493433357651 283.4248333553292 456.83336179408104 520.8993861183974 293.9926508362655 392.6645370720686 457.71903380763314 307.61891983265167 344.6800500297719 1.3121358228798574 1.2070595420298582 0.8222838349096452 1.3253838211832156 1.5112548175428326 0.8529436235455802 1.1392145760630823 1.3279533694163541 0.8924767180638419 1.0 8.429113988172288 -8.276921164943454 24.602098747660133 0.9462383175095458 1.1784276179787398 0.18253001006259495 0.20335246257968784 1382.8540581116479 2197466.4583710167 0.19581460767140232 0.05135553477782971 5.285411862031429e-09 8.276921164943454 0.23218930046919406 LSSSGAPPADFPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 LSSSGAPPADFPSPR 15 0 Q8NG08 Q8NG08 HELB DNA helicase B 1 LSSSGAPPADFPS(1)PR;LSSSGAPPADFPS(1)PR;LSSSGAPPADFPS(1)PR 208.38 8.5351e-10 63358000.0 7743.6 8856.7 9555.6 9552.5 8898.5 7293.3 8375.3 7858.6 4207.28 6937.4 True False 7924.010813577327 7819.753446631873 8258.002005153627 7884.335197633133 8093.632246157772 7219.93602378657 7743.544378007287 7650.164399669634 7139.44687242674 7827.882865998426 1.0122801974971352 0.9989614791756959 1.0549470586770642 1.0072116985653832 1.0339490746998359 0.9223357256848383 0.9892258878377607 0.977296739185925 0.9120533603585191 1.0 12.93440645274899 -6.745824245317183 24.99543209355567 0.9605786060923973 1.0212871631810887 0.5236179495436997 0.02922742793968837 192.77896383139597 308584.24959923816 0.009327123726597225 0.009295882547266189 1.7954600847714537e-07 6.745824245317183 0.060708557088691384 LSSSGAPPADFPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 LSSSGAPPADFPSPR 15 0 Q8NG08 Q8NG08 HELB DNA helicase B 1 LSSSGAPPADFPS(1)PR;LSSSGAPPADFPS(1)PR;LSSSGAPPADFPS(1)PR;LSSSGAPPADFPS(1)PR 211.45 9.6609e-07 69649000.0 120989.0 114460.0 136933.0 149915.0 154272.0 124218.0 120807.0 130140.0 107054.0 133307.0 True False 114264.9157373416 123238.71395309246 128122.87986137779 129496.31838220058 134890.97215082112 141327.90196126647 126424.76487452906 130518.68585416306 128467.79133868062 129458.08053681799 0.8826402744697313 0.9519584520492197 0.9896862314820088 1.000295368548831 1.0419664156263928 1.0916885324981525 0.9765691284027168 1.008192654432594 0.9923505030042854 1.0 16.982125492873443 -4.816636612115751 1.1817092914221714 1.0190222127183055 0.8251665407180159 0.6564058172033521 0.030238808570055037 0.950028538932874 1.1683957346076481 0.01001390834538852 0.22520129197647737 1.5253285104410017e-05 4.816636612115751 -0.19385567200028964 LSSSSATLLNS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 4 LSSSSATLLNSPDR 14 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 LSSSSATLLNS(1)PDR;LSSSSATLLNS(1)PDR;LSSSSATLLNS(1)PDR;LSSSSATLLNS(1)PDR 254.94 4.327e-28 356780000.0 9562.0 10659.900000000001 9471.0 11217.3 10310.8 8370.5 9330.4 7682.4 4585.18 7923.0999999999985 True False 9784.77599558687 9411.83395234694 8184.890220479096 9258.409129799546 9378.189960519594 8286.300369805913 8626.600416051868 7478.637796047903 7780.7155717027745 8940.10706252949 1.09448085209154 1.0527652394449045 0.9155248548179337 1.0356038317040015 1.049001974464739 0.9268681361251404 0.9649325624083835 0.8365266482537981 0.8703157039711468 1.0 13.126076393213353 -7.022194161665589 1.8076835841615522 0.8990098294477828 1.0248873061069965 0.41839994170171024 0.06204271595645728 0.34311159342677444 2.2500416432161545 0.029505047869931515 0.022169374237187688 9.501798981868177e-08 7.022194161665589 0.12587747665921367 LSSSSATLLNS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 4 LSSSSATLLNSPDR 14 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 LSSSSATLLNS(1)PDR;LSSSSATLLNS(1)PDR;LSSSSATLLNS(1)PDR;LSSSSATLLNS(1)PDR 233.47 1.1881e-13 536918000.0 174380.0 119041.0 173239.0 187619.0 180342.0 136125.0 133740.0 154466.0 118733.0 145102.0 True False 164688.65769844863 128171.06192285541 162092.99134836183 162064.9685391721 157685.82568206431 154874.98313028226 139959.1750007823 154915.47048677728 142482.91767720567 140912.5282397277 1.1687297059795263 0.9095788963831816 1.1503092973578675 1.1501104306599255 1.119033400733546 1.0990859724466864 0.9932344323754982 1.099373295064489 1.0111444273770063 1.0 17.10444035880134 -8.316608721870894 5.839859943816933 1.002921488614827 1.082981747667895 0.15465262125274382 0.07510081633308405 0.4622559365568315 34.29786516112285 0.07025071433359602 0.018651759807601836 4.823822047260234e-09 8.316608721870894 0.0800602590530679 LSSSSATLLNS(ph)PDRAR ddPTM_A459_Selumetinib_30min_R1 2 LSSSSATLLNSPDRAR 16 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 LSSSSATLLNS(1)PDRAR;LSSSSATLLNS(1)PDRAR 120.74 0.00086899 36258000.0 2726.7 1719.92 4572.3 4809.0 4759.2 3204.5 2831.1000000000004 2662.7 1836.24 2166.7 True False 2790.2268047653934 1518.550966830884 3951.4067738461154 3969.198426110202 4328.731200305003 3172.2656394532055 2617.5478476683143 2592.076546331452 3115.9651663366544 2444.8170504452364 1.1412824547576077 0.6211307167357712 1.6162382265480795 1.6235155204710936 1.7705746937247016 1.2975472495479734 1.070651829424873 1.0602333396927992 1.274518748046686 1.0 11.255510794710482 -7.1710956793611285 5.275874054158329 1.1071709103189153 1.3596678363534618 0.13217828624540717 0.3069119766819018 0.5517419324621256 24.7162646488168 0.13416285294560368 0.10292522074765946 6.743794388837879e-08 7.1710956793611285 0.25249692603454643 LSSSSPGATVS(ph)PSSSDAEYDKLPDADLAR ddPTM_A459_Selumetinib_30min_R1 1 LSSSSPGATVSPSSSDAEYDKLPDADLAR 29 1 Q8NI08-2;Q8NI08;Q8NI08-7;Q8NI08-4;Q8NI08-3 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 LSSSSPGAT(0.01)VS(0.819)PS(0.158)S(0.01)S(0.002)DAEYDKLPDADLAR 131.26 5.5191e-14 47187000.0 1664.3 1914.0 2370.7 2383.4 2202.6 1837.8 1910.6 1852.2 888.73 1514.7 True False 1703.074951835936 1689.90799020554 2048.7719613229624 1967.1839319590483 2003.3752189006145 1819.3134005888905 1766.4819037671155 1803.0736392064864 1508.109899728999 1709.1264994274252 0.9964592746098568 0.9887553617427829 1.1987245894375413 1.150987906757092 1.1721632187973012 1.0644697166642605 1.0335583143546747 1.0549679264879075 0.8823863536339944 1.0 10.739043465375769 -7.816469622788266 1.5339132310020465 0.9503388799855024 1.099624883808118 0.3631418134034011 0.07347862728655272 0.47337061727748936 2.064998343570058 0.06455080735070942 0.02416935254922624 1.5259151229093613e-08 7.816469622788266 0.1492860038226156 LSSSTVAISYS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 3 LSSSTVAISYSPDR 14 0 Q96T17-5;Q96T17;Q96T17-2 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 LSSSTVAISYS(1)PDR;LSSSTVAISYS(1)PDR;LSSSTVAISYS(1)PDR 222.75 4.5322e-09 44013000.0 5452.8 6271.2 5454.5 5326.8 6241.0 5310.099999999999 5678.8 5408.2 3124.1400000000003 5160.3 True False 5579.839630698184 5536.964988598218 4713.8088594238425 4396.574376420014 5676.502651938044 5256.685215185035 5250.443543971892 5264.756967690599 5301.437401842348 5822.6747705785565 0.9582949160912445 0.9509315231851856 0.8095607337099245 0.7550781298374251 0.9748960530340616 0.9027956089436053 0.9017236494990074 0.9041818708977074 0.9104814558130615 1.0 12.507466322981934 LSSSTVAISYS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 2 LSSSTVAISYSPDR 14 0 Q96T17-5;Q96T17;Q96T17-2 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 LSSSTVAIS(0.005)YS(0.995)PDR;LSSSTVAISYS(1)PDR 166.52 0.00023132 35138000.0 40847.0 33450.0 47578.0 43623.0 48541.0 34978.0 36745.0 40225.0 40673.0 36559.0 True False 38576.88726349659 36015.50744129774 44516.883279009635 37681.47214612766 42442.84561795411 39795.90200132978 38453.715308836174 40342.048090392775 48808.73649857235 35503.44667831051 1.0865673863451597 1.014422846537321 1.2538749739530373 1.061346873940206 1.1954570496357741 1.1209024960847416 1.083098090651802 1.1362853994409006 1.3747605110235734 1.0 15.115671467950786 -5.235072880428463 24.850580110412707 1.1526523748122104 1.0504951062257246 0.14227117312463344 0.10087907685326085 1339.6037679375265 1262579.1334819938 0.024477504759521793 0.06471676344509887 5.8200554125358695e-06 5.235072880428463 -0.10215726858648577 LSST(ph)PPLSALGR ddPTM_A459_Selumetinib_30min_R1 1 LSSTPPLSALGR 12 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 1 LS(0.002)S(0.093)T(0.905)PPLSALGR 142.76 0.002062 25470000.0 2485.9 4060.6 3882.6 4397.6 3558.8 3317.1 3783.6 3489.5 1541.3 2554.6 True False 2543.8166332806286 3585.183064278276 3355.3642455951976 3629.641713175763 3236.9071683571715 3283.7329856858228 3498.200005806163 3396.9471245065524 2615.4735279019555 2882.5077939112016 0.8825012160085051 1.2437722013627697 1.1640434252017717 1.2591958019481344 1.1229482796870758 1.1391930986698944 1.2135960267637453 1.178469363268337 0.9073604357381757 1.0 11.493108793396667 -8.256935246099363 24.916075181984283 0.9536802082135823 1.1584635734209277 0.37371611916314673 0.10147633212347204 326.120411709592 1804069.1827050643 0.0707592600750478 0.024659536227707182 5.534326206242025e-09 8.256935246099363 0.2047833652073453 LSST(ph)TTT(ph)T(ph)GLRVT(ph)QGK ddPTM_A459_Selumetinib_30min_R1 1 LSSTTTTTGLRVTQGK 16 1 Q9UKJ1-2;Q9UKJ1 Q9UKJ1-2 PILRA Paired immunoglobulin-like type 2 receptor alpha 4 LS(0.1)S(0.116)T(0.526)T(0.157)T(0.178)T(0.962)T(0.962)GLRVT(0.999)QGK 58.246 0.044307 0.0 249.11 247.03 265.09 320.61 290.24 280.23 218.91 130.23 179.87 196.56 True False 254.91377831631917 218.10761275886867 229.092234035139 264.62148209507023 263.98784324603383 277.4111406284822 202.39744245454784 126.7758773533424 305.2262528149773 221.79039065653564 1.1493454588439693 0.9833952323778982 1.0329222711452408 1.1931151810127913 1.190258254492392 1.2507807024790394 0.9125618195423999 0.571602209536965 1.3761924126264349 1.0 7.793053050078309 -7.283454320047942 23.80214223202863 0.9293892422586585 1.1272337406403896 0.1393532943282042 0.19661208007351802 762.9875654259724 824922.8003532476 0.08052601087081127 0.05435365930508275 5.2064976889344925e-08 7.283454320047942 0.19784449838173113 LSSTPPLS(ph)ALGR ddPTM_A459_Selumetinib_30min_R2 1 LSSTPPLSALGR 12 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 1 LS(0.032)S(0.17)T(0.17)PPLS(0.628)ALGR 107.39 0.008502500000000001 5528700.0 53295.0 36817.0 50426.0 53221.0 52118.0 35261.0 32368.0 39505.0 34560.0 38297.0 True False 50333.07725678876 39640.74551468635 47181.64605967754 45972.2079886541 45570.47089916839 40117.882682511554 33873.17613597525 39619.953009595185 41472.9656870814 37191.266102444184 1.3533574554344334 1.065861683909739 1.2686216685851628 1.2361022575037541 1.2253003372792821 1.0786909639485232 0.9107830866169175 1.0653026143412576 1.1151264808474972 1.0 15.182676242009316 -6.8465058571747806 4.101550041279964 1.0244871045969728 1.2237480421014904 0.5906320985663598 0.08231486920183395 0.16232622610441075 5.142255011304909 0.029304240532504945 0.02604690685438103 1.423948042237366e-07 6.8465058571747806 0.19926093750451757 LSSWDQAET(ph)PGHT(ph)PSLR ddPTM_A459_Selumetinib_30min_R2 1 LSSWDQAETPGHTPSLR 17 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 2 LSSWDQAET(1)PGHT(0.896)PS(0.104)LR 121.91 0.005543600000000001 3136100.0 12734.0 10426.0 12762.0 16558.0 11846.0 13101.0 13188.0 10903.0 11958.0 13208.0 True False 12026.295258240894 11225.640675126162 11940.90681421499 14302.771835856796 10357.79957541633 14905.543830962928 13801.268131526243 10934.725924911188 14349.93413443631 12826.650721494709 0.9376021472298618 0.8751809742752565 0.9309450357297558 1.1150823505226057 0.8075217607710238 1.1620760676038713 1.0759837802707362 0.8525004821864323 1.1187592494733567 1.0 13.646856884482391 -5.543765812086812 24.41139858170562 1.0130723597694788 0.9055593772719975 0.1632409713908577 0.10857741861531336 306.230334855285 357899.6028670865 0.028434702269087963 0.04925706995333408 2.859131879171001e-06 5.543765812086812 -0.10751298249748131 LSSWDQAET(ph)PGHTPSLR ddPTM_A459_Selumetinib_30min_R1 1 LSSWDQAETPGHTPSLR 17 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LSSWDQAET(0.924)PGHT(0.047)PS(0.028)LR 152.59 0.00038244 9680300.0 1137.0 1372.2 912.14 970.09 953.56 1050.5 1137.8 1365.5 381.71 826.26 True False 1163.4898877831279 1211.5421860815266 788.2763980263751 800.6819923446143 867.3106663646913 1039.9329237776847 1051.9748299519647 1329.2825042308918 647.7339910046425 932.3185194539537 1.247953208592883 1.299493854086595 0.8455011689439118 0.8588073449549869 0.93027291453211 1.1154266509548252 1.1283427369522725 1.4257815076004652 0.6947561133763721 1.0 9.864679114537186 -5.2389892156113005 24.66181248987203 1.0162605845057915 1.2737236170042263 0.24849381799352444 0.18878709184244408 1036.0689473922062 1138130.9487000287 0.049467647928137806 0.13064971674955933 5.767807858191252e-06 5.2389892156113005 0.25746303249843483 LSSWDQAETPGHT(ph)PSLR ddPTM_A459_Selumetinib_30min_R1 3 LSSWDQAETPGHTPSLR 17 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LSSWDQAET(0.001)PGHT(0.682)PS(0.317)LR;LSSWDQAET(0.001)PGHT(0.934)PS(0.065)LR;LSSWDQAETPGHT(0.595)PS(0.405)LR 115.02 0.002274 17327400.0 8708.8 9794.0 6585.0 7282.200000000001 10251.2 8098.799999999999 11438.7 11410.9 2867.15 7342.1 True False 8911.69809562507 8647.313926892928 5690.793168815838 6010.500473824022 9323.980769996353 8017.333425122048 10575.869649649801 11108.24586417304 4865.344141649314 8284.53005311025 1.0757035146826903 1.0437905193724875 0.6869180427053133 0.7255089226898885 1.1254688811824474 0.9677475214314796 1.2765805159556778 1.3408420022572902 0.5872806436163177 1.0 13.016204146348194 -6.282716588843692 24.351220608957714 1.073946447176791 0.8804622308764631 0.11311057436530547 0.22244178180150992 1175.8272310712769 1345700.2620456736 0.07055850094661144 0.08009212140257203 5.215349424672811e-07 6.282716588843692 -0.19348421630032786 LSSWDQAETPGHT(ph)PSLR ddPTM_A459_Selumetinib_30min_R2 4 LSSWDQAETPGHTPSLR 17 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LSSWDQAETPGHT(0.993)PS(0.007)LR;LSSWDQAETPGHT(0.994)PS(0.006)LR;LSSWDQAETPGHT(0.676)PS(0.324)LR;LSSWDQAETPGHT(0.651)PS(0.349)LR 207.37 7.240499999999999e-09 37021700.0 134826.0 105685.0 136736.0 152405.0 171441.0 136089.0 136393.0 153743.0 145088.0 126621.0 True False 127332.91067124129 113790.69966916439 127938.5546269003 131647.17608671053 149903.04887801394 154834.02445705788 142735.54475760224 154190.36667647617 174109.65409743198 122965.12272913239 1.0355205431033503 0.9253900386032434 1.0404458743047278 1.0706058202918478 1.2190696479701844 1.259170251048554 1.160780728630021 1.2539357767009005 1.4159271363552475 1.0 16.90788964853038 -6.073032316964247 1.8551797079122223 1.2336284913976194 0.9863496800850419 0.490476876736767 0.10126677172398196 0.2702577742232344 1.8521006853153679 0.032651564005736905 0.04984068136249783 8.45215948137594e-07 6.073032316964247 -0.24727881131257756 LSSWDQAETPGHTPS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 LSSWDQAETPGHTPSLR 17 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LSSWDQAETPGHT(0.361)PS(0.639)LR 136.46 0.00033995 9241200.0 3787.1 4488.0 2983.1 2652.3 4146.7 3226.4 4464.3 4535.9 1246.9 3466.8 True False 3875.332061586177 3962.5428735854066 2578.011404995373 2189.1255948372013 3771.631717159345 3193.945345336814 4127.55425677145 4415.593197320325 2115.8982300272164 3911.797549491644 0.990678073840962 1.0129723799485373 0.6590349762171096 0.5596213932701318 0.964168433933777 0.8164904509825366 1.0551553868905728 1.1287887835335833 0.5409017729719134 1.0 11.933615991889278 LST(ph)GSFPEDLLESDSSR ddPTM_A459_Selumetinib_30min_R1 1 LSTGSFPEDLLESDSSR 17 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 LS(0.114)T(0.882)GS(0.003)FPEDLLESDSSR 163.34 1.9209e-05 0.0 436.57 330.52 391.46 442.89 366.37 375.95 472.28 370.46 193.88 417.04 True False 446.74123158265616 291.82256474542055 338.3018821358615 365.5475755749528 333.2318981878772 372.1682843352883 436.65553936519046 360.63419737632813 329.00019956506276 470.5711463136018 0.9493595922367397 0.6201454700984617 0.7189176063727623 0.7768168074872608 0.7081434992314682 0.7908863245245915 0.9279267179594368 0.7663754996486576 0.6991508130968315 1.0 8.878269052312156 -6.999282122899746 24.658371553086212 0.8332533960612425 0.7467529197897763 0.13285495746113596 0.10930318522524292 45.365050232933164 1558155.5654874996 0.037717564240208515 0.03296953100870469 1.0016543400227496e-07 6.999282122899746 -0.08650047627146618 LST(ph)IQNSPTK ddPTM_A459_Selumetinib_30min_R2 3 LSTIQNSPTK 10 0 Q5VYV7 Q5VYV7 SLX4IP Protein SLX4IP 1 LS(0.059)T(0.93)IQNS(0.011)PTK;LS(0.024)T(0.975)IQNS(0.001)PTK;LS(0.046)T(0.95)IQNS(0.004)PTK 187.58 0.00043724 69500000.0 308753.0 289726.0 309841.0 309582.0 306517.0 208510.0 247920.0 273185.0 195446.0 253906.0 True False 291593.7442961876 311947.0525840791 289906.1673893738 267416.3975412618 268009.59416325233 237230.35983467536 259448.7712441602 273979.9231217889 234540.66121751466 246575.07405298567 1.1825759169539092 1.2651199793092056 1.1757318476038534 1.0845232372668683 1.0869289817415229 0.9621019510824429 1.0522100509981318 1.1111420088752129 0.9511937170385479 1.0 17.91166744142133 -5.843610117288652 1.5675680507465655 1.0281662810227061 1.2285329623449968 0.7276455485595619 0.05009621961535287 0.20210572668160773 1.0107448992452794 0.0163193383753827 0.03301198753635341 1.4334742062415399e-06 5.843610117288652 0.20036668132229063 LSTAS(ph)EETVQNR ddPTM_A459_Selumetinib_30min_R1 2 LSTASEETVQNR 12 0 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 LST(0.001)AS(0.917)EET(0.082)VQNR;LST(0.001)AS(0.864)EET(0.136)VQNR 168.82 1.2610999999999997e-05 4898600.0 1549.2399999999998 1409.29 1525.21 1706.03 1631.77 1236.81 1406.22 1182.06 651.85 1170.04 True False 1585.3342777037217 1244.289671638854 1318.0948593788326 1408.103886649364 1484.1766916123918 1224.3688143336292 1300.1476932457833 1150.707928927988 1106.141840759676 1320.2260311547268 1.2008051956960126 0.9424823039964941 0.9983857523442178 1.066562735032406 1.124183781101685 0.927393329203442 0.9847917421448037 0.8715991820896979 0.8378427743862893 1.0 10.36656923402591 -6.822537791421051 9.383368496062346 0.919685242415715 1.0557287168718366 0.4467930437783255 0.0785591771751971 0.35457835534999876 51.21724142388387 0.0280475068814185 0.02476561533016278 1.504742573472084e-07 6.822537791421051 0.13604347445612153 LSTASCPT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 LSTASCPTPK 10 0 H0YJ30;G3V582;F5H039;Q9NQX3;Q9NQX3-2 H0YJ30 GPHN Gephyrin;Molybdopterin adenylyltransferase;Molybdopterin molybdenumtransferase 1 LST(0.001)AS(0.001)CPT(0.998)PK 145.23 0.0021261999999999995 4471100.0 2969.5 4142.0 3813.6 4583.7 3385.3 3101.0 3861.0 3437.1 2316.4 3363.7 True False 3038.6835723588356 3657.052714436442 3295.734066605327 3783.242841705417 3079.10021272326 3069.806755482721 3569.761661491065 3345.9369427257407 3930.7616168377917 3795.4636602126016 0.8006093179637043 0.9635325330006173 0.8683350340444881 0.996780151359294 0.8112579880558743 0.8088094183757162 0.9405337479350562 0.8815621073653803 1.0356472802107164 1.0 11.890060423116926 -8.258061511033887 24.801904909543335 1.0178236495139013 0.8867836556524975 0.41054578468264014 0.06410288495041797 242.86827340973858 1783292.5966530228 0.046725850739546326 0.016020613278452837 5.519992516667455e-09 8.258061511033887 -0.13103999386140375 LSTEADTDT(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 LSTEADTDTPK 11 0 Q9BYW2;H7C3H4;A0A1W2PPX9 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 LSTEADT(0.002)DT(0.998)PK;LSTEADT(0.03)DT(0.97)PK;LSTEADT(0.334)DT(0.666)PK;LSTEADT(0.497)DT(0.503)PK 168.31 0.001138 37421900.0 15464.9 19393.4 21668.6 21637.5 14038.199999999999 16287.400000000001 14576.8 14659.599999999999 11241.2 15992.699999999999 True False 15825.202080542911 17122.811712252933 18726.12313709991 17858.916811178944 12768.44728864551 16123.563543775983 13477.260240150996 14270.779786908222 19075.495375236133 18045.518827089825 0.8769602155625591 0.9488677979459516 1.0377159735074153 0.989659370966339 0.7075688657661421 0.8934940412780699 0.7468480329819619 0.7908212517273271 1.0570765827247988 1.0 14.13935300233623 -4.424216885173417 16.568269205360004 0.8972968201335888 0.00020720515182757462 0.0 0.11703354344946419 14470987.637884557 20399415.275624324 0.03046224142730245 479964353.32645655 3.7651572136641194e-05 4.424216885173417 -0.8970896149817612 LSTEADTDT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 LSTEADTDTPK 11 0 Q9BYW2;H7C3H4;A0A1W2PPX9 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 LSTEADT(0.001)DT(0.999)PK 212.68 4.599600000000001e-05 13549000.0 103450.0 113530.0 92716.0 85764.0 78039.0 62156.0 85367.0 74966.0 57288.0 86212.0 True False 97700.66314316171 122237.38594351354 86750.75350154832 74082.79524884785 68235.04314248814 70717.42480400969 89336.73465150138 75184.13864871059 68747.20076046068 83722.83555432326 1.1669535855575388 1.4600244381856877 1.0361659746373544 0.8848576945387796 0.8150111339482056 0.8446611290192738 1.0670533798814728 0.8980123302193657 0.8211284329453259 1.0 16.353333553671554 -5.459037606734446 4.4270635232176945 0.9033216441706151 1.310040236989766 0.7252329397652991 0.0993600850111888 0.10394935392288124 4.001394582048075 0.026344955124577508 0.05596092070259312 3.475060686494348e-06 5.459037606734446 0.4067185928191508 LSTGS(ph)FPEDLLESDSSR ddPTM_A459_Selumetinib_30min_R1 1 LSTGSFPEDLLESDSSR 17 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 LS(0.004)T(0.021)GS(0.974)FPEDLLES(0.001)DSSR 91.401 0.016286000000000002 0.0 508.98 506.01 463.01 711.94 479.97 430.33 426.88 431.12 191.2 462.4 True False 520.838243697323 446.766113962333 400.13578513187906 587.6130437689541 436.55679824558604 426.00127090837805 394.6800979169401 419.68529712487884 324.45243530451813 521.753544157418 0.9982457225823486 0.8562780626316924 0.7669057347335513 1.126227220397502 0.8367107480804629 0.8164798795882245 0.7564492897778216 0.8043745975940239 0.6218499882515944 1.0 9.027224685104185 -6.511167817110188 23.990647656596405 0.7895263876731066 0.9268182453896407 0.21620892516480883 0.12242112690975217 514.0277138421826 1053024.4637441058 0.03815455601984202 0.04093687694193712 3.0819967959541463e-07 6.511167817110188 0.13729185771653418 LSTGS(ph)FPEDLLESDSSR ddPTM_A459_Selumetinib_30min_R2 1 LSTGSFPEDLLESDSSR 17 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 LS(0.026)T(0.089)GS(0.884)FPEDLLESDSSR 66.738 0.040464 6916900.0 740.77 700.76 949.59 484.13 748.96 632.62 666.06 572.57 541.86 500.55 True False 699.6009689372625 754.5060387014587 888.4944132354187 418.1906588291674 654.8689490126474 719.7576626474132 697.0331097728515 574.2360839059338 650.247140833389 486.0978209149134 1.439218484091334 1.5521691442297731 1.8278099078147088 0.8603014472314771 1.347195812933454 1.4806848162633497 1.4339358865277863 1.1813179553554265 1.337687833303841 1.0 8.925102856585246 -9.744883969765052 0.05272203594044074 6.178241251515414e-09 2.317813239456483 0.2533284211824197 0.22731270990944183 195.29649110945223 2.801992015415855 74.7760918420769 48.51469091078093 1.7993515827595532e-10 9.744883969765052 2.317813233278242 LSTIQNS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 LSTIQNSPTK 10 0 Q5VYV7 Q5VYV7 SLX4IP Protein SLX4IP 1 LS(0.34)T(0.229)IQNS(0.389)PT(0.042)K 115.92 0.0064967 26857000.0 4120.4 5157.7 5386.3 5972.8 4627.5 4214.6 4297.6 4517.0 2464.7 3997.3 True False 4216.39730309727 4553.834086250324 4654.87004482806 4929.762603341864 4208.9434420514835 4172.204950550624 3973.428571982389 4397.1944867161765 4182.415885434339 4510.392391999236 0.9348182899954627 1.0096314667274064 1.0320321693263552 1.0929786534950992 0.9331656929710865 0.9250203946671012 0.8809496439889929 0.9749028697627604 0.9272842630839218 1.0 12.139037234188418 -6.310631125299037 24.61664187973588 0.9352420285590368 1.0178604098060091 0.39448996883571885 0.04657645328601501 313.04119647580484 156651.7748759934 0.014682176397928095 0.01664804891327687 4.890675800555269e-07 6.310631125299037 0.0826183812469723 LSTIQNS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 LSTIQNSPTK 10 0 Q5VYV7 Q5VYV7 SLX4IP Protein SLX4IP 1 LS(0.119)T(0.133)IQNS(0.486)PT(0.262)K 105.66 0.012376 19089000.0 88931.0 98020.0 97861.0 92593.0 98348.0 66923.0 75098.0 89307.0 61198.0 81771.0 True False 83988.57103899961 105537.81881602421 91564.72980300071 79981.67366816566 85992.6449977245 76141.0357834922 78590.2058038639 89566.86858443021 73439.31001498853 79410.05876342689 1.0576565783588288 1.3290233058564456 1.1530621086150332 1.007198268250143 1.082893607394348 0.9588336410923264 0.9896757039054026 1.1279033157658502 0.9248111783139965 1.0 16.27703414269834 -5.66806863512401 4.333224277593818 1.0179245114804167 1.2034159694421218 0.46634432151307637 0.08197508316573772 0.16965103013931743 5.714341470535981 0.02143258432213239 0.038088388431293065 2.1474910616604895e-06 5.66806863512401 0.18549145796170508 LSTTPSPTS(ph)S(ph)LHEDGVEDFRR ddPTM_A459_Selumetinib_30min_R2 1 LSTTPSPTSSLHEDGVEDFRR 21 1 C9J919;C9JNL1;O94842-3;O94842-2;O94842 C9J919 TOX4 TOX high mobility group box family member 4 2 LS(0.01)T(0.011)T(0.051)PS(0.371)PT(0.308)S(0.584)S(0.665)LHEDGVEDFRR 54.964 0.027128 7288400.0 13520.0 12493.0 14891.0 14764.0 13467.0 9560.5 14695.0 11629.0 9573.5 13034.0 True False 12768.612524848191 13451.172928673617 13932.929272094923 12753.117730679427 11775.15506349246 10877.372093421955 15378.34661759008 11662.838464715414 11488.467505939625 12657.674553601006 1.008764482826399 1.0626891117884578 1.1007495265495761 1.007540340579484 0.9302779127104769 0.8593499577951647 1.2149424882483697 0.9214045135484568 0.9076286056565777 1.0 13.627724759185531 -5.98013015715804 9.043330534009227 0.9742740567464377 1.057455960705587 0.14549894741764613 0.09232353661343777 0.4856292496397338 195.5647314793751 0.02675777354051089 0.03928072516284406 1.0468147728119112e-06 5.98013015715804 0.08318190395914915 LSVGEQPDVTHDPYEFLQS(ph)PEPAASAK ddPTM_A459_Selumetinib_30min_R1 3 LSVGEQPDVTHDPYEFLQSPEPAASAK 27 0 Q9H8M2;Q9H8M2-2;Q9H8M2-3;Q9H8M2-1;Q9H8M2-6 Q9H8M2 BRD9 Bromodomain-containing protein 9 1 LSVGEQPDVTHDPYEFLQS(0.999)PEPAAS(0.001)AK;LSVGEQPDVTHDPYEFLQS(1)PEPAASAK;LSVGEQPDVTHDPY(0.01)EFLQS(0.989)PEPAAS(0.001)AK 143.48 5.6783e-13 54423000.0 9343.0 10262.0 10651.4 11188.199999999999 10903.1 9738.900000000001 10615.1 10267.2 5542.1 8824.7 True False 9560.673721686679 9060.520269325632 9204.998383952166 9234.390898524884 9916.916530098646 9640.935508213704 9814.394460733964 9994.880503434208 9404.538921031224 9957.4362048572 0.9601541526344922 0.9099250131179293 0.9244345828158058 0.92738639832012 0.9959307120904487 0.9682146397795541 0.9856346813396142 1.0037604356991754 0.9444739315973448 1.0 13.281558616245675 -6.253429760356646 24.839656405757694 0.9825826481153325 0.928575712974665 0.6251285265912923 0.019903951197624444 346.92771470936606 1075900.3678314285 0.005646628746636088 0.007152822438336556 5.57917828432591e-07 6.253429760356646 -0.054006935140667456 LSVGEQPDVTHDPYEFLQS(ph)PEPAASAK ddPTM_A459_Selumetinib_30min_R2 2 LSVGEQPDVTHDPYEFLQSPEPAASAK 27 0 Q9H8M2;Q9H8M2-2;Q9H8M2-3;Q9H8M2-1;Q9H8M2-6 Q9H8M2 BRD9 Bromodomain-containing protein 9 1 LSVGEQPDVTHDPYEFLQS(0.999)PEPAAS(0.001)AK;LSVGEQPDVTHDPY(0.002)EFLQS(0.997)PEPAAS(0.001)AK 116.45 5.5519e-12 32193000.0 122214.0 120429.0 109796.0 123780.0 129331.0 92926.0 96594.0 102135.0 86174.0 106889.0 True False 115421.83514140516 129665.51705973208 102731.84489684584 106920.95046758979 113083.28354619017 105725.71300176014 101085.81239737982 102432.1959406405 103411.20790273594 103802.8368390254 1.1119333407081946 1.2491519596984986 0.9896824405305953 1.0300388093766635 1.089404557618754 1.0185243122566745 0.9738251426995288 0.9867957279384333 0.9962271846491364 1.0 16.663486346241164 -5.271142419802603 24.994527923529986 1.012574391145686 1.1805426520428555 0.7110487950790578 0.04332804637736049 315.98046927417107 813950.4161585618 0.011566220260509096 0.024557281520683268 5.356209805320463e-06 5.271142419802603 0.16796826089716954 LSVGSVTS(ph)RPSTPTLGTPTPQTMSVSTK ddPTM_A459_Selumetinib_30min_R2 1 LSVGSVTSRPSTPTLGTPTPQTMSVSTK 28 1 Q16594;D6RIE8 Q16594 TAF9 Transcription initiation factor TFIID subunit 9 1 LSVGS(0.014)VT(0.057)S(0.29)RPS(0.29)T(0.29)PT(0.057)LGT(0.001)PTPQTMSVSTK 81.315 3.2037e-05 10134000.0 12174.0 12384.0 9943.2 13650.0 14770.0 10425.0 10554.0 11694.0 8813.4 11158.0 True False 11497.417816383275 13333.812979163857 9303.4653373376 11790.846452436614 12914.460554524667 11860.949121272304 11044.781912354254 11728.027603954091 10576.326266971148 10835.83954803437 1.061054638675313 1.2305288316660818 0.8585827887258867 1.0881340942867213 1.1918283301700754 1.0946036131943178 1.0192825266001457 1.0823367725190767 0.9760504684558292 1.0 13.403523315617209 -8.063188706417774 1.4247279850519565 0.9892751014262224 1.084151739440809 0.11553075754243936 0.09489889707428269 0.9916036671614032 3.6217702335179087 0.08749237711446957 0.028672709791786218 8.64592160971439e-09 8.063188706417774 0.09487663801458646 LSVGSVTSRPST(ph)PTLGTPTPQTMSVSTK ddPTM_A459_Selumetinib_30min_R2 1 LSVGSVTSRPSTPTLGTPTPQTMSVSTK 28 1 Q16594;D6RIE8 Q16594 TAF9 Transcription initiation factor TFIID subunit 9 1 LSVGS(0.019)VT(0.071)S(0.061)RPS(0.371)T(0.442)PT(0.032)LGT(0.002)PTPQTMSVSTK 78.707 0.00010712 12387000.0 30478.0 26186.0 30774.0 31731.0 30742.0 27724.0 21767.0 31043.0 26483.0 26480.0 True False 28784.154773100818 28194.381998739085 28794.034344197767 27409.183060971878 26879.915123032995 31542.72934658546 22779.208630492234 31133.3299905547 31780.33999684538 25715.453596697433 1.1193329592598549 1.096398393002098 1.119717147353594 1.0658642655438895 1.045282558285696 1.2266059872510438 0.8858178816420997 1.2106856242486452 1.2358459817689875 1.0 14.650347981263712 LSVHDMKPLDS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 LSVHDMKPLDSPGR 14 1 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 LSVHDMKPLDS(1)PGR;LSVHDMKPLDS(1)PGR 78.508 0.016250999999999998 22774000.0 149768.0 139944.0 177868.0 218770.0 241040.0 161102.0 137487.0 157274.0 143172.0 212200.0 True False 141444.49412880634 150677.2548091172 166424.16652803533 188973.14860070046 210758.40027505916 183292.33816165102 143880.41792532214 157731.64130188784 171810.40055991974 206073.23463818745 0.686379744449332 0.7311830431238118 0.8075971963085558 0.9170193738769111 1.0227354398794082 0.889452424442534 0.6982004149056029 0.7654154678496932 0.8337346713733853 1.0 17.652797610258624 -14.522878732675304 0.020220038147845728 2.019554736640498 2.2479718128561484e-07 0.21850815603332463 0.10053612963356949 7022.496460735015 10.708934525845788 723.7940383683866 392.5410004778636 3.000000087072489e-15 14.522878732675304 -2.0195545118433165 LSVHDMKPLDS(ph)PGRR ddPTM_A459_Selumetinib_30min_R1 1 LSVHDMKPLDSPGRR 15 2 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 LSVHDMKPLDS(1)PGRR 56.90600000000001 0.03791 21450000.0 4165.8 4444.0 4682.6 6008.3 6891.1 4750.8 5622.2 4420.7 2057.4 2972.4 True False 4262.8550347642495 3923.69441404045 4046.7286396806467 4959.063194759395 6267.801221722523 4703.0112653812685 5198.112927540811 4303.448675542662 3491.257533449349 3353.9364936278293 1.2710005221814074 1.169877372900503 1.2065609016059364 1.478579932619821 1.868789475778915 1.4022362302674953 1.5498543092323744 1.2831038046542678 1.040943243881456 1.0 11.711639656571025 -8.15991302809 3.017439755000015 1.0077299405155598 1.4218604834790476 0.4130948559977372 0.18841169207166938 0.2964141998300307 4.840853387674587 0.17881378454258492 0.05615913856520216 6.919695310173562e-09 8.15991302809 0.41413054296348784 LSVHDMKPLDS(ph)PGRR ddPTM_A459_Selumetinib_30min_R2 2 LSVHDMKPLDSPGRR 15 2 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 LSVHDMKPLDS(1)PGRR;LSVHDMKPLDS(1)PGRR 70.167 0.020547 26265000.0 87268.0 82094.0 125531.0 170421.0 189899.0 109048.0 97020.0 106531.0 92135.0 141260.0 True False 82417.99392148305 88390.34582618524 117454.47212781895 147209.3658073774 166042.1899014001 124068.37216081546 101531.62224148292 106840.98757284367 110564.57446699208 137181.45676244277 0.6007954417936118 0.644331587608454 0.8561978776126787 1.0730995958316727 1.2103836321620018 0.904410662263667 0.7401264328115812 0.7788296617804569 0.8059731765238274 1.0 17.065725955620458 -5.297960414359102 3.5323684453764885 0.9259229775985183 0.6124861165245933 0.44924945498258595 0.13426609222329614 0.24011245182321467 6.2545086255546405 0.041745902087975885 0.10698418564976414 5.035465046109368e-06 5.297960414359102 -0.313436861073925 LSVPTS(ph)DEEDEVPAPK ddPTM_A459_Selumetinib_30min_R2 2 LSVPTSDEEDEVPAPK 16 0 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 LSVPT(0.036)S(0.964)DEEDEVPAPK;LSVPT(0.025)S(0.975)DEEDEVPAPK 250.46 2.0032e-29 7607600.0 89745.0 65628.0 73867.0 79789.0 85463.0 70777.0 82583.0 91763.0 82372.0 61239.0 True False 84757.33217769966 70661.45657272017 69114.47764030877 68921.60055629782 74726.3738910861 80525.88930036352 86423.27313510996 92030.01513781762 98848.70166597988 59470.87095196956 1.4251906995973238 1.1881691900861593 1.1621568094425199 1.158913590015538 1.2565205905835368 1.3540391793723454 1.453203421300286 1.547480533993588 1.662136438960395 1.0 15.859895583712976 -6.944650562763957 2.3456637451067426 1.4606719087893851 1.22434645496318 0.16815016933326243 0.17625101494903309 0.40460686436845883 4.509132919248792 0.07021098180164863 0.05767205480409131 1.1359244230554476e-07 6.944650562763957 -0.23632545382620518 LSVPTS(ph)DEEDEVPAPKPR ddPTM_A459_Selumetinib_30min_R1 3 LSVPTSDEEDEVPAPKPR 18 1 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 LSVPT(0.037)S(0.963)DEEDEVPAPKPR;LSVPT(0.035)S(0.965)DEEDEVPAPKPR;LSVPT(0.155)S(0.845)DEEDEVPAPKPR 207.81 9.324e-12 285013000.0 14266.78 22392.58 21749.1 25595.35 20425.44 19884.800000000003 19956.789999999997 17399.41 9311.08 15070.89 True False 14599.168215678601 19770.846323571976 18795.69167925475 21125.60260672485 18577.962558404324 19684.77696595384 18451.43326299619 16937.92112555111 15800.222705623391 17005.38553440007 0.8585026306017026 1.1626226458422642 1.105278774258489 1.2422889539310957 1.0924752350261686 1.1575613458532679 1.0850346924314607 0.9960327621674625 0.9291305200732578 1.0 14.053704093755277 -7.775055476074889 3.1779840398888557 0.9642259941320191 1.1123607705615324 0.27211919099336657 0.09436827807515379 0.30696171494555663 6.341544649244143 0.0557119864809728 0.025781814393366922 1.6785895841078344e-08 7.775055476074889 0.14813477642951323 LSVPTS(ph)DEEDEVPAPKPR ddPTM_A459_Selumetinib_30min_R2 6 LSVPTSDEEDEVPAPKPR 18 1 Q5STZ8;Q8NE71;Q8NE71-2;F5GYK6 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 LSVPT(0.063)S(0.937)DEEDEVPAPKPR;LSVPT(0.019)S(0.981)DEEDEVPAPKPR;LSVPT(0.032)S(0.968)DEEDEVPAPKPR;LSVPT(0.213)S(0.786)DEEDEVPAPKPR;LSVPT(0.041)S(0.959)DEEDEVPAPKPR;LS(0.002)VPT(0.063)S(0.936)DEEDEVPAPKPR 302.4 4.207499999999997e-95 457842700.0 575240.0 568503.0 622340.0 601635.0 615788.0 408061.0 443596.0 494217.0 408231.0 533942.0 True False 543270.4636681706 612105.3520747403 582299.3219525582 519691.27512173535 538427.2062254327 464267.69874105486 464224.0929687988 495655.0896479713 489888.60692716687 518525.70711207896 1.047721368905521 1.1804725275509518 1.1229902663759246 1.002247849997926 1.038380930473428 0.8953610059697652 0.8952769102891501 0.9558929920919732 0.9447720724505522 1.0 18.984055990194207 -6.126145105180102 1.4454526640208472 0.9369563803537446 1.1243381390909173 0.6802102639837806 0.049838892479569734 0.22097274492888935 0.9281740601720537 0.01802656116212446 0.028231446640295723 7.479195660997286e-07 6.126145105180102 0.18738175873717267 LSVPYVPQVTDEDRLS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 LSVPYVPQVTDEDRLSR 17 1 A0A1B0GUZ7;Q14156-3;Q14156-2;Q14156 A0A1B0GUZ7 EFR3A Protein EFR3 homolog A 1 LSVPYVPQVT(0.011)DEDRLS(0.989)R;LSVPYVPQVT(0.002)DEDRLS(0.998)R 131.41 0.00043214 7045200.0 2411.1 1962.05 3315.9 2162.53 2987.3 1907.55 2224.6 3021.6 1541.47 2356.95 True False 2467.273938816094 1732.3322738677018 2865.6189929349207 1784.8847312156572 2717.0992424506517 1888.3617789168218 2056.796630964266 2941.4573524599527 2615.7620054856475 2659.487491137166 0.927725340705068 0.6513782372132823 1.0775079794451732 0.6711386074060687 1.0216627269372307 0.7100472497839725 0.7733808253727877 1.1060241351999063 0.983558679709066 1.0 11.376932535939522 -7.759044491738213 24.9996852069602 1.0335935696774123 0.8319329808388124 0.29797645628179115 0.13823828235631863 72.09138452471132 752572.6722072484 0.06370225725048552 0.034531339424566085 1.7416284413617027e-08 7.759044491738213 -0.20166058883859994 LSVQSNPS(ph)PQLR ddPTM_A459_Selumetinib_30min_R1 1 LSVQSNPSPQLR 12 0 O75152;E9PBY7;E9PQ61;A0A1W2PPR9 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 LSVQSNPS(1)PQLR 154.13 0.00045044 17294000.0 2001.6 2516.8 2793.9 2802.5 2399.2 2418.9 2336.7 2426.1 1337.7 2077.1 True False 2048.2333855643865 2222.1318859714224 2414.503725794164 2313.095984440393 2182.1927836131645 2394.568062185476 2160.4408377120376 2361.7519469165645 2269.979198257604 2343.716017667329 0.8739255823335488 0.9481233516435502 1.0302031933874347 0.9869352630625394 0.931082420892047 1.021697186918046 0.9218014560749971 1.0076954413902015 0.9685385008875288 1.0 11.194582057185384 -4.845446357533599 3.5727733882849972 0.9815935822933481 0.8684619734240496 0.4903590268996314 0.03382027990029388 0.20451542075793425 4.367016884530532 0.008161872351543196 0.05556183005373269 1.4274261297328719e-05 4.845446357533599 -0.11313160886929852 LSVQSNPS(ph)PQLR ddPTM_A459_Selumetinib_30min_R2 4 LSVQSNPSPQLR 12 0 O75152;E9PBY7;E9PQ61;A0A1W2PPR9 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 LSVQSNPS(1)PQLR;LS(0.001)VQS(0.267)NPS(0.731)PQLR;LS(0.001)VQS(0.008)NPS(0.991)PQLR;LSVQS(0.001)NPS(0.999)PQLR 145.52 0.00068097 38689200.0 176928.0 178613.0 184848.0 205855.0 192570.0 141438.0 147877.0 144409.0 125153.0 177548.0 True False 167095.050058901 192312.04276868468 172955.08092728478 177817.1938803176 168377.63500235724 160919.80065367022 154753.57351271654 144829.20628180317 150187.0970669934 172421.72791489598 0.9691066902042408 1.1153585171330969 1.0030933051120567 1.031292262469871 0.9765453405354177 0.9332918919191966 0.8975294203587839 0.8399707393797147 0.8710450758336143 1.0 17.395582063132316 -6.673711369004564 1.471938672315024 0.8887585418319626 1.0370801967902026 0.5459532513544294 0.052120573862813234 0.26347926277837963 1.187140178739362 0.021759798218152538 0.021224028493425463 2.119769460542282e-07 6.673711369004564 0.14832165495824 LSYLPATVEPASPT(ph)PAHSLPR ddPTM_A459_Selumetinib_30min_R1 3 LSYLPATVEPASPTPAHSLPR 21 0 E9PCV4;M0R344;Q9NRA0-4;Q9NRA0-2;Q9NRA0;Q9NRA0-5 E9PCV4 SPHK2 Sphingosine kinase 2 1 LSYLPAT(0.054)VEPAS(0.168)PT(0.778)PAHSLPR;LSYLPATVEPAS(0.024)PT(0.962)PAHS(0.014)LPR;LSYLPATVEPAS(0.028)PT(0.972)PAHSLPR 190.31 3.5867e-16 83981300.0 5381.3 7107.6 6974.3 7031.4 6644.6 5950.5 6505.6 5711.4 3087.38 4787.3 True False 5506.673819812968 6275.438887766404 6027.228367087668 5803.497985724949 6043.597103199412 5890.6433726217165 6014.877354311391 5559.9151187581965 5239.058366686526 5401.796587250884 1.0194152502538898 1.1617318028186137 1.1157821790833264 1.0743644067275961 1.1188124183467556 1.0904970739780522 1.1134957152047298 1.0292714708807247 0.9698733156764091 1.0 12.399223598687101 -7.92628726804506 3.53328879932277 0.9871818968982501 1.1016490424845604 0.6365992250055691 0.03533764119413126 0.13816377107460756 3.3838409799383675 0.021688313516721038 0.009076418691579293 1.1849846699629768e-08 7.92628726804506 0.11446714558631033 LSYLPATVEPASPT(ph)PAHSLPR ddPTM_A459_Selumetinib_30min_R2 1 LSYLPATVEPASPTPAHSLPR 21 0 E9PCV4;M0R344;Q9NRA0-4;Q9NRA0-2;Q9NRA0;Q9NRA0-5 E9PCV4 SPHK2 Sphingosine kinase 2 1 LSYLPAT(0.009)VEPAS(0.259)PT(0.731)PAHS(0.001)LPR 140.32 3.8307e-05 0.0 18284.0 20192.0 19771.0 22450.0 21130.0 20348.0 19287.0 18787.0 18968.0 18204.0 True False 17267.84847665121 21740.661472486816 18498.955385037178 19392.271271589878 18475.460495403266 23150.7522992469 20183.883716465472 18841.66705964472 22762.13001020139 17678.4032203278 0.9767764804004182 1.2297864915473793 1.0464155135779374 1.0969469940187448 1.0450864970745184 1.3095499639145367 1.141725497767621 1.0658014089179344 1.2875670798156693 1.0 14.109700350537322 LSYLS(ph)APGSEYSMYSTDSR ddPTM_A459_Selumetinib_30min_R1 2 LSYLSAPGSEYSMYSTDSR 19 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 LSYLS(0.996)APGS(0.004)EYSMYSTDSR;LSYLS(1)APGSEYSMYSTDSR 235.79 7.4231e-25 12585400.0 5190.4 4147.6 3701.1000000000004 3484.6000000000004 5044.9 3175.3 5493.3 4742.6 2123.1 5027.1 True False 5311.326221239708 3661.997063833073 3198.510948687063 2876.080024043172 4588.589685749438 3143.359364941724 5078.935958318798 4616.810841864103 3602.7456349112063 5672.3772531006825 0.936349256096531 0.6455841881516822 0.563874863389713 0.5070325713035087 0.8089359154032262 0.5541520291555845 0.8953804959891388 0.8139111056727447 0.6351385802031844 1.0 12.469737769827406 -7.2689091959196555 24.993832127320267 0.8206001366406979 0.6624188178396848 0.2338984966040627 0.14648658848025303 957.250328367132 3202923.074731142 0.06024626962774647 0.04153592175294759 5.383823379474155e-08 7.2689091959196555 -0.15818131880101305 LSYLS(ph)APGSEYSMYSTDSR ddPTM_A459_Selumetinib_30min_R2 4 LSYLSAPGSEYSMYSTDSR 19 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 LSYLS(0.726)APGS(0.23)EYS(0.03)MYS(0.006)T(0.006)DS(0.001)R;LS(0.001)Y(0.005)LS(0.896)APGS(0.055)EY(0.007)S(0.018)MY(0.003)S(0.007)T(0.007)DS(0.001)R;LSYLS(0.981)APGS(0.018)EYS(0.001)MYSTDSR;LSYLS(0.999)APGS(0.001)EYSMYSTDSR 217.65 4.3238e-19 11483300.0 60081.1 55293.6 58245.1 65367.0 66503.0 49973.1 73289.0 68498.0 74564.0 55483.0 True False 56742.03298569944 59534.44132305354 54497.673678469924 56463.90183563546 58148.298595636676 56856.44091436482 76697.08371939835 68697.31783954568 89478.8834922319 53881.061627853625 1.0530979025173262 1.1049233167350478 1.0114439476875032 1.0479359561550776 1.0791973439064 1.0552212446566398 1.4234516062272622 1.2749807773652486 1.660674099375505 1.0 15.717490656299013 -7.254661885143103 24.317625793657815 1.3626916894897056 1.0590436045136544 0.442159084930839 0.15384211145827018 304.0028103955334 1090763.6960344 0.055381838859488726 0.041871127825515414 5.563372185030361e-08 7.254661885143103 -0.3036480849760512 LSYLSAPGSEY(ph)SMYSTDSR ddPTM_A459_Selumetinib_30min_R1 1 LSYLSAPGSEYSMYSTDSR 19 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 LSYLSAPGS(0.03)EY(0.504)S(0.378)MY(0.048)S(0.019)T(0.019)DS(0.004)R 102.97 0.045036 0.0 485.98 699.43 537.89 489.25 664.61 555.63 741.96 693.78 340.82 481.62 True False 497.30238844753256 617.5404104438143 464.84749241827654 403.81167185993286 604.4961428464259 550.0408666716756 685.9933598445772 675.3787006849568 578.3466474920809 543.4406183760716 0.9150997765562484 1.1363530615160315 0.8553786314452354 0.7430649425260429 1.1123499466285802 1.0121452980738304 1.2623152128276438 1.2427828871223268 1.0642315423906237 1.0 9.085978590703965 -6.629748260130437 2.315360061710051 1.1489505958719026 0.9277705108987676 0.3468377219101578 0.12664673553468583 0.3302725905859909 3.6082275499109233 0.04824614694045795 0.04840355186867835 2.3455880472482495e-07 6.629748260130437 -0.22118008497313502 LSYLSAPGSEYSMYST(ph)DSR ddPTM_A459_Selumetinib_30min_R2 2 LSYLSAPGSEYSMYSTDSR 19 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 LSYLSAPGSEY(0.001)S(0.002)MY(0.007)S(0.03)T(0.774)DS(0.187)R;LSYLSAPGS(0.008)EYS(0.055)MYS(0.121)T(0.549)DS(0.268)R 141.1 0.00037376 6288600.0 40511.0 30761.0 40916.0 47996.0 57658.0 35626.0 36714.0 42148.0 33408.0 35449.0 True False 38259.560798382 33120.269787795514 38283.50910597248 41458.86200228187 50414.486570940004 40533.15811937146 38421.273747410836 42270.64370202301 40090.533497512006 34425.49526243685 1.111372850462043 0.9620854989974384 1.1120685066147842 1.2043069151577155 1.4644520343604013 1.1774168479022273 1.1160703267887027 1.2278877436556834 1.1645593822801592 1.0 15.071189789393259 -5.592214278404763 3.7571151283927824 1.2099040391734845 1.0359447102653205 0.2225439855221103 0.11516401679347582 0.28944109469616836 8.127421727884236 0.03234391955950159 0.060997328142890855 2.557323806691075e-06 5.592214278404763 -0.173959328908164 LSYLSAPGSEYSMYSTDS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 LSYLSAPGSEYSMYSTDSR 19 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 LSYLSAPGSEYS(0.001)MYS(0.047)T(0.077)DS(0.875)R;LSYLSAPGS(0.032)EY(0.003)S(0.225)MYS(0.082)T(0.253)DS(0.405)R 234.51 3.2789999999999997e-24 13296600.0 63834.0 43028.0 66960.0 77110.0 76119.0 50414.0 62300.0 64533.0 53582.0 56027.0 True False 60286.36182774846 46328.10924317363 62651.86650053558 66607.48497783065 66556.25070750601 57358.07088727313 65197.07344510799 64720.78034598678 64299.897206168855 54409.35493437189 1.108014640137994 0.851473231010627 1.1514907055249182 1.2241917783839202 1.2232501338746913 1.0541950176850645 1.1982695535307881 1.1895156710468713 1.1817801788631175 1.0 15.731567103766007 -5.372948600668366 8.406146699765063 1.1634734487721146 0.9803424563090565 0.3675731637946298 0.0900541914996416 0.25706114639372035 17.40461971449582 0.022116572675741738 0.046190474193948186 4.23693107727165e-06 5.372948600668366 -0.18313099246305808 LT(ph)GLGQSNAALR ddPTM_A459_Selumetinib_30min_R1 1 LTGLGQSNAALR 12 0 Q08378-2;Q08378 Q08378-2 GOLGA3 Golgin subfamily A member 3 1 LT(1)GLGQSNAALR 94.122 0.026249 271410000.0 3384.6 5930.4 5053.1 5515.5 4483.8 4019.2 4422.8 3722.6 2082.2 3417.5 True False 3463.4545947148417 5236.0660110318395 4366.916774691467 4552.321463757708 4078.241081679186 3978.770497141618 4089.184635183291 3623.8645552910443 3533.341322129014 3856.16941426898 0.8981593448407698 1.357841279394217 1.1324494091293213 1.1805294256296825 1.0575886698827273 1.0317934897826266 1.060426603678792 0.9397576107215783 0.9162826998872494 1.0 11.912952719984292 -6.937493213129518 1.0007229892354732 0.9545346781164639 1.1570686169246687 0.3033649842385283 0.1101383283666675 0.5956386181949413 1.2480840562931754 0.06628858455241171 0.05063615636992243 1.1548000310090179e-07 6.937493213129518 0.2025339388082048 LT(ph)PEEEEILNK ddPTM_A459_Selumetinib_30min_R2 2 LTPEEEEILNK 11 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 LT(1)PEEEEILNK;LT(1)PEEEEILNK 149.23 0.004567 0.0 21778.0 16129.5 20113.8 24045.0 20764.1 17587.9 21330.0 22594.0 13500.5 17237.3 True False 20567.665944241395 17366.58078548316 18819.700006249597 20770.029520061416 18155.528124590764 20010.473577940073 22321.88726459317 22659.744799361953 16200.977235487328 16739.614361116037 1.2286821846993936 1.0374540542477182 1.1242612643434207 1.240771087792053 1.084584610668434 1.1953963303014805 1.3334767924190674 1.3536599058098744 0.9678226084538785 1.0 14.030978671731972 -6.96467524010764 23.46958623273359 1.203386514879551 1.1414862489010935 0.0 0.12968415681292492 327.698171788468 217718.5866811214 0.045091685418761095 0.03976688861110266 1.0847377639213305e-07 6.96467524010764 -0.06190026597845755 LT(ph)PIVHSPLR ddPTM_A459_Selumetinib_30min_R2 1 LTPIVHSPLR 10 0 Q96KQ4;A0A3B3ISJ2;H0YJL1 Q96KQ4 PPP1R13B Apoptosis-stimulating of p53 protein 1 1 LT(0.659)PIVHS(0.341)PLR 89.35600000000002 0.041969 2429100.0 5953.5 7099.1 7830.3 9767.1 11478.0 6255.5 7911.2 7912.5 6228.3 8999.6 True False 5622.628303748796 7643.578142795714 7326.507022986023 8436.804130812723 10036.031025378072 7117.138343224832 8279.086475745404 7935.5240650151045 7474.134033242153 8739.75816423106 0.6433391174094901 0.8745754744196872 0.8382963104140563 0.9653361079648374 1.148319076659607 0.8143404210373836 0.9472901103406919 0.9079798223127706 0.8551877400717233 1.0 13.093377644469012 -4.230007827651968 1.1704219533497977 0.9407775206986526 2.773298022883284e-14 0.4946332021595812 0.08933014081876903 4.326607534194176 2.042207817588563 0.02753323258839523 6.812148611240621 5.888330422305053e-05 4.230007827651968 -0.9407775206986249 LT(ph)PPPADLPLALPAHGLWSR ddPTM_A459_Selumetinib_30min_R1 1 LTPPPADLPLALPAHGLWSR 20 0 Q15742 Q15742 NAB2 NGFI-A-binding protein 2 1 LT(1)PPPADLPLALPAHGLWSR 98.887 0.0026376 0.0 189.09 369.14 122.75 225.45 286.46 117.43 288.01 252.75 117.06 217.11 True False 193.49542909490904 325.92091719146987 106.08122421748588 186.07938972063744 260.54974357862073 116.2487608179091 266.28517382181866 246.04624895229443 198.64227027587285 244.9781833304866 0.789847595668856 1.33040792759814 0.4330231483281821 0.7595753515308258 1.0635630489067975 0.47452699353674405 1.0869750530502873 1.004359839750983 0.8108569815292307 1.0 7.936509464707154 -10.349967469866646 5.6513690224471835 1.0000000317148456 0.8650540941727174 0.02448829524527729 0.2614376143974273 1.0163307680029844e-07 2.107763377345155e-08 0.2459642275107278 0.05965507387748787 4.4671705152389366e-11 10.349967469866646 -0.13494593754212825 LT(ph)PPPADLPLALPAHGLWSR ddPTM_A459_Selumetinib_30min_R2 2 LTPPPADLPLALPAHGLWSR 20 0 Q15742 Q15742 NAB2 NGFI-A-binding protein 2 1 LT(1)PPPADLPLALPAHGLWSR;LT(1)PPPADLPLALPAHGLWSR 160.12 1.3076e-06 36313000.0 51702.0 28332.0 43495.0 44889.0 42024.0 36427.0 42068.0 51077.0 37684.6 33240.0 True False 48828.609819504505 30504.97329826151 40696.579053775364 38775.04076215582 36744.5694206733 41444.48859861739 44024.245356160594 51225.62561374746 45222.572995699826 32280.27483210812 1.512645418090936 0.945003518616862 1.2607259159174142 1.2011992141896999 1.1382979113958689 1.2838951593247878 1.3638125940728094 1.586901780736855 1.4009351912555104 1.0 14.97836524122684 -7.08887259839958 3.2204498084454602 1.3863521662853795 1.1993477139758857 0.06469244831744547 0.19003827410673077 0.4581312230450527 9.096505893200247 0.07346897151902805 0.056457234983816704 8.149433150463353e-08 7.08887259839958 -0.1870044523094938 LT(ph)PVSPESSSTEEK ddPTM_A459_Selumetinib_30min_R1 2 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LT(0.747)PVS(0.253)PESSSTEEK;LT(0.996)PVS(0.004)PESSSTEEK 224.34 5.4782e-09 2859250000.0 8069.200000000001 7211.7 6055.1 5791.7 4949.5 5200.4 5598.8 5884.4 3560.9 4788.6 True False 8257.196660070022 6367.350811371624 5232.850678283491 4780.288318673835 4501.818598905201 5148.08869758541 5176.478008380262 5728.326596775003 6042.587222154074 5403.26345491395 1.5281869427559722 1.1784268645240485 0.9684611387076677 0.8847039124709798 0.8331665920918703 0.9527739560623361 0.9580280605552483 1.0601605205027393 1.1183217832287442 1.0 12.399615311959936 -4.837329018781276 2.1151260387626927 0.9644235802170841 1.6432875187708271 0.8328705036093262 0.07662366106816573 0.2517403841278856 1.4194553226386335 0.023371705793583476 0.31717615671971106 1.454356851465777e-05 4.837329018781276 0.678863938553743 LT(ph)PVSPESSSTEEK ddPTM_A459_Selumetinib_30min_R2 3 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LT(0.999)PVS(0.001)PESSSTEEK;LT(0.996)PVS(0.004)PESSSTEEK;LT(1)PVSPESSSTEEK 172.85 0.00026885 1507584500.0 122556.0 104913.2 109038.0 112823.0 102926.0 88963.3 112068.9 105254.6 83355.6 102969.3 True False 115744.82815053951 112959.70509089233 102022.61379159795 97456.3127694692 89995.51570988527 101217.18704656938 117280.3259103124 105560.87346016306 100029.04915006015 99996.30876262928 1.1574910072460174 1.129638748556564 1.0202637982745812 0.9745991024609767 0.8999883778061863 1.012209233511191 1.1728465516533397 1.0556477010640755 1.0003274159600088 1.0 16.60958722015544 -5.217939329961342 4.078881398782534 1.0182691956771692 1.1498586508456445 0.3813632296432594 0.06480951757554045 0.2589565995847143 9.403170362293922 0.01919733202470762 0.05429124743990101 6.054254455260492e-06 5.217939329961342 0.1315894551684753 LT(ph)RTSGETTQTHTEPTGDSK ddPTM_A459_Selumetinib_30min_R1 2 LTRTSGETTQTHTEPTGDSK 20 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 LT(0.226)RT(0.226)S(0.226)GET(0.081)T(0.081)QT(0.156)HT(0.005)EPTGDSK;LT(0.362)RT(0.261)S(0.362)GET(0.006)T(0.008)QT(0.001)HTEPTGDSK 87.51100000000002 0.0029279 12100900.0 1765.01 2480.1 3035.9 4136.6 2716.7 2187.2 2944.3 2217.56 1157.16 1914.8400000000001 True False 1806.131298888388 2189.72873903279 2623.641455005013 3414.220463598976 2470.97496467234 2165.198753818707 2722.209080530471 2158.7431051499507 1963.6160043774917 2160.628366121086 0.8359287174086693 1.0134684767487097 1.214295570744154 1.5801979262766175 1.1436371952796354 1.002115304866531 1.2599154594168245 0.9991274478292073 0.9088170993064926 1.0 11.077235230778301 -7.91041388482617 6.426944326122923 0.9543242475451003 1.1573160765913446 0.16725009258402412 0.18578411290794405 0.38806394315217085 22.57047288111318 0.11222996265952606 0.053124556367669926 1.2290968769834224e-08 7.91041388482617 0.20299182904624435 LT(ph)SDEEGEPSGK ddPTM_A459_Selumetinib_30min_R1 1 LTSDEEGEPSGK 12 0 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 LT(0.5)S(0.5)DEEGEPSGK 240.65 5.3654e-13 29130000.0 10011.0 12092.0 8411.6 8837.4 8251.9 7970.3 10407.0 9141.8 5353.8 8923.9 True False 10244.236821984945 10676.263018581712 7269.3509216114435 7294.113988543631 7505.5171019912705 7890.126018453385 9621.991611276228 8899.329767248602 9085.007573919089 10069.369491147021 1.0173662641927745 1.0602712541205555 0.7219271204619762 0.7243863674837445 0.745381039854592 0.783576968288866 0.9555704177640787 0.8838020866224925 0.9022419508894393 1.0 13.297685729182744 -9.577288966650833 12.062705802944954 0.9999989504868567 0.8605428421801793 0.10680958020152487 0.11521022647210725 0.0 0.0 0.12362898753586757 0.029984433764620663 2.646738491406947e-10 9.577288966650833 -0.13945610830667743 LT(ph)SDEEGEPSGKR ddPTM_A459_Selumetinib_30min_R2 1 LTSDEEGEPSGKR 13 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 LT(0.5)S(0.5)DEEGEPSGKR 160.56 0.0003013 0.0 40504.0 43099.0 45974.0 45641.0 47782.0 31198.0 28176.0 35119.0 27513.0 40813.0 True False 38252.94983035878 46404.55471487266 43016.082892706465 39424.61706488344 41779.197983500206 35495.24131275333 29486.239829684808 35221.190475736556 33016.368777449934 39634.62264509114 0.965139750992344 1.170808541067818 1.0853158178871707 0.9947014613438305 1.0541086352105 0.8955614799362677 0.7439515721827306 0.8886470496042126 0.8330183706577841 1.0 15.274473620340636 -6.809583856736059 3.9957512427983675 0.8526589905209657 1.0604501451635735 0.5711125902189829 0.07852692783110074 0.14597782268133017 4.837494130384836 0.02758067336839951 0.02493691154454943 1.5503014144242758e-07 6.809583856736059 0.20779115464260778 LTAEAIQT(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 LTAEAIQTPLK 11 0 Q53HL2 Q53HL2 CDCA8 Borealin 1 LTAEAIQT(1)PLK;LT(0.03)AEAIQT(0.97)PLK 119.21 0.011892 7481600.0 72603.0 60102.0 59360.0 68515.0 62057.0 79557.0 66873.0 54851.0 50100.0 73011.0 True False 68568.01591283683 64711.63014161067 55540.842226281304 59183.13880503261 54260.84486338098 90515.2546034591 69982.72700633558 55010.60732892815 60121.39991095999 70902.98272464023 0.9670681440741145 0.9126785313521383 0.7833357651818466 0.834705911243213 0.7652829652330583 1.2766071486017079 0.9870209167098293 0.7758574493624348 0.8479389385415317 1.0 16.11355869913742 -4.776689436444155 5.825969057824952 0.9051928957600246 0.9689790558068151 0.01339485250725403 0.14596276925174168 0.8867399026448197 102.21754315942567 0.038640839147484354 0.21566881713874064 1.6722860369333283e-05 4.776689436444155 0.0637861600467905 LTAEEMDER ddPTM_A459_Selumetinib_30min_R2 2 LTAEEMDER 9 0 P46940;A0A0J9YXZ5;H0YLE8;A0A087X225 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 ; 155.58 0.011444 8660500.0 61915.0 51589.0 62724.0 65249.0 76117.0 48824.0 48514.0 52966.0 43334.0 58956.0 False True 58474.01216538281 55545.71041522 58688.40612872758 56361.973639196796 66554.50196538623 55549.062819856015 50769.99712866729 53120.122291006686 52002.01085312458 57253.78709391599 1.0213125652188777 0.9701665729833006 1.0250571902336927 0.9844235027936875 1.162447155787509 0.9702251263962043 0.8867535180753537 0.9278010239544737 0.9082719850098879 1.0 15.805083504041308 -6.995028031851324 24.99982213088502 0.9252327898923174 1.0301270261006301 0.4309518304287402 0.05537249990095314 127.79213442666938 642553.3781645232 0.0195021897159642 0.017141629806692957 1.011514163239815e-07 6.995028031851324 0.10489423620831273 LTALNDSSLDLSMDSDNS(ph)MSVPSPTSATK ddPTM_A459_Selumetinib_30min_R1 1 LTALNDSSLDLSMDSDNSMSVPSPTSATK 29 0 P51003;G3XAH6;H0YJL4 P51003 PAPOLA Poly(A) polymerase alpha 1 LTALNDS(0.001)SLDLS(0.049)MDS(0.293)DNS(0.325)MS(0.325)VPS(0.007)PT(0.001)SATK 79.395 0.0012457 0.0 522.81 667.38 589.38 747.99 722.67 484.03 532.13 596.23 417.24 413.43 True False 534.9904557888273 589.2428393434551 509.34543323260147 617.3675880112644 657.3046260977512 479.16109766407686 491.9910056796789 580.4160435720141 708.0258059961145 466.49776764922444 1.1468231852099768 1.263120383861144 1.091849669076221 1.3234095226699651 1.409019874650292 1.0271455318610965 1.0546481458184034 1.2441989733345278 1.5177474686835013 1.0 8.865726367080914 -11.515354597146992 2.714939601961348 0.7854221800672914 1.22492001049564 0.1760224353685752 0.149360602344939 160798311.87027737 141041409.49344823 216223746.0727401 0.03841878553708601 3.0524278183697896e-12 11.515354597146992 0.43949783042834856 LTANETQS(ph)ASSTLQK ddPTM_A459_Selumetinib_30min_R1 1 LTANETQSASSTLQK 15 0 O95819-6;E7EN19 O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 LTANET(0.001)QS(0.807)AS(0.172)S(0.015)T(0.005)LQK 151.04 0.00041908 0.0 570.73 777.46 450.64 512.44 593.62 549.37 656.61 562.85 231.71 401.94 True False 584.0268985527393 686.4346217686522 389.4455631883324 422.9519736901463 539.9271758121234 543.8438365880498 607.0813790602559 547.921389605535 393.1949465711815 453.5329142271467 1.2877277044996038 1.513527685059831 0.8586930539583355 0.9325717283626205 1.190491712673597 1.1991276035936653 1.338560796838234 1.2081182476893284 0.8669601130079269 1.0 8.82506344498093 -5.246614163649568 24.99848601552889 1.0947299882059134 1.400627705491868 0.39047717094348466 0.16147260871427283 927.1931457090932 1563440.1876967954 0.043928424082202495 0.11520098492054412 5.667425714602311e-06 5.246614163649568 0.3058977172859547 LTANETQS(ph)ASSTLQK ddPTM_A459_Selumetinib_30min_R2 2 LTANETQSASSTLQK 15 0 O95819-6;E7EN19 O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 LT(0.001)ANET(0.001)QS(0.973)AS(0.021)S(0.004)TLQK;LTANETQS(0.651)AS(0.271)S(0.072)T(0.005)LQK 178.02 5.6835e-09 2397700.0 25745.0 18629.5 23380.0 27673.0 25160.0 23361.8 20795.5 21413.2 11808.1 19947.7 True False 24314.19596540064 20058.32274671618 21875.75625421929 23903.889661412337 21999.17586674616 26579.67589269444 21762.531955501505 21475.50886685391 14170.049945880362 19371.758070651133 1.2551362595343096 1.0354415264510874 1.1292602444463624 1.233955615914259 1.1356313550124113 1.3720838240780813 1.123415431688282 1.1085988576013672 0.7314798117032272 1.0 14.241667270233705 -8.096508038240303 4.8681375687928155 0.8691028313907811 1.1793846635056198 0.5848602663062332 0.10532135498321168 0.15395302911654649 5.782211747454537 0.07364011169983356 0.026649231150100545 8.007408076722958e-09 8.096508038240303 0.3102818321148386 LTANETQSAS(ph)STLQK ddPTM_A459_Selumetinib_30min_R2 1 LTANETQSASSTLQK 15 0 O95819-6;E7EN19 O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 LTANET(0.001)QS(0.073)AS(0.726)S(0.198)T(0.002)LQK 157.37 0.0001831 0.0 6784.3 5220.5 6169.1 6239.5 6769.4 6301.7 4658.9 4803.8 4220.5 3041.3 True False 6407.255765704701 5620.895563446783 5772.186822408219 5389.669336262142 5918.9674527961615 7169.701973862988 4875.54808143521 4817.778262688099 5064.717930622885 2953.489766753624 2.169384786034773 1.903136969262325 1.9543615445645548 1.8248478112000652 2.004058899889838 2.4275357424866524 1.65077534255155 1.631215491897112 1.714824946283749 1.0 11.528204897984018 -8.67526259114704 0.6962885764437722 1.0021868398801335 2.0163214974145 0.7018862008620668 0.1966450583677134 0.5364289147934111 0.5625644259907977 0.20741085804786671 0.07924169480606282 2.112211529331747e-09 8.67526259114704 1.0141346575343664 LTAQS(ph)EEK ddPTM_A459_Selumetinib_30min_R1 1 LTAQSEEK 8 0 H0Y4U7;Q8IUA7-4;Q8IUA7-3;Q8IUA7 H0Y4U7 ABCA9 ATP-binding cassette sub-family A member 9 1 LT(0.399)AQS(0.601)EEK 92.439 0.025462 8139700.0 1824.7 2225.8 2388.0 2624.9 2114.8 1999.6 2272.8 1829.8 1190.0 1782.5 True False 1867.2119597518677 1965.2023012536533 2063.722716345062 2166.5104904754994 1923.5167133982666 1979.485839491536 2101.3608661582225 1781.2677599719418 2019.3430858387903 2011.3012380203236 0.9283601702496441 0.9770800435582467 1.0260634644546511 1.0771685760050267 0.9563543625576141 0.9841816840126332 1.0447767974460864 0.8856295249562923 1.0039983308648397 1.0 10.97391345882212 LTASEQAHPQEPAES(ph)AHEPRLSAEYEK ddPTM_A459_Selumetinib_30min_R2 1 LTASEQAHPQEPAESAHEPRLSAEYEK 27 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 LT(0.003)AS(0.001)EQAHPQEPAES(0.632)AHEPRLS(0.28)AEY(0.085)EK 43.932 0.027268 13939000.0 19714.0 17032.0 23628.0 32132.0 40572.0 26118.0 23570.0 28719.0 26419.0 29260.0 True False 18618.374801394755 18338.29963348829 22107.80020422128 27755.566169208276 35474.98264171801 29715.51742440192 24666.051703068955 28802.5675353136 31703.53820853595 28415.187773389996 0.6552261751664483 0.6453696445624609 0.7780275949794918 0.9767863014159126 1.2484514592910523 1.045761782796651 0.8680587261917727 1.01363284188065 1.1157250995971033 1.0 14.794374628594982 -5.679695491720145 2.7062700156735824 1.0450620740857905 0.6575175435885412 0.7618615233248683 0.09085289596261358 0.13658810207404776 2.01803244240745 0.028609192244301345 0.05483769433332132 2.0907615675338984e-06 5.679695491720145 -0.38754453049724935 LTASEQAHPQEPAESAHEPRLSAEY(ph)EK ddPTM_A459_Selumetinib_30min_R2 1 LTASEQAHPQEPAESAHEPRLSAEYEK 27 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 LTASEQAHPQEPAES(0.023)AHEPRLS(0.454)AEY(0.523)EK 46.295 0.043804 18245000.0 27567.0 22898.0 34579.0 44006.0 48997.0 32264.0 33381.0 38551.0 32876.0 44750.0 True False 26034.936499444524 24654.202971325438 32354.22478676853 38012.30688541577 42841.55882126239 36708.0731365688 34933.28264319666 38663.17702753839 39452.11863219005 43457.95122553666 0.5990833844036794 0.5673116719970498 0.7444949399215262 0.8746916459117168 0.9858163492090243 0.8446802507109099 0.8038409924550067 0.8896686552682959 0.9078227923687138 1.0 15.407332541495476 -5.520073051749522 2.4487857309216166 0.894540857612731 0.5807124208970162 0.8369152825136243 0.05634209944821565 0.11367438506365364 1.3491420117809207 0.016654831443528768 0.03890636806191569 3.0194437834779273e-06 5.520073051749522 -0.3138284367157148 LTASPS(ph)DPK ddPTM_A459_Selumetinib_30min_R2 1 LTASPSDPK 9 0 E7EWD6;Q76L83;Q76L83-2;A0A5F9ZHN2 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 LT(0.001)AS(0.302)PS(0.697)DPK 82.831 0.040344 9519500.0 67885.0 73852.0 79964.0 76506.0 74758.0 57177.0 54635.0 56072.0 52053.0 64886.0 True False 64112.223465186304 79516.21092839228 74819.20329822047 66085.75081978853 65366.23169500034 65052.612748871645 57175.63575719869 56235.16023678068 62465.05448233933 63012.572585925634 1.0174512931964674 1.2619102452921096 1.1873694443469198 1.048770873934281 1.0373522142087628 1.0323751289500862 0.907368695020862 0.892443490703334 0.9913109704759364 1.0 15.943352090665377 -6.381531733331744 1.1616019862871085 0.9453733784966336 1.1622698213456906 0.5659973092327039 0.07061377677042853 0.3241131028438432 0.9108907115245374 0.031113511016809595 0.04068450170020794 4.154016972723171e-07 6.381531733331744 0.21689644284905696 LTAT(ph)PTPLGGMTGFHMQTEDR ddPTM_A459_Selumetinib_30min_R1 1 LTATPTPLGGMTGFHMQTEDR 21 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LT(0.034)AT(0.71)PT(0.256)PLGGMTGFHMQTEDR 115.88 0.00010426 12319000.0 1292.5 1332.1 1165.0 1504.4 1282.8 1553.8 1288.5 1129.2 935.04 1091.3 True False 1322.6127352327992 1176.1371127235113 1006.7993988869335 1241.6847810855043 1166.7709664967344 1538.1701827375207 1191.3074076226978 1099.2499478414672 1586.6945873804225 1231.3789851621766 1.0740907155067347 0.9551382043186406 0.8176194421202785 1.0083693128171831 0.9475319788270278 1.2491444155472076 0.967457965401122 0.892698317160815 1.2885509713091698 1.0 10.266059137358896 LTAT(ph)PTPLGGMTGFHMQTEDR ddPTM_A459_Selumetinib_30min_R2 1 LTATPTPLGGMTGFHMQTEDR 21 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LT(0.117)AT(0.487)PT(0.395)PLGGMTGFHMQTEDR 102.97 0.0010684000000000002 0.0 8815.7 7398.0 11228.0 7695.6 7228.7 6300.6 8781.8 6178.3 8668.4 8777.2 True False 8325.758686043204 7965.402811680737 10505.60270412208 6647.446004349537 6320.566080602063 7168.450458847796 9190.171100806572 6196.277830127373 10402.322215332646 8523.779430095652 0.9767684340407403 0.9344918972863837 1.2325052273207624 0.7798707203613012 0.741521543634211 0.8409943637839246 1.0781803044266998 0.7269401890257312 1.2203884791533037 1.0 13.057277545635312 -10.647877098007166 14.967487113052282 0.9999999998704375 0.9391026131030357 0.0056419345147999955 0.17464839160839635 0.0 0.0 0.16632171909170987 0.04033894209702525 2.2496911610297217e-11 10.647877098007166 -0.06089738676740186 LTATPT(ph)PLGGMTGFHMQTEDR ddPTM_A459_Selumetinib_30min_R2 1 LTATPTPLGGMTGFHMQTEDR 21 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 LT(0.002)AT(0.07)PT(0.927)PLGGMTGFHMQTEDR 145.52 4.6952e-06 2963700.0 20605.0 15364.0 23504.0 19174.0 25034.0 23944.0 20084.0 15837.0 15997.0 22525.0 True False 19459.856588350365 16542.36939695362 21991.778229220283 16562.468123005096 21889.005113200452 27242.068658009037 21017.94579569101 15883.083048043503 19196.846993525476 21874.644723021524 0.8896078923682009 0.7562348831907629 1.0053547615370175 0.757153697018643 1.0006564856417446 1.2453719364565805 0.9608359843929762 0.7260955891698518 0.8775844013284543 1.0 14.416971965157396 -5.262745905684825 24.99732115213578 0.9431882947286911 0.8229213886446008 0.11019637380554503 0.14034151228492878 278.46051180592957 5327818.614876231 0.039607242506821884 0.09043709377664257 5.460772631350695e-06 5.262745905684825 -0.1202669060840903 LTEDLEYHELLDR ddPTM_A459_Selumetinib_30min_R1 1 LTEDLEYHELLDR 13 0 P22059;H0YCV6 P22059 OSBP Oxysterol-binding protein 1 0 143.98 0.00097488 4157300.0 2426.3 2669.9 3084.7 2929.7 2688.1 2382.3 2570.9 2882.6 1420.2 2286.1 False True 2482.828069242042 2357.306866797163 2665.8146830442242 2418.0828922801115 2444.9618296226004 2358.336224955333 2376.974943156535 2806.1440839955844 2409.9756726960077 2579.543203499727 0.9625068755869376 0.913846631294622 1.033444479405288 0.9374074018219356 0.9478274394883028 0.9142456779772956 0.9214712666690897 1.0878453519167357 0.9342645121920566 1.0 11.332899894344315 -7.713661144274577 24.999982810919676 1.0082929195768846 0.9476546432784209 0.2520907487100942 0.04744244113500274 151.12456416203662 79075.73945821346 0.021504578406264574 0.012415625691141727 1.9334763122045743e-08 7.713661144274577 -0.060638276298463745 LTEGCS(ph)FR ddPTM_A459_Selumetinib_30min_R1 1 LTEGCSFR 8 0 H0YMV8;Q71UM5;C9J1C5;P42677 H0YMV8;P42677 RPS27L;RPS27 40S ribosomal protein S27;40S ribosomal protein S27-like 1 LTEGCS(1)FR 125.57 0.005056399999999999 31633000.0 4059.2 10909.0 8016.6 10893.0 9132.2 4642.0 4962.7 4051.7 1992.3 4142.5 True False 4153.771462171741 9631.76920854349 6927.989752031745 8990.742036934591 8306.194122420859 4595.305694598773 4588.359543507308 3944.2357542235854 3380.7875881652294 4674.230226367005 0.8886535880797244 2.060610783399447 1.4821669914655553 1.9234700905869901 1.777018614865438 0.9831149669686733 0.9816289145589564 0.8438257345507776 0.7232822142765761 1.0 12.190513079599683 -6.812208780333579 5.90148958131397 0.8932038240068633 1.6589806064353352 0.582896223443782 0.30418456943077893 0.13203543717188188 10.119568554615247 0.10319502633681 0.09208616422759586 1.5409594824974158e-07 6.812208780333579 0.7657767824284719 LTEGCS(ph)FR ddPTM_A459_Selumetinib_30min_R2 3 LTEGCSFR 8 0 H0YMV8;Q71UM5;C9J1C5;P42677 H0YMV8;P42677 RPS27L;RPS27 40S ribosomal protein S27;40S ribosomal protein S27-like 1 LTEGCS(1)FR;LTEGCS(1)FR;LTEGCS(1)FR 99.013 0.018995 91638000.0 167514.0 168963.0 228739.0 198426.0 201617.0 64602.0 86460.0 108171.0 90502.0 159231.0 True False 158204.24249167292 181921.9187983259 214022.18177219317 171400.0364960574 176288.06998115088 73500.33910143258 90480.56131723982 108485.75970132707 108604.92883715955 154633.58729817724 1.0230910713246952 1.1764709205609325 1.3840601224590228 1.1084269562055087 1.1400373816667506 0.47531936874556985 0.5851287737557801 0.7015665975085729 0.7023372524349355 1.0 17.23849418933768 -6.709398945437826 8.630900987884614 0.6678560837638803 1.177391180234596 0.7085956147870014 0.15135329197335656 0.14843244277693776 22.53641804232576 0.04966649597923042 0.04949261750982532 1.9525450125000638e-07 6.709398945437826 0.5095350964707157 LTFDSS(ph)FSPNTGKK ddPTM_A459_Selumetinib_30min_R2 1 LTFDSSFSPNTGKK 14 1 C9JI87;P21796 C9JI87 VDAC1 Voltage-dependent anion-selective channel protein 1 1 LT(0.001)FDS(0.214)S(0.502)FS(0.257)PNT(0.026)GKK 60.618 0.045589 37490000.0 177890.0 58967.0 114310.0 156200.0 75445.0 60435.0 172080.0 110380.0 82754.0 78580.0 True False 168003.58595009186 63489.579291210866 106955.41905131744 134925.2905399708 65966.9246131425 68759.37267569227 180082.060970051 110701.18752560741 99307.11233995197 76311.19122464083 2.2015589490083025 0.8319825476752631 1.4015692499998822 1.7680930984655303 0.8644462699966584 0.9010391735765476 2.359838158467937 1.4506546909971716 1.301344019746946 1.0 16.219607026915185 LTFDSSFS(ph)PNTGK ddPTM_A459_Selumetinib_30min_R1 2 LTFDSSFSPNTGK 13 0 C9JI87;P21796 C9JI87 VDAC1 Voltage-dependent anion-selective channel protein 1 1 LTFDS(0.001)S(0.001)FS(0.998)PNTGK;LTFDS(0.004)S(0.007)FS(0.988)PNT(0.001)GK 240.73 7.8018e-18 45672000.0 4711.4 5712.799999999999 4814.1 3702.2 4168.1 6085.1 4378.7 7871.200000000001 2659.84 5332.4 True False 4821.166453211455 5043.94272019133 4160.37166195844 3055.6802689010583 3791.0960909378227 6023.88941882874 4048.4111336884075 7662.43020673907 4513.554212972643 6016.865481974511 0.8012754261591581 0.8383007290593602 0.6914516660580488 0.5078525152432523 0.6300782529201112 1.00116737475273 0.6728438828849919 1.2734920249911497 0.7501504274101642 1.0 12.554796387705798 -6.761449222434562 24.999999999960657 0.9399560820552482 0.6913600225200537 0.3369048844127026 0.17235919917916123 0.32406035098156066 813482.5347133663 0.05861069054727076 0.055047926754438245 1.7320115251197984e-07 6.761449222434562 -0.24859605953519448 LTFDSSFS(ph)PNTGK ddPTM_A459_Selumetinib_30min_R2 2 LTFDSSFSPNTGK 13 0 C9JI87;P21796 C9JI87 VDAC1 Voltage-dependent anion-selective channel protein 1 1 LTFDS(0.003)S(0.006)FS(0.988)PNT(0.002)GK;LTFDS(0.001)S(0.018)FS(0.896)PNT(0.085)GK 115.09 0.0040713 29742000.0 258930.0 108661.0 175521.0 230120.0 147681.0 128813.0 306910.0 191265.0 192443.0 148010.0 True False 244539.70717891594 116994.94929981629 164228.1699528155 198777.25902085842 129127.99249510898 146555.82150200944 321181.9231306278 191821.5494843745 230936.97730668372 143736.56672383635 1.7013047740924163 0.8139539712577161 1.1425636057409805 1.3829275566514172 0.8983656381831139 1.0196140400625386 2.234517843658534 1.334535489865461 1.6066682443472236 1.0 17.13306760596175 LTFDSSFS(ph)PNTGKK ddPTM_A459_Selumetinib_30min_R1 2 LTFDSSFSPNTGKK 14 1 C9JI87;P21796 C9JI87 VDAC1 Voltage-dependent anion-selective channel protein 1 1 LTFDS(0.001)S(0.027)FS(0.95)PNT(0.021)GKK;LTFDS(0.342)S(0.236)FS(0.419)PNT(0.003)GKK 164.7 0.00046442 61607000.0 4425.5 4231.5 4935.2 4030.0 4007.8 4617.700000000001 3544.0 5331.3 2427.5 3472.4 True False 4528.605539476013 3736.074012829019 4265.026947113124 3326.2361524691446 3645.295197634559 4571.250130536139 3276.6732267092298 5189.896605497002 4119.290202414843 3918.116364040264 1.1558119051896223 0.9535382989433403 1.088540142977054 0.8489375616805859 0.9303693047736901 1.166695857348754 0.8362878797531184 1.3245897067093 1.0513445287692103 1.0 11.93594452946792 -7.755918675528213 24.99999456571921 1.1409753264879914 0.9972547956710228 0.15929947376880005 0.13345368855566117 209.69017089769616 949574.8556526516 0.061451281930515286 0.034189497145204875 1.7542089581466057e-08 7.755918675528213 -0.14372053081696856 LTFDTTFS(ph)PNTGK ddPTM_A459_Selumetinib_30min_R1 1 LTFDTTFSPNTGK 13 0 Q5JSD2;Q5JSD1;A0A0A0MR02;P45880-2;P45880;P45880-1 Q5JSD2 VDAC2 Voltage-dependent anion-selective channel protein 2 1 LTFDT(0.003)T(0.1)FS(0.896)PNT(0.001)GK 95.981 0.014555000000000004 12174000.0 2224.4 2584.1 2377.3 1688.7 1908.5 2763.2 2381.2 4374.3 1447.4 2880.2 True False 2276.2241920710553 2281.5523706845033 2054.4757175741693 1393.8002458249748 1735.8765119730429 2735.404716784864 2201.5841668848807 4258.279354271103 2456.1320860866076 3249.90172552378 0.7003978533240727 0.7020373424728067 0.632165490248187 0.4288745825384424 0.5341320010817482 0.8416884410078598 0.6774309972496341 1.3102794219369218 0.7557558023360715 1.0 11.666180377497602 -7.366874718039406 1.8422716330589475 1.0121216745113653 0.6108876200166253 0.4758834775379849 0.17098317783526948 0.2923727926279738 1.9334659745505016 0.09333002170532928 0.053438358517341966 4.2966035403195297e-08 7.366874718039406 -0.4012340544947399 LTFDTTFS(ph)PNTGK ddPTM_A459_Selumetinib_30min_R2 2 LTFDTTFSPNTGK 13 0 Q5JSD2;Q5JSD1;A0A0A0MR02;P45880-2;P45880;P45880-1 Q5JSD2 VDAC2 Voltage-dependent anion-selective channel protein 2 1 LT(0.018)FDT(0.003)T(0.002)FS(0.929)PNT(0.047)GK;LTFDTT(0.007)FS(0.881)PNT(0.111)GK 143.58 0.00071499 11503700.0 113445.0 38344.0 60021.0 93559.0 38736.0 48001.0 146107.0 80182.0 79371.0 52599.0 True False 107140.18105631683 41284.861504607456 56159.31420592366 80816.1028017227 33869.63737576628 54612.7020403062 152901.26500552823 80415.31634515527 95247.41781103416 51080.330201385535 2.097484112454126 0.8082340372867758 1.0994313072079624 1.58213743887526 0.6630661399844979 1.069153269467801 2.993349189457292 1.5742912394676343 1.8646593989412115 1.0 15.640480230713063 LTFDTTFS(ph)PNTGKK ddPTM_A459_Selumetinib_30min_R1 2 LTFDTTFSPNTGKK 14 1 Q5JSD2;Q5JSD1;A0A0A0MR02;P45880-2;P45880;P45880-1 Q5JSD2 VDAC2 Voltage-dependent anion-selective channel protein 2 1 LTFDT(0.033)T(0.121)FS(0.817)PNT(0.029)GKK;LT(0.026)FDT(0.265)T(0.078)FS(0.627)PNT(0.003)GKK 105.46 0.010476 59909000.0 4583.4 3869.8 5165.9 4147.9 4495.4 5270.9 3799.5 6961.2 2686.5 4032.7 True False 4690.184302256098 3416.722016978787 4464.399154257516 3423.5471307262465 4088.7918637273297 5217.879531594289 3512.9006560050007 6776.566362835659 4558.794285803286 4550.336326824437 1.0307335470143715 0.750872412844971 0.9811141053331999 0.752372326973785 0.8985691540257625 1.146701948344929 0.7720090128934632 1.4892451625800704 1.0018587546878654 1.0 12.15175746714034 -7.135330777052531 1.2635561341306132 1.1413159531709358 0.8759991610635267 0.18804844341484972 0.19002462113512877 0.6392970286464937 2.033742929466251 0.10842954079582813 0.06963537535000527 7.322665954699058e-08 7.135330777052531 -0.2653167921074091 LTFSCLGGSDNFK ddPTM_A459_Selumetinib_30min_R2 1 LTFSCLGGSDNFK 13 0 A0A087WYT3;Q15185-4;Q15185;Q15185-2;Q15185-3 A0A087WYT3 PTGES3 Prostaglandin E synthase 3 0 147.62 0.0078714 2067600.0 13187.0 13585.0 11745.0 14371.0 14642.0 12954.0 13773.0 13667.0 11310.0 11562.0 False True 12454.119331743568 14626.925817340205 10989.33948698911 12413.645008642236 12802.541058859184 14738.295915296056 14413.471790681753 13706.768707306352 13572.316027803545 11228.175018316311 1.1091846458954726 1.3026984165707762 0.9787289091114457 1.1055799351534945 1.14021566621242 1.312617223302429 1.2836878448340292 1.220747689178941 1.2087731092241865 1.0 13.45483583658601 -6.5551110205942305 23.913320816816285 1.2241526768922466 1.1259873940702934 0.10506188459242072 0.10745864478314454 224.09348492729367 166254.2298312024 0.03477946628172276 0.03477981068975048 2.7854090313404656e-07 6.5551110205942305 -0.09816528282195325 LTGS(ph)PGVK ddPTM_A459_Selumetinib_30min_R2 1 LTGSPGVK 8 0 H7C5W6;F5H619;Q86XA9-2;Q86XA9 H7C5W6 HEATR5A HEAT repeat-containing protein 5A 1 LT(0.033)GS(0.967)PGVK 85.53299999999999 0.03514 6189700.0 50256.0 40934.0 52252.0 58361.0 46565.0 46571.0 46108.0 49480.0 35251.0 47691.0 True False 47462.972710707894 44073.50617644487 48890.163207676036 50412.13112165958 40715.08840361824 52985.732520553756 48252.11336126874 49623.97860814504 42302.18499523456 46314.036913900985 1.0248075070403129 0.9516230739803286 1.0556230133547662 1.0884849276986384 0.8791090372732712 1.1440534242146851 1.0418464158278988 1.0714673544955133 0.9133771921863654 1.0 15.499161893054781 -3.531974923853263 17.585574568972643 1.0206447936968055 1.0695980767007411 0.0 0.07799623923447985 0.0 0.0 0.017087516503478336 0.0 0.00029378192766368373 3.531974923853263 0.048953283003935644 LTGS(ph)QLSITQVASIK ddPTM_A459_Selumetinib_30min_R1 1 LTGSQLSITQVASIK 15 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 LT(0.03)GS(0.967)QLS(0.003)ITQVASIK 250.27 4.8515e-28 21773000.0 2077.9 2445.6 2631.2 2759.5 2088.6 1988.9 2263.0 1860.9 1265.1 1637.5 True False 2126.31102711043 2159.2680150714064 2273.8974921470362 2277.605127230424 1899.6864987722788 1968.8934717767124 2092.3000880482477 1811.5428869449045 2146.7823007518086 1847.6890756007183 1.1507948253789002 1.1686316943609074 1.2306710702436499 1.2326777038988186 1.0281418685958594 1.0655978312458163 1.1323875405649633 0.9804370826600997 1.1618742185039166 1.0 10.851506288803044 -6.261537622003534 24.999999977745826 1.0641869021736794 1.1962591914497143 0.5748760097624621 0.05654214613428035 6.565820799927872 1670765.619164263 0.016541116726319714 0.01996265461702952 5.475986616044779e-07 6.261537622003534 0.13207228927603487 LTGS(ph)QLSITQVASIK ddPTM_A459_Selumetinib_30min_R2 1 LTGSQLSITQVASIK 15 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 LT(0.047)GS(0.911)QLS(0.038)IT(0.004)QVASIK 86.016 0.020123 6250100.0 28583.0 29576.0 34452.0 26069.0 29253.0 42378.0 33633.0 26493.0 30890.0 38941.0 True False 26994.47128681479 31844.384098171067 32235.395828501387 22518.357228466673 25577.9766148619 48215.18483081802 35197.00114252518 26570.09024384775 37068.86313871366 37816.67214913122 0.7138246110170999 0.8420726174051422 0.8524122826403154 0.5954611008516253 0.676367727810484 1.2749716485014848 0.9307270878760753 0.7026025489251877 0.9802254146671461 1.0 15.206734791880349 LTGS(ph)TSSLNK ddPTM_A459_Selumetinib_30min_R1 2 LTGSTSSLNK 10 0 Q9NV70-2;Q9NV70 Q9NV70-2 EXOC1 Exocyst complex component 1 1 LTGS(0.692)T(0.233)S(0.06)S(0.015)LNK;LTGS(0.307)T(0.307)S(0.307)S(0.08)LNK 147.62 0.00081756 65792000.0 4221.1 4907.299999999999 5602.5 5228.2 4539.2 4074.8 4651.6 3874.8999999999996 2549.2 4048.1000000000004 True False 4319.443417169181 4332.751034658122 4841.71127232965 4315.193015468781 4128.630161460852 4033.811211622381 4300.726066975357 3772.125064550922 4325.806213798523 4567.713066833142 0.945646837699442 0.9485602469469646 1.0599858619592484 0.944716306022384 0.9038724852135442 0.8831139681063805 0.9415490868293768 0.8258235597023147 0.9470398316411025 1.0 12.1572563114446 -5.997941367612756 24.982656472776853 0.9092396400656908 0.9846534413889856 0.24821211105543395 0.051844965738134456 80.27167015121982 974105.1122217195 0.014145269563795386 0.02082666729232474 1.004751428654688e-06 5.997941367612756 0.07541380132329478 LTGS(ph)TSSLNK ddPTM_A459_Selumetinib_30min_R2 2 LTGSTSSLNK 10 0 Q9NV70-2;Q9NV70 Q9NV70-2 EXOC1 Exocyst complex component 1 1 LTGS(0.555)T(0.249)S(0.061)S(0.135)LNK;LTGS(0.99)T(0.003)S(0.003)S(0.003)LNK 132.32 0.0024598000000000003 29855000.0 91074.0 83691.0 82781.0 93988.0 108148.0 70153.0 83386.0 75068.0 58069.0 80963.0 True False 86012.4716781083 90109.83059102079 77454.96058513786 81186.67226165665 94561.48138461311 79815.93896447166 87263.61422622428 75286.43545182356 69684.42258342388 78625.38782286331 1.093952908339066 1.1460653242694459 0.9851138764445609 1.032575794024237 1.2026838150248942 1.015142070196087 1.1098656126545563 0.9575334066578833 0.886283991888438 1.0 16.262707607709793 -7.823104301609264 5.8832232267191555 0.9379377191491433 1.0821621707215632 0.47493128718858557 0.06527079460011471 0.17300782843834425 11.563429538709679 0.03593733173289726 0.01714575828876908 1.5027810098549434e-08 7.823104301609264 0.14422445157241992 LTGSQLS(ph)ITQVASIK ddPTM_A459_Selumetinib_30min_R1 1 LTGSQLSITQVASIK 15 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 LTGS(0.484)QLS(0.514)IT(0.002)QVASIK 147.75 0.00031792 22672000.0 3546.6 3946.9 4342.3 4567.1 3954.0 3503.5 4193.5 3121.9 1877.0 2896.2 True False 3629.228879517714 3484.795113135972 3752.639510546548 3769.5417200848215 3596.3613981353974 3468.2579709234838 3877.1809187937806 3039.097070639635 3185.13190934404 3267.955481376977 1.1105502814219832 1.0663533004028647 1.1483141468516413 1.1534862520515419 1.1004927755686698 1.061292906432773 1.1864240320556945 0.9299689325507854 0.9746558444553723 1.0 11.674172614769265 -7.769940912820229 24.99996674996126 0.9642342565923504 1.1157954047588108 0.7500001608196333 0.03962971149166036 91.34139640481595 268597.6000462662 0.021041927268625308 0.010362796582547702 1.698474719764167e-08 7.769940912820229 0.15156114816646038 LTGST(ph)SSLNK ddPTM_A459_Selumetinib_30min_R1 2 LTGSTSSLNK 10 0 Q9NV70-2;Q9NV70 Q9NV70-2 EXOC1 Exocyst complex component 1 1 LTGS(0.114)T(0.388)S(0.186)S(0.313)LNK;LTGS(0.006)T(0.419)S(0.419)S(0.155)LNK 183.85 0.00039545 31096600.0 8268.099999999999 8653.400000000001 9650.3 10114.7 8703.5 7657.200000000001 8128.700000000001 8026.8 4653.8 7417.700000000001 True False 8460.73064307799 7640.255905143478 8339.84226530349 8348.357521434164 7916.269961727726 7580.175520181332 7515.545614546086 7813.903189279037 7897.158699896272 8369.83404951661 1.0108600233915783 0.9128324241488076 0.9964166811389944 0.9974340556867209 0.9458096677776927 0.9056542191083365 0.8979324524337656 0.9335792254722565 0.9435263176278105 1.0 13.03098330309925 -6.4844195584960245 7.027406202866349 0.9291439191268714 0.9754976257372544 0.23399648009153318 0.035875924497172966 0.307487907446658 45.45265923940667 0.011075676756521317 0.01232623335108864 3.277784834305956e-07 6.4844195584960245 0.04635370661038296 LTGSTS(ph)SLNK ddPTM_A459_Selumetinib_30min_R2 1 LTGSTSSLNK 10 0 Q9NV70-2;Q9NV70 Q9NV70-2 EXOC1 Exocyst complex component 1 1 LTGS(0.193)T(0.193)S(0.507)S(0.107)LNK 116.84 0.006211 17053000.0 35718.0 33801.0 38958.0 44678.0 40276.0 27591.0 35766.0 30420.0 26184.0 32001.0 True False 33732.936550482824 36393.42801265483 36451.484694263236 38592.77932615114 35216.16880799158 31391.409803839255 37429.18986898448 30508.517163697903 31421.53164208733 31077.04798141673 1.0854614173989192 1.1710709470995173 1.1729391001378342 1.2418418682890544 1.1331889962344537 1.010115562540255 1.2043997837685925 0.98170576503731 1.0110848257169276 1.0 14.923561847746821 -7.601081501092728 0.8570923164605972 0.9857876051506096 1.1626304355535837 0.45516982339852985 0.06711153987495988 0.5520315739227852 0.7482799769196112 0.059243563161328026 0.027893595746925567 2.50563899267385e-08 7.601081501092728 0.1768428304029741 LTGSTSS(ph)LNK ddPTM_A459_Selumetinib_30min_R1 1 LTGSTSSLNK 10 0 Q9NV70-2;Q9NV70 Q9NV70-2 EXOC1 Exocyst complex component 1 1 LTGS(0.073)T(0.249)S(0.249)S(0.429)LNK 174.57 7.9616e-05 24684000.0 4008.0 3435.8 4676.5 4494.9 4063.4 3138.7 3756.2 3537.7 1832.9 3327.9 True False 4101.378601789598 3033.534938739916 4041.4569861757427 3709.9500947229676 3695.8661874515387 3107.127527711582 3472.8668098660323 3443.8687039308893 3110.297430280605 3755.0683814910694 1.092224744030098 0.8078507847399984 1.0762672142260572 0.9879846963665183 0.984234057006434 0.8274489868218586 0.9248478208769716 0.917125429967108 0.8282931532249653 1.0 11.874623464769087 -6.723115092507782 23.46499617696 0.8959449907529319 0.9843217073634047 0.21688956946013038 0.08522462086930817 134.26078791970707 82203.52284863591 0.026633104547371285 0.02663226106727591 1.8918421945528527e-07 6.723115092507782 0.08837671661047286 LTGSTSS(ph)LNK ddPTM_A459_Selumetinib_30min_R2 1 LTGSTSSLNK 10 0 Q9NV70-2;Q9NV70 Q9NV70-2 EXOC1 Exocyst complex component 1 1 LTGS(0.006)T(0.299)S(0.185)S(0.51)LNK 123.67 0.004080599999999999 4461500.0 32185.0 22073.0 33725.0 31830.0 26287.0 21879.0 24685.0 23891.0 17326.0 23130.0 True False 30396.286546763244 23765.928124118516 31555.170217003637 27494.699090187347 22984.592051238327 24892.63365221266 25832.901412399533 23960.518854632042 20791.684128888064 22462.176801042748 1.3532208750735226 1.0580420737768943 1.4048135448537102 1.2240442826944082 1.0232575522320404 1.1082021957487702 1.1500622420174482 1.0667051135275427 0.9256308644103837 1.0 14.455210125092686 -6.748015608802687 0.505567283010374 0.980385964520089 1.285894478949413 0.4865130541356112 0.10489942344794514 0.995487328971103 0.5425339834452945 0.09604288760101407 0.12842524440526779 1.786423368576986e-07 6.748015608802687 0.3055085144293239 LTIFGNSAVSQPAS(ph)SSNHSSR ddPTM_A459_Selumetinib_30min_R1 1 LTIFGNSAVSQPASSSNHSSR 21 0 P46934-3;P46934-2;P46934;H0Y8X6;P46934-4 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 LTIFGNSAVS(0.002)QPAS(0.329)S(0.329)S(0.125)NHS(0.125)S(0.09)R 68.024 0.005331 10494000.0 2277.0 2090.7 2743.9 2626.2 3119.5 2052.6 2766.6 1899.4 1237.4 1554.6 True False 2330.049669729271 1845.9198720599397 2371.2934511638236 2167.5834698795225 2837.3417757924576 2031.952707611686 2557.9131345975625 1849.0217418792802 2099.7774238797647 1754.1480530863364 1.3283084433093686 1.0523170315140364 1.3518205872028022 1.2356901494521897 1.6175041615217687 1.1583701296116746 1.4582082339612334 1.0540853371105239 1.1970354612800844 1.0 10.776554803504757 -7.781042266523489 24.999918126396818 1.0941701935275872 1.3085522583039366 0.3218300388068144 0.1531949279374757 322.4501422135225 411220.5747712027 0.08172472977688365 0.03934615831441827 1.655608828024349e-08 7.781042266523489 0.21438206477634947 LTIFGNSAVSQPASSSNHS(ph)SR ddPTM_A459_Selumetinib_30min_R2 2 LTIFGNSAVSQPASSSNHSSR 21 0 P46934-3;P46934-2;P46934;H0Y8X6;P46934-4 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 LTIFGNSAVSQPASS(0.012)S(0.012)NHS(0.64)S(0.336)R;LTIFGNSAVSQPAS(0.009)S(0.009)S(0.009)NHS(0.487)S(0.487)R 175.34 1.6759e-12 9226000.0 29242.0 22501.6 43690.0 74938.0 84581.0 42741.0 36270.0 42293.0 41280.0 47247.0 True False 27616.846705000797 24227.40036595232 40879.03296607529 64731.31512473953 73955.17861626609 48628.18478583213 37956.62686764153 42416.06562801692 49537.153459569396 45882.8563475515 0.6018990294721386 0.5280272915538572 0.8909435074491994 1.4107952354669364 1.6118259520739853 1.0598334248741061 0.8272507400177812 0.9244425697198431 1.0796440632278315 1.0 15.485667585859106 -5.460821660795713 4.16986067027444 1.1338541102037916 0.5766210789521748 0.5140882788644131 0.2183596194021517 0.19873638701572602 6.819052382905946 0.06784751546781255 0.14489868805627182 3.460814639562497e-06 5.460821660795713 -0.5572330312516167 LTLEDLEDSWDR ddPTM_A459_Selumetinib_30min_R2 1 LTLEDLEDSWDR 12 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 136.02 0.019967 1207800.0 7427.5 7703.0 6648.3 8062.8 8838.5 5392.2 5656.4 7082.5 5451.7 7835.3 False True 7014.709284638307 8293.795330951161 6220.55561612173 6964.632730894206 7728.128612807466 6134.926604481967 5919.433807943965 7103.1089024290095 6542.19233322516 7609.0745304457505 0.9218873144915003 1.0899873956767905 0.8175180294570358 0.9153061522826493 1.0156463288518665 0.80626449115916 0.7779439909885068 0.9335049714663393 0.8597881788446498 1.0 12.893505278268758 -6.764081864556737 24.999894058456544 0.8652471231803497 0.9502137324210637 0.15423618824028262 0.08797457522870585 125.87395952350795 1190849.3282109818 0.03030403587975258 0.027944588513193362 1.7215440331627265e-07 6.764081864556737 0.08496660924071398 LTLEGLEEDDDDRVS(ph)PTVLHK ddPTM_A459_Selumetinib_30min_R1 1 LTLEGLEEDDDDRVSPTVLHK 21 1 Q9NPB8 Q9NPB8 GPCPD1 Glycerophosphocholine phosphodiesterase GPCPD1 1 LTLEGLEEDDDDRVS(0.946)PT(0.054)VLHK 85.20299999999997 0.00047942 4733500.0 2918.4 4139.0 3355.8 3209.1 2439.6 3139.2 2571.3 3389.1 2294.4 3583.5 True False 2986.393041782128 3654.403955831104 2900.1007920899315 2648.6909272676767 2218.9386107463624 3107.6224981655455 2377.344770834493 3299.210058651714 3893.429223654217 4043.477131245909 0.7385705284950966 0.9037775748975436 0.7172294285231505 0.6550527779172923 0.548769917257488 0.7685520153314184 0.5879456452130264 0.8159338983661161 0.9628913673253648 1.0 11.981380736668358 -8.137516903577197 3.075817566819514 0.9878555462279832 0.7055539082938189 0.5812717740526698 0.09359093772039992 0.20256014304039613 3.4184738696540675 0.08267868706906276 0.026538873628135028 7.285898158432697e-09 8.137516903577197 -0.2823016379341643 LTLEGLEEDDDDRVS(ph)PTVLHK ddPTM_A459_Selumetinib_30min_R2 1 LTLEGLEEDDDDRVSPTVLHK 21 1 Q9NPB8 Q9NPB8 GPCPD1 Glycerophosphocholine phosphodiesterase GPCPD1 1 LTLEGLEEDDDDRVS(0.5)PT(0.5)VLHK 95.094 0.00018265 2119500.0 16145.0 13945.0 16135.0 16129.0 16876.0 16270.0 13971.0 13727.0 10225.0 14531.0 True False 15247.725533555775 15014.536659757745 15096.89166645971 13932.202375923074 14755.886006645793 18511.044815645113 14620.679183011312 13766.94329737282 12270.285710370568 14111.452273927893 1.0805213551072446 1.063996558844505 1.0698325993244864 0.9872975584280579 1.045667428143349 1.3117746108843695 1.0360860738638686 0.9755865682803192 0.8695267837911314 1.0 13.784578849453258 -7.743429378874222 3.53997804939896 0.9358266434648096 1.0893178633274414 0.36109775918098364 0.08550866539932615 0.26078629191671115 6.851364648425205 0.05046302698730613 0.024709721405692647 1.805388289532082e-08 7.743429378874222 0.1534912198626318 LTLNS(ph)PIFDKPLSR ddPTM_A459_Selumetinib_30min_R1 2 LTLNSPIFDKPLSR 14 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;H0YBX5;E5RIU4 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 LTLNS(1)PIFDKPLSR;LT(0.101)LNS(0.899)PIFDKPLSR 97.352 0.0061348 283190000.0 8568.3 9339.9 10025.3 10475.0 8787.400000000001 7428.0 8648.400000000001 7719.200000000001 4815.700000000001 6502.9 True False 8767.924718990478 8246.380165998286 8663.919325031049 8645.73789010281 7992.581221541478 7353.2810640843845 7996.044225133219 7514.461740504654 8171.891175188119 7337.6105586100175 1.1949291460695086 1.1238508912580416 1.1807548596136284 1.1782770182532818 1.0892621184648335 1.002135641480179 1.0897340709572805 1.0241020125669 1.113699222643964 1.0 12.84109462069149 -6.411409919472583 3.957260413792855 1.0496913405195754 1.1665936382559796 0.7030110373188503 0.037746301688259376 0.13127846436897095 3.588390569750179 0.011458508292109414 0.012963174742471795 3.877841736178745e-07 6.411409919472583 0.11690229773640426 LTLNS(ph)PIFDKPLSR ddPTM_A459_Selumetinib_30min_R2 3 LTLNSPIFDKPLSR 14 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;H0YBX5;E5RIU4 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 LT(0.004)LNS(0.996)PIFDKPLSR;LT(0.019)LNS(0.981)PIFDKPLSR;LT(0.059)LNS(0.941)PIFDKPLSR 89.374 0.010779 37123600.0 95483.0 100131.0 104398.0 120078.0 121046.0 102641.0 106068.0 100815.0 86507.0 113835.0 True False 90176.4371087336 107810.72572808914 97681.14633994794 103723.1692538961 105839.11931503014 116778.86606777084 111000.3721697546 101108.35495917837 103810.81720753346 110548.28777114996 0.8157198897138157 0.9752365043524875 0.883606144512715 0.938261201011247 0.9574017060683161 1.0563606946994877 1.004089474452472 0.9146080594978229 0.939054048692604 1.0 16.754317154559736 -6.098293251069089 2.404265428041096 0.9801074627771362 0.8997836214024899 0.36447154470812226 0.05126618291882203 0.37496255404260526 4.259461401787772 0.01690841433676446 0.024094901180332876 7.974560347733716e-07 6.098293251069089 -0.08032384137464632 LTLYDIAHTPGVAADLSHIETK ddPTM_A459_Selumetinib_30min_R1 2 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 ; 130.01 1.4048e-05 28100000.0 12023.7 13986.0 15089.0 16407.6 14068.8 13995.6 12547.9 12880.7 7141.4 10000.099999999999 False True 12303.828815952498 12348.512618085004 13039.99667794415 13542.320668797218 12796.279524048377 13854.816970988071 11601.40180062776 12539.061993589794 12118.434212780783 11283.710244222739 1.0904063069372116 1.0943663343719274 1.1556479558326687 1.2001655816827526 1.1340489295708451 1.2278600452436945 1.0281548843003727 1.1112534549537725 1.0739760194556063 1.0 13.461953903918593 -8.28668286823888 0.8434530773885104 1.006099150401698 1.1442829886326364 0.41731139670526096 0.0514244144077355 0.5917925695963135 0.9106833321317557 0.05041381480216592 0.01884896230985955 5.167936060298093e-09 8.28668286823888 0.13818383823093838 LTNSMMMHGR ddPTM_A459_Selumetinib_30min_R2 1 LTNSMMMHGR 10 0 M0R0F0;M0R0R2;P46782 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 128.51 0.0043625 3294300.0 24496.0 17837.0 33955.0 34996.0 39137.0 24677.0 22305.0 27064.0 22921.0 30582.0 False True 23134.610385257492 19205.040545005308 31770.372267408697 30229.484428532716 34220.26017078079 28076.032754497526 23342.22669651901 27142.751759313618 27505.84046624977 29699.018198421483 0.778968861215995 0.6466557384723939 1.069744866821803 1.0178614062783875 1.152235401929873 0.9453522189494392 0.7859595404995462 0.9139275776044431 0.9261531907378581 1.0 14.858127618195665 -5.257362770280726 24.99807923094237 0.9731799566875582 0.7128122852318916 0.5405933143372119 0.09716121390632446 285.13437158363917 1748449.4281946078 0.027772609606745966 0.06812139605437945 5.5288808363958965e-06 5.257362770280726 -0.26036767145566664 LTPEEEEILNK ddPTM_A459_Selumetinib_30min_R1 1 LTPEEEEILNK 11 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 134.84 0.021491 7071400.0 1497.3 1348.9 1430.6 1746.2 1381.9 1327.0 1367.0 1478.2 1175.7 1176.8 False True 1532.184176761368 1190.9701609134036 1236.3323777233022 1441.2589502336534 1256.9073889942608 1313.6515848195975 1263.8860894219868 1438.9933341296992 1995.0770302694664 1327.8537430027018 1.1538802257668903 0.8969136602501412 0.9310757184202829 1.0854048932938247 0.9465706563073667 0.9893044258391074 0.9518262806293232 1.0836986691589054 1.5024825141946427 1.0 10.374880533858336 -8.01258145844664 23.19896098826695 1.2651911122291242 0.9910614437301402 0.3683568643202362 0.13342720343172654 200.4358331176507 369578.9843309172 0.075278359078071 0.03157391363970452 9.714457252657512e-09 8.01258145844664 -0.274129668498984 LTPEEEEILNK ddPTM_A459_Selumetinib_30min_R2 1 LTPEEEEILNK 11 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 152.54 0.0079846 4657500.0 17950.0 17077.0 15821.0 23596.0 19617.0 11104.0 13889.0 15215.0 15391.0 15575.0 False True 16952.410859543274 18386.750988790478 14803.094084602357 20382.184094629603 17152.537081794886 12633.475207923997 14534.86602053138 15259.273131021164 18469.63006047077 15125.309281290125 1.1207976342350405 1.215628100347986 0.9786969515336559 1.3475548642064588 1.1340288494472257 0.8352540085611007 0.9609632272783263 1.008856932922142 1.2211075963463134 1.0 13.884677022367859 -6.5474253747752895 24.954086680881904 1.0009803977804888 1.1664963764376612 0.28579223361303097 0.12253109641045878 288.8245873385939 293616.75129340746 0.040595829679936 0.0405973118610341 2.835140756509882e-07 6.5474253747752895 0.1655159786571725 LTPEELER ddPTM_A459_Selumetinib_30min_R2 1 LTPEELER 8 0 Q5H8X8;O95399;O95399-2 Q5H8X8 UTS2 Urotensin-2 0 153.04 0.012693 8460100.0 38089.0 32801.0 49725.0 41796.0 45016.0 30505.0 33998.0 29469.0 25544.0 36781.0 False True 35972.165862347836 35316.731228161654 46525.74763648649 36103.31269787841 39360.68763185392 34706.786853181 35578.97436575895 29554.74991114444 30653.513758993246 35719.03696148521 1.007086666450038 0.9887369378475307 1.302547649497209 1.0107582893908242 1.101952655506793 0.9716607670751122 0.996078768980326 0.8274229213685818 0.8581842167818251 1.0 15.124405563322721 -7.1561018465979025 1.4906078769727054 0.8897716848399596 1.086682338133961 0.3865772705726801 0.0967260819955694 0.4021842447996453 1.7666362519953438 0.05365703293319479 0.03487297003911918 6.980686804744281e-08 7.1561018465979025 0.19691065329400137 LTPIVHS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 1 LTPIVHSPLR 10 0 Q96KQ4;A0A3B3ISJ2;H0YJL1 Q96KQ4 PPP1R13B Apoptosis-stimulating of p53 protein 1 1 LTPIVHS(1)PLR 106.55 0.0078269 1848900.0 9901.4 9425.4 10414.0 13162.0 11955.0 8212.0 9891.6 10665.0 7588.4 12010.0 True False 9351.119826444667 10148.297872562256 9743.974577905883 11369.312894283566 10453.106020943967 9343.12845888616 10351.57899983356 10696.033384314205 9106.29203761135 11663.240094272522 0.8017600384507844 0.8701096599688272 0.8354431958140744 0.9747988382633661 0.8962437484312086 0.8010748628483005 0.8875388756608826 0.9170722113117363 0.7807686341022154 1.0 13.50968101016213 -12.127185427815416 2.2095494574844325 3.8793000574692886 0.8669621073498189 0.34105254811934216 0.056961135181960144 1732762.9903020437 297975.38251855166 24681298.165072642 0.01439207466809627 7.461301201955326e-13 12.127185427815416 -3.01233795011947 LTPRPS(ph)PSPMIESTPMSIAGDATPLLDEMDR ddPTM_A459_Selumetinib_30min_R2 2 LTPRPSPSPMIESTPMSIAGDATPLLDEMDR 31 1 Q7KZ85;Q7KZ85-3;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 LT(0.009)PRPS(0.358)PS(0.358)PMIES(0.091)T(0.091)PMS(0.091)IAGDATPLLDEMDR;LT(0.224)PRPS(0.542)PS(0.187)PMIES(0.024)T(0.012)PMS(0.011)IAGDATPLLDEMDR 60.64100000000001 0.00090773 27573000.0 9017.900000000001 10890.1 13959.5 12983.5 11349.5 10846.7 10566.4 6701.3 5596.8 11287.8 True False 8516.721219513945 11725.33565280946 13061.360967954415 11215.124902213236 9923.674344182655 12340.734468460842 11057.758536924395 6720.7996735400675 6716.316387657897 10961.891884773471 0.776938990918532 1.0696452561347045 1.191524337700976 1.0231012146536052 0.9052884710500617 1.1257850924075106 1.0087454476981375 0.6131058164216654 0.612696828089241 1.0 13.420209190369413 -7.748124372975533 24.23616900094814 0.709676037693299 1.0237858971188254 0.4101757774830672 0.14794039772054302 127.86930015842718 232750.86046715526 0.06888082671967054 0.03944695136207564 1.785976034935462e-08 7.748124372975533 0.3141098594255264 LTPS(ph)PDIIVLSDNEASSPR ddPTM_A459_Selumetinib_30min_R1 2 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LT(0.001)PS(0.999)PDIIVLSDNEASSPR;LT(0.004)PS(0.995)PDIIVLSDNEASSPR 203.93 8.493600000000001e-16 9713500.0 2479.66 2615.0 3188.6000000000004 3396.6000000000004 3087.5 2202.0 2819.1 2537.7 1618.8400000000001 2243.1 True False 2537.431253421556 2308.8345843194816 2755.605633726074 2803.4475720785845 2808.2361701423997 2179.8498792560326 2606.4530173295693 2470.391952388675 2747.053244604427 2531.023734644257 1.002531591738787 0.9122137231336535 1.08873164483121 1.1076338533319277 1.1095258142796933 0.8612522472304738 1.029801886743632 0.9760445619589956 1.0853526211560929 1.0 11.3055053210293 LTPS(ph)PDIIVLSDNEASSPR ddPTM_A459_Selumetinib_30min_R2 2 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LTPS(1)PDIIVLSDNEASSPR;LT(0.034)PS(0.965)PDIIVLSDNEASSPR 276.62 1.0674999999999999e-60 4874800.0 23677.2 22970.1 30035.0 32350.0 31419.0 24655.9 23409.3 26051.0 23476.3 31807.5 True False 22361.316011341398 24731.832809487376 28102.580799635423 27943.874193137326 27471.8643305762 28052.026421024268 24497.878834647952 26126.804097024782 28172.21598262814 30889.134829190094 0.7239217328356524 0.80066447138286 0.9097885374594115 0.9046505947045979 0.8893698215404665 0.9081518979455271 0.7930904821425289 0.845825052773413 0.9120428959378144 1.0 14.914811842774085 -8.13767115357072 0.022190444622126305 1.7900774604542418 3.636774489280426e-06 0.45388769241134785 0.05525794619079099 242.87019464729838 5.131699665648575 208.2292541958241 204.11566376285373 7.283310858263712e-09 8.13767115357072 -1.7900738236797524 LTPSPDIIVLS(ph)DNEASSPR ddPTM_A459_Selumetinib_30min_R1 4 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LTPSPDIIVLS(1)DNEASSPR;LTPSPDIIVLS(1)DNEASSPR;LTPSPDIIVLS(0.648)DNEAS(0.176)S(0.176)PR;LTPSPDIIVLS(0.636)DNEAS(0.03)S(0.334)PR 222.96 1.5895999999999999e-19 41483500.0 7268.340000000001 8338.47 8755.279999999999 9526.699999999999 9127.630000000001 7447.879999999999 7849.12 7157.870000000001 4542.66 6809.790000000001 True False 7437.67818027231 7362.1980559504655 7566.361065310545 7863.040683307144 8302.03747811396 7372.961089333977 7257.054559037237 6968.020035561468 7708.5622372407 7683.892879471764 0.9679570364837803 0.9581338745129131 0.9847041316159917 1.023314719068246 1.080446800643672 0.9595346011435857 0.9444502510472438 0.9068346142847961 1.0032105285895958 1.0 12.907621691311013 -9.235848329431729 10.380865269946703 1.000000000110096 0.9806817253981588 0.015889995138727908 0.04491993853920855 2782795.789247767 112538.67976884166 0.0479913059779581 0.011997826492806623 5.809672758486261e-10 9.235848329431729 -0.019318274711937145 LTPSPDIIVLS(ph)DNEASSPR ddPTM_A459_Selumetinib_30min_R2 2 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LTPS(0.011)PDIIVLS(0.989)DNEASSPR;LTPSPDIIVLS(1)DNEASSPR 156.83 3.054800000000001e-06 4163500.0 9491.1 10176.599999999999 9954.0 13993.6 13966.0 8312.3 10249.6 8890.3 10633.0 14222.7 True False 8963.622657883625 10957.112497073553 9313.570477095756 12087.647539693551 12211.466222375871 9457.24387345341 10726.226709197103 8916.169301131606 12759.897110843067 13812.053695987495 0.6489710259733225 0.7933007457288321 0.6743074333544923 0.8751520813450865 0.8841166195236696 0.6847094633146995 0.7765844924504711 0.6455353778216066 0.9238233062002874 1.0 13.753640227511386 -8.45592467071069 5.448545454196601 0.9992005716526682 0.7550874824865944 0.526897250475285 0.0824053554411841 0.15032981467148349 8.042765784648878 0.0796893535636044 0.020696233330383635 3.5000587101644893e-09 8.45592467071069 -0.24411308916607377 LTPSPDIIVLSDNEAS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LTPSPDIIVLS(0.111)DNEAS(0.666)S(0.223)PR 108.47 0.00073761 3066400.0 671.4 706.33 737.43 874.15 746.35 795.63 923.95 933.88 466.96 682.68 True False 687.042313683018 623.6325552360919 637.2910564130395 721.4961123277681 678.842774278795 787.6266845742406 854.2557076235872 909.1104687302418 792.3970145909922 770.3086278663197 0.8919052556714296 0.8095879140851553 0.8273191203612428 0.9366325213391967 0.8812607696724412 1.0224819716168703 1.1089785012402014 1.1801899081000686 1.0286747232545677 1.0 9.589292774132062 -6.838576377428719 2.1926173782170344 1.0949113013900122 0.861047133429013 0.7603275327984405 0.05619366006111184 0.140031536847319 1.3792322370087262 0.022694164267942758 0.019880819860118137 1.4501857142000125e-07 6.838576377428719 -0.2338641679609993 LTPSPDIIVLSDNEAS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LTPSPDIIVLS(0.001)DNEAS(0.946)S(0.054)PR 188.9 2.6805e-15 2448900.0 17289.0 14706.0 19778.0 18902.0 23695.0 16310.0 16454.0 14616.0 13922.0 17019.0 True False 16328.146593350612 15833.902912757078 18505.505012658203 16327.51499223127 20718.222264012336 18556.554452561282 17219.143602982458 14658.530140190944 16706.78901318134 16527.617249327563 0.987931069980153 0.9580269602021 1.1196716824629462 0.9878928550874789 1.2535516736301036 1.1227604180703221 1.0418406563525078 0.8869112781993627 1.0108407498280532 1.0 14.012591128961207 -7.561336850238033 10.347012910410818 0.9620062902202431 1.0738881662621627 0.23054890868055378 0.08627823300236517 0.7061072651312116 184.13739587014558 0.04264944436819195 0.02463534814713686 2.7457636403745815e-08 7.561336850238033 0.11188187604191957 LTPSPDIIVLSDNEASS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LTPSPDIIVLSDNEASSPR 19 0 A0A0U1RRM1;Q8WXI9;A0A0U1RRK3;A0A0U1RR34 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 LTPSPDIIVLS(0.269)DNEAS(0.086)S(0.645)PR 130.01 0.00029622 3326100.0 15248.0 14940.0 17767.0 18522.0 20756.0 13102.0 12393.0 13489.0 12379.0 15179.0 True False 14400.577202580258 16085.84996032849 16623.890563246965 15999.271647767833 18148.445719005696 14906.681571885825 12969.299056263633 13528.250756775837 14855.14589815915 14740.742830221701 0.9769234405918791 1.0912509732785671 1.1277512100112352 1.0853775709977027 1.2311757913446173 1.011257149220724 0.8798266956854965 0.917745524264897 1.007761011046397 1.0 13.847521607542411 -6.994212560148082 24.989652225011195 0.9446306371993755 1.1042124999010978 0.529705396339986 0.0673591709859583 114.57469694147974 494719.9812645397 0.023941019189410384 0.02105250195313184 1.0134152605710332e-07 6.994212560148082 0.15958186270172237 LTPVRPAAAS(ph)PIVSGAR ddPTM_A459_Selumetinib_30min_R2 2 LTPVRPAAASPIVSGAR 17 1 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 LTPVRPAAAS(0.999)PIVS(0.001)GAR;LTPVRPAAAS(0.999)PIVS(0.001)GAR 119.37 0.00082933 9956800.0 27331.0 21914.0 23305.0 24170.0 24362.0 23965.0 18338.5 22394.0 20921.0 23774.0 True False 25812.052434661673 23594.733335384124 21805.581672565455 20878.00430442439 21301.427760956674 27265.961217390013 19191.27658704837 22459.162832473732 25105.784581580723 23087.58284772981 1.1180058391084349 1.0219663743493261 0.9444722653029738 0.9042958044643168 0.9226356826284755 1.180979464035624 0.8312380171463224 0.9727810390805866 1.0874150294191305 1.0 14.494829517748803 -4.844600085968748 3.1332196271914228 0.9767189734523931 1.1295146085397176 0.16800049761320024 0.09222359223958072 0.542173859939501 8.573383232296873 0.023410194901174006 0.19009264814814944 1.4302103416258868e-05 4.844600085968748 0.15279563508732452 LTPVS(ph)LSNSPIKGADCQEVPQDKDGYK ddPTM_A459_Selumetinib_30min_R1 1 LTPVSLSNSPIKGADCQEVPQDKDGYK 27 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LT(0.025)PVS(0.371)LS(0.329)NS(0.274)PIKGADCQEVPQDKDGYK 52.79 0.0065179 263560000.0 1772.6 1754.3 2969.0 2665.8 1859.3 1893.0 1983.2 1538.8 1160.7 1520.7 True False 1813.8981311208202 1548.9057404480561 2565.8261075496184 2200.2680732635854 1691.126643286077 1873.9581387064802 1833.6056273165195 1497.9860252731569 1969.623125826121 1715.896657872374 1.0571138551956638 0.902680084690311 1.4953267120008933 1.282284724531026 0.9855643902139127 1.0921159675374008 1.0685991017606498 0.8730048038735531 1.1478681520764515 1.0 10.74474695191414 -6.273997676702098 24.661312703764654 1.0267588519430464 1.1864444975529984 0.19116212460023596 0.15766584673892 1164.4394147017965 2286659.628648937 0.05171796357533511 0.05904797753329826 5.321111058360241e-07 6.273997676702098 0.15968564560995202 LTPVS(ph)LSNSPIKGADCQEVPQDKDGYK ddPTM_A459_Selumetinib_30min_R2 1 LTPVSLSNSPIKGADCQEVPQDKDGYK 27 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LT(0.056)PVS(0.326)LS(0.309)NS(0.309)PIKGADCQEVPQDKDGYK 41.661 0.032894 12643000.0 23020.0 23950.0 24525.0 25030.0 25750.0 18406.0 12986.0 23540.0 18097.0 24709.0 True False 21740.64055636135 25786.88798861228 22947.088200801034 21620.870820841625 22515.054792079238 20941.259426967696 13589.87473127083 23608.497502743212 21716.905672427998 23995.586968308042 0.9060266200228863 1.0746512691133618 0.9563045167891995 0.9010352965900438 0.9382998141206462 0.8727129473692674 0.5663489186248928 0.9838683060316018 0.9050374846470898 1.0 14.550481483535412 -6.105617185212609 1.4100239933370535 0.853651566039661 0.9898505355109516 0.1200424756632521 0.11984320146232073 0.77446397319023 3.1045126377449175 0.044912500386940814 0.0723574835554734 7.84120511940642e-07 6.105617185212609 0.13619896947129062 LTPVS(ph)PES(ph)SSTEEK ddPTM_A459_Selumetinib_30min_R1 1 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 LTPVS(0.999)PES(0.547)S(0.346)S(0.064)T(0.044)EEK 140.27 0.01026 4406400.0 1683.1 1812.6 1399.5 1421.2 1135.3 1455.1 1171.0 1434.5 710.6 1422.5 True False 1722.3129552575042 1600.379949345121 1209.4555869032304 1173.0140992280762 1032.6123154534948 1440.4630151250922 1082.6705272224917 1396.4524000873043 1205.836299829448 1605.0917313233706 1.0730308565215065 0.9970644780691975 0.7535118169888365 0.7308081378382943 0.6433353903095144 0.8974334531880338 0.6745225248465073 0.8700140763518565 0.7512569383403755 1.0 10.648440034684812 -5.166406036852036 3.9031557794399347 0.7776385891371701 1.0562271080936327 0.4779560316092972 0.10271620222265039 0.17472112356619823 4.767877489284461 0.025034455492433983 0.07628131091713958 6.817010503462273e-06 5.166406036852036 0.27858851895646264 LTPVS(ph)PESS(ph)STEEK ddPTM_A459_Selumetinib_30min_R1 1 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 LTPVS(1)PES(0.005)S(0.586)S(0.38)T(0.03)EEK 160.79 0.00042767 0.0 1986.3 2705.9 2081.7 2065.4 1707.4 2272.6 1934.3 2004.5 1061.5 1799.6 True False 2032.5769253330047 2389.091970061218 1799.0165739595943 1704.7166623597443 1552.9659714659533 2249.7397073557036 1788.394193686135 1951.3341484663667 1801.2879711074586 2030.5961895884288 1.0009754454158497 1.176547056628453 0.8859548654645254 0.8395153458380441 0.764783258940674 1.1079207766127503 0.8807237021599137 0.9609661233836319 0.887073451798682 1.0 10.987687654182553 -5.274213661876533 24.80602337354749 0.9119543434709403 1.0887612533899191 0.33869046109139966 0.09651262232062516 658.1548484678016 1278053.3144793452 0.025129418600208838 0.052854650733104136 5.318465398761293e-06 5.274213661876533 0.17680690991897885 LTPVS(ph)PESSS(ph)TEEK ddPTM_A459_Selumetinib_30min_R2 1 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 LT(0.031)PVS(0.966)PES(0.009)S(0.157)S(0.724)T(0.112)EEK 135.72 0.010938 4175900.0 31119.0 27680.0 26757.0 28781.0 26704.0 23817.0 26317.0 28486.0 20991.0 22063.0 True False 29389.530559227132 29802.966994771938 25035.483750818865 24860.978150005714 23349.204783211026 27097.57556080026 27540.792646146205 28568.889543888818 25189.786537544147 21425.98386344169 1.3716770602713526 1.3909730906510933 1.1684636705778504 1.1603190923906659 1.0897611485207386 1.2647062432934892 1.2853922051690692 1.3333758545685637 1.1756653369147956 1.0 14.387073832770238 -5.257458044918403 24.844581911079413 1.1988073267185362 1.381325098312249 0.4163188331362945 0.09191709589360186 321.69975189046045 2007471.1083511394 0.02430979078563317 0.059540618732441423 5.527668054828044e-06 5.257458044918403 0.18251777159371274 LTPVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R1 5 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LTPVS(0.995)PES(0.003)S(0.001)S(0.001)TEEK;LTPVS(1)PESSSTEEK;LTPVS(0.911)PES(0.078)S(0.009)S(0.002)TEEK;LT(0.002)PVS(0.909)PES(0.082)S(0.008)STEEK;LT(0.009)PVS(0.961)PES(0.012)S(0.012)S(0.004)T(0.001)EEK 254.94 4.327e-28 3192772000.0 16291.8 17319.399999999998 14678.300000000001 14865.8 12655.2 13811.0 13477.900000000001 13758.800000000001 7934.92 11544.4 True False 16671.367241675605 15291.636596429385 12685.067482130538 12269.767095626761 11510.539394457033 13672.073879384672 12461.251151880466 13393.87192911901 13464.979696373046 13026.236191978574 1.279829952104021 1.173910588681466 0.9738091107193247 0.9419272700722532 0.883642767167473 1.049579761789042 0.9566271460327105 1.0282227138923539 1.0336815253407308 1.0 13.669132670549175 -5.108193924015948 2.904202078373851 0.9801501036064394 1.2705656415984554 0.8152658113738832 0.04749291318257149 0.11372489438964584 1.7593229704994313 0.013326269948237443 0.05276641942357569 7.794819734077664e-06 5.108193924015948 0.290415537992016 LTPVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R2 5 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LTPVS(1)PESSSTEEK;LTPVS(1)PESSSTEEK;LTPVS(0.927)PES(0.063)S(0.007)S(0.001)TEEK;LTPVS(0.868)PES(0.105)S(0.027)STEEK;LTPVS(0.903)PES(0.048)S(0.043)S(0.004)T(0.001)EEK 269.05 2.9258999999999997e-44 2324594000.0 1119196.0 887970.0 1019715.0 1068290.0 1039980.0 801813.0 1004394.0 893479.0 824306.0 962769.0 True False 1056995.5668165688 956074.4437264308 954107.6470817444 922787.0590969623 909328.4148608379 912255.4626162797 1051100.3111689547 896078.8759665898 989190.2330340052 934971.3573957267 1.130511173904545 1.022570837238784 1.0204672469746239 0.986968265709548 0.9725735528344795 0.9757041810962852 1.1242058944957352 0.9584024888875011 1.057989878737355 1.0 19.83456264352683 -4.749843984367063 3.772908237066966 1.0113948207975478 1.1472637858316466 0.36934888558174406 0.04615178191295845 0.3222333832649506 7.78090237919306 0.011388185936065793 0.128103366310184 1.7789183525969997e-05 4.749843984367063 0.13586896503409873 LTPVS(ph)PVQHQGATVNNTNK ddPTM_A459_Selumetinib_30min_R2 2 LTPVSPVQHQGATVNNTNK 19 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 LT(0.099)PVS(0.901)PVQHQGATVNNTNK;LT(0.205)PVS(0.795)PVQHQGATVNNTNK 100.85 0.0017978999999999996 13516000.0 100248.0 116229.0 116133.0 141715.0 138684.0 89500.0 86776.0 113056.0 79805.0 129844.0 True False 94676.61748453994 125143.39056486073 108661.1292160501 122413.17252798917 121261.27606930934 101827.81259989174 90811.25594338197 113384.97424257164 95768.22993800722 126095.06634477299 0.7508352247951734 0.9924527120092854 0.8617397362633168 0.9708006512584983 0.9616655082900155 0.8075479521258272 0.7201808807894439 0.8992023044942217 0.7594922839895638 1.0 16.94415230363844 -6.774591166731967 24.99655543783391 0.8236658247713337 0.9131930357401026 0.10795098553361127 0.0963558457393238 409.23289804614285 777791.552962558 0.03207066037084642 0.028450122860142417 1.6803851436476987e-07 6.774591166731967 0.08952721096876892 LTPVSLS(ph)NSPIKGADCQEVPQDK ddPTM_A459_Selumetinib_30min_R1 2 LTPVSLSNSPIKGADCQEVPQDK 23 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LTPVS(0.061)LS(0.609)NS(0.329)PIKGADCQEVPQDK;LT(0.002)PVS(0.07)LS(0.501)NS(0.427)PIKGADCQEVPQDK 71.946 0.0010141 108094000.0 5623.6 7719.2 5492.4 5787.2 5335.7 6058.1 6077.299999999999 6094.4 3336.5 6484.6 True False 5754.618938379236 6815.43247544128 4746.5622475936425 4776.574159198375 4853.086877094346 5997.161014314703 5618.884368137698 5932.756714598864 5661.796811681615 7316.961575352927 0.7864765830892951 0.9314566442987702 0.6487067341698725 0.6528084246455785 0.6632653222400259 0.8196245056849892 0.7679259088997848 0.8108224504804377 0.7737906989635275 1.0 12.837028967298489 -9.460621477072557 0.622367712549393 1.012362808434395 0.7490788212042193 0.43424901411105443 0.08267888571840393 4.161053392380796 1.938891496094415 0.22021601620573952 0.0361815375724611 3.4624102353677897e-10 9.460621477072557 -0.26328398723017565 LTPVSLS(ph)NSPIKGADCQEVPQDK ddPTM_A459_Selumetinib_30min_R2 2 LTPVSLSNSPIKGADCQEVPQDK 23 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LTPVS(0.107)LS(0.488)NS(0.405)PIKGADCQEVPQDK;LTPVS(0.07)LS(0.77)NS(0.159)PIKGADCQEVPQDK 65.915 0.0022952 108215000.0 172777.0 143450.0 180080.0 185035.0 170238.0 156809.0 187472.0 175056.0 150988.0 149612.0 True False 163174.74602113137 154452.15373555015 168493.84885627916 159832.9137968209 148851.18049297025 178408.01637962498 196189.81946872067 175565.38397791897 181189.81895720583 145292.3128213404 1.1230790043364525 1.0630442226181176 1.1596886688937815 1.1000782539222185 1.0244945352064567 1.2279246776049708 1.3503110774344043 1.2083597581229506 1.247070925080579 1.0 17.148598848791536 -6.783563359499307 24.202356612493237 1.228729482586818 1.0963314169962444 0.2707788175796675 0.08880508931958148 183.3494345807764 200571.8167716906 0.029883269892053952 0.026378290380953105 1.6460258090539338e-07 6.783563359499307 -0.13239806559057365 LTPVSLSNS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 2 LTPVSLSNSPIK 12 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LTPVSLS(0.011)NS(0.989)PIK;LTPVSLS(0.033)NS(0.967)PIK 192.54 0.00010438 185224000.0 11549.2 17891.8 9140.3 9623.7 9900.9 10532.8 12862.4 11845.1 6559.9 11492.4 True False 11818.27388916877 15797.01973832784 7899.097464074018 7943.101454222656 9005.365343145866 10426.84959501723 11892.178812422355 11530.929469692668 11131.6711838604 12967.561485455688 0.9113721112812189 1.2181950905762544 0.6091428579639727 0.6125362477079114 0.694453259639155 0.8040717298091781 0.9170713264603007 0.889213402429259 0.8584243997104307 1.0 13.662619589779176 -8.449562954195365 0.862957837703515 0.9897586822308388 0.8140128622565002 0.08952145891535346 0.16762970355961637 1.7654807130128234 2.933745692752612 0.1776845545834021 0.06379055295663577 3.551706301424167e-09 8.449562954195365 -0.1757458199743387 LTPVSLSNS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 1 LTPVSLSNSPIK 12 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LTPVSLS(0.05)NS(0.95)PIK 96.707 0.016873 95847000.0 102730.0 70443.0 82849.0 93088.0 98368.0 88109.0 99268.0 119080.0 96013.0 82221.0 True False 97020.67786077315 75845.75159005476 77518.58553917077 80409.25381424319 86010.13241892225 100245.21497613245 103884.15869581037 119426.50308524474 115218.28282736544 79847.06609418675 1.215081312396984 0.9498877704609449 0.9708382452992158 1.0070408062256575 1.0771858832917618 1.2554652272117834 1.3010391461756368 1.4956905610579416 1.442987055923322 1.0 16.284951777679005 -6.845125806785878 2.100899726016374 1.3507443233361558 1.0242482183842565 0.4438011968915675 0.14135886971640116 0.25264638431365466 2.2859608869836707 0.05628245655883647 0.04894197163076864 1.4284800952705811e-07 6.845125806785878 -0.3264961049518993 LTPVSLSNS(ph)PIKGADCQEVPQDKDGYK ddPTM_A459_Selumetinib_30min_R1 1 LTPVSLSNSPIKGADCQEVPQDKDGYK 27 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LT(0.001)PVS(0.046)LS(0.106)NS(0.847)PIKGADCQEVPQDKDGYK 59.56100000000001 0.0021968000000000005 159410000.0 4042.2 4087.1 5303.8 6268.8 4514.0 4516.6 4007.7 4339.1 2432.1 3519.9 True False 4136.375395247985 3608.5804319587583 4583.573091687994 5174.0717599500185 4105.7094970114285 4471.167104744684 3705.3959623822175 4224.012972616816 4127.096066444135 3971.713451729443 1.0414586665225916 0.9085701865998006 1.1540543262737453 1.30273037640644 1.033737591321861 1.1257526906423119 0.932946449288465 1.0635240995992579 1.039122312473734 1.0 11.955545824778763 -7.2356917416431585 24.815250798557834 1.0141918606326519 1.095363818349327 0.14986658976867862 0.09940915338677314 1581.5812299245258 1524309.6561103808 0.04116929145085995 0.03187653621946134 5.811767852646344e-08 7.2356917416431585 0.08117195771667518 LTPVSLSNS(ph)PIKGADCQEVPQDKDGYK ddPTM_A459_Selumetinib_30min_R2 1 LTPVSLSNSPIKGADCQEVPQDKDGYK 27 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2 P46100-4 ATRX Transcriptional regulator ATRX 1 LT(0.001)PVS(0.017)LS(0.111)NS(0.871)PIKGADCQEVPQDKDGY(0.001)K 48.198 0.016058000000000003 33097000.0 92876.0 99711.0 103040.0 102830.0 98370.0 65142.0 64649.0 70180.0 53188.0 95471.0 True False 87714.32373208576 107358.51307860202 96410.5185814693 88824.37660835587 86011.88116104211 74114.71919980066 67655.30659956328 70384.21218107548 63827.086196889046 92714.50416655235 0.9460690592112291 1.1579473356805443 1.0398644683282503 0.9580418663383212 0.9277068559470518 0.7993864591742945 0.7297165336507357 0.7591499605567352 0.6884261181209583 1.0 16.500507429860036 -6.42123261240484 1.397612570745083 0.7712761423316412 1.0553934128332725 0.573721929981856 0.09372593242679782 0.26200510785878384 1.0420736162019895 0.03618277651202746 0.04393290228558798 3.7911187452810025e-07 6.42123261240484 0.28411727050163127 LTPVSPES(ph)SSTEEK ddPTM_A459_Selumetinib_30min_R2 2 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LTPVS(0.292)PES(0.537)S(0.158)S(0.011)T(0.002)EEK;LT(0.001)PVS(0.221)PES(0.552)S(0.164)S(0.049)T(0.014)EEK 148.85 0.00045142 659670100.0 209639.0 198977.0 223432.0 214577.0 197464.0 162507.0 211603.0 191563.0 165854.0 194799.0 True False 197988.103631409 214237.89608810467 209056.62837436784 185351.2424340288 172656.80696944214 184890.8641583307 221442.95878338977 192120.41661503818 199029.43434795103 189174.64672141484 1.0465889962674182 1.132487359173446 1.105098553096451 0.97978902377433 0.9126847067604283 0.9773554086801463 1.1705741896243336 1.015571694963762 1.0520935960358826 1.0 17.529359225375153 -5.747878636418047 24.900822391766486 1.0166829945329976 1.0985012428279386 0.23486217743349247 0.06544685148544331 354.2418144039168 650467.7394147378 0.019382321900996417 0.03333260861094593 1.7869868785214818e-06 5.747878636418047 0.081818248294941 LTPVSPESS(ph)STEEK ddPTM_A459_Selumetinib_30min_R1 1 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LTPVSPES(0.022)S(0.452)S(0.452)T(0.075)EEK 225.6 6.0588e-10 11793000.0 6857.5 7622.6 7250.2 7272.5 6024.3 7300.0 7567.2 7276.4 3873.0 6140.9 True False 7017.26640762779 6730.142448349403 6265.662662497889 6002.4943967324725 5479.40312867655 7226.568627869675 6996.400011612326 7083.4062349217575 6572.19812727196 6929.144332431414 1.0127175984463084 0.9712804533237105 0.9042476764658889 0.8662677682492749 0.7907763016323035 1.0429236686622596 1.0097062026643213 1.0222627636385535 0.9484862505333033 1.0 12.758461492208445 -6.805743433037942 24.999887921758322 1.0063816367212146 0.909869582936788 0.3917813725687105 0.05954513179926292 155.17208641373355 87559.40722785327 0.022842260302234584 0.020145081722272716 1.5640713719218383e-07 6.805743433037942 -0.09651205378442662 LTPVSPESS(ph)STEEK ddPTM_A459_Selumetinib_30min_R2 2 LTPVSPESSSTEEK 14 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 LTPVSPES(0.032)S(0.84)S(0.123)T(0.005)EEK;LTPVS(0.274)PES(0.274)S(0.341)S(0.088)T(0.023)EEK 239.51 1.7425e-19 31130100.0 87099.0 67421.0 82596.0 74830.0 75934.0 60700.0 84802.0 76909.0 54625.0 74831.0 True False 82258.38626492255 72591.97390731628 77281.86328372532 64638.02491104992 66394.49206142702 69060.87402026178 88745.46103197511 77132.79245702959 65551.52635002385 72670.43459571242 1.1319374477743362 0.9989203217397469 1.0634567374430561 0.8894679833779828 0.9136382963828363 0.9503297235590826 1.2212044901849415 1.061405410414051 0.9020384522909047 1.0 16.14908091374015 -10.251625436509325 15.2259166753338 1.0000295435183773 1.0145770456647811 0.001869019902973168 0.10194566232644321 0.0 0.0 0.10352612466331435 0.025108773352806275 5.602405806948777e-11 10.251625436509325 0.014547502146403879 LTPYEVDELRR ddPTM_A459_Selumetinib_30min_R2 1 LTPYEVDELRR 11 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 109.16 0.012932 2380300.0 15010.0 16382.0 19247.0 18878.0 13629.0 14187.0 11781.0 13052.0 10990.0 13965.0 False True 14175.804289790778 17638.446723567686 18008.66897454913 16306.78383363358 11916.803175194093 16141.130473236468 12328.839843608632 13089.979159125085 13188.307086256491 13561.794164572502 1.045274992214692 1.300598321249015 1.3278972351308211 1.2024060854891767 0.8787040291707404 1.1901913771410844 0.9090861942010063 0.9652099862509387 0.972460348993375 1.0 13.727260432736445 -6.1487482801388795 6.201742195568562 0.9911365491351823 1.2367659831181748 0.5425271156601297 0.10463260057823799 0.17935869249732783 8.655912440488178 0.030565390209909244 0.039708256949578476 7.099891629909533e-07 6.1487482801388795 0.24562943398299242 LTQAEISEQPTMATVVPQVPT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 LTQAEISEQPTMATVVPQVPTSPK 24 0 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 LTQAEISEQPTMATVVPQVPT(0.815)S(0.185)PK 103.85 1.9659e-06 9329800.0 1507.5 1761.3 1992.4 2150.7 1406.3 1411.3 1369.7 1549.1 1039.9 1305.2 True False 1542.6218169156245 1555.0861771938448 1721.8430234698083 1775.1206186390548 1279.1004133024303 1397.1036033578744 1266.382426248203 1508.012835814042 1764.634348709039 1472.7351337246141 1.0474536673911377 1.0559170767257797 1.1691464296877259 1.2053223814588399 0.8685203360821081 0.9486455312738659 0.8598847119545959 1.0239538673870088 1.1982021127221962 1.0 10.52428227469537 -6.25622343793069 24.973658266095757 0.976505189894906 1.1184701514051671 0.31332389997081955 0.09851790373118754 567.1541787651832 2715502.726708825 0.03151390182253598 0.039455889383706845 5.543404398226969e-07 6.25622343793069 0.14196496151026117 LTQTS(ph)STEQLNVLETETEVLNK ddPTM_A459_Selumetinib_30min_R2 1 LTQTSSTEQLNVLETETEVLNK 22 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 LT(0.012)QT(0.15)S(0.465)S(0.282)T(0.091)EQLNVLETETEVLNK 138.37 8.0198e-06 5275900.0 16156.0 13296.0 16677.0 17894.0 17770.0 13715.0 15705.0 13628.0 11775.0 14687.0 True False 15258.11419759225 14315.760446621667 15604.019976544694 15456.806331128255 15537.573734184381 15604.116757625872 16435.31361886712 13667.65522376315 14130.329020989093 14262.948148591222 1.069772815453958 1.0037027616927614 1.0940248687706218 1.0837034650970776 1.0893662076251085 1.0940316542598607 1.1523083059437798 0.9582629819146562 0.9907018432500416 1.0 13.799984596937566 -7.779399719814385 24.999998095186797 0.9808617706385344 1.081752284532643 0.6294238642842303 0.03542652898898066 172.0413052330073 239470.47408497107 0.020412502595432355 0.009838186566325487 1.661882368189359e-08 7.779399719814385 0.10089051389410864 LTQTSS(ph)TEQLNVLETETEVLNK ddPTM_A459_Selumetinib_30min_R1 3 LTQTSSTEQLNVLETETEVLNK 22 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 LT(0.024)QT(0.078)S(0.33)S(0.447)T(0.12)EQLNVLETETEVLNK;LT(0.003)QT(0.052)S(0.176)S(0.593)T(0.176)EQLNVLETETEVLNK;LT(0.004)QT(0.059)S(0.183)S(0.57)T(0.183)EQLNVLETETEVLNK 208.16 1.5236e-23 26078400.0 8130.700000000001 10346.1 9113.4 9781.4 9816.4 8383.1 9666.7 9897.8 5175.9 7948.799999999999 True False 8320.129490411851 9134.773802228607 7875.850336322896 8073.262109618286 8928.508353226183 8298.773625245798 8937.533036295177 9635.278191414514 8783.124267220997 8969.10590786869 0.9276431314198793 1.0184709486164696 0.8781087454228107 0.9001189407893521 0.9954736230055116 0.9252620841465589 0.996479819516256 1.0742741016093236 0.9792641939388262 1.0 13.130748460823988 -7.423430106165277 4.699001369886937 1.022762994630501 0.9425013646612338 0.38245911284014256 0.04492282825890159 0.23153639073242688 8.31812758260692 0.01966014076725429 0.012812426686421961 3.771984451251246e-08 7.423430106165277 -0.08026162996926722 LTQTSS(ph)TEQLNVLETETEVLNK ddPTM_A459_Selumetinib_30min_R2 3 LTQTSSTEQLNVLETETEVLNK 22 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 LT(0.021)QT(0.161)S(0.161)S(0.495)T(0.161)EQLNVLETETEVLNK;LT(0.012)QT(0.059)S(0.182)S(0.564)T(0.182)EQLNVLETETEVLNK;LT(0.006)QT(0.062)S(0.186)S(0.56)T(0.186)EQLNVLETETEVLNK 134.53 1.2373e-05 22173000.0 84480.0 84923.0 96081.0 105268.0 100606.0 79010.0 83992.0 83374.0 71669.0 85020.0 True False 79784.93980023485 91436.32102951666 89899.253065083 90930.316802571 87966.97485094858 89892.91031863069 87897.79442699059 83616.60453669132 86004.80259917329 82565.25169151124 0.9663258836578797 1.1074431332341894 1.0888267306563033 1.101314595906692 1.0654236867056353 1.0887499096411382 1.0645857988225282 1.0127335994700077 1.0416585771519629 1.0 16.33324711809567 -7.6898091742276335 5.084557124614671 1.0204034607802062 1.073659563646939 0.26249944269353676 0.03861159417954141 0.2645904087729055 12.52714007937347 0.018652698093295846 0.010292283177614424 2.0426352662940865e-08 7.6898091742276335 0.05325610286673288 LTQYHGGS(ph)LPNVSQLR ddPTM_A459_Selumetinib_30min_R1 2 LTQYHGGSLPNVSQLR 16 0 Q6UUV7;Q6UUV7-3;H0YK33 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 LTQYHGGS(1)LPNVSQLR;LT(0.001)QY(0.001)HGGS(0.997)LPNVS(0.001)QLR 114.75 0.0013591 26730000.0 4043.7 4730.5 5244.9 5611.3 6013.4 4524.5 5288.0 4753.4 2565.33 4238.1 True False 4137.910342329493 4176.6508608502145 4532.671388173457 4631.391792146429 5469.489031752002 4478.98763791731 4889.121902606778 4627.324390780756 4353.177645709933 4782.101417589866 0.8652912142576349 0.8733923637602832 0.9478409160251311 0.9684846446607999 1.1437417474321514 0.9366149411725938 1.0223793842228568 0.9676340977964629 0.9103064250577716 1.0 12.223429011345347 -5.435992041027557 2.2117027430725487 0.9964458904589208 0.8647572012252085 0.4086782810111491 0.05901092723860263 0.32039129110095715 3.0092654319913734 0.017186202515233017 0.04723540156610539 3.664442901217899e-06 5.435992041027557 -0.13168868923371235 LTQYHGGS(ph)LPNVSQLR ddPTM_A459_Selumetinib_30min_R2 4 LTQYHGGSLPNVSQLR 16 0 Q6UUV7;Q6UUV7-3;H0YK33 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 LT(0.002)QY(0.012)HGGS(0.968)LPNVS(0.018)QLR;LT(0.01)QY(0.005)HGGS(0.984)LPNVS(0.001)QLR;LT(0.017)QY(0.006)HGGS(0.977)LPNVSQLR;LTQYHGGS(0.995)LPNVS(0.005)QLR 98.077 0.0072798 27592600.0 137668.3 125647.3 137461.0 168100.0 184725.0 131653.9 123757.5 135961.6 106208.2 115097.7 True False 130017.2470158697 135284.0438902534 128616.90891622072 145204.49001132563 161518.19403754693 149788.02968988713 129512.46897083412 136357.22574634536 127452.8077050546 111774.53034126156 1.1632099604347328 1.210329790491755 1.150681720813653 1.299083875083154 1.4450357657009318 1.3400908886180565 1.1586939222684849 1.2199310999565802 1.1402669938842533 1.0 16.77023195835578 -8.52049335775235 1.1222638662456073 1.0023938698178085 1.2612950113418424 0.4575377374877563 0.0863421909617039 0.5444231706351119 1.5043038577547565 0.09273360012655192 0.02964356094659188 3.016523008539195e-09 8.52049335775235 0.2589011415240339 LTRPAAS(ph)PAVGEK ddPTM_A459_Selumetinib_30min_R1 3 LTRPAASPAVGEK 13 1 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 LTRPAAS(1)PAVGEK;LT(0.008)RPAAS(0.992)PAVGEK;LT(0.001)RPAAS(0.999)PAVGEK 122.75 0.012283 130546000.0 7835.4 9301.2 10173.400000000001 10626.400000000001 8370.3 8093.6 8339.8 7443.099999999999 4828.7 7157.5 True False 8017.949574965626 8212.211179989432 8791.90815848612 8770.698722232786 7613.207842896494 8012.185732400826 7710.722171588502 7245.6848094038505 8193.951225705689 8076.234844953974 0.9927831135291014 1.0168365999312683 1.0886147229831111 1.0859885690065976 0.9426679621201483 0.9920694341134513 0.9547421935614162 0.8971612327408915 1.0145756510318993 1.0 12.979467147377584 -6.269523595795138 24.897066660783583 0.9623811120810429 1.0470085962770106 0.4701067115721568 0.041015490284043186 503.58571987718256 1550897.1320288803 0.013061061854570144 0.01506586317447256 5.376212226547506e-07 6.269523595795138 0.08462748419596766 LTRPAAS(ph)PAVGEK ddPTM_A459_Selumetinib_30min_R2 1 LTRPAASPAVGEK 13 1 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 LTRPAAS(1)PAVGEK 90.872 0.011298 91295000.0 116020.0 115430.0 122380.0 121510.0 115580.0 88026.0 98328.0 85989.0 67538.0 99857.0 True False 109572.07286485846 124283.10983405086 114506.20403726917 104960.12838355817 101059.80710169004 100150.78247953152 102900.4468332356 86239.2137537548 81047.48716938964 96973.86895035584 1.1299133885330703 1.2816144305604176 1.1807944271656183 1.0823547572108396 1.0421344244130955 1.0327605112961107 1.061115205024085 0.8893036308358856 0.8357662538026667 1.0 16.565308423606176 -6.509567246310319 0.644021539543499 0.9120125791839309 1.226670695487295 0.7099680779844346 0.0665621185959637 0.4473274159016584 0.4097157195904159 0.05015045560786172 0.07083779136295167 3.093376298893002e-07 6.509567246310319 0.31465811630336415 LTS(ph)DEEGEPSGK ddPTM_A459_Selumetinib_30min_R1 3 LTSDEEGEPSGK 12 0 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 LT(0.129)S(0.871)DEEGEPSGK;LT(0.02)S(0.98)DEEGEPSGK;LT(0.057)S(0.943)DEEGEPSGK 243.85 9.947300000000001e-14 97163000.0 21782.600000000002 26197.399999999998 19899.0 18426.4 18996.3 18845.6 23131.5 20178.3 10666.7 18825.8 True False 22290.092198438655 23130.196229159163 17196.825097382905 15208.575146366611 17278.088019069157 18656.03037443572 21386.672331722497 19643.10593564425 18100.610835055988 21242.274808820755 1.0493269858830185 1.088875670676968 0.8095566624645117 0.7159579321538257 0.8133821906820691 0.8782501188003128 1.0067976487547265 0.9247176261690928 0.8521032233110831 1.0 14.374650650384242 -5.25431787419959 24.75958182804286 0.8693357749419197 1.069101355727858 0.45985575175448534 0.08391879967265987 452.531202834587 1573318.9048452047 0.023701600302096764 0.0599158528338342 5.567780758459011e-06 5.25431787419959 0.1997655807859382 LTS(ph)DEEGEPSGK ddPTM_A459_Selumetinib_30min_R2 4 LTSDEEGEPSGK 12 0 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 LT(0.226)S(0.774)DEEGEPSGK;LT(0.028)S(0.972)DEEGEPSGK;LT(0.301)S(0.699)DEEGEPSGK;LT(0.043)S(0.957)DEEGEPSGK 218.02 4.474e-08 183748000.0 715223.0 601342.0 680072.0 733926.0 729947.0 626230.0 763705.0 810095.0 614695.0 603148.0 True False 675473.7689245187 647462.9977807121 636316.9079264092 633964.0127070316 638244.5320510231 712487.4981500587 799218.795752749 812452.2423315523 737651.1760133241 585733.5500732944 1.1532099686623634 1.1053882737290588 1.0863589901018733 1.0823419840432598 1.089649947439681 1.2164020620995728 1.364475017100763 1.3870679632913088 1.2593630259373392 1.0 19.159885006989278 -6.91346706410262 3.9826255459295026 1.2859394434521352 1.1018007981415834 0.31253756045677994 0.1013357653040228 0.2140348822539731 6.490047799281378 0.03575361592859317 0.031063936697207955 1.2204863761220544e-07 6.91346706410262 -0.1841386453105518 LTS(ph)DEEGEPSGKR ddPTM_A459_Selumetinib_30min_R1 1 LTSDEEGEPSGKR 13 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 LT(0.01)S(0.99)DEEGEPSGKR 161.25 0.00065314 18921000.0 3403.0 3756.7 4362.3 4696.9 3749.5 3045.3 3325.6 3646.6 2232.3 2901.0 True False 3482.283278914674 3316.863817557553 3769.9236203986843 3876.6745867325894 3410.3583870279913 3014.667046911169 3074.74731454408 3549.880322173835 3788.0500592587673 3273.371608132936 1.0638215564229498 1.0132866703299306 1.1516943603445535 1.184306290523417 1.0418488321199773 0.9209669441199415 0.939321190085672 1.0844721428370345 1.1572319042075987 1.0 11.676561677688866 -6.507896524637652 24.722391334906572 1.016254760854798 1.101903930851568 0.20860200436969156 0.07639597344473177 1050.5864118808647 1733590.7467518 0.0266876001610512 0.029265051411461015 3.105299371189942e-07 6.507896524637652 0.08564916999676986 LTS(ph)SCPDLPSQTDKK ddPTM_A459_Selumetinib_30min_R2 1 LTSSCPDLPSQTDKK 15 1 P56962 P56962 STX17 Syntaxin-17 1 LT(0.028)S(0.486)S(0.486)CPDLPSQTDKK 73.953 0.021388 6807000.0 19604.0 16126.0 16076.0 23310.0 17525.0 13530.0 15217.0 13012.0 10585.0 17084.0 True False 18514.48816102987 17362.812346737435 15041.687662225373 20135.137788007134 15323.352824512187 15393.634686888667 15924.620651913474 13049.862765747435 12702.29576961101 16590.740530437284 1.1159530900422008 1.0465363083030388 0.9066314812548586 1.2136370737079105 0.9236087320153097 0.9278449421017456 0.9598499007743656 0.7865750622647751 0.7656256058195501 1.0 14.018090662211275 -6.876903552487574 1.2300174371028625 0.8501603273323723 1.055993407909322 0.39908017897074166 0.10124819278227686 0.45231599922763194 1.427778543022961 0.05335426620994748 0.043176736381162824 1.3276892763736023e-07 6.876903552487574 0.2058330805769497 LTSPVTSIS(ph)PIQASEK ddPTM_A459_Selumetinib_30min_R1 2 LTSPVTSISPIQASEK 16 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4 Q7Z589 EMSY;C11orf30 Protein EMSY 1 LTSPVTS(0.001)IS(0.999)PIQASEK;LTSPVT(0.001)S(0.004)IS(0.994)PIQASEK 176.42 1.2111e-06 20782200.0 3993.9 4489.6 4595.2 4679.9 4398.8 3704.1 4572.9 4080.7 2168.66 3072.0 True False 4086.9500992234216 3963.9555448415863 3971.1970796268124 3862.643317603065 4000.9293166712155 3666.840117053707 4227.962471337086 3972.466580018309 3680.057627340461 3466.3211238139875 1.1790454355615376 1.1435627004113378 1.1456518129103141 1.114335106192644 1.1542292747156095 1.0578477833060917 1.2197261362458727 1.1460180514514506 1.0616609067342553 1.0 11.759189598212025 -8.458876556207603 3.0423916306998837 1.0013400613241907 1.1438106673451471 0.5939218623722091 0.0393561996169563 0.15715687285415478 3.0539762299680944 0.037072455569631395 0.009916587101233769 3.476349591052573e-09 8.458876556207603 0.1424706060209564 LTSPVTSIS(ph)PIQASEK ddPTM_A459_Selumetinib_30min_R2 2 LTSPVTSISPIQASEK 16 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4 Q7Z589 EMSY;C11orf30 Protein EMSY 1 LTSPVTSIS(0.998)PIQAS(0.002)EK;LT(0.023)S(0.003)PVTSIS(0.973)PIQASEK 199.91 7.727600000000002e-07 14135200.0 52695.0 49682.0 57505.0 58936.0 53434.0 41278.0 41599.0 49366.0 36932.0 45478.0 True False 49766.42285479846 53492.44964719147 53805.19090671 50908.81512972925 46721.14321397912 46963.6698156238 43533.435926854734 49509.64688701877 44319.4319662989 44164.93197396551 1.12683119005221 1.2111973743947884 1.218278586694694 1.1526976914566323 1.0578787541554564 1.0633701381745158 0.9857014146997207 1.121017166203355 1.0034982504314613 1.0 15.430613668900047 -6.2232077363130625 2.6879611879761858 1.040462613059691 1.188417893098866 0.7197849631680833 0.042819320646844794 0.14746980119947434 2.1118294500282757 0.013353156571797154 0.017280658464632996 5.981254249676734e-07 6.2232077363130625 0.14795528003917502 LTSS(ph)CPDLPSQTDKK ddPTM_A459_Selumetinib_30min_R1 1 LTSSCPDLPSQTDKK 15 1 P56962 P56962 STX17 Syntaxin-17 1 LT(0.041)S(0.176)S(0.783)CPDLPSQTDKK 89.344 0.008569799999999999 9708600.0 1655.8 1937.0 2121.7 2212.6 1817.2 1802.5 1815.1 1588.1 1050.5 1574.1 True False 1694.3769183740562 1710.2151395131295 1833.584793663867 1826.210945645963 1652.8345808527185 1784.3684865390533 1678.1855456546057 1545.9784291241895 1782.6217745156712 1776.1510680324202 0.9539599130219528 0.9628770718290686 1.0323360589451833 1.0281844706312049 0.9305709466952555 1.004626531298228 0.9448439245168833 0.8704093119943842 1.0036431059270308 1.0 10.79453857796747 -7.281699202912969 21.598694121384153 0.9439248150634214 0.985983336130396 0.07862006596210536 0.04585093976017936 277.9624444845585 296326.62412203645 0.019102955365101492 0.012911697310067518 5.227581316160209e-08 7.281699202912969 0.04205852106697461 LTSS(ph)CPDLPSQTDKK ddPTM_A459_Selumetinib_30min_R2 3 LTSSCPDLPSQTDKK 15 1 P56962 P56962 STX17 Syntaxin-17 1 LT(0.067)S(0.215)S(0.717)CPDLPSQTDKK;LT(0.003)S(0.058)S(0.939)CPDLPSQTDKK;LT(0.012)S(0.306)S(0.681)CPDLPSQTDKK 114.58 0.0012739 17388600.0 88930.0 84324.0 92045.0 100626.0 88451.0 77882.0 78737.0 83062.0 61980.0 83265.0 True False 83987.62661499622 90791.37965560527 86122.92491101859 86920.56521046764 77338.9946180272 88609.53855759514 82398.42651440568 83303.69666834576 74377.73186589428 80860.92310154872 1.038667670285199 1.1228090921196316 1.0650747185121994 1.074939066689963 0.9564446168998277 1.0958264531103035 1.0190141709231553 1.0302095681461525 0.9198229381142167 1.0 16.303155052939232 -7.015402582085493 0.5066125261852124 0.9744362094928676 1.0849327169933614 0.342884937064468 0.04781295388646551 1.1381243815227897 0.626547066907727 0.04432845907367973 0.04715467975882533 9.651557845517653e-08 7.015402582085493 0.11049650750049378 LTSS(ph)LEAGLQR ddPTM_A459_Selumetinib_30min_R2 1 LTSSLEAGLQR 11 0 B7Z879;A0A087WXL6;Q9H270 B7Z879 VPS11 Vacuolar protein sorting-associated protein 11 homolog 1 LTS(0.045)S(0.955)LEAGLQR 155.47 0.00053471 7304200.0 32703.0 26566.0 29282.0 33145.0 36513.0 22656.0 19492.0 26987.0 21084.0 22675.0 True False 30885.49818048154 28603.52677684649 27398.027999831014 28630.59382168583 31925.910509638423 25776.6583493089 20398.41662266527 27065.527702061627 25301.389136181235 22020.313833274733 1.4025911898590062 1.2989609046181674 1.244216054651776 1.3001900898624956 1.4498390327841475 1.1705854214647013 0.9263454089306109 1.2291163471595536 1.1490022044076635 1.0 14.42654740987238 -6.961817036114028 7.856665590313935 1.0885583680262674 1.3282642963281281 0.6414152824588688 0.09306410015097681 0.1563028738506028 27.395402180916832 0.03337469835405868 0.029282881631956213 1.091900246127702e-07 6.961817036114028 0.23970592830186077 LTTAS(ph)QTNIK ddPTM_A459_Selumetinib_30min_R2 1 LTTASQTNIK 10 0 H7C2B1;Q9UMY1-2;Q9UMY1 H7C2B1 NOL7 Nucleolar protein 7 1 LT(0.118)T(0.011)AS(0.776)QT(0.095)NIK 102.73 0.014976 2898400.0 11904.0 12190.0 14009.0 12155.0 13565.0 14094.0 12124.0 12945.0 10599.0 12971.0 True False 11242.423335487632 13124.933802972178 13107.676191845934 10499.46803145546 11860.843427361347 16035.320567406417 12687.79002325023 12982.667806839883 12719.096160803687 12596.493527294659 0.8925041965946344 1.041951379130428 1.0405813461852398 0.8335230759817986 0.9415988188824714 1.2729987541898347 1.0072477706401188 1.0306572840059374 1.0097330763710843 1.0 13.620734567654003 LTTEATQT(ph)PVSNK ddPTM_A459_Selumetinib_30min_R2 1 LTTEATQTPVSNK 13 0 Q9BXS6-4;Q9BXS6-6;Q9BXS6-3;Q9BXS6-5;Q9BXS6-2;Q9BXS6 Q9BXS6-4 NUSAP1 Nucleolar and spindle-associated protein 1 1 LTT(0.002)EAT(0.411)QT(0.58)PVS(0.007)NK 130.66 0.00314 0.0 6919.8 9767.4 7054.7 8092.3 7203.9 7301.4 7755.8 6237.9 7778.2 9018.7 True False 6535.225218154177 10516.52817285893 6600.808282576593 6990.1147800038625 6298.8816783168795 8307.101574489943 8116.460067826145 6256.051256260064 9334.057341066442 8758.306697603299 0.7461745111007057 1.2007490187271892 0.7536626097351554 0.7981125828713785 0.7191894387576724 0.9484826075756371 0.9267156709695044 0.714299175886593 1.0657376663483018 1.0 13.09643625550358 -9.967518209416573 8.8035521121137 0.9999999387154456 0.8729582625732393 0.05586796070923805 0.15424962533010453 0.0 0.0 0.14395881586217563 0.03491514138462314 1.0776600678277769e-10 9.967518209416573 -0.1270416761422063 LTTTGQVT(ph)SPVK ddPTM_A459_Selumetinib_30min_R1 3 LTTTGQVTSPVK 12 0 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTTGQVT(0.5)S(0.5)PVK;LTTTGQVT(0.5)S(0.5)PVK;LTTTGQVT(0.5)S(0.5)PVK 190.35 0.00024191 231910000.0 25943.199999999997 34096.1 22723.7 24751.100000000002 22356.9 23486.2 27323.9 24956.5 13535.5 24113.3 True False 26547.626083320334 30104.11276115313 19637.94635234937 20428.78502068961 20334.722342431272 23249.95015176342 25262.836224401904 24294.57254986325 22968.754906194063 27208.47693843224 0.9757115822172888 1.1064240320865142 0.7217583842265929 0.750824276820646 0.7473671675355072 0.8545112688363177 0.9284913772118535 0.8929045387155401 0.8441764292124148 1.0 14.731768579986007 -5.253079619771192 24.927600761235666 0.8355071046821467 1.0410678167206346 0.4524934313949064 0.08709550158321762 533.6501215714171 1591258.7764326504 0.0232116535038385 0.05926740232258588 5.583678190556131e-06 5.253079619771192 0.2055607120384879 LTTTGQVT(ph)SPVK ddPTM_A459_Selumetinib_30min_R2 3 LTTTGQVTSPVK 12 0 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTTGQVT(0.5)S(0.5)PVK;LTTTGQVT(0.775)S(0.225)PVK;LTTTGQVT(0.5)S(0.5)PVK 245.5 7.61e-14 742376000.0 3330760.0 2744480.0 3134610.0 3133880.0 3081260.0 2692700.0 3336600.0 3393650.0 2633170.0 2765000.0 True False 3145649.6932887086 2954972.7911059125 2932932.605305318 2707040.1377554554 2694164.5719861025 3063594.983103114 3491758.511347473 3403524.9596509975 3159877.5769170164 2685167.265667234 1.1714911519700244 1.1004799696795182 1.0922718457080984 1.00814581362133 1.0033507433350275 1.140932642176332 1.300387709917881 1.2675280989637938 1.1767898474405922 1.0 21.356580529353288 -7.000500936951288 24.95538567901742 1.2102118199017506 1.0736199654091618 0.24840242863472894 0.0875189317837275 20.241600252220152 1008433.5823067807 0.030827751784534813 0.02688595506198063 9.988472150111424e-08 7.000500936951288 -0.13659185449258882 LTTTGQVT(ph)SPVKGASFVTSTNPR ddPTM_A459_Selumetinib_30min_R1 1 LTTTGQVTSPVKGASFVTSTNPR 23 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTTGQVT(0.578)S(0.421)PVKGASFVTSTNPR 117.03 1.4914000000000003e-05 260420000.0 1317.0 1035.0 2131.3 2295.9 1575.6 1658.6 1153.4 1474.9 895.88 1127.8 True False 1347.6835375640972 913.8217188415541 1841.8811663928925 1894.9641643806224 1433.0872581947733 1641.915989888309 1066.3981093923328 1435.7808608496098 1520.2429275136597 1272.5641157022844 1.0590299702269672 0.7180948351174018 1.4473778913500335 1.4890913086409456 1.1261414969287435 1.2902422515522465 0.8379916549853555 1.128258170361225 1.1946297312294476 1.0 10.313522630216879 -7.222331406411424 24.99467184767393 1.0509076239545527 1.1895744702625357 0.09727858962438407 0.22005218106881508 1580.2590571833919 1009975.7666474001 0.09096134825342236 0.07045716648618051 5.99333555393168e-08 7.222331406411424 0.13866684630798298 LTTTGQVT(ph)SPVKGASFVTSTNPR ddPTM_A459_Selumetinib_30min_R2 1 LTTTGQVTSPVKGASFVTSTNPR 23 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTT(0.001)GQVT(0.499)S(0.499)PVKGASFVTSTNPR 84.89 0.00039786 106600000.0 47148.0 52062.0 44883.0 59328.0 59091.0 33779.0 30437.0 28000.0 18870.0 53327.0 True False 44527.702908398096 56054.9879942853 41995.27664491551 51247.42405349151 51667.46029975741 38431.75063476807 31852.380809771308 28081.47536435046 22644.527271852596 51787.310949814404 0.8598187874931104 1.0824077745339313 0.8109182708021262 0.9895749192915986 0.9976857139739668 0.7421074763277663 0.6150614933576786 0.5422462539436236 0.4372601484135131 1.0 15.660311028188389 -6.953621663255428 3.2832560531655353 0.613791568232347 0.9499395209300232 0.4560083992283095 0.15355500930217048 0.19653674842717705 4.361219862111248 0.05636421229667167 0.047343020056091915 1.112700637181596e-07 6.953621663255428 0.33614795269767617 LTTTGQVTS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 LTTTGQVTSPVK 12 0 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTTGQVT(0.136)S(0.864)PVK 210.64 5.778200000000002e-06 184250000.0 9333.5 11457.0 7555.9 8233.4 7606.7 7528.2 9212.8 8475.2 4490.5 8144.2 True False 9550.952390170467 10115.609113785209 6529.850281587794 6795.591250059421 6918.675328071961 7452.4731430587 8517.871078732165 8250.410164670571 7620.0505268563775 9189.587401225876 1.0393233094334993 1.1007685842822283 0.7105705617116959 0.7394881786697954 0.7528820420325968 0.8109692870503145 0.9269046265990022 0.8977998472020605 0.8292048591691805 1.0 13.16578437277399 -5.248812857187393 24.965647517622962 0.8261250777123892 1.070045983750087 0.5467348837788473 0.08595148668314981 567.541310014406 1122159.5607412453 0.02299786049425261 0.05996567742994096 5.638805865338821e-06 5.248812857187393 0.2439209060376979 LTTTGQVTS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 LTTTGQVTSPVK 12 0 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTTGQVT(0.21)S(0.79)PVK;LTTTGQVT(0.196)S(0.804)PVK 201.48 7.8669e-05 91927000.0 319700.0 287337.0 323170.0 327600.0 344790.0 289828.0 337623.0 319400.0 291431.0 267760.0 True False 301932.35386050027 309374.82396592386 302377.59404089215 282980.3148584787 301474.39773829136 329749.17620336794 353323.1384872827 320329.4011204837 349725.343262495 260029.07307597026 1.1611484450136371 1.1897701295713834 1.1628607157806132 1.0882641372020851 1.1593872722463323 1.2681242612706933 1.3587832095377104 1.231898407863401 1.344947082745317 1.0 17.98831341014302 -6.744646737227605 7.249631485630419 1.2627546978958275 1.1510498612559634 0.15754723785534253 0.09577676650471569 0.2217388405830744 53.44620300978407 0.0304218788311581 0.029405795933318626 1.8003347436510435e-07 6.744646737227605 -0.11170483663986408 LTTTGQVTS(ph)PVKGASFVTSTNPR ddPTM_A459_Selumetinib_30min_R1 1 LTTTGQVTSPVKGASFVTSTNPR 23 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LTTTGQVT(0.066)S(0.934)PVKGASFVTSTNPR 136.49 2.743e-06 208430000.0 1441.6 1125.3 2130.8 2406.2 1931.8 1488.8 1364.7 1405.8 841.6 1289.2 True False 1475.186475134702 993.5493528622231 1841.4490636465903 1986.0023399680533 1757.0690310869913 1473.8240237222437 1261.759580273726 1368.513617318044 1428.133731968005 1454.6813778714175 1.0140959371414302 0.683001355469366 1.2658779383985213 1.365249029910659 1.2078720865032635 1.0131593393178904 0.8673786572562117 0.9407651999508926 0.9817501988358036 1.0 10.506487475663052 -6.9946351437449 22.76743951416758 0.9422132194469406 1.1071725065746725 0.15938767802859 0.17349942879292704 99.93987109190905 424115.4475922865 0.06891764721452115 0.06051786995545993 1.0124296519599859e-07 6.9946351437449 0.1649592871277319 LTTTGQVTS(ph)PVKGASFVTSTNPR ddPTM_A459_Selumetinib_30min_R2 1 LTTTGQVTSPVKGASFVTSTNPR 23 1 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 LT(0.001)T(0.002)T(0.004)GQVT(0.275)S(0.717)PVKGAS(0.001)FVTSTNPR 73.60300000000002 0.00066218 98978000.0 96335.0 99744.0 98369.0 104900.0 113750.0 68699.0 55763.0 56913.0 47597.0 96501.0 True False 90981.08635955997 107394.0440724903 92040.04563606897 90612.43903740656 99459.70806209768 78161.66366256935 58356.08999228824 57078.60740754561 57117.729971296685 93714.76539029067 0.9708297937966781 1.145967165635319 0.9821296062872584 0.9668960772620625 1.0613024281486618 0.8340378737230163 0.6226989925147295 0.6090673883654544 0.6094848526101563 1.0 16.515988751629514 -6.965689062029568 3.423304159392568 0.6798214829900158 1.0260066449361505 0.6069126878099671 0.11881627233692865 0.1442523109055894 3.536211614996406 0.043689206071394295 0.03652397497872894 1.0822084932156138e-07 6.965689062029568 0.3461851619461347 LTTTSGVQDELHLPLNS(ph)PLPGSELTK ddPTM_A459_Selumetinib_30min_R2 1 LTTTSGVQDELHLPLNSPLPGSELTK 26 0 C9JVX2;Q9UL03-3;Q9UL03 C9JVX2 INTS6 Integrator complex subunit 6 1 LTTTSGVQDELHLPLNS(0.935)PLPGS(0.061)ELT(0.003)K 100.68 9.2531e-05 0.0 10932.0 17365.0 12608.0 12850.0 13456.0 9506.6 8845.6 10354.0 8997.6 17015.0 True False 10324.443204263345 18696.839662724517 11796.815006552462 11099.807832513581 11765.536981833711 10816.04785767744 9256.937927223877 10384.128425803021 10797.371413949168 16523.732739720814 0.6248251146936541 1.131514286586096 0.7139316032505487 0.6717494168754707 0.7120386880593242 0.6545765432090975 0.560220748727765 0.6284372054046229 0.653446263264338 1.0 14.012252010421504 -5.4958807828861405 24.73422217946362 0.6762446201538234 0.8893080661890983 0.1605932763444663 0.15857818615469055 839.6473283311645 769242.5158696654 0.0382743555916255 0.0792915952516262 3.192414076594758e-06 5.4958807828861405 0.21306344603527494 LTVAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 LTVASPK 7 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 LT(0.002)VAS(0.998)PK 89.029 0.031501 79476000.0 803280.0 831030.0 730170.0 689610.0 649410.0 474530.0 722850.0 625850.0 420080.0 710150.0 True False 758636.9133846194 894767.3288173896 683191.6571489864 595683.9283563974 567825.3100009395 539892.2001455483 756463.9573001019 627671.1198849552 504107.73801589006 689646.1243087114 1.1000379566332852 1.2974296487409218 0.9906408998293221 0.8637530283426157 0.823357501747896 0.7828539610611549 1.096887128972656 0.9101350645798543 0.7309658102134604 1.0 19.39549674115812 -5.458675142996192 4.2699779011194785 0.8865667962402071 1.19582174598626 0.5635298873011023 0.10835678001360158 0.1541736982681882 5.50144405100664 0.029362073539336946 0.0626323567316907 3.4779621952915146e-06 5.458675142996192 0.30925494974605283 LTVENS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 LTVENSPK 8 0 F8VVL1;O43583 F8VVL1 DENR Density-regulated protein 1 LT(0.023)VENS(0.977)PK;LT(0.122)VENS(0.878)PK;LT(0.005)VENS(0.995)PK 127.51 0.0045631 277465000.0 31632.9 43631.0 26199.7 24600.9 23476.9 27679.0 33252.8 32263.9 22118.4 37474.0 True False 32369.885023091378 38522.66223649839 22641.924644650622 20304.814631086403 21353.418540183346 27400.574390521208 30744.514524017148 31408.15656408282 37533.30933598042 42284.15292767104 0.7655323042289988 0.9110425435834827 0.5354706923745324 0.4801991579639471 0.504998139059551 0.6480104836767365 0.7270930690418945 0.7427878859914231 0.887644820511903 1.0 15.367829457167023 -8.233397351588264 1.2197824818624503 0.997097522690226 0.6390159263909635 0.4895184223712288 0.1213791555763591 0.4294874673145967 1.2518171896900063 0.12966923085687868 0.04206798240433336 5.842552834268694e-09 8.233397351588264 -0.3580815962992625 LTVENS(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 LTVENSPK 8 0 F8VVL1;O43583 F8VVL1 DENR Density-regulated protein 1 LT(0.003)VENS(0.997)PK;LT(0.015)VENS(0.985)PK;LTVENS(1)PK;LT(0.004)VENS(0.996)PK;LT(0.001)VENS(0.999)PK;LTVENS(1)PK 99.539 0.018569 558067000.0 1700460.0 1260280.0 1357470.0 1298720.0 1248370.0 1134928.0 1716120.0 1558480.0 1114167.0 1208687.0 True False 1605955.240680722 1356939.4235610992 1270131.858101584 1121832.0955830396 1091538.6000305992 1291254.0301493858 1795922.9804272698 1563014.9187797452 1337031.5324270388 1173789.065764028 1.3681804401844497 1.1560334502501581 1.0820784544238753 0.9557356839517248 0.9299273880355228 1.1000733162469007 1.5300219032610345 1.331597783936049 1.1390730851260358 1.0 20.16274174342997 -7.043369043037083 24.992611652190917 1.283126589341917 1.0849855957609518 0.14657810165326313 0.17035932228804024 725.9930082356616 418371.38143715647 0.06702100092757292 0.05191777096904963 9.049632788203003e-08 7.043369043037083 -0.19814099358096526 LTVENS(ph)PKQEAGISEGQGTAGEEEEK ddPTM_A459_Selumetinib_30min_R1 4 LTVENSPKQEAGISEGQGTAGEEEEK 26 1 F8VVL1;O43583 F8VVL1 DENR Density-regulated protein 1 LT(0.001)VENS(0.997)PKQEAGIS(0.002)EGQGTAGEEEEK;LT(0.004)VENS(0.993)PKQEAGIS(0.002)EGQGT(0.001)AGEEEEK;LT(0.014)VENS(0.981)PKQEAGIS(0.004)EGQGT(0.001)AGEEEEK;LT(0.012)VENS(0.978)PKQEAGIS(0.009)EGQGT(0.001)AGEEEEK 110.36 1.1382e-08 354500000.0 6993.1 11743.8 10075.2 11531.7 6583.400000000001 10223.2 8039.1 6961.3 5083.7 8393.4 True False 7156.025623796117 10368.8304364555 8707.043179112132 9517.905071818479 5987.932632393672 10120.363889922914 7432.704214683461 6776.663710510811 8626.667601242567 9470.774648639426 0.7555903175063038 1.0948238999589215 0.9193591339820326 1.0049764063582511 0.6322537336746683 1.0685888182733614 0.7848042520736406 0.7155342579589673 0.910872438769502 1.0 13.209266718385713 LTVENS(ph)PKQEAGISEGQGTAGEEEEK ddPTM_A459_Selumetinib_30min_R2 5 LTVENSPKQEAGISEGQGTAGEEEEK 26 1 F8VVL1;O43583 F8VVL1 DENR Density-regulated protein 1 LT(0.029)VENS(0.968)PKQEAGIS(0.002)EGQGT(0.001)AGEEEEK;LT(0.004)VENS(0.995)PKQEAGISEGQGTAGEEEEK;LT(0.04)VENS(0.933)PKQEAGIS(0.012)EGQGT(0.014)AGEEEEK;LT(0.064)VENS(0.934)PKQEAGIS(0.002)EGQGTAGEEEEK;LT(0.023)VENS(0.957)PKQEAGIS(0.004)EGQGT(0.015)AGEEEEK 69.528 0.00053048 239029100.0 191311.0 200873.0 184147.0 142787.0 125325.0 108909.4 122221.0 106984.8 69022.4 180053.0 True False 180678.700498612 216279.31319150407 172299.18250409426 123339.16427868641 109580.55308028468 123910.68126890116 127904.51867631686 107296.10805571295 82828.8086469908 174854.40205612386 1.0333094184304188 1.2369108849892372 0.9853865872292455 0.7053820940641669 0.6266959927329258 0.7086506248160052 0.7314915562449651 0.6136311513694325 0.4737015921418143 1.0 17.415794591573935 -5.661291244404526 3.079298877972879 0.674385985212048 1.1336781975104415 0.650186772582557 0.13377698669544996 0.13627284860164388 2.567655582591131 0.03627573434008198 0.06823488531633645 2.1812666310740476e-06 5.661291244404526 0.45929221229839357 LTVENS(ph)PKQEAGISEGQGTAGEEEEKK ddPTM_A459_Selumetinib_30min_R1 1 LTVENSPKQEAGISEGQGTAGEEEEKK 27 2 F8VVL1;O43583 F8VVL1 DENR Density-regulated protein 1 LT(0.082)VENS(0.889)PKQEAGIS(0.025)EGQGT(0.003)AGEEEEKK 40.104 0.038568 3891700.0 273.41 270.97 579.8 539.3 319.87 323.18 245.5 186.12 60.431 241.89 True False 279.77992103674995 239.24470642946451 501.06634461342793 445.12137891479136 290.93781497763524 319.92910262396185 226.9817373468161 181.1834929970368 102.54699329438981 272.9389377081267 1.0250641531254834 0.8765502952360215 1.8358184758132765 1.6308460150555426 1.0659447033121967 1.1721636542972302 0.8316209451564001 0.663824277028547 0.37571404855415214 1.0 8.092434415208409 -7.24553868967669 1.613697690114812 0.6368731554482019 1.3184572329781135 0.4552438589734018 0.30023546068848134 0.36497757854337526 1.8569136251656166 0.17925354737906402 0.10999429767818589 5.681477751376388e-08 7.24553868967669 0.6815840775299116 LTVNGVCAS(ph)TPPLTPIK ddPTM_A459_Selumetinib_30min_R2 2 LTVNGVCASTPPLTPIK 17 0 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 LTVNGVCAS(0.702)T(0.133)PPLT(0.166)PIK;LTVNGVCAS(0.843)T(0.156)PPLT(0.001)PIK 143.67 0.00049573 11103800.0 51991.0 44507.0 43516.0 55322.0 55496.0 48166.0 51761.0 66753.0 52525.0 64337.0 True False 49101.54835646319 47920.5437874391 40716.227936638425 47787.048164226966 48524.096339465184 54800.429292585344 54167.98906247572 66947.24017844595 63031.467671121245 62479.42364239895 0.7858835036234642 0.7669812074725975 0.6516741922857323 0.7648445740750778 0.7766412285937991 0.8770956276139111 0.8669732514260416 1.071508606763381 1.0088356133353906 1.0 15.931093524577228 -7.239711532414563 1.1257062647154383 1.03331577050891 0.738235519021821 0.8474808159090111 0.04944421982147592 0.17961823220667203 0.4449016265063568 0.033842102426854606 0.019604008095051105 5.7582228368823046e-08 7.239711532414563 -0.29508025148708894 LTVNGVCASTPPLT(ph)PIK ddPTM_A459_Selumetinib_30min_R2 1 LTVNGVCASTPPLTPIK 17 0 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 LTVNGVCAS(0.192)T(0.369)PPLT(0.439)PIK 146.18 0.00065763 0.0 13799.0 11253.0 9539.9 14117.0 11994.0 8663.2 12373.0 11267.0 11275.0 9360.4 True False 13032.106821773672 12116.06891590204 8926.113220257766 12194.24024681668 10487.206492279545 9856.47716330036 12948.369016634382 11299.785104647737 13530.315049821831 9090.140930760073 1.433652890647097 1.3328802059495632 0.9819554271213492 1.3414797789935977 1.1536901982225545 1.0843041090757004 1.4244409536950604 1.2430813989264415 1.488460426838563 1.0 13.150086946356778 -7.268572810144704 24.87905776539855 1.3092524601769222 1.2179042471738222 0.03018623904987494 0.1726504386923767 1744.7924973305444 6085230.06725533 0.06939315145627316 0.04784130639582815 5.387995072262523e-08 7.268572810144704 -0.09134821300310003 LTVVSPNRAT(ph)STETSSSVETDLQPFR ddPTM_A459_Selumetinib_30min_R1 1 LTVVSPNRATSTETSSSVETDLQPFR 26 1 Q14CZ0;A0A087X1J2 Q14CZ0 C16orf72 UPF0472 protein C16orf72 1 LT(0.001)VVS(0.006)PNRAT(0.43)S(0.43)T(0.13)ET(0.001)S(0.001)S(0.001)S(0.001)VETDLQPFR 54.12 0.016926 7429400.0 72.285 233.02 496.22 444.64 466.87 212.05 262.44 131.4 162.83 227.82 True False 73.96909985787454 205.73791007194095 428.83604954135126 366.99197092652145 424.64169093259324 209.91696952599526 242.6439395083439 127.91484515264682 276.31061736733614 257.0629161547211 0.28774706583252946 0.8003406837107199 1.668214365401672 1.427634823475029 1.6518978983223305 0.8165976355751382 0.9439087641964712 0.49760131514129946 1.0748754487832473 1.0 8.00597769205639 LTWHS(ph)CPEDEAQ ddPTM_A459_Selumetinib_30min_R1 4 LTWHSCPEDEAQ 12 0 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 LTWHS(1)CPEDEAQ;LTWHS(1)CPEDEAQ;LTWHS(1)CPEDEAQ;LTWHS(1)CPEDEAQ 142.12 0.00093539 159714000.0 15762.900000000001 17921.8 18999.9 20334.8 16504.7 16161.9 17481.8 15005.599999999999 8621.7 12336.8 True False 16130.144900735848 15823.507324381217 16419.81793898013 16783.708911471364 15011.852799141456 15999.325959831087 16163.133751322073 14607.602742941828 14630.395195946472 13920.348450608204 1.1587457711973506 1.136717761090949 1.1795550949920883 1.2056960334737925 1.0784107059105665 1.1493480940221759 1.1611156005664411 1.0493704805430784 1.0510078284216546 1.0 13.764907704361994 -7.809603470649114 4.903267356946984 1.034048366729322 1.1524261690837814 0.7323714000568715 0.03312964439979089 0.11023241995740377 5.703362925303685 0.019136137579863797 0.009128841514727308 1.550231400201697e-08 7.809603470649114 0.11837780235445927 LTWHS(ph)CPEDEAQ ddPTM_A459_Selumetinib_30min_R2 4 LTWHSCPEDEAQ 12 0 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 LTWHS(1)CPEDEAQ;LTWHS(1)CPEDEAQ;LTWHS(1)CPEDEAQ;LTWHS(1)CPEDEAQ 143.31 0.00083639 221348000.0 280578.0 259703.0 282673.0 284194.0 299314.0 216177.0 192664.0 223273.0 198080.0 245496.0 True False 264984.59800272563 279621.3850232384 264486.1269310914 245486.28693800548 261711.49941888978 245953.4194905789 201623.25775647326 223922.68746516522 237701.53481762327 238407.8926047894 1.1114757783711156 1.1728696645407162 1.1093849454452924 1.029690268454954 1.0977467925222213 1.0316496522130574 0.8457071431385272 0.9392419228182332 0.9970371879074613 1.0 17.863072472121566 -6.992984077106173 4.210151975587812 0.9392954943422982 1.1027220397488204 0.6766021740454693 0.05149961414152916 0.12617158328507266 5.334836546671301 0.020562076964247854 0.017059925131960082 1.0162859531108241e-07 6.992984077106173 0.16342654540652224 LTWSPGS(ph)VTNTSLAHELWK ddPTM_A459_Selumetinib_30min_R1 2 LTWSPGSVTNTSLAHELWK 19 0 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H7C269;H3BRT3 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 LT(0.065)WS(0.178)PGS(0.707)VT(0.046)NT(0.003)S(0.001)LAHELWK;LT(0.006)WS(0.135)PGS(0.858)VT(0.001)NTSLAHELWK 144.95 3.5719e-05 11875000.0 3836.2 4017.0 5040.7 5936.9 5812.4 4316.8 4894.7 3644.3 2093.3 3615.2999999999997 True False 3925.5759960542064 3546.687772547366 4356.200626583146 4900.131864415404 5286.669446262569 4273.376911340798 4525.488838254422 3547.6413256452875 3552.177211417091 4079.358971004135 0.9623021714825761 0.8694228180841727 1.0678640094060823 1.201201438570442 1.2959559293114267 1.047560889275921 1.1093627382197435 0.869656568804494 0.8707684802111744 1.0 11.994126750091285 -7.76026692969185 24.99912271189358 0.902659365228556 1.0824236678140438 0.30026939759834526 0.11542844861695255 41.278238626389324 880208.3363754482 0.06556197944082497 0.035099549408635196 1.736733055304808e-08 7.76026692969185 0.1797643025854877 LVAGEMGQNEPDQGGQR ddPTM_A459_Selumetinib_30min_R1 1 LVAGEMGQNEPDQGGQR 17 0 Q5H928;Q99714-2;Q99714 Q5H928 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 139.76 0.011971 0.0 1009.0 883.1 1175.9 1153.4 1115.7 1054.1 1048.7 992.24 554.23 826.96 False True 1032.5077368277712 779.7062414579477 1016.2192387563477 951.9803419994822 1014.785131992833 1043.4967110462226 969.5957146867864 965.9225719502455 940.4878306423805 933.108371272531 1.1065249960405819 0.8356009499674937 1.0890688263470125 1.0202248434457988 1.0875319129426682 1.1183017355456246 1.0391030072578769 1.0351665483752588 1.0079084697951919 1.0 9.865900835286963 LVDVS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 1 LVDVSPDR 8 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 LVDVS(1)PDR 131.52 0.0035481 10974000.0 22599.0 17770.0 22216.0 23131.0 24482.0 19084.0 19186.0 23435.0 20077.0 19680.0 True False 21343.03805096482 19132.901860444257 20786.646746951912 19980.517896799356 21406.352288143054 21712.64777269646 20078.18701633776 23503.191970126896 24092.96099825036 19111.78726521924 1.1167473640629173 1.0011047943832778 1.0876348956008253 1.0454552271603128 1.1200602011251768 1.1360867234123317 1.0505656398173304 1.2297746748625333 1.2606335903547938 1.0 14.222175079795734 -6.837086908679066 1.0090340534098705 1.1616621467189674 1.0591845764118273 0.14304586792829088 0.07731314940120639 0.8350029772110408 1.8076586512206552 0.045294657185535936 0.038178678169440185 1.4551678510688344e-07 6.837086908679066 -0.10247757030714011 LVDVS(ph)PDRGSPPSR ddPTM_A459_Selumetinib_30min_R1 3 LVDVSPDRGSPPSR 14 1 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 LVDVS(0.997)PDRGS(0.003)PPSR;LVDVS(1)PDRGSPPSR;LVDVS(1)PDRGSPPSR 149.82 0.0020543 52387700.0 8169.5 9851.5 11993.5 13504.9 11299.0 10733.0 10348.8 10090.099999999999 6584.0 9076.4 True False 8359.833454920188 8698.0818001619 10364.84857557977 11146.522733369871 10277.007445000476 10625.035764784283 9568.181684133326 9822.477770736083 11172.567123666046 10241.444351622808 0.8162748502944832 0.849302256745031 1.012049494165089 1.088374095554564 1.0034724685461025 1.0374548159411414 0.9342609651164291 0.9590910650390502 1.0909171343488966 1.0 13.322131572619812 -5.232370052541942 4.530399270164446 1.0147895454880211 0.8265349497542215 0.7112952986792875 0.046760405823696914 0.10829287535719191 5.582901498071411 0.0126941840169335 0.03418676734692248 5.8563894210995865e-06 5.232370052541942 -0.18825459573379966 LVDVS(ph)PDRGSPPSR ddPTM_A459_Selumetinib_30min_R2 1 LVDVSPDRGSPPSR 14 1 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 LVDVS(0.912)PDRGS(0.025)PPS(0.063)R 174.24 0.0004249 18171000.0 35777.0 29701.0 37901.0 53975.0 46274.0 23203.0 23293.0 27440.0 23329.0 35105.0 True False 33788.65756667853 31978.97119623272 35462.49092348866 46623.51188793157 40460.64642519127 26399.0026341373 24376.170654203866 27519.845857063458 27995.451866722262 34091.427436256185 0.99111888552793 0.9380355591160472 1.0402172507970244 1.3676022212653827 1.186827582999984 0.7743589699638684 0.7150234674034166 0.807236537939627 0.821187435435723 1.0 15.05712138712628 -6.7672484100187695 24.974382112226312 0.8047299047068669 1.1065144279954415 0.538192283126153 0.12964986058962846 114.82451819027578 493654.19231881597 0.04945884248101894 0.044787756652690136 1.7090374913047624e-07 6.7672484100187695 0.30178452328857464 LVEALCAEHQINLIK ddPTM_A459_Selumetinib_30min_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 170.26 7.552399999999999e-05 11275000.0 3081.4 3594.9 4055.1 4279.4 3621.6 3000.8 3418.3 3248.9 2075.9 2520.1 False True 3153.1906246393373 3174.0074367763327 3504.4396930698745 3532.083124286964 3294.0269194454117 2970.6146765084027 3160.45487891088 3162.728618085497 3522.6506822628094 2843.579382852744 1.1088808153743133 1.1162014522668595 1.2324043823788524 1.2421257326544186 1.1584086378277116 1.04467443195773 1.11143543168478 1.1122350362916809 1.2388086309476634 1.0 11.473492364545478 -6.539696617637146 24.28510950867068 1.1082340944782187 1.1779985933388901 0.20176415288382155 0.06964111524869593 309.01653663962173 446217.3214270399 0.023582399447550507 0.023589007092281646 2.8860468867171416e-07 6.539696617637146 0.06976449886067138 LVEALCAEHQINLIK ddPTM_A459_Selumetinib_30min_R2 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 101.45 0.017541 0.0 19674.0 23381.0 17864.0 25298.0 25512.0 27526.0 7536.3 17014.0 18971.0 25902.0 False True 18580.597841262083 25174.24751823563 16714.64968885257 21852.36875851584 22306.95447982624 31317.45664385049 7886.752882895152 17063.507923180678 22765.730094028368 25154.141958521803 0.7386695150206579 1.0007992941976307 0.6644889623511855 0.8687383888724785 0.8868103915692905 1.245021861429094 0.31353694735046417 0.6783577810492497 0.9050489629727051 1.0 14.618508357751743 -8.521801726860904 22.045027097563594 1.0000000437026644 0.8047522408587927 0.0737133007133336 0.2289996268946808 52.71267359244691 1078894.4540264467 0.22369971730152297 0.05775901863694552 3.0074490123565486e-09 8.521801726860904 -0.19524780284387167 LVEDEERR ddPTM_A459_Selumetinib_30min_R1 1 LVEDEERR 8 1 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 118.74 0.01112 4969800.0 2371.2 2796.1 3428.4 3585.0 2646.1 2576.4 2096.1 2791.2 1271.3 1815.7 False True 2426.4443464479796 2468.7313121283755 2962.842110853185 2958.9470487845883 2406.7607222069005 2550.4837551840337 1937.989489420209 2717.1683089046264 2157.3032479217245 2048.762781415708 1.1843461666027002 1.2049864115661386 1.4461616238488295 1.4442604461703161 1.1747386003097018 1.2448897345849055 0.9459316163880359 1.3262483746542124 1.0529785427042042 1.0 11.00053723441515 -6.730596410749666 2.1233259737895414 1.11238436613341 1.315844572126651 0.3550429973532967 0.13078974436423552 0.38612693510246804 3.579291764533553 0.0518285181751919 0.04869501035875553 1.8595317125998012e-07 6.730596410749666 0.20346020599324088 LVEDEERR ddPTM_A459_Selumetinib_30min_R2 1 LVEDEERR 8 1 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 95.815 0.0292 4292600.0 23064.0 13521.0 23739.0 23400.0 24888.0 17659.0 12302.0 16028.0 12713.0 23481.0 False True 21782.195212507282 14558.017223132641 22211.658585068915 20212.879632748485 21761.34693845701 20091.36695755853 12874.067375950544 16074.638826421768 15255.955230898891 22803.042519035214 0.9552319693446274 0.6384243335502312 0.9740655689488527 0.8864115223166142 0.9543176933644433 0.8810827301131825 0.5645767386173887 0.7049339496255028 0.6690315653344825 1.0 14.476938709828897 -7.215659468136594 23.69792008924542 0.7100466966520131 0.8782646853247561 0.2101797359571801 0.1361713467366549 315.79814291977294 163472.41008986387 0.04993764855068235 0.03868128692123105 6.086120291130441e-08 7.215659468136594 0.16821798867274296 LVEPHS(ph)PSPSSK ddPTM_A459_Selumetinib_30min_R1 3 LVEPHSPSPSSK 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 LVEPHS(0.993)PS(0.005)PS(0.002)SK;LVEPHS(0.978)PS(0.022)PS(0.001)SK;LVEPHS(0.985)PS(0.015)PSSK 225.79 2.3284000000000004e-09 126355000.0 16571.1 17603.2 18302.0 20456.100000000002 18994.300000000003 15507.5 17654.6 15932.9 7651.9 12671.7 True False 16957.174388252402 15542.209160494336 15816.68892568982 16883.82614355437 17276.268918716047 15351.508629683436 16322.8993082 15510.307734646938 12984.715427335988 14298.236127810445 1.185962676561919 1.0870018526456093 1.106198609696055 1.180832795921931 1.2082797321491459 1.0736645060592018 1.1416023041087937 1.0847707084987204 0.9081340741100488 1.0 13.803549562454036 -8.090923646729092 3.978911032284427 0.9563551514156967 1.1377630984464155 0.715307455256269 0.046290860291573865 0.12606695544679994 3.507643003082842 0.03475220857845813 0.012211725228313685 8.111036453728607e-09 8.090923646729092 0.18140794703071883 LVEPHS(ph)PSPSSK ddPTM_A459_Selumetinib_30min_R2 3 LVEPHSPSPSSK 12 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 LVEPHS(0.682)PS(0.317)PS(0.001)SK;LVEPHS(0.972)PS(0.018)PS(0.005)S(0.005)K;LVEPHS(0.997)PS(0.002)PSSK 120.21 0.0027046 184375000.0 422800.0 392020.0 493180.0 537880.0 529380.0 387760.0 414960.0 430000.0 352460.0 483760.0 True False 399302.4686025015 422086.6734570266 461449.3357337847 464619.81610524526 462874.55168275355 441170.42026518425 434256.4622276412 431251.2288096677 422961.84855522786 469792.5918405724 0.8499548003473153 0.8984532340183534 0.9822405541260236 0.9889892351961936 0.985274267244796 0.9390748767168697 0.9243578331584448 0.9179608965737288 0.9003161307804596 1.0 18.841664438108047 -5.007202310263604 3.7979562520274674 0.9523423558959069 0.8550002757543977 0.518987703282437 0.03249815704219103 0.1895145069184287 5.9952489811668155 0.009236049976220816 0.037700146600760286 9.835528241265505e-06 5.007202310263604 -0.09734208014150914 LVEQANS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 LVEQANSPK 9 0 O95391 O95391 SLU7 Pre-mRNA-splicing factor SLU7 1 LVEQANS(1)PK;LVEQANS(1)PK;LVEQANS(1)PK;LVEQANS(1)PK 140.78 0.0022636 340495500.0 24641.300000000003 27499.3 27441.9 27527.399999999998 19591.9 22051.7 23489.7 22567.899999999998 16642.6 22163.899999999998 True False 25215.394346376772 24279.669171922276 23715.440707566806 22720.256343295074 17819.816104230886 21829.879919341627 21717.853017334022 21969.325981129517 28241.276672588767 25008.85245966825 1.0082587510579148 0.9708429929393231 0.9482818432318184 0.9084885593985572 0.7125403347862076 0.8728861092105945 0.8684066193104374 0.8784619772762235 1.1292512008751079 1.0 14.61015123999804 -10.184181975275592 16.80281670689068 0.9999999995656155 0.913298929423874 0.04368236118000446 0.10265337623994701 0.0 0.0 0.10360436551716687 0.025127749547198774 6.54361930095505e-11 10.184181975275592 -0.08670107014174144 LVEQANS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 LVEQANSPK 9 0 O95391 O95391 SLU7 Pre-mRNA-splicing factor SLU7 1 LVEQANS(1)PK;LVEQANS(1)PK;LVEQANS(1)PK;LVEQANS(1)PK 115.92 0.0080137 444844000.0 907160.0 909110.0 822080.0 757790.0 598963.0 533066.0 757130.0 588551.0 463494.0 669050.0 True False 856743.6788492078 978835.8137506176 769188.2678130293 654577.6947393368 523715.9131428404 606491.002808647 792338.0452246334 590263.5859701363 556205.751104401 649732.7880993349 1.3186092722139549 1.5065205753491502 1.183853242289246 1.0074567679648347 0.806048152002407 0.9334468167795822 1.2194829316563538 0.9084712927861252 0.8560530748824777 1.0 19.309486985585025 -5.56664021103943 2.7589663671412117 0.9592493865648929 1.410731205848511 0.7183855377616271 0.1133828273070976 0.1425513714531491 2.1827422250476833 0.03359709896951458 0.07096638392515339 2.7124378060638415e-06 5.56664021103943 0.4514818192836182 LVES(ph)PKEGK ddPTM_A459_Selumetinib_30min_R2 1 LVESPKEGK 9 1 Q96S94;Q96S94-3 Q96S94 CCNL2 Cyclin-L2 1 LVES(1)PKEGK 115.29 0.038996 4190100.0 31197.0 35364.0 24208.0 21125.0 19528.0 17485.0 16168.0 18704.0 7187.9 23803.0 True False 29463.195631485876 38076.30508681774 22650.483635677527 18247.73855734236 17074.718057464976 19893.400036973275 16919.84403628422 18758.425543386104 8625.680846706371 23115.745542378754 1.2745942187964545 1.6472021210395902 0.9798725113214173 0.7894073121668631 0.738661793372029 0.860599542441845 0.7319618571360629 0.8114999150252692 0.37315174762123354 1.0 14.496588273507562 -5.452975184767447 3.617826117351841 0.7563523570501136 1.457071695570507 0.719951113551591 0.17263325195267404 0.11188822930997856 2.815481898229124 0.04475598749898524 0.09847967079301578 3.5239100580195606e-06 5.452975184767447 0.7007193385203934 LVETTMVPS(ph)PEAK ddPTM_A459_Selumetinib_30min_R2 5 LVETTMVPSPEAK 13 0 Q16236-3;Q16236-2;Q16236;C9J0Y1;K7EIW5;C9J1A8 Q16236-3 NFE2L2 Nuclear factor erythroid 2-related factor 2 1 LVETTMVPS(1)PEAK;LVETT(0.002)MVPS(0.998)PEAK;LVETT(0.114)MVPS(0.886)PEAK;LVETT(0.005)MVPS(0.995)PEAK;LVETT(0.024)MVPS(0.976)PEAK 190.27 0.00016249 12941300.0 165519.0 114464.0 129764.0 150212.0 155074.0 143479.0 206950.0 206233.0 177321.0 126972.0 True False 156320.11660505517 123243.02074023026 121415.12551636084 129752.86646984659 135592.21774085035 163241.92987731702 216573.58506364553 206833.10388628874 212790.1547627013 123305.98844712465 1.2677414825808517 0.9994893378035619 0.9846652789975838 1.0522835760364262 1.0996401671034348 1.3238767389413326 1.7563914599047665 1.6773970712296888 1.7257081950561446 1.0 16.911883341437694 -6.96425418856603 3.162407244132833 1.5949656336455615 1.0690026133002013 0.4958754691647067 0.2146011786678507 0.17934892431145155 3.6947492629648715 0.07935208555095677 0.06601198128904723 1.0857899347410468e-07 6.96425418856603 -0.5259630203453602 LVGATATS(ph)SPPPK ddPTM_A459_Selumetinib_30min_R1 1 LVGATATSSPPPK 13 0 H9KVD1;Q96QD9-4;Q96QD9 H9KVD1 FYTTD1 UAP56-interacting factor 1 LVGAT(0.004)AT(0.087)S(0.543)S(0.366)PPPK 107.97 0.006437100000000001 4621000.0 2742.0 4015.9 3772.7 3657.7 3341.7 3611.2 3157.9 2894.0 1901.1 2559.5 True False 2805.8832649967776 3545.716561058742 3260.3880619577085 3018.9513585326026 3039.4438250250532 3574.8746067072593 2919.6970605601227 2817.241718963166 3226.0278491496842 2888.036756641245 0.9715538621675954 1.2277255657862096 1.1289288664558077 1.0453299638899367 1.0524256029760137 1.2378217134828986 1.010962569588518 0.9754867947870536 1.1170314372665808 1.0 11.49587338848225 LVGATATSS(ph)PPPK ddPTM_A459_Selumetinib_30min_R1 2 LVGATATSSPPPK 13 0 H9KVD1;Q96QD9-4;Q96QD9 H9KVD1 FYTTD1 UAP56-interacting factor 1 LVGATAT(0.002)S(0.014)S(0.983)PPPK;LVGATAT(0.003)S(0.029)S(0.967)PPPK 184.98 0.00012476 77253000.0 10207.2 12998.4 12393.599999999999 14245.5 11827.599999999999 10790.3 10576.3 9542.3 5754.5 9062.4 True False 10445.007900246203 11476.541285207784 10710.617193171758 11757.790846153646 10757.795668332385 10681.759378808518 9778.52117597202 9289.207206241263 9764.966207949 10225.647315251263 1.021451999881491 1.1223290742768772 1.0474268144567411 1.1498334025873584 1.0520405541747404 1.0446047129825196 0.9562740503858014 0.9084224127685955 0.9549484650604789 1.0 13.319904552686504 -7.12687021019829 2.242780784235994 0.9447876661879291 1.0834097541627643 0.6746347910094381 0.0405462737868121 0.16642703347671536 1.6422036680882766 0.017555352837623734 0.012651573093537753 7.466718694981161e-08 7.12687021019829 0.13862208797483522 LVGATATSS(ph)PPPK ddPTM_A459_Selumetinib_30min_R2 2 LVGATATSSPPPK 13 0 H9KVD1;Q96QD9-4;Q96QD9 H9KVD1 FYTTD1 UAP56-interacting factor 1 LVGATAT(0.004)S(0.026)S(0.97)PPPK;LVGATATS(0.003)S(0.997)PPPK 182.37 0.00011058 49508000.0 110568.0 97958.0 108017.0 103536.0 99680.0 80347.0 82237.0 85770.0 67739.0 99408.0 True False 104423.07319877317 105471.06361538522 101067.30382001736 89434.21819043803 87157.3072494935 91414.06993255313 86061.18344952415 86019.57650001203 81288.69278579876 96537.83274699785 1.0816803135869086 1.092536061916774 1.0469191294659592 0.9264162623665204 0.9028305770848573 0.9469248203668208 0.891476232691794 0.8910452415629465 0.8420397524236599 1.0 16.558806818510803 -5.716778333913661 2.85112653672149 0.9074485974172161 1.0856855997242538 0.7829393079897864 0.03881548128722103 0.10868058605119654 1.794098500599016 0.010963960740228415 0.020119071940412337 1.919648288800687e-06 5.716778333913661 0.17823700230703776 LVGIISS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 LVGIIS(0.034)S(0.966)R;LVGIIS(0.046)S(0.954)R 88.177 0.031435000000000005 9887300.0 60362.0 53385.0 55792.0 58799.0 72063.0 50382.0 50245.0 60823.0 52383.0 49988.0 True False 57007.32168823121 57479.45784016975 52202.4034617366 50790.474766067404 63009.80168860599 57321.66317774019 52581.492058578726 60999.98486021028 62861.06370330972 48544.716555578256 1.1743259768128262 1.1840517757346922 1.0753467558507772 1.0462616401914306 1.2979744482896884 1.1808012744726466 1.083155815697859 1.2565730977205756 1.2949105106287078 1.0 15.567026665639865 -6.24603735016481 24.978192924515785 1.1930387903271666 1.1213826533702296 0.10038846898438625 0.09455519118962537 1866.8502280156476 3027560.805339806 0.02804987765388568 0.0360576256375272 5.674957975743952e-07 6.24603735016481 -0.07165613695693707 LVGIT(ph)SWGEGCARREQPGVY(ph)T(ph)K ddPTM_A459_Selumetinib_30min_R2 1 LVGITSWGEGCARREQPGVYTK 22 2 H0YAC1;P03952 H0YAC1 KLKB1 Plasma kallikrein;Plasma kallikrein heavy chain;Plasma kallikrein light chain 3 LVGIT(0.827)S(0.173)WGEGCARREQPGVY(1)T(1)K 50.397 0.04762 0.0 2501.8 3111.8 2495.9 2702.0 2525.1 2667.0 2460.5 1012.3 0.0 2953.6 True False 2362.7599714989055 3350.4650539859585 2335.3165113304503 2333.982938790017 2207.874363319583 3034.355041384482 2574.9181253882566 1015.245625404713 0.0 2868.321893625589 0.8237429616075455 1.168092417183671 0.8141751860278784 0.8137102547579966 0.7697442773861084 1.0578851167743328 0.8977089116499171 0.35395107768794803 0.0 1.0 11.485991222327545 -7.75865839607542 24.350362860628866 0.38273152377880876 0.9099533361971665 0.388423054952978 0.25739631667834717 43.60756151638115 381844.94397348614 0.12116910457825045 0.0658835347269475 1.7431774690550487e-08 7.75865839607542 0.5272218124183576 LVGLNLS(ph)PPMSPVQLPLR ddPTM_A459_Selumetinib_30min_R1 2 LVGLNLSPPMSPVQLPLR 18 0 Q8N0Z3 Q8N0Z3 SPICE1 Spindle and centriole-associated protein 1 1 LVGLNLS(0.997)PPMS(0.003)PVQLPLR;LVGLNLS(0.959)PPMS(0.041)PVQLPLR 227.41 1.1318e-18 22932100.0 3071.61 3961.3999999999996 4111.5 4308.63 3825.17 3409.26 3546.43 3399.97 1842.0700000000002 2841.71 True False 3143.1725366873625 3497.597446395105 3553.180882852895 3556.208653502018 3479.1840488886155 3374.9659397604073 3278.919929852826 3309.7917509409804 3125.8582505303016 3206.471159099428 0.9802591012763565 1.0907933590699888 1.108128127948247 1.1090723967406018 1.0850507851958293 1.052548353719889 1.0225945493218613 1.0322225233644613 0.9748593065182076 1.0 11.646770715442548 -7.428094535127268 1.3122435902852299 0.996039401864671 1.0788566632834684 0.4438297944164794 0.036265212848880624 0.4318997211289156 1.4207614017955141 0.026054070744136328 0.013088693582034084 3.731689193444921e-08 7.428094535127268 0.08281726141879742 LVGLNLS(ph)PPMSPVQLPLR ddPTM_A459_Selumetinib_30min_R2 1 LVGLNLSPPMSPVQLPLR 18 0 Q8N0Z3 Q8N0Z3 SPICE1 Spindle and centriole-associated protein 1 1 LVGLNLS(0.666)PPMS(0.334)PVQLPLR 122.5 0.00090814 56235000.0 62518.0 50769.0 53714.0 69381.0 63385.0 89292.0 62968.0 54942.0 74635.0 67102.0 True False 59043.49983938304 54662.81905193556 50258.09971938127 59931.18811109916 55422.00963091035 101591.16248792765 65896.13676872503 55101.87212386225 89564.08547613774 65164.59090806619 0.9060672217321406 0.8388423573325817 0.771248603252725 0.9196894705538736 0.850492711741249 1.5589933286200146 1.0112261252693338 0.8455799592389008 1.3744287231465047 1.0 15.9918006262457 -6.619809068516054 20.692579939217513 1.1465214812332234 0.8546316994027223 0.380818952954623 0.19145311883065658 4.777380532010023 1011.2862291581098 0.0628120305732783 0.06281190829171902 2.399887764158563e-07 6.619809068516054 -0.29188978183050107 LVHDS(ph)LEDLQMTR ddPTM_A459_Selumetinib_30min_R1 2 LVHDSLEDLQMTR 13 0 A0A087WYY3;A0A2R8Y635;A0A2R8YDN7;Q9H7F0-2;Q9H7F0 A0A087WYY3 ATP13A3 Probable cation-transporting ATPase 13A3 1 LVHDS(1)LEDLQMTR;LVHDS(1)LEDLQMTR 170.48 0.00014992 12491400.0 8031.900000000001 5807.9 9890.1 6445.0 10042.1 7692.9 8537.6 9482.1 3507.8999999999996 7759.4 True False 8219.027642643181 5127.908367980543 8547.078742430609 5319.501737633659 9133.793828076756 7615.516410594332 7893.601958338809 9230.603905798416 5952.650093120918 8755.394572956466 0.9387386912327165 0.5856855822145984 0.9762071453445057 0.6075684760187117 1.0432189836753998 0.8698084760356807 0.9015700997326209 1.0542761755489318 0.6798837041002557 1.0 13.095956481667056 -6.274059359527617 24.786613574470874 0.9235963435837956 0.777606589167102 0.18473396764340655 0.15203646069006363 1147.8884789941358 2254536.749844023 0.04355853986744655 0.049721114060838054 5.320355354866096e-07 6.274059359527617 -0.1459897544166936 LVHDS(ph)LEDLQMTR ddPTM_A459_Selumetinib_30min_R2 4 LVHDSLEDLQMTR 13 0 A0A087WYY3;A0A2R8Y635;A0A2R8YDN7;Q9H7F0-2;Q9H7F0 A0A087WYY3 ATP13A3 Probable cation-transporting ATPase 13A3 1 LVHDS(1)LEDLQMTR;LVHDS(1)LEDLQMTR;LVHDS(1)LEDLQMTR;LVHDS(1)LEDLQMTR 173.19 0.00010316 11807100.0 69296.0 26231.1 53935.2 58693.4 41446.1 35028.4 75196.0 59319.9 44916.7 41894.0 True False 65444.80573386693 28242.941023719723 50465.06795220565 50699.25766823757 36239.270385164855 39853.2441438441 78692.76299804726 59492.51108806189 53901.29507745744 40684.4113663158 1.6085965984517407 0.6941956409157525 1.2404030501468097 1.246159301943679 0.8907409292191149 0.9795703761082346 1.9342239534820957 1.462292536382081 1.3248635845346017 1.0 15.312188497074759 -7.202192088914853 24.999590900452116 1.468874477114216 1.0932042775250423 0.19574368321193147 0.31320609050845505 350.49527262780487 147892.5336058084 0.1147783121869012 0.08890687046401574 6.277806293525641e-08 7.202192088914853 -0.3756701995891736 LVHSGS(ph)GCRSPSLGSDLTFATR ddPTM_A459_Selumetinib_30min_R1 1 LVHSGSGCRSPSLGSDLTFATR 22 1 Q13425 Q13425 SNTB2 Beta-2-syntrophin 1 LVHS(0.106)GS(0.445)GCRS(0.445)PS(0.004)LGSDLTFATR 75.319 0.00078862 31192000.0 1255.5 1525.0 1765.0 2286.5 2459.4 1395.1 1281.0 1196.2 499.56 517.76 True False 1284.7507072222652 1346.4522910467333 1525.3226944510186 1887.2056979207705 2236.947704242338 1381.0665606494504 1184.3731386609832 1164.472890194796 847.7168335811986 584.2195394094822 2.199088905038791 2.3047025993134382 2.61087244016656 3.230302259024615 3.8289505114864895 2.363951335906029 2.0272740960669076 1.9932111332185547 1.4510244461149902 1.0 9.190366800146121 -7.880142696111742 1.1020857035892555 1.1209744195369475 2.793503094701725 0.6258643285880825 0.46956447959613473 0.3756880218813312 0.8247340031389901 0.47604321347538636 0.178106246663748 1.3178236701698007e-08 7.880142696111742 1.6725286751647774 LVHT(ph)SPNYR ddPTM_A459_Selumetinib_30min_R2 1 LVHTSPNYR 9 0 Q15751;H0YNB1 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 LVHT(0.98)S(0.02)PNYR 106.16 0.018072 2101100.0 5651.1 5350.4 5286.7 7613.7 8971.7 6619.4 6550.6 5497.0 5059.4 6570.0 True False 5337.034485145679 5760.7584757524455 4946.559477723739 6576.700925634915 7844.594837984357 7531.162265069536 6855.21587976765 5512.995359922663 6071.421371447325 6380.307029089961 0.8364855266074732 0.9028967492453285 0.7752854925586988 1.0307812610975502 1.2295011513110914 1.180376152861052 1.074433541914585 0.864064273833072 0.9515876498992412 1.0 12.639410134778824 -5.834925572298829 6.772928824515445 1.0572786590205518 0.8453258303464396 0.4636274827333874 0.10273869286168379 0.21134648422159774 15.690881251039272 0.03317177675295406 0.04976445015073702 1.4624277781737757e-06 5.834925572298829 -0.21195282867411225 LVIGDHK ddPTM_A459_Selumetinib_30min_R1 1 LVIGDHK 7 0 O00193;E9PM92;E9PRZ9 O00193 SMAP;C11orf58 Small acidic protein 0 120.49 0.013186000000000002 6239200.0 5605.4 6983.9 7583.0 7867.4 7178.5 7001.3 6475.9 6189.7 4117.9 6247.9 False True 5735.994913790272 6166.221741272972 6553.270250437436 6493.506279388525 6529.205942467111 6930.873278671775 5987.417649222998 6025.5290490208345 6987.775540483657 7049.878824699675 0.813630284494234 0.8746564153229476 0.9295578567219708 0.9210805520001473 0.9261444210348191 0.9831194905633048 0.8492936968286207 0.8546996620580245 0.9911908721042928 1.0 12.783382744938445 -1.5228791160864712 0.017456099086516807 1.646980394202179 4.45034175306985e-06 0.34270010069785284 0.04990888696180399 5811.090715089471 7.854551717040535 285.6566810800848 478.2837121657 0.029999974385630665 1.5228791160864712 -1.646975943860426 LVIGDHK ddPTM_A459_Selumetinib_30min_R2 2 LVIGDHK 7 0 O00193;E9PM92;E9PRZ9 O00193 SMAP;C11orf58 Small acidic protein 0 ; 138.24 0.004138899999999999 13688400.0 142424.0 124160.0 134610.0 151092.0 150916.0 123999.0 126188.0 117022.0 109675.0 139969.0 False True 134508.64424844526 133682.6727626761 125949.33915228657 130513.00895176193 131956.58287384204 141078.7366991505 132055.9920367783 117362.51464596491 131613.0645755395 135927.7312868634 0.9895599887897542 0.9834834400388154 0.9265904606800337 0.9601646971972616 0.970784854750201 1.0378951768231632 0.9715161931018026 0.863418476383467 0.9682576419802212 1.0 17.05248029190094 LVIIT(ph)AGAR ddPTM_A459_Selumetinib_30min_R2 2 LVIITAGAR 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GYU2;F5GXY2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 LVIIT(1)AGAR;LVIIT(1)AGAR 125.68 0.011659 5320100.0 17676.2 19466.6 22562.0 21379.0 22637.0 13121.9 16334.8 17688.0 15612.0 17343.5 True False 16693.827567435023 20959.625625015433 21110.385483648217 18467.14331916793 19793.13768265233 14929.32261625162 17094.400566792156 17739.46915159397 18734.836235726696 16842.748091175305 0.9911581813766894 1.2444302741781879 1.2533812991425624 1.096444785565826 1.1751726960176334 0.8863946985037308 1.0149412954616772 1.0532407808728375 1.1123384458586507 1.0 14.039839929714615 -6.722832514953596 24.999174065923704 1.0168078238135212 1.159778904452412 0.3848322169662325 0.08738161657259183 172.04101864795945 111401.55478343478 0.02926084753230628 0.02926033674044775 1.8930735389949541e-07 6.722832514953596 0.14297108063889086 LVINGNPIT(ph)IFQERDPSK ddPTM_A459_Selumetinib_30min_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 LVINGNPIT(1)IFQERDPSK 98.562 0.0044878 10906000.0 2178.1 2189.0 2283.6 2254.2 1898.7 1705.2 1396.7 2221.8 1493.5 1333.3 True False 2228.8454921551706 1932.7108623615088 1973.499662916911 1860.5462865746774 1726.962920242712 1688.0472361977234 1291.3457945103796 2162.8706465764903 2534.360419075827 1504.4420424417929 1.4815097087672655 1.28466953716915 1.3117817817121167 1.2367018695880818 1.1479092391221368 1.122042051854606 0.8583552959038913 1.4376563440529961 1.684584947494833 1.0 10.555012813604927 -4.146899550751272 0.9874167582527686 1.2139159041983185 2.0896072256213274 0.11838357236223707 0.21516531712206582 14.327643918178898 4.6165736509664885 0.07365127922764811 18.026983140874446 7.130179270706022e-05 4.146899550751272 0.8756913214230089 LVINGNPITIFQER ddPTM_A459_Selumetinib_30min_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 175.74 0.00094891 2259200.0 1541.4 1700.0 1770.0 2237.0 1753.2 1371.2 1619.4 1232.3 1071.4 1286.0 False True 1577.3116209577072 1500.9632096914415 1529.6437219140532 1846.3499436906886 1594.6233695526 1357.4069729499877 1497.2473542135804 1199.6154009254699 1818.0875480400657 1451.0706267007774 1.086998518152047 1.0343832905667054 1.0541483603674917 1.272405291456169 1.0989288461983486 0.9354520365671326 1.0318225223935464 0.8267105534711098 1.2529283651573564 1.0 10.502902024818816 -6.651994999913922 7.767592433541232 1.0002495283914596 1.1123870438745542 0.15459771989755267 0.1161571767195258 0.4201989189111512 27.364243196901228 0.03760608630715244 0.037553377042153634 2.2284608056674552e-07 6.651994999913922 0.11213751548309459 LVINGNPITIFQERDPS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 LVINGNPITIFQERDPS(1)K;LVINGNPITIFQERDPS(1)K 162.83 3.6338e-06 142986000.0 6218.8 6483.7 6062.0 5183.6 5115.2 5199.9 6382.0 7007.1 4133.9 6549.1 True False 6363.6859403216495 5724.585389809643 5238.813696182477 4278.381568223094 4652.531063161907 5147.593727131445 5900.600601822322 6821.248945731441 7014.926371889893 7389.740778636128 0.8611514437311764 0.7746666035105753 0.7089306449460284 0.5789623339146038 0.6295932702554948 0.6965865084216797 0.798485464995073 0.9230701252000332 0.9492790859687757 1.0 12.85130804227636 -7.677359091868692 2.021138258534569 0.97052077879331 0.7018704319504807 0.7038958105251927 0.07261348871410739 0.2091282887385471 1.6901535813514341 0.05483564842461069 0.02446152703435765 2.1020396714171025e-08 7.677359091868692 -0.2686503468428293 LVINGNPITIFQERDPS(ph)KIK ddPTM_A459_Selumetinib_30min_R1 2 LVINGNPITIFQERDPSKIK 20 2 P04406;P04406-2 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 LVINGNPITIFQERDPS(1)KIK;LVINGNPITIFQERDPS(1)KIK 84.948 0.0028114 145951000.0 2379.9 2110.21 3162.3999999999996 2599.8 2430.63 2660.0 2578.7 2636.5 1559.8400000000001 1941.47 True False 2435.3470395207255 1863.1456321899864 2732.963449819774 2145.793734290144 2210.779945662581 2633.242815086761 2384.1865828767186 2566.571455441045 2646.93455379393 2190.676586019252 1.1116871632549248 0.8504886773704773 1.2475430957090423 0.9795118768258412 1.0091767811696293 1.2020226225504649 1.0883334391267219 1.1715884817598035 1.2082726271356004 1.0 11.09716079674644 -6.750467946940317 24.964114571446814 1.1419108435935916 1.0373759036722634 0.15375327110057146 0.10984989911331047 367.64624820397796 836531.9398679533 0.034778831280039314 0.034460753303474256 1.7763643678404176e-07 6.750467946940317 -0.10453493992132823 LVINGNPITIFQERDPSK ddPTM_A459_Selumetinib_30min_R1 2 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 216.0 1.0724e-13 61912000.0 5340.5 4751.8 7204.0 6832.200000000001 6277.200000000001 5558.6 5050.299999999999 5510.9 3126.7 4001.9 False True 5464.923259195947 4195.457046948113 6225.736368739459 5639.0845262778375 5709.428368329673 5502.685530804985 4669.351804980145 5364.733030073983 5305.78153486735 4515.582846807033 1.2102365175428444 0.9291064275157125 1.3787226544058813 1.2488054626802456 1.2643834831569545 1.2185991747877978 1.034052959139448 1.188048854837728 1.1749937305699234 1.0 12.140696499594865 -7.22655266976876 24.49521186500414 1.1149445924136503 1.2077536170868697 0.1638382926347336 0.11857339878637868 1077.7056254107501 756696.3815694918 0.04651940497669008 0.036032438302517476 5.935363617399118e-08 7.22655266976876 0.09280902467321939 LVLAES(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 2 LVLAESPQPK 10 0 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 LVLAES(1)PQPK;LVLAES(1)PQPK 151.26 0.00067882 56538000.0 12232.2 14008.4 15866.699999999999 16391.5 12980.4 11572.7 12314.9 12207.599999999999 6759.0 10948.2 True False 12517.186460282122 12368.290015671513 13712.089289544461 13529.032231562784 11806.325111875756 11456.28914517088 11385.977178217123 11883.81479212672 11469.529342171749 12353.508114498802 1.0132495437139202 1.001196575178136 1.1099753335209412 1.0951571089093566 0.9557062659811718 0.9273713214892462 0.9216796615735309 0.9619789522118966 0.9284430977715906 1.0 13.592633172023223 -6.339039029248611 6.505365502526617 0.9440713696631189 1.0547753853838047 0.6588983238216527 0.03718487346859444 0.15314158783439324 10.62497589827552 0.012283580593334013 0.01396457045359044 4.5810071619337435e-07 6.339039029248611 0.11070401572068578 LVLAES(ph)PQPK ddPTM_A459_Selumetinib_30min_R2 2 LVLAESPQPK 10 0 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 LVLAES(1)PQPK;LVLAES(1)PQPK 134.75 0.002048 40135000.0 338420.0 307930.0 317320.0 347500.0 337610.0 254330.0 264360.0 294330.0 213520.0 276270.0 True False 319611.9712025979 331547.2408489935 296903.976671893 300169.9005290632 295196.41352830536 289361.64892212796 276653.263819402 295186.45157104527 256229.96624726927 268293.36726433533 1.1912779449657473 1.235763836540683 1.1066392721493152 1.118812230021779 1.10027473484823 1.0785270313337085 1.0311595349535052 1.1002376040113344 0.955036529079824 1.0 18.033451863239 -4.551122249162735 0.2604615129535889 0.984881558183199 1.4450151361690649 0.7679780091095919 0.038141320546635896 4.843093819674893 0.25244445306344926 0.04955133887738302 0.731807659729325 2.811109422357213e-05 4.551122249162735 0.46013357798586585 LVLPS(ph)NTPNVR ddPTM_A459_Selumetinib_30min_R2 1 LVLPSNTPNVR 11 0 Q03188;H0Y8J2;H0Y9W1 Q03188 CENPC Centromere protein C 1 LVLPS(0.5)NT(0.5)PNVR 83.226 0.047807 0.0 22899.0 24287.0 27608.0 19534.0 22354.0 29022.0 20718.0 17131.0 17194.0 24825.0 True False 21626.36525195997 26149.73480498649 25831.73133731762 16873.435501970453 19545.690672704437 33019.51706451461 21681.428051938165 17180.848373810288 20633.28044049991 24108.237746903862 0.8970529276756187 1.0846804764211688 1.0714898205545986 0.6999033143406531 0.8107473834421856 1.36963627997883 0.8993369104601034 0.7126546765541486 0.8558601693377514 1.0 14.557238576872232 -7.5179606643658685 24.976682203906027 0.8317535854933404 0.989013525925332 0.09724989925148608 0.18103066110872237 474.08554335813983 2407701.6197624174 0.08606399680089266 0.051441470672139014 3.0341659872214405e-08 7.5179606643658685 0.15725994043199154 LVLPSNT(ph)PNVR ddPTM_A459_Selumetinib_30min_R2 1 LVLPSNTPNVR 11 0 Q03188;H0Y8J2;H0Y9W1 Q03188 CENPC Centromere protein C 1 LVLPS(0.008)NT(0.992)PNVR 120.6 0.010951 6192900.0 27734.0 26454.0 27062.0 26624.0 28529.0 24513.0 26223.0 23898.0 20010.0 24559.0 True False 26192.65530799848 28482.93673698327 25320.86038287778 22997.765271038268 24944.931967504013 27889.443243141297 27442.42145988872 23967.53922347311 24012.55912611394 23849.917858054858 1.0982283236314128 1.1942572258111026 1.0616749514014003 0.964270208724061 1.0459126994049304 1.1693727168843127 1.1506296006223167 1.0049317304201335 1.0068193638664527 1.0 14.541696676976002 -6.539642205280623 0.013450368051933718 2.577151679737183e-07 2.1572134137629173 0.1800674550554866 0.0687019559440206 3175.44380237817 14.40422256028341 1104.4298499886854 1204.5612983558626 2.886408499531908e-07 6.539642205280623 2.1572131560477494 LVNHFVEEFK ddPTM_A459_Selumetinib_30min_R1 2 LVNHFVEEFK 10 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 ; 152.54 0.00088497 30257000.0 15516.099999999999 17168.6 18735.7 19946.2 17375.8 15313.3 15744.3 16525.2 10661.099999999999 15085.5 False True 15877.594940925059 15158.492330534396 16191.4948478334 16462.970606545918 15804.16195794666 15159.262105363943 14556.694775191356 16086.898014585378 18091.1080440638 17021.870870213523 0.9327761361830781 0.8905303327767665 0.9512171118726325 0.9671657558720163 0.928462099051772 0.8905755554691143 0.8551759607496515 0.9450722624582796 1.0628154908472094 1.0 14.055101991593611 -8.121956858801736 5.097500409467711 1.0292442420536048 0.9171989960261137 0.6415992797784889 0.03375276586692855 0.1481051182713171 5.408021826386448 0.025728399100241037 0.009299416013675973 7.551672394440329e-09 8.121956858801736 -0.11204524602749111 LVNHFVEEFKR ddPTM_A459_Selumetinib_30min_R1 2 LVNHFVEEFKR 11 1 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 ; 107.45 0.0071095 24910000.0 13695.9 16359.6 17663.8 18955.2 17251.0 15206.5 15224.6 16126.599999999999 9193.2 13888.9 False True 14014.987822417705 14444.210426628302 15265.152980308165 15645.030153171994 15690.650095911422 15053.536416397294 14076.196164604211 15698.870181420658 15600.188955237954 15671.675604342481 0.8942877696201341 0.921676200509532 0.9740600409108984 0.998299770117555 1.0012107506592136 0.960556917872017 0.8981934363613182 1.0017352692695247 0.995438480803883 1.0 13.935871819528302 -5.13945338526402 2.8964403033692334 0.9770374075995825 0.8974965589071604 0.4791772996436042 0.03007003175279911 0.26349426003313664 4.081351470350778 0.008619144912803297 0.0322971043169163 7.253483287380321e-06 5.13945338526402 -0.07954084869242206 LVNTT(ph)ITPEPEPKPQPNSR ddPTM_A459_Selumetinib_30min_R2 1 LVNTTITPEPEPKPQPNSR 19 1 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 LVNT(0.185)T(0.56)IT(0.255)PEPEPKPQPNSR 108.97 0.00099198 6499300.0 24069.0 25662.0 34490.0 34044.0 31228.0 19486.0 22512.0 22455.0 19280.0 25857.0 True False 22731.341335841043 27630.192883664648 32270.950949872662 29407.148470824315 27304.859458137875 22170.019623703818 23558.85260668175 22520.340332374642 23136.538728209758 25110.441225445848 0.9052545565310925 1.100346769520935 1.2851606493147025 1.1711123753980224 1.0873906680089833 0.882900440683522 0.9382094243253765 0.8968516375392677 0.9213911663473352 1.0 14.61599975854397 -6.6712401339414065 5.074028031448844 0.922401997632908 1.1263847550702135 0.490057862611993 0.09257779565914045 0.17946064391477123 7.709240681311561 0.032980596529192024 0.03268398028790751 2.1318658171184342e-07 6.6712401339414065 0.20398275743730554 LVNTTIT(ph)PEPEPKPQPNSR ddPTM_A459_Selumetinib_30min_R1 1 LVNTTITPEPEPKPQPNSR 19 1 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 LVNTT(0.002)IT(0.997)PEPEPKPQPNSR 143.58 0.0001018 15291000.0 2270.3 2020.8 2504.4 3428.0 2382.2 2040.8 2135.0 1966.2 1427.7 1606.0 True False 2323.193572765201 1784.203796555567 2164.316235684493 2829.3641515295867 2166.730430611569 2020.2714048981418 1973.955231101638 1914.0499888822992 2422.702624917681 1812.1457437647339 1.2820125427322226 0.984580739542992 1.1943389449394533 1.5613336627392789 1.1956711749410316 1.114850398677662 1.0892916521166476 1.056234022825261 1.3369248214464886 1.0 10.823483275008183 -6.528940713220081 18.75572688519488 1.1248848738388157 1.2501693628967352 0.1472679408234041 0.1543143676669308 16.800857605082108 51969.2806249448 0.0532644593422381 0.0536330263926104 2.9584163008440733e-07 6.528940713220081 0.12528448905791945 LVNTTIT(ph)PEPEPKPQPNSR ddPTM_A459_Selumetinib_30min_R2 1 LVNTTITPEPEPKPQPNSR 19 1 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 LVNT(0.002)T(0.007)IT(0.992)PEPEPKPQPNSR 176.7 1.1608e-12 4717500.0 23045.0 23652.0 22801.0 24972.0 23491.0 19768.0 21017.0 21665.0 18024.0 28754.0 True False 21764.251156444276 25466.0323468333 21334.008483851736 21570.77052089722 20539.85056779547 22490.862563962684 21994.33214439545 21728.04156316617 21629.30363263758 27923.7973081359 0.7794158837452607 0.911983139893853 0.7640081414584627 0.7724870039295243 0.7355679580803633 0.8054371085629435 0.7876554861679633 0.7781191549057502 0.7745831769927526 1.0 14.769207524001864 -11.467091595063474 5.516945912454216 1.1030484785376347 0.7906773280681206 0.6699639470645637 0.044232124342846235 0.031938380334752145 0.00032295961063073407 0.024398140884125716 0.010726737024058016 3.4112095977274313e-12 11.467091595063474 -0.312371150469514 LVPLLDTGDIIIDGGNSEYRDTTR ddPTM_A459_Selumetinib_30min_R1 1 LVPLLDTGDIIIDGGNSEYRDTTR 24 1 P52209-2;P52209;K7EM49;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 130.02 3.3482e-07 8412200.0 1565.3 1286.6 2430.2 2557.1 1955.9 1599.5 1345.4 1270.0 1015.4 899.84 False True 1601.768444456402 1135.9642738758866 2100.192188133068 2110.5504877118733 1778.989190342192 1583.4104822298018 1243.9153948122455 1236.3154744586116 1723.0596381182415 1015.3432291838475 1.5775635257290626 1.1187982952218007 2.0684554028308666 2.0786571742920614 1.7521062230081328 1.559482977497745 1.2251181266182558 1.2176330514878067 1.6970218430503252 1.0 9.98775178678868 -7.051013626585963 3.6612324859559555 1.3054254800771468 1.7225676388130506 0.3174956648597248 0.2992203885133165 0.3345184627286829 9.074487473051235 0.12659722206293164 0.099845683545613 8.891732183890687e-08 7.051013626585963 0.4171421587359039 LVPS(ph)QEETK ddPTM_A459_Selumetinib_30min_R2 4 LVPSQEETK 9 0 P49321-4;P49321;P49321-3 P49321-4 NASP Nuclear autoantigenic sperm protein 1 LVPS(1)QEETK;LVPS(1)QEETK;LVPS(0.997)QEET(0.003)K;LVPS(0.998)QEET(0.002)K 119.27 0.006948899999999999 47368500.0 341216.0 246498.0 279044.0 289912.0 299615.0 264901.0 320619.0 337316.0 294983.0 244396.0 True False 322252.5807158731 265403.60398400686 261090.61284013497 250425.48547390476 261974.6851079154 301388.70821814466 335528.41879449587 338297.5337143301 353987.8425136675 237339.65246293283 1.3577696662642655 1.1182438384393312 1.1000716067910798 1.0551354688320176 1.1037965312131315 1.2698624317115104 1.4137056969311015 1.4253730053268898 1.49148209681883 1.0 17.85659362693923 -6.959576661072157 3.9376917666849205 1.366497275214682 1.1385851978851589 0.2532288905262259 0.14636099903698988 0.24938193569701744 8.314256730174325 0.05322482118359454 0.04513879871786164 1.09754753557309e-07 6.959576661072157 -0.22791207732952312 LVPSDKFS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 LVPSDKFSPR 10 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;H0Y4T4 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 LVPS(0.002)DKFS(0.998)PR 70.72800000000002 0.040243 17841000.0 91023.0 88942.0 84964.0 108120.0 91436.0 73841.0 92335.0 81236.0 59538.0 75197.0 True False 85964.30605393917 95763.56540639471 79497.50874180876 93393.86948259658 79948.99223178861 84011.9274881408 96628.76045833148 81472.38331065617 71447.26363071325 73025.86722473019 1.1771761065074677 1.3113649867613542 1.0886212209868418 1.2789148973087274 1.0948037355825322 1.150440668230643 1.3232127755630156 1.1156647145309844 0.9783829531368804 1.0 16.156119965549998 -8.078645753134802 4.17013858386886 0.9949402177873219 1.2011787911416778 0.5406282782669057 0.07825521814256518 0.17440088870864173 5.502395497868363 0.055177882749878594 0.01972348642681689 8.343614820647422e-09 8.078645753134802 0.20623857335435591 LVPVS(ph)PLPPK ddPTM_A459_Selumetinib_30min_R1 1 LVPVSPLPPK 10 0 O95396 O95396 MOCS3 Adenylyltransferase and sulfurtransferase MOCS3;Molybdopterin-synthase adenylyltransferase;Molybdopterin-synthase sulfurtransferase 1 LVPVS(1)PLPPK 105.2 0.012654 32815000.0 6824.3 8042.5 8268.8 9066.7 8535.5 7170.0 7686.3 7408.9 3949.5 5925.2 True False 6983.292912223745 7100.880361143187 7145.942377267186 7483.371048037716 7763.465532064917 7097.876309839125 7106.516202724371 7212.391904501106 6702.013039933022 6685.757136335498 1.0445029291104833 1.062090682676999 1.068830684625185 1.1193004614791309 1.1611946670740296 1.061641361643823 1.0629336450320859 1.078769652774773 1.0024314229886062 1.0 12.706875233908736 -8.254533633506915 3.9841344805419077 0.9981150238844838 1.0843792387949933 0.5025487967201839 0.032302936659399976 0.19181739439922887 6.898151411490201 0.03079893471505005 0.009219514018668636 5.565015348780362e-09 8.254533633506915 0.0862642149105095 LVPVS(ph)PLPPK ddPTM_A459_Selumetinib_30min_R2 2 LVPVSPLPPK 10 0 O95396 O95396 MOCS3 Adenylyltransferase and sulfurtransferase MOCS3;Molybdopterin-synthase adenylyltransferase;Molybdopterin-synthase sulfurtransferase 1 LVPVS(1)PLPPK;LVPVS(1)PLPPK 105.13 0.012697 39813000.0 185278.0 170576.0 186350.0 198450.0 191296.0 129231.0 154421.0 152581.0 134036.0 161473.0 True False 174980.99048659913 183658.63071171346 174360.44388253932 171420.76765465524 167263.6862720619 147031.3972077833 161601.8824794064 153024.98544885564 160846.94527875114 156810.85493276143 1.115872944903137 1.171211207224551 1.111915651230286 1.0931690138935748 1.0666588505227046 0.9376353267816093 1.0305529075056654 0.9758570955720564 1.0257385902762939 1.0 17.258665905163035 -6.2984557464821584 1.7552488970612508 0.9951290689195278 1.1355770973094113 0.7876307800979623 0.03142949906309285 0.15087814574369018 0.9182533408318972 0.010825975418720551 0.013984729600568508 5.029725148763812e-07 6.2984557464821584 0.14044802838988346 LVQAFQFTDK ddPTM_A459_Selumetinib_30min_R1 2 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 ; 188.04 0.0025743000000000003 39199000.0 3757.0 4265.0 4762.6 5327.1 4409.1 4291.7 3860.1 4198.8 3414.3 3677.3 False True 3844.5307901505794 3765.6518172552924 4115.865079089189 4396.82198705171 4010.2976834898313 4248.529394551821 3568.929549215661 4087.434184375448 5793.817729394437 4149.317274935277 0.9265453893762675 0.9075352805634828 0.9919379036044887 1.0596495027294082 0.9664957914196585 1.023910468407864 0.8601245247680731 0.9850859583735267 1.3963303708764503 1.0 12.018658260858206 -8.10040629155434 10.191000898279022 1.1974355339922969 0.9644297783176414 0.4481883846032355 0.1036640439151712 0.3904684250543022 37.40588684453222 0.06540608468057137 0.024681604303781215 7.935854715673502e-09 8.10040629155434 -0.23300575567465542 LVQAFQFTDK ddPTM_A459_Selumetinib_30min_R2 3 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 ;; 174.41 0.0011683 15487100.0 64976.0 57418.0 65446.0 68681.0 59983.0 53591.0 57121.0 52098.0 43606.0 57137.0 False True 61364.89403953666 61821.77597203091 61235.275612217076 59326.52931866659 52447.399285176274 60972.67379933857 59777.23968311423 52249.59655471181 52328.41845343957 55487.30635024555 1.105926707852617 1.1141606979765983 1.1035907064165151 1.0691910136020515 0.9452143694653179 1.0988580597960267 1.077313778863041 0.9416495409761514 0.9430700802654479 1.0 15.759870148127474 -6.18096112726789 0.4180031134325265 0.9682742432994385 1.1478143412463218 0.4667913901225822 0.05124557216359096 1.8113045862088188 0.5465500744200193 0.052270966380009415 0.1447949444118144 6.592328990726318e-07 6.18096112726789 0.1795400979468833 LVQAFQYTDK ddPTM_A459_Selumetinib_30min_R1 1 LVQAFQYTDK 10 0 Q13162;H7C3T4 Q13162 PRDX4 Peroxiredoxin-4 0 204.07 0.0031494 49205000.0 2878.1 3435.8 3459.2 3643.4 3462.7 2974.9 3260.3 2943.2 1694.7 2072.6 False True 2945.154130192278 3033.534938739916 2989.459640025476 3007.1485850883605 3149.4993963893385 2944.9752069930837 3014.37294611741 2865.1367751390408 2875.7821240092394 2338.638398833617 1.259345665264522 1.2971372317553986 1.2782906675595733 1.285854447009918 1.346723545615318 1.2592691578406794 1.2889435782893206 1.2251303051245597 1.2296822482019965 1.0 11.191453093535566 -9.161392369954312 0.6945820427411029 0.9937763330035744 1.2919255145090929 0.9163473859523595 0.02567401164299191 0.5630425586508259 0.4035504966654691 0.03287529775352244 0.009411359578302834 6.896164778115661e-10 9.161392369954312 0.2981491815055185 LVQAFQYTDK ddPTM_A459_Selumetinib_30min_R2 1 LVQAFQYTDK 10 0 Q13162;H7C3T4 Q13162 PRDX4 Peroxiredoxin-4 0 120.31 0.044101 0.0 23345.0 26014.0 25022.0 31467.0 31496.0 20373.0 21794.0 20856.0 19467.0 25910.0 False True 22047.57835743943 28009.19015180627 23412.11176189369 27181.140316397257 27539.190902187467 23179.19582231949 22807.464183991728 20916.687507103336 23360.943953426297 25161.910977735315 0.8762282950984278 1.113158304096632 0.930458413218696 1.0802494429158689 1.0944793074959889 0.9212017260068106 0.9064281406993715 0.8312837417480574 0.9284248709924053 1.0 14.61895387463659 -6.891729503667986 7.38546007195894 0.9041462335930468 1.022377276258104 0.2886009013185401 0.07856344510090664 0.2557911270782421 15.843254376221337 0.02663205483673276 0.023491728964461472 1.2831295192692888e-07 6.891729503667986 0.11823104266505724 LVQS(ph)PNSYFMDVK ddPTM_A459_Selumetinib_30min_R1 1 LVQSPNSYFMDVK 13 0 H0YMV8;Q71UM5;C9JLI6;P42677 H0YMV8;P42677 RPS27L;RPS27 40S ribosomal protein S27;40S ribosomal protein S27-like 1 LVQS(0.999)PNS(0.001)YFMDVK 135.72 0.0011324000000000002 18506000.0 4259.0 5539.1 4936.7 5052.8 4373.0 3989.4 4703.2 4030.2 2133.9 4110.8 True False 4358.226413428617 4890.579596942271 4266.323255352037 4170.423332803 3977.462922115856 3949.2702580853825 4348.433837431958 3923.306004065426 3621.072446110413 4638.461222582858 0.9395845312255955 1.054353882087436 0.9197712453821915 0.8990963021311543 0.857496210758676 0.8514181899070162 0.9374733621273215 0.8458205891566755 0.7806624378966076 1.0 12.179430565286353 -5.526277440084699 3.1818975323256415 0.8754684581863265 0.9971601443432584 0.3478300511804222 0.061395325786178886 0.23984498752005115 4.988555624968695 0.016434813345999964 0.034577400308726906 2.976614273197432e-06 5.526277440084699 0.12169168615693193 LVQS(ph)PNSYFMDVK ddPTM_A459_Selumetinib_30min_R2 2 LVQSPNSYFMDVK 13 0 H0YMV8;Q71UM5;C9JLI6;P42677 H0YMV8;P42677 RPS27L;RPS27 40S ribosomal protein S27;40S ribosomal protein S27-like 1 LVQS(0.824)PNS(0.176)YFMDVK;LVQS(0.982)PNS(0.018)YFMDVK 170.35 0.00023012 16006800.0 65736.0 65689.0 67883.0 75539.0 76742.0 66333.0 63574.0 62638.0 55647.0 78305.0 True False 62082.65628205779 70727.13507657418 63515.481685421975 65250.45788795675 67100.98387781525 75469.76863897896 66530.31696949116 62820.2662097209 66777.95490708966 76044.13118917639 0.816402992725548 0.9300801254553751 0.8352450174940304 0.8580604034469402 0.8823952989992994 0.992446983860351 0.8748908815064567 0.8261027541157879 0.878147384457124 1.0 16.214549289813682 -6.526551645822208 24.99888101425017 0.9050333216530272 0.8640716452998263 0.16056632363729328 0.05658427567390232 271.67590448919185 1849083.2305183075 0.018962008060821635 0.01904837217134409 2.974735485573406e-07 6.526551645822208 -0.040961676353200915 LVRLS(ph)SDSFAR ddPTM_A459_Selumetinib_30min_R2 1 LVRLSSDSFAR 11 1 A0A087WSV0;Q9HB09-3;Q9HB09 A0A087WSV0 BCL2L12 Bcl-2-like protein 12 1 LVRLS(0.78)S(0.215)DS(0.005)FAR 67.01899999999999 0.041796 8936300.0 19119.0 14205.0 17761.0 18780.0 11803.0 9620.0 14726.0 11237.0 9472.5 13493.0 True False 18056.442519421053 15294.477823725978 16618.276596714666 16222.131602693014 10320.201619841208 10945.067678334728 15410.788179015426 11269.69780961451 11367.264683763842 13103.42203097578 1.3779944259397736 1.1672124875143806 1.2682394383261075 1.2380072598092906 0.7875959116210108 0.8352831537029931 1.1760888218806627 0.8600576080792907 0.8675035160198797 1.0 13.677656008289802 -6.23667353566619 17.41544187477589 0.9225516537266449 1.2564193869164186 0.6893387542147358 0.11236595377146431 10.707262762617011 7528.48083003315 0.03382871474787473 0.04356620887907132 5.798644236282131e-07 6.23667353566619 0.3338677331897737 LVS(ph)PAPGPGPQPHLVITEQPK ddPTM_A459_Selumetinib_30min_R2 1 LVSPAPGPGPQPHLVITEQPK 21 0 Q01201;D6R992 Q01201 RELB Transcription factor RelB 1 LVS(1)PAPGPGPQPHLVITEQPK 86.189 0.00069287 4271300.0 17521.0 17353.0 17771.0 20165.0 16485.0 17654.0 16334.0 12024.0 11254.0 18960.0 True False 16547.252962120197 18683.919301310605 16627.63320760183 17418.492213434733 14414.00692223014 20085.678252944002 17093.563365206985 12058.98784931964 13505.114463032802 18412.57553600392 0.8986930117279751 1.0147368718067769 0.9030585197105199 0.94601063166718 0.7828349105232463 1.0908673918903145 0.9283635161079047 0.654932159042037 0.7334723182329883 1.0 14.168403823354755 -7.659486619192339 9.002574711429682 0.7711169500803242 0.9404105708170687 0.2461227613805741 0.11113185997974204 0.30752838340353617 24.44708661651529 0.05035818556390982 0.028980264356843963 2.1903493126729846e-08 7.659486619192339 0.16929362073674448 LVS(ph)PEPPPK ddPTM_A459_Selumetinib_30min_R2 3 LVSPEPPPK 9 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 LVS(1)PEPPPK;LVS(1)PEPPPK;LVS(1)PEPPPK 99.973 0.018330000000000003 27674400.0 383959.0 290992.0 324736.0 323954.0 327584.0 264878.0 291051.0 308380.0 269504.0 274819.0 True False 362620.09588965884 313310.1507132468 303842.83930582297 279830.9063481795 286429.9692818831 301362.54017691786 304585.4482066157 309277.33474494255 323412.33057092526 266884.2614044869 1.358716673592362 1.173955140945525 1.1384816688209354 1.048510335062699 1.0732366448832025 1.129188130431476 1.1412641817232876 1.1588444111217377 1.211807428691964 1.0 18.025854704370836 -4.6937284140005415 2.0433729511950536 1.1162072329820436 1.4676126372828098 0.6305303161261746 0.05667412208220737 0.6552302499888609 2.4904260292268643 0.015493929779388484 0.46815419208442605 2.0242846691122924e-05 4.6937284140005415 0.35140540430076617 LVS(ph)PEQPPK ddPTM_A459_Selumetinib_30min_R1 1 LVSPEQPPK 9 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 LVS(1)PEQPPK 115.91 0.008015399999999999 6740500.0 4876.6 5085.5 4767.8 5537.0 4433.1 4623.5 4497.7 3877.1 2804.7 3668.8 True False 4990.215291788212 4490.08729581519 4120.358947650748 4570.066892362693 4032.126887727375 4576.99178780212 4158.434867880954 3774.2667134043136 4759.371052816852 4139.726217138268 1.205445729992713 1.0846338768072257 0.9953216061952742 1.1039538975893708 0.9740081049405063 1.1056266882707346 1.0045192966301086 0.91171891942492 1.1496825642993693 1.0 12.0153196421843 -4.821962497431999 2.77902532784023 1.0297830832417159 1.2298230346463235 0.3810534319833885 0.06751129530034261 0.39157014431530535 4.438535998242058 0.016505334173039475 0.1742805520518079 1.5067371716242139e-05 4.821962497431999 0.20003995140460762 LVS(ph)PEQPPK ddPTM_A459_Selumetinib_30min_R2 1 LVSPEQPPK 9 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 LVS(1)PEQPPK 80.916 0.045196 1928500.0 38938.0 40962.0 35379.0 39672.0 39145.0 27567.0 31171.0 30686.0 27112.0 33203.0 True False 36773.981841164095 44103.65368641067 33102.753657742665 34268.6051619828 34227.25513925985 31364.10402168956 32620.513264164736 30775.291179659216 32535.15757257379 32244.343118245688 1.1404785548369656 1.3677950741522256 1.0266220507686894 1.062778827167103 1.0614964309783725 0.9727009760028872 1.0116662369129235 0.9544400103547094 1.0090190844720153 1.0 14.976758458810917 -5.3242799015485005 8.543491216933008 1.0124525785073746 1.253707070030134 0.7217536639122772 0.06005822669306628 0.1581323925279215 20.2884346892179 0.015177101142192584 0.031760892891095766 4.739364361337013e-06 5.3242799015485005 0.24125449152275946 LVS(ph)PGSANETSSILVESVTR ddPTM_A459_Selumetinib_30min_R1 3 LVSPGSANETSSILVESVTR 20 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 LVS(1)PGSANETSSILVESVTR;LVS(0.992)PGS(0.008)ANETSSILVESVTR;LVS(1)PGSANETSSILVESVTR 265.42 2.4401999999999997e-48 320433000.0 12608.100000000002 14347.400000000001 12007.0 13483.7 14869.500000000002 11935.8 13374.8 12399.6 6659.9 11028.4 True False 12901.84419890805 12667.599738074692 10376.515349729956 11129.024915396583 13524.556350423447 11815.73668883931 12365.928067886749 12070.72232842283 11301.363880149374 12444.002565712955 1.0367921519444707 1.017968267941202 0.8338567349962173 0.894328400900564 1.0868332981293132 0.949512556465979 0.9937259336444267 0.9700032015166384 0.9081775594685346 1.0 13.603162976990262 -5.025990980432198 24.934021919596063 0.9551847140981476 1.0320862847087802 0.1714808092150717 0.06460087709579317 1098.581523928629 1053910.308828685 0.01709972963765777 0.04562102447064728 9.419091581927464e-06 5.025990980432198 0.07690157061063252 LVS(ph)PGSANETSSILVESVTR ddPTM_A459_Selumetinib_30min_R2 6 LVSPGSANETSSILVESVTR 20 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 LVS(0.999)PGS(0.001)ANETSSILVESVTR;LVS(1)PGSANETSSILVESVTR;LVS(0.939)PGS(0.061)ANETSSILVESVTR;LVS(0.556)PGS(0.442)ANET(0.001)S(0.001)SILVESVTR;LVS(0.587)PGS(0.413)ANETSSILVESVTR;LVS(0.993)PGS(0.007)ANETSSILVESVTR 216.61 2.5052e-19 122152000.0 144951.40000000002 136374.4 159568.0 166900.5 186188.0 144198.1 127497.4 137803.0 137443.3 148886.7 True False 136895.58147442882 146833.87796719017 149301.56860450227 144168.36398057817 162797.39889816125 164060.07937497704 133426.28173130532 138203.98391548535 164935.80048666795 144587.9541168962 0.9467979702081664 1.015533270831664 1.0326003263300567 0.9970980284015998 1.1259402617077154 1.134673219335672 0.9228035803275361 0.9558471503355698 1.1407298864836344 1.0 17.141587838207755 -4.323959671613135 1.3054050507583348 1.0392776788749494 0.7777222930561251 0.13217570878939267 0.0712239027984292 8.977139326787604 5.989313356272727 0.021777297563141056 4.191807461100869 4.7428602519872456e-05 4.323959671613135 -0.2615553858188243 LVS(ph)PSDQR ddPTM_A459_Selumetinib_30min_R2 2 LVSPSDQR 8 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 LVS(0.855)PS(0.145)DQR;LVS(0.975)PS(0.025)DQR 85.807 0.037516 3139800.0 92752.0 99292.0 116464.0 113518.0 135300.0 96781.0 103550.0 108001.0 97438.0 117125.0 True False 87597.21515567451 106907.37712589948 108970.83303641554 98056.65257052725 118302.40440265335 110111.70425955433 108365.28018043243 108315.26502947198 116928.32264519208 113743.29692270361 0.7701307903462904 0.9399004602315194 0.9580418010080076 0.8620873073264571 1.0400824277411966 0.9680720291973144 0.9527179456919918 0.9522782261453143 1.0280018762305871 1.0 16.795422001890408 -3.989713831257775 1.1347322321289077 0.9714896997864091 1.1022485105303312e-33 0.6209255582641355 0.04656680555769537 5.648437397184026 1.6274069629717696 0.01401532878654669 10.086616722975094 0.00010239674907612247 3.989713831257775 -0.9714896997864091 LVSFHDDS(ph)DEDLLHI ddPTM_A459_Selumetinib_30min_R1 5 LVSFHDDSDEDLLHI 15 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 LVSFHDDS(1)DEDLLHI;LVSFHDDS(1)DEDLLHI;LVSFHDDS(1)DEDLLHI;LVSFHDDS(1)DEDLLHI;LVSFHDDS(1)DEDLLHI 173.03 2.3212e-05 17887400.0 8246.28 6745.63 9488.150000000001 8208.789999999999 13078.57 8323.9 11271.89 9148.21 2729.71 5867.99 True False 8438.40227953232 5955.848503641694 8199.711344677304 6775.278924572503 11895.615652709077 8240.169123496493 10421.642262249303 8905.569753225995 4632.118499869747 6621.203675562907 1.2744513978139969 0.8995114476878485 1.238401920022525 1.0232699757565602 1.7965941293442784 1.2445122559677109 1.5739800152520302 1.345007673769963 0.6995885834120552 1.0 12.692877794581658 -8.253210253578585 24.894977145727307 0.849794285550402 1.2987818847207993 0.3453344889964516 0.24765258348250108 598.064679902113 1809296.3582435471 0.1794106646248993 0.0652547579945289 5.58199889809446e-09 8.253210253578585 0.4489875991703972 LVSFHDDS(ph)DEDLLHI ddPTM_A459_Selumetinib_30min_R2 2 LVSFHDDSDEDLLHI 15 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 LVSFHDDS(1)DEDLLHI;LVSFHDDS(1)DEDLLHI 102.64 0.0040805 2253800.0 23101.7 12420.0 21289.5 31636.0 31735.0 19950.0 26087.0 21766.6 23077.0 23264.5 True False 21817.79999743235 13372.574063405616 19919.75674825498 27327.122224856015 27748.165585500366 22697.931411931175 27300.097190409826 21829.937202345376 27693.044825253954 22592.79343656978 0.9656973166548326 0.5918955573576894 0.8816863131237195 1.2095503949778528 1.2281865747767982 1.004653606720062 1.2083542155624092 0.9662345324244143 1.2257468251105532 1.0 14.463575040184429 -5.605180023609267 5.032081757216493 1.1209709410166704 0.7688433002405015 0.5589510319290055 0.1269288452169598 0.12857795692931742 5.652389324115687 0.032676372375204814 0.05824630784934143 2.482104011062277e-06 5.605180023609267 -0.35212764077616887 LVSPETEAS(ph)EESLQFNLEKPATGER ddPTM_A459_Selumetinib_30min_R1 1 LVSPETEASEESLQFNLEKPATGER 25 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LVS(0.001)PET(0.049)EAS(0.941)EES(0.01)LQFNLEKPATGER 133.46 2.82e-08 8930700.0 657.97 780.25 718.15 868.87 814.92 626.07 703.96 483.4 462.65 539.5 True False 673.2994208132494 688.8979672716163 620.62917451558 717.1381652098923 741.2106298858112 619.7723042260778 650.8597304385524 470.57866169550584 785.0832593809378 608.7500801750149 1.106035863879766 1.131659756124482 1.0195139101043729 1.1780502189071023 1.2175943035156793 1.0181063204918086 1.0691739543614205 0.7730243937877019 1.2896643219418178 1.0 9.249706246978885 -6.805379737078052 23.488185446888785 1.018256220641167 1.127099199462253 0.13330440342862648 0.12631364414698695 140.68988592468128 75203.68714827947 0.042657871498222893 0.03762109008964017 1.56538173785279e-07 6.805379737078052 0.10884297882108607 LVSPETEAS(ph)EESLQFNLEKPATGER ddPTM_A459_Selumetinib_30min_R2 1 LVSPETEASEESLQFNLEKPATGER 25 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 LVS(0.001)PET(0.033)EAS(0.911)EES(0.055)LQFNLEKPATGER 69.27199999999999 0.00076388 5137400.0 7642.8 6846.6 7126.4 6690.9 8210.4 6322.9 5927.7 4675.6 7254.9 7793.2 True False 7218.043772552498 7371.712204711181 6667.895182637652 5779.587877553704 7178.936150092714 7193.822081428552 6203.34979551472 4689.205221912754 8706.082718842785 7568.1900668346925 0.9537344740036848 0.9740389894560766 0.8810422470568874 0.763668436774732 0.948567106097432 0.9505340137998523 0.8196609414844148 0.619594008673458 1.1503520183768328 1.0 12.885732605505964 -5.2789259425188035 9.352747316282882 0.8750420270506135 0.9639189404784159 0.03232781032179355 0.13545522194530496 0.8389552004149938 433.2873857287727 0.034352808683260044 0.07456624043328844 5.261069724243888e-06 5.2789259425188035 0.08887691342780235 LVSPGS(ph)ANETSSILVESVTR ddPTM_A459_Selumetinib_30min_R1 3 LVSPGSANETSSILVESVTR 20 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 LVS(0.403)PGS(0.597)ANETSSILVESVTR;LVS(0.228)PGS(0.772)ANETSSILVESVTR;LVSPGS(1)ANETSSILVESVTR 220.86 1.3754e-19 20540300.0 4263.7 4516.8 4320.4 5150.700000000001 5798.900000000001 4015.7000000000003 4597.8 4439.2 2353.63 3534.3900000000003 True False 4363.0359142840125 3987.9709561966483 3733.7134102584587 4251.226935613608 5274.390518878951 3975.305703963874 4250.984244289985 4321.457995446194 3993.9382076661745 3988.063384374 1.0940237137100746 0.9999768237942972 0.9362221836513096 1.065987805577698 1.3225443054754416 0.9968010336896567 1.0659269511478076 1.083598122431679 1.0014731017854914 1.0 11.961472624086097 -4.437432486297749 19.882215276084363 1.0583138573459725 2.8812076263048323 0.012409076731874524 0.09964871570427306 1162.8339303445446 285479.712510942 0.02507493923885142 5239.892343768079 3.65230900192903e-05 4.437432486297749 1.8228937689588598 LVSPGS(ph)ANETSSILVESVTR ddPTM_A459_Selumetinib_30min_R2 4 LVSPGSANETSSILVESVTR 20 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 LVS(0.236)PGS(0.764)ANETSSILVESVTR;LVSPGS(0.999)ANETSSILVESVTR;LVS(0.003)PGS(0.882)ANET(0.029)S(0.043)S(0.043)ILVESVTR;LVSPGS(0.999)ANETSSILVESVTR 223.54 6.6546e-20 8642100.0 39942.0 35825.4 47248.0 45767.1 46321.0 36203.8 36434.4 37219.3 32893.0 39281.5 True False 37722.183540494545 38573.092983182876 44208.11511973281 39533.542027348834 40501.74186500593 41190.544824625256 38128.67179339397 37327.602001013176 39472.51910720973 38147.34102940599 0.9888548591477527 1.0111607242415324 1.158878022079045 1.0363380765352503 1.0617186092678137 1.0797749912077335 0.999510601905448 0.9785112407241985 1.034738412744999 1.0 15.219294880452523 -7.274646944530554 23.948063348062284 1.0013993237244359 1.058103239401493 0.2529404571871824 0.04444304021128512 652.6342876986702 1183355.4043174968 0.019124012062716998 0.012987373927739524 5.3131619704045696e-08 7.274646944530554 0.05670391567705724 LVSVQEDAGKS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 LVSVQEDAGKSPAR 14 1 Q9Y2I7;E9PDH4;Q9Y2I7-2;Q9Y2I7-3;Q9Y2I7-4 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 LVSVQEDAGKS(1)PAR 67.153 0.036895 4342000.0 23884.0 18365.0 17668.0 20258.0 23138.0 15021.0 15630.0 18487.0 11297.0 18059.0 True False 22556.62289522738 19773.536447217713 16531.260115463912 17498.82545300079 20231.197583655514 17090.006402938252 16356.825970257445 18540.7941093124 13556.715664553198 17537.58974708306 1.2861871682783041 1.1274945264645928 0.9426187038166676 0.9977896452909832 1.1535905375492357 0.9744786284432698 0.9326724028869471 1.0572030921407656 0.7730090542691602 1.0 14.09816286627932 -1.522888037206599 0.7795309903281146 0.9761082378640601 70.34814666692142 0.5158956647932154 0.0930942881030598 368.8323630841975 1.4022042324249389 0.033913841495490406 45089.314920392375 0.02999935814333959 1.522888037206599 69.37203842905737 LVTDQNISENWR ddPTM_A459_Selumetinib_30min_R2 1 LVTDQNISENWR 12 0 F2Z2Q9;G5E9R5;P24666-4;P24666 F2Z2Q9 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 211.37 6.900399999999999e-05 3071900.0 7574.2 5917.9 7566.3 9964.1 9936.8 6391.7 6399.2 7838.9 6817.3 6877.2 False True 7153.25628592494 6371.783900952343 7079.492495564561 8606.972390968767 8688.450347880895 7272.0986569243405 6696.77547977424 7861.709901200247 8180.950491277199 6678.637366888512 1.071065232765819 0.9540544801163343 1.0600204961963375 1.2887318053291223 1.3009315928660352 1.0888596366944705 1.002715840356246 1.1771428016405259 1.2249430597679831 1.0 12.705338066318733 -5.53565365219655 24.46313780766767 1.1603221944210425 1.01117923512165 0.2522633785584413 0.1015963860288148 223.1281665777934 427274.4439267106 0.029114892337210794 0.05047069911114319 2.91303932710881e-06 5.53565365219655 -0.14914295929939247 LVTSGAESGNLNTS(ph)PSSNQTR ddPTM_A459_Selumetinib_30min_R1 3 LVTSGAESGNLNTSPSSNQTR 21 0 Q8NHV4-2;Q8NHV4;Q8NHV4-3 Q8NHV4-2 NEDD1 Protein NEDD1 1 LVTSGAESGNLNT(0.063)S(0.849)PS(0.085)S(0.003)NQTR;LVTSGAESGNLNT(0.022)S(0.88)PS(0.075)S(0.023)NQTR;LVTSGAESGNLNT(0.229)S(0.49)PS(0.14)S(0.14)NQTR 340.33 5.891599999999998e-175 55800900.0 5898.790000000001 6841.4 6424.2 7497.7 6990.099999999999 5546.7 5557.42 5638.53 3132.67 5238.759999999999 True False 6036.220329952713 6040.405707519425 5551.828925604663 6188.367444260025 6357.846689202385 5490.905234000647 5138.21933509549 5488.977867873317 5315.912188835801 5911.205875843672 1.021148722736915 1.0218567639817338 0.9392041221728353 1.0468874835757256 1.0755583247715876 0.9288976478453242 0.8692336966460573 0.9285715948930483 0.8992940358513721 1.0 12.529236752397972 -6.876752826147782 7.400516146935713 0.9157790860629652 1.0176362203701403 0.5285073091274843 0.044855272216065334 0.17751289537995832 10.809913649875588 0.015905168788766504 0.014034205162669828 1.3281501444799725e-07 6.876752826147782 0.10185713430717513 LVTSGAESGNLNTS(ph)PSSNQTR ddPTM_A459_Selumetinib_30min_R2 1 LVTSGAESGNLNTSPSSNQTR 21 0 Q8NHV4-2;Q8NHV4;Q8NHV4-3 Q8NHV4-2 NEDD1 Protein NEDD1 1 LVTSGAESGNLNT(0.249)S(0.352)PS(0.047)S(0.352)NQTR 180.03 2.8769e-14 45723000.0 62816.0 49838.0 63482.0 76911.0 71623.0 48448.0 67821.0 63417.0 57692.0 72943.0 True False 59324.938192371585 53660.41434557238 59397.63723397554 66435.58912112463 62625.07842225599 55121.272232844225 70974.8108847619 63601.532970750464 69232.01204916372 70836.94606132545 0.8374858247137361 0.757520154794888 0.8385121117806718 0.9378663651537089 0.8840736635941331 0.778142979020076 1.001946227655228 0.8978582012229734 0.9773432636300795 1.0 16.112214395180303 -6.174953628234984 0.22115081098367287 1.024123126319128 0.7049982188232226 0.5008368147700938 0.059157256058260575 5.429675051537704 0.44270723740478973 0.13429861709603144 0.49843583886484927 6.684152837568699e-07 6.174953628234984 -0.3191249074959054 LVTSGAESGNLNTSPS(ph)SNQTR ddPTM_A459_Selumetinib_30min_R2 1 LVTSGAESGNLNTSPSSNQTR 21 0 Q8NHV4-2;Q8NHV4;Q8NHV4-3 Q8NHV4-2 NEDD1 Protein NEDD1 1 LVTSGAESGNLNT(0.036)S(0.123)PS(0.42)S(0.42)NQTR 314.94 1.5956999999999992e-118 50769000.0 46380.0 45908.0 52180.0 64045.0 52893.0 45069.0 43537.0 51225.0 37709.0 50642.0 True False 43802.385273850516 49428.99598251411 48822.7956092884 55321.960516212675 46248.108470580475 51276.845654352226 45561.55676692885 51374.056269244735 45251.85367749281 49179.83387628216 0.8906574467909089 1.0050663470490517 0.9927401489827734 1.1248911628164866 0.9403876513068996 1.0426396677822327 0.9264276264442958 1.0446163034727285 0.9201302670385048 1.0 15.585779241236827 -10.142282763506767 15.112939522966641 0.9999999820287894 0.9923364013690715 0.0 0.06752152321409254 0.0 0.0 0.06202749945879767 0.015043878350680303 7.20638128262714e-11 10.142282763506767 -0.007663580659717839 LVVPAS(ph)QCGSLIGK ddPTM_A459_Selumetinib_30min_R2 1 LVVPASQCGSLIGK 14 0 H3BRU6;F8VZX2;F8W0G4;J3QT27;E9PFP8;P57721-2;P57721-3;P57721-5;P57721-4;P57721;F8VXH9;F8W1G6;H3BND9;Q15366;Q15366-2;Q15366-6;Q15366-3;Q15366-5;Q15366-8;Q15366-4;Q15366-7 H3BRU6;Q15366;Q15366-5 PCBP2;PCBP3 Poly(rC)-binding protein 3;Poly(rC)-binding protein 2 1 LVVPAS(0.982)QCGS(0.018)LIGK 97.223 0.011246 3709500.0 32431.0 27724.0 31451.0 33910.0 32958.0 25446.0 23142.0 22416.0 23276.0 29740.0 True False 30628.614851579256 29850.34165328963 29427.47690125964 29291.399501987216 28817.52139174164 28950.955524210563 24218.148855003048 22481.22684883142 27931.850385778525 28881.328926200225 1.0604988063341485 1.0335515283789571 1.0189100708092407 1.0141984663113957 0.9977906994992637 1.0024107823496715 0.8385399756668784 0.778400014288718 0.9671248320031298 1.0 14.817849506508914 -7.173008928021583 5.3128644296992045 0.877964924505724 1.0219289641092817 0.4984270415445149 0.06062811453687891 0.16659116264180832 7.642127484546171 0.02312900865563167 0.01774277015005439 6.71415050149439e-08 7.173008928021583 0.14396403960355764 LVVPASQCGSLIGK ddPTM_A459_Selumetinib_30min_R2 1 LVVPASQCGSLIGK 14 0 H3BRU6;F8VZX2;F8W0G4;J3QT27;E9PFP8;P57721-2;P57721-3;P57721-5;P57721-4;P57721;F8VXH9;F8W1G6;H3BND9;Q15366;Q15366-2;Q15366-6;Q15366-3;Q15366-5;Q15366-8;Q15366-4;Q15366-7 H3BRU6;Q15366;Q15366-5 PCBP2;PCBP3 Poly(rC)-binding protein 3;Poly(rC)-binding protein 2 0 126.12 0.018337 2631100.0 22556.0 22461.0 26725.0 21168.0 19917.0 17179.0 18541.0 23589.0 17990.0 23487.0 False True 21302.427818822172 24183.6864765019 25005.542595979903 18284.88188316324 17414.84839976087 19545.251314564703 19403.19323829452 23657.640084630817 21588.502682598202 22808.869283445347 0.9339536981907056 1.0602755522850225 1.0963078566165005 0.8016566562742499 0.7635121313269373 0.8569145217887072 0.8506863271989259 1.0372123137994178 0.9464959623521151 1.0 14.477307308461686 -5.756235453449233 24.999823514236702 0.8865732919220778 1.0331886895868774 0.3308200939749293 0.08845124005178367 153.03673238919785 735182.5985625548 0.026312004350299227 0.04388518137360797 1.7529298904284832e-06 5.756235453449233 0.14661539766479958 LVVPATQCGSLIGK ddPTM_A459_Selumetinib_30min_R2 1 LVVPATQCGSLIGK 14 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 158.4 0.0042393 4013800.0 23157.0 20208.0 27924.0 27454.0 28308.0 19913.0 18689.0 17367.0 19113.0 20992.0 False True 21870.026644815793 21757.888621038714 26127.40024135241 23714.717839208406 24751.69596326908 22655.83499778373 19558.075531550952 17417.53509473838 22936.13406183988 20385.90641623387 1.0728012872363661 1.0673005250192014 1.2816403503425498 1.1632898412760155 1.2141572446128082 1.111347934950896 0.959392000150472 0.8543910061741631 1.1250975842592503 1.0 14.315284484187217 -7.149646630878959 4.003350194835318 0.9728591547804637 1.16157707245179 0.48368795041427126 0.08514884677671081 0.19757983768158413 5.505079037543024 0.03449522877885871 0.026195584875270527 7.085220477101215e-08 7.149646630878959 0.18871791767132629 LWAQDGSEDEPPKDS(ph)DGEDPETAAVGCR ddPTM_A459_Selumetinib_30min_R2 2 LWAQDGSEDEPPKDSDGEDPETAAVGCR 28 1 H7BY14;A0A087WYU3;Q96NU1-6;Q96NU1;H7C3J6;A0A087X1J5;Q96NU1-1;Q96NU1-2;A0A087WXB3;A0A087X223;A0A087WYW1;Q96NU1-4;Q96NU1-5 H7BY14;A0A087WXB3 SAMD11 Sterile alpha motif domain-containing protein 11 1 LWAQDGSEDEPPKDS(0.999)DGEDPET(0.001)AAVGCR;LWAQDGS(0.02)EDEPPKDS(0.978)DGEDPET(0.003)AAVGCR 86.508 1.5885e-05 13808200.0 69795.0 65442.0 63192.0 63517.0 58584.0 49701.0 58049.0 51301.0 41174.0 54514.0 True False 65916.07331152206 70461.19097080432 59126.295518247396 54865.87502706343 51224.15417239492 56546.86160924265 60748.39352191134 51450.277416662255 49409.950497681966 52940.03917561799 1.2451081324828392 1.3309621992734728 1.1168540189799963 1.0363776808902023 0.9675881425487624 1.0681303317827127 1.1474943061600444 0.9718594511421923 0.9333191147398728 1.0 15.692071641977186 -5.462129526747746 2.9865633896410873 1.0226042849517112 1.2882502417123927 0.756509208009235 0.060518316839338206 0.13031695303020274 2.2666473503582223 0.017863496214397697 0.04107176627107941 3.4504081682133447e-06 5.462129526747746 0.2656459567606815 LWCTYHEK ddPTM_A459_Selumetinib_30min_R2 2 LWCTYHEK 8 0 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 ; 104.2 0.020791 9386400.0 60426.0 101359.0 94399.0 84779.0 95215.0 78867.0 57255.0 57533.0 56605.0 99987.0 False True 57067.76482444356 109132.90937944657 88325.47111386003 73231.95394806776 83253.24046709992 89730.21336665536 59917.47094863018 57700.41150489914 67927.5816758461 97100.1155125751 0.5877208747197928 1.1239215195919428 0.9096330179176904 0.75419018362119 0.8573958952326693 0.9240999652058571 0.6170689976251417 0.5942362807738015 0.6995623158352374 1.0 16.5671853914588 -7.257083338985764 24.78715058350212 0.6939032542451684 0.8689102282889065 0.1186472187598323 0.16482111481519873 530.3767893831434 3018012.4862874 0.06222537587203971 0.04647392233109727 5.532439342252725e-08 7.257083338985764 0.1750069740437381 LWPTFFER ddPTM_A459_Selumetinib_30min_R1 1 LWPTFFER 8 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 0 143.85 0.029437 9828400.0 2105.5 3407.4 1627.8 2317.1 2172.4 2066.2 2575.0 2048.1 1310.4 1945.4 False True 2154.5540534101797 3008.4600239427173 1406.753700865365 1912.4619823539092 1975.9068035683702 2045.4159039594977 2380.7656768556076 1993.777734833607 2223.653092170715 2195.1110398006945 0.981523947693235 1.3705274901336522 0.640857649275497 0.87123701155799 0.9001397960021982 0.9318052102481392 1.0845764217338953 0.90828103849117 1.0130025551566684 1.0 11.100078205068716 -5.249591302325778 24.96437640604951 0.9194906545922742 1.1760256797540711 0.347626366264859 0.1409815676432975 801.6371234776028 1689073.9872629968 0.03525939549409292 0.09167620622758446 5.628707718587898e-06 5.249591302325778 0.25653502516179694 LY(ph)S(ph)LS(ph)VLYK ddPTM_A459_Selumetinib_30min_R1 1 LYSLSVLYK 9 0 O15498-2;O15498 O15498-2 YKT6 Synaptobrevin homolog YKT6 3 LY(1)S(1)LS(0.999)VLY(0.001)K 59.265 0.046371 0.0 1297.7 1413.2 1387.2 1442.1 1068.9 1398.4 1262.7 1152.1 662.84 1024.3 True False 1327.9338851153598 1247.7418870211445 1198.825859344166 1190.2643065696666 972.2181837296226 1384.3333656456105 1167.4535223943979 1121.5425654517835 1124.7910680818354 1155.7788825269104 1.1489515037790468 1.0795679916673793 1.037244993370307 1.0298373889366794 0.8411800893991384 1.197749315698696 1.0101011015549644 0.9703781427462361 0.9731888037465043 1.0 10.174649700151965 -4.9683108171285815 1.409311155319136 1.0046678477295796 1.1773732218383224 0.24300818715869565 0.08185715736410676 1.3307968392079539 3.1011529560356808 0.024302547980046482 0.29692612248122713 1.0756950815161356e-05 4.9683108171285815 0.17270537410874276 LYDSS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 LYDSSPSR 8 0 E9PP00;Q9C0D7;Q9C0D7-2 E9PP00 ZC3H12C Probable ribonuclease ZC3H12C 1 LYDS(0.075)S(0.923)PS(0.001)R;LYDS(0.021)S(0.979)PSR 131.62 0.0040409 12059000.0 6751.0 7027.5 7082.299999999999 7952.0 7367.299999999999 5605.9 6249.3 5483.5 3687.3 5507.0 True False 6908.28516484071 6204.717033003888 6120.562560289202 6563.332477527211 6700.929015802454 5549.50973574995 5777.910269659706 5338.05976708173 6257.078790263334 6213.877092722539 1.1117511759174374 0.9985258704699231 0.9849828808904794 1.0562378977875089 1.078381325509372 0.8930832800425565 0.9298398058800647 0.8590546107410889 1.006952454465408 1.0 12.601277990641748 -6.762203250596471 24.99999953643034 0.9284802986556933 1.0405213431890812 0.4976654618286155 0.05380511687098857 16.96557285851997 555236.9408982837 0.018112347097459132 0.01692626822155366 1.7290069914639833e-07 6.762203250596471 0.11204104453338792 LYDSS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 LYDSSPSR 8 0 E9PP00;Q9C0D7;Q9C0D7-2 E9PP00 ZC3H12C Probable ribonuclease ZC3H12C 1 LYDS(0.046)S(0.954)PSR 99.013 0.018995 5213800.0 47427.0 35929.0 41216.0 50386.0 52151.0 35346.0 32443.0 36099.0 31320.0 38374.0 True False 44791.1972053236 38684.63877005638 38564.207432587784 43523.339879301886 45599.325144144605 40214.590660958376 33951.66378458492 36204.042113488846 37584.87515391749 37266.042912374185 1.201930596995333 1.0380667156160857 1.0348350513969526 1.1679088112907734 1.2236159672591198 1.0791215680054167 0.9110616832706773 0.9715021849413289 1.0085555700746922 1.0 15.185574014452513 -7.073511765685202 5.79480753145133 0.9719544445424819 1.1269954386823133 0.5948822080595986 0.06241673902790413 0.17637445414350622 10.556062169723694 0.02576333232152513 0.020041908155202206 8.442833687035942e-08 7.073511765685202 0.1550409941398314 LYDSVSST(ph)DGEDSLER ddPTM_A459_Selumetinib_30min_R1 1 LYDSVSSTDGEDSLER 16 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 LYDS(0.001)VS(0.074)S(0.379)T(0.546)DGEDSLER 115.26 0.0047106000000000006 2015700.0 778.02 934.77 1184.1 1160.5 1199.1 1170.0 995.96 840.79 644.75 1061.2 True False 796.1463522366123 825.3266938372166 1023.3057237957225 957.8404602829883 1090.641616718299 1158.2308622750031 920.8339353480038 818.4895179291772 1094.0936593231593 1197.4153569633484 0.6648873739649069 0.6892568138847404 0.854595456659944 0.7999233137547832 0.9108298222299168 0.9672757707169237 0.7690179769225973 0.6835468688199147 0.9137127338150953 1.0 10.225707962832203 -5.232707642548092 4.488104956771724 0.8515222637742715 0.6712598509085544 0.4014314249851114 0.08983034734149044 0.21615513859221316 10.865278333621047 0.024151049081649216 0.06511752198015623 5.851838844454192e-06 5.232707642548092 -0.1802624128657171 LYEALT(ph)PVH ddPTM_A459_Selumetinib_30min_R1 3 LYEALTPVH 9 0 G5E9W3;Q9UKF6 G5E9W3 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 LYEALT(1)PVH;LYEALT(1)PVH;LYEALT(1)PVH 115.71 0.018894 28301800.0 12848.0 14844.7 16496.2 17103.800000000003 15149.6 12415.400000000001 14326.5 13246.5 7550.299999999999 11744.0 True False 13147.3334021439 13106.675622886196 14256.10664714045 14116.94240808977 13779.321354879121 12290.51234828126 13245.840570668683 12895.15978930393 12812.307647906393 13251.456796247228 0.9921424945419726 0.9890743202360941 1.0758142947104303 1.065312487913604 1.0398344549394285 0.9274838636429691 0.9995761805162331 0.9731126160374911 0.9668603116553041 1.0 13.693863350334082 -6.73377677239413 24.995692046797476 0.9733617205553868 1.0342630989390575 0.4630556163659699 0.031751671305747436 206.23436516785125 186351.12554134478 0.011149735794807561 0.011147497487458646 1.8459640018988913e-07 6.73377677239413 0.06090137838367071 LYEALT(ph)PVH ddPTM_A459_Selumetinib_30min_R2 2 LYEALTPVH 9 0 G5E9W3;Q9UKF6 G5E9W3 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 LYEALT(1)PVH;LYEALT(1)PVH 125.16 0.011952 13246200.0 85499.0 79664.0 86738.0 83977.0 98680.0 70881.0 77565.0 76857.0 64514.0 79432.0 True False 80747.30785961497 85773.97263986655 81157.37151319397 72539.1877315949 86282.93618960689 80644.21435634553 81171.92619213177 77080.64114563867 77418.60267176991 77138.59177087879 1.0467822396791346 1.111946312095469 1.052098173560803 0.9403747989988553 1.1185443525581737 1.0454457685185559 1.052286855757401 0.9992487466531377 1.0036299716453578 1.0 16.235165188159186 -7.759847085183446 23.895319299518473 1.0010795126667977 1.0527248097447126 0.213372817037231 0.04534515262724672 38.92140895604097 584143.7832064691 0.023133071729370378 0.012437347235768616 1.7384128150723736e-08 7.759847085183446 0.051645297077914876 LYHS(ph)LGPVTR ddPTM_A459_Selumetinib_30min_R2 1 LYHSLGPVTR 10 0 Q86X27 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 LYHS(0.998)LGPVT(0.002)R 86.803 0.022852 7464300.0 23753.0 18399.0 22111.0 23189.0 25148.0 18274.0 14901.0 18377.0 15332.0 19042.0 True False 22432.90335079281 19810.1441378905 20688.402332636542 20030.618196743784 21988.68341402753 20791.077625144375 15593.926025771354 18430.474027523866 18398.82841187302 18492.207982942324 1.2131003161702205 1.0712698102986877 1.1187632299896282 1.0831923486487134 1.1890783098649143 1.1243155843976331 0.8432700973380562 0.9966616233456057 0.9949503287462784 1.0 14.174629873402505 -7.183403407288798 9.990173998190297 0.9585421847654632 1.1303042139889241 0.6827604079144629 0.05827584218308155 0.30746558539765634 38.03076069477245 0.02179387719482275 0.016877184094766552 6.555360693232359e-08 7.183403407288798 0.17176202922346095 LYINHT(ph)PPPLSK ddPTM_A459_Selumetinib_30min_R1 1 LYINHTPPPLSK 12 0 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;B7ZBA0 A0A0C4DG98 THOC2 THO complex subunit 2 1 LYINHT(1)PPPLSK 132.97 0.004229699999999999 9888300.0 1964.6 2631.2 3081.2 2821.6 2543.8 2392.2 2577.0 2288.4 1308.4 2039.3 True False 2010.3713575538536 2323.137880788305 2662.789963820102 2328.8605279917956 2313.713739144368 2368.1366399438143 2382.6148152453957 2227.7041982292003 2220.2592382449357 2301.0640194641496 0.8736703283996463 1.0095928931735223 1.15719942656797 1.012079850144334 1.0054973349603564 1.0291485242967224 1.0354404723603634 0.9681191741670739 0.9648837318146276 1.0 11.168085406980554 -7.766117115490115 24.867553931112536 0.974876077005436 1.0223617134028964 0.06996579045564832 0.06468178618546161 288.3940270701186 1533101.3941614537 0.035233638073247135 0.01781098792339113 1.713495169729786e-08 7.766117115490115 0.047485636397460396 LYKS(ph)EPELTTVAEVDESNGEEKSEPVSEIETSVVK ddPTM_A459_Selumetinib_30min_R1 1 LYKSEPELTTVAEVDESNGEEKSEPVSEIETSVVK 35 2 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 LY(0.177)KS(0.587)EPELT(0.115)T(0.115)VAEVDES(0.002)NGEEKS(0.002)EPVS(0.002)EIET(0.001)SVVK 50.534 0.0031779 6637900.0 284.41 273.38 722.28 447.84 365.17 395.69 455.08 374.23 169.62 347.29 True False 291.03619963447596 241.37254250908592 624.198343200046 369.63315099796085 332.14043797600004 391.7097178577746 420.7529492129899 364.3042047296425 287.8327514453574 391.8680543910677 0.7426892709759755 0.6159536093957951 1.5928788688070055 0.9432592089506808 0.8475823284246028 0.9995959442686924 1.0737107669233388 0.9296603809558877 0.7345144576600585 1.0 8.614224157075393 -8.006926113128822 23.820960921051217 0.8555339430033391 0.9803446863530849 0.026956959538696812 0.2506121002398402 658.1245624607603 2263462.630521623 0.14897916017091356 0.06700336591303652 9.841785306074367e-09 8.006926113128822 0.12481074334974585 LYNNHEIR ddPTM_A459_Selumetinib_30min_R1 2 LYNNHEIR 8 0 O60506-2;O60506;O60506-4;O60506-3;B7Z645;O60506-5 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 ; 129.42 0.0057317 12462600.0 6638.700000000001 7524.299999999999 8081.0 8588.7 7454.9 6564.9 7246.0 7500.1 4444.2 5915.9 False True 6793.36879333848 6643.3514580478295 6983.644585755628 7088.844774866443 6780.605611269496 6498.863066452283 6699.428386211935 7301.172984241758 7541.482808474582 6675.263390745822 1.0176929951193225 0.9952193747527276 1.0461976070393457 1.0619573131292444 1.0157809833645985 0.973574027874602 1.0036200811940414 1.0937655275690932 1.1297655788278906 1.0 12.704609048057918 -7.763078978968987 24.99717999519289 1.0838241790767877 1.0167252452789246 0.31882153413727354 0.03827349285298887 46.291414784182365 705711.3116378105 0.019847846996783165 0.010334036684877085 1.7255240669017888e-08 7.763078978968987 -0.06709893379786314 LYNNHEIR ddPTM_A459_Selumetinib_30min_R2 4 LYNNHEIR 8 0 O60506-2;O60506;O60506-4;O60506-3;B7Z645;O60506-5 O60506-2 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 ;;; 134.48 0.0039297 18713600.0 113686.0 91466.0 109155.0 126616.0 121896.0 87763.0 90467.0 99812.0 100940.0 104433.0 False True 107367.7872411163 98481.14809045562 102132.08613897818 109370.68237521689 106582.33471593374 99851.55661680791 94673.89475695975 100102.43639523385 121130.8204992474 101417.74794047954 1.0586686198566422 0.9710445172599635 1.00704352258855 1.0784175807118572 1.0509238952780258 0.9845570291642562 0.933504210846038 0.9870307557409218 1.1943749783355193 1.0 16.62995061815065 -8.217207524655407 24.997440174588103 1.097187979456041 1.0079686938160108 0.2563206096154528 0.06013752668838337 524.8570355683637 296621.496548633 0.04042663820823527 0.01527972247074244 6.06446474030851e-09 8.217207524655407 -0.08921928564003023 LYNSEESRPYT(ph)NK ddPTM_A459_Selumetinib_30min_R1 1 LYNSEESRPYTNK 13 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 LYNSEES(0.027)RPYT(0.973)NK 193.45 0.0019356 39812000.0 2810.5 6313.7 3189.8 3451.1 2465.7 3999.2 3186.0 2413.9 1868.1 1851.8 True False 2875.9791817189775 5574.489068840505 2756.6426803172003 2848.4301701702893 2242.6778703546915 3958.971678983072 2945.6774549366824 2349.87553054775 3170.0292593743234 2089.496568059487 1.3763981361261082 2.6678622755612023 1.3192855745521952 1.3632136150458591 1.0733101478302327 1.8947012115266426 1.409754627006796 1.124613252047634 1.5171258511892776 1.0 11.02893967373752 -1.5228787452894255 0.17358094582507488 1.0539930116268388 4.696413473815324 0.19619771069791614 0.4168057789626805 89.98928981983926 0.988579663417356 1.0263165757840582 85.57791406421397 0.02999999999937223 1.5228787452894255 3.642420462188485 LYNSEESRPYT(ph)NK ddPTM_A459_Selumetinib_30min_R2 2 LYNSEESRPYTNK 13 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 LYNSEES(0.174)RPYT(0.826)NK;LYNSEES(0.007)RPYT(0.993)NK 159.18 0.0037761 55371000.0 64310.0 79487.0 77577.0 63843.0 57948.0 66472.0 25121.0 33030.0 20226.1 77467.0 True False 60735.90765332741 85583.39730901142 72585.78027945115 55147.47326468207 50668.05417830712 75627.91462726265 26289.176276317165 33126.11183158913 24271.885164452433 75230.32642656211 0.8073327677584415 1.137618316631335 0.9648473391951516 0.7330484378333197 0.6735057068743142 1.0052849458401414 0.349449185256161 0.4403292316420557 0.3226343193944003 1.0 16.199026729823863 -6.701900485273774 0.9547613975664713 0.506587818756723 0.959101696501105 0.2915616865661881 0.23386911685795253 0.6049969868262829 1.1949188475863954 0.13377674607460813 0.1305178821324848 1.9865500655259614e-07 6.701900485273774 0.452513877744382 LYPPGDEEEAELADSSGLY(ph)HEGSPSPGSPWK ddPTM_A459_Selumetinib_30min_R2 1 LYPPGDEEEAELADSSGLYHEGSPSPGSPWK 31 0 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 LYPPGDEEEAELADS(0.095)S(0.095)GLY(0.57)HEGS(0.157)PS(0.074)PGS(0.008)PWK 85.00200000000002 9.1551e-06 7068900.0 35522.0 32762.0 40853.0 46640.0 47756.0 33895.0 31331.0 37199.0 32645.0 45776.0 True False 33547.82944583266 35274.740053566406 38224.56245738324 40287.55154151234 41756.464335943165 38563.72858182494 32787.95358119872 37307.242931374036 39174.91217751075 44454.327939668496 0.7546583426334178 0.7935051925976649 0.8598614404712174 0.9062683749530276 0.9393115647280338 0.8674909816241508 0.7375649368875202 0.8392263399416549 0.8812395551379667 1.0 15.440036261892315 -14.522878410630195 0.4231355674815729 3.9526249429151443 0.8411675344034307 0.3820797197616309 0.060602098746468054 1190.0400924243606 7.663247456979098 3268.7623235428573 0.03912451742294485 3.0000023116821786e-15 14.522878410630195 -3.1114574085117135 LYPPGDEEEAELADSSGLYHEGSPS(ph)PGSPWK ddPTM_A459_Selumetinib_30min_R2 1 LYPPGDEEEAELADSSGLYHEGSPSPGSPWK 31 0 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 LYPPGDEEEAELADS(0.001)S(0.001)GLY(0.002)HEGS(0.104)PS(0.662)PGS(0.231)PWK 111.33 1.2373e-11 6823200.0 29396.0 31019.0 43576.0 45013.0 46918.0 33272.0 33789.0 29522.0 33876.0 39633.0 True False 27762.288001511635 33398.057558194734 40772.3676019615 38882.151748243865 41023.74138775818 37854.91598685583 35360.25545163329 29607.90413236982 40652.14657452454 38488.69231109931 0.721310242943889 0.8677368742030099 1.059333667987562 1.010222728118801 1.0658647754558244 0.9835334409618091 0.9187180267342093 0.7692624081133445 1.0562101264947714 1.0 15.23214703463322 -4.925687000014095 3.4002791262068297 0.9762383428729895 0.7208014154371848 0.4864782712194463 0.08369026049239338 0.24044008315498017 5.09483144529712 0.022945370623544414 0.1310522459318961 1.1866236505273695e-05 4.925687000014095 -0.2554369274358047 LYPPGDEEEAELADSSGLYHEGSPSPGS(ph)PWK ddPTM_A459_Selumetinib_30min_R1 2 LYPPGDEEEAELADSSGLYHEGSPSPGSPWK 31 0 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 LYPPGDEEEAELADS(0.001)S(0.006)GLY(0.121)HEGS(0.211)PS(0.316)PGS(0.343)PWK;LYPPGDEEEAELADS(0.049)S(0.003)GLY(0.069)HEGS(0.176)PS(0.307)PGS(0.396)PWK 99.236 2.1036e-08 36209000.0 9213.4 9648.2 10079.5 11232.9 10891.3 8544.3 10392.4 8445.599999999999 2581.1 5397.700000000001 True False 9428.054293844389 8518.58425867351 8710.75926273034 9271.284882647804 9906.183838015191 8458.352099603686 9608.492901030759 8221.595252824913 4379.938183914705 6090.547373050376 1.5479814401513246 1.3986565963458029 1.4302095902371519 1.5222416500151765 1.626484982589307 1.3887671471090492 1.5776074484777323 1.3498943115037667 0.7191370357441398 1.0 12.57235617730903 -8.134641409916576 4.458127741989026 0.8668713892078062 1.492175716545001 0.8678173307700248 0.09806491063192065 0.07018096639313925 2.1515728841995667 0.06898778146450542 0.024235338332480972 7.334298646349936e-09 8.134641409916576 0.6253043273371948 LYREEGLAYIWMPT(ph)PDMS(ph)T(ph)EDEK ddPTM_A459_Selumetinib_30min_R2 1 LYREEGLAYIWMPTPDMSTEDEK 23 1 H0Y7S8;A0A1W2PPT8 H0Y7S8 EPM2A 3 LY(0.005)REEGLAY(0.021)IWMPT(0.993)PDMS(0.996)T(0.985)EDEK 54.834 0.017825 9253600.0 30011.0 18888.0 30143.0 34547.0 36479.0 34164.0 39901.0 36757.0 38122.0 26372.0 True False 28343.108763551714 20336.648865507676 28203.63219721693 29841.639003100903 31896.181893602254 38869.78089008607 41756.475562331565 36863.95678455107 45747.465217676974 25610.571837315136 1.1066956623848287 0.794072424258671 1.1012496080280274 1.165207836539636 1.2454302893435927 1.517724053058901 1.630439016652159 1.4394038922176473 1.786272696614371 1.0 14.644451845590979 -6.282047756353369 1.2993193999061912 1.5146259583658075 0.9692866035047112 0.49151656264910615 0.20812999034368979 0.32523088526424987 1.1168934959654053 0.07838630737817097 0.10959326661694567 5.223387478700582e-07 6.282047756353369 -0.5453393548610963 LYS(ph)EVAEER ddPTM_A459_Selumetinib_30min_R1 1 LYSEVAEER 9 0 Q9UPN4-2;Q9UPN4;I3L2X7 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 LYS(1)EVAEER 125.72 0.0049764 1238500.0 705.15 586.04 646.11 678.22 605.29 582.76 557.01 736.82 365.89 604.5 True False 721.5786230169501 517.4261643573956 558.3718108281856 559.7816087661599 550.541626372629 576.8979635037442 514.9942872486764 717.2771400713333 620.8886064517267 682.0934633286314 1.0578881954030614 0.7585854317271189 0.8186148099166919 0.8206816790684566 0.8071351742413327 0.8457755344677681 0.7550201181162076 1.0515818998924351 0.9102691050897576 1.0 9.413825626739992 -7.764044140502288 24.9999998253448 0.9856941314612206 0.8323805937276816 0.3885161990079259 0.08582657092800144 67.17984277484437 644751.9732259695 0.04212591127988929 0.02170123400496721 1.7216935778708114e-08 7.764044140502288 -0.15331353773353906 LYS(ph)GDHQR ddPTM_A459_Selumetinib_30min_R2 1 LYSGDHQR 8 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 LYS(1)GDHQR 103.26 0.010294 5279800.0 25472.0 12488.0 14782.0 19892.0 18487.0 10002.0 19416.0 22581.0 13610.0 13289.0 True False 24056.36821249506 13445.78944475115 13830.942213424702 17182.675284386016 16164.497784123065 11379.684710883997 20318.882472074114 22646.706971514202 16332.380295172967 12905.312041031431 1.864067148164238 1.041880227459926 1.0717247416761642 1.33144206275331 1.2525460626391138 0.8817829956147654 1.5744588280757423 1.7548360628174482 1.2655548539427361 1.0 13.655677404716787 LYS(ph)NAYLNDLAGCIK ddPTM_A459_Selumetinib_30min_R1 1 LYSNAYLNDLAGCIK 15 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 LYS(1)NAYLNDLAGCIK 151.41 0.00042304 0.0 841.11 959.03 1137.6 1259.3 1054.5 898.76 1054.2 1531.1 485.14 962.36 True False 860.7062264848423 846.7463217590492 983.1201683895063 1039.3868949886842 959.1206611870966 889.7192904087882 974.6808452587109 1490.490254286282 823.2471467763281 1085.8882801802176 0.7926287097803437 0.7797729630331035 0.9053603269632345 0.9571766395859655 0.8832590596041038 0.819346986838395 0.8975885116809158 1.3726000008388664 0.7581324541413222 1.0 10.084659966146045 -7.5492486802772465 24.999900803048003 1.066238638525627 0.8606306404867158 0.24031994622242026 0.147605809235938 273.94617044644167 259710.15139354244 0.06506922339776196 0.037568964136121506 2.8232628904789433e-08 7.5492486802772465 -0.20560799803891128 LYS(ph)PSQIGAFVLMK ddPTM_A459_Selumetinib_30min_R1 1 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 1 LYS(1)PSQIGAFVLMK 126.48 0.0016942999999999995 0.0 348.1 379.99 346.46 421.62 420.81 527.93 310.62 540.64 61.399 238.92 True False 356.21005271530913 335.50059414744175 299.41263496855504 347.99198178760344 382.7478098000395 522.6195035220875 287.1896833184034 526.3004709537821 104.18961859446712 269.58770927787674 1.3213141417665546 1.2444951405467284 1.110631622526739 1.2908302931158917 1.4197524465239002 1.9385880199137675 1.0652921978070724 1.9522420824137032 0.38647762864839647 1.0 8.074610914157802 -8.273787159650803 24.993021092178406 0.693238817295408 1.4033009289148954 0.45096475551727544 0.3195059489650638 771.2010392990366 1560963.7905275594 0.28864171153626356 0.07669322128332137 5.323691003986175e-09 8.273787159650803 0.7100621116194874 LYS(ph)VSYLLK ddPTM_A459_Selumetinib_30min_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 LYS(1)VSYLLK 146.11 0.0017805 9182200.0 1841.0 1616.5 2640.3 2502.8 2570.5 1730.6 1932.9 2148.2 1006.0 1743.7 True False 1883.891718037587 1427.2394285095381 2281.7617621297604 2065.7329633746344 2337.998728858636 1713.191735259078 1787.0997968132833 2091.2227576629816 1707.108524667077 1967.5208800763187 0.9574951590676447 0.7253998892525992 1.159714128188186 1.0499166663453687 1.1882967812610692 0.8707362410266389 0.9083002955190813 1.0628719516216085 0.867644426015372 1.0 10.942163230901947 -5.2554962602181465 24.994155432098907 1.0143772645305553 0.8414475384567803 0.258776018731086 0.11642251444088372 649.2186181081307 2730309.7432561796 0.030069430929252523 0.07529086883272244 5.55269398615913e-06 5.2554962602181465 -0.172929726073775 LYSGS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 LYSGSPTR 8 0 Q6PJI9-3;Q6PJI9;H3BMH3;Q6PJI9-4 Q6PJI9-3 WDR59 WD repeat-containing protein 59 1 LYS(0.042)GS(0.958)PTR;LYS(0.007)GS(0.992)PT(0.001)R 125.71 0.0050199 83596000.0 6580.8 7045.0 7691.6 7291.8 7609.2 5752.4 5909.799999999999 6268.9 3044.5 5174.9 True False 6734.119835992268 6220.168124868357 6647.122966934536 6018.42401403834 6920.94920351337 5694.536078761308 5464.019027992724 6102.628407742977 5166.294138517813 5839.148822794599 1.1532708003097853 1.0652525417037415 1.138371904649151 1.0307022815626645 1.1852667937655037 0.975233934187675 0.935756082575347 1.0451229439331668 0.8847683618458007 1.0 12.51154236633052 -6.819558267464054 10.523411936830632 0.9687338679378008 1.1084415039737447 0.6274275160476858 0.056307854756737226 0.31221461762801545 54.8358909073584 0.01835145864700961 0.01619704539156979 1.515101515263835e-07 6.819558267464054 0.13970763603594394 LYSGS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 3 LYSGSPTR 8 0 Q6PJI9-3;Q6PJI9;H3BMH3;Q6PJI9-4 Q6PJI9-3 WDR59 WD repeat-containing protein 59 1 LYS(0.028)GS(0.965)PT(0.007)R;LYS(0.032)GS(0.962)PT(0.006)R;LYS(0.009)GS(0.987)PT(0.004)R 99.013 0.018995 76494000.0 237301.0 203490.0 224091.0 276231.0 248564.0 213445.0 168186.0 192794.0 175618.0 190524.0 True False 224112.7604111688 219097.0286765227 209673.22903183245 238607.86127494666 217337.16812964607 242845.1112892052 176006.98225423638 193354.9986212352 210746.50717690543 185023.0770791989 1.2112692316496152 1.1841605497823304 1.133227445688205 1.2896113557381323 1.174648976552342 1.3125125531517112 0.9512704308711546 1.0450317964308302 1.1390282255801834 1.0 17.4973456971318 -7.263942486310896 24.99997280731838 1.0375852631194955 1.2135426664295899 0.6495996364255128 0.0660471511886489 149.26351471819794 1490765.0388259806 0.02654526296177226 0.01883783112187624 5.4457476619247215e-08 7.263942486310896 0.17595740331009435 LYSILQGDS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 LYSILQGDSPTK 12 0 O15042-2;O15042;O15042-3 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 LYSILQGDS(0.913)PT(0.087)K 204.17 3.6368e-05 32169000.0 1709.2 2727.2 1399.9 1540.6 1496.8 1510.5 1884.4 1679.2 960.53 1828.6 True False 1749.0210344757436 2407.8981561591163 1209.801269100273 1271.5631306436642 1361.4147042815039 1495.3057414242664 1742.258190860856 1634.6621611896855 1629.9492556644814 2063.3186220723505 0.8476737503193116 1.1670025804064512 0.5863375904033551 0.6162708546518787 0.659817969807363 0.7247090805211728 0.844396096765206 0.7922490223772942 0.7899648838662626 1.0 11.010750907141896 -10.332714754324263 22.577390246531966 0.9999999999999806 0.7787073149725805 0.1520587946530395 0.15511186589138404 0.0 0.0 0.16101317683715435 0.03905143148328485 4.6482047020473466e-11 10.332714754324263 -0.22129268502740007 LYSILQGDSPT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 LYSILQGDSPTK 12 0 O15042-2;O15042;O15042-3 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 LYSILQGDS(0.164)PT(0.836)K 191.06 0.000328 22100000.0 4363.6 5788.3 4075.9 4435.8 3613.4 3652.8 4280.7 4278.7 2983.6 4932.4 True False 4465.26338991245 5110.603145092333 3522.415167316097 3661.170800278572 3286.5686079975844 3616.056148477038 3957.8033525886594 4165.214976823668 5062.951286477829 5565.521585644571 0.8023081612745745 0.9182613105435379 0.6328993811472475 0.6578306712028597 0.5905230188082993 0.6497245752858299 0.7111289196680541 0.7483961588734496 0.9096993351956362 1.0 12.442301184046231 -8.339273585324237 2.1294313555054525 0.9986293287266864 0.7052286885413329 0.5553742298513717 0.08866285397411934 0.25129477679072754 2.198895585804834 0.09400136004558567 0.026728598604746343 4.578533695201735e-09 8.339273585324237 -0.2934006401853535 LYSILQGDSPT(ph)KWR ddPTM_A459_Selumetinib_30min_R1 2 LYSILQGDSPTKWR 14 1 O15042-2;O15042;O15042-3 O15042-2 U2SURP U2 snRNP-associated SURP motif-containing protein 1 LYSILQGDS(0.127)PT(0.873)KWR;LYSILQGDS(0.006)PT(0.994)KWR 132.4 0.0011224 70692000.0 5644.2 5188.5 7943.700000000001 8635.4 5474.9 5765.5 4947.2 5580.4 3573.8999999999996 4210.6 True False 5775.698878298617 4581.028007931787 6864.989171620712 7127.389496534012 4979.696261672105 5707.504304655156 4574.028720986428 5432.389664306166 6064.647272671635 4751.071524717179 1.215662371793578 0.9642094386706767 1.4449349238179212 1.5001646385355754 1.0481206683093527 1.2013088573729505 0.9627362369078858 1.1434030483532964 1.2764798932452717 1.0 12.214037210539038 LYSLLGIDLTAPSNNSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 LYSLLGIDLTAPSNNSSPR 19 0 A3KN83-3;A3KN83-2;A3KN83;A3KN83-4 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 1 LYSLLGIDLT(0.001)APS(0.253)NNS(0.253)S(0.494)PR 111.63 0.00060603 2048600.0 306.27 786.47 546.13 636.71 554.08 441.95 447.9 379.44 338.09 499.05 True False 313.4054951023205 694.3897267800165 471.968545677357 525.5205510269554 503.96356183076955 437.5043842584936 414.1145423936414 369.37601860517753 573.7140368833922 563.1079286586493 0.5565638115749281 1.2331378967333793 0.8381493522948775 0.9332501360418973 0.8949679736018555 0.7769458783872046 0.7354088289612305 0.6559595413352629 1.01883494741409 1.0 9.137267654207529 -6.666646822099074 5.963692087462001 0.8098446404381385 0.9111289673493884 0.004671183576998916 0.18586156285889963 0.6500396382018596 33.72238234385011 0.05890183403399237 0.058617146941189226 2.1545331366007873e-07 6.666646822099074 0.10128432691124989 LYSNAYLNDLAGCIK ddPTM_A459_Selumetinib_30min_R1 2 LYSNAYLNDLAGCIK 15 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 206.49 2.8199e-05 36840000.0 5427.6 6325.0 5998.4 7114.5 6148.700000000001 6385.9 5936.700000000001 5379.0 4494.6 5166.0 False True 5554.052519728849 5584.466059587277 5183.8502268526845 5872.086130705142 5592.551170641153 6321.663643933289 5488.8899393354095 5236.331446545567 7627.007927404225 5829.106421101254 0.9528137107984999 0.9580312411816014 0.8893044409152053 1.0073732930056487 0.9594182652758274 1.0844996106176732 0.9416348824007968 0.8983077453501529 1.3084351831002092 1.0 12.509059025608869 -8.243888716884028 24.984371804950552 1.1542176365788428 0.9638137080991368 0.4435997438370718 0.08633481403179834 608.81586860504 866687.4948481035 0.05521586069506369 0.02076569471917424 5.703103892343525e-09 8.243888716884028 -0.190403928479706 LYSNAYLNDLAGCIK ddPTM_A459_Selumetinib_30min_R2 1 LYSNAYLNDLAGCIK 15 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 218.31 3.9856e-08 6591200.0 20858.0 19415.0 22807.0 24525.0 24362.0 16273.0 19317.0 22664.0 14366.0 17825.0 False True 19698.795861189596 20904.0680709356 21339.62245038406 21184.65269201524 21301.427760956674 18514.458038413846 20215.278775909348 22729.94848777281 17239.601419577866 17310.345935088062 1.1379781741542292 1.2076054487486043 1.2327669551148979 1.2238145194472376 1.2305604891337667 1.0695602564986901 1.1678148346494328 1.3130845895863477 0.9959131657001263 1.0 14.079346935787745 -8.28470321350515 24.758592976976626 0.9979564587935693 1.1960559411014162 0.6314397595395751 0.06108845910421046 525.3245031200403 559071.6849624546 0.059938911636557186 0.015515599131053725 5.191546956749526e-09 8.28470321350515 0.1980994823078469 LYSS(ph)GSSTPTGLAGGSR ddPTM_A459_Selumetinib_30min_R2 1 LYSSGSSTPTGLAGGSR 17 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 LYS(0.077)S(0.492)GS(0.239)S(0.116)T(0.073)PT(0.003)GLAGGSR 73.593 0.024761 17699000.0 67561.0 50096.0 64262.0 77054.0 68924.0 66504.0 75031.0 75687.0 63182.0 59880.0 True False 63806.23008811153 53938.20211597165 60127.452883175334 66559.11227443602 60265.15093162213 75664.32233679549 78520.09017110588 75907.23663934271 75820.16545258019 58151.108813075676 1.0972487264725082 0.9275524270629777 1.033986352288699 1.1445888759986937 1.0363542873334015 1.3011673187525161 1.3502767492105001 1.305344613175707 1.3038472868385185 1.0 15.827519080514913 -6.759286643608653 24.999710565986593 1.277345599564115 1.0458510622567807 0.4766747823700015 0.10531367982969804 43.737219881958104 507920.8316373953 0.03439819635685196 0.03280366816309006 1.74065762306076e-07 6.759286643608653 -0.23149453730733427 LYSSGSS(ph)TPTGLAGGSR ddPTM_A459_Selumetinib_30min_R1 2 LYSSGSSTPTGLAGGSR 17 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 LYSSGS(0.044)S(0.432)T(0.432)PT(0.092)GLAGGSR;LYSS(0.002)GS(0.078)S(0.451)T(0.451)PT(0.017)GLAGGSR 202.32 3.6525e-08 21646500.0 5329.0 6051.3 3642.0 3981.2 5689.8 3876.7 4819.3 4574.4 1991.5700000000002 3882.5 True False 5453.155331571054 5342.810982826954 3147.436404073999 3285.9581563796914 5175.158594615778 3837.7039177619686 4455.776320959312 4453.0720522547 3379.5488314823197 4380.85669375254 1.244769165662894 1.219581318522982 0.7184522626733032 0.7500720489363956 1.1813120027404636 0.8760167670480635 1.0171015927806115 1.0164843005718824 0.7714356044336791 1.0 12.096997306765532 -5.168607907188596 8.590360813424253 0.922802538287553 1.2359451193607784 0.4595749616467234 0.13688531572469392 0.3101474686194567 26.260579006250413 0.03547873913362697 0.09461080884074184 6.782535769573037e-06 5.168607907188596 0.31314258107322546 LYSSGSSTPT(ph)GLAGGSR ddPTM_A459_Selumetinib_30min_R2 1 LYSSGSSTPTGLAGGSR 17 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 LYS(0.052)S(0.112)GS(0.045)S(0.206)T(0.281)PT(0.303)GLAGGSR 102.72 0.008117000000000001 20163000.0 18572.0 16103.0 20502.0 21517.0 24629.0 17789.0 16591.0 15246.0 17550.0 16867.0 True False 17539.842589606542 17338.048320694088 19182.92364088982 18586.347481104654 21534.884833946384 20239.27327753604 17362.51437444282 15290.363335888824 21060.490387971022 16380.005884270997 1.0708080762320902 1.0584885282210466 1.1711182386882013 1.1346972407960068 1.314705561530072 1.2356084253285238 1.0599821817594879 0.9334772797958205 1.2857437620455612 1.0 13.99964825479498 -13.155018756534922 15.510103399401114 1.0091278196924787 1.1306101630444938 0.0 0.11845940766681276 0.0 0.0 0.0 0.027733964863038998 6.998117715165169e-14 13.155018756534922 0.12148234335201513 LYTSAPNT(ph)SQGK ddPTM_A459_Selumetinib_30min_R2 1 LYTSAPNTSQGK 12 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 LYT(0.041)S(0.001)APNT(0.876)S(0.082)QGK 185.32 0.00024443 8196400.0 52804.0 48098.0 57581.0 65466.0 62224.0 60640.0 78966.0 70033.0 70383.0 52307.0 True False 49869.36507116001 51786.96194055421 53876.30114945252 56549.41786485094 54406.86483038207 68992.60956488755 82638.07546816059 70236.78443541274 84461.56666533138 50796.76100009268 0.9817430105645717 1.019493387392549 1.0606247345053008 1.1132484975714843 1.0710695674136153 1.3582088347082144 1.6268374959578586 1.3827020276998487 1.6627352808022007 1.0 15.63244888760828 -6.816686551306143 3.6159278179664134 1.4550235890008196 1.0480237589210044 0.5161570998162412 0.17191910363932378 0.16627113282021064 4.420093553445552 0.058515313927990226 0.05276645558774993 1.525153124165885e-07 6.816686551306143 -0.4069998300798152 LYTSAPNTS(ph)QGK ddPTM_A459_Selumetinib_30min_R2 1 LYTSAPNTSQGK 12 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 LYTSAPNT(0.102)S(0.898)QGK 90.412 0.024444 8713900.0 56754.0 54541.0 53828.0 65793.0 66844.0 66587.0 85879.0 91646.0 70407.0 62664.0 True False 53599.839884262896 58724.119323043924 50364.76508349508 56831.87990074443 58446.45912705809 75758.75483339661 89872.54366601026 91912.67468718799 84490.36733594732 60854.72749937498 0.8807835000955908 0.9649886169262208 0.8276228840892 0.9338942467752918 0.960425944355077 1.244911577891376 1.4768375007008832 1.510362110949096 1.3883944733269094 1.0 15.893081722603132 -6.827755725725562 2.7867244481379982 1.38579082351852 0.9045093052100879 0.6958714116422149 0.13604617774592184 0.1337916335879269 2.1141895379315256 0.049377243413741306 0.04408590656579269 1.486771660162592e-07 6.827755725725562 -0.481281518308432 MAAAGGTVSGPS(ph)SACKPGR ddPTM_A459_Selumetinib_30min_R1 2 MAAAGGTVSGPSSACKPGR 19 1 A0A087X2H1;Q9ULT8;G3V4V5;A0A087WVU6 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 MAAAGGTVS(0.026)GPS(0.579)S(0.394)ACKPGR;MAAAGGTVSGPS(0.862)S(0.137)ACKPGR 106.73 0.00044529 17535700.0 1819.73 2892.7 4729.9 5435.2 4263.3 3937.0 3203.2 2652.2 1724.97 1848.15 True False 1862.1261684218023 2554.0213392202527 4087.6055594809495 4486.044351340025 3877.6852677467505 3897.3973545099884 2961.5800450888846 2581.8550404402586 2927.1481031759145 2085.3780550054744 0.8929441661439724 1.2247282132320838 1.9601268698831775 2.1511899679639854 1.8594639271470472 1.8689164514583698 1.4201645778233292 1.2380752901101575 1.4036534508215253 1.0 11.026093236024874 -7.495841569654588 4.353453592954813 1.2496655257462124 1.684494476644045 0.23551676980567104 0.3583324409058548 0.3544385715473442 15.837366704140356 0.18525899834466208 0.11371147663775856 3.192702338429452e-08 7.495841569654588 0.4348289508978327 MAAAGGTVSGPS(ph)SACKPGR ddPTM_A459_Selumetinib_30min_R2 2 MAAAGGTVSGPSSACKPGR 19 1 A0A087X2H1;Q9ULT8;G3V4V5;A0A087WVU6 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 MAAAGGTVS(0.003)GPS(0.544)S(0.453)ACKPGR;MAAAGGTVS(0.057)GPS(0.567)S(0.376)ACKPGR 119.38 0.00024431 14034800.0 35513.0 35686.0 35862.0 40668.0 39823.0 39167.0 33007.0 30370.0 31807.0 34198.0 True False 33539.32962980277 38423.001451424556 33554.677963593305 35128.94824378695 34820.07871786298 44561.89872737384 34541.89090212972 30458.37167197586 38169.2887618344 33210.61488292518 1.0098978819885263 1.1569494147240031 1.0103600334375327 1.05776265713912 1.0484623317156734 1.341796858759299 1.0400858588104311 0.9171276045128465 1.149309908786382 1.0 15.019356813631708 -10.478679195746565 5.340412465502635 0.9999997841263671 1.0814059531978364 0.04775994284322416 0.10891332614415707 2.833785968416571e-07 5.539459826099014e-08 0.1067352832501288 0.025887039973543892 3.321397116199389e-11 10.478679195746565 0.08140616907146925 MAAAGGTVSGPSS(ph)ACKPGR ddPTM_A459_Selumetinib_30min_R2 1 MAAAGGTVSGPSSACKPGR 19 1 A0A087X2H1;Q9ULT8;G3V4V5;A0A087WVU6 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 MAAAGGTVS(0.003)GPS(0.457)S(0.54)ACKPGR 55.744 0.030908 2191300.0 9597.9 9625.3 11070.0 11034.0 8191.0 7560.7 6819.2 6636.7 4812.6 11532.0 True False 9064.4871414379 10363.529559782457 10357.768252104675 9531.150165288316 7161.97335153091 8602.117795798895 7136.306311988456 6656.011698235167 5775.254475279165 11199.041196265665 0.8093984996198125 0.925394359942009 0.9248799134303111 0.8510684082907464 0.6395166537934586 0.7681119878965426 0.6372247576308646 0.5943376385162886 0.5156918680864332 1.0 13.451087601064039 -6.175428211975058 4.49629964379418 0.6732155282730845 0.8896448116597528 0.3365384147101125 0.1259840862932814 0.23201569577980932 8.358646849777493 0.03667353316798903 0.04780111972698065 6.676852589051006e-07 6.175428211975058 0.21642928338666834 MADAALTT(ph)ATDET(ph)VDIY(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 MADAALTTATDETVDIYPR 19 0 J3QKX0 J3QKX0 BRIP1 3 MADAALT(0.017)T(0.839)AT(0.145)DET(0.999)VDIY(1)PR 63.894 0.030573000000000006 0.0 4126.9 5257.8 6762.9 6645.2 5694.5 3558.0 4082.2 4511.5 3256.1 5198.9 True False 3897.5434192896446 5661.056353508374 6327.782376888775 5740.112296390602 4979.106000524083 4048.0822036917857 4272.030388725843 4524.62771808097 3907.410983035464 5048.79424863559 0.7719750949135896 1.1212689752683513 1.2533254605490856 1.1369273560596844 0.9861970512800479 0.8017918743244011 0.846148640317505 0.8961798590433205 0.7739295345797508 1.0 12.301723169711744 -6.5498739404846855 4.380582900820468 0.8571055851160526 1.0859450790118566 0.36796496429909464 0.12761339641194416 0.21078357158340713 9.526711086312194 0.0436872752721615 0.04511162967652613 2.819201121614405e-07 6.5498739404846855 0.22883949389580394 MADGGS(ph)PFLGR ddPTM_A459_Selumetinib_30min_R1 1 MADGGSPFLGR 11 0 O60504-2;O60504;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 MADGGS(1)PFLGR 93.839 0.023034 4361300.0 2995.3 3399.1 2825.6 3134.7 3398.2 2510.4 2916.9 2435.6 1631.7 2662.5 True False 3065.0846621607757 3001.131791801282 2441.899039909801 2587.2834906067073 3090.83341000094 2485.1476552608265 2696.875884590336 2370.9999760562137 2768.875725347189 3004.257809946205 1.0202468816135524 0.9989594707436313 0.8128127459052945 0.8612055470209582 1.028817633349611 0.8272085195329246 0.8976845714311806 0.7892132187212886 0.9216505042211305 1.0 11.552792907491432 -6.795538838556021 24.999963198244657 0.8746355538378495 0.9355060888393022 0.09292108428674595 0.08276041163334504 442.0561219267879 324089.5866632348 0.029647342985354642 0.02614771335635159 1.6012574429609165e-07 6.795538838556021 0.060870535001452675 MADGGS(ph)PFLGR ddPTM_A459_Selumetinib_30min_R2 2 MADGGSPFLGR 11 0 O60504-2;O60504;E5RIA0;E5RJP2 O60504-2 SORBS3 Vinexin 1 MADGGS(1)PFLGR;MADGGS(1)PFLGR 125.36 0.0033649 10902700.0 60232.0 45965.0 59985.0 62276.0 69342.0 50044.0 53812.0 50908.0 38969.0 53370.0 True False 56884.5465678 49490.36769923021 56125.63040672986 53793.90136790783 60630.63803465467 56937.10674579866 56314.3646264551 51056.133851726925 46763.88888483432 51829.069428086936 1.0975413449536762 0.9548766405674777 1.0828986710750117 1.0379098440605248 1.1698191517557526 1.0985554511025737 1.0865401452864503 0.9850868328355294 0.9022714357185098 1.0 15.66147387044481 -7.878549520154984 4.254699674712555 0.9489997538081184 1.0740715112459702 0.46879435837700856 0.055702525735068016 0.19606405406195834 6.203808942047916 0.03405247796912188 0.01544215180778094 1.322666883152286e-08 7.878549520154984 0.12507175743785182 MAEESSSSSSSSS(ph)PTAATSQQQQLK ddPTM_A459_Selumetinib_30min_R2 3 MAEESSSSSSSSSPTAATSQQQQLK 25 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 MAEESSSSS(0.001)S(0.004)S(0.024)S(0.177)S(0.768)PT(0.024)AAT(0.002)SQQQQLK;MAEESSS(0.001)S(0.001)S(0.002)S(0.006)S(0.006)S(0.034)S(0.49)PT(0.434)AAT(0.019)S(0.007)QQQQLK;MAEESSSSS(0.001)S(0.003)S(0.003)S(0.016)S(0.484)PT(0.484)AAT(0.008)S(0.002)QQQQLK 125.83 4.8656e-08 23017700.0 95059.5 87143.0 106403.0 108415.0 118395.0 78508.1 80700.0 96075.0 86371.0 101032.0 True False 89776.47354332882 93826.5878910915 99557.14682282698 93648.68997369327 103521.16163527072 89321.87814942526 84452.70990401632 96354.56234392745 103647.61340737597 98114.94364733883 0.9150132508460531 0.9562925320360856 1.0146991184204515 0.954479373807736 1.0551008621822566 0.9103799567014065 0.8607527738849894 0.9820579695816893 1.0563896747464239 1.0 16.582185266085872 -8.00801658191706 24.8459602868356 1.0252045189870107 0.9547827242937325 0.24610832889036494 0.05259154370682179 519.1749335206997 1609080.3469035104 0.03263862724900642 0.014500963560345614 9.817104593473484e-09 8.00801658191706 -0.07042179469327825 MAGNEALS(ph)PTSPFR ddPTM_A459_Selumetinib_30min_R2 3 MAGNEALSPTSPFR 14 0 Q86WR7;Q86WR7-2;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 MAGNEALS(0.489)PT(0.489)S(0.023)PFR;MAGNEALS(0.49)PT(0.209)S(0.301)PFR;MAGNEALS(0.987)PT(0.012)SPFR 176.43 6.9275e-05 41808200.0 100391.0 94120.0 98615.0 108689.0 116184.0 82646.0 90652.0 103414.0 97997.0 143646.0 True False 94811.6701170143 101338.7013565004 92270.21826389352 93885.37070101684 101587.9272218614 94029.73631430905 94867.49762353027 103714.91761889067 117599.13826495723 139498.56674286997 0.6796605322245026 0.72644976735347 0.6614420521894689 0.6730203248186096 0.7282363510523577 0.6740552143996497 0.6800607335155946 0.7434837506973292 0.8430132367002827 1.0 17.08989077381331 -8.498296921335077 1.4865626130297123 0.9989561207851638 0.6889813131782502 0.9525122660301955 0.021876165024166193 0.07834960199109482 0.38201433999241025 0.02083866921183646 0.006178190953383565 3.174702826600741e-09 8.498296921335077 -0.30997480760691365 MAGNEALSPT(ph)SPFR ddPTM_A459_Selumetinib_30min_R1 3 MAGNEALSPTSPFR 14 0 Q86WR7;Q86WR7-2;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 MAGNEALSPT(0.737)S(0.263)PFR;MAGNEALS(0.25)PT(0.576)S(0.174)PFR;MAGNEALS(0.251)PT(0.575)S(0.174)PFR 206.49 1.7639000000000002e-05 128618000.0 9979.900000000001 11298.400000000001 11729.1 11939.7 10882.900000000001 10583.2 12848.6 13256.5 8381.5 8562.4 True False 10212.41225249502 9975.578075516347 10136.352643334527 9854.655530927013 9898.543616532053 10476.742616776768 11879.41975753279 12904.89455681935 14222.793339460342 9661.467444838834 1.0570249613531018 1.0325116896031472 1.0491524917107056 1.0199957291365072 1.0245383191577038 1.0843841969755283 1.2295668153266706 1.3357075030784438 1.4721152268704454 1.0 13.238026616021916 -7.2984558086215525 2.550518482170073 1.3009802924566922 1.0371665582140788 0.4722922024880343 0.11084717523474981 0.2215451185006803 2.8401775057166336 0.05008340441565543 0.03245110152178596 5.02972442910454e-08 7.2984558086215525 -0.26381373424261345 MAGNEALSPT(ph)SPFR ddPTM_A459_Selumetinib_30min_R2 3 MAGNEALSPTSPFR 14 0 Q86WR7;Q86WR7-2;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 MAGNEALS(0.016)PT(0.915)S(0.069)PFR;MAGNEALS(0.001)PT(0.499)S(0.499)PFR;MAGNEALS(0.134)PT(0.863)S(0.003)PFR 153.79 0.00083378 27089300.0 74169.0 72415.0 81580.0 88176.0 97284.0 70664.0 71378.0 84158.0 86089.0 128347.0 True False 70046.98390203151 77968.99764907539 76331.23161758824 76166.27668791582 85062.31419000537 80397.32457607545 74697.21843282378 84402.88584689313 103309.20552763753 124641.28862444578 0.5619886048602137 0.6255471081015718 0.612407272581884 0.6110838352884086 0.6824569541021432 0.6450296323421291 0.5992975462400144 0.6771663449437354 0.8288521939059574 1.0 16.927422528565906 -8.453566461458506 1.7260229303378487 0.9988261068899558 0.6216982257782634 0.9432052209939438 0.02998669775903118 0.07633273708627653 0.4951336586165229 0.02972226685233841 0.008585162612226043 3.519115642638294e-09 8.453566461458506 -0.3771278811116924 MAGNEALSPTS(ph)PFR ddPTM_A459_Selumetinib_30min_R1 1 MAGNEALSPTSPFR 14 0 Q86WR7;Q86WR7-2;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 MAGNEALS(0.045)PT(0.138)S(0.817)PFR 93.716 0.014083000000000004 32667000.0 4484.2 4839.1 5554.1 5281.5 5309.7 4647.0 4816.8 5551.4 3542.2 4083.6 True False 4588.673135265699 4272.535922363443 4799.883726487482 4359.185171033698 4829.438572503672 4600.255399138411 4453.464897972072 5404.158838511445 6010.854687948036 4607.769837632421 0.995855543345339 0.927245950409444 1.0416934646531246 0.9460509801143949 1.0481075970984588 0.9983691810227504 0.9665120122971174 1.172836107041368 1.3045041093104064 1.0 12.16985293928967 -7.7669728960425655 24.567549319329288 1.1790026830639384 0.9897296607813164 0.4962233830073708 0.07771878033426213 78.53216939824455 348654.53812166146 0.038338164648491005 0.019253111164180107 1.7101220390542102e-08 7.7669728960425655 -0.189273022282622 MAGNEALSPTS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 2 MAGNEALSPTSPFR 14 0 Q86WR7;Q86WR7-2;D3DRR9 Q86WR7 PROSER2;C10orf47 Proline and serine-rich protein 2 1 MAGNEALS(0.023)PT(0.21)S(0.767)PFR;MAGNEALS(0.058)PT(0.114)S(0.829)PFR 128.73 0.0011108 17818800.0 56776.0 55860.0 64382.0 71485.0 86556.0 58173.0 60716.0 62969.0 61148.0 88599.0 True False 53620.61721233585 60144.28238179047 60239.73221382147 61748.61968149679 75682.06145954212 66185.80270808387 63539.41430647159 63152.22936492085 73379.30861787184 86040.91666215243 0.6231990463663019 0.6990195445958871 0.7001288985606501 0.717665758071342 0.8796054760401344 0.7692363735264293 0.7384790489385991 0.7339790394481022 0.8528420135968848 1.0 16.392735274567244 -14.522878745003005 0.06829355373277786 1.8652672286035068 0.42730621640516686 0.7290743568153255 0.054156900508496676 193.1348705076342 0.9485539380821513 26.640461885654076 3.4692830640825365 3.0000000019157422e-15 14.522878745003005 -1.43796101219834 MALLQEFASRPLGAAPQAEHQGLPVPGS(ph)PGGQK ddPTM_A459_Selumetinib_30min_R1 1 MALLQEFASRPLGAAPQAEHQGLPVPGSPGGQK 33 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 MALLQEFASRPLGAAPQAEHQGLPVPGS(1)PGGQK 74.766 5.4535e-06 11974000.0 2018.9 2157.6 2029.6 3229.4 2430.7 1921.8 2232.6 2049.2 1248.4 1835.8 True False 2065.936441904446 1904.9871889589715 1753.9914677947806 2665.4459133458704 2210.8436141749394 1902.468436854788 2064.193184523427 1994.848559260303 2118.44362047155 2071.4428122062895 0.9973417705430261 0.9196426653603695 0.8467486804169158 1.2867581463699254 1.067296476227685 0.9184267244281162 0.9965002037999104 0.9630237183017348 1.0226898893796637 1.0 11.016420276021806 MALPPQEDAT(ph)ASPPR ddPTM_A459_Selumetinib_30min_R1 2 MALPPQEDATASPPR 15 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MALPPQEDAT(0.842)AS(0.158)PPR;MALPPQEDAT(0.805)AS(0.195)PPR 146.27 0.0035312 56746000.0 6998.6 8668.4 6925.799999999999 7318.7 8000.8 6909.1 8355.4 6947.799999999999 3781.1000000000004 6168.700000000001 True False 7161.6537630949815 7653.499698170171 5985.3144006962375 6040.626434013879 7277.129052655967 6839.600726960875 7725.145451028864 6763.521774364989 6416.250539382395 6960.512733226351 1.0288974444236663 1.099559758239621 0.8598956183392991 0.8678421641524554 1.0454874994938566 0.9826288650133063 1.1098529299648432 0.9716987862228862 0.9218071692842549 1.0 12.764977868097775 -5.216414574539196 24.99348001647168 0.9733980602314047 1.0642286227491937 0.20811829296982354 0.07334552170081769 773.8343742854531 429556.5723100249 0.019984883701206445 0.05287470823659172 6.075547567626412e-06 5.216414574539196 0.09083056251778898 MALPPQEDAT(ph)ASPPR ddPTM_A459_Selumetinib_30min_R2 5 MALPPQEDATASPPR 15 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MALPPQEDAT(0.616)AS(0.384)PPR;MALPPQEDAT(0.987)AS(0.013)PPR;MALPPQEDAT(0.735)AS(0.265)PPR;MALPPQEDAT(0.91)AS(0.09)PPR;MALPPQEDAT(0.5)AS(0.5)PPR 141.06 0.0039423 49644800.0 182731.0 151461.0 177400.0 183576.0 194685.0 153367.0 143881.0 156936.0 140407.0 158585.0 True False 172575.54255015048 163077.5716761257 165986.27713851587 158572.63211373676 170226.92979401734 174491.91212298977 150571.7515947926 157392.6577778466 168492.3232993645 154006.23899668668 1.1205750083531572 1.0589023713489567 1.0777893039910347 1.0296507021195962 1.105324893997831 1.133018462497119 0.9776990372320696 1.0219888415120166 1.094061671767658 1.0 17.232629272027488 -8.071623761413399 0.010078335659655628 2.714587736273977e-06 2.0945047640873837 0.22771383650696975 0.044147229274074634 1571.129066555796 15.690730751850289 1634.0184124320842 1624.1997069524857 8.479617033663173e-09 8.071623761413399 2.0945020494996474 MALPPQEDATAS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 9 MALPPQEDATASPPR 15 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MALPPQEDAT(0.06)AS(0.94)PPR;MALPPQEDAT(0.335)AS(0.665)PPR;MALPPQEDAT(0.407)AS(0.593)PPR;MALPPQEDAT(0.329)AS(0.671)PPR;MALPPQEDAT(0.002)AS(0.998)PPR;MALPPQEDAT(0.002)AS(0.998)PPR;MALPPQEDATAS(1)PPR;MALPPQEDATAS(1)PPR;MALPPQEDAT(0.004)AS(0.996)PPR 265.43 3.9573e-37 707006000.0 82256.29999999999 103011.0 81500.9 89528.7 93637.9 80427.4 92613.6 84193.0 47013.4 72803.1 True False 84172.71174710225 90950.42423148527 70433.52543239822 73894.19320683973 85168.36847811402 79618.37337823643 85627.68158836298 81959.9281425936 79778.30607712052 82148.0870472469 1.024646035868016 1.1071520652596059 0.8573970248618069 0.899524211249618 1.036766302654498 0.9692054464085631 1.0423575845304203 0.997709515687869 0.9711523292226706 1.0 16.325939359599012 MALPPQEDATAS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 12 MALPPQEDATASPPR 15 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MALPPQEDAT(0.177)AS(0.823)PPR;MALPPQEDAT(0.172)AS(0.828)PPR;MALPPQEDAT(0.174)AS(0.826)PPR;MALPPQEDAT(0.45)AS(0.55)PPR;MALPPQEDAT(0.382)AS(0.618)PPR;MALPPQEDATAS(1)PPR;MALPPQEDAT(0.003)AS(0.997)PPR;MALPPQEDATAS(1)PPR;MALPPQEDAT(0.001)AS(0.999)PPR;MALPPQEDAT(0.006)AS(0.994)PPR;MALPPQEDAT(0.001)AS(0.999)PPR;MALPPQEDAT(0.297)AS(0.703)PPR 254.89 1.207e-28 918090700.0 2885147.0 2687240.0 3138514.0 3360775.0 3560208.0 2611689.0 2689783.0 2840419.0 2522170.0 2871057.0 True False 2724802.079898531 2893342.667161527 2936585.4261956727 2903031.647339759 3112942.842376655 2971425.4531977535 2814863.2392038982 2848684.1490333243 3026674.475317885 2788162.124508058 0.9772753370212622 1.037723969395082 1.0532333828018707 1.0411990112848866 1.116485592790233 1.0657290790513232 1.0095766004642042 1.0217067809627263 1.08554464918424 1.0 21.410883022002324 -4.74422562744413 2.814277581451519 1.0511852951359706 0.9595418807219658 0.29387460874538673 0.03314233425550923 0.6509482756168762 6.51903748560508 0.008761039619083146 0.14536583673872064 1.8020812688446196e-05 4.74422562744413 -0.09164341441400481 MALPPQEDATAS(ph)PPRQK ddPTM_A459_Selumetinib_30min_R1 4 MALPPQEDATASPPRQK 17 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MALPPQEDAT(0.017)AS(0.983)PPRQK;MALPPQEDATAS(1)PPRQK;MALPPQEDAT(0.004)AS(0.996)PPRQK;MALPPQEDATAS(1)PPRQK 185.59 2.7224e-07 61092600.0 15161.24 10454.630000000001 40143.8 41795.1 26112.0 17998.66 14575.65 14724.150000000001 11342.400000000001 9572.86 True False 15514.46739336242 9230.597059374368 34692.49245410925 34496.370376194354 23750.17421044803 17817.60982187573 13476.196985576855 14333.617711220282 19247.224383880573 10801.629828552728 1.436308005330076 0.8545559518226096 3.211783129468488 3.1936264178399827 2.19875838992996 1.649529756590728 1.247607740635052 1.3269865695018723 1.781881502086194 1.0 13.398961392694446 -6.883445988153915 3.592109535870518 1.3745080938482557 2.2195242696548774 0.24913581121187778 0.6884009813057042 0.3918874357626328 9.7432082394329 0.285825956232184 0.2501762163231782 1.3078381805495213e-07 6.883445988153915 0.8450161758066217 MALPPQEDATAS(ph)PPRQK ddPTM_A459_Selumetinib_30min_R2 4 MALPPQEDATASPPRQK 17 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MALPPQEDAT(0.007)AS(0.993)PPRQK;MALPPQEDAT(0.027)AS(0.973)PPRQK;MALPPQEDATAS(1)PPRQK;MALPPQEDAT(0.04)AS(0.96)PPRQK 118.46 0.00084874 45445100.0 158400.0 328321.0 253034.0 342117.0 282978.0 111789.0 49367.3 65140.1 47229.4 251183.0 True False 149596.76212544044 353502.1649815946 236754.06792258838 295520.07441525743 247427.77378458274 127186.9200304951 51662.97726944915 65329.64690647589 56676.5996996945 243930.69413818943 0.6132756792004709 1.4491909934931424 0.9705792407923235 1.2114919586456063 1.0143363657400661 0.521405969346532 0.21179367136216773 0.2678205263888026 0.23234714228946762 1.0 17.896111780314996 -6.801799520399231 3.45111972373188 0.36686784026042885 1.086691621148105 0.5186734361488001 0.2897249846617805 0.16302369772318692 4.006564899516781 0.09920118073364957 0.09020677441902572 1.5783396968437719e-07 6.801799520399231 0.7198237808876762 MANS(ph)SPVLSK ddPTM_A459_Selumetinib_30min_R1 1 MANSSPVLSK 10 0 Q9NXE8 Q9NXE8 CWC25 Pre-mRNA-splicing factor CWC25 homolog 1 MANS(0.5)S(0.5)PVLSK 145.31 0.0009059 84473000.0 6160.6 6747.9 6706.4 6939.3 5750.7 5904.8 6007.6 6108.5 3035.6 5203.7 True False 6304.129993559133 5957.852730986399 5795.707715618309 5727.481521793835 5230.550200368548 5845.403073129433 5554.441895253494 5946.482736795609 5151.191488548092 5871.645583330357 1.0736564229041008 1.0146819399148996 0.98706702122355 0.9754474176803509 0.8908150408836181 0.9955306379057642 0.9459770376847325 1.0127455161254477 0.8772994581233514 1.0 12.519549173380838 -4.866474889951612 1.1603822994760926 0.9558708830084567 1.1160759326209084 0.43424430302318084 0.04211177053559159 1.27660277400651 1.6030021811528965 0.012487609120116002 0.2408409757990326 1.3599567910246089e-05 4.866474889951612 0.16020504961245174 MANS(ph)SPVLSK ddPTM_A459_Selumetinib_30min_R2 2 MANSSPVLSK 10 0 Q9NXE8 Q9NXE8 CWC25 Pre-mRNA-splicing factor CWC25 homolog 1 MANS(0.916)S(0.084)PVLSK;MANS(0.987)S(0.013)PVLSK 171.62 0.00016919 31727000.0 359900.0 361760.0 391670.0 436700.0 428770.0 335000.0 336220.0 372650.0 321980.0 361350.0 True False 339898.1987938505 389505.82875826163 366470.3786180526 377220.7066504809 374904.07934756525 381143.2091727789 351854.89620729047 373734.34980447154 386384.9968728719 350916.8865999484 0.9686002919014285 1.1099660450433249 1.044322438195559 1.074957407451638 1.0683557664609133 1.0861352751236764 1.0026730249901352 1.0650224143545861 1.1010726802479522 1.0 18.420769848303486 -4.741911081501463 24.790235923240427 1.0624681675410688 0.9685999371325957 0.3859722531936144 0.03508655005696393 1269.907937159312 1611994.1434419001 0.008282452188080979 0.31037066920120815 1.811710988721871e-05 4.741911081501463 -0.09386823040847303 MANSS(ph)PVLSK ddPTM_A459_Selumetinib_30min_R1 2 MANSSPVLSK 10 0 Q9NXE8 Q9NXE8 CWC25 Pre-mRNA-splicing factor CWC25 homolog 1 MANS(0.032)S(0.67)PVLS(0.298)K;MANS(0.087)S(0.906)PVLS(0.006)K 132.5 0.0024294 17462800.0 10643.6 11186.3 10907.3 11958.5 10620.6 9270.5 9984.2 9035.7 6054.1 9423.7 True False 10891.57517115962 9876.60279563022 9426.148569510255 9870.172463846722 9659.96860521922 9177.247186940534 9231.083755674463 8796.043883909977 10273.365526030771 10633.323689611287 1.0242869952130438 0.928834961102484 0.8864724562762594 0.9282302271574635 0.9084618212701423 0.8630647815138617 0.8681277863000817 0.8272149085900278 0.966148104385067 1.0 13.376304994389947 -4.764096587141195 2.5824892869685554 0.8977897490209453 1.0543762631978149 0.3383254255484116 0.04836326953628918 0.5471874009751263 4.54565755309209 0.012088023315368696 0.19339851189084106 1.7214856738031706e-05 4.764096587141195 0.15658651417686953 MANSS(ph)PVLSK ddPTM_A459_Selumetinib_30min_R2 3 MANSSPVLSK 10 0 Q9NXE8 Q9NXE8 CWC25 Pre-mRNA-splicing factor CWC25 homolog 1 MANS(0.021)S(0.979)PVLSK;MANS(0.291)S(0.709)PVLSK;MANS(0.003)S(0.989)PVLS(0.008)K 177.16 7.8291e-05 141738000.0 424410.0 416740.0 473130.0 493910.0 508960.0 342483.0 395670.0 396866.0 354679.0 404350.0 True False 400822.99124784145 448702.61796969903 442689.3309049952 426638.60595772654 445019.89463987027 389656.92449886835 414069.43900523154 398020.81435529643 425624.7105592682 392675.36487253086 1.020749013317796 1.1426808455767414 1.1273672109496855 1.0864919068610803 1.1333023012134498 0.9923131404623706 1.0544828528768173 1.0136128974744845 1.0839098874904802 1.0 18.582977565461064 -6.7563966808792415 24.999924611893572 1.0313157542365508 1.1049063239081611 0.4505333238979238 0.04034528556295702 114.25782797532939 566450.5896257528 0.01293034354001584 0.012556764635560044 1.752279253730329e-07 6.7563966808792415 0.07359056967161037 MAPALSGANLT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 MAPALSGANLTSPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MAPALSGANLT(0.619)S(0.381)PR 103.83 0.015456 13412000.0 25524.0 23301.0 24529.0 28014.0 31755.0 21575.0 19265.0 22224.0 22173.0 24987.0 True False 24105.47826066754 25088.111775476187 22950.83084515589 24198.44487315451 27765.653006698107 24546.76041164987 20160.860672873292 22288.66816061873 26608.219565383555 24265.56038597732 0.9934029083704043 1.0338978938221517 0.9458191148315211 0.997234124753138 1.1442411617554662 1.0115884414453933 0.8308425749163384 0.9185309469918114 1.0965425542267724 1.0 14.566622557464669 -7.028128732656621 24.96901925285416 0.9499078690433811 1.023828333192095 0.1161227978064796 0.0784162291028733 1372.6246767843993 1218433.7082530723 0.030897571801281762 0.023991723796056533 9.372841379530101e-08 7.028128732656621 0.0739204641487139 MAPALSGANLTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 MAPALSGANLTSPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MAPALSGANLT(0.228)S(0.772)PR;MAPALS(0.001)GANLT(0.208)S(0.791)PR;MAPALSGANLT(0.025)S(0.975)PR 150.9 0.00041203 221435000.0 10670.2 11719.5 11692.1 11545.8 11560.3 9679.0 11558.900000000001 10493.6 5219.2 9367.1 True False 10918.794899405031 10347.375491752258 10104.377040108076 9529.54277150825 10514.672906136733 9581.638047828848 10687.002866876217 10215.275639983369 8856.601204714127 10569.458528280602 1.033051491728712 0.9789882295356835 0.955997605087516 0.9016112552984754 0.9948166103308623 0.9065401053603028 1.0111211315396245 0.966489968492752 0.8379427556309154 1.0 13.367613849120202 -4.835612989872626 2.0053206385542683 0.9465314006904818 1.0520448527381043 0.2192751390246096 0.05023861779650333 0.9998832953440128 4.876340484142385 0.013096621214036302 0.18917951899540883 1.4601148237051226e-05 4.835612989872626 0.10551345204762252 MAPALSGANLTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 MAPALSGANLTSPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MAPALS(0.003)GANLT(0.138)S(0.859)PR;MAPALSGANLT(0.092)S(0.908)PR;MAPALSGANLT(0.1)S(0.9)PR;MAPALS(0.001)GANLT(0.264)S(0.735)PR;MAPALS(0.007)GANLT(0.064)S(0.929)PR;MAPALSGANLT(0.079)S(0.921)PR 147.51 0.0004773 222650300.0 196928.0 202711.0 224664.0 232584.0 266245.0 178368.0 177762.0 171515.0 160747.0 202655.0 True False 185983.5301252446 218258.28188140207 210209.3628356678 200905.65797022096 232796.92283950045 202936.57293650808 186028.2852287206 172014.08025416304 192900.8916464487 196803.8235890758 0.945019902222917 1.1090144383430423 1.0681162540550158 1.020842249435711 1.1828882111842391 1.031161738809696 0.9452473119482964 0.8740383043234289 0.9801684140508552 1.0 17.586398724684145 -7.186698224500988 4.104655927469715 0.9388647614957989 1.0682954378488203 0.4062445878288762 0.0650234992114552 0.20480290910947158 6.608915445807009 0.02551948222322508 0.019137176270120907 6.505815988970133e-08 7.186698224500988 0.1294306763530214 MAPALSGANLTSPRVPLS(ph)AYER ddPTM_A459_Selumetinib_30min_R1 1 MAPALSGANLTSPRVPLSAYER 22 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MAPALS(0.001)GANLT(0.018)S(0.039)PRVPLS(0.741)AY(0.202)ER 54.008 0.015613 15264000.0 1283.0 1489.0 3399.4 3539.5 2041.4 1440.4 1149.1 985.06 813.85 1120.1 True False 1312.89140371658 1314.6671877826805 2937.780151567588 2921.392769643805 1856.7557304384438 1425.9108837785595 1062.422461854282 958.9330088741722 1381.0440087478144 1263.8757456979317 1.0387820228258127 1.0401870534011244 2.3244216542388827 2.311455678762604 1.4690967341992267 1.128204958938546 0.8406067332731318 0.7587241167798774 1.0927055238212364 1.0 10.303638920742861 -6.777946552210526 2.9660703054453297 0.9152366882561556 1.6958289729823721 0.40496151081298615 0.4156424005973879 0.2829843296513285 5.120582674348498 0.1724026925879212 0.1586968810982886 1.667452410096267e-07 6.777946552210526 0.7805922847262166 MAPPVDDLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 MAPPVDDLSPK 11 0 Q92576-2;Q92576;E7EVH3;E7ER40 Q92576-2 PHF3 PHD finger protein 3 1 MAPPVDDLS(1)PK;MAPPVDDLS(1)PK;MAPPVDDLS(1)PK;MAPPVDDLS(1)PK 158.58 0.00056126 160127000.0 24107.100000000002 29832.0 34880.7 37745.9 21536.9 25418.699999999997 25508.3 24264.800000000003 17571.8 25709.2 True False 24668.74852574902 26339.255571479443 30144.092525970333 31154.287143296544 19588.891197648518 25163.01095633302 23584.188394149856 23621.218680821512 29818.06120650591 29009.22624881463 0.8503759567443488 0.907961327391685 1.0391208737324413 1.073944091996234 0.6752641738746463 0.8674140682177356 0.8129892259747379 0.8142657262975678 1.0278819900521936 1.0 14.824224195185842 -4.758816500535623 22.092652308059225 0.9043600890502053 0.8503756532469287 0.019713792146610287 0.11901781467684884 105.41915928279873 887074.8422911036 0.030922553776281957 0.20084346639312572 1.742542982586416e-05 4.758816500535623 -0.05398443580327661 MAPPVDDLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 MAPPVDDLSPK 11 0 Q92576-2;Q92576;E7EVH3;E7ER40 Q92576-2 PHF3 PHD finger protein 3 1 MAPPVDDLS(1)PK;MAPPVDDLS(1)PK;MAPPVDDLS(1)PK;MAPPVDDLS(1)PK;MAPPVDDLS(1)PK;MAPPVDDLS(1)PK 166.62 0.00058431 134847700.0 817108.0 762246.0 653289.0 614337.0 554764.0 454336.0 630789.0 549593.0 383019.0 569406.0 True False 771696.4085024885 820707.8171928066 611257.0969872833 530663.2408095627 485069.5866669146 516916.65994842903 660121.9383846918 551192.2246399804 459633.5024450289 552965.7692855416 1.3955590949138812 1.4841928068227452 1.1054157977573493 0.9596674338362846 0.8772144924877499 0.9348077017792805 1.19378445294652 0.99679266829147 0.8312151094612918 1.0 19.076830649272004 -5.393944434492082 3.327787925238604 0.9761383304757969 1.4424850850723738 0.7957610137520118 0.0935389288277898 0.10896375759559021 2.2150502438433746 0.027068717254589928 0.06383040955150279 4.036970404029079e-06 5.393944434492082 0.46634675459657693 MAPS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 MAPSPTK 7 0 H3BMS0;Q15287-3;Q15287-2 H3BMS0 RNPS1 RNA-binding protein with serine-rich domain 1 1 MAPS(0.993)PT(0.007)K;MAPS(0.992)PT(0.008)K 88.177 0.03262 20652100.0 9273.8 10225.4 12103.6 12965.2 10951.7 11549.1 9355.6 10106.5 7834.5 9246.900000000001 True False 9489.861496326448 9028.205414340506 10459.997600315779 10701.071206946144 9961.12066867968 11432.926539743794 8649.899559763231 9838.442789461382 13294.574290759656 10433.829687433452 0.9095281196468136 0.8652820378325816 1.00250798735136 1.0256129846392412 0.9546945816718567 1.0957555262296124 0.8290244156640976 0.9429368778475312 1.2741797296894444 1.0 13.348981168947763 -1.9116282010606276 0.2955538005776413 1.0379678398496452 1.0566214319698185e-08 0.15935385101180355 0.11035669814488153 88.39923415890797 1.5540244844049897 0.11701826633682973 46.26393016826194 0.012256650404873354 1.9116282010606276 -1.037967829283431 MAPT(ph)PIPTR ddPTM_A459_Selumetinib_30min_R1 1 MAPTPIPTR 9 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 MAPT(1)PIPTR 121.61 0.014518 19610000.0 2116.7 3035.6 2779.7 3212.7 3058.8 2518.4 2701.5 2169.1 1713.7 2132.3 True False 2166.0149916187747 2680.1905407878467 2402.2320077991494 2651.662254848046 2782.132080075002 2493.0671825242453 2497.7236800098735 2111.568421770215 2908.0237363041474 2406.0014753608625 0.900255055452078 1.1139604726908408 0.9984333062135186 1.1021033370107713 1.1563301637866725 1.0361868885181478 1.0381222561948986 0.8776255723008287 1.2086541783470808 1.0 11.232421811837401 -4.747829702100168 24.723633859390272 1.0563453101747016 0.9002546122304628 0.225275857388337 0.08821341013421481 933.1889032850161 1695136.8478440058 0.02126875694768581 0.407653136021762 1.7871882393820035e-05 4.747829702100168 -0.1560906979442388 MAPT(ph)PIPTR ddPTM_A459_Selumetinib_30min_R2 1 MAPTPIPTR 9 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 MAPT(1)PIPTR 103.21 0.036108 16660000.0 68675.0 58024.0 72147.0 66372.0 78952.0 60371.0 58564.0 66577.0 49068.0 51494.0 True False 64858.31842780684 62474.254223433745 67505.14056771422 57332.019101913706 69033.34392016467 68686.55725662639 61287.342042364486 66770.72804758433 58882.97107447077 50007.234422520305 1.2969787107162736 1.2493043245618685 1.3499074953305934 1.1464745004193784 1.3804671407518614 1.3735324108564184 1.225569515093286 1.3352213698407351 1.1774890524230501 1.0 15.609849200646915 -8.575407757557764 3.338173226129546 1.0002167806048654 1.2928099606700698 0.6372754811295227 0.06884924457906226 0.16749672503647414 5.023497168391958 0.06442780474880629 0.01703987576135708 2.6582280868047107e-09 8.575407757557764 0.2925931800652044 MAPTPIPT(ph)RSPSDSSTASTPVAEQIER ddPTM_A459_Selumetinib_30min_R1 7 MAPTPIPTRSPSDSSTASTPVAEQIER 27 1 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 MAPTPIPT(0.975)RS(0.025)PSDSSTASTPVAEQIER;MAPT(0.009)PIPT(0.495)RS(0.495)PS(0.002)DSSTASTPVAEQIER;MAPT(0.004)PIPT(0.716)RS(0.263)PS(0.015)DSSTAST(0.001)PVAEQIER;MAPT(0.001)PIPT(0.71)RS(0.239)PS(0.045)DS(0.003)S(0.001)TASTPVAEQIER;MAPT(0.005)PIPT(0.42)RS(0.42)PS(0.111)DS(0.025)S(0.008)T(0.008)AS(0.001)T(0.003)PVAEQIER;MAPT(0.004)PIPT(0.346)RS(0.259)PS(0.196)DS(0.054)S(0.054)T(0.054)AS(0.008)T(0.025)PVAEQIER;MAPT(0.009)PIPT(0.863)RS(0.124)PS(0.004)DSSTASTPVAEQIER 152.66 5.0139999999999995e-14 717724300.0 8726.31 9987.95 12057.02 12385.850000000002 10911.050000000001 10280.83 9686.439999999999 8819.8 5487.99 7050.179999999999 True False 8929.616044556535 8818.55617072802 10419.742908470158 10222.89380869975 9924.14745400234 10177.414184446774 8955.784032202413 8585.870253252013 9312.718203069257 7955.13927756865 1.1224965060933183 1.1085357355834073 1.3098127568741664 1.2850678601599794 1.247513979043178 1.279350848469032 1.1257859504050811 1.0792859752263364 1.1706543252270407 1.0 12.957671473961165 -8.090542335616647 0.8822946963229256 1.0278828150975778 1.2248466638198952 0.4207682948831568 0.07448868077809867 0.5861595309591157 0.9050970331185471 0.07595775052442091 0.029001251964316646 8.118161081402378e-09 8.090542335616647 0.19696384872231731 MAPTPIPT(ph)RSPSDSSTASTPVAEQIER ddPTM_A459_Selumetinib_30min_R2 4 MAPTPIPTRSPSDSSTASTPVAEQIER 27 1 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 MAPT(0.008)PIPT(0.488)RS(0.488)PS(0.011)DS(0.001)S(0.002)T(0.002)AS(0.001)T(0.001)PVAEQIER;MAPT(0.005)PIPT(0.476)RS(0.476)PS(0.039)DS(0.002)S(0.001)T(0.001)ASTPVAEQIER;MAPT(0.001)PIPT(0.496)RS(0.496)PS(0.006)DSSTASTPVAEQIER;MAPTPIPT(0.836)RS(0.149)PS(0.008)DS(0.004)S(0.001)T(0.001)AST(0.001)PVAEQIER 124.7 1.0475e-11 185760000.0 203294.0 187041.0 218994.0 223316.0 234237.0 145996.0 123661.0 145097.0 106957.0 184823.0 True False 191995.73333036172 201386.44326839352 204904.16446263882 192899.97555841252 204810.05395465085 166105.62378026583 129411.48152962286 145519.20824789858 128351.38862827461 179486.67976217545 1.0696934924907022 1.1220133078133476 1.1416120947478787 1.0747314275020856 1.1410877633149688 0.9254481948206972 0.7210088330849758 0.8107521318056323 0.7151025847619643 1.0 17.453517255788135 -6.942414752364058 3.672151329189958 0.7971279601579306 1.1097601211452632 0.7677399155333784 0.07739580145275049 0.09731802582803022 2.69115773888066 0.027206439248841183 0.02319694482956478 1.1417874040000526e-07 6.942414752364058 0.3126321609873326 MAPTPIPTRS(ph)PSDSSTASTPVAEQIER ddPTM_A459_Selumetinib_30min_R1 2 MAPTPIPTRSPSDSSTASTPVAEQIER 27 1 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 MAPT(0.002)PIPT(0.2)RS(0.755)PS(0.023)DS(0.009)S(0.004)T(0.002)AS(0.002)T(0.002)PVAEQIER;MAPTPIPT(0.133)RS(0.863)PS(0.004)DSSTASTPVAEQIER 138.44 1.7812e-12 60027000.0 2228.28 2711.2 3002.9 3247.4 2858.55 3040.7 2662.02 2639.83 1521.26 2006.1599999999999 True False 2280.1945885218897 2393.7714435973157 2595.122673748987 2680.3025512477166 2599.9946572179915 3010.1133187347027 2461.2216881954027 2569.813133023681 2581.467111565646 2263.6701776532122 1.0072998315001034 1.057473596298813 1.1464226102229245 1.1840517128809085 1.1485748599265697 1.3297490723031664 1.0872704480062532 1.1352418556345751 1.1403901226643802 1.0 11.14444805390634 -5.141844450285936 2.5581898531050933 1.1581933949361367 1.010507407136917 0.2555543130663651 0.07823056782934806 0.3839924138959821 4.595882425660498 0.0206129894851606 0.08497460302539471 7.213658019493351e-06 5.141844450285936 -0.14768598779921982 MAPTPIPTRS(ph)PSDSSTASTPVAEQIER ddPTM_A459_Selumetinib_30min_R2 4 MAPTPIPTRSPSDSSTASTPVAEQIER 27 1 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 MAPT(0.001)PIPT(0.231)RS(0.742)PS(0.026)DSSTASTPVAEQIER;MAPTPIPT(0.006)RS(0.989)PS(0.004)DS(0.001)STASTPVAEQIER;MAPTPIPT(0.182)RS(0.813)PS(0.004)DSSTASTPVAEQIER;MAPTPIPT(0.145)RS(0.85)PS(0.005)DS(0.001)STASTPVAEQIER 120.42 4.397e-12 303528000.0 127677.0 124372.0 140264.0 137685.0 143199.0 108661.0 97185.0 80181.0 90451.0 130247.0 True False 120581.22347152686 133910.9324809887 131239.56694789638 118932.06548012703 125209.06140469726 123628.06642365173 101704.29506842424 80414.31343532082 108543.72741210065 126486.43068765287 0.9533135120975277 1.0586980101578642 1.037578230600727 0.9402752914565146 0.9899011358292656 0.977401811020665 0.8040727729883853 0.635754467875664 0.8581452320378923 1.0 16.9486230970666 -7.24973890321901 4.802315841157037 0.7926204889100814 0.9966931548797587 0.43776386206312057 0.09088672044358757 0.14946187290197552 9.981158034771353 0.03591707718242548 0.025946635069624774 5.626795050668152e-08 7.24973890321901 0.20407266596967732 MAPVPLDDSNRPAS(ph)LTK ddPTM_A459_Selumetinib_30min_R2 2 MAPVPLDDSNRPASLTK 17 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 MAPVPLDDSNRPAS(0.778)LT(0.222)K;MAPVPLDDS(0.002)NRPAS(0.682)LT(0.316)K 100.41 0.0024185 9170900.0 43269.0 35056.0 43769.0 53871.0 39358.0 31938.0 39822.0 32319.0 26855.0 36896.0 True False 40864.282199530775 37744.682477193805 40952.950192083976 46533.6768673416 34413.49617501573 36337.16959570214 41673.801905796005 32413.04293930154 32226.750391393805 35830.71661267933 1.1404818564267907 1.0534169016267227 1.1429564927426556 1.298709076080126 0.9604467738397927 1.0141346037953254 1.1630747538844644 0.9046160948908182 0.8994168534153683 1.0 15.128909277220904 -7.3203584934707155 0.860181709575393 0.9351491230714517 1.133605867859227 0.3560428311430873 0.09712953989384224 0.713748861978889 1.0154653104840141 0.08138076469856452 0.045864721286652865 4.782351645239328e-08 7.3203584934707155 0.1984567447877752 MAPYQGPDAVPGALDYK ddPTM_A459_Selumetinib_30min_R2 2 MAPYQGPDAVPGALDYK 17 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ; 236.4 3.1225e-21 11447200.0 83423.0 71340.0 83067.0 94846.0 84329.0 64837.0 66459.0 69294.0 59463.0 77097.0 False True 78786.68362872856 76811.54860574519 77722.55965651125 81927.81118152394 73734.83710917475 73767.7082183149 69549.47518601024 69495.63406776077 71357.26153503821 74871.00928793741 1.0522989389088149 1.0259184340676495 1.0380861750855714 1.0942527950497851 0.9848249383897952 0.9852639749334825 0.9289239700047087 0.9282048516335056 0.9530693149949923 1.0 16.192119582172914 -6.599686702827003 2.2997754072430543 0.9501658263130711 1.0491958086319872 0.7087388424105117 0.027828645542549317 0.15710771358691847 1.6888084741167582 0.010124234716167012 0.010355008957337451 2.513699143564017e-07 6.599686702827003 0.09902998231891613 MAS(ph)ALWTVLPSRMS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 MASALWTVLPSRMSLR 16 1 C9J6I7;E7EVF0;C9JRV6;C9J8U7;C9JD16;C9J0F8;C9JXR0;E7EVS2;A0A494C097;A0A494C0Y5;O75752 C9J6I7 B3GALNT1 UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 2 MAS(0.998)ALWT(0.002)VLPS(0.001)RMS(1)LR 103.67 0.031613 4650400.0 1950.3 2674.4 2273.6 2454.1 2185.1 2210.4 2258.7 2549.6 1373.6 2055.3 True False 1995.738195376811 2361.2800047051715 1964.8576079908428 2025.5375041624147 1987.4580908107387 2188.165382882621 2088.3244405101977 2481.976325732028 2330.898876225345 2319.1177753173474 0.8605592249853351 1.0181802881408446 0.8472435634373818 0.87340864087217 0.8569888566952041 0.943533530798449 0.9004822707740369 1.0702243552043815 1.0050799925011937 1.0 11.17936037310297 -7.749799100720681 24.990862961071358 1.028239125873244 0.9015593636317983 0.5589872262417681 0.050862757857875106 151.3018422934044 324836.11395039846 0.02404233152136916 0.013729910548475359 1.779102210489841e-08 7.749799100720681 -0.12667976224144561 MAS(ph)KLLR ddPTM_A459_Selumetinib_30min_R2 1 MASKLLR 7 1 P27144 P27144 AK4 Adenylate kinase 4, mitochondrial 1 MAS(1)KLLR 64.207 0.046323 2927900.0 33076.0 26757.0 35635.0 34193.0 33444.0 30665.0 32713.0 30704.0 29879.0 33143.0 True False 31237.76833371882 28809.17586268469 33342.282896454395 29535.854413784968 29242.465726846523 34888.8254008456 34234.21931957976 30793.343556679178 35855.634889013425 32186.075474144393 0.9705367266292729 0.8950819706437206 1.0359225971255428 0.9176593908602373 0.9085439991072376 1.083972646148561 1.0636344697283977 0.9567287438139509 1.1140107751818593 1.0 14.974149055800893 -6.759959149278814 24.999999939048184 1.0422126968388294 0.9462165538015598 0.4455549800623656 0.054713168315048466 38.345408940419595 647629.9388602201 0.018084475250809532 0.01716578461769035 1.73796429791363e-07 6.759959149278814 -0.09599614303726967 MAS(ph)NIFGTPEENQASWAK ddPTM_A459_Selumetinib_30min_R1 1 MASNIFGTPEENQASWAK 18 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 MAS(0.971)NIFGT(0.029)PEENQASWAK 105.65 0.0065122 14243000.0 1424.3 1987.1 2532.3 2081.2 1871.3 1544.3 1853.6 1628.2 1105.5 1519.8 True False 1457.483418794642 1754.4494082222734 2188.427568928224 1717.7574889624789 1702.0412454048483 1528.765744112212 1713.7814596580783 1585.0148468610316 1875.9527574746073 1714.8811341056319 0.8499034654986559 1.0230734791640692 1.2761395092666656 1.0016772910959495 0.9925126654871738 0.891470384569549 0.9993587459645551 0.9242709686042876 1.093925823875239 1.0 10.743892865037164 -5.983723325752648 24.99983366402496 0.9779047588287125 1.0623532574556722 0.06443803487543232 0.10832941095343476 574.6599616992994 882630.8732532911 0.03127677933056238 0.0463767946532357 1.0381896004800113e-06 5.983723325752648 0.08444849862695969 MAS(ph)NIFGTPEENQASWAK ddPTM_A459_Selumetinib_30min_R2 2 MASNIFGTPEENQASWAK 18 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 MAS(0.877)NIFGT(0.122)PEENQASWAK;MAS(0.552)NIFGT(0.448)PEENQASWAK 189.45 2.1884e-10 34682800.0 62306.0 67326.0 74647.0 73739.0 74807.0 58505.0 61216.0 61730.0 48359.0 70393.0 True False 58843.2819506798 72489.68771278941 69844.29328950858 63695.620993129916 65409.07587693477 66563.53269448786 64062.66529720276 61909.62408004837 58032.1512633556 68360.57118702121 0.8607780907753979 1.060402019088924 1.0217043549625733 0.9317596369824223 0.9568245955404362 0.9737123540466477 0.9371288768483192 0.9056335107364112 0.8489126152060803 1.0 16.060876831057946 -7.473016887418782 2.8009465918262113 0.908461087562688 0.9722375763108886 0.11169678198762512 0.06041109818260801 0.4894058374805079 7.607369800744581 0.030277394287940552 0.017549219762197234 3.3649848447216334e-08 7.473016887418782 0.06377648874820063 MAS(ph)PPAPSPAPPAISPIIK ddPTM_A459_Selumetinib_30min_R1 2 MASPPAPSPAPPAISPIIK 19 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 MAS(0.998)PPAPS(0.002)PAPPAISPIIK;MAS(0.995)PPAPS(0.005)PAPPAISPIIK 101.53 0.0011726 7557200.0 3545.6000000000004 5420.5 4941.7 4690.8 4082.3 3919.3999999999996 3761.7000000000003 3879.7 2101.6400000000003 3605.3500000000004 True False 3628.2055814633723 4785.865340077917 4270.644282815072 3871.6398372214076 3713.0566857886015 3879.974394530468 3477.9519404379553 3776.7977529583254 3566.329582287594 4068.1317915829327 0.8918603839163277 1.1764282931983652 1.0497802189327157 0.9516997077705123 0.912717895096469 0.9537484509617493 0.8549260738390839 0.9283862830532225 0.8766504540650378 1.0 11.9901507022998 -5.848592017097612 3.631787792935709 0.9169881638354953 1.053922454504396 0.33055892659468855 0.07430439992251736 0.22355845579613431 5.7323580798441895 0.020439244612743858 0.03251280233880262 1.4171244232808475e-06 5.848592017097612 0.13693429066890062 MAS(ph)PPAPSPAPPAISPIIK ddPTM_A459_Selumetinib_30min_R2 2 MASPPAPSPAPPAISPIIK 19 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 MAS(1)PPAPSPAPPAISPIIK;MAS(1)PPAPSPAPPAISPIIK 170.61 3.511000000000001e-09 8417600.0 72780.0 75473.0 85795.0 88441.0 93744.0 64603.0 81601.0 79382.0 73687.0 73993.0 True False 68735.17896142391 81261.53641605552 80275.04310653327 76395.18323076515 81967.04063800687 73501.47684235526 85395.60818931389 79612.98847760241 88426.45898680456 71856.62983309795 0.9565600157017625 1.1308843262591417 1.1171556931209945 1.0631612338097256 1.1407025465624046 1.0228906784673566 1.188416550952404 1.1079421434392376 1.2305956902264064 1.0 16.13283365225253 -4.757675375258881 24.970477497009806 1.11392236276382 0.9565597874454652 0.3278655987722916 0.06637388233099217 121.1510210610095 803600.3149973964 0.0154615648854644 0.11251409557354068 1.7471276010715703e-05 4.757675375258881 -0.15736257531835474 MAS(ph)VVIDDLPK ddPTM_A459_Selumetinib_30min_R1 1 MASVVIDDLPK 11 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 MAS(1)VVIDDLPK 137.16 0.0013561 1262600.0 831.29 1231.1 1072.1 1271.3 886.83 882.07 994.47 914.91 646.88 985.84 True False 850.6574395912369 1086.9622396771367 926.5147086237602 1049.2913202565815 806.6163830825528 873.1971766554801 919.4563272476096 890.6436147534862 1097.708113754115 1112.382166894785 0.764716897580125 0.977148206817619 0.8329104297043219 0.9432831193129231 0.7251252376098608 0.7849794815508505 0.8265651451553488 0.8006633342924923 0.9868084426581264 1.0 10.119436806143357 -8.271348425673223 23.33028593969836 0.9934043454393992 0.8352062395388402 0.44089766640901806 0.07266195564301366 296.80071673521263 698780.9723989635 0.06721174632403686 0.018309418357619952 5.353669710863208e-09 8.271348425673223 -0.15819810590055894 MASNIFGT(ph)PEENQASWAK ddPTM_A459_Selumetinib_30min_R1 3 MASNIFGTPEENQASWAK 18 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 MAS(0.063)NIFGT(0.937)PEENQASWAK;MASNIFGT(1)PEENQASWAK;MAS(0.094)NIFGT(0.906)PEENQASWAK 165.17 9.5887e-06 23355400.0 3431.9000000000005 4102.4 4100.1 4743.4 4234.73 3228.9599999999996 3738.9 3370.26 1881.78 2775.95 True False 3511.856592685063 3622.08910084598 3543.328940237181 3915.0542346456955 3851.6994192023058 3196.479594061107 3456.8717627943424 3280.869756652662 3193.243220226653 3132.270222542785 1.1211857033950694 1.1563782316027504 1.1312334787516185 1.2499094766694312 1.2296829920617405 1.0204993078362814 1.1036313974175718 1.047441479678354 1.0194660720026798 1.0 11.612992964693884 -6.768609300236753 24.997725302462623 1.045261711281225 1.1779272714523161 0.7027580608453912 0.045236463054860176 105.5258110812113 367910.52035571856 0.016873455297888855 0.015189306118342209 1.7036904922951927e-07 6.768609300236753 0.1326655601710911 MASNIFGT(ph)PEENQASWAK ddPTM_A459_Selumetinib_30min_R2 4 MASNIFGTPEENQASWAK 18 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 MASNIFGT(1)PEENQASWAK;MAS(0.004)NIFGT(0.984)PEENQAS(0.012)WAK;MAS(0.098)NIFGT(0.901)PEENQAS(0.001)WAK;MAS(0.003)NIFGT(0.95)PEENQAS(0.046)WAK 154.74 0.00015668 39318100.0 76015.7 87749.0 98792.0 103361.0 96123.0 76511.4 92393.0 73517.1 68328.0 94593.0 True False 71791.05170895728 94479.06614249409 92435.83027659688 89283.05349232958 84047.16938947707 87050.15084866324 96689.45757325631 73731.02258958892 81995.50924383375 91861.85430787012 0.781511022718455 1.0284907359463105 1.0062482514973312 0.9719274030012738 0.9149300329579398 0.9476202228285017 1.0525528610516257 0.8026293736950194 0.8925958425466806 1.0 16.487178285400574 -7.7655052098544415 24.999224351748346 0.8857094952453697 0.9607330051945207 0.08908153462802026 0.08343943992370137 206.89061256273033 1272054.3924677698 0.042069613192128624 0.02136770770440172 1.71591112569915e-08 7.7655052098544415 0.07502350994915097 MASNIFGTPEENQAS(ph)WAK ddPTM_A459_Selumetinib_30min_R1 1 MASNIFGTPEENQASWAK 18 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 MAS(0.006)NIFGT(0.133)PEENQAS(0.861)WAK 233.79 3.0735e-19 78011000.0 2931.0 3035.6 3857.1 4070.0 3309.1 2640.5 3326.0 2879.4 2215.4 2425.3 True False 2999.2865972667937 2680.1905407878467 3333.3270055337252 3359.2509033621395 3009.7924892690553 2613.9389673821756 3075.1171422220373 2803.0289583906497 3759.3719935859303 2736.610879422549 1.0959857756246558 0.9793831344240628 1.2180493144268612 1.2275223082029747 1.0998247912776515 0.9551737833965426 1.1236954312156051 1.024270194738872 1.3737327516505358 1.0 11.41817459615079 MATADTPAPAS(ph)S(ph)GLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 MATADTPAPASSGLSPK 17 0 O60293-2;O60293;G3V1X1;O60293-4 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 3 MAT(0.001)ADT(0.079)PAPAS(0.96)S(0.96)GLS(1)PK 74.96600000000002 0.016588 5761000.0 2542.2 1345.9 8144.6 9791.5 12067.0 7936.1 3156.2 5910.5 11799.0 6164.1 True False 2400.9147012329195 1449.1262022494059 7620.585303169992 8457.880808720369 10551.035579651265 9029.225738256991 3302.9695538916512 5927.698576464049 14159.12969160513 5986.126416744818 0.4010798526601293 0.24208078837022337 1.2730411576095602 1.4129138310646738 1.7625814834342888 1.5083586796629953 0.5517707652568696 0.9902394576704344 2.365324202308559 1.0 12.547407031069941 -5.2861149140303185 6.218375212525106 1.353520576062278 0.318134554349132 0.44605371428623686 0.46217347953646293 0.14872966153661923 21.98428333508413 0.12448105447862257 0.2772109611337819 5.174698916459359e-06 5.2861149140303185 -1.0353860217131459 MATFPGPGS(ph)SPAR ddPTM_A459_Selumetinib_30min_R2 1 MATFPGPGSSPAR 13 0 O43187 O43187 IRAK2 Interleukin-1 receptor-associated kinase-like 2 1 MATFPGPGS(0.905)S(0.095)PAR 98.0 0.012913 12980000.0 74700.0 67559.0 74105.0 67355.0 87462.0 58174.0 63090.0 55205.0 59627.0 69515.0 True False 70548.47304779293 72740.55806357642 69337.16497942327 58181.13280614413 76474.24163979947 66186.94044900664 66023.81001046323 55365.63741032027 71554.06611758095 67507.92132833913 1.045039925087686 1.0775114480238142 1.0270967260595572 0.861841568534866 1.1328187882996832 0.9804322092379705 0.9780157455795802 0.8201354199759421 1.0599358521137474 1.0 16.04276917638856 -7.140144889356277 3.5185597062119958 0.94929424078541 1.0241844243317775 0.09618585454572015 0.08623547967746895 0.5191604466768887 11.754388045085237 0.03461942825285188 0.026127949444164796 7.241943140091355e-08 7.140144889356277 0.07489018354636745 MATFPGPGSS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 1 MATFPGPGSSPAR 13 0 O43187 O43187 IRAK2 Interleukin-1 receptor-associated kinase-like 2 1 MATFPGPGS(0.155)S(0.845)PAR 133.88 0.0012783 10569000.0 3701.6 4294.7 5047.5 4983.9 3831.3 3579.8 3822.4 3125.8 2345.0 2924.5 True False 3787.8400779402127 3791.874527448139 4362.077223932873 4113.555424389818 3484.7595914709523 3543.790462198341 3534.073290568104 3042.893629970649 3979.2937279764396 3299.8880620423215 1.1478692630549094 1.1490918649832393 1.3218864221815922 1.2465742313222323 1.0560235759373646 1.0739123253790213 1.0709676280294318 0.9221202576451587 1.2058874886542756 1.0 11.688201371231527 -6.268271390649398 23.823961170529092 1.0526866860155955 1.2190888341230715 0.48899767390899285 0.08086063157937537 238.9651257691107 833295.9419119752 0.02477092601060804 0.02875301936424361 5.391735876102958e-07 6.268271390649398 0.166402148107476 MATFPGPGSS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 3 MATFPGPGSSPAR 13 0 O43187 O43187 IRAK2 Interleukin-1 receptor-associated kinase-like 2 1 MATFPGPGS(0.058)S(0.942)PAR;MAT(0.001)FPGPGS(0.05)S(0.949)PAR;MATFPGPGS(0.212)S(0.788)PAR 141.34 0.00083367 27976100.0 167012.0 166143.0 194399.0 168062.0 213103.0 165230.0 144110.0 147267.0 136331.0 178698.0 True False 157730.14164200771 178885.6338660546 181891.57998562764 145171.66567687923 186331.09597500833 187988.9326913981 150811.4005485475 147695.5225886356 163601.0094064089 173538.5244268369 0.908905628666366 1.0308122329429625 1.0481337246953044 0.8365385504823916 1.0737160327392592 1.0832691663841676 0.8690370109268097 0.8510820469198088 0.9427359714319941 1.0 17.404896441736057 -7.283377371788409 24.79730396004034 0.903303925752513 0.9969693984951509 0.18859692718068977 0.08087056205045956 1132.8124126682753 1280453.0398661552 0.03404580668493774 0.022975482807865728 5.207420257482093e-08 7.283377371788409 0.09366547274263792 MCS(ph)PSPDATSGTGSQR ddPTM_A459_Selumetinib_30min_R1 1 MCSPSPDATSGTGSQR 16 0 A0A2R8Y589;A0A2R8Y4C1;A0A2R8Y7U5;A8MST6;A0A2U3TZI9;A0A2R8Y5W6;A0A2R8Y432;A0A2R8YCP0;A0A2R8Y7A4;Q5JTW2;Q5JTW2-3;Q5JTW2-5;Q5JTW2-2 A0A2R8Y589 CEP78 Centrosomal protein of 78 kDa 1 MCS(0.748)PS(0.247)PDAT(0.004)S(0.001)GTGSQR 88.10799999999998 0.014202 3433500.0 842.19 895.21 1206.4 1359.6 801.16 735.61 1039.4 572.34 364.63 709.52 True False 861.8113883835291 790.3983970281619 1042.577506280855 1122.171382852866 728.695219456286 728.2104312804406 960.9972211742598 557.1596839776702 618.7504784784859 800.5938033100592 1.076465224712414 0.9872651946096205 1.3022552784824375 1.401673830365964 0.9101934294813323 0.9095878937229477 1.2003555575886447 0.6959330457893761 0.7728644362725002 1.0 9.644926638914558 -6.299966185387714 23.834370736572986 0.9136338517754625 1.1851785037731482 0.4067634594184023 0.16385108901635226 350.5244236914852 216848.57939066878 0.05453462739419601 0.06183808672784477 5.012262580968069e-07 6.299966185387714 0.2715446519976856 MCS(ph)PSPDATSGTGSQR ddPTM_A459_Selumetinib_30min_R2 2 MCSPSPDATSGTGSQR 16 0 A0A2R8Y589;A0A2R8Y4C1;A0A2R8Y7U5;A8MST6;A0A2U3TZI9;A0A2R8Y5W6;A0A2R8Y432;A0A2R8YCP0;A0A2R8Y7A4;Q5JTW2;Q5JTW2-3;Q5JTW2-5;Q5JTW2-2 A0A2R8Y589 CEP78 Centrosomal protein of 78 kDa 1 MCS(0.738)PS(0.261)PDATSGTGSQR;MCS(0.692)PS(0.308)PDATSGTGSQR 128.85 0.00091983 11767900.0 19902.2 18556.800000000003 17390.1 22469.0 20060.7 15280.5 25178.0 18578.5 15778.6 18775.4 True False 18796.115398819064 19980.046890483518 16271.239898909273 19408.683438813063 17540.49552106657 17385.2501724318 26348.826889260523 18632.56035916376 18934.760890919635 18233.305417652322 1.0308671394612776 1.095799496186803 0.8923911230684755 1.064463244279494 0.9620030553585188 0.9534886721965679 1.445093266728877 1.0218970138637016 1.038471108622368 1.0 14.154288503042904 MDAEHPELR ddPTM_A459_Selumetinib_30min_R2 1 MDAEHPELR 9 0 C9K052;Q12765-3;Q12765;Q12765-2 C9K052 SCRN1 Secernin-1 0 92.538 0.036193 2557600.0 40425.0 35589.0 38570.0 45436.0 44889.0 33792.0 35423.0 36278.0 29715.0 38214.0 False True 38178.34033409676 38318.561863328716 36088.44819184078 39247.5384185282 39249.64250724834 38446.54126676585 37070.239689342874 36383.56297385379 35658.83030647059 37110.66252810409 1.0287701089999166 1.0325485791128055 0.9724549693638807 1.0575811840816867 1.0576378817684644 1.035997167597051 0.9989107486633901 0.9804072602126231 0.9608782995848155 1.0 15.179546136916823 -7.476071449485223 3.06240985673379 0.9784607617170192 1.0305757405435816 0.4803793702716267 0.023829186854919696 0.23967890727865832 4.483600871067803 0.012544061932409119 0.007386660392563337 3.341400632753499e-08 7.476071449485223 0.05211497882656235 MDAPASGSACSGLNKQEPGGSHGS(ph)ETEDTGR ddPTM_A459_Selumetinib_30min_R1 1 MDAPASGSACSGLNKQEPGGSHGSETEDTGR 31 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 MDAPASGSACS(0.001)GLNKQEPGGS(0.032)HGS(0.955)ET(0.011)EDT(0.001)GR 103.12 4.639100000000001e-09 7347900.0 239.5 207.75 677.68 745.89 510.86 362.01 290.43 135.77 130.75 142.74 True False 245.07988401412396 183.4265334196453 585.6547782297829 615.6343135893824 464.6528031996585 358.36850807878136 268.52263127346544 132.1689385568863 221.87320039783336 161.06206940534136 1.5216486719622162 1.138856181948214 3.6362054727850195 3.822342006795089 2.8849300453868936 2.2250335501208744 1.6671996843507608 0.8206087196375185 1.3775633283305826 1.0 7.331472964862435 -7.330262669329037 2.2276746641435725 1.0829222835730234 2.6330153462568715 0.4189122697185569 0.7881693782339367 0.3532224254148304 3.4250858047765673 0.4543107825403691 0.28010971443272104 4.674523319621091e-08 7.330262669329037 1.550093062683848 MDCQECPEGYR ddPTM_A459_Selumetinib_30min_R2 3 MDCQECPEGYR 11 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ;; 183.85 0.00039447 33459200.0 59944.0 43887.8 58876.6 67295.0 64649.0 40679.4 48853.2 52508.0 43719.1 52332.9 False True 56612.55245484469 47253.8531384809 55088.543655995156 58129.304909649974 56527.214650606984 46282.618099173575 51124.9706007793 52660.78958683262 52464.1416137176 50821.91319979637 1.11393981238533 0.9297928819151624 1.0839525745405405 1.1437842704017465 1.1122606586725954 0.9106823255004697 1.0059631246031908 1.0361827462064852 1.0323133922067265 1.0 15.633163066469729 -6.73257543352313 24.99992685887012 0.9998480301977266 1.0727066760228654 0.2866757465582064 0.06263363603536165 332.4532007495929 287946.7841464179 0.022012738465392537 0.022009179478053545 1.851077348758291e-07 6.73257543352313 0.07285864582513879 MDENES(ph)NQS(ph)LMTSSQY(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 MDENESNQSLMTSSQYPK 18 0 C9JGB1;Q6IQ20 C9JGB1 NAPEPLD N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 3 MDENES(0.995)NQS(0.993)LMT(0.042)S(0.145)S(0.145)QY(0.679)PK 56.215 0.048221 0.0 5059.1 3944.5 3588.3 4174.6 5564.7 4016.3 4611.8 3401.8 3674.0 4255.1 True False 4777.935475181914 4247.03046643345 3357.432684645639 3606.0122784133246 4865.612636950807 4569.508868658607 4826.257838108333 3411.698674801695 4408.902660137067 4132.244206922483 1.1562568028234503 1.0277781887427353 0.8124961925099073 0.8726522678336398 1.1774746102371587 1.1058177203088828 1.1679507784228276 0.8256285214427298 1.0669511382582657 1.0 12.012709801620442 -4.785637962186607 5.022522264849171 1.0032284755043324 1.1628730589239573 0.11581009372139306 0.12538854647781975 0.37662714445335826 23.463224636120113 0.03341985849689068 0.19764885614381936 1.638181578009839e-05 4.785637962186607 0.15964458341962495 MDGEATS(ph)PLPR ddPTM_A459_Selumetinib_30min_R2 2 MDGEATSPLPR 11 0 Q86UU1-3;Q86UU1-2;Q86UU1;A0A087WZL0 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 MDGEAT(0.03)S(0.97)PLPR;MDGEAT(0.21)S(0.79)PLPR 121.29 0.0044846 27109000.0 181105.0 159593.0 194714.0 196670.0 199206.0 145087.0 170606.0 163600.0 157074.0 155170.0 True False 171039.90912075696 171833.2699276244 182186.313228574 169883.2067253267 174179.96135576456 165071.41728134645 178539.5170493755 164076.04891456192 188493.18901425405 150689.83891992216 1.1350460677819756 1.1403109271285243 1.209015249697024 1.1273700200555927 1.1558839176165372 1.0954382754969085 1.1848145722967618 1.088832864183718 1.2508686077660545 1.0 17.201222613110637 -10.648060136966096 4.575049355753462 0.9999864608966819 1.1518943332573692 0.48860546165478014 0.047267199688587835 6.700391345626289e-06 1.2811411684876192e-06 0.042100727523323264 0.010209911049257635 2.248743199721981e-11 10.648060136966096 0.15190787236068737 MDGTYACSYT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 MDGTYACSYTPVK 13 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 MDGTYACS(0.005)YT(0.994)PVK;MDGTYACSYT(1)PVK 134.68 0.0027991999999999995 3583600.0 35731.0 39236.0 40889.0 41256.0 46373.0 36525.0 46131.0 32290.0 38182.0 41589.0 True False 33745.21406252591 42245.275036375395 38258.2462565771 35636.8616294304 40547.20916011999 41555.98720906197 48276.18290684237 32383.958554102748 45819.46689421705 40388.217508801 0.8355212520872577 1.0459801804120157 0.9472625586469678 0.88235787136842 1.0039365850024045 1.028913623137899 1.1953036277553597 0.8018169790990642 1.1344760853640674 1.0 15.30164685517798 -6.458223794845786 6.305785349929823 1.0286229971276308 0.9376937687089307 0.17081042272667968 0.10797231417488619 0.4766685557998119 36.83303624326004 0.03280238951929981 0.036911423986853216 3.481578607331162e-07 6.458223794845786 -0.0909292284187001 MDGTYACSYTPVK ddPTM_A459_Selumetinib_30min_R2 1 MDGTYACSYTPVK 13 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 189.57 3.9536e-14 0.0 8326.8 9066.6 10717.0 8393.8 9541.3 8540.7 8187.1 8846.6 5831.4 9429.2 False True 7864.029790821438 9761.979066286098 10027.479887787342 7250.549959887353 8342.636593695755 9717.103900244641 8567.816372430878 8872.342141366531 6997.842942929583 9156.95449599621 0.858804070093382 1.0660726850345745 1.0950671309081814 0.7918080146688057 0.91107109873086 1.0611720200742891 0.9356622200292765 0.9689184482947772 0.7642107368764716 1.0 13.160652137995616 MDMT(ph)SPEQSR ddPTM_A459_Selumetinib_30min_R2 2 MDMTSPEQSR 10 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 MDMT(0.5)S(0.5)PEQSR;MDMT(0.5)S(0.5)PEQSR 135.1 0.0046823 18610000.0 128112.0 121700.0 138252.0 157011.0 156989.0 110958.0 117378.0 125451.0 120020.0 138204.0 True False 120992.04791296965 131033.99867282325 129357.01683739628 135625.83094091757 137266.63832053312 126241.457323562 122836.3095800946 125816.04164046902 144027.3536389905 134213.691422884 0.90148811667615 0.9763087303810004 0.9638138662754966 1.0105215757279498 1.0227469110288443 0.9406004408730337 0.9152293501343224 0.9374307517110497 1.0731196803550045 1.0 17.034172325858393 -4.759986100011532 5.949276170953582 0.9786102145848735 0.8984803006459529 0.2256960204618812 0.04442158574943196 0.23479683327646705 31.259281598500092 0.011459861020059449 0.07675002026731668 1.737856449529855e-05 4.759986100011532 -0.08012991393892066 MDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFS(ph)PTMGR ddPTM_A459_Selumetinib_30min_R1 2 MDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGR 38 2 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 MDRDPLGGLADMFGQMPGS(0.009)GIGT(0.244)GPGVIQDRFS(0.593)PT(0.154)MGR;MDRDPLGGLADMFGQMPGS(0.19)GIGT(0.09)GPGVIQDRFS(0.557)PT(0.162)MGR 71.44 4.2037e-05 58588000.0 2040.15 2161.63 2734.8 2751.6 2556.8 2184.69 2215.14 2112.4 1350.28 1646.81 True False 2087.681525559145 1908.5453546854758 2363.4291811811026 2271.0847139290577 2325.5378914397043 2162.71400213981 2048.050206380555 2056.3722899577715 2291.326539450756 1858.194104787798 1.1235002415409956 1.0270968731242571 1.2718957481844995 1.2221999349139099 1.2515042887326757 1.1638794873836862 1.1021723732217084 1.106650960015076 1.2330932132154304 1.0 10.859685496494734 -7.1131766304167705 5.501340115526298 1.1199372125765965 1.1809240095642726 0.12880572646676303 0.08345530293007927 0.5934190787315035 24.838512317212004 0.03373302396992745 0.026080059624341855 7.705900013118865e-08 7.1131766304167705 0.06098679698767606 MDRT(ph)PPPPT(ph)LSPAAITVGR ddPTM_A459_Selumetinib_30min_R1 3 MDRTPPPPTLSPAAITVGR 19 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 2 MDRT(1)PPPPT(0.583)LS(0.417)PAAITVGR;MDRT(1)PPPPT(0.983)LS(0.017)PAAITVGR;MDRT(1)PPPPT(0.86)LS(0.138)PAAIT(0.002)VGR 170.68 6.3855e-09 47614000.0 16744.3 18245.100000000002 17706.1 19603.9 21973.9 16362.0 20974.8 17757.8 8478.8 12540.9 True False 17134.409611263865 16108.955210083135 15301.708872645419 16180.44687577912 19986.36462480715 16197.413135507359 19392.653949091644 17286.80545853631 14387.904332949522 14150.646673710555 1.2108570022525278 1.138390038386781 1.0813434343656774 1.1434422220321268 1.4123993825623775 1.1446411961934815 1.3704429483862266 1.2216265346128805 1.0167665594873307 1.0 13.788580364171084 -8.27068078151671 7.736338092857512 1.0070846134319906 1.215427271101373 0.41386797089157157 0.09854999934234752 0.15752870332551983 71.98185456179814 0.08660395802433739 0.026009270000476942 5.361906276812105e-09 8.27068078151671 0.20834265766938231 MDRT(ph)PPPPT(ph)LSPAAITVGR ddPTM_A459_Selumetinib_30min_R2 6 MDRTPPPPTLSPAAITVGR 19 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 2 MDRT(1)PPPPT(0.587)LS(0.413)PAAITVGR;MDRT(1)PPPPT(0.986)LS(0.013)PAAIT(0.001)VGR;MDRT(1)PPPPT(0.881)LS(0.109)PAAIT(0.01)VGR;MDRT(1)PPPPT(0.539)LS(0.456)PAAIT(0.005)VGR;MDRT(1)PPPPT(0.726)LS(0.269)PAAIT(0.006)VGR;MDRT(1)PPPPT(0.584)LS(0.41)PAAIT(0.007)VGR 129.05 0.00058346 57989200.0 204862.0 186079.0 215919.0 230312.0 243636.0 182442.0 169212.0 172415.0 164495.0 195504.0 True False 193476.59016756288 200350.66096171126 202027.0066148321 198943.10828963944 213028.2675465249 207571.72945641857 177080.69328721685 172916.69910516034 197398.59637431815 189859.2915396051 1.0190525235748245 1.055258656750637 1.0640880674132758 1.047844994450216 1.1220323525861609 1.093292447123235 0.9326943751408522 0.9107623740873884 1.0397099598000994 1.0 17.534571079293706 -7.259685119799556 24.999546885693043 0.9633552065658852 1.0679059650263525 0.5576264701895608 0.04173338779771538 113.67496879051242 1619963.2116555467 0.01690317912501191 0.012407465255521732 5.4993945660055435e-08 7.259685119799556 0.10455075846046724 MDRT(ph)PPPPTLS(ph)PAAITVGR ddPTM_A459_Selumetinib_30min_R1 2 MDRTPPPPTLSPAAITVGR 19 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 2 MDRT(1)PPPPT(0.004)LS(0.996)PAAITVGR;MDRT(1)PPPPT(0.182)LS(0.817)PAAITVGR 153.52 3.9085e-05 27458000.0 11543.2 15008.3 14827.7 17317.8 15451.5 13573.2 14762.7 13335.7 7602.79 11160.6 True False 11812.13410084274 13251.121258830615 12814.179782725989 14293.571325367282 14053.914553183899 13436.66593147956 13649.13765348204 12981.993915541494 12901.379344188475 12593.17172345 0.9379792764079543 1.0522465308843074 1.0175498328879646 1.1350255232961632 1.1159948313111479 1.0669802831687647 1.0838522616241073 1.0308756364663447 1.0244741854956647 1.0 13.620354066371943 -4.289945550722906 1.514634834946471 1.0667615724134625 0.6472538999609283 0.4237455689805014 0.041592480035649096 4.213398969217748 3.257001569660183 0.012092305999718474 3.8257458298696467 5.1292568755352415e-05 4.289945550722906 -0.4195076724525342 MDRT(ph)PPPPTLS(ph)PAAITVGR ddPTM_A459_Selumetinib_30min_R2 3 MDRTPPPPTLSPAAITVGR 19 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 2 MDRT(1)PPPPT(0.182)LS(0.818)PAAITVGR;MDRT(1)PPPPT(0.026)LS(0.974)PAAITVGR;MDRT(1)PPPPT(0.345)LS(0.654)PAAIT(0.001)VGR 107.49 0.0026226999999999995 23005700.0 60154.0 58233.0 68915.0 75841.0 65987.0 56651.0 53413.0 56932.0 51605.0 66075.0 True False 56810.881495541296 62699.28385139281 64481.08392897877 65511.32496697767 57697.12312873526 64454.16102342424 55896.810335851595 57097.662694400016 61927.44196417344 64167.243066532676 0.8853564339149831 0.9771229190317902 1.0048909824927446 1.0209465427562685 0.8991678677687805 1.004471408512815 0.8711112970506498 0.8898257111529247 0.9650943223470445 1.0 15.969549378985429 -7.250252573482592 24.926601273183273 0.922326639076604 0.9671816689792271 0.07687059159495147 0.05353952122242637 1450.912568660862 3232949.271296388 0.020450871679819436 0.01569270263049119 5.620143783379929e-08 7.250252573482592 0.044855029902623134 MDRT(ph)PPPPTLSPAAITVGR ddPTM_A459_Selumetinib_30min_R1 4 MDRTPPPPTLSPAAITVGR 19 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR 141.91 0.00013462 55165600.0 5654.209999999999 6718.04 7109.0 7869.000000000001 7050.139999999999 6079.24 6559.799999999999 6115.99 4189.66 5383.4400000000005 True False 5785.942091822543 5931.488753667939 6143.63684694181 6494.826869424246 6412.456081803315 6018.088365108282 6064.989004674723 5953.7740776646615 7109.547019340623 6074.456963146219 0.9525035944654645 0.9764640345061839 1.011388653210535 1.0692028783524872 1.0556426888374943 0.9907203889368341 0.9984413489915333 0.9801327285362722 1.1704004263219419 1.0 12.568539726863094 -5.267190635645533 2.6441303981132944 1.0342794705881815 0.9580635552270235 0.23299175219525503 0.05265384042195836 0.4422833521964301 5.983199019792509 0.014294506019209272 0.04522286970796463 5.405170083312884e-06 5.267190635645533 -0.07621591536115802 MDRT(ph)PPPPTLSPAAITVGR ddPTM_A459_Selumetinib_30min_R2 6 MDRTPPPPTLSPAAITVGR 19 1 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR;MDRT(1)PPPPTLSPAAITVGR 112.57 0.00078474 135640900.0 75879.9 73121.2 88236.0 82622.7 79337.2 63921.5 64731.7 60163.4 47000.5 70216.2 True False 71662.7989293068 78729.36091828477 82558.99182409298 71369.34572789264 69370.15165243289 72726.10640339633 67741.85231343028 60338.46553341295 56401.91330369408 68188.8758624029 1.0509455981341276 1.1545777800641754 1.2107398865276395 1.046642063317007 1.0173235850436024 1.0665391602898548 0.993444333209501 0.8848725656538003 0.8271424420825837 1.0 16.057248780864192 -7.089042432708318 0.9234320445212002 0.8929932879075969 1.1248038641184914 0.6210752581623599 0.06590301575689089 0.3736608274760588 0.646647951532816 0.048556356034275466 0.0324980086159644 8.146246872911782e-08 7.089042432708318 0.23181057621089451 MDS(ph)DEDEKEGEEEK ddPTM_A459_Selumetinib_30min_R2 2 MDSDEDEKEGEEEK 14 1 Q96ST2;Q96ST2-3;Q96ST2-2 Q96ST2 IWS1 Protein IWS1 homolog 1 MDS(1)DEDEKEGEEEK;MDS(1)DEDEKEGEEEK 79.471 0.01978 190323000.0 282260.0 218990.0 193652.0 144100.0 136405.0 138062.0 240060.0 201713.0 120059.0 153868.0 True False 266573.11917630536 235785.82883616706 181192.64115235535 124473.3314136351 119268.58442382774 157078.78729794716 251223.26566986588 202299.95143461518 144074.15472874124 149425.4310429248 1.7839876205525418 1.5779497987088547 1.2125957401475047 0.8330130322855027 0.7981812974631203 1.0512185656859427 1.6812617766362543 1.3538522192818794 0.9641876467959036 1.0 17.18906617890415 -5.1928113610442646 2.853401598904791 1.1164254902383504 1.748137177001897 0.47350643970739903 0.24570325917484123 0.2787882593503633 4.335069310088841 0.07467822165862148 0.2575879435403039 6.4148815110792735e-06 5.1928113610442646 0.6317116867635466 MDS(ph)DEDEKEGEEEKVAK ddPTM_A459_Selumetinib_30min_R2 1 MDSDEDEKEGEEEKVAK 17 2 Q96ST2;Q96ST2-3;Q96ST2-2 Q96ST2 IWS1 Protein IWS1 homolog 1 MDS(1)DEDEKEGEEEKVAK 73.722 0.027657 32904000.0 191340.0 236260.0 154120.0 139960.0 106520.0 78258.0 80308.0 92027.0 42696.0 175600.0 True False 180706.08879470822 254380.38230436502 144204.08699316852 120897.2065555333 93138.0052991176 89037.329144607 84042.48112728306 92294.78333410999 51236.39302591511 170529.9717364076 1.0596734811756734 1.4917048288588652 0.8456231214068829 0.7089499008561797 0.5461679513035006 0.5221212918643663 0.49283114441131554 0.5412232371490234 0.3004538879834711 1.0 17.379665798879216 -5.573114249159233 2.2120398730784676 0.5490517270711178 1.2776046005954538 0.6454450355861425 0.1996861109667079 0.1666705107618944 1.624999919950265 0.05425681015297585 0.12522451069996335 2.6723033175995383e-06 5.573114249159233 0.728552873524336 MDS(ph)FDEDLAR ddPTM_A459_Selumetinib_30min_R1 2 MDSFDEDLAR 10 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 MDS(1)FDEDLAR;MDS(1)FDEDLAR 144.7 0.00095209 4615400.0 2719.0 3692.3 2813.0 3532.0 3219.5 2906.7 2910.7 3007.9 1631.55 2788.8 True False 2782.347409746986 3260.0037994962986 2431.010050702955 2915.2025038513693 2928.296793448893 2877.461237072437 2691.1435555819858 2928.1207209638224 2768.6211863027534 3146.7696452123873 0.884191638870088 1.0359842527578051 0.7725414710293728 0.9264111557344743 0.930572340401247 0.9144175015957441 0.8552083116971692 0.9305163869934917 0.8798296343410573 1.0 11.619655856729192 -10.933127597692193 5.938866395037311 1.0000300141979435 0.9045491029563433 0.17327638942256962 0.06331512379817766 2.3946820611097484e-05 2.3780101473878594e-06 0.058344688143542725 0.014146219574414772 1.1664668534487704e-11 10.933127597692193 -0.09548091124160019 MDS(ph)FDEDLAR ddPTM_A459_Selumetinib_30min_R2 2 MDSFDEDLAR 10 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 MDS(1)FDEDLAR;MDS(1)FDEDLAR 122.33 0.004499899999999999 2765800.0 38489.0 34178.0 46247.0 38854.0 40215.0 31246.0 34504.2 38259.0 31882.1 38184.0 True False 36349.93546367469 36799.342700408786 43271.51836992638 33562.018173111486 35162.83217333852 35549.85287705272 36108.71366877523 38370.32735588161 38259.410860303746 37081.52870605343 0.9802706827925539 0.9923901194073862 1.166929193047601 0.9050872319520258 0.9482573507709326 0.9586943720378316 0.9737655088335289 1.0347558122547893 1.0317646600707169 1.0 15.178413100621336 -11.053030159442564 11.312678549676574 1.0000000063156709 0.9986948347590057 0.0 0.06678610406929342 1.1009463648781402e-08 4.390520199790932e-10 0.06666366880398664 0.016168236279414265 8.850541453922301e-12 11.053030159442564 -0.0013051715566652078 MDS(ph)FDEDLARPSGLLAQER ddPTM_A459_Selumetinib_30min_R1 1 MDSFDEDLARPSGLLAQER 19 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 MDS(1)FDEDLARPSGLLAQER 61.985 0.01847 2833700.0 365.01 443.42 584.76 511.74 490.4 484.01 589.19 419.91 174.53 414.16 True False 373.5140228141772 391.50418025963484 505.3528038567579 422.37421554951896 446.0434065871523 479.1412988459183 544.7469239404097 408.77262274009104 296.1646628331464 467.3214702600266 0.7992657016300725 0.8377620228785859 1.0813815243189444 0.9038194100401633 0.9544680374710051 1.0252927146260045 1.1656792135771166 0.8747139790359774 0.6337493175059017 1.0 8.868271510577072 -12.212109217076103 2.149161142750449 3.076043910706553 0.9315151086309227 0.02159993058057663 0.14337060316545214 5221129.366317022 845099.4300762799 53167342.31536359 0.03841068482290284 6.136076747132081e-13 12.212109217076103 -2.1445288020756306 MDSNFGLAGLPGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 MDSNFGLAGLPGSPK 15 0 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 MDSNFGLAGLPGS(1)PK 132.87 0.0022247 9090900.0 1707.8 2099.4 2367.6 2304.8 1389.9 1449.0 1442.7 1514.8 1036.2 1509.3 True False 1747.5884171996702 1853.60127201542 2046.0929242958828 1902.3099464543147 1264.183790406776 1434.4243755867356 1333.875977475566 1474.6225832361456 1758.3557189463486 1703.033356826971 1.026162177149432 1.088411606610561 1.2014403100759505 1.1170127342653045 0.7423129942458419 0.842276147931302 0.783235379464789 0.8658800353644324 1.0324846027810355 1.0 10.733890977610166 -6.242952626095272 24.363425317958054 0.8644979566264119 1.1134952137601644 0.5990606693801783 0.09198466084917553 394.99963012812265 520563.87513539486 0.027736087459916684 0.03573372042066918 5.715409783599923e-07 6.242952626095272 0.24899725713375243 MDSNFGLAGLPGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 MDSNFGLAGLPGSPK 15 0 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 MDSNFGLAGLPGS(1)PK;MDSNFGLAGLPGS(1)PK 211.26 1.0076e-06 26776000.0 161929.0 150822.0 133505.0 156659.0 124811.0 120067.0 142050.0 126096.0 91276.0 147515.0 True False 152929.63443314654 162389.5624308339 124915.43364925345 135321.77394815118 109131.12635550294 136605.13939029284 148655.60646673493 126462.91848368348 109533.75046452665 143255.85866000102 1.0675279591608533 1.1335631502251102 0.8719743458850353 0.9446159843927895 0.7617917157197135 0.9535745390665468 1.037693032991757 0.8827765905464754 0.7646022402789866 1.0 17.12823461577078 -5.262112938281684 24.999962681235722 0.9011263258403172 1.1005455669974165 0.45815261856316625 0.08630670604729346 50.527225095030275 1875462.9894625389 0.022792264427981292 0.05240382928353225 5.468737298853731e-06 5.262112938281684 0.1994192411570993 MDSS(ph)LPEEEEDEDKEAINGSGNAENR ddPTM_A459_Selumetinib_30min_R2 1 MDSSLPEEEEDEDKEAINGSGNAENR 26 1 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 MDS(0.23)S(0.77)LPEEEEDEDKEAINGSGNAENR 71.794 0.011683 0.0 1470.8 1429.5 3266.4 2390.4 2609.0 2432.7 4146.3 2764.4 2558.0 3099.0 True False 1389.058824078899 1539.1380534330385 3056.243380187419 2064.8233963299967 2281.2340952440663 2767.7823431481183 4339.111165737581 2772.4439463289455 3069.6714764917297 3009.5238178310196 0.46155435482813406 0.5114224530518265 1.0155239051705098 0.6860963797980926 0.7580049979096575 0.9196745102163286 1.441793263116556 0.9212234606360621 1.0199857726010817 1.0 11.555319519155349 -6.86345689218597 3.286326124469117 1.0981785094054046 0.6911244590091833 0.5044626949599011 0.1907489202291805 0.21869560905006502 4.67346617243387 0.07387240481175125 0.06505313696843365 1.3694403114825903e-07 6.86345689218597 -0.40705405039622133 MDYEDDRLR ddPTM_A459_Selumetinib_30min_R2 2 MDYEDDRLR 9 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 0 ; 115.7 0.022781 75055000.0 139324.0 146680.0 142715.0 156136.0 153630.0 107483.0 109856.0 111103.0 103022.0 138281.0 False True 131580.92983816203 157929.88434946304 133532.87227634343 134870.00745037643 134329.62593037414 122287.807616471 114964.5216755344 111426.29133590826 123629.27867518776 134288.4682328145 0.9798378935266545 1.176049488297548 0.9943733369930089 1.0043305223837515 1.0003064872069898 0.9106352110924514 0.8561012214110717 0.8297532379528647 0.9206246843239955 1.0 17.034975895824367 -6.449305736549709 1.2376099488613466 0.8860284661503232 1.0611716830511033 0.4799293783913261 0.06635846674414998 0.34157284662601384 1.0855444113613804 0.02809372163947949 0.03394769765229855 3.553810477645385e-07 6.449305736549709 0.17514321690078016 MECADVPLLTPSSK ddPTM_A459_Selumetinib_30min_R1 1 MECADVPLLTPSSK 14 0 V9GYD6 V9GYD6 ETS1 0 136.99 0.0081808 32256000.0 3077.9 3810.8 3034.1 2874.2 3329.3 3756.9 3576.8 3295.3 1875.3 3255.2 False True 3149.6090814491536 3364.629764407143 2622.085885118321 2372.2749254160854 3028.1654028356575 3719.1089969922737 3306.9990963017995 3207.897939357054 3182.247133507128 3673.036628333101 0.8574946019197501 0.9160349065002601 0.7138741456842692 0.6458620388146448 0.8244310387424317 1.0125434002764304 0.9003447095496522 0.8733639938714316 0.8663804517929071 1.0 11.842757567677216 -6.538387540010347 22.38531890152745 0.9204768757123516 0.7812499628575034 0.4222983503130612 0.08197630133746643 78.47783668004959 113272.02757354955 0.029400857703069494 0.02941796306114388 2.89475931416907e-07 6.538387540010347 -0.13922691285484823 MEDEGGFPVPQENGQPES(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 MEDEGGFPVPQENGQPESPR 20 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 MEDEGGFPVPQENGQPES(1)PR;MEDEGGFPVPQENGQPES(1)PR 221.05 1.3252999999999998e-19 7129600.0 35740.0 29021.0 35190.0 42057.0 51836.0 34517.0 41390.0 39686.0 38410.0 41124.0 True False 33753.713878555776 31246.81738277734 32925.913711975045 36328.7640476283 45323.89826028036 39271.40343587109 43314.71701272907 39801.47968962902 46093.073265069324 39936.64326701607 0.8451815455014263 0.7824097076427123 0.8244537101386477 0.9096599282201681 1.1348950375534854 0.9833426202924169 1.0845858206741918 0.9966155498727485 1.1541549187519695 1.0 15.285425456809463 -6.0262207930660825 3.5804592646914024 1.055941824713092 0.8164160559137772 0.7926309953608817 0.05606712054420934 0.09532046462243596 2.579550019213944 0.01576744945911433 0.022414321214365596 9.414108664307717e-07 6.0262207930660825 -0.23952576879931486 MEDEGGFPVPQENGQPES(ph)PRR ddPTM_A459_Selumetinib_30min_R1 1 MEDEGGFPVPQENGQPESPRR 21 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 MEDEGGFPVPQENGQPES(1)PRR 75.17699999999998 0.0015804 2582200.0 526.67 645.02 527.04 720.11 807.04 702.79 696.75 588.0 318.94 602.21 True False 538.9403862785746 569.5007585383375 455.4708628234927 594.356306638848 734.0433744944842 695.7205706822642 644.1935865433569 572.4043299068211 541.2178855440533 679.5095195221427 0.7931314732096443 0.8381056367522746 0.670293571668867 0.8746842973691116 1.0802547328706915 1.0238569890404505 0.9480273168157801 0.8423786767687345 0.79648315438562 1.0 9.408349952204015 -5.9941415097163935 24.168878459743542 0.9473729394407003 0.7739728951931731 0.46623173169004584 0.08677465113194713 102.53746683763327 423002.5039884247 0.026746389336152407 0.03952790082654709 1.0135810685307164e-06 5.9941415097163935 -0.1734000442475272 MEDEGGFPVPQENGQPES(ph)PRR ddPTM_A459_Selumetinib_30min_R2 2 MEDEGGFPVPQENGQPESPRR 21 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 MEDEGGFPVPQENGQPES(1)PRR;MEDEGGFPVPQENGQPES(1)PRR 112.61 4.7693e-05 6658200.0 23765.0 21257.5 26495.0 31896.0 30261.0 22319.0 26992.0 24613.0 21465.0 27607.0 True False 22444.236438832628 22887.88189636431 24790.34054557484 27551.709776330983 26459.34264322757 25393.239658290317 28247.18148363334 24684.619755098487 25758.599782210706 26809.914178399787 0.837161815941787 0.8537096293581059 0.9246706416370375 1.0276687046812274 0.9869238098697584 0.9471585581855068 1.0536095451730887 0.9207272947925508 0.9607863572709194 1.0 14.71047898064556 -5.410412039755764 2.9747152959642436 0.9832087293482547 0.8431934949398264 0.6969762647836044 0.03661492317422186 0.14313044359874294 2.3937631437399363 0.010036292362926871 0.024341273131433524 3.886762108875335e-06 5.410412039755764 -0.14001523440842822 MEDLT(ph)NPEDIR ddPTM_A459_Selumetinib_30min_R2 1 MEDLTNPEDIR 11 0 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 1 MEDLT(1)NPEDIR 96.067 0.048172 6116300.0 31417.0 25329.0 31289.0 32487.0 38062.0 26266.0 25974.0 24238.0 25487.0 34449.0 True False 29670.968912215634 27271.652854428416 29275.899804887402 28062.214556799114 33280.311281402704 29883.9030809917 27181.842466504582 24308.528567183104 30585.11216628019 33454.3678607489 0.8869086702136667 0.815189602982321 0.8750994765988694 0.8388206488792678 0.9947971941938736 0.8932735840468136 0.8125050390922586 0.7266174829058313 0.9142337494938851 1.0 15.029906963500101 -12.25544707190023 1.4630493869027652 2.6556009494154407 0.859665212354525 0.27245416329327754 0.06759164188997316 1143658.3119568287 42062.9230581677 6261220.76219469 0.019881297299357042 5.553322921492895e-13 12.25544707190023 -1.7959357370609157 MEEDS(ph)IRLPAHLR ddPTM_A459_Selumetinib_30min_R1 1 MEEDSIRLPAHLR 13 1 P41212;H0YG25 P41212 ETV6 Transcription factor ETV6 1 MEEDS(1)IRLPAHLR 114.4 0.020126 15210000.0 1169.1 1248.8 1391.3 1491.6 1406.9 1057.0 1247.5 1247.8 728.87 855.19 True False 1196.3377553274001 1102.5899154486308 1202.3691018638533 1231.1200607997462 1279.6461434083694 1046.3675396792119 1153.4000706319887 1214.7042905743745 1236.839155441444 964.9619667560173 1.2397771068109715 1.1426252571956668 1.246027453191699 1.2758223673192963 1.3261104452751113 1.0843614315669472 1.1952803430268422 1.258810535981987 1.2817491238534675 1.0 9.914328270545282 -6.753354338380282 24.999886010522665 1.1821684448578074 1.2419756932695405 0.1642204690063782 0.08765263071253562 468.35967168930426 1448221.3965665123 0.029722555045436177 0.029222778089279273 1.7645975081948344e-07 6.753354338380282 0.05980724841173313 MEEEGTEDNGLEDDS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 MEEEGTEDNGLEDDSR 16 0 Q14151;K7ERX3 Q14151 SAFB2 Scaffold attachment factor B2 1 MEEEGT(0.001)EDNGLEDDS(0.999)R;MEEEGTEDNGLEDDS(1)R 294.85 3.996299999999999e-75 8059200.0 11385.900000000001 7867.799999999999 7831.1 13663.3 11858.900000000001 14029.599999999999 19327.4 24004.0 18110.2 7566.0 True False 10753.117259369004 8471.234961035645 7327.255551856995 11802.334969492835 10369.078962088866 15962.050051971411 20226.16239651656 24073.84766592388 21732.746041266804 7347.549921171179 1.4634969989635656 1.1529332977550364 0.9972379406017089 1.6062953087920735 1.411229467418993 2.1724316572492377 2.7527764511319663 3.2764456076110027 2.957822168536238 1.0 12.843047540618509 -6.876598898587017 2.301953521705724 2.6838096388017605 1.285270372409923 0.46063245451347745 0.5925351480896311 0.2299617594465076 2.4855295798821015 0.22995758365145372 0.19719025327210513 1.3286209659033296e-07 6.876598898587017 -1.3985392663918375 MEEEQHHWDDR ddPTM_A459_Selumetinib_30min_R1 4 MEEEQHHWDDR 11 0 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 ;;; 86.463 0.018061 42694800.0 10292.9 13224.300000000001 9337.8 9457.4 11189.400000000001 9822.3 12783.2 11051.3 6314.8 9725.7 False True 10532.704543503034 11675.992808189716 8069.778048863861 7805.842627385035 10177.320745649025 9723.49657993484 11818.952932186634 10758.183624318464 10715.75438525613 10974.088331340392 0.9597794573443672 1.063960162854238 0.735348377488247 0.7112975940874003 0.9273955556366432 0.8860413991899404 1.0769872243905156 0.9803259550585778 0.9764596440009966 1.0 13.421813472887758 -7.166364883929642 7.16907206980486 1.0065132535354107 0.8760268689208861 0.2840763638156705 0.09927322456899254 0.39301100034312714 25.72996743053773 0.04197623957108409 0.03245784717774638 6.817656501069968e-08 7.166364883929642 -0.13048638461452455 MEEEQHHWDDR ddPTM_A459_Selumetinib_30min_R2 2 MEEEQHHWDDR 11 0 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 ; 106.16 0.0063631 24641800.0 53934.0 43282.0 50344.0 51443.0 51986.0 46699.0 47239.0 57196.0 51827.0 48385.0 False True 50936.56419490844 46601.59022643496 47104.921850402716 44436.37465587519 45455.053919263344 53131.3633586854 49435.70710230272 57362.430890692456 62193.84816737175 46987.99933067243 1.0840334749400258 0.9917764299450554 1.00248834854422 0.9456962477410352 0.9673758101377936 1.1307432560552275 1.05209218963346 1.2207889611773255 1.3236113274304355 1.0 15.520004721087913 -7.288110837658358 1.4991318018532174 1.193560589174754 0.9994628501810324 0.38115189208747335 0.09065098717080437 0.37911687513808145 1.658500838874203 0.05284125097762667 0.030739718671382102 5.1509716823957624e-08 7.288110837658358 -0.19409773899372162 MEES(ph)DEEAVQAK ddPTM_A459_Selumetinib_30min_R2 2 MEESDEEAVQAK 12 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 MEES(1)DEEAVQAK;MEES(1)DEEAVQAK 179.83 0.00010392 16770200.0 73906.0 59959.0 67333.0 76524.0 75740.0 60087.0 62207.0 74236.0 61365.0 61066.0 True False 69798.60038915908 64557.66250142812 63000.86808662729 66101.29918873684 66224.86407580896 68363.43883452173 65099.74876083205 74452.01446956853 73639.71468135847 59302.86591147759 1.1769852825215674 1.0886094880775992 1.0623578998807541 1.114639202891263 1.1167228271001937 1.1527847395532118 1.0977504672035172 1.2554539030323482 1.2417564235644487 1.0 15.855814206687812 -7.72932498346287 24.999736437982463 1.1864540292474988 1.1140255138158797 0.07109331244025152 0.07186008377812099 315.27417139125725 245428.07187079272 0.03233741257932376 0.0186680711789632 1.8649835974503437e-08 7.72932498346287 -0.0724285154316191 MEGGGAEVHAQLPS(ph)LEGDLRGPDVK ddPTM_A459_Selumetinib_30min_R1 1 MEGGGAEVHAQLPSLEGDLRGPDVK 25 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MEGGGAEVHAQLPS(1)LEGDLRGPDVK 74.703 0.00013793 4411900.0 2375.2 2035.1 2701.5 3139.8 2505.1 2222.7 2301.6 2357.9 1615.1 1563.7 True False 2430.5375386653322 1796.8295459076783 2334.651138277297 2591.492871345564 2278.5141473113263 2200.3416560501273 2127.98845897121 2295.3608324613856 2740.706737763217 1764.4161267278434 1.377530788710727 1.0183706205632717 1.3231862387287117 1.4687537889100777 1.2913700531273715 1.247065033423107 1.206058155293344 1.3009180757819263 1.5533221989111663 1.0 10.784975136468718 -10.82317057384006 4.201390287873852 0.9996548313575861 1.3004543184211326 0.31024238159193696 0.13789104472964456 0.00045347191852499705 7.552219786003261e-05 0.1358031954417082 0.03289969300022218 1.502551706799841e-11 10.82317057384006 0.3007994870635464 MEGPGGSGFHLR ddPTM_A459_Selumetinib_30min_R1 2 MEGPGGSGFHLR 12 0 F8W870 F8W870 OLFM1 0 ; 68.786 0.036865 18999200.0 5558.9 6932.799999999999 6559.0 6792.8 6306.9 5765.299999999999 5912.3 5508.299999999999 3322.3 4757.0 False True 5688.4115542635245 6121.104553028717 5668.323826008061 5606.56499664824 5736.442008573636 5707.3063164735695 5466.330450979963 5362.201990519976 5637.700448808582 5367.60728710389 1.059766717272777 1.1403786129687927 1.0560243182519458 1.0445184784882577 1.0687149230078552 1.063286863438358 1.0183923969462638 0.9989929783803483 1.0503190988568805 1.0 12.390063407453324 -6.3664295447021635 0.3909777578836409 1.0041178129036588 1.1120221894692226 0.4973700417941046 0.02741927244318707 1.5237294041433795 0.42132314236276913 0.028005928093574033 0.0681901392689788 4.3010100296368156e-07 6.3664295447021635 0.10790437656556384 MEGS(ph)DFESSGGR ddPTM_A459_Selumetinib_30min_R1 2 MEGSDFESSGGR 12 0 E9PEN0;A0A1B0GW41;Q8WYH8-2;Q8WYH8 E9PEN0 ING5 Inhibitor of growth protein 5 1 MEGS(1)DFESSGGR;MEGS(1)DFESSGGR 169.09 0.00036182 22185500.0 5930.8 5472.0 5829.9 5634.799999999999 10026.3 4440.7 6201.9 5263.3 2590.6400000000003 3517.1 True False 6068.976100672094 4831.335696136214 5038.231601348439 4650.787958296063 9119.422935287037 4396.030589832996 5734.085689821662 5123.700186392134 4396.126867140673 3968.5540444551375 1.5292663354683718 1.2174045362659367 1.2695383620610772 1.1719099465948164 2.2979208127526176 1.1077159440414144 1.4448803331362778 1.291074816922543 1.1077402040884237 1.0 11.954397737148334 -8.205191518561847 1.4796850610399044 0.9997665236396064 1.4360937837754493 0.18882440891375618 0.3169526027354054 0.6995651117686523 2.855357380888197 0.2972585864502892 0.09247337849977806 6.2345983667856886e-09 8.205191518561847 0.4363272601358429 MEGS(ph)DFESSGGR ddPTM_A459_Selumetinib_30min_R2 1 MEGSDFESSGGR 12 0 E9PEN0;A0A1B0GW41;Q8WYH8-2;Q8WYH8 E9PEN0 ING5 Inhibitor of growth protein 5 1 MEGS(1)DFESSGGR 145.83 0.00067258 25260000.0 22393.0 24948.0 28142.0 28811.0 38680.0 23374.0 20151.0 20301.0 20047.0 22466.0 True False 21148.486706281466 26861.431379536498 26331.374358692858 24886.892098252836 33820.6725964126 26593.556331953867 21088.061428448993 20360.072548988534 24056.96015998032 21817.348206321927 0.969342676584011 1.2311959787923707 1.2069007704182362 1.1406928038597037 1.5501733884694804 1.2189179033338229 0.9665730788647535 0.9332056470129984 1.1026528032865806 1.0 14.413188139227518 -7.254322077043203 21.155401482452213 0.9950416551945661 1.2309379933488007 0.36865889573278476 0.13980299680367358 72.64677207738315 215936.33352337123 0.05613543544752066 0.042331800356673735 5.5677268770500935e-08 7.254322077043203 0.2358963381542346 MEIGDTLSTAEES(ph)SPPK ddPTM_A459_Selumetinib_30min_R2 1 MEIGDTLSTAEESSPPK 17 0 Q9BYW2;C9JG86;Q9BYW2-3;Q9BYW2-2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 MEIGDTLSTAEES(0.5)S(0.5)PPK 121.95 0.0053396 2846500.0 31755.0 29017.0 26945.0 30701.0 28348.0 21810.0 25747.0 26804.0 20135.0 24078.0 True False 29990.184225336856 31242.510595639364 25211.38803549779 26519.470837820987 24786.670805664566 24814.129528532267 26944.28651671261 26881.995202358925 24162.562618905788 23382.80557784293 1.282574245656601 1.3361318209498405 1.0782020126527325 1.1341440935962919 1.060038356951995 1.0612126695372104 1.1523119596155078 1.1496479801308255 1.0333474543277963 1.0 14.513160421070284 -5.263581232890502 24.996854275150664 1.091573875346549 1.3093530463579512 0.7701714466382467 0.04917249340250977 78.24284669279515 913158.5592313885 0.0125157244318047 0.02826758617236766 5.450279410525825e-06 5.263581232890502 0.21777917101140232 MEIGDTLSTAEESS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 4 MEIGDTLSTAEESSPPK 17 0 Q9BYW2;C9JG86;Q9BYW2-3;Q9BYW2-2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 MEIGDTLSTAEES(0.03)S(0.97)PPK;MEIGDTLSTAEES(0.016)S(0.984)PPK;MEIGDTLSTAEES(0.08)S(0.92)PPK;MEIGDTLSTAEES(0.093)S(0.907)PPK 264.92 8.477899999999998e-41 45999000.0 13078.2 16841.6 12822.400000000001 12895.8 11048.0 11966.199999999999 13141.3 13150.7 8443.48 14006.7 True False 13382.896614252686 14869.777642552566 11081.18850840155 10643.790614146801 10048.710350682817 11845.830892440297 12150.041160878669 12801.900716506181 14327.96887262025 15804.596381811656 0.8467724382796687 0.9408514639238175 0.701137076879361 0.6734617168962287 0.6358093625375423 0.7495180899445677 0.7687663048998363 0.8100112402262258 0.9065697425281453 1.0 13.948056571679299 -8.356525297180733 1.5493784626724967 0.9983999326750341 0.7548996802283985 0.483921061936488 0.0817964967135659 0.36188494065492854 1.7705293305796475 0.08794888199051756 0.02628646725410345 4.400223162686371e-09 8.356525297180733 -0.24350025244663565 MEIGDTLSTAEESS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 3 MEIGDTLSTAEESSPPK 17 0 Q9BYW2;C9JG86;Q9BYW2-3;Q9BYW2-2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 MEIGDTLSTAEES(0.184)S(0.816)PPK;MEIGDTLSTAEES(0.07)S(0.93)PPK;MEIGDTLSTAEES(0.159)S(0.841)PPK 285.04 2.8794999999999997e-64 20411300.0 135652.0 114310.0 115352.0 112765.0 104565.0 86109.0 125499.0 114439.0 82461.0 107662.0 True False 128113.00489798127 123077.20943541813 107930.37790576123 97406.21246952462 91428.60987703933 97969.7331303248 131334.9521715509 114771.9985436037 98955.50415284779 104553.51832053006 1.2253342303147066 1.1771694670101864 1.03229790483835 0.9316397385203823 0.874467080072297 0.9370295204220549 1.256150479498135 1.0977344463124312 0.946457907322445 1.0 16.673882085175173 -5.2283935777414925 3.430905385039189 1.01020882928383 1.2139328271707392 0.36979957380454753 0.10127792540058778 0.29007100664959556 7.092600106043949 0.03012278837138286 0.0887253985675396 5.910257765146509e-06 5.2283935777414925 0.2037239978869092 MEIQVPPS(ph)PTDVAK ddPTM_A459_Selumetinib_30min_R2 1 MEIQVPPSPTDVAK 14 0 Q5T5U3;A0A087WW76;A0A452Q6Z5;E7ESW5;A0A1B0GV73;Q5T5U3-3 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 MEIQVPPS(0.917)PT(0.083)DVAK 111.64 0.0048725 0.0 11208.0 13025.0 12552.0 9188.6 9018.3 9203.8 12375.0 12315.0 6820.1 11161.0 True False 10585.104229178878 14023.975618024002 11744.417985584281 7937.0968287808855 7885.340529375071 10471.539906222166 12950.462020597308 12350.834611141998 8184.310569515727 10838.752930239436 0.9765979810875757 1.2938735395377448 1.0835580496366972 0.7322887494406194 0.7275136337295289 0.9661203621504492 1.1948295254951644 1.1395069793208359 0.755097069025535 1.0 13.403911154243378 -5.536921325311479 24.894451145651136 0.9380725215735107 1.1486058148963434 0.20938288723424436 0.1679205534915724 336.73088403574843 596948.6783740405 0.049346430025034964 0.08552026613972946 2.904548780821356e-06 5.536921325311479 0.21053329332283266 MEISAELPQT(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 MEISAELPQTPQR 13 0 H3BS20;H3BNQ6;A0A087WTJ9;Q8IWV7-2;Q8IWV7 H3BS20 UBR1 E3 ubiquitin-protein ligase UBR1 1 MEISAELPQT(1)PQR;MEIS(0.003)AELPQT(0.997)PQR 134.4 0.0028665 22590000.0 2731.6000000000004 3777.1000000000004 3214.2 3104.1 3080.8 2749.7 3209.0 3234.1000000000004 1582.49 2526.7 True False 2795.240965231656 3334.87537607385 2777.7292943368057 2562.027206173568 2802.142183959417 2722.0405145278437 2966.9425464192764 3148.3211621626706 2685.369949503382 2851.0265571421896 0.9804331559905033 1.1697103864990512 0.97429092246729 0.8986332308113227 0.9828537643536461 0.9547580353851074 1.0406576322436218 1.1042763366324033 0.941895803382183 1.0 11.477265762618728 -5.318826125493079 24.999703830378472 0.988331259131046 1.075072777977533 0.21245415258268985 0.06766587580784471 375.5208782753289 163589.3675719099 0.01808064522489584 0.0376379268570191 4.799255535799329e-06 5.318826125493079 0.08674151884648706 MEISAELPQT(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 MEISAELPQTPQR 13 0 H3BS20;H3BNQ6;A0A087WTJ9;Q8IWV7-2;Q8IWV7 H3BS20 UBR1 E3 ubiquitin-protein ligase UBR1 1 MEISAELPQT(1)PQR;MEISAELPQT(1)PQR 118.52 0.0079682 9487400.0 38723.0 30748.0 37895.0 43423.0 41428.0 30910.0 28373.0 30727.0 28734.0 37196.0 True False 36570.930680450925 33106.27272959709 35456.87695695637 37508.7124911469 36223.44426898092 35167.57192695705 29692.4007200329 30816.410482871313 34481.60289504042 36122.05483318575 1.0124266420982448 0.9165113358717892 0.9815852702925894 1.0383881167437687 1.002806856815411 0.9735761735970843 0.8220019834739343 0.8531189774552892 0.9545858632428013 1.0 15.14059234361203 -7.078709769134539 9.199099843165309 0.8952837071823326 0.988409247842403 0.3328457833576046 0.05489021385107671 0.44914685300210677 49.824388600638336 0.021056692485177858 0.016318715932117565 8.342385043381674e-08 7.078709769134539 0.0931255406600704 MEITIRNS(ph)PYR ddPTM_A459_Selumetinib_30min_R1 1 MEITIRNSPYR 11 1 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;A0A087X1I0;Q9UQ88-9;A0A087WYI9 P21127 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 MEITIRNS(1)PYR 136.01 0.006884899999999999 27929000.0 3421.6 4426.4 4656.0 5144.1 4404.0 3699.7 4293.1 3272.8 1893.5 3010.3 True False 3501.3166227253705 3908.155030222466 4023.7407735773027 4245.779501716262 4005.6589775893526 3662.484377058829 3969.2680106053585 3185.9947124473547 3213.1312042317218 3396.7013278050936 1.0307990855904536 1.150573645739959 1.1846024672935829 1.2499713963546604 1.1792791273107783 1.0782474005229896 1.1685655073978054 0.9379672820707216 0.9459563541631749 1.0 11.729918652176195 -7.76098164650594 24.999928612228274 0.956471322002426 1.1526457806713282 0.6831055899383545 0.05847224337626989 7.047884914502999 385009.22447874973 0.031246983107585957 0.01660930959202674 1.733877270694742e-08 7.76098164650594 0.19617445866890215 MEITIRNS(ph)PYR ddPTM_A459_Selumetinib_30min_R2 1 MEITIRNSPYR 11 1 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;A0A087X1I0;Q9UQ88-9;A0A087WYI9 P21127 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 MEITIRNS(0.969)PY(0.031)R 65.809 0.043691 13429000.0 66366.0 76123.0 77774.0 78165.0 67694.0 52676.0 47146.0 47548.0 42490.0 68055.0 True False 62677.64340414762 81961.38932597631 72770.10551392843 67518.79215785404 59189.67452796166 59931.64085488152 49338.38241802669 47686.35680800488 50989.18726979421 66090.07532187474 0.9483669537202409 1.2401467077591366 1.101074634270279 1.0216177214055377 0.8955909679281427 0.9068175601707194 0.7465323980603255 0.721535821766895 0.7715105032255519 1.0 16.012146019528394 -6.374582213530359 1.3174674115017462 0.7958874741171278 1.1127805405885707 0.5820878578360952 0.10072432827266388 0.2729233927853041 0.9676751625859877 0.040154552992682294 0.05136992752413665 4.2210236596913476e-07 6.374582213530359 0.3168930664714429 MEPGEELEEEGS(ph)PGGR ddPTM_A459_Selumetinib_30min_R2 1 MEPGEELEEEGSPGGR 16 0 Q9H3H3-1;Q9H3H3;Q9H3H3-3 Q9H3H3-1 C11orf68 UPF0696 protein C11orf68 1 MEPGEELEEEGS(1)PGGR 157.37 0.00036366 0.0 5875.7 5149.4 6281.5 7070.6 5665.1 7150.8 7833.3 6334.4 6474.1 5937.3 True False 5549.152116290717 5544.342422069313 5877.355128780085 6107.572082534676 4953.399491363418 8135.757791500629 8197.563971389485 6352.832055283627 7769.100901467985 5765.874722041982 0.9624128833526732 0.9615787177744624 1.0193345176772453 1.0592620160799613 0.8590889899892195 1.411018827793635 1.4217381345542524 1.1017984887874521 1.347427975111565 1.0 12.493323775700206 -6.759328315525868 24.9999710381442 1.2730929355482639 0.9791781401561018 0.5354483889751156 0.13175907100384676 42.79135161686026 506751.344218296 0.04349686276184336 0.04146981973273685 1.7404906095170775e-07 6.759328315525868 -0.29391479539216203 MES(ph)HSEDEDLAGAVGGLGWNSR ddPTM_A459_Selumetinib_30min_R2 1 MESHSEDEDLAGAVGGLGWNSR 22 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7;K7EIM4 Q96MH2 HEXIM2 Protein HEXIM2 1 MES(0.5)HS(0.5)EDEDLAGAVGGLGWNSR 49.528 0.038544 2733100.0 28942.0 22304.0 26460.0 32026.0 25397.0 21117.0 22665.0 24351.0 22224.0 25910.0 True False 27333.519504005646 24014.645081336457 24757.59240746973 27664.003552068498 22206.401807939277 24025.675068959943 23718.967409845485 24421.857378474946 26669.42099044259 25161.910977735315 1.0863053894512182 0.9544046595898847 0.9839313249846822 1.099439687889651 0.8825403534568086 0.9548430200798033 0.9426536573805293 0.9705883388620519 1.0599123816168496 1.0 14.61895387463659 -4.752596557403153 24.848845762375067 0.9805917702819253 1.086305607856763 0.2222728248237782 0.05771190097777933 497.82860269630703 1398813.797638983 0.014458338553722888 0.16895135233246392 1.767679163039475e-05 4.752596557403153 0.10571383757483765 MESAECLEMTYVPNIDRIS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 3 MESAECLEMTYVPNIDRISPEK 22 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 MESAECLEMT(0.001)YVPNIDRIS(0.998)PEK;MESAECLEMTYVPNIDRIS(1)PEK;MESAECLEMT(0.005)Y(0.005)VPNIDRIS(0.99)PEK 86.508 0.00031857 53768000.0 1577.15 2167.1899999999996 2420.8199999999997 2535.58 2599.99 2257.07 2019.4 2016.29 1242.23 2022.47 True False 1613.894526400316 1913.4543873007012 2092.0859406124164 2092.7885517314435 2364.8213635655175 2234.365925055592 1867.0750321717323 1962.8114393670487 2107.973581110522 2282.0737250260654 0.707205253143994 0.8384717664101085 0.9167477446805629 0.91705562742393 1.0362598445580486 0.9790945404404371 0.8181484286404493 0.8600999248368411 0.9237096759818507 1.0 11.156129684970272 -4.810855171004522 1.737897315133972 0.9286714551702371 0.639408272031776 0.5736844286778354 0.06026866613701952 0.7072274824975665 2.265880268247469 0.01840058001271006 0.33743365398777186 1.5457698386002337e-05 4.810855171004522 -0.2892631831384611 MESAECLEMTYVPNIDRIS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 3 MESAECLEMTYVPNIDRISPEK 22 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 MESAECLEMTYVPNIDRIS(1)PEK;MESAECLEMT(0.027)Y(0.017)VPNIDRIS(0.955)PEK;MESAECLEMT(0.001)YVPNIDRIS(0.999)PEK 85.49600000000002 0.00034309 14105400.0 35347.3 33356.3 36960.3 30347.0 32379.9 23278.1 24986.4 31056.6 20585.0 29451.5 True False 33382.838572453125 35914.62095259073 34582.314537331964 26213.686248505037 28312.04748202122 26484.44697744736 26148.317109612304 31146.96956430311 24702.57519295632 28601.158670813267 1.16718483179912 1.2557051050257158 1.2091228518172696 0.916525325082561 0.9898916266952821 0.9259920999100656 0.9142397834496117 1.0890107608153572 0.8636914146476398 1.0 14.803785973223615 -5.754765445282653 24.985814094073916 0.9590494654098843 1.2151744390164056 0.782584717584081 0.061239408165738536 64.34570242076187 240893.84504899013 0.015852615068771184 0.0266739195201677 1.7588732936333689e-06 5.754765445282653 0.2561249736065213 MESAECLEMTYVPNIDRIS(ph)PEKK ddPTM_A459_Selumetinib_30min_R1 2 MESAECLEMTYVPNIDRISPEKK 23 2 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 MESAECLEMTYVPNIDRIS(1)PEKK;MESAECLEMT(0.011)Y(0.299)VPNIDRIS(0.69)PEKK 122.1 4.1163e-06 31081000.0 2538.31 3492.96 4037.14 3877.44 3175.56 3285.16 3226.83 3215.1400000000003 1687.79 2526.1 True False 2597.4476843085213 3084.002619366953 3488.9185624226566 3200.3178925632674 2888.331158690653 3252.114273086623 2983.427615164264 3129.8640429534303 2864.0563586956746 2850.349541297695 0.9112733882897627 1.0819734824392384 1.2240318290346373 1.122780854135609 1.0133252490063607 1.1409527940232953 1.0466883348650573 1.0980632366683278 1.0048088198304757 1.0 11.476923133965862 -8.26904570141691 21.798349113102187 1.0024042746437358 1.0849006688644796 0.13384706511892097 0.07801107001390914 218.36490126730652 625745.673851304 0.07068968400534326 0.019925992723846552 5.3821314261299344e-09 8.26904570141691 0.08249639422074373 MESEGGADDS(ph)AEEGDLLDDDDNEDRGDDQVK ddPTM_A459_Selumetinib_30min_R2 1 MESEGGADDSAEEGDLLDDDDNEDRGDDQVK 31 1 B4DY08 B4DY08 HNRNPC 1 MESEGGADDS(1)AEEGDLLDDDDNEDRGDDQVK 83.73299999999998 1.7925e-06 64121000.0 60459.0 47872.0 50960.0 64173.0 61868.0 56895.0 63194.0 63586.0 54804.0 54141.0 True False 57098.93081655302 51543.628467258764 47681.28908105283 55432.526695400345 54095.58873306248 64731.76980861275 66132.64621653549 63771.024732771046 65766.33135170152 52577.80865478836 1.0859891706679736 0.9803304813572635 0.9068709841848916 1.05429511258933 1.0288673133610313 1.231161424653964 1.2578052967316407 1.2128886000455879 1.250838196462417 1.0 15.682166393914112 -6.71080102122734 5.322676035839513 1.2082389016517312 1.0037312343398688 0.5375812467165015 0.08232334500403225 0.13564123998652075 8.312629527309372 0.026929531657988986 0.026410788249700834 1.9462515828175672e-07 6.71080102122734 -0.20450766731186243 MESHS(ph)EDEDLAGAVGGLGWNSR ddPTM_A459_Selumetinib_30min_R1 2 MESHSEDEDLAGAVGGLGWNSR 22 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7;K7EIM4 Q96MH2 HEXIM2 Protein HEXIM2 1 MES(0.478)HS(0.522)EDEDLAGAVGGLGWNSR;MES(0.03)HS(0.97)EDEDLAGAVGGLGWNSR 92.499 0.00020865 11721000.0 3210.3 3955.1 3518.59 3284.3 3520.8999999999996 3422.6 3670.5 3519.8 1659.63 3069.43 True False 3285.0937438435985 3492.035053323892 3040.784804231392 2710.758658946506 3202.4352166653835 3388.17175147216 3393.631229863498 3426.4434700782804 2816.270895420699 3463.4212392800696 0.9485111734564695 1.0082617192847643 0.8779714028847009 0.7826823454804426 0.9246450245050364 0.9782730766461571 0.9798494019078434 0.9893233405216757 0.8131470880527685 1.0 11.757982150932968 -6.527579537398912 24.349864154281725 0.9529927673574738 0.9028650316889192 0.08810113902526684 0.07259640499241635 258.98423194299374 1341505.5930256476 0.025324074381394883 0.025420981340890426 2.9677031836948897e-07 6.527579537398912 -0.05012773566855466 MESMNRPYTSLVPPLS(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 1 MESMNRPYTSLVPPLSPQPK 20 1 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 MESMNRPYTSLVPPLS(1)PQPK 82.859 0.0017266999999999998 32247000.0 2471.8 2304.5 2487.5 2720.1 2395.5 2376.0 2823.6 2733.9 1776.4 1790.6 True False 2529.3881307144543 2034.6880686670147 2149.711162859438 2245.0855976008256 2178.8274479598754 2352.0995972353926 2610.6135787065973 2661.388091041256 3014.4210568773346 2020.4409519210053 1.251899061098296 1.007051488801226 1.0639811872826694 1.1111859495157388 1.0783920440180539 1.1641516150219837 1.2921009031342712 1.3172313145359915 1.4919619670207476 1.0 10.980454473542748 -7.139942745794188 2.7085895218710685 1.3047016308960087 1.095974843762248 0.2791903755669999 0.12732881833072252 0.3066326275632865 4.3610139311520095 0.05223852191712226 0.03835402774635772 7.24531470705258e-08 7.139942745794188 -0.20872678713376058 MESMNRPYTSLVPPLS(ph)PQPK ddPTM_A459_Selumetinib_30min_R2 2 MESMNRPYTSLVPPLSPQPK 20 1 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 MESMNRPYTSLVPPLS(1)PQPK;MESMNRPY(0.003)T(0.003)S(0.003)LVPPLS(0.991)PQPK 86.006 0.0012833 13041600.0 60534.0 54103.0 58374.0 66081.0 67288.0 42588.0 55659.0 58269.0 45353.0 61750.0 True False 57169.76261680182 58252.52613143594 54618.28039280563 57080.653803916786 58834.6798776477 48454.110424627834 58247.25378621616 58438.553143047735 54424.86726869796 59967.117054232156 0.9533518605721781 0.9714078146987523 0.9108038384338333 0.9518658993110348 0.9811156975320271 0.8080113369600149 0.9713198940936145 0.9745099650229635 0.9075785187318247 1.0 15.871883995815898 -10.617407686911019 4.289032320993205 1.0000081077358005 0.9370273212346182 0.12888941348237293 0.049389709048731016 77026970444.64801 16261305431.630049 6542015.281844329 0.011820968749473536 2.413194423652247e-11 10.617407686911019 -0.06298078650118233 MESSFGS(ph)PSKQESSESLPK ddPTM_A459_Selumetinib_30min_R1 2 MESSFGSPSKQESSESLPK 19 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 MES(0.002)S(0.008)FGS(0.818)PS(0.122)KQES(0.022)S(0.022)ES(0.004)LPK;MES(0.026)S(0.06)FGS(0.757)PS(0.099)KQES(0.027)S(0.027)ES(0.005)LPK 63.691 0.015071 36719000.0 2903.35 2938.54 3433.1000000000004 3567.87 2721.02 3026.8199999999997 2946.4 2804.3 1746.7800000000002 2561.07 True False 2970.99240606433 2594.494370709815 2966.903876668439 2944.8084817146646 2474.9042214350993 2996.3729389326727 2724.1506758397527 2729.920854349828 2964.158080236539 2889.8082814343397 1.028093256272937 0.8978084765616536 1.026678446362481 1.019032473757403 0.8564250567538324 1.0368760302138245 0.9426752263605654 0.9446719603816927 1.0257282807582293 1.0 11.496758067838327 -8.269746752681675 24.459985968410816 1.0128641425312666 0.9678759496186893 0.08424625985497158 0.0577036273427494 1305.575887741288 3844035.594212909 0.04953429437798476 0.013703698157697095 5.373450435529928e-09 8.269746752681675 -0.044988192912577274 MESSFGS(ph)PSKQESSESLPK ddPTM_A459_Selumetinib_30min_R2 2 MESSFGSPSKQESSESLPK 19 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 MES(0.014)S(0.059)FGS(0.835)PS(0.023)KQES(0.048)S(0.016)ES(0.005)LPK;MES(0.002)S(0.009)FGS(0.955)PS(0.028)KQES(0.003)S(0.003)ES(0.001)LPK 81.346 0.0031804000000000003 115036000.0 45368.0 45058.0 46255.0 40397.0 41955.0 28631.0 39408.0 34507.0 25262.0 38789.0 True False 42846.628182493565 48513.803715694834 43279.00365863613 34894.85891128802 36684.23781754113 32574.660363659223 41240.55008547059 34607.40965705863 30315.105879254923 37669.06078407468 1.1374488052170337 1.2878952303532074 1.1489270705929882 0.9263533038774487 0.9738559192601397 0.8647590273190667 1.0948122737083432 0.9187223927730521 0.8047746678109696 1.0 15.20109244206093 -5.674904371707154 4.083376041257227 0.9412910195885723 1.2137458084838406 0.6725607890544523 0.08083929373185728 0.12206351467504525 3.802398019159205 0.022241884814155077 0.039641536878556746 2.1139544650500545e-06 5.674904371707154 0.2724547888952683 MESSFGSPS(ph)KQESSESLPK ddPTM_A459_Selumetinib_30min_R1 2 MESSFGSPSKQESSESLPK 19 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 MES(0.002)S(0.007)FGS(0.286)PS(0.427)KQES(0.122)S(0.122)ES(0.034)LPK;MES(0.002)S(0.007)FGS(0.013)PS(0.396)KQES(0.258)S(0.242)ES(0.082)LPK 64.346 0.014155 32714600.0 3104.5 3534.4 4195.1 4035.2 2965.8999999999996 3603.8 3168.2 3272.6 1513.1399999999999 3070.1 True False 3176.828809694562 3120.5908049020163 3625.4284620348253 3330.528070085236 2697.6348686721744 3567.549043988595 2929.220123267547 3185.8000170970467 2567.6880646269783 3464.177240306419 0.9170514639757751 0.9008173047825891 1.046548201937307 0.9614196500496142 0.778723108415076 1.0298402178963084 0.8455745535146021 0.9196411719439768 0.7412115161866998 1.0 11.75829703030687 MESTAGITTT(ph)TSPR ddPTM_A459_Selumetinib_30min_R2 1 MESTAGITTTTSPR 14 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 MESTAGIT(0.001)T(0.007)T(0.71)T(0.116)S(0.166)PR 137.62 0.0013690999999999998 3807200.0 20446.0 16716.0 19765.0 23636.0 25382.0 25659.0 26717.0 32944.0 28053.0 18130.0 True False 19309.693171822928 17998.06344958843 18493.341418504882 20416.73602562577 22193.286242040977 29193.29434078906 27959.39343873117 33039.8615858272 33664.38386631058 17606.539792602896 1.0967341339798968 1.0222373993753178 1.050367740416238 1.1596109324220272 1.2605137922310623 1.6580937926857242 1.588011827882152 1.8765675694953057 1.9120386096792354 1.0 14.103823784200653 -6.60303925372956 1.9315951591396228 1.6734371286214653 1.066608603113894 0.5110051449954829 0.23932371910556235 0.24084178379579163 1.8332806405750899 0.08805082842895769 0.09026709564103 2.4943692630569573e-07 6.60303925372956 -0.6068285255075714 MESTAGITTTTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 MESTAGITTTTSPR 14 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 MESTAGITTT(0.028)T(0.317)S(0.655)PR 137.84 0.00058372 5978800.0 18873.0 12014.0 18136.0 22278.0 23807.0 21303.0 24803.0 28788.0 26417.0 17043.0 True False 17824.114214605008 12935.43516890138 16969.14950498379 19243.697968306424 20816.151822719614 24237.294880620033 25956.388646212108 28871.768313890043 31701.138152651292 16550.924306968067 1.0769256075384817 0.7815536418987465 1.025268993456737 1.162696270697382 1.2577032821034564 1.4644073304362792 1.5682742646151955 1.7444202981301054 1.9153696533615872 1.0 14.014624167931979 -6.457657127217363 1.0982655489956015 1.6219745634152987 0.9342976149670807 0.5345146565894652 0.23435139440914796 0.34082745730685854 0.8694810561086134 0.10574077119548907 0.12972126767758052 3.4861243375991114e-07 6.457657127217363 -0.6876769484482179 METEADAPS(ph)PAPSLGER ddPTM_A459_Selumetinib_30min_R1 6 METEADAPSPAPSLGER 17 0 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 METEADAPS(1)PAPSLGER;METEADAPS(1)PAPSLGER;METEADAPS(1)PAPSLGER;METEADAPS(1)PAPSLGER;MET(0.001)EADAPS(0.999)PAPSLGER;METEADAPS(0.988)PAPS(0.012)LGER 308.25 5.431899999999998e-103 172162500.0 12741.0 13343.9 14864.5 15052.900000000001 16530.2 11528.23 13785.3 13290.5 6539.419999999999 11585.439999999999 True False 13037.840510329663 11781.589984589182 12845.982544853918 12424.19359292874 15035.046328643846 11412.266472995356 12745.463722391292 12937.99276637179 11096.91811966042 13072.544075742038 0.9973453089764851 0.9012469123322059 0.9826689028871941 0.9504036491247021 1.1501239729260895 0.8729950656026042 0.9749795945260809 0.9897073355736526 0.8488721135966432 1.0 13.674252313971898 -9.812812516406602 9.34795196032913 0.9999985713094681 0.9655045294002778 0.01838577627870719 0.07911165642403208 0.0 0.0 0.07409115825897378 0.017969745378006073 1.5388188002826227e-10 9.812812516406602 -0.034494041909190365 METEADAPS(ph)PAPSLGER ddPTM_A459_Selumetinib_30min_R2 7 METEADAPSPAPSLGER 17 0 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 METEADAPS(0.998)PAPS(0.002)LGER;METEADAPS(1)PAPSLGER;METEADAPS(1)PAPSLGER;METEADAPS(1)PAPSLGER;METEADAPS(1)PAPSLGER;MET(0.035)EADAPS(0.864)PAPS(0.102)LGER;METEADAPS(1)PAPSLGER 270.95 1.1815e-51 211587500.0 296536.0 242339.0 302526.0 337854.0 332645.0 221112.0 253694.0 290813.0 242032.0 258161.0 True False 280055.7162476617 260925.6220572986 283061.80652540346 291837.7023693426 290855.16121596855 251568.1709451094 265491.273685124 291659.2176833164 290445.1629391108 250707.2211471683 1.1170628231855573 1.040758303105007 1.1290532647212528 1.1640578242380588 1.1601387462439021 1.0034340845628682 1.058969392546046 1.1633458994470236 1.1585033794005313 1.0 17.9356440253082 METFS(ph)PAVGNR ddPTM_A459_Selumetinib_30min_R2 2 METFSPAVGNR 11 0 Q7Z4H7;Q5VY60;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 MET(0.044)FS(0.956)PAVGNR;MET(0.056)FS(0.944)PAVGNR 114.76 0.0063725000000000006 10232100.0 46944.0 44084.0 44451.0 47020.0 51908.0 49797.0 50564.0 37002.0 34848.0 47565.0 True False 44335.040411721384 47465.101047598466 41591.07105458945 40615.79488597578 45386.85297659216 56656.084737841455 52915.32619066521 37109.66969398915 41818.57373447372 46191.6748612883 0.9598058642570915 1.027568305114162 0.9004018836616278 0.8792882052435497 0.9825764732040354 1.2265432008684973 1.1455598081162408 0.8033843718684798 0.905327071600092 1.0 15.49534523728149 -4.4978060850110415 16.370228484648862 0.9863847622939708 0.891549429758246 0.004119281743112602 0.11992954359558267 23601869.05329245 440236481.89485085 0.03296369441834431 59021163.04295079 3.178292879959967e-05 4.4978060850110415 -0.09483533253572474 METNESTEGS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 METNESTEGSR 11 0 F2Z302;F8WBP3;C9JAA8;Q99932-1;Q99932;Q99932-2 F2Z302 SPAG8 Sperm-associated antigen 8 1 METNES(0.013)T(0.013)EGS(0.974)R 85.161 0.035264 7350100.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 METPKS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 METPKSR 7 1 A0A0C4DGF8;A0A1B0GV09;Q9H9B1-3;Q9H9B1;A0A0D9SER9;A0A1W2PPZ7;A0A1B0GVZ8;A0A1B0GUD1;A0A1B0GU48;Q9H9B1-4;A0A0D9SF38 A0A0C4DGF8 EHMT1 Histone-lysine N-methyltransferase EHMT1 1 METPKS(1)R 66.993 0.042065 42980000.0 226260.0 236290.0 244680.0 309080.0 339720.0 215610.0 221140.0 238000.0 235820.0 249620.0 True False 213685.3749905436 254412.68320790006 228937.55518744068 266982.7708072608 297041.3364646666 245308.32038729245 231423.44818059698 238692.54059697886 282990.589361329 242412.8220093514 0.8814936983089963 1.0495017594328644 0.9444119056483288 1.1013558135838277 1.2253532383415255 1.0119444935046766 0.9546666973402484 0.9846531161943693 1.167391175993208 1.0 17.887106484139096 -3.912387311776592 1.1922519881264566 1.0543677342303766 6.439845914186636e-18 0.24614750376491734 0.0871734213730824 16.28873499304235 4.1661097150149216 0.027443665190830323 34.935829845678455 0.00012235245509480908 3.912387311776592 -1.0543677342303766 METVSNASSSSNPS(ph)SPGR ddPTM_A459_Selumetinib_30min_R1 1 METVSNASSSSNPSSPGR 18 0 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 METVSNASSSSNPS(0.5)S(0.5)PGR 194.32 1.0315999999999998e-09 5182700.0 1726.3 2370.3 2012.3 2775.7 2241.6 2044.5 2073.9 1723.2 950.37 1477.4 True False 1766.5194312049355 2092.7841740774243 1739.040712772683 2290.976101342087 2038.8476757866233 2023.934186257475 1917.4640532935312 1677.4951382575425 1612.7084777215211 1667.038681094657 1.0596751300605423 1.255390290465967 1.0431915782726446 1.3742789098557227 1.2230356133355098 1.214089516464287 1.1502216925371118 1.0062724742271842 0.9674091525354048 1.0 10.70307186491683 -7.71417721912699 2.9561017108917604 0.9824208104077435 1.1996226259312808 0.5139048219750205 0.08891811943808121 0.2047351392020977 3.61062229321101 0.05101853436263033 0.024541768646122505 1.9311801147583888e-08 7.71417721912699 0.21720181552353723 METVSNASSSSNPS(ph)SPGR ddPTM_A459_Selumetinib_30min_R2 1 METVSNASSSSNPSSPGR 18 0 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 METVSNASSSSNPS(0.5)S(0.5)PGR 232.37 1.8606e-18 24697000.0 47229.0 39840.0 52560.0 45234.0 50520.0 43413.0 32856.0 45430.0 33485.0 46052.0 True False 44604.20125266682 42895.599894209314 49178.34682300107 39073.051166997604 44173.22594546963 49392.74668602348 34383.8691029289 45562.19377865861 40182.93564907173 44722.3591025344 0.9973579692073783 0.9591533352671111 1.0996366875515329 0.8736804576300482 0.9877212837586279 1.1044307070828114 0.7688295025782836 1.0187788545366925 0.8984976744394189 1.0 15.448708671839663 -7.234802164652591 24.999843407296698 0.9230913124957748 0.9993696666117808 0.17062441624986802 0.08838483357997864 1438.664957233826 1350233.2182267252 0.03249245235506993 0.02516072189135635 5.8236844523934616e-08 7.234802164652591 0.07627835411600603 METVSNASSSSNPSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 11 METVSNASSSSNPSSPGR 18 0 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 METVSNASSSSNPS(0.041)S(0.959)PGR;METVSNASSSSNPS(0.014)S(0.986)PGR;METVSNASSSSNPS(0.149)S(0.851)PGR;METVSNASSSSNPS(0.036)S(0.964)PGR;METVSNASSSSNPS(0.291)S(0.709)PGR;METVSNASSSSNPS(0.042)S(0.958)PGR;METVSNASSSSNPS(0.117)S(0.883)PGR;METVSNASSSSNPS(0.006)S(0.994)PGR;METVSNASSSSNPS(0.007)S(0.993)PGR;METVSNASSSSNPS(0.071)S(0.929)PGR;METVSNASSSSNPS(0.023)S(0.977)PGR 362.14 3.294899999999997e-206 378277000.0 26551.559999999998 38958.2 39237.6 44903.299999999996 37587.0 33493.3 34979.3 29945.010000000002 15060.3 24567.840000000004 True False 27170.15968765786 34396.95583282417 33909.34943670893 37061.78159433443 34187.26248652383 33156.38781148322 32340.783239004013 29150.771059699095 25556.229139208353 27721.36157502676 0.9801163486909871 1.2408104753343439 1.2232209209830702 1.3369394390686113 1.2332461518528723 1.1960591373460059 1.1666376181225793 1.051563465986463 0.9218966056209554 1.0 14.758710498831844 -7.837988717414981 2.17122079806478 0.9610927883717963 1.2111958814265873 0.5567780495027583 0.08647782374895184 0.2363055504322931 2.163627169911787 0.06431333070797808 0.02520338846595855 1.4521493426482311e-08 7.837988717414981 0.25010309305479095 METVSNASSSSNPSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 13 METVSNASSSSNPSSPGR 18 0 Q9NTI5-2;Q9NTI5;A9IYQ1 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 METVSNASSSSNPS(0.059)S(0.941)PGR;METVSNASSSSNPS(0.23)S(0.77)PGR;METVSNASSSSNPS(0.097)S(0.903)PGR;METVSNASSSSNPS(0.402)S(0.597)PGR;METVSNASSSSNPS(0.046)S(0.953)PGR;METVSNASSSSNPS(0.071)S(0.929)PGR;METVSNASSSSNPS(0.043)S(0.957)PGR;METVSNASSS(0.001)SNPS(0.374)S(0.624)PGR;METVSNASSSSNPS(0.011)S(0.989)PGR;METVSNASSSSNPS(0.027)S(0.973)PGR;METVSNASSSSNPS(0.019)S(0.981)PGR;METVSNASSSSNPS(0.078)S(0.922)PGR;METVSNASSSSNPS(0.092)S(0.908)PGR 390.62 1.5998999999999982e-283 361008400.0 444042.6 433758.4 530355.4 520703.9 573842.4 404787.1 401591.6 463702.9 381971.0 474540.1 True False 419364.4899353664 467026.2745269185 496232.9109712985 449783.1305556719 501751.1874958543 460542.8487335599 420266.4051386588 465052.19866885216 458375.87316146295 460838.89430975006 0.9100023785177583 1.0134263411651396 1.0768034493151062 0.9760094820758616 1.0887778650875013 0.9993575942051645 0.9119594945824588 1.0091426839425366 0.9946553531424984 1.0 18.813902958273907 -9.368247432160505 12.181525774229826 1.0000000432020648 1.0004670834257645 0.0 0.05524480145347368 0.0 0.0 0.05425561117927819 0.013158918569094494 4.283044314437357e-10 9.368247432160505 0.00046704022369969955 MEVDRS(ph)PGLPMSDLK ddPTM_A459_Selumetinib_30min_R1 4 MEVDRSPGLPMSDLK 15 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 MEVDRS(1)PGLPMSDLK;MEVDRS(1)PGLPMSDLK;MEVDRS(1)PGLPMSDLK;MEVDRS(1)PGLPMSDLK 152.34 0.0019425 358289200.0 13357.9 16164.800000000001 18271.3 19654.0 18238.3 16016.3 17036.6 14048.400000000001 9326.39 12616.3 True False 13669.113080051213 14272.217701188369 15790.15781706679 16221.797851272604 16588.648985233387 15855.190563636872 15751.515545754652 13675.790796365629 15826.202657425241 14235.724998168755 0.960197888186908 1.0025634593969965 1.10919238880338 1.1395132916208575 1.1652830458137753 1.113760666609986 1.106477931245573 0.9606669697626813 1.111724387726026 1.0 13.797228348191842 -5.121229317530992 3.7366177101395346 1.0929250056495023 0.967803418064195 0.3496254508367589 0.05915121075061131 0.2592587298335796 6.273784613852617 0.01617793708868892 0.05255024623865059 7.564333752351766e-06 5.121229317530992 -0.12512158758530734 MEVDRS(ph)PGLPMSDLK ddPTM_A459_Selumetinib_30min_R2 4 MEVDRSPGLPMSDLK 15 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 MEVDRS(1)PGLPMSDLK;MEVDRS(1)PGLPMSDLK;MEVDRS(1)PGLPMSDLK;MEVDRS(1)PGLPMSDLK 111.73 0.0017505 154686400.0 188904.0 192247.0 227014.0 216656.0 212957.0 168419.0 171814.0 177059.0 159722.0 235330.0 True False 178405.47192262748 206991.72672846576 212408.16639415416 187147.07904755394 186203.4378002646 191617.18849453836 179803.69144298238 177574.2123763048 191670.86300555588 228535.41143923023 0.7806469500682489 0.9057315250398595 0.9294321832073519 0.8188975085697743 0.8147684274731222 0.8384573195366322 0.7867651245408588 0.777009616400404 0.8386921825308592 1.0 17.80205820186257 -4.707182342028759 23.02916705348472 0.846705978343416 0.7806433492660105 0.08882969563174647 0.06648516141424225 23765.895874655685 10084694.898539534 0.016640440868380183 20.848248055409474 1.9625361172709235e-05 4.707182342028759 -0.06606262907740545 MEVEELS(ph)PLALGR ddPTM_A459_Selumetinib_30min_R1 2 MEVEELSPLALGR 13 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 MEVEELS(1)PLALGR;MEVEELS(1)PLALGR 175.88 9.969e-05 13550700.0 3032.1000000000004 3553.0 3053.1 2907.9 3230.8 2575.8 3612.7 3421.3 1677.8899999999999 2619.9 True False 3102.7420305604414 3137.013108255113 2638.5057894778506 2400.089853043432 2938.5747104440684 2549.8897906392763 3340.191130398544 3330.5560100513744 2847.256781763064 2956.1896849870654 1.0495747435686007 1.0611677336492833 0.8925360246256983 0.8118862822748579 0.9940413246712637 0.8625595994698266 1.129897430926581 1.1266381271017618 0.9631509088279366 1.0 11.529523128168584 -7.26644687966135 24.984913338931594 1.0654747918432128 0.9443149314536446 0.2700174661182615 0.08761142740593514 573.3784412239901 2860855.9114734186 0.03788501986106685 0.026440783447476635 5.414434700033402e-08 7.26644687966135 -0.12115986038956816 MEVEELS(ph)PLALGR ddPTM_A459_Selumetinib_30min_R2 1 MEVEELSPLALGR 13 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 MEVEELS(1)PLALGR 129.76 0.0016929000000000002 1550400.0 8198.0 8961.1 9698.9 10225.0 10570.0 8535.6 9050.7 8709.1 9262.5 10131.0 True False 7742.387979194192 9648.387555522064 9074.883333363876 8832.337360891155 9242.10210300107 9711.301421537828 9471.575483621822 8734.442039130876 11115.258815873594 9838.491706500825 0.7869486716219293 0.9806775106744107 0.9223856261796316 0.8977328664164194 0.9393820088189242 0.9870721764313777 0.962706049481491 0.887782629664622 1.1297726468101956 1.0 13.264221444297766 -1.52287874528067 0.2054273771692512 1.020797546404761 0.21207823531947495 0.3730974014852776 0.0668828917334888 63.81447583831157 0.7839174811925437 0.11447465091422546 16.746102192297496 0.029999999999977035 1.52287874528067 -0.8087193110852859 MEVGPFST(ph)GQESPTAENAR ddPTM_A459_Selumetinib_30min_R1 1 MEVGPFSTGQESPTAENAR 19 0 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 MEVGPFS(0.003)T(0.836)GQES(0.106)PT(0.055)AENAR 202.03 3.3658999999999997e-15 10854000.0 2115.4 1472.4 960.83 812.75 1626.2 1192.0 1799.7 2095.8 1020.3 1845.4 True False 2164.6847041481324 1300.0107234998115 830.354563461401 670.8184697070216 1479.110497128929 1180.0095622494055 1663.9471800532178 2040.2125758821703 1731.3745802364012 2082.2750657182078 1.039576730176856 0.6243222833057449 0.39877275444154603 0.32215651080451574 0.7103338658184247 0.5666924517690474 0.799100564304792 0.979799743785757 0.8314821652245181 1.0 11.023944943950559 -7.440184469307985 3.0485823648038615 0.9284920078884938 0.5921297264002771 0.38458157156220474 0.1857105419515221 0.2912439575889924 5.242812656170569 0.09550756119267785 0.057724031046550404 3.629238678349391e-08 7.440184469307985 -0.3363622814882168 MEVGPFSTGQES(ph)PTAENAR ddPTM_A459_Selumetinib_30min_R2 3 MEVGPFSTGQESPTAENAR 19 0 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 MEVGPFS(0.002)T(0.041)GQES(0.664)PT(0.293)AENAR;MEVGPFS(0.018)T(0.49)GQES(0.49)PT(0.002)AENAR;MEVGPFS(0.002)T(0.002)GQES(0.894)PT(0.103)AENAR 183.39 2.0548000000000002e-13 15924500.0 48842.7 34071.1 45206.0 57749.1 59040.0 48370.0 74476.0 77421.0 68598.0 39232.4 True False 46128.21826681971 36684.243814146444 42297.49517657132 49883.57295724595 51622.8673757032 55032.52844085766 77939.28157139428 77646.28229226344 82319.5167882643 38099.65867398314 1.2107252367150203 0.9628496708606151 1.110180422835513 1.3092918596488534 1.3549430407615322 1.4444362589116149 2.0456687614531353 2.0379784227643287 2.160636595006487 1.0 15.217490452555248 -6.88191380378219 1.7094495141293302 1.8937934592446442 1.1424657216921128 0.44382968287371993 0.3203407716584588 0.28727569910101786 1.7243298078307878 0.1378580203639346 0.11454438399333078 1.312460362594348e-07 6.88191380378219 -0.7513277375525313 MEVGPFSTGQESPT(ph)AENAR ddPTM_A459_Selumetinib_30min_R1 1 MEVGPFSTGQESPTAENAR 19 0 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 MEVGPFST(0.001)GQES(0.462)PT(0.537)AENAR 230.27 2.7274e-23 11791000.0 1012.5 767.68 634.04 587.64 804.77 684.2 925.95 1353.0 554.29 1361.2 True False 1036.0892800179565 677.7996687152502 547.9408505324212 485.0197053689747 731.9786955936831 677.3175692038953 856.1048460133778 1317.1140448366139 940.589646260154 1535.9232792108069 0.6745709854403166 0.44129786812237093 0.35675014367512287 0.3157838102552812 0.47657243398888444 0.44098398557505875 0.5573877664340529 0.8575389556654013 0.6123936390517181 1.0 10.584890438568515 -8.038868116757605 0.7870338930857904 0.9533101132919826 0.4282456035799112 0.6441276969811275 0.12404786665462415 0.37267186211768544 0.46549414920864574 0.11763715833428046 0.04864342525420308 9.14390874573768e-09 8.038868116757605 -0.5250645097120714 MEVGPFSTGQESPT(ph)AENAR ddPTM_A459_Selumetinib_30min_R2 3 MEVGPFSTGQESPTAENAR 19 0 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 MEVGPFSTGQES(0.031)PT(0.969)AENAR;MEVGPFSTGQES(0.026)PT(0.974)AENAR;MEVGPFST(0.002)GQES(0.313)PT(0.686)AENAR 256.79 9.5729e-47 15122600.0 56183.4 38247.8 38162.5 60542.0 64381.6 49327.0 77868.0 76873.0 69838.0 34920.8 True False 53060.95154797007 41181.283273939254 35707.166298188335 52296.075159224696 56293.407829193355 56121.34650407666 81489.01629251488 77096.68770298969 83807.55143675892 33912.54576886526 1.5646407647958047 1.214337713087507 1.0529190743023102 1.5420863864262633 1.659958182227526 1.6548845045894802 2.402916514965062 2.2733972326480814 2.4712845802836108 1.0 15.049531469140126 -6.709718213164151 1.4716910520249171 2.1252546697852295 1.3073230813441266 0.32469136759260087 0.41955119683854086 0.3868503157149704 1.7450023163614494 0.17899194585627343 0.16936541661983193 1.9511101438775774e-07 6.709718213164151 -0.8179315884411029 MFGGPGTAS(ph)RPSSSR ddPTM_A459_Selumetinib_30min_R1 1 MFGGPGTASRPSSSR 15 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 MFGGPGT(0.035)AS(0.925)RPS(0.017)S(0.017)S(0.005)R 106.42 0.021307 8160900.0 2074.1 3287.9 2905.4 3421.1 3041.2 2587.5 2611.9 2392.8 1212.0 1956.6 True False 2122.422494503944 2902.9511394967576 2510.8626382198245 2823.6691070005436 2766.1239969674702 2561.472099262026 2414.882280147247 2329.335171090209 2056.675479022365 2207.748668897932 0.9613515000162671 1.3148920347649256 1.1372955054133047 1.2789812295119933 1.25291616565588 1.160219066303714 1.0938211917721197 1.0550726194086986 0.9315713821940701 1.0 11.108360229073128 -7.647459931848913 1.5210513320196737 0.9721589029994202 1.1971604955549868 0.45759136125289634 0.09396960374959537 0.34751702748188695 1.5328345546234663 0.06670767868214915 0.02855003184300875 2.251853163871209e-08 7.647459931848913 0.22500159255556662 MFGGPGTASRPS(ph)SSR ddPTM_A459_Selumetinib_30min_R1 1 MFGGPGTASRPSSSR 15 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 MFGGPGTAS(0.057)RPS(0.73)S(0.204)S(0.008)R 135.55 0.016294 8248400.0 1779.1 3311.0 2504.7 3802.1 2687.0 2086.9 2295.5 2059.8 1042.8 1950.1 True False 1820.54956847402 2923.3465807578614 2164.5754973322755 3138.134609256311 2443.9613244283796 2065.907680753595 2122.348586882348 2005.1674128266507 1769.555436901421 2200.41433058257 0.8273667114283976 1.328543692943452 0.9837126886731345 1.4261562314155056 1.110682333986313 0.938872126053931 0.964522252643413 0.9112681120813156 0.80419192526933 1.0 11.103559488591943 -6.7368554290461145 4.305647606221991 0.9184628754619637 1.1570998998165472 0.2975154895546914 0.162166466245081 0.24078853341421436 10.14877178460049 0.05393788210094707 0.05145734757727343 1.832924477415827e-07 6.7368554290461145 0.23863702435458345 MFGGPGTASRPSS(ph)SR ddPTM_A459_Selumetinib_30min_R1 2 MFGGPGTASRPSSSR 15 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 MFGGPGT(0.004)AS(0.033)RPS(0.214)S(0.691)S(0.058)R;MFGGPGT(0.002)AS(0.018)RPS(0.081)S(0.86)S(0.038)R 116.79 0.010524 108734000.0 4623.9 8425.7 7627.9 8665.0 7283.1 6114.0 6344.1 5860.700000000001 3053.0 4688.5 True False 4731.627873456819 7439.215126998341 6592.073077055484 7151.820412194825 6624.344890935739 6052.4987110678385 5865.559429335784 5705.255197763452 5180.718017702371 5290.314644857381 0.8943944152842305 1.4061952126476762 1.2460644630019349 1.3518705204324624 1.2521646320933189 1.144071594484718 1.1087354577364483 1.0784340026560477 0.9792835333033458 1.0 12.369137814766233 -7.425640969106358 1.2096640812860546 1.0026611152570675 1.2452684077811398 0.33369557787307635 0.12899753916477327 0.5327028699004696 1.479921034515657 0.09087234562329231 0.04530511076306401 3.752831202898258e-08 7.425640969106358 0.24260729252407232 MFGGPGTASRPSSSR ddPTM_A459_Selumetinib_30min_R1 1 MFGGPGTASRPSSSR 15 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 0 111.72 0.008976999999999999 20438000.0 1091.2 1156.3 1605.3 1664.9 1268.6 1208.4 1126.2 1177.2 561.38 955.07 False True 1116.6228368944135 1020.9198584507136 1387.3090772817106 1374.1564690436437 1153.8553539895213 1196.2445931394136 1041.2498272911785 1145.9768319154941 952.6208584270416 1077.6625376696047 1.0361525968129677 0.9473465233916412 1.2873316356358664 1.2751268797143058 1.070701925377011 1.1100363530556023 0.9662113981829905 1.063391174749023 0.883969540675544 1.0 10.073689763819099 -7.1717717962336875 1.9556878942625808 0.977879331865166 1.13211724494768 0.3044993778902939 0.10451879758248868 0.48504851973358803 3.638269226378515 0.05537406484505758 0.037643826754416826 6.733303705725194e-08 7.1717717962336875 0.154237913082514 MFIFSEEKR ddPTM_A459_Selumetinib_30min_R1 2 MFIFSEEKR 9 1 E9PLT2 E9PLT2 UBTF 0 ; 93.162 0.033734 77160000.0 5680.0 7278.6 6983.1 7690.7 6529.2 6198.299999999999 5978.2 4923.799999999999 2878.5 4115.1 False True 5812.332948643945 6426.418128270664 6034.83337542261 6347.663617318728 5938.635012823884 6135.950729606109 5527.2595609235705 4793.204829243548 4884.604262678115 4643.313169468406 1.2517641469591798 1.3840156572954994 1.299682609198964 1.3670548131573572 1.2789649967770262 1.3214595926788606 1.1903697552143275 1.032281186795829 1.0519652852183852 1.0 12.18093887179163 -7.561396896887079 2.0766500231316867 1.0219181782947606 1.322068788833887 0.9172734126220905 0.038840413276345374 0.07924768830550644 0.6780784080233592 0.021966919953435124 0.010974653603671084 2.745384030420666e-08 7.561396896887079 0.3001506105391263 MFIFSEEKR ddPTM_A459_Selumetinib_30min_R2 1 MFIFSEEKR 9 1 E9PLT2 E9PLT2 UBTF 0 85.161 0.048084 3868800.0 17034.0 16181.0 17607.0 14720.0 16697.0 13673.0 10300.0 11528.0 9888.7 13665.0 False True 16087.318472504729 17422.03066988456 16474.18478905214 12715.11060658366 14599.37358692609 15556.331638863912 10778.97040906281 11561.54457143687 11866.71631336347 13270.455944066109 1.212265693078781 1.312843412714454 1.2414181440705192 0.9581517515431885 1.100141068887253 1.1722529884754964 0.8122532077643219 0.8712243663795607 0.8942206931985391 1.0 13.695930318979702 -6.1928506604984035 0.6209277151007505 0.8922849462745528 1.3055124431461405 0.6082704205277347 0.10334580352949711 0.6739130095364144 0.5325929954442342 0.07397065400493974 0.15717542758590866 6.414301052551174e-07 6.1928506604984035 0.41322749687158766 MFPTPPSLEQHPAFS(ph)PVMNYK ddPTM_A459_Selumetinib_30min_R2 2 MFPTPPSLEQHPAFSPVMNYK 21 0 F8VRB8;H0YHC1;A0A3B3IS46;A0A3B3IRX3;Q71F56 F8VRB8 MED13L Mediator of RNA polymerase II transcription subunit 13-like 1 MFPTPPSLEQHPAFS(0.999)PVMNY(0.001)K;MFPTPPSLEQHPAFS(0.999)PVMNY(0.001)K 108.77 8.05e-05 11516900.0 52309.0 52006.0 62125.0 70104.0 68523.0 51332.0 50788.0 55502.0 49253.0 63472.0 True False 49401.875189518025 55994.692974353675 58127.94513658569 60555.71426385461 59914.52813660759 58402.51705449881 53149.74263451277 55663.501631149236 59104.97624380262 61639.39843993885 0.8014658877252832 0.9084237418201713 0.9430323236075266 0.9824189689790666 0.9720167563768168 0.9474868109137365 0.8622690029381392 0.90305069549612 0.9588830802979728 1.0 15.911565161714414 MFS(ph)PMEEK ddPTM_A459_Selumetinib_30min_R1 3 MFSPMEEK 8 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 MFS(1)PMEEK;MFS(1)PMEEK;MFS(1)PMEEK 121.5 0.006862899999999999 67641000.0 12833.7 16257.900000000001 13634.2 13366.599999999999 12821.199999999999 12737.1 14652.099999999999 14463.2 8911.9 13412.800000000001 True False 13132.700239966856 14354.41750990734 11782.750527299757 11032.37423215734 11661.524723766704 12608.976338361497 13546.880300526609 14079.588952905337 15122.843400577063 15134.463531735762 0.867734770540669 0.9484589579146477 0.7785377065128387 0.7289570726457091 0.7705277890632475 0.8331300486417296 0.8951014531912467 0.9302998367521625 0.9992322072642791 1.0 13.885549916702226 -7.727585107970491 1.4987622010198618 0.9978073522464717 0.8183193017721151 0.611593350259977 0.05687072343618615 0.32609127629730833 1.3768049692353894 0.05119064870812829 0.020471248462476863 1.8724701021950192e-08 7.727585107970491 -0.17948805047435656 MFS(ph)PMEEK ddPTM_A459_Selumetinib_30min_R2 2 MFSPMEEK 8 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 MFS(1)PMEEK;MFS(1)PMEEK 97.965 0.019842 8141400.0 72378.0 55453.0 67260.0 67433.0 65502.0 54837.0 67174.0 64694.0 50492.0 61935.0 True False 68355.52051209047 59706.066790501725 62932.56482715087 58248.50907158669 57273.05316469028 62390.29898927666 70297.7241027558 64882.24882933176 60591.8108643551 60146.775623544454 1.136478552731141 0.992672777077842 1.0463165177971057 0.9684394295075947 0.9522215043273367 1.037300808604842 1.1687696202161462 1.0787319545677125 1.0073991537567384 1.0 15.87619977835383 -7.008574144601193 24.905532252988788 1.0749646118069407 1.0142668677647833 0.08360180650450377 0.06432520392708158 749.7097843280189 2177702.1438939106 0.023630472786456608 0.019820506427023037 9.804509132824721e-08 7.008574144601193 -0.06069774404215744 MFT(ph)DMVAT(ph)ANNRQTFVNSAIR ddPTM_A459_Selumetinib_30min_R1 1 MFTDMVATANNRQTFVNSAIR 21 1 Q13231-4 Q13231-4 2 MFT(1)DMVAT(1)ANNRQTFVNSAIR 70.944 0.010682 5975700.0 765.12 725.37 2048.7 2693.4 1426.0 1045.7 899.89 861.87 466.63 465.36 True False 782.945807335643 640.4433431846356 1770.4977927035695 2223.048251379751 1297.0185517807488 1035.1812074196328 832.0105727944047 839.0104078516874 791.8370286932395 525.0934889902594 1.491059827919837 1.2196748895443188 3.371776321409334 4.233623722233945 2.4700716709987787 1.9714226687713425 1.5844998847621183 1.5978305300739528 1.5079924723803388 1.0 9.036430496544092 -6.97579624741275 2.5420660528782224 1.472899014285065 2.619163578626451 0.2994161358075518 0.8165424909629406 0.4336525512318052 5.661806744790353 0.3803620839387587 0.3084322234469251 1.0573134395796322e-07 6.97579624741275 1.146264564341386 MFVLDEADEMLSR ddPTM_A459_Selumetinib_30min_R1 2 MFVLDEADEMLSR 13 0 P60842;P60842-2;J3KT12;J3QS69;J3QL43;J3KTB5;J3KSZ0;J3QR64;Q14240-2;Q14240;E7EQG2;J3QLN6;J3KTN0 P60842 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 ; 208.84 0.00012729 17974000.0 2295.8 2619.0 2681.2 2599.5 2513.23 2551.9 2124.6000000000004 1980.42 1524.34 2002.19 False True 2349.28767315084 2312.3662624599333 2317.1077667773766 2145.5461236584483 2285.9087902467963 2526.230202939812 1964.3397114747277 1927.89282828923 2586.6936466113457 2259.190589482139 1.0398802491866583 1.0235374887029711 1.025636251126787 0.9496968222367903 1.011826448325806 1.118201454406237 0.8694882674440503 0.8533555501092759 1.144964775727168 1.0 11.141590268939888 -7.266248801573644 24.991626848122944 0.9547317865333445 1.0235015057844008 0.1046964151645895 0.08402722643066785 878.1023947666788 4562933.003539255 0.03429091612251171 0.023974559947308995 5.416904741740276e-08 7.266248801573644 0.06876971925105635 MFVLDEADEMLSR ddPTM_A459_Selumetinib_30min_R2 1 MFVLDEADEMLSR 13 0 P60842;P60842-2;J3KT12;J3QS69;J3QL43;J3KTB5;J3KSZ0;J3QR64;Q14240-2;Q14240;E7EQG2;J3QLN6;J3KTN0 P60842 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 187.31 0.0019373 8147100.0 4017.9 4355.2 4161.0 7963.5 7773.7 9130.1 3048.1 2654.2 4347.3 3976.1 False True 3794.6012029280746 4689.229835824809 3893.285790154253 6878.857562196262 6797.098308240247 10387.688400204153 3189.8426896955684 2661.923282573535 5216.881473710907 3861.2996618515353 0.9827264225093895 1.2144174880165277 1.0082837725905427 1.7814876245315223 1.7603135999501691 2.690205192523997 0.8261059666542441 0.689385314709585 1.3510687930419145 1.0 11.914870805761666 -5.736415979760655 24.87950205993867 1.4692379958427908 1.0830698511230699 0.0887403874651117 0.5442276465404722 610.6110527197013 607094.5983058878 0.16217012276457668 0.2807338822382137 1.8347800962226528e-06 5.736415979760655 -0.38616814471972094 MFVSSSGLPPS(ph)PVPSPR ddPTM_A459_Selumetinib_30min_R1 2 MFVSSSGLPPSPVPSPR 17 0 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309;Q7Z309-5 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 MFVSSSGLPPS(0.999)PVPSPR;MFVSSSGLPPS(0.999)PVPS(0.001)PR 193.31 8.579700000000001e-08 34319000.0 4079.6 4310.9 4356.8 5066.2 4359.5 3928.5 4136.9 4217.9 2182.56 3588.8 True False 4174.646742480252 3806.1778239169594 3765.170490189346 4181.483274352157 3965.183994732237 3888.9828567926093 3824.850302362701 4106.027590329903 3703.6449121246296 4049.4574378722778 1.0309150809777996 0.9399229112324871 0.9297962870225138 1.032603339707961 0.9791889544629166 0.9603713377553149 0.9445340174688703 1.0139698103574462 0.9146027508491731 1.0 11.983512907689779 -4.743548001428421 24.621563711770623 0.9689197515911627 1.030915314818983 0.21129496158474304 0.03625753095685315 1566.3759031984623 2155459.839278955 0.008789701930619136 0.2729038803569992 1.804895235776696e-05 4.743548001428421 0.06199556322782018 MFVSSSGLPPS(ph)PVPSPR ddPTM_A459_Selumetinib_30min_R2 1 MFVSSSGLPPSPVPSPR 17 0 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309;Q7Z309-5 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 MFVSSS(0.001)GLPPS(0.995)PVPS(0.005)PR 108.96 0.0022863 8149900.0 27492.0 26947.0 33994.0 39353.0 37776.0 29689.0 26181.0 27933.0 25467.0 31512.0 True False 25964.104699195737 29013.748251738427 31806.863049868683 33993.053512288476 33030.24115827516 33778.39026009148 27398.46837666732 28014.280405442914 30561.111607433475 30602.1666819913 0.8484400784103643 0.9480945762187609 1.0393663749497293 1.1108054493505075 1.0793432210704454 1.1037908070727984 0.8953113895948652 0.9154345408467008 0.9986584258891059 1.0 14.901346181183175 -10.588908686018037 14.642581095542024 1.0000000080447349 0.997349439677941 0.0 0.08626355027940469 0.0 0.0 0.09211920696467156 0.022342189439027937 2.5768629066384946e-11 10.588908686018037 -0.002650568366793893 MGAGLGHGMDR ddPTM_A459_Selumetinib_30min_R2 1 MGAGLGHGMDR 11 0 A0A087X0X3;P52272-2;P52272;M0R2T0;M0QZM1 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 115.0 0.008855700000000001 6334400.0 61777.0 53351.0 65958.0 63192.0 62097.0 46431.0 46154.0 43782.0 41867.0 54930.0 False True 58343.68165292505 57442.85014949704 61714.334089640506 54585.140587719696 54295.81970577648 52826.44879134719 48300.252452415974 43909.39837149972 50241.56986171977 53344.028174720224 1.0937247082621737 1.0768375039348688 1.1569117706579004 1.0232661922143262 1.0178425132788773 0.9902973322209979 0.905448165523156 0.8231361573910615 0.9418405692416248 1.0 15.70303915097499 -6.6267782659836545 1.173255864765148 0.90441869944355 1.101034871609808 0.6872531890951724 0.05118810861350936 0.24904563672667035 0.7257678488106233 0.02466938652293623 0.025338332872125474 2.3616837100567443e-07 6.6267782659836545 0.19661617216625793 MGANS(ph)LER ddPTM_A459_Selumetinib_30min_R2 1 MGANSLER 8 0 A0A087X0X3;P52272-2;P52272;M0QZM1;M0R2I7;M0QY96 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 MGANS(1)LER 88.134 0.031496 25288000.0 40182.0 35532.0 55541.0 47895.0 46670.0 29291.0 31771.0 38823.0 26929.0 35172.0 True False 37948.84530129066 38257.19014661257 51967.55252846848 41371.61837651656 40806.89736490632 33325.56937277573 33248.41445304218 38935.96850250638 32315.552459126568 34156.492972169304 1.1110287385830673 1.1200561538265803 1.52145457587849 1.2112373015059286 1.1947039585754826 0.9756730411383098 0.9734141757508002 1.1399287548119004 0.9461027654524504 1.0 15.059872232979831 -6.6481783824811505 4.149805700890505 1.0138689846516948 1.247390988695983 0.48331073475777697 0.11646117553081387 0.20857716200794219 6.486621640824534 0.0414936022485206 0.04117029711927045 2.2481310169442166e-07 6.6481783824811505 0.23352200404428824 MGESDDSILR ddPTM_A459_Selumetinib_30min_R1 1 MGESDDSILR 10 0 Q8WVC2;P63220 Q8WVC2 RPS21 40S ribosomal protein S21 0 136.57 0.025507 8452200.0 2193.9 2673.1 2139.4 2417.3 2665.6 2324.0 2012.2 2177.5 1319.7 1935.8 False True 2245.013601413723 2360.1322093095246 1848.8812308830088 1995.1639333408611 2424.496950649903 2300.6226700231696 1860.4181339684858 2119.745626483169 2239.43451292559 2184.2787862887753 1.0278054319376235 1.0805086896986877 0.8464492914040392 0.9134200020001879 1.1099759636311228 1.0532642098914808 0.8517310819693722 0.9704556212280704 1.0252512302838996 1.0 11.092941288322757 -11.431252758225002 14.74616245407842 1.0007044613893739 0.9841879242928357 0.001504277304778312 0.08670291634919924 0.0021948712520864434 1.3637927431440398e-05 0.09176054838137822 0.021317025660773113 3.704650493620178e-12 11.431252758225002 -0.01651653709653811 MGESDDSILR ddPTM_A459_Selumetinib_30min_R2 1 MGESDDSILR 10 0 Q8WVC2;P63220 Q8WVC2 RPS21 40S ribosomal protein S21 0 152.06 0.0089769 14636000.0 68695.0 63734.0 88668.0 87935.0 114880.0 69039.0 69080.0 72104.0 91527.0 82993.0 False True 64877.20690787326 68622.19286289002 82963.19741441876 75958.10130366396 100447.74735976938 78548.49557635673 72292.35687942314 72313.81070254014 109834.95747805262 80596.77644828972 0.804960319343516 0.8514260233089781 1.0293612359006357 0.9424458973541964 1.2462998123034845 0.9745860695402979 0.8969633782537862 0.8972295653652617 1.362771097284789 1.0 16.298434517371327 -5.18896170039141 1.9367463794781261 1.0409687379328538 0.7908614923232349 0.26961611407965747 0.14259085784735234 0.5863523146721137 3.7783611441421945 0.04023911823415371 0.19333165750617282 6.471996885478817e-06 5.18896170039141 -0.25010724560961894 MGFGS(ph)ISR ddPTM_A459_Selumetinib_30min_R2 1 MGFGSISR 8 0 Q674X7-3;A0A1B0GWK2;Q674X7-4;Q674X7-2;Q674X7 Q674X7-3 KAZN Kazrin 1 MGFGS(1)ISR 82.287 0.041681 1379400.0 14455.0 9835.0 15232.0 15615.0 16382.0 15670.0 10508.0 11876.0 9221.1 16352.0 True False 13651.648967949744 10589.312875490674 14251.989703347645 13488.210062622544 14323.94670306182 17828.400261902825 10996.64282120699 11910.557193822367 11065.577659060942 15879.875272401687 0.8596823799791128 0.6668385421070839 0.8974875091189656 0.8493901766384954 0.9020188419210079 1.1227040487457458 0.6924892439374839 0.7500409788811272 0.6968302627850158 1.0 13.954911960506754 -14.485643289537258 14.862043602882803 0.9353557722863702 0.8387059828566438 0.0 0.13913898209574854 0.0 0.0 0.0 0.032552931042023676 3.268561873036719e-15 14.485643289537258 -0.09664978942972646 MGIISIS(ph)T(ph)IQKM ddPTM_A459_Selumetinib_30min_R1 1 MGIISISTIQKM 12 1 X6RDV4;Q8WWT9-4 X6RDV4 SLC13A3 2 MGIISIS(1)T(1)IQKM 138.1 0.002071 296930000.0 0.0 221.5 0.0 0.0 66.259 174.68 238.55 0.0 0.0 150.93 True False 0.0 195.56667702744363 0.0 0.0 60.26588514897657 172.92287779675007 220.55598144229313 0.0 0.0 170.30333568269705 0.0 1.1483431974099223 0.0 0.0 0.3538737800254351 1.0153816254012409 1.2950772840599256 0.0 0.0 1.0 7.411962882722803 -6.55566548302573 24.790633805372213 0.6442062890501543 0.30920263313187024 0.11530009486145987 0.5008964488369642 477.10508735324396 360744.3066165842 0.17526161617342248 0.17526272463880002 2.781855177263054e-07 6.55566548302573 -0.33500365591828407 MGLLS(ph)PSGIGGVSPR ddPTM_A459_Selumetinib_30min_R2 1 MGLLSPSGIGGVSPR 15 0 M0QZ22;Q5PRF9;A0A087WZT0 M0QZ22 SAMD4B Protein Smaug homolog 2 1 MGLLS(0.948)PS(0.052)GIGGVSPR 153.41 0.00020807 10652000.0 16746.0 15045.0 19981.0 18159.0 22676.0 14544.0 14576.0 13306.0 12846.0 22321.0 True False 15815.324359549386 16198.903122700282 18695.444213667906 15685.71287397776 19827.238153987906 16547.303982713143 15253.812881796068 13344.718257073111 15415.558947229381 21676.534733077166 0.7296057489952993 0.7473013247814777 0.8624738429772963 0.7236264037185911 0.914686706068967 0.7633740441668886 0.7037016326470121 0.6156296853440244 0.7111634371939585 1.0 14.403846521712358 -7.001377574013177 24.995964253262205 0.7267278204560982 0.7972272129759692 0.0 0.10877919201753679 136.99774559742005 2485856.0295489617 0.037100202448861835 0.032280313508560816 9.968330440308077e-08 7.001377574013177 0.07049939251987103 MGLS(ph)MER ddPTM_A459_Selumetinib_30min_R2 3 MGLSMER 7 0 A0A087X0X3;P52272-2;P52272;M0QZM1;M0R2I7 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 MGLS(1)MER;MGLS(1)MER;MGLS(1)MER 101.25 0.020043 48870600.0 60031.0 79907.0 85092.0 74161.0 78283.0 48378.0 54742.0 51444.0 55005.0 73279.0 True False 56694.71734313328 86035.60995849852 79617.27336116457 64060.14386513932 68448.3896811006 55041.63036824093 57287.61146921515 51593.69352298732 66007.53696811094 71163.24486829281 0.7966853879142592 1.2089894174686824 1.1187976814227383 0.9001858190095219 0.9618503176433734 0.773455882599376 0.8050168535069144 0.7250047917077933 0.9275509722789633 1.0 16.118844674986782 -6.219532290921421 1.7514833763024111 0.832077277690702 1.0496415454778123 0.2510689322231855 0.12822404874486948 0.407551866275193 2.468893091214062 0.0440274412097991 0.06050592576115244 6.032088561158501e-07 6.219532290921421 0.21756426778711024 MGMGNNYSGGYGT(ph)PDGLGGYGR ddPTM_A459_Selumetinib_30min_R1 1 MGMGNNYSGGYGTPDGLGGYGR 22 0 P31942;P31942-4;P31942-3;P31942-2 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 MGMGNNYS(0.042)GGYGT(0.958)PDGLGGYGR 173.03 7.1459e-12 5758100.0 931.73 994.22 1114.2 854.19 459.7 779.97 594.62 496.3 535.08 762.28 True False 953.4374961690177 877.8162601996614 962.8977598625069 705.021751632164 418.1202161666267 772.1242099560981 549.7673346686918 483.1365117904006 907.9916793030419 860.1260632359788 1.1084857637983685 1.0205669816551406 1.1194844581733507 0.8196725826208787 0.48611504061807953 0.8976872611570461 0.639170649707264 0.5617043041025143 1.0556495357052458 1.0 9.74840431177191 -5.850098912880142 4.9595875302881876 0.7434877662445174 1.075984384090853 0.38095095391809275 0.17454519601446572 0.19088317668045038 7.96208261929561 0.04765938156473009 0.07285474396285703 1.4122158683107133e-06 5.850098912880142 0.33249661784633555 MGMGNNYSGGYGT(ph)PDGLGGYGR ddPTM_A459_Selumetinib_30min_R2 4 MGMGNNYSGGYGTPDGLGGYGR 22 0 P31942;P31942-4;P31942-3;P31942-2 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 MGMGNNYS(0.007)GGY(0.033)GT(0.943)PDGLGGY(0.017)GR;MGMGNNYS(0.026)GGYGT(0.974)PDGLGGYGR;MGMGNNY(0.001)S(0.009)GGY(0.041)GT(0.949)PDGLGGYGR;MGMGNNY(0.007)S(0.043)GGY(0.067)GT(0.882)PDGLGGY(0.001)GR 232.6 1.7256999999999993e-70 12183600.0 28604.8 23001.600000000002 34141.1 39972.8 40697.4 24066.1 22105.2 28890.9 29990.2 28445.6 True False 27015.059730087087 24765.74875819893 31944.498796019056 34528.43568307387 35584.6287726278 27380.986824695596 23133.13560062283 28974.967735854032 35989.07799620104 27624.301617455312 0.9779454374700551 0.8965203573707683 1.1563911818800112 1.249929723517642 1.2881639241204381 0.9911920020231038 0.8374197444327572 1.0488941272471937 1.30280499013449 1.0 14.75365037108447 -5.259994964454066 24.957101094664026 1.1085709511346113 0.9372328897236578 0.1929648158018732 0.14078862704334322 221.76222021850262 3831588.763763846 0.0400854526877161 0.09523808211734708 5.495472456962529e-06 5.259994964454066 -0.17133806141095353 MGMGNNYSGGYGTPDGLGGY(ph)GR ddPTM_A459_Selumetinib_30min_R2 1 MGMGNNYSGGYGTPDGLGGYGR 22 0 P31942;P31942-4;P31942-3;P31942-2 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 MGMGNNYSGGY(0.001)GT(0.024)PDGLGGY(0.974)GR 110.22 0.00068408 3277500.0 10541.0 8399.6 8614.1 10662.0 11474.0 5068.5 9566.4 9802.2 8890.0 9950.1 True False 9955.17341896633 9043.82231102913 8059.8781843229435 9209.81720702411 10032.533541138533 5766.639867738004 10011.256555461981 9830.72277915843 10668.24840735398 9662.814759535475 1.0302560554772457 0.9359407725481325 0.8341128734118888 0.9531195036038194 1.038262016897117 0.5967867553341389 1.0360600719974122 1.0173767192895071 1.1040518392248306 1.0 13.238227789262293 -7.467644303284308 24.99997852845178 1.0417750097298857 0.898321510873495 0.25143295336538274 0.11944575664120698 425.0288581864595 192375.06963747117 0.04976545180933816 0.03355321250954962 3.406871056856552e-08 7.467644303284308 -0.1434534988563907 MGNLQNS(ph)PVNMNPPPLSK ddPTM_A459_Selumetinib_30min_R2 2 MGNLQNSPVNMNPPPLSK 18 0 E7EWM1;Q15596 E7EWM1 NCOA2 Nuclear receptor coactivator 2 1 MGNLQNS(1)PVNMNPPPLSK;MGNLQNS(1)PVNMNPPPLSK 167.93 1.4285e-06 4806200.0 56421.0 46964.0 53173.0 58481.0 64237.0 43992.0 42805.0 49495.0 37604.0 54184.0 True False 53285.346691158236 50565.98778693892 49751.907070385045 50515.78691464803 56166.97377393372 50051.4986803848 44795.517316498364 49639.022255661665 45125.8507435477 52619.56713306096 1.012652699259454 0.9609730855267379 0.9455020210366922 0.960019051219235 1.0674161121831791 0.9511955610318459 0.8513091185874326 0.9433567199467399 0.8575868864416228 1.0 15.683311759988733 -7.003902066939464 24.98883261501546 0.907329963982769 0.9862397371622905 0.3311148009766498 0.050765253473624004 182.2664808899256 1167239.420113981 0.017573096073169512 0.015161996946874444 9.910554019026708e-08 7.003902066939464 0.07890977317952153 MGPLGLDHMAS(ph)SIER ddPTM_A459_Selumetinib_30min_R1 1 MGPLGLDHMASSIER 15 0 A0A087X0X3;P52272-2;P52272;M0QZM1 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 MGPLGLDHMAS(0.5)S(0.5)IER 87.419 0.012355 3200000.0 1246.9 1520.1 1918.0 2047.4 1825.3 1604.7 1738.7 1772.3 804.09 1373.6 True False 1275.9503439549533 1342.1259853246827 1657.5461348198608 1689.860024457898 1660.2019372828893 1588.5581749510236 1607.5484591645989 1725.2928467582644 1364.4820015900098 1549.914939997035 0.8232389475240456 0.8659352527611937 1.0694432913996117 1.0902921062630255 1.0711568063767845 1.0249324875557768 1.0371849562064832 1.1131532461785065 0.8803592806148576 1.0 10.59797332660564 -5.1975269315098025 4.917135851563158 1.0427486506000592 0.8365539061315823 0.6070312231069268 0.06152264413387082 0.12910793026045844 6.262248188205447 0.015241632564088066 0.042485395999857706 6.345605493333591e-06 5.1975269315098025 -0.20619474446847685 MGPPVGGHR ddPTM_A459_Selumetinib_30min_R2 1 MGPPVGGHR 9 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 101.33 0.0222 0.0 16017.0 14445.0 15743.0 16227.0 18076.0 12439.0 13634.0 17176.0 13100.0 16987.0 False True 15126.839261131172 15552.88505200436 14730.112519682376 14016.854606863655 15805.131278509685 14152.359340000592 14268.008015258481 17225.979316360128 15720.366044582355 16496.54117247355 0.9169703577845828 0.9427967286837199 0.8929212715366861 0.8496844556877445 0.9580875841344509 0.857898585651124 0.8649090658511105 1.0442176415201347 0.9529492200955231 1.0 14.00987594605612 -7.757260970525715 24.999989414363807 0.9989375775416269 0.8981227957923446 0.5869450312552659 0.03899691437350699 72.89173353525176 436129.6021490963 0.019032138475064436 0.01048315727556526 1.7487955096385745e-08 7.757260970525715 -0.10081478174928238 MGPSGGEGMEPERRDS(ph)QDGSSYR ddPTM_A459_Selumetinib_30min_R1 4 MGPSGGEGMEPERRDSQDGSSYR 23 2 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 MGPSGGEGMEPERRDS(0.995)QDGS(0.004)S(0.001)YR;MGPSGGEGMEPERRDS(0.874)QDGS(0.088)S(0.035)Y(0.003)R;MGPSGGEGMEPERRDS(0.987)QDGS(0.009)S(0.004)YR;MGPSGGEGMEPERRDS(0.856)QDGS(0.052)S(0.052)Y(0.04)R 94.188 0.00010003 661155000.0 4568.6 4717.05 6986.0 7849.400000000001 5895.5 5073.8 5254.65 4201.03 2755.9100000000003 3106.8599999999997 True False 4675.03949105189 4164.775593102951 6037.339571351168 6478.649641486675 5362.253065935066 5022.762178641804 4858.287519957013 4089.605037531385 4676.577986297463 3505.6557443791426 1.3335706161529695 1.1880161364334247 1.7221712602645731 1.8480564304907396 1.5296005817264666 1.432759673192424 1.3858427279251926 1.1665734846008562 1.334009477055966 1.0 11.775468614968885 -7.886721234592274 0.9212703518425666 1.0748227357323459 1.5289249641317222 0.414247481051255 0.1859738341550284 0.6220020462304445 0.9775193036787069 0.18891471024569073 0.0753303412230068 1.298012173088795e-08 7.886721234592274 0.4541022283993763 MGPSGGEGMEPERRDS(ph)QDGSSYR ddPTM_A459_Selumetinib_30min_R2 4 MGPSGGEGMEPERRDSQDGSSYR 23 2 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 1 MGPS(0.001)GGEGMEPERRDS(0.881)QDGS(0.067)S(0.031)Y(0.02)R;MGPSGGEGMEPERRDS(0.886)QDGS(0.043)S(0.043)Y(0.028)R;MGPSGGEGMEPERRDS(0.691)QDGS(0.109)S(0.109)Y(0.091)R;MGPSGGEGMEPERRDS(0.9)QDGS(0.016)S(0.016)Y(0.067)R 78.40100000000002 0.00027653 383694000.0 241981.0 262621.0 235981.0 262702.0 268023.0 199609.5 89606.8 174979.0 130782.20000000001 279520.0 True False 228532.6647466932 282763.18624038954 220798.23937668614 226921.53441377272 234351.5545839786 227103.89675036963 93773.69375250579 175488.15992066715 156942.29435998297 271449.531319822 0.8418974371977672 1.0416786680955354 0.8134043860865668 0.8359621521925327 0.8633337970580817 0.8366339615550696 0.34545535332688254 0.6464854039991209 0.5781638067190967 1.0 18.050324467373258 -7.0298338570500585 24.4190732380985 0.6099205304016635 0.8789921523278295 0.3236820316711838 0.16083865902106537 520.1719069016531 425760.13624351413 0.05798474528786046 0.044994248576824936 9.336113932569421e-08 7.0298338570500585 0.26907162192616596 MGQAPSQSLLPPAQDQPRS(ph)PVPSAFSDQSR ddPTM_A459_Selumetinib_30min_R1 7 MGQAPSQSLLPPAQDQPRSPVPSAFSDQSR 30 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MGQAPSQSLLPPAQDQPRS(0.976)PVPS(0.023)AFSDQSR;MGQAPSQSLLPPAQDQPRS(0.907)PVPS(0.085)AFS(0.006)DQS(0.001)R;MGQAPSQSLLPPAQDQPRS(0.803)PVPS(0.193)AFS(0.004)DQS(0.001)R;MGQAPSQSLLPPAQDQPRS(0.907)PVPS(0.084)AFS(0.008)DQSR;MGQAPS(0.026)QS(0.026)LLPPAQDQPRS(0.788)PVPS(0.13)AFS(0.025)DQS(0.005)R;MGQAPS(0.001)QSLLPPAQDQPRS(0.856)PVPS(0.107)AFS(0.035)DQS(0.001)R;MGQAPSQSLLPPAQDQPRS(0.872)PVPS(0.119)AFS(0.01)DQSR 107.58 4.4498e-11 754847000.0 6315.49 7145.43 9791.41 10836.37 9493.859999999999 7282.98 7415.820000000001 6747.290000000001 4054.32 5295.02 True False 6462.6286291956585 6308.839733779713 8461.79030236524 8944.001403357839 8635.142039277125 7209.719833616758 6856.438726889066 6568.329950913258 6879.88492418313 5974.687394862479 1.081668077689345 1.0559280037319718 1.416273311578004 1.4969823209576818 1.4452876725738524 1.206710804621554 1.147581165967744 1.099359601066533 1.1515054210365907 1.0 12.54464751563333 -7.148123376148255 3.00936011963003 1.1045966600672652 1.303873030671671 0.3047481047641618 0.14055325734729848 0.3994008823290548 6.924476093228338 0.0675874996596293 0.05001944267481023 7.110114979128462e-08 7.148123376148255 0.19927637060440584 MGQAPSQSLLPPAQDQPRS(ph)PVPSAFSDQSR ddPTM_A459_Selumetinib_30min_R2 6 MGQAPSQSLLPPAQDQPRSPVPSAFSDQSR 30 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MGQAPSQSLLPPAQDQPRS(0.957)PVPS(0.026)AFS(0.009)DQS(0.007)R;MGQAPSQSLLPPAQDQPRS(0.954)PVPS(0.044)AFS(0.002)DQSR;MGQAPSQSLLPPAQDQPRS(0.728)PVPS(0.023)AFS(0.08)DQS(0.168)R;MGQAPS(0.003)QS(0.003)LLPPAQDQPRS(0.909)PVPS(0.049)AFS(0.018)DQS(0.018)R;MGQAPSQSLLPPAQDQPRS(0.992)PVPS(0.007)AFSDQSR;MGQAPSQSLLPPAQDQPRS(0.972)PVPS(0.024)AFS(0.004)DQSR 104.54 5.6768999999999986e-11 558972000.0 251718.8 292203.4 313578.6 315794.0 309409.6 237192.0 157986.1 181236.5 131864.4 292327.3 True False 237729.27680619506 314614.46119798155 293403.2942745643 272782.31242496445 270538.7998910802 269863.0449854025 165332.76669351824 181763.8682096824 158240.9645991777 283887.05129145924 0.837407961105365 1.1082381523452274 1.0335212294460552 0.9608832498136949 0.9529804147823749 0.9506000494131074 0.5823892493207642 0.6402682594461496 0.557408180046634 1.0 18.114957520527533 -7.198661342219504 6.138841673850752 0.6654733174022318 0.9831314760222123 0.5144974722371252 0.1314181190974858 0.15822921262833478 12.0239568982761 0.048276170819146154 0.037045004243620845 6.329051911000372e-08 7.198661342219504 0.3176581586199805 MGS(ph)KSPGNTSQPPAFFSK ddPTM_A459_Selumetinib_30min_R1 1 MGSKSPGNTSQPPAFFSK 18 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5;H7C184 C9J0Q5;Q9Y618;H7C184 NCOR2 Nuclear receptor corepressor 2 1 MGS(0.608)KS(0.387)PGNT(0.004)S(0.002)QPPAFFSK 92.551 0.0027215 71950000.0 3578.1 2844.9 9457.2 11056.0 6438.5 5201.3 3478.4 3773.9 2861.5 2377.9 True False 3661.4627682293844 2511.817785441871 8172.964184681124 9125.277146823544 5856.138811809503 5148.979644402546 3216.0214875240936 3673.80391264516 4855.756504308991 2683.1266277074474 1.364625407693807 0.9361532771146368 3.0460598095828133 3.4009863912462768 2.1825801105828475 1.9190222299728006 1.1986096572236582 1.3692249462650894 1.8097381070896048 1.0 11.389699427540311 -7.055037896105529 3.4698062716769775 1.3785942567035427 2.225113217874255 0.24468889687248763 0.694960382143273 0.4161578715986072 9.993995546315292 0.3119153020357926 0.24506229781466152 8.809719969117583e-08 7.055037896105529 0.8465189611707122 MGS(ph)KSPGNTSQPPAFFSK ddPTM_A459_Selumetinib_30min_R2 1 MGSKSPGNTSQPPAFFSK 18 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5;H7C184 C9J0Q5;Q9Y618;H7C184 NCOR2 Nuclear receptor corepressor 2 1 MGS(0.575)KS(0.423)PGNT(0.002)SQPPAFFSK 64.069 0.019812 16779000.0 62446.0 112740.0 86231.0 109330.0 101150.0 37146.0 19712.0 21109.0 16188.0 92547.0 True False 58975.50131114422 121386.79548376388 80682.99134121415 94439.06539523021 88442.63270752675 42262.52432218523 20628.647058586997 21170.423695216923 19426.05233051139 89874.92764401645 0.6561952577557439 1.3506191177651021 0.89772524391663 1.0507832147503 0.9840634649280292 0.4702370886971047 0.2295261604025378 0.23555427804148416 0.21614540161251194 1.0 16.455631083625327 -6.80106991201089 3.973493738002423 0.356288239848622 1.0114973257593798 0.5128522414165317 0.2686189920441152 0.15240857675008088 5.093817243088758 0.09082289871134686 0.08253371830189078 1.5809935130507588e-07 6.80106991201089 0.6552090859107578 MGS(ph)PAPLLPGDLLGGGSDSI ddPTM_A459_Selumetinib_30min_R1 4 MGSPAPLLPGDLLGGGSDSI 20 0 Q9UPQ9;Q9UPQ9-1;Q9UPQ9-2 Q9UPQ9;Q9UPQ9-2 TNRC6B Trinucleotide repeat-containing gene 6B protein 1 MGS(1)PAPLLPGDLLGGGSDSI;MGS(1)PAPLLPGDLLGGGSDSI;MGS(1)PAPLLPGDLLGGGSDSI;MGS(1)PAPLLPGDLLGGGSDSI 111.7 0.00034511 5688420.0 2634.57 3273.5 3430.1400000000003 3644.8500000000004 3006.47 3251.5699999999997 2993.05 2644.72 1443.272 2527.74 True False 2695.9503550191694 2890.2370981911386 2964.3458284103212 3008.3453698082303 2734.5353193353894 3218.8621579893434 2767.2818287816217 2574.5734343387235 2449.1271715837984 2852.2000512726468 0.9452178341474473 1.013336037527073 1.0393190432373898 1.0547455703417128 0.9587459750992027 1.1285541336951777 0.9702271155723685 0.9026622915843344 0.8586800110640914 1.0 11.477859459591567 -7.535267104503006 6.464577331826632 0.9145286268428925 1.0243336364184195 0.3906895512742268 0.05769505228013374 0.14345251054291916 25.979175854491984 0.026051154810481442 0.015451601487674365 2.9156332580581548e-08 7.535267104503006 0.10980500957552697 MGS(ph)PAPLLPGDLLGGGSDSI ddPTM_A459_Selumetinib_30min_R2 2 MGSPAPLLPGDLLGGGSDSI 20 0 Q9UPQ9;Q9UPQ9-1;Q9UPQ9-2 Q9UPQ9;Q9UPQ9-2 TNRC6B Trinucleotide repeat-containing gene 6B protein 1 MGS(1)PAPLLPGDLLGGGSDSI;MGS(1)PAPLLPGDLLGGGSDSI 96.435 0.00099609 6873900.0 40296.0 30531.0 35105.0 44065.0 34217.0 32491.0 35981.0 34317.0 28906.0 33622.0 True False 38056.509637668816 32872.629527362056 32846.38251943404 38063.27098363513 29918.354556138842 36966.340326067955 37654.18779499889 34416.85678851481 34688.00770112193 32651.245499552944 1.165545419643789 1.0067802628788585 1.0059764035611984 1.1657524973788913 0.91630056061869 1.132157127867422 1.153223628039379 1.0540748526418706 1.062379311122967 1.0 14.994850404759337 -7.993720487257404 24.970551012228913 1.040202098310759 1.0739811730471602 0.049996531794574084 0.07910854544857919 651.7170684742572 2591561.3178757587 0.04298761089774373 0.020546241260224293 1.0145641510429735e-08 7.993720487257404 0.03377907473640129 MGS(ph)SPLEVPKPR ddPTM_A459_Selumetinib_30min_R1 1 MGSSPLEVPKPR 12 1 Q8NCE2-2;Q8NCE2 Q8NCE2-2 MTMR14 Myotubularin-related protein 14 1 MGS(0.611)S(0.389)PLEVPKPR 154.36 0.0021095 8886900.0 1977.3 1953.6 2039.3 2450.9 2115.4 1885.4 1784.4 1424.4 923.06 1514.0 True False 2023.3672428439559 1724.8716037959987 1762.3742610730671 2022.8963240909743 1924.0624435042032 1866.434587806232 1649.8012713713172 1386.6202848967284 1566.3654023650035 1708.336647608848 1.1844077955454828 1.00967897996586 1.0316317123676153 1.1841321363224364 1.1262782696825628 1.0925449561821865 0.9657354559948927 0.8116785920606313 0.9168950420617851 1.0 10.738376587476601 -7.370494981850976 3.3767251473662565 0.8968871886865069 1.1024485164417304 0.6321754745146522 0.06824767548735379 0.1585006352209642 3.379330762876737 0.03156892641421257 0.020214926794448553 4.260936069445939e-08 7.370494981850976 0.2055613277552235 MGS(ph)SPLEVPKPR ddPTM_A459_Selumetinib_30min_R2 1 MGSSPLEVPKPR 12 1 Q8NCE2-2;Q8NCE2 Q8NCE2-2 MTMR14 Myotubularin-related protein 14 1 MGS(0.766)S(0.234)PLEVPKPR 73.415 0.029858 8670600.0 43059.0 36024.0 35598.0 43227.0 44601.0 38522.0 36297.0 41247.0 31102.0 53158.0 True False 40665.9531588342 38786.92496458326 33307.66343617186 37339.40802926572 38997.82364200102 43828.055832100916 37984.882421141025 41367.02194119154 37323.26906248857 51623.190418929094 0.7877458333904696 0.7513469169538376 0.6452073799754667 0.7233068651172357 0.7554322645603355 0.8489993639763521 0.7358104393178458 0.801326334259712 0.7229942349476127 1.0 15.655731685245826 -14.522878745233115 0.26474995842629323 2.6418957241923033 0.7338652023350553 0.6726561012710539 0.05168559266778939 124.39190986229704 1.214202235861044 111.3671075375241 0.06916899624136438 3.0000000003262037e-15 14.522878745233115 -1.9080305218572482 MGSDEFDIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 MGSDEFDISPR 11 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 MGSDEFDIS(1)PR;MGSDEFDIS(1)PR 140.63 0.0010705 5138900.0 6790.1 8785.099999999999 9217.1 9836.7 8918.6 8656.1 8308.0 6769.3 4317.9 6798.5 True False 6948.296118765356 7756.536407917815 7965.468445906225 8118.905002727851 8111.914204706714 8569.02749310996 7681.320871190823 6589.756174214702 7327.160933061609 7671.153697997846 0.9057693786762278 1.0111303609967108 1.0383664256375404 1.0583681832430063 1.057456873380585 1.1170454706632271 1.0013253773282669 0.8590306534901802 0.9551576231582978 1.0 12.905227851857461 -7.536469880985659 23.531897395991027 0.9302919788430333 1.035337615539922 0.32467567589121227 0.059694740173798985 126.07956903184072 218290.51179759836 0.02868618463452818 0.0165770084008106 2.9075695970367883e-08 7.536469880985659 0.10504563669688882 MGSDEFDIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 MGSDEFDISPR 11 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 MGSDEFDIS(1)PR 132.86 0.0019305 2135700.0 23924.0 26035.0 32789.0 31181.0 31485.0 24125.0 25033.0 30025.0 21277.0 28009.0 True False 22594.39985536006 28031.800784280593 30679.391437963885 26934.094009774795 27529.572820528716 27447.999765054607 26197.084101948476 30112.36777909366 25532.99452905182 27200.307393878356 0.8306670776979935 1.0305692644704953 1.1279060561230467 0.9902128538384285 1.0121052097640801 1.0091062342638082 0.9631172075593651 1.1070598336646256 0.9387024256497271 1.0 14.731335335183815 -4.76012630003927 24.94670352820954 1.02330765617065 0.8306668387960932 0.5107750516820422 0.05545683859350946 25.693804494094874 487955.64298447175 0.013333697894956897 0.0809047035675671 1.7372955209218213e-05 4.76012630003927 -0.19264081737455685 MGVS(ph)RSAS(ph)TVIAY(ph)AMK ddPTM_A459_Selumetinib_30min_R1 1 MGVSRSASTVIAYAMK 16 1 Q8WYL5-4;Q8WYL5;Q8WYL5-2;Q8WYL5-5;F5H527;Q76I76;A0A3B3IS79;Q76I76-4 Q8WYL5-4;F5H527 SSH1;SSH2 Protein phosphatase Slingshot homolog 1;Protein phosphatase Slingshot homolog 2 3 MGVS(0.984)RS(0.032)AS(0.979)T(0.12)VIAY(0.885)AMK 78.32600000000002 0.013477 2624700.0 257.29 241.01 391.7 473.78 419.54 266.04 237.13 71.774 0.0 352.67 True False 263.28435640081005 212.79243715749072 338.50929145408713 391.04321695206727 381.5926810758029 263.36387914499323 219.24309318554168 69.87032036519082 0.0 397.93862979670547 0.6616205029788484 0.5347368192582856 0.8506570262530708 0.9826721702083538 0.9589234432222545 0.6618203396828745 0.5509469972732886 0.1755806426756945 0.0 1.0 8.636402144878284 -7.3813531743047465 2.542650349169041 0.3231280883695863 0.7914510792338338 0.27300841824390887 0.2747425869072345 0.32741830983184 4.119651966068402 0.1363066712583774 0.08295699251045834 4.155725236959173e-08 7.3813531743047465 0.46832299086424756 MHDLNTDQENLVGTHDAPIR ddPTM_A459_Selumetinib_30min_R1 2 MHDLNTDQENLVGTHDAPIR 20 0 J3QT28;O43684-2;O43684;J3QSX4 J3QT28 BUB3 Mitotic checkpoint protein BUB3 0 ; 81.639 0.0019574 33040000.0 2548.8999999999996 3584.0 3044.1 3035.26 2758.3 2759.0 2338.43 2954.6 1823.0900000000001 3087.8 False True 2608.284410703969 3164.3836138436027 2630.727940044389 2505.208819886726 2508.8122520174184 2731.2469649715686 2162.040342419206 2876.2344101066246 3093.6505767746557 3484.1492077190196 0.7486144407723411 0.9082227611931812 0.7550560504745596 0.7190302913366962 0.7200645272192208 0.7839064294148423 0.6205360946165209 0.8255198726089057 0.88792138118562 1.0 11.766590692934965 -8.39662817319517 2.1190518313274094 0.9935084378571134 0.7556199090955473 0.5638904208043707 0.06928364567459123 0.22693173173803738 2.080551916815368 0.06836238322295703 0.019236652802681848 4.012100717844992e-09 8.39662817319517 -0.23788852876156608 MHFTIRLT(ph)ESAIT(ph)Y(ph)RDIVVKK ddPTM_A459_Selumetinib_30min_R2 1 MHFTIRLTESAITYRDIVVKK 21 3 C9JMH9;Q9Y6F7 C9JMH9 CDY2A Testis-specific chromodomain protein Y 2 3 MHFT(0.321)IRLT(0.348)ES(0.348)AIT(0.987)Y(0.997)RDIVVKK 48.112 0.043625 0.0 3079.0 2620.0 2565.7 3193.8 2826.8 2030.6 2194.8 2700.8 1167.8 2019.3 True False 2907.881506213578 2820.9455753721973 2400.6256553229427 2758.7989303876952 2471.672112087364 2310.296718048493 2296.862548913693 2708.6588808584893 1401.3926310582651 1960.9975622285176 1.482858297339749 1.4385257940690233 1.2241859457463184 1.406834451773892 1.2604156984665016 1.1781231973705386 1.1712725161695212 1.3812658072763304 0.7146325207389315 1.0 10.937372026738291 -7.157080763313642 0.3812288682779755 0.9316326874597766 1.475366863506564 0.5279029638208386 0.15162814359381835 1.1407017690424 0.38860823962896446 0.16793366909450416 0.22347054238696878 6.964969784225043e-08 7.157080763313642 0.5437341760467874 MHLPS(ph)PTDSNFYR ddPTM_A459_Selumetinib_30min_R1 2 MHLPSPTDSNFYR 13 0 P00533;E9PFD7;Q504U8 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 MHLPS(0.985)PT(0.014)DS(0.001)NFYR;MHLPS(0.999)PT(0.001)DSNFYR 97.2 0.008971600000000001 8580600.0 5235.5 3733.2 6936.0 4622.7 7391.1 4809.7 4959.8 6186.6 2485.46 4245.0 True False 5357.476963490379 3296.115208482406 5994.129296720827 3815.432223826085 6722.576310004688 4761.31878485819 4585.67829284211 6022.511271091054 4217.644089183929 4789.887099801553 1.1184975453205028 0.6881404801000353 1.2514134825785699 0.7965599489775366 1.403493687833103 0.9940357018134005 0.9573666763527885 1.2573388778496617 0.8805310023609259 1.0 12.225775935931269 -5.269011363504267 24.99552114792912 1.0725361702182004 0.9033190088472091 0.09573089498317666 0.20149499893826842 1136.1761684131075 3750587.0781194353 0.04873250558625197 0.10461266135044629 5.382556986372532e-06 5.269011363504267 -0.1692171613709913 MIS(ph)TVVWLMVLLIMVPNMMIPIK ddPTM_A459_Selumetinib_30min_R2 1 MISTVVWLMVLLIMVPNMMIPIK 23 0 O14626 O14626 GPR171 Probable G-protein coupled receptor 171 1 MIS(0.836)T(0.164)VVWLMVLLIMVPNMMIPIK 63.578 0.045197 0.0 13946.0 14181.0 10026.0 11497.0 11197.0 7973.9 9135.1 11889.0 8734.3 8635.6 True False 13170.937150261307 15268.637100898151 9380.938075483424 9931.088766568773 9790.332757549952 9072.23234514276 9559.90025085725 11923.5950216701 10481.404056732496 8386.267790016629 1.57053620037516 1.8206713025637684 1.1186070264356325 1.184208400594024 1.1674242944167346 1.081796166340256 1.1399469335140673 1.421799937734454 1.249829401967107 1.0 13.033813183670697 -5.2656540899251585 24.99474691139837 1.1816432828125734 1.6956037688805654 0.7554803160010188 0.11937045173452629 154.9902831721121 919153.8163521439 0.03166438801583408 0.06989608102782632 5.4243275923798655e-06 5.2656540899251585 0.513960486067992 MISTPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 MISTPSPK 8 0 Q53F19;Q53F19-2 Q53F19 C17orf85 Uncharacterized protein C17orf85 1 MIS(0.002)T(0.037)PS(0.962)PK;MIS(0.036)T(0.036)PS(0.928)PK 123.96 0.005656899999999999 205582000.0 12831.1 15854.7 17579.4 18451.4 12969.6 14609.7 13005.400000000001 13718.8 8877.7 13427.9 True False 13130.039665025584 13998.424353349934 15192.214036732144 15229.209365674737 11796.501969968855 14462.739682546262 12024.392207292394 13354.932859057313 15064.808498446235 15151.501763822216 0.8665833835941366 0.9238968236649963 1.0026870123862666 1.0051287062539283 0.7785698179526854 0.9545416624693576 0.7936105869058779 0.8814263475152915 0.9942782394295078 1.0 13.887173175217516 -1.5491658007017657 23.10485533148376 0.9150563572425341 0.00204594536910796 0.0 0.08232811748332576 0.0 0.0 0.018845146907256485 0.0 0.028238017256889018 1.5491658007017657 -0.9130104118734261 MISTPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 MISTPSPK 8 0 Q53F19;Q53F19-2 Q53F19 C17orf85 Uncharacterized protein C17orf85 1 MIS(0.008)T(0.079)PS(0.913)PK;MISTPS(1)PK;MIST(0.001)PS(0.998)PK 123.96 0.005656899999999999 201183000.0 2022530.0 1810640.0 1735490.0 1746310.0 1574810.0 1166330.0 1738240.0 1530900.0 1124870.0 1488120.0 True False 1910125.879429084 1949510.2658747796 1623830.4628586443 1508459.5654472208 1376968.2888199713 1326981.3706104108 1819071.6042572164 1535354.665545863 1349875.4314938446 1445154.1089999054 1.3217454578259162 1.3489981820858574 1.1236382699575127 1.0438053326306667 0.9528176131837448 0.9182282791478384 1.2587388382517033 1.0624158738394893 0.934070230356265 1.0 20.462791917022386 -5.401170171707035 2.6879660436943005 1.0297910316668628 1.3420152097135276 0.6431908383203753 0.09129818574000209 0.18471652111978107 2.5455394530044275 0.0268437790617016 0.06894617311298919 3.9703594647117445e-06 5.401170171707035 0.3122241780466648 MITNSLNHDS(ph)PPSTPPR ddPTM_A459_Selumetinib_30min_R2 1 MITNSLNHDSPPSTPPR 17 0 Q8N9M1-2;Q8N9M1;J3QKZ5;J3QS16;Q8N9M1-3 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 MIT(0.004)NS(0.004)LNHDS(0.916)PPS(0.031)T(0.045)PPR 74.214 0.01551 17262000.0 21277.0 19292.0 23137.0 25082.0 22768.0 14892.0 15630.0 17384.0 15159.0 19472.0 True False 20094.509518579514 20771.63436644292 21648.3906096609 21665.78833113662 19907.680291497476 16943.237823883665 16356.825970257445 17434.58456192387 18191.223577849138 18909.792765668164 1.0626509643755733 1.0984591224159281 1.1448243181683524 1.145744355827745 1.0527709392797278 0.8960033583575334 0.8649923440702227 0.921987077170797 0.9620001553309653 1.0 14.206845932282862 -6.6212648576149755 4.017209897663781 0.9205084255295864 1.113003524078892 0.8178239731690562 0.041152031385665463 0.090196182050649 2.7184115237129793 0.014606369156155277 0.014611251958167693 2.391856620546499e-07 6.6212648576149755 0.19249509854930558 MITNSLNHDSPPS(ph)TPPR ddPTM_A459_Selumetinib_30min_R2 1 MITNSLNHDSPPSTPPR 17 0 Q8N9M1-2;Q8N9M1;J3QKZ5;J3QS16;Q8N9M1-3 Q8N9M1-2 C19orf47 Uncharacterized protein C19orf47 1 MITNSLNHDS(0.391)PPS(0.545)T(0.064)PPR 98.292 0.0034717 12537000.0 14607.0 15613.0 20354.0 19416.0 20015.0 16510.0 14626.0 15271.0 14260.0 17617.0 True False 13795.201416453958 16810.46689629241 19044.44579975959 16771.507305531806 17500.53676362974 18784.102637142034 15306.137980869176 15315.43608174985 17112.398457690408 17108.35143553696 0.8063431166020459 0.9825883551453245 1.1131666234188429 0.9803111286745332 1.022923618886981 1.0979493090213388 0.8946588476710691 0.8952023308299057 1.0002365524328103 1.0 14.06241312766654 -10.142722875809609 12.024115784277521 1.0000051854260292 0.9813805841675952 0.0038636735993967664 0.08867089008362192 0.0 0.0 0.08878615868740704 0.021533806491825316 7.199082063585217e-11 10.142722875809609 -0.018624601258434015 MIYAS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 MIYASSK 7 0 P60981;P60981-2;F6RFD5;P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;Q9Y281-3;Q9Y281 P60981;P23528;Q9Y281 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 1 MIY(0.001)AS(0.997)S(0.002)K 82.645 0.040774 9545600.0 43776.0 52964.0 52202.0 41750.0 49955.0 40505.0 35394.0 42787.0 38018.0 52883.0 True False 41343.105169212584 57026.16849389816 48843.38015324014 36063.57797723284 43679.20629663373 46084.19608221917 37039.89113188046 42911.50308623082 45622.66231167418 51356.130383464915 0.8050276541575996 1.1104062566259632 0.9510720490141562 0.7022253761713362 0.8505159164152502 0.8973455698106269 0.7212360210029796 0.8355672977270693 0.8883586432821128 1.0 15.648248880940669 -5.550115790724832 24.890672117067115 0.8324502796452001 0.9759725400651728 0.1859584235208661 0.10600370305400454 248.33833389503573 226943.74778564592 0.027269268483184998 0.0472331295411385 2.8176315998165007e-06 5.550115790724832 0.14352226041997262 MIYAS(ph)SKDAIK ddPTM_A459_Selumetinib_30min_R1 2 MIYASSKDAIK 11 1 P60981;P60981-2;F6RFD5;P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;Q9Y281-3;Q9Y281 P60981;P23528;Q9Y281 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 1 MIYAS(0.981)S(0.019)KDAIK;MIYAS(0.971)S(0.029)KDAIK 132.79 0.0092294 25211300.0 1893.31 2672.7 2963.8 4052.3999999999996 2739.8999999999996 2424.75 2464.9 2094.84 927.25 1696.52 True False 1937.4204392600461 2359.779041495479 2561.332238988061 3344.724412969224 2492.076528768633 2400.35921649685 2278.970608497626 2039.2780382006908 1573.4755263395116 1914.2848675042014 1.0120857517857351 1.2327209401033934 1.338009970442625 1.7472448692184435 1.3018315983543989 1.2539195483618801 1.1905075609090998 1.0652949687992115 0.8219651907873937 1.0 10.90258982000069 -7.694729687335873 1.5352433054714698 0.9141063771654324 1.3352416033914751 0.4539114389496489 0.17630417274984364 0.3934075786281492 1.7593188967318938 0.14479080308747624 0.0596538020850164 2.0196230220997895e-08 7.694729687335873 0.4211352262260427 MKDTDSEEEIR ddPTM_A459_Selumetinib_30min_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 107.39 0.029801 60059000.0 7013.2 7462.7 6721.2 7494.9 7031.3 6857.3 7204.7 6866.4 4140.4 5977.7 False True 7176.593914688331 6588.963614684893 5808.49795690889 6186.056411697522 6395.320156476841 6788.3217879302365 6661.243678462755 6684.280766789452 7025.956397148673 6744.9960227287975 1.0639878645599148 0.9768669384654761 0.8611566170440776 0.9171326996861375 0.9481577357386655 1.0064233937359552 0.9875830402295539 0.9909984741674048 1.0416546390054369 1.0 12.71960187713272 -6.759294653240573 23.887718019973907 1.00366001669973 0.9476145325650808 0.20948448391215768 0.04968528107673263 53.74273500874393 598581.6613451146 0.01811637068612304 0.01726462039851231 1.7406255206535768e-07 6.759294653240573 -0.05604548413464927 MKDTDSEEEIR ddPTM_A459_Selumetinib_30min_R2 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 116.84 0.016267 47272000.0 180630.0 170530.0 192620.0 179920.0 190400.0 146070.0 172100.0 183790.0 130280.0 152160.0 False True 170591.30771918118 183609.102659626 180227.03890879898 155414.58562068833 166480.24980240333 166189.8166085607 180102.9910096804 184324.79847192773 156339.64032734247 147766.74544084186 1.1544634566474707 1.2425603752173966 1.2196725208443637 1.0517561658208698 1.1266421907427973 1.1246767066078105 1.2188330362989845 1.2474037911711455 1.0580164018698832 1.0 17.172962105317062 -8.467786832998986 5.514085174065844 1.0004057150135828 1.1710259395794302 0.5041403422302062 0.05855801342165129 0.15966027268176983 10.096912785081924 0.061272408219996605 0.01590792843286207 3.4057531502100418e-09 8.467786832998986 0.17062022456584747 MKDTDSEEEIREAFR ddPTM_A459_Selumetinib_30min_R1 2 MKDTDSEEEIREAFR 15 2 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 ; 78.28699999999998 0.021099 31100000.0 5542.5 4381.8 14957.5 15388.9 10434.5 8474.3 6017.7 5937.6 4344.7 3903.7 False True 5671.629466172365 3868.776818956447 12926.353655666355 12701.517500429893 9490.701317360603 8389.056236048767 5563.780044121936 5780.115559957043 7372.638575667046 4404.777920258028 1.2876084944232844 0.8783137059336281 2.9346209706093744 2.883577272310212 2.1546378703252866 1.9045355720356827 1.2631238497935475 1.3122376802184954 1.6737821313895354 1.0 12.104853567957816 -7.166289876986819 4.076237837819896 1.3378153648054272 2.058664602385526 0.23931386234932628 0.6069138463498343 0.4019362374088322 11.938231963706443 0.27236021991218795 0.20590898716516468 6.818834079313934e-08 7.166289876986819 0.720849237580099 MKEIAEAYLGK ddPTM_A459_Selumetinib_30min_R1 2 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PPY6 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ; 166.04 0.0017410999999999998 21074300.0 11336.6 11030.5 15635.5 16817.7 13788.2 12272.3 11503.900000000001 11377.4 7132.0 7975.400000000001 False True 11600.720722816364 9739.043932059672 13512.284979653767 13880.804402327629 12541.059744504435 12148.851804356862 10636.15156115698 11075.634392996371 12102.483099329615 8999.120276974634 1.2890949743719113 1.0822217763861013 1.501511766014132 1.5424623713323833 1.3935873017046225 1.35000438158841 1.181910146080711 1.2307463454327592 1.3448517996026033 1.0 13.135568260095624 -7.22297200795377 6.779147536163825 1.20860853984242 1.36398241314478 0.25409858227592086 0.14145359405993999 0.37791707723115936 52.64037147345036 0.058663855439699604 0.044723644923954385 5.98450166365208e-08 7.22297200795377 0.15537387330235997 MKEIAEAYLGK ddPTM_A459_Selumetinib_30min_R2 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PPY6 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 138.24 0.0035717 5143500.0 33564.0 36933.0 38951.0 39903.0 37047.0 28072.0 24232.0 24461.0 19053.0 39666.0 False True 31698.64724733762 39765.64234168757 36444.93506664221 34468.14256348557 32392.82465561786 31938.663187756007 25358.836014797074 24532.17746026345 22864.132385299825 38520.73951535502 0.822898200973063 1.032317729150457 0.9461120301731135 0.8947944145710387 0.8409190753647274 0.8291290247692341 0.6583164376864732 0.6368563472278228 0.5935538277032765 1.0 15.233347779638772 -6.795213786568919 1.4986600920785245 0.6944193237247013 0.933372812235814 0.3481349954862043 0.11704701884905298 0.36406485632487784 1.6999769676167515 0.05134708940792926 0.04524435693146032 1.6024563685002689e-07 6.795213786568919 0.23895348851111275 MKETIQGTGSWGPEPPGPGIPPAY(ph)SSPR ddPTM_A459_Selumetinib_30min_R1 1 MKETIQGTGSWGPEPPGPGIPPAYSSPR 28 1 Q9H4L4 Q9H4L4 SENP3 Sentrin-specific protease 3 1 MKETIQGTGSWGPEPPGPGIPPAY(0.548)S(0.226)S(0.226)PR 95.287 1.28e-05 37769000.0 1244.8 1194.5 1378.4 1560.3 1375.1 1097.3 1508.2 1347.8 733.14 1460.6 True False 1273.8014180408413 1054.6473846920162 1191.2208510092266 1287.8228954584629 1250.7224477936238 1086.262158268685 1394.4352597412137 1312.0519657285956 1244.0850335729826 1648.0822374487998 0.7728991849415608 0.6399240042320888 0.722792117979024 0.7814069384377254 0.75889565421791 0.6591067688164629 0.8460956789994735 0.7961083105656349 0.7548682980157609 1.0 10.686572517838206 -14.522878745275712 0.17047559710045151 2.006232837973584 0.6870800010844423 0.6725802978166688 0.054646610491111115 77.0551823738972 0.7252362057005347 26.106358161307213 0.19523400962083676 3.000000000031954e-15 14.522878745275712 -1.3191528368891419 MKFGT(ph)S(ph)HMMVR ddPTM_A459_Selumetinib_30min_R1 1 MKFGTSHMMVR 11 1 H0YIB5 H0YIB5 CFAP54 2 MKFGT(1)S(1)HMMVR 66.663 0.033265 0.0 201.64 311.91 505.77 513.79 373.28 402.37 264.73 310.65 198.21 243.19 True False 206.33781967685994 275.39143219697485 437.0892119957459 424.0662215327846 339.5168899079368 398.32252312272936 244.76120296465427 302.4105528665887 336.3478933143752 274.4058053711989 0.7519440756646498 1.0035918585047523 1.592857014830569 1.5453981411185327 1.2372802734572605 1.4515819830557293 0.8919680202594721 1.102055958537418 1.2257316963807852 1.0 8.100167193485316 -7.261698239381211 24.99873287028317 1.0634435917249778 1.2785039642411828 0.14338830601306052 0.2481541991141183 52.78739908023034 5097418.999603433 0.10808053487989912 0.07804030171308225 5.473961778002861e-08 7.261698239381211 0.21506037251620502 MKPPAACAGDMADAAS(ph)PCSVVNDLR ddPTM_A459_Selumetinib_30min_R1 1 MKPPAACAGDMADAASPCSVVNDLR 25 1 P52888 P52888 THOP1 Thimet oligopeptidase 1 MKPPAACAGDMADAAS(0.957)PCS(0.043)VVNDLR 105.53 1.7757000000000005e-07 17190000.0 1227.3 1611.4 1530.9 1777.7 1620.8 1286.0 1593.4 1213.0 648.49 1035.2 True False 1255.8937020899134 1422.7365388804637 1323.0121886317643 1467.2580665618855 1474.1989261754813 1273.0640075945762 1473.2085551462997 1180.8272996207043 1100.4401661643665 1168.0780037019017 1.075179652480146 1.2180150078774636 1.1326402726862772 1.2561302086948087 1.2620723286487834 1.0898792748086603 1.261224464870814 1.0109147641496519 0.9420947596623036 1.0 10.189920904596015 -7.869465129534716 5.815355502672593 0.9737505460351729 1.1858978174908879 0.6607024802198269 0.06617411836860432 0.11977151053895535 5.645075564078264 0.035810257478145174 0.016908243354812804 1.350625268193981e-08 7.869465129534716 0.212147271455715 MKPPAACAGDMADAAS(ph)PCSVVNDLR ddPTM_A459_Selumetinib_30min_R2 2 MKPPAACAGDMADAASPCSVVNDLR 25 1 P52888 P52888 THOP1 Thimet oligopeptidase 1 MKPPAACAGDMADAAS(0.756)PCS(0.244)VVNDLR;MKPPAACAGDMADAAS(0.702)PCS(0.298)VVNDLR 107.95 1.4182e-07 11994300.0 40107.0 41977.0 45647.6 48784.0 52948.2 45554.2 36397.2 34814.4 28312.8 44092.5 True False 37878.01350104187 45196.500922671294 42710.68311334903 42139.535042906035 46296.37375308623 51828.877550145095 38089.74191968358 34915.70414016582 33976.15112572911 42819.43495892684 0.8845986299766714 1.055513716283846 0.9974602223106838 0.9841216980870258 1.0812000157754191 1.2104054525675145 0.8895433103267228 0.8154172088832462 0.7934749993389599 1.0 15.385978137735911 -7.498053460204534 24.334413738723512 0.8531636790868269 1.0357560056599906 0.4161612094828969 0.09299871778558313 477.6437687377222 468201.0129861433 0.03937847685284019 0.026395455760594634 3.176483032098842e-08 7.498053460204534 0.1825923265731637 MKS(ph)SSSVTTSETQPCTPSSSDYSDLQR ddPTM_A459_Selumetinib_30min_R2 1 MKSSSSVTTSETQPCTPSSSDYSDLQR 27 1 P50552;K7EM16 P50552 VASP Vasodilator-stimulated phosphoprotein 1 MKS(0.247)S(0.247)S(0.247)S(0.247)VT(0.005)T(0.008)S(0.001)ETQPCTPSSSDYSDLQR 166.91 1.1095999999999999e-21 16818000.0 15884.0 13976.0 17055.0 17171.0 15411.0 13244.0 9590.7 9608.3 8014.3 16271.0 True False 15001.23086868999 15047.914260077046 15957.699868079975 14832.280178372826 13474.932403911967 15068.240782938177 10036.686553611518 9636.258562260306 9617.383938251623 15801.213952864966 0.9493720490994346 0.9523264671287274 1.0099034109456277 0.9386797889464398 0.8527783019777911 0.9536128570809023 0.6351845233885803 0.6098429266893843 0.6086484220098713 1.0 13.947747779502512 -7.256858033342466 24.901147741394666 0.6809058735678905 0.941986672463482 0.48988510978733735 0.11272132395457016 268.56737073032383 1459757.8936437636 0.042078034919541325 0.03148716970908161 5.535310235720756e-08 7.256858033342466 0.26108079889559155 MKTPVQYSQQQNS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 MKTPVQYSQQQNSPQK 16 1 P46013 P46013 MKI67 Antigen KI-67 1 MKTPVQYSQQQNS(1)PQK 105.91 0.0019721 14319000.0 3151.7 4333.1 4995.0 6156.8 4095.7 3880.4 4093.3 3400.3 1959.3 2483.4 True False 3225.1284778593526 3825.7786375964592 4316.7064355710145 5081.630457449639 3725.2446581545637 3841.366699121302 3784.539085465265 3310.1129982689895 3324.7889983898676 2802.1685803644737 1.150940204118578 1.3652921042669197 1.5404877728696633 1.8134635057497788 1.3294148982535616 1.3708549607039209 1.350575091015051 1.181268329630064 1.18650570193654 1.0 11.452328036554954 -7.937675869873055 0.8995597961863783 1.026539753773921 1.4563127556643851 0.4388708364873234 0.16153904374721548 0.5642066435071301 0.8588466455090514 0.1603754796056022 0.0635028962883798 1.1543144442218762e-08 7.937675869873055 0.4297730018904642 MLAEDELR ddPTM_A459_Selumetinib_30min_R2 2 MLAEDELR 8 0 P61204-2;P84077;P61204;F5H423 P61204-2 ARF3;ARF1 ADP-ribosylation factor 3;ADP-ribosylation factor 1 0 ; 176.41 0.0021588 14187000.0 84476.0 78124.0 98705.0 93689.0 104257.0 76467.0 81967.0 86456.0 82610.0 87097.0 False True 79781.16210422157 84115.85959174734 92354.42776187834 80928.39657746021 91159.3035905944 86999.63515168634 85778.62791452913 86707.57264643873 99134.30831625537 84582.28330481722 0.9432372712936421 0.9944855625215392 1.0918885628690338 0.9568008029034976 1.0777588406082033 1.0285798840184708 1.014144151268659 1.0251268854254312 1.172045781254162 1.0 16.368067886098167 -4.9878690773795 4.457523415321781 1.0431536980269456 0.9501433558876632 0.25487475679331273 0.05568235881210972 0.25722941122397536 12.946845530230235 0.013599203911639095 0.05445025527768455 1.0283262511242353e-05 4.9878690773795 -0.09301034213928239 MLAESDES(ph)GDEESVSQTDK ddPTM_A459_Selumetinib_30min_R2 1 MLAESDESGDEESVSQTDK 19 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 MLAES(0.023)DES(0.93)GDEES(0.042)VS(0.003)QT(0.002)DK 76.378 0.037864 0.0 8427.6 7117.5 5584.1 9578.0 7094.6 6239.8 8503.0 9718.8 5349.9 5645.9 True False 7959.227730355813 7663.389363630392 5224.825085508379 8273.459877028408 6203.312921471277 7099.2758107352465 8898.406348374858 9747.080098966044 6420.029488695508 5482.88819719011 1.4516487376917127 1.3976920717730033 0.9529329976463893 1.508960164693568 1.1313951148320647 1.2948058678952288 1.6229414185274003 1.7777273123973716 1.1709211017626928 1.0 12.420720340276755 -7.048260723142194 22.014166857681687 1.45787508261051 1.28068368867462 0.01292039212802154 0.2542208243852068 252.65506618790323 115246.85368622866 0.09422131785538237 0.0729882583792515 8.948274060693948e-08 7.048260723142194 -0.17719139393589 MLAESDES(ph)GDEESVSQTDKTELQNTLR ddPTM_A459_Selumetinib_30min_R1 1 MLAESDESGDEESVSQTDKTELQNTLR 27 1 P22059 P22059 OSBP Oxysterol-binding protein 1 1 MLAES(0.233)DES(0.604)GDEES(0.145)VS(0.018)QTDKTELQNTLR 61.807 0.0019316 10235000.0 539.71 434.62 435.46 443.54 494.58 407.66 344.42 464.24 218.48 283.34 True False 552.284192907152 383.7344883506435 376.3269238105614 366.08406527696417 449.84532632519085 403.559310525665 318.4401221058672 451.92684713595736 370.74460285214997 319.7094489653174 1.727456585016556 1.2002600786199211 1.1770904020149433 1.1450523794705785 1.4070442014805475 1.262268950235011 0.9960297486872592 1.413554865514729 1.1596297952781776 1.0 8.320617573161089 -4.760862410668666 24.997851624773524 1.2088697117708416 1.7274571769618776 0.5835410538482065 0.13436119475850888 9.867416055430827 427155.0239572967 0.03206911184436466 0.18478037632237224 1.734353373200436e-05 4.760862410668666 0.518587465191036 MLAQKS(ph)GNIINMS(ph)S(ph)VASSVK ddPTM_A459_Selumetinib_30min_R2 1 MLAQKSGNIINMSSVASSVK 20 1 Q9BUT1-3;Q9BUT1-2;Q9BUT1 Q9BUT1-3 BDH2 3-hydroxybutyrate dehydrogenase type 2 3 MLAQKS(0.999)GNIINMS(0.982)S(0.891)VAS(0.11)S(0.017)VK 41.202 0.046684 8046100.0 19870.0 24094.0 25753.0 15998.0 15263.0 34276.0 17539.0 14380.0 13417.0 18315.0 True False 18765.704945912254 25941.932325579306 24096.08001774633 13819.044801910693 13345.525487048759 38997.2078734513 18354.59825286917 14421.843419262852 16100.7749023024 17786.198361915165 1.0550711604619492 1.4585428430353993 1.3547628069493618 0.776953260090747 0.7503304087524948 2.19255442225104 1.0319573570129015 0.810844629403422 0.905239814303337 1.0 14.118470560165054 -7.513200101490243 24.972766509487016 0.8991054073855157 1.2637393824080423 0.15489315933689185 0.38354012501791446 920.9720465368792 2376303.4783064667 0.1773412704424487 0.1099851102384686 3.067608260048721e-08 7.513200101490243 0.3646339750225266 MLAQSALSPYLSS(ph)PVSSYQR ddPTM_A459_Selumetinib_30min_R2 1 MLAQSALSPYLSSPVSSYQR 20 0 F5H5C8;F8VV01;Q15434 F5H5C8 RBMS2 RNA-binding motif, single-stranded-interacting protein 2 1 MLAQSALSPY(0.003)LS(0.234)S(0.755)PVS(0.005)S(0.001)Y(0.001)QR 102.79 0.00062012 2711000.0 12519.0 10496.0 11312.0 15190.0 15019.0 11021.0 11316.0 11645.0 11233.0 13898.0 True False 11823.244097527695 11301.009450040687 10584.198235574362 13121.095795788433 13132.178948436429 12539.04271132298 11842.216422228605 11678.885022066468 13479.913876243776 13496.728628659403 0.8760081366992758 0.8373147123995475 0.7842047155856363 0.9721686015029347 0.9729897747629839 0.9290431078755751 0.8774138347186183 0.8653122799896217 0.998754160887556 1.0 13.720322145111702 -1.5228787463787947 0.10975214214673193 1.0298688094485882 0.4540583504630903 0.34899833477944875 0.05675353386140686 143.85572554397953 1.1068826541105055 0.5811627247592162 12.539034679014284 0.02999999992412127 1.5228787463787947 -0.5758104589854979 MLAS(ph)PAPEDEEK ddPTM_A459_Selumetinib_30min_R2 3 MLASPAPEDEEK 12 0 Q8TBP0 Q8TBP0 TBC1D16 TBC1 domain family member 16 1 MLAS(1)PAPEDEEK;MLAS(1)PAPEDEEK;MLAS(1)PAPEDEEK 131.32 0.0020419 3800600.0 87501.0 61464.0 71580.0 76930.0 80255.0 65140.0 91050.0 92074.0 56474.0 69201.0 True False 82638.04471425597 66178.09116209038 66974.62073041133 66452.00128834776 70172.64941119688 74112.44371795475 95284.00541215237 92341.92009632869 67770.37801540038 67202.9873242093 1.2296781438536784 0.9847492469765594 0.9966018386549358 0.9888251093327364 1.0441894356966746 1.1028147210244086 1.4178537176103647 1.3740746322903907 1.0084429385326845 1.0 16.03623774502418 -7.015282585335095 22.36371387337386 1.2354183966052033 1.042465488962849 0.1843036711520285 0.1424118526172154 226.31686640750962 331179.3470944883 0.05259162204179034 0.04223867925120079 9.654224965735644e-08 7.015282585335095 -0.19295290764235418 MLDAEDIVGTARPDEK ddPTM_A459_Selumetinib_30min_R2 1 MLDAEDIVGTARPDEK 16 1 P12814-4;P12814-3;P12814;P12814-2;H9KV75;G3V2N5;G3V2W4 P12814-4 ACTN1 Alpha-actinin-1 0 120.92 0.0044122 4434500.0 23909.0 21008.0 26194.0 21875.0 27412.0 18804.0 18890.0 21061.0 16244.0 21469.0 False True 22580.233495310316 22619.246048633257 24508.706557870817 18895.587263520207 23968.259493610713 21394.080314283397 19768.4224298249 21122.284023163753 19493.25389528211 20849.134186839023 1.0830297936095614 1.08490097698693 1.1755263474366189 0.9063008129828245 1.149604548506414 1.026137590298036 0.9481651493376487 1.013101255614593 0.934967069643937 1.0 14.347699852893756 -6.999438883754329 24.99383843130237 0.9768645939830691 1.0770278927168522 0.33812917535479736 0.06974414950304693 23.163655009973883 1031722.5394987849 0.02392367900975911 0.020913721882415463 1.0012928529174288e-07 6.999438883754329 0.10016329873378305 MLDAEDIVNTARPDEK ddPTM_A459_Selumetinib_30min_R2 2 MLDAEDIVNTARPDEK 16 1 O43707 O43707 ACTN4 Alpha-actinin-4 0 ; 127.07 0.0030108 31978000.0 162060.0 131814.0 153010.0 162230.0 166215.0 110815.0 143651.0 132928.0 116210.0 125987.0 False True 153053.35397758108 141923.70995118748 143165.50318469192 140133.9941376405 145333.5857190466 126078.76037158654 150331.0561390564 133314.7984725849 139455.24717869598 122349.42795646247 1.2509527550226427 1.1599867062859537 1.1701362693386417 1.145358801248393 1.1878566834882378 1.0304809959262837 1.2287025664930045 1.0896233901479655 1.139811190848563 1.0 16.90064783056352 -14.52287874116268 0.07065326189735707 0.4899587193893421 1.334852711322546 0.48241933256517144 0.05476031286661205 268.9006806264452 1.3613199699727114 22.41178576175368 2.7251846465603746 3.0000000284437705e-15 14.52287874116268 0.8448939919332038 MLDLY(ph)S(ph)QIS(ph)SVPIGYS(ph)HPALLK ddPTM_A459_Selumetinib_30min_R2 1 MLDLYSQISSVPIGYSHPALLK 22 0 H3BNQ7;H3BRN4;P80404 H3BNQ7 ABAT 4-aminobutyrate aminotransferase, mitochondrial 4 MLDLY(0.998)S(0.999)QIS(0.975)S(0.042)VPIGY(0.176)S(0.809)HPALLK 47.088 0.026736000000000003 3447700.0 8387.9 6592.6 11477.0 12637.0 10708.0 8857.0 7279.1 6627.4 8979.4 11218.0 True False 7921.734097424123 7098.23122144991 10738.582315212781 10915.818799959074 9362.765309265409 10076.971354159125 7617.592573263018 6646.684636774869 10775.530905398678 10894.10719213565 0.7271577154246055 0.6515661261873807 0.9857239446812914 1.0019929680735193 0.8594339255285002 0.9249928586560624 0.699239730150818 0.6101174258293554 0.989115557186497 1.0 13.411260347250918 MLENTDNS(ph)SPSTEHSQGLEK ddPTM_A459_Selumetinib_30min_R2 1 MLENTDNSSPSTEHSQGLEK 20 0 Q96H79 Q96H79 ZC3HAV1L Zinc finger CCCH-type antiviral protein 1-like 1 MLENT(0.196)DNS(0.489)S(0.315)PSTEHSQGLEK 118.37 0.00017129 8754200.0 27600.0 23519.0 26402.0 41418.0 39669.0 24117.0 24771.0 28421.0 23959.0 27285.0 True False 26066.10249155399 25322.83167449572 24703.324064324086 35776.79694996479 34685.42557464045 27438.897837671386 25922.900582805298 28503.70040465016 28751.469470393007 26497.21115505627 0.9837300363053485 0.9556791288830994 0.932299022707155 1.3502099047558733 1.3090217446533683 1.0355390866270626 0.9783256219346925 1.07572454466443 1.0850753047988817 1.0 14.693552902829138 MLENTDNSS(ph)PSTEHSQGLEK ddPTM_A459_Selumetinib_30min_R2 1 MLENTDNSSPSTEHSQGLEK 20 0 Q96H79 Q96H79 ZC3HAV1L Zinc finger CCCH-type antiviral protein 1-like 1 MLENT(0.01)DNS(0.14)S(0.453)PS(0.289)T(0.073)EHS(0.035)QGLEK 54.26300000000001 0.031861 4853700.0 12808.0 11565.0 13028.0 19462.0 16276.0 10651.0 13067.0 12609.0 14038.0 14964.0 True False 12096.182634486358 12451.998312663924 12189.7926638139 16811.242026177373 14231.263370713852 12118.078569848563 13674.641391769292 12645.690102467686 16845.992254492132 14531.950438858788 0.8323853487788447 0.8568704087626791 0.8388270187887579 1.156846914452977 0.9793085539749096 0.8338920932075661 0.9410052318374943 0.8701990937605185 1.1592382127484786 1.0 13.82694073011996 MLFKDDYPS(ph)SPPK ddPTM_A459_Selumetinib_30min_R2 1 MLFKDDYPSSPPK 13 1 H3BPC4;H3BQQ9;B0QYN7;P63279 H3BPC4 UBE2I SUMO-conjugating enzyme UBC9 1 MLFKDDY(0.001)PS(0.499)S(0.499)PPK 66.02199999999999 0.040783 4554300.0 78346.0 61011.0 61484.0 68397.0 60415.0 56537.0 63241.0 60857.0 42764.0 62335.0 True False 73991.84296388722 65690.34751871509 57528.18637871762 59081.210608593916 52825.12758304726 64324.45855821316 66181.83180966413 61034.083794581275 51317.99492599387 60535.226584219614 1.222293978877672 1.0851590259982493 0.9503257792994555 0.9759806635298077 0.8726345066133405 1.0625954867571492 1.0932780059489606 1.0082407754709173 0.847737719369031 1.0 15.885487297615718 -4.912066092265789 2.61603316863915 0.9804310024606212 1.2395937744963608 0.5350648982815789 0.07164595621552095 0.30452641816743825 3.3756746452194983 0.019832586952415653 0.15478554787071044 1.2244298475973541e-05 4.912066092265789 0.25916277203573956 MLGEDS(ph)DEEEEMDTSER ddPTM_A459_Selumetinib_30min_R1 2 MLGEDSDEEEEMDTSER 17 0 A0A087X0M4;Q9BWU0;A0A087WWF4;H7C256 A0A087X0M4 SLC4A1AP Kanadaptin 1 MLGEDS(1)DEEEEMDTSER;MLGEDS(1)DEEEEMDTSER 327.1 4.291399999999999e-120 33065000.0 2960.8 3199.6000000000004 3443.7 3129.1 3252.6 2828.9 3125.4 2739.2 1819.75 2647.55 True False 3029.7808792860897 2824.989344546314 2976.064454890071 2582.6614254816895 2958.402904293171 2800.44383443569 2889.648561726025 2666.547517824431 3087.982840718604 2987.3888318208733 1.0141903347209669 0.9456383161292152 0.9962092725224858 0.8645213498731285 0.9902972364297035 0.9374219400588585 0.9672823741410074 0.8926014214892531 1.0336728877828791 1.0 11.544669312478554 -8.287093155433498 24.98396231299098 1.0168364623796233 0.9508619025370061 0.262065965362939 0.04417632841869796 1123.3655692298385 1094023.6917105368 0.039906183663746216 0.010315846299141408 5.163056107114999e-09 8.287093155433498 -0.06597455984261724 MLGEDS(ph)DEEEEMDTSER ddPTM_A459_Selumetinib_30min_R2 3 MLGEDSDEEEEMDTSER 17 0 A0A087X0M4;Q9BWU0;A0A087WWF4;H7C256 A0A087X0M4 SLC4A1AP Kanadaptin 1 MLGEDS(1)DEEEEMDTSER;MLGEDS(0.978)DEEEEMDT(0.021)S(0.001)ER;MLGEDS(1)DEEEEMDTSER 216.0 1.0913e-11 81917700.0 96498.0 91255.0 97065.0 116782.0 113452.0 86831.0 93545.0 97865.0 89970.0 94884.0 True False 91135.02747210061 98253.96506892769 90819.94357638108 100876.09013981356 99199.14548625128 98791.1820766615 97895.02785590105 98149.77094757716 107966.51397183794 92144.45238176135 0.9890451906374286 1.0663036409598938 0.985625734689998 1.0947603196107387 1.076561235344498 1.0721338021236726 1.0624082657772453 1.0651728716226487 1.1717093235795097 1.0 16.49160968960245 -5.772043061944351 24.999442380763792 1.0793547389101128 1.0189227306739876 0.2988002135141796 0.044562813887670846 255.9068063150411 603330.8672646622 0.011908106429764706 0.01786813220263556 1.6902733263256856e-06 5.772043061944351 -0.060432008236125156 MLGEDS(ph)DEEEEMDTSERK ddPTM_A459_Selumetinib_30min_R1 2 MLGEDSDEEEEMDTSERK 18 1 A0A087X0M4;Q9BWU0;A0A087WWF4;H7C256 A0A087X0M4 SLC4A1AP Kanadaptin 1 MLGEDS(1)DEEEEMDTSERK;MLGEDS(1)DEEEEMDTSERK 174.02 1.2683e-08 16806600.0 2169.54 2858.8 2334.58 2599.04 2293.65 1964.6799999999998 2387.8 2865.3 1449.52 2209.32 True False 2220.086060810033 2524.0903669799372 2017.5568589300053 2145.1664540231795 2086.189762476797 1944.9171029867116 2207.6863235711903 2789.3029361939025 2459.7295712479354 2492.9077425991927 0.8905608590614322 1.0125085352529863 0.8093187021941013 0.8605077586170734 0.836849967139844 0.780180136533602 0.8855868533944941 1.1188953720708805 0.9866909750472095 1.0 11.283613777295967 -7.668974594513481 7.106271761355479 1.038751173136301 0.8651646353719737 0.5707467020530066 0.06656818204062771 0.16021626261225608 10.415546459842378 0.03303628621233172 0.0188752424060053 2.143015960232221e-08 7.668974594513481 -0.1735865377643273 MLGEDS(ph)DEEEEMDTSERK ddPTM_A459_Selumetinib_30min_R2 2 MLGEDSDEEEEMDTSERK 18 1 A0A087X0M4;Q9BWU0;A0A087WWF4;H7C256 A0A087X0M4 SLC4A1AP Kanadaptin 1 MLGEDS(1)DEEEEMDTSERK;MLGEDS(1)DEEEEMDTSERK 122.83 0.0004625 38225000.0 83248.0 80351.0 75992.0 86891.0 83414.0 81531.0 81318.0 90723.0 70415.0 76902.0 True False 78621.40942814808 86513.66333081377 71102.75745383352 75056.29590466456 72934.7875893786 92761.15518527119 85099.44812856015 90986.98890999873 84499.9675594859 74681.63944460833 1.0527541978569164 1.1584328353554865 0.9520781544514796 1.005016714454081 0.9766093531392629 1.2420878260723307 1.139496250503161 1.2183314344281924 1.1314691025517707 1.0 16.18846597814523 -6.753593111730335 24.999234446677654 1.159498848936107 1.0305667471236175 0.3455235021376899 0.07967094036876836 187.0258780009954 595887.8169342395 0.026235239452411168 0.02577892702802431 1.7636276062686018e-07 6.753593111730335 -0.1289321018124896 MLISAVS(ph)PEIR ddPTM_A459_Selumetinib_30min_R1 1 MLISAVSPEIR 11 0 A0AVK6;E9PMT9 A0AVK6 E2F8 Transcription factor E2F8 1 MLIS(0.003)AVS(0.997)PEIR 123.26 0.003915 4405700.0 1607.9 1825.9 1853.5 2538.3 1982.2 1972.2 1579.0 1468.2 1050.0 1465.7 True False 1645.3609415712308 1612.1227791621188 1601.8048805467208 2095.0335547921673 1802.910359985835 1952.3614586143253 1459.8947587398072 1429.2585666142772 1781.7733110342263 1653.8368721270067 0.994874989971124 0.9747773836295963 0.9685386192210316 1.2667715843689804 1.09013796364759 1.1805042513675397 0.8827320174947063 0.864207704340333 1.077357350693651 1.0 10.691601224503982 -7.272155217616849 24.99069399804574 0.9447582441704464 1.0785018167706433 0.25161991962482855 0.10334376671310967 1049.473458888794 2447495.0958435982 0.045558436054850285 0.031087249238060236 5.343733392858526e-08 7.272155217616849 0.13374357260019687 MLISAVS(ph)PEIR ddPTM_A459_Selumetinib_30min_R2 2 MLISAVSPEIR 11 0 A0AVK6;E9PMT9 A0AVK6 E2F8 Transcription factor E2F8 1 MLIS(0.008)AVS(0.992)PEIR;MLIS(0.009)AVS(0.991)PEIR 101.71 0.015002 6364400.0 36401.0 32911.0 37400.0 45913.0 40315.0 29743.0 27657.0 28241.0 29494.0 34496.0 True False 34377.97814474843 35435.16787445589 34993.72471804109 39659.57019565731 35250.26927932715 33839.82826992828 28943.10530130581 28323.176634450774 35393.624131214645 33500.01084862822 1.026207970501483 1.0577658626611135 1.0445884592743062 1.1838673836513494 1.0522465033998818 1.0101438003359327 0.8639730127875762 0.8454676854413786 1.0565257513241662 1.0 15.031873942321639 -6.959269380089807 3.308074992137653 0.9288098414089883 1.076421803276783 0.4322488871604113 0.0699768501379499 0.21513269130908083 4.87010513130602 0.02724968370891367 0.0228190025916439 1.0983243698136464e-07 6.959269380089807 0.14761196186779468 MLLADQGQSWK ddPTM_A459_Selumetinib_30min_R2 1 MLLADQGQSWK 11 0 P09211;A8MX94;A0A087X2E9 P09211 GSTP1 Glutathione S-transferase P 0 147.74 0.031764 0.0 21215.0 18429.0 21390.0 22347.0 24161.0 19716.0 22466.0 21043.0 20468.0 17456.0 False True 20035.955230373846 19842.445041425293 20013.790687671106 19303.30004927478 21125.679177919475 22431.700035971673 23510.713515534455 21104.23164614382 24562.171923703158 16951.999923865198 1.1819228008706526 1.1705076174222309 1.1806153125033636 1.1387034058500318 1.246205714535105 1.3232480024018936 1.3868991045968466 1.2449405227068853 1.448924730652239 1.0 14.04916786589274 -6.486734491309649 3.996215101970777 1.3020224721677052 1.1697660859183092 0.1727107800569816 0.11184295423215912 0.3185603262533683 11.001220211968212 0.03412113541937348 0.037220921714368124 3.260359642432495e-07 6.486734491309649 -0.13225638624939595 MLLS(ph)PGGVSQPLTASLAR ddPTM_A459_Selumetinib_30min_R1 1 MLLSPGGVSQPLTASLAR 18 0 I3L0U5;Q6PK04 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 MLLS(1)PGGVSQPLTASLAR 150.9 0.00013294 18332000.0 2440.4 3450.2 3307.9 3478.5 3229.2 2987.1 2532.1 1993.6 1637.4 2199.6 True False 2497.2565718082187 3046.248980045537 2858.705348994065 2871.045274531992 2937.1194301615656 2957.0524860697956 2341.101658394595 1940.7232518745554 2778.5482090356577 2481.940085918374 1.0061711747099558 1.2273660421252095 1.1518027228833283 1.1567746098389964 1.1833965883486528 1.1914278281119826 0.9432547029145284 0.7819379939449441 1.1195065605330807 1.0 11.277252573864548 -7.2671299286868365 24.331991441702034 0.9430029577239384 1.1577344052591516 0.4906331658238947 0.09486519553212593 245.6407898331174 1050318.786717533 0.037104128935430844 0.025810073888108503 5.40592568667725e-08 7.2671299286868365 0.21473144753521323 MLLS(ph)PGGVSQPLTASLAR ddPTM_A459_Selumetinib_30min_R2 2 MLLSPGGVSQPLTASLAR 18 0 I3L0U5;Q6PK04 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 MLLS(0.991)PGGVS(0.003)QPLT(0.003)AS(0.002)LAR;MLLS(0.979)PGGVSQPLT(0.004)AS(0.016)LAR 140.3 0.00031924 21378000.0 57392.0 58738.0 61210.0 63084.0 74819.0 60947.0 58756.0 54781.0 47273.0 67894.0 True False 54202.38239837924 63243.01572756189 57271.815240409 54491.8503740301 65419.568329653404 69341.89602821901 61488.27042280529 54940.403640517245 56728.92091798024 65933.72381020292 0.8220737320162051 0.9591907156588559 0.8686270383464443 0.8264640190942432 0.9922019347484519 1.0516908801909455 0.9325769404410658 0.8332671122697226 0.8603930983980268 1.0 16.008728943857804 -4.747196884708422 24.638025998085855 0.9211894698701645 0.8220734292572679 0.15053826764044287 0.07281519176906785 1406.5615398882055 2433037.4139090395 0.01961732967215592 0.400866754672011 1.7897942779580913e-05 4.747196884708422 -0.09911604061289658 MLLS(ph)WDGGESR ddPTM_A459_Selumetinib_30min_R1 2 MLLSWDGGESR 11 0 Q658Y4;E7ER68 Q658Y4 FAM91A1 Protein FAM91A1 1 MLLS(0.995)WDGGES(0.005)R;MLLS(1)WDGGESR 116.84 0.005772600000000001 6549900.0 2265.2799999999997 2810.3 3272.2 3090.5 3223.6 2255.0 2746.7 2740.7 1785.52 2394.7 True False 2318.0566165324217 2481.2687695269747 2827.8532129080013 2550.8021908699475 2932.025949172805 2232.3167473761823 2539.5142076191432 2668.0077329517444 3029.8970307788886 2702.0830713533064 0.8578776282297829 0.9182799728967106 1.0465456235924324 0.9440132384947026 1.085098374752903 0.826146601872663 0.9398357269405702 0.9873892336017279 1.1213189790132545 1.0 11.39985631342901 -5.016238531906084 4.878514750196524 0.9870154004596612 0.8682901318039596 0.2374853774743927 0.0784256428099686 0.2553915158733979 17.2645932935018 0.020166970284626034 0.06947072295789684 9.632997955102179e-06 5.016238531906084 -0.11872526865570154 MLLS(ph)WDGGESR ddPTM_A459_Selumetinib_30min_R2 1 MLLSWDGGESR 11 0 Q658Y4;E7ER68 Q658Y4 FAM91A1 Protein FAM91A1 1 MLLS(1)WDGGESR 92.247 0.025884 0.0 8120.2 6402.9 7424.7 9561.7 10958.0 5962.2 7441.5 7048.6 5417.9 8065.1 True False 7668.911791736116 6893.981841431545 6947.002885402136 8259.379965147484 9581.358074237061 6783.43893053715 7787.544495052512 7069.110259041451 6501.6313887742535 7832.239607353649 0.9791467289299749 0.8802056866287417 0.8869752757410065 1.0545361709047811 1.2233229005457358 0.8660918550255043 0.9942934442073026 0.9025656278957938 0.8301114004058182 1.0 12.935209185846444 -10.001146121342202 6.856392456734325 0.9999961448742388 0.9605805362293229 0.012621510997235852 0.10978905303907889 0.0 0.0 0.11223723677749746 0.027221528374181254 9.973644372925366e-11 10.001146121342202 -0.03941560864491589 MLMS(ph)SVK ddPTM_A459_Selumetinib_30min_R2 1 MLMSSVK 7 0 A6QRH7;Q5HY75;D3DWX8;P98173-3;P98173-2;P98173 A6QRH7 FAM3A Protein FAM3A 1 MLMS(1)SVK 103.71 0.046998000000000005 22505000.0 54229.0 59373.0 57505.0 64829.0 74944.0 51303.0 39474.0 51718.0 45010.0 66776.0 True False 51215.169275887 63926.71818571512 53805.19090671 55999.17836373722 65528.8647121393 58369.52256773459 41309.61921624708 51868.49081762416 54013.25768447725 64848.00337511592 0.7897724927571133 0.9857931602909717 0.8297123751902071 0.8635451432453162 1.010499341561604 0.9000974514218072 0.6370222222153843 0.7998471520794366 0.8329209053983567 1.0 15.984774535134166 MLPHAPGVQMQAIPEDAIPEES(ph)GDEDEDDPDKR ddPTM_A459_Selumetinib_30min_R1 2 MLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKR 33 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 MLPHAPGVQMQAIPEDAIPEES(1)GDEDEDDPDKR;MLPHAPGVQMQAIPEDAIPEES(1)GDEDEDDPDKR 94.957 6.701399999999999e-11 61283000.0 4977.0 5404.2 6952.7 6979.0 4914.7 5688.599999999999 5554.3 5711.5 3446.4100000000003 5238.2 True False 5092.954416443823 4771.4737516555815 6008.5615284473615 5760.248662055127 4470.166252760762 5631.377848835542 5135.334679207416 5560.0124664333525 5848.306054172829 5910.573994388811 0.8616683288761475 0.8072775598758036 1.0165783448699863 0.9745667117142269 0.7562998546341698 0.9527632771676112 0.8688385737294946 0.9406890890312407 0.9894649926935868 1.0 12.529082526511138 -8.083037311597897 2.6289206022556457 0.997169975921071 0.8930569618405508 0.24294025958269405 0.07303302881550544 0.45177258508253354 5.694625933245273 0.06200235578812945 0.020211735387927532 8.259669851205972e-09 8.083037311597897 -0.1041130140805202 MLPHAPGVQMQAIPEDAVHEDS(ph)GDEDGEDPDKR ddPTM_A459_Selumetinib_30min_R1 6 MLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKR 33 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR 72.76899999999998 4.8625e-05 109808400.0 18560.86 20924.649999999994 23668.41 25023.74 19957.12 19652.58 19325.969999999998 18398.440000000002 11792.39 18309.29 True False 18993.291924853424 18474.78225039413 20454.369923269933 20653.813562776242 18152.002019715717 19454.89288831494 17868.196523472285 17910.453604644325 20010.824547911325 20659.4657190873 0.9193505864629162 0.8942526637233054 0.9900725508294302 0.9997264132389524 0.878628821603313 0.9416939021003116 0.8648915110599322 0.8669369212242909 0.968603197198043 1.0 14.334515324246608 -6.278266865982937 24.91153227208392 0.9117892730216467 0.9496094253356026 0.06777502958727377 0.05034177003650831 1806.9986241790575 2675087.1582242525 0.015796987622855002 0.01795350837968501 5.269059878733739e-07 6.278266865982937 0.03782015231395586 MLPHAPGVQMQAIPEDAVHEDS(ph)GDEDGEDPDKR ddPTM_A459_Selumetinib_30min_R2 14 MLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKR 33 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR;MLPHAPGVQMQAIPEDAVHEDS(1)GDEDGEDPDKR 87.352 1.5856e-08 344284700.0 678574.0 636757.0 675989.0 630457.0 620182.0 476497.60000000003 522035.4 518518.0 428841.1 590210.0 True False 640861.5736269476 685594.2144035415 632496.603701174 544587.6690010133 542269.192662574 542130.8191854547 546311.0804935212 520026.80153472413 514621.3028214777 573169.1037502559 1.1181020913963762 1.196146494843644 1.1035078470956254 0.9501343764654554 0.9460893637052256 0.9458479454637085 0.9531411880350804 0.9072833796032956 0.8978524827215932 1.0 19.12860131874094 -5.69595861390142 3.282067620604517 0.9380320270238638 1.1566629607616208 0.8922104002553468 0.031602477573162896 0.06579763872618322 1.421764311510909 0.008754592802271905 0.01586535216481109 2.013916156886005e-06 5.69595861390142 0.218630933737757 MLQHIDYR ddPTM_A459_Selumetinib_30min_R1 2 MLQHIDYR 8 0 J3KRY3;S4R3P3;J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3KRY3 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 ; 128.69 0.005993600000000001 26339000.0 10757.4 9323.0 11375.6 10214.7 11220.8 9013.7 8593.8 10299.599999999999 6852.7 9641.3 False True 11008.02648974337 8231.45882585489 9830.856001698026 8430.894398666649 10205.880621193146 8923.03036178478 7945.562747091923 10026.421150184178 11628.531398594518 10878.854769214782 1.011873650606507 0.7566475516474813 0.9036664437802401 0.7749799567620459 0.9381392469797434 0.8202178033514487 0.7303675722904627 0.9216430739159384 1.0689113555869123 1.0 13.409239069801577 -8.036467662477362 5.609801785116093 1.0256482994889016 0.8446959399180523 0.4416041839648416 0.0831315038942502 0.1723842943812891 14.689352106197145 0.052643034146943046 0.020354982179595436 9.194589350733034e-09 8.036467662477362 -0.18095235957084932 MLQHIDYR ddPTM_A459_Selumetinib_30min_R2 3 MLQHIDYR 8 0 J3KRY3;S4R3P3;J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3KRY3 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 ;; 139.97 0.0012695 8679300.0 111611.0 82610.0 99398.0 109581.0 112467.0 94007.0 95718.0 88494.0 77621.7 84878.0 False True 105408.10743423307 88945.92136698354 93002.8408963598 94655.87876223128 98337.8899922632 106955.61093941928 100169.07666161872 88751.50288902968 93148.20893150823 82427.35160047145 1.2788001238369302 1.0790826059547303 1.1283007289515763 1.148355211277829 1.1930249860375322 1.2975742743481222 1.215240750996612 1.0767239413345662 1.1300643187348927 1.0 16.330835521213906 -8.463394312137254 1.2598855229062988 1.007280267687823 1.1834724823572247 0.40349952607048056 0.06822049045489227 0.49985650199523923 1.7308273770561684 0.06851081342267802 0.02125942153687807 3.4403742452392512e-09 8.463394312137254 0.17619221466940171 MLS(ph)PANSLDIAMEK ddPTM_A459_Selumetinib_30min_R1 1 MLSPANSLDIAMEK 14 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 MLS(0.95)PANS(0.05)LDIAMEK 104.44 0.0061858 5403900.0 1400.2 1711.4 1672.1 1621.2 1844.1 1478.9 1600.6 1894.2 889.52 973.91 True False 1432.8219356850784 1511.0284923917247 1445.038004187846 1338.0878536930463 1677.3014806022982 1464.0236087337626 1479.865453349547 1843.9596627712597 1509.4504720296807 1098.9208351867446 1.3038445443994084 1.3750112328473132 1.3149609670857538 1.2176380780565135 1.5263169346655137 1.3322375569346399 1.3466533766265945 1.6779731566904974 1.373575260107952 1.0 10.101871744837137 -6.250886537987376 24.98914316155568 1.4063566503907834 1.3088811993685883 0.025591060681227296 0.16618823585267953 2056.3015064257406 4869322.432954719 0.047321972370783075 0.060468622686383616 5.611945722969493e-07 6.250886537987376 -0.09747545102219513 MLS(ph)PANSLDIAMEK ddPTM_A459_Selumetinib_30min_R2 3 MLSPANSLDIAMEK 14 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 MLS(0.988)PANS(0.012)LDIAMEK;MLS(1)PANSLDIAMEK;MLS(0.993)PANS(0.007)LDIAMEK 147.64 0.00047473 3628700.0 22810.899999999998 22244.4 22938.5 24227.8 24184.0 20803.300000000003 21569.0 18747.4 15636.3 21937.4 True False 21543.16149726772 23950.473952980657 21462.661883550423 20927.931844713818 21145.789712296868 23668.765741445008 22572.001238162673 18801.951830200844 18763.99691472541 21304.01026178967 1.0112256440237914 1.1242237334037346 1.00744703085528 0.9823470598983715 0.9925732034697438 1.1110004853826372 1.0595188868570553 0.8825545800606164 0.8807729945746429 1.0 14.37883740813314 -7.758551575964923 24.999981818322386 0.9112478247459432 1.041638457425348 0.5032814660226407 0.054403096756234094 57.95581610737116 501743.5955626746 0.02761259684464222 0.01503555079840315 1.743606277891877e-08 7.758551575964923 0.13039063267940487 MLS(ph)SSDAITQEFMDLR ddPTM_A459_Selumetinib_30min_R2 1 MLSSSDAITQEFMDLR 16 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;H0Y390;E9PNZ4;A0A5F9ZGX0;E9PLY5;A0A669KBB0 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 MLS(0.745)S(0.237)S(0.018)DAITQEFMDLR 110.6 0.0027679 4602500.0 2760.7 3316.9 2395.2 2714.3 4026.5 2042.5 3491.6 2663.0 3160.1 4367.9 True False 2607.2713459577226 3571.295564485515 2241.0954396965794 2344.6076575713323 3520.655072633283 2323.8358350310505 3653.9663184741466 2670.7488891166167 3792.208300571348 4241.787377832883 0.6146633750628421 0.8419317722403332 0.5283375238014756 0.5527404956278562 0.8299932926935096 0.5478435451939817 0.8614213757081213 0.6296281852960519 0.8940118781976234 1.0 12.050456591378282 -8.52102625383013 0.8201977624078883 1.0055956019921561 0.6620881819942293 0.4344364944665474 0.12317056333036372 0.6459991060111369 0.9719942005048264 0.11381860381749535 0.041427771808033094 3.0128238884217287e-09 8.52102625383013 -0.3435074199979269 MLSAT(ph)PLY(ph)GNVHSWMNS(ph)ERVRMCGAS(ph)ED ddPTM_A459_Selumetinib_30min_R1 1 MLSATPLYGNVHSWMNSERVRMCGASED 28 2 C9JHP3 C9JHP3 BCOR 4 MLS(0.287)AT(0.937)PLY(0.774)GNVHS(0.244)WMNS(0.775)ERVRMCGAS(0.982)ED 46.558 0.033243 0.0 1232.1 1201.0 1791.6 2192.9 1496.7 1135.7 1234.0 1275.3 926.83 1211.5 True False 1260.8055327507393 1060.386361670248 1548.3105605543606 1809.9511808311638 1361.3237492638473 1124.2758891330948 1140.9183865009002 1241.4749012417842 1572.7628170150979 1367.0078260093244 0.9223103984937533 0.7756988230022139 1.1326274298475008 1.3240240080518881 0.9958419574216554 0.8224355908884359 0.8346099889066165 0.9081695639343882 1.1505148596013743 1.0 10.416805786942215 -6.529072698381905 24.86555522647186 0.9282359381689415 1.0432608840531379 0.07177773570951285 0.15746522742989036 401.50821395205736 1611833.5627645128 0.05704248845003616 0.057188809047960316 2.957517353830834e-07 6.529072698381905 0.11502494588419643 MLSST(ph)PPTPIACAPSAVNQAAPHQQNR ddPTM_A459_Selumetinib_30min_R2 2 MLSSTPPTPIACAPSAVNQAAPHQQNR 27 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 MLS(0.027)S(0.146)T(0.805)PPT(0.022)PIACAPSAVNQAAPHQQNR;MLS(0.032)S(0.153)T(0.758)PPT(0.057)PIACAPSAVNQAAPHQQNR 129.29 8.6484e-12 11212300.0 18650.3 14241.1 17873.7 18317.3 22224.0 15756.0 15469.3 14568.4 13652.7 16144.2 True False 17613.790989066278 15333.346577646189 16723.725601413145 15822.452140895024 19432.02243491917 17926.245981272554 16188.653101836437 14610.79163207155 16383.621488310637 15678.074998330918 1.123466432641854 0.9780120696755547 1.066695088726999 1.0092088564813906 1.239439308524031 1.143395855880328 1.0325663771579021 0.9319251013678025 1.0450021121888262 1.0 13.9364608113973 -7.517628531506367 23.259566058625694 0.9895272821468442 1.089582110317044 0.2857509423539587 0.07241404687086703 132.91126392178526 588848.1692596542 0.03507273589915343 0.021062589703823676 3.036487296171705e-08 7.517628531506367 0.10005482817019984 MLTTVGPASSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 MLTTVGPASSSPK 13 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1 A0A0A0MTL4 NAV2 Neuron navigator 2 1 MLTTVGPAS(0.026)S(0.144)S(0.83)PK 145.81 0.0006172 10214000.0 2632.9 3053.6 3241.1 3077.5 2452.1 2701.1 2347.5 2080.0 1621.0 2165.4 True False 2694.2414472684227 2696.0830924198726 2800.9764220879306 2540.072396829725 2230.307987953417 2673.929386402573 2170.4261850169087 2024.8316432078036 2750.7186068442657 2443.3501827821638 1.1026833019082747 1.1034370396100694 1.1463671649794174 1.0395858992006732 0.912807342831979 1.0943701010380167 0.8882992705308883 0.828711192311449 1.125797941788316 1.0 11.254644931221895 -5.988851089387988 4.697900933099196 0.9681825618779761 1.1146050091914295 0.3595086661349395 0.08489462495536956 0.2017631039371271 11.80079624782639 0.024550864890581614 0.035485582749315535 1.0260036614206711e-06 5.988851089387988 0.14642244731345333 MLTTVGPASSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 MLTTVGPASSSPK 13 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1 A0A0A0MTL4 NAV2 Neuron navigator 2 1 MLTTVGPAS(0.001)S(0.011)S(0.987)PK;MLTTVGPAS(0.043)S(0.22)S(0.737)PK 230.06 4.4593e-13 11273200.0 107801.0 103255.0 97731.0 88915.0 84457.0 80021.0 88704.0 80070.0 61990.0 89453.0 True False 101809.85198159462 111174.32648284595 91443.09386146715 76804.62361306984 73846.75660484028 91043.16639168639 92828.91176364147 80302.99044369801 74389.73214531754 86870.25946319399 1.1719759168525379 1.2797743113677396 1.0526398151281062 0.8841302430506858 0.8500809950513429 1.0480360822481534 1.0685925463705113 0.9244014112530831 0.8563314142837997 1.0 16.40657472610841 -5.457415772399991 4.104598037409929 0.9498650708518525 1.2222273678471305 0.6829450988149377 0.07513249570063063 0.13212285731952672 4.3275176592279925 0.021810003641631732 0.04679991854046697 3.4880622547937133e-06 5.457415772399991 0.27236229699527803 MLWGSDPYPHAEPQQAT(ph)TPK ddPTM_A459_Selumetinib_30min_R1 2 MLWGSDPYPHAEPQQATTPK 20 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 MLWGSDPYPHAEPQQAT(0.817)T(0.183)PK;MLWGSDPYPHAEPQQAT(0.5)T(0.5)PK 98.887 0.0011538 36762000.0 3441.7 3975.0 4889.5 4833.799999999999 3386.3 3461.8999999999996 3740.1 3685.2 2594.0 3664.1000000000004 True False 3521.8849136175795 3509.605152072635 4225.532756100995 3989.6675716638615 3080.0097628998246 3427.076429153702 3457.9812458282136 3587.456524783366 4401.828541735984 4134.422926356388 0.8518443749830329 0.8488742478906489 1.022036891572895 0.9649877728353016 0.7449672705869489 0.8289128834175508 0.8363878846994703 0.8677042936062044 1.064677857138156 1.0 12.013470259915154 -8.255112016610521 24.66218777581719 1.032338935119549 0.8714437881595768 0.4387410067561477 0.07311770261737044 386.8294885178544 1507764.398386499 0.057167960869680644 0.020401239307426457 5.557608926104517e-09 8.255112016610521 -0.1608951469599723 MLWGSDPYPHAEPQQATT(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 MLWGSDPYPHAEPQQATTPK 20 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 MLWGSDPYPHAEPQQAT(0.253)T(0.747)PK;MLWGSDPYPHAEPQQAT(0.274)T(0.726)PK;MLWGSDPYPHAEPQQAT(0.076)T(0.924)PK 96.579 0.0013389 17169500.0 54888.0 55134.0 51307.0 53579.0 49054.0 46325.0 45340.0 45759.0 35985.1 53069.0 True False 51837.544694073054 59362.60051624839 48005.963478837846 46281.44777106969 42891.39797167593 52705.84825351942 47448.39983950558 45892.15111418975 43183.12550770234 51536.76008017886 1.0058363120503937 1.15184967824703 0.9314897444882461 0.8980278872607986 0.8322486300059837 1.0226845492716605 0.9206709883525319 0.890474120662466 0.8379092019079146 1.0 15.653314222855231 -5.363284382360543 6.2709984463753825 0.9118375014795745 1.0777712666772732 0.4925004570889723 0.06587711073979688 0.17051478105637546 8.759474427052739 0.016952355244495978 0.03583273816267646 4.332271020625737e-06 5.363284382360543 0.16593376519769865 MMDSS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 MMDSSPVR 8 0 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 MMDS(0.098)S(0.902)PVR 80.455 0.046106 4082300.0 55416.0 44283.0 48342.0 62068.0 66498.0 55001.0 46695.0 60309.0 47298.0 51297.0 True False 52336.20056782451 47679.36370771265 45231.728350789905 53614.23132672784 58143.92674033722 62576.88850063288 48866.41002438716 60484.489205307575 56758.92161653864 49815.92232438777 1.050591821366377 0.9571109292574684 0.9079773341594112 1.0762468870415869 1.1671755540672266 1.2561623991050324 0.980939582051344 1.2141597783023867 1.1393730953517218 1.0 15.604319314352864 -5.953303659739817 5.331686640710544 1.135298620833314 0.9714534102672387 0.3869194731951544 0.08637447513695297 0.18157883231536343 11.824723650801218 0.024108263034770927 0.035835276489438496 1.1135156885073094e-06 5.953303659739817 -0.16384521056607526 MMLS(ph)PDQAADSDHPSSAHSDPES(ph)LGGT(ph)DT(ph)K ddPTM_A459_Selumetinib_30min_R1 1 MMLSPDQAADSDHPSSAHSDPESLGGTDTK 30 0 A6PVY9;Q02577 A6PVY9 NHLH2 Helix-loop-helix protein 2 4 MMLS(0.882)PDQAADS(0.117)DHPS(0.054)S(0.054)AHS(0.099)DPES(0.931)LGGT(0.932)DT(0.93)K 49.155 0.028992 0.0 2757.4 3543.0 3929.9 4009.7 2894.1 3742.8 3974.3 3916.2 2524.7 3266.1 True False 2821.642055033594 3128.1839129039854 3396.2411653954996 3309.4811663909495 2632.3291659948563 3705.1508301904983 3674.515351272715 3812.329654389617 4284.231503207722 3685.3357495080922 0.7656404319227138 0.8488192462034229 0.9215554283890741 0.898013475931654 0.7142711939736324 1.0053767368916253 0.9970639314920434 1.034459249716522 1.1625077861032251 1.0 11.847580345525152 -6.912574544800444 7.085644478195708 1.0444094337044307 0.8399987732886839 0.6909243668002012 0.07055495972452971 0.14043558956761654 9.595346996629853 0.02579107064928862 0.022733009325953134 1.2229971787693417e-07 6.912574544800444 -0.20441066041574685 MNCS(ph)PTSQIDNIGEEEMDASTTHHK ddPTM_A459_Selumetinib_30min_R2 1 MNCSPTSQIDNIGEEEMDASTTHHK 25 0 A0A5K1VW74;Q9Y243-2;Q9Y243;A0A5F9ZGY0;A0A5F9ZHU3 A0A5K1VW74 AKT3 RAC-gamma serine/threonine-protein kinase 1 MNCS(0.333)PT(0.333)S(0.333)QIDNIGEEEMDASTTHHK 75.945 0.00015352 3639200.0 13500.0 17258.0 19618.0 20663.0 23982.0 23848.0 16016.0 20561.0 19289.0 21438.0 True False 12749.724044781842 18581.63310678375 18355.799238463373 17848.663754336816 20969.16675819978 27132.845529410264 16760.77573510192 20620.829105943223 23147.338979690758 20819.029237386716 0.612407230875393 0.8925311980164252 0.8816837244985521 0.8573244962970833 1.007211552426443 1.303271407135796 0.8050699936096443 0.9904798571929777 1.1118356536107301 1.0 14.34561517887556 -4.130917011059193 0.6339032667022811 1.0294943426990846 1.9971333579732108e-16 0.4746367807887403 0.1275743054926853 6.797198083066862 1.1341842947266743 0.05935478334483802 6.114609692427865 7.397466190673338e-05 4.130917011059193 -1.0294943426990844 MNDFHIS(ph)DDEEKNPSK ddPTM_A459_Selumetinib_30min_R2 1 MNDFHISDDEEKNPSK 16 1 A8MSM7;A0A0C4DG83;A2VCS9;E7ETZ8;Q49MG5-2;Q49MG5 A8MSM7 MAP9 Microtubule-associated protein 9 1 MNDFHIS(1)DDEEKNPSK 73.688 0.018717 12791000.0 54600.0 39293.0 49956.0 43548.0 37190.0 27409.0 40851.0 34556.0 27088.0 30379.0 True False 51565.550581117706 42306.64675309155 46741.88534798024 37616.68727550986 32517.859717181618 31184.340955870768 42750.65244472084 34656.55223894622 32506.35690195777 29501.87933587884 1.747873414911776 1.4340322618579806 1.5843697554255431 1.2750607121412147 1.1022301103928278 1.0570289641835053 1.4490823434671651 1.174723543689588 1.1018402092921933 1.0 14.848519239860963 -1.522878752398639 0.3269100556658588 1.1012407999758842 7.576041690900847 0.68237799480181 0.1339416960822992 36.79400494771515 0.5243130870464587 0.13017098317143844 143.47462937796828 0.029999999508285167 1.522878752398639 6.474800890924962 MNGVMFPGNS(ph)PSYTER ddPTM_A459_Selumetinib_30min_R1 7 MNGVMFPGNSPSYTER 16 0 Q9NY27-2;Q9NY27-3;Q9NY27 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 MNGVMFPGNS(0.453)PS(0.453)YT(0.094)ER;MNGVMFPGNS(0.943)PS(0.041)YT(0.015)ER;MNGVMFPGNS(0.659)PS(0.33)YT(0.011)ER;MNGVMFPGNS(0.872)PS(0.125)YT(0.003)ER;MNGVMFPGNS(0.685)PS(0.309)YT(0.006)ER;MNGVMFPGNS(0.63)PS(0.347)YT(0.023)ER;MNGVMFPGNS(0.7)PS(0.3)YTER 155.06 0.00036276 156723200.0 13856.5 15708.199999999999 17611.7 16980.2 15468.699999999999 13237.300000000003 14971.699999999999 13708.5 8015.58 12633.4 True False 14179.32948994451 13869.076641455942 15220.127874143347 14014.926827830423 14069.558816220791 13104.144780506755 13842.372615215168 13344.906048516426 13601.853825199734 14255.019949736854 0.994690259286958 0.9729257966918499 1.0677030216589987 0.9831572931673895 0.986989766821092 0.9192652712316025 0.9710524898613486 0.9361548489984942 0.9541799221018153 1.0 13.799182437861884 -6.397564374034892 2.637992147800573 0.9533727040756286 1.0077654686913244 0.3412309348850151 0.031177201847108284 0.29540762493313605 4.000773568033371 0.01024870618214544 0.011830953932045496 4.003461219505368e-07 6.397564374034892 0.054392764615695866 MNGVMFPGNS(ph)PSYTER ddPTM_A459_Selumetinib_30min_R2 8 MNGVMFPGNSPSYTER 16 0 Q9NY27-2;Q9NY27-3;Q9NY27 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 MNGVMFPGNS(0.698)PS(0.291)YT(0.012)ER;MNGVMFPGNS(0.495)PS(0.495)YT(0.009)ER;MNGVMFPGNS(0.956)PS(0.02)Y(0.018)T(0.007)ER;MNGVMFPGNS(0.966)PS(0.032)YT(0.002)ER;MNGVMFPGNS(0.995)PS(0.005)YTER;MNGVMFPGNS(0.66)PS(0.34)YTER;MNGVMFPGNS(0.495)PS(0.495)Y(0.001)T(0.008)ER;MNGVMFPGNS(0.942)PS(0.057)YTER 182.91 3.3976e-06 110447100.0 207893.0 212131.0 233781.0 250562.0 266382.0 185224.0 177061.0 199278.0 159490.0 229065.0 True False 196339.13932161717 228400.76559132847 218739.78498150705 216435.0233564414 232916.711674705 210736.92470393682 185294.68733971548 199857.86598775102 191392.4565229343 222451.29826765493 0.8826162888264224 1.026745033047706 0.9833153894130923 0.9729546423955922 1.0470458634701156 0.9473396035224605 0.8329674350417485 0.8984342529989673 0.8603791392246657 1.0 17.76312999281494 -7.007225016340379 24.48870435394869 0.8895774029707625 0.9857716137802792 0.32346246699249315 0.0570732024897494 256.6460716281323 869886.0597083049 0.019470971851975553 0.01649553905961371 9.835014026992168e-08 7.007225016340379 0.09619421080951673 MNGVMFPGNSPS(ph)YTER ddPTM_A459_Selumetinib_30min_R1 2 MNGVMFPGNSPSYTER 16 0 Q9NY27-2;Q9NY27-3;Q9NY27 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 MNGVMFPGNS(0.097)PS(0.9)YT(0.003)ER;MNGVMFPGNS(0.104)PS(0.868)YT(0.028)ER 206.13 8.213100000000001e-08 85274000.0 9930.2 11545.0 12868.7 12344.8 12685.599999999999 9731.599999999999 11266.4 10303.099999999999 6361.7 8871.7 True False 10161.554339194377 10193.30603287511 11121.201222709251 10189.01242059581 11538.18971982459 9633.708939585831 10416.566377369321 10029.828318814582 10795.340259815654 10010.469112675963 1.015092721911214 1.018264570635119 1.1109570488187013 1.0178356584401989 1.1526122891897363 0.9623633848874223 1.0405672561517751 1.0019338959963529 1.0784050316029477 1.0 13.28922196318121 MNGVMFPGNSPS(ph)YTER ddPTM_A459_Selumetinib_30min_R2 2 MNGVMFPGNSPSYTER 16 0 Q9NY27-2;Q9NY27-3;Q9NY27 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 MNGVMFPGNS(0.015)PS(0.985)YTER;MNGVMFPGNS(0.011)PS(0.964)YT(0.024)ER 198.67 9.1795e-07 72202000.0 73972.0 66656.0 75860.0 83882.0 87429.0 55076.0 61467.0 64387.0 56094.0 72948.0 True False 69860.93237337796 71768.30086717928 70979.25019012306 72457.12689547907 76445.38739482306 62662.21906985069 64325.337294549856 64574.35551015838 67314.36739731305 70841.80169833408 0.98615408838509 1.0130784246960645 1.001940217336288 1.022801864978301 1.0790999884552732 0.88453734331441 0.9080138527315651 0.911528983764919 0.9502068804511506 1.0 16.11231328373693 -6.769008522359501 24.999999767569893 0.9239002495361334 1.019280238831953 0.5963066320461071 0.03669520496043685 114.65481573293326 378689.2917939501 0.01267636266086893 0.011393996780424121 1.7021251064867788e-07 6.769008522359501 0.0953799892958197 MNIAS(ph)PGTVHK ddPTM_A459_Selumetinib_30min_R2 1 MNIASPGTVHK 11 0 E7EUC4;Q9NRH2 E7EUC4 SNRK SNF-related serine/threonine-protein kinase 1 MNIAS(0.996)PGT(0.004)VHK 86.641 0.021946 6049200.0 55037.0 52019.0 74611.0 65313.0 71710.0 57271.0 62524.0 60458.0 52588.0 60114.0 True False 51978.263870567316 56008.69003255209 69810.60949031475 56417.256728790606 62701.14870446607 65159.56039562462 65431.48988895565 60633.92277063927 63107.0694314883 58378.352625070605 0.8903688016753873 0.9594085395362654 1.1958304123219563 0.9664071388092269 1.0740479284703048 1.1161596287943525 1.120817682355361 1.0386370982417892 1.0810012032505856 1.0 15.833145879646667 -5.0378034245127 8.990436681952405 1.0751000451671515 0.9071881167696761 0.5017455764705456 0.061201681517015535 0.24924982329768336 58.26001003179386 0.014858783210935027 0.04072715832630643 9.166352945092032e-06 5.0378034245127 -0.16791192839747537 MNIASPGT(ph)VHK ddPTM_A459_Selumetinib_30min_R2 1 MNIASPGTVHK 11 0 E7EUC4;Q9NRH2 E7EUC4 SNRK SNF-related serine/threonine-protein kinase 1 MNIAS(0.059)PGT(0.941)VHK 101.72 0.024627 0.0 12937.0 11183.0 14486.0 14285.0 16277.0 12844.0 16898.0 13992.0 13303.0 12686.0 True False 12218.013330914275 12040.70014098752 13553.986531164262 12339.358357000512 14232.137741773731 14613.14441377665 17683.790482751778 14032.714403499709 15963.971716876255 12319.722217813583 0.991744222385774 0.9773515934943229 1.100186050588544 1.001593878404055 1.1552320328452625 1.1861585963883923 1.4354049685618782 1.1390447085900395 1.2958061419431441 1.0 13.588682106402002 -6.472828996684549 2.2348224786874944 1.2348592323692906 1.0182424507330001 0.40333715041567986 0.1095935673716932 0.28356502615146617 2.8173904562825722 0.03742119370610024 0.041627551041243036 3.3664409678953615e-07 6.472828996684549 -0.2166167816362905 MNILGSQS(ph)PLHPSTLSTVIHR ddPTM_A459_Selumetinib_30min_R1 1 MNILGSQSPLHPSTLSTVIHR 21 0 A0A2R8YCL1;Q13322-3;Q13322-2;Q13322-4;Q13322 A0A2R8YCL1 GRB10 Growth factor receptor-bound protein 10 1 MNILGS(0.2)QS(0.8)PLHPSTLSTVIHR 60.621 0.012963999999999998 9614500.0 504.18 773.87 910.49 727.03 928.79 750.4 769.74 631.02 365.57 495.9 True False 515.9264130364971 683.2649406375979 786.8504589635739 600.0678585433357 844.7811084911926 742.8516573086858 711.6778920787702 614.2832997581672 620.345589823602 559.5535954750512 0.9220321649412058 1.221089357950632 1.4062110677629578 1.072404615743535 1.509741185335407 1.327579097544745 1.271867248881795 1.0978095837926864 1.1086437382230374 1.0 9.128132512616977 -7.816051452045629 4.697197113298759 1.0707551471695946 1.2590971411645182 0.21247194462559482 0.15682435506349882 0.33182468466642123 15.009143164587876 0.08981354044345373 0.04250972737890101 1.5273850940623242e-08 7.816051452045629 0.18834199399492357 MNKS(ph)NLNS(ph)LDEWR ddPTM_A459_Selumetinib_30min_R2 1 MNKSNLNSLDEWR 13 1 O75223-4 O75223-4 2 MNKS(1)NLNS(1)LDEWR 112.11 0.044533 0.0 17891.0 15873.0 18130.0 24318.0 20436.0 16608.0 15898.0 17065.0 14406.0 19327.0 True False 16896.68984334755 17090.408060260663 16963.535538451477 21005.84644911015 17868.646979841993 18895.601247586626 16637.288501289357 17114.65632473717 17287.60253727125 18768.979292423406 0.9002455370691547 0.9105667278965808 0.9038070357560284 1.119178945313756 0.9520308324414394 1.0067463420993987 0.886424788587488 0.9118586609366633 0.921073131784521 1.0 14.196062574214807 MNS(ph)LTFK ddPTM_A459_Selumetinib_30min_R1 2 MNSLTFK 7 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 MNS(0.8)LT(0.2)FK;MNS(0.954)LT(0.046)FK 113.44 0.014134 62372000.0 8826.0 11458.400000000001 8593.3 9825.8 7952.1 8577.3 9368.599999999999 8649.5 4952.1 8199.3 True False 9031.628627593569 10116.845201134356 7426.377059618099 8109.908483109515 7232.833959057288 8491.020149565284 8661.918959296869 8420.087162464375 8403.352012926274 9251.760022945326 0.9762065385606838 1.093504930526033 0.8026988422959429 0.8765800737368998 0.7817792442863961 0.9177734969894022 0.936245529263017 0.9101065247673615 0.9082976635888835 1.0 13.175512129732947 -5.255475726139278 24.972702620894804 0.8865331779774842 1.0348557372125708 0.43494438295158544 0.06506266688152784 412.8076108260253 1728612.7624203553 0.01655859698190352 0.041407689703225455 5.552956531866112e-06 5.255475726139278 0.14832255923508664 MNS(ph)TGGQTPR ddPTM_A459_Selumetinib_30min_R1 3 MNSTGGQTPR 10 0 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 MNS(0.931)T(0.068)GGQTPR;MNS(0.932)T(0.066)GGQT(0.002)PR;MNS(0.91)T(0.089)GGQT(0.001)PR 122.46 0.0044583 28242400.0 6506.5 7877.9 7410.599999999999 7947.1 7588.9 6477.599999999999 8036.599999999999 7637.700000000001 5265.0 5979.2 True False 6658.088790554896 6955.551805663652 6404.281223512021 6559.288170542814 6902.485334929119 6412.441225190225 7430.392791696224 7435.123385253967 8934.320459614473 6746.688562340033 0.9868676653788794 1.0309578901402818 0.9492480887973209 0.9722233522318955 1.0230923320603151 0.9504575712868125 1.1013392308002214 1.1020404034590796 1.3242526873829312 1.0 12.71996385098425 -7.529924325481476 2.3166331525021415 1.163474392560633 0.9870022255686082 0.44750775197456216 0.07932261542034519 0.2531509339641392 2.7062083128267838 0.042062535924735786 0.02224515642331061 2.951723510879377e-08 7.529924325481476 -0.17647216699202484 MNS(ph)TGGQTPR ddPTM_A459_Selumetinib_30min_R2 2 MNSTGGQTPR 10 0 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 MNS(0.769)T(0.228)GGQT(0.003)PR;MNS(0.93)T(0.07)GGQTPR 129.76 0.0028936 36107000.0 87941.0 81249.0 94335.0 100558.0 120176.0 72887.0 84522.0 111223.0 81953.0 117051.0 True False 83053.59127571553 87480.53704328854 88265.58880418217 86861.82692777445 105078.41649292881 82926.52264769054 88452.4404771657 111546.64051604123 98345.88995814191 113671.43349497832 0.7306461150539163 0.769591218774884 0.7764975428772216 0.7641482495389816 0.9244047801822687 0.7295282561150599 0.7781413303024218 0.981307590538735 0.8651768252969779 1.0 16.79451021386277 -8.058844566750034 0.3254748461033476 1.0228513606315044 0.7354015874246774 0.5549738254708712 0.06516100201389402 1.0996455978768491 0.394714543678841 0.11641999905599726 0.09633699607177523 8.732838592597621e-09 8.058844566750034 -0.28744977320682696 MNST(ph)GGQTPR ddPTM_A459_Selumetinib_30min_R2 2 MNSTGGQTPR 10 0 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 MNS(0.301)T(0.699)GGQTPR;MNS(0.268)T(0.732)GGQTPR 143.55 0.002521 36850000.0 102372.0 89208.0 107822.0 131726.0 125095.0 94595.0 96533.0 122775.0 108362.0 130573.0 True False 96682.57406758564 96049.96675107004 100884.84990771751 113784.6915599753 109379.44773651063 107624.60260208673 101021.9757765107 123132.25492350457 130037.42788725435 126803.01822060351 0.7624627191395688 0.7574738211985511 0.7956029069608163 0.8973342524230788 0.862593408827379 0.8487542655715699 0.7966843155165231 0.9710514517035171 1.0255073555191236 1.0 16.95222955997781 -7.253642085500533 0.35995838577252787 1.0324238097888165 0.7451979870671305 0.7035924020646156 0.05097167948507603 0.8953882422226788 0.28830362313292757 0.06916173109745462 0.09171477351071146 5.576451309070536e-08 7.253642085500533 -0.28722582272168606 MNSTGGQT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 MNSTGGQTPR 10 0 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 MNSTGGQT(1)PR 111.94 0.019983 58629000.0 22240.0 17522.0 17621.0 20274.0 26006.0 17486.0 23417.0 26917.0 20370.0 23082.0 True False 21003.98983377395 18865.881057889954 16487.284044294174 17512.646225399254 22738.893783410185 19894.537777896163 24505.936899905217 26995.32401365077 24444.569185354387 22415.562685761724 0.9370271060434098 0.8416420913615292 0.735528448490246 0.7812717651082307 1.014424402464536 0.8875323834959135 1.0932554869778617 1.2043116825614237 1.0905177589354684 1.0 14.452213094586904 -6.958230150771476 1.3220363076411732 1.117662504870352 0.8296799565342979 0.6312670194820016 0.08612029971480266 0.2690069296167134 0.9657184349460406 0.04688691566355323 0.035451238752976934 1.1009557125378125e-07 6.958230150771476 -0.28798254833605397 MNYMQNHQAGAPAPSLS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 MNYMQNHQAGAPAPSLSR 18 0 Q9HCK8-2;Q9HCK8;H0YJG4;A0A2R8Y840 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 MNYMQNHQAGAPAPS(0.003)LS(0.997)R;MNYMQNHQAGAPAPS(0.013)LS(0.987)R 164.46 1.528e-06 40671000.0 150494.0 116085.0 135746.0 134587.0 156531.0 116964.0 112772.0 131832.0 104940.0 135986.0 True False 142130.14595521457 124988.34622789355 127012.25014906997 116256.0184244751 136866.1763751051 133074.72930652212 118016.12145347882 132215.60929403748 125930.93226858576 132059.73084594042 1.0762565169924676 0.9464531347084428 0.9617788052077829 0.8803290577662787 1.036395996708276 1.0076859043561568 0.8936571405794796 1.0011803632121508 0.9535907082492509 1.0 17.0108310851122 -10.60115604594036 4.190851680454514 1.0000022683300367 0.97057244961314 0.01794245800993377 0.057291707918198403 10725509.259066546 27131191.389067948 185.26625864679005 0.013526782086629626 2.505208947035668e-11 10.60115604594036 -0.02942981871689665 MPAMPS(ph)S(ph)GPGDT(ph)SS(ph)SAAEREEDR ddPTM_A459_Selumetinib_30min_R2 1 MPAMPSSGPGDTSSSAAEREEDR 23 1 F8WE91;Q9Y6K1-3;Q9Y6K1 F8WE91 DNMT3A DNA (cytosine-5)-methyltransferase 3A 4 MPAMPS(0.913)S(0.913)GPGDT(0.913)S(0.275)S(0.493)S(0.493)AAEREEDR 54.637 0.030465 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MPCES(ph)SPPESADTPTSTR ddPTM_A459_Selumetinib_30min_R1 2 MPCESSPPESADTPTSTR 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 MPCES(0.631)S(0.369)PPESADTPTSTR;MPCES(0.909)S(0.09)PPES(0.001)ADTPTSTR 226.39 1.2638e-18 9120800.0 995.42 2490.8999999999996 1376.04 1634.71 1220.4099999999999 1156.1 1146.23 1131.54 465.95000000000005 891.11 True False 1018.6113492498515 2199.2642700120055 1189.1813260466743 1349.238585807156 1110.0241309808862 1144.4706836548137 1059.768948264932 1101.5278834400763 790.6831183584736 1005.4926486464457 1.013047037808845 2.187250471669353 1.1826852515008468 1.341868175389892 1.1039604640323892 1.1382188474430466 1.0539798075018758 1.0955106284694467 0.7863638977598294 1.0 9.973686818518095 -6.014386758761277 1.111998245713228 1.0103560120596249 1.579657092300357 0.32499450370608285 0.29456775251160777 0.5578073417251693 1.4053155880098822 0.11098446849343081 0.22023218273389336 9.674159451403857e-07 6.014386758761277 0.5693010802407321 MPCESS(ph)PPESADTPT(ph)STR ddPTM_A459_Selumetinib_30min_R2 1 MPCESSPPESADTPTSTR 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 2 MPCES(0.116)S(0.884)PPESADT(0.292)PT(0.59)S(0.107)T(0.011)R 146.88 0.0010637 0.0 21711.0 19972.0 25482.0 22209.0 26229.0 15554.0 14809.0 15794.0 14473.0 19726.0 True False 20504.389536019164 21503.78817989831 23842.51586270384 19184.095887338077 22933.878529764894 17696.422314845986 15497.647843476796 15839.957925162546 17368.004409407666 19156.459125696907 1.0703642777340887 1.1225345998860845 1.244620193442793 1.0014426863263106 1.1971877672842406 0.9237835760110596 0.8090037799672436 0.8268729529412076 0.9066395984480154 1.0 14.225543297936374 -6.872636612294005 5.28510652095766 0.8709301156627303 1.1258059714794786 0.6874809245039153 0.07878573974366478 0.11204623517221214 4.762522980764005 0.02715228867201016 0.023966671079873388 1.3407981056914295e-07 6.872636612294005 0.2548758558167483 MPCESS(ph)PPESADTPTSTR ddPTM_A459_Selumetinib_30min_R1 2 MPCESSPPESADTPTSTR 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 MPCES(0.029)S(0.918)PPES(0.029)ADT(0.001)PT(0.018)S(0.005)T(0.001)R;MPCES(0.024)S(0.877)PPES(0.099)ADTPTSTR 203.05 9.2705e-11 50362000.0 864.78 2625.0 1268.54 1367.3000000000002 1852.93 1117.1299999999999 1770.07 1055.01 357.03 1002.3199999999999 True False 884.9276914310407 2317.6637796706073 1096.2792355914416 1128.5267223997682 1685.3328086613608 1105.8926864728837 1636.5521948084663 1027.027707644551 605.8538335605234 1130.9775354235792 0.7824449767692453 2.0492571311795196 0.9693200804212772 0.9978330135240988 1.490155865943139 0.977820205826369 1.447024493015714 0.9080885123504274 0.5356904222979249 1.0 10.143354558061553 -7.9324358649388165 5.739170137570994 0.7523341442694101 1.253171096304803 0.23801164218395243 0.3577704383347408 0.25209963340987224 15.178002216151546 0.19281405808428817 0.08986067384793528 1.1683262513790076e-08 7.9324358649388165 0.5008369520353929 MPCESS(ph)PPESADTPTSTR ddPTM_A459_Selumetinib_30min_R2 2 MPCESSPPESADTPTSTR 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 MPCES(0.152)S(0.844)PPES(0.003)ADTPTSTR;MPCES(0.018)S(0.982)PPESADTPTSTR 308.04 2.4024999999999993e-111 59492000.0 88950.0 114825.0 126146.0 55803.0 75579.0 50564.0 65476.0 62593.0 56593.0 107423.0 True False 84006.51509506263 123631.70827943241 118029.9036973802 48202.53513445567 66084.09033516722 57528.732025708676 68520.76373823256 62775.135267171 67913.18134053807 104321.41887152704 0.8052662243648887 1.1851037842160315 1.1314062344448679 0.46205789430277605 0.6334661764574971 0.5514565718911083 0.6568235409318639 0.6017473299944209 0.6509994023775106 1.0 16.670675871290555 -5.753864086237116 24.999818027840924 0.6297144255097838 1.0550433412054088 0.5493464419105647 0.1607682888425085 111.79645305887237 368944.0550847568 0.04124147390641578 0.06970155278056539 1.7625275484015458e-06 5.753864086237116 0.4253289156956249 MPCESSPPES(ph)ADTPTSTR ddPTM_A459_Selumetinib_30min_R2 1 MPCESSPPESADTPTSTR 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 MPCESSPPES(0.878)ADT(0.12)PT(0.002)STR 132.56 0.00047778 4126400.0 28740.0 26712.0 29541.0 27719.0 30018.0 21763.0 23521.0 28069.0 22794.0 24250.0 True False 27142.745855335586 28760.724507382525 27640.36422180888 23943.624382057904 26246.870475675136 24760.655705155812 24614.773105977318 28150.676142926906 27353.436917573297 23549.83949093326 1.152566065929477 1.2212705109287674 1.1736965015175784 1.0167213407665157 1.1145243892545527 1.0514150516689813 1.0452204192497387 1.1953659452228953 1.1615126688275064 1.0 14.523429606418347 -5.60428300066344 8.98187069424568 1.0901391852247977 1.189530029595398 0.3602055084387915 0.0601431208397472 0.3204464129629902 31.913891407113915 0.016809512034757022 0.029162618671994087 2.487236024752004e-06 5.60428300066344 0.09939084437060042 MPCESSPPESADT(ph)PTSTR ddPTM_A459_Selumetinib_30min_R1 1 MPCESSPPESADTPTSTR 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 MPCESSPPESADT(0.999)PTSTR 281.49 1.1024999999999991e-130 0.0 195.52 232.65 149.53 262.43 238.69 151.44 296.55 265.38 0.0 193.52 True False 200.07523558430702 205.4112298439493 129.2246473094962 216.60152692121036 217.10053164414217 149.91665109651836 274.1809947462253 258.3412603242726 0.0 218.360177044428 0.9162624719048442 0.9406991358234514 0.5917958533400707 0.9919461041522245 0.9942313410012048 0.6865567390798369 1.2556364372723505 1.1830969539455445 0.0 1.0 7.770565961696069 -8.238316131212022 24.998455518076145 0.4999995837012054 0.9380513493666488 0.2711806291690967 0.29164926133659713 876.7127567035355 947814.0058224975 0.18869004435985132 0.0712210056429045 5.776753934191953e-09 8.238316131212022 0.4380517656654434 MPCQSLQPEPINT(ph)PTHTK ddPTM_A459_Selumetinib_30min_R2 2 MPCQSLQPEPINTPTHTK 18 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 MPCQSLQPEPINT(0.966)PT(0.031)HT(0.003)K;MPCQSLQPEPINT(0.961)PT(0.035)HT(0.004)K 144.95 0.00038036 27179000.0 58362.0 68263.0 62444.0 66650.0 61868.0 45431.0 52869.0 52012.0 49664.0 62345.0 True False 55118.47368159688 73498.55259985973 58426.42102388657 57572.155022336934 54095.58873306248 51688.70786844339 55327.51325793604 52163.34630894985 59598.18772810209 60544.93785823653 0.910372949934386 1.2139504176542975 0.9650091831077541 0.9508995641739654 0.8934783096107072 0.8537246828045371 0.9138255850139466 0.8615641233473254 0.9843628523931891 1.0 15.885718721267304 -5.5030725167425425 16.411500003596014 0.9158468899508491 1.0689936530809327 0.3111290159397839 0.08154023004604977 8.850141985418992 7330.470846513559 0.020134503052585177 0.04034550672472023 3.1399843481673843e-06 5.5030725167425425 0.15314676313008369 MPDEPEEPVVAVSS(ph)PAVPPPTK ddPTM_A459_Selumetinib_30min_R1 2 MPDEPEEPVVAVSSPAVPPPTK 22 0 O60885;O60885-2;O60885-3;M0QZD9 O60885 BRD4 Bromodomain-containing protein 4 1 MPDEPEEPVVAVS(0.13)S(0.87)PAVPPPTK;MPDEPEEPVVAVS(0.171)S(0.588)PAVPPPT(0.241)K 158.91 2.9854000000000005e-09 33138000.0 7880.7 9543.3 11654.1 11302.900000000001 10536.5 9405.2 10071.3 9792.400000000001 4523.8 8400.9 True False 8064.304976827172 8425.965999440195 10071.537231389017 9329.060696710554 9583.475435370161 9310.59222723834 9311.61373254985 9532.67374180197 7676.558194720607 9479.237346695616 0.8507335223163626 0.8888864885715113 1.0624839175379306 0.9841573067017452 1.0109964636248803 0.9822089991748055 0.9823167615689886 1.0056372040441608 0.8098286722820156 1.0 13.210555276232837 -5.068332731667847 7.2427082753667165 0.9812991770511296 0.8597538755175712 0.3446116751187587 0.06157833153302474 0.24175969567622843 22.374408493960672 0.015318997301404269 0.041729965446716324 8.544118604139274e-06 5.068332731667847 -0.12154530153355836 MPDEPEEPVVAVSS(ph)PAVPPPTK ddPTM_A459_Selumetinib_30min_R2 3 MPDEPEEPVVAVSSPAVPPPTK 22 0 O60885;O60885-2;O60885-3;M0QZD9 O60885 BRD4 Bromodomain-containing protein 4 1 MPDEPEEPVVAVS(0.244)S(0.751)PAVPPPT(0.005)K;MPDEPEEPVVAVS(0.158)S(0.842)PAVPPPTK;MPDEPEEPVVAVS(0.2)S(0.8)PAVPPPT(0.001)K 94.632 0.00015117 10719000.0 124463.0 118197.0 132141.0 141407.0 145070.0 101709.0 105017.0 120946.0 96329.0 120060.0 True False 117545.84472486553 127262.32983674374 123639.19192424227 122147.1226593189 126845.00965774502 115718.49152762438 109900.49858723767 121297.93283631188 115597.491657143 116593.55584665775 1.0081675944377253 1.0915039764643375 1.0604290350905057 1.0476318504254654 1.0879247033564174 0.9924947454198564 0.9425949640971351 1.040348516309437 0.9914569533257501 1.0 16.831128527083393 -6.776502145438456 24.709215661181396 0.9927267876603343 1.0603631268422058 0.5332657762950036 0.030743215814667015 161.39904638974133 264760.1619919714 0.01060809320143863 0.009394032674620169 1.6730073716304584e-07 6.776502145438456 0.06763633918187151 MPEANQLHLPNLNS(ph)QVDSPSSEKSPVMTPFK ddPTM_A459_Selumetinib_30min_R1 3 MPEANQLHLPNLNSQVDSPSSEKSPVMTPFK 31 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;H0Y8P3;G5EA03;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;E9PDJ9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 MPEANQLHLPNLNS(0.233)QVDS(0.233)PS(0.178)S(0.178)EKS(0.178)PVMT(0.001)PFK;MPEANQLHLPNLNS(0.735)QVDS(0.079)PS(0.079)S(0.079)EKS(0.025)PVMT(0.002)PFK;MPEANQLHLPNLNS(0.891)QVDS(0.034)PS(0.028)S(0.034)EKS(0.011)PVMT(0.002)PFK 71.882 5.3625e-05 103666000.0 4812.799999999999 6252.6 4932.1 5637.299999999999 5026.6 5391.299999999999 6235.2 5933.4 3054.4799999999996 4696.0 True False 4924.9288759214 5520.542685245122 4262.347910086044 4652.851380226875 4571.944917518312 5337.06841690874 5764.87384401168 5776.0269576005685 5183.22946960745 5298.77734291357 0.929446277358277 1.041852172299358 0.8044021543547936 0.8780990555206973 0.86283016281722 1.0072263980003575 1.0879630282486685 1.0900678748702772 0.9781934839249944 1.0 12.371443790600921 -6.9072358886275 5.096689519042125 1.0467440915986115 0.9047106732716734 0.49816949528244114 0.06523666484808396 0.18010554876039064 7.7307469653427825 0.024555956344812536 0.021563517744062545 1.2381239123577852e-07 6.9072358886275 -0.14203341832693805 MPEANQLHLPNLNSQVDSPS(ph)SEKSPVMTPFK ddPTM_A459_Selumetinib_30min_R1 1 MPEANQLHLPNLNSQVDSPSSEKSPVMTPFK 31 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;H0Y8P3;G5EA03;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;E9PDJ9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 MPEANQLHLPNLNS(0.022)QVDS(0.018)PS(0.319)S(0.319)EKS(0.319)PVMT(0.002)PFK 80.984 5.3691e-06 73441000.0 2165.1 2981.5 2410.5 2602.2 2407.9 2512.6 2750.0 2750.8 1631.3 1996.7 True False 2215.5426174487666 2632.424593938255 2083.1673399287147 2147.774619343725 2190.105870149273 2487.325525258268 2542.5652859622965 2677.8398481423196 2768.1969545620314 2252.99589450501 0.9833762337749524 1.168410737169411 0.9246210101889214 0.9532971740348413 0.9720860457362023 1.1040080149834188 1.1285263733340738 1.1885684544181778 1.2286737678100443 1.0 11.137628969303933 -6.932307008517394 3.621314188796823 1.149382243071762 1.0031490826221494 0.37983458573892914 0.08259928112406172 0.24448627593595706 6.466421806688331 0.03158258220821353 0.027050732840654165 1.1686729485673349e-07 6.932307008517394 -0.14623316044961254 MPEANQLHLPNLNSQVDSPSSEKS(ph)PVMTPFK ddPTM_A459_Selumetinib_30min_R2 2 MPEANQLHLPNLNSQVDSPSSEKSPVMTPFK 31 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;H0Y8P3;G5EA03;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;E9PDJ9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 MPEANQLHLPNLNS(0.165)QVDS(0.061)PS(0.235)S(0.235)EKS(0.299)PVMT(0.004)PFK;MPEANQLHLPNLNS(0.017)QVDS(0.017)PS(0.289)S(0.289)EKS(0.385)PVMT(0.002)PFK 78.752 8.5963e-06 35708000.0 67777.0 66853.0 65669.0 77919.0 75928.0 56966.0 81328.0 93181.0 82171.0 97140.0 True False 64010.225672828084 71980.41013372436 61443.92803500115 67306.29778222773 66389.24583506763 64812.54941413891 85109.9131483748 93452.14128305492 98607.4960495708 94335.31579996919 0.6785393691643209 0.7630271815313928 0.6513353722723343 0.7134793286211665 0.7037581341842427 0.6870443890978111 0.9022062673627325 0.9906379227182853 1.0452871781195967 1.0 16.525510345480214 -7.450772278383955 2.4218101980251348 1.015670451681778 0.6994195687377761 0.954132591781391 0.03124574050258231 0.056255604033163584 0.6483848191356296 0.01618766032430692 0.009246713414613547 3.541830076950316e-08 7.450772278383955 -0.31625088294400194 MPETVPQEEMPGPPLNS(ph)ESGEEAPTGR ddPTM_A459_Selumetinib_30min_R2 1 MPETVPQEEMPGPPLNSESGEEAPTGR 27 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 MPETVPQEEMPGPPLNS(0.603)ES(0.397)GEEAPT(0.001)GR 116.0 5.5817e-12 5226800.0 11423.0 14486.0 14236.0 15126.0 16925.0 14173.0 11055.0 11425.0 11400.0 15159.0 True False 10788.155389892076 15597.029620168576 13320.071258984844 13065.812706194587 14798.730188580239 16125.202100315817 11569.079405066921 11458.244858489426 13680.31854261365 14721.32028218793 0.7328252618038078 1.059485788040371 0.9048149896651235 0.8875435392845555 1.0052583535245796 1.095363852644828 0.7858724070465973 0.7783435615046931 0.9292861156730732 1.0 13.845619444908241 -8.550835294936771 22.180201515475282 1.000000006618391 0.9123278785732133 0.05543104745224425 0.11429276932495396 7320.140170446913 5807656.814349302 0.112569838654708 0.02906540739520524 2.8129674387849894e-09 8.550835294936771 -0.08767212804517766 MPETVPQEEMPGPPLNSES(ph)GEEAPTGR ddPTM_A459_Selumetinib_30min_R1 2 MPETVPQEEMPGPPLNSESGEEAPTGR 27 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 MPETVPQEEMPGPPLNS(0.345)ES(0.654)GEEAPT(0.001)GR;MPETVPQEEMPGPPLNS(0.081)ES(0.919)GEEAPTGR 163.55 9.185399999999999e-18 24734000.0 3329.3 4720.4 5100.5 5731.5 4598.1 3920.3999999999996 4500.4 3473.0 2199.3 3101.2 True False 3406.86621230991 4167.733373545579 4407.880115041031 4730.601118579876 4182.202666860491 3880.9643354383966 4160.931204707175 3380.8847581061086 3732.0514694834037 3499.269228246075 0.9735936248659325 1.1910296412472827 1.2596573248667624 1.3518825817672158 1.1951645883951376 1.1090785196266928 1.1890857585692949 0.9661688019931797 1.066523101268777 1.0 11.772837952187293 -7.75206972380498 24.719069936542155 1.0122594635878042 1.1890495991943417 0.40351552833562954 0.09464522946341293 170.49806754871264 449812.3600486661 0.04813464317777464 0.027295271733824015 1.7698247989961634e-08 7.75206972380498 0.17679013560653756 MPETVPQEEMPGPPLNSES(ph)GEEAPTGR ddPTM_A459_Selumetinib_30min_R2 1 MPETVPQEEMPGPPLNSESGEEAPTGR 27 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 MPETVPQEEMPGPPLNS(0.027)ES(0.973)GEEAPT(0.001)GR 134.17 3.3772e-12 4347600.0 34455.0 37077.0 39351.0 39314.0 42602.0 33140.0 28962.0 33510.0 28364.0 42123.0 True False 32540.129034293223 39920.68667865457 36819.199502129275 33959.36537956722 37249.95589328773 37704.73418503253 30308.790387114255 33607.50855212088 34037.592556376636 40906.799541302345 0.7954699316292991 0.9758936686882062 0.9000752910272057 0.8301643188995875 0.9106054815087059 0.9217229068962781 0.7409230427942033 0.8215628924523516 0.8320766458889046 1.0 15.320053047880025 -7.158653476542807 18.953597302452405 0.8333366636908749 0.891751361204334 0.04800523681165003 0.0761095692493587 11.303378259191186 2071.9073530905052 0.02773740643954828 0.02148534766035317 6.93979311083098e-08 7.158653476542807 0.05841469751345907 MPFLSIS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MPFLS(0.003)IS(0.498)S(0.498)PK;MPFLS(0.003)IS(0.941)S(0.056)PK 174.57 7.9616e-05 15737000.0 244647.0 226365.0 192767.0 195560.0 203163.0 169377.0 261247.0 192187.0 151852.0 180912.0 True False 231050.49913953687 243726.46762180483 180364.5810888403 168924.39064018344 177639.84763973588 192707.14429867995 273395.5031511095 192746.23235172947 182226.64309938336 175688.60049417443 1.3151137779550937 1.3872639826161426 1.0266151621762216 0.9614988688226515 1.0111062820244057 1.0968676610584636 1.556136837461887 1.0970901459148492 1.0372138123180379 1.0 17.42266105995465 -1.5228787455217419 0.017392600727677423 8.366855891879602e-10 2.5823469672999213 0.09325300170910389 0.18051848706021198 14080.676901522398 18.96270795257539 1086.2838107925272 1815.4290345148818 0.029999999983324383 1.5228787455217419 2.582346966463236 MPFLSISS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MPFLSIS(0.023)S(0.976)PK;MPFLSIS(0.023)S(0.976)PK 127.51 0.0032742 113874000.0 9271.7 7982.9 9508.900000000001 8764.8 6963.0 6513.299999999999 6018.8 7321.3 5121.6 6636.1 True False 9487.71257041233 7048.258356850477 8217.643608648896 7234.192215672848 6333.197879417494 6447.782115603226 5564.797070236317 7127.115341066007 8690.981133136092 7487.908076087888 1.2670711865054378 0.9412853743969692 1.0974551937798713 0.966116589862359 0.8457900143889479 0.8610925842150451 0.7431711251914415 0.9518166180252603 1.1606687802285038 1.0 12.870347008714525 -1.52287929022454 0.8734782170415916 0.9242144910082162 134.02697402124875 0.38102778342151133 0.1166545962897982 846.7451209836495 2.1092686741440714 0.041810497423739955 224312.47541702786 0.029999962356611704 1.52287929022454 133.10275953024052 MPFLSISS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MPFLSIS(0.004)S(0.996)PK 149.94 0.00072897 14888000.0 148990.0 132700.0 119630.0 135060.0 128790.0 110320.0 150600.0 121320.0 100860.0 120690.0 True False 140709.73225422588 142877.66330224805 111933.13604329566 116664.59500850474 112610.24880279151 125515.5786147491 157603.19840823853 121673.0211143929 121034.818263861 117205.36610972091 1.2005400172761846 1.2190368755684293 0.9550171614029199 0.9953861233562469 0.9607943095145685 1.0709030036837106 1.3446756205743984 1.0381181779722408 1.0326730104708275 1.0 16.83867909780328 -1.5228787452817119 0.009142092082900134 3.467901071921885e-09 2.295740958937372 0.05754865241783902 0.11943272016842822 71030.85953865724 50.38879256451806 5523.518257330102 7236.980620899947 0.029999999999905068 1.5228787452817119 2.295740955469471 MPFQTS(ph)PGGK ddPTM_A459_Selumetinib_30min_R2 1 MPFQTSPGGK 10 0 I6LM39;A0A087X1U4;P51608;P51608-2 I6LM39 MECP2 Methyl-CpG-binding protein 2 1 MPFQT(0.002)S(0.998)PGGK 107.03 0.011542 6304600.0 61835.0 51460.0 58723.0 58537.0 51030.0 50693.0 66787.0 66889.0 53723.0 55366.0 True False 58398.45824511746 55406.816530020355 54944.82611276811 50564.159618042606 44619.15518601178 57675.50060476328 69892.72783592978 67083.6359159299 64469.10114603799 53767.439721856135 1.086130538244298 1.0304901408109604 1.0218977581414086 0.94042342130508 0.8298545628512486 1.0726845262323053 1.2999080521127884 1.2476628283392266 1.1990360984183461 1.0 15.71444515507723 -7.006414314243747 24.537468316636495 1.2042911921802244 0.9810869742948345 0.4988964242312084 0.09615159906083974 179.6741841852556 687331.9338726953 0.03517410412956143 0.029940314648864746 9.853390297812562e-08 7.006414314243747 -0.2232042178853899 MPGVTPKQS(ph)DT(ph)Y(ph)FCMS(ph)MR ddPTM_A459_Selumetinib_30min_R2 1 MPGVTPKQSDTYFCMSMR 18 1 P19021-2;P19021-4;P19021-3;P19021-6;P19021;P19021-5 P19021-2 PAM Peptidyl-glycine alpha-amidating monooxygenase;Peptidylglycine alpha-hydroxylating monooxygenase;Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 4 MPGVT(0.487)PKQS(0.528)DT(0.993)Y(0.992)FCMS(1)MR 41.912 0.042621 11020000.0 94850.0 90346.0 85643.0 76622.0 61066.0 60678.0 88763.0 74041.0 39735.0 68657.0 True False 89578.616714634 97275.24769182327 80132.82262104818 66185.95141967763 53394.343143033424 69035.84371995779 92890.65538054772 74256.44705185252 47683.11028866259 66674.69401769085 1.343517477423534 1.4589530424543553 1.2018476245243281 0.9926697436679117 0.8008187203508764 1.0354129814475106 1.3931920760806336 1.1137126033476807 0.7151605416593406 1.0 16.024851678550654 -5.515963415997981 3.4012457391129467 1.021752504622815 1.3973075440024707 0.45426912453454626 0.172881126717763 0.23477447673576401 5.677397452544789 0.0515761000677165 0.1078130729285788 3.0481517483427843e-06 5.515963415997981 0.3755550393796556 MPIEDS(ph)SPEKGR ddPTM_A459_Selumetinib_30min_R1 2 MPIEDSSPEKGR 12 1 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 MPIEDS(0.5)S(0.5)PEKGR;MPIEDS(0.989)S(0.011)PEKGR 153.49 0.0022192 31650000.0 7037.299999999999 8332.7 7894.700000000001 7962.700000000001 7371.1 7364.1 7266.6 7172.7 4397.200000000001 7205.400000000001 True False 7201.25539779789 7357.103610232869 6822.643102482982 6572.163923391083 6704.385306473402 7290.023840067827 6718.474511626777 6982.456695786831 7461.727241218763 8130.283276539494 0.88573240966617 0.9049012635835593 0.8391642542357902 0.8083560805753872 0.8246189066768902 0.8966506568232013 0.8263518358595707 0.8588208378833739 0.9177696505053032 1.0 12.989089904433358 -8.553801875621105 2.288426821313815 0.9995817332657075 0.8541423393989248 0.6847820750015884 0.03065356348326517 0.19801007703572782 2.4355433955725374 0.031736989583576306 0.008699695537145228 2.7938180854586396e-09 8.553801875621105 -0.14543939386678273 MPIEDS(ph)SPEKGR ddPTM_A459_Selumetinib_30min_R2 1 MPIEDSSPEKGR 12 1 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 MPIEDS(0.5)S(0.5)PEKGR 98.654 0.0082965 34371000.0 133090.0 106730.0 106400.0 120500.0 120110.0 74772.0 106820.0 133260.0 91903.0 135610.0 True False 125693.39060148256 114915.84780895986 99554.33983956091 104087.69212590568 105020.70800297614 85071.16428736426 111787.34165981451 133647.76453761937 110286.1679843706 131694.58694290541 0.9544309566495349 0.8725935551077755 0.7559486092068574 0.7903718333619257 0.797456527567884 0.6459731281456984 0.8488377863873673 1.0148311152345293 0.8374388845016373 1.0 17.006836521996924 -7.5483529277664125 10.71440167903752 0.9422265065762423 0.7984073086453665 0.36830113152399235 0.08633744561862942 0.549704325580747 224.79768077614872 0.04164918192495728 0.024144995794917003 2.8290920104778375e-08 7.5483529277664125 -0.14381919793087583 MPIEDS(ph)SPEKGREEAASK ddPTM_A459_Selumetinib_30min_R2 1 MPIEDSSPEKGREEAASK 18 2 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 MPIEDS(0.5)S(0.5)PEKGREEAASK 68.944 0.030039 10323000.0 24011.0 27677.0 23392.0 23905.0 20897.0 12865.0 14231.0 12454.0 9495.2 23558.0 True False 22676.56474364865 29799.73690441844 21886.984187283888 20649.097761574885 18271.732038449692 14637.036973157621 14892.769698191538 12490.239078129312 11394.505318054842 22877.81932896519 0.9912030695573448 1.3025601992882923 0.9566901404616469 0.9025815557268362 0.7986658070734997 0.6397916148689021 0.6509698098426747 0.5459540919757002 0.49805906560458174 1.0 14.481661923220802 -6.045704612122113 1.121637553903783 0.6336909856409287 1.1477808165117558 0.5916249675340707 0.15116821449837972 0.31249371462505393 0.8033519555656843 0.057689242603448404 0.10971253038753634 9.001095880653645e-07 6.045704612122113 0.514089830870827 MPIVGLGT(ph)WK ddPTM_A459_Selumetinib_30min_R1 2 MPIVGLGTWK 10 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 MPIVGLGT(1)WK;MPIVGLGT(1)WK 130.44 0.0065 16257800.0 4419.5 7985.0 7308.0 8034.9 6443.2 5886.9 7351.5 7094.7 2829.9 5049.6 True False 4522.4657511499845 7050.112487874208 6315.613739970564 6631.75554875294 5860.413697639354 5827.683130877538 6796.970436273393 6906.525509166537 4802.133612281672 5697.765347269244 0.7937262199324262 1.2373469348387787 1.108436966958886 1.1639221948533434 1.0285459896041633 1.0228015328273496 1.1929186307279156 1.2121463570760445 0.8428099999911686 1.0 12.476180492616965 -8.267781267536202 24.99236553830439 0.9214049991368913 1.1011168914355671 0.2287046475858806 0.12710430366896383 767.6757715785615 3025241.3197058258 0.10758361848326246 0.030510512862539564 5.39782415538318e-09 8.267781267536202 0.1797118922986758 MPIVGLGT(ph)WK ddPTM_A459_Selumetinib_30min_R2 1 MPIVGLGTWK 10 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 MPIVGLGT(1)WK 111.5 0.02061 5036100.0 29559.0 24841.0 25484.0 26907.0 27336.0 15527.0 20273.0 18617.0 23776.0 22471.0 True False 27916.229114052352 26746.224823595734 23844.38718488127 23242.22018283604 23901.807293059326 17665.70330992758 21215.7346701874 18671.172387789728 28531.86435694578 21822.203843330382 1.279258012365443 1.2256426993174798 1.0926663207835874 1.0650720866554304 1.095297590686036 0.8095288375434558 0.9722086193724041 0.8556043432568466 1.3074694270929974 1.0 14.413509187594531 -5.338990098848307 1.0297341436799006 0.9888458297027969 1.3192006435455892 0.35772320511786715 0.12768950445782998 0.9452133630937257 1.445843121499349 0.04462535515803526 0.2818509559470592 4.581523316642497e-06 5.338990098848307 0.3303548138427923 MPIVGLGTWKS(ph)PLGK ddPTM_A459_Selumetinib_30min_R1 1 MPIVGLGTWKSPLGK 15 1 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 MPIVGLGT(0.013)WKS(0.987)PLGK 138.73 0.0018819000000000004 15716000.0 913.98 1002.3 1155.2 1635.0 1167.2 952.59 1067.3 1056.3 398.77 651.35 True False 935.2739557045056 884.9502500433715 998.3301850593864 1349.4779427511296 1061.6269660858977 943.0078094825175 986.7927017118401 1028.2834926540397 676.6835649915415 734.9571171862762 1.272555818338254 1.2040841966825655 1.3583516122429193 1.8361315390991746 1.4444747064294725 1.2830786823219653 1.3426534400941597 1.3991067895100326 0.9207116295195151 1.0 9.521516264720262 -8.258402521496215 24.247693699946996 0.9603557562090088 1.3963361673815453 0.5268358517239153 0.16380556046576344 139.00750953761093 1109937.2775824177 0.13414532752895145 0.04569112775175386 5.515659888816595e-09 8.258402521496215 0.4359804111725365 MPLDLS(ph)PLATPIIR ddPTM_A459_Selumetinib_30min_R1 2 MPLDLSPLATPIIR 14 0 B8ZZU6;E9PBF9;P15336-5;P15336;E9PEK8;H7C2N6;P15336-3;P15336-7;P15336-4;C9JCI8 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 MPLDLS(0.985)PLAT(0.015)PIIR;MPLDLS(1)PLATPIIR 177.88 7.089100000000001e-05 105008000.0 3163.8999999999996 3883.8 3247.8 3132.1 3819.6000000000004 2893.3 3196.8999999999996 3135.6000000000004 1705.72 3047.9 True False 3237.612714122285 3429.0828904703644 2806.7665988883964 2585.1375317986644 3474.11785440515 2864.1960289062126 2955.7552591610443 3052.433702135765 2894.482259140286 3439.1276540601093 0.941405216610694 0.997079269919543 0.816127483832951 0.7516840873140446 1.0101741499195973 0.8328263202224688 0.8594491267782941 0.8875604540390272 0.8416326901163919 1.0 11.747826951693257 -5.252327925798277 24.688640037084447 0.8692877522086123 0.9692422500460628 0.19508427285946273 0.07593815851445748 824.6430936435122 2234459.5266167857 0.01878698714672729 0.04817839753567252 5.593351009043398e-06 5.252327925798277 0.09995449783745047 MPLDLS(ph)PLATPIIR ddPTM_A459_Selumetinib_30min_R2 2 MPLDLSPLATPIIR 14 0 B8ZZU6;E9PBF9;P15336-5;P15336;E9PEK8;H7C2N6;P15336-3;P15336-7;P15336-4;C9JCI8 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 MPLDLS(1)PLATPIIR;MPLDLS(1)PLATPIIR 194.77 7.3018e-05 156535000.0 92396.0 69833.0 79979.0 92983.0 95681.0 56532.7 88794.0 89518.0 74830.0 89483.0 True False 87261.00021049369 75188.96655151388 74833.23821455093 80318.55499537835 83660.69738100709 64319.56627224467 92923.09694197301 89778.4825594974 89798.09092489281 86899.39328524441 1.004161213462818 0.865241559336422 0.8611479940822289 0.9242706071805971 0.9627305118965974 0.7401612812314788 1.069318132486334 1.0331312931587735 1.033356937604081 1.0 16.407058484006562 -7.306436085453619 24.998834750765827 1.0367125797184613 0.8948421305518953 0.5099710246884646 0.06767439815368817 365.7503869769396 203198.67417455037 0.02748148494991562 0.018528119028471825 4.938145869440483e-08 7.306436085453619 -0.141870449166566 MPLPS(ph)PTESR ddPTM_A459_Selumetinib_30min_R1 2 MPLPSPTESR 10 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 MPLPS(0.971)PT(0.028)ESR;MPLPS(0.869)PT(0.131)ESR 171.67 0.00016771 49346000.0 5438.299999999999 6957.9 5526.799999999999 5772.4 5869.6 4966.5 5873.5 5779.299999999999 3170.0 4647.4 True False 5565.001808910276 6143.265833360045 4776.290916539312 4764.358701367967 5338.695716362046 4916.541519221201 5430.457166218021 5626.014190187911 5379.258472360472 5243.939059509485 1.0612254920885413 1.1714983266671835 0.9108212094642617 0.9085457796707543 1.0180697479084406 0.9375664864574327 1.035568320796997 1.072860330057719 1.0258049171272492 1.0 12.35643520457448 -10.650346599811849 14.863889721027235 0.999999347386259 1.01414139939105 0.003393240129323405 0.07663277597503605 0.0 0.0 0.07942846222835263 0.019264231732228274 2.2369351827006555e-11 10.650346599811849 0.014142052004791017 MPLPS(ph)PTESR ddPTM_A459_Selumetinib_30min_R2 4 MPLPSPTESR 10 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 MPLPS(0.955)PT(0.043)ES(0.003)R;MPLPS(0.941)PT(0.057)ES(0.002)R;MPLPS(0.982)PT(0.017)ES(0.001)R;MPLPS(0.983)PT(0.017)ESR 156.01 0.00051582 85109200.0 137049.0 114730.0 147375.0 151044.0 154641.0 100882.0 118425.0 113663.0 134775.0 126721.0 True False 129432.36523061522 123529.42208490567 137893.0529497679 130471.54663456645 135213.6150719194 114777.5797843831 123931.99715468577 113993.7405120773 161733.765928136 123062.23546930145 1.0517634815995427 1.0037963442954094 1.1205147738776946 1.0602078382292452 1.0987417427960602 0.9326791387030751 1.0070676571254167 0.9263096845052329 1.314243685817664 1.0 16.909028579395233 -11.671947869262782 2.351133928170943 0.8882542987482157 1.0498614745801198 0.021793298073430334 0.10504277357490083 10831020.501128457 4742190.744406609 6393314.401491259 0.025325971603023925 2.128394513460917e-12 11.671947869262782 0.1616071758319041 MPNGLDGMSLS(ph)PPGAR ddPTM_A459_Selumetinib_30min_R2 1 MPNGLDGMSLSPPGAR 16 0 C9JLZ4;Q53TQ3 C9JLZ4 INO80D INO80 complex subunit D 1 MPNGLDGMS(0.089)LS(0.911)PPGAR 81.65100000000002 0.021257 3187100.0 7416.6 7148.7 10082.0 9869.3 10480.0 8239.2 8602.6 9797.6 8767.5 9051.4 True False 7004.415063002153 7696.982303306579 9433.33509645162 8525.084314507882 9163.408707611272 9374.075011989138 9002.637945728518 9826.109393920004 10521.244984418 8790.06256363849 0.7968561102143965 0.8756459066794798 1.0731817922973756 0.9698547937273241 1.042473661736742 1.066440078682319 1.0241836028527693 1.117865694672901 1.196947679068955 1.0 13.101657718509694 -3.729138221163057 0.542471195024522 1.0882665141920411 5.591080536952383e-10 0.6930178953009151 0.06064561304428128 6.572109833148347 0.6179108804275721 0.03215875750853772 5.813613672262355 0.0001865785780171209 3.729138221163057 -1.088266513632933 MPPRCSSPT(ph)VGPPPLPQKSLET(ph)RAQK ddPTM_A459_Selumetinib_30min_R2 1 MPPRCSSPTVGPPPLPQKSLETRAQK 26 3 E9PI79 E9PI79 PPFIBP2 2 MPPRCS(0.303)S(0.324)PT(0.373)VGPPPLPQKS(0.494)LET(0.506)RAQK 56.383 0.024211 0.0 9092.9 7669.2 9692.1 8949.9 7591.8 9087.2 9521.0 9557.8 6145.5 8656.2 True False 8587.553019762727 8257.402979635293 9068.520837960592 7730.908180561348 6638.050212446881 10338.879314611573 9963.745365503588 9585.611615621028 7374.771719616861 8406.273014491404 1.021564848650385 0.9822906019588614 1.0787801945437119 0.9196594218667644 0.789654368946105 1.2299004917861445 1.1852750140671482 1.140292683701396 0.8772938622031002 1.0 13.037250596999787 -6.773606931109348 24.999995758002967 1.101490821545763 0.9642543333087283 0.22787190863588114 0.11609436419628612 344.09815654175264 706994.8670216405 0.042394518717248815 0.03766276689891739 1.6841976959671928e-07 6.773606931109348 -0.13723648823703471 MPQDGS(ph)DDEDEEWPTLEK ddPTM_A459_Selumetinib_30min_R1 2 MPQDGSDDEDEEWPTLEK 18 0 F8WBL2;Q13895 F8WBL2 BYSL Bystin 1 MPQDGS(1)DDEDEEWPTLEK;MPQDGS(1)DDEDEEWPTLEK 142.22 0.00020062 18083500.0 12895.0 15262.2 15770.7 16357.5 15168.8 13857.4 14057.6 13778.4 7837.8 11706.6 True False 13195.428410697818 13475.294528795715 13629.125562254214 13500.969693303743 13796.784718269157 13718.007137512504 12997.223914161317 13412.952073449238 13300.1741497372 13209.256141940366 0.9989531786579076 1.020140300407277 1.0317860003471908 1.0220840256429857 1.0444785512534156 1.0385147346758472 0.983948208324477 1.0154206966175878 1.0068829014154825 1.0 13.689261605365845 -7.250848646026112 24.992916452008835 1.002848008993287 1.0266526929890565 0.4341263409729007 0.01361996355020871 761.8279969447855 1797836.7082068296 0.005489258093031662 0.004203253502366558 5.612435383593278e-08 7.250848646026112 0.023804683995769516 MPQDGS(ph)DDEDEEWPTLEK ddPTM_A459_Selumetinib_30min_R2 2 MPQDGSDDEDEEWPTLEK 18 0 F8WBL2;Q13895 F8WBL2 BYSL Bystin 1 MPQDGS(1)DDEDEEWPTLEK;MPQDGS(1)DDEDEEWPTLEK 126.86 0.00056146 0.0 39341.0 41382.0 43802.0 52841.0 45306.0 38578.0 40920.0 39666.0 35061.0 40966.0 True False 37154.58471450092 44555.86633589782 40983.827008011685 45643.964644190666 39614.25523922105 43891.769323783505 42822.86108144174 39781.42149294019 42074.179686191 39783.20513754937 0.933926378883751 1.1199667342499706 1.0301791136815448 1.1473174292110924 0.9957532356243249 1.1032738355803382 1.0764055066298164 0.9999551658896509 1.0575864750142843 1.0 15.279871891260948 -8.34633053634233 1.043726736223267 1.005666203992087 1.0604431585250444 0.05303948422827809 0.061271799668900236 1.3742035319392492 3.1833690323321013 0.05425728135101514 0.01820650053017054 4.504737238686477e-09 8.34633053634233 0.0547769545329575 MPQPSS(ph)GRESPRH ddPTM_A459_Selumetinib_30min_R2 1 MPQPSSGRESPRH 13 2 P56181-2;P56181 P56181-2 NDUFV3 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 1 MPQPS(0.004)S(0.498)GRES(0.498)PRH 83.226 0.035557 3485500.0 20713.0 17317.0 20314.0 18756.0 20026.0 16314.0 15845.0 15663.0 15662.0 19583.0 True False 19561.854380708613 18645.15821706884 19007.01935621088 16201.400444095305 17510.154845288507 18561.105416252893 16581.823896271864 15708.576736850764 18794.837632843406 19017.58790725551 1.0286191117457886 0.9804165653392573 0.999444274894578 0.851916684865919 0.9207347919558245 0.9759968249796567 0.8719204547462949 0.8260025831592288 0.9882871436956986 1.0 14.215046653354735 -5.729315302566464 23.457079455700264 0.9124679436670358 1.000585903714597 0.31262832758982406 0.05612080901913186 114.24883843472728 83422.94676530911 0.01499876295768036 0.025974462607654146 1.865025170426722e-06 5.729315302566464 0.08811796004756123 MPQPSSGRES(ph)PRH ddPTM_A459_Selumetinib_30min_R1 1 MPQPSSGRESPRH 13 2 P56181-2;P56181 P56181-2 NDUFV3 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 1 MPQPSS(0.004)GRES(0.996)PRH 127.07 0.029692000000000007 0.0 900.32 784.64 975.2 940.4 921.33 865.82 1002.9 866.88 546.83 608.46 True False 921.295704282239 692.7739840307601 842.7731963901604 776.1767934942889 837.9958641740232 857.1106369016608 927.2504455605778 843.8875263769143 927.9305711169964 686.5617679022979 1.3418977684952378 1.009048298957052 1.2275271298096697 1.1305272588448936 1.2205687868906725 1.2484100877339168 1.3505710467882206 1.2291501884168488 1.3515616722325947 1.0 9.423245710930248 -6.520864845974522 3.6795111206118563 1.2566908619859736 1.1687841905640681 0.03461909296815335 0.12043480656756335 0.533999189115762 15.779436705595558 0.03764041476862874 0.03999299393325312 3.013943828557718e-07 6.520864845974522 -0.08790667142190545 MPQSMPEY(ph)ALT(ph)RNY(ph)LELMVELPWNK ddPTM_A459_Selumetinib_30min_R1 1 MPQSMPEYALTRNYLELMVELPWNK 25 1 H3BQ67;E7EN44;Q86WA8-2;Q86WA8 H3BQ67 LONP2 Lon protease homolog 2, peroxisomal 3 MPQS(0.085)MPEY(0.918)ALT(0.997)RNY(1)LELMVELPWNK 48.597 0.026063 96181000.0 525.27 629.39 669.06 664.66 586.7 626.72 632.33 577.21 305.88 449.22 True False 537.5077690025009 555.7007262045271 578.2053268835119 548.5896082134349 533.6330885902981 620.4157658162309 584.6328390081962 561.9005157576806 519.0560194087136 506.8817627733462 1.0604204145392566 1.096312329652725 1.1407104562608978 1.0822831841727525 1.0527762641736902 1.2239851803341595 1.153390952180729 1.1085435638546266 1.0240179417163429 1.0 8.985505447547512 -8.302874026798715 3.540953921151043 1.0029136093859152 1.1174190950668739 0.4345422003673586 0.04727209462636818 0.23211337748570762 5.699502529946005 0.04635524152337208 0.012877856537054621 4.978814815375263e-09 8.302874026798715 0.11450548568095864 MPS(ph)FGVSAPGK ddPTM_A459_Selumetinib_30min_R1 2 MPSFGVSAPGK 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 MPS(0.997)FGVS(0.003)APGK;MPS(0.943)FGVS(0.057)APGK 111.94 0.007960600000000002 39889000.0 4981.0 3384.9 3569.2000000000003 3904.9 3203.1000000000004 3702.2 3342.8999999999996 3245.5 1776.32 2724.3 True False 5097.047608661177 2988.5943344026814 3084.522244212226 3222.9825190513056 2913.3801705532364 3664.9592293286455 3090.7423616157707 3159.418797130253 3014.2853027203014 3073.990441929184 1.6581208383531463 0.972219787556363 1.0034261011808587 1.0484686208160807 0.9477518637711992 1.1922480887834446 1.0054495679160518 1.0277907029364268 0.9805773178749988 1.0 11.585896963873333 -4.75861283271131 24.999979499871355 1.0237165696840114 1.658121689839603 0.9002430235769555 0.06373665205891026 21.871972385129723 193415.23934569673 0.015551988271857175 0.10507811892308194 1.743360361538298e-05 4.75861283271131 0.6344051201555916 MPS(ph)FGVSAPGK ddPTM_A459_Selumetinib_30min_R2 1 MPSFGVSAPGK 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 MPS(0.944)FGVS(0.056)APGK 122.34 0.0041787 14644000.0 61733.0 40317.0 61287.0 59086.0 50710.0 29899.0 41334.0 38413.0 34504.0 38738.0 True False 58302.12699677909 43409.184260412585 57343.86114424022 51038.38487096482 44339.356446848054 34017.31585390126 43256.11290176716 38524.7754703855 41405.76412231066 37619.53328658859 1.5497833679282744 1.1539001276203502 1.5243108070318188 1.3566990446731586 1.1786259045019862 0.9042460892524808 1.1498311946679047 1.0240630891643634 1.1006453431221028 1.0 15.199194330236692 -6.389140464763841 3.180856337204037 1.044004098698919 1.389908759170962 0.6738433668140977 0.1177548991126167 0.1536130931584203 2.9336812973139224 0.03661994955528104 0.04203450979879595 4.081873441023111e-07 6.389140464763841 0.34590466047204305 MPS(ph)LEISAPK ddPTM_A459_Selumetinib_30min_R1 2 MPSLEISAPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MPS(0.992)LEIS(0.008)APK;MPS(0.995)LEIS(0.005)APK 153.54 0.00059179 44189000.0 3461.3999999999996 3899.4 4922.7 4125.1 3881.3 3659.5 3564.5 3562.2 2355.7 2847.5 True False 3542.043885288051 3442.8564352181197 4254.224378455541 3404.7287227172396 3530.237100299172 3622.688752560151 3295.626895204585 3467.7188843436716 3997.4508464793566 3213.0043619988064 1.1024086761850984 1.0715380520293856 1.3240643021751122 1.0596713664587625 1.0987339893005983 1.1275081961938205 1.0257150392271421 1.0792761209282664 1.244147345007819 1.0 11.649707224086344 MPS(ph)LEISAPK ddPTM_A459_Selumetinib_30min_R2 1 MPSLEISAPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MPS(0.973)LEIS(0.027)APK 92.792 0.026128 10055000.0 71511.0 72752.0 70912.0 80920.0 73418.0 49125.0 73538.0 60935.0 53234.0 67308.0 True False 67536.70490121446 78331.84446544985 66349.59912314784 69898.55640521387 64194.57447475238 55891.52283765007 76957.66271278249 61112.310761667715 63882.28748223644 65364.64315281382 1.0332299182498808 1.1983824998833152 1.015068635317588 1.0693633902628423 0.982099364096183 0.8550727142651592 1.1773591807556532 0.9349444564211157 0.9773217507343867 1.0 15.996222847972073 -5.7521343713637645 1.6910812732403697 0.9903987378455442 1.1098764317461784 0.20308600928151122 0.08797883920242855 0.565361469759431 3.2832253587072087 0.02734803184866411 0.05907243288410947 1.7695613686689928e-06 5.7521343713637645 0.11947769390063423 MPSFGMLS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 MPSFGMLSPGK 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 MPSFGMLS(1)PGK 107.39 0.010575 48159000.0 2383.6 3042.8 2791.7 3163.2 2737.1 2305.5 2255.6 2556.4 1661.8 2257.6 True False 2439.13324232178 2686.5475614406573 2412.6024737104303 2610.806500617966 2489.5297882742548 2282.3087632265133 2085.458276006023 2488.595967642514 2819.9532269301676 2547.384950886216 0.9575047703226888 1.0546295959336762 0.9470898667557506 1.0248967278030303 0.9772884099861571 0.8959418412331106 0.8186663249621962 0.9769218298854873 1.1069992487586642 1.0 11.31480127520077 -3.9136619025757367 14.982961536656223 0.9715361322607484 0.9766281290406058 0.0 0.07671544357708157 0.0 0.0 0.018543532849845647 0.0 0.00012199389494840994 3.9136619025757367 0.005091996779857388 MPSFGMLS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 MPSFGMLSPGK 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 MPSFGMLS(1)PGK;MPSFGMLS(1)PGK 104.59 0.012181 45076000.0 185817.0 174353.0 151522.0 180331.0 149397.0 108681.0 169124.0 154003.0 125403.0 149984.0 True False 175490.03502438747 187725.31446674356 141773.23948467977 155769.6067116739 130628.41323387416 123650.82124210984 176988.6011128483 154451.12323343082 150487.1040525768 145653.57221476873 1.2048453900301488 1.2888479946783544 0.9733591653737997 1.0694527044073379 0.8968431824058547 0.848937786845245 1.2151339539539443 1.0604005166841355 1.033185123882035 1.0 17.15218155904816 -5.261691548266633 24.999633045374672 1.0136680484381537 1.2468467063438582 0.4881273800915793 0.09611932101648638 18.662278290085652 1850375.2486776162 0.026342153236517087 0.06099047396679467 5.474046115219042e-06 5.261691548266633 0.23317865790570447 MPTQSEEEKLSPS(ph)PTTEDPR ddPTM_A459_Selumetinib_30min_R1 3 MPTQSEEEKLSPSPTTEDPR 20 1 F6RRE2;E7EV10;Q9BTC8;E7EQY4;Q9BTC8-2 F6RRE2 MTA3 Metastasis-associated protein MTA3 1 MPTQSEEEKLS(0.028)PS(0.523)PT(0.225)T(0.225)EDPR;MPTQSEEEKLS(0.076)PS(0.375)PT(0.275)T(0.275)EDPR;MPTQSEEEKLS(0.001)PS(0.622)PT(0.149)T(0.228)EDPR 86.8 0.00122 29667300.0 2891.55 3378.26 5378.9 5306.400000000001 3392.79 4018.7000000000003 3584.77 3562.2 2039.0500000000002 3225.13 True False 2958.917489023131 2982.731748689536 4648.474924182769 4379.7368534645875 3085.9127435457253 3978.275526687656 3314.367912785114 3467.7188843436716 3460.118923680324 3639.1068509264987 0.8130889281994579 0.8196329129303106 1.2773669789331112 1.2035197186775453 0.8479862971762061 1.0932010764330282 0.9107641101390833 0.9529038377811873 0.9508154240646698 1.0 11.829368696665695 -7.2870326864983275 24.637763723259145 0.9496961709698067 1.0142224606499304 0.031415647429963056 0.14877099657413304 2826.3049812652157 2720766.7841042625 0.06708379016674991 0.045247618643104365 5.163775034602953e-08 7.2870326864983275 0.06452628968012364 MPTQSEEEKLSPSPT(ph)TEDPR ddPTM_A459_Selumetinib_30min_R2 2 MPTQSEEEKLSPSPTTEDPR 20 1 F6RRE2;E7EV10;Q9BTC8;E7EQY4;Q9BTC8-2 F6RRE2 MTA3 Metastasis-associated protein MTA3 1 MPTQSEEEKLS(0.001)PS(0.227)PT(0.386)T(0.386)EDPR;MPTQSEEEKLSPS(0.049)PT(0.475)T(0.475)EDPR 88.319 0.0027654 44415000.0 142194.0 120594.0 116200.0 129732.0 114665.0 72063.0 100476.0 101746.0 81094.0 109305.0 True False 134291.4267276822 129843.17202917379 108723.81850899383 112062.27779981725 100259.75758189392 81989.02412721778 105148.33308941702 102042.06401504284 97315.06595567655 106149.08064150333 1.2651209592782424 1.2232152294158098 1.0242558659192362 1.0557065320074182 0.9445183790192269 0.7723950469634197 0.9905722447520189 0.9613089760020523 0.916777284999181 1.0 16.69573235053467 -5.326776117156128 1.101285789308877 0.9279586598643443 1.3163288302424452 0.7622548650543055 0.06628948995931068 0.3915885327445843 0.6991934219252754 0.023312442996703066 0.14310566774579797 4.712201821800996e-06 5.326776117156128 0.38837017037810084 MQAGQISVQSSEPSS(ph)PEPGK ddPTM_A459_Selumetinib_30min_R2 2 MQAGQISVQSSEPSSPEPGK 20 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 MQAGQISVQSSEPS(0.24)S(0.76)PEPGK;MQAGQISVQSSEPS(0.008)S(0.992)PEPGK 290.18 2.286999999999999e-153 3367000.0 28652.0 19960.8 24504.0 28330.0 25129.0 27657.0 36841.0 37972.0 30427.0 22360.1 True False 27059.636543043674 21491.729175911973 22927.43931793795 24471.405128024122 21972.070363889674 31466.50070475089 38554.179499056576 38082.49223339699 36513.25020141276 21714.505814483167 1.2461548411106553 0.9897406535302035 1.0558582135747145 1.1269611814836769 1.0118614050721209 1.4491004756720425 1.775503427452706 1.7537812077674215 1.6815142151224602 1.0 14.406371499409769 -6.8972793978748586 4.179453871542763 1.6158073079353708 1.0823319102461053 0.5063750669168653 0.21776922793825565 0.1542365143204845 4.900652860638107 0.07518833276334326 0.06581652395469867 1.2668366002991274e-07 6.8972793978748586 -0.5334753976892654 MQAHIQDLEEQLDEEEGAR ddPTM_A459_Selumetinib_30min_R1 2 MQAHIQDLEEQLDEEEGAR 19 0 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 0 ; 148.36 0.00073463 7665500.0 1674.45 1965.72 2424.15 2632.3 2411.7 1771.0099999999998 2060.27 1926.94 988.22 1432.48 False True 1713.4614270874729 1735.572588561564 2094.963744902798 2172.618219390704 2193.562160820218 1753.195247348422 1904.8621751671058 1875.8312916167515 1676.9371632668974 1616.352761536803 1.060078881208048 1.0737585444599413 1.2961055252016518 1.3441485491849021 1.3571060804416317 1.0846612751052631 1.178494088973494 1.160533354014405 1.0374821655097688 1.0 10.658526378655385 -8.182937095453122 1.1206096770575045 0.9953432118807523 1.2133352239655024 0.32874855008943626 0.10211082266057359 0.6171564564740379 1.5072797408819334 0.10648742094322847 0.035890955032935094 6.562403112820419e-09 8.182937095453122 0.21799201208475016 MQAS(ph)IEK ddPTM_A459_Selumetinib_30min_R1 6 MQASIEK 7 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK 112.71 0.014447 1052448000.0 25024.800000000003 34979.799999999996 32742.300000000003 38323.700000000004 31040.199999999997 28575.4 35884.1 31491.999999999996 20581.699999999997 28632.8 True False 25607.829150215657 30884.34875433217 28296.075500579947 31631.185219945877 28232.619390592394 28287.957420387287 33177.33344654534 30656.729859567386 34925.64167210773 32308.098787090235 0.7926133109524881 0.9559321010456062 0.8758198892188165 0.9790481770033822 0.8738557962399714 0.8755686184694554 1.0269045438168103 0.948886842942838 1.081018165205791 1.0 14.979608235348055 -7.262958762519036 24.83973384965522 1.0099429626245835 0.8974168003121631 0.5281183398085346 0.056335138846481905 107.09767928852767 1750869.8574969543 0.02164241266266469 0.01548800422995686 5.4580968479354726e-08 7.262958762519036 -0.11252616231242041 MQAS(ph)IEK ddPTM_A459_Selumetinib_30min_R2 6 MQASIEK 7 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK;MQAS(1)IEK 103.26 0.018752 1275829300.0 2258677.0 2266478.0 2444713.0 2313292.0 2097725.0 1782981.0 2001915.0 1997179.0 1667509.0 2000275.0 True False 2133148.774540426 2440309.5747245927 2287422.827182261 1998217.6389487162 1834190.0316005608 2028570.4484599715 2095008.0142193185 2002990.4602392172 2001057.3940943063 1942521.8634114019 1.098133727459958 1.2562584857804329 1.1775531952907616 1.028671891208217 0.9442313449071859 1.0442973573010157 1.0784990654056912 1.0311289144110956 1.0301337821650594 1.0 20.8894994058247 -5.757785592241492 6.201523779125629 1.0232962371017165 1.1863906000382356 0.6852103868606323 0.0480348366027365 0.0816521979457954 12.433689107868108 0.013483815440757243 0.021988263999608425 1.7466842643316465e-06 5.757785592241492 0.16309436293651913 MQDY(ph)NKDDMSYRR ddPTM_A459_Selumetinib_30min_R2 1 MQDYNKDDMSYRR 13 2 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;E9PRE3;E9PRJ0;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 MQDY(0.999)NKDDMS(0.001)YRR 72.325 0.036874 851810000.0 29071.0 33994.0 118960.0 170010.0 209310.0 124360.0 63740.0 99797.0 155550.0 123750.0 True False 27455.350200433542 36601.230492062015 111306.24311385509 146854.34471639147 183014.6065448585 141489.46117231873 66704.03629841394 100087.39274771734 186664.34643013583 120177.01595888616 0.22845757969083133 0.30456098614217286 0.9261857787510229 1.2219836176214587 1.5228752776443524 1.177342106919378 0.5550481992433071 0.8328330666985301 1.553244977342387 1.0 16.87480147919819 -5.309009242908691 3.125172973811694 1.110292920818953 0.23383159228339473 0.5929051613842795 0.27990959235278656 0.18630020890918325 3.6118247597249864 0.08230581575617298 0.21992783515687056 4.908974284757837e-06 5.309009242908691 -0.8764613285355582 MQEAMTQEVSDVFSDTT(ph)TPIK ddPTM_A459_Selumetinib_30min_R2 1 MQEAMTQEVSDVFSDTTTPIK 21 0 P18206;P18206-2 P18206 VCL Vinculin 1 MQEAMTQEVS(0.001)DVFS(0.111)DT(0.083)T(0.403)T(0.403)PIK 79.635 0.0029153 958210.0 4904.3 4499.5 5676.3 7787.3 7233.1 5293.9 4442.4 5894.6 4521.6 5089.9 True False 4631.738639468418 4844.59718182718 5311.093037888146 6726.656306158216 6324.413313265565 6023.086671760527 4648.980402448603 5911.752310096437 5426.046344059811 4942.9413618515955 0.9370409843853371 0.9801041176042646 1.0744802839212 1.3608610367245892 1.2794837830923567 1.2185227844791418 0.9405291428962296 1.195998875431112 1.0977363368978441 1.0 12.271154076539794 -5.395693834084006 3.751576504918571 1.165850895838228 0.9586713466341201 0.2981944040114265 0.11842253889390231 0.2860376019587293 7.044852202581441 0.03350447908534416 0.07600106515078792 4.020741624179078e-06 5.395693834084006 -0.20717954920410797 MQEAMTQEVSDVFSDTTT(ph)PIK ddPTM_A459_Selumetinib_30min_R1 3 MQEAMTQEVSDVFSDTTTPIK 21 0 P18206;P18206-2 P18206 VCL Vinculin 1 MQEAMTQEVSDVFSDT(0.001)T(0.231)T(0.768)PIK;MQEAMTQEVSDVFS(0.007)DT(0.007)T(0.144)T(0.841)PIK;MQEAMTQEVSDVFS(0.001)DT(0.002)T(0.201)T(0.795)PIK 167.95 4.2014e-10 8105400.0 5514.4 5415.7 4527.18 5250.65 5535.4 4722.1 5212.9 4999.0 3082.4300000000003 4933.76 True False 5642.874790845448 4781.627326309378 3912.413822019694 4333.722544407476 5034.724047354245 4674.599961323756 4819.686756070129 4866.410280959523 5230.658578220219 5567.05615489209 1.0136191613383911 0.8589148722898169 0.7027796582546834 0.7784585647836849 0.904378168150854 0.8396897446805739 0.865751417261131 0.8741442776148631 0.9395735255200797 1.0 12.44269892040324 -8.395934297332381 1.057020131708816 1.0010288354350303 0.8416617686242076 0.2877513389123343 0.07565958112504963 0.6740079268485161 1.6277662964316502 0.07611036560982645 0.02523024916464295 4.018516007649462e-09 8.395934297332381 -0.1593670668108227 MQEAMTQEVSDVFSDTTT(ph)PIK ddPTM_A459_Selumetinib_30min_R2 2 MQEAMTQEVSDVFSDTTTPIK 21 0 P18206;P18206-2 P18206 VCL Vinculin 1 MQEAMTQEVSDVFS(0.001)DT(0.027)T(0.245)T(0.727)PIK;MQEAMTQEVSDVFSDT(0.006)T(0.242)T(0.751)PIK 112.06 0.00054174 0.0 7021.700000000001 7587.5 10101.400000000001 12871.2 11362.4 7081.0 9050.3 9282.3 9390.2 10302.7 True False 6631.462024092201 8169.436852342198 9451.486921572745 11118.120355941539 9934.953730855192 8056.343475081936 9471.156882829237 9309.309956232508 11268.502384109712 10005.234281370647 0.6627992746196582 0.8165162976296685 0.9446542335516362 1.1112303863431805 0.9929756217056991 0.8052128764323421 0.9466202006347976 0.9304439750667385 1.1262607218594791 1.0 13.288467329163351 -5.002047443614369 2.2020864144109478 0.9780733253322152 0.6476805922931103 0.5877849207985804 0.08624189474790694 0.3133797628824106 2.447207475206244 0.024737719119710958 0.1706890455934401 9.95296682257507e-06 5.002047443614369 -0.330392733039105 MQEEVVRR ddPTM_A459_Selumetinib_30min_R1 2 MQEEVVRR 8 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 127.46 0.022743 10931000.0 3910.2 3691.4 9948.9 9709.8 7685.9 5073.0 4905.2 4974.2 3430.0 3129.1 False True 4001.30005207527 3259.209171914697 8597.894025395886 8014.165705519826 6990.711702055859 5021.970225915465 4535.196814800821 4842.26805752128 5820.459482711805 3530.750465015089 1.133271833204494 0.9230924711924575 2.4351463267056856 2.2698193443374866 1.9799506567581755 1.4223520681159219 1.284485227641665 1.3714557586273903 1.6485049114585137 1.0 11.785759147219096 -6.884437611230142 6.7694284637024795 1.357084524470089 1.7683349917547138 0.1637315792671049 0.45576647905699563 0.4758005794401616 26.377759788015123 0.17967893273273203 0.1585099536199763 1.3048554047687044e-07 6.884437611230142 0.41125046728462467 MQHLIAR ddPTM_A459_Selumetinib_30min_R1 2 MQHLIAR 7 0 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 124.37 0.0092305 51815000.0 13572.9 15617.4 14530.2 15808.900000000001 13464.7 12324.4 12597.400000000001 12600.7 8267.1 10414.4 False True 13889.122161734045 13788.907547667723 12557.078648675466 13048.172384806323 12246.820262385869 12200.42772565988 11647.167975775075 12266.48850315797 14028.664894905756 11751.189684846482 1.1819332794571848 1.1734052395945016 1.0685793511501396 1.110370331408431 1.0421770553307055 1.0382291540568616 0.991147984854202 1.043850778698261 1.19380805443011 1.0 13.520519201492402 -5.226964549169881 1.1780816722011553 1.0527609235444175 1.2096313605746933 0.41630140481351174 0.054937822896711175 0.8164961908851196 1.5780917156002752 0.018074419829366816 0.13028376512315112 5.929737261917125e-06 5.226964549169881 0.1568704370302758 MQHLIAR ddPTM_A459_Selumetinib_30min_R2 2 MQHLIAR 7 0 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 114.19 0.019415 37966000.0 158611.0 149148.0 139311.0 166914.0 170435.0 143969.0 141942.0 146885.0 128063.0 153719.0 False True 149796.03559014032 160587.1720135927 130347.88193034846 144180.02525728944 149023.43159176776 163799.42292953967 148542.5842527373 147312.41103187914 153679.17837918721 149280.7330600734 1.0034519024625874 1.0757394388528985 0.8731728419225675 0.9658314392070185 0.9982763919828683 1.0972576271019763 0.9950552975443987 0.9868146277965947 1.0294642532157434 1.0 17.187668450275133 -6.526985504997865 24.956929563172896 1.0223988477544796 0.979225428382377 0.1185910053962026 0.05431187525115612 271.66634774013 1650904.3820958773 0.018660477427896865 0.018737618643955487 2.971765215646876e-07 6.526985504997865 -0.04317341937210262 MQNGFGSPEPSLPGT(ph)PHSPAPPSGGTWK ddPTM_A459_Selumetinib_30min_R2 1 MQNGFGSPEPSLPGTPHSPAPPSGGTWK 28 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 MQNGFGS(0.001)PEPS(0.005)LPGT(0.541)PHS(0.408)PAPPS(0.026)GGT(0.019)WK 66.972 0.0010979000000000002 7166400.0 22107.0 26069.0 31902.0 30457.0 38441.0 23775.0 27904.0 23815.0 25451.0 27642.0 True False 20878.38144133275 28068.40847495339 29849.460052271337 26308.704058744468 33611.697913099706 27049.7904420383 29201.59129072705 23884.29770721451 30541.91116035614 26843.90363745888 0.7777699444650948 1.0456157514954643 1.1119642081645087 0.9800625279414438 1.2521166208552776 1.0076697788578006 1.0878295379505898 0.8897475579477779 1.1377596780572903 1.0 14.7123068628945 -4.762609043763472 5.7811555150152225 1.0591415812456006 0.7662373499085697 0.4437099163546072 0.0938787122209511 0.12599621370219227 14.915173796983861 0.022369239636437804 0.14697345614751156 1.7273922080232757e-05 4.762609043763472 -0.2929042313370309 MQNGFGSPEPSLPGTPHS(ph)PAPPSGGTWK ddPTM_A459_Selumetinib_30min_R2 1 MQNGFGSPEPSLPGTPHSPAPPSGGTWK 28 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 MQNGFGSPEPS(0.002)LPGT(0.163)PHS(0.804)PAPPS(0.01)GGT(0.021)WK 83.236 2.9216e-05 6193900.0 40479.0 31768.0 46182.0 50162.0 52635.0 38097.0 36673.0 39246.0 35066.0 46072.0 True False 38229.33923027587 34204.50344978017 43210.70039915974 43329.849065723436 46022.52073712973 43344.515939866775 38378.3671661709 39360.199362474945 42080.17982590265 44741.78165056816 0.8544438290107835 0.7644868440178849 0.965779609239388 0.9684426383403354 1.0286251248679388 0.9687704499205243 0.8577746739256984 0.8797190882981997 0.9405119392550673 1.0 15.449335086265243 -5.268267245374706 24.98024071342153 0.9475786655963041 0.8094653338787555 0.5399439661387357 0.05224743850496966 397.2551471616668 1453390.8129052103 0.015065990725327626 0.03247475304668675 5.3917873396463985e-06 5.268267245374706 -0.13811333171754858 MQNNSSPS(ph)ISPNTSFTSDGSPSPLGGIK ddPTM_A459_Selumetinib_30min_R2 1 MQNNSSPSISPNTSFTSDGSPSPLGGIK 28 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 MQNNS(0.003)S(0.038)PS(0.899)IS(0.06)PNT(0.001)SFTSDGSPSPLGGIK 138.25 1.0999e-12 6619500.0 34605.0 28891.0 43762.0 38433.0 41828.0 27163.0 33281.0 30161.0 27425.0 36735.0 True False 32681.79263479078 31106.846800793217 40946.40056446299 33198.35909937703 36573.192692935554 30904.4566888364 34828.632445050396 30248.763516577674 32910.76631852448 35674.365101007585 0.9161142053195985 0.8719663745302264 1.1477821805245385 0.9305942517934082 1.025195335344667 0.8662931099497979 0.9762929864746689 0.8479131564340953 0.9225326428470889 1.0 15.12260013374163 -6.75913671555031 24.999782157376846 0.9164563675380034 0.9791833198987371 0.10263477781294095 0.08135612051910503 136.6824165164984 1483950.4439725163 0.02724501731099429 0.026012010571895214 1.7412586402981933e-07 6.75913671555031 0.06272695236073367 MQNNSSPSIS(ph)PNTSFTSDGSPSPLGGIK ddPTM_A459_Selumetinib_30min_R2 1 MQNNSSPSISPNTSFTSDGSPSPLGGIK 28 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 MQNNSSPS(0.003)IS(0.881)PNT(0.107)S(0.008)FTSDGSPSPLGGIK 131.75 1.8966e-12 7837400.0 129560.0 111120.0 132220.0 137500.0 147290.0 98042.0 110640.0 119780.0 102840.0 114820.0 True False 122359.57386977292 119642.5466928852 123713.10915025146 118772.26279926999 128786.11341069316 111546.39556333619 115784.97922900083 120128.5399693536 123410.87358968324 111504.84826181296 1.0973475662912262 1.0729806690733747 1.1094863683395502 1.0651757717332 1.1549821861404972 1.0003726053366369 1.0383851557480097 1.0773391636504652 1.1067758533684111 1.0 16.76674691472777 -6.768207395712839 24.999847418412497 1.0490214289211945 1.0970866942742188 0.34793594470016287 0.03758395063765854 219.22073313843742 809758.7985060228 0.013171559680993518 0.011868227749230876 1.7052678502159168e-07 6.768207395712839 0.048065265353024245 MQNTDDEERPQLS(ph)DDER ddPTM_A459_Selumetinib_30min_R2 2 MQNTDDEERPQLSDDER 17 1 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 MQNTDDEERPQLS(1)DDER;MQNTDDEERPQLS(1)DDER 63.54600000000001 0.026624 31060000.0 46738.0 29173.0 47726.0 59994.0 64031.0 50457.0 57331.0 59117.0 60335.0 36948.0 True False 44140.48906703806 31410.475294020285 44655.36112013985 51822.713704577414 55986.85333559714 57406.99374695794 59997.00509922133 59289.02068265383 72403.68590075403 35881.21523756712 1.230183782092854 0.8754016575540609 1.2445331303435432 1.4442853554837176 1.560338828128087 1.5999177666327653 1.6721006995439027 1.6523693606837224 2.0178716194915385 1.0 15.130941132335106 -5.802581631614918 1.6930075329460164 1.6257276391763347 1.0448494397994301 0.4157998299409572 0.24961206699159919 0.3130728204439926 1.8287615062210236 0.07580802093906892 0.15452022561816908 1.575499858065583e-06 5.802581631614918 -0.5808781993769045 MQPQASAIPS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 MQPQASAIPSPGK 13 0 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 MQPQASAIPS(1)PGK;MQPQASAIPS(1)PGK 163.62 0.00036297 15490700.0 84983.0 67730.0 72234.0 80520.0 85201.0 81395.0 90140.0 83309.0 70153.0 77037.0 True False 80259.98507390343 72924.67321372496 67586.54308243262 69553.0370952523 74497.28867339589 92606.42241975629 94331.68860902138 83551.41539745258 84185.5602385943 74812.74164383608 1.07281170707525 0.9747627424336389 0.903409520856681 0.9296950702111163 0.9957834325609669 1.2378429179969273 1.2609040457053413 1.1168072919345617 1.125283720243535 1.0 16.190996381492653 -6.6601974023495485 6.241959761624117 1.1619080954497327 0.9658243746143653 0.5433851932939868 0.0788331119451697 0.1546782956884947 8.198837345732349 0.026804826674737648 0.02670755438949037 2.1867674341367066e-07 6.6601974023495485 -0.1960837208353674 MQPQASAIPS(ph)PGKFR ddPTM_A459_Selumetinib_30min_R2 1 MQPQASAIPSPGKFR 15 1 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 MQPQASAIPS(1)PGKFR 91.547 0.0079313 4764100.0 34053.0 32774.0 31685.0 33623.0 27396.0 25849.0 19993.0 25857.0 19228.0 23245.0 True False 32160.470584959727 35287.6604149803 29646.421596019572 29043.489397089834 23954.269556652533 29409.465116140815 20922.714115377927 25932.23958914322 23074.13727520835 22573.856452236876 1.4246777307637615 1.5632092145905179 1.313307792966047 1.2865984799071348 1.0611509649375337 1.3028108501694042 0.9268559920032922 1.14877312363584 1.022161956422023 1.0 14.46236528497546 -5.809355258479954 0.6665088033393599 1.0406264487298895 1.5705046210340872 0.7299270800987936 0.10146527467650172 0.5691074466169489 0.4370216541049061 0.05445567691626719 0.19198741432040728 1.5511176566335003e-06 5.809355258479954 0.5298781723041976 MQQQLDEYQELLDIK ddPTM_A459_Selumetinib_30min_R1 1 MQQQLDEYQELLDIK 15 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 148.89 0.013528 0.0 1072.9 1104.9 1329.5 1580.9 1086.5 1176.5 1482.8 1129.3 771.44 1206.0 False True 1097.8964825000155 975.5377943459262 1148.9612024207534 1304.8254921683563 988.2262668371548 1164.665478176532 1370.951202190871 1099.347295516621 1309.077336251661 1360.8018474347875 0.8068011404964153 0.7168845311203004 0.8443266038965412 0.9588651680831042 0.726208792779077 0.8558670613006683 1.0074583634459462 0.8078672861805503 0.9619896818330818 1.0 10.410241289390953 -1.5228787452803594 0.08888521974537879 1.1053535699013344 0.16028358309394114 0.38087429991176913 0.08061566564717781 174.41279980390172 1.120819632442912 1.5848176142406145 20.105198313708467 0.029999999999998493 1.5228787452803594 -0.9450699868073933 MQRRGALFGMPGGS(ph)GGRK ddPTM_A459_Selumetinib_30min_R2 1 MQRRGALFGMPGGSGGRK 18 3 Q92995 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 MQRRGALFGMPGGS(1)GGRK 50.077 0.048028 2650300.0 15358.0 12693.0 17455.0 15276.0 15819.0 15023.0 14839.0 15220.0 12257.0 13247.0 True False 14504.463842945153 13666.512285572258 16331.964303567054 13195.38244743015 13831.675796345684 17092.281884784054 15529.042902920675 15264.287680193356 14708.742489194336 12864.524690160544 1.1274776326589757 1.0623410203429526 1.2695349961945028 1.0257186149693243 1.0751796999484067 1.3286368751623694 1.2071213882311636 1.1865411313539065 1.1433568548742687 1.0 13.65111053387604 MQS(ph)LQLDCVAVPSSR ddPTM_A459_Selumetinib_30min_R2 3 MQSLQLDCVAVPSSR 15 0 Q13546-2;Q13546 Q13546-2 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 1 MQS(1)LQLDCVAVPSSR;MQS(1)LQLDCVAVPSSR;MQS(1)LQLDCVAVPSSR 149.42 0.00028554 17672900.0 82407.0 80115.0 86153.0 114401.0 107432.0 66907.3 91686.0 93454.0 74241.0 87578.0 True False 77827.14884135827 86259.56288967322 80610.00977629417 98819.38644726753 93935.43170573429 76123.17325100263 95949.58067236237 93725.93566785748 89091.27446685768 85049.3955850291 0.9150817393352279 1.014228993590369 0.9478022650461214 1.1619058050620916 1.1044808850148884 0.8950466105887565 1.1281629929566717 1.1020176571878624 1.0475238989533755 1.0 16.376013362768155 -5.722523775937126 24.999744773757254 1.0644635300868752 0.9645566677719627 0.29039365247974624 0.07409774965436261 218.96131856307872 140661.2994903617 0.020346689765404737 0.035240649309172326 1.894419799386989e-06 5.722523775937126 -0.09990686231491253 MQSLS(ph)LNK ddPTM_A459_Selumetinib_30min_R2 1 MQSLSLNK 8 0 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 MQS(0.006)LS(0.994)LNK 87.363 0.032576 11651000.0 68873.0 72834.0 63779.0 75200.0 61116.0 44834.0 48389.0 49984.0 50553.0 52729.0 True False 65045.314380463744 78420.1336017783 59675.52857732473 64957.630272764356 53438.061696027755 51009.47653746978 50639.18438098445 50129.44516470336 60665.01256883754 51206.57676360498 1.2702531294123656 1.5314465164075435 1.1653879706276138 1.2685407691406727 1.0435780923752123 0.9961508806369715 0.9889195408386721 0.9789649754586369 1.1847113477024134 1.0 15.644041495534392 -5.90810617332485 1.2865748988059307 1.0222030516299987 1.3875000287635637 0.6572620350025693 0.0992886447928017 0.2594133366194838 0.86927928997254 0.03427984294178176 0.07147251674121827 1.2356453144568802e-06 5.90810617332485 0.365296977133565 MRDAGDPS(ph)PPNK ddPTM_A459_Selumetinib_30min_R1 1 MRDAGDPSPPNK 12 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2;A0A494C0S5;E9PMZ7;C9JMU2;A0A494C0B7;A0A494C0C1;C9JVK6;C9JD58;J3QTA0;Q9BTA9-3 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 MRDAGDPS(1)PPNK 132.24 0.0090721 20502000.0 2894.2 2640.7 3728.2 3370.8 2630.8 2552.0 2413.4 2798.5 1618.9 2269.5 True False 2961.6292288671284 2331.5256163718764 3221.930917536707 2782.153057752604 2392.844604505466 2526.3291970306054 2231.355294960513 2724.2746891908837 2747.1550602222 2560.8124318020336 1.156519388959324 0.9104632527620116 1.2581674774475564 1.086433751727304 0.9344083833666923 0.986534259853166 0.8713466348608427 1.0638321867540381 1.072766996171226 1.0 11.322385870428763 -6.166253801028644 6.797546398734052 0.9856408443849556 1.1015279396298985 0.25258820010463856 0.09683085347690862 0.3803428543186286 23.262207311209924 0.028755809510198644 0.03726800557439333 6.819400529501023e-07 6.166253801028644 0.1158870952449429 MRDAGDPS(ph)PPNK ddPTM_A459_Selumetinib_30min_R2 2 MRDAGDPSPPNK 12 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2;A0A494C0S5;E9PMZ7;C9JMU2;A0A494C0B7;A0A494C0C1;C9JVK6;C9JD58;J3QTA0;Q9BTA9-3 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 MRDAGDPS(1)PPNK;MRDAGDPS(1)PPNK 78.505 0.024098 35264000.0 123073.0 124738.0 131942.0 141411.0 143419.0 89396.0 98414.0 105830.0 91920.0 119773.0 True False 116233.09536025452 134305.0035041138 123452.99536758775 122150.57785241857 125401.42303787239 101709.48754390966 102990.44600364155 106137.9477789004 110306.56845939027 116314.8422823733 0.9992971926839713 1.154667803942565 1.0613692366781997 1.0501718908398472 1.0781205612043898 0.8744325792661375 0.8854454339852468 0.9125056243573213 0.9483447365350248 1.0 16.827675677188857 -6.753318851038909 24.999833305260534 0.9162585087928318 1.0720605282418911 0.6882599481210014 0.048480634042111934 94.72427995155125 291617.4393396442 0.015663032423532147 0.015402656845733755 1.7647417039774113e-07 6.753318851038909 0.15580201944905936 MREDYDS(ph)VEQDGDEPGPQR ddPTM_A459_Selumetinib_30min_R1 3 MREDYDSVEQDGDEPGPQR 19 1 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 1 MREDY(0.002)DS(0.998)VEQDGDEPGPQR;MREDYDS(1)VEQDGDEPGPQR;MREDYDS(1)VEQDGDEPGPQR 316.54 4.067799999999998e-117 38503000.0 3318.0 4017.64 4528.1 4019.2 4148.2 3922.45 4016.6000000000004 3900.06 2039.4 2925.05 True False 3395.3029442958823 3547.2528410498344 3913.208891072894 3317.322169728037 3772.996042424193 3882.993714299646 3713.6246282167867 3796.617739619725 3460.7128481173336 3300.508659899775 1.0287211136719108 1.0747594406122698 1.185638122577059 1.005094217758778 1.143155928740622 1.1764834195034528 1.125167363847958 1.1503129156264704 1.0485392418944368 1.0 11.68847266809191 -5.002457039507459 13.26750902972377 1.1121263059350759 1.0401942227945398 0.10747919162526998 0.06351383874545243 0.4467563464759331 2479.3077267343033 0.01520702971772581 0.051496065024488995 9.943584312127743e-06 5.002457039507459 -0.07193208314053612 MREDYDS(ph)VEQDGDEPGPQR ddPTM_A459_Selumetinib_30min_R2 3 MREDYDSVEQDGDEPGPQR 19 1 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 1 MREDY(0.018)DS(0.982)VEQDGDEPGPQR;MREDY(0.001)DS(0.999)VEQDGDEPGPQR;MREDYDS(1)VEQDGDEPGPQR 264.66 3.7618000000000004e-47 70693300.0 106221.0 111808.0 113285.0 122758.0 124832.0 100658.0 86064.0 90273.0 92765.0 116430.0 True False 100317.66205635357 120383.31408061637 105996.366435382 106038.14863063856 109149.48814776065 114522.72581765248 90066.14653258062 90535.67948450027 111320.59207066265 113068.36337853008 0.8872301593374113 1.0646949375007517 0.9374537958113672 0.9378233261911135 0.9653406566286821 1.012862682324794 0.7965636349670803 0.8007162815420356 0.984542348932599 1.0 16.786835792963096 -7.2455646702027625 24.97661741913365 0.8788485818643769 0.9691604260966997 0.162691279553007 0.07646929349310166 1144.9372739704775 1801399.86787 0.028496199418068437 0.021991271289695243 5.681137882066585e-08 7.2455646702027625 0.09031184423232286 MREDYDSVEQDGDEPGPQR ddPTM_A459_Selumetinib_30min_R1 3 MREDYDSVEQDGDEPGPQR 19 1 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 0 ;; 230.48 3.1681e-23 26628500.0 3819.7999999999997 4561.8 4477.5 5069.2 4730.200000000001 4188.1 4434.3 4002.8 2336.96 3433.8 False True 3908.793907963049 4027.702335276717 3869.4800931469895 4183.959380669131 4302.354245184641 4145.9715164905465 4099.817180924588 3896.6327410731733 3965.650435194804 3874.561678044422 1.008835123237967 1.0395246404516105 0.9986884748986633 1.0798536010867863 1.110410570972285 1.0700491722674321 1.0581370285461187 1.0056964025514987 1.0235094353166565 1.0 11.91981739487363 -7.760809930951871 24.996511666380183 1.010952181134453 1.0536547065098651 0.27924851891399105 0.031195319186090895 24.928500226528683 990090.1712811476 0.017586913024644366 0.00935011889990263 1.734562963414327e-08 7.760809930951871 0.04270252537541208 MREDYDSVEQDGDEPGPQR ddPTM_A459_Selumetinib_30min_R2 2 MREDYDSVEQDGDEPGPQR 19 1 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 0 ; 249.89 3.2505999999999993e-37 19859700.0 72750.0 54774.0 64917.0 64065.0 61931.0 54544.0 63484.0 58643.0 43158.0 56616.0 False True 68706.84624132434 58974.98967383082 60740.310896285395 55339.23648171071 54150.6741098353 62056.94089886591 66436.13179115954 58813.641421128756 51790.80593527367 54981.3489739661 1.2496391507937958 1.0726362807459622 1.1047439182521002 1.0065092529452864 0.984891697282216 1.1286907661769108 1.208339428387203 1.0697016810005382 0.9419704481932015 1.0 15.746654683529751 -4.754215019365058 4.651535214437575 1.063354021476878 1.2654410957775533 0.3741113242057481 0.0742915334888114 0.25210185445011024 12.498092060094482 0.01978483206878654 0.1710959900474861 1.761103907309257e-05 4.754215019365058 0.2020870743006753 MREEQLAR ddPTM_A459_Selumetinib_30min_R1 1 MREEQLAR 8 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3;H0YF21 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 0 98.458 0.0249 0.0 882.63 1355.5 1413.8 1862.5 1271.0 1068.1 1269.2 1248.2 617.46 882.04 False True 903.1935617009865 1196.7974298451463 1221.8137254475077 1537.2493384550326 1156.0382744132753 1057.3558837572054 1173.4632221612178 1215.0936812749899 1047.784522505898 995.2584257971647 0.9074965238074345 1.202499168883254 1.2276346462165149 1.544573046165124 1.1615458301569583 1.0623933004237598 1.1790537932108616 1.2208825866525523 1.0527763396392869 1.0 9.958927369911324 -6.5123560572537125 24.821977269648745 1.1205107319162562 1.2364289109992364 0.1049805245787182 0.15503809511688396 1161.0151484349835 2738724.8242647555 0.05166878546033503 0.05499741116449574 3.0735759037598274e-07 6.5123560572537125 0.11591817908298019 MRPNSNT(ph)PVNETATASDSK ddPTM_A459_Selumetinib_30min_R1 1 MRPNSNTPVNETATASDSK 19 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 MRPNS(0.008)NT(0.992)PVNETATASDSK 72.654 0.017199000000000002 4033800.0 1046.9 1702.4 1468.2 1640.9 1509.3 1417.9 1333.1 1292.4 847.72 1154.5 True False 1071.290733087209 1503.0822165757115 1268.8265042453174 1354.3476185078466 1372.7840814885583 1403.6372133501948 1232.5431937150317 1258.1213536931568 1438.5189249808902 1302.6913207823081 0.8223672914653829 1.1538283802129443 0.9740039593442185 1.0396535210617026 1.0538061162978787 1.0774902626258884 0.9461513821822731 0.9657862408552891 1.104266914219566 1.0 10.347279555264985 -4.73802653302996 24.93601964689234 1.0313078596806995 0.8223663804553064 0.5108074735525938 0.06233103547416301 1682.7142224159713 1792091.5294961655 0.015118697017857346 0.8895635354843194 1.827988532577421e-05 4.73802653302996 -0.20894147922539308 MRPNSNT(ph)PVNETATASDSK ddPTM_A459_Selumetinib_30min_R2 2 MRPNSNTPVNETATASDSK 19 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 MRPNS(0.039)NT(0.961)PVNETATASDSK;MRPNS(0.034)NT(0.966)PVNETATASDSK 79.36 0.0096374 15857800.0 121171.0 110033.0 120044.0 133592.0 120288.0 89794.0 103743.0 113707.0 78257.0 120273.0 True False 114436.80090594525 118472.17728814093 112320.49973402456 115396.53914094594 105176.3460516361 102162.30843122551 108567.25506285451 114037.86854479293 93910.5866832732 116800.40598321742 0.9797637254992778 1.014313060736824 0.961644771595772 0.9879806338817589 0.9004792848643733 0.8746742579465417 0.9295109391867533 0.9763482205804881 0.8040262008743945 1.0 16.83368576328622 -6.256827106973925 24.26501820798365 0.9117825054413922 0.9862188922433466 0.3147984376350974 0.05178755125064243 306.5842841639914 1612928.1714667832 0.014842283331073116 0.018487663085197253 5.535704422492131e-07 6.256827106973925 0.07443638680195441 MRPQPS(ph)S(ph)SPFK ddPTM_A459_Selumetinib_30min_R1 1 MRPQPSSSPFK 11 1 H0YLZ5 H0YLZ5 MOK 2 MRPQPS(1)S(1)SPFK 128.38 0.020583 3960100.0 904.94 1525.8 1002.9 646.25 817.44 855.61 764.73 1064.2 1624.8 1218.8 True False 926.0233412932832 1347.1586266748236 866.7116885353693 533.3945691149346 743.5026963307536 847.0033402317226 707.045800412345 1035.9739589912235 2757.1669293032487 1375.2448521173467 0.6733516143453032 0.9795772909825613 0.6302235468840094 0.3878542561302539 0.5406329608767821 0.6158927546085078 0.514123575393696 0.7533014629331084 2.0048552990823962 1.0 10.425472787289992 -8.119690282879933 6.612442251827528 1.49282657078197 0.6232778821215774 0.6303152822608835 0.26660897677035134 0.14266788348326345 7.068216659624778 0.1757439257116586 0.0653440598764439 7.59118747590479e-09 8.119690282879933 -0.8695486886603925 MRS(ph)PQPARPGSAAVPGAAFAPIPR ddPTM_A459_Selumetinib_30min_R2 3 MRSPQPARPGSAAVPGAAFAPIPR 24 2 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 MRS(0.579)PQPARPGS(0.421)AAVPGAAFAPIPR;MRS(0.791)PQPARPGS(0.209)AAVPGAAFAPIPR;MRS(0.991)PQPARPGS(0.009)AAVPGAAFAPIPR 81.665 0.00091198 91372000.0 124096.0 133253.0 147742.0 120481.0 140753.0 95759.0 104402.0 102821.0 96759.0 124021.0 True False 117199.24111564785 143473.07662407326 138236.44056932724 104071.27995868251 123070.34979221465 108948.93303634667 109256.8998686384 103120.19208706704 116113.50367234665 120440.19148474353 0.9730907902989658 1.1912391939550127 1.1477600530620047 0.864090953989105 1.0218378788263907 0.9045895036637128 0.9071465141474659 0.856194189131039 0.9640760467161417 1.0 16.877957381317373 -5.756221627781384 24.999999999967347 0.9268155518759398 1.112750964440129 0.5433033393123933 0.07243425393181151 88.57576991124216 424389.98412960203 0.019270201430009886 0.03213724182505713 1.7529856954483624e-06 5.756221627781384 0.18593541256418922 MRSPQPARPGS(ph)AAVPGAAFAPIPR ddPTM_A459_Selumetinib_30min_R2 1 MRSPQPARPGSAAVPGAAFAPIPR 24 2 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 MRS(0.407)PQPARPGS(0.593)AAVPGAAFAPIPR 49.106 0.018498 84087000.0 62061.0 61503.0 72072.0 76828.0 90890.0 65458.0 55735.0 59236.0 52629.0 77171.0 True False 58611.89806986712 66220.08233668566 67434.96598606027 66363.89386430763 79471.58563309046 74474.24533143803 58326.787936807305 59408.36695295227 63156.27057712398 74942.87271566241 0.7820876882081109 0.8836074724267441 0.8998182688020572 0.8855264211194048 1.0604288673935713 0.9937468718873057 0.7782833219925064 0.792715368389347 0.8427255092921581 1.0 16.193503659767934 -10.425938419814004 15.020085880331948 0.9999999980413583 0.8838513507461785 0.14619055384824997 0.08660947210633321 0.0 0.0 0.09268390885943757 0.022479149766034216 3.750261747939106e-11 10.425938419814004 -0.11614864729517982 MS(ph)ADMSEIEAR ddPTM_A459_Selumetinib_30min_R1 2 MSADMSEIEAR 11 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 MS(1)ADMSEIEAR;MS(0.976)ADMS(0.024)EIEAR 226.42 5.312899999999999e-07 35729000.0 3424.6 4046.5 3956.2 4128.2 4713.299999999999 3169.7 3893.1 3606.2 1923.01 3331.5 True False 3504.3865168883876 3572.7338988331844 3418.96976985106 3407.287365911445 4286.982847200703 3137.8156958573322 3599.4403326472075 3510.551861411528 3263.2075189065968 3759.130476558041 0.9322332754188134 0.9504149752483382 0.9095108007481449 0.9064030597392956 1.1404187414973628 0.8347184848796201 0.9575193931398066 0.9338733739899026 0.8680750879108818 1.0 11.876183275759006 -10.466628833965666 14.842711954663663 0.999999998305063 0.9391871229067655 0.056454775243892086 0.07678475746543945 0.0 0.0 0.0721188728009511 0.01749139589169447 3.4148463384315665e-11 10.466628833965666 -0.060812875398297495 MS(ph)ADMSEIEAR ddPTM_A459_Selumetinib_30min_R2 2 MSADMSEIEAR 11 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 MS(0.922)ADMS(0.078)EIEAR;MS(1)ADMSEIEAR 179.59 5.2586e-05 26426000.0 19019.8 21129.7 23535.0 27077.0 28342.0 23478.5 24473.4 25367.0 18710.0 26075.0 True False 17962.75565829198 22750.28004730609 22020.78372297052 23389.065889569687 24781.42457930522 26712.450258397315 25611.46159312211 25440.81377026708 22452.522801079056 25322.146999013832 0.7093693776831616 0.8984340880807656 0.869625459635319 0.9236604577992763 0.9786462648791325 1.054904635828772 1.0114253579729848 1.0046862839575912 0.8866753203017685 1.0 14.628112111863624 -3.800007643606977 0.619475792398289 0.9928556774502078 2.0906872903565412e-19 0.7372695932387756 0.048673395221691534 5.55112797211837 0.646977795615468 0.023057674740911423 5.163430947261936 0.00015848652984984618 3.800007643606977 -0.9928556774502078 MS(ph)DDEDDDEEEYGKEEHEK ddPTM_A459_Selumetinib_30min_R2 2 MSDDEDDDEEEYGKEEHEK 19 1 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 MS(1)DDEDDDEEEYGKEEHEK;MS(0.999)DDEDDDEEEY(0.001)GKEEHEK 127.1 0.0001954 28749000.0 59557.0 35713.0 53847.0 48786.0 41188.0 36182.0 65604.0 66702.0 38764.0 42775.0 True False 56247.060365560945 38452.072264605864 50382.54264418076 42141.26263945583 36013.59521460815 41165.74207250598 68654.7159918599 66896.0917768894 46517.88315665574 41539.97460720294 1.3540465755558704 0.9256643180022157 1.2128688840229704 1.0144749253686023 0.8669623791335557 0.9909910263972076 1.652738516117324 1.6104028086066708 1.1198341741063473 1.0 15.342212713833272 -7.238979929602692 24.919098798449717 1.396610800483484 1.0506815620152754 0.26202070013718437 0.22755327003522827 854.5628105646746 948151.6706854402 0.08548045904123587 0.06616512865326836 5.7679311857679595e-08 7.238979929602692 -0.34592923846820867 MS(ph)DS(ph)LWTALSNFS(ph)MPSFPGGSMFRRTK ddPTM_A459_Selumetinib_30min_R2 1 MSDSLWTALSNFSMPSFPGGSMFRRTK 27 2 Q9Y2H9 Q9Y2H9 MAST1 Microtubule-associated serine/threonine-protein kinase 1 3 MS(0.984)DS(0.751)LWT(0.167)ALS(0.162)NFS(0.616)MPS(0.113)FPGGS(0.104)MFRRT(0.103)K 42.041 0.038758 3523900.0 10156.0 6750.3 10764.0 11208.0 10982.0 7477.1 8201.1 7179.5 6490.4 10940.0 True False 9591.570177689217 7268.026304364486 10071.455958957069 9681.451065121571 9602.34297967433 8507.00265464414 8582.467400171354 7200.39115636979 7788.661356928039 10624.133774466394 0.9028096201820427 0.684105307656438 0.9479790233028119 0.9112696875475695 0.9038236136250661 0.8007243541200055 0.807827497503665 0.6777391276524505 0.7331102490112641 1.0 13.375057597249052 -6.911419140291102 5.4625281790972355 0.7812370258726561 0.8660719981834728 0.0750163860018429 0.10309179319907395 0.4469822161929612 21.488694245451224 0.03667315721313727 0.03223053052019005 1.2262551934162544e-07 6.911419140291102 0.08483497231081671 MS(ph)GFIYQGK ddPTM_A459_Selumetinib_30min_R1 1 MSGFIYQGK 9 0 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E9PDQ5;Q15052-2;Q15052;E7EUY6;F6SJA5 B1ALK7 ARHGEF7;ARHGEF6 Rho guanine nucleotide exchange factor 7;Rho guanine nucleotide exchange factor 6 1 MS(1)GFIYQGK 143.0 0.0020716 302640000.0 1261.9 1676.6 1432.0 1451.1 1460.7 1423.3 1586.2 1061.7 693.9 1034.6 True False 1291.2998147700334 1480.3028925698065 1237.542265412951 1197.6926255205901 1328.5799429075316 1408.9828942530023 1466.551656943053 1033.5402671123675 1177.4976195491895 1167.4009878574063 1.1061321929665533 1.2680329278174467 1.060083277541403 1.0259479287564932 1.1380664884873413 1.2069399537163183 1.2562535685657539 0.8853344119652318 1.0086488120164383 1.0 10.189084478807262 -7.767371658884019 24.99996333126743 0.9602437005078216 1.149363063067654 0.5356664252989296 0.07972264779693355 119.60307729095602 504023.0448047974 0.04451562067549043 0.02227181133288077 1.70855255066047e-08 7.767371658884019 0.1891193625598323 MS(ph)GFIYQGK ddPTM_A459_Selumetinib_30min_R2 2 MSGFIYQGK 9 0 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E9PDQ5;Q15052-2;Q15052;E7EUY6;F6SJA5 B1ALK7 ARHGEF7;ARHGEF6 Rho guanine nucleotide exchange factor 7;Rho guanine nucleotide exchange factor 6 1 MS(1)GFIYQGK;MS(1)GFIYQGK 121.68 0.0061852 339510000.0 1083680.0 1005790.0 1254050.0 1047290.0 1245200.0 842230.0 645920.0 634980.0 635070.0 1002750.0 True False 1023453.4039147554 1082930.8588754216 1173365.7883064023 904647.2953239796 1088766.8437707596 958239.5374972823 675956.5598661982 636827.6866734016 762101.7453383886 973798.0020426098 1.0509914805411285 1.1120692963056997 1.2049375597867165 0.9289886541422535 1.1180623101372098 0.9840229036076347 0.694144533515505 0.6539628191243058 0.7826076288304418 1.0 19.893263015045726 -7.103283156439312 3.9392831669716 0.755291731387207 1.081149695600469 0.6270198277416241 0.10836373074844385 0.14100922546303904 3.87186949994179 0.04197536565415696 0.0323298841847531 7.883459549267027e-08 7.103283156439312 0.32585796421326196 MS(ph)GGSTMSSGGGNTNNSNSK ddPTM_A459_Selumetinib_30min_R1 2 MSGGSTMSSGGGNTNNSNSK 20 0 A0A6E1WJ75;Q86U70-3;Q86U70-2;Q86U70 A0A6E1WJ75 LDB1 LIM domain-binding protein 1 1 MS(0.988)GGS(0.012)TMSSGGGNTNNSNSK;MS(0.999)GGS(0.001)TMSSGGGNTNNSNSK 286.69 9.454799999999999e-82 4109700.0 1246.83 1130.03 963.1400000000001 1131.95 1388.27 732.12 1201.43 845.77 559.75 1159.96 True False 1275.8787130911494 997.7255622633053 832.350878149323 934.2761818331146 1262.7012236189753 724.7555375117743 1110.805167823158 823.3374321518579 949.8548674775319 1308.8521649672107 0.9748073519999966 0.7622904931270831 0.635939566307074 0.7138133754445217 0.9647393780722427 0.5537336888845127 0.8486865037587998 0.6290530391356186 0.7257159310282592 1.0 10.354086438543199 -10.93868917829875 6.268332465683081 1.0000542343506076 0.7510174714118876 0.23323415200058073 0.13209418438106127 9.650681157268465e-05 8.99388444842268e-06 0.12328638308488654 0.0298948463952677 1.1516243040059159e-11 10.93868917829875 -0.24903676293872 MS(ph)GGSTMSSGGGNTNNSNSK ddPTM_A459_Selumetinib_30min_R2 2 MSGGSTMSSGGGNTNNSNSK 20 0 A0A6E1WJ75;Q86U70-3;Q86U70-2;Q86U70 A0A6E1WJ75 LDB1 LIM domain-binding protein 1 1 MS(1)GGSTMSSGGGNTNNSNSK;MS(1)GGSTMSSGGGNTNNSNSK 300.86 9.670299999999994e-176 4384400.0 25641.7 18482.0 23554.9 22835.7 23347.3 21119.4 19216.1 24337.4 19800.9 17630.3 True False 24216.636965857986 19899.509971003434 22039.403378636005 19725.43826622028 20414.20344648976 24028.405647174917 20109.686725979776 24408.21780472653 23761.63328337182 17121.267429979423 1.414418474852775 1.162268509173526 1.2872530301141667 1.1521015220918132 1.1923301548776926 1.4034244687458746 1.1745442799852315 1.4256081160199403 1.3878431243802127 1.0 14.06350188311473 MS(ph)LFDLFR ddPTM_A459_Selumetinib_30min_R1 1 MSLFDLFR 8 0 Q5VYD6;O00165-4;O00165-6;O00165;O00165-2;O00165-5 Q5VYD6 HAX1 HCLS1-associated protein X-1 1 MS(1)LFDLFR 97.068 0.020569 6362300.0 3007.2 2882.2 2609.8 2667.9 2456.1 2618.5 3028.0 2094.9 1317.7 2395.4 True False 3077.2619090074063 2544.7506841015716 2255.403494605251 2202.0013476854683 2233.946188659673 2592.160267407775 2799.5955221432155 2039.3364468057816 2236.0406589998092 2702.872923171884 1.1385152008538264 0.9414984560632794 0.8344467382352859 0.8146891882365557 0.8265080350274424 0.9590388971619926 1.035785107816991 0.7545069652821758 0.8272829402485425 1.0 11.400277969150524 -4.797522286802705 3.095849535685792 0.8769342324810654 1.1738116601448594 0.4477867796656104 0.08544719434818927 0.32584545498956125 4.747284647058229 0.022773510419042704 0.23539678930491187 1.5939610808986578e-05 4.797522286802705 0.296877427663794 MS(ph)LPDVDLDLKGPK ddPTM_A459_Selumetinib_30min_R1 1 MSLPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MS(1)LPDVDLDLKGPK 77.324 0.022216 4535600.0 2898.4 2363.4 3860.4 3949.8 3314.6 2954.5 3174.2 4308.9 2817.9 2681.9 True False 2965.927080695352 2086.6920292851482 3336.178883659326 3260.0415769286933 3014.7950152401613 2924.780412471366 2934.767538436917 4194.6139747202415 4781.770488726999 3026.147988918209 0.9800998138744744 0.6895538608576447 1.1024506719025156 1.0772908624650894 0.9962483745938326 0.9665027695875904 0.9698030463758123 1.3861232134320491 1.5801509067758421 1.0 11.563266826631084 -7.7592113300692525 24.961892012325393 1.3623528700526297 0.968380526667316 0.471899324778975 0.16964690275865932 43.8288798283506 491055.0218997948 0.08266712587831031 0.04474717703275845 1.740959506827603e-08 7.7592113300692525 -0.39397234338531373 MS(ph)LPLLAGGVADDINTNKK ddPTM_A459_Selumetinib_30min_R1 1 MSLPLLAGGVADDINTNKK 19 1 Q15398-1;Q15398;Q15398-3 Q15398-1 DLGAP5 Disks large-associated protein 5 1 MS(1)LPLLAGGVADDINTNKK 141.69 5.158100000000001e-05 7713600.0 2045.3 2951.2 2175.9 1994.9 2539.6 1906.4 3040.2 2156.0 1264.7 2614.6 True False 2092.951510538988 2605.6721320243414 1880.424731363157 1646.528163910844 2309.8936284027973 1887.2233468727065 2810.8752663209384 2098.815876325012 2146.103529966654 2950.209378360695 0.7094247363900494 0.8832160019341413 0.637386873337115 0.5581055283695657 0.7829592181983728 0.6396913252039608 0.9527714496937914 0.7114125159114076 0.7274410913706578 1.0 11.526601631815673 -7.240379439246544 24.798524964720144 0.8238573388757102 0.7042735794848561 0.2618100394046692 0.11740238024536466 1252.6782329130917 1475057.1922483773 0.04540809951918063 0.03513683875681084 5.7493740011807224e-08 7.240379439246544 -0.11958375939085408 MS(ph)PEPVPPPPPPQCPGCDR ddPTM_A459_Selumetinib_30min_R2 1 MSPEPVPPPPPPQCPGCDR 19 0 Q1L5Z9 Q1L5Z9 LONRF2 LON peptidase N-terminal domain and RING finger protein 2 1 MS(1)PEPVPPPPPPQCPGCDR 93.427 0.0020326 2654800.0 9995.5 9092.7 12246.0 11434.0 12174.0 11030.0 9837.0 9093.7 8820.3 11943.0 True False 9439.990125156806 9790.080852361376 11458.105692436666 9876.669475249835 10644.593283059132 12549.28237962911 10294.439991645713 9120.161161456928 10584.606459773258 11598.17455835942 0.8139203352783567 0.8441053204622744 0.9879231972912669 0.8515710317647526 0.9177817793220752 1.0820049583220126 0.8875913998229975 0.7863445334062112 0.9126096875429738 1.0 13.501610136381638 -5.0729887682661845 7.127106671977679 0.9214546755556606 0.8210494715768977 0.20604957403483082 0.07797440983526571 0.39253384154007465 33.02475029903741 0.02082605906196397 0.056730033937419676 8.453007060637821e-06 5.0729887682661845 -0.10040520397876296 MS(ph)PGETASFNK ddPTM_A459_Selumetinib_30min_R2 2 MSPGETASFNK 11 0 Q9P212-2;Q9P212 Q9P212-2 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 1 MS(1)PGETASFNK;MS(1)PGETASFNK 148.13 0.00065431 10607600.0 70089.0 64387.0 74715.0 82844.0 84303.0 60645.0 67414.0 77281.0 55285.0 68747.0 True False 66193.7339684974 69325.27586316399 69907.9182435412 71560.50428612881 73712.10346161769 68998.29826950218 70548.88457830678 77505.87491544167 66343.54479196445 66762.09548384283 0.9914867633913171 1.0383927490703386 1.0471198924614296 1.071873250345284 1.104101105985459 1.0334950958242546 1.0567206446565236 1.1609263363250628 0.9937307136804945 1.0 16.02674161730424 -4.6817661125295045 1.2899697175463987 1.0666676514770634 0.9465951014016992 0.14982140840250524 0.04634185300045748 2.802523721968172 3.4810739231681915 0.013126377059223806 0.47443401441487265 2.0808170006690577e-05 4.6817661125295045 -0.12007255007536421 MS(ph)PMGTASGSNSPTSDSASVQR ddPTM_A459_Selumetinib_30min_R1 6 MSPMGTASGSNSPTSDSASVQR 22 0 Q5QPB1;O76080 Q5QPB1 ZFAND5 AN1-type zinc finger protein 5 1 MS(0.961)PMGT(0.033)AS(0.001)GS(0.004)NS(0.001)PTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(0.999)PMGT(0.001)ASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR 338.87 2.6597999999999982e-183 94732800.0 9170.06 9607.789999999999 10826.24 10820.599999999999 9344.959999999997 8027.13 9665.19 8152.429999999999 4310.65 6998.030000000001 True False 9383.704556169341 8482.90548025961 9356.09607227954 8930.98533781827 8499.710017986687 7946.384360250896 8936.13693681089 7936.201073575281 7314.85821258065 7896.295317084631 1.1883679851571043 1.0742892887891076 1.1848716007412294 1.1310348687814344 1.0764174434556026 1.0063433599118172 1.1316872758642182 1.0050537315143608 0.9263658359831136 1.0 12.946960231463278 -7.0881944703826205 0.5886588481864296 0.9696162331921644 1.153470687402274 0.5944666907545387 0.052720392250875645 0.6165497273472254 0.4479912768062074 0.04735206008420408 0.04085488612236076 8.162168001994355e-08 7.0881944703826205 0.1838544542101096 MS(ph)PMGTASGSNSPTSDSASVQR ddPTM_A459_Selumetinib_30min_R2 9 MSPMGTASGSNSPTSDSASVQR 22 0 Q5QPB1;O76080 Q5QPB1 ZFAND5 AN1-type zinc finger protein 5 1 MS(0.601)PMGT(0.398)AS(0.001)GSNSPTSDSASVQR;MS(0.999)PMGT(0.001)ASGSNSPTSDSASVQR;MS(0.993)PMGT(0.001)AS(0.001)GS(0.005)NSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(0.999)PMGT(0.001)ASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR;MS(1)PMGTASGSNSPTSDSASVQR 327.25 1.4458999999999993e-143 155412900.0 219842.5 192850.8 239367.7 235761.80000000002 250595.9 171406.1 178098.9 188572.69999999998 163807.0 204040.1 True False 207624.53394925568 207641.83624694252 223967.04278584578 203650.6361282099 219113.80268622932 195015.73440534432 186380.85174627544 189121.41533710918 196572.97714999228 198148.9321531532 1.0478206049012597 1.0479079245627831 1.1302964913923295 1.0277654989874199 1.1058036008837633 0.9841876627152996 0.9406099226526137 0.9544407496020898 0.99204661369589 1.0 17.596225666918073 -6.85831966643393 5.951812577755831 0.9675029264808067 1.071115285111601 0.6978790311766295 0.0321019779810401 0.11224655522809153 5.7439489566035 0.011046432983556419 0.009761819787476908 1.3857354701020196e-07 6.85831966643393 0.10361235863079432 MS(ph)PNQLCSVPLQPGR ddPTM_A459_Selumetinib_30min_R1 2 MSPNQLCSVPLQPGR 15 0 Q86TB9-4 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 MS(0.96)PNQLCS(0.04)VPLQPGR;MS(0.999)PNQLCS(0.001)VPLQPGR 197.1 2.1221e-05 72460000.0 1691.83 2398.1000000000004 1940.11 2323.3 2336.0 1982.3200000000002 1923.04 1675.87 863.57 1455.38 True False 1731.2463472718814 2117.3293371535565 1676.653718261398 1917.5792687423254 2124.709212454298 1962.3796606025503 1777.9835445516132 1631.4204836070498 1465.4152173426924 1642.1921996016933 1.0542288215056603 1.2893310159840643 1.0209850702421208 1.167694785791472 1.2938249328974019 1.1949756314020472 1.0826890695150395 0.9934406484227266 0.8923530495992628 1.0 10.681407272426444 -7.654122974806843 2.4106336415978746 0.947626675570575 1.1733553175137341 0.5450755404587835 0.08534688643280516 0.2217666852581638 2.5836374690246466 0.051476280038941655 0.02467081111521547 2.217568404315872e-08 7.654122974806843 0.22572864194315911 MS(ph)PNQLCSVPLQPGR ddPTM_A459_Selumetinib_30min_R2 6 MSPNQLCSVPLQPGR 15 0 Q86TB9-4 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 MS(0.984)PNQLCS(0.016)VPLQPGR;MS(1)PNQLCSVPLQPGR;MS(0.997)PNQLCS(0.003)VPLQPGR;MS(0.972)PNQLCS(0.028)VPLQPGR;MS(1)PNQLCSVPLQPGR;MS(0.992)PNQLCS(0.008)VPLQPGR 134.13 0.00095692 56543100.0 75736.1 60675.5 71582.0 76387.2 83638.6 58439.3 66177.0 61188.0 57500.3 66805.1 True False 71526.9907576298 65329.11574751752 66976.49205258866 65983.13158472998 73131.17132942898 66488.78311585322 69254.36162723784 61366.046949781274 69001.9666926183 64876.26318250494 1.1025140359335361 1.0069802504459706 1.032372839726843 1.01706122313351 1.1272408079932403 1.024855314628897 1.0674838258241965 0.9458936741956147 1.0635934208865767 1.0 15.985403103492322 -7.715165140375498 24.99999880856728 1.0035567940806134 1.051693685074848 0.2145956378257654 0.04446774459545504 187.8104257650793 101465.56774247366 0.0200800610184976 0.011593176610145483 1.9267921116246963e-08 7.715165140375498 0.04813689099423457 MS(ph)PPPSGFGER ddPTM_A459_Selumetinib_30min_R2 2 MSPPPSGFGER 11 0 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 MS(0.977)PPPS(0.023)GFGER;MS(0.999)PPPS(0.001)GFGER 113.38 0.0071316 19141000.0 76137.0 59092.0 75213.0 89484.0 85827.0 54091.0 70402.0 55351.0 65064.0 69563.0 True False 71905.61034055961 63624.166389272505 70373.87746572273 77296.12483148988 75044.64495688482 61541.544260790455 73675.83249891653 55512.06224614867 78078.6180400538 67554.53544362015 1.0644083312595762 0.941819316371025 1.0417343114505697 1.1442033362215909 1.110875005861239 0.9109905627602454 1.0906126733771282 0.8217370141265805 1.1557864698102598 1.0 16.043765011311585 -6.746998590912982 24.999627776123727 0.9906080935586717 1.0576043103672192 0.09674052004690137 0.09811774054029367 583.2278468403118 1009670.8668439895 0.031556521173427554 0.03142464748350639 1.7906116637419826e-07 6.746998590912982 0.0669962168085475 MS(ph)PSGGAPQTTPTLR ddPTM_A459_Selumetinib_30min_R2 2 MSPSGGAPQTTPTLR 15 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 MS(0.974)PS(0.026)GGAPQTTPTLR;MS(0.993)PS(0.007)GGAPQTTPTLR 121.45 0.0016741 10822200.0 23048.0 17570.199999999997 21509.5 22197.3 21251.3 21490.3 21969.6 20268.5 17347.9 19426.6 True False 21767.084428454215 18917.777842902527 20125.602187772856 19173.9894475217 18581.52170496751 24450.39375547994 22991.229931936534 20327.477979369203 20817.964740825213 18865.70358163151 1.1537912876807637 1.0027602607581367 1.066782487103637 1.0163410744028836 0.9849365874198991 1.2960234241825963 1.2186786372665062 1.077483163636735 1.103482022324071 1.0 14.203478284881813 -6.718876151056443 24.99988376623817 1.1489487491319423 1.04220662497412 0.2255374457831445 0.08626335651211765 199.09775852888697 116941.09138227979 0.02876458879990754 0.02876441712650657 1.9103979743015544e-07 6.718876151056443 -0.10674212415782236 MS(ph)PSQFAR ddPTM_A459_Selumetinib_30min_R1 1 MSPSQFAR 8 0 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 MS(0.928)PS(0.072)QFAR 90.149 0.028672000000000007 10502000.0 3648.7 4117.4 4112.1 4477.6 4299.7 3558.9 3703.0 3345.3 1892.9 3171.1 True False 3733.7076108656984 3635.332893872668 3553.699406148462 3695.67121496175 3910.792894173692 3523.100697222657 3423.679728697596 3256.5717769341645 3212.1130480539878 3578.141574129733 1.043476769578018 1.0159835262406702 0.9931690327297304 1.0328465597006464 1.0929676238774497 0.9846174680999136 0.9568318239420964 0.9101293812630151 0.897704291880969 1.0 11.804994755409691 -7.167980584331422 2.738878031102556 0.9311399628255805 1.0321328618198304 0.5985100722977005 0.03586221707759099 0.18881997460656497 2.7568684069083664 0.015798237014857126 0.011408971324397717 6.792339979291016e-08 7.167980584331422 0.1009928989942499 MS(ph)PSQFAR ddPTM_A459_Selumetinib_30min_R2 1 MSPSQFAR 8 0 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 MS(0.994)PS(0.006)QFAR 110.53 0.011984 3887000.0 11065.0 12424.0 15741.0 12956.0 13135.0 9566.5 11084.0 11831.0 8278.1 11015.0 True False 10450.05159670453 13376.88085054359 14728.24119750495 11191.370449653381 11484.863871610125 10884.198538959385 11599.427962529327 11865.426251272509 9933.951309439475 10696.968329592997 0.976917129668845 1.2505300977227964 1.376861251122853 1.0462189009845555 1.0736559666010628 1.017503109628587 1.0843659254781273 1.1092326242050274 0.9286697878647872 1.0 13.38491435415738 -5.924634512338156 24.99974250385457 1.044145591753879 1.2072134460660713 0.3459095719988562 0.10315584322363039 42.74152870786358 14176.315555263902 0.029078224457420476 0.04312997403519746 1.189502852014652e-06 5.924634512338156 0.16306785431219217 MS(ph)PVDFHTPSSPK ddPTM_A459_Selumetinib_30min_R1 1 MSPVDFHTPSSPK 13 0 Q02297-2;Q02297-6;Q02297;Q02297-7;H0YBA3;Q02297-11;A0A494C0Q4;A0A494C1F5;A0A494C1F8 Q02297-2 NRG1 Pro-neuregulin-1, membrane-bound isoform;Neuregulin-1 1 MS(0.996)PVDFHT(0.003)PSSPK 133.04 0.0013627 12483000.0 2259.8 1840.8 2149.5 1574.0 2145.8 1803.8 1735.4 1934.0 740.25 1822.9 True False 2312.448943194644 1625.2782802352976 1857.609706358338 1299.1304476393145 1951.7127688717603 1785.6554097193603 1604.497380821444 1882.7040374826408 1256.1501842791292 2056.886971549647 1.1242469689291958 0.7901641182601405 0.9031170560426202 0.6316003094037573 0.9488672911381956 0.8681349215674489 0.7800610354455328 0.915317206790523 0.6107045266239168 1.0 11.00624680284917 -4.7574124929426596 24.995310701709407 0.8247186529815629 1.124247404392337 0.34744573062925044 0.1219265731350186 127.33227340747295 790256.7225958687 0.028028574989461628 0.20912367120729675 1.748185473099755e-05 4.7574124929426596 0.29952875141077406 MS(ph)QDDFQSPPIVELR ddPTM_A459_Selumetinib_30min_R1 1 MSQDDFQSPPIVELR 15 0 Q5JVZ5;Q96JJ3;H0YCM7;Q96JJ3-3;Q5JW01 Q5JVZ5 ELMO2 Engulfment and cell motility protein 2 1 MS(1)QDDFQSPPIVELR 111.7 0.0031901 3205700.0 455.67 907.87 643.59 479.62 703.22 623.27 662.68 629.48 359.67 530.83 True False 466.28622442052574 801.5761583426873 556.1940129868166 395.86337058244436 639.613875163575 617.0004696838818 612.6935140732714 612.7841455607928 610.3337207425523 598.9672012220633 0.7784837357858149 1.3382638593686669 0.9285884299708277 0.6609099292494991 1.0678612682941253 1.0301072720259565 1.0229166352067403 1.0230679481456397 1.0189768646718853 1.0 9.226333194575412 MS(ph)SDRALR ddPTM_A459_Selumetinib_30min_R1 1 MSSDRALR 8 1 Q8NEC7-3;Q8NEC7 Q8NEC7-3 GSTCD Glutathione S-transferase C-terminal domain-containing protein 1 MS(0.5)S(0.5)DRALR 94.262 0.012215 11366000.0 232.05 229.28 244.88 317.14 191.02 261.45 318.65 223.66 163.02 182.05 True False 237.45631350930057 202.43579101061982 211.6266410295555 261.75745245510285 173.74227472732017 258.82005037760666 294.6139739534131 217.72781024993148 276.63303349028536 205.4178908171669 1.155967051188592 0.9854827649398791 1.0302249730424635 1.2742680367995856 0.845799136755621 1.259968395878286 1.4342176953595323 1.0599262283523352 1.3466842269182084 1.0 7.682418028048022 MS(ph)SHTETSSFLQTLTGR ddPTM_A459_Selumetinib_30min_R1 1 MSSHTETSSFLQTLTGR 17 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 MS(0.516)S(0.483)HT(0.001)ETSSFLQTLTGR 110.61 0.0013977 9698500.0 990.16 1291.6 1433.4 1224.9 1133.6 1195.3 955.82 864.55 587.97 870.13 True False 1013.2288014840296 1140.3788715514504 1238.7521531026005 1010.9942092207087 1031.0660801533352 1183.276367245566 883.7217278649036 841.6193255458204 997.7421463702804 981.8196612839404 1.0319907427388602 1.1614952485878718 1.2616901065952026 1.0297147725669054 1.0501583140074773 1.2051870765127861 0.9000855887416712 0.8572035769228965 1.016217321483986 1.0 9.939314247243429 -7.270747550912008 24.822297498595645 0.931476908375848 1.123807601797931 0.5311297742348569 0.08254749147957073 475.24946091805066 1267352.0616938188 0.034902662317903906 0.023893549192791408 5.361081988833891e-08 7.270747550912008 0.1923306934220831 MS(ph)SPEDDSDTKR ddPTM_A459_Selumetinib_30min_R1 1 MSSPEDDSDTKR 12 1 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 MS(0.573)S(0.426)PEDDSDT(0.001)KR 77.64399999999998 0.023338 11123000.0 3585.2 3608.7 3708.9 3937.1 4294.6 3411.6 4561.6 3715.8 1884.0 3150.6 True False 3668.7281844151885 3186.1917263608857 3205.2517515293944 3249.559393520168 3906.154188273214 3377.282401484959 4217.514839434771 3617.2449133805558 3197.0103980842705 3555.010199442824 1.031988089651666 0.8962538917216768 0.9016153461477417 0.9140787821169882 1.0987743970145076 0.9500063887339281 1.1863580138520504 1.0175061984203269 0.8992971099169665 1.0 11.795637983652902 -6.241347215670227 24.787061791431316 1.030484849205123 0.9306912457453178 0.22164989185778428 0.08143282596885724 1051.9374067935591 1297741.3377024143 0.024027763783098205 0.03097282983592681 5.736576431909076e-07 6.241347215670227 -0.09979360345980526 MS(ph)SRLGAVPAT(ph)S(ph)GPTTFK ddPTM_A459_Selumetinib_30min_R2 1 MSSRLGAVPATSGPTTFK 18 1 G3XAG1;Q96ME7-3;Q96ME7 G3XAG1 ZNF512 Zinc finger protein 512 3 MS(0.969)S(0.08)RLGAVPAT(0.802)S(0.811)GPT(0.179)T(0.159)FK 70.335 0.037609 0.0 18012.0 17349.0 17164.0 17806.0 20571.0 14488.0 14593.0 16796.0 12559.0 19647.0 True False 17010.96514774894 18679.612514172633 16059.686926750199 15380.79208293672 17986.687072926678 16483.59049103052 15271.603415480915 16844.873579272513 15071.150927779376 19079.740060963555 0.8915721646833515 0.979028668864857 0.8417141363266121 0.806132160804709 0.9427113270650251 0.8639316069486366 0.8004094063485725 0.8828670372578348 0.7899033676362497 1.0 14.219753896002237 -5.273717458587273 24.902702571319097 0.8599663795244871 0.9353004192591029 0.1483758374433326 0.06519797030539723 1023.4001157276361 2075686.1611647669 0.0161424142186561 0.033983536078603424 5.324545485723099e-06 5.273717458587273 0.07533403973461583 MSAGGGT(ph)RGY(ph)SPRSPGAT(ph)S(ph)QAICELQEEVS(ph)RLR ddPTM_A459_Selumetinib_30min_R1 1 MSAGGGTRGYSPRSPGATSQAICELQEEVSRLR 33 3 Q7Z591-4 Q7Z591-4 AKNA AT-hook-containing transcription factor 5 MS(0.182)AGGGT(0.713)RGY(0.698)S(0.259)PRS(0.259)PGAT(0.944)S(0.944)QAICELQEEVS(0.999)RLR 43.554 0.007041800000000002 676460000.0 1588.2 2259.6 1473.9 1699.9 1040.9 1397.7 1371.8 1786.2 1604.7 2931.8 True False 1625.2019699007583 1995.0449815404584 1273.752475553176 1403.0443760750131 946.7507787858215 1383.6404070100625 1268.3240215574835 1738.8241736047023 2723.058697349164 3308.1250881503433 0.49127585160615855 0.6030742273581736 0.38503757917611375 0.4241207145100704 0.2861895344214973 0.4182551657330742 0.38339663336812807 0.5256222564960272 0.8231426033746793 1.0 11.69179807196518 -8.330971002070534 2.159918837121323 0.9951213957666346 0.4261026847391745 0.8634264797053155 0.07744678986981116 0.10918620723903139 0.9744349862549775 0.07994536094336963 0.022736016086812565 4.666905402947659e-09 8.330971002070534 -0.56901871102746 down MSCFS(ph)RPSMSPTPLDR ddPTM_A459_Selumetinib_30min_R2 1 MSCFSRPSMSPTPLDR 16 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MS(0.11)CFS(0.63)RPS(0.098)MS(0.125)PT(0.037)PLDR 56.9 0.047364 31603000.0 42440.0 36346.0 38994.0 35197.0 34580.0 29623.0 24232.0 20678.0 7150.1 32858.0 True False 40081.35470078086 39133.62132919007 36485.1684934571 30403.107881788375 30235.751250877653 33703.29935917981 25358.836014797074 20738.169556572815 8580.319790486128 31909.30416466333 1.2561024362658255 1.226401588929884 1.1434021972143513 0.9527975829525318 0.9475528233035246 1.0562216958808888 0.794716045324476 0.6499098021553997 0.2688971137135625 1.0 14.961689528149908 -6.997206854273692 0.8302269807725073 0.6009919960418694 1.1807899225432248 0.5504928775902855 0.18906352104870336 0.45899104562939397 0.6594679437354184 0.13796313206699967 0.10331073448356139 1.0064521819326766e-07 6.997206854273692 0.5797979265013554 MSCFSRPSMS(ph)PTPLDR ddPTM_A459_Selumetinib_30min_R1 1 MSCFSRPSMSPTPLDR 16 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MSCFSRPS(0.002)MS(0.741)PT(0.257)PLDR 91.926 0.0061569 147960000.0 1917.1 1960.9 2958.5 2771.9 2721.1 2026.2 2121.6 1761.0 988.5 1457.6 True False 1961.7646999727633 1731.3169164023222 2556.7519498772454 2287.839700007253 2474.976985449224 2005.8182676424042 1961.5660038900414 1714.2925594658375 1677.4123028165066 1644.6971582263236 1.1927817167802321 1.0526660836876567 1.554542693218064 1.3910401003395108 1.50482231520257 1.2195669321916511 1.1926609066470546 1.0423150249220148 1.0198912878438142 1.0 10.683606246405557 -7.507540116562521 1.7076191229684388 1.0113869394083617 1.3345098422783552 0.4909283948266988 0.1375604606434764 0.35403656968495323 2.0116413771215953 0.09561961503695768 0.04751073949791636 3.107848811894843e-08 7.507540116562521 0.32312290286999357 MSCFSRPSMS(ph)PTPLDR ddPTM_A459_Selumetinib_30min_R2 2 MSCFSRPSMSPTPLDR 16 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MSCFS(0.001)RPS(0.044)MS(0.695)PT(0.26)PLDR;MSCFSRPS(0.014)MS(0.981)PT(0.005)PLDR 89.353 0.0072708 166423000.0 82048.0 76691.0 90847.0 86578.0 82477.0 62126.0 52846.0 52750.0 41544.0 87339.0 True False 77488.10062416749 82572.95309956833 85002.00292673481 74785.92704461937 72115.5019062648 70683.29257632262 55303.44371236244 52903.49376676741 49853.960836345716 84817.29613602544 0.9135884324807552 0.973539087677851 1.0021777019443434 0.8817296760401523 0.8502452352478889 0.8333594183781164 0.6520302607108547 0.6237347354473977 0.5877805955567436 1.0 16.372070871994246 -6.758047682347109 1.3810010992589348 0.6873721598018666 0.9523457486710077 0.4268056831189 0.11282724959833719 0.340066198368298 1.3559133857204084 0.05092768570501689 0.04615535801647942 1.7456304849816227e-07 6.758047682347109 0.26497358886914113 MSDT(ph)GSPGMQR ddPTM_A459_Selumetinib_30min_R1 4 MSDTGSPGMQR 11 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 MS(0.017)DT(0.698)GS(0.286)PGMQR;MS(0.047)DT(0.681)GS(0.272)PGMQR;MS(0.003)DT(0.498)GS(0.498)PGMQR;MS(0.001)DT(0.5)GS(0.5)PGMQR 128.36 0.0065263000000000005 63889700.0 12978.099999999999 14150.9 15099.0 15743.0 14936.2 11252.1 13433.7 13165.8 7053.17 11425.599999999999 True False 13280.464479013373 12494.106049425065 13048.638732870222 12993.780582710107 13585.223347200294 11138.91409008937 12420.385193466085 12816.600215454473 11968.714346845023 12892.187054768581 1.0301172657979063 0.9691223061182414 1.0121353869158898 1.0078802399864302 1.0537563013542663 0.8640050010730563 0.9634040477928075 0.9941370041411127 0.9283695850827745 1.0 13.654209405500536 -6.729601079561735 24.99999909414631 0.9504552879967112 1.011565112689246 0.38741760687818827 0.040535765128841904 222.192539221119 174469.00261823612 0.013247765652309455 0.013246695989254898 1.863798339342666e-07 6.729601079561735 0.06110982469253479 MSDT(ph)GSPGMQR ddPTM_A459_Selumetinib_30min_R2 2 MSDTGSPGMQR 11 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 MS(0.158)DT(0.538)GS(0.304)PGMQR;MS(0.003)DT(0.595)GS(0.402)PGMQR 120.57 0.010971 11871900.0 83044.0 72195.0 79823.0 86633.0 89926.0 68879.0 85218.0 87103.0 81399.0 88035.0 True False 78428.74693147141 77732.12435648698 74687.27508471116 74833.43594973917 78628.69193135996 78366.45702869218 89180.8058562635 87356.45530932213 97681.07447808824 85493.20080760033 0.9173682373639602 0.9092199569345941 0.873604852540174 0.875314472295281 0.9197069613560415 0.9166396425495092 1.0431333136884418 1.0217941834452426 1.1425595667884318 1.0 16.383522067954964 -7.266736617328832 2.04577741716039 1.0631237920541483 0.8958011736905922 0.7913116495246925 0.03771380396984108 0.13950696816157304 1.1405212512121072 0.01827222333204531 0.011638664173304492 5.4108236882318824e-08 7.266736617328832 -0.1673226183635561 MSDTGS(ph)PGMQR ddPTM_A459_Selumetinib_30min_R1 4 MSDTGSPGMQR 11 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 MS(0.039)DT(0.029)GS(0.932)PGMQR;MSDT(0.005)GS(0.995)PGMQR;MSDT(0.009)GS(0.991)PGMQR;MS(0.169)DT(0.187)GS(0.644)PGMQR 150.51 0.00061227 46778800.0 12050.2 12843.4 13983.3 14586.9 13800.199999999999 11276.7 12475.5 11664.0 6330.2 10238.0 True False 12330.946214392477 11339.688757265327 12084.444664768806 12039.57174502535 12551.974346623198 11163.26663642439 11534.462990917333 11354.632829988372 10741.88706048463 11552.14702656498 1.0674159691732275 0.9816087633916802 1.046077810209632 1.0421934309994065 1.0865490473553567 0.9663369597663246 0.9984691992227088 0.9829023820314604 0.9298606601684432 1.0 13.49587338848225 -6.782844763580389 24.999922742520365 0.9758799283798915 1.0411897331968922 0.5522236547050016 0.031097091806690142 198.89237914368678 232290.21814800246 0.011007034767399294 0.009716362559928629 1.648751624342716e-07 6.782844763580389 0.06530980481700077 MSDTGS(ph)PGMQR ddPTM_A459_Selumetinib_30min_R2 3 MSDTGSPGMQR 11 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4;A0A0U1RQL3 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 MSDT(0.003)GS(0.997)PGMQR;MS(0.001)DT(0.255)GS(0.745)PGMQR;MS(0.019)DT(0.031)GS(0.95)PGMQR 121.21 0.0063424 139466500.0 150284.0 134156.0 157398.0 164139.0 172320.0 116742.0 119720.0 139316.0 120019.0 140087.0 True False 141931.81691451813 144445.33382047038 147271.18404198482 141782.9850444318 150671.62103965424 132822.15082163774 125287.2172206795 139721.38649499457 144026.15361104786 136042.32432026273 1.0432916198961046 1.0617676119707113 1.08253945805342 1.0421976083755726 1.107534892486489 0.9763296201037829 0.9209429333604724 1.0270435115918102 1.058686363458405 1.0 17.05369603464453 -6.773162320060182 24.971673213419848 0.9935620987037213 1.066583238719735 0.47062018705598085 0.03750482550983017 206.8277888785028 440572.7478481648 0.01394473274185991 0.012398635851671329 1.6859227842818122e-07 6.773162320060182 0.07302114001601367 MSDYS(ph)PNSTGSVQNTSR ddPTM_A459_Selumetinib_30min_R2 2 MSDYSPNSTGSVQNTSR 17 0 Q93075;H7C1W4 Q93075 TATDN2 Putative deoxyribonuclease TATDN2 1 MS(0.084)DYS(0.876)PNS(0.027)T(0.013)GSVQNTSR;MSDYS(0.477)PNS(0.477)T(0.044)GS(0.002)VQNTSR 180.39 1.0497999999999998e-09 2847300.0 19273.8 17247.5 20792.3 20619.6 23236.0 18835.1 17856.9 17743.6 15929.8 20989.0 True False 18202.63935513453 18570.327790546566 19454.54605494455 17811.174909205994 20316.8859475244 21429.464056985704 18687.281232776088 17795.230938388893 19116.2051158006 20382.993034028816 0.8930307401246594 0.9110697216814009 0.9544499192275515 0.8738252954053781 0.9967567527303741 1.0513404003626865 0.9168075170107851 0.8730430760919298 0.9378507407566028 1.0 14.31507829161772 -6.261042202832981 24.999974368823015 0.9584293219096798 0.9116176206538265 0.21912711715467847 0.04988475257452589 75.43417656636626 4748142.310767456 0.016748274582619658 0.02029942776824075 5.482236883587213e-07 6.261042202832981 -0.04681170125585332 MSES(ph)PTPCSGSSFEETEALVNTAAK ddPTM_A459_Selumetinib_30min_R1 7 MSESPTPCSGSSFEETEALVNTAAK 25 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 MS(0.195)ES(0.609)PT(0.195)PCS(0.001)GSSFEETEALVNTAAK;MS(0.151)ES(0.699)PT(0.151)PCSGSSFEETEALVNTAAK;MS(0.165)ES(0.644)PT(0.19)PCS(0.001)GSSFEETEALVNTAAK;MS(0.178)ES(0.643)PT(0.178)PCS(0.001)GSSFEETEALVNTAAK;MS(0.251)ES(0.655)PT(0.088)PCS(0.005)GS(0.002)SFEETEALVNTAAK;MS(0.05)ES(0.941)PT(0.009)PCSGSSFEETEALVNTAAK;MS(0.049)ES(0.902)PT(0.049)PCSGSSFEETEALVNTAAK 205.2 7.1755e-32 344811400.0 32305.4 36244.2 39517.4 42381.0 37234.4 33220.299999999996 37040.5 33734.5 19711.0 30435.800000000003 True False 33058.05296463416 32000.712214528532 34151.154133540316 34979.953939899475 33866.55509426723 32886.13394361903 34246.50526352235 32839.75147490081 33448.12736551964 34342.53139979746 0.962598026912749 0.9318099426624463 0.9944273977934466 1.018560732541276 0.9861403255342721 0.9575920179201753 0.997203871340839 0.9562414340573185 0.9739563742734733 1.0 15.06770876435643 -5.266630364546718 24.997230116604293 0.9845751733752993 0.9472039841285065 0.38314201699392525 0.019415322578868823 425.785129239353 2050383.5441622555 0.0053198410126138315 0.011654384576217572 5.412147641052676e-06 5.266630364546718 -0.037371189246792835 MSES(ph)PTPCSGSSFEETEALVNTAAK ddPTM_A459_Selumetinib_30min_R2 9 MSESPTPCSGSSFEETEALVNTAAK 25 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 MS(0.147)ES(0.555)PT(0.297)PCS(0.001)GSSFEETEALVNTAAK;MS(0.142)ES(0.68)PT(0.173)PCS(0.006)GSSFEETEALVNTAAK;MS(0.149)ES(0.548)PT(0.291)PCS(0.012)GS(0.001)SFEETEALVNTAAK;MS(0.142)ES(0.506)PT(0.319)PCS(0.023)GS(0.008)S(0.001)FEETEALVNTAAK;MS(0.277)ES(0.669)PT(0.053)PCS(0.001)GSSFEETEALVNTAAK;MS(0.158)ES(0.65)PT(0.191)PCS(0.001)GSSFEETEALVNTAAK;MS(0.038)ES(0.924)PT(0.038)PCSGSSFEETEALVNTAAK;MS(0.063)ES(0.874)PT(0.063)PCSGSSFEETEALVNTAAK;MS(0.048)ES(0.902)PT(0.048)PCS(0.001)GSSFEETEALVNTAAK 154.14 7.6947e-11 79872400.0 552791.0 499168.0 594419.0 623329.0 614646.0 420320.0 467574.0 534940.0 418358.0 562623.0 True False 522069.08921770344 537452.5805219052 556174.7286944725 538430.5148974987 537428.6744750417 478215.2647149335 489317.11748030444 536496.5868359157 502041.28989919065 546378.6121198907 0.9555079163734669 0.9836632851286885 1.0179291728433033 0.9854531325969106 0.9836195315000998 0.8752452129476834 0.8955641868590101 0.9819135942279404 0.9188523832426821 1.0 19.059541485164942 -6.568797737589312 24.984489460822882 0.9306148325959905 0.9873953850562454 0.3162717033494412 0.037209388509246495 141.93286707650176 77224.59337442847 0.012340710793481 0.012340715819936138 2.698996133567292e-07 6.568797737589312 0.05678055246025482 MSESPT(ph)PCSGSSFEETEALVNTAAK ddPTM_A459_Selumetinib_30min_R2 2 MSESPTPCSGSSFEETEALVNTAAK 25 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 MS(0.256)ES(0.343)PT(0.399)PCS(0.001)GSSFEETEALVNTAAK;MS(0.035)ES(0.425)PT(0.5)PCS(0.033)GS(0.003)S(0.003)FEETEALVNTAAK 76.31 0.00054032 34729000.0 109127.8 103761.2 117940.9 128729.5 127097.9 83176.0 89374.2 107035.3 79626.2 120751.8 True False 103062.91374919574 111719.3503951565 110352.71089834264 111196.32002922604 111130.72553235755 94632.73900344812 93530.2773916176 107346.75500235219 95553.66494191768 117265.38178314555 0.8788860973461554 0.952705297133257 0.941051052069346 0.9482450689058192 0.9476857009502379 0.8069963834548279 0.7975949591378947 0.9154172644136741 0.8148497321965102 1.0 16.839417648919735 -6.742735409050134 24.98741841135172 0.8573491967178374 0.9359845226555376 0.23080278911511531 0.0595701796020988 301.85709290233393 403262.7875410414 0.018755066855062754 0.01872408554579444 1.8082754699757564e-07 6.742735409050134 0.07863532593770017 MSIS(ph)EGTVSDK ddPTM_A459_Selumetinib_30min_R2 1 MSISEGTVSDK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 MS(0.115)IS(0.746)EGT(0.076)VS(0.062)DK 163.45 0.00063837 4177300.0 25168.0 19634.0 31455.0 26985.0 28790.0 16878.0 26081.0 26840.0 19828.0 25633.0 True False 23769.263315486638 21139.86466673959 29431.21954561453 23309.59644827852 25173.14281413442 19202.791296770643 27293.818178521065 26918.09995639882 23794.154040609083 24892.908687467723 0.9548608245790584 0.8492324031776329 1.182313401584589 0.9363950489246635 1.011257588664509 0.7714161305078118 1.0964495359380029 1.0813561522422919 0.9558607368607026 1.0 14.603447195798815 MSKPGS(ph)PGSVIPAQAHGK ddPTM_A459_Selumetinib_30min_R2 1 MSKPGSPGSVIPAQAHGK 18 1 Q8IZD2-6;Q8IZD2-5;Q8IZD2-2;Q8IZD2-7;Q8IZD2 Q8IZD2-6 KMT2E Histone-lysine N-methyltransferase 2E 1 MS(0.04)KPGS(0.948)PGS(0.011)VIPAQAHGK 95.236 0.0017340999999999995 13592000.0 110540.0 97331.0 124850.0 124150.0 123390.0 93765.0 88305.0 103240.0 83335.0 113990.0 True False 104396.62932668047 104795.97473150803 116817.28692640185 107240.55582930414 107888.64507940425 106680.27763607659 92411.35747303796 103540.41130769787 100004.32857444829 110698.81251841183 0.9430690984992892 0.9466765934284795 1.055271364423827 0.968759767061345 0.9746142946335564 0.9636984824776972 0.8347998986679985 0.935334435412093 0.9033911593027721 1.0 16.756280220648534 -7.022131945479371 24.62906890159198 0.9110292290541236 0.978709703659057 0.2544436448093462 0.047591623696874835 778.4481436179948 866277.6119601487 0.017645022343346407 0.01379228394178054 9.503160288691418e-08 7.022131945479371 0.06768047460493332 MSKPGSPGS(ph)VIPAQAHGK ddPTM_A459_Selumetinib_30min_R2 1 MSKPGSPGSVIPAQAHGK 18 1 Q8IZD2-6;Q8IZD2-5;Q8IZD2-2;Q8IZD2-7;Q8IZD2 Q8IZD2-6 KMT2E Histone-lysine N-methyltransferase 2E 1 MS(0.083)KPGS(0.365)PGS(0.552)VIPAQAHGK 69.986 0.010512 10599000.0 193460.0 183370.0 208400.0 233520.0 229210.0 144430.0 157500.0 157720.0 138320.0 188610.0 True False 182708.26768174028 197433.88937251878 194991.7708887643 201714.17315553065 200414.59063660135 164323.92149499868 164824.06208032914 158178.9390880483 165987.86498371238 183164.33923236805 0.9975100417879422 1.077905722259877 1.0645727858706797 1.1012742655087993 1.0941790933569722 0.8971392694870162 0.899869826032174 0.8635902586222175 0.9062236987797879 1.0 17.48277912295611 -6.765207539316032 24.999483352930593 0.9039955508666757 1.069448815088242 0.7669141808830737 0.04220589409158597 42.33661128030741 280875.7747072533 0.014259097098565798 0.013052269417887178 1.7170876344874022e-07 6.765207539316032 0.16545326422156625 MSPAS(ph)PIDDIER ddPTM_A459_Selumetinib_30min_R1 2 MSPASPIDDIER 12 0 B4DWJ3;Q96CJ1-2;Q96CJ1 B4DWJ3 EAF2 ELL-associated factor 2 1 MS(0.012)PAS(0.988)PIDDIER;MSPAS(1)PIDDIER 137.09 0.0013528 11838200.0 4999.8 5849.9 4421.1 4606.8 5166.700000000001 4198.8 5101.2 4783.8 2909.1000000000004 4108.1 True False 5116.285612082743 5164.99098845527 3820.738903363968 3802.30886034612 4699.372897254975 4156.563884205374 4716.412377000317 4656.9180840276385 4936.530227742538 4635.414651282632 1.1037384995681137 1.1142457313988303 0.8242496498790586 0.8202737287577954 1.0137977399615472 0.896697317694166 1.0174736742688752 1.0046389448113464 1.064959793052513 1.0 12.17848268254036 -7.476271542667547 21.880155732935492 1.0230910023636817 0.9585726522208116 0.08434207218143253 0.09590700073027686 282.4971250631581 132620.37173430822 0.04397144027820279 0.02964243243902134 3.339861498555564e-08 7.476271542667547 -0.0645183501428701 MSPAS(ph)PIDDIER ddPTM_A459_Selumetinib_30min_R2 2 MSPASPIDDIER 12 0 B4DWJ3;Q96CJ1-2;Q96CJ1 B4DWJ3 EAF2 ELL-associated factor 2 1 MS(0.011)PAS(0.989)PIDDIER;MS(0.028)PAS(0.972)PIDDIER 167.73 0.00041747 5896700.0 13626.3 14545.3 15024.3 16581.7 19162.6 13051.9 14454.2 13598.6 11966.3 12423.0 True False 12869.004796400806 15660.877739489031 14057.652895220986 14323.243854972023 16755.222872182436 14849.680751648342 15126.348940453949 13638.169674630582 14359.894366357685 12064.315711169658 1.0666999359512892 1.298115708708578 1.1652258803378142 1.1872404699846302 1.3888249672270874 1.2308763387135064 1.2538091096579418 1.1304553031552202 1.1902783970633892 1.0 13.558458467660168 -8.834920409396256 0.9577349670820094 1.0013965691185915 1.2292919722162254 0.37547996076855683 0.08379034906393601 1.113351638504477 1.8618535028424381 0.0799718136589855 0.026193196283069906 1.4624451636514484e-09 8.834920409396256 0.2278954030976339 MSPNETLFLES(ph)TNK ddPTM_A459_Selumetinib_30min_R1 2 MSPNETLFLESTNK 14 0 Q9HB90;Q9NQL2 Q9HB90 RRAGC;RRAGD Ras-related GTP-binding protein C;Ras-related GTP-binding protein D 1 MSPNETLFLES(0.761)T(0.239)NK;MSPNETLFLES(0.907)T(0.093)NK 186.08 8.193700000000001e-05 33330000.0 9486.599999999999 11262.4 9421.8 10009.6 9025.5 10193.4 9306.2 9381.4 6609.5 8313.8 True False 9707.61932228972 9943.792972252284 8142.371310242841 8261.611263462817 8209.145118581446 10090.863650866682 8604.225841535392 9132.574796918121 11215.838761219726 9380.957213269763 1.0348218312474424 1.0599976895946572 0.8679680681972529 0.8806789196070969 0.8750860847088462 1.0756752665487832 0.9172012669841781 0.9735227002207947 1.1955964094319123 1.0 13.195519424500764 -8.115732224337716 7.745251913745849 1.0967189187789723 0.9566327474090666 0.2959276991366703 0.08482708809712752 0.3404194577638573 20.55589420810104 0.05893298190887613 0.022100942423203013 7.660688011517297e-09 8.115732224337716 -0.14008617136990575 MSPNETLFLES(ph)TNK ddPTM_A459_Selumetinib_30min_R2 2 MSPNETLFLESTNK 14 0 Q9HB90;Q9NQL2 Q9HB90 RRAGC;RRAGD Ras-related GTP-binding protein C;Ras-related GTP-binding protein D 1 MSPNETLFLES(0.917)T(0.083)NK;MSPNETLFLES(0.983)T(0.017)NK 165.24 0.0002545 12914500.0 67914.0 53626.0 63908.0 58654.0 56222.0 46479.6 45484.0 52433.0 38483.1 51125.0 True False 64139.61176128252 57738.941765232674 59796.22885776931 50665.22401620638 49158.889728942835 52881.743000200346 47599.09612483616 52585.57134924955 46180.79530765399 49648.888411297485 1.2918640036800442 1.1629453067894733 1.2043820268927274 1.0204704604157389 0.9901307219953156 1.0651143397636922 0.9587142360674705 1.0591490168646722 0.9301476183129543 1.0 15.59947379717297 -5.763042360672809 4.326696938132192 1.0043892057303658 1.217914867805109 0.8109204178500529 0.047971523589358564 0.0792162660428641 3.500056964860053 0.012753193423098623 0.02115923640142489 1.7256695636047392e-06 5.763042360672809 0.21352566207474322 MSPNETLFLES(ph)TNKIYK ddPTM_A459_Selumetinib_30min_R1 1 MSPNETLFLESTNKIYK 17 1 Q9HB90 Q9HB90 RRAGC Ras-related GTP-binding protein C 1 MSPNETLFLES(0.929)T(0.071)NKIYK 97.589 0.0030416 18350000.0 1506.1 1445.0 1895.3 1917.2 1592.0 1785.9 1339.4 1331.9 1170.3 1001.5 True False 1541.189199639549 1275.8187282377255 1637.9286701376857 1582.3970103012023 1448.0038810904293 1767.9354674674596 1238.3679796428737 1296.5736853790745 1985.9136246698613 1130.0522804361028 1.363821149093016 1.1289908885855877 1.4494273393312267 1.400286551070481 1.2813600805545249 1.5644722798003547 1.0958501664763425 1.1473572575586581 1.757364379551953 1.0 10.142173803303576 -7.278447951883753 24.916451691439388 1.2624227684710252 1.3556881956773235 0.06125250942472504 0.21590941569731162 3183.417582502933 4663479.132961022 0.08833482508826969 0.05970772015034207 5.2668633194921e-08 7.278447951883753 0.09326542720629827 MSPNETLFLEST(ph)NK ddPTM_A459_Selumetinib_30min_R1 2 MSPNETLFLESTNK 14 0 Q9HB90;Q9NQL2 Q9HB90 RRAGC;RRAGD Ras-related GTP-binding protein C;Ras-related GTP-binding protein D 1 MSPNET(0.001)LFLES(0.027)T(0.972)NK;MSPNETLFLES(0.022)T(0.978)NK 289.87 3.2205e-66 117571000.0 7522.5 8624.599999999999 6339.5 6627.4 5653.4 6473.700000000001 6453.700000000001 6632.5 5192.9 6270.5 True False 7697.75961376304 7614.827822532237 5478.630720380869 5470.049001705713 5142.050968188837 6408.580455649309 5966.892213096319 6456.584554603728 8811.972025590123 7075.379754842317 1.0879641631242156 1.0762429843176584 0.7743232038720396 0.7731103052047584 0.7267526473995506 0.9057578077365166 0.8433317249173289 0.9125424752197799 1.2454415636926484 1.0 12.78859186804472 -8.134029567964115 6.28684956674331 1.1198300334151554 0.8778077695080787 0.3561710736434197 0.12664017585774018 0.26272616976860047 12.038978955164987 0.09418416505322118 0.03483907170489705 7.344638621328528e-09 8.134029567964115 -0.2420222639070767 MSPNETLFLEST(ph)NK ddPTM_A459_Selumetinib_30min_R2 1 MSPNETLFLESTNK 14 0 Q9HB90;Q9NQL2 Q9HB90 RRAGC;RRAGD Ras-related GTP-binding protein C;Ras-related GTP-binding protein D 1 MSPNETLFLES(0.091)T(0.909)NK 194.01 0.00027662 12100000.0 45405.0 35987.0 37586.0 35731.0 38665.0 28632.0 32334.0 26456.0 22639.0 31125.0 True False 42881.571870616266 38747.087183557 35167.75768054258 30864.376160586977 33807.557030514305 32575.798104582118 33837.59506860551 26532.98257997344 27167.43258651144 30226.34037753808 1.4186822266609092 1.2818980630665726 1.1634805021476098 1.0211086018049025 1.118479994873528 1.077728818563493 1.1194737651320514 0.8778099580884339 0.8987999290413673 1.0 14.883518696299301 -1.5228787481338204 0.3324073564558483 0.952408657322998 5.954756417596879 0.8052804995420031 0.06919854915132019 26.674638651892995 0.3793749618235493 0.06807678271669734 82.17863806365823 0.02999999980288839 1.5228787481338204 5.002347760273881 MSQPGS(ph)PSPK ddPTM_A459_Selumetinib_30min_R1 1 MSQPGSPSPK 10 0 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0;A0A2R8Y7M9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 MSQPGS(0.975)PS(0.025)PK 168.83 0.00025373 263920000.0 10029.0 13095.0 12416.0 13955.0 10448.0 10897.0 10296.0 10150.0 5145.7 8331.1 True False 10262.656186963042 11561.831312299662 10729.97539620614 11518.02121779329 9502.980244744225 10787.38607368437 9519.36443064284 9880.789028153471 8731.877072941736 9400.477836786044 1.0917164387966656 1.2299195331386017 1.1414287212313288 1.2252591216928201 1.010903957196417 1.1475359296599865 1.0126468670977093 1.0510943379375748 0.9288758746679948 1.0 13.198518377116244 -7.097755815533977 0.7632344019860715 0.975078048833202 1.172602883524366 0.5678814399953822 0.06280346102609698 0.46537728551509694 0.5535811822884038 0.04674917495790865 0.033137590727138955 7.984434903381424e-08 7.097755815533977 0.197524834691164 MSQPGSPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 MSQPGSPSPK 10 0 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0;A0A2R8Y7M9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 MSQPGS(0.022)PS(0.978)PK;MSQPGS(0.025)PS(0.975)PK;MSQPGS(0.01)PS(0.99)PK 196.02 0.00010538 540540000.0 32166.1 40481.0 42125.0 45338.0 33007.4 32138.4 35882.0 32414.2 17175.600000000002 27328.699999999997 True False 32915.50754566478 35741.46570089368 36404.65637606185 37420.56939966405 30021.88649792979 31815.116875332442 33175.39185123607 31554.47011983961 29145.738743808997 30836.604849080522 1.0674167181101408 1.1590596914225273 1.1805662962648547 1.2135113311859895 0.9735795054242158 1.0317321582917744 1.0758445040756581 1.0232796468441465 0.9451669172547722 1.0 14.912356310916792 -6.265304964294748 24.999838174495622 1.0139832231324324 1.1572348654568811 0.6954863252678262 0.047512077379965274 204.28325054162775 1321156.9986358122 0.015244391249005694 0.017930846595524387 5.428689916256171e-07 6.265304964294748 0.14325164232444876 MSQPGSPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 5 MSQPGSPSPK 10 0 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0;A0A2R8Y7M9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 MSQPGS(0.022)PS(0.978)PK;MSQPGS(0.015)PS(0.985)PK;MSQPGS(0.01)PS(0.99)PK;MSQPGS(0.003)PS(0.997)PK;MSQPGS(0.051)PS(0.949)PK 158.06 0.00048171 971756000.0 1071450.0 969630.0 1084610.0 1084940.0 1062640.0 782480.0 896370.0 949270.0 720450.0 890490.0 True False 1011903.0983541848 1043997.5031481453 1014827.3734340793 937169.3003741095 929141.6630778663 890259.5173537792 938052.981123458 952032.2185398923 864560.1310549105 864779.2399291191 1.1701288047075742 1.2072416345629615 1.173510332552917 1.0837092949304885 1.0744264202665441 1.029464487869469 1.084731151964685 1.1008962456336542 0.9997466302796231 1.0 19.72197236428689 -5.813917218291426 2.4108799065994106 1.054499056136384 1.1913389302926407 0.7725581895452736 0.03284169782504604 0.1336558398621196 1.5835403957559928 0.009657702459912074 0.017073237666568954 1.5349095269816548e-06 5.813917218291426 0.13683987415625665 MSS(ph)HTETSSFLQTLTGR ddPTM_A459_Selumetinib_30min_R1 1 MSSHTETSSFLQTLTGR 17 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 MS(0.431)S(0.538)HT(0.028)ET(0.002)S(0.001)SFLQTLTGR 73.346 0.016753999999999998 8672500.0 642.18 641.93 739.17 730.77 635.04 628.19 831.75 693.95 438.33 421.46 True False 657.1415445352403 566.7725371748395 638.7947739701755 603.1547377518303 577.6007441254183 621.8709789508838 769.010427854233 675.5441917327192 743.8139956434591 475.5584963680476 1.3818311512757848 1.19180403988871 1.3432517321187651 1.268308194172253 1.2145734931384706 1.3076645327551901 1.6170680026271151 1.4205280672977343 1.5640851784252452 1.0 8.893479001374777 -7.025160651998896 24.729057279715757 1.439307476189719 1.2762453750324105 0.09096320859987772 0.16344631275779056 1082.926433682073 1064346.9666247081 0.0575134212280383 0.044756164765953566 9.437117186866182e-08 7.025160651998896 -0.16306210115730857 MSS(ph)PEDDSDTKR ddPTM_A459_Selumetinib_30min_R1 3 MSSPEDDSDTKR 12 1 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 MS(0.065)S(0.93)PEDDSDT(0.005)KR;MS(0.362)S(0.638)PEDDSDTKR;MS(0.011)S(0.985)PEDDSDT(0.003)KR 93.228 0.010568 31009800.0 11433.300000000001 12679.5 14394.900000000001 14568.2 13347.2 11446.4 12802.5 11916.3 6922.5 10458.7 True False 11699.673644670915 11194.978245460374 12440.151645525762 12024.13734898288 12139.94811663955 11331.259608499658 11836.797117648122 11600.241014402476 11746.976900604226 11801.176021365023 0.9913989608738699 0.9486324265643373 1.054145080371984 1.0188931448199912 1.0287066386147625 0.9601805437005074 1.0030184361472627 0.9829733065078623 0.9954073118930966 1.0 13.526643015039188 -6.747840684111151 24.999663163806705 0.9881706512630254 1.0081666262566695 0.1153182356778335 0.02774826944763528 590.4515647843735 1085475.8229393647 0.009628220337503527 0.00957380520478556 1.7871430472979664e-07 6.747840684111151 0.01999597499364414 MSS(ph)PEDDSDTKR ddPTM_A459_Selumetinib_30min_R2 1 MSSPEDDSDTKR 12 1 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 MS(0.107)S(0.87)PEDDS(0.014)DT(0.008)KR 113.07 0.015013999999999996 0.0 12678.0 9854.0 15454.0 16179.0 17098.0 11470.0 11846.0 13726.0 9723.5 11780.0 True False 11973.407514055129 10609.770114396044 14459.706465042977 13975.392289668272 14949.99638194062 13049.8883857068 12396.862472403682 13765.940387538383 11668.471697289813 11439.880791884292 1.0466374372143223 0.9274371217157134 1.2639735263064118 1.2216379299671312 1.306831483117069 1.1407363960439765 1.0836531164903653 1.2033290064791802 1.019981930717992 1.0 13.481784398286957 -10.64986949171668 13.430943612619364 0.9999923139404073 1.140889777184598 0.11349324282558604 0.11200244933233054 0.0 0.0 0.1150511696555483 0.027904007343569598 2.2393939897532604e-11 10.64986949171668 0.14089746324419072 MSS(ph)PLADAK ddPTM_A459_Selumetinib_30min_R1 1 MSSPLADAK 9 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 MS(0.026)S(0.974)PLADAK 128.51 0.004305600000000001 18998000.0 7099.5 8054.7 8395.9 8752.6 7653.4 6608.7 7813.9 6800.0 4444.9 6736.0 True False 7264.904536777758 7111.651979471562 7255.7828953775115 7224.122716650486 6961.1513213175185 6542.222478219502 7224.491231993023 6619.641910487052 7542.670657348601 7600.631214196292 0.9558291057732848 0.9356659702405473 0.9546289894746268 0.9504635224450081 0.9158648966306421 0.8607472582014086 0.9505120072789845 0.8709331796184283 0.9923742442944168 1.0 12.891903520557264 -8.398679869280318 8.002978052179394 0.9996581224580582 0.9251205948767678 0.44364954352488684 0.03222316310756774 0.26184706093762555 15.155995088728215 0.03158866338361036 0.008165980148446113 3.993191433126637e-09 8.398679869280318 -0.0745375275812904 MSS(ph)PLADAK ddPTM_A459_Selumetinib_30min_R2 3 MSSPLADAK 9 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 MS(0.015)S(0.985)PLADAK;MS(0.01)S(0.99)PLADAK;MS(0.098)S(0.902)PLADAK 136.5 0.0026345 36604500.0 497525.0 518527.0 551797.0 610786.0 577464.0 477054.0 516104.0 515276.0 444856.0 553582.0 True False 469874.5522503768 558296.3535729084 516294.98177114857 527595.8931353798 504917.8097263398 542763.8582349588 540103.8586406747 516775.36785146606 533839.6303151711 537598.6492812309 0.8740248006177077 1.0385002907268281 0.9603725427164571 0.981393636015967 0.9392095951160121 1.0096079276996581 1.0046599993560128 0.9612661202597783 0.9930077596528831 1.0 19.036169987780944 -6.771368856660958 24.97774429409116 0.9919719678034843 0.9644871681942976 0.1519338161599284 0.04010421918957817 490.12620538756926 1232912.7490814873 0.013458492545921246 0.01200972946618149 1.6928993698783527e-07 6.771368856660958 -0.027484799609186705 MSSEGPPRMS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 MSSEGPPRMSPK 12 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 MSS(0.001)EGPPRMS(0.999)PK;MSSEGPPRMS(1)PK;MSSEGPPRMS(1)PK;MSSEGPPRMS(1)PK 120.29 0.019314 84765000.0 9224.3 10008.1 11428.3 12320.8 8847.2 8460.2 8507.5 8560.1 5286.8 8496.1 True False 9439.208242636672 8836.346999360538 9876.399631158396 10169.20357006001 8046.972322100021 8375.098069246995 7865.772425572456 8333.058340876503 8971.313467405476 9586.657194022138 0.984619357049983 0.9217339079226214 1.0302235107892384 1.0607663718695526 0.8393929353307633 0.8736202723999953 0.8204916757091556 0.8692350390992045 0.9358124824782129 1.0 13.226812129068922 -6.269043280029893 24.99399588941211 0.8789502089413591 0.995999062421127 0.45222911726461335 0.05831147054835886 509.0213749791042 1673148.881821983 0.018110931891220646 0.020927357507760477 5.382161434016363e-07 6.269043280029893 0.1170488534797679 MSSEGPPRMS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 MSSEGPPRMSPK 12 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 MSSEGPPRMS(1)PK 112.02 0.031103 29535000.0 40388.0 37156.0 31961.0 31979.0 29020.0 19554.0 24921.0 23104.0 17217.0 27996.0 True False 38143.39664597399 40005.745724629574 29904.664056505677 27623.40503314801 25374.248157908314 22247.386006461267 26079.875880024665 23171.22881492689 20660.8810831736 27187.682737656392 1.4029660789421876 1.4714658145256154 1.0999342733643909 1.016026459470491 0.9332994063066518 0.8182891576723988 0.9592533549724944 0.8522693544173774 0.7599353458158895 1.0 14.730665572274487 -5.497729064794992 1.3622624400236918 0.8794512415946333 1.485369136593298 0.8837543952214485 0.0765171724819655 0.15071309352424947 0.5057572152028319 0.023880791932997917 0.08721979922338484 3.1788565862059146e-06 5.497729064794992 0.6059178949986647 MSSPET(ph)DEEIEK ddPTM_A459_Selumetinib_30min_R2 1 MSSPETDEEIEK 12 0 D6REL5;Q6UWZ7-2;Q6UWZ7 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 MSSPET(1)DEEIEK 172.85 0.0004858 4515700.0 16592.0 20056.0 15303.0 20481.0 17536.0 11496.0 13782.0 14845.0 10971.0 18026.0 True False 15669.883063038547 21594.23070979573 14318.421640646602 17691.452468304327 15332.970906170936 13079.469649702292 14422.890308514918 14888.196492277953 13165.506555352138 17505.542542827352 0.8951383840119288 1.2335653497722445 0.8179364681566738 1.0106200607620213 0.8758923563013706 0.7471616271077196 0.8239042162349028 0.8504847225302469 0.7520764651048486 1.0 14.09552415492438 -5.923613087003054 1.1735428241135537 0.8260182922328132 1.040197817871703 0.2569668093425057 0.12016098373381767 0.5869373333913064 1.6316455524258264 0.04284138378876365 0.09239676349500758 1.1923037585369137e-06 5.923613087003054 0.21417952563888987 MSTSQNS(ph)IPFEHHGK ddPTM_A459_Selumetinib_30min_R2 3 MSTSQNSIPFEHHGK 15 0 P48730-2 P48730-2 CSNK1D Casein kinase I isoform delta 1 MSTSQNS(0.999)IPFEHHGK;MS(0.004)T(0.014)S(0.016)QNS(0.966)IPFEHHGK;MS(0.124)T(0.124)S(0.141)QNS(0.611)IPFEHHGK 102.69 0.0031976999999999995 13089200.0 66435.0 64321.0 82567.0 73357.0 87565.0 54190.0 57332.0 61704.0 48567.0 62100.0 True False 62742.80866037648 69254.21387538745 77254.72911215224 63365.65005211666 76564.30185896764 61654.180612157914 59998.05160120275 61883.5484243529 58281.757075361136 60307.011644822924 1.040389947190538 1.1483608951353603 1.281023997128934 1.0507177909147203 1.2695754568289959 1.0223385130616174 0.9948768802301168 1.026141848792226 0.9664175936723662 1.0 15.880038127564339 -6.9035036029157935 8.327641034982321 1.0004297330550647 1.1581075348417196 0.5276993348000176 0.0740888150750346 0.20248070377790758 15.518986131085754 0.025294423452652724 0.022310048323635766 1.2488100843937388e-07 6.9035036029157935 0.15767780178665491 MSVQPT(ph)VSLGGFEITPPVVLR ddPTM_A459_Selumetinib_30min_R1 1 MSVQPTVSLGGFEITPPVVLR 21 0 E5RI98;P06748-2;P06748;P06748-3 E5RI98;P06748-2 NPM1 Nucleophosmin 1 MSVQPT(0.885)VS(0.115)LGGFEITPPVVLR 214.42 5.1530999999999984e-18 22439000.0 1909.7 3120.3 2944.6 2945.9 2758.1 2373.8 3017.3 2432.0 1399.8 2046.1 True False 1954.192294370658 2754.973825411885 2544.7394935300103 2431.4538663917747 2508.630341982105 2349.921727237953 2789.7026317578348 2367.495459750662 2375.3583626530567 2308.736865701759 0.8464335296940241 1.1932818617571166 1.1022215356519274 1.0531533075566473 1.0865813160650453 1.0178386987915469 1.2083242023814966 1.0254505374440075 1.0288562537987833 1.0 11.172888038467164 -4.743700283018478 24.922097987197382 1.0825216402720692 0.8464327722144726 0.5121958081015437 0.06818503285244247 887.8147066274031 1247244.7785563897 0.01647939439184421 0.5115590530553412 1.8042624758725674e-05 4.743700283018478 -0.23608886805759666 MT(ph)LEAIRY(ph)S(ph)RGSLQILDQLLLPKQS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 MTLEAIRYSRGSLQILDQLLLPKQSR 26 3 Q9BV20-2;Q9BV20 Q9BV20-2 MRI1 Methylthioribose-1-phosphate isomerase 4 MT(0.999)LEAIRY(0.995)S(0.988)RGS(0.018)LQILDQLLLPKQS(1)R 51.56800000000001 0.014536000000000004 5195400.0 8091.4 7052.6 8983.2 9735.2 10140.0 8626.0 7267.5 6975.5 6042.1 6637.4 True False 7641.712380440577 7593.511742316781 8405.23069216863 8409.248965843291 8866.122547249845 9814.153200968341 7605.453150278054 6995.797550143814 7250.688830379469 6445.761015963733 1.1855407548487946 1.1780628731829337 1.303993534875405 1.304616932743354 1.3754966287598598 1.522574786229642 1.1799154718026619 1.0853330635153624 1.1248770800565258 1.0 12.65413498446577 -7.511679782677319 14.517719579671915 1.089567813540807 1.311481550921639 0.5626958781307188 0.09576543521420312 1.9348613909182935 2511.4430338128795 0.04655186250946726 0.02928527147157371 3.078365742294923e-08 7.511679782677319 0.2219137373808322 MT(ph)NNEDSLSPTSSTLSNLELDAAEKDR ddPTM_A459_Selumetinib_30min_R1 1 MTNNEDSLSPTSSTLSNLELDAAEKDR 27 1 Q9ULH7-4;Q9ULH7;Q9ULH7-5 Q9ULH7-4 MKL2 MKL/myocardin-like protein 2 1 MT(0.404)NNEDS(0.404)LS(0.148)PT(0.035)S(0.009)S(0.001)TLSNLELDAAEKDR 95.742 0.00011265 0.0 996.92 1123.9 1379.4 1622.8 1322.2 1320.9 830.66 1061.1 728.22 1012.9 True False 1020.1462963313586 992.313265513065 1192.0850565018334 1339.4084437287663 1202.60724345337 1307.6129452812404 768.0026474317975 1032.9561810614425 1235.7361529155662 1142.915581481507 0.8925823681649275 0.8682297114427092 1.0430210908110906 1.171922463418125 1.0522275336333131 1.1441028248002745 0.6719679562302163 0.9037904441922742 1.0812138472324793 1.0 10.158503131192836 MT(ph)QNIFNST(ph)TTAEEKIDS(ph)Y(ph)LEK ddPTM_A459_Selumetinib_30min_R1 1 MTQNIFNSTTTAEEKIDSYLEK 22 1 C9JVS4 C9JVS4 TTC27 4 MT(0.603)QNIFNS(0.379)T(0.565)T(0.251)T(0.495)AEEKIDS(0.787)Y(0.921)LEK 45.347 0.046144 0.0 229.4 129.07 313.45 208.95 0.0 155.13 240.23 191.36 0.0 171.29 True False 234.74457366530288 113.95842439698488 270.8852116576045 172.46080497727743 0.0 153.5695330467703 222.10925768971737 186.28451117511796 0.0 193.27674000589127 1.2145515992154443 0.5896127200485237 1.4015406698671948 0.8922998441096464 0.0 0.7945577571418544 1.1491773799731269 0.9638227091860087 0.0 1.0 7.594524215853138 -6.007673462828004 24.9477704285379 0.6601150610128894 1.0417140421549005 0.1727316866352182 0.41234261407525213 699.9217742323015 2275583.1856028386 0.11977937515456621 0.16936654755451983 9.824863768666755e-07 6.007673462828004 0.3815989811420111 MTDQEAIQDLWQWR ddPTM_A459_Selumetinib_30min_R1 3 MTDQEAIQDLWQWR 14 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 ;; 225.15 1.7018e-07 302146000.0 3082.7799999999997 3934.2200000000003 3864.8299999999995 4252.02 3687.7899999999995 3053.07 3225.6 3184.0699999999997 1830.1000000000001 3081.91 False True 3154.602775954325 3473.599693430743 3340.0073139915753 3509.484527300708 3354.230045632205 3022.3588877657653 2982.2903950545415 3099.6181202830144 3105.5460347845137 3477.5031688455633 0.907145909805617 0.9988775062953814 0.960461328666558 1.0091966439431777 0.9645512549585162 0.869117507883999 0.8575953062451359 0.8913343769322871 0.8930390236899398 1.0 11.763836114073943 -6.709315868190363 7.633537941931817 0.8927063423155535 0.9719961401071192 0.3426222005903876 0.04448791461072628 0.21872107582390696 27.243097039041874 0.01405166600860914 0.013969967525325163 1.952918555310081e-07 6.709315868190363 0.07928979779156575 MTEEEVEMLVAGHEDS(ph)NGCINYEELVR ddPTM_A459_Selumetinib_30min_R1 4 MTEEEVEMLVAGHEDSNGCINYEELVR 27 0 P60660-2;G8JLA2;F8VZU9;F8W180;F8VXL3 P60660-2 MYL6 Myosin light polypeptide 6 1 MTEEEVEMLVAGHEDS(1)NGCINYEELVR;MTEEEVEMLVAGHEDS(1)NGCINYEELVR;MTEEEVEMLVAGHEDS(1)NGCINYEELVR;MTEEEVEMLVAGHEDS(1)NGCINYEELVR 159.01 9.4496e-17 33047600.0 4642.26 5705.3 5908.2 6225.3 6464.700000000001 4669.49 5278.02 4884.49 3004.38 4209.12 True False 4750.415625734479 5037.320823677989 5105.8988914195525 5138.16821835389 5879.969026435488 4622.5191701577 4879.894702041717 4754.937458140424 5098.213428766675 4749.401552300758 1.000213516044612 1.0606222211802145 1.0750615283195197 1.0818559268514159 1.2380441960286654 0.9732845536967509 1.0274757036868665 1.001165600713838 1.0734433323071917 1.0 12.213530022964509 MTGSAPPPS(ph)PTPNK ddPTM_A459_Selumetinib_30min_R1 4 MTGSAPPPSPTPNK 14 0 Q9UBW7 Q9UBW7 ZMYM2 Zinc finger MYM-type protein 2 1 MTGS(0.004)APPPS(0.786)PT(0.21)PNK;MTGS(0.004)APPPS(0.992)PT(0.004)PNK;MTGS(0.009)APPPS(0.782)PT(0.208)PNK;MTGS(0.002)APPPS(0.769)PT(0.229)PNK 157.37 0.00010122 22878600.0 14130.000000000002 17227.1 14267.2 14981.500000000002 13270.7 12973.8 15226.3 14705.599999999999 7625.9 11805.9 True False 14459.201507806149 15210.143123338488 12329.792604119868 12365.262262584742 12070.367528132374 12843.295351267892 14077.767932235549 14315.55971747917 12940.59532630086 13321.302264204282 1.0854195198812897 1.1417910067403634 0.9255696147103649 0.9282322416639011 0.9060951616244532 0.9641171033089728 1.0567861649730723 1.0746366559031215 0.9714211921362658 1.0 13.701447503871089 -5.254861817076041 24.995533372101512 0.9789443469909518 1.113605274082383 0.5087961290723864 0.05315318805547175 476.2765549052153 1809897.1185703601 0.01565462165953372 0.03937005912567343 5.560811618843528e-06 5.254861817076041 0.13466092709143118 MTGSAPPPS(ph)PTPNK ddPTM_A459_Selumetinib_30min_R2 3 MTGSAPPPSPTPNK 14 0 Q9UBW7 Q9UBW7 ZMYM2 Zinc finger MYM-type protein 2 1 MTGSAPPPS(0.968)PT(0.032)PNK;MTGS(0.001)APPPS(0.789)PT(0.211)PNK;MT(0.012)GS(0.157)APPPS(0.786)PT(0.044)PNK 166.52 0.00023132 31227000.0 118415.0 113684.0 121393.0 137194.0 130841.0 103308.0 115171.0 111735.0 96776.0 111435.0 True False 111833.96835280299 122403.19724832573 113582.70654270498 118507.94052714917 114403.58384661899 117537.73926334779 120526.6797070071 112060.13035127489 116133.90414736641 108217.58200709906 1.0334177337788484 1.1310842007197692 1.0495771984191438 1.0950895254652342 1.0571626322154761 1.0861242423217081 1.113743972759441 1.0355076159798484 1.0731519037243693 1.0 16.72357538592859 -9.017873162503994 0.8748754518999479 0.9998682328821765 1.0797864808229327 0.35409634666947354 0.030593661070131135 1.7413934911150801 2.0798675060601863 0.02872053160433354 0.009289623845997247 9.596808693506443e-10 9.017873162503994 0.07991824794075619 MTGSPT(ph)LVK ddPTM_A459_Selumetinib_30min_R2 1 MTGSPTLVK 9 0 B7ZBM3;Q8IVH2-3;Q8IVH2-2;Q8IVH2 B7ZBM3 FOXP4 Forkhead box protein P4 1 MT(0.001)GS(0.14)PT(0.86)LVK 118.28 0.01699 5540100.0 47623.0 43957.0 46299.0 56451.0 50217.0 41429.0 37207.0 44045.0 36367.0 50621.0 True False 44976.304309973784 47328.36055596787 43320.17274653973 48762.27641659336 43908.29151432401 47135.4686949823 38937.19922427182 44173.16365795774 43641.41617887987 49159.4402008467 0.9149067631001855 0.962752227498976 0.8812177797295909 0.9919209050666428 0.8931812757617154 0.9588284264915299 0.7920594511489409 0.8985692977276197 0.887752504922304 1.0 15.585180866780352 MTIIPGSS(ph)NT(ph)EAT(ph)T(ph)STK ddPTM_A459_Selumetinib_30min_R1 1 MTIIPGSSNTEATTSTK 17 0 Q7Z5P9;Q7Z5P9-2;A0A2R8Y6K8 Q7Z5P9 MUC19 Mucin-19 4 MTIIPGS(0.009)S(0.993)NT(0.997)EAT(0.945)T(0.425)S(0.348)T(0.283)K 80.361 0.015344 10748000.0 0.0 0.0 0.0 135.86 0.0 0.0 65.869 0.0 0.0 0.0 True False 0.0 0.0 0.0 112.13460140805414 0.0 0.0 60.90044829856385 0.0 0.0 0.0 0.0 MTIIPGSS(ph)NT(ph)EAT(ph)T(ph)STK ddPTM_A459_Selumetinib_30min_R2 1 MTIIPGSSNTEATTSTK 17 0 Q7Z5P9;Q7Z5P9-2;A0A2R8Y6K8 Q7Z5P9 MUC19 Mucin-19 4 MTIIPGS(0.012)S(0.989)NT(0.995)EAT(0.8)T(0.469)S(0.401)T(0.332)K 72.797 0.024474 4363400.0 1077.9 685.18 818.29 455.33 645.39 425.23 400.22 515.64 0.0 455.17 True False 1017.9946331755822 737.7311027990544 765.6421122867873 393.3132685119387 564.3103383401946 483.8015726463907 418.8310230208848 517.1404270312028 0.0 442.0280594263133 2.3030090770635416 1.6689689422805414 1.7321120140664306 0.8897925372031831 1.2766391777765997 1.0945042115070551 0.9475213486774238 1.1699266958354955 0.0 1.0 8.787994142898933 -1.5228787453292165 0.3179628217753461 0.7111936794627636 15.990254279440753 0.6729664175178272 0.33231934304019006 32.558366341940726 0.46479058049928035 0.3036699602293896 288.6394028075606 0.02999999999662356 1.5228787453292165 15.27906059997799 MTIS(ph)QQEFGR ddPTM_A459_Selumetinib_30min_R1 2 MTISQQEFGR 10 0 H0Y3Y9;Q5VWC4;P55036 H0Y3Y9 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 MT(0.011)IS(0.989)QQEFGR;MT(0.002)IS(0.998)QQEFGR 113.52 0.0075762 19783400.0 2043.61 2575.8 2224.0 2999.6 2726.3 2275.91 2540.0 2857.9 1588.87 2234.9 True False 2091.222136827156 2274.2241385430666 1921.9930155575435 2475.7761694656215 2479.706646367359 2253.016411760943 2348.4057550342695 2782.09920823249 2696.1963435266193 2521.7711847694914 0.8292672029315418 0.9018360397955565 0.762159956131479 0.9817608292212784 0.9833194468014443 0.893426186074406 0.9312525137957476 1.103232214340174 1.069167718233354 1.0 11.300221662003745 -6.681592012371687 0.5604545813948079 1.0560832810421932 0.8310216802551523 0.5379251412716033 0.06723566941025713 0.7632435152414885 0.5195767677479612 0.059144498102373134 0.07671065175379989 2.081651326700354e-07 6.681592012371687 -0.22506160078704085 MTNNEDSLSPT(ph)SSTLSNLELDAAEKDR ddPTM_A459_Selumetinib_30min_R1 1 MTNNEDSLSPTSSTLSNLELDAAEKDR 27 1 Q9ULH7-4;Q9ULH7;Q9ULH7-5 Q9ULH7-4 MKL2 MKL/myocardin-like protein 2 1 MTNNEDS(0.006)LS(0.155)PT(0.829)S(0.01)STLSNLELDAAEKDR 174.19 3.9849e-22 63564000.0 2359.2 3153.9 3285.9 3305.0 3242.8 2775.9 3200.4 2568.8 1620.6 2493.8 True False 2414.1647697959147 2784.63992179167 2839.692828156714 2727.8437925336298 2949.489312562841 2747.9769663155394 2958.991251343177 2500.6670793616368 2750.039836059112 2813.903521669051 0.8579415574148636 0.9896003542225132 1.0091649576074897 0.9694162474041131 1.0481842358310025 0.9765711386883629 1.0515610178376222 0.8886825934523798 0.9773042376477575 1.0 11.458357149414315 -4.761451167844589 11.492631619206755 0.9898597936523373 0.8577025925962178 0.4568767704575307 0.043212602260575605 0.058088863649670905 325.4843932668727 0.010656100633116878 0.05972803511601266 1.732003766639824e-05 4.761451167844589 -0.1321572010561195 MTNNEDSLSPT(ph)SSTLSNLELDAAEKDR ddPTM_A459_Selumetinib_30min_R2 3 MTNNEDSLSPTSSTLSNLELDAAEKDR 27 1 Q9ULH7-4;Q9ULH7;Q9ULH7-5 Q9ULH7-4 MKL2 MKL/myocardin-like protein 2 1 MTNNEDS(0.015)LS(0.177)PT(0.759)S(0.044)S(0.002)T(0.003)LSNLELDAAEKDR;MTNNEDS(0.005)LS(0.014)PT(0.75)S(0.167)S(0.061)T(0.001)LSNLELDAAEKDR;MTNNEDS(0.022)LS(0.059)PT(0.729)S(0.162)S(0.014)T(0.014)LSNLELDAAEKDR 118.44 1.1343e-11 43379200.0 72900.0 74966.0 79954.0 76855.0 82038.0 62115.0 65246.0 63038.0 51918.0 78211.0 True False 68848.50984182204 80715.65114631774 74809.846687333 66387.21641773019 71731.65301097462 70670.7774261707 68280.0682824963 63221.43014349727 62303.050710124146 75952.84521341765 0.9064638677901619 1.0627074064114022 0.9849512085706208 0.8740583217283133 0.9444235144768833 0.9304559589255014 0.8989797299974499 0.8323773779093232 0.8202859357679182 1.0 16.212816389022088 -6.117756146233369 0.8668991175857758 0.8814346600465836 0.9933128094194359 0.2077066892871372 0.0640302994519493 0.8800501949883478 1.3768006952334078 0.031520180210833394 0.06249721806449035 7.625070330085148e-07 6.117756146233369 0.11187814937285234 MTNSPVLPVGS(ph)TTNGSR ddPTM_A459_Selumetinib_30min_R2 1 MTNSPVLPVGSTTNGSR 17 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 MTNSPVLPVGS(0.617)T(0.192)T(0.113)NGS(0.077)R 102.79 0.0034408 4554600.0 12786.0 15458.0 11933.0 18645.0 14185.0 11879.0 13391.0 11875.0 10252.0 12007.0 True False 12075.40530641338 16643.578894695966 11165.243771668043 16105.518835580999 12402.953484491023 13515.224423174466 14013.708033763116 11909.554283987927 12302.68646481361 11660.32671206745 1.0355975097950179 1.4273681437648975 0.9575412462596748 1.3812236340610553 1.0636883331626563 1.1590776791174602 1.201828077360827 1.02137397845487 1.0550893442875295 1.0 13.509320591696444 -7.764911165523788 24.946553198637105 1.028673698511287 1.179533579035178 0.19965111409419012 0.13711597628016245 135.16666845387118 971207.1385470995 0.06546124911017591 0.03343151347624793 1.7182598194396735e-08 7.764911165523788 0.150859880523891 MTSERAPS(ph)PSSR ddPTM_A459_Selumetinib_30min_R1 1 MTSERAPSPSSR 12 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MTSERAPS(0.978)PS(0.019)S(0.003)R 125.47 0.013636 11625000.0 1345.9 636.49 11787.0 9696.3 4021.1 1940.0 1259.9 1502.7 1521.2 613.68 True False 1377.2568513344868 561.969454903827 10186.390141356462 8003.0232270934475 3657.392214982866 1920.485361379066 1164.86472864869 1462.8435145424837 2581.3652959478704 692.4518057494035 1.9889569785206285 0.8115647186386314 14.710612430755779 11.5575165818684 5.281800386128918 2.773457077349416 1.6822322058760744 2.11255642977106 3.727862754512131 1.0 9.435569853678949 -6.640263480497432 3.711423018460724 2.27831965984003 7.436194601511669 0.27243900774973084 3.852669984659754 0.3488089446487434 9.151762683113404 1.4716001909716667 1.4628023932035186 2.2894782363388932e-07 6.640263480497432 5.15787494167164 MTSERAPSPS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 MTSERAPSPSSR 12 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 MTS(0.004)ERAPS(0.397)PS(0.574)S(0.025)R 127.07 0.012556 12351000.0 1441.1 757.6 12316.0 10612.0 3777.3 2122.0 1469.2 1378.6 1868.6 661.88 True False 1474.6748261075327 668.8998398013155 10643.554846945468 8758.813411911311 3435.643881936478 2100.654606621845 1358.3770611402945 1342.0350496760948 3170.8777228557665 746.8387452571618 1.9745558669425383 0.8956415880257935 14.251476526275471 11.72785084803729 4.600248586130156 2.812728477147391 1.8188358193341447 1.7969542397187586 4.2457327542158065 1.0 9.544652964875509 -6.521539791038367 5.7298580570562905 2.4620035388513006 7.379003537869361 0.2676461867136344 3.792235673169602 0.2479385857029867 30.06783947157116 1.3674601234238302 1.4409663972740347 3.009263440749342e-07 6.521539791038367 4.91699999901806 MVEPENAVTITPLRPEDDYS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 MVEPENAVTITPLRPEDDYSPR 22 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;A0A669KAX5;H0YDF9 A0A0G2JMS7 SCRIB Protein scribble homolog 1 MVEPENAVTIT(0.001)PLRPEDDY(0.291)S(0.709)PR;MVEPENAVT(0.001)IT(0.021)PLRPEDDY(0.188)S(0.789)PR;MVEPENAVTITPLRPEDDY(0.007)S(0.993)PR;MVEPENAVTITPLRPEDDY(0.003)S(0.997)PR 110.94 2.553e-05 78962000.0 5399.4 5942.8 5983.799999999999 5422.700000000001 6326.3 5086.2 5829.099999999999 6230.5 2460.42 5074.8 True False 5525.195514596494 5247.014213267232 5171.232826660624 4475.727241685965 5754.087281998981 5035.037445900107 5389.406293964667 6065.246900483763 4175.153038033175 5726.200012738031 0.9648974018206841 0.9163169644083613 0.9030828149832572 0.7816225824682395 1.0048701179139594 0.87929821429562 0.9411837312660822 1.0592097528887423 0.7291315407679569 1.0 12.483362348353465 MVEPENAVTITPLRPEDDYS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 MVEPENAVTITPLRPEDDYSPR 22 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;A0A669KAX5;H0YDF9 A0A0G2JMS7 SCRIB Protein scribble homolog 1 MVEPENAVTITPLRPEDDY(0.16)S(0.84)PR;MVEPENAVTITPLRPEDDY(0.432)S(0.568)PR 103.99 4.2334e-05 47625000.0 163267.0 90944.0 133355.0 137061.0 111271.0 69941.0 151194.0 123792.0 97909.0 106259.0 True False 154193.2737495849 97919.11236895021 124775.08448594577 118393.05535658725 97292.14220463879 79574.7378888159 158224.82058522734 124152.2142251313 117493.53580603155 103191.02657596178 1.4942507974380792 0.9489111177401578 1.2091660353247418 1.1473192901074092 0.9428352971468826 0.7711400935646157 1.5333195708519642 1.2031299459332292 1.1386022574311856 1.0 16.654957994837247 -1.5228787452899588 0.00968712984688316 2.87565522951321e-09 2.415103168055855 0.03171164735603238 0.22440158937619792 99380.43516859907 74.7030515836711 8064.177217356258 10736.903116718477 0.029999999999335388 1.5228787452899588 2.4151031651801995 MVHSLPTAVPESPRIHPTRT(ph)PKTPR ddPTM_A459_Selumetinib_30min_R2 1 MVHSLPTAVPESPRIHPTRTPKTPR 25 3 Q659C4-5 Q659C4-5 LARP1B La-related protein 1B 1 MVHSLPT(0.002)AVPES(0.002)PRIHPT(0.001)RT(0.498)PKT(0.498)PR 43.732 0.0382 4525400.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MVIQEIENS(ph)EDEEGK ddPTM_A459_Selumetinib_30min_R2 1 MVIQEIENSEDEEGK 15 0 Q07617;Q07617-2 Q07617 SPAG1 Sperm-associated antigen 1 1 MVIQEIENS(1)EDEEGK 174.95 4.6258e-09 0.0 11667.0 8476.4 8556.0 11416.0 10063.0 8944.1 11440.0 13750.0 7294.5 7085.4 True False 11018.594846701464 9126.512624078206 8005.516275068446 9861.121106301558 8798.795975638579 10176.068588544049 11971.982667929957 13790.010223564965 8753.603825359238 6880.826091919939 1.6013476724314324 1.3263687386018006 1.1634527843203617 1.4331304082632372 1.278741223524147 1.4789021627059675 1.7399048468887324 2.004121313247313 1.2721733856402033 1.0 12.748366065748096 -6.989735839244668 6.854977588684101 1.5910710606821472 1.3536877122219118 0.023090015448750223 0.2746032595261754 0.2886898574174238 68.16223045166186 0.09644704286785424 0.08230878095286943 1.0239156022545345e-07 6.989735839244668 -0.23738334846023545 MVIQEIENS(ph)EDEEGKSGR ddPTM_A459_Selumetinib_30min_R1 2 MVIQEIENSEDEEGKSGR 18 1 Q07617;Q07617-2 Q07617 SPAG1 Sperm-associated antigen 1 1 MVIQEIENS(1)EDEEGKSGR;MVIQEIENS(1)EDEEGKSGR 196.11 1.5097e-10 23567000.0 2320.49 3414.0 4065.1000000000004 4331.200000000001 2831.13 3087.59 3249.4 2789.5 1930.64 2508.39 True False 2374.552902112462 3014.2872928744587 3513.0817479959414 3574.837226693392 2575.0547913765995 3056.531647907418 3004.295141893051 2715.5133984270037 3276.1550716334477 2830.366290287684 0.8389560426368377 1.0649813429512265 1.2412109909770248 1.2630298908520559 0.9097955979100026 1.0799067450724713 1.0614510044873693 0.9594211914356122 1.15750215188595 1.0 11.466773055382097 -6.277011752654243 24.988322938598778 1.030250465185141 1.1093376727607154 0.07636410912639069 0.124963618593663 2305.29147635711 3699195.078509143 0.04051086093112589 0.04608860752573639 5.28430951454648e-07 6.277011752654243 0.07908720757557441 MVIQEIENS(ph)EDEEGKSGR ddPTM_A459_Selumetinib_30min_R2 3 MVIQEIENSEDEEGKSGR 18 1 Q07617;Q07617-2 Q07617 SPAG1 Sperm-associated antigen 1 1 MVIQEIENS(1)EDEEGKSGR;MVIQEIENS(1)EDEEGKSGR;MVIQEIENS(1)EDEEGKSGR 142.27 0.00016655 20318900.0 39897.9 47323.4 39704.1 42333.0 37906.0 33702.7 41435.5 27561.0 22715.8 38027.1 True False 37680.53444194827 50952.95261128577 37149.581432555504 36567.17237150177 33143.90939606042 38344.9410023505 43362.33285288561 27641.19794703084 27259.594732482743 36929.15881672862 1.0203464050981657 1.379748530535293 1.0059687960107837 0.9901978150376155 0.8974997118278929 1.0383377859389675 1.1742031024341344 0.748492487581645 0.7381591026149873 1.0 15.172472780334093 -5.738126970969197 0.4997914782530574 0.8822539530592244 1.2564017115510968 0.2656657379643689 0.15302654711415686 2.602764738347384 0.9703921407782939 0.12046536181412848 0.5199420337707483 1.827565828213875e-06 5.738126970969197 0.37414775849187243 MVIQGPS(ph)SPQGEAMVTDVLEDQK ddPTM_A459_Selumetinib_30min_R1 7 MVIQGPSSPQGEAMVTDVLEDQK 23 0 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQK;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQK;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQK;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQK;MVIQGPS(0.615)S(0.385)PQGEAMVTDVLEDQK;MVIQGPS(0.625)S(0.375)PQGEAMVTDVLEDQK;MVIQGPS(0.464)S(0.464)PQGEAMVT(0.073)DVLEDQK 151.05 4.4016e-08 31974200.0 11441.400000000001 14444.76 9836.08 10445.33 10503.11 11253.06 13227.47 13014.400000000001 6374.0160000000005 13080.67 True False 11707.962358911065 12753.560784013265 8500.394361719982 8621.249198627931 9553.10555497468 11139.864433360988 12229.7112884028 12669.215835270985 10816.239612290607 14759.701411015596 0.7932384289409182 0.8640798637359229 0.5759191276983348 0.5841072904221247 0.6472424671033601 0.7547486309612593 0.8285879875100596 0.8583653207114054 0.7328223865164462 1.0 13.849375915500312 -7.12187125113643 2.8885616596408608 0.844843493724337 0.6903566010370713 0.35573109410065407 0.10218414402789452 0.3596855384522879 5.770736831538822 0.046118188857357675 0.03449320395396492 7.55316111877554e-08 7.12187125113643 -0.15448689268726568 MVIQGPS(ph)SPQGEAMVTDVLEDQK ddPTM_A459_Selumetinib_30min_R2 5 MVIQGPSSPQGEAMVTDVLEDQK 23 0 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQK;MVIQGPS(0.583)S(0.407)PQGEAMVT(0.009)DVLEDQK;MVIQGPS(0.583)S(0.417)PQGEAMVTDVLEDQK;MVIQGPS(0.597)S(0.403)PQGEAMVTDVLEDQK;MVIQGPS(0.836)S(0.164)PQGEAMVTDVLEDQK 120.66 7.0052e-06 9615400.0 75975.8 64984.200000000004 80692.4 79891.9 79721.2 67283.7 77103.3 78007.5 65822.9 72365.2 True False 71753.36919122486 69968.27918286338 75500.73883524233 69010.48539878543 69705.91013942943 76551.4189343836 80688.75622729049 78234.48891016313 78989.31924549137 70275.8286486304 1.0210248754231268 0.9956236806924793 1.074348610142127 0.9819946164395796 0.9918902626954357 1.0892994135598215 1.1481722489637698 1.1132488995800385 1.1239898662800156 1.0 16.100740939613218 -6.855921219020273 5.437357590230546 1.1072383934273773 1.0139202520174322 0.4596703236968207 0.043729676983591176 0.16770257080552367 7.751836185849199 0.014968311758986956 0.013239569943102443 1.3934095443862627e-07 6.855921219020273 -0.0933181414099451 MVIQGPS(ph)SPQGEAMVTDVLEDQKEGR ddPTM_A459_Selumetinib_30min_R1 6 MVIQGPSSPQGEAMVTDVLEDQKEGR 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.615)S(0.385)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.611)S(0.389)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR 143.47 1.5224000000000002e-09 70839400.0 13996.73 15160.369999999997 21601.5 22122.600000000002 18763.48 16113.749999999998 15745.5 15029.119999999999 9251.5 13217.529999999999 True False 14322.826576104424 13385.386832535194 18668.134948545994 18259.303202633742 17066.326546961445 15951.660305114394 14557.804258225226 14630.498916138116 15699.119797174431 14914.128725144892 0.9603528868539571 0.8974970700076986 1.251708047622784 1.2242956688344093 1.1443059706322634 1.0695670259450185 0.9761082612677929 0.9809824754610987 1.0526340550290452 1.0 13.864392078266615 -7.092117200670804 4.750474213237359 1.0016704619019614 1.1010608851175725 0.15542402565709235 0.1023511172336899 0.4763495012005268 17.98946836020892 0.04487877039763074 0.034784393606497696 8.088775823632588e-08 7.092117200670804 0.09939042321561109 MVIQGPS(ph)SPQGEAMVTDVLEDQKEGR ddPTM_A459_Selumetinib_30min_R2 8 MVIQGPSSPQGEAMVTDVLEDQKEGR 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.499)S(0.499)PQGEAMVT(0.002)DVLEDQKEGR;MVIQGPS(0.718)S(0.282)PQGEAMVT(0.001)DVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVT(0.001)DVLEDQKEGR;MVIQGPS(0.5)S(0.5)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.584)S(0.416)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.548)S(0.452)PQGEAMVTDVLEDQKEGR 86.141 4.556e-05 24017200.0 89959.40000000001 103214.1 102714.09999999999 111156.6 105521.5 67601.6 64727.0 68668.7 51530.3 99767.2 True False 84959.81668401088 111130.2895843602 96105.58663265617 96016.87932416984 92264.94579582087 76913.1067737748 67736.93375411717 68868.51454828476 61837.79987688103 96886.66170968411 0.8768989991479796 1.1470133001109728 0.9919382599911597 0.9910226818618179 0.9522977071115116 0.7938461849809725 0.699135800107216 0.710815228154374 0.6382488444299466 1.0 16.564010444469268 -6.7443216915804465 2.3709000642486586 0.737016142814352 1.0104434075960687 0.5126165050038536 0.1088252755382503 0.20726900872996512 2.3903555473188463 0.03943612386035668 0.036832566158692195 1.8016827000322426e-07 6.7443216915804465 0.27342726478171664 MVIQGPSS(ph)PQGEAMVTDVLEDQK ddPTM_A459_Selumetinib_30min_R2 2 MVIQGPSSPQGEAMVTDVLEDQK 23 0 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.199)S(0.801)PQGEAMVTDVLEDQK;MVIQGPS(0.256)S(0.744)PQGEAMVTDVLEDQK 111.64 9.4693e-06 3778500.0 21510.2 20527.2 21487.0 24298.0 22643.0 17434.8 19651.2 25209.0 18888.8 19951.4 True False 20314.749196153083 22101.570234648927 20104.549813276713 20988.570483612057 19798.38390901165 19836.285442643504 20565.019738114086 25282.354016425405 22667.087797168475 19375.351242037366 1.0484841767450166 1.1407055262408183 1.0376353730123486 1.0832614191826675 1.0218335482897702 1.0237897210145064 1.0614011318409329 1.304872035639386 1.1698930003389696 1.0 14.241934843771283 -7.597485735844844 24.999752584695923 1.1790585949034598 1.059821167675304 0.24682564295116582 0.0764387317315944 43.79936209039315 14674.861117544167 0.03423592142082438 0.019766118787690065 2.526470689261479e-08 7.597485735844844 -0.11923742722815578 MVIQGPSS(ph)PQGEAMVTDVLEDQKEGR ddPTM_A459_Selumetinib_30min_R1 5 MVIQGPSSPQGEAMVTDVLEDQKEGR 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.255)S(0.745)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.196)S(0.804)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.383)S(0.617)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.244)S(0.756)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.382)S(0.618)PQGEAMVTDVLEDQKEGR 162.44 1.4118000000000001e-14 101067800.0 12788.34 12771.619999999999 18526.579999999998 19966.45 15329.51 13618.2 13394.33 13194.11 7273.82 10370.06 True False 13086.28344022206 11276.312793034946 16010.772195219468 16479.684324185506 13942.958527144803 13481.213272336288 12383.984904263056 12844.15934229064 12343.141281206643 11701.158213938303 1.118375053217707 0.9636920197867861 1.3683066156773778 1.4083806083875587 1.1915878985839274 1.15212639858827 1.0583554788201546 1.0976827342605116 1.0548649164066184 1.0 13.514363718486734 -7.058903209309296 2.4348237373513353 1.0592172026856426 1.2157023475764206 0.28314381607568107 0.1178669536867032 0.4717078782355668 5.534051631407867 0.0566486688228716 0.043261291411058195 8.731659481528506e-08 7.058903209309296 0.15648514489077803 MVIQGPSS(ph)PQGEAMVTDVLEDQKEGR ddPTM_A459_Selumetinib_30min_R2 5 MVIQGPSSPQGEAMVTDVLEDQKEGR 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 MVIQGPS(0.254)S(0.746)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.265)S(0.735)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.057)S(0.943)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.264)S(0.736)PQGEAMVTDVLEDQKEGR;MVIQGPS(0.216)S(0.784)PQGEAMVTDVLEDQKEGR 144.63 1.5941e-10 44748600.0 158811.3 193634.3 184387.1 201344.6 189818.2 119248.6 121777.6 116732.5 83966.5 184757.5 True False 149985.2037180046 208485.42817759226 172523.834731495 173921.1181411918 165971.5407197615 135674.0122189883 127440.49969773662 117072.17224889444 100762.14622003259 179423.07091736508 0.835930423836529 1.1619767018345823 0.9615476641292826 0.9693353104032689 0.9250289824556688 0.756168153433703 0.7102793361308062 0.6524923001836986 0.5615896869050887 1.0 17.453005883969723 -6.724040896670429 1.944938680121806 0.7007028219716677 0.995627494665858 0.45092213234049483 0.12892908788820923 0.2630399378577278 2.0502922073452714 0.049186077127962344 0.04631579045020315 1.887813568977435e-07 6.724040896670429 0.2949246726941903 MVISEPGLNWDIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 MVISEPGLNWDISPK 15 0 Q659A1;H0YK97;H0YNU9;H0YN09;H0YK14;H0YMX6;H0YL35;Q659A1-2 Q659A1 ICE2 Little elongation complex subunit 2 1 MVISEPGLNWDIS(1)PK 118.2 0.002052 5786400.0 2018.4 2559.6 2590.7 2499.7 1992.0 1900.8 1951.6 2075.2 1443.7 2170.2 True False 2065.424792877277 2259.920842074242 2238.8971696964613 2063.1743201804265 1811.823951716165 1881.6796777883126 1804.3892407578257 2020.158954800402 2449.853456323915 2448.766309538125 0.843455247171727 0.9228813845043866 0.914295970577426 0.8425362241158786 0.7398925510609067 0.7684194569563587 0.7368564463377322 0.8249700867460216 1.0004439569351944 1.0 11.257839385980438 -8.260670952661318 9.502500273954109 1.0005027538544111 0.8234535100035233 0.576608272479286 0.06034408360738929 0.0753543977472326 162.65765944129888 0.05576435161585495 0.017980390772949537 5.48692529578654e-09 8.260670952661318 -0.17704924385088783 MVMVVVITCLLSHY(ph)KLS(ph)ARS(ph)FIS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 MVMVVVITCLLSHYKLSARSFISR 24 2 Q969W9-3 Q969W9-3 4 MVMVVVIT(0.004)CLLS(0.097)HY(0.904)KLS(0.996)ARS(0.999)FIS(1)R 46.569 0.030291 24391000.0 59550.0 33810.0 31256.0 26485.0 22308.0 24714.0 49795.0 45052.0 19814.0 27472.0 True False 56240.44939753769 36403.118283715274 29245.022988959703 22877.697310826632 19505.469603949652 28118.12916864495 52110.56616692062 45183.09386123988 23777.353649416385 26678.811979171922 2.108056739612111 1.3644954772399571 1.0961891036149292 0.8575230909340037 0.7311221211490797 1.0539498232003996 1.9532566220566043 1.6935946734252711 0.8912448450845301 1.0 14.703406803571268 MVNHFIAEFK ddPTM_A459_Selumetinib_30min_R1 1 MVNHFIAEFK 10 0 P11142;E9PKE3;P11142-2;E9PN89;A8K7Q2 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 96.113 0.030973 9317900.0 8801.5 9804.8 10353.0 10737.0 9460.8 8962.9 8405.5 9436.1 5836.4 7728.2 False True 9006.557825262265 8656.849457872147 8947.119464958298 8861.984508451911 8605.072310439908 8872.741363662075 7771.4663676931295 9185.823975227475 9903.944526209672 8720.189749042724 1.0328396611152846 0.9927363631992607 1.0260234837138131 1.0162605130725226 0.9867987461378976 1.0174940705431437 0.8912038145209235 1.0533972584984022 1.1357487407079527 1.0 13.090143812671693 -7.984243774860717 24.997788207677583 1.0767739657314765 0.9954994311317946 0.2929865661734533 0.04855303827079302 240.12630249175427 380968.409944804 0.02552932698963866 0.012258422377100864 1.0369462017112901e-08 7.984243774860717 -0.08127453459968192 MVS(ph)QS(ph)FTQRFRLS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 MVSQSFTQRFRLSR 14 2 Q9Y5N1-5;Q9Y5N1-7;Q9Y5N1-4;Q9Y5N1;Q9Y5N1-2 Q9Y5N1-5 HRH3 Histamine H3 receptor 3 MVS(0.858)QS(0.863)FT(0.279)QRFRLS(1)R 89.913 0.012699 49299000.0 0.0 151.56 0.0 56.335 199.19 126.65 108.38 0.0 106.71 128.56 True False 0.0 133.81528474166757 0.0 46.49714978892043 181.17329966985082 125.37601598899928 100.20480934276141 0.0 181.07907620996411 145.06192828044473 0.0 0.9224700534999487 0.0 0.32053310155252185 1.2489376214522177 0.8642930469434602 0.6907726274604448 0.0 1.2482880819003612 1.0 7.180525121391238 -6.160069684363623 24.999999995944076 0.7856385306164358 0.3322424297145399 0.2814250834027414 0.40943037845545127 61.484621738085885 15150.433733392147 0.12049254263049705 0.15555520098259312 6.917199726552547e-07 6.160069684363623 -0.45339610090189597 MVSDINNGWQHLEQAEK ddPTM_A459_Selumetinib_30min_R1 1 MVSDINNGWQHLEQAEK 17 0 O43707;O43707-2 O43707 ACTN4 Alpha-actinin-4 0 103.01 0.0047121 18267000.0 2591.3 2666.8 2777.5 2675.3 2818.9 2564.6 2756.3 2690.8 1334.3 2707.2 False True 2651.6722482079317 2354.5698162383155 2400.330755715412 2208.1090766006723 2563.9309927172167 2538.802452470491 2548.3900718901377 2619.431243049787 2264.2096465837776 3054.695490361078 0.8680643476821621 0.7708034478945708 0.7857839720160397 0.7228573465238148 0.8393409427576525 0.8311147413814376 0.8342533911911812 0.8575097751364275 0.7412227024684999 1.0 11.576812855723457 -6.469272029456294 24.682313748242777 0.8419178951484096 0.7850820220165523 0.166360098746415 0.06819851919537412 550.5476331033016 253490.11420847388 0.02005059580529326 0.022735105713461445 3.394126077891495e-07 6.469272029456294 -0.05683587313185734 MVSQSQPGS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 MVSQSQPGSR 10 0 E3W994;J3KR49;O75122;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 MVSQSQPGS(1)R;MVSQSQPGS(1)R 129.74 0.0028969 21022000.0 3073.4 4287.7 4520.8 5250.5 4898.3 3584.6 3621.5 3440.3 2126.21 3224.2 True False 3145.00424020463 3785.6940907023486 3906.9001909768626 4333.598739091627 4455.249629865106 3548.542178556392 3348.3273393136224 3349.0520683306772 3608.0230777657907 3638.0574763675318 0.8644734891172755 1.0405811659914252 1.0738973247002574 1.191184792225594 1.224623211371996 0.9753947543730075 0.9203613084905975 0.9205605161781513 0.991744385899112 1.0 11.828952620453956 -6.973860267528518 24.90161050436601 0.9510224605062457 1.0844981097716961 0.28186056404843207 0.09348481774041639 277.00962146502445 263888.0068351457 0.035615005517038154 0.03140855482057369 1.0620372083569877e-07 6.973860267528518 0.1334756492654504 MVSQSQPGS(ph)R ddPTM_A459_Selumetinib_30min_R2 6 MVSQSQPGSR 10 0 E3W994;J3KR49;O75122;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 MVSQSQPGS(1)R;MVSQSQPGS(1)R;MVSQSQPGS(1)R;MVSQSQPGS(1)R;MVSQSQPGS(1)R;MVSQSQPGS(1)R 130.69 0.0027371 92880200.0 84536.4 86520.9 107678.6 110449.5 124489.1 78577.29999999999 92051.3 124641.9 84787.5 117113.9 True False 79838.20531402201 93156.77482145804 100750.6761075952 95406.08756398491 108849.66631132558 89400.60982129014 96331.86784619054 125004.58729342271 101747.36916068922 113732.5174085447 0.7019822222630568 0.8190865457310205 0.8858563795408068 0.8388637633094109 0.9570672380381842 0.7860602390444713 0.847003742123738 1.099110352445528 0.8946198631583702 1.0 16.795285270416976 -2.0169808643511 0.18699394266381622 1.0136916666520788 9.718745102464904e-17 0.4659922798566746 0.07854045067802387 44.32096328994918 0.60231033071272 0.17307477360851936 12.423015376581787 0.009616546493579669 2.0169808643511 -1.0136916666520788 MVVS(ph)MPNLQDIAMPELAPR ddPTM_A459_Selumetinib_30min_R1 2 MVVSMPNLQDIAMPELAPR 19 0 H0YAY3;E9PF32;A2RUS2-2;A2RUS2 H0YAY3 DENND3 DENN domain-containing protein 3 1 MVVS(1)MPNLQDIAMPELAPR;MVVS(1)MPNLQDIAMPELAPR 202.61 1.259e-15 44325000.0 2871.73 2927.9100000000003 3390.64 3232.31 3072.57 2789.04 2601.7400000000002 2718.96 1669.2600000000002 2162.43 True False 2938.635721586139 2585.108936051571 2930.209711452351 2667.847736473335 2794.6565860062915 2760.9847898457056 2405.4886571271086 2646.8443483732167 2832.6123020733253 2439.998954351915 1.2043594184107618 1.059471329461368 1.2009061340891598 1.0933806884281794 1.1453515506725194 1.1315516282993847 0.9858564295024574 1.0847727387966204 1.1609071786777432 1.0 11.252664814191384 -7.044408505389136 24.516122417139083 1.0640563751245105 1.1370534679813633 0.3001362880656613 0.06052281269257232 506.4581334250166 279593.0473909388 0.022207758398711523 0.017203163559730627 9.02799884015113e-08 7.044408505389136 0.07299709285685285 MY(ph)CRKY(ph)KATLVIQTEEMYWK ddPTM_A459_Selumetinib_30min_R1 1 MYCRKYKATLVIQTEEMYWK 20 3 Q6ZTR5 Q6ZTR5 CXorf22 Uncharacterized protein CXorf22 2 MY(0.954)CRKY(0.852)KAT(0.081)LVIQT(0.092)EEMY(0.021)WK 42.708 0.044413 0.0 1003.6 1144.4 1107.1 918.77 862.96 873.17 890.75 752.21 359.89 670.68 True False 1026.9819273343421 1010.4131159828737 956.7619008649987 758.3240669489027 784.9054203679624 864.3867025749269 823.5600103530605 732.2589472775683 610.7070446743883 756.7683109764209 1.3570625413863826 1.3351683749537389 1.2642732088379016 1.0020557890042652 1.037180612590976 1.1422078462292524 1.088259112343726 0.967613121026131 0.8069934163686413 1.0 9.563707868100094 -4.519330076570786 0.37510280902684595 0.9383177116804761 1.8421791034232549 0.7351911467841545 0.0856780820762952 4.137397142889224 0.3984587845300979 0.08146532983003239 1.7583943122726402 3.0246137589493795e-05 4.519330076570786 0.9038613917427788 MY(ph)ELYDPCT(ph)VMFFFS(ph)Y(ph)HR ddPTM_A459_Selumetinib_30min_R2 1 MYELYDPCTVMFFFSYHR 18 0 O14835 O14835 TXNL4A 4 MY(0.857)ELY(0.42)DPCT(0.727)VMFFFS(0.998)Y(0.998)HR 43.37 0.046523 0.0 3547.2 3581.5 9907.1 9745.8 11892.0 9583.6 5198.5 5372.2 8310.9 8511.0 True False 3350.0608245666795 3856.1895336624184 9269.687972034892 8418.405227557267 10398.020644171114 10903.653908741035 5440.240550632328 5387.832212584411 9973.312225948055 8265.265315766314 0.4053180020944166 0.46655362971913167 1.1215233411022636 1.018528130185831 1.2580383383866078 1.3192140230443532 0.6582051927909512 0.6518643995985116 1.20665360940363 1.0 13.012845415564648 -5.252598139481697 22.24650474194085 1.0217118316780245 0.43593525493054675 0.5503534488856466 0.21443046372844854 115.23754361041331 289953.65371181944 0.05979976102746332 0.15217780652594873 5.589871964408254e-06 5.252598139481697 -0.5857765767474777 MY(ph)RMQLLS(ph)CIALSLALVTNS(ph)APT(ph)SSSTK ddPTM_A459_Selumetinib_30min_R2 1 MYRMQLLSCIALSLALVTNSAPTSSSTK 28 1 P60568 P60568 IL2 Interleukin-2 4 MY(0.999)RMQLLS(0.996)CIALS(0.015)LALVT(0.047)NS(0.919)APT(0.205)S(0.205)S(0.205)S(0.205)T(0.205)K 59.429 0.005019600000000001 3499500.0 15887.0 14944.0 17857.0 17744.0 16128.0 14920.0 13745.0 14832.0 12079.0 16124.0 True False 15004.064140699933 16090.156747466459 16708.100061231555 15327.236589892682 14101.85645385063 16975.094569724977 14384.169735200803 14875.158664430217 14495.137515458788 15658.458224816828 0.9582082683543034 1.027569669788143 1.067033536849188 0.9788471106051042 0.9005903551539215 1.08408467334424 0.9186197982380905 0.9499759459622166 0.925706561102273 1.0 13.934654547420212 -5.984215257377104 24.49418353335661 0.9622295380136052 1.0193237567823923 0.1669254734789004 0.05435060216206905 323.6218927949419 502179.34729883075 0.015153737459491515 0.022467636231637913 1.037014293912424e-06 5.984215257377104 0.057094218768787064 MYASVLLITAMS(ph)LDR ddPTM_A459_Selumetinib_30min_R1 1 MYASVLLITAMSLDR 15 0 G3V4Q5 G3V4Q5 LTB4R 1 MYASVLLIT(0.093)AMS(0.907)LDR 117.7 0.0080069 75096000.0 1355.6 1636.9 1930.3 1606.7 1728.9 1461.2 1537.9 1354.9 809.55 1237.7 True False 1387.1828424615724 1445.2509870258361 1668.175862378925 1326.120006494337 1572.521300262087 1446.5016546634486 1421.8949648296066 1318.9636506645454 1373.7472228073875 1396.5708512189362 0.9932778141909736 1.0348569037971913 1.1944799369992078 0.9495544070226661 1.1259874849096128 1.0357524313220001 1.018133067569445 0.9444301730294208 0.9836573787920404 1.0 10.447673051340683 -7.411797981535289 2.596629728263575 0.9737740528867028 1.0600999710754495 0.22906260686790525 0.0648882373874809 0.4047787497108925 5.31149233861254 0.03178355062112789 0.018994050700289446 3.874378254134671e-08 7.411797981535289 0.08632591818874669 MYEEHLK ddPTM_A459_Selumetinib_30min_R1 1 MYEEHLK 7 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 127.12 0.007670399999999998 3499600.0 4582.4 5672.4 4512.3 5137.7 4659.6 4407.4 5107.9 4661.9 3134.0 4052.2 False True 4689.161004201763 5008.272770972786 3899.5544442897076 4240.4971415733835 4238.140002719197 4363.065557599019 4722.606990606119 4538.251268014646 5318.169101696442 4572.339341770519 1.025549648374525 1.0953414426658592 0.8528576190015912 0.9274239781011883 0.9269084566846886 0.954230478420601 1.0328645005550732 0.9925447191890456 1.1631177618669746 1.0 12.158716763569279 -7.6980376496484855 1.749051059608073 1.071251089448715 0.9627176542417875 0.23724870052357283 0.07398115913851204 0.5493751082586465 3.2557885152324744 0.05541641780121048 0.023352731177014883 2.0042982641716026e-08 7.6980376496484855 -0.1085334352069276 MYFPDVEFDIKS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 MYFPDVEFDIKSPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 MYFPDVEFDIKS(1)PK;MYFPDVEFDIKS(1)PK 86.455 0.012818 105735000.0 5808.5 6480.5 9117.6 9230.900000000001 4849.5 5974.1 6351.799999999999 7455.4 6451.2 4932.1 True False 5943.82674862647 5721.760047297287 7879.479999391842 7618.8966004534595 4410.863581248765 5914.005978048803 5872.67861213648 7257.658573447816 10947.215222994286 5565.1830777223195 1.0680379541186846 1.0281350976936865 1.4158527921451063 1.369028923945422 0.7925819365953389 1.0626795013667811 1.0552534445174102 1.304118565748637 1.9670898639105847 1.0 12.44221343332143 -8.00475649276915 21.10970331867182 1.534231446146377 1.1215124901537736 0.22599633511032557 0.273549995516054 32.10592851919801 142479.05646245432 0.1526809172129121 0.06960855571305609 9.891075279610959e-09 8.00475649276915 -0.41271895599260344 MYLQQDELEEEEDERGPT(ph)PPVR ddPTM_A459_Selumetinib_30min_R2 1 MYLQQDELEEEEDERGPTPPVR 22 1 A0A0A0MSX4;Q9Y6N7-4;Q9Y6N7-3;Q9Y6N7;Q9Y6N7-2;A0A087WZ85;A0A087WTM1;Q9Y6N7-5;H7C545;Q9Y6N7-6 A0A0A0MSX4 ROBO1 Roundabout homolog 1 1 MYLQQDELEEEEDERGPT(1)PPVR 95.307 0.00030122 3550000.0 21231.0 9226.5 13653.0 16948.0 10962.0 9135.8 24002.0 18948.0 11513.0 10578.0 True False 20051.06601442691 9934.14288212656 12774.580844262435 14639.653163069275 9584.855558476604 10394.173523464704 25118.14055906073 19003.13554298974 13815.921700097451 10272.585655055347 1.9519005913140646 0.967053789153636 1.2435604114895655 1.4251186268634135 0.9330518995244106 1.0118361503609874 2.445162435486686 1.8498882541454316 1.3449312728094271 1.0 13.32651173961047 MYPESTTGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 MYPESTTGSPAR 12 0 A0A590UJ15;A0A590UJK5;A0A5F9UN28;A0A590UJJ4;K7EKU4;K7EIR5;A0A590UJU4;Q5TG84;A0A590UJU1;A0A590UJY1;A0A590UK89;Q5TG78;A0A590UJX9;A0A590UJV4;A0A590UJ72;A0A590UJI8;Q13303-2;Q13303;Q13303-5 A0A590UJ15 KCNAB2 Voltage-gated potassium channel subunit beta-2 1 MYPES(0.003)T(0.017)T(0.023)GS(0.957)PAR;MYPESTTGS(1)PAR 164.48 0.00051055 7017900.0 1965.81 2159.12 2455.6 2463.81 2400.7 1898.27 1819.78 2133.5 1464.13 1444.72 True False 2011.6095481996044 1906.3292266523429 2122.1430076452802 2033.5518349416895 2183.5571088780084 1879.1751272912577 1682.5125294867164 2076.9126494153115 2484.5216741757536 1630.1638847645004 1.2339922182058456 1.1694095572039607 1.3017973391993365 1.2474523904910726 1.3394709141120822 1.1527522753104853 1.0321125042773098 1.2740514428188 1.5240931892775167 1.0 10.670801294426331 -6.78818575530266 24.962302682797507 1.203449556035906 1.2552793841810468 0.044674481645802566 0.14080322541880533 1056.2927119969188 985826.9320128777 0.05115016853659818 0.04512325512129778 1.628599303403948e-07 6.78818575530266 0.05182982814514081 MYPESTTGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 MYPESTTGSPAR 12 0 A0A590UJ15;A0A590UJK5;A0A5F9UN28;A0A590UJJ4;K7EKU4;K7EIR5;A0A590UJU4;Q5TG84;A0A590UJU1;A0A590UJY1;A0A590UK89;Q5TG78;A0A590UJX9;A0A590UJV4;A0A590UJ72;A0A590UJI8;Q13303-2;Q13303;Q13303-5 A0A590UJ15 KCNAB2 Voltage-gated potassium channel subunit beta-2 1 MYPEST(0.003)T(0.033)GS(0.964)PAR;MYPESTT(0.001)GS(0.999)PAR 177.16 0.00010362 18681500.0 51262.0 54770.0 58585.0 62173.0 60062.0 43350.0 48058.0 51336.0 44008.0 54917.0 True False 48413.063258044975 58970.68288669287 54815.70488252509 53704.93014559276 52516.47459890728 49321.06900788052 50292.79222512041 51485.37926086772 52810.82968625805 53331.40351849823 0.9077777831452101 1.1057403142641584 1.0278316576369873 1.00700387768653 0.9847195298487076 0.9248035070138984 0.9430239766271318 0.9653857926879759 0.9902388874491252 1.0 15.702697675365838 -6.3161743744626255 2.819472719583091 0.9609872466344728 1.0214272458222777 0.15729662728317095 0.04933180047852215 0.4055728069210693 6.377843461972956 0.015797641987544978 0.01907460360293715 4.828648870477827e-07 6.3161743744626255 0.06043999918780496 MYS(ph)EGSDIVPQS(ph)NETALHY(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 MYSEGSDIVPQSNETALHYFK 21 0 Q9UBV2 Q9UBV2 SEL1L Protein sel-1 homolog 1 3 MY(0.409)S(0.496)EGS(0.095)DIVPQS(0.998)NET(0.053)ALHY(0.948)FK 69.081 0.006329100000000001 11765000.0 852.18 884.81 745.95 800.48 602.53 775.98 683.39 858.31 489.29 759.44 True False 872.034135946372 781.216033862991 644.6540872100493 660.6911948705961 548.0312678853115 768.1743457334679 631.8413420995544 835.5448306161971 830.289393672321 856.9215215720366 1.017635937473727 0.9116541179054967 0.7522906952172479 0.7710054867784709 0.6395349563399215 0.8964348851038768 0.7373386315942108 0.9750540855636074 0.9689211587884285 1.0 9.743019275532397 -7.780630798220086 23.857167618776085 0.9789909772629032 0.8134078741807045 0.35758219610002084 0.10018223080053819 173.3616301824233 215503.5645672442 0.05762275169519286 0.027763445855403423 1.6571781626549097e-08 7.780630798220086 -0.1655831030821987 MYS(ph)FDDVLEEGK ddPTM_A459_Selumetinib_30min_R1 1 MYSFDDVLEEGK 12 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 MYS(1)FDDVLEEGK 118.73 0.00445 1509300.0 406.57 466.74 448.72 417.51 375.98 458.09 438.16 541.15 372.71 370.44 True False 416.0422899524942 412.0938638184608 387.7862886425275 344.599716133348 341.97267538466025 453.4820305124412 405.10923843536017 526.796944097069 632.461648338635 417.98958239116325 0.9953412895423629 0.9858950585826202 0.927741515528081 0.82442178142819 0.8181368383115233 1.0849122791966221 0.9691850120232197 1.2603111806841194 1.5131038546955085 1.0 8.707323176052425 -7.760197914232475 4.1338216318990515 1.2986830942733147 0.9376224339210489 0.5184935591366843 0.1377668077379302 0.14918849442502635 5.806630206003921 0.07445789278456848 0.036904539728031545 1.7370090683764695e-08 7.760197914232475 -0.3610606603522658 MYS(ph)FDDVLEEGK ddPTM_A459_Selumetinib_30min_R2 1 MYSFDDVLEEGK 12 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 MYS(1)FDDVLEEGK 136.99 0.0013614 3168900.0 4339.4 4349.8 5163.6 4270.0 3066.7 4781.0 3894.6 5311.2 5721.1 7316.7 True False 4098.233519994541 4683.415673188546 4831.3795977025975 3688.418633839143 2681.4337293541494 5439.539352403159 4075.706617003496 5326.654712683506 6865.479860890085 7105.447859930374 0.5767734280488689 0.6591302568835455 0.679954267900284 0.5190972767021733 0.3773771593590196 0.7655448973284649 0.5736030574494193 0.7496578425016691 0.9662276039778525 1.0 12.794709870785644 -8.114426291653508 1.9504536116968973 1.0081097762494025 0.5914032955701558 0.7156025961205312 0.0977425362431681 0.19013771778860838 1.2876220812331076 0.09059559271954036 0.028216689808309308 7.683758531633546e-09 8.114426291653508 -0.41670648067924665 NAASFPLRS(ph)PQPVCSPAGS(ph)EGTPK ddPTM_A459_Selumetinib_30min_R2 1 NAASFPLRSPQPVCSPAGSEGTPK 24 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 2 NAAS(0.098)FPLRS(0.901)PQPVCS(0.21)PAGS(0.634)EGT(0.157)PK 67.033 0.0047276 4030200.0 14927.0 14121.0 17539.0 19731.0 17642.0 12631.0 12238.0 14600.0 13166.0 17722.0 True False 14097.417097515448 15204.03529382856 16410.559835019325 17043.603762126502 15425.65423851891 14370.805597198136 12807.091249136945 14642.483582839877 15799.567888776426 17210.3198127142 0.8191258065466581 0.8834254946614364 0.9535302082472606 0.9903130184446349 0.8963025909096204 0.8350109558441582 0.7441518454337874 0.8507967162831384 0.9180287211806736 1.0 14.070986286220409 -6.604850899356077 5.819664126012676 0.8529598479895174 0.9161525488378393 0.042831946609921956 0.07445375671635726 0.4477913085985897 24.59045143452411 0.02558505197368999 0.025589896798452118 2.483985753261226e-07 6.604850899356077 0.06319270084832185 NAASFPLRS(ph)PQPVCSPAGSEGTPK ddPTM_A459_Selumetinib_30min_R2 4 NAASFPLRSPQPVCSPAGSEGTPK 24 1 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 NAAS(0.05)FPLRS(0.949)PQPVCS(0.001)PAGSEGTPK;NAAS(0.001)FPLRS(0.999)PQPVCSPAGSEGTPK;NAAS(0.016)FPLRS(0.894)PQPVCS(0.088)PAGS(0.001)EGTPK;NAAS(0.001)FPLRS(0.999)PQPVCSPAGSEGTPK 124.97 8.105e-08 45213800.0 92468.0 81842.0 92583.0 102238.0 97897.0 69188.1 76071.0 83909.0 59696.5 93625.0 True False 87328.99873873238 88119.01823649298 86626.3105767486 88313.00802961267 85598.30364971586 78718.13274796175 79608.45223182683 84153.16129811716 71637.4680595733 90921.80298303625 0.960484678851186 0.9691736783193113 0.9527561897657365 0.9713072676978225 0.9414496945874069 0.8657783959986869 0.8755705410580099 0.9255553512705643 0.7879019741055846 1.0 16.472338672689972 -6.620061623024869 4.706925304973269 0.8856282129137985 0.962406378593319 0.3201656616865173 0.04999579843409368 0.2320463712999062 8.822036169277354 0.015707263101482263 0.01569570386561912 2.398492567346176e-07 6.620061623024869 0.07677816567952056 NADSELMPPPPERGDPPRLS(ph)PDPVAGSAVSQELR ddPTM_A459_Selumetinib_30min_R1 3 NADSELMPPPPERGDPPRLSPDPVAGSAVSQELR 34 2 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 NADSELMPPPPERGDPPRLS(0.986)PDPVAGS(0.011)AVS(0.003)QELR;NADSELMPPPPERGDPPRLS(0.995)PDPVAGS(0.003)AVS(0.002)QELR;NADS(0.001)ELMPPPPERGDPPRLS(0.993)PDPVAGS(0.003)AVS(0.003)QELR 92.623 1.5994e-09 49517000.0 5406.4 5061.4 10166.2 11032.9 7798.6 6518.8 5997.7 5745.4 3686.85 4304.1 True False 5532.3586009768715 4468.808935018978 8785.685878939348 9106.21112818284 7093.2180069546575 6453.226790596828 5545.288660224024 5593.013328310632 6256.315173130034 4856.573160484303 1.1391486173813097 0.9201568240296711 1.8090298629544848 1.875028096410836 1.4605397206138893 1.3287613667809557 1.1418110006750195 1.1516378202264927 1.2882159840676932 1.0 12.245722979524286 -7.051138321245411 3.088974666901677 1.1586481439151168 1.454620722229333 0.20795286681487546 0.2702917273081465 0.4945315365475162 9.384427491299947 0.12335687476396694 0.09665702423060502 8.889179555649724e-08 7.051138321245411 0.2959725783142162 NADSELMPPPPERGDPPRLS(ph)PDPVAGSAVSQELR ddPTM_A459_Selumetinib_30min_R2 2 NADSELMPPPPERGDPPRLSPDPVAGSAVSQELR 34 2 E9PMR3;E9PMG4;Q9BUR4 E9PMR3 WRAP53 Telomerase Cajal body protein 1 1 NADSELMPPPPERGDPPRLS(0.968)PDPVAGS(0.016)AVS(0.016)QELR;NADSELMPPPPERGDPPRLS(0.926)PDPVAGS(0.062)AVS(0.012)QELR 67.083 0.0001322 4564700.0 8316.7 16153.2 14629.400000000001 15192.1 14954.599999999999 5551.2 5583.9 3943.09 3714.2000000000003 15196.400000000001 True False 7854.491108387936 17392.098499275657 13688.160331286384 13122.909772165724 13075.869452179724 6315.827411223674 5843.562414287942 3954.5637390863085 4457.143783418915 14757.640447011072 0.5322321773992494 1.178514855523408 0.9275304124961729 0.8892281811096409 0.8860406579988223 0.42797000197296753 0.3959686126837074 0.267967210157044 0.3020227928321454 1.0 13.849174451386917 -6.756667140429562 7.043449063231421 0.4267898409238295 0.903244677511283 0.4016568045872666 0.24179081682870604 0.1158759741713212 30.4675951687167 0.07837283985815068 0.07419624330002636 1.7511883508041506e-07 6.756667140429562 0.4764548365874535 NAEAVLQS(ph)PGLSGK ddPTM_A459_Selumetinib_30min_R1 4 NAEAVLQSPGLSGK 14 0 Q13045-2;Q13045-3;Q13045 Q13045-2 FLII Protein flightless-1 homolog 1 NAEAVLQS(0.993)PGLS(0.007)GK;NAEAVLQS(1)PGLSGK;NAEAVLQS(1)PGLSGK;NAEAVLQS(0.992)PGLS(0.008)GK 229.02 3.1474000000000003e-13 274160000.0 21726.6 27631.1 30592.5 31507.2 25014.7 24849.399999999998 24119.9 24259.2 13251.0 21993.0 True False 22232.78750739568 24396.03796665011 26438.206532573815 26005.058983393505 22752.12480170398 24599.437597449964 22300.516523957103 23615.767211012855 22485.979185251934 24816.015779961264 0.8959047940865865 0.9830763400122319 1.0653687024942358 1.0479143474913641 0.9168322990863078 0.9912726448745175 0.8986340402783187 0.9516341148558747 0.9061075470224831 1.0 14.598983888414582 -6.274284289275223 24.937197929033292 0.9417491369762893 1.0018026874829757 0.20116339259985228 0.05236936416855425 1163.5911541036144 2259000.3985170363 0.016728743275265336 0.019083454023566874 5.317600550484443e-07 6.274284289275223 0.06005355050668648 NAEAVLQS(ph)PGLSGK ddPTM_A459_Selumetinib_30min_R2 4 NAEAVLQSPGLSGK 14 0 Q13045-2;Q13045-3;Q13045 Q13045-2 FLII Protein flightless-1 homolog 1 NAEAVLQS(0.997)PGLS(0.003)GK;NAEAVLQS(1)PGLSGK;NAEAVLQS(1)PGLSGK;NAEAVLQS(1)PGLSGK 229.02 3.1474000000000003e-13 231268000.0 839580.0 726584.0 792850.0 879340.0 876940.0 650926.0 759560.0 761175.0 569135.0 777260.0 True False 792919.504705033 782310.6564642123 741838.8941898093 759572.3750538911 766770.9572569306 740585.1479820914 794881.0450395871 763389.8932306947 682977.9029605633 754818.4842359899 1.0504770633798246 1.0364222297179824 0.9828043558587225 1.006298058297702 1.0158348970919 0.9811433655227653 1.053075754820906 1.011355589686414 0.90482403017973 1.0 19.52577022698444 -8.130378083891728 8.539324991779061 0.9527690731080138 1.0165724429036278 0.4045093443160074 0.03148063872250995 0.2816046509004857 17.898921234486647 0.02063294704100748 0.007760088754959738 7.4066515943260716e-09 8.130378083891728 0.06380336979561396 NAEEES(ph)ESEAEEGD ddPTM_A459_Selumetinib_30min_R1 2 NAEEESESEAEEGD 14 0 H0Y503;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 H0Y503 BZW1 Basic leucine zipper and W2 domain-containing protein 1 1 NAEEES(1)ESEAEEGD;NAEEES(0.937)ES(0.063)EAEEGD 173.59 0.00010136 8626300.0 3942.2 3349.3599999999997 4929.4 5030.0 4144.4 3536.1000000000004 3788.1000000000004 3613.7 2073.25 3220.6 True False 4034.0455898141117 2957.215374124781 4260.014555256004 4151.604924793997 3769.539751753248 3500.5300445219145 3502.3605671831933 3517.8529370480974 3518.153825811152 3633.995381300564 1.1100855027422667 0.8137642082160349 1.17226746549452 1.142435388376357 1.0372989935953563 0.9632731132611171 0.9637768350519311 0.9680400132454486 0.9681228115793714 1.0 11.827340870613035 -6.696430093767826 5.154545314223054 0.9700555689310939 1.0543950719313684 0.1702940578759391 0.09150733547932517 0.40490754345193297 20.686312371795847 0.03189594026080937 0.03142059397122865 2.0117309905162622e-07 6.696430093767826 0.08433950300027448 NAEEES(ph)ESEAEEGD ddPTM_A459_Selumetinib_30min_R2 3 NAEEESESEAEEGD 14 0 H0Y503;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 H0Y503 BZW1 Basic leucine zipper and W2 domain-containing protein 1 1 NAEEES(0.803)ES(0.197)EAEEGD;NAEEES(1)ESEAEEGD;NAEEES(0.989)ES(0.011)EAEEGD 195.71 8.132199999999999e-05 31986000.0 47055.3 38796.9 49685.3 48153.8 52235.0 32097.8 36625.8 37504.9 35606.5 37251.6 True False 44440.154803290585 41772.497478304474 46488.601891264385 41595.16937006167 45672.77231317508 36518.98059518219 38328.97227264589 37614.03304972959 42728.79492873447 36176.0495167196 1.2284413416327158 1.154700362155308 1.2850657413485296 1.1497985525157328 1.2625140921500109 1.009479506000347 1.0595123786230796 1.0397496009713663 1.18113490830408 1.0 15.1427472514717 -6.7611194147228995 24.999999595067152 1.0605556908610916 1.2128402800789455 0.6308362747591001 0.06044091221859345 5.710332171600561 446182.2767295195 0.019622874268662254 0.01848127926153657 1.7333273321025414e-07 6.7611194147228995 0.15228458921785393 NAEQYKDQADK ddPTM_A459_Selumetinib_30min_R1 1 NAEQYKDQADK 11 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 106.16 0.031792 7129600.0 902.34 1234.1 1463.7 1641.6 1384.4 1657.2 1660.8 1640.2 1236.2 1119.9 False True 923.3627663520032 1089.6109982824753 1264.937579528587 1354.925376648474 1259.1812644356721 1640.5300726172095 1535.5245188822485 1596.6965678795375 2097.7411115242953 1263.6500737497668 0.7307108079470198 0.8622727295454141 1.0010188784106977 1.0722314704005484 0.9964635705667837 1.2982471229151957 1.2151501042735027 1.2635591142265243 1.66006488275622 1.0 10.303381296627732 -5.821876416308671 0.581494635768262 1.328804799944956 0.6849728254042942 0.563201288899785 0.16405532547518517 1.0131275018074875 0.5700970413841818 0.10492061112510037 0.3830549500245358 1.5070358502594955e-06 5.821876416308671 -0.6438319745406618 NAIEHPVR ddPTM_A459_Selumetinib_30min_R2 2 NAIEHPVR 8 0 Q99805 Q99805 TM9SF2 Transmembrane 9 superfamily member 2 0 ; 96.668 0.029354 1080720.0 15122.5 8192.3 9351.099999999999 11741.4 11346.2 7208.5 14850.8 12607.9 10289.6 10612.2 False True 14282.051990163962 8820.623067603688 8749.460406707862 10142.20106495525 9920.788919685026 8201.405442752175 15541.391626301936 12644.58690164979 12347.80751544539 10305.798212193076 1.3858268613552387 0.8558893630546506 0.8489842539664838 0.9841257179823034 0.9626414873859519 0.7958049705503514 1.508024056585397 1.2269391114886792 1.1981417898165672 1.0 13.331168629421766 -7.250290802796463 24.9962157284624 1.2521878431749698 0.9614299499437734 0.30698583596397166 0.19090657789838558 812.7772295628934 1822329.7162980156 0.07162061872979217 0.054973858623674134 5.6196490849816794e-08 7.250290802796463 -0.2907578932311964 NALFPEVFS(ph)PTPDENSDQNSR ddPTM_A459_Selumetinib_30min_R1 5 NALFPEVFSPTPDENSDQNSR 21 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 NALFPEVFS(1)PTPDENSDQNSR;NALFPEVFS(0.998)PT(0.002)PDENSDQNSR;NALFPEVFS(0.998)PT(0.002)PDENSDQNSR;NALFPEVFS(0.98)PT(0.019)PDENS(0.001)DQNSR;NALFPEVFS(0.988)PT(0.012)PDENSDQNSR 195.94 1.1001e-16 42114500.0 12927.39 15307.8 14160.719999999998 14479.399999999998 12647.990000000002 11822.5 13787.86 13804.130000000001 8118.570000000001 11586.250000000002 True False 13228.573034677851 13515.555659596856 12237.77200326709 11950.844602000427 11503.981537683996 11703.576383971127 12747.830619530236 13437.999630266422 13776.620333107754 13073.458047132108 1.0118648782125224 1.0338164249176391 0.9360776589596859 0.9141303363590212 0.879949397948892 0.8952165786418316 0.9750924792485716 1.0278840978278339 1.053785485327648 1.0 13.674353176963212 -7.645988214590198 3.7604635701854923 1.030998778223583 0.9438384744923562 0.38012241631173116 0.04659073461054946 0.2701555787955231 7.188909216013646 0.027956796426020204 0.014969254549471596 2.2594970851556406e-08 7.645988214590198 -0.08716030373122674 NALFPEVFS(ph)PTPDENSDQNSR ddPTM_A459_Selumetinib_30min_R2 2 NALFPEVFSPTPDENSDQNSR 21 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 NALFPEVFS(0.734)PT(0.265)PDENS(0.002)DQNSR;NALFPEVFS(0.911)PT(0.089)PDENSDQNSR 82.6 0.0056887 0.0 11268.4 8827.4 9903.5 11690.099999999999 10126.5 9606.5 10100.8 9330.3 9297.8 9668.0 True False 10642.147438979237 9504.433195435326 9266.319592115511 10097.88821345269 8854.318537941379 10929.708175875536 10570.50721435549 9357.449628285682 11157.619802238003 9388.859719519289 1.13348668069397 1.0123096392286872 0.9869483482484014 1.0755180623754919 0.9430664428326043 1.1641145466422134 1.1258563372056327 0.9966545361021524 1.1883892331505912 1.0 13.196734237334715 -6.77146772961726 24.999756563041444 1.0967221548995567 1.0293757454829842 0.1581514774784003 0.07461296703586778 381.91275575040635 952067.6480670156 0.02510399645971874 0.02238955047455118 1.6925140025286197e-07 6.77146772961726 -0.06734640941657255 NALPPVLTTVNGQS(ph)PPEHSAPAK ddPTM_A459_Selumetinib_30min_R1 2 NALPPVLTTVNGQSPPEHSAPAK 23 0 Q6PKG0;A0A0B4J210;H0YBM7 Q6PKG0 LARP1 La-related protein 1 1 NALPPVLTTVNGQS(1)PPEHSAPAK;NALPPVLTTVNGQS(1)PPEHSAPAK 170.1 1.443e-12 1242980000.0 14216.7 16458.2 17159.5 17632.4 14699.6 13150.6 14951.4 14193.0 8029.7 11980.5 True False 14547.921449117312 14531.266292790402 14829.334150386547 14553.232341140681 13370.02377542517 13018.316903789451 13823.603860558806 13816.555534638635 13625.814433915737 13518.31387495231 1.076163905032027 1.0749318611187866 1.0969810501192303 1.0765567714850846 0.9890304293198946 0.9630133627767522 1.0225834366941398 1.0220620457880423 1.0079522165232908 1.0 13.722627596558311 -6.2432735255472585 10.581086349656402 1.0010770787451655 1.0818809093493347 0.8432395340216348 0.016978009187515013 0.2361013564966202 135.18970212510632 0.00559517847190692 0.007087552936531435 5.71118823689739e-07 6.2432735255472585 0.08080383060416918 NALPPVLTTVNGQS(ph)PPEHSAPAK ddPTM_A459_Selumetinib_30min_R2 4 NALPPVLTTVNGQSPPEHSAPAK 23 0 Q6PKG0;A0A0B4J210;H0YBM7 Q6PKG0 LARP1 La-related protein 1 1 NALPPVLTTVNGQS(1)PPEHSAPAK;NALPPVLTTVNGQS(0.996)PPEHS(0.004)APAK;NALPPVLT(0.001)TVNGQS(0.866)PPEHS(0.133)APAK;NALPPVLTTVNGQS(1)PPEHSAPAK 121.91 6.9634e-06 636758000.0 379132.0 395322.0 377886.0 405790.0 405227.0 299749.0 325079.0 337490.0 253217.0 384833.0 True False 358061.3612256463 425641.9262394237 353573.22617116733 350520.70197320596 354318.7614846563 341036.7038994964 340195.8176318184 338472.0400255224 303867.47547412274 373721.8713737874 0.9580958157718368 1.1389269904776516 0.9460865238404313 0.9379186202956363 0.9480814172908693 0.9125414647150792 0.9102914324528867 0.9056789713198 0.8130845389302944 1.0 18.51160547165606 -5.448131686870049 6.952649197488399 0.9168982356957128 1.0485547623197187 0.4251779589542142 0.05971195568545059 0.21692959280791096 17.165542056357058 0.014999232426823847 0.03133730131525135 3.5634306661859984e-06 5.448131686870049 0.13165652662400584 NALTTLAGPLT(ph)PPVK ddPTM_A459_Selumetinib_30min_R2 1 NALTTLAGPLTPPVK 15 0 H0Y3X6;A0A0C4DFX9;Q9H3P2;C9JEM7;H7C2C7;C9JHL4;H7C0W2 H0Y3X6 NELFA Negative elongation factor A 1 NALTTLAGPLT(1)PPVK 100.58 0.017537 3269900.0 59922.0 65016.0 62530.0 62127.0 60122.0 51261.0 47487.0 50126.0 38951.0 55527.0 True False 56591.77512677167 70002.51814061022 58506.88787751632 53665.195424947175 52568.93686250052 58321.737448972664 49695.23959370536 50271.85836119397 46742.28838187228 53923.79123352793 1.0494769346185153 1.2981750084568442 1.0849921071784503 0.995204420856448 0.9748746454944175 1.081558549850446 0.9215828200671208 0.932276036443385 0.8668212548232245 1.0 15.71863431155752 -5.64468918115764 3.0082580112834343 0.9660653718663809 1.1776145510043028 0.5387160295077926 0.07748519609581118 0.18168966652669155 3.2713403369564347 0.02185920390747535 0.041872051908839567 2.266265663827973e-06 5.64468918115764 0.21154917913792193 NAMS(ph)LPQLNEK ddPTM_A459_Selumetinib_30min_R1 2 NAMSLPQLNEK 11 0 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 NAMS(1)LPQLNEK;NAMS(1)LPQLNEK 117.7 0.0055216 215710000.0 6576.8 7791.3 7464.1 7218.8 5398.5 6954.9 7142.6 5207.299999999999 3505.2 5369.5 True False 6730.0266437749115 6879.090973922898 6450.516217366487 5958.172093658627 4910.206628182586 6884.940020543953 6603.827931459746 5069.185488305765 5948.068390321112 6058.727628359116 1.1107986786323985 1.1354019186675273 1.064665159591186 0.9834031927380563 0.8104352810315086 1.1363673105748442 1.0899694352571943 0.8366749257019582 0.9817355648205671 1.0 12.564799134962374 -5.6103860300526875 3.1759436486655863 0.9744655743704029 1.1203510564570454 0.29281015864463145 0.09306329073336239 0.3239186744065035 6.498394471340414 0.027496719299254634 0.05332183257991064 2.452527975252017e-06 5.6103860300526875 0.14588548208664243 NAMS(ph)LPQLNEK ddPTM_A459_Selumetinib_30min_R2 7 NAMSLPQLNEK 11 0 Q9H3Q1;J3KRZ9 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 NAMS(1)LPQLNEK;NAMS(1)LPQLNEK;NAMS(1)LPQLNEK;NAMS(1)LPQLNEK;NAMS(1)LPQLNEK;NAMS(1)LPQLNEK;NAMS(1)LPQLNEK 123.63 0.0096648 157119300.0 478453.0 437831.0 453161.0 510408.0 459230.0 449336.0 418787.0 388151.0 310296.0 420197.0 True False 451862.4976591118 471411.22985144355 424005.11462439195 440889.549897088 401537.4218317101 511227.95533391 438261.42531069805 389280.455148143 372363.870394636 408064.8208070793 1.1073301951523498 1.1552361434124028 1.039063141453325 1.080439987512492 0.9840040144542251 1.2528106547454703 1.07399952890792 0.9539672015299329 0.9125115702406466 1.0 18.638438815920345 -7.7281278997953295 4.80905304846447 0.9483451715637267 1.1009431171770947 0.4756242467997933 0.06936024014511309 0.16382207009239189 8.908177472882493 0.035868906862197875 0.01902096287345587 1.8701313052866738e-08 7.7281278997953295 0.15259794561336804 NANGFSGAPAEPDLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 NANGFSGAPAEPDLSPR 17 0 Q6ZVF9 Q6ZVF9 GPRIN3 G protein-regulated inducer of neurite outgrowth 3 1 NANGFSGAPAEPDLS(1)PR;NANGFSGAPAEPDLS(1)PR 225.54 5.4442e-13 9899000.0 23084.0 16652.3 19079.0 23157.0 19185.2 13973.4 20479.2 19071.9 11741.4 16697.3 True False 21801.083692573633 17929.477864416218 17851.477911644557 20002.976651946854 16774.98365813586 15898.10901210421 21431.523378764963 19127.396071476982 14090.008082126653 16215.205564204542 1.3444839540424978 1.10572004736073 1.1009097504784107 1.23359377546862 1.034521800646613 0.9804444938520959 1.3216929809434899 1.1795962743575186 0.8689379870231609 1.0 13.9850596928639 -1.5228787452803376 0.1547349314459111 0.9941804780611296 1.8844436202683512 0.23829632606489826 0.1271413195785761 125.27794472838987 1.265664043629399 0.43304336231601853 25.205569821991634 0.029999999999999995 1.5228787452803376 0.8902631422072216 NAPAAVDEGSIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 NAPAAVDEGSISPR 14 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 NAPAAVDEGSIS(1)PR;NAPAAVDEGSIS(1)PR 274.6 7.9626e-45 217419000.0 3478.3 3439.2 4354.2 4143.3 3311.2 3179.6000000000004 3523.7 3522.7 1983.84 2959.6 True False 3559.3376224063786 3036.5368651592958 3762.9235559085696 3419.7504343735513 3011.7025446398397 3147.616110845812 3257.9044720528564 3429.2665526577553 3366.431586059179 3339.4934889452716 1.0658315802048597 0.9092806664277522 1.126794697568652 1.0240326701321487 0.9018441133691326 0.94254296984419 0.9755684455853861 1.0268822394802264 1.0080665218252651 1.0 11.705413586043793 -6.035544550843988 24.939627507666373 0.9743446891070944 1.0304857638382066 0.17153046876104305 0.0600334445768951 1082.8365058587035 759764.5271586481 0.01806981800861672 0.0233364920457207 9.214153631552786e-07 6.035544550843988 0.056141074731112184 NAPAAVDEGSIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 NAPAAVDEGSISPR 14 0 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 NAPAAVDEGSIS(1)PR;NAPAAVDEGSIS(1)PR;NAPAAVDEGSIS(1)PR;NAPAAVDEGS(0.001)IS(0.999)PR 238.83 1.9171e-19 219079600.0 579422.0 447408.0 537976.0 552037.0 564354.0 413432.0 441824.0 485466.0 429251.0 437980.0 True False 547220.044850044 481722.75495653716 503363.20986397995 476848.60828305787 493454.80513122637 470378.5052379712 462369.69145764736 486878.6256867776 515113.1942750393 425334.3793912981 1.2865643394102733 1.132574224651055 1.1834529119991428 1.1211146603420172 1.1601573468794513 1.1059028567385885 1.0870734035639231 1.1446961479661162 1.2110781992563706 1.0 18.698237945842436 -14.522874764350123 0.02089477961007338 3.181051945667569e-08 1.9353236713976292 0.4500860726451221 0.05384321687810302 3076.3679133019978 4.8463431103661545 306.79358624008836 163.03398546366213 3.0000274994177434e-15 14.522874764350123 1.9353236395871096 NAS(ph)ASFQELEDK ddPTM_A459_Selumetinib_30min_R1 1 NASASFQELEDK 12 0 F2Z3H0;F2Z3N9;H7C3L7;Q99543-2;Q99543 F2Z3H0 DNAJC2 DnaJ homolog subfamily C member 2;DnaJ homolog subfamily C member 2, N-terminally processed 1 NAS(0.913)AS(0.087)FQELEDK 214.89 1.1678e-06 11058000.0 2294.1 2938.9 1775.0 1626.5 2104.6 2133.9 2749.0 2801.4 1471.0 2994.8 True False 2347.5480664584625 2594.812221742458 1533.9647493770867 1342.4623081863683 1914.2393015973082 2112.434903426178 2541.6407167674042 2727.0977717703563 2496.179562410805 3379.211751822307 0.6947028593850327 0.7678749993524833 0.4539415881676742 0.39727084503136534 0.566475096023508 0.6251265261157445 0.7521401153380737 0.8070218654689854 0.7386869322600723 1.0 11.722471041713717 -8.064076501397423 0.7354018836585512 0.9674086086284989 0.5717353023288696 0.5668721637076373 0.11052910793536395 0.5236406258293232 0.5899408142755932 0.11804947728200907 0.05067142423098399 8.62826546640359e-09 8.064076501397423 -0.39567330629962927 NAS(ph)ASFQELEDKK ddPTM_A459_Selumetinib_30min_R1 1 NASASFQELEDKK 13 1 F2Z3H0;F2Z3N9;H7C3L7;Q99543-2;Q99543 F2Z3H0 DNAJC2 DnaJ homolog subfamily C member 2;DnaJ homolog subfamily C member 2, N-terminally processed 1 NAS(0.894)AS(0.106)FQELEDKK 176.42 0.00018168 6416900.0 1684.6 1735.5 1385.0 1122.7 1271.7 1533.0 1337.3 1358.0 958.19 1669.5 True False 1723.8479023390123 1532.3068531879383 1196.924607260431 926.6415206891089 1156.6749595368701 1517.5794118526326 1236.4263843335928 1321.9814285943262 1625.9784465713199 1883.7965873071146 0.9150923799067134 0.8134141783207971 0.6353789020137433 0.49190105074653634 0.614012663219831 0.8055962209922096 0.6563481390000091 0.7017644248332021 0.8631390764411855 1.0 10.879427475553985 -8.470448773602492 2.5115268052475472 0.9985092381245069 0.6963022709404468 0.41690497557048123 0.11300605626287455 0.2785010212996395 3.875285108661346 0.11850519105299061 0.032304122002908074 3.384941959647155e-09 8.470448773602492 -0.30220696718406004 NAS(ph)ASFQELEDKK ddPTM_A459_Selumetinib_30min_R2 1 NASASFQELEDKK 13 1 F2Z3H0;F2Z3N9;H7C3L7;Q99543-2;Q99543 F2Z3H0 DNAJC2 DnaJ homolog subfamily C member 2;DnaJ homolog subfamily C member 2, N-terminally processed 1 NAS(0.987)AS(0.013)FQELEDKK 101.53 0.0051536 32679000.0 69420.0 42946.0 50823.0 56191.0 50385.0 50177.0 72771.0 67522.0 43952.0 48772.0 True False 65561.91431027814 46239.8201068452 47553.1035118985 48537.68886511837 44055.18585238495 57088.42628854489 76154.99569300094 67718.47784113111 52743.62812148728 47363.82563512566 1.384219146809301 0.9762686921250957 1.0039962539814873 1.024783961478022 0.9301441608997274 1.2053170436090648 1.6078725624841284 1.4297510163729292 1.1135846273864307 1.0 15.531497993496057 -6.997289971712851 23.136681058225953 1.3354689287069605 1.0549372217796695 0.21472861264247678 0.19456560080039892 39.98549216422827 341361.98892642424 0.06798808453953926 0.059536922373654974 1.0062595805367094e-07 6.997289971712851 -0.280531706927291 NAS(ph)VPNLR ddPTM_A459_Selumetinib_30min_R1 1 NASVPNLR 8 0 E9PLD2;Q9H019-3;Q9H019;E9PPF9;E9PNJ0;E9PPQ0;E9PRW1;E9PSD6;C9JF50;E9PLU1;E9PRK5;Q9H019-2 E9PLD2 MTFR1L Mitochondrial fission regulator 1-like 1 NAS(1)VPNLR 94.363 0.022767 92910000.0 2784.4 3695.8 3814.7 3702.9 3406.6 3024.7 3061.7 3378.9 1992.8 2702.1 True False 2849.271102500737 3263.0940178691926 3296.6846926471944 3056.258027041686 3098.47363148408 2994.2742642078647 2830.753504011187 3289.280595785984 3381.6360516466734 3048.9408556828703 0.9345117656808685 1.0702385426031358 1.0812557044202935 1.002399905969044 1.0162458959178846 0.9820703011102647 0.928438312843948 1.0788272883861123 1.1091182845819059 1.0 11.574092449427388 NAS(ph)VPNLR ddPTM_A459_Selumetinib_30min_R2 4 NASVPNLR 8 0 E9PLD2;Q9H019-3;Q9H019;E9PPF9;E9PNJ0;E9PPQ0;E9PRW1;E9PSD6;C9JF50;E9PLU1;E9PRK5;Q9H019-2 E9PLD2 MTFR1L Mitochondrial fission regulator 1-like 1 NAS(1)VPNLR;NAS(1)VPNLR;NAS(1)VPNLR;NAS(1)VPNLR 97.597 0.020141 195802000.0 226091.0 185089.0 219329.0 231488.0 244100.0 173785.0 178948.0 183964.0 148782.0 181785.0 True False 213525.76733398336 199284.73114506298 205217.6109273593 199958.93506092645 213433.97571831226 197722.30628684003 187269.43657873513 184499.30478312017 178542.5573164162 176536.39471584762 1.2095283110186639 1.128859187737639 1.1624663076283894 1.132678252452021 1.2090083524241835 1.1200087472336409 1.060797898813802 1.045106336742005 1.0113640170560734 1.0 17.429606114382743 -7.340789891704814 1.6472193276280331 1.0169037762520798 1.1646699128177052 0.8523793815466366 0.027666565247897634 0.14170636046551097 0.747406848756602 0.01587397807799566 0.009032575323637982 4.5625759644455085e-08 7.340789891704814 0.14776613656562532 NASAS(ph)FQELEDK ddPTM_A459_Selumetinib_30min_R1 3 NASASFQELEDK 12 0 F2Z3H0;F2Z3N9;H7C3L7;Q99543-2;Q99543 F2Z3H0 DNAJC2 DnaJ homolog subfamily C member 2;DnaJ homolog subfamily C member 2, N-terminally processed 1 NAS(0.115)AS(0.885)FQELEDK;NAS(0.338)AS(0.662)FQELEDK;NAS(0.295)AS(0.705)FQELEDK 178.22 0.00010374 70616000.0 7117.299999999999 9924.099999999999 5918.0 5218.7 5931.0 5443.1 8096.799999999999 8342.400000000001 4389.49 9156.6 True False 7283.119242144984 8762.181758411078 5114.368105247099 4307.352012131698 5394.542097203095 5388.347355939377 7486.051857228923 8121.1324520657645 7448.643934334884 10331.93880283697 0.7049131224185307 0.8480675239777006 0.49500565216692755 0.41689677942623643 0.5221229238912882 0.5215233518862724 0.7245544132697905 0.7860221210210656 0.7209338030815297 1.0 13.334823382908448 -8.394837515687513 0.8407590981826039 0.9835806158500321 0.5886561200690417 0.4864208884698622 0.12398059505031414 0.5787655433827555 0.9105398056054607 0.133387785541538 0.04896158091844553 4.028677326314892e-09 8.394837515687513 -0.3949244957809904 NASAS(ph)FQELEDK ddPTM_A459_Selumetinib_30min_R2 5 NASASFQELEDK 12 0 F2Z3H0;F2Z3N9;H7C3L7;Q99543-2;Q99543 F2Z3H0 DNAJC2 DnaJ homolog subfamily C member 2;DnaJ homolog subfamily C member 2, N-terminally processed 1 NASAS(1)FQELEDK;NAS(0.04)AS(0.96)FQELEDK;NAS(0.087)AS(0.913)FQELEDK;NAS(0.179)AS(0.821)FQELEDK;NAS(0.045)AS(0.955)FQELEDK 214.89 1.1678e-06 116395600.0 200563.0 147975.0 161699.0 184105.0 153690.0 134439.0 223850.0 221817.0 171519.0 156930.0 True False 189416.51137730235 159324.20668538235 151295.4623845598 159029.58140116095 134382.08819396712 152956.75193426653 234259.4685503601 222462.45074621862 205827.59264127666 152399.02314689284 1.242898461328912 1.045441128135149 0.9927587412337325 1.0435078789703076 0.8817778842613726 1.003659661170112 1.537145473200077 1.4597367237176695 1.3505834118299145 1.0 17.217494129855645 -7.246520637364358 24.53932246181185 1.3751777936929048 1.0269825615464814 0.46461984011372925 0.156454511578698 480.49696668375316 790353.8838428466 0.05852520350765789 0.045134689430954784 5.6686463387963835e-08 7.246520637364358 -0.34819523214642345 NASAS(ph)FQELEDKK ddPTM_A459_Selumetinib_30min_R2 1 NASASFQELEDKK 13 1 F2Z3H0;F2Z3N9;H7C3L7;Q99543-2;Q99543 F2Z3H0 DNAJC2 DnaJ homolog subfamily C member 2;DnaJ homolog subfamily C member 2, N-terminally processed 1 NAS(0.052)AS(0.948)FQELEDKK 156.72 0.00065571 4240100.0 35626.0 20055.0 18034.0 25772.0 29036.0 19429.0 33221.0 40503.0 23899.0 23759.0 True False 33646.04954217765 21593.154013011237 16873.71207393459 22261.809140820245 25388.238094866505 22105.168391098287 34765.842326162674 40620.85702436742 28679.467793852957 23073.015936704476 1.458242374316295 0.9358617907709638 0.7313180088907208 0.9648417528896269 1.1003432825822732 0.9580528376411104 1.5067749453099146 1.7605352128998402 1.242987387194136 1.0 14.493918974491205 -7.260172381125071 24.985309776360193 1.4409523334021719 1.0081065804328138 0.30594411758600015 0.2524744007238877 116.4432803104416 2296303.3818738945 0.09961160990276251 0.07283569316430429 5.493227921636882e-08 7.260172381125071 -0.4328457529693581 NASVYS(ph)PSGPVNR ddPTM_A459_Selumetinib_30min_R1 1 NASVYSPSGPVNR 13 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 NAS(0.06)VYS(0.907)PS(0.033)GPVNR 165.89 0.00034641 10949000.0 1862.2 2436.6 2237.7 2483.4 2324.3 1838.3 2329.6 1920.4 1046.3 1985.9 True False 1905.58563678957 2151.321739255392 1933.8326308062585 2049.720809191534 2114.0674753884946 1819.808371042854 2153.8763964282807 1869.4647536616674 1775.4946812715343 2240.8096093041017 0.8504005109927042 0.9600644920134466 0.8630062200629455 0.9147233217319558 0.9434391331644781 0.8121209242796882 0.9612045519106737 0.8342809428786063 0.7923451746634226 1.0 11.12980435993547 -6.722114662893575 24.999842454934676 0.8747083209012896 0.9073718975190291 0.034210006672283244 0.06697784823446695 532.8449835006755 338742.9273775574 0.0211583710422653 0.02115804827730992 1.8962052169865076e-07 6.722114662893575 0.032663576617739554 NASVYS(ph)PSGPVNRR ddPTM_A459_Selumetinib_30min_R1 2 NASVYSPSGPVNRR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 NASVYS(0.768)PS(0.232)GPVNRR;NAS(0.003)VYS(0.783)PS(0.213)GPVNRR 132.51 0.0014405999999999998 9011800.0 2085.32 1972.89 3260.3999999999996 3900.9 2850.3 2668.5 2160.5 1963.4899999999998 1360.15 1717.0700000000002 True False 2133.9038986736246 1741.9031216283222 2817.6555880952415 3219.681043962007 2592.4908682613377 2641.657312804142 1997.53174557147 1911.411866885621 2308.0752085744803 1937.4726601781524 1.1013852956652355 0.899059458969683 1.4542943732873914 1.6617943107728572 1.33807868443571 1.363455271963032 1.0309986750408107 0.9865490781737611 1.191281433804723 1.0 10.9199602372148 -7.266083478877768 24.71340455865129 1.0510863695859833 1.3094285943197432 0.2800756259605184 0.19682614300548168 518.2046870247224 2757587.547053658 0.09076860428886384 0.06344221289943701 5.4189671850962567e-08 7.266083478877768 0.2583422247337599 NASVYSPS(ph)GPVNR ddPTM_A459_Selumetinib_30min_R2 1 NASVYSPSGPVNR 13 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 NAS(0.204)VYS(0.151)PS(0.645)GPVNR 165.49 0.00035684 3551400.0 15936.0 14751.0 16038.0 17811.0 17929.0 13323.0 17475.0 17528.0 12611.0 17890.0 True False 15050.340916862486 15882.35426805927 15006.132540854102 15385.111074311231 15676.598732706345 15158.122315847573 18287.622126055583 17579.003578083386 15133.552380780773 17373.469216197776 0.8662829933143478 0.9141728730409067 0.8637384021645752 0.8855520381598431 0.9023297844330715 0.8724867858697575 1.0526177528783667 1.0118303580780506 0.8710725642908058 1.0 14.084598246508403 -7.239791990266713 24.880611506780266 0.9848660360188215 0.8854309807144927 0.5367585985361958 0.04540023242190294 594.2827145630647 683044.6436269269 0.017250749702216545 0.013350741437951464 5.757156161277562e-08 7.239791990266713 -0.09943505530432883 NATDLQNS(ph)SMSEEELTK ddPTM_A459_Selumetinib_30min_R1 1 NATDLQNSSMSEEELTK 17 0 Q5QNY5;H0YJ60;P40855-5;P40855 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 NATDLQNS(0.751)S(0.228)MS(0.021)EEELTK 265.43 5.852199999999999e-41 17740000.0 3324.5 3769.1 3989.5 4418.3 3482.8 3341.6 3315.8 3761.6 2303.9 3403.8 True False 3401.9543816490805 3327.812019792949 3447.7478127548666 3646.726846762884 3167.78135493828 3307.9865379300422 3065.686536434106 3661.8301486011887 3909.5500298016723 3840.71088581968 0.8857616422546837 0.8664573092652172 0.8976848076444193 0.9494926734076742 0.8247903706144796 0.861295378973587 0.7982080993789333 0.9534250969322012 1.0179235422890471 1.0 11.90715765199558 -7.968100896923305 6.758048429491331 1.0018847642173816 0.8711683078904685 0.6874578032834819 0.03863393005068519 0.10172289699653182 14.733026939430529 0.023038779207908446 0.01071248675792028 1.0762151542415037e-08 7.968100896923305 -0.1307164563269131 NATDLQNSS(ph)MSEEELTK ddPTM_A459_Selumetinib_30min_R1 3 NATDLQNSSMSEEELTK 17 0 Q5QNY5;H0YJ60;P40855-5;P40855 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 NATDLQNS(0.021)S(0.779)MS(0.2)EEELTK;NATDLQNS(0.062)S(0.726)MS(0.212)EEELTK;NATDLQNS(0.293)S(0.615)MS(0.091)EEELTK 281.65 8.409499999999997e-64 48613800.0 8367.7 9817.2 10219.9 10861.4 8751.2 8298.0 10107.8 8257.400000000001 5086.46 7896.799999999999 True False 8562.651129290132 8667.797660107544 8832.093713892336 8964.660383729124 7959.655505149849 8214.52965398118 9345.360508163534 8038.386928184672 8631.351119660147 8910.431201345795 0.9609693331111591 0.972769719471982 0.9912083393403422 1.0060860334542663 0.8932963316015117 0.9219003512131368 1.0488112524511777 0.9021322028692155 0.9686793966106267 1.0 13.121279534253341 NATDLQNSS(ph)MSEEELTK ddPTM_A459_Selumetinib_30min_R2 4 NATDLQNSSMSEEELTK 17 0 Q5QNY5;H0YJ60;P40855-5;P40855 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 NATDLQNS(0.005)S(0.892)MS(0.103)EEELTK;NATDLQNS(0.006)S(0.97)MS(0.024)EEELTK;NATDLQNS(0.287)S(0.472)MS(0.241)EEELTK;NATDLQNS(0.119)S(0.763)MS(0.119)EEELTK 340.8 1.0896999999999992e-154 55292100.0 219312.0 206134.0 207459.0 247862.0 237383.0 190695.0 206688.0 198203.0 149937.0 225212.0 True False 207123.51701549598 221943.81497472266 194111.31380428022 214102.76801420053 207560.82530905414 216961.50529314388 216299.40154450244 198779.7379157268 179928.58958981282 218709.54438895086 0.9470255063361551 1.014787971850099 0.8875301457309728 0.9789365553861806 0.949024999750034 0.9920074859984241 0.9889801661322917 0.9088754606987745 0.8226828421800817 1.0 17.73865665477779 -7.860089032333754 6.309161489411148 0.8971226298920971 0.965135086474711 0.18086534214086825 0.05169294945208836 0.28928739231272743 15.591485543306085 0.02714426974530727 0.012890977117755201 1.380101308587721e-08 7.860089032333754 0.0680124565826139 NATDLQNSSMS(ph)EEELTK ddPTM_A459_Selumetinib_30min_R2 2 NATDLQNSSMSEEELTK 17 0 Q5QNY5;H0YJ60;P40855-5;P40855 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 NATDLQNS(0.275)S(0.078)MS(0.647)EEELTK;NATDLQNS(0.017)S(0.19)MS(0.792)EEELTK 225.86 2.0173e-13 50949100.0 231474.0 195997.0 217287.0 253750.0 236128.0 195993.0 214144.0 216105.0 163717.0 223276.0 True False 218609.60174383956 211029.33967031504 203306.99098419753 219188.81225683462 206463.48962889644 222989.25670268826 224102.12031828603 216733.82977189156 196464.97463518195 216829.44173928286 1.0082099552084682 0.9732503943078823 0.9376355413424676 1.0108812276535244 0.9521930600049668 1.0284085727196217 1.0335410104857803 0.9995590452725223 0.9060807105310574 1.0 17.72620113780483 -5.807982965669925 24.99910554100254 0.9919038293286143 0.9730529270202846 0.03779047220827636 0.03870859631677072 441.0586430009349 236896.0456553252 0.011217359393093037 0.01663809008232436 1.5560266624333816e-06 5.807982965669925 -0.018850902308329753 NATS(ph)PQVQR ddPTM_A459_Selumetinib_30min_R2 1 NATSPQVQR 9 0 A0A087WZ06;Q13188;Q13188-2 A0A087WZ06 STK3 Serine/threonine-protein kinase 3;Serine/threonine-protein kinase 3 36kDa subunit;Serine/threonine-protein kinase 3 20kDa subunit 1 NAT(0.21)S(0.79)PQVQR 107.09 0.012789 4949500.0 23817.0 17253.0 19770.0 21055.0 23804.0 19789.0 24087.0 31048.0 23772.0 21968.0 True False 22493.346487005136 18576.249622861284 18498.019723948477 18187.272678099118 20813.52870953996 22514.755123343657 25207.093227485035 31138.34453972692 28527.06424517645 21333.72676028132 1.0543561722597279 0.8707456428778375 0.8670786839919455 0.8525126848422845 0.975616166055438 1.0553596835814525 1.1815607048279566 1.4595829828335305 1.3371814763413739 1.0 14.380848389716233 -7.133340899070497 1.8436526665998583 1.2974344524232957 0.9114485204853684 0.5981312804869293 0.12322461619716688 0.21451688784912012 1.4374147862973197 0.059253243374927676 0.04100969857841353 7.35629439128808e-08 7.133340899070497 -0.3859859319379273 NAVALSAS(ph)PQLK ddPTM_A459_Selumetinib_30min_R2 2 NAVALSASPQLK 12 0 Q92547;A0A2R8YD63 Q92547 TOPBP1 DNA topoisomerase 2-binding protein 1 1 NAVALS(0.433)AS(0.567)PQLK;NAVALS(0.464)AS(0.536)PQLK 117.0 0.004875 15081000.0 118620.0 117394.0 114014.0 127866.0 119686.0 101240.0 110841.0 99271.0 78357.0 118804.0 True False 112027.57527348305 126397.74231879525 106678.46336905715 110450.43021884665 104649.97467358419 115184.8910347827 115995.32612727469 99559.86217480125 94030.58947750703 115373.8198301378 0.97099650023219 1.0955496013297272 0.9246331925745146 0.9573266307855652 0.9070513122271406 0.998362463896634 1.0053868919140574 0.8629328761185243 0.8150080288227094 1.0 16.815956364917476 -5.376332910011666 0.5255946612123372 0.9157207942295897 1.0623037387290528 0.17634280346315234 0.06896150681154231 4.159948650273726 1.3675194742617347 0.047714498269893366 0.34887613448469296 4.204042424389915e-06 5.376332910011666 0.14658294449946307 NAVEEYVYEFR ddPTM_A459_Selumetinib_30min_R2 1 NAVEEYVYEFR 11 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 133.05 0.026243 3151800.0 21182.0 18786.0 17129.0 21818.0 17253.0 15647.0 16854.0 17525.0 11963.0 18941.0 False True 20004.789238264373 20226.825793489366 16026.93878864509 18846.35076185069 15085.523896223036 17802.23222067606 17637.74439556744 17575.994848580078 14355.934274147994 18394.124115371847 1.087564110842685 1.0996351697217235 0.8713075266928031 1.024585386270223 0.8201273298800982 0.9678216863720546 0.9588792749760612 0.9555222492976404 0.780463053532994 1.0 14.166957359774738 -5.2515377927019395 24.5421512311414 0.9236805518782281 1.093599676607631 0.4637067076987924 0.07366005920119621 444.23380451601867 1101073.7372203267 0.017806328401557294 0.04585045000165805 5.60353652756478e-06 5.2515377927019395 0.16991912472940296 NAWGS(ph)IER ddPTM_A459_Selumetinib_30min_R2 1 NAWGSIER 8 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 NAWGS(1)IER 86.014 0.034466000000000004 3933500.0 12996.0 9589.9 12246.0 13572.0 15221.0 10944.0 12430.0 11496.0 10709.0 11043.0 True False 12273.734347109983 10325.41449361139 11458.105692436666 11723.470186994107 13308.801902533523 12451.436660259385 13008.019629577739 11529.451456734745 12851.099234460484 10724.159896840254 1.144493784611165 0.9628180289118637 1.0684385352938144 1.093183083781536 1.2410111403183015 1.1610640628295792 1.2129639761721938 1.075091342132241 1.1983315577238742 1.0 13.38857701467435 -6.018910804079543 5.882409547146094 1.1569131264764294 1.0532511817889112 0.21027413657878147 0.07748590434950313 0.21740905816596484 26.867323832554547 0.021496021139484525 0.029531051357536343 9.573906811480685e-07 6.018910804079543 -0.10366194468751821 NCDLDVACR ddPTM_A459_Selumetinib_30min_R2 1 NCDLDVACR 9 0 P30838;A8MYB8;C9JMC5;I3L3I9;E9PNN6;C9JKT2 P30838 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 0 133.99 0.041407 16274000.0 148790.0 117440.0 127060.0 124780.0 145430.0 98465.0 94627.0 113330.0 102440.0 112690.0 False True 140520.84745356246 126447.27037088222 118885.09793246786 107784.74874249387 127159.78323930425 112027.65997372447 99027.34299984337 113659.77153720864 122930.86241274909 109436.3468962176 1.2840418328914378 1.1554412583855407 1.0863401539272035 0.9849081388353543 1.1619520099651575 1.0236787242173233 0.9048853128636918 1.0385925221443681 1.1233092651505339 1.0 16.73973245185409 -3.8881132290628955 0.773564676433845 1.0282305080510141 2.089332586419385 0.5736367921137331 0.06748478946138146 6.813773750097345 1.1243773919002091 0.0262077436254665 8.633209834093313 0.00012938584632720478 3.8881132290628955 1.0611020783683707 NCES(ph)DTEEDIAR ddPTM_A459_Selumetinib_30min_R1 2 NCESDTEEDIAR 12 0 Q9UIK4 Q9UIK4 DAPK2 Death-associated protein kinase 2 1 NCES(0.971)DT(0.029)EEDIAR;NCES(0.92)DT(0.08)EEDIAR 241.3 2.0315e-13 12211500.0 1611.51 1928.79 1797.35 1904.28 1701.91 1420.01 1766.77 1657.98 992.56 1492.96 True False 1649.0550475473945 1702.9663701298557 1553.2797421368487 1571.7332457627647 1547.972540996616 1405.7259886659212 1633.501116465312 1614.004984521958 1684.3018262858395 1684.5959586618924 0.9789024122183406 1.0109049362094844 0.9220488355977354 0.9330030964880286 0.9188984058979941 0.8344588394848798 0.9696693786222982 0.9580961988084038 0.9998253988592692 1.0 10.718186894862722 -8.010306320821668 2.052263210256494 0.9998872255376141 0.9351777911713812 0.23855380185438124 0.04389178470111998 0.5507134896094665 4.234958225598862 0.04050532163594367 0.013511803073227871 9.765481894893554e-09 8.010306320821668 -0.06470943436623289 NCES(ph)DTEEDIAR ddPTM_A459_Selumetinib_30min_R2 2 NCESDTEEDIAR 12 0 Q9UIK4 Q9UIK4 DAPK2 Death-associated protein kinase 2 1 NCES(1)DTEEDIAR;NCES(0.995)DT(0.005)EEDIAR 146.27 0.00066081 18098700.0 27048.0 26541.0 30853.0 33687.0 34856.0 24920.0 24012.0 23572.0 19898.1 28751.0 True False 25544.780441722916 28576.609357234167 28867.951570206485 29098.772486683676 30477.07766340636 28352.50379876315 25128.60557887534 23640.590617445327 23878.275999366728 27920.883925930826 0.9148987012548997 1.023485124362211 1.0339196870266738 1.042186650103112 1.0915513185132915 1.015458675089848 0.8999931966887973 0.8466992191278628 0.85521203636359 1.0 14.769056994999982 -7.268308521452724 4.668825533073168 0.8860426364890943 1.0259725918930067 0.5087006366171766 0.05701268585540482 0.14534716480014503 8.92443442781729 0.023819519508511765 0.01676124428816613 5.391274919459995e-08 7.268308521452724 0.1399299554039124 NCGEIFCNACSDNELPLPS(ph)SPKPVR ddPTM_A459_Selumetinib_30min_R2 1 NCGEIFCNACSDNELPLPSSPKPVR 25 1 H0YD93;Q8WXA3;Q8WXA3-3;Q8WXA3-1 H0YD93 RUFY2 RUN and FYVE domain-containing protein 2 1 NCGEIFCNACS(0.003)DNELPLPS(0.499)S(0.499)PKPVR 70.461 0.00062182 3246000.0 14702.0 12878.0 11119.0 12533.0 11389.0 8792.4 12488.0 12168.0 9489.5 10658.0 True False 13884.921696769094 13865.70119070351 10403.615645451851 10825.983779369088 9958.212001048167 10003.473290539529 13068.71674450255 12203.406865479166 11387.665158783522 10350.27584719039 1.3415025745944917 1.3396455703610441 1.0051534663470771 1.0459608941058154 0.962120444717553 0.9664933996184263 1.2626442944561798 1.1790417033949692 1.1002281800899765 1.0 13.337381597329168 -5.252523549749555 24.527598016490632 1.0707567098303599 1.3405741338849009 0.5961717983378794 0.09056190738139161 377.71775467655795 1039100.2534158863 0.02581379316367001 0.06606383720989496 5.5908321029251375e-06 5.252523549749555 0.269817424054541 NCGS(ph)PGSSQLSSNSLYAK ddPTM_A459_Selumetinib_30min_R2 1 NCGSPGSSQLSSNSLYAK 18 0 U3KQE5;H7C4S2;O60381-2;O60381-3;O60381 U3KQE5 HBP1 HMG box-containing protein 1 1 NCGS(0.768)PGS(0.222)S(0.01)QLSSNSLYAK 146.18 0.00011044 0.0 6106.9 5589.3 6811.9 6864.8 6274.6 4494.0 5079.3 6238.2 4420.6 5879.6 True False 5767.502945857648 6017.981337567879 6373.629770235938 5929.802397559472 5486.328652364289 5113.007707529763 5315.497514442008 6256.352129210398 5304.843521884023 5709.840670964587 1.0100987537509203 1.0539665963308282 1.1162535239637807 1.0385232687338237 0.9608549464896822 0.8954729216053592 0.9309362241002845 1.095713959414823 0.9290703239514132 1.0 12.479234773434738 -6.167937067846611 4.464847014490723 0.9680045400499456 1.0616187784475857 0.3642033824403066 0.0560080390109508 0.2606260564018259 8.981631237720144 0.01767414620302875 0.02309056684434141 6.79302060863564e-07 6.167937067846611 0.09361423839764005 NCIVLIDSTPYR ddPTM_A459_Selumetinib_30min_R2 2 NCIVLIDSTPYR 12 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 ; 155.33 0.0058868 10651200.0 48043.0 38931.0 52100.0 45943.0 52718.0 32924.0 45723.0 48636.0 40129.0 43657.0 False True 45372.96239136699 41916.88251710501 48747.94272219095 39685.48414390441 46095.09353510031 37458.982145685295 47849.210098405674 48777.52270787678 48155.92129794237 42396.508975491684 1.070205153391189 0.9886871237755936 1.1498103004275861 0.9360554702002836 1.087237950694164 0.8835393066759188 1.1286120309119332 1.1505079990447749 1.1358463812617225 1.0 15.371657854453542 NCPAVTLT(ph)SPAK ddPTM_A459_Selumetinib_30min_R1 1 NCPAVTLTSPAK 12 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 NCPAVT(0.003)LT(0.498)S(0.498)PAK 167.73 0.00097631 26704000.0 4152.7 4509.6 5714.0 5770.0 4639.7 4096.4 4468.2 4145.0 3028.6 4100.7 True False 4249.449830252414 3981.6139355438368 4938.070184755306 4762.377816314387 4220.039954205566 4055.1939352336117 4131.1600766315405 4035.0611351424723 5139.312999807867 4627.064789200528 0.9183899564515589 0.8605053347938503 1.0672144025907435 1.0292438150919514 0.9120339019360719 0.8764074245725604 0.892825206656622 0.8720563292219767 1.1107069457516383 1.0 12.175881584646753 -8.262387761660015 24.999982808543887 1.0553534745329438 0.9308086398196129 0.3497665725159744 0.06908500172371908 105.55936961785986 2782403.7313336353 0.059678734938423614 0.018877861242187315 5.465277753567783e-09 8.262387761660015 -0.12454483471333089 NCPAVTLT(ph)SPAK ddPTM_A459_Selumetinib_30min_R2 1 NCPAVTLTSPAK 12 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 NCPAVT(0.001)LT(0.913)S(0.086)PAK 174.46 0.0003318 59736000.0 442970.0 384470.0 398860.0 398140.0 399390.0 330810.0 396830.0 379770.0 279980.0 434410.0 True False 418351.50074940844 413957.6127341023 373197.7818459323 343912.64517019084 349215.0576080977 376376.0747058123 415283.38130372757 380875.0678256918 335983.82329482166 421867.4545672719 0.9916657381843548 0.981250409939105 0.8846327864488569 0.8152149246093354 0.827783830744429 0.8921666524190113 0.9843930286817267 0.9028311231459467 0.7964203440141053 1.0 18.68643026797777 -5.252592872418174 5.8967600270419895 0.8831399993731157 0.987712500599011 0.2796890511669412 0.06293142253882554 0.1948891594711829 28.903736733705998 0.016839944921760268 0.041638276219859306 5.589939758014864e-06 5.252592872418174 0.10457250122589523 NCPAVTLTS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 NCPAVTLTSPAK 12 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 NCPAVTLT(0.003)S(0.997)PAK 148.13 0.00061112 21007000.0 5392.5 6289.7 7342.6 7574.5 5500.4 6118.4 6530.0 5357.2 3703.7 5987.5 True False 5518.1347580215615 5553.298999997797 6345.515250014759 6251.75576597458 5002.889791174495 6056.854451062718 6037.43684266684 5215.109653361942 6284.908392454724 6756.053948188885 0.8167689009500618 0.8219737501484111 0.9392339520491572 0.9253561048976682 0.7405047131862578 0.8965077096056043 0.8936336046110633 0.7719165201100816 0.9302632040319242 1.0 12.721965133001774 -8.521285852069855 23.37128701145577 1.0000000036050443 0.8542835970206775 0.38114837268172563 0.06146577207542892 56.33544846459624 826552.0841454134 0.05955201765937092 0.015376264839358108 3.01102352000559e-09 8.521285852069855 -0.1457164065843668 NCPAVTLTS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 NCPAVTLTSPAK 12 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 NCPAVTLT(0.027)S(0.973)PAK 179.83 0.00010392 55239000.0 455070.0 420590.0 387790.0 449950.0 485000.0 323370.0 405830.0 441010.0 323790.0 443180.0 True False 429779.031189546 452847.90058999823 362840.0135938271 388666.03379295644 424069.96404498763 367911.2822394077 424701.89913688897 442293.2660868642 388557.04744849744 430384.24188007455 0.9985937898472194 1.052194426570532 0.8430606381144677 0.9030675289018998 0.985328742968135 0.8548437569002009 0.9867970474049815 1.027670679007128 0.9028142985698995 1.0 18.71526573035723 NCPHIVVGT(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 NCPHIVVGTPGR 12 0 Q13838;Q13838-2;F6S4E6;A0A0A0MT12;F6TRA5;F6WLT2;A0A0G2JJZ9;Q5STU3;A0A140T9L4;A0A140T973;A0A140T9K1;A0A140T9X9;A0A140T996;F6UJC5;A0A140TA18;A0A140T9X3 Q13838 DDX39B Spliceosome RNA helicase DDX39B 1 NCPHIVVGT(1)PGR 100.11 0.032144 7409100.0 1539.4 1738.6 1991.7 2001.5 1840.6 1495.2 1658.2 1481.5 876.88 1519.9 True False 1575.2650248490297 1535.0439037467875 1721.238079624982 1651.975597808188 1674.118054984323 1480.1596455329777 1533.1206389755212 1442.2058074097886 1488.0013152187553 1714.9939700797142 0.9185251099021707 0.8950724786953259 1.0036408930026604 0.9632544642308001 0.9761655633730938 0.863069883251064 0.89395103756794 0.8409392875840571 0.8676423014767753 1.0 10.743987788552078 -6.763587034065767 24.988667675770298 0.8832311118741946 0.9517746334354179 0.2501461734989463 0.048913657876154294 69.76786732459638 811765.7105168492 0.01660891337026809 0.015363884499099612 1.7235066599200145e-07 6.763587034065767 0.06854352156122334 NCPHVVVGT(ph)PGR ddPTM_A459_Selumetinib_30min_R1 2 NCPHVVVGTPGR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 NCPHVVVGT(1)PGR;NCPHVVVGT(1)PGR 115.83 0.01207 13446400.0 3359.2 4033.3 3974.5 4317.4 3331.7 3489.8 3729.8 3808.3 2371.2 3182.8999999999996 True False 3437.4628241346372 3561.079360969701 3434.7847303657622 3563.4471376353076 3030.3483232594085 3454.6957804848767 3448.4581831207943 3707.291512898212 4023.7532144041515 3591.4562190714637 0.9571222964882362 0.9915419105095993 0.9563766118395821 0.9922011909020577 0.8437659095404136 0.96192061652865 0.9601838287234808 1.0322530157019976 1.1203681651573785 1.0 11.81035321340565 -7.826374744539707 3.4233855222425 1.0646235589407371 0.950542700664708 0.48349932154361497 0.04737384256829218 0.1962542608642196 4.563034609355706 0.028794070665520352 0.012928433449836173 1.491506860941864e-08 7.826374744539707 -0.1140808582760291 NCPPS(ph)PLPLISK ddPTM_A459_Selumetinib_30min_R1 1 NCPPSPLPLISK 12 0 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 NCPPS(0.996)PLPLIS(0.004)K 102.63 0.011437 19275000.0 3467.8 4168.0 4683.1 4764.2 3604.5 3995.6 4264.5 4337.7 3252.8 3593.5 True False 3548.592992835823 3680.008622349367 4047.16074242695 3932.2219051100487 3278.4736114261627 3955.407891714532 3942.8253316313517 4222.65010516466 5519.764024887743 4054.760728654155 0.8751670518456615 0.9075772576032681 0.998125663451977 0.9697790247700314 0.8085492167904922 0.9754972380398387 0.9723940808068453 1.0414054953536631 1.3613044996417947 1.0 11.98540106821219 -7.9473463703906875 3.344952787931879 1.187571273292398 0.9298294205363976 0.5069279558409926 0.09792974444279937 0.17692597242987496 3.96417740896017 0.0623741087361195 0.025083151825447535 1.1288952082192178e-08 7.9473463703906875 -0.25774185275600037 NCPPS(ph)PLPLISK ddPTM_A459_Selumetinib_30min_R2 4 NCPPSPLPLISK 12 0 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 NCPPS(0.998)PLPLIS(0.002)K;NCPPS(0.994)PLPLIS(0.006)K;NCPPS(0.988)PLPLIS(0.012)K;NCPPS(1)PLPLISK 113.25 0.0062942 29612000.0 168738.0 159239.0 140516.19999999998 175431.8 173765.0 114666.2 146456.5 137924.80000000002 115693.6 158057.1 True False 159360.21747173346 171452.11926591332 131475.5406744706 151537.6862032648 151935.08722119036 130460.42821387367 153267.01744804933 138326.13833332015 138835.55274927424 153493.58084133602 1.0382207294809396 1.1169986283865563 0.856554000198711 0.9872574825126206 0.9898465224955781 0.8499406131434815 0.9985239552556866 0.9011851673217903 0.9045039667996698 1.0 17.227818797250407 -5.251547860720373 24.98878850982295 0.9353638872475568 1.0776096883834634 0.4963881812336992 0.05706134056922586 524.9727763375427 1326223.998165071 0.01384113626722397 0.03570287650019585 5.603406625257776e-06 5.251547860720373 0.14224580113590657 NCPS(ph)PVLIDCPHPNCNK ddPTM_A459_Selumetinib_30min_R1 2 NCPSPVLIDCPHPNCNK 17 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 NCPS(1)PVLIDCPHPNCNK;NCPS(1)PVLIDCPHPNCNK 122.19 0.00092498 46632000.0 6376.9 8069.6 6171.6 7514.200000000001 6537.2 5900.0 7059.1 6132.2 3732.8999999999996 6542.3 True False 6525.469362712602 7124.807480544734 5333.530618172183 6201.986029003391 5945.911414236402 5840.651356771385 6526.626403685982 5969.55413580716 6334.4586597711095 7382.067932398524 0.8839622477698328 0.9651506252435416 0.7224981762582146 0.8401420964692058 0.8054533592329735 0.7911944742661946 0.8841189844707107 0.8086560826144522 0.8580872890603387 1.0 12.849809298496425 -8.57020228882721 17.4253838923113 1.000000002400395 0.83683837957857 0.382232274811946 0.06153646970961629 411.68634488375596 151591.72420110097 0.06004598882769133 0.01550380168421902 2.6902814132939244e-09 8.57020228882721 -0.163161622821825 NCPS(ph)PVLIDCPHPNCNK ddPTM_A459_Selumetinib_30min_R2 2 NCPSPVLIDCPHPNCNK 17 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 NCPS(1)PVLIDCPHPNCNK;NCPS(1)PVLIDCPHPNCNK 214.34 9.9316e-10 14659000.0 103625.0 80096.0 96444.0 101961.0 107993.0 89437.0 101393.0 97554.0 84875.0 86381.0 True False 97865.93734374212 86239.10565076802 90238.8980402877 88073.73590746423 94425.95387033049 101756.13492174882 106107.97540641791 97837.86598906583 101852.37160564307 83886.95608520856 1.166640702093593 1.0280395150250803 1.07572025796987 1.0499097835663858 1.1256333317711147 1.2130149867208146 1.264892426167404 1.1663060689636489 1.2141622054111256 1.0 16.356158877292252 -6.547932533645826 4.41591573943878 1.1873124905612278 1.0767210601475183 0.24222973604271447 0.07361017193453125 0.2313717067842307 10.75967230793634 0.02331590789482038 0.02410389782463965 2.831831878278676e-07 6.547932533645826 -0.11059143041370945 NCPS(ph)PVLIDCPHPNCNKK ddPTM_A459_Selumetinib_30min_R1 2 NCPSPVLIDCPHPNCNKK 18 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 NCPS(1)PVLIDCPHPNCNKK;NCPS(1)PVLIDCPHPNCNKK 103.13 0.0010944 93971000.0 5583.4 5942.700000000001 8262.5 9089.7 7211.0 6300.700000000001 6977.4 6181.299999999999 3712.5 5528.1 True False 5713.482356594823 5246.92592131372 7140.497882663762 7502.354529801192 6558.766323205451 6237.320678577878 6451.089100463035 6017.35184430788 6299.8413497281545 6237.685483253944 0.915961917594847 0.8411655149013084 1.1447351588715977 1.2027465235210164 1.0514743554822537 0.9999415160195164 1.034211987408151 0.9646770201002304 1.0099645720581902 1.0 12.60679509559968 -5.250163587649506 24.996625127842684 1.0527251723397948 0.8785636988637466 0.49107468367741147 0.07018604797020364 674.9298974992859 1496204.9220413966 0.02008748305535799 0.052185746671842476 5.621295454508453e-06 5.250163587649506 -0.17416147347604816 NCPS(ph)PVLIDCPHPNCNKK ddPTM_A459_Selumetinib_30min_R2 4 NCPSPVLIDCPHPNCNKK 18 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 NCPS(1)PVLIDCPHPNCNKK;NCPS(1)PVLIDCPHPNCNKK;NCPS(1)PVLIDCPHPNCNKK;NCPS(1)PVLIDCPHPNCNKK 121.45 0.0004781000000000001 186591000.0 583627.0 572832.0 586677.0 569974.0 593752.0 440475.0 468789.0 481367.0 317707.0 599994.0 True False 551191.347783992 616766.3724548134 548930.8405456207 492342.557940007 519159.5655497719 501146.43301605905 490588.6173877812 482767.69827540265 381257.277475276 582670.614248373 0.945974165000601 1.0585163510441022 0.9420946022028662 0.8449757820292922 0.8910000828160377 0.8600853050784488 0.8419656069675409 0.8285430678500203 0.6543272788298858 1.0 19.15232102770456 -5.635961274048978 3.078749235064366 0.8400372362918126 1.003292030311668 0.3693903832548613 0.0835846493071877 0.24683621969725827 4.641015206067482 0.02317028733230437 0.04441228623537906 2.312270965717001e-06 5.635961274048978 0.16325479401985532 NCS(ph)ASTSQER ddPTM_A459_Selumetinib_30min_R2 1 NCSASTSQER 10 0 H7BZV4;A0A0C4DG62;Q66PJ3-4;Q66PJ3-3;F8WEP2 H7BZV4 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 NCS(0.65)AS(0.224)T(0.12)S(0.006)QER 95.417 0.022788 58871000.0 3648.7 2630.0 3805.1 4629.5 4479.5 4981.6 8906.1 17287.0 6063.6 10117.0 True False 3445.919860903374 2831.712543217129 3560.284008679632 3998.9541136670523 3916.7451627619025 5667.770181537665 9320.251297102355 17337.30230798309 7276.489431139658 9824.895922877187 0.35073347218667006 0.2882180702416919 0.3623737123148084 0.40702254202566374 0.39865513014156156 0.5768783940337027 0.9486361352083362 1.7646296148148835 0.7406174567403218 1.0 13.262226409351983 -7.250318138546502 2.579658224404728 1.2085838733956658 0.3684496466285756 0.6767450145630954 0.24662585978243715 0.15232946917859821 2.0056447329064473 0.10777129199966735 0.07262199689764448 5.619295379156162e-08 7.250318138546502 -0.8401342267670902 NCS(ph)SPEFSK ddPTM_A459_Selumetinib_30min_R2 1 NCSSPEFSK 9 0 Q5JX53;Q5JX54;F2Z2V0;A6PVH9;E7ENH5;Q5JX45;Q5JX52;Q5JX44;Q5JX60;Q5JX61;Q5JX59;Q5JX58;Q5JX56;Q5JX55;E7EV27;Q5JX57;Q99829;B0QZ18 Q5JX53 CPNE1 Copine-1 1 NCS(0.921)S(0.079)PEFSK 151.55 0.0012017999999999998 16130000.0 105750.0 109210.0 105630.0 121930.0 119790.0 89363.0 92560.0 96530.0 70644.0 103110.0 True False 99872.83835079112 117586.05583450303 98833.8808012482 105322.92365901818 104740.9092638125 101671.9420934538 96864.22340416054 96810.88631859822 84774.77395828073 100132.94638804672 0.9974023730786109 1.1742993697480948 0.9870265918096105 1.0518308654462105 1.0460184488920208 1.0153695238272824 0.967356168955432 0.9668235062556286 0.846622185966163 1.0 16.61155721154995 -7.2588890389529634 1.2368115229609429 0.9265841311941384 1.0578729089467576 0.42319145392897894 0.05932134532543539 0.42334880556305093 1.2624805586817665 0.037001576289094146 0.021273068710852543 5.509484442382379e-08 7.2588890389529634 0.13128877775261916 NCSASTS(ph)QER ddPTM_A459_Selumetinib_30min_R2 1 NCSASTSQER 10 0 H7BZV4;A0A0C4DG62;Q66PJ3-4;Q66PJ3-3;F8WEP2 H7BZV4 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 NCS(0.024)AS(0.024)T(0.195)S(0.757)QER 116.54 0.006304 48311000.0 19314.0 13338.0 18854.0 23913.0 21107.0 19440.0 37933.0 66712.0 24461.0 43082.0 True False 18240.60520006789 14360.981711570375 17640.95416668307 20656.008147774108 18455.34996102589 22117.68354125024 39696.95966281353 66906.1208752339 29353.88349744495 41838.110719521144 0.43598061399930876 0.34325120003255116 0.4216479631440915 0.4937127368453631 0.44111336873571716 0.5286491947383849 0.948822950657077 1.5991668773900045 0.7016063343354745 1.0 15.352530084931677 -7.297395716729583 3.313565783294474 1.135748659828115 0.43263833576281363 0.6767134576944771 0.2106881473174136 0.13176900566956898 2.9792384979712625 0.08837768352536407 0.059212448448051985 5.042016740307282e-08 7.297395716729583 -0.7031103240653014 NCSASTSQAS(ph)PSPCITER ddPTM_A459_Selumetinib_30min_R1 2 NCSASTSQASPSPCITER 18 0 F5H7X4;Q66PJ3-7 F5H7X4 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 NCSAST(0.002)SQAS(0.997)PSPCITER;NCSAST(0.001)S(0.001)QAS(0.975)PS(0.023)PCITER 285.34 1.0560999999999993e-150 6625400.0 2331.53 2790.3999999999996 3309.7 3121.2 2576.79 2607.9 2662.8999999999996 2176.77 1482.51 2058.76 True False 2385.8501126323604 2463.698670778233 2860.260918880758 2576.1410121803215 2343.7197994692233 2581.666893783743 2462.03530908691 2119.034988454545 2515.7111917536663 2323.0219000206007 1.0270458976780212 1.0605576601565334 1.2312673069743307 1.1089611390049643 1.0089099028504376 1.111339886103032 1.0598416265748836 0.9121889847167404 1.0829476862578682 1.0 11.181787039713752 -7.534678410661978 24.5770481215129 0.9957440254006997 1.0927134608636646 0.26944854108384697 0.06839692709100807 246.38702846311358 513181.04973091435 0.03280474239688493 0.018958556845321453 2.9195881302813892e-08 7.534678410661978 0.09696943546296488 NCSASTSQAS(ph)PSPCITER ddPTM_A459_Selumetinib_30min_R2 4 NCSASTSQASPSPCITER 18 0 F5H7X4;Q66PJ3-7 F5H7X4 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 NCSAST(0.003)S(0.06)QAS(0.922)PS(0.015)PCITER;NCSAS(0.001)T(0.006)S(0.017)QAS(0.488)PS(0.488)PCIT(0.001)ER;NCS(0.001)AST(0.002)S(0.076)QAS(0.61)PS(0.31)PCITER;NCSAS(0.006)T(0.021)S(0.002)QAS(0.97)PS(0.001)PCITER 291.28 8.015799999999996e-81 39163300.0 70018.0 58669.0 59625.0 64253.0 68534.0 43558.0 54302.0 56422.0 47334.399999999994 63523.0 True False 66126.67986426184 63168.72364943189 55788.792414791445 55501.63055739262 59924.14621826633 49557.71911984456 56827.15059737167 56586.178678835044 56802.602633639624 61688.925937424916 1.071937610509517 1.0239880608961816 0.9043566826140179 0.8997016841189864 0.9713922767767311 0.8033487107574895 0.9211888476550093 0.9172826049238413 0.9207909162052553 1.0 15.91272390735071 -5.143801825464541 3.27162800240724 0.9113700090693337 1.0648541479340643 0.5399859274542231 0.04878564158457 0.17618969912748594 3.443389402821596 0.012351878787427066 0.04225206156168092 7.181219054043453e-06 5.143801825464541 0.15348413886473056 NCSETQYESK ddPTM_A459_Selumetinib_30min_R1 1 NCSETQYESK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 135.99 0.026386 7522500.0 920.14 908.47 906.22 893.57 742.85 898.87 1025.7 892.1 692.62 706.75 False True 941.5774717192324 802.1059100637552 783.1603015101431 737.524773886316 675.6593486608194 889.8281839086602 948.3306232041929 868.4386100508084 1175.3255530366919 797.4682468279739 1.1807084175005969 1.0058154832549486 0.9820582883710514 0.9248327777562426 0.8472554880377193 1.1158164446647991 1.1891766562195953 1.0889945944620714 1.4738211304483797 1.0 9.639283265322044 -6.972217618004087 8.717187652991539 1.1894573261443053 0.9846269478765461 0.32361910920278636 0.13718860516512968 0.2896316464903184 81.69010463124715 0.04802648954518293 0.042063747535548715 1.0660618008899823e-07 6.972217618004087 -0.20483037826775918 NCSETQYESK ddPTM_A459_Selumetinib_30min_R2 1 NCSETQYESK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 139.86 0.020521 3575300.0 9497.2 8026.3 7493.1 10043.0 8063.9 4208.1 6355.1 7405.6 5407.1 7210.5 False True 8969.383644303867 8641.891401377812 7011.002103870422 8675.126074858676 7050.840789819332 4787.72757767156 6650.624742391752 7427.14906993692 6488.671086997043 7002.314129871107 1.2809170622668093 1.234147917545208 1.001240728970192 1.2388941589826048 1.006930088974617 0.6837350465680534 0.9497752627264912 1.060670648615079 0.9266466723218088 1.0 12.773616068428185 -6.434281832895358 5.243172638112352 0.9212600928476649 1.1761094233123364 0.5396421398903832 0.11510506340270134 0.19117355160162022 8.554922410885663 0.03810265397737242 0.042958775709983986 3.67890155969614e-07 6.434281832895358 0.2548493304646715 NCSS(ph)PEFSK ddPTM_A459_Selumetinib_30min_R1 1 NCSSPEFSK 9 0 Q5JX53;Q5JX54;F2Z2V0;A6PVH9;E7ENH5;Q5JX45;Q5JX52;Q5JX44;Q5JX60;Q5JX61;Q5JX59;Q5JX58;Q5JX56;Q5JX55;E7EV27;Q5JX57;Q99829;B0QZ18 Q5JX53 CPNE1 Copine-1 1 NCS(0.145)S(0.852)PEFS(0.003)K 114.76 0.008380799999999999 9994000.0 4181.1 5471.3 4595.7 5761.9 4482.1 4258.7 4474.9 4093.6 2610.3 4006.1 True False 4278.5114949956305 4830.717652461637 3971.6291823731135 4755.692329258554 4076.694846379027 4215.861344590219 4137.354690237338 3985.0244301132043 4429.488451231085 4520.321957718497 0.9465059203780888 1.0686667227791453 0.8786164391656914 1.0520693821682678 0.9018593995098131 0.932646254851735 0.9152787630918107 0.881579778473242 0.9799055228063316 1.0 12.14220981621008 -6.293604263271186 24.985990363519733 0.9281656980647073 0.9846327968512136 0.1455317704990976 0.05931957567445471 1105.6419742014905 858870.3825796138 0.017190179658040306 0.019493409491305777 5.086226973644955e-07 6.293604263271186 0.05646709878650635 NCSS(ph)PEFSK ddPTM_A459_Selumetinib_30min_R2 1 NCSSPEFSK 9 0 Q5JX53;Q5JX54;F2Z2V0;A6PVH9;E7ENH5;Q5JX45;Q5JX52;Q5JX44;Q5JX60;Q5JX61;Q5JX59;Q5JX58;Q5JX56;Q5JX55;E7EV27;Q5JX57;Q99829;B0QZ18 Q5JX53 CPNE1 Copine-1 1 NCS(0.225)S(0.775)PEFSK 190.35 0.0019944000000000003 13218000.0 124810.0 132190.0 126260.0 145470.0 147290.0 102140.0 108560.0 102190.0 92957.0 133620.0 True False 117873.55985401645 142328.54794215673 118136.56906149402 125656.73505025308 128786.11341069316 116208.85786539607 113608.25510755903 102487.35598153471 111550.99743559113 129762.04341354646 0.9083824264261785 1.0968426837157714 0.9104092842079983 0.9683627950416137 0.9924790795738084 0.89555354407485 0.8755122231351895 0.7898099728201072 0.8596581442547305 1.0 16.98550891796544 -6.890175580403489 3.593653029952749 0.8656256578796911 0.9781676843016677 0.2918971674668681 0.06924726039872699 0.2545785377648408 6.347187392952204 0.024775355546168974 0.021625518692350514 1.28772883207006e-07 6.890175580403489 0.11254202642197653 NCVAIAADRR ddPTM_A459_Selumetinib_30min_R1 2 NCVAIAADRR 10 1 A0A087WXQ8;A0A087WY10;A0A087WUL2;P49720 A0A087WXQ8 PSMB3 Proteasome subunit beta type-3 0 ; 125.68 0.0048499 3890400.0 2515.58 2460.3 2439.52 2835.19 2330.11 2286.69 2188.64 2218.77 1354.41 1928.17 False True 2574.1881195334026 2172.2469322375623 2108.2465833241636 2340.0772896076915 2119.3519619143335 2263.6879747483995 2023.5491227158275 2159.9210120193175 2298.3348478074927 2175.669401466281 1.183170622245522 0.9984269350727586 0.9690105408033599 1.0755665764433735 0.9741148910243473 1.0404558584235264 0.9300811609300875 0.9927615889452919 1.0563805540761577 1.0 11.087243636700528 -4.760579320506824 24.991064920192542 1.0028870184047665 1.1831708334971738 0.629747543804114 0.04118518107067351 13.307348187457462 386452.31190108723 0.00993007814035743 0.05839328229639937 1.735484261231078e-05 4.760579320506824 0.18028381509240732 NCVAIAADRR ddPTM_A459_Selumetinib_30min_R2 4 NCVAIAADRR 10 1 A0A087WXQ8;A0A087WY10;A0A087WUL2;P49720 A0A087WXQ8 PSMB3 Proteasome subunit beta type-3 0 ;;; 136.49 0.0025032 8843000.0 62002.1 61363.1 61412.7 73253.7 61527.9 48524.9 48652.5 50542.7 38544.7 54262.6 False True 58556.271496071706 66069.45245653507 57461.47374309206 63276.41969031917 53798.215135595005 55208.764509815475 50914.93765309979 50689.77088920558 46254.71702890177 52695.897746833616 1.1112111947953336 1.2537873967714128 1.0904354266655376 1.2007845467272888 1.0209184668236841 1.0476861932413486 0.9662030600125635 0.9619301132838451 0.8777669421464808 1.0 15.685403035327374 -6.667520505377303 0.991275565502741 0.9400429774325287 1.1755159204063996 0.7237539522015102 0.056935440433781626 0.25619717304926376 0.5440047234920321 0.0293588654871416 0.0295104645013704 2.1502031542928724e-07 6.667520505377303 0.2354729429738709 NCWQNYLDFHR ddPTM_A459_Selumetinib_30min_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 116.84 0.0081106 14768000.0 3751.4 5485.1 4577.1 4677.8 2587.0 4101.1 3176.7 3018.8 2730.1 2766.1 False True 3838.8003210462807 4842.901942046189 3955.554960210627 3860.9100431811853 2353.0063067719457 4059.846657500868 2937.078961424157 2938.731617555633 4632.7803013852745 3121.155879095663 1.229929061459933 1.5516373195206745 1.2673365616576404 1.2370128864886627 0.7538893915973578 1.3007510085261058 0.9410228374352001 0.9415523387467318 1.4843155807801551 1.0 11.607864695870663 -5.8294025857341065 2.8283640016063156 1.0693628690219328 1.3825169937194195 0.2634357206562552 0.207712859007626 0.32272206571457407 5.232122006609701 0.058859578232264724 0.09904857418989899 1.4811444455766599e-06 5.8294025857341065 0.3131541246974867 NDAPTPGTSTT(ph)PGLR ddPTM_A459_Selumetinib_30min_R1 1 NDAPTPGTSTTPGLR 15 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 NDAPTPGT(0.006)S(0.042)T(0.311)T(0.64)PGLR 119.92 0.0038821 0.0 1817.6 2164.1 2071.0 2218.9 1707.3 1561.8 1582.7 1534.8 950.96 1769.2 True False 1859.9465435660616 1910.7261659372043 1789.7695751887027 1831.410768911609 1552.875016448296 1546.0897100009413 1463.315664760919 1494.0921182669897 1613.7096646296266 1996.2940534673521 0.9316996863941616 0.9571366315591006 0.8965460634820115 0.9174053119732746 0.7778788970247725 0.7744799456350364 0.7330160916019832 0.7484328852615222 0.8083526882358755 1.0 10.96310852950216 -6.240957755824305 6.957304881824262 0.7890341693724513 0.9263405246669724 0.38020295377670155 0.07206932209500815 0.1606747270926749 36.175517687253596 0.020447961465673126 0.025715978069365462 5.741723096963145e-07 6.240957755824305 0.13730635529452107 NDAPTPGTSTT(ph)PGLR ddPTM_A459_Selumetinib_30min_R2 2 NDAPTPGTSTTPGLR 15 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 NDAPT(0.005)PGT(0.004)S(0.004)T(0.023)T(0.965)PGLR;NDAPT(0.049)PGT(0.051)S(0.169)T(0.169)T(0.563)PGLR 128.82 0.002191 6147800.0 46724.0 46384.0 41576.0 45212.0 44095.0 38772.0 40963.0 37223.0 35206.0 44756.0 True False 44127.26713099163 49941.50365193287 38901.045424526135 39054.04760494975 38555.391885698395 44112.49106282683 42867.860666644636 37331.31276740064 42248.18373782948 43463.777989946764 1.0152653352223162 1.1490373354908174 0.895022182230086 0.8985424049879651 0.8870695017496251 1.014925372410795 0.986289334455924 0.8589063006910128 0.9720320158915211 1.0 15.407525962500957 -5.2678360153735495 24.99855787370082 0.9351462214798476 1.0821513377335605 0.4854850421963899 0.058794610904675804 364.1316596032068 1423059.900984152 0.015281734044149436 0.03301875647862246 5.397143740169129e-06 5.2678360153735495 0.14700511625371293 NDDDEEEAAR ddPTM_A459_Selumetinib_30min_R2 1 NDDDEEEAAR 10 0 E7EX44;Q05682-3;Q05682-6;Q05682-2;C9JE79;F8WE61;C9JEK3;Q05682;Q05682-5;Q05682-4;E9PGZ1;C9J813 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 0 135.8 0.026676 11683000.0 9456.1 7886.1 7212.8 9283.7 9224.5 6848.1 6904.7 8599.5 6654.5 10065.0 False True 8930.567817767524 8490.938512191873 6748.736300702854 8019.24404472423 8065.635841923689 7791.3636141376355 7225.782231403489 8624.523121276134 7985.585942265132 9774.397297989422 0.9136694105532754 0.8686917723242583 0.6904503771389626 0.8204336083590316 0.8251798649091927 0.7971195948562789 0.7392560391309059 0.8823585596474766 0.8169901119026289 1.0 13.254792031377836 -9.262176445329528 1.0006239479610048 1.0008148150644383 0.8101867901120591 0.4354648770139703 0.062375867841752905 3.6039612256666227 4.083793365201583 0.06900032165485667 0.019585701742185973 5.467937661778326e-10 9.262176445329528 -0.19062802495237918 NDDDEEEAARER ddPTM_A459_Selumetinib_30min_R1 1 NDDDEEEAARER 12 1 E7EX44;Q05682-3;Q05682-6;Q05682-2;C9JE79;F8WE61;C9JEK3;Q05682;Q05682-5;Q05682-4;E9PGZ1;C9J813 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 0 109.16 0.021859 1014800.0 385.15 433.97 1122.0 832.83 522.93 605.9 436.79 373.57 545.09 313.38 False True 394.12324562855895 383.1605906528205 969.6385627048406 687.3918746553046 475.63107383078994 599.8051961131833 403.8425786383536 363.66171007362476 924.9779182015677 353.6053755796966 1.11458499459302 1.083582482377909 2.7421488180580575 1.943951993174318 1.3450900542760296 1.6962558760026472 1.14207137823145 1.0284394276456965 2.615848010469777 1.0 8.465996396809558 -6.271039957606581 24.08263186202387 1.4674940500590201 1.7484668746410765 0.037416562514369645 0.6142269054872338 1614.6930058637017 4050379.125383929 0.19523234477665175 0.2243927867301191 5.35747363386689e-07 6.271039957606581 0.2809728245820564 NDELLSDLTRT(ph)PPPPSSTFPK ddPTM_A459_Selumetinib_30min_R1 2 NDELLSDLTRTPPPPSSTFPK 21 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 NDELLS(0.001)DLT(0.004)RT(0.995)PPPPSSTFPK;NDELLS(0.032)DLT(0.098)RT(0.865)PPPPS(0.001)S(0.002)T(0.001)FPK 90.836 0.00097863 33656000.0 3341.5 3075.7 6596.0 7267.3 4697.4 4387.9 2902.8999999999996 2590.6 2390.29 2266.5 True False 3419.35044857284 2715.595614145862 5700.299429234518 5998.202479116382 4272.5209993933295 4343.761709894433 2683.9319158618027 2521.8888725452575 4056.1475501257146 2557.4273525795597 1.3370274018239063 1.0618466293506892 2.2289193956907076 2.3454048354750996 1.6706324013793914 1.6984887979371455 1.0494655549666518 0.9861038164003149 1.5860264988698367 1.0 11.320477543376855 -7.230631089089964 7.826181641374842 1.154245275859792 1.7434433510480942 0.342392219443417 0.3852921633301735 0.32622482757470816 73.51943918564847 0.16396472002556084 0.12503977884280443 5.879886066484019e-08 7.230631089089964 0.5891980751883021 NDFTEEEEAQVR ddPTM_A459_Selumetinib_30min_R2 1 NDFTEEEEAQVR 12 0 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 142.12 0.012956 7491600.0 20234.0 16368.0 16867.0 21406.0 23096.0 12352.0 16298.0 17573.0 11651.0 16795.0 False True 19109.475283119682 17623.372968584797 15781.795583401059 18490.465872590332 20194.47399914028 14053.375879707959 17055.889293874323 17624.134520633233 13981.525556139612 16310.084711349462 1.171635562985289 1.0805200144865879 0.9676096637572464 1.1336830065464736 1.2381587439020376 0.8616372096417648 1.0457265915980123 1.080566706583037 0.8572319398445852 1.0 13.993476654690994 -6.76472235303088 24.999997822457566 0.9788613113642056 1.1087018621321623 0.3895207635693747 0.0926510005309972 109.6000013342233 834601.8032088648 0.032892491313919955 0.030201460658124023 1.7190070070452267e-07 6.76472235303088 0.12984055076795664 NDILEEPVDSDSTKTLTKQQS(ph)TTFPK ddPTM_A459_Selumetinib_30min_R2 1 NDILEEPVDSDSTKTLTKQQSTTFPK 26 2 Q9H582;Q9H582-2;A0A087WZL9 Q9H582 ZNF644 Zinc finger protein 644 1 NDILEEPVDS(0.018)DS(0.055)T(0.055)KT(0.055)LT(0.055)KQQS(0.623)T(0.07)T(0.07)FPK 45.737 0.02297 14271000.0 59340.0 54327.0 43639.0 35878.0 30076.0 27207.0 36578.0 26376.0 14580.0 38715.0 True False 56042.1203568411 58493.70621116242 40831.31425055071 30991.354506997868 26297.583997148555 30954.51728944419 38278.949477931965 26452.749793218147 17496.40739923746 37597.19735634978 1.4905930307961148 1.5557996426370178 1.0860201589907796 0.8242995937505364 0.6994559660364461 0.8233198074860303 1.0181330569701905 0.7035830235561574 0.4653646715579585 1.0 15.198337501271622 -5.467215417851421 2.336347897280647 0.7826992314407818 1.5393914371727153 0.7890107524081685 0.15041518373679746 0.13398390931146617 1.4209309883932801 0.04413551227769306 0.11262711054322697 3.410237157845526e-06 5.467215417851421 0.7566922057319335 NDKS(ph)EEEQSSSSVK ddPTM_A459_Selumetinib_30min_R1 4 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKS(1)EEEQSSSSVK;NDKS(0.993)EEEQS(0.007)SSSVK;NDKS(0.986)EEEQS(0.006)S(0.006)S(0.001)SVK;NDKS(1)EEEQSSSSVK 237.34 1.0914e-18 1248181700.0 12606.07 12431.109999999999 12943.740000000002 12687.81 9216.64 12601.33 11108.15 12436.91 9145.72 12728.96 True False 12899.766903857731 10975.669862133742 11186.051202874462 10472.122163190956 8382.996539329952 12474.572061292201 10270.253302277124 12107.042746022864 15519.618863039937 14362.846006570086 0.8981344573322663 0.764170962851866 0.7788185710379096 0.7291119154518978 0.5836584570700867 0.8685306558035838 0.7150569808782423 0.8429417638039609 1.0805392507822407 1.0 13.810054027926494 -8.112059513658464 3.787042819845425 1.0378213357232338 0.7597162246435301 0.6321601974304087 0.08334425279295149 0.15093045688199086 3.7068129881830405 0.0635522949072186 0.021798829723048408 7.7257470786328e-09 8.112059513658464 -0.2781051110797037 NDKS(ph)EEEQSSSSVK ddPTM_A459_Selumetinib_30min_R2 5 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKS(1)EEEQSSSSVK;NDKS(0.998)EEEQS(0.001)S(0.001)SSVK;NDKS(1)EEEQSSSSVK;NDKS(1)EEEQSSSSVK;NDKS(0.999)EEEQSSSSVK 172.93 0.00053934 2590944700.0 310233.0 213437.0 205281.0 240515.0 188461.0 179643.0 263221.0 220299.0 141286.0 185761.0 True False 292991.4918210966 229806.93159187623 192073.44395305356 207756.44208848287 164784.84431728313 204387.19261321044 275461.29806251626 220940.0336175374 169547.1478606769 180397.59726495898 1.6241429834055126 1.273891310505357 1.064722850332345 1.1516585876880643 0.9134536535719785 1.1329817897353518 1.5269676660822287 1.2247393367054202 0.9398525835776765 1.0 17.46082059774733 -4.806957315380231 2.840217251662056 1.1366520797571327 1.6966574005688357 0.45867744219675477 0.165438653576054 0.3916691043204507 4.590216403685152 0.045409159261501554 0.5024684119393308 1.559705790929464e-05 4.806957315380231 0.5600053208117031 NDKS(ph)EEEQSSSSVKK ddPTM_A459_Selumetinib_30min_R1 2 NDKSEEEQSSSSVKK 15 2 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKS(1)EEEQSSSSVKK;NDKS(1)EEEQSSSSVKK 102.79 0.006859100000000001 59438000.0 9270.6 6406.5 11280.5 9144.7 7275.8 9302.0 7198.2 9186.9 7046.8 8424.4 True False 9486.586942552558 5656.424001698953 9748.67005935111 7547.749812279062 6617.705174646825 9208.430325540246 6655.233978695932 8943.233568743159 11957.904922091413 9505.753800605002 0.9979836572191441 0.5950526513046178 1.025554654984926 0.7940190720907035 0.6961788947474776 0.9687217361924699 0.7001269040096908 0.9408231852348163 1.2579649308117302 1.0 13.214585320928265 -8.031319830701264 6.460030695163129 1.1226777643003927 0.823032970079495 0.4084940580400147 0.14502157110042221 0.1762107650940124 23.98275546107501 0.08769377961404672 0.03446087778481366 9.304224252268114e-09 8.031319830701264 -0.2996447942208976 NDKS(ph)EEEQSSSSVKK ddPTM_A459_Selumetinib_30min_R2 2 NDKSEEEQSSSSVKK 15 2 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKS(1)EEEQSSSSVKK;NDKS(1)EEEQSSSSVKK 98.676 0.009865100000000002 42594000.0 70231.0 52228.0 49272.0 59479.0 35992.0 33286.0 49145.0 40049.0 22408.9 42805.0 True False 66327.84217696844 56233.71966051115 46101.893163297376 51377.85759300201 31470.3631874375 37870.84435977649 51430.33987897007 40165.53595953113 26891.306156980274 41569.108429253545 1.5956041561452243 1.3527766600098077 1.109042144643496 1.2359624618950384 0.7570612980790026 0.9110333560371849 1.2372249928453327 0.9662352039108283 0.6469060120148254 1.0 15.343224185041485 -4.258363896123936 0.6055778392561514 0.9260300978242413 2.562523032193745 0.6355800927342934 0.16308980473829232 4.31606530021799 0.7577347357530569 0.08111697874553261 5.662306002174657 5.516150463529433e-05 4.258363896123936 1.6364929343695038 NDKSEEEQS(ph)SSSVK ddPTM_A459_Selumetinib_30min_R1 1 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.451)S(0.451)S(0.038)S(0.059)VK 126.07 0.00073006 18680000.0 2736.3 3060.1 2537.0 2761.0 2270.0 2782.9 2506.4 3104.6 1739.6 2874.3 True False 2800.050466087046 2701.822069398107 2192.489334743475 2278.84318038891 2064.6789008010514 2754.9065526710306 2317.3402300857842 3022.2559228379555 2951.97414464299 3243.2444030529114 0.8633485849698281 0.8330615068216395 0.6760173031300553 0.7026430626824802 0.6366091000904959 0.8494292166442339 0.7145129820942385 0.9318619096337802 0.9101917024397715 1.0 11.663222030560824 -7.770189979718481 24.175813631987932 0.9407702602007922 0.7509471331596741 0.5841922640338653 0.07479742469997822 98.79895815613584 272950.630250674 0.04207784484592464 0.020728983351228115 1.697500927633369e-08 7.770189979718481 -0.18982312704111814 NDKSEEEQS(ph)SSSVK ddPTM_A459_Selumetinib_30min_R2 2 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.401)S(0.256)S(0.256)S(0.087)VK;NDKS(0.413)EEEQS(0.562)S(0.024)S(0.001)SVK 100.88 0.029325 230723100.0 176234.0 123349.0 121351.0 152156.0 107597.0 113088.0 145263.0 160483.0 103080.0 120853.0 True False 166439.61980059862 132809.47167045274 113543.40877697869 131432.09031625997 94079.70293061546 128664.84548934696 152018.01733317378 160949.97896060924 123698.8802958433 117363.65987619653 1.4181529442433107 1.131606425792699 0.9674494549399046 1.1198704135070754 0.8016084623626885 1.0962920347326568 1.295273319641984 1.3713783221347275 1.0539794040704729 1.0 16.840626240360606 -7.100447593941022 7.829765420969378 1.2100569194730408 1.072027431575646 0.04618998757138726 0.17649717035255147 0.6769479579432035 47.11117541113195 0.06894733778357325 0.05341034198472126 7.935100033842506e-08 7.100447593941022 -0.1380294878973949 NDKSEEEQSSS(ph)SVK ddPTM_A459_Selumetinib_30min_R1 1 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.003)S(0.001)S(0.769)S(0.227)VK 124.99 0.00077879 11747000.0 4383.9 4793.5 4033.9 3275.7 2997.2 4231.1 3762.4 5320.7 4187.4 5822.3 True False 4486.036340415522 4232.274791562309 3486.1185366266077 2703.6604875045095 2726.103789198638 4188.538975531424 3478.5991388743837 5179.577751930653 7105.711964404494 6569.648919004619 0.6828426291454264 0.6442162806172524 0.530640005212759 0.41153804728946564 0.41495425749655973 0.6375590274565293 0.5294954390654765 0.7884101290324996 1.0815969090599586 1.0 12.68160055987568 -7.9996634711656025 2.6928879002492225 1.0396359529241421 0.5447336310525108 0.8301165544501676 0.08889712821434494 0.1184343088046877 1.644651005053407 0.0754000826287473 0.026757209549096887 1.0007751865793795e-08 7.9996634711656025 -0.4949023218716313 NDKSEEEQSSS(ph)SVK ddPTM_A459_Selumetinib_30min_R2 3 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQSS(0.001)S(0.874)S(0.126)VK;NDKSEEEQS(0.056)S(0.056)S(0.693)S(0.196)VK;NDKSEEEQS(0.282)S(0.282)S(0.412)S(0.023)VK 140.68 0.0026608 20852900.0 88791.0 58007.0 56493.0 74228.0 62181.0 67473.0 105003.0 111908.0 58971.0 78400.0 True False 83856.35167853512 62455.95037809741 52858.30188492771 64118.018349557766 54369.26687480692 76766.79329108926 109885.84755949721 112233.63375263338 70766.84778740947 76136.38829233684 1.1013965011914717 0.8203166945388666 0.6942580685856873 0.8421468339602245 0.7141035724737578 1.0082799435708967 1.4432763363764298 1.4741129211658408 0.9294747147144644 1.0 16.216298513459066 -7.02102961373345 5.751823723037095 1.2500340658605533 0.8282707530035401 0.46329951452376594 0.1894789538607513 0.1426386715825525 15.774763553452269 0.0710999379680685 0.05752066504251798 9.527311968393146e-08 7.02102961373345 -0.4217633128570132 NDKSEEEQSSS(ph)SVKKDETNVK ddPTM_A459_Selumetinib_30min_R2 1 NDKSEEEQSSSSVKKDETNVK 21 3 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.005)S(0.107)S(0.444)S(0.444)VKKDETNVK 71.592 0.0037151 13592000.0 25889.0 17073.0 14180.0 16232.0 10951.0 10499.0 15968.0 16188.0 7772.7 12945.0 True False 24450.19302187832 18382.444201652506 13267.67423801665 14021.173598238174 9575.23747681785 11945.141949567189 16710.54363999173 16235.104399932341 9327.457187383608 12571.24421485077 1.9449302395219248 1.4622613233411534 1.0553986551580286 1.1153369832458238 0.7616777872715533 0.9501956803492888 1.3292672828876466 1.2914476978144571 0.7419677024780742 1.0 13.617839824356606 -4.883146450146802 1.798780097995967 1.0358939417029722 2.13835577873196 0.7177546649288926 0.18165140231539392 0.39345421368004607 1.552686720250486 0.053068727699902736 0.6980371704127127 1.3087405230520416e-05 4.883146450146802 1.1024618370289878 NDKSEEEQSSSS(ph)VK ddPTM_A459_Selumetinib_30min_R1 2 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.001)S(0.001)S(0.133)S(0.866)VK;NDKSEEEQSSS(0.226)S(0.774)VK 295.22 1.5922999999999993e-66 20049900.0 5965.700000000001 6560.9 5602.700000000001 3573.3999999999996 3493.2 5805.0 5198.299999999999 6940.9 5148.8 6838.9 True False 6104.689202768516 5792.7467779203425 4841.884113428173 2949.372771025618 3177.2406767745506 5746.606970518289 4806.188045824658 6756.804784779344 8737.137546526692 7716.739431527178 0.7910969726187024 0.7506728495008845 0.6274520678573622 0.38220453044919306 0.4117335702426018 0.7446936651819808 0.6228262711824509 0.8756035945925599 1.132231770173633 1.0 12.913775676245788 -7.9187590968049575 2.5388679885942587 1.0652700978363252 0.6080782713892944 0.6560624788104167 0.13170947352330822 0.1945309895332286 2.4285389774037234 0.10725150392868826 0.040683815285524755 1.2057045593597334e-08 7.9187590968049575 -0.4571918264470308 NDKSEEEQSSSS(ph)VK ddPTM_A459_Selumetinib_30min_R2 4 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.005)S(0.005)S(0.235)S(0.756)VK;NDKSEEEQSSS(0.13)S(0.87)VK;NDKSEEEQSSS(0.044)S(0.956)VK;NDKSEEEQSSS(0.002)S(0.998)VK 184.21 4.2865e-05 67950800.0 116776.0 59996.4 63161.6 85177.0 67030.0 66624.1 154205.0 166470.0 94272.5 93458.0 True False 110286.05741136617 64597.9309611682 59097.85142115038 73575.74566147946 58609.09214419694 75800.96502163626 161375.8380514105 166954.400139408 113129.63419373184 90759.62470695446 1.2151444848682311 0.7117474446345785 0.6511469346856169 0.8106660411944356 0.6457617286699293 0.8351837644369193 1.7780575732046309 1.839522812907964 1.2464753414197765 1.0 16.46976302299629 -7.2452753701723545 21.689252261595843 1.5359739409899245 0.7921938645634872 0.5726502811965672 0.273990649014389 89.65275723031021 120298.14217366424 0.10255451053653164 0.07903454752435876 5.684923564290832e-08 7.2452753701723545 -0.7437800764264373 NDKSEEEQSSSSVK ddPTM_A459_Selumetinib_30min_R1 1 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 141.65 0.0068185 0.0 297.61 126.71 196.48 254.42 172.45 201.82 210.06 154.91 147.7 231.33 False True 304.54373395174713 111.87473429411915 169.7990951873859 209.99032305488834 156.85192794852034 199.7898740378984 194.21500507972374 150.80128358140428 250.63611241881446 261.0234588450163 1.1667293633273443 0.4286003058466297 0.6505127774289619 0.804488316812823 0.600911230900713 0.7654096490864616 0.7440519175521295 0.577730768907415 0.9602053146021279 1.0 8.028035661085221 -8.362698014529004 6.358070516713692 0.9934507444674989 0.7073459334250654 0.24738221479158296 0.1829544265891532 0.3219274585588144 16.620790263412484 0.16381538892019035 0.04250994550666659 4.338124238092192e-09 8.362698014529004 -0.28610481104243357 NDKSEEEQSSSSVK ddPTM_A459_Selumetinib_30min_R2 2 NDKSEEEQSSSSVK 14 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 ; 134.37 0.0018315 11049800.0 65945.0 44104.0 43632.0 52304.0 43747.0 44411.0 58974.0 62250.0 40233.0 57092.0 False True 62280.04089875102 47486.63498328834 40824.76462292968 45180.10497056738 38251.11075685788 50528.2121270815 61716.40785476404 62431.13719395776 48280.724203945174 55443.60561716956 1.1233043054376028 0.8564853323425067 0.7363295400522658 0.8148839612367522 0.6899102309647125 0.9113442671093909 1.113138425392232 1.1260295303490206 0.8708077995020185 1.0 15.758733461643333 -7.024892254780628 8.620903950403422 1.0346629790266446 0.8335748206412507 0.3199295450433709 0.12548970213703486 0.33033294225617804 104.91478667446431 0.04849160666290376 0.03870223846802628 9.442951197986606e-08 7.024892254780628 -0.20108815838539396 NDKSEEEQSSSSVKKDET(ph)NVK ddPTM_A459_Selumetinib_30min_R1 1 NDKSEEEQSSSSVKKDETNVK 21 3 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 NDKSEEEQS(0.029)S(0.112)S(0.091)S(0.091)VKKDET(0.677)NVK 49.089 0.034835000000000005 78974000.0 1604.3 1712.5 3592.2 2319.0 1840.2 1786.3 1636.6 1955.2 1462.7 1682.0 True False 1641.6770685756132 1511.9997038803483 3104.3989705421814 1914.0301830213282 1673.7542349136982 1768.3314438306318 1513.1499443657804 1903.3417446153348 2482.095068618822 1897.9010840674237 0.8649961172145535 0.7966693926113138 1.635701141963148 1.0084983875552345 0.8818975071802201 0.931730035182282 0.7972754518496419 1.0028666723432451 1.3078105542251983 1.0 10.890189087746013 NDLQDTEIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 NDLQDTEISPR 11 0 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 NDLQDTEIS(1)PR;NDLQDTEIS(1)PR 132.51 0.0019981 88274000.0 4517.1 6107.2 3898.2 4259.1 4591.9 4588.1 5256.5 5160.799999999999 3092.0 5819.299999999999 True False 4622.339641253446 5392.166184839745 3368.8458512798643 3515.32813820877 4176.563455765791 4541.947879661492 4859.9979729675715 5023.918819359052 5246.898169255077 6566.263839782139 0.7039527734552332 0.8211924339943445 0.5130536837203359 0.5353619994540768 0.636063910569936 0.6917096221665361 0.7401466178564066 0.7651107146991735 0.7990690440226299 1.0 12.680857004828525 -8.4648983674803 0.6969338954804394 0.9968132716150627 0.642696744247525 0.624150559759046 0.08278669084450119 0.5365596023490685 0.6002706228941678 0.09047258943406015 0.036404796923510147 3.428480096018817e-09 8.4648983674803 -0.35411652736753774 NDLQDTEIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 NDLQDTEISPR 11 0 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 NDLQDTEIS(1)PR;NDLQDTEIS(1)PR;NDLQDT(0.006)EIS(0.994)PR 131.08 0.0022707 116858900.0 171492.0 139832.0 167090.0 178650.0 180103.0 163030.0 181722.0 178636.0 165319.0 146459.0 True False 161961.16117686857 150556.6647692541 156339.61131383633 154317.56181156082 157476.85099875144 185485.90266100943 190172.4330753116 179155.801185218 198387.41939880207 142230.3481238183 1.1387243532292677 1.058541069154857 1.099200088983367 1.084983365696469 1.1071958486782325 1.3041232416835198 1.3370735260364928 1.2596172585421386 1.394831848587591 1.0 17.117869804487917 -6.742466634791866 9.470841998361166 1.2802547859064903 1.0947214501398006 0.3873546608264028 0.09970310987139865 0.21964201002501008 100.24928580216768 0.030860917982598574 0.030212978972004846 1.8093949139055888e-07 6.742466634791866 -0.18553333576668973 NDLS(ph)PTTVMSEGAR ddPTM_A459_Selumetinib_30min_R1 1 NDLSPTTVMSEGAR 14 0 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 NDLS(0.333)PT(0.333)T(0.333)VMSEGAR 121.95 0.0018448 7073200.0 2051.7 1889.2 1619.9 1780.1 1889.9 1433.3 1569.8 2212.2 881.76 1357.5 True False 2099.500618086756 1668.011585734747 1399.9264774737703 1469.2389516154649 1718.9588786889447 1418.8823033322751 1451.3887221467699 2153.525269761685 1496.2823187976564 1531.748348169755 1.3706563617942809 1.088959284811901 0.9139402560130095 0.9591908183684474 1.1222201615186218 0.926315543299041 0.9475373183075375 1.4059262883063492 0.976846046927698 1.0 10.580963580182592 -11.23106338993268 13.60474317776804 0.9999921313628489 1.0734960561371973 0.018301388767730242 0.16935758867387496 4.074310839191924e-05 8.739376846232456e-07 0.16517984083344 0.04005770674548787 5.874036084221805e-12 11.23106338993268 0.07350392477434842 NDLSPTTVMS(ph)EGAR ddPTM_A459_Selumetinib_30min_R1 1 NDLSPTTVMSEGAR 14 0 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 NDLS(0.237)PT(0.237)T(0.237)VMS(0.289)EGAR 98.676 0.010227 5651900.0 1460.5 1927.1 1605.7 2088.2 1654.5 1225.2 1679.2 1899.3 876.32 1449.5 True False 1494.5268083617048 1701.474236115515 1387.6547594787548 1723.5350703687513 1504.8507671256996 1212.875600392594 1552.5365920683248 1848.9243942041264 1487.0510361195363 1635.5574443256435 0.9137721292191684 1.0403023397426738 0.8484292400080748 1.0537906059786128 0.9200843249783651 0.7415671058210215 0.9492400266677585 1.1304551855507932 0.9092013498386553 1.0 10.675566715552266 -7.538913211143695 24.957011174569644 1.0198665086416263 0.9211354434664198 0.1555641894041021 0.09708540336315963 433.12534946486466 674134.0364986577 0.045782204063176755 0.026442626986228304 2.891257609876895e-08 7.538913211143695 -0.09873106517520647 NDMIQDLS(ph)RELANLLMQTEGPELEERYSTLRK ddPTM_A459_Selumetinib_30min_R1 1 NDMIQDLSRELANLLMQTEGPELEERYSTLRK 32 3 Q96MP5 Q96MP5 ZSWIM3 Zinc finger SWIM domain-containing protein 3 1 NDMIQDLS(0.99)RELANLLMQT(0.007)EGPELEERY(0.001)S(0.001)T(0.001)LRK 40.454 0.042408 11839000.0 1930.0 1923.6 2546.1 1809.9 1958.5 2054.7 1881.8 2109.9 1126.8 1918.5 True False 1974.965244873735 1698.3840177426212 2200.3536047261973 1493.8349410307464 1781.3540208012596 2034.0315835183335 1739.8543109541272 2053.9385980789157 1912.0973017841584 2164.7581627725053 0.9123260412351586 0.7845606252697634 1.016443149431576 0.6900701273335417 0.822888233630586 0.9396114626094102 0.8037176350109315 0.9488074157199814 0.8832844863073515 1.0 11.079990147093662 -8.631103896068694 0.7114492249913912 0.9987169100647021 0.8503596310822534 0.18779173185745546 0.08858779662755831 1.412025675235934 1.5737142649961453 0.08548163787940054 0.03270451114723528 2.3382777866263573e-09 8.631103896068694 -0.14835727898244866 NDQCYDDIR ddPTM_A459_Selumetinib_30min_R1 1 NDQCYDDIR 9 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 156.83 0.011732 11768000.0 1613.3 1597.7 1562.9 1828.9 2093.9 1524.2 1692.8 1456.0 979.88 1108.7 False True 1650.88675106466 1410.6405412494205 1350.6667643951819 1509.516947704919 1904.50711470807 1508.8679318628713 1565.1107331189003 1417.3821502454628 1662.7847923963977 1251.0124446525285 1.3196405504368884 1.1275991276339614 1.0796589355834367 1.2066362362399925 1.5223726373377933 1.2061174437652877 1.2510752709207567 1.132988050042255 1.32915128023226 1.0 10.288880425683956 -10.805832160286942 3.3877276908186458 0.9991233254046779 1.2368284206733002 0.26344963441682057 0.12099201322473907 58844715.89011473 75851868.83758876 514905.0720718125 0.03076813184362931 1.5637518615878772e-11 10.805832160286942 0.23770509526862238 NDQDTWDYTNPNLSGQGDPGSNPNKR ddPTM_A459_Selumetinib_30min_R2 2 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 ; 148.17 1.0807e-10 13325100.0 52286.0 46555.0 56525.0 54881.0 57533.0 44521.0 38391.0 45863.0 39125.0 54122.0 False True 49380.15343744176 50125.618802081175 52888.24303976666 47406.11312499442 50305.19018845418 50653.36362860087 40176.25757032332 45996.45373697162 46951.0932438385 52559.357234156305 0.9395121256420446 0.9536954300785563 1.0062574168124838 0.901953821729521 0.9571119746449785 0.9637363600725923 0.7643978101051494 0.8751334901614872 0.8932965643903801 1.0 15.681660012120549 NDQEPPPEALDFS(ph)DDEK ddPTM_A459_Selumetinib_30min_R2 1 NDQEPPPEALDFSDDEK 17 0 Q96HR8-2;Q96HR8 Q96HR8-2 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 1 NDQEPPPEALDFS(1)DDEK 111.63 0.0025692 0.0 12392.0 10743.0 9068.9 9656.5 10327.0 8812.2 15100.0 14607.0 12708.0 9089.9 True False 11703.302249106418 11566.95355581051 8485.416847471735 8341.26804160836 9029.629935448635 10026.000560813023 15802.179920082366 14649.503951680976 15249.955091187216 8827.450968603478 1.3257850188838722 1.310339031839497 0.9612533536183602 0.9449237465351753 1.0229034369677321 1.1357752760646778 1.7901181186149715 1.6595395436105786 1.7275604413353984 1.0 13.107781187330728 -7.222736046291437 10.918012243924286 1.5991837091766508 1.1062792955497611 0.4318283151520744 0.2367084521652016 0.7442977548170726 208.58581258168675 0.08952626776725033 0.06914849650369255 5.987754057373425e-08 7.222736046291437 -0.49290441362688964 NDQEPPPEALDFS(ph)DDEKEK ddPTM_A459_Selumetinib_30min_R1 3 NDQEPPPEALDFSDDEKEK 19 1 Q96HR8-2;Q96HR8 Q96HR8-2 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 1 NDQEPPPEALDFS(1)DDEKEK;NDQEPPPEALDFS(1)DDEKEK;NDQEPPPEALDFS(1)DDEKEK 123.85 0.00022533 109744000.0 20626.03 25499.190000000002 18701.14 20456.52 13852.310000000001 21872.9 19642.34 20679.23 15025.990000000002 22849.69 True False 21106.576367732127 22513.732980548193 16161.627906008904 16884.17279843875 12599.371006323972 21652.87848500421 18160.702479661344 20130.749644794287 25498.0075751116 25782.670286328517 0.8186342273059307 0.8732118407644647 0.62684073164364 0.6548651714865907 0.4886759542903086 0.8398229603271867 0.7043763224669252 0.7807860637099637 0.9889591455013927 1.0 14.654114069522942 -8.188505531443553 2.662407083379607 1.008366176248898 0.7117062391763272 0.5137761363901387 0.10700115007544397 0.24346491025158687 3.1079451565719953 0.10087535360899269 0.030419028639864218 6.478798434172026e-09 8.188505531443553 -0.29665993707257077 NDQEPPPEALDFS(ph)DDEKEK ddPTM_A459_Selumetinib_30min_R2 4 NDQEPPPEALDFSDDEKEK 19 1 Q96HR8-2;Q96HR8 Q96HR8-2 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 1 NDQEPPPEALDFS(1)DDEKEK;NDQEPPPEALDFS(1)DDEKEK;NDQEPPPEALDFS(1)DDEKEK;NDQEPPPEALDFS(1)DDEKEK 97.152 0.00086369 264887500.0 295243.0 246791.0 232962.0 208553.0 192473.0 153892.0 241869.0 199017.0 121595.0 208654.0 True False 278834.5760113722 265719.0761418623 217973.4785498479 180147.7216260085 168292.82100954824 175089.2261075145 253116.3877543315 199596.10652096217 145917.3976481673 202629.61687180217 1.3760800632998418 1.3113535930434839 1.075723686966024 0.8890493127664685 0.8305440419206941 0.8640850671809163 1.2491579052556312 0.9850292844764188 0.720118805438422 1.0 17.628485532047222 -5.346333454892238 2.5087328696208813 0.9399495836525186 1.3660992166841184 0.6052601667263895 0.1310657014323063 0.2121785322747161 2.5475707683092916 0.038674748313059316 0.11124956191555575 4.504706966010165e-06 5.346333454892238 0.4261496330315998 NDQEPPPEALDFS(ph)DDEKEKEAK ddPTM_A459_Selumetinib_30min_R1 1 NDQEPPPEALDFSDDEKEKEAK 22 2 Q96HR8-2;Q96HR8 Q96HR8-2 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 1 NDQEPPPEALDFS(1)DDEKEKEAK 44.729 0.035615 4484100.0 926.51 842.52 2373.4 2278.2 1257.2 1453.9 722.17 690.97 584.73 579.91 True False 948.0958803253695 743.8773667230782 2051.105316153002 1880.355137110474 1143.4864819766874 1439.2750860355786 667.6961354775977 672.6432310131228 992.2441030105175 654.3470973017478 1.4489189059368004 1.136823819942834 3.134583044092192 2.8736356359862643 1.7475228157837708 2.1995590596650367 1.0204005461793837 1.0279608999364718 1.5163880257161908 1.0 9.353912303663193 -7.260078050371554 24.92356429367835 1.143517412943949 2.11434980335095 0.3920828473209359 0.5784211060266922 136.2755477631079 2495000.38011443 0.2510941864122681 0.1836647033049439 5.4944212055267974e-08 7.260078050371554 0.9708323904070011 NDQWHWDNIR ddPTM_A459_Selumetinib_30min_R1 2 NDQWHWDNIR 10 0 E9PF63;O75116;D6REE7;C9JFJ0 E9PF63 ROCK2 Rho-associated protein kinase 2 0 ; 119.45 0.007582699999999999 5300800.0 5454.4 5934.3 7221.6 7095.8 5252.5 6045.6 5717.3 5476.2 3587.8999999999996 5525.4 False True 5581.476907585126 5239.509397218777 6240.946385409334 5856.651734662669 4777.412302404192 5984.786752965604 5286.03945797536 5330.953386795467 6088.404250152095 6234.638911953715 0.8952365945177231 0.8403869849099088 1.0010116822392914 0.9393730442726476 0.7662692851777554 0.9599251596577522 0.847850137373698 0.8550540716278523 0.9765448065450522 1.0 12.606090291386014 -8.384627361782043 5.048922774173575 0.9979495017342311 0.8892123335955506 0.28567117798906994 0.06366233583955361 0.28934322526815753 9.995513872079687 0.061002659275864304 0.015910234928710007 4.124512633686364e-09 8.384627361782043 -0.1087371681386805 NDREYDS(ph)GDTDEIIAMK ddPTM_A459_Selumetinib_30min_R1 1 NDREYDSGDTDEIIAMK 17 1 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 NDREYDS(0.995)GDT(0.005)DEIIAMK 101.6 0.0021556 8483600.0 2809.7 3776.1 2769.6 2875.2 2883.5 2625.9 2855.8 3042.4 1242.9 2898.5 True False 2875.1605432755077 3333.9924565387355 2393.50353232382 2373.10029418841 2622.6879341232725 2599.485830126436 2640.384706782228 2961.705668892029 2109.110522175656 3270.550708780874 0.8791059363660649 1.0193978792585392 0.7318350166220229 0.7255965448928946 0.8019101881165762 0.7948159382293806 0.8073211339280699 0.9055678791160007 0.6448793215506649 1.0 11.675317867765381 -5.262928088582302 24.999347892796198 0.7953924907127169 0.9492519092905831 0.26595914087447625 0.09777224638872023 147.15531199622228 2471176.4753038585 0.023753920871086538 0.05408901034470838 5.45848236337936e-06 5.262928088582302 0.15385941857786622 NDRGDQVPNR ddPTM_A459_Selumetinib_30min_R1 1 NDRGDQVPNR 10 1 F5H1H2;F5H2E6;A0A0C4DGG8;Q8IX12-2;Q8IX12;F5H3E1 F5H1H2 CCAR1 Cell division cycle and apoptosis regulator protein 1 0 97.965 0.023952 0.0 78.559 0.0 185.42 0.0 0.0 0.0 0.0 142.74 0.0 0.0 False True 80.38927185079571 0.0 160.24098243915455 0.0 0.0 0.0 0.0 138.95407151513555 0.0 0.0 0.0 NDS(ph)GEENVPLDLTR ddPTM_A459_Selumetinib_30min_R1 2 NDSGEENVPLDLTR 14 0 Q6R327-3;Q6R327;Q6R327-4 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 NDS(1)GEENVPLDLTR;NDS(1)GEENVPLDLTR 191.41 0.00010635 55872000.0 2165.88 3241.0299999999997 2439.35 2176.96 2173.06 2181.32 2695.17 2568.8 1306.74 2160.81 True False 2216.340789931152 2861.5687008860286 2108.09966839042 1796.7948026003064 1976.5071066849046 2159.3779012800937 2491.8711570061846 2500.6670793616368 2217.4423394865385 2438.1710115717783 0.9090177757885726 1.1736538115270696 0.8646233830134105 0.736943714806122 0.8106515487651295 0.8856548170868624 1.0220247657689066 1.025632356177334 0.909469569182128 1.0 11.251583603767891 -10.245857604627359 12.556515715478488 1.0 0.9274176359938466 0.03466197279485406 0.11640080214235467 0.0 0.0 0.12375193524188653 0.030014252963346758 5.677307210034288e-11 10.245857604627359 -0.07258236400615337 NDS(ph)GEENVPLDLTR ddPTM_A459_Selumetinib_30min_R2 2 NDSGEENVPLDLTR 14 0 Q6R327-3;Q6R327;Q6R327-4 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 NDS(1)GEENVPLDLTR;NDS(0.998)GEENVPLDLT(0.002)R 200.94 6.4459e-05 36246000.0 75867.0 61970.0 81398.0 80417.0 73014.0 69642.0 72505.0 75627.0 56646.0 73328.0 True False 71650.61585966396 66722.89973504397 76160.94129944136 69464.06587293728 63841.32856655826 79234.5533528677 75876.62616593188 75847.06204927621 67976.78282148174 71210.83011097561 1.0061758267387555 0.9369768563442161 1.0695134599716285 0.9754705255462384 0.8965115062844703 1.1126756032669167 1.0655208771992273 1.0651057139914737 0.9545848955214551 1.0 16.11980904994345 -6.770019117814452 24.999996832326623 1.0452679709169028 0.9797725159237042 0.22471780295232424 0.05757871191060921 289.5383895834491 843663.9199691582 0.020318732515368285 0.018196891707060257 1.698168896751491e-07 6.770019117814452 -0.06549545499319864 NDS(ph)LPVLR ddPTM_A459_Selumetinib_30min_R2 1 NDSLPVLR 8 0 Q9GZY8-5 Q9GZY8-5 MFF Mitochondrial fission factor 1 NDS(1)LPVLR 88.155 0.031466 2395500.0 20782.0 11398.0 17498.0 20192.0 12729.0 13127.0 24177.0 17809.0 12366.0 16338.0 True False 19627.019636937493 12272.189949653553 16372.197730381908 17441.814766857147 11129.869221296172 14935.125094958417 25301.278405816633 17860.821241561338 14839.545534908799 15866.279488778058 1.237027221839836 0.7734762241099723 1.0318863815528825 1.0993008650322489 0.7014794633592667 0.9413123666151079 1.5946572996972468 1.1257094805492356 0.9352882977641072 1.0 13.953676247334085 NDS(ph)PTQIPVSSDVCR ddPTM_A459_Selumetinib_30min_R1 3 NDSPTQIPVSSDVCR 15 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 NDS(0.522)PT(0.478)QIPVSSDVCR;NDS(0.797)PT(0.203)QIPVSSDVCR;NDS(0.774)PT(0.226)QIPVSSDVCR 316.33 1.9801999999999993e-95 99414000.0 8076.799999999999 8899.6 9455.8 10152.7 7873.299999999999 6844.2 8623.3 7932.9 4593.4 6766.1 True False 8264.97372528299 7857.630694688211 8171.754296991471 8379.721534782506 7161.1614051440165 6775.353562036391 7972.837538341335 7722.493722309228 7794.664311337724 7634.594842395122 1.0825687408305356 1.0292138426330844 1.0703586065384225 1.0975987210545441 0.9379884005602869 0.8874542397996892 1.0443039483991923 1.0115132343927409 1.0209663344613562 1.0 12.898335881844414 -6.255641775092411 24.97434233027421 0.9824974944836824 1.0670565851829985 0.469973016857946 0.04480942895198935 486.3624871937606 2095100.4862469733 0.014601962219051851 0.018326496138124437 5.550833810053547e-07 6.255641775092411 0.08455909069931611 NDS(ph)PTQIPVSSDVCR ddPTM_A459_Selumetinib_30min_R2 2 NDSPTQIPVSSDVCR 15 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 NDS(0.774)PT(0.226)QIPVSSDVCR;NDS(0.653)PT(0.347)QIPVSSDVCR 263.47 1.0833e-36 58234000.0 52404.0 49310.0 59715.0 63738.0 71402.0 46249.0 51353.0 49180.0 37260.0 56147.0 True False 49491.595469833184 53091.91844335995 55873.00191277608 55056.77444581718 62431.842418020984 52619.379943378706 53741.01625403906 49323.10565781273 44713.04113138461 54525.890222574446 0.9076714798751329 0.9737010845057086 1.0247059091507307 1.0097363696599113 1.1449944634223206 0.9650347702455957 0.9856054808948275 0.904581391637551 0.8200332163100167 1.0 15.734653798917247 -7.685535249809358 2.9073239908708133 0.8943473169273731 1.0088391374873573 0.2694221102383747 0.0699116904700086 0.3205638287297952 5.432566588202158 0.041090317333256535 0.020171849468080132 2.0628362289989562e-08 7.685535249809358 0.11449182055998419 NDS(ph)WGSFDLR ddPTM_A459_Selumetinib_30min_R1 2 NDSWGSFDLR 10 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 NDS(0.998)WGS(0.002)FDLR;NDS(0.989)WGS(0.011)FDLR 134.4 0.0021081 155195000.0 8271.9 9715.2 10758.2 11760.1 8415.0 8623.7 8374.6 7654.8 4784.1 7153.7 True False 8464.619175684475 8577.739867526057 9297.295530562584 9706.41929941747 7653.864735788917 8536.953407693114 7742.897179570861 7451.769837705337 8118.268283160805 8071.947077938841 1.0486465153889366 1.0626605681012926 1.1518033308187439 1.20248797541621 0.9482055149627318 1.0576077029822415 0.9592353746635314 0.9231688173565348 1.0057385417390263 1.0 12.978701000403994 -6.276444176123925 24.99402612641272 0.9810939833823337 1.1150899368148386 0.6073235512032904 0.052805096717755774 586.2312304590488 976504.161688429 0.01743510895947955 0.01985067800976295 5.29122005771095e-07 6.276444176123925 0.13399595343250492 NDS(ph)WGSFDLR ddPTM_A459_Selumetinib_30min_R2 4 NDSWGSFDLR 10 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 NDS(0.999)WGS(0.001)FDLR;NDS(0.988)WGS(0.012)FDLR;NDS(0.993)WGS(0.007)FDLR;NDS(0.981)WGS(0.019)FDLR 167.22 0.00030242 36586600.0 148216.0 147685.0 156278.0 160182.0 162531.0 113483.0 126441.0 132207.0 99535.0 159523.0 True False 139978.74807565822 159011.9646178788 146223.24362262108 138364.9352706373 142112.40273442434 129114.25315389398 132320.75703808828 132591.700481953 119444.78124026762 154917.15649946974 0.9035716329852552 1.026432244245479 0.9438802449431841 0.8931543697105679 0.9173445081591771 0.8334406341516856 0.8541388186307254 0.8558877756215907 0.7710235840836419 1.0 17.241137400527364 -6.077382669556808 1.280766414264516 0.8555275404254504 0.9678831827742858 0.27051888137909463 0.062404673407414464 0.5013589551191941 1.6709799264583405 0.022394082789639686 0.038580398011264665 8.367916356349291e-07 6.077382669556808 0.11235564234883533 NDSGEENVPLDLT(ph)REPSDNLR ddPTM_A459_Selumetinib_30min_R1 1 NDSGEENVPLDLTREPSDNLR 21 1 Q6R327-3;Q6R327;Q6R327-4 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 NDS(0.07)GEENVPLDLT(0.863)REPS(0.067)DNLR 72.793 0.0060021 3897400.0 399.04 361.03 839.41 908.27 571.73 585.66 450.72 361.24 378.43 394.15 True False 408.3368556033238 318.7604397617063 725.4227325490823 749.6576948394913 520.0171224471299 579.7687921367339 416.7218275232464 351.6587417271093 642.1680705663637 444.7429918461206 0.9181411806138292 0.7167295395449339 1.6311054830518292 1.685597544162922 1.1692531011867047 1.3036041101628684 0.936994702925933 0.7907010299754917 1.4439082399044332 1.0 8.796828061802275 -7.255970197685837 24.170062620835587 1.0254594141191335 1.2489081178798138 0.08327298604093836 0.3126363695673641 761.0833916766226 3363483.9950615093 0.13199534114986322 0.09914343523961232 5.5466377399155534e-08 7.255970197685837 0.22344870376068027 NDSPT(ph)QIPVSSDVCR ddPTM_A459_Selumetinib_30min_R1 1 NDSPTQIPVSSDVCR 15 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 NDS(0.011)PT(0.989)QIPVSSDVCR 232.01 1.1601e-13 46664000.0 2534.0 2829.8 3002.7 3694.1 2865.9 2902.4 2890.4 2927.6 1567.4 2503.3 True False 2593.0372696943223 2498.48570046167 2594.9498326504677 3048.9947818452288 2606.679851015741 2873.204491168352 2672.374800925609 2849.9505378149825 2659.763321633379 2824.6229392068853 0.918011828659301 0.884537778753298 0.9186889324700781 1.0794342634282166 0.9228417056428991 1.0171993051841135 0.9460996594738321 1.008966718444625 0.9416348230819803 1.0 11.463842578723328 -5.5465077288871365 24.99962560295482 0.9862215570139728 0.9013593867996522 0.42929626402290355 0.043046993809663564 185.4016100157724 196155.2923269979 0.010744754588238306 0.018611629009317024 2.8411376224540534e-06 5.5465077288871365 -0.08486217021432063 NDSPT(ph)QIPVSSDVCR ddPTM_A459_Selumetinib_30min_R2 2 NDSPTQIPVSSDVCR 15 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 NDS(0.236)PT(0.764)QIPVSSDVCR;NDS(0.09)PT(0.91)QIPVSSDVCR 284.23 3.278e-55 136292000.0 96976.0 66480.0 91014.0 101697.0 95585.0 65059.0 72555.0 77002.0 54162.0 75925.0 True False 91586.46214568621 71578.80223310848 85158.25832855051 87845.69316288987 83576.75775925792 74020.28670319954 75928.95126500497 77226.06307163266 64995.91341272287 73732.84797315914 1.2421392183172728 0.9707858057939822 1.1549568566719484 1.1914051278050215 1.1335077927504205 1.0038983809515272 1.0297845987536691 1.047376646833785 0.8815055324647604 1.0 16.170019862511317 -6.769276358092129 6.623912785353064 0.9972634454373766 1.1333963076451519 0.47331669276786215 0.07687078444018584 0.1446833346403568 28.241381335239815 0.026367176205109293 0.02441829604942797 1.7010757047655345e-07 6.769276358092129 0.13613286220777532 NDSVIVADQTPT(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 NDSVIVADQTPTPTR 15 0 B8ZZU6;E9PBF9;P15336-5;P15336;E9PEK8;H7C2N6;P15336-3;P15336-7 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 NDSVIVADQTPT(0.997)PT(0.003)R 154.47 0.00043873 7201700.0 1977.5 1965.7 2448.7 2376.7 1878.3 1532.3 1758.6 1812.1 1171.3 1662.5 True False 2023.5719024548223 1735.5549301708625 2116.1799897462947 1961.6539611844712 1708.4080966407985 1516.8864532170837 1625.947386143017 1764.0372214696447 1987.610551632752 1875.8980691213394 1.078721672442817 0.9251861594930832 1.1280890068496643 1.0457145798456413 0.910714779636725 0.8086188040737123 0.8667567886055781 0.940369442512359 1.0595514672946693 1.0 10.873365722766783 -4.750278254020618 24.546837059019484 0.9611020789176009 1.0787219947249131 0.12215641258794241 0.09091760244046572 958.3270844523314 2107490.5014550113 0.025205283314717192 0.37009674145664834 1.777140425005189e-05 4.750278254020618 0.11761991580731224 NDSVIVADQTPT(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 NDSVIVADQTPTPTR 15 0 B8ZZU6;E9PBF9;P15336-5;P15336;E9PEK8;H7C2N6;P15336-3;P15336-7 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 NDSVIVADQT(0.005)PT(0.989)PT(0.006)R;NDSVIVADQT(0.119)PT(0.881)PTR 194.67 7.2785e-05 21412900.0 68097.0 65137.0 67603.0 76367.0 75951.0 56199.0 62320.0 66970.0 50067.0 65121.0 True False 64312.4413538896 70132.79845153392 63253.49658058111 65965.68285957714 66409.35636944511 63939.90212627166 65218.003484737244 67164.87161251971 60081.798988862916 63240.787525322325 1.0169456116930575 1.1089804728230488 1.000200962950591 1.043087624947171 1.0501032477316015 1.0110548054239428 1.0312648851601227 1.0620498928104924 0.9500482416479316 1.0 15.948567712960516 -8.259607096929571 24.99995254278242 0.97502411858402 1.0405251507672126 0.4156542081975091 0.031034869523477823 147.21938471203487 2008746.1431113216 0.02243765901036897 0.0075075567878471845 5.5003826446257265e-09 8.259607096929571 0.06550103218319259 NDSYTLHK ddPTM_A459_Selumetinib_30min_R1 1 NDSYTLHK 8 0 P62195-2;P62195;J3QSA9;J3QQM1;J3QRW1;J3QLH6;J3KRP2;J3QSE0 P62195-2 PSMC5 26S protease regulatory subunit 8 0 111.46 0.013999 0.0 2623.5 3208.8 2414.1 3143.2 2552.5 2708.7 2859.3 2563.7 1549.3 2094.6 False True 2684.622445557639 2833.1122042693496 2086.278479702099 2594.2991251714693 2321.626825680476 2681.4529373028217 2643.6206989643642 2495.7023479287714 2629.0489436050734 2363.462313131764 1.1358854468046558 1.1987126634210066 0.8827212806019421 1.0976689201926937 0.9822990672544921 1.1345444022543758 1.1185372765522839 1.0559518271403192 1.1123718491289956 1.0 11.206686144877416 NDSYTLHK ddPTM_A459_Selumetinib_30min_R2 2 NDSYTLHK 8 0 P62195-2;P62195;J3QSA9;J3QQM1;J3QRW1;J3QLH6;J3KRP2;J3QSE0 P62195-2 PSMC5 26S protease regulatory subunit 8 0 ; 112.11 0.015896 3372100.0 64220.0 60195.0 64686.0 78548.0 72527.0 48453.0 53982.0 50168.0 47193.0 69832.0 False True 60650.9094930289 64811.76294256853 60524.173184791616 67849.62689714215 63415.509860393366 55126.96093745874 56492.26996330371 50313.98057424051 56632.91868259348 67815.76871467441 0.8943481824737447 0.9557034325638212 0.892479350037877 1.0004992671042363 0.9351145177931325 0.8128929595917124 0.8330255784755198 0.7419215549399685 0.835099561001347 1.0 16.04933315145641 -6.755738642973857 24.65271181753596 0.827735374908224 0.9379509305498938 0.29734835381960045 0.06748776537982411 118.39546591155347 511998.053355141 0.02145835233273925 0.020888694788369376 1.754936299157782e-07 6.755738642973857 0.11021555564166974 NDVVEALTGS(ph)AASR ddPTM_A459_Selumetinib_30min_R2 1 NDVVEALTGSAASR 14 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 NDVVEALT(0.007)GS(0.988)AAS(0.004)R 99.371 0.0097397 2027200.0 18200.0 13894.0 18020.0 17162.0 16374.0 18342.0 13628.0 16645.0 11935.0 16798.0 True False 17188.51686037257 14959.625123748601 16860.612818692538 14824.505993898692 14316.951734582739 20868.444007901835 14261.7290033697 16693.4341942719 14322.333491762618 16312.998093554525 1.0536700097552254 0.9170371404419732 1.0335692263308964 0.9087542283080414 0.8776407409892085 1.2792525253924492 0.8742555428241418 1.0233210412050309 0.8779706470646592 1.0 13.993734332488998 NEAIQAAHDAVAQEGQCR ddPTM_A459_Selumetinib_30min_R1 2 NEAIQAAHDAVAQEGQCR 18 0 D6R974;D6R956;P09936 D6R974 UCHL1 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase isozyme L1 0 ; 102.84 0.0030948 35994000.0 10748.099999999999 11874.3 10590.1 11161.9 10058.2 9772.0 9889.599999999999 10400.0 5897.799999999999 9748.1 False True 10998.509817838027 10484.051435787691 9152.022587255375 9212.683699812742 9148.43758591944 9673.702552266099 9143.61950983736 10124.158216039013 10008.135841731106 10999.363589534882 0.9999223799004456 0.95315073008065 0.8320501920641007 0.8375651577313037 0.8317242639950128 0.8794783874105174 0.8312862317358859 0.9204312716484284 0.9098831728094834 1.0 13.425132433046391 -10.134268186853609 8.239018591448112 0.9999998939699934 0.8844753410821715 0.2659262910097622 0.055288699809692005 0.0 0.0 0.05778988629371735 0.014016106193025353 7.34060428931057e-11 10.134268186853609 -0.11552455288782193 NEAIQAAHDAVAQEGQCR ddPTM_A459_Selumetinib_30min_R2 3 NEAIQAAHDAVAQEGQCR 18 0 D6R974;D6R956;P09936 D6R974 UCHL1 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase isozyme L1 0 ;; 127.91 0.00099033 43510000.0 100976.5 101796.6 100661.0 108427.0 109402.0 74096.6 90925.9 91691.4 63818.9 96844.9 False True 95364.6303709566 109604.07189234094 94184.58085141006 93659.05555299215 95657.94269371069 84302.73406803516 95154.13451625271 91958.20679367156 76584.46324905321 94048.7361037314 1.0139916209588806 1.1653965426122552 1.00144440800915 0.9958566104459985 1.0171103478541637 0.8963728547617392 1.011753463771189 0.9777718510990506 0.8143061397931398 1.0 16.52112093542837 -5.894033094196598 0.9029228136990289 0.9418284628439278 1.0926834800475322 0.3628506311337921 0.06800939788442234 0.7282801123357057 1.1563337322859077 0.02926411610995266 0.07723580545989406 1.2763415450670607e-06 5.894033094196598 0.1508550172036044 NEDEEEEEEEKDEAEDLLGR ddPTM_A459_Selumetinib_30min_R1 1 NEDEEEEEEEKDEAEDLLGR 20 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 152.66 2.3191e-05 18647000.0 1253.6 1295.4 1285.1 1523.3 976.42 1570.4 1298.9 1298.2 763.11 1009.8 False True 1282.8064409190226 1143.7339657848781 1110.590478549011 1257.284250882444 888.1029834009524 1554.6032018091164 1200.922927249611 1263.7675188521018 1294.9419346507896 1139.4176662849488 1.1258439103385067 1.0037881626971807 0.9747000695276841 1.1034445823380965 0.7794358554195465 1.3643839724531153 1.0539795570883141 1.1091345660565308 1.1364945208133597 1.0 10.15408096465461 -6.759676515147117 24.99998858337459 1.13469321418527 1.0024206330376175 0.22868962793775127 0.12409797546146392 73.69690686446036 1045135.0687511195 0.04024957986680154 0.03826881515154563 1.7390957143184893e-07 6.759676515147117 -0.1322725811476524 NEDEEEEEEEKDEAEDLLGR ddPTM_A459_Selumetinib_30min_R2 2 NEDEEEEEEEKDEAEDLLGR 20 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 ; 112.91 0.00089035 8790400.0 23707.8 21534.0 21189.8 18784.2 20289.0 18813.7 20529.8 22987.0 13233.4 19746.2 False True 22390.21538584288 23185.588557276697 19826.471337709827 16225.759555447594 17740.114434038667 21405.11640123557 21484.476379026943 23053.88836429729 15880.449772089773 19176.075899210995 1.1676119506162432 1.2090893193758518 1.033917024625752 0.8461459811032145 0.9251170326650923 1.116240700847262 1.120379189775262 1.2022213765458578 0.8281386585846366 1.0 14.22701990387017 -5.297485050246923 6.410342417430284 1.0147126818384107 1.1885428688997763 0.28415405030710783 0.11367891360061969 0.25399631927231653 32.87338115052688 0.031836753385703125 0.06921206792706777 5.04097971408089e-06 5.297485050246923 0.17383018706136566 NEDSGS(ph)ETAYLENR ddPTM_A459_Selumetinib_30min_R2 1 NEDSGSETAYLENR 14 0 J3QT39;Q49A88;Q49A88-5 J3QT39 CCDC14 Coiled-coil domain-containing protein 14 1 NEDS(0.099)GS(0.894)ET(0.007)AYLENR 193.3 0.00011502 10906000.0 16067.0 13958.0 18310.0 19542.0 15581.0 13443.0 15425.0 15532.0 9384.0 14479.0 True False 15174.06046129703 15028.53371795616 17131.954534420653 16880.345888169693 13623.575484092686 15294.65122659604 16142.293064057649 15577.195548538975 11261.06221086724 14060.953649040126 1.0791629671813112 1.0688132606839285 1.218406301736879 1.2005121636484475 0.9688941322285564 1.0877392535633692 1.1480226353750627 1.1078335038535851 0.8008747124798309 1.0 13.779406824463734 -8.241650860912785 23.409019309639802 0.9004374095043826 1.1110180460498016 0.522015726756768 0.08017696836203456 241.9023269821962 286162.40038676304 0.055065685059229486 0.020730366440762604 5.7325669972492705e-09 8.241650860912785 0.21058063654541903 NEEDEGHS(ph)NS(ph)SPRHSEAATAQR ddPTM_A459_Selumetinib_30min_R2 1 NEEDEGHSNSSPRHSEAATAQR 22 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 2 NEEDEGHS(0.76)NS(0.58)S(0.293)PRHS(0.124)EAAT(0.243)AQR 49.559 0.044411 3377100.0 7217.1 6049.8 8194.3 9440.4 10662.0 8344.8 5185.8 7901.9 7530.9 10045.0 True False 6816.002474340377 6513.800206826999 7667.08765927926 8154.601234401655 9322.544240510631 9494.220453447788 5426.949975467756 7924.893220770032 9037.290430927114 9754.974749955663 0.6987206680746515 0.6677413703050953 0.7859669405411949 0.8359428336232975 0.955670771013836 0.973269608257155 0.5563263990501279 0.8123950521559321 0.9264288901381512 1.0 13.251922423189788 -1.5228804639793567 0.05878722151118373 1.2132934527415256 5.6512201937791215e-09 0.26735081110151904 0.11937197238463727 601.0338994700849 2.6534554563115056 11.31725305760932 62.85081555051774 0.029999881276712694 1.5228804639793567 -1.2132934470903054 NEEDEGHS(ph)NSSPR ddPTM_A459_Selumetinib_30min_R2 1 NEEDEGHSNSSPR 13 0 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 NEEDEGHS(0.599)NS(0.136)S(0.265)PR 103.66 0.0083102 7590200.0 32801.0 23148.0 25924.0 31879.0 31948.0 29549.0 35952.0 41776.0 27822.0 33928.0 True False 30978.051732806627 24923.37716744872 24256.07806391706 27537.025205657636 27934.40662125622 33619.106530884914 37623.83923753652 41897.561243610915 33387.17741163129 32948.41048446945 0.9401986705066828 0.7564364046999048 0.736183558091532 0.8357618713848874 0.8478225872056369 1.020355945447857 1.1419014964400447 1.271611001185011 1.013316785869493 1.0 15.007921247165568 -6.856581009329073 2.3686035996502426 1.128199552805284 0.8088266336743656 0.7023134008712981 0.08765190922888405 0.15008865663877602 1.7189554287667597 0.03449094395872563 0.030018926555060256 1.391294251306968e-07 6.856581009329073 -0.31937291913091836 NEEDEGHSNS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 5 NEEDEGHSNSSPR 13 0 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 NEEDEGHS(0.062)NS(0.726)S(0.212)PR;NEEDEGHS(0.002)NS(0.499)S(0.499)PR;NEEDEGHS(0.009)NS(0.897)S(0.094)PR;NEEDEGHS(0.095)NS(0.608)S(0.298)PR;NEEDEGHSNS(0.751)S(0.249)PR 130.47 0.0013967 41528700.0 9108.289999999999 14564.42 8052.98 7147.310000000001 7300.299999999999 10294.85 8841.839999999998 10952.199999999999 11214.69 11735.09 True False 9320.495435352841 12859.210935584832 6959.429547852784 5899.166480125126 6639.989153972645 10191.293155975918 8174.8928901937725 10661.712078240622 19030.509841449933 13241.403110956478 0.7038903171553385 0.9711365803027773 0.5255809742771343 0.4455091677742153 0.501456612893119 0.7696535684759288 0.6173736137848965 0.805179933644546 1.4371973787055325 1.0 13.692768383414037 -8.083761589806967 4.872460510787108 1.2103674273456455 0.6500222779645309 0.6288384674179198 0.17274329642943193 0.1467572048075232 5.930973248430151 0.12713559648476982 0.046283850088503144 8.245906578744838e-09 8.083761589806967 -0.5603451493811146 NEEDEGHSNS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 4 NEEDEGHSNSSPR 13 0 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 NEEDEGHS(0.001)NS(0.629)S(0.37)PR;NEEDEGHS(0.052)NS(0.621)S(0.327)PR;NEEDEGHSNS(0.925)S(0.075)PR;NEEDEGHS(0.157)NS(0.421)S(0.421)PR 232.78 2.4726999999999997e-13 1632042400.0 49696.3 36422.399999999994 33864.9 39166.0 41023.1 37938.4 67451.0 94197.5 44925.9 60835.9 True False 46934.37859605127 39215.88096352532 31686.069203315266 33831.523234881475 35869.411426832856 43164.07022949422 70587.60515162085 94471.5991297644 53912.33533452686 59079.40949634921 0.7944287019143541 0.6637825478934188 0.5363301609382757 0.5726449117094186 0.6071389631788617 0.730611063947102 1.1947919885012186 1.5990613300832373 0.9125401860669977 1.0 15.850367785866334 -7.223548218872247 3.911981028819743 1.232069542222277 0.6323653938269789 0.6645998971553448 0.18235574394480783 0.12260640219014822 4.097681923196939 0.07322073581443225 0.053287453206708135 5.976566843447587e-08 7.223548218872247 -0.5997041483952981 NEEDEGHSNSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 NEEDEGHSNSSPR 13 0 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 NEEDEGHS(0.036)NS(0.083)S(0.881)PR;NEEDEGHS(0.02)NS(0.283)S(0.697)PR 146.84 0.00058932 6163200.0 503.59 859.0 661.96 644.1 413.26 650.99 287.82 642.74 1188.57 1076.72 True False 515.3226671844371 758.4278806617338 572.0694678860041 531.6200262544361 375.8807059669791 644.4416316516276 266.1095056747885 625.692447286242 2016.9164802818575 1214.927500140949 0.424159192317774 0.6242577277851932 0.4708671651762231 0.43757345701102374 0.309385297413526 0.530436286590651 0.21903323913889183 0.5150039382709278 1.6601126240437116 1.0 10.24665450935086 -8.194468787897433 7.1402971924589025 1.325925734274698 0.4367979514420936 0.7924328802289429 0.1820341069875044 0.09191246923733216 8.447250970491496 0.11670423240195574 0.04326713598222347 6.390446628934291e-09 8.194468787897433 -0.8891277828326043 NEEDEGHSNSS(ph)PRHS(ph)EAATAQR ddPTM_A459_Selumetinib_30min_R2 1 NEEDEGHSNSSPRHSEAATAQR 22 1 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 2 NEEDEGHS(0.007)NS(0.452)S(0.543)PRHS(0.894)EAAT(0.104)AQR 76.0 0.0034591 1413700.0 2867.8 1046.8 2732.6 2790.6 2955.4 3784.1 2773.0 3547.4 2516.7 3872.8 True False 2708.4191567129924 1127.0861940074872 2556.787491029924 2410.51546594649 2584.116230388777 4305.325426360338 2901.949994595257 3557.7223466963173 3020.1103224733138 3760.9822012571685 0.7201361271552043 0.29967868330531866 0.6798190882624429 0.6409271134388077 0.6870854718549305 1.1447343262941296 0.7715936527498678 0.945955645710605 0.803011064892515 1.0 11.876893763542625 -6.56622280902422 7.599382758702553 0.9202867325929968 0.5825865276828321 0.5732471649660673 0.14323148274677533 0.16366299311849097 24.038583298437484 0.046300024733153464 0.04645200746334933 2.715045993129665e-07 6.56622280902422 -0.3377002049101646 NEEDEGHSNSSPR ddPTM_A459_Selumetinib_30min_R2 2 NEEDEGHSNSSPR 13 0 D6RAF8;Q14103-3;Q14103;D6RD83 D6RAF8 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 ; 191.01 0.00017879 18202700.0 80193.0 56916.0 55763.0 91127.0 87474.0 71705.0 104446.0 125909.0 98950.0 117979.0 False True 75736.19409801408 61281.274186215254 52175.26929016378 78715.34539715703 76484.73409251799 81581.71287681835 109302.94595582272 126275.37434464291 118742.76489400209 114572.63972374477 0.6610321127332639 0.5348683100430908 0.4553903044912619 0.6870344053078804 0.667565435141727 0.7120523108617077 0.9540056528275143 1.1021424892462595 1.0363972164760473 1.0 16.805903039931515 -7.1643012355752695 1.403233046443314 1.0643224746829496 0.5792221028815818 0.8971386702230892 0.06831394059694894 0.12677039224852854 0.4936211535321549 0.04106033299658505 0.0261789754969968 6.850129225946898e-08 7.1643012355752695 -0.4851003718013678 NEEPS(ph)EEEIDAPK ddPTM_A459_Selumetinib_30min_R1 2 NEEPSEEEIDAPK 13 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 NEEPS(1)EEEIDAPK;NEEPS(1)EEEIDAPK 176.42 0.00010117 14212100.0 2926.98 4584.84 2753.1 3241.9 2837.21 3380.38 3183.0299999999997 2764.97 1651.09 3204.92 True False 2995.172939088355 4048.044801365709 2379.2441416958086 2675.7630229999304 2580.5848564501093 3346.3764463394655 2942.9314844278456 2691.634013711673 2801.779139157621 3616.302700564429 0.8282417671012086 1.1193877107505117 0.6579217335220469 0.7399167726148311 0.7135975802156534 0.9253585010505803 0.8137956714653659 0.7443055066412348 0.7747634451950944 1.0 11.820299727438863 -5.264454310995223 24.99890479397736 0.7873554190693646 0.973814733328586 0.27141645798196135 0.11567205424868712 289.7117789952679 2402225.407995447 0.028807835835777326 0.06439224192329203 5.4393335203372625e-06 5.264454310995223 0.18645931425922146 NEEPS(ph)EEEIDAPK ddPTM_A459_Selumetinib_30min_R2 2 NEEPSEEEIDAPK 13 0 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 NEEPS(1)EEEIDAPK;NEEPS(1)EEEIDAPK 182.49 0.0001179 50121000.0 106987.0 87020.0 95606.0 90882.0 90037.0 86809.0 113179.0 112517.0 84155.0 73461.0 True False 101041.09084289455 93694.15418659891 89454.81404794232 78503.71481980532 78725.74711900737 98766.15177635752 118442.04775993378 112844.4058418079 100988.35148716238 71339.99005539986 1.4163317203216594 1.313346891607914 1.253922435067277 1.1004166773620572 1.103528989250938 1.3844430269707015 1.660247606818508 1.581783313316659 1.4155924525464436 1.0 16.122423394246432 -6.98598032748221 16.598474433409447 1.4713815518340605 1.2359100353579684 0.14863105229694418 0.18652828667260135 6.245934405116793 7391.910344595888 0.06512220236070154 0.05725810914079852 1.0328081884817355e-07 6.98598032748221 -0.2354715164760921 NEEPS(ph)EEEIDAPKPK ddPTM_A459_Selumetinib_30min_R1 8 NEEPSEEEIDAPKPK 15 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK 171.52 0.00021496 2620726000.0 27518.6 43236.200000000004 41574.899999999994 45860.700000000004 29881.6 35294.7 34784.899999999994 29081.3 17043.63 27306.55999999999 True False 28159.72983812556 38174.08560403596 35929.256934578836 37851.989656958234 27178.814556024972 34939.66736302356 32161.046987516325 28309.969454624566 28921.795292516446 30811.622964418635 0.913932053194488 1.2389508221660221 1.1660942682594182 1.2284971064545946 0.8820961683002274 1.1339768568300348 1.0437959410530244 0.918808122743713 0.938665104591064 1.0 14.911187056118564 -7.024504416415479 0.8798294962341108 0.9527263997458711 1.1295217586679993 0.2158615828867505 0.11437262346391032 0.8541564919635907 1.365750695095495 0.08118746914608047 0.058260469433402934 9.451387811126084e-08 7.024504416415479 0.17679535892212817 NEEPS(ph)EEEIDAPKPK ddPTM_A459_Selumetinib_30min_R2 7 NEEPSEEEIDAPKPK 15 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK;NEEPS(1)EEEIDAPKPK 170.0 0.00026351 1943621700.0 1023177.0 984438.0 952137.0 966329.0 872719.0 769108.0 887162.0 883131.0 648336.0 902682.0 True False 966312.9184420563 1059941.2291329228 890877.5420283824 834713.3231894942 763080.2370131491 875045.6457327094 928416.7908781541 885700.7649997924 778021.3160213995 876619.2252105013 1.1023177346013795 1.209123868893476 1.0162651199150432 0.952196003902442 0.8704808371387379 0.9982049452800741 1.0590878732498876 1.0103597314867356 0.8875248153890012 1.0 19.74159079351351 -5.410964073874648 4.563422197061039 0.9704637118221081 1.1539351554281296 0.6131704703551227 0.058564692902399594 0.1488731494549254 4.902773218221779 0.016416040361206537 0.03555716224709802 3.881824762662244e-06 5.410964073874648 0.18347144360602152 NEEPSEEEIDAPKPK ddPTM_A459_Selumetinib_30min_R1 1 NEEPSEEEIDAPKPK 15 1 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 0 100.23 0.021769 7820800.0 5347.5 7390.9 6857.4 7383.9 5546.5 6352.6 6348.6 6115.5 3096.0 5347.2 False True 5472.086345576318 6525.569992063807 5926.202745001934 6094.44047796946 5044.820054314112 6288.6986116993085 5869.71999071282 5953.297074056402 5253.685877106632 6033.565206138724 0.9069407818794863 1.0815446206538886 0.9822058008045466 1.010089436303564 0.836125886098217 1.0422856796676374 0.9728443781034797 0.9866964009934533 0.8707432003488386 1.0 12.558795020664695 NEEPVRS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 NEEPVRSPER 10 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 NEEPVRS(1)PER 82.774 0.022982 16202000.0 2653.5 2636.3 1980.2 2102.5 2198.1 1856.9 2418.9 2413.1 1499.6 2174.4 True False 2715.3213871877983 2327.640770417381 1711.2997164600038 1735.337843812998 1999.2822431060738 1838.2212719303027 2236.4404255324384 2349.096749146516 2544.711673549452 2453.505420449588 1.1067109795462502 0.948700072564281 0.6974917202939864 0.7072891827950432 0.8148676691081933 0.7492224213604799 0.9115286263042476 0.957445102654821 1.0371738543308988 1.0 11.260628743370898 -7.694726638911707 2.416679520179186 1.0093518732465065 0.8294443710997802 0.2795811570642799 0.11544433735341683 0.4158444298897608 4.865074645321287 0.07881801973688664 0.03644817932007771 2.019637198400645e-08 7.694726638911707 -0.17990750214672635 NEEPVRS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 NEEPVRSPER 10 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 NEEPVRS(1)PER 66.19 0.047567 66002000.0 17272.0 16189.0 15376.0 19552.0 15614.0 14085.0 17558.0 20490.0 12205.0 16325.0 True False 16312.091385294216 17430.644244160507 14386.724900122992 16888.98387091873 13652.429729068937 16025.08089910029 18374.481790516973 20549.622507697903 14646.341036192951 15853.654832556107 1.028916773928791 1.0994716630493298 0.9074705518742141 1.0653053853699739 0.8611534610324134 1.0108130313391304 1.1590060452675082 1.296207261022136 0.9238463427446465 1.0 13.952527850890288 -7.179680138247584 6.266604127678757 1.119079117723964 0.9923656080729358 0.14317838444658681 0.11312969034895559 0.36832632134614046 22.989293476699643 0.042643860640800064 0.03286388795817321 6.611802338532119e-08 7.179680138247584 -0.12671350965102823 NEGS(ph)ESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R1 1 NEGSESAPEGQAQQR 15 0 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NEGS(0.5)ES(0.5)APEGQAQQR 95.873 0.010538 386750.0 213.07 0.0 134.66 0.0 209.86 76.993 178.01 170.53 69.913 181.28 True False 218.0341164379515 0.0 116.37391163443296 0.0 190.87820005379228 76.21852032405069 164.58256238332677 166.0069904404936 118.63725475651033 204.54905381673163 1.0659258127554185 0.0 0.5689291124206307 0.0 0.9331658909789535 0.37261732040246764 0.8046117022412954 0.8115754502058451 0.579994150756644 1.0 7.676303053536659 -7.037306385348495 1.051241746066989 0.8017199023741921 0.42524818911476886 0.1498702878344782 0.3382603550389855 0.9354249250129395 2.1139648573593304 0.20427674543281404 0.14156976099919216 9.176849612045648e-08 7.037306385348495 -0.37647171325942325 NEGS(ph)ESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R2 2 NEGSESAPEGQAQQR 15 0 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NEGS(1)ESAPEGQAQQR;NEGS(0.734)ES(0.266)APEGQAQQR 236.68 6.708499999999998e-20 208811000.0 23160.2 15893.3 18577.1 22629.0 21708.7 17194.1 23299.0 26520.0 19755.5 17141.6 True False 21873.048801626417 17112.265004985864 17381.869611217142 19546.89116279767 18981.45902775963 19562.431202500553 24382.449666092652 26597.168809377647 23707.152014789823 16646.677468774516 1.3139588270785818 1.027968796601285 1.0441644973191608 1.1742217748534693 1.140255108766578 1.1751552968570063 1.46470367506241 1.597746388687355 1.4241371624613497 1.0 14.022946636266367 -7.191970230392197 4.971299354177368 1.4212495008011579 1.1338276388551736 0.29825968253079793 0.16267294709028812 0.21330873307647702 10.152787452564688 0.061453450003887224 0.04672304281173625 6.427317731773559e-08 7.191970230392197 -0.2874218619459843 NEGSES(ph)APEGQAQQR ddPTM_A459_Selumetinib_30min_R1 3 NEGSESAPEGQAQQR 15 0 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NEGS(0.1)ES(0.9)APEGQAQQR;NEGS(0.283)ES(0.717)APEGQAQQR;NEGS(0.099)ES(0.901)APEGQAQQR 292.45 2.2525999999999997e-67 43160400.0 3116.41 3570.25 1882.1699999999998 1995.88 1829.95 1897.1799999999998 2844.38 2888.79 1510.12 2642.93 True False 3189.016289521739 3152.243470235804 1626.5816520197588 1647.3370253077221 1664.4313456039133 1878.0960917016164 2629.8261265765254 2812.1699050876296 2562.5633451990543 2982.175809818261 1.0693589154007936 1.057028046387348 0.5454345269197545 0.552394335667324 0.5581264994921097 0.6297737663615718 0.8818481183833329 0.9429926618776403 0.8592931834408587 1.0 11.542149596769127 -7.418022963519315 5.712932465230703 0.9234430313737161 0.7255277575415435 0.19839310250714304 0.18391136248698753 0.4398306714875933 19.932726651561637 0.0895932133267031 0.059403860404938495 3.819240758959925e-08 7.418022963519315 -0.19791527383217256 NEGSES(ph)APEGQAQQR ddPTM_A459_Selumetinib_30min_R2 2 NEGSESAPEGQAQQR 15 0 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NEGS(0.381)ES(0.619)APEGQAQQR;NEGSES(1)APEGQAQQR 143.69 0.00037636 2412000.0 5489.9 3450.9 5150.5 6726.5 5903.7 2087.8 7121.799999999999 6717.3 4367.1 3306.8 True False 5184.79333581095 3715.572933607604 4819.122437440396 5810.33909614028 5162.024426252355 2375.375498838593 7452.97781157898 6736.846230891124 5240.642026969129 3211.3240919017794 1.614534437332503 1.1570220965792348 1.500665239485829 1.8093281555706628 1.6074442437217074 0.7396872538741087 2.320842617652225 2.0978406532931073 1.6319256098083723 1.0 11.648952556136532 -7.281042720830253 24.998425329968242 1.8541388409565334 1.4254773608315656 0.129715450582241 0.42665685955350013 1443.931132941938 1841311.4317194058 0.1752410048449355 0.11832657818337493 5.2354893340954985e-08 7.281042720830253 -0.42866148012496774 NEHRPAS(ph)ALVNPLAR ddPTM_A459_Selumetinib_30min_R2 2 NEHRPASALVNPLAR 15 1 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 NEHRPAS(1)ALVNPLAR;NEHRPAS(1)ALVNPLAR 80.585 0.015895 33372000.0 50845.0 52867.0 54424.0 63982.0 56305.0 29570.0 58513.0 47727.0 36250.0 47350.0 True False 48019.2384486617 56921.72890580232 50922.419092370816 55267.54122489368 49231.462526913434 33642.999090265905 61233.970441309895 47865.87766836979 43501.012909626734 45982.8824699254 1.0442850876098984 1.2378895329806991 1.107421204524881 1.2019155445733705 1.0706475949852152 0.7316418041489622 1.3316688113529922 1.0409499165189555 0.9460262291751305 1.0 15.488809284812243 -6.515797728575658 24.910852315638156 1.0180982705883728 1.1495255164055356 0.16637001322414458 0.14485480692157587 620.2372055176148 2181990.0270786905 0.046758289225349726 0.04858415257353735 3.0493148687096397e-07 6.515797728575658 0.1314272458171628 NEIIQS(ph)PISQVPSVEK ddPTM_A459_Selumetinib_30min_R1 2 NEIIQSPISQVPSVEK 16 0 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 NEIIQS(0.996)PIS(0.004)QVPSVEK;NEIIQS(0.999)PIS(0.001)QVPSVEK 197.94 1.0027e-06 7839600.0 10893.0 12349.2 14219.5 14847.6 12547.300000000001 10956.1 11670.7 12059.699999999999 7222.799999999999 10987.2 True False 11146.785705911703 10903.349923012678 12288.570002122528 12254.745383970438 11412.398930405745 10845.891581342878 10790.369702865528 11739.837580573634 12256.564067560012 12397.51414439097 0.8991145786233979 0.8794787242042148 0.9912124204094792 0.9884840816668778 0.9205392950141603 0.8748440578508961 0.8703655891973662 0.9469509325694224 0.9886307791070575 1.0 13.59776325088035 -8.16657574881768 3.440617759096419 0.9959859939051418 0.9197702546811274 0.355042257336879 0.04065825986101887 0.3182415981664581 6.721436663287815 0.0373890706872124 0.01204113093890173 6.814347098146392e-09 8.16657574881768 -0.07621573922401437 NEIIQS(ph)PISQVPSVEK ddPTM_A459_Selumetinib_30min_R2 2 NEIIQSPISQVPSVEK 16 0 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 NEIIQS(0.72)PIS(0.071)QVPS(0.208)VEK;NEIIQS(1)PISQVPSVEK 216.16 1.4431e-10 11322800.0 86217.0 90174.0 91433.0 108523.0 102398.0 79994.0 97529.0 90128.0 68812.0 101458.0 True False 81425.40429399667 97090.05584489017 85550.30032472315 93741.98018738306 89533.84779026516 91012.4473867681 102064.29175004721 90390.25755850649 82576.32276792354 98528.64392045826 0.8264135286357036 0.985399290822175 0.8682784713223856 0.9514185566489736 0.9087088203765947 0.9237156197972444 1.0358844665764737 0.9174008081495383 0.838094583282675 1.0 16.58825558061148 -5.78492435661266 24.98902536455015 0.9379740964212375 0.9025672802667205 0.09675399468838342 0.06237756621364127 691.4601372564906 735741.1856734485 0.01745180027623737 0.025901598683341215 1.6408755483614153e-06 5.78492435661266 -0.03540681615451702 NEIIQSPISQVPS(ph)VEK ddPTM_A459_Selumetinib_30min_R2 1 NEIIQSPISQVPSVEK 16 0 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 NEIIQSPISQVPS(1)VEK 213.64 5.163199999999999e-39 0.0 17813.0 14179.0 14627.0 17271.0 16121.0 8139.0 11904.0 15182.0 12601.0 20398.0 True False 16823.024771088825 15266.483707329162 13685.914744673453 14918.660005863203 14095.73585643144 9260.073371514178 12457.559587328504 15226.177106484602 15121.552101357422 19809.056739631207 0.8492592551078748 0.7706820121720437 0.6908917938173491 0.7531231901626099 0.7115803665820519 0.4674666488782331 0.6288820185165682 0.7686472559807547 0.7633655807095712 1.0 14.27387256369125 -8.773497895813806 1.557498234530218 0.9989769072745043 0.6966057197610203 0.4564554629156299 0.09664990813990292 0.8988948433004389 3.7810875281839667 0.10147547285462313 0.029284843509499118 1.6846205888551854e-09 8.773497895813806 -0.302371187513484 NEKPTQSVS(ph)SPEATSGSTGSVEK ddPTM_A459_Selumetinib_30min_R2 2 NEKPTQSVSSPEATSGSTGSVEK 23 1 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 NEKPT(0.002)QS(0.006)VS(0.484)S(0.484)PEAT(0.014)S(0.007)GS(0.001)T(0.001)GS(0.001)VEK;NEKPTQSVS(0.984)S(0.016)PEATSGSTGSVEK 123.38 5.7482e-06 39713000.0 73223.0 71901.0 81785.0 76810.0 68372.0 57765.0 71471.0 76584.0 55743.0 78458.0 True False 69153.55879489335 77415.57550184595 76523.04214077533 66348.34549535939 59782.49810656477 65721.60441153917 74794.54311709975 76806.84676083627 66893.15758955375 76192.71368163469 0.9076138052235034 1.0160495900608146 1.0043354337072294 0.8707964618846727 0.7846222455911109 0.8625707267252846 0.9816495502394482 1.0080602599582906 0.8779469106332345 1.0 16.21736541876431 -10.129000051041128 15.62731694002534 0.9999999882911357 0.9255593887890081 0.08825543126180702 0.07332493561165224 0.0 0.0 0.07904663811888432 0.01917162578318444 7.430190505722373e-11 10.129000051041128 -0.07444059950212756 NEKPTQSVSS(ph)PEATSGSTGSVEK ddPTM_A459_Selumetinib_30min_R1 2 NEKPTQSVSSPEATSGSTGSVEK 23 1 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 NEKPTQSVS(0.013)S(0.814)PEAT(0.101)S(0.061)GS(0.008)T(0.002)GSVEK;NEKPTQSVS(0.152)S(0.848)PEATSGSTGSVEK 176.68 8.4349e-17 87892000.0 10022.400000000001 12775.0 12709.5 13278.0 10681.6 11903.599999999999 11816.2 10319.2 6459.5 10018.5 True False 10255.902419804417 11279.29706106363 10983.61970828625 10959.246558929353 9715.451165989653 11783.860591604047 10924.8945207228 10045.50129451441 10961.299716786274 11304.47206345392 0.9072429355600417 0.9977730050329657 0.9716172189761122 0.969461156382469 0.8594343116118273 1.0424069806585603 0.9664223556305428 0.8886307328752113 0.9696427798891127 1.0 13.464605997094724 NEKPTQSVSS(ph)PEATSGSTGSVEK ddPTM_A459_Selumetinib_30min_R2 2 NEKPTQSVSSPEATSGSTGSVEK 23 1 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 NEKPTQSVS(0.306)S(0.694)PEATSGSTGSVEK;NEKPTQSVS(0.07)S(0.93)PEATSGSTGSVEK 136.16 2.8443e-06 44153000.0 110005.0 98823.0 105786.0 108518.0 120144.0 84848.0 103893.0 101201.0 78655.0 99323.0 True False 103891.36248490567 106402.40633397213 98979.84393108818 93737.6611960083 105050.43661901233 96535.04182654315 108724.23036007394 101495.47815527246 94388.19780432244 96455.28691785403 1.0770934990156067 1.1031267412494408 1.0261733399371273 0.9718250206008905 1.0891101978523825 1.000826858861112 1.1271982473357707 1.0522541728760904 0.9785694576255626 1.0 16.557572697151237 -7.739408600577235 0.007365846202223255 1.7810772072480695e-08 2.0749184922370176 0.13175427529820138 0.04860118689530721 4663.129508232502 32.52809667622478 4563.792746167291 4595.223987463061 1.8221805196485194e-08 7.739408600577235 2.0749184744262457 NEKPTQSVSS(ph)PEATSGSTGSVEKK ddPTM_A459_Selumetinib_30min_R2 1 NEKPTQSVSSPEATSGSTGSVEKK 24 2 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 NEKPT(0.002)QS(0.007)VS(0.23)S(0.732)PEAT(0.018)S(0.004)GS(0.005)T(0.001)GS(0.001)VEKK 59.614 0.0036663 6578300.0 23561.0 23369.0 22452.0 25534.0 22729.0 14102.0 14330.0 12969.0 9482.4 25237.0 True False 22251.57394215593 25161.327156821724 21007.462763889274 22056.22515139314 19873.579820161904 16044.422494789644 14996.373394356311 13006.737642866477 11379.144960392954 24508.3422363993 0.9079183621448021 1.0266433736775809 0.8571555987450432 0.8999476561346396 0.8108904155355746 0.6546514790772257 0.6118885255357662 0.5307065454451313 0.46429680353870995 1.0 14.580985282023875 -6.584705490786692 1.6047701084610735 0.6100622943820109 0.9355148881286359 0.44691463139418364 0.13963915963626355 0.3007320426290443 1.5890948614668963 0.05413898417608678 0.0566478213606153 2.6019234139281484e-07 6.584705490786692 0.32545259374662505 NEKPTQSVSSPEATS(ph)GSTGSVEKK ddPTM_A459_Selumetinib_30min_R2 1 NEKPTQSVSSPEATSGSTGSVEKK 24 2 H0YE68;Q9BZ95-3;Q9BZ95-4;Q9BZ95-2;Q9BZ95-5;Q9BZ95 H0YE68 WHSC1L1 Histone-lysine N-methyltransferase NSD3 1 NEKPTQSVS(0.001)S(0.003)PEAT(0.356)S(0.468)GS(0.079)T(0.079)GS(0.014)VEKK 66.64399999999999 0.00097924 4563200.0 27743.0 27964.0 26933.0 30160.0 26855.0 16972.0 19581.0 16909.0 9851.9 32525.0 True False 26201.155124028355 30108.748881568008 25200.160102433187 26052.15597109804 23481.234813253886 19309.738943523596 20491.555299015414 16958.20239056436 11822.555285085562 31585.91873990121 0.8295201206520391 0.9532332787120371 0.7978289411160564 0.8248028555264851 0.7434083208601114 0.6113401070436614 0.6487560316910859 0.5368912182105297 0.3742982872348939 1.0 14.946993916061652 -6.460004351460917 1.3279068786160313 0.5974980900680659 0.8727928258883493 0.30017997472949876 0.15216533501358523 0.4592108818705711 1.6659274228227352 0.06131062577704632 0.07252159508022644 3.467333763022552e-07 6.460004351460917 0.2752947358202834 NELDS(ph)PHEEK ddPTM_A459_Selumetinib_30min_R2 2 NELDSPHEEK 10 0 Q8TBZ6 Q8TBZ6 TRMT10A tRNA methyltransferase 10 homolog A 1 NELDS(1)PHEEK;NELDS(1)PHEEK 135.81 0.0030508 4362500.0 90134.0 54083.0 66178.0 81690.0 89857.0 84735.0 142345.0 144512.0 96719.0 63756.0 True False 85124.71311499014 58230.99219574605 61920.179529158406 70563.68107688993 78568.36032822779 96406.47710225504 148964.32455126639 144932.50599475036 116065.50255465375 61915.1986220182 1.3748597276520438 0.9404959281684032 1.000080447244797 1.1396827054964203 1.2689672661453342 1.5570728875602944 2.4059411560749138 2.340822757906968 1.87458822934921 1.0 15.91800597776336 -6.914092233642266 2.8532701043183892 2.0159854444611987 1.1162022298364696 0.455518527185226 0.38215035886398213 0.20158011901479997 3.3195028001235607 0.1434747576709437 0.12212621428283675 1.2187307425101072e-07 6.914092233642266 -0.8997832146247291 NELMYQLEQDHDLQAILQER ddPTM_A459_Selumetinib_30min_R1 1 NELMYQLEQDHDLQAILQER 20 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 157.0 3.0953e-05 4580300.0 982.83 1076.5 1088.4 883.17 829.04 878.98 839.12 830.3 532.46 894.28 False True 1005.7280267457264 950.4628795487272 940.6012581532519 728.9409386541374 754.0534783789004 870.1382592499848 775.8245028206126 808.2777468054993 903.545730660271 1009.0695490248613 0.9966885114288068 0.9419200891229251 0.9321471042924887 0.7223891944401326 0.7472760218635061 0.8623174290522034 0.7688513676488893 0.8010129208503002 0.8954246330527308 1.0 9.97880989872513 -5.603328115358028 7.400734035792986 0.8156492747809254 0.9614212831332978 0.36502864735892293 0.0774333833946197 0.2109886302937583 16.356332183951423 0.0203649978370364 0.035452911717916674 2.492710738648389e-06 5.603328115358028 0.14577200835237236 NELQEPCDS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 NELQEPCDSPK 11 0 O94913 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 NELQEPCDS(1)PK;NELQEPCDS(1)PK;NELQEPCDS(1)PK 182.02 3.8863e-05 60526000.0 8097.7 8994.7 10117.0 10955.1 6609.4 8202.1 7031.5 7736.2 6454.6 7772.6 True False 8286.360654618677 7941.596342477413 8743.166968703088 9041.997437695965 6011.580936984347 8119.59432091094 6501.108293906876 7531.010845280867 10952.984774668117 8770.28892153535 0.9448218557853445 0.9055113706661257 0.9969075188884982 1.0309805661582525 0.6854484488216773 0.9258069367559105 0.7412650087209185 0.8586958665396475 1.248873882338492 1.0 13.098408655131456 -8.246275529069564 24.917094287242406 1.1244369440147255 0.8851410767554575 0.40825222817985407 0.11473329506558975 655.8354749854453 1077667.2133343942 0.07878787933536002 0.029535564955465637 5.671846527735782e-09 8.246275529069564 -0.239295867259268 NELQEPCDS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 NELQEPCDSPK 11 0 O94913 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 NELQEPCDS(1)PK;NELQEPCDS(1)PK;NELQEPCDS(1)PK 167.03 0.00056067 110380000.0 179578.0 175329.0 167566.0 156714.0 135238.0 115054.0 152193.0 129520.0 92601.0 141320.0 True False 169597.77366769142 188776.17052840933 156784.98599206642 135369.28285327108 118248.1933969402 130901.64414377596 159270.27606470828 129896.88175680976 111123.78748811992 137239.72440654368 1.235777573884467 1.3755213466415876 1.142416939920573 0.9863709901680375 0.8616178290088584 0.9538174512505395 1.1605260558007515 0.9464962299983763 0.8097057026939167 1.0 17.066338608347145 -5.5781813328401615 2.8579123704348226 0.9605045855877167 1.303892333447981 0.694632897447677 0.09261609281382113 0.14900668057427988 2.451129033163362 0.027510298764957555 0.05672651255376119 2.6413056913453066e-06 5.5781813328401615 0.3433877478602644 NEMGIPQQTT(ph)SPENAGPQNTK ddPTM_A459_Selumetinib_30min_R2 1 NEMGIPQQTTSPENAGPQNTK 21 0 Q15398-1;Q15398;Q15398-3 Q15398-1 DLGAP5 Disks large-associated protein 5 1 NEMGIPQQT(0.073)T(0.545)S(0.383)PENAGPQNTK 125.82 0.00045106 0.0 26927.0 25896.0 28431.0 29741.0 28794.0 21674.0 23999.0 26524.0 19486.0 28266.0 True False 25430.505137321546 27882.13993123604 26601.78041333226 25690.224493913345 25176.640298373954 24659.39676301737 25115.001053116328 26601.180448715426 23383.744484330677 27449.887136112146 0.9264338687887002 1.015746978957711 0.9691034531918296 0.9358954507363403 0.9171855670492872 0.8983423735311573 0.9149400479711219 0.96908159646747 0.8518703325948401 1.0 14.74451259695821 -5.821954432202264 3.360410681966299 0.9221979807210432 0.9758571951919919 0.1819709561570254 0.0423082738560019 0.33473021859436786 7.627421071152727 0.011528795392801798 0.018884744558798638 1.5067651533158643e-06 5.821954432202264 0.05365921447094868 NENTEGS(ph)PQEDGVELEGLK ddPTM_A459_Selumetinib_30min_R1 3 NENTEGSPQEDGVELEGLK 19 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 NENT(0.012)EGS(0.988)PQEDGVELEGLK;NENTEGS(1)PQEDGVELEGLK;NENTEGS(1)PQEDGVELEGLK 312.01 6.796599999999998e-117 21197100.0 17210.0 20844.4 17322.4 19019.5 15770.9 17358.4 17656.0 17007.0 7201.1 14309.8 True False 17610.959515169416 18403.927957701348 14970.113225132201 15698.101365232484 14344.42487957854 17183.79025616616 16324.193705072848 16555.919113478416 12219.740752465299 16146.602219255667 1.0906913588400304 1.1398019043135714 0.9271370547098484 0.9722232053572037 0.8883865896239188 1.0642356839430647 1.0109986908332576 1.025350032698187 0.7567995164885291 1.0 13.97894298551129 -5.259437105438838 24.991890683291103 0.960592374350444 1.1152466431070873 0.37282335228303265 0.08260442758902474 180.8085134195878 2256763.7635005265 0.021019559267897548 0.05021758987511595 5.502536025109634e-06 5.259437105438838 0.15465426875664334 NENTEGS(ph)PQEDGVELEGLK ddPTM_A459_Selumetinib_30min_R2 4 NENTEGSPQEDGVELEGLK 19 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 NENT(0.001)EGS(0.999)PQEDGVELEGLK;NENT(0.002)EGS(0.998)PQEDGVELEGLK;NENT(0.005)EGS(0.995)PQEDGVELEGLK;NENTEGS(1)PQEDGVELEGLK 248.33 1.4274e-37 89075000.0 217286.0 166394.0 198909.0 208024.0 218708.0 175551.0 202478.0 214657.0 156179.0 186404.0 True False 205210.11398477553 179155.8847589627 186111.41149574463 179690.7723385844 191231.94576567237 199731.55675668817 211893.62820254551 215281.61633162055 187419.16400586447 181022.03218424463 1.1336195462434773 0.9896910480853371 1.0281146954881162 0.9926458684084085 1.0564014968688236 1.103354958215257 1.1705405449590782 1.1892564332307707 1.0353389681047709 1.0 17.465805772787014 -6.708144813407368 3.4734167475894635 1.11696683392786 1.0316303139743934 0.15364416472564446 0.06502887613898443 0.3211070301627993 7.893561228694632 0.022483688732186913 0.021651646861490955 1.958191615051288e-07 6.708144813407368 -0.08533651995346658 NEPT(ph)TRSPVSSQQSLK ddPTM_A459_Selumetinib_30min_R1 1 NEPTTRSPVSSQQSLK 16 1 Q8IWJ2 Q8IWJ2 GCC2 GRIP and coiled-coil domain-containing protein 2 1 NEPT(0.444)T(0.11)RS(0.444)PVS(0.001)SQQSLK 79.346 0.034358 7353200.0 1449.7 1512.7 2330.0 2676.3 1803.8 1798.9 1654.7 1656.2 1080.9 1338.4 True False 1483.4751893748462 1335.5923807648483 2013.598797773867 2208.934445372996 1640.646608486756 1780.8046992705165 1529.8846467933877 1612.2721959042146 1834.2083541875184 1510.1966771199998 0.9823059551447879 0.8843830747342603 1.3333354709890328 1.4626799799252073 1.0863794321250453 1.1791872715986742 1.013036692486262 1.0675908776192493 1.2145493245856034 1.0 10.560520732641859 -7.236241871749754 23.512567313444656 1.0794267671186568 1.1614359841259703 0.05479415501198959 0.1625442438053247 1362.2061308999923 1271117.2613825928 0.06850684892335257 0.05303341753465318 5.804410622800333e-08 7.236241871749754 0.08200921700731345 NES(ph)PPQVPVYNNSHK ddPTM_A459_Selumetinib_30min_R2 2 NESPPQVPVYNNSHK 15 0 A0A087WTW5;Q9UKL3 A0A087WTW5 CASP8AP2 CASP8-associated protein 2 1 NES(1)PPQVPVYNNSHK;NES(0.996)PPQVPVY(0.004)NNSHK 109.03 0.0025454 22217000.0 67911.0 67535.0 67427.0 71273.0 63925.0 50718.0 57338.0 59765.0 47435.0 63873.0 True False 64136.778489272634 72714.71734074864 63088.820228966724 61565.49444721721 55894.1700032491 57703.944127835886 60004.33061309159 59938.90625537161 56923.32544463849 62028.8205280157 1.033983524808518 1.1722730937291737 1.0170888256769652 0.9925304708866868 0.9010999971860525 0.9302763398793557 0.9673621084893959 0.9663073672068265 0.9176915659540668 1.0 15.920651072014161 -5.627448050746724 2.427153990941434 0.9472886394069849 1.1026449378846188 0.6505160109145075 0.04334965724182993 0.1553183372233986 1.8415702036200032 0.011879604608137638 0.024787069048763027 2.358044242628888e-06 5.627448050746724 0.15535629847763388 NESS(ph)PAPPDSDADK ddPTM_A459_Selumetinib_30min_R2 2 NESSPAPPDSDADK 14 0 J3KTD7;Q8ND04;Q8ND04-2 J3KTD7 SMG8 Protein SMG8 1 NES(0.029)S(0.969)PAPPDS(0.001)DADK;NES(0.083)S(0.917)PAPPDSDADK 191.36 0.00010611 11141800.0 88208.0 58163.0 69531.0 77554.0 69596.0 74092.0 104069.0 105125.0 81936.0 61328.0 True False 83305.75248460125 62623.91507647833 65057.451159628705 66991.01141188784 60852.72828386589 84297.5004597898 108908.41470881138 105430.89634561935 98325.48948312219 59557.30129071982 1.3987496189250923 1.051490140071816 1.0923505556784843 1.1248161007981456 1.0217509350670984 1.4154016154678415 1.8286324656853017 1.7702430106927547 1.6509393030278758 1.0 15.86199076236965 -6.96374710903143 4.788504157537495 1.627796288043423 1.132720758597669 0.4151619968914746 0.234122212753135 0.1586621197126967 8.650172986244693 0.08169353654202403 0.07005029382679329 1.0870584367157369e-07 6.96374710903143 -0.49507552944575384 NESS(ph)PAPPDSDADKLK ddPTM_A459_Selumetinib_30min_R1 1 NESSPAPPDSDADKLK 16 1 J3KTD7;Q8ND04;Q8ND04-2 J3KTD7 SMG8 Protein SMG8 1 NES(0.098)S(0.901)PAPPDSDADKLK 169.02 5.7266e-05 9490500.0 2651.0 3180.9 2312.3 2523.7 2085.6 2572.8 2757.2 2906.9 1749.0 2943.1 True False 2712.7631420519538 2808.47874923971 1998.3023605547246 2082.9831707162252 1896.9578482425875 2546.919967915495 2549.2221841655437 2829.7995690580615 2967.9252580941547 3320.875553221664 0.8168819031535929 0.8457043042504663 0.6017396100905141 0.6272391534502012 0.5712222026514368 0.7669423099714364 0.7676355657749595 0.8521245447794038 0.8937176990010651 1.0 11.697347944836661 -8.004895058599029 1.0820773332360032 0.9836750521469869 0.6961770060526266 0.5788627866969129 0.08483965838613075 0.39593034467379334 0.8540528446561338 0.08682461647524435 0.03112700934118067 9.887919940344894e-09 8.004895058599029 -0.28749804609436036 NESS(ph)PAPPDSDADKLK ddPTM_A459_Selumetinib_30min_R2 4 NESSPAPPDSDADKLK 16 1 J3KTD7;Q8ND04;Q8ND04-2 J3KTD7 SMG8 Protein SMG8 1 NES(0.264)S(0.736)PAPPDSDADKLK;NES(0.247)S(0.753)PAPPDSDADKLK;NES(0.194)S(0.806)PAPPDSDADKLK;NES(0.107)S(0.893)PAPPDSDADKLK 121.82 0.00082207 91532000.0 413606.0 333870.0 345122.0 363841.0 346258.0 288109.0 387195.0 365408.0 267231.0 317896.0 True False 390619.43431600265 359476.7554387459 322917.22626042156 314285.22813926655 302757.9744542047 327793.3995568964 405200.33471233683 366471.27678344876 320684.6670579987 308717.51648699865 1.2652972813496095 1.164419691922097 1.045995802036134 1.0180349716323998 0.9806958085805769 1.0617907376522353 1.3125278387933697 1.187076395773229 1.0387640802089182 1.0 18.23592781755176 -4.924615873598334 3.2109117593749317 1.089393824317473 1.2677503155350864 0.2685989590566582 0.09475006815119619 0.4379380945000282 8.136286871592404 0.02717590373139426 0.16403564167357593 1.1895539033424091e-05 4.924615873598334 0.17835649121761343 NESSDSALGDS(ph)ESEDTGHDMTR ddPTM_A459_Selumetinib_30min_R2 2 NESSDSALGDSESEDTGHDMTR 22 0 J3KNG8;Q8TF40;A0A087WX11;Q8TF40-3 J3KNG8 FNIP1 Folliculin-interacting protein 1 1 NESSDSALGDS(1)ESEDTGHDMTR;NESSDSALGDS(0.999)ES(0.001)EDTGHDMTR 209.46 1.27e-23 17138800.0 91115.0 71469.0 90917.0 95474.0 96668.0 70339.0 70827.0 75586.0 63326.0 86441.0 True False 86051.19306224422 76950.44249094476 85067.49920294501 82470.27649816347 84523.70161711509 80027.55877613163 74120.59584103791 75805.94274606412 75992.9694762765 83945.22372930974 1.025087422957206 0.9166744583239137 1.0133691403009915 0.9824296467908359 1.006891135220161 0.9533306985301386 0.882963825077739 0.9030405707239331 0.9052685322672303 1.0 16.357160621351817 -7.011770060263819 5.870957862791641 0.9148900783143574 0.9855672656719761 0.3698540184915423 0.040062689472265725 0.1592796721175599 20.57808767558036 0.014161746629613906 0.011613656589322787 9.732623868111007e-08 7.011770060263819 0.07067718735761863 NESSNAS(ph)EEEACEK ddPTM_A459_Selumetinib_30min_R2 2 NESSNASEEEACEK 14 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EN31 Q9H6Z4 RANBP3 Ran-binding protein 3 1 NESS(0.001)NAS(0.999)EEEACEK;NESSNAS(1)EEEACEK 149.09 0.00044691 10965800.0 36546.0 22614.4 33449.6 33821.5 33442.8 31097.0 42434.0 40281.0 33073.0 26773.2 True False 34514.919625229435 24348.851763243165 31297.489153170787 29214.95335465822 29241.41648157467 35380.32947954002 44407.26508137585 40398.21104112147 39688.52413682993 26000.18815087235 1.3274873022052112 0.9364875216268856 1.2037408718567564 1.1236439207720892 1.124661725980378 1.3607720557342564 1.7079593741280643 1.553766103795139 1.5264706511555886 1.0 14.66623444293196 -6.900877125621074 3.9714726533413964 1.4982360383176143 1.13444209540161 0.3434072235850467 0.19480951084253126 0.20593596500820385 6.086137882618692 0.06744430596816212 0.058860909238517396 1.2563853809127735e-07 6.900877125621074 -0.3637939429160044 NEVNGTSEDIKSEGDTQS(ph)N ddPTM_A459_Selumetinib_30min_R1 1 NEVNGTSEDIKSEGDTQSN 19 1 O95232 O95232 LUC7L3 Luc7-like protein 3 1 NEVNGTSEDIKS(0.002)EGDT(0.248)QS(0.75)N 143.57 0.00021903 0.0 684.89 726.96 556.43 466.69 626.53 334.41 562.5 699.34 249.76 612.76 True False 700.846604436048 641.8471852454645 480.869862251207 385.19135235628437 569.8604721228553 331.04613901998613 520.0701721286517 680.7912314235313 423.82447825134153 691.4137147878449 1.0136429021386963 0.9283113301309195 0.695487885135108 0.5571069015813165 0.8241960781725493 0.4787960260834067 0.752183766398431 0.9846365741131226 0.6129824578058722 1.0 9.4334054107603 -10.645662416045312 15.784656647523995 0.9999771105535566 0.757727950652569 0.14907564589449052 0.17129049388611903 0.0 0.0 0.17093074622460103 0.041456795373510436 2.2611927480777474e-11 10.645662416045312 -0.2422491599009876 NEVNGTSEDIKSEGDTQS(ph)N ddPTM_A459_Selumetinib_30min_R2 5 NEVNGTSEDIKSEGDTQSN 19 1 O95232 O95232 LUC7L3 Luc7-like protein 3 1 NEVNGTSEDIKS(0.132)EGDT(0.223)QS(0.645)N;NEVNGTSEDIKS(0.052)EGDT(0.026)QS(0.921)N;NEVNGTSEDIKS(0.142)EGDT(0.047)QS(0.811)N;NEVNGTSEDIKS(0.001)EGDT(0.012)QS(0.987)N;NEVNGTSEDIKSEGDT(0.02)QS(0.98)N 181.94 1.6234e-12 43002000.0 267329.0 193977.0 208129.0 218502.0 208640.0 189938.0 259107.0 252101.0 175158.0 190323.0 True False 252471.924382777 208854.4121656385 194738.20673372125 188741.6506630256 182428.77793473453 216100.23541450538 271155.98891078046 252834.57217243305 210194.49432343128 184827.88047145936 1.3659839832538851 1.129994087650046 1.0536192171710383 1.0211752154576625 0.9870198017171155 1.1691971734095334 1.4670729774053308 1.3679460670516919 1.1372445206170558 1.0 17.49582287179699 -7.008698005891304 24.794702403462065 1.2800719294661935 1.1017191105638178 0.12179693322363083 0.1530109335573282 580.3136602854877 1654254.086555939 0.05617343973131404 0.04713658948942094 9.801713274154771e-08 7.008698005891304 -0.17835281890237575 NFDFEGSLS(ph)PVIAPK ddPTM_A459_Selumetinib_30min_R1 2 NFDFEGSLSPVIAPK 15 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 NFDFEGS(0.469)LS(0.531)PVIAPK;NFDFEGS(0.102)LS(0.898)PVIAPK 185.86 2.1768e-05 296090000.0 16621.1 19627.4 22377.0 22740.0 17776.1 18191.2 19851.699999999997 19126.4 9869.5 15824.8 True False 17008.339290969332 17329.4148834693 19338.326308062577 18768.88588266709 16168.254893625357 18008.21304428806 18354.270286304625 18619.10574069699 16747.820660240286 17856.067226605337 0.9525243758954436 0.9705056921856046 1.0830115087855792 1.0511209240241695 0.9054768157198042 1.0085206790359764 1.0279010519716778 1.0427327308084242 0.9379344537461319 1.0 14.124126743466036 -8.267155894379453 24.890899591067726 0.9689672354502539 1.005730600077825 0.07490868189237254 0.05094082530783864 1444.7975191149046 6290843.98127965 0.046753449436210584 0.01328741039427896 5.405602485682473e-09 8.267155894379453 0.03676336462757113 NFDFEGSLS(ph)PVIAPK ddPTM_A459_Selumetinib_30min_R2 3 NFDFEGSLSPVIAPK 15 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 NFDFEGS(0.243)LS(0.757)PVIAPK;NFDFEGS(0.021)LS(0.979)PVIAPK;NFDFEGS(0.006)LS(0.994)PVIAPK 157.84 0.00015133 64241100.0 163417.0 136294.0 151091.0 183428.0 164155.0 112420.0 131032.0 144053.0 104942.0 151377.4 True False 154334.93735008247 146747.31154571712 141369.96955544257 158444.78996905065 143532.3813356801 127904.83455284714 137125.24763498222 144472.17038074217 125933.33232447035 147006.74113628062 1.0498493889270584 0.9982352537811651 0.9616563734610473 1.0778062879590435 0.9763659831260415 0.87006101600657 0.9327820382594708 0.9827588127187392 0.8566500512226548 1.0 17.165522787191613 -6.526092332604933 24.914712964215145 0.9271512994461767 1.0172941157729583 0.4378057453452071 0.0498406739235834 88.4691279538924 685884.4590781557 0.015793169731684393 0.015869351658222723 2.977883253186382e-07 6.526092332604933 0.09014281632678156 NFEHLNSDFDR ddPTM_A459_Selumetinib_30min_R2 3 NFEHLNSDFDR 11 0 P48163 P48163 ME1 NADP-dependent malic enzyme 0 ;; 196.67 2.8576e-05 21346700.0 152002.0 146214.0 173746.0 174009.0 201653.0 149502.0 137901.0 154228.0 129436.0 161453.0 False True 143554.33735221718 157428.14364788978 162567.37152034134 150308.6740177321 176319.54733930706 170094.54345596672 144313.66974564746 154676.77794617997 155326.81674401253 156791.43238472787 0.915575138059648 1.0040608804542304 1.0368383593909694 0.9586536185785415 1.12454835482759 1.0848459056015016 0.9204180837607056 0.986512946489582 0.9906588286206766 1.0 17.258487202297026 -4.766782376179451 4.54459484153612 1.0140660230435787 0.907981971926852 0.21256793894570492 0.055753132542270316 0.33055376236081824 15.324992530841488 0.014770963827390751 0.11397172194110072 1.7108724139859834e-05 4.766782376179451 -0.1060840511167267 NFELVDSS(ph)PCK ddPTM_A459_Selumetinib_30min_R2 1 NFELVDSSPCK 11 0 A0A087WUU7;Q96GX5-2;Q96GX5-3;Q96GX5 A0A087WUU7 MASTL Serine/threonine-protein kinase greatwall 1 NFELVDS(0.226)S(0.774)PCK 132.86 0.0019305 2879900.0 49209.0 48866.0 50517.0 52153.0 48243.0 41976.0 46305.0 40420.0 36294.0 46725.0 True False 46474.16077923483 52613.865071044995 47266.79121875086 45049.671431056864 42182.28304210788 47757.81297981069 48458.2742516168 40537.61550810877 43553.814139089474 45375.92784387043 1.02420298575807 1.1595105063653768 1.0416710680029844 0.9928099230513556 0.929618082681389 1.0524922629491094 1.0679291103060662 0.8933727073877292 0.9598440452600664 1.0 15.469639523089016 -5.590197517124475 3.66564485450138 0.9848267565477657 1.0940630216693497 0.3571275330019935 0.057622016739636364 0.2384757647936717 6.411007182786937 0.016494529073837885 0.031334428094772326 2.5692270325956773e-06 5.590197517124475 0.10923626512158391 NFETTQVCNES(ph)PHGDGYSSGVIK ddPTM_A459_Selumetinib_30min_R1 2 NFETTQVCNESPHGDGYSSGVIK 23 0 Q92628 Q92628 KIAA0232 Uncharacterized protein KIAA0232 1 NFET(0.001)T(0.001)QVCNES(0.993)PHGDGY(0.003)S(0.002)S(0.001)GVIK;NFETTQVCNES(0.999)PHGDGYSSGVIK 112.39 8.9037e-06 11186900.0 2883.1 3905.9 2499.8 2577.6 3333.0 3002.2 3717.5 3596.1000000000004 1155.9299999999998 3102.7 True False 2950.270620463969 3448.595412196354 2160.3408904185026 2127.470547544534 3031.5307384889434 2972.0005937795 3437.085982023579 3500.7197462209515 1961.528784213137 3500.9617678573127 0.8427028959729593 0.9850422943370192 0.6170706890468821 0.6076817425077469 0.8659136944372647 0.8489097541897603 0.9817547890924764 0.9999308699573405 0.5602828349118614 1.0 11.773535591608788 -6.489523075804245 24.27448566447181 0.8816191727170081 0.7645750608816025 0.11200672837827075 0.15602838857038942 1071.0561973003255 779457.8795502436 0.05001662790460297 0.056669071650358525 3.2394920925933404e-07 6.489523075804245 -0.11704411183540553 NFETTQVCNES(ph)PHGDGYSSGVIK ddPTM_A459_Selumetinib_30min_R2 2 NFETTQVCNESPHGDGYSSGVIK 23 0 Q92628 Q92628 KIAA0232 Uncharacterized protein KIAA0232 1 NFET(0.001)T(0.001)QVCNES(0.998)PHGDGYSSGVIK;NFETT(0.001)QVCNES(0.997)PHGDGY(0.002)SSGVIK 100.68 3.0353e-05 17272100.0 54777.0 39630.0 59368.0 67347.0 59045.0 41215.0 45918.0 48706.0 43670.0 53136.0 True False 51732.71362970485 42669.49356946574 55548.32751499105 58174.22241994494 51627.239231002655 46891.992137480855 48053.277984790875 48847.72639628763 52405.220241748946 51601.82561609196 1.0025364996693464 0.8268989141376292 1.0764798890694358 1.1273675247994208 1.0004924944923415 0.908727386630632 0.9312321300858302 0.9466278724265625 1.015569112450286 1.0 15.655134487071841 -6.557658884149077 22.122888670677465 0.9551970121364445 1.008192955972986 0.08055883342209669 0.07760443172414848 144.87403815713066 92148.60544800817 0.027745986534472335 0.027746331549376956 2.76911578867604e-07 6.557658884149077 0.052995943836541604 NFGEDMDDER ddPTM_A459_Selumetinib_30min_R1 2 NFGEDMDDER 10 0 P11940;E7ERJ7;P11940-2;A0A087WTT1;E7EQV3;Q9H361;H0YAR2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 ; 242.35 3.1364e-08 20343300.0 7952.0 9166.3 6542.6 7142.1 8096.9 6924.1 8541.8 7198.0 4612.799999999999 7127.6 False True 8137.266128101524 8093.105334702745 5654.150855929314 5894.866308821311 7364.536824623798 6854.4498405797885 7897.485148957366 7007.085657600851 7827.584694417788 8042.496888703313 1.011783559348506 1.0062926286077298 0.7030342608986611 0.7329646986996518 0.915702788143842 0.852278830248317 0.981969313541217 0.8712574906237358 0.9732779263381008 1.0 12.97342775742345 -7.2506136894767215 24.03635265417459 0.9458976403789805 0.8647347537103158 0.14882917853486388 0.09923423655350518 994.6581378840017 2208449.4558999455 0.04170351184887121 0.03194316885581664 5.615472574435295e-08 7.2506136894767215 -0.08116288666866467 NFGEDMDDER ddPTM_A459_Selumetinib_30min_R2 3 NFGEDMDDER 10 0 P11940;E7ERJ7;P11940-2;A0A087WTT1;E7EQV3;Q9H361;H0YAR2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 ;; 198.62 2.3599e-07 24874000.0 143286.0 100805.0 124945.0 134609.0 147271.0 101446.0 116007.0 125603.0 98196.0 115577.0 False True 135322.73773930463 108536.41936083745 116906.1747298302 116275.02198652284 128769.50036055529 115419.26566490074 121401.5553635095 125968.48393530388 117837.9438254816 112239.99170489048 1.2056552720986027 0.9670030949949575 1.041573265946138 1.0359500229850476 1.1472693324775487 1.0283256788575807 1.0816247713444889 1.1223137316911904 1.0498748443897756 1.0 16.776227281884722 -4.735841157915822 24.829793322924388 1.0587144149392012 1.2056560352010428 0.44290185390904546 0.05107223994301914 2362.3976397401166 2291351.076266046 0.012725416882192742 0.9533957870880216 1.8372101753532022e-05 4.735841157915822 0.14694162026184165 NFGEDMDDERLK ddPTM_A459_Selumetinib_30min_R2 1 NFGEDMDDERLK 12 1 P11940;E7ERJ7;P11940-2;A0A087WTT1;E7EQV3;Q9H361;H0YAR2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 109.6 0.021336 4831800.0 38744.0 37944.0 32998.0 41992.0 41733.0 22758.0 21514.0 26145.0 14526.0 32373.0 False True 36590.76358452059 40854.18279081017 30874.944605505894 36272.617159759546 36490.12744224634 25892.707923445112 22514.443629182242 26221.07762146224 17431.6058903514 31438.30737484464 1.1638910183122226 1.2995032558114004 0.9820803721198578 1.1537713124079663 1.1606899508668813 0.823603752413311 0.7161468128909882 0.8340486435488901 0.5544702417503334 1.0 14.940235925146824 -6.8072774904086595 4.506298223316074 0.764118472860836 1.152382910570483 0.6793317524720712 0.12590613622554583 0.11544049078137401 5.024417453008251 0.04326223312731406 0.03905178106378922 1.5585563523955089e-07 6.8072774904086595 0.388264437709647 NFHENCYR ddPTM_A459_Selumetinib_30min_R1 1 NFHENCYR 8 0 Q8WUP2-3;Q8WUP2 Q8WUP2-3 FBLIM1 Filamin-binding LIM protein 1 0 96.034 0.030075 1454900.0 1613.1 1703.5 2128.9 1832.5 1798.2 1684.9 1749.4 1428.3 1069.8 1300.5 False True 1650.6820914537934 1504.0534280643355 1839.8070732106366 1512.4882752852882 1635.5531274979949 1667.9514357667972 1617.4413495499803 1390.416844227744 1815.3724648994428 1467.4318429427371 1.124878200914308 1.0249562426341783 1.2537598131448142 1.0307042760174785 1.1145683769667374 1.136646614143213 1.1022258766760977 0.9475171544863371 1.2371085400865758 1.0 10.51907778143386 -14.522878745280336 0.3252510303925013 3.1059548638173993e-07 1.1076795892368245 0.10809881636408847 0.088707772651443 789.31301554625 6.9071645857033825 545.2906467651725 0.07268066200623345 3.0000000000000132e-15 14.522878745280336 1.107679278641338 NFHENCYR ddPTM_A459_Selumetinib_30min_R2 1 NFHENCYR 8 0 Q8WUP2-3;Q8WUP2 Q8WUP2-3 FBLIM1 Filamin-binding LIM protein 1 0 96.948 0.029036000000000006 1396200.0 11932.0 10512.0 13246.0 11459.0 16014.0 8563.0 10873.0 10432.0 9060.9 12964.0 False True 11268.86720758052 11318.236598592579 12393.766781154342 9898.264432122429 14002.178153023573 9742.475522825394 11378.616044440769 10462.355392889429 10873.333182698949 12589.69563548285 0.8950865480671588 0.8990079606605591 0.9844373636979513 0.7862195178273508 1.1121935397357643 0.7738451988757504 0.9038039023255836 0.8310252841539936 0.8636692655264437 1.0 13.619955784886974 NFILDQTNVSAAAQR ddPTM_A459_Selumetinib_30min_R2 1 NFILDQTNVSAAAQR 15 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;Q5RI18;A0A1W2PRZ7;A0A1W2PQ74;A0A1W2PQL0;A0A1W2PP34;A0A1W2PPL4;A0A1W2PPH7;A0A1W2PQD4 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 129.76 0.01185 2940100.0 13874.0 12599.0 10666.0 16134.0 14206.0 8453.6 9239.8 9933.8 8032.5 13648.0 False True 13102.93862202246 13565.302787829904 9979.761172262746 13936.521367297597 12421.315276748646 9618.006665859715 9669.469008316364 9962.705713370879 9639.224446802118 13253.946778237421 0.9886065517885653 1.023491569326634 0.752965236637981 1.0514997230999104 0.937178599294217 0.7256711398337732 0.7295539336398528 0.7516784154987961 0.7272720049419115 1.0 13.694134410887424 -6.746304932638202 17.697524317491116 0.7677352558537037 0.9494017178859134 0.36178666280869476 0.10735745740885494 7.561094295616266 8840.32273061016 0.03420373256110436 0.0338704668523444 1.7934739267944366e-07 6.746304932638202 0.1816664620322097 NFITAEELR ddPTM_A459_Selumetinib_30min_R2 3 NFITAEELR 9 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ;; 160.82 0.01266 22382200.0 110417.0 83444.0 102306.0 113909.0 115420.0 108795.0 107188.0 97308.0 95654.0 98067.0 False True 104280.46517427247 89843.88648525091 95723.74334235043 98394.39769601455 100919.90773210823 123780.52370732099 112172.45438899248 97591.15016979333 114787.47279606698 95235.550901334 1.0949741371508332 0.943386011158071 1.0051261575787198 1.033168777465814 1.0596873413024444 1.299730221916395 1.1778422377711182 1.0247344531129954 1.205300664611991 1.0 16.539212603659273 -6.535718334068296 24.99647147838683 1.1491565128631638 1.0169583229669077 0.3060282600073291 0.08733734827087768 265.1367703247236 516171.9680892134 0.028560933667856746 0.028575994485336643 2.9126055044068955e-07 6.535718334068296 -0.1321981898962561 NFMPALEETPFHSCTAGPNPT(ph)LGRPLSPKPSSPGSVLAR ddPTM_A459_Selumetinib_30min_R1 1 NFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLAR 39 2 Q15583;F8VWK5;F8VUY0;F8VVS9;Q15583-4;Q15583-2;Q15583-3 Q15583 TGIF1 Homeobox protein TGIF1 1 NFMPALEET(0.038)PFHS(0.126)CT(0.126)AGPNPT(0.56)LGRPLS(0.126)PKPS(0.006)S(0.016)PGS(0.004)VLAR 50.057 0.0061171 17313000.0 791.28 1112.2 996.37 1170.0 888.94 1095.4 1097.8 1155.8 564.41 1069.4 True False 809.7152844371441 981.9831069522482 861.0684266686466 965.6814636200744 808.535533955104 1084.3812705436223 1014.992062156149 1125.14442943249 957.7625471245972 1206.6679068381115 0.6710340764418596 0.8137973185392695 0.7135918853804146 0.8002876832537088 0.6700563836770529 0.8986575878901738 0.8411527781622868 0.9324391765591566 0.7937250520188833 1.0 10.236812964002125 -6.776102981258952 24.999815857283032 0.8857197712629883 0.7407766071148001 0.5816249626878425 0.06733297637225255 177.50293920948116 302620.9593157456 0.02183492354090362 0.01933833561965225 1.674545755444814e-07 6.776102981258952 -0.1449431641481882 NFQAATESVPNSGNIHNGSLEQTEEPETSSHSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 NFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSR 35 0 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 NFQAATESVPNSGNIHNGSLEQT(0.001)EEPET(0.077)S(0.06)S(0.085)HS(0.171)PS(0.606)R 91.176 2.2507e-09 17143000.0 6940.0 5938.6 9593.6 12983.0 12568.0 9105.1 6855.3 8996.0 7509.5 10109.0 True False 6554.302583021189 6394.071524391351 8976.358220721906 11214.693003075794 10989.095480654434 10359.244877131556 7174.085033519249 9022.176870632025 9011.609832961158 9817.126903663688 0.6676395902119964 0.6513180064938475 0.9143569507461483 1.1423599911793483 1.1193799966620963 1.0552216528102079 0.7307723638411894 0.9190241665578356 0.9179477785499629 1.0 13.261085149495464 -5.323206278677912 4.206461244886577 0.9809686536204666 0.6563747392792151 0.5691391146842963 0.11079927530441915 0.16532403090391826 5.890704054517582 0.033320227517845816 0.07708650182965232 4.751095075794104e-06 5.323206278677912 -0.3245939143412515 NFS(ph)CGSVEFDEADLESLR ddPTM_A459_Selumetinib_30min_R1 3 NFSCGSVEFDEADLESLR 18 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 NFS(0.639)CGS(0.361)VEFDEADLESLR;NFS(0.987)CGS(0.013)VEFDEADLESLR;NFS(0.995)CGS(0.005)VEFDEADLESLR 208.4 1.5711e-11 14702800.0 1419.7800000000002 2038.97 2260.95 2295.97 2330.7000000000003 2084.37 2333.52 2544.77 1586.56 1725.3300000000002 True False 1452.8581115890318 1800.2464445085634 1953.9254085093655 1895.021940194686 2119.8885965185073 2063.4031302565363 2157.5007076722695 2477.274433022077 2692.276442242345 1946.792911637365 0.7462828238711299 0.9247241623632441 1.003663716273757 0.9734070474916942 1.0889132500156675 1.0598986250268887 1.1082332870514138 1.272489959365296 1.3829290347980492 1.0 10.926883711481628 -5.328765426416853 0.4585969878599368 1.2161420489016728 0.6312932235333345 0.6179825692873909 0.10405574113426291 2.0977122205117364 0.4941914142499537 0.08178025128171332 0.6328562238069178 4.690666686684661e-06 5.328765426416853 -0.5848488253683383 NFS(ph)CGSVEFDEADLESLR ddPTM_A459_Selumetinib_30min_R2 1 NFSCGSVEFDEADLESLR 18 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 NFS(0.853)CGS(0.147)VEFDEADLESLR 134.04 0.0005679999999999999 0.0 2910.4 2165.5 2264.8 2912.0 4303.2 2228.3 2530.7 2751.5 2243.1 4518.5 True False 2748.651619254302 2331.5868868200364 2119.0852337277956 2515.38057651981 3762.5935449038957 2535.2280985065777 2648.382564486917 2759.506409464654 2691.782677450586 4388.039164527092 0.626396327880207 0.531350518853292 0.4829230447299742 0.5732356713800885 0.8574658073521088 0.5777587672875304 0.6035457900869348 0.6288700501519001 0.6134363383105048 1.0 12.099360686933927 -14.522878745208514 0.26387345920414373 3.5646684121881766 0.5808164501261968 0.6166704994563754 0.09248616991673353 143.88751181830708 1.4058713135835095 200.52632220503716 0.12739285877138254 3.0000000004961397e-15 14.522878745208514 -2.98385196206198 NFS(ph)DNQLQEGK ddPTM_A459_Selumetinib_30min_R1 2 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 NFS(1)DNQLQEGK;NFS(1)DNQLQEGK 152.0 0.00058593 24762000.0 5475.700000000001 6364.700000000001 8115.5 8049.900000000001 6697.7 6767.0 7048.2 8554.5 3694.1000000000004 6424.5 True False 5603.273156142541 5619.5179651312465 7013.459675250564 6644.136080337808 6091.8942175749735 6698.930123944402 6516.5485994616265 8327.606871067863 6268.617893610985 7249.147154929349 0.7729561886921236 0.7751971156096658 0.9674875575510259 0.9165403789354533 0.8403601261470524 0.9240990672108504 0.8989400353158009 1.14877056474225 0.8647386733415098 1.0 12.823595560103067 -2.588696731017296 0.2772084437213277 0.9998828697388681 4.484025377549282e-16 0.38813402452123136 0.08301213695548677 30.05616134266758 0.7140898337802426 0.09569208396471758 12.88960636650126 0.0025781208371523233 2.588696731017296 -0.9998828697388676 NFS(ph)DNQLQEGK ddPTM_A459_Selumetinib_30min_R2 4 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 NFS(1)DNQLQEGK;NFS(1)DNQLQEGK;NFS(1)DNQLQEGK;NFS(1)DNQLQEGK 154.13 0.0010349 26504800.0 118968.0 111616.0 123131.0 113575.0 112954.0 76034.0 95272.0 103266.0 67368.0 95140.0 True False 112356.23482663756 120176.58829799369 115208.88551489635 98105.88907219707 98763.70869842793 86506.99333206893 99702.33677788664 103566.48696339341 80843.48241919259 92393.06099659337 1.216067890972681 1.300710107466022 1.2469430525647833 1.0618317870842524 1.0689515817867474 0.9362931847799537 1.0791106572555569 1.1209336052543168 0.8749951733082355 1.0 16.495496884418948 -5.804372945081922 3.088180710987271 1.0212540220650306 1.2650111986429544 0.7069979274088216 0.06956965419215849 0.13435084562820698 2.612788897704608 0.01998365635338717 0.033664521229093136 1.5690148533065996e-06 5.804372945081922 0.24375717657792384 NFS(ph)IQVR ddPTM_A459_Selumetinib_30min_R1 1 NFSIQVR 7 0 I3L4X8;H3BM21;P05106-2;P05106-3;P05106 I3L4X8 ITGB3 Integrin beta;Integrin beta-3 1 NFS(1)IQVR 117.16 0.0078033 2058000.0 688.28 787.27 758.19 660.16 685.86 596.48 735.57 568.85 487.25 518.76 True False 704.3155848402557 695.0960624081061 655.2319624395568 544.8754487379726 623.8240840984176 590.479952760508 680.0853626891952 553.7622501147883 826.827662668025 585.3478991503074 1.2032426969715653 1.1874921963794685 1.119388936717281 0.9308574431187253 1.06573216544206 1.0087675271708505 1.1618481311309206 0.946039527806679 1.4125405829050557 1.0 9.193150529333204 -5.375731572806951 3.9983962658422194 1.0706673909656588 1.1954133058464356 0.1148279016963224 0.13032475392243756 0.45650866990069616 12.482002950272829 0.033176463010771574 0.07484876359610461 4.2098674998594895e-06 5.375731572806951 0.1247459148807768 NFSCGS(ph)VEFDEADLESLR ddPTM_A459_Selumetinib_30min_R1 1 NFSCGSVEFDEADLESLR 18 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 NFS(0.047)CGS(0.732)VEFDEADLES(0.22)LR 184.88 3.2579e-10 9281000.0 952.41 859.32 913.73 1054.4 1040.9 1187.7 1183.3 1039.9 790.57 913.68 True False 974.5992999327431 758.7104149129699 789.6504847596206 870.268833539322 946.7507787858215 1175.7528163453171 1094.042728319704 1012.3184739287472 1341.5395490517415 1030.9597279968627 0.9453320759932815 0.7359263357329499 0.7659372750610716 0.8441346542509858 0.9183198461353502 1.1404449508709569 1.0611886173724852 0.981918542924722 1.3012531068098363 1.0 10.009772262999562 -6.549082397603845 2.7935802106626464 1.0939519269014102 0.813149046667945 0.6362993929601306 0.09793031564369228 0.16959236871853528 2.6924359946978105 0.03333377304375802 0.034996030184864024 2.824344068356045e-07 6.549082397603845 -0.2808028802334652 NFSCGS(ph)VEFDEADLESLR ddPTM_A459_Selumetinib_30min_R2 1 NFSCGSVEFDEADLESLR 18 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 NFS(0.001)CGS(0.999)VEFDEADLESLR 164.56 2.6993e-06 0.0 4127.1 3475.8 4350.9 5012.8 5547.1 3846.2 5183.8 5978.9 3015.5 3926.3 True False 3897.7323040903066 3742.382683541486 4070.9678309017395 4330.047992437674 4850.223706296807 4375.979137672664 5424.85697150483 5996.29760913982 3618.684260109779 3812.9375172474784 1.0222387034823588 0.9814959376106103 1.0676723162881858 1.1356199709150998 1.2720438466031132 1.1476661020219499 1.4227500311678278 1.5726189013106326 0.9490541724696478 1.0 11.89668717442116 -5.929519659728777 1.4420018527068457 1.2677363349104203 0.9987240025052277 0.1976239584316647 0.17506752890323654 0.562273568060342 2.3743911711940835 0.06014813740324678 0.11518481333142311 1.1761977391269368e-06 5.929519659728777 -0.2690123324051925 NFSDNQLQEGK ddPTM_A459_Selumetinib_30min_R2 4 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 ;;; 169.65 0.005663800000000001 17470500.0 71845.0 77143.0 82057.0 81093.0 77158.0 60720.0 64986.0 72327.0 53195.7 76922.0 False True 67852.1425183223 83059.62004615943 76777.54195690624 70047.9935067723 67464.72223872809 69083.62883871983 68007.97776731596 72537.4595956205 63836.326412045 74701.06199264199 0.9083156344551795 1.1118934300337089 1.0277971946967606 0.9377108121123096 0.9031293590628381 0.924801160732153 0.9104017527088798 0.9710365242567154 0.8545571469697826 1.0 16.188841132880256 -5.793346782787143 5.3298066641030095 0.9248540693521561 1.0260577169492382 0.31106044087374407 0.05889999461252755 0.18137971195999775 13.200229579809575 0.015647927680384147 0.024495923766418903 1.6093600530049247e-06 5.793346782787143 0.10120364759708211 NFT(ph)PPSPFANK ddPTM_A459_Selumetinib_30min_R2 1 NFTPPSPFANK 11 0 Q9NPG3;Q9NPG3-2;K7EJT1 Q9NPG3 UBN1 Ubinuclein-1 1 NFT(0.739)PPS(0.261)PFANK 124.48 0.0083236 3524300.0 32242.0 31229.0 27588.0 31428.0 27798.0 23343.0 29596.0 22966.0 19198.0 27498.0 True False 30450.118714952332 33624.16388293833 25813.018115543262 27147.452183676036 24305.766722726938 26558.286363343825 30972.272643361448 23032.827257774017 23038.136436938323 26704.061291615788 1.1402804383358978 1.2591404549200622 0.9666326718493459 1.016603874864512 0.9101898942374792 0.9945410952034576 1.1598337910153667 0.8625215096029449 0.8627203250230538 1.0 14.704771550664601 -5.269738263484353 24.70749730003379 0.9736721215534998 1.1997104491591237 0.5311657088400195 0.08569488896678452 367.6812575175933 1094665.804171683 0.023215445673865912 0.04965276592579131 5.37355547192524e-06 5.269738263484353 0.22603832760562392 NFTKPQDGDVIAPLIT(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 NFTKPQDGDVIAPLITPQK 19 1 Q9Y3Z3-3;Q9Y3Z3-4;Q9Y3Z3 Q9Y3Z3-3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 NFTKPQDGDVIAPLIT(1)PQK;NFTKPQDGDVIAPLIT(1)PQK 126.96 0.00049592 11929800.0 104153.0 75429.0 95703.0 112510.0 126150.0 106202.0 122275.0 132470.0 104871.0 89697.0 True False 98364.5932174936 81214.1617575381 89545.57317354766 97185.94390942459 110301.90920469121 120830.3614942312 127961.02978331585 132855.46576841112 125848.13034056441 87107.21454920583 1.129235893106519 0.9323471331029782 1.0279926138949653 1.115704874876069 1.266277538267315 1.38714527975149 1.4690061029449195 1.525194743695571 1.4447497947425962 1.0 16.41050459278597 -6.335782690239566 1.7452319327439576 1.406344951758139 1.0207846035667916 0.5126496960290405 0.1433942714344642 0.24996469964165316 1.5072100160155602 0.04978692526657904 0.06255764499848214 4.615484637402656e-07 6.335782690239566 -0.38556034819134744 NFTKPQDGDVIAPLIT(ph)PQKK ddPTM_A459_Selumetinib_30min_R1 2 NFTKPQDGDVIAPLITPQKK 20 2 Q9Y3Z3-3;Q9Y3Z3-4;Q9Y3Z3 Q9Y3Z3-3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 NFTKPQDGDVIAPLIT(1)PQKK;NFTKPQDGDVIAPLIT(1)PQKK 129.29 0.00058661 87851000.0 11890.3 13012.3 14165.3 16088.1 10931.1 11953.5 10713.5 10810.8 7944.4 10418.9 True False 12167.320855503702 11488.813866745844 12241.730064423235 13278.61534603942 9942.383935042448 11833.25864290962 9905.372069511666 10524.062465572557 13481.066563981249 11756.267303680193 1.0349646313073224 0.9772501398593901 1.0412939539568884 1.1294924658511865 0.8457092441178226 1.0065489612681167 0.842560977361486 0.895187408870679 1.1467131714299421 1.0 13.52114244675695 -6.256515126559134 24.984750219656764 0.9477228329895501 1.0405391120680558 0.18615804230424693 0.09053517423474106 708.0633478340059 3592579.4713061545 0.026919684261316544 0.033667419277905834 5.539682487834479e-07 6.256515126559134 0.09281627907850576 NFTKPQDGDVIAPLIT(ph)PQKK ddPTM_A459_Selumetinib_30min_R2 4 NFTKPQDGDVIAPLITPQKK 20 2 Q9Y3Z3-3;Q9Y3Z3-4;Q9Y3Z3 Q9Y3Z3-3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 NFTKPQDGDVIAPLIT(1)PQKK;NFTKPQDGDVIAPLIT(1)PQKK;NFTKPQDGDVIAPLIT(1)PQKK;NFTKPQDGDVIAPLIT(1)PQKK 89.20100000000002 0.0024178 65559000.0 333108.0 336268.0 330809.0 338992.0 313140.0 266792.0 285377.0 278543.0 194126.0 296694.0 True False 314595.19089697686 362058.67432796146 309525.1090976066 292820.7048061825 273800.5536928812 303540.1763033553 298647.595963798 279353.51401472377 232956.62433363273 288127.6733164103 1.0918603800735969 1.2565911151837301 1.0742637301544393 1.0162880275808097 0.950275100414268 1.0534919218606942 1.036511323352947 0.9695476689181082 0.8085187432788141 1.0 18.136348705705245 -5.617129343278206 2.601384590665915 0.97758933264017 1.1745447331470618 0.534738362459699 0.0739991066713219 0.21308246377744217 2.8974993844690937 0.021551785913913296 0.04424101082800585 2.4147415595825397e-06 5.617129343278206 0.19695540050689175 NFTPPS(ph)PFANK ddPTM_A459_Selumetinib_30min_R2 1 NFTPPSPFANK 11 0 Q9NPG3;Q9NPG3-2;K7EJT1 Q9NPG3 UBN1 Ubinuclein-1 1 NFT(0.409)PPS(0.591)PFANK 111.31 0.008318700000000002 3859600.0 30212.0 35033.0 31827.0 34442.0 35223.0 26809.0 27988.0 27775.0 23635.0 29917.0 True False 28532.937988218466 37719.91845115049 29779.285470617502 29750.940184236035 30797.971842384737 30501.69640212847 29289.497457169866 27855.820651601232 28362.660417076622 29053.218476298985 0.9820921565538443 1.298304299123404 1.024990931552414 1.024015298288079 1.0600537034307949 1.049856022905384 1.0081326267196054 0.9587860523723193 0.9762312715960985 1.0 14.826410371840119 -6.234965091121444 0.6160767055702095 0.9785035660233321 1.1348774641662167 0.23945607091334453 0.08007180715102799 1.264991311598581 0.9962709946595869 0.05434093106708905 0.1098557557761228 5.821500094942195e-07 6.234965091121444 0.1563738981428846 NFVFHTLS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 NFVFHTLSPVK 11 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 NFVFHT(0.058)LS(0.942)PVK;NFVFHT(0.033)LS(0.967)PVK 82.48299999999998 0.026395 25950000.0 106655.0 89194.0 86654.0 93646.0 107134.0 90421.0 112421.0 108234.0 80987.0 91770.0 True False 100727.5420737931 96034.89299608719 81078.77598174167 80891.2532516396 93674.86912988812 102875.67198988612 117648.7992579854 108548.94302089677 97186.66296584684 89120.36165290499 1.1302416216183495 1.077586437206259 0.9097671337726085 0.9076629824134342 1.0511051278575536 1.1543453155021253 1.3201113311926342 1.2180038434276088 1.0905101950142155 1.0 16.443467466735854 -6.717256063666548 3.684625824383569 1.1824205078049705 1.0026180724736227 0.3207407689629498 0.10108405894147691 0.242811758708785 6.823803177456532 0.037057778521636574 0.03558124911820393 1.917537810935149e-07 6.717256063666548 -0.17980243533134788 NFYES(ph)DDDQK ddPTM_A459_Selumetinib_30min_R2 2 NFYESDDDQK 10 0 O00203-3;O00203 O00203-3 AP3B1 AP-3 complex subunit beta-1 1 NFYES(1)DDDQK;NFYES(1)DDDQK 127.79 0.0032270000000000003 8756000.0 53672.0 33891.0 38853.0 40208.0 47449.0 41908.0 72168.0 69398.0 44952.0 31350.0 True False 50689.12510603937 36490.33072325925 36353.240279947895 34731.60103733121 41488.03242055799 47680.44659705322 75523.95499817902 69599.93669054264 53943.65606382185 30444.844042917848 1.6649494093181534 1.1985717736579347 1.194068861995188 1.140804038554783 1.362727703977483 1.5661254999315641 2.4806812901295707 2.286099301163382 1.7718486581103166 1.0 14.893910302145896 -7.023295666248114 5.460667114014157 1.9993897820829936 1.302560691633262 0.30262655392586946 0.3937468082370653 0.1809304354654432 16.423573331246025 0.14414366128554792 0.1163174612950636 9.477730028838076e-08 7.023295666248114 -0.6968290904497316 NFYES(ph)DDDQKEK ddPTM_A459_Selumetinib_30min_R1 4 NFYESDDDQKEK 12 1 O00203-3;O00203 O00203-3 AP3B1 AP-3 complex subunit beta-1 1 NFYES(1)DDDQKEK;NFYES(1)DDDQKEK;NFYES(1)DDDQKEK;NFYES(1)DDDQKEK 153.94 0.0021625 94026000.0 8189.1 10654.800000000001 7970.9 6856.04 5712.540000000001 8358.22 8668.2 9379.300000000001 5835.32 10021.3 True False 8379.890096785233 9407.331062717867 6888.495561019621 5658.761317810064 5195.841765630852 8274.143895456562 8014.350695192139 9130.530495739882 9902.111845089752 11307.631470728227 0.7410827031706895 0.8319453182631907 0.609189959794117 0.5004373667870899 0.45949868273308986 0.7317309479775339 0.7087559155017283 0.8074662248567129 0.8757016772896333 1.0 13.465009149435643 -8.07571068019557 1.1077284352629193 0.9857683423819255 0.6376868857259461 0.5665172901320124 0.1044023013296124 0.4049690235172179 0.9292521125883362 0.11019080279829867 0.03832912835642889 8.400194072028424e-09 8.07571068019557 -0.34808145665597934 NFYES(ph)DDDQKEK ddPTM_A459_Selumetinib_30min_R2 3 NFYESDDDQKEK 12 1 O00203-3;O00203 O00203-3 AP3B1 AP-3 complex subunit beta-1 1 NFY(0.002)ES(0.998)DDDQKEK;NFY(0.001)ES(0.999)DDDQKEK;NFYES(1)DDDQKEK 172.57 0.0010409 213304000.0 243522.0 163438.0 172403.0 162110.0 141830.0 122775.0 238436.0 214058.0 127789.0 125655.0 True False 229988.0221358048 175973.1690640005 161310.77867819337 140030.3383446518 124012.04742371263 139686.1418095163 249523.7464519707 214680.87334079068 153350.37072298749 122027.01365910203 1.8847303989451512 1.4420837139848717 1.3219267917908368 1.1475355672953231 1.0162671666304648 1.14471490878034 2.0448238383432624 1.7592897417003828 1.256691990770103 1.0 16.896841033355713 -4.76504143611848 3.555642408873137 1.364354780786992 1.9560154580209723 0.21109893626075937 0.31331990055917697 0.5636891816128402 11.680241072889151 0.0871141013113235 0.9215413214491602 1.71774448901306e-05 4.76504143611848 0.5916606772339803 NFYQEHPDLAR ddPTM_A459_Selumetinib_30min_R2 2 NFYQEHPDLAR 11 0 P17844-2;P17844;J3KTA4;J3QR02;J3KRX8;J3QRQ7;J3KTQ4;X6RLV5 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 0 ; 156.01 0.00076114 30121400.0 131393.0 115491.0 129930.0 146321.0 152901.0 113380.0 117816.0 108591.0 91730.0 130017.0 False True 124090.70306785346 124348.7883379049 121570.44525708779 126391.82738219622 133692.20942771685 128997.06583883484 123294.67744797507 108906.98183179219 110078.56315034664 126263.07138526498 0.982794903580454 0.9848389317133032 0.9628345320869105 1.0010197439007196 1.0588385658684274 1.0216531597368455 0.9764904028967228 0.862540255333134 0.8718191466645482 1.0 16.946073225046014 -7.614396127992088 5.581487991593472 0.9012752195160484 1.001757694784432 0.4714523616925257 0.04241351551371834 0.1656940512668207 8.03819931809395 0.020814861758501897 0.01179038872208384 2.4299865624621533e-08 7.614396127992088 0.10048247526838361 NFYVEHPEVAR ddPTM_A459_Selumetinib_30min_R2 1 NFYVEHPEVAR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 121.68 0.005629100000000001 0.0 19597.0 16893.0 17827.0 18426.0 19403.0 10007.0 13552.0 9575.2 11202.0 15962.0 False True 18507.877193006665 18188.638780443718 16680.030228570035 15916.347013377066 16965.421674979156 11385.373415498512 14182.194852778553 9603.062246740303 13442.713010031412 15501.135585743386 1.1939691186256458 1.1733746008371198 1.0760521470382398 1.026785871611597 1.0944631495632162 0.7344864092389335 0.9149132832450106 0.6195070157035705 0.8672082723019896 1.0 13.920086288204407 -6.750587664151333 24.56027390163244 0.8089228360824974 1.1094527266681218 0.6437659787169656 0.10581300309601077 102.6503939206609 232324.18718381718 0.034224618980936816 0.033888287372007615 1.7758747643837755e-07 6.750587664151333 0.3005298905856244 NGAAGPHS(ph)PDPLLDEQAFGDLTDLPVVPK ddPTM_A459_Selumetinib_30min_R2 1 NGAAGPHSPDPLLDEQAFGDLTDLPVVPK 29 0 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 NGAAGPHS(1)PDPLLDEQAFGDLTDLPVVPK 98.133 8.605600000000001e-08 3692000.0 16702.0 15332.0 14322.0 15380.0 16056.0 12786.0 17574.0 31825.0 28385.0 37365.0 True False 15773.769703403426 16507.915099849826 13400.538112614568 13285.217468020146 14038.901737538801 14547.15544024822 18391.225822220356 31917.605481087627 34062.79314316563 36286.17536407102 0.43470466493478727 0.4549367612932621 0.3693014757869244 0.36612338816988094 0.3868939505660744 0.40090076439007055 0.5068383657879397 0.8796078716163357 0.9387264654211288 1.0 15.147132381418489 -7.748452902561939 2.5249295890402768 0.9656879371545604 0.400879622739232 0.9853346639729524 0.029566222525319093 0.0343977553768499 0.43924487069891666 0.021442313596563824 0.009557928200046115 1.784625513293117e-08 7.748452902561939 -0.5648083144153284 down NGDECAYHHPIS(ph)PCK ddPTM_A459_Selumetinib_30min_R1 2 NGDECAYHHPISPCK 15 0 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V5I6;G3V411;Q6PJT7-8;H0YJ51;Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11;Q6PJT7-6 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 NGDECAYHHPIS(1)PCK;NGDECAY(0.001)HHPIS(0.999)PCK 93.812 0.0079956 65963000.0 18001.3 21290.2 20097.4 19518.3 16124.3 18796.5 18197.9 17000.0 11769.2 16835.1 True False 18420.69526556764 18797.533486454537 17368.283467116096 16109.795308868124 14665.859911976377 18607.4242758565 16825.217751786666 16549.104776217624 19971.472811641914 18996.0490727607 0.9697119224640198 0.9895496381618205 0.9143103074007779 0.8480603122871847 0.7720479061620462 0.9795418091722312 0.885721956567964 0.871186672177434 1.0513487691648427 1.0 14.213411767797538 -10.158430289494481 7.193024499685566 1.0000057820623518 0.914848720080059 0.08499632328539197 0.0768215164436486 1.1227871501991355e-10 0.0 0.07654272644405029 0.018564338000092794 6.943360436830598e-11 10.158430289494481 -0.08515706198229278 NGDECAYHHPIS(ph)PCK ddPTM_A459_Selumetinib_30min_R2 3 NGDECAYHHPISPCK 15 0 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V5I6;G3V411;Q6PJT7-8;H0YJ51;Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11;Q6PJT7-6 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 NGDECAYHHPIS(1)PCK;NGDECAY(0.007)HHPIS(0.993)PCK;NGDECAYHHPIS(1)PCK 92.096 0.0072225 83949300.0 423762.0 394813.0 381827.0 412408.0 385960.0 322029.0 404809.0 390622.0 292803.0 426236.0 True False 400211.0044936925 425093.88757611584 357260.666521804 356237.3189565189 337472.2542738216 366385.57166179374 423633.420613816 391758.64534904656 351371.7815993769 413929.45918587345 0.9668579889936736 1.0269718140192314 0.8630955313605198 0.8606232560909657 0.8152892885120335 0.8851401211752598 1.0234435148612726 0.946438183258488 0.8488687475650162 1.0 18.659025402659417 -9.842215947737614 16.053643011175975 0.9999949718233225 0.9156231484345324 0.11701178914701127 0.06988184254443906 0.0 0.0 0.07374285235362103 0.0178852687875475 1.438083330707568e-10 9.842215947737614 -0.08437182338879012 NGHDGDTHQEDDGEKS(ph)D ddPTM_A459_Selumetinib_30min_R1 1 NGHDGDTHQEDDGEKSD 17 1 K7EQH5;Q08117;Q08117-2 K7EQH5 AES Amino-terminal enhancer of split 1 NGHDGDTHQEDDGEKS(1)D 95.957 0.0034019 1638300.0 403.62 741.92 733.55 529.34 315.67 638.18 538.12 765.9 800.17 833.56 True False 413.0235606921952 655.0556614907497 633.9379391017254 436.90070594243605 287.1177042360652 631.7604886210786 497.52917515710277 745.5858440061808 1357.8300478954818 940.5555455619747 0.4391272398967323 0.696456115305087 0.6740037226859924 0.464513454844808 0.30526395340587203 0.6716886542236127 0.5289737299457768 0.7927079347139451 1.4436468471239399 1.0 9.877369336011784 -8.044273842294048 4.01642100023623 1.2146307670325769 0.547792298229454 0.7565086061809387 0.1530202325086835 0.10553944726609328 3.5285379051650003 0.10856872907660006 0.039992288975487685 9.030798615005194e-09 8.044273842294048 -0.6668384688031229 NGIDILVGT(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 NGIDILVGTPGR 12 0 Q9NR30;Q9NR30-2;A0A087WVC1;Q9BQ39 Q9NR30;A0A087WVC1 DDX21;DDX50 Nucleolar RNA helicase 2;ATP-dependent RNA helicase DDX50 1 NGIDILVGT(1)PGR 105.17 0.022064 3396800.0 18147.0 15694.0 18083.0 17897.0 20310.0 16705.0 19136.0 18105.0 14125.0 19813.0 True False 17138.46238819676 16897.679335836376 16919.559467281753 15459.397725952973 17758.476226296294 19005.962117108294 20025.86191726464 18157.6825525559 16950.394685475247 19240.947209643742 0.8907286216973145 0.8782145261209958 0.8793516911060133 0.8034634447832474 0.9229522867458199 0.9877872388518549 1.0407939743853927 0.9437000348639333 0.8809542742770767 1.0 14.231892202618875 -6.513932604254725 5.778740170931155 0.9703114547971563 0.8646159941448067 0.5665366793459157 0.04438036499982718 0.13087559091616416 16.167369424257497 0.015228146255536144 0.016223577081034994 3.062438639637871e-07 6.513932604254725 -0.10569546065234958 NGIGPGSHSEFAAS(ph)IGSPK ddPTM_A459_Selumetinib_30min_R1 1 NGIGPGSHSEFAASIGSPK 19 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 NGIGPGSHSEFAAS(0.735)IGS(0.265)PK 106.88 0.00053171 46898000.0 9649.9 10398.0 12043.0 11561.0 8225.3 9050.3 9237.4 9137.2 6057.1 9657.3 True False 9874.723894563242 9180.597326100948 10407.6267474638 9542.088376847592 7481.323067294657 8959.26219901493 8540.615480926588 8894.851774191518 10278.45630691944 10896.908525067982 0.9061949884085713 0.8424955853287457 0.9550990286393058 0.8756693106945268 0.6865546361230911 0.8221838495206635 0.7837649973182009 0.8162729597783814 0.9432451674962845 1.0 13.411631277106054 -8.42374266946218 3.590976343102144 0.9981280371871978 0.8345347082884949 0.39762742853678235 0.06828043358382135 0.23870468289806512 5.503646701167861 0.07089175371866804 0.018766168845327832 3.769270717166763e-09 8.42374266946218 -0.16359332889870293 NGIGPGSHSEFAASIGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 NGIGPGSHSEFAASIGSPK 19 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 NGIGPGSHSEFAAS(0.114)IGS(0.886)PK 112.86 0.00036686 53959000.0 3602.3 3298.9 4204.7 4211.7 2836.4 3241.2 3364.3 3534.4 2091.4 3489.5 True False 3686.2265811443804 2912.663254382997 3633.724834763851 3476.2056584005727 2579.8481208070916 3208.596470774138 3110.52814238653 3440.656230650797 3548.953050187599 3937.411315608368 0.9362056147224799 0.7397406623069458 0.9228715375402443 0.8828657663019555 0.6552142801490578 0.8148999973802278 0.7899931942736146 0.8738371368547719 0.9013417105089138 1.0 11.943031713946668 -8.462504566180103 1.4990322831752807 0.9970976948777384 0.8178239559704985 0.3221508617737473 0.08000523046932075 0.46999254549834957 2.3049763383897592 0.0762291214173899 0.02263876881609627 3.447429819200957e-09 8.462504566180103 -0.17927373890723985 NGIGPGSHSEFAASIGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 NGIGPGSHSEFAASIGSPK 19 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 NGIGPGSHSEFAAS(0.023)IGS(0.977)PK;NGIGPGSHSEFAAS(0.007)IGS(0.993)PK;NGIGPGSHSEFAAS(0.019)IGS(0.981)PK;NGIGPGSHSEFAASIGS(1)PK 218.87 2.4470999999999997e-19 105589000.0 473549.0 429958.0 412078.0 397990.0 372508.0 292660.0 400536.0 361789.0 215015.0 338342.0 True False 447231.0423468447 462934.3960671294 385565.3501166024 343783.07542895636 325710.21477622696 332971.2584970311 419161.71764702746 362841.74609260645 258024.00802105942 328573.1873419117 1.3611306691360003 1.4089232289833864 1.1734534799864387 1.0462907159591732 0.9912866518755057 1.0133853623014673 1.2757027468916682 1.1042950553206128 0.7852862557301757 1.0 18.325855230844326 -5.451472134456387 2.6990028634604406 1.0432155277130923 1.388758132671733 0.5977217758912696 0.11497437558538574 0.20188991315825222 2.849632421899847 0.03346067661249044 0.08096871813470169 3.536127091488623e-06 5.451472134456387 0.34554260495864075 NGIGPGSHSEFAASIGS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 NGIGPGSHSEFAASIGSPKR 20 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 NGIGPGSHSEFAAS(0.001)IGS(0.999)PKR 103.71 0.00029043 4483100.0 11445.0 13730.0 13647.0 12421.0 16178.0 10647.0 10080.0 10382.0 7778.4 11690.0 True False 10808.932717965048 14783.04685109172 12768.966877730138 10729.23837257986 14145.575006844967 12113.527606156958 10548.739973141079 10412.209901167382 9334.297346654908 11352.479325732374 0.9521208898803909 1.302186634912725 1.1247734095218342 0.945100895119903 1.2460339808575167 1.0670380679486935 0.929201425562654 0.9171749714237569 0.8222254433440892 1.0 13.470719788988152 -7.222016925633511 3.451639849310635 0.9065707879491037 1.1186444135862288 0.41137279911066094 0.11153489480900655 0.2322424000972675 5.735475640769016 0.046161854196356704 0.03313016226684968 5.997677012264839e-08 7.222016925633511 0.21207362563712506 NGIS(ph)PTNPTK ddPTM_A459_Selumetinib_30min_R2 1 NGISPTNPTK 10 0 Q9UJF2-2;Q9UJF2;A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8 Q9UJF2-2;A0A3B3ITG3 RASAL2;DAB2IP Ras GTPase-activating protein nGAP;Disabled homolog 2-interacting protein 1 NGIS(0.702)PT(0.187)NPT(0.111)K 81.92 0.043907 5036000.0 41224.0 50226.0 67248.0 85400.0 88734.0 53967.0 42706.0 47178.0 48059.0 59282.0 True False 38932.93511274719 54078.17269795572 62921.336894086286 73768.37267678292 77586.44162797506 61400.46438635036 44691.91362033359 47315.280169261634 57672.14288065519 57570.374626866236 0.6762668362866349 0.9393402952205071 1.0929464555668 1.2813599556178257 1.347679985250052 1.0665288316136254 0.7763005523239607 0.8218685474244095 1.001767719151535 1.0 15.81303897986302 -7.16449056541356 7.5240084628151465 0.8856446926162163 1.086255873620356 0.1598710555960332 0.18408688321612013 0.4984908555096411 34.07823640989761 0.0779993031298161 0.06034373373874722 6.847143576218836e-08 7.16449056541356 0.20061118100413977 NGISPT(ph)NPTK ddPTM_A459_Selumetinib_30min_R1 1 NGISPTNPTK 10 0 Q9UJF2-2;Q9UJF2;A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8 Q9UJF2-2;A0A3B3ITG3 RASAL2;DAB2IP Ras GTPase-activating protein nGAP;Disabled homolog 2-interacting protein 1 NGIS(0.083)PT(0.813)NPT(0.103)K 117.86 0.01378 10802000.0 2194.4 2364.6 3108.2 3252.6 2496.0 2280.2 2289.2 2369.4 1624.8 2148.3 True False 2245.525250440892 2087.751532727284 2686.123512120484 2684.594468863808 2270.2372407045923 2257.2632582559513 2116.5238009545055 2306.5558151041196 2757.1669293032487 2424.0552312140603 0.9263506959436094 0.861264011580156 1.1081115139340987 1.1074807348837754 0.9365451791160592 0.9311929980759667 0.8731334887507777 0.9515277479667439 1.1374191865761876 1.0 11.243206855127596 -8.239709337295597 24.111889451593743 1.068709607364454 0.963484892642302 0.19971863593152483 0.08543805131168718 783.9031510299945 869831.5428654476 0.06276586294542931 0.023665743097028992 5.758251941594957e-09 8.239709337295597 -0.105224714722152 NGLVNS(ph)EVHNEDGR ddPTM_A459_Selumetinib_30min_R1 2 NGLVNSEVHNEDGR 14 0 F2Z3N7;C9JZ87;Q9NUM4 F2Z3N7 TMEM106B Transmembrane protein 106B 1 NGLVNS(1)EVHNEDGR;NGLVNS(1)EVHNEDGR 84.436 0.017115000000000002 8759800.0 4039.8 2791.5 4181.4 2722.1000000000004 3457.2 3217.7 3408.0 5283.8 1771.54 3392.1 True False 4133.919479917568 2464.669882266857 3613.5888467861146 2246.736335145474 3144.4968704182347 3185.3328594378463 3150.931816203457 5143.656459798746 3006.1739918376875 3827.509076852028 1.0800547815597998 0.6439357380424421 0.9441098046351717 0.5869969972725249 0.8215517735635147 0.8322208505531891 0.8232330094942508 1.343865254534993 0.785412635601153 1.0 11.902190083710176 -7.569574450590363 24.99985783066475 1.0554937995757467 0.807443531081617 0.24135388721652662 0.18119616109444067 150.77168877074925 80718.19424029857 0.07855110034516727 0.04535151335836059 2.694173433788869e-08 7.569574450590363 -0.2480502684941297 NGLVNS(ph)EVHNEDGR ddPTM_A459_Selumetinib_30min_R2 2 NGLVNSEVHNEDGR 14 0 F2Z3N7;C9JZ87;Q9NUM4 F2Z3N7 TMEM106B Transmembrane protein 106B 1 NGLVNS(1)EVHNEDGR;NGLVNS(1)EVHNEDGR 117.27 0.0016726 5736800.0 103892.0 36015.0 75288.0 87358.0 65672.0 48141.0 92280.0 78906.0 62326.0 52918.0 True False 98118.09855262785 38777.23469352279 70444.05204737632 75459.68969904463 57421.69624487091 54771.98576951275 96571.202849351 79135.60339640857 74792.94153394188 51390.119842523985 1.909279426732095 0.7545659518278772 1.3707703399649538 1.4683695996482908 1.1173684050714345 1.0658077065660072 1.8791783935370558 1.539899179821058 1.4553953515409526 1.0 15.649203396082738 -7.233085418824813 24.993615739421408 1.5136100613993844 1.2622526882199172 0.058645812887665016 0.3452169607310858 1621.3144113804524 1429167.4924743297 0.12584210318885525 0.09745806727681454 5.846750765361347e-08 7.233085418824813 -0.25135737317946716 NGPCQS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 NGPCQSLR 8 0 Q8N9L1-5 Q8N9L1-5 1 NGPCQS(1)LR 93.598 0.023839 12913000.0 0.0 0.0 0.0 2786.4 2378.0 0.0 0.0 4161.0 0.0 0.0 True False 0.0 0.0 0.0 2406.8875131918953 2079.2543804102697 0.0 0.0 4173.107821109367 0.0 0.0 0.0 NGPSSS(ph)PFSSPASSR ddPTM_A459_Selumetinib_30min_R1 2 NGPSSSPFSSPASSR 15 0 Q96HA1;Q96HA1-2;Q96HA1-3;A6NF01;C9JFL1;A8CG34-2;A8CG34 Q96HA1;A8CG34-2 POM121;POM121B;POM121C Nuclear envelope pore membrane protein POM 121;Putative nuclear envelope pore membrane protein POM 121B;Nuclear envelope pore membrane protein POM 121C 1 NGPSS(0.011)S(0.989)PFS(0.001)SPASSR;NGPS(0.001)S(0.391)S(0.608)PFS(0.001)SPASSR 174.18 2.7291e-05 18413700.0 4785.1 5282.2 5344.5 5426.5 4260.5 4631.2 4785.9 4656.8 2826.0 4442.0 True False 4896.583519816218 4663.757568371842 4618.746255237092 4478.863643020798 3875.138527252368 4584.614332793157 4424.895709849803 4533.286536581781 4795.515597126406 5012.173968744055 0.9769380612786667 0.9304859722457881 0.9215055750338315 0.8935970042043666 0.7731452562137215 0.9146957710133043 0.8828296338960854 0.9044551455818136 0.9567735731104443 1.0 12.29122077503785 -9.937558091905693 7.445850579909691 1.0000051774814294 0.9024703628210978 0.22489023862626312 0.051946480493044636 0.0 0.0 0.05296622199263109 0.01284619575679595 1.1546275295845699e-10 9.937558091905693 -0.09753481466033154 NGPSSS(ph)PFSSPASSR ddPTM_A459_Selumetinib_30min_R2 2 NGPSSSPFSSPASSR 15 0 Q96HA1;Q96HA1-2;Q96HA1-3;A6NF01;C9JFL1;A8CG34-2;A8CG34 Q96HA1;A8CG34-2 POM121;POM121B;POM121C Nuclear envelope pore membrane protein POM 121;Putative nuclear envelope pore membrane protein POM 121B;Nuclear envelope pore membrane protein POM 121C 1 NGPS(0.001)S(0.082)S(0.917)PFSSPASSR;NGPS(0.016)S(0.058)S(0.924)PFS(0.003)SPASSR 160.63 0.00012734 14634600.0 52666.0 40653.0 48493.0 51825.0 38078.0 32062.0 46811.0 35027.0 30168.0 43611.0 True False 49739.03455870227 43770.95438000227 45373.013175186315 44766.34559688846 33294.30121836091 36478.24947014225 48987.80425423679 35128.922770968005 36202.44296434812 42351.83711501409 1.174424486560687 1.0335078089088394 1.0713351832169093 1.0570107142062655 0.786135938517713 0.8613144542249478 1.1566866419796982 0.8294545210770681 0.8548021864089113 1.0 15.37013693090706 -6.0852820231045 8.477025414989752 0.9156962351102879 1.083401926596445 0.39376830484563097 0.10344133872181273 0.38025434607438297 34.80990897272254 0.031353468421446484 0.04059012261172612 8.217088735403611e-07 6.0852820231045 0.1677056914861571 NGQYQAS(ph)DAAGLGLDR ddPTM_A459_Selumetinib_30min_R2 1 NGQYQASDAAGLGLDR 16 0 Q8TDX6-3;Q8TDX6 Q8TDX6-3 CSGALNACT1 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 1 NGQYQAS(1)DAAGLGLDR 71.98 0.038526 45359000.0 267380.0 218650.0 226810.0 255070.0 225740.0 188680.0 202200.0 192950.0 133730.0 213820.0 True False 252520.0900069457 235419.75192943888 212217.2915320566 220329.02597970737 197380.52305879464 214668.95733349244 211602.70065169877 193511.4525554081 160479.7367283966 207646.4610289222 1.216105917508381 1.1337527774992913 1.0220125615456443 1.0610776840979663 0.9505604963395082 1.0338194846652942 1.0190527669153269 0.931927525258688 0.7728508154350102 1.0 17.663769758193105 -1.5228787452803385 0.3121516205516018 0.9162758368605942 3.7430986478153776 0.635037697902411 0.06807982102072198 36.617388846162925 0.5228561557359949 0.06786524102266915 58.59059801408136 0.029999999999999933 1.5228787452803385 2.8268228109547833 NGS(ph)EADIDEGLYSR ddPTM_A459_Selumetinib_30min_R1 2 NGSEADIDEGLYSR 14 0 P22314;Q5JRR9;P22314-2;Q5JRS2;Q5JRS0;Q5JRS1;Q5JRS3 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 NGS(1)EADIDEGLYSR;NGS(0.984)EADIDEGLY(0.015)S(0.001)R 144.17 0.00053194 19228900.0 5325.7 4791.6 5914.9 5896.5 4325.4 4907.7 4853.8 4729.1 3264.88 4767.7 True False 5449.778447991731 4230.597244445593 5111.689068220015 4866.786966013477 3934.168333711392 4858.332993835072 4487.673958183201 4603.668905718281 5540.262902599454 5379.680736330715 1.0130300876755796 0.7864030324095272 0.9501844660964978 0.9046609277659357 0.7313014519881611 0.9030894642176784 0.8341896439832376 0.85575132268133 1.0298497576602037 1.0 12.393304841499827 -8.260850267012518 24.997084120563088 1.0149248949589513 0.868188670110174 0.36065196900079843 0.07578506882585127 52.5258856215945 2229032.573062145 0.05647410885520202 0.018371158822159974 5.484660285748165e-09 8.260850267012518 -0.14673622484877735 NGS(ph)EADIDEGLYSR ddPTM_A459_Selumetinib_30min_R2 3 NGSEADIDEGLYSR 14 0 P22314;Q5JRR9;P22314-2;Q5JRS2;Q5JRS0;Q5JRS1;Q5JRS3 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 NGS(1)EADIDEGLYSR;NGS(1)EADIDEGLYSR;NGS(0.875)EADIDEGLY(0.017)S(0.108)R 178.02 7.1045e-05 28696000.0 73902.0 67602.0 74755.0 73032.0 65585.0 38112.2 58179.0 60700.0 42832.0 58808.0 True False 69794.82269314579 72786.85602530985 69945.34468708996 63084.91561277291 57345.62596266086 43361.8096018949 60884.438779501485 60876.62695057404 51399.59682607258 57110.06023846616 1.2221108225365849 1.274501475245944 1.2247464701495563 1.1046200152715373 1.0041247675665388 0.759267446415488 1.0660895562931505 1.0659527707794454 0.9000095011535755 1.0 15.801457285868286 -6.002618382755498 2.2158022672409174 0.9633126475684692 1.2479346553103898 0.6845600198820913 0.08409781947395381 0.18529236025044363 1.8248109407015205 0.02785168306818949 0.043203536216807906 9.939890891455328e-07 6.002618382755498 0.2846220077419206 NGS(ph)LTNHFSFEK ddPTM_A459_Selumetinib_30min_R1 2 NGSLTNHFSFEK 12 0 A0A140TA71;P22102 A0A140TA71 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 NGS(0.992)LT(0.008)NHFSFEK;NGS(0.992)LT(0.008)NHFSFEK 106.88 0.0087155 25860000.0 5945.6 7328.7 6701.2 5992.0 3591.8 7380.0 5691.1 4901.700000000001 3116.2 4017.1 True False 6084.120911876312 6470.652396979803 5791.213847056751 4945.609683770499 3266.922324183793 7305.763900503864 5261.815745069106 4771.690993034466 5287.963801757003 4532.733914867566 1.3422629755345064 1.4275385492529749 1.2776425785906635 1.0910875812826077 0.7207399299279722 1.61177868317852 1.1608481424003556 1.0527180908155915 1.1666168588480894 1.0 12.146165757827692 -5.574314276850324 3.982813852433687 1.124170797542654 1.3805830240752526 0.22091424377693314 0.20724262384803852 0.3406118905375181 11.232980513717385 0.058366461443217166 0.11020534946570525 2.6649294925134434e-06 5.574314276850324 0.25641222653259854 NGS(ph)PNKQPSSEPEWTPEPR ddPTM_A459_Selumetinib_30min_R2 1 NGSPNKQPSSEPEWTPEPR 19 1 Q5JSZ5;A0A494C0D3 Q5JSZ5 PRRC2B Protein PRRC2B 1 NGS(0.968)PNKQPS(0.027)S(0.004)EPEWT(0.001)PEPR 57.708 0.026994 19065000.0 15014.0 11494.0 10826.0 13086.0 11167.0 8878.0 9697.4 8704.5 6576.4 11840.0 True False 14179.581985804041 12375.552840964907 10129.466946457565 11303.664225390874 9764.10162575335 10100.863913540103 10148.348315033561 8729.828653892448 7891.863759968807 11498.148435985571 1.2332056821797874 1.0763083212800886 0.8809650530128429 0.9830856062019496 0.8491890394452377 0.8784774322383585 0.8826071755407539 0.7592377766293956 0.6863595303109644 1.0 13.489113940085446 -1.5228787476978938 0.4903547409149981 0.8216395994393298 13.467407903044649 0.674909327697478 0.08512806167599175 58.01805017774759 0.6328302543369868 0.047594493072549406 752.0157648318701 0.029999999833001133 1.5228787476978938 12.645768303605319 NGS(ph)PPPGAPSSR ddPTM_A459_Selumetinib_30min_R1 4 NGSPPPGAPSSR 12 0 Q9Y3Q8 Q9Y3Q8 TSC22D4 TSC22 domain family protein 4 1 NGS(1)PPPGAPSSR;NGS(0.984)PPPGAPS(0.013)S(0.004)R;NGS(0.994)PPPGAPS(0.005)S(0.001)R;NGS(1)PPPGAPSSR 116.79 0.0049262 34794400.0 5445.120000000001 6362.799999999999 7323.5 7350.7 5681.22 5188.61 5924.049999999999 5330.2 3819.98 5135.5599999999995 True False 5571.980701640862 5617.840418014531 6329.008925105973 6067.038234728272 5167.354654100857 5136.417294280945 5477.194139019979 5188.825781070306 6482.227059699544 5794.759150590545 0.9615551840619676 0.9694691827600834 1.0921953373094 1.0469871269990538 0.8917289778254635 0.8863901261120561 0.9451978929032447 0.8954342443277409 1.1186361488447607 1.0 12.500532983949128 -5.007747015809382 23.926044202733785 0.9785704023401135 0.9635336114228412 0.005164846281300983 0.0785729029196702 2449.3549549077734 7565007.49675338 0.020949747620066145 0.06908548280431796 9.823199951001944e-06 5.007747015809382 -0.01503679091727228 NGS(ph)PTPAGSLGGGAVATAGGPGSR ddPTM_A459_Selumetinib_30min_R1 2 NGSPTPAGSLGGGAVATAGGPGSR 24 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 NGS(0.955)PT(0.045)PAGSLGGGAVATAGGPGSR;NGS(0.948)PT(0.052)PAGSLGGGAVATAGGPGSR 187.78 3.3194e-26 47375000.0 4964.6 6718.6 5795.9 6138.700000000001 5084.4 5119.299999999999 5123.700000000001 4983.7 3101.8999999999996 5691.6 True False 5080.265520570022 5931.983188607599 5008.848614599809 5066.691282670559 4624.5169177237285 5067.804489952498 4737.215183885467 4851.516086660931 5263.697746187682 6422.172300878805 0.7910509532537523 0.9236723822865779 0.7799305873363755 0.7889373011647846 0.720086086306173 0.7891106392861842 0.737634395644793 0.7554322524166868 0.8196132865303851 1.0 12.64884565640419 -8.616625624917441 7.866585512175679 0.9999999143059385 0.7866026016524621 0.6053724127886628 0.05163165677298207 3.201212274789479 268.8488201975187 0.05353259443463913 0.01383853350693517 2.417543933036084e-09 8.616625624917441 -0.2133973126534764 NGS(ph)YGESSLEAHIWQEEEEVVQANR ddPTM_A459_Selumetinib_30min_R1 1 NGSYGESSLEAHIWQEEEEVVQANR 25 0 Q8IY63-2;Q8IY63 Q8IY63-2 AMOTL1 Angiomotin-like protein 1 1 NGS(0.758)Y(0.014)GES(0.098)S(0.13)LEAHIWQEEEEVVQANR 94.807 5.4505e-06 1366900.0 0.0 170.03 134.61 0.0 233.55 180.35 0.0 199.37 0.0 0.0 True False 0.0 150.12280855519754 116.33070135980266 0.0 212.42544373660155 178.53584274469816 0.0 194.08205995497104 0.0 0.0 0.0 NGSEADIDEGLYS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 NGSEADIDEGLYSR 14 0 P22314;Q5JRR9;P22314-2;Q5JRS2;Q5JRS0;Q5JRS1;Q5JRS3 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 NGSEADIDEGLY(0.4)S(0.6)R 82.494 0.029732 8946200.0 11281.0 11367.0 12754.0 11887.0 10737.0 8280.7 13473.0 10971.0 7174.7 10921.0 True False 10654.047181421034 12238.812349334274 11933.42152550525 10267.970093781247 9388.122070002122 9421.291260289656 14099.521196243018 11002.92379365318 8609.840477867554 10605.682353834316 1.0045602749519678 1.1539863198815798 1.1251913009813 0.9681574227111399 0.8851973646568809 0.8883248569936226 1.3294308396051067 1.0374555287029927 0.8118139116956301 1.0 13.372549824257982 -5.7604190562771205 24.977141632514524 0.995897845281688 1.1005200110348332 0.11145651421709224 0.13570066271696093 66.6298909837208 1630984.7715174214 0.039858754040625666 0.06429658445757715 1.7361248113309693e-06 5.7604190562771205 0.1046221657531452 NGSLDS(ph)PGKQDTEEDEEEDEKDK ddPTM_A459_Selumetinib_30min_R2 3 NGSLDSPGKQDTEEDEEEDEKDK 23 2 A0A0A0MSS4;A0A0A0MSU9;Q9Y266 A0A0A0MSS4 NUDC Nuclear migration protein nudC 1 NGS(0.045)LDS(0.946)PGKQDT(0.009)EEDEEEDEKDK;NGS(0.014)LDS(0.493)PGKQDT(0.493)EEDEEEDEKDK;NGS(0.011)LDS(0.938)PGKQDT(0.051)EEDEEEDEKDK 123.43 1.1812e-05 49786200.0 251609.0 179199.0 166412.0 125900.0 106940.0 121832.0 255916.0 185636.0 103319.0 130039.0 True False 237625.57905063097 192942.98708439834 155705.23309568586 108752.20281038618 93505.24114426997 138613.25211921803 267816.601087934 186176.17002630595 123985.68697406117 126284.43618810223 1.8816695566244181 1.5278445460769794 1.2329724690995254 0.8611686926201929 0.7404336113517009 1.097627358550755 2.1207411552205677 1.4742606107770417 0.9817970505041727 1.0 16.94631732086365 NGSLDSPGKQDT(ph)EEDEEEDEKDKGK ddPTM_A459_Selumetinib_30min_R1 1 NGSLDSPGKQDTEEDEEEDEKDKGK 25 3 A0A0A0MSS4;A0A0A0MSU9;Q9Y266 A0A0A0MSS4 NUDC Nuclear migration protein nudC 1 NGS(0.005)LDS(0.222)PGKQDT(0.773)EEDEEEDEKDKGK 51.56800000000001 0.014245 87447000.0 4078.5 4508.5 6434.7 6592.9 2680.6 4566.9 2881.6 3618.7 3701.4 4975.3 True False 4173.521114620479 3980.6427240552152 5560.9030832770395 5441.573779060506 2438.1402032983688 4520.961132413429 2664.2385920105294 3522.7203208058077 6281.0054604400775 5613.928218525958 0.7434226003901979 0.7090654830460956 0.9905547179826889 0.9692987810395077 0.4343019911178252 0.8053115316819088 0.4745765332763865 0.6274965022140528 1.1188253956851042 1.0 12.454794901872216 -8.265009576579358 24.99721213107334 1.0594127371938993 0.7215064463989262 0.38092936678286404 0.17343725631128754 361.49072689581175 2530966.4822222847 0.1542714638347068 0.046002917436383975 5.43238352471819e-09 8.265009576579358 -0.33790629079497303 NGSMGS(ph)PVNQQPK ddPTM_A459_Selumetinib_30min_R2 2 NGSMGSPVNQQPK 13 0 A0A0A0MRW1;A0A0A0MRV9;Q5T586;A0A0A0MRW2;Q5T593;A0A0A0MRW0;A0A0A0MRW3;Q8IW50-3;Q8IW50-7;Q8IW50-2;Q8IW50-5;Q8IW50-6;Q8IW50-4;Q8IW50 A0A0A0MRW1 FAM219A Protein FAM219A 1 NGS(0.005)MGS(0.995)PVNQQPK;NGS(0.025)MGS(0.975)PVNQQPK 110.22 0.0056688 6194900.0 40265.0 25351.0 35113.0 40468.0 39686.0 32081.0 31294.0 28657.0 26172.0 30807.0 True False 38027.23249356598 27295.340183687273 32853.86780814379 34956.18858880619 34700.2898826585 36499.866547677375 32749.23300788462 28740.387125578272 31407.131306779327 29917.521863801307 1.2710689296621527 0.9123529785638181 1.0981480337078091 1.1684185858689524 1.1598651131811857 1.220016374144958 1.0946505916156626 0.9606540025747484 1.0497905357856652 1.0 14.868703058021284 -7.605001196204488 5.804071048585376 1.0054578592874215 1.1308020899888787 0.30265322363435443 0.09097782673904273 0.28368810873999073 15.460263300130153 0.044436421325119255 0.025260288945767026 2.483126265855979e-08 7.605001196204488 0.12534423070145717 NGSPSLGRDS(ph)PDTMLASPQEEGEGPSSTTESSER ddPTM_A459_Selumetinib_30min_R2 1 NGSPSLGRDSPDTMLASPQEEGEGPSSTTESSER 34 1 Q8IWE5;Q5VVD7 Q8IWE5 PLEKHM2 Pleckstrin homology domain-containing family M member 2 1 NGS(0.035)PS(0.089)LGRDS(0.615)PDT(0.231)MLAS(0.029)PQEEGEGPSSTTESSER 51.125 0.00388 5259600.0 8308.9 7684.9 8443.4 7024.0 8934.3 5149.4 7106.7 7745.9 6030.5 6199.0 True False 7847.124601162068 8274.307119151832 7900.160836478828 6067.319082924157 7811.893360344602 5858.683108400923 7437.175631658898 7768.439286597226 7236.768506248384 6020.018763063727 1.303505007211719 1.3744653372045048 1.3123149856194556 1.0078571715009668 1.2976526598679483 0.9732001408944617 1.2354073839919306 1.2904343976900974 1.2021172675823064 1.0 12.55555226821464 -5.579521142450225 13.09863248985815 1.1590529407982746 1.3400881164770242 0.35664643484631453 0.11374315630769266 1.152982617385496 264.97827842063674 0.03002123251895936 0.052006641741322544 2.6331697518198382e-06 5.579521142450225 0.1810351756787496 NGSTAVAESVAS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 3 NGSTAVAESVASPQK 15 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 NGSTAVAESVAS(1)PQK;NGSTAVAESVAS(1)PQK;NGSTAVAESVAS(1)PQK 224.36 6.2513e-10 40507000.0 17196.9 17710.6 19780.2 18925.9 13985.0 14648.6 15372.8 15444.999999999998 9222.1 15328.899999999998 True False 17597.554310657582 15637.034718565437 17094.157484861218 15620.846848142879 12720.059219252285 14501.248383864631 14213.21731928771 15035.34842756949 15649.23014446547 17296.513631130278 1.0174047028174216 0.9040570286038391 0.9883007552513439 0.9031211249432641 0.7354117419569869 0.8383914061019369 0.8217388557256274 0.8692704638759605 0.904762108607828 1.0 14.078193650130693 -5.998057692822093 13.16707878149422 0.8489393084081154 0.9604183202269275 0.3200871538174579 0.06876771865122898 0.20965501800424163 1297.059244654319 0.018964235561072393 0.02736791917954142 1.0044823433364583e-06 5.998057692822093 0.11147901181881215 NGSTAVAESVAS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 NGSTAVAESVASPQK 15 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 NGSTAVAESVAS(1)PQK;NGSTAVAESVAS(1)PQK 166.6 7.8459e-05 57585000.0 213662.0 187780.0 184855.0 186632.0 210877.0 155285.0 198849.0 178959.0 116603.0 176911.0 True False 201787.5213967541 202182.1221921338 172961.6305549062 161212.3996418428 184384.74599570085 176674.09921311954 208095.87251181854 179479.74106174274 139926.85816003298 171803.1197600207 1.1745276900595079 1.176824509790901 1.0067432465516561 0.9383554842719313 1.0732328158723456 1.0283521012883978 1.2112461799441858 1.0446826653232197 0.814460519433446 1.0 17.390396708942554 -5.257810322902315 23.94305817048352 1.0231102935447864 1.175676133760246 0.31274380523933676 0.09482770416358437 221.0040763369781 1458062.921173202 0.02537810359593609 0.061834593936566006 5.523186104708265e-06 5.257810322902315 0.1525658402154595 NGSVVSLQS(ph)PGSR ddPTM_A459_Selumetinib_30min_R1 2 NGSVVSLQSPGSR 13 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 NGSVVSLQS(0.98)PGS(0.02)R;NGSVVS(0.001)LQS(0.953)PGS(0.046)R 98.676 0.015293 4486300.0 2988.9 3823.8 4931.0 4687.3 4449.7 3517.7 3908.3 3648.8999999999996 2332.01 3342.7 True False 3058.535554613007 3376.1077183636066 4261.3972840441775 3868.7510465182695 4047.225420658344 3482.315131816052 3613.4937844096185 3552.119318702383 3957.250646728501 3771.7681056552783 0.8109023325233407 0.8950994928085769 1.1298142315946633 1.0257128588360398 1.073031349565222 0.9232580143500262 0.9580371017485545 0.9417650341166096 1.049176549532596 1.0 11.881025264199659 -5.030365685365095 7.615519814495894 1.0084770539014085 0.8307001551051638 0.5515916132408327 0.05964458151835025 0.14772210072329628 33.02190937833115 0.016074913359198254 0.04601473789108608 9.324688111977731e-06 5.030365685365095 -0.1777768987962447 NGTKS(ph)PEAATPVGK ddPTM_A459_Selumetinib_30min_R2 2 NGTKSPEAATPVGK 14 1 A0A2R8YH03;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 1 NGT(0.067)KS(0.933)PEAATPVGK;NGT(0.043)KS(0.957)PEAATPVGK 156.0 0.00031033 4559200.0 37543.0 34114.0 33502.0 34750.0 28417.0 25039.0 29491.0 29375.0 18988.4 24728.0 True False 35456.51035653665 36730.43410620122 31346.517794219613 30016.99005290637 24847.002408796714 28487.894968588695 30862.389935307892 29460.476386706952 22786.610580224988 24014.038388940116 1.4764909500963599 1.5295400761546942 1.3053413710147368 1.2499767663705814 1.034686544860369 1.1863017168203185 1.285181169258139 1.2268022524805842 0.9488870722685098 1.0 14.551590418427356 -1.5228787452816033 0.2634091131268353 1.0459724748615553 4.551388703256708 0.6838515872423702 0.10233813800948305 32.21118634846944 0.4464295981576399 0.13210624046877378 50.905784909531306 0.02999999999991257 1.5228787452816033 3.505416228395153 NGTSGS(ph)DSPGQAVEAEEIVK ddPTM_A459_Selumetinib_30min_R2 1 NGTSGSDSPGQAVEAEEIVK 20 0 Q05D32 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 NGTSGS(0.644)DS(0.356)PGQAVEAEEIVK 158.89 1.1942e-06 2966000.0 34804.0 28006.0 32906.0 31244.0 32363.0 20296.0 26062.0 29131.0 18346.0 25165.0 True False 32869.73301145093 30153.970146516724 30788.863785343863 26988.513301093728 28297.270611109147 23091.589771255887 27273.934640873278 29215.766387103333 22015.71263006931 24438.42106347777 1.3450023193426934 1.2338755465499613 1.259854869730376 1.104347667592444 1.1579009354822136 0.9448887762133427 1.116026873014029 1.1954850238162527 0.9008647724369926 1.0 14.576863456953397 -1.5228787483321855 0.2656186318007128 1.001559887616042 3.4560864040199983 0.6099606227035319 0.08455269412457679 35.81225680126935 0.4976658087962947 0.10026346949891773 40.07435717104008 0.029999999789185813 1.5228787483321855 2.4545265164039565 NGTSGSDS(ph)PGQAVEAEEIVK ddPTM_A459_Selumetinib_30min_R1 2 NGTSGSDSPGQAVEAEEIVK 20 0 Q05D32 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 NGT(0.009)S(0.029)GS(0.343)DS(0.62)PGQAVEAEEIVK;NGTSGS(0.004)DS(0.996)PGQAVEAEEIVK 224.08 5.201e-20 7220000.0 2463.88 2432.81 2985.06 3257.46 2427.83 2780.63 2516.83 2232.5299999999997 1531.34 2410.94 True False 2521.2836101240923 2147.975474217315 2579.7052477608836 2688.6057610973075 2208.2332051682006 2752.6593868100363 2326.983486788543 2173.3160521205364 2598.5721353515737 2720.4076335443015 0.9268036080457622 0.7895785351178458 0.9482789328891483 0.9883098870717545 0.8117287931188419 1.0118554855044704 0.8553804430245686 0.7988935280588876 0.9552142492579343 1.0 11.409607129825226 -5.286270536233767 24.85167533147307 0.9133982859931892 0.8581910108073387 0.08643284450482291 0.07874015541261926 1726.0312395467156 1727455.0065190264 0.020212340322925015 0.042102505678072166 5.172844981362868e-06 5.286270536233767 -0.055207275185850446 NGTSSTCQDS(ph)PEKTTLAAK ddPTM_A459_Selumetinib_30min_R2 1 NGTSSTCQDSPEKTTLAAK 19 1 Q9BX63;Q9BX63-2 Q9BX63 BRIP1 Fanconi anemia group J protein 1 NGT(0.012)S(0.036)S(0.112)T(0.128)CQDS(0.712)PEKTTLAAK 89.04299999999998 0.0016503 6932400.0 26852.0 25765.0 22406.0 22694.0 18745.0 15831.0 14754.0 14106.0 9724.6 20600.0 True False 25359.673337072745 27741.092652467447 20964.422353808255 19603.03805066641 16390.085517573796 18011.576550490343 15440.090234496363 14147.046124625997 11669.791728026372 20005.224474772192 1.267652525921558 1.3866923956514787 1.0479473689608267 0.9798959304549187 0.819290257814537 0.900343636393785 0.7718028984862059 0.7071675772729411 0.5833372048757909 1.0 14.288089196527077 -5.645530727972568 0.8893484593057318 0.7595105915388087 1.4035355577910626 0.7632347218953761 0.11402889609664753 0.37523659028901407 0.5070419837776451 0.04661763936138391 0.18394173573572362 2.2618784976733443e-06 5.645530727972568 0.6440249662522539 NGVAAEVS(ph)PAKEENPR ddPTM_A459_Selumetinib_30min_R1 2 NGVAAEVSPAKEENPR 16 1 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 NGVAAEVS(1)PAKEENPR;NGVAAEVS(1)PAKEENPR 100.41 0.0033152 58422000.0 9129.3 11632.4 10367.0 10773.9 8699.7 9135.8 9089.7 9472.0 6385.9 9192.3 True False 9341.994927474494 10270.473200243956 8959.218341854788 8892.440616150703 7912.813671056787 9043.902146642713 8404.05661084055 9220.771790607841 10836.40589231759 10372.22124558441 0.9006744752433337 0.9901903321447401 0.8637704624425405 0.8573323308096934 0.7628851606328177 0.871934943587211 0.8102465626076253 0.8889871872462464 1.044752675029063 1.0 13.340437264715922 -8.196540111783023 5.107274959766229 1.0222535314110903 0.8653417489793881 0.5464822161214169 0.0563348602544122 0.16229278358587346 8.272383933150333 0.04514011719102261 0.015825098484827414 6.3600406028468844e-09 8.196540111783023 -0.15691178243170223 NGVAAEVS(ph)PAKEENPR ddPTM_A459_Selumetinib_30min_R2 3 NGVAAEVSPAKEENPR 16 1 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 NGVAAEVS(1)PAKEENPR;NGVAAEVS(1)PAKEENPR;NGVAAEVS(1)PAKEENPR 61.56100000000001 0.037751 85847100.0 77086.0 70824.0 75892.0 78611.0 67778.0 47531.0 75389.0 67509.0 51341.0 66832.0 True False 72801.86871970759 76255.97306494668 71009.1913449619 67904.0461884611 59263.121696992086 54077.963806541404 78894.73788046952 67705.44001328341 61610.63458739712 64902.386509610435 1.1217132779690226 1.1749332677259112 1.094092146125431 1.0462488336758802 0.9131115954914337 0.8332199586918703 1.2155907066497034 1.0431887586022421 0.9492814964250061 1.0 15.985983907731926 -5.730156830578077 2.6101211456843654 0.997418515612286 1.145148260703172 0.3029272536731177 0.0942272893287734 0.369782000703986 5.126224584579493 0.02944774681688466 0.05464772959010721 1.8614148290654403e-06 5.730156830578077 0.147729745090886 NGYGFVEFEDS(ph)RDADDAVYELNGK ddPTM_A459_Selumetinib_30min_R1 2 NGYGFVEFEDSRDADDAVYELNGK 24 1 Q13247-3;Q13247;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-2 Q13247-3 SRSF6 Serine/arginine-rich splicing factor 6 1 NGY(0.002)GFVEFEDS(0.993)RDADDAVY(0.004)ELNGK;NGY(0.001)GFVEFEDS(0.75)RDADDAVY(0.25)ELNGK 66.31 0.0014258 38163000.0 4765.5 4497.6 4900.8 4597.0 4776.0 4115.6 4588.4 4937.9 2815.5 4147.2 True False 4876.526877951182 3971.0189011224866 4235.298278167454 3794.220246377337 4344.0116432712875 4074.2008006658148 4242.293293857967 4806.930851440292 4777.69786401606 4679.533517148884 1.0420967944946615 0.8485928964009052 0.905068478011011 0.8108116401929427 0.9283001451644648 0.8706425086464852 0.9065632884798064 1.0272243662374765 1.0209773787296184 1.0 12.192149005488131 -7.735612747524859 6.4659132343812535 1.0184102025294706 0.8956926400126627 0.4509576134447928 0.0575684100374706 0.1372146163374883 19.208254146516154 0.02743261220340758 0.015052084826441778 1.8381766814504887e-08 7.735612747524859 -0.12271756251680788 NHAGS(ph)PGCEESDAGK ddPTM_A459_Selumetinib_30min_R1 2 NHAGSPGCEESDAGK 15 0 P42575 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 1 NHAGS(1)PGCEESDAGK;NHAGS(1)PGCEESDAGK 165.17 5.8442e-05 26294500.0 9303.7 12728.5 11146.6 10114.5 8506.7 9421.4 8943.099999999999 9015.6 5074.1 9711.8 True False 9520.458108151171 11238.241302680888 9632.952943891058 8348.192447679701 7737.270486979864 9326.629269946765 8268.514766868882 8776.477001203984 8610.377102398825 10958.404130942929 0.8687814388290837 1.0255363069653356 0.879047060939354 0.7618073168251892 0.7060581444639696 0.8510937503766112 0.7545363967296402 0.8008900654085297 0.7857327581199485 1.0 13.419750093905202 -5.546250077228901 5.183004855956239 0.7963872374019528 0.9492178185307178 0.30680105296793125 0.08251457266527698 0.16774434176082423 12.483932645642557 0.02094976640311993 0.03873428609577018 2.84282366967585e-06 5.546250077228901 0.15283058112876502 NHAGS(ph)PGCEESDAGK ddPTM_A459_Selumetinib_30min_R2 2 NHAGSPGCEESDAGK 15 0 P42575 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 1 NHAGS(0.994)PGCEES(0.006)DAGK;NHAGS(1)PGCEESDAGK 178.0 1.9641e-05 7194300.0 25770.8 19365.1 25179.9 18004.3 25746.0 20774.5 17200.1 20309.7 17223.1 22197.2 True False 24338.562104686225 20850.340901389376 23559.852647802236 15552.083280850133 22511.55730783968 23635.99880286538 17999.93873135157 20368.797864548174 20668.201253621843 21556.30916074822 1.1290690777901904 0.9672500401578792 1.0929446442855004 0.721463176505598 1.0443140864221259 1.0964770743733838 0.8350195108598447 0.9449111957272176 0.958800558087025 1.0 14.395822562681259 -3.5407116167519623 1.1327125211745985 0.9532061024780071 3.376259508439617 0.17507932334281306 0.10852583114057397 41.039210390066316 4.577957492881904 0.03259640426115784 218.98068701345616 0.00028793097193894235 3.5407116167519623 2.42305340596161 NHAGS(ph)PGCEESDAGKEK ddPTM_A459_Selumetinib_30min_R1 1 NHAGSPGCEESDAGKEK 17 1 P42575 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 1 NHAGS(0.944)PGCEES(0.056)DAGKEK 72.801 0.014616 4046200.0 976.03 902.08 1714.7 1334.3 1084.5 1222.5 933.67 1028.9 591.41 977.03 True False 998.7695999762228 796.4640542343858 1481.8531581728964 1101.2895529130467 986.4071664840258 1210.20275994119 863.2425201979705 1001.6102296617831 1003.5795751226203 1102.441317578118 0.9059616907050936 0.7224548295995347 1.3441560421812597 0.9989552598884796 0.8947480022347128 1.0977480076670258 0.7830280908687023 0.9085383627149931 0.9103247121827032 1.0 10.106486148524498 -7.259580440626054 24.977972613073955 0.8928509947742732 0.993290250673407 0.07700499718958764 0.1577442274662078 470.2628423937688 6318819.444393763 0.0638794251642613 0.04691223227167515 5.500720259712e-08 7.259580440626054 0.10043925589913383 NHDDWSHDYDNRR ddPTM_A459_Selumetinib_30min_R1 2 NHDDWSHDYDNRR 13 1 G3V1T9;J3KPD3;Q9Y580 G3V1T9 RBM7 RNA-binding protein 7 0 ; 114.71 0.0013677 17698900.0 1976.3600000000001 1858.1100000000001 2772.4 2432.2 2103.6800000000003 1946.77 1323.47 1419.17 1082.99 1001.6400000000001 False True 2022.4053426728767 1640.561617388096 2395.9233077031195 2007.4619280485003 1913.4025154348699 1927.1872613257335 1223.6395923681905 1381.5290014861632 1837.7549315399583 1130.2102507998186 1.789406299616975 1.4515543601087637 2.119891680337876 1.7761844989707667 1.6929615654085668 1.7051581862418221 1.0826654522928407 1.2223646003108655 1.6260292545032482 1.0 10.142375464002333 -7.181223648293967 6.023396893959104 1.2525119071781528 1.7605890095482215 0.5852446299717935 0.21566022205234386 0.17468178282003335 10.430525337344225 0.0831272732691938 0.06397671054579299 6.58834528361777e-08 7.181223648293967 0.5080771023700688 NHDDWSHDYDNRR ddPTM_A459_Selumetinib_30min_R2 2 NHDDWSHDYDNRR 13 1 G3V1T9;J3KPD3;Q9Y580 G3V1T9 RBM7 RNA-binding protein 7 0 ; 115.33 0.0013282 6274700.0 6735.8 2369.9 3106.4 3499.2 3164.62 3447.2799999999997 4974.9 3579.0 2010.98 4263.7 False True 6361.45120154382 2551.6637095704496 2906.537605992591 3022.6029235433098 2767.0521435382457 3922.1115287078765 5206.242707577333 3589.414297464653 2413.2321914758954 4140.595902577 1.5363612753383198 0.6162551887718287 0.7019611849066549 0.729992251033751 0.6682738930925628 0.9472335917317736 1.257365565264918 0.8668835070890869 0.5828224362522221 1.0 12.015622695823051 -4.751181060568832 24.993138974963014 0.8213772797715543 1.5363627529728163 0.5460971991575436 0.19619842667166448 365.3614139316828 890098.3824034825 0.0527212585656241 0.7173121847501724 1.7734499623916905e-05 4.751181060568832 0.714985473201262 NHDEESLECLCR ddPTM_A459_Selumetinib_30min_R1 1 NHDEESLECLCR 12 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4;Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9JF13 A0A0A0MSA7;Q04637-9 EIF4G3;EIF4G1 Eukaryotic translation initiation factor 4 gamma 3;Eukaryotic translation initiation factor 4 gamma 1 0 111.31 0.009625299999999998 6160500.0 1141.0 977.45 1064.1 1536.2 1261.5 1285.2 991.77 1173.1 534.15 867.81 False True 1167.5830800004817 863.009699595823 919.601064682906 1267.9315080454353 1147.3975477359138 1272.2720548682341 916.9599904213925 1141.9855772341703 906.413537227554 979.2018666852266 1.1923824082902938 0.8813399248484535 0.9391332839222621 1.2948622252300337 1.1717681376773306 1.2992949647605376 0.9364361135518113 1.1662412175540429 0.9256656549235612 1.0 9.935462498065657 -8.267391086273184 24.246499747168617 0.9628328099926519 1.1055736497008848 0.1484423298296812 0.14082244568392085 730.1324688758236 2974397.2082875147 0.1285955833580077 0.03678791376203578 5.402675877700959e-09 8.267391086273184 0.14274083970823292 NHDEESLECLCR ddPTM_A459_Selumetinib_30min_R2 2 NHDEESLECLCR 12 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-4;Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9JF13 A0A0A0MSA7;Q04637-9 EIF4G3;EIF4G1 Eukaryotic translation initiation factor 4 gamma 3;Eukaryotic translation initiation factor 4 gamma 1 0 ; 204.32 4.7774e-05 11859000.0 41119.0 34835.0 44413.0 38454.0 45001.0 32850.0 33665.0 38039.0 28444.0 35711.0 False True 38833.77059239885 37506.7324878208 41555.515933218165 33216.49886315 39347.57206595563 37374.78931739045 35230.48920593197 38149.68719230454 34133.594791763375 34679.9306416791 1.1197764780338855 1.0815111735761198 1.1982583345560627 0.9578017674357654 1.1345920057483292 1.077706576277653 1.015875422876169 1.1000508503455717 0.9842463396031385 1.0 15.081813392786081 -6.864928037320093 0.2508221020232369 0.9859987432907047 1.150953251942875 0.2627112188108439 0.06184433502174503 4.73092605460323 0.7007437216952748 0.11748922948282081 0.26208059359648445 1.3648092670138054e-07 6.864928037320093 0.1649545086521702 NHEGDEDDSHVR ddPTM_A459_Selumetinib_30min_R2 2 NHEGDEDDSHVR 12 0 Q9UNE7;H3BTA3;H3BS86;Q9UNE7-2;H3BUD0 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 ; 180.24 5.8638e-05 6133500.0 19720.1 12556.7 9054.5 10743.599999999999 11247.8 8807.5 17101.9 28354.0 14810.5 21222.8 False True 18624.135787814987 13519.758513845842 8471.943327794199 9280.303146256263 9834.750807392182 10020.653178475386 17897.17223677197 28436.505445742612 17773.013839945568 20610.04262054344 0.9036437299382891 0.655979163302155 0.4110589911808155 0.45028063828485 0.4771824584966754 0.486202448144727 0.8683714326205533 1.3797402542679849 0.8623472627965353 1.0 14.33105986785132 -7.462515153388775 4.366084527209075 1.0985611577744603 0.555491754203396 0.628150948764926 0.17954080731685734 0.13598301154128456 5.217606513494779 0.08246189381801143 0.05222706227083436 3.4473457789574756e-08 7.462515153388775 -0.5430694035710643 NHGAYLGY(ph)T(ph)VT(ph)SVVSSR ddPTM_A459_Selumetinib_30min_R2 1 NHGAYLGYTVTSVVSSR 17 0 Q9UKX5;Q9UKX5-2 Q9UKX5 ITGA11 Integrin alpha-11 3 NHGAY(0.37)LGY(0.634)T(0.996)VT(0.966)S(0.034)VVSSR 89.506 0.014132 5804200.0 1378.4 3235.9 2555.4 3426.5 2406.7 976.44 3168.1 1470.5 0.0 2315.1 True False 1301.7940461723927 3484.0831249415623 2390.9883461091513 2959.8047889578042 2104.3488298290144 1110.935746760205 3315.422927471055 1474.7789115456205 0.0 2248.2570476478186 0.5790236697064338 1.5496818429132448 1.0634853112595206 1.316488607054262 0.9359912079584652 0.4941319979058858 1.4746636426380744 0.6559654346857581 0.0 1.0 11.134591275810989 -7.988231930587502 23.739052836530753 0.44266088004296167 1.0618147129061404 0.26161492888206483 0.39383729110417903 129.868304690772 261975.59258429837 0.20561952427059038 0.09862486985239172 1.0274674429599842e-08 7.988231930587502 0.6191538328631787 NHLLHVFDEYKR ddPTM_A459_Selumetinib_30min_R1 1 NHLLHVFDEYKR 12 1 P09525;Q6P452;P09525-2 P09525 ANXA4 Annexin A4;Annexin 0 70.41199999999998 0.020897 5543000.0 3721.1 5965.1 6856.9 4221.0 4019.4 2813.7 2287.7 3001.6 1922.1 3071.9 False True 3807.7943899998218 5266.703318900248 5925.770642255631 3483.881587983194 3655.845979682706 2785.396732635193 2115.1369471621642 2921.987817429107 3261.663315370366 3466.2082878399056 1.0985474829537114 1.519442249727695 1.7095829650642524 1.0050987415283985 1.0547104144052981 0.8035860806192391 0.6102163434847389 0.8429925655881605 0.940988839826181 1.0 11.759142634718446 -5.916760918177354 5.319371891040939 0.8650445488134094 1.4478713858079715 0.6627087595456561 0.18092203998813455 0.12401666816057047 5.929920240047565 0.05459362711338663 0.08205538193957536 1.2112647588519993e-06 5.916760918177354 0.5828268369945621 NHLLQFALES(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 NHLLQFALESPAK 13 0 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 NHLLQFALES(1)PAK 142.91 0.00049643 16000000.0 5529.9 9768.4 6502.9 6339.5 4383.5 5507.3 5584.7 4873.2 3848.1 6952.4 True False 5658.735910687703 8624.711186794044 5619.84189787282 5232.425332153388 3987.013198969781 5451.9015622283105 5163.441582732233 4743.946905615514 6529.944645896002 7844.808262110796 0.7213351456935561 1.0994164418842534 0.7163772153636669 0.6669921248968173 0.5082359014721156 0.6949693835807494 0.6581985703424841 0.6047243918666616 0.8323905986886408 1.0 12.937522470837951 -2.464769114931096 11.62836427156563 0.7349122272197148 0.9847794712653716 0.0 0.17134449271414368 0.0 0.0 0.04033633583760778 0.0 0.003429500614952028 2.464769114931096 0.24986724404565674 NHLLQFALES(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 NHLLQFALESPAK 13 0 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 NHLLQFALES(1)PAK 119.92 0.0020737 2444100.0 44120.0 31496.0 36251.0 31193.0 31555.0 25549.0 32382.0 30513.0 18610.0 31239.0 True False 41667.98702635368 33911.64192439799 33918.65012710452 26944.459589073645 27590.778794720776 29068.14283926965 33887.82716371571 30601.787778300917 22332.520006845625 30337.04890133048 1.3735016600288457 1.1178292929774967 1.1180603043302924 0.888170094484436 0.9094747114150163 0.9581730554548047 1.117044287133331 1.0087265863542458 0.7361467517648428 1.0 14.88879313084009 -4.575326714614982 1.020160021957925 0.9541997550330684 1.7236460401688916 0.6265583178202992 0.10004325161614833 1.8413915047631422 1.175539523471677 0.03348060957343325 1.7110119993640487 2.6587241804405686e-05 4.575326714614982 0.7694462851358231 NHLLQFALES(ph)PAKSPASSSSK ddPTM_A459_Selumetinib_30min_R1 1 NHLLQFALESPAKSPASSSSK 21 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 NHLLQFALES(0.957)PAKS(0.003)PAS(0.005)S(0.005)S(0.015)S(0.015)K 65.854 0.005363399999999999 10560000.0 2050.3 2317.8 2713.1 2545.9 1279.1 2300.0 1591.6 1424.3 1528.1 1327.9 True False 2098.0680008106824 2046.4308984840138 2344.6759219915352 2101.3063574618345 1163.4056308434467 2276.8640882329123 1471.5443305954893 1386.5229372215742 2593.074091991809 1498.3488998413402 1.4002533061777842 1.3657906370810629 1.5648397527704077 1.4024145896088296 0.7764584276510227 1.5195820469277943 0.9821105957039183 0.925367207443068 1.7306210137481257 1.0 10.549157888072587 -6.031424998245241 24.71302452491371 1.1549250069773904 1.4438081440898511 0.2017821748968801 0.2714467476558461 895.480664937172 704216.3592480383 0.07680817979114438 0.09927668163571517 9.301971439976369e-07 6.031424998245241 0.2888831371124607 NHLS(ph)PQQGGATPQVPS(ph)PCCR ddPTM_A459_Selumetinib_30min_R2 1 NHLSPQQGGATPQVPSPCCR 20 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 2 NHLS(0.998)PQQGGAT(0.002)PQVPS(1)PCCR 149.12 0.00031381 6184100.0 17231.0 14901.0 15684.0 17001.0 17338.0 12718.0 12378.0 11797.0 9144.8 15817.0 True False 16273.370001158226 16043.858785733268 14674.908515448036 14685.43447163917 15159.845436313382 14469.78905749077 12953.601526541685 11831.327316901517 10974.01552706082 15360.322112498614 1.0594419753682554 1.0445001522903263 0.9553776547112341 0.9560629239467386 0.9869484067640675 0.9420238033756323 0.8433157476561906 0.7702525526645322 0.7144391534687492 1.0 13.906920849855377 -7.174150286311393 2.0548449331628245 0.8058350309741096 0.9988534596083104 0.519534680991113 0.07558262296567927 0.24607545100992412 2.035921278175032 0.03575049039764934 0.02449844127174712 6.696528379477222e-08 7.174150286311393 0.19301842863420082 NHLS(ph)PQQGGATPQVPSPCCR ddPTM_A459_Selumetinib_30min_R1 2 NHLSPQQGGATPQVPSPCCR 20 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 NHLS(1)PQQGGATPQVPSPCCR;NHLS(0.825)PQQGGAT(0.175)PQVPSPCCR 176.44 4.451100000000001e-13 25713000.0 5431.700000000001 6339.4 8905.3 8504.0 7105.7 6517.9 6144.5 6177.3 3265.3 5996.0 True False 5558.24804175164 5597.180100892897 7696.009173311416 7018.936039850529 6462.990689613227 6452.335843779695 5681.015418034673 6013.457937301717 5540.975611923863 6765.645005985895 0.8215400064345657 0.8272943815321081 1.1375130037863916 1.0374378250175016 0.9552660069949139 0.9536911614592548 0.8396857081635826 0.8888225634039797 0.8189870451407799 1.0 12.724011765438728 -7.167403877132469 6.515620585548244 0.8778463820034735 0.9622588568938718 0.10197112704450284 0.09717544268104653 0.5345773932588449 31.16243356796269 0.03992369529161952 0.030828046395497896 6.801365637069404e-08 7.167403877132469 0.08441247489039827 NHLS(ph)PQQGGATPQVPSPCCR ddPTM_A459_Selumetinib_30min_R2 5 NHLSPQQGGATPQVPSPCCR 20 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 NHLS(1)PQQGGATPQVPSPCCR;NHLS(0.517)PQQGGAT(0.025)PQVPS(0.458)PCCR;NHLS(1)PQQGGATPQVPSPCCR;NHLS(0.999)PQQGGAT(0.001)PQVPSPCCR;NHLS(0.635)PQQGGAT(0.358)PQVPS(0.008)PCCR 136.53 0.00010164 98551000.0 131374.0 110588.0 125192.0 135973.0 145004.0 92676.0 97658.0 112062.0 96110.0 121947.0 True False 124072.75901179042 119069.74400353452 117137.28301874356 117453.24283349157 126787.30116779244 105441.27777103437 102199.29050565595 112388.08186713718 115334.68553777161 118426.07325364268 1.0476811026745247 1.0054352114547718 0.9891173438459046 0.9917853358350612 1.0706029313007943 0.8903552644627697 0.8629796437374689 0.9490146787728624 0.97389605488945 1.0 16.85362722105058 -6.768040695399727 24.99998457216647 0.9275457017148184 1.016677982988599 0.48881864949306975 0.04334229550890732 136.72537006869823 517792.3594920398 0.015585178773081229 0.014062764573773335 1.7059225286898096e-07 6.768040695399727 0.08913228127378059 NHLSPQQGGAT(ph)PQVPSPCCR ddPTM_A459_Selumetinib_30min_R2 1 NHLSPQQGGATPQVPSPCCR 20 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 NHLSPQQGGAT(0.973)PQVPS(0.026)PCCR 145.82 5.9988e-05 7582100.0 5775.1 5410.0 6931.9 7471.6 6602.3 4192.2 5702.0 4386.5 2488.3 5682.6 True False 5454.143061557007 5824.9296041082425 6485.909100882065 6453.9551907710875 5772.860048689114 4769.6374969973895 5967.154298298649 4399.263988775832 2986.029528911014 5518.528572832056 0.9883328480725784 1.0555222333693461 1.1752968232895384 1.169506527979972 1.0460868277658546 0.864295152964961 1.0812944464354495 0.79718061267882 0.5410916133716079 1.0 12.430067931437067 -7.821001029404328 4.937825395514787 0.7411113774833861 1.0561741998459075 0.4687143547028133 0.13313898245831207 0.16476495171027594 8.00076146514421 0.0750258797459435 0.03552536310575893 1.5100765748389014e-08 7.821001029404328 0.3150628223625215 NHLSPQQGGATPQVPS(ph)PCCR ddPTM_A459_Selumetinib_30min_R2 1 NHLSPQQGGATPQVPSPCCR 20 0 Q9H4L4;A0A087X0R7 Q9H4L4 SENP3;SENP3-EIF4A1 Sentrin-specific protease 3 1 NHLS(0.033)PQQGGAT(0.451)PQVPS(0.515)PCCR 132.06 0.00014861 8712000.0 7466.2 5654.0 6916.5 7597.0 7633.7 4821.4 5112.3 5218.2 3884.7 5784.0 True False 7051.258493566678 6087.643619524585 6471.499920115811 6562.275494444026 6674.6863598561295 5485.504085688471 5350.032079830267 5233.384098080489 4661.748547586951 5617.000891363216 1.2553422422290865 1.0837889715996014 1.152127273126569 1.1682881347827945 1.1883007478455676 0.976589498877072 0.9524712890924685 0.9317043381864898 0.8299355185709377 1.0 12.45558431652025 -6.854473528702766 3.990920897829182 0.9275593104776175 1.164115830395548 0.8105692092100958 0.05616589483395191 0.09568358544028792 2.8591443368595697 0.02027230739571123 0.017969453946271502 1.3980621279879824e-07 6.854473528702766 0.23655651991793036 NHPMT(ph)PEAVK ddPTM_A459_Selumetinib_30min_R2 2 NHPMTPEAVK 10 0 E7ER27;A0A2R8YD50;P51659-3;P51659;P51659-2;A0A2R8Y7L2;E7ET17 E7ER27 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 1 NHPMT(1)PEAVK;NHPMT(1)PEAVK 129.54 0.0039743 6035900.0 140003.0 102981.0 127254.0 130732.0 112790.0 95742.0 105138.0 108000.0 84036.0 109461.0 True False 132222.19373641428 110879.31156389472 119066.61618367917 112926.07607472116 98620.31184460639 108929.59144065728 110027.12532699468 108314.26211963748 100845.54816202453 106300.5765161669 1.2438520850007342 1.0430734733318352 1.1200937952163479 1.062327973899056 0.9277495482783911 1.0247318971415977 1.0350567130768196 1.0189433178018967 0.948682984298653 1.0 16.69778989571561 -1.5228787452858799 0.571005237516585 0.9976070767167646 12.542094607336017 0.6828390925069108 0.047673127220007154 90.45164867837343 0.773824997075586 0.022990739907713883 1290.6513264384598 0.029999999999617152 1.5228787452858799 11.544487530619252 NHSDSSTSESEVS(ph)SVSPLK ddPTM_A459_Selumetinib_30min_R1 2 NHSDSSTSESEVSSVSPLK 19 0 Q9NY27-2;Q9NY27-3;Q9NY27;H7C559;C9IZ04 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 NHSDSS(0.001)T(0.001)S(0.174)ESEVS(0.552)S(0.27)VS(0.002)PLK;NHSDS(0.061)S(0.002)TS(0.21)ESEVS(0.722)S(0.004)VSPLK 164.22 3.8839e-07 155121900.0 7184.2 9038.2 5796.0 5247.7 7623.9 7711.5 8720.7 7499.6 2770.2 6499.0 True False 7351.577881980252 7980.003342254813 5008.935035149069 4331.287706529117 6934.319591108867 7633.929311481787 8062.890577924154 7300.68624586598 4700.827072597154 7333.209955620806 1.0025047593714902 1.0882005820845548 0.6830480874626791 0.590640078866042 0.9456049442296146 1.0410078748161962 1.0995035771127837 0.9955648740522017 0.6410326584191189 1.0 12.84022913013577 -6.494999221766442 24.94706728789894 0.9673894019988732 0.8375421429307022 0.08868629125843397 0.17496034624174442 1795.9787357601547 1607073.720574462 0.058935346450734116 0.06666839117776009 3.198900841953396e-07 6.494999221766442 -0.12984725906817107 NHSDSSTSESEVSS(ph)VSPLK ddPTM_A459_Selumetinib_30min_R1 2 NHSDSSTSESEVSSVSPLK 19 0 Q9NY27-2;Q9NY27-3;Q9NY27;H7C559;C9IZ04 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 NHSDSST(0.001)S(0.006)ESEVS(0.06)S(0.857)VS(0.076)PLK;NHSDSSTSESEVS(0.008)S(0.58)VS(0.412)PLK 334.98 4.614299999999998e-155 50480000.0 9315.1 11701.0 8110.1 7665.5 7540.6 8709.5 10669.4 10116.4 4073.3 10007.8 True False 9532.123705970629 10331.041480352678 7008.792965590483 6326.864324256136 6858.55406140106 8621.890337593286 9864.598568016785 9848.080209301643 6912.092597938774 11292.398614227095 0.8441185997420666 0.9148668793303825 0.6206646794030303 0.560276389489566 0.6073602514137331 0.763512751554016 0.8735609594571476 0.8720981738011107 0.6121013642956554 1.0 13.463064340532458 -7.001637173990923 24.910093038370935 0.8273181089052988 0.7054270632496026 0.1691064836299997 0.1346297873274838 126.65494913268239 1927125.6565940194 0.05128704254255669 0.044591257521136775 9.962373640950169e-08 7.001637173990923 -0.1218910456556962 NHSDSSTSESEVSS(ph)VSPLK ddPTM_A459_Selumetinib_30min_R2 3 NHSDSSTSESEVSSVSPLK 19 0 Q9NY27-2;Q9NY27-3;Q9NY27;H7C559;C9IZ04 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 NHSDSSTSESEVS(0.001)S(0.512)VS(0.488)PLK;NHSDSSTS(0.008)ESEVS(0.103)S(0.872)VS(0.017)PLK;NHSDSSTSESEVS(0.001)S(0.62)VS(0.379)PLK 222.93 1.6054e-19 276426000.0 402483.0 279205.0 453624.0 522925.0 550918.0 422066.0 395743.0 426120.0 373097.0 480983.0 True False 380114.60612710635 300619.1257144249 424438.3257084676 451701.71290405985 481706.75557059003 480201.7603663231 414145.8336498777 427359.93865203654 447726.82520118554 467095.7710460855 0.8137830177220824 0.6435920518851467 0.908675162607265 0.9670430367897576 1.0312804898485433 1.0280584628092138 0.8866400839433343 0.9149300103808294 0.9585332451169014 1.0 18.833358857878366 -5.420254162478173 4.759397788876034 0.9658021027696028 0.7308970763749522 0.730272775924139 0.05757155044193461 0.11125748116011727 3.9891757047677996 0.01583219019454228 0.034012388242404476 3.799669628950934e-06 5.420254162478173 -0.2349050263946506 NHSDSSTSESEVSSVS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 4 NHSDSSTSESEVSSVSPLK 19 0 Q9NY27-2;Q9NY27-3;Q9NY27;H7C559;C9IZ04 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 NHSDSSTSESEVS(0.001)S(0.499)VS(0.499)PLK;NHSDSSTSESEVSS(0.177)VS(0.823)PLK;NHSDSSTSESEVS(0.001)S(0.209)VS(0.79)PLK;NHSDSSTSESEVSS(0.079)VS(0.921)PLK 356.36 6.0116999999999945e-195 172822000.0 20867.059999999998 26842.300000000003 16216.18 15121.990000000002 17776.08 19007.489999999998 23624.9 20422.14 7132.700000000001 19348.899999999998 True False 21353.221897769374 23699.591037353293 14014.111825100685 12481.218321408662 16168.236702621818 18816.29190802009 21842.854772483886 19880.478506740288 12103.670948203642 21832.519789246246 0.978046606800148 1.0855179001842328 0.6418916350646539 0.5716801561108109 0.7405575196402933 0.8618470103156936 1.0004733756496 0.9105901974966971 0.5543872656497206 1.0 14.414191027407202 -6.901713603284974 9.945017814120895 0.8691738617396658 0.7974441137649728 0.027714558318825744 0.18142998444258726 1.5439465484729868 143.27710503990863 0.06966215469156041 0.06144525055552269 1.253967834948097e-07 6.901713603284974 -0.071729747974693 NHSDSSTSESEVSSVS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 NHSDSSTSESEVSSVSPLK 19 0 Q9NY27-2;Q9NY27-3;Q9NY27;H7C559;C9IZ04 Q9NY27-2 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 NHSDSST(0.001)S(0.215)ESEVS(0.004)S(0.311)VS(0.469)PLK;NHSDSST(0.001)S(0.005)ESEVS(0.043)S(0.043)VS(0.908)PLK 227.64 1.6856999999999998e-23 84474000.0 140354.0 100596.0 171123.0 196210.0 199816.0 151273.0 152088.0 158453.0 137072.0 185618.0 True False 132553.68656157865 108311.38973287876 160113.13248463467 169485.8595188706 174713.3277022954 172109.48263042927 159160.3933566547 158914.0719966937 164490.23011167877 180258.72604651767 0.7353523985705511 0.6008662776465415 0.8882406749247511 0.9402366433852027 0.9692364499303562 0.9547914068027674 0.8829552768257204 0.8815887889703838 0.9125229813797215 1.0 17.459709574232036 -5.355789922725913 5.114641926177354 0.9282529267845075 0.6694842175163431 0.8340457242210746 0.04670509666785699 0.07583481137615293 3.1277107442525853 0.01233286334330843 0.02668007529189837 4.40768020607541e-06 5.355789922725913 -0.2587687092681644 NHSGNDERDEEDEER ddPTM_A459_Selumetinib_30min_R2 1 NHSGNDERDEEDEER 15 1 A0A0D9SGE8;Q8IWS0-3;Q8IWS0-5;Q8IWS0 A0A0D9SGE8;Q8IWS0-5 PHF6 PHD finger protein 6 0 86.699 0.015466 2901600.0 2490.8 0.0 469.97 1027.3 823.23 577.57 756.85 703.84 555.65 590.68 False True 2352.3713074624175 0.0 439.73264186464655 887.379967808654 719.8084876304231 657.1250248415586 792.0450246698239 705.8880578730153 666.7955261581817 573.6255336290504 4.100883188689502 0.0 0.7665848468820268 1.5469673433025748 1.254840388775137 1.145564460292148 1.3807701684040097 1.2305729373781604 1.1624230217572253 1.0 9.163965433514912 -4.748315114346254 24.99861086954642 1.087139724311979 4.10089042729683 0.8351015809703387 0.4059141275118569 262.83785598494677 500614.3841272708 0.10578156397342917 1.9607226518414016 1.78519180963767e-05 4.748315114346254 3.0137507029848507 NHSPS(ph)PPVTPTGAAPSLASPK ddPTM_A459_Selumetinib_30min_R2 1 NHSPSPPVTPTGAAPSLASPK 21 0 Q5SYE7-2;Q5SYE7 Q5SYE7-2 NHSL1 NHS-like protein 1 1 NHS(0.153)PS(0.72)PPVT(0.124)PT(0.002)GAAPSLASPK 76.294 0.011894 0.0 11201.0 9608.1 11772.0 8792.9 10112.0 7002.8 7719.6 7197.7 6745.5 9933.2 True False 10578.493261155667 10345.010375089176 11014.602336384492 7595.291851401456 8841.640157573014 7967.372134910864 8078.5766960972105 7218.644115356617 8094.788485017574 9646.402706446943 1.0966257145874476 1.07242157412476 1.1418352179121805 0.7873703889974782 0.9165738178921263 0.8259423100370941 0.8374703961610567 0.7483249803092098 0.8391510007774832 1.0 13.23577532392079 -5.75973952495098 24.99999997005516 0.8413670790757384 1.1005069523736564 0.7475201907824607 0.06720333453702781 20.23276214995883 297555.4818906193 0.0177970581477787 0.028880413270425898 1.738843415163026e-06 5.75973952495098 0.259139873297918 NHSPSPPVTPTGAAPS(ph)LASPK ddPTM_A459_Selumetinib_30min_R2 1 NHSPSPPVTPTGAAPSLASPK 21 0 Q5SYE7-2;Q5SYE7 Q5SYE7-2 NHSL1 NHS-like protein 1 1 NHSPSPPVTPTGAAPS(0.5)LAS(0.5)PK 78.429 0.009254 0.0 11609.0 10215.0 11262.0 9350.9 10902.0 6875.9 8277.4 6801.0 4579.8 9148.5 True False 10963.818254509073 10998.457653598096 10537.415181138473 8077.291288797761 9532.393294883412 7822.992811794366 8662.315501356941 6820.789784033841 5495.887970303681 8884.359034342398 1.2340584404714563 1.23795735979193 1.1860636361504755 0.9091585850566231 1.072941025687508 0.8805354197815136 0.9750073660770405 0.7677300925894764 0.6186026419080299 1.0 13.117051980856179 -5.9652296320497395 0.5907403750102069 0.8020850882741586 1.3202549002662591 0.642152331186048 0.11545763055157748 0.7624236356719789 0.48401407277298975 0.07749904046768029 0.2292779357534442 1.0833539420465604e-06 5.9652296320497395 0.5181698119921005 NHSVNEEEQEEQGEGS(ph)EDEWEQVGPR ddPTM_A459_Selumetinib_30min_R1 4 NHSVNEEEQEEQGEGSEDEWEQVGPR 26 0 Q14694;Q14694-3;Q14694-2;H3BNA1 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 NHSVNEEEQEEQGEGS(1)EDEWEQVGPR;NHSVNEEEQEEQGEGS(1)EDEWEQVGPR;NHS(0.001)VNEEEQEEQGEGS(0.999)EDEWEQVGPR;NHSVNEEEQEEQGEGS(1)EDEWEQVGPR 184.06 2.5975000000000003e-22 125782300.0 4170.88 5244.1 6047.57 6283.799999999999 4269.78 5050.8 4693.7300000000005 4085.3999999999996 2703.1499999999996 4613.68 True False 4268.05338888029 4630.118334084052 5226.343210924162 5186.4522915348925 3883.579152890884 4999.993537759477 4339.678167156299 3977.0419207505597 4587.0481197353965 5205.890769048864 0.8198507379862063 0.889399824063153 1.0039287112969977 0.9962660612032928 0.7459970493388643 0.9604491833533023 0.8336091477288478 0.7639503203554884 0.8811264629306595 1.0 12.345929325830781 -6.238165660165075 24.984906554367875 0.85567023207766 0.9301188827887918 0.10578486277580945 0.08776424595578786 1640.913263333448 1761560.4505325262 0.02591218960259195 0.033429969404649824 5.778755766701641e-07 6.238165660165075 0.07444865071113183 NHSVNEEEQEEQGEGS(ph)EDEWEQVGPR ddPTM_A459_Selumetinib_30min_R2 3 NHSVNEEEQEEQGEGSEDEWEQVGPR 26 0 Q14694;Q14694-3;Q14694-2;H3BNA1 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 NHSVNEEEQEEQGEGS(1)EDEWEQVGPR;NHSVNEEEQEEQGEGS(1)EDEWEQVGPR;NHSVNEEEQEEQGEGS(1)EDEWEQVGPR 173.96 5.7388e-18 213530000.0 101125.1 83316.8 100980.1 91226.7 106706.0 67306.2 63771.0 95152.1 55026.6 88851.6 True False 95504.97177784954 89706.93065426347 94483.15030482007 78801.4660851648 93300.63831625653 76577.01810514905 66736.47785983914 95428.97685772188 66033.4575716653 86286.22344381892 1.1068391681324767 1.0396437238057101 1.0949969361718348 0.9132566351854828 1.081292407901068 0.887476761049908 0.7734314377925157 1.1059584375002323 0.7652838997486057 1.0 16.39684261501555 -6.032278984481591 0.903916672008474 0.9117002885347499 1.0909889098259602 0.2747428487604221 0.10808637665199682 0.8726926647523643 1.4530976290642452 0.04781036179842723 0.10387868886266953 9.283698238673957e-07 6.032278984481591 0.17928862129121026 NIDDGTSDRPYSHALVAGIDR ddPTM_A459_Selumetinib_30min_R1 3 NIDDGTSDRPYSHALVAGIDR 21 1 K7ELC7;P61353 K7ELC7 RPL27 60S ribosomal protein L27 0 ;; 100.28 0.00021999 52344000.0 19611.3 25875.9 18567.399999999998 19178.1 21469.7 19224.0 23009.600000000002 21106.7 9158.6 19067.8 False True 20068.205133052983 22846.337598620456 16046.049063427674 15829.004852523212 19527.769425783405 19030.624013995446 21273.967346864767 20546.88175177602 15541.475282321959 21515.337866100384 0.9327394837090842 1.0618628320318966 0.7457958207902403 0.7357079377992678 0.9076208585388474 0.8845143000975197 0.9887814674007085 0.9549876408936034 0.7223440031034392 1.0 14.39307787537461 -6.476703476696566 24.997985583361476 0.9104328939605385 0.8674566325115916 0.03042618951262932 0.11243210753168432 2038.8125175833884 1103755.6854539972 0.03700810892573809 0.041961849115091106 3.336541440963908e-07 6.476703476696566 -0.04297626144894695 NIDDGTSDRPYSHALVAGIDR ddPTM_A459_Selumetinib_30min_R2 4 NIDDGTSDRPYSHALVAGIDR 21 1 K7ELC7;P61353 K7ELC7 RPL27 60S ribosomal protein L27 0 ;;; 114.75 6.1844e-05 92727100.0 262137.0 208222.0 253225.0 272856.0 313557.0 223191.0 237837.0 235229.0 223064.0 270074.0 False True 247568.47495755376 224191.95786074433 236932.77919053377 235692.5420971465 274165.16642485367 253933.53432382626 248896.89176507495 235913.47744574258 267683.0329289095 262276.26188347704 0.94392253869907 0.8547931720955645 0.9033710389535643 0.8986422957402792 1.0453297010411815 0.9681910688381046 0.9489874911960343 0.8994846721986346 1.020614793754513 1.0 18.00072771241428 -6.124586635566193 13.17038628768925 0.9732194746832108 0.8969240426613035 0.4530182819150067 0.04270619139504213 0.722593424918195 73.54908971527718 0.012675693850723355 0.016366910440080068 7.506083035135562e-07 6.124586635566193 -0.07629543202190725 NIDEHANEDVER ddPTM_A459_Selumetinib_30min_R1 1 NIDEHANEDVER 12 0 P61026 P61026 RAB10 Ras-related protein Rab-10 0 129.76 0.00318 15093000.0 5643.2 5606.7 6822.2 4968.6 5993.1 5898.0 5216.7 6195.7 3099.1 4677.5 False True 5774.675580244275 4950.2649575158875 5895.782711662179 4100.927282173252 5451.025163167741 5838.671474955529 4823.200119010734 6031.369909530089 5258.946350691591 5277.902687708307 1.0941231625381993 0.9379227413655326 1.1170692338441275 0.7769994114752987 1.0328013769300102 1.1062484135134198 0.9138478680638564 1.14275883175651 0.9964083579902177 1.0 12.365749035619015 -6.479801464007604 24.99864028311117 1.0374140553533808 0.9776960669663352 0.051367001496647524 0.10441589216717131 1376.946413134708 799071.434752173 0.031132367204647345 0.03529812819393142 3.312825313612952e-07 6.479801464007604 -0.05971798838704567 NIEDVIAQGIGK ddPTM_A459_Selumetinib_30min_R2 1 NIEDVIAQGIGK 12 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 140.24 0.041245 0.0 18915.0 19524.0 25175.0 25581.0 23805.0 14551.0 16569.0 22145.0 16173.0 17376.0 False True 17863.78002274435 21021.428020445343 23555.267908467507 22096.82367031362 20814.403080599845 16555.268169173458 17339.491330850633 22209.438283697888 19408.05191137636 16874.30973173017 1.0586376750661153 1.2457652108232316 1.3959248279160466 1.3094949672971288 1.2334965643934335 0.981093059945629 1.0275674446253493 1.316168698855612 1.1501538267299778 1.0 14.042540867373495 -6.548862582839416 23.687983264692935 1.110181787049538 1.26338436739444 0.2895067308205903 0.11898833170799357 177.16122192321444 161505.7353127024 0.04177161791044933 0.04177340078564219 2.825773949906954e-07 6.548862582839416 0.15320258034490197 NIEDYIHR ddPTM_A459_Selumetinib_30min_R1 1 NIEDYIHR 8 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 96.034 0.030075 3239600.0 1462.7 1726.9 1716.2 1687.7 1711.4 1594.4 1481.6 1573.8 884.18 1716.6 False True 1496.7780640812493 1524.7137451859703 1483.1494664118059 1392.9748770526503 1556.6041721722104 1578.361783599372 1369.8417191569965 1532.0577115771343 1500.3888820478503 1936.9423310999643 0.7727530345373002 0.7871756018260518 0.7657168944051859 0.7191617709452393 0.8036399159536335 0.8148728840589905 0.707218638966438 0.7909671274038906 0.774617219086641 1.0 10.919565285647845 -9.434206520965928 1.5256494985345672 1.000146843000268 0.7696036706201262 0.8196626109886291 0.03227921792799973 7.4157740442639195 11.837453158902095 0.033553967763207015 0.008930706265603749 3.6795395811557975e-10 9.434206520965928 -0.23054317238014177 NIEDYIHR ddPTM_A459_Selumetinib_30min_R2 2 NIEDYIHR 8 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 ; 134.77 0.0038274 3913600.0 52171.0 50062.0 49673.0 57537.0 57657.0 44989.0 42152.0 48667.0 39510.0 47699.0 False True 49271.54467706024 53901.594425298834 46477.09325987315 49700.36134313882 50413.612199880066 51185.826380519866 44112.151522603446 48808.612912744415 47413.10400163727 46321.805933114505 1.063679269072647 1.163633268165948 1.0033523590807938 1.0729366081905942 1.0883343424190726 1.1050049830619444 0.9522977490622527 1.0536854496394352 1.023559057047528 1.0 15.499403879853276 -7.241104408930244 24.959889205564078 1.01185934345425 1.0826854138450464 0.41163824895505785 0.044053572883769467 851.844822624264 1045587.6379056578 0.016684675907946703 0.01290852268852997 5.739784552022155e-08 7.241104408930244 0.07082607039079636 NIGNGIIS(ph)SPLTGK ddPTM_A459_Selumetinib_30min_R2 1 NIGNGIISSPLTGK 14 0 A0A075B784;Q9P275;E9PEW0;K7EMM6 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 NIGNGIIS(0.506)S(0.494)PLTGK 176.4 6.9237e-05 13116000.0 61926.0 55168.0 62737.0 68074.0 63894.0 55202.0 59753.0 62254.0 49782.0 61284.0 True False 58484.40082941931 59399.208206921205 58700.56972288089 58802.203765799946 55867.06450039266 62805.574426136554 62531.63289832331 62435.148833295476 59739.79102529759 59514.571685045536 0.9826904432568557 0.9980615927350559 0.9863226443689725 0.9880303613203254 0.9387123677213761 1.0552974279728868 1.0506944959504074 1.049073312057185 1.0037842722189774 1.0 15.860955324002704 -6.776670912157204 24.99976486146079 1.03601977457625 0.9807703723262706 0.5684357249776988 0.022910725734121274 173.5364318970726 284826.41868659446 0.00805853264184818 0.007133465738894853 1.6723573677200957e-07 6.776670912157204 -0.05524940224997943 NIGRDT(ph)PTSAGPNSFNK ddPTM_A459_Selumetinib_30min_R1 4 NIGRDTPTSAGPNSFNK 17 1 Q8WW12;Q8WW12-3 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 NIGRDT(0.448)PT(0.448)S(0.105)AGPNSFNK;NIGRDT(0.999)PT(0.001)SAGPNSFNK;NIGRDT(0.996)PT(0.003)S(0.001)AGPNSFNK;NIGRDT(0.929)PT(0.024)S(0.047)AGPNSFNK 197.75 7.9018e-07 81686700.0 6934.400000000001 7554.1 7952.4 7262.7 7394.5 6590.3 7531.0 6786.4 3911.69 5593.599999999999 True False 7095.95802800644 6669.662460194187 6872.507759406388 5994.405782763691 6725.668780605005 6524.007565513635 6962.9306067571115 6606.402626666076 6637.852231466166 6311.593046277968 1.1242736938166542 1.0567320185713458 1.0888705448871103 0.9497452923234132 1.065605581869893 1.0336546601908896 1.1031970147161574 1.0467092187703644 1.0516920502947504 1.0 12.623788472104104 -1.5228798523582339 0.006270559561254475 4.620046361575204e-08 2.1890798509947524 0.14622831691650584 0.04425187068210648 78762.78617145539 38.32137441178955 6094.7973393765615 7336.6225260254905 0.029999923525865647 1.5228798523582339 2.189079804794289 NIGRDT(ph)PTSAGPNSFNK ddPTM_A459_Selumetinib_30min_R2 1 NIGRDTPTSAGPNSFNK 17 1 Q8WW12;Q8WW12-3 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 NIGRDT(0.759)PT(0.229)S(0.012)AGPNSFNK 86.439 0.015471 90039000.0 35788.0 34147.0 43957.0 41047.0 36524.0 29937.0 33878.0 30071.0 26647.0 35915.0 True False 33799.046230715016 36765.96510008952 41128.85447676294 35456.3277899755 31935.528591297178 34060.5500089716 35453.394127983476 30158.50163147795 31977.14457938822 34878.04063162343 0.9690637896691334 1.0541293155887412 1.1792191800898353 1.0165802650573135 0.9156342504613543 0.9765614521960668 1.016496153050478 0.8646845145347316 0.9168274364126691 1.0 15.090031374640223 -6.003829835818046 24.98939635018068 0.9482076313278875 1.0714304716946446 0.4234048112621436 0.06290328836510564 154.5490894073179 1008436.4840443757 0.018525741784686002 0.026819445456220944 9.912202462636537e-07 6.003829835818046 0.12322284036675701 NIGS(ph)DFIPR ddPTM_A459_Selumetinib_30min_R1 2 NIGSDFIPR 9 0 Q5T853;Q5T857;P41279-2;P41279 Q5T853 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 1 NIGS(1)DFIPR;NIGS(1)DFIPR 103.21 0.01544 12983800.0 5547.9 8258.2 6781.1 8200.8 6153.1 7119.299999999999 6861.0 6082.0 3431.5 5402.1 True False 5677.155275665798 7291.326104866975 5860.263865916039 6768.684228081629 5596.553191418037 7047.686305807208 6343.469246177214 5920.685602879743 5823.004873156144 6095.512155910011 0.9313664103124482 1.1961794051706618 0.9614063127138739 1.1104373274883772 0.9181432254206566 1.1562090478277531 1.0406786310854605 0.9713188082381623 0.9552937840523125 1.0 12.573531728436114 -7.7388966321860195 5.972466346810114 0.9720680125045745 1.049789769857721 0.11485919349842666 0.08757754673235636 0.3184133960274641 36.1517296082244 0.04076434515551607 0.022037721050712805 1.8243298652157343e-08 7.7388966321860195 0.07772175735314646 NIHLNLDR ddPTM_A459_Selumetinib_30min_R2 2 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 ; 123.35 0.008363500000000001 1948000.0 38823.0 33162.0 38813.0 32104.0 35862.0 30069.0 30746.0 34128.0 26031.0 38959.0 False True 36665.37308078265 35705.418767363684 36315.81383639918 27731.37981751097 31356.694949652236 34210.731810794896 32175.749922043207 34227.30682980547 31237.92736691018 37834.15244236162 0.9691078222682655 0.9437351298343223 0.9598685709089017 0.7329721436143785 0.8287933764981928 0.9042288409371184 0.8504419379041542 0.9046669376814772 0.8256542132006142 1.0 15.207401505903409 NIIEATHMYDNAAEACSTTEEVFNS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 NIIEATHMYDNAAEACSTTEEVFNSPR 27 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 NIIEATHMY(0.001)DNAAEACS(0.001)T(0.006)T(0.001)EEVFNS(0.992)PR;NIIEATHMYDNAAEACS(0.013)T(0.095)T(0.269)EEVFNS(0.623)PR;NIIEATHMYDNAAEACST(0.001)T(0.003)EEVFNS(0.996)PR;NIIEATHMYDNAAEACSTTEEVFNS(1)PR 218.1 1.2459e-44 153354500.0 5043.139999999999 5982.280000000001 6283.66 6786.630000000001 5743.04 4944.63 5589.700000000001 5233.24 2792.91 4692.14 True False 5160.635349757784 5281.871876513479 5430.373485673704 5601.472471322997 5223.583046016064 4894.8915115648315 5168.064428706711 5094.43747524077 4739.364283924381 5294.421874313984 0.9747306641344037 0.9976295810763794 1.0256782732066163 1.057995113403916 0.9866201013104763 0.9245374901672487 0.9761338539680227 0.9622273396754719 0.8951618130239153 1.0 12.370257442043776 -6.534496940039126 9.096499775314522 0.9512442409477354 1.0147621884010807 0.4446679287433185 0.03295505399823287 0.1620549591189892 102.08910210346357 0.010838113757960762 0.01104300237587969 2.92080833962532e-07 6.534496940039126 0.06351794745334527 NIIEATHMYDNAAEACSTTEEVFNS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 NIIEATHMYDNAAEACSTTEEVFNSPR 27 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 NIIEATHMYDNAAEACS(0.144)T(0.144)T(0.144)EEVFNS(0.569)PR 59.942 0.0098335 2939800.0 6536.9 5524.3 4945.8 7601.9 7436.9 6457.1 4958.8 5385.1 4908.4 7685.3 True False 6173.605267284033 5947.996046575816 4627.592612579887 6566.508105991053 6502.610135270451 7346.506913282247 5189.3940256757905 5400.769749448705 5890.217152154813 7463.405420192558 0.8271834262923844 0.7969547025387715 0.6200376841461325 0.8798273356858101 0.8712658323072421 0.9843371088224636 0.6953118226213018 0.7236334414899523 0.7892130764086033 1.0 12.865618341657312 -11.282989159312345 2.4217624042762744 1.0529800338065327 0.7980782675998311 0.27653433692601115 0.09770367198616613 17952932.920958254 12276273.699101647 5664243.99723429 0.02785103559507448 5.212077211243745e-12 11.282989159312345 -0.2549017662067016 NIIGSS(ph)PVADFSAIK ddPTM_A459_Selumetinib_30min_R1 2 NIIGSSPVADFSAIK 15 0 B1AUU8;P42566 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 NIIGS(0.038)S(0.932)PVADFS(0.03)AIK;NIIGS(0.036)S(0.964)PVADFSAIK 214.28 3.570000000000001e-07 61451000.0 10572.2 13188.7 10949.5 10773.1 10746.0 10372.1 11845.7 10469.3 5798.9 9570.8 True False 10818.511690079837 11644.560872739714 9462.618041298263 8891.780321132845 9774.026197360396 10267.766091113303 10952.169311972211 10191.620154920893 9840.309765101314 10799.305407486627 1.0017784738803568 1.0782694287604009 0.8762246907785658 0.8233659467551137 0.9050606338611874 0.9507802311058974 1.0141549755949686 0.9437292279793795 0.9111983959893858 1.0 13.398650903290047 -10.093630273195892 15.303164755340665 0.9999958496731278 0.944272681765415 0.05361439838596338 0.06933158270887968 0.0 0.0 0.07409961056116088 0.017971795362400015 8.060643738909022e-11 10.093630273195892 -0.05572316790771281 NIIGSS(ph)PVADFSAIK ddPTM_A459_Selumetinib_30min_R2 2 NIIGSSPVADFSAIK 15 0 B1AUU8;P42566 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 NIIGS(0.039)S(0.961)PVADFSAIK;NIIGS(0.016)S(0.977)PVADFS(0.007)AIK 224.67 5.0957e-10 24170000.0 90674.0 78650.0 88615.0 96981.0 94275.0 71848.0 87276.0 81075.0 64310.0 86557.0 True False 85634.70207678148 84682.20210039048 82913.60737671674 83772.02049844347 82431.33167080663 81744.40982879348 91334.50693411312 81310.91482731112 77173.79697153353 84057.87450790568 1.0187588322701104 1.0074273540241143 0.986387151258728 0.9965993190865737 0.9806497267909614 0.9724777161847624 1.086566933423032 0.9673206145566265 0.9181031214901264 1.0 16.35909535643343 -7.982378850499341 24.999960246225555 0.953604936298544 1.0051439255135275 0.25631571012507415 0.03510703721746149 280.9593402440549 398610.18634075235 0.018853253554062234 0.009053912180276695 1.0414085753550618e-08 7.982378850499341 0.051538989214983455 NIIHGS(ph)DSVESAEK ddPTM_A459_Selumetinib_30min_R1 2 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 1 NIIHGS(0.966)DS(0.033)VES(0.001)AEK;NIIHGS(0.804)DS(0.058)VES(0.138)AEK 187.56 7.7435e-05 69577000.0 12713.6 12993.8 10364.4 11293.400000000001 12064.2 13840.6 13246.5 13498.599999999999 5752.700000000001 11648.9 True False 13009.80214364078 11472.479855346264 8956.971407574014 9321.219693373458 10972.99524010751 13701.376130259323 12247.305840181669 13140.57327836772 9761.91173941581 13144.149784894775 0.9897789021387761 0.8728202312887829 0.6814416720864931 0.7091534900253025 0.8348197045591834 1.0423934871774598 0.9317685845497776 0.9997279012651571 0.742681109023436 1.0 13.682133205355859 -6.573755781635673 10.631870125203594 0.9422948312746321 0.8036246738817927 0.24779661495459193 0.10949904847809543 0.7298351679789934 148.78587553376184 0.03749328214741126 0.03749934020814512 2.668358750396801e-07 6.573755781635673 -0.1386701573928394 NIIHGS(ph)DSVESAEK ddPTM_A459_Selumetinib_30min_R2 4 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 1 NIIHGS(0.859)DS(0.141)VESAEK;NIIHGS(0.929)DS(0.071)VESAEK;NIIHGS(0.983)DS(0.017)VES(0.001)AEK;NIIHGS(0.793)DS(0.207)VESAEK 160.09 0.00019405 116970000.0 568943.0 452710.0 517808.0 476500.0 545069.0 535405.0 511004.0 506580.0 371312.0 629801.0 True False 537323.4257192821 487431.4013079193 484492.79702672176 411599.87799165136 476592.5592413135 609152.1788273191 534766.6985352166 508054.063931167 445584.77532411914 611617.0087104851 0.8785292398132595 0.7969552748959762 0.7921506271518051 0.6729699667107953 0.7792336584068303 0.9959699781921324 0.874348964988241 0.8306735370265993 0.7285356178428992 1.0 19.22226900219679 -6.61040792472516 24.99999582153602 0.8760464015986512 0.7789082709765571 0.252180849799445 0.08672691306977617 34.677128816930455 9897.219409746966 0.029480867449426993 0.029480868109034126 2.4524043357736204e-07 6.61040792472516 -0.09713813062209409 NIIHGS(ph)DSVK ddPTM_A459_Selumetinib_30min_R1 1 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 NIIHGS(0.739)DS(0.261)VK 72.681 0.044614 8090800.0 5973.7 5323.4 6568.7 7312.2 7035.6 6041.0 6707.2 6169.3 2528.1 4614.4 True False 6112.875587203229 4700.133853218481 5676.706619286347 6035.261536993768 6399.231222236069 5980.233024789141 6201.270504002302 6005.67012328938 4290.001054881548 5206.703188062263 1.1740395729141244 0.9027082365660434 1.0902689118714681 1.1591330097001098 1.2290370683906067 1.1485642274559456 1.191016710578077 1.1534496794553144 0.8239380851817143 1.0 12.34615445184433 -8.250932485759103 24.903129952800782 0.9119690417974298 1.1288460199887949 0.47160059072527627 0.09272688360814862 543.652847361038 1288558.1015402894 0.06782754554392273 0.025023766676574334 5.611352018071508e-09 8.250932485759103 0.2168769781913651 NIIHGS(ph)DSVK ddPTM_A459_Selumetinib_30min_R2 2 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 NIIHGS(0.553)DS(0.447)VK;NIIHGS(0.823)DS(0.177)VK 141.37 0.0013161 64476000.0 475500.0 410850.0 394300.0 378800.0 417430.0 339630.0 365990.0 333150.0 225358.0 403910.0 True False 449073.6135773161 442360.8739090331 368931.16728138 327206.7865335519 364988.71152845153 386410.94964582386 383009.2601954265 334119.4113440483 270435.8970286252 392248.06881578837 1.1448714455958602 1.127757939623609 0.9405557263677473 0.8341832950800788 0.9305048017963891 0.985118807117172 0.9764465159809348 0.851806389647162 0.6894511879818332 1.0 18.58140681871943 -5.296856825227442 3.6251622637334973 0.8971796127722615 1.1431835412152367 0.5458726772467515 0.0866619751609863 0.17409428178796968 4.838849053372939 0.024254987465300522 0.061573179373626705 5.048276977390036e-06 5.296856825227442 0.24600392844297514 NIIHGSDS(ph)VESAEK ddPTM_A459_Selumetinib_30min_R1 1 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 1 NIIHGS(0.029)DS(0.943)VES(0.029)AEK 200.33 7.1493e-05 7636000.0 3533.0 3746.6 2792.9 3180.0 4338.9 3498.4 4830.1 4224.1 924.02 2296.9 True False 3615.3120259787056 3307.9463302529143 2413.639520301558 2624.6726959930243 3946.4472610950147 3463.209272293054 4465.76166826418 4112.0631461894645 1567.9944522493765 2591.7294887006356 1.394941887932619 1.2763470665726593 0.9312852791251903 1.0127108972738141 1.522708013432979 1.3362541451150194 1.7230817057620822 1.586609699861481 0.6049992713689772 1.0 11.33969942970703 -6.254360218917787 24.912298194704615 1.348345203353213 1.1466777055305042 0.02914845131668109 0.32317856439557946 1531.4743577056963 5389412.217359159 0.097614094170551 0.12336689193450838 5.567237913399898e-07 6.254360218917787 -0.20166749782270887 NIIHGSDS(ph)VESAEK ddPTM_A459_Selumetinib_30min_R2 2 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 1 NIIHGSDS(0.998)VES(0.002)AEK;NIIHGS(0.008)DS(0.965)VES(0.027)AEK 212.59 2.6711e-06 16858700.0 95915.0 63867.0 85162.0 99538.0 131687.0 108001.0 91656.0 103734.0 92680.0 111551.0 True False 90584.42827816682 68765.39353522753 79682.76963737466 85980.75268737272 115143.30176328303 122877.15741453532 95918.18561291855 104035.84876591193 111218.5896955642 108330.23278569488 0.8361878854019096 0.63477564634485 0.7355543100789574 0.7936912021362015 1.062891667472608 1.1342831475089508 0.8854239776505367 0.9603583975649868 1.026662519184125 1.0 16.72507640069938 -6.1354847316807115 4.169533058839711 1.0088792170546648 0.7305704669411175 0.7416314252867656 0.07600628263944742 0.1222759933516386 3.5578208295345783 0.023983193096801036 0.031696420683092724 7.320070576299725e-07 6.1354847316807115 -0.2783087501135473 NIIHGSDS(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 NIIHGS(0.264)DS(0.736)VK 136.24 0.0018769 67046000.0 5801.8 4621.9 6021.1 6684.5 5290.4 5396.8 4595.7 5317.1 3279.8 4636.1 True False 5936.9706516624 4080.7657993369844 5203.467691534859 5517.177558605458 4811.8842540959795 5342.51309190234 4249.042648980702 5176.073235625102 5565.581052885769 5231.188594438159 1.1349181059873532 0.7800838615674622 0.9947008404681159 1.054669977769749 0.9198453023108386 1.021280918371504 0.8122518567765493 0.9894640849172105 1.0639228451452005 1.0 12.352923067554316 -8.002648801772873 24.999412879010602 1.030205461181287 0.9544839148981515 0.07320792319446612 0.10127555854740156 246.89402522494768 2330169.9363503894 0.05430487048908073 0.025328862294921265 9.939194702262268e-09 8.002648801772873 -0.07572154628313543 NIIHGSDS(ph)VK ddPTM_A459_Selumetinib_30min_R2 5 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 NIIHGS(0.077)DS(0.923)VK;NIIHGS(0.226)DS(0.774)VK;NIIHGS(0.007)DS(0.993)VK;NIIHGS(0.033)DS(0.967)VK;NIIHGS(0.02)DS(0.98)VK 166.6 0.00032123 79265000.0 490829.0 397835.0 442546.0 524863.0 502850.0 399472.0 413602.0 448778.0 312316.0 499304.0 True False 463550.68912416487 428347.66525885544 414073.07216765365 453375.75396082335 439677.4874639633 454495.6419542346 432835.31253681454 450083.8696808024 374787.92683815095 484887.7961724098 0.9559957845574275 0.8833954342429964 0.8539564728917681 0.9350116821657812 0.9067612980460097 0.9373212638922166 0.892650456360244 0.9282227212845087 0.7729374296417412 1.0 18.887291418368818 -10.211892495371048 12.847444573399287 0.9999990483961412 0.8981199105332826 0.27785745037705645 0.05009591438934034 0.0 0.0 0.046466907500542075 0.011269880454149443 6.139139537311013e-11 10.211892495371048 -0.10187913786285863 NIIS(ph)PPWDFR ddPTM_A459_Selumetinib_30min_R1 2 NIISPPWDFR 10 0 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 NIIS(1)PPWDFR;NIIS(1)PPWDFR 107.17 0.011456 28231000.0 5508.299999999999 7437.3 6096.4 6023.7 6338.7 5161.8 6515.9 6008.6 3633.5 5313.4 True False 5636.632672713987 6566.537458493033 5268.542365128154 4971.773873853202 5765.365704188382 5109.876978539413 6024.400417018811 5849.232409316543 6165.784119659864 5995.426646898844 0.9401553892131355 1.0952577431482042 0.8787602076414907 0.8292610629178274 0.9616272608673375 0.8522958047001568 1.0048326452521863 0.9756157074062577 1.0284145704374745 1.0 12.549646707102882 -7.371927272557222 24.05605443248562 1.0001861166469965 0.928908288331636 0.2211194833991913 0.06971755323331696 35.10541251821222 7608.903291300716 0.030979307247102163 0.0208862414566746 4.246906771706243e-08 7.371927272557222 -0.07127782831536056 NIIS(ph)PPWDFR ddPTM_A459_Selumetinib_30min_R2 3 NIISPPWDFR 10 0 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 NIIS(1)PPWDFR;NIIS(1)PPWDFR;NIIS(1)PPWDFR 108.56 0.010603 8115520.0 62296.9 49490.6 70097.9 65430.6 67387.7 53406.8 66380.2 63890.0 51143.0 60647.6 True False 58834.68769224967 53286.369882639425 65587.87743082271 56518.839405919294 58921.85467231833 60763.10192133966 69467.01082987103 64075.90932244111 61373.02905481489 58896.54620661131 0.9989497089668953 0.9047452408450034 1.1136116063705666 0.9596290962062372 1.000429710523572 1.0316921081956214 1.1794751187306998 1.0879400143033922 1.0420480148278302 1.0 15.845895414000935 -7.011060481409569 18.911400310925682 1.0876784209282113 0.997109840154586 0.2574474484545637 0.06459058382458227 26.7965161686684 45817.318252310855 0.02332337776994746 0.019219287653244307 9.748538666124066e-08 7.011060481409569 -0.09056858077362528 NILVQTPESES(ph)PQSHR ddPTM_A459_Selumetinib_30min_R2 2 NILVQTPESESPQSHR 16 0 Q9C026-5;Q9C026;Q9C026-4 Q9C026-5 TRIM9 E3 ubiquitin-protein ligase TRIM9 1 NILVQTPES(0.002)ES(0.586)PQS(0.412)HR;NILVQTPES(0.401)ES(0.548)PQS(0.051)HR 183.39 5.7706e-07 26686000.0 132591.0 120113.0 135035.0 159763.0 145328.0 98001.0 115295.0 114531.0 97302.0 131905.0 True False 125222.12302382728 129325.28087583228 126346.99511499121 138003.00379345258 127070.59739119564 111499.74818549702 120656.44595270822 114864.26624837217 116765.11884503471 128096.5599196515 0.9775603896183691 1.0095921464007425 0.9863418283382653 1.0773357526542078 0.9919907097497436 0.870435148730264 0.9419179252619267 0.8967006320889548 0.9115398486756832 1.0 16.96687220652933 -6.60805585459648 6.820770393409905 0.9192099885627998 1.0134911503104413 0.5277186636936868 0.04016289719483318 0.15779024913764392 10.48595150058512 0.012753946212521447 0.012745867880146694 2.4657222004047004e-07 6.60805585459648 0.09428116174764156 NILVQTPESESPQS(ph)HR ddPTM_A459_Selumetinib_30min_R2 1 NILVQTPESESPQSHR 16 0 Q9C026-5;Q9C026;Q9C026-4 Q9C026-5 TRIM9 E3 ubiquitin-protein ligase TRIM9 1 NILVQTPES(0.06)ES(0.298)PQS(0.642)HR 92.679 0.007012999999999999 2473700.0 19035.0 18059.0 17795.0 24423.0 20722.0 12048.0 14773.0 17661.0 15915.0 17442.0 True False 17977.11090314239 19444.06723116281 16650.089073731047 21096.54526797503 18118.71710296956 13707.502639145203 15459.973772144156 17712.390586064066 19098.444702254055 16938.404140241582 1.0613225870808627 1.1479279317092437 0.9829786168683053 1.2454860028905972 1.0696826544552587 0.8092558499404007 0.9127172574312931 1.045694177527839 1.1275232627659848 1.0 14.048010336426527 -6.538006391447937 24.996561738473268 0.9734956286811844 1.1099513151482836 0.28126847371665176 0.09930107443441331 316.1171225766841 522340.7902847131 0.03400469245961857 0.03401617392823791 2.897300948236156e-07 6.538006391447937 0.13645568646709916 NINDDFEMIDCDLEDAT(ph)KTPDCSSGPVKEER ddPTM_A459_Selumetinib_30min_R1 1 NINDDFEMIDCDLEDATKTPDCSSGPVKEER 31 2 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 NINDDFEMIDCDLEDAT(0.497)KT(0.497)PDCS(0.005)S(0.001)GPVKEER 88.595 1.149e-06 5405500.0 602.94 729.17 810.87 758.98 525.67 493.83 494.93 604.76 306.9 288.64 True False 616.9873288829896 643.7984374180638 700.758307790084 626.4383908191149 478.1232413145762 488.8625185617649 457.5970316295707 588.7198002626687 520.7868849108607 325.6897555916894 1.8944020138493212 1.9767230204967847 2.151612986773248 1.92342061751696 1.4680327922686938 1.501006740828047 1.4050089810109065 1.8076092052484904 1.5990275284057773 1.0 8.347354530971526 -6.201347623518127 4.530263078589477 1.5019890980475434 2.0073038923531983 0.6179598329473486 0.20056929563671613 0.15454732772419993 6.54911492179014 0.059360311100381785 0.07658425725930187 6.290025071103577e-07 6.201347623518127 0.5053147943056548 NINDDFEMIDCDLEDATKT(ph)PDCSSGPVKEER ddPTM_A459_Selumetinib_30min_R1 1 NINDDFEMIDCDLEDATKTPDCSSGPVKEER 31 2 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 NINDDFEMIDCDLEDAT(0.236)KT(0.721)PDCS(0.014)S(0.029)GPVKEER 51.386 0.015135 5688100.0 1324.8 1586.5 1885.8 2171.5 1199.5 1492.9 1103.3 1052.8 783.28 1130.4 True False 1355.665262387939 1400.7518424561592 1629.7187179579207 1792.2882891034128 1091.0054367889254 1477.8827814447466 1020.0771927280745 1024.8763240236426 1329.168951492275 1275.497851028428 1.0628518592131477 1.098200080326862 1.277711849254694 1.4051676274156786 0.85535654639422 1.1586713221454168 0.799748264495774 0.803510819871072 1.0420785502857353 1.0 10.316844752937445 -6.277334990262165 24.989638914756718 0.9370013395834514 1.2076933092992996 0.48237811660704544 0.13577120102877818 732.7953839200402 1152031.753265679 0.04395311117880303 0.04999669393084942 5.280377960851176e-07 6.277334990262165 0.2706919697158482 NINMDNDLEVLTS(ph)SPTR ddPTM_A459_Selumetinib_30min_R1 3 NINMDNDLEVLTSSPTR 17 0 Q9Y5T5-4;Q9Y5T5-3;Q9Y5T5-2;Q9Y5T5 Q9Y5T5-4 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 NINMDNDLEVLT(0.05)S(0.433)S(0.433)PT(0.084)R;NINMDNDLEVLTS(0.684)S(0.316)PTR;NINMDNDLEVLTS(0.916)S(0.084)PTR 281.65 8.409499999999997e-64 85398800.0 7408.1 7555.3 9509.1 8957.7 8626.9 7399.2 7963.700000000001 7213.799999999999 4815.200000000001 6607.7 True False 7580.694316346688 6670.72196363632 8217.816449747414 7393.405851854313 7846.5984182029 7324.770765936072 7362.991697388348 7022.46659027522 8171.042711706675 7455.862659448469 1.0167427516573184 0.8946948553542391 1.1021952556131591 0.9916231279401309 1.052406512378453 0.9824176088669941 0.9875439011819204 0.9418717740697616 1.0959218382800937 1.0 12.864159569767274 -5.244886386756066 24.999924775944226 1.0149215408450214 0.9557188241705654 0.16935182717991548 0.055622388723999695 1487.8015178979042 2247013.5213174834 0.01346375023546439 0.03541386436277206 5.6900176460494655e-06 5.244886386756066 -0.05920271667445598 NINMDNDLEVLTS(ph)SPTR ddPTM_A459_Selumetinib_30min_R2 1 NINMDNDLEVLTSSPTR 17 0 Q9Y5T5-4;Q9Y5T5-3;Q9Y5T5-2;Q9Y5T5 Q9Y5T5-4 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 NINMDNDLEVLT(0.055)S(0.605)S(0.339)PTR 105.02 0.0047408 0.0 8721.4 6403.3 6268.5 5590.4 8461.7 6405.7 7012.2 6724.7 6027.2 8551.5 True False 8236.699502530399 6894.412520145344 5865.191534626758 4828.977876022094 7398.66559744221 7288.027029844987 7338.281194410696 6744.267763665984 7232.808414038683 8304.595975534676 0.9918242292335112 0.8301924067656357 0.706258504556465 0.5814825778699234 0.8909121670986361 0.8775895963290088 0.8836409641154439 0.8121126883878016 0.8709404329056493 1.0 13.01969426642335 NINMDNDLEVLTSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 3 NINMDNDLEVLTSSPTR 17 0 Q9Y5T5-4;Q9Y5T5-3;Q9Y5T5-2;Q9Y5T5 Q9Y5T5-4 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 NINMDNDLEVLT(0.002)S(0.139)S(0.53)PT(0.329)R;NINMDNDLEVLTS(0.226)S(0.774)PTR;NINMDNDLEVLTS(0.081)S(0.917)PT(0.002)R 265.93 3.2523e-41 81749300.0 5827.700000000001 7768.599999999999 8286.9 8657.3 7144.799999999999 6669.3 6987.5 6552.6 3879.5699999999997 5841.7 True False 5963.474071269777 6859.0487004758415 7161.584496683372 7145.46507264792 6498.5541015168965 6602.212897239897 6460.427249331472 6378.803762155506 6583.346937418147 6591.539097976616 0.9047164831504019 1.040583784533925 1.0864813801805016 1.0840359082207889 0.9858932799946126 1.0016193182054487 0.9801090691117358 0.9677259995489653 0.9987571703001832 1.0 12.686399652742933 -6.3869254717273805 21.517373874973224 0.9875833445195347 1.0340389861880876 0.1392422334255733 0.047902298400446755 10.34763502230946 1733.881143365669 0.015549160147041522 0.017631065792191272 4.1027450320539703e-07 6.3869254717273805 0.04645564166855298 NINMDNDLEVLTSS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 4 NINMDNDLEVLTSSPTR 17 0 Q9Y5T5-4;Q9Y5T5-3;Q9Y5T5-2;Q9Y5T5 Q9Y5T5-4 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 NINMDNDLEVLT(0.001)S(0.207)S(0.784)PT(0.009)R;NINMDNDLEVLT(0.005)S(0.246)S(0.744)PT(0.005)R;NINMDNDLEVLT(0.007)S(0.272)S(0.72)PT(0.002)R;NINMDNDLEVLT(0.009)S(0.237)S(0.709)PT(0.045)R 136.85 0.00051295 43510900.0 108983.0 121559.0 118087.0 131583.0 127327.0 98072.0 114832.0 103469.0 87688.0 120592.0 True False 102926.16115351558 130882.18442620932 110489.4109834045 113661.1684066642 111331.04394217767 111580.52779102327 120171.91553529118 103770.07765978493 105228.0502074304 117110.19562435546 0.8788830093296334 1.1175985466374687 0.9434653438528281 0.970548873227448 0.9506520192254218 0.9527823533736615 1.0261439227781375 0.8860891838370717 0.8985387621156536 1.0 16.837507156906057 -6.539552172384465 0.7249655652758197 0.9397345619355757 0.9914971994886345 0.024745869174415347 0.06777188838292625 2.1701495575880796 2.540978709402716 0.044414174738818125 0.05681378089082612 2.88700693830144e-07 6.539552172384465 0.051762637553058766 NINPSTANS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 NINPSTANSPK 11 0 P46937-6;P46937-7;P46937;P46937-9;H0YCI3;P46937-4 P46937-6 YAP1 Transcriptional coactivator YAP1 1 NINPS(0.012)T(0.042)ANS(0.946)PK;NINPS(0.016)T(0.142)ANS(0.841)PK 130.66 0.0023519 14394100.0 5406.7 5981.0 7475.0 7392.1 4706.200000000001 5181.0 5271.9 5442.7 3896.2799999999997 5446.799999999999 True False 5532.665590393171 5280.741739508535 6459.936057235903 6101.208501902527 4280.525040947097 5128.883843971617 4874.23633856896 5298.341915618801 6611.702586968029 6145.949836324875 0.9002132685322352 0.8592230460940903 1.05108831495097 0.9927201920591818 0.6964790073045478 0.834514433173207 0.7930810482312091 0.8620867492773221 1.0757820618532192 1.0 12.585420276262555 -8.255661873212931 24.67704190821287 1.0378910364209648 0.8731774693890169 0.3265068473881281 0.09433741300527256 458.726260162831 1959348.738723005 0.07378256111104901 0.0262243744421469 5.550576936549067e-09 8.255661873212931 -0.16471356703194795 NINPSTANS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 NINPSTANSPK 11 0 P46937-6;P46937-7;P46937;P46937-9;H0YCI3;P46937-4 P46937-6 YAP1 Transcriptional coactivator YAP1 1 NINPST(0.001)ANS(0.999)PK;NINPSTANS(0.999)PK 144.88 0.00072087 20976800.0 84058.0 96471.0 83983.0 75411.0 74675.0 54451.0 72859.0 64467.0 41837.0 70680.0 True False 79386.39287083491 103870.01549684422 78579.6252137765 65139.891708768955 65293.65889702984 61951.1309930358 76247.08786736964 64654.58829691365 50205.56902344977 68639.28475130557 1.1565737195320194 1.513273570276656 1.1448199889973627 0.9490176353786953 0.9512578566866243 0.9025608471518555 1.110837447441778 0.9419472905519148 0.7314407369679768 1.0 16.06674689900811 -5.567109531802401 3.61679910887652 0.9452339058612641 1.337544989107616 0.6356929383566842 0.1199661232856913 0.13188087165592977 3.5847393092123214 0.03246277903947297 0.06314075755189473 2.7095081906872045e-06 5.567109531802401 0.392311083246352 NINTFVET(ph)PVQK ddPTM_A459_Selumetinib_30min_R1 3 NINTFVETPVQK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 NINTFVET(1)PVQK;NINT(0.001)FVET(0.999)PVQK;NINT(0.001)FVET(0.999)PVQK 185.95 0.00025076 28501300.0 4427.5 7130.4 5643.0 6676.700000000001 5606.3 5139.9 6536.3 5581.7 3055.46 4686.1 True False 4530.652135584691 6295.569453166969 4876.711594780227 5510.739682181326 5099.211154872655 5088.197272655804 6043.261628594678 5433.655184083174 5184.892458031083 5287.606581479402 0.8568436523726912 1.190627433443725 0.9222909306190832 1.0421992629866752 0.9643703774659355 0.9622874157237686 1.1429106034026937 1.0276209283639461 0.9805745526136362 1.0 12.368399123371661 NINTFVET(ph)PVQK ddPTM_A459_Selumetinib_30min_R2 2 NINTFVETPVQK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 NINTFVET(1)PVQK;NINTFVET(1)PVQK 111.72 0.015623 40463000.0 110941.0 104295.0 117281.0 112438.0 103164.0 95226.0 98509.0 101726.0 77377.0 128189.0 True False 104775.34335201053 112294.09113871884 109735.26814589789 97123.75043363146 90203.6160221383 108342.5171244389 103089.86369188044 102022.00581835404 92854.56209401901 124487.85049497939 0.8416511566021146 0.9020485990578468 0.8814937980660493 0.7801865808386537 0.724597747197637 0.8703059510920576 0.8281118461117463 0.8195338373399628 0.745892564815101 1.0 16.925645422465536 -5.742798419061162 24.60123521433507 0.8145181243943064 0.8777629687471419 0.08207965909358095 0.07321702586091196 408.21320492181496 538730.1201503973 0.018958639504307727 0.0327561178369516 1.8080131337109692e-06 5.742798419061162 0.0632448443528355 NIPCAAVS(ph)PNR ddPTM_A459_Selumetinib_30min_R2 2 NIPCAAVSPNR 11 0 Q13118-2;Q13118 Q13118-2 KLF10 Krueppel-like factor 10 1 NIPCAAVS(1)PNR;NIPCAAVS(1)PNR 105.99 0.011377 40599000.0 91553.0 71439.0 90467.0 93934.0 87676.0 76422.0 84128.0 84960.0 74662.0 88262.0 True False 86464.85077569718 76918.14158741024 84646.45171302222 81140.02715481164 76661.35704661503 86948.43681015568 88040.11869646938 85207.21953411486 89596.48623058086 85713.64672778342 1.0087641125607396 0.8973850083837095 0.987549298676435 0.9466407071968708 0.8943891664075686 1.0144059916887425 1.0271423753101365 0.9940916386946304 1.0453001319046533 1.0 16.38723729799593 -6.8460128199226995 10.83585078818209 1.0166927113443174 0.9464624972975345 0.491314310697175 0.0352276588816792 0.3520341927679354 42.7494204093942 0.011798977574145306 0.010408091313616382 1.4255655117656302e-07 6.8460128199226995 -0.07023021404678287 NIPS(ph)PGQLDPDTR ddPTM_A459_Selumetinib_30min_R1 1 NIPSPGQLDPDTR 13 0 Q9P2D1 Q9P2D1 CHD7 Chromodomain-helicase-DNA-binding protein 7 1 NIPS(1)PGQLDPDTR 147.83 0.00056279 11521000.0 3531.4 4504.7 2749.6 3066.7 3282.1 3321.0 4048.6 3421.8 1747.5 3119.3 True False 3613.674749091764 3977.287629821784 2376.2194224716827 2531.158414088616 2985.2346345018177 3287.5937552267396 3743.210842453438 3331.0427484271463 2965.3798676498204 3519.6925395550024 1.0267018236623144 1.1300099611327514 0.6751213055592947 0.7191419095966356 0.84815210446741 0.9340570854641732 1.0635050648278201 0.9464016276968024 0.8425110529753078 1.0 11.781233693344927 -6.929448713295132 5.916110890227939 0.9640255184208919 0.8741614141610601 0.07937511688150511 0.13392847837229085 0.6007420166438763 37.4190895337037 0.05313618324067533 0.046653910479903485 1.1763898987206307e-07 6.929448713295132 -0.08986410425983182 NIPS(ph)PGQLDPDTR ddPTM_A459_Selumetinib_30min_R2 2 NIPSPGQLDPDTR 13 0 Q9P2D1 Q9P2D1 CHD7 Chromodomain-helicase-DNA-binding protein 7 1 NIPS(0.999)PGQLDPDT(0.001)R;NIPS(0.994)PGQLDPDT(0.006)R 123.1 0.0025195 13727500.0 75930.0 73139.0 82383.0 95748.0 87659.0 57490.0 71678.0 69513.0 55318.0 73821.0 True False 71710.11457187298 78748.52612104868 77082.56747182818 82706.9572254871 76646.49273859702 65408.72565774051 75011.16902726247 69715.27132150337 66383.14571406161 71689.59592000773 1.0002862151976437 1.098465197222166 1.0752266975787952 1.153681453551122 1.0691438800146156 0.9123879806872464 1.0463327079003346 0.9724600958735025 0.9259801908792018 1.0 16.129476139986707 -6.636641727738475 7.2125773608103625 0.9747441853287033 1.086024825267771 0.5451419464687645 0.04926748368953819 0.17378518942177273 10.332208416947163 0.016170123101013224 0.01614625698175139 2.3086509304173598e-07 6.636641727738475 0.11128063993906778 NIPS(ph)PGQLDPDTRIPVINLEDGTR ddPTM_A459_Selumetinib_30min_R1 2 NIPSPGQLDPDTRIPVINLEDGTR 24 1 Q9P2D1 Q9P2D1 CHD7 Chromodomain-helicase-DNA-binding protein 7 1 NIPS(0.885)PGQLDPDT(0.114)RIPVINLEDGT(0.001)R;NIPS(0.512)PGQLDPDT(0.465)RIPVINLEDGT(0.023)R 75.73 0.00024664 6882900.0 2167.7 1781.21 4704.1 4358.1 3145.8 2447.3 2266.7200000000003 2037.7599999999998 1286.8200000000002 1487.47 True False 2218.2031923900495 1572.6651051379374 4065.3090577716953 3597.039646668929 2861.262945436098 2422.6823839706108 2095.7394854532577 1983.711985222661 2183.6395543857748 1678.4012636847635 1.3216167315795535 0.9370018595465706 2.4221317903721737 2.143134496200262 1.7047549995014177 1.443446472777226 1.2486522328112821 1.1819056790195797 1.3010235404564763 1.0 10.712871953909552 -7.012611608988862 2.4478916446088133 1.1947538866707395 1.7264529831164332 0.28806346350148104 0.38693972694879936 0.44552372685285146 5.3475618333421515 0.18009966950295106 0.1419588111468097 9.713782857750459e-08 7.012611608988862 0.5316990964456938 NIPSPGQLDPDT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 NIPSPGQLDPDTR 13 0 Q9P2D1 Q9P2D1 CHD7 Chromodomain-helicase-DNA-binding protein 7 1 NIPS(0.212)PGQLDPDT(0.788)R 107.46 0.015454 11247000.0 9920.5 11193.0 13579.0 12885.0 13511.0 9819.9 11812.0 13198.0 10924.0 9781.5 True False 9369.158324908023 12051.467108832452 12705.341923697331 11130.040772135219 11813.62739012747 11172.502088823201 12361.281405033971 13236.403994953474 13109.105242062407 9499.082679610883 0.9863224314299597 1.2686979906702027 1.3375335653166236 1.1716963782224017 1.2436598131190706 1.1761664221329704 1.3013131711724752 1.3934402343254144 1.3800390715832156 1.0 13.213572484687269 -7.275323906069791 22.20858714208979 1.3014848558109182 1.2079008032592689 0.03898791687253844 0.13368402023237486 449.1234155203635 718372.8356624775 0.05395084321629077 0.03666597228115258 5.304886469264771e-08 7.275323906069791 -0.09358405255164937 NISS(ph)SPSVESLPGGR ddPTM_A459_Selumetinib_30min_R1 1 NISSSPSVESLPGGR 15 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 NIS(0.034)S(0.424)S(0.424)PS(0.117)VESLPGGR 249.58 5.3919e-28 34933000.0 3383.9 3638.5 3572.8 4239.1 3561.4 3089.8 3496.1 2808.4 1964.6 2844.4 True False 3462.7382860768016 3212.50272850724 3087.6333839856093 3498.820762762274 3239.271998816237 3058.7194173139364 3232.3863622737417 2733.9121090311505 3333.782711293181 3209.5064468022483 1.0789005547961612 1.0009335646320252 0.962027475302919 1.0901429303088892 1.0092741835878365 0.9530186238951018 1.0071287956110166 0.8518169863017567 1.0387213007827898 1.0 11.648135743537155 -6.640618624829262 4.926647401088279 0.9634240122841807 1.0282717461698714 0.2048815249463647 0.057504938884761 0.3266590715477598 12.723378095764629 0.018761022833834563 0.018679302213771225 2.2876067807053806e-07 6.640618624829262 0.06484773388569065 NISSS(ph)PSVESLPGGR ddPTM_A459_Selumetinib_30min_R2 1 NISSSPSVESLPGGR 15 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 NIS(0.001)S(0.019)S(0.921)PS(0.057)VES(0.002)LPGGR 136.34 0.00040608 9270200.0 29921.0 27271.0 33934.0 37408.0 40832.0 17693.0 26981.0 24057.0 23824.0 28144.0 True False 28258.110603253142 29362.598009914214 31750.723384545636 32312.96586760062 35702.31911728851 20130.05014893726 28235.669961837222 24127.00188714926 28589.465698177864 27331.409593106226 1.03390608182831 1.0743170018322186 1.1616935919965903 1.1822648867605747 1.3062743432850121 0.7365170859689081 1.0330850249655281 0.8827573201067094 1.0460296824715896 1.0 14.738272247041094 -6.7539236139452345 24.999959465244736 0.9381880992149337 1.14964681641004 0.4985142619085726 0.10630692765052 149.43054577508246 497055.5319355572 0.03528059848676209 0.034624299938340736 1.7622859795130657e-07 6.7539236139452345 0.21145871719510623 NISSSPS(ph)VESLPGGR ddPTM_A459_Selumetinib_30min_R1 1 NISSSPSVESLPGGR 15 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 NISS(0.009)S(0.467)PS(0.472)VES(0.052)LPGGR 131.61 0.00069582 9322900.0 1067.3 1314.2 1405.6 1416.9 1440.0 1252.8 1405.3 1301.6 553.55 1258.2 True False 1092.1660133957182 1160.332853044995 1214.7272404081316 1169.4650135070797 1309.7522542526483 1240.1979694513875 1299.2970895864796 1267.0773398073452 939.333920307615 1419.702225905846 0.7692923159987707 0.8173072013778386 0.8556211424075711 0.8237396491795301 0.9225542021087952 0.8735620377435661 0.9151898657885519 0.8924951420702901 0.661641507047909 1.0 10.471372649421255 -4.753568017692435 1.0213670538884927 0.8706681261344439 0.7129993840597574 0.13608414383945555 0.0821196192426826 4.247301972530944 3.4299099761962006 0.026290656109929856 0.747302359888421 1.763729513657388e-05 4.753568017692435 -0.1576687420746865 NISSSPS(ph)VESLPGGR ddPTM_A459_Selumetinib_30min_R2 2 NISSSPSVESLPGGR 15 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 NISS(0.002)S(0.214)PS(0.783)VESLPGGR;NIS(0.32)S(0.142)S(0.083)PS(0.453)VES(0.001)LPGGR 151.73 0.00039571 6111400.0 27433.0 26407.0 28004.0 29011.0 28281.0 14332.3 21921.6 24137.2 17665.6 20274.0 True False 25908.38368300004 28432.331988112077 26202.253128449825 25059.651753233575 24728.087944652136 16306.444229334396 22940.997836826333 24207.43525587144 21199.213618104877 19688.636941821907 1.315905400640832 1.4440985463913514 1.3308312406732394 1.2727976968279986 1.2559573330404403 0.8282160048721718 1.1651897439429073 1.2295130093262507 1.0767232734671568 1.0 14.26507561545409 -6.536703446013302 24.902620590815996 1.0765445172295633 1.3371615013742735 0.6085647605380726 0.10716977459477053 170.1447578470681 306481.85110839765 0.037048064793955726 0.0370644628243952 2.9060063167709017e-07 6.536703446013302 0.26061698414471013 NITSFCPDT(ph)PSEKTAK ddPTM_A459_Selumetinib_30min_R1 2 NITSFCPDTPSEKTAK 16 1 A9QM74 A9QM74 KPNA7 Importin subunit alpha-8 1 NIT(0.001)S(0.001)FCPDT(0.896)PS(0.103)EKTAK;NITSFCPDT(0.89)PS(0.11)EKTAK 107.99 0.00446 76309000.0 8397.5 7630.8 11891.5 11829.0 10847.900000000001 9090.1 9066.5 9024.4 5761.8 6910.6 True False 8593.145411309424 6737.382388537321 10276.699615333879 9763.287207830648 9866.709360352297 8998.661847150432 8382.606605518971 8785.04359661755 9777.353774778103 7797.642824944316 1.1020183412120814 0.8640280838440986 1.3179238708471193 1.2520818697412406 1.2653451282468502 1.1540233438705487 1.0750180270765137 1.126628109781405 1.2538858209176726 1.0 12.92882235751984 -5.2592220670659104 24.9988966589646 1.1859933918136603 0.983023218825997 0.35626186586008146 0.10604457708312838 198.23702083442646 2234964.957794123 0.027235669702385053 0.06525942389512324 5.505261248276704e-06 5.2592220670659104 -0.2029701729876633 NITSSS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 NITSSSPER 9 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 NIT(0.076)S(0.03)S(0.013)S(0.881)PER;NITSS(0.001)S(0.999)PER 132.03 0.0034615 53978300.0 9368.6 10722.8 10641.8 10277.1 9796.1 9490.3 9817.6 8489.400000000001 5311.8 7913.2 True False 9586.870151877756 9467.369591105524 9196.702011223146 8482.39741005972 8910.044484641923 9394.836198502962 9077.050527804897 8264.233534542462 9013.736641477717 8928.93630109533 1.0736855800731513 1.0603020641937095 1.0299885340312003 0.9499896879115566 0.9978842030207911 1.0521786561911612 1.0165881155061436 0.9255563323403565 1.0094972500108423 1.0 13.124272602837395 -5.4590166170573395 3.688668702315836 0.9933470374953083 1.0658331906728198 0.44114629032390185 0.03323311457438814 0.22841562740726054 6.058336775668319 0.009594989938580102 0.020923361320362665 3.475228642034717e-06 5.4590166170573395 0.0724861531775115 NITSSS(ph)PER ddPTM_A459_Selumetinib_30min_R2 4 NITSSSPER 9 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 NIT(0.009)S(0.004)S(0.012)S(0.976)PER;NIT(0.003)S(0.001)S(0.004)S(0.991)PER;NIT(0.024)S(0.009)S(0.003)S(0.964)PER;NIT(0.003)S(0.001)S(0.003)S(0.993)PER 126.66 0.0047511 149110000.0 915360.0 882850.0 936630.0 1024100.0 1007560.0 704630.0 748980.0 730508.0 634256.0 869560.0 True False 864487.9556764072 950561.7561898243 876368.2455256388 884615.8133289611 880981.3050993144 801686.3865057174 783809.0540757141 732633.6573378907 761124.9225933314 844453.5434117896 1.023724706256396 1.125653108576385 1.0377933189609299 1.047560070332474 1.043256093804692 0.9493552283133506 0.9281849311792125 0.8675831406638186 0.9013224333433536 1.0 19.68765853152744 -6.814698738336651 2.006133846921855 0.9125054595372045 1.0629218911641267 0.7091791567642047 0.04047665370963612 0.1613454190512248 1.335449710208887 0.016093556776187894 0.014244650827734804 1.5321499158335692e-07 6.814698738336651 0.1504164316269222 NIVQHTTDS(ph)SLEEK ddPTM_A459_Selumetinib_30min_R2 1 NIVQHTTDSSLEEK 14 0 Q9H501 Q9H501 ESF1 ESF1 homolog 1 NIVQHTT(0.008)DS(0.963)S(0.029)LEEK 151.56 0.00011973 0.0 12704.0 9581.2 9896.8 11285.0 12104.0 9843.3 10335.0 10835.0 5664.1 9468.1 True False 11997.96253814137 10316.047231586299 9260.050662821108 9747.963532289163 10583.387308867073 11199.125226419153 10815.597978413984 10866.528056169187 6797.078268177019 9194.731351921864 1.304873636752158 1.1219520001995555 1.0071039934065709 1.060168389830298 1.1510273551010226 1.2179937398691192 1.1762821081393888 1.1818211582547093 0.7392362003873345 1.0 13.166591707813486 -8.248959789145461 24.9271058585427 0.8696180964377123 1.1466064994294203 0.5768073391431264 0.09686285436029231 462.2521983849602 923321.1001126546 0.06763862872767282 0.025180134947559687 5.636898448405557e-09 8.248959789145461 0.276988402991708 NIYAFMGT(ph)PVQK ddPTM_A459_Selumetinib_30min_R1 2 NIYAFMGTPVQK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 NIYAFMGT(1)PVQK;NIYAFMGT(1)PVQK 156.96 0.0010295 50084000.0 4920.3 8206.3 7153.9 8489.3 6763.6 6499.700000000001 8312.7 6356.1 2923.2 5855.3 True False 5034.933416762817 7245.502580994629 6182.439673559852 7006.803118897353 6151.833574210569 6434.318919255417 7685.666346406836 6187.515580477464 4960.456897919288 6606.884790451833 0.762073742233136 1.096659440991875 0.9357571487389362 1.0605305436873176 0.931124693304945 0.9738809020181788 1.163281423873781 0.9365254241181207 0.7508011801701254 1.0 12.689754472166289 -8.003462239355608 24.99669206733994 0.8648214722045279 0.9952743995544093 0.12923075496923397 0.11684829003287835 219.44188882053678 1584317.5872212949 0.06191560661019252 0.028772377581249148 9.92059592190777e-09 8.003462239355608 0.13045292734988145 NIYAFMGT(ph)PVQK ddPTM_A459_Selumetinib_30min_R2 2 NIYAFMGTPVQK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 NIYAFMGT(1)PVQK;NIYAFMGT(1)PVQK 145.86 0.0015715 27540000.0 273150.0 285140.0 285390.0 281760.0 243990.0 213320.0 229280.0 241630.0 176819.0 283240.0 True False 257969.41650608595 307009.32113039226 267028.3181091381 243383.80193688945 213337.79490172493 242702.89367384228 239941.9743097007 242333.10329600034 212187.74073564942 275062.1252541011 0.9378587337961378 1.116145382963134 0.9707927540458672 0.8848321146070278 0.7755985841549231 0.8823566437932321 0.8723192045725794 0.8810122552210128 0.77141751355128 1.0 18.069397975523643 -5.686359049530329 3.258764354238775 0.8575468129854705 1.0297791576183786 0.4531743487564317 0.07244926119204098 0.18559487680186185 3.929079308790368 0.019296725629153695 0.03524793006108141 2.0589270078048614e-06 5.686359049530329 0.17223234463290804 NIYS(ph)EELR ddPTM_A459_Selumetinib_30min_R1 2 NIYSEELR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 NIYS(1)EELR;NIYS(1)EELR 123.96 0.005656899999999999 17557900.0 4689.2 4753.3 5820.2 6079.799999999999 5667.5 4904.1 4859.4 5441.6 2601.8 4134.8 True False 4798.449236405137 4196.781426250782 5029.8488080701545 5018.077061980623 5154.875625678394 4854.7692065665315 4492.851545674614 5297.271091192109 4415.064572046525 4665.541856362654 1.0284870191146673 0.8995271193478636 1.0780845961569663 1.0755614709869545 1.1048825161965719 1.0405584937461911 0.9629860119135931 1.1354031866562149 0.9463133560843445 1.0 12.187828930174325 -5.276678096566645 24.911143051855987 1.0482414499198707 0.9640070601732235 0.19295398826696764 0.06387628665063566 978.1573628232635 1599020.2036076074 0.01591928296872179 0.033344960165025625 5.288370859028568e-06 5.276678096566645 -0.08423438974664721 NIYS(ph)EELR ddPTM_A459_Selumetinib_30min_R2 2 NIYSEELR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 NIY(0.001)S(0.999)EELR;NIY(0.001)S(0.999)EELR 94.363 0.022767 9737000.0 39688.0 37451.0 40501.0 43391.0 43163.0 30327.0 30051.0 31929.0 32494.0 35467.0 True False 37482.29984365199 40323.371276055026 37895.20975415463 37481.070946349966 37740.47805788411 34504.26896890409 31448.43104492684 32021.908103869486 38993.70795821821 34442.97555566722 1.0882422101735252 1.170728446817373 1.100230428492099 1.0882065309883735 1.0957380263760146 1.0017795620804542 0.9130579033190512 0.9297079473321123 1.1321236719282872 1.0 15.071922163224091 -6.754647930617516 3.669718362285751 0.9838600497190192 1.1126583847339435 0.47747366044217054 0.05910951230689749 0.19184090680104582 5.547054426042969 0.021405644129271068 0.02006718943724195 1.7593492871851748e-07 6.754647930617516 0.12879833501492433 NIYSEELR ddPTM_A459_Selumetinib_30min_R2 2 NIYSEELR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 138.06 0.034513 19116300.0 89067.0 75208.0 99387.0 105418.0 90905.0 72315.0 70708.0 70849.0 64320.0 86549.0 False True 84117.01270345064 80976.21176816503 92992.54862438396 91059.88654380655 79484.70119898878 82275.7348397896 73996.06210524394 71055.15886031666 77185.79725095704 84050.10548869202 1.0007960396286193 0.9634278422060928 1.106394192888848 1.0834000268572848 0.9456823490802465 0.9788891323980415 0.8803803597272019 0.8453904780628303 0.9183307599934126 1.0 16.358962009694025 -6.734551334375387 1.7821117179525916 0.9024649768458843 1.0346533058641283 0.4570326376131425 0.05717333336155725 0.30075409510434864 1.9740228430881441 0.02442235966457686 0.0227653172729954 1.8426746686946266e-07 6.734551334375387 0.13218832901824396 NKAGT(ph)PVSELTK ddPTM_A459_Selumetinib_30min_R1 1 NKAGTPVSELTK 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 NKAGT(0.996)PVS(0.003)ELTK 146.0 0.0069235 19682000.0 2168.0 2424.6 4605.5 4628.0 3170.4 2853.0 2150.3 2031.9 1583.0 2041.0 True False 2218.510181806349 2140.7267048340395 3980.098396200661 3819.806678319405 2883.637879779581 2824.3014103167393 1988.101139783538 1978.0074114586237 2686.235382254456 2302.9822310235504 0.9633205814273008 0.9295454719520797 1.7282366935292088 1.6586348895196246 1.2521320577006627 1.2263670002618696 0.8632724616811025 0.8588895671068668 1.1664160261716698 1.0 11.169287564523588 -7.086214767666475 3.676351304997086 0.96177825951096 1.3238342072832756 0.2824692798436149 0.2513322846919641 0.34248857143293 8.663758699873808 0.11139064459342365 0.08621129394737036 8.199459636977536e-08 7.086214767666475 0.36205594777231564 NKAS(ph)PQSEFMPSK ddPTM_A459_Selumetinib_30min_R2 2 NKASPQSEFMPSK 13 1 Q9NQW6;Q9NQW6-2;H7C1K5 Q9NQW6 ANLN Actin-binding protein anillin 1 NKAS(0.973)PQS(0.027)EFMPSK;NKAS(1)PQSEFMPSK 92.439 0.010147 13683200.0 114736.0 111880.0 117188.0 117451.0 116522.0 95797.0 101689.0 97743.0 75212.0 119567.0 True False 108359.43244459924 120460.83624909997 109648.25166464712 101453.97118572386 101883.4646401033 108992.16719141709 106417.73999293089 98027.41594777518 90256.50159886468 116114.79003762535 0.9332095627911561 1.0374288771487796 0.9443090895579896 0.8737385750157162 0.8774374445071933 0.938658780299217 0.9164873825155928 0.8442285079791367 0.7773040933856775 1.0 16.825192220584768 -5.576684338531575 4.376395154766868 0.8862689058919162 0.9870424322702595 0.29462867504071555 0.060003808517282396 0.23159998463507536 9.245475544135294 0.016482952923205747 0.03046115258556691 2.6504258673002007e-06 5.576684338531575 0.10077352637834325 NKDQGTYEDYVEGLR ddPTM_A459_Selumetinib_30min_R2 4 NKDQGTYEDYVEGLR 15 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;G3V1Y7;F8VPF3;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 0 ;;; 166.86 0.00021614 45333400.0 136365.0 143136.0 144128.0 173037.0 152098.0 110317.0 114157.0 116110.0 81405.0 147841.0 False True 128786.3792123465 154114.07094521934 134854.96139470098 149469.06209452523 132990.089466628 125512.16539198042 119465.52669780409 116447.86087695461 97688.27464574248 143572.44619295152 0.897013198753098 1.073423731584963 0.9392816307765988 1.0410706654231485 0.9262925651339704 0.8742078909995075 0.8320922981088629 0.8110738791791335 0.6804110206108499 1.0 17.131419374328736 -6.797461035991118 1.7533246137840452 0.8145499074015758 0.9907284391671003 0.39517485092908544 0.08627387094083604 0.31683912360159405 2.012609916990956 0.03490000174666775 0.03100634950605347 1.594185901381e-07 6.797461035991118 0.17617853176552445 NKDQSEQETSDADQHVTS(ph)NASDSESSYR ddPTM_A459_Selumetinib_30min_R2 1 NKDQSEQETSDADQHVTSNASDSESSYR 28 1 A0A590UJ08;A0A0C4DFT3;A0A590UJD9;Q12959-4;Q12959-2 A0A590UJ08 DLG1 Disks large homolog 1 1 NKDQSEQETSDADQHVT(0.137)S(0.481)NAS(0.33)DS(0.03)ES(0.008)S(0.009)Y(0.005)R 51.858 0.010698 5243300.0 9648.7 11204.0 14853.0 15127.0 15912.0 11941.0 12821.0 13687.0 11093.0 14402.0 True False 9112.463880806412 12063.31077346187 13897.374150723652 13066.676504469497 13912.992304915137 13585.764360394502 13417.201904329542 13726.826903995165 13311.909964316954 13986.176839110149 0.6515335810230024 0.8625166771614609 0.9936506817118046 0.934256491590367 0.9947673667338194 0.9713708411296533 0.9593187658553296 0.9814566955574484 0.951790479803765 1.0 13.77171403118381 -4.800617919662224 2.2001838775469276 0.9717963697277785 0.5745978263884165 0.9569891429184219 0.02083791377612645 0.10203865227955598 0.5965432565649709 0.005119058940617283 0.07956005993109734 1.5826397899175404e-05 4.800617919662224 -0.397198543339362 NKDQSEQETSDADQHVTSNAS(ph)DSESSYR ddPTM_A459_Selumetinib_30min_R1 2 NKDQSEQETSDADQHVTSNASDSESSYR 28 1 A0A590UJ08;A0A0C4DFT3;A0A590UJD9;Q12959-4;Q12959-2 A0A590UJ08 DLG1 Disks large homolog 1 1 NKDQSEQETSDADQHVT(0.003)S(0.008)NAS(0.943)DS(0.041)ES(0.005)S(0.001)YR;NKDQSEQETSDADQHVT(0.019)S(0.207)NAS(0.605)DS(0.149)ES(0.015)S(0.006)YR 166.77 5.638200000000001e-22 17759100.0 1270.96 1300.0900000000001 1190.38 1156.81 1344.79 1457.17 1458.98 1198.27 369.58 1197.26 True False 1300.5708951423433 1147.8748584045563 1028.7329342892933 954.7948495131097 1223.1539819419577 1442.5121928045007 1348.9279639684635 1166.4879870704874 627.1502669447899 1350.939983299978 0.9627155249083703 0.8496860501534725 0.7614941796129088 0.706763336133413 0.905409564497548 1.067784069341731 0.9985106523188397 0.8634639595321439 0.4642325156539026 1.0 10.399747867749971 -11.901843207804822 2.287046702592809 2.105496362552526 0.8498026996985623 0.07693772722176495 0.16204352752711232 8118074.426947651 1527280.0343296449 46159034.34096009 0.04218498804870348 1.2535936748832092e-12 11.901843207804822 -1.2556936628539637 NKDQSEQETSDADQHVTSNAS(ph)DSESSYR ddPTM_A459_Selumetinib_30min_R2 3 NKDQSEQETSDADQHVTSNASDSESSYR 28 1 A0A590UJ08;A0A0C4DFT3;A0A590UJD9;Q12959-4;Q12959-2 A0A590UJ08 DLG1 Disks large homolog 1 1 NKDQSEQETSDADQHVT(0.008)S(0.068)NAS(0.806)DS(0.086)ES(0.014)S(0.018)YR;NKDQSEQETSDADQHVT(0.102)S(0.362)NAS(0.486)DS(0.041)ES(0.007)S(0.003)YR;NKDQSEQETSDADQHVT(0.028)S(0.217)NAS(0.497)DS(0.158)ES(0.069)S(0.031)YR 82.581 2.6932e-05 32141200.0 121991.2 97682.0 122861.8 139971.0 139386.0 99997.9 138203.4 126014.1 103760.8 127811.0 True False 115211.41747346589 105173.8953028652 114957.00554981326 120906.70833655719 121875.08455334965 113771.70303444384 144630.13194484162 126380.78016824277 124515.85931898479 124120.76433714086 0.9282203351610443 0.84735133452118 0.9261706223268437 0.9741054124364433 0.9819072997513016 0.9166210314771623 1.1652372003768245 1.0182082010465483 1.003183149765101 1.0 16.92138496057663 -6.210469327198636 0.8599455236005916 1.0375939858161038 0.8848045865365108 0.4409036900027017 0.059718927326772094 0.586885087553783 0.9225398767341877 0.030856774168093556 0.05453086251590356 6.159290286356029e-07 6.210469327198636 -0.152789399279593 NKDSGSDTASAIIPS(ph)TTPSVDSDDESVVK ddPTM_A459_Selumetinib_30min_R2 1 NKDSGSDTASAIIPSTTPSVDSDDESVVK 29 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 NKDSGSDTASAIIPS(0.221)T(0.221)T(0.087)PS(0.184)VDS(0.147)DDES(0.14)VVK 48.025 0.019198 5299500.0 27238.0 21928.0 22196.0 28076.0 20155.0 17441.0 20122.0 20489.0 14438.0 19756.0 True False 25724.22100235317 23609.807090367 20767.93352517755 24252.000366198543 17622.948712013855 19843.339436365484 21057.71287098657 20548.61959786346 17326.003431425954 19185.59294774754 1.3408092766490851 1.2306008552703542 1.082475458628751 1.264073538527034 0.9185511628444538 1.0342833547240022 1.0975794664432732 1.0710442806656097 0.9030736489934803 1.0 14.227735732947577 -1.5228787452806052 0.34687345132212355 0.9914983162835714 5.0977570015717415 0.6194353977982813 0.0847667151088206 41.42207136938003 0.5844154789962466 0.07233419888534122 110.90498990059804 0.029999999999981514 1.5228787452806052 4.10625868528817 NKDSGSDTASAIIPSTTPSVDS(ph)DDESVVK ddPTM_A459_Selumetinib_30min_R1 4 NKDSGSDTASAIIPSTTPSVDSDDESVVK 29 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 NKDSGSDTASAIIPS(0.007)T(0.007)T(0.002)PS(0.036)VDS(0.945)DDES(0.003)VVK;NKDSGSDTASAIIPS(0.052)T(0.139)T(0.052)PS(0.036)VDS(0.703)DDES(0.018)VVK;NKDSGSDTASAIIPS(0.004)T(0.004)T(0.003)PS(0.147)VDS(0.753)DDES(0.09)VVK;NKDSGSDTASAIIPS(0.229)T(0.229)T(0.018)PS(0.137)VDS(0.387)DDESVVK 150.31 5.8464e-16 14991500.0 21892.18 17015.12 29365.1 25683.1 21821.4 22572.6 20674.47 22842.92 14834.49 18227.550000000003 True False 22402.22519923309 15022.981840285318 25377.480710948214 21198.028716496363 19847.65822288107 22345.54013828097 19114.978082788715 22237.05155733866 25173.046061718203 20567.233593872283 1.0892191746150788 0.730432791153848 1.2338791503058086 1.030669906078765 0.9650135071541366 1.0864630887908282 0.9293898469886467 1.0811882626725198 1.223939327903494 1.0 14.328060136037447 -7.991168856733853 23.992717156214834 1.1255010489083883 1.0090085101729886 0.09430396607321023 0.1322076829836823 231.94466206604596 630154.2046975193 0.06946377310700341 0.03327834116689193 1.020542612449815e-08 7.991168856733853 -0.11649253873539966 NKDSGSDTASAIIPSTTPSVDS(ph)DDESVVK ddPTM_A459_Selumetinib_30min_R2 1 NKDSGSDTASAIIPSTTPSVDSDDESVVK 29 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 NKDSGSDTASAIIPS(0.001)T(0.001)TPS(0.019)VDS(0.94)DDES(0.039)VVK 97.957 9.5802e-05 0.0 18667.0 17804.0 16180.0 20827.0 15847.0 10483.0 13695.0 13126.0 8454.8 15280.0 True False 17629.562869921687 19169.50955111703 15138.996415452 17990.32667142104 13856.158186022503 11926.938094800731 14331.844636127671 13164.194486873714 10145.996246849993 14838.826697792185 1.1880698675822345 1.2918480646430888 1.020228669272381 1.212382018997348 0.9337772094935316 0.8037655764640271 0.965834087021183 0.8871452409935057 0.6837465288518787 1.0 13.857089402492244 -6.358345120227826 4.02263019587536 0.8672391406195712 1.1754313130355007 0.6725834583816293 0.10281468807015155 0.14022968861601295 4.064466203963536 0.032413833541254974 0.037260320261395155 4.381823495880653e-07 6.358345120227826 0.30819217241592956 NKELYEINPPEIS(ph)EEIIGSPIPEPR ddPTM_A459_Selumetinib_30min_R1 2 NKELYEINPPEISEEIIGSPIPEPR 25 1 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 NKELYEINPPEIS(0.985)EEIIGS(0.015)PIPEPR;NKELYEINPPEIS(0.994)EEIIGS(0.006)PIPEPR 152.2 1.8558e-10 11320700.0 2527.9 2280.0 3550.0 3539.7 3246.7000000000003 2773.2 2567.27 2583.81 1675.34 2095.38 True False 2586.7951515628574 2013.0565400567577 3067.9294987541734 2921.55784339827 2953.0365582514423 2745.304125864135 2373.618756979065 2515.278965402286 2842.9296180076944 2364.3424337296083 1.0940865056853644 0.8514234280697157 1.2975825561421315 1.235674579840657 1.2489885204966713 1.1611279680556181 1.0039234262842476 1.0638386933802073 1.20241872642921 1.0 11.20722328450333 -7.2265063693488365 24.160340935942433 1.0728650560037263 1.1500145483088113 0.0889901742338074 0.12579579332983074 1229.235276037114 850163.0008056457 0.05183414807091108 0.040148215943822806 5.935996424143589e-08 7.2265063693488365 0.07714949230508505 NKELYEINPPEIS(ph)EEIIGSPIPEPR ddPTM_A459_Selumetinib_30min_R2 1 NKELYEINPPEISEEIIGSPIPEPR 25 1 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 NKELYEINPPEIS(0.98)EEIIGS(0.02)PIPEPR 94.275 5.2947e-06 4099200.0 24240.0 24814.0 27595.0 31203.0 26781.0 17501.0 14806.0 19774.0 10679.0 25497.0 True False 22892.83784040829 26717.154010414415 25819.567743164283 26953.09757182267 23416.53135482228 19911.60389173973 15494.508337532421 19831.539066238078 12815.09839619045 24760.83536083816 0.9245583804743397 1.0790085884045082 1.0427583466751942 1.088537489912469 0.9457084550490557 0.8041571942775407 0.6257667849946048 0.8009236674463627 0.5175551716828933 1.0 14.595772367389543 -6.746792236400676 2.520272355375918 0.7189902017658195 1.0362493984322114 0.5438282228043427 0.12420981847342785 0.19244973303924132 2.50607399320681 0.043714230493131355 0.04083138408836618 1.7914626729300823e-07 6.746792236400676 0.3172591966663919 NKELYEINPPEISEEIIGS(ph)PIPEPR ddPTM_A459_Selumetinib_30min_R2 1 NKELYEINPPEISEEIIGSPIPEPR 25 1 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 NKELYEINPPEIS(0.178)EEIIGS(0.822)PIPEPR 48.68600000000001 0.025205 4000800.0 5081.9 5588.8 5085.7 7876.8 7614.0 4377.6 4054.6 4521.6 3159.1 6523.2 True False 4799.468342457546 6017.442989175627 4758.491598891486 6803.966251762098 6657.46124997636 4980.574664103756 4243.1469340374815 4534.757107408823 3791.0082726290157 6334.858266690966 0.7576283699500295 0.949893862790218 0.7511599152757525 1.0740518517261433 1.0509250514698423 0.7862172213531425 0.6698092925532655 0.7158419204503478 0.5984361627413743 1.0 12.629096626170318 -6.979176421820206 15.395742204404405 0.7231507239213053 0.9181698442825854 0.254220913637483 0.1384533911916097 3.793496830128435 2802.668840085781 0.04813210118584002 0.04238285653305137 1.0491161635497662e-07 6.979176421820206 0.1950191203612801 NKFGS(ph)ADNIPNLK ddPTM_A459_Selumetinib_30min_R2 1 NKFGSADNIPNLK 13 1 Q6N039;E9PC87;O94876-2;O94876 Q6N039 DKFZp686H13261;TMCC1 Transmembrane and coiled-coil domains protein 1 1 NKFGS(1)ADNIPNLK 71.402 0.031883 4226600.0 53031.0 17646.0 29554.0 34840.0 22314.0 22266.0 53729.0 37569.0 31011.0 22702.0 True False 50083.74931991302 18999.391459167113 27652.527815962218 30094.731897647715 19510.71583030898 25332.939389376428 56227.504961993756 37678.31957011722 37214.06651973614 22046.534273120305 2.271728912102815 0.8617858582122657 1.2542800366439855 1.365055002515292 0.8849788174686911 1.1490667456182895 2.55040108642145 1.7090359465730443 1.6879780766770436 1.0 14.428264260730788 NKHEAMITDLEER ddPTM_A459_Selumetinib_30min_R2 2 NKHEAMITDLEER 13 1 P35579 P35579 MYH9 Myosin-9 0 ; 86.262 0.021268 16249600.0 114688.0 108537.0 115871.0 126272.0 124887.0 97236.0 97037.0 92531.0 83801.0 113133.0 False True 108314.10009244012 116861.43889853904 108415.98601080615 109073.53576865034 109197.57855605427 110629.3763794758 101549.41277516777 92800.24989066842 100563.54159557621 109866.5563351649 0.9858696195228985 1.0636670775593908 0.9867969801480483 0.9927819657503842 0.9939109971093495 1.006943150579725 0.9242977677881848 0.8446633169020691 0.9153244167296151 1.0 16.745392767437117 -7.310613018056769 4.415347151223108 0.9059865945648078 1.0060663037360538 0.48532892793954163 0.04147953878956652 0.16001440590926397 6.8456269360103175 0.01725782437954353 0.01161976233582652 4.890879714031963e-08 7.310613018056769 0.10007970917124598 NKPGPNIES(ph)GNEDDDASFK ddPTM_A459_Selumetinib_30min_R1 6 NKPGPNIESGNEDDDASFK 19 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 NKPGPNIES(1)GNEDDDASFK;NKPGPNIES(1)GNEDDDASFK;NKPGPNIES(1)GNEDDDASFK;NKPGPNIES(0.996)GNEDDDAS(0.004)FK;NKPGPNIES(0.982)GNEDDDAS(0.018)FK;NKPGPNIES(0.997)GNEDDDAS(0.003)FK 154.1 4.8174e-06 4470150000.0 34893.0 46591.3 49671.2 52658.7 35727.2 41580.2 38069.3 37478.4 23055.2 35765.9 True False 35705.93901004105 41136.36893629228 42926.123864371344 43462.84657122259 32495.68106814945 41161.94093980095 35197.70205123071 36484.35108499971 39122.9905148155 40356.80165436808 0.8847564114679134 1.0193168747266133 1.0636651593951367 1.076964595545899 0.8052095244428824 1.019950522648658 0.8721628228291732 0.9040446613551392 0.9694274300991582 1.0 15.300524222471903 -6.234364250468906 24.9999926115477 0.9254271085687501 1.015506502378832 0.22108336665925343 0.07575279286724691 1077.6303079322279 995036.5565842172 0.021912370891243853 0.028280432538199316 5.829559636920227e-07 6.234364250468906 0.09007939381008201 NKPGPNIES(ph)GNEDDDASFK ddPTM_A459_Selumetinib_30min_R2 8 NKPGPNIESGNEDDDASFK 19 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 NKPGPNIES(1)GNEDDDASFK;NKPGPNIES(0.999)GNEDDDAS(0.001)FK;NKPGPNIES(0.972)GNEDDDAS(0.028)FK;NKPGPNIES(0.999)GNEDDDAS(0.001)FK;NKPGPNIES(0.999)GNEDDDAS(0.001)FK;NKPGPNIES(0.997)GNEDDDAS(0.003)FK;NKPGPNIES(1)GNEDDDASFK;NKPGPNIES(1)GNEDDDASFK 114.15 0.00027544 6756569000.0 630438.4 563708.0 546769.2 582699.0 501401.0 440078.6 509694.9 509777.3 341548.5 510172.2 True False 595401.157572873 606942.5909930974 511590.66494929296 503334.3909881588 438410.5237981876 500695.43251422077 533396.7227912844 511260.6675448255 409867.74366244447 495442.20299943525 1.2017570444509584 1.2250522610278909 1.032594037916217 1.015929583594098 0.8848873211527508 1.0106031127000934 1.0766073611857656 1.0319279715164038 0.8272766049825426 1.0 18.91835724060831 -5.360193563218197 2.8307475688801227 0.9819874350060955 1.2193571791345994 0.6402090944322469 0.0692669746689475 0.17326715529306225 2.64727858752213 0.019538734854261663 0.05132140152508417 4.363213223248402e-06 5.360193563218197 0.23736974412850387 NKPLEQS(ph)VEDLSK ddPTM_A459_Selumetinib_30min_R1 5 NKPLEQSVEDLSK 13 1 O95466;O95466-2;O95466-3 O95466 FMNL1 Formin-like protein 1 1 NKPLEQS(1)VEDLSK;NKPLEQS(0.993)VEDLS(0.007)K;NKPLEQS(1)VEDLSK;NKPLEQS(0.988)VEDLS(0.012)K;NKPLEQS(0.992)VEDLS(0.008)K 218.2 7.9576e-08 76074800.0 13312.9 15063.9 15309.499999999998 15472.599999999999 12222.0 14360.4 14296.5 13962.0 8592.57 15146.7 True False 13623.064667605977 13300.211584982879 13230.553989063952 12770.600866673467 11116.522257969362 14215.947414199967 13218.103494821817 13591.682405032385 14580.963713517485 17090.926486352004 0.7970933979784364 0.7782030772646404 0.7741273710134579 0.7472152476269475 0.6504341509424012 0.8317833106094127 0.7733988853896927 0.7952572036329366 0.8531406255337384 1.0 14.060942986103337 -8.737879702208922 0.9096413964230456 1.0005727674004348 0.7590319020184441 0.7323436498549527 0.043554204929098436 0.4618785191313843 0.7662174789029262 0.04336609718593078 0.014632778839905885 1.8286066625467898e-09 8.737879702208922 -0.2415408653819907 NKPLEQS(ph)VEDLSKGPPSSVPK ddPTM_A459_Selumetinib_30min_R1 1 NKPLEQSVEDLSKGPPSSVPK 21 2 O95466;O95466-2;O95466-3 O95466 FMNL1 Formin-like protein 1 1 NKPLEQS(0.806)VEDLS(0.046)KGPPS(0.119)S(0.029)VPK 108.77 0.00013756 17253000.0 1310.1 978.47 3204.0 2986.8 1955.2 1665.0 1498.1 1454.9 1110.4 1246.8 True False 1340.6227809891593 863.9102775216379 2768.9143983122185 2465.2114491798625 1778.3525052185962 1648.2516116990437 1385.0971108727708 1416.3113258187666 1884.2676995927668 1406.8389248604433 0.952932675730555 0.6140790265718137 1.968181537617671 1.7523054029972966 1.2640768419135167 1.1715993796962565 0.9845456266503081 1.0067331098044952 1.339362784392452 1.0 10.458241442228875 -6.814522252849339 3.3970567643311402 1.0847346279864718 1.3354170843962703 0.07872116972741094 0.36515387744532724 0.7044115439411812 16.55752354956211 0.14818529176607156 0.13378834106233722 1.5327726664907977e-07 6.814522252849339 0.25068245640979847 NKPLEQSVEDLS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 NKPLEQSVEDLSK 13 1 O95466;O95466-2;O95466-3 O95466 FMNL1 Formin-like protein 1 1 NKPLEQS(0.259)VEDLS(0.741)K;NKPLEQS(0.027)VEDLS(0.973)K 128.45 0.0010036 101300000.0 164840.0 117850.0 150366.0 138907.0 125486.0 133914.0 170232.0 147777.0 95561.0 135089.0 True False 155678.85270680275 126888.71605252451 140691.61526612207 119987.62697205944 109721.32682092628 152359.43794974207 178148.12530830878 148207.0066042007 114675.87019742995 131188.62956662616 1.1866794646843906 0.9672234283694696 1.0724375712353156 0.9146191050888437 0.8363630840826995 1.1613768544808527 1.357954007880184 1.1297244821734456 0.8741296450481636 1.0 17.00128315796971 -6.817262507369301 24.999937656535018 1.1285773200735822 0.9936780136108917 0.11354858978073445 0.14495432004633688 168.13777377471203 75297.67476858287 0.05328147655745903 0.04698987155180064 1.523131825237761e-07 6.817262507369301 -0.13489930646269055 NKPLS(ph)PIKLTPTSVLDYFGTGSVQR ddPTM_A459_Selumetinib_30min_R1 2 NKPLSPIKLTPTSVLDYFGTGSVQR 25 2 P35251-2;P35251;A0A1W2PP02 P35251-2 RFC1 Replication factor C subunit 1 1 NKPLS(1)PIKLTPTSVLDYFGTGSVQR;NKPLS(0.996)PIKLT(0.004)PTSVLDYFGTGSVQR 70.632 0.00042795 18677900.0 1701.6599999999999 2274.5 4367.3 4736.200000000001 2538.5 2711.9 2112.55 1922.9 1377.74 1752.6399999999999 True False 1741.3053671460307 2008.200482613638 3774.2446478617203 3909.111579484957 2308.8931232085756 2684.6207482081904 1953.1986526762382 1871.8984455405218 2337.92415385171 1977.6084161592928 0.8805106981329572 1.0154692234339082 1.9084893738426079 1.9766863589086208 1.1675178484993858 1.3575087597078415 0.9876569277903556 0.9465465611113903 1.1821977165692819 1.0 10.949541072744681 -7.058616723415697 2.0909959436773806 1.023621011355089 1.4339941728721581 0.20766036507262464 0.3329359883091883 0.5580174972390248 4.845347095856713 0.16631766851101396 0.1244590550225681 8.737421292054354e-08 7.058616723415697 0.41037316151706915 NKPPPPPPASASPSAVPNGPQS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 NKPPPPPPASASPSAVPNGPQSPK 24 1 H0Y7W6 H0Y7W6 FNBP1 1 NKPPPPPPASASPS(0.03)AVPNGPQS(0.97)PK;NKPPPPPPASASPSAVPNGPQS(1)PK 135.08 4.9261e-08 37081000.0 6786.200000000001 7579.200000000001 9428.4 9961.9 6172.1 7946.6 6755.200000000001 7230.2 4603.0 7100.1 True False 6944.305256353438 6691.823740525517 8148.075066494039 8222.241173022921 5613.834644772759 7866.664418935507 6245.649825357283 7038.431609000509 7810.954810181468 8011.466995830631 0.8667957141891028 0.8352806975311899 1.017051567551174 1.0263090614118466 0.7007249293661623 0.9819255852928703 0.7795887855005427 0.8785446676199858 0.9749718515031623 1.0 12.967850726275644 -8.338400827934946 4.418135708420333 0.9957995354849891 0.8866522945012675 0.14993201521134591 0.09738866003180488 0.44538662923964323 15.425059789361738 0.09220375835766036 0.024537610781275306 4.5877439594307694e-09 8.338400827934946 -0.10914724098372164 NKPPPPPPASASPSAVPNGPQS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 NKPPPPPPASASPSAVPNGPQSPK 24 1 H0Y7W6 H0Y7W6 FNBP1 1 NKPPPPPPASASPSAVPNGPQS(1)PK;NKPPPPPPASASPSAVPNGPQS(1)PK 161.31 3.8253000000000004e-13 26429000.0 64993.0 67866.0 61275.0 57034.0 53719.0 41776.5 58618.0 49103.0 34804.0 52760.0 True False 61380.9492475931 73071.103976416 57332.63321117565 49265.87081086221 46970.33896604675 47530.833665691374 61343.85314936346 49245.88160056075 41765.772505011024 51236.68171305731 1.197988378547758 1.4261482503031482 1.118976313342416 0.9615351573071749 0.9167326492589134 0.9276719739947263 1.1972643640919158 0.961145022551505 0.8151537357339694 1.0 15.64488942370804 -5.510561904444214 3.836395827708644 0.9741043729168263 1.3104728600213895 0.6325307493212243 0.10427210594501281 0.1371194837178375 4.453388148038863 0.02916609835573993 0.05975194588266893 3.0862996923980014e-06 5.510561904444214 0.33636848710456324 NKPRPPPLSPLGGPVPSALPNGPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 NKPRPPPLSPLGGPVPSALPNGPPSPR 27 2 Q15642 Q15642 TRIP10 Cdc42-interacting protein 4 1 NKPRPPPLSPLGGPVPSALPNGPPS(1)PR 70.083 0.00026529 14831000.0 2378.8 3185.9 3347.2 3830.3 2493.8 2852.6 3016.5 2349.7 1837.3 2593.4 True False 2434.221411660953 2812.893346915273 2892.6686248535116 3161.4100086358726 2268.2362303161503 2823.9054339535664 2788.962976401917 2287.3783230987397 3117.763908917319 2926.288151855208 0.8318461085651135 0.9612496107507236 0.9885112042092019 1.0803481559502615 0.7751240180766662 0.9650127695603958 0.9530718889162607 0.7816654424987463 1.0654329810072598 1.0 11.51485612344269 NKQDDDLNCEPLS(ph)PHNITPEPVSK ddPTM_A459_Selumetinib_30min_R1 4 NKQDDDLNCEPLSPHNITPEPVSK 24 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73;F8WE35;F5H8I0;F5H2W9;F5H2H9;F5GZ10;F5H502;F5H1K9 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 NKQDDDLNCEPLS(0.997)PHNIT(0.003)PEPVSK;NKQDDDLNCEPLS(1)PHNITPEPVSK;NKQDDDLNCEPLS(0.997)PHNIT(0.003)PEPVSK;NKQDDDLNCEPLS(0.999)PHNIT(0.001)PEPVSK 109.05 2.4211e-07 78277400.0 14731.400000000001 17468.1 18448.9 20761.2 16330.2 15785.8 16620.1 15890.7 9841.3 14423.0 True False 15074.612957685453 15422.926731300618 15943.640712553777 17135.64615599068 14853.136293330977 15627.009184359607 15366.43247608073 15469.227015731842 16699.9673198868 16274.332541917036 0.9262814876652224 0.9476841333785277 0.9796801602454963 1.052924665995069 0.9126725323496033 0.9602242761176135 0.9442127618138643 0.9505291216022825 1.0261537471274769 1.0 13.990310755001037 -8.259487541280645 24.97519010290954 1.0130768764697264 0.9606675309454658 0.2584569253847294 0.03639107132145873 245.59361930972892 3142655.783002794 0.028651223973089928 0.009560795736505371 5.5018970372021086e-09 8.259487541280645 -0.052409345524260686 NKQDDDLNCEPLS(ph)PHNITPEPVSK ddPTM_A459_Selumetinib_30min_R2 2 NKQDDDLNCEPLSPHNITPEPVSK 24 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;A8MV73;F8WE35;F5H8I0;F5H2W9;F5H2H9;F5GZ10;F5H502;F5H1K9 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 NKQDDDLNCEPLS(0.998)PHNIT(0.002)PEPVSK;NKQDDDLNCEPLS(0.999)PHNIT(0.001)PEPVSK 94.207 7.9716e-06 85058000.0 190918.0 173035.0 178600.0 193489.0 185848.0 149419.0 161073.0 155305.0 110933.0 178026.0 True False 180307.541865308 186306.2281047819 167109.0704449769 167135.4644128576 162500.11273779973 170000.11095936561 168563.21366009433 155756.91183787308 133122.69972699668 172885.92681290285 1.0429278148269225 1.0776251805990116 0.9665857338742346 0.9667384008284932 0.9399267813953264 0.9833079770763512 0.9749967320504546 0.9009230231124203 0.7700031007790592 1.0 17.39946091054498 -5.283156483078127 0.4600769425863078 0.9031682955412441 1.1328715832697713 0.39733203357928915 0.061671249828074995 3.3350875342506408 0.7680251555973313 0.04809080669823434 0.3977823271523432 5.2100695034706466e-06 5.283156483078127 0.22970328772852722 NKS(ph)ESQCDEDGMTSSLSESLK ddPTM_A459_Selumetinib_30min_R2 2 NKSESQCDEDGMTSSLSESLK 21 1 A0A2R8Y6S1;A0A2R8YFV7;A0A2R8Y5N2;A0A2R8Y5S3;Q92574-2;Q92574 A0A2R8Y6S1 TSC1 Hamartin 1 NKS(0.5)ES(0.5)QCDEDGMTSSLSESLK;NKS(0.498)ES(0.498)QCDEDGMT(0.003)SSLSESLK 76.78 0.0015094000000000002 17423000.0 95714.0 74058.0 90838.0 96370.0 82163.0 82737.0 79453.0 92179.0 62982.0 85799.0 True False 90394.59905349997 79738.01046599777 84993.58197693624 83244.2397524775 71840.94939346045 94133.27073829327 83147.72193313274 92447.225628945 75580.1598641135 83321.75993742609 1.0848858584046415 0.9569890329474595 1.0200646510679283 0.9990696285699341 0.8622111372516901 1.129756150241984 0.9979112538618476 1.1095207986289783 0.9070878954173981 1.0 16.346405692117898 -6.784341925699228 24.999698010329023 1.0337661857251927 0.9858767602762021 0.07269336733500376 0.07790978653914768 635.0122650930631 693154.5819434557 0.02623578055861985 0.023152633418148202 1.643077597458765e-07 6.784341925699228 -0.04788942544899066 NKS(ph)NEDQSMGNWQIK ddPTM_A459_Selumetinib_30min_R1 1 NKSNEDQSMGNWQIK 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 NKS(0.934)NEDQS(0.066)MGNWQIK 80.585 0.015895 59666000.0 3067.2 3493.1 3246.9 3329.0 2406.1 2875.1 2794.1 2841.0 1459.8 2393.7 True False 3138.6597922677283 3084.126228101868 2805.9888139450504 2747.6526430694257 2188.468679831457 2846.1791043819344 2583.338787457184 2765.6474511314277 2477.173980426442 2700.9547116124822 1.1620556904465584 1.141865213378802 1.0388877687881934 1.0172894166852078 0.8102574509755224 1.0537678000097797 0.9564539443591481 1.023951804612201 0.9171475440799072 1.0 11.399253734253561 -5.440935939710356 1.879460102956408 0.964816896767642 1.1630236155803195 0.570244350817886 0.06387772569770883 0.26393913348092235 1.7636262507173421 0.018389699313890166 0.0563307007991101 3.6229643474595974e-06 5.440935939710356 0.19820671881267748 NKS(ph)NEDQSMGNWQIK ddPTM_A459_Selumetinib_30min_R2 2 NKSNEDQSMGNWQIK 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 NKS(0.998)NEDQS(0.002)MGNWQIK;NKS(0.694)NEDQS(0.306)MGNWQIK 113.81 0.0063023 63744000.0 80969.0 68691.0 83476.0 72864.0 67257.0 61083.0 68329.0 62435.0 49532.0 61600.0 True False 76469.06712458817 73959.37882362277 78105.24504179679 62939.79750258901 58807.57437479124 69496.62879373397 71506.43389134493 62616.6755133293 59439.784039713995 59821.44794397893 1.27828846931621 1.2363354844383507 1.3056394942987692 1.0521276175315972 0.9830516711976421 1.161734314067683 1.1953310451179426 1.046726177072277 0.9936199487410878 1.0 15.868375210038758 -1.5228787452803398 0.23537232810392122 1.0084688217534628 2.758984440858462 0.5362796606494333 0.08036914677542065 44.58105333721073 0.5902068999366942 0.12513205805127564 30.290317715805234 0.029999999999999843 1.5228787452803398 1.7505156191049993 NKS(ph)PAAVTEPETNK ddPTM_A459_Selumetinib_30min_R2 2 NKSPAAVTEPETNK 14 1 B7ZBC9;B7ZBC8;O75449 B7ZBC9 KATNA1 Katanin p60 ATPase-containing subunit A1 1 NKS(1)PAAVTEPETNK;NKS(1)PAAVTEPETNK 102.47 0.004162399999999999 21232200.0 143706.0 91842.0 117401.0 129735.0 118159.0 103246.0 145207.0 163744.0 108572.0 101762.0 True False 135719.39582069792 98885.98608142484 109847.54747654415 112064.86919464217 103314.81006513751 117467.19932612771 151959.41322221197 164220.46793072144 130289.43375514491 98823.8666505711 1.3733463425448107 1.0006285873338006 1.1115487705510594 1.1339858780358152 1.0454439151874702 1.1886521273396145 1.5376792911728656 1.6617490642355108 1.3184004853385483 1.0 16.59257188431757 -7.129669539336387 5.201223880941399 1.432862773674903 1.1240763145050714 0.26414213694209254 0.18665408680647658 0.23936613218344496 9.12292114104691 0.06943493368537158 0.05354258682393026 7.418745291519951e-08 7.129669539336387 -0.3087864591698315 NKSNEDQS(ph)MGNWQIK ddPTM_A459_Selumetinib_30min_R2 1 NKSNEDQSMGNWQIK 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 NKS(0.224)NEDQS(0.776)MGNWQIK 102.63 0.029303 10385000.0 51515.0 45453.0 40807.0 48135.0 38156.0 32217.0 44594.0 38445.0 28045.0 37012.0 True False 48652.00253088418 48939.09894556967 38181.52204730226 41578.9299624935 33362.502161032055 36654.59931319232 46667.70936133464 38556.86858508763 33654.7836427719 35943.367391275126 1.3535738597128197 1.3615613254268748 1.0622689196497048 1.1567900555857866 0.9281963428148485 1.019787570657329 1.2983677587387856 1.0727116401021153 0.9363280651033616 1.0 15.13343795509506 -5.261249316647741 24.683297768839427 1.0678287236086228 1.357567621609243 0.5748317092144684 0.10239498739050505 10.039307512678166 1303525.4875574454 0.027528436281412355 0.06405620148971437 5.479623043580081e-06 5.261249316647741 0.28973889800062014 NKSS(ph)SPEDPGAEV ddPTM_A459_Selumetinib_30min_R1 1 NKSSSPEDPGAEV 13 1 Q9Y5U2-2;Q9Y5U2 Q9Y5U2-2 TSSC4 Protein TSSC4 1 NKS(0.173)S(0.579)S(0.247)PEDPGAEV 112.02 0.02398 8583300.0 3051.3 2509.1 13935.0 14083.0 7752.4 4810.2 4329.3 4393.9 3052.7 2305.9 True False 3122.3893532037446 2215.333405551057 12042.703539475888 11623.668420650858 7051.196788797387 4761.813755312155 4002.737415460575 4277.359498601332 5180.208939613508 2601.8847263680573 1.2000490727205482 0.85143410970532 4.628453911671239 4.467403303018813 2.7100342752847766 1.8301401699525404 1.5383992130381399 1.6439465804359643 1.990944828230152 1.0 11.34534133112169 -6.782350679007251 4.175886538572267 1.614988882569141 2.872527552741302 0.20838573509881697 1.1422739736379057 0.3860611705083292 15.159763523646784 0.45681689523530405 0.4200841022286322 1.6506284299179986e-07 6.782350679007251 1.257538670172161 NLAANDLS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 NLAANDLSPSR 11 0 Q96CB9-4;Q96CB9 Q96CB9-4 NSUN4 5-methylcytosine rRNA methyltransferase NSUN4 1 NLAANDLS(0.88)PS(0.12)R 95.428 0.021233 6979400.0 2759.0 3355.9 2730.2 3593.1 3272.0 3037.2 2849.8 2638.8 1240.9 2057.6 True False 2823.279331920536 2962.9896678844166 2359.453835915111 2965.632535840419 2976.04817771852 3006.6485255569555 2634.8372916128565 2568.8104519695917 2105.7166682498787 2321.7130027212447 1.216032872543425 1.2762084135341194 1.0162555979785748 1.2773467402579244 1.2818329286308596 1.2950130020518937 1.134867784486973 1.1064289380120316 0.9069668239708353 1.0 11.180973929931454 -7.914756287637778 1.995706791898593 0.9574177849212515 1.2219629669829672 0.6129899029595764 0.08264421636847731 0.23538091141267925 1.7598398313626917 0.06739476865324688 0.024169610333528303 1.2168686773923863e-08 7.914756287637778 0.26454518206171573 NLADEIESYMNLKS(ph)PLGSK ddPTM_A459_Selumetinib_30min_R1 2 NLADEIESYMNLKSPLGSK 19 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 NLADEIESYMNLKS(0.794)PLGS(0.206)K;NLADEIES(0.002)Y(0.009)MNLKS(0.981)PLGS(0.008)K 90.468 0.0014772 23746200.0 2704.2 3178.2 3227.5 4049.0 2980.4 2922.7 2759.9 2626.0 1652.77 2002.1599999999999 True False 2767.202598542772 2806.0948664949033 2789.2232273884765 3341.9181591433166 2710.8233462323587 2893.300291599275 2551.7185209917616 2556.3499495498513 2804.629976455274 2259.156738689914 1.2248829623691688 1.242098353973509 1.2346302403993217 1.4792768035569308 1.1999270788995218 1.2806992281894973 1.1295004358447056 1.1315505054475679 1.241449930597414 1.0 11.141568652022672 -7.260039363487811 23.938207661896875 1.1365877517764955 1.279112574199815 0.3979032618662386 0.09075023738302342 78.0480625302985 1334529.5790713842 0.035837055522260935 0.02621325259700974 5.494910669498934e-08 7.260039363487811 0.14252482242331954 NLAPHHAS(ph)PDPPAPPASASDPHR ddPTM_A459_Selumetinib_30min_R2 4 NLAPHHASPDPPAPPASASDPHR 23 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 NLAPHHAS(1)PDPPAPPASASDPHR;NLAPHHAS(1)PDPPAPPASASDPHR;NLAPHHAS(1)PDPPAPPASASDPHR;NLAPHHAS(1)PDPPAPPASASDPHR 103.31 1.5535999999999998e-05 42250000.0 62898.0 56968.0 77454.0 85011.0 90351.0 62537.0 63723.0 71717.9 58251.0 81265.0 True False 59402.3809606436 61337.26241900893 72470.69396553893 73432.35514784537 79000.29963181172 71150.90409563605 66686.2457647291 71926.58721546242 69902.82766892861 78918.66829817288 0.7527037929252397 0.7772212043323214 0.9182959561827371 0.9304814276693196 1.0010343729234055 0.9015725382847513 0.844999633201781 0.9114014309479632 0.8857578210116224 1.0 16.268078991264346 -5.235961193101379 4.359519505311691 0.9209316977644004 0.7594566278078183 0.6668542556244441 0.045086178254320326 0.12426686409085956 5.830599496206048 0.012325871160407915 0.03322207081157812 5.8081631473341706e-06 5.235961193101379 -0.16147506995658212 NLAS(ph)PEGTLATLGLK ddPTM_A459_Selumetinib_30min_R1 1 NLASPEGTLATLGLK 15 0 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 NLAS(0.955)PEGT(0.004)LAT(0.041)LGLK 133.9 0.0004979 13234000.0 4783.7 6134.3 6351.5 7277.9 5643.9 5859.9 5417.1 4822.0 2937.3 4431.6 True False 4895.150902540145 5416.093304241302 5489.001186292153 6006.951388103027 5133.410241511478 5800.954726363498 5008.48378566777 4694.104895936554 4984.383568096029 5000.439027439477 0.9789442238328329 1.0831235566559172 1.0977038528360676 1.201284798222796 1.026591907898953 1.160089083084757 1.0016088103832779 0.9387385527906769 0.9967891900580439 1.0 12.287839050530277 -7.436841133392394 6.45974548197694 0.9746639361387459 1.0929570639653905 0.43421468112381834 0.06017764786044803 0.2182896257125563 13.571854954800196 0.02541990511698392 0.01692583444630527 3.6572855207085536e-08 7.436841133392394 0.11829312782664458 NLAS(ph)PNCVKPK ddPTM_A459_Selumetinib_30min_R2 1 NLASPNCVKPK 11 1 Q8NG27-3;Q8NG27 Q8NG27-3 PJA1 E3 ubiquitin-protein ligase Praja-1 1 NLAS(1)PNCVKPK 72.321 0.033493 44599000.0 80193.0 65573.0 73572.0 83190.0 68573.0 39479.0 66946.0 80375.0 63219.0 111030.0 True False 75736.19409801408 70602.23824957291 68838.45761913687 71859.37848924547 59958.24668960187 44916.87389531983 70059.12165098242 80608.87794320245 75864.56648644657 107824.27540941523 0.7024039235175865 0.6547898233629856 0.6384319055959627 0.6664489811444696 0.5560737270149677 0.4165747808159876 0.6497527702826078 0.7475948958351513 0.7035944938965206 1.0 16.71832249547787 -8.747821633822605 1.0227700332885543 0.9968164408754037 0.6117509122691881 0.6590049676769562 0.0817164712064142 0.564548077146734 1.153199591123857 0.0860328989056844 0.02779959334218332 1.7872214418870219e-09 8.747821633822605 -0.38506552860621557 NLASPEGT(ph)LATLGLK ddPTM_A459_Selumetinib_30min_R1 1 NLASPEGTLATLGLK 15 0 Q8TDJ6-3;Q8TDJ6;Q8TDJ6-2 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 NLASPEGT(0.999)LATLGLK 145.7 0.00083666 12570000.0 5034.3 6072.7 6742.8 6696.8 5917.1 6224.9 5992.1 5442.7 2721.7 4385.7 True False 5151.589394957432 5361.705460878363 5827.1647955491935 5527.329594505056 5381.899349748856 6162.28315775698 5540.111072732617 5298.341915618801 4618.526114897004 4948.647315335611 1.0410096066035892 1.0834688995238568 1.1775267915115109 1.1169374664014018 1.0875495881613182 1.2452459763419332 1.1195202890220302 1.0706646843066596 0.9332906187483643 1.0 12.272818511238134 -8.055956500459088 3.3728204849404526 0.9683445443966537 1.1271523610111536 0.5624564125259199 0.054857544505960074 0.18648606259830544 4.069598285802052 0.04276205900368657 0.015034372012986626 8.791105653613873e-09 8.055956500459088 0.15880781661449983 NLAT(ph)MQRHRNY(ph)Y(ph)AR ddPTM_A459_Selumetinib_30min_R1 1 NLATMQRHRNYYAR 14 2 E9PPY7 E9PPY7 ARFIP2 3 NLAT(1)MQRHRNY(1)Y(1)AR 50.284 0.04428 0.0 486.51 552.24 603.58 637.51 361.84 500.37 381.34 644.47 365.9 399.98 True False 497.84473641633195 487.58348407058946 521.6171512276181 526.1808460448153 329.1116358880407 495.33673209961006 352.5752167814048 627.3765620664104 620.9055757213553 451.3213291351298 1.1030826692156457 1.0803466457145934 1.1557555948600893 1.1658674475969024 0.7292179975600082 1.097525643312332 0.7812066348759699 1.3900884393579547 1.3757505698017882 1.0 8.81801115071012 -10.65911586052463 5.217905525166737 0.9999972211442284 1.0893098038283833 0.019139552822185157 0.20192162283196882 6.756970170552137e-06 1.1189993124742076e-06 0.20238906895755465 0.0490850321341782 2.1922200196884266e-11 10.65911586052463 0.08931258268415487 NLATS(ph)ADTPPSTVPGTGK ddPTM_A459_Selumetinib_30min_R2 1 NLATSADTPPSTVPGTGK 18 0 J3KRA9;Q96Q15-4;Q96Q15-3;Q96Q15-2;Q96Q15 J3KRA9 SMG1 Serine/threonine-protein kinase SMG1 1 NLAT(0.228)S(0.772)ADTPPSTVPGTGK 124.77 0.00085821 8020700.0 22579.0 18015.0 32570.0 33474.0 40024.0 22819.0 23169.0 22043.0 22857.0 31882.0 True False 21324.149570898462 19396.6925726451 30474.481659534737 28914.783454129156 34995.827300900186 25962.11011974224 24246.404408502527 22107.141480584898 27429.038677940378 30961.483820615867 0.6887315121731881 0.6264781327996208 0.9842707098954715 0.9338952752282529 1.1303020069599516 0.8385292601013918 0.7831150648005419 0.7140207364953466 0.8859084027386507 1.0 14.918186993452542 -5.253664206699503 24.685924555905455 0.9003566690074221 0.6576047902662768 0.44452666270978247 0.11198476222851947 510.81732940007697 1621817.0377183405 0.03172724308225383 0.08060185132948901 5.576167274498425e-06 5.253664206699503 -0.24275187874114523 NLATSADT(ph)PPSTVPGTGK ddPTM_A459_Selumetinib_30min_R1 2 NLATSADTPPSTVPGTGK 18 0 J3KRA9;Q96Q15-4;Q96Q15-3;Q96Q15-2;Q96Q15 J3KRA9 SMG1 Serine/threonine-protein kinase SMG1 1 NLAT(0.001)S(0.018)ADT(0.9)PPS(0.067)T(0.012)VPGT(0.002)GK;NLAT(0.002)S(0.002)ADT(0.97)PPS(0.026)T(0.001)VPGTGK 255.22 2.7159e-33 14969400.0 6318.6 7314.3 7576.0 8272.1 6638.099999999999 5672.0 5603.3 5698.6 2703.2 4876.7 True False 6465.811086144651 6457.9383556741805 6547.220811989188 6827.533021548394 6037.685027051741 5614.944829763948 5180.638569757289 5547.454616338455 4587.132966083545 5502.671948080625 1.175031175245687 1.173600464757264 1.1898257562442751 1.2407668648918624 1.0972278711177272 1.020403339094653 0.9414769076983294 1.0081383496382064 0.8336191961586177 1.0 12.425916606971983 -6.740838239810816 1.8212901892065807 0.9460018719693626 1.193200220532093 0.837260198574054 0.04933603280743304 0.12714123259995247 0.8710742400678297 0.019522495510433554 0.01812681437925582 1.8161920076698822e-07 6.740838239810816 0.24719834856273049 NLATSADT(ph)PPSTVPGTGK ddPTM_A459_Selumetinib_30min_R2 4 NLATSADTPPSTVPGTGK 18 0 J3KRA9;Q96Q15-4;Q96Q15-3;Q96Q15-2;Q96Q15 J3KRA9 SMG1 Serine/threonine-protein kinase SMG1 1 NLAT(0.001)S(0.026)ADT(0.828)PPS(0.02)T(0.126)VPGTGK;NLAT(0.002)S(0.029)ADT(0.871)PPS(0.012)T(0.086)VPGTGK;NLAT(0.004)S(0.125)ADT(0.723)PPS(0.046)T(0.102)VPGTGK;NLAT(0.003)S(0.009)ADT(0.616)PPS(0.284)T(0.089)VPGTGK 227.57 2.5976e-18 25968600.0 202337.0 168676.0 207864.0 219065.0 234173.0 187354.0 179006.0 183999.0 135621.0 184910.0 True False 191091.91955918694 181612.90682117615 194490.25654521142 189227.96909179696 204754.09420681844 213160.31286972176 187330.1336936597 184534.40662732595 162748.98956735147 179571.1678461226 1.0641570239323532 1.0113700823998824 1.0830817601624845 1.0537770142139378 1.1402392525635043 1.1870519940728026 1.0432083053231902 1.0276393969072832 0.9063202713411859 1.0 17.45419620232996 -7.905487680718264 2.5579200436619383 0.9557731856716327 1.0868120835614974 0.5010045839099326 0.05161495735419597 0.2536788287520204 3.2252803519861355 0.03993975520400187 0.015384737342828997 1.2431178978685501e-08 7.905487680718264 0.13103889788986467 NLDDGIDDERLR ddPTM_A459_Selumetinib_30min_R1 3 NLDDGIDDERLR 12 1 P11940;E7ERJ7;P11940-2;A0A087WTT1;E7EQV3;Q9H361;H0YAR2;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 ;; 190.85 0.00039148 73226000.0 11156.7 9401.7 17305.7 16274.099999999999 14000.7 11077.5 11165.3 10535.4 6746.599999999999 9080.1 False True 11416.62940284083 8300.944593268247 14955.680993405656 13432.133937691842 12734.339157024346 10966.070407565252 10323.092431765395 10255.96696819784 11448.487447831914 10245.61928266386 1.1142937374374609 0.8101945196532817 1.4597146917913957 1.3110124012142181 1.2429057537372616 1.0703179676137717 1.0075615877346356 1.0010099619406596 1.1174031683183243 1.0 13.322719568293557 -6.900929022197479 5.427799664660124 1.0325811563643064 1.1880192363427844 0.18307501338473264 0.15817326270212873 0.40878272242035396 18.5365551795253 0.06093519412833748 0.05362006076869409 1.2562352564993112e-07 6.900929022197479 0.15543807997847803 NLDDGIDDERLR ddPTM_A459_Selumetinib_30min_R2 2 NLDDGIDDERLR 12 1 P11940;E7ERJ7;P11940-2;A0A087WTT1;E7EQV3;Q9H361;H0YAR2;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 ; 130.15 0.006221 47880000.0 665170.0 621470.0 601640.0 621230.0 552300.0 441750.0 564230.0 514490.0 313110.0 523290.0 False True 628202.5142864849 669134.7506589912 562931.1374161034 536617.4023184752 482915.13637535437 502597.05269276217 590467.8130005344 515987.0807215958 375740.74902436475 508181.25802929804 1.2361780454529618 1.3167245743258278 1.1077369118237903 1.0559566962375808 0.9502812800457765 0.9890113906242998 1.1619236319149975 1.0153603120323018 0.7393833264954889 1.0 18.95498364351799 -5.543927057369866 1.9233690026251897 0.9888844445717231 1.2820395079336095 0.5644867217377546 0.10117027736028945 0.270463093658659 1.9627470961006137 0.03099354294669885 0.08044996423820873 2.8580705349111002e-06 5.543927057369866 0.29315506336188646 NLDDTIDDEKLR ddPTM_A459_Selumetinib_30min_R2 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEU6;H0Y5F5;P0CB38 B1ANR0 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 0 112.84 0.008322 0.0 9286.4 8449.6 7566.3 9393.6 8985.8 8219.4 8850.7 8583.5 6887.6 8267.4 False True 8770.299064404604 9097.657150253792 7079.492495564561 8114.175475136158 7856.923469928764 9351.547741715645 9262.275087329332 8608.476563925085 8265.312455623309 8028.698680715127 1.0923686905165335 1.1331421830671382 0.8817733454824315 1.0106464070729602 0.9786048502232415 1.1647650651254347 1.153645871600244 1.0722131825176826 1.0294709995128508 1.0 12.970950454345028 -6.745140268893432 24.99987243915245 1.0928840468370553 1.0175093577881804 0.1417802426927962 0.07803501919338168 457.2596967254554 701351.7621669153 0.02714340741419175 0.02706289447757845 1.798290007704469e-07 6.745140268893432 -0.0753746890488749 NLDIERPTYTNLNR ddPTM_A459_Selumetinib_30min_R1 2 NLDIERPTYTNLNR 14 1 Q9BQE3;F5H5D3;F8VVB9;Q9NY65;Q9NY65-2;C9J2C0;F8VQQ4;P68363;C9JDS9;P68366-2;P68366 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA8;TUBA1A;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 118.73 0.0065262 311870000.0 6900.2 8443.5 8305.8 9285.7 8339.2 7341.299999999999 7230.8 7680.700000000001 4818.200000000001 6566.5 False True 7060.961234548054 7454.931094723343 7177.917980493642 7664.126809176859 7584.920832405343 7267.45318736708 6685.374934449523 7476.982885570278 8176.133492595348 7409.374238126482 0.9529767302364622 1.00614854306622 0.9687616996801385 1.0343824677851328 1.0236924993443508 0.9808457440266525 0.9022860392242749 1.0091247445831393 1.1034850217881216 1.0 12.855135988910725 -8.00931565698137 24.99640356575472 1.05326331536883 0.9833043908531063 0.3049529853768005 0.04221670310501513 516.8033495422519 1386714.270789917 0.025408778252691458 0.011139827536645506 9.787783242411259e-09 8.00931565698137 -0.06995892451572372 NLDIERPTYTNLNR ddPTM_A459_Selumetinib_30min_R2 3 NLDIERPTYTNLNR 14 1 Q9BQE3;F5H5D3;F8VVB9;Q9NY65;Q9NY65-2;C9J2C0;F8VQQ4;P68363;C9JDS9;P68366-2;P68366 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA8;TUBA1A;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ;; 111.72 0.010829 177970000.0 302882.0 261177.0 304685.0 367540.0 334300.0 276256.0 252755.0 269270.0 255228.0 302667.0 False True 286049.0309727119 281208.4360835815 285081.89881594514 317480.4179581361 292302.2453200811 314307.7563977169 264508.6083245308 270053.5311199521 306280.73166615824 293928.217286693 0.9731935015062 0.9567248720775084 0.9699031329744048 1.0801290903229979 0.994468132452129 1.0693350890198678 0.8999088647094173 0.9187737523565017 1.0420256159598886 1.0 18.165104339671295 -10.223412924587658 24.10312103201458 0.9999999999999938 0.9883126202370761 0.0028261497494831422 0.056686896025992695 0.0 0.0 0.0568606270588997 0.013790727723688069 5.978428993052613e-11 10.223412924587658 -0.011687379762917671 NLDSATS(ph)PQNGDQQNGYGDLFPGHK ddPTM_A459_Selumetinib_30min_R2 1 NLDSATSPQNGDQQNGYGDLFPGHK 25 0 Q92585 Q92585 MAML1 Mastermind-like protein 1 1 NLDS(0.032)AT(0.248)S(0.72)PQNGDQQNGYGDLFPGHK 87.74799999999998 4.947600000000001e-05 3866700.0 15784.0 13374.0 18945.0 14216.0 21802.0 13547.0 15606.0 17631.0 13154.0 14994.0 True False 14906.788468358269 14399.74279581214 17726.099325756386 12279.756276032149 19063.037847647054 15412.976282578033 16331.709922702352 17682.30329103083 15785.167553468418 14561.084260909429 1.023741652836727 0.9889196805535682 1.2173612217425134 0.8433270528485496 1.3091770850350433 1.0585047106660586 1.1215998499882547 1.2143534763067472 1.0840653944874938 1.0 13.829830166376993 -5.216490278455737 24.98282620330942 1.110433226492826 1.0063305800111906 0.0954032066663113 0.12222772501852551 984.6662522605865 547276.7520400088 0.0292419512943954 0.07736659416805354 6.074488602615113e-06 5.216490278455737 -0.10410264648163547 NLEELEEKST(ph)TPPPAEPVSLPQEPPKPR ddPTM_A459_Selumetinib_30min_R1 2 NLEELEEKSTTPPPAEPVSLPQEPPKPR 28 2 Q9UN86-2 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 NLEELEEKS(0.037)T(0.541)T(0.42)PPPAEPVS(0.001)LPQEPPKPR;NLEELEEKS(0.125)T(0.437)T(0.437)PPPAEPVSLPQEPPKPR 66.925 0.0010533 159863000.0 2463.58 1749.5700000000002 12472.0 12833.3 4902.6 4674.4 2924.37 2651.17 2357.12 1374.26 True False 2520.9766207077905 1544.7295310469735 10778.370903792133 10592.205065876498 4459.160695624332 4627.379780015622 2703.782416476207 2580.8523593861714 3999.8604827666613 1550.6596574259802 1.6257446362488654 0.9961757395630899 6.9508295080583355 6.830773609896478 2.875654031669543 2.984136304736816 1.7436336874619893 1.6643577119109818 2.5794573706819945 1.0 10.598666359544216 -6.867168397979383 2.2255498763525625 1.8392838484706475 4.084753779968155 0.22771066217770453 1.8368096164278465 0.5268108742590226 5.331328445420402 0.8318717856747047 0.7158885096858145 1.357786861727053e-07 6.867168397979383 2.2454699314975075 NLEELEEKSTT(ph)PPPAEPVSLPQEPPKPR ddPTM_A459_Selumetinib_30min_R1 2 NLEELEEKSTTPPPAEPVSLPQEPPKPR 28 2 Q9UN86-2 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 NLEELEEKS(0.271)T(0.271)T(0.459)PPPAEPVSLPQEPPKPR;NLEELEEKS(0.01)T(0.091)T(0.899)PPPAEPVSLPQEPPKPR 88.43299999999998 2.8708e-05 195364000.0 5368.1 4087.1000000000004 24134.9 25311.5 10675.5 10251.0 5651.7 5329.9 4287.6 3215.5099999999998 True False 5493.166285495695 3608.5804319587583 20857.51314351609 20891.321680700443 9709.902909912602 10147.884247163305 5225.387718790227 5188.53373804484 7275.744046086045 3628.252030219765 1.5139979912484114 0.9945782161500465 5.748639556952923 5.757957690561823 2.6761930618487018 2.7969072056299913 1.4401942520166449 1.4300367490542183 2.0053028250204963 1.0 11.82505895831226 -7.031096975368023 2.1561050218263755 1.4912414240198166 3.487023959865337 0.26616998668335623 1.4657071931281764 0.4968298646982722 4.607976726861606 0.7219610768302155 0.5533720599411818 9.308999878425215e-08 7.031096975368023 1.9957825358455206 NLEQILNGGES(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 NLEQILNGGESPK 13 0 Q13033-2;Q13033;G3V340;G3V3G7 Q13033-2 STRN3 Striatin-3 1 NLEQILNGGES(1)PK;NLEQILNGGES(1)PK 200.81 0.00010665 113889000.0 10268.8 13074.099999999999 10548.2 9977.6 7092.5 9088.3 9335.5 9320.599999999999 8006.5 11434.400000000001 True False 10508.043060393471 11543.378294015809 9115.812377115148 8235.19946274842 6450.984627282576 8996.879953516162 8631.31571894583 9073.387410424353 13586.445728376704 12902.116620487855 0.8144433482880843 0.8946887269400089 0.7065361944287293 0.6382828263752766 0.4999942890795736 0.6973181391981536 0.6689844754030337 0.7032479768487219 1.0530400652868206 1.0 13.655320141894846 -8.258113898388006 24.45315921778065 1.0265200682942899 0.699209741216713 0.6324791539666061 0.0986323787064985 139.91172577594526 1028836.234864961 0.08288147171862849 0.028366629673128953 5.519326700328027e-09 8.258113898388006 -0.3273103270775769 NLEQILNGGES(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 NLEQILNGGESPK 13 0 Q13033-2;Q13033;G3V340;G3V3G7 Q13033-2 STRN3 Striatin-3 1 NLEQILNGGES(1)PK;NLEQILNGGES(1)PK;NLEQILNGGES(1)PK;NLEQILNGGES(1)PK 154.47 0.00038389 20403600.0 206901.0 189518.0 167591.4 171325.0 155517.0 120308.5 184172.0 154245.5 113160.5 156016.0 True False 195402.27071032632 204053.4212035829 156808.75178371966 147990.23944789026 135979.56412038015 136879.90382317398 192736.3629298947 154694.32886828267 135795.76196854652 151511.41270175052 1.2896868112171507 1.3467858134572415 1.034963300701294 0.9767596830425462 0.8974872697415558 0.9034296584153789 1.2720913856786176 1.0210077650902623 0.8962741456041983 1.0 17.20906694422799 -5.30083061340478 5.311271265205643 1.0010513478306395 1.3195563094184406 0.600324133945286 0.10392781758783033 0.1265282388165858 9.426453087647939 0.029142466874974803 0.06513931527963204 5.002296000089538e-06 5.30083061340478 0.31850496158780106 NLEQILNGGES(ph)PKQK ddPTM_A459_Selumetinib_30min_R1 2 NLEQILNGGESPKQK 15 1 Q13033-2;Q13033;G3V340 Q13033-2 STRN3 Striatin-3 1 NLEQILNGGES(1)PKQK;NLEQILNGGES(1)PKQK 103.99 0.0029122 91573000.0 4776.4 4548.5 9672.099999999999 11005.6 5662.9 6595.3 5028.7 5134.200000000001 3932.1 4582.5 True False 4887.680826743472 4015.959505459718 8358.681945042325 9083.678560698369 5150.691694866199 6528.957270053275 4649.381110370405 4998.02433776803 6672.486510778739 5170.708512329948 0.9452632680972879 0.7766748978178439 1.6165447975089704 1.756757036107846 0.9961288056721789 1.2626813626187747 0.8991767954591913 0.9666033824668052 1.2904395006733966 1.0 12.336146262918117 -6.8871008747705496 2.1845103016280594 1.0456973960932945 1.2535530875346468 0.07172447720261677 0.2957461755505444 0.9136558151733 8.89534506848289 0.133316969481198 0.11304450764699833 1.2968780065857254e-07 6.8871008747705496 0.2078556914413523 NLEQILNGGES(ph)PKQK ddPTM_A459_Selumetinib_30min_R2 2 NLEQILNGGESPKQK 15 1 Q13033-2;Q13033;G3V340 Q13033-2 STRN3 Striatin-3 1 NLEQILNGGES(1)PKQK;NLEQILNGGES(1)PKQK 72.793 0.024736 23500000.0 129553.0 148966.0 129734.0 138422.0 103986.0 73971.0 70581.0 57711.0 48595.0 111383.0 True False 122352.96290174968 160391.21319881477 121387.05568369928 119568.6848087313 90922.3490333651 84159.83380811829 73863.15635359823 57878.9294554296 58315.357857746545 108167.08338221091 1.1311478416165908 1.4828098177711668 1.122218071229445 1.1054073112633773 0.8405731779980501 0.7780540176972097 0.682861680688949 0.5350881954625054 0.5391229571355628 1.0 16.72290200995817 -6.237603696014226 1.1179860837229738 0.6544585980012783 1.3044335867806247 0.718861419098517 0.15173079489563898 0.23744433682387375 0.6151501357300776 0.06212773066093674 0.0953184534686762 5.786238144842592e-07 6.237603696014226 0.6499749887793465 NLESHLMS(ph)PAEIPGQPVPK ddPTM_A459_Selumetinib_30min_R2 2 NLESHLMSPAEIPGQPVPK 19 0 Q9NRA8;Q9NRA8-3;Q9NRA8-2;B0QYZ7 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 NLES(0.01)HLMS(0.99)PAEIPGQPVPK;NLES(0.001)HLMS(0.999)PAEIPGQPVPK 134.34 0.00013788 5768900.0 78035.0 72488.0 77290.0 83733.0 78511.0 63314.0 67754.0 71208.0 59338.0 77679.0 True False 73698.12709885565 78047.59651434342 72317.24554698917 72328.42095251821 68647.74628275476 72034.92879273232 70904.69525200396 71415.20349088105 71207.25804224629 75436.20543571991 0.9769596266563899 1.034617211503947 0.9586543375198208 0.9588024813118433 0.9100105961884618 0.9549118805308168 0.9399292401103433 0.946696656842513 0.9439400832922706 1.0 16.20296948747189 -5.417303119205522 5.458658108361754 0.9472562927729766 1.0053811643509687 0.4325628817767089 0.0247107460743028 0.17382045771177054 7.375865982316945 0.0060982828455424555 0.012943051991161202 3.825576410388571e-06 5.417303119205522 0.058124871577992065 NLETFCEETRR ddPTM_A459_Selumetinib_30min_R2 1 NLETFCEETRR 11 1 A0A6I8PTV8;A0A6I8PIP7;A0A6I8PS05;A0A6I8PLB8;A0A6I8PRS0;A0A6I8PL42;B4DER1;A0A6I8PIT3;A0A6I8PIV1;Q9P2J5-2;Q9P2J5;A0A6I8PLB3 A0A6I8PTV8 LARS Leucine--tRNA ligase, cytoplasmic 0 122.18 0.005718899999999999 2531500.0 7068.6 7142.6 9682.3 8955.4 8860.2 5629.7 7534.1 7705.6 7196.3 9780.4 False True 6675.755509847777 7690.414452921167 9059.351359291166 7735.659071073316 7747.102464807008 6405.140073671627 7884.450578535931 7728.022020269249 8635.761081421979 9498.01443946902 0.7028580081018471 0.8096865404798326 0.9538152860291528 0.8144501274843053 0.8156549470607148 0.6743662177491596 0.8301156656250257 0.8136460593443022 0.9092175145087225 1.0 13.213410234134239 -8.47623243982546 2.013084613050604 0.9995257885062544 0.8029664962343006 0.45188845289635493 0.07099739708858774 0.3154238087077922 2.840743057181745 0.0714855550761731 0.020069297114236277 3.340162225278472e-09 8.47623243982546 -0.1965592922719538 NLETVS(ph)PERK ddPTM_A459_Selumetinib_30min_R2 2 NLETVSPERK 10 1 Q8TC05-4;Q8TC05;F5H529 Q8TC05-4 MDM1 Nuclear protein MDM1 1 NLET(0.019)VS(0.981)PERK;NLET(0.04)VS(0.96)PERK 111.94 0.015344 9111700.0 46509.0 47160.0 46763.0 51683.0 52282.0 31116.0 37085.0 38887.0 27875.0 52934.0 True False 43924.21597027842 50777.020356699606 43754.31949170472 44643.68624185208 45713.86775298975 35401.946557075236 38809.5259825334 39000.1547319106 33450.778892575036 51405.65788095101 0.8544626755288559 0.9877710440802596 0.8511576603694905 0.8684586110198453 0.889276971395975 0.6886780174871345 0.7549660403609919 0.7586743626981688 0.6507217351452402 1.0 15.649639535613971 -6.741892280416541 24.40850167544878 0.7545475719388627 0.8922649739495461 0.28094403509413324 0.09391411684724957 203.39424793382614 253977.9478693718 0.02908252637224263 0.029037756416841327 1.8117894213773106e-07 6.741892280416541 0.1377174020106834 NLFASFPTEES(ph)SINYTFKTPEK ddPTM_A459_Selumetinib_30min_R2 1 NLFASFPTEESSINYTFKTPEK 22 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NLFAS(0.001)FPT(0.087)EES(0.342)S(0.087)INY(0.079)T(0.087)FKT(0.318)PEK 45.88 0.045728 20191000.0 8143.1 9307.2 10322.0 9307.8 9168.0 6140.9 7614.5 8286.3 5762.7 8888.2 True False 7690.53910141208 10021.032312635169 9657.89375774386 8040.061583149416 8016.233877040098 6986.753233460055 7968.589337845508 8310.411761129193 6915.4010232912005 8631.57457168302 0.8909775426886622 1.160973844275231 1.1189028928079714 0.9314710214664497 0.9287104931397308 0.8094413337261764 0.9231906961665465 0.9627920945493024 0.801174914942872 1.0 13.075408044477784 -5.871642271052663 5.393761846704432 0.9013813304498959 1.066520171778334 0.38034541368987207 0.0871356921524252 0.19522908992863902 8.479965832430695 0.024149589493040257 0.03650718863695849 1.3438714540849351e-06 5.871642271052663 0.16513884132843804 NLFASFPTEESSINYT(ph)FKTPEK ddPTM_A459_Selumetinib_30min_R2 1 NLFASFPTEESSINYTFKTPEK 22 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NLFASFPTEESS(0.001)INY(0.016)T(0.526)FKT(0.457)PEK 88.573 0.00067604 18432000.0 38727.0 37925.0 37656.0 41927.0 41030.0 40636.0 39552.0 36713.0 22679.0 43044.0 True False 36574.70837646419 40833.72555190483 35233.253956752844 36216.4702718908 35875.44458714605 46233.240143119576 41391.24637080117 36819.828751835645 27215.433704204814 41801.20787825699 0.8749677397597073 0.9768551586076201 0.8428764560911054 0.8663976978217631 0.8582394243637815 1.106026416216741 0.9901925918349106 0.8808316941240251 0.6510681170617798 1.0 15.351257010247814 -11.920014331291668 2.4182671228305406 1.8958701086331433 0.9018760418976299 0.07052261508643076 0.11216702479995654 7819759.021548422 3265409.979455695 37360257.833821334 0.02929824760328717 1.2022247617256101e-12 11.920014331291668 -0.9939940667355134 NLFASFPTEESSINYTFKT(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 NLFASFPTEESSINYTFKTPEK 22 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NLFASFPT(0.001)EESS(0.001)INY(0.012)T(0.014)FKT(0.972)PEK;NLFASFPT(0.038)EES(0.205)S(0.026)INY(0.084)T(0.111)FKT(0.536)PEK 85.712 0.00085047 251330000.0 7171.9 9105.4 8399.0 8602.5 6444.5 7267.299999999999 6860.7 6309.4 4392.8 7467.1 True False 7338.991315911878 8039.335535014379 7258.461932404595 7100.234863924524 5861.596112868883 7194.197560180454 6343.191875418741 6142.05421618044 7454.260762582045 8425.575020713357 0.8710374422956022 0.9541586794077022 0.8614797108280988 0.8427003316057802 0.695690928922808 0.853852412742668 0.7528497295228748 0.7289774527057049 0.884718341983373 1.0 13.040559434009728 -5.682851268641386 2.64825670310365 0.8029158905977429 0.9111264571366525 0.12539526794091393 0.08509597075658171 0.40280732089305094 5.707055190859045 0.02327267466018336 0.04477090575506536 2.075624227741952e-06 5.682851268641386 0.10821056653890959 NLFNNQGNASPPAGPS(ph)NVPKFGSPK ddPTM_A459_Selumetinib_30min_R1 1 NLFNNQGNASPPAGPSNVPKFGSPK 25 1 D6RAE8;D6RER7;D6RFJ5;O15117;O15117-2;O15117-3 D6RAE8 FYB FYN-binding protein 1 NLFNNQGNAS(0.003)PPAGPS(0.987)NVPKFGS(0.01)PK 41.45 0.040685 13697000.0 2704.3 2826.1 3971.1 4276.4 5223.4 2832.0 4098.0 2970.5 986.44 1630.4 True False 2767.304928348206 2495.218898181754 3431.8464316909017 3529.607017969987 4750.944392266172 2803.5126512502634 3788.88456068127 2891.7126904561433 1673.916633272955 1839.6777214408621 1.5042335383508438 1.3563347911978096 1.8654606682973962 1.91860072926553 2.582487322043104 1.5239150958758754 2.0595371224660814 1.5718582971104917 0.9098966703591537 1.0 10.845237338769321 -8.140581145423969 3.5324697372857283 0.9511037440268754 1.8336502723383186 0.5265527776355972 0.3264735442442084 0.20422684590123444 4.425997923738859 0.2734866600277393 0.09048439713294634 7.234672139667055e-09 8.140581145423969 0.8825465283114432 NLFNQELLS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 1 NLFNQELLSPSKR 13 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 NLFNQELLS(0.688)PS(0.312)KR 80.488 0.018979 22148000.0 2702.8 3151.6 3832.3 4121.5 2664.4 3076.5 3076.4 2921.0 1860.1 2702.3 True False 2765.7699812667 2782.6092068609105 3311.8947093170746 3401.7573951368695 2423.4054904380255 3045.5532032385026 2844.344671176151 2843.5255912548064 3156.4538436712046 3049.1665276310364 0.9070577012451618 0.9125802679667941 1.0861639334241797 1.115635162694695 0.7947763654354496 0.9988149796477855 0.932826936607488 0.9325583124067688 1.0351857843997527 1.0 11.574199228721412 -8.269818854058382 24.19564314607823 1.017592891475326 0.962734620812744 0.06436974400862239 0.08727234301592647 1500.525404332213 4332665.936652771 0.08142417359792797 0.022510576305701014 5.372558411727529e-09 8.269818854058382 -0.05485827066258209 NLFNQELLSPS(ph)KR ddPTM_A459_Selumetinib_30min_R1 1 NLFNQELLSPSKR 13 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 NLFNQELLS(0.143)PS(0.857)KR 76.34100000000002 0.023267 20879000.0 2059.6 2239.1 2679.6 3307.3 2296.8 2718.8 2257.8 2224.7 1377.3 2221.9 True False 2107.584672716032 1976.9451310706518 2315.7250379892066 2729.742140709978 2089.0548455329754 2691.4513404728873 2087.4923282347904 2165.693729155963 2337.1775059880365 2507.1025081387693 0.8406455922221814 0.7885378139317896 0.9236658774309001 1.0888035618202514 0.8332546590142637 1.0735306321682776 0.8326314227113552 0.8638233666655049 0.9322225550813708 1.0 11.291805269649279 -5.320800734551683 6.18034780617119 0.941146503940837 0.8148579246507764 0.2653315840368482 0.0859139987509735 0.2719807863265841 21.898683285581374 0.022249789073130504 0.047605019055845785 4.777484266101272e-06 5.320800734551683 -0.12628857929006054 NLFNQELLSPS(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 NLFNQELLSPSKR 13 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 NLFNQELLS(0.072)PS(0.928)KR 61.495 0.0458 11955000.0 18454.0 21974.0 20959.0 19795.0 23499.0 18562.0 20166.0 21266.0 17294.0 19313.0 True False 17428.40055721512 23659.33514245369 19610.52075843379 17098.886851720345 20546.84553627457 21118.747010940682 21103.75895817093 21327.880539224185 20753.283234733382 18755.38350879977 0.9292478902944297 1.26146901402219 1.0455942289440685 0.9116788704266048 1.095517216517288 1.126009873433516 1.1252107400666767 1.1371604600469745 1.1065240668097363 1.0 14.19501714298001 -6.500946498791804 24.662780235706894 1.1093674533265359 1.0473893411194406 0.0812362643922312 0.09564403736534818 1773.0194403942198 1993760.5548328701 0.03003767665904395 0.0337290024273401 3.1553933157568477e-07 6.500946498791804 -0.06197811220709526 NLGS(ph)INTELQDVQR ddPTM_A459_Selumetinib_30min_R2 1 NLGSINTELQDVQR 14 0 A0A087X1A9;O75396 A0A087X1A9 SEC22B Vesicle-trafficking protein SEC22b 1 NLGS(1)INTELQDVQR 91.789 0.016531999999999998 1769400.0 10524.0 6398.3 8140.6 9358.6 6252.2 5133.0 8546.9 7270.1 6733.7 8711.8 True False 9939.11821090994 6889.029036222874 7616.842658815118 8083.942535514522 5466.742740622829 5840.024157265299 8944.347785361051 7291.2547873701515 8080.628155298025 8460.267698025256 1.1747994940195414 0.8142802665488788 0.9003075234360486 0.9555185277885978 0.6461666386630819 0.690288341423102 1.057218057940269 0.8618231771876476 0.9551267694737551 1.0 13.046487598185006 -10.376506925345858 18.354238496569227 0.9999999994831102 0.8850643800714917 0.03863659497133587 0.14974931857522267 0.0 0.0 0.14618284867923376 0.03545454857400965 4.202358264601303e-11 10.376506925345858 -0.11493561941161856 NLGSGS(ph)PKPR ddPTM_A459_Selumetinib_30min_R1 1 NLGSGSPKPR 10 1 A0A1C7CYX9 A0A1C7CYX9 1 NLGS(0.024)GS(0.976)PKPR 145.81 0.0042101000000000005 324850000.0 3006.8 3468.1 4590.7 4642.3 3775.5 3720.0 3743.2 3796.1 2459.3 3163.2 True False 3076.8525897856716 3062.0532397240513 3967.308154910082 3831.609451763652 3434.006691618665 3682.5801774897564 3460.847410332391 3695.415096529395 4173.252479834739 3569.227532177216 0.8620499987874976 0.857903625397681 1.1115313101067665 1.0735122424168864 0.9621148163462512 1.0317583130497134 0.9696348521163869 1.0353543065592137 1.1692312810579129 1.0 11.801396158332714 -5.247294440383105 24.75275500463726 1.0404209237774094 0.8599767665193703 0.6031717409332632 0.05969045829532863 483.47478476654857 846046.3605242299 0.015614477634300475 0.04085633017713332 5.658555236078038e-06 5.247294440383105 -0.18044415725803908 NLGSPT(ph)QVISKPESK ddPTM_A459_Selumetinib_30min_R1 1 NLGSPTQVISKPESK 15 1 H0YLC9;B4DFJ1;Q9BSI4-2;Q9BSI4 H0YLC9 TINF2 TERF1-interacting nuclear factor 2 1 NLGS(0.323)PT(0.675)QVIS(0.002)KPESK 137.17 0.0041738 8930600.0 978.43 978.21 1209.3 1040.1 1038.7 924.83 1007.6 961.33 586.24 863.91 True False 1001.2255153066355 863.6807184425085 1045.0837022094152 858.4660600950767 944.749768397379 915.5270498784545 931.5959207765857 935.8324055600756 994.8064627244802 974.8012636960095 1.0271073218662408 0.8860069745578891 1.0720992484631442 0.880657516630783 0.9691716697363637 0.9391935402373056 0.9556777934862245 0.9600237919386958 1.0205223359606859 1.0 9.928964311093246 -8.252935651623634 22.71244897276609 1.0102611679682054 0.9590873370440274 0.11393203299280896 0.05441592520763229 319.0163557028265 852076.1283663097 0.03500215533085005 0.012670617666072899 5.5855294806258775e-09 8.252935651623634 -0.05117383092417804 NLHYFNSDSFAS(ph)HPNYPYSDEY ddPTM_A459_Selumetinib_30min_R1 1 NLHYFNSDSFASHPNYPYSDEY 22 0 A0A0A0MSS8;P42330;S4R3Z2;P42330-2 A0A0A0MSS8;P42330-2 AKR1C3 Aldo-keto reductase family 1 member C3 1 NLHYFNS(0.1)DS(0.379)FAS(0.466)HPNY(0.008)PY(0.019)S(0.022)DEY(0.006) 51.398 0.03011 10536000.0 1174.1 2019.9 1872.7 2047.4 1851.7 1988.1 1719.0 1621.6 691.92 1428.4 True False 1201.4542455990932 1783.409168973965 1618.3976260047723 1689.860024457898 1684.2140619441866 1968.10151905037 1589.3344460251608 1578.5899003008528 1174.1377041626688 1611.7490537942379 0.745435055643889 1.1065054853146152 1.00412506661312 1.04846348163182 1.0449604781708157 1.2210967423354389 0.9860929915135916 0.9794266027857595 0.7284866719162124 1.0 10.654411421189572 -8.046020828893997 6.862362514855559 0.8593737743215448 1.0310914557096884 0.1898754388273104 0.1278986322202213 0.3491277831953769 41.73997700324626 0.08289990165645965 0.031710058573204886 8.994544423899277e-09 8.046020828893997 0.17171768138814358 NLHYFNSDSFASHPNYPYS(ph)DEY ddPTM_A459_Selumetinib_30min_R1 1 NLHYFNSDSFASHPNYPYSDEY 22 0 A0A0A0MSS8;P42330;S4R3Z2;P42330-2 A0A0A0MSS8;P42330-2 AKR1C3 Aldo-keto reductase family 1 member C3 1 NLHYFNSDSFASHPNY(0.066)PY(0.29)S(0.353)DEY(0.29) 77.031 0.0010709 9146800.0 1065.7 1635.9 1533.5 1668.1 1973.1 1431.3 2077.4 1682.7 618.85 879.77 True False 1090.5287365087759 1444.3680674907228 1325.2591229125424 1376.7976491150823 1794.6334533790973 1416.9024215164204 1920.7000454756637 1638.0693298200833 1050.143250984315 992.6970491854919 1.0985514033748311 1.454993815762651 1.3350086252396114 1.3869263036943094 1.807835990699876 1.4273261139226605 1.9348300139016212 1.6501200755700034 1.0578688149077886 1.0 9.955209693708955 -6.015014083630279 23.68387323645207 1.538226436949509 1.3202157494321 0.05166854162658985 0.290302076793195 791.6683529201176 1248817.7537998895 0.08271038702059758 0.11079525886059143 9.660195516684346e-07 6.015014083630279 -0.21801068751740882 NLHYFNSDSFASHPNYPYSDEY ddPTM_A459_Selumetinib_30min_R1 2 NLHYFNSDSFASHPNYPYSDEY 22 0 A0A0A0MSS8;P42330;S4R3Z2;P42330-2 A0A0A0MSS8;P42330-2 AKR1C3 Aldo-keto reductase family 1 member C3 0 ; 176.11 7.1832e-16 145722000.0 3382.7 3806.6000000000004 3810.4 4595.9 5732.799999999999 3997.6000000000004 4959.6 4253.4 1093.52 2247.5 False True 3461.5103284115967 3360.9215023596716 3292.9686090289856 3793.31234072778 5214.269252208047 3957.3877735303877 4585.493379003135 4140.586015009649 1855.6235724591868 2535.9885175038853 1.364955047911132 1.3252905047329429 1.298495078467539 1.4957923959614174 2.056109172505375 1.5604912034166278 1.8081680367845394 1.63273058471303 0.7317160782280017 1.0 11.308332497892678 -8.257797835856785 24.99331827068264 0.8658579948636996 1.5723480966702446 0.605101175165169 0.2267854143757816 211.72965257308394 1453208.3522617973 0.18384974417981928 0.06332858649269561 5.523344912316347e-09 8.257797835856785 0.7064901018065449 NLIEGFNS(ph)PGQETPLNTFC ddPTM_A459_Selumetinib_30min_R1 1 NLIEGFNSPGQETPLNTFC 19 0 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 NLIEGFNS(1)PGQETPLNTFC 101.05 0.0028854 0.0 143.38 223.59 257.39 252.98 269.07 166.12 302.26 341.1 119.47 0.0 True False 146.72047503108604 197.411978855829 222.43785174206673 208.80179202274053 244.73266600816683 164.44898362489192 279.46028484907794 332.0529199510488 202.7318642564371 0.0 0.0 NLLEDDS(ph)DEEEDFFLR ddPTM_A459_Selumetinib_30min_R1 4 NLLEDDSDEEEDFFLR 16 0 O75379 O75379 VAMP4 Vesicle-associated membrane protein 4 1 NLLEDDS(1)DEEEDFFLR;NLLEDDS(1)DEEEDFFLR;NLLEDDS(1)DEEEDFFLR;NLLEDDS(1)DEEEDFFLR 204.81 6.5493e-29 3516900.0 1493.0 1334.47 2047.2999999999997 1304.35 1805.04 1241.4 1640.3600000000001 1645.4 539.1600000000001 1113.8000000000002 True False 1527.7839951277126 1178.229632021728 1769.2879050139206 1076.569758181918 1641.7744507056943 1228.912643101016 1516.6263245385871 1601.7586469875578 914.9151413116325 1256.767079330736 1.2156460972396739 0.9375083509103125 1.4078089202942177 0.856618363010608 1.306347435182648 0.9778364370870113 1.2067680236708886 1.274507164717061 0.7279910146905271 1.0 10.295501579900519 -8.261076431005268 24.9991309488362 0.86399550709513 1.1414003301022853 0.2918198221480188 0.17666471795716174 37.960789276742254 2615198.7392555736 0.12560965571680116 0.04078187405190157 5.481804827546794e-09 8.261076431005268 0.2774048230071553 NLLEENFEEHS(ph)MSPER ddPTM_A459_Selumetinib_30min_R2 1 NLLEENFEEHSMSPER 16 0 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NLLEENFEEHS(0.998)MS(0.002)PER 160.95 3.3321e-05 1626500.0 7329.2 5705.8 8134.3 8616.2 7480.5 8691.2 8777.4 9412.3 7917.7 7601.9 True False 6921.872405112225 6143.416512961334 7610.947993956196 7442.658696225957 6540.7327134815 9888.333909141664 9185.566492088137 9439.688234709856 9501.461239022117 7382.413394891781 0.9376164723993614 0.8321691274038158 1.030956624458683 1.0081606512818508 0.8859884110536702 1.3394446206417865 1.2442498138134663 1.2786723974630838 1.2870399868959654 1.0 12.849876811470958 -6.757423117804846 24.999998350034144 1.248196429794314 0.9419977627080471 0.6774902424483236 0.09994536345307994 56.21850869475173 349943.24587992474 0.032336694475788054 0.031205246926511197 1.7481427048784258e-07 6.757423117804846 -0.30619866708626686 NLLEENFEEHS(ph)MSPEREMGNENIPSTVSTISR ddPTM_A459_Selumetinib_30min_R1 1 NLLEENFEEHSMSPEREMGNENIPSTVSTISR 32 1 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NLLEENFEEHS(0.498)MS(0.498)PEREMGNENIPS(0.002)T(0.001)VSTISR 50.099 0.0046926 7527100.0 506.77 583.77 666.84 870.51 990.13 678.65 538.8 549.07 278.93 462.02 True False 518.576754997234 515.4219370126897 576.286790689925 718.4917699965052 900.572916321649 671.8233971648986 498.1578822096313 534.5068799692832 473.32383775883477 521.3247674559044 0.9947287897483159 0.9886772491703762 1.1054276080191596 1.3782037893629866 1.7274700389097144 1.288684979314212 0.9555615104202149 1.025285797522547 0.9079250925841927 1.0 9.026038591885914 -7.263058780500819 24.999999937354815 0.9743002365213441 1.2567889163569161 0.30681788583761793 0.20218458993493776 216.86433992064227 3347873.8288067784 0.09458118693414203 0.06757834885469453 5.456839993433716e-08 7.263058780500819 0.282488679835572 NLLEENFEEHSMS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 NLLEENFEEHSMSPER 16 0 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NLLEENFEEHS(0.002)MS(0.998)PER;NLLEENFEEHS(0.099)MS(0.901)PER 165.19 1.2597e-05 15167100.0 4313.9 5191.5 3410.3 3591.1 4259.1 3434.6499999999996 4275.5 4524.9 2458.41 4078.5 True False 4414.405476611814 4583.676766537127 2947.199991437003 2963.98179829577 3873.8651570051798 3400.1005394126855 3952.9955927752 4404.8849530533635 4171.742214837763 4602.015202954215 0.959233136339496 0.996015129110109 0.640415092402363 0.6440617137451161 0.8417758277978727 0.7388286195208627 0.8589705636429918 0.9571643636087283 0.9065033536090357 1.0 12.168050034236785 -7.6001342732067965 3.7515644160752473 0.9485345807194808 0.7989210731172293 0.2674148298737503 0.11129754391006412 0.35659319251207977 9.896679863078166 0.0624786244455813 0.03427582921196191 2.511109937848053e-08 7.6001342732067965 -0.14961350760225156 NLLEENFEEHSMS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 NLLEENFEEHSMSPER 16 0 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NLLEENFEEHS(0.206)MS(0.794)PER;NLLEENFEEHS(0.383)MS(0.617)PER 119.38 0.0011166 4106600.0 18114.9 14639.1 18338.6 20140.4 22215.8 20889.7 18892.0 19896.2 18996.0 18210.7 True False 17108.146377690275 15761.87189787448 17158.714441557975 17397.24277587211 19424.852592228122 23767.066557183887 19770.515433787827 19954.094648006776 22795.73079258673 17684.90977391912 0.9673866927452789 0.8912610863935169 0.9702460832942923 0.9837337593618234 1.0983857334050404 1.3439178859840408 1.1179313712385721 1.1283119282538916 1.2889933329603305 1.0 14.110231238166936 -6.320224898588104 2.9857388408516905 1.182834528820347 0.9449475404443266 0.5651395366635437 0.0917188399928791 0.18316407819269237 3.2352392595912094 0.028915148141307027 0.03464942240237987 4.783822987865502e-07 6.320224898588104 -0.2378869883760204 NLLHADSNGYTNLPDVVQPSHS(ph)PTENSK ddPTM_A459_Selumetinib_30min_R2 1 NLLHADSNGYTNLPDVVQPSHSPTENSK 28 0 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 NLLHADSNGYTNLPDVVQPS(0.009)HS(0.75)PT(0.222)ENS(0.02)K 115.2 2.2196e-12 6072700.0 16749.0 17590.0 15598.0 17559.0 18389.0 12696.0 17892.0 15185.0 15176.0 17208.0 True False 15818.157631559334 18939.096439235476 14594.441661818315 15167.43390903549 16078.809420254178 14444.75875718688 18724.013452325413 15229.18583598793 18211.624052868843 16711.1603282466 0.9465624960118516 1.1333202522881092 0.8733350273200102 0.9076230262358399 0.9621599640257434 0.8643779649921223 1.120449632732954 0.9113182769389322 1.089788123334921 1.0 14.028524288992195 -7.2564871812823055 24.969738860426677 1.0229988623939206 0.9517533901111063 0.17452568638790245 0.08705867447571046 877.5388797806305 4424693.954369857 0.03386101509182363 0.025422374013787406 5.5400389578056366e-08 7.2564871812823055 -0.0712454722828143 NLLPAYRPNLS(ph)PPAEAGLALPPTGYR ddPTM_A459_Selumetinib_30min_R2 1 NLLPAYRPNLSPPAEAGLALPPTGYR 26 1 Q8N1G0;Q8N1G0-2;F8WCX2;H0Y5I5 Q8N1G0 ZNF687 Zinc finger protein 687 1 NLLPAY(0.009)RPNLS(0.938)PPAEAGLALPPT(0.049)GY(0.004)R 54.24100000000001 0.0066542 11126000.0 10069.0 8703.0 10655.0 9727.3 9658.5 8528.9 9078.7 9804.2 8475.7 11841.0 True False 9509.40528940062 9370.49211544437 9969.46890028684 8402.42495947155 8445.112881914461 9703.678557354377 9500.877539102772 9832.728598827322 10171.076830844786 11499.119563387256 0.8269681202096717 0.8148877889120875 0.8669767146372872 0.7307015909482791 0.7344138684150541 0.8438627413050394 0.826226519928812 0.8550853432409158 0.884509181314115 1.0 13.489235784183393 -8.58325164036884 0.8337638626140847 0.9992731962734367 0.8002569801079408 0.6864423775184121 0.040615303613485906 0.442965424419167 0.6776642488492809 0.042448824017452653 0.015179215697171676 2.610648245492589e-09 8.58325164036884 -0.19901621616549592 NLLQQS(ph)WEDMKR ddPTM_A459_Selumetinib_30min_R1 2 NLLQQSWEDMKR 12 1 Q8TDM6-4;Q8TDM6;Q8TDM6-2;R4GMQ2 Q8TDM6-4 DLG5 Disks large homolog 5 1 NLLQQS(1)WEDMKR;NLLQQS(1)WEDMKR 95.755 0.0091104 26664000.0 4447.7 5975.0 6435.6 7037.5 5953.7 5515.4 6453.900000000001 5717.6 3627.7 5866.200000000001 True False 4551.322756282335 5275.44422229786 5561.68086822038 5808.532735236135 5415.188886211108 5459.920083582523 5967.077126935302 5565.95067461776 6155.94194327511 6619.183911626831 0.6875957545593763 0.7969931479062479 0.8402366428361494 0.8775300418882819 0.818105216369519 0.8248630279016693 0.9014822985132531 0.840881708217983 0.9300152443962133 1.0 12.692437640784384 -1.5228787452846049 0.08440112911911425 1.1089160601600394 0.13129851703444964 0.751860325279528 0.03962982826763575 96.64713856927222 0.5934375982951376 0.9744100604158634 10.973020631669101 0.029999999999705224 1.5228787452846049 -0.9776175431255898 NLLQQS(ph)WEDMKR ddPTM_A459_Selumetinib_30min_R2 1 NLLQQSWEDMKR 12 1 Q8TDM6-4;Q8TDM6;Q8TDM6-2;R4GMQ2 Q8TDM6-4 DLG5 Disks large homolog 5 1 NLLQQS(1)WEDMKR 65.652 0.039873 7436700.0 28368.0 25272.0 24315.0 26178.0 20294.0 20070.0 20312.0 22560.0 17465.0 20528.0 True False 26791.4201261016 27210.281137712293 22750.599372170313 22612.511240431162 17744.486289338092 22834.460322679624 21256.548247464438 22625.64586499094 20958.48801287258 19935.30330185064 1.3439183603298621 1.3649293780840697 1.141221632181454 1.1342948184957884 0.890103652834358 1.145428287542525 1.066276641273431 1.1349536810353194 1.0513252643077147 1.0 14.283037934658815 -5.397752078311118 2.158254980613032 1.0617471419473061 1.367268495535398 0.7213071822218496 0.0719948350454286 0.17140822509963663 1.515173610968744 0.020290200880426906 0.05990873792107842 4.001731277147294e-06 5.397752078311118 0.30552135358809185 NLLS(ph)VAYK ddPTM_A459_Selumetinib_30min_R1 1 NLLSVAYK 8 0 P31947;P31947-2;A2IDB2;E7EX29;P63104;E7ESK7;E5RGE1;E5RIR4;E9PD24;E7EVZ2;P27348;E9PG15;P31946-2;P31946;Q4VY20;A0A0J9YWZ2;Q4VY19;A0A0J9YWE8;P61981;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4;Q04917 P31947;E7EX29;P27348;P31946-2;P61981;P62258;Q04917 SFN;YWHAH;YWHAZ;YWHAQ;YWHAB;YWHAG;YWHAE 14-3-3 protein sigma;14-3-3 protein zeta/delta;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein epsilon;14-3-3 protein eta 1 NLLS(1)VAYK 88.596 0.030848 46679000.0 4089.4 4079.3 4692.3 4263.8 2579.6 3791.6 3791.0 3919.3 2464.7 3230.1 True False 4184.675063412768 3601.6936595848806 4055.111432958932 3519.2073714386956 2346.275635465371 3753.459946497354 3505.041817848389 3815.3474323193955 4182.415885434339 3644.7147988383967 1.1481488386269516 0.9881962947369085 1.1126004795358286 0.9655645408963957 0.6437473890174206 1.0298363942478066 0.9616779395099659 1.0468164569516882 1.1475289882125514 1.0 11.831590211861895 -10.429976893906021 15.17612102425577 1.0000033934458277 0.9964938664735971 0.0 0.1376965397031084 0.0 0.0 0.1393772082778938 0.03380393832549814 3.7155499668955887e-11 10.429976893906021 -0.0035095269722306144 NLNIINTHAYNQPEDLVYS(ph)QPEMR ddPTM_A459_Selumetinib_30min_R1 1 NLNIINTHAYNQPEDLVYSQPEMR 24 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 NLNIINTHAYNQPEDLVY(0.003)S(0.997)QPEMR 96.312 1.9455e-05 10505000.0 615.79 655.46 1002.8 809.4 592.22 621.26 482.9 423.22 514.82 359.27 True False 630.1367088812418 578.7184384849129 866.6252679861088 668.0534843197335 538.6538055649331 615.0106884589472 446.47446421497943 411.9948307876953 873.6119390348961 405.3858040861495 1.5544123709554711 1.4275745047104018 2.1377790224788935 1.64794493932936 1.3287436317095664 1.5170997165165898 1.1013569289172693 1.0163030541151887 2.155013644358505 1.0 8.663151758764286 -6.213988752963692 5.1694108343035925 1.3490217225304444 1.709474384864984 0.17971841933795774 0.355085705052888 0.36422972299467016 23.089979427743256 0.1056034803119248 0.13539440623180024 6.10957846833773e-07 6.213988752963692 0.36045266233453965 NLNIINTHAYNQPEDLVYS(ph)QPEMR ddPTM_A459_Selumetinib_30min_R2 3 NLNIINTHAYNQPEDLVYSQPEMR 24 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 NLNIINTHAYNQPEDLVY(0.146)S(0.854)QPEMR;NLNIINTHAYNQPEDLVYS(1)QPEMR;NLNIINTHAYNQPEDLVYS(1)QPEMR 175.21 1.5157e-17 17273100.0 45393.9 42276.5 42768.1 42409.6 45661.7 46599.5 39154.6 33234.3 28636.6 44467.4 True False 42871.088764179454 45518.97160962703 40016.44700838649 36633.33931935939 39925.26902522269 53018.15813685647 40975.36648336799 33331.006310765464 34364.720173457004 43183.510621819645 0.9927652510613083 1.0540822400536218 0.9266603486416661 0.8483177674037783 0.9245489412583645 1.2277408060026413 0.948866034589232 0.7718456844016768 0.7957833830233638 1.0 15.398192912182987 -7.582851378373043 7.460005873008887 0.8407115869619054 0.9936395658356912 0.24059472856310193 0.11000438007878408 0.3245171182609939 33.98676825087102 0.054533929925094426 0.03133964244878313 2.6130554254083938e-08 7.582851378373043 0.15292797887378584 NLNNSNLFS(ph)PVNR ddPTM_A459_Selumetinib_30min_R1 4 NLNNSNLFSPVNR 13 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 NLNNSNLFS(1)PVNR;NLNNSNLFS(1)PVNR;NLNNSNLFS(1)PVNR;NLNNSNLFS(1)PVNR 238.88 1.0395e-17 232821000.0 6693.700000000001 7382.1 7840.599999999999 8000.199999999999 6689.200000000001 6720.0 7402.9 6980.700000000001 4317.63 6120.7 True False 6849.650186327106 6517.80030015482 6775.889585332954 6603.115252353262 6084.163041074177 6652.402901271817 6844.493292891015 6795.549159490732 7326.702762781626 6906.351465666758 0.9917899806255839 0.9437400243176843 0.9811098695190416 0.9560931390733645 0.8809518414057134 0.9632297073704714 0.9910432920937697 0.9839564628694539 1.0608644519764947 1.0 12.753708039773183 -7.690071185022298 1.6985462096434467 1.025092297702262 0.9513618589488446 0.44004060991728233 0.032593806537355836 0.35999682597830635 2.00502095778794 0.02426316159885496 0.010228998881868484 2.0414033117040648e-08 7.690071185022298 -0.07373043875341745 NLNNSNLFS(ph)PVNR ddPTM_A459_Selumetinib_30min_R2 6 NLNNSNLFSPVNR 13 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 NLNNSNLFS(1)PVNR;NLNNS(0.002)NLFS(0.998)PVNR;NLNNS(0.005)NLFS(0.995)PVNR;NLNNSNLFS(1)PVNR;NLNNSNLFS(1)PVNR;NLNNS(0.467)NLFS(0.533)PVNR 167.61 0.00030145 191089400.0 185766.0 181814.0 196169.0 198740.0 200759.0 132511.0 160287.0 161713.0 133132.0 194597.0 True False 175441.8694002179 195758.5491758477 183547.70011265817 171671.2691543778 175537.85961176836 150763.1874349078 167740.66310266516 162183.5580569716 159762.12001888093 188978.478986274 0.9283695706586816 1.0358774725351987 0.9712624479636631 0.908417032856142 0.9288775132141799 0.7977796638201227 0.8876178070776439 0.8582117864794087 0.8453984859857235 1.0 17.52786242302279 -5.979211518752602 1.7118226666375798 0.872782284557893 0.9867523153580612 0.3408191207058707 0.05622790063854134 0.3439640370477875 2.0361095375776497 0.017770303540513784 0.030140573075591672 1.0490313840445422e-06 5.979211518752602 0.11397003080016821 NLNVRS(ph)MY(ph)LMIK ddPTM_A459_Selumetinib_30min_R2 1 NLNVRSMYLMIK 12 1 Q9BUT1-3 Q9BUT1-3 BDH2 3-hydroxybutyrate dehydrogenase type 2 2 NLNVRS(1)MY(1)LMIK 67.997 0.038893 0.0 27290.0 20436.0 27694.0 28181.0 24666.0 17513.0 22285.0 23275.0 20167.0 21622.0 True False 25773.33105052567 22003.375487903155 25912.198190947332 24342.699185063437 21567.2365631622 19925.256782814562 23321.296656889754 23342.72639661632 24200.963513060466 20997.716679297282 1.227434937053747 1.0478937221587241 1.2340483771026156 1.159302202084865 1.0271229435354006 0.948924927749877 1.110658697470826 1.111679272233971 1.152552150440311 1.0 14.3579448353193 -6.245725759979827 21.709215109392108 1.0612038542731521 1.1634272066147346 0.34638384975368264 0.07300779541432574 189.12530829423588 261284.45996303938 0.022324480220760543 0.028663793125651944 5.679031008586399e-07 6.245725759979827 0.10222335234158253 NLPIMSTAS(ph)VEIDDALYSR ddPTM_A459_Selumetinib_30min_R1 1 NLPIMSTASVEIDDALYSR 19 0 A0AVT1-4;A0AVT1-3;A0AVT1 A0AVT1-4 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 NLPIMS(0.052)T(0.143)AS(0.704)VEIDDALY(0.009)S(0.092)R 58.93 0.044657 4548800.0 630.28 600.8 635.67 785.92 761.35 599.27 462.67 333.14 250.04 477.3 True False 644.9642976886096 530.4580566956573 549.3495054853704 648.6738255455464 692.4860269272602 593.2418878936247 427.7704294022459 324.3040450087731 424.2996178009506 538.5661042957084 1.197558280300688 0.9849451208767508 1.0200224282658181 1.2044460658990555 1.2857957851484831 1.1015210262246575 0.7942765539648066 0.602162004667692 0.7878320124802768 1.0 9.07297962365571 -7.264098922306802 4.72090229876188 0.7589024742429301 1.132837233284644 0.639030240073644 0.12298331125685648 0.11882119228594298 7.617488357509027 0.05248068842841969 0.03715381179559735 5.4437864176984315e-08 7.264098922306802 0.3739347590417138 NLPMHLRRAYMSIMT(ph)QMK ddPTM_A459_Selumetinib_30min_R2 1 NLPMHLRRAYMSIMTQMK 18 2 Q5JXR7;Q5JXR5;Q5JXR6;Q9P2E3-2;Q9P2E3 Q5JXR7 ZNFX1 NFX1-type zinc finger-containing protein 1 1 NLPMHLRRAY(0.045)MS(0.279)IMT(0.676)QMK 48.65600000000001 0.028256 3083100.0 8302.8 8278.2 6923.9 10608.0 6407.9 6248.8 7157.5 6100.7 5572.3 7303.9 True False 7841.363614741833 8913.111321391656 6478.42381217232 9163.172100179308 5602.882314647169 7109.5154790413835 7490.337932317184 6118.4520269747445 6686.915703070702 7093.017429188763 1.1055046308604177 1.25660361198507 0.9133523041283806 1.2918581113972127 0.789915204718167 1.0023259564800628 1.056015723504836 0.8626021419031701 0.9427462669911263 1.0 12.792183777295454 -6.262168232920651 24.99999484021286 0.9440879890881183 1.133707987531787 0.40686701776061085 0.11786581765097073 69.10102003402888 2370200.431549204 0.03439367247684277 0.041350865228052563 5.468041060200916e-07 6.262168232920651 0.18961999844366872 NLPTPT(ph)SAPTPGLAQGVHAPSTCSYMEATASSR ddPTM_A459_Selumetinib_30min_R1 1 NLPTPTSAPTPGLAQGVHAPSTCSYMEATASSR 33 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 NLPT(0.035)PT(0.52)S(0.382)APT(0.062)PGLAQGVHAPSTCSYMEATASSR 93.105 5.7854e-09 10074000.0 1017.2 1275.9 1293.3 1351.8 1196.2 920.98 1094.2 1167.8 419.77 690.16 True False 1040.898780873348 1126.5170348501817 1117.6769635883868 1115.7335064287329 1088.0039212062634 911.7157773829338 1011.6636130545265 1136.826150450997 712.3190312122255 778.7487587276895 1.3366297784845989 1.4465731370033539 1.4352215025221153 1.432725887424341 1.3971180165780699 1.170744437361909 1.2990885721697594 1.4598111877678368 0.9146968431461822 1.0 9.60501414835588 -8.265379352854906 24.99980052940022 0.9573483598993722 1.37050697350332 0.7920103957161736 0.08504133263373727 163.549931140987 1037729.9186240865 0.07833052728796147 0.023204910660458017 5.427760137362364e-09 8.265379352854906 0.4131586136039478 NLPTPT(ph)SAPTPGLAQGVHAPSTCSYMEATASSR ddPTM_A459_Selumetinib_30min_R2 1 NLPTPTSAPTPGLAQGVHAPSTCSYMEATASSR 33 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 NLPT(0.074)PT(0.743)S(0.089)APT(0.089)PGLAQGVHAPS(0.001)T(0.001)CS(0.001)Y(0.001)MEAT(0.001)AS(0.001)S(0.001)R 61.279 0.00072225 7171100.0 12941.0 14179.0 17054.0 19447.0 19055.0 12414.0 14375.0 12940.0 11960.0 14851.0 True False 12221.79102692755 15266.483707329162 15956.764206991264 16798.285052053834 16661.140546138642 14123.915816928009 15043.465983522123 12977.653257667676 14352.334190320977 14422.213042468049 0.8474282685284793 1.0585396057023322 1.1064019204268118 1.1647508605363919 1.1552416052292243 0.9793168201952318 1.043076117321573 0.8998378556365322 0.9951547760429481 1.0 13.816004938054892 -6.806728331386575 24.904672169124936 0.9809417461332085 1.0737099809115682 0.1774805519691276 0.08856893291946458 216.4853187741071 119045.04824449187 0.032964468320161325 0.02907206172836902 1.5605283706451635e-07 6.806728331386575 0.09276823477835971 NLQEAEEWYK ddPTM_A459_Selumetinib_30min_R1 3 NLQEAEEWYK 10 0 P08670;B0YJC4;H7C5W5;P41219-2;P41219;F8W835;B0YJC5 P08670;B0YJC5 VIM;PRPH Vimentin;Peripherin 0 ;; 172.27 0.0020671 28876700.0 4781.8 4446.07 4925.96 5045.4400000000005 5448.1 4919.24 4197.7 4354.620000000001 3085.14 4088.9800000000005 False True 4893.206636236901 3925.522057478135 4257.041688361439 4164.348618638694 4955.32031694018 4869.756911912554 3881.0641094123425 4239.121331800756 5235.257250289649 4613.84041303806 1.0605496068761702 0.8508144422128613 0.9226677360429808 0.9025775158739416 1.0740120752631899 1.05546713279274 0.8411786628867796 0.9187836926092195 1.1346853773909371 1.0 12.171752388531203 -8.250463206530902 24.74936851650013 1.0673426941160051 0.950829003597615 0.22060998792228714 0.08567740410353866 850.0256303968112 1916673.3773994632 0.06052081770112212 0.02237489879302235 5.617418671632354e-09 8.250463206530902 -0.11651369051839011 NLQEAEEWYK ddPTM_A459_Selumetinib_30min_R2 4 NLQEAEEWYK 10 0 P08670;B0YJC4;H7C5W5;P41219-2;P41219;F8W835;B0YJC5 P08670;B0YJC5 VIM;PRPH Vimentin;Peripherin 0 ;;; 178.08 0.0012563 34044200.0 128175.0 101895.0 116672.0 132837.0 121816.0 92642.0 94925.0 106832.0 77699.0 115569.0 False True 121051.54662517885 109710.01885593512 109165.45054286862 114744.37144339347 106512.38503114268 105402.59457965559 99339.20059031901 107142.86343301035 93240.97109145073 112232.22268567707 1.078581032509724 0.9775269190132164 0.972674762475324 1.0223834893188566 0.9490356911975838 0.9391473505327532 0.8851219214336788 0.9546533149671265 0.8307861045627319 1.0 16.776127418072832 -6.512697104952879 1.6451654132481817 0.91381665361792 1.0098408073264422 0.4221618986507517 0.0497875173589902 0.3574415316195613 1.962681675339963 0.018580132766293663 0.02053391070042426 3.0711631986570875e-07 6.512697104952879 0.09602415370852224 NLQEEIDALESR ddPTM_A459_Selumetinib_30min_R2 1 NLQEEIDALESR 12 0 Q9NQP4;E9PQY2 Q9NQP4 PFDN4 Prefoldin subunit 4 0 170.4 0.004266300000000001 1737500.0 4676.4 5779.1 6499.0 6030.0 6618.3 3495.8 5151.0 5962.0 3373.9 4699.3 False True 4416.504409112431 6222.338387264684 6080.861415576183 5208.703597669801 5786.849985647303 3977.3147182871694 5390.531706512867 5979.348432937768 4048.7742746424724 4563.618998752276 0.967763612676679 1.3634657908484282 1.3324647428364926 1.1413537368246331 1.268039682372579 0.8715264616469066 1.1811967011239708 1.3102207775391772 0.8871849897525264 1.0 12.155962635544812 NLQPLMRS(ph)PISR ddPTM_A459_Selumetinib_30min_R2 1 NLQPLMRSPISR 12 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8;Q7Z6E9-4 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 NLQPLMRS(0.999)PIS(0.001)R 98.105 0.0085734 7230900.0 31788.0 49893.0 41921.0 37759.0 46640.0 17007.0 14081.0 15723.0 15437.0 40481.0 True False 30021.350217446303 53719.63266871948 39223.84850013374 32616.15906209185 40780.666233109725 19349.559875825234 14735.794400972176 15768.75132691723 18524.831345818147 39312.208347730724 0.7636648125156589 1.366487280326505 0.9977523560412732 0.8296699786893198 1.0373537368440349 0.49220231294745304 0.3748401583199991 0.40111588714215474 0.47122337117160407 1.0 15.262689788410226 -6.762806873082592 24.90293057382218 0.49963124841930295 1.009927500687552 0.4994114598516315 0.2230880119178521 25.74537849032481 468832.6125193213 0.07396903733424692 0.06880340449301023 1.7266055275139427e-07 6.762806873082592 0.5102962522682492 NLQSPT(ph)QFQTPR ddPTM_A459_Selumetinib_30min_R2 1 NLQSPTQFQTPR 12 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 NLQS(0.417)PT(0.583)QFQTPR 163.33 0.0011689 21839000.0 67702.0 50463.0 64853.0 61706.0 83759.0 56802.0 52509.0 69336.0 44162.0 63922.0 True False 63939.39387257924 54333.34983588064 60680.42858660747 53301.536351212715 73236.44560503935 64625.95990278269 54950.772544609565 69537.75628080724 52995.63398937754 62076.405770698446 1.0300112108417232 0.8752657174866153 0.9775119521377008 0.8586440482411487 1.1797790915209319 1.0410712266670519 0.8852118910941787 1.120196239093964 0.8537162120038971 1.0 15.921757407324117 NLQYYDIS(ph)AK ddPTM_A459_Selumetinib_30min_R1 1 NLQYYDISAK 10 0 F5H018;B5MDF5;J3KQE5;P62826;B4DV51 F5H018 RAN GTP-binding nuclear protein Ran 1 NLQYYDIS(1)AK 96.82 0.020802 0.0 1523.8 2220.3 2117.3 2643.4 2154.9 2238.8 2212.4 2271.1 1205.6 1804.3 True False 1559.3015752013448 1960.3462438105337 1829.7822894963974 2181.779812763509 1959.9896754784959 2216.2797046677597 2045.516886786541 2210.86305042752 2045.81514645987 2035.8994803703044 0.7659030272544337 0.9628895054553339 0.8987586603065408 1.071653995592489 0.96271436501472 1.0885997693091638 1.0047239102465348 1.0859391987395135 1.0048704104427406 1.0 10.991450616826544 -3.818786325518174 0.7084800128572785 1.0359968558862422 2.4656240807626886e-11 0.6894569811353817 0.051637776872712766 5.223216421352486 0.7195641354248493 0.018859002724388004 5.938783023453092 0.00015177969454622237 3.818786325518174 -1.035996855861586 NLQYYDISAK ddPTM_A459_Selumetinib_30min_R2 2 NLQYYDISAK 10 0 F5H018;B5MDF5;J3KQE5;P62826;B4DV51 F5H018 RAN GTP-binding nuclear protein Ran 0 ; 180.36 0.0016852 14822500.0 83835.0 83287.0 93099.0 98802.0 101107.0 74408.0 76530.0 71118.0 58676.0 79851.0 False True 79175.78631809534 89674.84509008582 87109.11169852689 85344.99715704317 88405.03475195174 84657.02659142727 80088.7966413182 71324.94160578128 70412.83954442092 77545.49415218594 1.0210236865949927 1.1564159345492797 1.1233291199044007 1.1005797060181266 1.1400408975207965 1.0917078744160773 1.0327975534483143 0.9197818955902635 0.9080197413692803 1.0 16.24275533420665 -7.512925106127215 2.507216671814485 0.9350361074080059 1.1104884309837904 0.7543805774667098 0.04142144957763212 0.12888836251804295 1.6170386007471451 0.021661463420799994 0.011851838225097609 3.0695512853818716e-08 7.512925106127215 0.17545232357578444 NLS(ph)FEIK ddPTM_A459_Selumetinib_30min_R1 3 NLSFEIK 7 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 NLS(1)FEIK;NLS(1)FEIK;NLS(1)FEIK 99.568 0.021128 137774200.0 13089.2 13811.6 15316.0 15584.5 11295.6 12006.8 12260.400000000001 11791.4 6073.5 11195.6 True False 13394.152892850412 12194.53145116136 13236.171324765897 12862.959632296619 10273.914974400153 11886.022493302144 11335.588157095337 11478.653768134858 10306.285909110826 12632.664314378875 1.0602793329673763 0.9653174617551723 1.0477735333867846 1.0182301462452077 0.8132817209989565 0.9408959343416669 0.8973236266709654 0.9086486811075564 0.8158441998161784 1.0 13.624871324911833 -6.231506330686278 22.640135948054386 0.8937425552892333 1.0205638529483294 0.5493175697260011 0.056272995096614487 160.76436901326525 121594.91285480047 0.015603100568686053 0.020138367848267436 5.868048157355772e-07 6.231506330686278 0.1268212976590961 NLS(ph)FEIK ddPTM_A459_Selumetinib_30min_R2 6 NLSFEIK 7 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 NLS(1)FEIK;NLS(1)FEIK;NLS(1)FEIK;NLS(1)FEIK;NLS(1)FEIK;NLS(1)FEIK 96.113 0.023355 142869000.0 610615.8 464346.0 568838.4 562317.6 491808.7 369357.6 416727.4 451407.2 334741.5 449725.3 True False 576680.2183247183 499959.8450922815 532239.9566484222 485728.9728280354 430023.29428043705 420233.2567055392 436106.04982967785 452720.7202175153 401699.1534589743 436740.56206234253 1.3204182721237605 1.144752488139434 1.2186638999938997 1.1121682184369677 0.9846195467849707 0.9622034068032201 0.9985471644088462 1.036589590121221 0.9197660770552238 1.0 18.73641700136139 -6.007328461592031 2.04521404753548 0.9832126971700763 1.22629443737601 0.8361462055087211 0.04870563227491719 0.12328689486614185 1.034180720901816 0.015165063707603526 0.023854423568108844 9.832671689277225e-07 6.007328461592031 0.24308174020593376 NLS(ph)FNELYPSGTLK ddPTM_A459_Selumetinib_30min_R1 2 NLSFNELYPSGTLK 14 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 NLS(0.996)FNELY(0.002)PS(0.002)GTLK;NLS(0.74)FNELY(0.09)PS(0.169)GT(0.001)LK 193.54 0.0001161 80647000.0 10092.5 17862.3 15026.6 18115.4 12502.400000000001 14296.800000000001 13539.400000000001 10714.3 6439.0 10509.3 True False 10327.63561341356 15770.973612042013 12986.07025520549 14951.885458173581 11371.560127478004 14152.98717245579 12518.112157366524 10430.12195904874 10926.512714047036 11858.271024250756 0.8709225478396496 1.329955571076895 1.0951065487243736 1.2608824193338328 0.9589559982414464 1.1935118655588344 1.055643957855775 0.8795651522653362 0.9214254499413761 1.0 13.533606054983514 -7.589262546270333 4.692702594913179 0.9274233563442615 1.126197705793593 0.2883159561227303 0.12891306623708998 0.2370042331863112 10.230357376312543 0.05929848052288181 0.033430457825316486 2.5747641510412308e-08 7.589262546270333 0.19877434944933148 NLS(ph)FNELYPSGTLK ddPTM_A459_Selumetinib_30min_R2 1 NLSFNELYPSGTLK 14 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 NLS(1)FNELYPSGTLK 179.9 7.3142e-05 14828000.0 39246.0 44760.0 46655.0 43129.0 47415.0 39119.0 39194.0 43206.0 29389.0 41880.0 True False 37064.8644341858 48192.9480739159 43653.26809412322 37254.75579832514 41458.303804521835 44507.28716307447 41016.59866143765 43331.72230686166 35267.62119726952 40670.81558269219 0.9113381156280297 1.1849516018661996 1.0733315147164209 0.9160070990604678 1.0193624890611923 1.0943298413227525 1.0085019951970822 1.0654254576911373 0.8671481181773486 1.0 15.311706301387304 -8.24795799485835 24.9267225959026 0.9335740509474763 1.0372076310604905 0.1922597598037451 0.08227538639319207 1027.5288749624012 1899882.610673833 0.0552454189767701 0.020623387971273104 5.649916183923534e-09 8.24795799485835 0.10363358011301427 NLS(ph)GSTLYPVSNIPR ddPTM_A459_Selumetinib_30min_R2 2 NLSGSTLYPVSNIPR 15 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 NLS(0.83)GS(0.169)T(0.001)LYPVSNIPR;NLS(0.463)GS(0.269)T(0.269)LYPVSNIPR 180.02 2.0104e-05 23643700.0 37580.0 37344.0 50433.0 49120.0 44794.0 42032.0 41260.0 36712.0 33493.9 41494.0 True False 35491.4540446594 40208.16472011429 47188.195687298605 42429.771263273724 39166.57725655913 47821.526471493315 43178.67175513899 36818.82584200125 40193.61589775856 40295.96040564065 0.8807695284436323 0.9978212286134251 1.1710403527370246 1.0529534681926673 0.9719727948481052 1.1867573322510816 1.0715384698733923 0.9137100957853663 0.997460179460873 1.0 15.298347598082895 -7.746720051790563 24.951665142498765 0.9666888423406853 1.0530424975544905 0.13833264211172513 0.08735455888134568 418.6580248178306 709696.4001987458 0.0428614162046836 0.024610192206724103 1.7917604588505798e-08 7.746720051790563 0.08635365521380522 NLS(ph)NEELTK ddPTM_A459_Selumetinib_30min_R1 1 NLSNEELTK 9 0 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 NLS(0.956)NEELT(0.044)K 124.6 0.0052584 9629400.0 3631.0 4119.1 4228.0 4663.9 3789.2 3481.9 3480.2 3785.2 2252.5 2853.7 True False 3715.595235303901 3636.833857082361 3653.860822741589 3849.4374172458674 3446.4675290375967 3446.8752473122495 3217.685712074906 3684.804199937584 3822.3279839091388 3220.0001923919212 1.153911494813867 1.1294514409270275 1.1347393181450036 1.1954773873433777 1.0703314668057358 1.0704580873803606 0.999281217335799 1.1443490620416366 1.1870583091704068 1.0 11.652845059201626 -6.280651609773863 24.45626142312934 1.0814261348908794 1.1503521229267646 0.2978359786106364 0.05609670500601573 898.1381994391687 1143284.3979852118 0.018154624311760233 0.020618777612442685 5.240206364019575e-07 6.280651609773863 0.06892598803588523 NLS(ph)NEELTK ddPTM_A459_Selumetinib_30min_R2 4 NLSNEELTK 9 0 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 NLS(1)NEELTK;NLS(0.998)NEELT(0.002)K;NLS(0.995)NEELT(0.005)K;NLS(1)NEELTK 110.98 0.01054 253674000.0 1388310.0 1252170.0 1278970.0 1216310.0 1076780.0 840190.0 1054940.0 1060350.0 747450.0 1045650.0 True False 1311153.288045266 1348207.41263886 1196682.462637246 1050646.4797482165 941505.2698646638 955918.546014559 1103996.8003239518 1063435.4429496068 896960.8854979455 1015459.3675750257 1.2911922721008267 1.3276822841847975 1.1784641521353938 1.0346514230866959 0.9271717805046514 0.9413656287374123 1.0871895376378855 1.0472456869339348 0.8833055404668123 1.0 19.953701082349866 -5.621816418169959 2.268517894329633 0.9861610320767552 1.309949145445363 0.8447143864065693 0.056534173513731696 0.1150826560634639 1.1908735980920662 0.017443692628806375 0.03767106314667305 2.3888208546355067e-06 5.621816418169959 0.3237881133686077 NLS(ph)PGAVESDVR ddPTM_A459_Selumetinib_30min_R1 4 NLSPGAVESDVR 12 0 A0A3B3IU78;A0A3B3ISK1;A0A3B3ITV3;A0A3B3ISC6;A0A3B3IT15;A0A3B3IS84;P53621;P53621-2 A0A3B3IU78 COPA Coatomer subunit alpha;Xenin;Proxenin 1 NLS(1)PGAVESDVR;NLS(1)PGAVESDVR;NLS(1)PGAVESDVR;NLS(0.991)PGAVES(0.009)DVR 203.05 5.3897e-05 66056000.0 9570.6 11975.800000000001 11257.0 12327.6 11831.5 9524.0 10819.900000000001 10668.7 5584.299999999999 8339.6 True False 9793.576358854172 10573.667768601632 9728.361230274853 10174.81607771182 10761.34291402098 9428.197207100113 10003.746231848532 10385.73141917841 9476.149238865164 9410.068894583052 1.04075501131473 1.1236546604550803 1.0338246551919539 1.0812690312574649 1.143598738178824 1.0019264803180663 1.063089584562684 1.103682824804503 1.007022301857976 1.0 13.199989570156756 -8.282736051450257 20.750240769407434 1.0035107304447703 1.074092188689046 0.32765761170748176 0.040374691503221344 122.11241401121997 118969.12273599341 0.03745583773547901 0.00975751540739074 5.21511570763565e-09 8.282736051450257 0.07058145824427564 NLS(ph)PGAVESDVR ddPTM_A459_Selumetinib_30min_R2 3 NLSPGAVESDVR 12 0 A0A3B3IU78;A0A3B3ISK1;A0A3B3ITV3;A0A3B3ISC6;A0A3B3IT15;A0A3B3IS84;P53621;P53621-2 A0A3B3IU78 COPA Coatomer subunit alpha;Xenin;Proxenin 1 NLS(1)PGAVESDVR;NLS(0.999)PGAVES(0.001)DVR;NLS(0.991)PGAVES(0.009)DVR 157.07 0.00044122 29999300.0 72336.0 60453.0 76997.0 80800.0 77499.0 56529.0 63904.0 62051.0 50162.0 65125.0 True False 68315.85470395106 65089.55071296778 72043.09684799485 69794.90061222539 67762.88277014944 64315.35663082994 66875.66262337378 62231.558136903936 60195.80164338469 63244.67203492902 1.0801835554815007 1.0291704995642932 1.1391172494057145 1.1035696504786805 1.0714401796996447 1.0169292457601742 1.0574118020003238 0.9839810395812385 0.9517924547089044 1.0 15.948656326509727 -7.36318728096922 1.0481671583115746 0.9734387387404694 1.0857698312800201 0.6310685139026506 0.03317249603317644 0.3587765489991238 0.7504015962810324 0.025987444626024467 0.013599588758014886 4.33323975633909e-08 7.36318728096922 0.11233109253955076 NLS(ph)PSFSR ddPTM_A459_Selumetinib_30min_R1 1 NLSPSFSR 8 0 Q1ED39;H3BNU8 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 NLS(0.5)PS(0.5)FSR 98.04 0.019782 5453100.0 2092.2 3140.0 1991.7 2153.6 2214.0 2170.7 2626.6 1964.0 1496.0 2199.6 True False 2140.9441892874747 2772.3673402536037 1721.238079624982 1777.5141880787974 2013.7440909134475 2148.864728837905 2428.4734473122094 1911.908340028906 2538.602736483051 2481.940085918374 0.8626091344567156 1.1170162229068334 0.6935050887773889 0.7161793300989685 0.8113588649213169 0.8658004038976537 0.9784577238953048 0.7703281601664678 1.0228299832401921 1.0 11.277252573864548 -8.279575857005435 23.909549422797415 1.0114150927456418 0.8542694143326256 0.22668228621715703 0.11778083053846583 865.6055363379259 1141120.1507608618 0.11717758333312185 0.030545310434218716 5.253202508736801e-09 8.279575857005435 -0.1571456784130162 NLS(ph)PSNSCEPK ddPTM_A459_Selumetinib_30min_R2 1 NLSPSNSCEPK 11 0 A0A0G2JNU3;A6H8Y1-2;A6H8Y1-7;A6H8Y1-6;A6H8Y1 A0A0G2JNU3 BDP1 Transcription factor TFIIIB component B homolog 1 NLS(0.593)PS(0.345)NS(0.061)CEPK 96.756 0.019916 5074200.0 31221.0 26015.0 25783.0 25639.0 24059.0 16474.0 21420.0 25661.0 20985.0 25308.0 True False 29485.861807565467 28010.266848590734 24124.149850407863 22146.923970258034 21036.493329811045 18743.14396391751 22416.07244292479 25735.669261592753 25182.586369890123 24577.29228191916 1.199719703429552 1.1396807478746191 0.9815625567571307 0.9011132600050868 0.8559320973403981 0.7626203793697132 0.9120643635513779 1.0471320016210972 1.0246281844650666 1.0 14.585038360083981 -5.266900374260432 2.3790451672079245 0.9205735812638716 1.1945840669544836 0.5902680367038384 0.07946070381155582 0.23819877157401684 2.5427842999928822 0.024972827126758433 0.08524069106862495 5.408783844550327e-06 5.266900374260432 0.27401048569061204 NLS(ph)SDEATNPISR ddPTM_A459_Selumetinib_30min_R1 2 NLSSDEATNPISR 13 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 NLS(0.5)S(0.5)DEATNPISR;NLS(0.494)S(0.494)DEAT(0.013)NPISR 226.7 6.9053e-13 123873000.0 3058.1 3240.2 3737.0 3739.9 3580.1 2788.3 3108.3 3166.1000000000004 1740.13 2551.6000000000004 True False 3129.3477799732464 2860.8358776718865 3229.5359258716476 3086.796671617705 3256.2805871179903 2760.2522335738386 2873.838428493312 3082.1247430578005 2952.873515933321 2879.1227146887286 1.0869101771897105 0.9936484690549846 1.121708327816379 1.072130984855027 1.1309974981285358 0.9587129508205969 0.9981646193236374 1.0705082931454761 1.0256157199789817 1.0 11.49141356578292 -6.76007554279889 24.999999402317997 1.0142298589203262 1.0779818910887864 0.39573011242870737 0.04334553294631848 44.71571136309838 819670.7910302773 0.015178761381798028 0.014407554727863639 1.7374985754923637e-07 6.76007554279889 0.06375203216846015 NLS(ph)SDEATNPISR ddPTM_A459_Selumetinib_30min_R2 2 NLSSDEATNPISR 13 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 NLS(0.495)S(0.495)DEAT(0.01)NPISR;NLS(0.911)S(0.089)DEATNPISR 183.75 0.00012139 128843000.0 107517.0 104450.0 126769.0 129745.0 139382.0 100192.0 104419.0 96512.0 74523.0 104722.0 True False 101541.63556465264 112460.97914031535 118612.82055565123 112073.50717739078 121871.58706911022 113992.53854757927 109274.69040232326 96792.83394157825 89429.68234659635 101698.40375956745 0.9984584989624278 1.1058283609464754 1.1663193931349443 1.1020183506749217 1.1983628313108596 1.120888178511408 1.0744975964486863 0.9517635514753329 0.8793617111043703 1.0 16.633937509519846 -7.703369791093993 3.0458545638384753 0.9312335848245835 1.1192888476225116 0.6548160380206465 0.05572606782213177 0.14966841394368102 2.794622131868697 0.03241772456740394 0.015869197722896286 1.9798405222782847e-08 7.703369791093993 0.18805526279792806 NLSEGNNANYTEY(ph)VATR ddPTM_A459_Selumetinib_30min_R1 1 NLSEGNNANYTEYVATR 17 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 NLSEGNNANY(0.018)T(0.028)EY(0.953)VAT(0.001)R 168.45 1.6306e-05 5484000.0 1593.7 1964.9 2021.0 2135.9 1077.0 1965.1 1922.1 1092.2 797.54 1029.6 True False 1630.8301091996211 1734.8485945427715 1746.5593005583623 1762.9051608086477 979.5855401597936 1945.3328781680411 1777.114449508411 1063.2313080344056 1353.367129983083 1161.7591891532818 1.4037591649162764 1.493294488858032 1.5033746381049045 1.5174445593096584 0.8431915575152362 1.6744716945908962 1.5296753975353663 0.915190788212585 1.164929137310676 1.0 10.182095340824208 -7.760952890698486 24.999969079045503 1.0300449297837004 1.4202850701034346 0.41620575070895627 0.2153716417418299 13.254482796406903 681258.8855644132 0.11015677110307946 0.05856950346859341 1.733992079180018e-08 7.760952890698486 0.3902401403197342 NLSEGNNANYTEY(ph)VATR ddPTM_A459_Selumetinib_30min_R2 2 NLSEGNNANYTEYVATR 17 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 NLSEGNNANYTEY(1)VATR;NLSEGNNANYT(0.004)EY(0.996)VATR 309.29 6.708299999999999e-102 11473400.0 59148.0 54177.0 52831.0 55275.0 60520.0 45370.0 59951.0 49261.0 43038.0 57215.0 True False 55860.79094820422 58332.20169348843 49431.91097804358 47746.449645306464 52916.936544335345 51619.30567214626 62738.84029065282 49404.34135440246 51646.80258219352 55563.054287577215 1.0053585366111448 1.0498379263238296 0.8896543145774397 0.8593201050141265 0.9523763087330228 0.9290221053180532 1.1291467161962687 0.8891581283257187 0.9295169829017249 1.0 15.761838285643941 NLSELQDT(ph)SLQQLVSQR ddPTM_A459_Selumetinib_30min_R2 1 NLSELQDTSLQQLVSQR 17 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 NLSELQDT(0.5)S(0.5)LQQLVSQR 134.52 0.0010413 0.0 6451.7 6505.6 8638.8 8483.9 9029.5 6994.0 5591.6 5103.5 5724.0 5841.0 True False 6093.140342201413 7004.558601198998 8082.989013214264 7328.378184456189 7895.133485245808 7957.360014789304 5851.6204795451995 5118.350340070094 6868.95994192285 5672.355153259434 1.0741817424284847 1.2348589628020836 1.424979359511655 1.2919462879973542 1.3918616292403918 1.4028317691315337 1.0316033325562763 0.9023324883190716 1.2109537848623293 1.0 12.469732149010584 -7.274456527397283 23.996257982054747 1.0280833870536992 1.3093466093544752 0.549470789283596 0.11837600300493965 353.6627599951671 651950.4296698908 0.050499524802919714 0.034316717699116435 5.3154920458259836e-08 7.274456527397283 0.28126322230077605 NLSELQDTS(ph)LQQLVSQR ddPTM_A459_Selumetinib_30min_R2 1 NLSELQDTSLQQLVSQR 17 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 NLSELQDT(0.422)S(0.578)LQQLVSQR 131.48 0.0007803999999999999 1651600.0 17286.0 14926.0 16960.0 21104.0 19556.0 17505.0 17120.0 18627.0 13251.0 21579.0 True False 16325.313321340658 16070.776205345584 15868.812064651805 18229.59879356938 17099.200447141797 19916.15485543134 17916.113922636436 18681.201486134138 15901.570263874864 20955.958201024703 0.7790296757006503 0.7668833871103903 0.7572458349280279 0.8699005131952396 0.8159588926029486 0.9503814936249244 0.8549412892873768 0.8914505987715067 0.7588090275488959 1.0 14.355072869057182 -5.765962099303228 23.70979057913843 0.8723774325759588 0.7676359879965 0.38903425678123515 0.06274174648142623 59.37731096695004 311283.4564228086 0.01664608579505735 0.02569523164605711 1.7141068903686855e-06 5.765962099303228 -0.10474144457945878 NLSES(ph)PVITK ddPTM_A459_Selumetinib_30min_R1 1 NLSESPVITK 10 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 NLS(0.43)ES(0.545)PVIT(0.025)K 118.73 0.0056207 13699000.0 3895.5 4916.4 5042.0 5736.2 4675.7 3644.9 4404.2 3774.6 2294.0 3878.1 True False 3986.257570676494 4340.785602427647 4357.324093723533 4734.480351809807 4252.783760561882 3608.23561530441 4071.9876481582387 3674.485346371238 3892.7504528690597 4375.89191089291 0.910958874636163 0.9919773364653105 0.9957567925471019 1.0819463661852027 0.9718667296089799 0.8245714676640954 0.9305503268994916 0.8397111768744423 0.8895901754745892 1.0 12.095361387156201 -6.587959104905578 7.826713870413884 0.8894429720402949 0.9989007157657436 0.38400475184213745 0.059407652935664704 0.22933863239077598 23.97049924657068 0.01913968357152451 0.019142813803794165 2.582503359154668e-07 6.587959104905578 0.1094577437254487 NLSES(ph)PVITK ddPTM_A459_Selumetinib_30min_R2 2 NLSESPVITK 10 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 NLS(0.005)ES(0.991)PVIT(0.005)K;NLS(0.028)ES(0.97)PVIT(0.002)K 124.81 0.003732 33581000.0 222490.0 183278.0 238050.0 220660.0 225290.0 170673.0 197202.0 218832.0 185009.0 214450.0 True False 210124.89649803794 197334.8332683453 222734.12216924332 190605.72734026797 196987.05608184566 194181.65653476334 206372.28374834967 219468.7648904121 222015.9695833692 208258.2712919855 1.0089630303491541 0.9475485993623507 1.0695091281967004 0.9152372491992501 0.9458786671942686 0.932407895879025 0.99094399693258 1.0538297640179155 1.0660607533426365 1.0 17.668014269979416 -7.642883924527347 4.504212542509992 1.0445852453275755 0.9693030893314822 0.331532453461984 0.044184009682039185 0.23870018409475727 8.243905050770712 0.02221866626465764 0.012258248341806477 2.2757055856415724e-08 7.642883924527347 -0.07528215599609323 NLSGS(ph)TLYPVSNIPR ddPTM_A459_Selumetinib_30min_R2 1 NLSGSTLYPVSNIPR 15 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 NLS(0.097)GS(0.805)T(0.097)LYPVSNIPR 179.66 2.002e-05 9263500.0 16859.0 17352.0 22710.0 27803.0 27902.0 19427.0 17350.0 15573.0 16167.0 27740.0 True False 15922.044271924235 18682.842604526093 21248.86332477844 24016.183437149815 24396.701312955152 22102.89290925247 18156.809378372785 15618.31485175107 19400.851743722353 26939.07412282428 0.5910390312350859 0.6935220757530397 0.788774819353395 0.8914999575580057 0.9056250857665858 0.8204770813012342 0.6739953012338062 0.5797643519796535 0.7201751498684534 1.0 14.717412646780097 -11.983383380321927 2.1563454373175386 3.5043560317076405 0.7455375648385242 0.34572039306013 0.10688131169386947 6404418.535296541 309067.0849131684 78969247.41525592 0.032881956326793846 1.0390025649300928e-12 11.983383380321927 -2.7588184668691165 NLSGST(ph)LYPVSNIPR ddPTM_A459_Selumetinib_30min_R1 1 NLSGSTLYPVSNIPR 15 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 NLS(0.042)GS(0.282)T(0.662)LYPVS(0.013)NIPR 163.34 0.00024327 37674000.0 2087.8 2428.5 2812.9 2442.7 2091.9 2136.2 2005.3 1982.1 1123.8 1718.5 True False 2136.4416778483856 2144.1700910209806 2430.923630153695 2016.1283001579118 1902.6880143549429 2114.711767514411 1854.0386065237071 1929.52826923182 1907.0065208954886 1939.0862146075328 1.1017775598393376 1.1057631552782485 1.253643913221109 1.0397311295237959 0.9812291996207312 1.0905712967189674 0.9561403678479354 0.9950709023127952 0.9834562829283292 1.0 10.921161233863167 -5.951976381686825 10.015986852287032 1.0037209587959155 1.14885346093962 0.6431644009063568 0.050860198988553505 0.26762693442850377 53.73183746063332 0.014272882783005368 0.021176900014710637 1.1169239880025598e-06 5.951976381686825 0.14513250214370443 NLSPPNCT(ph)ELQIDSCSSSEEIKK ddPTM_A459_Selumetinib_30min_R1 1 NLSPPNCTELQIDSCSSSEEIKK 23 1 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2;A0A0A0MSN1;A0A0U1RRA9 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NLS(0.051)PPNCT(0.947)ELQIDS(0.001)CS(0.001)S(0.001)S(0.001)EEIKK 52.909 0.035204 6635800.0 867.14 940.78 1104.3 1072.8 1023.1 1060.8 963.45 852.6 614.42 604.89 True False 887.3426748392794 830.6330402432434 954.3421254857002 885.4556189500986 930.5607856429757 1050.1293151293369 890.7761908219553 829.9862783648913 1042.625864538714 682.5335236275534 1.300071929248543 1.216984970684759 1.3982348008542185 1.297307147997724 1.3633920583082837 1.5385754380943404 1.3051024748024482 1.216037380777505 1.5275819112844875 1.0 9.414756097614484 -10.69574961165643 4.714375193948232 0.9999561537734006 1.3478087825799459 0.4964985332942613 0.10612612286620178 4.875108299042631e-05 8.553314572146263e-06 0.1024236464286862 0.0248382576642726 2.0148855781267485e-11 10.69574961165643 0.3478526288065452 NLSPPNCT(ph)ELQIDSCSSSEEIKK ddPTM_A459_Selumetinib_30min_R2 1 NLSPPNCTELQIDSCSSSEEIKK 23 1 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2;A0A0A0MSN1;A0A0U1RRA9 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NLS(0.372)PPNCT(0.628)ELQIDSCSSSEEIKK 90.464 0.00020987 4956300.0 12175.0 11003.0 10658.0 10597.0 9386.8 8837.1 7636.8 7377.9 4966.4 8517.4 True False 11498.36224038659 11846.894719778738 9972.275883553004 9153.67031915536 8207.546264943272 10054.330309793331 7991.926332032119 7399.3684675229 5959.818772810212 8271.480531137115 1.3901214174538912 1.4322580673656131 1.2056216352094917 1.1066543993783622 0.992270517236525 1.215541797135938 0.966202640742169 0.8945639707025554 0.720526240783026 1.0 13.01392986844295 -5.4163326308518105 0.428570860740444 0.8689515976981503 1.6663559525130531 0.7434545430207187 0.10675645040803843 1.6399709219441048 0.3514216042803658 0.09300945412042057 0.6336561615225598 3.834134724695765e-06 5.4163326308518105 0.7974043548149028 NLSPS(ph)FSR ddPTM_A459_Selumetinib_30min_R1 1 NLSPSFSR 8 0 Q1ED39;H3BNU8 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 NLS(0.291)PS(0.709)FSR 95.523 0.022239 0.0 1889.2 2911.1 1948.6 1991.5 1603.3 1860.4 2241.4 2263.7 1192.8 1719.8 True False 1933.2146842567136 2570.267058666327 1683.9908228936285 1643.7219100849381 1458.281798085606 1841.6860651080476 2072.3293934385074 2203.6593224661083 2024.0944813348801 1940.5530822706032 0.9962183987230573 1.3245023195443373 0.8677891052190254 0.8470378497256315 0.7514774068325402 0.9490521449447427 1.0679065738380706 1.1355831193690664 1.0430503034560263 1.0 10.922252182089048 -9.538014818351787 13.97728417070391 0.9999998271698183 0.9968000054244385 0.0 0.15342121203187567 0.0 0.0 0.16292758648588296 0.03951574402401483 2.8972447305298314e-10 9.538014818351787 -0.003199821745379805 NLSPS(ph)FSR ddPTM_A459_Selumetinib_30min_R2 2 NLSPSFSR 8 0 Q1ED39;H3BNU8 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 NLS(0.032)PS(0.968)FS(0.001)R;NLS(0.01)PS(0.99)FSR 139.38 0.0024082 27994000.0 169692.0 155778.0 160279.0 204112.0 194572.0 163641.0 186156.0 180714.0 152248.0 193555.0 True False 160261.19797089795 167725.67169478282 149966.8236385808 176311.59348716063 170128.12586425003 186181.0623649039 194812.62286111608 181239.84782118673 182701.85416454778 187966.564233715 0.8526048163099444 0.8923165264979523 0.7978377657215362 0.9379944470759025 0.9050978111868614 0.9905009602314641 1.0364216830546988 0.9642132288795556 0.971991241683701 1.0 17.520116530466098 -6.37891220762146 1.4349489321827416 0.9933792406037568 0.8559660967848118 0.7283204729218066 0.03616472224512169 0.21320669243103707 0.8874863096178937 0.014126767698439667 0.017708482931320834 4.179148393515436e-07 6.37891220762146 -0.13741314381894498 NLSS(ph)DEATNPISR ddPTM_A459_Selumetinib_30min_R2 2 NLSSDEATNPISR 13 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 NLS(0.076)S(0.749)DEAT(0.175)NPISR;NLS(0.259)S(0.741)DEATNPISR 218.34 1.6474e-08 135108000.0 179566.0 150499.0 205180.0 212018.0 190681.0 151470.0 137874.0 159430.0 115300.0 143078.0 True False 169586.44057965174 162041.7893694429 191978.94218309328 183140.7826485494 166725.94807023142 172333.61759224153 144285.4141921481 159893.91490494262 138363.22175117172 138946.9663787116 1.2205120054037717 1.1662132221568942 1.3816706271933896 1.3180624767969662 1.1999250679270383 1.2402834123238922 1.038420758312104 1.150754989994804 0.9957987954486978 1.0 17.08417481103959 -7.296047489854995 1.176983559438853 1.0293391519971196 1.269582695445618 0.6750154221286159 0.07029363691754144 0.3116755906642878 0.8355536418568343 0.04963093700094088 0.02748855958940726 5.057693533875789e-08 7.296047489854995 0.2402435434484984 NLTANDPSQEYVAS(ph)EGEEDPEVEFLK ddPTM_A459_Selumetinib_30min_R2 2 NLTANDPSQEYVASEGEEDPEVEFLK 26 0 Q86X95 Q86X95 CIR1 Corepressor interacting with RBPJ 1 1 NLTANDPSQEY(0.002)VAS(0.998)EGEEDPEVEFLK;NLTANDPSQEY(0.001)VAS(0.999)EGEEDPEVEFLK 104.31 8.2355e-07 3269200.0 21735.1 24113.0 24193.2 26207.0 26438.0 18313.0 20996.6 22096.5 15736.5 22798.8 True False 20527.150154499093 25962.389564484674 22636.635851564482 22637.56139040339 23116.622081281184 20835.449521137616 21972.9835039736 22160.797156727513 18884.239714547333 22140.539405603704 0.9271296321400252 1.1726177528409119 1.022406700978352 1.0224485038821542 1.0440857676408026 0.9410542868645841 0.9924321671409823 1.0009149619506867 0.8529259097349629 1.0 14.434402750192396 -6.688933025443863 1.1534611013722362 0.9533115655102311 1.0513486874507012 0.22129588386600185 0.07013194572085563 0.6692957446373055 1.8904928340569394 0.03388906100984469 0.032806932247400944 2.0467602527312443e-07 6.688933025443863 0.0980371219404701 NLTMS(ph)PLHK ddPTM_A459_Selumetinib_30min_R2 1 NLTMSPLHK 9 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 NLT(0.077)MS(0.923)PLHK 82.705 0.026898 13385000.0 86566.0 85497.0 90221.0 106500.0 107600.0 71270.0 84266.0 81302.0 60729.0 91848.0 True False 81755.00827115455 92054.34498381546 84416.27908519741 91994.51627725273 94082.32604379527 81086.7955753551 88184.53596991126 81538.57535972941 72876.49691003372 89196.10959023649 0.9165759431295146 1.0320443952848346 0.9464121190150845 1.0313736406203367 1.0547806005890377 0.9090844426720486 0.9886589939295294 0.9141494593689624 0.817036721050117 1.0 16.444693165958782 -7.820576900732625 4.6182831835490825 0.8957602580589344 0.9852098812744016 0.21564105041196957 0.06192045538934721 0.2656618922907168 11.318932356898875 0.033842450327415105 0.015946412397608876 1.51155202441946e-08 7.820576900732625 0.08944962321546712 NLTVLDAIY(ph)EVSR ddPTM_A459_Selumetinib_30min_R1 1 NLTVLDAIYEVSR 13 0 Q4W5G0 Q4W5G0 TIGD2 Tigger transposable element-derived protein 2 1 NLTVLDAIY(1)EVSR 140.49 0.012293 7854700.0 346.25 373.02 632.92 637.31 462.73 427.58 355.08 296.89 193.88 251.95 True False 354.3169513147826 329.34664498770684 546.9729403807015 526.0157722903505 420.8761532016166 423.2789334115776 328.2960297234518 289.01551276536776 329.00019956506276 284.2902367008248 1.2463212083067454 1.1584873571803225 1.923994811528871 1.8502773025016248 1.4804453296949807 1.488897185931217 1.1547917843866615 1.0166213096847068 1.1572687243258688 1.0 8.151220743573258 -7.280767024753564 2.6548085384082114 1.0635411284568774 1.548058987109564 0.49055542440773314 0.22256337254536243 0.2765494713684303 3.8666543724756077 0.11567446667258573 0.0764624926983494 5.238813949471335e-08 7.280767024753564 0.4845178586526866 NLVS(ph)PAYCTQESR ddPTM_A459_Selumetinib_30min_R1 1 NLVSPAYCTQESR 13 0 Q9NUQ3 Q9NUQ3 TXLNG Gamma-taxilin 1 NLVS(0.577)PAYCT(0.422)QESR 91.592 0.019582 13731000.0 1810.9 2188.7 2497.5 2412.1 1930.3 1797.2 2323.4 1957.1 1305.3 1783.4 True False 1853.090446601992 1932.445986500976 2158.3532177855072 1990.8720157247703 1755.7047058221456 1779.12179972704 2148.1440674199275 1905.191350443266 2214.9987646599766 2012.316761787065 0.9208741296555767 0.9603090443796937 1.0725713062533717 0.9893432552620343 0.8724792931024281 0.8841161756994297 1.0674979745794293 0.9467651349041764 1.1007207248489632 1.0 10.974641704462417 -7.275544182570961 24.986450741503006 1.024309716038647 0.9542628382098758 0.25805824418052636 0.06503536870793977 1416.3897750555684 2509103.450583477 0.028898198414115714 0.019585532296262993 5.302196484510246e-08 7.275544182570961 -0.07004687782877117 NLVS(ph)PAYCTQESR ddPTM_A459_Selumetinib_30min_R2 3 NLVSPAYCTQESR 13 0 Q9NUQ3 Q9NUQ3 TXLNG Gamma-taxilin 1 NLVS(1)PAYCTQESR;NLVS(0.989)PAYCT(0.011)QESR;NLVS(0.978)PAY(0.005)CT(0.017)QESR 180.56 0.0001126 42506000.0 106972.0 115816.0 110067.0 127543.0 130102.0 93728.0 99079.0 108268.0 86936.0 137012.0 True False 101026.92448284483 124698.71479286534 102985.40905188852 110171.42337605282 113757.42363336269 106638.1812219292 103686.36982131396 108583.04195526772 104325.62919479459 133056.10756007239 0.7592806248088464 0.9371889579481811 0.7739998632185486 0.8280072624724306 0.8549583008206016 0.8014527343194977 0.7792680225107402 0.8160695810693581 0.7840724571601757 1.0 17.02167520910657 -11.012103637496631 6.819965850971664 1.000059961495124 0.8174658275101399 0.5622390621039757 0.04894670712196097 4.268509376054149e-05 3.196842988223572e-06 0.04533173628010114 0.010990960286593758 9.725151207603224e-12 11.012103637496631 -0.18259413398498414 NLYIIS(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 NLYIISVK 8 0 C9JD32;J3KT29;P62829;B9ZVP7 C9JD32 RPL23 60S ribosomal protein L23 1 NLYIIS(1)VK 89.171 0.030042000000000006 9132100.0 1107.6 2585.1 2384.5 3322.8 2026.3 2129.4 2175.9 1359.7 718.89 1441.8 True False 1133.404924985569 2282.435290219615 2060.6979971209366 2742.535356681012 1843.021522772322 2107.9801693405047 2011.77011117286 1323.6363390719473 1219.9038243518046 1626.8690743212906 0.6966786343630089 1.4029618770470627 1.266664926912225 1.6857750878479043 1.132864071155331 1.295728219690898 1.23659005074649 0.8136096259769102 0.749847571391529 1.0 10.667882436454528 -7.743185845596649 6.788820054705318 0.8349544731273904 1.267954774466585 0.3553618631411277 0.23954716376806887 0.15376335709038688 28.916165821026915 0.11761323747260231 0.06404665627634044 1.8064009559214214e-08 7.743185845596649 0.43300030133919476 NLYPSS(ph)SPYTR ddPTM_A459_Selumetinib_30min_R1 2 NLYPSSSPYTR 11 0 Q9Y2Z0-2;Q9Y2Z0 Q9Y2Z0-2 SUGT1 Suppressor of G2 allele of SKP1 homolog 1 NLYPS(0.128)S(0.436)S(0.436)PYTR;NLYPS(0.173)S(0.655)S(0.173)PYTR 120.55 0.0046978 39796000.0 6083.4 6649.1 7075.6 6513.6 6520.200000000001 5622.8 7169.3 5872.3 3544.0 6109.1 True False 6225.131383764182 5870.620280917269 6114.772383488738 5376.122035415141 5930.449061234806 5566.239737093924 6628.51392896346 5716.54752808134 6013.909156481234 6893.262492673187 0.9030747618244397 0.8516461236108622 0.8870650711456438 0.7799096641291976 0.8603254362558005 0.8074898849434867 0.9615931405497575 0.8292949142960142 0.872432924594615 1.0 12.75097123827308 -8.573840755063772 19.239820101229196 1.0000000008867505 0.8590923150215093 0.42978198068930296 0.048063400197929665 1484.1517354622683 560316.3119930592 0.04502831942144992 0.0116262620705087 2.66783671426799e-09 8.573840755063772 -0.14090768586524116 NLYPSSS(ph)PYTR ddPTM_A459_Selumetinib_30min_R2 3 NLYPSSSPYTR 11 0 Q9Y2Z0-2;Q9Y2Z0 Q9Y2Z0-2 SUGT1 Suppressor of G2 allele of SKP1 homolog 1 NLYPS(0.064)S(0.214)S(0.722)PYTR;NLYPS(0.002)S(0.008)S(0.99)PYTR;NLYPS(0.118)S(0.406)S(0.476)PYTR 182.37 3.6868e-05 44416900.0 158949.0 162110.0 163985.0 189045.0 178091.0 135317.0 158101.0 141777.0 126224.0 161821.0 True False 150115.2509032615 174543.31573419383 153434.38363336792 163296.74487918543 155717.6164262596 153955.68846457585 165453.0097711884 142189.5475975543 151472.32699323396 157148.8072685493 0.9552426996581128 1.1106881354557105 0.9763636536621378 1.0391217580171004 0.9908927667529543 0.97968092243604 1.052842924149263 0.9048083155640415 0.9638783114299118 1.0 17.26177179681669 -7.756643889654293 24.99998532974903 0.9507574856642452 1.0158171448856563 0.23899681227680813 0.047723924926503646 146.76591098897512 765137.6354213046 0.021912706557894093 0.012123721954966101 1.7512821064893648e-08 7.756643889654293 0.0650596592214111 NLYSDDIPHALR ddPTM_A459_Selumetinib_30min_R1 1 NLYSDDIPHALR 12 0 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 93.766 0.027889 3963300.0 3113.2 3549.2 3576.9 3493.3 2590.4 3543.5 2978.5 3255.5 2765.8 3931.8 False True 3185.7315027673085 3133.658014021684 3091.1766265052966 2883.2607323623993 2356.0987773722645 3507.8556072405786 2753.829346995893 3169.1535646456746 4693.360593960442 4436.484828975205 0.7180755993936733 0.7063380434787907 0.6967625824653919 0.6498975751097994 0.5310733312969551 0.7906835574710771 0.6207232647366016 0.7143388711593375 1.0579007423416735 1.0 12.115201319714803 -8.221784571685028 5.196112724339783 1.031233364181801 0.6740895543072964 0.8190530768577642 0.06598595978326553 0.06932747025980839 4.795348730166597 0.04897481711225637 0.01671100444814059 6.0008867164035695e-09 8.221784571685028 -0.35714380987450456 NMAPGAVCS(ph)PGESK ddPTM_A459_Selumetinib_30min_R1 3 NMAPGAVCSPGESK 14 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 NMAPGAVCS(0.711)PGES(0.289)K;NMAPGAVCS(0.999)PGES(0.001)K;NMAPGAVCS(0.713)PGES(0.287)K 191.51 0.00010681 54506000.0 11569.7 13843.699999999999 14338.0 14925.2 13027.099999999999 11473.5 12511.7 12226.5 8470.23 10535.369999999999 True False 11839.251499282722 12222.873168238471 12390.978352996428 12318.79400070286 11848.801105121313 11358.087007104494 11567.932395772546 11902.21350273088 14373.361668877555 11887.687362694069 0.9959255436374153 1.0281960481730268 1.0423371657536844 1.03626497104573 0.9967288626974841 0.9554496733105914 0.973102004017621 1.0012219483566163 1.2090965408447758 1.0 13.537180459234607 -8.146075020390517 23.59092703164668 1.1048149439050468 1.003989641265466 0.3645028344300667 0.05328676010553071 11.847184487261599 2388.287091769147 0.0345794096792387 0.013069786932147385 7.1437291404451555e-09 8.146075020390517 -0.10082530263958067 NMAPGAVCS(ph)PGESK ddPTM_A459_Selumetinib_30min_R2 4 NMAPGAVCSPGESK 14 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 NMAPGAVCS(0.721)PGES(0.279)K;NMAPGAVCS(0.942)PGES(0.058)K;NMAPGAVCS(0.93)PGES(0.07)K;NMAPGAVCS(0.919)PGES(0.081)K 186.96 1.5547e-06 69094000.0 229488.0 236343.0 239566.0 253987.0 232962.0 180357.0 212066.0 222231.0 158233.0 240444.0 True False 216733.9756732514 254469.7481374781 224152.58437973907 219393.53244798636 203695.23085329586 205199.53963216415 221927.48920080715 222877.65541767742 189884.0213994199 233501.7569714623 0.9281899137904123 1.0897980016851798 0.9599610182253753 0.939579792861258 0.8723498850511463 0.8787922724591869 0.9504317743867352 0.954500978101491 0.813201681487248 1.0 17.833073879894144 -5.664431982115631 2.8590900677140993 0.9105141576305409 1.0111485411719994 0.26605545240352013 0.06134871760208976 0.30013757639891 4.918958598006158 0.016780698722815533 0.03207860568106737 2.1655490144677553e-06 5.664431982115631 0.10063438354145848 NMAPSQQS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 5 NMAPSQQSPVR 11 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 NMAPSQQS(1)PVR;NMAPSQQS(1)PVR;NMAPS(0.003)QQS(0.997)PVR;NMAPSQQS(1)PVR;NMAPS(0.138)QQS(0.862)PVR 182.72 1.0749e-12 159852000.0 106723.2 93396.5 111613.4 107741.4 107728.0 77858.2 94900.2 97830.8 71511.0 85259.7 True False 100791.95179081935 100559.71123291965 104432.31535948133 93066.83545571825 94194.24553946068 88582.46032363012 99313.24734117872 98115.47143123925 85815.19818428479 82798.03092969589 1.2173230529648968 1.214518148605554 1.2612898421238448 1.1240223277138275 1.1376387153390322 1.069861919770119 1.1994638788633267 1.1849976422090214 1.0364400846337853 1.0 16.33730883807427 -1.5228788023851272 0.021247855671456685 1.7820036328239993e-11 2.6455683683107654 0.5872164766864472 0.05262911117821953 2094.9904492219116 3.441599085520569 156.02650621788405 292.0898380680832 0.02999999605534114 1.5228788023851272 2.6455683682929454 NMDDDRLSR ddPTM_A459_Selumetinib_30min_R1 1 NMDDDRLSR 9 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 93.598 0.037167 0.0 1951.9 1440.4 3993.3 4506.4 3131.9 2316.1 1910.2 1806.7 1254.0 1420.9 False True 1997.3754722637511 1271.757298376207 3451.0317936267734 3719.4418356047054 2848.620197981854 2292.802136850542 1766.1120760891565 1758.7804470113167 2127.946411463734 1603.286355738052 1.2458008297240735 0.7932190614762452 2.1524737494807256 2.3198861652462006 1.7767382525191695 1.4300640235880262 1.1015574789670994 1.0969846033534572 1.3272403921158311 1.0 10.646816406416503 -7.04148614269 3.5736000954476634 1.143249689521693 1.6716934261708205 0.26693464140200573 0.4094919956439046 0.38548767716669496 10.10862713821957 0.18336154307064498 0.14543219211615105 9.088952993027793e-08 7.04148614269 0.5284437366491275 NMGGPYGGGNYGPGGS(ph)GGSGGYGGR ddPTM_A459_Selumetinib_30min_R1 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 NMGGPYGGGNYGPGGS(0.505)GGS(0.495)GGYGGR;NMGGPYGGGNYGPGGS(0.988)GGS(0.012)GGYGGR 161.64 1.2483e-12 11789000.0 4133.3 4628.700000000001 5427.5 5223.9 4450.5 4413.4 4639.1 4885.3 2535.7599999999998 3893.8 True False 4229.5978479982405 4086.769652175752 4690.475311123457 4311.643929747786 4047.9530607995957 4369.005203046583 4289.168952039165 4755.725974309174 4302.999515417283 4393.607158823863 0.9626709205222784 0.9301627351840329 1.0675682057061886 0.9813448890369121 0.9213279463708821 0.9944005108131093 0.9762295073252166 1.082419479574557 0.9793773908018588 1.0 12.101190165949667 -7.624069399106494 20.166249704995355 1.0244167390145584 0.9767342949713268 0.16955069026159908 0.04473322786297595 5.484334476734796 1078.5032049795245 0.021060675681065153 0.012159327015635097 2.3764605041951842e-08 7.624069399106494 -0.04768244404323163 NMGGPYGGGNYGPGGS(ph)GGSGGYGGR ddPTM_A459_Selumetinib_30min_R2 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 NMGGPYGGGNYGPGGS(0.873)GGS(0.127)GGYGGR;NMGGPYGGGNYGPGGS(0.553)GGS(0.447)GGYGGR 203.29 8.672399999999997e-31 48163000.0 41570.0 37229.0 43446.0 38100.0 45964.0 31348.0 30737.0 31962.0 25519.0 36443.0 True False 39259.70581789493 40084.34458989755 40650.73166042819 32910.714273834055 40189.59139662641 35665.90245118891 32166.33140421004 32055.00412840605 30623.513060434896 35390.795899714714 1.109319664048906 1.132620602924069 1.1486243987170652 0.9299229767844625 1.135594449769082 1.0077733926146717 0.908889743405554 0.9057440872264884 0.8652959698112286 1.0 15.111086586287445 -7.05954077755403 3.149705422278702 0.9122159498030986 1.0878165505871082 0.5948251347796325 0.06622649967757703 0.1813758808978427 3.552353288207292 0.027066336015297968 0.021121568798582766 8.718850328551965e-08 7.05954077755403 0.17560060078400963 NMGGPYGGGNYGPGGSGGS(ph)GGYGGR ddPTM_A459_Selumetinib_30min_R1 3 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 NMGGPYGGGNYGPGGS(0.201)GGS(0.799)GGYGGR;NMGGPYGGGNYGPGGSGGS(1)GGYGGR;NMGGPYGGGNYGPGGSGGS(1)GGYGGR 337.51 2.926899999999998e-191 100435000.0 4454.5 5005.0 5718.4 5772.0 4967.4 4109.76 4780.3 4524.8 2556.89 3920.51 True False 4558.281183051841 4419.012273238627 4941.872688922782 4764.028553859034 4518.099547065699 4068.419545763521 4419.718122358392 4404.787605378205 4338.855582143146 4423.745647501293 1.0304121317704011 0.9989300075908886 1.117124057915524 1.0769218968432206 1.0213289612655965 0.9196775470265849 0.9990895667464118 0.9957144818817065 0.9808103647626992 1.0 12.111052721853675 -6.5267274525539865 24.934879538969486 0.9789825722105182 1.0552793303645964 0.5082732051026777 0.03568361233359843 95.76830388456408 620452.5046092612 0.012315055558355941 0.012369303515069992 2.973531526724659e-07 6.5267274525539865 0.07629675815407821 NMGGPYGGGNYGPGGSGGS(ph)GGYGGR ddPTM_A459_Selumetinib_30min_R2 5 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 NMGGPYGGGNYGPGGS(0.17)GGS(0.83)GGYGGR;NMGGPYGGGNYGPGGS(0.105)GGS(0.895)GGYGGR;NMGGPYGGGNYGPGGS(0.241)GGS(0.759)GGYGGR;NMGGPYGGGNYGPGGS(0.115)GGS(0.885)GGYGGR;NMGGPYGGGNYGPGGS(0.246)GGS(0.754)GGYGGR 186.05 5.4931e-26 53495900.0 57636.9 59275.4 62733.2 70357.3 64187.3 46086.9 55293.7 50599.299999999996 41861.600000000006 59149.1 True False 54433.67183679159 63821.63257954856 58697.01421074373 60774.514366887815 56123.517532257414 52434.952139775975 57864.96661238792 50746.53558583495 50235.0897108312 57441.311795181915 0.9476397758965769 1.1110754713805442 1.0218606152317562 1.0580279674599193 0.9770584232542713 0.9128439184457158 1.007375437711392 0.8834501511173964 0.8745463524571672 1.0 15.809801076112809 -6.475766153555238 3.7052580271666495 0.9331332097808026 1.0387322402467498 0.41340775579601896 0.05532232133874034 0.21927840265323828 6.166078981088157 0.01784231976787019 0.019583725514045847 3.3437503624774295e-07 6.475766153555238 0.10559903046594721 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_A459_Selumetinib_30min_R2 1 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 145.8 1.4829000000000003e-08 2625500.0 1897.5 2602.0 2005.8 2229.7 2970.3 1004.1 2003.7 2092.7 853.42 1908.8 False True 1792.0445462943364 2801.5650332513223 1876.749011749916 1926.011013552959 2597.144359181085 1142.4056606877236 2096.8760202562285 2098.789410534866 1024.1278465471346 1853.6879843419974 0.9667455156593991 1.5113466003534528 1.0124406197821392 1.039015751206174 1.4010687780894213 0.6162880001044203 1.1311914615449996 1.1322236688500045 0.5524812456022197 1.0 10.856182712376999 -6.75122206130829 24.99949871748595 0.9099979849037569 1.1863696598500293 0.2792327709874959 0.2392488764842368 303.6991654847922 743082.9205466126 0.07739884688209635 0.0765657651253893 1.7732825429777518e-07 6.75122206130829 0.27637167494627235 NMGLS(ph)PPASSTSTSSTCR ddPTM_A459_Selumetinib_30min_R1 1 NMGLSPPASSTSTSSTCR 18 0 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 NMGLS(0.698)PPAS(0.088)S(0.029)T(0.073)S(0.024)T(0.024)S(0.024)S(0.038)T(0.002)CR 86.573 0.007205800000000002 10815000.0 1853.4 2162.4 2787.5 2221.6 1836.1 2239.6 2304.1 2143.9 1382.2 2093.2 True False 1896.5806139113877 1909.225202727513 2408.9728106414823 1833.6392645968858 1670.0250791897845 2217.0716573941004 2130.2998819584473 2087.036807631352 2345.492448106199 2361.882609494609 0.8029952912508274 0.8083488972112993 1.0199375705454512 0.7763464861571779 0.7070737014940524 0.9386883363642299 0.9019499417095436 0.8836327424748397 0.9930605520687088 1.0 11.205721546218221 -7.95417952688535 0.9423639626408467 1.0030841051253603 0.8383290308031071 0.3396578617367061 0.08219588529548492 0.7015893236840596 1.1642841993412427 0.07926620446796563 0.03053144568373356 1.1112722591179989e-08 7.95417952688535 -0.16475507432225323 NMGLS(ph)PPASSTSTSSTCR ddPTM_A459_Selumetinib_30min_R2 2 NMGLSPPASSTSTSSTCR 18 0 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 NMGLS(0.943)PPAS(0.022)S(0.022)T(0.009)S(0.002)TSSTCR;NMGLS(0.913)PPAS(0.043)S(0.014)T(0.017)S(0.005)T(0.005)S(0.002)ST(0.001)CR 167.14 1.3499e-07 25074000.0 72391.0 69241.0 80773.0 86939.0 93338.0 67345.0 69775.0 72646.0 62935.0 78282.0 True False 68367.7980241335 74551.56205509421 75576.15311899276 75097.75822185988 81612.04598769284 76621.16245295771 73019.67575653955 72857.38783280728 75523.7585508238 76021.7952589378 0.8993183835144379 0.980660372478237 0.9941379687440012 0.9878451037109746 1.0735348423398066 1.007884149433441 0.9605097526022277 0.9583749973892062 0.9934487641811452 1.0 16.214125474475516 -4.710241837041131 2.5564220640090336 0.9969357624093742 0.8664833494595912 0.48770962611998514 0.02986949975922688 0.6547100458680892 4.597783145230315 0.008609728422172972 0.20167355131471007 1.948759130329406e-05 4.710241837041131 -0.13045241294978305 NMGYLNS(ph)SPLSR ddPTM_A459_Selumetinib_30min_R2 1 NMGYLNSSPLSR 12 0 Q9P2B7 Q9P2B7 CFAP97 Cilia- and flagella-associated protein 97 1 NMGYLNS(0.5)S(0.5)PLSR 151.16 0.00052989 2189700.0 16617.0 15809.0 19332.0 19111.0 21863.0 17790.0 16448.0 16811.0 14543.0 17867.0 True False 15693.493663121471 17021.49946605309 18088.200167090123 16508.04883168616 19116.37448230014 20240.41101845892 17212.8645910937 16859.91722678914 17452.00636537107 17351.133285958967 0.904465051618334 0.9810021734907295 1.0424794662679244 0.9514104098920699 1.1017363631094723 1.1665180991283168 0.9920311432926887 0.9716896844099899 1.0058136305997796 1.0 14.082742274781651 -4.475292640034923 1.1866676643387633 1.0339985605029447 0.7547562082606992 0.28512764359593645 0.060533589423825425 4.0437674924699065 3.0045236253919825 0.019976532706027197 1.6607413635259964 3.347398058985385e-05 4.475292640034923 -0.2792423522422455 NMPGLSAATLASLGGTSS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 NMPGLSAATLASLGGTSSR 19 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3;C9JTC6;Q32MZ4-4 Q32MZ4-2;Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 NMPGLSAATLAS(0.001)LGGT(0.08)S(0.233)S(0.686)R;NMPGLSAATLAS(0.009)LGGT(0.143)S(0.143)S(0.705)R 120.15 0.00043828 137903000.0 3576.1 9602.9 1920.5 3782.8 3681.8999999999996 3263.6 3225.1 3423.8 4032.5 3150.4 True False 3659.416172120707 8478.588003732908 1659.7066485513785 3122.204991950441 3348.8727950922403 3230.7711471117095 2981.8281104570938 3332.989701930229 6842.85797785287 3554.7845274946567 1.029434032869439 2.3851200932587755 0.4668937415796359 0.8783106170856749 0.9420747640792904 0.9088514710591178 0.838821055789457 0.9376066752150672 1.9249712394454424 1.0 11.79554639850506 -5.269781281660185 24.999471497379133 0.9713662037214693 1.7072770894275922 0.28118437515221417 0.4599729496712419 659.6757636279575 1976956.6429650597 0.11536518660166935 0.24662969281838384 5.373023231439646e-06 5.269781281660185 0.7359108857061228 NMPGLSAATLASLGGTSS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 NMPGLSAATLASLGGTSSR 19 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3;C9JTC6;Q32MZ4-4 Q32MZ4-2;Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 NMPGLSAATLASLGGT(0.008)S(0.086)S(0.906)R;NMPGLSAATLASLGGT(0.02)S(0.381)S(0.599)R;NMPGLSAATLASLGGT(0.258)S(0.187)S(0.555)R 203.58 9.5871e-16 49866200.0 219371.0 146851.0 189553.0 242155.0 194575.0 139354.0 147506.0 158868.0 101140.0 144094.0 True False 207179.23803169152 158113.99949961164 177357.36634970218 209173.07125932534 170130.74897742967 158548.74857033853 154365.32127759416 159330.27957798683 121370.82608771417 139933.6318188265 1.4805535691371792 1.1299213594650601 1.2674391713017823 1.4948019896327984 1.2157959939015923 1.1330281827860595 1.1031323869121936 1.138613194748446 0.8673456445756672 1.0 17.09438321769028 -7.250267138031336 0.8786208153429602 0.9694825391015739 1.3252621921172545 0.602852517636415 0.11633130610008764 0.4515660061298402 0.6806406534953284 0.09187173058663073 0.05425961576077584 5.619955308764293e-08 7.250267138031336 0.3557796530156806 NMPLVETIAAMERR ddPTM_A459_Selumetinib_30min_R1 1 NMPLVETIAAMERR 14 1 A6NK97 A6NK97 SLC22A20 Solute carrier family 22 member 20 0 107.11 0.020873 11261000.0 1125.2 1364.0 1235.8 1484.9 1380.9 1191.6 1181.0 1368.7 710.89 1066.1 False True 1151.4149707419308 1204.302245893604 1067.985147763495 1225.59009002517 1255.9978388176967 1179.6135858862344 1091.916219171445 1332.3976298358273 1206.3284086486867 1202.9443196933896 0.9571639783256196 1.0011288354564578 0.8878092944781572 1.0188252855606421 1.044103054693196 0.9806053086371431 0.9077030426892544 1.107613717462362 1.0028131717319715 1.0 10.232354151148403 -5.857486231375794 22.42791892366763 1.0093776134774357 0.9537766083349136 0.206493335217954 0.05371043298879833 11.874578870322079 2757.2190706986257 0.015381244987978838 0.02281411993716469 1.3883973261871523e-06 5.857486231375794 -0.055601005142522086 NMPNKQPES(ph)SL ddPTM_A459_Selumetinib_30min_R2 1 NMPNKQPESSL 11 1 Q9Y6M5 Q9Y6M5 SLC30A1 Zinc transporter 1 1 NMPNKQPES(0.5)S(0.5)L 108.68 0.046659 4740200.0 68031.0 34558.0 53263.0 64038.0 49311.0 37159.0 65466.0 50935.0 35688.0 52490.0 True False 64250.10936967059 37208.48747851622 49836.11656836963 55315.91392828835 43116.111334066765 42277.31495418297 68510.29871841804 51083.2124172568 42826.597206034734 50974.47731460156 1.260436845151647 0.7299434822818263 0.9776680251333182 1.0851688304108063 0.8458372425864232 0.8293820198147025 1.3440117942865766 1.0021331283493926 0.8401576526566389 1.0 15.637487456667273 NMQNVEHVPLSLDR ddPTM_A459_Selumetinib_30min_R1 3 NMQNVEHVPLSLDR 14 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 ;; 178.95 0.010657 39823400.0 11814.31 12792.77 13430.13 14331.54 12630.34 11557.630000000001 11482.11 11733.57 5682.29 10420.42 False True 12089.560436354514 11294.986541202574 11606.392112423491 11828.805575324484 11487.927977067638 11441.370735688419 10616.005198400202 11422.357607593167 9642.431111958738 11757.982410486245 1.0282002485028854 0.9606228472607041 0.9871074566391969 1.0060234113613808 0.9770322472010367 0.9730726187755256 0.9028764313282539 0.9714555787569681 0.8200753135469251 1.0 13.521352904340599 -7.092807607735659 3.1202417013451336 0.9210580196131398 0.9902260482051495 0.3171186875025612 0.047087529482763214 0.30815581605625053 5.755301146203336 0.018075404957830537 0.01383263152015875 8.075927142330319e-08 7.092807607735659 0.06916802859200966 NMQNVEHVPLSLDR ddPTM_A459_Selumetinib_30min_R2 2 NMQNVEHVPLSLDR 14 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 ; 116.79 0.0036531 10407900.0 54948.0 47692.0 59689.0 61289.0 64973.0 41897.0 43631.0 52041.0 36125.0 59467.0 False True 51894.21013427209 51349.82304604994 55848.674724469405 52941.33247057783 56810.51087401022 47667.93144690127 45659.92795318633 52192.43069414864 43351.009416834895 57750.03319617854 0.8986005247475088 0.8891739139198951 0.9670760627054504 0.9167325028322423 0.9837312245522573 0.8254182518817248 0.7906476486009666 0.9037645141579302 0.7506663982264782 1.0 15.817534155375952 -6.776532891920144 24.990112264614183 0.8441188985942647 0.9299402922985835 0.2337500448233133 0.0684761583201062 310.3572031565522 513850.79733174574 0.02262242329011173 0.02002712048602264 1.6728889329400026e-07 6.776532891920144 0.08582139370431885 NMS(ph)PDEIK ddPTM_A459_Selumetinib_30min_R2 2 NMSPDEIK 8 0 J3KS14;F5H478;J3KRU5;X6R3T8;J3QLH3;J3QQJ0;Q9UHR5-2;Q9UHR5 J3KS14 SAP30BP SAP30-binding protein 1 NMS(1)PDEIK;NMS(1)PDEIK 133.42 0.0030655 26112000.0 207415.0 159860.0 166711.0 178503.0 181702.0 173667.0 207176.0 203388.0 162554.0 160887.0 True False 195887.70464803153 172120.74796908358 155984.99576121266 154190.58346514945 158874.97032351012 197588.05285793758 216810.0945114557 203979.82540730396 195069.3421382471 156241.77427537233 1.2537473128203487 1.1016307819554387 0.9983565309895476 0.986871687679329 1.0168533419461612 1.2646301142848868 1.3876576576078379 1.305539612266528 1.2485095170158662 1.0 17.253420712054663 -6.770611189224405 24.7574148514566 1.2695130580833134 1.0644021091723561 0.3291399165695762 0.11757116979009148 174.1037062242691 469954.1510172955 0.041302977345096914 0.03693643832165878 1.6958553692890096e-07 6.770611189224405 -0.20511094891095727 NMS(ph)PDEIKIPPEPPGR ddPTM_A459_Selumetinib_30min_R1 2 NMSPDEIKIPPEPPGR 16 1 J3KS14;F5H478;J3KRU5;X6R3T8;J3QLH3;J3QQJ0;Q9UHR5-2;Q9UHR5 J3KS14 SAP30BP SAP30-binding protein 1 NMS(1)PDEIKIPPEPPGR;NMS(1)PDEIKIPPEPPGR 61.56100000000001 0.037751 15732400.0 2295.19 3075.7 3396.2 3077.0 2458.69 2863.3 2574.11 2442.7 1882.74 2432.76 True False 2348.663461337693 2715.595614145862 2935.0146939912474 2539.659712443564 2236.3019236169766 2834.497801668391 2379.942810272149 2377.911660992165 3194.872270111027 2745.0284430891024 0.8556062387079085 0.9892777690455846 1.069211031812969 0.925185208494806 0.8146734979184284 1.0325932355289567 0.8670011475705853 0.8662612101447645 1.1638758345671987 1.0 11.422605382705312 -8.257652546603078 24.998869607649787 1.0819379176106105 0.9319123301546234 0.3398585654683358 0.08593158788224078 356.8491064044505 2355787.4451767206 0.06367920313345338 0.022015881121525974 5.5251930060414924e-09 8.257652546603078 -0.15002558745598715 NMS(ph)PDEIKIPPEPPGR ddPTM_A459_Selumetinib_30min_R2 3 NMSPDEIKIPPEPPGR 16 1 J3KS14;F5H478;J3KRU5;X6R3T8;J3QLH3;J3QQJ0;Q9UHR5-2;Q9UHR5 J3KS14 SAP30BP SAP30-binding protein 1 NMS(1)PDEIKIPPEPPGR;NMS(1)PDEIKIPPEPPGR;NMS(1)PDEIKIPPEPPGR 161.48 0.00022056 21700100.0 144069.2 165800.6 155407.2 151314.2 162943.3 120966.0 120872.8 116946.2 93544.5 145235.2 True False 136062.41061870268 178516.97288704463 145408.46994656566 130704.94492844585 142472.90592241555 137627.96847998316 126493.62470490935 117286.49408051441 112256.01385171224 141041.8824096326 0.9646950841419721 1.2657018598813923 1.0309595097734943 0.9267101565536054 1.0101460891497942 0.9757950342740441 0.8968515064024013 0.8315720981366043 0.7959055277331266 1.0 17.105764109205552 -6.235508959554936 0.7245292357480774 0.8693953785516065 1.1197137299452957 0.3998114937923788 0.09501745630948608 0.7218994447274525 0.8090692777961682 0.056871415630705885 0.10555315944320101 5.814214373804414e-07 6.235508959554936 0.2503183513936892 NMS(ph)PDLR ddPTM_A459_Selumetinib_30min_R1 2 NMSPDLR 7 0 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 NMS(1)PDLR;NMS(1)PDLR 107.45 0.016687999999999998 12014700.0 10361.8 12611.8 10105.099999999999 11469.5 11504.900000000001 10199.7 12432.0 11313.4 6337.4 11073.0 True False 10603.209779446976 11135.20459293325 8732.882923341069 9466.56713417987 10464.283826355068 10097.100278586631 11494.244230939385 11013.331880897678 10754.104934617439 12494.327410153744 0.8486419021507379 0.8912208098439954 0.69894782141247 0.7576692064661832 0.8375227799658167 0.80813475964949 0.919957021583921 0.8814665663353348 0.8607189952360235 1.0 13.608985620457634 -7.254909970693756 23.176218572290516 0.905657861883282 0.8050805533977283 0.43889474144035556 0.05966672461529361 207.2801345273054 735745.6855936899 0.024189367331489783 0.018242629105053202 5.560195082452816e-08 7.254909970693756 -0.10057730848555368 NMS(ph)PDLR ddPTM_A459_Selumetinib_30min_R2 2 NMSPDLR 7 0 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 NMS(1)PDLR;NMS(1)PDLR 98.04 0.022113 33140000.0 216578.0 187177.0 219198.0 221051.0 232881.0 150127.0 191587.0 193232.0 148276.0 180001.0 True False 204541.4617904269 201532.87403108526 205095.0393247368 190943.472465756 203624.40679744503 170805.63153278155 200496.17512243855 193794.2731287202 177935.34317759465 174803.9034312367 1.170119532661856 1.1529083165489096 1.17328638147612 1.0923295688352188 1.1648733397852615 0.9771271017410206 1.1469776771964852 1.1086381329290729 1.017914014989887 1.0 17.415377875511084 -1.5228787452807435 0.0921279680880122 0.9245391480238192 1.6455271982897366 0.4812358491892865 0.051672784605760004 132.2454527310596 0.8767954215187514 0.8718063018180658 12.042670789218686 0.02999999999997196 1.5228787452807435 0.7209880502659174 NMSVIAHVDHGK ddPTM_A459_Selumetinib_30min_R2 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 ; 98.902 0.0083805 11271400.0 116996.0 108016.0 132329.0 153995.0 170281.0 106825.0 113247.0 122741.0 102635.0 149397.0 False True 110493.830692096 116300.4798738179 123815.09620892126 133020.61534380805 148888.77844854532 121539.1740892005 118513.20989467349 123098.1559891336 123164.86786150456 145083.5204299774 0.7615877417685378 0.8016105449408967 0.8534056510482798 0.9168554426414588 1.026228051313412 0.837718672175864 0.8168619671168807 0.8484640820977684 0.8489238991202204 1.0 17.14652413206229 -12.723552616975127 0.01645807195468423 1.9538807854678995 1.95509812708962e-06 0.2652713649840903 0.06908994875992594 6384.979443082682 10.924254218406134 775.4351491583303 539.895783358446 1.8899372418507903e-13 12.723552616975127 -1.9538788303697723 NMTVEQLLTGS(ph)PTSPTVEPEKPTR ddPTM_A459_Selumetinib_30min_R2 4 NMTVEQLLTGSPTSPTVEPEKPTR 24 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 NMT(0.001)VEQLLT(0.03)GS(0.962)PT(0.004)S(0.001)PT(0.001)VEPEKPTR;NMTVEQLLTGS(0.99)PT(0.009)S(0.001)PTVEPEKPTR;NMTVEQLLT(0.008)GS(0.973)PT(0.018)SPTVEPEKPTR;NMTVEQLLT(0.009)GS(0.977)PT(0.013)S(0.001)PTVEPEKPTR 133.99 5.2986e-08 15104400.0 79909.0 74461.0 87052.0 92042.0 89318.0 72792.0 76123.0 74142.0 58176.0 85539.0 True False 75467.97768107199 80171.91927014844 81451.16909505133 79505.72081869376 78097.07432694877 82818.43726001475 79662.87033486282 74357.7409451312 69812.82557325359 83069.26681298715 0.9084945681652897 0.9651213059414444 0.9805211026891736 0.9571015114131686 0.9401440186389003 0.9969804771054849 0.9589933003045145 0.8951293757356965 0.840417018852741 1.0 16.342027200498435 -7.757370167197348 24.53746618865571 0.900829888741294 0.9600745191697015 0.18308179510735922 0.04288383000803228 100.710397944302 607301.3195276172 0.020031923570617987 0.011019046629290225 1.7483558571638688e-08 7.757370167197348 0.05924463042840755 NMTVEQLLTGSPT(ph)SPTVEPEKPTR ddPTM_A459_Selumetinib_30min_R1 1 NMTVEQLLTGSPTSPTVEPEKPTR 24 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 NMTVEQLLTGSPT(0.48)S(0.48)PT(0.041)VEPEKPTR 100.17 9.1357e-06 19138000.0 1209.4 1451.9 1409.8 1681.3 1189.9 1398.3 1724.1 1255.2 857.09 1243.0 True False 1237.5766669172506 1281.9108730300018 1218.3569034770796 1387.6925169097701 1082.273755093908 1384.2343715548175 1594.049748919127 1221.9080185357855 1454.419130623166 1402.5511578453074 0.8823754199586548 0.9139851091060084 0.8686719886558725 0.9894059900400609 0.7716465449692181 0.9869403791882861 1.1365359045926087 0.8712038856486076 1.0369811628529413 1.0 10.453837678543353 -6.974468077949719 24.94593166252963 1.0092031055939663 0.8904452131794951 0.3770511395839232 0.0781750756435347 238.8471989293402 233364.6065343166 0.026479573505499048 0.02335207792828029 1.0605518895044754e-07 6.974468077949719 -0.11875789241447121 NMTVEQLLTGSPT(ph)SPTVEPEKPTR ddPTM_A459_Selumetinib_30min_R2 4 NMTVEQLLTGSPTSPTVEPEKPTR 24 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 NMTVEQLLT(0.011)GS(0.011)PT(0.43)S(0.43)PT(0.118)VEPEKPTR;NMTVEQLLTGSPT(0.836)S(0.16)PT(0.004)VEPEKPTR;NMTVEQLLTGSPT(0.637)S(0.363)PT(0.001)VEPEKPTR;NMTVEQLLTGSPT(0.633)S(0.365)PT(0.001)VEPEKPTR 179.0 4.6831999999999997e-20 22326300.0 105887.0 99719.0 111018.0 114149.0 112707.0 93327.0 92924.0 91983.0 71634.0 108833.0 True False 100002.22443924558 107367.12665287823 103875.22274725883 98601.70928199161 98547.73904663585 106181.94711184461 97245.15012541287 92250.65530139454 85962.8016211917 105690.70850790675 0.9461780117763557 1.015861547042672 0.9828226550254217 0.9329269400688632 0.9324162969279695 1.0046478882663665 0.920091761123334 0.8728360004748501 0.8133430349249745 1.0 16.689489026381914 -7.5047297560568555 4.736519490582006 0.8838315868358888 0.968501772600694 0.3013893649006666 0.05044042340556084 0.2074137173591944 12.313118631891362 0.022629288939727026 0.013883738036307271 3.1280252056004515e-08 7.5047297560568555 0.08467018576480523 NMTVEQLLTGSPTS(ph)PTVEPEKPTR ddPTM_A459_Selumetinib_30min_R1 2 NMTVEQLLTGSPTSPTVEPEKPTR 24 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 NMTVEQLLT(0.06)GS(0.046)PT(0.254)S(0.631)PT(0.009)VEPEKPTR;NMTVEQLLT(0.213)GS(0.009)PT(0.154)S(0.616)PT(0.007)VEPEKPTR 105.55 1.1594e-06 41199000.0 3678.8 4060.6 4949.799999999999 5658.200000000001 4258.3 4011.0 4230.2 4512.5 2343.0 3488.3 True False 3764.508882301294 3585.183064278276 4277.644347305187 4670.101587568469 3873.1375168639265 3970.6529816966154 3911.1126082464434 4392.813841334238 3975.8998740506595 3936.0572839193815 0.9564161826813491 0.9108564245051541 1.0867840681032126 1.1864922816667325 0.9840145194754885 1.008789429442141 0.99366252219579 1.1160441844383002 1.0101224619606157 1.0 11.942535501941128 -5.2577947827012235 24.99763385985503 1.0516689772134433 0.9336362949440997 0.350482596400713 0.062264545481936724 338.6294913288996 2322574.4459468233 0.01666361500921324 0.04055771482128203 5.523383742398735e-06 5.2577947827012235 -0.1180326822693436 NMTVEQLLTGSPTS(ph)PTVEPEKPTR ddPTM_A459_Selumetinib_30min_R2 1 NMTVEQLLTGSPTSPTVEPEKPTR 24 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 NMTVEQLLTGSPT(0.263)S(0.736)PT(0.001)VEPEKPTR 127.14 7.4283e-08 6104500.0 21796.0 23730.0 24959.0 26299.0 26057.0 18099.0 23438.0 22110.0 17535.0 25205.0 True False 20584.665576301126 25550.014696023783 23353.165113304494 22717.030831694523 22783.48670746441 20591.972963636206 24527.91344151594 22174.336439492454 21042.489968836 24477.26615954528 0.8409707784410321 1.0438263215134493 0.9540757109509787 0.9280869310985399 0.9308019351082492 0.8412693161652799 1.002069155993179 0.9059155665080365 0.859674844064649 1.0 14.579154813465859 -5.85033967448824 3.7748960720993807 0.9192950598080478 0.9560667959082639 0.015229423705468426 0.06653589120886481 0.7403009820861455 20.243984509478032 0.01851243960508975 0.029252921913205308 1.4114331893926582e-06 5.85033967448824 0.03677173610021611 NNASTDYDLSDK ddPTM_A459_Selumetinib_30min_R1 1 NNASTDYDLSDK 12 0 P39023;B5MCW2;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 186.58 4.4284e-12 0.0 1324.5 1437.8 1824.1 1777.5 1407.6 1590.8 1401.4 1330.5 998.96 1198.0 False True 1355.3582729716372 1269.4617075849144 1576.3972390640815 1467.0929928074213 1280.2828285319638 1574.7979963308337 1295.6912697263867 1295.2108179269144 1695.1621588483329 1351.7749695081893 1.002650813592703 0.939107274672187 1.1661683894306873 1.0853085949218217 0.9471123947484867 1.1649853206734446 0.9585110680054926 0.9581556450909471 1.254026888414036 1.0 10.400639290279655 -5.222375508259133 24.933192662200437 1.061317129485774 0.9708790244556164 0.12703367199298465 0.09974282921683486 1135.8099428276182 724946.4604919051 0.024568791512062774 0.06500110890471904 5.992726972052653e-06 5.222375508259133 -0.09043810503015759 NNASTDYDLSDK ddPTM_A459_Selumetinib_30min_R2 1 NNASTDYDLSDK 12 0 P39023;B5MCW2;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 155.88 0.005958 10823000.0 23246.0 22635.0 22910.0 22829.0 25924.0 17364.0 19240.0 21166.0 20199.0 23242.0 False True 21954.080381111027 24371.031717003716 21435.995542521963 19719.650817778427 22667.195356499506 19755.733385301904 20134.698123336726 21227.589555780065 24239.364407215187 22570.94307003181 0.9726700525092452 1.0797524782808894 0.9497164330268169 0.873674208321444 1.0042644335316007 0.875272837470945 0.8920627756165949 0.9404830577932137 1.0739189909790963 1.0 14.462179078718714 -5.370842259079042 7.984382357549581 0.9429960780176799 1.0258565316893289 0.1687895422587501 0.06471768850235884 0.4074702612505963 26.425237967851547 0.016814326776605708 0.03515630194804073 4.2575302361558315e-06 5.370842259079042 0.08286045367164896 NNAYLAQS(ph)PQLYK ddPTM_A459_Selumetinib_30min_R1 2 NNAYLAQSPQLYK 13 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 NNAYLAQS(1)PQLYK;NNAY(0.041)LAQS(0.953)PQLY(0.007)K 159.41 0.0003643 22633000.0 3905.3999999999996 4725.5 4668.299999999999 5106.9 3820.2 4386.4 3663.8 3904.7999999999997 2348.8 3151.4 True False 3996.388221414446 4172.236263174652 4034.370501136369 4215.075783385775 3474.663584511088 4342.276798532543 3387.4366162576994 3801.232019422035 3985.7420504354177 3555.912887235483 1.123871238735943 1.17332353054867 1.1345526814277105 1.1853709348495185 0.9771509299296807 1.221142625321289 0.9526208103740235 1.068989072557757 1.1208773040371363 1.0 11.796004266115267 -6.237088043912029 24.95589322942029 1.063254724158763 1.1542308153356486 0.29242544937105 0.07387821050024057 1038.1360133393723 1063908.9080511339 0.020748228885618086 0.026774208567601848 5.793112415649541e-07 6.237088043912029 0.09097609117688554 NNAYLAQS(ph)PQLYK ddPTM_A459_Selumetinib_30min_R2 2 NNAYLAQSPQLYK 13 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 NNAY(0.001)LAQS(0.999)PQLYK;NNAYLAQS(1)PQLYK 142.57 0.00076849 11313900.0 40257.0 37062.0 41066.0 43305.0 43794.0 31523.0 36736.0 39395.0 28997.0 35779.0 True False 38019.67710153947 39904.53622688718 38423.858269280114 37406.784294708224 38292.20619667254 35865.007112697065 38444.29679100302 39509.63292780665 34797.2102438744 34745.96730499387 1.094218410090862 1.1484652557406827 1.1058508727646685 1.076579160003179 1.102061884205163 1.0322063218986095 1.1064390999262124 1.1370998130804122 1.001474788093557 1.0 15.084557924674924 -7.928767331614607 0.012877913767149387 1.258865473247113e-07 2.1373810893641054 0.4177498692865118 0.03804895411186991 593.1464013259947 7.832489015346405 648.8705885909256 649.3656241912564 1.178237031705975e-08 7.928767331614607 2.137380963477558 NNCPDKTSAAAGSSS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 NNCPDKTSAAAGSSSR 16 1 A0A087X2H1;Q9ULT8;H0YJP0 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 NNCPDKTSAAAGS(0.002)S(0.078)S(0.92)R 78.40100000000002 0.014453 3427400.0 670.11 531.25 1418.5 1298.9 1064.6 658.43 956.92 1161.4 874.67 487.32 True False 685.7222591929215 469.0510030285753 1225.8754912627594 1072.0714983727482 968.3071179703959 651.8067920066072 884.7387539792879 1130.5958992411267 1484.2511066307673 549.8722688987739 1.2470573585502205 0.8530181090381974 2.2293822776657084 1.949673695165206 1.7609673604919542 1.1853785485708837 1.608989585437995 2.05610641450489 2.699265248642687 1.0 9.102952720361627 -5.251738219997273 24.948302694336 1.8225144674537888 1.0500376802727929 0.2948657255993543 0.470579950370788 829.5877841583234 2133425.3497353634 0.12219974740422793 0.3147316628434544 5.600951087037772e-06 5.251738219997273 -0.7724767871809959 NNCPFS(ph)ADENYRPLAK ddPTM_A459_Selumetinib_30min_R1 2 NNCPFSADENYRPLAK 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 NNCPFS(1)ADENYRPLAK;NNCPFS(1)ADENYRPLAK 98.443 0.0038954 22149300.0 3762.3 4800.3 4559.9 5229.1 4500.7 4361.1 4714.0 4865.700000000001 2884.9 3957.6 True False 3849.9542698385744 4238.278644401073 3940.6906257377923 4315.935847363874 4093.6124796631207 4317.23129356198 4358.419184736827 4736.645829978946 4895.464595240608 4465.5965102884875 0.862136617351902 0.9490957444624281 0.8824555950495435 0.9664858518722407 0.9167000355342593 0.9667759466434815 0.9759993261136044 1.0606972257941298 1.0962621866892202 1.0 12.12463718676213 -7.391633894569564 1.3676325152515174 1.0605988208666373 0.9174824348523356 0.7005078158067793 0.03777614189207396 0.23001059431786705 0.8273195979208386 0.023992947129631598 0.012520781540140932 4.0585051876911375e-08 7.391633894569564 -0.14311638601430166 NNCPFS(ph)ADENYRPLAK ddPTM_A459_Selumetinib_30min_R2 2 NNCPFSADENYRPLAK 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 NNCPFS(1)ADENYRPLAK;NNCPFS(1)ADENYRPLAK 79.462 0.013551 35309000.0 90239.0 81588.0 95430.0 97189.0 89033.0 71641.0 76817.0 77201.0 53729.0 81784.0 True False 85223.8776353385 87845.53725323151 89290.13769632776 83951.69053962358 77847.87857488116 81508.89745775238 80389.14270999786 77425.64212868645 64476.30131369202 79422.68341964892 1.0730420324007133 1.1060509853221454 1.1242397492985947 1.0570241009869252 0.9801718504467182 1.0262672318319999 1.0121685549862678 0.9748555298690851 0.8118121742754009 1.0 16.27726348494494 -6.796158212550897 0.6734540061571783 0.9254580339905703 1.106563981731627 0.5727924439125702 0.05460838530863013 0.5517925006706532 0.5466332367660173 0.04268551321271727 0.04305268524011252 1.598975419174077e-07 6.796158212550897 0.18110594774105682 NNDQPQSANANEPQDS(ph)TVNLQSPLK ddPTM_A459_Selumetinib_30min_R1 1 NNDQPQSANANEPQDSTVNLQSPLK 25 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 NNDQPQSANANEPQDS(0.564)T(0.09)VNLQS(0.347)PLK 75.275 0.002855 0.0 627.31 754.12 786.43 600.03 373.33 587.44 633.96 642.49 387.62 683.1 True False 641.9251024672241 665.8272798191235 679.6371255507734 495.24602445808 339.56236741676474 581.5308869528442 586.1398867958761 625.449078098357 657.7628293553204 770.7825389574662 0.8328225796804761 0.8638328531931957 0.8817495093622996 0.642523668385032 0.44054237123228696 0.754468163925201 0.7604478009954256 0.8114468692354108 0.8533701739598145 1.0 9.590180079461286 -8.471597563700046 1.2224285536079775 0.9957969000992988 0.7347795383210428 0.30985933324292125 0.12036915131541603 0.6607780763613205 2.158648875601722 0.1295835757292696 0.04053017324069875 3.3759999871452037e-09 8.471597563700046 -0.26101736177825596 NNDQPQSANANEPQDSTVNLQS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 NNDQPQSANANEPQDSTVNLQSPLK 25 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 NNDQPQSANANEPQDSTVNLQS(1)PLK;NNDQPQSANANEPQDSTVNLQS(1)PLK 184.0 2.7056e-21 12063100.0 120501.0 120751.0 120410.0 120201.0 113668.0 85103.0 105329.0 94992.0 71353.0 112640.0 True False 113804.0368237227 130012.21342433922 112662.95169249522 103829.41644170955 99388.00963518686 96825.16576188365 110227.007205454 95268.41099322791 85625.59376939591 109387.79052613271 1.040372387780654 1.1885441034964441 1.0299408293248238 0.9491865220269233 0.9085841222055133 0.8851551466226218 1.0076719410391675 0.8709236244283435 0.7827710328324072 1.0 16.73909219309379 -5.676682828163836 2.4100689364596057 0.9081293702221839 1.1153137094863739 0.5790452499474608 0.06950591856256456 0.19449241153481317 2.28647204652764 0.020199006791324227 0.04029649502368105 2.1053154221886294e-06 5.676682828163836 0.20718433926419 NNKEY(ph)LEFRR ddPTM_A459_Selumetinib_30min_R1 1 NNKEYLEFRR 10 2 C9JDV8;H7C2U6;Q9BPW8 C9JDV8 NIPSNAP1 Protein NipSnap homolog 1 1 NNKEY(1)LEFRR 83.99799999999998 0.025467 0.0 1225.4 1586.4 1785.0 1839.9 1339.7 1437.8 1486.0 1477.3 866.59 1336.6 True False 1253.94943578667 1400.6635505026481 1542.6068043031553 1518.596004200491 1218.5243715432457 1423.3370374179485 1373.9098236145355 1438.1172050533123 1470.539936770619 1508.165629586516 0.8314401357432188 0.9287199781145119 1.0228364670570578 1.0069159344367467 0.8079512937032789 0.9437537956677714 0.910980728284606 0.953553891456598 0.9750520154565434 1.0 10.558579161452668 -8.237458760829005 1.8877519097623858 0.9971756329834589 0.9257442394417766 0.1496661963753193 0.06289626269182952 0.7434286478473447 4.847700013548896 0.06141998369909611 0.018225691454152648 5.788169482872055e-09 8.237458760829005 -0.07143139354168226 NNLAGAEELFAR ddPTM_A459_Selumetinib_30min_R2 1 NNLAGAEELFAR 12 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 124.39 0.042453 3007400.0 38805.0 34959.0 36061.0 36110.0 39080.0 26749.0 29910.0 31620.0 21468.0 30981.0 False True 36648.37344872294 37640.242889098 33740.87452024814 31191.75570677552 34170.421020367256 30433.431946754255 31300.874265540613 31712.008965027217 25762.1998660377 30086.498031695006 1.2181003389000356 1.251067600138953 1.1214623411705604 1.0367360027716142 1.1357393932776751 1.011531216251681 1.040362830947168 1.0540279208174974 0.8562711366041399 1.0 14.87682857108845 -4.826474594296432 0.34736524378552747 0.9595874836782285 1.470121705988164 0.6913330275559999 0.060316387467009916 3.6419930325223038 0.3613832347741947 0.05817548812772122 0.7864023683526058 1.4911639841965032e-05 4.826474594296432 0.5105342223099354 NNLSAS(ph)MFDLSMK ddPTM_A459_Selumetinib_30min_R2 2 NNLSASMFDLSMK 13 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 NNLSAS(1)MFDLSMK;NNLS(0.001)AS(0.999)MFDLSMK 137.19 0.0010539999999999998 6135300.0 40248.0 27921.0 34164.0 40293.0 29856.0 38360.0 33658.0 25736.0 23125.0 33067.0 True False 38011.17728550961 30062.450919834777 31965.92543495072 34805.02389069803 26105.222363973513 43643.74180259046 35223.16369206175 25810.887499175853 27750.64616648603 32112.269791616112 1.1836963731362766 0.9361671135337651 0.9954427277294613 1.0838543683319746 0.8129360687792015 1.3590986275901615 1.096875553196113 0.8037702618553165 0.8641757915764392 1.0 14.970837022233058 -7.754607676948702 24.99597761041983 0.875479761586883 1.061219682871668 0.2393084844852691 0.14418770550889431 218.12119386797977 798074.7981616092 0.06980944522347986 0.03914659110934404 1.759512364425766e-08 7.754607676948702 0.185739921284785 NNLSASMFDLS(ph)MK ddPTM_A459_Selumetinib_30min_R1 1 NNLSASMFDLSMK 13 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 NNLSAS(0.027)MFDLS(0.973)MK 113.37 0.004592100000000001 15399000.0 3680.9 3313.6 3472.8 3272.1 2656.6 3351.2 3068.1 2642.4 2259.3 2775.4 True False 3766.6578082154037 2925.642171549151 3001.21283472493 2700.6891599241417 2416.3109990608245 3317.4899706461447 2836.6707468585178 2572.314968275146 3833.8670872567873 3131.6496246853335 1.2027711460837116 0.9342175920600051 0.9583488558451012 0.8623854784506761 0.771577695031453 1.059342636703646 0.905807190082302 0.8213929642699447 1.2242324483033482 1.0 11.612707094671247 -10.297571429365293 15.981203864418372 0.9999999997365875 0.9568616155873548 0.0 0.14394101719404193 0.0 0.0 0.1354660234599154 0.03285533667103714 5.039977186760333e-11 10.297571429365293 -0.043138384149232656 NNMT(ph)ASMFDLSMKDK ddPTM_A459_Selumetinib_30min_R1 1 NNMTASMFDLSMKDK 15 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3;Q7L804;Q7L804-2 Q6WKZ4;Q7L804 RAB11FIP1;RAB11FIP2 Rab11 family-interacting protein 1;Rab11 family-interacting protein 2 1 NNMT(0.64)AS(0.312)MFDLS(0.048)MKDK 107.11 0.0059813 27199000.0 2881.6 1751.6 3061.6 2941.2 2094.3 2493.1 2008.7 2184.8 2107.3 1814.6 True False 2948.7356733824618 1546.5218577032513 2645.851536165007 2427.5746331618493 1904.8709347786973 2468.021677553684 1857.1821417863532 2126.852006769428 3575.934188897548 2047.5215857008004 1.4401487603234253 0.7553140677508056 1.2922215592952675 1.1856161371461045 0.9303300869117439 1.2053702851239834 0.9070391026674817 1.0387446079311908 1.74646959224785 1.0 10.999662946012789 NNMTAS(ph)MFDLSMK ddPTM_A459_Selumetinib_30min_R1 1 NNMTASMFDLSMK 13 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3;Q7L804;Q7L804-2 Q6WKZ4;Q7L804 RAB11FIP1;RAB11FIP2 Rab11 family-interacting protein 1;Rab11 family-interacting protein 2 1 NNMT(0.005)AS(0.656)MFDLS(0.339)MK 119.77 0.0031637 33656000.0 2777.8 2488.6 2362.8 2125.8 1919.7 2442.3 2031.9 2391.4 1812.5 2568.5 True False 2842.517335342103 2197.233555081248 2041.944737931369 1754.5689362081666 1746.063473950562 2417.7326794309747 1878.6321471079252 2327.9723036380506 3075.6801202376537 2898.1919943086687 0.9807898651725293 0.7581394053244473 0.7045581320841555 0.605401208634109 0.6024664609450989 0.8342210192350276 0.6482083142859733 0.8032498565345607 1.0612409827497722 1.0 11.500937455837828 -8.151501835423296 3.967685124890824 1.0300912610673756 0.7270814584822198 0.5379566952807597 0.10809828119498617 0.1795875942622055 4.743803807392942 0.08580412448812103 0.02904713985331297 7.055018624394553e-09 8.151501835423296 -0.30300980258515575 NNMTAS(ph)MFDLSMK ddPTM_A459_Selumetinib_30min_R2 1 NNMTASMFDLSMK 13 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3;Q7L804;Q7L804-2 Q6WKZ4;Q7L804 RAB11FIP1;RAB11FIP2 Rab11 family-interacting protein 1;Rab11 family-interacting protein 2 1 NNMT(0.136)AS(0.85)MFDLS(0.015)MK 96.247 0.014339 10844000.0 103040.0 74511.0 65641.0 83122.0 60097.0 79910.0 77278.0 68494.0 62449.0 81309.0 True False 97313.44930180158 80225.7541093731 61417.72952451709 71800.64020655211 52547.07758600335 90916.87714924422 80871.58012345205 68693.30620020788 74940.54497084908 78961.39790384706 1.232418015449805 1.0160123331031408 0.7778196834775739 0.9093131848296968 0.6654780561254883 1.151409164006387 1.0241913424827036 0.8699606139680702 0.9490782453231862 1.0 16.26885991051772 -4.848925431889294 3.5340283583598473 0.9154615877982557 1.2482760538385675 0.3596301053613755 0.12663729627792844 0.2825789915012168 5.895212855708411 0.03279191790415755 0.22374058462227042 1.416036891798601e-05 4.848925431889294 0.33281446604031184 NNMTAS(ph)MFDLSMKDK ddPTM_A459_Selumetinib_30min_R1 1 NNMTASMFDLSMKDK 15 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3;Q7L804;Q7L804-2 Q6WKZ4;Q7L804 RAB11FIP1;RAB11FIP2 Rab11 family-interacting protein 1;Rab11 family-interacting protein 2 1 NNMT(0.09)AS(0.91)MFDLSMKDK 101.61 0.0037554 34335000.0 2664.3 1536.3 2679.8 2530.4 1605.7 1947.2 1370.1 2053.8 1756.3 1373.6 True False 2726.373006174659 1356.4292817935068 2315.8978790877286 2088.5131414907996 1460.4647185093609 1927.6129359161419 1266.752253926162 1999.3265523173973 2980.312824923249 1549.914939997035 1.759046858519781 0.8751636923998563 1.4942096623006673 1.347501780642746 0.9422870125454464 1.2436894994507437 0.8173043702182684 1.2899588878865973 1.9228879908267422 1.0 10.59797332660564 -4.7354517671377785 24.7638929808538 1.2166862767202444 1.75904983503061 0.21091032319380076 0.31580728646657646 3913.3023370156693 3728810.963890294 0.07787826844492804 6.053514123711582 1.838858166607491e-05 4.7354517671377785 0.5423635583103656 NNNS(ph)LVPKY(ph)HPNFWMDGK ddPTM_A459_Selumetinib_30min_R1 1 NNNSLVPKYHPNFWMDGK 18 1 Q08881 Q08881 ITK Tyrosine-protein kinase ITK/TSK 2 NNNS(1)LVPKY(1)HPNFWMDGK 72.446 0.045547 0.0 602.7 867.62 887.11 1097.9 955.15 992.17 801.71 813.81 426.56 602.42 True False 616.7417373499479 766.0386470544046 766.6453345464271 906.1723751354533 868.7568511454294 982.1896706182822 741.2363692395761 792.2251151725684 723.8411652902477 679.7464750677153 0.9073114167874266 1.126947582888301 1.1278401031355918 1.3331034560277517 1.2780601047749238 1.4449352907941715 1.0904600412466063 1.1654714577131835 1.0648693179587871 1.0 9.408852954722057 -8.28296273974713 1.562622299637696 1.0034678430812742 1.2012759660567855 0.17014810462292673 0.1382181441424804 0.6916286241468391 3.2607237433484833 0.13901656243288474 0.04202339606232435 5.212394288729199e-09 8.28296273974713 0.1978081229755113 NNPNESVTANAATNS(ph)PSCTR ddPTM_A459_Selumetinib_30min_R2 1 NNPNESVTANAATNSPSCTR 20 0 Q5HYY5;Q96T21-2;Q96T21-3;Q96T21 Q5HYY5 SECISBP2 Selenocysteine insertion sequence-binding protein 2 1 NNPNESVTANAAT(0.002)NS(0.715)PS(0.142)CT(0.142)R 110.34 0.00097218 0.0 6143.6 7549.7 7825.1 7683.2 7012.9 7229.8 6255.8 5084.1 4569.1 6953.2 True False 5802.16330677939 8128.737713888358 7321.641585324692 6636.7349057407255 6131.876805878539 8225.639324410024 6546.707095632537 5098.893889281939 5483.047671320702 6752.4430494167955 0.8592687512233842 1.2038217359849384 1.084295199788032 0.9828642547846348 0.9080975227785365 1.2181723361769734 0.9695316269565535 0.7551183848521799 0.8120094654917925 1.0 12.721193851655427 -7.554767594254 7.6055462078013125 0.8412899129141332 1.047307238701456 0.3197323940592285 0.12142856719272486 0.22008056269746334 41.80842424650069 0.05579642663373572 0.032342949114538944 2.787612515812389e-08 7.554767594254 0.20601732578732268 NNPS(ph)PPPDSDLER ddPTM_A459_Selumetinib_30min_R1 1 NNPSPPPDSDLER 13 0 E7ESD5;E9PLN6;F2Z2Y1;O95677-3;O95677-5;O95677-2;O95677-4;O95677 E7ESD5 EYA4 Eyes absent homolog;Eyes absent homolog 4 1 NNPS(0.781)PPPDS(0.219)DLER 126.07 0.0020652 12500000.0 3012.9 3619.6 3429.0 3508.8 3126.0 3154.7 2776.0 2404.4 1769.2 2595.7 True False 3083.0947079171356 3195.815549293614 2963.3606341487484 2896.053948333434 2843.2538519401237 3122.966582238421 2566.6040850295776 2340.6275014080975 3002.2031827445257 2928.883379259105 1.052651918389813 1.0911378622736534 1.011771467288112 0.9887911443800895 0.9707637634446742 1.066265254654288 0.8763080507762757 0.7991535333851997 1.0250333639108458 1.0 11.51613503454918 -6.145649832635773 0.7074385783796501 0.9246572587830694 1.0762846776347077 0.27849780350856 0.07180364397900336 1.0222015180778679 1.0595147752555654 0.043979988539247596 0.0930001355282432 7.15072649738351e-07 6.145649832635773 0.15162741885163833 NNPS(ph)PPPDSDLER ddPTM_A459_Selumetinib_30min_R2 2 NNPSPPPDSDLER 13 0 E7ESD5;E9PLN6;F2Z2Y1;O95677-3;O95677-5;O95677-2;O95677-4;O95677 E7ESD5 EYA4 Eyes absent homolog;Eyes absent homolog 4 1 NNPS(0.999)PPPDS(0.001)DLER;NNPS(0.999)PPPDS(0.001)DLER 170.35 0.00023012 39024000.0 72999.0 57590.0 83330.0 72836.0 86807.0 61417.0 58164.0 71057.0 59998.0 63265.0 True False 68942.00781815032 62006.96781896369 77968.63852284402 62915.611150891826 75901.5285955736 69876.63426198391 60868.74124977948 71263.76410588044 71999.27648418714 61438.3750677894 1.1221326693956606 1.0092546840724046 1.269054372561377 1.0240441919479883 1.235409115423804 1.137345090668234 0.9907283710322514 1.1599226709243202 1.1718942176570448 1.0 15.906852439478266 -10.486993580830651 8.321824744745644 0.9999999955567312 1.1230916074974646 0.15115427304281026 0.08840357274322645 4.654918876140774e-10 7.332541565923627e-11 0.08189983250408552 0.019863627066749365 3.2584151712680124e-11 10.486993580830651 0.12309161194073337 NNQTVLEQSIET(ph)T(ph)NHVVS(ph)IT(ph) ddPTM_A459_Selumetinib_30min_R1 1 NNQTVLEQSIETTNHVVSIT 20 0 H0YKA3 H0YKA3 ZHX2 4 NNQT(0.07)VLEQS(0.142)IET(0.792)T(0.998)NHVVS(0.999)IT(0.999) 53.481 0.022437 14961000.0 2032.6 2327.2 2074.6 2848.0 2404.4 2043.3 2183.9 2449.5 1203.5 1925.6 True False 2079.9556252488883 2054.730342114071 1792.880714962086 2350.6502635811744 2186.922444531298 2022.7462571679623 2019.1666647320228 2384.531302902652 2042.2515998378005 2172.769516932362 0.9572831398083522 0.9456734025866925 0.8251591809394379 1.0818682079542217 1.0065137730848313 0.9309529802423725 0.929305501111225 1.0974616885592483 0.9399301600664787 1.0 11.085319429078003 -5.7625756353281306 24.999982759985812 0.9967637773129853 0.9130020741717171 0.28959878069270495 0.06351751173006144 41.323980015775646 909251.8321228072 0.017860185004444952 0.028259708960860178 1.727525094101791e-06 5.7625756353281306 -0.08376170314126818 NNS(ph)FTAPSTVGK ddPTM_A459_Selumetinib_30min_R1 1 NNSFTAPSTVGK 12 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 NNS(0.921)FT(0.079)APSTVGK 173.06 0.00019926 7560800.0 2593.4 2662.7 2647.2 2932.2 2317.1 2433.2 2633.4 2408.9 1535.8 2309.0 True False 2653.8211741220434 2350.949846144354 2287.7247800287464 2420.146314210926 2107.5187141172305 2408.7242171688367 2434.760517837498 2345.008146790037 2606.1404296060628 2605.3826415646163 1.0185917153913093 0.9023434057780215 0.8780763115297697 0.9289024481860945 0.8089094785906755 0.9245184099800098 0.9345116832341163 0.9000628580920397 1.0002908547978164 1.0 11.347279555264985 -8.264852031597492 24.10595697954576 1.00014545549417 0.9088336875841628 0.33609374547333815 0.04940132357048879 208.97001192352084 1476042.954543263 0.04145500403942781 0.01241163618665547 5.434354537594854e-09 8.264852031597492 -0.09131176791000717 NNS(ph)FTAPSTVGK ddPTM_A459_Selumetinib_30min_R2 3 NNSFTAPSTVGK 12 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 NNS(0.5)FT(0.5)APSTVGK;NNS(0.906)FT(0.094)APSTVGK;NNS(0.918)FT(0.082)APSTVGK 152.88 0.00048402 27460600.0 180536.0 125787.0 185790.0 206149.0 204206.0 85405.0 126749.0 155694.0 76111.0 118436.0 True False 170502.53186286942 135434.45843104678 173836.4736728572 178071.1505731392 178551.81665519724 97168.7635206007 132643.07964837883 156147.04376347084 91335.32671902335 115016.4449463162 1.4824187266651416 1.177522557702602 1.5114053799349751 1.5482233923701407 1.5524024998211003 0.8448249601694272 1.1532531692341024 1.3576062434928526 0.7941066754554448 1.0 16.811480625574504 -6.751277303689263 24.99997086449549 1.0600145217663146 1.4473927561146254 0.5841515118227889 0.1781061573459344 167.99944151419712 413298.9214261478 0.06021450676121358 0.05955907886347333 1.7730569952817407e-07 6.751277303689263 0.38737823434831076 NNS(ph)GEEFDCAFR ddPTM_A459_Selumetinib_30min_R2 1 NNSGEEFDCAFR 12 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 NNS(1)GEEFDCAFR 98.654 0.015086000000000004 1332900.0 9515.4 9664.3 12174.0 10204.0 11922.0 8527.9 9460.4 9442.3 9297.5 7518.9 True False 8986.572161164231 10405.520734377686 11390.738094048998 8814.197597118184 10424.251775967712 9702.540816431476 9900.327345426971 9469.775529743087 11157.259793855297 7301.809820551679 1.2307321584671542 1.4250604973427683 1.5599883280975928 1.2071250571755152 1.4276257574701008 1.3287857469421755 1.3558730765024176 1.296907994383728 1.5280129266653955 1.0 12.83403837817879 -10.610328233400375 4.510346852694861 0.9999732743510719 1.372991208346543 0.5100972032564106 0.10976375853967416 74619023.38490126 0.9129155338854842 22133.679953234285 0.02541653801823075 2.45285438358789e-11 10.610328233400375 0.3730179339954711 NNS(ph)NTCNIENELEDSRK ddPTM_A459_Selumetinib_30min_R1 1 NNSNTCNIENELEDSRK 17 1 Q6PL18;A0A0B4J211 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 NNS(0.992)NT(0.008)CNIENELEDSRK 142.23 0.00025636 11123000.0 773.76 907.51 703.48 867.46 757.93 622.81 961.18 1148.3 423.12 969.71 True False 791.7871025251295 801.2583073100469 607.9512799390383 715.9743952409144 689.3753653234102 616.545096866235 888.6774187495419 1117.8433537959233 718.0037365379062 1094.1817242752804 0.7236340042597231 0.7322899748126864 0.5556218555393149 0.6543468779970095 0.6300373603662688 0.5634759594203578 0.8121844836497775 1.0216249540599072 0.6562015436818489 1.0 10.095636648878864 -7.4375424104697885 5.2810183973608344 0.886244807079491 0.6444107391824381 0.5352576046779967 0.10644468352808684 0.1707713884810152 7.885819166048354 0.044269607956327235 0.02906200421573643 3.651384683856377e-08 7.4375424104697885 -0.24183406789705297 NNS(ph)PPTVGAFGHTR ddPTM_A459_Selumetinib_30min_R1 2 NNSPPTVGAFGHTR 14 0 Q86XL3;F5H1D4;Q86XL3-3 Q86XL3 ANKLE2 Ankyrin repeat and LEM domain-containing protein 2 1 NNS(1)PPTVGAFGHTR;NNS(0.991)PPT(0.008)VGAFGHT(0.001)R 155.24 0.00021818 22528000.0 3560.4 4166.2 5633.2 5076.4 4070.3999999999996 4333.9 4389.5 3985.2 2346.1 3397.1 True False 3643.350392667586 3678.4193671861667 4868.242380952679 4189.902035829871 3702.233038687488 4290.304900866354 4058.3964809932777 3879.499550246029 3981.1603476356154 3833.1508755561517 0.9504844737265847 0.9596333373265578 1.27003672409486 1.0930699499851955 0.9658458951606832 1.1192632484741092 1.0587625201171986 1.0120915341437355 1.038613004518897 1.0 11.904315069425309 -7.719784488718068 6.719987400397017 1.0190116662822966 1.0639996357008938 0.04373340024429051 0.08976347587413931 0.724878138992982 85.01279800302632 0.04591885972345755 0.025753324818736382 1.9064065052218875e-08 7.719784488718068 0.044987969418597284 NNS(ph)PPTVGAFGHTR ddPTM_A459_Selumetinib_30min_R2 4 NNSPPTVGAFGHTR 14 0 Q86XL3;F5H1D4;Q86XL3-3 Q86XL3 ANKLE2 Ankyrin repeat and LEM domain-containing protein 2 1 NNS(1)PPTVGAFGHTR;NNS(1)PPTVGAFGHTR;NNS(0.988)PPT(0.012)VGAFGHTR;NNS(0.999)PPT(0.001)VGAFGHTR 152.13 0.00025692 37733500.0 160611.0 122717.0 131204.0 137546.0 117219.0 85307.0 129134.0 114232.0 87158.0 141242.0 True False 151684.88359677454 132128.9993026528 122762.47748411396 118811.99751991524 102492.90126884406 97057.26491015604 135138.98687416656 114564.39620787426 104592.03539799301 137163.9764692121 1.1058653117338124 0.9632922776361078 0.8950052385778513 0.8662040907408648 0.7472290021560412 0.7076002563394739 0.9852367243413939 0.8352367666563637 0.7625328317998261 1.0 17.065542109058157 -4.83539661327263 1.2423092753969658 0.8335136116567163 1.2084688662529888 0.44981905821799695 0.08978751267311044 1.2008566754041452 1.7098565660315286 0.02747028849403411 0.567571787624993 1.4608424714436029e-05 4.83539661327263 0.37495525459627244 NNS(ph)VSGLSVK ddPTM_A459_Selumetinib_30min_R2 2 NNSVSGLSVK 10 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 NNS(0.997)VS(0.002)GLS(0.001)VK;NNS(0.997)VS(0.003)GLSVK 116.71 0.0062495 7396000.0 30170.0 25718.0 28817.0 37605.0 35847.0 23506.2 23932.6 31589.0 23137.0 35487.0 True False 28493.272180079126 27690.48790359627 26962.945593577297 32483.13412775666 31343.57938375394 26743.965681961738 25045.513321547216 31680.91876015953 27765.046501794048 34462.39810370098 0.8267930773227061 0.8034985789518384 0.7823873867524529 0.9425674333518954 0.9095008214297163 0.7760332174646214 0.7267489988996887 0.9192894430860068 0.8056620557352423 1.0 15.072735476119261 -10.992696430009937 2.857961792755559 1.005066295872701 0.8334549674329088 0.36423286960695633 0.06637890571742384 63763742.38230071 70798137.0349049 2572909.1462815767 0.0172168559563857 1.0169592946963796e-11 10.992696430009937 -0.1716113284397922 NNSNT(ph)CNIENELEDSRK ddPTM_A459_Selumetinib_30min_R1 1 NNSNTCNIENELEDSRK 17 1 Q6PL18;A0A0B4J211 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 NNS(0.021)NT(0.979)CNIENELEDSRK 169.43 1.269e-06 13293000.0 770.85 745.23 866.03 1024.7 746.99 772.23 849.05 767.42 547.94 591.25 True False 788.8093051870038 657.9781251519722 748.4278827622755 845.7553810012741 679.4248863917963 764.4620673287404 785.0054749259235 747.0655286685251 929.814160045804 667.142696762702 1.1823696924431413 0.9862629514567113 1.1218407791826372 1.267727856581938 1.018410138773449 1.1458748945889372 1.1766680183042526 1.1197987061743269 1.3937260567457466 1.0 9.381851565717627 -7.36668602048628 1.959146225845068 1.1907633121535748 1.115528869835036 0.04100592371957423 0.1169439191426085 1.0162934271591348 7.608922864707673 0.06201489380063107 0.03606186404875762 4.2984707865504665e-08 7.36668602048628 -0.07523444231853871 NNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPS(ph)PHTLR ddPTM_A459_Selumetinib_30min_R2 2 NNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLR 38 0 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7;Q68EM7-2 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 NNSQIASGQNQPQAAAGS(0.371)HQLS(0.131)MGQPHNAAGPS(0.433)PHT(0.064)LR;NNSQIAS(0.001)GQNQPQAAAGS(0.003)HQLS(0.025)MGQPHNAAGPS(0.725)PHT(0.246)LR 58.804 0.00017109999999999998 23527500.0 55410.0 37747.4 55453.0 79663.0 66369.0 51418.7 50302.1 56980.0 46437.8 56635.0 True False 52330.5340238046 40642.504202978824 51885.21435266132 68812.76197365983 58031.13287361186 58501.15919251453 52641.2473217202 57145.80236645317 55726.657580542436 54999.80039459821 0.9514677080345226 0.7389573036881515 0.9433709573563691 1.2511456674380632 1.0551153360060443 1.063661300091922 0.9571170612264684 1.0390183592750952 1.013215633161018 1.0 15.747138762364095 -5.525037396009496 24.999871196319432 1.0556634220654362 0.844200384287678 0.48606345672435713 0.08703369126610495 50.17587699416358 581097.2716959316 0.02352166537430619 0.041082475985484423 2.98512556616925e-06 5.525037396009496 -0.2114630377777582 NNTAAETEDDES(ph)DGEDR ddPTM_A459_Selumetinib_30min_R2 1 NNTAAETEDDESDGEDR 17 0 A0A590UJS4;Q6KC79-2;Q6KC79 A0A590UJS4 NIPBL Nipped-B-like protein 1 NNTAAETEDDES(1)DGEDR 153.36 0.00035036 0.0 851.4 872.27 2161.6 1238.1 3450.3 1159.4 574.34 964.9 1145.6 1234.2 True False 804.0825964242414 939.1703042098883 2022.5250093721293 1069.4686441583713 3016.842467926639 1319.0968260146878 601.0479480331197 967.707699252206 1374.7520107384387 1198.565439163293 0.6708708345416365 0.7835786628934621 1.6874548049575289 0.8922905743927984 2.5170444344137506 1.1005630422111425 0.5014727843752157 0.8073882890597559 1.146997874140389 1.0 10.227092963927861 -7.001998719854492 24.996265670037047 0.8412142762545479 1.3317323740732872 0.13979986208050976 0.5193368543211314 151.27789204528636 1891924.8577895435 0.19065365897486303 0.16559275726027886 9.954083514566211e-08 7.001998719854492 0.49051809781873923 NNTAAETEDDES(ph)DGEDRGGGTSGVR ddPTM_A459_Selumetinib_30min_R1 1 NNTAAETEDDESDGEDRGGGTSGVR 25 1 A0A590UJS4;Q6KC79-2 A0A590UJS4 NIPBL Nipped-B-like protein 1 NNTAAETEDDES(1)DGEDRGGGTSGVR 156.69 4.2691999999999996e-13 15811000.0 910.54 1148.8 1127.0 1681.3 1188.6 907.43 1223.7 1039.8 490.02 775.9 True False 931.7538103975803 1014.2979619373697 973.9595901678745 1387.6925169097701 1081.091339864374 898.3020780805184 1131.3953237934772 1012.2211262535928 831.5281503552301 875.4943229060133 1.0642602539155546 1.1585431628735499 1.1124681961786196 1.5850388524549492 1.234835351388603 1.0260512884867143 1.2922931584959412 1.1561709765218633 0.9497813162227631 1.0 9.77395401338856 -8.15806148261225 4.136349907945633 0.9754439488433665 1.2135202070337523 0.2825580037010237 0.14741397205627593 0.3073547645891727 8.768919062229317 0.11721344513960977 0.039957645725415734 6.949259306928299e-09 8.15806148261225 0.2380762581903858 NNTAAETEDDES(ph)DGEDRGGGTSGVR ddPTM_A459_Selumetinib_30min_R2 1 NNTAAETEDDESDGEDRGGGTSGVR 25 1 A0A590UJS4;Q6KC79-2 A0A590UJS4 NIPBL Nipped-B-like protein 1 NNTAAETEDDES(1)DGEDRGGGTSGVR 124.07 4.2229e-08 16179000.0 4615.9 6139.7 5426.7 6080.5 8506.6 2625.6 3200.8 6809.8 4182.7 6127.3 True False 4359.366756911739 6610.595247752933 5077.552030144215 5252.3254105524375 7437.924858031116 2987.2525671762646 3349.6435422648774 6829.615390576925 5019.356874402643 5950.3889283627 0.732618793392259 1.1109517927884243 0.8533143112615574 0.8826860687235211 1.2499896977453075 0.5020264394714502 0.5629285047736468 1.1477594948497176 0.8435342521020323 1.0 12.538768253365408 -6.7579032589123695 24.999966499854327 0.8049646620318271 0.9630907147210217 0.10974238545297632 0.21981696131809028 227.20259712017085 1606297.731717058 0.07587841605947952 0.07302902991533741 1.7462110861285773e-07 6.7579032589123695 0.15812605268919455 NNTAAETEDDES(ph)DGEDRGGGTSGVRR ddPTM_A459_Selumetinib_30min_R1 1 NNTAAETEDDESDGEDRGGGTSGVRR 26 2 A0A590UJS4;Q6KC79-2 A0A590UJS4 NIPBL Nipped-B-like protein 1 NNTAAET(0.001)EDDES(0.855)DGEDRGGGT(0.065)S(0.08)GVRR 53.99800000000001 0.013966 1995400.0 0.0 0.0 297.07 294.99 206.69 182.78 185.38 163.8 0.0 141.16 True False 0.0 0.0 256.72952568870477 243.47553414810756 187.9949259940833 180.94139915096164 171.39663734970574 159.4554919026146 0.0 159.2792610148381 0.0 0.0 1.6118201707677964 1.5286078840196646 1.1802850213912663 1.1360009959746455 1.0760762967988582 1.0011064270806735 0.0 1.0 7.315414622495869 -5.243334940014508 24.999999999999996 1.0901345259512336 2.770300017604564e-05 0.5195987271875022 0.40979103389768756 661.6478972000714 913651.0435473758 0.10923115801414605 0.2877443645830099 5.710380663238025e-06 5.243334940014508 -1.0901068229510575 NNTS(ph)ALGFLDIAR ddPTM_A459_Selumetinib_30min_R2 1 NNTSALGFLDIAR 13 0 Q8ND23-3;Q8ND23 Q8ND23-3 LRRC16B Leucine-rich repeat-containing protein 16B 1 NNT(0.003)S(0.997)ALGFLDIAR 91.549 0.019639 1938100.0 8659.5 8278.8 8024.0 9560.1 8751.7 8879.3 7051.3 7178.8 5846.2 7972.7 True False 8178.239656725061 8913.757339462347 7507.744575870643 8257.997887907635 7652.233204809313 10102.34297673987 7379.199421885877 7199.689119485679 7015.603356476128 7742.507435437682 1.056277920934634 1.1512752701616817 0.9696787040213196 1.0665792647625416 0.9883404399180579 1.304789573788609 0.9530761815107941 0.9298911469600264 0.9061151590717895 1.0 12.91858514804009 -7.483860127266586 24.999916484992106 0.9390983926715408 1.0851901354351903 0.3727548668984334 0.09020968139285368 558.8988358339935 358097.1919117988 0.03709557042260878 0.025004533056498135 3.2820097941193166e-08 7.483860127266586 0.14609174276364945 NNVGERDDDVPADMVAEESGPGAQNS(ph)PYQLR ddPTM_A459_Selumetinib_30min_R1 2 NNVGERDDDVPADMVAEESGPGAQNSPYQLR 31 1 Q86XK2-4;Q86XK2;Q86XK2-5 Q86XK2-4 FBXO11 F-box only protein 11 1 NNVGERDDDVPADMVAEES(0.004)GPGAQNS(0.994)PY(0.003)QLR;NNVGERDDDVPADMVAEESGPGAQNS(1)PYQLR 197.66 9.6523e-48 14795000.0 2514.71 2846.58 3169.8 3082.88 2601.6 2401.7 2366.97 2259.78 1631.63 2528.88 True False 2573.2978502261294 2513.301090260859 2739.358570465065 2544.512880824833 2366.285739349785 2377.541078569123 2188.4275472415193 2199.8432936000627 2768.7569404597853 2853.486381377187 0.9018083517133068 0.8807825776437932 0.9600040807424354 0.8917207025872562 0.8292612695798944 0.833205686239036 0.7669311343218367 0.7709317654210585 0.9703066951815944 1.0 11.478509962249262 -6.106067460949037 4.8373801092601605 0.844492909676842 0.9130070246132882 0.06412173121970899 0.07431536563854874 0.4370317921752773 15.97255141735621 0.021764291042158528 0.028690304096226603 7.833079585062627e-07 6.106067460949037 0.06851411493644621 NNVGERDDDVPADMVAEESGPGAQNS(ph)PYQLR ddPTM_A459_Selumetinib_30min_R2 1 NNVGERDDDVPADMVAEESGPGAQNSPYQLR 31 1 Q86XK2-4;Q86XK2;Q86XK2-5 Q86XK2-4 FBXO11 F-box only protein 11 1 NNVGERDDDVPADMVAEES(0.002)GPGAQNS(0.996)PY(0.002)QLR 89.86 3.8908e-07 4183800.0 30742.0 29628.0 33702.0 39879.0 34509.0 26501.0 22492.0 24539.0 20435.0 36686.0 True False 29033.482709976543 31900.3723309647 31533.650011963153 34447.41140488787 30173.670905625713 30151.27219787408 23537.922567052487 24610.404427349873 24522.571001606124 35626.77985832489 0.8149342383856313 0.8954043126496755 0.8851108670882223 0.9668965744833816 0.8469379221365427 0.8463092178910088 0.6606806076960782 0.6907838576828093 0.6883184811853252 1.0 15.12067447030749 -7.076455291111367 4.758788993599305 0.7344788585139703 0.8844896289476211 0.24640651403252978 0.09661157116159982 0.2477515225526528 10.2362412857134 0.035745651667231364 0.027836443048467798 8.385804026936897e-08 7.076455291111367 0.15001077043365074 NNYYS(ph)SRFSPDSQYIDNR ddPTM_A459_Selumetinib_30min_R2 1 NNYYSSRFSPDSQYIDNR 18 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 NNYY(0.001)S(0.47)S(0.262)RFS(0.262)PDS(0.005)QYIDNR 102.29 0.011085 3969400.0 9922.2 12849.0 10006.0 9622.9 11482.0 6038.1 4903.8 4349.9 2007.1 12035.0 True False 9370.763845713667 13834.476983953198 9362.224853709078 8312.244419571589 10039.528509617623 6869.793466585543 5131.83641669536 4362.557488835291 2408.5760830596378 11687.518279314725 0.8017753317484526 1.1836967141637151 0.8010447239495581 0.7112069663482881 0.8589957482578817 0.5877888960177386 0.439086921111216 0.37326636712572325 0.20608105377875482 1.0 13.512681000930993 -6.66295080788897 1.1580032381287044 0.44644114768500953 0.9283402588594821 0.36529133948167747 0.22550246735966634 0.4406396064504381 1.2538491965222625 0.10843637012246596 0.10763957665402539 2.1729472925386592e-07 6.66295080788897 0.4818991111744726 NNYYSSRFS(ph)PDSQYIDNR ddPTM_A459_Selumetinib_30min_R1 3 NNYYSSRFSPDSQYIDNR 18 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 NNYYS(0.002)S(0.005)RFS(0.816)PDS(0.121)QY(0.056)IDNR;NNYY(0.001)S(0.01)S(0.007)RFS(0.956)PDS(0.022)QY(0.003)IDNR;NNYY(0.001)S(0.002)S(0.001)RFS(0.93)PDS(0.058)QY(0.008)IDNR 116.61 0.0049235 64334400.0 4750.61 4337.63 6623.4 7583.3 5308.1900000000005 5448.639999999999 4449.67 4246.54 2979.02 3977.17 True False 4861.28996992208 3829.77826309052 5723.978659731944 6259.019011171038 4828.065151737064 5393.831628569291 4114.027809450132 4133.907964494072 5055.1793609877905 4487.678510416431 1.0832527237943743 0.8533985342758295 1.2754876817592693 1.394711986752865 1.0758491590987536 1.2019202391725636 0.9167385319382813 0.9211684738331376 1.1264575546697748 1.0 12.131753612114844 -7.258506729000029 24.971211556837353 0.9845218452904255 1.1478776528963166 0.22181156554174453 0.14325086509233997 428.043823408807 3644773.7308896505 0.06090704754622044 0.04508518778867564 5.514336583499774e-08 7.258506729000029 0.16335580760589108 NNYYSSRFS(ph)PDSQYIDNR ddPTM_A459_Selumetinib_30min_R2 4 NNYYSSRFSPDSQYIDNR 18 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 NNY(0.001)Y(0.002)S(0.095)S(0.063)RFS(0.814)PDS(0.022)QY(0.003)IDNR;NNYY(0.001)S(0.022)S(0.022)RFS(0.955)PDSQYIDNR;NNY(0.003)Y(0.011)S(0.027)S(0.079)RFS(0.809)PDS(0.047)QY(0.024)IDNR;NNYYS(0.003)S(0.002)RFS(0.916)PDS(0.077)QY(0.002)IDNR 84.03 0.0045463000000000005 45654000.0 108660.0 133642.0 133370.0 129368.0 119644.0 81231.0 68995.0 62367.0 43122.9 127200.0 True False 102621.11220044405 143891.9116732408 124789.11940227642 111747.85522775214 104613.25108906906 92419.83290840012 72203.40421099878 62548.47764458731 51748.68495449775 123527.40549470979 0.8307558293599789 1.164858203707704 1.0102140403784379 0.9046401871731846 0.8468829299061839 0.7481727033630453 0.5845132415906766 0.5063530428255131 0.4189247296763952 1.0 16.914471624628213 -6.679979974777522 1.3059000584959541 0.5861303277799399 1.006505256693106 0.47188527433329597 0.16442864961128523 0.3274379366355244 1.1716859185863746 0.07371320461909017 0.07161981853866864 2.089392470057473e-07 6.679979974777522 0.4203749289131662 NNYYSSRFSPDSQY(ph)IDNR ddPTM_A459_Selumetinib_30min_R1 1 NNYYSSRFSPDSQYIDNR 18 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 NNYYS(0.006)S(0.004)RFS(0.001)PDS(0.299)QY(0.69)IDNR 119.21 0.0056035 4420000.0 538.6 847.51 1168.5 1129.6 840.5 815.36 630.76 560.22 554.83 503.57 True False 551.1483320668357 748.2831352032906 1009.8241181110567 932.3365652181501 764.4769234023275 807.1582186876464 583.1812653722103 545.361145748979 941.5059868201145 568.2081146871777 0.9699761721464781 1.316917368586423 1.7772081953933498 1.640836413840095 1.3454171167956726 1.4205327200087958 1.0263515256083169 0.959791195606601 1.6569738489892085 1.0 9.150275624849089 -7.236597494621768 20.050058746760822 1.1574287822348075 1.431502437149426 0.16986171477805656 0.26973531725463495 113.62009037319544 91702.8231497924 0.10682935482153583 0.08263801038722761 5.7996596154463926e-08 7.236597494621768 0.27407365491461855 NPARS(ph)PVTEIR ddPTM_A459_Selumetinib_30min_R2 1 NPARSPVTEIR 11 1 Q86YC2 Q86YC2 PALB2 Partner and localizer of BRCA2 1 NPARS(0.998)PVT(0.002)EIR 66.78399999999999 0.042165 5968700.0 14911.0 12456.0 15548.0 13504.0 13842.0 8377.9 10043.0 9475.9 9385.5 13118.0 True False 14082.306313462374 13411.335147647376 14547.65860738244 11664.731904300661 12103.044210949933 9531.879677995905 10510.019399826971 9503.473300180302 11262.862252780744 12739.249255342786 1.1054267038190115 1.0527571035650096 1.1419557240613072 0.9156530083127562 0.9500594554953047 0.748229309823597 0.8250108926488832 0.7459994784382279 0.8841072206870549 1.0 13.636992639285923 -6.074740316316492 1.6365776720639542 0.8294809604720477 1.0977822514323794 0.6309743302788287 0.0805503535810478 0.21489408770651286 1.152244719396137 0.026339505560206703 0.04155161535903196 8.418983990802661e-07 6.074740316316492 0.26830129096033173 NPCEVQPDS(ph)LTNNACVR ddPTM_A459_Selumetinib_30min_R2 1 NPCEVQPDSLTNNACVR 17 0 Q5W0Q7-2;Q5W0Q7 Q5W0Q7-2 USPL1 SUMO-specific isopeptidase USPL1 1 NPCEVQPDS(0.616)LT(0.384)NNACVR 65.51100000000001 0.043273 39147000.0 1156.3 586.98 1441.8 1567.4 1205.7 1601.3 1071.0 1862.6 1044.3 1141.8 True False 1092.0374750356477 631.999478561822 1349.0361577131455 1353.917416084187 1054.2291869052406 1821.8645398458839 1120.8036221462398 1868.0198576299701 1253.1891801799497 1108.8332672473246 0.9848527342137089 0.5699679990038168 1.2166266990366585 1.2210288562547218 0.9507553732784024 1.643046428764405 1.0107954507250956 1.6846715487417907 1.1301872131695583 1.0 10.11482673167695 -5.337192255426885 7.202646518522342 1.254578423141763 0.7791015159173206 0.3327580695713609 0.25615167636102293 0.24485588449618922 20.171380660822294 0.0632953322701813 0.13310684499891848 4.6005287023089955e-06 5.337192255426885 -0.47547690722444236 NPCHNGGLCEEIS(ph)QEVR ddPTM_A459_Selumetinib_30min_R2 2 NPCHNGGLCEEISQEVR 17 0 H0YKS8;Q08431-3;Q08431 H0YKS8 MFGE8 Lactadherin;Lactadherin short form;Medin 1 NPCHNGGLCEEIS(1)QEVR;NPCHNGGLCEEIS(1)QEVR 143.69 0.00032789 6422400.0 36251.0 23868.5 29923.0 35435.0 33570.0 28861.0 36613.0 33614.0 23692.0 27960.0 True False 34236.31454425088 25699.13720067608 27997.786757699036 30608.69187121548 29352.636480392237 32836.340775927114 38315.57704728315 33711.81117490273 28431.062009789686 27152.722151195656 1.260879640487291 0.9464663269330597 1.0311226477329887 1.1272789409760025 1.081020028745063 1.209320398635655 1.4111136568160236 1.2415628527844766 1.0470796206537156 1.0 14.728809219831932 -6.762377273055662 8.798117127712867 1.211378340054011 1.0801742322817314 0.09003005694203581 0.12947523867608832 0.18861989198758647 161.01336028089747 0.04440311770610929 0.04159994375146379 1.728314314521376e-07 6.762377273055662 -0.13120410777227964 NPDDITNEEYGEFYK ddPTM_A459_Selumetinib_30min_R1 2 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ; 250.05 6.9557e-27 39865000.0 4968.5 5227.4 5432.9 5598.0 4729.0 5009.9 5213.8 4855.9 3529.8 4123.8 False True 5084.256382981943 4615.373577847669 4695.142020783535 4620.414387474512 4301.262784972761 4959.504954625244 4820.518868345536 4727.105757813832 5989.812793608199 4653.129899213583 1.0926530084279882 0.991885822621824 1.0090287876074668 0.9929691385266077 0.9243805520451321 1.0658427901321734 1.0359734141873502 1.015898085848141 1.287265329648443 1.0 12.183985747350494 -8.068422391168788 24.999533947091944 1.146282954857517 1.0133632456198292 0.3033112062309222 0.07722747457219346 191.95405519032767 70132.67505352218 0.04844565311633414 0.01831075261579712 8.542354864623295e-09 8.068422391168788 -0.13291970923768792 NPDDITNEEYGEFYK ddPTM_A459_Selumetinib_30min_R2 4 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ;;; 261.45 2.4868000000000003e-35 52748000.0 154232.0 144151.0 177440.0 174233.0 179467.0 138590.0 143130.0 154096.0 119583.0 151554.0 False True 145660.40287961438 155206.91818148014 166023.70358206463 150502.1648313106 156920.75100466362 157679.5145052403 149785.82860671452 154544.39384803385 143502.9414281905 147178.24223541867 0.9896870669689313 1.0545506986910418 1.1280451584446956 1.0225843341067706 1.0661953059179856 1.071350711289406 1.0177172001220458 1.0500491886622254 0.9750282327645322 1.0 17.167204884016726 -8.029655627525461 1.512147681451545 0.9889914593283052 1.0558762042243282 0.29404912235439307 0.03645461290434057 0.5081716692725955 2.0804921564106644 0.03262029421602774 0.010751378594971354 9.339946154025799e-09 8.029655627525461 0.06688474489602292 NPDDITQEEYGEFYK ddPTM_A459_Selumetinib_30min_R1 2 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 255.08 1.4699000000000002e-27 34949000.0 5715.3 5701.2 7388.799999999999 7252.6 6595.1 6154.1 5922.1 6336.5 3627.3 5683.1 False True 5848.455369962101 5033.700853584024 6385.441543773191 5986.069558163211 5998.574369459475 6092.195341475724 5475.391229089936 6168.435436147233 6155.263172489952 6412.581243081794 0.9120282688459815 0.7849726440525999 0.9957677418375194 0.9334882992120022 0.9354383425443584 0.9500379192931523 0.853851362116785 0.9619270621798426 0.9598729340280173 1.0 12.646689483471249 -1.5228787457444075 0.08323702697236952 1.0491334392180574 0.5898469336465144 0.23390613687785755 0.05446319105243398 283.1603287066154 1.7174334314825241 1.3660055145415564 14.910375113662226 0.029999999967943183 1.5228787457444075 -0.45928650557154294 NPDDITQEEYGEFYK ddPTM_A459_Selumetinib_30min_R2 4 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ;;; 286.74 5.040099999999998e-56 55433000.0 95183.0 89156.0 100412.0 104427.0 110976.0 83603.0 81836.0 86783.0 76902.0 95065.0 False True 89893.10990773847 95993.97851827607 93951.6012403194 90203.86245337722 97034.20274197232 95118.55437752785 85641.53615495772 87035.52416230092 92284.54882140992 92320.22644146696 0.9737098074031768 1.039793577403521 1.017670827528643 0.9770758362531579 1.0510611431774826 1.030311103470214 0.9276573450483933 0.9427568314889624 0.9996135449247444 1.0 16.49435914215482 -7.24707712466962 24.989971416181675 0.9627366648022091 1.0161121954346906 0.3536466596698561 0.03112280404797323 798.7055645529184 1389730.7081180904 0.011853706580244015 0.009135762125008356 5.6613874173116315e-08 7.24707712466962 0.05337553063248146 NPDVDTSFLPDRDREEEENRLR ddPTM_A459_Selumetinib_30min_R1 1 NPDVDTSFLPDRDREEEENRLR 22 3 B0S8I6;Q9Y247;Q14320 B0S8I6 FAM50A;FAM50B Protein FAM50B;Protein FAM50A 0 53.188 0.015265 19578000.0 984.04 898.81 1188.6 1238.5 1083.7 979.74 1050.4 853.67 741.26 656.82 False True 1006.9662173914763 793.5769073545674 1027.1946485124538 1022.2192245243273 985.6795263427744 969.8847051327447 971.1674823181083 831.0278984890407 1257.8640805116474 741.1292449685884 1.3586917858492482 1.070767228175164 1.3859858526510984 1.3792725512641892 1.3299698170520189 1.3086579860626761 1.310388827469991 1.1212995629719922 1.697226346215713 1.0 9.533581344742938 -5.295207618401615 24.9212612815284 1.3231425510829395 1.2147291985125572 0.04641815858340115 0.18277571522957026 1621.0392897169847 1196338.1085164838 0.04433404907135834 0.09229546054404464 5.067483947098563e-06 5.295207618401615 -0.10841335257038232 NPDVDTSFLPDRDREEEENRLR ddPTM_A459_Selumetinib_30min_R2 1 NPDVDTSFLPDRDREEEENRLR 22 3 B0S8I6;Q9Y247;Q14320 B0S8I6 FAM50A;FAM50B Protein FAM50B;Protein FAM50A 0 53.188 0.015265 6733600.0 6952.8 9410.2 11508.0 10953.0 9511.9 7664.0 4091.3 3639.3 4125.8 9844.0 False True 6566.391210263648 10131.932081437964 10767.587808963024 9461.182505021116 8316.93008453508 8719.646433134862 4281.5535567571515 3649.8897604814533 4951.075284483809 9559.77814221638 0.6868769455293308 1.0598501273470906 1.1263428553234833 0.9896864094826779 0.869991955964665 0.9121180746474166 0.4478716444108291 0.38179649215533434 0.5179069232391129 1.0 13.222761422027293 -7.202818242054681 5.788032324276016 0.5357557020727746 0.956511078445092 0.43913923500293284 0.1922120690971733 0.17312248997858162 12.401977095267501 0.07324682302597448 0.055974842734981815 6.268761656899222e-08 7.202818242054681 0.4207553763723174 NPEAALS(ph)PTFR ddPTM_A459_Selumetinib_30min_R2 3 NPEAALSPTFR 11 0 B4E349;F5H6D8;B4DTN4;Q86U44 B4E349 METTL3 N6-adenosine-methyltransferase 70 kDa subunit 1 NPEAALS(0.905)PT(0.095)FR;NPEAALS(0.972)PT(0.028)FR;NPEAALS(0.791)PT(0.209)FR 151.3 0.00059833 43609000.0 83313.0 82011.0 85532.0 90549.0 93315.0 64067.0 69659.0 78698.0 61131.0 82713.0 True False 78682.79698836373 88300.97999307245 80028.96424020019 78216.0699942626 81591.93545331547 72891.64770767905 72898.28152668996 78926.99815084484 73358.9081428523 80324.86077581716 0.9795572158906525 1.0992982638278859 0.9963162521197167 0.9737467234778022 1.0157743775122705 0.9074606168458375 0.9075432042160094 0.9825973850253699 0.9132777503043984 1.0 16.293558954677046 -6.065879797801701 1.1716117302492897 0.9428490295973629 1.036939815971492 0.35285788006867 0.04488253827172443 0.48951185848090034 1.3723670874099165 0.017228451765294327 0.03131355862013757 8.592513085567184e-07 6.065879797801701 0.09409078637412904 NPEAALSPT(ph)FR ddPTM_A459_Selumetinib_30min_R1 1 NPEAALSPTFR 11 0 B4E349;F5H6D8;B4DTN4;Q86U44 B4E349 METTL3 N6-adenosine-methyltransferase 70 kDa subunit 1 NPEAALS(0.26)PT(0.74)FR 161.87 0.001445 37209000.0 2329.8 2651.1 3259.9 3344.3 2683.1 2839.0 2982.9 2938.6 1405.0 2211.1 True False 2384.0798069983553 2340.7079795370482 2817.2234853489367 2760.2807852859974 2440.4140787397796 2810.442237605755 2757.8974514534334 2860.6587820819486 2384.1823828600836 2494.916222937861 0.9555750950991886 0.9381910133963429 1.1291856052912055 1.1063621134483062 0.9781547197068192 1.1264675790581655 1.105406837350996 1.1465951264341099 0.9556162090495431 1.0 11.284775656624891 -5.248462569260435 24.666620642408418 1.0752268192991883 0.9468830262346584 0.3564386148150639 0.06484652145771663 647.8605009735779 1231461.3498176772 0.016060488317456573 0.04189184308267032 5.643355779008499e-06 5.248462569260435 -0.12834379306452992 NPEAALSPT(ph)FR ddPTM_A459_Selumetinib_30min_R2 1 NPEAALSPTFR 11 0 B4E349;F5H6D8;B4DTN4;Q86U44 B4E349 METTL3 N6-adenosine-methyltransferase 70 kDa subunit 1 NPEAALS(0.087)PT(0.913)FR 167.73 0.0012163 18139000.0 39834.0 44212.0 53827.0 50579.0 51666.0 30066.0 43380.0 37155.0 31273.0 44277.0 True False 37620.18574813632 47602.91823601361 50363.829422406416 43690.052946358344 45175.25518009963 34207.318588026224 45397.25595583928 37263.11489865863 37528.47384062779 42998.60796453824 0.8749163642498007 1.1070804495641493 1.1712897650998937 1.0160806364334016 1.0506213414479955 0.7955447910369016 1.0557843173267203 0.866612122173588 0.8727834601431336 1.0 15.392002334360345 -6.651588592477923 13.325083948648835 0.9184308406534378 1.0533072053951738 0.2910521801738637 0.0976783898692412 0.6900479555655512 79.66800737038596 0.03176247448119702 0.03175980597141375 2.23054714792229e-07 6.651588592477923 0.13487636474173592 NPEDKSPQLSLSPRPAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 NPEDKSPQLSLSPRPASPK 19 2 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 NPEDKSPQLSLS(0.001)PRPAS(0.999)PK 124.04 0.00046151 9591300.0 1738.0 1070.5 3629.5 3919.0 1891.7 1654.5 1387.1 1564.0 1255.4 1517.3 True False 1778.4920184406997 945.1653623380519 3136.6338354164145 3234.6202187410863 1720.596069006761 1637.8572321658057 1282.4699302393826 1522.5176394120224 2130.3221092117797 1712.0602347535687 1.038802246754299 0.5520631477513976 1.8320814722198702 1.8893144955303938 1.0049857090772398 0.9566586495723127 0.7490799121468874 0.8892897624195863 1.2443032470282303 1.0 10.74151774507612 -6.491694475245169 24.825360178264024 0.9510003132094229 1.3259518315512047 0.17796859224985417 0.37255105969572966 1172.3147277385651 933264.1326491229 0.12697914938959978 0.14381607949479147 3.223335599949561e-07 6.491694475245169 0.37495151834178175 NPLPPILGS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 NPLPPILGSPTK 12 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 NPLPPILGS(0.809)PT(0.191)K 151.07 0.00053239 51544000.0 9061.5 10895.0 11380.0 12808.0 9391.7 11298.0 10003.0 9536.7 5632.7 8090.5 True False 9272.615319390332 9619.408335051912 9834.658505865485 10571.323235936678 8542.222393239312 11184.352377763242 9248.465656538494 9283.755736432622 9558.280503869039 9128.994483143577 1.0157323828502631 1.0537204675513683 1.0772992057367212 1.1579942627259026 0.9357243460944442 1.2251461427011292 1.0130870024749732 1.0169527162684573 1.0470244583363617 1.0 13.156240247382996 NPLPPILGS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 NPLPPILGSPTK 12 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 NPLPPILGS(0.921)PT(0.079)K 83.87700000000002 0.033597 25627000.0 140970.0 126320.0 144120.0 155640.0 135990.0 125310.0 131270.0 138720.0 98480.0 141840.0 True False 133135.45174762182 136008.3378171819 134847.4761059914 134441.56350602472 118905.72043397483 142570.31504907765 137374.3151065702 139123.6522336678 118178.75176110453 137744.7106554215 0.9665376704058707 0.9873942684987499 0.9789666366451067 0.9760197895535905 0.8632325689182084 1.0350329560437912 0.9973109998410183 1.0100108495758926 0.8579549167353318 1.0 17.071637395355182 NPLPPILGSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 NPLPPILGSPTK 12 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 NPLPPILGS(0.161)PT(0.839)K 132.51 0.0043815 19941000.0 124560.0 99274.0 121050.0 130640.0 105990.0 92080.0 105940.0 112360.0 67474.0 101400.0 True False 117637.45385318715 106887.99658377825 113261.774789275 112846.60663342991 92674.58863737785 104763.18418098366 110866.41991612765 112686.94899780054 80970.68538108007 98472.31853116014 1.194624597124343 1.0854623733669386 1.1501889716695861 1.1459728816857424 0.9411232518918737 1.0638846098442667 1.1258638119812887 1.1443515363370103 0.8222684972676668 1.0 16.587430606347198 -1.522878745282965 0.1599069513738471 0.9593005739548368 1.7856431267419453 0.294005157701545 0.09183964385651144 92.85072622576574 0.961258960382751 0.2804279197156847 18.063528706721677 0.029999999999818498 1.522878745282965 0.8263425527871084 NPMS(ph)DPK ddPTM_A459_Selumetinib_30min_R2 1 NPMSDPK 7 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4;H0YCR0 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 NPMS(1)DPK 89.679 0.030647000000000008 13889000.0 144790.0 143720.0 126460.0 131020.0 105880.0 80192.0 125880.0 109230.0 88551.0 131990.0 True False 136743.1514402934 154742.8618673633 118323.70127923759 113174.84997789314 92578.40782079028 91237.72008950298 131733.6694264879 109547.84121600004 106263.6743216651 128179.10574879486 1.0668131177969236 1.2072393621674038 0.9231122388318743 0.8829430453329342 0.7222581814716764 0.7117986941515294 1.027731225435909 0.8546466335214702 0.82902493117654 1.0 16.96780158437064 -5.414732508764319 3.8535876141759804 0.852428934136141 1.135579597672191 0.5348469573429626 0.10078724807744696 0.17125031994279327 4.458328585083458 0.027791905039984247 0.06194010028074011 3.848287332921173e-06 5.414732508764319 0.28315066353605 NPPGFAFVEFEDPRDAEDAVR ddPTM_A459_Selumetinib_30min_R1 2 NPPGFAFVEFEDPRDAEDAVR 21 1 Q16629;C9JAB2;Q16629-4;A0A0B4J1Z1;Q16629-3;Q16629-2 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 0 ; 122.1 0.00020516 10679000.0 781.49 572.03 728.24 1018.21 655.96 805.63 368.09000000000003 340.8 539.5 348.29 False True 799.6971964851679 505.0564616704677 629.3490079359827 840.3987376688855 596.628533819144 797.5260936535138 340.324674949041 331.7608769255863 915.4920964790139 392.9964141318927 2.034871484137214 1.2851426718132006 1.6014115785920842 2.1384386916742733 1.5181526150488251 2.0293469990437565 0.8659739954645626 0.8441829619703468 2.3295176840259093 1.0 8.618372338549351 -7.254668776009729 24.959975343659114 1.246933904997855 1.7438744314939894 0.22296417306313288 0.4630160499684183 840.9051212108901 3100022.2251352686 0.17648596815259016 0.13354767420982497 5.56328391277921e-08 7.254668776009729 0.4969405264961344 NPPGFAFVEFEDPRDAEDAVR ddPTM_A459_Selumetinib_30min_R2 1 NPPGFAFVEFEDPRDAEDAVR 21 1 Q16629;C9JAB2;Q16629-4;A0A0B4J1Z1;Q16629-3;Q16629-2 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 0 69.612 0.019218 1893300.0 728.33 0.0 828.22 1017.9 444.48 456.61 1132.8 581.3 0.0 764.91 False True 687.8523343359968 0.0 774.9332268977538 879.2602640245583 388.64044869838375 519.5038828071125 1185.4774446006159 582.9914867606047 0.0 742.8250608251453 0.9259950567256258 0.0 1.0432243979988263 1.1836707057888676 0.5231924300812818 0.6993623535399263 1.5959039444411893 0.7848301269117197 0.0 1.0 9.536878678335976 -5.292309843380072 24.953650039881474 0.8670539798581268 0.4629969390973589 0.10764109244125875 0.4487557674396315 1276.5969471507462 1031914.7305629214 0.11833476283366588 0.24637479009059193 5.101409147983504e-06 5.292309843380072 -0.4040570407607679 NPQMPQYSSPQPGSALS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 NPQMPQYSSPQPGSALSPR 19 0 O14497-2;O14497;H0Y488;A0A1B0GTU5;O14497-3;A0A087WUV6 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 NPQMPQYSSPQPGS(0.003)ALS(0.997)PR;NPQMPQYSSPQPGS(0.271)ALS(0.729)PR;NPQMPQYSSPQPGS(0.004)ALS(0.995)PR;NPQMPQYSS(0.004)PQPGS(0.463)ALS(0.532)PR 221.86 2.3119e-41 13577300.0 2820.6099999999997 3584.8199999999997 3912.8199999999997 3704.3599999999997 3470.45 3389.49 2813.16 3017.8900000000003 1521.6 2398.47 True False 2886.324725048344 3165.1076078623937 3381.480535581775 3057.4630654492817 3156.54841025771 3355.3948080106843 2600.96107631189 2937.8457537117315 2582.0440667330254 2706.3369875762173 1.0665060331726548 1.1695171822253552 1.2494676572447887 1.1297421863888175 1.1663545318813753 1.2398288991408124 0.9610632704840273 1.0855432147579125 0.95407337614873 1.0 11.40212577661339 -7.2660729732456275 24.99730253245203 1.0072985623515889 1.1717877747791319 0.6660344705732798 0.05890385316220644 251.13818652500575 1354832.5106788932 0.02374154316166309 0.016589044476208382 5.419098272104662e-08 7.2660729732456275 0.164489212427543 NPQMPQYSSPQPGSALS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 NPQMPQYSSPQPGSALSPR 19 0 O14497-2;O14497;H0Y488;A0A1B0GTU5;O14497-3;A0A087WUV6 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 NPQMPQYSSPQPGS(0.004)ALS(0.996)PR;NPQMPQYS(0.003)S(0.047)PQPGS(0.124)ALS(0.826)PR;NPQMPQYSSPQPGS(0.004)ALS(0.996)PR;NPQMPQYS(0.078)S(0.078)PQPGS(0.066)ALS(0.777)PR 207.1 2.3758e-16 41582000.0 83410.9 77009.8 92349.8 97966.5 105994.09999999999 72604.09999999999 79550.7 87533.9 62647.7 87334.0 True False 78775.25609828837 82916.20403446478 86408.1144108598 84623.29369836138 92678.17355872343 82604.6557406011 83249.96517672154 87788.6091569827 75178.99052299083 84812.44049901716 0.9288172305241146 0.9776420009447275 1.0188141492268592 0.9977698224512479 1.0927426803594624 0.973968621284496 0.9815772861492681 1.0350911804972764 0.88641465898935 1.0 16.371988277944723 -10.611039211679579 14.716096183398838 1.0000065309507205 0.9928255851224781 0.0 0.05348145722114088 0.0 0.0 0.050938560081113894 0.012354415507723761 2.4488421302442885e-11 10.611039211679579 -0.007180945828242358 NPQNS(ph)SQSADGLR ddPTM_A459_Selumetinib_30min_R1 1 NPQNSSQSADGLR 13 0 P0DN76;Q01081 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 NPQNS(0.614)S(0.193)QS(0.193)ADGLR 110.22 0.0056688 2051000.0 873.97 671.75 940.27 1073.5 878.82 679.43 937.99 739.74 475.3 675.59 True False 894.331800550413 593.1011977118973 812.5864985334048 886.0333770907265 799.3308861682729 672.5955510730813 867.236659119919 720.1196921858369 806.5493854614936 762.308557303871 1.1731887199502014 0.7780329789417222 1.0659548430196777 1.162302808490626 1.0485660675190926 0.8823140506934801 1.1376451842376756 0.9446564455904215 1.058035329308244 1.0 9.574231260968567 -10.992390358404915 2.865511580707407 0.9993156946913974 1.022692990076247 0.003156385963710817 0.12033221851413203 64445537.027242206 53905859.60337952 336060.17575365305 0.030015018251778505 1.0176762553862151e-11 10.992390358404915 0.02337729538484956 NPQNSSQS(ph)ADGLR ddPTM_A459_Selumetinib_30min_R2 1 NPQNSSQSADGLR 13 0 P0DN76;Q01081 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 NPQNS(0.004)S(0.012)QS(0.984)ADGLR 117.48 0.003607500000000001 2569000.0 5855.9 5536.3 3993.8 4157.3 7086.1 4273.8 3121.7 4022.4 4283.1 5044.1 True False 5530.452521025037 5960.916407989736 3736.843256120656 3591.068568257488 6195.880767462242 4862.4771563063405 3266.865235531199 4034.104518055835 5139.839679813028 4898.463726854289 1.1290177552415195 1.2168950798412335 0.7628602485376357 0.7331009819610549 1.2648620287816508 0.9926534986161756 0.6669162859411688 0.8235448383418915 1.0492758477796764 1.0 12.258113641815275 -7.031512631582961 24.367926540355665 0.8644517994259786 1.0145290395653268 0.10273467164053851 0.18774773496173272 1144.646167561548 885122.4071496656 0.07578732633355643 0.05877577740281259 9.300094647612946e-08 7.031512631582961 0.1500772401393482 NPS(ph)PGTSAK ddPTM_A459_Selumetinib_30min_R2 1 NPSPGTSAK 9 0 Q9P212-2;Q9P212 Q9P212-2 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 1 NPS(0.933)PGT(0.054)S(0.012)AK 80.706 0.045729 2703400.0 15619.0 14044.0 15423.0 13440.0 13781.0 15332.0 30675.0 59239.0 21578.0 39594.0 True False 14750.958507810938 15121.129641422582 14430.700971292734 11609.44881470682 12049.707576296847 17443.84382996134 32101.448281359393 59411.37568245563 25894.2029396945 38450.81834243347 0.38363184825983554 0.39325898103799883 0.3753028308208289 0.3019298239979171 0.3133797431561829 0.45366638687922806 0.8348703529654906 1.5451264301673018 0.6734369788722606 1.0 15.230726682704223 -7.344361339348277 3.1977562536970705 1.0954785334843535 0.3598461615622348 0.7117041226166929 0.20366194111193353 0.12496373527059913 2.4766762481804414 0.08703463972535014 0.05622952844603083 4.525209192215823e-08 7.344361339348277 -0.7356323719221187 down NPS(ph)SSVPPPSAGSVK ddPTM_A459_Selumetinib_30min_R2 1 NPSSSVPPPSAGSVK 15 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 NPS(0.941)S(0.022)S(0.036)VPPPSAGSVK 118.31 0.0024239 0.0 8238.4 5790.8 7866.3 9355.8 7636.5 5336.8 6489.5 7641.8 5709.2 7764.6 True False 7780.542708928201 6234.935739643254 7360.19082217986 8081.523900344791 6677.134598823805 6071.895757353096 6791.274608700294 7664.036372831909 6851.199528376302 7540.415823146409 1.03184531084409 0.8268689533678245 0.9760987981043007 1.071761039429334 0.8855127827735129 0.8052468059804506 0.9006498803227116 1.0163943942330116 0.9085970441239518 1.0 12.880428369091003 -9.363795877129702 0.9506506705002091 1.0003167463494942 0.9325378534293064 0.04701836367960388 0.08337492622711715 17.436353919063222 16.654343796612338 0.1111009661652849 0.0271099044323359 4.327171647618243e-10 9.363795877129702 -0.0677788929201878 NPSDSAVHS(ph)PFTK ddPTM_A459_Selumetinib_30min_R2 1 NPSDSAVHSPFTK 13 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 NPS(0.069)DS(0.001)AVHS(0.921)PFT(0.01)K 77.051 0.043892 40195000.0 79351.0 46230.0 59419.0 74879.0 68088.0 60226.0 62799.0 65871.0 49466.0 74955.0 True False 74940.98908722104 49775.6923471209 55596.04623051563 64680.351026520184 59534.176725556856 68521.5848228053 65719.27793385781 66062.67370446892 59360.58219551987 72790.85439352173 1.0295385280419331 0.6838179433644738 0.7637779044322303 0.888577989163933 0.8178799001822858 0.9413488190750459 0.9028507562030584 0.9075683237254101 0.8154950603355312 1.0 16.151469577913538 -6.75007413935718 24.894935056694237 0.9070129978987042 0.8270527980002833 0.13817248080713873 0.09359946637591957 411.3722160739157 901087.0321414181 0.030342469757890143 0.03008470560103829 1.7779758619970045e-07 6.75007413935718 -0.07996019989842085 NPSDSAVHS(ph)PFTKR ddPTM_A459_Selumetinib_30min_R2 1 NPSDSAVHSPFTKR 14 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 NPSDS(0.001)AVHS(0.997)PFT(0.002)KR 66.20100000000001 0.035851999999999995 17500000.0 30538.0 28881.0 35033.0 38644.0 41720.0 21301.0 20702.0 21664.0 17151.0 40713.0 True False 28840.820213299856 31096.07983294829 32779.01492104638 33380.620535381706 36478.76061846778 24235.019398774224 21664.68402023478 21727.03865333173 20581.67923897954 39537.50990492232 0.729454644024237 0.7864956571045185 0.8290611877144412 0.8442772601424224 0.922636774703059 0.612962714572903 0.5479526675385691 0.5495297682018858 0.5205608367465037 1.0 15.27093439171559 -6.780186747181468 24.483302702833694 0.6119061621780777 0.8219783522870461 0.27673904282666606 0.13690945153820236 206.00604122140751 269033.38121450914 0.045875305143133815 0.04053204429406969 1.658873436357116e-07 6.780186747181468 0.21007219010896838 NPSINQILLS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 NPSINQILLSPEK 13 0 Q14997-3;Q14997-2;Q14997 Q14997-3 PSME4 Proteasome activator complex subunit 4 1 NPSINQILLS(1)PEK 133.86 0.0012798 4340400.0 21112.0 18655.0 19979.0 17073.0 21654.0 16094.0 20877.0 22180.0 14784.0 18335.0 True False 19938.67955803218 20085.778514720747 18693.572891490454 14747.627947432255 18933.630930783846 18310.80241321405 21847.821866990704 22244.540127903343 17741.213099473705 17805.620909948935 1.1197969258624052 1.1280583034033802 1.0498691950161296 0.828256875849355 1.0633513443052487 1.0283720239704106 1.2270182532518805 1.249298760228808 0.9963827259492399 1.0 14.120045125168161 -7.222947501111304 24.0481885166026 1.1389498519161485 1.0328476769084398 0.10702802165128777 0.10921915827920647 639.6556638275769 399631.42816510727 0.0432849786197551 0.0335275778278677 5.984839373164118e-08 7.222947501111304 -0.10610217500770869 NPYLLS(ph)EEEDDDVDGDVNVEKNETEPPKGK ddPTM_A459_Selumetinib_30min_R1 1 NPYLLSEEEDDDVDGDVNVEKNETEPPKGK 30 2 G3V5V3;O60524-4;O60524-5;O60524-3;O60524 G3V5V3 NEMF Nuclear export mediator factor NEMF 1 NPY(0.004)LLS(0.995)EEEDDDVDGDVNVEKNET(0.001)EPPKGK 43.845 0.017363 11075000.0 1266.8 1656.9 4029.3 5253.6 2244.1 2196.9 1548.0 1371.3 1013.1 912.94 True False 1296.313975236294 1462.9093777280875 3482.1431913606175 4336.157382285834 2041.121551228034 2174.8011806256022 1431.2331136980497 1334.9286693898364 1719.1567061035955 1030.124741788653 1.2584048539455954 1.4201283770623456 3.3803121603645905 4.209351747786161 1.9814314407048808 2.1112017723692325 1.3893784467431913 1.29589030846103 1.6688820648250275 1.0 10.008603334170727 -7.02184598984547 2.0542828369992687 1.3523882763477766 2.549240903770928 0.2868432188303841 0.829815205728314 0.4836151518281588 4.082500090515416 0.41303509945238287 0.3165427568207612 9.509419583201804e-08 7.02184598984547 1.1968526274231515 NQALNTDNYGHDLASVQALQR ddPTM_A459_Selumetinib_30min_R2 1 NQALNTDNYGHDLASVQALQR 21 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 100.59 0.0003756 2981500.0 8098.6 7706.3 9130.9 9188.6 8530.7 4916.9 7279.7 5854.3 4674.5 7316.9 False True 7648.512233264463 8297.34843033999 8543.427834972228 7937.0968287808855 7458.997200574385 5594.158343825785 7618.22047445189 5871.335043768464 5609.530616442762 7105.642085410706 1.0763998722885828 1.1677126895226109 1.202344240292314 1.117013316091071 1.049728808588486 0.7872840028505942 1.0721368150661021 0.8262919766003244 0.789447392510839 1.0 12.794749305922341 -6.544060124190333 4.126976828435833 0.8951497861596697 1.142760378885381 0.6280139658784609 0.08948198562505696 0.13839391810147694 5.425492380132586 0.02988440540690203 0.03107610415495424 2.85719496288146e-07 6.544060124190333 0.2476105927257114 NQAS(ph)DSENEELPKPR ddPTM_A459_Selumetinib_30min_R2 1 NQASDSENEELPKPR 15 1 Q96ST2;Q96ST2-3 Q96ST2 IWS1 Protein IWS1 homolog 1 NQAS(0.5)DS(0.5)ENEELPKPR 189.45 0.00012443 4230400.0 11696.0 7972.1 11169.0 10983.0 11454.0 7755.9 9650.5 11641.0 10061.0 8275.5 True False 11045.98314279766 8583.534435658286 10450.39869988773 9487.096453268226 10015.046119940796 8824.204823949729 10099.267372102975 11674.873382728701 12073.481127827707 8036.564812668795 1.3744657574819574 1.0680601271487604 1.3003564263444727 1.1804915003376595 1.2461849500862776 1.0980070502311265 1.2566647078093052 1.452719371381725 1.5023186410187521 1.0 12.972363245423383 -7.539257204897839 18.421762586703746 1.3574523814757686 1.2063526229604753 0.07423422756237052 0.15101389610429147 19.572825566720315 22007.308469585678 0.06625586627526643 0.03831943475134527 2.8889684240454983e-08 7.539257204897839 -0.15109975851529334 NQDFS(ph)SFDDTGK ddPTM_A459_Selumetinib_30min_R1 1 NQDFSSFDDTGK 12 0 Q8NHV4-2;Q8NHV4;Q8NHV4-3 Q8NHV4-2 NEDD1 Protein NEDD1 1 NQDFS(0.657)S(0.343)FDDTGK 86.699 0.029531 4246300.0 1155.6 1277.8 1220.0 1522.7 1463.6 2124.6 1508.4 1545.1 1080.3 1066.5 True False 1182.5232315938274 1128.1945819668958 1054.3307009803075 1256.7890296190499 1331.2176384195666 2103.228452982456 1394.6201735801935 1504.1189288078735 1833.190198009785 1203.39566358972 0.9826553870622815 0.9375092632472184 0.8761297160031698 1.044368920085733 1.106217745914552 1.747744749809503 1.1589041042578234 1.2498955865613628 1.5233478509814409 1.0 10.232895347831441 -6.532761294101399 24.925280458892377 1.3501355424771546 0.9678884174478796 0.4589469656597899 0.19305902682378354 174.5279622120107 440182.4927355715 0.06173209766491025 0.061799911691470664 2.9325046260999754e-07 6.532761294101399 -0.38224712502927505 NQESLGS(ph)PHICDLGK ddPTM_A459_Selumetinib_30min_R1 1 NQESLGSPHICDLGK 15 0 A0A087WUA7;A4D1E1 A0A087WUA7 ZNF804B Zinc finger protein 804B 1 NQES(0.001)LGS(0.999)PHICDLGK 100.09 0.0078165 11931000.0 5411.4 6001.2 6513.0 7356.5 5696.5 5853.2 5338.7 5161.9 3299.6 4920.4 True False 5537.475091248562 5298.5767141178085 5628.5703733481505 6071.825373607758 5181.25258079876 5794.322122280383 4935.997560787968 5024.989643785753 5599.180206750981 5551.981268754672 0.9973872070520577 0.9543578152788503 1.0137949140831048 1.0936321791607357 0.9332258755910632 1.0436494364434463 0.8890515514824726 0.9050804389534397 1.0085012783205762 1.0 12.438786985229498 -7.253009640732676 24.992312875170928 0.9427483527423703 1.004688774414364 0.19590509901611164 0.05395244987553628 938.1419175012899 2781388.4163007424 0.02075589328126074 0.015818195416603262 5.584577976138633e-08 7.253009640732676 0.06194042167199365 NQEY(ph)ICT(ph)QDYQQLY(ph)GT(ph)RCDS(ph)CR ddPTM_A459_Selumetinib_30min_R2 1 NQEYICTQDYQQLYGTRCDSCR 22 1 A0A0C4DGA7;O94929-3;O94929-2;O94929;D6RHE7 A0A0C4DGA7 ABLIM3 Actin-binding LIM protein 3 5 NQEY(0.998)ICT(0.998)QDY(0.116)QQLY(0.892)GT(0.998)RCDS(0.998)CR 47.397 0.039337 0.0 8518.6 6827.9 7096.2 8357.7 10853.0 6678.9 8747.5 7546.7 7224.6 6854.8 True False 8045.170314657675 7351.5779748411605 6639.638217758381 7219.366842163327 9489.549112948967 7598.857849982317 9154.276082842414 7568.659647576559 8669.72187219005 6656.8841130907 1.2085489514286305 1.1043572112641034 0.9974093141717151 1.0844963979418705 1.4255241569081634 1.1415037006636835 1.3751592978523715 1.1369673136855216 1.3023693555279299 1.0 12.700631337862646 NQGETPTTEVPAPFFLPAS(ph)LSANNTPTR ddPTM_A459_Selumetinib_30min_R2 1 NQGETPTTEVPAPFFLPASLSANNTPTR 28 0 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 NQGETPT(0.001)T(0.002)EVPAPFFLPAS(0.475)LS(0.475)ANNT(0.035)PT(0.012)R 63.761 0.010582 0.0 753.05 1028.5 472.38 956.31 887.32 954.25 708.58 723.38 1001.9 1002.0 True False 711.1984956979974 1107.3826428512618 441.987585088456 826.0589282732351 775.8469288585534 1085.689275680969 741.5303740246333 725.4849160379943 1202.3079954249663 973.0696564913458 0.7308813823898357 1.1380301867023748 0.45421988255409845 0.8489206530720567 0.7973190035090294 1.1157364413105866 0.7620527154226685 0.7455631888203335 1.2355826609167926 1.0 9.92639927276434 -6.614955771220199 24.74998551321739 0.9443074746527298 0.7970974840067325 0.148757965187435 0.20758553470857197 39.45014973586516 10586.577461593353 0.06749677601809602 0.06749677221084013 2.426857234922512e-07 6.614955771220199 -0.14720999064599727 NQGGGLS(ph)SSGAGEGQGPK ddPTM_A459_Selumetinib_30min_R1 1 NQGGGLSSSGAGEGQGPK 18 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 NQGGGLS(0.772)S(0.11)S(0.118)GAGEGQGPK 124.08 0.0010113 0.0 470.27 498.66 614.36 476.51 338.67 261.67 446.11 448.3 265.56 402.33 True False 481.2263760138711 440.2766553792552 530.9332864379193 393.29647370051424 308.0373582970449 259.0378373773507 412.45956353477845 436.40962771637413 450.6359242649993 453.9729745260682 1.0600330923140404 0.9698301002144204 1.1695261969992705 0.866343363525333 0.6785367754955568 0.5706018902287676 0.908555325271007 0.9613119110712932 0.9926492314557873 1.0 8.82646260474083 -5.877137501243688 6.997498598637147 0.8331452030077486 1.0556398059542493 0.3283484411094457 0.13740072193947317 0.26768601983750173 15.317584680856893 0.04260698910509417 0.06363764758094606 1.3269742601310235e-06 5.877137501243688 0.2224946029465007 NQGGGLSS(ph)SGAGEGQGPK ddPTM_A459_Selumetinib_30min_R2 1 NQGGGLSSSGAGEGQGPK 18 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 NQGGGLS(0.21)S(0.718)S(0.071)GAGEGQGPK 290.67 3.4318999999999985e-151 0.0 15890.0 10571.0 14712.0 14573.0 11608.0 8510.1 9288.0 11598.0 7582.8 12163.0 True False 15006.89741270989 11381.76170887768 13765.44593721446 12588.132260172795 10149.69926316333 9682.289028003788 9719.910403822845 11631.748259847735 9099.571881134281 11811.82258673078 1.2704980372434995 0.9635906419440957 1.1653955887111234 1.0657231064674229 0.8592830774960459 0.8197116877526355 0.8228967487830408 0.9847547382666129 0.7703783065076343 1.0 13.527943972054553 -6.186500831066806 4.024198591483758 0.8694161575438742 1.1155845284312609 0.5957630913671009 0.09748309549649616 0.1583394168923408 4.928627483328239 0.028008025552041196 0.036433088403067346 6.508773653189642e-07 6.186500831066806 0.24616837088738663 NQGGGLSSS(ph)GAGEGQGPK ddPTM_A459_Selumetinib_30min_R2 1 NQGGGLSSSGAGEGQGPK 18 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 NQGGGLS(0.078)S(0.028)S(0.894)GAGEGQGPK 260.11 1.3419e-42 3717200.0 17538.0 13202.0 16442.0 15111.0 13933.0 10627.0 12776.0 12091.0 8924.8 12640.0 True False 16563.3081701766 14214.550948879309 15384.139620696038 13052.855732071028 12182.611977399607 12090.772787698872 13370.109315163729 12126.182808227193 10710.009379747222 12275.050357335946 1.3493474721492982 1.158003473312373 1.2532852552822324 1.0633647400289679 0.9924694093103175 0.9849876322888611 1.0892101397509415 0.9878723471778033 0.8725022764038269 1.0 13.583441322633599 -5.1631656016682586 0.5634518686530439 0.9667433145474585 1.4606249170409378 0.7695075953696251 0.06501964262282499 1.3495213453736705 0.4405618654333183 0.03918933286041835 0.4125194778517501 6.868065025625801e-06 5.1631656016682586 0.49388160249347923 NQGGY(ph)GGSSSSSSYGSGR ddPTM_A459_Selumetinib_30min_R2 1 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGY(0.69)GGS(0.062)S(0.062)S(0.118)S(0.061)S(0.004)S(0.001)YGSGR 129.17 0.0089981 522040.0 752.6 603.44 369.21 0.0 2203.7 700.66 425.49 949.25 985.42 1034.2 True False 710.7735048965046 649.7219076345802 345.45543056545347 0.0 1926.8515046720402 797.1695550417893 445.2761280924398 952.0121603432028 1182.5315349352927 1004.3399588256993 0.7077021068917339 0.6469143260955704 0.34396264684058675 0.0 1.9185251843658253 0.7937248219953937 0.44335199867290787 0.9478983206605863 1.1774215737845775 1.0 9.97203197416516 -6.21764142887325 24.999822405119357 1.0013889902052895 0.43475833762862026 0.37207566975015005 0.39322869734072874 585.6541901423624 334290.51093317854 0.12093444245959513 0.15612489661449888 6.058408750971929e-07 6.21764142887325 -0.5666306525766692 NQGGYDRYS(ph)GGNYR ddPTM_A459_Selumetinib_30min_R1 2 NQGGYDRYSGGNYR 14 1 P98179 P98179 RBM3 RNA-binding protein 3 1 NQGGYDRYS(1)GGNYR;NQGGYDRYS(1)GGNYR 200.97 0.00030409 59237000.0 12270.099999999999 16847.3 11900.4 11607.6 11057.3 11551.900000000001 12975.3 11783.8 7579.599999999999 11335.4 True False 12555.96945654155 14874.810283902714 10284.391044218071 9580.550561637929 10057.169167324872 11435.698374286001 11996.562674526042 11471.25534482313 12862.02760791907 12790.409006146177 0.9816706760908137 1.1629659596307607 0.8040705374844629 0.749041766923496 0.7863055170864434 0.8940838693110441 0.9379342496992341 0.8968638406567644 1.005599398872896 1.0 13.642774778382304 -10.253614542669473 24.70066489488951 0.99999999832082 0.9084374467042516 0.04750274528564857 0.11489734216293558 0.0 0.0 0.12198982330889153 0.029586878044293836 5.576804977222404e-11 10.253614542669473 -0.09156255161656834 NQGGYDRYS(ph)GGNYRDNYDN ddPTM_A459_Selumetinib_30min_R1 3 NQGGYDRYSGGNYRDNYDN 19 2 P98179 P98179 RBM3 RNA-binding protein 3 1 NQGGYDRY(0.002)S(0.996)GGNY(0.002)RDNYDN;NQGGY(0.027)DRY(0.043)S(0.93)GGNYRDNYDN;NQGGYDRY(0.03)S(0.959)GGNY(0.008)RDNY(0.003)DN 105.06 0.019277 47345000.0 5069.1 4226.5 7049.3 8325.0 5394.400000000001 4594.16 4801.7 4531.0199999999995 3089.8999999999996 2875.94 True False 5187.200167248417 3731.6594151534587 6092.043779033185 6871.195029604376 4906.477472458672 4547.946921563532 4439.5039031291535 4410.8426307728 5243.334622633001 3245.0949130278664 1.5984740989928243 1.1499384502352195 1.8773083506974981 2.1174095716026815 1.5119673242101377 1.4014834830578273 1.368065964821606 1.3592337817500757 1.6157723466216458 1.0 11.664044959666814 -6.517739288128104 21.83333756540185 1.3819117140601846 1.6803758682470533 0.25539552850690395 0.26823292398391185 72.91977516209433 309784.6791738745 0.09207347306504482 0.09503585542978372 3.035713010040052e-07 6.517739288128104 0.29846415418686867 NQGGYGGS(ph)SSSSSYGSGR ddPTM_A459_Selumetinib_30min_R1 2 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGY(0.23)GGS(0.288)S(0.288)S(0.095)S(0.095)S(0.001)S(0.001)YGSGR;NQGGYGGS(0.287)S(0.287)S(0.287)S(0.095)S(0.032)S(0.011)YGS(0.001)GR 100.69 0.004356399999999999 684960.0 0.0 391.1 252.11 515.56 535.4399999999999 307.99 300.81100000000004 346.03999999999996 158.64 401.899 True False 0.0 345.3098301825426 217.87484674110274 425.52712425979985 487.00954653960986 304.89190023254554 278.12058408567447 336.8618951036675 269.20049339282826 453.48665147777257 0.0 0.7614553351400417 0.4804437926256839 0.9383454240012109 1.0739225618937107 0.6723282796505636 0.6132938713396868 0.7428264845413617 0.5936238531290551 1.0 8.824916274971194 -4.761128635018928 24.999624253185505 0.75468377459184 2.2420366313281038e-05 0.6182333809230041 0.17998136412949728 5.190925920459394 416960.9230275411 0.04613573474048969 0.2617023575777366 1.733290533059189e-05 4.761128635018928 -0.7546613542255267 NQGGYGGS(ph)SSSSSYGSGR ddPTM_A459_Selumetinib_30min_R2 1 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGS(0.244)S(0.244)S(0.244)S(0.244)S(0.022)SYGSGR 300.28 1.2897999999999992e-95 57744000.0 33908.0 37394.0 36796.0 35249.0 38525.0 26088.0 29062.0 30651.0 24058.0 35987.0 True False 32023.529104478726 40261.99955933895 34428.58542045565 30448.025392083364 33685.145082130184 29681.3851967148 30413.440585260505 30740.189335453797 28870.272236684134 34947.96180454498 0.916320364648964 1.1520557274416752 0.9851385786961177 0.8712389455605848 0.9638657976829261 0.8493023244879115 0.870249336867057 0.8795989164511459 0.8260931609731116 1.0 15.092920698377064 -5.606419299236275 4.545505454872875 0.8898543374986307 1.0419595554459125 0.38713657602463714 0.0723605537393697 0.17615193870841672 6.60025925354722 0.01874731110670624 0.0338367146781055 2.475031329857218e-06 5.606419299236275 0.1521052179472817 NQGGYGGSSSS(ph)SSYGSGR ddPTM_A459_Selumetinib_30min_R1 2 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGS(0.001)S(0.001)S(0.05)S(0.917)S(0.03)SYGSGR;NQGGYGGS(0.151)S(0.151)S(0.151)S(0.422)S(0.124)SYGSGR 232.73 4.4431e-19 155996000.0 1500.0 1914.22 2263.88 2188.62 1496.0 1929.71 1482.06 1466.8899999999999 755.11 1147.1 True False 1534.9470815080833 1690.1022325032643 1956.4575306027048 1806.418602485613 1360.6870641402525 1910.2988694364922 1370.2670209866478 1427.9833120697567 1281.3665189476703 1294.3414587002037 1.1858903778370038 1.3057622632288155 1.511546676846315 1.3956275527940243 1.051258193882373 1.4758847880487749 1.0586596077689496 1.1032508481214518 0.9899756438570986 1.0 10.33800254788809 -7.333164301972952 8.994888118475142 1.045624990549477 1.3199684308405155 0.5367010770734603 0.12875003992319353 0.36209668495751474 43.10010415796706 0.05500919154948861 0.0370343812567841 4.6433957337901117e-08 7.333164301972952 0.2743434402910385 NQGGYGGSSSS(ph)SSYGSGR ddPTM_A459_Selumetinib_30min_R2 3 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGS(0.124)S(0.124)S(0.014)S(0.236)S(0.236)S(0.236)YGS(0.031)GR;NQGGYGGS(0.042)S(0.042)S(0.042)S(0.637)S(0.214)S(0.025)YGSGR;NQGGYGGS(0.015)S(0.015)S(0.239)S(0.562)S(0.17)SYGSGR 163.34 5.2625e-06 112301000.0 53093.0 55717.0 68052.0 69149.0 71813.0 43931.4 49183.0 54801.0 40220.0 60720.0 True False 50142.30360811868 59990.314741607915 63673.60840941529 59730.786911321615 62791.20892363439 49982.551580456806 51470.10695426564 54960.46183720608 48265.123840694796 58966.85583049352 0.8503472484993612 1.0173565114961605 1.0798203077412136 1.0129552622412852 1.0648559778078448 0.8476380650875629 0.8728650396796112 0.9320568489389319 0.8185127587510858 1.0 15.847616649871961 -6.765314795229354 24.99917608775832 0.888633745914266 1.0103410024618424 0.357894787262551 0.0738834174436254 104.61694910073977 674848.2102660119 0.025314896052666583 0.023159201383536516 1.7166636248108897e-07 6.765314795229354 0.12170725654757641 NQGGYGGSSSSS(ph)SYGSGR ddPTM_A459_Selumetinib_30min_R1 2 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGS(0.007)S(0.007)S(0.08)S(0.206)S(0.694)S(0.007)YGSGR;NQGGYGGS(0.007)S(0.007)S(0.073)S(0.073)S(0.831)S(0.009)YGSGR 224.99 3.969100000000001e-15 3529500.0 1244.3899999999999 1743.7199999999998 1532.62 1480.37 1768.1000000000001 1371.73 1326.9299999999998 1063.52 819.38 1174.8 True False 1273.3818658385624 1539.564451766564 1324.4986220790483 1221.8511694865388 1608.1756671834091 1357.931641631188 1226.8386017825283 1035.3119948001747 1390.4280148525943 1325.5970235210527 0.9606100822829275 1.1614121218205293 0.9991713911373407 0.9217365064995815 1.2131708495480553 1.0243924945035319 0.9254989110671038 0.7810156302630927 1.0489070133541318 1.0 10.372426552928358 -7.217729267678771 4.824195875044845 0.9201273757437477 1.0529688085521398 0.19779949428048993 0.10427210048552875 0.2863261505063888 15.816574289138963 0.04078036494764043 0.03048555053490049 6.057183523396776e-08 7.217729267678771 0.1328414328083921 NQGGYGGSSSSSS(ph)YGSGR ddPTM_A459_Selumetinib_30min_R1 1 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGSSSSS(0.001)S(0.999)YGSGR 222.96 1.1689e-14 12679000.0 3089.0 4725.6 4636.4 5219.0 3847.4 3584.5 4240.9 4139.2 2305.3 3234.0 True False 3160.9676898523117 4172.324555128161 4006.8023459222095 4307.599622763394 3499.40334931364 3548.443184465596 3921.005498631821 4029.4149699835298 3911.9257275497166 3649.115401827616 0.866228480543306 1.143379722394776 1.0980201787850967 1.180450369041764 0.9589730561990463 0.9724118844496944 1.0745084950363675 1.1042169200692982 1.0720202834885615 1.0 11.83333106096453 -10.795000393170392 3.6265067341877804 0.9998748300443892 1.057134964593368 0.0271505342931192 0.08961898071115294 10046439.058156934 15053370.19035792 7683.45631927451 0.02170084864044344 1.603243939259365e-11 10.795000393170392 0.057260134548978936 NQGGYGGSSSSSSYGS(ph)GR ddPTM_A459_Selumetinib_30min_R1 2 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGSSSSSSYGS(1)GR;NQGGYGGSSSSSS(0.001)YGS(0.999)GR 223.93 8.0041e-15 12922400.0 2479.6 3334.9 2897.9 4360.4 3045.3 2624.8 2583.9 2498.84 1167.85 2121.14 True False 2537.3698555382944 2944.4483576470507 2504.381097025274 3598.9379948452747 2769.8531526913835 2598.396895127716 2388.9943426901755 2432.5626458237443 1981.7561536107817 2393.408980653257 1.0601488822214349 1.2302320169465533 1.0463657140376101 1.503687010426016 1.1572836799230943 1.085646839354012 0.9981555020480133 1.0163589530610855 0.8280056478562562 1.0 11.224851227274183 -7.094707876191537 1.7999263922982023 0.94978851727033 1.2092776932812301 0.4458841098826143 0.12647516851277096 0.34032781144958 2.186664910137213 0.06181564478137279 0.04388418892571221 8.040667877537655e-08 7.094707876191537 0.25948917601090016 NQGGYGGSSSSSSYGS(ph)GR ddPTM_A459_Selumetinib_30min_R2 4 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 NQGGYGGSSSSSSYGS(1)GR;NQGGYGGSSSSSSYGS(1)GR;NQGGYGGSSSSSSYGS(1)GR;NQGGYGGSSSSS(0.001)S(0.001)Y(0.001)GS(0.997)GR 259.34 1.5028999999999996e-42 35063000.0 42564.5 52144.0 49617.0 48461.0 46919.0 25903.300000000003 37550.3 42127.2 25225.7 42105.9 True False 40198.935489193864 56143.27713061373 46424.69623890496 41860.52820011213 41024.615758818065 29471.2444482545 39296.46335450786 42249.78317746659 30271.54486494816 40890.1932627335 0.9830947785182118 1.3730254775240103 1.1353503746145288 1.0237302604843146 1.0032874018281317 0.7207411385632653 0.9610241532001237 1.0332497796231301 0.7403130787483228 1.0 15.319467261159835 -6.005946557796036 1.860152362221751 0.9009813352434461 1.1891571670601928 0.43013104617229736 0.13211907042598328 0.30535802723504496 2.1231414244695466 0.04222359220531347 0.06813928187757541 9.864008599401691e-07 6.005946557796036 0.28817583181674666 NQGGYGGSSSSSSYGSGR ddPTM_A459_Selumetinib_30min_R1 2 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 ; 310.17 2.5533999999999996e-110 9525700.0 1057.49 913.5799999999999 1410.47 1216.46 1064.07 1100.8200000000002 983.5799999999999 770.88 845.96 765.94 False True 1082.1274594826548 806.6176288881809 1218.9359211571266 1004.0280967822877 967.8250563768172 1089.7467502645893 909.3877687151987 750.4337582288617 1435.5323335262046 864.2558598873983 1.252091550323584 0.9333088340219909 1.4103878003395183 1.1617255298831297 1.11983626758737 1.2609075631914948 1.0522205413032206 0.8683004571431356 1.66100387645996 1.0 9.755314670156329 -5.9803224521087195 24.968794022921486 1.1522633749513593 1.1910654425439566 0.004884656058258607 0.22444700245577962 2397.7594256196267 3042484.8835832602 0.061050859861968114 0.09054085688691135 1.0463513714901375e-06 5.9803224521087195 0.0388020675925973 NQGGYGGSSSSSSYGSGR ddPTM_A459_Selumetinib_30min_R2 4 NQGGYGGSSSSSSYGSGR 18 0 F8W6I7;P09651-2;P09651;P09651-3;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 ;;; 284.51 2.7048999999999997e-66 16743890.0 16287.62 16589.47 15573.27 18630.65 17692.21 12075.11 11497.4 12891.559999999998 9025.159999999998 14982.539999999999 False True 15382.41928490886 17861.829005446507 14571.302763094327 16093.123330336126 15469.556409435809 13738.346795565127 12032.051881665899 12929.07230528735 10830.444184039916 14549.955140886084 1.0572142069141857 1.2276208986551371 1.001467195053286 1.1060599963716495 1.0632030311877456 0.9442191857320372 0.8269476960691958 0.8885987743670787 0.7443627199650835 1.0 13.828727084702187 -6.857542896680327 2.191710375783421 0.8549874234752393 1.100611122295207 0.6449435559805361 0.0797617290626222 0.18024132737426712 1.7711625562190985 0.030849813655952973 0.02668726336163269 1.3882161845235023e-07 6.857542896680327 0.24562369881996782 NQIPRT(ph)PENLITEIR ddPTM_A459_Selumetinib_30min_R1 1 NQIPRTPENLITEIR 15 1 Q7Z4H7;Q5VY60;Q7Z4H7-3;Q5SYF9 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 NQIPRT(1)PENLITEIR 92.236 0.018982 11149000.0 3766.1 3839.9 5874.0 6387.9 4513.0 3960.2 3601.6 3798.8 2434.1 2888.3 True False 3853.842802445061 3390.322722878922 5076.343063572398 5272.373180733906 4104.7999468348635 3920.363983573904 3329.9284123352063 3698.0434837585603 4130.489920369917 3259.0414394244594 1.1825080699574173 1.0402821767978643 1.5576184463824647 1.6177680703762385 1.2595114309315942 1.2029193419112316 1.0217508657770444 1.1347028113921829 1.2673941087104905 1.0 11.670231981038066 -6.77664527714557 3.0076757255720965 1.119227793836257 1.3490746660388635 0.28138336091316474 0.1704458835584162 0.3840496331034156 7.153966775776228 0.06934164729553115 0.06389620077217194 1.6724560845301301e-07 6.77664527714557 0.22984687220260658 NQKPSQVNGAPGS(ph)PTEPAGQK ddPTM_A459_Selumetinib_30min_R1 3 NQKPSQVNGAPGSPTEPAGQK 21 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 NQKPSQVNGAPGS(0.956)PT(0.044)EPAGQK;NQKPSQVNGAPGS(0.973)PT(0.027)EPAGQK;NQKPSQVNGAPGS(0.887)PT(0.113)EPAGQK 122.59 3.9858e-05 199758000.0 8601.3 9984.099999999999 11196.8 10933.0 8771.7 8624.8 9112.6 9079.0 5548.0 8870.8 True False 8801.69355478365 8815.156930517838 9676.33605961992 9023.756787827586 7978.3012837694205 8538.042342691839 8425.229245403647 8838.195427251752 9414.550790112275 10009.45358890922 0.8793380654200939 0.8806831314234076 0.9667197088901631 0.9015234156064407 0.7970766049217334 0.8529978451723129 0.8417271902573241 0.8829848051890408 0.9405659066688599 1.0 13.289075599868497 -8.476124539710247 2.4373222644048993 0.9990489512374418 0.8745978442521097 0.4893028166306893 0.04109546365576313 0.25825995673949215 3.41739069270592 0.04387513410656234 0.011997303939168038 3.340992188998233e-09 8.476124539710247 -0.12445110698533202 NQKPSQVNGAPGS(ph)PTEPAGQK ddPTM_A459_Selumetinib_30min_R2 3 NQKPSQVNGAPGSPTEPAGQK 21 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 NQKPSQVNGAPGS(0.996)PT(0.004)EPAGQK;NQKPSQVNGAPGS(0.997)PT(0.003)EPAGQK;NQKPSQVNGAPGS(0.992)PT(0.008)EPAGQK 160.12 5.8732e-08 695214000.0 465725.0 331904.0 392030.0 432255.0 396220.0 312941.0 395702.0 409461.0 261432.0 389793.0 True False 439841.86894489074 357359.9695604323 366807.2166099907 373381.12331853464 346443.3013482575 356045.78215444396 414102.9270686379 410652.4637200824 313725.70502040174 378538.6632861594 1.1619470125628586 0.944051438387109 0.969008590630278 0.9863751302895951 0.915212460309136 0.9405796994778529 1.0939514697752113 1.0848362493678654 0.8287811403382017 1.0 18.53008113655669 -4.755071780021092 24.967360284403274 0.9774485009870152 1.1619473248438401 0.3695725289001013 0.07363052885356461 244.04975081134043 956828.2441220172 0.018562798261458794 0.17076108876059523 1.7576330890450303e-05 4.755071780021092 0.18449882385682492 NQKPSQVNGAPGSPT(ph)EPAGQK ddPTM_A459_Selumetinib_30min_R1 1 NQKPSQVNGAPGSPTEPAGQK 21 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 NQKPSQVNGAPGS(0.363)PT(0.637)EPAGQK 145.66 4.727e-06 134990000.0 9272.5 10175.0 12076.0 11498.0 8487.6 8761.9 8680.1 9333.8 5578.3 8594.7 True False 9488.531208855804 8983.706269770828 10436.145528719831 9490.090144191128 7719.898078607486 8673.763241168679 8025.353068611395 9086.237303544709 9465.967677087838 9697.913464467478 0.9784095562020803 0.9263545506656191 1.0761227728992622 0.9785703057634201 0.7960370142394743 0.8943947863577852 0.827533994607785 0.9369270345457391 0.9760829184309106 1.0 13.243458665129612 -6.029717509863354 24.739314968580395 0.8966540952979376 0.9936423657098189 0.27330219653649845 0.06714195372847982 729.5761881134052 607358.56923568 0.01994895364321379 0.025797860558755877 9.338615405991893e-07 6.029717509863354 0.0969882704118813 NQKPSQVNGAPGSPT(ph)EPAGQK ddPTM_A459_Selumetinib_30min_R2 2 NQKPSQVNGAPGSPTEPAGQK 21 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 NQKPSQVNGAPGS(0.076)PT(0.924)EPAGQK;NQKPSQVNGAPGS(0.379)PT(0.621)EPAGQK 179.64 4.2631e-14 86944000.0 165349.0 113915.0 121514.0 141789.0 130775.0 106809.0 147381.0 139188.0 97165.0 140143.0 True False 156159.56452449135 122651.91420554326 113695.9215344396 122477.09360033229 114345.8753566665 121520.97023443389 154234.50852991114 139593.0140361863 116600.71501693486 136096.70745475704 1.1474161825436067 0.9012114730719458 0.8354053794595716 0.8999269408559913 0.8401810557737319 0.8929016175856525 1.1332714171735836 1.0256898689675615 0.8567489779699242 1.0 17.05427263902925 NQLTSNPENTVFDAK ddPTM_A459_Selumetinib_30min_R2 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 175.6 0.00026447 3251800.0 10441.0 8198.0 8367.3 8565.3 9324.6 6802.5 7061.6 9192.0 5080.9 7892.0 False True 9860.731018634615 8826.760239275303 7828.957027627419 7398.6913640333505 8153.1603850183365 7739.482628053222 7389.978392294942 9218.74719818248 6097.221972207516 7664.137454121459 1.2866067548582285 1.151696494499669 1.0215052997799938 0.9653651710088573 1.0638066493228016 1.0098308745612652 0.9642283213906758 1.202842101067096 0.7955522729995768 1.0 12.903907720292692 -4.971526326552746 2.0480488922525306 1.0084857697862273 1.312899521200786 0.4804282221829336 0.09505898933188968 0.4017737617367749 2.519397367569994 0.024132228999627067 0.19956885713640954 1.0677600638933394e-05 4.971526326552746 0.3044137514145586 NQPTVYIAAS(ph)PPNTDELMSR ddPTM_A459_Selumetinib_30min_R2 1 NQPTVYIAASPPNTDELMSR 20 0 A0A1B0GV57;Q9NYJ8;Q9NYJ8-2 A0A1B0GV57 TAB2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 1 NQPTVYIAAS(1)PPNTDELMSR 156.58 1.6259e-06 4508700.0 54181.0 56664.0 60416.0 64372.0 64141.0 48114.0 41303.0 37784.0 30876.0 54915.0 True False 51169.836923727766 61009.94659652302 56528.90033596713 55604.42255210616 56083.03415218461 54741.26676459433 43223.67134034183 37893.94518452209 37052.06274752097 53329.46126369486 0.9595041035706598 1.1440195559983428 1.0599938382360963 1.0426586212293134 1.0516332402998474 1.0264732751362067 0.8105026811843541 0.7105630600157438 0.6947766182056846 1.0 15.702645133482196 -7.2671729980222475 3.587798266914091 0.7738372967176727 1.0553807937641064 0.640351804951165 0.08875339507971512 0.1313372967232899 3.7018281620141256 0.03646543172510485 0.02525040169103407 5.405389603232173e-08 7.2671729980222475 0.2815434970464338 NQS(ph)FCPTVNLDK ddPTM_A459_Selumetinib_30min_R2 1 NQSFCPTVNLDK 12 0 P46776;E9PLL6;E9PJD9 P46776 RPL27A 60S ribosomal protein L27a 1 NQS(0.921)FCPT(0.079)VNLDK 173.33 0.00018814 5838100.0 26213.0 30342.0 33272.0 28786.0 27526.0 17296.0 17376.0 22918.0 21055.0 26876.0 True False 24756.186398953083 32669.13383509283 31131.315743814524 24865.29714138024 24067.937794437777 19678.367002544437 18184.018429890806 22984.68758572087 25266.588325853558 26100.020047765884 0.9485121602836535 1.251689990095975 1.1927698019710644 0.9526926452881659 0.9221425022046277 0.7539598424265912 0.6967051518202695 0.8806386946698272 0.9680677746458793 1.0 14.671763294497916 -5.9958758925469455 2.5966566945641447 0.8493727220732163 1.142035628986815 0.5016561670685058 0.11394138375753533 0.2143029456678145 2.9135818079798117 0.03605840529180414 0.054631212743904575 1.0095413394399033e-06 5.9958758925469455 0.29266290691359864 NQS(ph)LVEENEK ddPTM_A459_Selumetinib_30min_R1 1 NQSLVEENEK 10 0 O95239;O95239-2;Q2VIQ3 O95239 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 1 NQS(1)LVEENEK 137.62 0.0017258 15534000.0 3223.9 3233.3 3544.7 4170.5 2877.1 3012.5 2858.8 2611.6 1657.4 3208.2 True False 3299.0105973826085 2854.743732879611 3063.3492096433574 3442.2004649807864 2616.8668129932607 2982.196985131152 2643.158414366916 2542.3318843276434 2812.4867482934537 3620.0037205143344 0.9113279576723422 0.7886024306278905 0.8462281937124951 0.950883129062562 0.7228906418420623 0.8238104751747155 0.7301535076851725 0.7023009037036089 0.7769292424632791 1.0 11.821775464723281 -6.274121813080937 24.974458035766077 0.7762259622704174 0.8661397015262743 0.15228147067893338 0.08854590547910891 1238.9472323385232 2439750.6073989207 0.026219154831453612 0.029921931872649573 5.31959031819057e-07 6.274121813080937 0.08991373925585688 NQS(ph)LVEENEK ddPTM_A459_Selumetinib_30min_R2 1 NQSLVEENEK 10 0 O95239;O95239-2;Q2VIQ3 O95239 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 1 NQS(1)LVEENEK 89.507 0.030746 23092000.0 142420.0 115420.0 140680.0 140880.0 165690.0 122010.0 128770.0 129760.0 87979.0 133490.0 True False 134504.86655243195 124272.34286620571 131628.8019608028 121691.90096844472 144874.54091260617 138815.7700034948 134758.06015291414 130137.58011707554 105577.2583386495 129635.79685132712 1.0375596079120717 0.9586267519050121 1.015373879421294 0.938721432846262 1.1175504330702393 1.0708135667395615 1.0395127227663936 1.0038707153266 0.8144143894122919 1.0 16.984104624826855 -8.068389925323274 9.86960060847413 0.907371849516578 1.024256571489656 0.35114682568463806 0.06340760481101287 0.6129466482886989 85.45896849346578 0.042481801717198425 0.016047330065427585 8.542993475407704e-09 8.068389925323274 0.11688472197307809 NQS(ph)PPVGYMSQPK ddPTM_A459_Selumetinib_30min_R2 2 NQSPPVGYMSQPK 13 0 Q9H7U1-3 Q9H7U1-3 CCSER2 Serine-rich coiled-coil domain-containing protein 2 1 NQS(1)PPVGYMSQPK;NQS(0.988)PPVGY(0.002)MS(0.01)QPK 153.14 0.00041975 5947100.0 79940.0 71128.0 84519.0 84564.0 89289.0 69794.0 74465.0 76783.0 63315.0 77430.0 True False 75497.25482517485 76583.28888743256 79081.13955732941 73046.23731896323 78071.71756621207 79407.4899731491 77927.7700495982 77006.42581789011 75979.76916891072 75194.39471269965 1.0040276953306475 1.0184707142073495 1.0516892896003767 0.9714319477941936 1.0382651242091383 1.0560293792715096 1.0363507858177745 1.0240979545365556 1.010444587780935 1.0 16.198337501271624 NQS(ph)PVLEPVGR ddPTM_A459_Selumetinib_30min_R1 2 NQSPVLEPVGR 11 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 NQS(1)PVLEPVGR;NQS(1)PVLEPVGR 164.92 0.00065754 72419000.0 7368.8 8257.5 9077.9 9262.4 8060.5 7187.4 8280.3 7951.799999999999 3925.9 6083.1 True False 7540.4787028111805 7290.708061192397 7845.171041335355 7644.895716781688 7331.429198196864 7115.101281637058 7655.710304492223 7740.8924329133715 6661.965563608829 6863.925139411744 1.0985665708261818 1.0621776772200096 1.1429569644181328 1.1137790056720922 1.0681103085027508 1.0365936599137853 1.1153545746782922 1.127764693770653 0.970576663978561 1.0 12.744818103002403 -8.267401145651105 24.99914632795894 0.985288315335524 1.0944960856877934 0.6652009441026068 0.031312908380133286 326.72237607401735 1370005.3622826536 0.029129546060213656 0.008279547525113843 5.402550739272329e-09 8.267401145651105 0.10920777035226947 NQS(ph)PVLEPVGR ddPTM_A459_Selumetinib_30min_R2 4 NQSPVLEPVGR 11 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 NQS(1)PVLEPVGR;NQS(1)PVLEPVGR;NQS(1)PVLEPVGR;NQS(1)PVLEPVGR 147.7 0.00066196 105413000.0 266817.0 235825.0 282292.0 249713.0 262512.0 185671.0 209435.0 253289.0 187622.0 235549.0 True False 251988.37929307847 253912.01920311048 264129.6400562903 215701.65862104789 229532.8956729438 211245.4948964751 219174.14248757935 254026.02905574907 225151.64259668885 228748.0883401996 1.1015977493910916 1.110007174466466 1.154674742739141 0.942965950824696 1.0034308803996517 0.9234852908685548 0.9581463350269329 1.1105055823590337 0.9842777014242757 1.0 17.803400161205566 -5.757862319994077 24.999799359648563 0.990166801710216 1.1208846336055527 0.6066465849950768 0.04911260826077702 66.37536317790219 463882.98950140673 0.014257524172930079 0.023497403876338648 1.746375701074154e-06 5.757862319994077 0.1307178318953367 NQS(ph)QSQDALVLEDVEK ddPTM_A459_Selumetinib_30min_R2 1 NQSQSQDALVLEDVEK 16 0 Q92887 Q92887 ABCC2 Canalicular multispecific organic anion transporter 1 1 NQS(0.543)QS(0.457)QDALVLEDVEK 118.05 0.0017935 6176200.0 26811.0 11058.0 17382.0 23750.0 16499.0 12518.0 35673.0 23780.0 14891.0 16305.0 True False 25320.95195293673 11906.113042925874 16263.661044090657 20515.209028964808 14426.248117068553 14242.240872910006 37331.8651847085 23849.195863009078 17869.616089303494 15834.232284522357 1.599127226249387 0.7519223432489278 1.0271202766166352 1.2956238521913064 0.911079732685867 0.899458882312312 2.3576681530180434 1.5061794872316725 1.1285432579368362 1.0 13.950759300204961 NQS(ph)SEDILR ddPTM_A459_Selumetinib_30min_R2 2 NQSSEDILR 9 0 Q13625-2;Q13625;Q13625-3;H0Y847 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 NQS(0.921)S(0.079)EDILR;NQS(0.955)S(0.045)EDILR 127.52 0.0045443 25300000.0 101387.0 86825.0 100239.0 105444.0 104552.0 103829.0 85675.0 92170.0 74181.0 96840.0 True False 95752.31642431839 93484.19831362266 93789.73187197138 91082.34529895423 91417.243053261 118130.5022841807 89659.05726179174 92438.1994404352 89019.27279031786 94043.97757946303 1.0181653189159496 0.9940476861969457 0.9972965232433217 0.9685080070331314 0.9720690830629474 1.2561197997433233 0.9533737254576857 0.9829252422073385 0.9465706904527776 1.0 16.521047938455432 NQSFCPT(ph)VNLDK ddPTM_A459_Selumetinib_30min_R2 1 NQSFCPTVNLDK 12 0 P46776;E9PLL6;E9PJD9 P46776 RPL27A 60S ribosomal protein L27a 1 NQS(0.336)FCPT(0.664)VNLDK 148.48 0.0014075 5524200.0 39265.0 36792.0 37076.0 40881.0 39045.0 20405.0 28721.0 29381.0 25502.0 30863.0 True False 37082.80849024882 39613.828095074015 34690.57052529657 35312.93727634147 34139.8180332712 23215.60353185241 30056.583409581825 29466.49384571361 30603.112585415216 29971.904998295824 1.2372523031938516 1.3216987074170434 1.157436289994548 1.1782012947908829 1.1390606648196824 0.7745788441933347 1.0028252595652767 0.9831371695389081 1.0210599755722995 1.0 14.871323163242485 -6.562907875239718 8.855020725652661 0.9575598800464618 1.2176791414363761 0.7353361428525005 0.07643520452452882 0.15780404711646243 32.28724565014045 0.02618442129345335 0.02624000937570442 2.735849007001917e-07 6.562907875239718 0.26011926138991437 NQSHS(ph)SPSVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 NQSHSSPSVSPSR 13 0 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;Q7Z6E9-4 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 2 NQS(0.191)HS(0.499)S(0.307)PS(0.006)VS(0.994)PS(0.003)R 158.31 0.006636100000000001 2651700.0 848.4 838.2 898.3 1031.8 942.42 954.87 851.56 775.65 322.55 718.2 True False 868.1660693009716 740.0631543313915 776.3157940086967 851.6154992847808 857.1782773977652 945.2648747525917 787.326143605111 755.0772423337173 547.3437918800851 810.3879658604184 1.0712968428389829 0.9132208096718706 0.9579557282596787 1.050873822368018 1.0577381618539559 1.1664349849383184 0.971542244916209 0.9317478468871688 0.6754095753371044 1.0 9.662468940268164 -7.868337781103066 3.042841359835925 0.8312839580314926 1.0290591711932737 0.36896619676472653 0.0987964541080061 0.2574634899908082 4.662111396345372 0.06395005860423027 0.026911616355967193 1.3541357968323923e-08 7.868337781103066 0.19777521316178115 NQSLGQS(ph)APSLTAGLK ddPTM_A459_Selumetinib_30min_R2 2 NQSLGQSAPSLTAGLK 16 0 Q6P0Q8;Q6P0Q8-2 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 NQS(0.01)LGQS(0.613)APS(0.372)LT(0.005)AGLK;NQSLGQS(0.914)APS(0.086)LTAGLK 174.78 2.3092e-06 34269400.0 153617.0 117637.0 149445.0 159966.0 141744.0 137294.0 139854.0 120264.0 99679.5 129021.0 True False 145079.5821175744 126659.37963742728 139829.8714034131 138178.35484325836 123936.85151256234 156205.00226915674 146357.48811544373 120613.94832922309 119618.18527793493 125295.82849318378 1.1578963470876198 1.010882653960963 1.1159978196003546 1.102816881495583 0.9891538529497382 1.246689567782813 1.1680954575706861 0.9626333915481041 0.9546860954308808 1.0 16.934978857872494 -7.775111111692862 24.99734918601906 0.968994730007944 1.1092360952912808 0.4523749650881541 0.0707900530867092 230.3494142390937 421163.71855860285 0.039581674921067664 0.019176093379968905 1.678374560912458e-08 7.775111111692862 0.14024136528333675 NQSLGQSAPS(ph)LTAGLK ddPTM_A459_Selumetinib_30min_R1 1 NQSLGQSAPSLTAGLK 16 0 Q6P0Q8;Q6P0Q8-2 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 NQSLGQS(0.036)APS(0.95)LT(0.013)AGLK 180.78 9.9911e-07 31042000.0 1872.6 2049.7 2464.2 3109.0 2219.0 1727.2 1842.3 1859.4 1235.5 1887.8 True False 1916.2279365546908 1809.7201711203215 2129.575174881699 2566.0715131579573 2018.2918417962694 1709.8259361721246 1703.3338277557611 1810.0826718175924 2096.5532626502727 2130.117518729181 0.8995878958349228 0.8495870087956428 0.9997453925228473 1.2046619449845493 0.9475025786372452 0.8026908943466178 0.7996431242779332 0.849757187527137 0.9842430026588709 1.0 11.05671731089294 -6.532553983322234 23.92871788879431 0.8726997526699494 0.9913902145331384 0.16136971136732292 0.10653758819254866 210.25087228486296 519984.2885849941 0.037824445936726056 0.03787889695399077 2.933904793423352e-07 6.532553983322234 0.11869046186318899 NQSLGQSAPS(ph)LTAGLK ddPTM_A459_Selumetinib_30min_R2 1 NQSLGQSAPSLTAGLK 16 0 Q6P0Q8;Q6P0Q8-2 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 NQSLGQS(0.023)APS(0.974)LT(0.003)AGLK 193.19 1.1479e-06 30410000.0 246250.0 214050.0 243560.0 252830.0 245690.0 202190.0 221050.0 212020.0 140960.0 216560.0 True False 232564.4108168538 230466.9467207704 227889.6147680776 218394.11784392298 214824.22570353185 230039.83720192296 231329.2630022651 212636.94309819938 169155.93875147525 210307.35010954697 1.105831111921259 1.0958577843366981 1.0836027112194233 1.038452140308761 1.0214774975369718 1.093826901827718 1.099958051308088 1.0110770878309243 0.8043272794001903 1.0 17.68213974667146 -8.035928584247054 6.142330190141842 0.9018536840880047 1.0739629590959325 0.6503426155100372 0.05085445445848018 0.1140669372851274 12.541016279389336 0.03234239508965349 0.012565449374468721 9.206009437069432e-09 8.035928584247054 0.17210927500792783 NQSPT(ph)EAEKPASSSLPS(ph)SPPPQLLTR ddPTM_A459_Selumetinib_30min_R2 1 NQSPTEAEKPASSSLPSSPPPQLLTR 26 1 Q99567;I3L2W3 Q99567 NUP88 Nuclear pore complex protein Nup88 2 NQS(0.158)PT(0.818)EAEKPAS(0.022)S(0.039)S(0.031)LPS(0.488)S(0.443)PPPQLLT(0.002)R 62.594 0.011265 6480200.0 19257.0 17891.0 20005.0 22120.0 18833.0 14813.0 16987.0 17218.0 11613.0 16478.0 True False 18186.773031878824 19263.18217136794 18717.900079797113 19107.217840871635 16467.03017084381 16853.35629097426 17776.929159101932 17268.101529406653 13935.924494330906 16002.237325014372 1.1365143924874574 1.2037805576884004 1.169705191819501 1.1940341499000031 1.0290454913515676 1.053187498015008 1.1109027317894729 1.079105451236716 0.8708735042034749 1.0 13.965986006665181 -6.991464224346127 0.534860134004545 0.9665727283122373 1.1924097787766097 0.5906400389547226 0.061949226946563275 0.6911450431024878 0.4223133588022949 0.05785818382601082 0.05923868775111025 1.0198487681436201e-07 6.991464224346127 0.2258370504643724 NQSPT(ph)EAEKPASSSLPSSPPPQLLTR ddPTM_A459_Selumetinib_30min_R1 1 NQSPTEAEKPASSSLPSSPPPQLLTR 26 1 Q99567;I3L2W3 Q99567 NUP88 Nuclear pore complex protein Nup88 1 NQS(0.218)PT(0.78)EAEKPASS(0.001)S(0.001)LPSSPPPQLLTR 75.301 0.00027161 21772000.0 918.86 965.61 1272.6 1407.7 1283.5 953.12 1249.1 1254.5 563.85 872.16 True False 940.2676502096782 852.5559323000903 1099.787909891425 1161.8716208016917 1167.4076516203293 943.5324781637187 1154.8793813438208 1221.2265848097065 956.8122680253795 984.1102315578148 0.9554495218703953 0.8663215816286369 1.117545448288345 1.1806315832754695 1.1862570006739597 0.9587670648136003 1.173526444812675 1.240944912112685 0.9722612745431743 1.0 9.942676112671416 -5.268903516188904 24.469535064807165 1.1153545874677289 0.9108855479064537 0.3917460785442265 0.09524907474281108 351.55486972816743 1152500.095789534 0.024397620654256668 0.05251954920168982 5.383893789917849e-06 5.268903516188904 -0.20446903956127516 NQSPT(ph)EAEKPASSSLPSSPPPQLLTR ddPTM_A459_Selumetinib_30min_R2 2 NQSPTEAEKPASSSLPSSPPPQLLTR 26 1 Q99567;I3L2W3 Q99567 NUP88 Nuclear pore complex protein Nup88 1 NQS(0.05)PT(0.913)EAEKPAS(0.026)S(0.009)S(0.003)LPSSPPPQLLTR;NQS(0.028)PT(0.56)EAEKPAS(0.016)S(0.294)S(0.102)LPSSPPPQLLTR 89.631 6.882600000000001e-05 105742000.0 157906.0 159867.0 166391.0 161135.0 172304.0 112649.0 124374.0 118149.0 99823.0 139673.0 True False 149130.2166678017 172128.28484657514 155685.58421282296 139188.1350266208 150657.63110269603 128165.37722419234 130157.63744240563 118492.79402937999 119790.38928765977 135640.2775759638 1.0994537856521491 1.2690056959679743 1.147782848834359 1.0261563712052275 1.1107145590904732 0.9448917350704682 0.959579556813516 0.8735811821309453 0.8831476271535388 1.0 17.049426116265025 -6.421338991749846 0.8701250883686314 0.9090067631579827 1.1881939663480214 0.7114650358271662 0.06388851622316838 0.3048664389983809 0.5047488237061735 0.034296575451325785 0.04675378956438534 3.7901902339677354e-07 6.421338991749846 0.27918720319003876 NQSPTEAEKPASS(ph)SLPSSPPPQLLTR ddPTM_A459_Selumetinib_30min_R1 1 NQSPTEAEKPASSSLPSSPPPQLLTR 26 1 Q99567;I3L2W3 Q99567 NUP88 Nuclear pore complex protein Nup88 1 NQS(0.001)PT(0.001)EAEKPAS(0.059)S(0.791)S(0.066)LPS(0.041)S(0.041)PPPQLLTR 90.601 2.2276e-05 22311000.0 1975.0 2023.7 2431.7 2592.0 2183.0 1973.2 1911.9 2096.5 1208.6 1931.9 True False 2021.0136573189764 1786.7642632073948 2101.488496371978 2139.355857866011 1985.5480354399542 1953.3513995222534 1767.6838437204785 2040.8940096082497 2050.9059273485395 2179.878183299558 0.9271222918795777 0.819662436596742 0.9640394185656164 0.9814107385706248 0.9108527488607381 0.8960828244840618 0.810909461484144 0.9362422291501924 0.9408351086133628 1.0 11.090031800737666 -8.526610470768203 2.066450202897454 0.998385572049111 0.9037339873445791 0.24150315748496565 0.051866737720293446 0.5091768462812412 4.9917409500559735 0.052292620949793554 0.014560781022186579 2.974332586593435e-09 8.526610470768203 -0.09465158470453194 NQSPTEAEKPASSSLPS(ph)SPPPQLLTR ddPTM_A459_Selumetinib_30min_R1 2 NQSPTEAEKPASSSLPSSPPPQLLTR 26 1 Q99567;I3L2W3 Q99567 NUP88 Nuclear pore complex protein Nup88 1 NQS(0.001)PT(0.01)EAEKPAS(0.033)S(0.09)S(0.254)LPS(0.277)S(0.277)PPPQLLT(0.058)R;NQSPTEAEKPASSS(0.004)LPS(0.498)S(0.498)PPPQLLTR 136.42 2.2065e-09 74430000.0 2917.16 4080.3999999999996 4455.200000000001 4570.4 4001.9 3763.5 4156.8 4182.7 2360.55 3509.2 True False 2985.1241521947486 3602.6648710735053 3850.2083106618584 3772.2654370334963 3639.928851592833 3725.6426069845934 3843.2492293411206 4071.761208675618 4005.6809422493743 3959.64000250262 0.7538877651271464 0.9098465690811551 0.9723632219667451 0.952678888648792 0.9192575207070038 0.9409043763144799 0.9706057184269437 1.0283160100671105 1.0116275569793352 1.0 11.951153555822264 -4.052847304246386 1.1291859590015965 0.9751863819803701 1.0789398212967986e-13 0.8230370722590165 0.030998313373041746 3.2945087954904744 1.0667662917290381 0.010861438847699691 5.6824835713700965 8.854268667385853e-05 4.052847304246386 -0.9751863819802622 NQSPTEAEKPASSSLPS(ph)SPPPQLLTR ddPTM_A459_Selumetinib_30min_R2 4 NQSPTEAEKPASSSLPSSPPPQLLTR 26 1 Q99567;I3L2W3 Q99567 NUP88 Nuclear pore complex protein Nup88 1 NQS(0.002)PT(0.006)EAEKPAS(0.017)S(0.086)S(0.086)LPS(0.399)S(0.399)PPPQLLT(0.005)R;NQSPTEAEKPAS(0.003)S(0.059)S(0.059)LPS(0.437)S(0.437)PPPQLLT(0.004)R;NQSPTEAEKPAS(0.005)S(0.078)S(0.078)LPS(0.419)S(0.419)PPPQLLTR;NQSPTEAEKPAS(0.004)S(0.006)S(0.02)LPS(0.475)S(0.475)PPPQLLT(0.02)R 86.508 4.3642e-05 126076000.0 224593.0 202688.0 237211.0 236002.0 256644.0 173671.0 189279.0 209070.0 151706.0 240308.0 True False 212111.02017701394 218233.51785535942 221949.10251580834 203858.12047384222 224402.0862935296 197592.6038216291 198080.84854922336 209678.35908659818 182051.43901980203 233369.6836448323 0.9089056336033255 0.9351408222650344 0.9510622761677774 0.8735415727095727 0.9615734262855214 0.8466935410614316 0.8487856925353022 0.8984815671503837 0.7800989236325485 1.0 17.83225763147169 -6.771507292244066 24.999730190182383 0.866840398990138 0.9250231058952364 0.16309482979177103 0.056581848257603116 325.39732032786253 807992.2006046557 0.0184486259383159 0.016456398843374815 1.6923598277628561e-07 6.771507292244066 0.058182706905098414 NQSQS(ph)QDALVLEDVEK ddPTM_A459_Selumetinib_30min_R1 1 NQSQSQDALVLEDVEK 16 0 Q92887 Q92887 ABCC2 Canalicular multispecific organic anion transporter 1 1 NQS(0.001)QS(0.999)QDALVLEDVEK 280.19 1.4587999999999994e-62 6081400.0 1169.9 1016.5 1740.8 1019.0 1260.5 1171.1 1262.0 1363.1 507.72 1317.1 True False 1197.156393770872 897.4877074419702 1504.4089215299343 841.0507789990223 1146.4879975593499 1159.3197972737228 1166.8063239579712 1326.9461600271902 861.563757598378 1486.16261464043 0.8055352637574713 0.6038960330455581 1.0122774632531844 0.5659210982120624 0.7714418235697156 0.7800760063892568 0.7851134946227095 0.8928674069413585 0.5797237456459832 1.0 10.537376267631334 -6.951553632102491 2.5108549156882387 0.8044519266320858 0.7480684422819556 0.036107350238977154 0.14979641745387415 1.3582219708799868 17.342033500580264 0.05793605651969408 0.04768005115450943 1.1180117500154644e-07 6.951553632102491 -0.056383484350130186 NQSQS(ph)QDALVLEDVEK ddPTM_A459_Selumetinib_30min_R2 1 NQSQSQDALVLEDVEK 16 0 Q92887 Q92887 ABCC2 Canalicular multispecific organic anion transporter 1 1 NQS(0.019)QS(0.981)QDALVLEDVEK 132.67 0.0005999 6715900.0 22482.0 5530.3 10763.0 15884.0 10659.0 8950.8 23357.0 18149.0 10885.0 10771.0 True False 21232.540442576694 5954.456227282777 10070.520297868354 13720.571798571658 9319.921127330976 10183.691452727502 24443.146781017454 18201.810585271312 13062.304152311362 10460.01324358112 2.0298770133590636 0.5692589568121993 0.9627636278613909 1.3117164843927334 0.8910047157971075 0.9735830362334211 2.3368179572829137 1.7401326519773783 1.2487846667237408 1.0 13.352597057753492 NQTYSFS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 NQTYSFSPSK 10 0 Q86YS7-3;Q86YS7;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 NQT(0.014)YS(0.203)FS(0.781)PS(0.002)K;NQT(0.054)YS(0.411)FS(0.534)PS(0.001)K 154.67 0.00054837 38892000.0 5918.799999999999 6985.6 7234.700000000001 7512.299999999999 6016.299999999999 5671.2 5940.4 5532.5 2826.3 5571.7 True False 6056.696524020031 6167.722704482664 6252.267477362486 6200.417828335969 5472.126727264033 5614.152877037604 5492.31084535652 5385.760127907297 4796.024675215268 6286.881967953906 0.9633863900885689 0.9810463654195145 0.9944941720287004 0.9862468963058842 0.8704039228280537 0.8929947954573666 0.8736144361151443 0.8566663340206014 0.7628622104983078 1.0 12.6181289623886 -6.263039883287281 23.084731695029244 0.8696450215918586 0.9822187258498306 0.4701730350738087 0.05444990746184703 40.788532541160414 588312.7948607048 0.016039069800844734 0.019183728748545594 5.457077439034361e-07 6.263039883287281 0.11257370425797197 NQTYSFS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 NQTYSFSPSK 10 0 Q86YS7-3;Q86YS7;H0YFE9 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 NQTYS(0.078)FS(0.92)PS(0.002)K;NQTYSFS(0.997)PS(0.002)K;NQT(0.002)YS(0.223)FS(0.77)PS(0.006)K 176.87 7.4338e-05 96662000.0 296038.0 241927.0 269304.0 302789.0 263991.0 187145.0 257382.0 254200.0 156872.0 206016.0 True False 279585.39309400914 260482.02298208815 251977.2738360247 261548.6158598405 230826.09047051583 212922.52501683513 269350.77299275744 254939.67991492435 188250.7833699029 200067.78278614834 1.3974533490624867 1.3019688595265553 1.259459520803318 1.3073000171117446 1.1537394339859552 1.0642519352774913 1.3462975859569826 1.2742665328951457 0.9409350208630213 1.0 17.610129341046807 -1.5228787498639171 0.08217568385547 0.802540159631857 2.3183005825489795 0.5033713443740789 0.10424751079310922 173.43395150531157 1.0400036085788114 2.807778341100646 29.785922643647893 0.02999999968337754 1.5228787498639171 1.5157604229171224 NQVALNPQNTVFDAK ddPTM_A459_Selumetinib_30min_R2 2 NQVALNPQNTVFDAK 15 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2 A0A0G2JIW1 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 ; 127.52 0.014535 8065500.0 61738.0 57146.0 63447.0 65101.0 62775.0 50684.0 54449.0 56277.0 40774.0 61780.0 False True 58306.84911679564 61528.914446648756 59364.889095870414 56234.131494511035 54888.64328437956 57665.260936457125 56980.9863886467 56440.756752841124 48929.93932074814 59996.25087628281 0.9718415445163257 1.0255459890906589 0.9894766461038655 0.9372940921003619 0.9148678872878981 0.9611477399707462 0.949742451509948 0.9407380616036591 0.8155499486400524 1.0 15.872584730084133 -5.747871019875762 3.9470413641458593 0.9295842860558862 1.0005289447867256 0.2924720569380047 0.046011152474650034 0.2571640109170434 8.824158856126553 0.01277317773867529 0.021720963644057203 1.7870182185017042e-06 5.747871019875762 0.07094465873083944 NQVAMNPT(ph)NTVFDAK ddPTM_A459_Selumetinib_30min_R2 1 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 NQVAMNPT(0.998)NT(0.002)VFDAK 176.08 7.158e-09 0.0 17898.0 13905.0 12445.0 13813.0 13467.0 12010.0 15132.0 14501.0 10152.0 15229.0 True False 16903.30081137078 14971.468788378017 11644.302249091494 11931.645571245921 11775.15506349246 13664.26848407486 15835.667983489157 14543.195509230221 12182.683670580154 14789.299200306097 1.1429412971116935 1.0123176619530525 0.7873464517406267 0.8067755888662371 0.7961942553200051 0.9239294099744799 1.0707517488835037 0.9833593405784378 0.8237498954871375 1.0 13.852266070647888 -9.628573238551022 15.6968035008173 1.0000003278415237 0.9241991590312313 0.032141535122969356 0.11814521708926486 0.0 0.0 0.12404185053004517 0.0300845677489679 2.3519428330182493e-10 9.628573238551022 -0.07580116881029242 NQVAMNPTNTVFDAK ddPTM_A459_Selumetinib_30min_R2 3 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ;; 234.52 2.7212e-13 14558800.0 85987.9 74882.1 78027.6 89324.0 87529.0 67823.1 75297.6 74340.8 54562.9 77442.4 False True 81209.03675483675 80625.31628609885 73007.38916602735 77157.91710750523 76532.82450081174 77165.11638819794 78799.08759936385 74557.11942021802 65477.004614804726 75206.43669248038 1.0798149776315165 1.0720534017025207 0.9707598495133476 1.0259483164054757 1.0176366261541545 1.0260440433273899 1.0477705242381559 0.9913662008091486 0.8706303275947063 1.0 16.198568522661425 -8.02065845930433 6.894858555903673 0.9333061401012112 1.0312945264643845 0.48409342297608215 0.04071496575795825 0.14276005307792614 29.157888119823532 0.025449566308852242 0.010324759156339756 9.535457629035369e-09 8.02065845930433 0.09798838636317331 NQVDSETHCHAER ddPTM_A459_Selumetinib_30min_R1 1 NQVDSETHCHAER 13 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 134.18 0.00070365 806380.0 247.03 545.59 405.0 588.49 631.57 684.46 589.01 476.84 61.18 325.06 False True 252.78531836329458 481.7120691620905 350.00322450575806 485.7212688254508 574.4446050127402 677.5749538399564 544.5805014853286 464.1926542053888 103.81799158959424 366.78461735253086 0.689192802544205 1.313337709305018 0.9542472828661634 1.3242683739885561 1.5661632953941995 1.847337433970719 1.4847419322438793 1.2655728518713623 0.28304892484029875 1.0 8.518789324523995 -5.7676886965579275 24.612843222392694 1.3115506234853218 1.018367101504968 0.06606558365586768 0.416955676256825 319.5848994372646 1258687.1528638117 0.12248132295957836 0.18698016969742834 1.7073057518089437e-06 5.7676886965579275 -0.2931835219803538 NQVDSETHCHAER ddPTM_A459_Selumetinib_30min_R2 2 NQVDSETHCHAER 13 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 ; 73.219 0.029617 2313510.0 9098.8 8651.9 12866.0 11174.8 13988.5 9464.7 8659.8 8651.4 7762.0 13115.8 False True 8593.125121382294 9315.472909756767 12038.215567441632 9652.772962394769 12231.139571223312 10768.376513007765 9062.497859068164 8676.574141683626 9314.616888400631 12737.11277505908 0.6746525113767343 0.7313645623047063 0.9451290712455668 0.7578462350821099 0.9602756752828215 0.8454330822989683 0.7115033068415403 0.681204154733833 0.7312973554446232 1.0 13.636750666784998 -10.330943447535837 18.895095578885687 0.9999999999994036 0.7867315868124156 0.3093598790908261 0.09745925118934802 0.0 0.0 0.10080724807394528 0.024449348919806997 4.6672015119053804e-11 10.330943447535837 -0.21326841318698797 NQVVSS(ph)TNGELNTDDPTAGR ddPTM_A459_Selumetinib_30min_R1 1 NQVVSSTNGELNTDDPTAGR 20 0 H0YBN6;Q9Y6M4-6;Q9Y6M4-5;Q9Y6M4-3;Q9Y6M4-4 H0YBN6 CSNK1G3 Casein kinase I isoform gamma-3 1 NQVVS(0.063)S(0.933)T(0.004)NGELNTDDPTAGR 384.32 5.280799999999994e-267 11647000.0 2913.1 2449.8 3748.8 1860.2 3354.3 2541.1 3137.7 3684.9 1208.3 2900.6 True False 2980.969562094133 2162.976277118878 3239.7335506844092 1535.350990278686 3050.904157249765 2515.5388411341987 2901.0207628232383 3587.1644817579036 2050.396849259671 3272.9202642366063 0.9107981012147971 0.6608704467242444 0.9898602132429469 0.469107361720833 0.9321657452481124 0.7685915445669853 0.8863707419098669 1.0960134045901033 0.6264732054931124 1.0 11.67636274014844 -7.330618183277059 5.192472575991363 0.9126195679145074 0.7839117801396762 0.08824971872928977 0.1784438642487635 0.5237264160261933 27.11724254707142 0.07167862589235915 0.0479344575025726 4.670698315399857e-08 7.330618183277059 -0.12870778777483116 NQVVSS(ph)TNGELNTDDPTAGR ddPTM_A459_Selumetinib_30min_R2 1 NQVVSSTNGELNTDDPTAGR 20 0 H0YBN6;Q9Y6M4-6;Q9Y6M4-5;Q9Y6M4-3;Q9Y6M4-4 H0YBN6 CSNK1G3 Casein kinase I isoform gamma-3 1 NQVVS(0.222)S(0.667)T(0.111)NGELNTDDPTAGR 107.63 0.00044339 21146000.0 67787.0 25554.0 59051.0 65734.0 56402.0 42951.0 81090.0 67908.0 48995.0 45182.0 True False 64019.669912861245 27513.909630939368 55251.722949867515 56780.91580252517 49316.27651972242 48867.11037964188 84860.84567678669 68105.60103722548 58795.36903468035 43877.478263065874 1.4590553615919668 0.6270622360287137 1.259227401780197 1.2940788315613123 1.123954212319323 1.1137173856405522 1.93404108522387 1.552176736978838 1.3399897022835905 1.0 15.421192992758375 NQYDNDVTVWS(ph)PQGR ddPTM_A459_Selumetinib_30min_R1 1 NQYDNDVTVWSPQGR 15 0 B4DEV8;P25786;P25786-2 B4DEV8 PSMA1 Proteasome subunit alpha type;Proteasome subunit alpha type-1 1 NQYDNDVTVWS(1)PQGR 228.49 9.151399999999999e-14 6413000.0 1085.2 1041.8 1126.5 1129.6 737.04 903.08 1215.8 1034.1 602.07 714.35 True False 1110.483048568382 919.8255716803201 973.527487421571 932.3365652181501 670.3748621349806 893.9958351310339 1124.091227153804 1006.672308769803 1021.668816547025 806.0437808582428 1.3776956971071528 1.1411608072962576 1.2077848753885283 1.1566822886784585 0.8316854221258212 1.1091157284026723 1.3945783763220867 1.2489052489158083 1.267510327366081 1.0 9.65471439169383 -4.758937235703842 24.79954906966496 1.1569069003434629 1.3776960206893885 0.1777859287629956 0.14584028649163447 123.51394977890457 1223901.629534367 0.03911846138016979 0.2568076671570275 1.7420586177427306e-05 4.758937235703842 0.22078912034592557 NQYDNDVTVWS(ph)PQGR ddPTM_A459_Selumetinib_30min_R2 2 NQYDNDVTVWSPQGR 15 0 B4DEV8;P25786;P25786-2 B4DEV8 PSMA1 Proteasome subunit alpha type;Proteasome subunit alpha type-1 1 NQYDNDVTVWS(1)PQGR;NQYDNDVTVWS(1)PQGR 185.74 2.162e-05 10899500.0 25132.0 29690.0 32272.0 34335.0 33694.0 26470.0 27020.0 24502.1 20659.6 28931.0 True False 23735.26405136722 31967.127531603277 30195.65465509688 29658.513768821304 29461.058491818152 30116.00222926408 28276.483539114273 24573.397054458983 24792.097277454475 28095.686858234658 0.8448009892454568 1.1377948399305258 1.0747434226277597 1.0556251540840544 1.0485971971595816 1.0719083815684427 1.0064350333128314 0.8746323654036842 0.8824164862938055 1.0 14.778061050001277 -7.613423991314986 4.761831432236373 0.9100270525659342 1.0458020086868438 0.3163764364783128 0.07794496281727245 0.2179202171832579 8.564928733636535 0.03679446990066265 0.020597698497293124 2.4354320033547316e-08 7.613423991314986 0.13577495612090962 NREEEWDPEYT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 NREEEWDPEYTPK 13 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 NREEEWDPEYT(1)PK;NREEEWDPEY(0.001)T(0.999)PK 146.27 0.0011718 40989000.0 12016.3 13560.2 15326.599999999999 16848.6 10552.0 12784.6 11263.7 10621.599999999999 8646.2 12055.6 True False 12296.256410350396 11972.565480034042 13245.331902987533 13906.308297392468 9597.573463106906 12655.998531488036 10414.070040543103 10339.880664180777 14671.969906537273 13603.053691488249 0.9039335350153365 0.8801380742564854 0.9737028319806934 1.0222931271743765 0.7055455106460643 0.9303792235567807 0.7655685463521645 0.7601146697414481 1.078579136662371 1.0 13.731642931836713 -2.4731794196985706 12.612989968779871 0.8916251652740347 1.2772257224373185 0.0 0.11836553450805307 0.0 0.0 0.026586042896846403 0.0 0.0033637257535906323 2.4731794196985706 0.3856005571632838 NREEEWDPEYT(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 NREEEWDPEYTPK 13 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 NREEEWDPEYT(1)PK;NREEEWDPEYT(1)PK;NREEEWDPEYT(1)PK;NREEEWDPEYT(1)PK 165.24 0.00050175 128997000.0 460410.0 464179.0 400331.0 452072.0 390717.0 361467.0 394557.0 346733.0 275492.0 431951.0 True False 434822.2553672599 499780.0367292729 374574.13930743595 390499.0137323021 341631.63740570226 411255.7981792749 412904.68229986366 347741.9356252614 330598.0978896243 419479.45228652115 1.0365758155664297 1.191429124847582 0.8929499103369357 0.9309133298514364 0.8144180496649316 0.980395573460344 0.9843263598471406 0.8289844323238503 0.7881151176477952 1.0 18.678240618092694 -5.273390310495495 24.829432803848256 0.899976635732987 1.1140024674132063 0.5378168496545561 0.07839397531435421 441.397757405665 917054.9394305113 0.020609294845034126 0.04342897946069241 5.328557904054319e-06 5.273390310495495 0.21402583168021927 NREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELR ddPTM_A459_Selumetinib_30min_R1 2 NREELDKYWSQQIEESTTVVTTQSAEVGAAETTLTELR 38 2 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 102.4 9.1465e-15 27859000.0 2449.81 3400.1000000000004 2973.0 2104.41 3014.9 2001.51 2491.59 2744.2 1840.59 2064.44 False True 2506.885806499544 3002.014711336393 2569.2829295200436 1736.9142981681382 2742.2028273238275 1981.376626625678 2303.6473603093837 2671.4149015821417 3123.3467986252253 2329.4309833484863 1.0761794723344718 1.2887330566115711 1.102965895055958 0.7456388751519809 1.1771985720658675 0.8505839583955002 0.9889313642587344 1.1468100667838048 1.340819634044495 1.0 11.18576187140556 -10.453999103819484 8.196788370048507 1.0000121377957938 1.0721895433072945 0.01710918237660075 0.17299934666684555 4.91999827090557e-10 0.0 0.1725827173151707 0.0418574572145037 3.515611659852292e-11 10.453999103819484 0.07217740551150076 NRENS(ph)PSSQSAGLSSINK ddPTM_A459_Selumetinib_30min_R1 2 NRENSPSSQSAGLSSINK 18 1 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2 H3BSS6 ZNF106 Zinc finger protein 106 1 NRENS(0.995)PS(0.005)SQSAGLSSINK;NRENS(0.872)PS(0.098)S(0.029)QS(0.001)AGLSSINK 168.89 5.0729e-07 12885000.0 4923.6 5870.8 5579.3 5601.4 4821.7 5447.7 5217.3 4897.6 3105.0 4803.8 True False 5038.3103003421365 5183.444006739124 4821.661704901176 4623.220641300415 4385.578086340276 5392.901084115846 4823.754860527674 4767.699738353142 5268.958219772641 5420.414522974491 0.9295064572990126 0.9562818461150961 0.889537448559424 0.8529275061353407 0.8090853693480363 0.9949241079732871 0.8899236101006911 0.8795821275559628 0.9720581696178585 1.0 12.404187469704711 -8.405043515397054 4.1932447792570375 0.9986861769531946 0.9000976363143516 0.3324780170043963 0.049244600348347704 0.262477303979489 7.194855151142707 0.04942635875519434 0.012978575672100614 3.9351064453835325e-09 8.405043515397054 -0.09858854063884304 NRENS(ph)PSSQSAGLSSINK ddPTM_A459_Selumetinib_30min_R2 1 NRENSPSSQSAGLSSINK 18 1 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2 H3BSS6 ZNF106 Zinc finger protein 106 1 NRENS(0.998)PS(0.002)SQSAGLSSINK 119.62 0.0046106 6901200.0 33299.0 31713.0 31960.0 37338.0 36793.0 27471.0 29941.0 25387.0 23537.0 34468.0 True False 31448.374886458572 34145.28512663304 29903.728395416932 32252.499988357384 32170.734406406642 31254.88089309079 31333.31582696596 25460.87196695589 28245.05767872785 33472.81928138095 0.9395197524921821 1.0200899075634822 0.8933734605393905 0.9635429784756027 0.9611002328776476 0.9337391221920803 0.9360823647261444 0.7606431879228751 0.8438206964669687 1.0 15.030702448111194 -7.55310890763311 24.304001654628642 0.8510115579780007 0.951751030724963 0.2530001455680375 0.06260538321132468 161.7277734591342 130021.17026685098 0.0278222098842757 0.01606344792606834 2.798279509628686e-08 7.55310890763311 0.10073947274696238 NRENS(ph)SPCQGNGEQAGR ddPTM_A459_Selumetinib_30min_R2 2 NRENSSPCQGNGEQAGR 17 1 Q5T5X7 Q5T5X7 BEND3 BEN domain-containing protein 3 1 NRENS(0.815)S(0.185)PCQGNGEQAGR;NRENS(0.858)S(0.142)PCQGNGEQAGR 135.49 0.00028398 7891000.0 5432.1 3314.28 5868.5 5874.5 6257.4 2729.7 2157.0 2833.17 1810.5 3142.3 True False 5130.205628419218 3568.47461891014 5490.927099139683 5074.382965922262 5471.289470134236 3105.691397250554 2257.3047740144134 2841.4140556434595 2172.6505895966684 3051.5736343241074 1.681167241293034 1.169388337470192 1.7993755868702372 1.6628741672314868 1.7929403402209139 1.0177343788521862 0.7397182714597623 0.9311307528952366 0.7119771140891669 1.0 11.575337687654919 -6.878251761885412 4.947619031977244 0.8455868688281711 1.6061984110011374 0.8045664098947303 0.18373906460282638 0.0928608546788012 3.6334419752059723 0.06670924692258973 0.0588222449212792 1.3235740326993593e-07 6.878251761885412 0.7606115421729662 NREPVQLETLSIR ddPTM_A459_Selumetinib_30min_R2 2 NREPVQLETLSIR 13 1 J3QLI9;P62314 J3QLI9 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 ; 151.7 0.0012921 8839900.0 27427.0 25123.0 30757.0 32150.0 27493.0 19728.8 20532.4 22211.0 18485.3 32491.0 False True 25902.717138980133 27049.85331682281 28778.128105689564 27771.114538156566 24039.08354946153 22446.263119784853 21487.197284178754 22275.63033277102 22182.87652243651 31552.900408243826 0.8209298290756348 0.8572857951833643 0.9120596754449459 0.8801445882579089 0.7618660483960086 0.7113850970708328 0.6809896081237842 0.7059772649918125 0.703037636332183 1.0 14.945485006382137 -6.3341511027873185 4.36992334934385 0.7372529435283947 0.8702083341931555 0.23644041457046028 0.08924044441178788 0.25738600788095123 9.430803569529782 0.026749940293569828 0.03089090892583289 4.6328570207560244e-07 6.3341511027873185 0.1329553906647608 NRHS(ph)PDHPGMGSSQASSSSSLR ddPTM_A459_Selumetinib_30min_R2 6 NRHSPDHPGMGSSQASSSSSLR 22 1 J3KR33;A0JLT2 J3KR33 MED19 Mediator of RNA polymerase II transcription subunit 19 1 NRHS(1)PDHPGMGSSQASSSSSLR;NRHS(1)PDHPGMGSSQASSSSSLR;NRHS(1)PDHPGMGSSQASSSSSLR;NRHS(1)PDHPGMGSSQASSSSSLR;NRHS(1)PDHPGMGSSQASSSSSLR;NRHS(1)PDHPGMGSSQASSSSSLR 102.15 4.573e-05 55670300.0 21496.79 20629.519999999997 34616.0 48098.1 59812.8 35435.7 32485.6 35902.22 35868.7 42760.3 True False 20302.084470268597 22211.737849638266 32388.844247051096 41547.05580614953 52298.58133078354 40316.64602174286 33996.24476899522 36006.68951626751 43043.44225521458 41525.699034398094 0.48890409896414333 0.5348913652540568 0.7799710781562419 1.0005143025222465 1.2594268741258674 0.9708842225231727 0.8186796504216388 0.8670941213160824 1.036549492389261 1.0 15.34171683394953 -5.441150461668939 2.4603052626367363 0.9898942870177254 0.49911472627819164 0.7522340350697291 0.11034800227476041 0.16109220494782917 1.8822012159625696 0.03523223739501848 0.0903100986626897 3.621175207787329e-06 5.441150461668939 -0.49077956073953377 NRNEQESAVHPR ddPTM_A459_Selumetinib_30min_R2 2 NRNEQESAVHPR 12 1 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 0 ; 132.5 0.0014929 1594360.0 1247.7 3069.06 4091.5 2097.1 3948.38 2492.91 2610.89 2114.1 2555.25 3481.96 False True 1178.3578289388374 3304.4470334167177 3828.257344488376 1811.471362300719 3452.349205434942 2836.2857241161573 2732.301558380386 2120.2516809919052 3066.3713996503093 3381.4267675814435 0.3484794762483219 0.9772345404896096 1.1321426154163106 0.5357121377484005 1.020974116172927 0.8387837203243065 0.808032155117367 0.6270287150144048 0.906827682636322 1.0 11.723416393948234 -13.486579956248477 0.020600262816591813 1.9464232313475605 4.637194898999297e-06 0.074366535254909 0.22426765701884874 11028.092627291071 20.357087392670557 1246.2222946187383 737.0811096149449 3.261519983051875e-14 13.486579956248477 -1.9464185941526615 NRPDYVS(ph)EEEEDDEDFETAVK ddPTM_A459_Selumetinib_30min_R1 3 NRPDYVSEEEEDDEDFETAVK 21 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NRPDYVS(1)EEEEDDEDFETAVK;NRPDY(0.074)VS(0.926)EEEEDDEDFETAVK;NRPDY(0.088)VS(0.912)EEEEDDEDFETAVK 138.54 1.4297e-05 135366100.0 3014.87 3729.9700000000003 3607.2 3777.6800000000003 3901.49 3157.35 3343.8700000000003 3342.21 1725.92 3133.9 True False 3085.1106050841845 3293.2633783839924 3117.362052931283 3117.979103836138 3548.6009183640067 3125.589925644427 3091.6391937348176 3253.5637337719004 2928.760183790658 3536.1665917710466 0.8724449273016416 0.9313088885709428 0.8815653821812703 0.8817398793065729 1.0035163294121652 0.8838921596391794 0.8742911606396935 0.9200821424372974 0.8282302622863206 1.0 11.787970527564655 -4.789884960082868 0.005882859263174948 1.787320737424569 5.386724716425196e-07 0.09849371117839589 0.051138848551421534 65315.97785648907 60.230049471097054 8764.565280347864 9545.98199819034 1.6222397542386144e-05 4.789884960082868 -1.7873201987520972 NRPDYVS(ph)EEEEDDEDFETAVK ddPTM_A459_Selumetinib_30min_R2 4 NRPDYVSEEEEDDEDFETAVK 21 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NRPDY(0.026)VS(0.974)EEEEDDEDFETAVK;NRPDY(0.03)VS(0.97)EEEEDDEDFETAVK;NRPDY(0.015)VS(0.985)EEEEDDEDFETAVK;NRPDY(0.028)VS(0.972)EEEEDDEDFET(0.001)AVK 80.171 0.0011212 103090800.0 214715.0 185937.0 217238.0 230606.0 220325.0 176451.0 180195.0 192273.0 147467.0 194177.0 True False 202781.99987224682 200197.77001831337 203261.14359085023 199197.064982461 192645.8037695088 200755.52358730172 188574.42454961865 192832.48259749144 176964.52057224582 188570.60547756506 1.075363784078068 1.0616594750348385 1.07790470882819 1.0563526827417447 1.021610994362685 1.0646172720232707 1.0000202527432307 1.0226009621655132 0.9384523113985543 1.0 17.524745279628945 -7.354741924670344 0.8332730133560635 0.9751139367456391 1.0671878738211433 0.6804385364564554 0.02366041293594681 0.3556597671597085 0.4723123644885445 0.018599299445310063 0.01035335646008712 4.418329243351292e-08 7.354741924670344 0.09207393707550426 NRPDYVS(ph)EEEEDDEDFETAVKK ddPTM_A459_Selumetinib_30min_R1 1 NRPDYVSEEEEDDEDFETAVKK 22 2 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NRPDY(0.198)VS(0.802)EEEEDDEDFETAVKK 45.43600000000001 0.033726 15321000.0 1332.0 1224.5 1777.4 2001.8 1425.9 2184.6 1776.3 1623.1 1047.3 1634.4 True False 1363.0330083791775 1081.1349707453946 1536.038842559344 1652.2232084398854 1296.9275967630924 2162.624907458095 1642.3122608926647 1580.0501154281656 1777.191608234424 1844.1911604041602 0.7390952942646491 0.5862380180308752 0.832906520505562 0.8959066955281336 0.7032500884988879 1.1726685139213817 0.8905325522397293 0.8567713311682357 0.96366995265553 1.0 10.848772491336733 -5.680279377755684 0.9611675018333066 0.9460039679292409 0.6429783606300506 0.4383997059909317 0.11730940235436015 0.6940539784608716 1.1475230124577465 0.04632003294903084 0.1635943400809585 2.087952537547773e-06 5.680279377755684 -0.30302560729919026 NRPDYVS(ph)EEEEDDEDFETAVKK ddPTM_A459_Selumetinib_30min_R2 2 NRPDYVSEEEEDDEDFETAVKK 22 2 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NRPDY(0.268)VS(0.73)EEEEDDEDFET(0.002)AVKK;NRPDY(0.261)VS(0.739)EEEEDDEDFETAVKK 70.334 0.0016230999999999995 9972500.0 32907.0 34624.0 31386.0 34722.0 33973.0 27228.0 22206.7 31411.0 20680.9 31775.0 True False 31078.16067715822 37279.54946629277 29366.65893049299 29992.80370120907 29705.00801752652 30978.409848825188 23239.35555174125 31502.400809629013 24817.6578726262 30857.573188635255 1.007148568916113 1.208116699210251 0.951684008038216 0.9719754537357891 0.962648871832435 1.003915948264993 0.7531167603387627 1.0208968999944315 0.8042647333577893 1.0 14.913336984348817 -5.386835017192343 6.621019650993893 0.9313163952217433 1.1065759157421038 0.3543445171649102 0.09425406592973747 0.2317462195344945 11.382278627071864 0.0234119223454346 0.04924441669902035 4.1035996377647406e-06 5.386835017192343 0.17525952052036053 NRPEDYQGGR ddPTM_A459_Selumetinib_30min_R2 1 NRPEDYQGGR 10 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 112.3 0.023461000000000003 31368000.0 4822.4 5978.8 4685.2 5378.3 6860.6 4607.7 3820.5 3654.8 4096.1 4172.5 False True 4554.390313596739 6437.354735127975 4383.75933286006 4645.766261915006 5998.710093457816 5242.368850463926 3998.1608201771296 3665.4348629152896 4915.434454596472 4052.0290835430533 1.1239776960372718 1.588674365954752 1.0818676871457558 1.1465283605153187 1.480421282715129 1.2937638754260992 0.9867058547075329 0.904592436861354 1.213079756648357 1.0 11.984428813819093 -7.257322197632421 23.550846437083102 1.0181438680698012 1.2928723635042785 0.3747176859890151 0.16411905823723 165.50055827218773 946692.0140895271 0.06372247349315407 0.04745173897385825 5.5293973794919775e-08 7.257322197632421 0.2747284954344773 NRPEPHS(ph)DENGSTTPK ddPTM_A459_Selumetinib_30min_R2 1 NRPEPHSDENGSTTPK 16 1 Q03701;C9J9W7 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 NRPEPHS(0.429)DENGS(0.429)T(0.112)T(0.03)PK 89.507 0.0072045 1392900.0 2206.8 3374.5 2883.9 2415.6 2384.7 882.26 2844.6 2962.6 490.65 2039.5 True False 2084.1548905203394 3633.3132992723204 2698.353013752907 2086.591112857573 2085.1126665115085 1003.7833066411223 2976.8795364679672 2971.2206755151688 588.7937099064376 1980.6143357426156 1.0522769894720074 1.83443754480856 1.3623818453990846 1.0535070231505834 1.0527605646809135 0.5068040196047363 1.5030081741541117 1.5001510500534336 0.29727832384171554 1.0 10.951732271361657 -5.720441455104189 3.806328518403424 1.0091484232344787 1.4755055804793011 0.19811569527873407 0.3945246510162551 0.35444880639302045 10.6980071445341 0.11070050815167816 0.1933235225083613 1.9035248241922573e-06 5.720441455104189 0.4663571572448224 NRPEPHSDENGS(ph)TTPK ddPTM_A459_Selumetinib_30min_R1 1 NRPEPHSDENGSTTPK 16 1 Q03701;C9J9W7 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 NRPEPHS(0.003)DENGS(0.687)T(0.212)T(0.098)PK 75.215 0.017161000000000003 2152200.0 547.59 527.05 913.28 727.51 783.53 568.59 485.34 646.35 344.61 372.07 True False 560.3477815753413 465.34274098110217 789.2615922879473 600.4640355540515 712.6598498434571 562.8705008384139 448.73041305052413 629.2066983593094 584.7780006814329 419.82880876870763 1.3347054081847167 1.1084106932677626 1.8799605358258487 1.430259246179696 1.6975010646210231 1.3407143318468908 1.0688414031580644 1.498722062939593 1.3928963150396836 1.0 8.713657357933398 -6.986724697700225 24.866742154518032 1.2706897742021308 1.4904678719801359 0.1990508265406704 0.2343866190042015 413.7006229748734 774923.6077325563 0.08394895462970839 0.07399730056624663 1.0310394964546556e-07 6.986724697700225 0.21977809777800505 NRPEPHSDENGSTT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 NRPEPHSDENGSTTPK 16 1 Q03701;C9J9W7 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 NRPEPHSDENGS(0.005)T(0.022)T(0.973)PK 110.64 0.0038212 2776200.0 589.97 542.48 739.61 871.54 882.77 604.08 756.84 703.81 376.18 553.7 True False 603.7151531182159 478.96618940789 639.1750243869226 719.3418998320001 802.923609365702 598.0035036607555 699.7509494646202 685.1426725029248 638.3499848998623 624.7727884947282 0.9662955305283915 0.7666246005397713 1.0230519576995245 1.151365605350896 1.2851449745437769 0.9571535679419263 1.1200086853182862 1.0966269420178278 1.0217314144520375 1.0 9.287187809133902 -5.463366063109604 5.470449205626834 1.0976771544928785 0.8690091989906813 0.4531684507140882 0.09679654979276493 0.17399183982696495 10.768015801143552 0.02541569013008395 0.053077379194284686 3.4405980343779736e-06 5.463366063109604 -0.2286679555021972 NRPLS(ph)DEELDAMFPEGYK ddPTM_A459_Selumetinib_30min_R1 1 NRPLSDEELDAMFPEGYK 18 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 NRPLS(1)DEELDAMFPEGYK 92.034 0.0028289 3185400.0 1202.0 1647.2 1881.2 1945.9 1528.2 1638.9 1517.1 1362.2 855.59 1400.3 True False 1230.004261315145 1454.3450582374958 1625.743372691931 1606.0850940669268 1389.974579825624 1622.414154002139 1402.6639255757827 1326.0700309508038 1451.8737401788326 1580.0421450770586 0.7784629448951551 0.9204470037516419 1.0289240560812025 1.016482439453283 0.8797072813256098 1.0268170118481326 0.8877382985928991 0.839262443145864 0.91888292011858 1.0 10.62574732514216 -10.188570459867869 15.054240718504944 1.00000077335819 0.9261632862304628 0.07922015564989593 0.07869940583172598 0.0 0.0 0.07920232425452968 0.019209385217402675 6.477829905332713e-11 10.188570459867869 -0.07383748712772709 NRPTS(ph)ISWDGLDSGK ddPTM_A459_Selumetinib_30min_R1 4 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 NRPT(0.004)S(0.994)IS(0.003)WDGLDSGK;NRPT(0.001)S(0.999)IS(0.001)WDGLDSGK;NRPT(0.001)S(0.987)IS(0.012)WDGLDSGK;NRPT(0.056)S(0.941)IS(0.003)WDGLDSGK 207.55 8.5833e-06 124089000.0 14346.2 14968.6 17018.5 16657.300000000003 14680.5 13553.2 12827.3 12255.9 7724.300000000001 11335.2 True False 14680.438547154185 13216.06935328665 14707.48117592898 13748.415251246723 13352.651367052793 13416.867113321 11859.726433681519 11930.833719226213 13107.572939449208 12790.183334198013 1.1477895322971692 1.0332978822867938 1.1499038592046256 1.074919326174678 1.0439765418647964 1.0489972475568334 0.9272522624418786 0.9328117828714702 1.0248150942764493 1.0 13.642749323475227 -6.786454464093646 1.5349829066080325 0.9676621207081799 1.0992704253325043 0.6159139230950097 0.044286563927728784 0.2495723916239435 1.2216680136552298 0.019479104883259258 0.01731398748680729 1.6351045833470441e-07 6.786454464093646 0.13160830462432438 NRPTS(ph)ISWDGLDSGK ddPTM_A459_Selumetinib_30min_R2 2 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 NRPT(0.088)S(0.897)IS(0.014)WDGLDSGK;NRPT(0.007)S(0.988)IS(0.004)WDGLDSGK 145.79 0.0016896 91048000.0 192822.0 159681.0 197202.0 182797.0 191296.0 155854.0 160760.0 174616.0 122429.0 182280.0 True False 182105.72516762407 171928.01924465937 184514.23801730337 157899.7332575866 167263.6862720619 177321.47379825162 168235.6585398969 175124.10365076506 146918.2209520741 177017.1027796832 1.0287465013720976 0.9712508935288714 1.0423526039003765 0.892002697920719 0.9449012758967111 1.001719444131606 0.9503921140845032 0.9893061229723425 0.8299662498427037 1.0 17.433529229679735 -5.749025155980161 24.99074143457833 0.9462992725403647 1.0098300834471805 0.2730782832058779 0.05216211332840434 327.729478694911 659737.6273212989 0.013754154809976087 0.023608811277441057 1.782275528313751e-06 5.749025155980161 0.06353081090681578 NRPTSISWDGLDSGK ddPTM_A459_Selumetinib_30min_R2 1 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 153.22 0.0005968 4455100.0 54768.0 45634.0 53820.0 53342.0 57731.0 41225.0 47669.0 45167.0 34467.0 48924.0 False True 51724.213813675 49133.981063562955 50357.27979478538 46076.7275799175 50478.315658311716 46903.369546709895 49885.702954331515 45298.42849220061 41361.36308844427 47511.437000182224 1.0886686886249435 1.034150599641398 1.0598980576948713 0.9698028619875415 1.0624455677507316 0.9872016614974202 1.0499725140736151 0.9534215623077634 0.870555927160983 1.0 15.535987221778836 -7.861786623824677 4.826107561584165 0.9285561202757496 1.033352450285025 0.488588667428427 0.044334891594083374 0.16241391696030089 6.219194670601845 0.023986526351955407 0.011150527912110457 1.3747172307881004e-08 7.861786623824677 0.10479633000927546 NRS(ph)AEEGELAESK ddPTM_A459_Selumetinib_30min_R1 2 NRSAEEGELAESK 13 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 NRS(1)AEEGELAESK;NRS(1)AEEGELAESK 148.18 0.00069172 195531000.0 13066.4 13960.7 18346.0 19304.6 14196.900000000001 14196.0 14584.5 14124.900000000001 8869.5 11409.7 True False 13370.82169721148 12326.174753846642 15854.713967364536 15933.414002222293 12912.792901666275 14053.201128936713 13484.379422951692 13750.261767858618 15050.89369735054 12874.246134889474 1.038571234161531 0.9574288563927991 1.2315062024795325 1.2376191844773272 1.002994098945517 1.0915746818644585 1.0473917681602143 1.0680440333197547 1.1690699043388884 1.0 13.652200335783283 NRS(ph)AEEGELAESK ddPTM_A459_Selumetinib_30min_R2 2 NRSAEEGELAESK 13 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 NRS(1)AEEGELAESK;NRS(1)AEEGELAESK 149.6 0.0024444 77571300.0 428665.0 388527.0 442035.0 409864.0 398433.0 312220.0 333108.0 281328.0 221144.0 412927.0 True False 404841.515381956 418325.77158879186 413594.94935131876 354039.81614516326 348378.2845037869 355225.47094903025 348598.1820409796 282146.61790364253 265378.9792796272 401004.7245968085 1.0095679440909462 1.0431941219879612 1.031396699296172 0.8828819074416985 0.868763541013301 0.8858386177524289 0.8693119074631322 0.7035992361120627 0.661785168607311 1.0 18.613259708903122 -6.158694453414651 0.7981076492109349 0.7886069621550764 1.051919477872519 0.47242304728433104 0.09110194718660733 0.5944567082948037 0.7957872217326123 0.04915550969768043 0.09622494830897202 6.939138353265303e-07 6.158694453414651 0.2633125157174425 NRS(ph)NTPILVDGK ddPTM_A459_Selumetinib_30min_R2 4 NRSNTPILVDGK 12 1 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41 P06744-2 GPI Glucose-6-phosphate isomerase 1 NRS(0.994)NT(0.006)PILVDGK;NRS(0.927)NT(0.073)PILVDGK;NRS(0.863)NT(0.137)PILVDGK;NRS(0.777)NT(0.223)PILVDGK 89.35799999999998 0.014237 15517500.0 161906.0 132119.0 151985.0 146518.0 157966.0 117839.0 135239.0 132165.0 99380.0 139025.0 True False 152907.9126810704 142252.10247045755 142206.4505687558 126561.9956423523 138120.89884604237 134070.25261406304 141527.88147099476 132549.5782689063 119258.7769092056 135010.9870196701 1.132559031353447 1.0536335272456934 1.0532953925300714 0.9374199717828383 1.0230345092278985 0.9930321640751355 1.0482693638138887 0.9817688263370359 0.8833264576595568 1.0 17.042717291148556 -1.5228787463120592 0.5392264118912328 0.9793087584641124 7.412005236942747 0.52232548517218 0.04528336971066424 107.88207184714491 1.0219762376155181 0.02340650946589213 800.2921814279936 0.029999999928731192 1.5228787463120592 6.4326964784786345 NRT(ph)LDNSDLQR ddPTM_A459_Selumetinib_30min_R1 1 NRTLDNSDLQR 11 1 E7EUN2 E7EUN2 AGAP1 1 NRT(1)LDNSDLQR 185.2 0.00021598 10791000.0 2612.4 2301.1 2365.2 2896.8 2470.3 2143.3 2127.2 2093.0 1437.5 1706.7 True False 2673.26383715448 2031.6861422476325 2044.0188311136267 2390.928259670625 2246.8618011668873 2121.740347960697 1966.7435913814534 2037.4868409778517 2439.3325091539987 1925.7715696657986 1.3881520940816476 1.054998512933813 1.0614025377206857 1.2415430247968353 1.1667332909877839 1.1017611753033134 1.021275639520821 1.058010655610333 1.2666780149721102 1.0 10.911220869019424 -6.78621555930375 4.802567684345332 1.0877991340377924 1.1724768271925774 0.1480329867234298 0.11067767172236324 0.45113833953910987 25.555404856544403 0.03911378848858648 0.03576568234931515 1.636004299545673e-07 6.78621555930375 0.08467769315478502 NS(ph)EEEEEEK ddPTM_A459_Selumetinib_30min_R2 2 NSEEEEEEK 9 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 NS(1)EEEEEEK;NS(1)EEEEEEK 109.15 0.0116 5824800.0 8427.9 4876.5 5056.5 4419.0 9808.0 10581.0 23424.0 70048.0 12521.0 15204.8 True False 7959.511057556809 5250.511869581121 4731.170295100931 3817.12457679981 8575.8313553675 12038.436705245305 24513.262413775454 70251.82808292934 15025.54986597065 14765.797917185255 0.5390505208183222 0.355586057660337 0.3204141301158221 0.2585112296814809 0.5807902426584391 0.8152919857608443 1.6601380129444654 4.757740047435321 1.0175914603628078 1.0 13.8499716987753 -7.337289979471462 3.330092603364967 2.518459841755187 0.44141331826714947 0.3857871443973452 0.9986050436068519 0.21455098987351784 4.638674597718611 0.4276209860979988 0.2786474724519613 4.599493617332157e-08 7.337289979471462 -2.0770465234880375 NS(ph)FTPLSSSNTIR ddPTM_A459_Selumetinib_30min_R1 1 NSFTPLSSSNTIR 13 0 O60825 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 NS(0.95)FT(0.046)PLS(0.002)S(0.001)SNTIR 111.81 0.0051252 7729100.0 1204.0 1233.1 1463.6 1475.6 1444.6 1352.0 1336.5 1144.2 614.04 863.5 True False 1232.0508574238213 1088.728078747363 1264.8511589793256 1217.9141604425486 1313.9361850648447 1338.400107517781 1235.6867289776771 1113.8520991146002 1041.9810322928158 974.3386362022717 1.2644996427792778 1.1174021416116195 1.2981638128499133 1.2499906246042682 1.3485416017025038 1.373649835681904 1.2682312730552028 1.1431878586444206 1.0694239082565762 1.0 9.928279465019793 -8.058441037769562 1.994107501135535 1.0202244715009392 1.2754271477826067 0.6880476335949959 0.06573048642259713 0.21811649262506574 1.557812458167502 0.06333109819334726 0.020383148412644967 8.740956566152332e-09 8.058441037769562 0.2552026762816675 NS(ph)FTPLSSSNTIR ddPTM_A459_Selumetinib_30min_R2 1 NSFTPLSSSNTIR 13 0 O60825 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 NS(0.891)FT(0.106)PLS(0.001)S(0.001)S(0.001)NTIR 162.64 0.00036328 7377200.0 25898.0 23249.0 20592.0 21769.0 26697.0 22723.0 19976.0 19111.0 14883.0 24188.0 True False 24458.692837908155 25032.123542682526 19267.133138874393 18804.02464638041 23343.084185791828 25852.886991143478 20904.923581693067 19166.609846003637 17860.01586576482 23489.629592028632 1.0412549394226456 1.0656670189119266 0.8202399728522253 0.8005245281842028 0.9937612721536258 1.1006085425849725 0.8899639519555173 0.8159604974149085 0.7603362069117403 1.0 14.519736343220686 -7.514393683402633 23.84281055384656 0.8434814030004629 0.964038921035269 0.18177060059627825 0.10742855892873676 383.74097370535327 1078319.1287797606 0.05164749502979028 0.0317315650752499 3.0591890535470054e-08 7.514393683402633 0.12055751803480608 NS(ph)GIWESPELDR ddPTM_A459_Selumetinib_30min_R1 2 NSGIWESPELDR 12 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 NS(0.744)GIWES(0.256)PELDR;NS(0.998)GIWES(0.002)PELDR 207.66 9.0128e-06 21289000.0 2596.2 2666.3999999999996 2023.59 2036.69 2342.1 2193.85 2609.7 2702.5 1280.21 2002.4700000000003 True False 2656.6864086741916 2354.2166484242707 1748.797592784213 1681.0203249062986 2130.2574685313402 2171.781860856424 2412.848227918476 2630.8209210428327 2172.422867161074 2259.5065302095695 1.1757816908932694 1.0419162843516618 0.7739732412377723 0.7439767499810606 0.9427976595994872 0.9611752972694401 1.067865127034921 1.164334285326816 0.9614589903219184 1.0 11.14179201121619 -7.126195440470213 3.273033397808636 1.0620755154178547 0.9235926467560097 0.1474495490999127 0.12537976150126753 0.4706629234696611 9.428187940879555 0.0565029687757049 0.042662142005563355 7.478328862814509e-08 7.126195440470213 -0.138482868661845 NS(ph)GIWESPELDR ddPTM_A459_Selumetinib_30min_R2 2 NSGIWESPELDR 12 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 NS(1)GIWESPELDR;NS(0.999)GIWES(0.001)PELDR 140.77 0.0010472 11825500.0 25161.0 23221.0 28811.0 32144.0 34810.0 22565.7 25651.0 28628.0 23585.5 34527.0 True False 23762.652347463405 25001.97603271672 26957.331627044987 27765.93174850712 30436.85659465158 25673.920343970698 26843.82232649222 28711.30274037948 28303.259033931077 33530.11579808053 0.7086958032165139 0.7456573124673785 0.8039737109583198 0.828089348563974 0.907746838034898 0.7656973360479844 0.8005884169367803 0.8562840317426846 0.8441145626926624 1.0 15.033169845115625 -14.522878745267528 0.061368008257141615 1.663819698494128 0.5322654586804437 0.6837238653086279 0.04470535848331552 257.6464530378894 1.1485090817171841 25.720113394588658 4.099502683509666 3.0000000000884848e-15 14.522878745267528 -1.1315542398136844 NS(ph)GVNYLILDDDDR ddPTM_A459_Selumetinib_30min_R1 1 NSGVNYLILDDDDR 14 0 O75815;O75815-3;O75815-2 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 NS(1)GVNYLILDDDDR 139.39 0.000571 14039000.0 294.42 450.67 348.26 416.07 439.16 337.7 402.36 473.92 317.48 345.7 True False 301.27941315840644 397.9053468892009 300.9682048552474 343.4111851012003 399.4380555399952 334.30304460706736 372.00966125810567 461.35010209088597 538.7403721782347 390.07396240315603 0.7723648389712895 1.0200766655579818 0.7715670202672628 0.8803745397040165 1.0240059425631722 0.8570247615285653 0.9536900616648177 1.1827246793111081 1.381123643473097 1.0 8.607603890865905 -7.734215221612019 3.7195999111928906 1.2192393379732753 0.8952609419582005 0.5633246435799945 0.11784980359255003 0.1483305139256567 4.332613184026519 0.0614983481751761 0.03074076295020356 1.844101318646221e-08 7.734215221612019 -0.32397839601507483 NS(ph)IEVAGLSHGLEGLR ddPTM_A459_Selumetinib_30min_R2 2 NSIEVAGLSHGLEGLR 16 0 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 NS(1)IEVAGLSHGLEGLR;NS(1)IEVAGLSHGLEGLR 154.65 7.1161e-05 2865900.0 15124.699999999999 10926.2 14360.3 12887.2 17975.1 13597.7 15953.900000000001 15326.4 13389.2 13685.4 True False 14284.129722971249 11764.204406729668 13436.373932312446 11131.941128340004 15716.907238567128 15470.659747369245 16695.787962053106 15370.997286577896 16067.414125505491 13290.266943060547 1.074781250381855 0.885174425549992 1.010993533077843 0.8376010185523397 1.1825877768974113 1.1640593686831233 1.2562417319067272 1.1565604628132615 1.2089609783116522 1.0 13.698082461858192 -6.279566006631857 24.68459044904011 1.174104646431171 0.9515584769498987 0.5817511251406599 0.08652403976139604 435.6613956193088 593276.046796263 0.02499581779626491 0.028400742493133988 5.25332165967283e-07 6.279566006631857 -0.22254616948127237 NS(ph)IQFTDGYEVK ddPTM_A459_Selumetinib_30min_R2 2 NSIQFTDGYEVK 12 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 NS(0.993)IQFT(0.007)DGYEVK;NS(0.54)IQFT(0.009)DGY(0.451)EVK 137.39 0.0013276 8953000.0 48505.0 41311.0 46796.0 57053.0 49104.0 41903.0 58135.0 49112.0 38158.0 45306.0 True False 45809.286280899534 44479.4208641988 43785.19630763241 49282.2829780854 42935.11652467026 47674.75789243871 60838.39269231709 49254.907789070734 45790.66622360102 43997.89806087518 1.0411698808319918 1.0109442228957708 0.995165638300528 1.1201053948054243 0.9758447202469885 1.0835689883747686 1.382756799157576 1.1194832016957263 1.040746677494579 1.0 15.425146982172425 -7.006019306497737 24.959944899457465 1.158197782052792 1.0307659122497332 0.18501818267783054 0.10174147286850282 377.9869025133926 1567382.538128821 0.036537247338725924 0.031190903501406755 9.862356416953305e-08 7.006019306497737 -0.12743186980305876 NS(ph)LESISSIDR ddPTM_A459_Selumetinib_30min_R1 4 NSLESISSIDR 11 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 NS(0.967)LES(0.029)IS(0.004)SIDR;NS(0.999)LES(0.001)ISSIDR;NS(0.995)LES(0.005)ISSIDR;NS(0.993)LES(0.007)ISSIDR 188.09 1.9423e-05 34124600.0 4151.620000000001 5320.87 4183.29 3109.74 3581.33 3936.5899999999997 4325.4400000000005 4654.26 2220.0299999999997 4416.33 True False 4248.344668353727 4697.9000667946475 3615.2221951671395 2566.6822860494794 3257.399333835165 3896.9914787377406 3999.168578368276 4530.813905632861 3767.2287654241095 4983.20897419708 0.8525319107329311 0.9427459476654994 0.7254807522395029 0.5150661550297589 0.6536750416652983 0.7820244944404812 0.8025287719370914 0.9092161153773184 0.7559845041479731 1.0 12.28285936033238 -8.688622113488892 0.6814476475888529 0.9937179168059637 0.7453588456326694 0.2658851042925118 0.11657381106120543 1.465629050560382 1.4665863372446322 0.13501503608262228 0.051872881134437825 2.0482260555417334e-09 8.688622113488892 -0.24835907117329425 NS(ph)LESISSIDR ddPTM_A459_Selumetinib_30min_R2 1 NSLESISSIDR 11 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 NS(0.999)LES(0.001)ISSIDR 116.79 0.0057872 7938400.0 9564.2 4826.9 8040.4 7288.0 5355.8 6175.8 12846.0 11886.0 6954.6 6986.1 True False 9032.660052526113 5197.1077090702565 7523.089417725612 6295.3618274987575 4682.956522540501 7026.460391669398 13443.364453866097 11920.586292166769 8345.714327759722 6784.39314093233 1.3313880644724576 0.7660387010467461 1.1088817026738176 0.9279181935252105 0.6902542976595482 1.0356800152509738 1.9815131839512874 1.7570600707447517 1.2301342440501364 1.0 12.728004058047814 -7.103631512424296 7.859506145393272 1.5534600336896771 0.9504051908041176 0.4078336280703059 0.30137591467893116 0.2516554221221597 17.07166640769413 0.1123648471023701 0.08703756975101218 7.877138609639674e-08 7.103631512424296 -0.6030548428855595 NS(ph)LTGEEGQLAR ddPTM_A459_Selumetinib_30min_R2 2 NSLTGEEGQLAR 12 0 Q9BX95 Q9BX95 SGPP1 Sphingosine-1-phosphate phosphatase 1 1 NS(0.998)LT(0.002)GEEGQLAR;NS(0.999)LT(0.001)GEEGQLAR 134.81 0.0015474 15584200.0 78241.0 40595.0 58209.0 62170.0 53531.0 38575.0 89043.0 64777.0 55907.0 42053.0 True False 73892.678443539 43708.50596650171 54463.89631316722 53702.338750768075 46805.957206788094 43888.35610101479 93183.67593535715 64965.49034559035 67089.96217209662 40838.8206231842 1.80937346661745 1.0702685655346371 1.33363048888459 1.3149826055525526 1.1461143219257501 1.0746724668170111 2.28174258006013 1.590777827426031 1.6427987181884889 1.0 15.317653583041078 NS(ph)NGTTTETEVRKR ddPTM_A459_Selumetinib_30min_R1 1 NSNGTTTETEVRKR 14 2 E7EUE6;Q9NY46-4;Q9NY46-2 E7EUE6 SCN3A 1 NS(0.558)NGT(0.129)T(0.129)T(0.092)ET(0.092)EVRKR 62.861 0.032635000000000004 3824500.0 2652.5 2798.6 3513.4 2763.3 2780.4 2464.0 2253.9 2063.9 1400.1 1979.5 True False 2714.2980891334614 2470.9386109661577 3036.2995777247643 2280.741528565259 2528.9133109194895 2439.2143971329997 2083.886508374701 2009.1586675079743 2375.8674407419226 2233.588106962823 1.2152187239321828 1.106264222693269 1.3593820491162303 1.0211110640567271 1.1322200825819413 1.0920609711025826 0.9329770792916324 0.8995206686697387 1.0636998976380507 1.0 11.125147449520966 -6.641754843048868 1.0572301713443544 0.9676579362239975 1.1992247277174455 0.5069213250830966 0.08997215466682114 0.40665189554706266 0.9748172712776333 0.04620749883714733 0.04726801384399889 2.281629676496811e-07 6.641754843048868 0.23156679149344794 NS(ph)NPVIAELSQAINSGT(ph)LLSKPSPPLPPKR ddPTM_A459_Selumetinib_30min_R2 1 NSNPVIAELSQAINSGTLLSKPSPPLPPKR 30 2 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 2 NS(1)NPVIAELS(0.116)QAINS(0.081)GT(0.737)LLS(0.058)KPS(0.008)PPLPPKR 92.412 6.0246e-07 1879000.0 13562.0 11148.0 12656.0 15515.0 13866.0 14020.0 14257.0 15564.0 9622.9 15280.0 True False 12808.278332987513 12003.015753530259 11841.726738810914 13401.830235132156 12124.029116387215 15951.12773911153 14919.978749709559 15609.288663241094 11547.748886290949 14838.826697792185 0.8631597762977588 0.8088925086857537 0.7980231173245524 0.9031596977358167 0.8170476927391507 1.0749588268649866 1.005468899500622 1.051922027336807 0.7782117226295996 1.0 13.857089402492244 -6.74450632305501 24.99922786147178 0.9868172162353023 0.8378290613045704 0.44791488287527115 0.07988051784466745 221.44264911859307 326927.679313706 0.025983206050276385 0.025919455513959754 1.800916914031379e-07 6.74450632305501 -0.14898815493073192 NS(ph)NPVIAELSQAINSGTLLSKPS(ph)PPLPPKR ddPTM_A459_Selumetinib_30min_R1 2 NSNPVIAELSQAINSGTLLSKPSPPLPPKR 30 2 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 2 NS(0.999)NPVIAELS(0.018)QAINS(0.014)GT(0.013)LLS(0.031)KPS(0.925)PPLPPKR;NS(1)NPVIAELSQAINS(0.006)GT(0.06)LLS(0.237)KPS(0.698)PPLPPKR 77.907 9.255e-05 2757200.0 460.21000000000004 682.77 223.42 443.87 289.305 434.29999999999995 334.21 624.89 331.67 481.27 True False 470.93199758722363 602.8309709888382 193.0807911582134 366.35643697183116 263.1374138309462 429.93133631284945 309.0002706259855 608.3158872712138 562.8197657816396 543.045692466783 0.8672051065316748 1.1100925379786752 0.355551648483104 0.6746328017218192 0.48455851410153994 0.7917037963414976 0.5690133904245754 1.1201928230163123 1.0364132771683225 1.0 9.08492978287223 -7.767248495127782 24.999502390155712 1.0587273798991523 0.691338942488067 0.4064928217605621 0.19870466451335128 148.5423322036062 639236.6573005449 0.1090401448675085 0.05460424326964771 1.7090371563834485e-08 7.767248495127782 -0.3673884374110853 NS(ph)PEDLGLSLTGDSCK ddPTM_A459_Selumetinib_30min_R1 4 NSPEDLGLSLTGDSCK 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 NS(1)PEDLGLSLTGDSCK;NS(0.999)PEDLGLS(0.001)LTGDSCK;NS(0.936)PEDLGLS(0.059)LT(0.005)GDSCK;NS(0.996)PEDLGLS(0.004)LTGDSCK 281.53 1.1622999999999999e-62 108475500.0 16247.3 19483.2 18039.100000000002 17930.899999999998 15899.000000000002 16498.2 17089.9 16720.0 10229.400000000001 14997.399999999998 True False 16625.83047825753 17202.097886506046 15589.489301683503 14799.60491967966 14460.938257196443 16332.24308716706 15800.795083842571 16276.531285785808 17358.544674184297 16922.46237704685 0.9824711148897772 1.0165245165407184 0.9212305487426372 0.874553867512415 0.8545410197992729 0.965122139040454 0.9337172529498026 0.9618299584972241 1.0257694351697266 1.0 14.046651888946064 -8.063679310998644 3.0993875800965287 1.012515427153662 0.9338332581122961 0.31122111843672307 0.045350016286271014 0.3625557692664235 6.535990956097598 0.03995980915603429 0.013692838782338203 8.636160182910603e-09 8.063679310998644 -0.07868216904136593 NS(ph)PEDLGLSLTGDSCK ddPTM_A459_Selumetinib_30min_R2 10 NSPEDLGLSLTGDSCK 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 NS(0.999)PEDLGLS(0.001)LTGDSCK;NS(0.999)PEDLGLS(0.001)LTGDSCK;NS(1)PEDLGLSLTGDSCK;NS(0.999)PEDLGLS(0.001)LTGDSCK;NS(1)PEDLGLSLTGDSCK;NS(1)PEDLGLSLTGDSCK;NS(0.998)PEDLGLS(0.002)LT(0.001)GDSCK;NS(0.999)PEDLGLS(0.001)LTGDSCK;NS(1)PEDLGLSLTGDSCK;NS(0.911)PEDLGLS(0.084)LT(0.005)GDSCK 191.07 1.043e-06 69597000.0 447096.7 401955.39999999997 438051.7 428845.1 423000.69999999995 331756.80000000005 364442.7 359021.6 273350.8 392487.39999999997 True False 422248.85528389766 432784.08668967994 409867.93053663004 370435.65758093965 369859.5703917621 377453.2878116178 381390.0076795096 360066.2934167745 328028.5980594985 381155.2689572666 1.1078132448202842 1.135453506581859 1.075330616989536 0.971875998446374 0.9703645745304629 0.9902874722005643 1.000615861149933 0.9446709064308999 0.8606167217808435 1.0 18.540019293999265 -5.673371385070263 2.7679108938367114 0.9617586598794722 1.1209042800331506 0.7503160444284177 0.03856761776276377 0.13419563091578512 2.069292972891028 0.01167427083001604 0.022352596403367914 2.1214295546878377e-06 5.673371385070263 0.1591456201536784 NS(ph)PGLGSLVSPHGPHMPPAASIPPPPGLGGVK ddPTM_A459_Selumetinib_30min_R2 1 NSPGLGSLVSPHGPHMPPAASIPPPPGLGGVK 32 0 Q8ND24;E9PN76;Q8ND24-2 Q8ND24 RNF214 RING finger protein 214 1 NS(0.527)PGLGS(0.19)LVS(0.155)PHGPHMPPAAS(0.128)IPPPPGLGGVK 49.038 0.0070072 6694900.0 15956.0 8694.4 16754.0 22605.0 22245.0 14234.0 15075.0 14329.0 8616.2 17206.0 True False 15069.229396928822 9361.232523097728 15676.065880375963 19526.160004199977 19450.38422717679 16194.604296612944 15776.017370545804 14370.695017706348 10339.680756742784 16709.21807344321 0.901851261423124 0.5602436021812414 0.9381687288701266 1.1685861012990113 1.1640511328348901 0.9692018037846925 0.9441505461957798 0.8600459312064642 0.6188009942354006 1.0 14.028356601999398 -10.966184165285208 3.257239299193066 1.0013603625781098 0.9111690635786523 0.022202440775455523 0.1862056914956794 97385769.26424184 143154147.30361986 1239542.2849345077 0.05101553392287149 1.0809754597023274e-11 10.966184165285208 -0.09019129899945744 NS(ph)PGSQVASNPR ddPTM_A459_Selumetinib_30min_R1 5 NSPGSQVASNPR 12 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 NS(0.997)PGS(0.003)QVASNPR;NS(1)PGSQVASNPR;NS(0.997)PGS(0.003)QVASNPR;NS(1)PGSQVASNPR;NS(0.998)PGS(0.002)QVASNPR 192.4 0.00010365 539136800.0 13051.57 15342.08 15569.0 15834.18 13283.98 12180.479999999998 15241.8 12683.44 8169.7 13251.26 True False 13355.646187065646 13545.822141260516 13454.81531439541 13069.037707370695 12082.446354477162 12057.95543019097 14092.098754756427 12347.033969580569 13863.384208720305 14952.188299202915 0.8932235148334522 0.905942452716612 0.8998559304602037 0.8740551848231735 0.808072110429566 0.806434161268138 0.9424773466441472 0.8257676884820114 0.9271809538045576 1.0 13.868069022325662 -8.541357798795646 5.702643950308593 0.9999742315810668 0.8703252773341225 0.48513833244834126 0.042234066154771085 0.138098025900466 23.28933806540979 0.04232620398455194 0.010979628278888156 2.875028811272058e-09 8.541357798795646 -0.12964895424694434 NS(ph)PGSQVASNPR ddPTM_A459_Selumetinib_30min_R2 8 NSPGSQVASNPR 12 0 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 NS(0.973)PGS(0.027)QVASNPR;NS(1)PGSQVASNPR;NS(0.995)PGS(0.005)QVASNPR;NS(0.973)PGS(0.027)QVASNPR;NS(1)PGSQVASNPR;NS(1)PGSQVASNPR;NS(0.99)PGS(0.01)QVASNPR;NS(0.995)PGS(0.001)QVAS(0.004)NPR 181.75 0.00010354 848070200.0 184089.0 164227.1 172476.5 178603.4 186405.3 125682.02 143753.69999999998 153404.6 121096.37 166959.41999999998 True False 173858.07034665532 176822.79049664436 161379.54976821438 154277.30881194962 162987.3997294743 142993.57742721622 150438.53189255268 153850.98198850147 145319.02771528077 162138.8677319304 1.0722787989003395 1.090563866456693 0.9953168664963701 0.9515134216122777 1.00523336575254 0.8819204144414792 0.9278375629295607 0.9488840284913574 0.8962627514800557 1.0 17.306870447849576 -5.464783552470144 1.1810048503500714 0.934909896044217 1.1006124767936427 0.6681663520064527 0.037796994582303046 0.3571418840858112 0.8401443933973833 0.012397695579008326 0.054466574419900576 3.4293866076871203e-06 5.464783552470144 0.16570258074942568 NS(ph)PGVPTGAK ddPTM_A459_Selumetinib_30min_R1 1 NSPGVPTGAK 10 0 R4GND7;B7ZC06;Q08379 R4GND7 GOLGA2 Golgin subfamily A member 2 1 NS(1)PGVPTGAK 106.88 0.011631 16526000.0 3848.1 4643.0 4676.7 4757.2 4076.4 3597.5 3994.0 3655.6 2168.2 3535.6 True False 3937.753242900835 4099.395401527859 4041.629827274265 3926.444323703776 3707.690339746873 3561.3124162686527 3692.72936441215 3558.6416129377158 3679.2770409375344 3989.4286996603937 0.9870469030405388 1.0275645236815052 1.013084862907392 0.9842121815682583 0.9293787704646773 0.8926873205107826 0.9256286156277211 0.892017850385608 0.9222566231728213 1.0 11.961966446854309 -6.172901580589947 2.710106920506715 0.9188131749820823 1.0103190881455621 0.6097823848740321 0.02991182724086332 0.16207059111560296 2.3247724301708717 0.008962511158324174 0.011986995764753672 6.715810287481094e-07 6.172901580589947 0.09150591316347989 NS(ph)PLDCGSASPNK ddPTM_A459_Selumetinib_30min_R1 1 NSPLDCGSASPNK 13 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 NS(1)PLDCGSASPNK 174.21 0.00012943 6869000.0 2765.5 2972.5 1767.4 1892.8 2073.6 1887.2 2596.5 2658.4 1314.6 2569.6 True False 2829.9307692737384 2624.478318122241 1527.3967876332758 1562.2580122564755 1886.0432461238147 1868.2164814405019 2400.643914545856 2587.8905962998188 2230.780185414851 2899.4331900235757 0.9760289628369495 0.9051694404108346 0.5267915097643123 0.5388149717096163 0.6504868788194009 0.6443385168758833 0.8279700745670006 0.892550518220003 0.7693849242985014 1.0 11.501555180120821 -7.412445870496265 4.684971332918836 0.8712385541016331 0.6980808841791575 0.24372864131895056 0.14410042876642862 0.38355913012312165 13.243560683043459 0.0695340005051346 0.04543848244290137 3.868602690366705e-08 7.412445870496265 -0.1731576699224756 NS(ph)PLDCGSASPNK ddPTM_A459_Selumetinib_30min_R2 2 NSPLDCGSASPNK 13 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 NS(1)PLDCGSASPNK;NS(0.999)PLDCGS(0.001)ASPNK 189.8 0.00015892 13307300.0 94703.0 67743.0 75385.0 73115.0 81461.0 58267.0 86020.0 82737.0 61513.0 63850.0 True False 89439.7863861464 72938.67027192311 70534.81117298204 63156.61086958995 71227.14090942005 66292.75035483685 90020.10044539643 82977.75097215235 73817.31881682406 62006.48459777689 1.442426335992495 1.1763071353756147 1.1375392691671946 1.0185484837476868 1.14870471002276 1.0691260887448155 1.4517852613212634 1.3382108582741254 1.1904774040273622 1.0 15.920131479046582 -7.225233102391568 24.99293106084731 1.273302889009153 1.1572298186204901 0.04887660859795884 0.15059208277734842 1307.0939474016616 902278.7486855586 0.05761642258087988 0.044627956365957504 5.9534251475277915e-08 7.225233102391568 -0.11607307038866277 NS(ph)PNNISGISNPPGTPR ddPTM_A459_Selumetinib_30min_R2 2 NSPNNISGISNPPGTPR 17 0 Q9NW25;A0A087WVT6;Q9BWW4-2;Q9BWW4-3;Q9BWW4 Q9NW25 SSBP3 Single-stranded DNA-binding protein 3 1 NS(0.888)PNNIS(0.096)GIS(0.013)NPPGT(0.003)PR;NS(0.999)PNNIS(0.001)GISNPPGTPR 83.869 0.012799 11110000.0 62517.0 43918.0 57289.0 62362.0 59542.0 49978.0 60101.0 55636.0 43775.0 52347.0 True False 59042.555415379735 47286.36938137263 53603.088111547 53868.18801954959 52061.8016477663 56862.015844887035 62895.8155878722 55797.89154896435 52531.22317569409 50835.60609616019 1.16144096528908 0.9301820714387893 1.0544398351453086 1.0596546821464663 1.02412080126057 1.1185470226779108 1.237239415792526 1.097614365872171 1.0333549102636148 1.0 15.633551717972063 -6.766505575726994 24.875933315849945 1.1121950690167162 1.0407662009387548 0.07926407468120877 0.0789332637593726 226.40327591449335 1111672.5190709464 0.02715570616428768 0.02467529239570659 1.7119631973752724e-07 6.766505575726994 -0.07142886807796134 NS(ph)PPFLK ddPTM_A459_Selumetinib_30min_R2 1 NSPPFLK 7 0 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 NS(1)PPFLK 102.06 0.019521 12965000.0 176050.0 166360.0 189990.0 179030.0 178630.0 129850.0 168690.0 156880.0 113640.0 166540.0 True False 166265.8457839884 179119.27706828975 177766.25024547134 154645.80515602403 156188.9024275385 147735.65883906075 176534.41925289377 157336.49482711792 136371.17536689615 161731.55747711487 1.0280358909393124 1.1075097517294066 1.0991438716010968 0.9561881896667354 0.9657292915740291 0.913462166219264 1.091527355617493 0.9728249531596896 0.8431945966153993 1.0 17.303241683079527 -5.764047045624234 24.99205397341521 0.965513465556741 1.0811578427564938 0.4169509247716152 0.06222571731708612 65.81456715721245 630781.7889456197 0.01762847157592642 0.027577003621380294 1.721682061000862e-06 5.764047045624234 0.11564437719975285 NS(ph)PQALR ddPTM_A459_Selumetinib_30min_R1 1 NSPQALR 7 0 Q7L7X3;Q7L7X3-3 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 NS(1)PQALR 94.409 0.024453 30313000.0 5704.3 6931.3 4604.1 4389.6 4568.0 5191.3 5691.8 5701.6 3648.5 5368.6 True False 5837.199091364372 6119.7801737260515 3978.88850851101 3623.038762997161 4154.8252065459055 5139.080235323272 5262.462943505531 5550.375046593086 6191.238024103215 6057.712104592378 0.9635979707485878 1.0102461239593443 0.6568302421461392 0.5980869840695334 0.6858736656362581 0.8483533298697561 0.8687212024348326 0.9162493942862229 1.0220423019789289 1.0 12.564557299714084 -7.730149675971247 1.4473083141358944 1.007778723270079 0.7830656479596955 0.3315703622724735 0.12199316587685338 0.5750331440935201 2.2500250476538346 0.11108610537229402 0.044187313516474966 1.8614454944353744e-08 7.730149675971247 -0.22471307531038354 NS(ph)PQALR ddPTM_A459_Selumetinib_30min_R2 2 NSPQALR 7 0 Q7L7X3;Q7L7X3-3 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 NS(1)PQALR;NS(1)PQALR 84.81700000000002 0.037033 183937000.0 336650.0 205670.0 249830.0 243110.0 230700.0 245750.0 343640.0 300210.0 237851.0 217107.0 True False 317940.3407167264 221444.22766671737 233756.2097943377 209997.99861185811 201717.40351583206 279599.83180361334 359619.9409097421 301083.5613975593 285427.8461122106 210838.55679827015 1.5079800656240072 1.0503023309849095 1.108697637396537 0.9960132615249483 0.9567386847028877 1.3261323547719681 1.7056649712027085 1.428028942949156 1.3537744255445048 1.0 17.685779196322336 -6.953292996645827 7.87970355065684 1.4228026119671158 1.1137868331425014 0.22400517483760585 0.21485005715294786 0.28773215178954886 42.08968454516981 0.07488016562294099 0.06583970565164804 1.1135430286387301e-07 6.953292996645827 -0.3090157788246144 NS(ph)PQALRR ddPTM_A459_Selumetinib_30min_R2 2 NSPQALRR 8 1 Q7L7X3;Q7L7X3-3 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 NS(1)PQALRR;NS(1)PQALRR 67.214 0.041102 142223000.0 215440.0 215920.0 173146.0 187751.0 158919.0 140400.0 167115.0 145787.0 98868.0 177252.0 True False 203466.7072746519 232480.3697077734 162005.9748671105 162178.9899114601 138954.17446611403 159738.82557569598 174886.17863209013 146211.2160336628 118644.36260273008 172134.27420399626 1.182023209587671 1.3505757106354137 0.9411604726384547 0.9421655894006434 0.8072429218915431 0.9279896540905593 1.0159869639025672 0.8494021118675524 0.6892547294917263 1.0 17.39317486002534 -5.341630576052357 5.082054431201873 0.8917551648288243 1.2651740740166615 0.6949071243159605 0.09819231939360813 0.10954908547561777 4.93255533361068 0.026250027194150722 0.05716371268550842 4.553752513325896e-06 5.341630576052357 0.37341890918783716 NS(ph)PQPLR ddPTM_A459_Selumetinib_30min_R2 1 NSPQPLR 7 0 Q9UL54-2 Q9UL54-2 1 NS(1)PQPLR 86.882 0.034321 7288700.0 66531.0 39085.0 44272.0 59639.0 44334.0 48042.0 74436.0 77075.0 55168.0 29437.0 True False 62833.47336469485 42082.69382191695 41423.587719708994 51516.0653169866 38764.3665690113 54659.34941814526 77897.42149213587 77299.27548954685 66203.1415227115 28587.077323488786 2.197967726944484 1.4720880118563011 1.449031926242876 1.8020752780718174 1.3560101345918376 1.9120299987167277 2.724917297793534 2.703993647718346 2.315841552235744 1.0 14.803075509261529 -7.0164966948163485 11.230349959253296 2.3269783014838614 1.6410497044447796 0.17670085261583068 0.5044052993052068 0.7970495521301759 536.8430774316056 0.17823074490866742 0.14422440930005576 9.627273397497091e-08 7.0164966948163485 -0.6859285970390818 NS(ph)PSAASTSSNDSK ddPTM_A459_Selumetinib_30min_R1 1 NSPSAASTSSNDSK 14 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 NS(0.919)PS(0.081)AASTSSNDSK 183.75 7.7435e-05 7179600.0 912.45 1196.0 545.33 624.31 746.17 883.39 809.0 922.42 765.25 977.62 True False 933.7083096813675 1055.9717639946844 471.27718128327126 515.2859782501272 678.6790552470135 874.5038986539447 747.9764786703632 897.9544251575679 1298.5733583513734 1103.107049825205 0.8464349038738535 0.9572704336918257 0.427227059565931 0.4671223688868436 0.6152431492071009 0.7927643094951808 0.6780633654629307 0.8140229230697557 1.1771961375436242 1.0 10.107357087157988 -8.070901215267332 3.514992419893391 1.0845867792241457 0.6789717753695669 0.5058570476667354 0.1576778520831164 0.21959858321457992 5.081983590839122 0.13080123127580917 0.04566288293406958 8.493736518110726e-09 8.070901215267332 -0.4056150038545788 NS(ph)PSNLSSSSDTGSVGGTYR ddPTM_A459_Selumetinib_30min_R1 1 NSPSNLSSSSDTGSVGGTYR 20 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 NS(0.741)PS(0.221)NLS(0.037)SSSDTGSVGGTYR 133.92 0.00025219 0.0 318.91 336.78 195.69 450.34 335.64 305.07 306.14 267.83 62.165 317.21 True False 326.3399825091619 297.3496410352255 169.11637284822658 371.6965729287731 305.28142126205483 302.0012727813977 283.0476133252718 260.7262783655509 105.48946464804061 357.9269933870558 0.9117501293238975 0.8307550045930091 0.47248845706740866 1.0384703579113048 0.8529153344182929 0.8437510396284054 0.7907970579329545 0.7284342426881624 0.2947234117488485 1.0 8.483521539779751 -8.007479331655334 22.899894950636423 0.6021008283638851 0.8135855774163766 0.09344236701932684 0.20799812669233111 201.67526341750167 617469.7729371361 0.11575077167534058 0.05166041709743721 9.829256499303303e-09 8.007479331655334 0.21148474905249148 NS(ph)PSNLSSSSDTGSVGGTYR ddPTM_A459_Selumetinib_30min_R2 2 NSPSNLSSSSDTGSVGGTYR 20 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 NS(0.994)PS(0.006)NLSSSSDTGSVGGTYR;NS(0.769)PS(0.23)NLS(0.001)SSSDTGSVGGTYR 258.83 1.6672e-47 10953200.0 20642.4 20119.8 18408.2 23046.0 24187.0 16204.3 23410.0 23493.0 15839.300000000001 17308.3 True False 19495.178046074416 21662.923964646398 17223.836453332737 19907.095043432542 21148.412825476535 18436.295237010352 24498.611386034987 23561.3607405245 19007.60258701934 16808.56440663589 1.1598359963672966 1.288802746062837 1.0247059794430093 1.1843423722476487 1.2581926875996206 1.0968393725362915 1.4575076605806456 1.401747357509167 1.1308284352657318 1.0 14.036908891043796 NS(ph)QDDYDEER ddPTM_A459_Selumetinib_30min_R2 1 NSQDDYDEER 10 0 O76094-2;O76094;R4GNC1;D6RDY6 O76094-2 SRP72 Signal recognition particle subunit SRP72 1 NS(0.6)QDDY(0.4)DEER 99.802 0.015173 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 NS(ph)QDITPVDNSMDSNIHQR ddPTM_A459_Selumetinib_30min_R1 2 NSQDITPVDNSMDSNIHQR 19 0 Q59FP8;Q92859-3;Q92859-2;Q92859-4;Q92859 Q59FP8 NEO1 Neogenin 1 NS(0.985)QDIT(0.015)PVDNSMDSNIHQR;NS(0.999)QDIT(0.001)PVDNSMDSNIHQR 171.32 1.9797e-09 9601100.0 3907.7000000000003 3574.4 4048.5 3164.8999999999996 4469.7 3370.2 4604.7 4740.299999999999 1539.79 3426.6 True False 3998.7418069394234 3155.9075863065227 3498.735936818667 2612.209627530918 4065.4164241896265 3336.2988478967645 4257.363771734759 4614.571845335552 2612.9111681879904 3866.437487910486 1.034218662384333 0.8162313747925224 0.9048991346060703 0.675611499138091 1.0514631199654214 0.8628870525719475 1.1011076178126802 1.19349449196174 0.675792942820878 1.0 11.91678917258101 -6.3162844437282555 24.99904709759956 0.9905862456880837 0.8581423337142848 0.1292908599875422 0.15519228947118197 598.0358977157251 272590.49888537667 0.04704271604830734 0.05334145269379326 4.82742523418475e-07 6.3162844437282555 -0.1324439119737989 NS(ph)SEASSGDFLDLK ddPTM_A459_Selumetinib_30min_R1 1 NSSEASSGDFLDLK 14 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 NS(0.794)S(0.206)EASSGDFLDLK 261.59 6.7678e-36 22843000.0 2760.1 4136.7 2135.3 1801.1 2268.3 2318.8 3418.6 3660.1 2009.2 3064.9 True False 2824.4049597803073 3652.3732409003433 1845.3379883633204 1486.571695834288 2063.1326655008925 2295.4749773019485 3160.73224966935 3563.022258319655 3409.465653838064 3458.3097696541327 0.8167009747258058 1.056115121019254 0.5335953431805716 0.42985498548412593 0.5965725463937337 0.6637563232317156 0.9139529019071813 1.0302785162810892 0.985876304012826 1.0 11.755851385316113 -7.378624258367808 3.4361892022277987 1.002197704782429 0.6770678097849747 0.46544845511658395 0.15922700286874186 0.26254509223883565 5.731310841624521 0.08330940753765392 0.05323571892442182 4.1819202032831206e-08 7.378624258367808 -0.32512989499745437 NS(ph)SEASSGDFLDLK ddPTM_A459_Selumetinib_30min_R2 4 NSSEASSGDFLDLK 14 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 NS(0.769)S(0.229)EAS(0.002)SGDFLDLK;NS(0.954)S(0.046)EASSGDFLDLK;NS(0.949)S(0.05)EASSGDFLDLK;NS(0.992)S(0.008)EASSGDFLDLK 209.19 5.3833000000000015e-06 32378100.0 101083.0 77612.0 86487.0 97600.0 90232.0 82935.0 112312.0 118627.0 94267.0 85888.0 True False 95465.21152730989 83564.59083808676 80922.52057992572 84306.71163060896 78896.24947568514 94358.54344102829 117534.73054200585 118972.18493024299 113123.03404004936 83408.19027617635 1.1445544042043236 1.0018751223518043 0.9701987336253164 1.010772579424844 0.9459053027580201 1.1312863056804585 1.4091509497188668 1.4263849213885256 1.356258104455725 1.0 16.347901435769316 -7.060722591682858 4.233011761464993 1.3311672758145607 1.0123459217732682 0.5357492119676275 0.12249413804315577 0.1507879698766643 5.4054061310419375 0.0458876319994492 0.03601875989779644 8.695156605063133e-08 7.060722591682858 -0.3188213540412925 NS(ph)SEKLPTELSK ddPTM_A459_Selumetinib_30min_R1 1 NSSEKLPTELSK 12 1 P38432 P38432 COIL Coilin 1 NS(0.996)S(0.004)EKLPTELSK 73.80199999999998 0.029217 9619900.0 4718.0 4636.8 5798.6 5308.8 5025.4 4964.3 4468.4 3971.1 2869.1 3773.3 True False 4827.920220370092 4093.92130041016 5011.1819694298465 4381.717738518162 4570.853457306433 4914.363649223758 4131.344990470519 3865.773528049284 4868.653149226948 4257.639810054468 1.13394284997263 0.9615471207175192 1.176985887250462 1.0291424202138195 1.073565087988962 1.1542459833305834 0.9703368943315256 0.9079616173543409 1.143509870827862 1.0 12.055838189776827 -7.281169156317849 24.84061215178604 0.9977822275458061 1.0831603947453834 0.199841794046404 0.08018572215317303 1219.7758926038148 1535742.450871911 0.03210706626856465 0.021684140366462656 5.233965355948862e-08 7.281169156317849 0.08537816719957725 NS(ph)SEKLPTELSK ddPTM_A459_Selumetinib_30min_R2 1 NSSEKLPTELSK 12 1 P38432 P38432 COIL Coilin 1 NS(0.971)S(0.029)EKLPTELSK 127.05 0.012571 11967000.0 23862.0 19234.0 21741.0 21095.0 20883.0 18290.0 21267.0 13749.0 11234.0 21919.0 True False 22535.845567154385 20709.18595294233 20342.207729811 18221.82460909525 18259.490843611293 20809.281479910842 22255.957639761044 13789.007313730513 13481.113904186122 21286.141517598622 1.058709750121813 0.9728952490436426 0.9556550074137574 0.8560416923861046 0.8578112115112547 0.9775976290821176 1.0455609167758568 0.6477927106859763 0.6333282099548393 1.0 14.377626839536088 -7.76289809160097 24.999823180982208 0.7304203298518783 0.9535698171671921 0.3878788795548923 0.11317281299515267 35.8820650338887 614913.348261649 0.05734799576454378 0.029881280808525413 1.726242912133349e-08 7.76289809160097 0.2231494873153138 NS(ph)SIVGR ddPTM_A459_Selumetinib_30min_R2 1 NSSIVGR 7 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7;A0A0U1RQT6 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 NS(0.5)S(0.5)IVGR 88.177 0.03262 6865200.0 24504.0 27797.0 30234.0 29310.0 33684.0 16739.0 20445.0 28816.0 19676.0 27111.0 True False 23142.165777284026 29928.94051855764 28288.777356290244 25317.927437429822 29452.314781219313 19044.645308487023 21395.733010998938 28899.84978925441 23611.749793374227 26328.23498716255 0.8789866008324513 1.1367621313449523 1.0744653931447985 0.961626461089194 1.1186589148714314 0.7233544260666562 0.8126535265820644 1.0976751690094593 0.896822358387759 1.0 14.684323187655083 -6.72534316550038 24.999988348213098 0.9063646506042827 1.038019544646083 0.23054979514803742 0.11680819451917586 270.68455454813187 187473.55099701893 0.039201149361685304 0.03919993250567144 1.8821612785850948e-07 6.72534316550038 0.1316548940418002 NS(ph)SPAPPQPAPGK ddPTM_A459_Selumetinib_30min_R2 2 NSSPAPPQPAPGK 13 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 NS(0.5)S(0.5)PAPPQPAPGK;NS(0.774)S(0.226)PAPPQPAPGK 196.37 0.00019025 501610000.0 173382.0 139935.0 160489.0 163898.0 163158.0 130845.0 160414.0 152035.0 127404.0 130865.0 True False 163746.12254313816 150667.56453805638 150163.31246721154 141574.80966017977 142660.63338897345 148867.71105735024 167873.56885431096 152477.39667925067 152888.3599651884 127086.5874218962 1.2884610867670978 1.1855504785715674 1.1815826950227744 1.11400276403824 1.122546731980262 1.1713880597261304 1.3209385212068998 1.1997914160135816 1.2030251426740783 1.0 16.955452252372268 -11.984305500698268 1.5347262291413597 4.549737559094574e-05 1.1958140975545801 0.48728061716463855 0.061051816717904966 409827.42128688726 33067.348201819914 1413117.8484844004 0.018046277837530482 1.0367988320644323e-12 11.984305500698268 1.1957686001789891 NS(ph)SPEKHILENK ddPTM_A459_Selumetinib_30min_R2 1 NSSPEKHILENK 12 1 E7EVA0;B5MEG9 E7EVA0 MAP4 Microtubule-associated protein 1 NS(0.643)S(0.357)PEKHILENK 62.528 0.037565 5416600.0 65766.0 75111.0 72456.0 70242.0 58409.0 39022.0 39104.0 36117.0 23947.0 64705.0 True False 62110.989002157294 80871.77218006927 67794.25984412814 60674.91842579142 51071.139236914816 44396.92629355282 40922.41348310603 36222.0944905088 28737.069135084992 62836.798526220104 0.9884492917989774 1.2870129299525603 1.0788942376788886 0.9655953175347309 0.8127584541978886 0.7065434161962783 0.6512491795079313 0.5764471669477925 0.45732866423953455 1.0 15.939322058144572 -6.265500817151649 1.2582689174339974 0.6386367670615583 1.1479318590709473 0.6324043118611127 0.14712348225748703 0.25870565622474684 0.8362223528573242 0.056927849498817476 0.08161011618833146 5.42624230347353e-07 6.265500817151649 0.509295092009389 NS(ph)SPPPSPNK ddPTM_A459_Selumetinib_30min_R2 1 NSSPPPSPNK 10 0 P20020-6;P20020;P20020-4;P20020-1;A0A0U1RQU3;E7ERY9 P20020-6 ATP2B1 Plasma membrane calcium-transporting ATPase 1;Calcium-transporting ATPase 1 NS(0.501)S(0.499)PPPSPNK 113.69 0.0074762 6196300.0 45678.0 11317.0 23988.0 29260.0 13832.0 12850.0 48509.0 29192.0 17870.0 14420.0 True False 43139.39962352188 12184.977510109607 22444.638196159627 25274.737523684624 12094.300500351066 14619.970859314062 50764.76461875993 29276.94388700426 21444.499329518054 14003.65713234052 3.08058096651726 0.8701282382849268 1.602769761073714 1.804866920464247 0.8636530005022816 1.0440109123744687 3.6251076514521383 2.0906641465386278 1.5313499271553428 1.0 13.773516023697317 NS(ph)T(ph)Y(ph)SKPNS(ph)FLK ddPTM_A459_Selumetinib_30min_R2 1 NSTYSKPNSFLK 12 1 Q9Y251-2 Q9Y251-2 4 NS(0.993)T(0.99)Y(0.989)S(0.028)KPNS(1)FLK 68.069 0.025952 3662200.0 33685.0 27459.0 31933.0 31432.0 33410.0 27174.0 27162.0 27701.0 25999.0 34368.0 True False 31812.92255173898 29565.017005398928 29878.465546021576 27150.907376775634 29212.73711081039 30916.971838988356 28425.08682048195 27781.605323852586 31199.52647275545 33375.70654121215 0.9531760028048109 0.8858244534506616 0.8952159712073151 0.8134931119210864 0.875269474063078 0.9263316059185814 0.8516699649603761 0.8323900286439779 0.9347974831403324 1.0 15.026510757554545 -8.532955476251923 6.0994181607585505 0.9999775659981245 0.8784230604458674 0.48798414556495806 0.039098498570555966 0.11145840093058106 25.786058606200207 0.03854726191904412 0.00998894822703993 2.931193735003891e-09 8.532955476251923 -0.12155450555225711 NS(ph)TELAPPLPVR ddPTM_A459_Selumetinib_30min_R1 4 NSTELAPPLPVR 12 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 NS(0.996)T(0.004)ELAPPLPVR;NS(1)TELAPPLPVR;NS(0.968)T(0.032)ELAPPLPVR;NS(0.93)T(0.07)ELAPPLPVR 158.31 0.00045283 148057000.0 8537.7 12776.199999999999 6244.2 6748.599999999999 7394.0 8014.499999999999 9434.099999999999 8836.0 4535.27 8460.7 True False 8736.61179852771 11280.356564505757 5396.27193693544 5570.083696911481 6725.21400551673 7933.881406583768 8722.478241562518 8601.640576627 7696.021946984945 9546.713259196938 0.9151434175642799 1.1815958286626753 0.5652491900012685 0.5834556402482787 0.7044533362346372 0.8310589405144823 0.9136629544371845 0.90100543957791 0.8061436159267581 1.0 13.220788412489995 -9.831181338017846 9.59992792626188 0.9999996067749188 0.820170272081965 0.0891117495108682 0.1701904320780354 0.0 0.0 0.17932840976457104 0.043493527949021886 1.4750904862189978e-10 9.831181338017846 -0.1798293346929538 NS(ph)TELAPPLPVR ddPTM_A459_Selumetinib_30min_R2 5 NSTELAPPLPVR 12 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 NS(0.774)T(0.226)ELAPPLPVR;NS(0.967)T(0.033)ELAPPLPVR;NS(0.888)T(0.112)ELAPPLPVR;NS(0.765)T(0.235)ELAPPLPVR;NS(0.77)T(0.23)ELAPPLPVR 183.28 0.0001043 137011500.0 104388.0 86177.0 105336.0 118823.0 125580.0 101886.0 115800.0 118074.0 94869.0 107111.0 True False 98586.53285827319 92786.49879727121 98558.79644116508 102639.10241889204 109803.51770055578 115919.87167097842 121184.92945334685 118417.57579179695 113845.45086133473 104018.42712220004 0.9477795000923682 0.8920198215289907 0.9475128510199349 0.986739611995021 1.0556160166848079 1.1144166940228453 1.1650332811798791 1.1384288252376755 1.0944738736300057 1.0 16.666479602446472 -6.211848402113383 1.5584519343768555 1.115226235516008 0.9220125116128856 0.7540274359347072 0.04355608049115917 0.17061433154345518 0.8252112448548238 0.015421687660789043 0.021887218407331335 6.139762866445532e-07 6.211848402113383 -0.19321372390312253 NS(ph)TELAPPLPVRR ddPTM_A459_Selumetinib_30min_R1 2 NSTELAPPLPVRR 13 1 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 NS(0.836)T(0.164)ELAPPLPVRR;NS(0.818)T(0.182)ELAPPLPVRR 127.3 0.00099658 15903300.0 2864.8 3071.3 3722.0 4267.299999999999 3191.8 2998.5 3035.6 2837.9 1706.72 2218.6000000000004 True False 2931.5442660695735 2711.7107681913676 3216.5728434825437 3522.0961621418305 2903.1022535580573 2968.3378124201686 2806.6222480244187 2762.629673201647 2896.1791861031747 2503.3789209940464 1.1710349725664024 1.0832202610041137 1.2848925172723356 1.40693689341415 1.159673523337525 1.1857325263574143 1.1211336104523721 1.1035603320110472 1.1569080341034246 1.0 11.28966096404793 -7.15066191767349 1.590047523766067 1.0958062086499811 1.227680095526803 0.3259357575948165 0.08728522602931019 0.5549018870914791 2.7707617223937104 0.05042304932735118 0.03337165761890859 7.068676106465028e-08 7.15066191767349 0.1318738868768219 NS(ph)TGSGHSAQELPTIR ddPTM_A459_Selumetinib_30min_R1 3 NSTGSGHSAQELPTIR 16 0 O94763-2;O94763-3;O94763;I3L280;O94763-4 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 NS(0.958)T(0.041)GS(0.001)GHSAQELPTIR;NS(0.943)T(0.055)GS(0.002)GHSAQELPTIR;NS(0.869)T(0.129)GS(0.002)GHSAQELPTIR 149.24 0.00026499 11041900.0 7219.469999999999 6292.4400000000005 8180.45 6097.34 8707.95 6013.13 6770.5599999999995 7820.82 3114.5299999999997 6164.08 True False 7387.669604356776 5555.718199524011 7069.589821995375 5032.554030247203 7920.3174600134425 5952.64337168521 6259.851208190868 7613.386447996371 5285.1299337289765 6955.299711223741 1.0621640922871118 0.7987748091658465 1.0164320899913493 0.7235567465376351 1.1387456743571318 0.8558428276037411 0.9000117130954645 1.09461658937726 0.759870911845881 1.0 12.763896968024849 -6.257448127098143 24.999274891851442 0.9548867093600427 0.9012850266782949 0.04088125828152367 0.13691329450436415 1454.060787832718 9107536.243486116 0.038394378337304316 0.04767265286770125 5.527794289552394e-07 6.257448127098143 -0.05360168268174781 NS(ph)TGSGHSAQELPTIR ddPTM_A459_Selumetinib_30min_R2 2 NSTGSGHSAQELPTIR 16 0 O94763-2;O94763-3;O94763;I3L280;O94763-4 O94763-2 URI1 Unconventional prefoldin RPB5 interactor 1 1 NS(0.489)T(0.489)GS(0.021)GHSAQELPTIR;NS(0.719)T(0.179)GS(0.102)GHSAQELPTIR 116.0 0.0012937 13023600.0 27918.5 26437.0 37399.0 37540.0 36343.0 31557.0 28612.0 29242.0 33780.0 51648.0 True False 26366.901536610523 28464.632891646866 34992.7890569524 32426.987239887956 31777.267429457675 35903.69030407581 29942.514693602425 29327.0893787263 40536.94389206042 50156.78804238031 0.5256895938857097 0.5675130725595006 0.6976680609488992 0.6465124364121674 0.6335586601479996 0.7158291370998229 0.5969783126523632 0.5847082822358199 0.8082045416825429 1.0 15.614157342846914 -14.522878745280314 0.18658358331034702 2.5516159211447924 0.5710649839254606 0.7539433649174966 0.0658248716257943 69.70777938152526 0.6764663990390514 39.97650912322972 0.19375973303109925 3.0000000000001608e-15 14.522878745280314 -1.980550937219332 NS(ph)WDSPAFSNDVIR ddPTM_A459_Selumetinib_30min_R1 4 NSWDSPAFSNDVIR 14 0 A0A0C4DGT3;A0A3B3IU98;A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2;A0A2R8Y695 A0A0C4DGT3;A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 NS(0.572)WDS(0.427)PAFS(0.001)NDVIR;NS(0.989)WDS(0.011)PAFSNDVIR;NS(1)WDSPAFSNDVIR;NS(0.996)WDS(0.003)PAFSNDVIR 209.33 5.2705e-06 91667800.0 9020.269999999999 10380.03 9047.13 9536.01 8477.24 9304.880000000001 9185.03 8747.02 5036.750000000001 7694.820000000001 True False 9230.424740609944 9164.731262054967 7818.579438327847 7870.724866577493 7710.47513877828 9211.281355355071 8492.195792189928 8515.020615274772 8546.996880334895 8682.525100893992 1.0631037207896512 1.0555375487611691 0.9004960362882004 0.906501826958967 0.8880452459601152 1.060898903062962 0.9780790373200917 0.9807078604815122 0.9843906906131324 1.0 13.083898961059312 -9.765240058828985 15.505634422583567 1.0 0.9771632079276594 0.007771304923289923 0.06278416409882326 0.0 0.0 0.06536194025193058 0.01585259903258944 1.7169590655891727e-10 9.765240058828985 -0.022836792072340573 NS(ph)WDSPAFSNDVIR ddPTM_A459_Selumetinib_30min_R2 2 NSWDSPAFSNDVIR 14 0 A0A0C4DGT3;A0A3B3IU98;A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2;A0A2R8Y695 A0A0C4DGT3;A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 NS(0.515)WDS(0.305)PAFS(0.18)NDVIR;NS(0.628)WDS(0.342)PAFS(0.03)NDVIR 95.751 0.012279 33140000.0 20248.0 17843.8 23353.0 25629.0 24470.0 21103.0 19224.7 20667.4 19442.6 20947.0 True False 19122.697219166137 19212.362083139866 21850.493404823897 22138.285987508993 21395.859835424428 24009.746696039274 20118.68664302036 20727.538712327747 23331.663271633355 20342.2056831579 0.9400503326440436 0.9444581567202678 1.0741457315474283 1.088293291903844 1.051796455540654 1.1802921998727933 0.989012054856834 1.0189425392296019 1.1469583797862464 1.0 14.312188497074759 -5.259620615072243 21.426627605645404 1.0705949643594503 0.942254119597387 0.43736086087859416 0.057324676627833526 18.70329037322909 220296.27669944498 0.014521866763289294 0.034489071492280456 5.500211438673914e-06 5.259620615072243 -0.1283408447620633 NSAECVS(ph)EDDTTESQNYFGSLRK ddPTM_A459_Selumetinib_30min_R1 1 NSAECVSEDDTTESQNYFGSLRK 23 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 NS(0.003)AECVS(0.978)EDDT(0.016)T(0.004)ESQNYFGSLRK 87.439 0.0020096 0.0 551.91 618.67 1036.8 1154.9 929.28 817.04 812.44 676.48 449.81 657.97 True False 564.768429170084 546.2358287881199 896.0082547347403 953.21839515797 845.2267880777091 808.8213194129644 751.1569967008035 658.5375528832767 763.294717177434 742.4268586705373 0.7607058157640121 0.7357436256633597 1.2068640085829074 1.283922293523832 1.1384647230991285 1.0894289585122494 1.0117589199909864 0.8870066393644742 1.0281076287356639 1.0 9.536105093356959 -5.249356994922545 24.598134021757776 1.083830036534389 0.7482246424654353 0.6109575352627932 0.10609820961107576 453.77640971221115 923823.3342421212 0.031309304597571815 0.0814354397701157 5.631745297409818e-06 5.249356994922545 -0.3356053940689536 NSAEEEVLS(ph)SEK ddPTM_A459_Selumetinib_30min_R1 2 NSAEEEVLSSEK 12 0 A0A0U1RRH6;O94880 A0A0U1RRH6 PHF14 PHD finger protein 14 1 NSAEEEVLS(0.979)S(0.021)EK;NSAEEEVLS(0.922)S(0.078)EK 97.223 0.017976 2283600.0 1379.63 1617.05 1546.5 1642.8200000000002 1801.65 1346.23 1722.3899999999999 1206.55 950.7 1847.32 True False 1411.772694707331 1427.7250342538493 1336.4937943164316 1355.9323265507098 1638.691075607143 1332.6881484790404 1592.468735595855 1174.548374573258 1613.2684636192748 2084.4415164205907 0.6772906236926385 0.6849436758031682 0.6411759619005588 0.6505014968609534 0.7861535393044311 0.6393502230600053 0.7639786115613582 0.5634834872173319 0.7739571731374764 1.0 11.025445179401997 -8.539559859615498 22.54699022898954 1.00000000245921 0.6788805229550462 0.7294713529735577 0.05991210047896792 397.53970158611753 537333.9213501394 0.053982030659506505 0.0139381003917395 2.886955837277048e-09 8.539559859615498 -0.32111947950416375 NSAIS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 NSAISPQK 8 0 Q9H582;Q9H582-2 Q9H582 ZNF644 Zinc finger protein 644 1 NS(0.001)AIS(0.999)PQK 87.713 0.032085 3783600.0 2753.9 3344.9 3491.3 3990.4 3057.7 3072.9 2617.1 2273.7 1791.1 2289.6 True False 2818.0605118434096 2953.277552998177 3017.2006363381533 3293.5515490850803 2781.13157488078 3041.9894159699647 2419.6900399607016 2213.39408998153 3039.3658832318124 2583.4924625926124 1.0907949423685956 1.1431337988245858 1.1678766940586705 1.2748446518709415 1.0765007504956414 1.1774717596494308 0.9365965161487136 0.8567449381138595 1.1764562611426075 1.0 11.335106959330174 -7.256775996862792 24.89587369944961 0.9805115045179933 1.1570101725086095 0.4356054694117757 0.0902780951931291 333.055747298216 1778051.4694660844 0.03476912463794456 0.02600624976005152 5.536355932306484e-08 7.256775996862792 0.1764986679906162 NSAIS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 1 NSAISPQK 8 0 Q9H582;Q9H582-2 Q9H582 ZNF644 Zinc finger protein 644 1 NS(0.001)AIS(0.999)PQK 91.701 0.026497000000000003 4733000.0 104190.0 99511.0 92126.0 98608.0 110190.0 64975.0 85370.0 88034.0 55594.0 103450.0 True False 98399.5369056162 107143.17372170328 86198.71345920484 85177.42029171184 96346.94708890135 73924.7164656755 89339.87415744583 88290.16436518682 66714.35342614597 100463.12970462049 0.9794592025445393 1.0664924936812472 0.8580134195763602 0.8478475689752911 0.9590279276803196 0.7358392743987506 0.8892802207150124 0.8788315138576277 0.6640680379189665 1.0 16.616306599203867 -5.273039172780169 22.883332440550102 0.8503410580585357 1.0229758278721686 0.3403617844029536 0.09391452411273646 215.77714000443785 425674.10416927555 0.023369650897585324 0.04947127485522481 5.332867915643814e-06 5.273039172780169 0.1726347698136329 NSAPASVS(ph)PDGTR ddPTM_A459_Selumetinib_30min_R1 1 NSAPASVSPDGTR 13 0 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;A0A590UJM5 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 NSAPAS(0.001)VS(0.771)PDGT(0.228)R 185.86 0.00012879 6572100.0 2646.6 2813.7 3528.1 3766.4 2848.8 2386.9 2439.7 2345.6 1649.3 2027.4 True False 2708.260630612864 2484.270695946357 3049.0033984660854 3108.668944084314 2591.12654299649 2362.889953131801 2255.67146478626 2283.3870684174153 2798.7416398940477 2287.636538548334 1.1838684095907321 1.0859551568112307 1.3328181059745146 1.358899847812792 1.1326653073310071 1.0328957040663551 0.9860270312947711 0.9981424190166086 1.223420588337886 1.0 11.159642138488465 -6.520437999724717 5.311912905747948 1.0467720226202435 1.2377424005797528 0.4781442369894978 0.09458424402377884 0.16392778831482388 14.863975186506588 0.032780919068410554 0.034640879257586736 3.01690753888489e-07 6.520437999724717 0.19097037795950933 NSAPASVS(ph)PDGTR ddPTM_A459_Selumetinib_30min_R2 2 NSAPASVSPDGTR 13 0 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;A0A590UJM5 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 NSAPAS(0.003)VS(0.764)PDGT(0.233)R;NSAPAS(0.01)VS(0.975)PDGT(0.015)R 154.47 0.00038389 12305300.0 29835.2 25477.0 32137.0 37716.0 33815.0 26085.0 29660.0 30277.0 20883.8 32768.0 True False 28177.07902376853 27431.003978533387 30069.34040811998 32579.015736271012 29566.857390064437 29677.971973946118 31039.248770175014 30365.101057372838 25061.143542125865 31821.902698511403 0.8854617931154263 0.8620164620079924 0.9449259113449113 1.023792198880522 0.9291354344895142 0.9326271987920579 0.9754051812755684 0.9542201591482237 0.7875438429801433 1.0 14.957732479569133 -5.267560820343018 23.579411877166965 0.9449332175410249 0.8737391259216245 0.1784879507769137 0.05976047460095007 338.9431015913833 1305600.6245015503 0.015534364879645131 0.033780267784744085 5.4005647779092975e-06 5.267560820343018 -0.07119409161940038 NSAPASVSPDGT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 NSAPASVSPDGTR 13 0 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;A0A590UJM5 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 NSAPASVS(0.015)PDGT(0.985)R 106.6 0.016143 3337900.0 15831.0 13070.0 16105.0 16458.0 15704.0 12505.0 15261.0 15723.0 9670.7 14376.0 True False 14951.176396514173 14072.426973326206 15068.821833798189 14216.392008366434 13731.12312445873 14227.450240912249 15970.666739097811 15768.75132691723 11605.110221934545 13960.927526666257 1.0709300200832987 1.0079865357403353 1.0793567837821507 1.018298532186506 0.9835394602709179 1.0190906165608922 1.143954562373655 1.1294916685727303 0.831256390362893 1.0 13.769107173079075 -8.259284079918249 24.9999088588349 0.9156281973159693 1.0536723671533847 0.45142460601926415 0.062086390104817354 171.51024972374057 1989457.2615189382 0.04803944954109836 0.016167720848618415 5.50447520886279e-09 8.259284079918249 0.1380441698374154 NSASAT(ph)TPLSGNSSR ddPTM_A459_Selumetinib_30min_R2 1 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NS(0.013)AS(0.013)AT(0.956)T(0.019)PLSGNSSR 149.31 0.00067303 4747600.0 16576.0 16217.0 21323.0 21757.0 19511.0 13840.0 16521.0 17477.0 13540.0 21233.0 True False 15654.77227898548 17460.79175412631 19951.101394727022 18793.659067081568 17059.853749446916 15746.33437298885 17289.259235740454 17527.8551765269 16248.378339209534 20619.948120040663 0.7592052214607904 0.8467912553648014 0.9675631227867356 0.9114309579089526 0.8273470743055038 0.7636456833606134 0.8384724896051949 0.8500436118697827 0.7879931726606832 1.0 14.33175308242743 -10.742579373657943 5.282533705314433 1.000011854387265 0.8430227047994371 0.3856465233296824 0.06072418070115345 9.216661443649997e-06 1.361425000322698e-06 0.06391990715106699 0.015501684212367575 1.8089252725336268e-11 10.742579373657943 -0.15698914958782784 NSASATT(ph)PLSGNSSR ddPTM_A459_Selumetinib_30min_R1 2 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NS(0.008)AS(0.026)AT(0.221)T(0.746)PLSGNSSR;NSAS(0.001)AT(0.227)T(0.772)PLSGNSSR 179.55 4.6762e-05 21781200.0 6408.8 6876.7 8837.6 9221.7 7654.4 6187.1 6682.3 6707.4 4112.299999999999 5822.299999999999 True False 6558.112570646002 6071.572767108905 7637.502461461944 7611.303207748066 6962.060871494083 6124.86339143733 6178.248731049404 6529.497963294243 6978.272749491473 6569.648919004619 0.9982439931721093 0.9241852710797249 1.1625434715953007 1.158555548642814 1.0597310384964862 0.9322969106795621 0.940422967379128 0.9938884168384969 1.062198731701597 1.0 12.68160055987568 -6.681654856929932 9.331776262397371 0.9826285529817611 1.0644777586057637 0.20594997233179058 0.07322863348621136 0.5483169565385788 59.01849574443987 0.026842729788988686 0.02681818517569012 2.0813501232571346e-07 6.681654856929932 0.08184920562400255 NSASATT(ph)PLSGNSSR ddPTM_A459_Selumetinib_30min_R2 2 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NS(0.004)AS(0.013)AT(0.032)T(0.952)PLSGNSSR;NSAS(0.021)AT(0.226)T(0.753)PLSGNSSR 196.45 4.646e-05 11918200.0 56424.0 64175.0 59785.0 69665.0 70729.0 43607.0 46881.0 55205.0 43601.0 62264.0 True False 53288.17996316824 69097.01614485156 55938.49818898629 60176.506821171846 61843.390694717345 49613.468425066785 49061.05939293915 55365.63741032027 52322.41831372784 60466.27653869978 0.881287603827608 1.142736416068681 0.9251189487942819 0.9952077466297685 1.0227749124776384 0.8205146945556181 0.8113788743307018 0.9156448946361864 0.8653156984164605 1.0 15.883843121354436 -6.75365326779469 24.992635316105236 0.8728491382366755 0.9980244578382962 0.3165612475452727 0.08067084617967735 186.74628745076606 599436.1033986906 0.025564408626898023 0.02511207362564526 1.7633833352662248e-07 6.75365326779469 0.12517531960162065 NSASATTPLS(ph)GNSSR ddPTM_A459_Selumetinib_30min_R1 4 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NSAS(0.001)AT(0.02)T(0.091)PLS(0.846)GNS(0.037)S(0.005)R;NSASAT(0.029)T(0.321)PLS(0.65)GNSSR;NSASAT(0.006)T(0.196)PLS(0.798)GNSSR;NSASATTPLS(0.999)GNSSR 216.77 3.4502e-09 163980400.0 11772.8 14189.4 15766.400000000001 16737.399999999998 13715.3 12280.0 12927.300000000001 11837.5 7070.41 10337.5 True False 12047.083334118905 12528.098451526896 13625.409478636 13814.527289909951 12474.753536632883 12156.474349347902 11952.183353171058 11523.531046380953 11997.969367685246 11664.418820777048 1.0328061362697507 1.074043948868797 1.1681173051130478 1.1843305270643283 1.0694706464425334 1.042184315921029 1.024670284633593 0.9879215778719176 1.0285955564553346 1.0 13.509826806436868 -6.735911971455522 2.407147917913648 1.0121133405451026 1.1159340165056386 0.54307523664981 0.04248692030735077 0.24529111263114697 2.9145415742373824 0.017791769400393048 0.016710779550087863 1.83691063493751e-07 6.735911971455522 0.10382067596053601 NSASATTPLS(ph)GNSSR ddPTM_A459_Selumetinib_30min_R2 4 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NSASAT(0.002)T(0.019)PLS(0.975)GNS(0.004)SR;NSASATTPLS(0.999)GNSSR;NSASAT(0.004)T(0.149)PLS(0.847)GNSSR;NSASAT(0.007)T(0.106)PLS(0.872)GNS(0.012)S(0.003)R 199.05 1.9867e-05 172043000.0 280318.0 283695.0 280268.0 301530.0 309300.0 209892.0 244801.0 245148.0 200520.0 267141.0 True False 264739.0477618633 305453.4942768003 262235.86201272625 260461.09383173726 270442.9688229167 238802.7177901281 256184.7315639791 245861.34009356372 240629.60299691992 259427.94521432664 1.020472360998538 1.1774116856395314 1.0108234939612224 1.003982410671129 1.042458893930991 0.9204972794771242 0.9874985956209608 0.9477056910366581 0.9275392548714193 1.0 17.98497436748299 -5.917113220407604 0.9423044080752275 0.957005116960874 1.0988138920844153 0.4659853920792967 0.050704968227767606 0.521991162243835 0.9159200012838108 0.020959082069231225 0.05213247722776623 1.2102825722088868e-06 5.917113220407604 0.1418087751235413 NSASATTPLSGNS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NSASATTPLS(0.002)GNS(0.499)S(0.499)R 97.957 0.0091917 56690000.0 3134.2 3438.6 3896.6 3658.6 2937.8 2832.5 3143.3 3033.2 2059.6 2836.9 True False 3207.2207619084243 3036.007113438231 3367.4631224916957 3019.694190427696 2672.076508710716 2804.007621704229 2906.198350314652 2952.7496827778423 3494.990772767706 3201.0437487460613 1.001929687204301 0.9484428679325362 1.0519890969346561 0.9433467417027945 0.8347516367926691 0.8759666664357955 0.9078908563661748 0.922433404396462 1.0918284931709514 1.0 11.644326679030018 -10.921257164888512 7.074928950672682 1.0000028998436798 0.9476635183344161 0.030118130897017203 0.07398606639416938 3.5804947068283427e-06 3.044376770251093e-07 0.0757923909835896 0.018381336260166522 1.198789237039013e-11 10.921257164888512 -0.05233938150926376 NSASATTPLSGNS(ph)SR ddPTM_A459_Selumetinib_30min_R2 2 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NSASAT(0.002)T(0.003)PLS(0.204)GNS(0.442)S(0.349)R;NSASAT(0.001)T(0.008)PLS(0.024)GNS(0.592)S(0.376)R 88.54799999999999 0.017513 66579000.0 38517.0 35220.0 32421.0 42562.0 39604.0 27018.0 33512.0 28300.0 23513.0 36013.0 True False 36376.3793357676 37921.260749850684 30335.068157315804 36764.982176454716 34628.59145574779 30739.484255015377 35070.37440276823 28382.348314682804 28216.25700811183 34973.21111698887 1.0401212291912514 1.084294508245191 0.8673801229129915 1.051232672157904 0.9901461818850922 0.8789437192995733 1.0027782203199571 0.8115453916925451 0.8067962908446024 1.0 15.093962644840774 -6.880095709754061 0.9626511536685504 0.8745093694854661 1.0154605036268802 0.2762341007303617 0.08280836978009243 0.6915168661297882 1.3581767623941732 0.051654214707257826 0.04192256988108109 1.3179662533399284e-07 6.880095709754061 0.14095113414141414 NSASATTPLSGNSS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 NSASATTPLSGNSSR 15 0 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 NSASATTPLS(0.001)GNS(0.216)S(0.782)R;NSASATT(0.001)PLS(0.017)GNS(0.246)S(0.736)R;NSASATTPLSGNS(0.013)S(0.987)R 175.16 2.0674e-05 112247000.0 13728.599999999999 15438.099999999999 17188.1 17322.5 14243.3 14331.999999999998 13779.3 12785.4 8754.5 12579.2 True False 14048.449668794574 13630.600075022026 14854.050427475097 14297.45055859722 12954.996029858854 14187.833092414825 12739.916307221916 12446.289659167818 14855.747096618219 14193.862851784153 0.9897552072675339 0.9603164562991867 1.0465121850608805 1.0072980631061998 0.9127181349529825 0.9995751854563981 0.8975651265800784 0.8768782528854245 1.0466317204657833 1.0 13.7929796510276 -6.23796096191104 23.97447104300767 0.9487061890688239 1.0013196089909429 0.1438560997827314 0.05269822276315662 816.870844036789 834128.2959104934 0.015387824954931947 0.019849802150136105 5.781480139403817e-07 6.23796096191104 0.05261341992211899 NSATCHSEDS(ph)DLEID ddPTM_A459_Selumetinib_30min_R1 1 NSATCHSEDSDLEID 15 0 Q13371-2;Q13371 Q13371-2 PDCL Phosducin-like protein 1 NSATCHS(0.006)EDS(0.994)DLEID 78.964 0.031981 10458000.0 2406.2 2575.8 3000.5 3168.6 2771.4 2610.6 2910.5 2539.9 895.3 1716.8 True False 2462.2597783498327 2274.2241385430666 2593.048580566732 2615.26349198852 2520.7273593304117 2584.3397342351486 2690.958641743007 2472.533601242068 1519.258709875184 1937.1680030481305 1.2710615571160948 1.1739942715162437 1.3385770240302208 1.3500447497963044 1.3012435448882347 1.3340813652552048 1.38911990984199 1.2763650841597325 0.7842679145456837 1.0 10.919733363360029 -8.227011293150333 9.052189209506171 0.8923977928947094 1.3066393610749782 0.8354867862771602 0.07315662890246606 0.12899966142553324 33.15158718708587 0.05060528248147203 0.018726565594733763 5.929099066825885e-09 8.227011293150333 0.4142415681802688 NSATCHSEDS(ph)DLEID ddPTM_A459_Selumetinib_30min_R2 2 NSATCHSEDSDLEID 15 0 Q13371-2;Q13371 Q13371-2 PDCL Phosducin-like protein 1 NSATCHS(0.007)EDS(0.993)DLEID;NSATCHS(0.002)EDS(0.998)DLEID 145.52 0.00036124 42766000.0 93607.0 82777.0 117548.0 121049.0 121816.0 89121.0 88030.0 89749.0 72467.0 109216.0 True False 88404.69767851068 89125.72972999392 109985.08965658542 104561.91737882761 106512.38503114268 101396.60879011119 92123.56942813586 90010.1547312531 86962.42489715626 106062.6503027534 0.8335139412994254 0.8403121124692488 1.0369822868147789 0.9858505051529263 1.0042402742822805 0.956006742247878 0.8685769134108118 0.8486508160443019 0.8199156314586145 1.0 16.694557178668 -7.264238808634605 23.543374856757335 0.8716733997642557 0.9471864911017072 0.11603096740083485 0.0754459508395267 208.2325834204846 1751220.8220657175 0.03238089833278125 0.02295105038820679 5.4420332555129797e-08 7.264238808634605 0.07551309133745143 NSATFKS(ph)FEDR ddPTM_A459_Selumetinib_30min_R1 2 NSATFKSFEDR 11 1 O43399;O43399-5;O43399-7;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 1 NSAT(0.013)FKS(0.987)FEDR;NSAT(0.001)FKS(0.999)FEDR 143.05 0.0041338 240540000.0 6391.7 4719.299999999999 10577.2 14524.5 6585.6 6964.3 5937.1 5959.700000000001 1928.6 3302.3999999999996 True False 6540.614173916815 4166.762162056953 9140.874336400751 11988.068733632286 5989.933642782112 6894.245465078467 5489.259767013371 5801.62939616613 3272.693340629152 3726.295208100038 1.7552592611822992 1.1182050614238639 2.453073045992375 3.2171548586846286 1.6074769464752785 1.8501608380603054 1.4731145710305202 1.5569430418596015 0.8782700129380869 1.0 11.863526258026761 -7.667839727770353 1.0559195523829619 0.9690726965904879 2.052367597490263 0.3754447278698526 0.5288374978559037 0.6441232848474319 1.3065612300544243 0.4913307338527462 0.20760589452198258 2.1486232567237936e-08 7.667839727770353 1.083294900899775 NSATFKS(ph)FEDR ddPTM_A459_Selumetinib_30min_R2 2 NSATFKSFEDR 11 1 O43399;O43399-5;O43399-7;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 1 NSAT(0.029)FKS(0.971)FEDR;NSATFKS(1)FEDR 143.05 0.0041338 121212000.0 228908.0 401760.0 341120.0 286546.0 220097.0 101654.0 61262.0 60497.0 61002.0 333070.0 True False 216186.2097513277 432573.700137991 319172.71058337425 247517.94048057913 192446.44716785493 115655.91577686487 64110.80438835003 60673.03625418252 73204.10453829111 323453.4036802129 0.6683689436920054 1.3373601737258622 0.9867656575935406 0.765235232229281 0.5949742527925909 0.35756592591373637 0.19820723374342397 0.1875789080091667 0.22632040258468095 1.0 18.303198368659622 -6.260749875073809 1.554869797001714 0.3303687355058399 1.0306272082879468 0.4745600657907145 0.2716904932959414 0.28749566304085894 1.3843007703217172 0.09583877099911935 0.13059333315749797 5.485928271751974e-07 6.260749875073809 0.700258472782107 NSCNVLHPQS(ph)PNNSNR ddPTM_A459_Selumetinib_30min_R2 2 NSCNVLHPQSPNNSNR 16 0 Q7Z333-3;Q7Z333;Q7Z333-4 Q7Z333-3 SETX Probable helicase senataxin 1 NS(0.007)CNVLHPQS(0.959)PNNS(0.034)NR;NS(0.002)CNVLHPQS(0.837)PNNS(0.161)NR 89.831 0.01543 10150000.0 30807.0 30612.0 35738.0 38654.0 39579.0 24861.0 25686.0 30516.0 23199.0 34369.0 True False 29094.870270192183 32959.841966906024 33438.65598859231 33389.25851813076 34606.732179250655 28285.377084311815 26880.4498958434 30604.796507804258 27839.448234218773 33376.677668613826 0.8717125940174659 0.9875111685516926 1.0018569349709954 1.0003769353451486 1.0368537133279003 0.847459335681883 0.8053662549259889 0.9169515555643173 0.8340988432290235 1.0 15.026552734802344 -6.771336440186224 24.998854062013546 0.8708715965914428 0.9824821733960277 0.36878306275122985 0.0639811711235898 199.32989690101067 503481.70594081125 0.02191420440798714 0.019556238152328802 1.693025735466854e-07 6.771336440186224 0.11161057680458497 NSDDAPWS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 NSDDAPWSPK 10 0 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;H0Y3N9;Q9UPP1-5;H0Y589 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 NSDDAPWS(1)PK;NSDDAPWS(1)PK 90.229 0.02973 14067200.0 149459.0 141385.0 134276.0 121406.0 125537.0 100468.0 119565.0 120807.0 79653.0 120904.0 True False 141152.66711178163 152228.77487557172 125636.82834865498 104870.2933629684 109765.9197449807 114306.55504230075 125125.00941355276 121158.52836932446 95585.8256907725 117413.1873736821 1.2021875078013655 1.2965219519259337 1.0700401816773792 0.8931730388104159 0.9348687502676933 0.9735410271974467 1.0656810551895404 1.0318988103416555 0.8140978694885328 1.0 16.84123492964924 -5.450462017943953 3.9759014347728434 0.9647450383739214 1.245940867948724 0.7251285629339697 0.0707300690731303 0.1169965358935356 3.5088997417234467 0.01953254246020143 0.042327530846619506 3.544361268161323e-06 5.450462017943953 0.2811958295748026 NSDGGS(ph)DPETQK ddPTM_A459_Selumetinib_30min_R1 1 NSDGGSDPETQK 12 0 O75554-2;O75554 O75554-2 WBP4 WW domain-binding protein 4 1 NSDGGS(0.864)DPET(0.136)QK 141.06 0.0010231 5010500.0 1426.5 3360.2 1521.7 1246.4 1494.3 1714.0 1376.9 2084.5 1902.9 1922.0 True False 1459.7346745141876 2966.7862218854016 1315.0614980997816 1028.7396378256935 1359.1408288400933 1696.758716187484 1273.0393244514505 2029.2122885897434 3229.0823176828844 2168.707421865391 0.6730897214611882 1.3679974495285083 0.6063803189130257 0.4743561198959857 0.6267054814019323 0.7823824915617408 0.5870037201036823 0.9356782146502444 1.4889432687538013 1.0 11.082619718264619 -8.030098829981972 6.342155492156575 1.239482062903602 0.7397770405537027 0.3922738574210164 0.253998662645729 0.2020616663084375 26.692470894035974 0.17163928981429125 0.06761894023100146 9.330419494643618e-09 8.030098829981972 -0.49970502234989933 NSDGGS(ph)DPETQKEK ddPTM_A459_Selumetinib_30min_R1 3 NSDGGSDPETQKEK 14 1 O75554-2;O75554 O75554-2 WBP4 WW domain-binding protein 4 1 NS(0.008)DGGS(0.93)DPET(0.063)QKEK;NSDGGS(1)DPETQKEK;NSDGGS(0.987)DPET(0.013)QKEK 199.61 0.000379 17046500.0 5518.91 7915.199999999999 8522.3 7843.5 5718.5 8966.0 5463.76 8280.7 8902.9 6388.4 True False 5647.489865070519 6988.484704323348 7365.018469643011 6473.779965729961 5201.262684683178 8875.810180476656 5051.624184301585 8061.068936495611 15107.571057911064 7208.41336828557 0.7834581032654767 0.9694900038710558 1.0217253219753526 0.8980866710852443 0.721554441864678 1.2313125964067255 0.7007955740339361 1.1182861643259 2.0958247378513213 1.0 12.815466029897333 -8.014230780710486 24.315879971145858 1.5676269095079836 0.915732780147096 0.4425220998530315 0.2857655223536556 361.8199507036333 618230.8059422406 0.16229903217445174 0.06664083061662154 9.677634576238583e-09 8.014230780710486 -0.6518941293608875 NSDGGS(ph)DPETQKEK ddPTM_A459_Selumetinib_30min_R2 2 NSDGGSDPETQKEK 14 1 O75554-2;O75554 O75554-2 WBP4 WW domain-binding protein 4 1 NSDGGS(0.927)DPET(0.072)QKEK;NSDGGS(0.988)DPET(0.012)QKEK 118.71 0.011009 8472800.0 58543.0 48644.0 35944.0 44914.0 37430.0 37110.0 71192.0 127052.0 40982.0 109183.0 True False 55289.4144261973 52374.83838488747 33631.40217286817 38796.635719028425 32727.708771554404 42221.5656489607 74502.5690642718 127421.70028540914 49179.54513275375 106030.60309849787 0.5214477029319149 0.49395963857937786 0.3171858047588963 0.3659003588142191 0.3086628559601021 0.398201692861623 0.7026515636722552 1.2017445582860626 0.46382406301195955 1.0 16.694121197397834 -7.397338896421599 3.7975030887327352 0.8861932719392985 0.3959105273118703 0.5915828899205943 0.1834326715422154 0.15897474890103744 4.038587084786084 0.07852942224702442 0.05037650243211033 4.0055402817293256e-08 7.397338896421599 -0.4902827446274282 NSDLLT(ph)SPDVGLLK ddPTM_A459_Selumetinib_30min_R1 1 NSDLLTSPDVGLLK 14 0 P05412 P05412 JUN Transcription factor AP-1 1 NS(0.019)DLLT(0.867)S(0.114)PDVGLLK 152.25 0.00090334 21091000.0 3297.2 2541.5 2765.2 2682.9 2513.7 2363.8 2297.0 2379.9 1551.8 1860.2 True False 3374.018344765637 2243.939998488704 2389.7010281563503 2214.381879270341 2286.336278829779 2340.022318158678 2123.7354406746917 2316.7773209953134 2633.291261012297 2098.974789882415 1.607460156753312 1.0690647688124022 1.1385086851330035 1.0549825990975294 1.0892633345814793 1.1148406019158366 1.0117965451093693 1.1037661491518438 1.2545606901547468 1.0 11.035469123645639 -4.759716162320389 24.9988900918677 1.0944845995612196 1.6074607954355744 0.8379631445717911 0.06786862743924851 16.256088118481955 235759.05612763076 0.016358980053991782 0.10181100036881233 1.7389369577953828e-05 4.759716162320389 0.5129761958743548 NSDLLT(ph)SPDVGLLK ddPTM_A459_Selumetinib_30min_R2 2 NSDLLTSPDVGLLK 14 0 P05412 P05412 JUN Transcription factor AP-1 1 NSDLLT(0.964)S(0.036)PDVGLLK;NS(0.006)DLLT(0.86)S(0.134)PDVGLLK 137.91 0.0013637 5577400.0 54592.0 54083.0 47124.0 52134.0 51576.0 43876.0 45570.0 38942.0 35316.0 52542.0 True False 51557.99518909117 58230.99219574605 44092.0931447318 45033.25926383371 45096.56178470986 49919.52073332792 47689.09529524194 39055.31477280487 42380.18681148628 51024.97593948933 1.0104462420567124 1.14122527494775 0.8641276616577094 0.8825728662221963 0.8838134845607768 0.9783350175907505 0.9346225925083547 0.765415643098405 0.8305773012366545 1.0 15.638915976513713 -5.2692580972024885 24.980969090232048 0.8879697562240019 1.0758357614855392 0.515793756052884 0.070973925218832 406.3799192515263 1298395.566756943 0.019073077398956292 0.0408577880736214 5.379499887868773e-06 5.2692580972024885 0.1878660052615373 NSESESNKVAAETQS(ph)PSLFGSTK ddPTM_A459_Selumetinib_30min_R1 2 NSESESNKVAAETQSPSLFGSTK 23 1 Q9UKX7-2;Q9UKX7 Q9UKX7-2 NUP50 Nuclear pore complex protein Nup50 1 NSESESNKVAAETQS(0.833)PS(0.164)LFGS(0.002)TK;NSESESNKVAAET(0.003)QS(0.854)PS(0.14)LFGS(0.003)T(0.001)K 119.85 5.8465e-06 12119900.0 2626.5299999999997 2174.86 4674.0 4601.9 3074.9 2964.0 2513.39 3024.9 2182.84 1835.7 True False 2687.7230386622846 1920.226380135017 4039.2964724442268 3798.2645533617283 2796.775837917688 2934.1848510966756 2323.802968758103 2944.6698257400426 3704.12005167424 2071.329976232206 1.2975832288930182 0.927049964114337 1.9500980137369492 1.8337322381974377 1.3502319137992123 1.416570457032646 1.1218893152819382 1.4216324098666602 1.7882810050439741 1.0 11.01634168715942 NSFLGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 NSFLGSPR 8 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5;H0YES6;J3KNK0;Q8TDC3;Q8TDC3-2 Q8IWQ3-6 BRSK2;BRSK1 Serine/threonine-protein kinase BRSK2;Serine/threonine-protein kinase BRSK1 1 NSFLGS(1)PR 96.113 0.021341 14779000.0 3027.9 3744.5 3674.3 3802.4 2777.7 3177.4 3102.9 2823.5 1917.1 2750.2 True False 3098.4441787322157 3306.092199229178 3175.3502414851987 3138.382219888012 2526.457525442766 3145.4382408483725 2868.8457548408783 2748.6116079794406 3253.1786805559173 3103.2149592165474 0.9984626329316432 1.0653764701056512 1.02324533853332 1.0113325248600706 0.8141419652348568 1.0136063025561353 0.9244753562173987 0.885730329385035 1.0483252766277043 1.0 11.599547920250748 -6.0229359886539955 24.93894091780292 0.9412783692767258 1.0301006675701838 0.25246907894924975 0.06477849523861051 899.6406448309641 978203.2510374394 0.01820911731034632 0.02368537931576958 9.485582624906142e-07 6.0229359886539955 0.088822298293458 NSFLGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 NSFLGSPR 8 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5;H0YES6;J3KNK0;Q8TDC3;Q8TDC3-2 Q8IWQ3-6 BRSK2;BRSK1 Serine/threonine-protein kinase BRSK2;Serine/threonine-protein kinase BRSK1 1 NSFLGS(1)PR;NSFLGS(1)PR 103.08 0.015702 20581600.0 144310.0 124572.0 123376.0 139233.0 141060.0 100977.0 113636.0 120604.0 77253.0 112149.0 True False 136289.82791870146 134126.2718378879 115438.12248163203 120269.22520967807 123338.78170759974 114885.66517205878 118920.29916546219 120954.93767293301 92705.75862916929 108910.96697190392 1.2513875480865075 1.2315221833673449 1.059931113378251 1.1042893893385803 1.1324734793642757 1.054858554342798 1.0919038042894285 1.1105854721144484 0.8512068270689843 1.0 16.732789710395593 -1.5228787453001436 0.21361704280869293 0.9711202012880377 2.4262420386068686 0.580849592048148 0.06965608399270358 38.86510177151335 0.4886649401556991 0.11488280248447083 19.31478833000661 0.02999999999863185 1.5228787453001436 1.4551218373188308 NSGEPLPPKPGPGS(ph)PSHPGALDLDGVSR ddPTM_A459_Selumetinib_30min_R1 3 NSGEPLPPKPGPGSPSHPGALDLDGVSR 28 1 A1X283;G3V144;A0A1B0GUF2 A1X283 SH3PXD2B SH3 and PX domain-containing protein 2B 1 NSGEPLPPKPGPGS(0.983)PS(0.017)HPGALDLDGVSR;NSGEPLPPKPGPGS(0.923)PS(0.071)HPGALDLDGVS(0.006)R;NSGEPLPPKPGPGS(0.804)PS(0.176)HPGALDLDGVS(0.02)R 93.126 2.5254e-06 51546000.0 6921.5 7594.8 10984.5 12127.3 8778.2 8387.1 7863.700000000001 7267.6 4688.3 5986.8 True False 7082.757483105467 6705.597285273271 9492.865233539505 10009.494712615155 7984.213359917082 8302.73338887751 7270.534777898809 7074.839639508188 7955.702680115968 6755.264096370308 1.0484797310753735 0.9926476877308582 1.405254494585955 1.4817325525427478 1.1819246806660164 1.2290760613398783 1.0762769114837958 1.0473076312900325 1.1777041676861564 1.0 12.721796457333088 -7.260102743583265 20.322687429200673 1.0792644991827027 1.230859332601923 0.20429333439365116 0.1423935846939312 16.466957561566964 250400.05558454557 0.06276733502956786 0.04581676274371351 5.494108811391789e-08 7.260102743583265 0.1515948334192203 NSGEPLPPKPGPGS(ph)PSHPGALDLDGVSR ddPTM_A459_Selumetinib_30min_R2 7 NSGEPLPPKPGPGSPSHPGALDLDGVSR 28 1 A1X283;G3V144;A0A1B0GUF2 A1X283 SH3PXD2B SH3 and PX domain-containing protein 2B 1 NSGEPLPPKPGPGS(0.938)PS(0.062)HPGALDLDGVSR;NSGEPLPPKPGPGS(0.499)PS(0.499)HPGALDLDGVS(0.002)R;NSGEPLPPKPGPGS(0.791)PS(0.208)HPGALDLDGVS(0.001)R;NSGEPLPPKPGPGS(0.798)PS(0.202)HPGALDLDGVSR;NSGEPLPPKPGPGS(0.733)PS(0.267)HPGALDLDGVSR;NSGEPLPPKPGPGS(0.87)PS(0.13)HPGALDLDGVSR;NSGEPLPPKPGPGS(0.943)PS(0.057)HPGALDLDGVSR 90.78 7.7246e-06 74520600.0 207216.0 199346.0 214057.0 221645.0 224556.0 172408.2 183555.7 189776.0 142552.2 226259.0 True False 195699.76427137124 214635.19720158225 200284.8056676398 191456.56864104862 196345.26772388897 196155.86458418606 192091.40375871916 190328.21674089206 171066.6232412609 219726.3147785181 0.8906523757458664 0.976829732105289 0.9115194321150147 0.8713410991943996 0.893590136992936 0.8927281412875339 0.8742303076094702 0.8662058385348199 0.7785440875103846 1.0 17.74534813403438 -5.5836994011898184 4.564354165382732 0.87763918931185 0.9362092342038235 0.12508703178039948 0.05405671234114202 0.3377769568489377 14.175184930792764 0.014177562065977964 0.025874285276667536 2.607958034906387e-06 5.5836994011898184 0.05857004489197348 NSGEPLPPKPGPGSPS(ph)HPGALDLDGVSR ddPTM_A459_Selumetinib_30min_R1 1 NSGEPLPPKPGPGSPSHPGALDLDGVSR 28 1 A1X283;G3V144;A0A1B0GUF2 A1X283 SH3PXD2B SH3 and PX domain-containing protein 2B 1 NSGEPLPPKPGPGS(0.185)PS(0.805)HPGALDLDGVS(0.01)R 65.248 0.027291000000000003 0.0 721.69 574.49 659.0 741.56 638.75 684.98 664.13 591.65 377.13 476.67 True False 738.5039728357125 507.22844372684466 569.5114196278873 612.0604668052159 580.9751752804716 678.0897231120784 614.0341394058692 575.9575200499503 639.9620655146074 537.8552376589892 1.373053418704344 0.9430575519438141 1.0588563236953525 1.1379650581617546 1.080170154722601 1.2607290505591409 1.1416345819712532 1.0708411478092155 1.189840724244013 1.0 9.0710741171767 -10.568505017709812 4.159850061862096 0.9999883431975303 1.131226406454299 0.11851497802054567 0.11213326157755366 14789123.3153189 12531958.89365395 1604.3809832433105 0.0260540234986628 2.7008159037173877e-11 10.568505017709812 0.13123806325676868 NSGSFPS(ph)PSISPR ddPTM_A459_Selumetinib_30min_R2 1 NSGSFPSPSISPR 13 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 NSGS(0.001)FPS(0.97)PS(0.029)ISPR 115.09 0.0040713 5214000.0 22698.0 21885.0 24827.0 29565.0 33760.0 21153.0 19732.0 22451.0 19980.0 24743.0 True False 21436.5360272932 23563.5091286338 23229.657849593772 25538.19599753027 29518.766981770674 24066.633742184462 20649.57709821623 22516.328693036878 23976.558287843927 24028.60529996544 0.8921256876829232 0.980644062960562 0.9667501529781749 1.062824732385404 1.2284844090311446 1.0015826321063703 0.85937476771679 0.9370634879532215 0.9978339561754928 1.0 14.552465291636974 -10.269940153718977 12.202285313543467 0.999999125544249 0.9946110562620362 0.0 0.09616858877217718 0.0 0.0 0.10287878136613886 0.02495176954161274 5.3710580507095e-11 10.269940153718977 -0.005388069282212804 NSGSFPSPS(ph)ISPR ddPTM_A459_Selumetinib_30min_R2 1 NSGSFPSPSISPR 13 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 NS(0.007)GS(0.002)FPS(0.281)PS(0.71)ISPR 115.09 0.0040713 4765700.0 35834.0 29510.0 44512.0 50038.0 55412.0 36991.0 32997.0 38045.0 38991.0 36242.0 True False 33842.489734867624 31773.322110394518 41648.14638100123 43222.738079635405 48450.649170434765 42086.17447913516 34531.42588231508 38155.7046513112 46790.28949956569 35195.59929197539 0.961554581131503 0.9027640599840232 1.1833339172746242 1.2280722291746913 1.3766110009520858 1.1957794532775812 0.9811290779807309 1.0841044169976874 1.3294357942708448 1.0 15.103107431237436 -5.265010775871069 24.42818681106089 1.1786105034908165 0.9321593036058282 0.3859948224513572 0.12094470042285638 214.747337893073 1468879.057846542 0.033198069696905225 0.07383131435373068 5.432368523368162e-06 5.265010775871069 -0.24645119988498831 NSGSFPSPSIS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 NSGSFPSPSISPR 13 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 NSGSFPSPSIS(1)PR;NSGSFPSPSIS(1)PR 166.79 0.0003229 96664000.0 4828.6 6627.9 5984.5 6950.3 5904.6 4978.1 6502.1 6493.7 2883.7 5165.5 True False 4941.096985179956 5851.902386772887 5171.837770505454 5736.560578289403 5370.529972541799 4928.024833753156 6011.641362129257 6321.465981489671 4893.428282885139 5828.542241230843 0.8477414730267993 1.0040078881777328 0.8873295511045812 0.9842187533118031 0.9214190702009354 0.8454986907176433 1.031414222170885 1.0845706730530162 0.8395629782468161 1.0 12.508919385184727 -7.2824437351276075 24.944547772033946 0.9959345234778549 0.9212555164232379 0.18253646020831282 0.07529309660062336 1385.9601836777922 1645943.9348935594 0.03043874297129303 0.020543424775348373 5.218627096036593e-08 7.2824437351276075 -0.07467900705461705 NSGSFPSPSIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 NSGSFPSPSISPR 13 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 NSGSFPSPSIS(1)PR 197.73 0.00016469 52826000.0 57900.0 50471.0 61330.0 56071.0 50599.0 36313.0 41543.0 48376.0 38334.0 47791.0 True False 54682.149792064345 54341.9634101566 57384.09457105512 48434.03307212989 44242.30125920067 41314.78613340635 43474.83181589282 48516.7661509221 46001.871141451906 46411.14965406976 1.1782114901191487 1.1708816483797528 1.2364290692812678 1.0435861518867318 0.953268806934652 0.8901909657776271 0.9367324907901855 1.0453687640264626 0.9911814614447507 1.0 15.502183814607271 -5.92898329492031 3.9439257650813806 0.967777780961066 1.1918642902632008 0.8493820235324876 0.042382555061750364 0.08715350793624665 2.692163087858615 0.013727517781442815 0.020848998189477014 1.1776512708496846e-06 5.92898329492031 0.2240865093021348 NSGTQS(ph)DGEEKQPGLVMER ddPTM_A459_Selumetinib_30min_R1 1 NSGTQSDGEEKQPGLVMER 19 1 J3QRV5;Q6P1M3;Q6P1M3-2 J3QRV5 LLGL2 Lethal(2) giant larvae protein homolog 2 1 NS(0.002)GT(0.135)QS(0.863)DGEEKQPGLVMER 77.83800000000002 0.0043252 13844000.0 1860.5 2108.4 2520.3 2693.0 2362.2 1757.6 2333.5 2084.6 1235.4 1777.1 True False 1903.846030097194 1861.5475478314324 2178.0571030169413 2222.7181038708222 2148.5394270802826 1739.9201397731165 2157.4822162883725 2029.309636264899 2096.3835699539845 2005.2080954198693 0.9494506003869633 0.9283562898451415 1.086200034795331 1.1084725365650434 1.0714795297245203 0.8677005362921176 1.0759393108457498 1.0120194711462018 1.0454693329547047 1.0 10.969536248350659 -5.244532621721662 24.636858208564377 1.0334804875517056 0.9389034235501973 0.2580842734817952 0.06409412463116292 978.6044086031039 1426035.4357690439 0.016977672247260635 0.04464488767969766 5.694654475286091e-06 5.244532621721662 -0.09457706400150834 NSITEIS(ph)DNEDDLLEYHR ddPTM_A459_Selumetinib_30min_R1 1 NSITEISDNEDDLLEYHR 18 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 NSIT(0.009)EIS(0.991)DNEDDLLEYHR 144.43 0.00018842 1736100.0 921.72 901.8 724.86 994.58 821.11 726.7 913.55 882.55 523.69 874.32 True False 943.1942826450869 796.2168367645539 626.4279933709722 820.8952735788491 746.8407454787454 719.3900577908075 844.6401879966756 859.1419070735808 888.6636811957278 986.5474885979963 0.9560556319346374 0.8070740090738812 0.6349699336432374 0.8320889597980132 0.7570246279174018 0.7291996240476453 0.8561576586617354 0.8708571224427581 0.9007814539760541 1.0 9.946244688180082 -8.218366430623785 1.0156251737323232 0.9920381900158296 0.7825871684322824 0.4134848452703421 0.07885240551116837 0.4966309130001405 1.0344488725835055 0.07597136542627533 0.02637310874275816 6.048303412498765e-09 8.218366430623785 -0.20945102158354723 NSITEIS(ph)DNEDDLLEYHR ddPTM_A459_Selumetinib_30min_R2 2 NSITEISDNEDDLLEYHR 18 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 NSITEIS(1)DNEDDLLEYHR;NSITEIS(1)DNEDDLLEYHR 176.1 1.5445999999999998e-09 4213700.0 32688.0 28177.0 43143.0 43905.0 39803.0 27093.5 28615.0 30639.0 24821.3 36497.0 True False 30871.331820431787 30338.085296665053 40367.22635054671 37925.0632596505 34802.59129666523 30825.3836946946 29945.654199546807 30728.15441744049 29786.25356506809 35443.23677940584 0.8710076907639954 0.8559626053761796 1.138926069359499 1.070022568640986 0.9819247466948942 0.8697113044880138 0.8448905043838044 0.8669680652669672 0.8403931545658179 1.0 15.113222740563321 -6.746513092005017 6.943899057217811 0.8734151859253834 0.9903192598854436 0.23195431617559137 0.0887427431880022 0.21861286686877388 46.815461682953305 0.03226059231804857 0.0310492183895772 1.7926145123698293e-07 6.746513092005017 0.1169040739600602 NSKYEYDPDIS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 3 NSKYEYDPDISPPR 14 1 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 NSKYEYDPDIS(1)PPR;NSKYEYDPDIS(1)PPR;NSKYEYDPDIS(1)PPR 110.6 0.013876 22257800.0 178485.0 249813.0 227482.0 227068.0 200263.0 113695.1 108936.0 95177.1 70550.0 223859.0 True False 168565.51823206586 268972.8538246008 212846.0557836746 196140.9466858517 175104.17156606453 129355.56800364183 114001.73985258878 95454.04960358288 84661.97133170108 217395.60901446771 0.7753860300869637 1.2372506282162332 0.9790724695341462 0.9022304892680628 0.8054632398504945 0.595023830472276 0.5243976194799866 0.4390799337498597 0.38943735669503243 1.0 17.729963275349284 -6.50327310774691 1.5213942653484562 0.538663043408158 1.0130979470304868 0.47292239592060836 0.18913714040860294 0.29348883002545223 1.3846071185868647 0.07269363834877368 0.0815032414727757 3.138534393804063e-07 6.50327310774691 0.4744349036223289 NSLDAS(ph)RPAGLSPTLTPGER ddPTM_A459_Selumetinib_30min_R2 1 NSLDASRPAGLSPTLTPGER 20 1 A0A075B6E4;A0A0A6YYI5;G5E9M7;Q14135-2;Q14135;Q14135-4;F8W708;E7ERW0;E7EQU6;E7EWF5;G5E9M9;Q14135-5;Q14135-6 A0A075B6E4 VGLL4 Transcription cofactor vestigial-like protein 4 1 NS(0.003)LDAS(0.655)RPAGLS(0.194)PT(0.038)LT(0.109)PGER 56.017 0.023554 9226300.0 31004.0 29107.0 29815.0 37207.0 29059.0 22727.0 21141.0 25871.0 15854.0 24047.0 True False 29280.921798845644 31339.41330624372 27896.735360117527 32139.34241434497 25408.3486292439 25857.43795483507 22124.098390096773 25946.2803268254 19025.24299777164 23352.70062839062 1.2538559143454227 1.342003813817722 1.1945828366507032 1.3762580579340855 1.0880261359730774 1.1072568593372607 0.9473892866677615 1.1110612318337898 0.8146913412936081 1.0 14.511301779929365 -6.677671030858806 1.2927935085016056 0.972280148048807 1.292615450756943 0.7067622418887849 0.09012317305954032 0.2297960197415533 0.8065007592477759 0.039245504225457625 0.03822078500046197 2.1005303897441502e-07 6.677671030858806 0.3203353027081359 NSLDASRPAGLS(ph)PTLTPGER ddPTM_A459_Selumetinib_30min_R1 1 NSLDASRPAGLSPTLTPGER 20 1 A0A075B6E4;A0A0A6YYI5;G5E9M7;Q14135-2;Q14135;Q14135-4;F8W708;E7ERW0;E7EQU6;E7EWF5;G5E9M9;Q14135-5;Q14135-6 A0A075B6E4 VGLL4 Transcription cofactor vestigial-like protein 4 1 NSLDAS(0.014)RPAGLS(0.981)PT(0.005)LTPGER 101.23 0.0033834000000000004 10544000.0 806.99 962.07 933.0 1131.0 827.88 821.84 881.06 669.37 407.91 723.58 True False 825.7912968708057 849.4303971457914 806.3037246021536 933.4920814994049 752.9984001740854 813.5730357710163 814.6009348545249 651.6161331798116 692.1934774323537 816.458541266056 1.0114307771099775 1.0403839928339864 0.987562360915282 1.143342906367136 0.922273896487671 0.9964658272904277 0.9977248000753955 0.7981006998461568 0.8477999095446922 1.0 9.673235819188843 -7.660084566467492 6.787065172253676 0.8680012742362051 1.0161860979904633 0.42255178607001986 0.07045076115250393 0.18217632313962426 10.539073350655409 0.03269764555890304 0.018652998125049298 2.1873356612254232e-08 7.660084566467492 0.14818482375425823 NSLEDNSWVFPS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 NSLEDNSWVFPSPPK 15 0 Q9H6S1 Q9H6S1 AZI2 5-azacytidine-induced protein 2 1 NSLEDNSWVFPS(1)PPK 139.29 0.00042866 0.0 17999.0 12984.0 14399.0 13117.0 14240.0 11056.0 11443.0 13957.0 12802.0 14721.0 True False 16998.68763570581 13979.831049859786 13472.584016445822 11330.441971912887 12451.04389278479 12578.863643624618 11975.122173874344 13997.612559294268 15362.757717766663 14295.966480248604 1.1890548050172964 0.9778863897851472 0.9424045611088714 0.7925621529378302 0.8709480334881331 0.8798889995302979 0.8376574043048609 0.9791302028186382 1.074621833997159 1.0 13.803320536358516 -4.7085749643736925 2.082744425369394 0.9106451316107551 1.3031688697861055 0.5030403629550245 0.07889154148261396 0.7605958724004667 3.1431492639563645 0.022278444094709506 0.6081645560006549 1.9562530663305114e-05 4.7085749643736925 0.39252373817535036 NSLESISS(ph)IDRELSPEGPGK ddPTM_A459_Selumetinib_30min_R1 1 NSLESISSIDRELSPEGPGK 20 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 NS(0.001)LES(0.038)IS(0.189)S(0.72)IDRELS(0.052)PEGPGK 69.084 0.006902800000000001 8555300.0 1790.5 2228.6 2321.0 2515.3 2097.6 2105.6 2180.3 1698.7 1062.8 1522.3 True False 1832.2151662934828 1967.6744759519693 2005.8209483404044 2076.0500730286944 1907.872450361358 2084.4195757318357 2015.838215630399 1653.644957844759 1803.4939761592157 1717.7020334576932 1.0666664710207494 1.1455272437391761 1.167735095651447 1.2086206062466232 1.110712110249329 1.2134931059818035 1.1735668796831804 0.9627076906441165 1.0499457653483855 1.0 10.746264081245814 -7.755399546472205 24.999998894936414 1.0047450356878342 1.1578866571196347 0.6994863694462267 0.04532214046595094 75.43372843213632 312238.301927235 0.021899514210458694 0.012225146492064107 1.756307085959672e-08 7.755399546472205 0.15314162143180043 NSLLAGGDDDTMSVIS(ph)GISSR ddPTM_A459_Selumetinib_30min_R1 1 NSLLAGGDDDTMSVISGISSR 21 0 Q8N3U4;Q8N3U4-2 Q8N3U4 STAG2 Cohesin subunit SA-2 1 NSLLAGGDDDTMSVIS(0.931)GIS(0.061)S(0.009)R 210.33 8.158700000000001e-18 11902000.0 2457.8 3742.8 4109.4 3895.1 2753.1 2784.1 3595.4 2968.4 1718.8 2489.2 True False 2515.0619579537115 3304.5912360194866 3551.366051318424 3214.8939050825234 2504.082591099285 2756.0944817605446 3324.1960833268517 2889.6683892779047 2916.678063814884 2808.713066861255 0.895449943829364 1.1765499562802892 1.2644104138722458 1.1446145720663368 0.8915409055641289 0.9812659449904181 1.1835299669971808 1.028822923698332 1.0384393116646409 1.0 11.45569353349088 NSLLAGGDDDTMSVISGIS(ph)SR ddPTM_A459_Selumetinib_30min_R1 3 NSLLAGGDDDTMSVISGISSR 21 0 Q8N3U4;Q8N3U4-2 Q8N3U4 STAG2 Cohesin subunit SA-2 1 NSLLAGGDDDTMSVISGIS(0.895)S(0.105)R;NSLLAGGDDDTMSVIS(0.142)GIS(0.717)S(0.142)R;NSLLAGGDDDTMSVIS(0.186)GIS(0.515)S(0.299)R 230.24 6.3446e-25 24102800.0 2098.46 2489.12 2948.05 2926.53 2588.74 2545.94 2291.4 1660.42 794.34 1798.38 True False 2147.3500351076364 2197.6926732395054 2547.721002479505 2415.466473271844 2354.588924079169 2520.3301551285667 2118.557853183276 1616.380267795721 1347.9369637018356 2029.2195907046228 1.0582147170982092 1.0830235837001665 1.2555176453795416 1.190342575212918 1.1603421013994673 1.2420194278990828 1.0440259215354961 0.7965526625112327 0.6642637247720343 1.0 10.986709278528803 -7.639350158521776 3.473275577641941 0.7957257852891545 1.1653392342811957 0.716247308497792 0.0964289593087887 0.11814857730846347 2.7606606601879657 0.05046545394922428 0.02672002499532086 2.294298078947729e-08 7.639350158521776 0.3696134489920412 NSLLAGGDDDTMSVISGISS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 NSLLAGGDDDTMSVISGISSR 21 0 Q8N3U4;Q8N3U4-2 Q8N3U4 STAG2 Cohesin subunit SA-2 1 NSLLAGGDDDT(0.001)MS(0.01)VIS(0.129)GIS(0.209)S(0.65)R 102.61 0.00020865 4224600.0 1494.9 1597.6 1723.1 2169.9 2565.1 1665.6 1997.9 2030.3 784.64 1214.2 True False 1529.7282614309572 1410.5522492959096 1489.1124843107928 1790.9676990676912 2333.0871579051873 1648.8455762438 1847.196794481482 1976.4498486561567 1331.4767721618045 1370.0543973095525 1.116545638213318 1.0295593022188643 1.0869002626720814 1.3072237880369628 1.7029157108555635 1.2034891311481677 1.3482652937787862 1.4426068428650822 0.9718422675599561 1.0 10.420017460454261 -5.757446797557099 6.17497184920354 1.3183829428285152 1.0709630628029467 0.16406945575358478 0.20067697052970027 0.2199079589318602 32.86232161945014 0.05481408312476815 0.08945724721792854 1.7480473906173417e-06 5.757446797557099 -0.24741988002556847 NSMVLDVAFVLEGSDK ddPTM_A459_Selumetinib_30min_R1 1 NSMVLDVAFVLEGSDK 16 0 P04275 P04275 VWF von Willebrand factor;von Willebrand antigen 2 0 85.28 0.023083000000000003 10263000.0 2146.8 2809.7 3130.9 3468.8 2588.5 2896.5 2706.6 2688.7 1464.9 2159.5 False True 2196.8162630543698 2480.739017805907 2705.740976802659 2863.0391974404397 2354.370632036792 2867.3638398115795 2502.4389829038396 2617.3869418715476 2485.8283079371777 2436.6928603112965 0.9015564902889396 1.0180762041092795 1.1104152767357764 1.1749692561066871 0.96621559096948 1.1767440560585314 1.0269817028085122 1.0741554606669494 1.0201648096180673 1.0 11.25070869869789 -4.845639154016576 3.1011619947264024 1.0736001852926127 0.8872845790951185 0.3632276076005917 0.06667548141302788 0.3134368476641983 4.840246620232835 0.01625275711292755 0.1332354670939289 1.4267925926454654e-05 4.845639154016576 -0.1863156061974942 NSNLVGAAHEELQQSR ddPTM_A459_Selumetinib_30min_R1 1 NSNLVGAAHEELQQSR 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 178.02 1.5922e-06 10562000.0 4754.2 5499.7 6938.2 7062.4 5338.6 5382.1 4982.0 4905.1 2864.2 3883.5 False True 4864.963609937156 4855.792567258838 5996.030548804565 5829.084417667023 4855.724572606382 5327.960960555807 4606.203728968788 4775.000813989711 4860.338207108788 4381.985053493367 1.1102191245629087 1.1081262277213262 1.3683366044401415 1.3302383158564206 1.1081107108604455 1.2158783965518773 1.0511682885126847 1.0896889778715761 1.1091635749040434 1.0 12.097368848112136 -7.123225935194329 1.5926155686125762 1.0652344765547372 1.2203721001269108 0.3695550631469777 0.08953336596767564 0.4770346371187565 2.398950016470017 0.05046133441486731 0.03417349637835066 7.52963743722231e-08 7.123225935194329 0.15513762357217353 NSNLVGAAHEELQQSR ddPTM_A459_Selumetinib_30min_R2 2 NSNLVGAAHEELQQSR 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 197.51 1.4799e-06 21801000.0 89667.0 70740.0 84981.0 101169.0 82393.0 57593.0 53800.0 61045.0 51232.0 73956.0 False True 84683.66710544098 76165.5305350495 79513.41498031703 87389.60767374058 72042.05473723434 65525.91297279961 56301.80660267755 61222.63084345619 61479.83154168266 71820.69811923562 1.179098356365883 1.0604955469605803 1.1071100262532965 1.2167746897789506 1.0030820727700422 0.9123541637539432 0.7839217395131158 0.8524371448160434 0.856018294887844 1.0 16.1321120560589 -6.61760685603547 2.664336774323408 0.8620530748718075 1.1321565459567726 0.7731344843150733 0.06582720969203573 0.12159739323766883 1.7511353492772792 0.023050940504621906 0.02324603922574314 2.4120879771117146e-07 6.61760685603547 0.27010347108496513 NSNPVIAELSQAINSGTLLSKPS(ph)PPLPPKR ddPTM_A459_Selumetinib_30min_R1 2 NSNPVIAELSQAINSGTLLSKPSPPLPPKR 30 2 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 NSNPVIAELSQAINS(0.004)GT(0.005)LLS(0.004)KPS(0.987)PPLPPKR;NSNPVIAELSQAINS(0.007)GT(0.003)LLS(0.025)KPS(0.965)PPLPPKR 101.08 1.4606e-08 39269000.0 1971.07 2137.2200000000003 2811.54 2954.13 1940.29 2100.89 2014.52 2099.27 1303.65 1843.44 True False 2016.9920959654248 1886.9932888333772 2429.7483106837485 2438.2466513880104 1764.7911120860222 2079.756954055498 1862.5631345006427 2043.5905402100216 2212.1988351712093 2080.06348062619 0.9696781443219329 0.907180625211164 1.1681125760413273 1.1721981920734417 0.8484313716977248 0.9998526359538799 0.895435717154137 0.9824654676379451 1.0635246740187183 1.0 11.022411842733785 -6.263915228430563 24.994877683991703 0.9623441771492149 1.0519144106342604 0.18064278132882128 0.09305963690386929 430.7713136912697 4348832.468290551 0.030260609035487995 0.035934137002518164 5.446089467318691e-07 6.263915228430563 0.08957023348504545 NSNS(ph)PPS(ph)PSSMNQR ddPTM_A459_Selumetinib_30min_R1 2 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 2 NS(0.168)NS(0.832)PPS(0.992)PS(0.006)S(0.001)MNQR;NS(0.003)NS(0.997)PPS(0.983)PS(0.014)S(0.003)MNQR 167.92 0.0037435 11723200.0 2634.5 3491.7 3276.2 3607.8 3212.3 3031.4 3632.1 3336.1 1733.9 2935.7 True False 2695.878724155365 3082.890140752711 2831.3100348784305 2977.765456793593 2921.7480321776266 3000.906868290978 3358.1277727795155 3247.615790819977 2942.3016609545207 3312.525691139559 0.8138438688540229 0.9306765979201055 0.8547284757524151 0.8989410904068178 0.8820303009250023 0.9059271227142152 1.0137665593845608 0.9804047103715438 0.8882351218662773 1.0 11.693715928458767 -7.0664272752588015 5.303821151293008 0.9687466897067007 0.8802966623111677 0.530057500243168 0.04196710136102386 0.18108448062544574 9.88522639338765 0.01564805318282669 0.012216129835863171 8.581688072673303e-08 7.0664272752588015 -0.08845002739553309 NSNS(ph)PPS(ph)PSSMNQR ddPTM_A459_Selumetinib_30min_R2 4 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 2 NS(0.005)NS(0.995)PPS(0.994)PS(0.005)S(0.001)MNQR;NS(0.003)NS(0.997)PPS(0.999)PS(0.001)SMNQR;NS(0.002)NS(0.998)PPS(0.999)PS(0.001)SMNQR;NS(0.018)NS(0.982)PPS(0.984)PS(0.013)S(0.003)MNQR 182.7 4.987899999999998e-13 27879600.0 145654.0 121343.0 144912.0 156998.0 147646.0 111317.0 113901.0 139631.0 101580.0 130374.0 True False 137559.13377915975 130649.61792075932 135588.5196882563 135614.60156334346 129097.3895080127 126649.90631488427 119197.62219054968 140037.30309284353 121898.83838234172 126609.76386766722 1.0864812442343454 1.0319079187077118 1.070916772500845 1.0711227745838632 1.0196479763041462 1.000317056489095 0.9414567925040542 1.1060545317753756 0.9627917678588409 1.0 16.95002914097477 -6.383615227782025 3.9655568657925007 1.0053730647842112 1.063067176715243 0.3314208222673418 0.042155277685898676 0.30750930998515025 8.363615568694868 0.01318210984927415 0.015039089079749657 4.1341361216242044e-07 6.383615227782025 0.05769411193103191 NSNS(ph)PPSPSSMNQR ddPTM_A459_Selumetinib_30min_R2 5 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 NS(0.19)NS(0.81)PPSPSSMNQR;NSNS(0.498)PPS(0.498)PS(0.004)S(0.001)MNQR;NS(0.001)NS(0.996)PPS(0.001)PS(0.001)S(0.001)MNQR;NS(0.003)NS(0.996)PPSPSSMNQR;NSNS(0.999)PPS(0.001)PSSMNQR 185.86 8.0918e-05 165693100.0 334253.0 306325.3 343227.6 309964.1 316320.7 248272.4 452491.9 1196985.9 327743.0 673954.1 True False 315676.55638077523 329819.46551891585 321144.7098939557 267746.45486210316 276581.6657230627 282469.6695075458 473533.66994569043 1200468.9307973157 393300.75790454564 654495.2939899538 0.4823205900478495 0.5039294683209417 0.4906753537312448 0.4090884339746115 0.4225877072957351 0.4315839580534579 0.7235096635438283 1.8341903170593956 0.6009222090916709 1.0 19.320023293250927 -7.53314434519703 24.923315546214496 1.1863039465605438 0.466747084470483 0.5392562278140522 0.2838743260655426 138.5715968332658 336425.82326291327 0.12190354112831729 0.0704767343946519 2.929919274631993e-08 7.53314434519703 -0.7195568620900608 NSNSPPS(ph)PSSMNQR ddPTM_A459_Selumetinib_30min_R1 2 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 NSNS(0.001)PPS(0.973)PS(0.025)S(0.002)MNQR;NSNSPPS(0.914)PS(0.079)S(0.007)MNQR 273.44 1.2429e-44 68145500.0 6079.5 6771.88 6555.34 7308.3 6096.4 5684.05 6751.7 5709.070000000001 3413.08 5664.290000000001 True False 6221.140521352265 5979.025141438396 5665.16083390512 6032.042598781698 5544.9816964068405 5626.873617704473 6242.413833175147 5557.646917927106 5791.74747849971 6391.356796356877 0.9733677401484397 0.9354860527965653 0.8863784348785387 0.9437812331522486 0.8675750506633464 0.880387967217201 0.976696190194447 0.8695566677008251 0.9061843459906748 1.0 12.641906512484095 -10.336443644614848 4.811761597406058 1.000000110753698 0.9140618427744515 0.3009648869062971 0.03858312876714545 24287178.013436552 43.04562735785905 45.219030239339006 0.009494087488551227 4.6084656567551867e-11 10.336443644614848 -0.08593826797924653 NSNSPPS(ph)PSSMNQR ddPTM_A459_Selumetinib_30min_R2 6 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 NSNSPPS(0.885)PS(0.087)S(0.027)MNQR;NS(0.086)NS(0.002)PPS(0.396)PS(0.396)S(0.12)MNQR;NSNS(0.002)PPS(0.731)PS(0.049)S(0.218)MNQR;NSNS(0.007)PPS(0.948)PS(0.044)S(0.002)MNQR;NSNSPPS(0.915)PS(0.074)S(0.011)MNQR;NSNS(0.003)PPS(0.848)PS(0.115)S(0.034)MNQR 158.14 0.00030801 28556900.0 50989.8 49349.3 55512.0 56767.2 58998.2 39090.2 45608.7 46434.700000000004 34293.799999999996 50160.4 True False 48155.991044342016 53134.23262699056 51940.41835689569 49035.40943111792 51586.31866539996 44474.520224494845 47729.594921924516 46569.81728932162 41153.518248831926 48712.13891962928 0.9885829715626969 1.090780117757862 1.0662725864407798 1.0066363440131834 1.0590033574693327 0.9130069262175875 0.9798295862284784 0.9560207850071559 0.844830860675849 1.0 15.571993711957806 -6.757860948399097 24.999990294711445 0.9385571722625177 1.0443064104693758 0.5421791157493445 0.04754314950263435 71.05380163333757 496403.1782635152 0.015671390329293013 0.01508376405808589 1.7463812165113211e-07 6.757860948399097 0.10574923820685811 NSNSPPSPS(ph)SMNQR ddPTM_A459_Selumetinib_30min_R2 1 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 NSNS(0.001)PPS(0.286)PS(0.662)S(0.05)MNQR 172.32 0.00012484 12807000.0 26109.0 16275.0 21396.0 22242.0 22921.0 17726.0 20895.0 19643.0 14068.0 18205.0 True False 24657.966302608085 17523.24016762692 20019.4046542034 19212.601230409884 20041.45906366012 20167.595599393087 21866.658902657015 19700.15787792629 16881.993092762168 17679.374347729496 1.3947307080906304 0.9911685686930075 1.1323593392191749 1.0867240464805983 1.1336068047133117 1.1407414766339368 1.2368457430997992 1.1143017558455803 0.9548976542221511 1.0 14.10977959990101 -14.167264027769242 0.02425276712928546 6.7452063876805975e-06 1.8657594175317107 0.22804718794517498 0.10734592429685327 3857.0256421791873 7.449260740035804 403.4150462214479 201.5835706323826 6.803556131893746e-15 14.167264027769242 1.865752672325323 NSNSPPSPSS(ph)MNQR ddPTM_A459_Selumetinib_30min_R1 1 NSNSPPSPSSMNQR 14 0 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 NSNS(0.004)PPS(0.301)PS(0.209)S(0.486)MNQR 158.14 0.00030801 3076100.0 1394.7 1730.7 1570.8 1796.0 1405.2 1324.0 1636.8 1644.9 1009.2 1388.4 True False 1427.1937963862163 1528.0688394193994 1357.493987786777 1482.36231509543 1278.0999081082093 1310.6817620958157 1513.3348582047593 1601.2719086117866 1712.5386909483248 1566.6146641612436 0.9110050027205174 0.9753954653791771 0.8665142864046734 0.9462201197312794 0.8158355320850368 0.8366331504994223 0.9659904843383998 1.0221223797040724 1.0931460876278776 1.0 10.613434652432153 -7.610997859867622 3.0005673132196056 1.0453985610922947 0.8937929466538915 0.6328431067463116 0.0499663745615874 0.1726214134528324 3.1174323759288884 0.028395412437845036 0.014890684102629417 2.4490753104587223e-08 7.610997859867622 -0.15160561443840315 NSPAS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 NSPASPLK 8 0 O43572;E7EMD6 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 NS(0.013)PAS(0.987)PLK 98.898 0.019087 13004000.0 5076.5 6869.2 4258.1 4473.8 3248.4 4474.1 4993.6 4870.6 2497.6 4683.3 True False 5194.772572850527 6064.950870595559 3679.8734080690556 3692.5348136269154 2954.5827935516013 4429.094616157772 4616.928731629574 4741.415866061506 4238.244782513413 5284.447174205093 0.983030466877918 1.147698268269258 0.6963592002644243 0.6987551756882423 0.5591091548750398 0.8381377408364412 0.8736824457563189 0.8972397130215854 0.8020223578355566 1.0 12.367536838436715 -5.260735184087827 24.999953787872414 0.7843871976943965 1.0653643790858867 0.4350876947808966 0.12238793657168423 55.799144385774746 1980851.079301207 0.03328913460655227 0.07802555450122332 5.486113848732205e-06 5.260735184087827 0.2809771813914902 NSPAS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 NSPASPLK 8 0 O43572;E7EMD6 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 NSPAS(1)PLK 89.35600000000002 0.029782 14975000.0 100210.0 70807.0 74351.0 89316.0 74830.0 68612.0 82246.0 104970.0 60062.0 69282.0 True False 94640.72937241392 76237.66921961043 69567.3376072479 77151.00672130613 65429.1864113122 78062.68020227671 86070.60196735717 105275.44532128112 72076.07827249655 67281.64864374597 1.4066351119535334 1.1331123828918979 1.0339719523759678 1.1466872212037797 0.972467050529001 1.1602373273523057 1.2792582182862087 1.5646977659348242 1.0712590985119423 1.0 16.037925436822285 -7.201149808767071 5.027296319186277 1.2758581627662653 1.1277742815957146 0.026516138324855 0.17689042198926075 0.45091768739153515 23.73368239305869 0.06847809967050247 0.051901056653009925 6.292890737625887e-08 7.201149808767071 -0.1480838811705507 NSPAT(ph)LFEVPDTW ddPTM_A459_Selumetinib_30min_R1 2 NSPATLFEVPDTW 13 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 NS(0.001)PAT(0.999)LFEVPDTW;NS(0.013)PAT(0.987)LFEVPDTW 244.58 5.6355e-18 5576300.0 1619.63 1935.78 1053.6399999999999 1332.37 1610.1399999999999 1517.38 1862.8600000000001 1741.73 830.34 2013.37 True False 1657.3642277486242 1709.1379776802933 910.5614752302386 1099.6965911824605 1464.5031212933054 1502.1165348708075 1722.3429704028092 1695.5336624636193 1409.0263343658662 2271.8056513845604 0.7295360968657408 0.7523257883607485 0.40080958275427014 0.4840627940652609 0.6446427846505085 0.6611994005540646 0.7581383422270831 0.7463374613186079 0.6202230958916446 1.0 11.149623704990338 -7.037032378843042 1.8196559927883 0.7647355859267199 0.5907086246646679 0.29227022264576863 0.1308990311928155 0.5364663459937465 3.5548949672731545 0.06424279656247647 0.04777651790358739 9.182641327110983e-08 7.037032378843042 -0.17402696126205197 NSPAT(ph)PPNTLNLR ddPTM_A459_Selumetinib_30min_R2 2 NSPATPPNTLNLR 13 0 Q92870-2;H0YAJ5;G5E9Y1;Q92870;Q92870-4;D6RDY3;D6RB00;D6RB55 Q92870-2 APBB2 Amyloid beta A4 precursor protein-binding family B member 2 1 NS(0.023)PAT(0.529)PPNT(0.448)LNLR;NSPAT(0.681)PPNT(0.319)LNLR 115.12 0.0095105 10755200.0 70979.0 66499.0 77987.0 80059.0 93999.0 58621.0 53525.0 60282.0 58283.0 70054.0 True False 67034.27133144967 71599.25947201355 72969.4013258253 69154.82609052172 82190.0052582779 66695.51064154465 56014.01855777543 60457.41063977769 69941.22856308347 68031.35899784908 0.985343705004762 1.052444939021096 1.072584796198652 1.0165139592861603 1.2081194094752168 0.9803642264981556 0.8233558668076351 0.888669747751021 1.0280733707714815 1.0 16.053912288295848 -6.993087852683365 24.99998858829932 0.9223347597086728 1.0667523996104575 0.4026271157342577 0.07584017793315732 158.45224889987188 573089.578135942 0.026622791958633325 0.023426888111666433 1.0160431384628065e-07 6.993087852683365 0.1444176399017847 NSPEDLGLS(ph)LTGDSCK ddPTM_A459_Selumetinib_30min_R2 1 NSPEDLGLSLTGDSCK 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 NS(0.012)PEDLGLS(0.792)LT(0.192)GDS(0.004)CK 98.407 0.011809 0.0 8401.7 9100.4 7428.8 8581.5 6469.6 6891.2 6928.1 8397.0 6506.5 7414.9 True False 7934.767148669896 9798.371417601971 6950.839095865877 7412.684896086799 5656.83100904217 7840.400247914796 7250.270377769712 8421.43387980182 7807.981806799621 7200.812570776131 1.1019266326792696 1.3607313509822219 0.9652853796077474 1.029423391211505 0.785582314973719 1.088821597681125 1.006868364716824 1.1695116067844167 1.0843195445035791 1.0 12.813944000339728 -5.274675710793411 24.968968227375363 1.0167729911597598 1.2313290001042891 0.37531943705238935 0.1110009713820151 707.9887118380342 1335547.780628154 0.029621225056755737 0.06222747054376444 5.312810055382584e-06 5.274675710793411 0.2145560089445293 NSPFQIPPPS(ph)PDSK ddPTM_A459_Selumetinib_30min_R1 1 NSPFQIPPPSPDSK 14 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 NSPFQIPPPS(0.642)PDS(0.358)K 113.11 0.0034008000000000003 21970000.0 1838.2 2103.2 2959.2 2572.1 2412.4 2712.0 2162.4 1926.2 1409.0 2149.7 True False 1881.026483485439 1856.9563662488454 2557.356893722069 2122.931019296748 2194.198845943812 2684.719742298982 1999.288427041772 1875.1109188206115 2390.9700907116417 2425.6349348512144 0.7754779816447601 0.7655547582896058 1.0543041151734294 0.8752063176509973 0.9045874193259018 1.1068111296243595 0.8242330279450752 0.7730392120756739 0.9857089607172487 1.0 11.244146721636985 -5.2271934783202045 24.233236058868336 0.930555276383814 0.7705162146143701 0.32550527689253994 0.09702948528301458 541.1726463191261 382944.25511001295 0.02513917123607677 0.06650307210373017 5.926612350028009e-06 5.2271934783202045 -0.16003906176944382 NSPFQIPPPS(ph)PDSK ddPTM_A459_Selumetinib_30min_R2 2 NSPFQIPPPSPDSK 14 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 NSPFQIPPPS(0.522)PDS(0.478)K;NSPFQIPPPS(0.961)PDS(0.039)K 114.29 0.0030235 17983800.0 264293.0 262394.0 238483.0 244956.0 217430.0 163024.0 220170.0 190827.0 142792.0 215737.0 True False 249604.65310870603 282518.7760703108 223139.26342065822 211592.5702273304 190114.49955113753 185479.07621547196 230408.34125857858 191382.27497688943 171354.3899418327 209508.11225795798 1.1913841923284525 1.348486094526297 1.0650626413258728 1.0099492947881938 0.9074326406848535 0.8853073717121743 1.099758566746509 0.9134838403834644 0.8178890454172566 1.0 17.67664658131008 -5.526436526517721 2.3687975282435483 0.9433878968086225 1.2710979054237952 0.702886753614504 0.08249050697618597 0.15793739078010574 1.7533866097523807 0.02366602993381056 0.055755980257071625 2.975524109157853e-06 5.526436526517721 0.32771000861517274 NSPFQIPPPSPDS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 NSPFQIPPPSPDSK 14 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 NSPFQIPPPS(0.147)PDS(0.853)K 102.72 0.0073923 24640000.0 2498.7 3263.6 3227.6 3634.0 2709.2 3008.9 2554.8 2921.0 1947.7 2762.1 True False 2556.9148483761646 2881.4961947935217 2789.3096479377373 2999.390118628506 2464.1533383481096 2978.633197862612 2362.0893791187186 2843.5255912548064 3305.1046456203458 3116.642440132364 0.8204068633126784 0.9245514203647771 0.8949726192585875 0.9623786418377599 0.7906435806102471 0.9557186154906206 0.75789553164732 0.9123682443129543 1.0604696268847504 1.0 11.605776934512305 -8.14848873011487 4.98039424122084 1.0281507818186708 0.8762211724756246 0.4712334122063163 0.0655997446942765 0.184835238466918 6.65744239641707 0.044852091687248956 0.016032144832564564 7.104136049041009e-09 8.14848873011487 -0.15192960934304622 NSPFQIPPPSPDS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 NSPFQIPPPSPDSK 14 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 NSPFQIPPPS(0.116)PDS(0.884)K;NSPFQIPPPS(0.05)PDS(0.95)K 130.29 0.00098291 21663000.0 215310.0 192963.0 176847.0 180524.0 157348.0 130606.0 173295.0 138904.0 108707.0 166789.0 True False 203343.93215422067 207762.64162616205 165468.85655645473 155936.3197787305 137580.5375310323 148595.79097677598 181353.56087752804 139308.187643205 130451.4375273597 161973.36820013518 1.2554158403557294 1.2826963094911343 1.0215806363426394 0.9627281417402812 0.8494022138320729 0.9174087853329703 1.1196504887979275 0.8600684741646851 0.8053881880518357 1.0 17.305397097891927 -5.383682367471064 2.5800503149651073 0.9291279647132077 1.2791028046796689 0.7152412864930654 0.08398980242244614 0.1560400679459062 1.981493883028827 0.024421394708326372 0.06555554303660038 4.133497054881959e-06 5.383682367471064 0.34997483996646117 NSPLDCGSAS(ph)PNK ddPTM_A459_Selumetinib_30min_R1 2 NSPLDCGSASPNK 13 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 NSPLDCGS(0.035)AS(0.965)PNK;NSPLDCGS(0.238)AS(0.762)PNK 165.89 0.00034641 33634000.0 7523.4 11011.1 6239.7 6556.3 6101.3 6768.1 7379.0 7437.2 5312.7 8510.9 True False 7698.680582011944 9721.915293078482 5392.383012218706 5411.365281993416 5549.438492272008 6700.0190589431195 6822.396089133014 7239.941296569751 9015.263875744313 9603.356918186351 0.801665568363139 1.012345513751302 0.5615102154546484 0.5634868440373851 0.5778644425641165 0.6976746898009135 0.7104178411002413 0.7538969298182718 0.9387617218174681 1.0 13.229323082440485 -8.269219235699298 2.2149997229154246 1.0011629167470568 0.6992919184699566 0.4101483206994324 0.12678301109899096 0.3358008025614515 3.022612331129918 0.13108648041244658 0.03788628384860742 5.379981277373793e-09 8.269219235699298 -0.3018709982771002 NSPLDCGSAS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 4 NSPLDCGSASPNK 13 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 NSPLDCGS(0.031)AS(0.969)PNK;NSPLDCGS(0.44)AS(0.56)PNK;NSPLDCGS(0.008)AS(0.992)PNK;NSPLDCGS(0.001)AS(0.999)PNK 216.0 2.147e-08 86796000.0 318370.0 261527.0 296662.0 276295.0 300020.0 264272.0 399332.0 337286.0 247979.0 287295.0 True False 300676.2699360887 281585.2799581546 277575.0899011633 238663.14436454015 262328.8053871693 300673.06917763787 417901.72926134657 338267.4464192968 297581.7291121749 279000.04686794477 1.077692542748581 1.0092660668671265 0.9948926282171704 0.855423312805045 0.940246456343191 1.0776810704979964 1.4978554088169964 1.2124279196963872 1.066601000440065 1.0 18.089905838843052 -7.006457071329362 23.5749664540275 1.2227583840851917 0.9755035546283388 0.36747267205817014 0.13319620032909277 135.42398318503308 494439.6282013672 0.048593587452352247 0.04130076980486453 9.852420261277883e-08 7.006457071329362 -0.24725482945685284 NSPLDELEEGEIRS(ph)DSETSKPQESFEK ddPTM_A459_Selumetinib_30min_R1 1 NSPLDELEEGEIRSDSETSKPQESFEK 27 2 A0A087WTW5;Q9UKL3 A0A087WTW5 CASP8AP2 CASP8-associated protein 2 1 NS(0.002)PLDELEEGEIRS(0.28)DS(0.28)ET(0.216)S(0.216)KPQES(0.008)FEK 46.399 0.019797 6943000.0 441.12 416.29 444.59 717.82 734.37 616.77 513.05 494.9 360.54 510.85 True False 451.3972377298972 367.55057327202957 384.2171199580614 592.466212150224 667.9463631635542 610.565853782354 474.35022544107534 481.7736443382416 611.8100472002669 576.4225736003824 0.7831012496794378 0.6376408386928338 0.6665546034365204 1.0278331198058948 1.158778982216999 1.0592330726548578 0.8229209735459269 0.8357994055108635 1.0613915471402369 1.0 9.17098302456503 -5.759840450797964 24.99927487325366 0.9906085066641666 0.689953029503241 0.644850453703915 0.10174497470791041 29.022526270926328 453750.47823129426 0.031490047467284864 0.051058603571640875 1.7384393716815766e-06 5.759840450797964 -0.30065547716092555 NSPLEPDTST(ph)PLKK ddPTM_A459_Selumetinib_30min_R2 2 NSPLEPDTSTPLKK 14 1 A0A3F2YNX6;Q92794;A0A3B3ITI3;A0A3B3IS53 A0A3F2YNX6 KAT6A Histone acetyltransferase KAT6A 1 NSPLEPDT(0.036)S(0.137)T(0.826)PLKK;NSPLEPDT(0.082)S(0.082)T(0.835)PLKK 97.214 0.014044 11614100.0 156125.0 128111.0 137328.0 162766.0 146566.0 118615.0 134668.0 137738.0 98093.0 131480.0 True False 147448.19751789374 137936.7017582093 128492.46599142134 140596.99001298862 128153.06876333548 134953.13957023647 140930.32883957966 138138.79477624665 117714.3409474213 127683.83077393446 1.1547914612536359 1.0802988986321036 1.0063331058645835 1.101133864489992 1.0036749993053686 1.0569321013650694 1.1037445225864053 1.081881659869861 0.9219204987343758 1.0 16.962216315536807 -4.854926868668597 3.1451559714206545 1.0418361740820592 1.1629631886307354 0.3203581152018008 0.05305255831181151 0.3751530316943676 6.0480160370397655 0.01326506943761495 0.10296446642364265 1.3966035168776575e-05 4.854926868668597 0.12112701454867625 NSPNNISGISNPPGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 NSPNNISGISNPPGTPR 17 0 Q9NW25;A0A087WVT6;Q9BWW4-2;Q9BWW4-3;Q9BWW4 Q9NW25 SSBP3 Single-stranded DNA-binding protein 3 1 NSPNNISGISNPPGT(1)PR;NSPNNISGISNPPGT(1)PR 294.28 8.800299999999997e-76 15508800.0 34645.0 32373.0 29154.0 35775.0 34341.0 25389.2 27998.0 25719.0 23185.6 30626.0 True False 32719.56959492349 34855.90500439853 27278.263380475146 30902.383284682757 30026.77656756477 28886.331839789626 29299.9624769845 25793.838031990337 27823.367859791506 29741.74780409578 1.1001226225991207 1.17195214060683 0.9171708253379318 1.0390237819321144 1.0095834570767808 0.9712385442193698 0.9851459527522979 0.8672603305592629 0.9354987488650519 1.0 14.86020181087419 -4.516288410020593 0.498599780094177 0.9408941112454295 1.3334460206443035 0.48358532781473174 0.06050705175756782 4.743972896095645 0.7465304134835301 0.037481758649891624 1.1543018658406112 3.0458715892013922e-05 4.516288410020593 0.39255190939887397 NSPQS(ph)SPTSTPK ddPTM_A459_Selumetinib_30min_R1 1 NSPQSSPTSTPK 12 0 Q9Y6Y0 Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein 1 NSPQS(0.493)S(0.493)PT(0.014)STPK 182.72 0.00010424 12874000.0 5564.6 5918.5 6243.5 6383.6 4923.7 5607.1 5171.8 5161.6 2982.2 3683.6 True False 5694.244353173254 5225.559268563998 5395.666993090614 5268.82409501291 4478.352204349841 5550.697664839465 4781.686962159931 5024.697600760291 5060.575588729781 4156.425941302477 1.3699857602632706 1.2572241975100586 1.2981506393446773 1.2676333391764576 1.0774526642826416 1.3354496731632062 1.1504323737960116 1.208898623894578 1.217530556347162 1.0 12.021127790664858 -14.522878738258417 0.06683546201654617 0.1947079667611919 1.5452419987281543 0.5630379136815551 0.07218430937415174 257.5224576261028 1.240500454220271 32.785894268080504 4.454684854152582 3.0000000485057123e-15 14.522878738258417 1.3505340319669623 NSPQS(ph)SPTSTPK ddPTM_A459_Selumetinib_30min_R2 1 NSPQSSPTSTPK 12 0 Q9Y6Y0 Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein 1 NSPQS(0.608)S(0.351)PT(0.026)S(0.007)T(0.007)PK 121.56 0.0037573 9928300.0 32899.0 35792.0 35003.0 34898.0 34938.0 26012.0 34710.0 37099.0 23853.0 37739.0 True False 31070.605285131714 38537.1313105808 32750.94508838483 30144.83219759216 30548.77609031706 29594.916886574123 36324.083776560205 37206.951947929905 28624.266508505556 36649.37701230229 0.8477799029080925 1.051508496246603 0.8936289715754553 0.8225196348487257 0.8335414836673101 0.8075148692606655 0.9911241810295195 1.0152137629908538 0.7810300976984437 1.0 15.161501054336886 -9.582092005642629 10.353860329657001 0.9999999999991631 0.8984304588399118 0.1103968729040391 0.08959542757146195 0.0 0.0 0.08944963068493428 0.02169472208743969 2.6176284027475587e-10 9.582092005642629 -0.10156954115925132 NSPQSS(ph)PTSTPK ddPTM_A459_Selumetinib_30min_R1 1 NSPQSSPTSTPK 12 0 Q9Y6Y0 Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein 1 NSPQS(0.106)S(0.816)PT(0.07)S(0.007)T(0.001)PK 168.0 0.00040644 12338000.0 4905.7 6143.9 5870.9 6158.6 4745.3 5545.6 5603.1 4784.3 2277.9 3631.0 True False 5019.99326516947 5424.569331778379 5073.664026545319 5083.116121239824 4316.0884528507595 5489.816299001928 5180.453655918311 4657.404822403413 3865.4299287665394 4097.074218935088 1.2252629552008134 1.3240105113810543 1.23836273287333 1.2406697681354253 1.053456252489514 1.3399357701723165 1.2644275839515584 1.1367635960507365 0.943461046153868 1.0 12.000378312291076 -8.066890119461831 3.2852334036560276 0.9739903390784002 1.239833710421524 0.6734394578545959 0.07422368289911273 0.15353030107699545 3.1136772732411853 0.05850126418589624 0.0202260831022073 8.57254711199802e-09 8.066890119461831 0.26584337134312386 NSPQSS(ph)PTSTPK ddPTM_A459_Selumetinib_30min_R2 1 NSPQSSPTSTPK 12 0 Q9Y6Y0 Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein 1 NSPQS(0.009)S(0.986)PT(0.003)S(0.003)TPK 183.28 0.0001043 10831000.0 64780.0 67772.0 66315.0 69690.0 72477.0 57260.0 60873.0 62355.0 51483.0 80727.0 True False 61179.786934886535 72969.89447867355 62048.36509831276 60198.10177804454 63371.79130739908 65147.04524547262 63703.71511756114 62536.442726574074 61781.03855520862 78396.20175606475 0.7803922328437761 0.9307835436431534 0.7914715727093588 0.7678701318382124 0.8083528268956808 0.8309974690889004 0.8125867540850984 0.7976973542820426 0.7880616301723983 1.0 16.258496137966063 -10.689571627543623 5.340894759056885 1.0000066024208256 0.8136588293904712 0.6301164408574785 0.043189884286876916 3.4367534761774547e-06 5.36152254736157e-07 0.04232634836885666 0.01026528366567658 2.0437528350858968e-11 10.689571627543623 -0.18634777303035444 NSPS(ph)AASTSSNDSK ddPTM_A459_Selumetinib_30min_R2 2 NSPSAASTSSNDSK 14 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 NS(0.352)PS(0.642)AAS(0.001)TS(0.004)S(0.001)NDSK;NS(0.354)PS(0.646)AASTSSNDSK 190.18 0.00010071 6662300.0 12486.0 7404.700000000001 10685.0 11202.1 10116.0 9689.9 20351.0 36051.0 13402.7 15354.9 True False 11792.078105418232 7972.616680136839 9997.538732948371 9676.354655299638 8845.137641812567 11024.595768845717 21297.361824741467 36155.90244143565 16083.614502727023 14911.564140178618 0.7908008841034285 0.5346599863829804 0.6704554021942205 0.6489161408109485 0.5931730272332528 0.739331948359487 1.4282446579401131 2.424688791970187 1.0786000953039099 1.0 13.864143975797472 -7.287434295562911 4.022369103458517 1.6220011497276747 0.6468597536287528 0.5328792460620033 0.3708436802887456 0.14668499443977687 5.4596790871253935 0.15073734924562932 0.10316693807841544 5.159002097408018e-08 7.287434295562911 -0.9751413960989219 NSPSAASTS(ph)SNDSK ddPTM_A459_Selumetinib_30min_R2 1 NSPSAASTSSNDSK 14 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 NS(0.038)PS(0.087)AAS(0.008)T(0.002)S(0.495)S(0.369)NDSK 158.65 3.6654e-05 0.0 20449.0 10852.0 16747.0 17111.0 19235.0 13715.0 26847.0 44484.0 23138.0 37133.0 True False 19312.526443832874 11684.31350532027 15669.51625275493 14780.452281878599 16818.52733691821 15604.116757625872 28095.438696321282 44613.44107527734 27766.246529736378 36060.87380687939 0.5355534795762101 0.3240163720905519 0.43452957731062053 0.4098750452092181 0.46639267331646617 0.43271599133155364 0.7791114227232472 1.2371702725286253 0.7699826321024802 1.0 15.138146735320756 -7.412142763799298 3.365705098681218 1.0055266043818694 0.4286296927036532 0.8260522632482012 0.11807476087222406 0.08961704077385213 1.8907089911274233 0.05094670509413259 0.031895330196242286 3.8713036426536506e-08 7.412142763799298 -0.5768969116782161 NSPSLQPPHPGS(ph)STPTLASR ddPTM_A459_Selumetinib_30min_R2 1 NSPSLQPPHPGSSTPTLASR 20 0 Q8TER5;Q8TER5-2;Q8TER5-4 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 NSPSLQPPHPGS(0.582)S(0.117)T(0.117)PT(0.166)LAS(0.018)R 85.387 0.0016031 9728500.0 12775.0 10065.0 13944.0 17224.0 12391.0 9153.9 12123.0 12099.0 9439.2 12097.0 True False 12065.016642376899 10836.95313592412 13046.858221079287 14878.061486942719 10834.331803054518 10414.766634169266 12686.743521268781 12134.206086902723 11327.303753284095 11747.728178219377 1.027008495544337 0.9224722407193707 1.110585640317124 1.2664628650948078 0.9222491054178185 0.8865345261800098 1.0799316539167434 1.0328980976423925 0.9642122784459075 1.0 13.520094169283672 NSPSLQPPHPGSS(ph)TPTLASR ddPTM_A459_Selumetinib_30min_R2 1 NSPSLQPPHPGSSTPTLASR 20 0 Q8TER5;Q8TER5-2;Q8TER5-4 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 NSPSLQPPHPGS(0.1)S(0.297)T(0.297)PT(0.297)LAS(0.011)R 138.25 5.7357e-05 9505300.0 20219.0 12059.0 19105.0 24827.0 18460.0 16612.0 15488.0 18794.0 11268.0 19788.0 True False 19095.308923069937 12983.886524203572 17875.80509995122 21445.51977103618 16140.889765506134 18900.152211278226 16208.22268888978 18848.687428485806 13521.914854225486 19216.66902460156 0.9936846442338026 0.6756574985800787 0.9302239153448634 1.1159852804656831 0.8399421223752278 0.9835290490293545 0.8434460034743635 0.9808509166888051 0.7036555001761472 1.0 14.230070663727757 -5.1279582086549365 0.0049007851460817755 1.792662040208752 8.142513825409729e-08 0.005338799361905733 0.1319684029126455 257656.20572347732 221.22322357786976 39189.307326722344 41757.114237613256 7.448036415179833e-06 5.1279582086549365 -1.792661958783614 NSPT(ph)FKSFEEKVENLK ddPTM_A459_Selumetinib_30min_R1 1 NSPTFKSFEEKVENLK 16 2 H0YC42;P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;E5RK35 H0YC42 TPD52 Tumor protein D52 1 NS(0.005)PT(0.961)FKS(0.035)FEEKVENLK 118.51 0.0057087 37024000.0 3258.0 1891.4 7467.9 11900.0 3408.8 4843.4 2359.2 2228.3 1161.1 1872.1 True False 3333.9050610355575 1669.9540087119944 6453.800198238391 9821.888390665716 3100.47464187252 4794.679793455345 2181.243644597184 2169.198245461513 1970.3018966112759 2112.40227079823 1.5782529242291283 0.7905473459280821 3.0551946887463077 4.64962972557033 1.4677482053174082 2.269775913298721 1.0325891402175686 1.026886912331249 0.9327304386331409 1.0 11.044668882058714 -7.198733090824013 2.028410853472469 0.9500555741004164 2.394476227721823 0.2936304374853661 0.9826554115000445 0.48278572998046804 3.887865068186443 0.5280790041398616 0.35420293578216616 6.328006391996322e-08 7.198733090824013 1.4444206536214064 NSPTPAT(ph)S(ph)TESLSPLHNVALR ddPTM_A459_Selumetinib_30min_R2 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 2 NS(0.014)PT(0.036)PAT(0.827)S(0.558)T(0.558)ES(0.006)LSPLHNVALR 83.39299999999999 0.0044402 2409300.0 6267.5 7293.8 10303.0 12877.0 12526.0 7536.7 7455.6 10474.0 9068.0 9438.6 True False 5919.177440790383 7853.211006736545 9640.116197058223 11123.130385935992 10952.371896139208 8574.812013649203 7802.300172991134 10504.477605935957 10881.853381089526 9166.083093572075 0.6457695594033335 0.8567684720471046 1.051715994568997 1.213509660820808 1.1948802759403097 0.9354935937317093 0.8512142093128825 1.1460159698205727 1.1871868572433817 1.0 13.162089648940862 -4.990009724875605 2.2842341873382535 1.0751532441745797 0.6246891087841916 0.595129380634585 0.11278937107388375 0.3033096278915852 2.575988646897834 0.033674883141173964 0.23195719181448984 1.023270078598783e-05 4.990009724875605 -0.4504641353903881 NSPTPAT(ph)STESLSPLHNVALR ddPTM_A459_Selumetinib_30min_R2 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 NSPTPAT(0.89)S(0.092)T(0.018)ESLSPLHNVALR 153.34 1.1107e-06 3194100.0 11566.0 11072.0 16163.0 12784.0 16902.0 10677.0 11200.0 10814.0 11180.0 14395.0 True False 10923.208022366436 11921.18679790878 15123.09017694381 11042.797146369934 14778.61965420284 12147.659833844067 11720.822192378973 10845.466949645923 13416.31239530005 13979.378947298332 0.7813800644182026 0.8527694143531805 1.0818141659910088 0.7899347451700689 1.057172833637146 0.8689699220287419 0.8384365454692929 0.7758189394917239 0.9597216332627495 1.0 13.77101264801993 -12.75102887808876 1.101820560675082 3.465890039543463 0.8906683343179614 0.09148860777920298 0.10437517114039467 272208.4233311192 4087.3699020861163 1674489.5687248341 0.030535536793337807 1.774071511401589e-13 12.75102887808876 -2.5752217052255015 NSPTPATS(ph)TESLSPLHNVALR ddPTM_A459_Selumetinib_30min_R2 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 NSPTPAT(0.018)S(0.724)T(0.241)ES(0.017)LSPLHNVALR 105.71 9.5733e-05 3316900.0 9204.4 9702.1 11503.0 14178.0 15538.0 8350.6 7610.4 10243.0 11343.0 13739.0 True False 8692.856296132593 10446.219872831529 10762.909503519433 12246.93194158581 13585.977528517562 9500.819350800624 7964.29867972151 10272.805434180065 13611.916949900584 13342.319371791013 0.6515251249727583 0.782938826581939 0.806674552122842 0.9179012734081958 1.0182620539905305 0.7120815419010074 0.5969201049526682 0.7699415032666161 1.0202062003312233 1.0 13.703721859814387 -8.262502146384646 24.663610214729225 1.0101031370227984 0.7867837728874857 0.38690667661241684 0.11471519924230653 93.6261497520191 2172594.587444832 0.10232445081812741 0.03224647410093091 5.46383849518731e-09 8.262502146384646 -0.22331936413531273 NSPTPATST(ph)ESLSPLHNVALR ddPTM_A459_Selumetinib_30min_R2 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 NS(0.002)PT(0.006)PAT(0.02)S(0.39)T(0.553)ES(0.029)LSPLHNVALR 82.51700000000002 0.002102 3162500.0 5790.7 6319.1 10429.0 13023.0 15456.0 7685.1 7950.1 7087.1 7548.5 10997.0 True False 5468.876076008761 6803.754650891015 9758.009494236645 11249.24493407194 13514.279101606866 8743.652766608135 8319.795402824288 7107.722287667431 9058.410922712199 10679.488036362613 0.5120915962813735 0.6370862187143144 0.913715101417931 1.0533505815793192 1.2654425994572087 0.8187333266198578 0.7790444049842274 0.6655489723352217 0.8482064769274703 1.0 13.382554866920934 -5.151514192415615 3.2588369565067166 0.9156347469034612 0.5331514785363768 0.44346004917764503 0.15649473323344343 0.2695237059298656 5.261953914354698 0.04712693023016008 0.15986993656867024 7.054817890619798e-06 5.151514192415615 -0.38248326836708446 NSPTPATSTES(ph)LSPLHNVALR ddPTM_A459_Selumetinib_30min_R2 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 NSPTPATSTES(0.821)LS(0.179)PLHNVALR 227.24 6.3154e-25 7247800.0 18952.0 20222.0 17991.0 25102.0 21246.0 10984.0 18907.0 14488.0 13417.0 19813.0 True False 17898.72371086707 21772.9623760216 16833.47864711972 21683.06429663471 18576.887538350114 12496.946297175537 19786.212963509744 14530.157681382485 16100.7749023024 19240.947209643742 0.930241298198462 1.1315951412781171 0.87487785625661 1.1269229139492134 0.9654871631807818 0.6494974577401237 1.0283388207412527 0.7551685227897634 0.8367974157858789 1.0 14.231892202618875 -6.537286438110192 24.998009255273363 0.8448832338625383 1.018112196896399 0.2740681133598122 0.12528463466432785 278.80396161189856 483734.37177665345 0.03831218273323175 0.03832781473880626 2.902107943266229e-07 6.537286438110192 0.17322896303386082 NSPTPATSTESLS(ph)PLHNVALR ddPTM_A459_Selumetinib_30min_R1 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 NSPTPATSTES(0.066)LS(0.934)PLHNVALR 139.67 1.4608e-05 6819400.0 4927.7 5779.5 5847.3 5853.4 4962.6 4936.1 5209.1 4672.4 3384.3 4687.4 True False 5042.505822364924 5102.833453183345 5053.268776919796 4831.213571926277 4513.733706218194 4886.447315620207 4816.173393129529 4548.472773905834 5742.9099205077455 5289.073449142476 0.9533816973523919 0.9647877841459497 0.9554166387572267 0.9134328759812491 0.8534072649246365 0.9238758664643714 0.9105892439270967 0.8599753468432706 1.0858064225670472 1.0 12.368799294826333 -8.26552043820691 24.999901225789124 1.0429032173176633 0.9175369939549047 0.6112409268394443 0.04020570540121836 256.2390878008791 1569644.941674492 0.03605864295575778 0.010627181934187244 5.425997155999902e-09 8.26552043820691 -0.1253662233627586 NSPTPATSTESLS(ph)PLHNVALR ddPTM_A459_Selumetinib_30min_R2 1 NSPTPATSTESLSPLHNVALR 21 0 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 NSPTPATSTES(0.026)LS(0.974)PLHNVALR 186.27 8.5688e-17 5637000.0 19581.0 17490.0 18227.0 21375.0 24455.0 14085.0 16187.0 14346.0 17574.0 20931.0 True False 18492.766408953576 18831.426760786166 17054.294664057084 18463.688126068308 21382.744269526116 16025.08089910029 16939.727573932007 14387.744484891851 21089.291058587034 20326.667644730893 0.9097785594849973 0.9264394484094236 0.8390108483166901 0.9083480110353697 1.0519552266634802 0.7883771791415272 0.8333745535669811 0.7078260311213118 1.0375183688337537 1.0 14.311086098594537 NSQDDYDEER ddPTM_A459_Selumetinib_30min_R2 1 NSQDDYDEER 10 0 O76094-2;O76094;R4GNC1;D6RDY6 O76094-2 SRP72 Signal recognition particle subunit SRP72 0 173.64 0.001493 3560900.0 13336.0 15451.0 17326.0 17433.0 15037.0 12491.0 10183.0 13470.0 10005.0 14270.0 False True 12594.838508237835 16636.042017204512 16211.264023122458 15058.595326397619 13147.917627514387 14211.521867991592 10656.5296772317 13509.19546992146 12006.27956305697 13857.988022087338 0.9088504397726241 1.2004658966864032 1.1698136841570643 1.0866364801583543 0.9487609317138089 1.025511195805681 0.7689810137118719 0.9748309385453385 0.8663797041764612 1.0 13.75843019393226 -6.441107813295757 1.7550229483785653 0.9109112366195625 1.1076612345639305 0.381860402167149 0.09936371134331595 0.3426728709717066 2.1107782180728485 0.03639382173888639 0.04221199457137134 3.6215308301157e-07 6.441107813295757 0.19674999794436798 NSQDIT(ph)PVDNSMDSNIHQR ddPTM_A459_Selumetinib_30min_R2 1 NSQDITPVDNSMDSNIHQR 19 0 Q59FP8;Q92859-3;Q92859-2;Q92859-4;Q92859 Q59FP8 NEO1 Neogenin 1 NSQDIT(1)PVDNSMDSNIHQR 198.37 6.0198e-15 4121100.0 11338.0 4937.9 11598.0 12820.0 13618.0 9767.5 17318.0 12700.0 8096.2 11264.0 True False 10707.879349610112 5316.621052148997 10851.79730694761 11073.89388426647 11907.185093535341 11112.88446446304 18123.32131496599 12736.95489740182 9715.666226728821 10938.779052613289 0.9788916384641653 0.48603422983288513 0.9920483131392166 1.0123519115801962 1.0885296280566796 1.0159163477946067 1.65679562845145 1.1643854251136871 0.8881856174257159 1.0 13.41716409820643 -5.780121933660276 1.4096465639307554 1.1705459699007998 0.7343869370443107 0.29154986635669955 0.22831532148196343 0.5031244716552999 2.0106565490614643 0.07818033168224904 0.18143249427018712 1.6591210228597793e-06 5.780121933660276 -0.43615903285648916 NSQEDS(ph)EDS(ph)EDKDVK ddPTM_A459_Selumetinib_30min_R2 1 NSQEDSEDSEDKDVK 15 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 2 NS(0.143)QEDS(0.857)EDS(1)EDKDVK 116.04 0.022255 0.0 98195.0 90454.0 75324.0 49438.0 50754.0 44887.0 69020.0 58936.0 28100.0 63722.0 True False 92737.71500572993 97391.53094454859 70477.73584657027 42704.45911469313 44377.82877348307 51069.7768063837 72229.56676053547 59107.49400261999 33720.785179600294 61882.18029036083 1.498617446421411 1.573821906202599 1.1389019507049971 0.6900929946927719 0.7171342148136245 0.8252743611611024 1.1672110843803998 0.9551617885032236 0.5449191515453579 1.0 15.917236407601397 -5.45587510616217 3.3970804210763395 0.8495925255596524 1.5321749065099737 0.7304432395321198 0.16740129000413587 0.12794226157167837 2.8594981533768644 0.048379857518116076 0.10773102023203317 3.5004581827266356e-06 5.45587510616217 0.6825823809503213 NSQEDS(ph)EDSEDKDVK ddPTM_A459_Selumetinib_30min_R1 5 NSQEDSEDSEDKDVK 15 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 NS(0.003)QEDS(0.997)EDS(0.001)EDKDVK;NS(0.003)QEDS(0.813)EDS(0.185)EDKDVK;NS(0.002)QEDS(0.99)EDS(0.008)EDKDVK;NS(0.002)QEDS(0.995)EDS(0.002)EDKDVK;NSQEDS(1)EDSEDKDVK 142.4 0.0018114 842875200.0 20454.0 23341.5 28757.999999999996 29335.8 16589.2 23703.4 19924.1 20385.7 16198.0 22387.1 True False 20930.53840344424 20608.666328831037 24852.82155638661 24212.85323116734 15088.709789061135 23464.96531696524 18421.20909601507 19845.00501391409 27486.822944888012 25260.702353820354 0.8285810152970179 0.815839007172904 0.983853148985303 0.9585186069660276 0.5973194877053434 0.9289118326282986 0.7292437414444695 0.7856078083637604 1.0881258390953246 1.0 14.624607132225456 -8.261478244199038 24.99996440451446 1.0440629358011804 0.8299103235117541 0.38190870406424116 0.10968938652792425 3.6957192963395307 2372733.180080044 0.08726652249488585 0.028025159651306086 5.476735357521043e-09 8.261478244199038 -0.21415261228942628 NSQEDS(ph)EDSEDKDVK ddPTM_A459_Selumetinib_30min_R2 6 NSQEDSEDSEDKDVK 15 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 NSQEDS(0.993)EDS(0.007)EDKDVK;NSQEDS(0.614)EDS(0.385)EDKDVK;NSQEDS(0.876)EDS(0.124)EDKDVK;NS(0.03)QEDS(0.957)EDS(0.013)EDKDVK;NSQEDS(0.994)EDS(0.006)EDKDVK;NS(0.001)QEDS(0.983)EDS(0.016)EDKDVK 118.52 0.0011084 1040582000.0 233459.0 217008.0 183309.0 163480.0 143529.0 120029.0 178218.0 155150.0 87415.90000000001 151076.0 True False 220484.28339042398 233651.81580930148 171515.09851174837 141213.74198127023 125497.60385445981 136561.90523522234 186505.49013226732 155601.4608135347 104901.52260432097 146714.04333741145 1.5028164882850137 1.592566127238082 1.1690434985647535 0.9625100554042282 0.8553891706592921 0.9308032287076886 1.2712177095640662 1.0605764606710761 0.7150066906892445 1.0 17.16264744554057 -5.420290933030995 3.03174628811865 0.9809428624890141 1.5518870224867172 0.7336683651924866 0.1370993551693394 0.1373018731651662 2.3874553477927822 0.03989187797644788 0.09509028508657849 3.7993479346994563e-06 5.420290933030995 0.5709441599977031 NSQKHS(ph)PTSEPTPPGDALPPVSSPHTHR ddPTM_A459_Selumetinib_30min_R2 1 NSQKHSPTSEPTPPGDALPPVSSPHTHR 28 1 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3;Q9H6S3-2;A0A087WX39 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 1 NS(0.167)QKHS(0.448)PT(0.167)S(0.167)EPT(0.05)PPGDALPPVSSPHTHR 54.56 0.0038363 13989000.0 16359.0 15954.0 31575.0 54976.0 57287.0 34192.0 24330.0 27438.0 32767.0 51726.0 True False 15449.832270265637 17177.620499804605 29543.498876260634 47488.17396111023 50090.09490772205 38901.63763592736 25461.393208980382 27517.840037394584 39321.31558647558 50232.53597971196 0.3075662410614816 0.34196204043415895 0.5881347278224761 0.945366843121157 0.9971643662974244 0.7744310908698508 0.506870551374587 0.5478090942593175 0.7827857944969526 1.0 15.61633449057352 -5.4106692468929865 3.295522999096152 0.7705361755103276 0.32217492704202827 0.5707977520818445 0.16070893677058648 0.20544580075730864 4.126683788770894 0.04900792299673999 0.11436156334072468 3.88446088925946e-06 5.4106692468929865 -0.44836124846829933 NSS(ph)DSAIDNPKPNKLPK ddPTM_A459_Selumetinib_30min_R2 1 NSSDSAIDNPKPNKLPK 17 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 NS(0.225)S(0.55)DS(0.225)AIDNPKPNKLPK 47.729 0.045725 14072000.0 71524.0 67795.0 62003.0 74380.0 56212.0 40379.0 53451.0 51568.0 33277.0 56953.0 True False 67548.98241325754 72994.65850471696 58013.79448376209 64249.315687343296 49150.146018344 45940.840725933274 55936.57741114716 51718.05434245802 39933.32983706618 55308.61890833494 1.2213102360268482 1.3197700457083148 1.0489105609364526 1.1616510582885122 0.8886525642558963 0.8306271541886223 1.0113537187369108 0.9350812832295143 0.7220091664781794 1.0 15.755216697033175 -5.8737461669747555 1.1524110749468157 0.8921639539448817 1.2683123574555297 0.6685424765528631 0.09980458179819278 0.30473944259059743 0.8094326839127447 0.03703330055076035 0.08622868200727243 1.3373769477284952e-06 5.8737461669747555 0.37614840351064804 NSS(ph)EASSGDFLDLK ddPTM_A459_Selumetinib_30min_R1 2 NSSEASSGDFLDLK 14 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 NS(0.022)S(0.959)EAS(0.005)S(0.014)GDFLDLK;NS(0.222)S(0.777)EASSGDFLDLK 289.59 1.4324e-66 64420000.0 9156.0 11695.5 7254.0 6935.299999999999 8247.0 8408.1 11194.7 11571.5 7112.400000000001 11080.7 True False 9369.316985525342 10326.185422909553 6268.946643369796 5724.180046704531 7501.060306126113 8323.522147943975 10350.27476609532 11264.58623047072 12069.223330856976 12503.015780158092 0.7493645653390413 0.8258955762734378 0.5013947637591905 0.457823948026094 0.5999400814985828 0.6657211583427058 0.8278222588922021 0.9009495331796092 0.9653049746614307 1.0 13.60998850054197 -7.481630075087571 1.6604528930162505 0.9677661506016495 0.6209497965742304 0.6790825526523676 0.10137707262566538 0.260657624256019 1.3966885214181226 0.07379680682510166 0.03724354141839299 3.298905879267229e-08 7.481630075087571 -0.34681635402741906 NSS(ph)EASSGDFLDLK ddPTM_A459_Selumetinib_30min_R2 2 NSSEASSGDFLDLK 14 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 NS(0.342)S(0.648)EAS(0.008)S(0.002)GDFLDLK;NS(0.269)S(0.671)EAS(0.06)SGDFLDLK 193.41 0.00011552 30114700.0 54463.0 39091.5 50851.0 62733.0 55762.0 41005.2 68205.0 70582.0 52117.0 50433.0 True False 51436.164492663214 42089.692351016136 47579.30202238257 54188.65717953892 48756.679041395066 46653.29409185567 71376.66764564347 70787.38193452089 62541.85627064876 48976.86824932941 1.05021342383131 0.859379005957418 0.9714647694533639 1.1064132746029727 0.995504220343093 0.9525577228489788 1.457354669602027 1.4453227506127877 1.276967239968535 1.0 15.579812905480493 -7.252145481256088 24.966919739428462 1.3320213957605929 0.9881526472107813 0.5515345660917247 0.1333544590401343 428.60688845880355 1151402.014484378 0.05001491818288335 0.038190292818820144 5.595701236330967e-08 7.252145481256088 -0.34386874854981153 NSS(ph)LLEPQK ddPTM_A459_Selumetinib_30min_R2 2 NSSLLEPQK 9 0 Q6P0N0;C9J2Q8;G5E9K5;Q6P0N0-2 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 NS(0.002)S(0.998)LLEPQK;NS(0.008)S(0.992)LLEPQK 115.29 0.0082148 11032600.0 160146.0 142006.0 147596.0 158937.0 157179.0 141857.0 155361.0 164200.0 113259.0 158671.0 True False 151245.7264352322 152897.40357874197 138099.83405037408 137289.50641838243 137432.76882191165 161396.51410036683 162585.59434198128 164677.79481522657 135913.9647208667 154089.7559532319 0.9815430331471036 0.9922619620810365 0.8962298187576404 0.89097101600999 0.8919007494802195 1.0474188443088495 1.0551356469882913 1.0687134507838942 0.8820441299298197 1.0 17.233411427615124 -6.764738649365496 24.99948360915997 1.0177365861611685 0.9298990280238675 0.3153808177885101 0.0585273634273801 104.12793755373302 788999.4885447756 0.021079390404197932 0.019357052424833734 1.718942504757073e-07 6.764738649365496 -0.08783755813730099 NSS(ph)PAPPQPAPGK ddPTM_A459_Selumetinib_30min_R1 4 NSSPAPPQPAPGK 13 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 NS(0.217)S(0.783)PAPPQPAPGK;NS(0.184)S(0.816)PAPPQPAPGK;NS(0.293)S(0.707)PAPPQPAPGK;NS(0.281)S(0.719)PAPPQPAPGK 180.95 0.0001118 406358000.0 33875.5 45567.8 26354.699999999997 24409.5 30154.9 30285.4 40431.0 36387.8 19258.3 34427.8 True False 34664.733239751404 40232.70079210453 22775.876496004672 20146.839048063437 27427.394619280018 29980.756372943077 37381.257118815156 35422.67733976777 32679.928529419456 38846.943485170326 0.8923413306116229 1.035672235254833 0.5862977741015655 0.5186209580621038 0.7060373908117205 0.7717661592703714 0.9622702268219715 0.9118523662817962 0.8412483865531118 1.0 15.245513470016176 -7.171086903268432 5.079945062113404 0.9210618148152 0.7422102925069847 0.2737394928834277 0.14105769792695874 0.3592779626068886 15.226540754054962 0.06211250793640463 0.0475685474670808 6.74393066679014e-08 7.171086903268432 -0.17885152230821533 NSS(ph)PAPPQPAPGK ddPTM_A459_Selumetinib_30min_R2 4 NSSPAPPQPAPGK 13 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 NS(0.028)S(0.972)PAPPQPAPGK;NS(0.216)S(0.784)PAPPQPAPGK;NS(0.052)S(0.948)PAPPQPAPGK;NS(0.409)S(0.591)PAPPQPAPGK 207.31 1.1175e-05 70015000.0 289176.0 236054.0 261239.0 274255.0 267873.0 218701.0 261524.0 257850.0 196957.0 236596.0 True False 273104.755583247 254158.5827667595 244431.16715551674 236900.99588373586 234220.3989249956 248825.07757998793 273685.3841999746 258600.30081063477 236353.90343838243 229764.85872976674 1.1886271777724442 1.1061682111522675 1.0638318170447443 1.0310584359741546 1.0193917391017098 1.0829553263958371 1.1911542335630363 1.125499792441203 1.0286773388456467 1.0 17.809798637028763 -10.392771934079645 0.008942929876912826 1.201588646809103e-07 2.0963129605811823 0.18087873059160464 0.05875414286680923 16112.477659454962 28.837300925519344 3552.5063357508484 3211.4748897227687 4.047884069573924e-11 10.392771934079645 2.0963128404223177 NSS(ph)PGEASLLEK ddPTM_A459_Selumetinib_30min_R1 4 NSSPGEASLLEK 12 0 Q76FK4-2;Q76FK4-4;Q76FK4 Q76FK4-2 NOL8 Nucleolar protein 8 1 NS(0.089)S(0.911)PGEASLLEK;NS(0.011)S(0.989)PGEASLLEK;NS(0.003)S(0.997)PGEASLLEK;NS(0.112)S(0.888)PGEASLLEK 207.08 9.6399e-06 127408000.0 22188.5 29415.0 23457.100000000002 23142.4 21656.4 22989.5 24280.399999999998 24553.6 12219.400000000001 20033.0 True False 22705.448878694755 25971.0781253375 20271.75466062719 19101.01427665062 19697.58244374796 22758.24650279589 22448.909879737817 23902.358766666883 20735.429330334893 22604.43068794453 1.004468955318751 1.148937501849515 0.89680447786896 0.845011959838371 0.8714036073579655 1.0068046754627356 0.9931198971408002 1.0574191890360047 0.9173170347260098 1.0 14.464317962146746 -10.078719555411888 15.348532196839024 0.9999999999882225 0.9718635954146682 0.009621938718761491 0.08729461147797453 0.0 0.0 0.0917533689736836 0.02225346069322164 8.342197060394643e-11 10.078719555411888 -0.028136404573554374 NSS(ph)PGEASLLEK ddPTM_A459_Selumetinib_30min_R2 4 NSSPGEASLLEK 12 0 Q76FK4-2;Q76FK4-4;Q76FK4 Q76FK4-2 NOL8 Nucleolar protein 8 1 NS(0.007)S(0.993)PGEASLLEK;NS(0.227)S(0.773)PGEASLLEK;NS(0.028)S(0.972)PGEASLLEK;NS(0.059)S(0.941)PGEASLLEK 178.68 0.00010379 88508200.0 273058.0 207885.0 255331.0 266758.0 264876.0 194028.0 227282.0 235807.0 175623.0 216354.0 True False 257882.5294977806 223829.11104437022 238903.2814433733 230425.10021678303 231599.90885851558 220753.5957891821 237851.06335073887 236493.1593300497 210752.5073166168 210107.29786479878 1.2273849224586408 1.0653085986018498 1.1370537048032685 1.0967020306217945 1.102293500569157 1.0506707669489617 1.132045701257806 1.1255827938077139 1.0030708569306013 1.0 17.680766747873292 -1.5228791290812713 0.03521824436119714 0.6710952994129186 1.751207664681014 0.46102424308757395 0.04756186160074667 987.0487584469041 2.666451512249628 24.116435378444553 67.97360006003024 0.029999973487982452 1.5228791290812713 1.0801123652680955 NSS(ph)PINCSR ddPTM_A459_Selumetinib_30min_R2 1 NSSPINCSR 9 0 Q15723-2;Q15723-3;Q15723-1;Q15723;Q15723-4 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 NS(0.003)S(0.997)PINCSR 131.12 0.0036806 5004400.0 23832.0 23331.0 22934.0 27064.0 27018.0 17281.0 20412.0 20699.0 14528.0 23592.0 True False 22507.512847054877 25120.412679010973 21458.451408651184 23377.836511995934 23623.757296015418 19661.30088870089 21361.198445610687 20759.230663096085 17434.005946236048 22910.837660622587 0.9823958940505736 1.0964423497350355 0.9366070209441686 1.0203833163278875 1.0311171353030948 0.8581659553414429 0.9323621755796689 0.9060878074648261 0.7609501758288086 1.0 14.48374258663087 -6.757828571520533 24.9985531463558 0.8881967636880579 1.0141261160305832 0.4463801906311994 0.06781151775107666 84.40288109365406 584343.0514966362 0.02201156423439518 0.021192853860495856 1.7465114149886527e-07 6.757828571520533 0.12592935234252534 NSS(ph)PPPSPNK ddPTM_A459_Selumetinib_30min_R2 1 NSSPPPSPNK 10 0 P20020-6;P20020;P20020-4;P20020-1;A0A0U1RQU3;E7ERY9 P20020-6 ATP2B1 Plasma membrane calcium-transporting ATPase 1;Calcium-transporting ATPase 1 NSS(1)PPPSPNK 137.01 0.0017935 5492700.0 53471.0 15158.0 26854.0 34961.0 18067.0 13676.0 53833.0 37877.0 23255.0 18836.0 True False 50499.29588137262 16320.569859348003 25126.24287642449 30199.25148891107 15797.261938970692 15559.744861632624 56336.3411680658 37987.21579912509 27906.649798989514 18292.155738194608 2.7607077374663103 0.8922168656846787 1.3736075307931088 1.6509399942322853 0.8636085415556299 0.850623900448397 3.079808742850014 2.076694313279138 1.5256074898115772 1.0 14.15893748686866 -7.216365922346535 24.999966491022473 2.0102565588593713 1.3616131757167904 0.10596385417935061 0.7193491860509045 819.9838050835874 454803.94598190475 0.2694239874851398 0.2086941188413143 6.076228223910343e-08 7.216365922346535 -0.6486433831425809 NSS(ph)QDDLFPTSDTPR ddPTM_A459_Selumetinib_30min_R1 2 NSSQDDLFPTSDTPR 15 0 Q9H6T3-3;Q9H6T3-2;Q9H6T3 Q9H6T3-3 RPAP3 RNA polymerase II-associated protein 3 1 NS(0.002)S(0.998)QDDLFPTSDTPR;NS(0.001)S(0.999)QDDLFPTSDTPR 189.52 1.9115e-05 5573700.0 1341.18 1267.1 1143.88 1508.26 1355.96 1291.44 1236.84 946.29 860.1400000000001 1017.32 True False 1372.426884518007 1118.7473429411916 988.5473788830773 1244.8707045466786 1233.3136574141824 1278.4492861337017 1143.5441630144032 921.1913152168813 1459.5947578599805 1147.902931535952 1.1955948946672963 0.9746009982257396 0.8611768048717771 1.084473843864985 1.074405878347176 1.113725952788597 0.9962028422423171 0.8024993141051404 1.2715315187033884 1.0 10.164784935288449 -4.753585095821017 24.87747236829145 1.0146355014267332 1.1955952438740125 0.1509608516975749 0.12448792704712415 518.5583524992811 1642329.1622883184 0.030237709794662778 0.3192962082338229 1.7636601583962897e-05 4.753585095821017 0.1809597424472793 NSS(ph)QDDLFPTSDTPR ddPTM_A459_Selumetinib_30min_R2 1 NSSQDDLFPTSDTPR 15 0 Q9H6T3-3;Q9H6T3-2;Q9H6T3 Q9H6T3-3 RPAP3 RNA polymerase II-associated protein 3 1 NS(0.234)S(0.766)QDDLFPTSDTPR 157.83 0.00016422 0.0 8390.0 8905.4 10919.0 13638.0 14328.0 11093.0 8828.3 9543.4 12227.0 9559.1 True False 7923.717387831088 9588.415544625788 10216.483427708316 11780.480873137769 12527.988546054812 12620.960057772063 9238.833442944573 9571.169714005082 14672.741650924307 9283.103945475475 0.8535633592353618 1.032888956209428 1.1005460552542625 1.269023910787889 1.34954737333959 1.3595625053755256 0.995231066807942 1.031031190668721 1.5805857326498758 1.0 13.180391557472914 -5.070034737975682 1.5176049476560118 1.2260489282716192 0.8229454016699903 0.30710524794375205 0.17607450929564758 0.8466391680732754 2.683369681857546 0.05195277231948835 0.43634676288576935 8.510699608234224e-06 5.070034737975682 -0.40310352660162885 NSS(ph)SPVSLDAALPESSNVYR ddPTM_A459_Selumetinib_30min_R2 1 NSSSPVSLDAALPESSNVYR 20 0 Q70EL1;Q70EL1-7;H7C1E9;Q70EL1-6;H7C296;R4GN32 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 NS(0.001)S(0.5)S(0.5)PVSLDAALPESSNVYR 296.01 1.4296e-86 7217400.0 30350.0 23727.0 33696.0 35902.0 40671.0 30934.0 38095.0 35696.0 29882.0 31955.0 True False 28663.268500676222 25546.784605670295 31528.036045430836 31012.085665595536 35561.54537664678 35194.87770910674 39866.49298381045 35799.86945020909 35859.23497284043 31032.376120939098 0.9236569055804812 0.8232300519338125 1.0159723484453802 0.9993461520553732 1.14594980539217 1.1341341562742595 1.2846742005331178 1.1536296579639973 1.1555426768833343 1.0 14.921486546498322 -5.877436610386948 1.2401192260238016 1.1652286619057233 0.8741658528088533 0.6567408608510674 0.07525642951173384 0.2624535599142491 0.8129535120538126 0.026289070135249167 0.058206588434887505 1.326060655420015e-06 5.877436610386948 -0.29106280909687 NSS(ph)SPVSPASVPGQR ddPTM_A459_Selumetinib_30min_R1 2 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 NSS(0.5)S(0.5)PVSPASVPGQR;NS(0.014)S(0.493)S(0.493)PVSPASVPGQR 220.97 1.8865e-09 176612000.0 7754.1 8770.3 8413.9 9041.0 7389.7 6734.4 7828.9 7554.700000000001 3867.4 6599.1 True False 7934.755443147887 7743.469198798149 7271.338594244437 7462.159070588969 6721.302939757498 6666.658050345969 7238.359769916447 7354.324814875964 6562.695336279776 7446.158765677376 1.065617279035557 1.0399280276551726 0.9765220999263725 1.002148799859781 0.9026537240568845 0.8953150557406231 0.9720931285109355 0.9876669362430579 0.8813531302246909 1.0 12.862280662067402 -5.341633571828062 1.1856820089323543 0.9414151502501811 1.0759433166369798 0.5247501902635234 0.04034074157131191 0.5736289174915998 1.2433116310889059 0.013439854339590189 0.07501243238584884 4.553721101519708e-06 5.341633571828062 0.13452816638679876 NSS(ph)YFVEWIPNNVK ddPTM_A459_Selumetinib_30min_R1 2 NSSYFVEWIPNNVK 14 0 P04350;K7ESM5;Q9BUF5;P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;Q9BVA1;Q13885 P04350;P68371;P07437;A0A0B4J269;Q9BVA1 TUBB4A;TUBB6;TUBB4B;TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta-4A chain;Tubulin beta-6 chain;Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 1 NS(0.009)S(0.991)YFVEWIPNNVK;NS(0.002)S(0.998)YFVEWIPNNVK 238.67 1.9567e-19 33197000.0 3187.5 4560.3 5465.1 5799.8 4897.4 4260.4 5206.3 4790.0 2405.26 3717.4 True False 3261.7625482046765 4026.3779559740474 4722.969437645477 4786.973805729667 4454.431034706197 4217.544244133695 4813.584599383821 4662.953639887204 4081.550546760175 4194.5645005423585 0.7776164957727864 0.9599036933282193 1.1259737302966246 1.1412326130902768 1.0619531620339222 1.005478457558196 1.1475767266807848 1.1116657377146741 0.9730570470980788 1.0 12.034305315703136 -4.886411645441869 2.826179053513646 1.0769058766721296 0.7563772105801237 0.6948211222856855 0.05961407477284125 0.1826874724420905 2.3732172717670044 0.015536611015064969 0.12225131027494211 1.2989377979063107e-05 4.886411645441869 -0.3205286660920058 NSS(ph)YFVEWIPNNVK ddPTM_A459_Selumetinib_30min_R2 1 NSSYFVEWIPNNVK 14 0 P04350;K7ESM5;Q9BUF5;P68371;P07437;Q5JP53;Q5ST81;A0A0B4J269;Q13509;Q13509-2;Q9BVA1;Q13885 P04350;P68371;P07437;A0A0B4J269;Q9BVA1 TUBB4A;TUBB6;TUBB4B;TUBB;TUBB3;TUBB2B;TUBB2A Tubulin beta-4A chain;Tubulin beta-6 chain;Tubulin beta-4B chain;Tubulin beta chain;Tubulin beta-3 chain;Tubulin beta-2B chain;Tubulin beta-2A chain 1 NS(0.029)S(0.971)YFVEWIPNNVK 183.7 7.737e-05 4276700.0 24166.0 26406.0 28929.0 31507.0 30355.0 17962.0 23034.0 28012.0 20119.0 25187.0 True False 22822.950464162826 28431.255291327572 27067.73963551366 27215.692247393406 26541.533522856887 20436.102457198394 24105.126641005107 28093.510282363775 24143.362171828423 24459.785866314916 0.9330805506189538 1.1623673014440414 1.1066221014138278 1.1126709120080163 1.0851089894212391 0.8354980116707487 0.9855003135657768 1.1485591262290273 0.9870635133023686 1.0 14.578124153367414 -6.58116327449314 24.99996404882185 0.9958071160155536 1.0881909548969069 0.19420371359034727 0.0892932198538847 134.21460413102943 57567.41921994995 0.030308626659020222 0.03030862919647673 2.623232144895608e-07 6.58116327449314 0.09238383888135326 NSSCGGGISSSSS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 NSSCGGGISSSSSSR 15 0 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 NSSCGGGISSS(0.01)S(0.067)S(0.461)S(0.461)R 130.87 0.00075968 1877800.0 6409.7 4869.4 3868.4 4405.0 3665.3 4031.3 3672.2 3707.8 4156.3 3663.3 True False 6053.474534062088 5242.867322411215 3619.5113555954617 3805.0314009511553 3204.832245802252 4586.574982502164 3842.964576326257 3718.5890841406654 4987.676136725012 3557.5310106035395 1.7015943124653492 1.4737376306163967 1.01742229226033 1.069570831458649 0.9008585550624754 1.2892579063489444 1.0802336128264116 1.0452724299681655 1.4020049640772763 1.0 11.796660617281434 -5.075671434544768 3.329653937164876 1.1004792767040965 1.6766699835818142 0.6759393361431442 0.13866890117590397 0.13606869368120858 2.815887566315424 0.03568547798961235 0.1344849306225395 8.400953202049665e-06 5.075671434544768 0.5761907068777177 NSSEAS(ph)SGDFLDLK ddPTM_A459_Selumetinib_30min_R1 1 NSSEASSGDFLDLK 14 0 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 NS(0.004)S(0.015)EAS(0.873)S(0.108)GDFLDLK 163.02 0.00027126 34189000.0 5720.1 8047.3 4083.7 4206.4 4678.4 5737.6 6808.4 6817.1 4040.6 7560.7 True False 5853.367200622925 7105.1183749117245 3529.1559701584297 3471.831203907247 4255.239546038607 5679.88495332398 6294.836906525708 6636.28836293842 6856.603086252283 8531.189492454558 0.6861138421318572 0.8328402951541368 0.4136768938586823 0.4069574596810821 0.49878619503202565 0.6657787824719608 0.7378615739450167 0.7778854717513788 0.8037100913438426 1.0 13.058531193289449 -8.004378460999373 0.8479473110525063 0.9699518685548072 0.571698855819849 0.5347127377707379 0.12438100595669568 0.5164887963013622 0.72315119624743 0.13085934034104332 0.052309886595126184 9.899688717472168e-09 8.004378460999373 -0.39825301273495817 NSSLGS(ph)PSNLCGS(ph)PPGSIR ddPTM_A459_Selumetinib_30min_R2 4 NSSLGSPSNLCGSPPGSIR 19 0 Q9C0B0 Q9C0B0 UNK RING finger protein unkempt homolog 2 NSS(0.001)LGS(0.999)PS(0.001)NLCGS(0.926)PPGS(0.074)IR;NSS(0.001)LGS(0.988)PS(0.011)NLCGS(0.947)PPGS(0.053)IR;NS(0.001)S(0.063)LGS(0.934)PS(0.002)NLCGS(0.477)PPGS(0.523)IR;NSS(0.001)LGS(0.988)PS(0.021)NLCGS(0.98)PPGS(0.009)IR 161.64 2.4012e-05 19801900.0 109994.0 104621.0 112907.0 113732.0 116616.0 87664.0 97272.0 92123.0 72278.0 99064.0 True False 103880.97382086921 112645.09429046392 105642.68654384692 98241.50540135693 101965.6555197325 99738.92026544025 101795.34074081141 92391.06267821637 86735.61961605506 96203.76492081699 1.0798015431763108 1.1709011012529436 1.0981138485671418 1.021181504509903 1.0598925686916514 1.0367465384284384 1.0581222140796331 0.9603684715900801 0.90158238284588 1.0 16.553805734317194 -6.7255882425102165 0.5355067335388998 0.9517354054518428 1.1304381294071852 0.6168201948834581 0.04388825780158817 0.6677670301820279 0.4118957287252691 0.039915036499117075 0.05161054691864248 1.8810994545214001e-07 6.7255882425102165 0.17870272395534248 NSSLGS(ph)PSNLCGSPPGS(ph)IR ddPTM_A459_Selumetinib_30min_R1 1 NSSLGSPSNLCGSPPGSIR 19 0 Q9C0B0 Q9C0B0 UNK RING finger protein unkempt homolog 2 NS(0.048)S(0.346)LGS(0.52)PS(0.085)NLCGS(0.144)PPGS(0.857)IR 106.42 0.014974 8123200.0 2206.0 2819.7 3102.1 3348.8 2653.9 2277.7 2629.3 2487.8 1622.8 1925.1 True False 2257.395507871221 2489.5682131570343 2680.851858615583 2763.994944761458 2413.8552135841014 2254.7884059861317 2430.969784138424 2421.8154624867184 2753.773075377468 2172.2053370619483 1.0392182862990744 1.1461016924506504 1.234161344176427 1.2724372312333716 1.1112463321948194 1.0380180766132738 1.1191252238733893 1.1149109253927092 1.2677314747334747 1.0 11.084944771210862 -6.427403970105276 24.999972228238004 1.1112306487917534 1.1774817211853363 0.11660356279362016 0.08638946258724456 120.05395211789721 31426.046131007446 0.0277166572282261 0.03142773258226987 3.737627615477159e-07 6.427403970105276 0.06625107239358297 NSSLGSPS(ph)NLCGSPPGSIR ddPTM_A459_Selumetinib_30min_R2 1 NSSLGSPSNLCGSPPGSIR 19 0 Q9C0B0 Q9C0B0 UNK RING finger protein unkempt homolog 1 NSSLGS(0.002)PS(0.574)NLCGS(0.424)PPGSIR 145.61 5.0088e-05 75299000.0 51452.0 43038.0 62365.0 55078.0 54024.0 42257.0 39632.0 38663.0 39300.0 46885.0 True False 48592.503818675206 46338.876211018585 58352.50379787792 47576.281385150454 47237.02213931218 48077.518179146646 41474.966529318175 38775.502928995775 47161.09813374706 45531.308228140486 1.0672327615801462 1.0177365424870217 1.2815907574079617 1.0449135602861084 1.0374624401878592 1.0559221786083555 0.9109109345486519 0.8516228599166561 1.035794928128142 1.0 15.474571291731861 -6.877908955431386 1.6004365160056042 0.9398942279485085 1.1041304944043342 0.3785893710636743 0.08369232310065508 0.3818744676690723 2.014632324145042 0.03909845537139383 0.03236241364941913 1.3246191964317425e-07 6.877908955431386 0.16423626645582567 NSSLGSPSNLCGS(ph)PPGSIR ddPTM_A459_Selumetinib_30min_R1 4 NSSLGSPSNLCGSPPGSIR 19 0 Q9C0B0 Q9C0B0 UNK RING finger protein unkempt homolog 1 NSSLGSPS(0.006)NLCGS(0.993)PPGS(0.002)IR;NS(0.007)S(0.023)LGSPS(0.137)NLCGS(0.828)PPGS(0.004)IR;NSSLGSPSNLCGS(1)PPGSIR;NS(0.001)S(0.001)LGS(0.009)PS(0.004)NLCGS(0.984)PPGSIR 205.33 4.1528e-16 109219000.0 8644.5 9480.900000000001 10681.599999999999 11756.399999999998 8820.4 10156.9 9839.0 8344.099999999999 5671.97 7692.1 True False 8845.900030731083 8370.87182044917 9231.0973898289 9703.365434959871 8022.596377368097 10054.730807727337 9096.836308575652 8122.787362543381 9624.918825701709 8679.455962398955 1.0191767858553802 0.96444660318727 1.063557143422325 1.1179693147815584 0.9243201892058098 1.1584517337591587 1.048088307376046 0.9358636529447044 1.1089311204986438 1.0 13.083388900494613 -5.2671824619713155 24.949584116143484 1.0448656283766602 0.9918116939091252 0.07821850309244893 0.07254884839993134 1089.9093325921287 4734886.225987288 0.018360493943417832 0.039865345977238606 5.405271812708356e-06 5.2671824619713155 -0.053053934467535036 NSSLGSPSNLCGS(ph)PPGSIR ddPTM_A459_Selumetinib_30min_R2 3 NSSLGSPSNLCGSPPGSIR 19 0 Q9C0B0 Q9C0B0 UNK RING finger protein unkempt homolog 1 NSS(0.004)LGS(0.231)PS(0.231)NLCGS(0.534)PPGSIR;NSSLGS(0.001)PS(0.008)NLCGS(0.859)PPGS(0.132)IR;NSSLGS(0.105)PS(0.438)NLCGS(0.456)PPGSIR 139.7 0.00012883 88802900.0 238070.0 238754.0 266694.0 282533.0 264305.0 176754.0 205051.0 186924.0 135628.0 240096.0 True False 224839.02246971935 257065.66408489057 249535.19839447254 244051.5180033897 231100.6429833202 201100.25908694157 214586.2778008483 187467.91789306575 162757.38976294742 233163.80463567493 0.964296421655311 1.1025110200383073 1.0702141302951305 1.0466955554474981 0.9911514497047323 0.8624848929754189 0.920324139229695 0.8040180944293206 0.6980388316156553 1.0 17.83098432247126 -6.735574126937577 1.4675007657037835 0.8333486754433949 1.0556016180379422 0.5518294764247099 0.0805105980373851 0.2794972070039686 1.254278866932174 0.035499690986794896 0.03286221011563489 1.8383401526032507e-07 6.735574126937577 0.2222529425945473 NSSNKPAVTTKS(ph)PAVKPAAAPK ddPTM_A459_Selumetinib_30min_R1 1 NSSNKPAVTTKSPAVKPAAAPK 22 3 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 NSSNKPAVT(0.002)T(0.017)KS(0.98)PAVKPAAAPK 63.639 0.0059746 28696000.0 3163.6 3093.0 4597.9 4643.4 2944.6 3112.2 3040.3 3119.5 2149.2 2797.2 True False 3237.30572470598 2730.870122103312 3973.5304344568513 3832.5173574132095 2678.2614499113533 3080.8940936515096 2810.967723240426 3036.760726435935 3647.035428642626 3156.2478670353134 1.0256817148352815 0.8652267620123378 1.2589411864503586 1.214263745709275 0.8485586565883572 0.9761255210115725 0.890604236948218 0.9621426625432895 1.1554971543056638 1.0 11.623994792453528 -6.264197699707926 24.996071458780374 0.9663828607460124 1.0868934373526953 0.1780353639728104 0.12463498722432871 475.5032134780152 4309036.259413798 0.04039022117904697 0.0478255741675673 5.44254840535686e-07 6.264197699707926 0.12051057660668285 NSSNKPAVTTKS(ph)PAVKPAAAPK ddPTM_A459_Selumetinib_30min_R2 1 NSSNKPAVTTKSPAVKPAAAPK 22 3 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 NSSNKPAVT(0.009)T(0.155)KS(0.836)PAVKPAAAPK 81.003 0.00077609 27863000.0 145320.0 167970.0 131820.0 153920.0 142070.0 107810.0 102880.0 103630.0 69442.0 179060.0 True False 137243.69616205167 180852.75889132402 123338.84471476436 132955.83047318988 124221.89647808536 122659.84889826058 107664.12385285264 103931.54614312988 83332.34037159434 173890.07254624763 0.789255500054786 1.040040735178971 0.7092920424307793 0.7645970153806744 0.7143702608154783 0.7053873007364356 0.6191504913209948 0.5976853343107804 0.4792242544463334 1.0 17.407816045395734 -5.723095633954795 1.0273075862188334 0.654412016436443 0.9175116686000374 0.21654513805381082 0.1444361092019143 0.8107932472540111 1.5958587466481031 0.05320268954851466 0.16720957995498442 1.8919269603922159e-06 5.723095633954795 0.26309965216359443 NSSNTSVGS(ph)PSNTIGR ddPTM_A459_Selumetinib_30min_R1 4 NSSNTSVGSPSNTIGR 16 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 NSSNT(0.005)S(0.017)VGS(0.61)PS(0.184)NT(0.184)IGR;NSSNT(0.001)S(0.003)VGS(0.966)PS(0.03)NTIGR;NSSNT(0.001)SVGS(0.996)PS(0.003)NTIGR;NSSNTS(0.001)VGS(0.768)PS(0.231)NTIGR 271.27 1.4966999999999994e-50 275319000.0 15359.900000000001 17090.0 20137.600000000002 20247.300000000003 18333.5 14989.1 15456.1 14957.7 8317.7 14204.3 True False 15717.755784837349 15089.09485507455 17403.024527918893 16711.48914389294 16675.23816204233 14838.323263013894 14290.233933222498 14560.973206542967 14114.529399227984 16027.56026659864 0.9806705152494779 0.9414467706928641 1.0858186922052455 1.0426720515111463 1.0404102611171238 0.9258004971559451 0.8916038183929514 0.9084959260385977 0.8806411683656306 1.0 13.968267213079406 -6.819045902437011 6.168921431231221 0.9126299936483273 1.0189819851601178 0.51081097005734 0.04709996591885615 0.16316707609998055 12.582268866741948 0.01719558749265759 0.015287074045652327 1.5168900324058482e-07 6.819045902437011 0.10635199151179053 NSSNTSVGS(ph)PSNTIGR ddPTM_A459_Selumetinib_30min_R2 5 NSSNTSVGSPSNTIGR 16 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 NSSNT(0.001)S(0.002)VGS(0.978)PS(0.019)NTIGR;NSS(0.011)NT(0.028)S(0.044)VGS(0.871)PS(0.044)NT(0.002)IGR;NSSNTSVGS(0.91)PS(0.082)NT(0.007)IGR;NSSNTSVGS(0.999)PS(0.001)NTIGR;NS(0.002)S(0.332)NT(0.012)S(0.006)VGS(0.594)PS(0.004)NT(0.05)IGR 225.86 2.7104e-12 291624500.0 107477.5 90023.2 92942.9 111043.1 112376.4 72762.9 84645.0 90267.0 65710.2 90173.0 True False 101504.33081652144 96927.68996978886 86963.05500257818 95918.83821996786 98258.67197423743 82785.32899915816 88581.16022088563 90529.66202549372 78854.07609639029 87569.47119240918 1.1591291969035 1.1068662246094605 0.9930750273859874 1.095345637170896 1.122065380049421 0.945367465075366 1.011552987755899 1.033803913541745 0.9004745035302397 1.0 16.41814037910448 -6.759741709446929 24.99999365258407 0.9824345900721534 1.0902628549922568 0.554154529965528 0.0523331919310004 39.47341376951771 581291.7632865036 0.01821919887742168 0.017321715754634932 1.7388346688238465e-07 6.759741709446929 0.10782826492010344 NSSNTSVGSPS(ph)NTIGR ddPTM_A459_Selumetinib_30min_R2 1 NSSNTSVGSPSNTIGR 16 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 NSSNT(0.009)S(0.01)VGS(0.094)PS(0.88)NT(0.007)IGR 89.374 0.013205 9726700.0 15738.0 10860.0 16767.0 16444.0 17105.0 10626.0 13490.0 13446.0 11191.0 12965.0 True False 14863.344964205682 11692.92707959621 15688.229474529291 14204.29883251778 14956.116979359811 12089.635046775973 14117.31172992789 13485.125633894873 13429.512702665723 12590.666762884535 1.180504991842106 0.9286980030370804 1.2460205460107898 1.1281609703459072 1.1878733081434798 0.960206101428597 1.1212521144268295 1.0710414220196085 1.0666244255033406 1.0 13.62006706530979 -6.744762773002122 24.99245514968654 1.0531040706453016 1.1287029231589476 0.2059807241415752 0.08749233451643204 476.7225054010755 714440.1197874064 0.02843186546808313 0.028357393231862472 1.7998537904270434e-07 6.744762773002122 0.07559885251364595 NSSPS(ph)DSKPPFSQGQEK ddPTM_A459_Selumetinib_30min_R2 1 NSSPSDSKPPFSQGQEK 17 1 Q70EL1;Q70EL1-7;Q70EL1-9;Q70EL1-10;Q70EL1-8 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 NS(0.003)S(0.054)PS(0.927)DS(0.016)KPPFSQGQEK 80.488 0.009089 4338300.0 29376.0 31877.0 28369.0 32139.0 26483.0 23938.0 24494.0 26934.0 19914.0 25215.0 True False 27743.39952144528 34321.863399289905 26543.769425831786 27761.612757132625 23155.968778976097 27235.242212471614 25633.019533940213 27012.37348083625 23897.35644364985 24486.977433562155 1.1329858736840193 1.4016374006310772 1.0839953398842344 1.1337296664096326 0.945644224233173 1.1122337285753632 1.0468021054655474 1.1031322078899275 0.9759210383759261 1.0 14.579727084413818 -5.411035366205679 6.541899969994993 1.0527453858739677 1.2663721012450357 0.5247941456264493 0.08308598052145696 0.16717610792149892 8.54982397375207 0.020295093104058384 0.04265550652066252 3.881187587579328e-06 5.411035366205679 0.21362671537106803 NSSQSGGKPGS(ph)SPITK ddPTM_A459_Selumetinib_30min_R1 1 NSSQSGGKPGSSPITK 16 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NSSQSGGKPGS(0.597)S(0.397)PIT(0.006)K 63.93600000000001 0.032852 118570000.0 5175.1 6047.9 6869.7 6888.6 4913.6 5110.0 5995.7 5536.1 3165.1 4999.7 True False 5295.669761008324 5339.809056407566 5936.832472560996 5685.635325036959 4469.165747566541 5058.598039508774 5543.439521834237 5389.264644212845 5370.943530242315 5641.460196202085 0.9387055082961406 0.9465295988443567 1.0523574156488351 1.0078304423497686 0.7922001737378648 0.8966823949080235 0.9826249462091681 0.9552960504517923 0.9520484667884592 1.0 12.46185291274091 -10.942682536781007 8.322905507700964 1.0000007822427213 0.9472454709956776 0.055578695169907655 0.06536647445621273 1.027024864962141e-06 7.16332229352898e-08 0.06850938331174022 0.016615719746998985 1.1410835989937586e-11 10.942682536781007 -0.05275531124704369 NSSQSGGKPGSS(ph)PITK ddPTM_A459_Selumetinib_30min_R1 1 NSSQSGGKPGSSPITK 16 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NSSQSGGKPGS(0.363)S(0.61)PIT(0.027)K 101.05 0.0031253 108020000.0 5952.3 7259.6 8508.5 8874.6 5944.6 6507.1 7075.4 6367.2 3683.8 5630.2 True False 6090.97700884038 6409.642657103518 7353.092433845042 7324.817706874116 5406.911979604373 6441.644481974079 6541.6968815627815 6198.321172419584 6251.139545893223 6352.891012792163 0.9587724701361328 1.008933199734905 1.1574403557433737 1.1529896691325074 0.8510947171479931 1.0139705637957903 1.029719676977055 0.9756693700456475 0.9839834389266158 1.0 12.633197553816059 -6.242174119159677 24.999232182135547 0.9791336289522382 1.0714843192886527 0.29080202806625244 0.07161398726592626 1187.312452423564 1540695.7695776194 0.022481178473063954 0.02897979317422392 5.725664292354753e-07 6.242174119159677 0.09235069033641452 NSSQSGGKPGSS(ph)PITK ddPTM_A459_Selumetinib_30min_R2 2 NSSQSGGKPGSSPITK 16 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NSSQS(0.001)GGKPGS(0.206)S(0.784)PIT(0.01)K;NSSQSGGKPGS(0.024)S(0.971)PIT(0.005)K 122.75 0.006747100000000001 155668000.0 153715.0 129578.0 130563.0 141021.0 144979.0 109893.0 130628.0 124333.0 98619.0 102094.0 True False 145172.13566989935 139516.21594106095 122162.71872624589 121813.696525206 126765.44189129546 125029.76324066936 136702.46083447142 124694.78844556377 118345.55564508923 99146.28094793147 1.4642216962846968 1.407175484618838 1.2321462545872188 1.2286259793161454 1.2785698130005372 1.2610635723828216 1.3787956494935325 1.257684980751316 1.193645939248499 1.0 16.59727103643518 -14.522878745279117 0.10933489798285749 0.05013840864598824 1.4696576384464384 0.6788207775805148 0.06953784041886185 116.38617279771486 0.8442058795562667 24.80882939262042 0.9996763727945338 3.000000000008431e-15 14.522878745279117 1.4195192298004502 NSSQSLMVPQS(ph)GSPEPESIR ddPTM_A459_Selumetinib_30min_R2 3 NSSQSLMVPQSGSPEPESIR 20 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970;A0A075B6R8;B7ZB24;H0YGQ3 F5H1U9 MPDZ Multiple PDZ domain protein 1 NSSQSLMVPQS(0.772)GS(0.228)PEPESIR;NSSQSLMVPQS(0.705)GS(0.282)PEPES(0.013)IR;NSSQSLMVPQS(0.793)GS(0.207)PEPESIR 190.8 1.4874e-15 38158000.0 106354.0 86003.0 115834.0 116134.0 107987.0 84598.0 99685.0 96161.0 73250.0 95801.0 True False 100443.27044879457 92599.15355676932 108381.3665505232 100316.3488576758 94420.7076439713 96250.6065958173 104320.55002208026 96440.81258968952 87902.04677600418 93034.976209109 1.0796291302642398 0.9953154967078177 1.1649529130519802 1.0782648950455032 1.0148947362736749 1.0345636718332762 1.1213046348032096 1.0366081286776 0.9448279599538152 1.0 16.505485574448628 -8.068539244592 5.3757674650215925 0.9753554703478662 1.0682852289959317 0.38874474256055 0.04825154521255253 0.23541238440346726 12.776663236266664 0.03376070017627603 0.012522605464600184 8.540056725523962e-09 8.068539244592 0.09292975864806552 NSSQSLMVPQSGS(ph)PEPESIR ddPTM_A459_Selumetinib_30min_R1 2 NSSQSLMVPQSGSPEPESIR 20 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970;A0A075B6R8;B7ZB24;H0YGQ3 F5H1U9 MPDZ Multiple PDZ domain protein 1 NSSQSLMVPQS(0.198)GS(0.802)PEPESIR;NSSQSLMVPQS(0.149)GS(0.851)PEPESIR 270.73 5.314699999999998e-59 29296000.0 6361.6 6701.7 7876.6 7345.6 6636.9 6264.8 6522.9 5719.5 3578.2 6048.0 True False 6509.812902481214 5917.061848464194 6807.0009830668005 6062.8288539894165 6036.593566839862 6201.781799983282 6030.872401383083 5567.800280445687 6071.944058612066 6824.319712508785 0.9539138224355038 0.8670551934456392 0.9974622042677397 0.8884151255218043 0.8845707442127831 0.9087765610710752 0.8837323946486072 0.8158762360210157 0.8897508197751 1.0 12.73646952171194 -5.928669908325863 24.999803322461773 0.8877009479999927 0.9340191611123979 0.11234240150681762 0.05210449973933928 87.07784462638095 30516.963404959235 0.014094717574050767 0.0209058428016196 1.1785013698617588e-06 5.928669908325863 0.04631821311240525 NSSQSLMVPQSGS(ph)PEPESIR ddPTM_A459_Selumetinib_30min_R2 2 NSSQSLMVPQSGSPEPESIR 20 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970;A0A075B6R8;B7ZB24;H0YGQ3 F5H1U9 MPDZ Multiple PDZ domain protein 1 NSSQSLMVPQS(0.269)GS(0.73)PEPES(0.001)IR;NSSQSLMVPQS(0.045)GS(0.952)PEPES(0.003)IR 139.78 7.336e-05 19700000.0 111363.4 87508.0 96595.0 114056.0 109914.0 76688.7 93959.0 97544.0 65010.6 88299.0 True False 105174.26805101178 94219.58221743141 90380.1828646841 98521.37604242579 96105.6206763726 87251.87231429397 98328.27967622652 97827.83689072158 78014.53654793321 85749.57844164626 1.2265281061712074 1.0987760398326518 1.054001483239816 1.148942978296633 1.1207707655586174 1.017519548200112 1.1466911145591256 1.1408550183986588 0.9097949863511359 1.0 16.387841958337624 -1.522878745280636 0.08533562885642798 0.9061907200119195 1.6030312363421781 0.3459465582014881 0.07047186861032671 226.47834261329598 1.4042287531944657 1.6039053742857579 18.518277925083726 0.02999999999997938 1.522878745280636 0.6968405163302587 NSSS(ph)PVS(ph)PASVPGQR ddPTM_A459_Selumetinib_30min_R1 1 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 2 NS(0.116)S(0.048)S(0.843)PVS(0.991)PAS(0.001)VPGQR 124.5 0.023998 5017400.0 1385.2 1961.1 1716.3 1767.7 1337.9 1499.5 1655.4 1424.1 887.28 1462.2 True False 1417.4724648699985 1731.4935003093433 1483.2358869610666 1459.0043788386376 1216.8871812254306 1484.4163914370663 1530.5318452298131 1386.3282418712658 1505.6493556328078 1649.887613034118 0.8591327395102315 1.0494614824855575 0.8989920739106699 0.8843053110481573 0.7375576200536433 0.899707579904335 0.9276582435910217 0.8402561670984544 0.9125769196266295 1.0 10.688152039048003 -5.5043834554087505 23.379401879431235 0.8767177704731791 0.9592795496468389 0.10140821693012747 0.0765000530607991 554.1774320523266 700517.0103852021 0.019492832144318142 0.039337956200233434 3.130520446031575e-06 5.5043834554087505 0.08256177917365981 NSSS(ph)PVS(ph)PASVPGQR ddPTM_A459_Selumetinib_30min_R2 1 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 2 NS(0.02)S(0.397)S(0.583)PVS(0.998)PAS(0.002)VPGQR 132.15 0.011803 7191600.0 27132.0 23446.0 27817.0 26348.0 26884.0 20954.0 22437.0 21451.0 19006.0 22465.0 True False 25624.11205800157 25244.23280922769 26027.28450485961 22759.356947164804 23506.591573990605 23840.22329852661 23480.364958072056 21513.418858595778 22807.73107201009 21816.37707892024 1.1745356236421354 1.157123051087138 1.193015889425935 1.0432234859543066 1.0774745728383799 1.0927672918507576 1.0762724201700575 0.9861132662298365 1.04544081675448 1.0 14.413123920979933 -5.515514630660001 0.3313000979818256 0.998164197426849 1.2714871234657232 0.7253584305975745 0.03530762112223545 2.3096259779228125 0.29572278824704396 0.039602386777436396 0.24399913397236075 3.0513032340699234e-06 5.515514630660001 0.2733229260388742 NSSS(ph)PVSLDAALPESSNVYR ddPTM_A459_Selumetinib_30min_R1 3 NSSSPVSLDAALPESSNVYR 20 0 Q70EL1;Q70EL1-7;H7C1E9;Q70EL1-6;H7C296;R4GN32 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 NSSS(0.996)PVS(0.004)LDAALPESSNVYR;NS(0.011)S(0.46)S(0.529)PVS(0.001)LDAALPESSNVYR;NSS(0.085)S(0.909)PVS(0.006)LDAALPESSNVYR 208.87 9.7893e-17 17786700.0 2489.74 2827.66 1902.25 2626.45 2441.25 2312.91 2516.0699999999997 2244.99 1142.49 2390.5299999999997 True False 2547.746097809291 2496.596252656529 1643.9348983113043 2167.7898120726036 2220.4393685376945 2289.644225354256 2326.2808142004205 2185.445572444753 1938.7220858318972 2697.377811234068 0.9445269725280644 0.9255641691196088 0.6094566699053529 0.8036656203829399 0.8231844123911692 0.8488407577975622 0.8624230556475632 0.8102111477831493 0.7187432467774766 1.0 11.397341893079998 -6.541867389259583 7.568919110381541 0.8370211795289237 0.8131982054826103 0.008352653752813022 0.1065507240934351 1.37147123898703 372.22412011580946 0.0361834647345877 0.03678431005675869 2.871657301584069e-07 6.541867389259583 -0.023822974046313394 NSSS(ph)PVSLDAALPESSNVYR ddPTM_A459_Selumetinib_30min_R2 1 NSSSPVSLDAALPESSNVYR 20 0 Q70EL1;Q70EL1-7;H7C1E9;Q70EL1-6;H7C296;R4GN32 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 NSS(0.032)S(0.968)PVS(0.001)LDAALPESSNVYR 225.83 5.5253e-21 7650100.0 12419.0 7852.0 10672.0 12677.0 12162.0 8876.4 11518.0 13479.0 10277.0 9497.2 True False 11728.801697195975 8454.223151840652 9985.375138795045 10950.370730955228 10634.100830340498 10099.04352806346 12053.609822484019 13518.221658431425 12332.687163371964 9222.991159310995 1.2716917423644345 0.9166465635506719 1.082661250164421 1.1872906025612278 1.1529991351672204 1.0949857105596434 1.3069089641613063 1.465709055221658 1.3371678396245235 1.0 13.171018999618699 -7.267260555355479 19.146813345078392 1.31625606376945 1.1117464101183603 0.21993884446375667 0.13966417153314165 22.763384227281495 74864.8372798562 0.05525759948765692 0.03868742880815138 5.4042999421543905e-08 7.267260555355479 -0.20450965365108975 NSSS(ph)PVSLDAALPESSNVYRDPSAK ddPTM_A459_Selumetinib_30min_R2 3 NSSSPVSLDAALPESSNVYRDPSAK 25 1 Q70EL1;Q70EL1-7;H7C1E9;Q70EL1-6;H7C296;R4GN32 Q70EL1 USP54 Inactive ubiquitin carboxyl-terminal hydrolase 54 1 NS(0.011)S(0.211)S(0.773)PVS(0.004)LDAALPESSNVYRDPSAK;NS(0.072)S(0.173)S(0.528)PVS(0.227)LDAALPESSNVYRDPSAK;NS(0.056)S(0.164)S(0.751)PVS(0.029)LDAALPESSNVYRDPSAK 126.28 3.9734e-08 26038900.0 74148.0 70667.0 78534.0 83294.0 87614.0 64427.0 61529.0 63011.0 45607.0 78846.0 True False 70027.15099796175 76086.93166978152 73481.20794135406 71949.21350983552 76607.14604090218 73301.23443992439 64390.220417400524 63194.35157796739 54729.674366050946 76569.51111348961 0.9145565902095036 0.993697498695103 0.9596666724493234 0.939658781459294 1.0004915132258947 0.957316213385233 0.8409381159814744 0.8253200348151909 0.7147711088938762 1.0 16.224482425465474 -7.2728125688325465 4.575449912717906 0.8289376666525654 0.9638293237448922 0.3956184491833803 0.06898439094405996 0.17602126470378548 10.008586533729053 0.02735263956541759 0.019121898926373167 5.335651198177169e-08 7.2728125688325465 0.13489165709232676 NSSS(ph)PVSPASVPGQR ddPTM_A459_Selumetinib_30min_R1 2 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 NS(0.001)S(0.035)S(0.96)PVS(0.003)PASVPGQR;NS(0.002)S(0.043)S(0.951)PVS(0.004)PASVPGQR 134.88 0.00041266 37100000.0 9685.099999999999 10976.5 10537.6 11714.8 10541.3 10473.1 10315.1 9707.7 6136.3 9095.2 True False 9910.743986075955 9691.36627716359 9106.651798893521 9669.03009403115 9587.841276217672 10367.75012281396 9537.023702265344 9450.22026094635 10412.852922380307 10262.657514750319 0.9657093176724874 0.94433301152595 0.887358053779414 0.9421565593642817 0.9342454683338359 1.010240291845713 0.9292937709904052 0.920835587406452 1.0146351378689307 1.0 13.325116744695547 -6.578976946337252 24.999940552039057 0.9677572717368398 0.9329223549685147 0.23774680009171412 0.03477007951982208 148.78156924167945 66302.60122104023 0.011601346418361538 0.011601347675533473 2.6364713339719433e-07 6.578976946337252 -0.034834916768325064 NSSS(ph)PVSPASVPGQR ddPTM_A459_Selumetinib_30min_R2 4 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 NS(0.001)S(0.026)S(0.973)PVSPASVPGQR;NS(0.001)S(0.228)S(0.771)PVSPASVPGQR;NS(0.005)S(0.483)S(0.511)PVSPASVPGQR;NS(0.003)S(0.052)S(0.908)PVS(0.017)PAS(0.02)VPGQR 207.21 1.881e-06 305735000.0 191908.0 186238.0 199307.0 213576.0 210781.0 158703.0 162675.0 173310.0 126917.0 179956.0 True False 181242.521628592 200521.85575044606 186483.80460905403 184486.58036084997 184300.80637395143 180562.89768760462 170239.70983439742 173814.30340698513 152303.94635727146 174760.20269816005 1.0370926494153132 1.147411439529975 1.0670839340415654 1.0556555640959573 1.0545925418286999 1.033203755202017 0.9741331676550509 0.9945874445292979 0.8715024588311202 1.0 17.415017158663353 -7.111753614919605 0.9709872492725711 0.9435528545688582 1.084807920321273 0.6247650171927432 0.0417541388431398 0.3408724097615525 0.6476588976470574 0.02777908222111482 0.01807781397154418 7.731190686335014e-08 7.111753614919605 0.14125506575241487 NSSSPVS(ph)PASVPGQR ddPTM_A459_Selumetinib_30min_R1 2 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 NSS(0.006)S(0.006)PVS(0.976)PAS(0.012)VPGQR;NSSS(0.006)PVS(0.993)PAS(0.001)VPGQR 165.66 8.4801e-05 29135000.0 3896.8999999999996 4030.6 4511.8 4966.3 4810.0 3824.7 4185.0 3972.0 2562.7 3529.0 True False 3987.6901879525685 3558.6954782248945 3899.1223415434024 4099.028933996904 4374.9363492744715 3786.226990549748 3869.3220806371714 3866.6496571256703 4348.714727797536 3981.9815253709494 1.0014336235728987 0.8936996456540258 0.9791914695486117 1.0293942620979515 1.0986832363233818 0.9508399188760762 0.971707692761512 0.971036563703159 1.0920981677313089 1.0 11.959270812270592 -5.525585578629816 7.328215417425391 1.0132961048926152 0.9447054449012122 0.22047155308243405 0.052129888370087626 0.1807474833196232 65.10832607844651 0.014296049306570607 0.026367505790773488 2.981360006856898e-06 5.525585578629816 -0.06859065999140301 NSSSPVS(ph)PASVPGQR ddPTM_A459_Selumetinib_30min_R2 4 NSSSPVSPASVPGQR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 NSS(0.005)S(0.128)PVS(0.867)PASVPGQR;NS(0.005)S(0.012)S(0.188)PVS(0.795)PASVPGQR;NS(0.003)S(0.009)S(0.26)PVS(0.726)PAS(0.003)VPGQR;NSS(0.012)S(0.137)PVS(0.849)PAS(0.002)VPGQR 167.95 6.9343e-05 53428300.0 93436.0 104995.0 112013.0 105156.0 120013.0 87666.0 85498.0 79922.0 86272.0 89802.0 True False 88243.2011739434 113047.77888786401 104806.20553053291 90833.5713957819 104935.89401016718 99741.19574728614 89473.82641107301 80154.55978820064 103528.81064108464 87209.18292638296 1.011856758805243 1.2962829726692031 1.201779468786038 1.0415597113489579 1.2032665653885108 1.1437006104217489 1.0259679475107768 0.9191068772638608 1.1871319873330057 1.0 16.41219243501987 -7.24161840241675 5.577447715502565 1.0258514178637974 1.1569021941960869 0.2514105368491949 0.09801938562061 0.23134054704671736 24.83862192361965 0.038083425792720095 0.028117871512719522 5.7329954564270575e-08 7.24161840241675 0.13105077633228945 NSSSSS(ph)SPSERPR ddPTM_A459_Selumetinib_30min_R2 1 NSSSSSSPSERPR 13 1 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 NS(0.001)SSS(0.002)S(0.561)S(0.371)PS(0.066)ERPR 86.641 0.014407 367340.0 836.71 0.0 0.0 2263.0 922.54 360.0 788.18 1360.2 448.77 0.0 True False 790.209007815512 0.0 0.0 1954.7754961072562 806.6422775877583 409.5867322453744 824.8319317490409 1364.1579568067689 538.5365396814676 0.0 0.0 NSSSST(ph)SPVSK ddPTM_A459_Selumetinib_30min_R1 1 NSSSSTSPVSK 11 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 NSSS(0.002)S(0.049)T(0.474)S(0.474)PVSK 151.16 0.0014049000000000002 3342300.0 2213.4 3464.9 3148.5 2953.3 2767.6 3185.9 2463.2 2986.2 3167.0 2637.3 True False 2264.9679134733274 3059.2278972116924 2720.9509934725397 2437.56159530698 2517.2710686594673 3153.852738565756 2277.398840866304 2906.9962754553558 5374.167691471805 2975.8231444774196 0.7611231593774956 1.0280274561642067 0.9143523863379194 0.8191217948656142 0.8459074838943502 1.0598253274623282 0.7653004665592232 0.9768713173866552 1.805943240089812 1.0 11.539073073148666 -8.070741611362092 9.948782471404774 1.4012677139960636 0.8925034024990705 0.5030541275963363 0.2031329339601418 0.4137240856019461 56.22048036056466 0.12379127406680243 0.04675140041296854 8.496858553282978e-09 8.070741611362092 -0.5087643114969932 NSSSSTS(ph)PVSK ddPTM_A459_Selumetinib_30min_R2 1 NSSSSTSPVSK 11 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 NSSSS(0.08)T(0.08)S(0.84)PVSK 99.669 0.017028 1317500.0 10499.0 8569.4 9748.5 8864.7 11922.0 12417.0 19730.0 39886.0 14445.0 27679.0 True False 9915.507610827006 9226.645425036071 9121.292123364276 7657.312567539546 10424.251775967712 14127.329039696717 20647.484094253305 40002.06165651723 17334.4036270223 26879.83535132132 0.36888275100016915 0.3432552805641543 0.33933586289307033 0.2848720041420618 0.3878093611706328 0.5255734960817856 0.7681402740898242 1.4881810522158154 0.6448850374438846 1.0 14.714236680666133 -7.296272144279336 2.4056151145002524 1.0560153078231531 0.35022166567877666 0.6977286333301198 0.19929656259649983 0.15250825211043287 1.7328775895662338 0.0902234263811259 0.05797685292858124 5.055077936743856e-08 7.296272144279336 -0.7057936421443765 NSSTDQGS(ph)DEEGSLQK ddPTM_A459_Selumetinib_30min_R1 1 NSSTDQGSDEEGSLQK 16 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 NSSTDQGS(1)DEEGSLQK 335.98 2.810499999999998e-135 44862000.0 3810.1 4026.1 2766.6 3102.2 2942.9 2993.3 3077.3 3079.6 1696.6 3153.7 True False 3898.8679168359668 3554.7223403168905 2390.910915846 2560.4590055061503 2676.715214611194 2963.1901196989465 2845.176783451558 2997.919004049402 2879.0062852387314 3558.5081146393804 1.0956467685984408 0.9989361344134876 0.6718857562836541 0.7195315910543111 0.7522015205190709 0.8327057362911863 0.799542024857765 0.8424651307429184 0.8090486778419193 1.0 11.797056810481328 -1.5402285637766453 12.35282907740699 0.8384208086397876 0.9699700180010813 0.0 0.1302934515699457 0.0 0.0 0.031330156706878796 0.0 0.028825140726048224 1.5402285637766453 0.13154920936129366 NSSTDQGS(ph)DEEGSLQK ddPTM_A459_Selumetinib_30min_R2 2 NSSTDQGSDEEGSLQK 16 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 NSSTDQGS(1)DEEGSLQK;NSSTDQGS(1)DEEGSLQK 236.68 2.9439999999999998e-21 111007000.0 274040.0 214117.0 251061.0 270210.0 260604.0 254889.0 288140.0 259980.0 171634.0 215864.0 True False 258809.95386903815 230539.08540533145 234908.00859454833 233406.93186175017 227864.59569068011 289997.64609803125 301539.08093857823 260736.49875799436 205965.59585464478 209631.44543797226 1.2345950929657512 1.0997352278122108 1.120576200310822 1.1134156489457248 1.086977171838959 1.3833690145681818 1.4384248522858203 1.2437852451632478 0.9825128831427528 1.0 17.677495616764034 -3.656616769881846 16.241128002491603 1.183231581884686 1.1687689736682068 0.0 0.1450454674161747 0.0 0.0 0.0351655446813301 0.0 0.00022048712272519812 3.656616769881846 -0.014462608216479156 NSSTDQGS(ph)DEEGSLQKEQESAMDK ddPTM_A459_Selumetinib_30min_R1 1 NSSTDQGSDEEGSLQKEQESAMDK 24 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 NS(0.002)S(0.006)T(0.02)DQGS(0.965)DEEGS(0.007)LQKEQESAMDK 95.122 6.4954e-06 8733600.0 886.69 956.47 1196.8 1132.8 989.68 866.53 1182.2 869.03 515.83 916.86 True False 907.3481518016015 844.4860477491605 1034.2811335518293 934.9777452895901 900.1636187421952 857.8134949462897 1093.0257022053202 845.9805013927294 875.3258352674144 1034.5479119726863 0.877047975546595 0.8162851019039671 0.9997421304342026 0.903754900540822 0.8701033643050463 0.8291674895081489 1.0565249705266215 0.8177296494462062 0.8460950190294564 1.0 10.014784745485695 -10.80571429599774 4.95068581327441 1.0000302851540623 0.8924311591290327 0.15871469112405212 0.07538812289275733 2.4894105503979067e-05 3.6061501235851358e-06 0.07210810705115994 0.017483864515830692 1.5641763097949035e-11 10.80571429599774 -0.10759912602502963 NSSTDQGS(ph)DEEGSLQKEQESAMDK ddPTM_A459_Selumetinib_30min_R2 2 NSSTDQGSDEEGSLQKEQESAMDK 24 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 NS(0.002)S(0.012)T(0.028)DQGS(0.848)DEEGS(0.079)LQKEQES(0.03)AMDK;NSS(0.001)T(0.002)DQGS(0.956)DEEGS(0.04)LQKEQES(0.001)AMDK 91.337 2.4542e-05 24888000.0 98091.0 72965.0 86946.0 96816.0 89624.0 58848.0 63879.0 65996.0 40589.0 80920.0 True False 92639.49490938477 78561.18088054658 81351.98901964692 83629.49378308449 78364.6318712741 66953.7778310439 66849.5000738371 66188.03743377404 48707.93415141626 78583.62934459044 1.1788650598352888 0.9997143366343463 1.035228198266552 1.0642101221409341 0.9972131921731938 0.8520066887907473 0.8506797233899823 0.8422624150322513 0.6198229142335894 1.0 16.261941179014777 -6.722458734195115 1.5880930013970582 0.8097084363219045 1.0672241715978246 0.5766673494155358 0.09642196626949276 0.2658371362735932 1.3913989320247127 0.04003252185380835 0.03753983864841665 1.894703536795923e-07 6.722458734195115 0.2575157352759201 NSSTDQGSDEEGS(ph)LQK ddPTM_A459_Selumetinib_30min_R1 1 NSSTDQGSDEEGSLQK 16 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 NSSTDQGS(0.179)DEEGS(0.821)LQK 219.03 1.0235e-10 40952000.0 7794.9 8572.9 5800.0 6069.1 6101.0 6015.7 7312.3 6097.2 3403.5 7053.3 True False 7976.506003764911 7569.180882566913 5012.391857119493 5009.24561611675 5549.165627219035 5955.187519818577 6760.7273238334965 5935.48244950318 5775.490918195231 7958.65975996003 1.0022423679794261 0.9510622530501199 0.6298035106786203 0.6294081877099754 0.6972487572765523 0.7482651224492709 0.8494806321344048 0.7457891942264647 0.7256863708700919 1.0 12.958309785725497 -5.139144851197321 5.881604351080332 0.7414311094442988 0.9885479841971881 0.4280103313681919 0.10311506425598674 0.1925672157789139 8.32754055930286 0.026088012919509695 0.07202533686356184 7.258638180950607e-06 5.139144851197321 0.24711687475288935 NSSTETDQQPHS(ph)PDSSSSVHSIR ddPTM_A459_Selumetinib_30min_R1 2 NSSTETDQQPHSPDSSSSVHSIR 23 0 Q92613 Q92613 JADE3 Protein Jade-3 1 NSSTETDQQPHS(0.999)PDS(0.001)SSSVHSIR;NSST(0.001)ET(0.04)DQQPHS(0.956)PDS(0.002)SSS(0.001)VHSIR 165.34 2.7407e-12 13442500.0 1909.92 1840.79 1250.42 1902.25 4148.9 1869.23 3294.1000000000004 1811.05 175.82100000000003 542.1700000000001 True False 1954.417419942612 1625.269451039947 1080.6198320654073 1570.0577471549468 3773.6327275477856 1850.4272433250467 3045.623384904875 1763.0150708805247 298.3553955422368 611.7628006830175 3.1947307318466485 2.6566987224874987 1.7664033034681463 2.5664485408429827 6.168457322567867 3.0247462599214794 4.978438344901838 2.8818605330565434 0.48769783845819104 1.0 9.256828573719273 -8.180696496254305 4.537397520333875 0.7442215904719578 3.4586760535241403 0.4440472229786757 1.201878457686559 0.2085617807643591 7.556125549891217 0.9556860089053536 0.3290350805145247 6.5963471544073984e-09 8.180696496254305 2.7144544630521823 NSSTETDQQPHS(ph)PDSSSSVHSIR ddPTM_A459_Selumetinib_30min_R2 3 NSSTETDQQPHSPDSSSSVHSIR 23 0 Q92613 Q92613 JADE3 Protein Jade-3 1 NSSTET(0.002)DQQPHS(0.992)PDS(0.001)S(0.001)S(0.002)S(0.002)VHSIR;NSSTET(0.002)DQQPHS(0.884)PDS(0.103)S(0.008)S(0.003)SVHSIR;NSSTETDQQPHS(0.456)PDS(0.145)S(0.145)S(0.145)S(0.109)VHS(0.001)IR 85.387 0.00014427 23783600.0 33538.0 32867.25 59921.0 97215.1 109458.5 61227.6 41689.7 57837.4 60818.9 80069.7 True False 31674.092223251384 35388.06239013431 56065.74809705192 83974.2356745985 95707.34465859427 69661.14613118586 43628.35365657337 58005.697258502994 72984.37942204959 77757.87971493519 0.40734253993769387 0.45510580432322695 0.7210297953415414 1.0799450291398482 1.2308378907637765 0.8958725004664169 0.5610795178124377 0.7459783814985077 0.9386107194488131 1.0 16.24670125993279 -5.394525892209345 3.184573004759804 0.9077640399256502 0.42495320234601097 0.5607375611000543 0.17176280235788624 0.21479163230846599 4.048324686987998 0.05387008582508532 0.12906900694194468 4.031569099089898e-06 5.394525892209345 -0.4828108375796393 NSSTMLYS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 NSSTMLYSR 9 0 Q96DR7;Q96DR7-4 Q96DR7 ARHGEF26 Rho guanine nucleotide exchange factor 26 1 NSSTMLY(0.384)S(0.616)R;NSSTMLY(0.351)S(0.649)R 95.815 0.022039 356358000.0 14376.8 20568.5 12116.7 13253.5 14133.5 13735.2 17354.2 16202.5 8688.6 14750.8 True False 14711.751467616945 18160.330457963762 10471.318692268935 10939.025024007402 12855.127420472088 13597.036358563775 16045.158722053415 15772.757066862709 14743.919609763789 16644.208864959433 0.8838961098709333 1.0910900364988916 0.6291268498987594 0.6572270939856452 0.7723483600074025 0.8169229591434183 0.9640084940193714 0.9476423418399077 0.8858288026416041 1.0 14.022732677259523 -7.2270814708952065 6.558272986239708 0.9450727127330094 0.804135492038187 0.24185142762987444 0.1220452857640942 0.3452743192568972 48.39549820258521 0.05237443720667004 0.03973253926246764 5.9281410597530755e-08 7.2270814708952065 -0.1409372206948224 NSSTMLYS(ph)R ddPTM_A459_Selumetinib_30min_R2 5 NSSTMLYSR 9 0 Q96DR7;Q96DR7-4 Q96DR7 ARHGEF26 Rho guanine nucleotide exchange factor 26 1 NSSTMLY(0.335)S(0.665)R;NSSTMLY(0.351)S(0.649)R;NSSTMLY(0.365)S(0.635)R;NSSTMLY(0.373)S(0.627)R;NSSTMLY(0.17)S(0.83)R 101.6 0.016878 137578600.0 543195.0 371599.0 445743.0 454070.0 447313.0 350025.0 378777.0 389658.0 296490.0 393388.0 True False 513006.3964818722 400099.4484208898 417064.3806682833 392224.8826855607 391117.54191104235 398237.76653940877 396390.8810323866 390791.84026864567 355796.2846227644 382029.8662952276 1.3428436929730192 1.047298872993606 1.0917062184504223 1.0266864381290401 1.0237878669119338 1.0424257412158868 1.0375913403745796 1.0229353114676298 0.9313310712409321 1.0 18.54332590398503 -2.240218814574585 1.2233104710644471 1.0194172261699948 199.9996033742237 0.8587283721130043 0.038663903416644135 319.1383355105416 1.0449176640877103 0.011279312282285804 177543.10311046516 0.005751500811789642 2.240218814574585 198.98018614805372 NSSYPETGVFVINHFTCRS(ph) ddPTM_A459_Selumetinib_30min_R1 1 NSSYPETGVFVINHFTCRS 19 1 Q00537-2;F5H6Z0 Q00537-2 CDK17 Cyclin-dependent kinase 17 1 NSSYPETGVFVINHFT(0.315)CRS(0.685) 118.09 0.00023316 8413900.0 1424.2 1596.4 1739.7 1899.5 1914.9 1289.4 1409.0 1017.1 634.28 961.95 True False 1457.3810889892086 1409.492745853775 1503.4582954880664 1567.7879830310533 1741.6976331030542 1276.4298066815288 1302.7179956075913 990.1232039935855 1076.3268340217032 1085.42565268648 1.3426816340503114 1.2985622206046206 1.3851324517408778 1.4443992355908521 1.604621771000409 1.1759716600785182 1.2001909042625836 0.9121980870297138 0.99161728061037 1.0 10.084045195162457 -7.33321786286813 1.7607030401131702 0.9689739318350238 1.402057506218142 0.7736012700308036 0.10003387453546626 0.17458498655819427 1.0536294028960003 0.058308110074219904 0.033955531297156956 4.64282310598344e-08 7.33321786286813 0.4330835743831182 NST(ph)ELAPPLPVR ddPTM_A459_Selumetinib_30min_R2 1 NSTELAPPLPVR 12 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 NS(0.046)T(0.954)ELAPPLPVR 149.32 0.0013544 4917300.0 15411.0 8931.1 14467.0 17706.0 14783.0 13047.0 17859.0 13891.0 11755.0 14523.0 True False 14554.518315120966 9616.086651987269 13536.20897047863 15294.41225544634 12925.827378303195 14844.105821126126 18689.478886937155 13931.420510221158 14106.328462142408 14103.683254714391 1.0319657675420266 0.6818138551695658 0.9597641074329947 1.0844268110129265 0.9164859380958177 1.0524985248916616 1.3251487961976092 0.9877859746718538 1.0001875543700354 1.0 13.783784359151145 -5.516918809755376 7.664168241973049 1.05517132076481 0.8476238963971445 0.2709906343239544 0.1284856746334707 0.15159241530009765 66.0592308031777 0.03464882670087334 0.06529918489458841 3.041453564510137e-06 5.516918809755376 -0.20754742436766538 NST(ph)ELAPPLPVRR ddPTM_A459_Selumetinib_30min_R1 1 NSTELAPPLPVRR 13 1 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 NS(0.334)T(0.666)ELAPPLPVRR 122.96 0.0031780000000000003 7696200.0 1729.5 1851.9 2374.3 2918.3 2188.3 2021.1 1745.2 1894.2 1325.4 1582.1 True False 1769.7939849788195 1635.0786870750464 2051.883101096349 2408.67368827561 1990.3686513757448 2000.7695690119745 1613.558158931419 1843.9596627712597 2249.106996614059 1785.1779459590202 0.9913823935507245 0.9159191613229691 1.1493997591338445 1.349262516786045 1.1149413176883571 1.1207675814845088 0.9038640448051217 1.0329276512435634 1.2598783228894361 1.0 10.801852173458327 -5.262858767293759 24.978607066851374 1.1183888128030983 0.9536507698720397 0.22661232115512997 0.12020354603065989 184.0078288380956 3238262.751246288 0.033479919589052234 0.07633988949412426 5.459353705860502e-06 5.262858767293759 -0.16473804293105865 NST(ph)PPSLAR ddPTM_A459_Selumetinib_30min_R2 1 NSTPPSLAR 9 0 H0YAP0;Q96GY0 H0YAP0 ZC2HC1A Zinc finger C2HC domain-containing protein 1A 1 NS(0.006)T(0.957)PPS(0.037)LAR 111.52 0.023907 9571200.0 60771.0 65698.0 81698.0 62798.0 60910.0 52856.0 52383.0 47865.0 34859.0 70484.0 True False 57393.591105587926 70736.82534763448 76441.63962605674 54244.80406740765 53257.941257691105 60136.43422100425 54818.91329494534 48004.27922552265 41831.77404183941 68448.94378057502 0.8384876074870206 1.0334246438395553 1.1167687243079119 0.7924856260937903 0.7780681237159581 0.8785589798694635 0.8008730342235358 0.7013151200610006 0.6111383424109279 1.0 16.06274065931921 -5.787237015310722 22.194226360774703 0.785255168990959 0.9999465071477056 0.38837067994330354 0.11548532249194471 58.94079384655709 50707.521415371426 0.0328005444523798 0.04868723037789127 1.632160956338939e-06 5.787237015310722 0.21469133815674657 NST(ph)PSSSSSLQK ddPTM_A459_Selumetinib_30min_R1 2 NSTPSSSSSLQK 12 0 Q9P0U3;Q9P0U3-2;F8VRZ8 Q9P0U3 SENP1 Sentrin-specific protease 1 1 NS(0.015)T(0.378)PS(0.378)S(0.161)S(0.049)S(0.015)S(0.005)LQK;NS(0.006)T(0.867)PS(0.024)S(0.024)S(0.024)S(0.046)S(0.008)LQK 120.6 0.0093345 9778600.0 4168.7 4423.5 5436.3 5940.0 4180.799999999999 4515.6 4579.1 4547.3 2422.38 3979.7 True False 4265.8225991218305 3905.5945635706407 4698.080319458398 4902.690507609609 3802.6473781801924 4470.1771638367545 4233.694800345439 4426.690832287907 4110.601936364848 4490.533260560718 0.9499590252648905 0.8697395914807147 1.0462188000522157 1.0917835862989302 0.8468142105923002 0.9954668865493668 0.9428044632313427 0.9857828848895244 0.9153928270540348 1.0 12.132671062965859 -6.265853922952213 24.99635905045705 0.9491419108160714 0.9849329537947277 0.07932743521711527 0.06884107438481639 1303.6646132399596 7381682.229471219 0.021933014691380103 0.02574321887948806 5.421832256833754e-07 6.265853922952213 0.03579104297865632 NSTDLDSAPEDPT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 NSTDLDSAPEDPTSPK 16 0 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 NSTDLDSAPEDPT(0.992)S(0.008)PK;NSTDLDSAPEDPT(0.912)S(0.088)PK 205.66 2.3194e-07 12375900.0 11012.6 12546.5 13042.0 12754.5 8491.900000000001 7088.2 4078.5 3222.4 2098.38 10329.5 True False 11269.172153210611 11077.549947290396 11270.968034578016 10527.166006617299 7723.809144366715 7016.899143570663 3770.855461380812 3136.931484169628 3560.797600388571 11655.391942850454 0.9668634232522095 0.9504227744211972 0.9670175048460513 0.9032013730842212 0.6626812021627968 0.6020303030542792 0.3235288422620482 0.2691399396563285 0.3055064658355658 1.0 13.508709899202769 -6.540098182990705 1.5076609712844438 0.4221999661399451 0.9638390577433559 0.5236985005136724 0.1988599772875928 0.27237097776864777 1.2688259003275262 0.07802906398753008 0.08495800463978806 2.8833795702918637e-07 6.540098182990705 0.5416390916034108 NSTDLDSAPEDPTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 NSTDLDSAPEDPTSPK 16 0 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 NSTDLDSAPEDPT(0.125)S(0.875)PK 88.95100000000002 0.027615 0.0 15134.0 13070.0 12524.0 10300.0 11981.0 9240.6 6458.7 5553.7 4847.2 4509.5 True False 14292.912866202098 14072.426973326206 11718.219475100188 8897.122231508947 10475.839668501016 10513.408772185021 6759.0423476712585 5569.860347535474 5816.775442083936 4379.2990179119 3.26374445036574 3.213397147755419 2.6758208167953716 2.031631591064818 2.3921270563287584 2.4007058502248464 1.5434073626911295 1.2718611642534625 1.3282434970283077 1.0 12.096484244827307 -5.768898583510131 0.28429733598923673 0.8313227042037881 4.380838265067011 0.9018327630665401 0.2407795140084579 1.5006682758995151 0.15763780996369434 0.3581756559488807 1.7968540469369179 1.7025560430305846e-06 5.768898583510131 3.549515560863223 up NSTGGTSVGWDS(ph)PPASPLQR ddPTM_A459_Selumetinib_30min_R1 2 NSTGGTSVGWDSPPASPLQR 20 0 Q13424-2;Q13424 Q13424-2 SNTA1 Alpha-1-syntrophin 1 NSTGGTSVGWDS(1)PPASPLQR;NSTGGT(0.001)S(0.001)VGWDS(0.998)PPASPLQR 283.64 3.102099999999999e-72 17558200.0 1013.1700000000001 998.8299999999999 1305.46 1481.09 1110.98 1393.88 1195.81 832.15 517.88 712.8299999999999 True False 1036.7748897143633 881.8865192565302 1128.1857023784855 1222.4454350026122 1010.4920551594503 1379.8588327417795 1105.609088947846 810.078678795853 878.8045355413376 804.3286740521887 1.2889940681725496 1.096425562964959 1.4026426494218003 1.519833215498785 1.2563173336449829 1.7155410185615831 1.3745737589806586 1.0071488247642544 1.0925938162989282 1.0 9.65164134233595 -7.757446117358749 24.35426685419764 1.0374034227516038 1.3828363114801434 0.5091714330225363 0.15560399125993876 62.62205378543498 381932.50076721644 0.08100248328312636 0.044509750037429976 1.7480501284367975e-08 7.757446117358749 0.3454328887285396 NSTGGTSVGWDS(ph)PPASPLQR ddPTM_A459_Selumetinib_30min_R2 1 NSTGGTSVGWDSPPASPLQR 20 0 Q13424-2;Q13424 Q13424-2 SNTA1 Alpha-1-syntrophin 1 NSTGGT(0.017)S(0.062)VGWDS(0.921)PPASPLQR 128.72 0.0001871 6573200.0 22979.0 17708.0 26376.0 23851.0 30743.0 10949.0 15942.0 22430.0 10321.0 15776.0 True False 21701.91917222534 19066.146659805676 24678.99687601745 20602.45265473007 26880.789494092904 12457.12536487391 16683.33458847371 22495.26758651361 12385.488392834694 15320.505889029419 1.4165275826671933 1.2444854496259425 1.610847386814386 1.3447632084710013 1.7545627859026167 0.8131014377138881 1.0889545494982757 1.4683110172374816 0.8084255495573154 1.0 13.903176315947045 -6.764755078290498 24.99999987487532 1.0683527282631602 1.4618697284824727 0.5031346830259713 0.2164874902499233 82.07265716795538 618813.5146966436 0.07392239376233152 0.06786773243816958 1.7188774801147533e-07 6.764755078290498 0.39351700021931246 NSTLPMEET(ph)SPCSSR ddPTM_A459_Selumetinib_30min_R1 2 NSTLPMEETSPCSSR 15 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 NSTLPMEET(0.499)S(0.499)PCS(0.001)SR;NSTLPMEET(0.499)S(0.499)PCS(0.001)SR 181.69 4.7903e-05 10937300.0 3930.4 4704.0 5313.200000000001 5660.8 4790.1 4794.8 4747.8 4277.4 2675.62 4151.9 True False 4021.9706727729135 4153.253493169726 4591.6966233185 4672.247546376511 4356.836300760845 4746.568665330072 4389.66962352429 4163.949457046663 4540.331720447043 4684.836807930762 0.8585081695832584 0.8865310924254308 0.9801187984916383 0.9973127641217002 0.9299867806249603 1.0131769493645555 0.9369952046340662 0.8888141951919626 0.969154723332285 1.0 12.19378307843992 -5.1390310134549315 4.311614300117202 0.9610329592893636 0.864808149622825 0.5152892884103055 0.03588094091051576 0.1865074327984029 5.562799019027051 0.009572051718211736 0.028638368332766936 7.260541072475782e-06 5.1390310134549315 -0.09622480966653857 NSTLPMEETS(ph)PCSSR ddPTM_A459_Selumetinib_30min_R1 1 NSTLPMEETSPCSSR 15 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 NSTLPMEET(0.08)S(0.92)PCSSR 185.86 2.1768e-05 7615600.0 1311.7 1752.4 1666.5 1994.6 1526.2 1296.6 1496.0 1447.8 760.09 1272.7 True False 1342.2600578761019 1547.2281933313418 1440.1984534292478 1646.2805532791451 1388.1554794724943 1283.557381218606 1383.1555155634908 1409.3996408828164 1289.8172152228615 1436.063442147806 0.9346801948168739 1.0774093594481282 1.0028794071070128 1.14638427868962 0.966639382864827 0.8938026994816407 0.963157667668787 0.9814327135679252 0.8981617227814005 1.0 10.487903770348293 -6.500787616180973 24.856002260010495 0.9452609306547649 1.0423357684815997 0.3613567978635501 0.05890171303046112 727.6014500021953 818667.225618856 0.017561779014955422 0.019742346407312168 3.156547898338613e-07 6.500787616180973 0.09707483782683479 NSTLPMEETS(ph)PCSSR ddPTM_A459_Selumetinib_30min_R2 2 NSTLPMEETSPCSSR 15 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 NSTLPMEET(0.219)S(0.737)PCS(0.037)S(0.007)R;NSTLPMEET(0.028)S(0.835)PCS(0.122)S(0.015)R 201.75 1.4827e-05 26137000.0 94331.0 85970.0 84171.0 96867.0 106444.0 77971.0 88604.0 78299.0 66300.0 86751.0 True False 89088.46065691228 92563.62256288105 78755.52949845546 83673.54749510463 93071.55309856634 88710.79749973369 92724.2615654952 78526.83712690268 79561.8525767794 84246.273223833 1.0574765772749866 1.0987266144930798 0.9348250846563949 0.9932017677837606 1.1047557302776532 1.0529937302275547 1.1006333932319725 0.932110515064157 0.9443961083642524 1.0 16.362325247204012 -7.774092446582346 24.999537128500265 0.9536899585506551 1.046628526510264 0.38353564194528567 0.0521716538628882 256.50715038275496 506790.89088321076 0.029894141066215688 0.014509605687250713 1.6823159148877584e-08 7.774092446582346 0.09293856795960886 NSTS(ph)SIEPR ddPTM_A459_Selumetinib_30min_R1 1 NSTSSIEPR 9 0 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;O95819-2;O95819-6 G5E948;O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 NS(0.013)T(0.007)S(0.582)S(0.399)IEPR 89.35600000000002 0.029977 5281200.0 2196.0 2788.7 2443.2 2326.7 2135.2 2209.4 2016.8 2016.0 1287.0 1860.2 True False 2247.1625273278346 2462.197707568543 2111.4268595369576 1920.385522568229 1942.0715370001772 2187.175441974696 1864.6711522650053 1962.5291311091012 2183.9450012390935 2098.974789882415 1.0706000558747641 1.173047775245779 1.0059324531740756 0.9149159541243511 0.9252476715592056 1.0420208248890983 0.8883723431330325 0.9349941412202681 1.0404817684167798 1.0 11.035469123645639 -5.431654422350321 4.863207383420617 0.9594573993610764 1.1196939505540573 0.5688789856718846 0.054097223030719684 0.14337752507757826 5.588753663982573 0.014026842339404703 0.029956804289743656 3.7012257729240402e-06 5.431654422350321 0.16023655119298086 NSVHEQEAINS(ph)DPELSNCENFQK ddPTM_A459_Selumetinib_30min_R2 2 NSVHEQEAINSDPELSNCENFQK 23 0 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 NSVHEQEAINS(1)DPELSNCENFQK;NSVHEQEAINS(0.999)DPELS(0.001)NCENFQK 202.11 3.1588e-23 37162000.0 61541.0 61152.0 89023.0 120288.0 125272.0 76768.0 72669.0 86408.0 78254.0 116117.0 True False 58120.797588142224 65842.16176532858 83295.35710091364 103904.56689162621 109534.21141411073 87342.09516948034 76048.2524908918 86659.43297438558 93906.98659944625 112764.40050180198 0.515417962845583 0.5838913830280721 0.7386671390106186 0.9214305794138089 0.971354531453926 0.7745538022709978 0.674399474944901 0.7684999218614278 0.8327715678135992 1.0 16.78295215808081 -5.31652391896725 2.6997482394093613 0.8338314542193526 0.5323109127292472 0.608878446831115 0.09469179127783298 0.20813060325746988 2.9294674604665567 0.028096750780049647 0.08069139559623748 4.824764067191481e-06 5.31652391896725 -0.3015205414901053 NSVTPLAS(ph)PEPTK ddPTM_A459_Selumetinib_30min_R2 2 NSVTPLASPEPTK 13 0 Q5W015;Q5VX20;A0A1W2PR17;Q16875-3;Q16875-2;Q16875;Q16875-4;Q9H178 Q5W015 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 NSVT(0.001)PLAS(0.997)PEPT(0.002)K;NSVT(0.012)PLAS(0.926)PEPT(0.062)K 153.92 0.00039855 18361400.0 176412.0 153963.0 152075.0 176295.0 158379.0 131007.0 174144.0 149353.0 125359.0 144502.0 True False 166607.7272731894 165771.4670309272 142290.6600667409 152283.31687416226 138482.0140937756 149052.0250868607 182242.0410597894 149787.59250327983 150434.30282311424 140329.8517987149 1.187257915102531 1.1812986681458555 1.0139728521258509 1.085181199311698 0.9868321837352911 1.0621547958352913 1.2986690908873197 1.067396498915504 1.0720050003251829 1.0 17.098462414691163 NSVTPLAS(ph)PEPTKKPR ddPTM_A459_Selumetinib_30min_R2 1 NSVTPLASPEPTKKPR 16 2 Q5W015;Q5VX20;A0A1W2PR17;Q16875-3;Q16875-2;Q16875;Q16875-4;Q9H178 Q5W015 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 NSVT(0.002)PLAS(0.997)PEPT(0.001)KKPR 69.612 0.017515 7718700.0 62120.0 71466.0 51699.0 73783.0 60375.0 33996.0 36059.0 33055.0 30547.0 63678.0 True False 58667.61908606282 76947.21240059155 48372.74262561516 63733.62811722559 52790.15274065182 38678.64041503819 37735.81494955297 33151.18457745015 36657.25355449289 61839.45068468656 0.9487086065043396 1.2443062082316678 0.7822311176770173 1.030630566920739 0.8536646454028797 0.6254686933145134 0.610222350485684 0.5360847195503865 0.5927810345762079 1.0 15.916239883514693 -6.571412965508492 2.7425637959972176 0.6383880242787404 1.0034673859776597 0.4763545408608777 0.16017559720709115 0.21285332323685496 3.2535583231203864 0.05438130343251752 0.05633804597845158 2.682792196892308e-07 6.571412965508492 0.3650793616989193 NSYATTENKT(ph)LPR ddPTM_A459_Selumetinib_30min_R1 2 NSYATTENKTLPR 13 1 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L0Y9 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 NSYAT(0.05)T(0.002)ENKT(0.947)LPR;NSYATTENKT(1)LPR 159.41 0.00035104 39017000.0 9729.7 8964.2 10984.7 11106.0 7623.0 9581.6 8803.7 8606.2 7211.0 7991.299999999999 True False 9956.383079299469 7914.667296656482 9493.038074638021 9166.545585439782 6933.500995949958 9485.21780339673 8139.629821100469 8377.935619122594 12236.540329397907 9017.061196853749 1.104171621101282 0.8777435490199494 1.0527862534580947 1.0165779498799667 0.7689313452113655 1.0519189785144556 0.9026920904053046 0.9291204125403785 1.357043061176906 1.0 13.138441597570829 -8.232844254093951 24.98785561044789 1.1785216222481896 0.9594158767987844 0.32762020581236495 0.1234206654234024 647.959439393926 566221.299298031 0.07750693411323793 0.02928302685655963 5.849998381212973e-09 8.232844254093951 -0.2191057454494052 NSYATTENKT(ph)LPR ddPTM_A459_Selumetinib_30min_R2 2 NSYATTENKTLPR 13 1 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L0Y9 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 NSYAT(0.001)TENKT(0.999)LPR;NSYATTENKT(1)LPR 130.47 0.016803 15088800.0 74963.0 63880.0 50195.0 56048.0 50331.0 50748.0 50495.0 42857.0 32265.0 62717.0 True False 70796.85656066526 68779.39059342595 46965.508348183794 48414.1657118071 44007.9698151511 57738.07635552297 52843.1175539443 42981.706774641694 38718.90155942363 60906.197251664424 1.1623916736770254 1.129267524439746 0.7711121440421292 0.794897200883512 0.7225532343336123 0.9479836036544725 0.8676147902584777 0.7057033391370876 0.6357136598011056 1.0 15.894301410462079 -5.25500968289615 17.457675832039854 0.7991242656170711 1.1458344003612366 0.6271408926302228 0.10480738947507226 5.03318379470088 13656.012035621336 0.027209427968073612 0.06705233704533134 5.558918631382862e-06 5.25500968289615 0.34671013474416557 NSYNNSQAPS(ph)PGLGS(ph)KAVGMPS(ph)PVSPK ddPTM_A459_Selumetinib_30min_R1 1 NSYNNSQAPSPGLGSKAVGMPSPVSPK 27 1 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 3 NS(0.11)Y(0.092)NNS(0.097)QAPS(0.703)PGLGS(0.987)KAVGMPS(0.505)PVS(0.505)PK 49.593 0.042886 0.0 353.43 475.13 640.65 731.31 595.01 414.16 534.96 499.4 285.77 392.08 True False 361.6642313449345 419.50155871805583 553.6532488385521 603.6004368888861 541.1914505575477 409.99392642719283 494.60753650123314 486.15428972018157 484.93081818500053 442.4072871826132 0.817491578061755 0.9482247939213928 1.251455988359477 1.3643546441850016 1.2232878305509447 0.9267341165154881 1.11799138674014 1.0988840007952014 1.0961185139449 1.0 8.7892313391259 -5.049049787348956 4.493353394042289 1.1410552464880417 0.8399771961238374 0.4370688107872023 0.11834895681915708 0.1852232207722334 8.055528857372412 0.03333467687885066 0.10832055097351377 8.932030814130326e-06 5.049049787348956 -0.3010780503642043 NSYNNSQAPS(ph)PGLGSK ddPTM_A459_Selumetinib_30min_R1 2 NSYNNSQAPSPGLGSK 16 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 NSYNNS(0.06)QAPS(0.933)PGLGS(0.006)K;NS(0.006)Y(0.111)NNS(0.051)QAPS(0.829)PGLGS(0.003)K 146.28 0.00035102 21213000.0 8540.2 8924.3 10717.3 10632.3 8395.7 8592.0 9068.2 8047.2 5018.0 7785.6 True False 8739.170043663562 7879.438807205485 9261.949525914963 8775.5683979895 7636.310417381226 8505.57228091182 8384.178373150298 7833.762115010498 8515.17949978071 8784.95759816608 0.9947879595330003 0.8969239429055835 1.0542964405256159 0.9989312184980221 0.8692484092325452 0.9681973061187473 0.9543789232290151 0.8917245219994971 0.9692909048938736 1.0 13.100819607541936 NSYNNSQAPS(ph)PGLGSK ddPTM_A459_Selumetinib_30min_R2 2 NSYNNSQAPSPGLGSK 16 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 NSYNNS(0.002)QAPS(0.998)PGLGSK;NSYNNSQAPS(1)PGLGSK 217.67 1.2232e-10 62872000.0 198031.0 188107.0 194860.0 231551.0 201900.0 160913.0 187274.0 174589.0 116915.0 179318.0 True False 187025.2298009033 202534.20204066343 182322.91974752673 200013.35435224551 176535.51699109873 183077.30512722218 195982.612076391 175097.0250852352 140301.2668780416 174140.62341588328 1.073989664974662 1.1630497127426178 1.0469867178096777 1.1485737815154875 1.013752641561963 1.051318764892648 1.125427302556191 1.0054921226913713 0.8056779867094745 1.0 17.40989326768534 -8.013666517827083 5.677771762442698 0.9016880762581969 1.0871879175834638 0.5905824535548454 0.0619799082125069 0.10509942228862929 11.76806864253188 0.037302839701861934 0.015255164658793589 9.690216543585871e-09 8.013666517827083 0.18549984132526687 NSYNNSQAPSPGLGS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 NSYNNSQAPSPGLGSK 16 0 Q9UHB7 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 NSYNNS(0.001)QAPS(0.426)PGLGS(0.573)K 207.92 6.7137e-08 10934000.0 2939.5 3343.2 3516.1 3658.6 2851.8 3216.6 2931.5 2933.9 2063.5 2697.0 True False 3007.984630728674 2951.7765897884847 3038.632932554802 3019.694190427696 2593.855193526185 3184.2439244391257 2710.374594835809 2856.0834413497 3501.6087879229767 3043.186221004664 0.9884326532392196 0.9699625246114575 0.9985037759377214 0.9922804492164097 0.8523484943586072 1.0463519788768936 0.890637114524335 0.938517472784431 1.1506390124121195 1.0 11.571366903726473 -8.243535343923524 24.72836595695711 1.0753195191445692 0.9593729200203549 0.35389461598512273 0.06252675025338733 637.796692437221 880903.5570661313 0.04024729923736558 0.015142548838921471 5.707746232778569e-09 8.243535343923524 -0.11594659912421434 NSYVAGQYDDAASYQR ddPTM_A459_Selumetinib_30min_R1 2 NSYVAGQYDDAASYQR 16 0 P11413-3;P11413;P11413-2;E7EUI8;E9PD92;E7EM57 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 ; 247.11 4.3314999999999985e-28 23692900.0 2061.69 2218.33 2429.9 2902.07 2049.45 2336.7200000000003 2457.41 2093.21 1366.8000000000002 1930.8799999999999 False True 2109.723365649599 1958.6068923263622 2099.9329264852868 2395.277953100778 1864.0776093597858 2313.214718372005 2272.045585227858 2037.6912710956767 2319.3597728776954 2178.7272563639167 0.9683283483452269 0.898968370917196 0.9638346976894528 1.099393210464656 0.8555809837669859 1.0617275345572785 1.042831579120959 0.935266800901176 1.0645480135721443 1.0 11.089269888862846 -5.528055734215235 24.997266882022505 1.0052568909950166 0.9330866361669841 0.16667896650928538 0.0683469339119349 226.40139744329727 1093184.0552620015 0.017723384169838628 0.03082847328010592 2.9644509289034462e-06 5.528055734215235 -0.07217025482803252 NSYVAGQYDDAASYQR ddPTM_A459_Selumetinib_30min_R2 2 NSYVAGQYDDAASYQR 16 0 P11413-3;P11413;P11413-2;E7EUI8;E9PD92;E7EM57 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 ; 280.5 1.9247999999999992e-61 25409000.0 48867.0 46837.0 48168.0 58896.0 55435.0 40966.0 42449.0 51190.0 37319.0 49406.0 False True 46151.16777010033 50429.24729530827 45068.923321353046 50874.26319873308 48470.75970481214 46608.69464767781 44422.96261109776 51338.954425039294 44783.842779982326 47979.52040779587 0.9618930614112919 1.051057761034109 0.9393366781971856 1.0603328829953638 1.010238520369546 0.9714289399213061 0.9258734191907382 1.0700180824795733 0.9333949651715506 1.0 15.550131116406462 -6.752913590266369 24.79668399857749 0.9811273574442309 1.0066280055489794 0.0552141507603886 0.05008369739712427 554.6489166984702 1613158.332333892 0.01590697586634558 0.015657230321807093 1.7663892367100998e-07 6.752913590266369 0.025500648104748502 NT(ph)FTAWSDEESDYEIDDR ddPTM_A459_Selumetinib_30min_R2 1 NTFTAWSDEESDYEIDDR 18 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 NT(0.512)FT(0.028)AWS(0.46)DEESDYEIDDR 180.78 2.9555e-09 2704500.0 4234.2 4050.6 5172.0 4911.2 5429.3 3339.4 4967.2 5691.8 5550.9 4501.8 True False 3998.8801148455746 4361.267995268177 4839.239150847826 4242.286087707446 4747.222795442164 3799.3720379450115 5198.184642320074 5708.362195671786 6661.2351051047435 4371.821336918906 0.914694313117524 0.9975860537662854 1.1069160374834388 0.9703704156165834 1.0858684355083519 0.8690593107866262 1.1890203742826229 1.305717172718413 1.5236750525123997 1.0 12.094018728305054 -7.490129707915129 4.370691027345102 1.3040968672929498 0.9999786052287912 0.4771062828109568 0.1362103465677853 0.16525030584530712 7.295898950886428 0.059754689191599396 0.036929069532383285 3.234970257424705e-08 7.490129707915129 -0.3041182620641586 NTAAEEHVAQGDATLEHSTNLDS(ph)SPSLSSVTVVPLR ddPTM_A459_Selumetinib_30min_R2 1 NTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLR 36 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 NTAAEEHVAQGDATLEHS(0.004)T(0.004)NLDS(0.704)S(0.23)PS(0.046)LS(0.01)S(0.002)VT(0.001)VVPLR 86.23299999999998 2.0911e-09 4310100.0 10421.0 10168.0 15435.0 20911.0 18200.0 12778.0 12241.0 13631.0 12225.0 15789.0 True False 9841.842538568264 10947.852904726913 14441.928904357339 18062.88572651295 15913.553289935622 14538.053512864997 12810.230755081335 13670.663953266474 14670.341595039637 15333.13054525136 0.6418677848938201 0.7139998496991498 0.9418773851651563 1.178029866321525 1.0378541578949785 0.9481464642826903 0.83546088108202 0.8915768318101388 0.9567740620054274 1.0 13.904364659783063 -5.234672318812606 3.776882887282763 0.9752758791476472 0.6622245329641708 0.6578931844862442 0.08614996996305553 0.15046020351234168 4.733649204760929 0.026035155626778637 0.07316281893188038 5.825425884265731e-06 5.234672318812606 -0.3130513461834764 NTAAEEHVAQGDATLEHSTNLDSS(ph)PSLSSVTVVPLR ddPTM_A459_Selumetinib_30min_R1 2 NTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLR 36 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 NTAAEEHVAQGDATLEHS(0.001)T(0.001)NLDS(0.262)S(0.64)PS(0.076)LS(0.013)S(0.006)VT(0.001)VVPLR;NTAAEEHVAQGDATLEHSTNLDS(0.227)S(0.717)PS(0.049)LS(0.005)S(0.002)VTVVPLR 160.43 1.8891e-39 19204300.0 2536.6 2753.9 2448.8 3268.3 3429.8999999999996 2650.1 3325.6 3007.4 601.65 1745.4700000000003 True False 2595.6978446356015 2431.472107746625 2116.266410295554 2697.552758589307 3119.6661505980283 2623.4424000982794 3074.74731454408 2927.6339825880536 1020.956107222611 1969.5180768175783 1.3179355270654982 1.234551810601043 1.0745097672396575 1.3696511803273796 1.5839743678001181 1.3320225038692393 1.5611673488736761 1.4864722578828193 0.5183786425927659 1.0 10.943626943155243 -10.510742911670249 11.226500012458459 0.999999977224138 1.2964217486867153 0.06997868920893591 0.2923033758614409 0.0 0.0 0.28028341394605205 0.067978712988723 3.085013638421514e-11 10.510742911670249 0.2964217714625773 NTADHDES(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 NTADHDESPPR 11 0 O95251;O95251-4 O95251 KAT7 Histone acetyltransferase KAT7 1 NT(0.001)ADHDES(0.999)PPR;NTADHDES(1)PPR 128.22 0.0028173 3897500.0 14752.800000000001 10447.7 11993.2 12539.300000000001 14584.7 11982.9 15801.5 18822.7 15978.699999999999 12335.2 True False 13932.898436137597 11249.00499534967 11221.570569208847 10831.42570850098 12752.439597127692 13633.435705064163 16536.30106007824 18877.47094073427 19174.886482180762 11979.050725301451 1.1631053875337003 0.9390564622612523 0.9367662619131666 0.9041973322329686 1.064561782862538 1.1381065175947886 1.380435014366475 1.575873695973453 1.6007016684285915 1.0 13.548225966460633 -7.117394842388153 2.082258817111218 1.4477634183499295 0.9869290888050869 0.5303259334490774 0.16981549291995343 0.22365976971438817 1.9088636207899918 0.07624173259738393 0.05463702138783388 7.631416515995572e-08 7.117394842388153 -0.4608343295448426 NTADHDES(ph)PPRT(ph)PTGNAPSSESDIDISSPNVSHDESIAK ddPTM_A459_Selumetinib_30min_R2 1 NTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAK 39 1 O95251;O95251-4 O95251 KAT7 Histone acetyltransferase KAT7 2 NT(0.001)ADHDES(0.896)PPRT(0.66)PT(0.268)GNAPS(0.058)S(0.058)ES(0.058)DIDIS(0.001)SPNVSHDESIAK 92.188 3.6395e-10 4302600.0 26222.0 25834.0 27342.0 29505.0 28216.0 21959.0 23836.0 25679.0 21592.0 30051.0 True False 24764.68621498294 27815.38473059749 25582.845487718725 25486.368101036045 24671.25382575953 24983.65292604496 24944.421230137967 25753.72163861271 25911.00333088718 29183.3495481252 0.8485895758519562 0.953125160795136 0.8766247152517906 0.8733188100635056 0.8453880108955644 0.856092714266583 0.8547483964787191 0.8824799770205674 0.8878694095123758 1.0 14.832857859074561 -10.814071998369764 4.242603284904449 1.0001221824903654 0.8757790616214502 0.6171389696818985 0.029449942365083418 3.538769291357352e-05 5.912150430670822e-06 0.029647945766869566 0.007183627618453954 1.5343625914417184e-11 10.814071998369764 -0.12434312086891519 NTADHDES(ph)PPRTPTGNAPS(ph)SESDIDISSPNVSHDESIAK ddPTM_A459_Selumetinib_30min_R2 1 NTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAK 39 1 O95251;O95251-4 O95251 KAT7 Histone acetyltransferase KAT7 2 NT(0.13)ADHDES(0.298)PPRT(0.298)PT(0.298)GNAPS(0.318)S(0.318)ES(0.318)DIDIS(0.019)S(0.005)PNVSHDESIAK 61.608 5.2863e-05 3652200.0 7754.7 7027.4 11727.0 9083.3 9837.2 8554.0 7947.3 9965.1 7780.8 9539.3 True False 7323.724818523683 7566.378983347549 10972.497587392192 7846.138870433509 8601.362990316195 9732.235854519266 8316.865197276193 9994.096791188887 9337.177413716512 9263.875622922056 0.7905681290023191 0.8167617195362264 1.1844392168049418 0.8469607311025881 0.9284842910707292 1.0505576985984486 0.8977738406480081 1.0788245868133213 1.0079126484182368 1.0 13.177400168451443 -5.039115124940564 24.35669983720956 0.9929554166762379 0.7971163662638883 0.42697040557889154 0.09066659472459687 304.8618804904965 189835.54662224953 0.022225546717868055 0.05883186327637603 9.138709559018032e-06 5.039115124940564 -0.1958390504123496 NTAPS(ph)PGPSVIR ddPTM_A459_Selumetinib_30min_R1 1 NTAPSPGPSVIR 12 0 Q9H7P9;E7ESZ3;Q9H7P9-2;M0QX05 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 NT(0.006)APS(0.982)PGPS(0.012)VIR 132.65 0.0018539 5593200.0 2272.4 2181.9 2365.9 2573.8 2384.9 2222.3 2481.8 1913.9 1328.0 1852.6 True False 2325.342498679313 1926.4421336622095 2044.6237749584498 2124.3341462096982 2169.186216088294 2199.9456796869567 2294.595827891358 1863.1371547766414 2253.519006717575 2090.3992558521454 1.112391564515456 0.921566599427869 0.9781020392321966 1.0162336884987644 1.0376899102004469 1.0524045459393139 1.097683048569577 0.8912829209830248 1.078032820959331 1.0 11.029562800856974 -4.716066535681836 23.91713056295948 1.0091369769403713 1.1123940387201594 0.2049500226403791 0.06158698248845636 12160.49406677473 6409234.495193444 0.015174316513523946 8.713167382680744 1.922797125999702e-05 4.716066535681836 0.1032570617797881 NTAPS(ph)PGPSVIR ddPTM_A459_Selumetinib_30min_R2 2 NTAPSPGPSVIR 12 0 Q9H7P9;E7ESZ3;Q9H7P9-2;M0QX05 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 NTAPS(0.999)PGPS(0.001)VIR;NT(0.001)APS(0.999)PGPSVIR 148.18 0.00060978 46512000.0 217503.0 179477.0 191623.0 202568.0 243020.0 145414.0 187828.0 196218.0 126225.0 174666.0 True False 205415.05399349504 193242.30879048718 179294.1848033478 174977.88895070922 212489.65497363455 165443.45856313573 196562.3741741211 196788.96189436121 151473.52702117583 169622.93874323094 1.2110098758779606 1.1392463202339065 1.057016144937548 1.031569728995112 1.2527176839878578 0.975360171147477 1.1588195301324786 1.1601553619599363 0.8930014309589988 1.0 17.371971758567383 -1.5228787452803396 0.06774025430008862 0.8574829271591871 1.6272900683485512 0.21590715898732138 0.0960713000796431 476.3391818782374 2.3985574104395204 4.928595272604738 35.199837458985904 0.029999999999999857 1.5228787452803396 0.7698071411893641 NTASQNSILEEGET(ph)K ddPTM_A459_Selumetinib_30min_R2 1 NTASQNSILEEGETK 15 0 Q15398-1;Q15398;Q15398-3 Q15398-1 DLGAP5 Disks large-associated protein 5 1 NTAS(0.001)QNS(0.027)ILEEGET(0.972)K 106.6 0.010394 4029800.0 12842.0 10734.0 11330.0 9983.7 10895.0 11215.0 14179.0 11145.0 11276.0 12300.0 True False 12128.293050599144 11557.263284750068 10601.04013517128 8623.902837156873 9526.272697464205 12759.764450366327 14838.351595155484 11177.43010484593 13531.515077764161 11944.867040762036 1.0153560528728502 0.9675506010498682 0.8874975417470177 0.7219756241511669 0.7975201954911393 1.0682215554868415 1.2422366481367595 0.9357517389438311 1.1328309500296374 1.0 13.544103174683098 -6.80556519271715 9.684223851150827 1.0825814305812576 0.8748934955228002 0.4602393383061165 0.10697339030013707 0.36580832492727483 76.858718281511 0.0399651843125957 0.03535393210613236 1.5647134196801608e-07 6.80556519271715 -0.2076879350584574 NTDDDRPPRR ddPTM_A459_Selumetinib_30min_R2 2 NTDDDRPPRR 10 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 ; 107.45 0.0071543000000000015 12696200.0 16950.3 13440.8 12360.0 13413.5 12545.2 12556.5 17086.6 26238.0 13401.8 28144.0 False True 16008.270183427097 14471.666141016283 11564.77105655048 11586.558160421868 10969.159820489022 14286.043898441789 17881.160756455592 26314.348236065263 16082.53447757892 27331.409593106226 0.5857096440230748 0.5294884660711556 0.42313116040189347 0.42392830567159384 0.40133897167366595 0.5226969304226864 0.654234853696157 0.9627878191362111 0.5884268216314537 1.0 14.738272247041094 -7.434927185553115 2.7571706301682504 0.8320521264192595 0.4724750908344431 0.6650911373215681 0.11671519635355192 0.1660296293032053 2.459006138418187 0.0561335000465525 0.033385798542312224 3.6734388474730886e-08 7.434927185553115 -0.3595770355848164 NTDEMVELR ddPTM_A459_Selumetinib_30min_R1 1 NTDEMVELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 147.73 0.022267 12462000.0 1930.4 2404.4 2067.6 2367.3 2418.1 2356.2 2170.8 1779.5 1343.6 1896.8 False True 1975.3745640954696 2122.8917302247655 1786.8312765138398 1953.8954947246182 2199.383281950229 2332.498767258431 2007.054808278893 1732.3018793693684 2279.9910673386535 2140.272756396605 0.9229545898725728 0.9918790602179591 0.8348614778997493 0.9129189206772998 1.027618220797775 1.089813791390524 0.9377565556915279 0.8093836984992032 1.065280609924354 1.0 11.063578950085514 -4.388661908408814 10.683182656168144 0.9569387739817549 0.0001756378962453867 0.01420607269099583 0.08743311263750382 584211.4378502466 908231.4375804871 0.022393415917988435 13002284.654062396 4.086373804712076e-05 4.388661908408814 -0.9567631360855094 NTDEMVELR ddPTM_A459_Selumetinib_30min_R2 4 NTDEMVELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;;; 160.75 0.012644 38109200.0 219791.0 221976.0 236410.0 262898.0 271081.0 218000.0 223786.0 209713.0 170045.0 213094.0 False True 207575.8961130849 239000.84543466425 221199.6379837458 227090.83887565436 237025.38128511168 248027.5211930325 234192.4924235463 210323.23011014372 204058.75145427528 206941.4225352961 1.0030659573613425 1.154920278920476 1.0688997653237733 1.0973677289616657 1.1453742724933886 1.1985397517538023 1.1316849452100497 1.0163418591281348 0.9860701108279608 1.0 17.658862926328304 -7.825807318391743 5.097965975085685 0.9968025978590229 1.1178819402674427 0.5196044270175946 0.050090124515061674 0.1658470186346199 8.279082448605005 0.028977801583880188 0.01371394019880138 1.4934568583453287e-08 7.825807318391743 0.12107934240841978 NTDQASMPDNTAAQK ddPTM_A459_Selumetinib_30min_R1 2 NTDQASMPDNTAAQK 15 0 P35579;A0A494C024;P35579-2;P35749-4;P35749-3;P35749;P35749-2 P35579;P35579-2;P35749-4 MYH9;MYH11 Myosin-9;Myosin-11 0 ; 250.81 6.5397e-26 28509000.0 5626.7 6221.4 6955.5 7168.8 6756.8 5573.6 6523.9 5868.200000000001 3204.3999999999996 5367.3 False True 5757.791162347688 5492.995595749609 6010.98130382666 5916.903655042383 6145.648633009933 5517.5346444238985 6031.796970577979 5712.55627340002 5437.632759883879 6056.245236929303 0.950719618690187 0.9069968901283663 0.9925260732794247 0.9769920839669349 1.0147621822735104 0.9110487486172956 0.995963131380109 0.9432504877058868 0.8978554446122331 1.0 12.56420791055019 -6.394794927857752 0.0019646122211815177 1.9155957710802876 1.7256816813132328e-05 0.022238670576787523 0.040364278491523416 657617.9499465863 396.2573745137451 191826.38265220023 194538.38460716943 4.0290724062524636e-07 6.394794927857752 -1.9155785142634745 NTDVAQS(ph)PEAPK ddPTM_A459_Selumetinib_30min_R1 1 NTDVAQSPEAPK 12 0 Q9P2E9;A0A087WVV2;Q9P2E9-3;V9GY78 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 NTDVAQS(1)PEAPK 106.76 0.010074 0.0 4124.0 5297.4 3947.7 3807.3 3585.0 4286.4 4650.0 4424.7 2641.6 5445.8 True False 4220.081176092894 4677.177945305556 3411.6240231639 3142.426526872403 3260.737382983158 4243.282707739809 4299.246756263523 4307.342582548829 4482.6022651695375 6144.821476584056 0.6867703467341191 0.7611576614762172 0.5552031147144804 0.5113942754638492 0.530648025399726 0.6905461328550551 0.6996536470012308 0.700971150905316 0.7294926764351573 1.0 12.585155381738762 -8.935777838954067 0.6508546632164987 1.00573898024882 0.6186583392351865 0.6862298800275397 0.07479525658630413 0.9508328421706693 0.7382884480487685 0.09770686140135179 0.033971452127460784 1.1593702742238808e-09 8.935777838954067 -0.3870806410136334 NTDVAQS(ph)PEAPK ddPTM_A459_Selumetinib_30min_R2 3 NTDVAQSPEAPK 12 0 Q9P2E9;A0A087WVV2;Q9P2E9-3;V9GY78 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 NTDVAQS(1)PEAPK;NTDVAQS(1)PEAPK;NTDVAQS(1)PEAPK 149.35 0.00057855 33445100.0 304820.0 215588.0 260009.0 270486.0 266122.0 233068.0 336143.0 345005.0 246186.0 229715.0 True False 287879.324691141 232122.9063753213 243280.30401639442 233645.3401856242 232689.37519913414 265171.0014193474 351774.31555471866 346008.9074313477 295430.0790115682 223082.53107875198 1.2904610831652912 1.0405248015290713 1.0905394646545061 1.0473493332525592 1.0430640806966225 1.1886677102732777 1.576879703908937 1.551035420649771 1.324308441288378 1.0 17.767218019337612 -7.06153314102404 6.11286583823169 1.4078562304025166 1.096783781149122 0.348076615994809 0.16389540681026354 0.20665654612580048 15.68826451977819 0.06044335259988666 0.04716017410686672 8.678943457235881e-08 7.06153314102404 -0.3110724492533947 NTDVAQS(ph)PEAPKQEAPAK ddPTM_A459_Selumetinib_30min_R1 4 NTDVAQSPEAPKQEAPAK 18 1 Q9P2E9;A0A087WVV2;Q9P2E9-3;V9GY78 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 NT(0.087)DVAQS(0.913)PEAPKQEAPAK;NTDVAQS(1)PEAPKQEAPAK;NTDVAQS(1)PEAPKQEAPAK;NT(0.007)DVAQS(0.993)PEAPKQEAPAK 94.359 0.002346 114306000.0 18451.4 24202.7 30250.199999999997 33422.3 24443.6 22929.5 24645.8 23706.300000000003 11785.599999999999 19748.0 True False 18881.2817198255 21369.036632470034 26142.38899245452 27585.722719272846 22232.680695868086 22698.85004832026 22786.747463552587 23077.531915085165 19999.3024138333 22282.84816180945 0.8473459758248548 0.9589903623314368 1.1732068002536558 1.237980105548266 0.9977486062115101 1.0186691523224485 1.0226137744189618 1.0356634729772887 0.8975200238589824 1.0 14.443646027231965 -8.162534967001667 7.177057923322475 0.949418952937346 1.04328921108334 0.09935930844384022 0.10424515192797822 0.5930842106416162 36.58865137600205 0.07749203325136503 0.028892566243912957 6.878045318436043e-09 8.162534967001667 0.09387025814599403 NTDVAQS(ph)PEAPKQEAPAK ddPTM_A459_Selumetinib_30min_R2 4 NTDVAQSPEAPKQEAPAK 18 1 Q9P2E9;A0A087WVV2;Q9P2E9-3;V9GY78 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 NT(0.003)DVAQS(0.997)PEAPKQEAPAK;NT(0.036)DVAQS(0.964)PEAPKQEAPAK;NT(0.002)DVAQS(0.998)PEAPKQEAPAK;NT(0.002)DVAQS(0.998)PEAPKQEAPAK 77.53 0.007529000000000002 190509000.0 393807.0 324167.0 383612.0 397969.0 345711.0 247429.0 322087.0 317362.0 217999.0 345716.0 True False 371920.7834743261 349029.56653880817 358930.8215651653 343764.9356651821 302279.6934844467 281510.09881316894 337064.68370328256 318285.4708778929 261604.89140098583 335734.2808019583 1.1077831628808656 1.039600620184188 1.0690919637631229 1.023919674940674 0.9003539726786325 0.8384907794960178 1.0039626662435137 0.9480279169515072 0.7792022035286303 1.0 18.356960328177543 -6.131885679896615 3.3992629085849457 0.9099583301274307 1.066946987869796 0.5561877225725451 0.06582485951550032 0.1945546360666932 4.158902311265183 0.02015437646286409 0.02706556858022471 7.380984955299414e-07 6.131885679896615 0.15698865774236526 NTEDLTEEWLR ddPTM_A459_Selumetinib_30min_R2 1 NTEDLTEEWLR 11 0 G3V4P8;P60983 G3V4P8 GMFB Glia maturation factor beta 0 138.76 0.016955 2145100.0 11751.0 9988.1 11368.0 12724.0 13906.0 9933.9 11672.0 11435.0 7998.5 11573.0 False True 11097.926462980111 10754.155153196594 10636.595256542549 10990.96924987571 12159.003958782674 11302.204554034239 12214.77112762923 11468.273956833844 9598.423496762738 11238.857419734883 0.9874603839615134 0.9568726385222065 0.9464125096796058 0.9779436502660944 1.0818718936172336 1.005636439002075 1.0868338899095464 1.0204127989644318 0.8540390840716937 1.0 13.456207753304893 -6.01592337675894 24.01764634040503 1.0145036826400189 0.9627887681683321 0.09672480159439645 0.060625733530597095 903.5458508219393 1362846.2744663027 0.018048783545422546 0.024075334898977358 9.639990884577706e-07 6.01592337675894 -0.051714914471686746 NTEES(ph)SSPVRK ddPTM_A459_Selumetinib_30min_R1 1 NTEESSSPVRK 11 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 NTEES(0.333)S(0.333)S(0.333)PVRK 167.22 0.00098659 151100000.0 6347.9 6986.4 7395.3 7661.7 6358.4 6787.7 5959.7 6140.5 4652.6 5199.5 True False 6495.793719136775 6168.4290401107555 6391.058879475138 6323.727922921302 5783.283842666698 6719.421900738497 5510.155030818004 5977.633992844964 7895.122387540797 5866.906472418892 1.1071923081907586 1.0513937914485874 1.0893405084127992 1.077864109927436 0.9857467252724557 1.1453091901715826 0.9391925807445501 1.018873237701439 1.3457044908857534 1.0 12.518384278059987 NTEESSS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 NTEESSSPVR 10 0 Q5T200;Q5T9K0;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 NTEES(0.016)S(0.113)S(0.872)PVR 112.02 0.0084914 22091000.0 36818.0 34203.0 37086.0 43499.0 42737.0 32589.0 40226.0 47583.0 37496.0 41528.0 True False 34771.80295413169 36826.2601200211 34699.92713618378 37574.36116003957 37367.99598637246 37077.83893651255 42096.58870630682 47721.4586522103 44996.247725775575 40328.978737298035 0.8622039050538409 0.9131463595918569 0.8604216675611412 0.9316963220119712 0.9265792776401965 0.9193845244144829 1.04382977264371 1.1833044164858895 1.1157299077390481 1.0 15.299529251960962 -7.350184999093028 2.9123954309804567 1.112880959005373 0.9011732986474988 0.7793134180003884 0.04826195699918399 0.11297053437282328 1.8619389180841115 0.021950353986658764 0.01396468838456905 4.4649335611328655e-08 7.350184999093028 -0.21170766035787414 NTEESSS(ph)PVRK ddPTM_A459_Selumetinib_30min_R1 4 NTEESSSPVRK 11 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 NTEES(0.184)S(0.184)S(0.632)PVRK;NTEES(0.04)S(0.132)S(0.828)PVRK;NTEES(0.312)S(0.312)S(0.377)PVRK;NTEES(0.074)S(0.074)S(0.852)PVRK 177.81 0.00011243 164267700.0 15009.2 17489.8 18117.7 17968.3 16479.7 17179.5 14140.9 15392.599999999999 11124.1 12493.199999999999 True False 15358.88515718076 15442.086085212566 15657.415853402397 14830.473711764611 14989.114044727352 17006.68982773796 13074.240528096088 14984.338245788667 18876.785227881748 14096.823914073208 1.089528056163602 1.0954301606758634 1.1107052162133637 1.0520436235965878 1.0632972459678205 1.2064199660435397 0.9274600156595381 1.0629584605103446 1.3390807278962027 1.0 13.783082532275285 NTEESSS(ph)PVRK ddPTM_A459_Selumetinib_30min_R2 3 NTEESSSPVRK 11 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 NTEES(0.124)S(0.124)S(0.752)PVRK;NTEES(0.186)S(0.186)S(0.629)PVRK;NT(0.001)EES(0.044)S(0.148)S(0.806)PVRK 137.09 0.0024451 269755800.0 185211.0 161477.0 148130.0 175092.0 184139.0 125813.0 184168.0 195352.0 144899.0 219590.0 True False 174917.714078377 173861.7666696098 138599.47707174974 151244.1675494529 161005.81259645335 143142.598733298 192732.17692196873 195920.44197773552 173882.8488163312 213249.86613666083 0.820247708696245 0.8152960178563056 0.6499393391549821 0.7092345251580524 0.7550101461413019 0.671243557271756 0.9037856877174152 0.9187365297203995 0.815394879098769 1.0 17.7021853103577 -7.2759013487286435 24.176598077206652 0.9027073485505073 0.7360179072525603 0.6217382934731586 0.06588656849253052 375.3088270656446 627414.1089791402 0.027977939021885192 0.018966880294362092 5.297837721697103e-08 7.2759013487286435 -0.16668944129794694 NTENCDFLFS(ph)PPEVTGR ddPTM_A459_Selumetinib_30min_R1 1 NTENCDFLFSPPEVTGR 17 0 A0A494BZT8;Q9Y6A5;E7EMT0;C9JA91;Q8IX09;C9JWI7;F8WC55 A0A494BZT8 TACC3;ERIC-1s Transforming acidic coiled-coil-containing protein 3 1 NTENCDFLFS(1)PPEVTGR 149.95 0.00027808 5586600.0 1070.3 1384.5 1268.8 1417.9 1256.1 1001.7 1670.4 1455.4 699.57 923.3 True False 1095.2359075587349 1222.4020963634118 1096.5039290195198 1170.2903822794053 1142.4859767824664 991.6238074708294 1544.4003831532439 1416.7980641945376 1187.1191954287751 1041.8145487035981 1.051277224839692 1.1733394373159132 1.0524943526503594 1.1233192929928637 1.096630852587095 0.9518237278455897 1.482413914333456 1.3599330763402733 1.139472660375102 1.0 10.024882773912655 -7.24677895346075 24.999460256598674 1.275449355075486 1.0814744883910723 0.2758448053496576 0.13164907723338914 919.7565747616917 1568402.9049651031 0.049101452837518135 0.03786455192731985 5.665275660002125e-08 7.24677895346075 -0.19397486668441366 NTETSKS(ph)PEKDVPMVEK ddPTM_A459_Selumetinib_30min_R1 1 NTETSKSPEKDVPMVEK 17 2 A0A2R8Y611;O14617-3;O14617-2;O14617;O14617-5 A0A2R8Y611 AP3D1 AP-3 complex subunit delta-1 1 NTET(0.013)S(0.044)KS(0.943)PEKDVPMVEK 71.263 0.034023000000000005 89451000.0 3999.2 3853.4 4199.1 4644.2 3103.3 3832.2 3175.6 3161.9 1986.9 3280.6 True False 4092.373578911419 3402.242136602941 3628.8852840052546 3833.177652431069 2822.6070629321166 3793.6515473592017 2936.061935309772 3078.0361407013243 3371.624182565623 3701.696965750054 1.1055398690860163 0.9191033647762585 0.98033018844641 1.0355190302981416 0.7625170534077437 1.0248411964728494 0.7931664753964683 0.8315202916880688 0.9108320356208439 1.0 11.853971080490796 -6.231322212055058 24.99183106584536 0.8809079271808608 1.0014936469640094 0.31117711927783387 0.08897677711589831 858.6125845809994 712494.1107779578 0.025037804794480353 0.032320120816866735 5.8705364368362e-07 6.231322212055058 0.12058571978314869 NTETSKS(ph)PEKDVPMVEK ddPTM_A459_Selumetinib_30min_R2 2 NTETSKSPEKDVPMVEK 17 2 A0A2R8Y611;O14617-3;O14617-2;O14617;O14617-5 A0A2R8Y611 AP3D1 AP-3 complex subunit delta-1 1 NTET(0.017)S(0.054)KS(0.928)PEKDVPMVEK;NT(0.043)ET(0.121)S(0.078)KS(0.757)PEKDVPMVEK 85.57600000000002 0.013168 55359000.0 101870.0 78355.0 74259.0 84488.0 66570.0 57493.0 86155.0 72063.0 49675.0 71579.0 True False 96208.47321792044 84364.57654896518 69481.25678708592 72980.5886500707 58206.881456649084 65412.138880509265 90161.37821289377 72272.69139932806 59611.38803546782 69512.32828542305 1.384049068575015 1.213663513075805 0.9995530073714471 1.0498941763309482 0.8373605501695625 0.941014932084017 1.2970559386629104 1.0397104108291517 0.857565693824825 1.0 16.08498124773012 -4.997776223807155 2.1664682640776123 1.0064227562943844 1.409874581657927 0.5166996625471052 0.11985855121141709 0.37177868894939897 2.773017317915299 0.03458211679026911 0.24629822059561565 1.0051335657375037e-05 4.997776223807155 0.4034518253635426 NTFTAWS(ph)DEESDYEIDDR ddPTM_A459_Selumetinib_30min_R1 1 NTFTAWSDEESDYEIDDR 18 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 NTFT(0.025)AWS(0.973)DEES(0.003)DYEIDDR 257.06 1.979e-42 4625800.0 1110.5 1770.1 819.6 546.97 930.05 1019.9 1370.0 1214.3 476.01 1150.4 True False 1136.3724893431515 1562.8558691028347 708.302821740541 451.4519573985231 845.9271417136641 1009.6407319951078 1266.659797006672 1182.0928193977095 807.7542036051443 1298.0650458449256 0.8754357056147933 1.2039888710550353 0.5456604998399741 0.34778839384328986 0.6516831682830195 0.777804421455568 0.9758061054499688 0.9106576154881911 0.6222755987388657 1.0 10.342146963042804 -7.009434296394607 21.881363637922956 0.8707490648304136 0.7200297135115099 0.08953385313825823 0.22870975129031387 261.8977548994199 607433.2274597774 0.09288730493891445 0.07738410996216001 9.785109806955528e-08 7.009434296394607 -0.15071935131890368 NTFTAWS(ph)DEESDYEIDDRDVNK ddPTM_A459_Selumetinib_30min_R1 5 NTFTAWSDEESDYEIDDRDVNK 22 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 NTFT(0.005)AWS(0.706)DEES(0.053)DY(0.236)EIDDRDVNK;NT(0.027)FT(0.262)AWS(0.708)DEES(0.001)DY(0.001)EIDDRDVNK;NT(0.001)FT(0.038)AWS(0.96)DEESDY(0.001)EIDDRDVNK;NTFT(0.024)AWS(0.975)DEESDYEIDDRDVNK;NT(0.011)FT(0.077)AWS(0.793)DEES(0.022)DY(0.097)EIDDRDVNK 173.74 1.1784e-12 138078200.0 6799.400000000001 7531.009999999999 9336.599999999999 9432.99 7868.5 7103.99 6908.8099999999995 6500.1900000000005 3975.94 5433.91 True False 6957.812790670706 6649.275848128438 8068.741002272738 7785.695375652583 7156.7955642965035 7032.53031050684 6387.672899385155 6327.7838456071795 6746.879788831832 6131.4052792656485 1.134782724965138 1.084461970017551 1.315969281880372 1.2698060266838318 1.1672357703214271 1.1469687600473082 1.0417959029696042 1.0320283128250578 1.1003806601477661 1.0 12.582002053044286 -7.065764052006156 2.2513392325780512 1.0446035097186488 1.1999892844307174 0.545734875619132 0.0650158515634332 0.26889117940149826 2.6978665130101285 0.03121578290147149 0.0234916729319328 8.594803420459043e-08 7.065764052006156 0.1553857747120686 NTFTAWS(ph)DEESDYEIDDRDVNK ddPTM_A459_Selumetinib_30min_R2 5 NTFTAWSDEESDYEIDDRDVNK 22 1 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 NT(0.001)FT(0.027)AWS(0.97)DEESDY(0.002)EIDDRDVNK;NT(0.001)FT(0.069)AWS(0.93)DEES(0.001)DYEIDDRDVNK;NT(0.002)FT(0.019)AWS(0.952)DEES(0.007)DY(0.02)EIDDRDVNK;NT(0.001)FT(0.019)AWS(0.981)DEESDYEIDDRDVNK;NT(0.001)FT(0.008)AWS(0.549)DEES(0.002)DY(0.44)EIDDRDVNK 107.95 3.12e-05 66228200.0 99057.6 90264.3 101113.6 97497.8 90996.4 67383.3 78651.5 71713.2 53805.8 87894.2 True False 93552.37515099137 97187.28156453006 94608.0610601638 84218.4314469138 79564.61871386251 76664.73793030494 82308.95059499062 71921.87353924071 64568.463459663246 85356.46606944277 1.0960197798592168 1.1386047951594223 1.1083877463154845 0.9866672710934037 0.9321451833436001 0.8981714152497061 0.9642966067506495 0.8426060362050113 0.7564566158014648 1.0 16.38121282645183 -6.020705243330148 1.2881974271604517 0.8835085051242324 1.1305211817717382 0.6985833410468456 0.06332441978873354 0.24973725034020433 0.8418516081932135 0.023884606525176787 0.043648074928597826 9.534430484811624e-07 6.020705243330148 0.2470126766475058 NTFTAWSDEES(ph)DYEIDDR ddPTM_A459_Selumetinib_30min_R1 1 NTFTAWSDEESDYEIDDR 18 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50 Q6PKG0 LARP1 La-related protein 1 1 NTFTAWS(0.023)DEES(0.977)DYEIDDR 197.94 2.2654e-10 4389900.0 1196.7 2015.1 909.4 1125.3 1270.8 1191.4 1800.6 1413.2 830.5 1355.6 True False 1224.5807816271492 1779.1711552054246 785.9084749766324 928.787479497154 1155.8563643779632 1179.4155977046494 1664.7792923286222 1375.7173452794564 1409.297842679929 1529.6044646621885 0.8005865633358991 1.1631576635063972 0.5137984970187698 0.607207615402898 0.7556570283895143 0.7710592018735524 1.088372406585703 0.899394174809291 0.921347887796059 1.0 10.578942924087501 -7.232627741803224 21.45785319345198 0.9688946961318207 0.767009827753262 0.2783922846768081 0.16437518366512505 185.91749423641164 138463.96083375884 0.06688023739365356 0.05178194049225084 5.852915554648901e-08 7.232627741803224 -0.20188486837855868 NTGIICT(ph)IGPASR ddPTM_A459_Selumetinib_30min_R2 2 NTGIICTIGPASR 13 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 NT(0.038)GIICT(0.962)IGPASR;NTGIICT(0.748)IGPAS(0.252)R 128.45 0.0042678 15076400.0 127424.0 114258.0 124616.0 123590.0 111530.0 94365.0 109412.0 112683.0 86879.0 120229.0 True False 120342.28419868764 123021.22120262498 116598.34223164218 106756.8287953582 97518.60430914945 107362.92218981871 114499.8747957651 113010.888874325 104257.2276020817 116757.67637754293 1.0307012603569952 1.0536456789772735 0.9986353432952405 0.9143452671167728 0.8352222083781217 0.9195363039142221 0.9806624998730098 0.9679097116398371 0.8929368144066152 1.0 16.833157879256085 -5.593515381594221 3.751731160010971 0.9267018444210665 1.0399555828732543 0.5116684721513663 0.044819048240335085 0.18317168558485972 5.116482564100509 0.013312034735230174 0.025089064075350078 2.549673783308494e-06 5.593515381594221 0.11325373845218778 NTGIICTIGPAS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 NTGIICTIGPASR 13 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 NTGIICTIGPAS(1)R;NTGIICTIGPAS(1)R 150.12 0.00050097 41738000.0 7266.700000000001 11131.599999999999 9374.5 10439.2 8443.2 9255.3 9105.2 8688.4 4304.9 8299.4 True False 7435.999971463193 9828.307097059555 8101.494390442538 8616.189688053575 7679.5140507680335 9162.200085140032 8418.38743336143 8457.95540809937 7305.100882544039 9364.708833001889 0.7940449728942142 1.0495048241568294 0.865109053032413 0.9200702169927077 0.8200483525664876 0.9783753289639714 0.8989481235865491 0.9031733456883297 0.7800670595118081 1.0 13.193018423635 NTGIICTIGPAS(ph)R ddPTM_A459_Selumetinib_30min_R2 4 NTGIICTIGPASR 13 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 NTGIICTIGPAS(1)R;NTGIICTIGPAS(1)R;NTGIICTIGPAS(1)R;NTGIICTIGPAS(1)R 145.33 0.00063009 55146000.0 128892.0 129850.0 157884.0 131379.0 139027.0 96697.0 82974.0 109221.0 72811.0 150528.0 True False 121728.69863555719 139809.07746644286 147725.91533110198 113484.95355858376 121561.18534285057 110016.13402203044 86832.45540986185 109538.81502749008 87375.2345093197 146181.86552128667 0.832720927465735 0.9564050709565215 1.0105625263729479 0.7763271672166363 0.8315750035708027 0.7525976880217754 0.5940029230042732 0.7493324472011154 0.5977159629051 1.0 17.157404824405496 -6.258392095355653 1.4450451930593915 0.7164857890036629 0.9288465796415089 0.2835290520799739 0.1192768438693301 0.44314234677756553 1.8564268369766117 0.043240166043630124 0.06006639451166126 5.515792305271294e-07 6.258392095355653 0.21236079063784596 NTGIICTIGPASR ddPTM_A459_Selumetinib_30min_R1 1 NTGIICTIGPASR 13 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 151.66 0.006364 17476000.0 674.89 610.34 861.95 884.16 635.06 593.84 682.74 661.42 543.36 513.19 False True 690.6136238926603 538.8811090606317 744.9019243524397 729.7580537387396 577.6189351289495 587.8665087635798 631.2403721228725 643.8769930050505 922.0422345557683 579.0629353939132 1.1926400079861157 0.9306088787983858 1.286391994413721 1.2602396201413142 0.9975063155026812 1.0152031373993533 1.090106676735345 1.111929211229945 1.5923005569827053 1.0 9.177576345668697 -8.066346388990006 24.999962297549356 1.3148057297655147 1.1075010927101359 0.157416224124879 0.1705569872995183 304.0707943303486 114574.32421860241 0.10948356850068092 0.041380940031017825 8.583286539617051e-09 8.066346388990006 -0.20730463705537883 NTGIICTIGPASR ddPTM_A459_Selumetinib_30min_R2 1 NTGIICTIGPASR 13 0 P14618;B4DNK4;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 134.61 0.016677 13942000.0 22706.0 19513.0 20653.0 16595.0 15690.0 16881.0 16315.0 12430.0 14381.0 18150.0 False True 21444.09141931974 21009.584355815914 19324.20846528619 14334.732372028244 13718.881929620316 19206.20451953935 17073.679827559186 12466.16924210273 17257.60183871288 17625.962340636663 1.2166196094655426 1.1919680724256576 1.0963491293030974 0.8132737432996503 0.7783337819797463 1.0896542355170837 0.9686665327881594 0.7072617654107868 0.9791012544560742 1.0 14.105414407339609 -5.585295151944848 4.353706629535899 0.8987171095011083 1.1936034371343527 0.5629043100021279 0.10857327635796586 0.15007681819936883 5.702325557678919 0.030941120318197114 0.056882995618239694 2.598393062642261e-06 5.585295151944848 0.2948863276332444 NTGNGTQSSMGSPLT(ph)RPTPR ddPTM_A459_Selumetinib_30min_R2 1 NTGNGTQSSMGSPLTRPTPR 20 1 E3W994;J3KR49;O75122;A0A0U1RQI6;H7C4I5;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 NTGNGTQS(0.002)S(0.002)MGS(0.014)PLT(0.95)RPT(0.031)PR 71.637 0.013201 12233000.0 8748.6 9461.9 12076.0 10472.0 10721.0 7367.2 9629.3 10688.0 8612.2 8831.0 True False 8262.387835420624 10187.597305196265 11299.043307354665 9045.695534792394 9374.132133043946 8381.964927217014 10077.081530095962 10719.100310506346 10334.880644973447 8576.026084306466 0.9634284870635156 1.187915848791419 1.3175150350849716 1.0547653943526816 1.0930624558381368 0.9773716689779465 1.175029253763153 1.2498912905735626 1.2050896934520248 1.0 13.06609357847577 NTGVSPASRPSPGTPT(ph)SPSNLTSGLK ddPTM_A459_Selumetinib_30min_R2 1 NTGVSPASRPSPGTPTSPSNLTSGLK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 NTGVS(0.002)PAS(0.004)RPS(0.015)PGT(0.174)PT(0.575)S(0.174)PS(0.046)NLT(0.008)S(0.003)GLK 53.481 0.020334 47519000.0 77690.0 59823.0 72025.0 74842.0 91488.0 53434.0 61569.0 69197.0 39873.0 68779.0 True False 73372.3008177112 64411.23173873706 67390.98991489067 64648.39049034873 79994.45952690278 60794.04847444266 64432.080496659015 69398.3518138199 47848.714144704725 66793.17156069702 1.0985000278214896 0.9643385728465458 1.0089502914777806 0.967889216513708 1.1976442749721703 0.9101835869434232 0.9646507119085906 1.0390036914290777 0.7163713449543733 1.0 16.02741299932861 -8.227391516399965 24.94785973352172 0.8581855168354038 1.0155712743116088 0.2931231379373668 0.09972017474648015 632.218444245462 463246.23640572716 0.06368894428499754 0.024069076261336347 5.923910433663227e-09 8.227391516399965 0.15738575747620498 NTGVSPASRPSPGTPTS(ph)PSNLTSGLK ddPTM_A459_Selumetinib_30min_R1 1 NTGVSPASRPSPGTPTSPSNLTSGLK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 NTGVSPASRPSPGTPT(0.011)S(0.984)PS(0.004)NLTSGLK 133.47 2.8161e-09 58725000.0 2295.3 2672.2 3125.4 3386.2 2765.4 2439.1 2792.5 2493.1 1897.0 2461.5 True False 2348.776024123671 2359.337581727922 2700.9878465933234 2794.863736846406 2515.2700582710245 2414.5648685256083 2581.8594767453533 2426.9748892698917 3219.0704486018367 2777.457502040408 0.8456568723007232 0.8494594714751452 0.9724677495908011 1.0062669671068634 0.9056016361810136 0.8693435873462664 0.9295765911264664 0.8738117099854666 1.1589989932292415 1.0 11.439549121725738 -8.252301241784513 24.997516648806094 1.0794995004913774 0.9096423222824699 0.5639131702415949 0.060795841353819886 434.62687445217375 1188936.633183072 0.04356131040602676 0.015934240950726316 5.593694687461716e-09 8.252301241784513 -0.16985717820890756 NTLDSEVPAAYQT(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 NTLDSEVPAAYQTPK 15 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 NTLDSEVPAAY(0.001)QT(0.998)PK;NTLDSEVPAAYQT(1)PK;NTLDSEVPAAYQT(1)PK 173.34 7.7105e-05 18957200.0 8005.0 11516.4 9712.5 9114.9 8565.0 8469.5 9696.300000000001 9018.5 5107.799999999999 7833.0 True False 8191.500924981468 10168.054534170895 8393.595846943634 7523.153822863779 7790.297262273569 8384.30451969072 8964.900284464087 8779.300083783453 8667.563541048208 8838.441849881177 0.9268037357842202 1.1504351905995278 0.949669182589743 0.8511855314141055 0.8814107050303556 0.9486179421776065 1.0143077746882059 0.9933085755269726 0.9806664668122168 1.0 13.109576340524868 -10.088029831231431 14.891841670046581 1.0000076968137852 0.9670044180345855 0.016769751220784057 0.07730328722086736 0.0 0.0 0.08063309757701144 0.0195563987194561 8.165262831002401e-11 10.088029831231431 -0.03300327877919973 NTLDSEVPAAYQT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 NTLDSEVPAAYQTPK 15 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 NTLDSEVPAAYQT(1)PK;NTLDSEVPAAYQT(1)PK 143.83 0.00087885 20215800.0 168016.0 131308.0 151473.0 157413.0 147459.0 127791.0 157954.0 147900.0 110607.0 146116.0 True False 158678.34334133833 141378.90137823368 141727.39209133256 135973.07784742906 128933.88211981414 145393.0502788018 165299.1739799131 148330.364513837 132731.4906177953 141897.25142503966 1.118262276032624 0.9963470043175585 0.9988029413395872 0.9582502584220937 0.908642562311549 1.0246361280338743 1.1649216057383325 1.0453364178952809 0.9354056494033898 1.0 17.114487118846768 -6.993860279028358 24.997669222856818 1.0479918027579935 0.9913797022643658 0.055056783367608 0.07265015170249683 377.536926100426 1537115.2507064217 0.026783941770135197 0.023559081188735582 1.0142376332034608e-07 6.993860279028358 -0.05661210049362775 NTLQLHR ddPTM_A459_Selumetinib_30min_R1 2 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 ; 118.74 0.014963 17262600.0 20013.3 17401.5 22620.7 22051.4 20598.5 16234.2 16766.6 18701.7 11026.2 16654.0 False True 20479.57095089716 15364.12429026213 19548.933186610866 18200.536946044198 18735.369311960545 16070.898687474239 15501.8818631329 18205.670164317 18710.65607821484 18791.703123697316 1.0898198431557464 0.8176014802451391 1.0402959783862615 0.9685411070108049 0.9970021976525517 0.8552124616745355 0.8249322459540253 0.9688142710896014 0.9956870835523007 1.0 14.197808206113898 -6.723569655796844 24.99863687347777 0.9204800762641404 0.9759011433922457 0.08609085596227828 0.08389717056362017 427.23191044953427 282023.9921568256 0.027513773855179172 0.0275132516475013 1.8898630947608123e-07 6.723569655796844 0.05542106712810524 NTLQLHR ddPTM_A459_Selumetinib_30min_R2 4 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 ;;; 120.46 0.013218 19263600.0 262159.0 217598.0 249982.0 272852.0 291707.0 200398.0 243682.0 241230.0 181056.0 247022.0 False True 247589.25228562712 234287.0669121527 233898.43027982253 235689.08690404586 255060.15876633264 228001.0054680794 255013.6958467228 241931.93936222396 217272.2591273204 239889.83301976547 1.032095646442954 0.9766444203279296 0.9750243573705382 0.982488853058756 1.063238719021982 0.9504404692686309 1.0630450346168328 1.0085126839964502 0.9057168300643174 1.0 17.87201248924704 -8.218161592093388 24.394606591816867 0.9528583412063456 1.0055117614998397 0.21119837234140038 0.04138665740082008 457.6863576675907 257986.98440212675 0.026690969221659935 0.01008810123296535 6.051156816938985e-09 8.218161592093388 0.05265342029349407 NTPS(ph)PDVTLGTNPGTEDIQFPIQK ddPTM_A459_Selumetinib_30min_R2 2 NTPSPDVTLGTNPGTEDIQFPIQK 24 0 M0R3F6;M0R2Z9;Q8IX01-4;Q8IX01-3;Q8IX01 M0R3F6 SUGP2 SURP and G-patch domain-containing protein 2 1 NT(0.276)PS(0.723)PDVT(0.002)LGTNPGTEDIQFPIQK;NT(0.242)PS(0.74)PDVT(0.018)LGTNPGTEDIQFPIQK 103.05 1.7009e-06 2161900.0 40337.0 35248.0 39278.0 46286.0 44542.0 30367.4 39724.0 38701.0 28128.0 38132.0 True False 38095.23102180484 37951.408259816504 36750.8962426529 39981.7669521964 38946.23574946771 34550.23370218941 41571.24471161269 38813.61350270457 33754.38596198569 37031.030081165656 1.0287380863645066 1.0248542418785958 0.9924351594352426 1.079682819099637 1.0517189412258923 0.933007632422356 1.1226056801686495 1.0481375597068674 0.9115162577979028 1.0 15.176447060636635 -8.246946898099408 24.82006102452479 0.9557581256321543 1.034928163602699 0.276433264105283 0.05137575727492254 810.5302651977997 1388134.0349743827 0.034401112711613675 0.012870022840939887 5.663085282803372e-09 8.246946898099408 0.07917003797054467 NTPSQHSHS(ph)IQHSPER ddPTM_A459_Selumetinib_30min_R2 1 NTPSQHSHSIQHSPER 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 NT(0.001)PS(0.001)QHS(0.001)HS(0.581)IQHS(0.416)PER 49.14100000000001 0.046576 405010.0 0.0 0.0 0.0 0.0 626.91 484.82 0.0 0.0 0.0 526.94 True False 0.0 0.0 0.0 0.0 548.1519611534912 551.5995542422295 0.0 0.0 0.0 511.7258730454591 0.0 0.0 0.0 0.0 1.0711828149146492 1.0779200022845596 0.0 0.0 0.0 1.0 8.999227368150487 -6.100009692271935 24.99958128618145 0.48165819667341003 1.1965345848764806e-05 0.2804240737740775 0.40837872578042067 66.33586121053419 16569.561575405984 0.13334810807143177 0.1721517271202806 7.943105076757711e-07 6.100009692271935 -0.4816462313275613 NTPSQHSHSIQHS(ph)PER ddPTM_A459_Selumetinib_30min_R1 7 NTPSQHSHSIQHSPER 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 NTPSQHSHS(0.008)IQHS(0.992)PER;NTPSQHSHSIQHS(1)PER;NTPSQHS(0.03)HS(0.258)IQHS(0.712)PER;NTPSQHS(0.007)HS(0.01)IQHS(0.982)PER;NTPSQHS(0.013)HS(0.014)IQHS(0.973)PER;NTPSQHSHS(0.01)IQHS(0.99)PER;NTPS(0.001)QHS(0.003)HS(0.004)IQHS(0.992)PER 113.49 0.0011799000000000002 41604280.0 14757.41 14145.689999999999 16644.72 21012.54 30457.26 17703.640000000003 23869.329999999998 13492.339999999998 3422.12 7046.08 True False 15101.228940078801 12489.506038647127 14384.458446902416 17343.094343226803 27702.40621066598 17525.55745521902 22068.847220792162 13134.479313903063 5807.087698244235 7950.513002631268 1.899403086955642 1.5709056804905108 1.8092490940071158 2.181380539530846 3.4843545569320757 2.2043303934499363 2.7757765081936663 1.6520291595719836 0.7304041508167266 1.0 12.956832237194186 -8.042340483987658 4.098009200247398 0.9062335773642639 2.2708755070968287 0.5442526703544021 0.5139325564456478 0.18936838808210613 6.69728620540304 0.4020714261643919 0.1489778521706079 9.071090838365944e-09 8.042340483987658 1.364641929732565 NTPSQHSHSIQHS(ph)PER ddPTM_A459_Selumetinib_30min_R2 12 NTPSQHSHSIQHSPER 16 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 NTPSQHSHSIQHS(1)PER;NTPSQHSHS(0.001)IQHS(0.999)PER;NTPSQHSHS(0.002)IQHS(0.998)PER;NTPS(0.002)QHS(0.039)HS(0.006)IQHS(0.952)PER;NTPSQHSHS(0.001)IQHS(0.999)PER;NT(0.007)PS(0.193)QHS(0.392)HS(0.009)IQHS(0.399)PER;NTPSQHSHS(0.023)IQHS(0.977)PER;NTPSQHSHS(0.002)IQHS(0.998)PER;NTPSQHS(0.006)HS(0.002)IQHS(0.992)PER;NTPS(0.001)QHS(0.014)HS(0.027)IQHS(0.958)PER;NTPSQHSHS(0.009)IQHS(0.991)PER;NTPSQHS(0.003)HS(0.053)IQHS(0.943)PER 139.2 0.00026639 236091200.0 31293.800000000003 28532.199999999997 53235.08000000001 94213.54 99808.6 44049.23 27518.14 36134.04 37955.060000000005 88638.13 True False 29554.615875006955 30720.52799451703 49809.9929107726 81381.49332457819 87269.75136779484 50116.611593402566 28797.78803615995 36239.18407408765 45547.13255298364 86078.91687738041 0.34334325926878895 0.35688794781512506 0.5786549682278999 0.9454288724439491 1.0138342178737074 0.5822170330604157 0.33455100367006774 0.4209995361083648 0.5291322684492605 1.0 16.39337230426714 -5.332123831712937 4.0987538523025675 0.6653439477319278 0.34684681973472 0.255135822385953 0.2255120150346613 0.34903123367197925 11.31809139711159 0.06745435696296442 0.1559319380157393 4.654533584616421e-06 5.332123831712937 -0.31849712799720786 NTS(ph)ASDEDERMSVGSR ddPTM_A459_Selumetinib_30min_R1 1 NTSASDEDERMSVGSR 16 1 Q32MZ4-2;Q32MZ4;C9JTC6;Q32MZ4-4 Q32MZ4-2;Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 NT(0.181)S(0.508)AS(0.309)DEDERMS(0.002)VGSR 78.225 0.014603 8252800.0 1776.5 1561.7 3157.0 3426.0 2603.5 2019.0 1938.5 1822.7 1271.5 1545.3 True False 1817.8889935327406 1378.8554379853674 2728.296740159699 2827.7134139849377 2368.0138846852574 1998.6906931053256 1792.277384304697 1774.356075035992 2157.6426333143045 1743.6543074966642 1.0425741993220285 0.7907848660466233 1.5647004847403896 1.621716759926249 1.3580753217562809 1.1462654521094913 1.0278857320507757 1.0176077146756262 1.2374256892766757 1.0 10.767898328047952 -6.945663202139304 5.292436607969355 1.0736999217982222 1.282999759361546 0.14891941874609715 0.23183751910042902 0.43869938434106726 26.11103967255899 0.09416402056440984 0.08200492142319032 1.1332788868157472e-07 6.945663202139304 0.20929983756332393 NTS(ph)LPPLWSPEAER ddPTM_A459_Selumetinib_30min_R1 1 NTSLPPLWSPEAER 14 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 NT(0.031)S(0.822)LPPLWS(0.147)PEAER 153.41 0.00036383 13239000.0 1460.8 1850.7 1566.0 1500.8 1576.3 1069.7 1300.0 1237.9 779.52 908.22 True False 1494.833797778006 1634.019183632911 1353.345801422264 1238.7134535051348 1433.723943318369 1058.93978920989 1201.9399533639948 1205.066870734106 1322.788506111809 1024.7988838119602 1.4586606419960664 1.594477911172995 1.320596482685659 1.2087380978572824 1.3990295715246333 1.0333147371032796 1.1728544715945828 1.1759057213758861 1.2907786366739709 1.0 10.001125094103946 -5.564470417504097 0.9039099790610645 1.1617791351286373 1.577353990260988 0.590097422622734 0.11295676696545731 0.6137698244189226 0.8163610819959071 0.04455577753505649 0.2003393895742092 2.7260234189993433e-06 5.564470417504097 0.4155748551323508 NTSAS(ph)DEDER ddPTM_A459_Selumetinib_30min_R2 1 NTSASDEDER 10 0 Q32MZ4-2;Q32MZ4;C9JTC6;Q32MZ4-4 Q32MZ4-2;Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 NT(0.002)S(0.092)AS(0.907)DEDER 84.734 0.037455 2153200.0 2279.5 1035.5 2067.6 2520.7 831.51 2262.8 4657.8 11400.0 3285.1 6261.0 True False 2152.8145155614966 1114.9195203427146 1934.572867032669 2177.3763115499596 727.0482800062839 2574.4801603467595 4874.396929255603 11433.172112628405 3942.2117933631666 6080.228661968384 0.35406801869595395 0.1833680248436209 0.31817436063438764 0.3581076358475417 0.11957581209962469 0.4234183126121625 0.8016798709799821 1.8803852204017415 0.6483657132866668 1.0 12.569909865450125 -7.380828622362527 3.222844270831851 1.2151572414621634 0.2792110495064983 0.632899347777473 0.30146410067885354 0.1451399159708745 2.83820577638608 0.1302245157631576 0.08242250157835596 4.1607476602941547e-08 7.380828622362527 -0.9359461919556651 NTSGLPAEPESVS(ph)SPPTLHMK ddPTM_A459_Selumetinib_30min_R2 1 NTSGLPAEPESVSSPPTLHMK 21 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 NTSGLPAEPESVS(0.706)S(0.294)PPTLHMK 124.66 4.7038e-05 7792000.0 19069.0 16239.0 15214.0 16931.0 19810.0 13561.0 13585.0 13424.0 9231.1 17253.0 True False 18009.22131925519 17484.479083385162 14235.147803750728 14624.96859239592 17321.290696353004 15428.904655498683 14216.72941816682 13463.061617537172 11077.57793848428 16754.861061322554 1.0748654526791774 1.0435466471128718 0.84961300196106 0.8728791327405666 1.033806883444591 0.9208613905557982 0.8485137158782632 0.8035316776583559 0.6611560607957597 1.0 14.032292102679596 -7.286146985670494 2.408104760392796 0.8025506121468844 0.9666981271142648 0.3068989669993911 0.10217301835784083 0.3646660322836583 4.155466233737508 0.049960083442650655 0.03236384610613096 5.17431679105641e-08 7.286146985670494 0.16414751496738045 NTSGLPAEPESVSS(ph)PPTLHMK ddPTM_A459_Selumetinib_30min_R1 2 NTSGLPAEPESVSSPPTLHMK 21 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 NTSGLPAEPESVS(0.039)S(0.951)PPT(0.01)LHMK;NTSGLPAEPESVS(0.015)S(0.984)PPT(0.001)LHMK 139.28 1.5512e-05 34105000.0 6485.0 9948.9 10304.8 12507.599999999999 9253.2 8857.9 8893.6 7446.0 3712.1 6441.8 True False 6636.087882386611 8784.07816288187 8905.464760214652 10323.3824567303 8416.249693785147 8768.797568329706 8222.74859172156 7248.50789198332 6299.162578943 7268.667778445622 0.9129716867876597 1.2084853002815754 1.2251852790167077 1.4202578479846162 1.1578806392476133 1.2063830450928767 1.1312593782460594 0.9972264674797652 0.8666185841678476 1.0 12.827475251894594 -7.743347033840804 2.3693669183648303 0.9309293082387289 1.1996062190578007 0.43696264604687085 0.1196026360549862 0.2784134214081121 3.117508069106798 0.08037810931078218 0.03532744098425229 1.8057306352445376e-08 7.743347033840804 0.26867691081907186 NTSGLPAEPESVSS(ph)PPTLHMK ddPTM_A459_Selumetinib_30min_R2 3 NTSGLPAEPESVSSPPTLHMK 21 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 NTSGLPAEPESVS(0.219)S(0.781)PPTLHMK;NTSGLPAEPESVS(0.273)S(0.726)PPT(0.001)LHMK;NTSGLPAEPESVS(0.317)S(0.682)PPTLHMK 115.58 5.1001e-05 35000000.0 79530.0 81407.0 94480.0 93054.0 93773.0 73872.0 67644.0 75724.0 59941.0 88194.0 True False 75110.04098381489 87650.65513523818 88401.25966204594 80379.88467289662 81992.39739874356 84047.19745675093 70789.58003404309 75944.34430321696 71930.87489147406 85647.61006446875 0.876965988044243 1.0233870515389945 1.0321509216136264 0.9384953603771663 0.9573226542693505 0.9813139840503061 0.8265213703074527 0.8867071042151913 0.8398468426302867 1.0 16.386125369043256 -7.243747219771103 24.44241732326906 0.8788277539144809 0.9718301829357 0.2948250015093854 0.059756011375257434 661.1356374454816 913386.1704829688 0.02207531361403604 0.017058971141839595 5.7049623184643634e-08 7.243747219771103 0.09300242902121914 NTSLPPLWS(ph)PEAER ddPTM_A459_Selumetinib_30min_R1 3 NTSLPPLWSPEAER 14 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 NTSLPPLWS(1)PEAER;NTSLPPLWS(1)PEAER;NTSLPPLWS(1)PEAER 214.54 1.1089e-06 163073000.0 11473.4 12814.8 14690.4 14789.099999999999 12420.0 11594.0 11813.3 10475.6 7066.3 10564.1 True False 11740.707896649896 11314.437258561109 12695.52436859107 12206.461310789446 11296.613192929099 11477.374886509737 10922.213270057604 10197.753058455608 11990.99499786777 11920.10513804796 0.9849500286012206 0.9491893844498392 1.0650513750980297 1.024022956964319 0.9476940901193288 0.96285852797346 0.916284977654671 0.8555086503310486 1.0059470834358277 1.0 13.541109340305184 -6.350288774441581 5.203878409715895 0.9391109748426514 1.0058268913922381 0.24137644632646282 0.04875280944911169 0.29956630774172643 13.30457793527499 0.015633120425349006 0.017828397901309724 4.463866785704727e-07 6.350288774441581 0.06671591654958675 NTSLPPLWS(ph)PEAER ddPTM_A459_Selumetinib_30min_R2 5 NTSLPPLWSPEAER 14 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 NTSLPPLWS(1)PEAER;NTS(0.044)LPPLWS(0.956)PEAER;NTSLPPLWS(1)PEAER;NTSLPPLWS(1)PEAER;NTS(0.001)LPPLWS(0.999)PEAER 180.03 7.1606e-05 56618100.0 263559.0 262166.0 266265.0 317298.0 307841.0 208192.3 240473.0 232736.1 188442.7 276392.0 True False 248911.4458902708 282273.2892034451 249133.7997874126 274081.4650304198 269167.2614465425 236868.8995434689 251655.47098820974 233413.3235194645 226136.5055289638 268411.8448073417 0.927348962818434 1.051642446726048 0.9281773684996416 1.0211228391472351 1.002814393827303 0.882483035402132 0.9375721521113973 0.8696088791722357 0.8424982350956907 1.0 18.03408881239725 -6.7600611629023195 24.995445789633433 0.9002292397511882 0.9885700459452792 0.3545771327742816 0.053451021520189324 37.09383438510203 672740.5956023672 0.017228443437425765 0.016343871697199436 1.7375561066480466e-07 6.7600611629023195 0.08834080619409101 NTSSDNS(ph)DVEVMPAQSPR ddPTM_A459_Selumetinib_30min_R2 1 NTSSDNSDVEVMPAQSPR 18 0 Q9HCK8-2;Q9HCK8;A0A2R8Y840;A0A2R8YFT4;A0A2R8Y4P3 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 NTS(0.008)S(0.038)DNS(0.935)DVEVMPAQS(0.019)PR 104.68 0.0017855999999999996 3963400.0 17920.0 15655.0 16497.0 15624.0 15658.0 12129.0 14915.0 13205.0 11635.0 13721.0 True False 16924.07813944376 16855.688161241134 15435.600980575517 13495.984247096663 13690.902055703946 13799.659653900408 15608.577053511819 13243.42436379457 13962.325109062262 13324.839078560632 1.270115011495653 1.2649824933617067 1.1584080595322952 1.0128440702005475 1.0274722249916175 1.0356342446269202 1.1713895350995773 0.993890003902782 1.047841930903866 1.0 13.701830489497171 -5.496124634499038 2.8963342038684123 1.0458467702458407 1.2675290926282252 0.7839024630639919 0.04777360162724164 0.1190054853748127 1.9881147641459336 0.013653294514570528 0.030593623986517698 3.1906220740659574e-06 5.496124634499038 0.2216823223823845 NTVDLVTTCHIHSSS(ph)DDEIDFK ddPTM_A459_Selumetinib_30min_R2 2 NTVDLVTTCHIHSSSDDEIDFK 22 0 E9PQP7;Q5H9R7-2;Q5H9R7;Q5H9R7-5;H0YDW1 E9PQP7 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 NTVDLVTTCHIHS(0.207)S(0.207)S(0.587)DDEIDFK;NTVDLVT(0.002)T(0.004)CHIHS(0.159)S(0.159)S(0.677)DDEIDFK 101.0 6.534100000000001e-05 9676300.0 81682.0 50269.0 65276.0 111101.0 92819.0 79260.0 91667.0 86394.0 80232.0 84225.0 True False 77142.44143895346 54124.47065968897 61076.21322713503 95968.85214008509 81158.24740761174 90177.34554935666 95929.69713471459 86645.39223670342 96280.64186938414 81793.20540716931 0.9431399717731541 0.6617233105152872 0.7467149981846976 1.1733108106272268 0.9922370324479065 1.1025041151089607 1.172832103316814 1.0593226149455786 1.1771227376417868 1.0 16.319693382465616 -5.756068737420103 24.999907331815358 1.098286846923464 0.7716457299917547 0.7145307055049652 0.09053086216769088 63.73303540838534 296667.881349356 0.023735224753646044 0.039628478399105674 1.75360293054885e-06 5.756068737420103 -0.32664111693170916 NVAEALGHS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 NVAEALGHSPK 11 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 NVAEALGHS(1)PK 90.444 0.027818 17746000.0 1610.4 2364.7 1634.3 1321.2 1245.4 1482.8 1929.0 1788.0 980.95 1924.2 True False 1647.9191867070786 2087.839824680795 1412.3710365673094 1090.4772219955926 1132.7537898932292 1467.8843782746794 1783.49397695319 1740.5764317574778 1664.6005042466902 2171.189813295206 0.7589936064622734 0.9616109157734528 0.650505555948496 0.5022486819522148 0.5217202949999352 0.6760737220146024 0.821436230969778 0.8016693985478 0.7666766369543402 1.0 11.084270141766309 -8.597380864799355 0.7836367664229346 0.9926177769571674 0.6867405434740187 0.3364967915143331 0.12726786355716393 1.028354979188686 1.3921550151353852 0.1424424060258117 0.05234639488456715 2.5270808411882718e-09 8.597380864799355 -0.30587723348314866 NVAEALGHS(ph)PKDPGGGGGPVR ddPTM_A459_Selumetinib_30min_R2 2 NVAEALGHSPKDPGGGGGPVR 21 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 NVAEALGHS(1)PKDPGGGGGPVR;NVAEALGHS(1)PKDPGGGGGPVR 55.177 0.01419 68755000.0 146382.0 138627.0 147488.0 150926.0 128426.0 93484.0 105562.0 98267.0 73229.0 119256.0 True False 138246.67445357452 149259.24514393968 137998.782652793 130369.61843812803 112291.97773699302 106360.57243674049 110470.84216713478 98552.94070102248 87876.84618921526 115812.76941570069 1.1937083894207652 1.2887978233918709 1.191567936325375 1.125692953340721 0.969599279108247 0.9183838101217294 0.9538744537798635 0.8509678267624753 0.7587837388966007 1.0 16.8214348068404 -6.211148496242653 1.1654015525612236 0.8779004130751002 1.2507035723922981 0.8423132283264718 0.06368613593412709 0.17345882787521477 0.48477369103480705 0.026187024211583917 0.04069211937824661 6.149665641702334e-07 6.211148496242653 0.3728031593171979 NVALLSQLYHS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 NVALLSQLYHS(1)PAR;NVALLSQLYHS(1)PAR 192.62 6.8289e-05 123557000.0 8966.3 11847.6 9157.9 10707.9 9991.7 8191.0 10873.3 9120.1 4443.9 8646.1 True False 9175.197344617285 10460.477484200193 7914.307480743904 8837.96627717726 9087.952499177909 8108.605976832947 10053.118226855944 8878.205321740135 7540.973730385715 9755.911155145868 0.9404756971139207 1.0722194285956257 0.811232016659911 0.9059088522465246 0.9315329295905246 0.8311479930355833 1.0304643069195347 0.9100334331209262 0.7729645760876103 1.0 13.252060904561857 -5.254003701328958 24.99871133013964 0.8996049938254612 1.0063475559028758 0.21891349639614732 0.08098355133126542 840.3857073359203 2825355.16997223 0.02001134601439661 0.05077361741693692 5.571810002670366e-06 5.254003701328958 0.10674256207741462 NVALLSQLYHS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 NVALLSQLYHS(1)PAR;NVALLSQLYHS(1)PAR 159.18 0.00019857 46448300.0 123814.0 106519.0 129017.0 148333.0 153868.0 111764.0 125963.0 128410.0 109016.0 121761.0 True False 116932.91354671246 114688.66478743182 120716.18668308853 128129.78951130265 134537.72624262716 127158.47650742244 131820.5290909493 128783.65184058 130822.24616154106 118245.44355692908 0.9888999527530656 0.9699203735678419 1.0208950387586808 1.0835917702792055 1.137783598214118 1.0753773903025887 1.1148043013385502 1.0891214745080415 1.1063618370931723 1.0 16.85142506658945 -5.637600525920442 2.8256336583130977 1.0939693286232823 0.9807513322974106 0.6152550701775047 0.03460547521899307 0.14870897107565134 2.37745185470278 0.009196111346289705 0.018030744862225927 2.303559710559008e-06 5.637600525920442 -0.1132179963258717 NVALLSQLYHS(ph)PARR ddPTM_A459_Selumetinib_30min_R1 1 NVALLSQLYHSPARR 15 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 NVALLSQLYHS(1)PARR 72.383 0.023695 15016000.0 1585.5 1572.0 2337.5 2468.5 2076.5 1825.8 1985.4 1687.1 771.57 1282.1 True False 1622.4390651540434 1387.9495091970266 2020.0803389684163 2037.4228144838921 1888.6809416358506 1807.434109693762 1835.63967954529 1642.3526275268682 1309.2979367568369 1446.6700237115601 1.1214990554594697 0.9594098767845615 1.396365657584942 1.4083535160676817 1.3055367918596061 1.24937551761571 1.2688724100578193 1.1352641587977796 0.9050425565587631 1.0 10.498520174435386 -8.057126246109865 3.417180312272884 0.9558143721910267 1.2471419204797742 0.45983490744744415 0.1249998282917743 0.24691117131610116 5.531335557738629 0.10439302224575105 0.03675442969908999 8.767459207114227e-09 8.057126246109865 0.2913275482887475 NVALLSQLYHS(ph)PARR ddPTM_A459_Selumetinib_30min_R2 1 NVALLSQLYHSPARR 15 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 NVALLS(0.001)QLY(0.288)HS(0.712)PARR 67.095 0.042126 2066200.0 14945.0 17745.0 17932.0 21299.0 19804.0 13560.0 10049.0 8946.9 7341.4 21431.0 True False 14114.416729575169 19105.984440831933 16778.27464288539 18398.039457175637 17316.044469993678 15427.766914575772 10516.298411715736 8972.933997760965 8809.885135854718 20812.231345574895 0.6781789273439045 0.9180171084776191 0.8061737525540621 0.884001294800494 0.8320128765854519 0.7412836547127865 0.5052941338724699 0.4311375291178855 0.4233032484394269 1.0 14.345144028842856 -7.099845659351474 3.509825957369652 0.543342332341027 0.8292510366166453 0.29188644378600326 0.1649444608162921 0.2491432919470567 5.698200941168337 0.06293439838093301 0.048322492056758315 7.946105752259844e-08 7.099845659351474 0.2859087042756183 NVDAAVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 NVDAAVSPR 9 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 NVDAAVS(1)PR;NVDAAVS(1)PR 122.55 0.0059098 116902000.0 7131.5 6037.1 8035.0 8479.8 6866.4 6394.8 6065.6 6200.9 3706.8 5164.0 True False 7297.6500745166 5330.273525428353 6943.8911330957135 6998.962115560262 6245.33533236138 6330.474118013836 5608.0669085574245 6036.431988638107 6290.168866039685 5826.849701619608 1.2524177640085987 0.9147779329106038 1.1917058940383545 1.2011571387562747 1.0718202205602543 1.0864316813001444 0.9624526452087186 1.0359683701744091 1.0795145212500152 1.0 12.50850038279806 -6.830361766394979 2.3278827702425455 1.0238048092010017 1.1258620277445164 0.23746690655462022 0.09009393099328714 0.4873820599312132 5.405465132762923 0.03526397143427689 0.03117304071363402 1.477876806998308e-07 6.830361766394979 0.10205721854351468 NVDAAVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 NVDAAVSPR 9 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 NVDAAVS(1)PR;NVDAAVS(1)PR 112.84 0.0094581 117220000.0 854990.0 756820.0 859240.0 929960.0 997140.0 750060.0 738140.0 806400.0 642140.0 866210.0 True False 807473.0785961495 814865.660440149 803957.4338697767 803297.8437295203 871870.3586552966 853373.9566332371 772464.9725966615 808746.4904932934 770585.9428906955 841200.2666161357 0.9599058757367501 0.9686940111396756 0.9557265561788582 0.9549424502216529 1.0364599171640023 1.0144718095086585 0.9182890249239066 0.9614196792240771 0.9160552765758174 1.0 19.682089781764844 -10.127437307755425 15.222865711443283 0.9999999999997359 0.9667028603052913 0.07966630352170412 0.035204912816781196 0.0 0.0 0.03619989929288748 0.008779765201252775 7.456975088467448e-11 10.127437307755425 -0.03329713969444459 NVDLLSDMVQEHDEPILK ddPTM_A459_Selumetinib_30min_R1 3 NVDLLSDMVQEHDEPILK 18 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8W543;H0YH88 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 ;; 190.8 3.2813000000000003e-10 21784000.0 10926.9 12025.199999999999 13294.3 13918.4 12379.400000000001 10513.2 12354.7 11001.699999999999 6338.200000000001 9178.3 False True 11181.47550995378 10617.283993636189 11489.007080362704 11487.812720726193 11259.685455760578 10407.446753221857 11422.775032173968 10709.899177441974 10755.46247618774 10356.424209212862 1.079665653325302 1.0251882096709857 1.1093604170966962 1.109245091612496 1.0872174824341585 1.0049266564383879 1.1029651549047692 1.0341309858584846 1.038530506177982 1.0 13.338238345303102 -8.379102459683127 0.6462589731062605 0.9995659756418117 1.0770913530779944 0.33084498389531714 0.033531246222346905 0.9315445205842671 0.9124272465109169 0.03430782628355093 0.014804380403153045 4.1773180283993235e-09 8.379102459683127 0.07752537743618271 NVDLLSDMVQEHDEPILK ddPTM_A459_Selumetinib_30min_R2 2 NVDLLSDMVQEHDEPILK 18 0 P55209;F8W020;P55209-2;P55209-3;F8W0J6;H0YIV4;B7Z9C2;H0YHC3;F8VV59;F5H4R6;F8VY35;F8VUX1;F8VXI6;F8W118;F8W543;H0YH88 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 ; 195.17 3.9495e-10 7067400.0 55417.0 52218.0 55471.0 67054.0 60060.0 47824.0 49677.0 49957.0 44144.0 58766.0 False True 52337.144991827816 56222.95269266621 51902.05625225825 57921.129525398064 52514.72585678754 54411.3218969522 51987.07893310804 50102.366599173416 52974.03348641554 57069.27288759525 0.9170809849796417 0.9851703000212395 0.9094571145927431 1.0149267126546477 0.9201926570927504 0.9534258830337964 0.9109469299793392 0.8779219370440554 0.9282409045363907 1.0 15.800426561485434 -7.254511255043191 24.050313352390898 0.9191042705243131 0.9513867175127163 0.03371890852245263 0.041810271615572776 691.3787954374601 2400059.14979432 0.015276004514454974 0.01154469487224475 5.565302112043374e-08 7.254511255043191 0.03228244698840321 NVFEVGPGDS(ph)PTFPR ddPTM_A459_Selumetinib_30min_R1 2 NVFEVGPGDSPTFPR 15 0 Q16584;Q16584-2 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 NVFEVGPGDS(0.894)PT(0.106)FPR;NVFEVGPGDS(0.891)PT(0.109)FPR 160.64 0.00012729 30317000.0 4001.1000000000004 4315.1 4549.5 4631.2 4152.299999999999 3593.7 3854.2 4336.3 2352.14 4092.8 True False 4094.3178452146617 3809.8860859644356 3931.7028886146795 3822.447858390844 3776.725198148105 3557.550640818529 3563.4745909657768 4221.2872377124995 3991.4097864914734 4618.150747248013 0.8865708525548874 0.8249808840118031 0.8513587155979279 0.8277009711449255 0.8178003284970029 0.7703409515028276 0.7716237052437656 0.9140644099216537 0.8642874615710587 1.0 12.173099551485144 -8.654951194949238 1.1740649940507746 0.9973498963542308 0.8243579979973105 0.611359074146024 0.040743384872604656 0.44353706504120516 1.2704676269793185 0.04035830534849703 0.012566510498373496 2.2133434262560804e-09 8.654951194949238 -0.1729918983569203 NVFEVGPGDS(ph)PTFPR ddPTM_A459_Selumetinib_30min_R2 2 NVFEVGPGDSPTFPR 15 0 Q16584;Q16584-2 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 NVFEVGPGDS(0.987)PT(0.013)FPR;NVFEVGPGDS(0.5)PT(0.5)FPR 139.49 0.00039334 9758500.0 69594.0 70131.0 75518.0 85028.0 87633.0 68842.0 62843.0 73320.0 57681.0 69564.0 True False 65726.24408685545 75509.82219329303 70659.2540977815 73447.03971851876 76623.75909103996 78324.36061454473 65765.32402104216 73533.34906122067 69218.81174179808 67555.50657102196 0.9729220817514945 1.1177448889959636 1.0459436644664417 1.0872102578537095 1.1342340984518327 1.1594074945201 0.9735005680388503 1.0884878641819393 1.0246213114992702 1.0 16.0437857505648 -7.270983692996026 24.98159231255428 1.0290264308570694 1.0880691088859915 0.24201741065265114 0.05533161757556235 1101.8998737107993 2884135.650993702 0.022978283745268675 0.015728023350792493 5.358167761255356e-08 7.270983692996026 0.05904267802892216 NVFTS(ph)AEELER ddPTM_A459_Selumetinib_30min_R2 2 NVFTSAEELER 11 0 B8ZZF5;C9J5M4;Q9H8M9 B8ZZF5 EVA1A Protein eva-1 homolog A 1 NVFT(0.227)S(0.773)AEELER;NVFT(0.389)S(0.611)AEELER 125.36 0.0033649 2580000.0 38979.0 14564.5 26230.0 30004.0 18208.300000000003 16554.0 42425.0 28511.0 22141.0 19855.2 True False 36812.7032253001 15681.55031775129 24542.390357064654 25917.403440213042 15920.810569732672 18834.163237749814 44397.84656354267 28593.962289749852 26569.818671228844 19281.92878599499 1.9091815779362389 0.8132770581095208 1.2728182242271575 1.3441291961952262 0.8256855808583011 0.9767779689877082 2.30256252143147 1.4829409758280228 1.3779647755222109 1.0 14.234961752217426 NVGESVAAALS(ph)PLGIEVDIDVEHGGK ddPTM_A459_Selumetinib_30min_R1 1 NVGESVAAALSPLGIEVDIDVEHGGK 26 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 NVGESVAAALS(1)PLGIEVDIDVEHGGK 198.83 3.3553999999999997e-32 62283000.0 4793.1 6838.6 4422.8 3322.9 4318.4 3771.7 3427.9 4176.6 2408.7 3602.5 True False 4904.7699042509275 6037.933532821113 3822.2080527013964 2742.6178935582434 3927.801482475445 3733.7601224295995 3169.3307431818776 4065.8230004912107 4087.387975512513 4064.9159663215796 1.2066104059438523 1.485377208986919 0.9402920218693194 0.674704696549998 0.9662688023609471 0.9185331636285585 0.7796792773676612 1.0002231372498585 1.0055282838260662 1.0 11.989009812552979 -5.319277118500306 7.138417424143695 0.8985581932742429 1.3449676126762233 0.6812260974293076 0.11896278369983077 0.12217949705031168 13.074584498756028 0.030761693408810385 0.06500657149795609 4.794274336775815e-06 5.319277118500306 0.4464094194019804 NVGESVAAALS(ph)PLGIEVDIDVEHGGK ddPTM_A459_Selumetinib_30min_R2 2 NVGESVAAALSPLGIEVDIDVEHGGK 26 0 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 NVGESVAAALS(1)PLGIEVDIDVEHGGK;NVGES(0.001)VAAALS(0.999)PLGIEVDIDVEHGGK 120.66 5.1065e-09 8924900.0 42572.1 33514.2 35110.7 34272.9 37217.4 34680.6 40753.0 41485.4 41059.5 33785.4 True False 40206.11311161906 36084.63137486219 32851.71578763972 29604.871895949807 32541.81748422251 39457.53785085816 42648.095250537524 41606.1156457223 49272.547298284626 32809.92771698874 1.2254252267310124 1.09980831674243 1.001273641045827 0.9023144504101 0.9918283808767001 1.2026097159131302 1.2998533742107163 1.2680953156802888 1.501757264548061 1.0 15.001844795031605 -6.927969819026239 3.967480270358398 1.2864625706470363 1.0376808623525473 0.3696639917364002 0.13799270517595333 0.22536362316093644 7.018231666572069 0.051302944803841885 0.044295942798223256 1.1804026640114079e-07 6.927969819026239 -0.24878170829448898 NVGESVAAALS(ph)PLGIEVDIDVEHGGKR ddPTM_A459_Selumetinib_30min_R1 4 NVGESVAAALSPLGIEVDIDVEHGGKR 27 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 NVGESVAAALS(1)PLGIEVDIDVEHGGKR;NVGESVAAALS(1)PLGIEVDIDVEHGGKR;NVGESVAAALS(1)PLGIEVDIDVEHGGKR;NVGESVAAALS(1)PLGIEVDIDVEHGGKR 183.75 7.669400000000001e-27 49056200.0 12181.28 13647.800000000001 20979.05 10737.460000000001 12581.96 8430.9 6209.23 8553.26 5793.570000000001 4675.1 True False 12465.08012335519 12049.909231309915 18130.21023967288 8862.364178087184 11443.923939525454 8346.092800644721 5740.862782020249 8326.399759895952 9831.265144389103 5275.194624330334 2.3629611817284535 2.284258703125974 3.4368798747353217 1.680007053618847 2.1693842131897108 1.582139313334667 1.0882750667704568 1.5784061732040755 1.863678185264519 1.0 12.365008606610155 -6.356714223707247 1.369418903854941 1.4313799546311003 2.600350311132328 0.5561136940539154 0.4478958169263877 0.325092686216953 1.2371849352113935 0.17786445488329505 0.2293733801090265 4.398309396523224e-07 6.356714223707247 1.1689703565012277 NVHS(ph)EDFENR ddPTM_A459_Selumetinib_30min_R1 2 NVHSEDFENR 10 0 Q9H2P0;A0A669KBJ7 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 NVHS(1)EDFENR;NVHS(1)EDFENR 109.15 0.010248 91099000.0 5337.4 6159.2 6850.799999999999 7210.9 6279.6 5177.4 5675.6 5330.5 3186.8 4518.9 True False 5461.751035227497 5438.078000665606 5920.498988750733 5951.651680357263 5711.6112887534255 5125.320056703076 5247.484922548223 5189.117824095767 5407.766845337019 5098.944832813489 1.0711531923387803 1.0665104602955648 1.1611223856846336 1.167232020644018 1.1201555372784608 1.0051726827322889 1.0291315349753987 1.0176846375552024 1.0605658665958009 1.0 12.315983013713684 -6.754688585014792 24.98443714910148 1.024030018256649 1.119632554394347 0.6607997996789976 0.033902500630291973 106.85664745316696 395471.6115875503 0.01245459042742498 0.012180094851176092 1.759184601838699e-07 6.754688585014792 0.09560253613769798 NVIPDT(ph)PPSTPLVPSR ddPTM_A459_Selumetinib_30min_R1 1 NVIPDTPPSTPLVPSR 16 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 NVIPDT(0.462)PPS(0.355)T(0.108)PLVPS(0.075)R 91.932 0.02617 7237100.0 3048.7 3415.2 3069.6 3403.1 3760.8 2782.0 3316.9 3199.4 1770.9 2286.6 True False 3119.7287782624644 3015.3467963165954 2652.7651801058637 2808.812469098698 3420.636304023169 2754.015605853897 3066.7035625484905 3114.541518884157 3005.087958581438 2580.1073833701385 1.209146874417092 1.1686904257364463 1.0281607646270985 1.0886416926685527 1.3257728442120618 1.0674034823529706 1.1885953206113304 1.2071363924457827 1.164714297532915 1.0 11.333215396136831 -4.996789825327837 21.75424731770526 1.1428558680833216 1.1990331568676937 0.05631598819822803 0.09080627006879548 72.47134496506412 490862.999597476 0.022315503141455577 0.08381186561024201 1.0074190863979448e-05 4.996789825327837 0.056177288784372115 NVIPDT(ph)PPSTPLVPSR ddPTM_A459_Selumetinib_30min_R2 1 NVIPDTPPSTPLVPSR 16 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 NVIPDT(0.46)PPS(0.46)T(0.079)PLVPS(0.001)R 116.61 0.0044604 3369700.0 18947.0 25854.0 21288.0 31397.0 27067.0 22892.0 22890.0 25349.0 19052.0 27742.0 True False 17894.001590850483 27836.918666287354 19918.353256621896 27120.674437154004 23666.601477949847 26045.16520711422 23954.430355674514 25422.761393247154 22862.932357357484 26941.01637762768 0.6641917788116559 1.0332542126882656 0.7393319159689338 1.0066685702205176 0.8784598600965565 0.9667476847214499 0.8891435282139808 0.943645222470474 0.8486291696234329 1.0 14.71751665853465 -4.744131706501471 24.975590257613334 0.9169261571534244 0.6641910074054503 0.46065996291258526 0.08374904241233674 918.3802357645212 1325184.4217406677 0.018803536976923316 0.5525743829077848 1.8024710308179285e-05 4.744131706501471 -0.25273514974797406 NVKGMRNGPAQTRVS(ph)SSS(ph)SHQEAT(ph)LAMGDK ddPTM_A459_Selumetinib_30min_R2 1 NVKGMRNGPAQTRVSSSSSHQEATLAMGDK 30 3 Q6ZRI0 Q6ZRI0 OTOG Otogelin 3 NVKGMRNGPAQT(0.14)RVS(0.356)S(0.356)S(0.356)S(0.579)S(0.215)HQEAT(0.999)LAMGDK 44.164 0.025788 7369300.0 20674.0 23123.0 22753.0 22956.0 20899.0 22446.0 19256.0 19856.0 21469.0 22322.0 True False 19525.021844579256 24896.4597478364 21289.096751593293 19829.353198691184 18273.48078056948 25537.732755499113 20151.442155040128 19913.777672662247 25763.39989398003 21677.505860478872 0.9007042586101247 1.1484928159205867 0.9820823893954653 0.9147432977906776 0.842969707778264 1.1780752324490418 0.9296015088054492 0.9186378636376177 1.1884854309254422 1.0 14.403911154243378 -6.748304166539566 24.999687389407917 1.0307900098582263 0.9673498324651838 0.11844787676364199 0.11226548629993108 722.9041866827553 1375870.3571055182 0.037859834429007776 0.03764658109463931 1.7852368117778846e-07 6.748304166539566 -0.06344017739304253 NVMVEPHR ddPTM_A459_Selumetinib_30min_R2 1 NVMVEPHR 8 0 M0R2U2;M0R1H0;M0R2B0;M0R0P1;M0QXL5;M0R2Q4;P22087;M0QXC9 M0R2U2 FBL rRNA 2-O-methyltransferase fibrillarin 0 87.476 0.045547 2240400.0 16563.0 13421.0 19757.0 19980.0 24465.0 18441.0 19499.0 22095.0 18423.0 16095.0 False True 15642.494766942338 14450.34754468331 18485.856129795142 17258.689532577544 21391.48798012499 20981.08035926933 20405.742136535508 22159.292791975844 22108.114781629054 15630.29553016787 1.0007804866357723 0.9245089139097111 1.1826939608477514 1.1041819074544514 1.3685913960383862 1.3423342072306927 1.305525036116598 1.4177142555754256 1.41443997261334 1.0 13.932057435934173 -5.740174739612586 1.2088078165579865 1.3312813722047654 0.9550454185971655 0.5051838789074955 0.12541945615187602 0.37291748199291624 1.0622593088821664 0.04203492850734534 0.11442034709957298 1.818968844098982e-06 5.740174739612586 -0.37623595360759987 NVPESSPHS(ph)PCEGLPSEAALTPRPEGK ddPTM_A459_Selumetinib_30min_R1 1 NVPESSPHSPCEGLPSEAALTPRPEGK 27 1 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2;H0YCW2;S4R3B3;H7C453;S4R3U7 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 NVPES(0.047)S(0.108)PHS(0.843)PCEGLPS(0.002)EAALTPRPEGK 60.38800000000001 0.0020718000000000004 7838700.0 1055.5 1431.8 1542.4 1391.5 1375.8 1479.1 1586.7 1419.2 665.07 844.16 True False 1080.0910963545218 1264.1641903742393 1332.950551796743 1148.5006466900284 1251.3591329172184 1464.2215969153488 1467.0139415405017 1381.5582057887095 1128.5752152090795 952.516158814719 1.1339346701462294 1.3271839838888668 1.3993994111925876 1.20575450197001 1.3137405820751327 1.5372144434141461 1.540145989088529 1.4504302032081817 1.184835768679707 1.0 9.89559975696769 -6.535452397363331 24.95169672644867 1.387745027002144 1.2778059873113914 0.007385572714830424 0.16856111170777194 594.9513196189656 1180638.850427953 0.05470020314644251 0.05473341930762613 2.914389560944195e-07 6.535452397363331 -0.1099390396907527 NVPESSPHS(ph)PCEGLPSEAALTPRPEGK ddPTM_A459_Selumetinib_30min_R2 2 NVPESSPHSPCEGLPSEAALTPRPEGK 27 1 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2;H0YCW2;S4R3B3;H7C453;S4R3U7 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 NVPES(0.008)S(0.008)PHS(0.978)PCEGLPS(0.006)EAALTPRPEGK;NVPES(0.008)S(0.008)PHS(0.985)PCEGLPSEAALTPRPEGK 82.21600000000002 3.712e-05 17829100.0 45246.0 37136.0 49274.0 58412.0 59254.0 47961.0 44749.0 48511.0 41265.0 57448.0 True False 42731.408454088865 39984.211788939676 46103.76448547483 50456.184833679676 51809.98278251895 54567.19240339006 46829.91716846132 48652.15897857162 49519.153040434416 55789.32697217049 0.7659423544471985 0.7167000205771452 0.8263904045387188 0.904405691412066 0.9286719448751091 0.9780937567253666 0.8394063830850941 0.872069293878395 0.8876097943453621 1.0 15.767701526745283 -5.5468132842445 2.760973611070785 0.9108052470781254 0.7417332578412229 0.6959410904476473 0.046349809210253834 0.15327786702549193 2.3485136070090613 0.013393605395046219 0.028881831420466707 2.8391393942074634e-06 5.5468132842445 -0.16907198923690248 NVPHEDICEDS(ph)DIDGDYR ddPTM_A459_Selumetinib_30min_R1 4 NVPHEDICEDSDIDGDYR 18 0 O00629 O00629 KPNA4 Importin subunit alpha-3 1 NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR 224.12 7.2778e-15 51368900.0 12205.3 14992.3 11162.0 12389.400000000001 12456.3 12735.3 14174.3 11632.6 6992.2300000000005 11889.2 True False 12489.659742620413 13236.994546268828 9646.261708477203 10225.823867841502 11329.629864338389 12607.194444727229 13105.121139205601 11324.065659989958 11865.30361772653 13415.294630614995 0.9310015237472166 0.9867091935544026 0.7190495605264982 0.7622511580554621 0.8445308266642971 0.9397627701710253 0.9768791144771768 0.8441160609434062 0.8844609040973848 1.0 13.711591119385263 -6.753215410345862 24.322156273989606 0.9222907338737548 0.8443686825262642 0.19075514255570303 0.0819027095141243 260.28256187359455 769776.047203219 0.029788563028723212 0.02928183782881962 1.7651620819783948e-07 6.753215410345862 -0.07792205134749064 NVPHEDICEDS(ph)DIDGDYR ddPTM_A459_Selumetinib_30min_R2 5 NVPHEDICEDSDIDGDYR 18 0 O00629 O00629 KPNA4 Importin subunit alpha-3 1 NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR;NVPHEDICEDS(1)DIDGDYR 139.25 0.00021696 226583300.0 238397.0 219721.0 243985.0 256093.0 265200.0 234769.0 227034.0 202028.0 200048.0 245759.0 True False 225147.84911880412 236572.89418563183 228287.27073078236 221212.69161493392 231883.20508191877 267106.2987292068 237591.53085933655 202615.8680324639 240063.18980813812 238663.29911143435 0.9433702205452221 0.9912411965577226 0.9565244073165715 0.9268818977971449 0.9715913839507017 1.1191762609654201 0.9955092875356701 0.8489611464637489 1.0058655465750943 1.0 17.86461720482456 -4.743605293693046 21.858154274196533 0.9770592986860238 0.9433697070541314 0.026336158505460228 0.06439978677908449 1200.9073201707297 1471477.249561548 0.01691598995000714 0.4129055901668701 1.8046571491341822e-05 4.743605293693046 -0.033689591631892446 NVPHEDICEDSDIDGDYR ddPTM_A459_Selumetinib_30min_R2 2 NVPHEDICEDSDIDGDYR 18 0 O00629 O00629 KPNA4 Importin subunit alpha-3 0 ; 176.44 3.1722e-09 20416600.0 134444.0 118160.0 125012.0 136905.0 157265.0 117996.0 106363.0 124424.0 92045.0 137191.0 False True 126972.14070197401 127222.49205571745 116968.86402277443 118258.30282570227 137507.9647330616 134248.87793895902 111309.09025428616 124786.05324049793 110456.57195218191 133229.93936497427 0.9530300869847471 0.9549091792888996 0.8779472885771288 0.8876255846798952 1.032110090183018 1.0076479699596157 0.8354660430292815 0.9366217070673215 0.8290671937453467 1.0 17.02355879498274 -10.840064773689631 5.273596422430152 1.0000186119765087 0.9257530380392937 0.11241445109167902 0.06400768288979838 1.44444066735626e-05 1.8702225553421565e-06 0.06391223825227103 0.015497110715927402 1.4452242039144592e-11 10.840064773689631 -0.074265573937215 NVPNWHR ddPTM_A459_Selumetinib_30min_R1 2 NVPNWHR 7 0 F5H018;B5MDF5;J3KQE5;P62826;B4DV51 F5H018 RAN GTP-binding nuclear protein Ran 0 ; 107.66 0.023326 29682000.0 9386.8 13160.4 10931.9 12056.5 9394.4 10404.2 9715.6 8513.5 5594.1 8259.3 False True 9605.494176466715 11619.574249896023 9447.408024628381 9951.058603534557 8544.678178716027 10299.543194257772 8982.744469925561 8287.694324254631 9492.779123101498 9319.461607394818 1.0306919628109132 1.2468074594219165 1.0137289494418904 1.0677718330465118 0.9168639282698461 1.1051650436636038 0.9638694646048996 0.8892889603921433 1.0185973742913599 1.0 13.186030896325178 -5.633462698379693 1.9786956201567083 0.9850761213142689 1.1353737027501825 0.3157089796094793 0.07939874908111574 0.3581597966686945 2.815959727441877 0.022903221297492185 0.05222686438635566 2.3256122244895775e-06 5.633462698379693 0.15029758143591354 NVPNWHR ddPTM_A459_Selumetinib_30min_R2 4 NVPNWHR 7 0 F5H018;B5MDF5;J3KQE5;P62826;B4DV51 F5H018 RAN GTP-binding nuclear protein Ran 0 ;;; 124.89 0.008772799999999999 47226700.0 187002.0 199304.0 224468.0 222430.0 242245.0 151137.5 168462.5 172300.5 140654.5 207343.0 False True 176609.17746831803 214589.97593663406 210025.97326227967 192134.65028684773 211812.01740222267 171955.31873537568 176296.34005211105 172801.86592911684 168789.33021509257 201356.46884818893 0.8770971127899103 1.0657217876542244 1.0430555048153285 0.9542015281947861 1.051925565708627 0.8539845763039279 0.8755434630959298 0.8581887977952146 0.8382612745476279 1.0 17.619392295989364 -6.769267526954604 24.999976151592207 0.875729144845266 1.002165742379581 0.41871040130914283 0.06614963406927124 153.74022258407976 490982.0331547273 0.02201988997977917 0.019776778709847176 1.7011102955486392e-07 6.769267526954604 0.1264365975343149 NVPQEESLEDS(ph)DVDADFK ddPTM_A459_Selumetinib_30min_R1 5 NVPQEESLEDSDVDADFK 18 0 O00505 O00505 KPNA3 Importin subunit alpha-4 1 NVPQEESLEDS(1)DVDADFK;NVPQEES(0.005)LEDS(0.995)DVDADFK;NVPQEESLEDS(1)DVDADFK;NVPQEESLEDS(1)DVDADFK;NVPQEES(0.008)LEDS(0.992)DVDADFK 250.64 5.5618e-33 66550900.0 38010.3 42862.0 39155.2 41920.7 32955.0 37301.7 37395.600000000006 36334.8 22070.8 33971.6 True False 38895.86603483113 37843.69711399681 33838.13890411813 34600.03669399836 29974.226068677825 36926.47876523374 34574.81978462973 35371.08307193603 37452.53561254686 38332.18577140603 1.0147051427431404 0.9872564361364018 0.8827604850376093 0.9026366745777467 0.7819597412844941 0.9633282846286089 0.901978822465712 0.9227515300815734 0.9770519175685685 1.0 15.226268645145744 -9.99069460165002 11.398927808938353 0.9999999753144181 0.9219399728759915 0.10769548115101257 0.06286744538355092 0.0 0.0 0.06355968593043676 0.015415488154251502 1.0216576666453862e-10 9.99069460165002 -0.07806000243842659 NVPQEESLEDS(ph)DVDADFK ddPTM_A459_Selumetinib_30min_R2 4 NVPQEESLEDSDVDADFK 18 0 O00505 O00505 KPNA3 Importin subunit alpha-4 1 NVPQEES(0.003)LEDS(0.997)DVDADFK;NVPQEES(0.001)LEDS(0.999)DVDADFK;NVPQEES(0.014)LEDS(0.986)DVDADFK;NVPQEES(0.127)LEDS(0.873)DVDADFK 184.8 3.4407e-10 63810000.0 327751.0 292146.0 315764.0 322646.0 309503.0 237406.0 279942.0 267818.0 211372.0 297968.0 True False 309535.9115112072 314552.6588025525 295448.08801784774 278701.05820460536 270620.466148074 270106.5215429041 292959.8576945493 268597.30604034354 253652.30622713428 289364.88962616096 1.0697079106974787 1.08704500815193 1.021022586394451 0.9631474591290861 0.9352221912537371 0.9334460787273213 1.0124236498527268 0.9282304649584555 0.8765828727695166 1.0 18.14253035610207 -5.596354263328675 2.193924153805322 0.9465559031618769 1.0794397977210337 0.6769217672770822 0.036127973951532964 0.18003885309975567 1.7340086216619834 0.01077259533124476 0.02430664050645986 2.5330615148810653e-06 5.596354263328675 0.13288389455915683 NVS(ph)PEFVPCEGEGGFGLHK ddPTM_A459_Selumetinib_30min_R1 3 NVSPEFVPCEGEGGFGLHK 19 0 O94986-3;O94986 O94986-3 CEP152 Centrosomal protein of 152 kDa 1 NVS(1)PEFVPCEGEGGFGLHK;NVS(1)PEFVPCEGEGGFGLHK;NVS(1)PEFVPCEGEGGFGLHK 155.91 2.2423e-06 35766500.0 11002.0 12947.0 13423.1 14275.7 12603.6 11349.3 11743.2 11332.599999999999 6497.700000000001 9277.8 True False 11258.32519383463 11431.159221102991 11600.31674781046 11782.716983077864 11463.606605346304 11235.136346339914 10857.400969495437 11032.022634527286 11026.122326768664 10468.696003424944 1.0754276549965105 1.0919372591737468 1.1080956734263079 1.1255190693495183 1.0950367267896464 1.073212589482417 1.0371302181229949 1.0538105826091466 1.0532469682146994 1.0 13.353794128737542 -7.015124743365865 2.3007541363302852 1.0399471728750262 1.1010948785644459 0.7203385508343967 0.018461169388822706 0.17793881514634494 1.8844612736871453 0.00807970960001162 0.006313903138764031 9.657734379032537e-08 7.015124743365865 0.06114770568941963 NVS(ph)PEFVPCEGEGGFGLHK ddPTM_A459_Selumetinib_30min_R2 2 NVSPEFVPCEGEGGFGLHK 19 0 O94986-3;O94986 O94986-3 CEP152 Centrosomal protein of 152 kDa 1 NVS(1)PEFVPCEGEGGFGLHK;NVS(1)PEFVPCEGEGGFGLHK 147.78 2.6162e-05 16084200.0 88531.0 86517.0 87112.0 101724.0 97590.0 74988.0 72372.0 75680.0 63700.0 89365.0 True False 83610.80143767278 93152.57570399847 81507.3087603743 87869.01571631199 85329.87173433063 85316.91632671161 75737.44140239735 75900.21627050157 76441.7799267097 86784.80025184526 0.9634267889657903 1.0733743170886405 0.9391887579834726 1.0124931492763756 0.9832352149997178 0.983085933010459 0.8727039894383692 0.8745796043805233 0.8808199097639147 1.0 16.405154766441626 -7.187075033911053 5.4857631106563325 0.8967515293357965 0.9951144317534675 0.4292304515119616 0.04771251025267764 0.18217152706754175 9.905888442252865 0.01757245289278921 0.013458488392700316 6.500173758616231e-08 7.187075033911053 0.09836290241767098 NVS(ph)PSQR ddPTM_A459_Selumetinib_30min_R2 1 NVSPSQR 7 0 D6REZ3;Q14094-2 D6REZ3 CCNI 1 NVS(1)PSQR 98.582 0.021764 10986000.0 5489.0 4090.2 4508.4 4621.5 5153.9 3737.2 3878.8 4829.9 3915.5 3414.3 True False 5183.943354207969 4403.905187934109 4218.334452374775 3992.043727467822 4506.421005549405 4251.96537707615 4059.171885696387 4843.954209367011 4698.7094082108515 3315.7202875832368 1.5634441100538197 1.3281895956139378 1.2722226504363658 1.2039748173020783 1.3591077095450794 1.2823655219045402 1.2242202398366473 1.460905561758852 1.4171006600908571 1.0 11.695106591635298 -4.763026667133781 3.750702992342383 1.2927450780339746 1.5973745381635687 0.3261233207671034 0.1212312129671723 0.3396108360160629 8.274057330022288 0.02955295430654635 0.29660838509004134 1.7257319230246534e-05 4.763026667133781 0.304629460129594 NVS(ph)TGSAENEEK ddPTM_A459_Selumetinib_30min_R1 1 NVSTGSAENEEK 12 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 NVS(0.343)T(0.343)GS(0.315)AENEEK 169.3 1.0548e-05 0.0 1980.5 2108.2 1401.2 1476.9 1416.4 1218.3 1783.0 1995.7 972.46 1839.1 True False 2026.6417966178385 1861.3709639244087 1210.9247362406618 1218.9871398465705 1288.2868700857312 1206.0450081278946 1648.5068744984637 1942.7675530527945 1650.193594331756 2075.1663993510106 0.9766165244636056 0.8969743170988772 0.5835313913233018 0.5874165754745246 0.6208113578210553 0.5811799036959514 0.7943974396530414 0.9361984434888583 0.795210251499754 1.0 11.019011309744966 -7.537332258053286 5.613850275065604 0.895228730812185 0.6999405342681982 0.30568453940590856 0.13591522038812587 0.23880250658751748 25.002754693192266 0.07020093907324855 0.041466325580921656 2.9018017744984573e-08 7.537332258053286 -0.19528819654398677 NVSEELDRT(ph)PPEVSK ddPTM_A459_Selumetinib_30min_R2 1 NVSEELDRTPPEVSK 15 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 NVS(0.001)EELDRT(0.999)PPEVSK 80.733 0.039621 20551000.0 121820.0 104380.0 109080.0 113900.0 110920.0 94956.0 93604.0 98579.0 89078.0 111810.0 True False 115049.73208409808 112385.61036540054 102061.91155732442 98386.62351154075 96985.23796261853 108035.32707525493 97956.7714728072 98865.84856936804 106896.08904727534 108581.75478273173 1.0595678096592613 1.035032180040562 0.9399545233133016 0.9061064053386217 0.8932001343750852 0.9949675918521469 0.9021476183435722 0.9105199005780955 0.9844756079064171 1.0 16.7284221789065 -5.222128989357846 3.829936757700285 0.9352398033021655 1.0534318387141677 0.5508671667785 0.03818323433423912 0.15110262178632058 4.769549500097704 0.009754674779881551 0.027903033198497264 5.996129593766824e-06 5.222128989357846 0.11819203541200218 NVSGIS(ph)FTENMGSSQQK ddPTM_A459_Selumetinib_30min_R2 1 NVSGISFTENMGSSQQK 17 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 NVSGIS(1)FTENMGSSQQK 156.83 0.00020775 0.0 11583.0 11159.0 10827.0 11617.0 14732.0 7743.4 8830.1 11662.0 8243.5 11248.0 True False 10939.263230422817 12014.859418159678 10130.402607546292 10034.744559557226 12881.234454248985 8809.983062413423 9240.71714651121 11695.934489251971 9892.430342634703 10923.24101418628 1.0014668005783016 1.099935394866385 0.9274172925773303 0.9186599972045713 1.1792502277959271 0.8065356290291208 0.8459684387179651 1.0707384808283709 0.9056314265873253 1.0 13.415113358641667 -6.77858137204087 24.999974083574255 0.9252081186153758 1.018122396862389 0.1992239383875718 0.09928316075150624 460.49842069097633 671589.1366761805 0.03560043893280173 0.031471591799671635 1.6650168309331728e-07 6.77858137204087 0.09291427824701315 NVSS(ph)FPDDATSPLQENR ddPTM_A459_Selumetinib_30min_R1 4 NVSSFPDDATSPLQENR 17 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 NVS(0.006)S(0.994)FPDDATSPLQENR;NVS(0.001)S(0.999)FPDDATSPLQENR;NVS(0.026)S(0.974)FPDDATSPLQENR;NVS(0.001)S(0.999)FPDDATSPLQENR 232.01 1.504e-16 42797500.0 5464.049999999999 5894.209999999999 6589.7 6526.200000000001 5474.610000000001 5483.099999999999 4928.74 5210.75 2937.7000000000003 4582.7300000000005 True False 5591.351733809498 5204.113153056113 5694.854934631089 5386.521681946435 4979.432492120897 5427.944992256467 4556.961173648658 5072.543983098589 4985.062338881188 5170.968035070339 1.0812969053159966 1.0064098477811076 1.1013131189378207 1.0416853566709707 0.9629594417040644 1.0496961024402527 0.88125881706145 0.9809660297058069 0.9640481830619898 1.0 12.336218671326739 -6.380211877256211 1.4333236800374267 0.9636935405525144 1.0602582412333128 0.4381360093826423 0.04606288748712804 0.3802269789608524 1.5795263305923575 0.017705770238212667 0.022174777716449 4.166660569189741e-07 6.380211877256211 0.09656470068079837 NVSS(ph)FPDDATSPLQENR ddPTM_A459_Selumetinib_30min_R2 2 NVSSFPDDATSPLQENR 17 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 NVS(0.004)S(0.996)FPDDATSPLQENR;NVS(0.126)S(0.874)FPDDATSPLQENR 197.1 8.1903e-08 23391000.0 71330.0 71062.0 81236.0 92873.0 98415.0 75811.0 73665.0 76196.0 73176.0 89426.0 True False 67365.76415661404 76512.22689965618 76009.36420306902 80223.53718513873 86051.22785873702 86253.27710626129 77090.56846442822 76417.71774507323 87813.24470827146 86844.03902334838 0.77570970804919 0.8810302671330792 0.8752398559287828 0.9237656157789979 0.9908708626000432 0.9931974384916821 0.8876898095873005 0.8799420041314293 1.0111603017987512 1.0 16.40613920526583 -4.210949407575749 0.7285988347976007 0.9525422686074188 0.49623454637368836 0.599516203538756 0.0456612150546028 4.587098946415737 1.0245546156514602 0.01912996691011572 2.0793424639422398 6.152485409062855e-05 4.210949407575749 -0.4563077222337304 NVSS(ph)YEK ddPTM_A459_Selumetinib_30min_R1 1 NVSSYEK 7 0 A0A0U1RR22;Q9UNF0 A0A0U1RR22 PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2 1 NVS(0.007)S(0.993)YEK 92.051 0.02753 11608000.0 3420.5 3750.1 4181.6 4175.3 4309.5 3531.0 3454.9 3307.9 2089.0 3140.3 True False 3500.1909948656003 3311.0365486258097 3613.761687884634 3446.162235087946 3919.706485904023 3495.4813458914855 3194.2941114440528 3220.1637464264873 3544.880425476664 3543.388094112325 0.9878090973668674 0.9344267296397509 1.0198605379662593 0.9725613293147514 1.1062029847695731 0.9864799601543954 0.901480172818686 0.9087809917793354 1.0004211594453396 1.0 11.79091377179152 -7.014928535859227 24.958732549365138 0.9449134285395848 1.0041056728771083 0.17869828734462012 0.051083750076504224 1072.2609478491763 1792689.654177569 0.019551164485300622 0.015691796822168827 9.662098579300907e-08 7.014928535859227 0.05919224433752346 NVSS(ph)YEK ddPTM_A459_Selumetinib_30min_R2 2 NVSSYEK 7 0 A0A0U1RR22;Q9UNF0 A0A0U1RR22 PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2 1 NVS(0.084)S(0.916)YEK;NVS(0.398)S(0.602)YEK 117.02 0.011896 37455000.0 390160.0 376990.0 368740.0 405290.0 398890.0 295970.0 317480.0 320250.0 237682.0 357020.0 True False 368476.4691342289 405903.9207860929 345015.66985375644 350088.8028357537 348777.87207815476 336737.1809518432 332243.4490746851 321181.87447975844 285225.0413899552 346711.90495063906 1.062774204960422 1.1707239208987672 0.9951076525707299 1.0097397805985215 1.0059587429736796 0.9712305119715576 0.9582695152102902 0.9263652902991165 0.8226571897799769 1.0 18.403377849248038 -5.899467762518682 0.5751737717316449 0.9151185881364975 1.140324598169652 0.5723199649756758 0.05552517417410645 0.9358093424244787 0.5375672853032686 0.03707284598723336 0.121648383512825 1.2604691984756273e-06 5.899467762518682 0.22520601003315444 NVSSFPDDAT(ph)SPLQENR ddPTM_A459_Selumetinib_30min_R1 4 NVSSFPDDATSPLQENR 17 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 NVSSFPDDAT(0.99)S(0.01)PLQENR;NVSSFPDDAT(0.967)S(0.033)PLQENR;NVSSFPDDAT(0.5)S(0.5)PLQENR;NVSSFPDDAT(0.5)S(0.5)PLQENR 252.79 2.1277e-30 488832800.0 12557.4 15699.599999999999 16665.5 16948.6 14740.3 12500.56 14850.1 13716.5 8197.48 12404.0 True False 12849.962987553068 13861.483533453977 14402.416637038776 13988.84517462495 13407.04246761133 12374.815716000356 13729.945001115895 13352.693862528777 13910.524839749381 13996.174225191628 0.9181053894302416 0.9903766065232867 1.0290252468503824 0.9994763532913525 0.9579076576140413 0.8841570215471455 0.9809784288340346 0.9540245532593717 0.9938805144845878 1.0 13.77274490810349 -8.376547672040296 5.436536691358339 0.9993734082961727 0.9661901098982725 0.10047030974767468 0.038892861891830895 0.6341636694311472 24.574524420090444 0.04030902311710593 0.010492989394863435 4.20196400636691e-09 8.376547672040296 -0.03318329839790024 NVSSFPDDAT(ph)SPLQENR ddPTM_A459_Selumetinib_30min_R2 3 NVSSFPDDATSPLQENR 17 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 NVSSFPDDAT(0.5)S(0.5)PLQENR;NVS(0.053)S(0.007)FPDDAT(0.47)S(0.47)PLQENR;NVSSFPDDAT(0.908)S(0.092)PLQENR 289.58 2.4373e-75 225081700.0 63232.2 71153.0 70879.4 80345.0 90068.4 66666.5 69614.5 73270.9 60946.7 74049.4 True False 59718.007462552225 76610.20630704515 66319.09657165558 69401.87239714425 78753.2023702877 75849.20523676746 72851.71218851476 73484.10618834956 73137.74299307991 71911.4014185533 0.830438654852092 1.0653415841688707 0.9222334047650073 0.9651024876180262 1.095142088970181 1.0547591027366379 1.0130759622453813 1.021870033663264 1.0170535068199937 1.0 16.13393290495639 -4.75216041517757 24.993228160228245 1.0167474250057174 0.830438290105643 0.5892836200820846 0.04676794322046245 275.987781031435 743329.6386853271 0.012268693504506684 0.14932223586525722 1.7694552546221844e-05 4.75216041517757 -0.1863091349000744 NVSSFPDDATS(ph)PLQENR ddPTM_A459_Selumetinib_30min_R1 4 NVSSFPDDATSPLQENR 17 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 NVSSFPDDAT(0.421)S(0.579)PLQENR;NVSSFPDDAT(0.025)S(0.975)PLQENR;NVSSFPDDAT(0.107)S(0.893)PLQENR;NVSSFPDDAT(0.076)S(0.924)PLQENR 316.25 5.7294e-104 41533700.0 10198.85 11679.25 12193.91 13773.289999999999 11950.59 9730.45 11151.13 10490.07 5278.400000000001 8681.429999999998 True False 10436.463361492477 10311.837980463975 10538.043998353103 11368.043458174137 10869.661244548028 9632.570507541714 10309.991286273726 10211.839267050429 8957.059280917196 9795.776104789213 1.065404440633349 1.0526820815578315 1.0757742812436262 1.1605046232749474 1.1096273667620666 0.9833391866553884 1.0524935621214444 1.042473731311376 0.9143797474646278 1.0 13.257944084268175 -6.7594879967662385 24.99827905876401 1.0045641181209604 1.0933855279431506 0.5259276864283744 0.04456182810579356 47.9298102165104 614007.1618594915 0.015928604876884044 0.015175359797815716 1.7398507841824756e-07 6.7594879967662385 0.08882140982219022 NVSSFPDDATS(ph)PLQENR ddPTM_A459_Selumetinib_30min_R2 4 NVSSFPDDATSPLQENR 17 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 NVSSFPDDAT(0.081)S(0.919)PLQENR;NVSSFPDDATS(1)PLQENR;NVSSFPDDAT(0.412)S(0.588)PLQENR;NVSSFPDDAT(0.011)S(0.989)PLQENR 310.9 3.820499999999998e-103 352140200.0 141044.0 143676.0 158612.0 173053.0 176045.0 142556.0 150251.0 147371.0 123615.0 155044.0 True False 133205.33912386734 154695.48720884614 148407.0766036884 149482.88286692425 153928.6532377315 162191.79500547674 157237.9692167082 147799.82521141766 148341.45409168306 150567.47686730963 0.8846886585026393 1.0274163479884464 0.9856516140897736 0.9927966249886674 1.0223233890900885 1.077203380039444 1.0443023452885318 0.9816185293565687 0.9852157795166595 1.0 17.20005065062572 -4.757871795087545 24.992651499932236 1.0141712520352921 0.8846884751264823 0.6352835714686782 0.029141024090595456 72.43360568911497 507355.1581700144 0.00804757155674225 0.05753901835737505 1.7463376004461625e-05 4.757871795087545 -0.12948277690880983 NVST(ph)GSAENEEK ddPTM_A459_Selumetinib_30min_R2 2 NVSTGSAENEEK 12 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 NVS(0.096)T(0.9)GS(0.004)AENEEK;NVS(0.082)T(0.725)GS(0.193)AENEEK 172.43 0.00052658 15699900.0 50098.0 39829.0 37961.0 43509.0 39359.0 38966.0 58518.0 51088.0 39904.0 34712.0 True False 47313.75371818374 42883.7562295799 35518.63058881175 37582.99914278858 34414.37054607561 44333.21280187019 61239.20295121724 51236.6576219263 47885.915010917124 33709.77436739282 1.4035618631713518 1.2721460476775246 1.0536596953069084 1.1148991604981582 1.0209018360966646 1.3151441572612048 1.8166601260450264 1.5199347543389994 1.4205350201701963 1.0 15.040879350385875 -7.003569036655003 24.600753431368606 1.4945092018746664 1.168612795224027 0.24128564324160795 0.21407412338633514 138.82881668308355 956930.3049123815 0.07522872651851298 0.06494100637125651 9.918156649391548e-08 7.003569036655003 -0.32589640665063935 NVSTCEVSSSQAIS(ph)SPQR ddPTM_A459_Selumetinib_30min_R1 1 NVSTCEVSSSQAISSPQR 18 0 Q9H2X6-3;Q9H2X6 Q9H2X6-3 HIPK2 Homeodomain-interacting protein kinase 2 1 NVSTCEVSSSQAIS(0.691)S(0.309)PQR 205.65 1.1804e-29 0.0 539.37 985.81 768.96 1121.0 513.49 495.28 892.81 648.6 338.27 438.79 True False 551.9362715686768 870.3909069093646 664.5394555949322 925.2383937761564 467.04492016402287 490.2979328782593 825.4646228945452 631.3970210502796 574.0194837367118 495.11297067654294 1.1147683544110916 1.7579642595911522 1.3421976295367053 1.8687419812732278 0.9433098056910795 0.9902748704165351 1.6672247987496591 1.2752584934050757 1.1593707249324285 1.0 8.951613934440605 -8.557792633363363 0.2035318602074426 0.8698981896931909 1.558868586423611 0.14380039451906812 0.29786833070580737 8.10418310836354 1.2521476396653646 2.0190071220296155 1.2589496330960708 2.7682631183071765e-09 8.557792633363363 0.68897039673042 NVSTCEVSSSQAISS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 NVSTCEVSSSQAISSPQR 18 0 Q9H2X6-3;Q9H2X6 Q9H2X6-3 HIPK2 Homeodomain-interacting protein kinase 2 1 NVSTCEVSSSQAIS(0.116)S(0.884)PQR;NVSTCEVSSSQAIS(0.006)S(0.994)PQR 303.73 6.337599999999997e-96 10921600.0 58320.0 49607.0 62426.0 60975.0 58175.0 44885.0 51768.0 47725.0 39882.0 54699.0 True False 55078.80787345759 53411.697388354456 58409.57912428972 52670.09981225802 50866.53640890131 51067.50132453791 54175.31457634598 47863.87184870095 47859.51439618576 53119.69774493025 1.0368810481176791 1.0054970125173965 1.0995841769424288 0.9915361353366297 0.9575833178334682 0.9613665644287631 1.019872417883185 0.9010569314331063 0.9009749006102633 1.0 15.696959317214505 -5.978510682144122 7.076501423921349 0.9568499452518693 1.0438749731416248 0.4945301959385665 0.04089290138026262 0.1483093856763208 30.575140127229865 0.01205891521925141 0.017642487965961736 1.0507256103270954e-06 5.978510682144122 0.08702502788975552 NVSTGS(ph)AENEEK ddPTM_A459_Selumetinib_30min_R1 5 NVSTGSAENEEK 12 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 NVS(0.118)T(0.153)GS(0.729)AENEEK;NVS(0.045)T(0.172)GS(0.783)AENEEK;NVS(0.156)T(0.156)GS(0.688)AENEEK;NVS(0.001)T(0.153)GS(0.845)AENEEK;NVST(0.001)GS(0.998)AENEEK 196.67 0.000154 130572000.0 19814.6 20630.7 13903.2 13225.7 13169.4 13264.900000000001 17229.0 17876.2 10472.279999999999 16717.3 True False 20276.241627500047 18215.248053047777 12015.221804811 10916.079772136767 11978.230095246414 13131.467149565551 15929.402658852527 17402.06510591891 17770.694294930952 18863.12829529152 1.0749140497846934 0.9656536162983389 0.6369686733143916 0.5786993334961074 0.6350076142055575 0.6961447191579211 0.8444730062525584 0.9225439616112185 0.9420862762920796 1.0 14.203281334557484 -7.645407656167652 2.5729742537075158 0.9572619104416003 0.7541248395700796 0.2523743974928291 0.14596342412624308 0.45789414298430214 6.085080169816305 0.09739956560221358 0.047882740149709294 2.2625195671037274e-08 7.645407656167652 -0.20313707087152066 NVSTGS(ph)AENEEK ddPTM_A459_Selumetinib_30min_R2 2 NVSTGSAENEEK 12 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 NVS(0.001)T(0.023)GS(0.976)AENEEK;NVS(0.151)T(0.151)GS(0.697)AENEEK 146.27 0.00066081 120308000.0 69653.0 50601.0 58123.0 58315.0 59660.0 48534.0 69842.0 64190.0 46620.0 38638.0 True False 65781.96510305109 54481.933992140715 54383.42945953752 50372.39640101396 52164.9774328329 55219.11795221393 73089.79138929758 64376.78227277346 55945.302671635814 37522.42054641981 1.7531375680220516 1.4519834594556584 1.4493582414881414 1.3424612716201814 1.3902348695308306 1.4716299521215894 1.947896492948172 1.7156884160266668 1.490983306965089 1.0 15.195465277703294 -4.754018850086302 24.242513506860334 1.503061788706005 1.7531382189433713 0.10352170371999703 0.2326603843287242 487.8936431336604 1593723.3294216238 0.05937260964130599 0.5915137766064673 1.761899571390335e-05 4.754018850086302 0.25007643023736637 NVSTGS(ph)AENEEKSEVQAIIESTPELDMDKDLSGYK ddPTM_A459_Selumetinib_30min_R1 1 NVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYK 35 2 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 NVS(0.085)T(0.262)GS(0.614)AENEEKS(0.038)EVQAIIES(0.001)TPELDMDKDLSGYK 76.835 2.0158e-06 37735000.0 1618.6 2015.1 1922.3 2444.3 1829.7 2062.0 2112.6 1939.0 1076.5 1490.1 True False 1656.3102307526558 1779.1711552054246 1661.2622184380693 2017.4488901936309 1664.2039580597716 2041.2581521462039 1953.2448811359816 1887.5714212403518 1826.741875550804 1681.3688498031322 0.9850962987369425 1.0581682629684401 0.9880415107206149 1.1998847786610591 0.9897911206423442 1.2140454204234903 1.161699219873547 1.1226397000642443 1.0864611151590522 1.0 10.7154205347619 -5.740201342032317 24.998277316511313 1.1171558328271938 1.0152086173692276 0.2825322018515736 0.07254353312525975 297.53478203850096 350211.37766471354 0.018786345548549355 0.032497827726168146 1.8188574277842514e-06 5.740201342032317 -0.10194721545796614 NVTDSS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 NVTDSSR 7 0 Q9NU02 Q9NU02 ANKEF1 Ankyrin repeat and EF-hand domain-containing protein 1 1 NVTDSS(1)R 104.21 0.018138 6641000.0 564.37 916.24 827.24 733.36 712.65 526.29 651.44 623.66 325.98 457.57 True False 577.5187229271445 808.9661948515804 714.9053517040571 605.2924428721522 648.1909333285762 520.9960004330869 602.3013563226473 607.1185108668169 553.1642513627969 516.303566609234 1.1185642716356468 1.566842158702051 1.3846608815800325 1.1723576632393664 1.2554453915271158 1.0090885171579773 1.166564392104037 1.1758944739700325 1.0713934342844875 1.0 9.012075754001602 -6.054576904307873 1.6843467878868978 1.1098460617423211 1.3748556984620275 0.4259868178154388 0.12522833109217255 0.33812710161871856 1.9219262532354047 0.04130476872596731 0.06576231663679155 8.819076212424632e-07 6.054576904307873 0.26500963671970634 NVTELNEPLSNEER ddPTM_A459_Selumetinib_30min_R1 2 NVTELNEPLSNEER 14 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 ; 183.89 0.0010747 19006800.0 4366.6 4577.9 5427.299999999999 6258.4 5581.5 5313.0 4826.1 4765.1 3455.2 4412.2 False True 4468.333284075465 4041.9173397920304 4690.302470024935 5165.4879247178405 5076.654310493864 5259.556043818027 4462.063391484599 4638.714068773798 5863.222042176627 4978.548848467475 0.8975172123601703 0.8118665624896371 0.9421023299728656 1.0375489087162235 1.0197056341139623 1.0564435950923838 0.8962578308050823 0.9317401937718686 1.177696999795729 1.0 12.281509570287263 -5.501450987334201 4.211842697014117 1.0103742782199985 0.8564241640769089 0.43628684457016353 0.07355684072783569 0.1965159244516288 8.082457684161406 0.020112684762339707 0.041054156721304 3.1517300512566833e-06 5.501450987334201 -0.15395011414308957 NVTELNEPLSNEER ddPTM_A459_Selumetinib_30min_R2 1 NVTELNEPLSNEER 14 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 194.98 0.0016994 10796000.0 24466.0 27736.0 24681.0 29022.0 26623.0 14134.0 19662.0 22108.0 18389.0 21608.0 False True 23106.277665157973 29863.26201470355 23093.051330640967 25069.153534257523 23278.380727360203 16080.830204322574 20576.32195951388 22172.330619823577 22067.313831589683 20984.120895673655 1.1011315546662643 1.4231361972786063 1.1005012526115456 1.1946725649786971 1.1093331401917133 0.7663332804967777 0.980566308296296 1.0566242317253756 1.0516196480806281 1.0 14.3570104040781 -6.529252286909916 24.855783727725175 0.9710159396491747 1.2053730140890906 0.49299336938092786 0.11227274180368796 131.38996487389693 512394.58801463986 0.03757066020795213 0.037663916882429774 2.9562946203901594e-07 6.529252286909916 0.23435707443991594 NVVHELR ddPTM_A459_Selumetinib_30min_R2 2 NVVHELR 7 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 ; 101.28 0.028132 4108000.0 33017.0 25587.0 34152.0 39034.0 37063.0 28618.0 29907.0 30795.0 25353.0 35999.0 False True 31182.047317523124 27549.440624827643 31954.697501886094 33717.50186259419 32406.814592576022 32559.869731661493 31297.734759596246 30884.6083516133 30424.30842200734 34959.61533336525 0.8919448060334682 0.7880361486281751 0.9140460270278982 0.9644700475412384 0.9269785803863566 0.9313566359692336 0.8952539798035442 0.8834367328446322 0.8702701140126837 1.0 15.09340169025468 -5.3710546565995685 7.959984941147836 0.9203113376985951 0.84032373168656 0.37548442241601643 0.042859226409945224 0.2777548987536035 17.91931381437058 0.011104607381414267 0.02321971537070693 4.255448543175232e-06 5.3710546565995685 -0.07998760601203503 NVYATTVGT(ph)PYK ddPTM_A459_Selumetinib_30min_R1 1 NVYATTVGTPYK 12 0 Q13439-3;Q13439-4;Q13439;Q13439-5;H0Y6I0 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 NVYAT(0.014)T(0.014)VGT(0.971)PYK 114.7 0.010454 0.0 1747.3 1828.5 1787.7 1642.5 1328.4 1602.2 1881.0 1673.4 1299.1 1834.0 True False 1788.0086903460501 1614.4183699534126 1544.9401591331941 1355.668208543566 1208.2464545480689 1586.083322681205 1739.1146555982125 1629.01599603074 2204.47781749006 2069.411764672803 0.8640178435579513 0.7801339479717657 0.7465600541695316 0.6550983384198128 0.5838598558170979 0.7664416283687177 0.8403908227868733 0.7871879457920765 1.0652678481503715 1.0 11.015005021085923 -8.074134194370156 1.6233434457733442 1.0370041756085049 0.7326912070268142 0.6406938919397328 0.08209212945623079 0.25826103429739794 1.2157776135883267 0.07963702622500379 0.025540574432476967 8.430742126765024e-09 8.074134194370156 -0.30431296858169066 NVYSS(ph)SR ddPTM_A459_Selumetinib_30min_R2 2 NVYSSSR 7 0 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 NVYS(0.034)S(0.965)SR;NVYS(0.087)S(0.91)S(0.003)R 96.034 0.023406 75826000.0 190438.0 142105.0 194099.0 196704.0 201987.0 162415.0 161496.0 166812.0 154157.0 157767.0 True False 179854.21834371585 153003.9965604071 181610.88165901275 169912.57586667343 176611.58727330886 184786.1919934238 169005.88399825318 167297.39530278684 184992.70750646378 153211.8567821062 1.1738922960740545 0.9986433150405931 1.1853578794315827 1.1090040903839353 1.1527279349174728 1.2060828442032512 1.1030861941619103 1.0919350422122533 1.207430752370265 1.0 17.225168423519776 -4.423542796698978 23.434278909650526 1.1230451083689443 11.991553574037527 0.04827611907211049 0.07138585549742502 3913.4642887194236 934562.3791579694 0.01629146337430245 28051.252172380977 3.771005825421734e-05 4.423542796698978 10.868508465668583 NVYSS(ph)SRYDDYDR ddPTM_A459_Selumetinib_30min_R1 1 NVYSSSRYDDYDR 13 1 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 NVYS(0.003)S(0.498)S(0.498)RY(0.001)DDYDR 135.86 0.0053403 14194000.0 3489.2 2926.1 5781.6 7212.8 4466.6 4254.9 3700.6 3644.5 2457.7 2097.7 True False 3570.491571198672 2583.5108516930154 4996.490476055529 5953.2198810246755 4062.5968186422815 4212.099569140097 3421.4607626298466 3547.8360209955977 4170.537396694113 2366.960228328322 1.5084712993763947 1.0914889150958118 2.1109313186830887 2.5151330426997363 1.7163773053810505 1.7795396469821185 1.445508345125964 1.4988997189451194 1.761980343725326 1.0 11.20881974955356 -7.240340960430071 6.278866384155677 1.4675616744485958 1.8010585719927035 0.16758904559898147 0.3885047631521895 0.39263160426604127 62.80580034437262 0.16732814479339003 0.12472620684068755 5.749883422591919e-08 7.240340960430071 0.3334968975441077 NWGS(ph)LLRMY(ph)GRES(ph)S(ph)K ddPTM_A459_Selumetinib_30min_R1 1 NWGSLLRMYGRESSK 15 2 Q8WYQ5-3;Q8WYQ5 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 4 NWGS(1)LLRMY(1)GRES(1)S(1)K 60.158 0.034122 2691400.0 1214.6 1463.9 1682.5 1726.6 1635.3 1377.5 1448.8 1530.5 1021.9 1383.1 True False 1242.8978167998116 1292.5059074513529 1454.0257413109578 1425.0817222960868 1487.3874037356652 1363.643600669929 1339.515849564429 1489.9061682353579 1734.0896633770246 1560.6343575348712 0.7964055198445418 0.8281926520526912 0.9316889214253177 0.9131426047463808 0.9530659097401235 0.8737752017864693 0.8583149814030019 0.9546798460779542 1.1111441030403417 1.0 10.607916851214409 -1.522878745342184 0.1577316921083364 1.0421048321792095 0.15380944777649935 0.5119500326426409 0.060509126042035254 61.275474435916855 0.6279727717528162 0.20403462535100683 12.597569671216705 0.029999999995727805 1.522878745342184 -0.8882953844027102 NWTEDMEGGIS(ph)SPVK ddPTM_A459_Selumetinib_30min_R1 1 NWTEDMEGGISSPVK 15 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.762)S(0.238)PVK 217.39 3.2184e-09 45814000.0 12552.0 15508.0 15751.0 16808.0 13771.0 13578.0 14073.0 12832.0 8067.3 11452.0 True False 12844.437178059647 13692.316150526402 13612.100714049853 13872.798325236081 12525.415481467528 13441.417647837603 13011.462279762698 12491.653675789676 13689.618887720395 12921.975751926364 0.9939994800055898 1.0596147534548033 1.053407077630571 1.0735818261513121 0.9693111736106053 1.0401983338990404 1.0069251428383925 0.9666984303021512 1.05940601890385 1.0 13.657539052490222 -6.251593870749284 24.98480740189759 1.007071959524218 1.0467736582335527 0.24546282631215932 0.03264174132525141 959.9993409770692 2436172.8734601676 0.009367877666322131 0.01194151533191081 5.602813020559935e-07 6.251593870749284 0.03970169870933482 NWTEDMEGGIS(ph)SPVK ddPTM_A459_Selumetinib_30min_R2 3 NWTEDMEGGISSPVK 15 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.5)S(0.5)PVK;NWTEDMEGGIS(0.981)S(0.019)PVK;NWTEDMEGGIS(0.868)S(0.132)PVK 134.02 0.00048692 22893500.0 146834.0 132264.0 144794.0 156666.0 160133.0 122567.0 138863.0 138970.0 106294.0 152634.0 True False 138673.55410307396 142408.22350420957 135478.11167978696 135327.82053607557 140015.6609328165 139449.49169755232 145320.40465181452 139374.37969227807 127555.7701025066 148227.0598292415 0.935548166865259 0.9607437647907523 0.913990413328434 0.9129764881795136 0.9446025651059625 0.9407829572967243 0.9803905226159415 0.9402762211760675 0.8605430766113262 1.0 17.177449319636672 NWTEDMEGGIS(ph)SPVKK ddPTM_A459_Selumetinib_30min_R2 1 NWTEDMEGGISSPVKK 16 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.591)S(0.409)PVKK 78.67399999999998 0.018437 31471000.0 127520.0 129590.0 125560.0 133980.0 139180.0 95475.0 115920.0 122410.0 88550.0 122960.0 True False 120432.94890300611 139529.13630247462 117481.60629939161 115731.6928716086 121694.96411501327 108625.81461424218 121310.50969112235 122766.1928339335 106262.47429372245 119409.82531155276 1.0085681692338457 1.1684895772892094 0.9838520908381683 0.9691974054032193 1.0191369411813336 0.9096890840500439 1.0159173198236453 1.028107967779231 0.8898972426805961 1.0 16.865562024147266 -5.370550130371206 8.743686433750574 0.9778329250962642 1.0882431329572015 0.3880769971974364 0.056058235920323544 0.28130225641430034 20.327420042152433 0.01376718862426278 0.0287344888643757 4.260395032408164e-06 5.370550130371206 0.11041020786093736 NWTEDMEGGISS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 NWTEDMEGGISSPVK 15 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.206)S(0.794)PVK 213.51 5.227300000000001e-07 53411000.0 2735.0 3632.6 3237.9 3415.0 2887.7 2640.3 2337.0 2501.0 1260.4 2196.3 True False 2798.720178616406 3207.293503250077 2798.2109645115893 2818.634357489364 2626.508044864842 2613.7409792005924 2160.718208470505 2434.6653556070764 2138.806744026228 2478.2164987736523 1.1293283617477954 1.2941942339731856 1.1291228857108677 1.1373640514798316 1.0598380109907959 1.0546862957671392 0.8718843610070945 0.9824264170672227 0.8630427345974891 1.0 11.275086512521357 -6.549812542829716 0.9585230264102645 0.9241531117059831 1.2030775247609506 0.7450448131363334 0.06258535222288959 0.25165811437635244 0.5020902218633589 0.03173746616457222 0.03639962749753488 2.8195997096252257e-07 6.549812542829716 0.2789244130549675 NWTEDMEGGISS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 NWTEDMEGGISSPVK 15 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.236)S(0.764)PVK;NWTEDMEGGIS(0.088)S(0.912)PVK 121.95 0.0020146 16704800.0 79899.0 72190.0 79711.0 78149.0 85954.0 68674.0 75136.0 78796.0 56692.0 74960.0 True False 75458.53344103888 77726.74087256468 74582.48104277463 67504.97138545549 75155.69008149038 78133.22013949689 78629.9728791596 79025.28331461994 68031.9841068292 72795.71003053036 1.0365794002062996 1.0677379318089797 1.024545004252241 0.9273207357568742 1.0324192187969627 1.0733217672679884 1.080145696033219 1.0855761044363317 0.934560348107007 1.0 16.151565812115685 -5.290262996881909 19.608596284076917 1.0240160201780844 1.052158580792463 0.052239088758001095 0.05277937787177978 173.49587747148502 118029.02134062217 0.014708827752118611 0.03065281944124461 5.125509031572913e-06 5.290262996881909 0.028142560614378587 NWTEDMEGGISS(ph)PVKK ddPTM_A459_Selumetinib_30min_R1 2 NWTEDMEGGISSPVKK 16 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.058)S(0.942)PVKK;NWTEDMEGGIS(0.087)S(0.913)PVKK 245.96 1.8312e-22 72786000.0 7825.1 9078.8 9677.0 10945.2 7951.0 8117.7 8084.599999999999 7318.9 3917.6000000000004 6409.6 True False 8007.409605005936 8015.849875380391 8362.916551956097 9033.82628684995 7231.833453863064 8036.043308281875 7474.772113051197 7124.778996862303 6647.881069816845 7232.334594791061 1.1071680243849762 1.1083350431759118 1.1563232373097498 1.249088543740271 0.999930708276639 1.1111271475284992 1.0335213360336988 0.9851285091253628 0.9191888155457912 1.0 12.820245708416214 -7.256669636128504 1.0146623877626102 0.9569818745987907 1.140989693472442 0.594902752041371 0.0587017227247099 0.3832471693497123 0.7678779882728916 0.04336576945180756 0.02479550490364688 5.537711977614036e-08 7.256669636128504 0.18400781887365125 NWTEDMEGGISS(ph)PVKK ddPTM_A459_Selumetinib_30min_R2 5 NWTEDMEGGISSPVKK 16 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 NWTEDMEGGIS(0.049)S(0.951)PVKK;NWTEDMEGGIS(0.096)S(0.904)PVKK;NWTEDMEGGIS(0.199)S(0.801)PVKK;NWTEDMEGGIS(0.442)S(0.558)PVKK;NWTEDMEGGIS(0.114)S(0.886)PVKK 180.56 1.8128e-06 244390200.0 443554.0 393524.0 480321.0 462430.0 448635.0 343985.0 403672.0 388424.0 300271.0 422250.0 True False 418903.0443673454 423706.0254209038 449417.66979396273 399446.23626375577 392273.4604522124 391365.8113650702 422443.54786089336 389554.24953294557 360333.59027273214 410058.54536274634 1.0215688688959648 1.0332817843024942 1.0959841585459424 0.9741200147661776 0.956627937372209 0.95441447517905 1.030203010370607 0.9499966625212938 0.8787369373170203 1.0 18.64547037703261 -5.879517251738432 7.151228371008391 0.9625782117096984 1.048204152340381 0.4910994775309635 0.040623548319222366 0.19431734391301383 11.356136148575086 0.011776853969705707 0.017578009317045246 1.3197228865274293e-06 5.879517251738432 0.08562594063068252 NYADHVR ddPTM_A459_Selumetinib_30min_R2 2 NYADHVR 7 0 Q6P587;Q6P587-2;Q6P587-3 Q6P587 FAHD1 Acylpyruvase FAHD1, mitochondrial 0 ; 133.81 0.0043613 2091510.0 12895.7 10883.900000000001 10003.1 12831.599999999999 10651.6 8863.4 13533.5 9957.599999999999 8274.6 8869.7 False True 12179.008619577282 11718.660132745605 9359.511436551795 11083.91394425535 9313.45078148781 10084.252896065705 14162.8345661215 9986.574967430573 9929.751211641313 8613.608714751788 1.413926383574789 1.360482060518498 1.0865958446106987 1.2867909735988914 1.0812484163040124 1.1707349648696337 1.6442393699479325 1.1593950106332813 1.1527980362789734 1.0 13.072402073286124 -5.068339273064755 7.939193495972548 1.2174807176364326 1.401053060735131 0.16568410672368705 0.1672828920192849 0.5208366589972923 55.335560165264624 0.043156879204664475 0.1163969286693656 8.54398991254306e-06 5.068339273064755 0.1835723430986984 NYDPYKPLDIT(ph)PPPDQK ddPTM_A459_Selumetinib_30min_R2 2 NYDPYKPLDITPPPDQK 17 1 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 NYDPY(0.009)KPLDIT(0.991)PPPDQK;NYDPY(0.001)KPLDIT(0.999)PPPDQK 91.276 0.011798 23958000.0 107649.0 90136.0 100119.0 101584.0 84287.0 72976.0 76150.0 85089.0 61070.0 79906.0 True False 101666.2995330905 97049.14136707944 93677.45254132524 87748.08395782566 73698.11352465955 83027.7815898291 79691.12588836232 85336.59490275774 73285.70643836979 77598.9061592789 1.3101511936832082 1.2506508940715886 1.207200683332361 1.1307902172965512 0.9497313450963779 1.0699607210880904 1.026961974499859 1.0997138893632925 0.9444167458745376 1.0 16.2437486957543 -5.791827416673908 1.8231487366446608 1.0230497680886468 1.2785231426038688 0.8285349211294069 0.0493979458484091 0.1352482320594956 0.9173948115787897 0.015100342498496075 0.030074050031515434 1.6150002106963046e-06 5.791827416673908 0.255473374515222 NYGS(ph)PLISGSTPK ddPTM_A459_Selumetinib_30min_R1 3 NYGSPLISGSTPK 13 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NYGS(0.6)PLIS(0.397)GS(0.002)T(0.001)PK;NYGS(0.733)PLIS(0.263)GS(0.004)TPK;NYGS(0.986)PLIS(0.014)GSTPK 157.07 8.599e-05 27888000.0 9301.7 10979.3 12401.1 12853.899999999998 10610.2 9582.4 10476.8 9270.8 5679.18 7869.900000000001 True False 9518.4115120425 9693.838451861902 10717.09873436631 10609.207662586396 9650.509283382951 9486.009756123072 9686.526541079927 9024.908268197556 9637.153669104146 8880.078324317612 1.0718837339505043 1.0916388457200712 1.2068698431429503 1.1947200548370904 1.086759477892842 1.0682349197468395 1.0908154396064167 1.0163095345097728 1.0852554805415764 1.0 13.116356686193129 -6.487967707821873 4.996915192604429 1.057232916235558 1.1427771122722203 0.4488796491861814 0.04634810742239977 0.20664559039292413 13.0029911623594 0.015883643823039504 0.017410651080597934 3.2511147030874945e-07 6.487967707821873 0.0855441960366623 NYGS(ph)PLISGSTPK ddPTM_A459_Selumetinib_30min_R2 3 NYGSPLISGSTPK 13 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NYGS(0.557)PLIS(0.407)GS(0.036)TPK;NYGS(0.887)PLIS(0.112)GS(0.001)TPK;NYGS(0.993)PLIS(0.007)GSTPK 153.79 0.00040206 36219300.0 142322.0 130842.0 138034.0 152192.0 144000.0 109802.0 105298.0 113276.0 98293.0 119770.0 True False 134412.31300010683 140877.16067665993 129153.04272005589 131463.18705415595 125909.43262366654 124926.2288166852 110194.56564402873 113605.61440614858 117954.34653588821 116311.92890016825 1.1556193270208281 1.2112013102076251 1.1104023804033833 1.1302640090079856 1.0825152141680663 1.0740620501953044 0.9474055385893384 0.9767322705451603 1.014120801290551 1.0 16.827639541003514 -6.580089409477386 0.9395963086209286 0.980512941169278 1.1710197602197026 0.8420515436629252 0.031907231963468945 0.20595112440701 0.396132319825145 0.017908202511725542 0.019967654497554284 2.6297265466540973e-07 6.580089409477386 0.19050681905042455 NYGSPLIS(ph)GSTPK ddPTM_A459_Selumetinib_30min_R1 1 NYGSPLISGSTPK 13 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NYGS(0.278)PLIS(0.352)GS(0.352)T(0.017)PK 86.49799999999998 0.039456 0.0 4718.3 4651.3 6849.1 6289.7 4346.8 4688.9 4123.4 3657.9 2249.2 2447.6 True False 4828.227209786391 4106.723633669293 5919.029839413298 5191.321967291608 3953.6327074898713 4641.733923180568 3812.3686182316123 3560.8806094662623 3816.728124931603 2761.7733016429415 1.7482344430348948 1.4869879548861809 2.1431990221254393 1.8797060440128672 1.4315558431743507 1.680707797565884 1.3804060659010955 1.2893457284665408 1.3819845831158855 1.0 11.431379186438264 -7.6360360314990725 0.5626181523685878 1.0504886454861697 1.812033146913314 0.6285425568363503 0.1890150495745878 0.5631010257407618 0.37887633641163015 0.191294679613195 0.1223425222447153 2.3118729763071352e-08 7.6360360314990725 0.7615445014271442 NYGSPLIS(ph)GSTPK ddPTM_A459_Selumetinib_30min_R2 1 NYGSPLISGSTPK 13 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 NYGS(0.038)PLIS(0.957)GS(0.004)T(0.001)PK 101.43 0.010121 20907000.0 51847.0 46945.0 57478.0 57205.0 52960.0 41392.0 46498.0 54543.0 43495.0 56393.0 True False 48965.55129998552 50545.53054803351 53779.92805731463 49413.5803158708 46306.69133159284 47093.37228083484 48660.24913403903 54701.71109992024 52195.21535184042 54764.78756338966 0.8941064775118212 0.9229567537266093 0.9820165557122802 0.902287446265999 0.8455559382567372 0.8599206602659557 0.888531687952141 0.9988482295599812 0.9530798469988587 1.0 15.740960952734836 -7.759127005560768 24.99996465657476 0.9819730396259074 0.8999562986047511 0.5278988250809327 0.03666046853831537 55.699543984781265 602211.7849491728 0.020694993519126313 0.011212852133526801 1.741297571928468e-08 7.759127005560768 -0.0820167410211563 NYGYNPS(ph)PVKPEGLR ddPTM_A459_Selumetinib_30min_R1 2 NYGYNPSPVKPEGLR 15 1 E9PRF4;Q15047-3;Q15047 E9PRF4 SETDB1 Histone-lysine N-methyltransferase SETDB1 1 NYGYNPS(1)PVKPEGLR;NYGYNPS(1)PVKPEGLR 131.37 0.00039389 96942000.0 4737.3 5628.9 5712.9 6422.799999999999 4749.0 4675.6 4400.1 4781.7 2957.7 4231.0 True False 4847.669872818831 4969.865771195383 4937.119558713443 5301.178550888044 4319.453788504046 4628.567709105135 4068.196914459166 4654.873782849402 5019.000878138983 4774.090063430007 1.0154123211776946 1.0410079628084599 1.0341488101643197 1.110406062821392 0.9047700674085479 0.969518305605588 0.8521407975986772 0.975028481030592 1.0512999988385257 1.0 12.221010067847219 -6.266557522034701 24.997891807947557 0.9527480273580914 1.0484344460173578 0.39539563874704997 0.0550788347738867 439.9256944001165 2148670.387181012 0.017297383037342857 0.02023986802719652 5.413055475505003e-07 6.266557522034701 0.09568641865926641 NYGYNPS(ph)PVKPEGLR ddPTM_A459_Selumetinib_30min_R2 4 NYGYNPSPVKPEGLR 15 1 E9PRF4;Q15047-3;Q15047 E9PRF4 SETDB1 Histone-lysine N-methyltransferase SETDB1 1 NYGYNPS(1)PVKPEGLR;NYGYNPS(1)PVKPEGLR;NYGYNPS(0.999)PVKPEGLR;NYGYNPS(1)PVKPEGLR 75.143 0.021578 162465000.0 201250.0 196957.0 204167.0 214034.0 188781.0 145801.0 178374.0 155627.0 119630.0 178352.0 True False 190065.33066758097 212062.96858342856 191031.11750022232 184882.19997075584 165064.64305644706 165883.7643002997 186668.74444137557 156079.8488045632 143559.3427414799 173202.51434585307 1.0973589580117526 1.2243642615948314 1.1029350135112292 1.0674336955731523 0.9530152820232379 0.9577445508040421 1.0777484677193137 0.9011407795899596 0.8288525330228099 1.0 17.402100347965444 -5.976932880637143 1.5836198556217171 0.9510107122047778 1.161445379015085 0.6171325068439447 0.06767709034442611 0.2629053673821718 1.3344173281212477 0.023901815331962818 0.04180530180650021 1.054549862416816e-06 5.976932880637143 0.2104346668103071 NYILDQTNVYGS(ph)AQR ddPTM_A459_Selumetinib_30min_R1 4 NYILDQTNVYGSAQR 15 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-3;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 NYILDQTNVYGS(1)AQR;NYILDQTNVYGS(1)AQR;NYILDQTNVYGS(1)AQR;NYILDQTNVYGS(1)AQR 249.36 5.5707e-28 55811000.0 8560.4 10313.4 9223.300000000001 10937.800000000001 8989.6 8397.0 9074.699999999999 8720.3 5115.759999999999 7437.5 True False 8759.840664361196 9105.90233343042 7970.826519960389 9027.718557934752 8176.492267242783 8312.533803865988 8390.188072917119 8489.009316473564 8681.071079672813 8392.175572384935 1.0438104623533009 1.0850466908001848 0.9497926313873812 1.0757304205647362 0.9742994765443334 0.9905099973383524 0.9997631723203747 1.0115385746226842 1.0344243879070536 1.0 13.034829145460899 -5.2372866290729085 24.999737254218513 1.0057149096382663 1.0644285817061605 0.34213345945854357 0.033202471188607585 849.6193835600973 879410.8704792024 0.007954962428995068 0.021030701549087556 5.7904640670575644e-06 5.2372866290729085 0.05871367206789424 NYILDQTNVYGS(ph)AQR ddPTM_A459_Selumetinib_30min_R2 4 NYILDQTNVYGSAQR 15 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-3;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 NYILDQTNVYGS(1)AQR;NYILDQTNVYGS(1)AQR;NYILDQTNVYGS(1)AQR;NYILDQTNVYGS(1)AQR 206.81 1.9662e-06 40203700.0 156749.0 129249.0 144033.0 163163.0 172196.0 123199.0 120720.0 122717.0 114826.0 148360.0 True False 148037.51809596372 139161.98269896233 134766.07359127302 140939.91792812583 150563.19902822835 140168.54396082746 126333.71920214196 123074.08615310694 137794.40850650484 144076.46131442708 1.027492740628132 0.9658897881678286 0.9353788423298693 0.9782300081658989 1.0450228833677755 0.9728760873362157 0.8768519024522401 0.8542275749299162 0.9563977852411816 1.0 17.136475126959503 -7.131013074865137 6.013201801783728 0.9101687021556745 0.9874235815296294 0.3052344179433515 0.047607594882486094 0.26230834088765015 11.720227813440964 0.018505990895884384 0.014302199709680618 7.39583008844726e-08 7.131013074865137 0.07725487937395492 NYPS(ph)QEELIK ddPTM_A459_Selumetinib_30min_R1 2 NYPSQEELIK 10 0 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;K7EPC7 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NYPS(1)QEELIK;NYPS(1)QEELIK 169.09 0.00024582 40804000.0 8163.6 10084.6 9629.3 10129.5 9380.099999999999 9512.4 9307.5 9049.0 4789.5 7169.1 True False 8353.795996399593 8903.890343796653 8321.693949958746 8360.572979264569 8531.671611191165 9416.713892568156 8605.427781488755 8808.991124705488 8127.4316887604045 8089.323817947545 1.0326939784343 1.1006964913484925 1.0287255322250357 1.0335317472042858 1.0546829133310496 1.1640915983206865 1.0638006309496655 1.0889650758152662 1.0047108845770658 1.0 12.981803398285887 -8.272692966223746 22.652109884252567 1.0023553574537367 1.0715697595673082 0.3357936283419838 0.038550902440704984 277.40940689894177 558370.3919526029 0.03684198203101433 0.009951161352794878 5.3371208131743846e-09 8.272692966223746 0.06921440211357144 NYPS(ph)QEELIK ddPTM_A459_Selumetinib_30min_R2 2 NYPSQEELIK 10 0 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;K7EPC7 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 NYPS(1)QEELIK;NYPS(1)QEELIK 149.57 0.00074328 33656000.0 178053.0 194320.0 203221.0 186053.0 193506.0 147109.0 151328.0 177739.0 108606.0 170596.0 True False 168157.52706263275 209223.71916271927 190145.98211029524 160712.26044067324 169196.0463144112 167371.92942745768 158365.0518507433 178256.19106372478 130330.234705184 165670.45021836116 1.0150121934297487 1.2628909916460838 1.1477362550755081 0.9700719725747543 1.0212807781436166 1.0102702636882672 0.9559040350407148 1.0759685316770435 0.7866836513898697 1.0 17.337956773887136 -5.7577281262214495 22.062694100396097 0.9801650084946456 1.153981193165188 0.41695035291936444 0.0902811179028194 19.277165880368763 114587.5310090176 0.023452003190770013 0.038563788889015876 1.7469154015858523e-06 5.7577281262214495 0.17381618467054238 NYQQNYQNS(ph)ES(ph)GEKNEGSESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R2 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 2 NY(0.005)QQNY(0.1)QNS(0.738)ES(0.738)GEKNEGS(0.271)ES(0.147)APEGQAQQR 73.839 0.00017350000000000002 9773600.0 71852.0 64500.0 61632.0 65710.0 58773.0 53230.0 58298.0 59825.0 41403.0 64294.0 True False 67858.75348634562 69446.94259981175 57666.66421984782 56760.18464392737 51389.41030271351 60561.94932617028 61008.97251529548 59999.080845438075 49684.75689647658 62437.66516412634 1.0868240077198463 1.1122604027114167 0.923587774595074 0.9090696215933941 0.823051441267528 0.9699585845654948 0.9771180961832039 0.9609436978099982 0.7957497572318422 1.0 15.930128968769234 -5.265078294015078 23.5263021013542 0.9185206432347226 1.0995422291186387 0.5686254185361366 0.06256491607236239 88.48551642055196 572087.343027935 0.01635944410444264 0.036402850851343455 5.431524038932361e-06 5.265078294015078 0.18102158588391615 NYQQNYQNS(ph)ESGEK ddPTM_A459_Selumetinib_30min_R1 4 NYQQNYQNSESGEK 14 0 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNYQNS(0.935)ES(0.065)GEK;NYQQNYQNS(0.999)ES(0.001)GEK;NYQQNYQNS(0.674)ES(0.326)GEK;NYQQNYQNS(0.982)ES(0.018)GEK 275.76 3.5166e-45 66178000.0 16175.4 16883.7 9967.300000000001 8949.4 9726.2 10998.3 12945.800000000001 12844.6 7539.700000000001 13534.400000000001 True False 16552.25534815057 14906.948554980821 8613.795406459853 7386.5552910440165 8846.466927300076 10887.667087657408 11969.287883276631 12503.919482859106 12794.320222099763 15271.672076220064 1.083853507693145 0.9761176432142513 0.5640374782452687 0.48367691855732176 0.5792729756864771 0.7129322207363848 0.7837575233110416 0.8187655824753662 0.8377812303881346 1.0 13.89857040920263 -8.445477230945777 1.0669697698545315 0.9929104125060759 0.7240918147559192 0.16882672888535022 0.1737283442069215 1.007915656340812 2.509755380966054 0.18615647355565015 0.061091555321577 3.5852774456342477e-09 8.445477230945777 -0.2688185977501567 NYQQNYQNS(ph)ESGEK ddPTM_A459_Selumetinib_30min_R2 4 NYQQNYQNSESGEK 14 0 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNYQNS(1)ESGEK;NYQQNYQNS(0.774)ES(0.226)GEK;NYQQNYQNS(0.998)ES(0.002)GEK;NYQQNYQNS(0.927)ES(0.073)GEK 264.85 2.3247999999999998e-36 127545000.0 414459.0 301148.0 346924.0 386479.0 363984.0 347332.0 509191.0 449650.0 359420.0 324631.0 True False 391425.0279908321 324245.08325655956 324603.28754229064 333839.89348653855 318257.075861754 395173.830234029 532869.3904428254 450958.4070564355 431314.04303387663 315258.0595373668 1.2416019706688495 1.0285068801488564 1.0296431057738469 1.05894166187675 1.0095128934333613 1.2534931884499212 1.6902641322629395 1.4304421200784065 1.3681301079719232 1.0 18.266173727800656 -6.981960812168642 6.043143278208256 1.4172562505118294 1.0720399456206056 0.3994678744615835 0.16973041823719512 0.1376680999105166 17.90204367537587 0.059096448094884284 0.050604219074325 1.0424114853950373e-07 6.981960812168642 -0.3452163048912238 NYQQNYQNS(ph)ESGEKNEGSESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R1 4 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNY(0.007)QNS(0.795)ES(0.197)GEKNEGS(0.001)ES(0.001)APEGQAQQR;NYQQNY(0.008)QNS(0.819)ES(0.173)GEKNEGSESAPEGQAQQR;NYQQNY(0.021)QNS(0.476)ES(0.476)GEKNEGS(0.02)ES(0.007)APEGQAQQR;NYQQNY(0.016)QNS(0.48)ES(0.48)GEKNEGS(0.019)ES(0.004)APEGQAQQR 119.18 7.7163e-14 466617400.0 2948.15 3057.59 3803.5899999999997 3407.2 2460.6980000000003 3001.278 2647.3199999999997 2805.71 1549.09 2349.52 True False 3016.8361588987045 2699.6059413649737 3287.083369624336 2812.1964810652294 2238.1283003715175 2971.0878682623916 2447.630521030439 2731.293456569504 2628.692588942867 2651.10377826284 1.137954758178314 1.0182950827877115 1.239892378629639 1.0607643895811376 0.8442250804071018 1.1206984398812272 0.9232496068615885 1.0302476572075987 0.9915464684922074 1.0 11.372377430708333 -6.002289915302711 24.99954556521871 0.9867766756997548 1.1256148875460894 0.38765476205339144 0.08313132745734353 94.0313655875168 1026591.8713932756 0.022233673280765278 0.03237963586533127 9.947411515738285e-07 6.002289915302711 0.1388382118463346 NYQQNYQNS(ph)ESGEKNEGSESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R2 6 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNY(0.002)QNS(0.964)ES(0.033)GEKNEGSESAPEGQAQQR;NYQQNY(0.03)QNS(0.827)ES(0.142)GEKNEGSESAPEGQAQQR;NYQQNY(0.044)QNS(0.59)ES(0.359)GEKNEGS(0.005)ES(0.001)APEGQAQQR;NYQQNY(0.002)QNS(0.843)ES(0.155)GEKNEGSESAPEGQAQQR;NYQQNY(0.046)QNS(0.784)ES(0.17)GEKNEGSESAPEGQAQQR;NYQQNY(0.115)QNS(0.497)ES(0.386)GEKNEGS(0.001)ESAPEGQAQQR 125.91 6.8334e-14 935358000.0 205293.0 203206.2 195148.0 216374.0 210532.0 158018.3 172828.0 178670.0 128199.8 175597.3 True False 193883.63691299246 218791.46212908323 182592.3901410768 186903.48793403094 184083.08798003962 179783.88647769252 180864.84445218512 179189.90011958944 153843.34220169825 170527.34969242272 1.13696505142839 1.283028572975031 1.0707513514425433 1.0960323271964618 1.0794930450280682 1.0542818310491875 1.0606207437012771 1.050798598833508 0.9021622776591723 1.0 17.37964361604005 -5.698287086253991 0.36856169536438244 0.9731591179096769 1.2839008021064566 0.6008165466015911 0.058006379620848425 2.161737715589064 0.3840487341182603 0.0567827446794968 0.2815649751522011 2.003147427971316e-06 5.698287086253991 0.3107416841967797 NYQQNYQNSES(ph)GEKNEGSESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNY(0.008)QNS(0.209)ES(0.543)GEKNEGS(0.209)ES(0.032)APEGQAQQR 66.556 0.00031704 293100000.0 448.39 423.05 400.19 630.92 416.9 332.2 392.42 584.77 230.18 372.69 True False 458.8366145849399 373.5191093293908 345.84639608631903 520.7416658351946 379.1914686096733 328.85836961346666 362.8194434608454 569.2599999993404 390.5986483179599 420.52839180801925 1.0910954492566325 0.8882137724957956 0.8224091472145019 1.2383032298873293 0.9017024200895877 0.7820122874452624 0.8627703872762073 1.3536779230336022 0.9288282454333714 1.0 8.716059396528335 NYQQNYQNSES(ph)GEKNEGSESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R2 2 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNY(0.001)QNS(0.047)ES(0.474)GEKNEGS(0.351)ES(0.128)APEGQAQQR;NYQQNY(0.006)QNS(0.223)ES(0.67)GEKNEGS(0.075)ES(0.025)APEGQAQQR 108.49 6.3931e-11 24401700.0 45170.2 44918.9 46593.0 47424.0 40671.3 39843.1 40803.3 38355.2 29766.4 44139.0 True False 42659.82111463741 48364.03519297186 43595.25710662269 40964.769389036905 35561.80768796477 45331.12536534914 42700.734300205084 38466.80728195482 35720.51174270656 42864.59238310529 0.9952228341135796 1.1282980311748894 1.0170458805950382 0.9556785008687686 0.8296313043205596 1.0575424340956991 0.99617730920113 0.8974028479766012 0.8333337553627477 1.0 15.387498803838433 -5.668346461645785 3.3871037323589945 0.9364495223202097 1.0635255120174312 0.3189371496013311 0.074275029799269 0.2762562105130877 6.207841632682958 0.02148139277524179 0.03943117355273406 2.146117709707106e-06 5.668346461645785 0.12707598969722145 NYQQNYQNSESGEKNEGS(ph)ESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNY(0.007)QNS(0.008)ES(0.033)GEKNEGS(0.777)ES(0.176)APEGQAQQR 79.558 1.9022e-05 15798000.0 74.196 269.24 390.89 322.74 230.82 139.72 137.54 192.79 130.09 141.16 True False 75.92462243971586 237.71725563371987 337.80928500507576 266.37951758012207 209.9423717545808 138.31454365560975 127.16524706591075 187.6765829298233 220.75322860232623 159.2792610148381 0.47667613445697044 1.4924557919161532 2.1208617044852196 1.6724055340469386 1.318077258878185 0.8683776078213011 0.7983791879475401 1.1782863740957445 1.385950858861414 1.0 7.315414622495869 -6.558293383724953 5.950709438296018 1.0442686334077 1.49389442811181 0.16854352916282167 0.41088023207767954 0.31459984381153183 30.642243128271566 0.14454314161545498 0.1463974715517721 2.765073094121216e-07 6.558293383724953 0.44962579470411 NYQQNYQNSESGEKNEGS(ph)ESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R2 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NY(0.001)QQNY(0.041)QNS(0.047)ES(0.037)GEKNEGS(0.437)ES(0.437)APEGQAQQR 42.353 0.037529 134320000.0 9398.8 13026.0 10099.0 8422.8 13256.0 11032.0 16092.0 10545.0 3207.8 15759.0 True False 8876.452322377456 14025.052314808498 9449.241334959821 7275.600109859565 11590.662769856403 12551.55786147493 16840.309885693074 10575.684204181276 3849.449633420707 15303.996723200717 0.5800087704488878 0.9164306924835294 0.6174361838848841 0.47540523181306116 0.7573618172751609 0.8201490165276163 1.100386401688346 0.6910406735874843 0.2515323090461054 1.0 13.901620849445003 -6.492726542434407 24.468881719693044 0.7754591226785352 0.6584047803699853 0.06142100922771554 0.23398928945595684 1929.2631593335343 1565621.5301149855 0.0758067512730974 0.0858255105620681 3.215684687125928e-07 6.492726542434407 -0.11705434230854994 NYQQNYQNSESGEKNEGSES(ph)APEGQAQQR ddPTM_A459_Selumetinib_30min_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NYQQNY(0.025)QNS(0.068)ES(0.22)GEKNEGS(0.297)ES(0.39)APEGQAQQR 53.957 0.004463399999999999 275210000.0 325.76 365.48 132.26 378.07 227.73 300.48 274.55 0.0 111.76 70.94800000000002 True False 333.3495741813821 322.68943169295744 114.29981845217662 312.04717175285595 207.1318617089971 297.45744401401134 253.84047245852685 0.0 189.64855737255726 80.05486689204258 4.164013846040344 4.030853391188795 1.4277685153897617 3.8979163149901295 2.5873737569050395 3.7156697095648843 3.170831235043356 0.0 2.368982233501262 1.0 6.3229172081545375 -7.719733472817667 13.790024936235353 1.1386736903231391 3.255839212652324 0.5306790057855214 0.9313699084758523 1.193419433084256 393.9328295984437 0.42426721506787185 0.24467767753324696 1.90663046099611e-08 7.719733472817667 2.117165522329185 NYQQNYQNSESGEKNEGSES(ph)APEGQAQQR ddPTM_A459_Selumetinib_30min_R2 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 NY(0.001)QQNY(0.016)QNS(0.044)ES(0.124)GEKNEGS(0.368)ES(0.448)APEGQAQQR 44.164 0.028914 12430000.0 4993.2 5913.1 6733.5 7049.4 6109.3 5767.1 4211.5 5119.5 5383.1 6023.9 True False 4715.6979333633135 6366.615756386778 6300.273940880473 6089.259559106709 5341.795116165038 6561.465676478613 4407.343094928932 5134.396897421153 6459.870416381012 5849.974355028164 0.8061057446021249 1.0883151566150973 1.0769746256178487 1.0409036330001815 0.9131313732296389 1.121622981276646 0.7533952847401352 0.8776785308482663 1.1042561940170952 1.0 12.514214584921413 -7.232274154408696 24.996896321905545 0.92363890191127 1.011840220570264 0.080349777485899 0.12025259020131748 1636.7964962250217 1402865.649266598 0.04544987983290611 0.03519949970423285 5.8576827343866124e-08 7.232274154408696 0.08820131865899394 NYQQNYQNSESGEKNEGSESAPEGQAQQR ddPTM_A459_Selumetinib_30min_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 118.04 4.0168e-13 6285900.0 214.04 258.89 57.142 253.71 128.24 280.49 227.7 171.31 59.557 0.0 False True 219.02671555066016 228.57903844530426 49.382430258538314 209.40431122653777 116.64071464261094 277.6685252645433 210.52440567767826 166.76630230669656 101.0638791288242 0.0 0.0 NYQVT(ph)NSMFGASRK ddPTM_A459_Selumetinib_30min_R1 1 NYQVTNSMFGASRK 14 1 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8W145;F8VVD4;F8VRS8 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 NYQVT(0.406)NS(0.188)MFGAS(0.406)RK 104.22 0.0067697 0.0 772.41 887.66 985.11 1180.6 785.41 777.49 824.68 635.54 508.21 562.14 True False 790.4056501517728 783.7323545380619 851.3374728218945 974.4303726067177 714.3698041753983 769.6691565044378 762.4737236463228 618.6834146751379 862.3952518101939 634.2961447072903 1.2461145424689954 1.2355937539234647 1.342176647179154 1.53623883849458 1.1262401799794317 1.213422409905421 1.2020784455472022 0.9753857403006017 1.359609795844124 1.0 9.30901276317903 -6.3435816578198265 24.999999214494796 1.1510543813007081 1.3327375893898108 0.3558189558593732 0.12756326177061192 112.68494039026639 34294.247051407234 0.039050925755180335 0.04427959296207169 4.533340520476791e-07 6.3435816578198265 0.18168320808910265 NYS(ph)SPPPCHLSR ddPTM_A459_Selumetinib_30min_R1 1 NYSSPPPCHLSR 12 0 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 NYS(0.87)S(0.127)PPPCHLS(0.003)R 120.53 0.0040101 9850200.0 2935.4 4015.1 3204.0 3359.4 5628.7 3087.6 5344.7 3038.1 937.41 1981.7 True False 3003.7891087058847 3545.01022543065 2768.9143983122185 2772.7438537481007 5119.585078827701 3056.541547316494 4941.544975957344 2957.5197188603997 1590.7163042824698 2236.070498392637 1.3433338129835841 1.585374981682788 1.2382947676750835 1.240007350278644 2.2895454693883006 1.3669253941294066 2.2099236046043687 1.3226415361172041 0.7113891558544019 1.0 11.126749958566858 -8.006369446008037 24.82010600026073 0.9094679791192647 1.6097474754917347 0.4120154726520828 0.35706941356738564 249.79585440409642 973384.9222982539 0.20608864480523698 0.09340654636925808 9.854408333028703e-09 8.006369446008037 0.70027949637247 NYS(ph)VGSR ddPTM_A459_Selumetinib_30min_R2 1 NYSVGSR 7 0 O60825 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 NYS(1)VGSR 84.81700000000002 0.037033 3318900.0 21384.0 18028.0 19968.0 22232.0 19586.0 25144.0 24423.0 23356.0 17108.0 20880.0 True False 20195.562886934447 19410.6896308435 18683.280619514575 19203.963247660868 17125.43157893841 28607.357765493623 25558.717893256384 23423.96209320605 20530.078037459152 20277.140147244812 0.9959768853143006 0.9572695897888222 0.9213962365424196 0.9470745434617038 0.8445683885686095 1.4108181704992897 1.2604695587079233 1.1551906197378043 1.012474041624095 1.0 14.30756657102638 -6.739817871546586 24.999966111202028 1.1832824431194873 0.9346998301742363 0.5042513602554569 0.11576085020741005 196.24724453775127 226911.289666795 0.039093205218399964 0.03905995338822076 1.820464139792728e-07 6.739817871546586 -0.24858261294525097 NYSEVIEVDES(ph)DVEEDIFPTTSK ddPTM_A459_Selumetinib_30min_R1 1 NYSEVIEVDESDVEEDIFPTTSK 23 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 NYSEVIEVDES(1)DVEEDIFPTTSK 105.53 1.4091e-05 9265300.0 3752.6 4554.7 5068.0 5177.1 4449.4 4299.5 4954.9 4338.0 2802.1 3890.7 True False 3840.028278711489 4021.433606577417 4379.79343653131 4273.016671202983 4046.952555605374 4256.250933633657 4581.147903787126 4222.942148190119 4754.959042713341 4390.109243627304 0.8746999369743899 0.9160213068535692 0.9976502163104556 0.9733280959706657 0.9218341346470917 0.9695091163874895 1.0435156962066796 0.9619218825408855 1.0831072255469847 1.0 12.100041124941722 -1.5919849967775637 0.28048576231466626 1.0223610738189364 1.2923942338651316e-14 0.5209143400664984 0.04040799157831716 42.93494008042835 0.6274103779569874 0.04553728915497546 21.37121714828408 0.025586742778427953 1.5919849967775637 -1.0223610738189235 NYSS(ph)PPPCHLSR ddPTM_A459_Selumetinib_30min_R2 1 NYSSPPPCHLSR 12 0 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 NY(0.001)S(0.388)S(0.611)PPPCHLSR 102.15 0.0078541 12737000.0 6432.9 7961.0 15730.0 14120.0 16582.0 8343.1 8666.0 10251.0 10470.0 12475.0 True False 6075.385170939044 8571.58310135041 14717.948925529054 12196.831641641384 14498.820915039136 9492.286293878851 9068.986171353234 10280.8287128556 12564.292556242535 12114.814336057429 0.5014839685043146 0.7075290519177609 1.2148720167938434 1.0067700010341756 1.196784408976551 0.7835271784254155 0.7485864760107078 0.8486162831448997 1.0371015359969091 1.0 13.564484674681118 -5.028894942488655 5.878809881675327 0.9681987355054004 0.5446261508360307 0.5257487036811512 0.14805520184920493 0.13043844753683886 14.890463456322202 0.04108243338443864 0.12576372331317978 9.356319797613509e-06 5.028894942488655 -0.42357258466936965 NYTEDIFPVT(ph)PPELEETIRDEK ddPTM_A459_Selumetinib_30min_R1 2 NYTEDIFPVTPPELEETIRDEK 22 1 Q5T3J3;Q5T3J3-2 Q5T3J3 LRIF1 Ligand-dependent nuclear receptor-interacting factor 1 1 NYTEDIFPVT(1)PPELEETIRDEK;NYTEDIFPVT(1)PPELEETIRDEK 124.51 4.4515e-05 3386300.0 2074.39 2540.0 2756.0 3071.6 2133.17 2365.97 2323.92 2220.4 1224.6399999999999 1473.97 True False 2122.7192509397028 2242.615619186037 2381.750337624367 2535.2027210730107 1940.2251501417516 2342.1704899288793 2148.6248434012737 2161.5077791243293 2078.1246358332905 1663.168407183628 1.2763104696861503 1.3483996025295069 1.4320560247158431 1.5243211151215084 1.1665836975747303 1.4082581654464315 1.2918865185995847 1.2996325385861422 1.249497421221667 1.0 10.699718543430121 -9.234918299967783 0.47280147144192125 0.969700581427443 1.37320351279118 0.5829390372012985 0.08967074016701951 1.9908804710590275 0.6978855375396997 0.2110932204315814 0.050367689315987695 5.822127340719759e-10 9.234918299967783 0.40350293136373694 NYTNS(ph)PEESSK ddPTM_A459_Selumetinib_30min_R1 2 NYTNSPEESSK 11 0 J3QQU0;A0A3B3ITH3;Q9P2X3-2;Q9P2X3 J3QQU0 IMPACT Protein IMPACT 1 NYT(0.004)NS(0.49)PEES(0.465)S(0.041)K;NYT(0.003)NS(0.476)PEES(0.476)S(0.045)K 201.3 1.8773e-05 15990000.0 5949.299999999999 7122.200000000001 7298.0 8554.3 5679.5 6176.0 6702.9 5812.8 3809.8 5095.5 True False 6087.9071146773595 6288.32951297905 6306.971685044499 7060.452089098462 5165.790227797168 6113.875047359331 6197.294856464252 5658.625661364575 6464.952343217329 5749.5570593731 1.0588480211275877 1.0937067756772023 1.0969491423278748 1.227999307805512 0.898467512271357 1.0633645312541613 1.0778734418090932 0.9841846255164498 1.1244261560423983 1.0 12.489235101091225 -6.254185065882388 24.998986555370852 1.0285185696092443 1.1159403927593847 0.302765297009305 0.07015144203932136 795.1531315510836 2740161.2696767338 0.02054714775210665 0.02599753882005603 5.569483659826328e-07 6.254185065882388 0.08742182315014047 NYTNS(ph)PEESSK ddPTM_A459_Selumetinib_30min_R2 2 NYTNSPEESSK 11 0 J3QQU0;A0A3B3ITH3;Q9P2X3-2;Q9P2X3 J3QQU0 IMPACT Protein IMPACT 1 NYT(0.035)NS(0.963)PEES(0.002)SK;NYT(0.039)NS(0.942)PEES(0.015)S(0.004)K 153.7 0.00055596 9870800.0 64105.0 60808.0 63835.0 67984.0 62001.0 52410.0 58466.0 64499.0 45302.0 68166.0 True False 60542.300732647425 65471.77807146282 59727.925598292866 58724.4619210586 54211.88008402734 59629.00176938911 61184.784848181196 64686.68141161573 54363.665843638904 66197.87046346224 0.9145656847989333 0.9890314841411675 0.9022635498714351 0.8871050006581621 0.8189369190350233 0.9007691841431847 0.9242711951278251 0.9771716364700794 0.8212298290417787 1.0 16.014497186895866 -10.101870117800761 13.581587569291028 1.00000287571156 0.906046541744402 0.23091309566094542 0.05247180022989844 0.0 0.0 0.0523406796221528 0.012694479446985289 7.909151275206552e-11 10.101870117800761 -0.09395633396715797 PAAAAAAGSAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 PAAAAAAGSASPR 13 0 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 PAAAAAAGS(0.012)AS(0.988)PR 91.202 0.024062 0.0 5926.5 4185.4 6064.4 5877.4 5893.1 5296.8 4689.4 5380.1 5111.5 5862.3 True False 5597.128855659228 4506.406721817864 5674.223106419479 5076.887980919481 5152.75609301756 6026.386120436947 4907.466391869818 5395.755200276497 6133.94282724295 5693.040166915384 0.983152883442921 0.7915641888505304 0.9966947254991703 0.8917709750975202 0.9050974421298413 1.0585532411063554 0.8620115523493298 0.947780982054802 1.077445907178002 1.0 12.474983563278412 -7.575417031096401 0.5351536929262288 1.021404549483513 0.9062669562432641 0.17612698314905795 0.07704099933103538 1.511138186117836 0.9364828273970038 0.07382356605977967 0.05135493818432728 2.6581713259691322e-08 7.575417031096401 -0.11513759324024875 PAAMIS(ph)QPPTPPTGQPVR ddPTM_A459_Selumetinib_30min_R2 1 PAAMISQPPTPPTGQPVR 18 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 PAAMIS(0.739)QPPT(0.219)PPT(0.041)GQPVR 106.35 0.0016667 7120500.0 14916.0 10444.0 13617.0 15232.0 13832.0 13653.0 19212.0 19057.0 16465.0 15495.0 True False 14087.028433478956 11245.021217247046 12740.897045068607 13157.375323334383 12094.300500351066 15533.576820405826 20105.39606785578 19112.452714943825 19758.46007053804 15047.619089155092 0.9361632793876049 0.7472957117416269 0.8467051810376465 0.8743825348966323 0.8037351576149013 1.032294659266127 1.3361180894289024 1.2701313478036058 1.3130622162530734 1.0 13.87724761404271 -7.007045621810392 3.5027443376078624 1.2503164669426792 0.8398808081189094 0.7744965485041089 0.09826229423491337 0.09874581146017339 2.5773798002730914 0.03626998296282139 0.02947060299380907 9.839077426927205e-08 7.007045621810392 -0.41043565882376976 PAAMISQPPT(ph)PPTGQPVR ddPTM_A459_Selumetinib_30min_R2 1 PAAMISQPPTPPTGQPVR 18 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 PAAMISQPPT(0.5)PPT(0.5)GQPVR 148.33 0.00021425 0.0 13581.0 10382.0 12677.0 15136.0 13863.0 11837.0 16643.0 16208.0 15964.0 12593.0 True False 12826.222389050545 11178.266016608466 11861.375621673986 13074.45068894362 12121.406003207554 13467.439304412499 17416.932477478855 16255.162596621147 19157.246071428443 12229.407369456607 1.04880163049311 0.9140480547345733 0.9699060030740497 1.0690992861679904 0.991168716276572 1.1012340089388077 1.424184504719197 1.3291864524211543 1.56649014074667 1.0 13.57806687287822 -7.10437664119588 3.683641156390034 1.3565762064381797 0.998628116366967 0.5550983984355609 0.1391174662212463 0.1636199110963578 4.033219795950981 0.0525176961840787 0.040334175104843877 7.86363521381681e-08 7.10437664119588 -0.35794809007121264 PAAMISQPPT(ph)PPTGQPVREDAK ddPTM_A459_Selumetinib_30min_R2 1 PAAMISQPPTPPTGQPVREDAK 22 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 PAAMIS(0.031)QPPT(0.933)PPT(0.036)GQPVREDAK 104.23 0.00010107 7031800.0 27048.0 25536.0 27570.0 25802.0 20484.0 23672.0 24069.0 20491.0 19695.0 27552.0 True False 25544.780441722916 27494.529088818486 25796.176215946347 22287.72308906736 17910.61679071654 26932.603126979193 25188.25619181869 20550.625417532345 23634.55032427859 26756.502171306944 0.9547129994112814 1.0275830866376467 0.9641086884521689 0.8329834350682879 0.6693930572854726 1.006581613491359 0.9413882289453364 0.7680609851750488 0.8833198813865788 1.0 14.707601906965976 -5.655912703049247 5.214638797287364 0.8624051900733555 0.9916746710130051 0.20846578242398484 0.09809879724986803 0.3003247522751135 12.608384071731997 0.027439500895167196 0.04825658819604175 2.2084486056955965e-06 5.655912703049247 0.12926948093964963 PAAMISQPPTPPT(ph)GQPVREDAK ddPTM_A459_Selumetinib_30min_R2 1 PAAMISQPPTPPTGQPVREDAK 22 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 PAAMIS(0.02)QPPT(0.394)PPT(0.586)GQPVREDAK 70.986 0.0052295 5238700.0 41419.0 34629.0 32669.0 34543.0 29305.0 24639.0 27552.0 29734.0 24573.0 31876.0 True False 39117.097793393994 37284.932950215225 30567.112107317782 29838.183810001305 25623.443909976 28032.798599427195 28833.222593252263 29820.521017271327 29488.286626986403 30955.657056205742 1.2636494105865574 1.2044626571006878 0.9874483378536438 0.9639008390558321 0.8277467302164473 0.9055791821355446 0.9314362974399217 0.9633302553755081 0.9525976648935264 1.0 14.917915461401007 -5.260183636155283 2.14348035804109 0.9273765326952982 1.2695671561879862 0.882215918207998 0.04336462958866929 0.10956542028179708 0.9231302571233462 0.012745268668217489 0.047948790949850884 5.4930855628281355e-06 5.260183636155283 0.34219062349268803 PAANRAS(ph)GEWDSGTENR ddPTM_A459_Selumetinib_30min_R1 1 PAANRASGEWDSGTENR 17 1 A0A0U1RQE4;Q5HYK7-2;Q5HYK7;Q5HYK7-3;A0A0U1RQN2;A0A494C1M0 A0A0U1RQE4;A0A494C1M0 SH3D19 SH3 domain-containing protein 19 1 PAANRAS(1)GEWDSGTENR 124.04 0.004817 0.0 3523.5 2485.0 2307.1 1885.4 2447.8 1754.3 2586.6 3079.9 1538.4 2567.9 True False 3605.5906944624885 2194.055044754842 1993.8084919931696 1556.1502833412724 2226.3969221941916 1736.653334776956 2391.490679516393 2998.2110470748617 2610.5524397095733 2897.5149784641717 1.2443734445761632 0.7572195695491456 0.6881098136893802 0.5370637580503933 0.7683815057875192 0.5993595711099549 0.8253592120459039 1.0347525618880713 0.9009625348315876 1.0 11.500600403805871 -7.592400959911512 5.35369444778548 0.9727541333764484 0.7484894081273683 0.21294730941741236 0.18083934758145842 0.31366199936947026 16.69255822395358 0.08968922847207454 0.0509041501894145 2.5562247771390738e-08 7.592400959911512 -0.22426472524908014 PAANRAS(ph)GEWDSGTENR ddPTM_A459_Selumetinib_30min_R2 1 PAANRASGEWDSGTENR 17 1 A0A0U1RQE4;Q5HYK7-2;Q5HYK7;Q5HYK7-3;A0A0U1RQN2;A0A494C1M0 A0A0U1RQE4;A0A494C1M0 SH3D19 SH3 domain-containing protein 19 1 PAANRAS(0.987)GEWDS(0.01)GT(0.003)ENR 89.50200000000002 0.045077 2903500.0 10421.0 8958.0 9149.5 9703.6 9196.7 9492.2 9646.1 8338.6 8583.7 12495.0 True False 9841.842538568264 9645.049795490137 8560.83113122238 8381.952940356327 8041.32832645884 10799.66438838763 10094.662763384531 8362.863945470463 10300.679848616917 12134.236884091186 0.8110804686425392 0.7948624942484398 0.7055104670361442 0.6907688567828801 0.6626974900252336 0.8900159516868117 0.831915748786751 0.6891957051238013 0.8488939145503095 1.0 13.566795760543199 -6.765381710998145 24.999997382228454 0.8313234582890541 0.7325500649953327 0.3227863927894383 0.0835535976498489 153.28189708096318 972017.8298971552 0.02960857316123627 0.02707736098027027 1.7163991429402586e-07 6.765381710998145 -0.09877339329372137 PAAPPRPLDRES(ph)PGVENK ddPTM_A459_Selumetinib_30min_R2 1 PAAPPRPLDRESPGVENK 18 2 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 PAAPPRPLDRES(1)PGVENK 70.986 0.025564 5953200.0 18992.0 17567.0 19608.0 20366.0 16879.0 13501.0 18076.0 18400.0 10625.0 20320.0 True False 17936.500670999754 18914.332413192136 18346.442627576198 17592.1156666904 14758.50911982546 15360.640200124444 18916.569816914496 18453.54095371602 12750.296887304394 19733.30880229956 0.9089454206944544 0.9584977665270211 0.929719532156627 0.8914934562135041 0.7478983513451947 0.7784117886167391 0.9586111486133593 0.9351468189443015 0.646130713051963 1.0 14.268345261228662 -6.008369487331878 11.986450081827334 0.8413701001047965 0.9309661375731285 0.13612105003080366 0.09988323914605224 0.9572380436155487 1361.6417023099782 0.02875233720875479 0.0399586136625205 9.809130506135702e-07 6.008369487331878 0.089596037468332 PAAS(ph)PAVGEK ddPTM_A459_Selumetinib_30min_R1 1 PAASPAVGEK 10 0 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 PAAS(1)PAVGEK 119.03 0.0055279 13366000.0 7087.7 8967.7 5761.9 6586.9 5192.4 6133.3 7025.1 6812.8 3206.1 7491.9 True False 7252.829619736566 7917.7575150293715 4979.465627851177 5436.621566426553 4722.748336792678 6071.604570590838 6495.191051059545 6632.102412906789 5440.517535720792 8453.558342285816 0.8579617394318975 0.9366183084611485 0.5890378259937276 0.6431163477315645 0.5586698696061357 0.7182306343377166 0.7683381113690008 0.7845338192950223 0.6435772151126709 1.0 13.045343025131283 -12.790418800992104 19.852642856926483 0.9938972685141978 0.7360776800551008 0.0 0.14097053012910576 0.0 0.0 0.0 0.032720784580344615 1.6202468993009115e-13 12.790418800992104 -0.257819588459097 PAAS(ph)PAVGEK ddPTM_A459_Selumetinib_30min_R2 3 PAASPAVGEK 10 0 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 PAAS(1)PAVGEK;PAAS(1)PAVGEK;PAAS(1)PAVGEK 129.74 0.0028969 21533000.0 261075.0 204885.0 230468.0 236942.0 228828.0 207901.0 234717.0 248948.0 206423.0 240127.0 True False 246565.496666031 220599.0206908903 215639.93979458508 204670.09085225168 200080.5808917246 236537.47561262702 245631.805582912 249672.39746443997 247713.36794052037 233193.90958512752 1.0573410648017896 0.9459896319048613 0.9247237210364005 0.8776819738404738 0.8580008853905556 1.0143381361607942 1.0533371391213115 1.0706643149841655 1.0622634543982055 1.0 17.831170584046944 -6.949041687482965 7.144261180857564 1.0499621319515502 0.9300737173159338 0.5178157619368489 0.05246121988608934 0.17657431446682859 20.0133595579116 0.019852071485148386 0.017439930088130714 1.1244970294669505e-07 6.949041687482965 -0.11988841463561639 PAAS(ph)PLTSLR ddPTM_A459_Selumetinib_30min_R2 1 PAASPLTSLR 10 0 Q92615 Q92615 LARP4B La-related protein 4B 1 PAAS(0.998)PLT(0.002)SLR 170.89 0.00019127 3091000.0 17413.0 7794.8 8188.5 11518.0 12264.0 15779.0 25314.0 25111.0 19560.0 11020.0 True False 16445.25516976195 8392.636095767635 7661.660824964693 9949.228530341748 10723.286678448922 17952.41402249935 26491.151158739398 25184.06885265015 23472.546552063428 10701.823966601429 1.5366777869907777 0.7842248313894551 0.7159210288709132 0.9296759656476875 1.0020055190511892 1.677509747733263 2.475386554797927 2.3532501498104756 2.1933220566248566 1.0 13.385569083027653 -6.893283242620376 3.260039330164776 2.1175503048017874 0.9577168672689846 0.5456537632516112 0.4333019031999003 0.1630452625131136 3.4356736978699227 0.15739287914958403 0.1365936006467555 1.2785471761982502e-07 6.893283242620376 -1.1598334375328028 PAAS(ph)PRPR ddPTM_A459_Selumetinib_30min_R2 2 PAASPRPR 8 1 P20810-6;P20810-7;P20810-10;P20810-9;P20810-5;F8W7E0;E9PSG1 P20810-6;P20810-5 CAST Calpastatin 1 PAAS(1)PRPR;PAAS(1)PRPR 87.806 0.017573 6915400.0 14467.9 10144.6 10879.5 10476.0 10130.0 11778.2 28299.0 61640.0 19741.2 26876.0 True False 13663.832037592541 10922.658199969777 10179.52481470396 9049.150727892013 8857.378836650978 13400.540138145758 29614.959573404703 61819.36219494868 23689.991615214425 26100.020047765884 0.523518066751912 0.4184923298901733 0.39001980826353083 0.346710489544877 0.3393629131487642 0.5134302622611518 1.1346719090332535 2.3685561191835296 0.9076618168054721 1.0 14.671763294497916 -7.347483925793278 3.5470755538339547 1.5157728342376882 0.40764375969794003 0.5945383413464205 0.3774366734470118 0.14664636919177945 3.5125889722860366 0.15940615793320606 0.10385008225373916 4.492789531779633e-08 7.347483925793278 -1.108129074539748 PAAS(ph)SPETPSAGQQEAK ddPTM_A459_Selumetinib_30min_R1 1 PAASSPETPSAGQQEAK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 PAAS(0.67)S(0.33)PETPSAGQQEAK 220.46 6.068e-12 5590300.0 1470.9 1955.5 1204.0 1370.0 1255.4 1241.6 1402.8 2055.6 1007.4 1874.9 True False 1505.1691081268266 1726.5491509127146 1040.5034130985982 1130.7552180850446 1141.8492916588723 1229.1106312826018 1296.9856665992404 2001.078810470173 1709.4842224151234 2115.56167807254 0.7114749353458539 0.8161185602897433 0.4918331731394317 0.5344940919497373 0.5397381241558488 0.5809854867490454 0.6130691815995205 0.9458853557478547 0.8080521783570082 1.0 11.046825031974054 -7.756430897498351 24.830869550935795 0.9077266104106637 0.608704194409159 0.665661622604734 0.0990947500953161 72.2412898804808 358161.06477110804 0.052048567517305584 0.028839349837002586 1.75214120290894e-08 7.756430897498351 -0.2990224160015047 PAAS(ph)SPETPSAGQQEAK ddPTM_A459_Selumetinib_30min_R2 1 PAASSPETPSAGQQEAK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 PAAS(0.613)S(0.387)PETPSAGQQEAK 181.97 7.1407e-08 8798100.0 44318.0 35026.0 39052.0 44835.0 39305.0 35976.0 53365.0 51727.0 40483.0 31640.0 True False 41854.98297901052 37712.381573659004 36539.436836602734 38728.39565531103 34367.154508841704 40931.36744238777 55846.57824074142 51877.517006134185 48580.73118952878 30726.470989407353 1.362179958558847 1.227358051845914 1.189184298099165 1.260424461652699 1.1184868747435863 1.3321206804549228 1.8175396146206955 1.6883656123092836 1.5810709666683331 1.0 14.907194458929286 -7.036231898546363 10.577247651267538 1.5787062159740568 1.2299855354834384 0.2860769823112348 0.20892104308534198 0.7686799004869063 221.97466812892833 0.07495914613042479 0.05861494913051227 9.199582140478737e-08 7.036231898546363 -0.34872068049061844 PAASS(ph)PETPSAGQQEAK ddPTM_A459_Selumetinib_30min_R1 1 PAASSPETPSAGQQEAK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 PAAS(0.096)S(0.903)PET(0.001)PSAGQQEAK 228.51 1.6265e-51 0.0 1177.3 1527.6 866.44 1283.0 1055.8 1064.3 1557.1 1408.5 824.16 1793.3 True False 1204.728799372978 1348.7478818380268 748.7822070142442 1058.948134892782 960.3030764166297 1053.594108307082 1439.6466933715976 1371.142004547207 1398.5393257352073 2023.487523221233 0.5953724871281364 0.6665461814614633 0.37004537879346144 0.5233282255217565 0.4745782049043241 0.5206822855175519 0.7114680356811853 0.6776132735251349 0.6911529276488163 1.0 10.982628238071525 -8.615547599947327 0.5989675049410814 1.0012435284078676 0.5201820683699306 0.7309901393370051 0.08469617898068928 0.5307615091373621 0.43351886045588484 0.09649743790244729 0.040355602583472254 2.4235523215639024e-09 8.615547599947327 -0.4810614600379369 PAASS(ph)PETPSAGQQEAK ddPTM_A459_Selumetinib_30min_R2 1 PAASSPETPSAGQQEAK 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 PAAS(0.167)S(0.833)PETPSAGQQEAK 147.75 0.00037364 10519000.0 36740.0 29640.0 30387.0 37174.0 31083.0 29280.0 42978.0 39952.0 33797.0 29953.0 True False 34698.137881872964 31913.292692378604 28431.933502864038 32110.837071273152 27178.075654454336 33313.054222623796 44976.5621592914 40068.25370559035 40557.34436708013 29088.17906275976 1.192860433339926 1.097122395441924 0.9774394416893603 1.103913620787049 0.9343340329353639 1.1452437139756524 1.5462144282820647 1.3774754899280675 1.3942895593283737 1.0 14.828145365250226 -7.049570009426917 8.105582232258945 1.359640738702543 1.0586899963168104 0.42935683431400373 0.14466562848788705 0.26737096605085636 40.41336082192314 0.05236419320753992 0.040836765660665984 8.921337936524761e-08 7.049570009426917 -0.3009507423857327 PAEKPAETPVATSPT(ph)ATDSTSGDSSR ddPTM_A459_Selumetinib_30min_R1 1 PAEKPAETPVATSPTATDSTSGDSSR 26 1 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 PAEKPAETPVAT(0.029)S(0.292)PT(0.448)AT(0.17)DS(0.025)T(0.025)S(0.01)GDSSR 110.85 2.658e-08 8341600.0 1802.0 2642.2 1697.8 1435.7 1116.4 1696.0 2048.9 1797.0 708.74 1989.0 True False 1843.9830939183767 2332.8499956745454 1467.2480853478412 1184.9819464267875 1015.4218171164289 1678.9397798447908 1894.3498234211454 1749.3377225213571 1202.6800156784734 2244.307524500658 0.8216267484682829 1.0394520225981898 0.6537642766555769 0.5279944630985619 0.45244326191097756 0.7480881124873218 0.8440687395737464 0.7794554460225196 0.5358802225403851 1.0 11.132054658324613 -5.273764971170363 24.629972268752198 0.6777547605088563 0.9305393850440765 0.25121399775867426 0.16260794372237433 716.7176026018707 1432203.071988198 0.04350491122132293 0.09163919977972268 5.323963002909099e-06 5.273764971170363 0.2527846245352202 PAGPAGDEPAES(ph)PSETPGPR ddPTM_A459_Selumetinib_30min_R2 1 PAGPAGDEPAESPSETPGPR 20 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 PAGPAGDEPAES(0.994)PS(0.005)ET(0.001)PGPR 188.16 1.3392e-15 4400000.0 10479.0 6630.9 7971.5 11615.0 9205.3 10238.0 19605.0 15877.0 14667.0 7644.2 True False 9896.619130760657 7139.468708295994 7458.62236871296 10033.01696300741 8048.847917573868 11648.191568689297 20516.67134657052 15923.199441421146 17600.80983022055 7423.492083983183 1.3331487416971126 0.9617399234115176 1.004732312546756 1.351522551583843 1.0842401159071675 1.5690986717452375 2.763749339860817 2.144974260264493 2.370960948176371 1.0 12.85788228917578 -7.019042771246486 5.374844374282487 2.170884409520598 1.1525853101956578 0.4927926222580319 0.43612427462517184 0.13148859216437495 11.692607085757158 0.15455422359399526 0.1253996471860678 9.5709980721981e-08 7.019042771246486 -1.0182990993249401 PAGSYLEAQAGPYAT(ph)GPASHISPR ddPTM_A459_Selumetinib_30min_R1 1 PAGSYLEAQAGPYATGPASHISPR 24 0 J3KPJ3;Q8N5S9;Q8N5S9-2 J3KPJ3 CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 1 PAGSYLEAQAGPY(0.009)AT(0.714)GPAS(0.199)HIS(0.077)PR 104.79 8.954200000000002e-07 6360600.0 1318.2 1751.8 1228.3 1157.0 1031.3 1232.8 1502.6 1120.6 710.67 1288.0 True False 1348.911495229304 1546.6984416102737 1061.5036065689446 954.9516695798512 938.0190970908035 1220.3991512928408 1389.257672249799 1090.8780477782043 1205.9550847168503 1453.3273461824278 0.9281539350185617 1.0642464312483428 0.7303953987773517 0.6570795437712638 0.6454286431441436 0.839727646010764 0.9559151803611721 0.7506072535163545 0.8297890271483777 1.0 10.505143975605487 -5.263117822892757 24.993613142592846 0.7884137961199532 0.9962001890545649 0.31614775348054214 0.11354292767965272 158.8172838043395 2364980.430917999 0.03064078461733995 0.06964206946955133 5.45609818574443e-06 5.263117822892757 0.20778639293461165 PAMEPGNGS(ph)LDLGGDSAGR ddPTM_A459_Selumetinib_30min_R2 1 PAMEPGNGSLDLGGDSAGR 19 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 PAMEPGNGS(1)LDLGGDSAGR 114.1 0.0014727 0.0 11075.0 12352.0 12501.0 9435.2 9305.3 7864.8 9980.6 11168.0 10312.0 9834.8 True False 10459.4958367377 13299.35868206007 11696.699270059684 8150.1094833721545 8136.285023562521 8948.104810453948 10444.717676183709 11200.497031038078 12374.688141353685 9550.843770120842 1.095138407504844 1.3924799737240179 1.2246770601202799 0.8533392106013933 0.8518917510740076 0.9368915486239529 1.093591092847659 1.1727233007494124 1.2956643872729912 1.0 13.221412478459273 -5.604135653202595 9.3397129295253 1.0280683317031132 1.2598769979748228 0.29962781435407926 0.1456828199201493 0.379734831493172 39.874871042660224 0.04349884756412705 0.07543829984030936 2.4880800375269636e-06 5.604135653202595 0.2318086662717096 PAMPQDSVPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 PAMPQDSVPSPR 12 0 P53396 P53396 ACLY ATP-citrate synthase 1 PAMPQDS(0.229)VPS(0.771)PR 85.163 0.031636000000000004 7579700.0 1796.5 1659.3 1259.6 1373.7 1479.4 955.35 1338.3 1250.3 536.52 1396.9 True False 1838.3549546195154 1465.0283846123575 1088.5532384875376 1133.8090825426464 1345.5885312092846 945.7400463883974 1237.3509535284877 1217.1379824532296 910.4352541296032 1576.205721958256 1.1663166355820414 0.9294652114269873 0.6906162205369577 0.7193281097431989 0.8536883938839812 0.6000105400032575 0.7850186915900929 0.7721948762760957 0.577611945855958 1.0 10.622240128263337 -4.919193591008828 2.5796009365971853 0.7405418223019002 1.1962226320590463 0.555923786315839 0.11578057842686419 0.24781962240400932 2.6748817296309917 0.0282906643102691 0.2183992992451819 1.2044989035304956e-05 4.919193591008828 0.4556808097571461 PAMPQDSVPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 PAMPQDSVPSPR 12 0 P53396 P53396 ACLY ATP-citrate synthase 1 PAMPQDS(0.055)VPS(0.945)PR;PAMPQDS(0.008)VPS(0.992)PR 86.189 0.03023 58730000.0 157321.0 99532.0 132100.0 140536.0 132954.0 99159.0 135718.0 114085.0 113117.0 143713.0 True False 148577.7286258611 107165.78435417775 123600.82981960506 121394.75436187799 116251.12989615936 112817.25217421965 142029.15592011527 114416.9684622115 135743.56075305483 139563.6322787835 1.064587716727461 0.7678632506505 0.8856234808557278 0.8698165301357841 0.8329614814262173 0.8083570936937428 1.0176659463577644 0.819819365503897 0.972628460127077 1.0 17.09056352510693 -8.424759720781465 5.776962332057524 0.999322354189941 0.8796403926248231 0.18285813265398487 0.0876206379638494 0.3270353843994146 14.4220181021014 0.07920997442088187 0.020552853468127085 3.760453988811635e-09 8.424759720781465 -0.1196819615651179 PAPAVGEAEDKENQQAT(ph)SGPNQPSVR ddPTM_A459_Selumetinib_30min_R2 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989-2;P16989;P16989-3 P16989-2 YBX3 Y-box-binding protein 3 1 PAPAVGEAEDKENQQAT(0.369)S(0.369)GPNQPS(0.262)VR 53.342 0.021429 6969300.0 17817.0 19944.0 16097.0 16071.0 13875.0 10911.0 12433.0 16961.0 12707.0 15132.0 True False 16826.80246710208 21473.640669932498 15061.336545088448 13882.102075978666 12131.898455926184 12413.891209803567 13011.159135522114 17010.353701955304 15248.755063244871 14695.099842342359 1.145062139599586 1.461278990977557 1.0249223691349696 0.9446755874348586 0.8255744150148212 0.8447639922822618 0.885408011862012 1.1575527818424063 1.0376761796001694 1.0 13.843047540618509 -5.415135752325337 5.462409073457155 0.9523253614304911 1.2999750294712449 0.580701121021702 0.1159630289297417 0.15444006786871592 6.492029286191855 0.032406069342696686 0.0688000336539329 3.844715846402982e-06 5.415135752325337 0.3476496680407538 PAPAVGEAEDKENQQATSGPNQPS(ph)VR ddPTM_A459_Selumetinib_30min_R2 2 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989-2;P16989;P16989-3 P16989-2 YBX3 Y-box-binding protein 3 1 PAPAVGEAEDKENQQATS(0.001)GPNQPS(0.999)VR;PAPAVGEAEDKENQQAT(0.015)S(0.056)GPNQPS(0.93)VR 99.319 1.3185e-06 27079900.0 91398.0 92060.0 102724.0 104054.0 91114.0 52357.0 83402.0 82890.0 67933.0 82240.0 True False 86318.46505518298 99120.70598044433 96114.84967743471 89881.6656968381 79667.44475050514 59568.70150047521 87280.35825792782 83131.19617682179 81521.49820661165 79865.51751481877 1.0807976676438225 1.2410951442473634 1.2034586723813683 1.1254126748776263 0.9975199213568373 0.7458625869346235 1.0928415788670405 1.0408897201648644 1.02073461417796 1.0 16.285285123650375 -6.180486687281239 3.5040836454787354 0.9780057908999479 1.178757954300542 0.47360923531340227 0.09375739752223103 0.22194898509623026 5.250264902282035 0.030262030295464537 0.03964053651607313 6.599534639477307e-07 6.180486687281239 0.2007521634005941 PAPPPQS(ph)QSPEVEQLGR ddPTM_A459_Selumetinib_30min_R1 1 PAPPPQSQSPEVEQLGR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 PAPPPQS(0.5)QS(0.5)PEVEQLGR 147.37 0.00039029 7707500.0 639.48 714.45 433.09 474.95 456.69 549.24 776.49 623.86 196.97 606.81 True False 654.3786397885262 630.8018618612057 374.27875679308295 392.0088984156877 415.3824701351684 543.7151442700193 717.9187341443142 607.3132062171252 334.2437038803921 684.6999743299366 0.9557158818779224 0.9212821462108614 0.5466317669419528 0.5725265271103841 0.6066634813907673 0.7940925436752231 1.048515789484126 0.8869771125834437 0.48816082431942664 1.0 9.419328148116744 -6.995458527330705 24.606375889192964 0.8571819011333979 0.7124827751006785 0.10245666282548072 0.18844668443656462 258.8403552246268 1402420.752288518 0.07091229172903493 0.06229463560384515 1.0105119941069759e-07 6.995458527330705 -0.1446991260327194 PAPPPQSQS(ph)PEVEQLGR ddPTM_A459_Selumetinib_30min_R2 2 PAPPPQSQSPEVEQLGR 17 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 PAPPPQS(0.282)QS(0.718)PEVEQLGR;PAPPPQS(0.216)QS(0.784)PEVEQLGR 186.96 6.2399e-08 13499000.0 27593.9 19799.4 30463.3 42992.0 40838.0 39997.0 30424.3 40812.0 27371.7 37970.0 True False 26060.341505133743 21317.950314894788 28503.324443933187 37136.41543466334 35707.56534364786 45506.22369338405 31839.09023460673 40930.75616320968 32846.80482919807 36873.70744209221 0.7067458987154963 0.5781341718451626 0.7729986058140703 1.007124534276454 0.9683746989565479 1.234110341761773 0.8634632219884041 1.1100255168940851 0.8907920333419651 1.0 15.170304858075584 -5.640303901339592 2.927680309415114 1.0190511811950973 0.6438439227673327 0.6827082167121727 0.1036583136939402 0.13320867780417658 2.2788324426596236 0.027926940657022815 0.05407558287833105 2.2892651589551722e-06 5.640303901339592 -0.3752072584277646 PAPPQEES(ph)PSSEAK ddPTM_A459_Selumetinib_30min_R2 3 PAPPQEESPSSEAK 14 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 PAPPQEES(0.527)PS(0.428)S(0.046)EAK;PAPPQEES(0.563)PS(0.398)S(0.039)EAK;PAPPQEES(0.964)PS(0.029)S(0.007)EAK 203.52 3.4485e-05 130682000.0 158730.0 118926.0 121340.0 111234.0 104279.0 102465.0 151693.0 130424.0 96011.0 119677.0 True False 149908.4220465348 128047.24179263902 113533.11650500308 96083.73731064721 91178.53975391184 116578.62366533984 158747.02507397722 130803.51224714446 115215.88277148078 116221.6140518112 1.2898497690774295 1.1017506755288737 0.976867490881605 0.8267286433297459 0.7845230897693846 1.0030718005118178 1.3658993326594857 1.1254663197917103 0.9913464350969858 1.0 16.82651887007801 -9.225697176623719 16.441909817892338 1.0000158140234396 1.0464946477180588 0.007220332592139056 0.17240412568925276 0.0 0.0 0.18530018730156828 0.04494189674653544 5.94706689131023e-10 9.225697176623719 0.04647883369461914 PAPPQEESPS(ph)SEAK ddPTM_A459_Selumetinib_30min_R1 3 PAPPQEESPSSEAK 14 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 PAPPQEES(0.466)PS(0.487)S(0.047)EAK;PAPPQEES(0.022)PS(0.961)S(0.017)EAK;PAPPQEES(0.095)PS(0.825)S(0.08)EAK 217.79 1.1375e-08 55825000.0 5241.0 8473.3 4869.0 5420.4 4450.4 4914.2 6469.500000000001 5477.0 2952.5499999999997 5861.299999999999 True False 5363.105102789245 7481.242096869696 4207.816543502557 4473.828893509618 4047.8621057819373 4864.767609736603 5981.5004063756705 5331.732168196704 5010.2617042801 6613.654948896787 0.8109139566895391 1.1311811932549687 0.6362316413565627 0.6764533269543931 0.6120461586005715 0.7355641694836358 0.9044167638914146 0.8061702960608917 0.7575632147419263 1.0 12.691232063105982 -9.881208415124526 15.163908015035387 1.0000092629463728 0.7856966395382414 0.16980040214064263 0.14221190500973163 0.0 0.0 0.1467497946524933 0.03559205316999599 1.314593815689268e-10 9.881208415124526 -0.2143126234081314 PAPPQEESPS(ph)SEAK ddPTM_A459_Selumetinib_30min_R2 1 PAPPQEESPSSEAK 14 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 PAPPQEES(0.172)PS(0.458)S(0.37)EAK 188.0 9.073e-05 21965000.0 19242.0 18879.0 16115.0 19614.0 16160.0 15788.0 21087.0 19377.0 16307.0 17967.0 True False 18172.606671829064 20326.958594447227 15078.17844468535 16942.539363962765 14129.836327767009 17962.65369080549 22067.5872830978 19433.383861964958 19568.855655649182 17448.246026127752 1.0415148115527844 1.1649857850473204 0.8641658549579505 0.9710167622918819 0.8098141387167733 1.0294819126178898 1.2647453073536932 1.113772916364463 1.12153712335016 1.0 14.090794397268676 -7.010097833707737 24.960866197113187 1.1362975971394518 0.9696978260422472 0.31302401885186015 0.10760932970824155 571.0546849855381 1411592.1773554345 0.04066335377998224 0.033741654881830487 9.770171030939216e-08 7.010097833707737 -0.16659977109720459 PAPPQEESPSS(ph)EAK ddPTM_A459_Selumetinib_30min_R1 1 PAPPQEESPSSEAK 14 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 PAPPQEES(0.101)PS(0.251)S(0.647)EAK 188.12 9.13e-05 25300000.0 1690.3 2086.7 1220.9 1303.6 1137.9 1433.1 1677.7 1292.0 748.93 1599.0 True False 1729.6807012487425 1842.3881939194891 1055.108485923654 1075.9507316026738 1034.9771459125616 1418.6843151506907 1551.1497382759808 1257.7319629925391 1270.8795103170123 1804.247225578961 0.9586716702272933 1.0211395466207738 0.5847915246676255 0.5963432928419299 0.5736337743739359 0.7863026169794731 0.8597212822528996 0.6970951348360523 0.7043821336120956 1.0 10.817181320971201 -5.248875440840934 24.680593993854387 0.7114251919742443 0.9899056594076371 0.40648647704829344 0.12702215581506124 608.3686506222308 1195072.506428899 0.03282339230063246 0.08553387691743233 5.637993348344903e-06 5.248875440840934 0.27848046743339283 PAPS(ph)RDPSPPR ddPTM_A459_Selumetinib_30min_R2 1 PAPSRDPSPPR 11 1 Q5C9Z4 Q5C9Z4 NOM1 Nucleolar MIF4G domain-containing protein 1 1 PAPS(0.995)RDPS(0.005)PPR 74.53699999999998 0.030239 3520500.0 18587.0 13737.0 15069.0 19163.0 15387.0 12166.0 12191.0 11891.0 8503.7 18659.0 True False 17554.00894965631 14790.583728583175 14099.476945886663 16552.966341981162 13453.94749847468 13841.756068047853 12757.905656008219 11925.600841338983 10204.677613230151 18120.26618809583 0.968750059598378 0.8162453892813064 0.7781053986474747 0.913505694130238 0.7424806765428918 0.7638826010812823 0.7040683356180257 0.6581360735844789 0.5631637806697425 1.0 14.145316528389728 -6.531339232698361 1.6509143773642228 0.7074851456701624 0.8609184698283138 0.2008856523837107 0.11699783772570681 0.5304551277913873 2.940222134272782 0.04448396756020911 0.04844490663023071 2.942122608288488e-07 6.531339232698361 0.15343332415815136 PARPPS(ph)PTEQEGAVPR ddPTM_A459_Selumetinib_30min_R2 1 PARPPSPTEQEGAVPR 16 1 Q8N8E2;Q8N8E2-2 Q8N8E2 ZNF513 Zinc finger protein 513 1 PARPPS(0.978)PT(0.022)EQEGAVPR 125.41 0.004609 0.0 6691.6 7295.0 8610.1 8883.7 8952.7 7038.1 7050.0 7121.1 6899.8 6949.5 True False 6319.7076605972 7854.503042877934 8056.135539968069 7673.72473476272 7827.981787846517 8007.534389489368 7377.838969309982 7141.8212220384285 8279.952796519792 6748.849878030548 0.9364125406270586 1.1638283833289291 1.193704955001757 1.1370418476402782 1.159898638926442 1.1865035575255867 1.0931994491871828 1.058227898250799 1.2268687178052997 1.0 12.72042594732356 -10.303133189360407 14.966764039964353 0.9999948898771195 1.1311606674857164 0.19055385374284128 0.07921449935449529 0.0 0.0 0.07468998970751263 0.018114983337668856 4.97584462455755e-11 10.303133189360407 0.13116577760859693 PAS(ph)LGTGK ddPTM_A459_Selumetinib_30min_R1 2 PASLGTGK 8 0 Q9BW04-2;Q9BW04 Q9BW04-2 SARG Specifically androgen-regulated gene protein 1 PAS(0.593)LGT(0.407)GK;PAS(0.999)LGT(0.001)GK 92.538 0.025323 21660000.0 6150.0 8473.6 5619.1 6192.8 5774.5 7361.8 6446.9 7120.3 4006.6 6927.599999999999 True False 6293.283034183145 7481.506972730235 4856.057083506921 5111.343733253334 5252.19749457078 7287.74697597959 5960.605142571035 6931.446514006018 6798.907569514029 7816.824940538339 0.8050945341689756 0.957103047546948 0.6212313977153603 0.6538900093240824 0.6719093154220062 0.9323154901659712 0.7625353244971778 0.8867342644529858 0.8697786660482374 1.0 12.932367013332447 -8.217441270163752 0.729263323713393 0.9921213931750799 0.7573922364700428 0.32987839671496744 0.1045594807602745 0.8233498376960079 0.962960565536718 0.10757198944609997 0.04456531713078814 6.061201608845317e-09 8.217441270163752 -0.23472915670503702 PAS(ph)LGTGK ddPTM_A459_Selumetinib_30min_R2 1 PASLGTGK 8 0 Q9BW04-2;Q9BW04 Q9BW04-2 SARG Specifically androgen-regulated gene protein 1 PAS(0.979)LGT(0.021)GK 86.882 0.03325 12163000.0 57155.0 43758.0 46577.0 45056.0 45854.0 37304.0 75906.0 76796.0 53338.0 68354.0 True False 53978.553909593036 47114.09789585372 43580.28652920322 38919.29507406473 40093.41058003888 42442.28738800402 79435.7794048855 77019.4636457377 64007.09038823917 66380.44241497961 0.8131695412956764 0.7097587208189775 0.6565229899608015 0.5863066538598737 0.6039943260605819 0.6393793991711385 1.1966744498069175 1.160273430602464 0.9642462155961037 1.0 16.018470624328273 -7.254953288237176 24.999627038345423 1.0936546482542155 0.6629080565257899 0.8438262199603446 0.08676138051390482 192.60111964861477 742352.6855439531 0.03537463803168915 0.026724496833071928 5.5596405232984344e-08 7.254953288237176 -0.43074659172842567 PAS(ph)LYQSSIDRSLERPMS(ph)S(ph)ASMASDFRK ddPTM_A459_Selumetinib_30min_R2 1 PASLYQSSIDRSLERPMSSASMASDFRK 28 3 H7BZK1;O94875-9;O94875-7;O94875;O94875-11 H7BZK1 SORBS2 Sorbin and SH3 domain-containing protein 2 3 PAS(0.688)LY(0.096)QS(0.101)S(0.101)IDRS(0.023)LERPMS(0.494)S(0.494)AS(0.502)MAS(0.501)DFRK 40.669 0.041357 9151000.0 6560.2 8333.6 9359.7 15013.0 16365.0 8981.1 10416.0 12264.0 11053.0 13220.0 True False 6195.6103465613205 8972.760323252576 8757.507092070839 12968.203501130454 14309.082395043759 10218.165002691483 10900.364638912439 12299.686209585503 13263.908846623566 12838.304250314966 0.48258790458321793 0.6989054121405827 0.6821389274877161 1.0101181003567743 1.1145617143862836 0.7959123575405839 0.8490501881231718 0.9580460136924821 1.0331511536111289 1.0 13.648167035964187 -5.6588943436099575 4.197664799431824 0.9582010955080964 0.6120805924912653 0.7193340408761963 0.09921514924808363 0.12664990916830732 4.00587742590199 0.029434706001470873 0.05265372647766542 2.193338472035415e-06 5.6588943436099575 -0.34612050301683106 PAS(ph)PDRFAVSAEAENK ddPTM_A459_Selumetinib_30min_R1 3 PASPDRFAVSAEAENK 16 1 O15037;G3V331 O15037 KHNYN Protein KHNYN 1 PAS(1)PDRFAVSAEAENK;PAS(1)PDRFAVSAEAENK;PAS(0.994)PDRFAVS(0.006)AEAENK 141.6 0.0018823 30693100.0 5891.0 6731.200000000001 4869.07 5272.74 4250.0 5393.3099999999995 5533.0 5485.629999999999 3049.3599999999997 5891.0 True False 6028.248838109415 5943.107974750022 4207.877037887037 4351.95494058813 3865.588250398442 5339.058198133673 5115.641355356145 5340.1332725625125 5174.5412035574545 6647.167233199287 0.9068899016112183 0.8940813080596438 0.6330331237750103 0.654708206956534 0.5815391902721743 0.8032080449951279 0.7695972097416275 0.8033697792183125 0.7784581043355131 1.0 12.698523935153494 -9.14848173108828 0.772753592996791 1.0028026802827956 0.7417783288362876 0.34589133933777294 0.10079914069173558 2.8017790191201857 2.4160492795626185 0.13014203269738134 0.03879053100574771 7.104250539184999e-10 9.14848173108828 -0.26102435144650804 PAS(ph)PDRFAVSAEAENK ddPTM_A459_Selumetinib_30min_R2 3 PASPDRFAVSAEAENK 16 1 O15037;G3V331 O15037 KHNYN Protein KHNYN 1 PAS(1)PDRFAVSAEAENK;PAS(1)PDRFAVSAEAENK;PAS(0.995)PDRFAVS(0.005)AEAENK 110.32 0.013372 62002000.0 129766.0 106110.0 102591.0 99074.0 96636.0 91350.0 99649.0 89983.0 65520.0 88135.0 True False 122554.12521445644 114248.2958025741 95990.4067526353 85579.95028781726 84495.72174319888 103932.63330726385 104282.87595074743 90244.83563251238 78625.83078175831 85590.31354776936 1.4318690998375296 1.3348274012200019 1.121510165972946 0.9998789201777335 0.9872112653967605 1.214303686938328 1.2183957696631809 1.054381411772084 0.9186300122370267 1.0 16.385159912305127 -5.2123350075036905 2.6542400543693905 1.0679402213564366 1.4194683868326103 0.6708343050627807 0.0911944489870957 0.1899314438781736 2.5504542350464545 0.02700460144512549 0.09433144541809689 6.132887419707575e-06 5.2123350075036905 0.3515281654761737 PAS(ph)PSLQLLPWR ddPTM_A459_Selumetinib_30min_R1 1 PASPSLQLLPWR 12 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 PAS(0.727)PS(0.273)LQLLPWR 100.73 0.013183000000000002 17554000.0 1076.2 1167.5 1276.6 1277.3 937.7 838.28 1029.0 1042.8 641.42 1003.4 True False 1101.273366079333 1030.8085572439754 1103.2447318618533 1054.2435328905308 852.8852005643811 829.8476642973421 951.3817015473476 1015.1415565082206 1088.442892536736 1132.1961639436706 0.9726877736834691 0.9104504944209125 0.9744289611607819 0.9311491828574875 0.7533016165622816 0.7329539621533544 0.8402975843280467 0.8966127856963187 0.9613553968823451 1.0 10.144908225367804 -6.026921992670732 24.300625349264426 0.850358129443107 0.9490608774494942 0.20034242877815622 0.07927800915761234 752.6568777859454 679370.8033213149 0.024628299475105885 0.03190404434796331 9.398921174287636e-07 6.026921992670732 0.09870274800638723 PAS(ph)PSLQLLPWR ddPTM_A459_Selumetinib_30min_R2 1 PASPSLQLLPWR 12 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 PAS(0.658)PS(0.342)LQLLPWR 133.04 0.0017982 11906000.0 16416.0 15694.0 20287.0 16799.0 20627.0 13784.0 18887.0 13928.0 14607.0 11202.0 True False 15503.664438454716 16897.679335836376 18981.756506815513 14510.94722010862 18035.65185228033 15682.620881306231 19765.2829238805 13968.52817409547 17528.80815368049 10878.56915370864 1.4251565825795502 1.5532998041452672 1.7448762092342258 1.3339021901755945 1.657906623329388 1.441606948461584 1.816900977013348 1.2840409411134206 1.6113155973002846 1.0 13.409201192516491 -10.855876195012488 4.31782260085895 0.9992850558262325 1.5423397445185132 0.49503413901847015 0.16391517932495445 110238181.73447011 860.3705621567923 783583.2640180137 0.03669972509708185 1.3935540088842424e-11 10.855876195012488 0.5430546886922807 PAS(ph)PVAGSPK ddPTM_A459_Selumetinib_30min_R1 2 PASPVAGSPK 10 0 Q13057-2;K7EN91;Q13057 Q13057-2 COASY Bifunctional coenzyme A synthase;Phosphopantetheine adenylyltransferase;Dephospho-CoA kinase 1 PAS(0.999)PVAGS(0.001)PK;PAS(1)PVAGSPK 131.12 0.0026642 23459000.0 8470.6 11636.2 6305.9 6630.7 6788.4 7138.9 10007.8 9904.8 4701.8 10109.5 True False 8667.948499081578 10273.828294477378 5449.593415829282 5472.772718654385 6174.39041858936 7067.0891476025845 9252.903588673997 9642.092528675317 7978.611194114978 11407.152799868982 0.7598695880694379 0.9006479070391149 0.47773476093805584 0.4797667581622334 0.5412735786847948 0.6195313827727243 0.8111492631868903 0.845267236955576 0.6994393197053184 1.0 13.477651122613738 -7.280617754132688 5.752130723610503 0.8276314111033363 0.6240158461541536 0.3538579684108243 0.13807652334403686 0.23559684558543495 28.299232826563106 0.06249428059030866 0.0434241137530509 5.24061488282186e-08 7.280617754132688 -0.20361556494918265 PAS(ph)PVAGSPK ddPTM_A459_Selumetinib_30min_R2 3 PASPVAGSPK 10 0 Q13057-2;K7EN91;Q13057 Q13057-2 COASY Bifunctional coenzyme A synthase;Phosphopantetheine adenylyltransferase;Dephospho-CoA kinase 1 PAS(1)PVAGSPK;PAS(1)PVAGSPK;PAS(0.991)PVAGS(0.009)PK 110.93 0.0091576 45051900.0 204067.0 147209.0 174576.0 209776.0 204409.0 164097.0 255522.0 254484.0 205222.0 154904.0 True False 192725.77308492587 158499.4569484601 163343.9702239772 181204.1469162154 178729.31398035414 186699.87222574803 267404.2793072373 255224.50630790612 246272.13438177717 150431.5190310732 1.2811528749178978 1.053631964692987 1.0858360752857703 1.2045623688662332 1.1881108103643874 1.2410954394948523 1.7775814605182718 1.6966158950717425 1.637104617223915 1.0 17.198747352527583 -7.115736621426577 5.45755909996078 1.5839353533965812 1.160047749731108 0.4024155652911847 0.20718201226755076 0.19243652307346137 7.914083676469566 0.07612527517991596 0.058834465884410055 7.660610449962168e-08 7.115736621426577 -0.4238876036654733 PASHSHAHQHS(ph)PISPR ddPTM_A459_Selumetinib_30min_R2 1 PASHSHAHQHSPISPR 16 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 PASHS(0.001)HAHQHS(0.902)PIS(0.097)PR 56.719 0.033874 877610.0 0.0 0.0 0.0 826.93 521.91 662.89 0.0 0.0 762.37 0.0 True False 0.0 0.0 0.0 714.3007074661839 456.342999865401 754.1970803837127 0.0 0.0 914.8653023975755 0.0 0.0 PASHSHAHQHSPIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 PASHSHAHQHSPISPR 16 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 PASHSHAHQHS(0.003)PIS(0.997)PR;PASHSHAHQHS(0.028)PIS(0.972)PR 77.969 0.010516 1933420.0 653.83 0.0 1778.52 1306.15 1730.5 1019.44 612.37 1299.65 0.0 1770.5500000000002 True False 617.4927460888679 0.0 1664.0919595061623 1128.2501167655728 1513.0991191337132 1159.8586064450692 640.8464183881352 1303.4317663313607 0.0 1719.4296210586353 0.3591265024902176 0.0 0.9678162683283296 0.6561769687734708 0.8800006121809821 0.6745600937890996 0.37270872302035407 0.7580605512244526 0.0 1.0 10.747714349972757 -5.251168228630233 24.97997327930704 0.6524813109328131 0.17956324351402866 0.30501124774152155 0.2919090846534451 837.9173768785739 2037848.8240804963 0.07194221963493909 0.1857953725145124 5.608306901621616e-06 5.251168228630233 -0.4729180674187845 PASPS(ph)LQLLPWR ddPTM_A459_Selumetinib_30min_R1 1 PASPSLQLLPWR 12 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 PAS(0.17)PS(0.83)LQLLPWR 111.88 0.0066133 19471000.0 1841.5 2153.9 2556.9 2678.5 1535.1 1569.5 1770.1 1568.8 1336.2 1765.5 True False 1884.4033670647575 1901.7203866790564 2209.6870240463513 2210.7502566721114 1396.2504760439174 1553.7122549919814 1636.5799318843135 1527.1903278194238 2267.4338078132696 1992.1191224263011 0.9459290590864108 0.9546218221944762 1.1092143030859838 1.109748022487495 0.7008870405015512 0.7799293915213452 0.8215271433623113 0.7666159672014907 1.1382019188951156 1.0 10.96008820325047 -6.247446603727448 24.973480113495 0.84947783834359 1.0301696952422332 0.2686708966647884 0.12882810669931696 1000.995360386911 1786517.0828257347 0.03850343244956793 0.04944113760353677 5.656573000741983e-07 6.247446603727448 0.1806918568986432 PASTSQPDPS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 2 PASTSQPDPSPDR 13 0 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 PASTSQPDPS(1)PDR;PASTSQPDPS(1)PDR 157.37 0.00036494 9412400.0 55637.0 41273.0 44827.0 50807.0 52405.0 43970.0 53687.0 60697.0 43596.0 52423.0 True False 52544.91827255762 44438.50638638806 41942.8796239473 43886.99895303639 45821.415393355805 50026.46838008086 56183.55187877228 60873.61822107073 52316.4181740162 50909.411778688445 1.0321258179328212 0.8728937309189414 0.823872799911338 0.8620606174712913 0.9000578437745265 0.9826565782679658 1.1035985275770106 1.1957242500796967 1.0276374514293005 1.0 15.635644775953152 -7.021913147623652 2.664606075073294 1.0977308493011195 0.8904308155202992 0.5942123261723202 0.07075019156533258 0.18062246013559882 2.569724965235701 0.029529871422221292 0.023324325764273707 9.507949193541593e-08 7.021913147623652 -0.2073000337808203 PASVDGSPVS(ph)PSTNR ddPTM_A459_Selumetinib_30min_R1 2 PASVDGSPVSPSTNR 15 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 PASVDGS(0.039)PVS(0.477)PS(0.242)T(0.242)NR;PASVDGS(0.009)PVS(0.981)PS(0.008)T(0.002)NR 176.43 1.9283e-05 17819600.0 3782.2599999999998 4313.3 2491.41 3299.0 3151.2 2645.16 3604.1 3325.0 1842.62 4322.1 True False 3870.3792990031748 3808.2968308012323 2153.090206335532 2722.8915798996813 2866.1745163895466 2618.552092013119 3332.2398353224426 3236.810198877859 3126.791560359893 4876.883635819156 0.7936173154873888 0.7808873688989637 0.44148894398910216 0.5583261326763901 0.5877061522113033 0.536931427434661 0.6832723690284925 0.6637046197092996 0.641145410440923 1.0 12.251743834228929 -9.659699937039044 0.7915925705289739 1.012579142484433 0.6195953350231218 0.5384924676381975 0.10228052333898753 6.480915651976452 3.707973379120767 0.37005590727080967 0.03727553932441541 2.1892737156139425e-10 9.659699937039044 -0.39298380746131123 PASVDGSPVS(ph)PSTNR ddPTM_A459_Selumetinib_30min_R2 3 PASVDGSPVSPSTNR 15 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 PASVDGS(0.011)PVS(0.688)PS(0.151)T(0.151)NR;PASVDGS(0.019)PVS(0.964)PS(0.014)T(0.004)NR;PASVDGS(0.04)PVS(0.955)PS(0.004)T(0.001)NR 168.1 6.832399999999999e-05 29988000.0 107528.0 81695.0 91319.0 90420.0 95703.0 74870.0 93144.0 100377.0 80552.0 79260.0 True False 101552.02422868909 87960.74380917258 85443.63496060949 78104.64001679972 83679.93354432458 85182.66289780888 97475.38056133447 100669.08045169318 96664.6508109311 76971.5578577886 1.3193447950776176 1.1427694366234267 1.1100676319748362 1.0147207902574167 1.0871539549573657 1.1066771320283135 1.2663818074389035 1.3078737556239635 1.2558489590340256 1.0 16.23203782642448 -7.255867050845404 24.562841762465826 1.2331822774912882 1.1225869530097337 0.09095683077624439 0.10676620524258665 612.1919646971047 2698552.5811154684 0.041723029558965695 0.03137871393904755 5.547955247108036e-08 7.255867050845404 -0.11059532448155451 PAT(ph)PGASSVEQLRK ddPTM_A459_Selumetinib_30min_R1 2 PATPGASSVEQLRK 14 1 Q9H3U1 Q9H3U1 UNC45A Protein unc-45 homolog A 1 PAT(1)PGASSVEQLRK;PAT(1)PGASSVEQLRK 170.26 0.00075181 61126000.0 7362.7 10849.8 9239.5 9352.4 7750.299999999999 8805.5 9055.2 9721.1 4942.3 10217.1 True False 7534.236584679711 9579.500372064818 7984.826648940621 7719.178906290927 7049.2867334266 8716.924664754315 8372.158973616657 9463.264849417008 8386.722128689957 11528.564307981731 0.6535277406106351 0.8309361093152345 0.6926124047737996 0.6695698354171127 0.6114626717696383 0.7561153697793233 0.7262100249395533 0.8208537157454354 0.7274732485885914 1.0 13.492925239918094 -9.470262004333346 0.5042256810536623 1.026076594833041 0.7018875603572141 0.6507296402383089 0.06294287807463324 2.491788813709737 0.8151964888683598 0.2008522514432344 0.03235877328371288 3.386397974222278e-10 9.470262004333346 -0.3241890344758269 PAT(ph)PGASSVEQLRK ddPTM_A459_Selumetinib_30min_R2 2 PATPGASSVEQLRK 14 1 Q9H3U1 Q9H3U1 UNC45A Protein unc-45 homolog A 1 PAT(0.994)PGAS(0.006)SVEQLRK;PAT(0.986)PGAS(0.013)S(0.001)VEQLRK 93.738 0.017542 72785000.0 396250.0 318130.0 313690.0 328820.0 305590.0 255070.0 303260.0 291050.0 211830.0 305560.0 True False 374228.01131443045 342529.5480508236 293507.5269198482 284034.1487538607 267199.05219073733 290203.5772050773 317362.1908982902 291896.9073140784 254201.91902472384 296737.6888597758 1.261140816835279 1.1543176377999187 0.9891144197006468 0.9571893271976039 0.9004553928335103 0.9779801760949004 1.0695041540485293 0.9836866642579235 0.8566553173663345 1.0 18.178828650590816 -5.105511570079377 2.174130804411545 0.964665996939545 1.26692945025538 0.7738473713344958 0.053749725241779546 0.18214213153378006 1.477919243302488 0.015616456723418135 0.08158874588874751 7.843112236959262e-06 5.105511570079377 0.30226345331583504 PAT(ph)PHLLHHR ddPTM_A459_Selumetinib_30min_R2 2 PATPHLLHHR 10 0 Q9UPT8 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 PAT(1)PHLLHHR;PAT(1)PHLLHHR 131.12 0.0020841 10080100.0 29910.0 17861.4 20646.5 22972.2 24243.1 20379.3 29326.0 25183.0 21350.8 20115.9 True False 28247.721939216648 19231.311946546943 19318.126668209523 19843.346730744637 21197.465041936153 23186.36359013379 30689.717108366596 25256.27836072993 25621.556591196095 19535.101699615036 1.445998202291074 0.9844490314030933 0.9888930687568528 1.0157790338575854 1.0850962215545505 1.1869077492742568 1.571003702989239 1.292866489721302 1.3115650476342797 1.0 14.25378114575178 -7.008830588317672 18.642531022621103 1.326934590949779 1.0910873898906361 0.1889328223933715 0.17925879700320632 19.585975924939806 41349.25662863497 0.06387459532427599 0.05328610798223338 9.798721441100811e-08 7.008830588317672 -0.2358472010591428 PAT(ph)PQGGGAPR ddPTM_A459_Selumetinib_30min_R2 1 PATPQGGGAPR 11 0 Q8IY33;Q8IY33-4;Q8IY33-2;Q8IY33-5 Q8IY33 MICALL2 MICAL-like protein 2 1 PAT(1)PQGGGAPR 97.957 0.04379 1793000.0 9156.6 8597.0 8021.7 9237.6 11201.0 7246.1 11232.0 11291.0 8336.4 9065.7 True False 8647.712828774036 9256.362256288086 7505.592555366591 7979.422944251164 9793.8302417895 8244.184501453361 11754.310255785771 11323.854940674322 10003.912938477586 8803.949685482632 0.982253776737704 1.0513874552862865 0.8525256076534625 0.9063458140167384 1.1124359624566167 0.9364188569873018 1.3351178363920193 1.2862244044110014 1.1362982860946658 1.0 13.103935184921985 -7.24870973670361 24.928091710840917 1.2132621674837991 0.9748544119812204 0.482340808161548 0.10842153838225915 581.9461407973578 1139609.930718973 0.04132243195499135 0.03178863008325879 5.640144923172709e-08 7.24870973670361 -0.23840775550257876 PAT(ph)STPDLASHR ddPTM_A459_Selumetinib_30min_R1 1 PATSTPDLASHR 12 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 PAT(0.487)S(0.289)T(0.224)PDLASHR 128.9 0.0032339 7784300.0 2865.1 2757.0 3345.6 3105.7 2490.7 2455.0 2185.2 2824.5 1229.0 2034.9 True False 2931.851255485872 2434.2091583054735 2891.2858960653425 2563.347796209287 2265.4166247687995 2430.3049289616533 2020.3686046853866 2749.5850847309825 2085.5232373914896 2296.0992366045184 1.2768835112812922 1.0601498051561538 1.259216435410252 1.116392425616576 0.9866370706689958 1.0584494303284553 0.8799134516821304 1.1975027215274376 0.9082896784877514 1.0 11.164969280797347 -6.069708307235669 4.1325933891979085 1.0122296122141823 1.185992897980491 0.4426739048537708 0.09767653656125012 0.21771346635727062 7.165572824118558 0.027371492900310428 0.037095981163255215 8.517098948835706e-07 6.069708307235669 0.17376328576630873 PAT(ph)STPDLASHR ddPTM_A459_Selumetinib_30min_R2 2 PATSTPDLASHR 12 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 PAT(0.685)S(0.185)T(0.13)PDLASHR;PAT(0.652)S(0.322)T(0.026)PDLASHR 124.51 0.0041122 39251000.0 127733.0 111509.0 106093.0 121217.0 117926.0 106877.0 111023.0 98797.0 84961.0 126336.0 True False 120634.11121571244 120061.38174205278 99267.0918853245 104707.03548901169 103111.08160818389 121598.33661719144 116185.78948790091 99084.48291327614 101955.57400868421 122688.35141965166 0.9832564364899423 0.978588271443852 0.809099565987194 0.8534390940739317 0.8404309000411593 0.9911155803314052 0.9469993535938148 0.8076111690046333 0.831012666067607 1.0 16.904638754025534 -5.178000496767282 10.338672124586827 0.8814044019560987 0.9814137972653096 0.24099375341601148 0.06788747431937393 0.810613535605741 96.78802615682959 0.017866949429820554 0.047409492743164104 6.637423111805362e-06 5.178000496767282 0.10000939530921094 PATS(ph)TPDLASHR ddPTM_A459_Selumetinib_30min_R1 2 PATSTPDLASHR 12 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 PAT(0.131)S(0.528)T(0.341)PDLASHR;PAT(0.034)S(0.893)T(0.073)PDLASHR 136.33 0.00093662 43528000.0 9463.400000000001 9665.400000000001 10517.8 11317.8 10156.2 8800.1 8516.5 7648.4 5202.4 7137.0 True False 9683.87880742907 8533.770474677443 9089.540530139897 9341.358691418181 9237.573503222746 8711.578983851505 7874.093548326513 7445.539586495466 8828.092831737584 8053.103470267071 1.202502717515427 1.0596871760290982 1.1287003282274297 1.1599700321630646 1.1470824306838805 1.0817666774077344 0.9777713123143789 0.9245553113759438 1.0962348694924704 1.0 12.97532915463716 -7.068904971578891 3.4346028288898576 0.9939982334575147 1.1349751469100609 0.6165003706604586 0.05178242377755005 0.16427571364847107 3.775795496382713 0.020367398010895127 0.01586838868746692 8.532868021526621e-08 7.068904971578891 0.14097691345254615 PAVEASTGGEATQETGKEEAGKEEPPPLT(ph)PPAR ddPTM_A459_Selumetinib_30min_R1 1 PAVEASTGGEATQETGKEEAGKEEPPPLTPPAR 33 2 Q9C0C2;E9PKK0;E9PKE7 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 PAVEAS(0.01)T(0.023)GGEAT(0.045)QET(0.122)GKEEAGKEEPPPLT(0.8)PPAR 47.085 0.020639 9198300.0 575.66 843.77 640.78 797.3 550.02 698.75 847.34 886.41 698.96 647.64 True False 589.0717579606289 744.9810161419692 553.7655955525911 658.0665221746027 500.2707881139181 691.721209414238 783.4244616026524 862.8995273345332 1186.0840699814128 730.7709025478159 0.8060963509998056 1.0194453741174014 0.7577827655998619 0.9005100228816841 0.684579512361173 0.9465637000632728 1.0720520738733044 1.1808071781813614 1.6230586984869786 1.0 9.513275380409938 -7.5435004711146885 1.8421184664825199 1.3167906685173927 0.8463357802058804 0.561641940874871 0.16683602625154995 0.2437246492817452 1.6238656666678952 0.10043602956982804 0.04932525917079872 2.8608792571961772e-08 7.5435004711146885 -0.4704548883115123 PAVVLPSAAPAGAAAPPSGS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 PAVVLPSAAPAGAAAPPSGSR 21 0 P19419 P19419 ELK1 ETS domain-containing protein Elk-1 1 PAVVLPSAAPAGAAAPPS(0.124)GS(0.876)R;PAVVLPSAAPAGAAAPPS(0.025)GS(0.975)R 207.38 1.245e-17 25073000.0 5665.1 7611.200000000001 4182.2 4681.6 4680.7 3997.5 6175.0 5393.3 2613.3 5697.8 True False 5797.085807634294 6720.077165649114 3614.280211180198 3864.0464445160205 4257.331511444707 3957.2887794395947 5709.214778478981 5250.2521640926225 4434.579232119758 6429.1681312719165 0.9016852086099396 1.0452483164909308 0.5621691854036435 0.6010181046162151 0.6621901036833604 0.6155211216504153 0.8880176504809335 0.816630092243977 0.6897594123491123 1.0 12.650416364279415 -9.43594343812686 12.001313538790038 0.9999961873412289 0.7511033027905175 0.19845063330727397 0.14849522663571 0.0 0.0 0.15551405829259 0.03771769932993004 3.664853020453047e-10 9.43594343812686 -0.24889288455071135 PAVVLPSAAPAGAAAPPSGS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 PAVVLPSAAPAGAAAPPSGSR 21 0 P19419 P19419 ELK1 ETS domain-containing protein Elk-1 1 PAVVLPS(0.004)AAPAGAAAPPS(0.323)GS(0.673)R;PAVVLPSAAPAGAAAPPS(0.224)GS(0.776)R;PAVVLPSAAPAGAAAPPS(0.171)GS(0.829)R 183.46 5.7839e-17 7888200.0 108144.0 72476.0 91162.0 95560.0 90267.0 79428.0 72964.0 80582.0 64217.3 83188.2 True False 102133.78941473244 78034.67615292962 85296.73616968094 82544.56314980511 78926.85246278123 90368.48602440457 76356.97057542314 80816.48027893173 77062.55438127925 80786.34051709904 1.2642457717603268 0.9659389898520405 1.0558311668001255 1.021763860343865 0.9769826428277905 1.1186109612834536 0.9451717962055926 1.0003730799246477 0.9539057455507391 1.0 16.30182375997517 -4.75579242654838 24.996962059153002 1.0073271266348862 1.2642461822672295 0.7134213878992913 0.049394442945864696 96.80053879780036 428455.9108898568 0.011914564912987768 0.10206595983934527 1.7547189790975094e-05 4.75579242654838 0.2569190556323433 PCESVS(ph)S(ph)SVQLPEDELFARS(ph)PDPR ddPTM_A459_Selumetinib_30min_R1 1 PCESVSSSVQLPEDELFARSPDPR 24 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 3 PCES(0.523)VS(0.588)S(0.588)S(0.302)VQLPEDELFARS(1)PDPR 61.525 0.022345 3342100.0 592.57 902.3 528.24 833.95 1124.2 605.42 1220.1 947.04 0.0 444.53 True False 606.375728059497 796.6582965321098 456.50790941462105 688.3162876803088 1022.5163084936304 599.330024477378 1128.0668746918548 921.9214227805372 0.0 501.5897555888779 1.208907720508761 1.5882666813974593 0.9101220755170135 1.37226942937104 2.0385510212288382 1.1948609751284707 2.2489830825342083 1.8379989074900072 0.0 1.0 8.970364072779011 -8.25427799078966 24.99917723257384 0.49999997150681974 1.5517644440137859 0.4692437618066272 0.446675750292223 435.4316767641241 1520030.4486200346 0.31720878169952316 0.11431562878572024 5.568292098778739e-09 8.25427799078966 1.0517644725069661 PCSEETPAIS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 PCSEETPAISPSK 13 0 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 PCSEET(0.001)PAIS(0.997)PS(0.002)K;PCSEETPAIS(0.998)PS(0.002)K 210.91 6.5172e-06 189109000.0 13206.199999999999 15572.8 12580.6 12869.7 8903.1 9911.7 11499.3 10859.900000000001 6143.2 12003.7 True False 13513.878765208028 13749.529336401698 10872.22362028923 10622.24848918912 8097.816176969968 9811.997297103548 10631.898542860456 10571.860174073287 10424.561718424251 13544.491820939447 0.9977398151118455 1.0151380737035307 0.8027044324749817 0.7842485808708887 0.5978678479801617 0.7244271270432194 0.7849610515784583 0.780528373735621 0.7696532181671178 1.0 13.725418645281039 -5.325902115309962 3.431541467589947 0.7605363567241338 1.0114222634256305 0.4773825051125501 0.09345495768182333 0.1801916370818332 4.166732922523338 0.024561541536295025 0.06123788313009888 4.72169450518419e-06 5.325902115309962 0.2508859067014967 PCSEETPAIS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 4 PCSEETPAISPSK 13 0 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 PCS(0.001)EET(0.246)PAIS(0.75)PS(0.004)K;PCSEETPAIS(0.997)PS(0.003)K;PCSEET(0.002)PAIS(0.997)PS(0.002)K;PCSEET(0.009)PAIS(0.99)PS(0.002)K 150.12 0.00050097 350837000.0 544093.0 417424.0 441376.0 460910.0 416047.0 354159.0 446417.0 466824.0 349561.0 438486.0 True False 513854.48923685076 449439.07857029117 412978.3486938526 398133.2628859022 363779.4563526283 402941.1875146931 467176.27505850367 468182.3805531265 419482.9675504 425825.7698565509 1.2067247348838337 1.05545298191252 0.9698293948554916 0.9349675173957237 0.8542917834098572 0.9462583432901044 1.0971066293519123 1.099469345668874 0.9851047006659845 1.0 18.699903734981525 -4.81874711525265 2.5831986516957666 0.9858901597248665 1.2425919646971058 0.4869962407838776 0.06884437803476308 0.4474630768609197 4.157634179317574 0.020853173928518858 0.24583703387707184 1.5179339859045467e-05 4.81874711525265 0.25670180497223927 PCSEETPAIS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 2 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 PCSEETPAIS(0.783)PS(0.217)KR;PCS(0.001)EET(0.008)PAIS(0.864)PS(0.127)KR 249.58 3.5695e-27 693634700.0 5249.0 6027.1 6968.299999999999 6704.6 4059.51 4996.9 4250.04 4735.1 2759.82 4886.9 True False 5371.291487223951 5321.444330077225 6022.043134132034 5533.767470929188 3692.328037264702 4946.6357228221905 3929.456061073167 4609.509766227536 4683.212970722359 5514.181217437037 0.9740868635653036 0.9650470523619469 1.092101056651716 1.0035519785657778 0.6696058565483411 0.8970752914648245 0.7126091628340713 0.8359373013805325 0.8493034207713421 1.0 12.42893096535834 -6.1546561479397095 9.288995058957475 0.8170815492976629 1.0125485895056032 0.4821637258322993 0.09165485984524523 0.2885650881474905 23.172283569287206 0.025535056167988117 0.033004812063482755 7.003963143540195e-07 6.1546561479397095 0.19546704020794037 PCSEETPAIS(ph)PSKR ddPTM_A459_Selumetinib_30min_R2 3 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 PCSEET(0.001)PAIS(0.84)PS(0.159)KR;PCSEETPAIS(0.941)PS(0.059)KR;PCSEETPAIS(1)PSKR 141.59 0.00099321 288911800.0 177728.0 154968.0 143222.0 157235.0 145700.0 99669.0 140383.0 131805.0 106476.0 148521.0 True False 167850.58926155468 166853.54729934278 134007.2524483232 135819.32175449625 127395.86342547346 113397.50004490066 146911.08766363718 132188.53072850767 127774.17518801139 144232.81282609934 1.163747596491314 1.1568348701658973 0.9291037859040784 0.9416672884155204 0.8832654714920793 0.7862115272037533 1.0185691091025662 0.9164941606448916 0.8858883958816498 1.0 17.1380398880884 -5.268665690843747 4.732162446907716 0.914168554776506 1.1646131424957844 0.7126697214108698 0.060972342457208555 0.09067045463235902 5.8893194872109556 0.016110877564934026 0.03952005285070942 5.386842888065259e-06 5.268665690843747 0.25044458771927836 PCSEETPAISPS(ph)KR ddPTM_A459_Selumetinib_30min_R1 5 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 PCSEETPAIS(0.003)PS(0.997)KR;PCSEETPAIS(0.033)PS(0.967)KR;PCSEETPAIS(0.08)PS(0.92)KR;PCSEETPAIS(0.001)PS(0.999)KR;PCSEETPAIS(0.004)PS(0.996)KR 139.49 0.00029272 3551976000.0 16672.6 21122.3 22253.0 22760.0 14686.8 15490.2 15891.399999999998 15529.0 9220.9 17299.3 True False 17061.039140767778 18649.291296509127 19231.16482697933 18785.393258113578 13358.381533165148 15334.382651976293 14692.69890376045 15117.120474699032 15647.193832109999 19519.833664451606 0.8740360924201089 0.9554021625948658 0.9852115114076007 0.9623746585671195 0.684349147784628 0.7855795759111609 0.7527061529483187 0.7744492465747522 0.8016048753840441 1.0 14.25265313877744 -6.240613275040839 24.8094146577532 0.7854400971607973 0.9479776593632478 0.4295103822424162 0.0805140245807341 610.9513223986581 727804.9371383274 0.022434763492518904 0.028930111614433065 5.746279217285983e-07 6.240613275040839 0.16253756220245053 PCSEETPAISPS(ph)KR ddPTM_A459_Selumetinib_30min_R2 5 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 PCSEETPAIS(0.003)PS(0.997)KR;PCSEETPAIS(0.009)PS(0.991)KR;PCSEETPAIS(0.003)PS(0.997)KR;PCSEETPAIS(0.007)PS(0.993)KR;PCSEETPAIS(0.032)PS(0.968)KR 105.89 0.0029255 4071289100.0 338108.0 329463.0 301282.0 321522.0 304813.0 211425.0 289056.0 272673.0 210787.0 287517.0 True False 319317.3109135633 354731.7527094858 281897.84413103934 277730.1489436137 266519.66587720567 240546.87462494007 302497.6767535977 273466.4332865549 252950.2898808693 279215.6371511202 1.1436225928160995 1.2704580457200325 1.0096062205085865 0.9946797814668865 0.9545298701625259 0.8615093233290105 1.0833837239204356 0.9794094488287787 0.9059316751087431 1.0 18.09102021472596 -5.370203369210702 4.751759537922437 0.9698142305811047 1.2056590655696184 0.6923792373395898 0.06256385289538964 0.11426506710223597 4.001622631711412 0.016554299284241857 0.03607095826300709 4.263798090777415e-06 5.370203369210702 0.23584483498851372 PDPAGHLT(ph)LRDNRLK ddPTM_A459_Selumetinib_30min_R1 2 PDPAGHLTLRDNRLK 15 2 Q9NTJ4-3;Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4 Q9NTJ4-3 MAN2C1 Alpha-mannosidase 2C1 1 PDPAGHLT(1)LRDNRLK;PDPAGHLT(1)LRDNRLK 102.62 0.0079904 28416000.0 22874.0 27772.0 28654.0 29652.0 27769.0 24062.0 23471.0 23012.0 13647.900000000001 20110.3 True False 23406.919694943943 24520.441329147467 24762.944185155513 24473.834836976454 25257.298853015145 23819.958126547983 21700.5635733895 22401.64700648941 23159.489496822884 22691.652895910287 1.0315211413780514 1.0805930022650214 1.091279877175388 1.0785390975810039 1.1130656267691836 1.0497233602070941 0.9563236170116364 0.9872197106684483 1.0206171230918535 1.0 14.469874080577366 -7.061190438112311 5.38459519612454 0.9907037424246168 1.0800277379459633 0.7489580980907323 0.02404108606109983 0.10643248966561279 6.298997373218182 0.009379450308761755 0.0073367815085681985 8.685794737046905e-08 7.061190438112311 0.08932399552134651 PDSVDIEHMSSGLT(ph)DLLK ddPTM_A459_Selumetinib_30min_R2 1 PDSVDIEHMSSGLTDLLK 18 0 Q8WU76 Q8WU76 SCFD2 Sec1 family domain-containing protein 2 1 PDSVDIEHMS(0.012)S(0.206)GLT(0.783)DLLK 69.485 0.034605000000000004 23812000.0 113750.0 112710.0 115680.0 119400.0 110090.0 94078.0 107980.0 103590.0 87098.0 99031.0 True False 107428.2303773286 121354.49458022899 108237.27474286061 103137.51402351166 96259.50998291267 107036.3905449453 113001.28395831073 103891.42974975237 104520.03372145294 96171.71771656134 1.1170459770089853 1.2618522104168575 1.1254584748279015 1.0724308192922165 1.0009128699001724 1.1129716000332288 1.1749949636061376 1.0802700858057113 1.0868063522531217 1.0 16.55332506658919 -1.5228787452803376 0.10304841337695958 0.9781966391305952 1.5477096582136316 0.29239676188216024 0.06179283054058906 178.1423770578856 1.3000865499904366 0.7857852882775853 14.359588706907585 0.029999999999999995 1.5228787452803376 0.5695130190830364 PETVGS(ph)ADSITGNFGTER ddPTM_A459_Selumetinib_30min_R1 1 PETVGSADSITGNFGTER 18 0 A0A0C4DGB3;Q86UD5-2 A0A0C4DGB3 SLC9B2 1 PET(0.001)VGS(0.998)ADSIT(0.001)GNFGTER 73.296 0.018136000000000003 14818000.0 295.22 350.0 410.61 468.96 286.97 389.33 357.72 177.08 248.9 181.33 True False 302.09805160187767 309.0218372894144 354.8514173192821 387.0649394694618 261.0136141686684 385.4136936833564 330.7368923979756 172.3832631630952 422.36512106325614 204.60547180377293 1.4764905793507082 1.5103302691033702 1.7343202710609944 1.8917624052629287 1.2756922474634196 1.8836920160815045 1.61646161992759 0.8425154109681853 2.0642904480498245 1.0 7.67670091764687 -7.571553323242177 24.999725366195833 1.3179389845845058 1.6345489455348785 0.15620896647110938 0.3451853831601559 212.14678861815588 108958.2068582682 0.15169122172169863 0.08757896453181004 2.6819252971110103e-08 7.571553323242177 0.31660996095037275 PETVGS(ph)ADSITGNFGTER ddPTM_A459_Selumetinib_30min_R2 1 PETVGSADSITGNFGTER 18 0 A0A0C4DGB3;Q86UD5-2 A0A0C4DGB3 SLC9B2 1 PET(0.001)VGS(0.995)ADS(0.003)ITGNFGTER 68.257 0.027907 7170800.0 3407.5 3919.1 3284.2 3120.0 1433.6 2936.9 3190.5 2953.0 2795.2 3055.7 True False 3218.12479130327 4219.682368107323 3072.8981475665937 2695.050617699796 1253.4983514533901 3341.4313164762243 3338.864571855813 2961.5927411045345 3354.318104413478 2967.4740013379305 1.0844660441346174 1.421977872832185 1.0355265610351199 0.9081968760247576 0.42241258083077776 1.1260187334310896 1.1251537740011996 0.9980180920773882 1.1303614127372752 1.0 11.53501967483082 -5.45804726525026 6.258766857275535 0.9514147210229287 1.2514124581904114 0.23591339526784894 0.20881824800122897 0.32915127351490275 24.870719302874548 0.058172250596193575 0.12139765761779547 3.4829940676140164e-06 5.45804726525026 0.2999977371674827 PFERLPADVS(ph)PINYSLCLK ddPTM_A459_Selumetinib_30min_R1 1 PFERLPADVSPINYSLCLK 19 1 E9PJY4;E9PPD4;E9PP11;E9PLK3;P55786-2;P55786;E9PJF9;E9PPZ2 E9PJY4 NPEPPS Puromycin-sensitive aminopeptidase 1 PFERLPADVS(0.971)PINY(0.009)S(0.02)LCLK 64.377 0.014128 17953000.0 1347.1 2234.7 4926.6 5518.3 2803.6 3465.2 2456.2 1982.1 1584.6 1343.2 True False 1378.4848089996933 1973.0602851161552 4257.59477987671 4554.632496320219 2550.0148750157828 3430.3432341498647 2270.9268565020343 1929.52826923182 2688.95046539508 1515.61280387596 0.9095230691337645 1.30182344730154 2.8091573052091725 3.0051425302507386 1.6824975801830715 2.2633374601859124 1.4983555501078296 1.2731010613643083 1.7741671609783705 1.0 10.565685517540537 -7.374820341597541 5.479478597254492 1.3931503711316136 2.031005474025357 0.1882625985170947 0.619398977480558 0.44379430069067044 18.49102139251709 0.289049406196511 0.19210874548481094 4.2187098640239744e-08 7.374820341597541 0.6378551028937436 PFGSGRAGS(ph)TGMGRPPRSQR ddPTM_A459_Selumetinib_30min_R2 1 PFGSGRAGSTGMGRPPRSQR 20 3 Q96JB3-2;Q96JB3 Q96JB3-2 HIC2 Hypermethylated in cancer 2 protein 1 PFGSGRAGS(0.978)T(0.006)GMGRPPRS(0.016)QR 55.851000000000006 0.04753 0.0 20665.0 18121.0 19362.0 18577.0 20055.0 21082.0 18110.0 19958.0 20454.0 26679.0 True False 19516.52202854939 19510.82243180137 18116.269999751657 16046.78055288754 17535.511606025204 23985.854136658305 18952.150884284205 20016.07447577523 24545.3715325105 25908.70794963335 0.7532804054331694 0.7530604177456669 0.6992347914442423 0.6193585795201582 0.6768192238730824 0.9257834926885169 0.7314973375410027 0.7725616620746419 0.94737922015358 1.0 14.661149450600654 -8.246630421155396 0.6560273417077884 1.008355683304912 0.7114120874327545 0.6009374212251235 0.07577076859649859 0.5240764282644415 0.5173272582597321 0.07889210718556035 0.03493213949381328 5.667213562512231e-09 8.246630421155396 -0.2969435958721576 PFS(ph)GTTPSR ddPTM_A459_Selumetinib_30min_R1 3 PFSGTTPSR 9 0 A0A1B0GTR0 A0A1B0GTR0 1 PFS(0.333)GT(0.333)T(0.333)PSR;PFS(0.333)GT(0.333)T(0.333)PSR;PFS(0.333)GT(0.333)T(0.333)PSR 87.75399999999998 0.032101 231595000.0 12028.8 15398.7 15597.0 16717.800000000003 15014.800000000001 13218.599999999999 15107.6 12747.800000000001 7089.700000000001 11318.400000000001 True False 12309.047636029625 13595.813045338584 13479.01306818841 13798.350061972376 13656.713991078246 13085.632885528517 13968.021568801452 12409.686933309831 12030.703088799379 12771.226890552163 0.9638108962840174 1.0645659310458597 1.055420374542077 1.0804247845741473 1.069334536776662 1.0246183078314068 1.093710235399126 0.9716910551867346 0.9420162363335189 1.0 13.640609506304425 -7.810638087503068 10.995161443304076 0.967447919191107 1.051908364312327 0.49599921558035276 0.03642329353408712 0.4660617455273374 101.73294335508345 0.019349534256295584 0.009303857782974989 1.546542689793662e-08 7.810638087503068 0.08446044512122008 PFSAPKPQTS(ph)PSPK ddPTM_A459_Selumetinib_30min_R1 2 PFSAPKPQTSPSPK 14 1 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 PFSAPKPQT(0.072)S(0.839)PS(0.089)PK;PFSAPKPQT(0.089)S(0.7)PS(0.211)PK 178.67 0.00034067 23486400.0 3953.1000000000004 5267.5 3056.0 4119.5 2896.7 3246.3 3663.0 3293.2 2031.16 4157.6 True False 4045.1995386064027 4650.778651205687 2641.0119854064083 3400.10665759222 2634.693996453923 3213.645169404568 3386.6969609017815 3205.853638178817 3446.7301699431227 4691.268458453465 0.8622826799257514 0.991369113150023 0.5629633027390316 0.7247734142064228 0.5616165478030397 0.6850269171046302 0.7219149769182572 0.6833660590030839 0.73471177368506 1.0 12.19576234627141 -10.442753522199657 15.235981465815444 0.9999999997885454 0.7210324873205316 0.31637580337559257 0.12097515206374206 0.0 0.0 0.12369394424589772 0.030000188080888134 3.607833425033067e-11 10.442753522199657 -0.27896751246801377 PFSAPKPQTS(ph)PSPK ddPTM_A459_Selumetinib_30min_R2 1 PFSAPKPQTSPSPK 14 1 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 PFSAPKPQT(0.177)S(0.515)PS(0.308)PK 90.872 0.009732 38722000.0 53587.0 38701.0 42652.0 50112.0 35545.0 33417.0 50981.0 41560.0 28622.0 37313.0 True False 50608.84906575738 41669.24225667157 39907.81675598634 43286.659151978274 31079.519323668203 38019.888420676885 53351.71751693504 41680.9327193716 34347.199765498925 36235.67673918323 1.396658034843097 1.149950711741856 1.1013404563473286 1.1945867456414994 0.8577049504931848 1.0492390881598828 1.4723532804685686 1.150273334740846 0.9478834909783204 1.0 15.145123217963357 -4.75084224548224 3.2765707226535605 1.1090942491073426 1.4485270957913365 0.24348882231427316 0.1567547494270851 0.6074255154063882 9.555015196937942 0.041759436588657814 0.5504236413252528 1.7748340602187307e-05 4.75084224548224 0.339432846683994 PFSAPKPQTSPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 PFSAPKPQTSPSPK 14 1 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 PFSAPKPQT(0.1)S(0.363)PS(0.537)PK 66.809 0.037441 24315000.0 4820.6 7586.7 4204.1 4990.8 4163.8 5054.0 5609.4 5405.0 2939.4 6451.7 True False 4932.910600745247 6698.445637038855 3633.2063114682874 4119.250468918862 3787.1850251785977 5003.161348664847 5186.2784418461515 5261.641842085665 4987.947114718102 7279.83853987979 0.6776126384839716 0.9201365662636612 0.4990778698682899 0.5658436579813049 0.5202292611892371 0.6872626805192115 0.7124166852650816 0.7227690302829916 0.6851727668675007 1.0 12.829690737792394 -9.441151145275338 0.6509375272410999 1.014567072783403 0.6497916588031765 0.4478897487671306 0.11285721126321269 3.929958590793158 1.9987136464783664 0.27071288156421014 0.04684183527310419 3.621169507837873e-10 9.441151145275338 -0.3647754139802266 PGAY(ph)T(ph)T(ph)QLFGT(ph)IITARTGCQLLW ddPTM_A459_Selumetinib_30min_R1 1 PGAYTTQLFGTIITARTGCQLLW 23 1 E9PKI7 E9PKI7 DIS3L 4 PGAY(0.998)T(0.994)T(0.994)QLFGT(0.951)IIT(0.046)ART(0.017)GCQLLW 41.71100000000001 0.046124 0.0 463.81 518.56 675.42 539.81 357.42 442.18 438.79 492.59 132.35 246.57 True False 474.6158705828426 457.8467541279964 583.7016738164909 445.54231698867716 325.09142410762615 437.7320706673169 405.69171702814435 479.52491304217875 224.58828353845695 278.2196612951872 1.7059034159317796 1.6456304777189248 2.0979885860661427 1.601404857279166 1.1684703467549284 1.5733326272829051 1.45817055178466 1.7235479002808842 0.8072336889957316 1.0 8.120080565984061 -7.631890441517879 0.3237500156159729 0.918819067980552 1.8622789171894605 0.4753774588589901 0.26351782090103626 1.4014682985107294 0.4566724423282419 0.4119947684011908 0.4652001528218942 2.3340467926998756e-08 7.631890441517879 0.9434598492089085 PGGQAPSS(ph)PSYENSLHSLQSR ddPTM_A459_Selumetinib_30min_R2 3 PGGQAPSSPSYENSLHSLQSR 21 0 Q99081;Q99081-4;Q99081-2;B4DZP2 Q99081 TCF12 Transcription factor 12 1 PGGQAPS(0.06)S(0.706)PS(0.221)Y(0.013)ENSLHSLQSR;PGGQAPS(0.027)S(0.575)PS(0.397)Y(0.002)ENSLHSLQSR;PGGQAPS(0.231)S(0.66)PS(0.108)YENSLHSLQSR 125.99 4.4382e-05 38409600.0 108893.0 61800.0 118166.0 146304.0 153236.0 103354.0 127395.0 154202.0 144724.0 138136.0 True False 102841.16299321695 66539.86128168013 110563.32820941306 126377.14281152302 133985.12373277874 117590.07534580115 133319.11992840344 154650.70229048483 173672.8439264222 134147.65475956956 0.7666266188368133 0.49601956441906 0.8241912868888668 0.942074932566108 0.9987884169344434 0.8765719800063276 0.9938237099064379 1.152839403474198 1.294639434716119 1.0 17.03346230729604 -5.883684829680537 0.5346145665227173 1.137907900715539 0.5367704601637986 0.6557775463424154 0.12100102763690147 0.948977774219511 0.45358015173004135 0.09112193848378738 0.31481082603857896 1.3071191288390925e-06 5.883684829680537 -0.6011374405517405 PGHLQEGFGCVVTNR ddPTM_A459_Selumetinib_30min_R2 1 PGHLQEGFGCVVTNR 15 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 134.37 0.00064154 3796900.0 15986.0 18116.0 18142.0 16288.0 16012.0 13269.0 16927.0 11881.0 12402.0 15101.0 False True 15097.56211702834 19505.438947878913 16974.763471516086 14069.546301632783 14000.4294109038 15096.684306010773 17714.13904021418 11915.571742994562 14882.746540832846 14664.994892890041 1.0294965819829927 1.3300678991259411 1.1575021740884395 0.9593966042534425 0.9546835517611779 1.0294367244089546 1.20791989152362 0.8125179606282393 1.0148483957569174 1.0 13.84008894822335 -5.680310320438302 5.522610259342837 0.9977780600345696 1.1935718406656837 0.3317951574832766 0.11362168054457435 0.2194186440930187 11.135273919331237 0.0308098658975247 0.053802809648935475 2.0878037800712735e-06 5.680310320438302 0.19579378063111408 PGPNIES(ph)GNEDDDASFK ddPTM_A459_Selumetinib_30min_R2 1 PGPNIESGNEDDDASFK 17 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 PGPNIES(1)GNEDDDASFK 110.77 0.0020968 3875600.0 23486.0 19156.0 19723.0 20476.0 20136.0 15289.0 23276.0 23502.0 17066.0 16845.0 True False 22180.74214190715 20625.203603751834 18454.043652778735 17687.133476929823 17606.335661876026 17394.92097027649 24358.380120519007 23570.38692903446 20479.6768638811 16358.64108143385 1.3559037105521596 1.2608139943335694 1.1280914814937195 1.0812104372779312 1.076271285263312 1.0633475533624097 1.4890222237447592 1.4408523795894965 1.2519179779012573 1.0 13.997765287578252 -7.2482431516009544 24.991295498857625 1.332185853709528 1.1565137564210848 0.14394558634523913 0.15014278760909652 1171.5898212185793 2218784.471131816 0.05838231144582339 0.04495683354670825 5.6462076797823004e-08 7.2482431516009544 -0.17567209728844313 PGPS(ph)PLPHR ddPTM_A459_Selumetinib_30min_R2 1 PGPSPLPHR 9 0 P08621;P08621-4 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 PGPS(1)PLPHR 79.65899999999998 0.032004000000000005 6153100.0 37475.0 30272.0 27258.0 32338.0 30229.0 25559.0 35161.0 36617.0 25999.0 33643.0 True False 35392.2895243111 32593.765060178303 25504.24995626643 27933.50861383847 26431.362769311178 29079.52024849871 36796.05617019976 36723.549407729304 31199.52647275545 32671.639174988395 1.083272539059059 0.9976164613476232 0.7806235193669462 0.8549772622128743 0.809000204359063 0.890053911673963 1.1262384471474205 1.124019190192417 0.9549421841264728 1.0 14.995751217866985 -7.2479180971037325 24.078927717644007 1.0616348853693442 0.894947672556315 0.3641081763916426 0.09556846635191374 513.4261127731559 914318.9131912051 0.03936600629455121 0.030298654488870563 5.650435254125017e-08 7.2479180971037325 -0.16668721281302923 PGPTPSGTNVGSS(ph)GRSPSK ddPTM_A459_Selumetinib_30min_R2 1 PGPTPSGTNVGSSGRSPSK 19 1 P60468 P60468 SEC61B Protein transport protein Sec61 subunit beta 1 PGPTPSGTNVGS(0.014)S(0.483)GRS(0.483)PS(0.019)K 74.51899999999998 0.0054084 113820000.0 13337.0 3777.4 8167.1 8674.9 3855.4 3624.6 11009.0 8669.8 5321.5 6215.8 True False 12595.78293224114 4067.114433744636 7641.637677666138 7493.3636549628045 3371.0501842866893 4123.855749157182 11520.94031391965 8695.027682637348 6385.948695133201 6036.333703412081 2.086661134244663 0.6737722984807267 1.2659402301345015 1.2413766407127436 0.5584598781179342 0.6831722618029124 1.90859897414342 1.4404484758227367 1.0579184334231717 1.0 12.559456848470704 -4.744540028473613 24.897469810263274 1.1120955930904808 2.08666415764371 0.37449152564019783 0.38480267828552583 1183.0868029830453 1742919.7398678628 0.10179987660508455 2.852096135129599 1.800777151023628e-05 4.744540028473613 0.9745685645532292 PGPTPSGTNVGSSGRS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 6 PGPTPSGTNVGSSGRSPSK 19 1 P60468 P60468 SEC61B Protein transport protein Sec61 subunit beta 1 PGPTPSGTNVGSS(0.004)GRS(0.996)PSK;PGPTPSGTNVGSS(0.025)GRS(0.961)PS(0.014)K;PGPTPSGTNVGS(0.022)S(0.336)GRS(0.634)PS(0.009)K;PGPTPSGTNVGSSGRS(0.999)PSK;PGPTPS(0.004)GT(0.001)NVGS(0.025)S(0.243)GRS(0.701)PS(0.027)K;PGPTPSGTNVGSS(0.027)GRS(0.973)PSK 179.84 2.5709e-12 457165000.0 13630.900000000001 16243.2 21684.800000000003 19067.0 13987.0 17142.100000000002 15025.899999999998 17715.5 9201.53 15379.9 True False 13948.473448885692 14341.438592741193 18740.123266080136 15737.306381917908 12721.878319605421 16969.666037781488 13892.484265578501 17245.627391946084 15614.324356838828 17354.05997791235 0.8037585133760531 0.8264025024112214 1.0798696840930548 0.9068371552217641 0.7330779273436526 0.9778499128953048 0.8005322260762252 0.9937517453492568 0.8997505123707191 1.0 14.082985599977697 -8.437762250678347 0.9858765507407303 0.994409221228047 0.8831046356642653 0.11176089492296937 0.09868375563847669 1.3149187642993063 2.8089180986962843 0.0946697649843224 0.03206805634340176 3.649536817790611e-09 8.437762250678347 -0.11130458556378164 PGPTPSGTNVGSSGRS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 PGPTPSGTNVGSSGRSPSK 19 1 P60468 P60468 SEC61B Protein transport protein Sec61 subunit beta 1 PGPTPSGTNVGS(0.003)S(0.022)GRS(0.971)PS(0.005)K;PGPTPSGTNVGSS(0.001)GRS(0.992)PS(0.007)K 139.55 7.1954e-05 225940000.0 112379.0 41840.0 76869.0 84737.0 32793.0 29447.0 88982.0 61690.0 46545.0 56618.0 True False 106133.42506878077 45048.99346319572 71923.3322286392 73195.67442052175 28673.250166860355 33503.05695674874 93119.83931448791 61869.50768667072 55855.300575960704 54983.291228769456 1.9302850501835276 0.8193215148900415 1.30809434323215 1.3312348676250731 0.5214902477838097 0.6093316025290716 1.6936024969302654 1.1252419835918828 1.0158595334637768 1.0 15.746705646846106 -4.751629517741047 24.88501221437014 1.0581726684883312 1.9302869120101775 0.3898318896152556 0.33121052222542613 429.3425496923388 1089047.9065920128 0.08612930844106663 1.1102133973122634 1.771619623984236e-05 4.751629517741047 0.8721142435218463 PGRPLS(ph)PANVPALPGETVTSPVR ddPTM_A459_Selumetinib_30min_R2 1 PGRPLSPANVPALPGETVTSPVR 23 1 Q8IY33;Q8IY33-5;Q8IY33-3 Q8IY33 MICALL2 MICAL-like protein 2 1 PGRPLS(1)PANVPALPGETVTSPVR 94.031 5.0519e-05 3505600.0 5587.2 6868.9 6517.0 6721.5 7756.3 6290.6 8164.3 7033.4 5350.0 5927.7 True False 5276.685791333712 7395.72254300538 6097.7033151731 5806.0201047657665 6781.884251798217 7157.073049618758 8543.956127253537 7053.866029557949 6420.149491489739 5756.551898985783 0.9166400101879363 1.2847486955356722 1.0592631530426093 1.0085933744102435 1.1781157141991687 1.2432916744622289 1.4842142096832052 1.225363056450639 1.115276923434126 1.0 12.490989199144828 -6.502385290764451 4.464302445551225 1.2426633924253758 1.0822816143795213 0.1712671395891786 0.14434029616987587 0.3327068302296531 16.26238253540928 0.04723020575439986 0.050944462540157213 3.1449569810592843e-07 6.502385290764451 -0.16038177804585452 PGS(ph)LPLNAEACWPK ddPTM_A459_Selumetinib_30min_R1 2 PGSLPLNAEACWPK 14 0 Q01581;D6RIW1 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 PGS(1)LPLNAEACWPK;PGS(1)LPLNAEACWPK 175.27 7.049899999999999e-05 70740000.0 4589.1 5628.4 5839.200000000001 6442.1 3296.3 4558.1 4172.3 3936.5 3244.5 3682.6 True False 4696.017101165831 4969.42431142783 5046.268712429684 5317.108168193914 2998.1502470090336 4512.24965242367 3857.580051862 3832.091232445923 5505.679531095758 4155.297581561654 1.130127748732971 1.1959250123213099 1.2144181285166062 1.2795974449068521 0.7215247977215297 1.0859028899508723 0.9283522963503941 0.9222182424310842 1.3249783975824423 1.0 12.020736083936898 -6.201036844095275 24.999782331508214 0.9942678832436891 1.2050392316778227 0.327238426809196 0.1459678283852321 289.5310652775796 119832.45829787337 0.04195601067930482 0.05416496593118325 6.294527799176294e-07 6.201036844095275 0.2107713484341336 PGS(ph)LPLNAEACWPK ddPTM_A459_Selumetinib_30min_R2 2 PGSLPLNAEACWPK 14 0 Q01581;D6RIW1 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 PGS(1)LPLNAEACWPK;PGS(1)LPLNAEACWPK 98.694 0.010215 16151000.0 45334.0 48053.0 43162.0 40572.0 39299.0 31227.0 41518.0 39215.0 28561.0 40046.0 True False 42814.51776638073 51738.51058525204 40385.00391123239 35046.0236093962 34361.90828248242 35528.23579951754 43448.66926635624 39329.10915760725 34273.99806101653 38889.76792799644 1.1009198575227006 1.3303887716955465 1.0384480562086238 0.9011630944746996 0.8835719551246165 0.9135625562306593 1.1172262417919414 1.0112970905463936 0.8813114576686106 1.0 15.247103005164265 -5.457822164009563 5.601820384295071 0.9607961908905964 1.2128896450877062 0.5852741951383575 0.08553407730391305 0.14758412333459978 9.030672760142465 0.023242839190702535 0.0486622427845992 3.484799822786932e-06 5.457822164009563 0.2520934541971098 PGSGSSSGSSNSGSQPGSHPGSQSGS(ph)GER ddPTM_A459_Selumetinib_30min_R2 1 PGSGSSSGSSNSGSQPGSHPGSQSGSGER 29 0 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819;O95819-6;E7EN19 G5E948;O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 PGSGSSSGSSNSGSQPGS(0.001)HPGS(0.131)QS(0.261)GS(0.606)GER 93.34 4.6188e-07 617060.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PGSVFS(ph)VEGENLDLAMSK ddPTM_A459_Selumetinib_30min_R1 1 PGSVFSVEGENLDLAMSK 18 0 O43157-2;O43157 O43157-2 PLXNB1 Plexin-B1 1 PGS(0.118)VFS(0.882)VEGENLDLAMSK 79.02199999999998 0.037743 0.0 321.45 352.12 340.6 365.95 394.47 406.78 492.18 421.33 239.3 377.55 True False 328.9391595671821 310.89362670385293 294.3483907818795 302.04370223227875 358.7902581493351 402.68816252668887 455.05446634360874 410.1549597272809 406.0746222195145 426.01222014842784 0.7721355022458645 0.7297763115704375 0.6909388436775944 0.7090024368949863 0.842206493570368 0.9452502615685235 1.068172331265667 0.9627774517462855 0.9531994694378324 1.0 8.734751004485641 -6.610982784438699 2.259940896216827 0.9936638862965816 0.7235613714224602 0.9203223525216331 0.03629037924073221 0.0807801791539432 0.8397038475425469 0.014147537935327683 0.014371094553394175 2.449160325357881e-07 6.610982784438699 -0.2701025148741214 PGTAY(ph)Y(ph)SFS(ph)AT(ph)SS(ph)RR ddPTM_A459_Selumetinib_30min_R2 1 PGTAYYSFSATSSRR 15 1 Q99081;Q99081-3;B4DGI9 Q99081 TCF12 Transcription factor 12 5 PGT(0.484)AY(0.755)Y(0.755)S(0.622)FS(0.651)AT(0.677)S(0.067)S(0.99)RR 42.958 0.047474 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PGWLS(ph)SPTLGR ddPTM_A459_Selumetinib_30min_R2 1 PGWLSSPTLGR 11 0 C9JS59;C9J266;Q5XPI4;Q5XPI4-2 C9JS59 RNF123 E3 ubiquitin-protein ligase RNF123 1 PGWLS(0.549)S(0.388)PT(0.063)LGR 97.734 0.018946 27712000.0 77184.0 51123.0 65910.0 69253.0 68581.0 44608.0 58630.0 52778.0 40993.0 50827.0 True False 72894.4222720328 55043.96971364618 61669.4223573821 59820.621931911555 59965.24165808106 50752.347088893526 61356.41117314096 52931.57524213172 49192.7454401194 49359.49244559444 1.4768065606099836 1.1151648241585415 1.2493933649207605 1.211937541656201 1.2148674689914327 1.0282185771021517 1.2430519061914969 1.0723687100404151 0.9966217844387513 1.0 15.591039939150463 -1.522878745282009 0.17304723699750454 0.9752409398600139 2.5133227330658685 0.5654249421971282 0.09329910555648956 46.828207188036686 0.5133124607727184 0.2268600947731262 18.73127027044818 0.029999999999884546 1.522878745282009 1.5380817932058546 PGWLSS(ph)PTLGR ddPTM_A459_Selumetinib_30min_R1 2 PGWLSSPTLGR 11 0 C9JS59;C9J266;Q5XPI4;Q5XPI4-2 C9JS59 RNF123 E3 ubiquitin-protein ligase RNF123 1 PGWLS(0.293)S(0.628)PT(0.079)LGR;PGWLS(0.271)S(0.655)PT(0.073)LGR 114.76 0.0063725000000000006 79690000.0 6540.2 8654.5 6319.2 6675.4 6435.0 5791.9 7190.1 7385.9 3658.7 7359.9 True False 6692.573934986111 7641.227116632106 5461.08734888095 5509.666702777305 5852.955386191527 5733.63874462444 6647.744968217279 7190.0019392156355 6208.546679124687 8304.614856496926 0.80588613086016 0.9201181811163905 0.6575967029474694 0.6634463846889832 0.7047834833198316 0.6904159727695087 0.8004880518952143 0.8657839121329872 0.7476020003826634 1.0 13.019697546467283 -9.240878749878068 0.6449754880965104 1.0065604270893713 0.7470164699438898 0.43308154082626127 0.08229693022210968 2.723826967883999 1.6129213983081834 0.14155233143527135 0.03545858817333032 5.742767714266502e-10 9.240878749878068 -0.2595439571454815 PGWLSS(ph)PTLGR ddPTM_A459_Selumetinib_30min_R2 2 PGWLSSPTLGR 11 0 C9JS59;C9J266;Q5XPI4;Q5XPI4-2 C9JS59 RNF123 E3 ubiquitin-protein ligase RNF123 1 PGWLS(0.327)S(0.668)PT(0.005)LGR;PGWLS(0.004)S(0.989)PT(0.007)LGR 126.71 0.0031068000000000003 26401900.0 129766.0 90636.0 104042.0 116768.0 116123.0 88579.0 112074.0 105822.0 80625.0 101277.0 True False 122554.12521445644 97587.48975932636 97348.05099236451 100863.99696396486 101534.59058720835 100779.95320989745 117285.66307041798 106129.92450022491 96752.2528507217 98352.86986075251 1.246065573764832 0.9922180196418287 0.989783532805798 1.0255318132228128 1.0323500547666835 1.0246773007496495 1.19249863513358 1.0790729813017466 0.9837257721884786 1.0 16.58567952939407 PHS(ph)S(ph)T(ph)S(ph)SPSVPK ddPTM_A459_Selumetinib_30min_R2 1 PHSSTSSPSVPK 12 0 Q68D10-2;Q68D10 Q68D10-2 SPTY2D1 Protein SPT2 homolog 4 PHS(0.995)S(0.996)T(0.98)S(0.589)S(0.439)PS(0.001)VPK 85.522 0.014434 0.0 1039.2 0.0 910.28 0.0 711.38 0.0 0.0 0.0 0.0 886.45 True False 981.4454242472069 0.0 851.7135758379268 0.0 622.01008458211 0.0 0.0 0.0 0.0 860.8558852263012 1.1400809834612506 0.0 0.9893799768982574 0.0 0.7225484488830514 0.0 0.0 0.0 0.0 1.0 9.749627927894355 -11.4623896640824 4.9834558555715 1.3486675659675582 0.30199872510320536 0.1804019155603449 0.4357701581165154 0.1442258398754911 0.0017506094875678572 0.03604832467317453 0.09885264904618912 3.4483420327789198e-12 11.4623896640824 -1.0466688408643527 PHVMS(ph)PTNR ddPTM_A459_Selumetinib_30min_R2 1 PHVMSPTNR 9 0 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 PHVMS(0.5)PT(0.5)NR 88.134 0.031598 4452800.0 31086.0 24857.0 28184.0 21374.0 29437.0 19199.0 28323.0 26300.0 19482.0 29846.0 True False 29358.36456711766 26763.451972147624 26370.672124418994 18462.8243277934 25738.860889881038 21843.48797883041 29640.07562095979 26376.528645800623 23378.94437256133 28984.26843077914 1.0129068683321074 0.9233785574427964 0.9098270735174154 0.6369946639117948 0.8880286542802054 0.753632544875076 1.0226263150904382 0.910029132140893 0.8066080545864194 1.0 14.822982451685712 -9.379797546349346 12.546617988794722 0.9999999191494339 0.8716650745233986 0.1050216972843302 0.11038252856735765 0.0 0.0 0.10913068279774599 0.026468078362993117 4.1706375942162813e-10 9.379797546349346 -0.12833484462603528 PIFGGTVYHS(ph)PVSR ddPTM_A459_Selumetinib_30min_R2 2 PIFGGTVYHSPVSR 14 0 O43663-3;O43663-2;O43663-4;O43663;G3V3N7;H0YNE4 O43663-3 PRC1 Protein regulator of cytokinesis 1 1 PIFGGT(0.014)VYHS(0.982)PVS(0.004)R;PIFGGTVY(0.005)HS(0.925)PVS(0.07)R 151.73 0.00026206 12222800.0 65505.0 56371.0 62764.0 75375.0 62353.0 60579.0 81041.0 88547.0 71318.0 71995.0 True False 61864.49433729145 60694.474438666475 58725.83257227624 65108.794970872455 54519.658697107414 68923.20736859053 84809.56707969501 88804.65711025492 85583.59279141403 69916.31728452543 0.8848362834319924 0.8681017078126335 0.8399445916650707 0.9312389081637596 0.7797844739910842 0.9857957347511108 1.213015364275571 1.2701563892283274 1.2240861091571857 1.0 16.093341575039034 -7.104248968940952 3.448448621509644 1.1990112744162098 0.8644177442938556 0.7858502376110843 0.07719633103667263 0.10104342434293165 2.2328878276584665 0.029702450188455017 0.022740071260082966 7.865947275487757e-08 7.104248968940952 -0.33459353012235415 PIGPDDAIDALSSDFTCGS(ph)PTAAGK ddPTM_A459_Selumetinib_30min_R1 1 PIGPDDAIDALSSDFTCGSPTAAGK 25 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4;P20810-5;F8W7E0;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 PIGPDDAIDALSSDFT(0.022)CGS(0.939)PT(0.038)AAGK 154.14 7.6947e-11 7987200.0 2126.5 2942.1 1698.8 1636.3 1555.5 1706.0 2599.1 2091.3 1162.7 2452.9 True False 2176.043312551294 2597.6375642548164 1468.1122908404488 1350.550922155152 1414.8052996458302 1688.8391889240654 2403.0477944525846 2035.8319305002303 1973.0169797519009 2767.753608269314 0.7862127994521816 0.9385364204724597 0.5304346046028514 0.48795923095179566 0.5111745841171581 0.61018407992614 0.8682303898992001 0.735553889052011 0.7128586062924999 1.0 11.434499801354283 -8.964884992324627 0.6587398885352198 1.0021929458075625 0.6581248441475243 0.3141924746166733 0.1430104137506385 2.1301178769208526 1.6503645721526516 0.1869071200088512 0.06366604393836309 1.0842139920919889e-09 8.964884992324627 -0.3440681016600382 PIGPDDAIDALSSDFTCGS(ph)PTAAGK ddPTM_A459_Selumetinib_30min_R2 2 PIGPDDAIDALSSDFTCGSPTAAGK 25 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;E9PDE4;P20810-5;F8W7E0;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 PIGPDDAIDALSS(0.003)DFT(0.044)CGS(0.938)PT(0.015)AAGK;PIGPDDAIDALSS(0.002)DFT(0.236)CGS(0.755)PT(0.007)AAGK 138.95 1.8976e-08 8895200.0 60341.0 42705.0 51257.0 55393.0 54518.0 49014.0 65849.0 62526.0 49393.0 50472.0 True False 56987.4887841616 45980.336181782346 47959.180424401966 47848.37784174512 47668.96144289615 55765.23359520776 68911.10897731817 62707.94030826345 59272.98015572948 49014.74221799523 1.1626601753959498 0.9380919719475984 0.9784644018140787 0.976203804743833 0.9725433468748309 1.1377236943772842 1.4059261736159496 1.2793689708571174 1.2092888276778093 1.0 15.580928115022068 -6.957319910208898 4.657114709798274 1.250655844092643 1.0006310962297031 0.4579800499476142 0.11049434525126012 0.15421748920778586 7.544765704484648 0.03908389365207107 0.03359076143748376 1.1032656324495805e-07 6.957319910208898 -0.2500247478629398 PIPNQPPTAAHTANFLLNASGS(ph)TSTPAPSR ddPTM_A459_Selumetinib_30min_R2 1 PIPNQPPTAAHTANFLLNASGSTSTPAPSR 30 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 1 PIPNQPPTAAHTANFLLNAS(0.159)GS(0.22)T(0.22)S(0.22)T(0.175)PAPS(0.007)R 72.878 7.7767e-05 10486000.0 40647.0 27528.0 28009.0 42795.0 40241.0 45151.0 43315.0 47050.0 44614.0 33207.0 True False 38388.00246283315 29639.309083528984 26206.931433893413 36966.24717450728 35185.56582089557 51370.14041003031 45329.233327044225 47186.9077104532 53538.046619312765 32248.227627852404 1.190391078413187 0.9190988548446573 0.8126626906856365 1.1463032201676715 1.0910852598456053 1.592960115602215 1.4056348724074967 1.4632403447096247 1.6601857080998959 1.0 14.97693225131718 -6.646597089551306 5.1650060151611585 1.4509528959599776 1.0098536552559798 0.5094666513021948 0.1922689912506775 0.15882949857395673 6.5502506136865435 0.06243120188232946 0.062134875679429186 2.2563315205090198e-07 6.646597089551306 -0.44109924070399775 PIPNQPPTAAHTANFLLNASGSTS(ph)TPAPSR ddPTM_A459_Selumetinib_30min_R2 1 PIPNQPPTAAHTANFLLNASGSTSTPAPSR 30 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 1 PIPNQPPTAAHTANFLLNAS(0.03)GS(0.031)T(0.101)S(0.464)T(0.334)PAPS(0.041)R 115.9 1.0225e-15 12057000.0 17257.0 10395.0 13868.0 15739.0 16557.0 16441.0 19023.0 21677.0 19423.0 13274.0 True False 16297.925025244469 11192.26307480687 12975.74797833674 13595.321048710613 14476.961638541978 18705.59851346167 19907.6071933594 21740.076481179465 23308.142723963578 12890.745130006111 1.2643120983989808 0.8682401957319253 1.006594098903776 1.0546575013002502 1.1230508005967468 1.451087452650055 1.544333317631109 1.6864871861111073 1.8081299792134302 1.0 13.654048038461953 -6.782311974697707 2.3024939034322984 1.5662178229268107 1.0326126776554743 0.4944744128421572 0.21818031578617605 0.21946678745660203 2.3879553908020323 0.08143919842969045 0.07418733069760987 1.6507755404230102e-07 6.782311974697707 -0.5336051452713364 PIPNQPPTAAHTANFLLNASGSTST(ph)PAPSR ddPTM_A459_Selumetinib_30min_R1 2 PIPNQPPTAAHTANFLLNASGSTSTPAPSR 30 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 1 PIPNQPPTAAHTANFLLNAS(0.094)GS(0.161)T(0.161)S(0.161)T(0.411)PAPS(0.01)R;PIPNQPPTAAHTANFLLNAS(0.021)GS(0.167)T(0.167)S(0.167)T(0.471)PAPS(0.009)R 167.78 2.1585e-27 81997000.0 4332.7 8680.9 4185.2 4486.4 4230.9 4183.2 5355.700000000001 5001.299999999999 2629.2 5512.7 True False 4433.643480033385 7664.536192359077 3616.8728276580196 3702.934460158205 3848.2158420260644 4141.120806041707 4951.715237101195 4868.649277488071 4461.560370829702 6220.308743245237 0.7127690381683981 1.232179383488345 0.5814619461752051 0.5952975347372105 0.6186535107610088 0.6657420036487154 0.796056183300928 0.7827021902690986 0.717257061504319 1.0 12.60277047455083 -10.357552774662633 16.020672296443824 0.9999994736179549 0.7464283785706283 0.1571119623325804 0.17737187709693714 0.0 0.0 0.17904892927400218 0.04342574397355631 4.389825180555403e-11 10.357552774662633 -0.25357109504732667 PIPQT(ph)PESAGNK ddPTM_A459_Selumetinib_30min_R1 2 PIPQTPESAGNK 12 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 PIPQT(0.924)PES(0.076)AGNK;PIPQT(0.795)PES(0.205)AGNK 181.76 0.00024352 19469000.0 5979.1 8567.5 4291.9 4247.1 4630.5 4975.4 6666.0 7180.7 3230.5 7354.8 True False 6118.401396696658 7564.4131170773035 3709.083553719164 3505.423712940873 4211.672092581175 4925.351993301755 6163.17825317261 6990.244509799169 5481.9225536153 8298.860221818719 0.7372580370266548 0.9115002439961015 0.446938911438408 0.42239821122961985 0.5075000638651768 0.5934974034569713 0.7426535799420818 0.8423138024931376 0.6605633071397751 1.0 13.018697492779046 -7.40131276606339 3.26758277761077 0.8120266912821976 0.5973416941150202 0.31147648785778415 0.15466253629819932 0.3789982175944933 7.5729833745811135 0.07902740917535617 0.04954570558439068 3.969056068186164e-08 7.40131276606339 -0.21468499716717737 PIPQT(ph)PESAGNK ddPTM_A459_Selumetinib_30min_R2 3 PIPQTPESAGNK 12 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 PIPQT(0.896)PES(0.104)AGNK;PIPQT(0.595)PES(0.405)AGNK;PIPQT(0.79)PES(0.21)AGNK 143.31 0.001956 51186000.0 175277.0 108349.0 134142.0 146473.0 153907.0 130034.0 178947.0 173312.0 133263.0 148749.0 True False 165535.80602942425 116659.01990305426 125511.44976276653 126523.1247199814 134571.8267139626 147945.00316887526 187268.39007675348 173816.30922665403 159919.32367932668 144454.2298736837 1.1459394866746033 0.8075846585113178 0.8688665598267252 0.8758699889274135 0.9315879973306239 1.024165254961686 1.296385645754424 1.2032621639300258 1.10705878131202 1.0 17.140252923603732 -6.992292611847331 3.887422509723384 1.1693608988365922 0.9153404671556684 0.4801056252454968 0.10935410484947239 0.17003654586982306 5.7810012477986 0.04094468159505225 0.033843838561957634 1.0179053293211113e-07 6.992292611847331 -0.2540204316809238 PIPQTPES(ph)AGNK ddPTM_A459_Selumetinib_30min_R1 1 PIPQTPESAGNK 12 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 PIPQT(0.226)PES(0.774)AGNK 138.2 0.0012603 11772000.0 5005.6 7188.3 2975.4 3244.3 3841.7 3761.8 5472.3 5300.8 2627.8 6069.9 True False 5122.220740797908 6346.69049424999 2571.357022702302 2677.7439080535128 3494.2189133072243 3723.959707441117 5059.520005225995 5160.205564574966 4459.184673081657 6849.03079083285 0.7478752683742921 0.9266552725598457 0.3754337075172679 0.39096683747393346 0.5101771360093891 0.5437206841624199 0.73872058101972 0.7534212828305127 0.65106798454609 1.0 12.74168413080978 -8.835733005710587 0.6851984228803241 0.9985318068416034 0.5892077652459458 0.33749417492632394 0.1625060817745987 1.5462083894635754 1.4218195652094279 0.19186123875597774 0.06979804260221663 1.4597113815695457e-09 8.835733005710587 -0.4093240415956576 PIPQTPES(ph)AGNK ddPTM_A459_Selumetinib_30min_R2 1 PIPQTPESAGNK 12 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 PIPQT(0.219)PES(0.781)AGNK 153.49 0.0004675 27825000.0 70554.0 36944.0 49469.0 54114.0 48823.0 42150.0 61093.0 68660.0 48928.0 45082.0 True False 66632.89113003988 39777.486006317005 46286.21839777475 46743.57984814318 42689.418256842124 47955.77990039592 63933.9455534829 68859.78923272513 58714.96716254392 43780.36552289708 1.521981151463684 0.9085690704321193 1.0572369107692148 1.0676836360284918 0.9750813577496426 1.0953718482618675 1.460333754409737 1.5728463755450268 1.3411255584843407 1.0 15.417996379200094 -7.251383499345779 22.737455190799427 1.3913136112278062 1.0857427985697283 0.2274929255917314 0.20701085652695217 230.98542377168891 522284.65524811146 0.07659982899265395 0.05847501737536814 5.605527669737085e-08 7.251383499345779 -0.30557081265807784 PIRPGQHPAASPT(ph)HPSAIR ddPTM_A459_Selumetinib_30min_R2 1 PIRPGQHPAASPTHPSAIR 19 1 P33176 P33176 KIF5B Kinesin-1 heavy chain 1 PIRPGQHPAAS(0.398)PT(0.601)HPS(0.001)AIR 71.946 0.0076964 13309000.0 28252.0 18200.0 41487.0 55763.0 66706.0 41896.0 41966.0 41257.0 47728.0 55403.0 True False 26681.866941716795 19595.88147777635 38817.771587630246 48167.98320345951 58325.795920793615 47666.79370597838 43917.502154051435 41377.05103953597 57274.9336317425 53803.3714357186 0.4959144051705917 0.36421289140195356 0.721474705985807 0.8952595705086631 1.0840546672893567 0.8859443643402184 0.8162592971803212 0.7690419751663901 1.0645231349520825 1.0 15.715408957558036 -5.487975222944941 2.8163756448517834 0.9205883624953478 0.4295192319935986 0.7964468251694073 0.10047527460903492 0.1174931078505167 1.8425923303830176 0.029145002367406796 0.06656550651067142 3.251058445601554e-06 5.487975222944941 -0.4910691305017492 PIS(ph)PGLSYASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R1 2 PISPGLSYASHTVGFTPPTSLTR 23 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 PIS(0.898)PGLS(0.056)Y(0.033)AS(0.013)HTVGFTPPTSLTR;PIS(0.895)PGLS(0.055)Y(0.046)AS(0.003)HTVGFTPPTSLTR 128.4 5.8019e-06 54594000.0 2681.3 3341.7 2620.5 2839.5 2611.9 2786.8 3035.3 2936.5 1167.54 2338.3 True False 2743.769073098415 2950.452210485817 2264.650493376145 2343.634629016412 2375.6541061683993 2758.7673222119492 2806.3448772659494 2858.61448090371 1981.2301062522856 2638.4435819707855 1.039919554030773 1.1182548039484614 0.8583281859241289 0.8882640678887793 0.9003998123749549 1.0456040603116812 1.063636492530096 1.083447264302869 0.7509086492470708 1.0 11.365471419270932 -5.243668818414597 24.865685073505745 0.955468470669052 1.0790871876414854 0.2111940481593937 0.10004225878180209 1312.614604259145 1836685.6244662977 0.026377996719734256 0.0694393470048963 5.705992304287689e-06 5.243668818414597 0.12361871697243332 PIS(ph)PGLSYASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R2 1 PISPGLSYASHTVGFTPPTSLTR 23 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 PIS(0.48)PGLS(0.48)Y(0.035)AS(0.006)HTVGFTPPTSLTR 87.881 0.00014779 12390000.0 5353.0 3800.2 5715.4 5578.1 5796.5 4322.1 3791.8 6380.6 4240.0 6741.3 True False 5055.501689756832 4091.663120431079 5347.677386457011 4818.353157240778 5068.291848632514 4917.430042882596 3968.126213309162 6399.166489634806 5088.118475498412 6546.661152999117 0.7722259594023491 0.624999984695501 0.8168556858952698 0.7360016112997422 0.7741796513037275 0.7511355678810187 0.6061297691406111 0.9774702462954353 0.7772081610131104 1.0 12.676543593428326 -8.444694973767556 0.8710628015441629 0.9909414224313116 0.7318211194386556 0.41338995343427876 0.09246494964878353 0.5604120190129768 0.9474681227882873 0.08415212638755662 0.030097430815607663 3.591741116028566e-09 8.444694973767556 -0.259120302992656 PKPS(ph)SSPVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 1 PKPSSSPVIFAGGQDR 16 1 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 PKPS(0.42)S(0.42)S(0.16)PVIFAGGQDR 104.78 0.017955000000000002 3685200.0 14391.0 9450.5 13288.0 14507.0 14320.0 13015.0 15846.0 14735.0 13402.0 11910.0 True False 13591.205831737449 10175.322961853046 12433.064546880492 12531.121574029152 12520.99357757571 14807.698111593192 16582.87039825333 14777.876410489433 16082.774483167379 11566.127354103728 1.1750869946037046 0.8797519385987724 1.07495483719269 1.0834327852687042 1.0825571251498618 1.2802641418555136 1.433744406451623 1.2776857765833054 1.3905064323419472 1.0 13.49761827232061 -6.74376727923758 3.8132095800274435 1.3067754910206806 1.0470051185831453 0.4104216284229104 0.12830827522801774 0.18798539081494453 5.91689336858219 0.04298941723986519 0.04063964152951734 1.803984163699568e-07 6.74376727923758 -0.2597703724375353 PKPSS(ph)SPVIFAGGQLTK ddPTM_A459_Selumetinib_30min_R2 1 PKPSSSPVIFAGGQLTK 17 1 H3BRU6;F8VZX2 H3BRU6 PCBP2 1 PKPS(0.264)S(0.368)S(0.368)PVIFAGGQLTK 71.428 0.016344 2656400.0 26721.0 22836.0 23374.0 25206.0 28282.0 18164.0 27693.0 26441.0 24958.0 20853.0 True False 25235.953792638207 24587.447770686842 21870.142287686987 21772.899317224706 24728.962315712022 20665.92612362497 28980.779372638466 26517.938932456807 29950.29738478522 20250.91970739923 1.2461633425674765 1.2141398082627894 1.0799579773997194 1.0751560734927699 1.2211278634755842 1.020493213257574 1.4310846021501702 1.3094683755408774 1.4789598604670808 1.0 14.305699809876266 -7.265696481253144 24.99912439360294 1.3306672384165745 1.1437043892444516 0.24373087947314132 0.1368435010333808 457.13337747111035 2684425.3447134285 0.05285491230519036 0.03702425487793425 5.4237981515566015e-08 7.265696481253144 -0.1869628491721229 PKPSSS(ph)PVIFAGGQDR ddPTM_A459_Selumetinib_30min_R1 1 PKPSSSPVIFAGGQDR 16 1 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 PKPS(0.008)S(0.171)S(0.821)PVIFAGGQDR 147.49 0.001499 24862000.0 2260.8 3759.5 1695.1 1965.6 1499.9 1312.0 2197.0 2654.7 1039.5 2906.2 True False 2313.4722412489828 3319.335992255868 1464.9147305178033 1622.3448588817257 1364.2343098288532 1298.8024712006877 2031.2785211851517 2584.2887323191135 1763.9555779238842 3279.2390787852264 0.7054905682893954 1.0122275053777094 0.44672397935086566 0.4947321070236554 0.4160216065533792 0.39606824632067417 0.6194359338806202 0.7880757304455054 0.5379161249131401 1.0 11.679145372487632 -10.594704961559131 7.345033511075735 1.0000000607919148 0.6006870739828601 0.301398221084595 0.18183971196736862 1.9679459458673794e-07 2.485254378043365e-08 0.1914099364400086 0.04642372165501786 2.5426995046770944e-11 10.594704961559131 -0.3993129868090547 PKPSSS(ph)PVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 1 PKPSSSPVIFAGGQDR 16 1 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 PKPS(0.005)S(0.067)S(0.928)PVIFAGGQDR 208.52 2.9492e-07 10208000.0 35685.0 25547.0 26950.0 32935.0 32097.0 27910.0 35131.0 35402.0 31013.0 25183.0 True False 33701.77055837335 27506.37275344794 25216.0663409414 28449.196183956028 28064.687909179323 31754.34915824559 36764.66111075586 35505.01395888341 37216.466575620776 24455.90135670816 1.3780629086945952 1.1247335500845503 1.0310830900544474 1.1632855305148064 1.1475630155615297 1.2984329914928894 1.5033042771360152 1.4517973981418815 1.5217785692209804 1.0 14.577895017763852 -6.941576008022756 3.7737825867246864 1.4072342700550973 1.1591802191884704 0.2457835881689443 0.16017846480068548 0.2572107081621092 7.506660756633984 0.05773424948921605 0.049344575547450004 1.1439946461410325e-07 6.941576008022756 -0.2480540508666269 PLEGSSSEDSPPEGQAPPS(ph)HSPR ddPTM_A459_Selumetinib_30min_R1 1 PLEGSSSEDSPPEGQAPPSHSPR 23 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 PLEGSSSEDSPPEGQAPPS(0.617)HS(0.383)PR 109.32 1.1226e-05 20739000.0 2154.2 3054.0 2268.7 2758.4 2262.7 2029.2 2702.4 2415.8 1077.1 2664.3 True False 2204.3886686564756 2696.436260233919 1960.6230010770676 2276.697221580866 2058.0391845121303 2008.7880903661842 2498.555792285279 2351.7251363756786 1827.760031728538 3006.2888574796916 0.7332591022223043 0.8969318611966196 0.6521738575449955 0.7573115324285653 0.6845779903656624 0.6681953017815602 0.8311096873039445 0.7822685203800531 0.6079788464708052 1.0 11.553767921072735 -10.772032046477495 4.511810070531901 1.0001006880545447 0.7386467308846569 0.48027865522862445 0.0826573221896873 8.791754407083732e-05 1.4631131752606081e-05 0.07906223472035452 0.019167582404708148 1.6903161990461784e-11 10.772032046477495 -0.26145395716988773 PLEGSSSEDSPPEGQAPPSHS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 PLEGSSSEDSPPEGQAPPSHSPR 23 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 PLEGSSSEDSPPEGQAPPS(0.178)HS(0.822)PR 164.99 4.5752e-11 16536000.0 3780.0 5322.6 4186.1 4156.5 3950.1 3424.7 4182.9 4339.2 2218.8 3914.1 True False 3868.0666454003717 4699.427517590394 3617.6506126013674 3430.6453021682373 3592.814152446799 3390.2506273788076 3867.38048532789 4224.110320291974 3765.1415452597544 4416.512861562605 0.8758191737795171 1.0640583792905995 0.8191192295818215 0.7767769300584447 0.8134956842796619 0.7676306474468872 0.875663811371665 0.9564356433907095 0.852514565966329 1.0 12.108691997509887 -9.970482459430022 9.453407510008114 0.9999692887900251 0.8669918388504909 0.18488130314838824 0.08388273615704098 0.0 0.0 0.08789820366423755 0.02131844576527675 1.0703296112117676e-10 9.970482459430022 -0.1329774499395342 PLEGSSSEDSPPEGQAPPSHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 PLEGSSSEDSPPEGQAPPSHSPR 23 0 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 PLEGSSSEDSPPEGQAPPS(0.008)HS(0.992)PR;PLEGSSSEDSPPEGQAPPS(0.239)HS(0.761)PR;PLEGSSSEDSPPEGQAPPS(0.269)HS(0.731)PR;PLEGSSSEDSPPEGQAPPS(0.017)HS(0.983)PR 186.27 2.9998e-22 95509000.0 240451.0 192998.0 224195.0 245857.0 256554.0 213027.0 241106.0 272313.0 206084.0 210129.0 True False 227087.69602161756 207800.32601361995 209770.5377850591 212370.85247301857 224323.3928981394 242369.53558343145 252317.9067424751 273105.38574615616 247306.55846806912 204062.02978929188 1.1128366029491192 1.0183194111525213 1.0279743762309022 1.0407171421959593 1.0992902164590286 1.1877248101162903 1.2364765115931207 1.338344943584832 1.211918546156922 1.0 17.638648236764176 -6.710785397334022 2.3312737104160814 1.2240047395103228 1.046779103713131 0.39014581992954034 0.0832741419648627 0.25170010966775885 2.803798791426417 0.030452215787113227 0.029034918752901696 1.946321601146933e-07 6.710785397334022 -0.17722563579719175 PLISVYSEK ddPTM_A459_Selumetinib_30min_R2 1 PLISVYSEK 9 0 P36578;H3BU31;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 151.44 0.00072364 0.0 24902.0 20224.0 23702.0 23808.0 19418.0 15533.0 21505.0 21984.0 15300.0 23696.0 False True 23518.04653060425 21775.115769590582 22177.03912478637 20565.30932890921 16978.537240877456 17672.529755465006 22505.025111349078 22047.969800352876 18360.42751771832 23011.83491039813 1.021997881619487 0.9462572565107042 0.9637231976996954 0.8936840286307011 0.7378176189333573 0.7679756883480636 0.977976123980446 0.9581143740254402 0.79786890481393 1.0 14.49008840485798 -5.790448498077372 3.9418393496704707 0.8669953140337621 0.9764131356158752 0.22846295917747794 0.08530509975602028 0.3327696060034464 11.140136597484375 0.025790592134592557 0.0421563916462274 1.6201361104991697e-06 5.790448498077372 0.1094178215821131 PLLS(ph)PEER ddPTM_A459_Selumetinib_30min_R1 1 PLLSPEER 8 0 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 PLLS(1)PEER 91.867 0.026264 2291300.0 884.81 1147.1 838.04 877.03 1041.9 915.89 1493.6 1267.3 944.97 1063.0 True False 905.4243514594453 1012.7969987276779 724.2387710242103 723.8731743920629 947.660328962385 906.6769781615836 1380.936549495742 1233.6870872294471 1603.5450721219179 1199.446404496833 0.7548685360720808 0.8443870396631398 0.6038108650031995 0.6035060605277541 0.7900814287403929 0.7559128734409221 1.151311592013187 1.0285470718860323 1.336904313615083 1.0 10.228152979021974 -7.229800516015311 4.65293007586741 1.1338390719776616 0.7192344601751186 0.7652583598140702 0.1095761420048768 0.09764745508605036 5.334841564891901 0.044422034860680006 0.03274458852365339 5.891141903618107e-08 7.229800516015311 -0.41460461180254304 PLLS(ph)PIPELPEVPEMT(ph)PSIPSIRR ddPTM_A459_Selumetinib_30min_R2 1 PLLSPIPELPEVPEMTPSIPSIRR 24 1 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 2 PLLS(1)PIPELPEVPEMT(0.333)PS(0.333)IPS(0.333)IRR 41.521 0.040939 8308100.0 6857.2 7965.8 24929.0 28128.0 42873.0 25309.0 9464.9 21499.0 35136.0 26790.0 True False 6476.10427554652 8576.751245915973 23325.095280642963 24296.917876493557 37486.91045051702 28795.085017772722 9905.036604343546 21561.558530648952 42164.18178186607 26016.503091220704 0.24892293375630054 0.3296657977378292 0.8965499782526131 0.9339040604843076 1.440889666035364 1.1068007455425342 0.3807212894682226 0.828764667374722 1.6206706041172159 1.0 14.667139440298874 -5.288357002649492 2.5826665006068863 1.0267001387916068 0.2392664931494883 0.4713628731623237 0.3156894072395443 0.2762643432135917 3.546761122980717 0.09180561207171349 0.28425915008323877 5.148052857356215e-06 5.288357002649492 -0.7874336456421185 PLMRSS(ph)S(ph)KRHPMVS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 PLMRSSSKRHPMVSR 15 3 H0YNE5 H0YNE5 RMDN3 3 PLMRS(0.474)S(0.59)S(0.936)KRHPMVS(1)R 66.738 0.036916 0.0 624.17 709.4 862.94 872.08 1014.2 733.73 874.59 635.3 503.9 652.7 True False 638.7119465766007 626.3431182088874 745.7574877901204 719.7875989690552 922.4657890715534 726.3493423735367 808.6189721635513 618.4497802547679 855.0814966001392 736.4804028363902 0.8672490729104859 0.8504545617190442 1.012596512979845 0.9773343543113349 1.2525327021858041 0.9862439510626 1.09795042617473 0.8397369133964004 1.1610376777263636 1.0 9.52450332656754 -5.355486780826091 2.383188052831857 1.0462703917293947 0.8509573337796188 0.32231928122720277 0.10594506866241855 0.35958927627115683 3.88122682581864 0.02888139300558759 0.08479940025417737 4.410757885022824e-06 5.355486780826091 -0.19531305794977594 PLPS(ph)PGAAGAQALEK ddPTM_A459_Selumetinib_30min_R2 2 PLPSPGAAGAQALEK 15 0 H9KVB4;O15417;O15417-2;O15417-3 H9KVB4 TNRC18 Trinucleotide repeat-containing gene 18 protein 1 PLPS(1)PGAAGAQALEK;PLPS(1)PGAAGAQALEK 102.15 0.006480500000000001 11611900.0 43452.0 27690.0 36036.0 40637.0 37329.0 29225.0 30524.0 34730.0 27409.0 33981.0 True False 41037.111792137846 29813.733962616883 33717.482993030215 35102.17049726496 32639.39729450585 33250.47847186409 31943.426482158557 34831.058550138994 32891.56587144716 32999.8802367589 1.2435533552763076 0.9034497625057155 1.0217456169877843 1.0637059966709907 0.9890762348327705 1.0075939134720266 0.9679861336762201 1.0554904533059586 0.9967177345937428 1.0 15.010173168197888 -4.745935574455511 24.999986260868262 1.0038405022073704 1.2435540094818456 0.7440803022750715 0.042700820547352844 444.2993013133369 716396.2217955649 0.01042002140144311 0.2534915925352155 1.7949998868765797e-05 4.745935574455511 0.23971350727447516 PLPTFPT(ph)SECTSDVEPDTR ddPTM_A459_Selumetinib_30min_R1 1 PLPTFPTSECTSDVEPDTR 19 0 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 PLPT(0.002)FPT(0.411)S(0.411)ECT(0.089)S(0.089)DVEPDTR 75.89 0.021096 5107900.0 1081.3 1650.9 1113.1 1171.2 1188.4 1264.7 1532.5 1104.9 862.02 1427.3 True False 1106.4921861564603 1457.6118605174127 961.9471338206398 966.671906146865 1080.9094298290606 1251.9782662557243 1416.902291177171 1075.594462778992 1462.784980550213 1610.5078580793308 0.6870455059288239 0.9050634886412415 0.5972942814248945 0.6002279972105845 0.6711606058961662 0.7773810354137707 0.8797860153671954 0.6678604251342996 0.9082755934483362 1.0 10.653299984677707 -6.952459883281001 4.214750234204933 0.8360389593199099 0.6942833933928744 0.3315394963573134 0.11213246373784079 0.31055886327024085 11.809591207173483 0.04232881054409091 0.03623656188502776 1.115681204472935e-07 6.952459883281001 -0.14175556592703553 PLPTFPTS(ph)ECTSDVEPDTR ddPTM_A459_Selumetinib_30min_R1 1 PLPTFPTSECTSDVEPDTR 19 0 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 PLPT(0.001)FPT(0.065)S(0.536)ECT(0.101)S(0.289)DVEPDT(0.007)R 82.007 0.0053912 5949300.0 1050.7 1421.9 884.95 891.06 829.16 826.33 1103.9 988.67 438.59 994.0 True False 1075.179265693695 1255.4232869766233 764.7786506823958 735.4530982677809 754.1626244000879 818.0178704476094 1020.6319342450116 962.44725994724 744.2551966538103 1121.5895823799171 0.9586209452946742 1.119325024678566 0.6818703228854898 0.6557239027730735 0.672405161609846 0.7293379711247366 0.9099869954919856 0.8581100208732407 0.6635717809312783 1.0 10.131329139053156 -5.261455700450046 24.999999999942847 0.7620922303478279 1.0389729964764634 0.45360852837255494 0.11712300254894129 1.2031385570353754 1846143.1253619175 0.03075362898751861 0.07146392609915564 5.477019656209817e-06 5.261455700450046 0.27688076612863544 PLPTFPTS(ph)ECTSDVEPDTR ddPTM_A459_Selumetinib_30min_R2 1 PLPTFPTSECTSDVEPDTR 19 0 Q8TDD1-2;Q8TDD1;H0YHZ9 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 PLPTFPT(0.039)S(0.461)ECT(0.461)S(0.039)DVEPDTR 122.46 0.00042049 2823500.0 23601.0 14260.0 14253.0 22108.0 19383.0 16867.0 22658.0 19216.0 21836.0 18283.0 True False 22289.350902288614 15353.696146873115 13335.97749749305 19096.85226157279 16947.93425378142 19190.27614661871 23711.64189597523 19271.915378619957 26203.810148816803 17755.12228506115 1.2553758033557723 0.8647474176954246 0.7511059221886469 1.075568613663706 0.954537737430348 1.0808304126840667 1.335481756491522 1.0854284791288096 1.475845095748185 1.0 14.115947676232961 -7.011494633631567 4.025206463589426 1.231120909777656 0.9681258108521745 0.30469646215346624 0.17266781395508615 0.25278846361963186 9.379727104271177 0.06441717109751108 0.05245096235377582 9.738798190197065e-08 7.011494633631567 -0.26299509892548156 PLRAPS(ph)PEPAAPR ddPTM_A459_Selumetinib_30min_R2 2 PLRAPSPEPAAPR 13 1 P20749 P20749 BCL3 B-cell lymphoma 3 protein 1 PLRAPS(1)PEPAAPR;PLRAPS(1)PEPAAPR 102.15 0.0052425 11892800.0 18588.1 79269.0 83152.0 69483.0 50467.0 10463.4 10972.6 10079.2 11302.5 51902.0 True False 17555.047816059963 85348.67740999172 77802.09084905218 60019.29553513935 44126.884279295635 11904.638372711817 11482.847641794422 10108.52880329861 13563.315818236038 50403.454402409014 0.3482905690531585 1.6933100800708714 1.5435864817498235 1.190777422832169 0.8754734135283118 0.23618695412556565 0.22781866397723732 0.20055230188380654 0.2690949653956215 1.0 15.621234991815188 -6.550222001457688 2.841876582467163 0.32616564376296914 1.250788477403977 0.47008048324752294 0.4002186208739359 0.20947418974661447 3.4470380685519637 0.1368074038451771 0.14345104172306253 2.8169426061984545e-07 6.550222001457688 0.9246228336410078 PLS(ph)LIGSTLR ddPTM_A459_Selumetinib_30min_R1 2 PLSLIGSTLR 10 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 PLS(0.968)LIGS(0.016)T(0.016)LR;PLS(1)LIGSTLR 126.03 0.003526300000000001 8249500.0 2807.8 3376.8 3264.8 3158.2 2962.7 3203.7 3029.8 2983.5 1785.25 2619.7 True False 2873.216276972266 2981.442686168269 2821.4580922627133 2606.6796567563424 2694.72430810717 3171.4736867268625 2801.2597466940247 2904.367888226193 3029.438860498908 2955.9640130388993 0.9720065143886634 1.0086194124884411 0.9544967664752094 0.8818374125186075 0.9116228398656451 1.0729067311839182 0.9476636841103387 0.9825450768057008 1.0248564756322835 1.0 11.52941299036863 -6.7323035955174895 24.998166049724357 1.0008829146734928 0.9461501484698831 0.31894909398496085 0.04347461027040379 308.5825576993394 264759.48399588146 0.01544326745617337 0.015440673895482945 1.852236356552534e-07 6.7323035955174895 -0.05473276620360967 PLS(ph)PANVPALPGETVTSPVR ddPTM_A459_Selumetinib_30min_R2 1 PLSPANVPALPGETVTSPVR 20 0 Q8IY33;Q8IY33-5;Q8IY33-3 Q8IY33 MICALL2 MICAL-like protein 2 1 PLS(1)PANVPALPGETVTSPVR 91.067 0.0042005 0.0 2993.3 2742.6 3008.7 3086.2 1043.7 2800.2 2581.4 3356.7 2735.4 2101.2 True False 2826.944369129296 2952.948601151064 2815.123517624874 2665.854236008049 912.5810752036159 3185.9021323152706 2701.440214947062 3366.4674412684 3282.556433461875 2040.5328964267633 1.3853951455914486 1.4471457952587083 1.3796021238150675 1.3064500164032171 0.4472268380488564 1.561308880584183 1.3238895681013685 1.6497981714303744 1.6086760665363715 1.0 10.994730253836485 PLT(ph)YPQYSPPQPR ddPTM_A459_Selumetinib_30min_R2 1 PLTYPQYSPPQPR 13 0 E9PPX2;P15407;E9PKL5 E9PPX2 FOSL1 Fos-related antigen 1 1 PLT(0.901)YPQY(0.003)S(0.096)PPQPR 101.53 0.023476 4966100.0 24626.0 16729.0 17868.0 17956.0 18601.0 20216.0 24938.0 18494.0 21785.0 18893.0 True False 23257.385505688708 18012.06050778683 16718.392333207452 15510.361824172282 16264.176084950126 23000.570497423607 26097.666413709532 18547.81447815349 26142.608723757734 18347.51000009081 1.2676044599825043 0.9817168927935007 0.911207697018544 0.8453660373585034 0.8864514086581573 1.2536071923279926 1.4224091668886059 1.0109172567864353 1.424858671483397 1.0 14.163296663093588 -6.769764334898857 24.992672256231423 1.2355440077146471 0.9675183369761714 0.3352546434192115 0.1708626088505805 201.76068326185535 605709.8956092129 0.058976061944180674 0.05287013232776076 1.6991654356872945e-07 6.769764334898857 -0.2680256707384757 PLTS(ph)PESLSR ddPTM_A459_Selumetinib_30min_R2 3 PLTSPESLSR 10 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 PLT(0.123)S(0.877)PESLSR;PLT(0.024)S(0.976)PESLSR;PLT(0.007)S(0.993)PESLSR 163.46 0.00039167 18333200.0 96818.0 82081.0 91505.0 102574.0 110588.0 73831.0 105253.0 90404.0 82280.0 87887.0 True False 91437.24315316202 88376.34876798699 85617.66792311099 88603.2442499802 96694.94677073628 84000.55007891174 110147.47305486277 90667.06067281205 98738.29909528536 85349.47395215054 1.0713275538689842 1.0354644812167606 1.0031423037371128 1.0381229098102447 1.132929616238131 0.9841952877882405 1.2905465957132287 1.0623036847730627 1.1568706229008627 1.0 16.381094640840395 -6.616840467928241 1.4192807000483125 1.1222514694647117 1.0365069059751548 0.11278831710229809 0.0835013543958331 0.7548843724913101 3.157557863419934 0.03465801212113196 0.03551132497530059 2.416348283563445e-07 6.616840467928241 -0.08574456348955684 PLTS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 1 PLTSPLR 7 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 PLT(0.137)S(0.863)PLR 82.241 0.041528 23314000.0 207820.0 168830.0 191430.0 189320.0 176740.0 153400.0 176600.0 180960.0 160490.0 176760.0 True False 196270.19636937487 181778.71812598806 179113.60221322475 163534.2894047837 154536.3411243527 174529.45757344557 184812.24992626108 181486.56364045935 192592.48446526888 171656.4795223654 1.143389383934106 1.0589679960336353 1.0434421276237797 0.9526834632739659 0.9002651199322651 1.0167367876766098 1.0766401037729636 1.057266024244737 1.1219645480389553 1.0 17.3891647902135 -10.083797999084364 13.706695420332554 0.999999974031106 1.035884361499463 0.026157933304304937 0.06881635426085461 0.0 0.0 0.0732964675345419 0.01777700456644541 8.245215308355676e-11 10.083797999084364 0.03588438746835709 PLTYPQYS(ph)PPQPR ddPTM_A459_Selumetinib_30min_R2 1 PLTYPQYSPPQPR 13 0 E9PPX2;P15407;E9PKL5 E9PPX2 FOSL1 Fos-related antigen 1 1 PLT(0.009)YPQYS(0.991)PPQPR 139.64 0.00092431 5557900.0 29825.0 18563.0 19278.0 21092.0 20578.0 23310.0 25033.0 24782.0 21914.0 20631.0 True False 28167.445898934708 19986.722410547387 18037.67446829938 18219.233214270545 17992.807670345876 26520.740912888006 26197.084101948476 24854.11151711905 26297.41232831892 20035.32942422452 1.4058888327974146 0.9975739348903161 0.9002933810756416 0.909355310736336 0.8980539969854924 1.3236987698750806 1.307544465441823 1.2405142431582976 1.3125520310398777 1.0 14.290258610545408 -6.767425920062134 24.986798533796264 1.2563117219652526 1.007817716907035 0.29505763128536777 0.1637510563568318 167.51650081523442 699180.6339057442 0.05770936667964797 0.052207392572043335 1.7083390957655642e-07 6.767425920062134 -0.24849400505821762 PMEEDGEEKS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 PMEEDGEEKSPSK 13 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 PMEEDGEEKS(0.85)PS(0.15)K;PMEEDGEEKS(0.984)PS(0.016)K 201.06 0.00048446 25311000.0 4309.7 5453.5 4991.6 5068.5 2611.8 4200.200000000001 3949.3 4497.1 3556.8 4955.6 True False 4410.10762478359 4815.0016847366305 4313.768136896153 4183.381622528503 2375.5631511507427 4157.949801476472 3651.401121400328 4377.82229936049 6035.629821606227 5591.699531631706 0.788688233306535 0.8610980717934913 0.7714592160207432 0.7481413475211812 0.42483741082874904 0.7435932095341229 0.6530038140899208 0.7829144385522812 1.0793909414236673 1.0 12.449071124654541 -8.163418092719064 4.159070560537632 1.0392133236627752 0.7128294820440542 0.5702960130439803 0.11145647664437987 0.17341959898820306 5.060166391544847 0.0914397773822143 0.031110690291624075 6.864073215850155e-09 8.163418092719064 -0.326383841618721 PMEEDGEEKS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 PMEEDGEEKSPSK 13 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 PMEEDGEEKS(0.5)PS(0.5)K 173.33 0.00072312 4003700.0 27304.0 20694.0 14768.0 16271.0 13573.0 15023.0 23443.0 20622.0 11094.0 16680.0 True False 25786.552986572093 22281.1632583024 13817.842958182648 14054.861730959425 11867.838395840443 17092.281884784054 24533.14595142324 20682.006605844126 13313.10999225928 16198.405060155344 1.5919192593844667 1.3755158718131673 0.8530372531658456 0.8676694821968254 0.7326547491414953 1.0551830147047907 1.5145408366018454 1.276792778612352 0.8218778295035182 1.0 13.98356414790116 -5.059910541778831 4.354101029001375 1.0301907387678444 1.555005876981489 0.42980689775988523 0.22137372568158992 0.21286307247874753 8.056054043032436 0.06431824191333843 0.20794542639510535 8.711430140148943e-06 5.059910541778831 0.5248151382136446 PMEEDGEEKSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 PMEEDGEEKSPSK 13 1 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 PMEEDGEEKS(0.178)PS(0.822)K 124.81 0.010403 4738000.0 45786.0 36018.0 28223.0 30562.0 24704.0 24152.0 36614.0 36999.0 21240.0 32673.0 True False 43241.39741588012 38780.46478387627 26407.162906879003 26399.402877609355 21600.46266343787 27478.718769973024 38316.62354926462 37106.66096448583 25488.593495185436 31729.645595351045 1.3628074503995011 1.22221550402562 0.8322552115346703 0.8320106443759755 0.68076596060697 0.8660266528157864 1.2075969595726808 1.1694634550195737 0.8033053321881404 1.0 14.953543786695798 -5.104629246983632 4.105952993922849 0.9269060504674493 1.3366370971374262 0.48079725386941163 0.15582616863025894 0.20871243167646952 5.932841612740087 0.04538244400251033 0.14251057797162892 7.859062689247748e-06 5.104629246983632 0.40973104666997684 PMSS(ph)EELPLASSWR ddPTM_A459_Selumetinib_30min_R2 1 PMSSEELPLASSWR 14 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 PMS(0.341)S(0.644)EELPLAS(0.003)S(0.012)WR 89.26 0.019745 1388500.0 4422.1 6302.3 6117.6 5779.3 5819.2 4438.2 8180.4 5473.8 3530.0 5397.2 True False 4176.337385068874 6785.666144911528 5724.000276339259 4992.149370151418 5088.14007169194 5049.52176403173 8560.80480915508 5489.727851763631 4236.098636440892 5241.368812390314 0.7968028075407014 1.2946362654103978 1.0920811874195973 0.9524514585484322 0.9707655106551271 0.9633975293047365 1.6333147152167196 1.0473843853128997 0.808204648073416 1.0 12.35572791340244 PMT(ph)NEKQNS(ph)ILANIILS(ph)CLK ddPTM_A459_Selumetinib_30min_R1 1 PMTNEKQNSILANIILSCLK 20 1 Q8IVG5;Q8IVG5-2 Q8IVG5 SAMD9L Sterile alpha motif domain-containing protein 9-like 3 PMT(1)NEKQNS(1)ILANIILS(1)CLK 54.412 0.04106 11447000.0 329.51 288.53 528.79 300.14 367.51 334.13 290.65 284.87 201.19 255.4 True False 337.1869418851523 254.74877346604222 456.98322243555475 247.7261833255805 334.26878538916037 330.7689555657667 268.72603649634266 277.3143222118302 341.40473566378654 288.1830778066708 1.170044210962852 0.883982416333765 1.5857392665579222 0.8596139135267651 1.1599181601266901 1.147773693317499 0.9324837479757192 0.962285240071827 1.1846800244559113 1.0 8.17084181230623 -7.236610969504236 23.96769420591015 1.0167193417038425 1.1322940477605896 0.07601878014231522 0.19560227976978506 1284.1034180963698 1239588.4738407834 0.07206291032849697 0.05578852927207972 5.799479671830802e-08 7.236610969504236 0.11557470605674713 PNNSGEAPSS(ph)PTPK ddPTM_A459_Selumetinib_30min_R1 3 PNNSGEAPSSPTPK 14 0 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 PNNS(0.002)GEAPS(0.042)S(0.945)PT(0.011)PK;PNNSGEAPS(0.001)S(0.92)PT(0.079)PK;PNNSGEAPS(0.034)S(0.963)PT(0.003)PK 210.67 4.2028e-06 28550100.0 14387.7 20351.2 10281.400000000001 10744.9 9670.900000000001 11251.8 14058.4 13983.5 6914.4 16763.300000000003 True False 14722.905416409243 17968.472042983794 8885.242351687653 8868.504921753281 8796.16880253607 11138.617107816994 12997.963569517227 13612.612155190545 11733.231792204813 18915.032843369485 0.7783705975202808 0.9499572214215055 0.4697450131471648 0.4688601386627814 0.4650358725451274 0.5888764349527179 0.6871763679793748 0.7196716108247382 0.6203125254587017 1.0 14.207245660981684 -11.058784147280377 7.213326868326892 1.000163870128461 0.6350982363606157 0.35234262394642557 0.14689486400791493 0.0004288194074844456 2.7589556458465738e-05 0.15754790804449906 0.038194111685944866 8.73405359808927e-12 11.058784147280377 -0.3650656337678453 PNNSGEAPSS(ph)PTPK ddPTM_A459_Selumetinib_30min_R2 3 PNNSGEAPSSPTPK 14 0 P49916-4;P49916-3;P49916-2;P49916;K7ENR9;K7ERZ5 P49916-4 LIG3 DNA ligase 3 1 PNNSGEAPS(0.104)S(0.871)PT(0.025)PK;PNNS(0.002)GEAPS(0.121)S(0.877)PTPK;PNNSGEAPS(0.042)S(0.957)PT(0.001)PK 147.51 0.0004773 39837000.0 147177.0 107125.0 110633.0 121596.0 109572.0 102800.0 150462.0 157466.0 112635.0 106422.0 True False 138997.49153621166 115341.14303883481 103514.99322810267 105034.41503520007 95806.58577389152 116959.7668745125 157458.78113479688 157924.19999010055 135165.14728484978 103349.32034243701 1.3449289368876178 1.11603194541255 1.0016030379795118 1.0163048454230728 0.9270170859029024 1.1316936239829998 1.5235589417818511 1.528062298492486 1.3078474714395256 1.0 16.657169375616043 -7.120576165115517 5.913095960609936 1.382083757569772 1.0710394522419573 0.32558562443908545 0.17289364905518861 0.23308888702050962 10.35860544354254 0.06643097345912333 0.05136426847557985 7.575718607925238e-08 7.120576165115517 -0.3110443053278147 PNSSPS(ph)PSPGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R1 2 PNSSPSPSPGQASETPHPRPS 21 1 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 PNS(0.043)S(0.13)PS(0.645)PS(0.181)PGQASETPHPRPS;PNS(0.175)S(0.175)PS(0.519)PS(0.131)PGQASETPHPRPS 161.04 4.8205e-08 12110600.0 1599.28 2110.2200000000003 1305.58 1250.54 2174.2799999999997 1525.77 2274.7 1681.27 492.17999999999995 1465.34 True False 1636.5401123428328 1863.1544613853373 1128.2894070375985 1032.156664543118 1977.6167579003125 1510.4221390883174 2103.117547628522 1636.6772580653774 835.193512595072 1653.4306626203086 0.989784542733284 1.1268416048560903 0.6823929376327873 0.6242515564017582 1.1960687572868904 0.9135080008100519 1.271972024696556 0.989867488892228 0.505127630372768 1.0 10.691246831375718 -10.847257271723 3.749682197943495 1.0001846723786967 0.9324807647446066 0.007831748866199084 0.23866836285937262 176987210.72496098 93.15124897164878 302085.81560690276 0.05896816275399196 1.4214864632406995e-11 10.847257271723 -0.06770390763409007 PNSSPS(ph)PSPGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R2 2 PNSSPSPSPGQASETPHPRPS 21 1 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 PNS(0.022)S(0.062)PS(0.879)PS(0.037)PGQASETPHPRPS;PNS(0.001)S(0.002)PS(0.994)PS(0.003)PGQASETPHPRPS 142.01 7.7161e-06 12517400.0 26696.2 20353.3 29042.2 33977.0 41275.0 25584.7 30751.6 32283.1 29714.0 29863.8 True False 25212.53207735593 21914.33266382557 27173.656470756523 29349.273986405766 36089.665496818285 29108.760190217305 32181.61033313939 32377.038476245074 35657.63027852825 29001.554498529185 0.8693510576694978 0.7556261394518338 0.9369724120179364 1.0119896844803342 1.2444045197180231 1.0036965498416148 1.1096512200672375 1.1163897603449868 1.2295075520981689 1.0 14.8238426110729 -5.713169526376503 2.1678883778311913 1.1169005610889828 0.8156355262174011 0.6791049219206609 0.08232230079437322 0.16534092565051425 1.5802310126465857 0.02364273839149412 0.04740389109258271 1.935666231258016e-06 5.713169526376503 -0.30126503487158174 PNSSPSPS(ph)PGQASETPHPRPS ddPTM_A459_Selumetinib_30min_R2 1 PNSSPSPSPGQASETPHPRPS 21 1 O00204-2;O00204 O00204-2 SULT2B1 Sulfotransferase family cytosolic 2B member 1 1 PNS(0.002)S(0.006)PS(0.387)PS(0.606)PGQASETPHPRPS 109.42 6.4268e-05 3126200.0 5041.5 3074.8 5944.6 7134.8 6752.3 5367.3 4723.6 5650.6 4814.9 5265.5 True False 4761.313612723532 3310.627272959711 5562.130907991102 6163.0279317834975 5904.0157076721 6106.596855501666 4943.2567596358285 5667.042310492816 5778.0145395465315 5113.471333588004 0.9311313786876417 0.6474324498924531 1.0877407039433393 1.2052532476913376 1.154600333611216 1.1942174810661956 0.9667125201555125 1.1082573736687762 1.129959309949281 1.0 12.320087297053075 -5.335351555888816 7.396612252764421 1.114207356023137 0.7903596423196375 0.6345302883715288 0.09599159856129931 0.14367727291477497 12.638049506352603 0.024447319031771865 0.051358017521972325 4.620068812633303e-06 5.335351555888816 -0.3238477137034994 PQQAAGMLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 PQQAAGMLSPK 11 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 PQQAAGMLS(1)PK 91.62 0.026161 4934500.0 48266.0 40332.0 41078.0 44900.0 39874.0 29558.0 38646.0 33467.0 30901.0 37037.0 True False 45583.56894410669 43425.33471217998 38435.086202344704 38784.542543179756 34864.671641917186 33629.34619919108 40443.11557559622 33564.383429239904 37082.06344607931 35967.64557631736 1.267349258304549 1.2073443789930216 1.0686016720441667 1.0783175245898542 0.9693342748259726 0.9349888117595911 1.1244304409579065 0.9331826671284855 1.0309838982203419 1.0 15.134412104034077 -5.20192103628785 1.1624238129371398 1.0009772194806974 1.3117611717319426 0.7391932499002782 0.054435213682309705 0.42272837817540865 0.7719476668415491 0.017337982697161594 0.13399027980450792 6.2817256318475164e-06 5.20192103628785 0.3107839522512452 PQQTSASS(ph)PSSVNSR ddPTM_A459_Selumetinib_30min_R1 1 PQQTSASSPSSVNSR 15 0 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 PQQT(0.014)S(0.008)AS(0.038)S(0.814)PS(0.12)S(0.006)VNSR 130.47 0.00095342 0.0 563.46 689.67 295.78 563.38 466.17 291.9 707.57 326.97 58.178 497.98 True False 576.5875216976963 608.9231157811153 255.6147006032422 464.9962589523738 424.0050058089982 288.96375102399435 654.1974252321252 318.2976934517574 98.72381684699926 561.9005837359667 1.0261379653035398 1.083684789456001 0.4549109006146785 0.8275418684577704 0.7545907907585219 0.5142613469143084 1.164258312177743 0.566466208907381 0.17569623471576407 1.0 9.134171088835599 -5.239611241394021 24.45031525515637 0.6857248376522248 1.054911518553611 0.23798375668151972 0.26670212227925494 886.8001233103583 993324.7788428271 0.067102646533792 0.17716641833120503 5.759552728820672e-06 5.239611241394021 0.3691866809013863 PQQTSASS(ph)PSSVNSR ddPTM_A459_Selumetinib_30min_R2 4 PQQTSASSPSSVNSR 15 0 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 PQQT(0.001)S(0.006)AS(0.013)S(0.438)PS(0.438)S(0.104)VNSR;PQQT(0.303)S(0.03)AS(0.014)S(0.437)PS(0.17)S(0.045)VNSR;PQQTS(0.001)AS(0.02)S(0.693)PS(0.281)S(0.005)VNSR;PQQTS(0.008)AS(0.028)S(0.953)PS(0.01)S(0.001)VNSR 215.37 1.2098e-07 11903700.0 32774.3 19958.0 28496.100000000002 28536.100000000002 26901.0 24564.699999999997 33127.3 45138.2 29256.799999999996 34309.200000000004 True False 30952.835611918064 21488.714424915393 26662.691950207805 24649.433952481788 23521.45588200867 27948.26444885544 34667.785090499645 45269.54468896874 35108.97750329288 33318.604249992924 0.9289955659509548 0.6449464168331708 0.8002343600636712 0.739809920233589 0.7059556188345935 0.838818584330746 1.0404933180989118 1.3586867069612723 1.0537349415919888 1.0 15.024040345565345 -7.293289939403182 2.918487415282576 1.1596406316445589 0.7603558705232282 0.6844799637757987 0.11310127046716248 0.13512467904411368 2.3088600372482437 0.048628791212201754 0.03224992648085594 5.08990950079145e-08 7.293289939403182 -0.3992847611213307 PQSETNVASGCPLFFPLS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 PQSETNVASGCPLFFPLSK 19 0 Q13077;Q13077-2 Q13077 TRAF1 TNF receptor-associated factor 1 1 PQS(0.001)ET(0.001)NVAS(0.006)GCPLFFPLS(0.992)K 44.99800000000001 0.047252 2631800.0 19303.0 25235.0 20231.0 19150.0 16166.0 13015.0 10754.0 9892.1 9029.5 19734.0 True False 18230.216536031403 27170.443356686057 18929.359485847326 16541.73696440741 14135.082554126326 14807.698111593192 11254.082308646735 9920.884373274688 10835.65230530965 19164.22814491041 0.9512627588329428 1.4177687278212623 0.9877444237624848 0.8631569630316954 0.737576407838804 0.7726738587969579 0.587244225206929 0.517677221240421 0.5654103167305153 1.0 14.226128273125692 -5.888437399705482 1.359302353639369 0.6560632307195604 1.1932248252930888 0.5586216436169692 0.1696873787295709 0.2884764350212862 1.0803331382822883 0.05769413836497604 0.11946192028261791 1.2928930482187843e-06 5.888437399705482 0.5371615945735284 PQSPVIQAAAVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 PQSPVIQAAAVSPK 14 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 PQSPVIQAAAVS(1)PK;PQSPVIQAAAVS(1)PK;PQSPVIQAAAVS(1)PK 131.48 0.00088585 16912600.0 161996.0 100808.0 116618.0 121363.0 103787.0 98690.0 131193.0 118582.0 80320.0 110510.0 True False 152992.91084136878 108539.64945119082 109114.92484407786 104833.15003714737 90748.34919244767 112283.65168137781 137293.7344539977 118927.05398769304 96386.2443283097 107319.28916053758 1.4255863231865857 1.0113713042659809 1.0167317142853436 0.9768341819738368 0.8455921568460852 1.0462578774018352 1.2793015638467538 1.1081610297454687 0.8981260040226946 1.0 16.71154987835247 -4.760200094318741 24.988107965047206 1.0256251659936957 1.4255868048623521 0.5442920799320871 0.1111651924032681 26.800455074259265 540166.565360094 0.030202610223002656 0.18209689417484673 1.737000348900939e-05 4.760200094318741 0.39996163886865643 PQTS(ph)PSPK ddPTM_A459_Selumetinib_30min_R1 1 PQTSPSPK 8 0 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 PQT(0.005)S(0.945)PS(0.05)PK 87.149 0.032876 72411000.0 2122.9 4640.2 2014.6 1581.9 1537.2 1893.7 1604.0 2474.1 2368.5 2671.0 True False 2172.3594395556734 4096.9232268295455 1741.028385405679 1305.6508609406808 1398.1605314147032 1874.6510973420293 1483.0089886121907 2408.478830990589 4019.1715116043483 3013.8488677432183 0.7207924268552804 1.359365849654345 0.5776760752802339 0.43321709821446924 0.4639119586847934 0.6220123103736702 0.49206481601802204 0.7991372284019229 1.333567702953174 1.0 11.55739135812598 -8.099695927150057 5.172106127651758 1.1567603011637628 0.6698818768429599 0.3640850795868301 0.2600379013729076 0.26750148715290906 10.779329321024761 0.1993935974949641 0.07264246238670163 7.948845812477974e-09 8.099695927150057 -0.48687842432080297 PQTS(ph)PSPK ddPTM_A459_Selumetinib_30min_R2 1 PQTSPSPK 8 0 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 PQT(0.179)S(0.756)PS(0.065)PK 90.149 0.028672000000000007 115480000.0 39930.0 26043.0 42638.0 33135.0 22987.0 35652.0 99199.0 370150.0 49815.0 96412.0 True False 37710.85045245475 28040.414358556543 39894.71750074428 28621.955838936774 20099.167553612635 40562.73938336694 103811.95005908956 371227.07521836855 59779.39194739467 93628.33505154046 0.40277177236672757 0.2994864144825482 0.42609662426212175 0.3056975842108159 0.21466971021698142 0.4332314502980107 1.1087663793438518 3.9649009566817113 0.6384754349683497 1.0 16.514657582991333 -7.527931952763505 24.999612253897272 2.08837977465789 0.37640857177681114 0.39816677062683925 0.8277435687790691 117.38601501412138 580728.0389748216 0.35925311263906906 0.20832263531115133 2.9652959691987488e-08 7.527931952763505 -1.711971202881079 PRDVT(ph)NFT(ph)VGGFAPMSPR ddPTM_A459_Selumetinib_30min_R2 1 PRDVTNFTVGGFAPMSPR 18 1 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 2 PRDVT(1)NFT(1)VGGFAPMSPR 69.765 0.046171 3330200.0 20850.0 21848.0 22594.0 24769.0 19826.0 15318.0 22863.0 21633.0 18563.0 21711.0 True False 19691.24046916307 23523.67134760755 21140.326638487197 21395.419471091744 17335.280633311184 17427.915457040694 23926.174802175046 21695.948448464052 22276.1186935559 21084.147018047523 0.933935835882184 1.1157041983947396 1.0026645431940684 1.0147633410437604 0.8221950178241786 0.8265885948396593 1.1347945345711552 1.0290171297844226 1.0565340240934613 1.0 14.363871036560143 -9.646057430591643 9.497072844211402 0.9999997738384528 0.9927740887804282 0.00044412770481372377 0.1007068182384466 0.0 0.0 0.10405112372825681 0.025236104329165586 2.2591370048459961e-10 9.646057430591643 -0.007225685058024678 PRPATS(ph)TPDLASHR ddPTM_A459_Selumetinib_30min_R1 1 PRPATSTPDLASHR 14 1 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 PRPAT(0.137)S(0.786)T(0.077)PDLASHR 132.25 0.0004526 15469000.0 1217.5 1465.3 1482.2 1774.2 1535.5 1233.6 1029.4 967.2 684.02 1022.7 True False 1245.865381157395 1293.7419948005104 1280.9253811418127 1464.3692758587483 1396.6142961145435 1221.1911040191826 951.7515292253051 941.5467140916292 1160.7319811558389 1153.97350694159 1.0796308352514512 1.1211193212133206 1.1100128152306434 1.2689799783530642 1.210265476385183 1.0582488217218622 0.8247602943223197 0.8159170972538514 1.0058566978995567 1.0 10.172394387464609 -7.050266182681986 4.398982498517231 0.8981874836682905 1.158363366307646 0.6924025457029016 0.0770927241662102 0.12263847905952271 5.036759566398082 0.031246173570249777 0.024674594151594377 8.907048504261014e-08 7.050266182681986 0.26017588263935554 PRPATS(ph)TPDLASHR ddPTM_A459_Selumetinib_30min_R2 2 PRPATSTPDLASHR 14 1 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 PRPAT(0.051)S(0.878)T(0.071)PDLASHR;PRPAT(0.207)S(0.671)T(0.122)PDLASHR 93.427 0.0079469 37844000.0 70676.0 66931.0 77033.0 79229.0 81552.0 57948.0 61010.0 71068.0 54186.0 83318.0 True False 66748.11085844456 72064.39248291467 72076.78064718879 68437.87352235151 71306.7086758698 65929.8110004305 63847.08588902156 71274.79611405925 65024.71408333885 80912.39285383833 0.8249429846799811 0.890647154794855 0.8908002606892326 0.8458268394803127 0.8812829056320158 0.8148295789438258 0.7890890831069122 0.8808884968068041 0.8036434443460436 1.0 16.30407306785969 -11.103598126887771 7.003893256064874 1.000174966013266 0.848800487202762 0.619554949908975 0.03596738570266173 0.00010073332664285708 6.030261945809163e-06 0.03569962871254325 0.008648492725643967 7.877744172496472e-12 11.103598126887771 -0.15137447881050392 PRPVS(ph)PSSLLDTAISEEAR ddPTM_A459_Selumetinib_30min_R1 2 PRPVSPSSLLDTAISEEAR 19 1 P57059;A0A0B4J2F2 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 1 PRPVS(0.985)PS(0.014)S(0.001)LLDTAISEEAR;PRPVS(0.674)PS(0.265)S(0.061)LLDTAISEEAR 123.64 0.00022622 10673900.0 1411.3200000000002 1644.86 1479.17 1514.21 1408.58 1129.57 1505.4099999999999 1419.3400000000001 689.97 1391.15 True False 1444.2010100493255 1452.2790265253313 1278.3068384992143 1249.7816487420112 1281.1741877049978 1118.2075513675004 1391.8557116874551 1381.6944925339246 1170.8286965850336 1569.717653448512 0.9200387132530242 0.9251848721550785 0.8143546297583534 0.7961824510263782 0.8161812953370224 0.7123622193525764 0.886691761814418 0.8802184835587984 0.745884901028437 1.0 10.61628936823647 -5.259208504061356 24.236688138333967 0.8231165496037938 0.9226118084422154 0.18074492032693124 0.07595064174443708 183.04090945891656 1988541.6832380372 0.018681385103488313 0.044666488197622374 5.505433180116605e-06 5.259208504061356 0.09949525883842159 PRPVS(ph)PSSLLDTAISEEAR ddPTM_A459_Selumetinib_30min_R2 3 PRPVSPSSLLDTAISEEAR 19 1 P57059;A0A0B4J2F2 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 1 PRPVS(0.758)PS(0.152)S(0.09)LLDTAISEEAR;PRPVS(0.97)PS(0.029)S(0.001)LLDTAISEEAR;PRPVS(0.877)PS(0.087)S(0.035)LLDTAISEEAR 159.53 1.144e-06 9472400.0 22836.899999999998 16537.9 20122.199999999997 20485.6 22594.699999999997 15462.099999999999 19281.1 19746.0 17264.6 19738.6 True False 21567.716521353952 17806.30375227019 18827.559559394835 17695.425940368903 19756.151786819133 17591.86392403113 20177.70935477483 19803.457590873728 20718.00241322873 19168.69533095816 1.1251530763557644 0.9289262229293375 0.9822034955601607 0.9231419058442715 1.0306466582998066 0.9177392420453162 1.0526386384881956 1.0331145259996075 1.0808248582139224 1.0 14.226464526487169 -7.308863487632864 24.907946881533064 1.044404084698159 0.9812885865702743 0.17312364343666142 0.060653839968854525 632.5098216137674 332202.5703221506 0.024080927008704588 0.016235401641646562 4.910622081383235e-08 7.308863487632864 -0.06311549812788475 PS(ph)APSPPPR ddPTM_A459_Selumetinib_30min_R2 1 PSAPSPPPR 9 0 Q8IV50 Q8IV50 LYSMD2 LysM and putative peptidoglycan-binding domain-containing protein 2 1 PS(0.795)APS(0.205)PPPR 102.06 0.016467 23240000.0 91316.0 56001.0 74442.0 86976.0 94613.0 76685.0 100850.0 108500.0 91220.0 75494.0 True False 86241.02228691109 60296.096628404026 69652.48276632122 75129.71875803122 82726.86908904818 87247.66267287922 105539.72483048384 108815.71703685814 109466.54889975575 73314.29206303168 1.1763193759378554 0.8224330472503872 0.9500532680099777 1.0247622481771868 1.1283866591513163 1.1900498554615841 1.4395518508143879 1.4842360742337148 1.4931133592020818 1.0 16.161806847738852 -6.786986528559324 1.5613989328680937 1.3923302811543725 0.9779230774991352 0.49556593008746386 0.15835916775197575 0.27544032868214774 1.3940468946333697 0.0681164803334616 0.0605789831422171 1.6331026045445124e-07 6.786986528559324 -0.4144072036552373 PS(ph)GLPAPAPGPTSSPGPAR ddPTM_A459_Selumetinib_30min_R1 1 PSGLPAPAPGPTSSPGPAR 19 0 Q8N6N2-2;Q8N6N2 Q8N6N2-2 TTC9B Tetratricopeptide repeat protein 9B 1 PS(0.999)GLPAPAPGPTSSPGPAR 60.08 0.040489 15152000.0 1341.9 1471.8 1586.2 1332.1 1850.2 1476.1 1106.9 1307.8 980.86 1026.6 True False 1373.1636591171325 1299.4809717787427 1370.8027523729208 1099.473741613933 1682.8497366793401 1461.2517741915658 1023.4056418296973 1273.112895666907 1664.4477808200293 1158.3741099308077 1.1854232992130278 1.1218145853211132 1.183385178087934 0.9491525511387743 1.4527687750029743 1.2614679158176711 0.8834845608650798 1.0990515799277947 1.4368827536377264 1.0 10.177885547814077 -10.427081095244196 12.382867275385664 0.9999939054693187 1.1668064336236201 0.08273419748274147 0.172788136391762 0.0 0.0 0.1682624377492301 0.0408096355096466 3.740407376098647e-11 10.427081095244196 0.16681252815430148 PS(ph)HPLAK ddPTM_A459_Selumetinib_30min_R2 1 PSHPLAK 7 0 F8VWT9;J3KPF0;Q9Y4D8-2;Q9Y4D8-4;Q9Y4D8 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 1 PS(1)HPLAK 69.812 0.045415 5367100.0 86235.0 64428.0 59613.0 68391.0 66111.0 49910.0 86366.0 117020.0 71475.0 101840.0 True False 81442.40392605656 69369.42043132814 55777.56448172686 59076.027818944545 57805.54514016117 56784.64946212957 90382.19013098236 117360.508826296 85771.99717836066 98899.61458790279 0.8234855541693733 0.7014124445315408 0.5639816162493869 0.597333246091038 0.584487061764868 0.5741645172101142 0.9138780824130505 1.1866629543028706 0.8672632096268262 1.0 16.593677278357852 -7.396608953173575 4.321949785091986 1.0251087301764525 0.6365027779307362 0.7398814729058703 0.10301717425134689 0.11476968234968796 3.492845851188082 0.045942909548295253 0.02991001446170515 4.012278280241049e-08 7.396608953173575 -0.38860595224571637 PS(ph)MSPTPLDR ddPTM_A459_Selumetinib_30min_R1 1 PSMSPTPLDR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 PS(0.691)MS(0.088)PT(0.221)PLDR 160.91 0.00043418 55460000.0 3734.1 4716.6 2912.3 3057.3 3420.4 2998.3 3723.9 3376.8 1646.0 3864.4 True False 3821.0972647062254 4164.378279312149 2516.825656118811 2523.3999476287636 3111.0254239206665 2968.139824238585 3443.0032248709094 3287.236294607745 2793.1417809165114 4360.433382443613 0.8763113501724592 0.9550377024630535 0.5771962177549349 0.5787039329138048 0.7134670228988178 0.6806983535602651 0.7896011526591492 0.7538783433415416 0.6405651768841423 1.0 12.090255815909705 -9.656221037012175 9.616137375643747 0.9999851971178277 0.7277929553979163 0.3308561367793853 0.1153851475755541 0.0 0.0 0.12038560039835981 0.02919779683799042 2.2068812405221228e-10 9.656221037012175 -0.2721922417199114 PS(ph)PLGPPCLPVMDPETTLEEPETAR ddPTM_A459_Selumetinib_30min_R1 1 PSPLGPPCLPVMDPETTLEEPETAR 25 0 A0A0A0MR84;M0R202;A0A0B4J2G2;Q9NWS9-2;Q9NWS9;M0R034 A0A0A0MR84 ZNF446 Zinc finger protein 446 1 PS(1)PLGPPCLPVMDPETTLEEPETAR 103.85 5.8311e-07 1991800.0 362.76 215.48 248.13 346.69 327.44 210.74 376.27 239.53 139.0 264.68 True False 371.21160219191484 190.25150142606572 214.4353088805276 286.1470996773023 297.8231098142274 208.6201469366105 347.88765096328495 233.1768862969064 235.87284784167377 298.65425620152547 1.2429476375566173 0.6370292653645897 0.7180051997512176 0.9581216196839211 0.9972170281519871 0.6985339823713683 1.1648508057040308 0.7807586245801353 0.7897856566373923 1.0 8.222332471932932 PS(ph)RS(ph)MES(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 PSRSMESSPR 10 1 Q1ED39;H3BPL4 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 3 PS(1)RS(1)MES(0.998)S(0.002)PR 77.67399999999998 0.02902 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PS(ph)S(ph)AKRASS(ph)SGSAS(ph)KSDK ddPTM_A459_Selumetinib_30min_R2 1 PSSAKRASSSGSASKSDK 18 3 Q15555-5;Q15555-2;Q15555-4;Q15555-3;Q15555 Q15555-5 MAPRE2 Microtubule-associated protein RP/EB family member 2 4 PS(0.982)S(0.872)AKRAS(0.22)S(0.758)S(0.165)GS(0.165)AS(0.762)KS(0.078)DK 54.598 0.045638 0.0 262250.0 219200.0 179170.0 198530.0 164500.0 141180.0 257370.0 283910.0 180200.0 275990.0 True False 247675.19486992885 236011.93516091115 167642.39726554597 171489.8715166476 143834.0393513413 160626.26349556088 269338.21496897994 284736.13109616964 216245.03520868265 268021.45159186254 0.9240872079414131 0.880571065335118 0.6254812675249155 0.6398363657017603 0.5366512213745068 0.5993037592384926 1.00491290293854 1.0623632153509857 0.8068198792459943 1.0 18.031988948502963 -7.2698128287631985 24.676635849540745 0.9737209542583961 0.695469661942367 0.5075766810436781 0.1289845322609831 481.9649121827738 1420348.3785206699 0.058976545895187235 0.040514627319021626 5.372632949803022e-08 7.2698128287631985 -0.2782512923160291 PSADLTNSSAPSPS(ph)HK ddPTM_A459_Selumetinib_30min_R2 1 PSADLTNSSAPSPSHK 16 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 PSADLTNSSAPS(0.077)PS(0.923)HK 140.32 0.00026449 6167700.0 48595.0 32692.0 31188.0 32332.0 33837.0 36552.0 41818.0 37262.0 30574.0 29925.0 True False 45894.284441198084 35199.37127865188 29181.398034926886 27928.325824189043 29586.09355338196 41586.70621398037 43762.619860795 37370.426250943834 36689.65430893592 29060.987495512498 1.5792403629878347 1.211224198217189 1.0041433739797376 0.9610246667805643 1.0180691058055253 1.4310149034131083 1.5058889470824994 1.2859310529869108 1.2625054229351778 1.0 14.82679610628736 -6.764690366188467 24.999627459132817 1.3279900550091432 1.1387498555265636 0.09607819616652125 0.20480486048136465 167.7348886084219 1289848.5189639202 0.07403597035139041 0.06802162880297787 1.7191336207451328e-07 6.764690366188467 -0.18924019948257964 PSALAQETSLGAPEPLSGEQLVGS(ph)PQDK ddPTM_A459_Selumetinib_30min_R1 1 PSALAQETSLGAPEPLSGEQLVGSPQDK 28 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 PSALAQETSLGAPEPLS(0.002)GEQLVGS(0.998)PQDK 129.23 2.1142e-12 3853200.0 1478.1 1945.4 1093.8 1076.1 1034.8 1183.5 1661.5 1699.2 733.31 1964.7 True False 1512.5368541180653 1717.631663608077 945.2679678133285 888.1793358987716 941.2025227087787 1171.5950645320222 1536.1717173186762 1654.1316962205287 1244.373511156674 2216.888382798613 0.6822792098394372 0.7747939305089093 0.4263940282911387 0.400642333998579 0.4245601763317462 0.5284862664366502 0.6929404877747629 0.7461501936928115 0.5613153647301673 1.0 11.11432041903661 -9.195470489780671 0.5683292932636635 1.0164308149005723 0.5469209577301718 0.4911641444169602 0.12937590340508978 2.2940565399651494 1.1393477780956558 0.2501133352674743 0.06464229637578763 6.375724024746189e-10 9.195470489780671 -0.4695098571704005 PSANRENFS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 PSANRENFSPER 12 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 PSANRENFS(1)PER 78.508 0.024096 15777000.0 3286.9 1993.5 8340.4 9662.4 5344.0 4287.1 2787.7 2616.2 2272.2 1824.9 True False 3363.4783748059444 1760.1000932469924 7207.819490537837 7975.043225711631 4860.636143559829 4243.975666375358 2577.4215446098538 2546.809877384739 3855.757445078067 2059.143691031298 1.6334354855640916 0.854772836355809 3.5003965589831587 3.872990146558166 2.3605133360680797 2.0610391032253856 1.2516958169728223 1.2368296046932008 1.872505285508733 1.0 11.007828792196667 -7.053296318284107 2.9214971071721823 1.361265359609741 2.487775990758973 0.2845362554706652 0.8237769030861942 0.4088501571340071 6.915407662160076 0.37930182712910415 0.29574483530217444 8.845119031414114e-08 7.053296318284107 1.1265106311492321 PSDSVSSTPAATST(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 PSDSVSSTPAATSTPSK 17 0 H0Y5D5;A0A494C0L7;Q9BTG3;Q5SYW2;F5H2X7;Q9ULV3-5;Q9ULV3-3;Q9ULV3-4;Q9ULV3-2;Q9ULV3 H0Y5D5 CIZ1 Cip1-interacting zinc finger protein 1 PSDSVSSTPAAT(0.005)S(0.056)T(0.906)PS(0.032)K;PSDSVSSTPAATS(0.019)T(0.961)PS(0.019)K 200.97 1.1277999999999998e-07 13808200.0 8247.599999999999 11596.4 8475.7 8910.4 6997.299999999999 7882.0 8305.1 8465.1 4258.8 8431.8 True False 8439.753032964049 10238.688096979895 7324.7464936875385 7354.365908923346 6364.395450473656 7802.714236283397 7678.63962052563 8240.578049479991 7226.872549554817 9514.103662687106 0.8870781034332745 1.076158980391868 0.7698829814535341 0.7729961927749506 0.6689432526822116 0.820120792553951 0.8070796674877643 0.8661433952836048 0.7595957334265268 1.0 13.215852029200406 -5.274709899723185 24.934027652476733 0.7974846138723097 0.9816185446523316 0.36142889295280967 0.09139297223201322 622.9555158993207 1170473.483670145 0.02280682593341019 0.04792223782493922 5.3123918319234885e-06 5.274709899723185 0.18413393078002183 PSDSVSSTPAATST(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 PSDSVSSTPAATSTPSK 17 0 H0Y5D5;A0A494C0L7;Q9BTG3;Q5SYW2;F5H2X7;Q9ULV3-5;Q9ULV3-3;Q9ULV3-4;Q9ULV3-2;Q9ULV3 H0Y5D5 CIZ1 Cip1-interacting zinc finger protein 1 PSDSVSSTPAAT(0.001)S(0.105)T(0.894)PS(0.001)K;PSDSVSSTPAATS(0.333)T(0.667)PSK 231.13 4.2638999999999996e-16 16323400.0 140415.0 115452.0 124946.0 141558.0 137128.0 117778.0 122808.0 118283.0 104970.0 147213.0 True False 132611.29642578086 124306.79716330949 116907.1103909189 122277.55619882968 119900.75470012595 134000.85041776602 128518.81533943552 118627.1839471953 125966.93310685595 142962.57818469143 0.9275944663956893 0.8695058437091083 0.8177462373397336 0.8553116329565696 0.8386862927529732 0.9373141707381083 0.8989682263102712 0.8297778723180442 0.8811182248274857 1.0 17.125278031701164 -6.743426402509308 24.998733089630285 0.8981426141201225 0.859394288162968 0.1739821237855671 0.04879257170521428 533.4205783594266 740289.0201748041 0.016281660513673555 0.01625152991380364 1.805400662502492e-07 6.743426402509308 -0.038748325957154495 PSDVGNLDDFAES(ph)DEDEAHGPGAPEAR ddPTM_A459_Selumetinib_30min_R2 1 PSDVGNLDDFAESDEDEAHGPGAPEAR 27 0 Q8N3D4;E9PIH6;A0A0U1RQH4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 PSDVGNLDDFAES(1)DEDEAHGPGAPEAR 116.78 5.5298e-12 3986400.0 13035.0 7632.3 9501.9 8632.4 9086.4 6969.1 11107.0 13803.0 12450.0 6980.9 True False 12310.566883239355 8217.672868287498 8890.558098886488 7456.652228279396 7944.885198553355 7929.030265809005 11623.497508102973 13843.164444790333 14940.347882064898 6779.343278443554 1.815893719732938 1.2121635578504244 1.311418781101706 1.0999077524204297 1.1719254907501002 1.1695867785632186 1.7145462371056643 2.0419624550961726 2.2038045970575193 1.0 12.726929809524975 -7.3782033660728015 4.596410120688218 1.847128631844894 1.2801977948496672 0.26170157237377645 0.3515005402573082 0.25300304737387275 8.4401591840885 0.14794118658495886 0.09726186701831482 4.1859750353181186e-08 7.3782033660728015 -0.5669308369952268 PSELEDGHTALNTHSVS(ph)PMEK ddPTM_A459_Selumetinib_30min_R1 1 PSELEDGHTALNTHSVSPMEK 21 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 PSELEDGHTALNT(0.073)HS(0.279)VS(0.648)PMEK 55.247 0.021807 24377000.0 4007.1 4573.1 5331.7 5683.9 4391.9 4517.7 4002.6 4102.0 2409.3 3488.5 True False 4100.457633540693 4037.6793260234876 4607.684424931724 4691.313565017216 3994.653420452921 4472.256039743405 3700.680659488251 3993.2016348261595 4088.4061316902475 3936.2829558675435 1.041708047798857 1.0257594210814545 1.1705673795790947 1.191813093117252 1.0148288284251439 1.1361622347491367 0.9401459958491813 1.0144600069651424 1.0386464025905313 1.0 11.942618215795116 -7.253963879070505 24.955747241999774 0.9995181012148077 1.0975220792106433 0.3919683537440939 0.060085190471694395 637.3676070547144 2127752.766873417 0.024462744030657395 0.01857426125089864 5.572320928413563e-08 7.253963879070505 0.0980039779958356 PSEQKDSEQGS(ph)GQSK ddPTM_A459_Selumetinib_30min_R1 1 PSEQKDSEQGSGQSK 15 1 Q5JSZ5;A0A494C0D3;H0Y412;A0A494C065;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 PSEQKDS(0.05)EQGS(0.931)GQS(0.019)K 71.933 0.02609 22187000.0 2756.6 2958.3 3449.3 3331.3 3323.0 2564.6 2963.7 2914.9 1761.7 2798.4 True False 2820.823416590121 2611.9408607236433 2980.904005648669 2749.550991245773 3022.4352367233014 2538.802452470491 2740.145722911442 2837.587383070399 2989.4762305228533 3157.601898724303 0.8933435901877804 0.8271913130590937 0.9440404779503645 0.87077189570877 0.9571932541415021 0.804028669192335 0.8677932845234492 0.8986526718953417 0.9467552675752526 1.0 11.624613576525158 -8.435658045868012 2.061863296428578 0.9987678390084355 0.8808119185385098 0.43438125282035944 0.043747586639900395 0.28406111981692544 2.5797877628262467 0.040871858857875976 0.011484016482555006 3.667262133298998e-09 8.435658045868012 -0.11795592046992565 PSGGFVISGVLS(ph)PDTISSK ddPTM_A459_Selumetinib_30min_R1 2 PSGGFVISGVLSPDTISSK 19 0 Q03188;H0Y8J2;H0Y9W1 Q03188 CENPC Centromere protein C 1 PSGGFVISGVLS(0.866)PDT(0.053)IS(0.077)S(0.004)K;PSGGFVISGVLS(0.5)PDT(0.5)IS(0.001)SK 230.45 1.1297e-23 40507000.0 4454.1 7488.599999999999 5114.9 6698.200000000001 4158.6 4795.0 5216.6 4296.8 2836.35 4962.1 True False 4557.871863830104 6611.831230644308 4420.324674134568 5528.4851107863105 3782.4553642604633 4746.766653511658 4823.1076620912445 4182.834906026584 4813.0787911923135 5599.033869947067 0.8140461318325968 1.1808878789130839 0.7894798954263798 0.987399833471373 0.6755550068312451 0.8477831646974004 0.8614178399561713 0.7470636904838241 0.8596266611328458 1.0 12.450962191960157 -5.304754826925386 24.99360679054384 0.8365784780061342 0.9974676732355118 0.18917923573297935 0.12416668369249599 570.3613537419322 329105.3602919159 0.030107434761472915 0.06267421349072816 4.957299671898287e-06 5.304754826925386 0.1608891952293776 PSGGFVISGVLS(ph)PDTISSK ddPTM_A459_Selumetinib_30min_R2 2 PSGGFVISGVLSPDTISSK 19 0 Q03188;H0Y8J2;H0Y9W1 Q03188 CENPC Centromere protein C 1 PSGGFVISGVLS(1)PDTISSK;PSGGFVIS(0.001)GVLS(0.996)PDT(0.003)ISSK 155.92 3.3852e-06 11363300.0 61300.0 46197.0 54598.0 59858.0 48795.0 42062.0 44786.0 53936.0 38943.0 56549.0 True False 57893.19140334277 49740.161353232616 51085.224121807696 51705.23713919051 42664.93586716532 47855.65869918041 46868.637741775405 54092.94483041452 46732.688158333614 54916.28343805301 1.0542081105806766 0.9057452223499576 0.9302381902707082 0.9415283391767645 0.7769086543391537 0.871429304810163 0.8534561118769889 0.9850073865874911 0.8509805331427662 1.0 15.744946371259461 PSLPAPES(ph)PGLPAHPSNPQLPEAR ddPTM_A459_Selumetinib_30min_R2 2 PSLPAPESPGLPAHPSNPQLPEAR 24 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 PS(0.002)LPAPES(0.997)PGLPAHPS(0.002)NPQLPEAR;PS(0.002)LPAPES(0.998)PGLPAHPSNPQLPEAR 61.16 0.0047618 11164900.0 14898.0 12690.9 19696.2 24002.0 31251.0 24429.7 26178.0 29372.0 37313.0 33889.0 True False 14070.028801419248 13664.251222324816 18428.96793560111 20732.886194240553 27324.96999251528 27794.66942426343 27395.328870722904 29457.46765720364 44776.642612328345 32910.536515803615 0.42752353170124807 0.4151938153838134 0.5599716652067199 0.6299771559264807 0.8302802957768206 0.8445523035127808 0.8324181788275523 0.8950771022240305 1.3605564464385633 1.0 15.006261925379077 -6.3270973873537235 0.47344298855519756 1.1177529853936632 0.304566276404023 0.8057705279547118 0.11959310876936206 0.5921271983872274 0.25629426641912534 0.10528549076288747 0.22731091098958045 4.7087172502488545e-07 6.3270973873537235 -0.8131867089896402 down PSMS(ph)PTPLDR ddPTM_A459_Selumetinib_30min_R1 1 PSMSPTPLDR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 PSMS(0.609)PT(0.391)PLDR 122.7 0.0043834 32197000.0 3194.9 4961.3 3274.0 3253.0 3068.5 3366.7 4063.2 3467.6 1671.2 3802.2 True False 3269.3349538067832 4380.428689554203 2829.408782794693 2684.9246163727366 2790.9547167876744 3332.834054719019 3756.709552698914 3375.627983647779 2835.9043403813325 4290.249406564306 0.76203843739353 1.0210195898755718 0.6594975057779973 0.6258201707958194 0.6505343751152014 0.7768392321480445 0.8756389656393757 0.7868139270604855 0.6610115337449265 1.0 12.066845803518513 -9.254545109919553 11.424203877654453 0.9999999985188962 0.7604060288907363 0.2849819862823233 0.11507175122791871 4451690.694091817 318197.26382443815 0.11881948564532259 0.029704871421878807 5.56486829287406e-10 9.254545109919553 -0.23959396962815993 PSMS(ph)PTPLDR ddPTM_A459_Selumetinib_30min_R2 2 PSMSPTPLDR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 PS(0.031)MS(0.946)PT(0.023)PLDR;PS(0.007)MS(0.967)PT(0.027)PLDR 110.08 0.0096796 27389000.0 93634.0 68823.0 90379.0 102761.0 113085.0 85422.0 82447.0 94514.0 89162.0 89834.0 True False 88430.19712660034 74101.50279917594 84564.11353721494 88764.77452738736 98878.25130727305 97188.10511628998 86280.94886563119 94789.02009236503 106996.89139443122 87240.25900323725 1.0136397821024228 0.8493957221794382 0.9693244208969737 1.017474908277078 1.1334016248576697 1.11402815886509 0.9890038137372968 1.0865284121731877 1.2264623307739246 1.0 16.41270643267955 -5.881839141192174 2.5515443557224673 1.0913479700296258 0.9300877071679277 0.4459798740419231 0.07363365562494768 0.2463196765090425 3.252381522191951 0.02207106571047162 0.036502510530854494 1.3126860161951844e-06 5.881839141192174 -0.16126026286169814 PSMSPT(ph)PLDR ddPTM_A459_Selumetinib_30min_R1 2 PSMSPTPLDR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 PS(0.109)MS(0.208)PT(0.683)PLDR;PS(0.007)MS(0.285)PT(0.708)PLDR 155.26 0.0012355 93271000.0 7361.2 9596.3 6038.5 6266.0 6253.5 6295.4 7974.299999999999 7072.9 3800.3 7666.3 True False 7532.701637598206 8472.760734801166 5218.504867106222 5171.76072738751 5687.872029145096 6232.073991765857 7372.792130854234 6885.303715982922 6448.831537069875 8650.344281085667 0.8707979003874756 0.9794709273395287 0.6032713493862548 0.5978676176734119 0.6575312894287759 0.7204423071799052 0.852311987971987 0.7959571887835634 0.7454999856098803 1.0 13.07854183738032 -9.74094327521344 10.712638948670344 0.9999999939524565 0.755185419143022 0.28264965358847083 0.11551196402525708 0.0 0.0 0.12367345358847712 0.029995218366483223 1.8157528093836937e-10 9.74094327521344 -0.24481457480943458 PSMSPT(ph)PLDR ddPTM_A459_Selumetinib_30min_R2 4 PSMSPTPLDR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 PS(0.022)MS(0.4)PT(0.577)PLDR;PS(0.001)MS(0.233)PT(0.766)PLDR;PSMS(0.266)PT(0.734)PLDR;PS(0.027)MS(0.459)PT(0.514)PLDR 152.7 0.0014589 282853500.0 203908.0 160198.0 193955.0 179866.0 176010.0 161485.0 183717.0 209070.0 170043.0 170791.0 True False 192575.60966839828 172484.6714822428 181476.14646223665 155367.9405138432 153898.05025063566 183728.09293512334 192260.2045283291 209678.35908659818 204056.35139839063 165859.82006169023 1.1610745121800525 1.0399424732167712 1.094153764273578 0.9367424880604317 0.9278802436502976 1.1077311724249257 1.1591728753643857 1.2641901999448089 1.2302940599024736 1.0 17.339604906730912 -7.097615858392008 3.413647361309701 1.1852365341264264 1.029853888988838 0.2970707236539195 0.09204351518858982 0.27855292154423733 6.0877616699990424 0.03789149536916829 0.029083629653060137 7.987008407803814e-08 7.097615858392008 -0.15538264513758837 PSPAGGPGALS(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 PSPAGGPGALSAR 13 0 A0A3F2YP58 A0A3F2YP58 1 PSPAGGPGALS(1)AR 69.431 0.042271 1401400.0 0.0 0.0 589.74 789.13 633.6 757.34 532.5 1269.7 0.0 1192.7 True False 0.0 0.0 551.7967704603628 681.6491326748203 554.001503544132 861.656710551978 557.2623051287325 1273.3946167898496 0.0 1158.2636519932412 0.0 0.0 0.47639997120757677 0.5885094740750769 0.4783034524054673 0.7439210486050943 0.48111870226588466 1.099399618211692 0.0 1.0 10.177747971606442 -5.3616991226749695 2.7860572303186992 0.6228613975713849 5.732749858458491e-22 0.427304761799266 0.28579767343869317 0.2479395459492898 3.670364558494368 0.07252887727501962 0.19179655647621197 4.348113552610147e-06 5.3616991226749695 -0.6228613975713849 PSPGTPT(ph)SPSNLTSGLK ddPTM_A459_Selumetinib_30min_R2 1 PSPGTPTSPSNLTSGLK 17 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 PSPGT(0.009)PT(0.469)S(0.469)PS(0.006)NLT(0.009)S(0.039)GLK 79.317 0.041671 2853300.0 17879.0 14324.0 16524.0 15803.0 20480.0 14879.0 15362.0 18008.0 13290.0 15966.0 True False 16885.35675530774 15422.604741080682 15460.863829970882 13650.604138304448 17907.11930647699 16928.44719188592 16076.363439225517 18060.400298615117 15948.371353625918 15505.020095350124 1.0890251448543153 0.9946846019055365 0.9971521310448037 0.8803989968641314 1.1549239663254125 1.0918042729246558 1.0368489263710619 1.164809860777371 1.0285940460282765 1.0 13.920447775312509 -6.2779335667090415 24.982160147348537 1.0862203087542606 0.9911156553640975 0.2902188553936603 0.06783331589382398 970.3766256680371 1469731.7611149093 0.020591476206395617 0.023411258908567323 5.273105170500218e-07 6.2779335667090415 -0.09510465339016305 PSPGTPTS(ph)PSNLTSGLK ddPTM_A459_Selumetinib_30min_R1 1 PSPGTPTSPSNLTSGLK 17 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 PSPGTPTS(0.996)PS(0.004)NLTSGLK 229.02 1.4171e-51 0.0 1731.8 2171.6 1308.6 1381.4 1397.2 1316.7 1078.0 1315.3 823.9 1748.9 True False 1772.1475705037983 1917.3480624505494 1130.8993076252711 1140.1644220895473 1270.8235066956952 1303.4551934679466 996.6855920972209 1280.4139713034726 1398.098124724857 1973.388350728607 0.8980227180572403 0.9716019970132251 0.5730748877724573 0.5777699162299099 0.6439804442072877 0.660516310936309 0.5050630767781863 0.6488403414516575 0.7084759186952008 1.0 10.94645918220235 -5.257546002972315 24.991222895604814 0.6424761684361576 0.9348123845608275 0.40871442599400887 0.12772636241521257 267.34448449552343 1716041.7163631548 0.030545719918224724 0.07471707594463044 5.5265486445826945e-06 5.257546002972315 0.29233621612466987 PSPGTPTS(ph)PSNLTSGLK ddPTM_A459_Selumetinib_30min_R2 2 PSPGTPTSPSNLTSGLK 17 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 PSPGT(0.001)PT(0.191)S(0.77)PS(0.018)NLT(0.018)S(0.003)GLK;PSPGTPT(0.395)S(0.602)PS(0.003)NLTSGLK 265.27 6.664e-41 18597900.0 161996.0 106485.0 127304.0 132362.0 132981.0 125432.0 149105.0 163362.0 125836.0 127996.0 True False 152992.91084136878 114652.05709675918 119113.39923811489 114334.06726281418 116274.73791477617 142709.1194416719 156038.67794595243 163837.35637396507 151006.71615160824 124300.4229064534 1.2308317804880593 0.9223786566120098 0.9582702653212838 0.9198204204732292 0.9354331642321343 1.1480984223929198 1.255335052748652 1.3180756150545567 1.2148527947105505 1.0 16.923471679306736 -6.912105973096167 4.351617844685109 1.2214005480714507 0.9841173840473437 0.4124072992780513 0.11486738534788987 0.18592091454381082 6.474943387733458 0.04115961032984788 0.03592227791529083 1.2243174145845005e-07 6.912105973096167 -0.23728316402410699 PSQCSEFIQQSSMKS(ph)PLYLVSR ddPTM_A459_Selumetinib_30min_R1 1 PSQCSEFIQQSSMKSPLYLVSR 22 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 PSQCSEFIQQS(0.005)S(0.068)MKS(0.926)PLYLVSR 110.27 2.6806e-05 23558000.0 1020.8 2068.2 1390.8 1607.8 1121.6 1118.5 1137.7 1189.6 563.67 1473.8 True False 1044.582653868968 1826.0541825199055 1201.936999117551 1327.0279121438946 1020.1514780345626 1107.2489055167441 1051.8823730324757 1158.0479436346163 956.5068211720592 1662.9765860276873 0.6281403253933585 1.0980636756178015 0.7227624304612668 0.7979835214118887 0.6134490927929264 0.6658235087732673 0.6325298755679309 0.6963705643029033 0.5751775636582138 1.0 10.699552140924347 -5.791945527874229 2.0824098002427296 0.6805653707335295 0.8599296372003336 0.09579115920715175 0.1574094455297425 0.5204521058470365 4.608975968726904 0.044626577462857024 0.08420835559765368 1.61456105319957e-06 5.791945527874229 0.17936426646680403 PSQVNGAPGS(ph)PTEPAGQK ddPTM_A459_Selumetinib_30min_R2 2 PSQVNGAPGSPTEPAGQK 18 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 PSQVNGAPGS(0.975)PT(0.025)EPAGQK;PSQVNGAPGS(0.973)PT(0.027)EPAGQK 250.39 1.4155e-79 3656000.0 38633.0 22567.0 27272.0 34060.0 31319.0 30489.0 44128.0 43807.0 32255.0 28604.0 True False 36485.93252015237 24297.816335658164 25517.349211508496 29420.96924322277 27384.427224587565 34688.58299841452 46180.03943797317 43934.471117360765 38706.901280000275 27778.12819788268 1.3134770010505394 0.8747103535043159 0.91861298319782 1.0591415315545023 0.9858269437562347 1.2487732345140004 1.6624604476227138 1.5816210078802055 1.3934308677771388 1.0 14.761661767543579 -6.966577146208987 4.164160868165683 1.4596051779329273 1.0197047666178425 0.43949205000025626 0.19846611897230979 0.16754527244452053 6.504422005987069 0.07155768229848251 0.060640856744777184 1.0799977576721754e-07 6.966577146208987 -0.43990041131508484 PSS(ph)PGGLPEEDSVLFNK ddPTM_A459_Selumetinib_30min_R1 2 PSSPGGLPEEDSVLFNK 17 0 A0A0U1RQY6;A0A0C4DG54;Q5R372-2;Q5R372-4;Q5R372;Q5R372-3 A0A0U1RQY6 RABGAP1L Rab GTPase-activating protein 1-like 1 PS(0.009)S(0.991)PGGLPEEDSVLFNK;PS(0.004)S(0.996)PGGLPEEDSVLFNK 224.06 2.1515e-12 10227600.0 3769.3999999999996 5634.5 2877.5 3176.9 3246.1 3473.6000000000004 3721.5 3988.5 2389.3 4226.3 True False 3857.2196860243807 4974.810120592017 2486.751304976096 2622.1140527988155 2952.4908281455014 3438.6587377764563 3440.784258803162 3882.712023526118 4054.4675924324565 4768.786772648131 0.8088471701330541 1.0432024659029744 0.5214641424605342 0.5498492966467323 0.6191282959179089 0.721076219532238 0.7215219347902355 0.8141928353340967 0.8502094527872948 1.0 12.219406561434955 -8.380077877788342 1.1504111940643775 0.9939991108137574 0.7060429392870733 0.2989511771322466 0.13882870059385757 0.6522190632238397 1.8388657002747146 0.14449368087440878 0.04659156484913411 4.167946370567037e-09 8.380077877788342 -0.28795617152668407 PSS(ph)PGGLPEEDSVLFNK ddPTM_A459_Selumetinib_30min_R2 2 PSSPGGLPEEDSVLFNK 17 0 A0A0U1RQY6;A0A0C4DG54;Q5R372-2;Q5R372-4;Q5R372;Q5R372-3 A0A0U1RQY6 RABGAP1L Rab GTPase-activating protein 1-like 1 PSS(1)PGGLPEEDSVLFNK;PS(0.019)S(0.981)PGGLPEEDSVLFNK 242.93 7.677800000000002e-23 7390100.0 102901.0 60684.0 73964.0 89121.0 76925.0 68400.0 107112.0 114423.0 87242.0 66599.0 True False 97182.1743653405 65338.26767018566 69205.23676591413 76982.56605769994 67260.9937817746 77821.47912662108 112092.92023840144 114755.95198625259 104692.83774514897 64676.11382501709 1.502597614758818 1.0102379967813162 1.070027753262212 1.1902781646092446 1.0399665317515978 1.2032491521857531 1.7331424788705108 1.7743173669452035 1.6187249287797063 1.0 15.980945374164788 -7.184425308703447 6.098289310256768 1.5950293317048867 1.1494267924370154 0.34239732716982874 0.23905920078905604 0.2112833441404993 13.319503927187743 0.08799521954092618 0.06771548340824425 6.539953964667483e-08 7.184425308703447 -0.4456025392678713 PSS(ph)PLVPSCSPK ddPTM_A459_Selumetinib_30min_R2 1 PSSPLVPSCSPK 12 0 Q5T7B8;Q5T7B8-2 Q5T7B8 KIF24 Kinesin-like protein KIF24 1 PS(0.036)S(0.964)PLVPSCSPK 119.21 0.003634000000000001 0.0 26057.0 19754.0 20896.0 22246.0 17420.0 14663.0 22987.0 26413.0 14128.0 16048.0 True False 24608.856254435592 21269.068280878786 19551.574109844583 19216.05642350951 15231.543863224082 16682.695152538698 24055.941047876375 26489.85745709246 16953.99476930224 15584.652542288553 1.5790442672789846 1.364744464027396 1.2545402636851795 1.2330115394852235 0.9773425375954761 1.070456662878472 1.5435660809633835 1.699740009295229 1.0878647902670922 1.0 13.927838370181314 PSS(ph)SPVIFAGGQDR ddPTM_A459_Selumetinib_30min_R1 2 PSSSPVIFAGGQDR 14 0 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 PS(0.003)S(0.499)S(0.499)PVIFAGGQDR;PS(0.019)S(0.581)S(0.4)PVIFAGGQDR 144.88 0.00052621 90338000.0 4706.5 6475.799999999999 3933.8999999999996 4065.5 4635.7 3968.0 5715.1 6045.299999999999 2195.8999999999996 5285.6 True False 4816.152292745194 5717.610325482258 3399.6979873659284 3355.5367438866765 4216.401753499307 3928.0855226557373 5284.005405746596 5884.959006098139 3726.281917809577 5964.0582461039085 0.8075293858659752 0.9586778145933358 0.5700309834476921 0.5626264207058542 0.7069685739997126 0.6586262844132694 0.8859748157554355 0.9867373461589779 0.6247896589949997 1.0 12.54207863198078 -7.269812791517661 23.976586737036452 0.8732702530853295 0.7087128265841077 0.23753962464597778 0.14358691933128073 583.7987258522145 1671650.0435218823 0.0618619557714414 0.04253882663476849 5.3726334105655185e-08 7.269812791517661 -0.16455742650122174 PSS(ph)SPVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 2 PSSSPVIFAGGQDR 14 0 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 PS(0.011)S(0.495)S(0.495)PVIFAGGQDR;PS(0.001)S(0.5)S(0.5)PVIFAGGQDR 220.46 7.6899e-09 196760000.0 562250.0 349860.0 442830.0 581780.0 515330.0 460870.0 586190.0 628440.0 471430.0 366710.0 True False 531002.3958650813 376693.1370227928 414338.7999168488 502540.56037352147 450589.63829134783 524350.6591386831 613448.9965134488 630268.6563561579 565729.1728547676 356122.12947299524 1.4910682373231943 1.0577639125662857 1.1634738917517007 1.411146679138425 1.2652671681991503 1.4723899913623444 1.722580389545735 1.769810422308932 1.588581910627003 1.0 18.442012562170873 -6.882429827295815 3.505794477799013 1.586391078001851 1.2652364870494488 0.18391609743014226 0.22870283962159027 0.29901624395242854 7.136275459281745 0.08208726066118899 0.07181892447792472 1.3109018389682072e-07 6.882429827295815 -0.3211545909524023 PSS(ph)SPVIFAGGQLTK ddPTM_A459_Selumetinib_30min_R2 1 PSSSPVIFAGGQLTK 15 0 H3BRU6;F8VZX2 H3BRU6 PCBP2 1 PS(0.003)S(0.499)S(0.499)PVIFAGGQLTK 107.13 0.0043152 3589200.0 31744.0 24205.0 23522.0 33403.0 34895.0 25038.0 32965.0 30594.0 26570.0 23360.0 True False 29979.795561300354 26061.445668658038 22008.6201288172 28853.45377661099 30511.178134741953 28486.757227665803 34497.9378189083 30683.023474890637 31884.742427828463 22685.536103430975 1.3215378920124436 1.148813303323984 0.9701609002525888 1.2718876752596195 1.344961741068461 1.2557233427407275 1.5207018984087755 1.3525368470463484 1.405509761041362 1.0 14.469485133336512 -5.987569537924854 24.67391357699284 1.335641483090989 1.1426997881082963 0.19241231306159412 0.1484363428347106 265.1563111364777 526317.7921227828 0.04055235133306174 0.06010341055330562 1.0290357478971004e-06 5.987569537924854 -0.19294169498269276 PSSCLLIPSPENNS(ph)ERLLVDTRR ddPTM_A459_Selumetinib_30min_R1 2 PSSCLLIPSPENNSERLLVDTRR 23 2 Q9N2K0 Q9N2K0 HERV-H_2q24.3 provirus ancestral Env polyprotein;Surface protein;Transmembrane protein 1 PSSCLLIPS(0.022)PENNS(0.951)ERLLVDT(0.027)RR;PSSCLLIPS(0.012)PENNS(0.971)ERLLVDT(0.017)RR 64.24600000000001 0.0054465 62711000.0 134.32 370.28 442.38 558.59 382.01 226.25 297.9 295.45 253.45999999999998 288.84000000000003 True False 137.44939465877718 326.9274454614982 382.3072258194005 461.0427425329379 347.45726294934343 223.97413041856365 275.42916315933405 287.6137062431468 430.1031080140336 325.91542753985436 0.4217333180460421 1.003105155006877 1.1730258635045754 1.414608525939017 1.066096396761871 0.6872154905621186 0.8450939718883156 0.8824795696668153 1.3196770440130168 1.0 8.348353834911798 -4.763455927180556 5.401677158762267 1.0409758461326781 0.390824943230657 0.4506702899454115 0.20632543776329437 0.15883979061703454 14.185037722901882 0.056796610188434675 0.3872522053238696 1.724027038856784e-05 4.763455927180556 -0.6501509029020212 PSSIPAPAEAEAWS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 PSSIPAPAEAEAWSPR 16 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C1F0;F8WAB6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 PSSIPAPAEAEAWS(1)PR 140.68 0.00039891 4237800.0 1542.3 2100.8 1785.9 1539.6 1713.4 1571.0 1755.5 2252.8 1302.1 2185.4 True False 1578.2325892066108 1854.8373593645765 1543.3845892465004 1270.737761871339 1558.42327252534 1555.1971663538714 1623.0812216388417 2193.0484258742977 2209.5685983787303 2465.9173775986615 0.6400184383888449 0.7521895811330217 0.6258865780610484 0.5153204942773865 0.631985194103685 0.6306769158131081 0.6582058411135481 0.8893438384419486 0.896043240723026 1.0 11.26790874663902 -7.794887037660417 2.922317706838037 0.9385985341929843 0.6317790181722984 0.8424542140044241 0.058286399728346046 0.1080716458032775 1.8564449977077253 0.03966379075884918 0.017636540277523163 1.6036624577107323e-08 7.794887037660417 -0.3068195160206859 PSSIPAPAEAEAWS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 PSSIPAPAEAEAWSPR 16 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C1F0;F8WAB6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 PSSIPAPAEAEAWS(1)PR;PSSIPAPAEAEAWS(1)PR 177.66 1.1506999999999998e-06 7162000.0 24183.0 19997.6 24461.0 25200.0 25852.0 23626.7 23614.7 26049.0 23187.0 26908.0 True False 22839.005672219202 21531.35161758132 22887.205891123085 21767.716527575278 22604.24064018766 26881.063463171653 24712.830341640343 26124.798277355905 27825.047898910743 26131.09612461991 0.8740163659151289 0.8239742992371126 0.8758609199542712 0.8330196492242209 0.865032240989334 1.0287001867420764 0.9457249793037452 0.9997589903142994 1.0648251327159155 1.0 14.673480022400488 -6.728936410658631 7.529332260308267 1.0039209152599886 0.8521511251800415 0.8534724691812017 0.031763169005175965 0.07358658219869774 13.417231507784415 0.010565870796421704 0.010406481091275403 1.866652985912885e-07 6.728936410658631 -0.15176979007994706 PSSS(ph)PVIFAGGQDR ddPTM_A459_Selumetinib_30min_R2 1 PSSSPVIFAGGQDR 14 0 Q15366;Q15366-2;Q15366-6;Q15366-3;H3BSS4 Q15366 PCBP2 Poly(rC)-binding protein 2 1 PS(0.001)S(0.199)S(0.8)PVIFAGGQDR 76.311 0.042487 11396000.0 61380.0 41231.0 53743.0 56546.0 57444.0 52279.0 54262.0 71214.0 61942.0 61497.0 True False 57968.74532360811 44393.28512143937 50285.23389095408 48844.337252709214 50227.37116412426 59479.95770848872 56785.29051811318 71421.22094988757 74332.13080408561 59721.421821605065 0.9706524653208626 0.7433393875659449 0.8419965961487321 0.8178696314132141 0.8410277189005873 0.9959568257795732 0.9508362123014676 1.1959062388573265 1.2446477082565859 1.0 15.865960892486083 -7.321376715930027 1.3664571561658951 1.1601947321117192 0.8370901570638626 0.6537007266319824 0.09020874052349397 0.24390874207122212 0.8819793152211226 0.055710245000159184 0.030869991251776557 4.771152345825895e-08 7.321376715930027 -0.3231045750478566 PSSS(ph)PVIFAGGQLTK ddPTM_A459_Selumetinib_30min_R2 1 PSSSPVIFAGGQLTK 15 0 H3BRU6;F8VZX2 H3BRU6 PCBP2 1 PSS(0.044)S(0.956)PVIFAGGQLTK 174.21 2.709e-05 3516400.0 73077.0 53313.0 64420.0 81648.0 64821.0 56255.0 79603.0 86512.0 80627.0 53291.0 True False 69015.67289040917 57401.93567168625 60275.287335192756 70527.40154934402 56677.60647290747 64003.61561795428 83304.69723035215 86763.73559716738 96754.65290660644 51752.35036335363 1.3335756232489853 1.1091657725430215 1.1646869545440839 1.362786444560887 1.0951697087180308 1.236728673549789 1.6096794956261746 1.6765177810862417 1.869570217145527 1.0 15.659336764490968 -7.24519833178468 6.454951150898579 1.5961073223637678 1.2097796746450011 0.319682213837129 0.22389817291379677 0.15972454818415835 30.815368006554042 0.08374455864638831 0.062068993514592816 5.68593208779288e-08 7.24519833178468 -0.3863276477187667 PSSTTPTPLVSETGGNSPS(ph)DKVDNELK ddPTM_A459_Selumetinib_30min_R1 1 PSSTTPTPLVSETGGNSPSDKVDNELK 27 1 A0A3B3IRW6;Q2KHR3-2;Q2KHR3;H0YCQ7 A0A3B3IRW6 QSER1 Glutamine and serine-rich protein 1 1 PSSTTPTPLVS(0.004)ET(0.008)GGNS(0.17)PS(0.818)DKVDNELK 103.35 1.8539e-07 12322000.0 1708.6 2431.9 1394.5 1566.1 1085.8 1258.2 1817.0 1831.6 847.32 2309.9 True False 1748.4070556431413 2147.1720174403627 1205.1345594401957 1292.610034337947 987.5895817135599 1245.5436503541957 1679.942227124908 1783.0200181247176 1437.8401541957335 2606.3981653313585 0.6708134923126228 0.8238081372219608 0.4623754633770561 0.4959372867627897 0.3789097133545615 0.4778792691468329 0.6445455070796262 0.684093490335172 0.551657906040974 1.0 11.34784177811165 -9.76938074498582 0.7064144265322324 1.0246315285818857 0.564915822993173 0.508232148129582 0.1247478752756151 7.759506799808385 3.450706102891447 0.6815837367883711 0.05020658438702616 1.7006668838444192e-10 9.76938074498582 -0.45971570558871266 PSSTTPTPLVSETGGNSPS(ph)DKVDNELK ddPTM_A459_Selumetinib_30min_R2 3 PSSTTPTPLVSETGGNSPSDKVDNELK 27 1 A0A3B3IRW6;Q2KHR3-2;Q2KHR3;H0YCQ7 A0A3B3IRW6 QSER1 Glutamine and serine-rich protein 1 1 PSSTTPTPLVSET(0.002)GGNS(0.144)PS(0.853)DKVDNELK;PSSTTPTPLVS(0.024)ET(0.079)GGNS(0.046)PS(0.85)DKVDNELK;PSSTTPT(0.017)PLVS(0.044)ET(0.206)GGNS(0.293)PS(0.439)DKVDNELK 139.25 1.5712e-12 27197000.0 134732.0 89152.0 102826.0 105729.0 93012.0 91068.0 141270.0 130110.0 94489.0 101469.0 True False 127244.13481492944 95989.67173113806 96210.2871084839 91328.52780730189 81327.00102216983 103611.790367005 147839.33492119453 130488.59855912988 113389.44024324737 98539.32632187684 1.291303072230156 0.9741255122608574 0.9763643684168778 0.9268231397176289 0.8253253199287838 1.0514765447914578 1.5003079525658634 1.3242286448447125 1.1507024096436678 1.0 16.58841198804337 -7.02222823747311 23.924351840420588 1.2715522297018795 0.9867969527803723 0.3323331756004594 0.16312958204858588 452.4532083254903 486976.0308682748 0.061806007849500626 0.04833434807027203 9.50105347672205e-08 7.02222823747311 -0.28475527692150726 PST(ph)PAEEDEDDPEQEK ddPTM_A459_Selumetinib_30min_R2 2 PSTPAEEDEDDPEQEK 16 0 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 1 PST(1)PAEEDEDDPEQEK;PS(0.006)T(0.994)PAEEDEDDPEQEK 258.42 1.3612999999999993e-93 4600500.0 64181.0 41769.0 40567.0 49295.0 41820.0 42409.0 94253.0 79710.0 52856.0 36077.0 True False 60614.07695689954 44972.54799149669 37956.96338600999 42580.93596138186 36566.19772445647 48250.45479942801 98635.9512587764 79941.94290329919 63428.67692003398 35035.36327069691 1.7300827306562085 1.283632986591896 1.083390033456758 1.2153701856146006 1.0436939797635816 1.3771929357953603 2.815325489753781 2.28175007878858 1.8104187026679082 1.0 15.096524234711055 -7.033247624094407 22.802753736405254 2.085482954588255 1.2535894214120187 0.3401145654664224 0.4612545528572488 208.87747328300486 143256.78031951186 0.1703537742323831 0.13210459476998282 9.263015183041177e-08 7.033247624094407 -0.8318935331762363 PST(ph)PLDGVSTPKPLSK ddPTM_A459_Selumetinib_30min_R2 1 PSTPLDGVSTPKPLSK 16 1 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 PS(0.055)T(0.945)PLDGVSTPKPLSK 85.046 0.022997 9438800.0 63013.0 38790.0 53612.0 55657.0 54039.0 50012.0 75031.0 68953.0 44460.0 41726.0 True False 59510.9897210251 41765.06827049145 50162.66228833207 48076.42058631972 47250.13770521049 56900.69903626576 78520.09017110588 69153.64181421627 53353.2423161932 40521.26196283222 1.4686361391116358 1.030695152307944 1.2379343549157806 1.1864492431261742 1.1660579018627373 1.4042183357580875 1.937750365305201 1.7066013856539526 1.3166727720654654 1.0 15.306391484566324 -6.97134382344406 6.0314156533052445 1.5658771342086433 1.2119998865088455 0.18395973041435165 0.2536040641198993 0.21617403172928915 24.087332475899967 0.0887060663808543 0.07669069701079541 1.068208861862821e-07 6.97134382344406 -0.3538772476997978 PST(ph)THT(ph)FRQS(ph)DT(ph)PRK ddPTM_A459_Selumetinib_30min_R2 1 PSTTHTFRQSDTPRK 15 2 H0Y965;A5PLN7-2;A5PLN7-4;A5PLN7 H0Y965 FAM149A Protein FAM149A 4 PS(0.186)T(0.658)T(0.551)HT(0.791)FRQS(0.918)DT(0.895)PRK 63.694 0.039518 0.0 6608.2 5530.9 6941.4 6659.1 6342.8 9112.8 4260.9 3015.8 3108.6 8335.5 True False 6240.942698720547 5955.10224535347 6494.7978812248775 5752.1190924117645 5545.960758648553 10368.00548223792 4459.040292813177 3024.5754787074334 3730.406861541123 8094.83245677007 0.770978612843428 0.7356671403832393 0.8023387656149681 0.7105914944046816 0.6851236005521297 1.2808177979726676 0.5508502265644649 0.37364275231883837 0.4608380570522145 1.0 12.982785505240777 -7.461897879267183 24.9999794000162 0.5427874158053788 0.8217476236144817 0.1948641480591058 0.22282285392846796 317.23196132549293 130053.77203240457 0.0910785220693189 0.061405036381920616 3.45224906556078e-08 7.461897879267183 0.2789602078091029 PSTQPRPDS(ph)WGEDNWEGLETDSR ddPTM_A459_Selumetinib_30min_R1 1 PSTQPRPDSWGEDNWEGLETDSR 23 1 H0YDH0;E9PPN3;E9PS17;Q96KG9-3;Q96KG9-2;Q96KG9 H0YDH0 SCYL1 N-terminal kinase-like protein 1 PS(0.001)T(0.003)QPRPDS(0.996)WGEDNWEGLET(0.001)DSR 91.565 7.9528e-05 22152000.0 590.96 667.47 500.16 837.94 457.93 422.54 538.73 632.68 301.25 418.13 True False 604.7282181920117 589.3223021016154 432.241019182222 691.6095090818844 416.510312354108 418.2896312356238 498.09316236598875 615.8992711657278 511.19924757053417 471.8010584311009 1.281744089771521 1.2490906740678214 0.9161510163194005 1.4658922372529672 0.8828091944921586 0.8865805274506573 1.0557270982441584 1.305421554614147 1.0835059363165602 1.0 8.882034844875177 -5.039113495221946 21.11607102378937 1.0849975921565993 1.2735811114326967 0.1571316493039252 0.17623175411650385 141.87248869523324 76593.72835118855 0.04540171842244846 0.12025385690765085 9.138743852691299e-06 5.039113495221946 0.1885835192760974 PSTQPRPDS(ph)WGEDNWEGLETDSR ddPTM_A459_Selumetinib_30min_R2 2 PSTQPRPDSWGEDNWEGLETDSR 23 1 H0YDH0;E9PPN3;E9PS17;Q96KG9-3;Q96KG9-2;Q96KG9 H0YDH0 SCYL1 N-terminal kinase-like protein 1 PS(0.102)T(0.102)QPRPDS(0.796)WGEDNWEGLET(0.001)DSR;PS(0.001)T(0.003)QPRPDS(0.996)WGEDNWEGLETDSR 77.1 0.00043815 20936300.0 10575.1 11730.9 10252.7 12356.7 12482.6 9743.400000000001 10766.5 9338.3 9289.9 10100.4 True False 9987.378277479444 12630.622309211343 9593.05244429572 10673.696143503554 10914.42419214012 11085.464908221065 11267.163583415024 9365.47290696121 11148.139581493555 9808.775208009172 1.0182084985824158 1.2876859792747666 0.9780071661202605 1.0881782808915985 1.1127203917598347 1.1301579119857326 1.1486820061096956 0.9548055397695329 1.1365475653260715 1.0 13.25985728740153 -8.900623459896392 0.41910862999717474 0.9929221267224801 1.112251631701743 0.08724031210586691 0.09098431316644716 4.651440222075174 1.6914735744998088 0.16899776696253083 0.06190965072134661 1.2571194335299346e-09 8.900623459896392 0.11932950497926287 PSVPSADSETPLTQDRPGS(ph)PSGSEDKGNPAPELR ddPTM_A459_Selumetinib_30min_R2 1 PSVPSADSETPLTQDRPGSPSGSEDKGNPAPELR 34 2 Q96FS4;F6RY50 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 PSVPS(0.002)ADS(0.002)ET(0.005)PLT(0.029)QDRPGS(0.443)PS(0.075)GS(0.443)EDKGNPAPELR 48.41 0.0050574 6443100.0 9025.3 6303.7 7412.5 8612.8 8720.3 6580.6 10054.0 10693.0 5499.7 7959.3 True False 8523.709957138482 6787.173520409817 6935.587820119781 7439.7217820912865 7624.777953528877 7487.017917260866 10521.53092162305 10724.114859678559 6599.793674457222 7729.494328255061 1.1027513049566744 0.8780876512968508 0.897288687406993 0.962510801631031 0.9864523641160594 0.9686297187504458 1.3612185318723553 1.3874277416152183 0.8538454644221376 1.0 12.916158319254443 -7.145845642748052 9.515196779781304 1.1827155948856554 0.9587998313822527 0.23872059045239113 0.15720405260576992 0.4477374710034894 34.128786886746866 0.059350342564999714 0.04596774046196376 7.147503179994338e-08 7.145845642748052 -0.2239157635034027 PSYDTET(ph)DPSEGLMNVLK ddPTM_A459_Selumetinib_30min_R2 1 PSYDTETDPSEGLMNVLK 18 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 PS(0.006)YDT(0.143)ET(0.798)DPS(0.053)EGLMNVLK 96.247 0.030205000000000006 0.0 17768.0 7288.1 14892.0 13987.0 9529.0 10608.0 19550.0 16968.0 13221.0 12526.0 True False 16780.525690939547 7847.073835064929 13933.86493318364 12081.946471079185 8331.881829659145 12069.155710163706 20459.113737590073 17017.374070796388 15865.569425604832 12164.341833543518 1.379484884637718 0.6450882376082526 1.1454680511164699 0.9932264841294475 0.6849430855916713 0.9921749877895297 1.681892371782375 1.3989555952686643 1.304268627329682 1.0 13.570370643173904 -7.129616116971175 8.053994245750063 1.3784815212022323 0.9507522484245491 0.3426968144138103 0.250811329611151 0.28492170437791803 17.279349961877394 0.0916917726821691 0.07100088378134718 7.419657924108867e-08 7.129616116971175 -0.42772927277768324 PT(ph)HSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R2 1 PTHSGGGGGGGGGGGGGGGGR 21 0 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 PT(0.617)HS(0.383)GGGGGGGGGGGGGGGGR 115.96 0.00010419 599170.0 871.52 724.97 517.4 2130.8 1252.6 0.0 955.25 1186.1 586.77 1156.1 True False 823.0844073709833 780.5728678540393 484.11104730252595 1840.5813641649768 1095.23718961392 0.0 999.671017791965 1189.5513546305745 704.1403957236328 1122.7203890914627 0.733116112763434 0.6952513514836058 0.4311946696668459 1.6393942624079603 0.9755208868169012 0.0 0.8904006977204069 1.0595259213143828 0.6271734285447895 1.0 10.132782957281247 -10.987447962603694 2.7580275864285233 1.0069525805118276 0.7895888212398637 0.02502953320306689 0.4037491136100087 85732924.42145427 92131601.90400316 4617841.919619961 0.1130555208328027 1.0293238539385637e-11 10.987447962603694 -0.21736375927196383 PT(ph)T(ph)S(ph)EKINMISGPK ddPTM_A459_Selumetinib_30min_R1 1 PTTSEKINMISGPK 14 1 Q99909 Q99909 SSX3 Protein SSX3 3 PT(1)T(1)S(1)EKINMISGPK 113.69 0.008270200000000002 0.0 900.06 1087.4 886.57 1008.7 749.74 904.44 847.66 716.19 597.88 912.47 True False 921.0296467881101 960.0867024814553 766.1786635804194 832.5494806440759 681.9261493773483 895.3421547658155 783.7203237450183 697.1943146870183 1014.5586925725172 1029.594412710465 0.8945557934443797 0.9324902025778999 0.7441558094351068 0.8086188797900941 0.6623250291171837 0.8696066564782312 0.7611932563637662 0.6771543299770006 0.9853964629641245 1.0 10.007860414296067 -8.333019476151241 9.285404871577883 0.9945138837650248 0.7943504379555189 0.4754042318284961 0.0835919216022439 0.4684664068170907 57.48863057197694 0.08302738940087089 0.02147541357667925 4.644944442721475e-09 8.333019476151241 -0.20016344580950596 PT(ph)T(ph)VPT(ph)T(ph)GSSRR ddPTM_A459_Selumetinib_30min_R1 1 PTTVPTTGSSRR 12 1 F5GZM8 F5GZM8 ATP8B3 4 PT(0.998)T(0.988)VPT(0.986)T(0.952)GS(0.039)S(0.037)RR 41.427 0.048163 0.0 1260.8 1427.7 1168.9 1150.4 1019.5 1183.6 860.75 1228.2 1483.1 1696.7 True False 1290.1741869102611 1260.5442202802772 1010.1698003081 949.5042356825074 927.286405007344 1171.6940586228159 795.8229345061998 1195.624146244147 2516.7123786617713 1914.4879722575502 0.6739003877830045 0.658423682230739 0.5276448924967208 0.49595727392471367 0.4843521706296722 0.6120143221590276 0.41568447858555685 0.6245137935415054 1.3145616034840284 1.0 10.902742881168315 -8.191249575522846 5.943041409942509 1.1540615486199914 0.5525250056088779 0.8389985533951942 0.10451704142677302 0.071617185274502 4.597970270505326 0.07200755667913904 0.026128471031170584 6.437991878320593e-09 8.191249575522846 -0.6015365430111136 PTLLANGGHGVEGSDTTGS(ph)PTEFLEEK ddPTM_A459_Selumetinib_30min_R1 1 PTLLANGGHGVEGSDTTGSPTEFLEEK 27 0 E7EVA0;A0A0J9YW37;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 PTLLANGGHGVEGSDT(0.074)T(0.292)GS(0.552)PT(0.081)EFLEEK 106.19 1.4347000000000002e-09 7423000.0 1684.8 1938.7 1111.1 1379.0 1469.5 1494.7 2052.3 1723.5 930.63 1900.3 True False 1724.0525619498803 1711.7161027228226 960.218722835426 1138.1835370359688 1336.5839844612967 1479.6646750790142 1897.4933586837917 1677.7871812830044 1579.2111394740782 2144.222015489493 0.804045732902479 0.7982923831383496 0.44781683794820226 0.5308142201758613 0.6233421608425073 0.6900706477175262 0.8849332508371914 0.7824689650432449 0.7364960941852695 1.0 11.066238576681164 -7.098154500171471 4.167317846910076 0.8319812229241049 0.6342176171721446 0.40402190538802407 0.12012379256570066 0.27735687949274657 8.399318910674237 0.05084002896519254 0.0392802476199701 7.977108513144913e-08 7.098154500171471 -0.19776360575196028 PTLLANGGHGVEGSDTTGS(ph)PTEFLEEK ddPTM_A459_Selumetinib_30min_R2 2 PTLLANGGHGVEGSDTTGSPTEFLEEK 27 0 E7EVA0;A0A0J9YW37;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 PTLLANGGHGVEGS(0.001)DT(0.035)T(0.185)GS(0.526)PT(0.253)EFLEEK;PTLLANGGHGVEGSDT(0.065)T(0.196)GS(0.602)PT(0.137)EFLEEK 112.26 4.0743e-10 4641000.0 20956.3 16799.5 18694.4 19216.9 17325.1 17603.3 23478.4 22546.7 18464.3 18197.6 True False 19791.632740715697 18087.967631093612 17491.62265692373 16599.525068998475 15148.566049640844 20027.99478815279 24570.192121567 22612.30716419289 22157.675935647472 17672.188004956995 1.1199310880556614 1.023527342851943 0.9897825131793179 0.9393021998375277 0.8571981039015495 1.1333058918643804 1.3903310735872172 1.2795420215001225 1.2538162184236785 1.0 14.109193051497893 -6.990599271088411 8.78655738226092 1.2554396046684573 0.9863394668442347 0.5198741957603621 0.11052927900000958 0.10637812326289767 69.13575672125117 0.039082822722094346 0.033649490446471024 1.0218819519942116e-07 6.990599271088411 -0.2691001378242226 PTLLANGGHGVEGSDTTGSPT(ph)EFLEEK ddPTM_A459_Selumetinib_30min_R1 1 PTLLANGGHGVEGSDTTGSPTEFLEEK 27 0 E7EVA0;A0A0J9YW37;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 PTLLANGGHGVEGS(0.041)DT(0.167)T(0.054)GS(0.322)PT(0.416)EFLEEK 69.7 0.0009861000000000002 4803500.0 1012.9 1216.7 876.38 667.81 866.16 783.08 1055.2 1033.3 473.12 845.23 True False 1036.4985992396923 1074.2481983715159 757.3724096107553 551.1895198462582 787.8159809329685 775.2029261797514 975.605414453606 1005.8935273685692 802.8500846823933 953.7235037374015 1.0867915021260524 1.1263727843151694 0.7941215736456154 0.5779342940446426 0.8260423255227711 0.8128172611264449 1.0229436630537623 1.0547014133831518 0.841805912862823 1.0 9.897427261451755 -10.666885668944122 14.34554210653928 0.999951629761182 0.901339009845752 0.03039627643609699 0.1601488734008705 0.0 0.0 0.17243146432033532 0.04182077297486268 2.1533485441580684e-11 10.666885668944122 -0.09861261991543002 PTLLANGGHGVEGSDTTGSPT(ph)EFLEEK ddPTM_A459_Selumetinib_30min_R2 1 PTLLANGGHGVEGSDTTGSPTEFLEEK 27 0 E7EVA0;A0A0J9YW37;P27816;P27816-6;P27816-2;P27816-5;H7C456 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 PTLLANGGHGVEGS(0.002)DT(0.073)T(0.27)GS(0.27)PT(0.384)EFLEEK 73.058 0.0062022 0.0 5104.6 5103.1 6241.4 5847.0 6804.1 5828.8 7341.4 6339.9 6654.1 5095.5 True False 4820.906767332848 5494.491360947278 5839.835119122507 5050.62851336241 5949.308128574229 6631.66429142178 7682.78964670812 6358.348059373056 7985.105931088204 4948.379675301048 0.9742394649698247 1.1103617186797627 1.1801509791722327 1.0206630947442692 1.2022739803635392 1.3401688485066223 1.552586937711225 1.284935368057874 1.6136809329616382 1.0 12.272740483169489 -6.648745074134409 2.7353442340726017 1.3922817834263832 1.0829255660659092 0.3991866473798903 0.16371164178725725 0.24862966066564907 3.769324653910012 0.05524458112560798 0.054708646293715454 2.2451994433093118e-07 6.648745074134409 -0.30935621736047403 PTPVS(ph)PATSSAS(ph)TMPVRGGTR ddPTM_A459_Selumetinib_30min_R2 1 PTPVSPATSSASTMPVRGGTR 21 1 P28908-3;P28908 P28908-3 TNFRSF8 Tumor necrosis factor receptor superfamily member 8 2 PT(0.453)PVS(0.512)PAT(0.029)S(0.03)S(0.011)AS(0.478)T(0.478)MPVRGGT(0.007)R 50.938 0.018713 528180.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PTS(ph)SPAKGPPQK ddPTM_A459_Selumetinib_30min_R1 1 PTSSPAKGPPQK 12 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 PTS(0.5)S(0.5)PAKGPPQK 205.31 8.779299999999999e-05 42927000.0 3976.2 4807.6 2977.4 3518.6 2947.4 3119.8 3621.7 3538.3 1579.8 3654.9 True False 4068.837723661625 4244.723957007398 2573.085433687515 2904.1425623022183 2680.808190405733 3088.4176445517583 3348.5122531526004 3444.4527899818117 2680.8052159732097 4124.042016740802 0.9866140323364591 1.0292630239402774 0.6239231858556582 0.7041981023746551 0.6500438597675479 0.7488812267224451 0.8119491119537389 0.8352128266394181 0.6500431385254967 1.0 12.009843315970144 -2.845834132593635 10.92824364472962 0.7923248524788181 0.8769804494417508 0.0 0.1475609027918226 0.0 0.0 0.03492289593609265 0.0 0.0014261521710832573 2.845834132593635 0.08465559696293268 PTSS(ph)PAKGPPQK ddPTM_A459_Selumetinib_30min_R1 1 PTSSPAKGPPQK 12 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 PTS(0.021)S(0.979)PAKGPPQK 197.38 0.00067817 50766000.0 1992.1 3248.6 1841.5 1916.4 1657.0 1679.4 2151.6 2340.7 1168.4 2785.0 True False 2038.5120540481687 2868.252401766833 1591.43441463544 1581.7367152833433 1507.1246425671109 1662.5067607731962 1989.303079736901 2278.617032334858 1982.6894634403707 3142.4818781972494 0.6486949274684772 0.9127347469103835 0.5064259640371895 0.5033399639493672 0.4795969240184464 0.5290425928333207 0.6330356567968839 0.7251010890926869 0.6309310730465635 1.0 11.617688709718262 -9.249151067218474 0.8317699696786286 1.0040468328173033 0.6043923108085144 0.4693256793566458 0.12257830545200203 2.925567830353533 2.5723124626983664 0.16422890762444722 0.044791886153485 5.634416313100038e-10 9.249151067218474 -0.3996545220087889 PTTQQS(ph)PQDEQEK ddPTM_A459_Selumetinib_30min_R1 2 PTTQQSPQDEQEK 13 0 Q96QK1;I3L4S0;A0A1W2PP10;A0A3B3ITD4 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 1 PTT(0.006)QQS(0.994)PQDEQEK;PTT(0.001)QQS(0.999)PQDEQEK 246.96 1.0229e-22 5964700.0 2397.27 3474.1000000000004 2074.55 2673.2 2094.56 2240.55 2873.1 3087.8 1314.46 2671.39 True False 2453.1217267245897 3067.350756934727 1792.8375046874578 2206.37580217879 1905.107417824602 2218.012101256633 2656.3797538539197 3005.9015134120455 2230.5426156400476 3014.28892804214 0.8138309847815275 1.0176034315751716 0.5947795806860336 0.7319722345302476 0.6320254837222984 0.7358326139947341 0.8812624858690332 0.9972174483500683 0.7399896522490442 1.0 11.55760199458904 -7.322589373138775 5.19741588515705 0.9070558687660855 0.7524950687948699 0.25523901882147215 0.12613608311086233 0.3342066241426622 18.68962830965542 0.055803579302928855 0.03743193140774753 4.7578486949875407e-08 7.322589373138775 -0.15456079997121552 PTTQQS(ph)PQDEQEK ddPTM_A459_Selumetinib_30min_R2 2 PTTQQSPQDEQEK 13 0 Q96QK1;I3L4S0;A0A1W2PP10;A0A3B3ITD4 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 1 PTTQQS(1)PQDEQEK;PTTQQS(1)PQDEQEK 238.07 1.1533e-17 11339800.0 47552.0 36114.0 41075.0 42236.0 33741.0 34679.0 50300.0 51785.0 34442.0 43710.0 True False 44909.250205738215 38883.82767518762 38432.27921907857 36483.3839388361 29502.153931632845 39455.71746538154 52639.049667559135 51935.68577653173 41331.36238988592 42447.97872778115 1.0579832432950742 0.9160348464304878 0.905397156023488 0.8594845981431534 0.6950190519277757 0.9295075678022509 1.2400837741917776 1.2235137533778755 0.9736944756532205 1.0 15.373408237242163 -7.120175056549117 6.1312834211517755 1.1264217734232127 0.8810267952479839 0.4607928676163501 0.11409166971543432 0.20461225219230667 9.47225190974631 0.0454359846990826 0.0351431011732012 7.582718672245022e-08 7.120175056549117 -0.24539497817522882 PTVMGEPFTVNPALT(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 PTVMGEPFTVNPALTPAK 18 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 PTVMGEPFT(0.022)VNPALT(0.978)PAK;PTVMGEPFTVNPALT(1)PAK 181.34 2.6564e-09 8763500.0 62434.0 46222.0 59393.0 53755.0 62202.0 52227.0 73244.0 65560.0 54351.0 58333.0 True False 58964.168223104454 49767.07877284493 55571.71904220899 46433.47626745276 54387.62866706459 59420.7951804977 76649.9911302326 65750.76874595768 65222.718693824034 56648.77472266438 1.0408727904844466 0.8785199506342336 0.9809871319242414 0.8196730908087122 0.960084819721703 1.0489334583387604 1.3530741221763094 1.160674155228493 1.1513526817329263 1.0 15.789757131347177 -6.948085505767724 3.7190747565249076 1.1826159476484805 0.9298546480916532 0.5453051827074953 0.09798245169878438 0.155780253476788 4.468671606988314 0.03554735967890334 0.03023688278756793 1.126975550532069e-07 6.948085505767724 -0.25276129955682736 PVAPPS(ph)SPATTSWRALAAS(ph)PWRARS(ph)S(ph)CS(ph)QT ddPTM_A459_Selumetinib_30min_R2 1 PVAPPSSPATTSWRALAASPWRARSSCSQT 30 3 E9PMB8 E9PMB8 RIN1 5 PVAPPS(0.796)S(0.177)PAT(0.027)T(0.027)S(0.027)WRALAAS(0.968)PWRARS(0.949)S(0.949)CS(0.944)QT(0.137) 45.957 0.034203 0.0 3446.3 3529.5 3226.7 4103.8 3617.0 7155.2 3737.0 1444.4 3951.4 4111.8 True False 3254.768442631975 3800.2013008687713 3019.097634965326 3544.8553605501343 3162.6001236097322 8140.763851561397 3910.77790472502 1448.6029648667084 4741.790411340661 3993.0816502605953 0.8151019006635047 0.9516963672958613 0.7560821188738513 0.887749280137758 0.7920198985671469 2.0387171023738313 0.9793884140760798 0.36277819782928056 1.1875014904919872 1.0 11.963286857064226 PVPDS(ph)PVSVTR ddPTM_A459_Selumetinib_30min_R1 1 PVPDSPVSVTR 11 0 G3XAC1;A0A0C4DFT5;Q9BXS9-5;Q9BXS9-7;Q9BXS9-4;Q9BXS9-2;Q9BXS9-3;Q9BXS9 G3XAC1 SLC26A6 Solute carrier family 26 member 6 1 PVPDS(0.997)PVS(0.003)VTR 94.402 0.02225 5680900.0 1931.2 2319.8 1996.8 1603.5 2499.1 2308.8 2649.9 2656.7 1057.7 2234.0 True False 1976.19320253894 2048.196737554239 1725.6455276372762 1323.4788264228978 2273.0568462519404 2285.575568222674 2450.015909553269 2586.2356858221992 1794.8396486484764 2520.7556610027495 0.7839685666927416 0.8125328326107862 0.6845746909681913 0.5250325713426829 0.901736285438996 0.9067025430435723 0.9719370851590826 1.0259763474232968 0.7120244442630724 1.0 11.299640567974183 -6.430564758157465 9.862345780001954 0.925374818328308 0.7083157320565536 0.4999519526614835 0.10699069203388278 0.4045597121410866 40.97894324669608 0.03385796991629238 0.03837724768832143 3.710523973113422e-07 6.430564758157465 -0.2170590862717544 PVPDS(ph)PVSVTR ddPTM_A459_Selumetinib_30min_R2 2 PVPDSPVSVTR 11 0 G3XAC1;A0A0C4DFT5;Q9BXS9-5;Q9BXS9-7;Q9BXS9-4;Q9BXS9-2;Q9BXS9-3;Q9BXS9 G3XAC1 SLC26A6 Solute carrier family 26 member 6 1 PVPDS(1)PVSVTR;PVPDS(0.999)PVS(0.001)VTR 161.25 0.00060989 20700500.0 133702.0 55606.0 89971.0 98034.0 73191.0 58761.0 177500.0 102052.0 79653.0 70217.0 True False 126271.37809151277 59870.80139852919 84182.36381301812 84681.6000819171 63996.09224415811 66854.79437075122 185754.10170957752 102348.9544243818 95585.8256907725 68189.6527643242 1.8517674305796736 0.8780041981655712 1.2345328125363482 1.2418541032111141 0.9385015123238742 0.9804243262803156 2.724080475253003 1.500945528761062 1.401764370631633 1.0 16.057265217946487 PVS(ph)GHGMDSR ddPTM_A459_Selumetinib_30min_R2 1 PVSGHGMDSR 10 0 P36507;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 PVS(0.999)GHGMDS(0.001)R 89.9 0.034155 0.0 4489.4 5841.6 5390.8 8524.5 9107.4 8589.6 9502.8 9706.3 8779.8 6774.3 True False 4239.897120492117 6289.631936295508 5043.961797059254 7363.448394417276 7963.246990810972 9772.739431374639 9944.699029440966 9734.543726035536 10536.005328108708 6578.708357254816 0.6444877763606098 0.9560587876432427 0.7667100474969245 1.1192848192300653 1.2104575181584583 1.4855103617106744 1.5116491702317567 1.4797044035704292 1.6015309930086647 1.0 12.683588642254412 -6.1373175015772095 1.335292087169335 1.4525108768985062 0.7794953124360122 0.6991932660785536 0.1747788396579517 0.2195463979346497 0.7921240513112145 0.061928154468878144 0.09865707848731246 7.28924417432894e-07 6.1373175015772095 -0.673015564462494 PVS(ph)MPVDR ddPTM_A459_Selumetinib_30min_R2 2 PVSMPVDR 8 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8;Q4KWH8-3;Q4KWH8-4 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 PVS(1)MPVDR;PVS(1)MPVDR 94.309 0.022842 19651200.0 98578.0 78511.0 78957.0 89370.0 87260.0 73466.0 95665.0 99137.0 79502.0 83293.0 True False 93099.42939900045 84532.54124734628 73876.99258188148 77197.65182815102 76297.61868570223 83585.27464205197 100113.6120566013 99425.47225698619 95404.62147148004 80888.11466879607 1.150965500682081 1.0450551554263894 0.9133232105158801 0.9543757095123803 0.9432488196579922 1.0333443298103766 1.2376801272538718 1.2291728230296015 1.1794640270962324 1.0 16.30364011473783 -7.137221437454428 5.139360806608708 1.1797452437397236 0.9957890494411042 0.4264352544056961 0.08728193547451983 0.19980631490937945 7.540663523356732 0.03462444930900924 0.026668152976780886 7.290856702985763e-08 7.137221437454428 -0.1839561942986193 PVS(ph)PETQADLQR ddPTM_A459_Selumetinib_30min_R1 2 PVSPETQADLQR 12 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 PVS(0.654)PET(0.346)QADLQR;PVS(0.996)PET(0.004)QADLQR 104.9 0.0095466 9340100.0 3598.5 4580.8 2733.3999999999996 2762.3 3854.7 3148.9 4896.3 3784.3999999999996 1697.63 3603.7 True False 3682.3380485378925 4044.4778064438574 2362.2192934914515 2279.916159792934 3506.0430656025605 3117.2249249724423 4526.9681489662535 3684.02541853635 2880.7541200105065 4066.2699980105667 0.9055812944884344 0.9946407416188863 0.5809302615535057 0.5606898117705881 0.8622258402216039 0.7666054950845745 1.113297481766111 0.905996262013779 0.7084512640380307 1.0 11.989490297153758 -7.1232252490822665 18.74593098866349 0.9264125814012287 0.7731434132779442 0.18673800171129773 0.15650465652201134 5.450348749179494 807.226255979945 0.0640170275215655 0.04958749532002414 7.529649332789412e-08 7.1232252490822665 -0.1532691681232845 PVS(ph)PSSLLDTAISEEAR ddPTM_A459_Selumetinib_30min_R1 4 PVSPSSLLDTAISEEAR 17 0 P57059;A0A0B4J2F2 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 1 PVS(0.827)PS(0.163)S(0.01)LLDTAISEEAR;PVS(0.87)PS(0.13)SLLDTAISEEAR;PVS(0.62)PS(0.033)S(0.347)LLDTAISEEAR;PVS(0.99)PS(0.005)S(0.005)LLDTAISEEAR 301.04 3.348599999999999e-89 47710400.0 3296.93 3987.94 2815.0 3160.3199999999997 2610.16 2768.9400000000005 3438.3599999999997 3541.4900000000002 1750.29 3097.0 True False 3373.742054290964 3521.030130856993 2432.7384616881677 2608.4294385536696 2374.071488861176 2741.0869775963674 3179.0017369604825 3447.5581808192337 2970.1142938762805 3494.530117334608 0.9654351060119714 1.0075832837699499 0.6961561011080073 0.7464320955811947 0.6793678718304932 0.7843935766926753 0.9097079235892266 0.9865584399223317 0.8499323783598361 1.0 11.770882765165531 -7.372686874316031 4.667629181155321 0.939864000194355 0.8079268733938113 0.24809992269565617 0.10588407795104463 0.3751763427293934 12.925918092533033 0.051104929567010154 0.03367372747617926 4.239485221457263e-08 7.372686874316031 -0.1319371268005437 PVS(ph)PSSLLDTAISEEAR ddPTM_A459_Selumetinib_30min_R2 2 PVSPSSLLDTAISEEAR 17 0 P57059;A0A0B4J2F2 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 1 PVS(0.979)PS(0.021)SLLDTAISEEAR;PVS(0.958)PS(0.041)SLLDTAISEEAR 283.22 5.855199999999998e-64 68261000.0 28682.0 21793.0 23322.0 26381.0 30028.0 22193.1 26559.0 28414.0 22941.0 25009.0 True False 27087.969263143168 23464.453024460443 21821.48791107366 22787.862290236648 26255.614186273982 25249.998076096737 27794.046125660087 28496.680035809062 27529.841025096448 24286.925188814435 1.1153313584388516 0.9661351876386234 0.8984870559540301 0.9382769582018479 1.0810596229104474 1.0396539652424117 1.1444036620354432 1.1733342040734522 1.133525170892179 1.0 14.567892230756456 -6.673087272286261 1.7372508970696405 1.1214411745872181 0.9760051222087511 0.3633397216300479 0.07198973522113171 0.34734260654089544 2.16212986760164 0.029966629381239143 0.029237075726043452 2.12281783493212e-07 6.673087272286261 -0.14543605237846702 PVS(ph)SAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 3 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVS(0.656)S(0.314)AAS(0.029)VYAGAGGSGSR;PVS(0.965)S(0.032)AAS(0.003)VYAGAGGSGSR;PVS(0.789)S(0.105)AAS(0.105)VYAGAGGSGSR 196.65 2.6031e-10 392368000.0 9834.1 5570.5 4629.69 4453.5 4083.5 4815.3 4645.4 4429.8 4843.18 4379.09 True False 10063.215396172427 4918.303270344811 4001.0035270668213 3675.779827548721 3714.1481460004825 4766.862453942584 4294.993737967004 4312.307313981694 8218.522728128328 4941.188857448765 2.036598010416519 0.995368404696887 0.8097248744166844 0.7439059573704698 0.7516709547341957 0.9647197448760966 0.8692227441362351 0.872726673355332 1.6632682872946727 1.0 12.270642482827146 -4.762264659811955 5.409343376461551 0.9345121275569321 2.0923671448840913 0.6212035477189944 0.25094573663648717 0.09935369671989579 8.917903422745724 0.06255965895797395 0.4324075617070377 1.7287625272559812e-05 4.762264659811955 1.1578550173271591 PVS(ph)SAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 3 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVS(0.794)S(0.2)AAS(0.005)VYAGAGGSGSR;PVS(0.494)S(0.494)AAS(0.012)VYAGAGGSGSR;PVS(0.439)S(0.439)AAS(0.121)VYAGAGGSGSR 279.12 6.525e-67 219818000.0 257432.0 207182.0 237780.0 263458.0 247356.0 220246.1 239873.0 252187.0 209810.1 206168.0 True False 243124.96002194635 223072.19320487103 222481.4936752897 227574.56590960023 216280.9278893031 250583.00107996695 251027.56979933244 252920.82241819473 251777.982584002 200215.3941512057 1.2143170161947423 1.1141610471590588 1.1112107269197709 1.1366486921466812 1.0802412512095072 1.2515671042293726 1.253787556464078 1.2632436356376529 1.2575355838715152 1.0 17.611193378739472 -6.769791681380127 24.999467451080978 1.2247145599175822 1.1295420348246519 0.153280912438846 0.08053889570997345 256.17706718351775 766765.1866460677 0.026514966127050104 0.023763975017068246 1.6990584466860625e-07 6.769791681380127 -0.09517252509293028 PVSS(ph)AASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 2 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVS(0.058)S(0.942)AASVYAGAGGSGSR;PVS(0.322)S(0.529)AAS(0.15)VYAGAGGSGSR 230.48 3.0811999999999996e-52 15105000.0 5691.4 4420.5 3172.04 3620.5 2798.86 3611.0 4148.54 3848.51 2872.0 3431.7599999999998 True False 5823.998546463402 3902.945804965305 2741.2943907685026 2988.2476402021202 2545.7036071788684 3574.6766185256733 3835.6122877912844 3746.435013077721 4873.5742374193305 3872.2598241731434 1.5040309304934154 1.0079245665801142 0.707931418665549 0.7717063874556018 0.6574206594523809 0.9231499901453504 0.9905358787772759 0.9675061032036273 1.2585865770151416 1.0 11.91896004369761 -8.076240940960966 5.4898284325642415 1.1297011757686475 0.9175915789527573 0.09393092005489267 0.22891595790465707 0.5203165851476109 27.292771531876337 0.16767665626763997 0.06201322909873601 8.389943941415371e-09 8.076240940960966 -0.21210959681589014 PVSS(ph)AASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 1 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVS(0.336)S(0.648)AAS(0.016)VYAGAGGSGSR 118.05 0.0010057 18864000.0 26815.0 21446.0 21676.0 27273.0 23258.0 19105.0 20598.0 25129.0 17345.0 21542.0 True False 25324.72964895001 23090.839240241297 20281.389759044367 23558.370351450816 20336.122110841898 21736.54033207746 21555.84781416267 25202.1212296701 20814.48465979244 20920.02648716224 1.2105495977498288 1.1037672086319392 0.9694724703857437 1.126115703816514 0.9720887362796286 1.03903024909726 1.03039295038133 1.2046887820689716 0.9949549859588102 1.0 14.352597057753492 -4.86400892304604 3.586956714815688 1.0486771858457382 1.2161111975626515 0.35094796753507473 0.06962916391179758 0.2808652383053556 6.070360043279366 0.01712119523517258 0.10950004787263298 1.3677007244285197e-05 4.86400892304604 0.1674340117169133 PVSSAAS(ph)VYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 3 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVS(0.111)S(0.341)AAS(0.547)VYAGAGGSGSR;PVSS(0.007)AAS(0.993)VYAGAGGSGSR;PVS(0.307)S(0.184)AAS(0.509)VYAGAGGSGSR 248.7 7.433999999999998e-33 640152000.0 8926.02 4583.4 4154.97 4267.27 3636.5600000000004 4343.219999999999 3265.8500000000004 3801.66 4804.139999999999 3615.9 True False 9133.978898988524 4046.7733972351466 3590.747895616514 3522.071401078663 3307.6337900868166 4299.53115012824 3019.5043051490793 3700.8276272679727 8152.274699497107 4080.0359868486335 2.2387005723553655 0.9918474764142513 0.8800775059805198 0.8632451802953495 0.8106874058828069 1.0537973596279826 0.7400680569686114 0.9070575943930445 1.998088920238622 1.0 11.994366161814519 -4.7612199376620525 24.9999907761904 0.9996730957791914 2.2387019158051253 0.5345104762128385 0.33829404989431733 3.9914748543985374 453727.85911453806 0.08288213280162389 0.46719193800440567 1.7329261780427352e-05 4.7612199376620525 1.239028820025934 PVSSAAS(ph)VYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 4 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVSS(0.001)AAS(0.999)VYAGAGGSGSR;PVSS(0.026)AAS(0.974)VYAGAGGSGSR;PVSSAAS(0.975)VYAGAGGS(0.025)GS(0.001)R;PVSSAAS(0.997)VY(0.003)AGAGGSGSR 228.26 3.0608999999999997e-40 294541400.0 154646.6 107333.8 127767.6 133977.0 121689.4 105365.2 108947.6 102780.7 81187.8 112966.8 True False 146051.96107138958 115565.95732743695 119547.17171884474 115729.101476784 106401.68965496107 119878.29988994534 114013.87927557397 103079.77482073914 97427.62857666727 109705.15496100449 1.3313135661063953 1.0534232176101088 1.0897133481224166 1.054910332316843 0.9698877841500004 1.0927316946278136 1.0392754954505197 0.9396073945420305 0.8880861488350172 1.0 16.743271792903023 -1.5228787452803376 0.7195219219177345 0.9936314815754514 45.65369613666218 0.7215543907198549 0.060128463035178645 183.37752259894225 0.8988980101272133 0.024451705667084555 13217.128766731154 0.029999999999999995 1.5228787452803376 44.66006465508673 PVSSAASVY(ph)AGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 1 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVS(0.001)SAAS(0.082)VY(0.917)AGAGGSGSR 163.45 6.9826e-05 26734000.0 877.03 1152.1 937.86 1059.6 976.85 755.63 1051.2 1106.9 507.24 1148.3 True False 897.4630925966893 1017.2115964032405 810.5037632962225 874.5607511554111 888.4940899768751 748.0290482571461 971.9071376740252 1077.5414162820757 860.7492326561916 1295.6954903891933 0.6926496999129901 0.7850699519666434 0.6255356828113743 0.674973987053637 0.6857275467633175 0.5773185550197891 0.7501045923854296 0.8316316791057212 0.664314446597051 1.0 10.339510985813318 -9.868825215568313 0.4881091152729626 1.0482060781155247 0.6829294136790787 0.6265164132477015 0.07009986179561287 4.8033378089507 1.1172667133625267 0.48678834017926015 0.03669147369492198 1.3526168224589925e-10 9.868825215568313 -0.365276664436446 PVSSAASVYAGAGGS(ph)GSR ddPTM_A459_Selumetinib_30min_R1 3 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVSSAASVYAGAGGS(1)GSR;PVSSAASVYAGAGGS(0.988)GS(0.012)R;PVSSAAS(0.001)VYAGAGGS(0.805)GS(0.194)R 209.19 1.4069e-11 57468000.0 3294.49 3420.45 3314.69 3586.5099999999998 3140.03 2822.55 3341.92 3274.85 1591.5 3003.22 True False 3371.2452070383765 3019.982123875935 2864.573304288866 2960.1933556307968 2856.0148409173225 2794.1577096703504 3089.8362838047706 3187.990339788016 2700.659261439021 3388.7125408400525 0.9948454365511493 0.8911886409601713 0.8453279142935937 0.8735451354917738 0.8428023346616837 0.8245484608079758 0.9118024165716956 0.9407674157565817 0.796957319008692 1.0 11.726521545121095 -9.971021795183434 9.82418812225885 1.000003546093238 0.8792746335545125 0.29653855243318883 0.05533940979262988 0.0 0.0 0.053564793837810515 0.012991370753395693 1.0690012297670237e-10 9.971021795183434 -0.12072891253872542 PVSSAASVYAGAGGS(ph)GSR ddPTM_A459_Selumetinib_30min_R2 5 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVSSAASVYAGAGGS(0.966)GS(0.034)R;PVSSAAS(0.036)VY(0.023)AGAGGS(0.891)GS(0.05)R;PVSSAASVYAGAGGS(0.988)GS(0.012)R;PVS(0.064)S(0.029)AAS(0.333)VY(0.002)AGAGGS(0.554)GS(0.017)R;PVSSAAS(0.001)VYAGAGGS(0.974)GS(0.025)R 254.8 1.5606e-33 359477130.0 295481.7 184277.6 199145.6 244099.6 199801.90000000002 212184.5 143617.3 151131.9 135759.5 145244.6 True False 279060.01002096443 198411.09937412548 186332.78890933536 210852.81338470255 174700.999070351 241410.98885588496 150295.78902228104 151571.66880776716 162915.19343736433 141051.01100720838 1.9784332492781858 1.4066620150917297 1.321031218271898 1.494869209933752 1.2385660891251815 1.7115154803360304 1.0655420896954806 1.0745876100102616 1.1550090444161267 1.0 17.105857481160427 -1.5228787452804957 0.18466665173100666 0.9680356548714006 4.409296716481281 0.5680373205910305 0.19497699129854928 45.26808814042407 0.5190928317159256 0.43198585616947016 44.02412139219241 0.029999999999989074 1.5228787452804957 3.44126106160988 PVSSAASVYAGAGGSGS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVSSAASVYAGAGGS(0.455)GS(0.545)R 154.46 4.4171e-05 275830000.0 887.75 1543.9 1127.4 1167.0 1034.3 1310.6 1063.5 1024.5 686.44 1217.2 True False 908.4328477392003 1363.139470260362 974.3052723649168 963.2053573031005 940.7477476204965 1297.4165539295889 983.2793387712378 997.3269319549971 1164.8385444060334 1373.439476532027 0.6614291079160027 0.9925005750543353 0.7093907587577611 0.7013089209691431 0.6849575563357992 0.9446477810624768 0.7159247681259647 0.7261528076018868 0.8481178561630421 1.0 10.423577621118103 -8.588622020399253 4.521134877833599 0.9999466222447413 0.7723520515743619 0.31076237929406303 0.10605152071518599 0.42271215482845476 24.3143126014779 0.10008751837263083 0.02610397739296248 2.5785643831274217e-09 8.588622020399253 -0.22759457067037936 PVSSAASVYAGAGGSGS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVSSAASVYAGAGGS(0.23)GS(0.769)R;PVSSAASVYAGAGGS(0.227)GS(0.773)R 276.05 5.2428e-55 530790000.0 276874.0 211078.0 221450.0 235770.0 204070.0 154901.0 154877.0 152442.0 136307.0 199635.0 True False 261486.4514944393 227267.00387725714 207202.1480965296 203657.71927406456 178432.90219105288 176237.2066987245 162079.08738295326 152885.58098186826 163572.20873579278 193871.01883597823 1.3487650349414324 1.1722587792739312 1.0687628782300358 1.0504804714848393 0.9203691364618735 0.9090435886543076 0.8360150390506687 0.788594303056791 0.8437166613034652 1.0 17.564737630091145 -4.973093851910578 0.5834224448565792 0.8479856905736675 1.580097636739741 0.8691414028238309 0.059311039920671285 1.0062105631433786 0.3040677315877949 0.03211464020081875 0.48309566739886833 1.06391307962488e-05 4.973093851910578 0.7321119461660736 PVSSAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 2 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 164.92 1.5259e-05 24953500.0 27313.9 17692.9 28613.0 31304.0 27108.0 24019.9 21945.1 18537.2 19518.3 24489.8 False True 25795.902784204955 19049.88853835985 26772.070731478874 27040.341197587957 23702.450691405196 27328.42319405743 22965.590633390704 18591.140183001346 23422.50538686807 23782.715841858047 1.0846491610013544 0.8009971890944293 1.125694429076073 1.1369744892631828 0.9966250637233119 1.1490875716539852 0.9656420564454969 0.7817080398480216 0.9848541076054905 1.0 14.537625851061046 -7.518485233546762 24.9112476561675 0.9047036463854533 1.0440460264266196 0.21381954506061862 0.10951684679866662 263.62458905268596 1494782.0233264868 0.05015066784621707 0.02989883230571596 3.0305033362263544e-08 7.518485233546762 0.13934238004116628 PVSSAASVYAGAGGSGSRIS(ph)VSR ddPTM_A459_Selumetinib_30min_R1 1 PVSSAASVYAGAGGSGSRISVSR 23 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 PVSSAASVYAGAGGS(0.123)GS(0.123)RIS(0.687)VS(0.067)R 95.889 4.1342e-05 29408000.0 1182.6 1049.5 2024.6 2258.5 1732.4 1262.0 898.19 1458.4 776.49 1016.4 True False 1210.1522790609736 926.624052100687 1749.6704403317456 1864.0953722956735 1575.7047258800621 1249.3054258043203 830.4388051630827 1419.7184944491644 1317.646817414253 1146.8648405743938 1.0551829965027815 0.8079627339840658 1.5256117185137907 1.625383660172251 1.3739236483096726 1.0893222824571205 0.7240947457654794 1.2379126504027405 1.1489120346163242 1.0 10.163479662656862 -6.892069551871361 6.091024518089866 1.0287930991904668 1.283343156319282 0.18933249576764788 0.2478428837292007 0.40809643333897705 20.52090552037663 0.09829901698187256 0.08665994494528817 1.2821252350080627e-07 6.892069551871361 0.2545500571288153 PVSVAGS(ph)PLSPGPVR ddPTM_A459_Selumetinib_30min_R2 1 PVSVAGSPLSPGPVR 15 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 PVS(0.001)VAGS(0.889)PLS(0.11)PGPVR 76.156 0.037313 8262500.0 25877.0 27980.0 33058.0 26328.0 20848.0 33543.0 19986.0 21481.0 16984.0 28479.0 True False 24438.8599338385 30125.976030119895 30931.084270828946 22742.080981666746 18228.887856515255 38163.24377696277 20915.388601507682 21543.506153629027 20381.27457260967 27656.73727267169 0.8836494230281873 1.089281636264742 1.118392381786579 0.8222980446843512 0.6591120158822087 1.3798895871449313 0.7562493144183966 0.7789605093771022 0.7369370570240371 1.0 14.75534334810654 PVSVAGSPLS(ph)PGPVR ddPTM_A459_Selumetinib_30min_R1 2 PVSVAGSPLSPGPVR 15 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 PVS(0.007)VAGS(0.015)PLS(0.978)PGPVR;PVS(0.022)VAGS(0.203)PLS(0.774)PGPVR 99.238 0.0083644 41266000.0 4773.1 6121.9 4392.8 4050.7 3095.5 3717.0 4389.6 4641.5 2820.5 5444.6 True False 4884.3039431641555 5405.145102005902 3796.281887923192 3343.3212860562685 2815.5125715549125 3679.6103547659736 4058.488937912764 4518.392342283185 4786.182498830511 6143.467444895065 0.7950402581237384 0.8798199307619553 0.6179379840415246 0.544207536874703 0.4582937236681334 0.5989468305595985 0.6606186122602764 0.7354791708122029 0.7790685865532836 1.0 12.584837444095319 -8.591772180994234 1.2328105553537807 0.9969236963034688 0.6459218304278852 0.46532778211075 0.1131814229545869 0.5668709871661128 1.8575336591525158 0.12435493939254531 0.0383589405678792 2.559928403168707e-09 8.591772180994234 -0.3510018658755836 PVSVAGSPLS(ph)PGPVR ddPTM_A459_Selumetinib_30min_R2 4 PVSVAGSPLSPGPVR 15 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 PVS(0.009)VAGS(0.135)PLS(0.856)PGPVR;PVSVAGS(0.014)PLS(0.986)PGPVR;PVS(0.006)VAGS(0.063)PLS(0.931)PGPVR;PVSVAGS(0.008)PLS(0.992)PGPVR 158.14 0.00014873 71958500.0 191176.0 127204.0 156033.0 156745.0 155630.0 111973.0 134750.0 143184.0 113455.0 150492.0 True False 180551.2032581639 136960.13777467387 145994.00665588528 135396.06059979342 136078.36805014737 127396.26436030942 141016.14200205953 143600.64173461264 136149.1701975645 146146.9049348259 1.235409010807862 0.9371401866892162 0.9989538041944248 0.9264380977494747 0.9311067388723108 0.8717000501455825 0.9648931126180577 0.9825773717113697 0.9315911976259785 1.0 17.15705975084414 -4.760232089205422 24.99997192308338 0.9471521978848407 1.2354093559201935 0.8423924939499263 0.037105158463188695 11.311163991307094 234129.37963328496 0.009389672419044084 0.05646949052780341 1.7368723871501955e-05 4.760232089205422 0.2882571580353528 PVT(ph)PTSMCQGSSSGATIK ddPTM_A459_Selumetinib_30min_R2 2 PVTPTSMCQGSSSGATIK 18 0 H7C5W6;F5H619;Q86XA9-2;Q86XA9 H7C5W6 HEATR5A HEAT repeat-containing protein 5A 1 PVT(0.909)PT(0.023)S(0.068)MCQGSSSGATIK;PVT(0.696)PT(0.229)S(0.075)MCQGSSSGATIK 186.89 4.4664e-10 11602000.0 38334.0 21617.6 29274.0 40169.0 40413.0 28229.6 53304.0 63954.0 49469.0 21238.6 True False 36203.54974316055 23275.60040846032 27390.542711121256 34697.912904609955 35335.95764319604 32117.971157205644 55782.74161987222 64140.095551845356 59364.18227934689 20625.38643349012 1.755290736486549 1.1284928155657226 1.3280014316069408 1.6822915302216985 1.71322645309665 1.5572057891266773 2.7045671022820668 3.109764549560098 2.8782094566216374 1.0 14.332133529233097 -7.256158483824535 22.451371768927572 2.5989490312100494 1.515706103653427 0.3588629079159471 0.5672536754679866 94.5729887652368 402073.6329282044 0.21197735824101444 0.15872585237124623 5.544233544855157e-08 7.256158483824535 -1.0832429275566224 PVVDGEEGEPHSIS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 PVVDGEEGEPHSISPR 16 0 P36507;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 PVVDGEEGEPHS(0.025)IS(0.975)PR;PVVDGEEGEPHS(0.116)IS(0.884)PR 103.2 0.004421199999999999 2895000.0 22712.7 12713.5 19881.2 17507.0 23073.0 18201.5 29453.8 30341.2 28398.4 22707.3 True False 21450.41906014197 13688.584569654378 18602.065237013885 15122.516398740492 20174.363464762875 20708.59140823384 30823.460061597478 30429.48786874395 34078.87351759294 22051.681248349232 0.9727339525074863 0.6207501557587176 0.8435667569975608 0.6857761196721701 0.9148673626086042 0.9390935400802632 1.3977827683276935 1.379916910916798 1.545409310691177 1.0 14.428601032438408 -7.10864754778351 2.404119128570363 1.368708729702433 0.7908899344567153 0.6965390121745001 0.16246405038659506 0.1506151802834164 1.7059043856725071 0.06742160939208959 0.04972255517333762 7.786682238345031e-08 7.10864754778351 -0.5778187952457177 PY(ph)FPNRKFPS(ph)S(ph)S(ph)VAFK ddPTM_A459_Selumetinib_30min_R2 1 PYFPNRKFPSSSVAFK 16 2 F2Z2R4;A0A590UJK0;A0A590UJ12;A0A5F9UKL4;A0A590UJA1;A0A590UJV1;A0A590UJ07;Q5T890-2;Q5T890 F2Z2R4 ERCC6L2 DNA excision repair protein ERCC-6-like 2 4 PY(1)FPNRKFPS(1)S(1)S(1)VAFK 69.92 0.021554 474800000.0 1233.6 1159.3 1888.5 4130.3 4071.8 1407.5 903.13 1359.9 1415.1 2043.6 True False 1165.041450492065 1248.2145822629736 1766.9959660433324 3567.7460148350865 3560.264081646143 1601.3703489871239 945.1273345181443 1363.8570838564353 1698.1595411975932 1984.5959580895344 0.5870421360797231 0.6289514886771027 0.890355519893493 1.7977190774234806 1.7939490741850654 0.8068999346993926 0.4762316131228889 0.6872215366040292 0.8556701601026748 1.0 10.954629605081468 -6.976823532115025 24.975952127966753 0.7162655780842301 1.1505963836374622 0.1735065271867049 0.4060173985385823 423.08857886224456 455936.90266411775 0.16284630702987818 0.14360915158467735 1.054815414921023e-07 6.976823532115025 0.4343308055532321 PY(ph)T(ph)FEDY(ph)DVSFGS(ph)GVLT(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 PYTFEDYDVSFGSGVLTVK 19 0 C9JAX1;A0A2R8Y5A1;Q16595-2;Q16595-3;Q16595 C9JAX1 FXN Frataxin, mitochondrial;Frataxin intermediate form;Frataxin(56-210);Frataxin(78-210);Frataxin mature form 5 PY(0.981)T(0.988)FEDY(0.556)DVS(0.556)FGS(0.921)GVLT(0.998)VK 47.7 0.046095 0.0 1592.6 2052.2 1685.1 2057.6 2006.7 1931.5 2055.7 1593.5 591.36 1606.9 True False 1629.7044813398488 1811.9274699581035 1456.272675591734 1698.2787859356122 1825.19433931166 1912.0708636616828 1900.6368939464344 1551.2352035825165 1003.4947287744761 1813.161267531478 0.898819377251867 0.999319532357398 0.8031677610091303 0.936639678084304 1.0066365149066772 1.0545509094537768 1.0482448130684205 0.85554177191003 0.5534503448447696 1.0 10.824291532701086 -7.99934343344691 24.791687404900244 0.7526488071316609 0.9623656210160488 0.276414142724851 0.12251751487014584 20.670556000389738 780527.4629830959 0.06587347062937629 0.031186085009738185 1.0015129437039621e-08 7.99934343344691 0.2097168138843879 PYHPPPLFPPS(ph)PQPPDSTPR ddPTM_A459_Selumetinib_30min_R2 3 PYHPPPLFPPSPQPPDSTPR 20 0 P54259 P54259 ATN1 Atrophin-1 1 PY(0.002)HPPPLFPPS(0.997)PQPPDSTPR;PYHPPPLFPPS(1)PQPPDSTPR;PYHPPPLFPPS(1)PQPPDSTPR 144.43 2.1683e-05 16656900.0 69669.0 52153.0 64527.0 67670.0 72861.0 60291.0 79323.0 79516.0 74161.0 58228.0 True False 65797.07588710425 56152.967401674134 60375.403071685505 58453.22926273892 63707.54979439554 68595.53798279408 83011.67667554259 79747.37839541763 88995.27223147127 56546.8063454871 1.1635860650573309 0.9930351691056307 1.0677066836066147 1.033714068759322 1.1266339146574973 1.2130753691674856 1.4680170648075443 1.41028969714365 1.5738337491198355 1.0 15.787157925433226 -6.953434762204281 2.4201084685213727 1.3964618234241573 1.0651072469413536 0.4499488530106299 0.14654461882308428 0.22907522485458479 2.715229978050335 0.056583297145054286 0.04634864346042332 1.1131795971574205e-07 6.953434762204281 -0.33135457648280364 PYPS(ph)PGAVLR ddPTM_A459_Selumetinib_30min_R2 1 PYPSPGAVLR 10 0 H7C053;O60828-5;O60828-4;O60828-2;O60828 H7C053 PQBP1 Polyglutamine-binding protein 1 1 PYPS(1)PGAVLR 121.29 0.004823600000000001 5224300.0 12965.0 9520.8 11808.0 9809.7 13549.0 10259.0 11169.0 14819.0 11229.0 12691.0 True False 12244.45720300716 10251.014745802906 11048.286135578326 8473.601937323616 11846.853490403168 11672.084128070272 11688.380630953636 14862.120836582491 13475.11376447445 12324.57785482203 0.9934991159325167 0.8317538228534266 0.8964433723996194 0.6875368906861417 0.9612380748414883 0.947057519175274 0.9483797959360142 1.205892892369343 1.0933529669904491 1.0 13.589250611370895 -7.314393453889416 1.545871727285684 1.1066034290356017 0.8645812493060688 0.4870314594942259 0.09498302332452799 0.3153885254355086 1.4648807056383029 0.056011971577959646 0.032092407373599884 4.84849046771729e-08 7.314393453889416 -0.24202217972953288 PYQYPALT(ph)PEQK ddPTM_A459_Selumetinib_30min_R1 2 PYQYPALTPEQK 12 0 P04075;H3BQN4;J3KPS3;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 PYQYPALT(1)PEQK;PY(0.002)QY(0.004)PALT(0.993)PEQK 164.88 0.0012029000000000002 28238000.0 9869.5 13161.0 10271.1 10717.5 7145.2 8095.7 10353.1 9474.3 4175.0 9711.4 True False 10099.440147296023 11620.10400161709 8876.3410351138 8845.889817391586 6498.917921587521 8014.264608307477 9572.157331671366 9223.010787136387 7084.6700700646625 10957.952787046604 0.9216539205420351 1.0604265438479725 0.8100364372446032 0.807257522394905 0.593077744345631 0.7313651339857148 0.8735351865164643 0.8416727984116621 0.6465322681842042 1.0 13.419690672386974 -5.378108591184152 4.94576912526212 0.774251222474094 0.9895086981281046 0.33902293898332625 0.11290080919179331 0.22396827157618174 8.073737273320978 0.029582315164767593 0.0639119984946568 4.186888628802905e-06 5.378108591184152 0.21525747565401065 PYQYPALT(ph)PEQK ddPTM_A459_Selumetinib_30min_R2 1 PYQYPALTPEQK 12 0 P04075;H3BQN4;J3KPS3;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 PY(0.001)QY(0.001)PALT(0.999)PEQK 114.74 0.012691 6605200.0 52558.0 42346.0 45573.0 39855.0 41964.0 27753.0 34183.0 38233.0 29905.0 38015.0 True False 49637.03676634402 45593.80203614932 42640.88279613068 34426.68024629017 36692.10715708011 31575.72383334968 35772.57723232952 38344.2517001861 35886.835615514115 36917.40817516816 1.3445428381868771 1.2350217496258902 1.1550345732237053 0.9325324270582642 0.9938971604664383 0.8553071679227073 0.9689894009512647 1.0386496126230682 0.9720843739960261 1.0 15.172013650190603 -5.449459763871263 1.8444582539273815 0.9625480498434246 1.3166894113247845 0.8626454538244717 0.052691459413906336 0.12951709249358845 0.833767230825921 0.01594356508423717 0.04890142196912751 3.5525503030965574e-06 5.449459763871263 0.3541413614813599 PYQYPALTPEQK ddPTM_A459_Selumetinib_30min_R1 1 PYQYPALTPEQK 12 0 P04075;H3BQN4;J3KPS3;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 137.17 0.037428 0.0 1630.1 2135.3 1802.5 2171.8 1886.2 1310.2 1928.9 1828.5 984.33 1912.5 False True 1668.078158377552 1885.2980833259617 1557.7304004237733 1792.5358997351102 1715.5935430356574 1297.0205775664185 1783.4015200337012 1780.0022401949377 1670.3361173812575 2157.988004327556 0.7729784201916065 0.8736369616259445 0.7218438644236916 0.8306514661529255 0.7949967931217709 0.6010323389033754 0.8264186438744461 0.8248434359344822 0.7740247462134275 1.0 11.075471129958245 -9.73102233893199 0.8600744603704149 1.0063180782368426 0.7775011463107181 0.4595489777357158 0.07156401804214363 10.128797994668052 6.1512148903963455 0.299267997956047 0.02358827954352743 1.8577088971194917e-10 9.73102233893199 -0.2288169319261245 PYQYPALTPEQK ddPTM_A459_Selumetinib_30min_R2 2 PYQYPALTPEQK 12 0 P04075;H3BQN4;J3KPS3;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 171.62 0.0035792000000000007 13185400.0 103972.0 81356.0 78147.0 91028.0 82782.0 58588.0 76151.0 83161.0 58685.0 77045.0 False True 98193.65247289318 87595.74359922908 73119.10710002019 78629.8293679415 72382.1850795302 66657.96519108895 79692.17239034384 83402.98474195527 70423.63979590204 74820.51066304953 1.3123894985841977 1.1707450647284698 0.9772601984676164 1.0509127600324335 0.9674110005142814 0.8909049751247997 1.0651113135171397 1.1147075047049129 0.9412344178329846 1.0 16.19114619211735 -4.995643526129538 2.433067323778017 1.0033336318440145 1.325334030693456 0.7271586017316428 0.06171344019263703 0.19495000891207043 1.9550831569802203 0.017275976554682927 0.10907310580516551 1.0100816324471256e-05 4.995643526129538 0.32200039884944154 PYT(ph)T(ph)Y(ph)LFEVSAVT(ph)TEAGYIDS(ph)TIVR ddPTM_A459_Selumetinib_30min_R2 1 PYTTYLFEVSAVTTEAGYIDSTIVR 25 0 Q9UMZ3 Q9UMZ3 PTPRQ Phosphatidylinositol phosphatase PTPRQ 5 PY(0.442)T(0.843)T(0.843)Y(0.821)LFEVS(0.053)AVT(0.543)T(0.439)EAGY(0.061)IDS(0.477)T(0.477)IVR 46.099 0.01704 4342900.0 683.16 842.69 1022.2 834.12 2143.3 0.0 632.19 2573.2 631.68 1025.8 True False 645.1927021061604 907.3216133245793 956.4327648872088 720.5114170627419 1874.0394926548906 0.0 661.5880876607201 2580.6875859838065 758.0336506138758 996.1824886515196 0.6476651712474129 0.9107985973059749 0.9600979497058637 0.7232725181086657 1.8812210754594576 0.0 0.6641233862244231 2.590577143628723 0.7609385421339684 1.0 9.960266240659088 QAAS(ph)PLEPK ddPTM_A459_Selumetinib_30min_R1 2 QAASPLEPK 9 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;Q14980-4;Q14980-3;F5H6Y5;F5H4J1 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 QAAS(1)PLEPK;QAAS(1)PLEPK 105.25 0.013855 51595000.0 11245.7 11949.8 14222.5 13737.7 12101.5 11337.6 12253.8 12461.8 6685.3 11148.0 True False 11507.702929676965 10550.711860688702 12291.162618600354 11338.668583567096 11006.921461693353 11223.554037717164 11329.486000409022 12131.272582368756 11344.465825006779 12578.954390715606 0.9148377975017288 0.8387590520620753 0.9771211689639587 0.9013999281161277 0.8750267406818365 0.8922485676552855 0.9006699323730116 0.9644102526774977 0.901860796425179 1.0 13.618724384594678 -9.296670944723061 0.47276099895215473 1.0083579301698218 0.8979988997550665 0.36966933466135965 0.0372302246844085 3.284477818775854 1.0985035734523085 0.09442179333145202 0.020518861685137404 5.050438131062854e-10 9.296670944723061 -0.11035903041475525 QAAS(ph)PLEPK ddPTM_A459_Selumetinib_30min_R2 4 QAASPLEPK 9 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;Q14980-4;Q14980-3;F5H6Y5;F5H4J1 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 QAAS(1)PLEPK;QAAS(1)PLEPK;QAAS(1)PLEPK;QAAS(1)PLEPK 117.95 0.0073697 62896600.0 631200.0 547077.0 573308.0 623810.0 576690.0 433225.0 517878.0 567286.0 419234.0 498702.0 True False 596120.4308938001 589036.0467701886 536421.9874505546 538846.0018677267 504241.04652598733 492897.811325007 541960.3531557886 568936.7083407473 503092.5143766746 484303.1774765932 1.2308827581925397 1.2162547638842556 1.1076160809960418 1.1126212400160633 1.0411681565941362 1.0177463916160847 1.1190518220004495 1.1747532017137023 1.0387966418019001 1.0 18.88555094282067 -5.301919156263039 1.8313090936382952 1.0766500535122019 1.2405898278336622 0.5914190699034372 0.04969355222599997 0.3086226227764398 1.8436521905942027 0.014978048167175967 0.05980330390770374 4.989773632437378e-06 5.301919156263039 0.16393977432146034 QACTAQT(ph)PEPLR ddPTM_A459_Selumetinib_30min_R1 4 QACTAQTPEPLR 12 0 F2Z2E2;Q86VI3 F2Z2E2 IQGAP3 Ras GTPase-activating-like protein IQGAP3 1 QACT(0.01)AQT(0.99)PEPLR;QACT(0.012)AQT(0.988)PEPLR;QACTAQT(1)PEPLR;QACT(0.001)AQT(0.999)PEPLR 145.49 0.0015942 22051400.0 4570.629999999999 5650.83 4362.91 4485.68 4927.94 4470.34 4803.26 5162.799999999999 2577.59 3891.91 True False 4677.116786102192 4989.228196600404 3770.450785749177 3702.3401946421313 4482.208697098473 4425.372438343967 4440.946231073187 5025.865772862136 4373.9819702749655 4391.474558913702 1.0650447186603191 1.1361168394960635 0.8585842261333413 0.8430744946767861 1.0206614286312103 1.007719019881707 1.0112653896762465 1.1444597265537524 0.9960166936175845 1.0 12.100489730490128 -7.156267761188139 2.010429956751666 1.0523402695057122 0.9795388420241041 0.06861300561614858 0.09063189702808631 0.8789559722089104 6.9723363797319005 0.0474849132942335 0.032844888288716574 6.978020465123073e-08 7.156267761188139 -0.07280142748160812 QACTAQT(ph)PEPLR ddPTM_A459_Selumetinib_30min_R2 3 QACTAQTPEPLR 12 0 F2Z2E2;Q86VI3 F2Z2E2 IQGAP3 Ras GTPase-activating-like protein IQGAP3 1 QACTAQT(1)PEPLR;QACT(0.004)AQT(0.996)PEPLR;QACT(0.009)AQT(0.991)PEPLR 127.03 0.0062009 29691800.0 57869.0 41018.0 51740.0 67244.0 74046.0 64354.0 81507.0 77233.0 64495.0 68514.0 True False 54652.87264796156 44163.94870634231 48411.10473025261 58085.2511976298 64743.67950036111 73218.17935255243 85297.23700305661 77457.73524338864 77395.8021408655 66535.82279924951 0.821405227269212 0.6637619683398648 0.7275945903053996 0.8729921530073116 0.973064986296245 1.1004324628774005 1.2819746328292 1.1641508586598905 1.1632200352339896 1.0 16.02184367444506 -6.3704618949895115 1.4329924825864078 1.1673789611758272 0.7304027116135907 0.8381908357723985 0.07777591877673874 0.14385289394693412 0.5968186054846347 0.030180401202589368 0.03811636461638632 4.261260702564232e-07 6.3704618949895115 -0.43697624956223646 QADFEAHNILR ddPTM_A459_Selumetinib_30min_R1 2 QADFEAHNILR 11 0 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 0 ; 156.69 0.00077348 6096600.0 8028.400000000001 7076.2 8458.4 7753.6 7184.5 4672.5 5668.8 5108.9 3555.2 4365.0 False True 8215.446099453004 6247.715214363868 7309.79573866544 6399.579313097957 6534.6632435264955 4625.498892290558 5241.197852022938 4973.3953759540145 6032.9147384656035 4925.29026870054 1.6680125741341372 1.2684968547066422 1.4841350133449118 1.2993303874426034 1.3267569802034356 0.939132241948234 1.0641398914760296 1.0097669588245743 1.2248851152598754 1.0 12.265993036007671 -6.618864364078711 4.380600990726232 1.0500757093395758 1.4116114927773327 0.6847620413800322 0.12372647892036549 0.12937200166291904 4.459928054052736 0.04050105858766424 0.040506562588889565 2.405113831640691e-07 6.618864364078711 0.36153578343775683 QADLYISEGLHPR ddPTM_A459_Selumetinib_30min_R1 1 QADLYISEGLHPR 13 0 P40227;Q92526-3;Q92526 P40227 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 82.65100000000002 0.045822 5547700.0 3085.1 3455.4 3746.3 3540.6 3849.3 3232.2 3481.4 3432.1 2043.1 2871.3 False True 3156.976827440392 3050.8401616281226 3237.5730369528897 2922.300675293365 3501.131494649114 3199.687002602793 3218.79519510878 3341.0695589680295 3466.991477880026 3239.859323830438 0.9744178718562214 0.9416582192899534 0.9992943252626026 0.9019838157165331 1.0806430603010806 0.9876005970592113 0.9934984434148967 1.031239083250668 1.0701055605652203 1.0 11.661715456655232 -6.260980907254556 24.99997286907666 1.0250799167734035 0.9566439477209869 0.483901449984274 0.036784332946716236 39.54986349388819 2156596.3004105985 0.01091621566534333 0.013265177784821178 5.483010691705432e-07 6.260980907254556 -0.06843596905241656 QADPQPQAWPPPDS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 QADPQPQAWPPPDSPVR 17 0 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ERU2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 QADPQPQAWPPPDS(1)PVR;QADPQPQAWPPPDS(1)PVR 109.77 0.0030786 0.0 1473.04 1429.25 1312.28 1766.59 1532.54 1336.35 1560.4 1449.15 960.2900000000001 1142.83 True False 1507.3589659631114 1261.912745559702 1134.0795838380639 1458.088219501356 1393.9220275919122 1322.9075323087181 1442.6977717147524 1410.7138344973987 1629.5419931933886 1289.5233626068812 1.1689272251073117 0.9785885096402116 0.8794564074786714 1.1307187304879118 1.0809591109493202 1.025888766865261 1.1187837409926533 1.0939808268735207 1.263677759121115 1.0 10.332622195681239 -7.37796447294937 1.8214964843116976 1.1360202784908795 1.0371221470120011 0.11371829499018371 0.09665107906723701 0.7019695321959959 4.5376781036152565 0.05535170235185059 0.03130733637800169 4.188278255319668e-08 7.37796447294937 -0.09889813147887838 QADPQPQAWPPPDS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 QADPQPQAWPPPDSPVR 17 0 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ERU2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 QADPQPQAWPPPDS(1)PVR;QADPQPQAWPPPDS(1)PVR 234.51 6.0022e-17 15263000.0 46323.0 32782.0 38858.0 43050.0 54202.0 45417.0 54093.0 56957.0 51204.0 38277.0 True False 43748.553105661456 35296.27398925629 36357.91858539148 37186.51573460777 47392.66018797196 51672.779495522744 56608.43168324607 57122.73544026103 61446.23075929729 37171.84355441044 1.1769271825763585 0.9495432729235294 0.9781037233779494 1.0003947122013426 1.274961251749614 1.390105374243451 1.5228846963262728 1.536720538400184 1.6530315659312165 1.0 15.18192262063721 -6.519123262525861 2.109650817765037 1.4672800797895555 1.0143800652552881 0.5295010102231682 0.1726684431990516 0.22013070795883305 1.9687528084889843 0.06031793647102492 0.06527399901785635 3.026054444007617e-07 6.519123262525861 -0.4529000145342674 QADPQPQAWPPPDS(ph)PVRVDTVR ddPTM_A459_Selumetinib_30min_R1 2 QADPQPQAWPPPDSPVRVDTVR 22 1 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ERU2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 QADPQPQAWPPPDS(0.999)PVRVDT(0.001)VR;QADPQPQAWPPPDS(0.881)PVRVDT(0.119)VR 144.55 7.2902e-07 49763000.0 4833.700000000001 4708.7 9581.4 8746.3 7631.200000000001 5975.299999999999 5878.799999999999 5910.6 3731.9 5031.0 True False 4946.3158052570825 4157.40321498476 8280.298506862884 7218.922893384833 6940.959307397792 5915.193907138312 5435.357382950962 5753.831687665408 6332.761732808218 5676.7778560899005 0.8713245313890172 0.7323526339021361 1.4586264808618492 1.2716585141059482 1.2226934862268233 1.0419984817254466 0.9574722704923272 1.0135735153865226 1.115555671429805 1.0 12.470856571776372 -6.977653414377428 24.109447006825572 1.0194891406660351 1.1198648633304094 0.04660244950506831 0.19333964621863325 576.401641896988 621868.9505441962 0.07530172320694048 0.06640448873115662 1.0528017195869514e-07 6.977653414377428 0.10037572266437422 QADPQPQAWPPPDS(ph)PVRVDTVR ddPTM_A459_Selumetinib_30min_R2 4 QADPQPQAWPPPDSPVRVDTVR 22 1 Q63ZY3-3;Q63ZY3;Q63ZY3-2;K7ERU2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 QADPQPQAWPPPDS(0.992)PVRVDT(0.008)VR;QADPQPQAWPPPDS(0.998)PVRVDT(0.002)VR;QADPQPQAWPPPDS(0.993)PVRVDT(0.007)VR;QADPQPQAWPPPDS(0.986)PVRVDT(0.014)VR 127.37 1.5697e-05 82147000.0 294724.0 278781.0 316417.0 338799.0 322678.0 227789.0 241586.0 264198.0 241471.0 296491.0 True False 278344.4199536508 300162.6062777998 296059.07470878074 292653.9917391264 282140.30486207915 259164.86708733815 252820.22769357706 264966.77243966685 289771.94726346125 287930.5344538674 0.9667068499060056 1.0424827184346168 1.0282309073969218 1.016404850198393 0.9798901856561657 0.9000951134929451 0.8780598006846135 0.9202454784527904 1.0063953370318524 1.0 18.135361266357542 -6.532211712891718 4.284167600846514 0.9321365989477362 1.0153395976913582 0.3904461907630473 0.04189753372640777 0.19185648491455023 8.51189175918689 0.014246238416172586 0.014942789154606855 2.936217935097032e-07 6.532211712891718 0.08320299874362203 QADVFPDRDHFGR ddPTM_A459_Selumetinib_30min_R2 1 QADVFPDRDHFGR 13 1 A0A0G2JM88;D6R9R1;D6RDF7;Q9HCC0-2;Q9HCC0 A0A0G2JM88 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 75.102 0.038085 2536600.0 6180.8 3703.3 4350.7 8619.9 4868.8 4708.9 6848.4 5874.8 5389.4 5031.8 False True 5837.295879702789 3987.331202013691 4070.7806986839955 7445.854749843098 4257.137816375744 5357.508231861788 7166.864169847152 5891.894695374502 6467.430592417717 4886.518859813528 1.194571441790269 0.8159860457728488 0.8330635398057868 1.523754427937936 0.8712005291509707 1.0963854608076213 1.4666604950176418 1.205744797964279 1.3235251470337142 1.0 12.254591344488484 -5.727311476296942 24.999992739988713 1.2125755965359488 0.9346848188942991 0.24938854289315104 0.20998360308243022 251.81363079791456 184461.33124330692 0.05634655734157289 0.09758866459444397 1.873650242846274e-06 5.727311476296942 -0.2778907776416497 QAEEECAHRGS(ph)PLPK ddPTM_A459_Selumetinib_30min_R2 1 QAEEECAHRGSPLPK 15 1 F2Z2A4;H7C1J2;H7C1M5;Q9H147 F2Z2A4 DNTTIP1 Deoxynucleotidyltransferase terminal-interacting protein 1 1 QAEEECAHRGS(1)PLPK 55.335 0.044004 29248000.0 252610.0 266420.0 294680.0 282820.0 272680.0 203980.0 229850.0 214480.0 179400.0 273710.0 True False 238570.94747795144 286853.5573246797 275720.609623325 244299.42810828678 238423.50060987056 232076.393453921 240538.48043913438 215104.10129092468 215285.01285481482 265807.2811160142 0.8975335305951413 1.0791787046626449 1.0372951729000384 0.9190847860998207 0.8969788171671953 0.873100211850965 0.9049356339270067 0.8092483410830285 0.809928952852317 1.0 18.02002109856216 -5.947500332774526 3.2295534525312397 0.8745762555642728 1.0117091748796634 0.39648376060556867 0.06649567677122259 0.2220457537224349 4.744130192232852 0.019531303518860878 0.029800856999552993 1.1284950728274893e-06 5.947500332774526 0.13713291931539062 QAEQLS(ph)AAGEGGDAGR ddPTM_A459_Selumetinib_30min_R1 1 QAEQLSAAGEGGDAGR 16 0 F8WBJ6;Q9NRX1 F8WBJ6 PNO1 RNA-binding protein PNO1 1 QAEQLS(1)AAGEGGDAGR 157.7 7.4327e-05 7148500.0 603.05 951.8 940.84 934.84 1099.5 718.37 1074.8 853.19 761.51 760.2 True False 617.0998916689665 840.3628135201848 813.0790956641907 771.587743120163 1000.0504191324919 711.1438500277727 993.7269706735558 830.5606296483014 1292.2268515101646 857.7790749750633 0.7194158841971127 0.9796960989571997 0.9478887039624135 0.8995180293277661 1.1658601244866746 0.8290524574156191 1.1584882397631868 0.9682686998076362 1.5064798025619024 1.0 9.744462312465473 -5.465163786975973 0.37084603748639017 1.1670830722722398 0.6709494884639682 0.3095228312121493 0.17196457382166 4.842610878956086 0.7730029979877121 0.1596616238122587 1.0264941506677336 3.426385417216058e-06 5.465163786975973 -0.49613358380827166 QAEQLS(ph)AAGEGGDAGR ddPTM_A459_Selumetinib_30min_R2 2 QAEQLSAAGEGGDAGR 16 0 F8WBJ6;Q9NRX1 F8WBJ6 PNO1 RNA-binding protein PNO1 1 QAEQLS(1)AAGEGGDAGR;QAEQLS(1)AAGEGGDAGR 183.39 8.723700000000002e-07 17218800.0 46263.0 40631.0 46647.0 50986.0 49701.0 44154.0 44069.0 52017.0 42483.0 48185.0 True False 43691.88766546238 43747.26705074343 43645.78280541345 44041.618844244156 43457.11604742251 50235.812709895225 46118.295821066844 52168.36085812208 50980.78707419787 46793.77385033486 0.9337115618245806 0.9348950394696659 0.9327262841635741 0.9411854445659119 0.9286944067904352 1.0735576247936185 0.9855647883535006 1.114856882989974 1.089477998446006 1.0 15.51402896421286 -6.75798553705456 24.997498499402113 1.055674605390872 0.9345802597526773 0.7283876638718396 0.036142261012155216 46.59244776383788 337216.98306048405 0.012190214175469971 0.011724997643975226 1.7458802935417608e-07 6.75798553705456 -0.12109434563819477 QAEVANQETKEDLPAENGET(ph)KTEESPASDEAGEK ddPTM_A459_Selumetinib_30min_R2 1 QAEVANQETKEDLPAENGETKTEESPASDEAGEK 34 2 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 QAEVANQET(0.003)KEDLPAENGET(0.67)KT(0.191)EES(0.068)PAS(0.068)DEAGEK 47.383 0.01958 6390700.0 17569.0 16851.0 15074.0 13511.0 12020.0 11240.0 13592.0 7982.4 5371.5 13847.0 True False 16592.58531427943 18143.417515495014 14104.155251330267 11670.778492224976 10509.940139836599 12788.207973438919 14224.054932037046 8005.627462442543 6445.950092249932 13447.201131173317 1.2339062346449536 1.3492337430303563 1.0488543388135987 0.867896477369537 0.7815708292986295 0.9509940283255882 1.0577706686533324 0.5953378241576152 0.4793525455127553 1.0 13.715018304422934 -5.5604042609232485 2.213797312770362 0.810819708932004 1.296563014086805 0.558584556954385 0.16866334504374986 0.24453468958518912 2.381559859659554 0.052690274843150815 0.12339159922975519 2.751666135699192e-06 5.5604042609232485 0.485743305154801 QAFQIGS(ph)PWR ddPTM_A459_Selumetinib_30min_R2 2 QAFQIGSPWR 10 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 QAFQIGS(1)PWR;QAFQIGS(1)PWR 89.266 0.031084 7308800.0 50089.0 50133.0 54106.0 52960.0 50444.0 42347.9 44018.8 42576.0 41427.1 46871.0 True False 47305.25390215389 53978.03989699786 50624.87886615864 45746.75663890421 44106.773744918275 48180.938829038634 46065.76142159747 42699.88911116376 49713.677569886844 45517.712444516845 1.0392713377197051 1.1858689068083905 1.1122017374635664 1.005031979466599 0.9690024251258581 1.058509671103707 1.0120403453435551 0.9380939159280504 1.0921831282818664 1.0 15.47414043438465 -5.745950147859585 6.779821779648998 1.008291091474158 1.120559511466351 0.44328662164961863 0.052000744016341104 0.12479224852742649 24.104455147775518 0.013696362937722717 0.02280978266512502 1.7949396539681452e-06 5.745950147859585 0.11226841999219284 QAFQIGSPWR ddPTM_A459_Selumetinib_30min_R2 1 QAFQIGSPWR 10 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 147.4 0.01144 41826000.0 78967.0 65946.0 66425.0 90989.0 84173.0 63049.0 64011.0 69982.0 59357.0 61319.0 False True 74578.33026994721 71003.846150189 62151.28781807162 78596.14123522013 73598.43522383238 71733.42744816281 66987.6383353902 70185.6360338563 71230.05857315085 59548.56114410463 1.2523951685326413 1.1923687959204108 1.043707633298956 1.3198663364009968 1.2359397743587412 1.2046206670648414 1.1249245497852312 1.1786285795220217 1.1961675849862696 1.0 15.861779028607042 -13.848075107964863 0.2975689149620488 0.0007669559798701557 1.2033378655163958 0.4185028459977582 0.06934692972467602 176.47788729047338 2.405152585472689 108.3899181175383 0.0729460054260827 1.4188121275818046e-14 13.848075107964863 1.2025709095365256 QAGAPGGSSGSGGS(ph)PELSALR ddPTM_A459_Selumetinib_30min_R1 1 QAGAPGGSSGSGGSPELSALR 21 0 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 QAGAPGGSSGS(0.001)GGS(0.994)PELS(0.005)ALR 246.98 9.014899999999999e-39 9703100.0 1703.3 1661.8 1707.0 1620.9 2090.5 1547.7 1728.4 1658.6 985.49 1270.5 True False 1742.9835759551463 1467.235683450139 1475.1987758798234 1337.840243061349 1901.4146441077512 1532.1315431991654 1598.0253964571766 1614.6085401079158 1672.3045526582084 1433.5810507179917 1.2158249267330885 1.0234759190736316 1.0290306049602065 0.9332156297624803 1.3263391303585177 1.0687442767409738 1.1147087886358604 1.1262764245518302 1.1665225009919424 1.0 10.485407757544223 -4.738912645028334 24.456181015679086 1.0926017157861865 1.215825576170975 0.12179055770082825 0.10251244736086505 3393.5765050063533 3683990.4338216097 0.025633396156668927 1.3026251933122095 1.8242626017133527e-05 4.738912645028334 0.12322386038478861 QAGAPGGSSGSGGS(ph)PELSALR ddPTM_A459_Selumetinib_30min_R2 3 QAGAPGGSSGSGGSPELSALR 21 0 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 QAGAPGGS(0.003)S(0.001)GS(0.003)GGS(0.665)PELS(0.329)ALR;QAGAPGGS(0.086)S(0.005)GS(0.006)GGS(0.836)PELS(0.067)ALR;QAGAPGGSSGSGGS(0.938)PELS(0.062)ALR 279.86 7.147399999999997e-73 25696000.0 57811.0 52516.0 61799.0 67645.0 78906.0 53376.0 55125.0 55624.0 47033.0 51257.0 True False 54598.0960557691 56543.80833444518 57822.91962166372 58431.634305866246 68993.12285140993 60728.059500914176 57688.42172811528 55785.856630951086 56440.91421181996 49777.07722832029 1.0968521877115343 1.1359407077094317 1.1616375014635414 1.1738663167756667 1.3860420637987323 1.2200005079117704 1.1589354968253116 1.1207137850836317 1.1338736091903028 1.0 15.603193901310723 -8.562763152525703 1.0298619849621453 1.004091498649986 1.1945653163067 0.3683983130519609 0.07424230525645753 0.7096084658752231 1.6425411934080851 0.07815664702699301 0.025637261320340807 2.736760843297284e-09 8.562763152525703 0.190473817656714 QAGAPGGSSGSGGSPELS(ph)ALR ddPTM_A459_Selumetinib_30min_R1 2 QAGAPGGSSGSGGSPELSALR 21 0 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 QAGAPGGS(0.001)S(0.007)GS(0.073)GGS(0.232)PELS(0.686)ALR;QAGAPGGSS(0.002)GSGGS(0.169)PELS(0.828)ALR 164.42 1.7965e-08 12595300.0 3215.7 3556.7000000000003 3717.3 3678.2 3934.9 3532.4 3666.6 4259.299999999999 2152.7 3250.6000000000004 True False 3290.6195533370287 3140.2799105350305 3212.5110776672946 3035.8714183652633 3578.988989763021 3496.867263162581 3390.0254100034026 4146.329527843748 3652.974673012741 3667.8461735253113 0.8971530968471028 0.8561645614261909 0.8758576357033053 0.8276986751184736 0.9757740157142724 0.9533843835663381 0.9242550667671855 1.1304534955070233 0.9959454405094974 1.0 11.840717419411359 -6.921262136553616 0.9694857921338756 1.0369130001697402 0.8649970283637223 0.5969266552322168 0.053180384103666795 0.35981614238557025 0.7111201757372386 0.03339588046147845 0.02600001682939072 1.1987755137596465e-07 6.921262136553616 -0.17191597180601792 QAGAPGGSSGSGGSPELS(ph)ALR ddPTM_A459_Selumetinib_30min_R2 1 QAGAPGGSSGSGGSPELSALR 21 0 Q9Y2J4;Q9Y2J4-2;Q9Y2J4-4 Q9Y2J4 AMOTL2 Angiomotin-like protein 2 1 QAGAPGGS(0.001)S(0.001)GS(0.001)GGS(0.1)PELS(0.897)ALR 184.38 6.1327e-15 11478000.0 25839.0 24789.0 27263.0 29337.0 27642.0 24918.0 24256.0 27570.0 21516.0 24530.0 True False 24402.97182171244 26690.23659080207 25508.92826171001 25341.249990852222 24169.36483738464 28350.22831691734 25383.952062352186 27650.224135540797 25819.801207269767 23821.755163405913 1.0243985656942427 1.1204143610628075 1.0708248861904126 1.063786014801315 1.0145921100940838 1.190098215788394 1.0655785809328635 1.1607131357817007 1.0838748459195475 1.0 14.539992093014098 -6.727652222110328 24.999997419691137 1.107943187650211 1.0631707763131268 0.11117031734015792 0.055460697832419546 373.136536818718 276092.92512255383 0.0171964942230191 0.01719538729023785 1.8721807604791873e-07 6.727652222110328 -0.044772411337084206 QAGEVTYADAHK ddPTM_A459_Selumetinib_30min_R1 2 QAGEVTYADAHK 12 0 Q13247-3;Q13247;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;A0A0D9SEM4;Q08170 Q13247-3;Q08170 SRSF6;SRSF4 Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 4 0 ; 172.58 0.00030791 11785500.0 8230.0 7778.0 8681.8 8414.4 8654.8 7410.5 8286.0 8472.1 4611.4 7920.5 False True 8421.742987207683 6867.348144105899 7502.859245713799 6944.982997850215 7871.974868129046 7335.957098195655 7660.980348903133 8247.392386740783 7825.208996669747 8937.173327203347 0.942327364466931 0.7684027032577262 0.8395114395819401 0.7770894379670115 0.8808125992329134 0.8208363908380469 0.8572039579432029 0.9228188919238055 0.8755798629138191 1.0 13.125602888815365 -8.609729704089018 0.5858850229824639 1.000425236177442 0.829702495295186 0.4712323662143262 0.05012165269017138 0.8018809510594839 0.6307311377761589 0.05146716255725326 0.021805208917984972 2.456237151310195e-09 8.609729704089018 -0.17072274088225592 QAGIGGEPAAAGAGCS(ph)PRPK ddPTM_A459_Selumetinib_30min_R2 2 QAGIGGEPAAAGAGCSPRPK 20 1 J3QQY0;J3KSZ8;Q68DK7 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 QAGIGGEPAAAGAGCS(1)PRPK;QAGIGGEPAAAGAGCS(1)PRPK 154.17 2.4149e-06 38877000.0 74689.0 76733.0 65923.0 87361.0 77331.0 55023.0 74959.0 74027.0 56262.0 79415.0 True False 70538.08438375643 82618.174364517 61681.58595153542 75462.28109386933 67615.98843208849 62601.91880093684 78444.74202844063 74242.40631417047 67515.9720916254 77122.08260505013 0.9146288845049606 1.071264825505464 0.7997914976883205 0.9784782586891382 0.8767396593574462 0.8117249520027552 1.0171502036603959 0.9626608074677291 0.8754428019972103 1.0 16.234856390186437 -9.78079744188956 8.785661446296078 0.9999986187860125 0.9247487022644166 0.07272060609193765 0.08219259492101787 0.0 0.0 0.07767469250341179 0.01883888009581995 1.656542406766299e-10 9.78079744188956 -0.07524991652159585 QAHDLS(ph)PAAESSSTFSFSGR ddPTM_A459_Selumetinib_30min_R1 4 QAHDLSPAAESSSTFSFSGR 20 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 QAHDLS(1)PAAESSSTFSFSGR;QAHDLS(1)PAAESSSTFSFSGR;QAHDLS(0.977)PAAES(0.015)S(0.001)S(0.006)T(0.001)FSFSGR;QAHDLS(1)PAAESSSTFSFSGR 158.75 8.0711e-07 128522600.0 11266.36 11097.56 12315.430000000002 11799.27 13165.490000000002 9946.4 11916.54 11721.970000000001 6377.9 8754.55 True False 11528.844267479612 9798.252516084323 10643.062249814677 9738.748994229438 11974.673754056043 9846.348246608626 11017.665793738612 11411.065277275278 10822.830476614465 9878.281769038325 1.1670900402552469 0.9918984642445775 1.0774203954349042 0.9858747929982897 1.2122223311738765 0.9967672999033305 1.115342328892812 1.1551670162964154 1.095618724962539 1.0 13.270044405534406 QAHDLS(ph)PAAESSSTFSFSGR ddPTM_A459_Selumetinib_30min_R2 3 QAHDLSPAAESSSTFSFSGR 20 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 QAHDLS(1)PAAESSSTFSFSGR;QAHDLS(1)PAAESSSTFSFSGR;QAHDLS(1)PAAESSSTFSFSGR 113.52 0.00019915 113187100.0 197514.0 167829.0 214787.0 236162.0 248012.0 198434.0 173110.0 192799.0 169890.0 199791.0 True False 186536.9625911884 180700.94464471005 200967.8382624033 203996.3281978265 216854.51530458874 225766.4822954964 181159.95801095729 193360.01317040712 203872.74712321322 194022.5147106414 0.9614191573044154 0.9313400814034459 1.0357964824964767 1.0514054438582021 1.1176770676743275 1.1636097111317047 0.9337058551227062 0.9965854398845293 1.0507685019301092 1.0 17.565864549409476 -5.314442196870747 5.412486395507856 1.0474420954021144 0.9463042956663837 0.2910184201540533 0.060633704918878165 0.24948133101292083 16.574412047846696 0.017375174467199578 0.038086597622863864 4.847946328594023e-06 5.314442196870747 -0.10113779973573067 QAIEEEGGDPDNIELTVSTDT(ph)PNKKPTK ddPTM_A459_Selumetinib_30min_R2 1 QAIEEEGGDPDNIELTVSTDTPNKKPTK 28 2 Q9NWH9;H7BXE3;H0YL55;H0YMW8;H0YNF3;H0YMR6;H0YLE6;H0YKU6 Q9NWH9 SLTM SAFB-like transcription modulator 1 QAIEEEGGDPDNIELT(0.075)VS(0.075)T(0.352)DT(0.495)PNKKPT(0.002)K 85.42299999999999 4.223e-05 8770400.0 61531.0 56032.0 55922.0 57617.0 53803.0 50888.0 60788.0 55077.0 49559.0 59830.0 True False 58111.35334810898 60329.474228723295 52324.03940326989 49769.465205131164 47043.78613507724 57897.360084729546 63614.76244913686 55237.26495151184 59472.18479415702 58102.552442991255 1.0001514719190068 1.038327434718415 0.9005463134276055 0.8565796701266041 0.8096681497983311 0.9964684450229094 1.0948703589494462 0.950685686411268 1.0235726709684505 1.0 15.826313922111451 -6.978019866403942 24.984802463441355 1.0178150806333788 0.9208704351017996 0.31064662557329015 0.06912911732917716 320.3862667607389 364181.7438715912 0.02698799410634027 0.023799428766541484 1.0519137538898615e-07 6.978019866403942 -0.09694464553157922 QAIGLMGY(ph)RLSPQT(ph)LT(ph)T(ph)IVK ddPTM_A459_Selumetinib_30min_R2 1 QAIGLMGYRLSPQTLTTIVK 20 1 H7C2Z6;H7BXD5;P28676 H7C2Z6 GCA Grancalcin 4 QAIGLMGY(0.704)RLS(0.298)PQT(0.998)LT(1)T(1)IVK 47.554 0.042618 0.0 3535.3 3282.2 4031.5 3739.9 5664.5 4270.5 3438.6 2627.4 3382.3 4902.8 True False 3338.822178927206 3533.934186063598 3772.117679165314 3230.5191683126486 4952.874868727486 4858.722611260759 3598.5017134566388 2635.0452990105164 4058.8545093580833 4761.24342499578 0.701250047707898 0.742229260430374 0.7922547415581167 0.6785032563873821 1.0402481928829077 1.0204734724868778 0.7557903245536808 0.55343637445146 0.8524778397276928 1.0 12.217122675172932 QAISGT(ph)SPVASSFQGIK ddPTM_A459_Selumetinib_30min_R2 1 QAISGTSPVASSFQGIK 17 0 P51587;A0A590UJI7 P51587 BRCA2 Breast cancer type 2 susceptibility protein 1 QAISGT(0.435)S(0.435)PVAS(0.099)S(0.03)FQGIK 106.82 0.0058702 5259400.0 22295.0 18466.0 20331.0 24995.0 25073.0 20235.0 20991.0 22747.0 19749.0 21753.0 True False 21055.933153956394 19882.282822451543 19022.92559471908 21590.637881220013 21923.10558453602 23022.187574958767 21967.123092877424 22813.190004031436 23699.351833164637 21124.934368918424 0.9967336601498012 0.9411760754014356 0.9004963169356835 1.0220452051669702 1.0377833701955526 1.089811081677575 1.0398670457030215 1.0799176748021986 1.1218662940810842 1.0 14.366659238777029 -6.021039714381864 2.926206509186675 1.0658170663574946 0.9460809068728189 0.6338809777392138 0.03869804764347715 0.1585779182010643 2.7460599811986524 0.011691413848516827 0.01709434187768395 9.527090388535526e-07 6.021039714381864 -0.11973615948467575 QAISGTS(ph)PVASSFQGIK ddPTM_A459_Selumetinib_30min_R2 1 QAISGTSPVASSFQGIK 17 0 P51587;A0A590UJI7 P51587 BRCA2 Breast cancer type 2 susceptibility protein 1 QAISGT(0.211)S(0.788)PVASSFQGIK 214.24 1.0569e-09 3715900.0 26700.0 20494.0 28150.0 27101.0 30968.0 24931.0 25660.0 28075.0 24955.0 26528.0 True False 25216.120888568526 22065.823901403757 26338.85964740261 23409.79704816735 27077.522982567374 28365.01894891508 26853.240844325403 28156.693601933563 29946.697300958207 25762.06771197847 0.978808113171906 0.8565237910287734 1.0223891941389451 0.9086924741402882 1.0510617115557561 1.10103813350845 1.0423558056188003 1.0929516185085437 1.1624337625288528 1.0 14.652960771064883 -6.385850854971526 4.38911446688332 1.082617665699021 0.9416308422773528 0.5763040969093891 0.05630771578604766 0.16050196621822743 5.005567939305087 0.017194669244144457 0.019558216429609098 4.112909420272218e-07 6.385850854971526 -0.14098682342166813 QALAPGLS(ph)PSQRPGGSSSACSR ddPTM_A459_Selumetinib_30min_R2 1 QALAPGLSPSQRPGGSSSACSR 22 1 Q9BWK5-3;Q9BWK5-2;Q9BWK5 Q9BWK5-3 MRI Modulator of retrovirus infection homolog 1 QALAPGLS(0.573)PS(0.414)QRPGGS(0.003)S(0.003)S(0.003)ACS(0.003)R 50.49800000000001 0.02841 8596200.0 7093.2 6999.8 7780.1 9183.7 9737.1 5900.2 6415.7 5390.7 6815.2 6571.7 True False 6698.988340329379 7536.662152095544 7279.536836332399 7932.86421723385 8513.838447221548 6712.898993317111 6714.042762468373 5406.386044521571 8178.430432598288 6381.957945672834 1.0496760394467188 1.1809325940804163 1.1406431847875385 1.243014179153684 1.334048033486995 1.0518557236605837 1.052034942822007 0.8471359558530575 1.281492373064526 1.0 12.639783386577784 -6.961845573891094 24.070637420849486 1.0352153954778787 1.189772010355129 0.2619849869898242 0.11971558118739371 143.70363715523712 90658.1829250819 0.04139545439985454 0.03650725098733047 1.0918284989991116e-07 6.961845573891094 0.15455661487725036 QALAPGLSPS(ph)QRPGGSSSACSR ddPTM_A459_Selumetinib_30min_R2 1 QALAPGLSPSQRPGGSSSACSR 22 1 Q9BWK5-3;Q9BWK5-2;Q9BWK5 Q9BWK5-3 MRI Modulator of retrovirus infection homolog 1 QALAPGLS(0.263)PS(0.726)QRPGGS(0.004)S(0.004)S(0.001)ACS(0.001)R 59.154 0.0097627 6044500.0 13015.0 13019.0 14582.0 17747.0 18269.0 12524.0 13489.0 14616.0 13163.0 12758.0 True False 12291.678403173013 14017.515437317052 13643.809995681158 15329.827984717394 15973.884893067792 14249.067318447427 14116.265227946424 14658.530140190944 15795.967804949434 12389.64339073512 0.9920929937632131 1.131389741838675 1.1012270139981506 1.2373098644776912 1.28929335488485 1.1500788900108916 1.139360091550533 1.1831276880133998 1.2749332088735934 1.0 13.596847042748546 -4.553464092879591 1.2089604989926988 1.1864899565401694 0.8235843375531595 0.3098820945333468 0.0805444046701332 2.760268972087679 2.4207699583893976 0.023722947438864196 1.4338236746791724 2.7959918883976624e-05 4.553464092879591 -0.3629056189870099 QALDS(ph)EEEEEDVAAK ddPTM_A459_Selumetinib_30min_R1 1 QALDSEEEEEDVAAK 15 0 H7C3D5;Q8NC44 H7C3D5 FAM134A Protein FAM134A 1 QALDS(1)EEEEEDVAAK 200.33 1.9269e-05 10249000.0 3024.9 3442.0 3528.6 3007.8 2845.9 3853.0 3482.7 3852.6 2039.1 2956.8 True False 3095.3742845692027 3039.009039857614 3049.4355012123888 2482.5441933986845 2588.4888474844543 3814.242318244094 3219.9971350621418 3750.416532991532 3460.203770028466 3336.3340816709615 0.9277770777136691 0.9108827130212224 0.9140078381134772 0.7440934069034636 0.7758482166714077 1.1432435196459036 0.9651303065697324 1.124113005827397 1.0371274834369901 1.0 11.704048044019563 -6.760033998145519 24.99996685019192 1.0561303953568473 0.854822868162071 0.6459509970743054 0.07380314707661455 25.163111321943923 447623.05716664426 0.026161076233908086 0.024820622127038516 1.7376647927291072e-07 6.760033998145519 -0.2013075271947763 QALDS(ph)EEEEEDVAAK ddPTM_A459_Selumetinib_30min_R2 3 QALDSEEEEEDVAAK 15 0 H7C3D5;Q8NC44 H7C3D5 FAM134A Protein FAM134A 1 QALDS(1)EEEEEDVAAK;QALDS(1)EEEEEDVAAK;QALDS(1)EEEEEDVAAK 183.88 2.0985e-05 50729700.0 221694.0 103223.0 187110.0 214679.0 167226.0 152909.0 258599.0 209447.0 165115.0 160326.0 True False 209373.1349913975 111139.87218574234 175071.5463099644 185439.34985806904 146217.57486059194 173970.82678030018 270624.36590419745 210056.4560941827 198142.613698566 155696.97180302514 1.3447476374574514 0.7138216684544595 1.1244377092410658 1.1910273379797744 0.9391163692353263 1.117368082151229 1.7381479085320226 1.3491364261080727 1.2726170034266278 1.0 17.248381359719254 -7.023942597042868 24.845341071941423 1.377454068318118 1.0512611352424859 0.24451906073634 0.2284359627501142 841.9057630651155 873647.0023598659 0.0832672403422688 0.06489125582808511 9.463622387114638e-08 7.023942597042868 -0.32619293307563213 QALDYVELSPLTQAS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 QALDYVELSPLTQASPQR 18 0 F6TR96;Q9H2D6-6;Q9H2D6-5;Q9H2D6-7;Q9H2D6-3;Q9H2D6;F6WYE2;H0Y5J9;Q9H2D6-2 F6TR96 TRIOBP TRIO and F-actin-binding protein 1 QALDYVELSPLT(0.034)QAS(0.966)PQR 109.84 0.0015652 0.0 905.74 1035.9 1196.9 1308.5 1070.4 966.97 932.86 1030.7 585.04 1026.8 True False 926.8419797367542 914.6163464231554 1034.3675541010898 1079.9950385870668 973.5825089944694 957.2431597385129 862.4936191501055 1003.3624878145589 992.7701503690134 1158.5997818789722 0.799967334909763 0.7894152585976376 0.8927738208474307 0.9321553960899015 0.8403095911303825 0.8262069221056585 0.7444275690707854 0.8660130128691588 0.8568706518820307 1.0 10.178166583178925 -8.91080990483671 1.8622568942454607 0.999908456876049 0.836911106246065 0.48550069338736557 0.05027675003818902 2.066174438214951 8.792917656955462 0.052927266531627104 0.014764482204641948 1.227976611539183e-09 8.91080990483671 -0.162997350629984 QALYLMFDTSQES(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 QALYLMFDTSQESPVK 16 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 QALYLMFDTSQES(1)PVK 210.2 4.8075e-08 18250000.0 2935.2 2994.1 2861.0 2843.2 2621.6 2705.2 2472.8 2515.6 1890.3 3062.0 True False 3003.584449095016 2643.5493800806744 2472.4919143480806 2346.6884934740146 2384.476742881072 2677.988144125075 2286.274705137299 2448.878116179592 3207.701037950474 3455.03752640574 0.8693348266522684 0.7651289920520044 0.7156194094714227 0.6792078162795714 0.6901449621479603 0.7750966881424799 0.6617221050897528 0.7087848098504298 0.9284127924617452 1.0 11.754485664990657 -8.371473165015637 3.763982547580634 0.9948612254993066 0.7293150518326086 0.7261821544632451 0.0573428175970233 0.11942247824659667 2.8467615874529124 0.05713559775697946 0.015194328750773999 4.251349750129974e-09 8.371473165015637 -0.26554617366669797 QALYLMFDTSQESPVKSS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 QALYLMFDTSQESPVKSSPVR 21 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 QALYLMFDTSQES(0.046)PVKS(0.251)S(0.703)PVR;QALYLMFDT(0.001)S(0.01)QES(0.166)PVKS(0.407)S(0.416)PVR 87.80799999999998 0.00051079 28071000.0 3163.8 3375.5 3695.9 4435.9 3475.0 2971.8 3800.3 3957.2 2184.77 2932.8 True False 3237.510384316851 2980.294890772622 3194.017080125509 3661.2533371558025 3160.6868635610795 2941.90639017851 3513.640311360916 3852.242201202845 3707.3951207126174 3309.2534478911653 0.9783204687389438 0.9005943297186338 0.9651775333681102 1.106368368215783 0.9551057098921328 0.888993979005522 1.0617622272479603 1.1640819483493177 1.1203116289189543 1.0 11.692290073143392 -7.483824967586107 7.892438121304229 1.1080266085054837 0.9690217077209978 0.43798128070740316 0.06724098913188463 0.2480144071171912 45.627823844859776 0.029611436493488484 0.019547632240662777 3.2822755103365026e-08 7.483824967586107 -0.1390049007844859 QAPFRS(ph)PTAPSVFSPTGNR ddPTM_A459_Selumetinib_30min_R2 2 QAPFRSPTAPSVFSPTGNR 19 1 H0Y3X6;A0A0C4DFX9;Q9H3P2;C9JEM7;H7C2C7;C9JHL4 H0Y3X6 NELFA Negative elongation factor A 1 QAPFRS(0.998)PT(0.002)APSVFSPTGNR;QAPFRS(0.994)PT(0.006)APSVFSPTGNR 124.45 0.004640600000000001 16130000.0 53617.4 46685.8 60724.6 66176.7 61893.5 51089.5 51416.2 52943.8 37506.5 55020.3 True False 50637.55955545821 50266.450741492925 56817.645347945465 57163.31929882498 54117.885195089584 58126.61488069464 53807.1551792675 53097.85769268206 45008.84801917008 53431.72097909262 0.9477059437271776 0.9407604662623867 1.0633691804570122 1.069838632395773 1.0128418887399389 1.087867166087334 1.0070264291191704 0.9937515902483994 0.8423619377107778 1.0 15.705408865136434 -8.05000254746322 8.702464495136773 0.9197057763023381 1.0201834078467384 0.3075030989358941 0.057559008116790815 0.4783359130212812 78.30167052356784 0.03946536758796633 0.015014759170307715 8.91245710293142e-09 8.05000254746322 0.10047763154440037 QAPGVGAVGGGS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 QAPGVGAVGGGSPER 15 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 QAPGVGAVGGGS(1)PER 119.04 0.0019539 7380400.0 1604.3 1761.6 1512.1 1417.7 1734.9 1562.0 1536.6 1910.6 1073.0 1864.5 True False 1641.6770685756132 1555.3510530543774 1306.765125370757 1170.1253085249405 1577.978601321472 1546.2876981825261 1420.6930248762428 1859.9246814965531 1820.8026311806902 2103.826736767961 0.7803290260954032 0.7392961720050253 0.6211372365094555 0.5561890093300007 0.7500515958579689 0.7349881390698725 0.6752899371641251 0.8840674229446734 0.8654717612239916 1.0 11.03880017926451 -8.093280330471597 1.0274496743807724 0.9898598159935206 0.6828195805913795 0.6825207487285077 0.06984917878111885 0.301905040834286 0.6090956467538887 0.0685919355264153 0.024410138985268122 8.067141404663248e-09 8.093280330471597 -0.3070402354021411 QAPGVGAVGGGS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 QAPGVGAVGGGSPER 15 0 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 QAPGVGAVGGGS(1)PER;QAPGVGAVGGGS(1)PER 122.97 0.0014965 22440000.0 65417.0 53017.0 69101.0 86739.0 79379.0 59034.0 89054.0 105544.0 92377.0 65482.0 True False 61781.385024999574 57083.23342347628 64655.11689148012 74924.99856687916 69406.70036273624 67165.39764270408 93195.18745715333 105851.11556625013 110854.98122903715 63591.36451733169 0.9715373383466428 0.8976569988196804 1.016727937546591 1.1782259924059109 1.091448514897327 1.0562031205415996 1.4655321231824359 1.6645517260036247 1.743239543143061 1.0 15.956543245469707 -7.286247989883597 3.9671428367570205 1.5339986557483185 1.0339330751927691 0.5264579907388358 0.19835148259109944 0.159134867760268 5.723289408893802 0.08324344009251453 0.05699883449792613 5.173113536010975e-08 7.286247989883597 -0.5000655805555494 QAPGVGAVGGGS(ph)PEREEVGAGY(ph)NSEDEYEAAAAR ddPTM_A459_Selumetinib_30min_R1 1 QAPGVGAVGGGSPEREEVGAGYNSEDEYEAAAAR 34 1 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 2 QAPGVGAVGGGS(0.968)PEREEVGAGY(0.68)NS(0.349)EDEY(0.004)EAAAAR 71.098 0.00026552 15655000.0 941.97 973.26 1258.9 1026.0 1222.4 1088.1 956.58 1049.0 744.0 899.51 True False 963.9160682454461 859.3102667437016 1087.948294642712 846.8283604052958 1111.8341358322484 1077.1547019157535 884.4244004530233 1021.1771123677821 1262.5136603899657 1014.9708704693745 0.9496982586304984 0.8466353978674408 1.0719010035623868 0.8343376002640145 1.0954345274146433 1.0612666168612523 0.8713790968641495 1.0061146995238766 1.2438915215429924 1.0 9.98722260750857 -6.150684990774431 0.4391090360703907 1.066214644357986 0.8860158123767103 0.17159921414815804 0.11055885279201297 3.333162435373172 1.1210659334329827 0.10071577099308213 0.27833737214283827 7.068300573383833e-07 6.150684990774431 -0.18019883198127573 QAPGVGAVGGGS(ph)PEREEVGAGYNS(ph)EDEYEAAAAR ddPTM_A459_Selumetinib_30min_R1 1 QAPGVGAVGGGSPEREEVGAGYNSEDEYEAAAAR 34 1 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 2 QAPGVGAVGGGS(0.749)PEREEVGAGY(0.585)NS(0.637)EDEY(0.029)EAAAAR 61.869 0.00072307 15358000.0 1467.1 1394.1 1577.7 1786.6 1645.5 1407.7 1403.0 1509.3 847.75 1339.3 True False 1501.2805755203403 1230.8781239004936 1363.4570056857626 1474.6038486355774 1496.664815536621 1393.5398160893355 1297.1705804382195 1469.2684611026632 1438.5698327897755 1511.212200886742 0.9934280405090866 0.8144972116941914 0.9022273674641587 0.9757755051013459 0.990373697789374 0.922133777950999 0.8583642850931669 0.9722449701243364 0.9519310603406049 1.0 10.561490539256262 -14.522878745219037 0.1234933866381358 1.2427719663672756 0.8950685497657629 0.13047487993403406 0.0556210167272185 316.5228004177635 2.501345983660468 18.952973453137304 0.5139944438389927 3.0000000004234485e-15 14.522878745219037 -0.3477034166015127 QAPGVGAVGGGS(ph)PEREEVGAGYNS(ph)EDEYEAAAAR ddPTM_A459_Selumetinib_30min_R2 2 QAPGVGAVGGGSPEREEVGAGYNSEDEYEAAAAR 34 1 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 2 QAPGVGAVGGGS(0.999)PEREEVGAGY(0.463)NS(0.538)EDEYEAAAAR;QAPGVGAVGGGS(0.992)PEREEVGAGY(0.453)NS(0.512)EDEY(0.044)EAAAAR 75.225 1.8056e-05 42437000.0 67019.0 59687.0 73578.0 81457.0 81687.0 62068.0 65615.0 65899.0 59644.0 69235.0 True False 63294.35227831372 64264.80097604595 68844.07158566931 70362.41607883711 71424.7487689544 70617.30360279424 68666.2275136559 66090.75517983333 71574.46659260063 67236.00565586655 0.9413758545127241 0.955809321942352 1.0239167379756808 1.046499050508331 1.0622991070368912 1.0502899884361685 1.021271666034262 0.9829667086130168 1.0645258577515682 1.0 16.036946399310295 -5.25174808451535 3.474597487778909 1.0335668081273497 0.9442579436570739 0.6465800608239864 0.02467067741904042 0.14358647541631167 3.711809123690345 0.0067951282789102865 0.01907316767108586 5.6008238690829625e-06 5.25174808451535 -0.08930886447027575 QAPGVGAVGGGSPEREEVGAGYNS(ph)EDEYEAAAAR ddPTM_A459_Selumetinib_30min_R1 2 QAPGVGAVGGGSPEREEVGAGYNSEDEYEAAAAR 34 1 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 QAPGVGAVGGGS(0.007)PEREEVGAGY(0.463)NS(0.526)EDEY(0.003)EAAAAR;QAPGVGAVGGGSPEREEVGAGY(0.046)NS(0.952)EDEY(0.003)EAAAAR 111.01 1.4128999999999999e-14 9913500.0 334.14 318.89 402.18 530.35 306.34000000000003 357.77 160.85 308.21 167.23 0.0 True False 341.9248118767405 281.5542105520612 347.56616501660665 437.73432840248404 278.63160108871983 354.17115862916916 148.7169549989221 300.0352695928255 283.7770960040511 0.0 0.0 QAPLPS(ph)PESLDLGR ddPTM_A459_Selumetinib_30min_R2 1 QAPLPSPESLDLGR 14 0 H3BRS1;Q12968 H3BRS1 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 1 QAPLPS(0.997)PES(0.003)LDLGR 104.16 0.006381 2606000.0 15426.0 12379.0 22189.0 17186.0 22380.0 11518.0 11728.0 14485.0 12202.0 15001.0 True False 14568.684675170722 13328.42949524139 20761.383897556538 14845.237152496373 19568.424320261493 13104.499950006182 12273.375238591116 14527.148951879157 14642.740952365939 14567.88215272124 1.0000550884775885 0.9149188163052016 1.4251477105529968 1.0190388003463717 1.343258005186853 0.8995473612860259 0.8424955055185206 0.9972039037373408 1.0051386192488325 1.0 13.830503536303285 -6.8038342830282055 24.99979861855179 0.9420533082107412 1.1370206841814792 0.28488412708471755 0.15154452962603443 192.37099988091663 113437.71292931617 0.05356625152305069 0.04724135015159604 1.5709621336728886e-07 6.8038342830282055 0.194967375970738 QAPPHIELSNSS(ph)PDPMAEAER ddPTM_A459_Selumetinib_30min_R1 1 QAPPHIELSNSSPDPMAEAER 21 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 QAPPHIELS(0.001)NS(0.233)S(0.767)PDPMAEAER 110.36 7.2653e-05 8968200.0 3522.7 3008.7 2787.7 2385.4 3716.3 3032.3 4332.6 4217.8 1344.7 2902.7 True False 3604.772056019018 2656.4400052933174 2409.1456517400024 1968.8346695036962 3380.161321166057 3001.7978151081143 4005.788493803728 4105.9302426547465 2281.8576869978324 3275.289819692339 1.1005963607695726 0.8110549452209538 0.7355519005540411 0.6011176958039813 1.032018999003749 0.9164983804059469 1.2230332930293197 1.253608220551436 0.6966887856086508 1.0 11.67740685632996 -6.384333311099722 11.139304316702901 1.0385826007173462 0.8066016383132494 0.2269914777084191 0.18635237260653598 0.6935175353809365 59.85382335777566 0.05904115565006981 0.06693852766486699 4.1273061907819913e-07 6.384333311099722 -0.23198096240409682 QAPPHIELSNSS(ph)PDPMAEAER ddPTM_A459_Selumetinib_30min_R2 2 QAPPHIELSNSSPDPMAEAER 21 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 QAPPHIELSNS(0.234)S(0.766)PDPMAEAER;QAPPHIELS(0.02)NS(0.332)S(0.648)PDPMAEAER 187.73 2.8757e-17 10706000.0 23318.3 19853.5 27251.7 28790.9 40012.7 25900.9 24880.3 22861.5 24211.4 26438.7 True False 22022.362236550853 21376.19961093587 25498.355291407497 24869.529752927276 34985.94690792346 29468.51387003953 26037.28324937914 22928.023180074928 29054.356523038252 25675.34603500773 0.8577240675363783 0.8325574105910754 0.9931065877998719 0.9686151734437486 1.3626280580686605 1.1477358018801345 1.0140966830156024 0.8929976308328272 1.1316052560079743 1.0 14.648096099895277 -5.546265317769133 2.0356109808426366 1.0846149007926928 0.8440383678264146 0.3667199375874689 0.12004611584088212 0.3863587322613591 3.155743273034754 0.03819607719687111 0.095401201806248 2.842723909236543e-06 5.546265317769133 -0.24057653296627823 QAQAQES(ph)EEEEESR ddPTM_A459_Selumetinib_30min_R1 3 QAQAQESEEEEESR 14 0 H0YLQ7;Q9NVM6 H0YLQ7 DNAJC17 DnaJ homolog subfamily C member 17 1 QAQAQES(1)EEEEESR;QAQAQES(1)EEEEESR;QAQAQES(0.989)EEEEES(0.011)R 197.73 0.00010174 26760710.0 2029.22 1859.5700000000002 2450.56 2672.58 2345.05 1725.8200000000002 2330.1 2047.62 1356.491 2072.75 True False 2076.496877825222 1641.8506799093614 2117.787411962543 2205.8640735399476 2132.940641552205 1708.459817719186 2154.3386810257284 1993.3104659928667 2301.866152817266 2338.8076527947396 0.8878442292353236 0.702003295545679 0.9054987525083176 0.9431575405117509 0.9119777930448724 0.7304832510179602 0.9211269162948986 0.8522763569765885 0.9842049858468136 1.0 11.191557501730882 -8.291929867474439 4.350727428780336 0.9988685792283382 0.8554609384788082 0.3355860772871927 0.07617351658675198 0.24861134010481134 10.884718680677853 0.07035614968597723 0.019750887288876064 5.105874460976841e-09 8.291929867474439 -0.14340764074952994 QAQAQES(ph)EEEEESR ddPTM_A459_Selumetinib_30min_R2 2 QAQAQESEEEEESR 14 0 H0YLQ7;Q9NVM6 H0YLQ7 DNAJC17 DnaJ homolog subfamily C member 17 1 QAQAQES(1)EEEEESR;QAQAQES(1)EEEEESR 193.31 0.00011504 28901000.0 28960.0 25486.9 34504.0 35025.0 33438.0 24236.0 26914.0 29639.0 23196.0 28610.0 True False 27350.519136065344 27441.663276699877 32284.05020511473 30254.53457850492 29237.219500487205 27574.28900749693 28165.55432907924 29725.24458299941 27835.848150391757 27783.95496229283 0.9843997794116882 0.9876802389703878 1.1619674106486724 1.088921092031896 1.0523058916618127 0.992453703762461 1.0137345229397434 1.0698708885520873 1.001867739426203 1.0 14.761964356779679 -6.597436716867187 8.636194093119268 1.019946861695669 1.0599679398365853 0.12485878350885282 0.05117681049218378 0.6829810754115399 71.3767915237102 0.01828816186751863 0.01828215950847186 2.526755869029836e-07 6.597436716867187 0.040021078140916266 QAQEYEALLNIK ddPTM_A459_Selumetinib_30min_R2 2 QAQEYEALLNIK 12 0 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 165.7 0.0067414 24425300.0 54573.0 41331.0 51254.0 63542.0 67184.0 41452.0 56192.0 58226.0 44314.0 52952.0 False True 51540.05113302814 44500.954799888656 47956.373441135795 54887.46998393607 58743.74528741954 47161.63673620906 58805.039342335636 58395.42802016682 53178.03823661242 51423.138174181375 1.0022735477257485 0.8653877686179755 0.9325835634281422 1.067369124731755 1.1423601781836354 0.9171287169690484 1.1435521329552107 1.1355866268287396 1.034126662135765 1.0 15.650130035037618 -5.756494706499946 6.801805055253759 1.069372607813983 0.9258338651688145 0.39185619683065764 0.07345421575258584 0.1281157794473127 28.786482675563633 0.02007434170217529 0.032734388947685635 1.751883787324465e-06 5.756494706499946 -0.14353874264516842 QAQIEVVPS(ph)ASALIIK ddPTM_A459_Selumetinib_30min_R2 2 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 1 QAQIEVVPS(0.855)AS(0.145)ALIIK;QAQIEVVPS(0.5)AS(0.5)ALIIK 132.9 0.00053262 4602200.0 72824.0 64822.0 67365.0 85513.0 79778.0 58387.0 66591.0 72957.0 67838.0 66857.0 True False 68776.73361756977 69793.63896441855 63030.80924146631 73865.9818818471 69755.57441563098 66429.27926558514 69687.61344756324 73169.29279131853 81407.49555208978 64926.66469465255 1.0592987325165082 1.074961100999954 0.9708000486071112 1.137683295903706 1.0743748311065815 1.0231432582899387 1.0733280967889116 1.126952895785279 1.2538376325804799 1.0 15.986523479072014 -7.765148140560098 4.051359759229351 1.145401293745407 1.057720789437065 0.15641733352621523 0.06984926757584807 0.3076737225460802 11.340773006579036 0.03696463998988906 0.018149466729351114 1.7173224978087304e-08 7.765148140560098 -0.08768050430834196 QAQIEVVPSAS(ph)ALIIK ddPTM_A459_Selumetinib_30min_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 1 QAQIEVVPS(0.38)AS(0.62)ALIIK 124.43 0.0012876 9637700.0 1460.4 1760.0 2119.8 2317.4 2379.8 1743.8 2061.5 1954.3 921.66 1821.1 True False 1494.4244785562696 1553.9383817981984 1831.9428032279152 1912.7095929856089 2164.547510187816 1726.258955243719 1905.9993952768293 1902.4656155389482 1563.9897046169579 2054.855924016164 0.7272648466932196 0.7562274141152754 0.891518856294036 0.9308241860807771 1.053381643398756 0.8400875871967654 0.927558654113132 0.9258389326978347 0.7611189117143452 1.0 11.004821527720296 -5.26527937714704 3.0801242217804505 0.9190860402624623 0.7313432034116284 0.4703084011225407 0.0748941397949227 0.2204505310354987 4.238860946863136 0.0200713119285728 0.058172719333256566 5.429009765548548e-06 5.26527937714704 -0.18774283685083393 QAQQERDELADEIANSSGK ddPTM_A459_Selumetinib_30min_R1 2 QAQQERDELADEIANSSGK 19 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ; 180.1 1.4559e-12 10430300.0 2308.1 2257.2 2458.6 2746.2 2818.0 2481.3999999999996 2288.2 2333.3 1577.26 2154.3 False True 2361.8742392192053 1992.925974656188 2124.7356241231028 2266.627722558504 2563.1123975583077 2456.4393689309336 2115.599231759611 2271.4133043734455 2676.495021487469 2430.8253896590086 0.9716346757224402 0.8198556684220546 0.8740799043657992 0.9324518874128027 1.0544206130403535 1.0105371530924803 0.870321348772971 0.9344205939415808 1.1010642857662938 1.0 11.247230550500813 -5.995571365888905 5.3416879282091925 0.9871902032785701 0.8838869065810611 0.3295944046137228 0.0682515844088355 0.2136482438069693 19.701571659803484 0.0205022471970936 0.029300516065621104 1.0102494765998003e-06 5.995571365888905 -0.10330329669750904 QAQYLGMSCDGPFKPDHYRY ddPTM_A459_Selumetinib_30min_R1 1 QAQYLGMSCDGPFKPDHYRY 20 2 P23526-2;P23526 P23526-2 AHCY Adenosylhomocysteinase 0 80.238 0.0021983000000000003 38536000.0 3798.4 2211.7 4737.1 4741.8 4271.3 3277.3 3124.8 3143.9 2006.3 2226.6 False True 3886.895329600203 1952.753135808564 4093.827839027716 3913.7336446099753 3884.961669159262 3244.333337550317 2889.0938202090865 3060.513559173564 3404.5445656456836 2512.405798920645 1.5470810214138386 0.777244319626824 1.6294453072773778 1.557763338347394 1.5463113764616692 1.291325365887993 1.1499312019779093 1.2181605218744487 1.355093419665052 1.0 11.294853789022188 -6.996640878277175 23.97063372954814 1.2020694371985596 1.3987813104406996 0.16768539434219587 0.23995271107950747 133.4381969834004 952194.4383464103 0.08717751841585845 0.07645512442949007 1.0077646533854938e-07 6.996640878277175 0.19671187324214 QAS(ph)CILNVQS(ph)RSGDT(ph)SGSSVARRAPK ddPTM_A459_Selumetinib_30min_R2 1 QASCILNVQSRSGDTSGSSVARRAPK 26 3 Q96QF7 Q96QF7 ACRC Acidic repeat-containing protein 3 QAS(0.995)CILNVQS(0.783)RS(0.213)GDT(0.309)S(0.314)GS(0.314)S(0.072)VARRAPK 44.052 0.034587 7647800.0 40758.0 12651.0 27006.0 26900.0 11352.0 10620.0 32432.0 18725.0 17557.0 20849.0 True False 38492.83352720136 13621.291020623552 25268.463361909566 23236.1735949117 9925.860271832373 12082.808601238556 33940.152262788804 18779.48664990937 21068.890583567347 20247.035197792484 1.9011590166741152 0.6727548447245585 1.2480080720492135 1.1476333876994058 0.49023771504652597 0.5967692792155532 1.6763023292659298 0.9275178546613521 1.0405913941348048 1.0 14.305423047122382 -4.749163665948275 24.995678211358076 0.9839348017346675 1.9011611253894398 0.41686167198377877 0.3275702782394447 605.4091735387798 1232652.7429205123 0.08352144505322417 1.4081466094943473 1.7817071960531554e-05 4.749163665948275 0.9172263236547723 QAS(ph)DTEEDDITDNQK ddPTM_A459_Selumetinib_30min_R2 2 QASDTEEDDITDNQK 15 0 Q6ZU65-2;Q6ZU65;C9J6Y5;H7C4P8 Q6ZU65-2 UBN2 Ubinuclein-2 1 QAS(0.921)DT(0.079)EEDDITDNQK;QAS(0.993)DT(0.007)EEDDITDNQK 235.02 1.3728999999999999e-14 9576200.0 41289.0 42117.0 38469.0 46242.0 45798.0 27747.0 31526.0 33282.0 27758.0 34636.0 True False 38994.322672962764 45347.23847250034 35993.9464218803 39943.75982810063 40044.44580068525 31568.89738781227 32992.02146758388 33378.845109868285 33310.375623321896 33635.968684864536 1.1593042863816605 1.348176973803214 1.0701028639640993 1.1875311278332372 1.1905245297336833 0.9385458074236345 0.980855398477927 0.992355695850319 0.9903200926189127 1.0 15.037717186603107 -6.754185146538059 24.996480293224185 0.9799651248531893 1.1929295041968984 0.7220023763450574 0.06536991145861312 88.48563936555543 304901.6742804987 0.021660462360130774 0.021236821387640558 1.7612250485255014e-07 6.754185146538059 0.21296437934370904 QAS(ph)EGPLK ddPTM_A459_Selumetinib_30min_R1 1 QASEGPLK 8 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 QAS(1)EGPLK 110.84 0.011854 11665000.0 1857.3 2568.7 3587.1 3052.3 3803.2 2858.9 4047.7 7976.4 1754.7 2797.7 True False 1900.5714763233093 2267.955409843767 3099.991522529884 2519.27310376714 3459.2012315094944 2830.142061673509 3742.378730178035 7764.839961001306 2977.5977417826243 3156.8120469057276 0.6020540494915523 0.7184321955647603 0.982000662842269 0.7980434268288173 1.0957894166997257 0.8965190260369106 1.185493046330165 2.4597093034450106 0.94322933945378 1.0 11.62425265140449 -7.527170747394767 24.994831534290093 1.5854018295870071 0.8731163602483666 0.30409162567852965 0.41042892766622674 125.56274836975807 731206.4371479122 0.18107142806095364 0.10508218796696688 2.9704979199576087e-08 7.527170747394767 -0.7122854693386406 QAS(ph)ESSSRPH ddPTM_A459_Selumetinib_30min_R2 1 QASESSSRPH 10 1 A0A2R8Y653;Q9BZX2-2;Q9BZX2 A0A2R8Y653 UCK2 Uridine-cytidine kinase 2 1 QAS(1)ESSSRPH 125.03 0.0020318 4082000.0 2323.7 2892.2 3841.8 4205.2 4809.4 7312.2 13331.0 43969.0 7812.8 16209.0 True False 2194.5580565081177 3114.0224401112496 3594.6227706355717 3632.444505625377 4205.200175418483 8319.3891764573 13950.917914875366 44096.94251054022 9375.578307871216 15741.004053960312 0.13941665023305702 0.19782870453729323 0.22836045009029732 0.23076320247255655 0.26714942458581525 0.5285170595178271 0.8862787829195321 2.8014059560225943 0.5956150113253033 1.0 13.942239946917722 -7.388400499647456 3.211561601377865 1.5603822784415926 0.25129763769314833 0.48376153489470375 0.5460472032459026 0.18950652269770502 3.6757324300628698 0.23829013995120266 0.15009901201009915 4.088834198549099e-08 7.388400499647456 -1.3090846407484442 QAS(ph)FLEAEGGAK ddPTM_A459_Selumetinib_30min_R1 1 QASFLEAEGGAK 12 0 Q8WYP3;Q8WYP3-2 Q8WYP3 RIN2 Ras and Rab interactor 2 1 QAS(1)FLEAEGGAK 84.759 0.043179 0.0 2214.0 2160.2 1965.8 2135.4 2492.4 1856.7 2174.9 1854.3 1239.4 1734.3 True False 2265.581892305931 1907.282779750265 1698.8551573664663 1762.4924764224852 2266.96286006896 1838.023283748717 2010.8455419779643 1805.1179403847257 2103.1712778055426 1956.9142985125657 1.1577317892909162 0.974637867994513 0.8681295643134459 0.9006487804612298 1.1584374756687401 0.9392456711802777 1.027559328227297 0.9224307583407106 1.0747385715379287 1.0 10.93436486034154 -4.760044631985013 24.943651127546012 0.9816854787347712 1.1577320091400125 0.2846041241588605 0.08195352400101244 45.74816165218265 817854.0537922055 0.0204007776131786 0.12458382463337259 1.737622245970969e-05 4.760044631985013 0.17604653040524132 QAS(ph)LDGLQQLR ddPTM_A459_Selumetinib_30min_R2 2 QASLDGLQQLR 11 0 Q3MII6 Q3MII6 TBC1D25 TBC1 domain family member 25 1 QAS(1)LDGLQQLR;QAS(1)LDGLQQLR 106.76 0.010937 19200200.0 29743.0 21126.9 35222.0 37557.0 31255.0 24300.8 20768.1 20036.2 30154.0 25960.0 True False 28090.003130662706 22747.26529630951 32955.85486681403 32441.671810561293 27328.467476754828 27648.01461930112 21733.857801209437 20094.502024828533 36185.64257315544 25210.4673478197 1.114219849363167 0.9022944708828169 1.3072290335650671 1.286833415778267 1.0840127277179692 1.0966879049821434 0.8620965847778727 0.7970697943672347 1.4353419979850122 1.0 14.621735242455633 -6.916471191862389 3.2605361307371146 1.0048352132850353 1.1439395127298142 0.06846372076419904 0.18985027696913379 0.6296640731363637 13.415925370333937 0.07343975309772388 0.0629896301328337 1.212073086780568e-07 6.916471191862389 0.13910429944477887 QAS(ph)LPVSGSVAGDFVK ddPTM_A459_Selumetinib_30min_R2 1 QASLPVSGSVAGDFVK 16 0 H0Y7R3;F8W9F9;H0Y7T5;Q9Y3S1-2;Q9Y3S1-4;Q9Y3S1;E9PCD1;H0Y7J9;H0Y493 H0Y7R3 WNK2 Serine/threonine-protein kinase WNK2 1 QAS(0.817)LPVS(0.179)GS(0.004)VAGDFVK 102.69 0.0048052 1626700.0 7229.1 6206.3 9021.5 8235.4 8279.5 4565.8 6232.4 7698.4 6399.3 6048.4 True False 6827.335562380178 6682.3032536001865 8441.066511866524 7113.724313142594 7239.3551903308735 5194.697505794254 6522.21894926631 7720.8010694612685 7679.338811381363 5873.766976369519 1.1623436186431835 1.1376520860434969 1.4370788875053078 1.211100873044758 1.232489341074508 0.8843894432129843 1.1103979738225143 1.3144547784279605 1.3073958913037844 1.0 12.520070316973726 -6.564734810808401 24.99945876436885 1.132869275864176 1.2414292374332727 0.135570728818583 0.141264678179414 347.91556092627474 207797.99555731672 0.049926017049661375 0.04992604822245603 2.724364353493737e-07 6.564734810808401 0.10855996156909664 QAS(ph)PAWK ddPTM_A459_Selumetinib_30min_R2 2 QASPAWK 7 0 A0A2R8Y7W8;A0A2R8Y6W5;Q16626 A0A2R8Y7W8 MEA1 Male-enhanced antigen 1 1 QAS(1)PAWK;QAS(1)PAWK 87.149 0.03397 14941500.0 139372.0 138171.0 143101.0 164655.0 161369.0 126861.0 127000.0 133218.0 114308.0 151083.0 True False 131626.26219032102 148768.2714102105 133894.037456588 142228.70495428183 141096.38356283642 144334.95122050127 132905.7516457258 133605.64232457298 137172.79403237568 146720.8412292232 0.8971204164831648 1.0139545967964332 0.9125768114115719 0.9693831071488795 0.9616655846622386 0.9837385746378428 0.9058409870898029 0.9106112070052799 0.9349237155617821 1.0 17.162714290250065 -9.580633336163151 9.84677733920277 0.9999999999999999 0.9449181138569792 0.17758130339619382 0.03645069441941041 0.0 0.0 0.034625530836314825 0.00839792476360044 2.6264350402025987e-10 9.580633336163151 -0.055081886143020675 QAS(ph)PTEVVER ddPTM_A459_Selumetinib_30min_R1 2 QASPTEVVER 10 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 QAS(0.5)PT(0.5)EVVER;QAS(0.718)PT(0.282)EVVER 137.09 0.0017840999999999996 89224000.0 5856.1 6328.7 7614.9 7329.3 7541.9 5397.5 5992.3 5769.6 3392.8 4767.5 True False 5992.535736012996 5587.732861867192 6580.838405651594 6049.375343000524 6859.736476630594 5343.206050537891 5540.295986571591 5616.571465697952 5757.33379969231 5379.455064382549 1.113967058799257 1.0387172668963542 1.2233280744779191 1.1245331117371957 1.2751731159628064 0.9932615825560729 1.029899110646722 1.044078145179677 1.0702447981788532 1.0 12.393244320690988 -6.7933401321341975 24.999863087871628 1.0304017258871916 1.1507631780894925 0.5073608009050506 0.06278394906790268 179.7566101687553 140869.7936905874 0.022452340264255577 0.0198027681352029 1.6093846984415514e-07 6.7933401321341975 0.12036145220230088 QAS(ph)TDAGTAGALTPQHVR ddPTM_A459_Selumetinib_30min_R1 2 QASTDAGTAGALTPQHVR 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 QAS(0.5)T(0.5)DAGTAGALTPQHVR;QAS(0.751)T(0.249)DAGTAGALTPQHVR 152.57 6.0396e-05 140636000.0 2970.1 3153.2 3349.4 3855.3999999999996 4021.5 3273.7 3691.6000000000004 3115.7 1700.1 3048.1 True False 3039.2975511914383 2784.0218781170884 2894.5698769372484 3182.1267648212256 3657.75603505349 3240.769550281777 3413.1396398757897 3033.061514780074 2884.9455296088454 3439.3533260082754 0.8836828505546003 0.8094608533134434 0.8416029417648392 0.9252107774906663 1.0635010969631007 0.9422613041164412 0.9923783096274934 0.8818697084257566 0.8388046403354327 1.0 11.747921616722222 -5.824528625411421 4.5732032825432425 0.952073176130052 0.8408651052965623 0.3848368563771648 0.060975471768787357 0.220006341988103 9.062613103924694 0.018398813051491845 0.028690601868877466 1.4978605221409042e-06 5.824528625411421 -0.11120807083348971 QAS(ph)TDAGTAGALTPQHVR ddPTM_A459_Selumetinib_30min_R2 6 QASTDAGTAGALTPQHVR 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 QAS(0.715)T(0.284)DAGT(0.001)AGALTPQHVR;QAS(0.745)T(0.254)DAGT(0.001)AGALTPQHVR;QAS(0.748)T(0.252)DAGTAGALTPQHVR;QAS(0.493)T(0.493)DAGT(0.013)AGALT(0.001)PQHVR;QAS(0.754)T(0.246)DAGTAGALTPQHVR;QAS(0.5)T(0.5)DAGTAGALTPQHVR 228.19 1.031e-18 320809100.0 132229.0 112680.0 140600.0 140925.0 145457.0 97094.0 110960.0 104497.0 92317.0 109749.4 True False 124880.24153462645 121322.19367669418 131553.94907370565 121730.77189081543 127183.39125792128 110467.81716842337 116119.85986306891 104801.06896959043 110782.97955249678 106580.64965881387 1.1716971320253091 1.1383135124909725 1.2343136347436081 1.1421470246287686 1.1933065867496673 1.0364716064506372 1.0895022711420128 0.9833029663928655 1.039428638379813 1.0 16.701586006573955 -6.766880030867546 24.92842528457157 1.0324325741880447 1.1752282200358755 0.8033296846945279 0.03615970824579714 55.90274542274943 256138.05247449252 0.012287409385964839 0.011146589737219678 1.7104877534934714e-07 6.766880030867546 0.14279564584783078 QAS(ph)VHDSGEEGEA ddPTM_A459_Selumetinib_30min_R1 2 QASVHDSGEEGEA 13 0 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-3 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 QAS(1)VHDSGEEGEA;QAS(1)VHDSGEEGEA 102.5 0.0092472 4139300.0 2860.3 2601.1 2365.5 3420.6000000000004 4618.9 2564.3 3848.2999999999997 2469.1 468.42999999999995 1415.74 True False 2926.9394248250483 2296.5620027814152 2044.2780927614083 2823.256422614383 4201.121310533027 2538.5054701981107 3558.019632715897 2403.6114472328795 794.89149722644 1597.464019475396 1.832241220547959 1.4376298775953662 1.279702120259801 1.7673364709281745 2.629869129642536 1.5890845986200997 2.2272925019521526 1.504641993765982 0.49759586916234944 1.0 10.641567721619023 -8.102751798991273 4.68018832041202 0.7703649591503745 1.811370881363794 0.551669892804451 0.38136499706591775 0.17942511194965877 6.194795812369491 0.2885495634655186 0.10356393942613581 7.893110831380725e-09 8.102751798991273 1.0410059222134196 QASASYDS(ph)EEEEEGLPMSYDEKR ddPTM_A459_Selumetinib_30min_R1 2 QASASYDSEEEEEGLPMSYDEKR 23 1 Q15059 Q15059 BRD3 Bromodomain-containing protein 3 1 QAS(0.008)AS(0.023)YDS(0.968)EEEEEGLPMSYDEKR;QAS(0.011)AS(0.022)Y(0.002)DS(0.965)EEEEEGLPMSYDEKR 156.9 9.7261e-10 39456000.0 1219.8000000000002 1570.14 2248.5 2381.3999999999996 2226.19 1572.42 1935.1100000000001 1762.87 982.8 1184.44 True False 1248.2189666823733 1386.3072788617167 1943.166050126411 1965.533194414397 2024.831507565766 1556.6028824431285 1789.1430947340002 1716.112960991222 1667.7398191280363 1336.474411422604 0.933963984655503 1.037286809992919 1.4539493113512116 1.4706852429162445 1.5150544524159228 1.1647083319658997 1.3387035916606553 1.2840597218502026 1.247865132975362 1.0 10.384216500195103 -5.1225013795026415 4.9475611003120425 1.327677810021368 0.9579404413569345 0.439228149946328 0.1467808577885437 0.182090377556268 6.42276012657174 0.037601047565086726 0.10831262091068058 7.542210001194237e-06 5.1225013795026415 -0.3697373686644335 QASASYDS(ph)EEEEEGLPMSYDEKR ddPTM_A459_Selumetinib_30min_R2 4 QASASYDSEEEEEGLPMSYDEKR 23 1 Q15059 Q15059 BRD3 Bromodomain-containing protein 3 1 QAS(0.006)AS(0.043)Y(0.008)DS(0.943)EEEEEGLPMSYDEKR;QAS(0.154)AS(0.29)Y(0.008)DS(0.548)EEEEEGLPMSYDEKR;QASAS(0.003)YDS(0.997)EEEEEGLPMSYDEKR;QAS(0.015)AS(0.037)YDS(0.948)EEEEEGLPMSYDEKR 125.12 5.2495e-06 67048000.0 64928.3 63017.2 68280.6 67605.8 74158.0 44177.1 38820.8 49049.8 33121.7 65782.3 True False 61319.84501457849 67850.41660776525 63887.50053429627 58397.77341348998 64841.609059068425 50262.09452521426 40626.044121955856 49192.526797368475 39746.965497621626 63882.99407605848 0.9598774431513286 1.062104517627699 1.0000705423767775 0.914136449897169 1.0150057929637522 0.7867836386217699 0.6359445844630713 0.770041033749926 0.6221838232926163 1.0 15.963144310292579 -6.837276565868729 4.63750926006381 0.7350230503100388 0.9907848249151483 0.5424190958275352 0.1035757958479573 0.14407236344963192 5.750408515407256 0.03489564649195411 0.031062235433793158 1.4545325153594465e-07 6.837276565868729 0.2557617746051095 QASPT(ph)EVVER ddPTM_A459_Selumetinib_30min_R1 2 QASPTEVVER 10 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 QAS(0.112)PT(0.888)EVVER;QAS(0.328)PT(0.672)EVVER 111.31 0.020872 179319000.0 4780.2 4916.4 5058.5 5434.6 5947.2 4263.5 5291.5 4253.4 2287.6 3665.8999999999996 True False 4891.569359349958 4340.785602427647 4371.583484351544 4485.549130076633 5409.2768100634385 4220.613060948272 4892.357894788907 4140.586015009649 3881.8901203065675 4136.453973889877 1.1825513810201977 1.0493977764112818 1.056843255586996 1.084394787997235 1.3077086906340247 1.020345708568166 1.182742011798136 1.0009989331794464 0.9384584344005356 1.0 12.014178814110462 -7.890329218606962 5.8425653352752445 0.9696746969125338 1.1215897854681545 0.4107177317448314 0.08072892635251525 0.20723773200434145 9.751050261307887 0.04492037125578629 0.02116363588193556 1.2872733592020339e-08 7.890329218606962 0.15191508855562064 QASPT(ph)EVVER ddPTM_A459_Selumetinib_30min_R2 1 QASPTEVVER 10 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59;A0A0C4DG68 Q8TB72-3 PUM2 Pumilio homolog 2 1 QAS(0.027)PT(0.973)EVVER 123.95 0.0093421 240950000.0 63048.0 62105.0 58064.0 77509.0 94511.0 52553.0 48283.0 48797.0 53404.0 61359.0 True False 59544.044561141185 66868.25380095051 54328.2254553032 66952.14048951706 82637.68324093978 59791.69872136434 50528.25517094946 48938.991191221794 64086.29223243328 59587.40624017217 0.9992723012836604 1.1221876906578592 0.911740061923968 1.1235954829055772 1.386831353388021 1.003428450642217 0.8479686960578713 0.8212975573054645 1.0755006179347355 1.0 15.862719829788682 -6.9955156208303 24.99967847048342 0.9219282077122203 1.1089331774480389 0.27544655130812057 0.13183509441048347 165.2302454485189 921123.1180758495 0.048569576446060955 0.04267053835330634 1.0103791582630586e-07 6.9955156208303 0.1870049697358186 QASQLS(ph)LESTVGPCGER ddPTM_A459_Selumetinib_30min_R2 1 QASQLSLESTVGPCGER 17 0 Q9H426;Q9H426-2 Q9H426 RIMS4 Regulating synaptic membrane exocytosis protein 4 1 QAS(0.001)QLS(0.982)LES(0.008)T(0.008)VGPCGER 100.07 0.004534000000000001 4614300.0 8615.3 7726.5 10675.0 14094.0 11566.0 10843.0 8609.6 9014.1 6975.3 10675.0 True False 8136.496115778448 8319.097705386755 9988.182122061204 12174.37288649389 10112.9756786481 12336.524827046102 9009.96345959875 9040.329538635408 8370.554906166046 10366.785013019085 0.7848620479309895 0.8024761480959863 0.9634792377306547 1.1743633991835223 0.9755170639641663 1.1900048869107758 0.8691183861036593 0.8720475564297075 0.8074398085475794 1.0 13.339680928964349 -5.273880527558719 4.8244102753573985 0.9879918735550338 0.7903788176048272 0.2936364972315917 0.11672376934737025 0.23067809923463856 15.781302295236104 0.03298856608148918 0.07953500910946505 5.322546599705419e-06 5.273880527558719 -0.19761305595020662 QASSET(ph)PGCTDR ddPTM_A459_Selumetinib_30min_R2 1 QASSETPGCTDR 12 0 Q92609;Q92609-2 Q92609 TBC1D5 TBC1 domain family member 5 1 QAS(0.001)S(0.071)ET(0.927)PGCTDR 129.29 0.0048485 0.0 4477.1 5762.7 6138.0 8645.1 10305.0 6967.8 5884.4 6533.6 6300.8 7592.1 True False 4228.28070525132 6204.6805599989975 5743.087762549101 7467.62246637068 9010.39377213113 7927.55120260923 6158.036259717398 6552.611694304292 7561.136059061409 7372.896346355238 0.5734897802193508 0.8415526637732071 0.7789459518698068 1.0128478844087194 1.2220969004379645 1.0752288965147576 0.835226208321998 0.8887432274215478 1.0255313114227118 1.0 12.84801575929756 -4.991461348913009 1.1815377184854166 1.0019440300929359 0.5057018426619627 0.5752498464767002 0.11203502729829845 0.9239596275836671 1.4112526652246862 0.03943135657179971 0.5173767282455524 1.0198555205127008e-05 4.991461348913009 -0.49624218743097315 QASTDAGT(ph)AGALTPQHVR ddPTM_A459_Selumetinib_30min_R1 3 QASTDAGTAGALTPQHVR 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 QAS(0.001)T(0.001)DAGT(0.829)AGALT(0.169)PQHVR;QAS(0.13)T(0.319)DAGT(0.551)AGALTPQHVR;QAS(0.177)T(0.409)DAGT(0.412)AGALT(0.001)PQHVR 216.71 8.2702e-14 114282000.0 5328.700000000001 6748.9 7665.799999999999 7274.4 7053.299999999999 6630.400000000001 7197.1 6686.1 3909.5199999999995 5867.9 True False 5452.848342154749 5958.735650521508 6624.826465225281 6004.062597399889 6415.330260361252 6563.704195921522 6654.216952581548 6508.762908486397 6634.169899956696 6621.102123186228 0.8235559942595647 0.8999612964214524 1.0005624957854087 0.9068071275285805 0.968921811052515 0.9913310614763506 1.0050014074362872 0.9830331548117293 1.0019736558245653 1.0 12.692855667149706 -3.3332912160513244 0.5956084637429068 0.9920563963017692 9.992337824136104e-13 0.7804026990575701 0.02717931805168571 8.370083528060025 0.5811106331813577 0.012939652562999565 8.369587110732583 0.0004642038990346417 3.3332912160513244 -0.99205639630077 QASTDAGTAGALT(ph)PQHVR ddPTM_A459_Selumetinib_30min_R1 1 QASTDAGTAGALTPQHVR 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 QASTDAGTAGALT(1)PQHVR 129.66 0.00083992 7724300.0 1733.4 2026.1 2318.9 2013.3 2414.2 1687.3 2232.1 2133.1 1167.4 1899.8 True False 1773.784847390741 1788.8832700916635 2004.00611680593 1661.7149493216202 2195.836036261628 1670.3272939458243 2063.73089992598 2076.5232587146957 1980.9925364774822 2143.657835619081 0.8274570772991288 0.8345003761176466 0.9348535402932809 0.7751773262087429 1.0243407318908608 0.7791949191664906 0.9627146952442536 0.9686822328690357 0.9241178809235562 1.0 11.065858930079965 -5.045314803861221 0.1393130067468882 1.0445374610157663 0.6551418836420748 0.30140563924105424 0.07264341772269511 32.82677117223933 0.8527528222351028 0.45514944529612433 2.460950837693299 9.009178591338808e-06 5.045314803861221 -0.38939557737369146 QASTDAGTAGALT(ph)PQHVR ddPTM_A459_Selumetinib_30min_R2 3 QASTDAGTAGALTPQHVR 18 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8 P46937-6 YAP1 Transcriptional coactivator YAP1 1 QASTDAGTAGALT(1)PQHVR;QASTDAGTAGALT(1)PQHVR;QASTDAGTAGALT(1)PQHVR 146.75 0.00032092 22842500.0 88589.0 84292.0 97149.0 121665.0 117623.0 85317.0 99962.0 99256.0 79688.0 82421.0 True False 83665.57802986515 90756.92535850126 90898.5391078337 105094.01711616866 102846.1471770384 97068.64231938506 104610.43107094534 99544.81852728456 95627.82666875393 80041.2915745243 1.0452802095524205 1.13387632274774 1.135645581420941 1.312997517266678 1.2849136383722783 1.2127320837771223 1.3069558100964098 1.2436683188026902 1.1947311792153859 1.0 16.288456826817182 -5.592558149121684 6.092196778868149 1.2380283794825844 1.1000866563079663 0.2714191345014715 0.08717192908514648 0.2193653236647083 14.363291081466599 0.022401756136430497 0.039394642791340924 2.5552997406414477e-06 5.592558149121684 -0.13794172317461806 QATPGVPAQQS(ph)PSM ddPTM_A459_Selumetinib_30min_R2 2 QATPGVPAQQSPSM 14 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 QATPGVPAQQS(1)PSM;QATPGVPAQQS(0.998)PS(0.002)M 124.09 0.0015321 11416100.0 64746.0 55906.0 65616.0 76878.0 78353.0 51956.0 59890.0 67426.0 60946.0 68159.0 True False 61147.676518773704 60193.81043387715 61394.33799729904 66407.08377805288 68509.59565529264 59112.46739039079 62675.00366978367 67622.19849702482 73136.90297352019 66191.07257165048 0.9238054943524687 0.9093946977323654 0.9275320010994069 1.0032634492539545 1.0350277309849059 0.893058007579538 0.9468800131911937 1.0216211321220874 1.1049360605896057 1.0 16.014349028226583 -5.818318708983934 0.3139813840759003 1.0359764754651457 0.8683123758096534 0.3322791634891983 0.05215858609585156 5.172786983060804 0.6821462595270412 0.06792721721289134 0.31647265475892855 1.5194320783406857e-06 5.818318708983934 -0.16766409965549234 QATVSWDSGGSDEAPPKPS(ph)RPGYPSPR ddPTM_A459_Selumetinib_30min_R1 2 QATVSWDSGGSDEAPPKPSRPGYPSPR 27 2 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-6;B4DWJ1;E5RHK7;E5RG80;E5RJQ2;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 QATVSWDS(0.006)GGS(0.031)DEAPPKPS(0.416)RPGY(0.36)PS(0.186)PR;QATVSWDS(0.003)GGS(0.022)DEAPPKPS(0.814)RPGY(0.138)PS(0.022)PR 113.52 3.3105e-10 24309400.0 1968.34 2051.3 2208.23 2198.5 1921.0 1490.3899999999999 2145.45 2085.98 1037.42 1439.13 True False 2014.1984922770814 1811.1328423765017 1908.364494939135 1814.5732459561825 1747.2458891800961 1475.3980297658484 1983.616979188296 2030.6530341820253 1760.425969841074 1623.8563538132894 1.2403797217328705 1.1153282358525323 1.1752052393413601 1.1174468983632906 1.0759854990110744 0.9085766892503654 1.2215470749799904 1.250512725102475 1.084102030150068 1.0 10.665208302156204 -1.5228916941663684 0.944407077047943 1.1057961777805048 88.67748917703597 0.15654905800854035 0.0951000837025388 2664.360455067796 4.758592537101685 0.03278262546571273 503919.08916759474 0.029999105535976334 1.5228916941663684 87.57169299925546 QATVSWDSGGSDEAPPKPS(ph)RPGYPSPR ddPTM_A459_Selumetinib_30min_R2 4 QATVSWDSGGSDEAPPKPSRPGYPSPR 27 2 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-6;B4DWJ1;E5RHK7;E5RG80;E5RJQ2;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 QATVSWDSGGSDEAPPKPS(0.513)RPGY(0.432)PS(0.054)PR;QATVS(0.002)WDS(0.008)GGS(0.003)DEAPPKPS(0.596)RPGY(0.183)PS(0.208)PR;QATVSWDS(0.001)GGS(0.001)DEAPPKPS(0.348)RPGY(0.302)PS(0.348)PR;QATVS(0.002)WDS(0.115)GGS(0.091)DEAPPKPS(0.571)RPGY(0.176)PS(0.045)PR 68.771 0.00033176 137066000.0 141910.9 109715.1 139181.2 166163.3 165680.7 138381.3 170506.4 157036.0 116335.5 127273.0 True False 134024.0602923431 118129.89538035024 130226.43312103281 143531.5718923192 144866.4092617493 157442.06797463022 178435.28545202193 157492.9487612907 139605.85068545878 123598.29779503308 1.0843519909521684 0.9557566527028449 1.0536264288768067 1.161274665208918 1.1720744690350493 1.2738206818650635 1.4436710588678716 1.274232344384436 1.1295127293498128 1.0 16.915299348912313 -5.975402063089277 1.6084605855361382 1.2487298706284442 1.0148932145238887 0.33252130977751415 0.11309877341125374 0.3790457305258124 1.9843672605618552 0.03863778338661315 0.06727499885256637 1.0582735383134727e-06 5.975402063089277 -0.2338366561045555 QAVDVS(ph)PLRR ddPTM_A459_Selumetinib_30min_R2 1 QAVDVSPLRR 10 1 M0R0F0;M0R0R2;P46782;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 QAVDVS(1)PLRR 67.234 0.042831 8167700.0 48915.0 47212.0 52295.0 60203.0 65634.0 55575.0 43647.0 53714.0 44554.0 58539.0 True False 46196.50012225956 50833.0085894932 48930.39663449088 52003.24754403234 57388.470144595325 63229.95179037973 45676.67198488972 53870.29884716859 53466.044942772685 56848.82696741205 0.812620111734956 0.8941786717715855 0.8607107524406734 0.9147637747009734 1.0094926000406765 1.1122472558075047 0.8034760683993243 0.9476061639415907 0.9404951305929582 1.0 15.794842960052069 -5.949848668237728 3.659995939401948 0.9652177051146749 0.86011388661985 0.31510229248569654 0.07446152570935248 0.31693479367758043 8.827342414238412 0.022873686685369054 0.03448793615433685 1.1224094945379182e-06 5.949848668237728 -0.10510381849482486 QCEGITS(ph)PEGSK ddPTM_A459_Selumetinib_30min_R2 2 QCEGITSPEGSK 12 0 Q9Y570-2;Q9Y570;Q9Y570-4 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 1 QCEGIT(0.469)S(0.531)PEGSK;QCEGIT(0.47)S(0.528)PEGS(0.002)K 247.17 3.2191999999999998e-18 52022000.0 360370.0 325160.0 339100.0 365430.0 368360.0 288220.0 350370.0 323650.0 277980.0 337150.0 True False 340342.0780754098 350098.7264458112 317282.67518416414 315657.8035980885 322083.32361981756 327919.68879933824 366662.89924498403 324591.7679168582 333583.7674101523 327415.60347909946 1.0394803254913767 1.069279297399642 0.9690517855982934 0.9640890667516354 0.9837140325548892 1.0015395885684202 1.1198699614460796 0.9913753787778122 1.0188389431215565 1.0 18.320763551671938 QCT(ph)RVT(ph)T(ph)LT(ph)GKK ddPTM_A459_Selumetinib_30min_R1 1 QCTRVTTLTGKK 12 2 Q8WTR2-2;Q8WTR2 Q8WTR2-2 DUSP19 Dual specificity protein phosphatase 19 4 QCT(1)RVT(1)T(1)LT(1)GKK 65.495 0.033486 0.0 68.14 181.07 301.26 201.13 105.3 114.64 214.8 230.81 0.0 234.88 True False 69.72752942264052 159.87024022284078 260.35054670272734 166.0064211776971 95.77563359222493 113.4868256847918 198.59746306352793 224.68816902345824 0.0 265.02913592494446 0.2630938261911972 0.6032176034717768 0.982346887236043 0.6263704577171835 0.3613777528948679 0.42820509257869277 0.7493420010989668 0.8477866716023604 0.0 1.0 8.050007160559357 -10.76308074086613 3.6683398017865256 1.000707081463118 0.5642313925806488 0.19509889902091848 0.27632678901012925 303389938.9017699 548068334.9168757 2504419.441337024 0.0689897033173835 1.7255170666061756e-11 10.76308074086613 -0.43647568888246924 QDDGSSS(ph)ASPSVQGAPR ddPTM_A459_Selumetinib_30min_R1 1 QDDGSSSASPSVQGAPR 17 0 Q9NQA3 Q9NQA3 WASH6P WAS protein family homolog 6 1 QDDGSS(0.007)S(0.599)AS(0.36)PS(0.034)VQGAPR 194.1 8.8729e-08 11738000.0 1882.2 1881.6 2390.1 1916.0 2297.8 1815.7 2531.9 1987.0 1433.5 1553.3 True False 1926.0515978763428 1661.3013972678914 2065.5375478795345 1581.4065677744125 2089.964395709541 1797.4357065236948 2340.916744555616 1934.2983053143776 2432.5448013024425 1752.6811854232642 1.0989172553998807 0.947862857822996 1.1785015809254078 0.9022785095924393 1.192438426960591 1.0255348899004828 1.3356203992058575 1.1036224507923007 1.3878991921254602 1.0 10.775347876858122 -7.239033985739956 24.51297683374753 1.215420732210697 1.0571673503133732 0.23307304309578014 0.13221334901787646 823.1761470962252 900610.1962645543 0.04631628093933152 0.03584533231323251 5.7672133026506216e-08 7.239033985739956 -0.15825338189732374 QDDGSSSAS(ph)PSVQGAPR ddPTM_A459_Selumetinib_30min_R1 1 QDDGSSSASPSVQGAPR 17 0 Q9NQA3 Q9NQA3 WASH6P WAS protein family homolog 6 1 QDDGSSS(0.078)AS(0.916)PS(0.006)VQGAPR 265.93 3.2523e-41 13638000.0 2040.0 2196.2 2341.4 2460.5 2221.9 1649.4 1965.0 1980.7 1144.7 1897.0 True False 2087.5280308509946 1939.0678830143186 2023.4507403895836 2030.8198643052945 2020.929537308306 1632.808533535376 1816.7784679694228 1928.165401779663 1942.4722944198852 2140.4984283447716 0.975253241585074 0.9058954948702217 0.945317554824976 0.9487602688294003 0.9441396968794192 0.7628169738008228 0.8487642148722909 0.9008020637841327 0.9074859708829507 1.0 11.063731060902345 QDDGSSSAS(ph)PSVQGAPR ddPTM_A459_Selumetinib_30min_R2 2 QDDGSSSASPSVQGAPR 17 0 Q9NQA3 Q9NQA3 WASH6P WAS protein family homolog 6 1 QDDGSS(0.002)S(0.06)AS(0.936)PS(0.002)VQGAPR;QDDGSSS(0.024)AS(0.944)PS(0.032)VQGAPR 269.0 1.5833e-51 31326000.0 38777.0 41023.0 39562.0 48745.0 51229.0 41624.0 37639.0 40392.0 32027.0 41111.0 True False 36621.92957663006 44169.332190264766 37016.62399184871 42105.84691018478 44793.15502692919 47357.32817494854 39389.28808026356 40509.534032744436 38433.29490914802 39924.01861079413 0.9172906648913518 1.1063348261821229 0.9271768043370424 1.0546495161386573 1.121960077806862 1.1861864066495722 0.9866062949287876 1.0146657436381417 0.9626609806948875 1.0 15.284969324124164 -4.741927122473113 24.77001111374577 1.0428739572206662 0.9172901854333628 0.1924644131486417 0.07521895166379096 2226.9136507889025 2826810.6034841146 0.019640490435432912 0.7355017441300148 1.8116440731401177e-05 4.741927122473113 -0.1255837717873034 QDDS(ph)PPRPIIGPALPPGFIK ddPTM_A459_Selumetinib_30min_R1 2 QDDSPPRPIIGPALPPGFIK 20 1 A0A0A0MRI1;Q8IXQ4-4;Q8IXQ4 A0A0A0MRI1 GPALPP1 GPALPP motifs-containing protein 1 1 QDDS(1)PPRPIIGPALPPGFIK;QDDS(1)PPRPIIGPALPPGFIK 75.797 0.0032644 84127000.0 8885.2 11172.1 11416.1 12054.900000000001 11386.7 9363.0 10491.400000000001 9418.0 6251.4 9856.1 True False 9092.207872410412 9864.065338231621 9865.8563241486 9949.73801349884 10356.774995485162 9268.816720923813 9700.025251325407 9168.204046024566 10608.169215808912 11121.226441543955 0.8175544235342577 0.8869584114737437 0.8871194535967859 0.8946619391123127 0.9312619475849226 0.8334347627613836 0.872208231916799 0.8243878581391199 0.9538668483703839 1.0 13.441028275845287 -8.46834933191743 4.9412515488478475 0.9995875258636955 0.8719330491855918 0.6368840189677657 0.033545482250669875 0.11529526856705709 5.841275365994736 0.03271301472131594 0.008515607606081093 3.4013448686204573e-09 8.46834933191743 -0.1276544766781037 QDDS(ph)PPRPIIGPALPPGFIK ddPTM_A459_Selumetinib_30min_R2 2 QDDSPPRPIIGPALPPGFIK 20 1 A0A0A0MRI1;Q8IXQ4-4;Q8IXQ4 A0A0A0MRI1 GPALPP1 GPALPP motifs-containing protein 1 1 QDDS(1)PPRPIIGPALPPGFIK;QDDS(1)PPRPIIGPALPPGFIK 81.22399999999998 0.0020828 27241000.0 109459.0 97600.0 112997.0 111680.0 124416.0 93641.0 99197.0 105225.0 92409.0 110352.0 True False 103375.70697909461 105085.60616653708 105726.89604183157 96468.99134125437 108785.74978684787 106539.19776163633 103809.85705512657 105531.18732906338 110893.3821231916 107165.85103107098 0.9646329122989237 0.9805885471489348 0.9865726350754942 0.9001840643553959 1.0151158110554006 0.9941524910836292 0.9686841102491558 0.9847464123479628 1.0347828254640545 1.0 16.70948573100847 QDDS(ph)PSGASYGQDY(ph)DLSPSR ddPTM_A459_Selumetinib_30min_R2 1 QDDSPSGASYGQDYDLSPSR 20 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 2 QDDS(0.884)PS(0.115)GAS(0.205)Y(0.202)GQDY(0.563)DLS(0.021)PS(0.009)R 100.27 0.019515 4613500.0 14946.0 11220.0 15129.0 15060.0 14668.0 14073.0 10573.0 13915.0 14070.0 12445.0 True False 14115.361153578475 12080.537922013767 14155.61661120973 13008.802020050933 12825.274706416249 16011.428008025436 11064.66545000204 13955.490346247747 16884.39314864685 12085.680514006794 1.1679409477372307 0.9995744888351908 1.171271786872404 1.076381425520415 1.061195907963337 1.3248263504457913 0.9155186120614854 1.1547128297884361 1.3970577104928887 1.0 13.561011089437532 -6.741245589283387 0.7978634668009769 1.1590410866537357 1.094206417813433 0.01726056292882605 0.14035436309128602 3.1209527143268745 4.357513092927238 0.09358755957039076 0.09186394417389761 1.8144892966436262e-07 6.741245589283387 -0.06483466884030276 QDDSPS(ph)GASYGQDYDLS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 QDDSPSGASYGQDYDLSPSR 20 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 2 QDDS(0.14)PS(0.86)GASYGQDYDLS(0.995)PS(0.005)R 237.41 1.1344e-28 7290100.0 23857.0 24253.0 25621.0 29312.0 32821.0 23407.0 25498.0 30166.0 22658.0 28131.0 True False 22531.123447137812 26113.12711431372 23972.5727540356 25319.65503397962 28697.732556537198 26631.10178240969 26683.70752332847 30253.778065749866 27190.233117415777 27318.7849368843 0.8247483736627519 0.9558670773478374 0.8775124080159643 0.926822151588244 1.0504761695235982 0.9748274619071311 0.9767530871148524 1.1074349805690993 0.9952943800478125 1.0 14.737605697565655 -6.112003359281601 4.316906022780251 1.0183514957784807 0.8939979187425093 0.616439522165695 0.04744149450339071 0.1587607472658769 4.907012234886857 0.014064436211911337 0.018663130030218054 7.726746084099677e-07 6.112003359281601 -0.12435357703597139 QDDSPSGASYGQDYDLS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 QDDSPSGASYGQDYDLSPSR 20 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 QDDSPSGASYGQDYDLS(1)PSR;QDDSPSGAS(0.008)YGQDYDLS(0.991)PSR 310.96 4.210499999999997e-117 20409200.0 3392.9 4240.0 4044.9 4171.9 4306.700000000001 3997.7 4262.6 4002.0 2378.7 2803.7 True False 3471.94796856585 3743.5788288774793 3495.624797045286 3443.3559812620424 3917.1597454096423 3957.4867676211807 3941.0686501610503 3895.8539596719374 4036.480166625821 3163.5822053506777 1.0974736052989622 1.1833354045758107 1.1049577883998123 1.0884357534437301 1.2382038749568172 1.2509511404280074 1.245761416755785 1.2314691722196258 1.2759207457289337 1.0 11.627343369280732 -6.2678834705416975 24.83911470988385 1.2227550421142719 1.1222072025806085 0.2238171803893534 0.07737685732111084 591.2863236956352 2279145.2719109105 0.02227980107421601 0.025864557461866597 5.396554028851807e-07 6.2678834705416975 -0.10054783953366342 QDDSPSGASYGQDYDLS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 QDDSPSGASYGQDYDLSPSR 20 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 QDDSPSGASY(0.002)GQDY(0.37)DLS(0.549)PS(0.079)R;QDDSPSGASYGQDYDLS(0.999)PS(0.001)R 264.54 4.3574e-48 25583000.0 56347.0 60353.0 63297.0 77808.0 72076.0 64748.0 59499.0 65589.0 56072.0 67897.0 True False 53215.459314912754 64981.8810345184 59224.53993256282 67210.4161737135 63021.16851238453 73666.44927617637 62265.82139503181 65779.85313115649 67287.9667825817 65936.63719240796 0.807069659309833 0.9855200962842022 0.8982038280135709 1.0193182278554571 0.9557837826712958 1.1172309115676047 0.9443281314656002 0.9976222011323695 1.0204943662235983 1.0 16.008792690131465 -3.6412179118511125 0.7613322106282113 1.0068196994622525 1.5683835542750098e-17 0.5144210297930903 0.054387613175679174 10.570889905409853 1.244679679147175 0.019484429658198327 13.534300931459835 0.0002284452267661563 3.6412179118511125 -1.0068196994622525 QDDSSSSAS(ph)PSVQGAPR ddPTM_A459_Selumetinib_30min_R1 1 QDDSSSSASPSVQGAPR 17 0 C4AMC7;Q6VEQ5;A8K0Z3;A8MWX3 C4AMC7 WASH3P;WASH2P;WASH1;WASH4P Putative WAS protein family homolog 3;WAS protein family homolog 2;WAS protein family homolog 1;Putative WAS protein family homolog 4 1 QDDSSS(0.006)S(0.186)AS(0.801)PS(0.006)VQGAPR 216.53 1.0335999999999998e-11 3195100.0 1344.2 1387.1 1773.1 1691.7 1587.3 1632.1 1675.2 1500.0 1018.0 1380.5 True False 1375.517244642111 1224.6976871547045 1532.3227589411345 1396.2763521419495 1443.7289952605759 1615.682555828233 1548.8383152887418 1460.2151273133197 1727.4716482217545 1557.7006222087264 0.8830433942381751 0.7862214790786668 0.9837081253574852 0.8963701575480615 0.9268334201558285 1.037222771046526 0.9943106481478974 0.9374170533762912 1.1089882250751772 1.0 10.605202270078937 -5.76835717328496 0.5272962238392849 1.0240357405716844 0.8036235953030562 0.5220767854152855 0.05909457576610011 1.3768840748376725 0.5941813402189788 0.04123206455413496 0.1679663808752666 1.7046798463346008e-06 5.76835717328496 -0.2204121452686283 QDDSSSSAS(ph)PSVQGAPR ddPTM_A459_Selumetinib_30min_R2 2 QDDSSSSASPSVQGAPR 17 0 C4AMC7;Q6VEQ5;A8K0Z3;A8MWX3 C4AMC7 WASH3P;WASH2P;WASH1;WASH4P Putative WAS protein family homolog 3;WAS protein family homolog 2;WAS protein family homolog 1;Putative WAS protein family homolog 4 1 QDDS(0.045)S(0.141)S(0.009)S(0.168)AS(0.584)PS(0.052)VQGAPR;QDDSS(0.024)S(0.089)S(0.33)AS(0.52)PS(0.038)VQGAPR 195.25 9.2946e-08 9497700.0 26292.5 25250.6 29317.0 32122.0 34075.0 29705.0 28479.0 34027.0 26768.3 30723.0 True False 24831.268107216783 27187.23982652414 27430.776137936144 27746.928186459245 29794.19386563494 33796.59411485794 29803.329930067914 34126.01293652689 32122.707968793402 29835.9471620595 0.8322600912362905 0.9112242919204672 0.9193868050824993 0.9299831520597165 0.9986005707746509 1.132747485148886 0.9989067807428932 1.1437884894742942 1.07664448506739 1.0 14.86476395648638 -6.293936100276109 1.68662556840659 1.0761286071292766 0.8877007912329163 0.7218504839571127 0.05038645218335623 0.18650127568442534 1.0505865114258344 0.01759518747532768 0.022965301707578902 5.082342158730569e-07 6.293936100276109 -0.18842781589636026 QDEHGYISR ddPTM_A459_Selumetinib_30min_R1 3 QDEHGYISR 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 ;; 143.5 0.002849 67160600.0 27894.8 28534.3 33861.0 35794.4 37303.6 29313.7 33354.6 31630.8 18797.899999999998 28537.3 False True 28544.6945661678 25193.49089076382 29262.862185159163 29543.5799841046 33929.4959664855 29018.83079271005 30838.635668057497 30791.84843268145 31898.66335570503 32200.340431841454 0.8864718255568891 0.7823982775614111 0.9087749319638387 0.9174927838616977 1.053699914704447 0.9011963974149368 0.9577114792725163 0.9562584749021097 0.9906312457542185 1.0 14.974788320582919 -5.653738582892673 2.2870321152561055 0.9692244775603183 0.8358936537354801 0.5726376758669743 0.04629693115338687 0.2038315774940162 2.1531689636918783 0.013007399294013297 0.027079266604571335 2.2195320320959174e-06 5.653738582892673 -0.13333082382483818 QDEHGYISR ddPTM_A459_Selumetinib_30min_R2 3 QDEHGYISR 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 ;; 150.15 0.001897 132805000.0 356461.0 347965.0 375319.0 422052.0 450140.0 308244.0 320753.0 342567.0 306307.0 357150.0 False True 336650.3246464433 374652.7966161777 351171.3841564299 364567.78951969097 393589.3888973413 350701.81303956476 335668.65006001154 343563.81325497985 367576.95893266384 346838.15151285904 0.9706265679770871 1.0801948833540806 1.0124935294017394 1.0511179001776412 1.1347926610165577 1.0111396670460069 0.9677962144472062 0.9905594634165907 1.0597939048208653 1.0 18.40390307533535 -6.974583314805115 24.999476530070062 1.0017102313514703 1.051870764751981 0.19049149674773402 0.04525614625301849 349.5829864892078 343843.612244539 0.015958116945450396 0.014073224680922048 1.0602705171710126e-07 6.974583314805115 0.05016053340051063 QDENDDDDDWNPCK ddPTM_A459_Selumetinib_30min_R1 2 QDENDDDDDWNPCK 14 0 Q14974;Q14974-2 Q14974 KPNB1 Importin subunit beta-1 0 ; 259.7 3.6135999999999984e-93 6501500.0 2778.3 3431.7 3779.8 4176.3 3104.6 3294.5 2977.2 2653.6000000000004 1741.88 2964.2 False True 2843.028984369274 3029.9149686459527 3266.523920955217 3446.987603860271 2823.7894781616487 3261.3603211666637 2752.6274070425275 2583.217907892417 2955.8431381183777 3344.683943753066 0.8500142411599926 0.9058897700349196 0.9766315669545308 1.0305869438869641 0.8442619768112014 0.9750877440177785 0.8229858047375942 0.772335428798032 0.8837436325303818 1.0 11.707654174356025 -7.268055038793139 24.92855752692223 0.8507941679971408 0.9320357722934687 0.11115176659160708 0.07677701776706855 863.3827714330679 3253308.1045174887 0.031307847898393026 0.02167535323335565 5.39442253854502e-08 7.268055038793139 0.08124160429632787 QDENDDDDDWNPCK ddPTM_A459_Selumetinib_30min_R2 4 QDENDDDDDWNPCK 14 0 Q14974;Q14974-2 Q14974 KPNB1 Importin subunit beta-1 0 ;;; 259.7 1.2949999999999999e-34 129902000.0 375611.0 376071.0 414042.0 416990.0 426845.0 333857.0 343074.0 380788.0 294000.0 418791.0 False True 354736.044309967 404914.4364411452 387402.9884948438 360195.2426521274 373220.915057284 379842.77129790006 359027.6207882338 381896.03003715345 352808.2150463522 406699.41568030725 0.8722315071846897 0.9956110602318515 0.9525535900926111 0.885654684429802 0.917682447202384 0.9339643890624169 0.8827837143254058 0.9390129793974159 0.8674913251502748 1.0 18.63360339246644 -5.730121706293485 24.978753935137863 0.9147171521525157 0.9456799741543337 0.04020180755597047 0.04502487211882305 488.1465483248083 389338.58562303125 0.011364895503485403 0.019681984398351057 1.861565380156666e-06 5.730121706293485 0.03096282200181799 QDGGQNES(ph)FKR ddPTM_A459_Selumetinib_30min_R1 1 QDGGQNESFKR 11 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 1 QDGGQNES(1)FKR 107.93 0.018433 3259100.0 965.76 1421.2 814.38 1024.2 1017.8 1039.1 1403.2 1078.4 746.39 1443.5 True False 988.2603289581649 1254.8052433020441 703.791669069133 845.3426966151115 925.7401697071848 1028.6475974273128 1297.3554942771984 1049.7973288631235 1266.5693158312727 1628.7872858806943 0.606746097249775 0.7703923367891247 0.4320955076025099 0.5190012863822363 0.5683616134114358 0.6315420106383735 0.7965162213159781 0.6445269667582727 0.7776149327850577 1.0 10.669582489726851 -8.617532758368293 0.5425661605729271 1.0063227888904787 0.57940479585819 0.6324287804490429 0.09435451372305698 0.7473085016622005 0.5101660317201373 0.11537857464153722 0.05044349415353787 2.412499553467318e-09 8.617532758368293 -0.4269179930322886 QDILDDSGYVS(ph)AYK ddPTM_A459_Selumetinib_30min_R1 1 QDILDDSGYVSAYK 14 0 Q9BW30 Q9BW30 TPPP3 Tubulin polymerization-promoting protein family member 3 1 QDILDDSGYVS(1)AYK 148.52 0.00045787 4029100.0 991.71 1214.3 1176.0 1076.1 1058.4 1156.9 878.32 1044.9 914.01 1036.0 True False 1014.814913468255 1072.1291914872454 1016.3056593056074 888.1793358987716 962.6679068756966 1145.2626363811546 812.0676152605109 1017.1858576864587 1551.0082133508508 1168.9806914945616 0.868119482940986 0.9171487598452205 0.8693947356874162 0.7597895691187331 0.8235105283432094 0.9797104817162694 0.6946800928099751 0.8701476979794844 1.3268039623202506 1.0 10.191035385177424 -8.176412913670735 7.640696056818933 1.1616336116375094 0.8454027227701103 0.5950711013621385 0.10419763442104912 0.16515299271883346 12.986555414271457 0.06748050288553321 0.025225192908478654 6.661730913881727e-09 8.176412913670735 -0.31623088886739914 QDIMPEVDKQSGS(ph)PESR ddPTM_A459_Selumetinib_30min_R1 1 QDIMPEVDKQSGSPESR 17 1 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 QDIMPEVDKQS(0.048)GS(0.765)PES(0.187)R 78.057 0.010563 15836000.0 1735.0 1743.5 1925.8 2000.1 1854.9 1816.7 1995.3 2015.4 1210.8 1641.2 True False 1775.4221242776844 1539.3702094688394 1664.2869376621943 1650.8200815269327 1687.1246225091934 1798.425647431622 1844.7929145747541 1961.9450450581764 2054.639166666895 1851.8640066417709 0.9587216544573871 0.8312544571025938 0.8987090475829622 0.8914369930006806 0.9110413164564275 0.9711434754288164 0.9961816353459779 1.059443370583151 1.1094978677148346 1.0 10.854762441496042 -7.15418051385138 1.255895255943645 1.063151383345899 0.8898104180424079 0.7519801700663207 0.0394119447595855 0.2069229163997846 0.6481201133988895 0.023051721169744417 0.014548172100428561 7.011638001596786e-08 7.15418051385138 -0.17334096530349108 QDIMPEVDKQSGS(ph)PESR ddPTM_A459_Selumetinib_30min_R2 1 QDIMPEVDKQSGSPESR 17 1 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 QDIMPEVDKQS(0.038)GS(0.948)PES(0.013)R 111.57 0.009555 4066700.0 13880.0 14973.0 14650.0 17807.0 16349.0 13463.0 12082.0 11655.0 9407.9 15363.0 True False 13108.605166042378 16121.380954216771 13707.434949713957 15381.655881211631 14295.092458085575 15317.406045054111 12643.836940028816 11688.914120410882 11289.742878689036 14919.430272132278 0.8786263903473375 1.0805627735215595 0.9187639675033581 1.0309814517477074 0.9581527040470914 1.0266749980168615 0.8474745154073342 0.7834692013839418 0.7567140750526469 1.0 13.864904824039183 -7.3384599704780005 5.703404721790191 0.8263498528861494 0.9848081524436592 0.38988229972070165 0.08152897038470405 0.19828122615942487 11.220308860758935 0.032259191502972524 0.021575100694234173 4.587119239610988e-08 7.3384599704780005 0.15845829955750979 QDIMPEVDKQSGSPES(ph)R ddPTM_A459_Selumetinib_30min_R1 1 QDIMPEVDKQSGSPESR 17 1 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 QDIMPEVDKQS(0.004)GS(0.109)PES(0.887)R 74.703 0.012598 18595000.0 2865.3 2743.3 2704.0 2563.0 2533.2 2635.3 2734.3 2362.1 1514.5 2443.8 True False 2932.05591509674 2422.1131606744293 2336.8116520088115 2115.4201634685915 2304.0725072727837 2608.791274660955 2528.0495496024405 2299.4494348178614 2569.99588529651 2757.4855346278077 1.0633078136863174 0.8783774675363273 0.8474429412824547 0.7671554889059902 0.8355701157227563 0.9460761414340755 0.9167952171845807 0.833893562066584 0.9320070234360798 1.0 11.429137602328078 -6.764298743444432 24.999663592221253 0.914812784319886 0.8704743004841733 0.06770770002045379 0.08046894081336699 248.75326932175736 2174857.0745345983 0.029069712404723905 0.02675372304707755 1.7206845395246193e-07 6.764298743444432 -0.044338483835712705 QDITLEPS(ph)PTAR ddPTM_A459_Selumetinib_30min_R1 1 QDITLEPSPTAR 12 0 A0A0C4DGJ6;Q96DN6 A0A0C4DGJ6 MBD6 Methyl-CpG-binding domain protein 6 1 QDITLEPS(0.5)PT(0.5)AR 98.654 0.015086000000000004 3041000.0 646.73 576.64 725.32 901.46 699.79 671.61 962.29 629.17 298.0 509.33 True False 661.7975506824821 509.12672072733704 626.8255278975715 744.0369334999592 636.4941180579591 664.8542131730899 889.7036905558762 612.4823677678146 505.68423494114245 574.707466794329 1.1515381109870286 0.8858884739521553 1.0906862432011764 1.2946359260827707 1.1075097416225876 1.1568567516298196 1.5480983664934271 1.0657289197653737 0.8798984947277744 1.0 9.166683983053094 -4.447004620790742 22.194181687735156 1.1290838922021782 2.2362656755095984 0.0 0.18644185106094416 4067.964165977209 3007290.807863817 0.04699893576366212 344404.0422063144 3.572690368735124e-05 4.447004620790742 1.1071817833074202 QDITLEPSPT(ph)AR ddPTM_A459_Selumetinib_30min_R2 2 QDITLEPSPTAR 12 0 A0A0C4DGJ6;Q96DN6 A0A0C4DGJ6 MBD6 Methyl-CpG-binding domain protein 6 1 QDITLEPS(0.006)PT(0.994)AR;QDITLEPS(0.004)PT(0.996)AR 147.51 0.0014682 7646800.0 39912.0 38281.0 37595.0 42180.0 41572.0 30807.0 34402.0 38855.0 28843.0 37737.0 True False 37693.85082039503 41217.02960718443 35176.178630341055 36435.01123544148 36349.353701604596 35050.38461189795 36001.76116626976 38968.06161720846 34612.40594075485 36647.43475749891 1.0285535964473476 1.1246907151871108 0.9598537759356595 0.9942035909617396 0.9918662504519961 0.9564212295848575 0.9823814792085269 1.0633230367982223 0.9444700882828464 1.0 15.161424595857834 -5.269369290962253 24.98751437699252 0.9880626399398657 1.0766221573275738 0.47697750413533324 0.03769547497010379 430.63069017155743 1356940.3250559296 0.00944194027680271 0.02029213416891782 5.378122734176084e-06 5.269369290962253 0.08855951738770818 QDKPLS(ph)PAGSSQEAADTPDTR ddPTM_A459_Selumetinib_30min_R2 1 QDKPLSPAGSSQEAADTPDTR 21 1 P13994 P13994 CCDC130 Coiled-coil domain-containing protein 130 1 QDKPLS(0.998)PAGS(0.001)S(0.001)QEAADTPDTR 73.796 0.001954 22796000.0 63490.0 56784.0 57728.0 65813.0 62851.0 47216.0 54993.0 62408.0 52406.0 54874.0 True False 59961.479970607325 61139.15021066221 54013.84332949401 56849.15586624253 54955.09548493093 53719.57541582668 57550.28346656219 62589.596947799415 62888.664345983394 53289.6450402257 1.125199462772653 1.1472988826349153 1.0135898501241967 1.0667955439247143 1.0312527967384293 1.008067803327953 1.07995246399409 1.1745170548716104 1.1801291657790527 1.0 15.701567602956805 -7.5883977935388245 8.059196941857149 1.132418927926248 1.063510208654384 0.1128491319868592 0.06247402382565507 0.4389202480635999 47.49168330115472 0.029963323224086968 0.01723313806745837 2.579896043335614e-08 7.5883977935388245 -0.06890871927186404 QDKPMDTSVLS(ph)EEGGEPFQK ddPTM_A459_Selumetinib_30min_R1 1 QDKPMDTSVLSEEGGEPFQK 20 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 QDKPMDTS(0.001)VLS(0.999)EEGGEPFQK 81.329 0.0020598 7957000.0 1516.7 1597.4 1868.4 1884.7 1684.9 1535.4 1464.2 1621.0 991.85 1742.9 True False 1552.0361590155403 1410.3756653888868 1614.6815423865621 1555.5725252006453 1532.5010924932556 1519.9552700316594 1353.754215165817 1578.0058142499267 1683.0970081421885 1966.6181922836588 0.7891903802706608 0.7171578453421825 0.8210447501818215 0.7909885768901066 0.7792570507616927 0.7728776617624342 0.6883665677849866 0.8023956151943906 0.855833132606059 1.0 10.941501178442264 -8.590907327541567 1.9143681273298356 0.9988826902982443 0.7673879167756452 0.7875471570213631 0.03693898134857855 0.18405554464263013 1.504390408134652 0.036071051706251335 0.010120091293105522 2.565031320465254e-09 8.590907327541567 -0.23149477352259906 QDKPMDTSVLS(ph)EEGGEPFQK ddPTM_A459_Selumetinib_30min_R2 4 QDKPMDTSVLSEEGGEPFQK 20 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 QDKPMDT(0.001)S(0.001)VLS(0.998)EEGGEPFQK;QDKPMDTSVLS(0.999)EEGGEPFQK;QDKPMDT(0.008)S(0.031)VLS(0.961)EEGGEPFQK;QDKPMDTSVLS(1)EEGGEPFQK 122.68 0.00013269 36286800.0 157217.0 160279.0 169051.0 200079.0 204885.0 155439.0 181475.0 188049.0 152268.0 159994.0 True False 148479.50852951626 172571.88392178685 158174.44270881207 172827.89504447326 179145.51460486045 176849.31131524665 189913.94708589034 188596.191456812 182725.8547233943 155374.5575056649 0.9556230499585027 1.1106830274673183 1.0180202296186431 1.1123307304554801 1.1529913100369014 1.1382128075170788 1.2222975893525305 1.2138164348428528 1.1760345944459547 1.0 17.245390757040127 -5.931141477749367 1.2289240157093708 1.1692853815977664 1.0219398737738439 0.3721424559373956 0.06852634377156652 0.4618146969763335 1.4118617553243227 0.024148064807484694 0.05022959269554533 1.171813568035951e-06 5.931141477749367 -0.14734550782392253 QDPSVLHTEEMR ddPTM_A459_Selumetinib_30min_R1 2 QDPSVLHTEEMR 12 0 Q3KNR6;P50502;F8WAQ7;Q8NFI4 Q3KNR6 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 0 ; 148.96 0.00082744 14219500.0 6728.0 7324.6 7976.299999999999 7977.099999999999 9471.7 7102.1 8174.900000000001 7648.8 4054.3 5998.5 False True 6884.749309590921 6467.032426885843 6893.162270679698 6584.049233712561 8614.986407364451 7030.659322190857 7558.260711350248 7445.928977196082 6879.850985643871 6768.4659053379555 1.0171801713828919 0.9554650222564633 1.0184231356241893 0.9727535494446453 1.2728122631998835 1.0387374953970179 1.116687417364313 1.1000910813961322 1.0164564735737343 1.0 12.724613164022154 QDPSVLHTEEMR ddPTM_A459_Selumetinib_30min_R2 2 QDPSVLHTEEMR 12 0 Q3KNR6;P50502;F8WAQ7;Q8NFI4 Q3KNR6 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 0 ; 143.55 0.0011473 10738300.0 84494.0 59555.0 84712.0 106341.0 115585.0 78041.0 72868.0 82017.0 70544.0 82593.0 False True 79798.16173628121 64122.677000492855 79261.72214745189 91857.17235154303 101064.17895698937 88790.43936433687 76256.50638520278 82255.65589135475 84654.77116404695 80208.32548761432 0.994886269613041 0.7994516356085081 0.9881981909682356 1.1452323906915065 1.2600210557019496 1.1069977938642765 0.9507305622154926 1.0255251607771887 1.0554362112586335 1.0 16.2914643732908 -5.525250768293015 6.660259872474608 1.0815359300993124 0.8956587289465601 0.3878549082501326 0.09125255673499202 0.13701727562864632 31.393950107519842 0.026738869580104112 0.049740532100726244 2.9836593107982014e-06 5.525250768293015 -0.1858772011527523 QDPVTYISET(ph)DEEDDFMCKK ddPTM_A459_Selumetinib_30min_R2 1 QDPVTYISETDEEDDFMCKK 20 1 P35251-2;P35251;D6RAD2 P35251-2 RFC1 Replication factor C subunit 1 1 QDPVT(0.002)Y(0.003)IS(0.427)ET(0.569)DEEDDFMCKK 60.8 0.042314 2822500.0 16189.0 14716.0 12773.0 13631.0 14236.0 7754.4 7545.5 11717.0 7120.4 17123.0 True False 15289.280189701723 15844.66988060202 11951.19908619089 11774.43428521344 12447.54640854524 8822.498212565371 7896.380701124605 11751.094530146234 8544.678960598787 16628.614499103118 0.9194560491210116 0.9528556862904374 0.7187128601024151 0.7080827020103513 0.7485618485663139 0.5305612330504879 0.4748670252443765 0.7066791121280755 0.5138539329936149 1.0 14.02138034742037 -5.405763641858985 1.1559485712692603 0.6316849328244183 0.9817812298714055 0.3260216571813417 0.1448881751281894 0.7176576173197607 1.5368996259244643 0.04683713460073574 0.23483231460016374 3.928586845704165e-06 5.405763641858985 0.3500962970469872 QDPVVHLS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 1 QDPVVHLSPNK 11 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 QDPVVHLS(1)PNK 135.72 0.0014749 4222500.0 25723.0 20556.0 23750.0 25712.0 24878.0 21212.0 26740.0 27499.0 19635.0 24522.0 True False 24293.418637327664 22132.579102042346 22221.950857044834 22209.98124432602 21752.603227858137 24133.760456635788 27983.462984304795 27579.017537295487 23562.5486477385 23813.9861441924 1.0201323915379947 0.929394137043281 0.9331470473902236 0.9326444178578833 0.9134381407693487 1.013428004472127 1.1750852131544227 1.158101687399414 0.989441603982993 1.0 14.539521508310948 -7.007059801076382 5.763517438934515 1.0944714532463264 0.9446796925773172 0.5125827231831467 0.061426432825571836 0.11987354797230815 14.744004581856906 0.02268124115093108 0.018729611408910246 9.838756196461875e-08 7.007059801076382 -0.14979176066900923 QDQSPS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 QDQSPSLR 8 0 Q68D20;A0A2R8Y6S3;C9J167;P54278;P54278-3 Q68D20;A0A2R8Y6S3 PMS2CL;PMS2 Protein PMS2CL;Mismatch repair endonuclease PMS2 1 QDQS(0.025)PS(0.975)LR 100.69 0.015663 0.0 37644.0 34873.0 41480.0 46498.0 47055.0 35515.0 35363.0 37394.0 29995.0 33575.0 True False 35551.89718087167 37547.64696563156 38811.221960009214 40164.89218647598 41143.53022296267 40406.8688769291 37007.44957045515 37502.81034909006 35994.83813032423 32605.602511673584 1.090361607890645 1.151570407330722 1.1903237164874922 1.231840208200293 1.2618546217090238 1.2392615306667765 1.1350027823348947 1.1501952873179744 1.1039464189455543 1.0 14.9928322587713 -8.496089999579434 1.0696537680293392 1.002096593540507 1.1930603744930859 0.5923216605418213 0.048168458701914496 0.40990133802542894 1.0309462731291439 0.051106522968762835 0.016655007309451863 3.1908765358429335e-09 8.496089999579434 0.19096378095257882 QDS(ph)LDIYNER ddPTM_A459_Selumetinib_30min_R1 1 QDSLDIYNER 10 0 Q9ULQ0-2;Q9ULQ0 Q9ULQ0-2 STRIP2 Striatin-interacting protein 2 1 QDS(1)LDIYNER 119.62 0.0053448 5615800.0 1184.8 1361.7 1569.0 1898.0 1630.9 1500.5 1504.1 1067.8 602.6 1303.7 True False 1212.4035347805184 1202.2715309628452 1355.9384179000845 1566.5499298725663 1483.385382958782 1485.4063323449939 1390.6445260421433 1039.4784752967746 1022.5681878373567 1471.0425941133767 0.8241797617772281 0.817292127212316 0.9217533355771608 1.06492492885072 1.0083905040512062 1.0097643251725654 0.9453461997681374 0.7066270408867981 0.695131597092657 1.0 10.522623305168143 -7.745916498874794 24.32350331690666 0.7756595167942812 0.9460415423245211 0.2559778751348206 0.10755335756896876 198.25170478649036 310650.82085582137 0.05337200734959664 0.03066193352269339 1.7950787306534303e-08 7.745916498874794 0.17038202553023984 QDS(ph)LDIYNER ddPTM_A459_Selumetinib_30min_R2 2 QDSLDIYNER 10 0 Q9ULQ0-2;Q9ULQ0 Q9ULQ0-2 STRIP2 Striatin-interacting protein 2 1 QDS(1)LDIYNER;QDS(1)LDIYNER 102.63 0.015084 7560800.0 26652.0 25224.0 24839.0 25134.0 26189.0 16982.0 19431.5 20591.0 16432.7 20428.5 True False 25170.78853640932 27158.599692056636 23240.885782658377 21710.705841431634 22898.903687369428 19321.11635275265 20335.103252786797 20650.916400976446 19719.699168000632 19838.676125382688 1.2687736004825663 1.368972381040509 1.171493784956886 1.0943626330818401 1.154255633926667 0.9739115770952155 1.0250231983357474 1.0409422619967335 0.9940027773713273 1.0 14.276028134554931 -5.682402037962087 0.8470775151973324 1.0113194348011962 1.3579025866837173 0.833314018975098 0.050717653638699206 0.32541641535574145 0.40167399543186133 0.021728768048596723 0.08307203484542455 2.0777723473660953e-06 5.682402037962087 0.3465831518825211 QDS(ph)MEALQMDR ddPTM_A459_Selumetinib_30min_R2 1 QDSMEALQMDR 11 0 Q8TDR0-2;Q8TDR0 Q8TDR0-2 TRAF3IP1 TRAF3-interacting protein 1 1 QDS(1)MEALQMDR 115.1 0.006275 2569300.0 9207.3 8164.8 10840.0 11605.0 12224.0 8722.3 7474.0 8370.0 9310.7 10312.0 True False 8695.595125742211 8791.013906030123 10142.566201699618 10024.378980258383 10688.311836053452 9923.717651843976 7821.55580945004 8394.35531427191 11173.100162694118 10014.265766206352 0.8683207864410727 0.8778490716409629 1.0128117665826506 1.00100988073296 1.0673085861293699 0.990958087544677 0.7810413655930999 0.8382397182426582 1.1157183585438997 1.0 13.289769027930785 -5.412398973942876 0.006896926924260123 1.8809865684691822 4.909586190867894e-05 0.03979523484788039 0.10020877559739544 66607.11006946537 89.20988193124819 11681.444820752242 12658.216908660159 3.869020457425489e-06 5.412398973942876 -1.8809374726072736 QDS(ph)PPPKPPR ddPTM_A459_Selumetinib_30min_R2 1 QDSPPPKPPR 10 1 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 QDS(1)PPPKPPR 68.515 0.043814 2443300.0 6771.1 6591.5 6869.6 8579.9 9666.5 7480.9 7202.1 8683.9 6325.5 8194.7 True False 6394.789368860914 7097.046854986966 6427.617415054956 7411.302818846948 8452.107850393553 8511.326070151172 7537.011920690414 8709.16871130297 7590.776749237078 7958.097718612414 0.8035575328391317 0.8918019237673319 0.8076826450650426 0.9312907532554393 1.0620764093692576 1.0695176625244078 0.9470871290085866 1.0943782068589016 0.9538431190011345 1.0 12.958207898859857 -6.003367766243347 3.9076121454526835 1.0238068675302234 0.8412853144931458 0.7346170231828908 0.05028372119309464 0.10586849576641791 3.6612908677790874 0.014146444513934769 0.02034546229543811 9.922754207489484e-07 6.003367766243347 -0.18252155303707762 QDVDLCLVS(ph)SCEYKHPK ddPTM_A459_Selumetinib_30min_R1 1 QDVDLCLVSSCEYKHPK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QDVDLCLVS(0.59)S(0.409)CEY(0.001)KHPK 69.259 0.019077 38266000.0 3298.2 2806.3 4751.9 4450.5 4040.3 3134.0 3740.0 3831.6 2148.9 2741.1 True False 3375.041642819972 2477.737091386525 4106.618080318295 3673.303721231747 3674.8555783729007 3102.474805444325 3457.8887889087255 3729.9735212091455 3646.5263505537596 3092.94688557504 1.0912058201065695 0.8010926740909309 1.3277363731885727 1.1876387979254959 1.1881405385626829 1.0030805313578843 1.1179916490114041 1.2059610653532673 1.178981238753409 1.0 11.594766343250777 -5.2567482234235134 24.99867561335644 1.154692969303095 0.9461492618162871 0.3482409951270733 0.11212163740041615 412.5249179030232 2198282.4113103705 0.028113966817991526 0.06954082242505959 5.536709997505254e-06 5.2567482234235134 -0.20854370748680784 QDVDLCLVSS(ph)CEYK ddPTM_A459_Selumetinib_30min_R1 2 QDVDLCLVSSCEYK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QDVDLCLVS(0.007)S(0.993)CEYK;QDVDLCLVSS(1)CEYK 297.72 7.510999999999995e-80 49481000.0 10273.8 13538.0 8561.599999999999 8714.400000000001 10092.1 10466.1 13746.900000000001 12621.5 7587.4 12594.2 True False 10513.159550665161 11952.964666354546 7398.981745502458 7192.593629547677 9179.271336904969 10360.820536458476 12709.960265307323 12286.736819590038 12875.263638229608 14210.788247896528 0.7398012951337385 0.8411190468708741 0.5206594888638673 0.5061361484020649 0.6459368176331584 0.7290813398751528 0.8943881256684437 0.8646062839905249 0.9060203708358963 1.0 13.794698960153466 -7.15740484470811 2.352895746039954 0.9122586126502604 0.6464007121089407 0.6312837139105724 0.096083254542199 0.2336570359678207 2.5298424646667437 0.04859240507484006 0.034539065255694446 6.95977428847812e-08 7.15740484470811 -0.26585790054131975 QDVDLCLVSS(ph)CEYK ddPTM_A459_Selumetinib_30min_R2 2 QDVDLCLVSSCEYK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QDVDLCLVS(0.1)S(0.9)CEYK;QDVDLCLVS(0.01)S(0.99)CEYK 199.65 7.945100000000001e-05 18044800.0 150281.0 114986.0 151428.0 162222.0 153395.0 129632.0 173040.0 176189.0 134727.0 135699.0 True False 141928.98364250807 123805.05646173582 141685.2873423406 140127.08375144092 134124.1487313006 147487.6313178679 181086.70287225523 176701.68082034102 161676.16458690463 131781.01728165607 1.077006283379667 0.9394756469145082 1.0751570314525354 1.0633328429385758 1.0177804929570133 1.1191872271151317 1.374148618728735 1.3408735526959534 1.2268547315988125 1.0 17.007783043219924 -7.038670780746663 5.096793642110076 1.2635704891957207 1.035401609201786 0.45642023378459795 0.10140979298860461 0.15518086552004098 9.998398234078689 0.037265033219401875 0.029620142269868942 9.148064526119477e-08 7.038670780746663 -0.22816887999393476 QDVDNAS(ph)LAR ddPTM_A459_Selumetinib_30min_R1 1 QDVDNASLAR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QDVDNAS(1)LAR 117.03 0.006151 27393000.0 2156.7 2065.7 2692.1 2904.9 2542.1 2511.7 2046.4 2413.2 1389.6 1570.4 True False 2206.9469137923224 1823.8468836821235 2326.527606646792 2397.613746726458 2312.1675038442086 2486.4345784411325 1892.0384004339091 2349.19409682167 2358.049707631581 1771.9761369913701 1.245472141368386 1.0292728246210043 1.3129565111395867 1.3530733832552366 1.3048525065185284 1.4031986811418566 1.0677561401286093 1.325748156411607 1.3307457467431263 1.0 10.791143460069678 -10.488660815902453 14.754101790851648 0.9999999893696053 1.2622378375647134 0.3188792732485559 0.11559120222775739 0.0 0.0 0.11487769346534145 0.027861932979761278 3.245930256136216e-11 10.488660815902453 0.2622378481951081 QDVDNAS(ph)LAR ddPTM_A459_Selumetinib_30min_R2 2 QDVDNASLAR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QDVDNAS(1)LAR;QDVDNAS(1)LAR 149.57 0.00074328 82829000.0 117319.0 98277.0 132496.0 151476.0 161300.0 92916.0 71204.0 97285.0 104333.0 138681.0 True False 110798.87964516737 105814.52988963903 123971.35161073746 130844.7074893254 141036.05195970397 105714.33559253115 74515.12708804924 97568.08324360121 125202.51530758837 134676.9191934895 0.8227013233498703 0.7856916428093811 0.9205092628576436 0.9715451487373394 1.0472176881108954 0.7849476823913087 0.5532880283739919 0.7244603145653024 0.9296508715625629 1.0 17.039143098672305 -6.969242256876018 24.433815862509558 0.7632066366290954 0.907645435467489 0.12523003377879427 0.13234771425769062 255.62039566154428 203062.68117930624 0.04835264329513981 0.04264253406690712 1.0733904897726913e-07 6.969242256876018 0.1444387988383936 QDVDNASLAR ddPTM_A459_Selumetinib_30min_R1 1 QDVDNASLAR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 178.54 0.0013439 12669000.0 3539.9 3105.3 3580.8 3923.1 3586.1 3447.5 3398.4 3626.8 2250.6 2565.2 False True 3622.3727825536425 2741.730032385198 3094.547027926463 3238.0042307076205 3261.737888177376 3412.821280079551 3142.055951932463 3530.605482493301 3819.103822679648 2894.4684071639463 1.2514811955066079 0.9472309407832147 1.0691244790467613 1.118687017862557 1.1268866780872164 1.1790839629248178 1.085538174870289 1.219776824564706 1.3194491303574727 1.0 11.4990826944413 -6.467567499682245 1.2649000748953476 1.1751525988492062 1.0786068349108648 0.06646563649640935 0.1046050871072172 0.9626120568019769 3.1914145504463196 0.0444049624772864 0.0525575502934843 3.4074736044781937e-07 6.467567499682245 -0.09654576393834136 QDVDNASLAR ddPTM_A459_Selumetinib_30min_R2 3 QDVDNASLAR 10 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ;; 144.55 0.013412 37183000.0 84128.0 78921.0 94707.0 99163.0 113723.0 72478.0 75235.0 70617.0 69089.0 84294.0 False True 79452.5025510671 84973.98692898829 88613.65472918481 85656.82833428349 99436.10004348068 82461.186610223 78733.57657532438 70822.48377872635 82908.73050795018 81860.2131978857 0.9705875351069719 1.0380376938864728 1.082499681682646 1.0463792480874683 1.2147060966370524 1.0073414591638616 0.9618051737172597 0.8651636858985796 1.0128086315574312 1.0 16.32087480371051 -6.996637431049386 24.999791103997175 0.9538316115086423 1.072279747684406 0.3705351640955572 0.06790416767002805 104.91511064862829 780005.7890662383 0.024532035042703394 0.021530970105154246 1.0077726525847692e-07 6.996637431049386 0.11844813617576366 QDVPPS(ph)PSQVAR ddPTM_A459_Selumetinib_30min_R2 1 QDVPPSPSQVAR 12 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 QDVPPS(0.95)PS(0.05)QVAR 107.13 0.0086113 5544800.0 28467.0 28193.0 31168.0 40919.0 38296.0 37517.0 32629.0 36891.0 31539.0 36218.0 True False 26884.91810242999 30355.31244521694 29162.684813152537 35345.76161078779 33484.914109416175 42684.626204582564 34146.3131531369 36998.34670236619 37847.68127328876 35172.29223433488 0.7643777642727867 0.8630461797307699 0.8291380220218967 1.0049319895131423 0.9520253580950434 1.2135867039940664 0.970829905700703 1.0519174143062742 1.0760652453678352 1.0 15.102151740311477 -5.831410959960632 1.4465356418713242 1.0558896287086779 0.8012340777668933 0.6691232494810064 0.0712048812527429 0.24165146054049547 1.0247516488257256 0.02318210112475924 0.04966517933485089 1.4743107765283945e-06 5.831410959960632 -0.2546555509417846 QEAGDS(ph)PPPAPGTPK ddPTM_A459_Selumetinib_30min_R1 3 QEAGDSPPPAPGTPK 15 0 J3KR72;P49848-4;P49848-2;P49848;P49848-3 J3KR72 TAF6 Transcription initiation factor TFIID subunit 6 1 QEAGDS(1)PPPAPGTPK;QEAGDS(1)PPPAPGTPK;QEAGDS(0.991)PPPAPGT(0.009)PK 174.87 2.2618000000000006e-05 31147100.0 12205.4 13983.7 13358.5 13253.7 12090.4 11444.2 13092.599999999999 12230.0 7540.9 12061.500000000002 True False 12489.762072425849 12346.481903154234 11544.48907298807 10939.19009776186 10996.825454733487 11329.081738502218 12105.01464108726 11905.620671361268 12796.356534455232 13609.711013959124 0.9177095722029238 0.9071817829556241 0.8482537991546764 0.8037782790936427 0.8080131491002513 0.8324263260904127 0.8894395060021086 0.8747886460741147 0.9402371969052351 1.0 13.73234881280176 -8.414901484844066 1.3047332181212719 0.9999866279597912 0.8531758618590736 0.6231445282087777 0.036068547346670365 0.3174696484663868 1.1575550528325873 0.039039236508322465 0.012064459018742363 3.846790325597964e-09 8.414901484844066 -0.14681076610071764 QEAGDS(ph)PPPAPGTPK ddPTM_A459_Selumetinib_30min_R2 2 QEAGDSPPPAPGTPK 15 0 J3KR72;P49848-4;P49848-2;P49848;P49848-3 J3KR72 TAF6 Transcription initiation factor TFIID subunit 6 1 QEAGDS(0.997)PPPAPGT(0.003)PK;QEAGDS(0.997)PPPAPGT(0.003)PK 195.55 3.3768e-05 22663000.0 132717.0 102419.0 123935.0 138201.0 131370.0 102936.0 103035.0 115485.0 96349.0 106071.0 True False 125341.12044824543 110274.20797100978 115961.15703022534 119377.78538997726 114866.12613729895 117114.49964002744 107826.3316599791 115821.04223042916 115621.49221598965 103008.45462444448 1.2168042021911984 1.070535504809341 1.1257440707464716 1.1589124972820264 1.1151135754447148 1.1369406527552692 1.0467716660064457 1.124383844536817 1.1224466247700802 1.0 16.652403228779093 -14.52287874527874 0.15027505745806946 0.5697283621364515 1.158508390639655 0.47851574471126734 0.04134854874923602 122.18105563154809 1.085581039198918 15.709487477063545 0.20350584160780497 3.0000000000110325e-15 14.52287874527874 0.5887800285032034 QEAGDSPPPAPGT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QEAGDSPPPAPGTPK 15 0 J3KR72;P49848-4;P49848-2;P49848;P49848-3 J3KR72 TAF6 Transcription initiation factor TFIID subunit 6 1 QEAGDSPPPAPGT(1)PK;QEAGDS(0.172)PPPAPGT(0.828)PK 180.03 2.2423e-09 4313700.0 57480.0 44394.0 47764.0 51758.0 45386.0 42494.0 53385.0 46951.0 34336.0 50606.0 True False 54285.49171067117 47798.877050791394 44690.91624151113 44708.4711124699 39684.20492401198 48347.16277787484 55867.508280370625 47087.61963684352 41204.15942799844 49144.873289821415 1.1046013160016521 0.9726116652882124 0.9093708712596729 0.9097280778161991 0.8074942973193326 0.9837681845827081 1.1367921929700358 0.9581389977171031 0.8384223352251963 1.0 15.584753304454654 -4.7799624033258965 3.6310571237986498 0.9436196015291063 1.12284984952075 0.23876311279835138 0.0861859885652664 0.441372689091969 9.9145260109318 0.023553469568624225 0.21650715367392973 1.6597305833338347e-05 4.7799624033258965 0.17923024799164367 QEAGISEGQGT(ph)AGEEEEK ddPTM_A459_Selumetinib_30min_R2 2 QEAGISEGQGTAGEEEEK 18 0 F8VVL1;O43583 F8VVL1 DENR Density-regulated protein 1 QEAGIS(0.001)EGQGT(0.999)AGEEEEK;QEAGISEGQGT(1)AGEEEEK 243.99 4.399800000000001e-25 11786900.0 96283.0 69890.0 88486.0 84451.0 87441.0 76073.0 75842.0 92611.0 66638.0 76187.0 True False 90931.97631138744 75250.3382682303 82792.90709627215 72948.62811389929 76455.87984754171 86551.36522806226 79368.80327807197 92880.48267742369 79967.4620212886 73987.28335240153 1.2290216938805323 1.0170712433082971 1.1190153678427335 0.9859617059656709 1.0333651457829889 1.1698140721807286 1.072735741627899 1.2553573866881127 1.080827115119276 1.0 16.174989706764315 -6.759461414279234 24.998913889916548 1.1290185024926 1.0708529914101474 0.033357426671363544 0.08865835174571511 135.7042683289952 1715135.042727238 0.028830543452894146 0.02745889254138596 1.7399572809910885e-07 6.759461414279234 -0.0581655110824526 QEAKPQQAAGMLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 QEAKPQQAAGMLSPK 15 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 QEAKPQQAAGMLS(1)PK;QEAKPQQAAGMLS(1)PK 171.33 0.00022084 106446000.0 8374.599999999999 10108.6 7129.200000000001 6238.2 5956.6 7402.200000000001 8023.7 8452.3 5140.0 9419.5 True False 8569.711885865067 8925.08041263936 6161.093797892465 5148.815475516882 5417.826581723149 7327.740588659854 7418.465849082072 8228.117547060248 8722.20458925326 10628.584578699823 0.8062890992126239 0.8397242686976057 0.5796720863697676 0.48443096419774906 0.5097411176066402 0.689437105609056 0.6979730738511525 0.7741498866697432 0.8206365132317772 1.0 13.375661863788768 -8.361695378982844 1.0167035582554194 0.9925788714484837 0.6450923217569383 0.5016714524796753 0.10799758312732394 0.48245054709299556 1.070576829354252 0.11727171702212251 0.03966540683556948 4.348151034248308e-09 8.361695378982844 -0.34748654969154535 QEAKPQQAAGMLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 5 QEAKPQQAAGMLSPK 15 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 QEAKPQQAAGMLS(1)PK;QEAKPQQAAGMLS(1)PK;QEAKPQQAAGMLS(1)PK;QEAKPQQAAGMLS(1)PK;QEAKPQQAAGMLS(1)PK 148.01 0.00017205 625312600.0 603676.0 439449.0 485998.0 482030.0 465320.0 425695.0 648618.0 576919.0 418683.0 414075.0 True False 570126.1046264977 473153.32524875534 454729.41779461264 416376.6824518696 406862.3415864202 484330.622175541 678780.0222121845 578597.7387759174 502431.2989804492 402119.5788539466 1.4178024015925188 1.1766483158996066 1.1308313290554162 1.0354548854312347 1.0117944088820312 1.2044442689308947 1.6880054041306043 1.438869851661884 1.2494574385370496 1.0 18.617265055856954 -7.019912365632692 24.407008968401524 1.3900227064295714 1.1438383355482369 0.1632732295509407 0.19197411157162134 783.720289440349 960620.2980635917 0.07233910029592332 0.056859756129473076 9.551853092054753e-08 7.019912365632692 -0.2461843708813345 QEASES(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 QEASESPVK 9 0 Q01167-2;Q01167;E9PPI7;Q01167-3 Q01167-2 FOXK2 Forkhead box protein K2 1 QEAS(0.009)ES(0.991)PVK 120.59 0.0065316 24971000.0 9967.2 11104.0 7137.6 7044.8 7887.9 8002.0 9155.4 9300.0 5240.7 9202.6 True False 10199.416367204914 9803.938517890447 6168.35312403036 5814.5579272741015 7174.44083772185 7921.50714523468 8464.80080694517 9053.333789342585 8893.085134416258 10383.843350914916 0.9822390441113741 0.9441531604987691 0.594033722926576 0.5599620228055331 0.6909234466725379 0.7628685138568388 0.8151895710367529 0.8718673311404394 0.8564348318710617 1.0 13.34205290388484 -8.207655781841027 0.9630866614810933 0.9839700637622788 0.7475284843416458 0.24995810523740392 0.12707200113720296 0.8143242556404894 1.5363473043278786 0.13490767035427764 0.048017443967370975 6.199322334888713e-09 8.207655781841027 -0.23644157942063304 QEASES(ph)PVK ddPTM_A459_Selumetinib_30min_R2 3 QEASESPVK 9 0 Q01167-2;Q01167;E9PPI7;Q01167-3 Q01167-2 FOXK2 Forkhead box protein K2 1 QEAS(0.002)ES(0.998)PVK;QEAS(0.003)ES(0.997)PVK;QEAS(0.014)ES(0.986)PVK 121.21 0.006335 67340900.0 112063.0 79498.0 100495.0 104976.0 105578.0 83511.0 109562.0 112394.0 91716.0 108572.0 True False 105834.98708373231 85595.24097364106 94029.2611106831 90678.08770629913 92314.34776070446 95013.8822126207 114656.85009298437 112721.04793217166 110061.76275915396 105437.24425606623 1.0037723181260325 0.8118121976496595 0.8918030983655305 0.8600195153628748 0.8755383205625962 0.9011415547040358 1.087441642675403 1.0690818858885944 1.043860388572529 1.0 16.686025043616375 -7.214949960897564 6.27455037270286 1.0558092828878505 0.884264030879707 0.7089832265841607 0.049906610683926836 0.10568992020570278 10.703814184393488 0.018400093465518012 0.014042725475132044 6.096071316956167e-08 7.214949960897564 -0.17154525200814352 QEASTGQSPEDHASLAPPLS(ph)PDHSSLEAK ddPTM_A459_Selumetinib_30min_R2 1 QEASTGQSPEDHASLAPPLSPDHSSLEAK 29 0 P48681 P48681 NES Nestin 1 QEASTGQSPEDHAS(0.001)LAPPLS(0.979)PDHS(0.018)S(0.002)LEAK 89.434 1.3278e-06 11021000.0 21946.0 21526.0 25265.0 35844.0 38261.0 20555.0 20885.0 18361.0 27075.0 32265.0 True False 20726.32917679869 23176.974983000746 23639.47740645211 30961.985365651137 33454.31112232015 23386.26467028799 21856.193882842395 18414.427470172817 32490.756538707414 31333.425615462354 0.6614766425848664 0.7396885124352129 0.754449184604525 0.988145558855591 1.0676876359733607 0.7463679508680144 0.6975360482786422 0.5876927628712802 1.0369359845121415 1.0 14.935414884600712 -8.300969465217797 24.810987062705586 1.0184682859671688 0.7907668936560932 0.3223253748704772 0.1374306745816653 773.9541360757851 485764.0227664482 0.1468252070135573 0.03791255044613067 5.000696931082061e-09 8.300969465217797 -0.22770139231107556 QEDTENHPKT(ph)PESAPENK ddPTM_A459_Selumetinib_30min_R1 1 QEDTENHPKTPESAPENK 18 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 QEDT(0.025)ENHPKT(0.964)PES(0.011)APENK 80.459 0.015569 3729700.0 1326.9 1671.4 738.62 815.4 823.24 942.27 1336.7 1093.0 631.49 1868.1 True False 1357.8141883020503 1475.7117109872204 638.3194609492417 673.0056969536827 748.778087354827 932.7916193127078 1235.8716428166554 1064.0100894356397 1071.5924077952411 2107.8888318349327 0.6441583482939482 0.7000899139935205 0.30282406325649536 0.31927950221541157 0.3552265546675012 0.4425241052682583 0.5863077901223187 0.5047752392660153 0.5083723541826501 1.0 11.041583067201936 -9.76936094349324 0.6970125111095012 1.031663489823699 0.4670666508598797 0.5992600265082679 0.12675723250584625 6.341983266699394 2.7645475122538885 0.6973993739189931 0.05168402744598658 1.7007444268752753e-10 9.76936094349324 -0.5645968389638192 QEEAEEQGAGS(ph)PGQPAHLAR ddPTM_A459_Selumetinib_30min_R1 1 QEEAEEQGAGSPGQPAHLAR 20 0 Q96S99 Q96S99 PLEKHF1 Pleckstrin homology domain-containing family F member 1 1 QEEAEEQGAGS(1)PGQPAHLAR 256.4 2.0832999999999996e-40 9838200.0 2559.1 3273.7 1977.1 1802.2 2455.0 2823.0 3768.7 3176.0 2006.9 2820.3 True False 2618.722050858223 2890.41368209816 1708.6206794329232 1487.4796014838441 2232.9456834654543 2794.6031830789175 3484.4239248022222 3091.7621628980683 3405.56272182342 3182.312977048371 0.8228989636610524 0.9082744855532874 0.5369115771314508 0.4674209017817906 0.7016738138486099 0.8781672963138093 1.0949343920389825 0.9715455975564384 1.0701532961670273 1.0 11.63586001480971 -6.930377310182924 3.033245489918519 1.0300534241538912 0.678354838458812 0.6408727753705603 0.1223482406930736 0.18548460501850422 3.4587155072102695 0.053249989534989745 0.045093904983556816 1.1738772603739775e-07 6.930377310182924 -0.3516985856950793 QEEAEEQGAGS(ph)PGQPAHLAR ddPTM_A459_Selumetinib_30min_R2 2 QEEAEEQGAGSPGQPAHLAR 20 0 Q96S99 Q96S99 PLEKHF1 Pleckstrin homology domain-containing family F member 1 1 QEEAEEQGAGS(1)PGQPAHLAR;QEEAEEQGAGS(1)PGQPAHLAR 190.33 9.6644e-16 122458000.0 135197.0 108452.0 131611.0 146706.0 163286.0 135333.0 136730.0 144015.0 127824.0 121515.0 True False 127683.29197647194 116769.91967185722 123143.29154722215 126724.38971803428 142772.55288463875 153973.89231934244 143088.2159253552 144434.05980703337 153392.37170096935 118006.54621611383 1.08200177083936 0.9895206953858993 1.0435293252435422 1.0738759313060042 1.2098697696242136 1.3047911091081257 1.2125447317414708 1.2239495556671995 1.2998632416548395 1.0 16.848507367342307 -6.208790549891498 3.254394752707104 1.2262984659619978 1.0365112358058737 0.47770457156319224 0.08209301976247525 0.19043921602135405 4.056556423498711 0.02415719716234991 0.031203885551964888 6.183145269309381e-07 6.208790549891498 -0.1897872301561241 QEEEAAQQGPVVVS(ph)PASDYKDK ddPTM_A459_Selumetinib_30min_R1 3 QEEEAAQQGPVVVSPASDYKDK 22 1 I3L0X5;I3L4C3;O75391 I3L0X5 SPAG7 Sperm-associated antigen 7 1 QEEEAAQQGPVVVS(0.999)PAS(0.001)DYKDK;QEEEAAQQGPVVVS(1)PASDYKDK;QEEEAAQQGPVVVS(1)PASDYKDK 135.03 9.8791e-06 42589000.0 9552.6 10534.300000000001 10477.4 9783.8 9108.7 9211.4 10405.5 10278.5 7165.2 10106.8 True False 9775.156993876077 9300.939258736793 9054.62662823859 8075.242994671868 8284.819693271596 9118.741679282026 9620.604757483883 10005.880790726644 12158.821074497566 11404.106228568759 0.8571611661585584 0.8155780972503341 0.7939795058691738 0.7080995943761328 0.7264768958848395 0.7996016080978271 0.8436088339288725 0.877392808360608 1.0661792192042328 1.0 13.477265762618728 -7.9740642514116775 1.7838109807471483 1.0342995148724126 0.7822379084494894 0.8026786827068326 0.047077436178464264 0.16482245788559483 0.9531206571869155 0.04331138244812399 0.014649374188072758 1.0615384969657058e-08 7.9740642514116775 -0.2520616064229232 QEEEAAQQGPVVVS(ph)PASDYKDK ddPTM_A459_Selumetinib_30min_R2 3 QEEEAAQQGPVVVSPASDYKDK 22 1 I3L0X5;I3L4C3;O75391 I3L0X5 SPAG7 Sperm-associated antigen 7 1 QEEEAAQQGPVVVS(0.998)PAS(0.002)DYKDK;QEEEAAQQGPVVVS(0.999)PAS(0.001)DYKDK;QEEEAAQQGPVVVS(0.969)PAS(0.031)DYKDK 112.75 2.2107e-05 104625500.0 282205.0 251550.0 262848.0 289716.0 290909.0 227718.0 292412.0 276629.0 193337.0 268791.0 True False 266521.17585612286 270843.076139266 245936.6458472637 250256.18101202435 254362.41066054287 259084.08748181182 306009.737403386 277433.9445916036 232009.80228713097 261030.30542711169 1.0210353752604577 1.0375924576883828 0.9421766007010146 0.9587246224247482 0.9744554765177229 0.9925440919891836 1.1723149804490194 1.0628418954559755 0.8888232418358634 1.0 17.993857786792475 -7.0338433981742465 24.990951725761025 1.0428315146748093 0.9853722842437949 0.07392175869880313 0.07029467563349306 1391.8539333935046 1027781.4489197537 0.02771828982986717 0.021484369517028697 9.250316700792692e-08 7.0338433981742465 -0.05745923043101442 QEEEDRDS(ph)PGPQVPDPK ddPTM_A459_Selumetinib_30min_R2 1 QEEEDRDSPGPQVPDPK 17 1 M0R353;Q6NSJ2-2;Q6NSJ2 M0R353 PHLDB3 Pleckstrin homology-like domain family B member 3 1 QEEEDRDS(1)PGPQVPDPK 72.771 0.014653 7241800.0 96234.0 90077.0 99877.0 107860.0 103720.0 82946.0 84799.0 96855.0 78745.0 93872.0 True False 90885.69953522485 96985.61625679447 93451.02255785558 93169.28193112166 90689.76633143518 94371.05859118016 88742.32152603084 97136.83201479148 94496.20031913275 91161.67145125322 0.9969727198762921 1.0638858931920252 1.0251130883205288 1.022022528195328 0.9948234262019825 1.035205444227107 0.9734608867223756 1.0655446578415726 1.0365781892191677 1.0 16.4761397562405 QEEEQDLDGEKGPSSEGPEEEDGEGFS(ph)FKYSPGK ddPTM_A459_Selumetinib_30min_R2 1 QEEEQDLDGEKGPSSEGPEEEDGEGFSFKYSPGK 34 2 P84157-2;P84157-3;P84157 P84157-2 MXRA7 Matrix-remodeling-associated protein 7 1 QEEEQDLDGEKGPS(0.008)S(0.027)EGPEEEDGEGFS(0.334)FKY(0.298)S(0.334)PGK 62.213 0.00013061 6918100.0 37628.0 23188.0 29331.0 39640.0 24030.0 19656.0 32104.0 21442.0 14238.0 26786.0 True False 35536.78639681861 24966.44503882846 27443.87539317818 34240.963617185895 21011.13656907433 22363.435580597452 33596.899612869136 21504.39267008582 17085.99784295904 26012.618581613973 1.3661364497127724 0.9597820750147407 1.055021635252663 1.3163212888297149 0.8077286222896932 0.8597148922332715 1.2915616129710148 0.8266908078714298 0.6568349814284221 1.0 14.66692401622189 -1.5228787452803443 0.272014784769137 0.8773769027827277 3.5982135804215494 0.25615302705824994 0.19785277553931774 81.73219275125649 1.143757203311629 0.23555507971329565 104.65987652851521 0.029999999999999537 1.5228787452803443 2.7208366776388218 QEEFS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QEEFSPR 7 0 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 QEEFS(1)PR 79.48899999999998 0.046662 12647000.0 41416.0 45952.0 59039.0 63442.0 65995.0 48027.0 44845.0 51663.0 46372.0 50068.0 True False 39114.26452138405 49476.37064103178 55240.49501680289 54801.090156445636 57704.11809721427 54642.2833043017 46930.3813586817 51813.330776729956 55647.695741936834 48622.406747713285 0.8044493709317175 1.017563176124733 1.1361119021406905 1.127074816365871 1.1867803746660093 1.1238086914912235 0.9652007067891356 1.0656266162547936 1.1444866567522174 1.0 15.569333686265626 -4.8021272059578735 2.8738563509702537 1.0966254687294406 0.760367159169264 0.645839942123894 0.06443101199057566 0.251373408151366 3.0162449707685823 0.017542765425705636 0.1960377531733144 1.5771492510141572e-05 4.8021272059578735 -0.33625830956017655 QEEGADAS(ph)EEDPTPAGEEDVKDAR ddPTM_A459_Selumetinib_30min_R1 2 QEEGADASEEDPTPAGEEDVKDAR 24 1 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 QEEGADAS(0.99)EEDPT(0.01)PAGEEDVKDAR;QEEGADAS(1)EEDPTPAGEEDVKDAR 129.54 6.6824e-08 17684200.0 3403.0 2815.0 3484.1 3314.2 3193.1000000000004 3152.5 3013.7 3097.7 2174.12 3057.8 True False 3482.283278914674 2485.418491342003 3010.9783567913855 2735.437185239018 2904.2846687875935 3120.7887122409834 2786.3741826562086 3015.5389332523137 3689.3228485578384 3450.2984154942737 1.0092701730600362 0.7203488487200762 0.8726718660826462 0.7928117675140723 0.841748834171939 0.9044982017284188 0.8075748376266305 0.8739936579718487 1.0692764521440163 1.0 11.75250543030225 -8.185386781208885 5.07595844534053 1.0338986655978362 0.8454091549838462 0.49618214883887723 0.0732765027779053 0.1528107301877851 6.970536463802632 0.04936499923490314 0.01742613661068257 6.525491357104124e-09 8.185386781208885 -0.18848951061399 QEEGADAS(ph)EEDPTPAGEEDVKDAR ddPTM_A459_Selumetinib_30min_R2 2 QEEGADASEEDPTPAGEEDVKDAR 24 1 Q86X53;E5RHA3;H0YB25 Q86X53 ERICH1 Glutamate-rich protein 1 1 QEEGADAS(1)EEDPTPAGEEDVKDAR;QEEGADAS(1)EEDPTPAGEEDVKDAR 138.54 3.2527e-08 29073000.0 101525.0 85509.0 101091.0 111982.0 107578.0 82544.0 88346.0 83290.0 64276.0 101052.0 True False 95882.64693677607 92067.26534522939 94586.91511955882 96729.85842027496 94063.08988047767 93913.68674017269 92454.26405427784 83532.36011059822 77132.9960214943 98134.36619537279 0.9770547327516863 0.9381755741096387 0.9638510828229995 0.9856879110799815 0.9585132459429173 0.9569908114880238 0.9421191335786834 0.8512039497386281 0.785993724847955 1.0 16.58247082952397 -7.669600395758667 4.549995219058065 0.8641393492027122 0.9619596674745364 0.33962058958178065 0.051207717295487724 0.1965417004748314 7.137985785127218 0.024302990425923137 0.013300755986501215 2.1399301824051437e-08 7.669600395758667 0.09782031827182425 QEEMNS(ph)QQEEEEMETDAR ddPTM_A459_Selumetinib_30min_R2 2 QEEMNSQQEEEEMETDAR 18 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 QEEMNS(1)QQEEEEMETDAR;QEEMNS(1)QQEEEEMETDAR 156.08 2.4446e-05 9209300.0 22816.8 25244.5 24832.3 29066.7 29913.6 23580.2 21755.6 23297.9 21670.3 29293.8 True False 21548.733598887284 27180.671976138736 23234.616853363976 25107.76531714574 26155.586137022972 26828.158510256628 22767.27850790358 23365.69303182502 26004.965518771984 28448.01187956707 0.7574776645240636 0.9554506687921271 0.816739565201474 0.8825841828046872 0.9194170140166932 0.9430591713695848 0.800311761830228 0.8213471342300566 0.9141224219415551 1.0 14.79604021128298 QEESES(ph)PVERPLK ddPTM_A459_Selumetinib_30min_R2 1 QEESESPVERPLK 13 1 D6RBF8;H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3 D6RBF8 SRPK1 SRSF protein kinase 1 1 QEES(0.003)ES(0.997)PVERPLK 85.988 0.014887 19010000.0 159170.0 100310.0 136400.0 169520.0 184800.0 168960.0 231430.0 233910.0 226960.0 141660.0 True False 150323.9686079946 108003.45445251357 127624.1725010912 146431.08356168907 161583.77186703865 192232.70633382918 242191.95356984533 234590.6393741147 272358.34179224464 137569.90772311765 1.0927096710026631 0.785080518261948 0.9277041368520513 1.064412166768375 1.1745575361746474 1.3973456078834443 1.760500952412478 1.705246759678486 1.9797813802449526 1.0 17.069805401406292 -6.733545362045394 1.539124936051723 1.6717040546865356 0.9417362318057161 0.570906025846643 0.24982755708322327 0.2458573415505985 1.210680687631687 0.10423138254003068 0.09678181709739613 1.8469478711855057e-07 6.733545362045394 -0.7299678228808195 QEGHLDSES(ph)PTNIPLTK ddPTM_A459_Selumetinib_30min_R2 2 QEGHLDSESPTNIPLTK 17 0 Q9H7P9;Q9H7P9-3;H7BXC7;E7ESZ3 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 QEGHLDSES(0.97)PT(0.029)NIPLTK;QEGHLDS(0.001)ES(0.998)PT(0.001)NIPLTK 125.04 0.00084449 23173700.0 243800.0 206561.0 256780.0 273850.0 295940.0 214820.0 218590.0 229330.0 198715.0 245310.0 True False 230250.57200872686 222403.56450170118 240259.05436092478 236551.15758240028 258761.371462832 244409.50505819856 228754.86812786775 229997.312332375 238463.55256100616 238227.26290807605 0.9665164649839967 0.9335772983611842 1.0085287948492812 0.9929642589802052 1.0861954601840822 1.025951027076645 0.9602379901251547 0.9654533638373846 1.0009918665481259 1.0 17.861979000198033 -5.270144004896419 24.5614537638214 1.0054203731376572 0.9500468810943884 0.29901196610441705 0.03367675187952958 600.2634954177081 1693742.3763450703 0.009789431140063372 0.020892193695749715 5.368537549920897e-06 5.270144004896419 -0.0553734920432688 QEGHNLGLLHGDMDQSER ddPTM_A459_Selumetinib_30min_R1 2 QEGHNLGLLHGDMDQSER 18 0 Q86XP3-2;Q86XP3;A0A0A0MSJ0 Q86XP3-2 DDX42 ATP-dependent RNA helicase DDX42 0 ; 91.14 0.0029615 42449000.0 3709.3 4530.5 4171.4 4556.4 4909.0 4077.3 4595.8 4528.4 2058.95 3208.3 False True 3795.7194729586245 4000.0669538276916 3604.946791860043 3760.710274220948 4464.981816754343 4036.286063892198 4249.135105900191 4408.292121683758 3493.8877702418285 3620.116556488417 1.048507531105724 1.1049552939554614 0.9958095922074154 1.0388367931083715 1.2333806790700301 1.1149602508399545 1.1737564356275683 1.217721046517874 0.9651312922451777 1.0 11.82182043300945 QEGPATQVDSAVGTLPAT(ph)SPQSTSVQAK ddPTM_A459_Selumetinib_30min_R1 1 QEGPATQVDSAVGTLPATSPQSTSVQAK 28 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06 E7ETY2 TCOF1 Treacle protein 1 QEGPATQVDSAVGTLPAT(0.487)S(0.487)PQS(0.004)T(0.017)S(0.006)VQAK 155.3 5.4457e-17 8195400.0 1854.2 1925.8 2375.4 2171.5 1983.8 1795.4 2625.8 2262.5 1231.9 2033.8 True False 1897.3992523548598 1700.3264407198697 2052.8337271382147 1792.2882891034128 1804.3656402683362 1777.3399060927702 2427.7337919562924 2202.491150364259 2090.444325583869 2294.8580408896114 0.8268046295444598 0.7409288114661466 0.8945362591327981 0.7810018123860178 0.7862646003013181 0.7744879528163654 1.0579015122936193 0.959750499211905 0.9109253332173434 1.0 11.164189196454121 -7.250793558416075 24.99771843224887 0.9787902121557324 0.8006728884709782 0.7522267058477865 0.051009186113321336 352.3989892022302 827478.2096222258 0.01949781107914954 0.014939604589394185 5.613147331992365e-08 7.250793558416075 -0.1781173236847542 QEGPATQVDSAVGTLPATS(ph)PQSTSVQAK ddPTM_A459_Selumetinib_30min_R2 2 QEGPATQVDSAVGTLPATSPQSTSVQAK 28 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06 E7ETY2 TCOF1 Treacle protein 1 QEGPATQVDSAVGTLPAT(0.236)S(0.691)PQS(0.01)T(0.047)S(0.016)VQAK;QEGPATQVDSAVGTLPAT(0.237)S(0.674)PQS(0.012)T(0.058)S(0.019)VQAK 167.83 5.9465e-22 14018000.0 62227.0 61208.0 75853.0 82762.0 83710.0 60764.0 79751.0 83960.0 65518.0 82902.0 True False 58768.672454417756 65902.45678526015 70972.70056250182 71489.6728275867 73193.60142310499 69133.68943932763 83459.5795236085 84204.30969967373 78623.43072587368 80508.40385473591 0.7299694148756954 0.8185786033489153 0.8815564234829486 0.8879777688373749 0.9091423741945094 0.8587139494662934 1.0366567405086988 1.0459070813477618 0.9765866289901443 1.0 16.296851766090228 -4.140345910135369 0.2950800902768077 1.0326467835070632 0.38908242474009425 0.7896727908113106 0.043877932021783174 5.564909672787967 0.29581187034620804 0.053661769527948516 1.380862643757333 7.23859185600198e-05 4.140345910135369 -0.6435643587669689 QEHLAES(ph)PVALGPER ddPTM_A459_Selumetinib_30min_R2 1 QEHLAESPVALGPER 15 0 G3V1S3;Q6ZUT9;Q6ZUT9-2 G3V1S3 DENND5B DENN domain-containing protein 5B 1 QEHLAES(1)PVALGPER 66.702 0.041287 3813700.0 13302.0 17079.0 15366.0 17211.0 17603.0 11510.0 14342.0 19316.0 13323.0 15993.0 True False 12562.728092125042 18388.904382359466 14377.368289235817 14866.832109368976 15391.553767183332 13095.398022622958 15008.93141813386 19372.206362064044 15987.972275722952 15531.240535195702 0.8088682976518428 1.1839945650631027 0.9257063694722216 0.9572211618047447 0.9910060778663609 0.8431649740371463 0.9663704186489015 1.2473057975094932 1.029407292964927 1.0 13.922885447040123 -7.572216290553634 24.906514593417615 1.1043820945013307 0.9582227615918958 0.24042189532912173 0.11206919728651259 143.7930780306441 72587.74015547102 0.05046838319259949 0.029137942837467293 2.677834357775508e-08 7.572216290553634 -0.14615933290943495 QEIESETTS(ph)EEQIQEEK ddPTM_A459_Selumetinib_30min_R1 1 QEIESETTSEEQIQEEK 17 0 D6RGZ6;P13611-2;P13611-5;P13611 D6RGZ6 VCAN Versican core protein 1 QEIESET(0.004)T(0.205)S(0.791)EEQIQEEK 307.57 3.673099999999998e-197 0.0 1411.3 2278.1 1423.7 1537.5 1601.9 1709.4 1874.0 1720.0 1062.7 1682.5 True False 1444.1805440882397 2011.3789929400427 1230.3693598243153 1269.0044874494574 1457.008427838416 1692.2049880110185 1732.6426712339437 1674.3800126526062 1803.3242834629257 1898.4652639378378 0.760709490724465 1.059476320766595 0.648086316455565 0.6684370325624293 0.767466466474218 0.8913542007616247 0.9126543972893445 0.8819650506428391 0.9498853193249538 1.0 10.890617886988549 -6.8641591059906695 4.178649116669681 0.9233128929442389 0.782782506422782 0.31671189036137215 0.108211574934162 0.32635099899820896 10.328460074832963 0.04166559359096399 0.036821618243739224 1.3672278429637244e-07 6.8641591059906695 -0.14053038652145688 QEIESETTS(ph)EEQIQEEK ddPTM_A459_Selumetinib_30min_R2 2 QEIESETTSEEQIQEEK 17 0 D6RGZ6;P13611-2;P13611-5;P13611 D6RGZ6 VCAN Versican core protein 1 QEIESETT(0.186)S(0.814)EEQIQEEK;QEIESETT(0.029)S(0.971)EEQIQEEK 226.74 3.411e-16 39135000.0 129579.0 116018.0 147553.0 144326.0 157103.0 111549.0 130687.0 143645.0 115189.0 129171.0 True False 122377.51792583597 124916.20754333296 138059.60062355903 124668.54982376301 137366.3166213602 126913.86220899799 136764.20445137785 144062.98316828994 138230.01864957256 125441.49760343673 0.975574433212787 0.9958124697955665 1.1005895438207571 0.9938381811885149 1.095062792183986 1.0117374603595368 1.090262848134483 1.14844757054577 1.1019480896709692 1.0 16.936655162951503 -2.376419799573211 0.43909895573621976 1.0836855220364503 5.2427201215426166e-09 0.27821797552404004 0.0496676650735073 47.63972810230809 1.23585505639149 0.03225128785360917 41.54074808129752 0.004203201403195788 2.376419799573211 -1.0836855167937303 QEKPAEKPAETPVAT(ph)SPTATDSTSGDSSR ddPTM_A459_Selumetinib_30min_R1 4 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 QEKPAEKPAET(0.001)PVAT(0.453)S(0.453)PT(0.055)AT(0.032)DS(0.004)T(0.002)S(0.001)GDSSR;QEKPAEKPAET(0.003)PVAT(0.505)S(0.34)PT(0.092)AT(0.054)DS(0.004)T(0.001)S(0.001)GDSSR;QEKPAEKPAET(0.034)PVAT(0.456)S(0.332)PT(0.106)AT(0.063)DS(0.003)T(0.003)S(0.003)GDSSR;QEKPAEKPAET(0.001)PVAT(0.531)S(0.46)PT(0.005)AT(0.003)DSTSGDSSR 108.3 3.8947e-10 377301000.0 8683.87 9136.6 11867.8 10662.09 9861.55 9396.66 9583.14 10260.460000000001 5793.95 8615.220000000001 True False 8886.187275130398 8066.882624509893 10256.217945159096 8800.156133717057 8969.574543698067 9302.138131884645 8860.276034369717 9988.319270128824 9831.909976635 9721.067406349206 0.9141164137311181 0.8298350672109421 1.0550505943884683 0.9052664451199396 0.9226944088300107 0.9569050129010583 0.9114509409309031 1.0274920286639577 1.0114023044643634 1.0 13.246899020025868 -7.763354076833935 24.999615401713275 1.0145853931516076 0.9290656955623146 0.3513148597649378 0.052937841613523405 57.406570864506676 749497.5168466375 0.02701583733096855 0.014012534457168926 1.724431403522568e-08 7.763354076833935 -0.08551969758929301 QEKPAEKPAETPVAT(ph)SPTATDSTSGDSSR ddPTM_A459_Selumetinib_30min_R2 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 QEKPAEKPAET(0.001)PVAT(0.337)S(0.337)PT(0.125)AT(0.066)DS(0.095)T(0.035)S(0.004)GDSSR 102.97 1.0211e-07 138000000.0 218290.0 213840.0 279970.0 265170.0 224530.0 197090.0 195320.0 211340.0 180670.0 215920.0 True False 206158.31568410606 230240.8403960268 261957.03500828776 229053.38855623608 196322.534076332 224237.35849511382 204402.76701923757 211954.96441077982 216809.04834157997 209685.82857246636 0.9831771516827079 1.0980276634024255 1.2492834484413273 1.0923646586687492 0.936269920637407 1.0693968210523037 0.9748048707478436 1.0108215984540379 1.0339709164782773 1.0 17.677869835923346 -6.020824479465305 24.024865417401777 1.0072477183504214 1.1192616898894705 0.3460231030130462 0.06826995793957819 504.13917407139985 581617.8199410833 0.020469717650303355 0.026769436667065157 9.531813153388088e-07 6.020824479465305 0.11201397153904913 QEKPAEKPAETPVATS(ph)PTATDSTSGDSSR ddPTM_A459_Selumetinib_30min_R1 2 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 QEKPAEKPAETPVAT(0.375)S(0.621)PT(0.004)ATDSTSGDSSR;QEKPAEKPAETPVAT(0.078)S(0.783)PT(0.105)AT(0.029)DS(0.001)T(0.001)S(0.001)GDS(0.001)SR 101.07 5.613e-08 641253000.0 10689.199999999999 11789.0 13614.4 13162.4 12781.5 10901.199999999999 12101.7 12667.0 7374.7 10239.400000000001 True False 10938.237562437469 10408.738399442585 11765.639258546145 10863.83392884861 11625.415581757105 10791.543825497665 11188.85902586543 12331.030011785222 12514.327273222962 11553.726730202126 0.9467280833156861 0.900898787248752 1.0183414869758056 0.9402882881460147 1.0062048249217785 0.9340314235828281 0.9684199122190669 1.067277277690079 1.0831420515174353 1.0 13.496070656989032 -7.7295015994651255 6.680651764024785 1.0565326239058779 0.959047890075563 0.5460078311275331 0.037860604279576916 0.12064708038333236 16.652538627331218 0.01796469194451636 0.00997451082533342 1.864225312475962e-08 7.7295015994651255 -0.09748473383031486 QEKPAEKPAETPVATS(ph)PTATDSTSGDSSR ddPTM_A459_Selumetinib_30min_R2 7 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 QEKPAEKPAETPVAT(0.118)S(0.879)PT(0.003)ATDSTSGDSSR;QEKPAEKPAETPVAT(0.114)S(0.848)PT(0.026)AT(0.01)DS(0.001)T(0.001)S(0.001)GDSSR;QEKPAEKPAETPVAT(0.048)S(0.943)PT(0.008)AT(0.001)DSTSGDSSR;QEKPAEKPAETPVAT(0.257)S(0.672)PT(0.044)AT(0.026)DS(0.001)TSGDSSR;QEKPAEKPAETPVAT(0.237)S(0.749)PT(0.011)AT(0.002)DSTSGDSSR;QEKPAEKPAETPVAT(0.096)S(0.881)PT(0.019)AT(0.003)DS(0.001)TSGDSSR;QEKPAEKPAETPVAT(0.077)S(0.908)PT(0.009)AT(0.005)DS(0.001)TSGDSSR 124.84 5.329e-14 1421444000.0 448102.0 376211.0 414119.0 477722.0 448681.0 342926.0 416710.0 413136.0 362859.0 427033.0 True False 423198.28473443235 405065.1739909731 387475.0343986763 412655.4394835835 392313.6815209667 390160.94372771477 436087.8406952 414338.15736165363 435440.9391275644 414703.4477250198 1.0204841243930174 0.9767586361123343 0.934342447655757 0.9950615114181681 0.9460101758813945 0.940819146472159 1.0515655056341844 0.9991191528178266 1.0500055919870122 1.0 18.661720515881584 -7.261779212014019 24.9999865117901 1.0250991588038196 0.9678454952109459 0.470351746561254 0.029234171765333723 27.938899215016985 2055207.20416865 0.01158488259678748 0.00836568340717424 5.472941272797877e-08 7.261779212014019 -0.05725366359287376 QEKPAEKPAETPVATSPT(ph)ATDSTSGDSSR ddPTM_A459_Selumetinib_30min_R2 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 QEKPAEKPAETPVATS(0.001)PT(0.307)AT(0.307)DS(0.056)T(0.056)S(0.14)GDS(0.096)S(0.038)R 101.29 8.508200000000001e-08 9867500.0 22834.0 21013.0 21383.0 25116.0 23067.0 20210.0 22180.0 20073.0 16888.0 20289.0 True False 21564.977691744352 22624.629532555744 20007.241060050073 21695.157472483348 20169.117238403567 22993.744051886162 23211.413948836223 20131.409106735962 20266.07189014556 19703.20385284723 1.094490918979559 1.148271606055903 1.0154308512196055 1.101097955160641 1.0236465799692271 1.1670053369804338 1.1780527736600581 1.0217327728569816 1.028567335622272 1.0 14.266142618713207 -7.897062917019713 12.842870024307894 1.0179111763075097 1.1015074524726356 0.3775473475597485 0.05127524343715568 0.6065579611946552 71.05434899255062 0.029126942705111156 0.013989531262236517 1.2674682321627971e-08 7.897062917019713 0.08359627616512588 QEKPS(ph)SPSPMPSSTPSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R2 1 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPS(0.307)S(0.307)PS(0.307)PMPS(0.059)S(0.017)T(0.005)PSPSLNLGNTEEAIR 109.71 5.1213e-11 10848000.0 24604.0 15927.0 20467.0 23871.0 22232.0 18907.0 17319.0 21391.0 16934.0 19478.0 True False 23236.608177615737 17148.549686623293 19150.175502784685 20619.728620228165 19439.017403398288 21511.267629342485 18124.367816947437 21453.24426852932 20321.273175492937 18915.619530078286 1.228434952430002 0.9065814449986624 1.0124001210921707 1.090090048990472 1.0276701417306333 1.137222473476842 0.9581694000625961 1.1341549894475242 1.0743117952430519 1.0 14.20729040829384 -5.756294903005713 24.951661801092154 1.0634197304740232 1.0348831090901423 0.0 0.0906019387582717 690.5761543887769 3349373.1031369446 0.02360295358222751 0.03934027830834181 1.752689952375846e-06 5.756294903005713 -0.02853662138388091 QEKPSS(ph)PSPMPSSTPSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R1 1 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPS(0.02)S(0.401)PS(0.291)PMPS(0.213)S(0.055)T(0.018)PS(0.001)PSLNLGNTEEAIR 96.351 3.1057e-07 8636400.0 346.32 381.62 360.32 285.76 379.56 344.14 380.4 435.8 274.03 369.98 True False 354.3885821785861 336.93975298967507 311.3905230960855 235.85738037954906 345.2288650167607 340.6782640541193 351.70612173820274 424.24116832209637 465.00889564067506 417.4705369103838 0.8488948341153493 0.8070982816734781 0.7458982025429258 0.5649677271241282 0.8269538434298398 0.8160534311604627 0.8424693257184318 1.0162182257503023 1.1138723682924145 1.0 8.705530572383719 -7.650443314224283 1.697328496332678 1.0682188723156611 0.7578995066815859 0.7079309392420368 0.07919532341754051 0.21393342949426242 1.1949489615332225 0.05955042112734539 0.02600033166299377 2.236437087989579e-08 7.650443314224283 -0.31031936563407525 QEKPSS(ph)PSPMPSSTPSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R2 1 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPS(0.044)S(0.322)PS(0.246)PMPS(0.246)S(0.1)T(0.041)PS(0.001)PSLNLGNTEEAIR 75.558 0.00011163 5454700.0 9544.7 8417.5 8232.7 9410.0 8187.2 7191.0 8041.9 9699.7 8534.2 11787.0 True False 9014.24378446143 9063.095183471563 7703.017045086021 8128.341766844582 7158.650741503344 8181.494976601357 8415.864284722536 9727.924521128218 10241.278465471354 11446.6786836961 0.7874986302621326 0.7917663659398811 0.6729477831903935 0.710104825290681 0.6253910797460976 0.7147483739763345 0.7352232483567083 0.8498469110506296 0.894694325617645 1.0 13.482641432748975 -8.143320535616043 1.3141329690693564 0.9882836574392359 0.7128805980296272 0.7934643583056407 0.04833317663098706 0.1993889365743916 0.6385566320820206 0.04886759565631333 0.015867938629532227 7.189181770144945e-09 8.143320535616043 -0.27540305940960863 QEKPSSPS(ph)PMPSSTPSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R1 5 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPS(0.005)S(0.068)PS(0.921)PMPS(0.004)S(0.001)TPSPSLNLGNTEEAIR;QEKPS(0.004)S(0.093)PS(0.795)PMPS(0.066)S(0.028)T(0.012)PS(0.002)PSLNLGNTEEAIR;QEKPS(0.011)S(0.042)PS(0.927)PMPS(0.019)S(0.001)TPSPSLNLGNTEEAIR;QEKPS(0.018)S(0.11)PS(0.327)PMPS(0.327)S(0.146)T(0.066)PS(0.004)PSLNLGNTEEAIR;QEKPS(0.097)S(0.258)PS(0.306)PMPS(0.306)S(0.023)T(0.008)PSPSLNLGNTEEAIR 135.34 5.9826e-14 83662900.0 6486.07 7221.53 5881.4400000000005 6158.63 7165.85 5418.59 7350.449999999999 6983.530000000001 3718.52 6862.889999999999 True False 6637.18281130476 6376.029910401781 5082.772752437396 5083.140882302992 6517.70013273357 5364.08390428608 6795.999638618753 6798.30409869759 6310.05685004475 7743.808781709563 0.8570953904468057 0.8233713008851151 0.6563659945274756 0.6564135331323112 0.8416659445579298 0.692693228293 0.8776042681568428 0.8779018555771675 0.8148518420223322 1.0 12.9188276131675 -7.283495136241775 21.648779259102717 0.8824148035890274 0.7527560669635274 0.4127747595550517 0.08024536734124287 166.53834472897879 163462.76868615835 0.034404618201999276 0.0232365239391581 5.206008390907651e-08 7.283495136241775 -0.12965873662549998 QEKPSSPS(ph)PMPSSTPSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R2 9 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPS(0.004)S(0.246)PS(0.747)PMPS(0.003)S(0.001)TPSPSLNLGNTEEAIR;QEKPS(0.018)S(0.243)PS(0.731)PMPS(0.004)S(0.001)T(0.002)PSPSLNLGNTEEAIR;QEKPS(0.001)S(0.016)PS(0.982)PMPS(0.001)STPSPSLNLGNTEEAIR;QEKPS(0.059)S(0.231)PS(0.673)PMPS(0.018)S(0.014)T(0.005)PSPSLNLGNTEEAIR;QEKPS(0.003)S(0.041)PS(0.584)PMPS(0.365)S(0.006)T(0.002)PSPSLNLGNTEEAIR;QEKPS(0.019)S(0.247)PS(0.728)PMPS(0.004)S(0.002)TPSPSLNLGNTEEAIR;QEKPS(0.032)S(0.228)PS(0.729)PMPS(0.005)S(0.002)T(0.002)PSPSLNLGNTEEAIR;QEKPS(0.221)S(0.221)PS(0.476)PMPS(0.053)S(0.019)T(0.009)PS(0.002)PSLNLGNTEEAIR;QEKPS(0.009)S(0.008)PS(0.393)PMPS(0.393)S(0.144)T(0.053)PSPSLNLGNTEEAIR 136.22 7.7991e-14 147507700.0 207413.0 157797.0 196906.7 228042.8 232689.2 183683.8 215792.0 229804.0 190644.4 194158.0 True False 195885.81580002478 169899.52250267414 184237.93729780463 196982.97724422827 203456.7024281587 208984.57613448062 225826.7555837362 230472.69159389965 228778.60704960136 188552.15405693295 1.0388946060031616 0.9010744181229206 0.9771192390736324 1.0447134811557213 1.0790473513589527 1.1083648297721285 1.1976885478356734 1.2223286058259981 1.2133439057955397 1.0 17.52460410664274 -6.398136211597019 1.171909638842953 1.1733474777249748 0.9644817361921222 0.5481801700158166 0.06874529183765236 0.3132892658332502 0.8961389263474415 0.029315654968304874 0.03762933034553175 3.9981933124168476e-07 6.398136211597019 -0.20886574153285264 QEKPSSPSPMPS(ph)STPSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R1 2 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPSSPS(0.002)PMPS(0.926)S(0.055)T(0.017)PSPSLNLGNTEEAIR;QEKPS(0.002)S(0.005)PS(0.196)PMPS(0.525)S(0.196)T(0.074)PS(0.002)PSLNLGNTEEAIR 126.5 2.2696e-13 59216000.0 3176.92 3801.04 3183.38 3250.54 3571.12 2765.3199999999997 3788.34 3858.46 1884.39 3935.07 True False 3250.9360547897754 3356.0124697444467 2751.0944810546657 2682.8942091928184 3248.1128265324423 2737.5033915096674 3502.582463789967 3756.12110675557 3197.6721995997955 4440.174565327706 0.7321640189950147 0.7558289477965057 0.6195915139322055 0.604231696236206 0.7315281817737984 0.6165305780737084 0.7888389098799902 0.8459399628307971 0.7201681268501641 1.0 12.116400681864022 -8.864940331788477 0.5090862443532367 1.008678553494177 0.6745631325591167 0.637221099346172 0.068710893870975 1.0117048072840162 0.5326115549236418 0.1006985843238999 0.037625150204095605 1.3647706310937623e-09 8.864940331788477 -0.3341154209350602 QEKPSSPSPMPSST(ph)PSPSLNLGNTEEAIR ddPTM_A459_Selumetinib_30min_R2 1 QEKPSSPSPMPSSTPSPSLNLGNTEEAIR 29 1 O95810 O95810 SDPR Serum deprivation-response protein 1 QEKPS(0.006)S(0.005)PS(0.013)PMPS(0.161)S(0.223)T(0.313)PS(0.259)PS(0.019)LNLGNTEEAIR 82.904 1.868e-05 30781000.0 64700.0 47048.0 60742.0 62184.0 62883.0 45128.0 65111.0 67716.0 58154.0 53512.0 True False 61104.23301462117 50656.43031683634 56833.92585088912 53714.431926616686 54983.075358847316 51343.97236880353 68138.79051499885 67913.04234901264 69786.42495852226 51966.96951912663 1.1758282920871792 0.9747813040780079 1.0936548037493545 1.033626405843175 1.05803890177992 0.9880116705652077 1.3111942286709661 1.3068501584264405 1.3428996457612776 1.0 15.665307309496106 -7.264372556196129 24.996970617676592 1.2658068615282225 1.0514511596924436 0.4276734451577796 0.1038537135206278 209.4446524603138 1784904.4708311497 0.039318883136527205 0.027818497978856313 5.440357557013609e-08 7.264372556196129 -0.2143557018357789 QELANSSDATLPDRPLS(ph)PPLTAPPTMK ddPTM_A459_Selumetinib_30min_R2 1 QELANSSDATLPDRPLSPPLTAPPTMK 27 1 A0A1B0GV05;Q684P5-3;Q684P5-2;Q684P5 A0A1B0GV05 RAP1GAP2 Rap1 GTPase-activating protein 2 1 QELANS(0.198)S(0.198)DAT(0.041)LPDRPLS(0.556)PPLT(0.005)APPT(0.002)MK 44.264 0.034047 2117100.0 9024.1 8221.9 10106.0 10796.0 9399.4 6957.7 8179.1 6614.8 6607.0 7094.5 True False 8522.576648334505 8852.49329242469 9455.790962580837 9325.566175861217 8218.563340297844 7916.060019287898 8559.444356579184 6634.047972860906 7928.584615004247 6889.663351275307 1.2370091561523016 1.2848948984983504 1.37246052244781 1.3535590493162506 1.1928831528142156 1.1489763165021118 1.2423603186641614 0.9628987128424663 1.1507941986071977 1.0 12.750217775093637 -7.18951846009731 0.8062960510480902 1.0328728355594279 1.313128259127776 0.6430351944432937 0.07667441627544254 0.403295398245696 0.5216605698284968 0.06070498014958144 0.03885196932342568 6.46370518825963e-08 7.18951846009731 0.2802554235683481 QELAVFCS(ph)PEPPAK ddPTM_A459_Selumetinib_30min_R1 2 QELAVFCSPEPPAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 QELAVFCS(1)PEPPAK;QELAVFCS(1)PEPPAK 115.87 0.0036621 7149100.0 8469.8 8690.3 9354.9 10138.0 9319.599999999999 8204.7 8364.9 8307.5 5010.8 6823.799999999999 True False 8667.129860638108 7672.835635989131 8084.55596278744 8367.58861382933 8476.643825509014 8122.168167271556 7733.928858380371 8087.158113436936 8502.961625647904 7699.70119944072 1.1256449615561261 0.996510830387348 1.0499830777036743 1.0867419912914442 1.100905555416193 1.054867969144247 1.0044453230135912 1.0503210324608907 1.104323584175647 1.0 12.910586745216463 -10.711864723847345 9.013277668987818 1.000000004497961 1.060735551613672 0.18308646552985897 0.03994373952544038 2.379648740152459e-09 2.571002413909277e-10 0.03887810836040954 0.009429325889898506 1.9414905283090398e-11 10.711864723847345 0.060735547115711164 QELAVFCS(ph)PEPPAK ddPTM_A459_Selumetinib_30min_R2 2 QELAVFCSPEPPAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 QELAVFCS(1)PEPPAK;QELAVFCS(1)PEPPAK 133.52 0.0007195 9063000.0 97716.0 104435.0 99431.0 126560.0 123804.0 99846.0 98209.0 103047.0 91010.0 111276.0 True False 92285.33590814102 112444.82868854773 93033.71771228717 109322.30967182272 108250.6346981973 113598.88018825477 102775.91309744163 103346.84970965076 109214.54303186567 108063.17275023051 0.8539943216496404 1.0405471709445795 0.8609197318990314 1.0116518596441961 1.001734744068639 1.0512265862378398 0.9510725114002577 0.9563558711025382 1.010654603713111 1.0 16.721515419869668 -4.7451715777247605 24.939149077823316 0.9839203256888085 0.8539939402423583 0.37208401651499423 0.05173425554233097 1055.2507620129356 1617649.0564534878 0.012663063780710722 0.3339755930599407 1.7981603714058928e-05 4.7451715777247605 -0.1299263854464502 QELGS(ph)PEER ddPTM_A459_Selumetinib_30min_R1 1 QELGSPEER 9 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF0 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 QELGS(1)PEER 85.92399999999998 0.034526999999999995 36995000.0 2998.2 3275.8 3512.6 3790.5 3426.9 2692.8 2982.6 2728.2 1757.3 2380.6 True False 3068.052226518357 2892.267813121897 3035.608213330679 3128.560331497346 3116.9375000683367 2665.712876866776 2757.6200806949646 2655.8392735574657 2982.009751886139 2686.173199007675 1.142164707641248 1.0767242462959414 1.13008655378294 1.1646904721754716 1.1603635615230599 0.9923830964628574 1.0265980174747047 0.9887073828815598 1.1101330893286225 1.0 11.391336614480913 -6.760402820479589 24.999999999864528 1.0230481286584918 1.1329772234989461 0.6695420539520738 0.03906425234955445 17.361415148385813 418728.5506877169 0.013381255464107152 0.012669046610156321 1.736189716364281e-07 6.760402820479589 0.10992909484045432 QELSHALYQHDAACR ddPTM_A459_Selumetinib_30min_R2 2 QELSHALYQHDAACR 15 0 F5H2I0;F5GY56;Q9UMS4 F5H2I0 PRPF19 Pre-mRNA-processing factor 19 0 ; 94.007 0.006704600000000001 6251100.0 21094.5 19832.5 26965.8 27574.5 33975.5 25432.0 23392.3 24278.6 21745.5 26374.0 False True 19922.152137974128 21353.58897846151 25230.849786143128 23818.8055313343 29707.193945176226 28935.027151289916 24480.088300963092 24349.246706461392 26095.20762003553 25612.51409211852 0.7778288404770296 0.833717022142408 0.9850985223628306 0.9299674934552333 1.1598702820945532 1.1297222540208889 0.9557862306260713 0.9506777280389722 1.0188460034099325 1.0 14.644561252563381 -5.221040603017869 1.4799350278398347 1.0285520430484874 0.7554752612055325 0.6075706733753917 0.06935824376582617 0.4271497092520855 1.453723847658177 0.02289839487358007 0.13428625133161 6.011175352333897e-06 5.221040603017869 -0.2730767818429548 QEMQEVQSS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 QEMQEVQS(0.212)S(0.788)R;QEMQEVQS(0.23)S(0.77)R 124.47 0.0038317 21085000.0 4483.8 9629.8 8115.9 9422.5 9808.9 7860.1 8984.4 6733.7 3063.9 6097.0 True False 4588.263816043964 8502.338539227438 7013.805357447603 7777.037257230896 8921.68672690195 7781.0345303997865 8306.699474618059 6555.1004018598 5199.2145215978735 6879.609339809205 0.6669366804730822 1.2358751957074405 1.0195063427311004 1.1304475113475818 1.2968304283320509 1.1310285433468494 1.2074376704140632 0.9528303248163208 0.7557426977012135 1.0 12.748110928147337 -7.94932787040671 6.072277469283493 0.8697186543549555 1.1098257877509652 0.21863939964533996 0.17195582656443956 0.2456681480564061 20.140422723145832 0.09437852811037983 0.04395141698557579 1.1237562743948211e-08 7.94932787040671 0.24010713339600964 QEMQEVQSS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 QEMQEVQS(0.087)S(0.913)R;QEMQEVQS(0.078)S(0.922)R 169.09 0.00024582 36349000.0 127253.0 134567.0 167027.0 150959.0 177358.0 104883.0 109568.0 121772.0 96756.0 164508.0 True False 120180.78769412028 144887.856198897 156280.6646652471 130398.12378119986 155076.7024393628 119329.68121692128 114663.12910487311 122126.33635956007 116109.9035885197 159758.22659688478 0.7522666610300478 0.9069195326290775 0.9782323451773627 0.8162216529245234 0.9706961935091155 0.7469391953005577 0.7177291057079686 0.7644447422899816 0.726785130643055 1.0 17.28553069772142 -6.780727709912759 24.998185609141643 0.7718667484765741 0.8874657206561655 0.1718686798261776 0.09827683222956475 340.62595116521726 441457.36518502166 0.03291074349348626 0.02906686786179616 1.6568084088816123e-07 6.780727709912759 0.11559897217959136 QEMQEVQSSR ddPTM_A459_Selumetinib_30min_R1 2 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 173.24 0.0016635 15273000.0 2857.8 2937.8 2940.4 3274.0 3238.8999999999996 2513.6 3034.3 2789.7 1675.1 2407.4 False True 2924.381179689199 2593.8410102538323 2541.1098304610614 2702.2573605915577 2945.942066874241 2488.315466166195 2805.420308071056 2715.708093777311 2842.5223555366006 2716.4132400617814 1.07655975775714 0.9548771784792356 0.935465117377821 0.9947887606857999 1.084497021081829 0.9160297960076212 1.0327663945590437 0.9997404127346787 1.0464248640873033 1.0 11.407487253949448 QEMQEVQSSR ddPTM_A459_Selumetinib_30min_R2 3 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ;; 185.33 0.004339899999999999 114338000.0 127728.0 108271.0 124322.0 153641.0 140252.0 96377.0 100863.0 119911.0 94605.0 111146.0 False True 120629.38909569592 116575.03755386361 116323.25787155912 132714.8307544916 122632.28989121143 109652.05692670123 105553.32935624295 120259.92115766543 113528.6434845584 107936.92618801129 1.1175914800980724 1.0800292510721115 1.0776965954073956 1.229559108653146 1.1361476949751455 1.0158901202698918 0.977916761983601 1.1141684815833015 1.0518054153849732 1.0 16.71982898258674 -6.7569000350955095 24.98835036227629 1.0357142193613276 1.1283531984264519 0.4633293928284611 0.05171416612689299 118.9787845942643 654958.2352831321 0.018634688415727494 0.018041859560288667 1.7502495106674233e-07 6.7569000350955095 0.0926389790651243 QENCGAQQVPAGPGT(ph)S(ph)TPPSSPVR ddPTM_A459_Selumetinib_30min_R2 1 QENCGAQQVPAGPGTSTPPSSPVR 24 0 Q96G46-2;Q96G46 Q96G46-2 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 2 QENCGAQQVPAGPGT(0.361)S(0.535)T(0.382)PPS(0.394)S(0.329)PVR 95.344 3.7482e-05 5554900.0 50303.0 42160.0 46023.0 55092.0 43878.0 42270.0 39299.0 34668.0 34895.0 39499.0 True False 47507.36063886378 45393.53643423357 43061.93028605361 47588.37456099911 38365.653365703 48092.308811144416 41126.4813694912 34768.87814040362 41874.975047763466 38358.56123927315 1.2385073658660506 1.1834003927070578 1.1226158879485018 1.2406193825715257 1.000184890313941 1.2537568474258998 1.0721591227823253 0.9064176814016096 1.0916722028898742 1.0 15.227260988020902 -7.51883458273722 24.53192896069 0.9972846145485181 1.1662496255140549 0.48598548549748666 0.08084447632909438 112.96450136298913 685261.4126021966 0.03498849346388286 0.020820314971850315 3.0280665606479436e-08 7.51883458273722 0.16896501096553673 QENCGAQQVPAGPGTS(ph)TPPS(ph)SPVR ddPTM_A459_Selumetinib_30min_R1 1 QENCGAQQVPAGPGTSTPPSSPVR 24 0 Q96G46-2;Q96G46 Q96G46-2 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 2 QENCGAQQVPAGPGT(0.397)S(0.49)T(0.194)PPS(0.501)S(0.418)PVR 94.016 6.5893e-05 5325800.0 2446.1 1951.9 1782.3 1608.1 1358.4 1672.8 1518.4 1770.7 1057.6 1720.7 True False 2503.0893707179494 1723.3706405863074 1540.2734494731162 1327.2755227755913 1235.5329598449994 1655.973150780877 1403.8658655291463 1723.7352839557975 1794.6699559521878 1941.5686060373457 1.2892098496723443 0.8876176897522202 0.7933139445516402 0.6836099011121224 0.6363581261064303 0.8529047830870338 0.7230575634380355 0.8878054983974343 0.9243402218039715 1.0 10.923006970966489 -4.748992479653774 2.8482279933787362 0.7969135034004996 1.4013440997474347 0.6389931486406313 0.1063440957560557 0.2987182866085162 3.1313803811888077 0.02791165221032666 0.44128010120113964 1.7824096318086808e-05 4.748992479653774 0.6044305963469351 QENEDSS(ph)DATTPVPR ddPTM_A459_Selumetinib_30min_R2 1 QENEDSSDATTPVPR 15 0 Q6P4R8-3;Q6P4R8;Q6P4R8-2 Q6P4R8-3 NFRKB Nuclear factor related to kappa-B-binding protein 1 QENEDS(0.141)S(0.858)DAT(0.001)TPVPR 211.9 8.691500000000002e-07 4009600.0 14085.0 13507.0 15185.0 16652.0 12454.0 11101.0 12534.0 13646.0 10529.0 12747.0 True False 13302.212086722398 14542.943468149733 14208.013632177928 14383.968873697755 10889.417179827371 12630.061985155293 13116.85583564982 13685.70760078309 12635.094204840267 12378.96098931656 1.074582276994219 1.1748113174199968 1.1477549403734206 1.1619689961145836 0.8796713382670232 1.0202844969020777 1.0596087867931798 1.105561897528742 1.020691010800079 1.0 13.595602608603576 QENEDSSDAT(ph)TPVPR ddPTM_A459_Selumetinib_30min_R2 1 QENEDSSDATTPVPR 15 0 Q6P4R8-3;Q6P4R8;Q6P4R8-2 Q6P4R8-3 NFRKB Nuclear factor related to kappa-B-binding protein 1 QENEDS(0.167)S(0.317)DAT(0.412)T(0.104)PVPR 118.2 0.0047989 5419000.0 13387.0 10653.0 13487.0 13927.0 15017.0 11065.0 11457.0 9913.1 9929.6 11909.0 True False 12643.004132407003 11470.050845206128 12619.261103535302 12030.118574584962 13130.430206316656 12589.103311930754 11989.773201614818 9941.945479797952 11915.79745620496 11565.15622670203 1.0931978681979582 0.9917765588608028 1.091144888678591 1.0402037239072837 1.1353439546281845 1.088537246290249 1.0367151957647072 0.8596464487737439 1.030318762896895 1.0 13.497497134150095 -7.53764287824834 24.94517246070158 0.9566256793018758 1.0710139347882888 0.45092549197967935 0.05411802321109035 195.91729312474442 331013.51350981265 0.024353547478631825 0.014067628841224486 2.899727062503225e-08 7.53764287824834 0.11438825548641296 QENGAS(ph)VILR ddPTM_A459_Selumetinib_30min_R2 2 QENGASVILR 10 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;E9PPR1;E9PMW7;P29692-4;E9PIZ1;H0YCK7;E9PK06;E9PK72 P29692 EEF1D Elongation factor 1-delta 1 QENGAS(1)VILR;QENGAS(1)VILR 120.03 0.0052145 4076300.0 17432.2 16713.8 20804.4 21473.2 21386.0 12861.5 13014.6 15680.8 10222.4 15770.2 True False 16463.388110625634 17995.694716662536 19465.867554118027 18548.513116663857 18699.299486734242 14633.054879927464 13619.80468794066 15726.428531903812 12267.1656377205 15314.87335009962 1.074993422033003 1.1750469171555686 1.2710433256042177 1.211143748475282 1.2209894955881309 0.9554799798479743 0.8893187933449065 1.026872907950069 0.8009968712957528 1.0 13.902645815834102 -6.7899027792642865 6.703673892642845 0.9319250498410943 1.1955895181296043 0.7502851285591364 0.07387188590707375 0.08594270306581617 12.659131124690925 0.025460336033532312 0.022944989215992074 1.6221731948125378e-07 6.7899027792642865 0.2636644682885101 QENGDLS(ph)PFSGTSLR ddPTM_A459_Selumetinib_30min_R1 1 QENGDLSPFSGTSLR 15 0 P19174-2 P19174-2 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1 QENGDLS(0.976)PFS(0.024)GTSLR 191.44 2.8685e-05 5109200.0 1264.9 1512.4 1097.4 1136.0 1076.9 1141.2 1201.7 1124.0 696.49 1202.9 True False 1294.3697089330499 1335.3275049043145 948.3791075867125 937.6189253610293 979.4945851421371 1129.7205641266962 1111.0548015057798 1094.187868733448 1181.8926603830746 1357.3039322382315 0.9536329175725577 0.9838087647048387 0.6987227289784752 0.6907951145583656 0.7216472021317463 0.8323268925212322 0.8185748048881136 0.8061480135323135 0.8707649276710642 1.0 10.406528094907461 -8.67936820657876 1.9513483726473864 0.9999668718812201 0.8081456228840938 0.2707482972066442 0.09275497916977031 0.8973335565295555 6.736971884129318 0.09908116743202565 0.02760413756656135 2.0923377632353823e-09 8.67936820657876 -0.19182124899712638 QENGDLS(ph)PFSGTSLR ddPTM_A459_Selumetinib_30min_R2 2 QENGDLSPFSGTSLR 15 0 P19174-2 P19174-2 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 1 QENGDLS(0.545)PFS(0.455)GTSLR;QENGDLS(0.817)PFS(0.182)GTSLR 194.32 2.2152e-05 10934700.0 28835.0 23251.0 30096.0 33968.0 35880.0 30520.0 32464.0 31924.0 29186.0 33377.0 True False 27232.46613565072 25034.276936251536 28159.656126047208 29341.499801931634 31372.43362873023 34723.852967024526 33973.64032619563 32016.89355469731 35024.01552497559 32413.319286139365 0.8401628322988788 0.7723453656582692 0.8687680480193488 0.9052297156890899 0.967887100724848 1.0712834640750044 1.0481382676757667 0.9877696656753209 1.0805439336770615 1.0 14.984299146963915 -6.082766509174925 1.3288720460956904 1.037871774023763 0.8085379082352989 0.8767157861693976 0.034702148736742676 0.1355111557542086 0.48495604636277273 0.012660352294291652 0.02135340972055163 8.264821738234565e-07 6.082766509174925 -0.22933386578846415 QEPCAQHNGSEPAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 QEPCAQHNGSEPASPK 16 0 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 QEPCAQHNGS(0.001)EPAS(0.999)PK;QEPCAQHNGS(0.001)EPAS(0.999)PK 119.5 0.0011103 6379300.0 4605.8 3972.2 3767.8999999999996 3681.9 3995.3 3337.3 4220.2 4341.0 1980.26 4020.2 True False 4713.10617867329 3507.1329773743205 3256.2398755931968 3038.925282822864 3633.9258204275056 3303.7297920259557 3901.8669162974884 4225.862578444749 3360.3565875320332 4536.231830064128 1.0389914702852965 0.7731379499016346 0.717829246294752 0.6699228338997619 0.801089088159794 0.7282982695307376 0.8601559758118289 0.9315799405219128 0.7407814929698001 1.0 12.147278657644431 -10.36344517436197 5.5332011454456005 1.0000000760898025 0.801981532537809 0.23125797990097696 0.10530063996366146 1.0112842113465691e-07 2.135770666147939e-08 0.10435114123058097 0.025308859456219003 4.330667349337154e-11 10.36344517436197 -0.19801854355199344 QEPCAQHNGSEPAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QEPCAQHNGSEPASPK 16 0 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 QEPCAQHNGSEPAS(1)PK;QEPCAQHNGS(0.005)EPAS(0.995)PK 126.29 0.0007497000000000001 6540200.0 46733.0 37664.0 40215.0 46003.0 39928.0 35681.0 48450.0 48870.0 34189.0 32101.0 True False 44135.7669470215 40552.707691152114 37627.610682781386 39737.312040398654 34911.88767915106 40595.73387013113 50703.021001853675 49012.203609135955 41027.75532047529 31174.16072158552 1.4157804388446982 1.30084360741339 1.2070127891759854 1.2746874693849854 1.1198982385106355 1.3022237946576685 1.626443818477719 1.5722060345701327 1.316082113224847 1.0 14.92806309953686 -7.01922436750782 24.266219646398678 1.4317907006892439 1.257966666975064 0.05584773009402877 0.17496296211385443 906.8876295111351 1144728.9758405234 0.06407968685132845 0.05049051981339662 9.566996883571972e-08 7.01922436750782 -0.17382403371417987 QEPCAQHNGSEPAS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 1 QEPCAQHNGSEPASPKR 17 1 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 QEPCAQHNGS(0.014)EPAS(0.986)PKR 69.259 0.023843 34830000.0 1554.4 1787.3 2159.2 2145.3 2170.7 1757.5 2087.9 1716.3 792.34 1661.7 True False 1590.614495664111 1578.0420851067722 1865.9924996366235 1770.6636272685005 1974.3605682682112 1739.821145682324 1930.4080220220671 1670.7781486719002 1344.5431097760559 1874.99538132868 0.848329820704386 0.8416245185566924 0.9951984512699563 0.9443562607678283 1.0529948969096223 0.9279068967356243 1.0295534811686415 0.8910838742908982 0.7170914249523489 1.0 10.872671326487984 -10.500322409849636 5.136622024787498 1.0000004231090425 0.9243275663457713 0.05996442837568172 0.09472688660586237 2530003457783.037 503751347590.3018 13163474.427132623 0.023752340494636044 3.159930931954145e-11 10.500322409849636 -0.07567285676327118 QEPCAQHNGSEPAS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 3 QEPCAQHNGSEPASPKR 17 1 Q8N6T7-2;Q8N6T7;M0QZ09 Q8N6T7-2 SIRT6 NAD-dependent protein deacetylase sirtuin-6 1 QEPCAQHNGS(0.009)EPAS(0.991)PKR;QEPCAQHNGSEPAS(1)PKR;QEPCAQHNGSEPAS(1)PKR 121.14 0.00073892 20165100.0 37099.0 38034.3 40325.3 45637.5 40357.6 30424.4 35014.6 33828.6 29826.6 39851.0 True False 35037.18609906381 40951.40851044992 37730.81410086694 39421.59377092128 35287.517486478326 34615.08493479495 36642.848280113656 33927.03562537381 35792.75342483513 38700.3980846673 0.9053443332135951 1.0581650457666596 0.9749464080013043 1.0186353557572243 0.9118127779791205 0.8944374385779016 0.9468338852729057 0.8766585695358867 0.9248678358948419 1.0 15.240060786017883 -6.270276804907549 24.63553621382981 0.9190880671647707 0.9931703490792727 0.29147131771639734 0.04767506931624162 555.4312297244026 1548337.9036731718 0.01374324389906418 0.015815515747308044 5.366896191616048e-07 6.270276804907549 0.07408228191450206 QEPES(ph)EEEEEEKQEK ddPTM_A459_Selumetinib_30min_R1 4 QEPESEEEEEEKQEK 15 1 P49756 P49756 RBM25 RNA-binding protein 25 1 QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK 132.9 0.00032135 250746000.0 13939.1 14269.4 13429.399999999998 12469.900000000001 10474.5 13712.3 14334.099999999999 16016.7 10045.5 15641.1 True False 14263.853909232885 12598.732014335916 11605.761242413882 10292.266054013646 9527.083324423178 13574.366711772254 13252.867296549879 15591.885086426173 17046.47980570887 17648.787542215818 0.8082058824218838 0.7138582174101086 0.657595385215724 0.5831712818455428 0.5398151743644961 0.7691387682752955 0.7509222525824555 0.8834536111407345 0.9658725714122723 1.0 14.107281454438782 -7.78511763286255 1.315335676267847 0.9955783349435113 0.6649489977509496 0.7447951821523459 0.0731306339281635 0.24541119722521634 0.7755415025940462 0.0672905046362054 0.025712248631768846 1.6401454637609955e-08 7.78511763286255 -0.3306293371925617 QEPES(ph)EEEEEEKQEK ddPTM_A459_Selumetinib_30min_R2 6 QEPESEEEEEEKQEK 15 1 P49756 P49756 RBM25 RNA-binding protein 25 1 QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK;QEPES(1)EEEEEEKQEK 136.43 0.00022313 622522400.0 956732.0 727835.0 686884.0 801246.0 689329.0 643360.0 868472.0 775984.0 528183.0 657842.0 True False 903560.6655416471 783657.6041416135 642690.6312627519 692114.9125735543 602729.3283405507 731977.0001594012 908857.6688446202 778241.9849689341 633834.3586660802 638848.3921812183 1.4143585185471352 1.2266722648639272 1.006014320656604 1.0833789691642932 0.9434622294072833 1.1457757569995821 1.4226500058042097 1.218195106215709 0.9921514500521498 1.0 19.285114074154613 -2.5379260833249084 0.01565546870116046 6.896584431260232e-07 2.4905662484749125 0.11864714772570206 0.15420140975912486 14307.232847759306 20.616512518235027 1347.2179203282408 1988.286372702806 0.0028978367559078866 2.5379260833249084 2.4905655588164692 QEPES(ph)EEEEEEKQEKEEK ddPTM_A459_Selumetinib_30min_R1 4 QEPESEEEEEEKQEKEEK 18 2 P49756 P49756 RBM25 RNA-binding protein 25 1 QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK 107.34 0.0018052 112525000.0 5415.61 5822.17 9213.2 8934.84 5325.049999999999 6665.719999999999 5261.1 4926.219999999999 4568.5199999999995 5925.709999999999 True False 5541.783176057324 5140.507629746597 7962.098044485055 7374.53792171896 4843.400167713937 6598.668908789513 4864.25099126409 4795.56064298228 7752.444768501033 6686.332599803312 0.8288225411072646 0.7688082447316203 1.1908019718790643 1.1029271744477522 0.7243732039079857 0.9868891219954601 0.7274916284312836 0.7172183811381665 1.1594464757450267 1.0 12.706999405718546 -6.256287257052571 24.963371422977758 0.8688927801467262 0.9738349881234281 0.05083080430410081 0.17499230389072903 1284.9176091335225 6225753.124003627 0.053728856162981856 0.06722955723661253 5.542589860572248e-07 6.256287257052571 0.10494220797670184 QEPES(ph)EEEEEEKQEKEEK ddPTM_A459_Selumetinib_30min_R2 5 QEPESEEEEEEKQEKEEK 18 2 P49756 P49756 RBM25 RNA-binding protein 25 1 QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK;QEPES(1)EEEEEEKQEKEEK 96.773 0.004156100000000001 185868000.0 534158.0 594847.0 487283.0 443834.0 335985.0 240172.0 265114.0 230662.0 153583.0 433842.0 True False 504471.6367638952 640469.8521654311 455931.74229361466 383383.0435436451 293775.5605559899 273253.5129356556 277442.3263134248 231333.18823185028 184303.89146756456 421315.85420311143 1.1973715959919595 1.5201655617181407 1.0821613707273767 0.909965859862517 0.6972810484705001 0.6485716362430626 0.6585138526015997 0.5490730669734714 0.4374482698168624 1.0 18.68454268027253 -5.8094876196666 1.4429403874081757 0.6317757825308111 1.3703200620611427 0.748328857988241 0.15920213956508292 0.18672629670020002 0.7863069946129195 0.05111704998460314 0.11266706601496929 1.550644990046038e-06 5.8094876196666 0.7385442795303315 QEPGGS(ph)HGSETEDTGR ddPTM_A459_Selumetinib_30min_R1 1 QEPGGSHGSETEDTGR 16 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 QEPGGS(0.869)HGS(0.05)ET(0.08)EDTGR 175.19 1.6151e-06 11675000.0 877.08 742.58 633.23 818.64 863.99 646.21 868.42 719.37 292.82 800.3 True False 897.5142574994065 655.638388383924 547.2408440834101 675.6798917760152 785.8422570498235 639.7097141117349 802.914380231047 700.2899707569217 496.8941532733733 903.02630058214 0.993896032619227 0.7260457286363241 0.6060076475409729 0.7482394381430918 0.8702318598508445 0.7084065145160702 0.8891373149524489 0.7754923309603237 0.5502543535587482 1.0 9.818624196491784 QEPGGS(ph)HGSETEDTGR ddPTM_A459_Selumetinib_30min_R2 1 QEPGGSHGSETEDTGR 16 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 QEPGGS(0.886)HGS(0.018)ET(0.092)EDT(0.005)GR 208.49 6.2351e-08 19727000.0 11417.0 9172.5 11839.0 13872.0 13447.0 9210.5 7889.0 9789.1 10294.0 9554.6 True False 10782.488845872176 9876.001255763927 11077.29162932858 11982.609669465242 11757.667642294733 10479.162770405617 8255.854131756938 9817.58466032725 12353.08763839165 9278.733872167883 1.1620646733079496 1.0643694917673612 1.1938365494623764 1.291405684713924 1.2671629345424553 1.1293742136347389 0.8897608494323634 1.0580737410494854 1.3313333272167094 1.0 13.179712240772961 -6.9998053597513445 24.999348806340077 1.0653366138829847 1.19413335797969 0.20289877594904282 0.11771367686456448 11.793203034995933 1514420.190444961 0.04396097130662243 0.03840337486577525 1.0004482761808006e-07 6.9998053597513445 0.12879674409670527 QEPGGSHGS(ph)ETEDTGR ddPTM_A459_Selumetinib_30min_R2 1 QEPGGSHGSETEDTGR 16 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 QEPGGS(0.369)HGS(0.452)ET(0.176)EDT(0.003)GR 145.05 0.00038688 14318000.0 2512.5 2883.2 5977.7 5295.8 3964.4 3232.4 2539.9 4853.1 3374.3 3201.3 True False 2372.865308334399 3104.3321690508105 5593.101290027654 4574.502904235443 3466.356629814329 3677.6337591943043 2658.010382716371 4867.2217175260475 4049.2542858194042 3108.870151023698 0.7632564864611843 0.998540311511115 1.7990784491870595 1.4714358213800396 1.1149891958893545 1.1829486535432567 0.8549763269595334 1.565591832750993 1.3024842110198953 1.0 11.602174645185933 -5.009639436307299 23.43331929961606 1.2954024792454946 0.8220767791290013 0.29426774153358015 0.26222549854030175 239.28567966756012 581726.78648682 0.0683896945030259 0.21670521235527393 9.780488881179056e-06 5.009639436307299 -0.4733257001164932 QEPIES(ph)DEEEAEPPR ddPTM_A459_Selumetinib_30min_R2 2 QEPIESDEEEAEPPR 15 0 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 QEPIES(1)DEEEAEPPR;QEPIES(1)DEEEAEPPR 165.17 8.835e-05 5967700.0 10336.6 9595.1 10731.1 12164.0 10070.3 9844.1 10149.7 10327.4 11234.0 8786.5 True False 9762.133152688297 10331.013316890761 10040.672709138267 10507.242215929593 8805.178884375744 11200.035419157486 10621.681161249002 10357.451024206894 13481.113904186122 8532.810914931346 1.1440700198343539 1.2107397456578801 1.1767133725614796 1.2313928341647933 1.0319200755952282 1.3125845082959513 1.2448044691418623 1.213838104168306 1.5799147594605512 1.0 13.058805363251667 -6.813707465469481 24.99987415184075 1.282004399396244 1.1668514981483182 0.13013121177204112 0.14147697541978232 200.97161333828583 96123.29049458935 0.04733680086371996 0.04174715745980082 1.5356510269954332e-07 6.813707465469481 -0.11515290124792577 QEPIES(ph)DEEEAEPPREVEPGQR ddPTM_A459_Selumetinib_30min_R1 2 QEPIESDEEEAEPPREVEPGQR 22 1 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 QEPIES(1)DEEEAEPPREVEPGQR;QEPIES(1)DEEEAEPPREVEPGQR 83.73299999999998 0.00041036 69408000.0 3557.4 3976.0 4902.6 4839.6 4929.5 3454.7799999999997 4038.53 3859.67 2258.99 3123.84 True False 3640.2804985045705 3510.488071607749 4236.853848054146 3994.4547105433458 4483.627595373912 3420.0280498892594 3733.9004306608426 3757.299013624933 3833.3410398982933 3524.815292778351 1.0327578032139118 0.9959353271077905 1.2020073382950367 1.133238022068048 1.2720177436133968 0.970271564838084 1.0593180409512142 1.0659562846662902 1.0875296211271128 1.0 11.783331944109829 -6.816589390855477 24.9999975746481 1.042156513710338 1.1243965781851257 0.2448582286593275 0.07915690725605284 157.26029556731305 71286.08887312972 0.02958359937510425 0.026090297420895144 1.5254943699063443e-07 6.816589390855477 0.08224006447478782 QEPIES(ph)DEEEAEPPREVEPGQR ddPTM_A459_Selumetinib_30min_R2 1 QEPIESDEEEAEPPREVEPGQR 22 1 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 QEPIES(1)DEEEAEPPREVEPGQR 48.84 0.034625 69237000.0 4071.5 2413.0 8403.4 7994.1 10842.0 1981.7 6866.3 2923.0 4508.7 2151.7 True False 3845.222329505871 2598.069340982104 7862.734392930125 6905.2897894083135 9479.931031290214 2254.6611869184976 7185.596555315331 2931.5054460713013 5410.5659836036975 2089.574830212006 1.8401936479660501 1.2433483134549945 3.762839348582879 3.304638670780558 4.536775086599024 1.079004759398706 3.4387840298527563 1.4029195813838713 2.5893142975189587 1.0 11.028993708908773 -7.7737978151312435 24.996441400982565 1.7470875910432035 2.7516676528828476 0.16502813293794183 1.1079952815909817 483.27065450305196 977458.7872117413 0.613738950105703 0.2981429482068339 1.6834576087621256e-08 7.7737978151312435 1.004580061839644 QEPLEEDS(ph)PSSSSAGLDK ddPTM_A459_Selumetinib_30min_R1 2 QEPLEEDSPSSSSAGLDK 18 0 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 QEPLEEDS(0.975)PS(0.025)S(0.001)SSAGLDK;QEPLEEDS(0.338)PS(0.317)S(0.317)S(0.029)SAGLDK 314.02 8.315099999999996e-112 48940000.0 3946.8999999999996 4010.9 5146.6 4598.200000000001 4578.9 4029.3999999999996 3989.3 3964.4 2684.55 3689.6000000000004 True False 4038.855090669505 3541.3019633831796 4447.719988250206 3795.2106889041256 4164.739303470453 3988.8678944024796 3688.383889196143 3859.2512338139527 4555.485278225648 4163.196099747425 0.9701332807538267 0.8506209841035413 1.0683426583052484 0.9116098780776566 1.0003706776443033 0.9581263526463426 0.8859500731709256 0.9269924215311615 1.0942278886411385 1.0 12.023475800255278 -8.251602650401749 24.945610698856573 1.0471139462838477 0.9463819847369294 0.30247227146646494 0.06110477070447547 696.9072573711735 1767343.5845460377 0.0407132914070286 0.014967286409550957 5.602699755814515e-09 8.251602650401749 -0.10073196154691832 QEPLEEDS(ph)PSSSSAGLDK ddPTM_A459_Selumetinib_30min_R2 1 QEPLEEDSPSSSSAGLDK 18 0 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 QEPLEEDS(0.794)PS(0.177)S(0.022)S(0.005)S(0.001)AGLDK 150.68 0.00013859 33081000.0 53158.0 49389.0 58851.0 58101.0 57968.0 41476.0 47151.0 46891.0 37025.0 47367.0 True False 50203.691168334306 53176.977489334946 55064.59073212398 50187.54357018456 50685.54159950484 47188.94251835877 49343.614927934024 47027.44504677708 44431.034564935995 45999.39163575408 1.0913990247060645 1.156036538709393 1.1970721519134997 1.0910479853210742 1.1018741726164123 1.0258601438041646 1.0727014678511655 1.0223492827723384 0.9659048301499917 1.0 15.489327160504219 -6.880707673392815 0.7402847600004636 0.9926061472716408 1.1495323492182856 0.7257494568529193 0.03527418177012197 0.36671780016057687 0.4320156708776077 0.026988247433427533 0.023717663726560884 1.316110417099255e-07 6.880707673392815 0.15692620194664486 QEPLEEDSPSS(ph)SSAGLDK ddPTM_A459_Selumetinib_30min_R2 1 QEPLEEDSPSSSSAGLDK 18 0 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 QEPLEEDS(0.22)PS(0.22)S(0.383)S(0.088)S(0.088)AGLDK 124.84 0.0008547 41816000.0 79072.0 69856.0 84009.0 85491.0 88285.0 66700.0 76031.0 75360.0 62510.0 74336.0 True False 74677.49479029547 75213.73057755751 78603.95240208336 73846.97831979931 77193.84902208597 75887.31955768462 79566.59215256832 75579.28512348031 75013.74667533154 72189.72653187704 1.0344615276706985 1.0418896731011325 1.0888523364522509 1.0229568924491004 1.0693190392956988 1.0512204880589875 1.1021871944262576 1.0469534759922734 1.0391194187750177 1.0 16.139505918377942 -5.016949144411883 24.124339430496118 1.056173520842938 1.0363185381273095 0.03050982257647117 0.02832068024148286 1151.9322739073878 1639614.4954152114 0.006809421068004994 0.019102411481969905 9.617248891198876e-06 5.016949144411883 -0.019854982715628466 QEPLGS(ph)DSEGVNCLAYDEAIMAQQDR ddPTM_A459_Selumetinib_30min_R1 2 QEPLGSDSEGVNCLAYDEAIMAQQDR 26 0 J3KR44;F5H6Q1;F5GYJ8;Q96FW1;F5H3F0 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 QEPLGS(0.681)DS(0.319)EGVNCLAYDEAIMAQQDR;QEPLGS(0.984)DS(0.016)EGVNCLAYDEAIMAQQDR 178.17 1.2982e-21 35412000.0 3074.8 3439.6 3543.6 3907.8999999999996 3728.6000000000004 3394.2 3376.8999999999996 3225.3 2031.54 2587.5 True False 3146.4368574807054 3036.8900329733406 3062.3985836014886 3225.4586253682833 3391.3487883377948 3360.057429687021 3122.1777142422106 3139.754566749101 3447.3750021890223 2919.6308293843394 1.077683118637363 1.0401623391590666 1.0488992487612738 1.1047487897805333 1.1615676729420363 1.150850099221467 1.06937414238107 1.0753943735452263 1.1807571585740406 1.0 11.511570244764918 -5.8003239157488995 6.004370182653552 1.1122311015765136 1.0539486675389746 0.1685781994433152 0.05021959190055519 0.27702648072512953 25.77499016009545 0.013882527495954831 0.02131636057772143 1.5837115507714771e-06 5.8003239157488995 -0.058282434037538966 QEPLGS(ph)DSEGVNCLAYDEAIMAQQDR ddPTM_A459_Selumetinib_30min_R2 1 QEPLGSDSEGVNCLAYDEAIMAQQDR 26 0 J3KR44;F5H6Q1;F5GYJ8;Q96FW1;F5H3F0 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 QEPLGS(0.735)DS(0.265)EGVNCLAYDEAIMAQQDR 82.042 8.2246e-05 3315400.0 15182.0 9113.6 9687.5 18054.0 12970.0 11906.0 9845.6 10729.0 7124.0 13846.0 True False 14338.245218361333 9812.583815157277 9064.216796952498 15595.014055112868 11340.592646728837 13545.943428092869 10303.439908686285 10760.219613718433 8548.99906119119 13446.23000377164 1.0663394285490793 0.7297646858937313 0.6741084151029697 1.1598056890844868 0.8434031430034905 1.007415716099848 0.7662697950128915 0.8002406333002049 0.6357915236310263 1.0 13.714914112385848 -10.42833188696272 4.508960238625897 1.000001596716485 0.853836034533847 0.06701431468463714 0.16378343162988268 228152676.82626927 593937983.7219334 6536.17171377889 0.040751252890931296 3.729650297427578e-11 10.42833188696272 -0.146165562182638 QEPQS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 QEPQSPSR 8 0 Q8WUQ7-2;Q8WUQ7;K7ENY9 Q8WUQ7-2 CACTIN Cactin 1 QEPQS(0.986)PS(0.014)R 103.21 0.015596 12575000.0 44245.0 36931.0 40100.0 47129.0 48605.0 46428.0 72253.0 81759.0 65731.0 69482.0 True False 41786.040026768365 39763.4889481186 37520.009657578834 40709.948897940274 42498.80536578685 52823.035568578474 75612.90766660338 81996.90515406898 78879.03667759086 67475.87412408342 0.6192737859153444 0.5892993527582365 0.5560507387956495 0.6033259950523578 0.6298370479444922 0.7828432940555998 1.1205917470228919 1.215203303676843 1.1689961442001895 1.0 16.042084140923855 -7.111485375227462 2.256615522680882 1.154571393304367 0.5947446619120568 0.9512655761641868 0.0561822499529511 0.05865059870506308 0.5867206517108842 0.024905324071186806 0.018161727207248415 7.735967290384799e-08 7.111485375227462 -0.5598267313923103 QEPS(ph)PKPNNK ddPTM_A459_Selumetinib_30min_R1 3 QEPSPKPNNK 10 1 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38;C9J286;C9J323;J3QT54 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 QEPS(1)PKPNNK;QEPS(1)PKPNNK;QEPS(1)PKPNNK 130.15 0.01342 18220400.0 5347.41 6005.72 5736.06 4919.33 3966.07 5692.549999999999 4542.2300000000005 5727.889999999999 6757.23 5524.82 True False 5471.994248751428 5302.567510416517 4957.134557922217 4060.2613627608066 3607.3396687665295 5635.288115421852 4199.605934129645 5575.967750391131 11466.525781447437 6233.984463304035 0.877768348792331 0.8505904276197276 0.7951791646421457 0.6513107927460013 0.5786571477681589 0.9039624895752674 0.6736632018976574 0.8944468474719052 1.8393574525160328 1.0 12.605938844061981 -8.084818894798362 7.055965525673839 1.4141439255585344 0.7619770020427594 0.5999557705923193 0.21188678541907893 0.16187374974855984 11.526588218446852 0.13380373351910307 0.050097100971198544 8.225856049705204e-09 8.084818894798362 -0.652166923515775 QEPS(ph)PKPNNK ddPTM_A459_Selumetinib_30min_R2 2 QEPSPKPNNK 10 1 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38;C9J286;C9J323;J3QT54 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 QEPS(1)PKPNNK;QEPS(1)PKPNNK 83.617 0.021834 21674000.0 212459.0 156728.0 137718.0 159867.0 136036.0 141319.0 290940.0 423060.0 213861.0 350540.0 True False 200651.37932076346 168748.53364005138 128857.37381602102 138092.83881404295 118945.94150272965 160784.4094838448 304469.2864866729 424291.03455864696 256639.17577560467 340418.999387701 0.5894247374020476 0.4957083298628252 0.3785257992291617 0.40565549826074754 0.34941040810493335 0.4723132662191057 0.894395691880625 1.2463788311516204 0.7538920455004334 1.0 18.376952033074943 -7.3053569232593025 3.821015952724715 1.009863693596704 0.43769381989889056 0.8041247237393819 0.12756387765235955 0.09265735098325902 2.8758162461345873 0.05401835894958095 0.0363201262243274 4.950431742353883e-08 7.3053569232593025 -0.5721698736978135 QEPS(ph)SPPLAPGLPAFLAAPGTTSCPECGK ddPTM_A459_Selumetinib_30min_R2 1 QEPSSPPLAPGLPAFLAAPGTTSCPECGK 29 0 Q8N0Y2-2;Q8N0Y2 Q8N0Y2-2 ZNF444 Zinc finger protein 444 1 QEPS(0.5)S(0.5)PPLAPGLPAFLAAPGTTSCPECGK 64.847 0.007238600000000001 0.0 12076.0 5583.6 7492.7 11003.0 8965.4 10044.0 7745.0 11366.0 5960.1 10186.0 True False 11404.86426405819 6011.844165896262 7010.627839434934 9504.372418766297 7839.08630030707 11427.469829645946 8105.15784642635 11399.073178257402 7152.286539108032 9891.903713593665 1.1529493810564877 0.6077540117616246 0.7087238253037966 0.960823385867089 0.7924749903837449 1.1552346404203342 0.8193729014252402 1.1523639441205389 0.7230444964076235 1.0 13.272032481466667 QEQALLEEIER ddPTM_A459_Selumetinib_30min_R2 1 QEQALLEEIER 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 134.99 0.021256 1233800.0 4133.6 3735.0 5860.4 5176.3 4609.4 4738.4 4793.8 5944.0 4357.2 5136.5 False True 3903.8710601118682 4021.4624900821227 5483.348244321071 4471.279010384444 4030.3259634411647 5391.0715890874535 5016.721198734494 5961.296055917824 5228.761750340019 4988.195898770256 0.782621841510734 0.8061957813392088 1.0992648154962972 0.8963719751838038 0.807972670927933 1.0807658116267085 1.005718560486221 1.1950805816161847 1.048227025652515 1.0 12.284302409138943 -6.775885093211662 24.980811735965442 1.0743859982389974 0.8877285508875309 0.47979077300688855 0.09716944148730448 221.64787142110964 383290.81030150084 0.03558031670017865 0.031518643959728906 1.675386095495932e-07 6.775885093211662 -0.1866574473514665 QEQDEDGTEEDNSR ddPTM_A459_Selumetinib_30min_R2 2 QEQDEDGTEEDNSR 14 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 0 ; 279.77 2.058e-53 4165500.0 10900.4 8167.799999999999 10145.2 10600.4 12886.400000000001 9379.9 10141.4 9847.3 8629.5 9904.9 False True 10294.599405758518 8794.243996383606 9492.468877258572 9156.60723329004 11267.495226122326 10671.896082745527 10612.995194802867 9875.95401269172 10355.641128375828 9618.919800979169 1.0702448527235424 0.9142652375049832 0.9868539372053269 0.9519371637091655 1.1713888315167509 1.1094692859024742 1.1033458448964826 1.026721733524214 1.0765908587076132 1.0 13.231659173951497 -6.239017063210081 24.986610961428003 1.0851043330328658 0.9765016167274085 0.42545317426216134 0.05697975458024775 725.7184370765887 808714.1043182863 0.016583694556468777 0.02139177399831038 5.767438029753867e-07 6.239017063210081 -0.10860271630545726 QEQINTEPLEDT(ph)VLSPTK ddPTM_A459_Selumetinib_30min_R2 1 QEQINTEPLEDTVLSPTK 18 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 QEQINTEPLEDT(0.585)VLS(0.415)PTK 162.81 1.5623e-05 14002000.0 114440.0 130900.0 121290.0 109200.0 123230.0 87680.0 93834.0 89476.0 86357.0 114780.0 True False 108079.88293961725 140939.60909016035 113486.33345056676 94326.77161949303 107748.74570982237 99757.12412020692 98197.46692854358 89736.3603464509 103630.81301618324 111466.00316574523 0.9696219463337806 1.2644178950292952 1.0181250805397353 0.8462380361771212 0.966651199914332 0.894955603385835 0.880963380220318 0.8050558717263481 0.9297078039309313 1.0 16.766244233523764 -5.5418218785588556 5.701278233903676 0.8981174704410742 1.123664021801364 0.51102240578851 0.08451368501746902 0.10824306362153709 11.410561867986262 0.02155114253811282 0.03954319196180693 2.871958244813694e-06 5.5418218785588556 0.2255465513602899 QEQINTEPLEDTVLS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 4 QEQINTEPLEDTVLSPTK 18 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 QEQINTEPLEDT(0.001)VLS(0.919)PT(0.08)K;QEQINTEPLEDTVLS(0.764)PT(0.236)K;QEQINTEPLEDTVLS(0.942)PT(0.058)K;QEQINTEPLEDT(0.003)VLS(0.92)PT(0.077)K 297.29 1.0984999999999993e-111 99968000.0 18437.2 21800.6 22826.9 23571.0 19242.9 19321.699999999997 19341.199999999997 16881.5 10862.599999999999 15427.699999999999 True False 18866.75088745389 19248.17561717603 19727.132359186384 19454.767332469048 17502.383092609933 19127.34124069994 17882.277712310544 16433.74778115987 18433.038827086075 17407.995573523775 1.0837980057938876 1.1057088988723682 1.1332225054784504 1.1175765325939222 1.0054220785321035 1.098767584120435 1.0272450746430632 0.9440344646085698 1.0588834739320196 1.0 14.087462474404285 -6.809775770368268 0.9184964136746837 1.0008500791203954 1.1107962266875264 0.5055226222978512 0.040925366109422275 0.4610091766795521 0.8363499476414344 0.02564813030967187 0.022522611311606308 1.5496164914975705e-07 6.809775770368268 0.10994614756713106 QEQINTEPLEDTVLS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 3 QEQINTEPLEDTVLSPTK 18 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 QEQINTEPLEDT(0.021)VLS(0.976)PT(0.003)K;QEQINTEPLEDT(0.001)VLS(0.99)PT(0.009)K;QEQINTEPLEDT(0.004)VLS(0.986)PT(0.009)K 153.17 7.6392e-05 235808000.0 332842.0 327287.0 329662.0 336879.0 352976.0 263323.0 296290.0 295505.0 240030.0 320822.0 True False 314343.9741120944 352388.8605064287 308451.9058288468 290995.49905131024 308631.9992345231 299593.3530418024 310068.0720874967 296364.870626514 288042.706998557 311559.0352643378 1.0089387195765123 1.1310500438783597 0.9900271567060965 0.9339979461819148 0.9906051961313487 0.9615941735973625 0.9952145083015291 0.9512318279425519 0.9245204741187215 1.0 18.249146030345635 -5.446310501862331 6.771633474412701 0.9651372045254221 1.0690923072657728 0.5659239943842833 0.03614563386336309 0.15816391282095232 11.739620283301248 0.008884351577741256 0.018578744273951342 3.578405050638376e-06 5.446310501862331 0.10395510274035069 QEQINTEPLEDTVLS(ph)PTKK ddPTM_A459_Selumetinib_30min_R1 4 QEQINTEPLEDTVLSPTKK 19 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 QEQINTEPLEDTVLS(0.981)PT(0.019)KK;QEQINTEPLEDT(0.016)VLS(0.849)PT(0.135)KK;QEQINTEPLEDTVLS(0.992)PT(0.007)KK;QEQINTEPLEDTVLS(0.998)PT(0.001)KK 164.27 1.8944000000000006e-07 83047300.0 9854.699999999999 11288.8 12959.5 14247.8 10465.8 11271.5 10566.2 10949.2 6334.27 9913.2 True False 10084.295336091802 9967.102047979257 11199.671081437953 11759.689194329998 9519.170237887065 11158.118943703157 9769.183027103581 10658.791647986001 10748.793553223586 11185.65578274506 0.9015381424169863 0.8910610375973184 1.0012529706764723 1.0513187087761489 0.8510158387469148 0.9975382007477487 0.8733670351427654 0.9528982345789867 0.9609444240010161 1.0 13.449362219476232 -8.601240022734903 2.3355994502094886 0.9996466461203026 0.940971234396401 0.08640944870179668 0.05987190496132482 1.0683679062474096 13.300123893736313 0.05758541852085975 0.015711407252750265 2.50472457735741e-09 8.601240022734903 -0.05867541172390167 QEQINTEPLEDTVLS(ph)PTKK ddPTM_A459_Selumetinib_30min_R2 1 QEQINTEPLEDTVLSPTKK 19 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 QEQINTEPLEDT(0.007)VLS(0.977)PT(0.017)KK 84.291 0.0020794 43953000.0 59696.0 61993.0 50397.0 62540.0 59679.0 54936.0 54804.0 52859.0 49467.0 66083.0 True False 56378.33530202201 66747.66376108727 47154.51188810477 54021.94411248246 52181.59048297075 62502.935340644166 57352.494592065814 53012.810938721464 59361.78222346225 64175.01208574611 0.8785091497402956 1.0400880590704644 0.7347799455822501 0.8417909456768339 0.8131138395930397 0.9739450497824943 0.8936888787092937 0.8260662400482216 0.9249983801194652 1.0 15.969724042045419 -6.751972671887719 24.999433911533043 0.910990678446794 0.8634169466045543 0.11094526596575993 0.08401171004932519 632.8638181493347 1671248.653510513 0.028813291579573033 0.0284518020524709 1.7702203464661913e-07 6.751972671887719 -0.047573731842239786 QEQLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 QEQLSPK 7 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 QEQLS(1)PK;QEQLS(1)PK 90.827 0.029139 140756000.0 16115.1 17517.7 20926.0 19879.3 14744.099999999999 16634.1 16168.0 15941.1 12008.3 16382.0 True False 16490.550475473938 15466.71954024221 18084.36413829009 16407.753435677398 13410.498758282285 16466.776056554387 14948.434743068525 15518.29024400958 20377.208048468856 18484.789274192943 0.8921146046548007 0.8367268520521176 0.978337587193277 0.8876354061868942 0.725488322282635 0.8908284434458794 0.808688404359491 0.8395167515203994 1.1023770812966727 1.0 14.174050976506594 -8.25532449685417 24.99594237417538 1.0511885478397247 0.856857133136191 0.5793007186936913 0.06605027649191425 316.1779612994003 1292460.9503460103 0.048084720606927006 0.017146894218859777 5.554890509639489e-09 8.25532449685417 -0.19433141470353366 QEQLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 QEQLSPK 7 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 QEQLS(1)PK;QEQLS(1)PK;QEQLS(1)PK;QEQLS(1)PK 117.02 0.011896 242608000.0 1822970.0 1591640.0 1516430.0 1583780.0 1434990.0 1103395.0 1437220.0 1372860.0 1008076.0 1434900.0 True False 1721656.6253271063 1713713.6700707653 1418864.5447641467 1368066.4318271095 1254713.7272266308 1255377.6456274588 1504053.577797402 1376854.7953107918 1209719.3679968254 1393470.7086820658 1.2355169108329778 1.2298167872445507 1.0182234444713216 0.9817690628897514 0.900423467396261 0.9008999168807686 1.0793578712680114 0.9880758789777582 0.8681340486453202 1.0 20.410251246051317 -5.328462205707991 2.698023027113471 0.9600420779237643 1.2447361771814753 0.7785590807658014 0.057329884311554835 0.1286703401133061 1.8024281226398613 0.016503341620292527 0.046558484611932245 4.693942813769042e-06 5.328462205707991 0.28469409925771105 QEQPSIESTS(ph)PISR ddPTM_A459_Selumetinib_30min_R2 1 QEQPSIESTSPISR 14 0 Q5T5P2-3;Q5T5P2 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 QEQPS(0.021)IES(0.022)T(0.372)S(0.547)PIS(0.037)R 87.647 0.037084 0.0 24240.0 19849.0 26187.0 24420.0 26581.0 17727.0 23362.0 21816.0 23158.0 20958.0 True False 22892.83784040829 21371.354475405635 24502.156930249803 21093.953873150323 23241.657142844982 20168.733340315994 24448.379290924786 21879.480948166783 27790.247088583073 20352.888084576465 1.1247955447539955 1.0500403867302237 1.203866342134396 1.0364108418173557 1.1419341101009464 0.9909519109280601 1.2012240812866213 1.0750062034069345 1.3654203262505376 1.0 14.312945907685153 -7.325838714387707 24.99999358902028 1.166663174304011 1.0943734432082368 0.09421245600730233 0.10395857236934875 493.9067678718991 191733.19562172552 0.0404152166990194 0.027247934157239903 4.722383856882041e-08 7.325838714387707 -0.07228973109577419 QEQS(ph)PNANNDQPEDLIQGCSESDSSVLR ddPTM_A459_Selumetinib_30min_R2 1 QEQSPNANNDQPEDLIQGCSESDSSVLR 28 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 QEQS(1)PNANNDQPEDLIQGCSESDSSVLR 72.107 0.00020376 1404200.0 3041.9 1368.3 3107.3 3033.3 2028.4 3098.4 5035.8 3905.8 4489.1 2402.9 True False 2872.843375690511 1473.2442102220527 2907.379700972438 2620.1593072656387 1773.5742578739237 3525.1764755251925 5269.974678248394 3917.165231360001 5387.045435933941 2333.522033516024 1.2311190271307904 0.6313393184474237 1.2459191124892688 1.1228346120725183 0.7600417876498893 1.51066774810506 2.2583779379652498 1.6786493442523147 2.3085470625777784 1.0 11.188293374202939 -6.964027087622537 5.220007601663978 1.8724572446496217 1.0037707043362862 0.5013102621218457 0.382594016616186 0.13796036700839645 9.435864391793 0.1294031727126808 0.11155082303795781 1.0863578636737636e-07 6.964027087622537 -0.8686865403133355 QEQTEDCPPSS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 QEQTEDCPPSSPSR 14 0 Q15008-4;C9J0E9;C9J7B7 Q15008-4 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 QEQTEDCPPS(0.041)S(0.905)PS(0.054)R 144.4 0.00033504 0.0 2832.6 2752.9 3962.2 3541.3 4545.4 2854.9 2760.1 2579.6 2658.9 3272.5 True False 2675.1754317962273 2964.038578031345 3707.2763657171804 3058.9688309167577 3974.366215608425 3248.1365607981106 2888.4501190343926 2587.106208924232 3190.7542958732843 3178.0144220238813 0.8417757368428093 0.9326699581632898 1.166538559430528 0.9625408902231127 1.2505815543396421 1.0220647641773675 0.908885151375404 0.8140637094015022 1.0040087526856754 1.0 11.633909956401736 -7.229665177114809 6.272685302767051 0.916110406007464 1.038704274215176 0.13093702798772122 0.11936123594326864 0.3436595910608754 45.03706669144527 0.047990919911376 0.03622594293950351 5.892978042333223e-08 7.229665177114809 0.12259386820771201 QERLS(ph)PEVAPPAHR ddPTM_A459_Selumetinib_30min_R1 2 QERLSPEVAPPAHR 14 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 QERLS(1)PEVAPPAHR;QERLS(1)PEVAPPAHR 123.92 0.00085647 259860000.0 6344.9 7949.9 8880.400000000001 9556.9 8662.0 7356.5 8239.0 7914.0 3839.3999999999996 6387.5 True False 6492.72382497376 7019.122012191754 7674.49045654551 7887.966820231356 7878.523629400307 7282.500289167572 7617.525596743046 7704.095011705081 6515.181381318862 7207.397844518833 0.9008416026196505 0.9738774192310944 1.0648073857032738 1.0944264477130383 1.0931162396414484 1.0104201885713655 1.056903720464954 1.0689149090838632 0.9039575061439967 1.0 12.815262768203215 -4.969817045320613 3.0277334442660044 1.0425968305600704 0.9006283074547063 0.38255569679361323 0.05376916415815331 0.2776570959691421 4.753517875159515 0.014025509253407236 0.07722986979748185 1.071970797894236e-05 4.969817045320613 -0.141968523105364 QERLS(ph)PEVAPPAHR ddPTM_A459_Selumetinib_30min_R2 2 QERLSPEVAPPAHR 14 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 QERLS(1)PEVAPPAHR;QERLS(1)PEVAPPAHR 98.077 0.005855399999999999 119931000.0 177000.0 172841.0 181824.0 202481.0 201079.0 161463.0 133614.0 154235.0 139921.0 185560.0 True False 167163.04858713987 186097.3489285905 170125.64179500303 174902.73850079204 175817.65835093227 183703.06263481933 139827.31575111832 154683.7983150212 167909.10971938985 180202.4006572199 0.9276405196461094 1.0327129286284258 0.9440808844639932 0.970590501918402 0.9756676809504427 1.0194262782561836 0.7759459099387757 0.8583892209586039 0.9317806483543231 1.0 17.459258705306333 -7.235189608575981 24.944152119337787 0.8797280108963149 0.9787912909388607 0.3223648349472297 0.06071068932848731 744.9170615895634 707867.0734187281 0.022350729699528175 0.017307777735209914 5.818491328660379e-08 7.235189608575981 0.09906328004254583 QES(ph)DEESRPQNANYPR ddPTM_A459_Selumetinib_30min_R1 2 QESDEESRPQNANYPR 16 1 O15164-2;O15164 O15164-2 TRIM24 Transcription intermediary factor 1-alpha 1 QES(1)DEESRPQNANYPR;QES(1)DEESRPQNANYPR 205.98 3.9598e-07 7123200.0 1299.19 1612.13 1633.3400000000001 1224.62 1557.58 1387.21 1593.05 1265.79 674.4300000000001 1111.58 True False 1329.4585992163256 1423.3810701410966 1411.5413992944073 1010.7631059644583 1416.697164013084 1373.2559268859034 1472.8849559280877 1232.217137334618 1144.4584515817264 1254.2621207061045 1.0599527620812532 1.1348354117078687 1.1253958610340238 0.8058627373642082 1.1295064569242785 1.0948715617057858 1.1743039446163825 0.982423942326285 0.9124555646609478 1.0 10.292623164480938 -7.979582677395536 23.941970266194595 0.9532983933708096 1.0721924055992236 0.2119597586763904 0.09793428544772004 216.2790844485036 253614.88268761663 0.055160559989692055 0.026492531048589896 1.048135239259184e-08 7.979582677395536 0.118894012228414 QES(ph)DPEDDDVK ddPTM_A459_Selumetinib_30min_R2 2 QESDPEDDDVK 11 0 Q9H307;G3V5F0;G3V579 Q9H307 PNN Pinin 1 QES(1)DPEDDDVK;QES(1)DPEDDDVK 184.51 2.475e-05 38807000.0 257098.0 191175.0 229369.0 204512.0 193216.0 182440.0 309530.0 249582.0 200760.0 168034.0 True False 242809.52240483847 205837.50777548907 214611.64825808431 176657.1127971222 168942.47870704395 207569.45397457265 323923.7583220596 250308.24229947536 240917.60970308035 163182.42181523607 1.4879637138843331 1.2613951030126846 1.3151640101351063 1.082574402512195 1.0352982682064231 1.2720086616289712 1.9850407581818066 1.5339167020262012 1.4763698627776234 1.0 17.316126131465346 -7.03148452780816 24.986418054751407 1.5554963369962846 1.2256812710696057 0.18645153541980852 0.2519149165007616 876.0106063275517 695207.596569871 0.09405052052264573 0.07292932484588316 9.300696488606585e-08 7.03148452780816 -0.329815065926679 QES(ph)DPEDDDVKKPALQSSVVATSK ddPTM_A459_Selumetinib_30min_R1 1 QESDPEDDDVKKPALQSSVVATSK 24 2 Q9H307 Q9H307 PNN Pinin 1 QES(0.987)DPEDDDVKKPALQS(0.009)S(0.004)VVATSK 66.47399999999999 0.0028805 167310000.0 2311.7 2437.7 2863.0 2701.0 2183.4 2758.2 2757.4 2214.8 1706.5 2132.9 True False 2365.5581122148246 2152.292950744015 2474.2203253332955 2229.3210540494197 1985.9118555105786 2730.455012245224 2549.407098004525 2156.056309315694 2895.805862171338 2406.6784912053563 0.9829140538959414 0.8943001562564614 1.02806433612747 0.9263061361108067 0.8251670768520303 1.1345325194964901 1.0593052239095238 0.8958638709717552 1.2032375212365853 1.0 11.232827709347596 -6.769491465432547 24.999987907142216 1.052124140805233 0.9343847682838039 0.33030336868859367 0.09030155546010268 236.16395158617783 733233.6627974442 0.03088715087183727 0.02770986943703855 1.7002333655653044e-07 6.769491465432547 -0.11773937252142919 QES(ph)DPEDDDVKKPALQSSVVATSK ddPTM_A459_Selumetinib_30min_R2 4 QESDPEDDDVKKPALQSSVVATSK 24 2 Q9H307 Q9H307 PNN Pinin 1 QES(0.989)DPEDDDVKKPALQS(0.005)S(0.005)VVAT(0.001)SK;QES(0.932)DPEDDDVKKPALQS(0.033)S(0.033)VVAT(0.001)S(0.001)K;QES(1)DPEDDDVKKPALQSSVVATSK;QES(0.999)DPEDDDVKKPALQSSVVATSK 99.753 7.1391999999999985e-06 378140000.0 280302.0 263530.0 248665.0 282747.0 224621.0 180495.0 235729.0 232988.0 151374.0 215147.0 True False 264723.93697781063 283741.90361749503 232666.16462598144 244236.37083421965 196402.1018427818 205356.54787952465 246690.86558815176 233665.95650676024 181653.02974294717 208935.14709096207 1.2670148640073484 1.3580381643207453 1.1135807826755344 1.1689578045377345 0.9400146628143714 0.9828722009615767 1.180705443879925 1.1183659607305387 0.8694230351960011 1.0 17.672695677558274 -5.552178466676174 1.561946729125823 1.032598323050075 1.319742866219969 0.5691786921249998 0.09483301423889795 0.32454954453182056 1.5172541959580372 0.030112093621390546 0.08973249521417422 2.8042810247390635e-06 5.552178466676174 0.287144543169894 QES(ph)PSQENIDR ddPTM_A459_Selumetinib_30min_R2 1 QESPSQENIDR 11 0 H3BM14;H3BM74;H7C5N1;Q9Y5A7-2;Q9Y5A7 H3BM14 NUB1 NEDD8 ultimate buster 1 1 QES(0.5)PS(0.5)QENIDR 93.228 0.023894 4549600.0 10904.0 7718.2 12878.0 14559.0 16972.0 12480.0 12642.0 17613.0 14529.0 11484.0 True False 10297.999332170468 8310.16112207546 12049.443500506248 12576.039084324142 14839.825628394898 14199.006717839651 13229.878049647756 17664.25091401088 17435.205974178396 11152.427080984646 0.923386385527594 0.7451437307529796 1.080432394940385 1.127650420218108 1.3306364184794734 1.2731763780863048 1.1862779243995463 1.5838929755594786 1.5633552990367587 1.0 13.445070094776314 -5.76313723105836 1.0029083458986068 1.3635985907044974 0.7966300706835564 0.5467132948472144 0.17052221963254013 0.4675725096334379 0.887408532085328 0.06755311330418784 0.20277962212881231 1.725292637202433e-06 5.76313723105836 -0.566968520020941 QESCLGNS(ph)PPFEK ddPTM_A459_Selumetinib_30min_R2 3 QESCLGNSPPFEK 13 0 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 QES(0.005)CLGNS(0.995)PPFEK;QESCLGNS(1)PPFEK;QESCLGNS(1)PPFEK 149.31 0.00052299 22703000.0 340620.0 282582.0 335953.0 357123.0 386407.0 302055.0 348734.0 369120.0 307653.0 308931.0 True False 321689.7040098955 304255.1307556592 314338.1497379697 308482.2313284626 337863.098137591 343660.33446771244 364950.82200331107 370194.0780888943 369192.19654304587 300011.35933086695 1.0722584129060282 1.0141453691428797 1.047754159839336 1.0282351708831583 1.126167685420802 1.1454910748519602 1.2164566795646752 1.2339335380985574 1.2305940593932077 1.0 18.194657600958152 -6.5472410948425495 1.8839421036524144 1.187026456023764 1.0379528774149942 0.4307287507548243 0.0657786317055909 0.2744296133865465 1.9726966222785505 0.023814577994759806 0.025424705929413736 2.8363440193429363e-07 6.5472410948425495 -0.1490735786087698 QESDKNGESAS(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 QESDKNGESASPER 14 1 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 QESDKNGES(0.045)AS(0.955)PER 121.95 0.008757 871420.0 246.37 306.74 273.91 329.98 422.79 433.23 373.44 371.35 154.22 268.53 True False 252.10994164743107 270.82673820044283 236.71452647993135 272.3551874917539 384.54871914963735 428.8720995413674 345.27112014173116 361.50059168520073 261.7000762168554 302.99844120370125 0.8320502925556023 0.8938222161293897 0.7812400801124643 0.8988666291806222 1.2691442161285282 1.41542675215627 1.139514509612974 1.1930773975241984 0.8637010645243498 1.0 8.243166561448282 -6.153127118381704 5.3002713382914886 1.1686855705555665 0.8423169252134473 0.5086537046989469 0.14187757809713114 0.18628134046610179 7.615229409204675 0.04391506324540154 0.05725357020198748 7.028665601040412e-07 6.153127118381704 -0.3263686453421193 QESDKNGESAS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 QESDKNGESASPER 14 1 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 QESDKNGES(0.01)AS(0.99)PER 138.81 0.0027331 1697200.0 3893.5 2299.4 3125.8 3276.8 4337.0 3736.1 4928.7 3590.9 3621.4 4000.2 True False 3677.114856915417 2475.756586263676 2924.6894311137125 2830.49418720471 3792.147286728063 4250.7138620609585 5157.8943160337685 3601.3489244945044 4345.781190370268 3884.703832232218 0.946562470581569 0.6373089669595388 0.7528732066642866 0.7286254781431457 0.9761741050279835 1.0942182584916453 1.327744543416056 0.9270588132390796 1.1186904788757364 1.0 11.923588897179956 -6.446932935732334 2.9594587038600766 1.1019011457057795 0.7557450087883688 0.6206621536973664 0.12026736409782017 0.1693048434689015 2.8972587057006303 0.04007578254385428 0.044754303010023255 3.5732801290621617e-07 6.446932935732334 -0.34615613691741065 QESDKNGESAS(ph)PERDR ddPTM_A459_Selumetinib_30min_R1 2 QESDKNGESASPERDR 16 2 Q14676-3;Q14676 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 QES(0.006)DKNGES(0.053)AS(0.941)PERDR;QESDKNGES(0.013)AS(0.987)PERDR 110.64 0.0031203000000000003 18628500.0 3403.2 5326.0 5414.6 5917.5 5071.700000000001 5456.2 5690.4 4336.7 2337.0 4496.3 True False 3482.4879385255417 4702.429444009773 4679.3270602688335 4884.119710232303 4612.96563048136 5401.315581833223 5261.168546632674 4221.676628413114 3965.71831227332 5073.443902670844 0.6864149885824566 0.9268712799868043 0.922317689923696 0.962683298353043 0.9092375354841172 1.0646250723280444 1.0370014230103155 0.832112606229995 0.7816620008719566 1.0 12.308749679738735 -4.759813571722496 5.191900224354064 0.9396047279496307 0.6714604678696252 0.45875824012191635 0.08186546986569775 0.16522650072090697 12.549889375232233 0.021918628747791012 0.1612301898332253 1.7385469693855838e-05 4.759813571722496 -0.26814426008000547 QESSSS(ph)LEMPSGVALEEGAHVLR ddPTM_A459_Selumetinib_30min_R2 1 QESSSSLEMPSGVALEEGAHVLR 23 0 P48553 P48553 TRAPPC10 Trafficking protein particle complex subunit 10 1 QES(0.099)S(0.105)S(0.24)S(0.556)LEMPSGVALEEGAHVLR 61.597 0.031945 0.0 5769.0 3970.9 6026.8 5124.5 6884.4 4666.8 6245.2 7029.0 5460.7 5194.6 True False 5448.382075136776 4275.455261544068 5639.042249483692 4426.534259744425 6019.520124683114 5309.609339007541 6535.614174629031 7049.453226286409 6552.992584706171 5044.618400808327 1.080038496918568 0.8475279836546186 1.1178332633802621 0.8774765320277024 1.1932557918986642 1.0525294317914617 1.2955616570684105 1.3974205115607625 1.2990065975369214 1.0 12.300529425731416 -6.828558839671325 1.3851934326396196 1.2752703514148716 0.9861857450997549 0.3766628345991043 0.13644067434578677 0.37231174628763597 1.487835409389944 0.06273884101297218 0.053447475564300385 1.4840248057914989e-07 6.828558839671325 -0.2890846063151167 QESTEYRR ddPTM_A459_Selumetinib_30min_R2 3 QESTEYRR 8 1 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ;; 150.36 0.0017522000000000002 34446600.0 46468.0 41509.0 40879.0 31198.9 43249.0 35098.6 71668.0 139918.0 51360.0 130069.0 False True 43885.49458614244 44692.606827528485 38248.889645689895 26949.555998895583 37815.673969034375 39933.113556631935 75000.70400744792 140325.13821532825 61633.43511830152 126313.57001015285 0.3474329367985958 0.35382268764896896 0.30280903027770906 0.21335440045538598 0.29937934590871607 0.3161427038553513 0.5937660063081068 1.1109268640261627 0.4879399348252728 1.0 16.946650112253522 -7.454233452911156 3.5209404915198412 0.85312983698882 0.3044286372089524 0.7237283839489199 0.1551990705322817 0.12004623195865989 2.8980423912305366 0.06811740183216052 0.04187404383971069 3.513715116868372e-08 7.454233452911156 -0.5487011997798675 QETVADFT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 QETVADFTPK 10 0 O75400-3;O75400;F5H578;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 QET(0.006)VADFT(0.994)PK;QET(0.061)VADFT(0.939)PK 129.17 0.0070015 93849000.0 17667.9 18400.8 7966.2 6133.700000000001 10801.8 10666.5 17136.9 18142.6 10637.3 20234.5 True False 18079.52769425112 16246.425781700154 6884.433795204368 5062.56443880893 9824.779097212686 10559.20469440711 15844.249836002666 17661.39931252976 18050.721182347013 22831.79517572074 0.7918574757308979 0.7115702316292918 0.3015283617525289 0.22173308755819804 0.4303112839616013 0.46247807555823445 0.6939554999534767 0.7735440501547086 0.7905957916766043 1.0 14.47875667710114 -7.724972733533389 1.3158260578552123 0.908433513309371 0.4724115240038748 0.5045388497514894 0.16675711580956143 0.43196184170089 1.378249336233856 0.15345968967831886 0.06105795463137371 1.8837673550203808e-08 7.724972733533389 -0.43602198930549624 QETVADFT(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 QETVADFTPK 10 0 O75400-3;O75400;F5H578;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 QET(0.098)VADFT(0.902)PK;QET(0.001)VADFT(0.999)PK;QET(0.009)VADFT(0.991)PK 120.29 0.01201 115494000.0 477360.0 273148.0 362200.0 413580.0 410620.0 402080.0 604250.0 586550.0 452140.0 303946.0 True False 450830.2422234858 294097.5732907505 338896.4463335431 357249.6905347061 359034.24461062445 457462.87028116756 632348.8222986605 588256.7633914208 542580.6338471351 295170.2892334511 1.5273564402239777 0.9963657726342091 1.1481387480211764 1.2103172425059223 1.2163630883820529 1.5498269540243554 2.14231867286119 1.9929402953092161 1.838195284681943 1.0 18.17118798671339 -6.927118485553904 3.6501172744666177 1.829960199286459 1.2034207667821546 0.37432561159063693 0.31148452410386274 0.20042434410470641 5.3381526718962675 0.1109843338167345 0.09536240544195257 1.1827188387201356e-07 6.927118485553904 -0.6265394325043043 QEVGPPLPPLLAPLIAT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 QEVGPPLPPLLAPLIATPPR 20 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 QEVGPPLPPLLAPLIAT(1)PPR;QEVGPPLPPLLAPLIAT(1)PPR 119.25 0.00059708 39989000.0 122897.0 106557.0 125508.0 164094.0 143965.0 100625.0 125218.0 143518.0 116465.0 127333.0 True False 116066.87673567062 114729.57926524253 117432.9519227783 141744.1141220608 125878.8296365703 114485.18036719659 131040.88511475976 143935.6136193161 139761.254303991 123656.56543913421 0.9386228407969219 0.9278082312719118 0.9496701732394527 1.1462724491715692 1.0179712592658894 0.9258317984219615 1.0597163575536976 1.163994916955409 1.1302372325130103 1.0 16.91597931485228 -4.89238852929054 0.46117153612311446 1.0835243265170238 0.8073157443649086 0.311217649321923 0.07394617918506176 5.784561062020954 1.030479245929186 0.05775464966418875 0.8674157883810267 1.2811838948251855e-05 4.89238852929054 -0.2762085821521152 QEYDESGPS(ph)IVHR ddPTM_A459_Selumetinib_30min_R1 2 QEYDESGPSIVHR 13 0 P60709;Q6S8J3;A5A3E0;A0A2R8YFE2;Q9BYX7;P63261;P0CG38;P0CG39 P60709;P63261;P0CG38 ACTB;POTEE;POTEF;POTEKP;ACTG1;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member I;POTE ankyrin domain family member J 1 QEYDESGPS(1)IVHR;QEYDESGPS(1)IVHR 207.08 1.148e-05 72658000.0 5986.4 9958.3 6759.9 7053.3 7678.799999999999 7046.299999999999 9160.2 8526.8 4474.3 7535.8 True False 6125.871472493325 8792.377606511925 5841.942709472772 5821.573561838868 6984.253895802248 6975.420619528506 8469.238739080669 8300.64156505014 7592.560310057556 8503.09333490802 0.7204285818367522 1.0340210627132949 0.6870373497477275 0.684641851211885 0.8213780115913308 0.8203391806711199 0.9960185553075882 0.9761908094050022 0.8929174373386655 1.0 13.053772058510624 -7.1738300866479285 4.5728933920782975 0.9641081683819394 0.7943228251976006 0.428006950726867 0.09746353092574245 0.24068139101138689 8.823150357698461 0.03951346696715842 0.030054903699042953 6.701467463145489e-08 7.1738300866479285 -0.1697853431843388 QEYDESGPS(ph)IVHR ddPTM_A459_Selumetinib_30min_R2 3 QEYDESGPSIVHR 13 0 P60709;Q6S8J3;A5A3E0;A0A2R8YFE2;Q9BYX7;P63261;P0CG38;P0CG39 P60709;P63261;P0CG38 ACTB;POTEE;POTEF;POTEKP;ACTG1;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member I;POTE ankyrin domain family member J 1 QEYDESGPS(1)IVHR;QEYDESGPS(1)IVHR;QEYDESGPS(1)IVHR 168.16 0.0001899 121213200.0 463771.0 466766.0 525596.0 461727.0 541818.0 395524.0 335897.0 362868.0 349865.0 461399.0 True False 437996.46444240917 502565.45131075504 491779.7255856557 398838.98607649794 473749.97892562236 450003.8407906103 351516.8760672784 363923.8858039687 419847.77604487084 448077.21201142704 0.9775022087738736 1.1216045758156932 1.097533443796544 0.8901121846525116 1.0572954085278066 1.004299769610096 0.7845006767679894 0.8121901227029769 0.9369987243050506 1.0 18.77338783124616 -7.125680000586175 6.202247350560787 0.8684791195009809 1.030046374094383 0.40962868589305645 0.08266699395094175 0.21974347916892545 10.183441934759882 0.03202481802076511 0.024765293853131566 7.487209743069207e-08 7.125680000586175 0.16156725459340215 QEYDESGPSIVHR ddPTM_A459_Selumetinib_30min_R1 4 QEYDESGPSIVHR 13 0 P60709;Q6S8J3;A5A3E0;A0A2R8YFE2;Q9BYX7;P63261;P0CG38;P0CG39 P60709;P63261;P0CG38 ACTB;POTEE;POTEF;POTEKP;ACTG1;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 ;;; 228.17 8.1982e-13 697244200.0 27607.2 36476.1 27607.0 31274.8 35981.2 30951.1 34564.5 27504.0 16137.6 25236.8 False True 28250.39404573998 32205.46125472118 23858.12103439619 25813.243280705217 32726.70681299683 30639.76003535029 31957.271936961402 26774.50457441705 27384.32855632947 28476.189107248967 0.9920707416059578 1.1309610683306945 0.8378270331237128 0.90648517550876 1.1492656791166567 1.0759782469470454 1.1222453895288356 0.9402418446364814 0.9616570691110647 1.0 14.797468466726468 -4.469287782086046 17.948721843059793 1.0155604938360585 0.7770597635040785 0.004049757793456954 0.09926407027359546 31323687.1644359 226046128.4656071 0.026109259753521883 272366394.66079485 3.394002969162246e-05 4.469287782086046 -0.23850073033198005 QEYDESGPSIVHR ddPTM_A459_Selumetinib_30min_R2 4 QEYDESGPSIVHR 13 0 P60709;Q6S8J3;A5A3E0;A0A2R8YFE2;Q9BYX7;P63261;P0CG38;P0CG39 P60709;P63261;P0CG38 ACTB;POTEE;POTEF;POTEKP;ACTG1;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 ;;; 239.38 1.3627999999999999e-17 668677100.0 632404.0 535816.0 824289.0 947996.0 1026390.0 674572.0 625930.0 632999.0 654769.0 829719.0 False True 597257.5173937946 576911.3642800116 771255.143158006 818877.3094156835 897445.7121569791 767488.1698450744 655036.9852567654 634840.9222913738 785741.095774439 805762.8566011393 0.7412323768721981 0.7159815813718856 0.9571738593304072 1.0162758219829882 1.1137839189343817 0.952498819668215 0.8129401596144996 0.7878756349842848 0.9751517947710374 1.0 19.61999577727699 -5.261912332451316 24.895804275065252 0.9475169464632681 0.7286069619381543 0.49918041635333876 0.0894001029716483 35.68212511149237 1878410.5690463537 0.02663188932659085 0.06148764696629254 5.471263957709327e-06 5.261912332451316 -0.2189099845251138 QEYDESGPSIVHRK ddPTM_A459_Selumetinib_30min_R1 1 QEYDESGPSIVHRK 14 1 P60709;Q6S8J3;A5A3E0;A0A2R8YFE2;Q9BYX7;P63261;P0CG38;P0CG39 P60709;P63261;P0CG38 ACTB;POTEE;POTEF;POTEKP;ACTG1;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 68.171 0.043292 10069000.0 7182.5 4113.5 14779.0 15510.0 12465.0 6207.8 8835.0 5048.5 3035.3 3343.0 False True 7349.838275287873 3631.8895076857298 12772.092975236044 12801.46965875843 11337.542950874491 6145.355168231424 8168.568836900695 4914.597380160862 5150.682410459223 3772.1066135775254 1.948470451188327 0.9628279048669806 3.3859310681366956 3.393718940148755 3.0056263282870965 1.6291573377357624 2.165519078251475 1.302878705090411 1.365465756434237 1.0 11.881154737108272 -7.586705204940514 1.2749406082808419 1.136622072811483 2.4869118682668416 0.35366380633494954 0.7192507063185803 0.5961424659550437 1.8118581531723803 0.6155188301651843 0.27102683365532626 2.5899703664373278e-08 7.586705204940514 1.3502897954553585 QFCQEGQPHVLEALS(ph)PPQTSGLSPSR ddPTM_A459_Selumetinib_30min_R1 2 QFCQEGQPHVLEALSPPQTSGLSPSR 26 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 QFCQEGQPHVLEALS(0.692)PPQT(0.134)S(0.134)GLS(0.034)PS(0.007)R;QFCQEGQPHVLEALS(1)PPQTSGLSPSR 125.61 4.9031000000000006e-09 18397000.0 1469.2399999999998 1631.7 1942.77 2239.3 1918.28 1811.35 1793.54 1892.54 1014.36 1473.0900000000001 True False 1503.4704333566233 1440.6598054432507 1678.9525048717317 1848.2482918670373 1744.7719126998422 1793.1294635742115 1658.2518338126617 1842.343691363701 1721.2948340768357 1662.175450611701 0.9045196960425133 0.8667314902966893 1.0100934316253176 1.1119453672516093 1.049691783173518 1.0787847112736009 0.9976394689275458 1.1083930343729334 1.0355674748074146 1.0 10.698856958207074 -5.384623143857916 3.9850620845975455 1.05775594814694 0.8860680970721803 0.7516073633110562 0.03813180173664511 0.0962032284107716 2.594664095189394 0.00958310160362484 0.02153402670419363 4.1245526916805426e-06 5.384623143857916 -0.1716878510747598 QFCQEGQPHVLEALS(ph)PPQTSGLSPSR ddPTM_A459_Selumetinib_30min_R2 1 QFCQEGQPHVLEALSPPQTSGLSPSR 26 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 QFCQEGQPHVLEALS(0.607)PPQT(0.186)S(0.186)GLS(0.018)PS(0.003)R 130.75 3.9121e-09 64049000.0 57537.0 52253.0 63955.0 65257.0 74823.0 50605.0 56736.0 54236.0 45731.0 57785.0 True False 54339.3238788602 56260.63708012351 59840.20492893904 56368.88402539604 65423.06581389304 57575.37940354776 59374.336420251224 54393.817780746875 54878.477830900454 56116.59690653939 0.9683289236045589 1.0025668016509273 1.0663548438014019 1.004495766542594 1.165841647932666 1.0259955624079973 1.0580530483546162 0.9693000071144415 0.9779366685812936 1.0 15.776139901427358 -7.763235760939957 24.995056974394437 0.9802137408895549 1.0438524796129305 0.22394251866416692 0.05037985604682183 71.20132995691989 990643.5690372849 0.02658413818656709 0.013800213784439476 1.724901258531117e-08 7.763235760939957 0.06363873872337555 QFCQEGQPHVLEALSPPQT(ph)SGLSPSR ddPTM_A459_Selumetinib_30min_R1 1 QFCQEGQPHVLEALSPPQTSGLSPSR 26 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 QFCQEGQPHVLEALSPPQT(0.287)S(0.287)GLS(0.213)PS(0.213)R 146.5 1.3405000000000002e-10 33819000.0 2030.3 1927.3 2151.2 2377.8 2604.9 2090.4 2448.9 2211.6 1034.0 1844.0 True False 2077.602039723909 1701.6508200225383 1859.078855695769 1962.5618668340278 2369.2872549324493 2069.37247393134 2264.1775013792994 2152.941183710758 1754.6224796279896 2080.6953620810536 0.998513322798946 0.8178279487875604 0.893489210182297 0.9432240310619657 1.1386997338056994 0.9945581230409488 1.0881830865979016 1.034721960238065 0.8432865817863241 1.0 11.022850037920207 -6.012203786115154 20.557476031518334 1.0226243755765962 0.8986690986713107 0.280912567471273 0.0824077653976537 65.62866412891674 110556.92274371648 0.023667167588098975 0.032337217446649545 9.722908839326428e-07 6.012203786115154 -0.12395527690528552 QFCQEGQPHVLEALSPPQT(ph)SGLSPSR ddPTM_A459_Selumetinib_30min_R2 1 QFCQEGQPHVLEALSPPQTSGLSPSR 26 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 QFCQEGQPHVLEALS(0.008)PPQT(0.351)S(0.351)GLS(0.231)PS(0.059)R 101.98 1.6091999999999996e-06 7188800.0 43363.0 42892.0 52606.0 49301.0 61071.0 40962.0 41275.0 45907.0 37848.0 39323.0 True False 40953.058055842586 46181.678480482595 49221.387233082125 42586.118751031296 53398.714998332835 46604.143683986185 43194.36928486092 46040.58176968703 45418.65756147732 38187.64281657606 1.0724164948475465 1.2093356665742294 1.2889349434188344 1.115180608438759 1.3983244594283815 1.2203985437864415 1.1311085497560902 1.2056408401751955 1.1893548334374413 1.0 15.220818249973602 -9.534466293296745 0.7202034086639622 0.9923169553587233 1.2140436537356616 0.33057995040683563 0.08706687018266059 6.055718027032093 3.337377792647435 0.21933200179038018 0.0312359406659738 2.921014458797593e-10 9.534466293296745 0.22172669837693826 QFCQEGQPHVLEALSPPQTSGLS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 QFCQEGQPHVLEALSPPQTSGLSPSR 26 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 QFCQEGQPHVLEALS(0.001)PPQT(0.139)S(0.139)GLS(0.36)PS(0.36)R 102.49 6.3096e-07 49317000.0 1638.9 1405.1 1882.6 1819.1 2005.7 1650.1 1907.4 1730.9 1099.4 1376.1 True False 1677.0831812557317 1240.5902387867325 1626.9532603815794 1501.4283337361342 1824.2847891350966 1633.5014921709248 1763.523282343451 1684.990909244418 1865.6015030009805 1552.7358393490986 1.0800827408986444 0.7989705701046893 1.047797841172773 0.9669567067927843 1.1748841901529306 1.0520150632033347 1.1357522880921676 1.085175511857033 1.2014931682024124 1.0 10.600596695406624 -6.243550732888393 23.26579046873215 1.111045170387303 0.9662993816754692 0.3603129524068338 0.08771518997105228 335.9214808281408 436894.86330758635 0.024309292873836028 0.03129496192741929 5.707543985792433e-07 6.243550732888393 -0.14474578871183374 QFCQEGQPHVLEALSPPQTSGLS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 QFCQEGQPHVLEALSPPQTSGLSPSR 26 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 QFCQEGQPHVLEALSPPQT(0.193)S(0.193)GLS(0.589)PS(0.025)R;QFCQEGQPHVLEALS(0.001)PPQT(0.094)S(0.094)GLS(0.588)PS(0.224)R 151.02 3.124e-11 69910300.0 70822.0 66749.0 78343.0 83547.0 92415.0 64081.0 61560.0 64588.0 60038.0 67158.0 True False 66885.99676292893 71868.43366813703 73302.49667340907 72167.7544733862 80805.0014994176 72907.57608059957 64422.66197882587 64775.94038688103 72047.27760188053 65218.974042560774 1.025560394729305 1.1019559065930251 1.1239443390442347 1.106545380893155 1.2389799546169746 1.1178890369085128 0.9877901780053264 0.9932069821369679 1.1046981136940872 1.0 15.993004125828227 -10.902009233195074 4.818343822558863 0.99990787389362 1.0903536070018711 0.12721914435222625 0.06980957255367023 7.6474116963826e-05 9.854079873703775e-06 0.07482004268102418 0.01812806103022916 1.2531145331708886e-11 10.902009233195074 0.0904457331082511 QFIAAQNLGPASGHGTPASS(ph)PSSSSLPSPMSPTPR ddPTM_A459_Selumetinib_30min_R2 1 QFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPR 35 0 Q8WX93;Q8WX93-3;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 QFIAAQNLGPASGHGT(0.001)PAS(0.183)S(0.522)PS(0.081)S(0.081)S(0.033)S(0.081)LPS(0.013)PMS(0.002)PT(0.001)PR 96.532 1.629e-11 4497800.0 1557.0 5219.6 5701.7 5241.5 10515.0 4415.8 5354.8 6513.4 6553.3 5952.2 True False 1470.46817316484 5619.926536340736 5334.85882954158 4527.598657908168 9194.011694707304 5024.036367358683 5603.8088103349055 6532.352915648582 7864.143114500877 5780.344520327132 0.2543910952009519 0.9722476777253897 0.9229309448218944 0.7832748795485176 1.5905646562027032 0.8691586374637671 0.969459310016657 1.1300975041672587 1.3604973002640013 1.0 12.496939767518649 -4.712705779660005 2.346437980104986 1.0797621491271399 4.469468498555041e-39 0.5356465951439654 0.2281680141631893 0.6148683298425144 3.478137044438679 0.059912759746539306 1.471369025954059 1.9377342711121076e-05 4.712705779660005 -1.0797621491271399 QFIAAQNLGPASGHGTPASSPSSSSLPSPMS(ph)PTPR ddPTM_A459_Selumetinib_30min_R1 1 QFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPR 35 0 Q8WX93;Q8WX93-3;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 QFIAAQNLGPASGHGTPASS(0.002)PS(0.008)S(0.008)S(0.021)S(0.021)LPS(0.012)PMS(0.746)PT(0.183)PR 112.3 5.1143e-15 36193000.0 2015.9 1770.1 1712.5 1887.1 5039.9 2237.4 4546.4 3259.9 434.67 911.88 True False 2062.8665477414293 1562.8558691028347 1479.9519060891605 1557.5534102542251 4584.041934866613 2214.8937873966597 4203.461387672361 3173.4368623524597 737.6032429592832 1028.9286804633782 2.004868351820475 1.5189156437927285 1.438342553949088 1.5137622653814846 4.4551600338345985 2.152621293828822 4.085279638409274 3.084214603604306 0.7168652764418069 1.0 10.006927270870957 QFIAAQNLGPASGHGTPASSPSSSSLPSPMS(ph)PTPR ddPTM_A459_Selumetinib_30min_R2 4 QFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPR 35 0 Q8WX93;Q8WX93-3;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 QFIAAQNLGPASGHGT(0.001)PAS(0.006)S(0.005)PS(0.083)S(0.062)S(0.061)S(0.061)LPS(0.116)PMS(0.477)PT(0.127)PR;QFIAAQNLGPASGHGTPAS(0.001)S(0.003)PS(0.016)S(0.038)S(0.038)S(0.038)LPS(0.234)PMS(0.586)PT(0.046)PR;QFIAAQNLGPASGHGTPAS(0.006)S(0.006)PS(0.024)S(0.105)S(0.105)S(0.105)LPS(0.077)PMS(0.507)PT(0.065)PR;QFIAAQNLGPASGHGTPASSPS(0.001)S(0.001)S(0.001)S(0.001)LPS(0.01)PMS(0.88)PT(0.104)PR 93.207 1.0585e-09 80902100.0 65472.0 52404.0 132431.0 189445.0 241390.0 136385.0 104984.0 123148.0 161212.0 211870.0 True False 61833.32834518202 56423.218294581966 123910.53363997069 163642.26418914652 211064.4301460196 155170.7957702373 109865.9640218495 123506.34029175126 193458.9046396341 205752.76259563013 0.3005224696141954 0.27422824161769144 0.602230230480523 0.7953344690236592 1.0258157775544845 0.7541614207882956 0.5339707843328996 0.6002657691380827 0.9402493662738449 1.0 17.650552275952528 -5.425150250934279 2.7560942016030063 0.7848250565630016 0.2796888557717501 0.6480927456284122 0.15133827534534072 0.1861982601560937 2.7087965556000535 0.04509914937433454 0.1113326796918253 3.7570739997964814e-06 5.425150250934279 -0.5051362007912514 QFLIS(ph)PPASPPVGWK ddPTM_A459_Selumetinib_30min_R1 1 QFLISPPASPPVGWK 15 0 H0YF64;V9GYW9;E9PD55;E9PDJ2;Q9UKA8-6;P53805-4;P53805-3;Q9UKA8-5;P53805-2;Q9UKA8-2;Q9UKA8;P53805 H0YF64 RCAN3;RCAN1 Calcipressin-3;Calcipressin-1 1 QFLIS(0.627)PPAS(0.373)PPVGWK 156.0 0.00016709 18244000.0 3881.9 4802.7 3957.7 4303.4 3701.4 4056.4 4462.8 4362.3 1898.2 3338.9 True False 3972.3407171374884 4240.397651285342 3420.26607808997 3551.8919748227613 3366.609023535245 4015.596298916515 4126.167402979105 4246.597633252596 3221.1067609573033 3767.4803386401463 1.0543759648580635 1.1255261527962992 0.907839131371419 0.9427765125656368 0.89359697222744 1.0658572674505118 1.095206087915093 1.1271718102145118 0.854976395741443 1.0 11.879384267508312 QFLISPPAS(ph)PPVGWK ddPTM_A459_Selumetinib_30min_R1 1 QFLISPPASPPVGWK 15 0 H0YF64;V9GYW9;E9PD55;E9PDJ2;Q9UKA8-6;P53805-4;P53805-3;Q9UKA8-5;P53805-2;Q9UKA8-2;Q9UKA8;P53805 H0YF64 RCAN3;RCAN1 Calcipressin-3;Calcipressin-1 1 QFLIS(0.055)PPAS(0.945)PPVGWK 144.08 0.00037477 19998000.0 3602.7 4602.8 3282.3 3913.1 2844.3 3418.9 4071.1 3853.0 1956.6 3372.5 True False 3686.635900366113 4063.902036216335 2836.5816883833295 3229.7505429843695 2587.0335672019505 3384.5089701128277 3764.013649338585 3750.8059236921495 3320.2072955900635 3805.3932259318603 0.9687923642801288 1.06793222012455 0.7454109260124387 0.8487297767219502 0.6798334399642604 0.8893979594668651 0.9891260707799409 0.9856552794944486 0.8725004483017691 1.0 11.893829825326499 -9.871584969000754 10.922526724855432 0.9999999665531938 0.892594738892802 0.0751643880587195 0.11126385424179995 0.0 0.0 0.11636023220030212 0.028221501646073118 1.3440487800135108e-10 9.871584969000754 -0.10740522766039173 QFLISPPAS(ph)PPVGWK ddPTM_A459_Selumetinib_30min_R2 2 QFLISPPASPPVGWK 15 0 H0YF64;V9GYW9;E9PD55;E9PDJ2;Q9UKA8-6;P53805-4;P53805-3;Q9UKA8-5;P53805-2;Q9UKA8-2;Q9UKA8;P53805 H0YF64 RCAN3;RCAN1 Calcipressin-3;Calcipressin-1 1 QFLIS(0.298)PPAS(0.702)PPVGWK;QFLISPPAS(1)PPVGWK 147.7 0.00031904 13828200.0 109216.0 104442.0 105929.0 94675.0 89843.0 97907.0 73140.0 78661.0 80793.0 146995.0 True False 103146.21194628837 112452.36556603933 99113.64346677477 81780.10167651529 78556.11913338925 111392.80053874418 76541.15492416063 78889.89048697044 96953.85754503355 142750.8724111232 0.7225609917761259 0.787752562675596 0.6943119981874927 0.5728868783441702 0.5503021999553688 0.7803300859551484 0.536186950253598 0.5526403387558094 0.679182241813598 1.0 17.123140036973126 -8.57232037687571 20.550303593374156 1.0000000013290036 0.6482659168177128 0.5725351987133123 0.09028970268395917 2672.8708892704385 1110971.6689797216 0.09316010779411338 0.024053836396671878 2.677192644507382e-09 8.57232037687571 -0.35173408451129073 QFNDPDNIT(ph)ECLQRK ddPTM_A459_Selumetinib_30min_R1 1 QFNDPDNITECLQRK 15 1 Q969Y0 Q969Y0 NXPE3 NXPE family member 3 1 QFNDPDNIT(1)ECLQRK 70.68 0.028334 10692000.0 4759.3 7455.0 6198.0 6680.2 6262.7 5719.9 5906.1 4861.5 2233.3 3871.6 True False 4870.18243001428 6582.165134264526 5356.345643177006 5513.628472884463 5696.239890769492 5662.362999253667 5460.59812197161 4732.557227622472 3789.746986221657 4368.557572577551 1.1148261981450227 1.5067136062443824 1.2261130943540794 1.262116472378615 1.303917779755522 1.296163071032332 1.249977373824498 1.083322618277903 0.8675053317394231 1.0 12.092941288322757 -7.8955494291788515 2.525183738739951 0.93587349736041 1.2909980912000367 0.6797300474057744 0.09666873090871834 0.1543556643104749 1.9141754989662048 0.06519882954729499 0.025261345293359962 1.2718929814871697e-08 7.8955494291788515 0.3551245938396267 QFS(ph)ALVPAFDPRPGR ddPTM_A459_Selumetinib_30min_R1 1 QFSALVPAFDPRPGR 15 1 A0A087X2H1;Q9ULT8;H0YJP0;H0YJD4 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 QFS(1)ALVPAFDPRPGR 70.987 0.02758 7159300.0 1678.9 1879.5 1958.4 2214.7 1403.2 1785.3 1765.3 1565.9 1029.2 1342.4 True False 1718.0151034292815 1659.4472662441547 1692.4600367211758 1827.944220067846 1276.280807755081 1767.3415029227042 1632.1419997488158 1524.3672452399512 1746.4772302061187 1514.7101160832992 1.1342203931876307 1.0955543563247028 1.1173491341679938 1.2067947527771847 0.8425907995222591 1.1667853037732745 1.0775276288305047 1.0063755625938666 1.153010870965936 1.0 10.56482600304333 -1.5228787452803376 0.1869834190595435 1.0311975839237233 1.487072625702874 0.07759412084198813 0.09685760706490544 163.05426846678768 1.8855448407308313 0.20102080992229457 21.34679226570262 0.029999999999999995 1.5228787452803376 0.4558750417791506 QFS(ph)ALVPAFDPRPGR ddPTM_A459_Selumetinib_30min_R2 1 QFSALVPAFDPRPGR 15 1 A0A087X2H1;Q9ULT8;H0YJP0;H0YJD4 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 QFS(1)ALVPAFDPRPGR 75.334 0.021378 2360800.0 9805.3 9252.1 8825.2 9022.8 7964.1 9064.3 7371.5 7571.6 4934.3 7167.1 True False 9260.360679725878 9961.706319809591 8257.396240151245 7793.87907480183 6963.578558042648 10312.825047477078 7714.289356350141 7593.632102454144 5921.297875861278 6960.16720063785 1.3304796296958543 1.4312452607311892 1.1863790052909235 1.1197833112525768 1.0004901257838297 1.481692141897393 1.1083482815819685 1.0910128856901944 0.850740751647264 1.0 12.764906248298402 -1.5228787452803383 0.15557027737958115 0.914320088389214 2.6991249753723463 0.3946660771921653 0.14814273628649172 73.06525494897355 0.7411436302729119 0.5013736642751354 29.66893705622335 0.02999999999999995 1.5228787452803383 1.7848048869831323 QFSNISFSRDS(ph)PEENVQSNK ddPTM_A459_Selumetinib_30min_R2 1 QFSNISFSRDSPEENVQSNK 20 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 QFS(0.004)NIS(0.009)FS(0.029)RDS(0.957)PEENVQSNK 65.023 0.0095411 6941400.0 7177.1 8563.5 10718.0 11983.0 15529.0 8191.0 8639.9 10441.0 8576.6 13896.0 True False 6778.225514207686 9220.292914007565 10028.415548876063 10350.894728172008 13578.108188978582 9319.235899505173 9041.672469637066 10471.381581399406 10292.159650226336 13494.786373856025 0.5022847584560068 0.6832485271401108 0.7431325899537397 0.7670291652949172 1.006174370813604 0.690580468732702 0.6700122713430907 0.7759575654851434 0.7626767378967731 1.0 13.720114518279525 -14.522871193055398 0.03566972934473218 2.1728862161344225 6.461671474821246e-09 0.39218840050329007 0.11135846394200766 1334.7607369754398 3.556110069711387 183.5826745387313 62.59605605250423 3.0000521693752982e-15 14.522871193055398 -2.172886209672751 QFSSCS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QFSSCSPR 8 0 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6;V9GXZ1;Q9Y2H9 Q6P0Q8;Q9Y2H9 MAST2;MAST1 Microtubule-associated serine/threonine-protein kinase 2;Microtubule-associated serine/threonine-protein kinase 1 1 QFSSCS(1)PR 86.189 0.036803 0.0 32118.0 26184.0 32988.0 37594.0 39961.0 28385.0 34087.0 37151.0 29555.0 32020.0 True False 30333.01013854099 28192.228605170083 30865.587994618734 32473.63234673272 34940.74192412732 32294.776096624868 35672.11304210913 37259.103259320844 35466.82583569704 31095.499402048783 0.9754791118274321 0.9066337298738668 0.9926062802704207 1.0443193700434068 1.1236591338303183 1.0385675328467974 1.1471792937263072 1.1982153036868726 1.1405774635463886 1.0 14.924418166972751 -5.881170376691039 1.2519611215182678 1.1226153593681847 0.9340803052841175 0.5871655547082133 0.05625414884298181 0.3111308657136288 0.9833366216418806 0.0203960065934909 0.04468636887296044 1.3147089617052982e-06 5.881170376691039 -0.18853505408406723 QFSTAS(ph)DHEQPGVSG ddPTM_A459_Selumetinib_30min_R1 2 QFSTASDHEQPGVSG 15 0 Q66K14;Q66K14-2;G3V133 Q66K14 TBC1D9B TBC1 domain family member 9B 1 QFS(0.085)T(0.09)AS(0.789)DHEQPGVS(0.036)G;QFS(0.011)T(0.097)AS(0.886)DHEQPGVS(0.005)G 91.592 0.014376 10725600.0 2668.0 3015.6000000000004 3111.6 3072.1000000000004 4022.7 3162.6 3669.3 2994.9 1543.6599999999999 2231.0 True False 2730.159208975711 2662.5321500855944 2689.061810795348 2535.6154054591716 3658.8474952653696 3130.7871154110476 3392.5217468296214 2915.465523193776 2619.4782755343745 2517.370581780276 1.084528129761869 1.0576639646764523 1.068202604041576 1.007247571657087 1.4534401576576161 1.2436735131769774 1.3476449480197077 1.1581391886815362 1.0405612485079125 1.0 11.29770189573501 QFSTAS(ph)DHEQPGVSG ddPTM_A459_Selumetinib_30min_R2 1 QFSTASDHEQPGVSG 15 0 Q66K14;Q66K14-2;G3V133 Q66K14 TBC1D9B TBC1 domain family member 9B 1 QFS(0.154)T(0.079)AS(0.765)DHEQPGVS(0.001)G 105.63 0.0046841 8717200.0 29055.0 24872.0 37009.0 44078.0 45440.0 25407.0 27368.0 33059.0 26948.0 34734.0 True False 27440.239416380486 26779.602423914996 34627.8812323525 38074.50036120886 39731.42096124586 28906.5836282173 28640.666228663187 33155.19621678792 32338.352990030926 33731.13917022996 0.8134987460073206 0.7939133715219979 1.0265849919149477 1.1287641419122962 1.1778855365878529 0.8569702755170908 0.8490868358795465 0.9829254816881384 0.9587091863939105 1.0 15.041793421519168 -5.2579887148195965 24.70213919110144 0.9978004168983318 0.8037060344605708 0.38947704168246844 0.0971110609993369 282.3912974106968 2021514.3801045395 0.028415710067433268 0.06907418168036886 5.520917852480829e-06 5.2579887148195965 -0.194094382437761 QFSTASDHEQPGVS(ph)G ddPTM_A459_Selumetinib_30min_R2 1 QFSTASDHEQPGVSG 15 0 Q66K14;Q66K14-2;G3V133 Q66K14 TBC1D9B TBC1 domain family member 9B 1 QFS(0.001)T(0.001)AS(0.001)DHEQPGVS(0.997)G 82.515 0.025237 10059000.0 12710.0 12592.0 15242.0 15649.0 20652.0 10747.0 14302.0 15339.0 11634.0 14306.0 True False 12003.629082161271 13557.76591033845 14261.346314234834 13517.579203969271 18057.5111287775 12227.301698447338 14967.071338875354 15383.633950491854 13961.12508111993 13892.9486085481 0.8640087443190885 0.9758738977841307 1.0265168839291656 0.9729813004312223 1.2997608814061987 0.8801084667457909 1.0773142376461655 1.1072979814397759 1.0049072716305796 1.0 13.762065205756748 -4.641088494883427 1.1610144324498943 1.056417397312617 0.7281608145139022 0.23317414988765528 0.1028307976292491 2.981944670869889 2.7489588301951584 0.030587697910410286 1.2872607675092087 2.2851331212124098e-05 4.641088494883427 -0.3282565827987147 QFTELLS(ph)DIGFAREGLR ddPTM_A459_Selumetinib_30min_R1 2 QFTELLSDIGFAREGLR 17 1 Q6P158;H7C109 Q6P158 DHX57 Putative ATP-dependent RNA helicase DHX57 1 QFT(0.066)ELLS(0.934)DIGFAREGLR;QFT(0.023)ELLS(0.977)DIGFAREGLR 92.269 0.023777 154176000.0 5913.1 6512.7 9321.1 9571.2 7972.7 7597.3 7494.700000000001 6954.2 4475.0 5882.3 True False 6050.863725110303 5750.1900563279105 8055.34581713733 7899.769593675607 7251.570692694513 7520.878059796486 6929.368744982416 6769.752025574856 7593.748158931586 6637.350503454108 0.9116384198727197 0.8663381651060141 1.2136387573543528 1.1901992503732521 1.0925399658976518 1.1331144943878715 1.043996206223604 1.0199479479126266 1.1440932876725078 1.0 12.696391746363544 -5.247288204610779 24.991918184006902 1.106870985801556 0.8889882548593105 0.6253411727427431 0.06676742129635777 516.2966028909544 911810.5051608414 0.017733982960562753 0.0464313220682577 5.658636484440473e-06 5.247288204610779 -0.21788273094224542 QFTPCQLLADHANS(ph)PNKK ddPTM_A459_Selumetinib_30min_R1 1 QFTPCQLLADHANSPNKK 18 1 A0A2R8Y4F5;H0YFD6;P40939 A0A2R8Y4F5 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 1 QFTPCQLLADHANS(1)PNKK 84.195 0.005587600000000001 15013000.0 2384.2 3246.0 3174.9 3472.5 2308.8 3309.5 2739.5 2667.9 1456.3 2579.1 True False 2439.7472211543827 2865.956810975541 2743.7660184773595 2866.093061898043 2099.969447651748 3276.209434785575 2532.8573094158974 2597.138625439472 2471.234736056327 2910.1526075614115 0.8383571414142404 0.9848132374669847 0.9428254763507137 0.9848600566345251 0.721601142907566 1.1257861275979284 0.8703520574264069 0.8924406983645327 0.8491770258492115 1.0 11.506879094290225 QFTQS(ph)PETEASADSFPDTK ddPTM_A459_Selumetinib_30min_R1 1 QFTQSPETEASADSFPDTK 19 0 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 QFT(0.068)QS(0.865)PET(0.068)EASADSFPDTK 102.69 0.00070586 4472600.0 2894.5 3186.0 3630.9 3573.3 3426.3 2767.9 3165.7 3101.1 1981.5 2565.1 True False 2961.936218283433 2812.981638868782 3137.8437231060643 2949.290234148385 3116.391769962397 2740.057439052122 2926.9087002803076 3018.8487542075563 3362.46077696602 2894.355571189863 1.0233491170767894 0.9718853021615349 1.0841251691187699 1.0189799289020798 1.0767135181947447 0.9466899873417041 1.0112471077895457 1.0430124011910928 1.161730372880109 1.0 11.499026452309609 -8.012014542476319 23.7901540952941 1.0880339290746226 1.0197008398217027 0.1736204467675997 0.05318297062541944 437.6442521922427 866577.1180903254 0.031122224524598598 0.013152031480778708 9.727146516002188e-09 8.012014542476319 -0.06833308925291992 QGAIYHGLAT(ph)LLNQPSPMMQR ddPTM_A459_Selumetinib_30min_R1 1 QGAIYHGLATLLNQPSPMMQR 21 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 QGAIY(0.004)HGLAT(0.812)LLNQPS(0.185)PMMQR 179.17 4.5077999999999996e-14 24272000.0 4303.2 4108.8 5289.7 4706.5 5314.3 3998.8 4056.5 4422.9 2910.6 3603.1 True False 4403.456187430388 3627.7397858707027 4571.387794242239 3884.598126946905 4833.622503315872 3958.5757026198994 3750.514939093113 4305.5903243960565 4939.075618186876 4065.5929821660716 1.0831030569824305 0.8923027469262088 1.1244086199220782 0.9554813145307192 1.1889095943737606 0.9736773257884868 0.9225013314281424 1.0590313253891241 1.2148475363501414 1.0 11.989250074856335 -8.006606134028655 24.957563002059572 1.1172623335602467 1.019195150490176 0.10844869054065898 0.09940478649728961 535.553506423299 2023275.2302898536 0.05475372310303543 0.024747423215379573 9.849039199785271e-09 8.006606134028655 -0.09806718307007078 QGAIYHGLATLLNQPS(ph)PMMQR ddPTM_A459_Selumetinib_30min_R1 1 QGAIYHGLATLLNQPSPMMQR 21 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 QGAIY(0.01)HGLAT(0.008)LLNQPS(0.982)PMMQR 183.1 8.4562e-15 20183000.0 3286.4 3244.1 3889.1 3804.8 3909.4 3383.7 3193.5 3706.3 2018.4 3310.6 True False 3362.966725778778 2864.279263858826 3360.9815812971415 3140.3631049415885 3555.7954602606283 3349.6630501537848 2952.611723898401 3607.996884240906 3425.0773818966495 3735.5477579748026 0.9002606695629515 0.7667628549906887 0.8997292496453775 0.8406700458419815 0.9518806051052535 0.8966992974464816 0.790409309476781 0.9658548405754964 0.916887590202709 1.0 11.867104091203364 -14.522878730789436 0.08235116607458383 1.4311590722980514 0.756490445407746 0.3393222834985329 0.05753547269415362 271.67433340674876 1.57149914033574 20.685557840211494 1.7942316425100069 3.0000001000996002e-15 14.522878730789436 -0.6746686268903054 QGDDEQS(ph)DWFYEK ddPTM_A459_Selumetinib_30min_R1 1 QGDDEQSDWFYEK 13 0 Q9NW75-2;Q9NW75 Q9NW75-2 GPATCH2 G patch domain-containing protein 2 1 QGDDEQS(1)DWFYEK 144.41 0.00067105 4251600.0 1800.1 1780.2 1530.3 1359.9 1608.9 1859.6 2045.5 2107.1 1571.6 1519.9 True False 1842.038827615133 1571.7733564074724 1322.4936653362006 1122.4189934845633 1463.3752790743652 1840.8941123817065 1891.206288158503 2051.2128631745973 2666.890414877515 1714.9939700797142 1.0740788945919812 0.9164891444687792 0.7711360438630173 0.6544740174406517 0.8532830462408835 1.073411419805832 1.1027480685955988 1.196046691102509 1.5550436103011813 1.0 10.743987788552078 -7.190958784294606 1.5144827264140264 1.2700576291870795 0.8435224206246628 0.5155075665900282 0.16535357107841017 0.32136594330714646 1.4496925547557205 0.09466102747396833 0.05994081828633782 6.442304017986095e-08 7.190958784294606 -0.4265352085624168 QGDETPS(ph)TNNGSDDEKTGLK ddPTM_A459_Selumetinib_30min_R2 1 QGDETPSTNNGSDDEKTGLK 20 1 Q9Y3P9;C9JGR5;B5MCD9;Q9Y3P9-4;Q9Y3P9-3 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 QGDET(0.02)PS(0.463)T(0.375)NNGS(0.142)DDEKT(0.001)GLK 64.488 0.0098887 4428300.0 14442.0 14263.0 14479.0 12421.0 11767.0 9933.0 14090.0 12775.0 5511.2 10173.0 True False 13639.371455906617 15356.926237226597 13547.436903543248 10729.23837257986 10288.724261685295 11301.180587203631 14745.212918805337 12812.173134984905 6613.593995794065 9879.279057371725 1.3806039263289345 1.554458189514098 1.3712981306499705 1.0860345487026113 1.041444846525319 1.1439276612771567 1.4925393678198358 1.296873290103564 0.6694409538780192 1.0 13.27019004931572 -1.522878745314449 0.18186541504376993 0.9630942510128871 3.2542472888099616 0.33131683641668475 0.20770932662083047 75.90295941051444 0.8613606348587636 0.4971584595166924 48.19080295458837 0.029999999997643665 1.522878745314449 2.2911530377970744 QGDETPSTNNGS(ph)DDEK ddPTM_A459_Selumetinib_30min_R2 1 QGDETPSTNNGSDDEK 16 0 Q9Y3P9;C9JGR5;B5MCD9;Q9Y3P9-4;Q9Y3P9-3 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 QGDET(0.002)PS(0.002)T(0.048)NNGS(0.948)DDEK 161.14 4.8933e-05 5016700.0 20955.0 14659.0 18561.0 18952.0 17348.0 20571.0 25556.0 24038.0 19721.0 15582.0 True False 19790.40498951137 15783.298163885902 17366.8054676888 16370.704905976449 15168.589146912253 23404.46852505445 26744.404638253312 24107.946600294876 23665.751050779276 15132.107173101955 1.3078419788547204 1.04303372843813 1.1476792537234421 1.081852297152386 1.0024108984553814 1.5466761011749253 1.767394608848183 1.5931652032671237 1.5639428653298386 1.0 13.885325278968697 -6.770602033030094 24.803755218565257 1.548381127630729 1.1122788747610244 0.4557446559999895 0.2020468444797081 136.2120361577175 368730.2671181231 0.06710489053685949 0.06001255282717534 1.695891123243104e-07 6.770602033030094 -0.4361022528697047 QGDETPSTNNGS(ph)DDEKTGLK ddPTM_A459_Selumetinib_30min_R1 2 QGDETPSTNNGSDDEKTGLK 20 1 Q9Y3P9;C9JGR5;B5MCD9;Q9Y3P9-4;Q9Y3P9-3 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 QGDETPS(0.003)T(0.003)NNGS(0.65)DDEKT(0.345)GLK;QGDET(0.014)PS(0.034)T(0.034)NNGS(0.762)DDEKT(0.155)GLK 89.803 0.00098013 25198000.0 3039.2 3430.0 4135.6 3847.6 2993.0 3199.5 2929.1 3239.7 2018.99 3053.9 True False 3110.0074467462437 3028.414005436261 3574.0082352247223 3175.6888883970933 2722.283678457069 3167.3159349135685 2708.155628768061 3153.7726319713083 3426.078568804755 3445.897812505057 0.9025245715238921 0.8788461440865251 1.0371776615820574 0.9215853345600139 0.7900070827921784 0.9191555023539806 0.7859071209077203 0.9152252340526073 0.9942484528623052 1.0 11.750664203991022 -11.576757435811375 5.792743894327091 1.200221806932877 0.9024098645440858 0.12965496460059 0.07360133888336821 0.07465995429451071 0.0006944174579911287 0.027956094428579627 0.0178343698255599 2.649979804488361e-12 11.576757435811375 -0.29781194238879116 QGDETPSTNNGS(ph)DDEKTGLK ddPTM_A459_Selumetinib_30min_R2 1 QGDETPSTNNGSDDEKTGLK 20 1 Q9Y3P9;C9JGR5;B5MCD9;Q9Y3P9-4;Q9Y3P9-3 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 QGDET(0.001)PS(0.109)T(0.109)NNGS(0.667)DDEKT(0.113)GLK 66.138 0.0088167 3829700.0 14311.0 13193.0 10837.0 8783.2 10501.0 6753.6 10774.0 9586.2 6661.1 9500.5 True False 13515.65191147207 14204.86067781887 10139.759218433466 7586.913008134892 9181.770499868899 7683.847096923227 11275.012348275988 9614.094254919153 7993.506126684543 9226.195879736564 1.4649214137276676 1.5396227072326651 1.0990184200081157 0.8223229928163547 0.9951848648731557 0.8328293911252428 1.2220651387902166 1.0420431541058572 0.8663924146939727 1.0 13.171520206994625 -5.353054301765867 3.9653965982963713 0.9757532944403707 1.5047065911674755 0.7745047261289617 0.11311349155619796 0.09921734445643556 2.811836973138785 0.030819664364279502 0.07072818753496635 4.43553181042022e-06 5.353054301765867 0.5289532967271048 QGDETPSTNNGSDDEKT(ph)GLK ddPTM_A459_Selumetinib_30min_R2 1 QGDETPSTNNGSDDEKTGLK 20 1 Q9Y3P9;C9JGR5;B5MCD9;Q9Y3P9-4;Q9Y3P9-3 Q9Y3P9 RABGAP1 Rab GTPase-activating protein 1 1 QGDET(0.005)PS(0.203)T(0.165)NNGS(0.052)DDEKT(0.574)GLK 68.08800000000001 0.019004 60573000.0 45361.0 40930.0 37012.0 37263.0 37151.0 27374.0 40610.0 32859.0 22363.0 27190.0 True False 42840.01721447032 44069.199389306916 34630.68821561863 32187.715117739583 32483.759245846028 31144.520023569108 42498.445467188416 32954.61424989972 26836.22487442711 26404.954051895897 1.6224234713786359 1.6689746667498069 1.311522381275726 1.2190028831134618 1.2302145719323327 1.1794953311548333 1.6094875750839261 1.2480466425024344 1.0163329510698484 1.0 14.688521010481255 -1.5228787452803376 0.35786368113444145 1.175076590041529 7.644736289977901 0.4965479170263758 0.16396745235146293 60.01427996534983 0.8393261314471631 0.14358602091499334 263.9487121830115 0.029999999999999995 1.5228787452803376 6.469659699936372 QGEVPES(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 1 QGEVPESPEAR 11 0 H7BYP4;U5Y3L1;Q9H930-3;Q9H930-1;Q9H930-2;Q9H930 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 QGEVPES(1)PEAR 122.66 0.0040868 6099800.0 42930.0 31703.0 35136.0 43238.0 41162.0 29550.0 33928.0 30111.0 32361.0 35130.0 True False 40544.122462406274 34134.51815878809 32875.388013184296 37348.90981028968 35990.861567051106 33620.24427180783 35505.71922705659 30198.61802485559 38834.10424188775 34115.70562129839 1.1884298367580777 1.0005514333397798 0.963643794389533 1.0947717225867024 1.0549645950920055 0.9854770305796858 1.040744096610167 0.8851822782174154 1.1383057607826135 1.0 15.058148435678866 -6.747493724142594 23.889848475769732 1.004690870694642 1.0536695277252461 0.08516343176510255 0.08037650711958919 380.24452682171085 651381.6377755008 0.025839482983202364 0.025692353811969548 1.7885713750217179e-07 6.747493724142594 0.04897865703060411 QGGLGPMNIPLVSDPK ddPTM_A459_Selumetinib_30min_R2 1 QGGLGPMNIPLVSDPK 16 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 153.81 0.00183 2834600.0 18641.0 13948.0 18363.0 18091.0 18472.0 15247.0 15551.0 16064.0 16694.0 14482.0 False True 17605.007845835426 15017.766750111226 17181.544572122704 15626.974591284308 16151.382218224768 17347.135851514526 16274.15231372191 16110.743580461638 20033.266469332662 14063.867031245185 1.2517899811426698 1.0678262754295669 1.221679964262396 1.1111435109964012 1.1484310952557946 1.2334541995437684 1.1571605645564065 1.1455415174694827 1.4244493655141561 1.0 13.779705715050257 -6.735559289898088 24.677561306966496 1.1990324554452134 1.155736773939545 0.01818145147431105 0.10934852949914416 798.6462462099619 761534.2967854849 0.03409854247840956 0.034086679971679905 1.8384029578943465e-07 6.735559289898088 -0.043295681505668426 QGGS(ph)PDEPDSK ddPTM_A459_Selumetinib_30min_R1 1 QGGSPDEPDSK 11 0 V9GZ50;Q9ULX6;Q9ULX6-2 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 QGGS(0.617)PDEPDS(0.383)K 159.41 0.00058593 6586800.0 3764.0 5415.6 5262.1 4969.2 4555.4 5161.6 4649.6 4879.6 4009.2 4148.9 True False 3851.6938765309496 4781.539034355866 4547.535722646295 4101.422503436644 4143.364874321191 5109.678990357829 4298.876928585567 4750.177156825382 6803.319579617542 4681.451728708283 0.8227562943586557 1.0213795445190246 0.9713943422206474 0.8761005647639815 0.8850598306744557 1.0914731767975965 0.9182785976886967 1.0146803667109607 1.4532499689994092 1.0 12.192740266828721 -8.026425907314039 19.136448493164863 1.229074530886852 0.9477744933098228 0.4499476793097591 0.1244686784558523 33.08098409749745 23952.952942256685 0.07653927463763933 0.029390495553294364 9.40966349638646e-09 8.026425907314039 -0.28130003757702926 QGGSPDEPDS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 QGGSPDEPDSK 11 0 V9GZ50;Q9ULX6;Q9ULX6-2 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 QGGS(0.054)PDEPDS(0.946)K 109.16 0.0095568 4023600.0 2480.1 2988.5 3709.4 2961.7 2641.0 3261.7 2694.9 2708.2 2377.3 2994.9 True False 2537.881504565465 2638.605030684041 3205.6838542756986 2444.4946929945086 2402.122016306422 3228.8902593866464 2491.6215233235616 2636.3697385266223 4034.1044688777797 3379.3245877963923 0.7510025860582928 0.7808084018364855 0.9486167341995632 0.7233678297202364 0.7108290292625635 0.9554839067685292 0.7373134656319923 0.7801469406186163 1.193760576727659 1.0 11.722519214244597 -8.252218246437506 24.850192241087946 1.0968802904859352 0.8006375255706055 0.6236531496184831 0.09271981436544396 333.61335862136264 899066.92729107 0.06290725840205212 0.023034169861559428 5.594763766194819e-09 8.252218246437506 -0.29624276491532964 QGGSPDEPDS(ph)K ddPTM_A459_Selumetinib_30min_R2 4 QGGSPDEPDSK 11 0 V9GZ50;Q9ULX6;Q9ULX6-2 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 QGGS(0.008)PDEPDS(0.992)K;QGGSPDEPDS(1)K;QGGS(0.087)PDEPDS(0.913)K;QGGS(0.003)PDEPDS(0.997)K 150.14 0.00061878 14819300.0 102176.0 70638.0 80413.0 98140.0 78825.0 75934.0 128603.0 217878.0 89558.0 147757.0 True False 96497.46696293553 76055.70746303095 75239.31512705449 84773.1626990569 68922.29879555904 86393.21923977861 134583.29432200996 218511.98890835533 107472.10245959589 143490.87149120957 0.6724989956510724 0.5300386475643519 0.5243491404375765 0.5907913292188083 0.4803253202053435 0.6020816400510269 0.937922342539084 1.5228285021722907 0.748982157141472 1.0 17.130599433823747 -7.34570304183068 3.6255618960395624 1.119648676837115 0.5578578154245192 0.6250806951110129 0.1856342510476783 0.13992069744611949 3.4996233607859715 0.07765604065274614 0.05073329371580436 4.51125065547188e-08 7.34570304183068 -0.5617908614125958 QGGSQPSSFS(ph)PGQSQVTPQDQEK ddPTM_A459_Selumetinib_30min_R1 2 QGGSQPSSFSPGQSQVTPQDQEK 23 0 Q9H0L4 Q9H0L4 CSTF2T Cleavage stimulation factor subunit 2 tau variant 1 QGGS(0.002)QPS(0.018)S(0.074)FS(0.905)PGQS(0.001)QVTPQDQEK;QGGS(0.005)QPS(0.127)S(0.105)FS(0.665)PGQS(0.097)QVT(0.001)PQDQEK 127.15 6.1678e-06 5491000.0 2112.16 2247.9900000000002 2678.15 2547.85 2609.1800000000003 2179.2 2438.08 2589.59 1464.13 2156.76 True False 2161.3692184520764 1984.7942857378011 2314.4719400249273 2102.9158265678693 2373.180129688145 2157.279226555288 2254.1736626905313 2520.9056610261996 2484.5216741757536 2433.6011546214377 0.8881361739772397 0.8155791190222987 0.9510481763331339 0.8641168757560815 0.9751721744466827 0.8864555403660082 0.9262707894470827 1.03587461578861 1.020923937949987 1.0 11.248877027323585 -7.6627684125291795 4.250240546289621 1.0213498036941522 0.8982331317176543 0.6262514207571677 0.04215711044344902 0.14040839925631127 4.54981153632041 0.021408918747668735 0.011619937412521063 2.1738600804235117e-08 7.6627684125291795 -0.1231166719764979 QGGSQPSSFS(ph)PGQSQVTPQDQEK ddPTM_A459_Selumetinib_30min_R2 2 QGGSQPSSFSPGQSQVTPQDQEK 23 0 Q9H0L4 Q9H0L4 CSTF2T Cleavage stimulation factor subunit 2 tau variant 1 QGGS(0.003)QPS(0.04)S(0.109)FS(0.847)PGQSQVTPQDQEK;QGGSQPS(0.002)S(0.008)FS(0.989)PGQSQVTPQDQEK 203.3 2.3412e-23 14371900.0 102891.0 87699.0 104982.0 119740.0 109833.0 85890.0 95903.0 106166.0 80448.0 98061.0 True False 97172.73012530725 94425.23130326958 98227.5724157591 103431.20543697891 96034.79662052185 97720.56786820892 100362.67952818943 106474.92548327243 96539.84790492844 95229.72413692386 1.0204033562629005 0.9915520827037412 1.0314801739268389 1.086123123577075 1.008454004155682 1.0261561582148833 1.0539007693006153 1.118084993401639 1.0137575088017776 1.0 16.539124333037556 -5.515925543314407 24.26986846249654 1.0478318797479558 1.0073623103934668 0.14663041864379145 0.03511123523231717 344.31174793010143 1201803.349732917 0.009427189149846556 0.01721861876816755 3.048417574240092e-06 5.515925543314407 -0.04046956935448898 QGGSQPSSFSPGQS(ph)QVTPQDQEK ddPTM_A459_Selumetinib_30min_R1 1 QGGSQPSSFSPGQSQVTPQDQEK 23 0 Q9H0L4 Q9H0L4 CSTF2T Cleavage stimulation factor subunit 2 tau variant 1 QGGSQPS(0.003)S(0.009)FS(0.061)PGQS(0.926)QVT(0.001)PQDQEK 95.523 5.1205e-05 4523600.0 1788.2 1716.5 1777.7 1823.0 1902.1 1812.1 1921.0 1759.7 1144.4 1716.6 True False 1829.861580768503 1515.5313820207987 1536.2981042071247 1504.6472719482015 1730.055390843031 1793.8719192551569 1776.097423394027 1713.0270396888332 1941.9632163310173 1936.9423310999643 0.9447166037872425 0.7824349531150719 0.7931563472696066 0.7768157305404813 0.893188900394652 0.9261359465650381 0.9169593719320515 0.8843975435840815 1.0025921707375778 1.0 10.919565285647845 -6.494246610939915 3.6371941618914354 0.9360384203152694 0.819327335747648 0.5055659750082542 0.056060457832132 0.2036207863016498 5.691822471023081 0.018497758119824664 0.020048697108598842 3.2044491847840286e-07 6.494246610939915 -0.11671108456762136 QGIAVMTPTVPGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 QGIAVMTPTVPGSPK 15 0 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;E7EX50;H0Y7S5;Q9UPX8-2 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 QGIAVMT(0.001)PT(0.025)VPGS(0.973)PK;QGIAVMTPTVPGS(1)PK 142.4 0.00038157 68927000.0 15396.1 14795.9 16821.0 15505.4 14668.599999999999 13425.1 13514.7 15400.4 11053.5 15470.599999999999 True False 15754.799174404405 13063.589149572705 14536.800591139143 12797.672962405735 13341.827719951674 13290.055683015507 12495.2752982526 14991.931364450707 18756.982184301723 17456.40220640516 0.9025226955771907 0.7483551876903575 0.8327489490248599 0.7331220265828872 0.7642942435787969 0.761328452786169 0.7157990031684646 0.858821376088013 1.0745044690491463 1.0 14.091468627300996 -8.106078994405475 3.9410100902576626 1.0339811625090392 0.7777026028950633 0.7781656471339349 0.05412714315312371 0.1008518238447954 2.664876658524052 0.03933933455380203 0.013660778474793028 7.832871566572067e-09 8.106078994405475 -0.25627855961397583 QGIAVMTPTVPGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QGIAVMTPTVPGSPK 15 0 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;E7EX50;H0Y7S5;Q9UPX8-2 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 QGIAVMT(0.002)PT(0.008)VPGS(0.99)PK;QGIAVMT(0.001)PTVPGS(0.998)PK 144.3 0.00037388 37692000.0 167764.0 140162.0 129562.0 134787.0 122594.0 112834.0 182143.0 129814.0 96097.0 119275.0 True False 158440.34849250238 150911.97470813678 121226.12197643954 116428.77807945618 107192.64571573447 128375.85929492959 190613.01040950743 130191.73724813535 115319.08517452129 115831.2208363329 1.367855292800335 1.3028609525006412 1.0465755355175745 1.005158861650674 0.9254210129339433 1.1083010121797991 1.6456099576023604 1.1239779422863336 0.9955786042993084 1.0 16.821664640328166 -2.891918532526607 0.015649952563980763 2.3614303897018002e-06 2.4925040469754993 0.06985665378819517 0.20397022463531178 17668.308535166198 27.229340514998153 1804.3177635783263 2595.548481326669 0.0012825711522141624 2.891918532526607 2.4925016855451094 QGLAETAS(ph)PVAVSLR ddPTM_A459_Selumetinib_30min_R1 1 QGLAETASPVAVSLR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 QGLAET(0.06)AS(0.933)PVAVS(0.006)LR 173.09 3.4659e-05 44390000.0 2491.0 2804.6 2432.2 2284.2 2454.1 2003.6 2943.4 2778.7 1295.1 2751.9 True False 2549.035453357757 2476.2361281768344 2101.920599118282 1885.307349744423 2232.127088306546 1983.445603123245 2721.376968255066 2704.9998495103487 2197.6901096385022 3105.1331707759473 0.820910187475397 0.7974653555866795 0.6769180204252011 0.6071582911444987 0.7188506790350494 0.6387634584534093 0.8764123206912302 0.8711381125191456 0.7077603403042831 1.0 11.600439427728821 -7.273080730367618 24.607362662331557 0.8530892138476839 0.7082086504327622 0.4119580841030557 0.08964795661448148 690.1002985072619 1458720.1541684868 0.03816079220065052 0.02597546851925642 5.3323576385602126e-08 7.273080730367618 -0.14488056341492173 QGLAETAS(ph)PVAVSLR ddPTM_A459_Selumetinib_30min_R2 3 QGLAETASPVAVSLR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 QGLAET(0.136)AS(0.645)PVAVS(0.219)LR;QGLAET(0.01)AS(0.854)PVAVS(0.136)LR;QGLAET(0.004)AS(0.861)PVAVS(0.135)LR 187.04 2.0187e-05 80363000.0 267451.0 202989.0 235443.0 280699.0 287160.0 231059.0 265005.0 284005.0 271581.0 224407.0 True False 252587.14411118143 218557.60358749164 220294.85371095623 242467.3119672168 251084.3935570281 262885.27990523353 277328.2575974457 284831.40753044153 325904.7886071534 217927.78683059238 1.1590405601077927 1.0028900250218613 1.0108617029282452 1.11260392946449 1.1521449247415623 1.2062953684267401 1.2725695131893788 1.306999037033571 1.4954714740461146 1.0 17.733490633106733 -6.70737513542147 1.2903347648640924 1.2963230568072652 1.0567545753874155 0.3447511030331125 0.12071395049451061 0.42608628545939237 1.4907222852098978 0.05514190126721838 0.052263586314454075 1.9616650953208874e-07 6.70737513542147 -0.23956848141984977 QGLAETASPVAVS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 QGLAETASPVAVSLR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 QGLAET(0.008)AS(0.173)PVAVS(0.819)LR 123.63 0.0014202 39828000.0 3967.7 4125.5 3598.1 3347.3 3713.7 3220.9 4595.1 4070.7 1986.8 4186.5 True False 4060.139690199748 3642.484542107082 3109.497782948561 2762.7568916029695 3377.7964907069877 3188.500670343213 4248.487907463764 3962.731812502887 3371.4544898693334 4723.878054963299 0.8594929087836694 0.7710792911514692 0.6582510697289199 0.5848493249524482 0.7150473512240634 0.6749752286668597 0.8993644327884267 0.8388725886645848 0.713704810039921 1.0 12.205756007278092 -7.2567337867255315 24.888365923523505 0.8495581749280734 0.7054687501339224 0.37990213010535523 0.09461082158905308 449.01119087099715 2374874.3338172 0.03829983732550912 0.028673930531731433 5.5368940503586265e-08 7.2567337867255315 -0.144089424794151 QGLAETASPVAVS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 QGLAETASPVAVSLR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 QGLAET(0.257)AS(0.209)PVAVS(0.534)LR 167.18 7.4576e-05 33039000.0 102340.0 81619.0 109200.0 104250.0 118810.0 94242.0 115350.0 112690.0 108740.0 91511.0 True False 96652.35249947947 87878.91485355093 102174.19088797021 90050.97015871933 103884.02562512369 107222.9800563016 120714.0035616887 113017.90924316633 130491.03844945712 88868.83965586769 1.0875842744628192 0.9888608334918054 1.14971897105471 1.0133019684675673 1.1689589514997634 1.206530663295569 1.3583389186708976 1.2717383244882299 1.4683553757961243 1.0 16.4393900308389 -6.6993161723176735 1.8616210406882994 1.295425920778092 1.060947566206941 0.38101530527725824 0.11922015656771127 0.31030226538403444 2.2164540457848885 0.04487080618547898 0.04296458258092874 1.9984064727012623e-07 6.6993161723176735 -0.23447835457115107 QGLSVS(ph)PFPK ddPTM_A459_Selumetinib_30min_R2 2 QGLSVSPFPK 10 0 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 QGLS(0.021)VS(0.979)PFPK;QGLS(0.005)VS(0.995)PFPK 102.33 0.015403 9871300.0 89115.0 69846.0 77424.0 84642.0 81607.0 66583.0 76474.0 68102.0 53322.0 68789.0 True False 84162.34505560996 75202.96360971242 72442.62413287739 73113.61358440599 71354.79908416349 75754.20386970491 80030.19253035617 68300.16554510695 63987.88994116183 66802.88283471383 1.2598609743212361 1.1257442855539987 1.0844236215391725 1.0944679403328506 1.0681395181808573 1.1339960291405204 1.1980050730500633 1.0224134445529507 0.9578612063716327 1.0 16.02762274215302 -1.522878745284629 0.12888518450374514 0.9577301675311429 1.7269303884507479 0.4693889456121024 0.06274108192696666 92.4774980067708 0.8110978040811372 0.38202074275323933 12.902168871752986 0.029999999999703552 1.522878745284629 0.7692002209196049 QGNFFAS(ph)PMLK ddPTM_A459_Selumetinib_30min_R1 1 QGNFFASPMLK 11 0 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 QGNFFAS(1)PMLK 88.552 0.030484 18953000.0 3205.5 3414.6 4039.3 3650.3 3723.1 2946.8 3256.2 3372.1 1892.3 2711.0 True False 3280.181913182774 3014.817044595525 3490.7852462866863 3012.8436296174004 3386.346262366691 2917.1578674803236 3010.5822124183396 3282.6609538754956 3211.094891876255 3058.9832573762114 1.072311169168115 0.985561799766577 1.1411586637060724 0.9849166785573105 1.1070169325710104 0.953636428197539 0.9841774076921929 1.0731215824604217 1.0497262069458055 1.0 11.57883649532858 -6.753434401005552 24.999958561290203 1.0149552391476533 1.0546962547807892 0.14908894617711066 0.05449360850615555 420.0296181914348 1311771.5059641402 0.017859680507039188 0.017556184769331108 1.7642722328497903e-07 6.753434401005552 0.03974101563313592 QGNFFAS(ph)PMLK ddPTM_A459_Selumetinib_30min_R2 1 QGNFFASPMLK 11 0 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 QGNFFAS(1)PMLK 107.93 0.010265 8050000.0 56855.0 55175.0 61421.0 57327.0 72743.0 60801.0 67543.0 68333.0 54510.0 58184.0 True False 53695.22670859793 59406.74508441264 57469.23973012845 49518.963705409056 63604.37400932891 69175.78585347503 70683.8833339154 68531.83771686295 65413.52313665525 56504.07673981284 0.950289427006321 1.0513709543112415 1.0170812983063142 0.876378600670382 1.1256599112699632 1.2242618558659448 1.2509519208569149 1.2128653660236757 1.1576779395559047 1.0 15.786067340530948 -6.460780709640159 5.958740046964808 1.1865634495461133 0.9831097456762082 0.5838649914227727 0.0776330332971455 0.1479650316498177 10.626460859267416 0.023823780951819362 0.02674492217191874 3.4611409873440383e-07 6.460780709640159 -0.20345370386990502 QGPVS(ph)PGPAPPPSFIMSYK ddPTM_A459_Selumetinib_30min_R1 2 QGPVSPGPAPPPSFIMSYK 19 0 P29375 P29375 KDM5A Lysine-specific demethylase 5A 1 QGPVS(1)PGPAPPPSFIMSYK;QGPVS(0.963)PGPAPPPS(0.035)FIMS(0.001)YK 95.365 0.0017327999999999998 9950300.0 1475.49 1683.6 1825.7 2020.92 1994.35 1859.28 1869.65 1507.4 850.4300000000001 1549.77 True False 1509.8660461962413 1486.4833293155946 1577.779967852253 1668.0042593667367 1813.961394631091 1840.5773312911688 1728.6207952361483 1467.418855274732 1443.117597050321 1748.6980755381524 0.863422947229806 0.8500514469075157 0.9022597954004724 0.9538549179528418 1.0373210904763273 1.0525415204821684 0.9885187268271995 0.8391493510525777 0.8252525791830642 1.0 10.772065504439093 -5.570624929406645 2.9385459537303285 0.958665302326916 0.8579810902176144 0.24746982498476422 0.07059861538982244 0.41625984170321384 7.260272938411252 0.022884586797006265 0.04710207182925564 2.687664596671613e-06 5.570624929406645 -0.10068421210930167 QGPVS(ph)PGPAPPPSFIMSYK ddPTM_A459_Selumetinib_30min_R2 2 QGPVSPGPAPPPSFIMSYK 19 0 P29375 P29375 KDM5A Lysine-specific demethylase 5A 1 QGPVS(1)PGPAPPPSFIMSYK;QGPVS(1)PGPAPPPSFIMSYK 181.6 3.7473e-13 7595100.0 88670.0 80987.0 101326.0 105294.0 102325.0 78792.0 83720.0 86657.0 75469.0 93060.0 True False 83742.07637413371 87198.44248575144 94806.79547540715 90952.77555771866 89470.01870289359 89644.88279743759 87613.14588803274 86909.1575231614 90564.90878004485 90373.11600108241 0.9266259710811645 0.9648714832927422 1.0490597167665618 1.006414070713566 0.9900070138316576 0.9919419265831655 0.9694602749669867 0.9616704764514313 1.0021222326666277 1.0 16.46360604621374 QGPVSQSATQQPVTADKQQGHEPVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 QGPVSQSATQQPVTADKQQGHEPVSPR 27 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 QGPVSQSATQQPVTADKQQGHEPVS(1)PR 141.0 1.115e-12 12867000.0 931.8 856.95 2035.1 1896.2 1703.1 1171.7 1359.4 1342.6 762.71 895.0 True False 953.5091270328209 756.6178956147535 1758.7445980041186 1565.0642660823808 1549.054905706727 1159.9137618184795 1256.8593635407806 1306.989886620576 1294.2631638656328 1009.8819680382545 0.9441787824819363 0.7492141849849255 1.7415348067067349 1.5497496891865445 1.5338969847296535 1.1485636921230202 1.2445606549271218 1.2942006372878092 1.281598448955181 1.0 9.979970969642487 -5.240113311695675 24.924148762393102 1.362617386266707 0.8466963799321422 0.4839316324026286 0.20722741418548274 662.1280466244874 773837.9037803977 0.05460500205552482 0.14416972517498686 5.752898189904517e-06 5.240113311695675 -0.5159210063345648 QGPVSQSATQQPVTADKQQGHEPVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 QGPVSQSATQQPVTADKQQGHEPVSPR 27 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 QGPVSQSATQQPVTADKQQGHEPVS(1)PR;QGPVSQSATQQPVTADKQQGHEPVS(1)PR;QGPVSQSATQQPVT(0.015)ADKQQGHEPVS(0.985)PR 128.59 3.6086e-12 19828400.0 31743.0 38289.0 33397.5 43226.0 34681.09 22055.14 21220.2 25320.129999999997 17931.5 38540.6 True False 29978.85113729705 41225.64318146034 31248.74121044861 37338.54423099082 30324.141421321605 25093.03533837293 22206.98134702859 25393.807386326815 21518.301047971625 37427.83273749536 0.8009774797156265 1.1014702205869462 0.8349065100727431 0.997614382132923 0.8102029747221445 0.6704378400525078 0.593328005465343 0.6784738930632014 0.574927786999927 1.0 15.191823890801166 -6.547296581122267 3.296337120932709 0.6769834518362052 0.9379421890848244 0.38390672338020826 0.13499562070757984 0.2162409293178383 4.903743951898992 0.04303335885396059 0.04500152416358788 2.8359816658451323e-07 6.547296581122267 0.2609587372486192 QGQDVAPPPNPVPQRT(ph)SPTGPK ddPTM_A459_Selumetinib_30min_R1 2 QGQDVAPPPNPVPQRTSPTGPK 22 1 Q9UPY8-2 Q9UPY8-2 MAPRE3 Microtubule-associated protein RP/EB family member 3 1 QGQDVAPPPNPVPQRT(0.479)S(0.479)PT(0.043)GPK;QGQDVAPPPNPVPQRT(0.474)S(0.474)PT(0.052)GPK 123.68 4.4696e-05 39606000.0 8127.0 5337.6 12401.599999999999 12946.1 9819.3 8089.4 7419.3 7217.7 5799.799999999999 5865.5 True False 8316.343287610793 4712.67131061708 10717.53083711261 10685.306663394742 8931.146048738223 8008.027980587527 6859.656227687301 7026.263149606229 9841.836999367913 6618.394059808246 1.2565500350173682 0.7120566209914705 1.6193552001077325 1.6144863190126104 1.3494430775850454 1.2099654248782434 1.0364532794056758 1.061626594928045 1.4870430667062848 1.0 12.692265477069009 -6.946678483120866 5.427934442321201 1.1475372927004885 1.3098966264226861 0.07863987629763058 0.26594357428422843 0.6122907786993197 38.778486394228494 0.10253119479159274 0.08936103164977396 1.1306326348359971e-07 6.946678483120866 0.16235933372219757 QGQDVAPPPNPVPQRT(ph)SPTGPK ddPTM_A459_Selumetinib_30min_R2 2 QGQDVAPPPNPVPQRTSPTGPK 22 1 Q9UPY8-2 Q9UPY8-2 MAPRE3 Microtubule-associated protein RP/EB family member 3 1 QGQDVAPPPNPVPQRT(0.492)S(0.492)PT(0.017)GPK;QGQDVAPPPNPVPQRT(0.466)S(0.466)PT(0.067)GPK 113.29 5.3068e-05 70024000.0 247810.0 294810.0 268510.0 292620.0 276380.0 153571.0 109938.0 126726.0 78985.0 270810.0 True False 234037.71226202883 317420.9790364422 251234.358931583 252764.6512023446 241658.67353145094 174724.01127126225 115050.33483801411 127094.75167938118 94784.2070252928 262991.01165111916 0.8899076466252032 1.206965124182758 0.9552963706032189 0.9611151712578652 0.9188856760322766 0.6643725584927941 0.43746869566264324 0.4832665226140261 0.36040854183652643 1.0 18.004653967232144 -6.78257482073391 2.2504515161784044 0.52608460610808 1.012306621917743 0.5525509604017256 0.17946431330586848 0.19966049971942085 2.0763605040621247 0.06684768529149566 0.06082677562220038 1.6497767514711922e-07 6.78257482073391 0.48622201580966296 QGQSQAASSSSVT(ph)SPIK ddPTM_A459_Selumetinib_30min_R1 1 QGQSQAASSSSVTSPIK 17 0 O60583-2;O60583 O60583-2 CCNT2 Cyclin-T2 1 QGQSQAAS(0.001)SS(0.003)S(0.008)VT(0.886)S(0.102)PIK 95.554 0.021924000000000003 0.0 1693.4 1904.7 2328.6 2673.9 1780.2 1791.1 1590.6 1792.5 1243.3 1505.8 True False 1732.852925217193 1681.6968385289933 2012.388910084216 2206.953560319418 1619.181224319837 1773.0831601886828 1470.6197614005923 1744.9570771394178 2109.7892929608124 1699.0840977340836 1.0198747239928523 0.9897666871061426 1.1843962949026237 1.2989077840600325 0.9529729731913765 1.0435523247809129 0.865536769699526 1.0269986514890646 1.241721522657089 1.0 10.730541546472777 QGS(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R1 4 QGSFSEDVISHK 12 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 QGS(0.92)FS(0.08)EDVISHK;QGS(0.957)FS(0.042)EDVIS(0.001)HK;QGS(0.972)FS(0.028)EDVISHK;QGS(0.999)FS(0.001)EDVISHK 209.23 4.8318e-06 101622000.0 20911.0 21610.8 24345.899999999998 24291.0 21748.7 20719.9 21586.899999999998 20177.5 11655.5 18270.4 True False 21398.185614277012 19080.597489411648 21039.86050245611 20049.032848542927 19781.533925044863 20511.476618163964 19958.582753287104 19642.327154243012 19778.53221596136 20615.583808766616 1.0379616610797895 0.9255424278257778 1.0205803870327006 0.9725183159749875 0.9595427472993959 0.994950073130678 0.9681308537476331 0.9527902453041502 0.9593971434149099 1.0 14.331447696758277 -4.729278003168011 24.774694312121383 0.9727771667333186 1.0379621640932395 0.3707445882096312 0.02554270386383509 4565.683696612197 3516832.5950270216 0.0060402692071194666 0.9707844052606757 1.8651853550645858e-05 4.729278003168011 0.0651849973599209 QGS(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R2 5 QGSFSEDVISHK 12 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 QGS(0.9)FS(0.1)EDVISHK;QGS(0.911)FS(0.089)EDVISHK;QGS(0.999)FS(0.001)EDVISHK;QGS(0.958)FS(0.041)EDVISHK;QGS(0.951)FS(0.049)EDVISHK 135.69 0.00097199 152565200.0 363401.0 311780.0 351282.0 343733.0 326437.0 235600.0 304510.0 297245.0 238491.0 294307.0 True False 343204.627229464 335692.52346929134 328680.89856692293 296915.97242750175 285427.06567619275 268051.76143613964 318670.3183751177 298109.9337384413 286195.86399530387 285809.5922085819 1.2008156359531683 1.1745320402833268 1.1499995364992992 1.0388593683406344 0.9986616035891825 0.9378683177313282 1.114974189328657 1.0430368394384844 1.0013515004298388 1.0 18.124694810742923 -5.718268832023878 2.8199019447325098 1.0186127046244988 1.1846748042744668 0.7458128856542119 0.042230162969152246 0.13864250670895784 2.2395597996345042 0.012952725386073295 0.02380129826333788 1.9130713507890603e-06 5.718268832023878 0.166062099649968 QGS(ph)FTIEKPSPNIPIELIPHINK ddPTM_A459_Selumetinib_30min_R1 4 QGSFTIEKPSPNIPIELIPHINK 23 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 QGS(0.491)FT(0.491)IEKPS(0.018)PNIPIELIPHINK;QGS(0.916)FT(0.084)IEKPSPNIPIELIPHINK;QGS(0.497)FT(0.497)IEKPS(0.006)PNIPIELIPHINK;QGS(0.484)FT(0.484)IEKPS(0.032)PNIPIELIPHINK 111.55 7.9287e-06 182857700.0 18273.3 19971.399999999998 22691.3 23817.3 17941.7 18694.7 20116.5 19887.6 11776.199999999999 17297.5 True False 18699.032336347773 17633.139203548035 19609.94609438889 19658.05566109265 16318.87640286442 18506.6482914295 18599.096209112937 19360.11624397093 19983.351300382157 19517.80261691811 0.9580500788618169 0.9034387502342891 1.0047209964809722 1.0071859033994415 0.8361021331734932 0.9481932292617747 0.9529298238210056 0.9919208951928585 1.023852515193514 1.0 14.252503017894817 -7.813474940410751 2.66684772011786 1.011604406694022 0.9425183131470901 0.27380521268273106 0.04635991828825567 0.39401733236908554 5.572754355892982 0.031736720440980325 0.0135177968268639 1.536473448113707e-08 7.813474940410751 -0.06908609354693185 QGS(ph)FTIEKPSPNIPIELIPHINK ddPTM_A459_Selumetinib_30min_R2 1 QGSFTIEKPSPNIPIELIPHINK 23 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 QGS(0.518)FT(0.141)IEKPS(0.341)PNIPIELIPHINK 52.739 0.016124 100810000.0 243470.0 213740.0 252360.0 238200.0 274520.0 196870.0 242660.0 208260.0 168960.0 251920.0 True False 229938.91208763234 230133.17071757754 236123.43234879337 205756.74908208035 240032.34336006155 223987.05549207484 253944.17082166768 208866.00212070107 202756.72113684207 244646.415033233 0.9398826140836652 0.9406766524100344 0.9651620372884603 0.8410372539247312 0.9811398353311465 0.9155542110095839 1.0380048724080901 0.8537464245790338 0.8287745443124495 1.0 17.900338616591903 QGS(ph)GVILR ddPTM_A459_Selumetinib_30min_R1 1 QGSGVILR 8 0 P46108-2;I3L297;P46108 P46108-2;P46108 CRK Adapter molecule crk 1 QGS(1)GVILR 84.198 0.040524 0.0 1657.8 1940.1 2261.2 2307.8 2042.6 1953.9 1998.6 1880.5 1147.0 1463.0 True False 1696.4235144827333 1712.9521900719787 1954.1414598825183 1904.7860527712892 1857.8471906503205 1934.2455399992564 1847.8439929179087 1830.623031275131 1946.3752264345298 1650.790300826779 1.027643252830538 1.0376558362464734 1.1837611711819542 1.1538631235095695 1.1254289474076988 1.1717088106408864 1.119369305715231 1.1089373558581517 1.1790566163732066 1.0 10.688941151629356 -5.227525598234012 14.49466033268435 1.135915937947851 1.0326298551263535 0.37125135709625423 0.050386897122357124 4.0200237457389125 1715.2136225257502 0.011803869289150701 0.031144401274468644 5.922081798465049e-06 5.227525598234012 -0.10328608282149743 QGS(ph)PDQVS(ph)PVSEMTSTSLYQDK ddPTM_A459_Selumetinib_30min_R1 2 QGSPDQVSPVSEMTSTSLYQDK 22 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 QGS(1)PDQVS(1)PVSEMTSTSLYQDK;QGS(1)PDQVS(1)PVSEMTSTSLYQDK 142.22 2.1537e-05 17652100.0 7573.799999999999 9004.2 7572.299999999999 7647.299999999999 7233.1 8056.5 8166.0 8213.0 4754.8 7839.200000000001 True False 7750.254803950616 7949.984078060982 6544.023251666546 6311.842612599825 6578.867382107524 7975.458924716721 7550.032045515678 7995.164560416203 8068.548323148129 8845.437680274288 0.8761866946656606 0.8987666145441049 0.7398190443713151 0.7135704123127236 0.7437582649842963 0.9016466129768053 0.8535509850860833 0.9038743869334774 0.9121706143655666 1.0 13.110717815202339 -7.9692462543946565 0.813103956109064 0.9867818742268984 0.8005575952321685 0.4963959563943591 0.062216516518803944 0.5705787354509431 0.7360276844888123 0.06530628559338085 0.027041003094398896 1.0733806096592653e-08 7.9692462543946565 -0.18622427899472993 QGS(ph)PDQVS(ph)PVSEMTSTSLYQDK ddPTM_A459_Selumetinib_30min_R2 1 QGSPDQVSPVSEMTSTSLYQDK 22 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 QGS(1)PDQVS(0.999)PVS(0.001)EMTSTSLYQDK 73.166 0.010145 3429800.0 13070.0 10551.0 14570.0 11415.0 10716.0 10280.0 10663.0 12482.0 9694.5 9971.1 True False 12343.621723355467 11360.227773187808 13632.582062616544 9860.257308026656 9369.760277744506 11695.976687451255 11158.850628333657 12518.320553493664 11633.670886962103 9683.20843497092 1.2747450193033603 1.1731883961270864 1.4078579588747109 1.018284112569169 0.9676297211475491 1.2078617088537742 1.1523918650799103 1.2927864392842905 1.2014272919032791 1.0 13.241269434050853 -5.766617213867387 24.99963894574061 1.1309088951725914 1.2740562467480572 0.31484149446380494 0.11050781882711938 184.03645157203266 888571.5052109611 0.03294457818369166 0.05057726571257891 1.7115231829760738e-06 5.766617213867387 0.14314735157546576 QGS(ph)PDQVS(ph)PVSEMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 1 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 QGS(0.986)PDQVS(0.732)PVS(0.039)EMT(0.144)S(0.047)T(0.047)S(0.004)LYQDKQEGK 65.624 0.0031701 5768700.0 38425.0 46529.0 42031.0 42269.0 40745.0 25109.0 16130.0 16930.0 9522.7 41960.0 True False 36289.492327462416 50097.62468568437 39326.771219892675 36511.88928190791 35626.2488350784 28567.53683319197 16880.076960988637 16979.263497087617 11427.50608646903 40748.505774827216 0.8905723446154092 1.2294346438742956 0.9651095291005043 0.8960301387164848 0.874295833863112 0.70106955555754 0.4142502072165912 0.41668432189669935 0.2804398804122158 1.0 15.314459537033763 -6.76349291394995 1.484515458711792 0.4775432024223332 1.0197412052748356 0.5213020510821779 0.20041294283326294 0.2763881177257808 1.2682292521409104 0.08701149205078981 0.07870186685853574 1.723880218029167e-07 6.76349291394995 0.5421980028525024 QGS(ph)PDQVSPVS(ph)EMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 1 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 QGS(0.614)PDQVS(0.284)PVS(0.304)EMT(0.227)S(0.217)T(0.217)S(0.132)LY(0.005)QDKQEGK 57.563 0.017002 3914800.0 20483.0 30801.0 25662.0 22707.0 19268.0 11895.0 9179.0 10017.0 6187.0 25304.0 True False 19344.636859945662 33163.33765917524 24010.934858673023 19614.267428240142 16847.38158189447 13533.428277940922 9605.841687843445 10046.147811596384 7424.572879223741 24573.407772312403 0.7872183231233336 1.3495620129879327 0.9771105042145137 0.7981907763863393 0.6855940265996368 0.550734696763932 0.39090393065737655 0.40882192265232664 0.3021385128190983 1.0 14.584810320086527 -6.1622070066431975 1.3217642048422142 0.48250902202885804 1.0832879339447736 0.4904104477370983 0.22127355905827836 0.31851675701185694 1.1268724472483356 0.08068770294061346 0.12588368157794502 6.883241281613036e-07 6.1622070066431975 0.6007789119159156 QGS(ph)PDQVSPVSEMTSTSLYQDK ddPTM_A459_Selumetinib_30min_R1 2 QGSPDQVSPVSEMTSTSLYQDK 22 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.995)PDQVS(0.005)PVSEMTSTSLYQDK;QGS(0.999)PDQVS(0.001)PVSEMTSTSLYQDK 194.81 3.0114999999999997e-22 67778000.0 8710.0 11209.3 7956.0 8715.1 8072.8 8168.4 9529.400000000001 8709.7 5597.700000000001 9578.3 True False 8912.926053290268 9896.909944937805 6875.618899179776 7193.171387688299 7342.616665368604 8086.2333123137905 8810.589685836048 8478.690462907218 9498.888060167896 10807.768105542807 0.8246777656821891 0.9157219000528087 0.6361737994409399 0.6655556741635908 0.6793832541246804 0.7481871588424194 0.8152089867025831 0.7844996654359088 0.8788945106341015 1.0 13.39978100479455 -8.493453368889748 1.0152906047914338 0.9994686838832192 0.7450394096097622 0.5017709584886969 0.07814803952345223 0.5160004161701892 1.171990833774316 0.0823689103245957 0.027379038560699717 3.210307483159891e-09 8.493453368889748 -0.25442927427345696 QGS(ph)PDQVSPVSEMTSTSLYQDK ddPTM_A459_Selumetinib_30min_R2 2 QGSPDQVSPVSEMTSTSLYQDK 22 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.998)PDQVS(0.002)PVSEMTSTSLYQDK;QGS(0.982)PDQVS(0.018)PVSEMTSTSLYQDK 147.23 2.5889e-07 28214000.0 161486.0 117543.0 134944.0 159030.0 148852.0 116877.0 151307.0 153308.0 120844.0 146850.0 True False 152511.25459967728 126558.1701396849 126261.84995591825 137369.8396579483 130151.88100623601 132975.74584622955 158343.0753091327 153754.1008984944 145016.17666347366 142610.0589378781 1.0694284522111601 0.8874420996825652 0.885364264598746 0.9632549111966046 0.9126416605923363 0.9324429625553601 1.110321926015808 1.07814344965295 1.0168720056882081 1.0 17.121716219668706 -7.246259955406734 24.213849041574456 1.0578462973321203 0.9363829880199936 0.4693379411668418 0.05673733092338197 424.64132999472054 677378.2800037744 0.02139604918996063 0.01650226397700777 5.6720499220060574e-08 7.246259955406734 -0.12146330931212668 QGS(ph)PDQVSPVSEMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R1 2 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.992)PDQVS(0.007)PVS(0.001)EMTSTSLYQDKQEGK;QGS(0.478)PDQVS(0.33)PVS(0.184)EMT(0.007)S(0.001)TSLYQDKQEGK 138.08 1.7927999999999996e-09 60057000.0 3516.95 2747.72 6322.860000000001 6533.99 4068.0499999999997 3999.83 3234.6499999999996 3223.03 2638.95 2051.6 True False 3598.888092206568 2426.015665019627 5464.250340983889 5392.951304682849 3700.0955957725632 3959.5953417550672 2990.6577462683435 3137.5447745230986 4478.105408717878 2314.9428442762946 1.5546336710233832 1.0479808048038681 2.360425595169345 2.3296261149673487 1.598352894509281 1.7104505847931333 1.291892693447165 1.355344380221175 1.9344345454532546 1.0 11.176760858580824 -6.9977446558107745 2.5563028715520613 1.4283176330453518 1.8024628246025063 0.15629291902716747 0.4161751095580983 0.6357995843571651 8.363009940583636 0.18342200218027124 0.14665842117920522 1.0052066295393992e-07 6.9977446558107745 0.37414519155715453 QGS(ph)PDQVSPVSEMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 1 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.932)PDQVS(0.048)PVS(0.013)EMT(0.001)S(0.004)T(0.001)SLYQDKQEGK 64.126 0.0010191 7089700.0 16727.0 25926.0 22192.0 24619.0 23005.0 15385.0 10756.0 10759.0 7363.0 23736.0 True False 15797.380303486372 27914.440834770834 20764.190880822684 21265.849729856192 20114.906232690602 17504.14409887524 11256.175312609661 10790.306908751665 8835.80573940915 23050.680006465645 0.6853325064186937 1.2110029216899856 0.9008060011677916 0.9225693005104919 0.8726383007810803 0.7593764736643509 0.48832291756478935 0.4681123032259793 0.3833208277122728 1.0 14.492521691049399 -6.9554530626661855 2.2213115567191957 0.5408951182848037 0.9408324070756051 0.3778064002380399 0.19728943351041067 0.2741855225385977 2.7362519235750438 0.07902563278732684 0.06407921487125662 1.1080183104255587e-07 6.9554530626661855 0.39993728879080137 QGS(ph)PGSVSK ddPTM_A459_Selumetinib_30min_R2 2 QGSPGSVSK 9 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 QGS(0.795)PGS(0.205)VSK;QGS(0.996)PGS(0.004)VSK 99.732 0.018545 193489000.0 63861.0 45871.0 50660.0 51959.0 42345.0 57789.0 139162.0 337130.0 76283.0 169890.0 True False 60311.861275838026 49389.158201487844 47400.590754437486 44882.094565725536 37025.24253089691 65748.91019368867 145633.30874427152 338110.9924851239 91541.7315251052 164984.83427276948 0.3655600318761687 0.2993557463580727 0.2873027146002406 0.27203769827426655 0.22441603614113442 0.3985148724941953 0.8827072463126878 2.0493458927632395 0.5548493710261831 1.0 17.331973889665235 -7.367218758668198 3.52413401331097 1.2587451968491243 0.29755846952321224 0.568020288765079 0.3517218362994918 0.1577420040486525 3.6271124183963885 0.14864239121835623 0.09580312363476241 4.293201192615247e-08 7.367218758668198 -0.961186727325912 QGS(ph)PSQSLVACECEASK ddPTM_A459_Selumetinib_30min_R1 1 QGSPSQSLVACECEASK 17 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 QGS(0.915)PS(0.085)QSLVACECEASK 143.04 0.00031116 0.0 908.88 1043.3 1451.0 1284.0 987.93 774.18 893.14 876.05 411.88 872.93 True False 930.0551356273777 921.1499509829882 1253.9621697724806 1059.773503665107 898.5719059332076 766.392452099198 825.7697307288605 852.8143081885561 698.9302774750257 984.9790685582501 0.9442384770558967 0.9351974883398376 1.273085093684225 1.0759350502913085 0.9122751280882346 0.7780799374965345 0.8383627196642562 0.865819726947956 0.7095889646650823 1.0 9.943949256467526 -6.42048479593324 3.6674275232444984 0.830756650467613 1.0628934184554155 0.462935793038062 0.1107833892327389 0.2170642203381229 5.331757230024369 0.03694277669161288 0.04167721686240483 3.7976523380960514e-07 6.42048479593324 0.23213676798780247 QGS(ph)PSQSLVACECEASK ddPTM_A459_Selumetinib_30min_R2 3 QGSPSQSLVACECEASK 17 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 QGS(0.499)PS(0.499)QS(0.001)LVACECEASK;QGS(0.861)PS(0.138)QS(0.001)LVACECEASK;QGS(0.972)PS(0.028)QSLVACECEASK 239.13 1.6322999999999995e-22 22839400.0 128853.0 118464.0 121376.0 136099.0 131696.0 92396.0 113005.0 115631.0 88440.0 117169.0 True False 121691.86609942772 127549.80787820292 113566.80030419694 117562.08141612948 115151.1711028221 105122.71031262133 118259.95641515958 115967.46706625744 106130.47122006587 113786.02652837796 1.0694798808980122 1.1209619649245095 0.9980733466940569 1.0331855764979172 1.0119974711842468 0.9238630921557313 1.0393187988304156 1.019171427322277 0.9327197236612985 1.0 16.795963873065475 -5.271764579783803 23.885303784366048 0.9965187306522886 1.0952209212614694 0.5243395851650181 0.038233407486451064 261.15661910135753 604136.5859891811 0.009974583151942516 0.021171440011289473 5.348542119689033e-06 5.271764579783803 0.09870219060918084 QGS(ph)PTPALPEK ddPTM_A459_Selumetinib_30min_R2 2 QGSPTPALPEK 11 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 QGS(0.567)PT(0.433)PALPEK;QGS(0.859)PT(0.141)PALPEK 135.04 0.0015302999999999998 9596800.0 112481.0 85953.0 98092.0 90521.0 80310.0 56862.0 76404.0 73032.0 51414.0 50452.0 True False 106229.7563171189 92545.31871754453 91780.86751449449 78191.88364256505 70220.73981949063 64694.22435815691 79956.93739165376 73244.51102890153 61698.23662718758 48995.31966996144 2.1681613066859393 1.8888603919913431 1.87325785672472 1.5959051633763244 1.4332132189871656 1.3204164151585345 1.6319301094523644 1.4949287303825274 1.259267967691497 1.0 15.580356320380645 -1.5228787452803376 0.18825004710293652 1.0756156210688397 5.843831933419403 0.8518566686268098 0.12554372001024067 22.454740920335254 0.2608406936113541 0.2856145831801824 31.017057196799207 0.029999999999999995 1.5228787452803376 4.768216312350563 up QGS(ph)PVAAGAPAK ddPTM_A459_Selumetinib_30min_R1 9 QGSPVAAGAPAK 12 0 Q9NZI8 Q9NZI8 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 1 QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK 145.86 0.00067197 5276329600.0 78495.59999999999 100012.7 96081.5 103758.2 76415.29999999999 75570.0 77391.4 76028.9 50375.899999999994 70312.8 True False 80324.3947541507 88303.16658935724 83034.16003790108 85638.7781526363 69503.5496072169 74809.83441207018 71553.70438982635 74012.36659532783 85484.22298983712 79338.13278467057 1.0124311215157649 1.1129977917304712 1.0465857605101672 1.0794150951984984 0.876042164942986 0.9429240616880848 0.9018828888250784 0.9328725544399027 1.0774670387296292 1.0 16.275726823743064 -6.24222563375525 24.844571251795283 0.9485622800714343 1.0652766443917572 0.45785667947120123 0.05709428394363056 652.2669640174291 843421.9062286209 0.01674708960022104 0.021584665718808196 5.724985173001241e-07 6.24222563375525 0.1167143643203229 QGS(ph)PVAAGAPAK ddPTM_A459_Selumetinib_30min_R2 8 QGSPVAAGAPAK 12 0 Q9NZI8 Q9NZI8 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 1 QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK;QGS(1)PVAAGAPAK 152.11 0.00050463 5990106600.0 1232563.0 1276056.0 1071975.1 1146749.0 1059105.0 763065.0 902567.0 890518.0 616232.0 898983.0 True False 1164062.0828006256 1373925.3920332626 1003005.3891442426 990559.8079476337 926050.7613811684 868170.277335603 944538.1539025803 893109.25994681 739495.6189606907 873027.024951657 1.333363171506729 1.573748982294497 1.1488824062459957 1.1346267407958934 1.0607355040726802 0.994436887430463 1.0819117013644373 1.0230029935170277 0.8470477978635764 1.0 19.73566678826893 -5.551264124941871 1.6850913313459495 1.0111220410000765 1.4621691376647015 0.76550205572471 0.09333594891790226 0.1758181845258029 0.9677819168069222 0.0276142774192929 0.07777568711707551 2.810191236153127e-06 5.551264124941871 0.45104709666462495 QGS(ph)SLNLFEDVQITEPEAEPESK ddPTM_A459_Selumetinib_30min_R1 2 QGSSLNLFEDVQITEPEAEPESK 23 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 QGS(0.788)S(0.212)LNLFEDVQITEPEAEPESK;QGS(0.781)S(0.219)LNLFEDVQITEPEAEPESK 208.19 4.8439999999999995e-24 12680700.0 7423.6 5446.799999999999 7236.1 5957.4 4983.5 6146.0 6120.7 8047.0 4333.9 5820.5 True False 7596.5554361889435 4809.086123851375 6253.477365052137 4917.0519242480605 4532.743304908383 6084.176820121512 5659.010671196161 7833.5674196601885 7354.311764467837 6567.61787147113 1.1566683057471088 0.732242072843704 0.9521682727943753 0.7486811840267213 0.6901655049996172 0.9263901979666597 0.8616534612615269 1.1927562737302635 1.1197837493581961 1.0 12.681154472835741 -7.75016552975428 24.794168344986417 1.1172024958642721 0.855905880871465 0.39588743394543713 0.13358023158835586 169.34401577869534 372434.2488395956 0.06188473007976095 0.03530697861367943 1.7776017544931856e-08 7.75016552975428 -0.2612966149928071 QGS(ph)VVSSR ddPTM_A459_Selumetinib_30min_R2 1 QGSVVSSR 8 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 1 QGS(0.545)VVS(0.455)SR 87.667 0.032149000000000004 12643000.0 52706.0 56125.0 49240.0 48215.0 55250.0 27835.0 46445.0 59479.0 38926.0 60576.0 True False 49776.81151883495 60429.60702968114 46071.952008458386 41648.033824485814 48309.00105873312 31669.01858902778 48604.784529021555 59652.07404272151 46712.28768331395 58827.01348465049 0.846155678663222 1.027242476714355 0.7831767971780476 0.7079746422169277 0.821204378688002 0.5383414304601926 0.8262323998770364 1.0140251987853557 0.7940618589366671 1.0 15.844191175272838 -11.463694005152076 13.923486656682412 1.0273724680592073 0.8174541737789167 0.1459732610061082 0.1323548366504905 0.07777910692691374 0.00033061598728746216 0.08863074822929044 0.0330727296265064 3.438000969720742e-12 11.463694005152076 -0.20991829428029063 QGSAQSQQQIRGEIDS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 QGSAQSQQQIRGEIDSLR 18 1 Q2M1P5 Q2M1P5 KIF7 Kinesin-like protein KIF7 1 QGSAQSQQQIRGEIDS(1)LR 64.565 0.019283 26538000.0 1112.6 1389.4 950.63 1199.8 1256.5 960.86 1227.2 1189.1 741.51 978.11 True False 1138.5214152572626 1226.7284020854645 821.5396674368117 990.2774530353555 1142.8497968530924 951.1946207910768 1134.631315975612 1157.5612052588453 1258.28831225237 1103.6599460982102 1.03158714718451 1.111509397819809 0.7443775325372787 0.8972668225718456 1.0355089906935835 0.8618547988027047 1.028062420845203 1.0488386475845148 1.1401050810087114 1.0 10.108080009631774 -7.4779657399016894 6.734647028150175 1.065008494523392 0.9465941841915045 0.21666303279056398 0.10147716863911235 0.35629429974590554 42.81335945817618 0.04535222703974628 0.02979268144105915 3.3268579677399545e-08 7.4779657399016894 -0.11841431033188743 QGSFS(ph)EDVISHK ddPTM_A459_Selumetinib_30min_R2 1 QGSFSEDVISHK 12 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 QGS(0.341)FS(0.659)EDVISHK 107.63 0.0055552 1428500.0 15785.0 16551.0 18347.0 18627.0 18126.0 12713.0 18173.0 18068.0 11575.0 11540.0 True False 14907.732892361588 17820.40848014704 17166.573994703205 16089.970466632718 15848.849831504018 14464.100352876249 19018.080509116353 18120.574888681575 13890.323432522191 11206.81021547918 1.3302387214312403 1.5901410068971245 1.5317984033487266 1.4357315022974844 1.4142159567950134 1.2906527437127473 1.6970110266387857 1.6169252927700066 1.239453793313682 1.0 13.452088083101978 -8.516003136130374 4.399599659536336 1.000820968856439 1.4879968260682381 0.6279641762722532 0.12056878280854669 0.10885200787216852 6.599489439060197 0.12045782130157012 0.031458358243488936 3.0478729802266667e-09 8.516003136130374 0.48717585721179923 QGSGRES(ph)PSLASR ddPTM_A459_Selumetinib_30min_R1 3 QGSGRESPSLASR 13 1 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 QGS(0.126)GRES(0.821)PS(0.05)LAS(0.002)R;QGSGRES(0.996)PS(0.004)LASR;QGS(0.047)GRES(0.953)PSLASR 139.21 0.0044949 815478000.0 15351.199999999999 13887.0 17224.7 17428.100000000002 17888.8 14688.0 15318.4 14634.3 8979.0 13387.5 True False 15708.85309176459 12261.103584108858 14885.680348504513 14384.609500954728 16270.761198524166 14540.25205563696 14162.920755085397 14246.150825094208 15236.707199786972 15105.916030292887 1.0399139688227177 0.8116756083855399 0.9854205675877769 0.9522500636246306 1.0771118524619983 0.9625534808003987 0.9375744394900356 0.9430842059842954 1.0086582746277553 1.0 13.882826052015849 -5.4068935143107195 22.88390142896173 0.9811703303256831 0.9189806472415185 0.11186986199170845 0.06403712617455207 19.84563574848086 3875.706607827462 0.01605387327439636 0.03341878149440707 3.918379410000225e-06 5.4068935143107195 -0.062189683084164615 QGSGRES(ph)PSLASR ddPTM_A459_Selumetinib_30min_R2 1 QGSGRESPSLASR 13 1 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 QGS(0.002)GRES(0.754)PS(0.24)LAS(0.003)R 72.615 0.029876 26025000.0 99537.0 81954.0 140170.0 179830.0 259100.0 172930.0 117970.0 132630.0 156610.0 149430.0 True False 94005.13201818152 88239.60827635616 131151.61480555648 155336.843775947 226549.54161661086 196749.53779775748 123455.83875312026 133015.9313419216 187936.376049011 145115.56763423368 0.6477949509533195 0.6080643842345408 0.9037735712554729 1.0704354212876472 1.5611663538927327 1.3558127567241312 0.8507415211598307 0.9166206872938027 1.295080735395033 1.0 17.146842770850242 -5.537284589937548 2.4145588706144 1.1614522852959517 0.6264207737730924 0.5204712171460674 0.2013328436612323 0.2557634205543907 2.961348697796339 0.06389901318627052 0.14728285725747386 2.902120293429874e-06 5.537284589937548 -0.5350315115228593 QGSIT(ph)SPQANEQSVT(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 QGS(0.412)IT(0.319)S(0.269)PQANEQS(0.214)VT(0.786)PQR 131.86 0.0042045 4743600.0 985.12 1678.0 796.56 655.97 1160.9 976.69 1014.2 1212.0 633.55 1049.2 True False 1008.0713792901619 1481.5389799189645 688.3915271908802 541.4171535819322 1055.8967999735412 966.8653853635669 937.6980774628958 1179.8538228691632 1075.0880773387946 1183.8750400734486 0.851501505790358 1.2514318908413244 0.5814731317827021 0.4573262677692252 0.8918988611399666 0.8166954726096614 0.792058321801193 0.9966033432007858 0.9081094211362841 1.0 10.20930109486849 -7.7570497550261575 24.38517335843651 0.9642673063267405 0.8048454405523193 0.1251742028581868 0.19637703899542946 192.46635125250236 1069212.2998389625 0.10379496650984565 0.0572139937469049 1.7496462286042108e-08 7.7570497550261575 -0.1594218657744212 QGSIT(ph)SPQANEQSVT(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 QGS(0.009)IT(0.683)S(0.308)PQANEQS(0.002)VT(0.998)PQR;QGS(0.005)IT(0.917)S(0.077)PQANEQS(0.097)VT(0.903)PQR 108.47 0.012451 25978000.0 50019.0 30742.1 42679.0 52257.0 53784.0 49000.0 60063.0 63333.0 58790.0 50362.0 True False 47239.14422192169 33099.92021856857 39933.0796053817 45139.506451646885 47027.17308493941 55749.30522228707 62856.04851257659 63517.28854465745 70549.64272984701 48907.91820380954 0.9658792677510067 0.6767803953673569 0.8164951826199635 0.9229488416076331 0.9615451814768997 1.1398830142384724 1.2851916585498953 1.2987117603322964 1.4424994013413508 1.0 15.577780436313478 -6.707474569800389 1.34678531464266 1.2880875619003784 0.8172720699950425 0.6931750984107372 0.12468164282722562 0.21488421959479892 0.8163615219360728 0.05544088042050394 0.05252973482802061 1.9612160115068194e-07 6.707474569800389 -0.4708154919053359 QGSIT(ph)SPQANEQSVT(ph)PQRR ddPTM_A459_Selumetinib_30min_R1 2 QGSITSPQANEQSVTPQRR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 QGS(0.028)IT(0.892)S(0.08)PQANEQS(0.009)VT(0.991)PQRR;QGS(0.009)IT(0.681)S(0.31)PQANEQS(0.189)VT(0.811)PQRR 108.49 0.0021245 103732000.0 6187.5 7772.4 5860.0 6308.4 6304.5 6198.6 7320.8 6690.5 4522.700000000001 6700.4 True False 6331.656711220848 6862.403794709268 5064.244186675904 5206.756363334086 5734.259088149882 6136.247711878493 6768.586161990105 6513.046206193178 7674.691575061422 7560.461607422927 0.8374695937883438 0.9076699480851408 0.6698326702305828 0.688682336303652 0.7584535688297043 0.8116234206987932 0.8952609659897814 0.8614614483060944 1.015108861544425 1.0 12.884258606199609 -7.791579273504785 1.0726881030682678 1.0064184277747927 0.771872308017727 0.6090513089822335 0.06947538460651485 0.3912608996902621 0.8134683555932504 0.06710444258972485 0.02638049370519388 1.615923238267939e-08 7.791579273504785 -0.23454611975706574 QGSIT(ph)SPQANEQSVT(ph)PQRR ddPTM_A459_Selumetinib_30min_R2 1 QGSITSPQANEQSVTPQRR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 QGS(0.05)IT(0.656)S(0.293)PQANEQS(0.006)VT(0.994)PQRR 71.524 0.04105 135480000.0 82330.0 91486.0 98706.0 108120.0 118110.0 93706.0 93462.0 101270.0 88156.0 112890.0 True False 77754.42819310285 98502.68202614551 92355.36342296703 93393.86948259658 103271.96588320307 106613.1509216251 97808.1681914395 101564.67893384896 105789.66328444277 109630.57237655493 0.7092403743550192 0.8984964676441918 0.8424234355517941 0.8518962134194726 0.9419996962935525 0.9724764599005676 0.8921614297104252 0.9264266046609558 0.9649649818581667 1.0 16.742290649245533 -2.9001230384318317 0.3611173234871051 0.9612458136854066 1.011770187782883e-18 0.7111951476658724 0.04299836407670686 14.339724309599854 0.5007112870625449 0.03644901738884382 7.921573852204773 0.0012585688006111163 2.9001230384318317 -0.9612458136854066 QGSIT(ph)SPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R1 1 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGS(0.194)IT(0.726)S(0.08)PQANEQSVTPQR 202.84 2.3002e-10 11519000.0 809.9 1582.4 664.93 1027.8 855.45 934.51 1127.5 1239.6 552.86 1012.1 True False 828.769094208931 1397.131872362198 574.6361581990456 848.3140241954806 778.0746985419645 925.1096778671912 1042.4517672445425 1206.721781211727 938.1630407032212 1142.0128936888468 0.7257090517882872 1.2233941316102697 0.5031783453362753 0.7428235082839726 0.6813186635999217 0.810069380984806 0.9128196126379018 1.056662133922028 0.8214995171138877 1.0 10.157363223940731 -7.295505297014344 3.537513424338399 0.957944755422281 0.7807150614767191 0.17668506362810066 0.17840977364967178 0.45524782215437615 12.021896186429203 0.07937050687268539 0.05353664358883187 5.06401172999056e-08 7.295505297014344 -0.17722969394556187 QGSIT(ph)SPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R2 3 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGS(0.001)IT(0.888)S(0.11)PQANEQSVTPQR;QGS(0.052)IT(0.474)S(0.474)PQANEQSVTPQR;QGS(0.001)IT(0.904)S(0.095)PQANEQSVTPQR 233.65 7.5998e-19 32008200.0 85360.0 62132.0 93095.0 92538.0 90528.0 71048.0 81583.0 80082.0 70532.0 78629.0 True False 80616.03292315402 66897.32461413175 87105.36905417216 79934.1647630462 79155.06330941158 80834.21709047041 85376.77115364761 80315.0253617112 84640.37082873892 76358.77646732336 1.0557533351474337 0.8760921495744435 1.1407381454238943 1.0468235409357676 1.0366203725551424 1.0586106906134392 1.1181003036394037 1.0518113185860287 1.1084563522957906 1.0 16.22050636549367 -5.268239512633879 24.999320380890357 1.0712660125958056 0.96592274121556 0.3521328008094883 0.05653076321341417 474.7448341978542 1745310.08738597 0.013695603083508747 0.029549115633232488 5.3921316539802365e-06 5.268239512633879 -0.10534327138024557 QGSITS(ph)PQANEQS(ph)VTPQRR ddPTM_A459_Selumetinib_30min_R2 1 QGSITSPQANEQSVTPQRR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 QGS(0.012)IT(0.112)S(0.876)PQANEQS(0.996)VT(0.004)PQRR 116.85 0.0015591 37385000.0 23649.0 23288.0 21959.0 25266.0 28882.0 20290.0 22441.0 22806.0 19801.0 22535.0 True False 22334.683254447846 25074.114717277764 20546.18184715147 21824.72721371892 25253.584951643967 23084.76332571847 23484.550965997914 22872.36168426345 23761.753286166026 21884.35599703841 1.020577587819828 1.1457552016002217 0.9388524775383826 0.997275278133496 1.1539560476470732 1.054852303117465 1.0731204961743475 1.0451466649216796 1.0857871846620337 1.0 14.417612309171854 QGSITS(ph)PQANEQSVT(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 QGS(0.012)IT(0.09)S(0.897)PQANEQS(0.01)VT(0.99)PQR 186.58 3.2021e-08 12696000.0 33848.0 23009.0 33013.0 31841.0 37032.0 36898.0 34049.0 37343.0 33707.0 26018.0 True False 31966.863664279692 24773.716314404173 30888.97952183667 27504.2008712113 32379.709089719523 41980.364573305116 35632.34596681354 37451.66194753356 40449.34185227002 25266.792737117605 1.2651729879954057 0.9804851993743912 1.2225128785918253 1.0885513312818242 1.2815124351795093 1.6614837114500418 1.4102441230884304 1.482248354082394 1.6008894469953379 1.0 14.62495492567165 -6.534436829602947 7.9138175952216 1.4615742715502276 1.1397643011466212 0.36177552723419093 0.1805786551644234 0.13531810036638284 54.69180626161991 0.05491950559222473 0.056224440661396625 2.9212126349169053e-07 6.534436829602947 -0.32180997040360637 QGSITS(ph)PQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R1 1 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGSIT(0.23)S(0.758)PQANEQS(0.009)VT(0.002)PQR 190.37 2.2889e-10 10579000.0 1028.7 1545.1 788.84 862.65 1326.5 1076.9 1289.9 1418.7 834.48 932.29 True False 1052.6667084982435 1364.1989737024974 681.7198607879553 712.0043714460317 1206.5183092125967 1066.0673637469665 1192.6018044955524 1381.0714674129383 1416.051611992229 1051.9585027736146 1.0006732259141036 1.2968182396032006 0.6480482442895982 0.6768369375491019 1.1469257637363706 1.0134119938535144 1.1336966252481586 1.3128573644032326 1.3461097640816053 1.0 10.038862079574125 -7.12697115339511 1.509638813145514 1.2401862850838914 0.9348293278151376 0.2593766324057535 0.20009771826600514 0.5585676111332948 2.526791837314846 0.1146447508334159 0.07656020421476702 7.464983404987902e-08 7.12697115339511 -0.3053569572687538 QGSITS(ph)PQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R2 1 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGSIT(0.162)S(0.837)PQANEQS(0.001)VTPQR 144.41 0.00028510000000000005 25825000.0 16514.0 12091.0 17218.0 16423.0 15601.0 15173.0 17177.0 20335.0 14745.0 15838.0 True False 15596.217990779798 13018.340821307347 16110.212625540955 14186.159068744786 13641.062905290415 17262.94302321963 17975.764535579787 20394.171483359518 17694.412009722644 15380.715787934074 1.0140111946555037 0.8464066952930779 1.0474293165327948 0.9223341269899547 0.8868938931952446 1.122375789347992 1.1687209349308363 1.3259572418182528 1.1504283840680307 1.0 13.908835024570475 -6.895654472181262 4.413318283305651 1.1835330931452483 0.9431941426416639 0.5624459848154575 0.0920624175137086 0.14535004137800023 4.978957479513307 0.032394609526807866 0.02841458106567642 1.2715853853582192e-07 6.895654472181262 -0.24033895050358445 QGSITSPQANEQSVT(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGSITSPQANEQSVT(1)PQR;QGSITSPQANEQS(0.001)VT(0.999)PQR 290.67 2.0749999999999994e-80 16813400.0 3727.19 4979.3 2096.39 2062.8199999999997 2962.7799999999997 2676.28 3894.8 3541.88 1778.94 4048.5600000000004 True False 3814.0262751507425 4396.321241186231 1811.711752645989 1702.5872109271468 2694.7970721212923 2649.359053067816 3601.012100278531 3447.937836752333 3018.7312513630714 4568.232112313922 0.8349020324229638 0.9623681838179161 0.3965892511815282 0.3727015547957226 0.5898993321414904 0.5799528106127363 0.7882725771687047 0.7547641520793626 0.6608095160545618 1.0 12.157420240699262 -9.088580667924287 0.641774841821878 1.005755446285887 0.6304686401685193 0.2568003707660006 0.17556222708846694 3.034282661636394 2.0270560530953565 0.2566116634803883 0.07823432818335581 8.154912998285119e-10 9.088580667924287 -0.37528680611736775 QGSITSPQANEQSVT(ph)PQR ddPTM_A459_Selumetinib_30min_R2 4 QGSITSPQANEQSVTPQR 18 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGSITSPQANEQS(0.019)VT(0.981)PQR;QGSITSPQANEQSVT(1)PQR;QGSITSPQANEQS(0.001)VT(0.999)PQR;QGSITSPQANEQSVT(1)PQR 246.9 2.1429999999999996e-32 45284900.0 74760.0 54071.0 72126.0 80372.0 84972.0 73201.0 86754.0 88915.0 78750.0 63690.7 True False 70605.13848799198 58218.07183433213 67485.49168485125 69425.19495056682 74297.05770068179 83283.77329748232 90788.23289978974 89173.72792932943 94502.20045884408 61851.78400268802 1.141521455305534 0.9412512957072026 1.09108399657346 1.1224445029354313 1.2012112326049142 1.346505596247036 1.467835315725803 1.4417325121204914 1.5278815636867822 1.0 15.916527587276764 -6.519948102990555 1.5997261412676878 1.398823602115131 1.052984904925704 0.45591116954405175 0.14368862433896454 0.29137947287634497 1.5172605456043549 0.05409434767106014 0.05957945680922364 3.020312617982009e-07 6.519948102990555 -0.34583869718942695 QGSITSPQANEQSVT(ph)PQRR ddPTM_A459_Selumetinib_30min_R1 5 QGSITSPQANEQSVTPQRR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGSITSPQANEQS(0.068)VT(0.932)PQRR;QGSITSPQANEQS(0.034)VT(0.966)PQRR;QGSITSPQANEQS(0.011)VT(0.989)PQRR;QGSITSPQANEQS(0.001)VT(0.999)PQRR;QGSITSPQANEQS(0.002)VT(0.998)PQRR 222.93 2.051e-17 170220000.0 6948.110000000001 7647.129999999999 7267.7300000000005 6778.14 8448.47 7884.360000000001 7933.650000000001 7763.580000000001 5062.91 6607.08 True False 7109.9874443314175 6751.80046454571 6280.812184783291 5594.465090445956 7684.307380198523 7805.050496826106 7335.208393081745 7557.664638738094 8591.388489684085 7455.163076409153 0.9536997878463589 0.9056542955996311 0.8424781752471739 0.7504148511719184 1.030736323463462 1.0469322289574219 0.9839098511866242 1.0137490704466672 1.152407855016661 1.0 12.864024195447609 -6.338333298006997 9.982241881013827 1.0366461111889693 0.8647183979000732 0.6397129676501352 0.06429371302313633 0.36293621539053944 45.57406443708349 0.02078624908692818 0.023570260577341406 4.588457378826806e-07 6.338333298006997 -0.1719277132888961 QGSITSPQANEQSVT(ph)PQRR ddPTM_A459_Selumetinib_30min_R2 1 QGSITSPQANEQSVTPQRR 19 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QGSITSPQANEQS(0.045)VT(0.955)PQRR 159.5 0.00026724 19533000.0 15193.0 16167.0 14323.0 17919.0 18197.0 14604.0 15621.0 18392.0 9420.2 16867.0 True False 14348.633882397819 17406.956914901653 13401.47377370329 15478.401288000841 15910.93017675595 16615.56843808737 16347.407452424275 18445.51767504049 11304.50322237974 16380.005884270997 0.8759846598209213 1.062695400593036 0.8181604981334066 0.9449570041280677 0.9713629097065539 1.0143811031254009 0.998009864460548 1.1260995756267043 0.6901403639442499 1.0 13.99964825479498 -6.185840032171129 4.486714244298339 0.9769857238670125 0.9262987383562851 0.02534204903002424 0.11827607222778591 0.9170540722632846 34.74537342985853 0.03436395939964027 0.04463650395461181 6.518684587724838e-07 6.185840032171129 -0.05068698551072748 QGSPDQVS(ph)PVSEMTSTSLYQDK ddPTM_A459_Selumetinib_30min_R2 5 QGSPDQVSPVSEMTSTSLYQDK 22 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.044)PDQVS(0.909)PVS(0.044)EMT(0.002)S(0.001)TSLYQDK;QGS(0.002)PDQVS(0.998)PVSEMTSTSLYQDK;QGS(0.011)PDQVS(0.987)PVS(0.002)EMTSTSLYQDK;QGS(0.019)PDQVS(0.978)PVS(0.003)EMTSTSLYQDK;QGS(0.01)PDQVS(0.939)PVS(0.049)EMT(0.001)S(0.001)TSLYQDK 91.66 0.00023311 26979300.0 190600.0 163655.0 204054.0 203668.0 216541.0 184252.0 204247.0 197980.0 191421.0 191827.0 True False 180007.2150322535 176206.8122662355 190925.38779719666 175928.06705310344 189337.1836788982 209631.04052687448 213744.8902077526 198556.0890226464 229710.5487496184 186288.4560835982 0.966282177739849 0.9458815429076374 1.0248911382437869 0.9443852332650958 1.0163656281199296 1.12530344034201 1.1473866642162365 1.065852888563009 1.2330906250386995 1.0 17.50717875061141 -6.650177801081685 3.635133342526987 1.1209094308142706 0.973020217224651 0.568325912328596 0.05953202020310701 0.16031495037933005 4.067420272197985 0.019285362102546104 0.01909479620993994 2.2378047889781924e-07 6.650177801081685 -0.1478892135896196 QGSPDQVS(ph)PVSEMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R1 4 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.031)PDQVS(0.718)PVS(0.241)EMT(0.009)STSLYQDKQEGK;QGS(0.001)PDQVS(0.819)PVS(0.137)EMT(0.042)S(0.001)TSLYQDKQEGK;QGS(0.068)PDQVS(0.771)PVS(0.126)EMT(0.033)S(0.002)TSLYQDKQEGK;QGS(0.002)PDQVS(0.783)PVS(0.02)EMT(0.182)S(0.008)T(0.003)S(0.002)LYQDKQEGK 143.09 5.4443e-10 146110400.0 7866.870000000001 6629.629999999999 14953.0 15738.900000000001 10111.51 9925.02 7292.11 8378.220000000001 5477.23 6184.26 True False 8050.152764735666 5853.42983756863 12922.464730949625 12990.396570743587 9196.925705832089 9825.183309997143 6742.0602717885595 8156.002389306002 9294.459268948565 6978.070010793589 1.153635998533089 0.8388322026741807 1.8518680252507245 1.8616030722893593 1.3179755565086626 1.4080087036673 0.9661783646996988 1.1688048954353285 1.3319527110751275 1.0 12.768612356788532 -7.2293880129543595 19.022015619282122 1.1308019914719132 1.4166397496255085 0.18283272882678825 0.2977202759934163 72.51102821479954 43033.27037930422 0.12506811395659315 0.09683015548929265 5.8967401062758325e-08 7.2293880129543595 0.28583775815359536 QGSPDQVS(ph)PVSEMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 4 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.002)PDQVS(0.826)PVS(0.171)EMT(0.001)STSLYQDKQEGK;QGSPDQVS(0.606)PVS(0.39)EMT(0.003)STSLYQDKQEGK;QGS(0.016)PDQVS(0.692)PVS(0.29)EMT(0.002)STSLYQDKQEGK;QGS(0.016)PDQVS(0.437)PVS(0.437)EMT(0.093)S(0.015)T(0.001)SLYQDKQEGK 118.37 4.2637e-09 68181400.0 107451.0 155700.0 129635.0 163882.0 134698.0 71340.6 57257.6 49188.1 35438.1 144794.0 True False 101479.30358043355 167641.68934559225 121294.42523591622 141560.98888778142 117776.03302460136 81167.12008451222 59920.19185378195 49331.229227471675 42526.7102232453 140613.42100000795 0.7216900268746596 1.192216846396069 0.8626091618659172 1.0067388154063432 0.8375874236399861 0.5772359388404869 0.42613422977440085 0.3508287393666988 0.3024370641209483 1.0 17.101374775007237 -6.751825997344631 2.44124544417659 0.46721422635158677 0.9569152560821286 0.4607892993752284 0.21213284317735745 0.22034086759290455 2.693295062567275 0.07626730716786995 0.07095784961493976 1.7708183050438069e-07 6.751825997344631 0.4897010297305418 QGSPDQVSPVS(ph)EMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R1 4 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGSPDQVS(0.178)PVS(0.794)EMT(0.023)S(0.005)TSLYQDKQEGK;QGS(0.001)PDQVS(0.151)PVS(0.847)EMT(0.001)S(0.001)TSLYQDKQEGK;QGSPDQVS(0.029)PVS(0.967)EMT(0.004)STSLYQDKQEGK;QGSPDQVS(0.188)PVS(0.704)EMT(0.095)S(0.006)T(0.006)SLYQDKQEGK 138.44 1.7029e-09 68980600.0 5755.0199999999995 4963.26 11184.619999999999 10383.59 8112.24 6535.099999999999 5305.58 5974.63 4078.08 4117.6 True False 5889.100768680431 4382.159211843027 9665.810036719973 8570.290930624587 7378.489324332301 6469.362827396042 4905.375829053037 5816.163404066656 6920.20390882139 4646.134068820466 1.2675270841195339 0.943183977675346 2.0803984330942633 1.8446068933177306 1.58809221065063 1.392418456198025 1.0557973051127183 1.2518285778919052 1.4894542013459915 1.0 12.18181506981004 -6.989470040430317 4.597484001528236 1.2189848875057103 1.5548633321607894 0.21335108259730362 0.31105465644530955 0.35646260423686454 19.445671223305187 0.12659099987077455 0.10589243173309293 1.0245424553791535e-07 6.989470040430317 0.3358784446550791 QGSPDQVSPVS(ph)EMTSTSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 2 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGSPDQVS(0.114)PVS(0.873)EMT(0.01)S(0.002)TSLYQDKQEGK;QGSPDQVS(0.067)PVS(0.892)EMT(0.004)S(0.034)T(0.002)SLYQDKQEGK 111.88 8.8619e-09 24031600.0 49644.0 72843.0 67721.0 70872.0 67489.0 37285.0 27004.0 25844.0 20834.0 64149.0 True False 46884.98522067779 78429.82387283846 63363.90458904978 61219.11133898078 59010.428460684896 42420.670310468886 28259.739507410854 25919.20176129547 25001.382150597623 62296.85169088156 0.7526060137568779 1.2589693017234496 1.0171285204501659 0.98269992266626 0.9472457573537749 0.6809440470757856 0.4536302997723921 0.4160595769736031 0.40132657545288275 1.0 15.926871634857768 -6.832798767006747 2.4202755682502195 0.5198578797737589 1.0190474229820294 0.5075767439487642 0.19783305223306455 0.20545818640203622 2.4599229938245375 0.07399033833823175 0.06544850323301074 1.4696070712938437e-07 6.832798767006747 0.4991895432082706 QGSPDQVSPVSEMT(ph)STSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R1 2 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.08)PDQVS(0.244)PVS(0.244)EMT(0.403)S(0.026)T(0.002)SLYQDKQEGK;QGSPDQVS(0.095)PVS(0.155)EMT(0.731)S(0.013)T(0.005)S(0.001)LYQDKQEGK 113.08 1.9578e-08 19719000.0 3430.5 2806.7999999999997 5302.4 5250.0 3696.4700000000003 3496.6299999999997 3177.99 3073.64 2283.77 2901.85 True False 3510.423975408989 2478.1785511540797 4582.363203998343 4333.186054705461 3362.124941164784 3461.4570768860203 2938.2716556855707 2992.1170826102075 3875.390890038699 3274.3307139126364 1.07210428088195 0.756850412398569 1.3994808723895464 1.323380694654253 1.0268128771718477 1.0571494999507178 0.897365572512529 0.9138102849222582 1.1835673389899675 1.0 11.676984328901124 -6.495920728259232 24.281906744053067 1.0028230675381504 1.1351233602104422 0.10834160644274615 0.17523125491371463 1265.180496058824 1139587.6892191248 0.058207579352130064 0.06579117924375143 3.1921204594472837e-07 6.495920728259232 0.13230029267229182 QGSPDQVSPVSEMT(ph)STSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 3 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGS(0.093)PDQVS(0.018)PVS(0.091)EMT(0.79)S(0.008)T(0.001)SLYQDKQEGK;QGS(0.002)PDQVS(0.042)PVS(0.238)EMT(0.339)S(0.238)T(0.112)S(0.027)LY(0.002)QDKQEGK;QGS(0.01)PDQVS(0.088)PVS(0.006)EMT(0.885)S(0.011)T(0.001)SLYQDKQEGK 112.64 3.569100000000001e-07 9568700.0 62983.0 82727.0 71258.0 82426.0 70923.0 41885.2 35382.6 32522.0 22193.5 77644.0 True False 59482.65700092554 89071.89489076944 66673.33785984406 71199.43660721893 62013.01868033534 47654.50610401101 37027.961009291794 32616.63363569306 26632.820138201412 75402.2159766609 0.7888714705591291 1.1812901482675218 0.8842357879837555 0.944261858686715 0.8224296577640385 0.6320040530209539 0.49107258360620315 0.4325686349296262 0.3532100455302934 1.0 16.20231930266622 -6.6965327365750715 1.8150651502513127 0.5215163122879517 0.9654733710916288 0.45900735821399974 0.1875374730583371 0.26662899907925364 1.8116444478474754 0.07216468365292608 0.0692142588923526 2.0112555865552786e-07 6.6965327365750715 0.4439570588036771 QGSPDQVSPVSEMTS(ph)TSLYQDKQEGK ddPTM_A459_Selumetinib_30min_R2 1 QGSPDQVSPVSEMTSTSLYQDKQEGK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QGSPDQVS(0.006)PVS(0.232)EMT(0.232)S(0.498)T(0.029)S(0.002)LYQDKQEGK 90.1 2.4894000000000006e-05 14615000.0 40378.0 56452.0 49402.0 62359.0 54652.0 33545.0 25714.0 24909.0 20513.0 59561.0 True False 38133.95240594086 60781.68687821045 46223.52910483066 53865.596624724894 47786.12716492093 38165.51925880859 26909.75195132436 24981.48106609307 24616.17318110824 57841.31917193716 0.6592856620815503 1.050835073410633 0.7991437568605265 0.9312650090950698 0.8261590131247438 0.6598314112677661 0.4652340634094692 0.43189680705299893 0.42558111629395984 1.0 15.819812835384628 -6.869224882275405 2.7909731178492385 0.5348269394597754 0.8697734458210692 0.32633144361328104 0.18199595477587419 0.2545308980389849 4.010016578870232 0.06603794889882818 0.05759454360540361 1.3513726269556858e-07 6.869224882275405 0.33494650636129375 QGSPS(ph)QSLVACECEASK ddPTM_A459_Selumetinib_30min_R2 1 QGSPSQSLVACECEASK 17 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 QGS(0.341)PS(0.657)QS(0.003)LVACECEASK 142.23 0.00049936 8211800.0 25409.0 25515.0 26004.0 34750.0 30003.0 23666.0 23257.0 29243.0 21782.0 25455.0 True False 23996.86950028606 27471.918456344145 24330.930951014467 30016.99005290637 26233.754909776842 26925.776681441777 24338.496582871234 29328.09228856075 26139.008639930747 24720.048009967286 0.970745262736155 1.1113214037961126 0.9842590492220757 1.2142771745752 1.061233978963116 1.0892283328327326 0.9845651016963152 1.1864091961607628 1.0574012085005389 1.0 14.593393924720315 -4.751424982426442 24.685052772401423 1.080814348561083 0.9707449986670211 0.15024785700253984 0.0748421315261781 645.3580493604808 1590649.5699358804 0.017506068093231724 0.22973083461405738 1.7724541824092007e-05 4.751424982426442 -0.11006934989406192 QGSPVAAGAPAK ddPTM_A459_Selumetinib_30min_R2 1 QGSPVAAGAPAK 12 0 Q9NZI8 Q9NZI8 IGF2BP1 Insulin-like growth factor 2 mRNA-binding protein 1 0 119.03 0.043323 0.0 40903.0 35523.0 37032.0 38682.0 30586.0 26623.0 32495.0 30794.0 19018.0 31489.0 False True 38629.775007682365 38247.49987555215 34649.40143739298 33413.44486982806 26743.513237690688 30290.076590468347 34006.08188762095 30883.605441778862 22822.131407318106 30579.83075175247 1.2632435843507266 1.2507426933146208 1.1330802226695547 1.092662845032692 0.8745474575969675 0.9905246643241308 1.1120428416914026 1.0099338250918535 0.7463132020771637 1.0 14.900292801477628 -5.689048894928761 1.5462566277637688 0.9659524355170866 1.2637076125532534 0.6166157413294531 0.09368295991702438 0.29044727818313765 1.386509890802055 0.031164486557756752 0.07686090208906819 2.0462142512686087e-06 5.689048894928761 0.2977551770361667 QGSVVS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 QGSVVSSR 8 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 1 QGS(0.178)VVS(0.821)S(0.001)R 101.46 0.017015 11871000.0 57183.0 54856.0 41666.0 41894.0 42726.0 25637.0 49391.0 61613.0 45358.0 54955.0 True False 54004.99778168594 59063.2788101593 38985.254922510736 36187.96492881898 37358.37790471367 29168.264040485203 51687.779366409784 61792.283629418765 54430.86740840963 53368.30635976242 1.0119301410397306 1.1067107584791311 0.7304945122242827 0.6780796955569732 0.7000105578182709 0.5465465560000778 0.9685107677574778 1.157846067155837 1.0199099638179325 1.0 15.70369560775516 -7.51231879262574 24.003801473418687 1.0659625649224027 0.7938195492251231 0.3697545117818116 0.15739677671358443 355.81625047897546 808814.049060581 0.07827164572585817 0.04892915427154107 3.073839643184061e-08 7.51231879262574 -0.2721430156972796 QGTALLLPS(ph)PEFDYRPESEK ddPTM_A459_Selumetinib_30min_R2 1 QGTALLLPSPEFDYRPESEK 20 1 Q5THK1-2;Q5THK1-4;Q5THK1;Q5THK1-3 Q5THK1-2 PRR14L Protein PRR14L 1 QGT(0.007)ALLLPS(0.99)PEFDY(0.002)RPES(0.001)EK 56.468 0.0228 1542000.0 13223.0 8699.1 14375.0 12450.0 11459.0 8368.3 8295.6 9890.3 9585.0 10386.0 True False 12488.118595862994 9366.292997984841 13450.128150316606 10754.288522552068 10019.417975240236 9520.957365136024 8681.361837419556 9919.079135572696 11502.267827276477 10086.129193931252 1.2381477924531248 0.9286310752018196 1.3335272522990729 1.0662453668571727 0.9933858453120791 0.9439654382837682 0.8607228472388659 0.9834376443979055 1.1404045700899117 1.0 13.300084989656927 -6.075097534253034 4.314820877456397 0.9792015427016363 1.1505950718443847 0.3200239447069244 0.11548796962081641 0.2731465885708287 9.53086559052823 0.034202907799621436 0.046009789292609925 8.412062015696087e-07 6.075097534253034 0.1713935291427484 QGTPEAS(ph)GHDENGTPDAFSQLLTCPYCDR ddPTM_A459_Selumetinib_30min_R1 1 QGTPEASGHDENGTPDAFSQLLTCPYCDR 29 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMN2;F6TDF5 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 QGT(0.129)PEAS(0.87)GHDENGT(0.001)PDAFSQLLTCPYCDR 85.15700000000002 3.0239e-06 4251100.0 373.75 380.02 447.64 300.91 375.65 388.22 429.65 446.84 258.2 351.73 True False 382.45764780909724 335.52708173349504 386.8529467105123 248.36171728027068 341.67252382639396 384.31485927555724 397.2411545868005 434.98835165912266 438.1465418181309 396.8779716403301 0.9636655978369562 0.845416238010725 0.9747402837996185 0.6257886177299556 0.8609007005710915 0.9683451507453326 1.0009150997848768 1.0960254353782326 1.1039830202901773 1.0 8.632551678826493 -7.078467838426444 2.003521468765187 1.0655654057981923 0.8488602986576083 0.49179002364817803 0.09427629899032872 0.2859218700475855 2.274378380522501 0.044641024305742044 0.032703795642659454 8.347033597454211e-08 7.078467838426444 -0.216705107140584 QGTPEAS(ph)GHDENGTPDAFSQLLTCPYCDR ddPTM_A459_Selumetinib_30min_R2 1 QGTPEASGHDENGTPDAFSQLLTCPYCDR 29 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMN2;F6TDF5 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 QGT(0.092)PEAS(0.863)GHDENGT(0.04)PDAFS(0.005)QLLTCPYCDR 52.39100000000001 0.0098801 5527900.0 3446.6 3435.5 4255.5 4199.3 3953.3 3175.5 2994.3 5308.9 3767.6 2848.3 True False 3255.051769832972 3698.9918031264065 3981.705763038073 3627.3480958034474 3456.6511110495853 3612.8963006810777 3133.540883092888 5324.3480200642925 4521.225275539577 2766.0621782278463 1.1767818509121186 1.337277170499568 1.4394852705693921 1.3113761955009295 1.249665006903129 1.3061515135555553 1.1328526552141633 1.924883707233032 1.6345349396434117 1.0 11.433617871813086 -7.736117186720005 24.9999586129559 1.5847826587757479 1.2886432536796957 0.17129058318255175 0.22898911276612946 283.6105869684407 280001.94125421514 0.10231760154125835 0.05904454178902809 1.836042852662148e-08 7.736117186720005 -0.2961394050960522 QGVLTHGR ddPTM_A459_Selumetinib_30min_R1 1 QGVLTHGR 8 0 P62753;A2A3R5 P62753 RPS6 40S ribosomal protein S6 0 98.582 0.027178 2238800.0 4285.5 4033.1 4449.1 3561.8 4077.3 4439.5 3680.4 4685.5 4494.6 4095.3 False True 4385.343811868597 3560.9027770626753 3844.936657156958 2939.7984932666523 3708.5089349057816 4394.842660743485 3402.7844648929618 4561.2253193510405 7627.007927404225 4620.971646600072 0.9490090282408808 0.7705961103835481 0.8320623780468142 0.6361862218803355 0.8025387772362456 0.9510646238171654 0.7363785638885267 0.9870706137543627 1.6505203906662953 1.0 12.173980522092316 -8.039541415382295 6.98576675915589 1.327570667564502 0.8118852154240075 0.5894004555778714 0.16991576770297612 0.14355270794890282 20.131969833466687 0.10452529863493655 0.0403920066459395 9.12974367676663e-09 8.039541415382295 -0.5156854521404945 QGVLTHGR ddPTM_A459_Selumetinib_30min_R2 4 QGVLTHGR 8 0 P62753;A2A3R5 P62753 RPS6 40S ribosomal protein S6 0 ;;; 109.48 0.017469 9794100.0 102319.7 78780.7 69486.75 93326.1 89279.4 78248.2 128108.6 158029.5 113581.1 134301.7 False True 96633.18069221229 84822.92637012372 65016.048156453035 80614.92418349767 78063.32360403723 89026.17928356254 134065.90374237517 158489.33968180782 136300.4937210926 130424.06096327728 0.740915288011318 0.6503625615062454 0.49849734532310885 0.6180985593309806 0.5985346800849657 0.6825901495938629 1.0279230898976786 1.215184824880071 1.0450563547432394 1.0 16.992850520618262 -7.264302406912584 3.2821096157915997 1.1023112680211893 0.6175412730587181 0.8900430234067037 0.07619765933914557 0.0738436766164743 1.6671366643211112 0.03365681665080192 0.023162884034966656 5.441236380080283e-08 7.264302406912584 -0.4847699949624712 QGYACPYYHNS(ph)KDR ddPTM_A459_Selumetinib_30min_R2 1 QGYACPYYHNSKDR 14 1 Q9C0B0 Q9C0B0 UNK RING finger protein unkempt homolog 1 QGYACPY(0.322)Y(0.038)HNS(0.641)KDR 56.746 0.044212 2768700.0 26993.0 22598.0 23661.0 24817.0 23835.0 18587.0 25187.0 23804.0 18114.0 24205.0 True False 25492.83712154046 24331.19393597747 22138.67702014895 21436.881788287137 20840.634212396446 21147.190534013273 26358.24540709369 23873.265699035655 21737.306147447685 23506.138757857312 1.0845182777209235 1.0350995621449894 0.9418253354242935 0.9119695075875236 0.8866038964153619 0.8996454395107524 1.1213345449295884 1.015618343146878 0.9247501842548103 1.0 14.52074995331735 -10.193169608395934 16.04473072693669 0.9999945329413055 0.9787115424320018 0.005609816502957221 0.0771623571145799 0.0 0.0 0.08091909617769501 0.019625763568832406 6.40959208922983e-11 10.193169608395934 -0.021282990509303712 QHEAPSNRPLNELLTPQGPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 QHEAPSNRPLNELLTPQGPSPR 22 1 P10398;Q96II5 P10398 ARAF Serine/threonine-protein kinase A-Raf 1 QHEAPSNRPLNELLT(0.004)PQGPS(0.996)PR;QHEAPSNRPLNELLT(0.001)PQGPS(0.999)PR 98.169 7.3317e-05 14068700.0 41305.0 28089.0 41564.0 42044.0 41033.0 29106.0 34731.0 42752.0 35860.0 44045.0 True False 39009.433457015875 30243.335979629665 38889.8174914615 36317.534670054556 35878.06770032574 33115.08730203853 36346.06031817091 42876.401242025386 43033.00201211627 42773.30640734665 0.9120041617899265 0.7070609807811148 0.9092076521066389 0.8490700794600422 0.8387957516925415 0.7741998476028675 0.8497369825010345 1.0024102610562047 1.0060714409659248 1.0 15.384423112438466 -7.738569204815474 4.958359821357117 1.005076648386523 0.829494220768602 0.6529669610066873 0.0563785035154363 0.10639392760636751 6.681389465860939 0.027979647668169867 0.014721276057081076 1.8257057997179636e-08 7.738569204815474 -0.17558242761792098 QHEEFDLS(ph)PDQWR ddPTM_A459_Selumetinib_30min_R2 3 QHEEFDLSPDQWR 13 0 Q86US8 Q86US8 SMG6 Telomerase-binding protein EST1A 1 QHEEFDLS(1)PDQWR;QHEEFDLS(1)PDQWR;QHEEFDLS(1)PDQWR 189.33 0.00015533 6604900.0 32468.4 31935.4 34456.3 36872.6 43264.0 32443.3 31399.8 35756.4 29031.8 30729.6 True False 30663.93630930332 34384.742491504345 32239.419171182875 31850.488271217164 37828.789534932635 36912.07008404545 32859.95291752332 35860.4452042093 34838.97121626764 29842.35660291066 1.0275306577602028 1.1522127072280426 1.0803241714509377 1.067291323370576 1.2676207190434492 1.2369019838213866 1.1011178961087256 1.201662646197039 1.1674336474107287 1.0 14.865073846948508 -4.760584155575616 24.009300339237768 1.1493316990812485 1.02753043456997 0.15519514254627143 0.07800804208387242 23.352700815409232 654949.3248480482 0.019542903522547804 0.11431775901166506 1.7354649399193162e-05 4.760584155575616 -0.12180126451127848 QHEVEIPS(ph)PTQK ddPTM_A459_Selumetinib_30min_R1 2 QHEVEIPSPTQK 12 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;Q08499-3;Q08499-5;Q08499-8;D6RHE0;Q08499-6;Q08499-9;Q08499-4 A0A1B0GW84;Q08499-6;Q08499-9;Q08499-4 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 QHEVEIPS(0.963)PT(0.037)QK;QHEVEIPS(0.897)PT(0.103)QK 175.6 0.00010345 31472000.0 9675.0 11358.3 7469.8 9051.3 9160.1 9019.2 10241.4 10115.1 5710.3 9980.5 True False 9900.408675727142 10028.464955669586 6455.442188674345 7470.660368943913 8331.570572347004 8928.475036778384 9468.88295260156 9846.81468952464 9689.962036189274 11261.594393302576 0.8791302838623855 0.8905013451411153 0.5732263091017986 0.6633750167193748 0.7398215813297185 0.7928251298136141 0.8408119331870836 0.874371278669091 0.8604431750758158 1.0 13.459123475215614 -8.083327219165593 0.7635663397175354 0.9833754080676657 0.7458043842506317 0.4096609228590824 0.0901793314201212 0.6776187340944577 0.8174947184181951 0.0944658045254905 0.03932322347016744 8.254158057130787e-09 8.083327219165593 -0.237571023817034 QHEVEIPS(ph)PTQK ddPTM_A459_Selumetinib_30min_R2 1 QHEVEIPSPTQK 12 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;Q08499-3;Q08499-5;Q08499-8;D6RHE0;Q08499-6;Q08499-9;Q08499-4 A0A1B0GW84;Q08499-6;Q08499-9;Q08499-4 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 QHEVEIPS(0.967)PT(0.033)QK 84.046 0.02201 30510000.0 131690.0 91874.0 129270.0 123740.0 119950.0 91420.0 106570.0 111480.0 88837.0 120600.0 True False 124371.19699683867 98920.44037852874 120952.90893853422 106886.39853659381 104880.80863339426 104012.27517186706 111525.71616444884 111804.38834349261 106606.88231317293 117117.96464356933 1.0619309973097932 0.8446222633699111 1.0327442874083064 0.9126387985129888 0.8955142701854751 0.8880983842949506 0.9522511469855232 0.9546305614493236 0.9102521772608901 1.0 16.837602861243944 -4.73338306446104 24.88373922393736 0.9315041669073764 1.0619317553872962 0.3551967414490138 0.05238498133730097 3359.058203103927 2979051.117834743 0.012369018066139338 1.2342197055022512 1.847638211973257e-05 4.73338306446104 0.13042758847991986 QHEVEIPSPT(ph)QK ddPTM_A459_Selumetinib_30min_R2 1 QHEVEIPSPTQK 12 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;Q08499-3;Q08499-5;Q08499-8;D6RHE0;Q08499-6;Q08499-9;Q08499-4 A0A1B0GW84;Q08499-6;Q08499-9;Q08499-4 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 QHEVEIPS(0.018)PT(0.982)QK 181.58 0.00024347 16921000.0 45465.0 38469.0 39178.0 45665.0 48107.0 35963.0 36911.0 39169.0 31577.0 40894.0 True False 42938.23731081531 41419.448602669116 36657.33013378115 39445.34822348116 42063.36857796333 40916.57681039002 38627.43463775894 39282.97530522297 37893.282335097465 39713.28396462786 1.0812059095656728 1.0429620637658905 0.9230495812542572 0.9932532464103108 1.0591762850795383 1.030299504992685 0.9726577805090088 0.9891646165603389 0.954171464864214 1.0 15.277334044455916 -7.2670400487080835 24.349430325039492 0.9780955144301586 1.0185582251246057 0.19955650882404663 0.041562565274016104 654.7925234403518 2846757.364709532 0.018512185150966535 0.01284442694578277 5.4070445928296494e-08 7.2670400487080835 0.04046271069444707 QHFISFDTDR ddPTM_A459_Selumetinib_30min_R1 1 QHFISFDTDR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 107.45 0.015847999999999998 4611900.0 1440.7 1471.2 1763.5 1930.6 1833.8 1397.3 1338.1 1329.6 831.41 1269.6 False True 1474.2655068857982 1298.951220057676 1524.026386212109 1593.4569518503547 1667.933113783685 1383.2444306468913 1237.16603968951 1294.3346888505262 1410.8420462161575 1432.5655269512488 1.0291086021197888 0.9067307537562156 1.06384410174626 1.1123099934154572 1.1642979552449093 0.9655714901856381 0.8636017106473424 0.9035081917719309 0.9848359601523271 1.0 10.484385415438688 -6.985515344150947 24.808023163363004 0.9277513422460839 1.0520814509630259 0.3798865585368766 0.07155025213324863 236.87121003759958 405690.155100179 0.027491944068350524 0.024235518154578552 1.0339145708808775e-07 6.985515344150947 0.12433010871694194 QHLENDPGS(ph)NEDTDIPK ddPTM_A459_Selumetinib_30min_R1 1 QHLENDPGSNEDTDIPK 17 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 QHLENDPGS(0.997)NEDT(0.003)DIPK 198.96 6.5746e-08 4418300.0 1073.9 954.57 773.97 875.04 953.66 965.88 983.72 832.31 539.5 743.23 True False 1098.9197805543542 842.8085006324462 668.8691251128924 722.2306905351364 867.4016213823477 956.1641241488718 909.5172084024842 810.2344350760992 915.4920964790139 838.6308101732656 1.3103737272987999 1.0049815609067803 0.7975728019993691 0.8612021902533247 1.0343068855330249 1.1401490531349823 1.0845263462411703 0.9661395995082752 1.0916509212079488 1.0 9.711892023617098 -6.507789127940137 23.916665659963584 1.0595844304290354 0.9762783900542704 0.04094146957748579 0.13343352035784892 1178.7837930867424 1868345.0195423984 0.04480982131341385 0.04910000185137658 3.106067375735325e-07 6.507789127940137 -0.08330604037476497 QHREPS(ph)EQEHR ddPTM_A459_Selumetinib_30min_R2 1 QHREPSEQEHR 11 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 QHREPS(1)EQEHR 64.798 0.035248 748300.0 2332.1 1031.9 795.76 847.74 1131.8 1196.7 2922.1 4405.8 2191.2 2613.2 True False 2202.4912181359805 1111.0434119185386 744.5616679579788 732.2763495669309 989.6131655796227 1361.5345624389997 3057.9834400313043 4418.620148580548 2629.5012272434237 2537.7501260910035 0.867891285076425 0.4378064650635729 0.2933943969908718 0.2885533693953096 0.3899568974128918 0.5365124597732658 1.2049978477359538 1.741156508338637 1.0361545056028618 1.0 11.309334309082915 -7.264649365170134 3.9177410168166533 1.3224474149185772 0.43964898055575247 0.7075958743549757 0.24381529449947703 0.11200281495206114 4.0092003262844775 0.10256862742307217 0.07171683874917613 5.4368911073276235e-08 7.264649365170134 -0.8827984343628248 QHYIDLK ddPTM_A459_Selumetinib_30min_R1 1 QHYIDLK 7 0 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 114.5 0.019228 14376000.0 8518.0 8770.7 9496.2 9905.5 8983.0 8233.7 8736.2 9088.3 5980.9 7392.7 False True 8716.452826857234 7743.822366612192 8206.66819889279 8175.690374263802 8170.489236077466 8150.87645360145 8077.22140044503 8847.248761041095 10149.150472347246 8341.625055995983 1.0449346222522702 0.9283349844459757 0.983821275087618 0.9801076312327289 0.9794841150531569 0.9771329206103045 0.9683030999624109 1.0606145327380387 1.21668744449884 1.0 13.026112751287208 -7.926943581732821 4.401872977434338 1.1176143391374522 0.9787822942726362 0.46998986810722887 0.05565634573797073 0.1494204873404038 5.49086190324392 0.030486696028415586 0.013576024346321885 1.183195252106087e-08 7.926943581732821 -0.13883204486481604 QIANS(ph)QDGYVWQVTDMNR ddPTM_A459_Selumetinib_30min_R2 1 QIANSQDGYVWQVTDMNR 18 0 D6RDN1;D6RE09;P10155-2;P10155-3;P10155-5;P10155-4;P10155 D6RDN1 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 QIANS(1)QDGYVWQVTDMNR 153.11 0.00010389 0.0 4931.9 5848.4 5495.6 6392.5 7645.7 7045.6 3269.3 5140.6 3772.6 4033.1 True False 4657.804741959966 6296.953474430067 5142.019079156863 5521.830472322418 6685.178812574767 8016.067446411143 3421.328927995051 5155.558294927856 4527.225415251248 3916.6539237477496 1.1892306118032065 1.607738032775862 1.3128602065092827 1.4098336436727386 1.7068597181999385 2.0466621770709743 0.8735336321778631 1.3163170388040384 1.1558911007688055 1.0 11.93540594178644 -7.287195812967005 24.99933967179539 1.112795220369194 1.5389475978933678 0.4584117228932971 0.24372856521734737 810.1924248297668 786373.8381670524 0.10563695890736616 0.07124744986143344 5.161835819984722e-08 7.287195812967005 0.4261523775241738 QIASNS(ph)PGSSPK ddPTM_A459_Selumetinib_30min_R1 2 QIASNSPGSSPK 12 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 QIAS(0.018)NS(0.982)PGSSPK;QIAS(0.06)NS(0.818)PGS(0.085)S(0.038)PK 127.32 0.0026635 0.0 2314.41 2085.63 2765.0099999999998 2550.66 2048.65 2040.27 2212.0699999999997 2243.83 1489.72 1877.75 True False 2368.331249942083 1841.4434700169172 2389.536829112755 2105.2351128181012 1863.349969218534 2019.746736216941 2045.211778952225 2184.316339412964 2527.9460351561024 2118.777503333891 1.117781950306495 0.869106580147944 1.1277903533300806 0.9936083942299363 0.8794457965909858 0.953260421652993 0.9652791648646869 1.0309323824592 1.193115384309294 1.0 11.049016380304995 -8.015396929584654 11.13052870071131 1.1017623540303596 0.9834884382645548 0.18691489744644163 0.09100254988747905 0.8354859115749458 590.1507241609097 0.05441682877203145 0.022593048329838557 9.651683464875308e-09 8.015396929584654 -0.11827391576580482 QIASNS(ph)PGSSPK ddPTM_A459_Selumetinib_30min_R2 2 QIASNSPGSSPK 12 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 QIAS(0.052)NS(0.853)PGS(0.094)S(0.001)PK;QIAS(0.191)NS(0.809)PGSSPK 163.62 0.00050249 6675000.0 41205.0 35846.0 44250.0 49421.0 43167.0 35304.0 39036.0 38533.0 36689.0 39832.0 True False 38914.991056684165 38595.27293694345 41403.00317575717 42689.77454401976 37743.97554212368 40166.80554219642 40851.25134836656 38645.12465051847 44027.8251763116 38681.94666403523 1.0060246293877864 0.9977593235458244 1.0703443530222292 1.1036097773153395 0.9757517084117269 1.038386353485714 1.0560805458725337 0.9990480827183653 1.1382008656055236 1.0 15.239372779635183 QICLVMLET(ph)LSQSPQGR ddPTM_A459_Selumetinib_30min_R1 1 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QICLVMLET(0.535)LS(0.317)QS(0.148)PQGR 133.23 0.0065794 17679000.0 1606.3 1525.8 1857.7 1670.5 1750.8 1519.8 1746.1 1739.5 904.85 1547.3 True False 1643.7236646842907 1347.1586266748236 1605.434543615671 1378.7785341686615 1592.4404491288465 1504.5121918679922 1614.390271206824 1693.3628093076804 1535.464362370781 1745.9110269783146 0.9414704640070453 0.771607834453271 0.9195397238507799 0.7897186700028712 0.9120971369800654 0.8617347439931595 0.9246692679413817 0.9699021216667721 0.8794631219142031 1.0 10.769764324610087 -7.2643065190775795 1.3492528145970741 0.9488132028903822 0.8575737864818498 0.2975747132107728 0.058178561019926425 0.5348994399440058 1.8985222049281056 0.0335375607889754 0.0194696060968063 5.4411848593799883e-08 7.2643065190775795 -0.09123941640853239 QICLVMLETLS(ph)QSPQGR ddPTM_A459_Selumetinib_30min_R1 1 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QICLVMLET(0.001)LS(0.692)QS(0.307)PQGR 137.39 0.0019407 20402000.0 1572.7 1571.8 1696.9 1457.8 1722.7 1534.3 1280.9 1526.2 957.47 1292.2 True False 1609.3408500585085 1387.7729252900049 1466.470300404496 1203.2225962951659 1566.8820891673886 1518.8663350329382 1184.280681741494 1485.7202182037252 1624.7566591580394 1458.0664570938916 1.103749998656526 0.9517898985592258 1.0057636901731861 0.8252179387579759 1.0746300907918698 1.0416989758205044 0.8122268199639632 1.0189660498499848 1.114322774008794 1.0 10.509840762306885 -7.9972639143343045 24.999634378307665 1.060322428475029 0.9705544954153685 0.11497938275853381 0.09379302022501629 156.0372301765839 1425717.5205165022 0.05097916955422893 0.024264654759593527 1.0063199572500231e-08 7.9972639143343045 -0.08976793305966047 QICLVMLETLS(ph)QSPQGR ddPTM_A459_Selumetinib_30min_R2 2 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QICLVMLETLS(0.653)QS(0.347)PQGR;QICLVMLET(0.142)LS(0.692)QS(0.166)PQGR 134.08 0.0049878 12803000.0 67818.0 56338.6 72518.8 78770.0 77699.0 62913.2 58668.1 55427.0 58823.0 64948.3 True False 64048.94705696402 60659.589462848926 67853.01936049935 68041.39011417095 67937.75698212672 71578.92223083247 61396.282898634694 55588.28339356621 70589.24365194414 63073.07382305081 1.0154721052069062 0.9617351079642508 1.0757842490895324 1.078770796949877 1.0771277323937567 1.134857045839315 0.973415106910434 0.881331446593472 1.1191660620501813 1.0 15.944736623226428 -9.934127011154484 6.012287553501433 1.000000001272661 1.0334117776953007 0.019215827909960792 0.07456292365096338 13906018.124576759 22976968.041250307 0.07548317452656449 0.01887079363261381 1.1637856258858228e-10 9.934127011154484 0.033411776422639594 QICLVMLETLSQS(ph)PQGR ddPTM_A459_Selumetinib_30min_R1 7 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QICLVMLETLS(0.008)QS(0.992)PQGR;QICLVMLETLS(0.001)QS(0.999)PQGR;QICLVMLETLS(0.009)QS(0.991)PQGR;QICLVMLET(0.005)LS(0.035)QS(0.96)PQGR;QICLVMLETLS(0.234)QS(0.766)PQGR;QICLVMLETLS(0.389)QS(0.611)PQGR;QICLVMLETLSQS(1)PQGR 232.6 8.534799999999999e-17 1305924400.0 14118.71 14323.84 16995.61 16091.239999999998 17768.840000000004 13334.240000000002 15294.679999999998 15808.2 9353.939999999999 12298.37 True False 14447.648472772658 12646.798153827445 14687.699512203224 13281.207003984513 16161.651559343502 13200.10965212124 14140.989973782485 15388.915183729612 15872.952995252854 13876.9855857683 1.0411229718066155 0.9113505289504309 1.0584214721146905 0.9570671470326528 1.164637050276846 0.9512231291541272 1.01902462075661 1.1089523073016585 1.1438329237389668 1.0 13.760406593519683 -6.051998770332555 0.6672584914159828 1.0706744756774365 0.9746848550027682 0.11829772721214615 0.07544929255078217 1.9451859741301318 1.7075947576716342 0.045620040429245626 0.11288692174540257 8.871585239474055e-07 6.051998770332555 -0.09598962067466821 QICLVMLETLSQS(ph)PQGR ddPTM_A459_Selumetinib_30min_R2 5 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QICLVMLET(0.058)LS(0.096)QS(0.846)PQGR;QICLVMLETLS(0.082)QS(0.917)PQGR;QICLVMLET(0.011)LS(0.011)QS(0.978)PQGR;QICLVMLET(0.004)LS(0.162)QS(0.835)PQGR;QICLVMLETLS(0.012)QS(0.988)PQGR 186.17 5.9481e-08 677213600.0 782668.5 625048.7 729836.2 861074.5 896264.1 733813.0 813456.1 876708.5 644245.4 873503.9 True False 739170.9180402478 672987.9254416572 682879.333477572 743794.6676636369 783667.3910552852 834889.0798588208 851283.4204826826 879259.5765880956 773112.4817204879 848283.5727713064 0.8713724298885192 0.7933525380469578 0.8050130350239297 0.8768231420934998 0.9238271448485996 0.9842098876573474 1.0035363736934995 1.0365160953377794 0.9113844786534794 1.0 19.69418709847379 -6.330893605205133 1.634176489426906 0.9915540279784382 0.8208920405518833 0.7968572899377329 0.03624054577510041 0.15468437013759248 0.8214101162662198 0.01321144843561449 0.016839959803630785 4.6677371796610717e-07 6.330893605205133 -0.17066198742655492 QICVVMLETLS(ph)QSPPK ddPTM_A459_Selumetinib_30min_R1 1 QICVVMLETLSQSPPK 16 0 H3BRU6;F8VZX2;Q15366;Q15366-2;Q15366-5;Q15366-8 H3BRU6;Q15366;Q15366-5 PCBP2 Poly(rC)-binding protein 2 1 QICVVMLET(0.018)LS(0.587)QS(0.394)PPK 94.882 0.016671000000000002 0.0 1346.3 1259.3 964.82 1083.0 1077.0 1075.2 1388.3 1187.7 551.36 853.87 True False 1377.6661705562212 1111.8605705673135 833.8027433769015 893.8743804278122 979.5855401597936 1064.3844642034903 1283.579413273258 1156.1983378066864 935.6176502588862 963.4725318981278 1.4298966757693596 1.1540137718060812 0.8654141304207551 0.9277632219226831 1.0167238896057802 1.104737736639525 1.3322428722949586 1.2000324861663376 0.971089075487845 1.0 9.912099726395112 -7.002504674117826 24.425176380260528 1.1533647300591958 1.062504375848501 0.0020292213636216028 0.17127962278831482 265.4020267748264 2588195.4390059104 0.06507482365786238 0.056389791686168166 9.942493732327763e-08 7.002504674117826 -0.09086035421069472 QICVVMLETLS(ph)QSPPK ddPTM_A459_Selumetinib_30min_R2 1 QICVVMLETLSQSPPK 16 0 H3BRU6;F8VZX2;Q15366;Q15366-2;Q15366-5;Q15366-8 H3BRU6;Q15366;Q15366-5 PCBP2 Poly(rC)-binding protein 2 1 QICVVMLET(0.021)LS(0.626)QS(0.353)PPK 108.77 0.011711 9275700.0 42752.0 29805.0 32824.0 35364.0 34937.0 31901.0 47390.0 40168.0 30618.0 27846.0 True False 40376.0149898158 32090.947661820013 30712.139576069025 30547.362193697318 30547.901719257174 36295.0731815547 49593.72890150354 40284.88222982963 36742.45553839867 27042.013627403205 1.493084632902503 1.1867070294388298 1.1357194031196949 1.1296260187792355 1.1296459701618247 1.3421734668743324 1.8339510357781716 1.4897145894862902 1.3587174403745386 1.0 14.72291496246048 -7.000344863081451 23.694506039856254 1.4794991290071025 1.2074109603858387 0.14707667554950776 0.2166849812588989 8.870722017342015 609568.5430574041 0.07546874262856591 0.06574934481988658 9.992062386049077e-08 7.000344863081451 -0.2720881686212637 QICVVMLETLSQS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 4 QICVVMLETLSQSPPK 16 0 H3BRU6;F8VZX2;Q15366;Q15366-2;Q15366-5;Q15366-8 H3BRU6;Q15366;Q15366-5 PCBP2 Poly(rC)-binding protein 2 1 QICVVMLET(0.007)LS(0.353)QS(0.64)PPK;QICVVMLET(0.238)LS(0.081)QS(0.68)PPK;QICVVMLETLSQS(1)PPK;QICVVMLETLS(0.004)QS(0.996)PPK 278.27 1.8813999999999997e-62 317679700.0 15407.5 18288.4 13075.900000000001 11910.1 11812.8 12663.599999999999 12574.099999999999 13874.099999999999 10357.61 14201.8 True False 15766.464772223864 16147.185625953507 11300.264600777375 9830.2246152662 10744.334325719225 12536.215681628832 11625.62551353401 13506.113798571821 17576.107680096404 16024.739367246588 0.9838827584584234 1.0076410764568933 0.7051761867574771 0.6134405302939572 0.6704841857010087 0.7823038736749723 0.7254798500683232 0.8428289215222647 1.0968108296363748 1.0 13.96801327201664 -8.138498308220097 4.304209636738841 1.045793156486384 0.7789494661219546 0.4224706303829826 0.12134839526728233 0.2424450740456883 7.104161056596703 0.10179937805144988 0.03542335158362735 7.269452309998972e-09 8.138498308220097 -0.26684369036442945 QICVVMLETLSQS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 3 QICVVMLETLSQSPPK 16 0 H3BRU6;F8VZX2;Q15366;Q15366-2;Q15366-5;Q15366-8 H3BRU6;Q15366;Q15366-5 PCBP2 Poly(rC)-binding protein 2 1 QICVVMLETLS(0.019)QS(0.981)PPK;QICVVMLETLS(0.003)QS(0.997)PPK;QICVVMLETLS(0.009)QS(0.991)PPK 220.64 7.896500000000001e-11 145678000.0 160804.0 108313.0 104056.1 133808.0 123803.0 125900.0 173818.0 161147.0 129190.0 108551.7 True False 151867.1574294148 116620.25881881242 97361.2438137156 115583.11956832519 108249.76032713719 143241.5821935908 181900.88141383274 161615.91109067813 155031.60987019818 105417.5303698121 1.4406252631479237 1.1062700711134132 0.9235773544700348 1.0964316766182198 1.0268667834219738 1.3588022949417355 1.725527820427131 1.5331028010589716 1.4706435383786398 1.0 16.685755273808518 -6.917153496637739 4.9738641579223275 1.4852739760090348 1.1080154573107706 0.3236060828651689 0.21175153054220625 0.205126067355956 8.913248323621323 0.07477957276001759 0.06549676847152786 1.2101703364767124e-07 6.917153496637739 -0.3772585186982642 QIDSS(ph)PVGGETDETTVSQNYR ddPTM_A459_Selumetinib_30min_R2 2 QIDSSPVGGETDETTVSQNYR 21 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0 O15027 SEC16A Protein transport protein Sec16A 1 QIDS(0.235)S(0.765)PVGGETDETTVSQNYR;QIDS(0.235)S(0.765)PVGGETDETTVSQNYR 190.1 1.5214000000000002e-16 160016000.0 132983.0 120381.0 135006.0 153234.0 169515.0 112947.0 117169.0 125252.0 108610.0 137614.0 True False 125592.33723312758 129613.83561407687 126319.86094341845 132363.26485660602 148219.01021667232 128504.42401921743 122617.59066596896 125616.46258341511 130335.03481695338 133640.72625588853 0.9397759257357648 0.9698677884008116 0.9452198029928957 0.9904410770947437 1.1090856385565433 0.9615663399880335 0.9175166440744043 0.9399564496745628 0.9752643409569208 1.0 17.02800020241181 -5.763184490491209 24.980861554810858 0.9837340241711411 0.9534458316653759 0.08938095225957943 0.048385089124565316 144.5382822848215 2069088.8875695567 0.015078377654138973 0.023726818659744523 1.725104903029552e-06 5.763184490491209 -0.0302881925057652 QIFEDHVFCHS(ph)L ddPTM_A459_Selumetinib_30min_R1 1 QIFEDHVFCHSL 12 0 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 QIFEDHVFCHS(1)L 132.51 0.0012392999999999998 2143200.0 1603.5 1665.8 2001.0 1993.8 2184.4 1432.4 1649.9 1592.9 923.86 1523.9 True False 1640.8584301321423 1470.7673615905894 1729.2751907062257 1645.6202582612852 1986.8214056871436 1417.991356515142 1525.4467146578897 1550.6511175315916 1567.7229439353148 1719.5074090430137 0.9542607502024995 0.8553422647996267 1.0056805696863198 0.9570300480282024 1.1554596364274479 0.8246497508866917 0.8871416933916395 0.9017996138758143 0.9117279377166662 1.0 10.747779616849318 QIFEDHVFCHS(ph)L ddPTM_A459_Selumetinib_30min_R2 2 QIFEDHVFCHSL 12 0 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 QIFEDHVFCHS(1)L;QIFEDHVFCHS(1)L 130.47 0.0015997 1706400.0 20355.4 18485.6 18856.7 22019.0 22328.7 17226.5 21723.0 21420.6 16610.7 19830.6 True False 19224.12835712241 19903.386079427604 17643.48045162261 19019.974215106355 19523.56908488931 19599.294008402623 22733.162543307895 21482.930399628764 19933.30414173618 19258.03905191345 0.9982391408232361 1.0335105264754376 0.9161618378725627 0.9876381579575496 1.0137880098934309 1.0177201300490284 1.1804505371510898 1.1155305242510791 1.0350640627533485 1.0 14.233173187917275 -7.033273468512445 13.466492467722873 1.093355963945531 0.9908354517655218 0.4012546874215842 0.05308449120070738 2.4779536463388707 1001.7485054738324 0.020229418828736547 0.015780713050383723 9.26246396693399e-08 7.033273468512445 -0.10252051218000924 QILIACS(ph)PVSSVR ddPTM_A459_Selumetinib_30min_R1 2 QILIACSPVSSVR 13 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 QILIACS(0.996)PVS(0.004)SVR;QILIACS(0.996)PVS(0.004)SVR 203.11 6.3399e-05 273000000.0 6606.8 7212.200000000001 7357.7 6973.1 8045.0 6382.1 6860.7 7275.5 4335.3 6333.799999999999 True False 6760.725585405073 6367.792271139187 6358.5647529531225 5755.378986298414 7317.331170460107 6317.90186848316 6343.191875418741 7082.5301058453715 7356.687462215888 7146.804926436538 0.9459787492445287 0.8909984722801474 0.889707333333297 0.8053079726590632 1.023860486718027 0.8840176741235504 0.8875563193217747 0.9910064957344212 1.0293673239915895 1.0 12.803082694804239 -7.847564533533553 4.741755290679575 1.0127399592832673 0.9029710377243103 0.44970581844064317 0.05242342235138792 0.19330449952280096 7.569844516936589 0.029879864979602433 0.013927670450452607 1.4204811222729717e-08 7.847564533533553 -0.10976892155895701 QILIACS(ph)PVSSVR ddPTM_A459_Selumetinib_30min_R2 4 QILIACSPVSSVR 13 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 QILIACS(0.871)PVS(0.114)S(0.016)VR;QILIACS(0.996)PVS(0.004)SVR;QILIACS(0.998)PVS(0.002)SVR;QILIACS(0.994)PVS(0.005)S(0.001)VR 179.79 0.00011046 298305000.0 307317.0 292917.0 321642.0 372608.0 341164.0 288854.0 276472.0 308634.0 289616.0 295061.0 True False 290237.5514274236 315382.79202339606 300947.90389733075 321858.1476153478 298303.92827514233 328641.0165444597 289328.49581887515 309532.073842891 347547.2925471578 286541.82226945425 1.0128976954522682 1.1006518682875575 1.0502756683606538 1.1232501596666866 1.0410484791104155 1.1469216393668942 1.0097251895983281 1.0802334939847542 1.212902499867318 1.0 18.128386197632928 -4.754169142154248 24.624673190584407 1.0858275513529232 1.0128975400413935 0.10960910855525574 0.0616109383440333 474.7140897331687 1607710.9405634336 0.014402665861153284 0.14185946779556557 1.7612899534280668e-05 4.754169142154248 -0.07293001131152965 QILIACSPVS(ph)SVR ddPTM_A459_Selumetinib_30min_R2 2 QILIACSPVSSVR 13 0 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 QILIACS(0.204)PVS(0.614)S(0.182)VR;QILIACS(0.283)PVS(0.559)S(0.158)VR 101.61 0.0099769 5138500.0 88188.0 100883.0 100313.0 110095.0 110766.0 77796.0 79119.0 80278.0 68104.0 94605.0 True False 83286.864004535 108620.40171002799 93858.9707925365 95099.87107553173 96850.58481939595 88511.69283822538 82798.19027132436 80511.59568926167 81726.70298475093 91873.50783669029 0.906538413147145 1.182282077474457 1.0216108321386341 1.0351174491407955 1.054173146317137 0.9634082220476364 0.9012194289838399 0.8763309204692066 0.8895567929116649 1.0 16.487361293048792 -6.945648860115438 2.901640703506492 0.9071763621559755 1.047008356882209 0.40462643660914555 0.07000081322619449 0.23261065279792065 3.9833593542807537 0.02615388942480307 0.021870171245507396 1.1333163125300907e-07 6.945648860115438 0.13983199472623353 QIPS(ph)AEDLETDGGGPGQVVDDGLEHR ddPTM_A459_Selumetinib_30min_R1 1 QIPSAEDLETDGGGPGQVVDDGLEHR 26 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 QIPS(1)AEDLETDGGGPGQVVDDGLEHR 129.33 4.1851e-09 1761000.0 342.93 333.98 237.91 321.29 306.48 216.3 263.39 159.43 212.4 278.97 True False 350.9196017743779 294.87746633691035 205.603128746086 265.182732860251 278.75893811343894 214.12421838468657 243.5222802434945 155.2013984983751 360.4272869177806 314.77851689791277 1.1148143311450514 0.9367776087227179 0.6531676010557166 0.8424422844150244 0.8855716738885472 0.6802377128364517 0.7736305598087315 0.49304952583123446 1.1450186959063422 1.0 8.298193272480196 -4.954292246418035 3.8040632391800537 0.7886878550148673 1.1038635640431722 0.22152260395365841 0.17407817746218293 0.29729631542465346 8.733063446171128 0.04169615130295997 0.20197851025255986 1.1109838699242573e-05 4.954292246418035 0.31517570902830494 QIS(ph)LPDLSQEEPQLK ddPTM_A459_Selumetinib_30min_R1 1 QISLPDLSQEEPQLK 15 0 H0YBZ4;Q15390-2;Q15390 H0YBZ4 MTFR1 Mitochondrial fission regulator 1 1 QIS(0.962)LPDLS(0.038)QEEPQLK 195.6 3.3838000000000004e-05 2470900.0 1608.5 1448.8 1648.7 1875.9 1876.8 1423.9 1652.4 1380.3 944.92 1383.6 True False 1645.9749204038358 1279.1738224711537 1424.8155956608475 1548.3092800041873 1707.0437713759518 1409.5768587977589 1527.7581376451276 1343.689960153717 1603.460225773773 1561.1985374052842 1.0543021153090817 0.8193537156376944 0.9126421537832686 0.991743998541967 1.0934187615964992 0.9028812319671263 0.9785803029153904 0.8606784646281651 1.027070028158448 1.0 10.608438300976434 -5.754240941355156 24.88625933868441 0.9749448810979939 0.9178247502850669 0.07023015831696189 0.0801721510473745 396.6719989851462 1371348.2228368244 0.021672449034869125 0.036552977587770964 1.760998794401848e-06 5.754240941355156 -0.057120130812926995 QIS(ph)LPDLSQEEPQLK ddPTM_A459_Selumetinib_30min_R2 2 QISLPDLSQEEPQLK 15 0 H0YBZ4;Q15390-2;Q15390 H0YBZ4 MTFR1 Mitochondrial fission regulator 1 1 QIS(1)LPDLSQEEPQLK;QIS(1)LPDLSQEEPQLK 142.4 0.00038158 3239600.0 25435.0 17957.9 19932.2 23615.0 24215.4 14823.1 18571.4 19056.3 16724.6 16907.1 True False 24021.424524372305 19335.213186250552 18649.783952538473 20398.596261852785 21173.2449635773 16864.8474742956 19435.006898530963 19111.75067805971 20069.987324368096 16418.948093078678 1.4630306636086152 1.1776158299934703 1.1358695969323511 1.2423814330987322 1.289561599412253 1.0271576095307158 1.1836937901474753 1.164005791949374 1.2223674263778503 1.0 14.003074080994583 -4.761821865271783 6.216339154921364 1.1672036180952325 1.4726949129652978 0.5312333495730419 0.08514745376002533 0.10036286906162528 16.3069881802136 0.02048101343131185 0.13041649913206987 1.7305260241625536e-05 4.761821865271783 0.3054912948700652 QIS(ph)QDVK ddPTM_A459_Selumetinib_30min_R1 1 QISQDVK 7 0 E9PIJ1;E9PJF6;A0A590UK85;A0A590UJY6;A0A5F9UK94;H0Y360;Q01433-3;Q01433-5;Q01433-2;Q01433-4;Q01433 E9PIJ1 AMPD2 AMP deaminase 2 1 QIS(1)QDVK 88.596 0.032069 17241000.0 6532.3 6834.6 5637.2 6685.3 5722.2 6214.2 5930.3 5477.8 2374.5 5107.9 True False 6684.489880356837 6034.401854680663 4871.699202923108 5517.837853623322 5204.628020336467 6151.690790042162 5482.972696488077 5332.510949597938 4029.3530733816838 5763.548720159334 1.1597871736515906 1.0469941606590325 0.8452603490421139 0.957368128827196 0.9030249023717083 1.0673442853922988 0.9513188770852448 0.9252131297070947 0.6991097445377874 1.0 12.49274166308312 -5.00348966019399 3.8642617031212154 0.9234339838471743 1.147924449884984 0.4115715058599212 0.09274330878500617 0.21084890943012527 7.015874723057424 0.024013120309342786 0.09813362169409293 9.919969567023962e-06 5.00348966019399 0.22449046603780975 QIS(ph)QDVK ddPTM_A459_Selumetinib_30min_R2 2 QISQDVK 7 0 E9PIJ1;E9PJF6;A0A590UK85;A0A590UJY6;A0A5F9UK94;H0Y360;Q01433-3;Q01433-5;Q01433-2;Q01433-4;Q01433 E9PIJ1 AMPD2 AMP deaminase 2 1 QIS(1)QDVK;QIS(1)QDVK 102.52 0.019224 59904000.0 377720.0 408630.0 396100.0 336030.0 361360.0 226170.0 319180.0 309430.0 262440.0 344990.0 True False 356727.8345329628 439970.60704745905 370615.3572410717 290262.1343159178 315962.7262006119 257322.8645331567 334022.5024431718 310330.39007110556 314935.3331862743 335029.24230833206 1.0647662636106887 1.313230463156252 1.106217936940529 0.8663785056970804 0.9430899942454188 0.7680609094305234 0.9969950686745316 0.9262785180569527 0.9400234171094681 1.0 18.353927498043127 -5.619320867411343 4.546626436462733 0.9155825963971187 1.1939204268157126 0.6388777673016661 0.0843363147750121 0.11454442285689798 4.119878865781112 0.022113122775905006 0.03971541505564716 2.402587053882838e-06 5.619320867411343 0.27833783041859395 QISGQYS(ph)GSPQLLK ddPTM_A459_Selumetinib_30min_R1 1 QISGQYSGSPQLLK 14 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 QIS(0.022)GQYS(0.489)GS(0.489)PQLLK 120.54 0.0020512 9583600.0 1180.1 1342.6 1533.8 1289.9 1396.3 1556.8 929.82 1126.4 810.29 1381.5 True False 1207.594033925127 1185.4077678421938 1325.5183845603242 1064.6431794218245 1270.0049115367876 1541.1400054613032 859.6829287976236 1096.5242129371488 1375.002948759927 1558.828981949553 0.7746802554407519 0.7604476062278884 0.8503295742567999 0.6829762544511625 0.8147172821668052 0.9886523943979235 0.5514927799985212 0.7034281666778983 0.8820742779880038 1.0 10.606246944303361 -8.523856046565474 4.654601010443954 0.999713030419039 0.768256504378302 0.3249235367237072 0.10777142099489291 0.19167992680355497 14.806968559161108 0.105452030789845 0.02748664011456223 2.9932566320998155e-09 8.523856046565474 -0.23145652604073708 QISGQYSGS(ph)PQLLK ddPTM_A459_Selumetinib_30min_R2 2 QISGQYSGSPQLLK 14 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 QISGQYS(0.003)GS(0.997)PQLLK;QISGQYS(0.004)GS(0.996)PQLLK 187.56 8.869200000000001e-05 15266600.0 69645.0 53661.0 62884.0 82765.0 81831.0 62510.0 68092.0 67086.0 58070.0 53799.0 True False 65774.4097110245 57776.626152689874 58838.111902922385 71492.26422241131 71550.65820157804 71120.18509071764 71258.41292173824 67281.2091533149 69685.62261136623 52245.6830834111 1.2589443917503111 1.105864116283991 1.1261813116499282 1.3683860560933372 1.3695037365545826 1.3612643359868237 1.363910063305575 1.2877850414147967 1.3338063261631008 1.0 15.673024215758307 -5.757411591249529 24.998183651372596 1.3181845814859978 1.157883331455821 0.2170954723660362 0.11199754909643837 121.60698462263846 754731.7447022034 0.028710063199704754 0.0474940862366564 1.748189102730189e-06 5.757411591249529 -0.1603012500301768 QISLAPETLDSSGDVS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 1 QISLAPETLDSSGDVSPGPR 20 0 Q8TER5;Q8TER5-2 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 QISLAPET(0.004)LDS(0.331)S(0.019)GDVS(0.646)PGPR 158.44 2.0771e-07 0.0 10551.0 8034.9 8465.1 9491.4 10498.0 7224.9 6950.9 7737.3 7146.9 7004.4 True False 9964.617658999494 8651.150993724461 7920.464682104005 8198.654946421748 9179.14738668923 8220.064393887795 7274.130622947052 7759.81426202103 8576.479701070653 6802.164772383218 1.4649185946591343 1.2718232038200727 1.164403531396517 1.2053008447705176 1.3494450213785703 1.208448290941326 1.0693846542030288 1.1407859882380191 1.2608456260705638 1.0 12.731778238285166 -1.5228787452803376 0.10957802496639943 0.9510490614584577 2.1755354230915107 0.5191367230284836 0.08811846194491336 102.19724019693929 0.7853065351394247 0.8802057890747094 18.910522253468503 0.029999999999999995 1.5228787452803376 1.224486361633053 QIT(ph)MEELVR ddPTM_A459_Selumetinib_30min_R1 3 QITMEELVR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 QIT(1)MEELVR;QIT(1)MEELVR;QIT(1)MEELVR 114.24 0.020231 33821500.0 6119.5 5299.5 5147.44 7197.7 5368.8 6845.3 6233.200000000001 4294.97 2722.71 4278.3099999999995 True False 6262.072443525812 4679.032076329289 4448.445920863996 5940.75681256257 4883.192987938625 6776.442497035114 5763.024705621893 4181.0534435712625 4620.240011129522 4827.472762768431 1.2971740600634016 0.9692508495161318 0.9214854520096615 1.2306142581228567 1.0115423178769507 1.4037246464232767 1.1937974565219396 0.866095708673359 0.9570722069656865 1.0 12.237052403987207 -7.759238430555706 24.999983341548806 0.933687950903522 1.1392071106483757 0.2977126408792501 0.14434593299503284 76.54634318758487 869502.1545822495 0.07460045190301001 0.040371707285051954 1.7408508722962962e-08 7.759238430555706 0.20551915974485369 QIT(ph)MEELVR ddPTM_A459_Selumetinib_30min_R2 3 QITMEELVR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 QIT(1)MEELVR;QIT(1)MEELVR;QIT(1)MEELVR 112.64 0.02239 29334200.0 35020.6 37039.2 39442.0 44499.0 34076.0 24962.5 33030.2 28521.7 34843.6 24262.3 True False 33074.29525056942 39879.987540200724 36904.3446612026 38438.159434943336 29795.068236694842 28400.857787986562 34566.16974809964 28604.6934249784 41813.29361152745 23561.78435797403 1.4037262521408345 1.6925707719884175 1.5662797053277098 1.631377269690302 1.2645505868324136 1.2053780544161055 1.4670438037686813 1.2140291664836367 1.7746233891397343 1.0 14.5241611796228 -6.258802952820451 24.877007829901647 1.3331662994851967 1.5814794687847873 0.27245030648289503 0.20141928025132042 298.56865032283775 2817257.843656858 0.0575174950321759 0.0708667753831544 5.510576644189467e-07 6.258802952820451 0.24831316929959057 QIT(ph)SPVSGINGDIR ddPTM_A459_Selumetinib_30min_R1 2 QITSPVSGINGDIR 14 0 A0A087WXV4;P41235-7;P41235-3;P41235-6;P41235-5;P41235-2;P41235;P41235-4 A0A087WXV4 HNF4A Hepatocyte nuclear factor 4-alpha 1 QIT(0.877)S(0.119)PVS(0.004)GINGDIR;QIT(0.498)S(0.498)PVS(0.003)GINGDIR 150.37 0.00098757 45085000.0 4089.7999999999997 4694.200000000001 5340.7 6127.3 6042.799999999999 4433.0 4953.8 5529.5 3092.5 4884.700000000001 True False 4185.084382634506 4144.600881725624 4615.462274365186 5057.282078666055 5496.2298069429935 4388.408044841955 4580.13087767274 5382.83969765267 5247.746632736519 5511.698826007223 0.7593093372386348 0.7519643239882993 0.8373937727850621 0.9175541404408782 0.9971934208394627 0.7961988097272361 0.8309835174703608 0.9766207965234739 0.9521105558189732 1.0 12.428281342135207 -2.343930123509671 0.2455527642109395 0.9708630668998305 5.444446438645533e-15 0.5310148404315006 0.06359759127164565 31.180376784364977 0.5996911851163451 0.09501497264714492 11.446185563572502 0.0045297045543107005 2.343930123509671 -0.970863066899825 QIT(ph)SPVSGINGDIR ddPTM_A459_Selumetinib_30min_R2 4 QITSPVSGINGDIR 14 0 A0A087WXV4;P41235-7;P41235-3;P41235-6;P41235-5;P41235-2;P41235;P41235-4 A0A087WXV4 HNF4A Hepatocyte nuclear factor 4-alpha 1 QIT(0.878)S(0.094)PVS(0.028)GINGDIR;QIT(0.971)S(0.029)PVSGINGDIR;QIT(0.477)S(0.477)PVS(0.046)GINGDIR;QIT(0.801)S(0.121)PVS(0.078)GINGDIR 218.34 2.4816e-08 98781600.0 356237.0 311342.0 377852.0 413916.0 430667.0 293011.0 348435.0 400965.0 299963.0 325071.0 True False 336438.77366969996 335220.93027768336 353541.41369415174 357539.92675507336 376562.7612481703 333370.60556097113 364637.91791085433 402131.74176667054 359963.98166649346 315685.35559411003 1.0657408324707767 1.0618830564592012 1.1199170548434145 1.13258318898637 1.1928420326609412 1.0560217623449082 1.1550675742453023 1.2738371756582472 1.1402618945977157 1.0 18.268127811103582 -5.419036638611802 2.138884914599354 1.1473820156906427 1.0603087737675456 0.12783848818274623 0.06962691502245014 0.5841083000734986 5.094931022088817 0.01986411675944269 0.05719270806024706 3.810336766950639e-06 5.419036638611802 -0.08707324192309707 QITQEEDDS(ph)DEEVAPENFFSLPEK ddPTM_A459_Selumetinib_30min_R1 2 QITQEEDDSDEEVAPENFFSLPEK 24 0 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 QITQEEDDS(0.999)DEEVAPENFFSLPEK;QIT(0.002)QEEDDS(0.997)DEEVAPENFFSLPEK 122.77 9.8619e-08 10175300.0 4836.9 4874.0 4569.5 4600.1 5592.1 4545.9 5893.5 5363.6 3054.1 5023.5 True False 4949.590359030966 4303.349814138875 3948.986998466815 3796.7788895715435 5086.295542365444 4500.172373346955 5448.948550115927 5221.339904571817 5182.58463736155 5668.315158033716 0.8732030984579078 0.7591938158272177 0.6966773879659649 0.6698249451056651 0.8973205265689268 0.7939171072675538 0.9612995040321849 0.921144953835462 0.9143077780381109 1.0 12.468704258918741 -6.943896445674171 1.2870989677108637 0.9473565499088258 0.754408666969059 0.5878949445656847 0.06860414985957829 0.3256727169275368 1.1121828704227772 0.03751321489547298 0.028649317032816157 1.1378985770271377e-07 6.943896445674171 -0.19294788293976683 QITQEEDDS(ph)DEEVAPENFFSLPEK ddPTM_A459_Selumetinib_30min_R2 1 QITQEEDDSDEEVAPENFFSLPEK 24 0 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 QIT(0.001)QEEDDS(0.999)DEEVAPENFFSLPEK 103.68 1.0975e-06 1562300.0 4332.6 4261.2 4546.6 6690.6 7320.4 3605.8 4446.2 4977.0 4890.5 5632.7 True False 4091.8114367719863 4588.020338082447 4254.076705963789 5779.328738071234 6400.74590679366 4102.466219806587 4652.95710997816 4991.482246013297 5868.73665198702 5470.069315487832 0.7480364874328965 0.8387499451043571 0.77770069456321 1.056536655158605 1.1701398168156172 0.7499843207088722 0.8506212337755723 0.9125080429749813 1.072881587692209 1.0 12.417343399302762 -5.744246839973672 24.881704982142498 0.9633861836307763 0.7932210482359864 0.3538788724233789 0.1139974565233052 304.23898917590225 440302.6273752492 0.0333806612402229 0.057633342651517934 1.8019932507596663e-06 5.744246839973672 -0.17016513539478995 QITT(ph)SPITVR ddPTM_A459_Selumetinib_30min_R1 3 QITTSPITVR 10 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 QIT(0.061)T(0.727)S(0.211)PITVR;QIT(0.012)T(0.493)S(0.493)PIT(0.002)VR;QIT(0.004)T(0.498)S(0.498)PITVR 147.58 0.0019162 56256000.0 11672.3 13442.300000000001 12483.0 13219.2 13256.099999999999 12451.2 12461.4 13089.6 6925.800000000001 10863.3 True False 11944.241879657864 11868.469266844273 10787.877164210802 10910.714875116657 12057.088095554544 12325.952232785066 11521.426565269297 12742.421286986948 11752.576759581763 12257.710372502761 0.9744268314947229 0.9682452029106792 0.8800890897545453 0.8901103504282687 0.9836329729736261 1.005567259970132 0.9399330066661438 1.0395433486152128 0.958790541008854 1.0 13.581401901586021 -6.369758827561496 7.584882450630524 0.9887883383207124 0.9277617791557324 0.3831921703264808 0.0371289530099239 0.30556805039772056 19.07130815523518 0.011968258582389023 0.013570137772478773 4.26816472752863e-07 6.369758827561496 -0.06102655916498001 QITTS(ph)PITVR ddPTM_A459_Selumetinib_30min_R2 4 QITTSPITVR 10 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 QIT(0.059)T(0.093)S(0.847)PITVR;QIT(0.031)T(0.104)S(0.856)PIT(0.009)VR;QIT(0.054)T(0.095)S(0.811)PIT(0.04)VR;QIT(0.023)T(0.106)S(0.857)PIT(0.014)VR 123.26 0.00421 93069300.0 332519.0 294637.0 368507.0 369081.0 383519.0 285772.0 316690.0 321554.0 284359.0 291287.0 True False 314038.9251590233 317234.71049272426 344797.66082008486 318811.53109976236 335337.9145166387 325134.4990200702 331416.7125093303 322489.66890386946 341238.74565430486 282876.7874554835 1.1101615229154984 1.1214589692787984 1.2188969760353556 1.127033200452808 1.1854557510110688 1.1493855750579633 1.171593878347072 1.1400358149026981 1.206315826490379 1.0 18.109814270128766 -10.906556630572942 6.354700940844624 0.9999807375128319 1.1589668443694188 0.655374981714499 0.03457367967059029 9.051151858824701e-06 8.77873101848496e-07 0.032109242868267635 0.007786692233301135 1.2400619145781995e-11 10.906556630572942 0.15898610685658687 QIVGTPVNS(ph)EDSDTR ddPTM_A459_Selumetinib_30min_R2 4 QIVGTPVNSEDSDTR 15 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 QIVGT(0.164)PVNS(0.779)EDS(0.056)DTR;QIVGT(0.11)PVNS(0.866)EDS(0.023)DTR;QIVGT(0.465)PVNS(0.522)EDS(0.01)DT(0.003)R;QIVGT(0.131)PVNS(0.863)EDS(0.006)DTR 191.41 2.8644e-05 42062900.0 106746.4 95381.8 113092.4 126711.0 128938.0 88302.3 105598.9 95143.2 98163.1 114617.1 True False 100813.86242769637 102697.27735917382 105816.15810969514 109452.74321133281 112739.65571965498 100465.14029652982 110509.45809025057 95420.05096019535 117798.46290617864 111307.80651201044 0.905721400743067 0.9226421809695126 0.9506625045052637 0.9833339335415126 1.0128638704913302 0.9025884476996618 0.9928275612755542 0.8572628816461246 1.0583126790255077 1.0 16.764195253291106 -5.2605068701652495 2.5799492080405693 0.966098718110947 0.9091330869234335 0.15101763753720154 0.05368151930583261 0.59194775356529 7.5713719505199855 0.013892039297852515 0.04523264737758635 5.488998724143875e-06 5.2605068701652495 -0.05696563118751352 QKDFLDGVYAFEYYPS(ph)TPGR ddPTM_A459_Selumetinib_30min_R1 1 QKDFLDGVYAFEYYPSTPGR 20 1 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 QKDFLDGVYAFEYYPS(0.5)T(0.5)PGR 207.24 6.6274e-17 65694000.0 5864.2 5790.8 6983.1 6687.6 7129.6 5499.3 6102.9 6416.2 3657.2 5192.1 True False 6000.824450253137 5112.810443930116 6034.83337542261 5519.73620179967 6484.728938833117 5443.982034964894 5642.553339527024 6246.021533245148 6206.001288680358 5858.556610336788 1.0242837697710956 0.8727082085217229 1.0300887704617891 0.9421665725753496 1.1068816724227801 0.9292360554064764 0.9631302921220135 1.0661365842611676 1.0593055084132057 1.0 12.516329552106873 -6.034679130512166 0.5111361306648539 1.0278313090005513 0.9473411247512726 0.08678354830375345 0.06531955333158014 3.4797607961884838 1.616499233676555 0.05081597578523038 0.1469546323529213 9.232533018194835e-07 6.034679130512166 -0.08049018424927867 QKDFLDGVYAFEYYPST(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 QKDFLDGVYAFEYYPSTPGR 20 1 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 QKDFLDGVYAFEYYPS(0.055)T(0.945)PGR 126.96 0.00028717 73503000.0 12163.0 11060.0 13981.0 13794.0 14725.0 12614.0 12839.0 12741.0 7796.0 10481.0 True False 12446.37423492188 9765.090058345495 12082.45699213581 11385.13684544898 13393.1263499099 12487.11461259564 11870.54389326179 12403.06729139934 13229.2426026884 11826.33844358542 1.052428382148387 0.8257069679620118 1.021656622611651 0.9626933052659467 1.1324829247698642 1.0558732672975906 1.0037378813304931 1.0487664758255533 1.1186254025956708 1.0 13.529715849088811 -6.166121463419678 9.468859198065427 1.0592942609661788 0.9592471187232553 0.31517281197559355 0.06783739224503187 0.4769658152196699 44.37070108205235 0.019388872589056316 0.025056662500016466 6.821478844356237e-07 6.166121463419678 -0.10004714224292355 QKDFLDGVYAFEYYPST(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 QKDFLDGVYAFEYYPSTPGR 20 1 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 QKDFLDGVYAFEYYPS(0.461)T(0.539)PGR;QKDFLDGVYAFEYYPS(0.231)T(0.769)PGR 162.73 6.6323e-07 12822400.0 135279.0 127673.0 137615.0 147421.0 157545.0 111367.0 122931.0 118288.0 108675.0 129651.0 True False 127760.73474474384 137465.10856660103 128761.00072388291 127342.00548459003 137752.78862983 126706.79336102949 128647.53508315525 118632.1984963673 130413.03663320503 125907.63875624686 1.0147178996191368 1.0917932376821795 1.0226623419819671 1.0113922137092894 1.0940780876410126 1.00634714948733 1.0217611604345367 0.9422160535155093 1.0357833561288563 1.0 16.942006287767356 -6.973007123623939 24.950008508374587 0.9978289906737059 1.0465102399013078 0.2997062912507015 0.034981131476112544 255.3818959190525 236053.35209476238 0.011914355313233812 0.010507300569919916 1.0641255634952693e-07 6.973007123623939 0.048681249227601864 QKEDVEVVGGS(ph)DGEGAIGLSSDPK ddPTM_A459_Selumetinib_30min_R1 3 QKEDVEVVGGSDGEGAIGLSSDPK 24 1 Q8NHZ8 Q8NHZ8 CDC26 Anaphase-promoting complex subunit CDC26 1 QKEDVEVVGGS(0.999)DGEGAIGLS(0.001)S(0.001)DPK;QKEDVEVVGGS(0.998)DGEGAIGLS(0.001)SDPK;QKEDVEVVGGS(0.953)DGEGAIGLS(0.021)S(0.025)DPK 141.3 1.9186e-08 253150000.0 22672.9 23305.7 28902.1 28612.7 25734.5 24020.399999999998 25222.8 25157.6 16559.6 22710.2 True False 23201.134456216412 20577.057809474012 24977.353567871265 23616.02907189924 23406.819018795006 23778.776584778207 23320.22388900721 24490.338724598398 28100.43173466892 25625.275386080863 0.9054003949873181 0.8029985043848956 0.9747155178452624 0.9215912303805717 0.9134270233641713 0.9279422845810416 0.9100477375425315 0.9557102647919663 1.0965904292264703 1.0 14.645279888401616 -8.05469904741695 4.098239725505552 1.0468505577879594 0.9088936785583309 0.5939384598327783 0.04578285968449651 0.15447496357423804 5.199922901703612 0.03290982551157663 0.012005003622446699 8.816596240954034e-09 8.05469904741695 -0.13795687922962852 QKEDVEVVGGS(ph)DGEGAIGLSSDPK ddPTM_A459_Selumetinib_30min_R2 2 QKEDVEVVGGSDGEGAIGLSSDPK 24 1 Q8NHZ8 Q8NHZ8 CDC26 Anaphase-promoting complex subunit CDC26 1 QKEDVEVVGGS(0.984)DGEGAIGLS(0.007)S(0.009)DPK;QKEDVEVVGGS(0.991)DGEGAIGLS(0.004)S(0.005)DPK 99.987 3.3209e-06 53452000.0 330760.0 287680.0 291920.0 344230.0 313840.0 249520.0 278650.0 284050.0 220380.0 288580.0 True False 312377.68333718844 309744.13096300536 273138.1850184639 297345.2801701287 274412.6134348015 283889.1150829609 291607.77713449986 284876.5384729911 264462.15793168405 280247.94557911484 1.114647540739967 1.1052503179744584 0.9746304632279852 1.0610078855553544 0.9791779663816804 1.0129926715299262 1.0405349324931201 1.0165160636032908 0.9436720664809498 1.0 18.096344271504314 -5.247356260315513 23.242878385339566 1.006993776391248 1.1099489998572418 0.6409025238065906 0.03176948822563155 191.01024173073623 315240.61765176704 0.007869357520808194 0.02054959739134071 5.6577498226525785e-06 5.247356260315513 0.10295522346599384 QKEDVEVVGGSDGEGAIGLSS(ph)DPK ddPTM_A459_Selumetinib_30min_R2 1 QKEDVEVVGGSDGEGAIGLSSDPK 24 1 Q8NHZ8 Q8NHZ8 CDC26 Anaphase-promoting complex subunit CDC26 1 QKEDVEVVGGS(0.3)DGEGAIGLS(0.327)S(0.373)DPK 53.25899999999999 0.01168 59222000.0 90454.0 78206.0 82845.0 90177.0 77756.0 55740.0 87998.0 82110.0 54598.0 84806.0 True False 85426.92879605168 84204.1487280756 77514.84289481604 77894.73703599807 67987.59613254039 63417.67904265882 92090.08136472903 82348.92650595783 65519.12559558068 82357.43042755018 1.0372704484897903 1.0224232141646281 0.941200356694055 0.9458131055281291 0.8255186663739961 0.7700298408222843 1.118175747915553 0.9998967437236908 0.7955460151615323 1.0 16.329611197775307 -5.288877963508938 2.281480029299139 0.9202791749772882 1.0393315367305214 0.15446271549131518 0.09979143079496604 0.6570126039993164 6.413769814093954 0.029259342892692313 0.0990849070971911 5.141881178392425e-06 5.288877963508938 0.1190523617532332 QKFNDS(ph)EGDDTEETEDYR ddPTM_A459_Selumetinib_30min_R1 3 QKFNDSEGDDTEETEDYR 18 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKFNDS(0.903)EGDDT(0.096)EET(0.001)EDYR;QKFNDS(0.966)EGDDT(0.028)EET(0.006)EDYR;QKFNDS(0.874)EGDDT(0.123)EET(0.003)EDYR 102.29 0.0012853 150849900.0 6934.300000000001 7634.599999999999 8445.3 9126.0 8072.700000000001 7505.0 8313.3 8019.8 5064.6 6665.9 True False 7095.855698201007 6740.737482770753 7298.474646712291 7532.315416236585 7342.525710350946 7429.506513994787 7686.221087923775 7807.088852018241 8594.256296251375 7521.533196364475 0.9434054883425604 0.8961919474115837 0.9703440051610756 1.0014335135657344 0.9762006652978608 0.9877649037812971 1.0218955214661423 1.0379650861332086 1.142620270612566 1.0 12.876811056848908 -6.577103302752507 0.5810013559969879 1.065063270030531 0.9209783365185287 0.5665274712400865 0.04047271699637216 0.67055327877004 0.49273222891446994 0.032624495304339814 0.04582813120840348 2.647870232335918e-07 6.577103302752507 -0.14408493351200224 QKFNDS(ph)EGDDTEETEDYR ddPTM_A459_Selumetinib_30min_R2 5 QKFNDSEGDDTEETEDYR 18 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKFNDS(0.94)EGDDT(0.045)EET(0.015)EDYR;QKFNDS(0.776)EGDDT(0.044)EET(0.18)EDYR;QKFNDS(0.991)EGDDT(0.008)EET(0.002)EDYR;QKFNDS(0.985)EGDDT(0.008)EET(0.007)EDYR;QKFNDS(0.987)EGDDT(0.009)EET(0.004)EDYR 98.887 0.0017395 611314600.0 471968.0 453668.0 502608.0 535660.0 480856.0 360281.0 400925.0 418516.0 310627.0 443467.0 True False 445737.90799759945 488462.87682746246 470270.74847821443 462702.18393495906 420446.57037281786 409906.4374447103 419568.8069178155 419733.8122709469 372761.0796435479 430662.9554443585 1.0350040614421703 1.1342115003215587 1.091969352211844 1.0743951344910603 0.9762775392162547 0.9518033354453911 0.9742393712152557 0.9746225138818013 0.8655517613743503 1.0 18.716199706316537 -6.2798897548353 2.7822800243385903 0.9531939014041307 1.0916421452782126 0.7119408498506239 0.03976414988472623 0.14369486043852675 2.2236399657720574 0.012622560740520023 0.0156461362607036 5.249406989425314e-07 6.2798897548353 0.13844824387408183 QKFNDSEGDDT(ph)EETEDYR ddPTM_A459_Selumetinib_30min_R1 1 QKFNDSEGDDTEETEDYR 18 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKFNDS(0.263)EGDDT(0.655)EET(0.082)EDYR 84.37100000000002 0.011126 25942000.0 3340.2 3088.6 3840.5 4078.9 3547.4 3078.4 4017.1 3222.9 1926.4 2886.9 True False 3418.020161102202 2726.9852761488155 3318.9811943564523 3366.596685435832 3226.53829634434 3047.4340909635657 3714.0869128142335 3137.418222545401 3268.960101310794 3257.4617357873035 1.0492894278852036 0.8371503634837706 1.0188857041337678 1.033503064195519 0.9905068909626072 0.935524140616505 1.140178216680285 0.9631481432542787 1.0035298543639566 1.0 11.669532516743562 QKFNDSEGDDT(ph)EETEDYR ddPTM_A459_Selumetinib_30min_R2 1 QKFNDSEGDDTEETEDYR 18 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKFNDS(0.3)EGDDT(0.677)EET(0.023)EDYR 71.946 0.028729 302380000.0 129330.0 110580.0 136080.0 154590.0 132560.0 111820.0 130410.0 101220.0 76888.0 121310.0 True False 122142.35634901012 119061.13042925883 127324.76095270147 133534.57531737548 115906.62769856412 127222.18999910486 136474.32340251261 101514.53344212695 92267.74843021733 117807.4650987676 1.0367964054451748 1.0106416459215057 1.080786865636696 1.1334984179943313 0.9838648815793646 1.0799161996435804 1.1584522533278776 0.8616986483583111 0.7832079941017469 1.0 16.84607143567427 -7.777488580797502 24.996169617561748 0.8668398581829133 1.0669453037607255 0.5993246383452354 0.06992599794262001 157.09729957770395 244671.05254160488 0.037286476991818876 0.018000774791831688 1.6692116963613393e-08 7.777488580797502 0.20010544557781218 QKFNDSEGDDTEET(ph)EDYR ddPTM_A459_Selumetinib_30min_R1 1 QKFNDSEGDDTEETEDYR 18 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKFNDS(0.029)EGDDT(0.186)EET(0.785)EDYR 86.258 0.01014 122870000.0 2782.7 2815.9 3626.9 3758.7 3299.6 3124.2 3402.5 3208.4 1973.5 3150.5 True False 2847.531495808362 2486.2131189236065 3134.3869011356373 3102.313604537416 3001.1517625916936 3092.7733845466378 3145.8466856315354 3123.302809648039 3348.8853612629014 3554.8973634687386 0.8010165145892834 0.6993769059193459 0.8817095349490534 0.8726872501067913 0.8442302141919731 0.8700035664401919 0.8849331960914713 0.8785915570289304 0.9420483965801988 1.0 11.795592191805731 -1.522878746006388 0.10383015835449062 1.0675899524046586 0.1577103117171367 0.7042167373393506 0.041061447843425344 67.7466471047189 0.49758618544582295 0.47189695850218866 8.794113859464632 0.029999999949846215 1.522878746006388 -0.9098796406875219 QKNS(ph)PLLSVSSQTITK ddPTM_A459_Selumetinib_30min_R2 2 QKNSPLLSVSSQTITK 16 1 Q8ND24;E9PRE9 Q8ND24 RNF214 RING finger protein 214 1 QKNS(0.999)PLLS(0.001)VSSQTITK;QKNS(0.973)PLLS(0.023)VS(0.003)SQTITK 63.13399999999999 0.034506 13754700.0 89241.0 69156.0 77161.0 92399.0 93667.0 74527.0 85751.0 77742.0 67767.0 74275.0 True False 84281.34248002793 74460.04282841201 72196.54526654481 79814.09680283436 81899.71406639564 84792.41776125286 89738.59141238307 77968.21634911901 81322.29356818422 72130.48776037412 1.1684565722059217 1.0322963997661703 1.000915805621475 1.106523736093205 1.1354382399087057 1.1755419988693705 1.2441145789905805 1.0809328866337147 1.1274330188691688 1.0 16.138321559179275 -4.444424381300805 20.672234557763243 1.1074649692994538 3.7226259083161093 0.064719565410711 0.07331126801447801 5855876.236867337 10751669.200124588 0.019633445567444528 706977379.7125957 3.5939796913924976e-05 4.444424381300805 2.6151609390166555 QKS(ph)DAEEDGGTVS(ph)QEEEDR ddPTM_A459_Selumetinib_30min_R2 1 QKSDAEEDGGTVSQEEEDR 19 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 2 QKS(1)DAEEDGGT(0.023)VS(0.977)QEEEDR 133.47 0.00044624 15685000.0 136380.0 59088.0 95384.0 92242.0 62540.0 104880.0 227310.0 119830.0 120510.0 77049.0 True False 128800.54557239615 63619.859602134544 89247.09728624705 79678.48047367454 54683.166085306235 119326.26799415248 237880.36540621973 120178.68546107571 144615.36733073407 74824.39517265659 1.7213710217795961 0.8502555811554817 1.1927540086399657 1.0648730309121404 0.7308200214532352 1.5947508525636358 3.1791819346793653 1.6061430925537659 1.9327301877554168 1.0 16.19122109159644 -6.998255969200005 24.403627195624686 2.038160071106441 1.1056835257770548 0.3138275373670333 0.5631647446738823 43.44937198688884 607956.2221833522 0.19194378720762703 0.16803862020349364 1.004023853367816e-07 6.998255969200005 -0.9324765453293864 QKS(ph)DAEEDGGTVSQEEEDR ddPTM_A459_Selumetinib_30min_R1 2 QKSDAEEDGGTVSQEEEDR 19 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKS(1)DAEEDGGTVSQEEEDR;QKS(1)DAEEDGGTVSQEEEDR 166.35 3.6453e-09 28380000.0 2263.97 3786.8 2118.8199999999997 1736.6 2613.74 3071.1 3465.2 3665.9 1777.97 3995.6000000000004 True False 2316.7160960812366 3343.439695564443 1831.09588184516 1433.3354100193337 2377.3276784932777 3040.207522335694 3203.8171741514743 3568.6684234786007 3017.085232209068 4508.474180439833 0.5138581265769221 0.741590072772307 0.4061453628345996 0.317920288029575 0.5273020501719615 0.6743318028803928 0.7106211649278914 0.7915468250791785 0.6692031741689448 1.0 12.138423544136874 -7.017175033768989 1.8561442477237182 0.7853095380209493 0.49821105364946944 0.5377325448226193 0.1284127500842337 0.31516936598380413 2.1792837033596935 0.06225396694568298 0.047153350504959356 9.612247977339514e-08 7.017175033768989 -0.28709848437147983 QKS(ph)DAEEDGGTVSQEEEDR ddPTM_A459_Selumetinib_30min_R2 2 QKSDAEEDGGTVSQEEEDR 19 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKS(1)DAEEDGGTVSQEEEDR;QKS(1)DAEEDGGTVSQEEEDR 155.24 1.9956e-06 46387600.0 96734.0 24995.0 55044.0 63076.0 31836.0 35730.7 142869.0 76105.0 73041.0 43810.0 True False 91357.9115368834 26912.03612840769 51502.5289673758 54484.93998783087 27836.47706254892 40652.279593999476 149512.69158955268 76326.45295013892 87651.24093605629 42545.09146794997 2.1473196644953756 0.6325532558481168 1.2105398576043407 1.280639860155793 0.65428175383096 0.955510452354383 3.5142171853639907 1.7940131356313358 2.0601963214037426 1.0 15.376705073779446 QKS(ph)DAEEDGGTVSQEEEDRKPK ddPTM_A459_Selumetinib_30min_R1 2 QKSDAEEDGGTVSQEEEDRKPK 22 3 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKS(1)DAEEDGGTVSQEEEDRKPK;QKS(1)DAEEDGGTVSQEEEDRKPK 80.596 0.00081351 75495000.0 3068.0 4414.7 5761.700000000001 5055.3 3535.8 5322.7 4204.3 4515.9 2853.9 4364.9 True False 3139.4784307112 3897.8248716616527 4979.292786752652 4172.486754733813 3215.987514296193 5269.158470624927 3887.1662660986512 4396.123662289479 4842.859859391026 4925.177432726454 0.6374345845593757 0.7914080101483604 1.0109874932965088 0.8471749113054856 0.6529688642132642 1.0698413493923717 0.7892439042438344 0.8925817845827122 0.9832863740525467 1.0 12.265959984196288 -4.9076280934634635 3.6460260328422622 0.8932024313273592 0.6376633809117331 0.33403802606881605 0.11667255322000086 0.2893809827460199 6.8331072872582626 0.028965233793230995 0.1631107820566068 1.2370062859454204e-05 4.9076280934634635 -0.2555390504156261 QKS(ph)DAEEDGGTVSQEEEDRKPK ddPTM_A459_Selumetinib_30min_R2 3 QKSDAEEDGGTVSQEEEDRKPK 22 3 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKS(1)DAEEDGGTVSQEEEDRKPK;QKS(1)DAEEDGGTVSQEEEDRKPK;QKS(1)DAEEDGGTVSQEEEDRKPK 78.441 0.0010112 117645000.0 241733.0 65781.0 156067.0 158509.0 63906.0 67283.0 236472.0 145846.0 102448.0 104471.0 True False 228298.4475938701 70826.19118074767 146025.81913290164 136919.80075672356 55877.55695311132 76550.62251573753 247468.41656037874 146270.38771389495 122940.46263628798 101454.65078174378 2.2502511795639752 0.6981068944105268 1.439321095757773 1.3495665275244488 0.5507638784674245 0.7545304421816846 2.439202290417911 1.4417317154692284 1.211777495550854 1.0 16.6304754756178 -14.522363468163682 0.0131750049356464 2.5582258461475234e-05 2.342197655752796 0.01426087145994348 0.5923739464893272 112017.14223277768 111.60817099019658 12093.882267260562 8114.855455045442 3.003561520622546e-15 14.522363468163682 2.3421720734943348 QKS(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R2 1 QKSFSEDVISHK 12 1 F8W9J4;Q03001;E9PHM6;F6QMI7;Q03001-8;Q03001-14;H0YC82;Q03001-10;A0A494C1D7 F8W9J4;A0A494C1D7 DST Dystonin 1 QKS(0.854)FS(0.146)EDVISHK 64.454 0.044696 6326600.0 65068.0 63799.0 73060.0 79419.0 71951.0 55626.0 58767.0 53527.0 46623.0 54663.0 True False 61451.78104784183 68692.178153882 68359.3991417134 68601.99519458324 62911.87212989881 63287.9765774478 61499.78194460137 53682.75470812809 55948.90275546283 53084.7371584695 1.157616752709821 1.2940099514634666 1.2877411248669406 1.2923111023379723 1.1851216658018513 1.1922066485611373 1.15852098430875 1.0112653388086557 1.0539545969389124 1.0 15.696009498752005 -7.458348574923546 1.0205858818394147 1.0040547090671825 1.257355667943442 0.8119849647106184 0.04595401859117636 0.22068186040046167 0.4295245656706617 0.03655216897511002 0.017851350747278956 3.4805784351814266e-08 7.458348574923546 0.25330095887625936 QKS(ph)PAQSDSTTQR ddPTM_A459_Selumetinib_30min_R1 1 QKSPAQSDSTTQR 13 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 QKS(1)PAQSDSTTQR 77.64399999999998 0.023481 24491000.0 662.91 1128.6 765.63 906.34 905.33 781.57 675.81 971.02 596.31 807.88 True False 678.3545132016827 996.462987328094 661.6616513045515 748.0647331089044 823.4430613489932 773.7081154087816 624.8331076022471 945.26539528252 1011.8945172407805 911.5792674175925 0.7441530730765622 1.0931172120126953 0.7258410485562806 0.8206249964724325 0.9033148194360762 0.8487557177563008 0.685440235353677 1.0369535914966086 1.1100455587448477 1.0 9.832224302690834 -7.888692434490489 8.508185368963554 1.0608192758792525 0.8408305836703057 0.4495325772824229 0.10996208978822296 0.22628495968227025 15.914986782445574 0.05873679426480015 0.028128756910908864 1.29213403350118e-08 7.888692434490489 -0.2199886922089468 QKS(ph)PAQSDSTTQR ddPTM_A459_Selumetinib_30min_R2 1 QKSPAQSDSTTQR 13 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 QKS(0.999)PAQS(0.001)DSTTQR 65.652 0.041395 26162000.0 1134.3 1130.1 1237.9 2703.3 2532.7 2516.4 3784.2 5313.7 3011.0 2781.9 True False 1071.2601469626695 1216.7750361557717 1158.254861723612 2335.1058765473895 2214.5195833747216 2863.011258395168 3960.1727982500433 5329.161987269611 3613.28413436927 2701.5793187557642 0.39653107333381854 0.45039397055947555 0.4287325023856995 0.8643484425335484 0.8197129612298919 1.0597546548119685 1.4658732285802125 1.972609854640138 1.3374710523152062 1.0 11.399587324982306 -6.651089433309755 1.0610233648415541 1.5283456913826277 0.4472364465532624 0.723776572857908 0.25313546687254534 0.2480831567848018 0.5986924564507281 0.13238071230884624 0.13407506302656033 2.2331123155589295e-07 6.651089433309755 -1.0811092448293653 QKS(ph)PEIHR ddPTM_A459_Selumetinib_30min_R1 1 QKSPEIHR 8 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKS(1)PEIHR 82.417 0.02275 92223000.0 2532.7 3193.2 2714.6 2118.9 2273.0 2972.3 1727.2 2564.3 3078.0 2713.7 True False 2591.706982223682 2819.3386595215948 2345.972230230446 1748.8738916791256 2067.407551330745 2942.4013606324725 1596.9159134233023 2496.2864339796965 5223.1411917746145 3062.029828676437 0.8464016117517537 0.9207417357982611 0.7661493719819487 0.5711485483585497 0.6751755100388366 0.9609316451056018 0.5215219977506129 0.8152390974776091 1.7057773712257789 1.0 11.580272621540926 -8.142578411770398 7.1807713869933565 1.34753409677502 0.7512794126977543 0.57208806134348 0.2056802378943307 0.16226524815642887 8.738193645370318 0.13352328298445307 0.049846177567996634 7.201477169925819e-09 8.142578411770398 -0.5962546840772657 QKS(ph)PEIHR ddPTM_A459_Selumetinib_30min_R2 2 QKSPEIHR 8 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 QKS(1)PEIHR;QKS(1)PEIHR 72.2 0.036621 531230000.0 95044.0 69100.0 60902.0 65251.0 61221.0 56944.0 95174.0 173003.0 100152.0 123121.0 True False 89761.83497127757 74399.74780848055 56983.63162508394 56363.70123574659 53529.87065731581 64787.51911383503 99599.77958370313 173506.4100878114 120185.19848068789 119566.17682322438 0.7507293229253973 0.6222474430915251 0.47658654929924554 0.4714017185569036 0.4477007802671352 0.5418549027424517 0.8330096539839935 1.4511328763512805 1.005177230500384 1.0 16.867449808533095 -7.512704712475216 4.172622953716613 1.1730506799671878 0.5485670116224591 0.775701026011175 0.14431262838699288 0.09044004247288859 3.7334972482823408 0.06825890748177996 0.04086236983594055 3.0711094016622426e-08 7.512704712475216 -0.6244836683447287 QKSDAEEDGGT(ph)VSQEEEDRKPK ddPTM_A459_Selumetinib_30min_R2 1 QKSDAEEDGGTVSQEEEDRKPK 22 3 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKSDAEEDGGT(0.5)VS(0.5)QEEEDRKPK 45.237 0.043541 33783000.0 23023.0 6848.0 17049.0 12275.0 5187.4 6164.2 19119.0 11153.0 10497.0 8377.7 True False 21743.473828371294 7373.21958020947 15952.085901547664 10603.12382444391 4535.712436055605 7013.262596963721 20008.07138357979 11185.453383521452 12596.69331068557 8135.8140331213035 2.6725627871842366 0.906266975891131 1.960724008268371 1.303265264087658 0.5574995221855483 0.8620234642055952 2.4592586927535387 1.374841329704061 1.5483015294356293 1.0 12.990070987387497 -11.051742680158874 7.226510831062974 0.9998105108596171 1.4811208817130357 0.051403103193249255 0.6496585868750333 0.0019701146838279216 0.00012844308736517667 0.6248305435141794 0.15148551709896985 8.876818084637336e-12 11.051742680158874 0.48131037085341855 QKSDAEEDGGTVS(ph)QEEEDR ddPTM_A459_Selumetinib_30min_R1 1 QKSDAEEDGGTVSQEEEDR 19 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKSDAEEDGGT(0.003)VS(0.997)QEEEDR 118.08 0.00024983 5069300.0 654.44 939.02 578.03 642.54 766.13 798.32 951.96 882.42 381.76 929.93 True False 669.6871786814336 829.079101861445 499.5367008915142 530.3324509696095 696.8336767712375 790.2896256165651 880.1528907726074 859.0153550958803 647.8188373527872 1049.2955737852678 0.6382254870909053 0.7901292281931527 0.476068624867507 0.5054176003587516 0.6640966512966922 0.7531620692591363 0.8388035866743545 0.8186590857302832 0.6173845135130243 1.0 10.035205409450025 -6.751685042220684 2.9015380962059942 0.8019576728724116 0.605432556253391 0.4079209902829396 0.11750303615071371 0.2929444988684163 5.069967190400831 0.04410814780116045 0.04121935459255989 1.771393137178807e-07 6.751685042220684 -0.1965251166190206 QKSDAEEDGGTVS(ph)QEEEDR ddPTM_A459_Selumetinib_30min_R2 3 QKSDAEEDGGTVSQEEEDR 19 1 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKSDAEEDGGT(0.009)VS(0.991)QEEEDR;QKSDAEEDGGT(0.022)VS(0.978)QEEEDR;QKSDAEEDGGT(0.058)VS(0.942)QEEEDR 132.24 0.0001381 25468900.0 82784.0 21820.7 57368.0 61545.0 30849.6 37712.0 132521.0 82823.0 91853.0 41703.6 True False 78183.19669060888 23494.277525390888 53677.00533755568 53162.464828953176 26973.997449076807 42906.48568454881 138683.48908537976 83064.00121791415 110226.16658725358 40499.508709034446 1.9304727188744422 0.5801126550493164 1.3253742341220465 1.3126693760878618 0.6660327077760223 1.0594322512109247 3.424325220380831 2.0509878728327537 2.721666758457858 1.0 15.30561678662477 -7.225057003672503 24.491618362202917 2.3868274318336153 1.1139301687715697 0.4142424703946995 0.6681383861069533 385.12244280677 259254.09832265208 0.2378987929586198 0.18426907014500848 5.955839645447648e-08 7.225057003672503 -1.2728972630620456 QKSDAEEDGGTVS(ph)QEEEDRKPK ddPTM_A459_Selumetinib_30min_R1 1 QKSDAEEDGGTVSQEEEDRKPK 22 3 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 QKSDAEEDGGT(0.141)VS(0.859)QEEEDRKPK 54.857 0.018765 11974000.0 1834.3 2326.2 3679.9 2767.5 2909.9 3646.3 2809.4 3283.8 1861.8 2820.1 True False 1877.0356210735179 2053.8474225789582 3180.189792243799 2284.2080774090214 2646.7000587845714 3609.621532575509 2597.4846961390826 3196.7029567143204 3159.338619508118 3182.0873051002036 0.5898755882860386 0.6454403118629338 0.9994036892534773 0.7178332516986337 0.8317496677550231 1.1343565359724919 0.816283290523133 1.0045931020153631 0.9928510177720064 1.0 11.635757703268578 -4.1384111998181545 0.4663684554932084 0.9849450623791508 8.185541005819918e-14 0.5537273958918247 0.11435575287630384 6.6819777289980165 0.7154533065750227 0.07442808964499766 4.104742089115771 7.270910523053224e-05 4.1384111998181545 -0.984945062379069 QKSNSQS(ph)DS(ph)HDEEVSPTPPNPVVK ddPTM_A459_Selumetinib_30min_R2 1 QKSNSQSDSHDEEVSPTPPNPVVK 24 1 C9J4C2;C9IZL8;C9JR00;C9JSK5;P31321 C9J4C2 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit 2 QKS(0.437)NS(0.513)QS(0.525)DS(0.525)HDEEVSPTPPNPVVK 66.36 0.0050887 3820600.0 43027.0 24928.0 20808.0 18911.0 17892.0 18288.0 43406.0 32444.0 23779.0 15188.0 True False 40635.731590728035 26839.89744384663 19469.235934037406 16335.289176705406 15644.247003490555 20807.005998065022 45424.46500735732 32538.406668606647 28535.464440772816 14749.482976836889 2.755061425172925 1.81971784950001 1.3199944679154234 1.107516053434478 1.0606640943319054 1.4106939226779056 3.079732698338885 2.2060710005704007 1.9346755737530543 1.0 13.848376763188222 QKVDSLLENLEK ddPTM_A459_Selumetinib_30min_R1 2 QKVDSLLENLEK 12 1 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7;G3V576;A0A0G2JNQ3;B2RXH8;O60812;A0A0G2JPF8;P0DMR1;B7ZW38 B4DY08;G3V2Q1;A0A0G2JNQ3;O60812 HNRNPC;HNRNPCL2;HNRNPCL1;HNRNPCL4;HNRNPCL3 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3 0 ; 148.52 0.0016927 15742500.0 8948.2 7192.200000000001 9789.0 8599.6 8867.599999999999 8461.599999999999 7718.0 9223.3 7433.4 8590.7 False True 9156.675649833758 6350.133880436929 8459.70756712806 7097.841294484783 8065.527145701939 8376.48398651809 7135.825046202554 8978.668122499299 12613.93688594459 9693.400025504176 0.9446299157923691 0.6550987129107616 0.8727286137856517 0.7322344353694006 0.8320637881941154 0.8641430214866646 0.7361529522590196 0.926266129415442 1.3012912757913868 1.0 13.242787074096785 -8.046550660757438 5.361987947640763 1.1462865456760403 0.8038096681789811 0.6366910752384008 0.1032616500705175 0.11475032948677547 7.752720280277632 0.06395077243530695 0.024255534414386087 8.983577923885837e-09 8.046550660757438 -0.34247687749705913 QLAEPAS(ph)EPDVLK ddPTM_A459_Selumetinib_30min_R1 2 QLAEPASEPDVLK 13 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 QLAEPAS(1)EPDVLK;QLAEPAS(1)EPDVLK 158.29 0.00036465 12612300.0 3290.7 4305.5 4475.2 4701.2 3927.0 4026.2000000000003 4648.5 4397.4 2333.37 3801.8 True False 3367.3669074124336 3801.410058427353 3867.492420513996 3880.223672453585 3571.8035433681616 3985.70008349711 4297.859902471179 4280.766667231731 3959.5584673980325 4289.798062667976 0.7849709609216778 0.886151283322442 0.9015558224455597 0.9045236199394284 0.8326274316853813 0.9291113533251639 1.0018793051993196 0.9978946805177518 0.9230174496688182 1.0 12.066694020768148 -6.986237280604753 4.621943912234459 0.9793872184037734 0.8681788845568837 0.6687697845301376 0.03933404771383767 0.1262200869077201 6.940102342514403 0.014852406250641286 0.012467537548706529 1.032197301611905e-07 6.986237280604753 -0.11120833384688966 QLAEPAS(ph)EPDVLK ddPTM_A459_Selumetinib_30min_R2 2 QLAEPASEPDVLK 13 0 Q8IWI9;Q8IWI9-3 Q8IWI9 MGA MAX gene-associated protein 1 QLAEPAS(1)EPDVLK;QLAEPAS(1)EPDVLK 189.8 0.00015892 14593000.0 104931.0 103199.0 111036.0 119254.0 116055.0 91143.0 103786.0 107418.0 87890.0 111239.0 True False 99099.35509207426 111114.03146291415 103892.06464685615 103011.3994753756 101475.13335513607 103697.12093622272 108612.2546480574 107730.56859599268 105470.45585178204 108027.24103636816 0.9173552350440176 1.0285741855196209 0.9617209849123161 0.9535687340260413 0.9393476347412569 0.9599164057268882 1.0054154267578888 0.9972537256572571 0.9763320329200543 1.0 16.721035634533806 -7.251369523393251 23.902991631233785 0.994521440173532 0.9620300464768006 0.27614209056088046 0.027389092116771888 565.908416437769 1343309.5646419902 0.010582295080623218 0.008090354445863791 5.6057080631163414e-08 7.251369523393251 -0.032491393696731374 QLDWRPER ddPTM_A459_Selumetinib_30min_R2 1 QLDWRPER 8 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 0 111.95 0.032074 1778900.0 5557.8 5089.3 3358.5 7337.3 7498.9 4613.7 5258.5 4897.6 4610.3 6288.8 False True 5248.919725636191 5479.632945321272 3142.4177664583185 6337.947082451515 6556.821140983416 5249.195296001346 5503.030669520074 4911.85120515867 5532.488822544885 6107.226003735308 0.8594605345251415 0.8972376234267101 0.5145409330744186 1.0377783757429466 1.073616914941927 0.8595056565437119 0.9010687775684583 0.8042687796643646 0.9058922691187616 1.0 12.576301519139976 -5.820589031226786 24.999999966347062 0.9327020435654585 0.7710748492272148 0.31877021862780497 0.12187663131529337 100.62378604629377 42528.55716694377 0.03565237573109181 0.05288105095516733 1.5115098051012384e-06 5.820589031226786 -0.16162719433824368 QLEDELVSLQK ddPTM_A459_Selumetinib_30min_R2 1 QLEDELVSLQK 11 0 P09493-3;P09493-9;A0A0S2Z4G6;P09493-4;P09493-10;P09493;H0YKP3;A0A087WTJ7 P09493-3 TPM1 Tropomyosin alpha-1 chain 0 156.01 0.0075035 2304800.0 13318.0 11638.0 15989.0 16195.0 20984.0 12669.0 16551.0 14433.0 12335.0 17066.0 False True 12577.838876178126 12530.597177931924 14960.285147506938 13989.213062066736 18347.802320659837 14414.039752268476 17320.654295184315 14474.99764048822 14802.344668696442 16573.2602372069 0.7589236333802887 0.7560731563124065 0.9026760536783921 0.8440833524511375 1.1070726011692675 0.8697166125412679 1.0450963809944598 0.873394699251262 0.8931462160634658 1.0 14.01656981224695 -5.43605122224025 1.5060635921058032 0.9540816217542654 0.7413003663227856 0.4823052238740977 0.07852337796057275 0.40159457591511977 1.6401413525681967 0.023389514999018892 0.08712832842018817 3.663943582418575e-06 5.43605122224025 -0.21278125543147974 QLEELEEEFCR ddPTM_A459_Selumetinib_30min_R2 1 QLEELEEEFCR 11 0 M0QZR4;Q92888-2;Q92888;Q92888-3 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 0 119.45 0.045857 0.0 2718.0 2479.4 4160.1 2862.6 4286.8 2317.6 2221.6 3278.5 2681.6 2764.8 False True 2566.9444410160772 2669.5620074724543 3892.4436951744065 2472.7089417395628 3748.2538595217593 2636.828362921891 2324.9088020168847 3288.039892215107 3217.994930164279 2684.9730401869 0.956041048679354 0.9942602653792855 1.4497142566852197 0.9209436760554729 1.3960117302559003 0.9820688414578428 0.8658965163594524 1.224608159188901 1.1985203881005357 1.0 11.39069188684524 QLEEPGAGTPS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 4 QLEEPGAGTPSPVR 14 0 Q96P11-2;Q63ZY6;Q96P11-5;Q96P11;Q96P11-4;Q63ZY6-4;Q63ZY6-5 Q96P11-2 NSUN5;NSUN5P2 Probable 28S rRNA (cytosine-C(5))-methyltransferase;Putative methyltransferase NSUN5C 1 QLEEPGAGTPS(1)PVR;QLEEPGAGT(0.003)PS(0.997)PVR;QLEEPGAGT(0.001)PS(0.999)PVR;QLEEPGAGT(0.008)PS(0.992)PVR 203.92 2.9759e-05 135758000.0 15055.4 14047.599999999999 16149.2 15929.400000000001 17314.4 13579.399999999998 13805.4 15038.900000000001 8365.0 13016.7 True False 15406.161527291199 12402.900461447935 13956.22734120589 13147.629321871473 15748.315577105595 13442.803565108694 12764.0475632087 14640.019518768193 14194.794044572669 14687.520238395036 1.0489287011852104 0.8444516337771698 0.9502099139051768 0.8951565075976479 1.0722242639664594 0.915253449657724 0.8690403387388611 0.9967659129072945 0.9664527309018225 1.0 13.842303219163226 QLEEPGAGTPS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 4 QLEEPGAGTPSPVR 14 0 Q96P11-2;Q63ZY6;Q96P11-5;Q96P11;Q96P11-4;Q63ZY6-4;Q63ZY6-5 Q96P11-2 NSUN5;NSUN5P2 Probable 28S rRNA (cytosine-C(5))-methyltransferase;Putative methyltransferase NSUN5C 1 QLEEPGAGT(0.01)PS(0.99)PVR;QLEEPGAGTPS(1)PVR;QLEEPGAGT(0.059)PS(0.941)PVR;QLEEPGAGTPS(1)PVR 244.0 5.900000000000001e-20 166883000.0 191014.0 181479.0 197242.0 213949.0 237158.0 175287.0 185854.0 181497.0 169762.0 199239.0 True False 180398.20656962646 195397.85575304227 184551.66446085233 184808.77711738867 207364.09182057946 199431.19315304165 194496.57926271454 182025.12622155403 203719.1435465946 193486.4523849099 0.9323557507310822 1.0098787452277533 0.9538221523319718 0.9551509929477728 1.071724088506529 1.0307243256303322 1.0052206594588604 0.9407641929340075 1.0528858275892536 1.0 17.561873029119944 -6.185818667624536 24.999999733639058 1.0140351438017698 0.9655230407382708 0.3303606866964769 0.03751165418650901 176.73672516030928 58427.63163932424 0.01129796314649215 0.014585603616202179 6.519005273738651e-07 6.185818667624536 -0.04851210306349907 QLEHVMDSAAEDPQS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 QLEHVMDSAAEDPQSPK 17 0 C9JKA9;Q9NS87-4;Q9NS87-2;Q9NS87;Q9NS87-3 C9JKA9 KIF15 Kinesin-like protein KIF15 1 QLEHVMDSAAEDPQS(1)PK 121.48 0.00094322 3322600.0 20198.0 18361.0 17931.0 21416.0 22029.0 15229.0 18788.0 21288.0 16831.0 24573.0 True False 19075.47601900028 19769.22966007975 16777.338981796653 18499.10385533936 19261.520078241298 17326.656514902254 19661.679227715715 21349.94455558188 20197.670297432483 23863.513641678474 0.7993573915990428 0.8284291222543225 0.7030540109774294 0.7752045291029573 0.8071535636981961 0.7260731497913464 0.8239222238160224 0.8946689442368387 0.8463829174827187 1.0 14.542518859306014 -8.441162414356798 0.7104938093602537 0.9959278614408722 0.7716200530189882 0.7118655219609362 0.042893027903111176 0.3877166738673476 0.44974772438600386 0.04279793464336842 0.017116087991418113 3.621075546881804e-09 8.441162414356798 -0.22430780842188403 QLEMENS(ph)PLLSPR ddPTM_A459_Selumetinib_30min_R1 1 QLEMENSPLLSPR 13 0 Q9HCM4-4;Q9HCM4-3;Q9HCM4 Q9HCM4-4 EPB41L5 Band 4.1-like protein 5 1 QLEMENS(0.862)PLLS(0.138)PR 93.106 0.017559 9680200.0 742.03 901.82 1086.9 827.28 1049.5 675.22 1072.8 996.07 340.1 691.14 True False 759.317855260962 796.2344951552565 939.3049499143408 682.8110779689015 954.5729103042745 668.4278998507077 991.8778322837643 969.650987908652 577.1248600788005 779.8545512736973 0.9736659919735112 1.0210038446974588 1.2044617145341028 0.8755620863578989 1.2240396734817005 0.8571186752183442 1.271875416593748 1.2433741475573485 0.7400416643542201 1.0 9.607061265386637 -5.003901754642305 23.56237050121208 1.0648951771244934 0.9855002851198787 0.014236237515853123 0.1756134063317861 368.0067238536955 2222641.4513153355 0.041550388734400014 0.14645614358442643 9.910561145617315e-06 5.003901754642305 -0.07939489200461469 QLEMENS(ph)PLLSPR ddPTM_A459_Selumetinib_30min_R2 2 QLEMENSPLLSPR 13 0 Q9HCM4-4;Q9HCM4-3;Q9HCM4 Q9HCM4-4 EPB41L5 Band 4.1-like protein 5 1 QLEMENS(0.879)PLLS(0.121)PR;QLEMENS(0.998)PLLS(0.002)PR 161.94 0.0003635 26794000.0 84559.0 57478.0 69594.0 71184.0 58236.0 64131.0 86524.0 79627.0 59129.0 48953.0 True False 79859.54929649684 61886.37777910048 65116.397808218055 61488.61640075073 50919.873043554406 72964.46312674474 90547.53744405348 79858.70138704056 70956.45220229846 47539.5996948312 1.6798532130925719 1.301785841201123 1.3697296196479734 1.2934188927854213 1.0711043713119597 1.534814419875687 1.9046760600699455 1.6798353772365335 1.4925757191433247 1.0 15.53684213472897 -6.979628888092067 24.967983338696776 1.596470573669991 1.335926382377269 0.07858042403881971 0.2571075811556015 393.3896096085818 482159.0528042108 0.08826514888911809 0.0778340131781601 1.0480237193464715e-07 6.979628888092067 -0.260544191292722 QLFHPEQLITGK ddPTM_A459_Selumetinib_30min_R1 2 QLFHPEQLITGK 12 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;Q9NY65;Q9NY65-2;C9J2C0;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;C9K0S6;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA8;TUBA1A;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 169.62 0.00047787 47959000.0 20473.0 20863.0 19410.5 19805.9 20868.0 18872.9 21590.0 21174.0 15171.0 19793.199999999997 False True 20949.981066476677 18420.350261054427 16774.660714244485 16347.171367788758 18980.493084544632 18683.05576122215 19961.448917791284 20612.396737154813 25744.078954000222 22333.850022094735 0.9380371519353355 0.8247727213548623 0.7510868344530576 0.7319459632627875 0.8498531630581987 0.836535382065301 0.893775542418506 0.9229217853958498 1.1526932852388536 1.0 14.446944351220692 -7.874087890253351 1.755882079554856 1.0715531606376931 0.8177687318888028 0.6670498558514342 0.06766531842034307 0.22000949462560618 1.2650625521033418 0.05586070819726825 0.020290731086343213 1.336325050681886e-08 7.874087890253351 -0.2537844287488903 QLFHPEQLITGK ddPTM_A459_Selumetinib_30min_R2 2 QLFHPEQLITGK 12 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;Q9NY65;Q9NY65-2;C9J2C0;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;C9K0S6;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA1B;TUBA8;TUBA1A;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 166.7 3.61e-05 2590800.0 77102.0 63412.0 74537.0 85742.0 85154.0 69785.0 75905.0 78163.0 65387.0 69309.0 False True 72816.97950376073 68275.49649828306 69741.37056974931 74063.79168679989 74456.19323358125 79397.25030484294 79434.73290290414 78390.44138941876 78466.22706542796 67307.86908359155 1.0818494255601416 1.0143761409752816 1.03615478426654 1.1003734436283812 1.1062033941545824 1.1796131921252364 1.1801700749767 1.164654927525093 1.165780883182894 1.0 16.03848756230802 -6.121912568641788 1.7918541608584972 1.1490381489687311 1.0413192212487155 0.3382019392103509 0.05332274271078532 0.32912890756152036 2.0960280600169336 0.017257989747402964 0.025522833400572417 7.552442567323973e-07 6.121912568641788 -0.10771892772001568 QLGAQS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 2 QLGAQSPGR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QLGAQS(1)PGR;QLGAQS(1)PGR 100.09 0.018229 39201000.0 6269.700000000001 7483.1 4502.9 3959.3999999999996 6305.5 5573.0 7342.5 7222.6 4311.299999999999 7627.200000000001 True False 6415.7718112874845 6606.9751732011955 3891.4309126592048 3267.965117143011 5735.168638326447 5516.940679879141 6788.649313519332 7031.033185688792 7315.961215106536 8606.225415219413 0.7454803356581517 0.7676972022505122 0.4521646511579309 0.37972106928129945 0.6663976786134681 0.641040690163992 0.7888068213405328 0.8169706051685539 0.8500778055579221 1.0 13.071164912673181 -7.704395732224101 0.9446157478971792 0.9528685246916063 0.5901317185641956 0.5667876673582948 0.11554457538379562 0.47287688413758844 0.7680704210476765 0.11328078639997893 0.048472293608479745 1.9751690317878536e-08 7.704395732224101 -0.36273680612741077 QLGAQS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 QLGAQSPGR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QLGAQS(1)PGR;QLGAQS(1)PGR 90.913 0.027914 66944000.0 143716.0 112764.0 118335.0 161798.0 177792.0 149879.0 205834.0 219726.0 257770.0 103237.0 True False 135728.84006073093 121412.63620659181 110721.45493340622 139760.83328288206 155456.17947935357 170523.47178390148 215405.68885233335 220365.3662824025 309331.2026955717 100256.27956806113 1.353818839533024 1.2110227581721524 1.1043842381787226 1.394035704147613 1.5505879546808716 1.7008757208882657 2.148550592345695 2.198020585162476 3.0854047649511624 1.0 16.61333307738108 -6.903574099612929 1.373037794809769 2.229331805233113 1.2502488079012655 0.3699816403102061 0.48162174551290404 0.394924108479243 1.5388323696773072 0.23169231794220682 0.18463380350667227 1.2486073881931922e-07 6.903574099612929 -0.9790829973318473 QLHDDYFYHDEL ddPTM_A459_Selumetinib_30min_R1 2 QLHDDYFYHDEL 12 0 A8MXP8;Q14257;Q14257-2 A8MXP8 RCN2 Reticulocalbin-2 0 ; 136.7 0.0019466 14203000.0 5224.1 5526.9 6364.3 7019.7 6531.6 5515.6 5655.4 5873.9 3328.3999999999996 4738.9 False True 5345.811365670919 4879.8079786139 5500.063016597521 5793.841171088748 5940.817933247643 5460.118071764108 5228.808624811337 5718.105090883804 5648.051703282205 5347.1839757949565 0.9997433022446487 0.9125939935306653 1.0285905705684713 1.0835312937268793 1.1110180536409227 1.0211202936873631 0.9778621136808705 1.069367561835892 1.0562665748642994 1.0 12.38456359977545 -5.418133915666202 5.989316529199513 1.047986359608973 0.9572115827813046 0.41370340853529 0.04187535495251891 0.21430607539682084 10.270368176675023 0.011462004616206457 0.02417891131981536 3.818265156334442e-06 5.418133915666202 -0.09077477682766832 QLHDDYFYHDEL ddPTM_A459_Selumetinib_30min_R2 1 QLHDDYFYHDEL 12 0 A8MXP8;Q14257;Q14257-2 A8MXP8 RCN2 Reticulocalbin-2 0 144.1 0.0049933 0.0 11351.0 10588.0 12067.0 14591.0 13904.0 9898.6 10225.0 11932.0 11049.0 10395.0 False True 10720.156861653242 11400.065554214068 11290.622357556202 12603.68062912106 12157.255216662903 11262.04229945574 10700.482760453118 11966.72014455107 13259.10873485423 10094.869340546446 1.0619411207825449 1.1292930269463965 1.1184515595666966 1.2485234037153778 1.204300403159534 1.115620412660647 1.0599921999459867 1.1854259565783838 1.313450257508385 1.0 13.301334617314865 -4.8419824196808126 1.683927413584745 1.163038745604082 1.0375861069471537 0.09756251460744392 0.08559792279733994 2.004496797436222 6.231865954605992 0.024092972793771403 0.3971342420742936 1.438856822261415e-05 4.8419824196808126 -0.12545263865692835 QLHLEGASLELS(ph)DDDTESK ddPTM_A459_Selumetinib_30min_R1 8 QLHLEGASLELSDDDTESK 19 0 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 1 QLHLEGASLELS(1)DDDTESK;QLHLEGASLELS(1)DDDTESK;QLHLEGASLELS(0.978)DDDT(0.019)ES(0.003)K;QLHLEGASLELS(0.98)DDDT(0.014)ES(0.006)K;QLHLEGASLELS(1)DDDTESK;QLHLEGASLELS(0.98)DDDT(0.015)ES(0.005)K;QLHLEGASLELS(0.999)DDDT(0.001)ESK;QLHLEGASLELS(0.959)DDDT(0.015)ES(0.026)K 247.02 1.0973999999999999e-37 82815000.0 29019.07 34367.34 25647.41 27388.589999999997 27892.039999999997 30027.15 36339.73 33759.62 14452.29 31253.789999999997 True False 29695.157869719176 30343.595855857104 22164.632593138824 22605.686904008668 25369.209906739612 29725.104133470828 33598.594908815554 32864.20521089954 24524.48057650175 35265.518384194766 0.842045125955894 0.8604324350285587 0.6285072106886291 0.6410138838095186 0.7193772009915934 0.8428942915182829 0.9527321998440752 0.9319076173180134 0.6954237935573092 1.0 15.105970626260275 -6.884216039600171 4.281574613330435 0.8903152751860164 0.7338696545968685 0.34781131247517383 0.10176875759618305 0.27171395600935366 8.827400799428279 0.03894808850483746 0.03423946854068194 1.3055212955776954e-07 6.884216039600171 -0.1564456205891479 QLHLEGASLELS(ph)DDDTESK ddPTM_A459_Selumetinib_30min_R2 2 QLHLEGASLELSDDDTESK 19 0 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 1 QLHLEGASLELS(1)DDDTESK;QLHLEGASLELS(0.99)DDDT(0.009)ES(0.001)K 147.08 2.8399e-05 14657100.0 121687.0 93697.0 121648.0 139614.0 135053.0 113694.0 126429.0 133881.0 102918.0 113145.0 True False 114924.12369165683 100883.25861665967 113821.30012032793 120598.33235241617 118086.43475086136 129354.31648862669 132308.1990143107 134270.57154480746 123504.47576918507 109878.20986398526 1.0459227888215301 0.9181370786941273 1.0358860074369949 1.097563679838805 1.0747029360692788 1.177251764919999 1.2041350070964099 1.2219945311360345 1.1240124490749106 1.0 16.745545785764193 -5.974550285310939 1.2393783001909164 1.1584860502215164 0.9796713268894506 0.43419381126279055 0.06812226991657098 0.3763312356934537 1.173698547158295 0.02471373394563172 0.048550444946980194 1.0603511572253182e-06 5.974550285310939 -0.17881472333206583 QLHVLVPQS(ph)PPTDLPGLTR ddPTM_A459_Selumetinib_30min_R1 1 QLHVLVPQSPPTDLPGLTR 19 0 O95402 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 QLHVLVPQS(0.998)PPT(0.002)DLPGLTR 74.744 0.026692 0.0 2444.0 2941.7 3515.2 3780.6 3370.9 3111.9 3126.5 3124.5 1607.2 2696.2 True False 2500.9404448038385 2597.2843964407725 3037.855147611457 3120.3891806513284 3066.0026901807328 3080.5971113791325 2890.66558784041 3041.6281101936447 2727.3010147563887 3042.283533212002 0.8220602772560712 0.8537285785781428 0.9985443876114106 1.0256733623236174 1.0077964978312486 1.0125936908078648 0.9501631114534824 0.9997845621516857 0.8964651009621516 1.0 11.570938899557824 -5.208987356278481 4.63498131479451 0.9883617813128788 0.8316848798132974 0.7331118926315564 0.0359319780431326 0.1030896027140332 4.824525445540497 0.009422060309157385 0.02622892417875284 6.180343928630074e-06 5.208987356278481 -0.15667690149958136 QLHVLVPQS(ph)PPTDLPGLTR ddPTM_A459_Selumetinib_30min_R2 1 QLHVLVPQSPPTDLPGLTR 19 0 O95402 O95402 MED26 Mediator of RNA polymerase II transcription subunit 26 1 QLHVLVPQS(0.994)PPT(0.004)DLPGLT(0.002)R 71.656 0.0092764 3516600.0 20419.0 26128.0 20040.0 23843.0 18021.0 16305.0 14953.0 13713.0 19842.0 19593.0 True False 19284.19372373338 28131.933585238483 18750.64821790225 20595.542268530855 15757.040870215926 18550.865747946766 15648.344128807392 13752.902559690643 23810.954431801765 19027.2991812724 1.0135013666423993 1.4785037706732078 0.9854603135876245 1.082420687892583 0.8281280869186509 0.9749605328225163 0.8224154137550567 0.7227984607099112 1.2514101031867766 1.0 14.215783173199652 -5.428810328348979 7.806764835778562 0.9406236631140901 1.2460486705577283 0.3025092735987698 0.1742576008421064 0.3057923479311203 22.606703615430426 0.04372158318684753 0.09134076712779521 3.725543783093873e-06 5.428810328348979 0.3054250074436382 QLILPGNS(ph)GNLK ddPTM_A459_Selumetinib_30min_R2 2 QLILPGNSGNLK 12 0 Q9P270;D6RIF6 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 QLILPGNS(1)GNLK;QLILPGNS(1)GNLK 141.65 0.0035799 2820200.0 58316.0 54508.0 60563.0 62503.0 61820.0 52856.0 67610.0 63795.0 48789.0 59097.0 True False 55075.030177444285 58688.588329155675 56666.44251600865 53989.98357631101 54053.618922187925 60136.43422100425 70753.99896667349 63980.63288816921 58548.16327855939 57390.71605755393 0.9596505142436735 1.0226146729080743 0.9873799528687017 0.9407442054245757 0.9418530144837465 1.0478425493192451 1.2328474677980716 1.1148254854322888 1.0201678477028362 1.0 15.808529754411808 -6.981351617674457 7.2212002300655955 1.1070135440194988 0.9743810033920169 0.44795115786796924 0.06309428029262798 0.13769873563081533 32.632542858002765 0.022940366467373074 0.019826116253381418 1.0438747251059849e-07 6.981351617674457 -0.13263254062748187 QLLDS(ph)DEEQEEDEGR ddPTM_A459_Selumetinib_30min_R1 1 QLLDSDEEQEEDEGR 15 0 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 1 QLLDS(1)DEEQEEDEGR 138.98 0.00039539 10061000.0 2725.7 2946.8 2451.9 2826.7 2471.7 2414.6 2709.2 2785.2 1721.8 2446.6 True False 2789.2035067110564 2601.787286069846 2118.945447322637 2333.069908730654 2248.135171414079 2390.311316281389 2504.842862810567 2711.327448395373 2921.768844703554 2760.644941902118 1.010344888752431 0.942456324817049 0.7675544997331883 0.8451177017799111 0.8143514355254562 0.8658524970018184 0.9073397396351521 0.9821355174082023 1.0583645873309662 1.0 11.430789633473136 -7.777359053686811 2.323604746766216 1.0285742031280074 0.869130222095356 0.4915323701101776 0.06424302294618381 0.2712696005898505 2.9028561898614016 0.04696379129121887 0.01987357946522617 1.6697096083130597e-08 7.777359053686811 -0.15944398103265145 QLLDS(ph)DEEQEEDEGR ddPTM_A459_Selumetinib_30min_R2 2 QLLDSDEEQEEDEGR 15 0 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 1 QLLDS(1)DEEQEEDEGR;QLLDS(1)DEEQEEDEGR 240.34 4.1509e-20 74643000.0 98307.0 87758.0 130061.0 121807.0 134696.0 107273.0 104172.0 92815.0 97921.0 106674.0 True False 92843.49049410142 94488.75641355492 121693.01685970963 105216.67647120492 117774.28428248178 122048.88202266127 109016.20441290207 93085.07628364948 117507.9361413395 103594.0444476624 0.8962242085355365 0.912106066688924 1.174710549323047 1.0156633716947145 1.136882770727071 1.178145738718818 1.0523404602470081 0.8985562517609568 1.1343116949228356 1.0 16.660581540272148 -5.174775158739797 8.228193075168114 1.0732308406499593 0.9020217712313613 0.4010885994516876 0.0829516039262233 0.3296046701414014 28.409169467817648 0.02157142215369681 0.057613176006777046 6.686900195813909e-06 5.174775158739797 -0.17120906941859804 QLLGLQPISTVS(ph)PLHR ddPTM_A459_Selumetinib_30min_R2 1 QLLGLQPISTVSPLHR 16 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 QLLGLQPIS(0.005)T(0.08)VS(0.915)PLHR 88.54799999999999 0.0091653 4599100.0 18850.0 14371.0 19352.0 21230.0 21042.0 15814.0 16672.0 18576.0 18746.0 20872.0 True False 17802.39246252872 15473.20948995186 18106.913388864472 18338.437376207265 18398.515842133264 17992.234954800988 17447.28103494126 18630.05308457765 22495.723807003113 20269.371128031304 0.878290320409058 0.7633788632225178 0.8933140191914348 0.9047363759029664 0.907700378364933 0.8876562988142649 0.8607707128521978 0.9191233890238174 1.109838271000569 1.0 14.307013708386584 -8.101543333861597 4.510054121612042 1.0521836805768865 0.8718568763018157 0.710973045893736 0.0461828858161654 0.12401256445849254 4.075346665081223 0.03452054430831536 0.012322968227244714 7.915104738450932e-09 8.101543333861597 -0.18032680427507075 QLLHLCLQDGGS(ph)PPGPGDLAEER ddPTM_A459_Selumetinib_30min_R2 1 QLLHLCLQDGGSPPGPGDLAEER 23 0 Q96FS4;F6RY50 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 QLLHLCLQDGGS(1)PPGPGDLAEER 60.761 0.034118 0.0 6132.2 3717.2 4858.1 3623.9 5103.6 3199.5 3785.4 3474.0 3115.0 5034.9 True False 5791.396873141572 4002.2972873181425 4545.535135099344 3130.3185684238106 4462.440141237108 3640.2020828307686 3961.4286006278016 3484.108764848338 3738.0870403720623 4889.529354758758 1.184448737894388 0.8185444849457519 0.929646762561182 0.6402085643227017 0.912652285622136 0.7444892583143865 0.810186075838224 0.712565261819609 0.7645085588317312 1.0 12.255479888851209 QLLLQQQQQQQVSGLKS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QLLLQQQQQQQVSGLKSPK 19 1 Q9H334-3;Q9H334-4;A0A3B3IRY1;A0A087WVT2;A0A3B3IU08;A0A3B3IU15;G5E965;C9J0F0;A0A3B3IST6;A0A3B3IUB6;A0A3B3IRS5;A0A3B3IST0;Q9H334-6;Q9H334-7;Q9H334;Q9H334-8 Q9H334-3 FOXP1 Forkhead box protein P1 1 QLLLQQQQQQQVS(0.003)GLKS(0.997)PK;QLLLQQQQQQQVS(0.117)GLKS(0.883)PK 118.21 0.00024925 30311000.0 85843.0 66416.0 68440.0 85395.0 63596.0 46263.0 69427.0 59021.0 44501.0 57914.0 True False 81072.1897167561 71509.89363890073 64036.64491183785 73764.05368540826 55606.501924546414 52635.30831629932 72655.49306699065 59192.74133854746 53402.44346182892 56241.87234135707 1.441491656335563 1.27147071500172 1.1385937602356269 1.3115504625753076 0.9887028935851512 0.9358740405517103 1.291839870230706 1.0524674743984384 0.9495139695511134 1.0 15.779357003345162 -1.522878745378254 0.3682738062794324 1.0264690946214206 6.436098137537767 0.5527952773894228 0.11363348318285897 53.50104276636484 0.7405467718570731 0.09366970496902584 204.41925107795916 0.029999999993236173 1.522878745378254 5.409629042916347 QLLLTADDR ddPTM_A459_Selumetinib_30min_R2 2 QLLLTADDR 9 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 148.94 0.020481 26196000.0 130876.0 102442.0 126851.0 125238.0 145973.0 117170.0 132198.0 165560.0 131076.0 104267.0 False True 123602.43585813839 110298.97199705303 118689.54476492619 108180.36835239982 127634.56672482271 133309.1039366404 138345.4689453675 166041.75219006673 157294.86256944097 101256.54079179958 1.2206859417831162 1.0893021935624505 1.1721666949789624 1.0683790647641893 1.26050688406649 1.3165480757509411 1.366286739242149 1.6398126075773851 1.5534291546939727 1.0 16.627655578119104 -6.834788329841764 1.6328740544697569 1.4424667689414967 1.1384647379532942 0.297834582978703 0.16480447237142895 0.3796614574015398 2.0920681675263926 0.07129319716560042 0.06120389964746049 1.4628899965676178e-07 6.834788329841764 -0.30400203098820255 QLLTLS(ph)SELSQAR ddPTM_A459_Selumetinib_30min_R2 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 1 QLLT(0.198)LS(0.591)S(0.198)ELS(0.013)QAR 78.508 0.040959 3682500.0 24907.0 29963.0 22826.0 31379.0 26661.0 20618.0 21496.0 18000.0 17378.0 24158.0 True False 23522.768650620852 32261.065753769923 21357.4000110697 27105.126068205747 23311.6068276359 23457.942348430923 22495.60659351592 18052.377019939584 20854.08558188947 23460.49576997797 1.0026543718962058 1.3751229330393735 0.9103558688815278 1.1553518021938716 0.9936536318839178 0.9998911608018823 0.9588717482391483 0.7694797755740921 0.8889021692617476 1.0 14.517945880440648 -6.634053740074807 0.8560438262210641 0.8779497357798001 1.1408505444893806 0.3360460207535042 0.12618456231314384 0.6162375716765933 0.9939851444882287 0.07343161921502812 0.07909489833227258 2.3224493961441606e-07 6.634053740074807 0.26290080870958055 QLLTLSS(ph)ELSQAR ddPTM_A459_Selumetinib_30min_R2 2 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 1 QLLT(0.031)LS(0.341)S(0.627)ELS(0.001)QAR;QLLT(0.009)LS(0.304)S(0.687)ELS(0.001)QAR 125.47 0.0021254 5650400.0 31115.7 28568.6 32127.6 34458.9 30125.6 23400.2 28898.3 24130.8 24180.5 25440.7 True False 29386.413960016187 30759.7197574726 30060.54519388602 29765.538375081887 26340.952801718915 26623.36514413393 30242.128210895116 24201.016632930994 29017.2756596201 24706.16088812315 1.189436679097437 1.2450222394633375 1.2167226357024514 1.2047820181317972 1.0661694028869393 1.0776002497794963 1.2240723416252517 0.9795539154189272 1.1744955353856457 1.0 14.592583225992227 -1.5228909734199279 0.1040311121307043 0.9335831889046581 1.8524134705702122 0.42271042175725093 0.07064606078499223 110.17217552847633 0.8105183019769038 0.7726584649408514 14.471452319720902 0.029999155321933504 1.5228909734199279 0.9188302816655541 QLMEQDASS(ph)SPSAQVIGLK ddPTM_A459_Selumetinib_30min_R2 1 QLMEQDASSSPSAQVIGLK 19 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 QLMEQDAS(0.013)S(0.464)S(0.464)PS(0.059)AQVIGLK 194.27 3.2651e-15 6865800.0 19858.0 17146.0 18489.0 23794.0 21631.0 20857.0 20077.0 20752.0 16654.0 17687.0 True False 18754.371857872447 18461.0430669205 17299.437869301128 20553.21615306057 18913.520396406435 23729.862429004945 21010.620281820764 20812.384884321462 19985.26535163927 17176.33035365512 1.0918730294379508 1.0747955288943307 1.0071672768927509 1.1966011208375977 1.1011386021916865 1.3815443660208382 1.2232310306811085 1.2116898345456304 1.1635352220264212 1.0 14.068134223587972 -5.776129912008198 24.28143559676251 1.197951059709974 1.0596303193259373 0.2593828633211407 0.09396799181560624 193.23186372063688 319385.44306390587 0.02606443081182809 0.03886261524490165 1.6744419195097162e-06 5.776129912008198 -0.13832074038403674 QLMEQDASSS(ph)PSAQVIGLK ddPTM_A459_Selumetinib_30min_R2 1 QLMEQDASSSPSAQVIGLK 19 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7;Q9H4L5-2;Q9H4L5-6;Q9H4L5-4;Q9H4L5-8 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 QLMEQDAS(0.091)S(0.288)S(0.609)PS(0.012)AQVIGLK 149.24 3.2433e-05 7478100.0 47844.0 42138.0 43159.0 58165.0 52443.0 52025.0 59484.0 53561.0 44528.0 49742.0 True False 45185.02201470684 45369.84910497468 40382.19692796621 50242.8266597784 45854.64149363151 59190.971514071185 62250.12386530991 53716.853642499154 53434.84421627195 48305.819214763 0.9353950051818519 0.9392211920320556 0.8359696116203074 1.0400988426757376 0.9492570923963882 1.2253383231306738 1.2886671808328491 1.112016202513391 1.1061782014027295 1.0 15.55990937495796 -6.74956372411474 24.735362751413252 1.16233018580636 0.9397285342588161 0.5908374985343905 0.08539124295825243 132.30007087361258 275562.2552897672 0.028771513173808896 0.028547381574966096 1.7800667001536063e-07 6.74956372411474 -0.22260165154754386 QLPALDGSLMGPES(ph)PPAQEEEAPVSPHK ddPTM_A459_Selumetinib_30min_R2 1 QLPALDGSLMGPESPPAQEEEAPVSPHK 28 0 A0A494C108;Q8N9T8 A0A494C108 KRI1 Protein KRI1 homolog 1 QLPALDGSLMGPES(1)PPAQEEEAPVSPHK 117.0 2.757e-12 10925000.0 28086.0 16295.0 24807.0 33888.0 35047.0 23865.0 26579.0 30085.0 23592.0 24139.0 True False 26525.09255716613 17544.774103316784 23210.944627819394 29272.39593993933 30644.082535844707 27152.187125099637 27814.97616528934 30172.54236916012 28311.05921555624 23442.04434934591 1.1315178899022194 0.7484319132689605 0.9901416566711272 1.2487134442588026 1.3072273936167924 1.1582687380188856 1.1865422550514646 1.28711224667579 1.2077043620278873 1.0 14.516810770301676 -5.673649668212391 4.895815207074659 1.2133524393515984 0.9252572501688264 0.46734742709127575 0.11816939664399383 0.15042283974589254 6.1688418735095985 0.03057579293371199 0.05376342574992616 2.1200706403907173e-06 5.673649668212391 -0.288095189182772 QLPLEPES(ph)PSGQVGPR ddPTM_A459_Selumetinib_30min_R2 4 QLPLEPESPSGQVGPR 16 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 QLPLEPES(0.915)PS(0.085)GQVGPR;QLPLEPES(0.854)PS(0.146)GQVGPR;QLPLEPES(0.996)PS(0.004)GQVGPR;QLPLEPES(0.983)PS(0.017)GQVGPR 205.78 8.582900000000001e-08 71726000.0 179285.0 150906.0 179514.0 211630.0 213619.0 191036.0 216856.0 237666.0 198680.0 167007.0 True False 169321.0574347196 162480.0049607315 167964.26468006463 182805.62891788688 186782.27144190963 217349.47494785363 226940.2336920117 238357.56871227565 238421.551583024 162185.07397370288 1.0439990147439449 1.0018184841539515 1.035633308076789 1.1271421249746292 1.1516612895721527 1.3401324155334742 1.3992670726827081 1.4696640256237363 1.47005853092056 1.0 17.30728152768515 -6.552269332704265 1.5582926820450342 1.377691313327242 1.0340056369124762 0.5120965114078839 0.12938552707720075 0.27035499304271116 1.344128844384813 0.050067565619983205 0.053848554641937545 2.8036943554768375e-07 6.552269332704265 -0.3436856764147658 QLPLEPES(ph)PSGQVGPRPAPPQEES(ph)PSSEAK ddPTM_A459_Selumetinib_30min_R1 2 QLPLEPESPSGQVGPRPAPPQEESPSSEAK 30 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 QLPLEPES(0.939)PS(0.063)GQVGPRPAPPQEES(0.876)PS(0.094)S(0.028)EAK;QLPLEPES(0.925)PS(0.084)GQVGPRPAPPQEES(0.926)PS(0.049)S(0.016)EAK 80.542 4.063e-05 18400800.0 2134.1 2523.1 3069.0 3134.2 2907.2 2882.4 2245.25 2171.25 1447.27 1807.2 True False 2183.820377764268 2227.6942790426333 2652.246656810299 2586.8708062205455 2644.2442733078465 2853.4056730098023 2075.8889848388553 2113.661396786031 2455.9114855814328 2039.171723618698 1.070935003889166 1.0924505539383336 1.3006489968896013 1.2685889943736102 1.296724666530483 1.3992964103808634 1.0180059682050706 1.0365293772488884 1.2043671737577804 1.0 10.993767557996591 -7.288470070662828 24.996661756462956 1.0677697301628966 1.2383794376019706 0.39569512142577823 0.10494067233290597 880.752675495659 814473.0571716691 0.04734364492981861 0.03192875251240913 5.146712742830124e-08 7.288470070662828 0.170609707439074 QLPLEPES(ph)PSGQVGPRPAPPQEES(ph)PSSEAK ddPTM_A459_Selumetinib_30min_R2 2 QLPLEPESPSGQVGPRPAPPQEESPSSEAK 30 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 QLPLEPES(0.943)PS(0.188)GQVGPRPAPPQEES(0.602)PS(0.199)S(0.068)EAK;QLPLEPES(0.893)PS(0.186)GQVGPRPAPPQEES(0.627)PS(0.264)S(0.03)EAK 63.291 0.0019193 8191700.0 43655.0 51785.0 46656.0 58667.0 52293.0 32367.0 33206.6 28331.0 22775.0 57872.0 True False 41228.82986481124 55756.742984980636 43654.20375521191 50676.4533937801 45723.48583464853 36825.26045162789 34750.77269762962 28413.438519550473 27330.63638666892 56201.08499048621 0.7335949096319138 0.9920937112587631 0.776750195527395 0.9016988444681926 0.8135694505255309 0.6552410946845904 0.6183292138134392 0.5055674374322192 0.48630086752409646 1.0 15.778310362224907 -6.764923698992413 2.9358598404321845 0.6134035009541547 0.8567310969348585 0.2803238371799395 0.1480877729872145 0.27539116582304446 4.884388780895182 0.05184893508378144 0.04808661920210181 1.718210232245541e-07 6.764923698992413 0.24332759598070375 QLPLEPES(ph)PSGQVGPRPAPPQEESPSSEAK ddPTM_A459_Selumetinib_30min_R1 1 QLPLEPESPSGQVGPRPAPPQEESPSSEAK 30 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 QLPLEPES(0.5)PS(0.5)GQVGPRPAPPQEESPSSEAK 92.363 3.436e-07 31302000.0 604.92 730.48 979.85 1111.5 770.12 862.18 828.25 610.32 395.18 471.64 True False 619.0134590305798 644.9550620090612 846.7917519307821 917.3973904390708 700.462781975729 853.5072519968054 765.7744356720993 594.1323310012436 670.591597194767 532.1795881626398 1.1631664813897422 1.2119124377464023 1.5911766831462792 1.7238492622507429 1.3162150476197145 1.6037955438004594 1.438939885529902 1.116413226318012 1.2600851519127167 1.0 9.055769366385759 -7.757647364018058 23.951652197523167 1.1411868244925936 1.445927561410834 0.39302202182715995 0.1759361889210055 62.80707617612163 396725.0966938121 0.09206541120207778 0.050470607101618846 1.747240291405669e-08 7.757647364018058 0.30474073691824044 QLPLEPESPS(ph)GQVGPRPAPPQEESPSSEAK ddPTM_A459_Selumetinib_30min_R1 1 QLPLEPESPSGQVGPRPAPPQEESPSSEAK 30 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 QLPLEPES(0.177)PS(0.802)GQVGPRPAPPQEES(0.014)PS(0.005)S(0.002)EAK 56.46 0.0025862 35672000.0 492.88 721.03 1049.8 1156.4 931.85 931.31 853.89 759.17 436.78 662.62 True False 504.3631450224697 636.6114724022466 907.2429261386285 954.4564483164562 847.5643320314801 921.9418669618229 789.4803898292168 739.0343454683016 741.1837588509807 747.673731465373 0.6745765215449839 0.851456251050235 1.2134208919718423 1.2765681180824795 1.1336018591563068 1.2330804576414638 1.0559156442234592 0.9884449785601817 0.9913197798166955 1.0 9.546265036512112 -5.0594004532351455 3.748501262046357 1.1191938559836094 0.6985776225521722 0.6726981132191905 0.10040545369001988 0.1347037013405648 3.687108048649194 0.028839171671099884 0.10270457582752078 8.721667919984632e-06 5.0594004532351455 -0.4206162334314373 QLPLEPESPSGQVGPRPAPPQEES(ph)PSSEAK ddPTM_A459_Selumetinib_30min_R2 2 QLPLEPESPSGQVGPRPAPPQEESPSSEAK 30 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 QLPLEPESPS(0.001)GQVGPRPAPPQEES(0.449)PS(0.449)S(0.101)EAK;QLPLEPESPS(0.001)GQVGPRPAPPQEES(0.752)PS(0.202)S(0.045)EAK 103.78 4.385e-09 29125000.0 64023.0 70898.0 73250.0 73013.0 65853.0 41586.0 36940.0 34785.0 28980.1 66737.0 True False 60464.8579643754 76335.64862699911 68537.17474856967 63068.503445549686 57579.95740671039 47314.09401987818 38657.78319522137 34886.21859103325 34776.92977164892 64810.129406450076 0.9329538224677233 1.1778351520989556 1.0575071424212998 0.9731272568524287 0.8884407103340837 0.7300416532599819 0.5964774881528634 0.5382834274600489 0.5365971352031867 1.0 15.983931694239347 -6.592680463852248 1.5050894481583967 0.6290735171903299 1.0602669858692506 0.5959686539659055 0.1378219737391155 0.23675000611904518 1.1061167125327445 0.055262885640508776 0.057630172646913974 2.5545801671653295e-07 6.592680463852248 0.4311934686789207 QLPPPS(ph)PQLPK ddPTM_A459_Selumetinib_30min_R1 1 QLPPPSPQLPK 11 0 Q14678 Q14678 KANK1 KN motif and ankyrin repeat domain-containing protein 1 1 QLPPPS(1)PQLPK 93.766 0.023767 0.0 1034.8 1055.1 1495.4 1506.9 1377.4 1154.4 1118.2 1392.6 627.07 1007.7 True False 1058.90882662971 931.5684014973174 1292.3328936442233 1243.7482030163164 1252.8144131997221 1142.787784111337 1033.853273732015 1355.6637241976864 1064.0919906192694 1137.048110829217 0.9312788232482773 0.8192867061869097 1.1365683486354519 1.0938395580370703 1.1018130202829148 1.0050478719655356 0.909243209575411 1.1922659307784604 0.9358372618404487 1.0 10.151077583559161 -5.255516470774066 24.98668480038437 1.0509305431530522 0.8752827579169031 0.3817593273800831 0.08719619873417513 460.99099384747075 1944745.3327639434 0.021805454711902424 0.05453925495886981 5.5524355890903376e-06 5.255516470774066 -0.1756477852361491 QLPPPS(ph)PQLPK ddPTM_A459_Selumetinib_30min_R2 1 QLPPPSPQLPK 11 0 Q14678 Q14678 KANK1 KN motif and ankyrin repeat domain-containing protein 1 1 QLPPPS(1)PQLPK 115.24 0.006234600000000001 3596300.0 38843.0 34142.0 33129.0 36297.0 39816.0 26463.0 38365.0 41238.0 29595.0 31480.0 True False 36684.26156084896 36760.581616167015 30997.516208127912 31353.28598418253 34813.95812044377 30108.03804280375 40149.0485188053 41357.995752681585 35514.82695339041 30571.090605137295 1.1999657465502516 1.2024622245563465 1.0139486552343984 1.025586113009452 1.1387869203002356 0.9848532534113869 1.3133011523003528 1.3528465924513537 1.161712789776049 1.0 14.899880399963982 -7.2695846459564875 24.977572715585705 1.236369012988795 1.0944360288130623 0.17327952220696785 0.11354715026145158 864.3426023100021 2650508.0039834566 0.04682259431394142 0.03216026673306876 5.375456528353617e-08 7.2695846459564875 -0.14193298417573263 QLPS(ph)PEPCEIQK ddPTM_A459_Selumetinib_30min_R1 1 QLPSPEPCEIQK 12 0 A0A590UK32;A0A590UJW2;A0A590UJD8;Q5VVJ2-2;Q5VVJ2 A0A590UK32 MYSM1 Histone H2A deubiquitinase MYSM1 1 QLPS(1)PEPCEIQK 102.9 0.011186 9700600.0 1872.4 1980.6 2459.3 2541.5 2242.9 1828.0 2051.4 2008.4 911.44 1810.1 True False 1916.0232769438237 1748.710431244041 2125.340567967928 2097.674734863606 2040.0300910161563 1809.6119796912026 1896.6612464083858 1955.1307077973822 1546.6471110562234 2042.4439668670902 0.938103227322714 0.8561852660890337 1.0405869646588117 1.0270415095309735 0.9988181434153924 0.8860032436860291 0.9286233929431509 0.957250597575199 0.7572531418957991 1.0 10.996080784168006 -6.765385462525958 24.993246872935423 0.9045790651565413 0.972556616886025 0.1603767869988496 0.07584411450969898 200.2166381376122 1268099.1705373991 0.026772844322480744 0.024486231157504527 1.7163843163845923e-07 6.765385462525958 0.06797755172948372 QLQEERPELSES(ph)ELTR ddPTM_A459_Selumetinib_30min_R2 1 QLQEERPELSESELTR 16 1 E9PLT2;E9PKP7;P17480-2;P17480 E9PLT2;E9PKP7 UBTF Nucleolar transcription factor 1 1 QLQEERPELS(0.437)ES(0.544)ELT(0.018)R 57.00899999999999 0.04714 3941100.0 5376.0 5342.6 4965.5 6327.8 5870.1 5167.0 6231.2 4628.7 5284.2 6567.3 True False 5077.2234418331245 5752.360240833404 4646.0251360276225 5465.942723936147 5132.645558640167 5878.707348644033 6520.96314688856 4642.1687506774615 6341.187652884126 6377.6849851054085 0.7960919132397709 0.9019511396796169 0.7284814390924067 0.8570418163803064 0.8047819186157775 0.921761950045087 1.0224655438639203 0.7278767705709656 0.9942773385160102 1.0 12.638817124546092 -6.766622906259593 24.56320829003706 0.921842970402945 0.8195843875093579 0.3000905128367677 0.08738487000744072 148.8368477213812 705288.4438954173 0.029259442324035753 0.026590031263536044 1.7115007498165861e-07 6.766622906259593 -0.10225858289358714 QLQPGEPGAETEDDHS(ph)VTEGPADEGIRPR ddPTM_A459_Selumetinib_30min_R2 1 QLQPGEPGAETEDDHSVTEGPADEGIRPR 29 1 Q8IVF2 Q8IVF2 AHNAK2 Protein AHNAK2 1 QLQPGEPGAET(0.012)EDDHS(0.494)VT(0.494)EGPADEGIRPR 52.97 0.0052612 2667200.0 12806.0 9140.8 12457.0 15267.0 14415.0 11371.0 18957.0 16696.0 13199.0 10262.0 True False 12094.293786479726 9841.869967695498 11655.530182156097 13187.608262956017 12604.058828264942 12937.252034339313 19838.538062582873 16744.582595828397 15839.168810873476 9965.709396121953 1.2135908549757721 0.9875734457524273 1.1695635221604717 1.3232984967520558 1.2647427621328868 1.298176729834577 1.9906799680816325 1.6802198348613666 1.5893669162214499 1.0 13.28275678976055 -7.029175935494279 17.298809283431936 1.6249962799113296 1.1959803361898784 0.33438110767171103 0.24373009653777655 15.812489161133986 9374.588755665292 0.08973380240218551 0.06994452634607128 9.350268120238297e-08 7.029175935494279 -0.42901594372145113 QLS(ph)ENRK ddPTM_A459_Selumetinib_30min_R2 1 QLSENRK 7 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 QLS(1)ENRK 68.485 0.03714 2543500.0 27386.0 23227.0 25351.0 29016.0 26653.0 18738.0 23424.0 25416.0 19091.0 29396.0 True False 25863.99575484413 25008.43621342368 23719.944260081837 25063.970744608105 23304.611859156816 21318.98941337174 24513.262413775454 25489.9563521547 22909.733447108523 28547.261100019565 0.9060062071883458 0.8760362728250151 0.8309008761637585 0.8779816269165985 0.8163519357428248 0.7467963157193083 0.8586905177309165 0.8929037452260956 0.8025194909886757 1.0 14.80106471578671 -10.96924503986363 5.426893594153738 1.0001535664571475 0.8448300663479152 0.5094323482524528 0.04552405026342788 8.857673953755636e-05 9.03628155425918e-06 0.046158942403139586 0.011184160759656822 1.0733836114378539e-11 10.96924503986363 -0.15532350010923224 QLS(ph)ESESSLEMDDER ddPTM_A459_Selumetinib_30min_R2 1 QLSESESSLEMDDER 15 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 QLS(0.821)ES(0.166)ES(0.007)S(0.007)LEMDDER 92.427 0.013515 16384000.0 30541.0 31199.0 32872.0 31543.0 37087.0 23518.0 25083.0 32380.0 21428.0 21950.0 True False 28843.653485309813 33591.86297940351 30757.05130832746 27246.788985289946 32427.79949801331 26757.391024852004 26249.409201021586 32474.22043920244 25714.19874834433 21316.24646705095 1.3531300423784347 1.5758807739123903 1.4428924602588638 1.2782170175882503 1.521271559143293 1.2552580993192946 1.2314273641748301 1.5234492850042172 1.206319263951625 1.0 14.379665798879216 -13.519973739867982 0.14735741642113234 3.2992297702628495e-11 1.519108967081448 0.5252178485296479 0.11716877464734843 77.24723723363007 0.8949185883127435 23.55473368950722 0.6458379440170537 3.0201343308929004e-14 13.519973739867982 1.5191089670484557 QLS(ph)LEGSGLGVEDLKDNTPSGK ddPTM_A459_Selumetinib_30min_R2 1 QLSLEGSGLGVEDLKDNTPSGK 22 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 QLS(0.99)LEGS(0.01)GLGVEDLKDNTPSGK 54.605 0.014935 4659800.0 9780.4 9511.0 11224.0 10779.0 10150.0 8396.5 8539.2 10165.0 7030.1 12532.0 True False 9236.844522043282 10240.463117314883 10501.860059767201 9310.881605187857 8874.866257848713 9553.04165916191 8936.2897201038 10194.578467093663 8436.316437405978 12170.16859795364 0.7589742449086874 0.8414397084882432 0.8629182065343813 0.7650577336088377 0.7292311677046925 0.7849555724945514 0.7342782187591385 0.8376694525668146 0.6931963488841484 1.0 13.571061533940187 -10.893932644328796 4.259814034221498 1.0004568802603715 0.7817268241755289 0.6203452313633879 0.051901848922343605 76277030.85306552 226.06994654829722 341827.6355727216 0.012652402373319415 1.2766367898212361e-11 10.893932644328796 -0.21873005608484264 QLS(ph)LPLTQSK ddPTM_A459_Selumetinib_30min_R1 2 QLSLPLTQSK 10 0 Q9C0I1-3;Q9C0I1-2;Q9C0I1 Q9C0I1-3 MTMR12 Myotubularin-related protein 12 1 QLS(0.966)LPLT(0.034)QSK;QLS(0.909)LPLT(0.09)QSK 117.2 0.0060978 69162000.0 6294.0 7105.4 7738.0 7763.5 6879.6 7044.1 6652.2 7209.8 4081.8999999999996 5169.6 True False 6440.63795400792 6273.496464789159 6687.222101791492 6407.75046394397 6257.34139469203 6973.242749531072 6150.4191982830525 7018.572683269053 6926.686169819624 5833.168516168228 1.1041405603414205 1.075486924027729 1.146413322923214 1.0985025456033253 1.0727174051886363 1.195446819374893 1.0543873679005633 1.2032178847251116 1.187465465916236 1.0 12.51006403786887 -6.713582288726422 24.999917343976023 1.1361982973529658 1.1006769904117544 0.041762751611197246 0.06276797599623196 341.54905702599757 178419.7044768967 0.019821348458067045 0.01982129110997066 1.9338274084844573e-07 6.713582288726422 -0.03552130694121147 QLS(ph)MSSADSADAK ddPTM_A459_Selumetinib_30min_R2 1 QLSMSSADSADAK 13 0 Q5JSZ5;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 QLS(0.629)MS(0.367)S(0.004)ADSADAK 126.07 0.0018377 0.0 20268.0 15912.0 20054.0 22197.0 19418.0 21365.0 19281.0 18313.0 16032.0 20646.0 True False 19141.585699232473 17132.39923485589 18763.747473144296 19173.73030803923 16978.537240877456 24307.83481784008 20177.60470457669 18366.287798119636 19238.847971507188 20049.89633524984 0.9546974896613076 0.8544881703320989 0.9358525929211735 0.9563007203348869 0.8468142157437188 1.21236710711089 1.0063695276619624 0.9160290652390934 0.9595485008909127 1.0 14.291307157027271 QLS(ph)MTLR ddPTM_A459_Selumetinib_30min_R1 2 QLSMTLR 7 0 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;E5RIU4;E5RJQ8;E5RGV7 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 QLS(0.823)MT(0.177)LR;QLS(0.997)MT(0.003)LR 102.06 0.019521 18071600.0 5469.0 6268.4 6728.7 6792.8 5921.3 5371.4 6035.8 5574.799999999999 2644.1 4803.299999999999 True False 5596.417059178471 5534.492813899902 5814.9794981034365 5606.56499664824 5385.7194604904225 5317.368592840986 5580.514746549539 5426.938194497529 4486.844582576761 5419.850343104079 1.0325777844214916 1.0211523314369164 1.0729040711432372 1.0344501493074854 0.9937026153024534 0.9810914058921414 1.0296436973854604 1.001307757769081 0.8278539624780556 1.0 12.404037300034135 -8.06090596170332 10.069444747835878 0.9138044473330547 1.0225407638831763 0.4810153498778291 0.04494295477463897 0.5025022839041455 80.81230535964221 0.028943114803205005 0.010947511506496956 8.691486066859231e-09 8.06090596170332 0.10873631655012161 QLS(ph)MTLR ddPTM_A459_Selumetinib_30min_R2 1 QLSMTLR 7 0 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;E5RIU4;E5RJQ8;E5RGV7 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 QLS(0.997)MT(0.003)LR 81.525 0.042863 9871500.0 16034.0 14639.0 18026.0 17837.0 22700.0 15052.0 18370.0 11337.0 12277.0 15557.0 True False 15142.894469187557 15761.764228196043 16866.226785224844 15407.569829458738 19848.223059425185 17125.276371548283 19224.241399464438 11369.988793058623 14732.743048041038 15107.82898805975 1.002321013903157 1.0432845275554232 1.1163898399005454 1.0198401002312036 1.3137706996228204 1.133536551484862 1.2724688249157463 0.7525891908125731 0.9751727438591504 1.0 13.883008738053988 -7.761289468894685 24.999999910899056 0.8979107417234629 1.128140625398029 0.4411678275523262 0.11301620150374808 3.617585206894092 603659.2084537382 0.05761192046480838 0.030537097793756605 1.7326487560324704e-08 7.761289468894685 0.2302298836745662 QLS(ph)PQSK ddPTM_A459_Selumetinib_30min_R2 3 QLSPQSK 7 0 E7ERS3;Q86VM9;H3BRH3 E7ERS3;H3BRH3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 QLS(0.995)PQS(0.005)K;QLS(0.716)PQS(0.284)K;QLS(0.813)PQS(0.187)K 99.973 0.020867 204450000.0 709800.0 516520.0 540890.0 649870.0 590790.0 567610.0 1047590.0 1828770.0 791850.0 1305480.0 True False 670352.1575545295 556135.4231264311 506089.7262765038 561356.5849117192 516569.6784703886 645793.1252494367 1096305.0107602042 1834091.4179308282 950242.1261375991 1267787.4003556138 0.5287575482817514 0.4386661540968425 0.39919132035430066 0.44278448007470256 0.40745765285685204 0.5093859783338216 0.8647388437940707 1.4466868951500593 0.7495279775387077 1.0 20.273881404574063 -7.349937394600032 3.2737293501912257 1.0842433561973686 0.44423085529085715 0.74074554835919 0.16489452546533492 0.11478934771429841 2.363846816401268 0.07019417098456579 0.04531054069880742 4.467479881353256e-08 7.349937394600032 -0.6400125009065114 QLS(ph)SGVSEIR ddPTM_A459_Selumetinib_30min_R1 4 QLSSGVSEIR 10 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 QLS(0.499)S(0.499)GVS(0.001)EIR;QLS(0.568)S(0.432)GVSEIR;QLS(0.498)S(0.498)GVS(0.004)EIR;QLS(0.498)S(0.498)GVS(0.004)EIR 164.22 0.0003791000000000001 1490070000.0 13163.5 14465.900000000001 15763.6 17566.5 17002.5 13359.599999999999 16101.900000000001 15676.3 7100.1900000000005 12064.199999999999 True False 13470.183938287777 12772.225702985545 13622.989703256697 14498.84053904448 15464.62687703518 13225.214553546262 14887.320719285939 15260.513600201199 12048.503852640104 13612.75758525935 0.9895264683824267 0.9382541063403655 1.0007516565202355 1.0650920982200278 1.136039247020834 0.9715308945093725 1.0936300471115974 1.1210449833269733 0.8850891362149057 1.0 13.732671727919387 -5.552842438378167 4.5823368147462205 1.047131036251088 0.9644294928012304 0.14414232035478292 0.07169665350458228 0.3115336306775835 15.616392131592383 0.01912351854303228 0.03582817944038225 2.7999969716023937e-06 5.552842438378167 -0.08270154344985758 QLS(ph)SGVSEIR ddPTM_A459_Selumetinib_30min_R2 1 QLSSGVSEIR 10 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 QLS(0.367)S(0.367)GVS(0.266)EIR 138.2 0.0016624000000000005 1325200000.0 78445.0 63860.0 100190.0 91084.0 100280.0 35887.0 70994.0 78297.0 57969.0 66555.0 True False 74085.34094021562 68757.85665773599 93743.88447862418 78678.20207133594 87681.92988542552 40830.108500249335 74295.36167194218 78524.8313072338 69564.41978919038 64633.3842193429 1.146239545322215 1.063813344886848 1.4503941826795037 1.2172997441125764 1.3566043453312608 0.6317185614432064 1.1494889609959142 1.2149268099709623 1.076292393310449 1.0 15.979991912997876 QLS(ph)TEQAVLQESLEK ddPTM_A459_Selumetinib_30min_R2 2 QLSTEQAVLQESLEK 15 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 QLS(0.748)T(0.252)EQAVLQESLEK;QLS(0.923)T(0.077)EQAVLQESLEK 94.61 0.011355 9079700.0 37058.0 33034.0 36559.0 38927.0 36156.0 19333.4 33207.0 37490.0 25987.0 28020.0 True False 34998.46471492783 35567.60157894855 34206.83374242955 33625.07544717948 31613.760041258924 21996.400358868676 34751.19129842217 37599.089693196394 31185.126137447452 27210.98979529693 1.2861885943221685 1.307104293027075 1.2570962688149538 1.2357167343097215 1.1618011795632277 0.8083645807941345 1.2771013314785216 1.3817611919319053 1.1460489446377067 1.0 14.731901814887314 -6.104032438124398 2.9495776195259706 1.140202502517202 1.282971339350615 0.19286050177034664 0.14437257060365044 0.5479742338538633 9.185444425603695 0.04848834177313233 0.06702971200238396 7.869870062270316e-07 6.104032438124398 0.14276883683341302 QLS(ph)VSDR ddPTM_A459_Selumetinib_30min_R1 1 QLSVSDR 7 0 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 QLS(0.999)VS(0.001)DR 84.81700000000002 0.037033 5938000.0 2574.3 3222.5 2634.8 3168.4 3013.4 3068.2 2930.3 2641.5 1499.4 2123.1 True False 2634.276181284172 2845.208201900394 2277.0086319204215 2615.0984182340558 2740.83850205898 3037.336693702705 2709.2651118019367 2571.438839198756 2544.3722881568738 2395.620565745273 1.0996216257914173 1.1876706364036642 0.9504880132017269 1.0916162833242766 1.1441037621942065 1.267870520537878 1.130924133204329 1.0733915361921207 1.0620931897724482 1.0 11.226183707285282 -8.331164100121892 1.719257395579594 1.00632748280053 1.1236591576192243 0.20577387049143137 0.07631617804860605 0.6061506279990997 3.534015062381261 0.07745286046461279 0.022785759114689188 4.664830842792921e-09 8.331164100121892 0.11733167481869433 QLSDVSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QLSDVSSPR 9 0 Q9P0K7-4 Q9P0K7-4 RAI14 Ankycorbin 1 QLS(0.001)DVS(0.094)S(0.905)PR 92.866 0.025325 6807500.0 65692.0 55142.0 70457.0 71517.0 82711.0 53279.0 74102.0 76806.0 81815.0 111720.0 True False 62041.101625911746 59371.21409052434 65923.87332778148 61776.26122629377 72320.10473427821 60617.69863139256 77547.88983032739 77029.49274408228 98180.28610209964 108494.35331657989 0.5718371484724151 0.5472286093754831 0.6076249252845413 0.5693960960902216 0.6665794349983595 0.558717544078205 0.7147642938065853 0.709986191809586 0.9049345251693935 1.0 16.727260432736443 -8.166447922737978 0.9046715956089506 1.0073287580409978 0.5822743003726699 0.9252638053735476 0.040227714696202864 0.12492597810908687 0.20755536146873216 0.03553083311359631 0.013144480267728449 6.816353063021855e-09 8.166447922737978 -0.42505445766832783 QLSES(ph)ESSLEMDDER ddPTM_A459_Selumetinib_30min_R2 3 QLSESESSLEMDDER 15 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 QLSES(0.855)ES(0.073)S(0.073)LEMDDER;QLS(0.269)ES(0.73)ES(0.001)S(0.001)LEMDDER;QLSES(0.541)ES(0.123)S(0.336)LEMDDER 248.1 6.5607999999999986e-28 29383600.0 43385.0 35661.0 43830.0 43679.0 55947.0 37253.0 42771.0 55606.0 45117.0 38731.0 True False 40973.83538391559 38396.08403181222 41010.025518495786 37729.84484952227 48918.437687474056 42384.26260093593 44759.936249128674 55767.804253931135 54141.66067430699 37612.73539477677 1.0893606900391928 1.020826686195874 1.0903228677218406 1.0031135585730828 1.300581762374754 1.1268593511234435 1.1900207676824384 1.482684087413529 1.43945023157836 1.0 15.198933610069561 -6.710625649105309 1.0028260717078499 1.317129611905495 1.0493431310905206 0.2918868454468041 0.1411496300516937 0.5883574664755662 1.2744070247568806 0.07861298407003488 0.07542611996647205 1.947037655879328e-07 6.710625649105309 -0.26778648081497436 QLSES(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 QLSESFK 7 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 QLS(0.001)ES(0.999)FK 94.363 0.024494 30679000.0 4038.8 4813.2 4675.9 4710.1 3572.7 3824.5 4442.3 4599.9 3026.5 4159.8 True False 4132.8961818632315 4249.668306404024 4040.938462880178 3887.569454527275 3249.5499158114158 3786.029002368165 4107.213734483749 4477.895709419025 5135.749453185797 4693.750849883275 0.8805103453597264 0.9053885564696529 0.8609188242236311 0.8282436752312816 0.6923141043782131 0.8066105601796731 0.875038719744975 0.954012228733952 1.0941674616822736 1.0 12.19652554851345 -7.862569544693698 2.365109332554855 1.0447353332608533 0.8290347875498543 0.6828450832982047 0.05882984022287405 0.1912938948438472 2.0848225161721037 0.047050329579877155 0.018456195313935685 1.3722412028954671e-08 7.862569544693698 -0.21570054571099906 QLSES(ph)FK ddPTM_A459_Selumetinib_30min_R2 4 QLSESFK 7 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 QLS(0.004)ES(0.996)FK;QLS(0.027)ES(0.973)FK;QLS(0.002)ES(0.998)FK;QLS(0.003)ES(0.997)FK 107.55 0.016646 114057700.0 752873.0 695457.0 715702.0 708223.0 674901.0 653516.0 756051.0 695762.0 512162.0 664327.0 True False 711031.3326494105 748796.3156532929 669654.5125174191 611761.805647179 590113.9026885078 743531.8969724125 791208.8695866358 697786.5522303998 614608.7110019366 645146.153381164 1.1021244239354866 1.1606615210040485 1.037988847965393 0.9482530469118974 0.9146980100489848 1.1525014805957008 1.226402522033136 1.0815945326083887 0.9526658537461894 1.0 19.29926650454258 -9.724607033397712 0.006820179096895334 4.28784873240812e-07 2.077309767427761 0.043186089103500525 0.09672085401737322 44924.86153242913 82.87676990155863 12974.963930857313 12268.269178716511 1.885354260060634e-10 9.724607033397712 2.0773093386428876 QLSFIS(ph)PPTPQPK ddPTM_A459_Selumetinib_30min_R2 2 QLSFISPPTPQPK 13 0 O43395;O43395-3 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 QLS(0.002)FIS(0.996)PPT(0.001)PQPK;QLSFIS(0.5)PPT(0.5)PQPK 122.34 0.0019529 0.0 56455.0 63122.0 61837.0 62380.0 60007.0 56316.0 51168.0 57599.0 46868.0 53657.0 True False 53317.45710727107 67963.25443078004 57858.47474303496 53883.73638849788 52468.384190613564 64073.01781425143 53547.41338746852 57766.60355397225 56242.9096013348 52107.782992371394 1.0232148451811272 1.3042822113681156 1.110361474244749 1.034082305831098 1.0069202943885553 1.2296247150570914 1.027627934109342 1.1085983750724784 1.0793571779779767 1.0 15.669211253893804 -9.134387808778241 0.015082477488536753 4.990892757095021e-07 2.113721584839031 0.11383024379756934 0.09063907242878906 2345.6016592381684 13.745844343505286 1002.0513526696643 922.4536766239404 7.33858267418687e-10 9.134387808778241 2.1137210857497553 QLSLEGS(ph)GLGVEDLKDNTPSGK ddPTM_A459_Selumetinib_30min_R1 1 QLSLEGSGLGVEDLKDNTPSGK 22 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 QLS(0.033)LEGS(0.966)GLGVEDLKDNT(0.001)PSGK 93.062 0.00015983 65976000.0 5448.0 5248.5 7700.4 7447.2 6288.9 6182.0 6798.9 5734.0 3213.1 4871.6 True False 5574.927800037362 4634.003180038548 6654.727975269473 6146.686321257626 5720.0701053954745 6119.814692806897 6286.053499174204 5581.915693343054 5452.3960244610225 5496.9173134024195 1.0141916791152634 0.8430185349050202 1.2106290846042225 1.118206072751169 1.0405959884913987 1.1133175821811523 1.1435597701001863 1.0154629176854078 0.991900680617326 1.0 12.424407062665834 -5.25182348162719 24.99964359061059 1.083291380877771 0.928605114160682 0.3826621415188949 0.07637488581208471 672.1376335460654 1747431.9001200895 0.019450532187899924 0.04997188576703513 5.599851604163191e-06 5.25182348162719 -0.15468626671708907 QLSLEGS(ph)GLGVEDLKDNTPSGK ddPTM_A459_Selumetinib_30min_R2 2 QLSLEGSGLGVEDLKDNTPSGK 22 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 QLS(0.432)LEGS(0.568)GLGVEDLKDNTPSGK;QLS(0.066)LEGS(0.934)GLGVEDLKDNTPSGK 118.19 1.8234e-05 35792000.0 105788.0 85678.0 111132.0 107627.0 108417.0 63019.0 89544.0 87322.0 59709.0 88161.0 True False 99908.72646291724 92249.22710180905 103981.88811137274 92968.01693306943 94796.68719972257 71699.29522047577 93707.97342806989 87576.09256306461 71652.46840885252 85615.56286021319 1.1669458580333214 1.0774819906566149 1.2145208725795185 1.085877541736901 1.1072366288650073 0.83745633183001 1.0945203219777857 1.0228992210919927 0.8369093890773271 1.0 16.38558544744302 -6.596815426322463 9.964778674180737 0.9683400140452344 1.1325031400623085 0.5236608300525512 0.08211193488409779 0.32044618636858296 40.74927347703899 0.026579954460349997 0.02657337390084224 2.5303731679470473e-07 6.596815426322463 0.16416312601707406 QLSLPLT(ph)QSK ddPTM_A459_Selumetinib_30min_R2 2 QLSLPLTQSK 10 0 Q9C0I1-3;Q9C0I1-2;Q9C0I1 Q9C0I1-3 MTMR12 Myotubularin-related protein 12 1 QLSLPLT(0.995)QS(0.005)K;QLS(0.333)LPLT(0.666)QSK 155.86 0.0012124 78264000.0 341120.0 251993.0 331820.0 344010.0 389120.0 250176.0 247198.0 293375.0 226001.0 262292.0 True False 322161.9160115543 271320.05281479604 310471.06245830026 297155.24454965006 340235.2668230628 284635.473128386 258693.19681354455 294228.67267915397 271207.5149955465 254718.94844354142 1.2647740499092146 1.0651742026759123 1.218876979335192 1.166600468341344 1.3357281384132131 1.1174491527530612 1.0156024842057796 1.155111052699599 1.0647323909460147 1.0 17.9585467595641 -6.98940258917378 24.995577987634448 1.0710357326411246 1.2028645368722135 0.4693896972785925 0.07565906781981237 212.12801034878763 500333.3536893898 0.026185246050843464 0.023071330033617617 1.0247015917387093e-07 6.98940258917378 0.1318288042310889 QLSPEDSS(ph)SPVK ddPTM_A459_Selumetinib_30min_R1 2 QLSPEDSSSPVK 12 0 Q96AY2;Q96AY2-2 Q96AY2 EME1 Crossover junction endonuclease EME1 1 QLSPEDS(0.001)S(0.499)S(0.499)PVK;QLSPEDS(0.178)S(0.609)S(0.213)PVK 209.53 6.9803e-06 30693000.0 13028.7 12191.9 10481.900000000001 10059.1 10767.3 9718.400000000001 12889.7 12984.3 7065.299999999999 12742.0 True False 13332.243360562908 10764.466680139463 9058.515552955312 8302.467017692896 9793.39961612121 9620.641719601192 11917.419551442996 12639.914185049556 11989.298070904873 14377.559817590438 0.927295280263858 0.7486991406545579 0.630045408809396 0.5774600921872097 0.6811586764632571 0.6691428755407212 0.8288902778107348 0.8791418255540878 0.8338896323864631 1.0 13.81153121959707 -7.443880487371514 3.0376129386778707 0.8909968308260949 0.6972204663093354 0.46825971962147606 0.0955531199819557 0.26256402165530507 4.706675556874397 0.049678499744928044 0.029926334959233743 3.59848347477502e-08 7.443880487371514 -0.1937763645167595 QLSPEDSSS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 4 QLSPEDSSSPVK 12 0 Q96AY2;Q96AY2-2 Q96AY2 EME1 Crossover junction endonuclease EME1 1 QLSPEDS(0.029)S(0.09)S(0.881)PVK;QLSPEDSS(0.078)S(0.922)PVK;QLSPEDSS(0.006)S(0.994)PVK;QLSPEDS(0.017)S(0.399)S(0.584)PVK 185.66 0.00010536 54470000.0 360634.0 281212.0 336011.0 373783.0 349788.0 302290.0 357774.0 346649.0 284530.0 316344.0 True False 340591.4060122854 302780.0561609039 314392.4180811149 322873.11058836017 305844.50429560395 343927.70358459535 374411.19991573173 347657.69119916833 341443.95043244376 307210.32675957883 1.1086587147144646 0.9855790310000156 1.0233784176374927 1.0509839105800598 0.9955541127852653 1.1195186933079608 1.2187454890106737 1.1316601719291923 1.1114338311278709 1.0 18.22886718696212 -6.8363610578566005 6.885976733310729 1.1318970618713107 1.0308631658582081 0.3154215120656817 0.05936949300084532 0.21958437934511754 16.49001725605661 0.02021904254744894 0.017881093637870826 1.457601955064376e-07 6.8363610578566005 -0.10103389601310253 QLSS(ph)GVSEIR ddPTM_A459_Selumetinib_30min_R1 1 QLSSGVSEIR 10 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 QLS(0.338)S(0.659)GVS(0.003)EIR 89.189 0.031193 47191000.0 1436.5 1590.2 1542.0 1371.1 2017.9 1346.0 1921.1 1807.0 659.48 1480.7 True False 1469.9676550575753 1404.018644736077 1332.6048695997008 1131.6631237346023 1835.3813012891803 1332.4604620702173 1776.1898803135173 1759.0724900367793 1119.0893934865248 1670.7622682393792 0.879818561264615 0.8403461530260723 0.7976029234871201 0.6773334215448436 1.098529297781709 0.7975164913643528 1.06310150407289 1.052856246203393 0.66980767686704 1.0 10.706290752452711 -6.255134866294162 24.999284645982797 0.9479453944985147 0.8016608837290253 0.23367594034329897 0.13142329960530558 791.4642844612783 3138391.1938802316 0.03824908464330801 0.04816751992663897 5.557316529423384e-07 6.255134866294162 -0.14628451076948934 QLSS(ph)GVSEIR ddPTM_A459_Selumetinib_30min_R2 4 QLSSGVSEIR 10 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 QLS(0.092)S(0.906)GVS(0.002)EIR;QLS(0.07)S(0.732)GVS(0.198)EIR;QLS(0.092)S(0.908)GVS(0.001)EIR;QLS(0.291)S(0.667)GVS(0.042)EIR 153.49 0.00059339 2241412000.0 177784.0 146009.0 191812.0 183540.0 231969.0 106052.0 133230.0 174391.0 99319.0 124364.0 True False 167903.4770057403 157207.42080706853 179471.02474911505 158541.5353758399 202826.9803908284 120659.7003557959 139425.45899023677 174898.4489380159 119185.57520472312 120773.28818352269 1.3902368605763247 1.3016737655447608 1.4860158852046608 1.312720202955193 1.6794026513761877 0.9990594954444382 1.1544395378088153 1.4481550644894805 0.9868537736888728 1.0 16.881941878880205 -6.77581729471124 24.99957764702973 1.1480074101851707 1.4228088260156542 0.48709743955717333 0.1605870763049145 237.25394568245176 412522.39291645266 0.055565449950549316 0.049225728851118235 1.6756476634788641e-07 6.77581729471124 0.27480141583048345 QLSS(ph)SSSYSGDISR ddPTM_A459_Selumetinib_30min_R2 1 QLSSSSSYSGDISR 14 0 A0A0A0MS99;I3L4X2;P33527-8;P33527-6;P33527-7;P33527-5;P33527-4;P33527-2;P33527-3;P33527;P33527-9 A0A0A0MS99 ABCC1 Multidrug resistance-associated protein 1 1 QLS(0.067)S(0.382)S(0.382)S(0.067)S(0.067)Y(0.012)S(0.022)GDISR 80.37100000000002 0.034113 22713000.0 39948.0 16576.0 32373.0 32869.0 22509.0 19685.0 63114.0 34679.0 27924.0 24256.0 True False 37727.850084514444 17847.325899759388 30290.156425057336 28392.18549781238 19681.21818698686 22396.430067361674 66048.92605801845 34779.910148582516 33509.58026174944 23555.66625534341 1.6016464860532735 0.7576659350788206 1.2858968240045539 1.2053229651855781 0.8355194870585473 0.9507873742387238 2.803950664865435 1.4764986806812554 1.422569835151577 1.0 14.523786517740225 QLSSSS(ph)GNTDTQADEDER ddPTM_A459_Selumetinib_30min_R2 1 QLSSSSGNTDTQADEDER 18 0 J3KP58;P30622-2;P30622-1;P30622;F5H0N7;A0A3B3IS27;A0A3B3ITA2 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 QLSSS(0.02)S(0.98)GNTDTQADEDER 324.39 2.5320999999999972e-250 0.0 10886.0 7784.6 8953.2 7110.7 11421.0 6337.8 8736.8 11016.0 9715.5 7127.6 True False 10280.999700110753 8381.653788565807 8377.160859507105 6142.210393358313 9986.19187496454 7210.774421179818 9143.078511640768 11048.054736203021 11658.871473751138 6921.807668271174 1.4853056011997785 1.210905328529484 1.2102562308841827 0.8873708556673061 1.442714440151259 1.0417472959026637 1.3209090673743595 1.5961227566096818 1.6843680195267714 1.0 12.756933139501713 -7.540532213093414 8.077279979321288 1.4768660409471053 1.2061393839088348 0.13415220386441196 0.23393978296493323 0.2718662377023732 92.32040841833367 0.10465663963340578 0.06140745858677126 2.8804993854504873e-08 7.540532213093414 -0.2707266570382705 QLSSSS(ph)SYSGDISR ddPTM_A459_Selumetinib_30min_R1 1 QLSSSSSYSGDISR 14 0 A0A0A0MS99;I3L4X2;P33527-8;P33527-6;P33527-7;P33527-5;P33527-4;P33527-2;P33527-3;P33527;P33527-9 A0A0A0MS99 ABCC1 Multidrug resistance-associated protein 1 1 QLSSS(0.011)S(0.43)S(0.43)YS(0.128)GDISR 241.39 1.2595999999999993e-19 15631000.0 1407.2 887.8 1864.8 852.14 1990.4 1141.5 1484.2 1869.1 519.27 1294.6 True False 1439.9850220654505 783.855963272977 1611.5704026131777 703.3297456488981 1810.368671433661 1130.0175463990738 1372.2455990637238 1819.52539630755 881.1632640197546 1460.7745204718715 0.9857681674241515 0.536602981697524 1.1032300878937804 0.48147728194335065 1.2393210903273837 0.7735742447328875 0.9393959025383669 1.2455894943456378 0.6032164797994382 1.0 10.512517791139125 -6.267165234938078 24.987719213445217 0.9680925448905414 0.782933477027731 0.122729728353691 0.24873066182154716 1020.410921068228 4453083.120731185 0.07121111540403822 0.08290104213708814 5.405486226309949e-07 6.267165234938078 -0.18515906786281044 QLSSSSSYS(ph)GDISR ddPTM_A459_Selumetinib_30min_R1 1 QLSSSSSYSGDISR 14 0 A0A0A0MS99;I3L4X2;P33527-8;P33527-6;P33527-7;P33527-5;P33527-4;P33527-2;P33527-3;P33527;P33527-9 A0A0A0MS99 ABCC1 Multidrug resistance-associated protein 1 1 QLSS(0.001)S(0.006)S(0.072)S(0.055)YS(0.865)GDISR 142.4 0.00039585 0.0 1242.2 842.48 1300.2 828.18 1675.4 1126.0 1352.8 1518.2 521.45 1255.8 True False 1271.140843099561 743.8420499416742 1123.6399814873744 683.5539098639946 1523.860365815894 1114.6734623261998 1250.757206854471 1477.932404191389 884.8625647988544 1416.9941625278664 0.8970685107353523 0.5249436233489395 0.7929743193033635 0.48239712480152996 1.0754175324881947 0.7866464744905248 0.8826833870812603 1.0430052877245528 0.6244645095928212 1.0 10.468618099580372 -6.263257996483003 24.999792075306377 0.8974493311782866 0.6721477674582039 0.31262211691169506 0.16530417023438868 197.38170448975998 2713323.5691727395 0.047004587315876596 0.05607072095537612 5.454337450822876e-07 6.263257996483003 -0.2253015637200827 QLSST(ph)SPLAPYPTSQMVSSDR ddPTM_A459_Selumetinib_30min_R1 1 QLSSTSPLAPYPTSQMVSSDR 21 0 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 QLS(0.006)S(0.05)T(0.472)S(0.472)PLAPYPTSQMVSSDR 227.06 2.2787e-24 5709500.0 549.16 445.44 548.61 636.15 627.79 465.21 587.89 547.11 289.38 546.94 True False 561.9543595206526 393.2876777205621 474.11177529902204 525.0583445144537 571.0065053453269 460.53040977688426 543.5449839870454 532.5988655362604 491.056724521033 617.1450766467519 0.9105709188737643 0.6372694081227781 0.7682339100477005 0.8507859243848301 0.9252386950048792 0.7462271469119854 0.8807410195028833 0.8630043172832682 0.7956909049476373 1.0 9.269465863518812 -14.522878739061966 0.13097871090390825 1.6005942900844228 0.7444587025865013 0.3040622287695316 0.08220795658222196 176.24552005434293 1.446946561581333 27.844905698404762 0.613464418846724 3.0000000429549907e-15 14.522878739061966 -0.8561355874979215 QLSST(ph)SPLAPYPTSQMVSSDR ddPTM_A459_Selumetinib_30min_R2 3 QLSSTSPLAPYPTSQMVSSDR 21 0 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 QLSST(0.5)S(0.5)PLAPYPTSQMVSSDR;QLSST(0.5)S(0.5)PLAPYPTSQMVSSDR;QLSS(0.001)T(0.499)S(0.499)PLAPYPTSQMVSSDR 288.3 3.199599999999998e-153 7850600.0 30818.300000000003 32698.1 30980.8 35202.0 34848.0 25999.0 31159.6 36640.0 37563.0 44344.0 True False 29105.542261429666 35205.939129037295 28987.529057344593 30407.426873162887 30470.082694927267 29580.126254576364 32608.583141576055 36746.61633392149 45076.64959791194 43063.67350045136 0.6758722583461116 0.8175321858844274 0.6731318232068791 0.7061038783150764 0.7075588359782614 0.6868927764433828 0.7572178704455921 0.8533089108976348 1.046744179811773 1.0 15.394183771856108 -7.995656640364817 2.1479671374985148 1.0261663027715815 0.7150632215414583 0.8928942680308535 0.042286091287981796 0.09449329147259634 0.8047363668857564 0.034007772608480785 0.01154664592691217 1.0100511318335261e-08 7.995656640364817 -0.3111030812301232 QLSSTS(ph)PLAPYPTSQMVSSDR ddPTM_A459_Selumetinib_30min_R2 1 QLSSTSPLAPYPTSQMVSSDR 21 0 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 QLSS(0.001)T(0.004)S(0.995)PLAPYPTSQMVSSDR 158.92 1.3142999999999998e-07 6155600.0 4386.9 5580.0 5273.9 5887.6 5896.5 6318.3 5888.1 7196.6 5995.8 7843.4 True False 4143.093660152109 6007.968057472091 4934.583015788154 5085.698723323502 5155.728954621171 7188.5884731831975 6161.908317048808 7217.540914538736 7195.127536649377 7616.9406623994255 0.5439314606459053 0.7887639307904901 0.6478431741167985 0.667682597086354 0.6768766074379601 0.9437632235563075 0.8089741787627023 0.947564282621722 0.9446217130412603 1.0 12.894995941508805 -6.756971772309631 24.794148319874182 0.9182068081148336 0.6710878969480035 0.7712567219077211 0.07171922368527395 49.575274161901035 275130.7449088564 0.02317661465387692 0.022420838810021996 1.7499604265095227e-07 6.756971772309631 -0.24711891116683005 QLST(ph)EQAVLQESLEK ddPTM_A459_Selumetinib_30min_R2 2 QLSTEQAVLQESLEK 15 0 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 QLS(0.147)T(0.842)EQAVLQES(0.01)LEK;QLS(0.093)T(0.907)EQAVLQESLEK 241.51 7.8121e-20 8934100.0 90515.0 98756.0 98738.0 92828.0 99226.0 47628.8 83925.0 90322.0 63320.0 57706.6 True False 85484.5386602539 106330.26764941089 92385.30457780596 80184.66626276835 86760.34278830505 54189.23486880137 87827.67879423269 90584.822066388 75985.7693086224 56040.460518247 1.5254074978991257 1.8973839020253827 1.6485464916499917 1.4308352486978566 1.5481732659933358 0.9669662662953518 1.5672190767532264 1.616418231197319 1.3559090807949576 1.0 15.774181190861745 -5.807524454253927 2.2200011183946735 1.368867324639348 1.7264296545884377 0.3242508639475862 0.22377775157905178 0.37780886284953774 3.8005412939592604 0.06766501440499335 0.12319052607109632 1.5576703230607771e-06 5.807524454253927 0.35756232994908976 QLT(ph)QPETHFGR ddPTM_A459_Selumetinib_30min_R2 2 QLTQPETHFGR 11 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 1 QLT(1)QPETHFGR;QLT(0.996)QPET(0.004)HFGR 104.81 0.016347999999999998 18638200.0 101880.0 116755.0 142399.0 120411.0 101726.0 68434.0 68759.0 59430.0 92267.0 102679.0 True False 96217.91745795372 125709.73307350432 133237.20337230837 104010.81407943928 88946.27043802138 77860.16231799981 71956.4297433738 59602.9314608339 110722.97815537998 99714.39047791892 0.9649351211674962 1.260698004279953 1.336188314783039 1.0430872974394982 0.8920103709375623 0.7808317530180503 0.7216253280844961 0.5977365069892552 1.1104011930945799 1.0 16.605514104563795 -6.182247882848887 2.589055311472267 0.8137030459799964 1.1935785767323208 0.4604283965237609 0.16205406429701102 0.22914070975541567 3.0096323757115204 0.051625267801122275 0.06891934508237473 6.572825722074945e-07 6.182247882848887 0.3798755307523244 QLTQPETHFGR ddPTM_A459_Selumetinib_30min_R2 1 QLTQPETHFGR 11 0 H0Y5J4;Q9UJU6-5;Q9UJU6;B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 H0Y5J4;B4DDD6 DBNL Drebrin-like protein 0 103.44 0.019957 0.0 7452.5 7522.2 8367.6 8877.6 10091.0 9316.5 10632.0 9169.4 7734.7 9102.4 False True 7038.319884721235 8099.128552314796 7829.237725954035 7668.455565285809 8823.2783653154 10599.763308233418 11126.40906690832 9196.08143592411 9281.856125574894 8839.59006112458 0.7962269557810031 0.916233501362666 0.8857014490282814 0.8675125783276676 0.998154699969525 1.1991238547192207 1.258701929611067 1.0403289487786698 1.050032417950618 1.0 13.109763750376532 -6.485707734714516 3.5792176825097313 1.1210392235838151 0.8729906276605814 0.6830948887612391 0.07756634686571418 0.1426491226260258 3.7862670705869297 0.027091354809185206 0.029533120414156684 3.2680768854761546e-07 6.485707734714516 -0.2480485959232337 QLVAGNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 QLVAGNSPK 9 0 Q96EU6-2;Q96EU6 Q96EU6-2 RRP36 Ribosomal RNA processing protein 36 homolog 1 QLVAGNS(1)PK;QLVAGNS(1)PK;QLVAGNS(1)PK 135.1 0.002756 117153000.0 22704.2 26070.9 28200.2 27357.0 20240.7 22564.0 21412.0 22633.2 17496.7 23033.8 True False 23233.163685317228 23018.50690796742 24370.76773261054 22579.613504490935 18409.93225878582 22337.026646472805 19796.875601099906 22032.894013005214 29690.621991592918 25990.41259821179 0.8939128456512356 0.8856537702503098 0.9376829875446961 0.8687670278094959 0.7083355136906319 0.8594333222709073 0.7616991660402491 0.8477315983248813 1.142368243651342 1.0 14.665691916347988 -8.249153391470776 24.28611045318331 1.0711841099976447 0.8437073347535234 0.6237398528741446 0.07013433069735103 295.61563824111397 584357.027224801 0.050362839335604245 0.018702577441363527 5.634386158975158e-09 8.249153391470776 -0.22747677524412124 QLVAGNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 QLVAGNSPK 9 0 Q96EU6-2;Q96EU6 Q96EU6-2 RRP36 Ribosomal RNA processing protein 36 homolog 1 QLVAGNS(1)PK;QLVAGNS(1)PK;QLVAGNS(1)PK 101.56 0.016919 199780000.0 661520.0 589100.0 556820.0 565820.0 492980.0 396110.0 557970.0 506240.0 371196.0 490067.0 True False 624755.3666743769 634282.0757449479 520994.8074197777 488754.33990605775 431047.44510288275 450670.55697143194 583916.7105965795 507713.07458745677 445445.57208280906 475917.49236301787 1.3127388185972144 1.3327563830352624 1.0947166594632667 1.0269728424549023 0.905718852573905 0.9469510245016836 1.2269284486630774 1.0668090220146522 0.9359722624841753 1.0 18.860351956213208 -5.359353815104626 3.038703276563956 1.0209713381608796 1.329260961233954 0.6697922886439032 0.08480868736123964 0.16291932453001035 2.8539752853344114 0.02511906941305416 0.06368956868295549 4.371658056996199e-06 5.359353815104626 0.3082896230730745 QLVAGNS(ph)PKK ddPTM_A459_Selumetinib_30min_R2 1 QLVAGNSPKK 10 1 Q96EU6-2;Q96EU6 Q96EU6-2 RRP36 Ribosomal RNA processing protein 36 homolog 1 QLVAGNS(1)PKK 74.237 0.032308 65906000.0 180320.0 175100.0 160610.0 166070.0 143220.0 109020.0 138400.0 143890.0 96736.0 140930.0 True False 170298.53627815293 188529.60696476014 150276.52745894578 143450.9795132711 125227.42319695484 124036.5154149744 144835.87423439726 144308.69607772832 116085.90302967317 136860.98471988586 1.2443176309647623 1.3775263078124473 1.098023134690413 1.0481510110925552 0.9149972393758419 0.9062956522550282 1.0582699995242153 1.0544180751956866 0.8482030380481832 1.0 17.062351707202588 -5.52226048687794 2.226582293211294 0.9726064791938365 1.313561069338813 0.7623854457856042 0.07381027301859736 0.14377955133152032 1.4037587916765988 0.02131269828326561 0.05211641561856646 3.0042738191097435e-06 5.52226048687794 0.3409545901449764 QLVHELDEAEYR ddPTM_A459_Selumetinib_30min_R1 4 QLVHELDEAEYR 12 0 Q06323-3;Q06323;Q06323-2;H0YKK6 Q06323-3 PSME1 Proteasome activator complex subunit 1 0 ;;; 176.87 0.00014555 15496900.0 5865.99 7190.289999999999 6184.67 5986.6 7056.999999999999 5261.18 5783.75 5739.27 3566.63 5344.0599999999995 False True 6002.656153770401 6348.447504124864 5344.825783960557 4941.152692399947 6418.695596014547 5208.257305969231 5347.47708097616 5587.045915823677 6052.3106136514325 6030.022156552535 0.9954617077563477 1.0528066629450625 0.8863691782877765 0.8194252963118277 1.0644563866220058 0.863721089367751 0.8868088610860765 0.9265382067879308 1.0036962479606608 1.0 12.557947587797354 -5.2577380159601 24.974298187733275 0.9254998439666886 1.0241341891188798 0.2101048494801635 0.07121502719183187 441.08490307103796 2976108.971254283 0.018064436822357803 0.04413569599842189 5.524105752465017e-06 5.2577380159601 0.09863434515219116 QLVHELDEAEYR ddPTM_A459_Selumetinib_30min_R2 4 QLVHELDEAEYR 12 0 Q06323-3;Q06323;Q06323-2;H0YKK6 Q06323-3 PSME1 Proteasome activator complex subunit 1 0 ;;; 183.06 0.0001465 11650300.0 76120.0 61111.0 69130.0 77081.0 81917.0 64913.0 62829.0 61519.0 54594.0 69154.0 False True 71889.55513250323 65798.01719716434 64682.25106305295 66582.43482785845 71625.85411272834 73854.17652845559 65750.67299330173 61698.01010498131 65514.32548381135 67157.3443363299 1.070464531361961 0.9797590695016478 0.9631448608080531 0.9914393650589837 1.0665379165980677 1.09971853798428 0.9790540951711337 0.9187083068084443 0.9755347852307833 1.0 16.035257561156158 -7.509277127745188 24.783390469346884 0.9580491599986856 1.0247019472830556 0.3013167592413024 0.04472226586574063 758.1886206403633 1381497.0478519248 0.021103309012856508 0.013529421122525455 3.0954434347985255e-08 7.509277127745188 0.06665278728437007 QLVNNKDT(ph)TSFEDISPQGVSDDSSTGSR ddPTM_A459_Selumetinib_30min_R1 1 QLVNNKDTTSFEDISPQGVSDDSSTGSR 28 1 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;A0A2R8Y802 Q3V6T2 CCDC88A Girdin 1 QLVNNKDT(0.443)T(0.443)S(0.114)FEDISPQGVSDDSSTGSR 138.23 2.3082e-12 16390000.0 1208.6 885.87 1752.8 1512.3 1600.0 1107.2 1151.7 1099.3 799.2 1150.1 True False 1236.75802847378 782.15192857021 1514.7793874412157 1248.2051943868714 1455.280282502944 1096.0625732571655 1064.8263417610108 1070.1429929703554 1356.1840287414793 1297.7265379226778 0.9530189853815485 0.6027093580302607 1.1672562309359744 0.9618399238293476 1.121407507649854 0.8446021108666516 0.8205321465225797 0.8246290429441133 1.0450460779760093 1.0 10.341770689611185 -1.5228787459602517 0.010096519036517052 1.7468853024290865 7.026103468949542e-07 0.02021335299024607 0.15648780434827156 84778.6979541899 66.41861927964074 4945.540450788039 6664.616208274769 0.029999999953033193 1.5228787459602517 -1.7468845998187397 QLVNNKDTTS(ph)FEDISPQGVSDDSSTGSR ddPTM_A459_Selumetinib_30min_R1 1 QLVNNKDTTSFEDISPQGVSDDSSTGSR 28 1 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;A0A2R8Y802 Q3V6T2 CCDC88A Girdin 1 QLVNNKDT(0.026)T(0.193)S(0.779)FEDIS(0.002)PQGVSDDSSTGSR 94.49 8.406399999999998e-07 15384000.0 221.36 395.67 370.54 592.01 659.41 326.2 427.09 284.73 252.72 471.43 True False 226.51725730841957 349.3447724580074 320.2227032305271 488.62656690403463 599.7664819282909 322.91872416590263 394.87425744786844 277.1780354666145 428.84738206149524 531.9426326170665 0.42583023698249856 0.656733923993441 0.6019872888455778 0.9185700429763934 1.1275021875527116 0.6070555438980288 0.742324892263579 0.5210675333596523 0.8061910359612271 1.0 9.055126856362973 -4.9789233317521715 1.4826512137456969 0.7897334581997146 0.3850619490431786 0.30252472701056954 0.17603953125886723 1.1390089815295072 3.0686779042780947 0.05429938887944497 0.6127280549799959 1.049727726152954e-05 4.9789233317521715 -0.40467150915653605 QLVNNKDTTS(ph)FEDISPQGVSDDSSTGSR ddPTM_A459_Selumetinib_30min_R2 1 QLVNNKDTTSFEDISPQGVSDDSSTGSR 28 1 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;A0A2R8Y802 Q3V6T2 CCDC88A Girdin 1 QLVNNKDT(0.06)T(0.206)S(0.731)FEDIS(0.002)PQGVSDDSSTGSR 73.654 8.6235e-05 12949000.0 18596.0 17890.0 16594.0 21745.0 23756.0 15245.0 13168.0 18152.0 8086.3 20030.0 True False 17562.508765686158 19262.10547458344 15526.360106181126 18783.293487782717 20771.558898665407 17344.86036966872 13780.338091896994 18204.81931477462 9703.785950099718 19451.681855810053 0.9028786762950467 0.9902539850984665 0.7982014214130041 0.965638530745983 1.0678541348064008 0.891689494936293 0.7084394138279063 0.9358994995765364 0.49886616602261974 1.0 14.247607280269204 -7.048385242144906 7.309577088768129 0.7824956277455644 0.9443331910666515 0.22228398143278272 0.14060107852426101 0.3878784815080071 50.72308391729519 0.05076679679139893 0.039700662116645906 8.945708818697722e-08 7.048385242144906 0.16183756332108712 QLVT(ph)SPSPMSSSDGK ddPTM_A459_Selumetinib_30min_R2 2 QLVTSPSPMSSSDGK 15 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 QLVT(0.69)S(0.087)PS(0.191)PMS(0.014)S(0.014)S(0.004)DGK;QLVT(0.584)S(0.277)PS(0.135)PMS(0.003)S(0.001)SDGK 153.41 0.0004866000000000001 18586700.0 167387.0 142966.0 166991.0 192318.0 191058.0 147748.0 151062.0 175002.0 140620.0 167506.0 True False 158084.30064325174 153931.03249185535 156246.9808660538 166123.95663294557 167055.58595980852 168098.94587719347 158086.6823236744 175511.22684685918 168747.92925108143 162669.6665471455 0.9718117950247055 0.9462798797048159 0.9605170046916508 1.0212349982582583 1.0269621221077003 1.0333761016745826 0.9718264362327022 1.0789425623860358 1.037365679987881 1.0 17.311585727279123 -5.768119717573244 5.113969065811522 1.0262272102169114 0.9574848949694028 0.5589004070694492 0.026332317840684693 0.12536521741425136 9.229958849248424 0.007428733048480039 0.01205497127969226 1.7056121553184594e-06 5.768119717573244 -0.06874231524750862 QLVTSPS(ph)PMSSSDGK ddPTM_A459_Selumetinib_30min_R2 2 QLVTSPSPMSSSDGK 15 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 QLVT(0.084)S(0.084)PS(0.624)PMS(0.158)S(0.04)S(0.01)DGK;QLVT(0.045)S(0.284)PS(0.654)PMS(0.013)S(0.003)S(0.001)DGK 162.76 1.0658e-05 2250400.0 40612.0 39233.0 38736.0 46267.0 46425.0 32575.0 39449.0 39390.0 26908.0 33469.0 True False 38354.947622717074 42242.04494602195 36243.76793256794 39965.354784973235 40592.676455234105 37061.9105635919 41283.45666671055 39504.61837863448 32290.351872337567 32502.663007094652 1.180055542351868 1.2996487376065584 1.1151014895196951 1.2296024721497323 1.2489030959208964 1.1402730464116757 1.2701561302130606 1.2154271288482252 0.9934678849326671 1.0 14.988270305374773 -8.261244636044564 24.946838903080636 0.9967339123880574 1.213372934242545 0.7242506819283971 0.05322603648751061 7.951667140436104 1019022.4054919836 0.039481278339003924 0.01277258106608025 5.479682100464997e-09 8.261244636044564 0.21663902185448758 QLVYEADGCS(ph)PHGTLK ddPTM_A459_Selumetinib_30min_R2 1 QLVYEADGCSPHGTLK 16 0 A0A1W2PR28;Q5JU85-3;Q5JU85 A0A1W2PR28 IQSEC2 IQ motif and SEC7 domain-containing protein 2 1 QLVYEADGCS(1)PHGTLK 77.469 0.041568 0.0 20882.0 11304.0 15953.0 20795.0 20508.0 12388.0 15386.0 15700.0 12464.0 16616.0 True False 19721.46203726923 12170.980451911202 14926.601348313088 17962.68512662413 17931.601696153833 14094.334552932496 16101.479486780614 15745.68440072508 14957.148273257588 16136.252906447304 1.2221834989577687 0.7542631193545708 0.9250351636685804 1.1131881255683014 1.111261815250131 0.8734577125585984 0.9978450127257986 0.9757955884810053 0.9269282255288277 1.0 13.97801798041378 -9.803149972012484 11.847130025195165 0.9999957997485597 0.9838447448202274 0.0 0.1271306630154276 0.0 0.0 0.12059907944767843 0.029249573112649075 1.5734394253138539e-10 9.803149972012484 -0.016151054928332242 QLVYVEQAGS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 QLVYVEQAGSSPK 13 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 QLVYVEQAGS(0.993)S(0.007)PK 215.09 1.0919e-06 8064400.0 4863.8 5216.2 6671.1 5850.4 4724.5 5311.8 5518.9 5132.1 3829.1 5766.3 True False 4977.117076692678 4605.484879054411 5765.201261729289 4828.737465609303 4297.169809178223 5258.368114728515 5102.604929708118 4995.9800365897945 6497.703033601102 6506.460773518427 0.764949985858634 0.7078325743234987 0.8860733142653998 0.7421450207250109 0.6604465866708806 0.8081764107654806 0.7842366391381221 0.7678490980724338 0.9986539932811138 1.0 12.66765727921008 -8.260929313659407 7.45518337447911 1.0006128334967845 0.7649539807657673 0.7350306586640649 0.05622776015532202 0.05917345100438213 29.180426418494118 0.04549564878613463 0.014497287911776879 5.483662104628342e-09 8.260929313659407 -0.23565885273101728 QLVYVEQAGSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 QLVYVEQAGSSPK 13 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 QLVYVEQAGS(0.068)S(0.932)PK;QLVYVEQAGS(0.226)S(0.774)PK;QLVYVEQAGS(0.203)S(0.797)PK;QLVYVEQAGS(0.265)S(0.735)PK 231.13 3.6768e-13 41850000.0 12351.3 11110.2 14261.8 12847.7 10601.0 11390.300000000001 11100.8 11920.2 9342.11 12538.099999999999 True False 12639.061258553855 9809.412619008153 12325.1258944598 10604.09037619798 9642.141421758563 11275.723923564938 10263.457718694648 11604.037573733487 15852.878349281866 14147.487266436248 0.8933785216077903 0.6933678351688769 0.8711883362991355 0.7495387821521716 0.6815444495669384 0.7970124808181073 0.7254615272242625 0.8202189798935613 1.1205437439686916 1.0 13.788258218461026 -8.168361576054064 4.872601254047261 1.058222248322753 0.7708036170364777 0.7170717001924828 0.07097551287776648 0.1028701421868701 3.906582514219169 0.048819067071601385 0.017236671247586363 6.786383904222782e-09 8.168361576054064 -0.2874186312862753 QLVYVEQAGSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 QLVYVEQAGSSPK 13 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 QLVYVEQAGS(0.439)S(0.561)PK;QLVYVEQAGS(0.24)S(0.76)PK;QLVYVEQAGS(0.401)S(0.599)PK;QLVYVEQAGS(0.45)S(0.55)PK 235.71 3.335400000000001e-14 34660300.0 239419.0 209832.0 211669.0 220556.0 201031.0 179795.0 254203.0 217739.0 147992.0 179178.0 True False 226113.05045019469 225925.4396837788 198050.4469877817 190515.89231967798 175775.68854005763 204560.12923349193 266023.94319368835 218372.58444136797 177594.53524197213 174004.66557964732 1.2994654464980178 1.298387252612866 1.138190440630041 1.0948895633633051 1.0101780199657902 1.1756014044339427 1.5288322431327048 1.2549812024517935 1.0206308816511682 1.0 17.40876646394978 -8.269976125732683 21.35337743600872 1.010314940475494 1.221588523494555 0.29336029134664166 0.13323158056040776 137.59744576054027 344146.79991961055 0.13333259725881194 0.037226148044693506 5.3706131917934465e-09 8.269976125732683 0.21127358301906085 QMDTVLSS(ph)SPDVLFDPINGLTPDEEALSNER ddPTM_A459_Selumetinib_30min_R1 1 QMDTVLSSSPDVLFDPINGLTPDEEALSNER 31 0 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 QMDT(0.004)VLS(0.086)S(0.454)S(0.454)PDVLFDPINGLT(0.001)PDEEALSNER 82.508 4.8924e-06 3448300.0 68.12 0.0 0.0 0.0 0.0 0.0 166.43 0.0 0.0 0.0 True False 69.70706346155376 0.0 0.0 0.0 0.0 0.0 153.87605110643827 0.0 0.0 0.0 0.0 QMDTVLSSS(ph)PDVLFDPINGLTPDEEALSNER ddPTM_A459_Selumetinib_30min_R1 1 QMDTVLSSSPDVLFDPINGLTPDEEALSNER 31 0 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 QMDT(0.001)VLS(0.072)S(0.329)S(0.598)PDVLFDPINGLTPDEEALSNER 126.33 3.1394999999999997e-18 4135100.0 507.07 575.07 504.95 394.82 559.0 438.99 618.72 509.57 284.29 293.97 True False 518.8837444135362 507.74053705721036 436.3805634918083 325.8720986892971 508.43854869946597 434.57415917102884 572.0494522656702 496.0545482833659 482.4193662799241 331.70391301028593 1.5642979297547386 1.5307040922410393 1.3155725524355704 0.982418614637181 1.532808413639967 1.3101267188173116 1.7245785467955312 1.4954739116025548 1.4543674263648634 1.0 8.373752221036133 QMEQISQFLQAAER ddPTM_A459_Selumetinib_30min_R1 1 QMEQISQFLQAAER 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 228.7 4.8637000000000006e-11 52713000.0 623.12 965.16 1191.2 1123.1 1068.2 805.87 833.94 596.44 615.76 808.19 False True 637.6374836195444 852.1586185092895 1029.441582793231 926.9716681980391 971.5814986060278 797.7636794714164 771.0352343910538 580.620473689838 1044.8997466689855 911.9290589372481 0.6992182970489392 0.9344571380392084 1.1288614752477903 1.0164953722149412 1.0654134650981493 0.8748089247217554 0.8454991392527941 0.6366947823402915 1.1458125348990413 1.0 9.83277778795838 -6.813569349277 20.262901723247 0.8744129021707765 0.9785080924305447 0.029271105886098714 0.1607236603549415 43.47957195127388 16898.361343337347 0.05699195716094057 0.05026245694559196 1.536139478982375e-07 6.813569349277 0.10409519025976821 QMGYTEAIEVIQAAS(ph)SPVK ddPTM_A459_Selumetinib_30min_R1 1 QMGYTEAIEVIQAASSPVK 19 0 P19838-3;P19838;P19838-2 P19838-3 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 1 QMGYTEAIEVIQAAS(0.5)S(0.5)PVK 62.203 0.021695 5177200.0 1002.6 1052.5 1145.3 1181.6 1027.1 979.37 943.57 1029.0 668.69 828.43 True False 1025.9586292800032 929.2728107060249 989.7745506825789 975.2557413790433 934.1989863492336 969.5184269968125 872.3957552274344 1001.7075773369379 1134.7180908147393 934.7670600915433 1.0975553943669445 0.9941223331243825 1.058846201304578 1.0433141934671242 0.9993922830975087 1.0371764992466315 0.9332760989053244 1.0716119770403967 1.2139046605938537 1.0 9.868463086197691 -7.999322708652844 24.99781953903775 1.1188876698247974 1.0224567322342162 0.22096536251468601 0.0632978725253635 25.61128488603175 945277.2757713987 0.03272516750430274 0.015488101560846805 1.0015607376447863e-08 7.999322708652844 -0.09643093759058119 QMGYTEAIEVIQAASS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 QMGYTEAIEVIQAASSPVK 19 0 P19838-3;P19838;P19838-2 P19838-3 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 1 QMGYTEAIEVIQAAS(0.048)S(0.952)PVK 149.36 3.1839e-05 3959100.0 15041.0 14566.0 12070.0 17674.0 19048.0 11579.0 15827.0 17544.0 11745.0 16785.0 True False 14205.081433893609 15683.165362928039 11293.429340822358 15266.770710649424 16655.01994871943 13173.90214630332 16562.98686060554 17595.050135434445 14094.328182719057 16300.37343733258 0.8714574232612275 0.9621353414523034 0.6928325528393804 0.936590242508438 1.0217569562286595 0.8081963396084697 1.0161108838568997 1.079426198613136 0.864662900939371 1.0 13.992617396154046 -6.48648850655781 1.0138807022897152 0.9812484079607535 0.8593393617185436 0.17906441734379386 0.10036378037184464 0.937432936072335 2.0688125899879144 0.05088776672826856 0.06166904576550525 3.262206835892792e-07 6.48648850655781 -0.12190904624220988 QMNMS(ph)PPPGNAGPVIMSIEEK ddPTM_A459_Selumetinib_30min_R1 3 QMNMSPPPGNAGPVIMSIEEK 21 0 Q86U42-2;Q86U42;B4DEH8;G3V4T2;Q92843-2 Q86U42-2 PABPN1 Polyadenylate-binding protein 2 1 QMNMS(1)PPPGNAGPVIMSIEEK;QMNMS(1)PPPGNAGPVIMSIEEK;QMNMS(1)PPPGNAGPVIMSIEEK 98.23 0.00022205 53308300.0 7944.799999999999 8149.000000000001 9390.7 10031.6 8534.0 7679.5 8278.5 8230.6 5523.7 6555.84 True False 8129.898382110283 7194.911291632677 8115.494519422771 8279.769376453967 7762.101206800072 7602.2512024281095 7654.046079941413 8012.297751243341 9373.315464914054 7397.3459232892865 1.0990290931933682 0.9726341536875708 1.0970819268938763 1.1192891967356184 1.049308939624199 1.0276998373827178 1.0347016564203046 1.0831314142033 1.2671187155657766 1.0 12.852792027007759 -8.015490431295664 24.745456454319037 1.1474145982144524 1.056538618289437 0.14481244968219775 0.07200536822010375 907.7763519589877 1450134.3406550346 0.042992430433262355 0.01740126904525453 9.649605723121717e-09 8.015490431295664 -0.0908759799250154 QMNMS(ph)PPPGNAGPVIMSIEEK ddPTM_A459_Selumetinib_30min_R2 3 QMNMSPPPGNAGPVIMSIEEK 21 0 Q86U42-2;Q86U42;B4DEH8;G3V4T2;Q92843-2 Q86U42-2 PABPN1 Polyadenylate-binding protein 2 1 QMNMS(1)PPPGNAGPVIMSIEEK;QMNMS(1)PPPGNAGPVIMSIEEK;QMNMS(1)PPPGNAGPVIMSIEEK 98.23 0.00022205 33980000.0 111043.0 102691.0 117026.7 126113.0 127433.0 100231.7 106460.0 104575.0 82972.7 108015.0 True False 104871.67460034892 110567.06949639165 109497.32953103678 108936.19184294039 111423.72727452555 114037.70686221878 111410.60094648802 104879.29593667678 99569.55845094018 104896.32629332606 0.9997649899300745 1.0540604557228082 1.0438623867993693 1.0385129364618308 1.0622271647812207 1.0871468133529318 1.0621020285776817 0.9998376458237282 0.9492187378660869 1.0 16.67860462679233 -7.909963321293277 4.30519888941804 0.974324792098789 1.0509287817052106 0.6276483371740895 0.023967125976620433 0.13428666327153185 4.4934038296494485 0.014698212491436448 0.006580357686072878 1.2303726785866922e-08 7.909963321293277 0.07660398960642167 QMPSESLDPAFS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 QMPSESLDPAFSPR 14 0 Q15018 Q15018 FAM175B BRISC complex subunit Abro1 1 QMPSESLDPAFS(1)PR;QMPS(0.004)ES(0.027)LDPAFS(0.969)PR 108.63 0.0048238 13215000.0 1304.67 1079.09 1687.37 1626.71 1674.94 989.2099999999999 1532.7 1488.05 737.3399999999999 1045.1399999999999 True False 1335.0662725541017 952.7496411446684 1458.2344220599525 1342.6356356285564 1523.4419727346756 979.2594455308176 1417.0872050161513 1448.5820801323898 1251.2121268171206 1179.2938995257 1.1320895266998767 0.8078983886271731 1.2365318116598751 1.138508081970534 1.2918255350488868 0.8303777759934702 1.2016404100674898 1.2283469631403967 1.0609841425622106 1.0 10.2037075912317 -5.274125831998203 24.980167106196273 1.1305479575941282 0.969993935640213 0.14706153634841757 0.14712552018039568 1166.206675443526 2296311.4450450605 0.03717220219273883 0.07818220736365866 5.319541091466878e-06 5.274125831998203 -0.16055402195391522 QMPSESLDPAFS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 QMPSESLDPAFSPR 14 0 Q15018 Q15018 FAM175B BRISC complex subunit Abro1 1 QMPSESLDPAFS(1)PR;QMPSESLDPAFS(1)PR;QMPSESLDPAFS(1)PR;QMPSESLDPAFS(1)PR 159.54 0.0002975 10722500.0 77655.0 67398.6 80891.0 92176.0 95263.0 67115.0 73982.0 77837.0 64641.0 76278.0 True False 73339.24597759514 72567.85589934362 75686.56112746142 79621.4697875311 83295.21027797449 76359.4820406897 77422.30959255181 78063.49278339093 77571.00622044638 74075.655945955 0.990058677726767 0.9796451340544123 1.021746755542492 1.0748668880586394 1.124461325577002 1.0308309938747078 1.045178859422298 1.053834647651928 1.0471862210311247 1.0 16.176711875974433 -5.5056788460626125 3.7747953244420955 1.0574687446762145 0.9862069836324848 0.44894196132536335 0.030308413756455776 0.19214136144996175 5.949812314350449 0.008511046548936592 0.017596940338852354 3.121196806849778e-06 5.5056788460626125 -0.07126176104372972 QMQVS(ph)LTSK ddPTM_A459_Selumetinib_30min_R2 1 QMQVSLTSK 9 0 P55085 P55085 F2RL1 Proteinase-activated receptor 2;Proteinase-activated receptor 2, alternate cleaved 1;Proteinase-activated receptor 2, alternate cleaved 2 1 QMQVS(0.729)LT(0.067)S(0.204)K 133.05 0.0032161 3766300.0 37448.0 10165.0 21744.0 29226.0 11455.0 7347.0 31951.0 19040.0 15771.0 16455.0 True False 35366.79007622151 10944.622814373439 20345.014713077155 25245.368382337907 10015.92049100068 8358.982560574357 33436.78480970542 19095.403247758324 18925.64067855788 15979.901394775545 2.2132045250156733 0.6848992709023639 1.2731627192473627 1.5798200350968126 0.626782371402822 0.5230935006462077 2.0924274802244534 1.1949637720543982 1.1843402666267648 1.0 13.963970885580844 -4.7451516816650345 24.92802653865253 1.1490224708710477 2.2132076686033626 0.3456465357653028 0.4468230725142952 1145.2163171220827 1752634.7099585296 0.11350704220702662 2.98302506157907 1.798242751282102e-05 4.7451516816650345 1.064185197732315 QMQVSLTS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 QMQVSLTSK 9 0 P55085 P55085 F2RL1 Proteinase-activated receptor 2;Proteinase-activated receptor 2, alternate cleaved 1;Proteinase-activated receptor 2, alternate cleaved 2 1 QMQVS(0.274)LT(0.26)S(0.467)K 102.05 0.01648 3595200.0 36814.0 8943.7 16721.0 25194.0 9211.0 11839.0 31178.0 22257.0 15829.0 13453.0 True False 34768.02525811845 9629.65303147189 15645.189064448263 21762.533737925853 8053.8318326152175 13469.714786258312 32627.838778034944 22321.764185155287 18995.242299213278 13064.576934908258 2.661243868159179 0.7370811224465807 1.1975274164940364 1.6657664344091272 0.6164632710834714 1.0310104072537958 2.497427887684146 1.7085715286740002 1.4539500508782963 1.0 13.673372786733816 QMREEAERTRDELER ddPTM_A459_Selumetinib_30min_R1 1 QMREEAERTRDELER 15 3 A0A5K1VW66;P35240-4;P35240-6;P35240-5;P35240-3;P35240;P35240-2 A0A5K1VW66 NF2 Merlin 0 107.39 0.0024002 12014000.0 3004.0 3274.9 3730.8 3925.1 2746.5 3128.2 2664.8 2957.3 1880.3 2556.4 False True 3073.9873552335225 2891.473185540295 3224.177851817484 3239.654968252268 2498.079559933958 3096.7331481783467 2463.7919905572116 2878.862797335788 3190.731768321577 2884.538841444687 1.0656772275231186 1.0024039697423992 1.1177446479461144 1.123110190684666 0.866023894024885 1.0735626449832738 0.8541372212284896 0.9980322524948021 1.1061496979959322 1.0 11.494124974645333 -6.230591940818874 24.98951236509585 0.9809724155694639 1.074782619535556 0.2503355716365181 0.07981140433679779 1009.3529617412335 817676.8087437004 0.023322819006869767 0.030106655614241234 5.880416116388894e-07 6.230591940818874 0.09381020396609219 QMS(ph)FDLTK ddPTM_A459_Selumetinib_30min_R2 2 QMSFDLTK 8 0 Q9ULH0-2;Q9ULH0-4;Q9ULH0;H0Y8E4;E9PH70;A0A1W2PPB7;Q9ULH0-3 Q9ULH0-2 KIDINS220 Kinase D-interacting substrate of 220 kDa 1 QMS(1)FDLTK;QMS(1)FDLTK 100.93 0.017443 3340300.0 41376.0 15373.7 27010.0 33430.0 21886.0 15454.2 43484.0 32865.0 22913.0 21636.2 True False 39076.4875612514 16552.813355763206 25272.206006264434 28876.776330033408 19136.48501667752 17582.875770740196 45506.09216191136 32960.631708906374 27496.240242711112 21011.506688401252 1.8597660863046228 0.7877975435669576 1.202779333298129 1.3743315392976523 0.9107621504954341 0.8368212728145895 2.165770062888045 1.568694344375659 1.3086277272009987 1.0 14.35889199772164 -7.229568539553517 24.999608006175546 1.558164783466178 1.1451111483130576 0.15047575872376462 0.39841518579836344 1070.352089215751 839589.5043769608 0.1482414096548788 0.11481709441890353 5.8942894713630446e-08 7.229568539553517 -0.41305363515312044 QMSSQNS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 QMSSQNSPSR 10 0 Q15788-2;Q15788-3;Q15788;B5MCN7 Q15788-2 NCOA1 Nuclear receptor coactivator 1 1 QMSS(0.001)QNS(0.991)PS(0.009)R 106.79 0.011689 1320900.0 2832.1 2340.6 2606.9 2572.9 2186.9 2056.3 4485.6 8591.1 3746.2 4289.4 True False 2674.703219794568 2520.1164937847966 2439.1748921781104 2222.4665814999385 1912.162070865945 2339.536659767121 4694.189288047781 8616.098678666836 4495.544677573615 4165.553876800379 0.6421002581892052 0.604989532801466 0.5855583589406543 0.5335344703804543 0.45904149302102026 0.5616387949744038 1.1269063915345285 2.0684160938724876 1.0792189491560982 1.0 12.024292622314354 -7.393217136925068 3.8692912107682678 1.4551563312803284 0.5617780976715991 0.6437089963016932 0.2763197344216283 0.12953817127562034 3.3818227556535323 0.1168591835817429 0.07525794663265897 4.0437366392032144e-08 7.393217136925068 -0.8933782336087293 QMST(ph)PLLK ddPTM_A459_Selumetinib_30min_R1 1 QMSTPLLK 8 0 G3V434 G3V434 COQ6 1 QMS(0.034)T(0.966)PLLK 125.31 0.011976 26209000.0 6150.6 6533.3 7771.7 7412.7 6498.5 5761.5 7070.1 6626.2 3685.2 5271.2 True False 6293.897013015744 5768.378198751235 6716.345826892342 6118.211098612416 5910.711822403362 5703.544541023449 6536.796664829836 6450.451651069014 6253.51524364127 5947.809865836031 1.0581873252485126 0.9698323128794946 1.129213269824032 1.0286494082057267 0.9937627388451404 0.9589318874808638 1.0990258283770837 1.0845087177584702 1.0513979741620856 1.0 12.53814281402959 -7.2977179591138865 24.99083694792337 1.0657755105818745 1.0244176039707975 0.09730726346576057 0.051320310177538186 1316.2224514878103 906685.9658174036 0.021781944051252024 0.014686084369905495 5.038276999330289e-08 7.2977179591138865 -0.04135790661107697 QMWTSNLSK ddPTM_A459_Selumetinib_30min_R2 1 QMWTSNLSK 9 0 Q8NEL0 Q8NEL0 CCDC54 Coiled-coil domain-containing protein 54 0 139.88 0.012784 0.0 11465.0 12740.0 13022.0 13454.0 16032.0 11863.0 9638.5 13680.0 9305.5 11270.0 False True 10827.821198031403 13717.117034443449 12184.178697281583 11621.541990555474 14017.916832101522 13497.020568407988 10086.709348325425 13719.806535154092 11166.86001739398 10944.605817023421 0.9893294814866361 1.2533221628784124 1.1132587962492089 1.0618511241838546 1.2808060031086568 1.2332121223968158 0.9216146763948675 1.2535679004367684 1.0203071909656958 1.0 13.417932374628716 -8.445988937579882 10.011180245818496 1.0000232739672235 1.139461238823341 0.16775784508341374 0.1146559508240646 0.7707160083317 95.27519888837747 0.10615951246690011 0.027419264848118272 3.5810555870985962e-09 8.445988937579882 0.13943796485611748 QNAPPKGTDTQTPAVLS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 QNAPPKGTDTQTPAVLSPSK 20 1 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 QNAPPKGTDTQT(0.002)PAVLS(0.905)PS(0.093)K;QNAPPKGTDT(0.002)QT(0.042)PAVLS(0.916)PS(0.04)K 103.24 0.00032643 20929500.0 2968.6 1290.9499999999998 8114.299999999999 8350.5 3784.1000000000004 2915.7 1977.02 2075.59 2132.42 1265.55 True False 3037.7626041099293 1139.8049738536265 7012.422628659437 6892.241933298661 3441.828823137116 2886.3707052437844 1827.8917896920666 2020.538610733504 3618.5609942053366 1427.9956700009086 2.1272911871700537 0.798185175066323 4.910674994312115 4.826514588307033 2.410251582299914 2.0212741298031722 1.280040148644781 1.4149472951358586 2.534013982131356 1.0 10.479775889464893 -6.669056025475593 3.3069123882426306 1.633085973501188 3.15931332601403 0.26204303295847153 1.1882160081840216 0.38225152889335706 8.294019824727147 0.4595210593356102 0.4507000522604638 2.1426141787233704e-07 6.669056025475593 1.526227352512842 QNDVEIPS(ph)PTQK ddPTM_A459_Selumetinib_30min_R2 2 QNDVEIPSPTQK 12 0 Q07343-3;Q07343;E9PJ03;E9PNB0;E9PR34;Q07343-4;Q07343-2 Q07343-3 PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 QNDVEIPS(0.67)PT(0.33)QK;QNDVEIPS(0.98)PT(0.02)QK 140.77 0.0010472 23012000.0 103643.0 70057.0 92990.0 101036.0 99043.0 83831.0 105352.0 109020.0 92702.0 82258.0 True False 97882.93697580177 75430.14663124035 87007.12463985686 87274.72250317855 86600.33288434568 95377.95930794999 110251.07675102774 109337.23015076753 111244.99031029554 79882.99780804895 1.2253287891248763 0.9442578358475183 1.0891820165403219 1.0925318891122637 1.0840896719028728 1.1939707062212903 1.380156976781847 1.368717163237842 1.3925990932088752 1.0 16.285600854064597 -6.974710679377772 3.2530374507681006 1.3153042104980286 1.0797458877826243 0.35200892077643064 0.12369252608059546 0.22585858967638983 4.967275225348009 0.04551998029880195 0.03768313187007936 1.0599596195950363e-07 6.974710679377772 -0.23555832271540433 QNFRPPT(ph)PPYPGPGGGGWGSGSSFR ddPTM_A459_Selumetinib_30min_R2 1 QNFRPPTPPYPGPGGGGWGSGSSFR 25 1 Q8TAP9 Q8TAP9 MPLKIP M-phase-specific PLK1-interacting protein 1 QNFRPPT(1)PPYPGPGGGGWGSGSSFR 78.755 0.00032118 4847200.0 8025.7 8778.6 10627.0 12266.0 11818.0 12104.0 11131.0 8830.0 8529.8 8827.0 True False 7579.663723422643 9451.89039235206 9943.270389802745 10595.349639969781 10333.317185739514 13771.216130827823 11648.613555658063 8855.693838114812 10235.998342525072 8572.141574699708 0.8842205483159168 1.1026288250125138 1.159951723050149 1.2360213078189797 1.205453397577781 1.6065082466058365 1.3588918771521954 1.0330783458187387 1.1941004769142127 1.0 13.065439961954956 -4.63575534609491 1.1121685312282132 1.2537730301668806 0.6203503478314282 0.29696687745222883 0.1603474566789563 2.812641274360316 2.3431694185928715 0.05313831197703785 2.261027960336757 2.3133676274449242e-05 4.63575534609491 -0.6334226823354524 QNFSSQS(ph)LEHVEK ddPTM_A459_Selumetinib_30min_R2 1 QNFSSQSLEHVEK 13 0 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 QNFS(0.018)S(0.013)QS(0.97)LEHVEK 80.316 0.024684 12217000.0 69171.0 56222.0 67185.0 83800.0 71865.0 57914.0 82100.0 79167.0 64646.0 62298.0 True False 65326.7527334523 60534.04661777698 62862.39024549708 72386.29543693678 62836.67621874856 65891.12780905179 85917.81267806367 79397.36286319768 77577.00636015808 60499.294870357146 1.079793621949476 1.0005744157430976 1.0390598829325823 1.1964816382083803 1.0386348527433278 1.0891222443211728 1.4201456870228886 1.3123684008770162 1.2822795129496378 1.0 15.884630707176893 -7.141241287727429 7.8237570150668825 1.2792799538513289 1.0715609340501444 0.3814073066530108 0.11039174595534512 0.253128589378543 15.211343139446566 0.04063313896051737 0.03145664457006179 7.223683546918149e-08 7.141241287727429 -0.20771901980118446 QNGDDPLLTYR ddPTM_A459_Selumetinib_30min_R2 1 QNGDDPLLTYR 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 133.89 0.02401 3578100.0 16805.0 14096.0 19466.0 15530.0 22583.0 19532.0 16038.0 16906.0 11215.0 16236.0 False True 15871.045375745101 15177.117874216236 18213.578752978294 13414.787209255714 19745.921645418453 22222.35570615739 16783.798778694105 16955.193661061043 13458.313373281764 15767.22449380589 1.0065846009854174 0.9625738429853982 1.155154400201091 0.850802068209638 1.2523397287313047 1.4094018712606888 1.0644738891925825 1.075344215953914 0.8535626151938678 1.0 13.944641104266827 -6.268823575972709 24.98115299795299 1.1257293382740863 1.003076640280654 0.11077563460430406 0.15512632694161987 1330.6272704460837 4501575.576092178 0.050628129215074855 0.05851212244428873 5.384884889884877e-07 6.268823575972709 -0.12265269799343237 QNGSNDSDRY(ph)SDNEEDSKIELK ddPTM_A459_Selumetinib_30min_R2 1 QNGSNDSDRYSDNEEDSKIELK 22 2 G5E972;P42167;H0YJH7;P42167-2;P42167-3 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 QNGSNDS(0.006)DRY(0.564)S(0.43)DNEEDSKIELK 135.49 4.8435e-05 12172000.0 29124.0 12363.0 22405.0 24154.0 10730.0 8883.2 37762.0 21080.0 14179.0 13939.0 True False 27505.40467260936 13311.202346689508 20963.48669271955 20864.183532025934 9382.001472582917 10106.780166339202 39518.00782398347 21141.339310018146 17015.196194361306 13536.544852128609 2.031936877029899 0.9833530263519449 1.5486586068839465 1.5413226757598384 0.693086867813806 0.7466292378700995 2.9193570630964443 1.5617973080252965 1.2569822196308598 1.0 13.724571923424634 QNGSNDSDRYS(ph)DNEEDSK ddPTM_A459_Selumetinib_30min_R2 1 QNGSNDSDRYSDNEEDSK 18 1 G5E972;P42167;H0YJH7;P42167-2;P42167-3 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 QNGS(0.047)NDS(0.347)DRY(0.174)S(0.431)DNEEDS(0.001)K 66.845 0.016852000000000002 4584100.0 14626.0 5804.6 8877.9 10292.0 9249.2 7026.9 18667.0 12550.0 14337.0 9754.1 True False 13813.145472516977 6249.7941552692655 8306.705579526662 8890.211845309715 8087.23280710288 7994.791691152838 19535.05248795878 12586.51842223566 17204.80060925017 9472.473788804633 1.4582405589596368 0.6597847927175896 0.8769309648915816 0.9385311634028395 0.8537614341737269 0.8440025139580493 2.062296811108303 1.3287467142016764 1.8162943485348308 1.0 13.209525527333374 -7.2363152475108645 24.949624629458434 1.5792300676282793 0.9192164257597946 0.4590088812744465 0.32523174829638346 590.7279713694605 586625.6621965617 0.11546266834038874 0.08940106103824998 5.80343002763272e-08 7.2363152475108645 -0.6600136418684848 QNGSNDSDRYS(ph)DNEEDSKIELK ddPTM_A459_Selumetinib_30min_R1 2 QNGSNDSDRYSDNEEDSKIELK 22 2 G5E972;P42167;H0YJH7;P42167-2;P42167-3 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 QNGSNDS(0.013)DRY(0.443)S(0.544)DNEEDSKIELK;QNGS(0.005)NDS(0.03)DRY(0.148)S(0.817)DNEEDSKIELK 97.271 0.00021001 60575000.0 2999.0 4196.7 4311.9 3759.1 3241.2000000000003 4215.7 4258.4 3897.2 2139.2400000000002 4111.6 True False 3068.8708649618284 3705.3484130071 3726.367663571303 3102.6437520463455 2948.034032280338 4173.293885549341 3937.185459542491 3793.833596110313 3630.1340360922463 4639.363910375521 0.6614852648438666 0.7986759574346864 0.8032065894286965 0.6687649022547166 0.635439273407142 0.8995401020851466 0.8486476886922643 0.817748654643311 0.7824637399048988 1.0 12.179711299873908 -6.772719082181615 24.999886498256924 0.8569748163922651 0.7207424054413377 0.5177593331627275 0.07469380924479517 213.17183823231179 472462.6812650933 0.026863760111903917 0.023899792504156008 1.687644303494818e-07 6.772719082181615 -0.13623241095092742 QNGSNDSDRYS(ph)DNEEDSKIELK ddPTM_A459_Selumetinib_30min_R2 3 QNGSNDSDRYSDNEEDSKIELK 22 2 G5E972;P42167;H0YJH7;P42167-2;P42167-3 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 QNGSNDS(0.007)DRY(0.151)S(0.842)DNEEDSKIELK;QNGS(0.013)NDS(0.03)DRY(0.19)S(0.767)DNEEDSKIELK;QNGS(0.014)NDS(0.039)DRY(0.127)S(0.82)DNEEDSKIELK 105.95 7.1921e-05 59762000.0 166974.0 66234.0 121194.0 124381.0 59609.0 64137.0 178630.0 124801.0 100662.0 80484.0 True False 157694.25352988183 71313.93482412315 113396.50998605027 107440.09323080721 52120.384508778676 72971.28957228229 186936.6489486301 125164.15024808228 120797.21273127844 78160.21779745458 2.017576946094659 0.9124070637690266 1.4508213152617804 1.3746135343331423 0.666840318227415 0.9336116457784324 2.3917109524062514 1.6013792409385847 1.5455076269658554 1.0 16.254146867005055 -7.208765559977853 24.99998578015927 1.6847699928559166 1.203286161938557 0.1501786908348367 0.4683834331382892 545.332819512018 258825.2566903242 0.17633967293298852 0.13659201698983903 6.183501066397301e-08 7.208765559977853 -0.48148383091735947 QNGSNDSDRYS(ph)DNEEGK ddPTM_A459_Selumetinib_30min_R1 2 QNGSNDSDRYSDNEEGK 17 1 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 QNGSNDSDRYS(1)DNEEGK;QNGSNDSDRYS(1)DNEEGK 256.33 1.1377e-31 37511000.0 4587.4 5241.4 3631.1 3154.1 3814.7999999999997 3656.3 5035.9 4646.5 2446.46 4596.4 True False 4694.277494473456 4627.7344513392445 3138.0165642045854 2603.2956447898086 3469.75201355764 3619.520941654784 4656.038008573648 4523.259726040896 4151.46393763123 5186.39271272741 0.9051141620945318 0.892283848845997 0.6050480050428675 0.5019472664307352 0.6690106603464229 0.6978879429574391 0.8977411211356456 0.8721398429665409 0.8004530639269825 1.0 12.340515735599476 -7.25942529954314 24.141845234957582 0.8819285031059367 0.7037347842556697 0.3426201848275736 0.12195352498909373 151.81789420026067 1819789.2375365547 0.053957485590340686 0.03965965624915477 5.502685608519222e-08 7.25942529954314 -0.17819371885026702 QNGSNDSDRYS(ph)DNEEGK ddPTM_A459_Selumetinib_30min_R2 3 QNGSNDSDRYSDNEEGK 17 1 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 QNGS(0.002)NDS(0.27)DRY(0.004)S(0.724)DNEEGK;QNGS(0.001)NDS(0.005)DRY(0.017)S(0.976)DNEEGK;QNGSNDS(0.067)DRY(0.003)S(0.93)DNEEGK 133.9 0.002822 87419800.0 108944.0 72327.5 92510.2 90711.0 92574.2 80745.0 107572.9 99088.1 75960.4 75302.0 True False 102889.32861738605 77874.78668043249 86558.19444949023 78356.00531479699 80944.20137215161 91866.89081986887 112575.25300165746 99376.42996608188 91154.60251090788 73127.83560190735 1.406978994667558 1.064913053141167 1.1836559052656084 1.0714935656150237 1.1068863272912235 1.2562506474275132 1.5394309441139977 1.3589412177746705 1.2465103303088918 1.0 16.158133042100296 -6.988788840505682 12.093561062725163 1.327792875648505 1.1592060729631364 0.09628424865473217 0.15528274125135433 0.8086434332435747 860.2015959788497 0.053353411547870926 0.046526931467008655 1.0261507325008305e-07 6.988788840505682 -0.16858680268536852 QNGSNDSDRYS(ph)DNEEGKK ddPTM_A459_Selumetinib_30min_R1 1 QNGSNDSDRYSDNEEGKK 18 2 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 QNGS(0.013)NDS(0.046)DRY(0.182)S(0.758)DNEEGKK 76.417 0.016524 4278200.0 799.97 866.14 688.37 568.67 607.84 755.35 622.44 1042.7 430.08 667.77 True False 818.6077445293475 764.731926142438 594.8931349457494 469.3624597579724 552.8609793228682 747.7518648029267 575.4888496706814 1015.0442088330658 729.8143481996194 753.4847841306207 1.0864290318401937 1.0149268336251733 0.7895224262984206 0.622922280108852 0.7337387442544914 0.9923914597236243 0.7637697028410294 1.3471329882317866 0.9685853829705234 1.0 9.55743456811283 -7.741100589783637 24.999726120113355 1.1183945611506212 0.8524847193261361 0.3231469110169358 0.1637397137976862 265.7273950854751 326623.4863445362 0.08071355966973066 0.046528138519062893 1.8150952080177227e-08 7.741100589783637 -0.26590984182448507 QNGSNDSDRYS(ph)DNEEGKK ddPTM_A459_Selumetinib_30min_R2 1 QNGSNDSDRYSDNEEGKK 18 2 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 QNGSNDS(0.003)DRY(0.004)S(0.993)DNEEGKK 84.15899999999998 0.0092232 3330200.0 12312.0 8493.4 9390.2 11803.0 8803.7 6198.2 11074.0 8897.1 7246.1 6567.9 True False 11627.748328841037 9144.816469414594 8786.04475527673 10195.41103868932 7697.700499923418 7051.9457883424475 11588.962942714703 8922.989088005801 8695.522472950244 6378.26766154642 1.8230260857415748 1.433746113313379 1.3774970292084827 1.598460832892897 1.2068638239081204 1.1056208617360992 1.8169452204997216 1.3989674879593264 1.3633047301188366 1.0 12.638948925664481 -13.291016845530141 0.1618880243890824 1.572731481620432e-29 1.5743444535786395 0.31105673813577817 0.21605981796343168 120.36526335652593 1.5987168346154845 41.720691451972115 0.972559884195554 5.116619886737788e-14 13.291016845530141 1.5743444535786395 QNLWFANPGGSNS(ph)MPSQSR ddPTM_A459_Selumetinib_30min_R1 2 QNLWFANPGGSNSMPSQSR 19 0 M0QZ22;Q5PRF9;M0QX45 M0QZ22 SAMD4B Protein Smaug homolog 2 1 QNLWFANPGGS(0.09)NS(0.909)MPS(0.001)QSR;QNLWFANPGGS(0.061)NS(0.937)MPS(0.001)QSR 145.99 4.8264e-05 26189000.0 4154.5 3891.5 4518.7 4123.3 4729.2 4162.6 4054.8 3936.9 2477.2 3579.7 True False 4251.291766750224 3435.8813708907323 3905.08535944239 3403.243058927053 4301.4446950080755 4120.728023338404 3748.943171461793 3832.4806231465377 4203.627472470462 4039.1893642307714 1.0525111311684803 0.8506363681082494 0.9667992776035842 0.8425559566641341 1.0649277137387314 1.0201868869604633 0.928142464589735 0.9488242014809326 1.0407106707340537 1.0 11.979850068344243 -6.268055463884571 24.97857992599558 0.9952764639400012 0.9253531320248004 0.2172879352562207 0.06674436649848897 839.5268729220973 3169573.0514738327 0.020104330168032838 0.023338531011071268 5.394417258437221e-07 6.268055463884571 -0.06992333191520084 QNLWFANPGGSNS(ph)MPSQSR ddPTM_A459_Selumetinib_30min_R2 2 QNLWFANPGGSNSMPSQSR 19 0 M0QZ22;Q5PRF9;M0QX45 M0QZ22 SAMD4B Protein Smaug homolog 2 1 QNLWFANPGGS(0.007)NS(0.993)MPSQSR;QNLWFANPGGS(0.003)NS(0.995)MPS(0.002)QSR 199.97 2.0782e-15 14210600.0 107492.0 90354.0 102903.0 107316.0 118375.0 83011.0 83693.0 84484.0 79919.0 84445.0 True False 101518.02496456972 97283.86126609897 96282.33301231504 92699.37566957426 103503.67421407298 94445.01175116889 87584.8903345334 84729.8344529209 95905.03312343347 82006.85343554069 1.2379212311122907 1.1862894037577771 1.1740766652874348 1.1303857151699905 1.262134442158902 1.1516721809769823 1.0680191552938583 1.0332043104119406 1.169475831661034 1.0 16.323456862503377 -7.133772732281054 3.8680767334151196 1.0706117152760226 1.1934377590936898 0.5766768772551156 0.05248635957529928 0.1822884762506282 4.762510442384954 0.020409784044452345 0.015546530638521284 7.348983422496317e-08 7.133772732281054 0.12282604381766715 QNPEQS(ph)ADEDAEK ddPTM_A459_Selumetinib_30min_R1 2 QNPEQSADEDAEK 13 0 Q99613-2;Q99613;B5ME19;H3BPE3 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QNPEQS(1)ADEDAEK;QNPEQS(1)ADEDAEK 162.81 0.00036322 21131700.0 4122.0 3728.0 2667.0 2034.5099999999998 2575.7 2531.2 3435.6000000000004 3868.5 2044.11 4123.9 True False 4218.034579984212 3291.5240268998186 2304.8360487823597 1679.2210209826308 2342.72838977677 2505.7384261457173 3176.4499259825725 3765.8948133410518 3468.7053741125433 4653.242735187666 0.9064720712047913 0.7073613422333256 0.4953182500782232 0.36087114224332584 0.5034614618449058 0.5384929539990267 0.6826314694400885 0.8093054731195262 0.7454383043210511 1.0 12.184020731528895 -8.194488528016283 0.9790102317896676 0.9700517488021254 0.5757051732911141 0.423419873761238 0.1445382599309375 0.5342218293060088 1.031571994972391 0.14980085306204377 0.05308350084480972 6.3901561686260616e-09 8.194488528016283 -0.39434657551101127 QNPEQS(ph)ADEDAEK ddPTM_A459_Selumetinib_30min_R2 1 QNPEQSADEDAEK 13 0 Q99613-2;Q99613;B5ME19;H3BPE3 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QNPEQS(1)ADEDAEK 172.91 0.00016327 35162000.0 16858.0 11734.0 15497.0 17727.0 15508.0 15733.0 23682.0 21434.0 17267.0 12483.0 True False 15921.099847920914 12633.960069243272 14499.93989185783 15312.552019219327 13559.746396720968 17900.077940045783 24783.259924992755 21496.36939141028 20720.882480290333 12122.58335527093 1.3133421632443039 1.0421838067832294 1.1961097290003966 1.2631426462876323 1.1185525394490403 1.4765893882068284 2.0443876687568356 1.7732498726901806 1.70927943929384 1.0 13.565409553335048 -6.955402015892719 4.793637044829155 1.7053938533281232 1.1874765167640433 0.3885291236944759 0.25825338899302064 0.1686440316513992 8.725340635737043 0.08926111475635347 0.07694733729997928 1.1081485540419055e-07 6.955402015892719 -0.5179173365640799 QNS(ph)NSQSTPGSSGQR ddPTM_A459_Selumetinib_30min_R2 1 QNSNSQSTPGSSGQR 15 0 Q96HA1;Q96HA1-2;Q96HA1-3;A6NF01;A8CG34-2;A8CG34 Q96HA1;A8CG34-2 POM121;POM121B;POM121C Nuclear envelope pore membrane protein POM 121;Putative nuclear envelope pore membrane protein POM 121B;Nuclear envelope pore membrane protein POM 121C 1 QNS(0.992)NS(0.006)QS(0.002)TPGSSGQR 140.77 0.00034569 0.0 461.51 490.4 0.0 417.64 0.0 456.13 719.55 682.1 1036.7 592.7 True False 435.8611217709089 528.0121031154683 0.0 360.75671153081504 0.0 518.9577671641186 753.0105007612754 684.0847980722663 1244.0689678182075 575.5872109804596 0.757246014949602 0.9173450921816844 0.0 0.6267629034291768 0.0 0.9016144856313295 1.3082474495543281 1.188498953802311 2.1613909136359215 1.0 9.168890726849382 -7.155885006270129 2.608109508308676 1.456890243837757 0.46802128611030314 0.5595215673947196 0.3962383688346536 0.21429417865271416 2.8385272445856184 0.17169958674038166 0.12412206321019316 6.98417308520503e-08 7.155885006270129 -0.9888689577274538 QNS(ph)PVTQDGIQESPWQDR ddPTM_A459_Selumetinib_30min_R1 2 QNSPVTQDGIQESPWQDR 18 0 O75815 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 QNS(0.99)PVT(0.01)QDGIQESPWQDR;QNS(0.948)PVT(0.052)QDGIQESPWQDR 175.16 6.3575e-09 3017400.0 1411.63 1370.17 1622.38 1817.08 1476.94 1507.09 1526.7 1165.13 838.81 1005.1200000000001 True False 1444.518232446171 1209.7498594252488 1402.0697070954354 1499.7610888160384 1343.3510377749365 1491.9300429282343 1411.5397898467784 1134.2269675243795 1423.3993057415416 1134.136942697889 1.2736717922352003 1.066670005958444 1.2362437500362056 1.3223809509708777 1.1844698706131274 1.3154761006014193 1.2445937846703083 1.0000793773865406 1.255050648782813 1.0 10.147379135368109 -8.758343183832482 0.6703506241718246 1.004094192818782 1.227925343673775 0.2993750293364098 0.09798334125744017 1.36697042302493 1.2739014815330185 0.1029162241670018 0.038869878581741416 1.7444431317673927e-09 8.758343183832482 0.22383115085499283 QNS(ph)PVTQDGIQESPWQDR ddPTM_A459_Selumetinib_30min_R2 1 QNSPVTQDGIQESPWQDR 18 0 O75815 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 QNS(0.915)PVT(0.079)QDGIQES(0.006)PWQDR 249.49 6.6668e-33 4333000.0 17003.0 17200.0 20357.0 17461.0 22644.0 12265.0 16184.0 16761.0 13354.0 18971.0 True False 16058.041328401912 18519.184693283143 19047.25278302574 15082.781678094922 19799.25828007155 13954.392419415337 16936.588067987625 16809.771735067086 16025.173141935325 18423.257937422473 0.8716178964082034 1.005206829117114 1.033869951108689 0.8186815670347769 1.0746882200381105 0.757433482547639 0.9193047247949 0.9124212336473901 0.8698338370101193 1.0 14.169240587262621 -6.753844583365562 24.999999934823435 0.8880441088953132 0.9594417261689244 0.12888736529320433 0.08940838299261178 358.855082197356 1181251.8001100891 0.028407820186316646 0.027878131427582872 1.7626067000409423e-07 6.753844583365562 0.07139761727361127 QNS(ph)SSSDSGGSIVR ddPTM_A459_Selumetinib_30min_R2 2 QNSSSSDSGGSIVR 14 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 QNS(0.888)S(0.1)S(0.005)S(0.002)DS(0.004)GGS(0.002)IVR;QNS(0.416)S(0.416)S(0.163)S(0.002)DS(0.004)GGSIVR 192.23 0.00011013 20851300.0 53163.0 42405.8 59353.0 50640.0 61881.0 38801.0 51804.0 47386.0 43777.4 52175.0 True False 50208.41328835092 45658.188503861966 55534.29259866024 43742.74464112746 54106.955556840985 44145.48554959106 54212.9886476786 47523.88541482541 52534.10324275567 50668.572183069824 0.9909182581057089 0.901114567406697 1.0960303439775283 0.8633111760694822 1.0678602775966923 0.8712597108536964 1.0699529572651563 0.9379361479363896 1.0368183072723172 1.0 15.628803554503692 QNSNSQST(ph)PGSSGQR ddPTM_A459_Selumetinib_30min_R2 2 QNSNSQSTPGSSGQR 15 0 Q96HA1;Q96HA1-2;Q96HA1-3;A6NF01;A8CG34-2;A8CG34 Q96HA1;A8CG34-2 POM121;POM121B;POM121C Nuclear envelope pore membrane protein POM 121;Putative nuclear envelope pore membrane protein POM 121B;Nuclear envelope pore membrane protein POM 121C 1 QNSNSQS(0.004)T(0.996)PGSSGQR;QNSNS(0.002)QS(0.17)T(0.828)PGSSGQR 231.41 1.3264e-13 1770660.0 6016.0 2037.6 4007.2 5092.3 2583.02 4603.5 14123.8 19229.8 8171.200000000001 10516.1 True False 5681.654803956118 2193.8773680833565 3749.381114709474 4398.719955292524 2258.5179351082147 5237.590338587729 14780.584685778751 19285.755534335232 9805.668322403917 10212.472868890858 0.5563446656748066 0.21482332401257345 0.3671374370188835 0.4307203565447762 0.2211528945147156 0.5128621055672451 1.4473071190037854 1.888451091320235 0.9601659116543511 1.0 13.318044625169504 -7.21166567412108 4.643477997839758 1.4010784219522223 0.35905948937661214 0.7543162411152419 0.26211032194005823 0.09246420477839938 4.438788471414605 0.10046517362334133 0.07516595865993397 6.142346695255095e-08 7.21166567412108 -1.0420189325756102 QNSNSQSTPGSS(ph)GQR ddPTM_A459_Selumetinib_30min_R2 1 QNSNSQSTPGSSGQR 15 0 Q96HA1;Q96HA1-2;Q96HA1-3;A6NF01;A8CG34-2;A8CG34 Q96HA1;A8CG34-2 POM121;POM121B;POM121C Nuclear envelope pore membrane protein POM 121;Putative nuclear envelope pore membrane protein POM 121B;Nuclear envelope pore membrane protein POM 121C 1 QNSNSQS(0.001)T(0.006)PGS(0.133)S(0.86)GQR 113.11 0.0028437 333410.0 0.0 0.0 889.56 742.24 426.07 393.71 996.71 0.0 0.0 0.0 True False 0.0 0.0 832.3266780796961 641.1456315645821 372.543277485872 447.9399787564621 1043.0589899433974 0.0 0.0 0.0 0.0 QNSPAGNKENIKPNET(ph)SPSFSK ddPTM_A459_Selumetinib_30min_R1 1 QNSPAGNKENIKPNETSPSFSK 22 2 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 QNSPAGNKENIKPNET(0.487)S(0.487)PS(0.024)FS(0.002)K 110.94 0.00015084 36031000.0 1725.2 1144.3 1750.8 1872.1 1417.1 1343.7 1553.8 1761.5 1192.9 1156.1 True False 1765.3938033451632 1010.3248240293623 1513.050976456003 1545.172878669351 1288.9235552093255 1330.183597981985 1436.5956150284424 1714.7792978416085 2024.2641740311692 1304.496696367628 1.3533141235703423 0.7744939690860181 1.1598733677663535 1.184497349032685 0.9880619543141306 1.0196910438224047 1.101264279954594 1.314514097748513 1.5517587585064296 1.0 10.349277575202983 -7.743430100467237 4.956563426247436 1.3278426916360984 1.0701767674236706 0.191233859647978 0.18862192635044198 0.23745738524307947 15.246310099817853 0.0927313473282572 0.04844988356434417 1.8053852898289955e-08 7.743430100467237 -0.25766592421242773 QNSPAGNKENIKPNETS(ph)PSFSK ddPTM_A459_Selumetinib_30min_R2 1 QNSPAGNKENIKPNETSPSFSK 22 2 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 QNS(0.001)PAGNKENIKPNET(0.415)S(0.507)PS(0.065)FS(0.012)K 44.6 0.035958 35458000.0 42368.0 34501.0 32422.0 42448.0 39431.0 30475.0 26461.0 32298.0 23171.0 34024.0 True False 40013.35617254201 37147.11576180008 30336.0038184045 36666.50917311569 34477.325262387414 34672.65462549385 27691.48893147679 32391.98183277826 27805.84745183342 33041.638715031506 1.2109979325673967 1.1242516172450274 0.9181143853075259 1.1097061344126113 1.0434508275978085 1.0493624400571984 0.8380785580976408 0.9803382366154345 0.8415396007336589 1.0 15.011997619194897 -7.132341689330795 5.738139098639949 0.9139634948236315 1.0733699631826035 0.4692705866636 0.08414133141520945 0.22060579760604995 9.375412412864119 0.03255335589886595 0.02514046985901735 7.373238984566651e-08 7.132341689330795 0.159406468358972 QNSPVT(ph)QDGIQESPWQDR ddPTM_A459_Selumetinib_30min_R2 1 QNSPVTQDGIQESPWQDR 18 0 O75815 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 QNS(0.007)PVT(0.993)QDGIQESPWQDR 204.81 1.0926e-10 4275800.0 11960.0 12253.0 15841.0 14686.0 17421.0 10366.0 12056.0 12271.0 11279.0 13569.0 True False 11295.31107967339 13192.765700395244 14821.807306376713 12685.741465236926 15232.41823428397 11793.822406820978 12616.627888510791 12306.706578426594 13535.115161591162 13177.227713504059 0.8571841760082757 1.0011791544647333 1.1248046727755403 0.9627018475393382 1.1559653187653232 0.8950154511433871 0.9574569221097422 0.9339374598357019 1.0271595403728464 1.0 13.6857592609217 QNSSSS(ph)DSGGSIVR ddPTM_A459_Selumetinib_30min_R2 1 QNSSSSDSGGSIVR 14 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 QNS(0.002)S(0.19)S(0.19)S(0.568)DS(0.048)GGSIVR 236.75 2.4494e-19 17078000.0 55097.0 38296.0 43257.0 48074.0 61443.0 32489.0 54399.0 41276.0 33290.0 39743.0 True False 52034.92931076633 41233.18005895181 40473.89171466056 41526.23826772437 53723.98103261062 36964.06484422214 56928.66128957353 41396.10632639038 39948.9302003165 38595.516325284996 1.348211768232695 1.0683411956828468 1.0486682280279533 1.0759342592476053 1.3919746682444185 0.9577295075595597 1.4750071176603998 1.0725625737845264 1.0350666088678504 1.0 15.236145637638874 -10.499994550924672 5.415811353013202 0.9999995329793941 1.1620795685922787 0.07914759366755919 0.16745004160640317 9.031910297162207e-07 1.7042108599412515e-07 0.15484796571584344 0.037556040143178676 3.162317337387404e-11 10.499994550924672 0.16208003561288453 QNSSSSDS(ph)GGSIVR ddPTM_A459_Selumetinib_30min_R2 1 QNSSSSDSGGSIVR 14 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 QNS(0.021)S(0.192)S(0.192)S(0.155)DS(0.439)GGS(0.001)IVR 205.33 1.3341e-05 22110000.0 46243.0 46676.0 54550.0 53828.0 62566.0 28752.0 44554.0 45736.0 31914.0 44291.0 True False 43672.99918539607 50255.89911300488 51040.31238954926 46496.533541520694 54705.89973286329 32712.327015330586 46625.849282076146 45869.08418799763 38297.69175166423 43012.2037481619 1.0153629756127622 1.1684102355521029 1.1866472289676726 1.0810079347191714 1.271869259551741 0.7605359447951683 1.084014424256713 1.0664202293972864 0.8903912939662121 1.0 15.392458429806572 -6.742830247128681 24.999998255163646 0.972157414060046 1.144775420298577 0.4274108942604681 0.10626418001571893 252.42427162778793 339112.65913900436 0.0342404544674087 0.03418293866017396 1.807880635008183e-07 6.742830247128681 0.17261800623853096 QNTAWDTET(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 QNTAWDTETSPR 12 0 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 QNTAWDT(0.01)ET(0.878)S(0.112)PR 125.84 0.0065943 15843000.0 4358.1 5206.3 4490.6 3907.5 4544.8 3808.4 5488.3 5026.2 3313.1 5159.8 True False 4459.635250613585 4596.743975656793 3880.8011851001406 3225.1284778593526 4133.72364244961 3770.0909537505336 5074.313112344323 4892.88884860147 5622.088720749995 5822.110590708141 0.7659825730090025 0.7895322330347031 0.6665626021075152 0.5539449015287568 0.7100043151098625 0.6475471214455202 0.8715590391640321 0.8403977857119939 0.9656444399600769 1.0 12.50732652830533 -7.712482071055601 1.2787190102098527 0.9790143781647033 0.6865682080999327 0.7247690615259328 0.07069435949515425 0.26738625425581075 0.8040898126828095 0.06244887567587081 0.025075249429061402 1.9387326708461168e-08 7.712482071055601 -0.2924461700647706 QNTAWDTETS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QNTAWDTETSPR 12 0 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 QNTAWDTET(0.004)S(0.996)PR 155.14 0.00042332 35851000.0 125200.0 118190.0 145240.0 176190.0 161660.0 128300.0 143560.0 142840.0 136690.0 118890.0 True False 118241.88521531003 127254.79295925173 135895.4165253553 152192.6180552973 141350.8255412632 145972.16040855987 150235.8244587435 143255.64075156505 164031.8194377071 115457.33678668276 1.0241175529084996 1.1021802208582532 1.1770184581377763 1.3181719091311286 1.2242688899226981 1.2642952320843486 1.3012237129314437 1.2407668905116183 1.4207136939315501 1.0 16.817000327145635 -5.273379556270229 1.8789793333723193 1.2641617721098175 1.0309032984450175 0.35504699503228976 0.10152410164164812 0.39048266300906265 2.443740511635666 0.026888992590260664 0.11093225564202379 5.328689854203211e-06 5.273379556270229 -0.23325847366480001 QNTAWDTETS(ph)PRGER ddPTM_A459_Selumetinib_30min_R2 1 QNTAWDTETSPRGER 15 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 QNTAWDT(0.077)ET(0.258)S(0.665)PRGER 111.73 0.01511 2948200.0 15311.0 17722.0 18869.0 22955.0 20517.0 10411.0 7643.5 8330.5 7626.5 20252.0 True False 14460.07591478925 19081.220414788582 17654.989083013847 19828.48940041629 17939.47103569281 11845.020748351659 7998.937895307912 8354.740375811487 9152.013102214298 19667.27213898476 0.7352354618679563 0.9702016771794957 0.8976836725626969 1.0081972355033395 0.9121484112752436 0.6022706486514864 0.4067131343269664 0.42480422891238667 0.4653422720517016 1.0 14.263509248478943 -6.81714012137223 4.212237492078259 0.5244317804146963 0.9154236822897266 0.45866216402472326 0.17283676414022553 0.16266475467766925 5.885621946186736 0.05905431833484192 0.053120569658830004 1.5235611106256654e-07 6.81714012137223 0.3909919018750303 QNTQSDIGGS(ph)GK ddPTM_A459_Selumetinib_30min_R2 1 QNTQSDIGGSGK 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 QNTQS(0.001)DIGGS(0.999)GK 108.71 0.0087895 0.0 9179.8 8548.9 9268.8 8524.6 9615.5 7098.2 8486.5 8059.0 8542.8 9420.6 True False 8669.623465650991 9204.573140953968 8672.455499106396 7363.534774244774 8407.514926339338 8075.912618955882 8881.139065680729 8082.450355760726 10251.598705775428 9148.602800341687 0.9476445370791695 1.0061179113175829 0.9479540962017164 0.8048808036534012 0.9189944202217775 0.882748196112991 0.9707645265077014 0.8834628119890459 1.1205644107089823 1.0 13.159335712546802 -8.255633976917702 24.98634717626606 1.060282209079601 0.9206387271714028 0.4739800980464317 0.05897708691511885 377.4400193119874 1624513.9683494125 0.04352639303801336 0.015418485082260321 5.550933481502908e-09 8.255633976917702 -0.13964348190819809 QNVQVFEFQLTS(ph)EEMK ddPTM_A459_Selumetinib_30min_R1 1 QNVQVFEFQLTSEEMK 16 0 P52895;B4DK69;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 1 QNVQVFEFQLT(0.08)S(0.92)EEMK 188.0 8.9058e-07 8036800.0 1249.9 1709.8 1589.0 1756.8 1526.2 1482.6 1418.7 1665.2 1157.9 1602.8 True False 1279.0202381179693 1509.6158211355446 1373.222527752221 1450.0078592202974 1388.1554794724943 1467.6863900930946 1311.6863167980775 1621.033486668094 1964.8717303300284 1808.5349925940943 0.7072134315097719 0.834717507439659 0.7593010549287312 0.8017582546967813 0.7675579876291896 0.8115333107201319 0.7252756082516514 0.8963240928741693 1.0864438555936873 1.0 10.820605797034304 -8.026106871644052 3.819053670088965 1.0378069182796492 0.7773694763600751 0.8692010360627206 0.041920290174509885 0.06892465093603235 2.1373040674291 0.027259246122890348 0.010207779622991726 9.416578438538871e-09 8.026106871644052 -0.2604374419195741 QPAPGGGGGGGPS(ph)PCGPGGGGR ddPTM_A459_Selumetinib_30min_R1 2 QPAPGGGGGGGPSPCGPGGGGR 22 0 Q9H6S0;D6RF50;D6RA70 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 QPAPGGGGGGGPS(1)PCGPGGGGR;QPAPGGGGGGGPS(1)PCGPGGGGR 94.271 0.0002374 6421300.0 1486.39 1290.57 1350.5 1412.9 1625.28 1284.8899999999999 1244.37 1588.1 1083.03 1211.23 True False 1521.0199949885327 1139.4694644302847 1167.109517765496 1166.1635384177812 1478.2737109664893 1271.9651731867775 1150.5061690519647 1545.9784291241895 1837.8228086184745 1366.7031688793024 1.112911735059318 0.8337358765068573 0.8539597656179627 0.8532676040943376 1.0816348016363164 0.9306813667738766 0.84181129834899 1.1311735161863221 1.3447124807104167 1.0 10.416484226006698 -7.886021978112705 5.596481199559129 1.192285653335056 0.9267669551568591 0.4291101635218546 0.12083283673077524 0.17444208539441847 7.769603233576705 0.06614561569120661 0.031066906998533237 1.3001037826993002e-08 7.886021978112705 -0.26551869817819695 QPAPGGGGGGGPS(ph)PCGPGGGGR ddPTM_A459_Selumetinib_30min_R2 2 QPAPGGGGGGGPSPCGPGGGGR 22 0 Q9H6S0;D6RF50;D6RA70 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 QPAPGGGGGGGPS(1)PCGPGGGGR;QPAPGGGGGGGPS(1)PCGPGGGGR 200.14 2.1366999999999997e-22 6232300.0 8759.0 5473.0 8021.6 10977.9 10422.4 7721.4 6333.700000000001 7473.0 6251.5 8917.099999999999 True False 8272.209845055126 5892.761501531313 7505.498989257712 9482.69108206621 9113.044934561809 8784.952762109539 6628.229599988454 7494.7451927782495 7501.974681504316 8659.640153591801 0.9552602300251496 0.6804857242349895 0.8667218101602778 1.0950444722732535 1.0523583859061334 1.0144708794239863 0.7654162854837832 0.8654799806744414 0.8663148293053131 1.0 13.080091360489964 -5.528089877809681 24.96746164653191 0.9475671717496308 0.8068056560170473 0.19455091793420398 0.1115664561959521 209.89622299909428 1005647.6675062492 0.032481186244687356 0.056501024478022084 2.9642178772856456e-06 5.528089877809681 -0.14076151573258344 QPAQELS(ph)PTPGGTAHQALK ddPTM_A459_Selumetinib_30min_R1 2 QPAQELSPTPGGTAHQALK 19 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 QPAQELS(0.884)PT(0.116)PGGTAHQALK;QPAQELS(0.894)PT(0.1)PGGT(0.006)AHQALK 154.6 6.3121e-06 13602000.0 2979.2 2934.9 3628.2999999999997 2959.3999999999996 3082.4 2714.0 3303.4 3583.6 1609.8400000000001 2692.0 True False 3048.6095634859207 2591.2805436020058 3135.596788825285 2442.596344818162 2803.597464241919 2686.6996241148377 3054.221878417403 3488.551286826675 2731.7809019384194 3037.544422300538 1.0036427915602308 0.8530839992257475 1.0322801424087438 0.8041351846200223 0.9229815516964737 0.8844972288767445 1.0054904402366678 1.148477454754245 0.8993385847735049 1.0 11.568689792101186 -7.361793869196509 5.527637985933478 1.0282664871719698 0.9145407560684988 0.23544121059977974 0.08413513023455879 0.2921244397666914 13.095800802010647 0.03389948378856818 0.022571322664407912 4.347165063239765e-08 7.361793869196509 -0.11372573110347095 QPAQELS(ph)PTPGGTAHQALK ddPTM_A459_Selumetinib_30min_R2 1 QPAQELSPTPGGTAHQALK 19 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 QPAQELS(0.478)PT(0.478)PGGT(0.044)AHQALK 108.96 0.00071688 16617000.0 22595.0 16508.0 24758.0 22910.0 29974.0 21861.0 21350.0 24891.0 19484.0 23229.0 True False 21339.260354951537 17774.110518413836 23165.097234472232 19789.61847804561 26208.398149040113 24872.15431560039 22342.817304222423 24963.42868907312 23381.344428446002 22558.318413809848 0.9459597104493381 0.7879182389558259 1.026898229270978 0.8772647905320247 1.1618063752923953 1.1025712936286087 0.9904469337813984 1.1066174451102215 1.0364843690712473 1.0 14.461371907105415 -6.247734526961272 24.993583166566697 1.0696707477200689 0.9092099471874491 0.5214329016704455 0.0735537209293655 621.8792965217616 1134123.2187029535 0.02120160438444499 0.027218514166745828 5.652824118120297e-07 6.247734526961272 -0.1604608005326198 QPAQELSPT(ph)PGGTAHQALK ddPTM_A459_Selumetinib_30min_R1 1 QPAQELSPTPGGTAHQALK 19 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 QPAQELS(0.154)PT(0.659)PGGT(0.187)AHQALK 131.54 0.0006204 10134000.0 2441.0 1956.9 2332.6 2287.8 2297.9 1715.1 2426.7 2134.4 1195.5 1960.2 True False 2497.87055064082 1727.7852382618712 2015.8457320546447 1888.2786773247922 2090.0553507271948 1697.847651186203 2243.6520652526224 2077.7887784917007 2028.6761841346836 2211.8107639649024 1.1293328486037049 0.7811632289756268 0.9114006337689713 0.8537252409152105 0.9449521562959354 0.7676278996592969 1.0143960332441104 0.9394062151895158 0.917201515240874 1.0 11.111012242762726 -8.386064186198318 0.7798507091572896 0.992600173696216 0.9005836271461262 0.05179743363997358 0.10060684064636327 1.814483003614884 2.4845198572155374 0.09198007743790147 0.035227259507110656 4.11088960057402e-09 8.386064186198318 -0.09201654655008984 QPAQELSPT(ph)PGGTAHQALK ddPTM_A459_Selumetinib_30min_R2 1 QPAQELSPTPGGTAHQALK 19 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 QPAQELS(0.241)PT(0.757)PGGT(0.002)AHQALK 168.46 1.1881e-08 16522000.0 26510.0 23375.0 28214.0 31646.0 31158.0 24585.0 23787.0 26130.0 23615.0 24926.0 True False 25036.68032793827 25167.787337528694 26398.741957080525 27335.760207605043 27243.653483945804 27971.36058959039 24893.14263304631 26206.03397394562 28338.65985822994 24206.321614474346 1.034303382673698 1.0397196128502 1.0905722223113488 1.1292818728500833 1.1254768038633043 1.1555394923309914 1.028373621961681 1.0826111621302896 1.1707131843313456 1.0 14.563096244026946 -5.2971847194448145 3.765195857517651 1.103217553115749 1.0352819530194186 0.1880530581798734 0.05017511882025871 0.3309081035834444 10.090536009726613 0.013125897549421199 0.03278327901930204 5.044466944854255e-06 5.2971847194448145 -0.06793560009633048 QPAQS(ph)QNLSPLSGFSR ddPTM_A459_Selumetinib_30min_R2 1 QPAQSQNLSPLSGFSR 16 0 A6PVU7;Q9P2M7-2;Q9P2M7 A6PVU7 CGN Cingulin 1 QPAQS(0.588)QNLS(0.347)PLS(0.063)GFS(0.001)R 91.789 0.011303 4995000.0 6493.1 6427.6 6004.8 5909.5 6218.2 2250.7 5134.2 8974.6 6482.8 6252.2 True False 6132.239495938741 6920.576252008533 5618.457705531903 5104.615905543892 5437.014124586685 2560.7134951796243 5372.950473224294 9000.714600174992 7779.541144566299 6071.682740833528 1.0099736362537446 1.1398119018087014 0.9253542955639665 0.8407250713569273 0.8954707214890291 0.42174692000262287 0.8849195029723652 1.4824085816676518 1.2812825499341414 1.0 12.567880693303463 -7.740276846046217 23.01653676498623 1.2863838697369112 0.86835022425731 0.4181357426640484 0.2046199617027499 85.74920979458199 93261.74987786566 0.10261359781466074 0.059134062741922004 1.8185412388729958e-08 7.740276846046217 -0.4180336454796012 QPAQSQNLS(ph)PLSGFSR ddPTM_A459_Selumetinib_30min_R1 2 QPAQSQNLSPLSGFSR 16 0 A6PVU7;Q9P2M7-2;Q9P2M7 A6PVU7 CGN Cingulin 1 QPAQSQNLS(0.979)PLS(0.019)GFS(0.001)R;QPAQSQNLS(0.974)PLS(0.026)GFSR 218.83 1.054e-10 15793700.0 1169.33 1221.33 1395.2199999999998 1370.73 1476.82 1210.2 1456.37 1181.05 872.9 1079.85 True False 1196.5731138798988 1078.3361158190871 1205.7567873948733 1131.3577372888417 1343.2418917537482 1198.0264867736826 1346.5148383697856 1149.7247174089307 1481.2475459064542 1218.459266129731 0.9820378466000339 0.8849997253041327 0.9895749664449551 0.9285150260972158 1.1024101741376813 0.9832306422348033 1.1050963095769344 0.9435889646609802 1.2156726015235897 1.0 10.250842306314293 -6.250907752051023 24.78353422439116 1.0540955999352362 0.9449969498727809 0.3393805127560344 0.07644144357564889 732.6370424110326 1724074.6802679321 0.020897556737890816 0.02669749922580207 5.611671601904002e-07 6.250907752051023 -0.10909865006245523 QPAQSQNLS(ph)PLSGFSR ddPTM_A459_Selumetinib_30min_R2 1 QPAQSQNLSPLSGFSR 16 0 A6PVU7;Q9P2M7-2;Q9P2M7 A6PVU7 CGN Cingulin 1 QPAQS(0.002)QNLS(0.973)PLS(0.025)GFSR 161.75 4.4434e-05 5178200.0 7279.1 6229.6 9684.8 8624.3 5761.3 3979.8 5212.3 5174.0 5591.8 5933.4 True False 6874.556762546041 6707.390288678871 9061.69051201295 7449.655462252677 5037.513987324509 4527.981324972619 5454.682277976512 5189.055483398188 6710.316247946224 5762.087325175402 1.1930670908977892 1.164055646878745 1.572640260487046 1.2928744466790782 0.8742515868016915 0.7858231001097826 0.9466504011739301 0.9005513437337969 1.164563441902012 1.0 12.492375809554671 -6.2523553406231125 20.291723595724367 0.9324272046762166 1.3146153751260268 0.6214450449867623 0.13749203467224835 33.9245015079722 75777.74887705907 0.04258049142699909 0.05385388254881506 5.592997940089425e-07 6.2523553406231125 0.3821881704498101 QPAQSQNLSPLS(ph)GFSR ddPTM_A459_Selumetinib_30min_R2 1 QPAQSQNLSPLSGFSR 16 0 A6PVU7;Q9P2M7-2;Q9P2M7 A6PVU7 CGN Cingulin 1 QPAQSQNLS(0.173)PLS(0.791)GFS(0.036)R 152.59 0.00016745 5790700.0 5922.3 5337.4 6109.2 6992.1 8539.9 5887.8 6413.2 6922.5 6362.1 7389.9 True False 5593.162274845298 5746.761417554036 5716.14072319403 6039.763917954729 7467.041414325336 6698.791005873104 6711.426507514719 6942.643328918436 7634.697771926519 7176.534385733933 0.7793681426460962 0.8007711116075595 0.796504331471889 0.8415989659244211 1.040480127729743 0.9334297929637843 0.9351904619667409 0.9674089129593745 1.0638418715171711 1.0 12.809071606210196 -6.109729595659007 4.449541244887781 0.9823693833713202 0.7962388956726741 0.8412813133991 0.03973658711772174 0.09257543241242033 2.9955747486714537 0.01236213860320158 0.016377155113050414 7.767305810921616e-07 6.109729595659007 -0.18613048769864604 QPASAQSTPSTTPHS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 QPASAQSTPSTTPHSSPK 18 0 A0A087WT18;Q96A73-2;Q96A73 A0A087WT18 KIAA1191 Putative monooxygenase p33MONOX 1 QPASAQSTPS(0.005)T(0.044)T(0.073)PHS(0.741)S(0.137)PK 118.76 0.00065492 4675100.0 1038.3 967.15 1223.9 1383.9 1163.8 1111.1 1283.6 1073.6 522.94 837.44 True False 1062.4903698198957 853.9156283841628 1057.7011024014746 1142.2278440203597 1058.5344954855784 1099.9233427980823 1186.777018567711 1045.1246404557203 887.3909859735608 944.9335813563756 1.1244074618395685 0.9036779359226879 1.1193390977630728 1.2087916723001675 1.1202210571944515 1.164021857725949 1.2559369695213802 1.1060297369848244 0.9391040846487675 1.0 9.884069116764179 -4.372860084315214 22.056280134849867 1.1015821703934416 47.60519138768165 0.0 0.10760327364784339 8763.560948159798 1290934.8875865438 0.02717059912337919 39900.27701614825 4.237794721469689e-05 4.372860084315214 46.50360921728821 QPASAQSTPSTTPHS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 QPASAQSTPSTTPHSSPK 18 0 A0A087WT18;Q96A73-2;Q96A73 A0A087WT18 KIAA1191 Putative monooxygenase p33MONOX 1 QPASAQSTPS(0.004)T(0.011)T(0.093)PHS(0.446)S(0.446)PK;QPASAQSTPSTTPHS(0.769)S(0.231)PK 139.16 0.00021745 8901300.0 17252.5 14706.400000000001 19610.7 20691.0 23572.0 18938.1 20320.7 21092.1 17847.2 24822.0 True False 16293.67511722953 15834.333591470884 18348.968912515742 17872.850106034126 20610.67462364628 21546.65137204481 21265.652814703164 21153.474519014864 21417.138692432833 24105.3243646988 0.6759367710932324 0.6568811666628961 0.7611998343149038 0.7414482309231291 0.8550258155343354 0.8938544466797942 0.8821973308870212 0.8775436579477522 0.8884816635696179 1.0 14.557064222525426 -3.2202835806553383 0.19922941545680087 1.0016960259040049 1.2696063733163054e-17 0.9135872950725346 0.030525848384592633 7.5679747986921875 0.1634918171810509 0.06411293111612981 2.0663969132313262 0.0006021662620193644 3.2202835806553383 -1.0016960259040049 QPASAQSTPSTTPHSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 QPASAQSTPSTTPHSSPK 18 0 A0A087WT18;Q96A73-2;Q96A73 A0A087WT18 KIAA1191 Putative monooxygenase p33MONOX 1 QPASAQSTPS(0.005)T(0.003)T(0.031)PHS(0.234)S(0.727)PK 167.36 8.6951e-08 5140900.0 1670.3 1991.3 1987.5 2050.0 1889.6 1575.3 1992.3 1778.9 566.13 1752.0 True False 1709.2147401619682 1758.157670269746 1717.608416556034 1692.0059832659433 1718.6860136359765 1559.4539122579604 1842.0192069900688 1731.7177933184428 960.6812615007675 1976.8862659251652 0.8645994307427043 0.8893570159166156 0.8688453383291671 0.8558944499895645 0.8693904364961769 0.7888435157538767 0.9317780383931294 0.8759825100550306 0.4859567685099867 1.0 10.949014157092043 QPASAQSTPSTTPHSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QPASAQSTPSTTPHSSPK 18 0 A0A087WT18;Q96A73-2;Q96A73 A0A087WT18 KIAA1191 Putative monooxygenase p33MONOX 1 QPASAQSTPSTT(0.001)PHS(0.232)S(0.768)PK;QPASAQSTPS(0.002)T(0.006)T(0.024)PHS(0.267)S(0.701)PK 141.79 0.00020296 9737800.0 12763.0 12590.099999999999 14801.2 20884.8 19414.0 16282.5 15539.2 18017.0 13371.8 20206.2 True False 12053.683554337085 13555.720186447905 13848.906906328086 18040.254211710482 16975.039756637918 18525.266577181417 16261.803590340654 18069.426487125085 16046.533639308875 19622.794503987458 0.6142694686981364 0.690814969483236 0.705756099291256 0.9193519408280306 0.8650673966538506 0.9440687244325462 0.8287200677271613 0.9208385932723945 0.8177496653724897 1.0 14.260242891542752 -5.677644717005443 4.200430542108907 0.8938360314564049 0.6625111353468003 0.7889234935972381 0.05452975212850367 0.09075682065272195 2.979264152292185 0.014216065700167408 0.025238500475650693 2.100657664497782e-06 5.677644717005443 -0.2313248961096046 QPCPS(ph)ESDIITEEDK ddPTM_A459_Selumetinib_30min_R2 2 QPCPSESDIITEEDK 15 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QPCPS(0.999)ES(0.001)DIITEEDK;QPCPS(0.996)ES(0.004)DIITEEDK 214.34 3.4335e-07 7461800.0 27843.0 24578.0 25086.0 26979.0 23412.0 23743.0 29323.0 29036.0 23048.0 24189.0 True False 26295.597524360073 26463.053569274027 23471.99407157163 23304.413658629102 20470.775254064432 27013.382732505368 30686.5776024222 29120.489952831427 27658.24401492625 23490.60071943031 1.119409326242117 1.1265379666253084 0.9992079109393193 0.9920739761820053 0.8714453707917303 1.1499655992262974 1.3063343065994784 1.2396656135210855 1.1774174847750345 1.0 14.519795987061398 -6.985404451005619 24.958832735533488 1.204729850346998 1.0232626849049968 0.3658493304403154 0.09935495711692971 226.71106432834324 387681.3587076537 0.035686095944597276 0.03146004772453436 1.0341786052693469e-07 6.985404451005619 -0.18146716544200125 QPCPS(ph)ESDIITEEDKSK ddPTM_A459_Selumetinib_30min_R1 2 QPCPSESDIITEEDKSK 17 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QPCPS(0.5)ES(0.5)DIITEEDKSK;QPCPS(0.862)ES(0.138)DIITEEDKSK 81.226 0.0086416 13166900.0 3037.0 2643.8 3491.4 3836.7 2938.0 2734.6000000000004 3018.0 2767.26 2044.63 2507.99 True False 3107.7561910266986 2334.2626669307247 3017.2870568874146 3166.6923687787526 2672.2584187460307 2707.092406818142 2790.349830194259 2693.863275472707 3469.5877761332463 2829.9149463913564 1.098180068976857 0.824852587851562 1.06621121625404 1.1190061993972105 0.944289305285883 0.9565985049374595 0.9860189733802601 0.9519237597256626 1.2260395954859302 1.0 11.466542977908869 -8.237074388879098 24.99575445332505 1.1130198735347223 0.9912739518062296 0.19976941644787416 0.09570217745202508 1024.7983227695954 1051332.30521204 0.06246727442764346 0.0235836940606208 5.793294564831087e-09 8.237074388879098 -0.12174592172849275 QPCPS(ph)ESDIITEEDKSK ddPTM_A459_Selumetinib_30min_R2 2 QPCPSESDIITEEDKSK 17 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QPCPS(0.895)ES(0.105)DIITEEDKSK;QPCPS(0.991)ES(0.009)DIITEEDKSK 96.55 0.003271 23277000.0 70544.0 64702.0 60935.0 67514.0 67541.0 46392.0 50331.0 53874.0 35784.0 60538.0 True False 66623.44689000664 69664.43535027947 57014.50844101165 58318.47673185379 59055.895755798934 52782.07689535392 52671.4912289845 54030.76442067919 42941.799888498856 58790.110643386324 1.13324241374772 1.1849686042071852 0.9697976040027333 0.9919776658629985 1.0045209153291925 0.8978053675646844 0.8959243425902593 0.9190451222047062 0.7304255667926635 1.0 15.843285872610013 -5.355279491893792 0.5721647989464917 0.8748503423769866 1.2627257890510626 0.6198590352509892 0.07451124917745111 1.3908331153640128 0.5437915205602202 0.04342287995578222 0.32976196581265166 4.4128636440495484e-06 5.355279491893792 0.38787544667407603 QPCPSES(ph)DIITEEDKSK ddPTM_A459_Selumetinib_30min_R1 1 QPCPSESDIITEEDKSK 17 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QPCPS(0.456)ES(0.542)DIIT(0.001)EEDKS(0.001)K 79.461 0.0097121 9121400.0 1066.1 1264.4 1657.2 1609.9 1396.5 1426.0 1698.6 1594.1 960.3 1274.7 True False 1090.9380557305121 1116.3634601963872 1432.1613423480044 1328.7611865657764 1270.1868215721008 1411.6557347044065 1570.4732344492952 1551.8192896334413 1629.5589624630172 1438.320161629456 0.7584806810290424 0.7761578332682706 0.9957180470344834 0.9238285202513177 0.8831043709580774 0.981461410584107 1.0918801504319626 1.0789108927426865 1.132959827676273 1.0 10.490169131637948 -4.8130451527712195 0.3811381606662364 1.0892292420799636 0.5030046231528119 0.7224800192428764 0.06373261679905132 3.2590192346089504 0.382853317342906 0.06011379403559244 0.8816686639369798 1.5379947296037294e-05 4.8130451527712195 -0.5862246189271517 QPDISCILGTGGKS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QPDISCILGTGGKSPR 16 1 P57740;G3V1T4;P57740-2 P57740 NUP107 Nuclear pore complex protein Nup107 1 QPDISCILGTGGKS(1)PR 166.34 7.874600000000001e-05 6860300.0 19500.0 16780.0 18883.0 18187.0 22156.0 15688.0 15070.0 17930.0 15275.0 16426.0 True False 18416.26806468489 18066.97204379599 17668.088338255886 15709.899225675055 19372.56520284689 17848.879598515112 15770.784860638501 17982.17333152871 18330.426819159948 15951.738700126605 1.1544991057644847 1.1326020557027177 1.1075963987622026 0.9848393031632576 1.214448504142883 1.118930038540153 0.9886561682779653 1.1272861015072915 1.1491177961067318 1.0 13.96142606230698 -11.271873102034375 2.5704669263577418 0.9759852043290446 1.1061260293869655 0.18767626923916547 0.06763614238120798 21917648.711891826 15255627.1129769 3327600.313458152 0.01810518372104092 5.347205783773706e-12 11.271873102034375 0.1301408250579209 QPEDDSSQAFIS(ph)TQNGSPR ddPTM_A459_Selumetinib_30min_R1 1 QPEDDSSQAFISTQNGSPR 19 0 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 QPEDDSSQAFIS(0.671)T(0.304)QNGS(0.024)PR 183.21 2.2161e-13 8327600.0 1735.3 1671.4 1607.1 2006.7 1740.1 1701.9 1936.6 1894.3 1070.3 1499.4 True False 1775.7291136939841 1475.7117109872204 1388.8646471684028 1656.2675154242766 1582.7082622396076 1684.7804312015633 1790.520702834394 1844.057010446415 1816.2209283808886 1691.862595392803 1.0495705257209198 0.8722408752376262 0.8209086547279257 0.9789610101520908 0.935482743427014 0.9958139838243805 1.0583133096684398 1.0899567231216414 1.0735038018611749 1.0 10.724396689411366 -6.940251147547331 1.7127197619512255 1.0651279818154273 0.9198444441640496 0.47365195118401393 0.061046602685090136 0.30113059827725613 1.8000767392610946 0.02853995477286959 0.0226652770523115 1.1474898492925473e-07 6.940251147547331 -0.1452835376513777 QPEDDSSQAFIS(ph)TQNGSPR ddPTM_A459_Selumetinib_30min_R2 1 QPEDDSSQAFISTQNGSPR 19 0 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 QPEDDSSQAFIS(0.558)T(0.425)QNGS(0.017)PR 101.45 0.0011799000000000002 19967000.0 39279.0 37839.0 31691.0 37958.0 27568.0 19853.0 29057.0 32361.0 21916.0 23698.0 True False 37096.03042629526 40741.129628438386 29652.035562551904 32788.054918797694 24104.66137895302 22587.570542409514 30408.20807535318 32455.165152348058 26299.81238420358 23013.777165201507 1.6119053452202161 1.7702930438573081 1.2884471484058655 1.4247141911313714 1.0474013546720617 0.9814803706609079 1.3213045323708352 1.410249387546109 1.1427855668981968 1.0 14.490210166687895 -5.476876769244167 1.6142802149495534 1.1840614234218536 1.7110516139008929 0.6111734848411612 0.15610591477422273 0.30170767631449247 1.4690431431698445 0.04933498791823954 0.16133091202619387 3.3352103569887913e-06 5.476876769244167 0.5269901904790393 QPEDDSSQAFISTQNGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 QPEDDSSQAFISTQNGSPR 19 0 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 QPEDDSSQAFIS(0.058)T(0.058)QNGS(0.885)PR 191.9 3.0065000000000002e-15 7606100.0 530.5 585.15 431.16 529.32 696.0 448.52 442.97 596.43 338.12 472.57 True False 542.8596178266926 516.6403659711451 372.61084019235193 436.88419856698954 633.0469228887806 444.00829602357663 409.556416262807 580.6107389223222 573.7649446922786 533.2289627216069 1.018061012770069 0.9688902930819936 0.6987820734465394 0.8193182087055577 1.1871953084800602 0.8326785059786571 0.7680685875958917 1.088858219476448 1.076019842890333 1.0 9.058611333367473 -7.787943499935919 24.99673747172835 1.0618294023725863 0.8994555938550655 0.2255946126489281 0.13223123986781662 359.14487999636987 338713.85871315387 0.07571352544471546 0.03638838269098699 1.629508011659424e-08 7.787943499935919 -0.1623738085175208 QPEDDSSQAFISTQNGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QPEDDSSQAFISTQNGSPR 19 0 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 QPEDDS(0.134)S(0.134)QAFIS(0.022)T(0.19)QNGS(0.521)PR 111.57 0.00060837 18091000.0 37830.0 33859.0 44208.0 36023.0 39099.0 29024.0 33997.0 36506.0 23791.0 35820.0 True False 35727.5600454887 36455.87642615544 41363.70541003107 31116.605256858893 34187.03407050509 33021.792546360426 35577.927863777506 36612.22641610636 28549.864776080805 34785.783528463086 1.0270736036822348 1.0480107885546353 1.1890979939027584 0.8945207524619382 0.9827875241772814 0.9492898879032208 1.022772071086634 1.0525054405098797 0.8207336986594018 1.0 15.086210196442456 -5.771680454873441 24.99999184182092 0.9656326345363547 1.0840558113640464 0.3855237765174572 0.07361183069940096 219.6511539831887 536201.5128006035 0.02043463402776054 0.030688868459239637 1.6916851817007753e-06 5.771680454873441 0.11842317682769166 QPEKEEEEEAGES(ph)VEDIFSEVVGR ddPTM_A459_Selumetinib_30min_R1 3 QPEKEEEEEAGESVEDIFSEVVGR 24 1 Q8TDD1-2;Q8TDD1 Q8TDD1-2 DDX54 ATP-dependent RNA helicase DDX54 1 QPEKEEEEEAGES(0.998)VEDIFS(0.002)EVVGR;QPEKEEEEEAGES(0.999)VEDIFS(0.001)EVVGR;QPEKEEEEEAGES(0.981)VEDIFS(0.019)EVVGR 94.006 9.1331e-06 8902800.0 2067.38 2522.8900000000003 3167.08 3021.73 2456.3 2383.61 2754.62 2641.87 1591.79 2433.8 True False 2115.5459315787884 2227.5088659402604 2737.0079315251733 2494.041580397169 2234.1280986949887 2359.6330475447185 2546.836795642714 2571.799025596828 2701.1513702582592 2746.2019372195596 0.770353375295012 0.8111234777568983 0.9966521013732533 0.9081785088689819 0.8135338004156282 0.8592350823019849 0.9274033206098834 0.9364930490875304 0.9835953189200236 1.0 11.423222000137487 -1.5228787452927899 0.10733133681102681 1.05704643776318 0.33211299062313776 0.46450086129228496 0.057769014472321446 123.1555553337793 0.9301269602645714 0.6489724386213409 13.193860118919636 0.029999999999139826 1.5228787452927899 -0.7249334471400424 QPEYSPES(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 QPEYSPESPR 10 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 QPEYS(0.001)PES(0.999)PR;QPEYS(0.001)PES(0.999)PR 153.81 0.00058138 418120000.0 4875.4 4733.6 4187.6 4299.6 4955.7 4034.7 4447.1 4624.200000000001 2848.6000000000004 3632.5 True False 4988.987334123005 4179.387911409063 3618.946920840277 3548.7555734879256 4507.457809999896 3994.114581214491 4111.651666619252 4501.551194481504 4833.8661464877105 4098.766758546324 1.217192299054462 1.0196696122546218 0.8829355594080642 0.8658105675538692 1.0997107363090157 0.9744673987331377 1.003143606072744 1.0982696649169743 1.1793464793791042 1.0 12.000974180011072 -7.768903833718635 6.212828768079867 1.105113251676672 1.0009848567460562 0.11470754601603894 0.10311301942936403 0.29137039514353247 43.96895219421686 0.056080589303674246 0.028609775077797002 1.702535460866734e-08 7.768903833718635 -0.10412839493061576 QPEYSPES(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 QPEYSPESPR 10 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 QPEYS(0.1)PES(0.9)PR;QPEYS(0.223)PES(0.777)PR 141.34 0.0013192 272730000.0 83019.0 61115.0 70704.0 78376.0 83915.0 79193.0 71284.0 66628.0 71608.0 73150.0 True False 78405.13633138846 65802.32398430219 66154.98161669474 67701.05359385881 73372.8474903818 90101.11690752207 74598.84724656637 66821.87644914087 85931.60089469122 71037.96943347488 1.1037074533051334 0.9262979292492907 0.9312622833152218 0.9530263059849846 1.0328680292458734 1.2683515256147533 1.0501264020000762 0.9406501478299958 1.2096573364919139 1.0 16.11630272348234 -6.523677293523112 24.999399147860043 1.0943529009397213 0.9741460141330439 0.2287578236451263 0.09970671284981455 40.57182467371399 1270084.4888298172 0.03289058763630006 0.033167500175065236 2.994488892419582e-07 6.523677293523112 -0.12020688680667735 QPGLRQPS(ph)PSHDGSLSPLQDR ddPTM_A459_Selumetinib_30min_R1 2 QPGLRQPSPSHDGSLSPLQDR 21 1 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 QPGLRQPS(0.985)PS(0.014)HDGS(0.001)LSPLQDR;QPGLRQPS(0.988)PS(0.009)HDGS(0.002)LS(0.001)PLQDR 65.275 0.0056121 18063200.0 806.98 716.98 2659.5 2408.9 1404.9099999999999 1069.99 955.6300000000001 704.76 442.68 664.55 True False 825.7810638902619 633.0356482850412 2298.354507587811 1988.2308356533306 1277.8361385570065 1059.2268720731881 883.5460597178734 686.06747541689 751.1956279320299 749.8514657651647 1.1012595181735318 0.8442147240974958 3.0650797024748364 2.6514995654832743 1.7041190114272495 1.412582251862814 1.1782947691064174 0.9149378333438501 1.0017925712334157 1.0 9.55046103761476 -6.971335551557203 2.0552559297680624 1.006541812720442 1.9324273635391391 0.30373619909893024 0.6106816821280856 0.4570439294784452 3.897250456771478 0.2974405093356033 0.23637027804452587 1.0682292079352728e-07 6.971335551557203 0.9258855508186972 QPGQVIGATTPSTGS(ph)PTNK ddPTM_A459_Selumetinib_30min_R2 2 QPGQVIGATTPSTGSPTNK 19 0 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 QPGQVIGATTPS(0.001)T(0.003)GS(0.994)PT(0.001)NK;QPGQVIGATTPS(0.001)T(0.034)GS(0.904)PT(0.062)NK 313.36 5.0180999999999976e-117 25309000.0 56535.0 53898.0 58859.0 68714.0 64370.0 52044.0 58368.0 60204.0 41757.0 54804.0 True False 53393.01102753645 58031.80329061482 55072.07602083371 59355.03466173839 56283.26512489867 59212.58859160631 61082.22765399783 60379.18367269125 50109.56678806301 53221.666122107505 1.0032194577493276 1.0903793045011279 1.0347679814172066 1.1152419491257373 1.0575254257498605 1.1125654814291932 1.1476947661476002 1.1344850334854628 0.9415257063372585 1.0 15.699726054668643 -4.75572499155014 24.72301136555417 1.0782761758825539 1.0032193190140888 0.08516511974807917 0.06149674450282152 365.0184195611098 1579045.417547405 0.014871425867613622 0.1277987575548573 1.7549914639285826e-05 4.75572499155014 -0.07505685686846508 QPGTCS(ph)PDLAAPLDENGAVDR ddPTM_A459_Selumetinib_30min_R2 1 QPGTCSPDLAAPLDENGAVDR 21 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 QPGT(0.189)CS(0.811)PDLAAPLDENGAVDR 56.428 0.030029000000000007 4756800.0 14834.0 8933.3 13879.0 14952.0 14668.0 13724.0 14729.0 14611.0 13533.0 13793.0 True False 14009.585665206956 9618.455384913152 12986.040250312635 12915.511806361334 12825.274706416249 15614.35642593201 15413.927684959808 14653.515591018739 16239.978143613202 13394.760251482166 1.0459004418281215 0.7180759643569464 0.9694865758329414 0.9642212002213475 0.9574844540421765 1.165706301029482 1.1507430812921207 1.0939737118025152 1.212412752353384 1.0 13.70938113862499 -6.669765501442566 4.431335263468113 1.1320297366217342 0.9182157909098895 0.5140938015915338 0.09404253812055761 0.16564078979799723 5.832874157855096 0.03104616087689007 0.03065991555520032 2.1391168000120927e-07 6.669765501442566 -0.21381394571184476 QPGVDSLS(ph)PVASLPK ddPTM_A459_Selumetinib_30min_R2 2 QPGVDSLSPVASLPK 15 0 Q9UBW7;A0A087X151;Q9UBW7-2 Q9UBW7 ZMYM2 Zinc finger MYM-type protein 2 1 QPGVDS(0.003)LS(0.996)PVASLPK;QPGVDSLS(1)PVASLPK 245.74 3.8661999999999994e-21 20901000.0 68569.0 61581.0 73819.0 76475.0 75728.0 62459.0 73350.0 72775.0 59546.0 68895.0 True False 64758.20948345532 66304.06468587604 69069.56590805025 66058.97307326668 66214.37162309041 71062.16030364957 76760.92034026764 72986.76320145019 71456.86385425193 66905.82233929283 0.9679009571850632 0.9910059000490995 1.0323401386173037 0.9873426671040435 0.9896653132414106 1.0621222162591337 1.1472980625063933 1.0908880669804741 1.0680216064288075 1.0 16.0298441433986 -6.854857869860285 4.45135722818233 1.0865127088235664 0.995295023219643 0.5298474214934734 0.03726617887045488 0.15597012466647278 5.503551676885334 0.0131933755602051 0.011689873595365888 1.396825420764799e-07 6.854857869860285 -0.0912176856039234 QPGYQPPNPHPGPS(ph)SPPAAPASK ddPTM_A459_Selumetinib_30min_R2 1 QPGYQPPNPHPGPSSPPAAPASK 23 0 Q9BUL9 Q9BUL9 RPP25 Ribonuclease P protein subunit p25 1 QPGYQPPNPHPGPS(0.907)S(0.093)PPAAPASK 131.75 4.8189e-06 32962000.0 59948.0 47188.0 52602.0 69832.0 66165.0 50746.0 65276.0 64354.0 52330.0 53305.0 True False 56616.330150857924 50807.1678666654 49217.644588727206 60320.761133080836 57852.76117739511 57735.80087367719 68311.46334194003 64541.259485621784 62797.462222366 51765.94614697727 1.0936983550944692 0.9814785906242368 0.9507726266411752 1.1652595117611522 1.1175833821936867 1.1153239759155549 1.3196216514228416 1.2467899128583877 1.2131037273822316 1.0 15.659715723001392 -6.195130663786595 1.267194412838182 1.202877060011662 1.009813567787549 0.3362583437691544 0.09274226021854157 0.44770322507733407 1.4630413048318556 0.03621952997045558 0.05551199619653707 6.380714842588018e-07 6.195130663786595 -0.193063492224113 QPGYQPPNPHPGPSS(ph)PPAAPASK ddPTM_A459_Selumetinib_30min_R1 2 QPGYQPPNPHPGPSSPPAAPASK 23 0 Q9BUL9 Q9BUL9 RPP25 Ribonuclease P protein subunit p25 1 QPGYQPPNPHPGPS(0.233)S(0.766)PPAAPASK;QPGYQPPNPHPGPS(0.242)S(0.757)PPAAPAS(0.001)K 116.05 7.1597e-06 50037000.0 7932.0 7747.3 7712.4 7622.299999999999 8984.6 7684.9 9393.2 9333.8 4478.3 7257.2 True False 8116.80016701475 6840.242514377943 6665.098441180759 6291.208393291702 8171.944516359962 7607.596883330914 8684.663361491295 9086.237303544709 7599.348017909122 8188.732311114218 0.9912157167475315 0.8353237417584127 0.813935318429509 0.7682762305897963 0.9979498908846404 0.9290323085791249 1.0605626159868446 1.1096024339704385 0.9280249651823214 1.0 12.999424411738904 -6.3465731123511455 7.203633811053698 1.0096293303298574 0.8485286906711534 0.5053265757487997 0.07355390460758511 0.22418914988916494 16.50560835133154 0.02371810708431367 0.026917662610763622 4.502221811698292e-07 6.3465731123511455 -0.16110063965870391 QPGYQPPNPHPGPSS(ph)PPAAPASK ddPTM_A459_Selumetinib_30min_R2 3 QPGYQPPNPHPGPSSPPAAPASK 23 0 Q9BUL9 Q9BUL9 RPP25 Ribonuclease P protein subunit p25 1 QPGYQPPNPHPGPS(0.249)S(0.748)PPAAPAS(0.002)K;QPGYQPPNPHPGPS(0.248)S(0.748)PPAAPAS(0.004)K;QPGYQPPNPHPGPS(0.111)S(0.871)PPAAPAS(0.018)K 111.27 9.753e-06 81837000.0 70883.0 61046.0 74295.0 90743.0 89731.0 60243.0 75436.0 78672.0 64716.0 73550.0 True False 66943.6066271312 65728.03190617212 69514.94058627967 78383.64685959365 78458.18957468208 68540.9264184947 78943.92347359828 78900.92249514935 77661.00831612149 71426.42039415035 0.9372387172382185 0.9202201586397166 0.973238476780404 1.0974041037903262 1.0984477332299243 0.9596018677719993 1.105248212607664 1.1046461807795025 1.0872868595061462 1.0 16.12417020059869 -5.608853652125088 4.3267529629249335 1.0674395811937878 0.9320139285605239 0.596105778279592 0.04646338941529377 0.14096054537141703 4.851034430674506 0.013081789553136942 0.02376263898514136 2.461196834681357e-06 5.608853652125088 -0.1354256526332639 QPLFVPTTSGPS(ph)TPPGLVLPHTEFQPAPK ddPTM_A459_Selumetinib_30min_R2 2 QPLFVPTTSGPSTPPGLVLPHTEFQPAPK 29 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 QPLFVPT(0.185)T(0.032)S(0.008)GPS(0.388)T(0.388)PPGLVLPHTEFQPAPK;QPLFVPT(0.055)T(0.278)S(0.064)GPS(0.325)T(0.278)PPGLVLPHTEFQPAPK 70.718 0.00019667 3411300.0 30749.9 25857.7 30855.5 34351.4 35018.8 28404.9 29682.0 29109.6 27290.5 29694.0 True False 29040.943659602774 27840.90244438998 28870.29072292827 29672.680060529747 30619.425271955904 32317.41714099068 31062.271813767213 29194.304116646294 32749.3625602805 28836.657065722582 1.0070842675492724 0.9654691381506828 1.0011663507711392 1.0289916751758623 1.0618229846188536 1.1207060883421744 1.077180053949116 1.0124025142757909 1.1356851276359927 1.0 14.815616307157292 -5.980401892568377 2.0941653227633323 1.0718397943133797 0.9866853384600259 0.4243514957112431 0.04025183458410763 0.28598578773588257 2.525354230088261 0.012401292628587749 0.01982625309811691 1.0461599920563408e-06 5.980401892568377 -0.0851544558533538 QPLLGPGLGPGLGAS(ph)WR ddPTM_A459_Selumetinib_30min_R2 2 QPLLGPGLGPGLGASWR 17 0 Q05BS2;Q96SL1-2;Q96SL1 Q05BS2 DIRC2 Disrupted in renal carcinoma protein 2 1 QPLLGPGLGPGLGAS(1)WR;QPLLGPGLGPGLGAS(1)WR 132.5 0.00070206 5410700.0 20961.5 7392.7 16578.0 20111.2 15807.3 6828.2 26821.0 18529.1 17407.7 10476.0 True False 19796.543745532927 7959.696318722919 15511.389528761652 17372.019866244926 13821.445654945004 7768.722569771853 28068.229644803247 18583.016613342355 20889.72641177681 10173.53066008318 1.9458872644092537 0.7823927193686602 1.5246810617696445 1.7075704046782605 1.3585692240723044 0.763621089800533 2.758946778912421 1.8266044733373241 2.0533408813264455 1.0 13.31253282391973 -7.25020345259698 24.990441792428552 1.9786067815924957 1.3464263429810672 0.21068922708970061 0.5267626325538783 1010.3157906528492 2247102.0058921687 0.19338939230941232 0.14840294306546536 5.6207794857990156e-08 7.25020345259698 -0.6321804386114285 QPLLLS(ph)EDEEDTK ddPTM_A459_Selumetinib_30min_R1 4 QPLLLSEDEEDTK 13 0 Q99613-2;Q99613;B5ME19;H3BPE4 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QPLLLS(1)EDEEDTK;QPLLLS(1)EDEEDTK;QPLLLS(1)EDEEDTK;QPLLLS(1)EDEEDTK 159.69 0.00036421 69667000.0 7718.0 8398.7 9405.3 9531.900000000001 7471.9000000000015 7985.0 8310.3 9002.1 5295.48 8276.7 True False 7897.814383386262 7415.376299550297 8128.111919614829 7867.332600923241 6796.0679642710875 7904.678149799914 7683.44738033908 8763.33506505816 8986.04279344335 9339.095066885171 0.8456723405022996 0.7940144357073684 0.8703318535042779 0.8424084501312609 0.7277009084497682 0.8464072903410681 0.8227186173083585 0.9383494870002387 0.9621963080027225 1.0 13.189067048112353 -7.874408233658858 2.23777541734275 0.9823009594321057 0.8183596646221456 0.7569586367158772 0.03818320506606194 0.15652442363346322 1.5132073710660952 0.02875723156654138 0.010981690367957455 1.3353397167819162e-08 7.874408233658858 -0.16394129480996011 QPLLLS(ph)EDEEDTK ddPTM_A459_Selumetinib_30min_R2 4 QPLLLSEDEEDTK 13 0 Q99613-2;Q99613;B5ME19;H3BPE4 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QPLLLS(1)EDEEDTK;QPLLLS(1)EDEEDTK;QPLLLS(1)EDEEDTK;QPLLLS(0.998)EDEEDT(0.002)K 184.01 0.00011051 43458000.0 106035.0 82877.8 95495.1 96508.1 102914.6 75528.3 95393.1 100084.0 69557.2 78213.5 True False 100141.99919173645 89234.260765871 89351.04923320333 83363.5302942416 89985.54787980263 85931.63774735645 99829.0681678417 100375.22787020191 83470.58359055137 75955.27303192191 1.3184337991866546 1.174826410384547 1.1763640056385756 1.0975344695187417 1.1847175882309604 1.1313452551377408 1.3143138610782992 1.3215044046779605 1.098943894987659 1.0 16.21286250376246 QPLLLS(ph)EDEEDTKR ddPTM_A459_Selumetinib_30min_R1 14 QPLLLSEDEEDTKR 14 1 Q99613-2;Q99613;B5ME19;H3BPE4 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QPLLLS(0.999)EDEEDT(0.001)KR;QPLLLS(0.997)EDEEDT(0.003)KR;QPLLLS(0.987)EDEEDT(0.013)KR;QPLLLS(1)EDEEDTKR;QPLLLS(1)EDEEDTKR;QPLLLS(1)EDEEDTKR;QPLLLS(0.998)EDEEDT(0.002)KR;QPLLLS(1)EDEEDTKR;QPLLLS(1)EDEEDTKR;QPLLLS(1)EDEEDTKR;QPLLLS(0.991)EDEEDT(0.009)KR;QPLLLS(1)EDEEDTKR;QPLLLS(0.994)EDEEDT(0.006)KR;QPLLLS(1)EDEEDTKR 190.18 0.00018087 8038245900.0 44891.40000000001 48911.51000000001 55923.39 55462.299999999996 45906.3 43900.05 47488.14 48248.74 30281.179999999997 44887.090000000004 True False 45937.28227654131 43184.92767085589 48329.300803192724 45776.85046131254 41754.08327041556 43458.455355056205 43906.07136687914 46969.026681204865 51384.95081011754 50648.78523878246 0.9069769800000358 0.8526350132043958 0.954204539661621 0.9038094446984009 0.8243846930102461 0.8580354918715697 0.8668731374283716 0.9273475456473543 1.0145347132782048 1.0 15.628240047371508 -8.091155227918987 3.109344207095875 1.0074224230285904 0.8808114306444286 0.6827167366164433 0.03403210432931993 0.16158768905967033 2.8481624771146694 0.028982690340630845 0.009685856043951507 8.106712514936958e-09 8.091155227918987 -0.12661099238416185 QPLLLS(ph)EDEEDTKR ddPTM_A459_Selumetinib_30min_R2 11 QPLLLSEDEEDTKR 14 1 Q99613-2;Q99613;B5ME19;H3BPE4 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QPLLLS(1)EDEEDTKR;QPLLLS(0.924)EDEEDT(0.076)KR;QPLLLS(0.997)EDEEDT(0.003)KR;QPLLLS(1)EDEEDTKR;QPLLLS(1)EDEEDTKR;QPLLLS(0.914)EDEEDT(0.086)KR;QPLLLS(0.993)EDEEDT(0.007)KR;QPLLLS(1)EDEEDTKR;QPLLLS(0.998)EDEEDT(0.002)KR;QPLLLS(0.963)EDEEDT(0.037)KR;QPLLLS(0.992)EDEEDT(0.008)KR 139.46 0.00029285 5572692300.0 1586732.0999999999 1369242.3 1445268.1 1618493.4 1469661.9 1219132.1 1468754.7000000002 1485677.8 1163370.2 1458220.0 True False 1498547.882073864 1474258.7816020832 1352281.123934925 1398051.8068631536 1285029.8331779146 1387056.480595669 1537054.7038322247 1490000.8764307983 1396076.7472793097 1416117.3996894343 1.0582087914480165 1.041056893959074 0.9549216217747843 0.9872428706615407 0.9074317097295265 0.9794784534812307 1.0854006201529003 1.0521732709149447 0.9858481702050128 1.0 20.433509442745702 -7.212135074220434 24.990864638207043 1.0352033710581683 0.9852578974835967 0.1630726266502902 0.04683253743544086 648.1573402540768 328531.3098669705 0.019215448573107443 0.014884199113514877 6.135711426582153e-08 7.212135074220434 -0.049945473574571575 QPLLLSEDEEDT(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 QPLLLSEDEEDTKR 14 1 Q99613-2;Q99613;B5ME19;H3BPE4 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 QPLLLS(0.007)EDEEDT(0.993)KR 122.96 0.0022888 0.0 33233.0 25448.0 33805.0 34775.0 30706.0 24337.0 28810.0 31820.0 27616.0 34346.0 True False 31386.042902239646 27399.779771783105 31630.023104101056 30038.58500977899 26848.437764877093 27689.20084071024 30149.722085931997 31912.590931915434 33139.9716555104 33354.341738375006 0.9409882272126875 0.8214756563538765 0.9483030231026842 0.900589951539018 0.8049458141153268 0.8301528196208747 0.9039219638157028 0.956774718632783 0.9935729481772994 1.0 15.025586948957052 -7.81213257277027 2.396309708245923 0.9933608185753189 0.8731779261242937 0.5453949916142988 0.04526666528640643 0.23924369796759984 2.7120388682443117 0.032157285606423586 0.013286776465554874 1.541229905162306e-08 7.81213257277027 -0.1201828924510252 QPLLLSEDEEDTKR ddPTM_A459_Selumetinib_30min_R1 2 QPLLLSEDEEDTKR 14 1 Q99613-2;Q99613;B5ME19;H3BPE4 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 ; 184.51 0.00010591 17438700.0 4496.0 3951.5 4820.299999999999 5314.299999999999 3942.8999999999996 4098.0 4178.4 4449.200000000001 2651.1000000000004 3979.3999999999996 False True 4600.748052306897 3488.856542997488 4165.729736012603 4386.257266765952 3586.265391175533 4056.777840686292 3863.2199239508604 4331.1927629616175 4498.723071316989 4490.194752638473 1.0246210478072164 0.7769944813523754 0.9277392107691517 0.9768523434731988 0.7986881613694408 0.9034748077023828 0.8603680100246883 0.9645890660792776 1.001899320441169 1.0 12.132562304811678 -7.924403962470397 4.665557525458444 0.9962653726093529 0.8921537033698878 0.27776047072782173 0.07018594118065438 0.25608354378064857 10.271319275275175 0.03953590260428294 0.017867886378971198 1.1901344799562656e-08 7.924403962470397 -0.10411166923946513 QPLSEASNQQPLS(ph)GGEEK ddPTM_A459_Selumetinib_30min_R1 1 QPLSEASNQQPLSGGEEK 18 0 Q9NQW6;Q9NQW6-2;C9JJT6 Q9NQW6 ANLN Actin-binding protein anillin 1 QPLSEASNQQPLS(1)GGEEK 278.08 7.407199999999997e-67 7393100.0 1230.0 1193.2 1361.0 1260.6 1176.8 1331.0 1217.1 1389.6 727.79 1126.8 True False 1258.656606836628 1053.4995892963689 1176.1836754378671 1040.4598743927065 1070.3586477809147 1317.6113484513066 1125.2931671071678 1352.7432939430594 1235.006474321524 1271.4357559614589 0.9899490406299237 0.8285905004297391 0.9250830566334339 0.8183346028411097 0.8418503591410407 1.0363176765112523 0.8850570403034024 1.0639493876118937 0.9713479179194648 1.0 10.312242850978437 -6.757501272181528 24.999928194103372 0.9886889086801843 0.8768572631356394 0.4250413846176547 0.06418443485331272 96.95993700162944 615521.8262337215 0.0207345855291581 0.020007228465560658 1.7478281424868654e-07 6.757501272181528 -0.11183164554454494 QPLSEASNQQPLS(ph)GGEEK ddPTM_A459_Selumetinib_30min_R2 4 QPLSEASNQQPLSGGEEK 18 0 Q9NQW6;Q9NQW6-2;C9JJT6 Q9NQW6 ANLN Actin-binding protein anillin 1 QPLSEASNQQPLS(1)GGEEK;QPLSEASNQQPLS(1)GGEEK;QPLSEASNQQPLS(1)GGEEK;QPLSEASNQQPLS(1)GGEEK 329.78 3.691399999999998e-144 27880600.0 112876.0 92499.0 100145.0 114189.0 118678.0 79987.0 111880.0 112238.0 87091.0 89781.0 True False 106602.8037984294 99593.3758688369 93701.77972963193 98636.26121298797 103768.60864521873 91004.48320030775 117082.6416860142 112564.5939979989 104511.63352585676 87188.78925094746 1.222666408310871 1.1422727247901845 1.0746998614688723 1.1312952279804265 1.1901599911721574 1.0437635845404152 1.3428634884357211 1.2910443528928313 1.198682014324692 1.0 16.411855024507773 -7.254260460279112 24.996042444190262 1.2324011607069112 1.1342273321475262 0.1034314976764138 0.09671541226747435 915.6757036904028 3188269.668749248 0.036023406107902146 0.027301970477508295 5.568516870166831e-08 7.254260460279112 -0.09817382855938495 QPLTSPGS(ph)VSPSRDSSVPGSPSSIVAK ddPTM_A459_Selumetinib_30min_R2 1 QPLTSPGSVSPSRDSSVPGSPSSIVAK 27 1 Q08495;Q08495-2;E5RGQ0;E5RJ61;A0A087WT94 Q08495 DMTN Dematin 1 QPLT(0.011)S(0.028)PGS(0.443)VS(0.348)PS(0.084)RDS(0.041)S(0.041)VPGS(0.002)PS(0.001)S(0.001)IVAK 55.051 0.005405699999999999 4399000.0 10827.0 8100.9 10151.0 11567.0 10669.0 7248.8 6747.0 7450.2 4760.8 7180.7 True False 10225.278683915045 8722.212981501005 9497.895711573134 9991.554645812039 9328.664837929835 8247.256401945204 7060.748868926866 7471.8788485529985 5713.0930278662345 6973.374533300804 1.4663314920323047 1.2507879707089817 1.3620228866550443 1.4328148585879266 1.3377547403171202 1.1826779649595869 1.0125297064152818 1.0714868121411845 0.8192723624098787 1.0 12.767641254143525 -7.096957538705893 1.4901853921717456 0.9550755470165491 1.3737198526928245 0.8525706236790367 0.07769422882231146 0.14710177813096276 0.6518350123748848 0.04075099886121078 0.027838679636813638 7.99912459219269e-08 7.096957538705893 0.4186443056762754 QPLTSPGSVS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 QPLTSPGSVSPSR 13 0 Q08495;Q08495-2;E5RGQ0;E5RJ61;A0A087WT94 Q08495 DMTN Dematin 1 QPLTSPGSVS(0.878)PS(0.122)R 144.15 0.00068456 4777200.0 7716.6 7229.8 9059.4 10584.0 8953.2 8089.0 10314.0 12677.0 6442.7 8758.9 True False 7287.742263997303 7784.302412528975 8476.528067128917 9142.44094158162 7828.41897337646 9203.186325368988 10793.621436803283 12713.887971209671 7731.420024078681 8506.007798644756 0.8567758737722346 0.9151534535119085 0.9965342458867089 1.074821603506908 0.9203399713110708 1.0819630716580477 1.2689409288483144 1.4946950757834183 0.9089363902664788 1.0 13.054266462346309 -6.999330250702402 4.053464963502804 1.207642017664937 0.9609720413096154 0.28144756730971643 0.15742166669763608 0.24591355890948102 9.372786419655625 0.05909744562257138 0.048657640696785576 1.0015433444808329e-07 6.999330250702402 -0.2466699763553215 QPNSLS(ph)SEEPPTSEDQVGR ddPTM_A459_Selumetinib_30min_R2 1 QPNSLSSEEPPTSEDQVGR 19 0 O15013-7;O15013-4;O15013-5;O15013-6;O15013 O15013-7 ARHGEF10 Rho guanine nucleotide exchange factor 10 1 QPNSLS(0.915)S(0.085)EEPPTSEDQVGR 122.16 0.0011733 0.0 3975.8 4898.4 4694.8 5491.9 4571.5 5238.7 3675.7 4680.6 4040.0 5257.1 True False 3754.8409523884193 5274.091529161519 4392.741679311748 4743.893745944074 3997.187300271465 5960.283372816236 3846.627333261375 4694.219771084958 4848.112887031504 5105.31386341383 0.7354770054974887 1.0330592144309088 0.8604253914321346 0.9292070718590294 0.7829464372242569 1.1674665911393551 0.7534556025688116 0.9194772146576741 0.9496209276719492 1.0 12.31778394219445 -8.720463391581855 0.013683145540120617 1.8815687443825757 5.970390957001187e-06 0.07446642212416821 0.12358793772512552 3273.2840023360923 24.39666708848228 1716.4190771446226 1634.28455529752 1.9034286784271725e-09 8.720463391581855 -1.8815627739916188 QPPGPVPT(ph)PPLPSER ddPTM_A459_Selumetinib_30min_R1 1 QPPGPVPTPPLPSER 15 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QQI0 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 QPPGPVPT(0.964)PPLPS(0.036)ER 91.657 0.033464 14021000.0 572.2 588.81 667.3 678.07 632.31 620.23 591.87 579.34 452.48 556.09 True False 585.5311466926169 519.8718514696571 576.6843252165241 559.6578034503109 575.1176721433976 613.9910493237827 547.2247693827293 563.9740212384662 767.8255121683492 627.4695682752999 0.933162620622451 0.8285212188036589 0.9190634165759352 0.8919282013765536 0.9165666372063273 0.9785192467762778 0.8721136403265958 0.8988069696967753 1.2236856590174403 1.0 9.293401681088431 -8.241511272319597 24.699072797163907 1.1118428179272597 0.9040919261665555 0.6392425426496028 0.06220238696126674 339.92236999719347 421304.515084173 0.03922534868509708 0.01478094109490403 5.73440982419681e-09 8.241511272319597 -0.20775089176070416 QPPGPVPTPPLPS(ph)ER ddPTM_A459_Selumetinib_30min_R1 1 QPPGPVPTPPLPSER 15 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QQI0 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 QPPGPVPT(0.459)PPLPS(0.541)ER 75.445 0.038664 12161000.0 470.34 649.47 727.49 567.34 577.83 658.62 653.72 637.23 374.88 704.53 True False 481.2980068776744 573.4297504695885 628.7008538165276 468.2647192907802 525.5653785241724 651.9948807791133 604.4093740870082 620.3285903852449 636.1439798481052 794.9632882033425 0.6054342559207135 0.7213285933814239 0.7908552044427404 0.5890394263980193 0.6611190558396438 0.8201572204078189 0.7602984729684866 0.780323569138921 0.8002180594852664 1.0 9.63474442734164 -10.376479406248333 0.18608543557751894 1.2306241327903753 0.6216761606825978 0.6924292972087485 0.06276565242842534 11.650040400752811 0.5050109493705642 1.6227545477671634 0.2517625305183232 4.202624555737261e-11 10.376479406248333 -0.6089479721077775 QPPGTQQSHSS(ph)PGEITSSPQGLDNPALLR ddPTM_A459_Selumetinib_30min_R1 2 QPPGTQQSHSSPGEITSSPQGLDNPALLR 29 0 Q5TDH0-2;Q5TDH0;Q5TDH0-3 Q5TDH0-2 DDI2 Protein DDI1 homolog 2 1 QPPGT(0.001)QQS(0.006)HS(0.181)S(0.812)PGEITSSPQGLDNPALLR;QPPGT(0.001)QQS(0.003)HS(0.187)S(0.809)PGEITSSPQGLDNPALLR 115.92 9.7036e-14 43419000.0 1273.79 1521.1799999999998 1561.9699999999998 1457.1 1441.38 1288.2800000000002 1764.09 1728.88 950.67 1208.8000000000002 True False 1303.4668286361216 1343.0795384226044 1349.8630532870573 1202.6448381545385 1311.0074334963074 1275.3210728646511 1631.023271022993 1683.0244862063016 1613.2175558103884 1363.9612547090976 0.9556479878998629 0.9846903889576051 0.9896637815968994 0.8817294728881693 0.9611764476227119 0.9350126834333344 1.195798828883049 1.2339239699043014 1.1827444146530772 1.0 10.413586947768335 -7.260441717911537 24.997789436029265 1.172610475182825 0.9518646482260724 0.6960942131974432 0.06481078684194702 45.262978659553085 1134144.1609160383 0.0248607673097089 0.018126312692648944 5.4898222378623884e-08 7.260441717911537 -0.2207458269567526 QPPGTQQSHSS(ph)PGEITSSPQGLDNPALLR ddPTM_A459_Selumetinib_30min_R2 2 QPPGTQQSHSSPGEITSSPQGLDNPALLR 29 0 Q5TDH0-2;Q5TDH0;Q5TDH0-3 Q5TDH0-2 DDI2 Protein DDI1 homolog 2 1 QPPGTQQSHS(0.251)S(0.749)PGEITSSPQGLDNPALLR;QPPGTQQS(0.001)HS(0.392)S(0.606)PGEITSSPQGLDNPALLR 158.91 5.806699999999999e-19 38691000.0 17931.0 16875.6 26865.0 21717.9 30576.0 31863.0 32735.0 24664.0 23580.4 22908.6 True False 16934.46680348023 18169.904256393536 25136.535148400384 18759.884554532826 26734.769527091827 36251.83902648437 34257.242363171936 24735.768156654984 28297.138891425177 22247.169194309045 0.7611964765302439 0.8167288205387274 1.1298756677245236 0.8432481629766951 1.2017155663081278 1.6295034532194685 1.539847252653391 1.1118613761872471 1.271943349029042 1.0 14.44133415386887 -6.397485128789687 4.35958677937328 1.3393434254189789 0.9016327235607592 0.5086119443778101 0.1953207991279461 0.19452873420438094 6.003935007199403 0.06466195071226483 0.07336964997894746 4.0041917934030403e-07 6.397485128789687 -0.4377107018582197 QPPGVPNGPS(ph)SPTNESAPELPQR ddPTM_A459_Selumetinib_30min_R2 1 QPPGVPNGPSSPTNESAPELPQR 23 0 Q8TF74-2;Q8TF74 Q8TF74-2 WIPF2 WAS/WASL-interacting protein family member 2 1 QPPGVPNGPS(0.449)S(0.449)PT(0.1)NES(0.002)APELPQR 60.747 0.0068615 20284000.0 47543.0 37592.0 50758.0 62799.0 56736.0 46255.0 43198.0 37303.0 42397.0 45817.0 True False 44900.750389708395 40475.18552266861 47492.28554113181 54245.66786568257 49608.31645372459 52626.206388916115 45206.792595213105 37411.54555415592 50877.58467115706 44494.14416313774 1.0091384211162673 0.9096744365790334 1.0673828305810622 1.2191642043229527 1.1149403452246602 1.1827670220144515 1.016016679171588 0.8408195338466681 1.1434669803876762 1.0 15.441327856241823 -10.242882601104295 8.388708257310446 1.0000221757191783 1.0547316591609852 0.021847842346154334 0.11201241002714925 0.0 0.0 0.11653296018521064 0.02826339433585417 5.716331402000569e-11 10.242882601104295 0.05470948344180693 QPPGVPNGPSS(ph)PTNESAPELPQR ddPTM_A459_Selumetinib_30min_R1 2 QPPGVPNGPSSPTNESAPELPQR 23 0 Q8TF74-2;Q8TF74 Q8TF74-2 WIPF2 WAS/WASL-interacting protein family member 2 1 QPPGVPNGPS(0.307)S(0.686)PT(0.008)NESAPELPQR;QPPGVPNGPS(0.193)S(0.767)PT(0.04)NESAPELPQR 129.47 5.4867e-06 35818000.0 3841.04 3467.11 3921.8 4592.9 4092.64 3465.96 4490.0 4429.4 2956.66 3689.2599999999998 True False 3930.528758637206 3061.1791493842893 3389.2411009053862 3790.836234410802 3722.4614346142803 3431.09558923989 4151.3156850802625 4311.917923281081 5017.236074097574 4162.812457435543 0.9442002969930975 0.7353632143375722 0.8141709806915713 0.910643050382843 0.8942179050044121 0.8242253582938446 0.9972382199599827 1.0358184442297438 1.205251527758805 1.0 12.023342848467536 -7.53440964798287 2.0112027019311007 1.0994661302702846 0.8496648706812019 0.6602391020904393 0.07381172024991506 0.19497457766507775 1.5582794236114175 0.04377920486014519 0.022207534357107525 2.9213954734751006e-08 7.53440964798287 -0.24980125958908272 QPPMFS(ph)PLISAR ddPTM_A459_Selumetinib_30min_R1 1 QPPMFSPLISAR 12 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3;F8W719;E7EPJ2 A0A087WVF7 ITSN2 Intersectin-2 1 QPPMFS(0.958)PLIS(0.042)AR 113.37 0.0059856 18954000.0 371.82 551.74 522.38 482.9 400.76 397.14 524.45 358.52 248.13 399.51 True False 380.4826825642238 487.142024303033 451.44366522794496 398.57058015567003 364.5113287599249 393.1451321742693 484.8903142628826 349.01088496291413 421.05848730183095 450.79100005694204 0.844033449017755 1.0806383096412733 1.0014478220969818 0.8841582465162886 0.808603829077957 0.8721228509988195 1.0756432896877561 0.7742188395926904 0.934043685984513 1.0 8.81631490248355 -5.76170590705421 24.999526661147698 0.899040037944845 0.9858997168384912 0.08564350080251704 0.09831332980520326 14.183474643252033 1330610.2943127942 0.026783578797879445 0.04269537417356924 1.7309881426411783e-06 5.76170590705421 0.08685967889364621 QPPMFS(ph)PLISAR ddPTM_A459_Selumetinib_30min_R2 2 QPPMFSPLISAR 12 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3;F8W719;E7EPJ2 A0A087WVF7 ITSN2 Intersectin-2 1 QPPMFS(1)PLISAR;QPPMFS(0.957)PLIS(0.043)AR 128.73 0.0024098 35595000.0 48115.0 37915.0 55199.0 42425.0 36920.0 33638.0 31201.0 37582.0 31659.0 24950.0 True False 45440.96091960581 40822.95858405987 51647.556436127044 36646.64181279291 32281.779531012267 38271.32916463863 32651.908323608604 37691.357397964995 37991.684626368886 24229.628672114857 1.8754295220340058 1.684836327312014 2.1315867913224213 1.5124722837774403 1.3323266306662134 1.5795260291662636 1.3476025062318306 1.5555895597088878 1.5679846001970454 1.0 14.564484674681118 -1.5228787452875416 0.0523406568537814 0.04877329171746203 4.452576930838184 0.5884304856432735 0.1875929378535499 339.4882939227251 1.3433605545458764 25.73429659481355 118.95847781102266 0.02999999999950236 1.5228787452875416 4.403803639120722 QPPPLAPQS(ph)PQGGVMGGSNSNQQQQMR ddPTM_A459_Selumetinib_30min_R2 2 QPPPLAPQSPQGGVMGGSNSNQQQQMR 27 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8;H0YCI3;P46937-4 P46937-6 YAP1 Transcriptional coactivator YAP1 1 QPPPLAPQS(1)PQGGVMGGSNSNQQQQMR;QPPPLAPQS(1)PQGGVMGGSNSNQQQQMR 108.49 1.046e-09 18334600.0 24474.8 17756.9 24373.9 23992.1 27342.8 19826.5 24013.9 21405.5 18479.3 19465.3 True False 23114.58859638716 19118.797132567404 22805.709810295775 20724.334591319006 23907.75301626657 22557.420407952566 25130.593932640128 21467.786461128722 22175.6763547825 18903.286212076833 1.2227814961411223 1.0114007119224004 1.206441544313379 1.096335015976151 1.2647405719854419 1.19330682268045 1.3294299018011388 1.1356642554252547 1.1731122359357296 1.0 14.206349438850118 -4.450423313977912 23.000670158708967 1.1673939261030097 3.792844655413651 0.029231506022160958 0.09816907391168721 2926.1607905220176 952529.9476178943 0.023125586630418957 10132.210162099049 3.544677152789794e-05 4.450423313977912 2.625450729310641 QPPTAAGRPVDAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 QPPTAAGRPVDASPR 15 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 QPPTAAGRPVDAS(1)PR 135.57 0.0019425 10265000.0 701.3 634.06 686.23 740.27 932.81 735.38 584.68 1004.9 548.2 633.73 True False 717.6389255077463 559.8239604335033 593.0437351915709 610.9957410889169 848.4375002009818 727.982744871617 540.5771168714316 978.2467876247703 930.255361056155 715.0754185529424 1.003584946270411 0.7828879946207454 0.8293443178226989 0.8544493702851014 1.1865007217251526 1.0180503006868764 0.7559721713904903 1.3680330245506032 1.3009192274273111 1.0 9.481951599825571 -7.038308738869801 0.7278385579092069 1.1933512848267525 0.86569345050397 0.2699870803548996 0.1745006790578513 0.906959588216157 0.9980715542800249 0.14451130623906502 0.11065162322246452 9.155693827112462e-08 7.038308738869801 -0.3276578343227825 QPPVS(ph)PGTALVGSQK ddPTM_A459_Selumetinib_30min_R2 2 QPPVSPGTALVGSQK 15 0 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 QPPVS(0.997)PGT(0.003)ALVGSQK;QPPVS(0.996)PGT(0.004)ALVGSQK 130.64 0.00077953 13539800.0 31148.0 19887.8 29962.0 34635.0 33263.0 37732.0 45116.0 44336.0 48442.0 25442.0 True False 29416.918855323336 21413.13031064397 28034.277540159026 29917.653251292446 29084.204565007047 42929.2405030069 47213.98339565798 44465.01041978006 58131.753582569334 24707.42335374534 1.1906105478564237 0.8666678837394027 1.1346499850988863 1.2108771045426434 1.177144380804008 1.737503740813967 1.910922993453339 1.7996619794447208 2.352805177224491 1.0 14.592656944704228 -6.763299675411755 3.2493761037891917 1.834933118072444 1.0946009674384631 0.4937366056021212 0.3238905225305897 0.18516345973375598 4.06931819865221 0.11154399883071936 0.10375958250249732 1.7246474260615535e-07 6.763299675411755 -0.7403321506339808 QPS(ph)DASETTGLVQR ddPTM_A459_Selumetinib_30min_R2 2 QPSDASETTGLVQR 14 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 QPS(0.985)DAS(0.013)ET(0.001)TGLVQR;QPS(0.999)DAS(0.001)ETTGLVQR 140.77 0.00055974 18413400.0 24312.2 24999.0 25498.0 27125.0 24589.0 15035.1 17178.2 18439.1 13844.3 29488.0 True False 22961.0252534478 26916.342915545665 23857.48644012331 23430.528206765044 21499.909991550925 17106.048549951203 17977.02033795754 18492.75472824266 16613.546842061944 28636.604820974877 0.8018068272056469 0.9399278679793351 0.8331115573676142 0.818202030346955 0.7507841842969918 0.597349045282836 0.6277636769562247 0.6457732976326036 0.5801507177936595 1.0 14.805572835199847 -6.336146940454399 2.228171385741228 0.6648025500307247 0.8613666544797521 0.27165074284826063 0.11759816314638205 0.33327221328668766 3.247016952862461 0.03790496120630267 0.046174994970133845 4.6116151743634625e-07 6.336146940454399 0.1965641044490274 QPS(ph)EEEIIK ddPTM_A459_Selumetinib_30min_R1 4 QPSEEEIIK 9 0 Q15121-2;Q15121;B1AKZ5 Q15121-2 PEA15 Astrocytic phosphoprotein PEA-15 1 QPS(1)EEEIIK;QPS(1)EEEIIK;QPS(1)EEEIIK;QPS(1)EEEIIK 128.21 0.004377600000000001 325392000.0 16688.7 14930.3 18008.8 23556.1 17991.2 17828.199999999997 13680.8 14395.8 7287.0 12716.5 True False 17077.51423944263 13182.253535091835 15563.303875257518 19442.4693377614 16363.89913660434 17648.864494710433 12648.846241524734 14013.976619851399 12365.506778577523 14348.786644199403 1.1901713129413862 0.9187016200021939 1.084642504009152 1.3549904824615364 1.1404378322970994 1.229990028588592 0.8815272367742758 0.9766663180204611 0.8617806568039232 1.0 13.808641125063174 -7.26711800308305 24.897750739709775 0.9280490710791806 1.1479806273942483 0.49431494271434406 0.11049548601418134 424.76221531862694 1862347.303402276 0.04818319862671644 0.03347869052006113 5.4060741339075994e-08 7.26711800308305 0.21993155631506778 QPS(ph)EEEIIK ddPTM_A459_Selumetinib_30min_R2 4 QPSEEEIIK 9 0 Q15121-2;Q15121;B1AKZ5 Q15121-2 PEA15 Astrocytic phosphoprotein PEA-15 1 QPS(1)EEEIIK;QPS(1)EEEIIK;QPS(1)EEEIIK;QPS(1)EEEIIK 147.33 0.0016507000000000002 353085000.0 218969.0 235954.0 249619.0 221594.0 210113.0 134861.0 145769.0 158248.0 160694.0 186381.0 True False 206799.57958235807 254050.91308830937 233558.78530461816 191412.51492902858 183716.72650594753 153436.87860373195 152547.54733579373 158708.47548063344 192837.29016550488 180999.69625400548 1.1425410310752477 1.4035985603632597 1.2903821947681835 1.0575294814882468 1.0150112420527442 0.8477189839501537 0.842805543285092 0.8768438774499947 1.065401181087548 1.0 17.465627750677847 -5.984047937922557 2.0047713346750053 0.9211448380603069 1.2962189247240263 0.7271948193782143 0.09182111665472865 0.1590382224325521 1.2868117389079188 0.029670177581008234 0.047805394623051896 1.0374138985629928e-06 5.984047937922557 0.37507408666371944 QPS(ph)GSFSTPGSATYVR ddPTM_A459_Selumetinib_30min_R2 1 QPSGSFSTPGSATYVR 16 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 QPS(0.67)GS(0.33)FSTPGSATYVR 201.75 5.5736e-07 19551000.0 7223.2 9500.9 14051.0 16604.0 15192.0 9322.2 10228.0 9223.3 8699.2 11894.0 True False 6821.763460760609 10229.588479791491 13146.973957572076 14342.506556502374 13283.445141796808 10606.248431493983 10703.622266397515 9250.13827600049 10439.283075956553 11550.589315676712 0.5905987369408037 0.885633468580488 1.138208068719811 1.2417121035579033 1.1500231528246119 0.918243055971088 0.9266732608933057 0.8008369117102969 0.9037879185772911 1.0 13.495678839945336 -6.9738242662959715 24.603976564604622 0.8956890389224107 1.0176173715295744 0.059035081418441604 0.17405741510127404 502.33889214458344 472173.2832143035 0.06749871646736227 0.0595265261435496 1.062125250537802e-07 6.9738242662959715 0.12192833260716374 QPS(ph)MSETMPLYTLCK ddPTM_A459_Selumetinib_30min_R1 1 QPSMSETMPLYTLCK 15 0 K7EJD2;A0A0A0MR03;Q9Y5B0 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 QPS(0.998)MS(0.002)ETMPLYTLCK 127.97 0.0010107 8900800.0 574.36 544.78 323.26 395.24 562.96 400.72 685.13 467.64 334.86 457.82 True False 587.7414704899883 480.99690433864924 279.36306754007717 326.2187535736739 512.0403673986606 396.68912062464915 633.4500924986725 455.2366680912008 568.2329627932583 516.5856565444403 1.1377425273894082 0.9311077422399755 0.540787503487419 0.6314901496797758 0.9912012865858796 0.7679057976138816 1.2262247015063583 0.8812414017384513 1.0999782041845656 1.0 9.012863776088777 -7.2374597494170825 24.59075888665329 1.0419645655919016 0.8225132468744542 0.25975227764666375 0.17982477378889622 942.9086292423544 966940.1104332624 0.07221990426742515 0.05591127183402233 5.788156307229569e-08 7.2374597494170825 -0.2194513187174475 QPS(ph)MSETMPLYTLCK ddPTM_A459_Selumetinib_30min_R2 1 QPSMSETMPLYTLCK 15 0 K7EJD2;A0A0A0MR03;Q9Y5B0 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 QPS(0.677)MS(0.313)ET(0.009)MPLYTLCK 79.317 0.031310000000000004 5846900.0 11262.0 9771.1 10272.0 13024.0 11375.0 10987.0 13767.0 10310.0 13525.0 13585.0 True False 10636.103125358008 10520.511950961569 9611.110703307972 11250.108732346845 9945.97080620976 12500.359519944246 14407.192778792982 10340.00039308762 16230.377920074518 13192.765751931078 0.8062072294280794 0.7974455204301372 0.7285137084997628 0.8527483125136306 0.753895808750635 0.9475162187363569 1.0920524967771934 0.7837629036636319 1.2302483213346536 1.0 13.68745942467847 -6.886157909907053 4.453229424541979 1.0099582246990824 0.7890586909098193 0.5229937582192483 0.10788671478920578 0.1783963899222001 6.120577744558121 0.03650381331028553 0.03209873871434304 1.2996969210116177e-07 6.886157909907053 -0.22089953378926308 QPS(ph)PFVDDCK ddPTM_A459_Selumetinib_30min_R2 1 QPSPFVDDCK 10 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 QPS(1)PFVDDCK 107.46 0.011274 5618000.0 32236.0 27416.0 39460.0 37441.0 39397.0 29466.0 34199.0 29571.0 23136.0 30891.0 True False 30444.4521709324 29518.719043665722 36921.186560799506 32341.471210672473 34447.596646351296 33524.67403428393 35789.3212640329 29657.0467142574 27763.846473851685 29999.096565543092 1.0148456339148841 0.9839869337122261 1.2307432818895991 1.0780815062217517 1.1482878016372582 1.1175227880959027 1.1930133024452627 0.9885979949250016 0.9254894197627668 1.0 14.872631433602724 -7.902821532823065 6.939364943391269 0.9610418691901158 1.1096255408454947 0.43855128990667747 0.07196213262637474 0.20130699824824613 12.170103604275369 0.04097200550617981 0.019491939214459488 1.2507729120680334e-08 7.902821532823065 0.1485836716553789 QPS(ph)PIVPALQNK ddPTM_A459_Selumetinib_30min_R2 2 QPSPIVPALQNK 12 0 Q1MSJ5;Q1MSJ5-1;Q1MSJ5-2 Q1MSJ5 CSPP1 Centrosome and spindle pole-associated protein 1 1 QPS(1)PIVPALQNK;QPS(1)PIVPALQNK 111.72 0.006979600000000001 4082600.0 32011.0 31128.0 33899.0 35246.0 39223.0 23561.0 30303.0 27482.0 24562.0 29115.0 True False 30231.95677018605 33515.41750770451 31717.97524644051 30445.433997258653 34295.45608193103 26806.313884536867 31712.149544255342 27561.96807010998 29475.086319620754 28274.374300145235 1.0692352180550555 1.1853637202338498 1.1217922953745996 1.0767854196901632 1.2129519018836383 0.9480780582436857 1.1215862536025227 0.9748038197955243 1.0424664399901273 1.0 14.787207477891315 -6.7634479487506844 24.999999921083774 1.0223246188874198 1.1323515015911676 0.48833663155604934 0.05917536674131781 47.39527716578641 589906.5166642009 0.01914038699437795 0.01773030605291822 1.7240587112720388e-07 6.7634479487506844 0.11002688270374783 QPS(ph)PSHDGSLS(ph)PLQDR ddPTM_A459_Selumetinib_30min_R1 2 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 2 QPS(0.86)PS(0.14)HDGS(0.235)LS(0.765)PLQDR;QPS(0.969)PS(0.031)HDGS(0.17)LS(0.83)PLQDR 149.72 0.0045661 105953000.0 3758.7 4135.7 4468.9 4472.3 4912.2 3958.0 4573.0 3869.1 2442.8 3529.4 True False 3846.270396842958 3651.4903213652315 3862.0479259105714 3691.296760468429 4467.892377319346 3918.1861135764625 4228.05492825658 3766.4788993919756 4145.253184947054 3982.4328692672816 0.9658092234334696 0.9168994032627751 0.9697710049839812 0.9268949111369659 1.1219002363601382 0.9838674604695496 1.0616763840226362 0.9457733558946245 1.0408846353534968 1.0 11.95943432751965 -6.153977252940424 20.740886601809596 1.022876869536863 0.9446242783318695 0.4177550147771776 0.046681134700014 7.775035644971982 1491.5257036216374 0.013082609503849655 0.016889643579182167 7.01492039534584e-07 6.153977252940424 -0.07825259120499362 QPS(ph)PSHDGSLS(ph)PLQDR ddPTM_A459_Selumetinib_30min_R2 4 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 2 QPS(0.984)PS(0.016)HDGS(0.02)LS(0.98)PLQDR;QPS(0.982)PS(0.018)HDGS(0.095)LS(0.905)PLQDR;QPS(0.827)PS(0.173)HDGS(0.07)LS(0.93)PLQDR;QPS(0.753)PS(0.246)HDGS(0.036)LS(0.965)PLQDR 152.86 0.002909 259501000.0 92410.0 76884.0 99526.0 113080.0 109711.0 77186.0 73978.0 79996.0 69173.0 87858.0 True False 87274.22214654012 82780.75557897554 93122.60551571538 97678.30892611961 95928.12335121584 87817.67087525419 77418.12358462598 80228.77511594932 83009.53285510668 85321.31125750185 1.0228888991537453 0.9702236681424311 1.0914342986908514 1.1448289704705081 1.1243160933345524 1.0292583362932417 0.9073714696082923 0.9403134332267453 0.9729050296072201 1.0 16.380618517405132 -7.058537088061771 5.471771524799545 0.9513060844622276 1.071158697275754 0.5317170807796359 0.05111336192524736 0.18650734940387173 11.731225957003062 0.022150569854077044 0.017342976896076258 8.73902359524731e-08 7.058537088061771 0.11985261281352644 QPS(ph)PSHDGSLSPLQDR ddPTM_A459_Selumetinib_30min_R1 2 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 QPS(0.983)PS(0.017)HDGSLSPLQDR;QPS(0.844)PS(0.156)HDGSLSPLQDR 212.35 3.0004e-08 195350000.0 3318.4 3090.8 3052.7 3310.2 3815.1000000000004 3016.7 3210.9 2781.4 1676.08 2381.15 True False 3395.712263517618 2728.927699126064 2638.160107280808 2732.135710149719 3470.0248786106145 2986.3547369444477 2968.69922788958 2707.6282367395115 2844.1853439602332 2686.793796865128 1.2638529489980344 1.0156818518451607 0.9818989869482859 1.0168758441148311 1.2915114225212732 1.1114938334414939 1.1049226149596485 1.0077543873663444 1.058579689769548 1.0 11.391669887868225 -7.752753387695683 23.59073382113377 1.0248752805745143 1.1067759667560517 0.1536089728940343 0.0963578667245094 204.08020566450395 554280.2909759709 0.04874862898593783 0.027532195987769868 1.7670409426553067e-08 7.752753387695683 0.08190068618153745 QPS(ph)PSHDGSLSPLQDR ddPTM_A459_Selumetinib_30min_R2 2 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 QPS(0.949)PS(0.051)HDGSLSPLQDR;QPS(0.531)PS(0.469)HDGSLSPLQDR 180.02 1.0357e-06 323500000.0 77256.0 75283.0 68403.0 84418.0 83437.0 80179.0 60577.0 59506.0 69206.0 74420.0 True False 72962.42080027156 81056.96402700219 64002.02545155528 72920.12277082745 72954.89812375595 91222.92945750523 63393.95053104829 59679.15260825137 83049.13377720372 72271.30123361883 1.009562849358678 1.1215650284887426 0.8855800900092707 1.0089775820572442 1.0094587599568379 1.2622289608792954 0.8771663087416364 0.8257655748488184 1.14913018528261 1.0 16.14113524958227 QPS(ph)PSPSPTER ddPTM_A459_Selumetinib_30min_R2 1 QPSPSPSPTER 11 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BT57;P29590-10;P29590-14 P29590-2 PML Protein PML 1 QPS(0.5)PS(0.5)PSPTER 109.6 0.0093033 25457000.0 5686.1 9454.9 9635.6 6476.3 9540.0 2314.1 8269.9 8583.7 8137.0 6729.3 True False 5370.0893252617825 10180.060427704815 9015.655986448042 5594.216767759359 8341.499911317902 2632.8462696917254 8654.46673649597 8608.677145891974 9764.62736677607 6535.007624178857 0.821741860773506 1.5577733054265517 1.3795937977319324 0.8560382924514627 1.2764330802699002 0.4028834273965442 1.3243238928253627 1.3173170776481962 1.4942029035510151 1.0 12.67397320382872 -10.369446509618337 12.982397431370098 0.9993392742784811 1.1589789883896815 0.019162362343241646 0.34109692255145757 0.0 0.0 0.3324086234583458 0.08062093325793698 4.2712352336343665e-11 10.369446509618337 0.15963971411120037 QPS(ph)SPSHNTNLR ddPTM_A459_Selumetinib_30min_R1 1 QPSSPSHNTNLR 12 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 QPS(0.463)S(0.463)PS(0.073)HNT(0.001)NLR 145.83 0.00067258 11992000.0 1294.4 835.22 903.41 1093.6 1348.2 1066.4 1183.6 1015.7 293.12 659.47 True False 1324.5570015360427 737.4320541167564 780.7318840759174 902.6232894144559 1226.2555480440421 1055.6729842137297 1094.3200990781736 988.7603365414261 497.4032313622401 744.1193982817742 1.78003288799424 0.9910130764223329 1.049202434284987 1.2130086804599889 1.6479284787838555 1.4186876281566578 1.4706243401328312 1.328765704569113 0.6684454571548334 1.0 9.539390318485161 -9.883661023411038 6.54288345136584 1.0000000000341291 1.288892835504634 0.07089861840546108 0.30959412318612756 68519967.3414266 0.0 0.300660380805036 0.07516509520125902 1.3071907817944762e-10 9.883661023411038 0.2888928354705049 QPS(ph)SPSHNTNLR ddPTM_A459_Selumetinib_30min_R2 1 QPSSPSHNTNLR 12 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 QPS(0.99)S(0.009)PS(0.001)HNTNLR 100.18 0.0090506 6689200.0 7453.5 5522.7 7715.5 15017.0 14550.0 7675.6 8317.9 8559.6 11114.0 12318.0 True False 7039.264308724554 5946.273331720627 7219.0931300012335 12971.658694230078 12722.098921349623 8732.844227840545 8704.698831606165 8584.507018881939 13337.110551105967 11962.347333992418 0.5884517571832792 0.4970824843735803 0.6034846613663633 1.0843740222597937 1.0635119150234236 0.7300276429045945 0.7276748106845835 0.7176272999938775 1.1149242016411776 1.0 13.546212892398891 -5.632764382575976 6.783752598631939 0.8972935680510432 0.5451706683803414 0.5536615212847669 0.14635647303512017 0.1761820547886926 9.827901774743035 0.04279369520286355 0.0745713062977696 2.3293546577632523e-06 5.632764382575976 -0.35212289967070176 QPS(ph)SPYEDKDK ddPTM_A459_Selumetinib_30min_R2 1 QPSSPYEDKDK 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QPS(0.499)S(0.499)PY(0.003)EDKDK 69.815 0.037418 3797900.0 26640.0 17651.0 21783.0 21042.0 21719.0 17097.0 26273.0 23454.0 16811.0 19468.0 True False 25159.455448369514 19004.774943089575 20381.505495537152 18176.04330052537 18990.465049676455 19451.956558886573 27494.746558961862 23522.247256981274 20173.669738585802 18905.908256061408 1.3307721114272921 1.0052294068969931 1.0780495292524577 0.9613948747846041 1.004472506291145 1.0288824157733918 1.4542938739876088 1.2441744103692995 1.0670563648862486 1.0 14.206549538847636 QPS(ph)SPYEDKDKDK ddPTM_A459_Selumetinib_30min_R2 1 QPSSPYEDKDKDK 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QPS(0.499)S(0.499)PY(0.001)EDKDKDK 80.719 0.041265 24403000.0 104840.0 76613.0 89115.0 75198.0 69435.0 64728.0 117340.0 94254.0 53588.0 63403.0 True False 99013.41250777253 82488.970750378 83381.43792107567 64955.90267621444 60711.95454322408 73643.69445771846 122796.54250479891 94528.26353541034 64307.0973738228 61572.39064922233 1.6080813407400658 1.3397071297802505 1.3542017297346696 1.0549517728858047 0.9860256180257779 1.1960505947749585 1.9943442378966627 1.5352378320656328 1.0444144964287658 1.0 15.909995964195037 -8.346997519456142 6.979334457920964 1.011285021848716 1.3706898835721966 0.21643002134934863 0.2743190368302206 0.5087459075134875 34.99631194134275 0.2920100272967258 0.07574640411126347 4.497824238917192e-09 8.346997519456142 0.35940486172348063 QPS(ph)VETLDSPTGSHVEWCK ddPTM_A459_Selumetinib_30min_R2 2 QPSVETLDSPTGSHVEWCK 19 0 F8WA39;Q13613;E9PPP8;Q8NEC6;Q13613-2 F8WA39 MTMR1 Myotubularin-related protein 1 1 QPS(0.707)VET(0.283)LDS(0.009)PTGSHVEWCK;QPS(0.559)VET(0.14)LDS(0.278)PT(0.023)GSHVEWCK 123.36 0.00027353 11659100.0 64649.0 51437.0 71957.0 82781.0 82007.0 58883.0 64481.0 60818.0 63744.0 68705.0 True False 61056.067390451935 55382.05250397702 67327.36496085797 71506.08499480993 71704.54750811808 66993.59876334544 67479.49426667756 60994.970311038116 76494.58115617244 66721.3081329721 0.9150909821607569 0.830050459946071 1.00908340745775 1.0717128754775314 1.0746873752117485 1.0040810145663013 1.011363478248874 0.914175276502048 1.1464790379067915 1.0 16.025859953980273 -5.335749379041353 5.899367023380071 1.0284716938442944 0.8731844269764947 0.5182983238158565 0.060429737065258234 0.15753342993495031 9.618762084720732 0.01556674937309578 0.033268048968569545 4.615838667275282e-06 5.335749379041353 -0.1552872668677997 QPSGS(ph)FSTPGSATYVR ddPTM_A459_Selumetinib_30min_R1 2 QPSGSFSTPGSATYVR 16 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 QPS(0.026)GS(0.925)FS(0.038)T(0.012)PGSATYVR;QPS(0.003)GS(0.994)FS(0.003)TPGSATYVR 243.37 8.948e-22 82731000.0 826.5999999999999 893.31 1006.1300000000001 811.51 927.3499999999999 825.28 868.48 900.79 403.26 673.9300000000001 True False 845.8581717163873 788.720849911448 869.5030722764892 669.7950124293393 843.4713562369401 816.9784324942858 802.9698543827406 876.8981230217098 684.3027670549159 760.435480134102 1.1123339110468926 1.0371962783382462 1.1434278055031746 0.8808045257320471 1.1091951628666705 1.0743560155165466 1.0559342315815374 1.1531525631432527 0.8998827447323208 1.0 9.570682036094919 -8.272656199712989 24.996077702615818 0.9499413713092693 1.0666705179719864 0.2864925639373598 0.0760692387242666 1066.6776870669387 2377009.1612067777 0.06802112977738518 0.018156166281125 5.3375726623788e-09 8.272656199712989 0.11672914666271716 QPSGS(ph)FSTPGSATYVR ddPTM_A459_Selumetinib_30min_R2 3 QPSGSFSTPGSATYVR 16 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 QPS(0.126)GS(0.807)FS(0.033)T(0.033)PGS(0.001)ATYVR;QPS(0.014)GS(0.981)FS(0.002)T(0.003)PGSATYVR;QPS(0.007)GS(0.828)FS(0.137)T(0.028)PGSATYVR 215.64 2.4439e-09 32790100.0 32675.9 33057.9 32321.2 39088.0 34317.2 33084.4 30683.4 26292.2 24380.9 35467.1 True False 30859.90428999165 35593.33463209794 30241.68918066179 33764.146969438996 30005.96653633948 37641.47578971907 32110.23889800364 26368.705949091982 29257.761259263945 34443.072668407396 0.8959683878116259 1.0333960321938875 0.8780194923898503 0.9802884688742901 0.8711756591874042 1.0928605630543928 0.9322698705524166 0.7655735654873337 0.8494527053650579 1.0 15.071926230929302 -7.541100024469842 24.529830362935506 0.8542921518272586 0.960130665728802 0.1661433755783005 0.08443257505380132 272.20196594696836 366437.94593446975 0.03753345036701255 0.021675284244687575 2.8767357834520428e-08 7.541100024469842 0.10583851390154342 QPSPS(ph)HDGS(ph)LSPLQDR ddPTM_A459_Selumetinib_30min_R2 1 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 2 QPS(0.373)PS(0.642)HDGS(0.982)LS(0.003)PLQDR 108.12 0.012774 140200000.0 23996.0 22680.0 27700.0 31215.0 26826.0 24091.0 20464.0 21048.0 20977.0 24121.0 True False 22662.3983835989 24419.48307230591 25917.81215747963 26963.46315112151 23455.878052517175 27409.3165736759 21415.616548646725 21109.246195316035 25172.98614635145 23424.564056115538 0.9674629730273397 1.042473320477041 1.1064373319986365 1.1510764122025168 1.001336801672237 1.1701099968398365 0.9142375711814227 0.901158550688373 1.074640539138633 1.0 14.51573457834394 -7.277242661199399 24.994462695573432 0.96427237873505 1.0735461127675903 0.3088223929415278 0.07334517048095618 982.5755015044507 1554034.6153539696 0.030516898224969353 0.02064298157356028 5.281500664905136e-08 7.277242661199399 0.10927373403254026 QPSPS(ph)HDGSLSPLQDR ddPTM_A459_Selumetinib_30min_R1 2 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 QPS(0.234)PS(0.765)HDGS(0.001)LSPLQDR;QPS(0.244)PS(0.756)HDGSLSPLQDR 161.2 4.8475e-05 187102000.0 2535.27 2778.16 2783.2799999999997 3289.3399999999997 3491.9 2347.24 3072.05 2687.87 1516.42 2290.76 True False 2594.3368582233334 2452.891735668454 2405.3258634626795 2714.9185175590214 3176.0582615450176 2323.628896723402 2840.3227951783565 2616.5789561677684 2573.2539850652593 2584.801359891969 1.003689064265953 0.9489672102969539 0.9305650719570999 1.0503393257548004 1.2287436515731949 0.8989584007416792 1.0988553469722204 1.0122940187083187 0.9955325871434886 1.0 11.335837699395675 -5.7717131983058465 24.868640696062656 1.045542572300779 0.9598631259083212 0.1649644861861259 0.08154337570107079 317.5424962139768 768638.7851473031 0.022768838959308764 0.03420129350185413 1.6915576426837086e-06 5.7717131983058465 -0.08567944639245773 QPSPS(ph)HDGSLSPLQDR ddPTM_A459_Selumetinib_30min_R2 3 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 QPS(0.292)PS(0.694)HDGS(0.013)LSPLQDR;QPS(0.163)PS(0.835)HDGS(0.002)LSPLQDR;QPS(0.104)PS(0.76)HDGS(0.12)LS(0.016)PLQDR 164.2 2.6313e-05 29033700.0 18800.5 14716.8 25050.9 32763.5 30077.3 20888.4 19599.4 20748.2 19589.5 26220.2 True False 17755.643474364533 15845.531238029613 23439.15236735766 28301.054779810012 26298.72067952638 23765.587493984116 20510.810935474325 20808.573826950575 23507.94737636228 25463.15469773891 0.6973072930331451 0.6222925409724142 0.9205125070162269 1.1114512367284601 1.0328147078280785 0.9333324081832823 0.8055094185676708 0.8172032913423074 0.9232142542985748 1.0 14.636123549175112 -5.2833850022077655 8.578227831038532 0.9406552397407637 0.6596929113418907 0.6211406671772366 0.08846140915913069 0.17601979978483365 64.27030278016211 0.026632009732774044 0.0575381964164186 5.2073287655269216e-06 5.2833850022077655 -0.28096232839887303 QPSPS(ph)PSPTER ddPTM_A459_Selumetinib_30min_R1 2 QPSPSPSPTER 11 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BT57;P29590-10;P29590-14 P29590-2 PML Protein PML 1 QPS(0.007)PS(0.67)PS(0.321)PT(0.002)ER;QPS(0.384)PS(0.605)PS(0.005)PT(0.005)ER 130.19 0.0024421 22366800.0 1430.52 1785.1299999999999 1493.21 1454.0300000000002 1627.95 1272.38 1948.6200000000001 1441.8400000000001 976.5999999999999 1667.23 True False 1463.8483326926284 1576.1261497155785 1290.4402836154147 1200.110956023502 1480.7022099379167 1259.5810124286054 1801.6340245570373 1403.5977194436248 1657.2188719581186 1881.2352106954415 0.7781314767925716 0.8378145065299557 0.6859537160897462 0.6379377491982269 0.7870904188480192 0.669549987831119 0.9576867444932747 0.7461043209608823 0.8809206113814391 1.0 10.877464524851922 -7.256822345308584 24.96156642661746 0.8750199461558438 0.7335559073059552 0.46974237869631297 0.08386669266335105 400.52958710542623 2165431.6146442806 0.03288135793615637 0.02459260722639022 5.535765117061114e-08 7.256822345308584 -0.14146403884988856 QPSPS(ph)PSPTER ddPTM_A459_Selumetinib_30min_R2 3 QPSPSPSPTER 11 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BT57;P29590-10;P29590-14 P29590-2 PML Protein PML 1 QPS(0.07)PS(0.706)PS(0.222)PT(0.002)ER;QPS(0.304)PS(0.612)PS(0.079)PT(0.005)ER;QPS(0.03)PS(0.943)PS(0.018)PT(0.008)ER 130.19 0.0034531 30818400.0 57820.0 51101.0 63856.2 65238.0 73982.0 62144.0 58443.0 61717.0 64421.1 51668.5 True False 54606.59587179898 55020.2823843873 59747.76161337373 56352.471858172874 64687.719752528326 70703.77191293494 61160.715302607554 61896.58625220061 77307.12007592706 50176.69615411486 1.088285998426001 1.0965305929149984 1.1907472231703315 1.1230805568602897 1.2891984668309704 1.4090958020785653 1.2189067832357057 1.233572375153772 1.5406976943735522 1.0 15.614729860280747 -6.270460119569738 7.304807938883407 1.29706617450664 1.1271480809982752 0.24683006842337452 0.1329858403887687 0.1907250437837571 70.85958389232553 0.038862856724007244 0.046209417808561255 5.364631315601583e-07 6.270460119569738 -0.16991809350836484 QPSPSHDGSLS(ph)PLQDR ddPTM_A459_Selumetinib_30min_R2 1 QPSPSHDGSLSPLQDR 16 0 Q96A00-2;Q96A00;A0A0B4J2A3 Q96A00-2 PPP1R14A Protein phosphatase 1 regulatory subunit 14A 1 QPS(0.015)PS(0.052)HDGS(0.324)LS(0.609)PLQDR 91.065 0.011874 9179300.0 7278.9 2061.1 7407.6 13508.0 18841.0 8732.7 8373.6 7030.1 8697.5 10195.0 True False 6874.367877745375 2219.1797425189447 6931.00308078506 11668.187097400272 16474.025139322905 9935.550157442174 8762.988991973622 7050.5564271042895 10437.243028454577 9900.64386020886 0.6943354366450624 0.22414499237144864 0.7000557921935843 1.178528110105571 1.6639347270668692 1.0035256593132902 0.8850928399911924 0.7121311024468618 1.0541984113177056 1.0 13.273306634473093 -5.5785636456244125 4.500636896455145 1.070619513236423 0.45669398490341945 0.49183692181807703 0.2549290611724638 0.17561472844944964 7.362881308034372 0.07716167181713038 0.14166016021308603 2.6389815526886294e-06 5.5785636456244125 -0.6139255283330034 QPSS(ph)PGPTPR ddPTM_A459_Selumetinib_30min_R1 1 QPSSPGPTPR 10 0 Q13424-2;Q13424 Q13424-2 SNTA1 Alpha-1-syntrophin 1 QPS(0.197)S(0.801)PGPT(0.002)PR 90.697 0.03236 0.0 1223.3 1166.6 2003.0 1679.3 1560.6 1254.3 1460.9 1402.5 847.77 1180.5 True False 1251.8005098725596 1030.0139296623734 1731.0036016914391 1386.041779365121 1419.444005546308 1241.6828808132793 1350.7031368226617 1365.3011440379541 1438.6037713290345 1332.0286740437546 0.9397699420931838 0.7732670848109231 1.2995242785851464 1.0405495064587418 1.065625713024014 0.9321742879932121 1.014019565151113 1.0249787941074808 1.0800096119265516 1.0 10.379409423719512 -5.218653814315859 24.999997472638672 1.0517142737503533 0.8565184891957911 0.40182700937466465 0.09771907196668797 482.2072858542123 281756.5837888477 0.024692137956949203 0.06532813946626781 6.044302420396575e-06 5.218653814315859 -0.1951957845545622 QPSS(ph)PGPTPR ddPTM_A459_Selumetinib_30min_R2 1 QPSSPGPTPR 10 0 Q13424-2;Q13424 Q13424-2 SNTA1 Alpha-1-syntrophin 1 QPS(0.372)S(0.627)PGPT(0.001)PR 107.93 0.010992 19297000.0 46961.0 42333.0 50677.0 53073.0 61230.0 34152.0 42655.0 44149.0 41038.0 48156.0 True False 44351.09561977781 45579.804977950895 47416.4969929457 45844.36584396834 53537.73999685484 38856.1279990112 44638.542019279026 44277.46628073961 49246.74669752448 46765.61115568586 0.9483698496343826 0.9746436291875383 1.0139180440750148 0.9803007960560886 1.1448100147483182 0.8308696719402756 0.9545163832174527 0.9467954162586896 1.0530547015322596 1.0 15.513160421070284 -6.7701402160994935 24.999967102959893 0.9535638224659844 1.0086105340657285 0.12794705486750602 0.07163655569022366 430.52711139915544 1237018.2538988488 0.02508809026771455 0.022469129583975386 1.6976954468658522e-07 6.7701402160994935 0.05504671159974417 QPSS(ph)PSHNTNLR ddPTM_A459_Selumetinib_30min_R1 1 QPSSPSHNTNLR 12 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 QPS(0.023)S(0.708)PS(0.263)HNT(0.007)NLR 152.0 0.00050739 7910300.0 766.13 808.21 819.84 895.26 1404.9 842.23 1286.0 773.13 235.58 617.7 True False 783.9793383705254 713.5843974733642 708.5102310587664 738.9196471115457 1277.8270430552407 833.7579308836553 1188.99598463546 752.6240809198312 399.76205391756446 696.9878119075198 1.1248106853187672 1.023811873439254 1.016531736931973 1.0601615042439072 1.8333563675354339 1.1962302878752245 1.7059064223539429 1.0798238764893833 0.5735567352655617 1.0 9.444989617956917 -8.005948523000864 24.97986943269198 0.8000822495530671 1.2785088856273232 0.32707423633335797 0.28166937639481665 301.4322496265017 1265809.3813392965 0.1685852396244224 0.07674621838853529 9.863963964357328e-09 8.005948523000864 0.4784266360742562 QPSS(ph)PSHNTNLR ddPTM_A459_Selumetinib_30min_R2 2 QPSSPSHNTNLR 12 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 QPS(0.143)S(0.857)PSHNTNLR;QPS(0.132)S(0.868)PSHNTNLR 108.36 0.0053543 21776700.0 17075.1 14523.5 24765.0 34337.0 42329.0 25251.0 23455.1 24032.1 25179.0 31366.0 True False 16126.134299041067 15637.405749587066 23171.646862093254 29660.24136537111 37011.25259393873 28729.096044244303 24545.80862539894 24102.029432271658 30215.50356004113 30460.38208134488 0.5294133952744255 0.5133686671371079 0.7607142550022203 0.9737317570791796 1.21506199413716 0.9431626946609811 0.8058273386016305 0.7912582766659607 0.9919607534583841 1.0 14.894646418006444 -5.473031625837004 2.8070913226107055 0.9540106684604941 0.5193342528190796 0.7146574877529737 0.11068145750077547 0.16170699122237628 2.4980524743043304 0.03508591877630103 0.08156370957335442 3.3648706509786875e-06 5.473031625837004 -0.43467641564141446 QPSS(ph)PYEDKDK ddPTM_A459_Selumetinib_30min_R1 4 QPSSPYEDKDK 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QPS(0.346)S(0.653)PY(0.001)EDKDK;QPS(0.08)S(0.92)PYEDKDK;QPS(0.078)S(0.922)PYEDKDK;QPS(0.02)S(0.98)PYEDKDK 206.46 8.3055e-05 188789000.0 20298.699999999997 27595.1 13123.3 13495.5 13964.7 18133.9 20900.6 21420.199999999997 11782.9 24691.199999999997 True False 20771.62021560542 24364.252863386067 11341.227941126936 11138.764266910013 12701.59535066803 17951.48943026384 19324.050914830408 20852.066713384505 19994.72071103352 27860.556032654935 0.7455565564183041 0.8745070570317799 0.40707112693063463 0.3998040905520492 0.45589884623195187 0.6443334946087641 0.6935988963099294 0.7484440256305048 0.7176712728776127 1.0 14.76593643065261 -8.526486797974101 0.7623016116915534 0.9913399031706301 0.5832788701696601 0.41191842889481145 0.14429150022511328 0.8058244098799665 1.0555047057888693 0.15857405872526595 0.05987610066185726 2.975179699363265e-09 8.526486797974101 -0.4080610330009701 QPSS(ph)PYEDKDK ddPTM_A459_Selumetinib_30min_R2 4 QPSSPYEDKDK 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QPS(0.21)S(0.769)PY(0.021)EDKDK;QPS(0.015)S(0.985)PYEDKDK;QPS(0.063)S(0.937)PYEDKDK;QPS(0.063)S(0.937)PYEDKDK 224.43 1.7894000000000002e-05 333473000.0 541174.0 383342.0 398849.0 440919.0 372928.0 352703.0 593340.0 539187.0 392812.0 351934.0 True False 511097.7155711683 412743.0987611938 373187.4895739562 380865.07157230045 326077.4506213793 401284.63673094497 620931.4856809048 540755.9449027864 471385.3760843124 341772.75098565326 1.495431435353437 1.207653616535742 1.0919170369718025 1.1143810338124007 0.9540767942470264 1.1741270641783548 1.8167963475443072 1.5822090653607606 1.3792362753463043 1.0 18.382677852185303 -7.052507488641691 24.01802560591095 1.4934188509185298 1.1566267440827134 0.23762638371910239 0.23094315739173757 259.6930549629948 118787.9745804605 0.08731547129919394 0.06763514120122509 8.861199439535769e-08 7.052507488641691 -0.3367921068358164 QPSS(ph)PYEDKDKDK ddPTM_A459_Selumetinib_30min_R2 1 QPSSPYEDKDKDK 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QPS(0.228)S(0.771)PY(0.001)EDKDKDK 101.04 0.011802 27644000.0 134610.0 100760.0 101590.0 103750.0 74844.0 67765.0 123550.0 108860.0 66071.0 76123.0 True False 127128.91508652469 108487.96800553554 95053.81000282874 89619.07102126715 65441.42760615054 77099.01364057716 129295.31980968059 109176.76457725694 79287.0461779847 73925.13119869318 1.7196982003972692 1.467538389806109 1.2858118539870655 1.2122950553904652 0.8852392487510037 1.0429337410758641 1.7490035893499531 1.476855878467307 1.072531693787326 1.0 16.173777278321644 -4.942201084771113 1.828961395247328 1.2296564624545137 1.7898549959108527 0.3165958222198385 0.23731216607811018 0.853896935252616 3.827042459194786 0.07206578443539012 0.7465918717493717 1.1423492876980554e-05 4.942201084771113 0.5601985334563391 QPSSS(ph)PSSIIR ddPTM_A459_Selumetinib_30min_R2 1 QPSSSPSSIIR 11 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 QPS(0.002)S(0.303)S(0.615)PS(0.065)S(0.015)IIR 91.307 0.026602 16735000.0 22515.0 17982.0 21056.0 25904.0 23589.0 18480.0 19144.0 21049.0 17566.0 19088.0 True False 21263.706434686166 19361.161578756833 19701.2798840394 22375.830513107554 20625.53893166434 21025.452255262564 20034.233933116353 21110.24910515047 21079.69083504837 18536.879843419967 1.147102781821944 1.0444671240413452 1.062815320078409 1.2070979961091077 1.1126758713379579 1.1342498000129166 1.0807770294863244 1.1388242942430233 1.1371757821762558 1.0 14.17811080726436 -12.01486529331923 1.894314558236929 2.134220437074728e-05 1.116954884126841 0.38948407530546236 0.044422599112321444 606249.9683742623 32912.13289585266 2617899.407448177 0.012115555949340964 9.663505689395184e-13 12.01486529331923 1.1169335419224704 QPSVET(ph)LDSPTGSHVEWCK ddPTM_A459_Selumetinib_30min_R1 1 QPSVETLDSPTGSHVEWCK 19 0 F8WA39;Q13613;E9PPP8;Q8NEC6;Q13613-2 F8WA39 MTMR1 Myotubularin-related protein 1 1 QPS(0.074)VET(0.912)LDS(0.013)PTGSHVEWCK 126.86 0.00048831 6885600.0 1063.7 1032.0 1273.4 1183.3 1042.3 1059.9 1300.3 1064.6 634.54 1058.7 True False 1088.482140400099 911.172960236216 1100.4792742855109 976.6588682919946 948.0241490330116 1049.238368312202 1202.2173241224639 1036.3633496918403 1076.768035032055 1194.5944576112852 0.9111729369451717 0.7627466831364682 0.9212157877293627 0.8175652097406552 0.793594966888331 0.8783218117471115 1.0063811333315755 0.8675440799919294 0.9013670105126419 1.0 10.222305218104387 -7.006487114024854 24.521753738110203 0.9341516983706084 0.8396165521605011 0.3946902885418385 0.05946131256008807 250.06438891251588 945263.9664708454 0.020647041053645895 0.017568297617564566 9.851738735178552e-08 7.006487114024854 -0.09453514621010728 QPT(ph)PPSEAAASK ddPTM_A459_Selumetinib_30min_R2 3 QPTPPSEAAASK 12 0 Q86UP2-2;Q86UP2-3;Q86UP2-4;Q86UP2 Q86UP2-2 KTN1 Kinectin 1 QPT(0.86)PPS(0.138)EAAAS(0.002)K;QPT(0.991)PPS(0.009)EAAASK;QPT(0.695)PPS(0.279)EAAAS(0.025)K 105.95 0.021296 43172700.0 108085.0 42591.0 94065.0 99902.0 53949.0 50196.0 147341.0 88929.0 83403.0 69217.0 True False 102078.06839853672 45857.592748350115 88012.9603102281 86295.17525943772 47171.444309820676 57110.04336608003 154192.6484506527 89187.76866701148 100085.9304745269 67218.5253626363 1.5186002347989211 0.6822165839097721 1.3093557145951684 1.2838004819933948 0.7017625580944553 0.8496176174347451 2.293901087814719 1.3268331637127355 1.488963495324759 1.0 16.036571272755502 QPTAEGSGSDAHSVESLTAQNLSLHSGT(ph)ATPPLTSR ddPTM_A459_Selumetinib_30min_R2 1 QPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSR 36 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 QPTAEGSGSDAHS(0.003)VES(0.004)LT(0.013)AQNLS(0.044)LHS(0.219)GT(0.472)AT(0.208)PPLT(0.03)S(0.006)R 53.724 0.00073866 10035000.0 5837.4 3419.2 11436.0 20640.0 20760.0 13582.0 8281.7 13552.0 11766.0 19782.0 True False 5512.980676963669 3681.4416455391706 10700.220210575359 17828.79639401403 18151.943203245242 15452.79721487966 8666.815459877225 13591.434076345624 14119.528769508093 19210.842260191428 0.2869723566669239 0.19163353671212158 0.5569886039170848 0.928059069588986 0.9448801336971868 0.8043789546333863 0.4511418782421914 0.7074876724436855 0.7349770810812642 1.0 14.229633151960677 -5.454866552532854 3.7120558044090526 0.7753974816936847 0.24519174033781596 0.6860666797748621 0.14930429587149682 0.14303538758760648 3.8025317286871068 0.0439039272208587 0.09595713071907926 3.508596674962249e-06 5.454866552532854 -0.5302057413558687 QPTAEGSGSDAHSVESLTAQNLSLHSGTAT(ph)PPLTSR ddPTM_A459_Selumetinib_30min_R2 1 QPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSR 36 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 QPTAEGS(0.001)GS(0.001)DAHS(0.006)VES(0.058)LT(0.058)AQNLS(0.024)LHS(0.254)GT(0.254)AT(0.314)PPLT(0.02)S(0.01)R 42.38399999999999 0.029846 10378000.0 2860.2 5557.8 14565.0 20895.0 22142.0 8428.5 8705.6 13601.0 13090.0 11900.0 True False 2701.2415342877784 5984.065388856342 13627.903757172964 18049.0649541145 19360.324008008472 9589.449368694839 9110.427649819138 13640.576658233238 15708.365765159002 11556.416080086843 0.2337438800721581 0.5178132517370708 1.179250008197226 1.5618220068430477 1.6752878984141757 0.8297944018490876 0.7883436860254235 1.180346619895217 1.3592765833541154 1.0 13.496406432651801 -5.169949858900176 3.2752042467654987 1.2086359974331096 0.2861246949866283 0.6015494578524838 0.27137042965510993 0.1868386703255749 3.75796383661933 0.07999404071866423 0.26369582599124586 6.761610364827118e-06 5.169949858900176 -0.9225113024464813 QPVSEPPADQVASDMPHS(ph)PTLR ddPTM_A459_Selumetinib_30min_R1 1 QPVSEPPADQVASDMPHSPTLR 22 0 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7C231;H7C2V9 H7BYY2 BCOR BCL-6 corepressor 1 QPVSEPPADQVAS(0.001)DMPHS(0.775)PT(0.224)LR 155.5 4.5762e-09 8061600.0 2295.3 2124.5 2169.6 2537.4 2871.9 1937.7 2625.3 2389.1 997.23 1906.1 True False 2348.776024123671 1875.7625523467464 1874.9802367597347 2094.2907228970753 2612.1371520751272 1918.2084972908326 2427.271507358844 2325.733307109501 1692.2264752025349 2150.7665019862775 1.0920646299607735 0.8721367710601968 0.8717730330224837 0.9737415572368987 1.2145145229213699 0.8918720351648248 1.1285611455809863 1.081350906740289 0.7868015768516613 1.0 11.070635191704907 -4.449267369958449 19.080672118037388 0.9878901071097943 3.73790570736561 0.06410173981668699 0.12520654898040157 270.32972049038915 74950.43215796458 0.030404701981006706 2187.6524700935893 3.5541244434508574e-05 4.449267369958449 2.750015600255816 QPVSEPPADQVASDMPHS(ph)PTLR ddPTM_A459_Selumetinib_30min_R2 1 QPVSEPPADQVASDMPHSPTLR 22 0 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7C231;H7C2V9 H7BYY2 BCOR BCL-6 corepressor 1 QPVSEPPADQVASDMPHS(0.78)PT(0.22)LR 169.7 4.8611e-12 15412000.0 12312.0 8766.1 12538.0 18060.0 19691.0 14893.0 16768.0 13734.0 12118.0 17195.0 True False 11627.748328841037 9438.431682545888 11731.318730342227 15600.19684476229 17217.24054022649 16944.375564806567 17547.74522516166 13773.963666213904 14541.938605209834 16698.53567202464 0.6963334125351611 0.5652251112268644 0.7025357768343675 0.934225440551508 1.0310628954771672 1.0147222425732687 1.0508553306599044 0.8248605708157798 0.8708511267591091 1.0 14.027433974983285 -5.718529034456616 3.4845751804884304 0.9653094958397647 0.631327580850018 0.7914239655044583 0.07274908567973662 0.10529556997170972 2.6219279486511757 0.022384046838965804 0.03955428586273184 1.911925499877457e-06 5.718529034456616 -0.3339819149897466 QPVYYDELDAASS(ph)SLRR ddPTM_A459_Selumetinib_30min_R1 1 QPVYYDELDAASSSLRR 17 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 QPVYYDELDAAS(0.204)S(0.593)S(0.204)LRR 63.158 0.025594 5250800.0 1393.3 1316.5 1314.0 1212.7 1139.5 1122.8 1372.2 1574.6 638.93 1213.8 True False 1425.761179110142 1162.363567975754 1135.5660172853477 1000.924710198346 1036.4324261950646 1111.505651420832 1268.6938492354416 1532.8364929783681 1084.2175443991412 1369.6030534132217 1.0410032129798246 0.8486864607077204 0.8291205356583979 0.7308137257024339 0.7567392782982966 0.8115531347939253 0.9263222990586201 1.119183028366028 0.7916290356517064 1.0 10.419542107882945 -7.403209211628778 4.651171932634736 0.9758866705886968 0.8287717058930482 0.24101870510382972 0.10772098964347637 0.31030324435796947 10.426782162912174 0.04747703861296407 0.031073041899206913 3.951762069312489e-08 7.403209211628778 -0.14711496469564866 QPVYYDELDAASS(ph)SLRR ddPTM_A459_Selumetinib_30min_R2 1 QPVYYDELDAASSSLRR 17 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 QPVYYDELDAAS(0.328)S(0.336)S(0.336)LRR 61.959 0.027878 3245200.0 9935.7 8893.6 10556.0 11201.0 8940.3 11734.0 10883.0 9440.3 8009.7 9062.9 True False 9383.51356975844 9575.710522568772 9876.8384525038 9675.404477197253 7817.1395867039255 13350.251989353403 11389.081064255392 9467.7697100742 9611.863809716895 8801.230528757904 1.0661592761487082 1.0879967853677126 1.122211084033234 1.0993240599235525 0.8881871189672315 1.5168619826206837 1.2940328090534297 1.0757324988975563 1.0921045390539719 1.0 13.103489530415116 QPYPSRPPFDNQHS(ph)QDLDSR ddPTM_A459_Selumetinib_30min_R2 2 QPYPSRPPFDNQHSQDLDSR 20 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 QPYPSRPPFDNQHS(0.996)QDLDS(0.004)R;QPYPSRPPFDNQHS(1)QDLDSR 113.08 0.00017143 21716000.0 52846.0 50567.0 54368.0 56567.0 50959.0 40108.0 51307.0 48941.0 45471.0 48298.0 True False 49909.03087929937 54445.32630146792 50870.02207140263 48862.47701648216 44557.07484075985 45632.512935826366 53692.87716289178 49083.41020738128 54566.47056589346 46903.51124672556 1.0640787768907947 1.160794253015948 1.0845674602869733 1.0417658660873361 0.9499731183530632 0.9729018515434081 1.1447517624096897 1.0464762424541916 1.1633770930039458 1.0 15.517408308017677 -5.585215843064001 4.384323947707264 1.0450196847347992 1.1148444478969017 0.14118383286470404 0.06706714826558548 0.3953036871177076 15.229980405744165 0.019367893151906606 0.03556264734882808 2.5988676126810743e-06 5.585215843064001 0.06982476316210251 QQAAYYAQT(ph)SPQGMPQHPPAPQGQ ddPTM_A459_Selumetinib_30min_R2 3 QQAAYYAQTSPQGMPQHPPAPQGQ 24 0 Q96AE4 Q96AE4 FUBP1 Far upstream element-binding protein 1 1 QQAAY(0.001)Y(0.008)AQT(0.533)S(0.458)PQGMPQHPPAPQGQ;QQAAYY(0.001)AQT(0.575)S(0.425)PQGMPQHPPAPQGQ;QQAAYYAQT(0.589)S(0.411)PQGMPQHPPAPQGQ 103.26 2.9161000000000008e-06 67528000.0 92618.0 78249.0 99082.0 113586.0 109992.0 79203.0 96035.0 98376.0 75436.0 89952.0 True False 87470.6623392299 84250.44668980878 92707.17199232489 98115.39085322084 96173.82161904381 90112.49431675124 100500.81778974239 98662.2578729765 90525.30785794782 87354.85203663637 1.0013257455069005 0.9644621303287698 1.0612710093475264 1.123181924823953 1.1009556925207633 1.031568278301912 1.1504892452635904 1.1294422184081754 1.036293986508978 1.0 16.414600217949477 -5.390604706375445 4.337953754112005 1.0888914668933534 0.983657410001488 0.40575218953478775 0.04639478114457528 0.19193470981434202 5.796256518363632 0.012028026717604268 0.02645568497346127 4.06813441160227e-06 5.390604706375445 -0.10523405689186538 QQAAYYAQTS(ph)PQGMPQHPPAPQGQ ddPTM_A459_Selumetinib_30min_R1 2 QQAAYYAQTSPQGMPQHPPAPQGQ 24 0 Q96AE4 Q96AE4 FUBP1 Far upstream element-binding protein 1 1 QQAAYY(0.002)AQT(0.148)S(0.849)PQGMPQHPPAPQGQ;QQAAYY(0.001)AQT(0.359)S(0.64)PQGMPQHPPAPQGQ 80.359 0.00016707 33529000.0 4999.3 5807.6 6983.7 6333.200000000001 6808.5 5739.3 7062.0 6811.299999999999 3769.9 6075.5 True False 5115.773963055577 5127.643492120007 6035.351898718178 5227.22550888774 6192.672377138307 5681.567852867461 6529.307654351183 6630.642197779475 6397.244957398029 6855.349605381476 0.7462455246687455 0.747976950452649 0.8803857200777044 0.7625031267237411 0.9033342912631378 0.8287787173403101 0.952439777721278 0.967221597651912 0.9331755965262759 1.0 12.743014526317793 -6.228327013236348 0.3275402807051198 1.0088508057184007 0.6798413984878833 0.7612903454591798 0.04418048925390287 1.308379946829691 0.2286636623538565 0.05057603106204961 0.16006555840979453 5.911163702363462e-07 6.228327013236348 -0.3290094072305174 QQAAYYAQTS(ph)PQGMPQHPPAPQGQ ddPTM_A459_Selumetinib_30min_R2 2 QQAAYYAQTSPQGMPQHPPAPQGQ 24 0 Q96AE4 Q96AE4 FUBP1 Far upstream element-binding protein 1 1 QQAAY(0.005)Y(0.044)AQT(0.408)S(0.544)PQGMPQHPPAPQGQ;QQAAY(0.001)Y(0.001)AQT(0.185)S(0.813)PQGMPQHPPAPQGQ 83.755 0.0002545 27428900.0 55824.0 45678.0 49502.0 62081.0 60624.0 45326.0 52708.0 56406.0 48143.0 51491.0 True False 52721.52556117789 49181.355722080676 46317.09521370246 53625.46070430162 53007.87113456358 51569.2450715385 55159.026438920584 56570.13212148403 57772.9452278113 50004.32104031528 1.0543393943629773 0.9835421159389186 0.9262618559776055 1.0724165349843837 1.0600658109491525 1.031295776018267 1.1030851992660673 1.1313048741502791 1.1553590574949049 1.0 15.609765147918385 -6.5526894094002 1.0130231237006548 1.1048449193297394 0.9944008730081486 0.3278255859577631 0.05419663124085121 0.5541186941729683 1.2248550270791851 0.02825742740050986 0.031927367380410916 2.8009837586600363e-07 6.5526894094002 -0.11044404632159077 QQADKESEVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 QQADKESEVSPSR 13 1 Q86SQ7-2;Q86SQ7-3;Q86SQ7-4;Q86SQ7 Q86SQ7-2 SDCCAG8 Serologically defined colon cancer antigen 8 1 QQADKESEVS(0.938)PS(0.062)R;QQADKES(0.002)EVS(0.974)PS(0.024)R 172.43 0.00083507 6623400.0 1252.9 1328.92 1295.31 1284.03 1341.92 921.21 1225.5500000000002 1029.79 639.6 1051.46 True False 1282.090132280986 1173.3294286018524 1119.414016628527 1059.7982647282774 1220.543572935218 911.9434637917575 1133.105776804034 1002.4766239706554 1085.3544854642766 1186.425133087713 1.0806329843538474 0.9889620473128561 0.9435184618141161 0.8932702411403872 1.0287573475105931 0.768648133252532 0.9550588108792726 0.8449556537644097 0.91481076655853 1.0 10.212405349769684 -3.676646368071416 0.719309562177121 0.9033247006891898 1.803455033356712 0.34382764919860476 0.07018481444609258 12.471385091828466 1.4687514173028682 0.02594245626658169 13.13318342555385 0.00021054921760279023 3.676646368071416 0.9001303326675223 QQASKS(ph)PYNGVR ddPTM_A459_Selumetinib_30min_R1 2 QQASKSPYNGVR 12 1 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 1 QQAS(0.028)KS(0.972)PYNGVR;QQAS(0.018)KS(0.982)PYNGVR 178.68 0.0004927 23944500.0 2349.0 2286.98 2855.1 3043.6 2747.9300000000003 2158.15 2416.0 2445.0 1468.75 1953.54 True False 2403.7271296416593 2019.2193184118419 2467.393101941701 2512.092395447913 2499.3802166864466 2136.4409704434183 2233.7591748672403 2380.1506575207127 2492.361476744305 2204.2958880910096 1.0904738980951252 0.9160382366636587 1.119356577885985 1.1396348416833755 1.1338678396986845 0.9692169649210044 1.0133663030155842 1.079778205085706 1.1306837209149674 1.0 11.106102178094726 -7.0848641637687955 0.0016183089637413408 0.2859962763858791 1.832516512988412 0.0067070143466541055 0.07482967271935849 1740728.10563507 1457.4173048322396 694186.2752371517 698556.4632335224 8.224998666885333e-08 7.0848641637687955 1.5465202366025328 QQDLHLES(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 QQDLHLESPQR 11 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 QQDLHLES(1)PQR 96.414 0.013397999999999998 6808700.0 7091.4 8160.1 4910.3 4199.6 6280.5 5709.1 7466.3 8231.0 4699.2 7732.5 True False 7256.615822537617 7204.711698472426 4243.508230347219 3466.2186962554415 5712.429883912337 5651.67163744805 6903.110979847386 8012.687141943954 7974.199184011465 8725.041695928276 0.8316998445891748 0.825750976277243 0.4863596505593253 0.3972724506145369 0.6547166286412318 0.6477529660500674 0.7911837238633334 0.9183551690856954 0.9139439628962224 1.0 13.090946310467496 -7.537020453461051 1.7570014383301622 0.9536989921435215 0.6275640030114794 0.5414714543142627 0.12580696854324164 0.32672621422975173 1.9714470499201167 0.09142202774833122 0.044584130426555714 2.903885890314621e-08 7.537020453461051 -0.3261349891320421 QQDLHLES(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 QQDLHLESPQR 11 0 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 QQDLHLES(1)PQR 118.73 0.0052246 16804000.0 50805.0 34991.0 50822.0 57381.0 71681.0 56032.0 62054.0 64027.0 66377.0 46744.0 True False 47981.46148852899 37674.697186201745 47552.16785080977 49565.60881225383 62675.79194372934 63749.89939214675 64939.63395766828 64213.30796975957 79654.25472833918 45394.379264502466 1.0569912457432715 0.829941895816662 1.047534267926308 1.091888679068538 1.3806949882172 1.4043566720163954 1.4305655239667487 1.4145651732696594 1.7547162450269977 1.0 15.470226053514171 -6.13975098195984 1.7042719144885758 1.4335533285038182 0.950774651766891 0.5342536091515204 0.18013952360720098 0.25721238016370845 1.4835004000202214 0.05924241466689575 0.08738455748396431 7.248514600619135e-07 6.13975098195984 -0.4827786767369272 QQDLHLES(ph)PQRQPEYS(ph)PESPR ddPTM_A459_Selumetinib_30min_R1 1 QQDLHLESPQRQPEYSPESPR 21 1 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 2 QQDLHLES(0.944)PQRQPEY(0.113)S(0.936)PES(0.007)PR 63.563 0.024227 34583000.0 1842.9 1599.3 2033.3 2269.5 2030.9 1716.2 2135.3 1764.6 1020.3 1520.8 True False 1885.8359843408305 1412.0532125056016 1757.189028117426 1873.1744287912477 1847.2054535845166 1698.936586184923 1974.2326018601075 1717.7970757713888 1731.3745802364012 1716.0094938464567 1.0989659387686168 0.822870279895985 1.0239972648278681 1.0915874507153827 1.0764540990061673 0.9900508081553415 1.150478834143767 1.001041708645169 1.0089539635095512 1.0 10.74484181925206 -5.504767425201684 24.95343375149591 1.0495888822937598 0.9515470181813283 0.1510280757592264 0.07808092426373223 1045.3790663902128 1440301.4819643795 0.019252236503017026 0.038878931475904176 3.1277539036855606e-06 5.504767425201684 -0.09804186411243154 QQDLHLES(ph)PQRQPEYSPES(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QQDLHLESPQRQPEYSPESPR 21 1 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 2 QQDLHLES(0.994)PQRQPEY(0.063)S(0.364)PES(0.579)PR 53.184 0.031521 9024700.0 38883.0 32927.0 42961.0 47493.0 54511.0 42875.0 30103.0 37877.0 34870.0 40917.0 True False 36722.038520981674 35452.39502300779 40196.9360324001 41024.37147000525 47662.84084547697 48780.642069501235 31502.849147962857 37987.21579912509 41844.9743492051 39735.61989486665 0.9241591956572371 0.8922069195550112 1.0116096373670278 1.0324331564110087 1.1994991136814859 1.2276300759511516 0.7928113171837703 0.955999073366226 1.0530847249877924 1.0 15.278145230893305 -5.365456587809693 3.7688371095341764 1.0390488190553406 0.9077472672586294 0.16399253782106926 0.11458569861022101 0.45196075375463657 11.472863029851775 0.033799962259085735 0.07810438897744022 4.310656452864035e-06 5.365456587809693 -0.1313015517967112 QQDLHLES(ph)PQRQPEYSPESPR ddPTM_A459_Selumetinib_30min_R1 1 QQDLHLESPQRQPEYSPESPR 21 1 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 QQDLHLES(0.993)PQRQPEY(0.001)S(0.005)PESPR 69.649 0.0029075 20971000.0 3909.9 3800.6 4429.3 4158.8 4897.6 3847.2 4805.3 4065.8 2470.2 3265.3 True False 4000.9930626589726 3355.623985148996 3827.8253884033434 3432.5436503445876 4454.612944741507 3808.500660978113 4442.832352230774 3957.96177642033 4191.748983730233 3684.4330617154324 1.0859182391540458 0.9107572125592244 1.0389184236179743 0.9316341463797505 1.2090361990909633 1.033673457268597 1.205838802825811 1.0742390240569455 1.1376917190561198 1.0 11.847226927869372 -6.251013539735002 24.996311860957437 1.114759446423187 0.9893828365143775 0.35625028516236745 0.07770829233960953 712.3996404126895 1708001.2210565 0.02105622975899037 0.026885637927021717 5.610304848535082e-07 6.251013539735002 -0.1253766099088094 QQDLHLES(ph)PQRQPEYSPESPR ddPTM_A459_Selumetinib_30min_R2 3 QQDLHLESPQRQPEYSPESPR 21 1 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 QQDLHLES(0.998)PQRQPEYS(0.001)PESPR;QQDLHLES(0.999)PQRQPEY(0.001)S(0.001)PESPR;QQDLHLES(0.988)PQRQPEY(0.005)S(0.006)PESPR 66.264 0.0040387 86591900.0 342445.0 310903.0 356537.0 392306.0 415285.0 331033.0 355636.0 347354.0 298871.0 340894.0 True False 323413.27781594935 334748.2603892915 333597.79758813453 338873.24603440246 363113.18560499523 376629.7909316193 372173.77867936523 348364.74263244995 358653.5511534626 331051.50447101815 0.9769273767014779 1.011166709313647 1.0076915316279413 1.0236269627467258 1.0968480151908928 1.1376773276817755 1.1242171494555075 1.0522977178100923 1.0833768954669134 1.0 18.3366961611505 -6.134995638762883 3.449816300457842 1.0898731450146908 1.0013646218846592 0.5110822182769786 0.037212770796545794 0.19594161713741579 4.293984165719791 0.011513598693346986 0.015421433461580139 7.32831892287443e-07 6.134995638762883 -0.08850852313003155 QQDPSPGS(ph)NLGGGDDLK ddPTM_A459_Selumetinib_30min_R2 1 QQDPSPGSNLGGGDDLK 17 0 J3KTD8;Q13951-2 J3KTD8 CBFB 1 QQDPS(0.239)PGS(0.761)NLGGGDDLK 134.08 0.0005803 4822000.0 89021.0 87320.0 93743.0 91016.0 88592.0 68765.0 73873.0 79338.0 62591.0 75188.0 True False 84073.56919929822 94017.16322194684 87711.67743966107 78619.46378864253 77462.28093747118 78236.75456348111 77308.24087657254 79568.86044488699 75110.94893866054 73017.12707811497 1.1514225848595068 1.287604251004914 1.2012479941291805 1.076726337158323 1.0608782355213828 1.0714849747482136 1.0587685926600052 1.0897287202187902 1.0286757634041883 1.0 16.155947285357378 -5.754631884337596 3.8261966063656883 1.058326150963521 1.2252109056683615 0.781196043968672 0.0385156359682063 0.08875565734925682 2.8316167471263456 0.010204665539007389 0.017305661114999205 1.7594142926914857e-06 5.754631884337596 0.16688475470484065 QQELTHQEHR ddPTM_A459_Selumetinib_30min_R1 2 QQELTHQEHR 10 0 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 0 ; 186.81 8.2946e-05 1648920.0 1293.28 1629.5900000000001 1618.4900000000002 1345.1299999999999 1544.8600000000001 1558.74 1234.07 1494.02 1365.53 1638.21 False True 1323.4109077151822 1438.7968452241623 1398.7079477291961 1110.2282967173255 1405.1276857671858 1543.0604908226826 1140.9831063445429 1454.3937363390978 2317.204675634827 1848.490211016704 0.7159415288368131 0.7783632483684062 0.7566758749346477 0.6006135656551188 0.7601488378963821 0.8347680077645478 0.6172513652192839 0.7868008862969061 1.2535661059088439 1.0 10.852131688179101 -8.162571093935497 5.601014161962427 1.1226140629374852 0.7266819719666059 0.7642333330915395 0.08822899743771513 0.09391604774993124 4.192069095992183 0.05955971578537192 0.021633671962065535 6.877473189699246e-09 8.162571093935497 -0.39593209097087934 QQELTHQEHR ddPTM_A459_Selumetinib_30min_R2 3 QQELTHQEHR 10 0 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 0 ;; 95.775 0.012638 15531100.0 42100.2 37803.1 27674.7 32990.2 39679.7 31227.8 46060.0 52319.0 44289.0 52205.0 False True 39760.43942445368 40702.4762138751 25894.139931935082 28496.877848730706 34694.78134498121 35529.14599225584 48201.88126615855 52471.239628123265 53148.037538054035 50697.706005120475 0.784265059654531 0.8028465076854592 0.510755652914942 0.5620940293798011 0.684346178138258 0.7008038191839961 0.9507704601326566 1.0349825221445654 1.0483321973717328 1.0 15.62963284847607 -7.308530989518782 2.548045090944092 1.030592967068631 0.6618678016632915 0.7969707394362568 0.08341631744470278 0.1404443260263264 1.7938809473921968 0.044555580049891005 0.02864220924428636 4.914383118739739e-08 7.308530989518782 -0.3687251654053394 QQFILT(ph)SPDGAGTGK ddPTM_A459_Selumetinib_30min_R2 2 QQFILTSPDGAGTGK 15 0 P49116;P49116-2;C9JKS0;C9JMI6 P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 1 QQFILT(0.873)S(0.127)PDGAGTGK;QQFILT(0.5)S(0.5)PDGAGTGK 220.27 5.0268e-09 9510500.0 85409.0 83790.0 94650.0 96987.0 99996.0 80343.0 84738.0 88077.0 77403.0 77935.0 True False 80662.30969931658 90216.4235726857 88560.32204712793 83777.20328809293 87433.60850441773 91409.51896886155 88678.48490516144 88333.2894880678 92885.76282051962 75684.81405055201 1.065766107920143 1.1920016545515673 1.1701200981741993 1.106922231877795 1.155233181203542 1.2077656543861832 1.1716813474091459 1.167120387308708 1.2272708070403477 1.0 16.207716236011812 -6.518950986595605 24.867812053051864 1.1679619518079851 1.1392942136571889 0.00177794965868594 0.06596231610320878 600.0878353811487 3799357.7571351742 0.020280254745779148 0.020718489633653164 3.02725505736475e-07 6.518950986595605 -0.028667738150796263 QQFSPS(ph)MTER ddPTM_A459_Selumetinib_30min_R1 2 QQFSPSMTER 10 0 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 QQFS(0.08)PS(0.914)MT(0.006)ER;QQFS(0.18)PS(0.804)MT(0.016)ER 143.42 0.0010914000000000002 15889400.0 4870.7 3920.7 4725.5 5114.5 5250.3 4489.5 4785.6 4555.5 2878.8999999999996 3829.8 True False 4984.177833267618 3461.6626213160207 4083.803055313479 4221.348586055447 4775.411292015755 4444.339706139854 4424.6183390913375 4434.673341650551 4885.283033463269 4321.392135411072 1.153373190186893 0.8010526498972144 0.9450202451773121 0.9768492314002631 1.105063170010489 1.028450917407218 1.0238872568018977 1.0262140538719484 1.1304882501709272 1.0 12.077280435780448 -6.077363898693841 5.910280283695147 1.0508364582069845 0.9514743511168248 0.17183018682606366 0.08784091876297956 0.3446633875902428 20.490897367897777 0.02497108888875314 0.032726257338022466 8.368278038139657e-07 6.077363898693841 -0.09936210709015969 QQGFNYCTSAISS(ph)PLTK ddPTM_A459_Selumetinib_30min_R2 1 QQGFNYCTSAISSPLTK 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 QQGFNYCTSAIS(0.012)S(0.988)PLTK 160.03 2.8134e-05 4181800.0 24848.0 17774.0 22836.0 28632.0 31617.0 25818.0 30508.0 25959.0 23693.0 29647.0 True False 23467.047634425136 19137.208647582236 21366.756621956865 24732.272207045044 27644.98980043376 29374.195147530787 31926.68245045516 26034.5363922562 28432.262037732038 28791.014077843247 0.8150823576750884 0.6646938032762691 0.7421328253387267 0.8590274778156669 0.960195070784553 1.0202556626908235 1.1089113556102574 0.9042590970177616 0.9875394441077608 1.0 14.813330983987797 -6.064861148792561 1.979772596570284 1.0032022096379076 0.7301319337050985 0.7986630153394632 0.05819445997558954 0.14205509055456791 1.1073800758247776 0.019572734503536898 0.02962158059260637 8.612690702928843e-07 6.064861148792561 -0.2730702759328091 QQGHEPVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 QQGHEPVSPR 10 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 QQGHEPVS(1)PR;QQGHEPVS(1)PR 113.37 0.0050736 42430000.0 6637.2 7469.9 5712.5 6278.0 5810.0 6211.700000000001 7001.0 6391.3 3844.99 5803.6 True False 6791.833846256966 6595.3206353377045 4936.773876516397 5181.66515265541 5284.486525838812 6149.215937772343 6472.908933462565 6221.781962131749 6524.66720304142 6548.548591851195 1.0371510191904978 1.007142352664942 0.7538729853298425 0.791269253022465 0.8069706518501913 0.9390196700111886 0.9884494010653363 0.9501009078368811 0.9963531783455815 1.0 12.67695947049235 -6.975636405046082 9.14755018997066 0.9773647687556665 0.874271535688165 0.25130012338409147 0.08475799094346538 0.4326305321300967 149.33519602476588 0.03371947233551104 0.02951298862635267 1.0577026561003863e-07 6.975636405046082 -0.10309323306750151 QQGHEPVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 QQGHEPVSPR 10 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 QQGHEPVS(1)PR 70.889 0.048094 5553100.0 9444.6 8705.8 11254.0 11786.0 10886.0 7658.1 9832.6 8854.9 8516.9 9938.7 True False 8919.706941729382 9373.506866440952 10529.92989242873 10180.72646801596 9518.403357925226 8712.93376168973 10289.83538292728 8880.666292992391 10220.517982068963 9651.743907156231 0.9241549535018139 0.9711723556497409 1.0909872862065242 1.0548069412065024 0.986184823124851 0.902731552505198 1.0661115215974535 0.920110021403269 1.0589296691234231 1.0 13.2365739212293 -6.4748189816094905 24.743978150734716 0.9843769495028624 1.0141572596745057 0.02159160475464106 0.06386102376373305 1323.427855632118 681378.0965305582 0.020055083480081875 0.02273982298482159 3.35105085286389e-07 6.4748189816094905 0.029780310171643287 QQLPQT(ph)PPSCLK ddPTM_A459_Selumetinib_30min_R2 1 QQLPQTPPSCLK 12 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 QQLPQT(1)PPSCLK 136.24 0.0033284 35842000.0 43862.0 36639.0 34698.0 44102.0 46254.0 40723.0 41860.0 41157.0 32699.0 38486.0 True False 41424.32563349786 39449.093487046564 32465.56845632596 38095.231519806555 40443.159003993525 46332.22360341219 43806.57294401642 41276.76005609187 39239.71368639683 37374.80918136323 1.1083488194544122 1.0554995289907103 0.8686484069733997 1.019275612483998 1.082096735470701 1.2396644857391148 1.172088203352229 1.104400556422756 1.0498973652543364 1.0 15.18977859313969 -6.357983410895821 3.920645886332392 1.1261499599851472 1.005516225199638 0.23139447138799207 0.08346557777192397 0.310758880729589 8.65254918281651 0.02789663965477531 0.032113943116420435 4.38547449013321e-07 6.357983410895821 -0.12063373478550932 QQLS(ph)AEELDAQLDAYNAR ddPTM_A459_Selumetinib_30min_R2 1 QQLSAEELDAQLDAYNAR 18 0 E9PB61;Q86V81 E9PB61 ALYREF THO complex subunit 4 1 QQLS(1)AEELDAQLDAYNAR 103.73 0.0019874000000000003 5416700.0 1523.2 3784.0 5465.0 4221.3 4142.8 4093.6 3457.1 5783.4 3103.1 5931.5 True False 1438.546641852719 4074.220632522288 5113.387849842104 3646.3516578513313 3622.3444268980934 4657.456241999071 3617.8620001136915 5800.228736506587 3723.806707858281 5760.242183112191 0.24973718050783225 0.7073002320053554 0.8877036220514257 0.6330205470425638 0.6288528002378163 0.8085521570002291 0.6280746338618358 1.0069418180908483 0.6464670389685512 1.0 12.491913754147356 -4.768479073945076 4.337991838261801 0.7670810834129735 0.2058078833923189 0.5551860908132666 0.14112432468968597 0.15238523704513546 6.00867259876273 0.03350084940740975 0.26800699096828334 1.7042014326167786e-05 4.768479073945076 -0.5612732000206546 QQLS(ph)EEEK ddPTM_A459_Selumetinib_30min_R2 1 QQLSEEEK 8 0 Q8WVC0-2;Q8WVC0 Q8WVC0-2 LEO1 RNA polymerase-associated protein LEO1 1 QQLS(1)EEEK 104.82 0.014415 14065000.0 70401.0 31876.0 40126.0 71124.0 52836.0 54746.0 116360.0 134130.0 84004.0 37821.0 True False 66488.39425753229 34320.78670250544 37544.336845885475 61436.78850425653 46198.269320166946 62286.76456529241 121770.97056296567 134520.2960935832 100807.14726786992 36729.009459240726 1.8102419650417318 0.9344326789044566 1.0221984583480135 1.6727047477943766 1.257814191026157 1.6958465660342374 3.3153894525279406 3.6625081393187138 2.7446192737579436 1.0 15.16463236825417 -7.122611201958946 4.517559306698481 2.8946592925044525 1.3305251953947552 0.43433004903158057 0.7074820372711647 0.1822366743025114 5.892433193788107 0.26670893578974686 0.2051687223173812 7.540303001813146e-08 7.122611201958946 -1.5641340971096973 QQLS(ph)PDRQPQSSGPDR ddPTM_A459_Selumetinib_30min_R1 1 QQLSPDRQPQSSGPDR 16 1 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 QQLS(0.733)PDRQPQS(0.201)S(0.066)GPDR 105.53 0.017337 3578400.0 735.95 838.77 624.69 993.66 828.09 675.39 797.62 796.84 468.17 632.02 True False 753.0962030905831 740.5664184664058 539.8605291765481 820.135934308311 753.1894057111643 668.5961898050548 737.4548812324535 775.7052146988975 794.4502962160889 713.1459233961316 1.0560197827454456 1.0384500481187535 0.757012711515805 1.1500254119138387 1.0561504749607742 0.937530690242296 1.0340869337379905 1.0877229880314636 1.1140080454120398 1.0 9.478053499851956 -7.538795417877378 6.271745705189925 1.073537767134765 0.9982778067500948 0.08436064816673194 0.10024130159630656 0.39626517594011035 60.76474604949678 0.04740806040404417 0.027971244594990032 2.8920419091998798e-08 7.538795417877378 -0.0752599603846702 QQLS(ph)PDRQPQSSGPDR ddPTM_A459_Selumetinib_30min_R2 1 QQLSPDRQPQSSGPDR 16 1 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 QQLS(0.851)PDRQPQS(0.131)S(0.018)GPDR 141.34 0.0018855 4001400.0 7447.7 6277.5 7183.0 8331.1 9177.7 6936.5 6546.7 8138.9 6258.9 8449.1 True False 7033.78664950531 6758.964064656101 6720.853600259072 7196.3898080508925 8024.715276320999 7891.939911722335 6851.134522039945 8162.582851532575 7510.854888277592 8205.152529601828 0.8572402065811005 0.8237463033467939 0.8191016042678264 0.8770574077798542 0.9780092749488978 0.961827325360557 0.8349795445389985 0.994811835865857 0.9153827258153447 1.0 13.002314437615553 -6.035594826114085 4.363620758650298 0.941992171002655 0.8336249061670722 0.5606930832723868 0.045771400994553325 0.16068000661365722 6.968481848375505 0.013438849459925555 0.01855267470239687 9.213087034417434e-07 6.035594826114085 -0.10836726483558279 QQLS(ph)PSPGQEAGILPETEK ddPTM_A459_Selumetinib_30min_R1 3 QQLSPSPGQEAGILPETEK 19 0 E5RJM0;B7ZLQ8;Q17RY0-2;Q17RY0 E5RJM0 CPEB4 Cytoplasmic polyadenylation element-binding protein 4 1 QQLS(0.924)PS(0.076)PGQEAGILPETEK;QQLS(0.991)PS(0.009)PGQEAGILPETEK;QQLS(0.5)PS(0.5)PGQEAGILPETEK 208.87 1.8999999999999998e-16 14416500.0 7271.49 8243.41 9407.75 8592.820000000002 8446.76 7875.150000000001 7263.72 8239.970000000001 5120.9800000000005 6784.7 True False 7440.901569143476 7278.2677249426615 8130.229223071717 7092.245294208416 7682.752049396605 7795.933141064098 6715.811752345479 8021.419228405296 8689.9290384191 7655.582333574467 0.9719576179738172 0.9507137939099619 1.0620001025154715 0.9264148676325419 1.003549007069388 1.0183331327878358 0.8772437496873997 1.0477869453805504 1.1351101274567166 1.0 12.902296407365117 -7.983374468931712 24.99106858644645 1.0755195879719994 0.9755956436398328 0.3381188991785471 0.0566145211340356 224.48489925024998 337439.8028147554 0.029332484271661935 0.014084517013993745 1.0390238846858585e-08 7.983374468931712 -0.09992394433216667 QQLS(ph)PSPGQEAGILPETEK ddPTM_A459_Selumetinib_30min_R2 3 QQLSPSPGQEAGILPETEK 19 0 E5RJM0;B7ZLQ8;Q17RY0-2;Q17RY0 E5RJM0 CPEB4 Cytoplasmic polyadenylation element-binding protein 4 1 QQLS(0.826)PS(0.174)PGQEAGILPETEK;QQLS(0.683)PS(0.317)PGQEAGILPETEK;QQLS(0.624)PS(0.376)PGQEAGILPETEK 188.56 3.5256999999999997e-15 25939000.0 138108.0 115076.0 131944.0 148185.0 147078.0 94220.0 109954.7 115872.0 95125.0 113380.0 True False 130432.51025012817 123901.95917233996 123454.86668976543 128001.94736661672 128600.7467459974 107197.94975599767 115067.81142110455 116209.1683363578 114152.65801457208 110106.4248033821 1.1846039909391528 1.1252927283180127 1.1212321797771543 1.1625293219282233 1.1679676910374734 0.9735848743379133 1.045059919315172 1.0554258622407677 1.0367483842874325 1.0 16.748539128275922 -6.751185402499948 24.999999999315605 1.0270589293188088 1.1496629054691216 0.8416763003262566 0.02817442451214522 84.98666878874539 207203.88972151885 0.009591774665297812 0.00948886284812168 1.7734322321201737e-07 6.751185402499948 0.12260397615031282 QQLSPDRQPQS(ph)SGPDR ddPTM_A459_Selumetinib_30min_R1 1 QQLSPDRQPQSSGPDR 16 1 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y307 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 QQLS(0.033)PDRQPQS(0.934)S(0.033)GPDR 173.19 2.3725e-05 5107600.0 1508.0 1460.4 1546.9 1549.9 1515.8 1407.0 1413.3 1484.2 838.11 1370.6 True False 1543.1334659427926 1289.4156890784589 1336.8394765134735 1279.2390602262858 1378.6961576362257 1392.846857453787 1306.693643145642 1444.8341946389523 1422.2114568675197 1546.5298607745613 0.9978038608125758 0.8337476836255009 0.8644123275084603 0.8271673846540499 0.8914772308022051 0.9006271995008205 0.8449197628109165 0.9342426753501701 0.9196146113565643 1.0 10.594818974264806 -8.557859833704184 1.0076319882654654 0.9986533899483477 0.8767910506624194 0.35330453782527604 0.04769134152524676 0.630304077615604 1.3996283133541676 0.04402075609545462 0.014566553172892918 2.767834805627571e-09 8.557859833704184 -0.12186233928592838 QQLSPS(ph)PGQEAGILPETEK ddPTM_A459_Selumetinib_30min_R1 2 QQLSPSPGQEAGILPETEK 19 0 E5RJM0;B7ZLQ8;Q17RY0-2;Q17RY0 E5RJM0 CPEB4 Cytoplasmic polyadenylation element-binding protein 4 1 QQLS(0.305)PS(0.695)PGQEAGILPETEK;QQLS(0.436)PS(0.564)PGQEAGILPETEK 206.8 2.4568e-16 13573800.0 6920.4 7374.1 8467.5 8167.7 7939.1 7705.299999999999 7742.799999999999 7696.1 4731.6 6531.4 True False 7081.631855245695 6510.736943873913 7317.660008648157 6741.364521717681 7221.009806761948 7627.791677852632 7158.754362235956 7491.974427544032 8029.179617609091 7369.768811223529 0.9609028500949682 0.8834384240057322 0.9929293843660313 0.9147321570591411 0.9798149700116734 1.0350109851799092 0.9713675619422124 1.0165820149112945 1.0894751006817658 1.0 12.847403647519373 -6.6163444139673615 0.8341204369690225 1.0324382805291996 0.9290673850808175 0.4878581961460895 0.03968024552858419 0.5205582068834651 0.7998446242990098 0.023898464265774483 0.026465325687998364 2.419109828999287e-07 6.6163444139673615 -0.10337089544838207 QQLSPS(ph)PGQEAGILPETEK ddPTM_A459_Selumetinib_30min_R2 3 QQLSPSPGQEAGILPETEK 19 0 E5RJM0;B7ZLQ8;Q17RY0-2;Q17RY0 E5RJM0 CPEB4 Cytoplasmic polyadenylation element-binding protein 4 1 QQLSPS(1)PGQEAGILPETEK;QQLS(0.238)PS(0.762)PGQEAGILPETEK;QQLS(0.048)PS(0.952)PGQEAGILPETEK 215.64 7.8898e-18 14774600.0 130358.0 125054.0 134376.0 160785.0 167937.0 120126.0 133602.0 131352.0 106718.0 132228.0 True False 123113.2242244202 134645.2396880134 125730.39445752677 138885.80563040441 146839.2526841713 136672.26610474402 139814.75772734082 131734.2125735059 128064.58195005631 128410.2340703972 0.958749317106041 1.048555363696308 0.9791306383617268 1.08157894606955 1.1435167434059106 1.0643409156143848 1.0888131988817296 1.0258856198430917 0.9973082198405511 1.0 16.970400661743106 -4.131584130145184 0.9887890825884301 1.0581035109666592 0.7367078538530283 0.22876457058078026 0.04762306166814428 9.093065454624735 2.865865589036507 0.016230867388977752 4.23672744972578 7.38611167728826e-05 4.131584130145184 -0.32139565711363094 QQPPEPEWIGDGES(ph)TSPSDKVVK ddPTM_A459_Selumetinib_30min_R1 1 QQPPEPEWIGDGESTSPSDKVVK 23 1 Q5STZ8;Q8NE71;Q8NE71-2;A0A0G2JIC2 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 QQPPEPEWIGDGES(0.384)T(0.384)S(0.23)PS(0.001)DKVVK 114.05 6.3612e-06 52653000.0 3119.6 3156.7 5271.7 6209.9 4504.8 4247.1 4229.3 3918.6 2165.5 3334.4 True False 3192.2806103150783 2787.112096489984 4555.832095375316 5125.4575392600855 4097.341635387038 4204.378030058265 3910.2804959710356 3814.6659985933193 3674.6953381377293 3762.4027198064323 0.8484686111643345 0.7407798431087077 1.2108836917940842 1.3622830730687383 1.0890226114863741 1.117471558247909 1.03930407964733 1.0138909315878806 0.9766884652706143 1.0 11.877438564882015 -5.256077265591152 24.978332546420113 1.1089501974582305 0.7946242005748462 0.5470971766441071 0.11139404173475345 339.67912955694874 1582314.4930258133 0.0314706429156826 0.07832197955557288 5.545270479424732e-06 5.256077265591152 -0.31432599688338436 QQPPEPEWIGDGEST(ph)SPSDKVVK ddPTM_A459_Selumetinib_30min_R1 3 QQPPEPEWIGDGESTSPSDKVVK 23 1 Q5STZ8;Q8NE71;Q8NE71-2;A0A0G2JIC2 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 QQPPEPEWIGDGES(0.167)T(0.514)S(0.316)PS(0.002)DKVVK;QQPPEPEWIGDGES(0.11)T(0.698)S(0.189)PS(0.003)DKVVK;QQPPEPEWIGDGES(0.227)T(0.633)S(0.14)PSDKVVK 123.03 1.4494e-05 106664000.0 9218.900000000001 10519.8 17449.6 17646.1 14036.9 12758.0 12053.0 10771.3 6823.7 8033.099999999999 True False 9433.682433143244 9288.136925477665 15080.040163791784 14564.539893321544 12767.264873415974 12629.666103337173 11143.832506074028 10485.610133886645 11579.320516670716 9064.226634020226 1.0407597706942102 1.0247026360326263 1.6636874575921083 1.6068155046628376 1.4085332802135986 1.3933528599047815 1.2294300392102444 1.1568124405155122 1.2774747349333408 1.0 13.145968218160485 -7.4245612173831335 3.3585612503076563 1.1650345445592762 1.3688273050727535 0.178748441738786 0.20303285917072067 0.5229888920620722 11.096976536046858 0.10584231057787748 0.06576774606895026 3.762173176013893e-08 7.4245612173831335 0.20379276051347728 QQPPEPEWIGDGESTS(ph)PSDK ddPTM_A459_Selumetinib_30min_R2 1 QQPPEPEWIGDGESTSPSDK 20 0 Q5STZ8;Q8NE71;Q8NE71-2;A0A0G2JIC2 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 QQPPEPEWIGDGES(0.001)T(0.184)S(0.631)PS(0.184)DK 124.88 0.00015309 6962000.0 96664.0 68973.0 80119.0 95482.0 85957.0 87027.0 101440.0 103290.0 81377.0 77489.0 True False 91291.8018566513 74263.00731684983 74964.2307669715 82477.18688436285 75158.31319467009 99014.1792975507 106157.16099954667 103590.55679942 97654.67386335706 75251.69122939908 1.2131528257398916 0.9868616386369934 0.9961800132630736 1.0960177178335753 0.9987591237724568 1.3157734753856027 1.4106946869264987 1.376587756461606 1.2977073640200882 1.0 16.199436385353337 -6.768265714506176 24.983693756376915 1.3118483220189256 1.0528874002801192 0.44115955725550526 0.12226070582832078 124.79977337843276 456751.4736870103 0.04064982225918976 0.03663244385412681 1.705038875429062e-07 6.768265714506176 -0.25896092173880647 QQPPEPEWIGDGESTS(ph)PSDKVVK ddPTM_A459_Selumetinib_30min_R1 1 QQPPEPEWIGDGESTSPSDKVVK 23 1 Q5STZ8;Q8NE71;Q8NE71-2;A0A0G2JIC2 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 QQPPEPEWIGDGES(0.223)T(0.223)S(0.552)PS(0.002)DKVVK 106.62 1.1028e-05 10633000.0 2425.4 2889.3 4077.0 4311.7 4157.2 3268.1 3253.7 3320.2 1601.1 2361.5 True False 2481.907100993138 2551.0194128008716 3523.3657933579607 3558.742535633057 3781.1819940132705 3235.225881197384 3008.270789431102 3232.137510470458 2716.949760282762 2664.621527957922 0.9314295013202831 0.9573665100408795 1.3222762618968076 1.3355527223261459 1.4190315413803039 1.2141408628777215 1.1289673816215624 1.212981834965306 1.0196381481481698 1.0 11.379714917641435 -8.27933209735206 7.366188637389066 1.0080802560136926 1.1981546665026477 0.19155473364035402 0.14752780615083727 0.3528583146372964 99.08777615992715 0.14447166242051282 0.041451071136670056 5.256151839908052e-09 8.27933209735206 0.19007441048895513 QQPPEPEWIGDGESTS(ph)PSDKVVK ddPTM_A459_Selumetinib_30min_R2 2 QQPPEPEWIGDGESTSPSDKVVK 23 1 Q5STZ8;Q8NE71;Q8NE71-2;A0A0G2JIC2 Q5STZ8 ABCF1 ATP-binding cassette sub-family F member 1 1 QQPPEPEWIGDGES(0.09)T(0.29)S(0.616)PS(0.004)DKVVK;QQPPEPEWIGDGES(0.141)T(0.141)S(0.576)PS(0.141)DKVVK 106.62 1.1028e-05 70714000.0 423620.0 452600.0 448380.0 496340.0 478980.0 281663.0 281096.0 292021.0 188354.0 489450.0 True False 400076.8962852213 487312.9646616239 419531.7189592321 428737.6357657431 418806.2502644705 320459.52156785794 294167.52098115714 292870.73276332073 226030.06305047858 475318.3067561778 0.8417031084191907 1.0252350009140274 0.8826332017850044 0.9020011004660735 0.881106922059503 0.6741998299094397 0.6188853170598689 0.6161570648562322 0.4755340996500359 1.0 18.85853444215688 -6.75138367286227 3.4735503037704523 0.6448077971828727 0.9164940957302219 0.42265968500371454 0.13232898488268896 0.1967622034459203 5.006058206030908 0.04486885620163505 0.04210474601788551 1.772622784118911e-07 6.75138367286227 0.27168629854734916 QQPPLGPSSS(ph)LLSLPGLK ddPTM_A459_Selumetinib_30min_R1 2 QQPPLGPSSSLLSLPGLK 18 0 Q4KMP7;Q4KMP7-2 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 QQPPLGPS(0.024)S(0.08)S(0.872)LLS(0.024)LPGLK;QQPPLGPS(0.16)S(0.16)S(0.68)LLS(0.001)LPGLK 238.8 6.115500000000001e-25 41322000.0 9227.7 10451.6 12032.4 11251.3 12534.2 9323.4 11874.2 10204.5 5593.5 10371.6 True False 9442.687456021427 9227.921813182984 10398.466169242169 9286.47166805858 11400.483823092745 9229.615060969883 10978.519534026742 9933.84351111251 9491.76096692375 11702.895887939178 0.806867594691064 0.7885160990531529 0.8885378686448596 0.7935191218465059 0.9741592108703545 0.7886607852746755 0.9381028114025207 0.8488363569353954 0.8110608739761422 1.0 13.51457794920569 -14.522878745280336 0.18413260929223932 1.5895801360264006 0.8236161004942208 0.3414788818583586 0.06252292792812218 157.1541868167358 1.5191932843423541 34.24266324258973 0.17724762008895675 3.0000000000000132e-15 14.522878745280336 -0.7659640355321797 QQPPLGPSSS(ph)LLSLPGLK ddPTM_A459_Selumetinib_30min_R2 2 QQPPLGPSSSLLSLPGLK 18 0 Q4KMP7;Q4KMP7-2 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 QQPPLGPS(0.002)S(0.21)S(0.788)LLSLPGLK;QQPPLGPS(0.183)S(0.183)S(0.631)LLS(0.003)LPGLK 197.1 2.4876e-10 32603000.0 170386.0 136806.0 204955.0 235299.0 260429.0 199531.0 205521.0 222559.0 150153.0 167405.0 True False 160916.6282292 147298.58029937776 191768.41843813154 203250.87028658515 227711.58075520038 227014.58408792186 215078.13373213576 223206.6098433741 180187.79562535655 162571.58267957479 0.9898201492345887 0.9060536772266049 1.1795937228224143 1.2502238517735809 1.4006850213423534 1.396397699685085 1.3229749639335817 1.3729743302266406 1.108359730867005 1.0 17.310715572500406 -5.448454401749972 2.643898993018659 1.2936104072818633 0.9444334216353494 0.4862970028549993 0.12522798468253085 0.20550275341330265 2.7802099105641953 0.033864602494692496 0.08299981170677406 3.5607837411305185e-06 5.448454401749972 -0.3491769856465139 QQPPLGPSSSLLS(ph)LPGLK ddPTM_A459_Selumetinib_30min_R1 1 QQPPLGPSSSLLSLPGLK 18 0 Q4KMP7;Q4KMP7-2 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 QQPPLGPSS(0.003)S(0.123)LLS(0.874)LPGLK 242.18 3.3563000000000005e-25 5682000.0 1791.5 1643.3 1955.9 1730.3 1789.0 1270.8 1765.7 1855.9 958.46 1685.7 True False 1833.2384643478206 1450.901672050557 1690.2995229896587 1428.1355867536884 1627.1852658736034 1258.0169057940814 1632.5118274267745 1806.6755031871946 1626.4366168512997 1902.0760151084758 0.9638092535661729 0.7627989946383987 0.8886603424696782 0.7508299223636662 0.8554785681269446 0.6613914984477297 0.858278961755202 0.9498440066729718 0.8550849723839999 1.0 10.893359188288864 -7.535027222433023 10.477281882664244 0.9224360026423758 0.8094442960193744 0.28827510949358115 0.08429587678342008 0.37653983544227454 302.8483675386525 0.037425287131978915 0.02197956076700078 2.9172441496642618e-08 7.535027222433023 -0.1129917066230014 QQQEPTGEPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 QQQEPTGEPSPK 12 0 F5H2U8;F5H2A4;F5H6H0;P52926-3;P52926-6;P52926-4;P52926-5;P52926-2;P52926 F5H2U8 HMGA2 High mobility group protein HMGI-C 1 QQQEPTGEPS(1)PK;QQQEPTGEPS(1)PK 194.67 0.00016356 19271500.0 13989.2 12373.599999999999 12367.5 11839.8 8683.0 11533.7 10457.0 10995.900000000001 8182.8 12531.9 True False 14315.12114175525 10924.89315966942 10688.061429814716 9772.201190571757 7897.624183108162 11417.681449761722 9668.220071021004 10704.25301228302 13885.613951934152 14140.491436043138 1.0123496206975517 0.7725964270112013 0.7558479475877043 0.6910793189028134 0.5585112949453555 0.8074458728258085 0.6837258885060654 0.7569929984893323 0.9819753446857356 1.0 13.787544639726613 -8.265087154654829 5.049771373113485 0.9972275344177257 0.7453969734305937 0.4301030945438641 0.10847446429585271 0.1655229891846328 13.38893392279581 0.09399789865720412 0.02840974865763137 5.431413224061656e-09 8.265087154654829 -0.25183056098713197 QQQEPTGEPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QQQEPTGEPSPK 12 0 F5H2U8;F5H2A4;F5H6H0;P52926-3;P52926-6;P52926-4;P52926-5;P52926-2;P52926 F5H2U8 HMGA2 High mobility group protein HMGI-C 1 QQQEPTGEPS(1)PK;QQQEPT(0.126)GEPS(0.874)PK 140.31 0.0010856 35235000.0 105984.0 93700.0 95570.0 91878.0 84385.0 68849.0 96903.0 91284.0 71943.0 87558.0 True False 100093.83356756727 100886.48870701327 89421.13024874838 79364.0579016094 73783.80188852838 78332.32480100509 101409.18150965175 91549.62132712035 86333.61025537332 85029.97303699523 1.1771594179386367 1.1864814853359897 1.0516424627095038 0.933365671738827 0.8677387426246294 0.9212319139149192 1.1926286447901164 1.0766747072504481 1.0153315021964184 1.0 16.375683859970977 -5.356417161730232 3.7613559699415617 1.002781116150386 1.1832305486830699 0.4128992991205762 0.08475546245660086 0.25216526537205974 6.490870710252359 0.025978452028026996 0.06049087995939055 4.401318915398477e-06 5.356417161730232 0.18044943253268397 QQQLEEEAAKPPEPEKPVS(ph)PPPIESK ddPTM_A459_Selumetinib_30min_R1 1 QQQLEEEAAKPPEPEKPVSPPPIESK 26 2 C9J0Q5;C9JE98;C9J330;H7C1Y3;H0YGK8;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 QQQLEEEAAKPPEPEKPVS(1)PPPIESK 65.67699999999999 0.00062546 13727000.0 2565.3 2302.3 2263.7 2441.3 1778.7 2208.3 2271.9 2430.3 1317.2 2746.7 True False 2625.0664987951236 2032.7456456897692 1956.3019736140348 2014.9727838766578 1617.8168990549907 2186.086506975974 2100.5287538828165 2365.8405492730403 2235.1921955183657 3099.2657001236585 0.8469962735658273 0.6558797606828818 0.6312146691830841 0.6501452211071358 0.5220000656898959 0.7053562741938358 0.6777504599876697 0.7633551873847554 0.7212005719384379 1.0 11.597710727169016 -9.056256262019039 0.7400173001428058 1.0035488923990987 0.6615498905144284 0.5998269155348142 0.07860921654977267 1.239551465261564 1.0840567412644764 0.08987924493982746 0.02874278531309153 8.785039893147881e-10 9.056256262019039 -0.34199900188467036 QQQLEEEAAKPPEPEKPVS(ph)PPPIESK ddPTM_A459_Selumetinib_30min_R2 1 QQQLEEEAAKPPEPEKPVSPPPIESK 26 2 C9J0Q5;C9JE98;C9J330;H7C1Y3;H0YGK8;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 QQQLEEEAAKPPEPEKPVS(0.995)PPPIES(0.005)K 45.941 0.022518 16244000.0 62585.0 51740.0 55347.0 61495.0 57616.0 44673.0 64830.0 59086.0 37555.0 52263.0 True False 59106.776247605296 55708.29162967849 51786.03427725728 53119.27491520802 50377.76298642472 50826.300248882275 67844.72345820793 59257.93047778616 45067.049374373324 50754.03139441836 1.1645730324016297 1.0976131373044975 1.0203334169618772 1.0466020817619186 0.9925864330841113 1.0014239037270223 1.336735656148668 1.1675512043030145 0.8879501418153267 1.0 15.631234799714134 QQQLEEEAAKPPEPEKPVS(ph)PPPVEQK ddPTM_A459_Selumetinib_30min_R1 2 QQQLEEEAAKPPEPEKPVSPPPVEQK 26 2 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 QQQLEEEAAKPPEPEKPVS(1)PPPVEQK;QQQLEEEAAKPPEPEKPVS(1)PPPVEQK 87.74799999999998 2.6453e-05 30888000.0 7447.7 7414.1 7281.200000000001 8060.400000000001 5681.3 7126.599999999999 6393.4 7349.7 5186.8 7681.9 True False 7621.216919298498 6546.053725278419 6292.453032768705 6652.8024524472185 5167.427418114979 7054.912874435078 5911.140690644132 7154.762080809803 8801.620771116503 8667.946693042537 0.8792413231400912 0.7552023515018512 0.7259450543021269 0.7675176934102738 0.5961535760554106 0.8139081981316076 0.6819539736427777 0.8254275590495596 1.0154216543788002 1.0 13.081474565698697 -8.140265406002166 3.327228222036142 1.010350729681842 0.7431834344214154 0.6764682528736035 0.0713135095024505 0.1418184429686786 2.767943708058823 0.0564384411026705 0.018402735058281255 7.2399337808958926e-09 8.140265406002166 -0.2671672952604265 QQQLEEEAAKPPEPEKPVS(ph)PPPVEQK ddPTM_A459_Selumetinib_30min_R2 1 QQQLEEEAAKPPEPEKPVSPPPVEQK 26 2 O75376-2;O75376;A0A088AWL3;O75376-3;E7EVU5;E7EW50;J3KS51 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 QQQLEEEAAKPPEPEKPVS(1)PPPVEQK 50.536 0.012297 34246000.0 55020.0 46329.0 39514.0 42632.0 42742.0 34905.0 50399.0 46481.0 27542.0 37288.0 True False 51962.208662510915 49882.28532878571 36971.712259590284 36825.448055698005 37372.36784167189 39712.84691395777 52742.653363723926 46616.25201465623 33051.16958777766 36211.39855414104 1.4349682900211722 1.3775299303672242 1.0209965297063153 1.016957353929285 1.0320608795541284 1.0966946458746019 1.4565207495332273 1.2873364154924452 0.9127283371384179 1.0 15.144156277108078 -5.168899100192932 5.724282136657119 1.1203843854414277 1.4172510721727187 0.38903566212028984 0.1511300983329874 0.2600514747006931 12.763814106046505 0.041896260803184225 0.11555156631815937 6.77798962617614e-06 5.168899100192932 0.296866686731291 QQQQMEQER ddPTM_A459_Selumetinib_30min_R2 1 QQQQMEQER 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 152.11 0.015813999999999998 2086500.0 4726.6 3060.9 3508.2 4492.0 4569.0 3214.4 3254.8 3631.2 3999.8 5516.0 False True 4463.914494078953 3295.6611876552533 3282.4862314393527 3880.1818508677843 3995.0013726217485 3657.154422582034 3406.1546492638463 3641.766190822477 4799.871763749654 5356.738747710845 0.8333268998766399 0.6152364979650399 0.6127769872745976 0.7243552530027614 0.7457898472888895 0.6827203257102815 0.6358635001043194 0.6798476390842756 0.8960436545091613 1.0 12.387139221083114 -8.40004223147062 3.132188603894048 0.9963415594030273 0.6863466476875631 0.731974003882877 0.06348379508203816 0.11855144803530114 2.148072352077107 0.06105103410845682 0.016396911937695213 3.980684598754676e-09 8.40004223147062 -0.3099949117154641 QQQQQQGEDGS(ph)PQAHR ddPTM_A459_Selumetinib_30min_R2 1 QQQQQQGEDGSPQAHR 16 0 A0A087WUX9;E9PEG3;A0A087WZ66;F5GZG9;P10275-3;P10275-4;P10275 A0A087WUX9 AR Androgen receptor 1 QQQQQQGEDGS(1)PQAHR 109.1 0.0030287 1019600.0 693.18 579.8 554.28 1164.6 900.23 1021.8 0.0 0.0 901.24 906.72 True False 654.6558306193986 624.2687956491603 518.6182282544337 1005.9794709529436 787.1350592416892 1162.5436750231208 0.0 0.0 1081.5131827495723 880.5406376585165 0.7434703210975271 0.7089608008429689 0.5889770512278839 1.1424566089624062 0.8939224671501748 1.3202612409967707 0.0 0.0 1.2282376718301957 1.0 9.782245776903935 -7.257976343719324 24.99987190685121 0.47372609758140377 0.8876573638586106 0.130305545626466 0.4109896961378278 532.5616456395055 3844613.526373919 0.16197097421827816 0.12031564946516243 5.521075120887361e-08 7.257976343719324 0.41393126627720683 QQQQQQQHQQPNR ddPTM_A459_Selumetinib_30min_R2 2 QQQQQQQHQQPNR 13 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;C9JH18 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 0 ; 122.55 0.0036896 666280.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 QQS(ph)EEAFPQEQQK ddPTM_A459_Selumetinib_30min_R2 1 QQSEEAFPQEQQK 13 0 H0YNP1;O94923 H0YNP1 GLCE D-glucuronyl C5-epimerase 1 QQS(1)EEAFPQEQQK 170.49 2.2479e-07 0.0 14500.0 4645.5 9880.7 10010.0 9645.2 8734.4 9428.3 7011.5 6206.1 9672.0 True False 13694.148048099025 5001.794912363184 9244.986519292748 8646.620731786848 8433.483746817972 9937.484317011114 9866.734631822024 7031.90230418369 7447.493412922334 9392.744229126047 1.4579496379380497 0.5325168864763795 0.984268952051828 0.920563843841767 0.8978721810252753 1.0579958396179765 1.0504634631938743 0.7486525910477153 0.7928985641734322 1.0 13.197331008818256 -7.762888989510097 24.999926798100077 0.8280816921390655 0.9653119256008332 0.06909825280891035 0.22132718334532944 108.36546205057887 1868732.0563435329 0.10738895269510904 0.05593957086024739 1.7262790916962128e-08 7.762888989510097 0.13723023346176777 QQS(ph)LPPPK ddPTM_A459_Selumetinib_30min_R2 2 QQSLPPPK 8 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 QQS(1)LPPPK;QQS(1)LPPPK 93.442 0.024057 8988700.0 98965.0 104530.0 94451.0 115066.0 121156.0 59746.0 89269.0 95327.0 64700.0 72888.0 True False 93464.92148828403 112547.11488307493 88374.12549047315 99393.81230007837 105935.3001316175 67975.46917981151 93420.18538316764 95604.38578776557 77641.80786904407 70783.53405423273 1.3204331026573686 1.5900183056252022 1.2485124778138783 1.4041939785589836 1.4966093675183312 0.9603288404296153 1.3198010897787502 1.3506585544953953 1.0968908081017357 1.0 16.111126173457748 -6.738862443113035 24.999997611795422 1.1783434780654831 1.412334823981238 0.45070920477938636 0.14480946926112145 248.5111954950367 275181.95573416527 0.047128501728240235 0.04709604460739282 1.824473488044579e-07 6.738862443113035 0.233991345915755 QQS(ph)PDADRVDSTTLLGNACQDCAK ddPTM_A459_Selumetinib_30min_R2 1 QQSPDADRVDSTTLLGNACQDCAK 24 1 Q9NWS6-2;Q9NWS6 Q9NWS6-2 FAM118A Protein FAM118A 1 QQS(0.611)PDADRVDS(0.248)T(0.07)T(0.07)LLGNACQDCAK 59.048 0.0055878 3567200.0 10479.0 8426.1 11068.0 11204.0 10065.0 5777.8 8338.5 9738.0 6259.6 8210.4 True False 9896.619130760657 9072.3547758182 10355.896929927248 9677.995872021955 8800.544717758354 6573.639504353682 8726.25677242429 9766.335967787318 7511.694907837224 7973.344418818911 1.2412130482413852 1.1378355554797523 1.2988146988213591 1.213793781337186 1.103745712650649 0.8244519688423836 1.0944286756042212 1.2248732093820678 0.9421008943383795 1.0 12.960969274170827 -6.382485081434729 4.1022338796089866 1.0301789331726765 1.2218762572547675 0.46043992959885127 0.10379910786584735 0.23967477346433955 6.845291867030816 0.0344370938306384 0.03926373302482068 4.1449082207787475e-07 6.382485081434729 0.19169732408209095 QQS(ph)PQEPK ddPTM_A459_Selumetinib_30min_R1 1 QQSPQEPK 8 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 QQS(1)PQEPK 107.11 0.01344 29518000.0 10045.0 10823.0 10270.0 9715.9 10154.0 11680.0 9556.8 10563.0 8555.0 9099.3 True False 10279.02895583247 9555.838128523805 8875.390409071928 8019.200455031015 9235.572492834302 11562.509804591486 8835.922881776178 10282.834926540405 14517.210167521715 10267.283789687706 1.001143940927839 0.9307075098208091 0.8644341182023454 0.7810440053371632 0.899514680027678 1.126150795228304 0.8605901095916756 1.0015146300785334 1.4139289869539367 1.0 13.325766946654136 -8.037987863939058 11.07029550282667 1.2075300417911459 0.9233619771953279 0.4374733714969168 0.1269381792449781 0.8436326951009536 242.7001827388866 0.08225731687256095 0.03152945276347511 9.162460936318984e-09 8.037987863939058 -0.284168064595818 QQS(ph)PQEPK ddPTM_A459_Selumetinib_30min_R2 1 QQSPQEPK 8 0 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 QQS(1)PQEPK 89.266 0.029909 20887000.0 145650.0 121550.0 114720.0 134210.0 119720.0 94914.0 154020.0 178200.0 116620.0 182470.0 True False 137555.3560831465 130872.4941551493 107339.04009769176 115930.36647483637 104679.70328962042 107987.54195649314 161182.23518483996 178718.53249740202 139947.2586350531 177201.61698600405 0.7762646776186645 0.738551353995184 0.6057452630704252 0.6542286038168202 0.5907378559524564 0.6094049467111936 0.9095979931016692 1.0085603931679572 0.7897628758438845 1.0 17.435032243155057 -7.280831384840543 11.778393189210833 0.927769299126051 0.6597297421892871 0.7329632555103414 0.07819875843606909 0.5627913320271427 339.68261378926235 0.033172448239510856 0.02271213519985396 5.238037643178449e-08 7.280831384840543 -0.26803955693676385 QQS(ph)SPLVNKEEEHAPELSANQTVNK ddPTM_A459_Selumetinib_30min_R2 1 QQSSPLVNKEEEHAPELSANQTVNK 25 1 Q9BRR8 Q9BRR8 GPATCH1 G patch domain-containing protein 1 1 QQS(0.5)S(0.5)PLVNKEEEHAPELSANQTVNK 67.55199999999999 0.00075464 6079000.0 60831.0 44887.0 59966.0 69583.0 63658.0 56231.0 60742.0 66552.0 54808.0 57305.0 True False 57450.256545786986 48329.68856554652 56107.85284604421 60105.67536262978 55660.71293025943 63976.30983580465 63566.62335798961 66745.65530172335 65771.13146347087 55650.45575372915 1.032341168956864 0.8684509032490347 1.0082191077524898 1.0800571989673613 1.0001843143311473 1.1496098094671503 1.1422480282873513 1.19937302215626 1.181861506301564 1.0 15.76410588222814 -6.269199648802503 0.968374949973164 1.149974967438687 0.9536442028992919 0.4577411358443839 0.07230005359354089 0.44342808544416484 0.8819317452057059 0.03332278863124164 0.05212355465623138 5.380223922672657e-07 6.269199648802503 -0.19633076453939513 QQSFCAKPPPSPLS(ph)PVPSVVK ddPTM_A459_Selumetinib_30min_R2 2 QQSFCAKPPPSPLSPVPSVVK 21 1 C9K0J5;Q70E73 C9K0J5 RAPH1 Ras-associated and pleckstrin homology domains-containing protein 1 1 QQSFCAKPPPSPLS(0.918)PVPS(0.082)VVK;QQSFCAKPPPS(0.389)PLS(0.567)PVPS(0.044)VVK 101.71 0.00012919 12657700.0 115232.0 97866.0 114933.0 136354.0 133708.0 88207.0 112366.0 126959.0 119815.0 137885.0 True False 108827.8667502445 105372.00751121205 107538.33590958854 117782.34997622996 116910.40567531373 100356.7135865771 117591.24164900483 127328.42967080614 143781.34791081195 133903.9017817456 0.8127311101630679 0.786922607251291 0.8031008393233292 0.8796035694927494 0.8730918525874612 0.7494681801741059 0.8781763644249193 0.9508940962627285 1.073765185313016 1.0 17.03083847392773 -7.83241315377505 2.305505161920504 1.0335167461434633 0.8207770077569096 0.8142628336780489 0.041596457734560464 0.12738426160758345 1.3257023994552208 0.03014673764246713 0.012079714663696286 1.4709125255850844e-08 7.83241315377505 -0.2127397383865537 QQSHFAMMHGGT(ph)GFAGIDSSSPEVK ddPTM_A459_Selumetinib_30min_R2 1 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QQSHFAMMHGGT(0.554)GFAGIDS(0.022)S(0.017)S(0.407)PEVK 68.569 0.0024812 14776000.0 37333.0 26979.0 35721.0 48863.0 43474.0 36662.0 35954.0 33842.0 28432.0 34342.0 True False 35258.18131584005 29048.202548842193 33422.74975008414 42207.77510662342 38012.40745750883 41711.85771549978 37625.93224149944 33940.47461715531 34119.19445645537 33350.45722876828 1.0572023368071293 0.8709986297814549 1.0021676620749145 1.2655831018177097 1.1397866960792107 1.2507132189935586 1.128198392705786 1.0176914332640117 1.0230502755153825 1.0 15.02541892018434 -5.540899935717625 24.447110875090164 1.1261235030200032 0.9572211240585543 0.3170240106089738 0.09533198227837575 188.61687601917166 255871.87370597562 0.026733505800856025 0.046315739196675226 2.8780614624876028e-06 5.540899935717625 -0.16890237896144888 QQSHFAMMHGGTGFAGIDS(ph)SSPEVK ddPTM_A459_Selumetinib_30min_R1 2 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QQSHFAMMHGGTGFAGIDS(0.375)S(0.26)S(0.365)PEVK;QQSHFAMMHGGT(0.016)GFAGIDS(0.328)S(0.328)S(0.328)PEVK 133.4 3.4036e-08 101011000.0 2370.3999999999996 2130.4 2675.3 2931.3 2512.2 2312.0 2594.3 2263.4 1147.32 1771.5 True False 2425.625708004508 1880.9717776039101 2312.0089543709987 2419.403482315832 2284.971953564933 2288.74337912804 2398.6098623170865 2203.367279440646 1946.9182430626565 1998.8892808712494 1.2134867754892649 0.941008486865294 1.1566468320662917 1.2103739338985773 1.1431208198630138 1.1450075804751192 1.199971346722922 1.1022958102413114 0.9740000417702273 1.0 10.964982847609182 -8.162196526241427 4.12279563339569 0.9870962890931239 1.1399865025315845 0.41121936087233435 0.07382697455801895 0.23262922426532381 6.671321914512509 0.0572674361720339 0.019453261889418032 6.883407390112127e-09 8.162196526241427 0.15289021343846065 QQSHFAMMHGGTGFAGIDS(ph)SSPEVK ddPTM_A459_Selumetinib_30min_R2 5 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QQSHFAMMHGGTGFAGIDS(0.333)S(0.333)S(0.333)PEVK;QQSHFAMMHGGT(0.004)GFAGIDS(0.44)S(0.321)S(0.235)PEVK;QQSHFAMMHGGT(0.025)GFAGIDS(0.325)S(0.325)S(0.325)PEVK;QQSHFAMMHGGTGFAGIDS(0.333)S(0.333)S(0.333)PEVK;QQSHFAMMHGGT(0.001)GFAGIDS(0.333)S(0.333)S(0.333)PEVK 98.135 2.8842000000000007e-06 35711100.0 149907.0 118945.4 144583.0 171887.0 168821.0 129594.1 144814.0 147358.0 119392.0 137248.0 True False 141575.7690652676 128068.1297102579 135280.6871900681 148475.69407838612 147612.19670111086 147444.5109368896 151548.13794349734 147786.78738357 143273.73609120393 133285.29362687084 1.06220097666293 0.960857167549045 1.0149708456867215 1.1139690661900064 1.1074905016479002 1.106232405126834 1.1370207006314808 1.1088004037211767 1.0749403193145637 1.0 17.024158080204693 -5.731711938448019 7.676954877794756 1.1002156707812298 1.0069532024486256 0.42330273899672743 0.04197816311137239 0.15663272298825034 31.692922120127978 0.010793939792144054 0.018397844101022597 1.854761453247118e-06 5.731711938448019 -0.09326246833260421 QQSHFAMMHGGTGFAGIDSS(ph)SPEVK ddPTM_A459_Selumetinib_30min_R2 1 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QQSHFAMMHGGT(0.001)GFAGIDS(0.104)S(0.448)S(0.448)PEVK 87.729 3.9087e-05 2887600.0 12917.0 7625.2 12589.0 14998.0 13814.0 11075.0 14168.0 11501.0 9291.6 12871.0 True False 12199.124850847938 8210.028321117594 11779.037445866836 12955.246527006906 12078.561821273113 12600.48072115979 14826.840073359399 11534.46600590696 11150.179628995524 12499.380787125854 0.9759783351358353 0.6568348033347204 0.9423696778642859 1.0364710658587653 0.9663328149594277 1.0080883953978 1.1862059669892437 0.9228029933920614 0.8920585602512419 1.0 13.609569005839203 -5.5081247293742175 22.108286647940247 1.0037750708505437 0.8122053630284828 0.3364809252196904 0.10285110197898824 146.75650602014542 219905.8052742397 0.02679299896181498 0.052582584770958014 3.1036680866474268e-06 5.5081247293742175 -0.19156970782206095 QQSHFAMMHGGTGFAGIDSSS(ph)PEVK ddPTM_A459_Selumetinib_30min_R1 3 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QQSHFAMMHGGTGFAGIDS(0.242)S(0.158)S(0.6)PEVK;QQS(0.001)HFAMMHGGTGFAGIDS(0.164)S(0.164)S(0.672)PEVK;QQSHFAMMHGGT(0.002)GFAGIDS(0.175)S(0.128)S(0.695)PEVK 148.35 5.1466e-10 126439000.0 6001.8 5687.4 7263.3 6979.200000000001 6790.3 5504.1 6236.599999999999 6323.9 3222.12 5434.799999999999 True False 6141.630262530143 5021.516563999474 6276.983754451041 5760.413735809595 6176.118563924837 5448.733751322944 5766.168240884533 6156.169629077804 5467.702305666286 6132.409519434982 1.0015036085026512 0.8188488632543474 1.023575437119434 0.9393393767251764 1.0071275482094486 0.8885143325889577 0.940277752588155 1.0038745145064953 0.8916074975648495 1.0 12.582238327374775 QQSHFAMMHGGTGFAGIDSSS(ph)PEVK ddPTM_A459_Selumetinib_30min_R2 3 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 QQSHFAMMHGGTGFAGIDS(0.28)S(0.189)S(0.53)PEVK;QQSHFAMMHGGT(0.002)GFAGIDS(0.38)S(0.094)S(0.525)PEVK;QQSHFAMMHGGT(0.003)GFAGIDS(0.22)S(0.167)S(0.61)PEVK 102.92 1.0868e-06 24213700.0 56013.6 50119.7 60291.0 66436.9 64910.0 55399.1 61056.6 60121.1 48826.3 58333.5 True False 52900.58835220682 53963.7198297641 56411.94269987748 57388.079609954926 56755.425497237375 63029.82316204093 63895.85288135768 60296.04244741612 58592.924320808495 56649.260286365236 0.9338266393028141 0.9525935476822543 0.9958107557753075 1.0130419941911848 1.0018740793848935 1.1126327659606072 1.1279203392658705 1.064374753396888 1.0343104927516782 1.0 15.789769497322336 -5.86805668460549 1.0272566284473932 1.0712017910737563 0.9384568965211618 0.579598336634624 0.03868668645822564 0.42203870322388676 0.8770524273026274 0.0163029198225498 0.04119124660207709 1.355012543043662e-06 5.86805668460549 -0.13274489455259453 QQSSSSKGDS(ph)PELKPR ddPTM_A459_Selumetinib_30min_R2 1 QQSSSSKGDSPELKPR 16 2 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 QQS(0.164)S(0.164)S(0.164)S(0.06)KGDS(0.449)PELKPR 77.357 0.031531 3124900.0 18750.0 16328.0 16140.0 18598.0 14599.0 8852.6 11581.0 13153.0 9397.0 12760.0 True False 17707.95006219701 17580.30509720506 15101.569971903304 16064.920316660522 12764.943103284075 10071.965294098343 12119.539447316143 13191.273052403638 11276.662574117581 12391.585645538491 1.42903019587107 1.4187292571015504 1.2186955248411266 1.2964378229064326 1.0301299178672916 0.8128068176428 0.9780458929144151 1.0645347116777641 0.9100257946550746 1.0 13.597073188221364 -6.200167457784139 2.062456135553664 0.9535521022498663 1.3646441753846938 0.8396678754200164 0.0810380884945654 0.1317083322798942 1.1003851021362767 0.028928179908596204 0.039215228267488536 6.307141031875635e-07 6.200167457784139 0.41109207313482754 QQSSSSRES(ph)PVPK ddPTM_A459_Selumetinib_30min_R1 1 QQSSSSRESPVPK 13 1 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 QQSS(0.002)S(0.071)S(0.02)RES(0.908)PVPK 110.25 0.026853 7993700.0 1729.9 1401.7 1637.5 2121.2 1529.1 1549.8 1081.4 1636.5 957.61 1397.5 True False 1770.2033042005569 1237.588312367349 1415.136494143651 1750.7722398554722 1390.7931749845313 1534.2104191058122 999.8291273598652 1593.0947038988313 1624.994228932844 1576.8827378027497 1.1225966660445423 0.784832177243453 0.8974265874173508 1.110274212459845 0.8819889657251762 0.972938812966906 0.6340542028845093 1.0102810219856118 1.0305105065688862 1.0 10.622859665221421 -7.953197093040456 24.99999619119345 1.0169757892014193 0.9108619050469374 0.10041783644478464 0.13507106910186978 262.7328929300606 140339.5569047315 0.07315030883839371 0.03514024318673136 1.1137889552802704e-08 7.953197093040456 -0.10611388415448186 QQSTPQAANS(ph)PPNLGAK ddPTM_A459_Selumetinib_30min_R2 1 QQSTPQAANSPPNLGAK 17 0 Q9Y4C1;F8WE62 Q9Y4C1 KDM3A Lysine-specific demethylase 3A 1 QQSTPQAANS(1)PPNLGAK 192.72 1.2563999999999999e-20 0.0 4673.9 6187.9 4162.5 5004.5 7064.6 5253.1 7455.4 7228.3 5118.0 4587.8 True False 4414.14334910414 6662.492032765505 3894.6892817873286 4322.878466755971 6177.081789674682 5976.666842106048 7802.090872594837 7249.3331562905205 6141.743008868129 4455.338293464067 0.9907538010255339 1.4953953199332382 0.8741624148946884 0.9702694121112166 1.3864450649541908 1.3414619605594829 1.7511781056088198 1.627111720545489 1.3785132809955196 1.0 12.121319264282134 -6.43273303554017 3.8621735796661696 1.4719184826893505 1.098548888837392 0.2959575546308433 0.24266179761065135 0.2806608414925323 7.675805088176783 0.07867682841037664 0.08833483276951667 3.692044819204815e-07 6.43273303554017 -0.37336959385195856 QQSTS(ph)SDRVSQTPESLDFLK ddPTM_A459_Selumetinib_30min_R1 1 QQSTSSDRVSQTPESLDFLK 20 1 Q12965 Q12965 MYO1E Unconventional myosin-Ie 1 QQS(0.119)T(0.132)S(0.374)S(0.374)DRVS(0.001)QTPESLDFLK 82.755 0.0017493 7081000.0 1594.3 1820.2 1423.0 1854.4 1741.9 1524.1 1352.9 1389.3 928.15 1385.2 True False 1631.4440880322259 1607.0901378119772 1229.76441597949 1530.5638513992028 1584.345452557424 1508.7689377720794 1250.849663773962 1352.4512509175975 1575.002760606111 1563.0039129906045 1.043787590339854 1.0282060873008434 0.7867954812899322 0.979245054141079 1.0136541817902331 0.9653008064997397 0.8002856892281377 0.8652897409129694 1.0076767866771033 1.0 10.610105674800735 -7.069433193781016 24.999946094386942 0.9036165880697232 0.966415136668313 0.06538729114766617 0.08759479560859793 423.2186361797098 152380.92469756355 0.03449641519241819 0.026720818766920455 8.522496002990963e-08 7.069433193781016 0.0627985485985898 QQSTS(ph)SDRVSQTPESLDFLK ddPTM_A459_Selumetinib_30min_R2 2 QQSTSSDRVSQTPESLDFLK 20 1 Q12965 Q12965 MYO1E Unconventional myosin-Ie 1 QQS(0.118)T(0.118)S(0.311)S(0.311)DRVS(0.141)QT(0.001)PESLDFLK;QQS(0.215)T(0.215)S(0.257)S(0.257)DRVS(0.056)QTPESLDFLK 78.531 0.0026691 11286600.0 19254.9 17722.8 19593.2 24622.0 20089.9 21700.0 25401.0 21423.0 20616.8 20442.1 True False 18184.789741471854 19082.081772216174 18332.59484346319 21268.441124680896 17566.027156015258 24688.978027012858 26582.196831126625 21485.337383231436 24740.736081522562 19851.883458045653 0.9160233979764699 0.961222738010912 0.9234687923796611 1.0713563360186429 0.8848544367661006 1.24365922655096 1.3390264398491258 1.0822820629910443 1.2462664378324029 1.0 14.276988269873732 -6.765174902895692 24.999966927808863 1.1971882125086855 0.9570458224971323 0.574152262752504 0.09893390593733628 66.74148054226207 446663.535785024 0.03296400992827099 0.030182719096967774 1.7172166752692312e-07 6.765174902895692 -0.24014239001155313 QQTEKPES(ph)EDEWER ddPTM_A459_Selumetinib_30min_R1 4 QQTEKPESEDEWER 14 1 A2AB15;A0A140T947;O60231 A2AB15 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 1 QQTEKPES(1)EDEWER;QQT(0.053)EKPES(0.947)EDEWER;QQTEKPES(1)EDEWER;QQT(0.013)EKPES(0.987)EDEWER 222.09 2.5846e-08 139922400.0 9643.33 9830.0 9743.300000000001 10497.6 10561.9 9192.6 10753.8 10128.199999999999 6382.69 9705.1 True False 9868.00082634623 8679.099030156978 8420.213376115933 8664.391224357345 9606.578009854893 9100.130790212988 9942.632208065954 9859.56723496984 10830.958756766706 10950.844120679409 0.9011178241238633 0.7925506869162258 0.7689099838628265 0.7912076118402269 0.8772454345975007 0.830998112102467 0.9079329500536344 0.9003476924989903 0.9890524088744618 1.0 13.418754460497441 -7.766065203304496 0.7979774266282151 1.0040171182911242 0.8136371840830807 0.7329498368892112 0.03937249290499122 0.3239125499379368 0.3877678316714972 0.036540522803180826 0.0165064870555797 1.7136999998611792e-08 7.766065203304496 -0.19037993420804344 QQTEKPES(ph)EDEWER ddPTM_A459_Selumetinib_30min_R2 3 QQTEKPESEDEWER 14 1 A2AB15;A0A140T947;O60231 A2AB15 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 1 QQTEKPES(1)EDEWER;QQT(0.001)EKPES(0.999)EDEWER;QQTEKPES(1)EDEWER 131.61 0.0041571 252655600.0 686870.0 513935.0 616222.0 574931.0 640762.0 547848.0 637799.0 619576.0 409747.0 502855.0 True False 648696.5151584666 553352.1619385147 576574.9474117856 496624.4059887056 560263.7490750395 623309.0891310106 667457.9172747425 621378.8635836709 491707.8492877461 488336.26957580436 1.3283807809769281 1.1331375456080433 1.1806924517661368 1.0169721909455973 1.1472908812644929 1.2763931904391435 1.366799803452103 1.272440533903891 1.0069042172822233 1.0 18.89751540783699 -8.273498691382917 24.020786996537392 1.0034519938652522 1.2095869385490658 0.42970491852231985 0.0974299707781711 546.8740047687043 1089292.364865337 0.10087219944181317 0.02695544511262461 5.327228295221388e-09 8.273498691382917 0.20613494468381366 QQTQQVQSPVDSATMS(ph)PVER ddPTM_A459_Selumetinib_30min_R2 1 QQTQQVQSPVDSATMSPVER 20 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 QQTQQVQSPVDS(0.002)AT(0.002)MS(0.996)PVER 137.87 9.001899999999999e-05 5160900.0 11581.0 12831.0 10828.0 16012.0 13301.0 11952.0 11440.0 14640.0 12066.0 17452.0 True False 10937.374382416183 13815.096441832324 10131.338268635003 13831.137977759345 11630.0094675513 13598.279510546443 11971.982667929957 14682.599976217527 14479.537152208444 16948.115414258446 0.6453445775578429 0.8151405689749839 0.5977855366804684 0.8160870775120643 0.6862125483147805 0.8023475872194151 0.7063902018190135 0.8663264095938985 0.8543449698263686 1.0 14.048837237945632 -8.385999348627513 0.5954334254855767 1.0041470133630248 0.7106314456490606 0.6107692719073254 0.07112125536955165 0.5123603484593025 0.435668493721538 0.06696336672108973 0.030504917254600823 4.111503377640206e-09 8.385999348627513 -0.29351556771396425 QQTS(ph)TPVLTQPGR ddPTM_A459_Selumetinib_30min_R1 1 QQTSTPVLTQPGR 13 0 Q5T5U3;A0A087WW76;A0A452Q6Z5;E7ESW5;A0A1B0GV73;Q5T5U3-3 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 QQT(0.018)S(0.751)T(0.23)PVLT(0.002)QPGR 109.95 0.0057582 3556800.0 1153.7 1388.8 1343.9 1161.3 1488.5 1329.8 1394.8 1200.5 753.3 1179.1 True False 1180.5789652905844 1226.1986503643961 1161.4057615142906 958.5007553008489 1353.8654378160195 1316.4234193617942 1289.5891130400776 1168.6588402264274 1278.2950811448404 1330.4489704065988 0.8873538117961693 0.9216427519122791 0.8729427338797918 0.7204340614491372 1.0176004250672346 0.9894580315692091 0.9692886700088662 0.8783943362136417 0.9607997823127183 1.0 10.37769746127312 -6.297772007324181 24.999993480955 0.9641882371438029 0.8572645439344687 0.4804168142173497 0.06015839793279025 598.2212487454591 411626.4425156084 0.019737660586971524 0.0223810943701073 5.037650021732668e-07 6.297772007324181 -0.10692369320933415 QQVAFYGQTLGQAQAHS(ph)QEQ ddPTM_A459_Selumetinib_30min_R1 2 QQVAFYGQTLGQAQAHSQEQ 20 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 1 QQVAFYGQTLGQAQAHS(1)QEQ;QQVAFYGQTLGQAQAHS(1)QEQ 186.36 1.2382999999999998e-15 10337200.0 3599.5 3930.0 4952.1 4761.7 5155.9 4425.4 4558.0 4816.5 3108.2 4345.700000000001 True False 3683.361346592229 3469.873772992565 4279.63201993818 3930.158483179237 4689.549755348076 4380.884493941709 4214.186390333146 4688.750773803073 5274.3883860538845 4903.512925702619 0.7511678672825042 0.7076301879015381 0.8727685813788195 0.8014985465988322 0.9563653295919712 0.8934175478519772 0.8594218989907729 0.956202388949801 1.0756346451963563 1.0 12.25959996545008 -4.968934184678734 0.27295418218844136 1.031799278968169 0.4940832631196381 0.7239358334608916 0.0568058184998483 4.3416975080997755 0.2939569160769708 0.07609906947458649 0.7811953343333875 1.074152182805562e-05 4.968934184678734 -0.5377160158485308 QQVAFYGQTLGQAQAHS(ph)QEQ ddPTM_A459_Selumetinib_30min_R2 4 QQVAFYGQTLGQAQAHSQEQ 20 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 1 QQVAFYGQTLGQAQAHS(1)QEQ;QQVAFYGQTLGQAQAHS(1)QEQ;QQVAFYGQTLGQAQAHS(1)QEQ;QQVAFYGQTLGQAQAHS(1)QEQ 212.26 5.0963e-17 26731300.0 95828.0 82434.0 103948.0 104535.0 106447.0 90083.0 88189.0 87977.0 82646.0 90441.0 True False 90502.26338987803 88756.42273291296 97260.0988500252 90297.15266706658 93074.17621174593 102491.11555794468 92289.96324318838 88232.99850462361 99177.50932217982 87829.73333606166 1.0304285343050117 1.0105509758671989 1.1073709910729237 1.0280932121422237 1.0597114744231038 1.1669295996355173 1.0507826875673254 1.00459144247904 1.1292019861053013 1.0 16.422421803077384 -3.4780373577468318 13.400623445617072 1.06086147482993 1.0267173964717753 0.0 0.05439523601347615 0.0 0.0 0.012239204719529596 0.0 0.0003326309393525268 3.4780373577468318 -0.034144078358154806 QQVEQSSAS(ph)QTGIK ddPTM_A459_Selumetinib_30min_R1 2 QQVEQSSASQTGIK 14 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 QQVEQS(0.029)S(0.012)AS(0.957)QT(0.002)GIK;QQVEQS(0.336)S(0.16)AS(0.486)QT(0.018)GIK 192.78 0.00011263 5267900.0 1351.23 1909.52 1846.09 2298.46 1628.75 2035.25 1972.1100000000001 1919.0 915.6800000000001 1500.05 True False 1382.7110299641113 1685.9525106882356 1595.4011178465055 1897.0771084377752 1481.4298500791674 2014.777232859145 1823.3521549451311 1868.101886209508 1553.8420813788764 1692.5960292243408 0.8169173305917306 0.9960749532544102 0.9425764271570598 1.1208091450546183 0.8752412415607854 1.1903473705905177 1.0772518211452449 1.1036903395464042 0.9180229981343803 1.0 10.72502197190733 -3.836554297607007 0.8528332277733113 1.0461653021003272 2.924257173303589e-17 0.31617864610395596 0.09300576169834013 11.48185319814607 1.9529964494765826 0.031139824337069723 16.491835410289347 0.00014569535379301633 3.836554297607007 -1.0461653021003272 QQVSWEQEFLVGS(ph)SPGGSGR ddPTM_A459_Selumetinib_30min_R1 1 QQVSWEQEFLVGSSPGGSGR 20 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 1 QQVSWEQEFLVGS(0.5)S(0.5)PGGSGR 306.18 2.055699999999999e-101 13956000.0 1587.0 1911.6 1746.1 1512.1 2099.3 1574.4 1421.6 1377.6 1120.1 1590.1 True False 1623.9740122355527 1687.7889833212696 1508.9892106407492 1248.0401206324061 1909.4186856615183 1558.5629654408258 1314.3675674632743 1341.0615729245533 1900.7278911327962 1794.2048238856196 0.9051218626859967 0.9406891347366403 0.841035087272147 0.6955951204777101 1.0642144420983028 0.8686650178910589 0.7325627208028648 0.7474406238749728 1.0593706280515314 1.0 10.80912888034655 -8.276822061576228 24.80718902748631 1.0296853577835101 0.8509577839101623 0.3259008975623764 0.10368658097777164 1048.0030956810617 1690064.8022486747 0.10214243325129187 0.026789135962245227 5.286618098590524e-09 8.276822061576228 -0.1787275738733478 QQVSWEQEFLVGSS(ph)PGGSGR ddPTM_A459_Selumetinib_30min_R2 1 QQVSWEQEFLVGSSPGGSGR 20 0 Q9BUA3 Q9BUA3 C11orf84 Uncharacterized protein C11orf84 1 QQVSWEQEFLVGS(0.043)S(0.957)PGGSGR 176.39 4.478e-13 3711000.0 18922.0 16522.0 14482.0 14937.0 22877.0 14508.0 16843.0 18690.0 12633.0 13628.0 True False 17870.390990767566 17789.18427339674 13550.243886809398 12902.554832237778 20002.986737025116 16506.3453094886 17626.232873771343 18744.384805703932 15159.95299551212 13234.524230203657 1.3502858644501927 1.3441498888791557 1.0238557617269846 0.9749164086149571 1.5114246941627538 1.2472186398524274 1.3318372891369217 1.4163247941263915 1.1454853028198986 1.0 13.69201871166548 -8.526029264277902 22.99724021881789 0.9999999875676574 1.2686016598093066 0.236975133579309 0.15613217299583582 168.99346083048763 1233579.9239935023 0.15906151162375212 0.04106950571932759 2.9783157333588665e-09 8.526029264277902 0.2686016722416492 QQYES(ph)VAAK ddPTM_A459_Selumetinib_30min_R2 2 QQYESVAAK 9 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QQYES(1)VAAK;QQYES(1)VAAK 110.8 0.010641 11919600.0 55913.0 57079.0 65075.0 62525.0 59408.0 44512.0 42514.0 43185.0 49195.0 62855.0 True False 52805.579297473145 61456.775762087665 60888.145348302845 54008.98713835887 51944.635925741466 50643.12396029477 44490.98523989282 43310.66120033839 59035.37462314726 61040.212833097365 0.8650949406395383 1.0068244016469816 0.9975087327232899 0.8848099413748111 0.850990412955702 0.8296682073958126 0.7288799166140655 0.7095430895492288 0.9671554518423462 1.0 15.897472372074429 -6.066156115868536 2.5455374724688684 0.8251610808468373 0.9606847616020091 0.18688893617045776 0.09337899762645313 0.37331996862409705 4.777409691797459 0.029075933095301435 0.0420052725547726 8.587047873469227e-07 6.066156115868536 0.13552368075517185 QQYESVAAK ddPTM_A459_Selumetinib_30min_R1 1 QQYESVAAK 9 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 148.94 0.020481 8838000.0 2937.9 2857.5 3361.5 3522.3 3438.4 3127.9 2813.7 3404.6 1955.2 2620.4 False True 3006.3473538417343 2522.9425715842913 2905.0267633977905 2907.196426759821 3127.397327098824 3096.4361659059705 2601.460343677133 3314.298948300618 3317.831597842017 2956.7538648574787 1.0167729514362691 0.8532812289757172 0.9825054421761341 0.9832392412886737 1.057713110404464 1.0472417750793148 0.8798366257661182 1.1209248722704803 1.1221196452217854 1.0 11.529798435888614 -5.849163878290327 2.0927033363468017 1.0359534926940905 0.9352950202053846 0.21720828800410297 0.0748272916112677 0.4800164475695979 4.288354275644904 0.023666032115846294 0.0423056568494401 1.415259639865403e-06 5.849163878290327 -0.10065847248870596 QQYESVAAK ddPTM_A459_Selumetinib_30min_R2 2 QQYESVAAK 9 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ; 153.05 0.014438 12046800.0 53275.0 47708.0 51297.0 57596.0 50017.0 46294.0 44135.0 48816.0 44305.0 45219.0 False True 50314.18877672244 51367.05019460187 47996.606867950635 49751.325441358145 43733.41730234669 52670.57828490937 46187.3649518434 48958.04647807615 53167.237985131396 43913.40997692834 1.1457590927955037 1.1697349447831447 1.0929829155414614 1.1329415198568498 0.9959011911241641 1.1994190000863507 1.051782700913224 1.114876902153538 1.2107289780744634 1.0 15.422373946940155 -11.064689514666263 2.757491861251163 0.9934284028928355 1.1205888504691321 0.2618607205526984 0.0621425120751489 13935182.123548169 13754025.569353163 676948.3641038978 0.014851671679057724 8.616095129750158e-12 11.064689514666263 0.12716044757629663 QREMEEEEDEDEDEDEDEDER ddPTM_A459_Selumetinib_30min_R2 2 QREMEEEEDEDEDEDEDEDER 21 1 B4E321;Q13438-8;Q13438-6;Q13438-5;Q13438-3;Q13438-2;Q13438-7;Q13438-4;Q13438 B4E321 OS9 Protein OS-9 0 ; 293.22 9.990699999999993e-156 4384000.0 16014.3 9909.9 15144.9 20438.5 20888.9 12102.2 16697.8 17365.1 13337.7 12886.7 False True 15124.289316322207 10669.957464649224 14170.493622520344 17654.741041620924 18264.64963286462 13769.168197166597 17474.280786063006 17415.62956605294 16005.61268647526 12514.627487332362 1.2085289259813299 0.8525988868186158 1.1323144565720469 1.4107284503267494 1.4594641072099497 1.1002459490787173 1.3963085040885905 1.3916218907579552 1.278952386131874 1.0 13.611327727693018 -5.562848572197555 6.0415685479281045 1.3093748437387582 1.0208290265220705 0.3082320551764741 0.1585054075800728 0.17420571465233955 16.49471432802199 0.0410919345934263 0.07320614099584556 2.736222613514375e-06 5.562848572197555 -0.2885458172166877 QREMEEQMR ddPTM_A459_Selumetinib_30min_R1 4 QREMEEQMR 9 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 ;;; 140.14 0.0062164 46340000.0 6039.8 5181.299999999999 8686.2 9038.8 8126.400000000001 6301.1 6384.1 6358.200000000001 4674.9 5212.710000000001 False True 6180.515588595013 4574.670987278976 7506.661749881267 7460.343259289855 7391.368554832453 6237.716654941048 5902.542197131601 6189.559881655699 7932.963858813237 5881.812104595189 1.050784261497653 0.7777655773303258 1.2762498387217533 1.2683749712884287 1.2566481933446865 1.0605093369214917 1.003524439776003 1.0523219326948716 1.3487278610303748 1.0 12.522044982505143 -5.264124926133039 24.99990914196273 1.158587449605007 0.9142749197474835 0.3473094670915723 0.13380689549977745 246.93577876129334 2298763.809769856 0.03577362893302482 0.0802708340166894 5.4434604751777265e-06 5.264124926133039 -0.2443125298575235 QRESVGGS(ph)PQTK ddPTM_A459_Selumetinib_30min_R1 1 QRESVGGSPQTK 12 1 Q08495;Q08495-2;E5RGQ0;Q08495-3;Q08495-4;E5RFK4;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 QRESVGGS(1)PQTK 83.292 0.019088 2616600.0 1123.7 1035.9 1699.5 2165.7 1923.9 1263.0 1655.3 1577.4 884.32 1160.8 True False 1149.8800236604218 914.6163464231554 1468.717234685272 1787.5011502239286 1749.8835846921331 1250.2953667122479 1530.439388310325 1535.5622278826881 1500.6264518226537 1309.7999871495047 0.8779050503450424 0.6982870326740644 1.12132940074432 1.3647130613537697 1.335992977447171 0.9545696892494588 1.1684527434154235 1.172363905136773 1.1456913013783436 1.0 10.355130806670251 -5.331511448752081 5.797741996160222 1.1732506167269454 0.7893345120236138 0.5778764707988886 0.12623418994036303 0.13755456272720287 8.55748086270433 0.0341351488512578 0.07322144919853811 4.661101403721785e-06 5.331511448752081 -0.3839161047033316 QRHS(ph)YPER ddPTM_A459_Selumetinib_30min_R2 1 QRHSYPER 8 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 QRHS(1)YPER 75.652 0.031734 3717000.0 11848.0 8311.0 7250.6 8947.5 8987.2 7571.0 11010.0 15572.0 10964.0 13526.0 True False 11189.53559130187 8948.426975923034 6784.10428985639 7728.835064701582 7858.147589412599 8613.836527304808 11521.986815901113 15617.311941916618 13157.106359755788 13135.469235231487 0.8518565565430809 0.681241516056532 0.5164721692362773 0.5883942877329099 0.5982388180192113 0.6557692285709202 0.8771659854371439 1.1889420668755724 1.0016472288988556 1.0 13.681180117992051 -7.443053821771679 3.0454566651129436 1.0703902959516969 0.6385020359002346 0.7879952453954115 0.09671401870098019 0.11593463769130305 2.087252257856753 0.048901296230194985 0.029490132287560103 3.6053395956442746e-08 7.443053821771679 -0.4318882600514623 QRPVPQPSSAS(ph)LDEYTLMR ddPTM_A459_Selumetinib_30min_R1 3 QRPVPQPSSASLDEYTLMR 19 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 QRPVPQPS(0.159)S(0.159)AS(0.681)LDEYT(0.001)LMR;QRPVPQPS(0.001)S(0.031)AS(0.952)LDEYT(0.016)LMR;QRPVPQPS(0.009)S(0.055)AS(0.667)LDEYT(0.269)LMR 214.81 1.4379e-16 45390500.0 4153.35 3810.62 4522.33 4382.15 4649.370000000001 3737.4700000000003 5057.26 4820.49 2255.41 3630.84 True False 4250.114973987734 3364.4708388908252 3908.2224253805507 3616.889765643341 4228.8353044129435 3699.8744451512466 4675.786806576615 4692.634946041724 3827.2660413711474 4096.893681376557 1.0373993821972198 0.8212248353392375 0.9539477295069535 0.8828371070708542 1.032205283636273 0.9030926191641098 1.1413004998961922 1.145412917931763 0.9341872987256007 1.0 12.00031473853936 -7.250054863358187 24.864797731816914 1.067342924228658 0.9355607162361786 0.31192385648587917 0.08413451364100916 738.8459305737559 1613708.469351182 0.031345102535012534 0.024051698413950537 5.622702904749881e-08 7.250054863358187 -0.13178220799247942 QRPVPQPSSAS(ph)LDEYTLMR ddPTM_A459_Selumetinib_30min_R2 3 QRPVPQPSSASLDEYTLMR 19 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 QRPVPQPSS(0.078)AS(0.851)LDEY(0.065)T(0.005)LMR;QRPVPQPS(0.102)S(0.102)AS(0.604)LDEY(0.185)T(0.009)LMR;QRPVPQPS(0.001)S(0.004)AS(0.811)LDEY(0.001)T(0.183)LMR 195.48 1.6127e-14 19465100.0 38103.4 27690.8 38480.8 44441.2 40293.0 28843.399999999998 33194.4 36104.3 32917.1 31669.1 True False 35985.76556799559 29814.595320044456 36004.98722272718 38388.231894653894 35231.03311600964 32816.316535683996 34738.005373455744 36209.357535611365 39501.439780619956 30754.730796796506 1.1700887842511685 0.9694311914819305 1.170713782559838 1.2482057524188284 1.1455484149345698 1.0670331258143293 1.1295174587278178 1.177358949257427 1.2844020661931637 1.0 14.908520727306078 QRPVPQPSSASLDEYT(ph)LMR ddPTM_A459_Selumetinib_30min_R1 1 QRPVPQPSSASLDEYTLMR 19 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 QRPVPQPSS(0.086)AS(0.297)LDEY(0.001)T(0.616)LMR 95.591 0.0023703 17098000.0 1697.8 1860.0 2317.8 1917.4 1929.5 1817.7 1852.4 1986.8 1141.2 1475.8 True False 1737.355436656283 1642.23033530946 2003.0554907640635 1582.5620840556683 1754.977065680894 1799.41558833955 1712.671976624205 1934.1036099640692 1936.5330500497714 1665.233305509337 1.0433105264639697 0.9861863379000572 1.2028677808311061 0.9503545712302562 1.0538926046426313 1.0805786686984207 1.028487702568715 1.1614610418643374 1.162919960610236 1.0 10.70150860317277 -7.752517785502467 24.983381373245063 1.1216428802070828 1.0504197870213996 0.10519268525161507 0.07544457160603321 335.43273390591213 939328.7129463016 0.03463266309598611 0.01961257433011523 1.767999812004545e-08 7.752517785502467 -0.0712230931856832 QRS(ph)DDESPSTSSGSSDADQR ddPTM_A459_Selumetinib_30min_R2 1 QRSDDESPSTSSGSSDADQR 20 1 R4GMM6;R4GN77;R4GNG6;R4GND1;A0A1B0GX65;Q969T4 R4GMM6 UBE2E3 Ubiquitin-conjugating enzyme E2 E3 1 QRS(0.999)DDES(0.001)PSTSSGSSDADQR 133.15 0.00052382 0.0 1259.4 1287.4 1162.8 1104.0 3137.2 637.28 2316.0 2455.0 575.47 2288.9 True False 1189.407589777649 1386.1394403565528 1087.9867139609144 953.6332954937735 2743.0768890761556 725.0595353481457 2423.698589066936 2462.143643552872 690.5800799752526 2222.813509723595 0.5350910387104634 0.6235968219074384 0.4894637850640941 0.42902082937779024 1.2340562431696103 0.3261899984755384 1.090374238983423 1.1076699114803552 0.31067837088192146 1.0 11.11817119844175 -6.190373770547087 24.999776632169084 0.8365670089653249 0.5246124236241129 0.22386713299576633 0.2966392441350586 250.18270528387657 88009.51164014263 0.08421870436868645 0.1087258720350943 6.450987932029792e-07 6.190373770547087 -0.311954585341212 QRS(ph)DDESPSTSSGSSDADQRDPAAPEPEEQEER ddPTM_A459_Selumetinib_30min_R1 1 QRSDDESPSTSSGSSDADQRDPAAPEPEEQEER 33 2 R4GMM6;R4GN77;R4GNG6;R4GND1;A0A1B0GX65;Q969T4 R4GMM6 UBE2E3 Ubiquitin-conjugating enzyme E2 E3 1 QRS(0.999)DDES(0.001)PSTSSGSSDADQRDPAAPEPEEQEER 84.398 1.2807e-08 20595000.0 302.17 347.09 485.06 508.34 443.83 343.28 550.78 403.4 256.47 357.73 True False 309.2099730795318 306.4525414422366 419.1915162438589 419.567961723614 403.685654864551 339.82691487330163 509.23422116447796 392.70052157212876 435.2108581723315 403.6481300852795 0.7660384132442393 0.7592071376064391 1.0385072666019672 1.039439874612998 1.000092964085486 0.8418889858389924 1.2615795372491658 0.9728783371030659 1.078193668531014 1.0 8.656954398152168 -5.260650257803386 24.930378989114143 1.0290579192433738 0.7626227476015196 0.5404920652037859 0.09827142079076805 47.281432527897834 1493671.1104970844 0.024903565038515155 0.058508010577192356 5.48718676317723e-06 5.260650257803386 -0.26643517164185415 QRS(ph)DDESPSTSSGSSDADQRDPAAPEPEEQEER ddPTM_A459_Selumetinib_30min_R2 1 QRSDDESPSTSSGSSDADQRDPAAPEPEEQEER 33 2 R4GMM6;R4GN77;R4GNG6;R4GND1;A0A1B0GX65;Q969T4 R4GMM6 UBE2E3 Ubiquitin-conjugating enzyme E2 E3 1 QRS(0.945)DDES(0.053)PS(0.001)TSSGSSDADQRDPAAPEPEEQEER 62.032 0.00017429 34852000.0 5908.5 5399.3 8449.3 7929.7 8202.8 5380.6 5598.1 7279.5 3690.2 8213.2 True False 5580.129223599518 5813.4089485141685 7905.681236902261 6849.661180504512 7172.290930037574 6121.728809776284 5858.422742424709 7300.682139813899 4428.343112802884 7976.06357554364 0.6996094214581511 0.7288568970713016 0.9911758052108328 0.8587771543731266 0.8992269008523692 0.7675125394620533 0.7345005072913308 0.9153239653454358 0.5552040891927135 1.0 12.961461193866098 -9.439866929947815 14.028542849738866 0.9999961420471037 0.804292223834657 0.20491066092518706 0.12006341096243543 0.0 0.0 0.1147634921768497 0.027834235306464557 3.6318932078986095e-10 9.439866929947815 -0.1957039182124467 QRS(ph)PAPGS(ph)PDEEGGAEAPAAGIR ddPTM_A459_Selumetinib_30min_R2 2 QRSPAPGSPDEEGGAEAPAAGIR 23 1 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 2 QRS(1)PAPGS(1)PDEEGGAEAPAAGIR;QRS(1)PAPGS(1)PDEEGGAEAPAAGIR 133.91 1.2483e-05 28924000.0 53762.0 54181.0 55510.0 65718.0 64170.0 48141.0 41855.0 41297.0 47159.0 51882.0 True False 50774.12326633792 58336.508480626355 51938.54703471823 56767.09503012662 56108.390912921335 54771.98576951275 43801.34043410911 41417.16743291362 56592.11773255411 50384.03185437528 1.0077423619667858 1.1578372419507053 1.0308533303733205 1.126688217294723 1.1136145490517937 1.0870901703107039 0.8693496495220531 0.8220296373387 1.1232153452133808 1.0 15.62067895425304 -7.241482626508412 22.870173717111545 0.9388178148186446 1.090930542690535 0.3646656926113354 0.08545466212531373 255.9784534828193 293347.8959768177 0.031667120791131854 0.02448118903157579 5.734788075004774e-08 7.241482626508412 0.15211272787189034 QRS(ph)PAPGSPDEEGGAEAPAAGIR ddPTM_A459_Selumetinib_30min_R1 2 QRSPAPGSPDEEGGAEAPAAGIR 23 1 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 QRS(1)PAPGSPDEEGGAEAPAAGIR;QRS(1)PAPGSPDEEGGAEAPAAGIR 194.89 7.8414e-23 56446000.0 3596.6 3159.1 3897.7 4432.9 3873.2 3411.3999999999996 4145.799999999999 3537.1 2151.88 2927.8 True False 3680.3937822346497 2789.2311033742544 3368.4137485335596 3658.777230838829 3522.869743868998 3377.0844133033747 3833.07896819727 3443.284617879962 3651.58319290317 3303.6116491870407 1.1140515814382506 0.8442975142252673 1.0196155317960771 1.1075082725716832 1.0663692098119077 1.0222401335018947 1.1602692371969694 1.0422788703773012 1.1053306443575954 1.0 11.689828387665928 -5.523766901065793 21.778417289758682 1.074241248635269 0.9673701014762006 0.20159211150967338 0.07445523494970965 6.778953998498489 166225.72478549925 0.018688481328336108 0.032873980302832194 2.9938711062806494e-06 5.523766901065793 -0.10687114715906842 QRS(ph)PAPGSPDEEGGAEAPAAGIR ddPTM_A459_Selumetinib_30min_R2 3 QRSPAPGSPDEEGGAEAPAAGIR 23 1 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 QRS(1)PAPGSPDEEGGAEAPAAGIR;QRS(1)PAPGSPDEEGGAEAPAAGIR;QRS(0.998)PAPGS(0.002)PDEEGGAEAPAAGIR 195.86 6.192899999999998e-23 59618000.0 50525.2 45184.399999999994 46670.899999999994 45577.1 56960.5 33241.1 38110.7 37384.0 38646.2 51042.6 True False 47717.21165240089 48649.89818925478 43668.1451054338 39369.42035511713 49804.61275666909 37819.75979233814 39882.92306491939 37492.781250745626 46376.51986504874 49568.867513398356 0.9626447818180036 0.981460756110775 0.8809591038897631 0.7942368331186034 1.0047559134411739 0.7629740538678949 0.8045962126154915 0.7563776041607448 0.9355977288065592 1.0 15.597146677868123 -6.7679824138244085 24.99971130681521 0.8337256789554546 0.9182682702618203 0.12480410964778821 0.08948775666323883 284.01625902552183 1085166.4679221474 0.030854739297898188 0.027840537353665335 1.7061514759319247e-07 6.7679824138244085 0.08454259130636577 QRS(ph)PIALPVK ddPTM_A459_Selumetinib_30min_R1 1 QRSPIALPVK 10 1 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 QRS(1)PIALPVK 85.973 0.01964 43961000.0 8961.1 8961.3 7207.6 7570.3 8307.3 7751.8 9032.1 8529.8 5110.4 7682.9 True False 9169.876194734723 7912.10683000465 6228.847508512838 6248.289217130809 7555.906181772938 7673.823930071256 8350.801425214571 8303.561995304766 8671.975551151729 8669.075052783359 1.0577686937651525 0.9126817776787305 0.7185135058339306 0.7207561566934049 0.8715931210385567 0.8851952351718815 0.9632863222857206 0.9578371331136142 1.0003345799120102 1.0 13.081662357930671 -7.195518747943116 1.8895101049453138 0.9843928607164835 0.8444738433842659 0.29546082207178703 0.09109645957586016 0.4893190835844622 3.4216265569003976 0.05063057898001211 0.03354501931783986 6.37501560305393e-08 7.195518747943116 -0.13991901733221757 QRS(ph)PIALPVK ddPTM_A459_Selumetinib_30min_R2 1 QRSPIALPVK 10 1 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 QRS(1)PIALPVK 130.19 0.0015518 109310000.0 219960.0 197340.0 231640.0 236610.0 261800.0 195310.0 208270.0 222000.0 182830.0 198220.0 True False 207735.5037696455 212475.3434518892 216736.53459056217 204383.3098249835 228910.34347830445 222212.17965234478 217954.9676791759 222645.98324592144 219401.10869702176 192496.87356258914 1.079163001066101 1.1037859447769378 1.1259223621628933 1.061748723719035 1.1891639549349653 1.1543677335626643 1.1322519875020682 1.156621295324724 1.1397645303869566 1.0 17.55447548890733 -6.246466565275749 24.960304782482407 1.13798747976828 1.0958263187923962 0.09380965180330891 0.049718447729071975 1566.1930014346535 2610906.5189995607 0.013756601316368553 0.017702208103780856 5.66935216086445e-07 6.246466565275749 -0.04216116097588385 QRS(ph)PIALPVKQEPPQIDAVK ddPTM_A459_Selumetinib_30min_R1 2 QRSPIALPVKQEPPQIDAVK 20 2 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 QRS(1)PIALPVKQEPPQIDAVK;QRS(1)PIALPVKQEPPQIDAVK 92.307 0.00055519 46823000.0 6440.0 5499.6 14057.0 13162.7 9612.900000000001 8036.1 7654.8 7235.4 4782.6 5341.799999999999 True False 6590.039469941373 4855.704275305324 12148.13660957392 10864.08153948031 8743.414892295343 7955.264130195007 7077.3922730851655 7043.493688108527 8115.722892716469 6027.47206353827 1.0933338886473183 0.8055954841630422 2.015461288167742 1.802427522675706 1.450594013564411 1.3198342599243964 1.1741891457113727 1.1685651320918489 1.3464554969587608 1.0 12.557337343822415 -7.0052663330429 3.08462085437303 1.1878441812630869 1.450139675683197 0.12432889129647962 0.3237132000197869 0.6471986918634264 12.629386815717533 0.14246581375119316 0.11506169264717325 9.879470458787965e-08 7.0052663330429 0.26229549442011013 QRS(ph)PIALPVKQEPPQIDAVK ddPTM_A459_Selumetinib_30min_R2 2 QRSPIALPVKQEPPQIDAVK 20 2 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 QRS(1)PIALPVKQEPPQIDAVK;QRS(1)PIALPVKQEPPQIDAVK 68.26100000000001 0.0052932 17483000.0 63296.0 85988.0 77681.0 89892.0 82777.0 46460.0 36715.0 37394.0 27058.6 79549.0 True False 59778.261713963795 92583.00310500186 72683.08903267799 77648.55452765066 72377.81322423075 52859.44327811139 38422.3202493923 37502.81034909006 32471.07608045313 77252.21367687646 0.7738064563948792 1.1984511342581021 0.9408544502904501 1.0051304788809285 0.936902773129144 0.6842450301710067 0.4973620614951138 0.4854593617983998 0.4203255095869511 1.0 16.237288653859586 -6.827474118125088 2.7276813331387473 0.5591005715199944 0.991501940935983 0.49525432489706245 0.17801920577881067 0.19527987202513608 2.9591420767749828 0.06412537645587985 0.057218238948899006 1.4877360333928868e-07 6.827474118125088 0.4324013694159886 QS(ph)EAADSSPSELK ddPTM_A459_Selumetinib_30min_R1 1 QSEAADSSPSELK 13 0 P04090 P04090 RLN2 Prorelaxin H2;Relaxin B chain;Relaxin A chain 1 QS(0.333)EAADS(0.333)S(0.333)PSELK 88.021 0.024354 5897500.0 5207.4 7888.0 7494.7 8606.0 6264.8 6767.1 6333.8 6037.8 3395.0 6098.8 True False 5328.722288163461 6964.469292968289 6476.960905440257 7103.1236546276605 5698.149946140274 6699.029118035197 5856.036366628367 5877.657930461579 5761.067039010665 6881.640387342688 0.7743389640011574 1.0120362153445197 0.9411943288046913 1.0321846616240429 0.82802204495033 0.9734639912827521 0.8509651822840524 0.8541071023229111 0.8371647913493011 1.0 12.748536788048689 -7.273598700674481 24.62802616429844 0.8734015281103988 0.9316889952149874 0.044596373991352856 0.08491900067535792 1561.011994502543 3161727.1500861323 0.03377745555021279 0.02298628899534351 5.3260016828389395e-08 7.273598700674481 0.05828746710458854 QS(ph)FDDNDSEELEDK ddPTM_A459_Selumetinib_30min_R2 1 QSFDDNDSEELEDK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 QS(0.662)FDDNDS(0.338)EELEDK 138.01 0.0007067 0.0 6380.3 5514.8 4520.1 5675.8 5433.6 5107.2 8536.1 6693.6 4394.4 5273.4 True False 6025.708468364567 5937.767427123133 4229.281687112769 4902.746248698879 4750.982590999681 5810.670441454381 8933.045563961266 6713.077267814869 5273.402789794862 5121.14324006134 1.176633455832099 1.1594613055681706 0.8258471768624287 0.9573538600416407 0.9277191377569776 1.134643217162733 1.744345968314346 1.3108552042247623 1.0297315545760242 1.0 12.3222501969682 -7.0064087137202575 24.50887423869179 1.3174744609757503 1.0073034243307288 0.2384347576554252 0.21434289810457502 284.2559077507166 1087084.425243758 0.07893137611353278 0.06717709130872272 9.853517364818781e-08 7.0064087137202575 -0.31017103664502144 QS(ph)GDGQESTEPVENK ddPTM_A459_Selumetinib_30min_R1 1 QSGDGQESTEPVENK 15 0 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 QS(1)GDGQESTEPVENK 260.58 2.1008e-36 15557000.0 2836.9 3425.6 1796.3 1897.1 2127.0 2229.0 2878.4 2761.2 1499.6 3182.7 True False 2902.994250353521 3024.5291594817636 1552.372326369612 1565.807097977473 1934.6132255523503 2206.5782837700717 2661.279970586864 2687.96400635836 2544.711673549452 3591.230547123298 0.8083564149561273 0.842198549994101 0.4322675211183857 0.4360085150288498 0.5387048255930111 0.6144351510758947 0.7410496028216965 0.748479934965889 0.7085904511443454 1.0 11.810262557691098 -8.702895662466718 0.7049557926817259 0.9965463407369224 0.6106714020684241 0.4076721426846348 0.13310182534388756 1.0662884149968874 1.1273522010361703 0.15205835339910717 0.05733623877259248 1.9820031370332203e-09 8.702895662466718 -0.3858749386684983 QS(ph)GDGQESTEPVENK ddPTM_A459_Selumetinib_30min_R2 3 QSGDGQESTEPVENK 15 0 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 QS(0.996)GDGQES(0.003)T(0.001)EPVENK;QS(1)GDGQESTEPVENK;QS(1)GDGQESTEPVENK 218.05 1.1089999999999999e-20 40966100.0 83851.6 61418.700000000004 78609.4 92257.0 84241.7 75990.0 91963.9 93189.5 85682.8 68540.7 True False 79191.46375655034 66129.31679775285 73551.75678744316 79691.43744779806 73658.50451564658 86456.93273146123 96240.40357301084 93460.6660166477 102821.75417746088 66561.75190087466 1.1897442824895015 0.9935032493771228 1.1050153381926933 1.1972557087511224 1.1066190779554685 1.2988980948129933 1.4458814683293544 1.4041196835658942 1.5447573304648814 1.0 16.02240578516551 -6.87573940039325 3.4362482604995117 1.3821400320337245 1.1139075853339757 0.3652425188245052 0.14320721705955836 0.222877699788383 5.1392464704383505 0.05062921084517235 0.044394905722100024 1.331253000408452e-07 6.87573940039325 -0.26823244669974877 QS(ph)HSESPSLQSK ddPTM_A459_Selumetinib_30min_R2 1 QSHSESPSLQSK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QS(0.994)HS(0.006)ESPSLQSK 201.08 8.4836e-05 2489900.0 26291.0 24113.0 25199.0 31621.0 31079.0 22050.0 27980.0 36231.0 25426.0 34132.0 True False 24829.851471211805 25962.389564484674 23577.72377459674 27314.165250732443 27174.578170214787 25087.187350029188 29281.125441318185 36336.42621163508 30511.910461797783 33146.5204744138 0.7490937545127329 0.7832613858979665 0.7113182149178122 0.8240432135800371 0.8198319998984862 0.7568573410109302 0.8833845912701648 1.0962365186923195 0.920516241979314 1.0 15.01656981224695 -7.520393152039362 4.34921051643911 1.0062841728157077 0.7777443595724024 0.8077958615748692 0.05058837545142229 0.08112049744718822 3.8046128054592128 0.023226178380077366 0.013839405803702255 3.017219097773878e-08 7.520393152039362 -0.2285398132433053 QS(ph)LSPMSQRPVLK ddPTM_A459_Selumetinib_30min_R2 1 QSLSPMSQRPVLK 13 1 Q9NSV4-1;Q9NSV4-7;Q9NSV4-6;Q9NSV4-5;Q9NSV4-4;Q9NSV4 Q9NSV4-1 DIAPH3 Protein diaphanous homolog 3 1 QS(0.751)LS(0.249)PMSQRPVLK 85.28 0.015407 24392000.0 60398.0 43902.0 80038.0 65298.0 98043.0 48937.0 65225.0 78877.0 71168.0 68577.0 True False 57041.32095235068 47269.14223282073 74888.44221878552 56404.299754667096 85725.96182445917 55677.627544144154 68258.09174088557 79106.51901120972 85403.58860006405 66597.00382555606 0.8565148231257445 0.7097788116209753 1.1245016730024073 0.8469495099571192 1.2872345135677488 0.8360380249235524 1.0249423820879473 1.1878390087701398 1.282393856993475 1.0 16.023169651992447 -4.860046175960543 0.4881458624746961 1.1237854587372251 0.5540346646915257 0.3024290123200073 0.15985894167336995 5.313222809315006 1.0333549612476256 0.10517200836902786 1.73560961293867 1.380237504320327e-05 4.860046175960543 -0.5697507940456994 QS(ph)NVAAPGDATPPAEK ddPTM_A459_Selumetinib_30min_R2 1 QSNVAAPGDATPPAEK 16 0 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 1 QS(0.731)NVAAPGDAT(0.269)PPAEK 134.81 0.00042079 7865900.0 67263.0 63031.0 68835.0 74309.0 75334.0 60484.0 72422.0 70571.0 65783.0 59291.0 True False 63524.79173512302 67865.27502339115 64406.231041881285 64187.98600982507 65869.86942549507 68815.12198091445 75789.76650147057 70776.34992634195 78941.43813059249 57579.1147734814 1.1032609998439913 1.178643945645499 1.1185693162400645 1.1147789656430678 1.1439889217579993 1.195140325648214 1.316271825289962 1.2292017722880773 1.3710081935290486 1.0 15.813257988497243 -6.912581689752215 3.4115297953664063 1.2491979141220773 1.1324984390341233 0.185396499737165 0.09258738784593626 0.3261737848807804 7.538747910616793 0.03248488299462852 0.027996097315956512 1.222977058357174e-07 6.912581689752215 -0.11669947508795397 QS(ph)PASPPPLGGGAPVR ddPTM_A459_Selumetinib_30min_R2 1 QSPASPPPLGGGAPVR 16 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 QS(0.986)PAS(0.014)PPPLGGGAPVR 113.67 0.002454 0.0 18755.0 9851.8 15789.0 16734.0 15022.0 8728.3 17685.0 15340.0 10385.0 12268.0 True False 17712.672182213584 10607.401381470158 14773.152929763399 14454.800332239867 13134.802061616085 9930.544097381398 18507.387542162698 15384.636860326284 12462.290181144104 11913.790963908015 1.4867368611613943 0.8903464408268139 1.2400043759805437 1.2132830243563664 1.1024872017149736 0.833533518211397 1.5534423592145872 1.2913300986170522 1.0460390163716762 1.0 13.540344930836152 -7.257091883029527 24.996147362718737 1.2469803656633809 1.1247861707060482 0.03780110318009722 0.22128379779619894 1169.2178894278848 6722504.492500641 0.08441958891838001 0.06309383272506355 5.532330501498685e-08 7.257091883029527 -0.12219419495733264 QS(ph)PDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK ddPTM_A459_Selumetinib_30min_R2 3 QSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 38 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QS(0.688)PDHPT(0.14)VGAGVLHIT(0.138)ENGPT(0.032)EVDY(0.001)S(0.001)PSDMQDSSLSHK;QS(0.915)PDHPT(0.077)VGAGVLHIT(0.007)ENGPT(0.001)EVDYSPSDMQDSSLSHK;QS(0.532)PDHPT(0.122)VGAGVLHIT(0.138)ENGPT(0.138)EVDY(0.032)S(0.034)PS(0.003)DMQDS(0.001)SLSHK 61.357 3.7906e-05 27394500.0 28459.0 25311.199999999997 39509.2 57242.8 63704.6 36511.0 28747.1 34019.5 37503.3 54312.9 True False 26877.36271040344 27252.48765166444 36967.22108636441 49446.23189066212 55701.458621650105 41540.05883614133 30083.897111297985 34118.4911127686 45005.007929754596 52744.74545513857 0.509574223526468 0.5166863052708014 0.7008702149829588 0.9374627076874993 1.0560570184005595 0.7875677184085143 0.5703676613035416 0.6468604752636011 0.8532605009542247 1.0 15.686739756148338 -5.405220309576234 3.4434036186718893 0.8175465586247032 0.5122100013710728 0.44875054799279257 0.14093615049010677 0.25835946991647074 5.574173203508965 0.04288693856502813 0.09909474584378583 3.9335048539349815e-06 5.405220309576234 -0.3053365572536304 QS(ph)PECENFLDVGLGR ddPTM_A459_Selumetinib_30min_R1 2 QSPECENFLDVGLGR 15 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;A0A087X047 Q12802-4 AKAP13 A-kinase anchor protein 13 1 QS(1)PECENFLDVGLGR;QS(1)PECENFLDVGLGR 129.42 0.00088523 16909200.0 3098.3 3563.6 2871.1 3418.9 2972.6 3320.3 3450.7 2985.4 1863.81 2932.2 True False 3170.4843617576644 3146.372055327305 2481.2203898234116 2821.8532957014295 2703.7288548551546 3286.9007965911906 3190.4109208254895 2906.217494054124 3162.7494427035263 3308.576432046673 0.9582623907516667 0.9509745716773336 0.7499359439880124 0.8528904662347008 0.8171879690210566 0.9934486520409402 0.9642850894793787 0.8783891059322904 0.9559245517405386 1.0 11.691994892571337 -6.763007880053375 24.999986194131694 0.9511760245292362 0.8634197226693503 0.337609637085038 0.06438237001786616 57.287427526585134 913077.9173812536 0.02356433565692078 0.02189161891562814 1.725806577819996e-07 6.763007880053375 -0.08775630185988592 QS(ph)PECENFLDVGLGR ddPTM_A459_Selumetinib_30min_R2 1 QSPECENFLDVGLGR 15 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;A0A087X047 Q12802-4 AKAP13 A-kinase anchor protein 13 1 QS(1)PECENFLDVGLGR 107.73 0.0041659 3174800.0 5896.6 3874.1 4727.7 6434.3 7486.8 5010.8 6526.8 6933.0 3423.8 5016.8 True False 5568.890577960044 4171.231012805128 4423.524929130561 5557.937240213396 6546.241251158792 5700.992216486452 6830.30913260885 6953.173882180066 4108.655668964964 4871.95194878821 1.1430512116083538 0.8561724451823932 0.9079574215075776 1.140802967401148 1.3436588291448615 1.1701659368591366 1.4019656196132513 1.4271844129968307 0.8433284466171513 1.0 12.2502841889271 -5.913153543008083 4.6514625377008265 1.2291907469482055 0.9598965731452126 0.2265145190445057 0.18295884379097307 0.2585404232076128 9.9859520753969 0.051301996415118095 0.07764740763898897 1.2213677743260379e-06 5.913153543008083 -0.2692941738029929 QS(ph)PGPALAR ddPTM_A459_Selumetinib_30min_R2 3 QSPGPALAR 9 0 P85037 P85037 FOXK1 Forkhead box protein K1 1 QS(1)PGPALAR;QS(1)PGPALAR;QS(1)PGPALAR 92.112 0.026325 138470000.0 164767.0 153391.0 185752.0 205201.0 196691.0 138213.0 142184.0 144341.0 117155.0 160163.0 True False 155609.9097545609 165155.5964701971 173800.91855148596 177252.26980853046 171980.91814014973 157250.5861773053 148795.83773225104 144761.00841306118 140589.27358420193 155538.67803655012 1.0004579678759649 1.0618297554990606 1.117412856695647 1.139602522318454 1.1057115844827732 1.0110063179291835 0.9566484659030303 0.9307074628668486 0.9038862574823014 1.0 17.246913856547906 -7.038248547562838 2.5903833185314484 0.9410437191377805 1.088298142169872 0.701058516202256 0.04204959946922804 0.1640985357060636 2.192100563946954 0.018902692095290604 0.014731622141203658 9.156962853986806e-08 7.038248547562838 0.14725442303209157 QS(ph)PKCIISLEVMS(ph)SSMEICVIK ddPTM_A459_Selumetinib_30min_R2 1 QSPKCIISLEVMSSSMEICVIK 22 1 Q8TAB3-3;Q8TAB3-2;Q8TAB3 Q8TAB3-3 PCDH19 Protocadherin-19 2 QS(0.957)PKCIIS(0.043)LEVMS(0.333)S(0.333)S(0.333)MEICVIK 44.587 0.042582 6835900.0 0.0 492.5 923.22 1052.2 418.3 863.27 613.39 783.38 663.15 2146.8 True False 0.0 530.2731663629039 863.8210303259336 908.8885448537578 365.74941435055314 982.1776065151793 641.9138504092267 785.6595061044601 795.798529959144 2084.8163059437347 0.0 0.2543500666466943 0.41433915681837846 0.4359561762168446 0.17543483965844617 0.4711099024480128 0.30789947708062043 0.3768483121820247 0.38171158182634685 1.0 11.025704557454835 -14.522878745277954 0.19837501480814157 4.048109432906328 0.2101955990356926 0.7532023159319524 0.12211537572341978 71.43782508372512 0.7036734987525026 86.25095923995094 0.3050459131419696 3.0000000000164685e-15 14.522878745277954 -3.837913833870635 QS(ph)PLTYEDHGAPFAGHLPR ddPTM_A459_Selumetinib_30min_R1 1 QSPLTYEDHGAPFAGHLPR 19 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 QS(0.995)PLT(0.004)Y(0.001)EDHGAPFAGHLPR 144.08 4.3862e-05 9067900.0 1162.5 1013.5 1006.7 1204.2 1366.2 933.88 1041.7 999.48 569.18 908.54 True False 1189.5839881687648 894.8389488366323 869.9956694072753 993.9090756335846 1242.6274512222012 924.4860150951963 963.1237303225182 972.9705436314114 965.8568887375811 1025.1599589290233 1.160388657211616 0.8728773895651013 0.8486438256095693 0.9695160906127408 1.2121303025923529 0.9017968435491761 0.9394862937572065 0.9490914419325021 0.9421523737101518 1.0 10.001633320196394 -10.199083895817296 7.594804904076329 0.9999978976760396 0.9729938781575385 0.0023195911559469318 0.11203377855764 0.0 0.0 0.10998375568714418 0.02667497892942486 6.322896955879132e-11 10.199083895817296 -0.027004019518501177 QS(ph)PLTYEDHGAPFAGHLPR ddPTM_A459_Selumetinib_30min_R2 1 QSPLTYEDHGAPFAGHLPR 19 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 QS(0.985)PLT(0.013)Y(0.002)EDHGAPFAGHLPR 132.24 0.00013089 11459000.0 19909.0 19040.0 23098.0 21376.0 25956.0 16512.0 19108.0 15260.0 10456.0 20421.0 True False 18802.537482041604 20500.306776750644 21611.8998272009 18464.551924343217 22695.17523041586 18786.378118987846 19996.5598617837 15304.404073570999 12547.492165049847 19831.392669870045 0.9481198721161128 1.0337300621300733 1.0897822551835197 0.9310769158636308 1.1444065279841278 0.9473050345843892 1.0083285725144555 0.7717261378633823 0.6327085734182112 1.0 14.275498374683783 -7.754485146517158 7.8821154743082875 0.776058618246944 1.017785114140351 0.4603005776327945 0.10468719910051771 0.09373441323178201 41.00323746677661 0.049404164947128064 0.026504851524627532 1.7600088575534294e-08 7.754485146517158 0.2417264958934071 QS(ph)PNSSSAAASVASR ddPTM_A459_Selumetinib_30min_R1 2 QSPNSSSAAASVASR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 QS(0.999)PNS(0.001)SSAAASVASR;QS(0.955)PNS(0.044)S(0.001)SAAASVASR 130.95 0.00075302 23686600.0 2496.17 3302.99 2125.15 2284.44 2835.39 2339.6 2720.34 3058.23 1858.6 2931.27 True False 2554.325904298689 2916.274395281608 1836.5663026133607 1885.505438249781 2578.929475128764 2316.065748186835 2515.142563641701 2977.1158058689434 3153.908453226868 3307.527057487703 0.7722766465405356 0.8817084016530227 0.5552687160806964 0.570065007928296 0.779715307026888 0.70024090746095 0.760429928440896 0.900103235475954 0.9535548457833269 1.0 11.691537243295642 -7.848458562586448 1.571761515028413 0.9889644628901182 0.7048480218971376 0.5949940390256487 0.09092595923116363 0.3064596810520824 1.3986247315642604 0.08143833603527757 0.029838854745609735 1.4175599588809003e-08 7.848458562586448 -0.2841164409929806 QS(ph)PNSSSAAASVASR ddPTM_A459_Selumetinib_30min_R2 3 QSPNSSSAAASVASR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 QS(0.943)PNS(0.04)S(0.011)S(0.006)AAASVASR;QS(0.93)PNS(0.047)S(0.015)S(0.008)AAASVASR;QS(0.997)PNS(0.002)SSAAASVASR 159.4 0.0001379 74167000.0 37732.0 27129.5 35834.0 38820.0 41116.0 35418.7 37747.0 44896.0 42477.0 30852.800000000003 True False 35635.006493163615 29210.245414908433 33528.47945310925 33532.64903176476 35950.64049829631 40297.30442605347 39502.31029426151 45026.63992706708 50973.58690654385 29961.99949879861 1.1893400670603602 0.9749097491333875 1.1190334428265925 1.119172605056259 1.199874544412092 1.3449471030018967 1.3184136891746974 1.5027915586498999 1.7012745397244848 1.0 14.870846284078606 -6.731894512173974 1.287447955596102 1.430709594414347 1.0832495878125956 0.3533924947463023 0.1724251627473137 0.42165339154590786 1.4687643617681125 0.07997661044494417 0.07411792971279375 1.853981891096053e-07 6.731894512173974 -0.34746000660175147 QS(ph)PPISTSK ddPTM_A459_Selumetinib_30min_R2 1 QSPPISTSK 9 0 P33981-2;P33981 P33981-2 TTK Dual specificity protein kinase TTK 1 QS(0.997)PPIS(0.003)TSK 92.792 0.025424 12645000.0 76667.0 60699.0 74074.0 81499.0 87003.0 70106.0 91764.0 81381.0 71682.0 75769.0 True False 72406.1550623178 65354.41812195311 69308.15948567304 70398.69560638315 76072.90532331137 79762.465141095 96031.20782691649 81617.80523665009 86020.40296242388 73581.35209849577 0.9840286023202611 0.8881926773303905 0.9419256035537014 0.9567464255365635 1.0338612046905635 1.0840037980591226 1.305102516985138 1.1092186119031455 1.1690516755831997 1.0 16.167052566432126 -6.609045917885929 1.93037135904523 1.1562353771512395 0.9374172840242726 0.5906304817185802 0.07502734368868468 0.21185710080729403 1.6118757519256057 0.027991396774761437 0.02857537060760818 2.460107483626873e-07 6.609045917885929 -0.21881809312696687 QS(ph)QQPMKPISPVKDPVS(ph)PASQK ddPTM_A459_Selumetinib_30min_R2 1 QSQQPMKPISPVKDPVSPASQK 22 2 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 2 QS(0.651)QQPMKPIS(0.349)PVKDPVS(0.96)PAS(0.04)QK 63.488 0.024427 43938000.0 133350.0 107190.0 126110.0 133370.0 124290.0 87818.0 142710.0 130540.0 74776.0 101520.0 True False 125938.94084234508 115411.1283298266 117996.21989818638 115204.77592391743 108675.57903330207 99914.13236756755 149346.29777450045 130919.84978793975 89733.28941600696 98588.85381936256 1.2774156100150447 1.1706305921893192 1.1968515235442596 1.168537531991183 1.1023110100500886 1.0134424785040428 1.5148395786012199 1.3279376391555886 0.9101768195867148 1.0 16.5891369282976 -4.760551061227745 22.764310683760723 1.1730656524878695 1.2774159026154068 0.03783376089004187 0.1646010289503382 31.76549629063193 812472.965073873 0.041329278740693455 0.24160199524534223 1.7355971918156683e-05 4.760551061227745 0.10435025012753729 QS(ph)SPSCGPVAETSSIGNGDGISK ddPTM_A459_Selumetinib_30min_R2 1 QSSPSCGPVAETSSIGNGDGISK 23 0 Q9Y4K4 Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1 QS(0.454)S(0.241)PS(0.275)CGPVAET(0.009)S(0.009)S(0.01)IGNGDGISK 50.271 0.030092 2246600.0 11007.0 8040.3 13690.0 11926.0 12303.0 10004.0 10825.0 9829.0 11958.0 11243.0 True False 10395.275004512132 8656.965156360722 12809.200304544995 10301.658226502494 10757.387149784503 11381.960192729803 11328.38394933057 9857.600762721451 14349.93413443631 10918.385377177841 0.9520890356408246 0.792879611527172 1.1731771559666166 0.9435148028421435 0.9852543923087873 1.0424581840205924 1.0375512090835086 0.9028441864056479 1.31429086249614 1.0 13.414471904253398 -2.4734198039293585 0.33074033466063274 1.0664122313635542 0.07663625440455042 0.1427764443989472 0.12693051825046658 61.1185212790804 1.5536824308465234 0.11230701661513927 32.99900045245641 0.0033618644292487533 2.4734198039293585 -0.9897759769590038 QS(ph)SPSGSEQLVR ddPTM_A459_Selumetinib_30min_R2 1 QSSPSGSEQLVR 12 0 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 QS(0.484)S(0.484)PS(0.025)GS(0.008)EQLVR 158.31 0.00045283 34013000.0 78299.0 58207.0 66304.0 81349.0 82169.0 56444.0 63045.0 65895.0 53679.0 61956.0 True False 73947.45503573131 62671.28973499606 62038.07282633687 70269.12586514758 71846.19561981974 64218.648652383155 65976.71742129754 66086.74354049556 64416.29991657528 60167.1692989799 1.2290333066572412 1.0416193825501878 1.0310950897167883 1.1678981524952505 1.194109619197888 1.0673370444481247 1.0965567798852078 1.0983854535702084 1.0706220795676924 1.0 15.87668886305165 -8.753828899102425 0.6955465327058387 0.9989896197621676 1.1190336474147438 0.27341158059293025 0.06040384298865297 1.5691708479504731 1.5694298231272878 0.0644769593469678 0.02406878331208158 1.7626703565865414e-09 8.753828899102425 0.12004402765257616 QS(ph)SQDNELK ddPTM_A459_Selumetinib_30min_R1 1 QSSQDNELK 9 0 Q13427;E9PG73 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 QS(0.736)S(0.264)QDNELK 121.29 0.0035481 0.0 3303.7 3753.5 3461.7 3724.9 3315.9 3683.2 2687.7 2843.5 2334.9 2874.9 True False 3380.669782118836 3314.0384750451904 2991.6201537569927 3074.4161400328326 3015.977430469695 3646.1503520780284 2484.9646251203153 2768.0811430102844 3962.1547656512544 3243.9214188974083 1.0421552638189082 1.0216149058788282 0.9222233733312284 0.9477467987118536 0.9297319635735225 1.1239946599314774 0.7660372445041969 0.8533132544101949 1.2214089843760672 1.0 11.663523156640167 QS(ph)STDSSGGHPGPR ddPTM_A459_Selumetinib_30min_R2 3 QSSTDSSGGHPGPR 14 0 Q9GZV5;C9JR84;C9J038;C9JQS8 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 QS(0.722)S(0.236)T(0.042)DS(0.001)SGGHPGPR;QS(0.433)S(0.433)T(0.132)DS(0.001)SGGHPGPR;QS(0.322)S(0.322)T(0.322)DS(0.034)S(0.001)GGHPGPR 166.36 0.00015504 6110100.0 2842.2599999999998 2667.43 3067.47 5837.82 6367.6 3257.0499999999997 2846.04 5014.4 4095.08 6645.200000000001 True False 2684.29856766827 2872.013303860711 2870.1123198088103 5042.698845198792 5567.645160933736 3705.6790729438794 2978.3864993212705 5028.991073821394 4914.210426095288 6453.335809696896 0.4159551969440047 0.44504321308449085 0.44474863922254426 0.7814096451670071 0.8627546008945784 0.5742269087214803 0.46152665646903024 0.7792855078554479 0.7614992572850632 1.0 12.655829385051867 -7.019890569139881 0.10087459056111825 1.3108437586700543 4.974776631835475e-14 0.5406264836379775 0.1345825234546617 17.66704786789213 0.9051533542653345 4.427965335229508 6.699611545494669 9.552332495156875e-08 7.019890569139881 -1.3108437586700046 QS(ph)STPSAPELGQQPDVNISEWK ddPTM_A459_Selumetinib_30min_R2 2 QSSTPSAPELGQQPDVNISEWK 22 0 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L213 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 QS(0.768)S(0.179)T(0.043)PS(0.01)APELGQQPDVNISEWK;QS(0.719)S(0.215)T(0.065)PS(0.001)APELGQQPDVNISEWK 129.82 1.6654e-05 4556600.0 32494.0 24257.9 28288.0 33382.0 31819.0 25600.0 30387.0 34251.0 21661.5 26331.0 True False 30688.113563788225 26118.402928557727 26467.98087764564 28835.314012837996 27821.61275453084 29126.167626337763 31800.055710698194 34350.664739441716 25994.40527287942 25570.75561384593 1.2001254099496135 1.0214169390604657 1.0350879448909944 1.1276676547338471 1.088024662809187 1.1390421177294685 1.2436103254406472 1.3433574376207202 1.0165677411114162 1.0 14.642207172285511 -6.938549419170722 4.172067171004558 1.181035260909735 1.0894208130752423 0.030563333276046878 0.10560338999174711 0.44121042742446914 15.6018288992149 0.03809597130072943 0.03283443135538161 1.151994964733768e-07 6.938549419170722 -0.09161444783449268 QSAGPNS(ph)PTGGGGGGGSGGTR ddPTM_A459_Selumetinib_30min_R1 1 QSAGPNSPTGGGGGGGSGGTR 21 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 QS(0.002)AGPNS(0.681)PT(0.317)GGGGGGGSGGTR 195.05 1.8132999999999998e-16 2290800.0 242.28 264.34 286.32 335.16 270.04 215.58 198.16 236.88 182.37 167.24 True False 247.9246526051856 233.3909499116679 247.4393166431818 276.6305977323967 245.6149296794343 213.41146093097882 183.21263166046873 230.5971729053195 309.46857022220183 188.70688305555055 1.313808211925173 1.2367908691648704 1.311236308059531 1.4659274386454872 1.3015684732979849 1.1309150862724804 0.9708847324161226 1.2219860196484593 1.639943202978463 1.0 7.5600032357602815 -6.625092364542785 6.560807644103663 1.193445273793362 1.3307733891224611 0.12352832260835478 0.17857664578234594 0.515236181416055 28.807246344399395 0.061542207567355595 0.06145153831740652 2.370869422122636e-07 6.625092364542785 0.13732811532909905 QSAGPNS(ph)PTGGGGGGGSGGTR ddPTM_A459_Selumetinib_30min_R2 3 QSAGPNSPTGGGGGGGSGGTR 21 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 QS(0.001)AGPNS(0.697)PT(0.303)GGGGGGGSGGTR;QS(0.01)AGPNS(0.687)PT(0.303)GGGGGGGSGGTR;QSAGPNS(0.697)PT(0.302)GGGGGGGSGGTR 282.87 4.056699999999998e-73 8781300.0 13815.0 9868.380000000001 15585.8 16669.2 15089.099999999999 12788.6 17188.5 15562.0 14607.0 12381.5 True False 13047.217605826756 10625.253014157059 14583.026596535967 14398.826204026112 13193.47235973447 14550.11356664777 17987.79930836661 15607.28284357221 17528.80815368049 12024.0139239996 1.0850966813823184 0.8836693870546296 1.2128251587790204 1.1975057825978106 1.097260236317646 1.2100878840140183 1.4959895607292553 1.2980093787500115 1.4578166878777037 1.0 13.553630964581163 -6.984379325839147 4.470549176885982 1.3406856712968822 1.0980977013909279 0.31098647715926353 0.15019414540385306 0.21892825551822856 10.84711531101183 0.05483419096694587 0.046018043277407064 1.036622602989973e-07 6.984379325839147 -0.24258796990595433 QSAGPNSPT(ph)GGGGGGGSGGTR ddPTM_A459_Selumetinib_30min_R1 1 QSAGPNSPTGGGGGGGSGGTR 21 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 QSAGPNS(0.221)PT(0.779)GGGGGGGSGGTR 181.23 5.2730999999999996e-14 2284500.0 422.33 465.72 433.21 510.58 586.32 372.25 511.74 612.23 333.39 537.84 True False 432.16946728887245 411.1932858926459 374.38246145219614 421.4167877736219 533.2874595232034 368.50550297595737 473.1390397957626 595.991671596689 565.7384801578103 606.8770030052457 0.7121203557702398 0.6775562162619823 0.6169000631071204 0.6944023017625851 0.87874059633562 0.6072161264162651 0.7796292122667118 0.9820633648092567 0.9322127504523683 1.0 9.245260341947693 -7.651906402298611 3.858456840769989 0.9688953834209276 0.7006029815162208 0.7433022177921145 0.07171963471561377 0.1177927818003728 3.2672939596060133 0.0379154015467729 0.020334310342510955 2.2289154659536147e-08 7.651906402298611 -0.2682924019047068 QSAGPNSPT(ph)GGGGGGGSGGTR ddPTM_A459_Selumetinib_30min_R2 1 QSAGPNSPTGGGGGGGSGGTR 21 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 QSAGPNS(0.231)PT(0.768)GGGGGGGSGGTR 278.23 2.0653999999999993e-72 6785200.0 8392.5 5624.9 5161.3 6984.1 8229.2 5700.0 6936.1 6162.9 5457.0 7114.1 True False 7926.078447839382 6056.311743095831 4829.227577198542 6032.8535317555 7195.37432601858 6485.123260551766 7258.642393621407 6180.833018676983 6548.552481319537 6908.697448348389 1.147260899336996 0.8766213585664644 0.6990069565650222 0.8732258977700246 1.0414950690507838 0.9386897181468146 1.0506528108792312 0.8946452011955724 0.9478707861038336 1.0 12.754198018148852 -6.235665389924326 24.015492918835463 0.9752024300563295 0.8831409548066046 0.10354610447846058 0.11094032219225927 1026.3021975972156 956278.9091030234 0.033990461283643546 0.043861674435950536 5.812120504418816e-07 6.235665389924326 -0.09206147524972486 QSAGPNSPTGGGGGGGS(ph)GGTR ddPTM_A459_Selumetinib_30min_R1 1 QSAGPNSPTGGGGGGGSGGTR 21 0 H7BZ52;S4R3H3;S4R393;S4R410;A7E2V4-5;A7E2V4;A7E2V4-3;A7E2V4-4;A7E2V4-2 H7BZ52 ZSWIM8 Zinc finger SWIM domain-containing protein 8 1 QSAGPNS(0.123)PT(0.322)GGGGGGGS(0.454)GGT(0.1)R 71.08 0.0056734 328520.0 0.0 58.981 131.69 0.0 129.72 0.0 69.148 74.562 0.0 0.0 True False 0.0 52.075477100476995 113.80722132139074 0.0 117.9868489039261 0.0 63.93211068862582 72.58437354849052 0.0 0.0 0.0 QSDEVGDRDHR ddPTM_A459_Selumetinib_30min_R2 1 QSDEVGDRDHR 11 1 P40222 P40222 TXLNA Alpha-taxilin 0 77.288 0.039635 5955500.0 23427.0 24749.0 18382.0 20021.0 20203.0 19057.0 27286.0 45193.0 23090.0 40793.0 False True 22125.021125711428 26647.168719422345 17199.322132808345 17294.10526184859 17664.918522888416 21681.928767778078 28554.85306618328 45324.50414789612 27708.64518850431 39615.20009705735 0.5584982802435697 0.672650110415616 0.43415966827555985 0.436552263259506 0.4459126416024485 0.5473133725099782 0.7208054735612546 1.144119025950922 0.6994447868650935 1.0 15.273766468871491 -7.46800271108045 3.3991982158333367 0.9430880834672033 0.5136363723608313 0.7081575558197404 0.12375715075791804 0.13087298927929786 3.0135189828526565 0.0582407744196458 0.03521089069172164 3.4040606471174584e-08 7.46800271108045 -0.42945171110637204 QSDSQPNSDNLS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 QSDSQPNSDNLSR 13 0 Q5RGS4;Q9HB21-2;R4GMZ9;Q9HB21 Q5RGS4;Q9HB21 PLEKHA1 Pleckstrin homology domain-containing family A member 1 1 QSDSQPNSDNLS(1)R 85.28 0.043757 0.0 5374.7 2857.2 4819.4 5092.3 5253.1 4467.3 4854.6 5302.2 4438.5 4202.6 True False 5075.995690628816 3076.3380526539886 4509.32505096597 4398.719955292524 4593.158614690152 5082.63002488823 5080.3485192074095 5317.6285241735395 5326.324022051814 4081.260018333862 1.2437324913939314 0.753771638865067 1.1048855085706748 1.0777847859564367 1.1254266069931187 1.2453580516938414 1.244799031766032 1.302937940803981 1.3050685322975912 1.0 11.994798912731959 -6.327315692871709 1.3817577525679534 1.2420975040227957 1.00710986283841 0.24569817633533764 0.14023797320594283 0.4819781183430614 1.8614313180704203 0.05251942757960153 0.0693839692830275 4.7063509281127087e-07 6.327315692871709 -0.23498764118438564 QSEKPHS(ph)TPPQSCTSDLSK ddPTM_A459_Selumetinib_30min_R2 1 QSEKPHSTPPQSCTSDLSK 19 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 QS(0.068)EKPHS(0.465)T(0.465)PPQS(0.002)CTSDLSK 65.265 0.01039 12566000.0 44586.0 36139.0 56375.0 82511.0 73150.0 58188.0 52231.0 52528.0 50377.0 57887.0 True False 42108.08861189952 38910.745094799946 52747.893876459 71272.85946058574 63960.24303070272 66202.86882192738 54659.844993763065 52680.8477835215 60453.807650986615 56215.65190151153 0.7490456338685155 0.6921692407475882 0.9383133005176573 1.2678472462696702 1.1377657443652798 1.1776590074578022 0.9723243108436384 0.937120641699879 1.0753910273405747 1.0 15.778684249797095 -5.443459373077461 4.131900000563898 1.082118956687596 0.7265528843465788 0.6930562264854312 0.09498852359762451 0.13206150687159693 4.1488772683654345 0.02806414350734326 0.06074988431414287 3.601974441896645e-06 5.443459373077461 -0.3555660723410171 QSELSAEES(ph)PEKLGTSQLHR ddPTM_A459_Selumetinib_30min_R1 2 QSELSAEESPEKLGTSQLHR 20 1 F8W9X7;Q567U6 F8W9X7 CCDC93 Coiled-coil domain-containing protein 93 1 QSELS(0.005)AEES(0.794)PEKLGT(0.147)S(0.055)QLHR;QSELSAEES(1)PEKLGTSQLHR 96.133 0.00055761 39408000.0 3746.0 3358.7 4691.6 4377.0 4116.7 3864.8 3981.7 3728.4 1874.8 3196.7 True False 3833.274511552852 2965.4618425827325 4054.5064891141083 3612.639116465869 3744.3452118624173 3825.9236209576356 3681.357163314941 3629.5107204499886 3181.3986700256814 3607.0275834948498 1.062723925121413 0.8221345065815926 1.1240575225060232 1.0015557222231115 1.0380694699968223 1.0606859893349354 1.0206068786832156 1.0062331480518802 0.8820000946439183 1.0 11.816594740340681 -8.091180259748437 8.783048136637197 0.9412531769586953 1.0165365117867022 0.13266755949469777 0.07816878290917947 0.7328942737786996 65.0763615032388 0.051066923389831306 0.019232975891093018 8.106245274376622e-09 8.091180259748437 0.07528333482800698 QSELSAEES(ph)PEKLGTSQLHR ddPTM_A459_Selumetinib_30min_R2 2 QSELSAEESPEKLGTSQLHR 20 1 F8W9X7;Q567U6 F8W9X7 CCDC93 Coiled-coil domain-containing protein 93 1 QSELS(0.003)AEES(0.995)PEKLGT(0.001)S(0.001)QLHR;QSELS(0.007)AEES(0.991)PEKLGT(0.001)S(0.001)QLHR 73.461 0.0040594 40207000.0 57759.0 59480.0 64395.0 76593.0 68310.0 52532.0 62446.0 53342.0 42349.0 66980.0 True False 54548.98600759663 64041.924741655865 60251.895807974804 66160.90126970538 59728.28710085172 59767.8061619834 65349.86273440153 53497.21638875654 50819.98332992506 65046.11336506024 0.8386202216487514 0.9845618966075876 0.9262950957549345 1.0171384245264368 0.9182452880103208 0.9188528425448997 1.0046697543270042 0.8224506218920801 0.7812916206800328 1.0 15.989175235163211 -7.772855908533956 24.99717850494095 0.8514033263117914 0.9457786229878872 0.18114009510016893 0.07158564204418243 296.30180405764446 648760.710675287 0.036496197186970725 0.017774446481095243 1.687112687616014e-08 7.772855908533956 0.09437529667609579 QSFCLS(ph)PNSVDHR ddPTM_A459_Selumetinib_30min_R2 2 QSFCLSPNSVDHR 13 0 E9PPG5;E9PL28;P15622-2;P15622-3;P15622 E9PPG5 ZNF250 Zinc finger protein 250 1 QSFCLS(0.999)PNS(0.001)VDHR;QSFCLS(0.937)PNS(0.063)VDHR 99.021 0.0079916 6452000.0 31725.0 30797.0 38339.0 54372.0 53638.0 38308.0 32148.0 38751.0 37846.0 43419.0 True False 29961.851505237344 33159.030872037256 35872.31048034701 46966.43980306838 46899.51491019597 43584.57927459946 33642.9457000535 38863.75899442662 45416.25750559265 42165.38065388998 0.7105794146903593 0.786404162794583 0.8507526772923275 1.113862582875449 1.1122753828588818 1.0336579107955606 0.7978807537920272 0.9216982840362722 1.077098245083737 1.0 15.363771358179553 -5.549631504021256 4.645236345855901 1.0014994731568096 0.7610700253127219 0.574788076800054 0.0912441510696041 0.1558624630894456 8.23914181504857 0.02815790630533445 0.05281884453977078 2.8207753252539578e-06 5.549631504021256 -0.2404294478440877 QSFDDNDS(ph)EELEDK ddPTM_A459_Selumetinib_30min_R2 2 QSFDDNDSEELEDK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 QSFDDNDS(1)EELEDK;QSFDDNDS(1)EELEDK 151.11 0.00040811 10166300.0 50697.0 31192.0 43938.0 43768.0 42835.0 41154.0 64282.0 65640.0 52312.0 40960.0 True False 47879.463696170744 33584.32610191206 41111.076916077305 37806.722895988685 37453.68435024131 46822.58994118377 67271.24037236659 65831.00153271295 62775.86171940396 39777.37837313924 1.203685754426256 0.8443071784889372 1.0335290709816785 0.9504578844119779 0.9415825245922425 1.1771160357013875 1.6911934150439973 1.6549859298210345 1.5781799677827706 1.0 15.279660574456495 -7.063893349176064 4.178707264459339 1.532599300750189 0.9897222858151589 0.5615445707745423 0.20024810491708445 0.14409675475238432 4.96022399723552 0.07413006861026034 0.058089459251621525 8.631904976738821e-08 7.063893349176064 -0.5428770149350302 QSFDDNDS(ph)EELEDKDSK ddPTM_A459_Selumetinib_30min_R1 4 QSFDDNDSEELEDKDSK 17 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 QSFDDNDS(1)EELEDKDSK;QSFDDNDS(0.986)EELEDKDS(0.014)K;QS(0.001)FDDNDS(0.999)EELEDKDSK;QSFDDNDS(1)EELEDKDSK 140.95 0.0002764 545062000.0 13327.800000000001 16125.500000000002 17791.8 18244.0 12080.9 15498.099999999999 13485.3 13615.099999999999 10284.1 15161.099999999999 True False 13638.31180861562 14237.518963458428 15375.771283361832 15058.027882294573 10988.184728056129 15342.203185148921 12468.09296392268 13253.98331992239 17451.36657905437 17107.174866619862 0.7972275910517046 0.8322542485515355 0.8987907941108144 0.8802171018708846 0.6423143981240685 0.896828570746955 0.7288224421117524 0.7747616671519528 1.0201197284249492 1.0 14.062313907790298 -8.265399263143271 24.981995161429253 1.010059899399693 0.8077625981324216 0.5375621785401643 0.07554831917387662 274.3683246771824 1730888.753449307 0.06437927196370671 0.019047765453165968 5.427511306679837e-09 8.265399263143271 -0.2022973012672714 QSFDDNDS(ph)EELEDKDSK ddPTM_A459_Selumetinib_30min_R2 5 QSFDDNDSEELEDKDSK 17 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 QSFDDNDS(0.995)EELEDKDS(0.005)K;QSFDDNDS(1)EELEDKDSK;QSFDDNDS(0.988)EELEDKDS(0.012)K;QSFDDNDS(0.564)EELEDKDS(0.436)K;QSFDDNDS(1)EELEDKDSK 146.72 0.00023015 1298320000.0 452191.0 424410.0 375604.0 372825.0 324428.0 284133.0 380697.0 359175.0 239585.0 342260.0 True False 427060.0344839964 456960.8823067606 351438.0475667137 322045.5918410018 283670.4542168806 323269.7416474309 398400.1648367945 360220.1397853777 287508.69456421887 332378.06450172485 1.284862270090571 1.3748226225211357 1.0573442868245897 0.9689134941073423 0.8534572058542345 0.9725964983039769 1.1986355520604068 1.083766283811152 0.8650050206990325 1.0 18.34246564812505 -5.345112832121226 4.395547378451331 0.9986720980241616 1.330082884243571 0.6550004032764289 0.09639512766123984 0.13611053203112464 4.7149072278944315 0.027858832884484805 0.062451518353362476 4.517385649366745e-06 5.345112832121226 0.33141078621940945 QSFDDNDSEELEDKDS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 QSFDDNDSEELEDKDSK 17 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 QSFDDNDS(0.085)EELEDKDS(0.915)K 99.238 0.0026773000000000005 26281000.0 31780.0 32185.0 30893.0 27210.0 24466.0 18764.0 31030.0 27780.0 20851.0 26820.0 True False 30013.79482541978 34653.48600891383 28905.37801375518 23503.95106013187 21392.36235118488 21348.57067736725 32472.95648477852 27860.835200773436 25021.782625617296 26045.63691327135 1.1523540363156366 1.330491019448114 1.1097973188371781 0.902414140932588 0.8213414946395328 0.8196601506983786 1.246771449395126 1.0696929890233233 0.9606899884589746 1.0 14.668754096360969 -5.5270559205781 5.060607488358644 0.9767143872333371 1.239083314112217 0.43113390565342646 0.12362964580251957 0.1739563014986945 13.15499651741529 0.036892560139234344 0.070520732134971 2.9712834190382405e-06 5.5270559205781 0.2623689268788799 QSFTMVADT(ph)PENLR ddPTM_A459_Selumetinib_30min_R1 4 QSFTMVADTPENLR 14 0 Q14847;Q14847-2;C9J9W2;F6S2S5 Q14847 LASP1 LIM and SH3 domain protein 1 1 QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR 255.23 8.094e-28 152968000.0 8350.699999999999 8889.5 10055.1 10049.4 10184.500000000002 7283.1 9538.3 9035.6 5926.5 8099.700000000001 True False 8545.255062366372 7848.71320738357 8689.672648710726 8294.460940601348 9263.313773219514 7209.838626525705 8818.818351670614 8795.946536234826 10056.837645566036 9139.375392759166 0.9349933332573803 0.8587800445971235 0.9507950243071617 0.9075522761842985 1.013560924585562 0.7888765169048455 0.9649257167680716 0.9624231589396768 1.100385662409025 1.0 13.157879856011029 -7.943688512564635 2.494091272119199 1.0473528712617577 0.9134130878682148 0.41351714360989444 0.062126546909949766 0.2736298361928958 3.2707638487128996 0.04441099387271165 0.016349824396566875 1.138443514736675e-08 7.943688512564635 -0.13393978339354284 QSFTMVADT(ph)PENLR ddPTM_A459_Selumetinib_30min_R2 9 QSFTMVADTPENLR 14 0 Q14847;Q14847-2;C9J9W2;F6S2S5 Q14847 LASP1 LIM and SH3 domain protein 1 1 QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFTMVADT(1)PENLR;QSFT(0.001)MVADT(0.999)PENLR 265.6 3.0395999999999995e-36 148240200.0 198983.0 215083.0 229044.0 268349.0 237667.0 196243.0 222601.0 207367.0 187033.0 220810.0 True False 187924.32145206098 231579.17449915264 214307.55840425158 231799.40327215462 207809.14669006199 223273.69193341394 232952.38757551368 207970.40363854513 224444.82613865397 214434.6415667211 0.8763710941433338 1.0799522540162758 0.9994073571250381 1.0809792745172215 0.9691024974871068 1.0412202538830115 1.086356131049986 0.9698545072710901 1.0466817511330986 1.0 17.710178464091783 -4.749794811580943 24.99697208566096 1.0302369390564228 0.8763707525382958 0.5448598307821675 0.04223153803185826 388.2398350096875 833368.5983696228 0.009829975311711956 0.15441019553363122 1.779119781184353e-05 4.749794811580943 -0.153866186518127 QSFTMVADTPENLR ddPTM_A459_Selumetinib_30min_R1 1 QSFTMVADTPENLR 14 0 Q14847;Q14847-2;C9J9W2;F6S2S5 Q14847 LASP1 LIM and SH3 domain protein 1 0 159.44 0.044083 9450800.0 1212.2 1326.7 1569.1 1648.9 1944.6 1553.9 1425.6 1378.6 837.28 1370.1 False True 1240.4419014693995 1171.3693472339025 1356.0248384493448 1360.950568686445 1768.711273347014 1538.269176828314 1318.0658442428548 1342.0350496760948 1420.803007488321 1545.9656809041492 0.8023735046588707 0.7576942759485022 0.8771377367551144 0.880323920185926 1.14408184812524 0.9950215556717055 0.8525841553429515 0.868088513382272 0.9190391643476669 1.0 10.594292577703017 -5.6018268756178955 2.2537502943082224 0.9535247294875661 0.7823112592288356 0.42471586172139864 0.08026857337527009 0.3283872660869493 3.3433213400178072 0.02590978036312893 0.05735336017490914 2.5013422821126803e-06 5.6018268756178955 -0.17121347025873046 QSGDGQES(ph)TEPVENK ddPTM_A459_Selumetinib_30min_R1 1 QSGDGQESTEPVENK 15 0 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 QS(0.001)GDGQES(0.5)T(0.5)EPVENK 186.08 2.2043e-05 16424000.0 3958.4 4729.3 2525.3 2168.9 2988.6 2706.1 4394.8 4043.5 1963.4 4511.7 True False 4050.6230182943973 4175.591357408078 2182.3781304799772 1790.1423302953665 2718.2816576801865 2678.8790909422114 4063.296697726221 3936.25324486094 3331.746398937714 5090.820642679547 0.7956719166916785 0.8202196955047822 0.4286888664243503 0.3516412099235002 0.5339574596070277 0.5262175352404846 0.7981614326894672 0.7732060351647152 0.6544615559632156 1.0 12.313682522828163 -7.266663620737976 24.069974914121854 0.787557780668816 0.5683498746498047 0.3364657539786896 0.15738623005469699 367.9721291382259 1695368.5515139853 0.07042730379532115 0.04914580835480506 5.411733220576583e-08 7.266663620737976 -0.2192079060190113 QSGDGQES(ph)TEPVENK ddPTM_A459_Selumetinib_30min_R2 1 QSGDGQESTEPVENK 15 0 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 QS(0.067)GDGQES(0.466)T(0.466)EPVENK 134.02 0.00048692 42969000.0 70127.0 53200.0 61111.0 57279.0 70977.0 51749.0 75514.0 76737.0 67489.0 49631.0 True False 66229.62208062348 57280.26893503854 57179.184792625914 49477.50138821367 62060.234717569256 58876.95501934969 79025.5506281522 76960.29196550584 80988.68580021526 48198.02407317563 1.3741148803127647 1.1884360414458897 1.1863387740919593 1.0265462607574016 1.2876095215718308 1.2215636668001368 1.639601459764685 1.5967520130838249 1.6803320749675528 1.0 15.556686382472265 -7.245320800431913 22.197251324925936 1.5289006766447824 1.2064888803446205 0.29012582559878497 0.1968612296550612 188.21785698197567 259198.98975822274 0.07163453819703755 0.05522610363881812 5.684328912375996e-08 7.245320800431913 -0.3224117963001618 QSGLSSLVNGKS(ph)PIR ddPTM_A459_Selumetinib_30min_R1 1 QSGLSSLVNGKSPIR 15 1 H0Y612;Q9UPN9-2;Q9UPN9 H0Y612 TRIM33 E3 ubiquitin-protein ligase TRIM33 1 QS(0.001)GLS(0.064)S(0.463)LVNGKS(0.471)PIR 135.69 0.0019402 15373000.0 1381.9 1533.5 1708.6 1644.6 1720.1 1794.0 1387.4 1593.3 1174.6 1431.6 True False 1414.0955812906805 1353.9571070951913 1476.581504667995 1357.4014829654484 1564.517258708321 1775.9539888216714 1282.7473009978517 1551.0405082322095 1993.2104106102865 1615.3598049648779 0.8754059479159979 0.8381767968558744 0.9140883041224984 0.8403090622865671 0.9685255593829374 1.0994169740779733 0.7940938588760675 0.9601826809513396 1.2339111103817666 1.0 10.65763983101989 -6.860825963028173 0.4870229621777799 1.0613930289542701 0.8428515761994569 0.30236271148709304 0.10615092987909455 1.4727025093328123 0.7465110733562356 0.10221376496549953 0.12860883780383348 1.37776147544041e-07 6.860825963028173 -0.21854145275481318 QSGLSSLVNGKS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 1 QSGLSSLVNGKSPIR 15 1 H0Y612;Q9UPN9-2;Q9UPN9 H0Y612 TRIM33 E3 ubiquitin-protein ligase TRIM33 1 QSGLSSLVNGKS(1)PIR 64.843 0.037251 29272000.0 94717.0 78197.0 92170.0 111160.0 101780.0 81609.0 69200.0 73155.0 72470.0 91520.0 True False 89453.00832219266 84194.45845701532 86239.88254710847 96019.81623830441 88993.48647525525 92849.89897725762 72417.93711719863 73367.86893853778 86966.02498098326 88877.57980248317 1.0064743945659669 0.9473081810297336 0.9703221300440833 1.0803603839314004 1.0013041159877403 1.044694277044923 0.8148054580034292 0.8254935508098515 0.9784922718896256 1.0 16.439531911234887 -7.249855360584747 24.984023576125466 0.8901556137491206 1.0068493314184197 0.375659011235167 0.06440060574120335 715.4926847680546 1543152.8153777702 0.024904063949112137 0.019122886641398038 5.625286411009071e-08 7.249855360584747 0.11669371766929915 QSHAASAAPQAS(ph)SPPDYTMAWAEYYR ddPTM_A459_Selumetinib_30min_R1 2 QSHAASAAPQASSPPDYTMAWAEYYR 26 0 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 QSHAASAAPQAS(0.5)S(0.5)PPDYTMAWAEYYR;QSHAASAAPQAS(0.5)S(0.5)PPDYTMAWAEYYR 136.49 2.6329000000000003e-09 8434700.0 1312.7199999999998 1256.93 1165.8899999999999 1804.54 1540.69 1340.69 1384.58 1281.08 628.8 1015.96 True False 1343.3038218915267 1109.7680512690968 1007.5685417753532 1489.4109644110856 1401.334861530913 1327.2038758491228 1280.140015868246 1247.1015968656984 1067.0276742650683 1146.3683622884314 1.1717907315672633 0.9680728182813145 0.8789221465986728 1.2992429077838972 1.2224123655449686 1.15774642733484 1.1166916830404965 1.0878716108111872 0.9307895344695489 1.0 10.162854984127558 -8.158774044120403 4.772691423016711 0.9666573928210338 1.1134072257096619 0.2125128691764846 0.11424393560425901 0.3820983708091137 13.468068480892864 0.0910561811691612 0.032142250140748146 6.937866772949822e-09 8.158774044120403 0.14674983288862808 QSHAASAAPQASS(ph)PPDYTMAWAEYYR ddPTM_A459_Selumetinib_30min_R1 2 QSHAASAAPQASSPPDYTMAWAEYYR 26 0 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 QSHAASAAPQAS(0.287)S(0.713)PPDYTMAWAEYYR;QSHAASAAPQAS(0.345)S(0.655)PPDYTMAWAEYYR 153.25 1.4433e-11 20739900.0 1510.17 1689.8200000000002 1666.1799999999998 1708.99 2084.16 1695.69 1848.08 1864.3 722.12 1420.87 True False 1545.3540227207088 1491.9750888239955 1439.9219076716129 1410.5469782154457 1895.6480959883334 1678.6328981633346 1708.6778377022558 1814.8527079001474 1225.3848984419392 1603.2525049458263 0.9638868599634131 0.9305927071508984 0.8981254688389011 0.879803383349841 1.1823765065955016 1.0470171685277083 1.0657571607910832 1.131981832120369 0.7643118564678898 1.0 10.646785945927984 -6.21900210117239 24.999678371585517 1.0409546291134915 0.9175673671497705 0.21565073655720757 0.10548261338341565 712.0641031513538 419474.6104511861 0.030544962928639972 0.03943300747190768 6.03945707402539e-07 6.21900210117239 -0.12338726196372096 QSHAASAAPQASS(ph)PPDYTMAWAEYYR ddPTM_A459_Selumetinib_30min_R2 1 QSHAASAAPQASSPPDYTMAWAEYYR 26 0 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 QSHAASAAPQAS(0.214)S(0.786)PPDYTMAWAEYYR 127.95 4.4518e-09 8000800.0 46186.0 40271.0 48666.0 60202.0 56310.0 35127.0 37330.0 45259.0 40016.0 44828.0 True False 43619.167017206986 43359.65620832587 45534.882543534426 52002.38374575744 49235.83438221291 39965.42539884244 39065.9189679917 45390.69619696921 48020.31814045859 43533.6991628683 1.0019632573381585 0.9960021096784974 1.0459686040733478 1.1945317017790307 1.1309820972945988 0.9180342164198766 0.8973719146135104 1.0426565412498834 1.1030608256101773 1.0 15.409844994142993 -6.755440917951371 24.999939500255007 0.9889624342604145 1.074713644146946 0.21893393615323442 0.07699343800208633 255.39535343857833 1064417.9886745715 0.029023760064734283 0.028298649161165326 1.7561397857422854e-07 6.755440917951371 0.08575120988653151 QSHS(ph)ESPSLQSK ddPTM_A459_Selumetinib_30min_R1 1 QSHSESPSLQSK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QS(0.006)HS(0.687)ES(0.248)PS(0.059)LQSK 159.58 0.0004647 65188000.0 1972.5 1693.0 2160.9 2228.0 2164.0 1891.1 2323.3 2045.3 1054.2 1573.2 True False 2018.4554121831309 1494.7827729456533 1867.4616489740556 1838.9216247397658 1968.2665820852314 1872.0772509814171 2148.0516105004403 1991.0519999292878 1788.9004042783633 1775.1355442656782 1.1370711485686051 0.8420668369659633 1.0520107351839265 1.0359330760291177 1.1087979103586965 1.0546108757885533 1.2100775162997632 1.1216337852966196 1.0077542585731836 1.0 10.793713473546417 -5.856940507329465 2.0496571850037606 1.0940477123639007 0.9878038549695075 0.11262155267894924 0.08889352976013076 0.5186779524241396 4.444203145068443 0.02671713783720032 0.04774493746309059 1.3901430496080452e-06 5.856940507329465 -0.10624385739439324 QSHSES(ph)PSLQSK ddPTM_A459_Selumetinib_30min_R1 5 QSHSESPSLQSK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QSHSES(0.988)PS(0.012)LQSK;QSHSES(0.985)PS(0.015)LQSK;QSHSES(0.848)PS(0.152)LQSK;QSHS(0.001)ES(0.975)PS(0.024)LQSK;QS(0.001)HS(0.008)ES(0.967)PS(0.024)LQSK 265.64 5.7452e-26 1009240000.0 47117.7 44259.1 52499.8 52955.2 52741.9 43080.2 51374.5 48269.7 25366.4 39459.0 True False 48215.45073491563 39077.22399650263 45370.615520759005 43707.568412216904 47971.404457338715 42646.85230169198 47499.28010315275 46989.43075391718 43044.92811144629 44523.947013208395 1.0829105227488505 0.8776675613442368 1.019016025405372 0.9816642805556006 1.0774292863817219 0.9578407837256755 1.0668254566258848 1.0553743301324425 0.9667814962289092 1.0 15.442293871689685 QSHSES(ph)PSLQSK ddPTM_A459_Selumetinib_30min_R2 7 QSHSESPSLQSK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QSHS(0.002)ES(0.997)PSLQSK;QSHSES(0.997)PS(0.003)LQSK;QSHSES(0.766)PS(0.234)LQSK;QSHSES(0.723)PS(0.277)LQSK;QS(0.005)HS(0.002)ES(0.741)PS(0.253)LQSK;QS(0.011)HS(0.046)ES(0.729)PS(0.213)LQS(0.001)K;QS(0.002)HS(0.001)ES(0.672)PS(0.312)LQS(0.014)K 152.68 0.00032364 1066132400.0 563489.5 515777.5 598927.1 672831.2 690029.9 512035.8 517451.5 533257.6 494898.1 559097.7 True False 532173.0094171929 555335.9757639437 560392.7824485217 581190.4298614395 603342.1750164261 582564.0836517949 541514.0200606954 534809.2913304514 593891.5486082674 542955.0966907209 0.9801418435166294 1.022802767942844 1.0321162576133505 1.070420801653324 1.1112192862609835 1.0729507600213875 0.9973458640708802 0.9849972761837623 1.0938133783585442 1.0 19.05047336406806 -4.8302124301828195 1.7810532394097685 1.0476141735129787 0.9628761505893008 0.1984082894099627 0.04028716373170384 1.4079191785736165 4.971559119380706 0.011968883022210927 0.19769889051075362 1.4783850761173311e-05 4.8302124301828195 -0.08473802292367794 QSHSESPS(ph)LQSK ddPTM_A459_Selumetinib_30min_R1 1 QSHSESPSLQSK 12 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QS(0.003)HS(0.001)ES(0.116)PS(0.879)LQS(0.001)K 88.311 0.018073 341880000.0 5513.8 5158.3 6395.0 6723.1 6680.2 5863.9 6234.6 5099.6 3528.6 5613.5 True False 5642.260812012848 4554.363837971388 5526.594125220546 5549.036793217197 6075.977089485101 5804.914489995203 5764.319102494743 4964.342042164671 5987.776481252736 6334.047405120387 0.8907828519647161 0.7190290104696219 0.8725217497982248 0.8760649294685425 0.959256649164535 0.9164621163558963 0.9100530409410764 0.7837551133816177 0.9453318073389017 1.0 12.628911949451014 -1.5228986188744416 0.025808876589967878 1.5228943915744566 1.2710519787212558e-08 0.29531642944009595 0.06610311695825587 2560.9780126171436 5.099151610756442 102.28141502875602 218.92906345849502 0.029998627212164224 1.5228986188744416 -1.5228943788639369 QSHSGSIS(ph)PYPK ddPTM_A459_Selumetinib_30min_R1 6 QSHSGSISPYPK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QSHSGS(0.005)IS(0.995)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK 184.87 3.529e-05 830952500.0 45636.6 48137.8 39802.399999999994 41926.4 44877.0 41627.4 49897.8 46336.299999999996 23730.0 40077.3 True False 46699.84398663455 42501.80399734394 34397.45269893325 34604.7412960006 40817.88327367786 41208.66615065513 46133.96877305076 45107.31080248544 40268.07682937354 45221.61184096042 1.0326886213360311 0.939856017225088 0.7606418988315902 0.7652257380321112 0.9026189384232919 0.9112604454609361 1.0201752413270673 0.9974724244930286 0.8904608922608082 1.0 15.464724794759581 -6.962530046391204 2.9090456992685736 0.9763142344015637 0.8702437560012741 0.2342997280183715 0.0811903847239735 0.40895970239348955 7.05778159830316 0.03508578024319219 0.02903236552692484 1.0901090712641414e-07 6.962530046391204 -0.1060704784002896 QSHSGSIS(ph)PYPK ddPTM_A459_Selumetinib_30min_R2 6 QSHSGSISPYPK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK;QSHSGSIS(1)PYPK 154.47 0.00029197 1872019000.0 1718545.0 1432528.0 1750508.0 1960073.0 1951760.0 1498744.0 1748388.0 1680539.0 1449435.0 1673856.0 True False 1623035.148780714 1542398.29129648 1637882.2210890013 1693107.6760854747 1706562.4598442179 1705182.3817565623 1829691.506365099 1685429.0902617907 1739362.5005976483 1625527.4280798167 0.9984667872986636 0.9488602066336497 1.0076004826469025 1.04157435109261 1.0498515314873065 1.0490025282260782 1.1255986670901361 1.0368506007017881 1.0700296227251616 1.0 20.632476468644285 -5.702688998966817 1.9796832360850185 1.0600457610568002 0.9727923536289405 0.5053831561718849 0.0319047434787662 0.24314120236059003 1.934293986514689 0.00939686786073651 0.019814743195813708 1.9829465180699773e-06 5.702688998966817 -0.0872534074278597 QSIS(ph)FSGLPSGR ddPTM_A459_Selumetinib_30min_R2 1 QSISFSGLPSGR 12 0 M0QY76;P26651 M0QY76 ZFP36 Tristetraprolin 1 QS(0.001)IS(0.995)FS(0.004)GLPSGR 84.62 0.032379000000000005 3667500.0 10650.0 9932.6 13619.0 11964.0 13931.0 9772.0 9852.6 12048.0 9416.4 9975.6 True False 10058.115635327898 10694.398481657217 12742.768367246035 10334.482560948833 12180.86323527983 11118.004298616115 10310.765422556522 12083.057685346228 11299.943116198869 9687.578508278511 1.0382486837895295 1.1039289614549528 1.3153718812556423 1.0667766513703616 1.2573692409171895 1.147655659163457 1.0643284504735075 1.2472732659684422 1.1664362881335633 1.0 13.2419203816055 -9.854578667249747 14.347645002374628 0.999999999999928 1.1595550399465733 0.22109093026515536 0.08787227398049838 0.0 0.0 0.08259915130224965 0.02003323678856176 1.3977237114622793e-10 9.854578667249747 0.15955503994664533 QSLS(ph)PMSQRPVLK ddPTM_A459_Selumetinib_30min_R1 1 QSLSPMSQRPVLK 13 1 Q9NSV4-1;Q9NSV4-7;Q9NSV4-6;Q9NSV4-5;Q9NSV4-4;Q9NSV4 Q9NSV4-1 DIAPH3 Protein diaphanous homolog 3 1 QS(0.104)LS(0.833)PMS(0.062)QRPVLK 134.37 0.0058305 17685000.0 1518.6 1734.0 1738.5 1729.5 1987.8 1454.8 1487.0 1488.0 844.88 1198.7 True False 1553.9804253187829 1530.9824738852694 1502.4212488969383 1427.4752917358276 1808.0038409745946 1440.1660328527132 1374.834392809432 1448.533406294813 1433.6996524062836 1352.5648213267662 1.1489138271350594 1.1319106114141642 1.110794266720004 1.055384015041571 1.3367225085752832 1.0647667380850676 1.016464698128716 1.0709530393330122 1.0599859095846735 1.0 10.401482021165737 -6.976207221720596 24.999995374662472 1.0424566985343904 1.1525376918822665 0.4023041324726757 0.07010098146875485 253.34707008458358 266200.8138796908 0.024710500841907325 0.02179161259481329 1.0563133736244151e-07 6.976207221720596 0.11008099334787613 QSLSS(ph)ADNLESDAQGHQVAAR ddPTM_A459_Selumetinib_30min_R2 1 QSLSSADNLESDAQGHQVAAR 21 0 Q9Y6D5 Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 1 QS(0.02)LS(0.137)S(0.843)ADNLESDAQGHQVAAR 59.673 0.014524 6478600.0 33912.0 25280.0 26955.0 33719.0 26243.0 27215.0 24401.0 18759.0 28589.0 30018.0 True False 32027.306800492006 27218.894711988247 25220.744646384963 29126.414031480577 22946.11972460332 30963.619216827406 25535.694849664225 18813.585584280376 34307.5988434019 29151.302343869498 1.0986578377424476 0.9337111045988092 0.86516699490405 0.9991462366896909 0.7871387512616181 1.0621693278598594 0.8759709788758158 0.6453771897514164 1.1768804850880623 1.0 14.831272717282992 -4.768259968574294 4.492006114490073 0.9135876218713086 1.1130867608476185 0.11267301646673877 0.1406743411412355 0.3983002423312506 17.720093840391932 0.033143541023493796 0.25536114335994764 1.7050614340901854e-05 4.768259968574294 0.1994991389763099 QSLTS(ph)PDSQSAR ddPTM_A459_Selumetinib_30min_R2 1 QSLTSPDSQSAR 12 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 QS(0.016)LT(0.093)S(0.886)PDS(0.003)QS(0.001)AR 92.269 0.021899 3367000.0 18862.0 15898.0 24022.0 19322.0 24540.0 23013.0 21907.0 20771.0 17523.0 19019.0 True False 17813.725550568524 17117.325479872972 22476.45067317603 16690.310267690853 21457.065809616477 26182.83185878558 22925.718907896964 20831.440171175836 21028.08963352798 18469.87205270351 0.9644747673258005 0.9267701168166695 1.2169250880049307 0.9036505623896741 1.1617333216163628 1.4175968184334602 1.2412494706232269 1.127860556463717 1.1385075962369762 1.0 14.172886251848713 -5.255118408847335 24.813499574034978 1.1598093212871101 0.9456224140451049 0.2825181952995507 0.13026682227247324 590.8153632244284 2319278.0419330164 0.03552337226986124 0.0891775017851384 5.557527126099197e-06 5.255118408847335 -0.21418690724200518 QSMAFSILNT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 QSMAFSILNTPK 12 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 QSMAFS(0.003)ILNT(0.997)PK 189.33 0.00030193 56960000.0 3422.0 2724.6 3818.7 3640.4 2899.2 2663.1 3020.6 3156.0 1781.2 3035.4 True False 3501.725941947108 2405.6025653678234 3300.1415146176228 3004.6724787713842 2636.9678718953337 2636.3116319013357 2792.7537101009866 3072.2926278672244 3022.5663062992026 3425.023157299797 1.02239482220254 0.7023609636742838 0.9635384530419854 0.8772707046863278 0.7699124212562269 0.7697208196337388 0.8153970299875941 0.897013680424089 0.8824951445531594 1.0 11.741898027131933 -8.698545819468148 1.3313690574048194 0.9986516458047396 0.8427634174934909 0.19490599002432085 0.0901612113572164 1.0837432691036688 3.8043630048698125 0.08308842286400732 0.02492069948553565 2.0019543978029192e-09 8.698545819468148 -0.1558882283112487 QSMAFSILNT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 QSMAFSILNTPK 12 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 QSMAFS(0.002)ILNT(0.998)PK;QSMAFS(0.001)ILNT(0.999)PK 165.89 0.0011525 45553000.0 260061.0 213832.0 227181.0 235734.0 230890.0 184741.0 233061.0 212633.0 150863.0 185837.0 True False 245607.85072666765 230232.22682175104 212564.42179597088 203626.62253616808 201883.53401721048 210187.39583817456 243898.7983016102 213251.72682671182 181039.81546441404 180471.4029474877 1.3609239287519304 1.2757269188445464 1.177828832293288 1.1283040925626202 1.1186455622332205 1.164657626667497 1.3514539939193477 1.181637219769175 1.0031495988153412 1.0 17.461410723768658 -1.5228787452804844 0.02435144756919486 7.236027823531343e-08 2.7777247097731506 0.4472230814746647 0.08844319860949498 2363.395976221866 4.443228487181711 176.11670990534245 361.18751543416596 0.029999999999989858 1.5228787452804844 2.7777246374128723 QSMDMS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 4 QSMDMSPIK 9 0 F5H658;Q14562 F5H658 DHX8 ATP-dependent RNA helicase DHX8 1 QSMDMS(1)PIK;QSMDMS(1)PIK;QSMDMS(1)PIK;QSMDMS(1)PIK 136.01 0.0026767 139262000.0 18368.5 18239.0 21389.0 19800.7 20711.7 16926.300000000003 19839.800000000003 19016.7 11380.6 16690.5 True False 18796.45031112083 16103.569400918941 18484.491281367038 16342.879450172655 18838.33039194764 16756.03678985076 18343.26791288539 18512.315341052814 19312.046993862958 18832.88825423743 0.998065196234125 0.8550769899723486 0.9815006085010883 0.8677840185503931 1.000288969893345 0.889722094861399 0.9740018453493517 0.9829780271163406 1.0254426582453553 1.0 14.200966651436191 -7.658701687189785 2.183378384607269 1.0084571131326059 0.930909858461911 0.2937625087270912 0.04938230279205307 0.37067284721759874 3.523561609925392 0.02859024837898903 0.013265884618588731 2.194311669935323e-08 7.658701687189785 -0.0775472546706949 QSMDMS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 6 QSMDMSPIK 9 0 F5H658;Q14562 F5H658 DHX8 ATP-dependent RNA helicase DHX8 1 QSMDMS(1)PIK;QSMDMS(1)PIK;QSMDMS(1)PIK;QSMDMS(1)PIK;QSMDMS(1)PIK;QS(0.001)MDMS(0.999)PIK 140.01 0.0023307 204621300.0 860593.0 748967.0 814831.0 1009848.0 892345.0 643165.0 863876.0 858876.0 600162.0 723278.0 True False 812764.6862867363 806410.3605915217 762405.6605809123 872304.9603150326 780240.643434484 731755.1406794346 904047.9457378188 861375.1869654234 720211.1699273783 702395.0848380725 1.1571332200795623 1.1480865655223491 1.0854370667423938 1.2419007181921418 1.1108287348200303 1.0417999164218676 1.2870932118584437 1.226339998042557 1.025364763327484 1.0 19.421923223773994 -8.371448850647795 5.962747572457542 1.0034009568829585 1.1601145616765514 0.4206589369963657 0.0703671610949811 0.23921025989068417 10.679590612673572 0.06969942723343009 0.018102509076695274 4.2515877724388225e-09 8.371448850647795 0.15671360479359286 QSNAS(ph)SDVEVEEK ddPTM_A459_Selumetinib_30min_R2 1 QSNASSDVEVEEK 13 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QSNAS(0.5)S(0.5)DVEVEEK 289.59 1.4831999999999995e-60 217360000.0 118990.0 92544.0 111100.0 113660.0 106920.0 86145.0 121010.0 123040.0 99547.0 80438.0 True False 112377.01215471045 99641.82722413905 103951.94695653392 98179.31192556354 93487.7537230723 98010.69180354943 126637.20477676594 123398.0260296316 119459.18157557557 78115.54593697707 1.4385998434341767 1.2755697477238295 1.3307459572823241 1.2568472862594309 1.1967880733816723 1.2546886874812804 1.6211524000476898 1.5796858941392797 1.5292625833013338 1.0 16.253322070225394 -7.239175817967918 24.497636918922883 1.4808323939103132 1.2872577060123611 0.11245907680704592 0.17265850236555155 907.0669253257307 998089.2993066463 0.06276047211563722 0.04856884087003356 5.7653301491851095e-08 7.239175817967918 -0.19357468789795207 QSNASS(ph)DVEVEEK ddPTM_A459_Selumetinib_30min_R1 4 QSNASSDVEVEEK 13 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QSNAS(0.411)S(0.589)DVEVEEK;QSNAS(0.063)S(0.937)DVEVEEK;QSNAS(0.023)S(0.977)DVEVEEK;QSNAS(0.026)S(0.974)DVEVEEK 252.12 4.6498999999999995e-23 330472000.0 25388.3 31911.4 25851.6 25003.2 22963.9 24465.3 29998.0 29178.1 15355.1 28386.1 True False 25979.79799296778 28175.198452792614 22341.094712674196 20636.8604881927 20886.81929960583 24219.20129471507 27735.226708471637 28404.202004173847 26056.48320786822 32029.73243902874 0.8111150488822373 0.8796576276878506 0.6975111251772811 0.6443032431656018 0.6521072050591004 0.7561474745634649 0.8659212736562176 0.8868073455887778 0.8135092373147014 1.0 14.967124126132273 -7.263628118334016 3.7559204773428028 0.8851770116333818 0.7347373043835191 0.47320305859261336 0.07853101757525498 0.24294159697939496 7.738976645628194 0.03694219577446726 0.02576954724578717 5.4496910425292436e-08 7.263628118334016 -0.15043970724986266 QSNASS(ph)DVEVEEK ddPTM_A459_Selumetinib_30min_R2 3 QSNASSDVEVEEK 13 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QSNAS(0.08)S(0.92)DVEVEEK;QSNAS(0.081)S(0.919)DVEVEEK;QSNAS(0.077)S(0.923)DVEVEEK 278.89 1.8376e-48 558230000.0 709110.0 530950.0 638480.0 635590.0 626310.0 546130.0 743340.0 740170.0 598970.0 542380.0 True False 669700.5049922415 571672.1577266675 597400.8919244616 549021.545546094 547627.3385175597 621354.4502254617 777906.782900266 742323.7721582602 718780.7366201128 526720.0801275203 1.2714542890221792 1.0853433907214325 1.134190463708597 1.0423402605292253 1.0396933004433355 1.17966729135337 1.4768884123649373 1.4093325851153078 1.3646351520262796 1.0 19.006676934779613 -7.058536702352702 6.597391806203049 1.345751076541336 1.1098175163566883 0.3183989636807655 0.13341458733902528 0.2323877264020839 21.243621724631787 0.04885968715584982 0.03811178593698625 8.739031356621874e-08 7.058536702352702 -0.23593356018464773 QSNASS(ph)DVEVEEKETSVSK ddPTM_A459_Selumetinib_30min_R1 2 QSNASSDVEVEEKETSVSK 19 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QS(0.017)NAS(0.214)S(0.768)DVEVEEKETSVSK;QS(0.007)NAS(0.173)S(0.82)DVEVEEKETSVSK 91.733 0.0013235 150531000.0 5812.0 5048.7 5069.9 5019.5 5246.8 5504.4 5936.200000000001 6563.3 3399.3 5931.200000000001 True False 5947.408291816655 4457.595856923045 4381.435426967261 4142.938552684588 4772.227866397776 5449.030733595326 5488.427654737961 6389.2199633970085 5768.363824951091 6692.527294780444 0.8886640322640278 0.6660556857795051 0.6546757650707495 0.6190394704726419 0.713068121533053 0.8141962660122535 0.8200829691077136 0.9546797019983785 0.8619111392268635 1.0 12.708335402422662 -7.283479720442105 1.264201449593251 0.9384087542656603 0.6978065542762681 0.6112981882029116 0.07776598442641389 0.3159251788113059 0.9807851487414182 0.051488531368918594 0.029074248879021332 5.206193187653093e-08 7.283479720442105 -0.24060219998939214 QSNASS(ph)DVEVEEKETSVSK ddPTM_A459_Selumetinib_30min_R2 1 QSNASSDVEVEEKETSVSK 19 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QS(0.009)NAS(0.155)S(0.836)DVEVEEKETSVSK 95.122 0.00096508 106680000.0 195860.0 171690.0 192830.0 186420.0 166440.0 158630.0 161220.0 175880.0 138480.0 179770.0 True False 184974.8852897016 184858.07092963846 180423.52773742948 161029.27440756292 145530.319207521 180479.8426002328 168717.04945136933 176391.78168149845 166179.86945448586 174579.57300144594 1.0595448374029965 1.0588757192578733 1.0334744474139317 0.9223832527430297 0.8336045088523367 1.0337970215950636 0.9664191895461444 1.0103804164994579 0.951886103267703 1.0 17.413525238137623 -5.62270948545625 5.471876409203284 0.9585921429722666 1.0561267846958682 0.3942097471590751 0.05212827125908157 0.21581716099276962 9.767923771776069 0.01509707777954955 0.02660318557673102 2.38391361807214e-06 5.62270948545625 0.0975346417236016 QSNASS(ph)DVEVEEKETSVSKEDTDHEEK ddPTM_A459_Selumetinib_30min_R2 1 QSNASSDVEVEEKETSVSKEDTDHEEK 27 2 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QS(0.013)NAS(0.309)S(0.632)DVEVEEKET(0.02)S(0.02)VS(0.003)KEDT(0.002)DHEEK 40.717 0.036334 11856000.0 35942.0 39532.0 33091.0 29626.0 22649.0 13598.0 12151.0 16582.0 7985.2 30265.0 True False 33944.48752722584 42563.97728458541 30961.96108675666 25590.887692299413 19803.630135370986 15471.001069646116 12716.04557674973 16630.250874702117 9582.463125129689 29391.17081208641 1.1549212429899864 1.4481892387588045 1.0534442906243224 0.8706998389385624 0.6737952108810589 0.5263826054620472 0.43264848678707835 0.565824715899488 0.3260320314013871 1.0 14.843095210166693 -5.898276778714904 1.3423339498024112 0.5368236953145079 1.3125606969410804 0.7118239409301913 0.18285853226969057 0.21064307268946544 0.7692497625550203 0.06063987460315465 0.12495044064531592 1.263930579509612e-06 5.898276778714904 0.7757370016265724 QSNVAAPGDAT(ph)PPAEK ddPTM_A459_Selumetinib_30min_R2 1 QSNVAAPGDATPPAEK 16 0 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 1 QSNVAAPGDAT(1)PPAEK 169.72 2.5429e-05 7531600.0 67447.0 55318.0 57908.0 69624.0 68792.0 63336.0 66018.0 70208.0 61756.0 53649.0 True False 63698.565751733375 59560.71272459513 54182.262325463256 60141.09109190084 60149.73395171702 72059.95909303636 69087.96781218523 70412.29365643984 74108.92560681139 52100.01397315788 1.222620895736249 1.1431995537521549 1.0399663684040115 1.1543392507127876 1.1545051404920232 1.38310824887997 1.3260642856598772 1.3514832009971536 1.422435810573728 1.0 15.668996138982271 -6.696313998014248 7.13583623830336 1.3201677557399762 1.136595640687777 0.2934657480628151 0.11630077648026528 0.23518715451782646 21.214871796256375 0.03655521750397657 0.03637938595414648 2.012268839037592e-07 6.696313998014248 -0.18357211505219917 QSNVAAPGDAT(ph)PPAEKK ddPTM_A459_Selumetinib_30min_R1 1 QSNVAAPGDATPPAEKK 17 1 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 1 QSNVAAPGDAT(1)PPAEKK 98.002 0.006695399999999999 3763100.0 1848.4 1971.1 3002.3 2701.8 2782.1 2141.8 2353.6 2320.0 1273.2 1994.3 True False 1891.4641236396935 1740.3226956604708 2594.604150453424 2229.981349067279 2530.4595462196503 2120.2554365988053 2176.066057105769 2258.466063577935 2160.527409151215 2250.28783112703 0.8405431951753372 0.7733778193116081 1.1530099014728916 0.9909760512504835 1.1245048349891753 0.9422152167693589 0.967016764258069 1.003634305059904 0.9601115818455723 1.0 11.135893830984962 -5.242585995012872 24.91299343587391 1.0161697578064566 0.8069604665904736 0.6132290702073269 0.06693165012944648 508.7082077630162 672208.0883830022 0.01689236739826139 0.04453464751034426 5.720236765518823e-06 5.242585995012872 -0.20920929121598297 QSPAS(ph)PPPLGGGAPVR ddPTM_A459_Selumetinib_30min_R2 1 QSPASPPPLGGGAPVR 16 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 QS(0.02)PAS(0.98)PPPLGGGAPVR 122.5 0.0014405 43229000.0 47629.0 31596.0 43682.0 50517.0 43050.0 23527.0 50589.0 38520.0 34580.0 34519.0 True False 44981.97085399364 34019.31160284731 40871.54767736557 43636.49745331428 37641.67412811694 26767.630693158135 52941.48874020179 38632.086822670724 41496.966245928044 33522.346778867024 1.3418502932005623 1.0148248816605399 1.2192328880486252 1.3017136819556847 1.1228830241636543 0.7985010974838086 1.579289453970355 1.1524278737855238 1.2378896537186452 1.0 15.032835530010368 -7.266317000624918 24.99822587747885 1.255104026475714 1.1388941911763601 0.06705939879579959 0.19664325835762173 1221.0277696000803 6257842.2603687635 0.07903755581665978 0.055128964156434285 5.4160541696635935e-08 7.266317000624918 -0.11620983529935391 QSPDHPT(ph)VGAGVLHITENGPTEVDYSPSDMQDSSLSHK ddPTM_A459_Selumetinib_30min_R1 4 QSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 38 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QS(0.02)PDHPT(0.978)VGAGVLHIT(0.001)ENGPT(0.001)EVDYSPSDMQDSSLSHK;QS(0.139)PDHPT(0.845)VGAGVLHIT(0.005)ENGPT(0.011)EVDYSPSDMQDSSLSHK;QS(0.003)PDHPT(0.992)VGAGVLHIT(0.003)ENGPT(0.001)EVDYSPSDMQDSSLSHK;QS(0.162)PDHPT(0.826)VGAGVLHIT(0.005)ENGPT(0.005)EVDY(0.001)SPSDMQDSSLSHK 133.29 2.3434e-30 143829000.0 10192.800000000001 11193.9 7259.4400000000005 8351.800000000001 15763.900000000001 9922.439999999999 15204.199999999999 10531.52 2167.48 6611.200000000001 True False 10430.272408263734 9883.312984097078 6273.647921249579 6893.314912702683 14338.058028342592 9822.62926245469 14057.334953028354 10252.189878401845 3678.05525352425 7459.811918541358 1.398195091532978 1.3248742853063238 0.8409927743159892 0.9240601489655996 1.922040151267803 1.3167395330759681 1.8844087634553972 1.3743228368693898 0.49304932801086393 1.0 12.864923541468567 -8.245703276284521 23.506107772167663 0.7465247446110536 1.372333951963844 0.34705462344846116 0.34382929982014865 377.7308335233339 564246.9937324657 0.24763916976976957 0.09274103761195099 5.679325023162653e-09 8.245703276284521 0.6258092073527904 QSPDHPT(ph)VGAGVLHITENGPTEVDYSPSDMQDSSLSHK ddPTM_A459_Selumetinib_30min_R2 5 QSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 38 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QS(0.177)PDHPT(0.77)VGAGVLHIT(0.027)ENGPT(0.008)EVDY(0.014)S(0.004)PSDMQDSSLSHK;QS(0.34)PDHPT(0.645)VGAGVLHIT(0.008)ENGPT(0.008)EVDYSPSDMQDSSLSHK;QS(0.138)PDHPT(0.862)VGAGVLHITENGPTEVDYSPSDMQDSSLSHK;QS(0.439)PDHPT(0.547)VGAGVLHIT(0.011)ENGPT(0.003)EVDYSPSDMQDSSLSHK;QS(0.101)PDHPT(0.813)VGAGVLHIT(0.039)ENGPT(0.039)EVDY(0.005)S(0.002)PSDMQDSSLSHK 118.37 2.3983e-23 466778000.0 153636.9 120366.5 210995.4 317637.0 312262.0 211342.6 146520.4 177851.2 185710.3 252077.9 True False 145098.37615524023 129598.22351070128 197420.18567842158 274374.29264561215 273032.8559023008 240453.12477289257 153333.88892466473 178368.71754714876 222857.54917932785 244799.7560499598 0.5927227154819056 0.5294050353720626 0.8064558105120464 1.1208111358967885 1.1153314051774588 0.9822441355857391 0.6263645495356281 0.7286311082383043 0.9103667126769771 1.0 17.90124259478074 -5.389369420152741 4.1913914037668665 0.9155969821857683 0.5632679379403017 0.4876557574686232 0.1470781143443637 0.21796110741657837 6.290484700994913 0.04529237593480036 0.10036462397990686 4.079722088296967e-06 5.389369420152741 -0.3523290442454666 QSPDHPTVGAGVLHIT(ph)ENGPTEVDYSPSDMQDSSLSHK ddPTM_A459_Selumetinib_30min_R2 1 QSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 38 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 QS(0.013)PDHPT(0.115)VGAGVLHIT(0.395)ENGPT(0.395)EVDY(0.033)S(0.042)PS(0.005)DMQDS(0.001)SLSHK 50.627 0.045452 14921000.0 9371.9 8740.0 16739.0 21869.0 22855.0 14557.0 9869.4 12353.0 11569.0 23042.0 True False 8851.047316688215 9410.32989647062 15662.030964045196 18890.404473870778 19983.750573707606 16562.09461471088 10328.346655845091 12388.945184850756 13883.123264868189 22376.717589694214 0.3955471700087344 0.42054112086594087 0.6999253085831711 0.8441990831832688 0.8930599625975211 0.7401485293061344 0.4615666535739763 0.5536533736546145 0.620427156450425 1.0 14.449710804408143 -5.258177180942741 5.410151836080077 0.7126441033644881 0.4036352677837196 0.4119447383161714 0.1516937838286135 0.1753574800447873 18.85565278466859 0.042878438595713574 0.10535692881507684 5.518522518689496e-06 5.258177180942741 -0.3090088355807685 QSPGST(ph)SPKPPHTLSR ddPTM_A459_Selumetinib_30min_R2 1 QSPGSTSPKPPHTLSR 16 1 E9PPY3;O43159 E9PPY3 RRP8 Ribosomal RNA-processing protein 8 1 QS(0.001)PGS(0.158)T(0.502)S(0.339)PKPPHTLSR 70.11399999999999 0.024654 36059000.0 67571.0 55249.0 80359.0 85124.0 86184.0 66512.0 62584.0 67301.0 61855.0 68204.0 True False 63815.67432814482 59486.42064646512 75188.78942826379 73529.96435290943 75356.79542526438 75673.42426417884 65494.28000784339 67496.83476771975 74227.72837310226 66234.77330472642 0.9634769041111978 0.8981146560702467 1.1351860310949147 1.1101414058536898 1.1377225536587898 1.142502955600497 0.9888201731517032 1.0190543637431497 1.1206761142157555 1.0 16.015301211431655 -5.257300436521917 24.99740268578126 1.0843054380883974 0.9307957693334741 0.5213010886134417 0.057825739759528864 276.35915529945703 1669072.6748516422 0.015625149148065766 0.03836978839429393 5.529674446889862e-06 5.257300436521917 -0.15350966875492333 QSPLT(ph)YEDHGAPFAGHLPR ddPTM_A459_Selumetinib_30min_R2 1 QSPLTYEDHGAPFAGHLPR 19 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 QS(0.054)PLT(0.922)Y(0.023)EDHGAPFAGHLPR 127.07 0.00048261 13766000.0 20889.0 19986.0 20371.0 21670.0 27499.0 14926.0 14632.0 16223.0 13927.0 19572.0 True False 19728.073005292434 21518.8619348812 19060.352038267796 18718.508617164927 24044.329775820854 16981.92101526239 15312.416992757948 16270.206244137773 16712.789152893016 19006.90550583696 1.037942394106921 1.1321601997901671 1.0028119533931719 0.984826731075005 1.2650312681586657 0.8934605904179034 0.8056238817021295 0.8560155275745042 0.8793009018622506 1.0 14.214236047002174 -6.963806138860726 24.629169729880118 0.8698514725845186 1.07733062994159 0.5619712923454875 0.08674318221464691 103.02103149647712 70103.30537740864 0.029724045286073763 0.02621405943874141 1.0869106924641503e-07 6.963806138860726 0.20747915735707134 QSPNS(ph)SSAAASVASR ddPTM_A459_Selumetinib_30min_R1 1 QSPNSSSAAASVASR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 QS(0.064)PNS(0.466)S(0.327)S(0.142)AAAS(0.001)VASR 166.36 8.0126e-05 18344000.0 1254.9 1619.8 793.88 720.28 980.45 838.11 1214.4 1216.2 548.98 1112.0 True False 1284.1367283896625 1430.1530629754095 686.075456470694 594.4966193301428 891.7684706125069 829.6793743429943 1122.7968302809513 1183.9424252256397 931.5789640872092 1254.7360317972502 1.0234317783560416 1.1398039322477227 0.5467886783230238 0.4738021418565639 0.7107219749919524 0.6612381834245915 0.8948470449778088 0.9435788845003457 0.7424501572277641 1.0 10.293168170214376 -10.96403110993359 12.87670763935422 1.0000000135174074 0.7876696814129274 0.0882699467595397 0.19896334648507213 8.513743331091025e-08 3.685999034701657e-09 0.21234823583850457 0.05150200903470354 1.0863478021850997e-11 10.96403110993359 -0.21233033210448005 QSPNS(ph)SSAAASVASR ddPTM_A459_Selumetinib_30min_R2 1 QSPNSSSAAASVASR 15 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 QS(0.089)PNS(0.556)S(0.177)S(0.177)AAAS(0.001)VASR 76.24 0.037154 12595000.0 12865.0 10105.0 13338.0 15893.0 13772.0 10206.0 11780.0 13298.0 11824.0 11556.0 True False 12150.014802675438 10880.02100730384 12479.84760131637 13728.345983045785 12041.83823675788 11611.783859156378 12327.793341627174 13336.694978397582 14189.130390163487 11222.348253906175 1.0826624274867223 0.9694959344642347 1.1120531388760366 1.2233042205108315 1.0730230397694587 1.0347017929259725 1.0985039015641156 1.188405017974332 1.2643637560636796 1.0 13.454086968133748 -7.679538949120269 5.694136497541068 1.169404148112512 1.0835037799440739 0.10068835362205542 0.08602552566200478 0.38181149717193463 20.088592885568577 0.04257046696879856 0.023907562244941845 2.0915153239344364e-08 7.679538949120269 -0.08590036816843805 QSPS(ph)PSTRPIR ddPTM_A459_Selumetinib_30min_R2 1 QSPSPSTRPIR 11 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 QS(0.269)PS(0.697)PS(0.027)T(0.007)RPIR 69.345 0.038154 10013000.0 15395.0 18279.0 19696.0 16948.0 23356.0 12523.0 14630.0 15737.0 15806.0 21466.0 True False 14539.407531067885 19680.9405237513 18428.780803383364 14639.653163069275 20421.810474710775 14247.929577524514 15310.32398879503 15782.792064599398 18967.64165653959 20846.220804633962 0.6974601136257697 0.9441011254844028 0.8840346159667839 0.7022689292351249 0.9796408982759675 0.6834778212824697 0.7344412271308024 0.7571056745734459 0.9098839465579881 1.0 14.34749824184777 -8.49951768523702 4.11221996781115 0.9994306287119723 0.8030682234042926 0.3010593071017734 0.10011494412854159 0.2281137483389192 10.06406755589158 0.09543107430493715 0.024993585551857066 3.1657915441939702e-09 8.49951768523702 -0.19636240530767968 QSQQPMKPIS(ph)PVKDPVS(ph)PASQK ddPTM_A459_Selumetinib_30min_R2 2 QSQQPMKPISPVKDPVSPASQK 22 2 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 2 QSQQPMKPIS(1)PVKDPVS(0.988)PAS(0.012)QK;QS(0.034)QQPMKPIS(0.966)PVKDPVS(0.935)PAS(0.065)QK 100.28 0.0014658 18800400.0 123907.0 112745.0 105771.0 116544.0 107337.0 85697.0 132808.0 122632.0 82659.0 98793.0 True False 117020.7449790209 121392.17896768675 98965.80901475735 100670.50615038631 93852.36645504509 97500.98387008841 138983.83515405934 122988.8388171794 99193.10968542975 95940.58939495939 1.2197209305988383 1.2652848990530026 1.0315322184163787 1.0493004763182685 0.9782342077208043 1.016264174370509 1.4486447918503345 1.2819270716679703 1.033901399928665 1.0 16.549853682071685 QSQQPMKPIS(ph)PVKDPVSPASQK ddPTM_A459_Selumetinib_30min_R2 2 QSQQPMKPISPVKDPVSPASQK 22 2 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 QSQQPMKPIS(0.998)PVKDPVS(0.002)PASQK;QSQQPMKPIS(1)PVKDPVSPASQK 118.85 3.736e-05 11571800.0 125082.0 97481.0 107548.0 119571.0 105683.0 84606.0 116192.0 103646.0 79183.0 88474.0 True False 118130.4431829188 104957.47924918233 100628.47876940848 103285.22352851984 92406.1567219926 96259.70852320036 121595.15823008 103947.59270048095 95021.81255787496 85919.52573694142 1.3748963599333297 1.2215788943077868 1.1711945323988548 1.2021158478544998 1.0754965874103077 1.1203472982138813 1.4152214783210764 1.2098250288151706 1.105939677190513 1.0 16.39069840943177 -14.448657552543162 0.21698054669620867 7.510009986716256e-13 1.2360467396369066 0.30219014696714097 0.10160055687706465 210.80380987731786 2.1651131876771754 92.02759032836389 0.21389162357073652 3.5591184957489205e-15 14.448657552543162 1.2360467396361556 QSS(ph)GASSSSFSSSR ddPTM_A459_Selumetinib_30min_R1 3 QSSGASSSSFSSSR 14 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 QS(0.018)S(0.937)GAS(0.01)S(0.01)S(0.006)S(0.019)FSSSR;QS(0.01)S(0.989)GASSSSFSSSR;QS(0.001)S(0.294)GAS(0.036)S(0.294)S(0.294)S(0.08)FSSSR 178.47 7.1551e-05 8022300.0 2071.08 1961.99 2392.67 3036.3799999999997 2508.4900000000002 1721.1000000000001 1809.9199999999998 2293.43 1091.06 1471.8899999999999 True False 2119.332134379842 1732.2792986955956 2067.7585559955337 2506.1332329117295 2281.597522409881 1703.7872966337688 1673.3962772250482 2232.6007862894576 1851.449132130479 1660.8214189227122 1.2760746641589809 1.0430256251266523 1.2450216094496063 1.5089721293077536 1.3737765520207668 1.025870257465084 1.0075714692495312 1.3442750441752063 1.114779175554839 1.0 10.69768123942808 -6.76141692579952 24.999999999957016 1.1143333977541612 1.2854239494710742 0.30613334856921026 0.14262750946496652 0.9730579876419443 1081932.895538896 0.05341803995495533 0.05019657334648492 1.7321403322459276e-07 6.76141692579952 0.171090551716913 QSS(ph)GASSSSFSSSR ddPTM_A459_Selumetinib_30min_R2 3 QSSGASSSSFSSSR 14 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 QS(0.053)S(0.945)GAS(0.001)SSSFSSSR;QS(0.244)S(0.754)GAS(0.001)SSSFSSSR;QS(0.017)S(0.514)GAS(0.152)S(0.152)S(0.152)S(0.013)FSSSR 187.78 7.0347e-05 9517700.0 29847.7 32317.4 31777.8 37430.7 33562.2 21898.5 27634.6 22541.5 24159.3 31631.5 True False 28188.884323810013 34796.04066318074 29733.250945052583 32332.574088440935 29345.816386125123 24914.819600209277 28919.66365692108 22607.092033053777 28991.83506724264 30718.21640649301 0.9176601906434787 1.1327493824096437 0.9679354605616936 1.0525537570471277 0.9553229262335101 0.8110763746993771 0.9414499616197844 0.7359506728481554 0.9437994277921207 1.0 14.90680683075795 -6.536542052929319 5.402419690748611 0.8735572483310398 1.0208400296590674 0.3317961291464704 0.08684351218367739 0.1698605050011916 15.538496593511493 0.026580639499380027 0.02753351673390526 2.907086451331232e-07 6.536542052929319 0.14728278132802763 QSS(ph)LTFQSSDPEQMR ddPTM_A459_Selumetinib_30min_R2 2 QSSLTFQSSDPEQMR 15 0 A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2 A0A0X1KG75 COBLL1 Cordon-bleu protein-like 1 1 QS(0.094)S(0.888)LT(0.006)FQS(0.006)S(0.006)DPEQMR;QS(0.002)S(0.935)LT(0.063)FQSSDPEQMR 215.93 3.7637e-09 7159000.0 25431.0 18431.1 25179.0 30139.0 31594.0 12523.7 16764.3 22669.0 18411.9 16004.8 True False 24017.646828359044 19844.70610467271 23559.01055282237 26034.016207325065 27624.87926605635 14248.725996170551 17543.873167830247 22734.96303694502 22094.794471469133 15542.699838535624 1.5452686520273107 1.276786292653671 1.5157605047748264 1.6749996125369357 1.7773539702262604 0.9167471638899651 1.1287532635953657 1.4627422052234025 1.4215544725819542 1.0 13.923949507835191 -6.754749999882024 24.999696050237123 1.2113054203693272 1.5465584933050716 0.4679244857768905 0.19726779080997114 175.35170556313676 655327.5024308763 0.07163097448941934 0.07006797118604824 1.7589358479298062e-07 6.754749999882024 0.33525307293574436 QSS(ph)PSGSEQLVR ddPTM_A459_Selumetinib_30min_R2 3 QSSPSGSEQLVR 12 0 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 QS(0.01)S(0.977)PS(0.01)GS(0.003)EQLVR;QS(0.001)S(0.988)PS(0.007)GS(0.004)EQLVR;QS(0.095)S(0.892)PS(0.008)GS(0.004)EQLVR 173.33 0.00018814 48544000.0 144067.0 127970.0 133766.0 152610.0 161711.0 108605.0 124046.0 122830.0 112519.0 133850.0 True False 136060.33288589513 137784.88751159585 125159.64119340894 131824.25473306628 141395.41846531737 123564.35293196929 129814.38479248602 123187.4149643988 135025.9440435392 129985.40271593508 1.0467354798541184 1.0600027744092577 0.9628745888253917 1.0141466039932943 1.087779208364783 0.9506017625840796 0.9986843297795307 0.9477019141419107 1.0387777490570962 1.0 16.98799009298464 -6.780632455533945 24.99991791098737 0.984605232279244 1.0306466908535978 0.2650521867886966 0.03890764506762331 357.4298479316018 465566.97330934566 0.013734270008567676 0.01213199210677457 1.6571718386991398e-07 6.780632455533945 0.04604145857435382 QSS(ph)SEQCSDGEGR ddPTM_A459_Selumetinib_30min_R2 1 QSSSEQCSDGEGR 13 0 A0A3B3IRT3;O60343-2;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 QS(0.038)S(0.942)S(0.021)EQCSDGEGR 132.15 0.0016457000000000002 0.0 1315.2 502.02 730.2 1000.2 1027.0 682.59 2462.5 7027.1 1969.6 4585.2 True False 1242.1064491627462 540.5233197512788 683.2197269816472 863.9710345587613 897.9790785035095 776.6105765649179 2577.01112935118 7047.547697600967 2363.57503522209 4452.81336221968 0.27894868886747354 0.12138917034731356 0.1534355184923065 0.19402812655235138 0.2016655551123024 0.1744089665096104 0.5787377371834348 1.5827179637477191 0.5308048738974932 1.0 12.120501427760438 -7.528208462631193 5.749227396731283 1.0550971634695647 0.1962757862541181 0.7168745792666782 0.2395607923051811 0.07662566205341309 9.343570997619475 0.10284587289224087 0.06163688845221314 2.9634086032180466e-08 7.528208462631193 -0.8588213772154466 down QSS(ph)TDSSGGHPGPR ddPTM_A459_Selumetinib_30min_R1 1 QSSTDSSGGHPGPR 14 0 Q9GZV5;C9JR84;C9J038;C9JQS8 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 QS(0.145)S(0.425)T(0.425)DS(0.004)SGGHPGPR 92.096 0.010677 316870.0 149.8 174.48 120.62 214.34 0.0 122.73 0.0 0.0 0.0 127.31 True False 153.29004853994059 154.05180048644866 104.24046651823338 176.9095426601084 0.0 121.49544762992407 0.0 0.0 0.0 143.65147860441368 1.0670969072449963 1.0723996855658917 0.7256484063438703 1.2315191209919985 0.0 0.8457653816741928 0.0 0.0 0.0 1.0 7.1664290323790745 -6.259366390384313 24.99582444731022 0.26915307156904417 1.0062886155726785 0.4857148304200154 0.35971498914665134 156.36945546762576 1885479.6752234981 0.10583909788610885 0.1299137201710221 5.503432061858984e-07 6.259366390384313 0.7371355440036342 QSS(ph)TDSSGGHPGPR ddPTM_A459_Selumetinib_30min_R2 1 QSSTDSSGGHPGPR 14 0 Q9GZV5;C9JR84;C9J038;C9JQS8 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 QS(0.001)S(0.994)T(0.005)DSSGGHPGPR 174.4 8.654399999999999e-05 893350.0 1912.9 2875.7 3232.5 4748.7 3859.5 3680.6 2799.7 3638.2 4315.4 5678.9 True False 1806.5886759454208 3096.2569431671127 3024.52446927989 4101.918868035584 3374.635105632226 4187.569240839795 2929.8915975003047 3648.786559663565 5178.60058235043 5514.935401445815 0.32758111282170216 0.5614312258953 0.548424278639233 0.7437836655276524 0.6119083651909177 0.7593142867533802 0.5312648987206984 0.6616190932548343 0.9390138243492009 1.0 12.429128271737206 -6.484989336641636 0.11198511119217268 1.260270028474977 2.2399203658356524e-19 0.6713058294579188 0.10895704995981371 14.646458561559088 0.5765948949483815 2.0706671341977474 4.234723417938017 3.2734873226852346e-07 6.484989336641636 -1.260270028474977 QSS(ph)TPSAPELGQQPDVNISEWK ddPTM_A459_Selumetinib_30min_R1 2 QSSTPSAPELGQQPDVNISEWK 22 0 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L213 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 QS(0.233)S(0.415)T(0.126)PS(0.226)APELGQQPDVNISEWK;QS(0.272)S(0.536)T(0.173)PS(0.018)APELGQQPDVNISEWK 199.8 1.4858e-22 16974500.0 6637.2 7530.299999999999 8235.3 8253.2 6970.0 6897.6 7662.799999999999 6874.3 3631.4 6029.7 True False 6791.833846256966 6648.648975258507 7116.991493264857 6811.933551751456 6339.564730653443 6828.216406519713 7084.78882664433 6691.971233126641 6162.220573037797 6803.670729251695 0.9982602210680425 0.9772149828875921 1.0460517236182627 1.0012144653714996 0.9317859406977361 1.0036077109320543 1.0413185923569164 0.9835824659114067 0.9057199882622116 1.0 12.732097606620107 -8.013118271712349 24.80733770233904 0.950123729178645 0.9993977429022617 0.20423937157075844 0.03671380536059442 834.3248356298244 1577743.2202715941 0.0228534188088632 0.009518925036422052 9.702457035896216e-09 8.013118271712349 0.04927401372361673 QSS(ph)TPSAPELGQQPDVNISEWK ddPTM_A459_Selumetinib_30min_R2 2 QSSTPSAPELGQQPDVNISEWK 22 0 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L213 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 QS(0.24)S(0.389)T(0.141)PS(0.229)APELGQQPDVNISEWK;QS(0.326)S(0.489)T(0.132)PS(0.053)APELGQQPDVNISEWK 124.97 2.106e-05 5696500.0 37413.0 28598.0 34678.0 37963.0 39998.0 33415.0 36158.0 30069.0 28709.0 37367.0 True False 35333.7352361054 30791.374642936687 32446.855234551596 32792.37391017223 34973.09365334313 38017.61293883112 37839.41864571778 30156.49581180906 34451.602196482054 36288.117618874385 0.9736998652618843 0.8485249900899048 0.8941454493543405 0.90366698693448 0.9637615822528288 1.0476601001496197 1.0427495590467477 0.8310294881794555 0.9493907222832327 1.0 15.147209601085631 -6.271751818096716 5.1480880499715305 0.9716548803537421 0.8997741932579125 0.21317630198131665 0.0632865237594502 0.30577743358207005 26.219246757329383 0.020908400673968507 0.025119707738371633 5.348699288215489e-07 6.271751818096716 -0.07188068709582962 QSS(ph)VSSTASVNLGDPGSTR ddPTM_A459_Selumetinib_30min_R2 3 QSSVSSTASVNLGDPGSTR 19 0 Q96RT1-7;Q96RT1-6;Q96RT1-4;Q96RT1-5;Q96RT1-3;Q96RT1-9;Q96RT1-2;Q96RT1;Q96RT1-8 Q96RT1-7 ERBB2IP Protein LAP2 1 QS(0.198)S(0.594)VS(0.198)S(0.004)T(0.004)ASVNLGDPGSTR;QS(0.098)S(0.894)VS(0.008)STASVNLGDPGSTR;QS(0.033)S(0.478)VS(0.478)S(0.007)T(0.003)AS(0.001)VNLGDPGSTR 109.77 0.00068334 7035600.0 30938.4 23840.3 26706.0 28656.3 26864.9 16920.2 28291.4 24896.0 22680.7 24797.4 True False 29218.96758422804 25668.774351353368 24987.765035294266 24753.26250512523 23489.891086746768 19250.803963717182 29607.006158345594 24968.44323824534 27217.473751706773 24081.434630617263 1.2133399871068682 1.0659154965260231 1.0376360635725868 1.0278981665674436 0.9754357016953465 0.7994043651885095 1.229453585821797 1.0368337111652115 1.1302264241808224 1.0 14.555633721515191 -4.656411975429328 2.045908937255752 1.0275352329383598 1.3135525821754042 0.2199768233240108 0.10345753082417587 1.7982643080673013 6.239472655338723 0.02820026186501275 1.0816645800697775 2.2059111941316737e-05 4.656411975429328 0.28601734923704436 QSSFEPEFVIS(ph)PRPK ddPTM_A459_Selumetinib_30min_R2 2 QSSFEPEFVISPRPK 15 1 Q9H9A7;A0A0A0MSU3 Q9H9A7 RMI1 RecQ-mediated genome instability protein 1 1 QSSFEPEFVIS(1)PRPK;QSSFEPEFVIS(1)PRPK 87.35600000000002 0.010306999999999998 30355000.0 43025.0 41283.0 47467.0 55765.0 56496.0 44369.0 46442.0 51330.0 38361.0 46677.0 True False 40633.84274272139 44449.27335423301 44413.02489816196 48169.710800009365 49398.4673993518 50480.4270083195 48601.645023077144 51479.36180186103 46034.271895894904 45329.31372858937 0.8964142494196525 0.9805856232541789 0.9797859540536238 1.0626613737950448 1.0897687023264153 1.1136375748058438 1.0721901794957884 1.1356748551300657 1.015551926762591 1.0 15.46815669899405 -5.411475963463828 1.2400089503606782 1.0811873218387449 0.9074017183970997 0.6305321179718364 0.04223692985544423 0.36550378733639227 0.9312416980014739 0.013119641855322387 0.06111385583617696 3.877252070217275e-06 5.411475963463828 -0.17378560344164518 QSSGASSSS(ph)FSSSR ddPTM_A459_Selumetinib_30min_R1 3 QSSGASSSSFSSSR 14 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 QSSGAS(0.165)S(0.066)S(0.028)S(0.74)FS(0.001)SSR;QSS(0.001)GAS(0.156)S(0.043)S(0.023)S(0.772)FS(0.005)S(0.001)SR;QSSGAS(0.183)S(0.183)S(0.059)S(0.57)FS(0.003)SSR 163.9 0.00026464 10388400.0 2840.98 2898.92 3138.31 3411.13 2907.9300000000003 3075.77 3057.42 2823.09 1599.73 2495.39 True False 2907.1693064152228 2559.513098728655 2712.1447395028777 2815.4401803404644 2644.908244936739 3044.830546375714 2826.7963478570373 2748.2124825113074 2714.624970343602 2815.6976136569606 1.0324863338714347 0.9090156152827863 0.9632230131347127 0.9999085721011917 0.9393438528726085 1.0813769673303666 1.0039417351303082 0.9760325360158241 0.9641038715154899 1.0 11.459276691541461 QSSGASSSS(ph)FSSSR ddPTM_A459_Selumetinib_30min_R2 2 QSSGASSSSFSSSR 14 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 QSSGAS(0.077)S(0.194)S(0.077)S(0.653)FSSSR;QSSGAS(0.008)S(0.011)S(0.037)S(0.944)FSSSR 173.19 0.00010872 36059000.0 47325.0 52545.0 58977.0 68438.0 52566.0 44355.0 46773.0 54727.0 51200.0 44140.0 True False 44694.86595698522 56575.032541195455 55182.48402930244 59116.626337864975 45962.18913399756 50464.49863539886 48948.037178941224 54886.2465094574 61441.43064752799 42865.56351050698 1.0426753388189998 1.3198247709336208 1.2873383553158328 1.3791169763433675 1.0722404039487676 1.17727365518079 1.1418965055001165 1.2804275043766535 1.4333517540826866 1.0 15.387531488736109 -6.257193445286867 24.934977083267132 1.1957583591798546 1.2638592344567539 0.059683357951847094 0.13650288372963598 1245.4128945832417 7313869.273916869 0.04129310861985823 0.05159141146188653 5.531036885522304e-07 6.257193445286867 0.06810087527689923 QSSGASSSSFSSS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 QSSGASSSSFSSSR 14 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 QSSGASSSS(0.001)FS(0.008)S(0.177)S(0.815)R 112.91 0.0034617 1571800.0 3221.9 3909.5 6322.1 6743.5 7452.9 3014.0 5338.9 4779.2 4153.6 6181.1 True False 3042.839696287601 4209.346078976186 5915.342968982021 5825.023666813644 6516.600072228637 3429.151141632108 5587.169428829654 4793.106680760847 4984.4360612807095 6002.635582573511 0.5069172789901472 0.7012496462714654 0.9854576190090713 0.9704110114104713 1.0856231371345009 0.5712742501955995 0.9307860442253044 0.7985003611873266 0.8303745900802679 1.0 12.551380369889515 -4.976326643881676 3.4044648339058603 0.8877369927953783 0.5155049768668711 0.4558930995359034 0.13531636360217503 0.22898929747977487 5.315812241728241 0.035488491574330754 0.17338072176018102 1.0560229488349255e-05 4.976326643881676 -0.3722320159285072 QSSGASSSSFSSSR ddPTM_A459_Selumetinib_30min_R2 1 QSSGASSSSFSSSR 14 0 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 0 127.78 0.016461 924800.0 0.0 817.39 526.81 668.11 1196.1 529.55 564.52 767.55 0.0 641.93 False True 0.0 880.0811846769012 492.91561814735906 577.112265445965 1045.835224730329 602.4907057237174 590.7712985751585 769.783443425257 0.0 623.3958129655588 0.0 1.4117534419909934 0.7906944639273532 0.9257557613365767 1.6776423629719004 0.9664657560942003 0.9476664524979691 1.234822928571363 0.0 1.0 9.284004654917489 -8.239911805939487 24.83242436019913 0.499999691372494 1.01947939344331 0.1468741614356327 0.47348315686494147 1109.7799558987501 1280154.8062205068 0.30255138546287696 0.11411772387874403 5.755568062824673e-09 8.239911805939487 0.519479702070816 QSSGPSS(ph)SPAAAAAPEKPGPK ddPTM_A459_Selumetinib_30min_R2 1 QSSGPSSSPAAAAAPEKPGPK 21 1 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 QS(0.034)S(0.023)GPS(0.152)S(0.396)S(0.396)PAAAAAPEKPGPK 91.691 0.0056957 0.0 23914.0 20690.0 23417.0 28928.0 28189.0 19909.0 27994.0 26775.0 17666.0 27109.0 True False 22584.955615326897 22276.85647116443 21910.37571450184 24987.956496416577 24647.645807142573 22651.28403409211 29295.776469058652 26852.910817160126 21199.693629281825 26326.292732359187 0.8578859106723525 0.84618281417887 0.8322621015138418 0.9491635130875232 0.9362368662279102 0.860405385003187 1.1127953626774612 1.0200035033475732 0.805266956681069 1.0 14.684216754970352 -6.025288579468938 1.0492109495455093 0.9711724449191922 0.838674184035095 0.2596698860378377 0.080881882722144 0.7654003703975679 1.7196620243888618 0.03430271456638571 0.06930189105298445 9.434337762338809e-07 6.025288579468938 -0.13249826088409722 QSSGPSSS(ph)PAAAAAPEKPGPK ddPTM_A459_Selumetinib_30min_R2 1 QSSGPSSSPAAAAAPEKPGPK 21 1 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 QS(0.047)S(0.033)GPS(0.07)S(0.21)S(0.64)PAAAAAPEKPGPK 82.51700000000002 0.00085268 10292000.0 24096.0 21311.0 24293.0 25607.0 24138.0 22323.0 26733.0 23995.0 21106.0 29031.0 True False 22756.840783930616 22945.4851743347 22730.01482821851 22119.28242546112 21105.568643542083 25397.790621981945 27976.137470434573 24064.821477413894 25327.789750912594 28192.799598403464 0.8071862712498874 0.8138774971334909 0.8062347532703241 0.7845720446547535 0.7486155665341329 0.9008608929856048 0.9923149835754105 0.8535804113180965 0.8983779586170253 1.0 14.783039126921707 -6.873812670371131 5.839662179386055 0.9266751288848838 0.7941156181786312 0.7154125139454035 0.043401740873186476 0.12355737416851881 5.870852092571809 0.015545655236612553 0.013720758001775272 1.337172171237832e-07 6.873812670371131 -0.1325595107062526 QSSGS(ph)ATNVASTPDNR ddPTM_A459_Selumetinib_30min_R2 1 QSSGSATNVASTPDNR 16 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 QSS(0.002)GS(0.994)AT(0.004)NVASTPDNR 190.8 1.0293e-06 5932400.0 5993.7 6017.1 7332.7 6938.6 9386.9 5405.2 4792.5 7337.5 4823.7 4902.4 True False 5660.594148682144 6478.59222197407 6860.922065240105 5993.55071024737 8207.633702049261 6149.717236479722 5015.360746158592 7358.850910211486 5788.574785439072 4760.854974035106 1.1889868898662241 1.360804363356416 1.4411113345519677 1.25892318563266 1.7239831389135565 1.291725387565728 1.0534579972529128 1.5456994490160711 1.2158687498377865 1.0 12.217004966606728 -8.530849577952845 22.415194472919037 0.9999999850753661 1.3589265418307612 0.2836939534146572 0.1765263401667647 313.0285682205721 880287.8344994743 0.1688164825045088 0.04358822836876646 2.9454416390245055e-09 8.530849577952845 0.3589265567553951 QSSGSAT(ph)NVASTPDNR ddPTM_A459_Selumetinib_30min_R2 1 QSSGSATNVASTPDNR 16 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 QSS(0.001)GS(0.087)AT(0.911)NVAS(0.001)TPDNR 248.01 6.6101e-29 4419100.0 7561.1 5047.5 8124.7 9989.7 11077.0 7465.8 7369.2 8152.4 7051.3 5749.8 True False 7140.884331481483 5434.627019729458 7601.9656475045085 8629.085626806305 9685.408230363562 8494.146182215329 7711.882401792781 8176.122134297522 8461.757029783474 5583.788334225494 1.2788601401152446 0.9732867176247064 1.361435139098794 1.545381936115817 1.7345586276967981 1.5212156467592033 1.3811201177743904 1.4642607571964137 1.5154150772366575 1.0 12.447028538718431 -5.469019767790703 5.277944371028631 1.4814076497081643 1.1293952345256184 0.3057223010501985 0.1897821181938155 0.21034019191854386 12.762740358981942 0.04844681464752408 0.10087884928389187 3.3960981421182956e-06 5.469019767790703 -0.3520124151825459 QSSLAEPVS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 QSSLAEPVSPSK 12 0 O43572;E7EMD6 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 QSSLAEPVS(0.993)PS(0.007)K;QSSLAEPVS(0.613)PS(0.387)K 157.37 0.00044409 36060000.0 11553.9 11732.5 11672.4 11657.400000000001 11629.5 10776.8 12869.7 14050.0 8578.3 12563.7 True False 11823.08339002416 10358.85344570872 10087.352191903725 9621.65392649971 10577.613778354984 10668.395176551505 11898.928167545082 13677.34835916809 14556.748565757049 14176.373275801372 0.833999159023683 0.7307125203447458 0.7115608481558906 0.6787105375479618 0.7461438530551845 0.7525475641052796 0.8393492422957134 0.9647988306370924 1.0268316361706533 1.0 13.791200876425897 -7.642383845143946 1.7547784461250275 1.016402901038124 0.7352386140615336 0.9021486398988782 0.037758152408844864 0.1075002752866231 0.6452773450381709 0.027384424391801544 0.012141244180483101 2.278327513742893e-08 7.642383845143946 -0.28116428697659035 QSSLAEPVS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 QSSLAEPVSPSK 12 0 O43572;E7EMD6 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 QSSLAEPVS(0.789)PS(0.211)K;QSSLAEPVS(0.5)PS(0.5)K;QSSLAEPVS(0.985)PS(0.015)K 182.7 0.00010423 165171000.0 550704.0 465089.0 485784.0 539236.0 513341.0 375108.0 524441.0 486571.0 398406.0 437067.0 True False 520098.0763227805 500759.8308031612 454529.18632162764 465791.12656601623 448850.5142532324 426775.7221086058 548828.5456601274 487986.84105383424 478098.3323937309 424447.7400735554 1.225352445586468 1.1797914879141098 1.0708719670479556 1.0974051280972688 1.0574930006116845 1.0054847318415383 1.2930415074539383 1.1496982902283042 1.1264009376298671 1.0 18.695227408007767 -8.806552269868165 0.010317024032418898 6.103722661538662e-07 2.1957975901128366 0.1380903529281795 0.08297673926486014 5395.203221553672 28.05058777859232 3044.3432227479548 2921.8484349902146 1.5611611318350759e-09 8.806552269868165 2.1957969797405705 QSSLAEPVSPS(ph)KK ddPTM_A459_Selumetinib_30min_R2 1 QSSLAEPVSPSKK 13 1 O43572;E7EMD6 O43572 AKAP10 A-kinase anchor protein 10, mitochondrial 1 QSSLAEPVS(0.063)PS(0.937)KK 78.848 0.020675 16542000.0 114860.0 92891.0 82969.0 116620.0 77322.0 75005.0 113050.0 92632.0 71102.0 96313.0 True False 108476.5410210107 100015.44100835818 77630.864869817 100736.15481927879 67608.11909254958 85336.25792240087 118307.04900432522 92901.5437839468 85324.38675586978 93532.19343877332 1.159777580668201 1.069315679780661 0.8299908514455462 1.0770211957578137 0.7228326056183663 0.9123731068946057 1.2648805149830005 0.9932574054810407 0.9122461862473437 1.0 16.513175400382842 -5.014244341857399 12.402097201399158 0.9669097171039867 1.1372664824644796 0.17491524902418643 0.1369269349061297 1.5736436097786481 1384.7438909987704 0.035888563549152645 0.10699638513986057 9.677332390093648e-06 5.014244341857399 0.17035676536049293 QSSPSPS(ph)RDR ddPTM_A459_Selumetinib_30min_R2 1 QSSPSPSRDR 10 1 Q15464 Q15464 SHB SH2 domain-containing adapter protein B 1 QSS(0.001)PS(0.362)PS(0.637)RDR 71.806 0.038503 2113500.0 6915.7 5097.3 5151.8 6397.2 5806.1 5014.6 6811.1 8676.8 6643.4 11036.0 True False 6531.353079740581 5488.246519597219 4820.338796855728 5525.890324214468 5076.685810807429 5705.315631993489 7127.829645938607 8702.048051478434 7972.265632105221 10717.36200502844 0.6094179777333414 0.512089310505907 0.4497691497771644 0.5156017237844346 0.4736880034868205 0.532343279000619 0.6650731441743152 0.8119580217030601 0.7438645469253294 1.0 13.387662220922406 -7.981025656550247 0.7934068528577651 0.9702113050990173 0.4985026378128911 0.8704698084686889 0.0600134255730715 0.2007515390616893 0.24940781840353501 0.05715789352312131 0.023933741862253322 1.0446585027445576e-08 7.981025656550247 -0.4717086672861262 QSSTAT(ph)SPTPSSDR ddPTM_A459_Selumetinib_30min_R1 1 QSSTATSPTPSSDR 14 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 QSS(0.001)T(0.006)AT(0.481)S(0.481)PT(0.015)PS(0.015)SDR 192.4 6.1159e-21 0.0 1020.0 1114.2 1330.9 1482.9 1186.8 1065.8 862.7 896.86 773.69 855.48 True False 1043.7640154254973 983.7489460224725 1150.171090110403 1223.939352480521 1079.454149546558 1055.079019668973 797.6258444362451 873.0723593881497 1312.895421918162 965.2891910808567 1.081296698512464 1.0191235487895043 1.1915300624287835 1.2679509558270798 1.1182702132382403 1.0930185786992772 0.8263076514335822 0.9044671456546098 1.3601057942522723 1.0 9.914817414057316 -7.012649622702715 23.683955331952507 1.0068882308513154 1.1362204349178648 0.11763470984436308 0.14330809894961472 615.6971570113566 1152772.9830908398 0.05450212374010244 0.044429945267196146 9.712932649384138e-08 7.012649622702715 0.12933220406654944 QSSTAT(ph)SPTPSSDR ddPTM_A459_Selumetinib_30min_R2 1 QSSTATSPTPSSDR 14 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 QSST(0.001)AT(0.499)S(0.499)PT(0.001)PS(0.001)SDR 113.52 0.007645199999999999 4911000.0 4417.7 5262.0 4689.1 5948.5 4580.1 4736.0 6151.0 5844.2 3795.3 3721.4 True False 4172.1819194542795 5665.578480003252 4387.4084111060565 5138.3040382651425 4004.706891386489 5388.341010872482 6437.033687975272 5861.20565444061 4554.466049542242 3613.953512641611 1.1544647447345366 1.5676954504768963 1.2140190502614103 1.4217958311559218 1.1081235210630194 1.490982380383163 1.781161175830991 1.6218265215471395 1.2602447800201961 1.0 11.81936223316876 -6.911974210127199 24.999319087549303 1.4917426312810798 1.3100429080753673 0.047510074337296704 0.2343410461176233 45.729154786539254 12976.638358662776 0.08004437109259473 0.07059249213245092 1.2246889232693528e-07 6.911974210127199 -0.18169972320571248 QSSTATS(ph)PTPSSDR ddPTM_A459_Selumetinib_30min_R2 1 QSSTATSPTPSSDR 14 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 QSSTAT(0.201)S(0.781)PT(0.017)PSSDR 233.62 1.1212e-13 7588200.0 13308.0 15665.0 13935.0 16652.0 15517.0 13802.0 16154.0 15127.0 13334.0 15055.0 True False 12568.394636144942 16866.455129086058 13038.437271280822 14383.968873697755 13567.615736259933 15703.1002179185 16905.193008543734 15171.017065590344 16001.172583088626 14620.323032412394 0.8596523215172163 1.1536308118291314 0.8918022701943983 0.9838338620705811 0.9279969879038465 1.074059730630141 1.156280403043484 1.0376663382852138 1.0944472668363736 1.0 13.835687567181173 -6.783512324963497 19.116780490491795 1.0800828993928544 0.9711123040490788 0.29927642015664047 0.08264883210383632 20.59408645008318 17834.246315962162 0.02768151908027463 0.02447538551519793 1.6462192471529928e-07 6.783512324963497 -0.10897059534377562 QSSTPGS(ph)LFLSPPAPAPK ddPTM_A459_Selumetinib_30min_R2 1 QSSTPGSLFLSPPAPAPK 18 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 QS(0.039)S(0.127)T(0.039)PGS(0.789)LFLS(0.006)PPAPAPK 107.73 0.001569 3726200.0 17320.0 28573.0 21279.0 28610.0 27137.0 16798.0 19193.0 17046.0 17829.0 19210.0 True False 16357.423737453457 30764.457223324378 19909.932306823455 24713.268644997177 23727.80745214192 19111.77202293835 20085.512530208 17095.60103788278 21395.298183882336 18655.357386425894 0.8768217836102957 1.6490950339932575 1.0672501145065396 1.3247276979522875 1.2719031300577959 1.0244656066918638 1.0766619000728832 0.9163909692945347 1.146871525465928 1.0 14.187302378122022 -6.7629627947403925 24.864321446622295 1.0303888965010801 1.2561370260441684 0.21917618957523444 0.19198725670583836 52.5183241272107 857162.6333219964 0.061099336204712903 0.05677549517773322 1.7259857478805194e-07 6.7629627947403925 0.22574812954308832 QSSTPGSLFLS(ph)PPAPAPK ddPTM_A459_Selumetinib_30min_R1 1 QSSTPGSLFLSPPAPAPK 18 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 QS(0.025)S(0.097)T(0.076)PGS(0.057)LFLS(0.745)PPAPAPK 98.227 0.0062519 0.0 1277.9 1466.8 1771.2 1919.3 1710.3 1431.8 1322.9 1566.3 963.68 1519.2 True False 1307.6725836394526 1295.0663741031797 1530.6807685051815 1584.1302847230854 1555.6036669779905 1417.3973919703853 1223.1125879271 1524.7566359405696 1635.2945755975834 1714.2041182611372 0.7628453167910575 0.7554913445295391 0.8929396168163923 0.9241199853900732 0.907478666283903 0.8268545016728649 0.7135163046789358 0.8894837083271389 0.9539672423937481 1.0 10.743323192753005 -14.52287873840456 0.11094027703375386 1.507919965852446 0.7583655089023633 0.36139403552589555 0.07129534732091124 224.23407802458536 1.6439660638925981 25.644802529598863 0.9877898100661762 3.0000000474961944e-15 14.52287873840456 -0.7495544569500827 QSSTPGSLFLS(ph)PPAPAPK ddPTM_A459_Selumetinib_30min_R2 2 QSSTPGSLFLSPPAPAPK 18 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 QS(0.001)S(0.002)T(0.006)PGS(0.03)LFLS(0.961)PPAPAPK;QSSTPGS(0.001)LFLS(0.999)PPAPAPK 113.86 0.0011355 11855700.0 62419.0 61710.0 65207.0 73738.0 76787.0 64300.0 73509.0 67467.0 67735.0 75783.0 True False 58950.00186305468 66442.95857107577 61011.65261201358 63694.75719485493 67140.33057551015 73156.74134271556 76927.31415532011 67663.31780023682 81283.89267402932 73594.94788211952 0.801006095655882 0.9028195614391978 0.8290195776718098 0.8654773055465411 0.9122953749903046 0.9940456980809897 1.045279823807175 0.9194016674706575 1.1044765301583683 1.0 16.167319111652645 -6.601542736342682 2.004503552399602 1.0129835942047036 0.8505131261348297 0.7130846323433324 0.04919558379405772 0.17715753502888643 1.4505130713649939 0.017614009147038638 0.0180576038526107 2.502979332921705e-07 6.601542736342682 -0.16247046806987397 QSSVTQVTEQS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 QSSVTQVTEQSPK 13 0 Q14966-3;Q14966;Q14966-2;Q14966-6;Q14966-4;C9JWN0 Q14966-3 ZNF638 Zinc finger protein 638 1 QSSVTQVT(0.006)EQS(0.994)PK;QSSVTQVTEQS(1)PK;QSSVTQVTEQS(1)PK;QSSVTQVT(0.001)EQS(0.999)PK 249.58 7.3933e-23 33823300.0 10800.199999999999 13362.900000000001 16120.3 15585.300000000001 11635.7 12925.300000000001 12058.1 12120.099999999999 9414.96 13527.0 True False 11051.823646469065 11798.365455756337 13931.251802469555 12863.61992731449 10583.252989449691 12795.283217233413 11148.547808967991 11798.635576366782 15976.499478528378 15263.322214137952 0.7240772022903439 0.7729880356471718 0.9127273608602365 0.8427798186294796 0.6933780759503816 0.8383026341002964 0.73041423436907 0.7730057330138824 1.0467249039484885 1.0 13.897781392849545 -8.260268235230694 24.997467407580327 1.0233624766955078 0.7884536438224294 0.697960844846929 0.06245151022286943 57.2268756274463 1221551.8993479093 0.04977293910470746 0.01641102791436989 5.49201563281494e-09 8.260268235230694 -0.2349088328730784 QSSVTQVTEQS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 QSSVTQVTEQSPK 13 0 Q14966-3;Q14966;Q14966-2;Q14966-6;Q14966-4;C9JWN0 Q14966-3 ZNF638 Zinc finger protein 638 1 QSSVTQVTEQS(1)PK;QSSVTQVT(0.004)EQS(0.996)PK;QSSVTQVTEQS(1)PK;QSSVTQVTEQS(1)PK 240.5 8.1175e-18 42116200.0 171467.0 157776.0 136205.0 148666.0 122783.0 116979.0 172142.0 138094.0 99045.6 133527.0 True False 161937.55057678564 169876.91187019966 127441.71858879122 128417.43433684538 107357.9018460529 133091.79542036584 180146.94409290198 138495.83067730753 118857.48756528927 129671.7285651899 1.248826959959701 1.3100535772128417 0.9828026509627533 0.9903271573362736 0.8279206503527161 1.0263748073155097 1.3892538187484458 1.068049544875786 0.916602939441314 1.0 16.984504447436315 -5.258761241405228 24.90433204174568 1.0323543081193354 1.2794402896525923 0.350391760866419 0.13821051893802125 269.33584463911865 2504548.5084100533 0.03911501584878684 0.09425742817012471 5.5111059278863874e-06 5.258761241405228 0.2470859815332569 QSTLYSFFPKS(ph)PALSDANK ddPTM_A459_Selumetinib_30min_R2 1 QSTLYSFFPKSPALSDANK 19 1 P52701-2;P52701;P52701-3;A0A087WWJ1;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 QSTLYSFFPKS(0.632)PALS(0.368)DANK 70.615 0.008629399999999999 3040200.0 17654.0 23848.0 18617.0 22212.0 21935.0 15597.0 10035.0 12866.0 8429.8 23929.0 True False 16672.861354561377 25677.064916593972 17419.202488656978 19186.687282162773 19179.329198611973 17745.34517453086 10501.64738397526 12903.437929919042 10115.995548291627 23238.10759499144 0.7174793079172641 1.1049550748326944 0.7495964298061593 0.8256561858031038 0.8253395471301517 0.7636312510385119 0.4519149135120926 0.5552705992591302 0.4353192490799874 1.0 14.504204966601522 -7.058866568906108 4.497424289424453 0.5741973860217303 0.8490980984430947 0.2722477007847195 0.17616401737637782 0.24164198148651636 9.945932778727796 0.06472728133166568 0.05083687052993646 8.732396182162637e-08 7.058866568906108 0.2749007124213644 QSVDKVTS(ph)PTKV ddPTM_A459_Selumetinib_30min_R1 2 QSVDKVTSPTKV 12 2 E7EX44;Q05682-3;Q05682-6;Q05682-2;Q05682;Q05682-5;Q05682-4 E7EX44;Q05682;Q05682-5 CALD1 Caldesmon 1 QSVDKVT(0.209)S(0.791)PTKV;QSVDKVT(0.065)S(0.708)PT(0.227)KV 175.88 0.0033798 166420000.0 8927.8 6967.8 14648.9 13747.5 10424.5 9050.3 9134.2 9871.0 6215.0 8001.8 True False 9135.800369525248 6152.006736757665 12659.659840647893 11346.757197535875 9481.605815594956 8959.26219901493 8445.199940013388 9609.18901447319 10546.401074359734 9028.908974132415 1.0118387942218794 0.6813676773553705 1.402125093620667 1.2567140980204843 1.0501385984463356 0.9922862468414487 0.935351099917904 1.064269120665992 1.1680703731286797 1.0 13.140335952024415 -5.241527218272887 24.998409546916655 1.103772278208342 0.8466032737330851 0.3255796117613029 0.1507136704650206 1028.2770487610314 1290929.8755403035 0.04029478345560043 0.10630052925176077 5.734199278227829e-06 5.241527218272887 -0.2571690044752568 QSVENDIHGLR ddPTM_A459_Selumetinib_30min_R1 2 QSVENDIHGLR 11 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 171.49 0.0004251 25862000.0 18318.4 18116.7 10344.8 16426.3 12174.6 8169.0 13564.099999999999 10824.0 7955.4 10407.099999999999 False True 18745.18307859845 15995.588341774659 8940.03297991892 13557.755064839692 11073.409579600208 8086.827276858551 12540.949016480437 10536.91235869291 13499.732760573032 11742.952658738463 1.5962921441780071 1.3621436453523994 0.761310484656194 1.154543960010837 0.9429834132355104 0.688653655674987 1.0679553414658578 0.897296673579955 1.1496029280614761 1.0 13.519507586168817 -5.070402334255811 4.256551612541014 0.9561344834686756 1.556625254575958 0.6865964638915791 0.14455686683003752 0.10803595032672056 3.6898179897975165 0.03631585535201686 0.1167627630311594 8.503499015076217e-06 5.070402334255811 0.6004907711072824 QSVENDIHGLR ddPTM_A459_Selumetinib_30min_R2 4 QSVENDIHGLR 11 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ;;; 193.62 2.858e-05 26687600.0 150307.0 145746.0 198882.0 205044.0 218996.0 139484.0 147114.0 171077.0 160289.0 166817.0 False True 141953.53866659428 156924.2495527465 186086.1486463492 177116.65347937113 191483.76463091976 158696.65489031604 153955.0925008609 171574.80574667812 192351.2788488593 162000.55976738216 0.8762533837563675 0.9686648600355161 1.1486759608334176 1.0933088980290826 1.1819944628948984 0.9796055959200992 0.9503367934155671 1.0591000796111056 1.1873494704281145 1.0 17.305639272560484 -5.013073202665263 4.300388535376151 1.073657601229756 0.8893364567337246 0.403151858873917 0.0779768304986126 0.19801459858676596 8.963985779657126 0.02114827097541517 0.07843901399357472 9.703463963687085e-06 5.013073202665263 -0.18432114449603143 QSWPS(ph)PAVK ddPTM_A459_Selumetinib_30min_R2 1 QSWPSPAVK 9 0 Q86XL3;F5H1D4;Q86XL3-3 Q86XL3 ANKLE2 Ankyrin repeat and LEM domain-containing protein 2 1 QS(0.001)WPS(0.999)PAVK 85.288 0.043336 0.0 23951.0 16105.0 24345.0 29386.0 26683.0 18538.0 27942.0 19899.0 18735.0 25666.0 True False 22619.899303449623 17340.201714263083 22778.669204831836 25383.5761063225 23330.84299095341 21091.44122879098 29241.358366022625 19956.902795543214 22482.523499637417 24924.95589172344 0.9075201337050618 0.69569638516476 0.9138900507501281 1.0184000411712404 0.9360435016336631 0.8461977353305804 1.1731759323085698 0.8006795631750782 0.902008557098508 1.0 14.605303331119835 -5.500731060520547 21.717447026993565 0.9506885695799719 0.802404267014251 0.2384194714274146 0.10721859135750549 191.90491028588426 188173.85444549876 0.027267882611449523 0.05574639721765788 3.156958984094608e-06 5.500731060520547 -0.1482843025657209 QSYVDTS(ph)PAAPVSYADMR ddPTM_A459_Selumetinib_30min_R2 2 QSYVDTSPAAPVSYADMR 18 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 QS(0.064)YVDT(0.214)S(0.722)PAAPVSYADMR;QSYVDT(0.07)S(0.93)PAAPVSYADMR 235.54 8.112399999999999e-20 7337000.0 33579.0 35132.0 36227.0 43750.0 40680.0 32937.0 35224.0 34479.0 33458.0 37047.0 True False 31712.813607387376 37826.511432815314 33896.194260975266 37791.17452704041 35569.41471618574 37473.772777683065 36861.985795031884 34579.32818169426 40150.534894628705 35977.35685033425 0.8814659103311184 1.051397733028959 0.9421535440189057 1.0504155345333357 0.9886611421776884 1.0415932702775779 1.0245884918221673 0.9611414291923728 1.1159945701863223 1.0 15.13480157950777 -4.752340191091295 24.993141614189415 1.016762205221656 0.8814656482008756 0.43072552269490616 0.04752665730424671 327.5481922964123 899625.8170268721 0.01085186091395688 0.12994803323076212 1.7687229413698523e-05 4.752340191091295 -0.13529655702078047 QT(ph)EPVSPVLK ddPTM_A459_Selumetinib_30min_R2 1 QTEPVSPVLK 10 0 Q8IYH5-4;Q8IYH5-2;Q8IYH5 Q8IYH5-4 ZZZ3 ZZ-type zinc finger-containing protein 3 1 QT(0.92)EPVS(0.08)PVLK 117.2 0.01426 7892900.0 80158.0 73231.0 71936.0 75535.0 77891.0 70200.0 83604.0 89628.0 80381.0 69316.0 True False 75703.139257898 78847.58222522178 67307.71607799482 65247.00269485707 68105.63622562503 79869.41278784799 87491.75165818326 89888.80264128593 96459.44603279205 67314.66697540318 1.1246158179102332 1.1713284157527324 0.9998967402243719 0.9692835993483911 1.011750325534714 1.1865083254000548 1.2997427691375611 1.335352408029165 1.4329632807667072 1.0 16.038633262799195 -6.991425340295749 3.4005053626774977 1.2928335022588267 1.0545942746726822 0.412717165202781 0.11772354673550298 0.21836039217155231 5.331435843825009 0.0457287472901995 0.037526124316753895 1.0199400832025349e-07 6.991425340295749 -0.23823922758614446 QT(ph)SPDPCPQLPLVPR ddPTM_A459_Selumetinib_30min_R2 1 QTSPDPCPQLPLVPR 15 0 Q5D1E8;A0A1W2PQC8 Q5D1E8 ZC3H12A Ribonuclease ZC3H12A 1 QT(0.987)S(0.013)PDPCPQLPLVPR 179.55 4.6762e-05 4775800.0 32402.0 35735.0 34257.0 37244.0 36713.0 25865.0 29480.0 32231.0 28013.0 32106.0 True False 30601.226555483077 38475.759593864685 32052.941916201456 32171.30295051642 32100.78472161571 29427.668970907278 30850.878413511793 32324.78687387073 33616.382748617194 31179.016358593977 0.9814686327347322 1.2340273712085688 1.0280292857079372 1.0318254617307365 1.0295637409602776 0.9438292931520282 0.9894756800115749 1.0367481290012197 1.0781732932813128 1.0 14.928287793891652 -5.490249611392474 24.9800334808346 1.0149353022070609 1.1135681123598815 0.2351685814214841 0.06546918155499441 777.161606752871 594973.8517024183 0.016349339146425133 0.03398575459805346 3.2340772443679313e-06 5.490249611392474 0.09863281015282066 QTAEESGITNSASSTLLS(ph)EYNVTNNSVALRTPR ddPTM_A459_Selumetinib_30min_R1 1 QTAEESGITNSASSTLLSEYNVTNNSVALRTPR 33 1 Q99459 Q99459 CDC5L Cell division cycle 5-like protein 1 QTAEESGITNSAS(0.006)S(0.012)T(0.01)LLS(0.282)EY(0.252)NVT(0.18)NNS(0.031)VALRT(0.227)PR 62.706 0.00020192 4637500.0 531.94 580.0 552.11 597.85 736.99 419.46 691.82 531.62 228.6 645.4 True False 544.33316702494 512.0933303653153 477.13649452314564 493.44672053441195 670.3293846261528 415.2406132392075 639.6354604125223 517.5197106548713 387.9175037165944 728.2433767283688 0.7474605117184246 0.7031898218778082 0.6551882375733782 0.6775849067810542 0.9204743991460732 0.5701948366556723 0.8783265057432896 0.7106411499131335 0.5326756358009223 1.0 9.50827686509045 -11.107220166400946 3.046063630764361 1.0154234276382812 0.7147884667857749 0.3677714245669902 0.11370104655578771 95973435.99113198 108996744.780498 12012611.753846323 0.026724110426818565 7.812316573312445e-12 11.107220166400946 -0.3006349608525063 QTAEESGITNSASSTLLSEYNVTNNSVALRT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 QTAEESGITNSASSTLLSEYNVTNNSVALRTPR 33 1 Q99459 Q99459 CDC5L Cell division cycle 5-like protein 1 QTAEESGITNSAS(0.004)S(0.009)T(0.02)LLS(0.02)EY(0.018)NVT(0.02)NNS(0.048)VALRT(0.861)PR 67.383 0.00020669 4188800.0 688.78 516.99 686.38 431.28 553.26 477.31 494.61 517.61 313.98 727.34 True False 704.8272338674249 456.4605704578693 593.1733660154616 355.9650441282611 503.2177306859868 472.50869476280513 457.3011694872043 503.8813013657649 532.8011278081204 820.7011738915575 0.8588110463219059 0.5561836451304788 0.7227641252208565 0.43373283169605437 0.6131558558639018 0.575737807857991 0.5572078900762354 0.6139643970246651 0.6492023464298365 1.0 9.680713206635291 -8.928326974563026 2.2430569595845617 0.9999817995543537 0.6087052032989682 0.5362615227715792 0.1061765235416599 2.537448212724244 13.206914319635105 0.09795317501462253 0.026684862247651167 1.1794323223205836e-09 8.928326974563026 -0.3912765962553856 QTAEETGLT(ph)PLETSR ddPTM_A459_Selumetinib_30min_R1 2 QTAEETGLTPLETSR 15 0 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 QTAEET(0.019)GLT(0.927)PLET(0.027)S(0.027)R;QTAEETGLT(1)PLETSR 177.66 4.5752e-05 15621400.0 4306.2 5095.5 5149.5 4915.1 5043.0 3929.3 5391.4 5396.799999999999 3162.6 4391.700000000001 True False 4406.526081593404 4498.916491166315 4450.226184178763 4056.7700528538703 4586.861540413965 3889.7748095189477 4984.722357358956 5253.659332723017 5366.701212835089 4955.417473780567 0.8892340766259589 0.907878400754401 0.8980527287004972 0.8186535391454912 0.9256256540812846 0.7849540084362209 1.005913706308993 1.0601850117614644 1.0829967891162855 1.0 12.274790888387086 -7.43969382244681 5.607671616749372 1.0502816602026026 0.8741851188806478 0.7769365073000358 0.04407973384209033 0.0979865103909971 5.056917599496284 0.018309209974230047 0.01207379402117337 3.633341150020451e-08 7.43969382244681 -0.17609654132195485 QTAEETGLT(ph)PLETSR ddPTM_A459_Selumetinib_30min_R2 2 QTAEETGLTPLETSR 15 0 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 QTAEET(0.002)GLT(0.998)PLETSR;QTAEET(0.436)GLT(0.538)PLET(0.023)S(0.003)R 170.0 0.00012982 12285000.0 34526.0 32801.0 35024.0 45837.0 45061.0 39294.0 43036.0 32300.0 32518.0 42986.0 True False 32607.183138528748 35316.731228161654 32770.59397124791 39593.92152676461 39400.03432954883 44706.39182458266 45037.259274216194 32393.987652447144 39022.508628834286 41744.88248895907 0.7811061187476785 0.8460134302091383 0.7850206304908216 0.9484736611065234 0.9438290870735971 1.070943051196919 1.078868991573468 0.7759990140351909 0.9347854467947104 1.0 15.349311727787063 -5.804727278566713 6.190498200405645 0.96456779260151 0.8081698229219481 0.4533010907082552 0.08086765273857709 0.18748078228518442 17.68036205195873 0.0246485661094631 0.03761565100069572 1.5677352428381927e-06 5.804727278566713 -0.156397969679562 QTAGQGS(ph)PCEEQEEPR ddPTM_A459_Selumetinib_30min_R2 2 QTAGQGSPCEEQEEPR 16 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 QTAGQGS(1)PCEEQEEPR;QTAGQGS(1)PCEEQEEPR 147.49 0.00031578 18179900.0 38077.2 29667.9 41589.6 46394.2 45799.8 37751.6 45020.9 60818.9 45583.4 35812.5 True False 35961.021659108665 31943.332532665994 38913.77041533271 40075.229925540996 40046.01966859305 42951.54022509579 47114.46105722094 60995.872929889105 54701.35370661184 34778.500072950446 1.0340015119593366 0.9184793037555535 1.1189030675189622 1.152298973258774 1.1514590791607917 1.235002663570936 1.3547007765830876 1.7538385152305533 1.5728497086381457 1.0 15.085908092988126 -7.02097962731011 1.4862556604975634 1.4946131414174924 1.0557697739208833 0.4139849009498101 0.1906781013878572 0.34285145768387904 1.5311873538273661 0.09662761968107436 0.07034211686276726 9.528408605990815e-08 7.02097962731011 -0.438843367496609 QTDFEHR ddPTM_A459_Selumetinib_30min_R1 2 QTDFEHR 7 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 ; 125.31 0.0085616 4290400.0 4614.0 4774.4 5713.5 4962.1 4933.7 5551.1 4379.1 4954.7 3687.7 4423.8 False True 4721.4972227188655 4215.411028441657 4937.6380820090035 4095.562385153138 4487.447706115483 5495.260973995534 4048.7809613663662 4823.285260866204 6257.757561048493 4991.637821461041 0.945881370322836 0.8444945685598271 0.9891819596325937 0.8204846849153764 0.8989930492998022 1.1008933681785198 0.8111127261595468 0.9662730817786855 1.2536481581544032 1.0 12.285297544956475 -8.068161659194217 7.64625937414764 1.1235975227411048 0.9166166942707934 0.4134060693157585 0.09908489123945094 0.2778257698598632 27.725880757024424 0.06350902035677539 0.02392543327781536 8.547484871693824e-09 8.068161659194217 -0.2069808284703114 QTDFEHR ddPTM_A459_Selumetinib_30min_R2 4 QTDFEHR 7 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 ;;; 195.81 3.214e-06 54138000.0 151661.0 128749.0 132372.0 141237.0 147612.0 117285.0 183904.0 238469.0 176963.0 203207.0 False True 143232.28876708593 138623.63430671574 123855.32963573637 122000.2769525854 129067.66089197669 133439.9441427744 192455.90039886296 239162.90530933213 212360.5447593458 197339.88591480753 0.7258152000195233 0.7024613076271877 0.6276244108563296 0.6182241181858869 0.6540373746222583 0.6761934797123628 0.9752508952090253 1.2119339392573671 1.0761156761336264 1.0 17.590323054400194 -7.362471156135891 3.184582905045212 1.1072764609871206 0.6619795517471889 0.9194355233048396 0.058438026441464244 0.06357741528246802 1.2300125377210671 0.0268802729830817 0.017167577229161336 4.3403908958960225e-08 7.362471156135891 -0.4452969092399317 QTDLELS(ph)PLTK ddPTM_A459_Selumetinib_30min_R1 2 QTDLELSPLTK 11 0 J3KTC5;Q8WVK7 J3KTC5 SKA2 Spindle and kinetochore-associated protein 2 1 QT(0.099)DLELS(0.572)PLT(0.329)K;QT(0.241)DLELS(0.735)PLT(0.024)K 118.08 0.0054127 4737100.0 4716.2 5495.4 4341.6 4767.299999999999 4332.4 4206.9 5231.8 5383.6 3072.1000000000004 4938.4 True False 4826.078283872282 4851.99601325785 3752.0345667017236 3934.7805483042553 3940.535184947346 4164.582405559584 4837.161113853656 5240.809439602661 5213.129322693568 5572.291744089515 0.8660849979707655 0.8707361775169655 0.6733377825526591 0.70613326240103 0.7071659859028451 0.7473733603372298 0.8680739157249607 0.9405123924391692 0.9355449359275009 1.0 12.444055078626496 -7.5202530825543485 2.3764918391983896 0.9572623993722548 0.7575291922458649 0.664170827325079 0.06306867655861316 0.20859674340747558 2.346793748569348 0.03934269182893732 0.021116128058652227 3.018192373977687e-08 7.5202530825543485 -0.19973320712638987 QTDPST(ph)PQQESSKPLGGIQPSSQTIQPK ddPTM_A459_Selumetinib_30min_R1 1 QTDPSTPQQESSKPLGGIQPSSQTIQPK 28 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 QT(0.002)DPS(0.052)T(0.842)PQQES(0.052)S(0.052)KPLGGIQPSSQTIQPK 110.36 2.55e-06 0.0 967.73 904.43 783.87 870.54 694.8 736.33 842.71 770.08 483.56 797.77 True False 990.2762261252116 798.5389151418998 677.4247594896995 718.5165310596747 631.955462676903 728.9231887341479 779.1437062302867 749.6549768276277 820.5660021749618 900.1715504378535 1.1000972266270026 0.8870963704123748 0.7525507323134045 0.798199555085006 0.7020389195476272 0.8097603044437379 0.8655502452297037 0.8327912345852156 0.911566247317891 1.0 9.81405615941842 -10.111690921571357 11.872445862325993 0.9999999989250187 0.8419688073792818 0.1550954111029672 0.1023132416810943 0.0 0.0 0.10331074302209783 0.02505653563183248 7.732306816602374e-11 10.111690921571357 -0.15803119154573686 QTDPST(ph)PQQESSKPLGGIQPSSQTIQPK ddPTM_A459_Selumetinib_30min_R2 1 QTDPSTPQQESSKPLGGIQPSSQTIQPK 28 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 QTDPS(0.028)T(0.417)PQQES(0.278)S(0.278)KPLGGIQPSSQTIQPK 96.723 1.6447e-06 14650000.0 121260.0 104170.0 108460.0 126300.0 117080.0 98581.0 106710.0 105030.0 94199.0 107940.0 True False 114520.85464224058 112159.50404065738 101481.80168231926 109097.72212034749 102371.36369151976 112159.63792078124 111672.22644185346 105335.6199113476 113041.4321399705 104823.49173819959 1.0925113516372884 1.0699844298335315 0.9681207904786617 1.0407755009041575 0.9766070753223512 1.069985707029336 1.065335876434634 1.0048856240586517 1.0783978883502134 1.0 16.677602546429135 QTDPSTPQQES(ph)SKPLGGIQPSSQTIQPK ddPTM_A459_Selumetinib_30min_R2 3 QTDPSTPQQESSKPLGGIQPSSQTIQPK 28 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 QTDPS(0.012)T(0.048)PQQES(0.752)S(0.188)KPLGGIQPSSQTIQPK;QTDPS(0.003)T(0.009)PQQES(0.81)S(0.178)KPLGGIQPSSQTIQPK;QTDPS(0.058)T(0.151)PQQES(0.395)S(0.395)KPLGGIQPSSQTIQPK 143.25 2.6525999999999997e-13 34005200.0 138135.0 117552.0 132328.0 158398.0 141736.0 123437.0 135893.0 141541.0 121432.0 126124.0 True False 130458.00969821787 126567.86041074553 123814.16054783275 136823.9191482091 123929.8565440832 140439.32630047863 142212.29376687104 141952.8608766262 145721.7930935664 122482.47241049365 1.0651157437530705 1.0333548786193663 1.0108724792301385 1.117089788077194 1.011817071496881 1.1466075393204305 1.1610828142842669 1.1589646917060799 1.1897358881292612 1.0 16.90221578467942 -6.774260840690602 24.985961843177947 1.1430762947162305 1.048670392310127 0.3496955646270816 0.05586606508432844 221.560819254544 431766.13290437224 0.018507164417509075 0.01642553792429451 1.681663737194726e-07 6.774260840690602 -0.09440590240610347 QTEPVS(ph)PVLK ddPTM_A459_Selumetinib_30min_R2 1 QTEPVSPVLK 10 0 Q8IYH5-4;Q8IYH5-2;Q8IYH5 Q8IYH5-4 ZZZ3 ZZ-type zinc finger-containing protein 3 1 QT(0.282)EPVS(0.718)PVLK 104.09 0.013524 8254300.0 46514.0 35325.0 54643.0 50658.0 56428.0 47698.0 57631.0 56106.0 54826.0 46981.0 True False 43928.93809029503 38034.313912222475 51127.328870800025 43758.29301007575 49339.01016727949 54267.96654066632 60310.95569366001 56269.25917115168 65792.73196643301 45624.53645870251 0.9628358225635395 0.8336372676717406 1.1206103741366977 0.9590956184219864 1.0814139495299677 1.1894469676374135 1.3218973906343368 1.2333113613567197 1.442047132379875 1.0 15.477522280848572 -6.638571962441395 1.5012435316429866 1.2717051698370332 0.9603195107734986 0.5179378359516251 0.1223069821426653 0.2895104289273195 1.3519068581845541 0.049774609593776845 0.04997980637379916 2.2984128315194198e-07 6.638571962441395 -0.31138565906353455 QTETEMLYGSAPRT(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 QTETEMLYGSAPRTPSK 17 1 O43663-3;O43663-2;O43663-4;O43663;G3V3N7;H0YL53 O43663-3 PRC1 Protein regulator of cytokinesis 1 1 QTETEMLYGS(0.006)APRT(0.993)PS(0.001)K 158.58 0.0011303 0.0 439.43 205.78 960.87 1134.9 496.78 476.95 522.5 270.02 238.6 359.12 True False 449.6678640180647 181.68718193547335 830.3891316811049 936.7110197114724 451.8463367136325 472.15231603595146 483.0874043328367 262.8581924514285 404.8867733454918 405.21655012502595 1.1096976761667896 0.44837058575079275 2.0492478192830372 2.3116307056620924 1.1150737465540816 1.1651851729409204 1.1921709618814542 0.6486857271015362 0.9991861714941495 1.0 8.66254928863169 -7.108847904028691 1.636802203037548 0.8994771014581621 1.435223011295765 0.1628642901290288 0.49463682016674615 0.7667548296696273 4.078011464042727 0.28080494812494655 0.19348842194556207 7.783090779859011e-08 7.108847904028691 0.5357459098376028 QTETSVNASRS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 QTETSVNASRSPEK 14 1 H0YG46;J3KNE4;A0A0A0MTP3;Q99550-2;Q99550;U3KQJ0 H0YG46 MPHOSPH9 M-phase phosphoprotein 9 1 QTETSVNASRS(1)PEK 172.26 0.00059731 2962600.0 832.31 768.58 1137.8 1476.4 1335.7 1199.6 887.59 789.6 669.72 1096.7 True False 851.7012036066616 678.5942962968514 983.2930094880279 1218.5744554604082 1214.886170836988 1187.5331131496537 820.6383716971909 768.6572430177318 1136.4659255865165 1237.4721277626302 0.6882588985228711 0.5483713782901608 0.7945981064364155 0.9847288097418491 0.9817483105930814 0.9596443317852604 0.6631570548428581 0.6211511562749108 0.9183769881276158 1.0 10.273180315639 -5.417667097145475 5.0545087234165615 0.8609203981980572 0.6218519162014664 0.37477220492323804 0.13008152329019057 0.26207377447920366 10.085495823511922 0.038041264938190926 0.08126623725454644 3.822371575529008e-06 5.417667097145475 -0.2390684819965908 QTGIET(ph)PNK ddPTM_A459_Selumetinib_30min_R1 2 QTGIETPNK 9 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 QTGIET(1)PNK;QTGIET(1)PNK 129.74 0.0093792 44465000.0 14087.0 15631.4 12438.599999999999 12058.7 11831.1 12499.5 12965.3 11812.9 8084.5 12503.4 True False 14415.199691469588 13801.268421159288 10749.506440339062 9952.874414833675 10760.979093950355 12373.76637863796 11987.316982577082 11499.58351829301 13718.8060314821 14108.33318342963 1.0217507273219473 0.9782352203993174 0.7619260404882172 0.7054606866333026 0.7627392232690695 0.8770537396416939 0.8496621696357652 0.8150915752258657 0.9723902783636388 1.0 13.784259931620303 -8.335023262182286 4.9944812868046125 0.9950512065502167 0.8417410756825238 0.26955128636182013 0.0919177712693795 0.3289014916575094 14.666461345905667 0.09700159271876391 0.025644758460013347 4.623562554766056e-09 8.335023262182286 -0.15331013086769296 QTGIET(ph)PNK ddPTM_A459_Selumetinib_30min_R2 3 QTGIETPNK 9 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 QTGIET(1)PNK;QTGIET(1)PNK;QTGIET(1)PNK 166.24 0.0021566 68276000.0 255791.0 250759.0 226976.0 243317.0 237758.0 218803.0 280329.0 236209.0 218225.0 233113.0 True False 241575.16023250314 269991.4089827324 212372.61127278354 210176.80485476338 207888.71445651146 248941.12715412426 293364.8539613751 236896.3290834947 261876.09771595243 226382.4219896883 1.0671109448749818 1.1926341568826861 0.9381144057309233 0.9284148610457791 0.9183076699567282 1.0996486607315452 1.2958817711329982 1.0464431248742683 1.1567863591806649 1.0 17.788402415412094 -6.984933050801386 23.909586846298303 1.1385219488351128 1.0105432368003477 0.21738136507220396 0.10469859441694986 212.797587308472 337683.9463399911 0.03865829929390815 0.03407830362729364 1.035301752590139e-07 6.984933050801386 -0.12797871203476507 QTGYGWICQECDSSS(ph)SKEDENEAERK ddPTM_A459_Selumetinib_30min_R2 1 QTGYGWICQECDSSSSKEDENEAERK 26 2 A0A0U1RRH6;O94880-2 A0A0U1RRH6 PHF14 PHD finger protein 14 1 QTGYGWICQECDS(0.135)S(0.135)S(0.365)S(0.365)KEDENEAERK 51.39 0.010399 9841700.0 20813.0 17724.0 18286.0 18604.0 19723.0 11277.0 14645.0 11588.0 10949.0 15404.0 True False 19656.29678104034 19083.373808357577 17109.49866829144 16070.103106309949 17245.22041414286 12830.304387586355 15326.021518516976 11621.71916150333 13139.105940620777 14959.246495601483 1.313989764579382 1.275690845389086 1.143740673925134 1.0742588613026127 1.1528134401163541 0.8576838673899044 1.024518281921709 0.7768920155784921 0.8783267221704055 1.0 13.868749887366118 -5.926651742085345 0.6168385514557143 0.8789384365796423 1.360035097317333 0.7458460202595264 0.08507336522083529 0.5592812603975358 0.3846654184039044 0.052542263710781766 0.1610136961992074 1.1839906095077504e-06 5.926651742085345 0.48109666073769064 QTISPGS(ph)TASK ddPTM_A459_Selumetinib_30min_R1 1 QTISPGSTASK 11 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4 Q8IVL0-3 NAV3 Neuron navigator 3 1 QTIS(0.167)PGS(0.416)T(0.416)ASK 126.5 0.0031469 5636500.0 2096.0 2030.0 2455.3 2265.2 2658.4 2124.9 2147.8 2282.0 1283.3 1657.9 True False 2144.8327218939617 1792.326656278603 2121.883745997499 1869.6253430702504 2417.948189378639 2103.525435254834 1985.7897167963004 2221.4739470193294 2177.666371476403 1870.7076143135457 1.1465355170861407 0.9581009039385855 1.1342679795399893 0.9994214642443242 1.2925313239107667 1.1244544145540993 1.0615179526732101 1.1875046266032852 1.1640869769354607 1.0 10.869368372186274 QTLENS(ph)QTSSR ddPTM_A459_Selumetinib_30min_R2 1 QTLENSQTSSR 11 0 B4DZ85;B4DF87;Q13772;Q13772-3;Q13772-4 B4DZ85 NCOA4 Nuclear receptor coactivator 4 1 QT(0.001)LENS(0.612)QT(0.384)S(0.004)SR 109.95 0.0090995 4495700.0 11883.0 7620.2 11077.0 11832.0 12951.0 10463.0 10180.0 11678.0 10289.0 10538.0 True False 11222.590431417968 8204.644837195128 10364.317879725706 10220.461188661537 11323.979596590998 11904.183276342648 10653.390171287312 11711.981046603025 12347.087498679979 10233.740558987833 1.0966264355374606 0.8017249206097333 1.0127594910175042 0.9987023932989357 1.1065337772947212 1.1632289491536643 1.0410064736232658 1.1444477196871012 1.206507769814048 1.0 13.321045943942611 -6.0949866236540515 2.027956423612946 1.118452896344207 0.9516758350317971 0.35189009203558674 0.08794399630167905 0.3224429399915321 2.6245142253500515 0.027687482512928376 0.04072372355134358 8.035508713117574e-07 6.0949866236540515 -0.16677706131241 QTLPS(ph)SPTTTK ddPTM_A459_Selumetinib_30min_R1 2 QTLPSSPTTTK 11 0 F8VW64;F8VWX1;F8W659;J3KQU3;P51513-2;P51513 F8VW64 NOVA1 RNA-binding protein Nova-1 1 QT(0.02)LPS(0.67)S(0.304)PT(0.004)T(0.001)TK;QTLPS(0.577)S(0.301)PT(0.091)T(0.027)T(0.004)K 134.04 0.0017047999999999998 19328300.0 8901.099999999999 8668.8 9267.099999999999 9251.900000000001 9197.6 8109.8 8820.099999999999 8971.599999999999 5374.3 7605.4 True False 9108.478311474395 7653.852865984216 8008.678720536566 7636.229344672281 8365.678703968166 8028.22277510925 8154.792755896754 8733.644024136118 9119.794576658325 8581.627172869437 1.061392918614617 0.8918882994802719 0.9332354528119993 0.8898346654832543 0.9748359530714658 0.9355128827421262 0.9502618316579742 1.0177142222802777 1.0627115805601866 1.0 13.067035509503203 -7.790750605124694 3.8569591904572804 1.0338254585373345 0.9430757457350486 0.3642053888166277 0.0475597408929387 0.21608598606835874 6.833830150332629 0.026343710511931726 0.012474377134508654 1.6190094916782572e-08 7.790750605124694 -0.09074971280228594 QTLPS(ph)SPTTTK ddPTM_A459_Selumetinib_30min_R2 2 QTLPSSPTTTK 11 0 F8VW64;F8VWX1;F8W659;J3KQU3;P51513-2;P51513 F8VW64 NOVA1 RNA-binding protein Nova-1 1 QTLPS(0.296)S(0.296)PT(0.203)T(0.203)T(0.003)K;QTLPS(0.739)S(0.259)PT(0.002)T(0.001)TK 192.65 2.0179e-05 28490600.0 170303.0 141810.0 167776.0 171631.0 181937.0 135929.0 154414.0 152669.0 128044.0 139448.0 True False 160838.2410369247 152686.37100898163 156981.47482069698 148254.56172001065 159080.44752258316 154651.9859093931 161594.55696553632 153113.24151428658 153656.37784828246 135421.77391058407 1.1876837556648945 1.1274876011430552 1.1592040946410014 1.0947616283471502 1.1747036161822866 1.1420023637521266 1.1932686472725837 1.1306397567601187 1.1346504584243466 1.0 17.047100197007715 -9.044436414949669 1.5283947390609676 1.0000219102715553 1.1508175710829236 0.7202203254064363 0.02813783910293738 1.5997819527321688 4.165133907366889 0.025993115160214453 0.007474090797204661 9.027418682229359e-10 9.044436414949669 0.1507956608113683 QTLPSS(ph)PTTTK ddPTM_A459_Selumetinib_30min_R1 2 QTLPSSPTTTK 11 0 F8VW64;F8VWX1;F8W659;J3KQU3;P51513-2;P51513 F8VW64 NOVA1 RNA-binding protein Nova-1 1 QTLPS(0.227)S(0.724)PT(0.023)T(0.023)T(0.004)K;QT(0.002)LPS(0.382)S(0.601)PT(0.012)T(0.003)TK 139.77 0.0011411 22190700.0 7918.9 8166.200000000001 8898.6 9163.5 9300.9 8058.0 8363.5 9114.3 4964.0 7430.5 True False 8103.394962502913 7210.097507636621 7690.218996510951 7563.266745198766 8459.635237207267 7976.943836078616 7732.634461507524 8872.5591565812 8423.545443784666 8384.277054199165 0.9664989491782627 0.8599545865466754 0.9172190931667027 0.9020773879855025 1.0089880358820393 0.9514170135973095 0.922278022484327 1.058237830074745 1.0046835749023624 1.0 13.03347067545385 -6.8735211411757104 0.6595503359386413 1.01687601770618 0.9043395303260447 0.42153220751316345 0.0432742790811133 0.7145167448161157 0.6704405470330055 0.034773646431388944 0.03296120495203502 1.3380700771789025e-07 6.8735211411757104 -0.11253648738013522 QTLPSS(ph)PTTTK ddPTM_A459_Selumetinib_30min_R2 1 QTLPSSPTTTK 11 0 F8VW64;F8VWX1;F8W659;J3KQU3;P51513-2;P51513 F8VW64 NOVA1 RNA-binding protein Nova-1 1 QTLPS(0.062)S(0.932)PT(0.005)T(0.001)TK 217.68 1.7272e-05 23783000.0 168130.0 140230.0 163490.0 196830.0 166700.0 124100.0 146960.0 155390.0 120710.0 128220.0 True False 158786.00767771644 150985.19008948238 152971.23139445277 170021.4144493114 145757.65568309155 141193.64853236394 153793.9311957155 155842.1591738005 144855.37291920139 124517.95544443131 1.2752057091764404 1.2125575749343445 1.2285074136373795 1.3654369270878925 1.170575401457976 1.13392199565447 1.235114491293982 1.251563749320862 1.163329195393399 1.0 16.92599426783746 -14.522878745272232 0.19144039611336414 0.004689662269474344 1.2673998554206733 0.6036641608117492 0.057813730438552965 100.85089919211408 0.9854316111980359 38.17341614082114 0.16246018775066426 3.000000000055992e-15 14.522878745272232 1.262710193151199 QTNGCLNGYT(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 QTNGCLNGYTPSR 13 0 A0A2R8Y653;Q9BZX2-2;Q9BZX2 A0A2R8Y653 UCK2 Uridine-cytidine kinase 2 1 QTNGCLNGYT(0.997)PS(0.003)R;QTNGCLNGYT(0.952)PS(0.048)R 174.24 0.00030098 12335700.0 2295.3999999999996 2698.0 2716.6 2732.8 2448.8 1957.45 2576.4 2437.3 1496.24 1930.46 True False 2348.8783539291026 2382.1169057338298 2347.700641215659 2255.567781009351 2227.3064723707535 1937.7598302223973 2382.0600737284603 2372.6548865338377 2539.009998954142 2178.2533452727703 1.0783311128738176 1.0935903809827643 1.0777904444910515 1.0354937757375047 1.0225194774540058 0.8895934141121417 1.0935642903512532 1.0892465248282328 1.165617399125902 1.0 11.088956043451894 -10.053994301340454 8.970698245286673 1.000011959562222 1.057030551994914 0.0647930114370524 0.06787859509631795 0.0 0.0 0.07027321993111678 0.017043759319309102 8.830914879586548e-11 10.053994301340454 0.057018592432691806 QTNGCLNGYT(ph)PSR ddPTM_A459_Selumetinib_30min_R2 3 QTNGCLNGYTPSR 13 0 A0A2R8Y653;Q9BZX2-2;Q9BZX2 A0A2R8Y653 UCK2 Uridine-cytidine kinase 2 1 QTNGCLNGYT(0.903)PS(0.097)R;QTNGCLNGYT(0.976)PS(0.024)R;QTNGCLNGYT(0.998)PS(0.002)R 158.91 0.00085232 19341800.0 24945.2 25041.1 28839.600000000002 31693.1 30423.9 27225.699999999997 25876.699999999997 25698.5 26763.1 29615.7 True False 23558.84564754755 26961.67185017281 26984.0915341823 27376.445106353032 26601.7776888831 30975.79304470249 27080.017823708287 25773.278380384298 32116.46782349326 28760.617790170414 0.8191355908773043 0.9374510675284439 0.9382305947337722 0.9518726373016071 0.9249376311372162 1.0770211290554808 0.9415659295386725 0.8961309026259128 1.1166821261561977 1.0 14.811807045355955 -2.9986162458797345 0.489294538699498 0.9944894378581309 1.5367667966031407e-12 0.3968129579106505 0.06327775130436543 26.54975567787666 1.2042994904741524 0.036036017655404574 22.10644546795831 0.0010031912929772408 2.9986162458797345 -0.9944894378565942 QTNPSAMEVEEDDPVPEIR ddPTM_A459_Selumetinib_30min_R1 2 QTNPSAMEVEEDDPVPEIR 19 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ; 182.57 4.1768e-11 6722300.0 631.37 789.5799999999999 508.81 602.22 906.44 560.27 786.79 412.98 312.01 454.70000000000005 False True 646.079692567839 697.1356065342162 439.7163966932706 497.0535820694714 824.4526620449802 554.6341924844579 727.441796851737 402.0264288519031 529.4581816912274 513.0651741530664 1.2592546232247082 1.3587661795307018 0.8570380895938317 0.968792284313536 1.6069160480555542 1.0810209315025343 1.4178350694968707 0.7835776994911833 1.0319511211518526 1.0 9.002998291348046 -7.768730120801472 24.99992333093284 0.9308233293032289 1.21236166611675 0.2662298499242933 0.21472091755321135 245.19653223519765 840761.4770266182 0.1162946626455366 0.05766458139845878 1.7032165921509556e-08 7.768730120801472 0.28153833681352114 QTPMAS(ph)SPRPK ddPTM_A459_Selumetinib_30min_R1 1 QTPMASSPRPK 11 1 Q5SSJ5;B0QZK4;Q5SWC8;Q5SSJ5-2 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 QT(0.001)PMAS(0.5)S(0.5)PRPK 112.08 0.037386 5985600.0 2572.5 4384.0 3622.0 3967.9 3472.0 3278.4 3487.9 2876.2 1704.3 2610.9 True False 2632.4342447863633 3870.719241933695 3130.1522942218644 3274.9807517077707 3157.9582130313856 3245.422272549035 3224.804894875599 2799.9138327857145 2892.0726228529825 2946.0344473196433 0.8935517529950815 1.3138744000279245 1.062496841158709 1.1116573177504454 1.0719352639968465 1.101624006977169 1.0946256578260944 0.9504009144676254 0.9816832337056492 1.0 11.524558584243817 -7.7525997560771955 23.810804410471917 0.9745315560295567 1.1004186368429818 0.23046939344782225 0.09594270890520985 131.89280398921272 355276.8095704847 0.04304902807739071 0.024332997764014448 1.7676661437429643e-08 7.7525997560771955 0.12588708081342515 QTPMASS(ph)PRPK ddPTM_A459_Selumetinib_30min_R1 1 QTPMASSPRPK 11 1 Q5SSJ5;B0QZK4;Q5SWC8;Q5SSJ5-2 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 QT(0.001)PMAS(0.249)S(0.75)PRPK 76.311 0.028387 9458500.0 2649.8 3781.4 3352.9 3767.0 3410.9 3104.1 3377.0 2506.7 1730.8 2326.2 True False 2711.5351843867456 3338.671930074833 2897.5945961613716 3109.164165347709 3102.3846972433057 3072.8755722972987 3122.2701711617024 2440.214173090867 2937.0411873695616 2624.7904291068016 1.0330482595174133 1.271976571177517 1.1039336946787799 1.184538060970352 1.1819552002477494 1.1707127312800274 1.1895312237267603 0.929679621668407 1.1189621673411148 1.0 11.357986523075843 -7.744994799870727 24.98976632371939 1.018240655717384 1.1661616933154157 0.4607846090379174 0.07229308600558863 184.45351213389722 280302.92068368505 0.031153437434116856 0.017921585612691544 1.7988924544706337e-08 7.744994799870727 0.14792103759803177 QTPMASS(ph)PRPK ddPTM_A459_Selumetinib_30min_R2 2 QTPMASSPRPK 11 1 Q5SSJ5;B0QZK4;Q5SWC8;Q5SSJ5-2 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 QTPMAS(0.22)S(0.78)PRPK;QT(0.001)PMAS(0.395)S(0.604)PRPK 65.565 0.044074 40636000.0 54025.0 43821.0 54977.0 53431.0 53958.0 35494.0 46854.0 53611.0 39986.0 53036.0 True False 51022.50677921029 47181.929793276766 51439.83967443173 46153.60562638393 47179.31364935966 40382.97631754812 49032.80383943967 53766.99913422116 47984.31730218854 51504.712875923164 0.9906376315916074 0.9160701450164347 0.9987404414495482 0.8961045125631463 0.9160193507537154 0.7840637111177042 0.9520061583016992 1.0439238689427883 0.9316490593353002 1.0 15.652416829935305 -7.524498159814732 24.992176770194757 0.9922648979078186 0.9153296550415486 0.23576549008979508 0.06052502766873092 80.4797691777959 1241961.2413320518 0.02894070658755544 0.016867022636207436 2.9888343111709785e-08 7.524498159814732 -0.07693524286626996 QTPS(ph)PDVVLR ddPTM_A459_Selumetinib_30min_R1 2 QTPSPDVVLR 10 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 QT(0.004)PS(0.996)PDVVLR;QT(0.09)PS(0.91)PDVVLR 140.01 0.0014653 58081000.0 6475.6 6465.2 6227.3 6311.5 6801.3 5701.200000000001 6727.8 6609.9 3400.6 4950.200000000001 True False 6626.468880675833 5708.251378410066 5381.666864110383 5209.315006528291 6186.123615867039 5643.851104275431 6220.316629417143 6434.583980018873 5770.569830002845 5585.606389031249 1.1863472681656517 1.0219573276089882 0.9634883823318893 0.932631955011742 1.1075115547015733 1.010427644052857 1.1136331843275438 1.151993809061592 1.0331142991627227 1.0 12.447498196876367 -7.258148143002257 24.736899165887504 1.0873514731996687 1.0314855283828095 0.040975210999284806 0.07754565733128034 637.1429753758056 4788788.981269561 0.031187544035103165 0.023091732364056285 5.518891512292865e-08 7.258148143002257 -0.05586594481685925 QTPS(ph)PDVVLR ddPTM_A459_Selumetinib_30min_R2 4 QTPSPDVVLR 10 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 QT(0.025)PS(0.975)PDVVLR;QT(0.045)PS(0.955)PDVVLR;QT(0.151)PS(0.849)PDVVLR;QT(0.081)PS(0.919)PDVVLR 152.0 0.0006502999999999999 106729900.0 139168.0 110875.0 124019.0 128829.0 144148.0 94067.0 107790.0 125773.0 93531.0 119721.0 True False 131433.5996936445 119378.75598068416 116039.75256167752 111282.26795757943 126038.83954052965 107023.87539479356 112802.4485818331 126138.97860715885 112239.81347449076 116264.34365748557 1.1304721254940167 1.0267873384498143 0.9980682719332274 0.9571487221001882 1.0840713117672578 0.9205219074739337 0.970223931372707 1.0849326168198559 0.9653846565818057 1.0 16.827049188480956 -4.751089022343303 2.6432914032637926 0.9987325173695885 1.1633275817528497 0.3931328710382235 0.049496670372021045 0.5560289443704048 4.77007409506505 0.012531845497645962 0.21246155119893925 1.7738258421033723e-05 4.751089022343303 0.1645950643832612 QTQS(ph)ASSTLQK ddPTM_A459_Selumetinib_30min_R2 2 QTQSASSTLQK 11 0 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819 G5E948 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 QT(0.032)QS(0.964)AS(0.001)S(0.002)TLQK;QT(0.1)QS(0.823)AS(0.016)S(0.055)T(0.006)LQK 122.66 0.0040868 20576000.0 48914.0 33144.0 41097.0 41056.0 41893.0 33721.0 42086.0 35624.0 28285.0 33562.0 True False 46195.55569825624 35686.03822524283 38452.86376303034 35464.10197444961 36630.02681182818 38365.76166123967 44043.08239182692 35727.65994212934 33942.7903489322 32592.977855451652 1.4173468869009573 1.0948995941245 1.1797898287651718 1.0880902669198027 1.1238625379454634 1.1771174095042816 1.3513058729139742 1.09617660897939 1.0414142119651326 1.0 14.992273549392985 -14.522878745279021 0.06827995714291672 0.39820743697977745 1.3920863134764387 0.27947427759443977 0.10665370720292408 523.0587179649333 2.568468098139433 49.85944881982828 6.4955662942455135 3.000000000009094e-15 14.522878745279021 0.9938788764966613 QTQSAS(ph)STLQK ddPTM_A459_Selumetinib_30min_R2 2 QTQSASSTLQK 11 0 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819 G5E948 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 QTQS(0.128)AS(0.659)S(0.195)T(0.017)LQK;QT(0.017)QS(0.09)AS(0.874)S(0.018)T(0.002)LQK 227.48 4.7319e-07 31483000.0 68910.0 45153.0 60036.0 65821.0 64185.0 47641.0 53361.0 50024.0 44766.0 50637.0 True False 65080.258068586445 48616.0899102217 56173.34912225446 56856.066252441786 56121.50647881961 54203.115308060835 55842.39223281553 50169.561558081004 53720.45086654758 49174.97823927376 1.3234425392507827 0.9886347010397718 1.1423156884570094 1.1561991136181835 1.14126144003045 1.1022499093811766 1.1355854996234003 1.020225394182542 1.0924346647426386 1.0 15.585636793637418 -6.75998763350895 0.018884741413990883 8.461346751375225e-07 2.223298034140882 0.30290626849609315 0.07725858544465351 922.1481871442697 6.827068350993629 380.6705137070692 421.823311892488 1.7378503131551503e-07 6.75998763350895 2.2232971880062067 QTQSES(ph)SNYDSELEK ddPTM_A459_Selumetinib_30min_R1 1 QTQSESSNYDSELEK 15 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 QTQSES(0.389)S(0.389)NYDS(0.222)ELEK 194.67 3.2678e-05 7428000.0 1440.1 1996.9 1207.2 1536.4 1573.8 1771.6 1949.6 2160.9 1270.9 2344.7 True False 1473.6515280531946 1763.1020196663753 1043.2688706749404 1268.0965817998992 1431.4500678769566 1753.7793124841 1802.5401023680345 2103.5859124075696 2156.6244771365696 2645.6650843120633 0.5570060763894382 0.6664116445127537 0.3943314204285292 0.4793110773239217 0.5410549038746407 0.6628878775637337 0.6813183244759562 0.795106653854697 0.8151540003776948 1.0 11.369414726556888 -7.885092121068899 0.6979609346669797 0.9828554159677465 0.519251530774439 0.8251969782929311 0.07075673151724352 0.284876185834109 0.27956195922710997 0.07171090594097408 0.033909521488454455 1.3028903844609372e-08 7.885092121068899 -0.46360388519330753 QTQSESS(ph)NYDSELEK ddPTM_A459_Selumetinib_30min_R2 1 QTQSESSNYDSELEK 15 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 QTQSES(0.054)S(0.637)NYDS(0.309)ELEK 231.41 5.6716999999999995e-14 12015000.0 88862.0 61329.0 74064.0 60215.0 61991.0 58754.0 77961.0 82628.0 56303.0 62923.0 True False 83923.40578277064 66032.73709618386 69298.80287478596 52013.613123331175 54203.136373428526 66846.83018429094 81586.34097679071 82868.43380019818 67565.17323726116 61106.249496412114 1.3734013537796694 1.0806216653840128 1.1340706301874226 0.8511995671798706 0.8870309799754785 1.0939442485046622 1.3351554325320047 1.3561368024241751 1.1056998882123878 1.0 15.899032315344929 -7.059320512737671 8.761044510920451 1.227351039957947 1.0513809537121375 0.11820533436674019 0.16528028600002653 0.7055331967977718 99.09305580209421 0.06565011243438595 0.050986842148926625 8.723273463396742e-08 7.059320512737671 -0.17597008624580956 QTQSESSNYDS(ph)ELEK ddPTM_A459_Selumetinib_30min_R1 1 QTQSESSNYDSELEK 15 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 QTQSESS(0.002)NYDS(0.998)ELEK 309.45 1.776799999999999e-94 5116200.0 672.17 1114.3 620.68 533.86 533.99 539.34 806.75 839.12 388.05 915.42 True False 687.8302531848586 983.8372379759846 536.3950651511947 440.63137279334455 485.6906987835915 533.914729281539 745.8961979818489 816.8638117541024 658.4925079493634 1032.923073945899 0.6659065621966006 0.952478710943691 0.5192981730014962 0.4265868232665924 0.47020994209006345 0.5168968945982745 0.7221217308394802 0.7908273446090981 0.6375039192742953 1.0 10.0125170993982 -8.91476052501913 0.727583566792679 0.9989022964072737 0.6060171815298269 0.3588348818789915 0.15031524156565335 1.6843925126807338 1.619950980034774 0.17732306474364554 0.061522027837755525 1.2168568045464238e-09 8.91476052501913 -0.3928851148774468 QTQSESSNYDS(ph)ELEK ddPTM_A459_Selumetinib_30min_R2 3 QTQSESSNYDSELEK 15 0 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 QTQS(0.002)ES(0.048)S(0.163)NYDS(0.788)ELEK;QTQSES(0.014)S(0.008)NYDS(0.978)ELEK;QTQSESS(0.001)NYDS(0.999)ELEK 244.18 1.4734e-20 15970500.0 65432.0 45822.6 62657.0 59900.0 57592.0 53613.0 60302.0 68957.0 49090.0 52961.0 True False 61795.55138504928 49337.04607711838 58625.71683578349 51741.5166667365 50356.77808098744 60997.70409964241 63106.16248614615 69157.6534535541 58909.371689202075 51431.8783207966 1.2015029083637823 0.9592697697989543 1.1398711995334234 1.0060203585023395 0.9790966172165942 1.185990208624713 1.2269853745673729 1.3446456888507228 1.1453863559437987 1.0 15.65037522222709 -6.871385354103518 6.764149523804916 1.2074732763158114 1.0538761893960351 0.23660988678612238 0.10593857794057873 0.25465259298922255 14.273632780232573 0.03587338459272087 0.031661966177095165 1.3446666875332534e-07 6.871385354103518 -0.15359708691977625 QTQSESSNYDS(ph)ELEKEIK ddPTM_A459_Selumetinib_30min_R1 1 QTQSESSNYDSELEKEIK 18 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 QTQSES(0.001)S(0.003)NYDS(0.996)ELEKEIK 83.245 0.004906499999999999 14744000.0 1327.7 1284.9 2299.4 2255.0 1478.5 1484.9 1487.2 1355.3 978.33 1245.8 True False 1358.6328267455222 1134.463310666196 1987.154109700097 1861.2065815925375 1344.7699360503766 1469.9632541813269 1375.0193066484114 1319.3530413651613 1660.1545556039196 1405.710565119618 0.9665096503204486 0.8070390440365366 1.4136296325915438 1.3240325766735341 0.9566478117321003 1.0457083347426086 0.9781667298853979 0.938566639607558 1.181007382883723 1.0 10.457083859689927 QTQSESSNYDS(ph)ELEKEIK ddPTM_A459_Selumetinib_30min_R2 1 QTQSESSNYDSELEKEIK 18 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 QTQS(0.049)ES(0.178)S(0.178)NY(0.114)DS(0.481)ELEKEIK 62.475 0.022958000000000003 5829600.0 9124.6 11502.0 8539.6 5779.6 6908.2 8009.9 3485.8 4555.6 2092.8 8235.0 True False 8617.49126066788 12384.166415240858 7990.17143321347 4992.408509633895 6040.330155908415 9113.1910183673 3647.896606981663 4568.856041779821 2511.4184777177043 7997.234152900431 1.07755895299658 1.548556185609418 0.9991168547085245 0.6242668920508289 0.7553024008578907 1.1395428524575757 0.4561447792120288 0.5713045228421618 0.314035881618755 1.0 12.96528541418285 -5.53782913788103 4.103120206191208 0.6902778801568742 1.312528389058362 0.4942827773042042 0.2512530434465706 0.1650021174015716 6.409837177571168 0.07008650330254564 0.13674668104732868 2.8984836981099646e-06 5.53782913788103 0.6222505089014879 QTS(ph)IETDR ddPTM_A459_Selumetinib_30min_R1 1 QTSIETDR 8 0 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 QT(0.035)S(0.959)IET(0.005)DR 102.05 0.01654 8188600.0 4868.2 4326.6 4729.8 5275.6 4484.6 4141.1 4486.0 4022.8 2328.9 3737.0 True False 4981.619588131771 3820.0396606182303 4087.51913893169 4354.315495276977 4078.968721820436 4099.444293817964 4147.617408300677 3916.102276104015 3951.9732038739126 4216.680351462524 1.1814079258827226 0.9059353193071127 0.969368981813849 1.0326406396365129 0.9673412214909 0.972197072608575 0.9836214895592232 0.9287168933129455 0.9372238050966324 1.0 12.041891945871614 -4.751255466554762 24.999996671991568 0.967031955880382 1.1814083649614335 0.779301690476651 0.034333983775920646 201.69817291946677 495105.6287914646 0.008809044951602776 0.11875996643754054 1.7731461501274313e-05 4.751255466554762 0.2143764090810515 QTS(ph)IETDR ddPTM_A459_Selumetinib_30min_R2 1 QTSIETDR 8 0 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 QT(0.036)S(0.964)IETDR 102.05 0.01654 27977000.0 193940.0 175730.0 260440.0 230710.0 263870.0 148780.0 165920.0 174000.0 167080.0 171300.0 True False 183161.59120333288 189207.92593899113 243683.57394563186 199286.90000305156 230720.2915722697 169273.0945096299 173635.60876424293 174506.3111927494 200500.6686052531 166354.123909149 1.1010342689392116 1.1373804357403443 1.4648484102426869 1.1979678971582823 1.3869225850888613 1.017546728219825 1.0437709909678619 1.0490050206873893 1.2052641911946382 1.0 17.343898105427854 -6.776737032199574 24.99339528788149 1.0649710214440504 1.2591476557511454 0.4228480790493736 0.11360730206138099 247.51082868436532 404382.1261154935 0.04059977297880354 0.03593629341673476 1.6721027756688797e-07 6.776737032199574 0.19417663430709498 QTS(ph)PDPCPQLPLVPR ddPTM_A459_Selumetinib_30min_R2 1 QTSPDPCPQLPLVPR 15 0 Q5D1E8;A0A1W2PQC8 Q5D1E8 ZC3H12A Ribonuclease ZC3H12A 1 QT(0.089)S(0.911)PDPCPQLPLVPR 116.87 0.0022066 3861600.0 28445.0 24474.0 28026.0 28974.0 32253.0 20306.0 22443.0 26109.0 22530.0 28284.0 True False 26864.140774357016 26351.077103686723 26222.837672401616 25027.69121706216 28201.089794521602 23102.96718048495 23486.64396996083 26184.972867422366 27036.629540796966 27467.367429342547 0.9780384248131067 0.9593593988019644 0.954690606584618 0.9111791030372225 1.0267125113852462 0.8411059865826369 0.8550744453533166 0.9533120687587178 0.9843181954130255 1.0 14.745431023540457 -5.171668456197933 0.9550366684169658 0.9310019330606594 0.9858603128389369 0.0329345224474652 0.056246395087870014 4.048601342164652 4.4186276964751965 0.021091126358444488 0.20197736742987726 6.73490608076369e-06 5.171668456197933 0.054858379778277566 QTSDNLS(ph)EECQLAR ddPTM_A459_Selumetinib_30min_R2 1 QTSDNLSEECQLAR 14 0 Q6ULP2-7;Q6ULP2-8;Q6ULP2-6;Q6ULP2;Q6ULP2-9;B8ZZI9;A0A0U1RR74 Q6ULP2-7 AFTPH Aftiphilin 1 QT(0.002)S(0.026)DNLS(0.972)EECQLAR 97.129 0.017791 0.0 8625.8 4238.2 6791.2 7985.9 7337.2 6146.6 4504.3 6579.5 6084.8 4555.1 True False 8146.412567813275 4563.256312039103 6354.261585699486 6898.206643554103 6415.435340599756 6993.238356720611 4713.758875101127 6598.645255705142 7301.930023517149 4423.582427428874 1.84158715282451 1.03157483485425 1.4364514937710302 1.5594163230193403 1.4502805013466449 1.580899298577172 1.065597612892434 1.491697140035092 1.6506824826504387 1.0 12.110999490688947 -10.694150946097867 4.75059247145717 0.9999491913654572 1.4394258154251136 0.25170479151511016 0.23446204354577044 0.00012088206288535906 2.1087556865973526e-05 0.21750083122720237 0.052745618549421246 2.0223161676979378e-11 10.694150946097867 0.4394766240596564 QTTFLGS(ph)PGPR ddPTM_A459_Selumetinib_30min_R1 1 QTTFLGSPGPR 11 0 E9PNH0;H0YCD7;Q9H0X9-3;Q9H0X9-2;Q9H0X9 E9PNH0 OSBPL5 Oxysterol-binding protein;Oxysterol-binding protein-related protein 5 1 QTT(0.01)FLGS(0.99)PGPR 91.307 0.026602 4732800.0 1204.1 1221.9 1158.4 1005.1 1041.7 914.46 1148.5 1105.0 633.22 873.52 True False 1232.1531872292558 1078.8393799541016 1001.0956426357287 829.5781530637072 947.4784189270723 905.261362663248 1061.8677203373459 1075.6918104541453 1074.5280914410407 985.6448008053367 1.250098601669187 1.0945518903692475 1.015675872096893 0.8416603551156433 0.9612777525462723 0.9184458355825443 1.0773330508817478 1.0913584788102513 1.090177811076648 1.0 9.944924022543287 -4.8730302271371855 2.249867310153568 0.9960775325037904 1.2858964583348833 0.5162951557903934 0.0748471470605783 0.44989768881480297 3.1764133927490783 0.02255401041276479 0.24436114767999392 1.3395834484290977e-05 4.8730302271371855 0.2898189258310929 QVAAS(ph)PAVGQPLQK ddPTM_A459_Selumetinib_30min_R2 2 QVAASPAVGQPLQK 14 0 Q92547;A0A2R8YD63 Q92547 TOPBP1 DNA topoisomerase 2-binding protein 1 1 QVAAS(1)PAVGQPLQK;QVAAS(1)PAVGQPLQK 120.77 0.0020184 6699600.0 61430.0 53465.0 52783.0 65418.0 63173.0 61530.0 63313.0 63076.0 54084.0 63923.0 True False 58015.966523773975 57565.59358292924 49386.999245785155 56507.955547655554 55236.642966214415 70005.19898627192 66257.17995232942 63259.54071720606 64902.31123322079 62077.376898100134 0.9345750323665745 0.9273200070522153 0.795571619059449 0.9102825920047045 0.8898031090599274 1.1277087158689918 1.067332146799476 1.0190433919436777 1.0455066640421644 1.0 15.921779976764313 -6.74453715813281 24.924335908087397 1.0540717580872954 0.8892127932566871 0.7403290660289283 0.04748178437330385 119.71281965571089 176530.36115625594 0.016106967065026692 0.016065838509712937 1.8007890527664062e-07 6.74453715813281 -0.16485896483060825 QVAEQGGDLS(ph)PAANR ddPTM_A459_Selumetinib_30min_R1 2 QVAEQGGDLSPAANR 15 0 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 QVAEQGGDLS(1)PAANR;QVAEQGGDLS(1)PAANR 233.48 3.2054e-14 268800000.0 5494.0 5102.0 5981.0 6300.1 6578.9 5253.0 5910.7 5535.4 3099.5 4549.2 True False 5621.99951053694 4504.655468144551 5168.813051281327 5199.90580252379 5983.839656599135 5200.159589342386 5464.851140268132 5388.583210486768 5259.625121476748 5133.13413296048 1.0952372108177333 0.8775643401210986 1.0069507083580278 1.0130079728746149 1.165728286384759 1.0130574137838182 1.064622703930072 1.0497647384443 1.0246420579006603 1.0 12.325624244495307 -5.887228057646339 3.6352876578427322 1.0562212122207348 0.9813133075399706 0.13291638813347662 0.06553279616471834 0.36403025100466907 9.224641536935426 0.018211082127494498 0.028406999023376237 1.2964982722527638e-06 5.887228057646339 -0.07490790468076425 QVAEQGGDLS(ph)PAANR ddPTM_A459_Selumetinib_30min_R2 5 QVAEQGGDLSPAANR 15 0 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 QVAEQGGDLS(1)PAANR;QVAEQGGDLS(1)PAANR;QVAEQGGDLS(1)PAANR;QVAEQGGDLS(1)PAANR;QVAEQGGDLS(1)PAANR 172.26 4.0246e-05 437240800.0 259738.0 230383.0 243487.0 265712.0 284332.0 237960.0 228893.0 236938.0 199210.0 234545.0 True False 245302.80177359626 248052.63530189867 227821.31150860107 229521.56722123385 248611.67219966906 270736.8300141926 239536.97804287475 237627.45035280244 239057.5663924622 227773.07642890522 1.0769613582936464 1.089034047355124 1.0002117681354272 1.007676459482139 1.091488406344936 1.188625250441738 1.051647463336789 1.0432639980036142 1.0495426858190555 1.0 17.79723769998121 -8.546907343366295 1.340259102340303 1.0018354181282294 1.070999717657891 0.1569936036850078 0.049476477423026965 1.0364188999228319 4.083338086644928 0.0520688022370202 0.015759192311954273 2.8385245624449477e-09 8.546907343366295 0.06916429952966152 QVAGDAPVEQATAET(ph)ASPVHR ddPTM_A459_Selumetinib_30min_R2 1 QVAGDAPVEQATAETASPVHR 21 0 Q92766;Q92766-2;A0A087X055;Q92766-4 Q92766 RREB1 Ras-responsive element-binding protein 1 1 QVAGDAPVEQATAET(0.777)AS(0.223)PVHR 149.82 4.6989999999999985e-06 3616500.0 32350.0 25365.0 30762.0 25694.0 26809.0 24979.0 26889.0 32829.0 28401.0 25857.0 True False 30552.116507310584 27310.413938670157 28782.806411133184 22194.432875377748 23441.013744499116 28419.630513214484 28139.39177954269 32924.52695486648 34081.993590243 25110.441225445848 1.2167096640400876 1.0876118700373514 1.1462485327404728 0.8838726757571611 0.933516601084054 1.131785389912434 1.1206251426210478 1.3111887066923449 1.3572837404269011 1.0 14.61599975854397 -7.4722332841828605 2.559862663559972 1.2475370239655688 1.0557622216485059 0.21247194136307745 0.1282959215786951 0.382011104562495 4.947376303193335 0.06883595542161497 0.03914373736800003 3.371061811785808e-08 7.4722332841828605 -0.1917748023170629 QVDLESNPQNRS(ph)PESR ddPTM_A459_Selumetinib_30min_R2 2 QVDLESNPQNRSPESR 16 1 J3QS41;P42694 J3QS41 HELZ Probable helicase with zinc finger domain 1 QVDLES(0.048)NPQNRS(0.945)PES(0.007)R;QVDLESNPQNRS(0.94)PES(0.06)R 75.998 0.016495 16293000.0 44755.0 38905.0 58359.0 56337.0 61382.0 52413.0 54939.0 53586.0 49725.0 40324.0 True False 42267.69626846012 41888.888400708194 54604.24547647491 48663.80341325428 53670.64439795755 59632.414992157865 57493.77235956321 53741.926388360145 59671.389432584554 39159.741345665694 1.0793660738297604 1.0696926731704415 1.394397501109099 1.242699817235655 1.3705566623692207 1.522799000784466 1.4681857025576799 1.3723769499388803 1.52379426886049 1.0 15.257083615365476 -5.209501686347335 1.2472199365476098 1.3968230032348898 0.9995014486296442 0.3321611991523922 0.1511180836313748 0.7667784289644495 1.6826072763617799 0.045274283841038127 0.3226649412195273 6.173028949226708e-06 5.209501686347335 -0.39732155460524565 QVDLESNPQNRS(ph)PESRPSVVYPSTK ddPTM_A459_Selumetinib_30min_R1 1 QVDLESNPQNRSPESRPSVVYPSTK 25 2 J3QS41;P42694 J3QS41 HELZ Probable helicase with zinc finger domain 1 QVDLES(0.105)NPQNRS(0.593)PES(0.259)RPS(0.042)VVY(0.001)PSTK 88.986 7.057600000000001e-05 5767300.0 426.45 349.41 493.8 469.29 623.34 399.66 377.95 339.25 304.59 465.12 True False 436.3854552727482 308.5009147636981 426.7446722492428 387.33731116432904 566.9590070596157 395.63978326224606 349.44092721070916 330.251987960696 516.8669836265857 524.8226826524617 0.831491224935724 0.5878193244326443 0.8131216244169722 0.7380346238213646 1.0802867821836442 0.7538541994082204 0.665826647287098 0.6292639378534431 0.9848411677146502 1.0 9.035686263852382 -8.321411184951314 10.838873968932567 0.993220351105861 0.7646295766337814 0.33651568519587627 0.12913029923687097 1.153555839944786 204.00618864238294 0.12936643684272778 0.03345468394031167 4.770773684727264e-09 8.321411184951314 -0.22859077447207965 QVETEEAGVVTT(ph)ATASVNLKVSPK ddPTM_A459_Selumetinib_30min_R1 1 QVETEEAGVVTTATASVNLKVSPK 24 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QVETEEAGVVT(0.105)T(0.412)AT(0.075)AS(0.112)VNLKVS(0.295)PK 78.942 0.00041695 22259000.0 2397.9 3195.8 4255.3 3339.8 2575.9 2934.5 2780.7 3071.1 2211.8 2897.1 True False 2453.7664044988232 2821.6342503128867 3677.453632689755 2756.5666258105334 2342.910299812083 2904.981594312819 2570.9495602455863 2989.644451661291 3753.263056519523 3268.9710051437196 0.7506234838540404 0.8631567076835649 1.1249575560331642 0.8432520880341493 0.7167118631904407 0.8886532152600425 0.786470591571538 0.9145521471304245 1.1481481636312378 1.0 11.674620865523497 -8.09947987656379 5.1972910844820515 1.0698260002152602 0.8592710078142578 0.384777311051298 0.10974475764498762 0.2517780501057912 10.226563306354933 0.08108998997969022 0.029561813587147583 7.952801147188132e-09 8.09947987656379 -0.2105549924010024 QVETEEAGVVTT(ph)ATASVNLKVSPK ddPTM_A459_Selumetinib_30min_R2 1 QVETEEAGVVTTATASVNLKVSPK 24 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QVETEEAGVVT(0.031)T(0.318)AT(0.268)AS(0.268)VNLKVS(0.114)PK 55.302 0.021338 4878700.0 12554.0 10730.0 13062.0 9988.0 10740.0 8177.8 10543.0 8787.6 6978.3 11702.0 True False 11856.298937643798 11552.956497612093 12221.605140830296 8627.617169738964 9390.745183181782 9304.217719322844 11033.270390558175 8813.170461134505 8374.154989993058 11364.13285455262 1.0433087231019136 1.0166157546269645 1.0754542645050267 0.7591971407024363 0.8263494719194282 0.81873538776832 0.9708853752214014 0.7755251169563575 0.736893443360112 1.0 13.472199982388402 -5.754065553775962 24.999720641962174 0.8355938784062401 1.0422752445016483 0.5667719137908693 0.08163926340416501 120.41494648512854 408241.97633150424 0.02199938115294073 0.03714349354842343 1.7617101082729579e-06 5.754065553775962 0.20668136609540821 QVETEEAGVVTTATAS(ph)VNLKVSPK ddPTM_A459_Selumetinib_30min_R1 2 QVETEEAGVVTTATASVNLKVSPK 24 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QVETEEAGVVT(0.166)T(0.166)AT(0.166)AS(0.465)VNLKVS(0.038)PK;QVETEEAGVVT(0.001)T(0.002)AT(0.007)AS(0.761)VNLKVS(0.229)PK 119.22 8.2535e-08 104382000.0 5398.700000000001 6237.2 7853.0 7070.9 5738.7 5423.299999999999 5775.2 5776.6 4208.8 5819.0 True False 5524.479205958459 5506.945724404386 6786.605733441277 5836.10005223178 5219.6355982497735 5368.746525962417 5339.572014359807 5623.385802958748 7142.026201410331 6565.925331859892 0.8413862367809735 0.8387158619795734 1.033609946873836 0.8888465459564739 0.794958110918882 0.8176679225868752 0.8132246019385203 0.8564498556924411 1.0877410022856977 1.0 12.680782628242191 -8.253838421248618 24.760760514487618 1.0438705050923738 0.8613866683777973 0.5506547001856996 0.06621644068292068 366.70876800830877 1194595.8053440743 0.0505498593276031 0.018312123202670262 5.573930878024233e-09 8.253838421248618 -0.18248383671457646 QVETEEAGVVTTATAS(ph)VNLKVSPK ddPTM_A459_Selumetinib_30min_R2 1 QVETEEAGVVTTATASVNLKVSPK 24 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QVETEEAGVVT(0.083)T(0.266)AT(0.193)AS(0.455)VNLKVS(0.003)PK 54.26300000000001 0.0092781 7286900.0 8453.1 8100.3 9067.8 10419.0 6913.0 4641.2 7144.3 7558.3 5957.9 8678.2 True False 7983.310542440402 8721.566963430316 8484.387620274145 8999.914226222496 6044.527136995873 5280.483171381205 7476.524106161882 7580.293401656073 7149.646477634902 8427.637817328537 0.9472773647231815 1.0348768127526096 1.006733773350929 1.0679047226872125 0.717226732806123 0.6265674066490741 0.8871434995449119 0.8994564747514194 0.8483571117560503 1.0 13.040912599485123 -6.252916405584327 24.967262894556875 0.8174710518764433 1.015142048838248 0.44612653271908376 0.10009467658884903 584.365458900099 1711843.5714565117 0.03127850787291661 0.03974369025361485 5.585777012442193e-07 6.252916405584327 0.1976709969618048 QVETEEAGVVTTATASVNLKVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 7 QVETEEAGVVTTATASVNLKVSPK 24 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QVETEEAGVVT(0.066)T(0.102)AT(0.236)AS(0.18)VNLKVS(0.417)PK;QVETEEAGVVT(0.002)T(0.009)AT(0.015)AS(0.181)VNLKVS(0.793)PK;QVETEEAGVVT(0.026)T(0.026)AT(0.01)AS(0.034)VNLKVS(0.905)PK;QVETEEAGVVT(0.002)T(0.008)AT(0.008)AS(0.019)VNLKVS(0.963)PK;QVETEEAGVVTT(0.017)ATAS(0.013)VNLKVS(0.969)PK;QVETEEAGVVTTATASVNLKVS(1)PK;QVETEEAGVVT(0.049)T(0.049)AT(0.066)AS(0.247)VNLKVS(0.589)PK 118.97 8.257199999999999e-08 135276200.0 8273.150000000001 9172.400000000001 12507.77 10768.169999999998 8694.029999999999 8149.129999999999 8664.279999999999 9015.669999999998 6456.540000000001 8572.779999999999 True False 8465.898298252407 8098.491143866926 10809.283534262675 8887.711253085283 7907.656521555666 8067.157151018027 8010.726383948156 8776.545144576588 10956.276812976115 9673.17981894859 0.8751929000294955 0.8372108546977448 1.1174488365334214 0.9187993420400735 0.8174826344141274 0.833971589695401 0.8281378547575545 0.9073071429298147 1.1326447991294541 1.0 13.23977450269205 -8.19141644103197 7.089449967369345 1.0654393740521824 0.8914341274879184 0.38819113512584724 0.08762967653491416 0.2574501172259689 22.327359875094686 0.06422030601995224 0.023815512865445195 6.435518735135712e-09 8.19141644103197 -0.17400524656426397 QVETEEAGVVTTATASVNLKVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 11 QVETEEAGVVTTATASVNLKVSPK 24 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 QVETEEAGVVT(0.009)T(0.01)AT(0.009)AS(0.024)VNLKVS(0.947)PK;QVETEEAGVVT(0.013)T(0.038)AT(0.142)AS(0.102)VNLKVS(0.706)PK;QVETEEAGVVT(0.003)T(0.008)AT(0.013)AS(0.111)VNLKVS(0.865)PK;QVETEEAGVVT(0.008)T(0.124)AT(0.073)AS(0.042)VNLKVS(0.754)PK;QVETEEAGVVT(0.065)T(0.065)AT(0.031)AS(0.087)VNLKVS(0.753)PK;QVETEEAGVVTTATAS(0.014)VNLKVS(0.986)PK;QVETEEAGVVT(0.043)T(0.098)AT(0.013)AS(0.018)VNLKVS(0.828)PK;QVETEEAGVVT(0.01)T(0.359)AT(0.127)AS(0.127)VNLKVS(0.376)PK;QVETEEAGVVT(0.006)T(0.006)AT(0.006)AS(0.022)VNLKVS(0.961)PK;QVETEEAGVVT(0.002)T(0.003)AT(0.002)AS(0.004)VNLKVS(0.989)PK;QVETEEAGVVTTATAS(0.003)VNLKVS(0.997)PK 111.38 1.0669e-05 48571500.0 178235.5 160352.19999999998 161166.99999999997 164933.9 128617.40000000001 101316.2 147931.3 147827.3 111933.4 132944.5 True False 168329.88444323812 172650.69812641118 150797.69068536177 142469.61829315283 112459.33235785521 115271.58689310792 154810.39857031006 148257.45296887288 134323.20768050815 129106.04685370626 1.3038110030119465 1.3372781704178938 1.1680141585950263 1.1035084859703683 0.8710616977164988 0.8928442137472108 1.1990948707904452 1.1483385680367677 1.0404098874835321 1.0 16.978197047208617 -5.5512268963034535 2.199789466713698 1.0341599791139433 1.322448799800849 0.5864664284501684 0.09605119034913183 0.24859637106986057 2.3848144451261333 0.03145166759568187 0.07471705399746113 2.8104321419946884e-06 5.5512268963034535 0.28828882068690564 QVHPDT(ph)GISSK ddPTM_A459_Selumetinib_30min_R1 1 QVHPDTGISSK 11 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 1 QVHPDT(0.96)GIS(0.028)S(0.012)K 145.49 0.001639 5241400.0 2652.8 3747.1 4073.7 4573.4 5252.6 3338.5 5326.6 5007.1 1441.2 2902.7 True False 2714.6050785497637 3308.3877900204716 3520.513915232361 3774.741543350467 4777.503257421848 3304.9177211154697 4924.810273529735 4874.295442647017 2445.6111389166913 3275.289819692339 0.8288137013794882 1.010105356212795 1.074870960751515 1.152490848490789 1.4586505379455603 1.0090458869456365 1.5036257994391296 1.4882027884496887 0.746685415199812 1.0 11.67740685632996 -5.162480200301799 1.2207363584867372 1.2318743406124113 0.7964383369316983 0.1859426153454451 0.23230717677059778 1.2619075007852107 2.5096757577126745 0.072190506079778 0.58715524783126 6.878912728940758e-06 5.162480200301799 -0.435436003680713 QVHPDTGIS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 QVHPDTGISSK 11 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 1 QVHPDT(0.005)GIS(0.915)S(0.079)K 187.62 1.9346e-05 37512000.0 4033.8 7364.2 8119.8 9018.6 7413.8 7167.7 8146.7 7990.7 2390.2 6527.1 True False 4127.7796915915405 6501.996040476298 7017.175758868774 7443.67081008889 6743.223099012704 7095.599445750891 7532.187860054203 7778.76067854836 4055.994826699053 7364.916864337979 0.5604652119807166 0.8828335961210816 0.9527841098718957 1.0106931208052394 0.9155871306116694 0.9634323885051355 1.0227118647497808 1.0561912404217724 0.5507183450146983 1.0 12.846453524779388 -4.7555376933453335 3.2452008829221097 0.941652919556016 0.4932610396461857 0.40442757592900624 0.13491446223403544 0.35811795781883554 5.538761636791959 0.03299882718057418 0.42376953108429033 1.7557485024248647e-05 4.7555376933453335 -0.44839187990983037 QVHPDTGIS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 QVHPDTGISSK 11 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 1 QVHPDT(0.003)GIS(0.874)S(0.123)K 155.09 0.00053142 16038000.0 69834.0 62931.0 69479.0 51920.0 51424.0 43298.0 52653.0 53132.0 39954.0 56957.0 True False 65952.90584765152 67757.60534494193 65008.796783015445 44848.4064330043 44963.657383607104 49261.9064798895 55101.468829940204 53286.60532352387 47945.91640803385 55312.50341794168 1.1923688455991746 1.2249961791272574 1.1753002081972044 0.8108185972731953 0.8129022301496892 0.8906106835857016 0.9961846856504234 0.9633735960365035 0.8668187741522771 1.0 15.755318018781326 -5.705736013686584 7.447669910399668 0.9037543075447871 1.2031692115496326 0.8135374154528975 0.06401472104944665 0.09853269226583497 11.002211910239797 0.018945853771152852 0.03277375779299561 1.969082834881304e-06 5.705736013686584 0.2994149040048455 QVHPDTGISSK ddPTM_A459_Selumetinib_30min_R1 5 QVHPDTGISSK 11 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 0 ;;;; 177.57 0.00075879 135798700.0 44205.100000000006 35694.5 46207.9 44583.8 53122.5 40058.7 51386.3 48821.3 21635.7 35746.5 False True 45234.99282184868 31515.371346077143 39933.12098182621 36798.07627157664 48317.579254539116 39655.745848389444 47510.19001965251 47526.40053006783 36714.20269099354 40334.91147539609 1.1214848667621744 0.7813422713299177 0.9900386419884677 0.9123133019400108 1.1979096392466952 0.983161841636347 1.1778925075522546 1.1782944053083761 0.9102338730404516 1.0 15.299741469145772 -6.237317791822929 24.52982057391252 1.084091290376942 0.9419227097566963 0.20344096591119487 0.11803920253563903 858.2496762947911 872773.9992728577 0.033082274638256165 0.042685450787139284 5.790048587888639e-07 6.237317791822929 -0.14216858062024562 QVHPDTGISSK ddPTM_A459_Selumetinib_30min_R2 3 QVHPDTGISSK 11 0 U3KQK0;Q99879;Q99877;Q93079;Q5QNW6;P62807;P58876;P57053;O60814;Q5QNW6-2;Q99880;Q96A08;Q16778;P33778;P23527;P06899;Q8N257 U3KQK0;Q16778 HIST1H2BN;HIST1H2BM;HIST1H2BH;HIST2H2BF;HIST1H2BC;HIST1H2BD;H2BFS;HIST1H2BK;HIST1H2BL;HIST1H2BA;HIST2H2BE;HIST1H2BB;HIST1H2BO;HIST1H2BJ;HIST3H2BB Histone H2B;Histone H2B type 1-M;Histone H2B type 1-N;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-D;Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-L;Histone H2B type 1-A;Histone H2B type 2-E;Histone H2B type 1-B;Histone H2B type 1-O;Histone H2B type 1-J;Histone H2B type 3-B 0 ;; 166.11 0.00086261 193090900.0 1841390.0 1417316.0 1940480.0 2377360.0 2278350.0 1745640.0 1913970.0 1890950.0 1857740.0 1760770.0 False True 1739052.915468212 1526019.5798107747 1815631.6294348752 2053559.466825252 1992123.3042925713 1986086.0646578227 2002973.3974596038 1896452.351436376 2229339.909592553 1709931.995070126 1.0170304552941545 0.8924446025984742 1.061815109998228 1.2009597298289243 1.165030720540949 1.1615000306350614 1.171376056611807 1.1090805698144743 1.3037593986310114 1.0 20.7055075188061 -5.524839738306622 4.280043261363821 1.163470171694828 0.9565496551858549 0.5311134960502202 0.07675082054517732 0.13376487196276782 5.931299982715092 0.019339469958136322 0.03809462989504182 2.986484476715368e-06 5.524839738306622 -0.20692051650897303 QVLQSTQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 QVLQSTQSPR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5 Q9Y2D5-5 AKAP2 A-kinase anchor protein 2 1 QVLQS(0.001)TQS(0.999)PR;QVLQS(0.068)T(0.015)QS(0.917)PR 146.5 0.00086038 93970000.0 54147.0 56049.0 64215.0 63588.0 68713.0 58314.0 52991.0 61068.0 66398.0 84898.0 True False 51137.72650761502 60347.77807405969 60083.476812005625 54927.20470458163 60080.658637985995 66346.22417821325 55455.186499674455 61245.69776964834 79679.4553151282 82446.77414850527 0.6202513929229593 0.7319604520288412 0.7287547321594622 0.6662141153715162 0.728720550421623 0.8047158286473247 0.6726180262648862 0.7428513535208909 0.9664350866124549 1.0 16.331175426747684 -8.26348649311062 3.6211912451350297 0.9983312832472628 0.7118080319001133 0.8461298658692655 0.04654890614401369 0.08192988756942841 2.2391539355871437 0.04117761502500689 0.011996026872171772 5.451468499077754e-09 8.26348649311062 -0.2865232513471495 QVLTAPGSAGQPRS(ph)EDEDSLEEAGSPAPGPCPR ddPTM_A459_Selumetinib_30min_R1 2 QVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPR 33 1 Q8TBB5-2;Q8TBB5-3;Q8TBB5 Q8TBB5-2 KLHDC4 Kelch domain-containing protein 4 1 QVLT(0.002)APGS(0.124)AGQPRS(0.872)EDEDS(0.002)LEEAGSPAPGPCPR;QVLT(0.005)APGS(0.142)AGQPRS(0.835)EDEDS(0.016)LEEAGS(0.001)PAPGPCPR 78.607 4.1758e-06 20795900.0 853.14 769.8299999999999 1868.6100000000001 1919.25 1062.87 1212.33 1186.97 838.79 490.22 720.85 True False 873.0165020785375 679.6979457157429 1614.8630255400103 1584.089016284469 966.7335961649396 1200.1350609075682 1097.4358972649711 816.5425644260927 831.8675357478081 813.3781191736048 1.0733218431859535 0.8356481809546568 1.9853780025220216 1.9475431892536146 1.1885414340222782 1.4754946470983383 1.3492321361926605 1.0038904971475051 1.0227316375230115 1.0 9.667782370906309 -7.7035985218334435 3.9018382940920744 1.0044214095512138 1.429450219371673 0.23128770687246913 0.33442101379163375 0.36317603727140896 11.125003097214542 0.19489427278849744 0.10134600186815773 1.9787980702678527e-08 7.7035985218334435 0.4250288098204591 QVLTAPGSAGQPRS(ph)EDEDSLEEAGSPAPGPCPR ddPTM_A459_Selumetinib_30min_R2 1 QVLTAPGSAGQPRSEDEDSLEEAGSPAPGPCPR 33 1 Q8TBB5-2;Q8TBB5-3;Q8TBB5 Q8TBB5-2 KLHDC4 Kelch domain-containing protein 4 1 QVLT(0.011)APGS(0.451)AGQPRS(0.476)EDEDS(0.061)LEEAGS(0.001)PAPGPCPR 60.03100000000001 0.00037261 6021400.0 7132.1 9069.1 8399.9 8712.1 9929.3 5584.4 4412.5 4324.7 3857.0 9766.1 True False 6735.726434058416 9764.67080824733 7859.4595791196125 7525.496950789233 8681.892564931743 6353.600409864081 4617.689993202874 4337.284161007371 4628.507773584284 9484.12731762489 0.7102104609604971 1.029580316799532 0.8286961273193723 0.7934833325997402 0.9154129077113601 0.66991935020282 0.48688612442196544 0.457320322234303 0.48802674390324413 1.0 13.211299314760915 -6.9299412057405 4.266228071556334 0.5637880164670926 0.8592084967461426 0.3261072613452498 0.16544451065301286 0.20691098042187092 7.396902630670101 0.057582866013372994 0.049889446096495225 1.1750566219104833e-07 6.9299412057405 0.29542048027905 QVPGGGGGGGS(ph)GGGGGSGGGGSGGGR ddPTM_A459_Selumetinib_30min_R2 1 QVPGGGGGGGSGGGGGSGGGGSGGGR 26 0 K7EN53;K7EQC2;Q9UHB9-4;Q9UHB9-2;Q9UHB9 K7EN53 SRP68 Signal recognition particle subunit SRP68 1 QVPGGGGGGGS(1)GGGGGSGGGGSGGGR 107.85 2.826e-08 1117100.0 2848.4 2239.0 482.05 3276.2 2391.6 2479.8 2091.5 2255.1 1200.8 2904.2 True False 2690.097331048638 2410.7241004802886 451.0354278163558 2829.975908239768 2091.145826824726 2821.3699406168903 2188.7588942286256 2261.6619676480987 1440.993553155304 2820.3481999822043 0.9538174510032527 0.8547611605175204 0.15992189468633758 1.0034136594402154 0.7414495227354979 1.0003622746420788 0.7760598121332807 0.8019087741231274 0.5109275348215502 1.0 11.461657573306178 -5.0070615008131565 24.55964900163993 0.744000271387077 0.9290536201692803 0.06629025468003025 0.24474967963284572 734.8443824997013 2555855.5726244366 0.06052438965605081 0.20280041216401895 9.838717689725794e-06 5.0070615008131565 0.18505334878220325 QVPGGGGGGGSGGGGGS(ph)GGGGSGGGR ddPTM_A459_Selumetinib_30min_R1 2 QVPGGGGGGGSGGGGGSGGGGSGGGR 26 0 K7EN53;K7EQC2;Q9UHB9-4;Q9UHB9-2;Q9UHB9 K7EN53 SRP68 Signal recognition particle subunit SRP68 1 QVPGGGGGGGS(0.001)GGGGGS(0.999)GGGGSGGGR;QVPGGGGGGGS(0.09)GGGGGS(0.806)GGGGS(0.104)GGGR 200.2 4.2179999999999997e-32 3455100.0 277.95 355.46000000000004 389.38 392.53 509.21000000000004 487.94000000000005 401.03999999999996 511.78000000000003 55.63399999999999 266.22 True False 284.425694203448 313.84257795112944 336.50433471123966 323.9820042006733 463.15204540832747 483.03176661407264 370.7892299208434 498.2059319042737 94.40683465340774 300.39193020239566 0.9468486520653533 1.0447769943076404 1.1202176253020928 1.0785309844454987 1.541825857626297 1.6080051361187346 1.234351500957486 1.6585196931508663 0.31427886424844725 1.0 8.230702246257524 -6.034368090048431 24.034991438625493 1.2814626078374465 1.0482544443167838 0.04197043530730393 0.36728055584290253 1025.296674228772 717029.6953240313 0.10608446826582904 0.1370485611181788 9.239147700317771e-07 6.034368090048431 -0.23320816352066265 QVPGGGGGGGSGGGGGS(ph)GGGGSGGGR ddPTM_A459_Selumetinib_30min_R2 1 QVPGGGGGGGSGGGGGSGGGGSGGGR 26 0 K7EN53;K7EQC2;Q9UHB9-4;Q9UHB9-2;Q9UHB9 K7EN53 SRP68 Signal recognition particle subunit SRP68 1 QVPGGGGGGGS(0.019)GGGGGS(0.973)GGGGS(0.008)GGGR 182.66 7.6418e-22 970670.0 709.51 985.78 0.0 2187.8 1246.2 927.31 1207.5 1335.9 1014.9 1276.7 True False 670.078274593568 1061.3861562177117 0.0 1889.8178658344918 1089.6412148306463 1055.0385352179396 1263.651142615858 1339.787247829849 1217.9083586753145 1239.838353735032 0.540456159123443 0.85606817454894 0.0 1.5242453664555438 0.878857482951778 0.8509484579498771 1.0192063657404125 1.080614455742331 0.982312214335318 1.0 10.275936323446382 -5.762438180447988 24.999999784319613 1.0349241112126861 0.5045642074939778 0.508422461984837 0.2614174709817513 22.774086395108686 570062.908184288 0.07055229348866437 0.11179803967986178 1.7280719450205365e-06 5.762438180447988 -0.5303599037187083 QVPGGGGGGGSGGGGGSGGGGS(ph)GGGR ddPTM_A459_Selumetinib_30min_R2 1 QVPGGGGGGGSGGGGGSGGGGSGGGR 26 0 K7EN53;K7EQC2;Q9UHB9-4;Q9UHB9-2;Q9UHB9 K7EN53 SRP68 Signal recognition particle subunit SRP68 1 QVPGGGGGGGSGGGGGSGGGGS(1)GGGR 162.35 2.6443e-14 938590.0 479.56 882.06 692.83 382.6 569.03 627.13 664.67 815.9 0.0 0.0 True False 452.9079750307837 949.7111657300765 648.2540720962678 330.48921997818655 497.54336420725616 713.5114649806716 695.5784720186188 818.2741339204837 0.0 0.0 0.0 QVQS(ph)LTCEVDALK ddPTM_A459_Selumetinib_30min_R2 1 QVQSLTCEVDALK 13 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QVQS(0.991)LT(0.009)CEVDALK 77.77600000000002 0.042433 1301000.0 5273.2 7451.4 9831.6 8413.0 9702.5 5171.6 6210.8 7668.8 6803.4 8333.8 True False 4980.136654292123 8022.898419972672 9199.04555983671 7267.13488676551 8483.585208549468 5883.940956889384 6499.614506466724 7691.114938361815 8164.270102878746 8093.181540187203 0.6153496779434566 0.9913157613151842 1.1366414449198092 0.8979330132013095 1.0482385902779632 0.7270244622182642 0.8030975796344713 0.9503203283123083 1.0087837598030576 1.0 12.982491241945016 -14.522878745252038 0.010138238021950791 2.020139802025551 8.445173901672384e-11 0.050597260663744814 0.14707082332856905 71458.21922524841 54.82498553150771 6363.59632339687 4680.683484152343 3.0000000001954847e-15 14.522878745252038 -2.0201398019410997 QVQS(ph)LTCEVDALKGTNESLER ddPTM_A459_Selumetinib_30min_R1 1 QVQSLTCEVDALKGTNESLER 21 1 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QVQS(0.989)LT(0.011)CEVDALKGTNESLER 70.907 0.0047779 7352500.0 2386.2 2130.6 3565.4 4243.6 3084.4 2772.0 2341.3 2556.0 1694.9 1968.7 True False 2441.793817263059 1881.1483615109319 3081.238263340318 3502.534922237736 2805.416564595049 2744.116196774624 2164.693856008556 2488.2065769418987 2876.1215094018194 2221.4018217619137 1.099213025460806 0.8468293953314991 1.3870692970335379 1.576722809860526 1.2629036931147926 1.2353083399373992 0.9744719909753294 1.1201064807664414 1.2947326689057148 1.0 11.117254665313542 -7.0566126355361165 23.43674629933328 1.1069868687149167 1.2413524877038837 0.10657955665485552 0.1935071537992542 409.41839830668107 169490.57511966088 0.08203866418243923 0.0635473167023062 8.777834018959225e-08 7.0566126355361165 0.13436561898896704 QVQSLT(ph)CEVDALK ddPTM_A459_Selumetinib_30min_R1 4 QVQSLTCEVDALK 13 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QVQS(0.261)LT(0.739)CEVDALK;QVQS(0.009)LT(0.991)CEVDALK;QVQS(0.008)LT(0.992)CEVDALK;QVQS(0.001)LT(0.999)CEVDALK 248.81 1.9257e-22 61068000.0 15293.2 19418.5 13481.3 13285.099999999999 14024.7 14842.499999999998 16943.5 16240.3 9562.1 15396.8 True False 15649.501804612946 17144.972992584266 11650.613507480177 10965.106677212865 12756.1683612619 14693.197925911745 15665.43815370989 15809.55448807101 16226.185311847972 17373.129257532284 0.9007877379274063 0.9868672901947645 0.6706111106857128 0.6311532317909188 0.7342470186095773 0.845742739152267 0.9017050366397287 0.910000395076588 0.9339817295616423 1.0 14.084570016022406 -7.215304325204635 2.2282958329096654 0.9369565932673265 0.7821100589200777 0.34049944704449786 0.09966206533436463 0.4437213757064906 4.314087589317629 0.054049252470108784 0.03646062533259137 6.09109923212993e-08 7.215304325204635 -0.15484653434724882 QVQSLT(ph)CEVDALK ddPTM_A459_Selumetinib_30min_R2 2 QVQSLTCEVDALK 13 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QVQS(0.004)LT(0.996)CEVDALK;QVQS(0.127)LT(0.873)CEVDALK 209.89 1.8307e-05 43583000.0 77433.0 63607.0 82203.0 84279.0 83061.0 66915.0 77081.0 74694.0 64808.0 70536.0 True False 73129.58384885866 68485.45237125935 76914.14847585931 72800.05481061563 72626.13460523855 76131.93385610908 80665.41923310394 74911.34717374262 77771.4108868163 68499.44240546264 1.0675938559614724 0.999795764261547 1.122843424338964 1.062783173908143 1.060244172140105 1.1114241398560314 1.1776069468657615 1.0936052111245893 1.1353583059329289 1.0 16.06380462394162 -6.771937156193414 8.52670542784802 1.1141575679665592 1.062478306849893 0.12459085835824857 0.050537567300336435 0.242516351193922 127.25442933123783 0.01681557476021244 0.015422451910965402 1.6906855615751027e-07 6.771937156193414 -0.0516792611166661 QVQSLT(ph)CEVDALKGTNESLER ddPTM_A459_Selumetinib_30min_R1 1 QVQSLTCEVDALKGTNESLER 21 1 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QVQS(0.033)LT(0.967)CEVDALKGTNESLER 158.12 2.0491e-07 24325000.0 1462.3 987.15 2129.0 2948.1 1858.6 1680.7 1309.8 1398.4 1053.5 1187.0 True False 1496.3687448595135 871.574019086416 1839.8934937598983 2433.2696776908915 1690.489958162481 1663.7936839535032 1211.0007314739696 1361.3098893566307 1787.7125554043394 1339.3630123591151 1.117224181235118 0.6507377096753261 1.3737078572292087 1.816736504769533 1.2621596554207517 1.2422275877418365 0.9041616949992878 1.016386055755608 1.334748338507209 1.0 10.387331317132775 -10.456449907510779 4.835292473787289 0.999998687149591 1.1888348770033472 0.03655531645838361 0.29383849061491024 224230053.71716937 35.050907017146926 3287.8038024298853 0.07750062653184926 3.495828289324909e-11 10.456449907510779 0.18883618985375628 QVQSLTCEVDALK ddPTM_A459_Selumetinib_30min_R2 3 QVQSLTCEVDALK 13 0 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 0 ;; 244.73 3.2246999999999984e-77 3871700.0 34408.6 30788.6 31312.5 32694.8 33832.8 29231.7 33363.3 32522.5 28041.2 26067.9 False True 32496.307760539312 33149.9866190475 29297.88784047224 28241.711838324147 29582.42119493041 33258.10133604755 34914.75955812475 32617.13509061027 33650.22353659105 25315.25199446185 1.2836651899672356 1.3094867325950235 1.1573215959644274 1.1156006602068393 1.168561197866096 1.3137574669737964 1.379198578223237 1.2884380964386937 1.3292470303654342 1.0 14.627719224822297 -6.7656461641953864 24.966818135883926 1.287472515996799 1.2047952829600774 0.03463108420387351 0.11054147311483423 245.07970032872052 1454509.1727306698 0.03793717383433642 0.03464172286991216 1.7153543010412955e-07 6.7656461641953864 -0.08267723303672159 QVQSLTCEVDALKGTNES(ph)LER ddPTM_A459_Selumetinib_30min_R1 1 QVQSLTCEVDALKGTNESLER 21 1 P08670;B0YJC4;B0YJC5 P08670;B0YJC5 VIM Vimentin 1 QVQSLTCEVDALKGT(0.361)NES(0.639)LER 60.951 0.010327 5390500.0 1391.3 1056.0 1628.3 1703.1 1441.0 1295.3 1127.2 1174.4 733.83 810.86 True False 1423.7145830014636 932.3630290789193 1407.1858036116685 1405.6855561464524 1310.661804429214 1282.2704580383006 1042.1743964860736 1143.2510970111748 1245.2559131773767 914.9417794452512 1.5560712331496023 1.0190408286352723 1.5380058438962918 1.53636612484649 1.4325084217095172 1.4014776533822388 1.1390608887900675 1.249534257474123 1.3610220247373577 1.0 9.8375361329769 -7.245935518366993 22.324084465037927 1.208198842334968 1.4080151351721142 0.30176471816562456 0.16745931023645907 288.2256561829043 415017.6001460768 0.06421886740886397 0.04948271897813018 5.676288775359192e-08 7.245935518366993 0.19981629283714608 QVRGPS(ph)QPRK ddPTM_A459_Selumetinib_30min_R2 1 QVRGPSQPRK 10 2 A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;H7BZQ3;Q96G74-4 A0A087WXV6 OTUD5 OTU domain-containing protein 5 1 QVRGPS(1)QPRK 105.46 0.014126 2137200.0 14330.0 17271.0 17036.0 18857.0 19431.0 13195.0 13844.0 13502.0 14214.0 18043.0 True False 13533.5959675351 18595.630164982158 15939.922307394336 16288.644069860591 16989.904064655995 15012.491477715885 14487.773431365578 13541.288584623562 17057.19717234301 17522.05170865605 0.7723750729972668 1.0612701340103767 0.9097063844138681 0.9296082639576879 0.9696298325762177 0.8567770331541471 0.8268308798682799 0.7728140979023618 0.9734703136343675 1.0 14.096884093792172 -6.774210623501742 24.88505184696705 0.86808260933935 0.9349085485813281 0.031469224617110436 0.09146998060440312 491.70447339096614 958090.6416109103 0.030602736633180624 0.02716433877061022 1.6818581981228662e-07 6.774210623501742 0.0668259392419781 QVS(ph)SPCAQR ddPTM_A459_Selumetinib_30min_R2 1 QVSSPCAQR 9 0 Q6NSI8-3;Q6NSI8;Q6NSI8-2 Q6NSI8-3 KIAA1841 Uncharacterized protein KIAA1841 1 QVS(0.5)S(0.5)PCAQR 141.71 0.0021829 3789400.0 34011.0 26155.0 39565.0 38441.0 52754.0 32558.0 41810.0 41537.0 36388.0 30619.0 True False 32120.804776820412 28161.00439841981 37019.4309751149 33205.269485576224 46126.570893256256 37042.56896790253 43754.24784494331 41657.86579317948 43666.6167656689 29734.94991228396 1.0802373930870763 0.9470674906631025 1.2449804383165148 1.1167084385051755 1.5512577296859904 1.2457585796234916 1.4714754177832923 1.4009731281225393 1.4685283444055697 1.0 14.859872025084975 -5.767322380365959 1.500870845711206 1.3729563729786842 1.0234804922958889 0.3606637100255037 0.162136364314611 0.38139073431676135 1.734461295821537 0.04957288493218226 0.11252689378736462 1.7087464276681872e-06 5.767322380365959 -0.34947588068279534 QVSS(ph)PSFTNR ddPTM_A459_Selumetinib_30min_R2 2 QVSSPSFTNR 10 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 QVS(0.225)S(0.774)PSFTNR;QVS(0.105)S(0.857)PS(0.038)FTNR 158.86 0.00046844 19214300.0 121845.0 100257.0 130703.0 146625.0 153203.0 114671.0 116513.0 126431.0 101796.0 103546.0 True False 115073.34268418113 107946.38952293528 122293.71127866633 126654.42205776692 133956.26948780252 130465.88937030386 121931.08536612951 126798.89327822132 122158.0444178858 100556.3579351825 1.1443666521649094 1.0734914404170874 1.2161708497586545 1.2595366882659667 1.3321511661564873 1.2974404806347573 1.2125646539896058 1.260973407170877 1.214821687323118 1.0 16.6176447770803 -5.3801496950617125 4.7927902546710675 1.2427293446819432 1.1099395050858103 0.20283184797860632 0.0865395493373156 0.26741432492532075 9.24133900758845 0.021683220709866908 0.04703934200781144 4.167257193503382e-06 5.3801496950617125 -0.13278983959613289 QVSS(ph)PYSQGESTCETQTK ddPTM_A459_Selumetinib_30min_R2 1 QVSSPYSQGESTCETQTK 18 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 QVS(0.116)S(0.873)PY(0.009)S(0.002)QGESTCETQTK 142.74 0.00029896 4696700.0 25666.0 21683.0 26134.0 23681.0 29373.0 20557.0 23283.0 20307.0 19055.0 23015.0 True False 24239.58646913858 23346.016378166183 24452.56689254777 20455.606947996435 25682.901142048297 23388.540152133806 24365.70563438924 20366.09000799517 22866.532441184492 22350.497149848616 1.0845211319741386 1.0445412565833825 1.0940502454422314 0.9152193264808423 1.1490975332610107 1.0464438439702546 1.0901639221279815 0.911214183355788 1.0230883137800526 1.0 14.44801930168038 -7.74708846418168 24.986413890466473 0.975363414045673 1.0585178475849095 0.2672647657511623 0.06246618115844981 290.67914521139915 506104.0074257132 0.028317847688656708 0.01625231794361543 1.7902411513828757e-08 7.74708846418168 0.08315443353923657 QVSS(ph)VNEEDFVR ddPTM_A459_Selumetinib_30min_R1 1 QVSSVNEEDFVR 12 0 P40189-3;P40189 P40189-3 IL6ST Interleukin-6 receptor subunit beta 1 QVS(0.172)S(0.828)VNEEDFVR 147.1 0.00063877 2576100.0 989.92 971.09 1230.3 836.12 1259.6 814.93 985.73 904.42 600.75 731.07 True False 1012.9832099509878 857.3943313525068 1063.2320175541574 690.1073379162533 1145.6694024004426 806.7325440972382 911.3755924842243 880.4318436298082 1019.4288729560112 824.9099557248343 1.2279924650211025 1.039379298797684 1.2889067590654955 0.8365850516495074 1.38884176927379 0.9779643687150995 1.1048182727815596 1.0673066042174115 1.2358062427071286 1.0 9.688092838200998 -9.015148482496246 0.011257916372182378 1.4090228921684257e-06 2.171135834201982 0.040414015450137786 0.1549413041998297 7999.974573749667 38.220806013648506 3785.5836016772782 3580.7456797732525 9.657206488489898e-10 9.015148482496246 2.17113442517909 QVSS(ph)VNEEDFVR ddPTM_A459_Selumetinib_30min_R2 2 QVSSVNEEDFVR 12 0 P40189-3;P40189 P40189-3 IL6ST Interleukin-6 receptor subunit beta 1 QVS(0.003)S(0.997)VNEEDFVR;QVS(0.002)S(0.998)VNEEDFVR 247.11 3.2388e-18 5541200.0 26683.0 14036.2 23139.0 24833.0 24298.9 17026.6 31427.0 23384.0 19842.3 18423.6 True False 25200.06568051215 15112.731406503526 21650.261931838322 21450.70256068558 21246.254947077825 19371.85959791416 32888.4177714191 23452.04356857041 23811.31444018446 17891.662797738496 1.40848092015782 0.8446800935916238 1.210075451152305 1.1989216878934776 1.1874947112105951 1.0827310919565711 1.8381979441047924 1.3107805481072863 1.3308608992560604 1.0 14.126999852941177 QVTMAEASEDS(ph)PRPSAPDMEDFGLVK ddPTM_A459_Selumetinib_30min_R1 1 QVTMAEASEDSPRPSAPDMEDFGLVK 26 1 F5H1D6;Q07864 F5H1D6 POLE DNA polymerase;DNA polymerase epsilon catalytic subunit A 1 QVT(0.001)MAEAS(0.23)EDS(0.744)PRPS(0.024)APDMEDFGLVK 51.966 0.012811 3007200.0 556.2 689.55 684.39 1127.9 768.15 596.85 840.62 620.25 436.12 481.13 True False 569.1583778231975 608.8171654369016 591.453597085174 930.9334383051983 698.6709681278975 590.846230896441 777.2113566129551 603.7989551440581 740.0637870554731 542.8877221030675 1.0483905873176893 1.1214421337038774 1.0894584147049218 1.7147807924240734 1.2869529732986933 1.0883396452724872 1.4316244869236536 1.1121985828027745 1.363198607971045 1.0 9.084510046157456 -11.846336501582078 1.8434087521366234 7.367819879995172e-05 1.253351691207022 0.126180807403397 0.1978173260242876 2838836.601673639 342705.27169857826 11794699.65730518 0.05081059191854216 1.4245034271212015e-12 11.846336501582078 1.253278013008222 QVVES(ph)AYEVIK ddPTM_A459_Selumetinib_30min_R1 2 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 QVVES(1)AYEVIK;QVVES(1)AYEVIK 151.22 0.00059971 11580000.0 2262.19 3597.8 3459.0 3893.3999999999996 3132.5 3154.42 2910.4700000000003 3130.8999999999996 1519.93 2516.7 True False 2314.8946255445153 3176.5679034281584 2989.2867989269525 3213.4907781695715 2849.1659280877952 3122.6893987842004 2690.9309046671597 3047.858361403515 2579.210198705002 2839.7429597339406 0.8151775207715987 1.1186110674347003 1.0526610476065845 1.1316132564584818 1.0033182469284958 1.0996380457887531 0.9475966461835252 1.073286703980093 0.9082548087192552 1.0 11.471544634286559 -7.914904657739412 1.4131987868490858 0.9688754882944312 1.0401979322523274 0.05220147603307468 0.09365395391580433 1.2197309633100635 4.39713290883642 0.07795216218956585 0.027413696283156933 1.2164530237292196e-08 7.914904657739412 0.07132244395789622 QVVESAYEVIK ddPTM_A459_Selumetinib_30min_R2 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 142.08 0.013166999999999998 5364000.0 23851.0 33266.0 33912.0 32797.0 35381.0 26408.0 25184.0 24360.0 25496.0 28111.0 False True 22525.4569031179 35817.395232950985 31730.138840593867 28329.992022019294 30936.122469846792 30045.462292044038 26355.105901149298 24430.8835669849 30595.912417761185 27299.36238885051 0.8251275829181144 1.3120231426203337 1.162303294437124 1.0377528829607283 1.1332177663783676 1.1005920894443704 0.9654110424173548 0.8949250615817628 1.1207555686449673 1.0 14.736579635120007 -7.251192578491066 19.80391017876616 0.9865166935883379 1.1071977462353062 0.12659519679668363 0.1253528067778521 74.70368379493551 144380.02122795006 0.04682903602937055 0.03563132656028507 5.607992465979469e-08 7.251192578491066 0.12068105264696827 QVVSVVQDEEVGLPFEASPES(ph)PPPASPDGVTEIR ddPTM_A459_Selumetinib_30min_R2 1 QVVSVVQDEEVGLPFEASPESPPPASPDGVTEIR 34 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 QVVSVVQDEEVGLPFEAS(0.003)PES(0.997)PPPASPDGVTEIR 127.78 3.6277999999999997e-25 5594800.0 17654.0 17264.0 19835.0 20795.0 18316.0 14267.0 15038.0 14887.0 14369.0 18420.0 True False 16672.861354561377 18588.093287490694 18558.837694715116 17962.68512662413 16014.980332882447 16232.149747068768 15737.2967972317 14930.318705324475 17243.201503404864 17888.166739092412 0.9320609315500659 1.039127908332198 1.0374924365031233 1.0041657923150316 0.8952834891617851 0.9074238843936634 0.8797601803900761 0.8346477826984964 0.9639445872182052 1.0 14.126717920547831 -6.256812106949368 21.579809179388405 0.9032505732648637 1.008225872927085 0.4166545056171943 0.05100225285154168 49.50944268326225 230888.7694924778 0.014831600245681135 0.018441368057500667 5.535895622564283e-07 6.256812106949368 0.1049752996622213 QVVSVVQDEEVGLPFEASPESPPPAS(ph)PDGVTEIR ddPTM_A459_Selumetinib_30min_R2 3 QVVSVVQDEEVGLPFEASPESPPPASPDGVTEIR 34 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 QVVSVVQDEEVGLPFEASPES(0.001)PPPAS(0.941)PDGVT(0.058)EIR;QVVSVVQDEEVGLPFEASPESPPPAS(0.98)PDGVT(0.02)EIR;QVVSVVQDEEVGLPFEAS(0.001)PES(0.007)PPPAS(0.631)PDGVT(0.361)EIR 131.16 2.3641e-25 8455060.0 51473.8 44836.94 51820.8 53457.55 55621.3 34651.4 48872.9 49660.9 51193.15 57771.3 True False 48613.09226194756 48275.78912451479 48486.70614622099 46176.5394705826 48633.65503326902 39424.31581590935 51145.586689814125 49805.404997195415 61433.21045612297 56103.29246113625 0.8664926803649308 0.8604804995706142 0.8642399406382183 0.8230629156492003 0.8668591966676183 0.7027094861361172 0.911632534315942 0.887744779536718 1.0950018753120212 1.0 15.775797818440056 -8.065709436866426 2.5880376036085506 1.0461888477685368 0.8384182529244918 0.6600212709798501 0.05734726571939764 0.1702528325758397 2.095394543586691 0.0459677212485894 0.015169183206173309 8.595884336579097e-09 8.065709436866426 -0.20777059484404503 QWEAGSAGAAS(ph)PEELASPEER ddPTM_A459_Selumetinib_30min_R2 1 QWEAGSAGAASPEELASPEER 21 0 O94819 O94819 KBTBD11 Kelch repeat and BTB domain-containing protein 11 1 QWEAGSAGAAS(1)PEELASPEER 201.95 2.263e-25 0.0 3330.3 2991.3 3955.5 3740.4 4866.1 3552.3 2700.5 3678.9 3389.0 3946.2 True False 3145.2152582471817 3220.723091454528 3701.0074364227708 3230.951067450103 4254.777014514048 4041.5970804312365 2826.078600939234 3689.6049899253208 4066.8946965717237 3832.2629525410653 0.8207201064221541 0.8404233037607604 0.9657498669209892 0.8430922166517176 1.1102518452427241 1.0546241556183842 0.7374438121646484 0.9627744848455265 1.06122537699953 1.0 11.903980840337352 -5.210173431013866 1.2764865312720692 0.968868930538879 0.7963284596464593 0.2207131199454171 0.10300998715521448 1.2733382163529194 2.9637410979872736 0.033848394158856994 0.23566394662007667 6.163488201769754e-06 5.210173431013866 -0.17254047089241975 QWLQEIDR ddPTM_A459_Selumetinib_30min_R2 1 QWLQEIDR 8 0 E7END7;P62820-2;P62820;E9PLD0;Q9H0U4;Q92928 E7END7 RAB1A;RAB1B;RAB1C Ras-related protein Rab-1A;Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C 0 163.15 0.0047835 3523900.0 14677.0 7289.4 12598.0 15740.0 10712.0 10788.0 15590.0 12882.0 11194.0 12684.0 False True 13861.311096686164 7848.473540884772 11787.458395665293 13596.18484698551 9366.262793504966 12273.949076286395 16314.965890998943 12919.484487270094 13433.112786492735 12317.779963010205 1.1253091984360104 0.6371662397325996 0.9569466601175336 1.1037853320821043 0.7603856231911492 0.9964416569499185 1.3245053848982629 1.0488484553277282 1.0905465779411412 1.0 13.588454641672971 -7.0071791196348325 24.588361888269045 1.1258212086625372 0.9102752219431812 0.2632974329503075 0.15665084987205188 339.74651797000973 1163628.4033628742 0.05508945344310811 0.04666567472611058 9.836053456721145e-08 7.0071791196348325 -0.215545986719356 QWTSLS(ph)LR ddPTM_A459_Selumetinib_30min_R2 1 QWTSLSLR 8 0 Q9UHB6;Q9UHB6-4;F8VRN8;F8VVQ7;F8VTU2 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 QWTS(0.001)LS(0.999)LR 86.189 0.034221 2814300.0 10060.0 8196.4 10352.0 9619.4 9920.0 6546.8 5651.4 6294.4 5042.1 8095.6 True False 9500.90547337077 8825.037524420108 9685.96359040539 8309.221125609427 8673.7609140748 7448.562274066715 5914.201298036653 6312.715661905988 6050.6608880449385 7861.858993105135 1.2084807781089795 1.1225128219877363 1.2320195005913994 1.0569028435763894 1.1032709848499833 0.9474301536823693 0.7522649926974547 0.8029545769572122 0.7696221584934784 1.0 12.940654773103278 -6.836764798955359 1.9508395079126146 0.8134358431631611 1.1561790487863204 0.7819291250684759 0.07845336705005088 0.13849016778900758 1.083207322177213 0.03135753477963434 0.027273744611330357 1.4562475276469656e-07 6.836764798955359 0.3427432056231593 QYAENYTRPSS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 QYAENYTRPSSR 12 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 QYAENYTRPS(0.064)S(0.936)R;QYAENYTRPS(0.235)S(0.765)R;QYAENYTRPS(0.033)S(0.967)R 119.62 0.020095 66569000.0 171403.0 156054.0 184170.0 201765.0 201056.0 156712.0 157311.0 179296.0 149750.0 173013.0 True False 161877.10744057337 168022.84000730253 172320.70270913493 174284.2589359614 175797.54781655472 178297.65551010304 164626.27320583284 179817.72167594926 179704.18436459595 168017.66514824075 0.9634529041797503 1.0000307994939532 1.025610625865427 1.0372972317059144 1.0463039565598644 1.0611839853434002 0.9798152656185544 1.0702310469396026 1.0695553006646312 1.0 17.358253398404926 -4.87310044567549 1.2911070869313908 1.039860894076038 0.9378198289464071 0.4229190879087189 0.027413788253253267 1.1253661904618495 1.8546267410683548 0.0082163254941324 0.14631741045477523 1.339366876513684e-05 4.87310044567549 -0.10204106512963096 QYPDS(ph)PHPVPHR ddPTM_A459_Selumetinib_30min_R2 1 QYPDSPHPVPHR 12 0 Q5VT52-2;Q5VT52-3;Q5VT52 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 QY(0.005)PDS(0.995)PHPVPHR 90.498 0.016092 5235400.0 29678.0 25369.0 27580.0 29808.0 31226.0 19471.0 23633.0 25692.0 21352.0 26270.0 True False 28028.61557044708 27314.720725808118 25805.532826833525 25748.098978331913 27303.110716018095 22152.953509860257 24731.98132790108 25766.759466460437 25622.996624726908 25511.51684234297 1.0986651928091682 1.0706819549228943 1.011524833521563 1.0092735425122301 1.0702268659581036 0.8683510920484231 0.9694437802636632 1.0100049960061106 1.004369782599477 1.0 14.638861059590127 -5.044781549257708 0.7836710904117026 0.9802684555679625 1.1447313230143266 0.4003858289979795 0.04710117271793176 2.0415369758629667 1.2388478869750046 0.020027428890742625 0.2743996642161454 9.020247432434639e-06 5.044781549257708 0.16446286744636407 QYQDS(ph)PNQK ddPTM_A459_Selumetinib_30min_R2 1 QYQDSPNQK 9 0 H0Y9T5;Q8IU60 H0Y9T5 DCP2 m7GpppN-mRNA hydrolase 1 QYQDS(1)PNQK 120.57 0.0037099 0.0 12739.0 8003.3 9664.0 14436.0 14731.0 11150.0 14585.0 15659.0 9686.8 14093.0 True False 12031.01737825747 8617.12737533447 9042.228761367625 12469.791896510973 12880.360083189102 12685.81129037758 15263.23139962923 15704.565097513007 11624.430671806134 13686.098471988558 0.8790684505800863 0.6296262877964243 0.6606871037698892 0.9111283191504862 0.9411272401372409 0.9269121741555292 1.1152361230535206 1.1474829827986157 0.8493604437815455 1.0 13.740423612315222 -6.079706259683216 1.7573364933711237 1.0171279569245368 0.7144534899861401 0.5667934463703035 0.10471575083502184 0.25000358519601606 1.5395516543551317 0.03598883587675352 0.05539197687528035 8.323265348670826e-07 6.079706259683216 -0.3026744669383967 QYSS(ph)LPR ddPTM_A459_Selumetinib_30min_R2 3 QYSSLPR 7 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 QYS(0.184)S(0.816)LPR;QYS(0.223)S(0.777)LPR;QYS(0.035)S(0.965)LPR 104.01 0.018263 105791200.0 489939.0 433477.0 494326.0 553597.0 574672.0 465926.0 409754.0 487686.0 421101.0 469061.0 True False 462710.1517612131 466723.29205176135 462521.603341455 478196.1335919093 502476.5657271357 530103.0772448851 428808.372912148 489105.0855192362 505332.966545012 455517.9901631618 1.0157889737691261 1.0245990325971228 1.015375052861874 1.0497853957878247 1.1030883007434102 1.1637368637295922 0.9413642977274143 1.0737338504326555 1.109358965963138 1.0 18.797148507183465 -5.91314556523317 4.439333230303971 1.0683198335908337 1.0195719698258567 0.1144764809304385 0.057361075664023146 0.47461085692322014 17.08541813030728 0.01682457851161225 0.025532622692408562 1.221390210454267e-06 5.91314556523317 -0.04874786376497697 QYT(ph)SPEEIDAQLQAEK ddPTM_A459_Selumetinib_30min_R1 1 QYTSPEEIDAQLQAEK 16 0 Q13442;F8WBW6 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 QYT(0.905)S(0.095)PEEIDAQLQAEK 156.0 0.00087719 0.0 481.11 728.59 858.69 666.54 683.04 526.99 712.06 512.16 440.71 558.33 True False 492.31892692290296 643.2863440876986 742.0846144465411 550.1413015054053 621.2591526005062 521.6889590686359 658.3487409172054 498.5758530698598 747.8526818151371 629.9970940947474 0.7814622186953476 1.0210941449056155 1.177917519624204 0.873244189000446 0.986130187621267 0.8280815323731912 1.0450028215815772 0.7913938933103671 1.1870732243451667 1.0 9.299201363871777 -8.277625553956492 24.9970845676437 1.0935365865891076 0.9481483231750487 0.19253283612481653 0.12602360323154704 1624.4133400041346 2508634.5713242134 0.11619602963687425 0.030358452789538613 5.276846318035411e-09 8.277625553956492 -0.14538826341405886 QYTS(ph)PEEIDAQLQAEK ddPTM_A459_Selumetinib_30min_R2 1 QYTSPEEIDAQLQAEK 16 0 Q13442;F8WBW6 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 QY(0.005)T(0.103)S(0.892)PEEIDAQLQAEK 109.1 0.0030287 2356200.0 33089.0 30540.0 34033.0 37606.0 39484.0 28650.0 32954.0 29628.0 31816.0 35787.0 True False 31250.045845761957 32882.31979842249 31843.353832328678 32483.997926031574 34523.66692856142 32596.277441194386 34486.426297112186 29714.212574820558 38180.08901331541 34753.7363242074 0.899185214338955 0.9461520767629985 0.9162569899038014 0.934690809154961 0.9933800097491754 0.9379215269723314 0.992308452115722 0.854993324965851 1.0985894770318958 1.0 15.084880467792471 -3.756325675241022 0.13194883415882155 1.0300127340246639 0.7681985780410269 0.2148786192902975 0.05663429334144733 77.04382869653581 1.235652474629873 0.3451202331239854 3.5559313100198704 0.00017525657687189998 3.756325675241022 -0.261814155983637 RAADEDWDS(ph)ELEDDLLGEDLLSGK ddPTM_A459_Selumetinib_30min_R1 2 RAADEDWDSELEDDLLGEDLLSGK 24 1 Q96EV2;A8MTF7;Q96EV2-2 Q96EV2 RBM33 RNA-binding protein 33 1 RAADEDWDS(1)ELEDDLLGEDLLSGK;RAADEDWDS(1)ELEDDLLGEDLLSGK 70.679 0.00072075 11882900.0 2597.0299999999997 2900.7999999999997 3084.5200000000004 3328.55 2866.8900000000003 2553.34 3206.47 2905.79 1360.2 2408.0 True False 2657.5357460592923 2561.1729874546654 2665.6591260555565 2747.2812271218804 2607.58030569054 2527.6557178472285 2964.6033863561915 2828.7190098638494 2308.1600549226246 2717.090255906276 0.9780815121185146 0.9426160878856764 0.9810712471774093 1.0111115084049846 0.95969587319461 0.9302803660470004 1.091094924032017 1.041083932973857 0.8494970124401502 1.0 11.40784677425057 RAAEDDEDDDVDTK ddPTM_A459_Selumetinib_30min_R1 2 RAAEDDEDDDVDTK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ; 294.26 7.069199999999998e-67 69323900.0 13041.8 13772.1 16444.8 17284.4 12822.7 13158.1 12165.199999999999 12306.3 7657.3 9903.0 False True 13345.64856507475 12159.656129524416 14211.686484820455 14266.004008371649 11662.889049031557 13025.741460598902 11247.569169741293 11979.896947503936 12993.878832935598 11174.146513388645 1.1943326990642422 1.0881955158682546 1.2718364188076725 1.2766974185704831 1.04373869047245 1.1657034785602383 1.006570761915881 1.0721084543817154 1.162852018931968 1.0 13.44787702143456 -6.27209782487733 24.926818768265722 1.079865143012415 1.2038012938467837 0.4527735307654738 0.0712515382328994 699.410136034786 1635702.5629384504 0.022433408863435908 0.025710415044308717 5.344439622795228e-07 6.27209782487733 0.1239361508343686 RAAEDDEDDDVDTK ddPTM_A459_Selumetinib_30min_R2 4 RAAEDDEDDDVDTK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ;;; 246.63 3.8521000000000005e-27 139182500.0 441792.0 466650.0 456595.0 469389.0 445004.0 338610.0 328109.0 342220.0 255193.0 392380.0 False True 417238.9692735007 502440.5544837552 427218.17480304727 405457.40845881175 389098.6191337644 385250.4539044621 343366.71863564936 343215.8035424291 306238.73068817536 381050.96987432597 1.09496892085358 1.318565216221506 1.1211575578562303 1.0640503253214006 1.0211196136361826 1.011020793442728 0.901104434267402 0.9007083846437257 0.8036686818804729 1.0 18.5396244618318 -6.307990914238588 0.7980249629639895 0.8893185173446835 1.215245039736631 0.7021517171343347 0.07371737960473683 0.34828624922403606 0.4818942080610806 0.0404040326393867 0.0653549121658164 4.92049829619727e-07 6.307990914238588 0.3259265223919475 RAAEDDEDDDVDTKK ddPTM_A459_Selumetinib_30min_R1 5 RAAEDDEDDDVDTKK 15 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ;;;; 122.52 0.00098246 92351100.0 19988.9 23538.0 29236.8 32048.100000000002 20706.7 23519.0 21160.899999999998 20431.0 14068.800000000001 17430.600000000002 False True 20454.602478371282 20782.160017480684 25266.603146246754 26451.50095234403 18833.78264106481 23282.420213543435 19564.71627626168 19889.103510758952 23873.726055503157 19667.98729842191 1.039994696356779 1.0566490460947253 1.284656267206053 1.344901262696382 0.9575856621880148 1.1837723840411232 0.9947492836662286 1.0112424422988509 1.2138367639386618 1.0 14.263561708129053 -6.280793487578912 24.994312001558747 1.0636661973552013 1.1799935411122162 0.20988411914644645 0.11521430482114278 1454.0998191497613 1877851.1136835883 0.037259415744639715 0.042308578816665006 5.238494743032476e-07 6.280793487578912 0.11632734375701492 RAAEDDEDDDVDTKK ddPTM_A459_Selumetinib_30min_R2 4 RAAEDDEDDDVDTKK 15 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 ;;; 111.31 0.0020836 185838000.0 491178.0 479236.0 487102.0 482160.0 432687.0 290188.0 319821.0 335411.0 208489.0 472769.0 False True 463880.29310132284 515991.8602133859 455762.3876365587 416488.9762276071 378328.9907891417 330158.7629356129 334693.31021328876 336386.9904797201 250192.62566938408 459118.9305686195 1.0103706517324529 1.1238740680423025 0.992689164596407 0.9071483410884079 0.8240326538498002 0.7191138089791043 0.7289904378344203 0.7326794172113624 0.5449407746256948 1.0 18.808508393471215 -6.0702807252103455 1.2557674129507022 0.7253385830546715 1.071337698842382 0.5871633772159138 0.10855094849931275 0.28873826061316926 0.9262968676040533 0.03910198674719563 0.0684739779702996 8.505880457247681e-07 6.0702807252103455 0.3459991157877105 RAAEEAEEAR ddPTM_A459_Selumetinib_30min_R1 2 RAAEEAEEAR 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 184.36 0.00023812 5791000.0 1996.79 2571.71 2606.99 2669.41 2740.63 2314.55 1994.5 2431.8 2210.31 1910.1100000000001 False True 2043.311321923017 2270.612997644457 2252.975077171027 2203.247654531679 2492.740500397525 2291.2677284432566 1844.0532592188374 2367.3007644003533 3750.734635344818 2155.291224546984 0.9480441894122668 1.0535063530088435 1.0453228090531361 1.0222505568799758 1.1565678326934536 1.0630896197913362 0.8555935449542023 1.0983670036971136 1.740244934246961 1.0 11.073667105170461 -8.0241457843177 24.85064484757383 1.3865170896376064 1.025993645099588 0.3650531557025539 0.18143909903733602 661.8006853783311 681115.311626392 0.11059270151595416 0.0423193522633169 9.459195810273654e-09 8.0241457843177 -0.36052344453801854 RAAEEAEEAR ddPTM_A459_Selumetinib_30min_R2 1 RAAEEAEEAR 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 155.97 0.0006989 3661600.0 17800.0 13522.0 18588.0 22907.0 18406.0 12073.0 18666.0 23285.0 13963.0 24420.0 False True 16810.747259045685 14559.093919917132 17392.068317084177 19787.027083220913 16093.673728272259 13735.946162217802 19534.00598597731 23352.75549496074 16755.990158817047 23714.931149220225 0.7088676392635634 0.6139209862473437 0.7333805106853978 0.8343699991670241 0.6786304217797166 0.5792108809335277 0.8237007252125044 0.9847279483132131 0.7065586677601635 1.0 14.533508059443898 -8.294452401800077 0.46300851163315476 0.9991544843313549 0.6814851226866762 0.41495521077549136 0.10378571234414008 1.0248527744228166 0.582682804068785 0.12884334415587895 0.07313779191659052 5.076303717133919e-09 8.294452401800077 -0.31766936164467874 RAAEEEDEADPKR ddPTM_A459_Selumetinib_30min_R1 2 RAAEEEDEADPKR 13 2 P20962 P20962 PTMS Parathymosin 0 ; 94.191 0.010217 3947700.0 1049.49 1028.69 1963.3400000000001 2150.19 1677.5099999999998 1453.46 1080.27 1422.9499999999998 965.19 1050.06 False True 1073.9410750479453 908.250496574993 1696.7292118546534 1774.699680565169 1525.7795166884446 1438.8395120360915 998.7843641696338 1385.2087436069926 1637.8569353115467 1184.8454294505584 0.9063976180808309 0.7665561042811895 1.4320257897618494 1.4978322373983755 1.2877456238287432 1.2143689600957623 0.8429659593933653 1.1691050234707387 1.382338062502432 1.0 10.210483147405645 -5.249533449805487 24.97174168593321 1.2318272432958226 0.8364768138669272 0.40846059630826403 0.18857152617085632 779.3497099262083 1634617.0158917974 0.052183641015703164 0.13573843628626397 5.62945757066065e-06 5.249533449805487 -0.3953504294288954 RAAS(ph)AATAAPTATPAAQESGTIPK ddPTM_A459_Selumetinib_30min_R1 1 RAASAATAAPTATPAAQESGTIPK 24 1 B8ZZ81;O00116 B8ZZ81 AGPS Alkyldihydroxyacetonephosphate synthase, peroxisomal 1 RAAS(0.874)AAT(0.111)AAPT(0.015)AT(0.001)PAAQESGTIPK 92.788 1.5088e-05 10072000.0 3078.2 3060.2 3733.9 4218.8 3366.6 3080.0 2847.9 3040.0 1770.4 2323.8 True False 3149.9160708654545 2701.9103613516163 3226.8568888445675 3482.0657766840754 3062.091624421507 3049.017996416248 2633.080610142556 2959.3693246883267 3004.239495099994 2622.0823657288242 1.2013032512004693 1.0304445034473977 1.2306466535987868 1.3279772680658006 1.1678090911421004 1.1628231196195677 1.004194469463462 1.1286332433213826 1.145745661679452 1.0 11.35649728935301 -7.066022033429357 6.787235017116196 1.0801472790185678 1.18994242752338 0.33580518587846964 0.08101274408359994 0.35235889575070334 30.354126904438672 0.03286630642004134 0.0255649592831336 8.589699415511947e-08 7.066022033429357 0.10979514850481231 RAAVAASSSS(ph) ddPTM_A459_Selumetinib_30min_R2 2 RAAVAASSSS 10 1 P61927 P61927 RPL37 60S ribosomal protein L37 1 RAAVAASS(0.011)S(0.113)S(0.876);RAAVAASSS(0.016)S(0.984) 112.3 0.01495 5734000.0 17674.8 17593.699999999997 23956.0 22450.0 23510.0 14656.5 19461.6 41248.0 13481.599999999999 25035.0 True False 16692.505373830383 18943.080217338116 22414.697041320658 19392.271271589878 20556.463617933317 16675.299836539823 20366.6029624288 41368.02485102602 16178.296707377205 24312.174501258316 0.686590390051965 0.7791602604842148 0.9219536097094297 0.7976362324392744 0.8455213916332076 0.685882697809559 0.8377121084489868 1.701535370638482 0.6654401360330756 1.0 14.56939131454025 -7.557179594242197 24.999985538611604 1.164017627119426 0.792420337739662 0.2695466146733124 0.24632468278927921 204.1249033613919 148773.11998830189 0.10625554503053342 0.06134696599748016 2.7721734878438202e-08 7.557179594242197 -0.371597289379764 RADDDRFPR ddPTM_A459_Selumetinib_30min_R2 1 RADDDRFPR 9 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 117.81 0.0052577 0.0 9680.9 10986.0 10814.0 9584.7 11104.0 8439.3 7672.9 8393.0 8045.7 9860.1 False True 9142.87433371323 11828.590874442354 10118.239013392953 8279.247325470265 9709.016248980495 9601.736970662192 8029.705053562911 8417.422240464048 9655.064815640937 9575.413293383552 0.9548281680991044 1.2353086506057873 1.0566895342663156 0.8646360289420704 1.0139527090375577 1.0027490904540726 0.8385752977483804 0.8790662066023138 1.008318337790435 1.0 13.225119042555756 -5.583070378124335 6.720036562923096 0.9405658069577335 1.107492060167166 0.34598171324222526 0.08776470535634309 0.19168020677488024 16.73243021815845 0.023309572514005995 0.040833746410808586 2.6117380837168894e-06 5.583070378124335 0.16692625320943255 RADLNQGIGEPQS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 3 RADLNQGIGEPQSPSR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.551)PS(0.449)R;RADLNQGIGEPQS(0.918)PS(0.082)R;RADLNQGIGEPQS(0.874)PS(0.126)R 294.93 6.9042e-75 334220000.0 9805.1 9508.6 9298.099999999999 10393.4 9109.2 7804.299999999999 8135.2 7517.700000000001 4942.299999999999 7185.599999999999 True False 10033.539752596613 8395.328691571793 8035.4690908073735 8578.387798281094 8285.274468359885 7725.795827737441 7521.555314312903 7318.306175068896 8386.722128689957 8107.941753671156 1.237495292569606 1.0354451162368687 0.9910615215222818 1.058022869293175 1.0218714835498708 0.9528677021192604 0.927677521968785 0.9026096138092352 1.0343836183693071 1.0 12.98512000938308 -1.5228787453300585 0.8499354709274379 0.9733857414314782 91.07153129176619 0.7294953313989248 0.04566776147625353 364.28410464296167 1.015261862798256 0.016967222950141136 63459.963920800874 0.0299999999965654 1.5228787453300585 90.09814555033472 RADLNQGIGEPQS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 RADLNQGIGEPQSPSR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.82)PS(0.18)R;RADLNQGIGEPQS(1)PSR 249.49 4.1801e-29 234580000.0 177977.0 168973.0 183574.0 190876.0 247341.0 190856.0 165512.0 175796.0 134331.0 190072.0 True False 168085.75083838066 181932.68576617085 171763.04870025904 164878.35952053414 216267.81232340442 217144.68158173116 173208.63595580615 176307.53725540533 161200.9535217395 184584.12749363625 0.9106186600154751 0.9856355919467842 0.9305407297611804 0.8932423484040821 1.1716490212890083 1.1763995340781264 0.9383723200239832 0.9551608778576248 0.8733196928175586 1.0 17.49391897449121 RADLNQGIGEPQS(ph)PSRR ddPTM_A459_Selumetinib_30min_R1 1 RADLNQGIGEPQSPSRR 17 2 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.861)PS(0.139)RR 98.421 0.0058736000000000005 109450000.0 3175.7 3522.1 4133.1 4095.0 3166.6 3317.4 3056.3 3293.0 1898.4 2568.7 True False 3249.687631163481 3109.730894620132 3571.847721493204 3379.8851226702595 2880.1815891086376 3284.0299679582004 2825.7608303587535 3205.6589428285088 3221.4461463498815 2898.4176662568316 1.1211937013067885 1.0729064105644242 1.2323440348423198 1.166113897944605 0.9937082645608681 1.1330423514149253 0.9749322408761361 1.1060031065048208 1.1114499417574368 1.0 11.501049789018674 -6.240964155294383 24.849143035884772 1.058569267343266 1.1487803346118628 0.3548124856653584 0.06247100087625716 918.4117633140694 1114603.132293953 0.018362180772910196 0.02367439651794869 5.741638491434023e-07 6.240964155294383 0.09021106726859673 RADLNQGIGEPQS(ph)PSRR ddPTM_A459_Selumetinib_30min_R2 1 RADLNQGIGEPQSPSRR 17 2 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.864)PS(0.136)RR 117.13 0.0018031 61452000.0 100470.0 104760.0 117890.0 126480.0 107400.0 81933.0 74315.0 67343.0 56690.0 98948.0 True False 94886.27961327633 112794.7551435081 110305.08574892668 109253.20580983024 93907.45183181777 93218.52703627858 77770.79475237886 67538.95698076626 68029.58405094457 96091.11414222146 0.98746154064608 1.1738312761840195 1.1479218108103895 1.136975117679747 0.9772750859442454 0.9701055905992385 0.8093442920983592 0.7028637099659805 0.7079695626200786 1.0 16.552115406014998 -6.9090824313817985 1.440113613761784 0.7754275493962455 1.1146462713968595 0.6598201577001477 0.09538043840554693 0.22237843913473607 0.9503898611049318 0.04597766985072353 0.036651174989143755 1.2328708056424976e-07 6.9090824313817985 0.339218722000614 RADLNQGIGEPQSPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 RADLNQGIGEPQSPSR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.333)PS(0.667)R 160.05 2.9266e-05 111890000.0 3411.9 3718.1 3711.0 3871.1 3426.0 3793.0 3434.4 3123.4 1820.6 3174.8 True False 3491.390631598287 3282.783123502206 3207.0665830638713 3195.085054546725 3116.1189049094287 3754.845863768453 3175.3404429486964 3040.5572857669504 3089.4252286370606 3582.3165051707847 0.9746181350974283 0.9163855619021305 0.8952493668369977 0.8919047353674299 0.8698614152076073 1.0481613945469743 0.8863930471708317 0.8487684662642598 0.8624099026922174 1.0 11.806677092747554 -10.652991413950867 4.735736649214342 1.000004564735697 0.9099405900972699 0.18394766468050505 0.0565975789157758 4.221967084299847e-06 7.754493074967882e-07 0.05661729098193113 0.01373066740202731 2.2233538461642104e-11 10.652991413950867 -0.09006397463842708 RADLNQGIGEPQSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 RADLNQGIGEPQSPSR 16 1 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.094)PS(0.906)R;RADLNQGIGEPQS(0.249)PS(0.751)R 152.09 9.3449e-05 260194000.0 189094.0 206759.0 248495.0 291053.0 233172.0 179277.0 211107.0 182737.0 167709.0 220155.0 True False 178584.91248325782 222616.75046503064 232507.1022408994 251411.0793055706 203878.84877587168 203970.77943542795 220923.89380058437 183268.73441626108 201255.4861809814 213798.5531186145 0.8352952341271443 1.0412453555825696 1.0875054992159159 1.175925073571891 0.9536025656018382 0.9540325528876047 1.0333273568882235 0.8572028750568035 0.9413323113993467 1.0 17.70589256409174 -6.437237135982711 24.9999999999918 0.9530888968207254 1.0423872217395063 0.15194235635920694 0.08984905520028347 146.61654459988685 42796.804221844366 0.028886598506746672 0.03275431545034729 3.653952219223644e-07 6.437237135982711 0.08929832491878087 RADLNQGIGEPQSPS(ph)RR ddPTM_A459_Selumetinib_30min_R2 2 RADLNQGIGEPQSPSRR 17 2 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 1 RADLNQGIGEPQS(0.275)PS(0.725)RR;RADLNQGIGEPQS(0.2)PS(0.8)RR 64.843 0.017535 29435200.0 51749.0 63482.0 74507.0 89826.0 118370.0 80192.0 46674.0 46029.5 78514.0 104339.0 True False 48872.99774766041 68350.86527319766 69713.30073708795 77591.54384150713 103499.30235877352 91237.72008950298 48844.43348277646 46163.438224406054 94218.99386445347 101326.46196472106 0.4823320266000857 0.6745608595017899 0.6880068580837264 0.7657579504603866 1.0214439579940033 0.9004332957097556 0.482050123291413 0.45559113906966203 0.9298557557181637 1.0 16.62865146555349 -4.657023306552736 1.375921015206084 0.7663762562719517 0.304842831062104 0.1962788950643508 0.18591686372253813 3.340296153515763 4.61380336325397 0.05819157605053319 2.330680751048297 2.2028082454700213e-05 4.657023306552736 -0.4615334252098477 RADNCS(ph)PVAEEETTGSAESTLPK ddPTM_A459_Selumetinib_30min_R1 2 RADNCSPVAEEETTGSAESTLPK 23 1 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 RADNCS(1)PVAEEETTGSAESTLPK;RADNCS(1)PVAEEETTGSAESTLPK 131.2 3.8655000000000005e-06 54517000.0 8096.200000000001 10412.5 11169.2 12288.9 11496.4 9611.0 10093.900000000001 8954.2 5270.9 9155.0 True False 8284.82570753717 9193.399659360075 9652.483988023978 10142.874306222842 10456.552649854268 9514.322066089799 9332.50899635449 8716.70552865929 8944.332328695531 10330.133427251641 0.8020056822965324 0.8899594302535551 0.9344007079869874 0.9818725360763689 1.012237908008925 0.9210260577070889 0.9034257942627009 0.8438134502371468 0.8658486738515626 1.0 13.334571268175567 -4.816543169351514 2.533616201547094 0.9300510444746077 0.7802111228323109 0.37171808421622143 0.051719429203085726 0.5812292691788953 5.108300608658626 0.015120951041212109 0.18462506850191443 1.5256567353042996e-05 4.816543169351514 -0.14983992164229687 RADNCS(ph)PVAEEETTGSAESTLPK ddPTM_A459_Selumetinib_30min_R2 3 RADNCSPVAEEETTGSAESTLPK 23 1 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 RADNCS(1)PVAEEETTGSAESTLPK;RADNCS(1)PVAEEETTGSAESTLPK;RADNCS(0.84)PVAEEET(0.139)T(0.019)GS(0.002)AESTLPK 160.91 5.0813e-10 62173600.0 316122.0 307328.0 333515.0 336606.0 384138.0 271055.0 273531.0 311193.0 236274.0 350296.0 True False 298553.2047766318 330899.069384728 312057.008003676 290759.68212226225 335879.1502027084 308390.36585769465 286250.7334913937 312098.52010922524 283535.40204714896 340182.0443016888 0.877627757777425 0.9727117433960499 0.9173235719840926 0.8547178988212659 0.9873512015961536 0.9065451014345723 0.8414633819930061 0.9174456010748239 0.8334813867944687 1.0 18.375947468228958 -7.000942344849049 24.999933329687106 0.8887589395607668 0.9233922985258849 0.028225082559286463 0.05644512415856176 96.45146989651664 2558868.0927058244 0.018975332408169468 0.0165374545252966 9.978325231757756e-08 7.000942344849049 0.0346333589651181 RADVQHLEDDR ddPTM_A459_Selumetinib_30min_R1 1 RADVQHLEDDR 11 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 0 74.69800000000002 0.036898 2263300.0 796.26 931.28 793.74 759.36 605.49 615.12 728.58 639.47 553.33 793.73 False True 814.811308747751 822.2453046596742 685.9544677017285 626.7520309525985 550.7235364079419 608.9324512842735 673.622624016877 622.5091783086991 938.9605963757791 895.612977084921 0.9097805967481996 0.9180810525277927 0.7659050117098595 0.6998023108068147 0.6149124125026193 0.6799057928640702 0.752135845786215 0.6950649379097524 1.0483999455121205 1.0 9.806731622208673 -8.265532041837101 24.984817456148406 1.0242000160181002 0.7512502081253847 0.5812048184916014 0.09156033126227502 288.62366180109785 1761947.9113424122 0.08901262368089363 0.026249396740415508 5.425852184267723e-09 8.265532041837101 -0.2729498078927155 RAEDGS(ph)VIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R1 2 RAEDGSVIDYELIDQDAR 18 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 1 RAEDGS(1)VIDYELIDQDAR;RAEDGS(1)VIDYELIDQDAR 169.33 5.1281e-08 36545000.0 5816.7 7045.9 8008.9 7940.700000000001 7945.2 6435.8 6243.7 5763.8 3339.3 4764.0 True False 5952.217792672047 6220.96275244996 6921.335369738679 6554.005810399941 7226.558062838993 6371.061695238864 5772.732682168288 5610.925300539007 5666.548207177707 5375.505805289658 1.1072851575780807 1.1572795152278224 1.2875691368294828 1.2192351841478068 1.3443494109387517 1.185202272308877 1.0738957209362041 1.0437948546195763 1.054142328634759 1.0 12.392184795354982 -7.262252971924479 3.1917327437115675 1.0410352074343288 1.225867920341492 0.6550210130726869 0.06251698082995844 0.17144511227886142 3.6216666508414863 0.029365982553258493 0.020182830708849686 5.466974246852328e-08 7.262252971924479 0.1848327129071632 RAEDGS(ph)VIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R2 2 RAEDGSVIDYELIDQDAR 18 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 1 RAEDGS(1)VIDYELIDQDAR;RAEDGS(0.999)VIDY(0.001)ELIDQDAR 166.43 7.5149e-08 19773600.0 51613.0 48646.0 56815.0 63850.0 54212.0 42200.0 44592.0 40806.0 39746.0 54824.0 True False 48744.556083209296 52376.9917784565 53159.58475549483 55153.51985260641 47401.403898570876 48012.66694654111 46665.61635737171 40924.738704203046 47696.31059602828 53241.08867014125 0.9155439398546013 0.9837701122710257 0.9984691538681452 1.0359202118182398 0.8903162028156385 0.9017972424269312 0.8764962836596314 0.7686683297885777 0.8958552837176936 1.0 15.700252451230432 -6.382084420266226 5.919197472567848 0.875820203762288 0.9841777682898122 0.3662542261602548 0.059692289316275175 0.2299915345269152 10.240441493526127 0.018717985493239286 0.021231288006827227 4.14873389695565e-07 6.382084420266226 0.10835756452752421 RAEDGSVIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R1 7 RAEDGSVIDYELIDQDAR 18 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 ;;;;;; 276.62 6.8822e-56 636032200.0 12787.050000000001 17513.6 16695.47 17474.6 17149.1 14408.099999999997 13206.65 13870.890000000001 7576.239999999999 10889.94 False True 13084.963385731953 15463.099570148253 14428.31687565222 14422.989148867817 15597.966932919519 14263.16759550809 12210.461757765079 13502.988938199369 12856.325933323753 12287.769875998341 1.064876988890455 1.2584138314920978 1.1742014231431044 1.173767843507567 1.2693895711203849 1.160761288618229 0.9937085314085945 1.09889663254312 1.0462700769189999 1.0 13.584935482340233 -7.13275703450276 5.329609562265495 1.0437717059469835 1.1925357185711467 0.6038467134698662 0.05906814628213778 0.15735607236156318 6.1664146750962905 0.021954706731369813 0.01693252689419519 7.366190828535579e-08 7.13275703450276 0.14876401262416317 RAEDGSVIDYELIDQDAR ddPTM_A459_Selumetinib_30min_R2 7 RAEDGSVIDYELIDQDAR 18 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 ;;;;;; 266.29 7.496500000000002e-44 449571100.0 322440.0 293115.0 339806.0 332925.0 324523.0 197928.0 268031.0 245847.0 215230.0 300856.0 False True 304520.07562958926 315595.97798672674 317943.25191279966 287580.0406723414 283753.51946757035 225190.7853885068 280494.97259335074 246562.37406783798 258282.0140286605 292169.5055622364 1.0422719340390643 1.0801811002808441 1.0882150459233093 0.9842917730888333 0.9711948511585056 0.7707538983411732 0.9600419183158085 0.8439018082786075 0.8840142763415212 1.0 18.156446082865884 -6.190349568698634 1.9744713081062835 0.8875280067030689 1.0691672548468933 0.5827730220352614 0.06294814922368235 0.2127754099778542 1.6313372803025792 0.020156592281196192 0.027716531833462368 6.451347435060763e-07 6.190349568698634 0.18163924814382448 RAEDGSVIDYELIDQDARDLY(ph)DAGVK ddPTM_A459_Selumetinib_30min_R1 1 RAEDGSVIDYELIDQDARDLYDAGVK 26 2 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2 Annexin A2;Annexin 1 RAEDGSVIDYELIDQDARDLY(1)DAGVK 103.25 6.463e-05 0.0 447.7 468.68 527.11 550.17 717.99 416.44 480.09 399.31 278.3 311.76 True False 458.1305389274461 413.80672771657925 455.5313572079755 454.09313746996247 653.0479312714298 412.250991697267 443.8764247773235 388.71900165832136 472.25477377221443 351.7774327995603 1.302330667665327 1.1763310807727756 1.294941956858083 1.2908535202390334 1.8564236087410724 1.1719085798552746 1.261810404507217 1.1050140384639455 1.3424817220759613 1.0 8.458519123885182 RAELGS(ph)WSSQEHLEWEPACQTPQPSAR ddPTM_A459_Selumetinib_30min_R1 1 RAELGSWSSQEHLEWEPACQTPQPSAR 27 1 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6;H3BTL6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 RAELGS(0.438)WS(0.124)S(0.438)QEHLEWEPACQTPQPSAR 63.109 0.0015773 19625000.0 1349.1 1566.1 1359.8 1719.9 1168.4 1231.2 1252.9 1412.6 695.87 1166.6 True False 1380.5314051083706 1382.7402839398617 1175.1466288467395 1419.5517515215097 1062.718426297774 1218.8152458401573 1158.3927442844238 1375.1332592285312 1180.8405656660825 1316.344473646288 1.0487615003117567 1.050439540426418 0.8927348823758655 1.0784044601861218 0.8073254741245904 0.9259090384327944 0.8800072986029741 1.0446606391861832 0.8970604498343369 1.0 10.362321361417271 -5.2447064040638285 23.3080294997333 0.9398076324123859 1.0496005934097006 0.2424668828574339 0.07693614560108884 465.9052160736963 648970.4186795979 0.018854795261653783 0.04950760870271239 5.692376222946823e-06 5.2447064040638285 0.10979296099731473 RAELGSWS(ph)SQEHLEWEPACQTPQPSAR ddPTM_A459_Selumetinib_30min_R2 1 RAELGSWSSQEHLEWEPACQTPQPSAR 27 1 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6;H3BTL6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 RAELGS(0.056)WS(0.472)S(0.472)QEHLEWEPACQTPQPSAR 85.274 3.2276e-05 5835700.0 9161.6 8970.8 10244.0 10795.0 12908.0 8764.3 5396.0 7416.6 6854.7 11513.0 True False 8652.434948790622 9658.831514331647 9584.912192823878 9324.702377586318 11286.381641015876 9971.502770605934 5646.924691971158 7438.1810781157765 8225.831536320511 11180.5897756336 0.7738800119155871 0.8638928453829515 0.8572814480424584 0.8340080948062412 1.0094621006141227 0.8918583876798084 0.505065010459267 0.665276271411564 0.7357242955329122 1.0 13.448708671839663 -7.160159549018924 24.98422707581188 0.698526013193223 0.8752646191920938 0.22687848536616606 0.12709112281450866 46.35620768846631 11424.666923944807 0.04711820187458194 0.036497602515258805 6.915768560633703e-08 7.160159549018924 0.1767386059988707 RAELGSWSS(ph)QEHLEWEPACQTPQPSAR ddPTM_A459_Selumetinib_30min_R1 1 RAELGSWSSQEHLEWEPACQTPQPSAR 27 1 B7Z896;F5H3M2;Q9BVG8-5;Q9BVG8-2;Q9BVG8;Q9BVG8-6;H3BTL6 B7Z896 KIFC3 Kinesin-like protein;Kinesin-like protein KIFC3 1 RAELGS(0.225)WS(0.225)S(0.549)QEHLEWEPACQTPQPSAR 66.587 0.00077701 25734000.0 860.12 745.03 997.27 1158.8 863.62 1090.4 763.81 964.45 449.71 703.82 True False 880.1591224978223 657.8015412449498 861.8462116119928 956.4373333700368 785.5057234844952 1079.4315660039858 706.1951967530406 938.869653024888 763.1250244811446 794.162152787357 1.1082864115453406 0.8282962603244092 1.0852270012957401 1.2043350718907027 0.9890999221349452 1.3592080184322408 0.8892330039582355 1.1822140475086045 0.9609183990986249 1.0 9.6332897980722 -4.448219384980217 22.92378230806699 1.0629851560052486 3.439606522121942 0.00870900942194075 0.15084776426015378 5838.852072675465 1694839.3515114535 0.03488209788084956 39258.19209554572 3.5627111668652965e-05 4.448219384980217 2.3766213661166935 RAELPGSS(ph)SPLLAQPR ddPTM_A459_Selumetinib_30min_R1 1 RAELPGSSSPLLAQPR 16 1 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 RAELPGS(0.243)S(0.514)S(0.243)PLLAQPR 133.9 0.00089253 12271000.0 2148.0 2444.5 2779.8 2731.9 2716.0 2466.9 2587.3 2146.4 1402.3 1809.8 True False 2198.0442207195756 2158.2968035827803 2402.31842834841 2254.824949114259 2470.3382795487473 2442.0852257659876 2392.13787795282 2089.4704995102056 2379.6006800602827 2042.1054589448431 1.0763617574654083 1.056897817950094 1.1763929320230548 1.104166750662979 1.2097016188503664 1.1958663618811411 1.1714076114310172 1.0231942186716625 1.1652682625361688 1.0 10.995841656836722 -11.336816240839527 7.496800509242127 0.9946975156539135 1.131629391349588 0.29973942755606475 0.06007580114844664 0.005732970752722658 0.00014228598416466166 0.06263370473457223 0.01472442717003305 4.6045135905672865e-12 11.336816240839527 0.13693187569567455 RAELPGSSS(ph)PLLAQPR ddPTM_A459_Selumetinib_30min_R1 1 RAELPGSSSPLLAQPR 16 1 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 RAELPGSS(0.004)S(0.996)PLLAQPR 210.47 2.3515e-08 33557000.0 2122.1 2045.7 2670.1 2509.8 2200.6 1833.7 2094.2 1783.7 1155.1 1711.4 True False 2171.5408011122013 1806.1884929798707 2307.5150858094416 2071.5105447809083 2001.5561185474858 1815.2546428663884 1936.2328079499073 1736.3904817258465 1960.1203348339366 1931.0748604476748 1.124524401197362 0.9353280548435848 1.194938183429356 1.0727241015921447 1.036498459766325 0.9400229271513398 1.002671024105734 0.899183411938419 1.0150410918712536 1.0 10.915188377849253 -6.560814888732466 3.6160419814569544 0.9672361746525746 1.0780715138413235 0.36826733690416324 0.0681061128064867 0.25149216921945894 6.947673901087797 0.022468513758098732 0.02321347470044044 2.7490656498905337e-07 6.560814888732466 0.11083533918874888 RAELPGSSS(ph)PLLAQPR ddPTM_A459_Selumetinib_30min_R2 3 RAELPGSSSPLLAQPR 16 1 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 RAELPGSS(0.008)S(0.991)PLLAQPR;RAELPGSS(0.004)S(0.996)PLLAQPR;RAELPGSS(0.12)S(0.88)PLLAQPR 216.35 7.2648e-11 64010000.0 137259.0 114184.0 161578.0 156063.0 139911.0 121378.0 128513.0 156555.0 119071.0 146624.0 True False 129630.6942713118 122941.54564057228 151182.24739282476 134806.9501763089 122334.12935979008 138096.71774021964 134489.10914367836 157010.5491309247 142888.52712171458 142390.58414509727 0.9103881064159198 0.863410641782983 1.0617432908258084 0.946740621830299 0.859144795944727 0.9698444498232963 0.9445084445094541 1.1026750825808085 1.0034970217982244 1.0 17.11949422287381 -7.665858069053531 8.313830834033762 1.0394919491325365 0.936737550958655 0.3642789066044134 0.059821084178623085 0.26721621704202125 20.47182321762 0.028755869667497228 0.016519717651399767 2.158449692703454e-08 7.665858069053531 -0.10275439817388154 RAETFAGYDCT(ph)NSPTK ddPTM_A459_Selumetinib_30min_R1 1 RAETFAGYDCTNSPTK 16 1 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 RAETFAGYDCT(0.588)NS(0.384)PT(0.028)K 187.56 0.00011096 6367900.0 1776.5 1957.9 2285.8 2163.8 2105.7 1544.0 2196.5 2029.5 1173.6 2059.9 True False 1817.8889935327406 1728.6681577969846 1975.4009150006448 1785.9329495565119 1915.2398067915296 1528.4687618398327 2030.816236587705 1975.6710672549232 1991.513483647398 2324.308230125141 0.7821204476976211 0.7437344735056558 0.849887673845344 0.7683718219508077 0.8240042271366104 0.6576015788394552 0.8737293144973141 0.8500039029455886 0.8568198734727084 1.0 11.182585684121698 -8.59642247694651 0.757891715088405 0.9984022102852187 0.7781712482685638 0.5857136445841813 0.05564440471053017 0.5507179247318778 0.7003216030612909 0.05377407084585229 0.02009279423895118 2.5326636840813845e-09 8.59642247694651 -0.22023096201665493 RAETFAGYDCTNS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 RAETFAGYDCTNSPTK 16 1 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 RAETFAGYDCT(0.003)NS(0.997)PTK;RAETFAGYDCTNS(0.997)PT(0.003)K 197.51 1.8914e-06 24764000.0 6240.700000000001 7801.9 6991.4 7695.5 6711.9 6393.9 7240.200000000001 6773.200000000001 4072.3 6450.0 True False 6386.096167711665 6888.449920995089 6042.006281011244 6351.625387425887 6104.809830082191 6329.583171196701 6694.065884881539 6593.552733545718 6910.395670975887 7277.920328320387 0.8774616758116478 0.9464860303829157 0.8301830754453492 0.8727253254903009 0.8388124017140858 0.869696683346004 0.9197772966589219 0.9059665998112666 0.9495014178824738 1.0 12.829310542688848 -8.310971800267897 0.9505350708365666 0.9986392635400458 0.873891909487181 0.6294823424195232 0.030927388617864936 0.3610116450831534 0.6946485196009464 0.030439968013768703 0.010682994754081111 4.886840896861561e-09 8.310971800267897 -0.12474735405286486 RAETFAGYDCTNS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 4 RAETFAGYDCTNSPTK 16 1 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 RAETFAGYDCT(0.001)NS(0.999)PTK;RAETFAGYDCT(0.003)NS(0.997)PTK;RAETFAGYDCT(0.063)NS(0.921)PT(0.016)K;RAETFAGYDCT(0.003)NS(0.992)PT(0.004)K 243.37 1.6068e-21 48442100.0 184590.0 173119.0 170667.0 162467.0 172824.0 111940.3 126096.0 134763.3 109087.0 157599.0 True False 174331.22677231723 186396.67063467932 159686.47102817998 140338.71432879253 151112.3040538368 127359.06023213026 131959.71385448385 135155.43889173458 130907.44814544692 153048.7073786227 1.1390571652529173 1.2178911787445423 1.0433702692642566 0.9169545874151861 0.9873477969337207 0.8321472452365143 0.86220730716812 0.8830877516487449 0.8553319422789951 1.0 17.223631334614844 -5.584647263479989 1.9001901821699554 0.8931584776490047 1.18538732850577 0.7941905801839546 0.05567558119191382 0.14065349583529685 1.0065473005643286 0.01638219113981874 0.04061284520911677 2.6022722858472305e-06 5.584647263479989 0.2922288508567654 RAEVLGHKT(ph)PEPAPR ddPTM_A459_Selumetinib_30min_R2 1 RAEVLGHKTPEPAPR 15 2 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7ER34;K7EJ51 Q9UHD8 SEPT9 Septin-9 1 RAEVLGHKT(1)PEPAPR 81.904 0.015227 8278800.0 17834.0 16731.0 18705.0 18067.0 17749.0 15091.0 16468.0 13667.0 11992.0 16848.0 True False 16842.857675158484 18014.213901355823 17501.54066446414 15606.2434326866 15519.211941926767 17169.648267541532 17233.79463072293 13706.768707306352 14390.73508447569 16361.55446363892 1.0294167166444477 1.10100870558416 1.0696746879007535 0.9538362303758555 0.9485169625181927 1.0493897939647774 1.0533103482937658 0.8377424490911038 0.879545712875688 1.0 13.99802220059485 -6.349989978100615 0.5194286283914524 0.9232301629368294 1.083264286494881 0.30403210421480675 0.06788782445128151 1.5064839936657244 0.8225651116150009 0.06078485342262868 0.119288910548358 4.466939000638112e-07 6.349989978100615 0.16003412355805158 RAFS(ph)TEK ddPTM_A459_Selumetinib_30min_R1 1 RAFSTEK 7 1 H0YJD9;Q9NZ32 H0YJD9 ACTR10 Actin-related protein 10 1 RAFS(0.936)T(0.064)EK 79.986 0.02348 4812500.0 2733.8 3217.3 3756.2 3758.1 3335.8 3824.5 2934.8 2992.8 2002.5 2219.1 True False 2797.4922209512 2840.61702031781 3246.1286713296995 3101.8183832740183 3034.0774789833245 3786.029002368165 2713.425673178964 2913.4212220155346 3398.096243186703 2503.943100864461 1.1172347406717806 1.134457495993865 1.2964067235429617 1.2387735097507395 1.2117198182082651 1.5120267713196345 1.0836610753024625 1.163533317114796 1.357098027512504 1.0 11.289986063772337 -10.751594724053026 4.390343642193251 0.9999108968575467 1.2348621514555604 0.2514257278559585 0.12164181323613876 0.00011505546096904455 2.0212649270287672e-05 0.11792211296510362 0.028588592415358452 1.771761563733248e-11 10.751594724053026 0.2349512545980137 RAFS(ph)WLR ddPTM_A459_Selumetinib_30min_R1 1 RAFSWLR 7 1 Q9P206-2 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 RAFS(1)WLR 85.355 0.01865 7342400.0 2223.5 2414.7 2752.8 3148.0 2497.7 2485.2 2336.3 1889.7 1288.7 1508.7 True False 2275.30322382215 2131.9858014364268 2378.9848800480245 2598.260895278629 2271.7834760047504 2460.2011443810597 2160.0710100340802 1839.5790173893215 2186.8297770760064 1702.3563409824753 1.3365610765775464 1.2523734015676182 1.397465867031722 1.5262732206695946 1.334493502514076 1.4451740127223962 1.268871245128059 1.0806074927459965 1.284589908957562 1.0 10.733317341403447 -7.539864077998116 4.379589002543449 1.1390449141160428 1.3804983173643903 0.5983281858879352 0.09514397244343967 0.14987012106166717 7.010002979461088 0.04600650438254537 0.026809100814171698 2.884934265425386e-08 7.539864077998116 0.24145340324834752 RAGAES(ph)PTMSVDGR ddPTM_A459_Selumetinib_30min_R1 5 RAGAESPTMSVDGR 14 1 O75362 O75362 ZNF217 Zinc finger protein 217 1 RAGAES(0.998)PT(0.002)MSVDGR;RAGAES(0.993)PT(0.007)MSVDGR;RAGAES(0.949)PT(0.051)MSVDGR;RAGAES(0.76)PT(0.222)MS(0.019)VDGR;RAGAES(0.601)PT(0.396)MS(0.003)VDGR 223.14 7.185600000000001e-09 36544200.0 6783.599999999999 6761.199999999999 10911.400000000001 11899.7 9459.199999999999 7275.199999999999 7333.8 6333.799999999999 3756.4100000000003 4739.21 True False 6941.644681412159 5969.595560803396 9429.691812029938 9821.640780034013 8603.617030157404 7202.018093353079 6780.605561523744 6165.807048918074 6374.353412668646 5347.533767314614 1.2981020753606318 1.1163268565578717 1.7633720930696006 1.8366673699315739 1.6088943809471083 1.3467924480203397 1.267987423093689 1.1530188152536667 1.1920174214944084 1.0 12.384657972063351 -7.249997648933596 1.8465330594907596 1.1339556791015064 1.527780507137623 0.42981724508906594 0.20322679794574608 0.40762979759076157 2.7138038999277074 0.12074357969351801 0.0761907300188569 5.623443694504786e-08 7.249997648933596 0.3938248280361165 RAGDLLEDS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 RAGDLLEDSPK 11 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK 161.49 0.00031469 1330737200.0 39041.200000000004 57499.2 39255.0 38761.2 29818.7 39419.6 41591.5 39431.1 31385.0 48839.8 True False 39950.783999048945 50767.166933347115 33924.3866122803 31992.284057837995 27121.603849919054 39023.07461413311 38454.21966949125 38385.25913773615 53258.05273029445 55108.86406993826 0.7249429773828706 0.9212159929284492 0.6155885661012194 0.5805288241332069 0.49214594253837685 0.708108854586609 0.6977864689914363 0.696535117998834 0.9664153603802291 1.0 15.749996769511437 -8.272189464447079 3.765110245406656 0.9999492794392297 0.6754397708299993 0.5727646264992668 0.10518364018192572 0.17699746083204998 5.3669062263325875 0.10381602165908001 0.02996950561575234 5.343312022745534e-09 8.272189464447079 -0.32450950860923045 RAGDLLEDS(ph)PK ddPTM_A459_Selumetinib_30min_R2 8 RAGDLLEDSPK 11 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK;RAGDLLEDS(1)PK 137.62 0.0023663 2223694800.0 946981.0 764302.0 762165.0 652988.0 629141.0 545066.0 779526.0 702978.0 466828.0 618590.0 True False 894351.5870853001 822921.5057817262 713128.1336825094 564049.9079328695 550102.6829880982 620143.8938834933 815775.5036014642 705023.5495957278 560206.6442641434 600729.6994101625 1.4887753809465982 1.3698698542617866 1.1871031753261199 0.9389412717345127 0.9157241327143084 1.0323176871268274 1.3579743175715273 1.1736119427555656 0.9325436128997661 1.0 19.196356465307325 -5.278502061658714 2.4886279801012843 1.0641855224803902 1.4639947388995647 0.5805104446353062 0.12795619203083405 0.24180699139124226 2.858630424322994 0.03907739516909089 0.1263262472049423 5.266207149432688e-06 5.278502061658714 0.39980921641917444 RAGDPGEMPQS(ph)PTGLGQPK ddPTM_A459_Selumetinib_30min_R2 2 RAGDPGEMPQSPTGLGQPK 19 1 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9;H0YHL2 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 RAGDPGEMPQS(0.931)PT(0.069)GLGQPK;RAGDPGEMPQS(0.874)PT(0.126)GLGQPK 79.172 0.0036313 8374300.0 103652.0 102513.0 101606.0 110529.0 98508.0 77441.0 91225.0 91484.0 68724.0 98442.0 True False 97891.43679183167 110375.41746875198 95068.78058024839 95474.75952684003 86132.54436730646 88107.79481059453 95467.14325890817 91750.20329400839 82470.72030899847 95599.72367696735 1.0239719637957119 1.1545579131767356 0.9944461858643753 0.9986928398396886 0.9009706414879335 0.9216323167241764 0.9986131715348135 0.9597329339991971 0.8626669318382976 1.0 16.54471882777174 -5.616018296952111 2.1394077184371536 0.9430278947936332 1.0880490080261065 0.5207264869608207 0.05250297308360036 0.2309461182083086 2.1211452735774037 0.014969447380049903 0.03344755304042447 2.4209270502309152e-06 5.616018296952111 0.14502111323247324 RAGELTEDEVER ddPTM_A459_Selumetinib_30min_R1 2 RAGELTEDEVER 12 1 P62269 P62269 RPS18 40S ribosomal protein S18 0 ; 194.06 0.00014695 37915000.0 4446.5 4585.1 5501.6 6409.3 5469.2 4487.5 4463.0 4487.9 2786.3999999999996 3740.4 False True 4550.094798617129 4048.274360444839 4754.512938125622 5290.036072461662 4974.511825665682 4442.359824323999 4126.3523168180855 4368.866313246298 4728.31728939597 4220.51677458133 1.078089495111293 0.9591892596722171 1.1265238813313956 1.2534095597775292 1.178649935862214 1.052563006283674 0.9776888796342753 1.0351496147482282 1.1203171417000264 1.0 12.043203942950031 -6.948711763227744 10.394652511211806 1.03321281392488 1.1179946938231757 0.21997298328540815 0.0778960268625693 0.8508373040453829 167.57959140826983 0.03100382445344008 0.027332587731021426 1.125351610439208e-07 6.948711763227744 0.08478187989829578 RAGELTEDEVER ddPTM_A459_Selumetinib_30min_R2 1 RAGELTEDEVER 12 1 P62269 P62269 RPS18 40S ribosomal protein S18 0 175.21 0.00015033 17030000.0 62868.0 61795.0 67560.0 76498.0 72509.0 57921.0 48764.0 46178.0 41742.0 62709.0 False True 59374.0482405441 66534.47779775776 63213.26315376621 66078.84043358939 63399.7711813154 65899.0919955121 51031.622624032876 46312.370334820545 50091.56636892799 60898.4282324509 0.9749684838155724 1.0925483584534221 1.0380114066734125 1.085066435234826 1.0410740149042403 1.082114824769755 0.8379793059558752 0.7604854785093141 0.8225428442541599 1.0 15.894117372697297 -7.26632016320087 24.799125504231416 0.8352923464586747 1.0544568565945605 0.6813823622245012 0.06543338398072211 186.38678898631233 947020.7301167859 0.025263371682674157 0.01765447330946613 5.4160147295578116e-08 7.26632016320087 0.21916451013588578 RAGGFISFNGS(ph)WR ddPTM_A459_Selumetinib_30min_R2 1 RAGGFISFNGSWR 13 1 Q5SGD2-2;Q5SGD2-3;Q5SGD2 Q5SGD2-2 PPM1L Protein phosphatase 1L 1 RAGGFIS(0.37)FNGS(0.63)WR 67.846 0.0472 5035400.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RAHT(ph)PTPGIYMGR ddPTM_A459_Selumetinib_30min_R2 2 RAHTPTPGIYMGR 13 1 Q13595;Q13595-4;Q13595-3;Q13595-2 Q13595 TRA2A Transformer-2 protein homolog alpha 1 RAHT(0.973)PT(0.027)PGIYMGR;RAHT(0.852)PT(0.148)PGIYMGR 95.428 0.008331 7645500.0 17485.2 19908.1 21740.6 18936.7 23504.4 17046.800000000003 10898.3 12863.9 13664.2 22900.0 True False 16513.44258280144 21434.987255369197 20341.833465375526 16357.488792370432 20551.567139997936 19394.841964556806 11405.092544571758 12901.331819266708 16397.4218096475 22238.817498654516 0.7425503889224564 0.963854631959008 0.9146994199042391 0.7355377053370794 0.9241303923304978 0.8721166026804359 0.5128461774220587 0.5801267005337518 0.7373333501495559 1.0 14.440792457440802 -7.223616323868401 24.701218583229114 0.6725870865531725 0.863495027155043 0.2054076597576655 0.13888952041751973 583.0681381995166 380786.4385199228 0.051020180186316676 0.03951917468725164 5.975629686367595e-08 7.223616323868401 0.19090794060187055 RAHT(ph)PTPGIYMGRPTHSGGGGGGGGGGGGGGGGR ddPTM_A459_Selumetinib_30min_R2 1 RAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGR 34 2 Q13595;Q13595-4;Q13595-3 Q13595 TRA2A Transformer-2 protein homolog alpha 1 RAHT(0.339)PT(0.339)PGIY(0.042)MGRPT(0.123)HS(0.157)GGGGGGGGGGGGGGGGR 56.00899999999999 0.00053369 3425600.0 1020.5 0.0 3888.3 1579.9 2881.9 2852.6 1373.2 565.57 0.0 3321.7 True False 963.7846953851755 0.0 3638.1310112609444 1364.7148945204835 2519.8499574871116 3245.5197566754305 1437.0565209441788 567.2157150648461 0.0 3225.79389018693 0.298774419009556 0.0 1.1278250052888903 0.4230632647274932 0.7811565286773762 1.0061150424236673 0.4454892562465928 0.17583755638894114 0.0 1.0 11.655438546123841 -5.217417850072413 24.999875005069363 0.5967905407742381 0.14938704344974213 0.21508615038313839 0.35737655541526886 772.5658643324731 438738.5033202422 0.09461831317605592 0.25034274069484974 6.06152847858197e-06 5.217417850072413 -0.44740349732449597 RAIS(ph)ETEENSDELSGER ddPTM_A459_Selumetinib_30min_R1 2 RAISETEENSDELSGER 17 1 A7UKX8;F5GWH7;J3KN53;E7EPE2;Q00987-8;Q00987-9;Q00987;Q00987-11 A7UKX8 mdm2;MDM2 E3 ubiquitin-protein ligase Mdm2 1 RAIS(0.987)ET(0.013)EENSDELSGER;RAIS(0.568)ET(0.421)EENS(0.011)DELSGER 184.21 1.1209000000000002e-07 5140800.0 1488.96 1520.37 2063.14 2346.1000000000004 1954.01 1574.15 1656.22 1635.1599999999999 1200.3600000000001 1315.8899999999999 True False 1523.6498709881844 1342.3643735991632 1782.9769200168123 1936.3976767513323 1777.2701405084847 1558.3154802138438 1531.2899919696283 1591.7902450517645 2036.9232491743282 1484.797299354032 1.0261669196536491 0.904072477895242 1.2008217692694516 1.3041495142763064 1.1969782954762205 1.0495139510906952 1.0313124846306112 1.0720589576397266 1.3718527438462484 1.0 10.536050276174956 -5.2642080184182385 24.88525845606982 1.1547884433745645 0.9651196936474088 0.2912183589988384 0.11743546771706695 271.56992073038145 2440968.6093776566 0.031641880017808766 0.07091828964654925 5.442419093529216e-06 5.2642080184182385 -0.18966874972715575 RAIS(ph)PTSSSR ddPTM_A459_Selumetinib_30min_R2 2 RAISPTSSSR 10 1 A0A0U1RRL2;B1AM27;O14795;O14795-2 A0A0U1RRL2 UNC13B Protein unc-13 homolog B 1 RAIS(0.993)PT(0.005)S(0.001)S(0.001)S(0.001)R;RAIS(0.998)PT(0.002)SSSR 71.241 0.036795 2494000.0 3455.7 4950.1 6240.5 6674.9 8077.200000000001 3378.1 3730.5 5075.0 5481.0 5086.299999999999 True False 3263.646028263158 5329.7567529198195 5838.993024142665 5765.767105155246 7062.46992491582 3843.4026116613886 3903.975641845513 5089.767409788525 6577.353151935562 4939.44530320552 0.6607312821431934 1.0790192877449218 1.1821151294768608 1.167290404332137 1.4298103311990387 0.7781040938275318 0.7903672178153234 1.0304329934548422 1.3315975272905847 1.0 12.270133321766133 -4.761722812336887 7.714966217388807 1.086151282175944 0.6546272898379247 0.2976840631171448 0.196735076854797 0.13586700903754537 63.46536861013135 0.05232348914890847 0.3072051142230061 1.7309207637645192e-05 4.761722812336887 -0.4315239923380193 RALELEQER ddPTM_A459_Selumetinib_30min_R1 1 RALELEQER 9 1 P26038 P26038 MSN Moesin 0 142.98 0.0028045 4310600.0 3176.1 3691.5 4331.8 4240.8 3872.8 2757.9 4176.3 3623.3 2027.4 3317.3 False True 3250.096950385215 3259.2974638682103 3743.565352874179 3500.2238896752237 3522.5059237983724 2730.158029972847 3861.2783286415797 3527.1983138629002 3440.349724562659 3743.1077682383266 0.8682883720216412 0.8707463598896542 1.000122247251264 0.9351117056730069 0.9410645222903162 0.7293826945457628 1.031570173160916 0.9423181303494654 0.9191158624272903 1.0 11.870020870293711 -8.595587740172064 0.6749708385998036 0.9973737836195252 0.9068728431413126 0.10997940529598382 0.07764154667600832 2.1467830609762744 2.2001252844318357 0.08003593676232716 0.031732111241690786 2.537536277719255e-09 8.595587740172064 -0.09050094047821267 RALLETAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 RALLETASPR 10 1 Q96BT3;H3BMP6;H3BQS6;H3BN05;H3BTS2;H3BQJ0;I3L4F8;H3BUW2;H3BTR4;Q96BT3-3;Q96BT3-2 Q96BT3 CENPT Centromere protein T 1 RALLET(0.006)AS(0.994)PR;RALLET(0.005)AS(0.995)PR;RALLET(0.048)AS(0.952)PR 105.66 0.0063534 14159000.0 8823.8 9999.0 10742.699999999999 13105.300000000001 10665.2 9727.6 9422.7 8952.5 5399.3 8203.1 True False 9029.377371874014 8828.312431591012 9283.900345427175 10816.705371948863 9700.53454309399 9629.749175954123 8711.93815274071 8715.050618181664 9162.217750730573 9256.047789960454 0.9755111011492078 0.9537885533787559 1.0030091196695128 1.1686094991515896 1.0480212249569032 1.0403737528666395 0.9412157705354642 0.941552033432068 0.9898628398038682 1.0 13.176180597914854 -7.253517791786406 24.360764526379285 0.9632869971749407 1.0336985554832487 0.2283615998415347 0.056725266639110324 661.3989463148881 2033964.2552240028 0.02444037993331398 0.018573102582445915 5.578047500289342e-08 7.253517791786406 0.07041155830830803 RALLETAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 RALLETASPR 10 1 Q96BT3;H3BMP6;H3BQS6;H3BN05;H3BTS2;H3BQJ0;I3L4F8;H3BUW2;H3BTR4;Q96BT3-3;Q96BT3-2 Q96BT3 CENPT Centromere protein T 1 RALLETAS(1)PR;RALLETAS(1)PR 112.02 0.0043593 19167900.0 71136.0 71582.0 82489.0 84043.0 76645.0 70279.0 58874.0 57544.0 49972.0 79024.0 True False 67182.54589997054 77072.10922759256 77181.7475472323 72596.19841773846 67016.16988500641 79959.29432075753 61611.75765661785 57711.443513077975 59967.796334341154 76742.37179099025 0.8754296268421814 1.0042966802941713 1.0057253345966255 0.9459728273118272 0.8732616456985016 1.0419184663529641 0.8028388518460049 0.7520153751601074 0.7814170312283928 1.0 16.22773573294758 -7.28147000634938 24.435811808035027 0.8134024039168111 0.9576850107084296 0.34895691579913957 0.0808256849107039 592.0954848283941 722307.0839974046 0.03248249158151004 0.02193328033809353 5.2303408720284684e-08 7.28147000634938 0.14428260679161853 RALS(ph)SDSILSPAPDAR ddPTM_A459_Selumetinib_30min_R1 3 RALSSDSILSPAPDAR 16 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 RALS(0.756)S(0.224)DS(0.02)ILSPAPDAR;RALS(0.955)S(0.015)DS(0.03)ILSPAPDAR;RALS(0.997)S(0.001)DS(0.002)ILSPAPDAR 263.47 3.8615e-39 244954000.0 7106.6 6877.4 11175.8 11235.1 9948.0 7536.800000000001 7381.3 7871.8 3650.29 5680.9 True False 7272.169952963566 6072.190810783479 9658.187744275187 9273.100693946924 9048.205156462049 7460.986634866875 6824.522598281278 7663.0142927899915 6194.275523366783 6410.098851651981 1.1344863973649044 0.9472850499362552 1.5067143218526378 1.4466392654080684 1.411554699211883 1.1639425237481422 1.0646516935573456 1.1954596130471709 0.9663307332258102 1.0 12.646130889819435 -6.977603309454585 6.252170208130511 1.0779643601477338 1.2916059384394336 0.3132612215948588 0.16141591258753463 0.24646601620119918 33.76053746226177 0.0641810661122151 0.05529770596237903 1.0529231892214544e-07 6.977603309454585 0.21364157829169983 RALS(ph)SDSILSPAPDAR ddPTM_A459_Selumetinib_30min_R2 6 RALSSDSILSPAPDAR 16 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 RALS(0.689)S(0.222)DS(0.089)ILSPAPDAR;RALS(0.926)S(0.061)DS(0.013)ILSPAPDAR;RALS(0.759)S(0.195)DS(0.046)ILSPAPDAR;RALS(0.707)S(0.253)DS(0.04)ILSPAPDAR;RALS(0.631)S(0.234)DS(0.136)ILSPAPDAR;RALS(0.947)S(0.045)DS(0.007)ILSPAPDAR 163.78 1.5109e-05 188012500.0 180863.0 222051.0 199635.0 233366.0 195743.0 114022.2 87516.5 91017.4 74029.5 188094.0 True False 170811.35851195393 239081.59769350092 186790.70144615325 201581.14822119588 171152.01437537733 129727.7230595236 91586.19066065493 91282.24556525817 88837.46855705405 182663.23749309726 0.9351162327800568 1.308865434417452 1.0225960297742558 1.1035671489662144 0.9369811721520871 0.7102015974310427 0.5013936680286635 0.49972970378731885 0.48634563679191967 1.0 17.478826783152513 -6.704283686655732 2.0220259941830907 0.5800361872568566 1.1041533169885245 0.6235382608760017 0.16667689295592844 0.18492828866909403 1.554995266380374 0.062009103151923255 0.059242523514916795 1.9756786801870607e-07 6.704283686655732 0.5241171297316679 RALSSDS(ph)ILSPAPDAR ddPTM_A459_Selumetinib_30min_R1 1 RALSSDSILSPAPDAR 16 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 RALS(0.121)S(0.001)DS(0.878)ILSPAPDAR 206.13 1.4749e-07 86162000.0 1981.4 2270.6 3431.1 4602.4 3124.5 2372.1 2346.8 2672.3 1103.8 1806.2 True False 2027.562764866745 2004.7570964266981 2965.1754656832227 3798.677237747891 2841.8895266752784 2348.2388276944757 2169.778986580481 2601.421923146256 1873.0679816376953 2038.043363877873 0.9948575191299237 0.983667537187315 1.4549128434839853 1.8638844025968044 1.3944205393490219 1.1522025827882192 1.0646382825005005 1.2764310952620843 0.9190520745710377 1.0 10.992969033018609 -6.868447953488782 4.727125136522718 1.0912078819234436 1.3535842109559841 0.2127016477525796 0.24728471922376793 0.40707774418586445 15.183019416272945 0.1001298808686839 0.08842847236048602 1.35379232148102e-07 6.868447953488782 0.2623763290325405 RALVEFESNPEET(ph)REPGSPPSVQR ddPTM_A459_Selumetinib_30min_R1 1 RALVEFESNPEETREPGSPPSVQR 24 2 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 RALVEFES(0.015)NPEET(0.586)REPGS(0.382)PPS(0.017)VQR 57.484 0.015977 34591000.0 751.11 458.14 2086.6 2016.7 1231.1 879.03 752.34 701.03 498.87 416.69 True False 768.6094015943575 404.50075581649224 1803.2511808733677 1664.521203147525 1119.7472223683578 870.1877562953819 695.5903880875914 682.4364071336375 846.5459539768041 470.1762204043134 1.6347262329290402 0.8603173411633928 3.835266656664852 3.540207120037189 2.3815479681330247 1.850769389287895 1.4794248579595115 1.4514481539427868 1.8004865351311115 1.0 8.87705776497939 -6.897182061373034 2.9305765069332965 1.482655362180522 2.503458959945801 0.25732586767890087 0.8152670504352476 0.42961402347391914 7.432005605573808 0.34930112452460826 0.30073929559590584 1.2671205626049547e-07 6.897182061373034 1.0208035977652787 RALVEFESNPEET(ph)REPGSPPSVQR ddPTM_A459_Selumetinib_30min_R2 1 RALVEFESNPEETREPGSPPSVQR 24 2 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 RALVEFESNPEET(0.812)REPGS(0.177)PPS(0.011)VQR 66.545 0.0082164 8083000.0 4742.9 10858.0 9677.5 9086.1 10480.0 4041.4 1161.4 2886.5 1271.1 8957.8 True False 4479.308605333024 11690.773686027222 9054.860186065314 7848.55750560324 9163.408707611272 4598.066165823493 1215.4074012704411 2894.8992371141994 1525.3555175014221 8699.165038840496 0.5149124755460517 1.3438960674765488 1.0408884238471958 0.9022196349374431 1.0533664629533979 0.5285640800345552 0.1397154089896933 0.3327789763947343 0.17534504871340334 1.0 13.086661219861172 -6.8713387972185425 4.187810800290071 0.35366082961846346 0.9917573784732483 0.4498857402266879 0.2942721866310284 0.1743972590944217 5.501169655166857 0.10114481750760912 0.08920093356429384 1.3448108451281922e-07 6.8713387972185425 0.6380965488547848 RALVEFESNPEETREPGS(ph)PPSVQR ddPTM_A459_Selumetinib_30min_R1 1 RALVEFESNPEETREPGSPPSVQR 24 2 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 RALVEFESNPEET(0.343)REPGS(0.654)PPS(0.002)VQR 137.39 7.8342e-08 28775000.0 784.47 824.9 2274.7 2142.7 1304.1 997.27 908.43 817.88 696.44 493.71 True False 802.7466246870977 728.3203245143937 1965.8082340327085 1768.5176684604571 1186.1443852575544 987.2383692487115 839.9063937188115 796.1871655513453 1181.8078140349296 557.0824876426444 1.4409834135767001 1.3073832702879622 3.5287561135716925 3.1746064679651544 2.1292078131496366 1.772158326904726 1.5076876626888192 1.4292087495345591 2.1214233802894773 1.0 9.121747154147926 -6.755667379440036 3.139145599456276 1.5669014817619453 2.3939532021539645 0.23785068265678455 0.6832895434443473 0.4140707071179027 8.448300915648826 0.27312016756183877 0.2550691113577935 1.7552242908981688e-07 6.755667379440036 0.8270517203920191 RALYESVFGSGEICGPT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 RALYESVFGSGEICGPTSPK 20 1 A0A2U3U043 A0A2U3U043 1 RALYESVFGSGEICGPT(0.5)S(0.5)PK 132.36 0.00018114 15161000.0 3679.4 3381.1 4628.3 4790.7 3593.2 3452.8 3017.0 3257.2 2456.9 3252.6 True False 3765.1228611338965 2985.239240169253 3999.8022814320975 3954.0941775766587 3268.1956944309836 3418.0679668915654 2789.4252609993655 3170.8084751232973 4169.179855123803 3670.102893006959 1.0258902736236604 0.8133938821871588 1.0898338270170436 1.0773796519740138 0.8904915719551698 0.9313275585282301 0.7600400703518031 0.863956288845465 1.1359844605631597 1.0 11.841604794910419 -6.294645356534522 24.547930393577253 0.9150361829626138 0.9944801003578759 0.07371778477103996 0.11544751434462681 1322.1664187601834 977423.9181498411 0.03687304292483278 0.04181278460478213 5.074048843272742e-07 6.294645356534522 0.07944391739526213 RAMLDSGIYPPGS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 RAMLDSGIYPPGSPGK 16 1 O95295 O95295 SNAPIN SNARE-associated protein Snapin 1 RAMLDS(0.007)GIYPPGS(0.992)PGK 116.96 0.0046348 0.0 718.07 948.47 1132.5 1132.7 842.18 933.21 799.72 915.59 477.14 779.46 True False 734.7996338790064 837.4226914682599 978.7127203772122 934.8952084123579 766.0049676989553 923.8227546868859 739.3964765417339 891.3055789445352 809.6717310732098 879.51128358335 0.8354635666358344 0.9521454779481503 1.11279154531104 1.0629712499006947 0.8709438775794422 1.0503819245194899 0.8406901541151888 1.0134100557677126 0.9205927725843422 1.0 9.780558276471755 RAPFDLFENK ddPTM_A459_Selumetinib_30min_R1 2 RAPFDLFENK 10 1 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 ; 152.64 0.00084705 23735000.0 11408.2 16970.7 14540.2 17191.300000000003 13577.5 12987.9 13412.5 11293.6 7861.4 11367.3 False True 11673.98886350701 14983.762554535615 12565.720703601526 14189.162175668198 12349.41752230232 12857.253518069676 12400.784326534305 10994.057041217136 13340.221626061404 12826.403681878495 0.9101529277454716 1.1681967078351898 0.9796760662815198 1.10624634368206 0.9628121668858688 1.0024051820725686 0.9668169374751929 0.8571426031717566 1.040059392868544 1.0 13.646829098096909 -6.295258931331136 23.275218816386023 0.9657036418081261 1.0457634987163607 0.15586026244506024 0.07826427324760342 432.39427362453705 297579.8261214941 0.022872294163916642 0.02593689816461631 5.066885247145798e-07 6.295258931331136 0.08005985690823458 RAPFDLFENK ddPTM_A459_Selumetinib_30min_R2 1 RAPFDLFENK 10 1 P08238;Q58FF7 P08238 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 100.55 0.023409 1536300.0 8125.4 11590.0 11549.0 11554.0 12799.0 8021.0 9479.6 8400.7 8803.7 11473.0 False True 7673.822796553362 12478.91573227625 10805.94991360045 9980.325268238284 11191.075195488242 9125.819942611528 9920.420183471051 8425.144646189252 10564.68599593051 11141.744679566074 0.6887451666907365 1.1200145121941758 0.9698615633706389 0.895759645842735 1.0044275396125921 0.8190656136061216 0.8903830117077688 0.7561782188063366 0.9482075114596829 1.0 13.443687540726195 -6.765855484715449 24.999802559111416 0.8680040241402031 0.9456700547638082 0.036851909257336724 0.11924406114838768 285.27709919293864 1614957.70311913 0.039267073794441075 0.03581450361543199 1.7145277366847254e-07 6.765855484715449 0.07766603062360511 RAPFDLFENR ddPTM_A459_Selumetinib_30min_R1 2 RAPFDLFENR 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ; 164.65 0.00050316 131633000.0 7573.9 11524.4 9503.5 12088.599999999999 8840.6 8721.8 8484.1 6895.5 3412.8 6302.6 False True 7750.35713375605 10175.117890451798 8212.976898988816 9977.552941126176 8040.9692909346995 8634.066610760787 7844.137506411901 6712.608940259333 5791.272338950101 7111.600102522799 1.0898190311638383 1.430777566759165 1.154870462425933 1.4029969060811922 1.1306835557418664 1.2140821314879477 1.1030059892750774 0.9438957257844229 0.8143416749341236 1.0 12.79595848589279 -7.53755946105931 1.5532381271836229 0.892687854588672 1.254216670247422 0.6206822197290602 0.1112316765630041 0.24051758815283708 1.1191186819053847 0.07118929681892307 0.033645969526340684 2.9002840815820478e-08 7.53755946105931 0.36152881565875006 RAPFDLFENR ddPTM_A459_Selumetinib_30min_R2 5 RAPFDLFENR 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 ;;;; 152.7 0.00084406 12155200.0 69920.84 89317.26 82849.8 78666.6 79541.8 57806.560000000005 57133.87 63047.74 52632.31 81923.74 False True 66034.91962809951 96167.60664174343 77519.33406804179 67952.07337254568 69549.04797128568 65768.88892429501 59790.708163615614 63231.19848528476 63160.242669613166 79558.3887627609 0.830018313028087 1.2087676502412636 0.9743703369760358 0.854115756104304 0.8741887443029727 0.8266744707514694 0.7515324165489135 0.7947772631976875 0.7938853922488781 1.0 16.279726438180724 -5.7172552044097 3.455559941584539 0.8284334783827094 1.0339468728894965 0.3268896703960773 0.10616558161857237 0.22018806794617707 5.380307118508127 0.0286464049666978 0.050726178665152125 1.917541604810493e-06 5.7172552044097 0.20551339450678707 RAPPGGCEER ddPTM_A459_Selumetinib_30min_R2 1 RAPPGGCEER 10 1 Q5RKV6 Q5RKV6 EXOSC6 Exosome complex component MTR3 0 94.363 0.032364 195700.0 0.0 663.68 0.0 498.28 537.35 533.98 387.92 0.0 507.8 614.88 False True 0.0 714.5821219324505 0.0 430.4134044190557 469.84328903004985 607.5308980121808 405.9590486488972 0.0 609.3741891174749 597.1268167498987 0.0 1.1967007709046618 0.0 0.7208073600876823 0.7868400410943854 1.0174235706225865 0.6798539895737584 0.0 1.0205105046767744 1.0 9.22189355085721 RAPS(ph)PDGFSPYSPEETNR ddPTM_A459_Selumetinib_30min_R1 3 RAPSPDGFSPYSPEETNR 18 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 RAPS(0.997)PDGFS(0.003)PYSPEETNR;RAPS(1)PDGFSPYSPEETNR;RAPS(1)PDGFSPYSPEETNR 86.825 0.01009 11322500.0 3565.64 4466.700000000001 3153.48 3296.46 4132.68 3141.5299999999997 3952.6 3493.0 2029.31 3316.8199999999997 True False 3648.7124744723224 3943.736687487507 2725.2547368257206 2720.795143217976 3758.879823683913 3109.929060481018 3654.4521997434854 3400.3542931369493 3443.5908550617783 3742.566155562729 0.9749226393898454 1.0537520309763315 0.7281781065579999 0.7269865194430691 1.0043589525056054 0.8309616800917743 0.9764562730071514 0.908562240932699 0.9201148922761001 1.0 11.86981210300556 -7.274885986802086 24.560650725046823 0.9436635337601665 0.8850343333773791 0.08240884966279127 0.1045593504563864 2124.4164913949935 3880296.500125991 0.04658082764748795 0.031617229350295505 5.3102383301317414e-08 7.274885986802086 -0.058629200382787405 RAPS(ph)PDGFSPYSPEETNR ddPTM_A459_Selumetinib_30min_R2 2 RAPSPDGFSPYSPEETNR 18 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 RAPS(1)PDGFSPYSPEETNR;RAPS(1)PDGFSPYSPEETNR 155.54 1.328e-05 5852300.0 20688.9 18573.4 24522.0 25276.0 26699.0 14213.099999999999 20603.0 18994.5 16393.1 20882.0 True False 19539.093762228676 19997.9200571061 22944.281217534866 21833.365196467967 23344.832927911597 16170.825511324256 21561.080324069997 19049.770850291257 19672.178061484192 20279.0824020482 0.9635097572390758 0.9861353517201695 1.1314260064951203 1.0766446313302018 1.1511779707327268 0.7974140639465518 1.063217748052166 0.939380316752755 0.9700723963475433 1.0 14.307704753588709 -6.733133051940475 24.999542399468847 0.9570529390052189 1.0622714524740702 0.3003226768857272 0.082174091871953 286.9989045765776 253470.60900344633 0.027106264843024933 0.027101073607477714 1.8487021575051796e-07 6.733133051940475 0.10521851346885125 RAPS(ph)PGAYK ddPTM_A459_Selumetinib_30min_R2 2 RAPSPGAYK 9 1 P54259 P54259 ATN1 Atrophin-1 1 RAPS(1)PGAYK;RAPS(1)PGAYK 98.182 0.01023 94955000.0 210562.0 198084.0 244188.0 251970.0 256842.0 186645.0 185270.0 190167.0 167036.0 204788.0 True False 198859.80698647082 213276.4058595517 228477.2099317921 217651.25132750534 224575.21176338696 212353.65455538305 193885.42210554032 190720.35448615838 200447.86737579104 198875.2383368756 0.9999224068791378 1.0724130748659715 1.1488469446597147 1.0944110144010235 1.1292266128324033 1.0677732247172789 0.9749098164604937 0.9589949763534481 1.0079076161118237 1.0 17.601504133954656 -7.177726502570227 4.190922237533248 0.981881421483712 1.0920438224903901 0.6134171005873892 0.03899282058752481 0.15497597735192178 5.007681434955875 0.016339427909451917 0.012326607539684342 6.641611949771643e-08 7.177726502570227 0.11016240100667807 RAPS(ph)PLPK ddPTM_A459_Selumetinib_30min_R1 1 RAPSPLPK 8 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 RAPS(1)PLPK 94.363 0.040883 14425000.0 3827.3 4811.2 4650.7 5136.4 4373.6 3894.3 4471.4 4170.2 2317.8 3641.9 True False 3916.4686433705906 4247.9024673338 4019.1604844664876 4239.42416216936 3978.0086522217966 3855.126877741493 4134.118698055207 4059.5927492813394 3933.1373145858383 4109.373340110081 0.9530573932388624 1.033710523663447 0.9780470528771239 1.0316473611170591 0.968032914749779 0.9381301134440666 1.0060216864950176 0.9878860870724858 0.9571136494695998 1.0 12.004702691209948 -6.3403505721122375 24.999919683905485 0.9751795326996012 1.0000842963993881 0.1309039159051566 0.02881490933321687 210.19064142991556 66588.8984014238 0.00862968500354711 0.009785143361344369 4.5671936679857875e-07 6.3403505721122375 0.02490476369978689 RAPS(ph)PLPK ddPTM_A459_Selumetinib_30min_R2 1 RAPSPLPK 8 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 RAPS(1)PLPK 108.47 0.023097 20380000.0 50486.0 44661.0 50931.0 51576.0 51032.0 42854.0 51450.0 48855.0 39318.0 53085.0 True False 47680.1902314708 48086.35509225104 47654.15490947998 44551.25982643742 44620.90392813155 48756.74951012024 53842.526946240876 48997.15996161936 47182.698636709094 51552.29811860589 0.9248897133891768 0.9327684089197966 0.92438468601036 0.8641954180963718 0.8655463588737141 0.9457725705640908 1.044425348844117 0.9504359989712206 0.9152394822080735 1.0 15.653749121602882 -6.9939156444585535 22.94393311529764 0.9764954552423029 0.903401021963196 0.4685515694277175 0.03785881652641892 55.85884074960039 210637.9111943186 0.014274112533277454 0.012542513943050539 1.0141083427656686e-07 6.9939156444585535 -0.07309443327910681 RAPS(ph)PVVSPTEMNK ddPTM_A459_Selumetinib_30min_R1 3 RAPSPVVSPTEMNK 14 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 RAPS(1)PVVSPTEMNK;RAPS(1)PVVSPTEMNK;RAPS(1)PVVSPTEMNK 135.86 0.0010772 41607100.0 11201.0 13553.2 12371.9 12382.5 12047.6 10705.3 12465.6 12391.500000000002 6140.1 10797.1 True False 11461.961506648033 11966.385043288255 10691.86393398218 10220.128823312452 10957.896707176538 10597.614401634692 11525.309755887858 12062.837166735331 10419.30124483929 12183.012957660161 0.9408150140266607 0.9822188554567941 0.8776042487305729 0.8388835223955392 0.8994406182820874 0.8698681055716486 0.9460147334605955 0.9901357906010214 0.8552318938713822 1.0 13.572583347073957 -7.315162505077481 14.137548586706203 0.9470328014157142 0.9011213906348083 0.16215606801836457 0.05162403871925415 6.55555870350006 1722.5138095172515 0.022456054426211604 0.015140078714472345 4.839912330018656e-08 7.315162505077481 -0.04591141078090588 RAPS(ph)PVVSPTEMNK ddPTM_A459_Selumetinib_30min_R2 4 RAPSPVVSPTEMNK 14 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 RAPS(1)PVVSPTEMNK;RAPS(1)PVVSPTEMNK;RAPS(1)PVVSPTEMNK;RAPS(1)PVVSPTEMNK 129.42 0.00054136 133533000.0 628658.0 521941.0 577628.0 614120.0 592322.0 469630.0 581768.0 531612.0 458406.0 590702.0 True False 593719.7050773678 561972.1963951688 540464.043353813 530475.7965839098 517909.214934134 534317.2696233201 608821.3647514227 533158.9029068955 550100.0089338032 573646.8984318887 1.0349915718194413 0.9796482782899486 0.942154563776456 0.9247427259417061 0.9028362505748427 0.9314393071485624 1.0613172779556315 0.9294200044737094 0.9589522935407603 1.0 19.129803450654563 RAPS(ph)VANVGSHCDLSLK ddPTM_A459_Selumetinib_30min_R2 2 RAPSVANVGSHCDLSLK 17 1 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 RAPS(0.919)VANVGS(0.079)HCDLS(0.001)LK;RAPS(1)VANVGSHCDLSLK 113.14 0.0033197 163529800.0 58116.0 45547.9 63858.5 68239.0 70289.0 60821.0 63683.0 52446.0 57796.3 64111.0 True False 54886.14537678088 49041.2774704181 59749.913633877724 58944.73048115916 61458.66742836723 69198.54067193305 66644.3856854706 52598.609177097285 69357.17496354927 62259.94884961743 0.8815642542423665 0.787685797636492 0.9596845923885604 0.9467519901684172 0.9871300661813004 1.111445511127468 1.0704214654342765 0.8448225568598502 1.1139934459482848 1.0 15.926016771094197 -5.616465301129246 1.446999068250141 1.0184705545183814 0.8315017055919608 0.4378487037033282 0.07841910291214425 0.42523748174764975 1.7239754431259957 0.02528272224492362 0.07246891044499755 2.4184365562850427e-06 5.616465301129246 -0.18696884892642063 RAPSS(ph)PVAK ddPTM_A459_Selumetinib_30min_R1 1 RAPSSPVAK 9 1 Q9GZR2;A0A0C4DG31;Q9GZR2-2 Q9GZR2 REXO4 RNA exonuclease 4 1 RAPS(0.009)S(0.991)PVAK 66.267 0.044027 3206200.0 2795.1 4549.9 3088.8 2938.7 2955.1 3590.1 3043.2 3222.0 3307.6 3717.7 True False 2860.220391682162 4017.195592808874 2669.357925563913 2425.511211231037 2687.811726765279 3553.986853549992 2813.648973905622 3136.542093469011 5612.755622454101 4194.903008464606 0.6818323059938979 0.9576373004817638 0.6363336458977954 0.5782043604671586 0.6407327467027794 0.8472155009016052 0.6707304002567291 0.7477031261843239 1.337994135055926 1.0 12.034421738753936 -8.22212465601061 10.53746344763444 1.168730968020021 0.7202429652510163 0.6577389352507232 0.12954223471608858 0.3878124253559172 103.48628231825401 0.08749418922546336 0.03279754992489635 5.996189422851265e-09 8.22212465601061 -0.4484880027690048 RAPSS(ph)PVAK ddPTM_A459_Selumetinib_30min_R2 1 RAPSSPVAK 9 1 Q9GZR2;A0A0C4DG31;Q9GZR2-2 Q9GZR2 REXO4 RNA exonuclease 4 1 RAPS(0.011)S(0.989)PVAK 65.232 0.045606 2681500.0 19599.0 15747.0 14528.0 19810.0 20829.0 15133.0 26145.0 34303.0 30253.0 25400.0 True False 18509.76604101328 16954.74426541452 13593.284296890399 17111.84382584391 18212.274806377405 17217.433386303484 27360.794305334653 34402.81605083266 36304.44533944657 24666.636002874442 0.7503968534199924 0.6873553517163328 0.5510797781791709 0.6937242607321825 0.7383363829690883 0.6980049239100585 1.1092227696612647 1.394710492619409 1.4718036677241255 1.0 14.590273356116024 -7.385967803393059 2.7731682828353916 1.3219396991065224 0.6782867472296313 0.8267290445414899 0.12649098704819528 0.10142699580845126 1.5072628887895507 0.05983294527603086 0.03687380733422418 4.1118020299461455e-08 7.385967803393059 -0.6436529518768911 RAQCETLS(ph)PDGLPEEQPQTTK ddPTM_A459_Selumetinib_30min_R2 1 RAQCETLSPDGLPEEQPQTTK 21 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659;A0A087X146 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 RAQCET(0.103)LS(0.897)PDGLPEEQPQTTK 72.122 0.0024951 9599600.0 32632.0 36550.0 33694.0 44837.0 46054.0 23415.0 19092.0 26666.0 25278.0 37370.0 True False 30818.44407624602 39353.267473226675 31526.164723253383 38730.123251860845 40268.284792016195 26640.20370979292 19979.81583008029 26743.593645206063 30334.30632633228 36291.031001079435 0.84920277066059 1.0843799800577767 0.8687040255846045 1.0672092300356213 1.1095932984328403 0.734071283590718 0.5505441779674436 0.7369201950865106 0.8358623464136365 1.0 15.14732542283724 -6.776528375893922 24.985083340251528 0.7412285683806402 0.9976422785515981 0.4079915020898174 0.13262878583840462 210.7780527225712 349014.2266979271 0.04595412230296959 0.04068319603137161 1.6729063286239971e-07 6.776528375893922 0.25641371017095793 RAQS(ph)TDSLGTSGSLQSK ddPTM_A459_Selumetinib_30min_R2 2 RAQSTDSLGTSGSLQSK 17 1 Q15276-2;Q15276;I3L456 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 1 RAQS(0.994)T(0.006)DSLGTSGSLQSK;RAQS(0.919)T(0.08)DS(0.002)LGTSGSLQSK 173.09 8.1406e-07 12095700.0 66091.0 77148.0 75543.0 81259.0 65110.0 34208.0 38199.2 45067.4 29095.6 76053.0 True False 62417.926803235336 83065.00353008164 70682.64562499934 70191.38402040637 56930.29970921475 38919.8414906938 39975.53849027881 45198.53867269031 34915.53299898858 73857.15228057513 0.8451168895074177 1.1246710841832475 0.9570182906116365 0.9503667803729704 0.770816338720221 0.5269610361206676 0.5412548041172258 0.6119723991115454 0.4727441002104758 1.0 16.172450016992855 -6.425282234506418 2.6191898865723644 0.601479441829171 0.9840481133924425 0.521693729335043 0.150817349964157 0.1966237405938193 2.637576868391048 0.048303057193921486 0.0548740405149248 3.755932385691367e-07 6.425282234506418 0.38256867156327146 RAQTTNSNSS(ph)SSSDVSTHS ddPTM_A459_Selumetinib_30min_R2 1 RAQTTNSNSSSSSDVSTHS 19 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RAQT(0.005)T(0.005)NS(0.005)NS(0.08)S(0.433)S(0.433)S(0.022)S(0.018)DVSTHS 58.36600000000001 0.023975 594990.0 853.26 636.49 929.26 936.37 1105.7 1039.6 0.0 1140.9 924.09 874.64 True False 805.8392250704118 685.3067363620809 869.4724233017884 808.8347906716529 966.7920809165827 1182.7954634508096 0.0 1144.219830113837 1108.933821231917 849.3868706123658 0.9487304936670868 0.8068252054190674 1.0236471193331984 0.9522572324299328 1.1382234813914343 1.3925285454413403 0.0 1.3471126876365669 1.3055697699123023 1.0 9.730277998190644 -1.5228809006114907 0.261025231921685 1.0416108770974835 7.885091101101197e-09 0.014121173376946738 0.3753562570172982 373.6673597151446 5.163158192536514 0.46798666835272396 173.35626995714247 0.02999985111536793 1.5228809006114907 -1.0416108692123924 RAS(ph)AAAAAGGGATGHPGGGQGAENPAGLK ddPTM_A459_Selumetinib_30min_R2 1 RASAAAAAGGGATGHPGGGQGAENPAGLK 29 1 Q07617 Q07617 SPAG1 Sperm-associated antigen 1 1 RAS(0.998)AAAAAGGGAT(0.002)GHPGGGQGAENPAGLK 62.557 0.00092617 4911900.0 17077.0 9396.5 14472.0 16079.0 12719.0 8165.3 12069.0 10230.0 10064.0 11140.0 True False 16127.92870464738 10117.1813354904 13540.88727592221 13889.012462177898 11121.125510697311 9289.995957786545 12630.232414269805 10259.76760633233 12077.081211654708 10818.359254803981 1.4907924875470964 0.9351862974043669 1.2516581264307032 1.2838372377040785 1.0279863377396055 0.8587250375939628 1.167481326584828 0.9483663247526557 1.1163505414457169 1.0 13.401194091796526 -6.278193416554515 20.385026076620253 1.0165648229195028 1.2193761272154253 0.340747135037871 0.1491074540224097 90.02390897286911 109533.12727434606 0.04426929950994899 0.05046056093450945 5.269951076251998e-07 6.278193416554515 0.20281130429592253 RAS(ph)AILR ddPTM_A459_Selumetinib_30min_R2 2 RASAILR 7 1 P46779 P46779 RPL28 60S ribosomal protein L28 1 RAS(1)AILR;RAS(1)AILR 80.755 0.022743 13974600.0 49346.0 46814.0 58674.0 55843.0 48488.0 27591.5 32083.1 38507.0 33653.8 43688.0 True False 46603.546867689256 50404.48326926495 54898.978719420964 48237.087065451844 42396.5039517801 31391.978674300717 33575.02772145658 38619.04899482299 40385.50036573785 42426.613924944024 1.0984507731428803 1.1880392660709242 1.2939750227661704 1.1369534969438522 0.9992903045900106 0.7399124221847062 0.7913671305669929 0.9102552719183078 0.9518907268249814 1.0 15.372681921043396 -6.369776892938369 2.9058797905958467 0.8680526808289425 1.192375269625927 0.7333192220593747 0.08494274103436943 0.13636422638661794 2.2220849544270327 0.02921623960125955 0.034055351978121574 4.2679871880849935e-07 6.369776892938369 0.3243225887969846 RAS(ph)EELDGLFR ddPTM_A459_Selumetinib_30min_R1 1 RASEELDGLFR 11 1 Q14814-4;Q14814;Q05BX2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 RAS(1)EELDGLFR 102.9 0.024817 2204300.0 1134.2 1438.5 1029.3 1143.0 1329.1 1135.4 1256.7 1133.7 768.2 1117.3 True False 1160.6246532309788 1270.0797512594932 889.5267135401886 943.3965067673032 1208.883139671664 1123.9789068607172 1161.906107225025 1103.630593223407 1303.5792928918972 1260.7163384236221 0.9206072911549665 1.0074270575786928 0.7055724483212753 0.7483019597786048 0.9588859149578647 0.8915398909370216 0.9216237402601224 0.875399611782114 1.0339988886967788 1.0 10.30002798999886 -8.045522801828081 0.9735206943624479 1.0157332914762356 0.86566434872263 0.25083745477413044 0.08866873813354886 0.8284017186792638 1.4943116047034581 0.08808137042458883 0.03248882791006338 9.004864831331082e-09 8.045522801828081 -0.1500689427536056 RAS(ph)FAEK ddPTM_A459_Selumetinib_30min_R1 1 RASFAEK 7 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 RAS(1)FAEK 77.533 0.025828 108450000.0 5497.7 6346.5 5851.0 6103.3 6155.1 6880.9 5603.1 6312.8 5583.1 5069.2 True False 5625.785713337991 5603.448829592195 5056.466337242439 5037.473228130257 5598.372291771164 6811.6843933573255 5180.453655918311 6145.364037135686 9474.112926509699 5719.8811981894105 0.9835493987390499 0.9796442680253443 0.8840159720175708 0.8806954294303936 0.9787567429797827 1.1908786489330438 0.9056925268934166 1.0743866566810791 1.6563478502855382 1.0 12.481769467231677 -8.017856774590019 23.993207012833132 1.3405718452775153 0.9751345855413177 0.40992121073331256 0.1686407393876962 383.50683864758616 515293.46739183855 0.10216240859601268 0.040437746971865085 9.597170831754072e-09 8.017856774590019 -0.36543725973619756 RAS(ph)FAEK ddPTM_A459_Selumetinib_30min_R2 1 RASFAEK 7 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 RAS(1)FAEK 63.426 0.044422 12188000.0 37999.0 32724.0 30793.0 35199.0 36918.0 30748.0 49577.0 63285.0 39553.0 57005.0 True False 35887.167702049264 35233.82557575567 28811.811904883416 30404.83547833819 32280.030788892473 34983.257897446616 51882.42873496182 63469.14887260423 47464.7052031577 55359.117533222765 0.648261195285713 0.636459306899369 0.5204528754923258 0.5492290490376998 0.583102336657014 0.6319330844905909 0.9371975393904269 1.1464985661036662 0.8573963480301617 1.0 15.756533325042321 -7.2773461791653276 3.4685788154417243 1.008187258824917 0.5861889430950619 0.8709574662077955 0.07399637881369361 0.07683868811725186 1.9762949279364752 0.03150458239133435 0.021550388905263382 5.2802419221054393e-08 7.2773461791653276 -0.42199831572985513 RAS(ph)GDVQTMK ddPTM_A459_Selumetinib_30min_R2 1 RASGDVQTMK 10 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 RAS(1)GDVQTMK 93.228 0.013099 4897900.0 40743.0 39412.0 47143.0 56335.0 57056.0 32835.0 38607.0 37654.0 34562.0 44927.0 True False 38478.66716715163 42434.77367044619 44109.870705417445 48662.07581670446 49888.11519288824 37357.72320354686 40402.301998319206 37763.56690604473 41475.36574296605 43629.84077563543 0.881934622796964 0.9726089510311345 1.011002330543688 1.115339294198828 1.143440230493522 0.8562424831128158 0.92602451166591 0.8655444584416946 0.9506192322876292 1.0 15.413027588248498 -6.782401123568322 24.99988013476707 0.9116788187915349 1.0262182153599773 0.3117428162450945 0.07767316531448733 302.4118373677541 360666.9026971218 0.02926311509850107 0.02583317336167466 1.650436715782669e-07 6.782401123568322 0.11453939656844236 RAS(ph)GLSTEGATGPSADTSGSELDGR ddPTM_A459_Selumetinib_30min_R1 2 RASGLSTEGATGPSADTSGSELDGR 25 1 Q7Z628 Q7Z628 NET1 Neuroepithelial cell-transforming gene 1 protein 1 RAS(0.577)GLS(0.211)T(0.211)EGATGPSADTSGSELDGR;RAS(0.333)GLS(0.333)T(0.333)EGATGPSADTSGSELDGR 128.68 3.3498e-08 7022200.0 577.7 499.05999999999995 635.07 810.48 621.54 529.18 724.47 490.74 244.294 416.66999999999996 True False 591.1592859914801 440.62982319330064 548.8309821898066 668.9448825938442 565.3218167417998 523.8569296569971 669.822644625857 477.7239810518259 414.5490754721863 470.153653209497 1.2573746517887077 0.9372038698101092 1.167343863954305 1.4228218328780429 1.202419279064703 1.1142249476971953 1.4246888013170218 1.0161018164820164 0.8817310524809775 1.0 8.876988517833324 -7.9824394615856615 24.233553532865596 0.9435491003539596 1.209394223222983 0.42332744938968836 0.1364459814784173 155.28266365718707 214289.95298221032 0.0768358506403062 0.036896792258303175 1.0412632442416236e-08 7.9824394615856615 0.2658451228690235 RAS(ph)GQAFELILS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 RASGQAFELILSPR 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 2 RAS(1)GQAFELILS(1)PR;RAS(1)GQAFELILS(1)PR 139.16 0.0014030999999999998 17300100.0 13442.8 16106.5 16151.3 17385.3 15531.599999999999 13420.4 16608.7 14913.8 10122.9 12728.8 True False 13755.99108486458 14220.74349229129 13958.042172740355 14349.28371749921 14126.769522326696 13285.402960748246 15355.89238725892 14518.237577150252 17177.821952636532 14362.665469011543 0.9577603206413249 0.9901186881344233 0.9718281194292111 0.999068296094398 0.9835757542920004 0.9249956416107048 1.069153383847193 1.0108317017112434 1.1960051558465166 1.0 13.810035893478958 -7.2824432958659555 23.70837947640935 1.0699002351059823 0.973937790916683 0.45050964680799566 0.052844956459369916 392.1333498967046 442621.6452212236 0.02096185816456501 0.014153154348671603 5.218632374353527e-08 7.2824432958659555 -0.09596244418929933 RAS(ph)GQAFELILSPR ddPTM_A459_Selumetinib_30min_R1 3 RASGQAFELILSPR 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 RAS(1)GQAFELILSPR;RAS(1)GQAFELILSPR;RAS(1)GQAFELILSPR 177.41 3.6122e-05 835880000.0 5738.5 6297.6 7061.799999999999 6914.9 6235.0 5492.4 5302.7 4976.3 3069.62 4741.0 True False 5872.195884822761 5560.274064325191 6102.8463476907655 5707.342523749107 5671.045350878657 5437.151442700198 4902.713069771737 4844.312358699518 5208.920943825598 5349.553531250689 1.0976983126758024 1.0393903027315323 1.1408141468329156 1.0668820286418874 1.0600969441187749 1.016374807904582 0.9164714477818331 0.9055545159797571 0.9737113412168787 1.0 12.385202775217264 -6.937632038056743 2.2990196851206317 0.9414213862842162 1.083674913052188 0.7503883904853733 0.035734477489119836 0.1404694067180997 1.5051442168573475 0.01452613366012592 0.011964285832254859 1.154430951002649e-07 6.937632038056743 0.14225352676797187 RAS(ph)GQAFELILSPR ddPTM_A459_Selumetinib_30min_R2 7 RASGQAFELILSPR 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 RAS(1)GQAFELILSPR;RAS(1)GQAFELILSPR;RAS(0.999)GQAFELILS(0.001)PR;RAS(1)GQAFELILSPR;RAS(1)GQAFELILSPR;RAS(1)GQAFELILSPR;RAS(1)GQAFELILSPR 223.93 1.4933e-09 164969590.0 104229.6 119182.0 118428.0 129442.9 120971.8 103179.0 100886.3 97595.9 95284.9 119319.0 True False 98436.93609614778 128322.87616946944 110808.47141465703 111812.55371854274 105774.24098238652 117390.97068429308 105577.71285241099 97879.88791112897 114344.54248255173 115873.9504420068 0.8495173912743573 1.107435067847222 0.9562845746776799 0.9649498726161345 0.9128388268364507 1.0130919869090467 0.9111427758325291 0.8447100279032639 0.9868011062570917 1.0 16.822196745766846 -5.810114190716214 2.774828805425909 0.9391962337871952 0.9865497974872752 0.011355721458873869 0.07489607432422904 0.7865902331459129 12.322519639343144 0.02136568272877312 0.036623081744821075 1.5484094361434122e-06 5.810114190716214 0.04735356370008004 RAS(ph)ISEPSDTDPEPR ddPTM_A459_Selumetinib_30min_R1 3 RASISEPSDTDPEPR 15 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 RAS(0.998)IS(0.002)EPSDTDPEPR;RAS(0.996)IS(0.004)EPSDTDPEPR;RAS(0.996)IS(0.004)EPSDTDPEPR 249.86 9.2973e-28 99876000.0 3015.0499999999997 3332.0 3093.4900000000002 3795.74 3475.4 2598.45 2953.26 2863.61 1533.3500000000001 2307.67 True False 3085.294798733965 2941.8878909952264 2673.41104932424 3132.885263864328 3161.050683631706 2572.311952203832 2730.4932205167343 2787.6577604837985 2601.9829585469834 2603.8819231093194 1.1848827596029339 1.1298084851260426 1.0267021041153415 1.2031594966193093 1.213976200524894 0.9878758054943638 1.048624054832804 1.0705776386185095 0.9992707178672416 1.0 11.346448313500915 -6.769787481491156 24.99998850354203 1.0273903895983147 1.146403182196213 0.5903254594897169 0.05412041025194506 154.95446330242575 464037.7544796783 0.02005801398206407 0.017982787285619504 1.6990748776830762e-07 6.769787481491156 0.11901279259789832 RAS(ph)ISEPSDTDPEPR ddPTM_A459_Selumetinib_30min_R2 1 RASISEPSDTDPEPR 15 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 RAS(0.996)IS(0.004)EPSDTDPEPR 111.09 0.0017141 57096000.0 22635.0 20459.0 27068.0 26728.0 25317.0 20777.0 21385.0 27711.0 19722.0 25014.0 True False 21377.03731508423 22028.13951394649 25326.47434941008 23087.600291628245 22136.452123148345 23638.84315517265 22379.444873573597 27791.634422196992 23666.95107872162 24291.78082582288 0.8800111226246455 0.9068145177125067 1.0425943874187804 0.9504284785529369 0.9112733348728654 0.9731210455366806 0.9212764199561518 1.1440756287679685 0.9742781415828909 1.0 14.568180637098678 -7.726243353110327 24.999880565488667 1.0443829865247185 0.9438764930704976 0.3705144929077172 0.058730487665198304 174.66354718671394 124064.24092025268 0.027112956336661335 0.01565277920027744 1.878264053060965e-08 7.726243353110327 -0.10050649345422091 RAS(ph)LSDLTDLEDIEGLTVR ddPTM_A459_Selumetinib_30min_R1 10 RASLSDLTDLEDIEGLTVR 19 1 J3KSI3;J3KSU7;K7EN88;Q8WZ73-3;Q8WZ73-2;Q8WZ73 J3KSI3 RFFL;hCG_2039718 E3 ubiquitin-protein ligase rififylin 1 RAS(0.967)LS(0.033)DLTDLEDIEGLTVR;RAS(0.795)LS(0.205)DLTDLEDIEGLTVR;RAS(0.997)LS(0.003)DLTDLEDIEGLTVR;RAS(0.983)LS(0.017)DLTDLEDIEGLTVR;RAS(0.995)LS(0.005)DLTDLEDIEGLTVR;RAS(1)LSDLTDLEDIEGLTVR;RAS(0.953)LS(0.047)DLTDLEDIEGLTVR;RAS(0.993)LS(0.007)DLTDLEDIEGLTVR;RAS(0.995)LS(0.004)DLT(0.001)DLEDIEGLTVR;RAS(0.865)LS(0.132)DLT(0.002)DLEDIEGLTVR 243.09 7.8449e-30 86174100.0 8432.060000000001 8128.78 11488.07 9943.529999999999 9973.720000000001 8433.22 9560.74 10084.94 4808.7699999999995 7482.379999999999 True False 8628.510592067365 7177.058658632705 9928.053193451511 8207.079148675319 9071.598787003288 8348.389463551111 8839.565684404064 9817.454630698128 8160.13147133529 8442.816357553158 1.0219943472237294 0.8500787361331064 1.1759172263138973 0.9720783682962685 1.0744754360181725 0.9888157114873676 1.0469925330658132 1.1628175024694436 0.9665177028320685 1.0 13.043508618583562 -5.248829291530159 24.955798851492688 1.0502865392522887 0.9360365598214232 0.24196200266569123 0.07953670851719603 987.2862228276739 1953866.2810044384 0.01883618579042328 0.04906075872524339 5.638592488658071e-06 5.248829291530159 -0.11424997943086546 RAS(ph)LSDLTDLEDIEGLTVR ddPTM_A459_Selumetinib_30min_R2 2 RASLSDLTDLEDIEGLTVR 19 1 J3KSI3;J3KSU7;K7EN88;Q8WZ73-3;Q8WZ73-2;Q8WZ73 J3KSI3 RFFL;hCG_2039718 E3 ubiquitin-protein ligase rififylin 1 RAS(1)LSDLTDLEDIEGLTVR;RAS(0.997)LS(0.003)DLT(0.001)DLEDIEGLTVR 105.89 0.0015175 8639000.0 20313.8 10873.7 18254.4 20516.6 18418.7 14505.2 19764.4 16694.7 12984.8 15386.8 True False 19184.84031858441 11707.677825543777 17079.93177788795 17722.2036868909 16104.778240732801 16503.159634904478 20683.48376241563 16743.278813043642 15582.122825625403 14942.543104292452 1.2839073097987785 0.7835130702872515 1.143040489070532 1.1860232601102523 1.0777802766455786 1.1044411596954815 1.3842010438286114 1.120510658472446 1.0428026017304393 1.0 13.867138084016783 -5.448824044195956 24.999959224400044 1.1447472532666632 1.0161017222999382 0.05798688659102147 0.14929842450391312 288.31345247236044 97329.15311717772 0.03742460777359963 0.07790550571177729 3.5577543293201106e-06 5.448824044195956 -0.12864553096672493 RAS(ph)LSEIGFGK ddPTM_A459_Selumetinib_30min_R2 2 RASLSEIGFGK 11 1 Q00537-2;F5H6Z0;Q00537 Q00537-2 CDK17 Cyclin-dependent kinase 17 1 RAS(0.992)LS(0.008)EIGFGK;RAS(0.997)LS(0.003)EIGFGK 95.822 0.0107 33990000.0 130426.0 116683.0 143794.0 156929.0 149831.0 134649.0 133165.0 136077.0 118713.0 147212.0 True False 123177.4450566458 125632.2109050205 134542.45059106973 135554.99948237522 131007.89027386512 153195.67752807614 139357.43636144174 136472.96154124005 142458.91711835907 142961.60705728916 0.8616120620922005 0.8787828668900999 0.9411089687677783 0.9481916318138066 0.916385125842676 1.0715861459691471 0.974789240481865 0.954612670844915 0.9964837416892729 1.0 17.12526823161597 -5.299116584933113 0.72565871685532 0.991432124389286 0.8240782999325869 0.6171916119896437 0.036069880307725045 1.14126701651192 0.7300798428435415 0.016987237278821427 0.1395318760281103 5.02207755396065e-06 5.299116584933113 -0.1673538244566991 RAS(ph)LTLEEK ddPTM_A459_Selumetinib_30min_R1 2 RASLTLEEK 9 1 A0A0U1RQQ9;Q6P3W7 A0A0U1RQQ9 SCYL2 SCY1-like protein 2 1 RAS(0.987)LT(0.013)LEEK;RAS(0.947)LT(0.053)LEEK 85.67200000000003 0.017896000000000002 27254000.0 15584.0 16014.4 17497.9 18619.1 15764.7 15744.4 13932.0 13896.0 8626.0 11216.0 True False 15947.076878814643 14139.426603107428 15121.7812890847 15367.623708793615 14338.78566848384 15586.025630771424 12881.098023282446 13527.432939430588 14637.691981886897 12655.682853091697 1.2600724167893382 1.1172393277580641 1.1948609541357582 1.214286410870308 1.1329918610421699 1.2315436323504159 1.0178113795049535 1.0688821058854148 1.1566102083785237 1.0 13.627497731501492 -7.26024479689222 24.999964314038255 1.0665660978078875 1.1869255627359871 0.5702057471051668 0.055533068148049806 84.9676331599357 1778213.5747935222 0.021214721430554518 0.015512954831212636 5.492312038134974e-08 7.26024479689222 0.12035946492809968 RAS(ph)LTLEEK ddPTM_A459_Selumetinib_30min_R2 1 RASLTLEEK 9 1 A0A0U1RQQ9;Q6P3W7 A0A0U1RQQ9 SCYL2 SCY1-like protein 2 1 RAS(0.987)LT(0.013)LEEK 80.17 0.024173 6811600.0 26458.0 21501.0 25742.0 30623.0 28913.0 24589.0 23846.0 25446.0 22586.0 26046.0 True False 24987.57027976578 23150.057563388425 24085.78774577042 26452.09457237847 25280.690454500473 27975.911553281992 24954.886249952575 25520.04364718793 27103.831105567715 25293.98430436487 0.987885893305223 0.9152396587592381 0.9522338377356407 1.045785996151415 0.9994744264207477 1.1060302408922709 0.98659372717513 1.0089372769470744 1.07155246004049 1.0 14.62650668754317 -5.753220413119756 23.68730154640348 1.0315065866736635 0.9481317135120204 0.47509608470869746 0.038191258209758196 76.71301824220443 221084.12385095505 0.010063777201936238 0.01702287369062502 1.765141748641711e-06 5.753220413119756 -0.08337487316164305 RAS(ph)PAPSDSSPGEPFVGGPVSSPR ddPTM_A459_Selumetinib_30min_R1 2 RASPAPSDSSPGEPFVGGPVSSPR 24 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 RAS(0.986)PAPS(0.013)DSSPGEPFVGGPVSSPR;RAS(0.843)PAPS(0.104)DS(0.026)S(0.026)PGEPFVGGPVSSPR 78.268 0.0001665 14217600.0 1988.6799999999998 1765.27 2706.8 2341.5 2179.59 1834.3 1942.1799999999998 2065.3 1269.0700000000002 1679.13 True False 2035.0123747023306 1558.5913677482413 2339.2314273881107 1932.6009803986358 1982.4464693378682 1815.8486074111438 1795.679798941911 2010.5215349601328 2153.519100794482 1894.662691611258 1.074076342830035 0.8226220818349386 1.234642682175149 1.020023769378767 1.0463321403410109 0.9584020498482032 0.9477569843394288 1.0611501159873191 1.1366240071804483 1.0 10.887725311710184 -7.982530308926408 24.648561055192378 1.0785037222381912 1.0143749179506207 0.04723872335089674 0.10344862725170892 563.656977453383 795281.2806269792 0.05545997798901279 0.02663306494662611 1.0410454516897599e-08 7.982530308926408 -0.0641288042875705 RAS(ph)PAPSDSSPGEPFVGGPVSSPR ddPTM_A459_Selumetinib_30min_R2 2 RASPAPSDSSPGEPFVGGPVSSPR 24 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 RAS(0.933)PAPS(0.065)DS(0.001)SPGEPFVGGPVSSPR;RAS(0.456)PAPS(0.266)DS(0.012)S(0.266)PGEPFVGGPVSSPR 86.191 5.064e-05 8836100.0 27490.0 26246.0 28470.0 29101.0 32171.0 22301.0 27411.0 25886.0 22451.6 28023.0 True False 25962.21585118911 28258.983805808686 26638.27119579226 25137.393597974926 28129.39136761093 25372.76032167804 28685.665813866064 25961.323974341998 26942.54735011794 27213.903177501994 0.9540055934590204 1.0384024526540783 0.9788478713268292 0.9236967381715483 1.0336404588543469 0.9323455057580258 1.0540812770136108 0.9539728206207658 0.9900287795685117 1.0 14.732056270756086 -7.232160240189919 24.991807673362622 0.9956851876054273 0.9798819851909343 0.05989405317980934 0.04195523131642163 3148.7484541665194 2687683.1335201305 0.015491965588249066 0.01199790908277533 5.859219389582456e-08 7.232160240189919 -0.015803202414493067 RAS(ph)PNLFSEAQYQEAPVEK ddPTM_A459_Selumetinib_30min_R1 3 RASPNLFSEAQYQEAPVEK 19 1 F6VUX8;Q9HC77-2;Q9HC77 F6VUX8 CENPJ Centromere protein J 1 RAS(0.995)PNLFS(0.004)EAQY(0.001)QEAPVEK;RAS(0.997)PNLFS(0.003)EAQYQEAPVEK;RAS(0.848)PNLFS(0.151)EAQY(0.001)QEAPVEK 108.77 0.00037208 21272000.0 9028.400000000001 9476.6 11403.9 11212.099999999999 9425.4 9284.6 9077.7 8023.1 5096.9 7327.7 True False 9238.74415379172 8367.075266448184 9855.313017138797 9254.117212183455 8572.874234189521 9191.205353742305 8392.9617805018 7810.301325298335 8649.06703715271 8268.281672842366 1.1173717247849566 1.0119485036329026 1.191942099591155 1.1192310057093389 1.0368386774180187 1.1116221867393965 1.0150793251358325 0.9446099727046923 1.0460537484542956 1.0 13.013371822081828 -7.35105656514417 4.588081326926796 0.9939128464715379 1.096647738664205 0.4612013189452048 0.05129975759400823 0.20791504715188305 7.593910130880387 0.022196520996465845 0.014688085372518379 4.455982072079381e-08 7.35105656514417 0.10273489219266718 RAS(ph)PNLFSEAQYQEAPVEK ddPTM_A459_Selumetinib_30min_R2 1 RASPNLFSEAQYQEAPVEK 19 1 F6VUX8;Q9HC77-2;Q9HC77 F6VUX8 CENPJ Centromere protein J 1 RAS(0.793)PNLFS(0.206)EAQY(0.001)QEAPVEK 60.521 0.019965 9067400.0 62403.0 58474.0 62227.0 69186.0 64563.0 47769.0 51605.0 52019.0 44840.0 68615.0 True False 58934.89107900156 62958.76777645571 58223.38256763486 59762.74744749299 56452.0187394568 54348.74614619251 54004.73475336757 52170.36667779099 53809.25293428036 66633.90666681992 0.8844579888387055 0.944845813877603 0.8737801140605636 0.8968819394954011 0.8471965934959483 0.8156319937527428 0.8104692859057445 0.7829402369975256 0.80753561701455 1.0 16.023968859132154 -6.2909494835627005 2.199913393659591 0.827428060138041 0.9045969834345153 0.14915786360477334 0.05964894840357643 0.4383111563436468 4.165619059159619 0.019173013653289103 0.024136657316381503 5.117413570120665e-07 6.2909494835627005 0.07716892329647429 RAS(ph)PPDPSPSPSAASASER ddPTM_A459_Selumetinib_30min_R1 1 RASPPDPSPSPSAASASER 19 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 RAS(0.999)PPDPSPSPSAASASER 112.91 0.00099204 8211400.0 1194.8 1175.3 1672.5 1674.4 1585.6 1116.8 1521.0 1386.2 625.46 1142.5 True False 1222.636515323905 1037.6953296178535 1445.3836863848883 1381.997472380729 1442.1827599604171 1105.566005973268 1406.2697454358754 1349.4334729878165 1061.3599382090163 1289.151003892409 0.9484044240219548 0.8049447477329492 1.1211903663890086 1.0720214064977518 1.1187073939406247 0.8575923244330321 1.0908495135091567 1.0467613715642257 0.8233014867958758 1.0 10.3322055474363 -5.25438103927883 24.999692320804385 1.0206144146601503 0.8766745883142333 0.22951091431553694 0.1020886709790388 772.7726987856777 2737039.929668382 0.025809218961655785 0.06525763410362528 5.566971022776603e-06 5.25438103927883 -0.14393982634591707 RAS(ph)PPDPSPSPSAASASER ddPTM_A459_Selumetinib_30min_R2 4 RASPPDPSPSPSAASASER 19 1 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 RAS(1)PPDPSPSPSAASASER;RAS(0.827)PPDPS(0.165)PS(0.007)PSAASASER;RAS(0.765)PPDPS(0.054)PS(0.097)PS(0.032)AAS(0.032)AS(0.019)ER;RAS(0.997)PPDPS(0.002)PSPSAASASER 108.25 0.0003832 29921800.0 70024.0 73988.1 87763.0 93715.0 97822.0 67462.8 67438.7 72458.7 68139.8 81055.0 True False 66132.34640828181 79662.74936076187 82116.42412912963 80950.85533260787 85532.72582022424 76755.18833367567 70574.73317724896 72669.54282081638 81769.66398508644 78714.73154381834 0.8401520923877857 1.0120437153039872 1.0432154505083673 1.028407945310018 1.0866164965907368 0.975105762648103 0.8965886282412324 0.9232013041975914 1.0388101741739093 1.0 16.264346042427256 -9.976621512070013 15.97813447292184 0.999995368914613 0.9852236473779431 0.004060183820633334 0.07207658422703365 0.0 0.0 0.07331062110039577 0.017780437310386272 1.0553061957999614e-10 9.976621512070013 -0.014771721536669946 RAS(ph)PSKPASAPASR ddPTM_A459_Selumetinib_30min_R1 1 RASPSKPASAPASR 14 2 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 RAS(0.988)PS(0.012)KPASAPASR 173.51 0.0033624 29508000.0 1785.9 2393.9 2395.4 2512.6 2403.3 2038.8 1676.5 1884.8 969.17 1902.6 True False 1827.5079952435235 2113.6210751060835 2070.117836990352 2073.8215773434185 2185.9219393370763 2018.2915230822878 1550.0402552421058 1834.8089813067636 1644.6107046238476 2146.817242893389 0.8512638890399846 0.9845370313205771 0.9642729691328243 0.9659981930033364 1.0182151958081833 0.9401319696697239 0.7220177965186396 0.8546647309548744 0.7660692637289009 1.0 11.067983665428502 -7.090208006564748 8.390906435989594 0.8239329032878341 0.9612694297446068 0.3502685744629196 0.07848761101453451 0.3181321634210623 27.055651387863882 0.028176175386913974 0.02183190691177964 8.124413019151445e-08 7.090208006564748 0.13733652645677275 RAS(ph)PSPPPKR ddPTM_A459_Selumetinib_30min_R2 1 RASPSPPPKR 10 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RAS(0.985)PS(0.015)PPPKR 57.859 0.043957 544980.0 2379.4 2164.6 2468.9 2089.5 1137.4 2208.0 2008.2 2287.8 2219.8 3149.9 True False 2247.162473492882 2330.6178597139938 2310.0536619350733 1804.9064954114506 994.5096435149879 2512.1319577716295 2101.5852791728075 2294.4571192343215 2663.8220263941917 3058.954202576938 0.7346178872504261 0.7619002133966649 0.7551775897752989 0.5900403784701821 0.3251142637824354 0.8212388258887132 0.6870273760236033 0.7500789378609901 0.870827691421507 1.0 11.57882279227421 -8.328446068610106 1.1511633646423785 0.9987841080308326 0.657838665592862 0.42063211257647504 0.1292854110160107 0.486061608989598 1.3397076532514813 0.13070644666554512 0.04246172803194739 4.694117230035167e-09 8.328446068610106 -0.34094544243797065 RAS(ph)QEANLLTLAQK ddPTM_A459_Selumetinib_30min_R1 2 RASQEANLLTLAQK 14 1 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2;H7C1L3 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 RAS(1)QEANLLTLAQK;RAS(1)QEANLLTLAQK 178.0 0.00012754 107968000.0 10793.400000000001 13098.8 12711.900000000001 12854.9 11744.3 10580.3 11974.0 10426.9 5949.1 8365.0 True False 11044.865219699568 11565.186406533088 10985.6938014685 10610.03303135871 10682.030138624574 10473.871788143771 11070.791539677291 10150.344740655502 10095.188194927352 9438.729232000003 1.1701644308488375 1.225290621466689 1.1638954282345384 1.1240954974518869 1.1317233364857446 1.1096696950087663 1.172911232811312 1.0753931478660197 1.0695495068024374 1.0 13.204376922416584 -1.52287883471007 0.02548907376752933 0.2853808086911356 2.283048636697254 0.7795644148343385 0.02869085874659824 861.9275041206273 1.6951577919584093 45.38035874266924 96.22910363511744 0.02999999382241358 1.52287883471007 1.9976678280061184 RAS(ph)QEANLLTLAQK ddPTM_A459_Selumetinib_30min_R2 4 RASQEANLLTLAQK 14 1 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2;H7C1L3 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 RAS(1)QEANLLTLAQK;RAS(1)QEANLLTLAQK;RAS(1)QEANLLTLAQK;RAS(1)QEANLLTLAQK 98.882 0.0051761 94216600.0 422375.0 409694.0 489125.0 510829.0 531095.0 410511.0 426786.0 462836.0 418084.0 486519.0 True False 398901.0884010908 441116.21242615895 457655.2300190331 441253.20897082274 464374.0980504592 467055.1640021698 446632.39466041507 464182.77613337594 501712.4822429899 472471.9323418291 0.844285260341115 0.9336347457503897 0.9686400369872632 0.9339247027516125 0.98286070825153 0.9885352589881671 0.945309899038152 0.9824557700869815 1.061888438020495 1.0 18.84986910160334 -2.6395868088822056 0.43218204588993125 0.9982073668824025 1.1166962387116195e-21 0.6839410448022332 0.030120687751367038 19.653479837394958 0.6301349938685216 0.020718529314108353 14.846180590567409 0.0022930482390603386 2.6395868088822056 -0.9982073668824025 RAS(ph)SASVPAVGASAEGTR ddPTM_A459_Selumetinib_30min_R1 1 RASSASVPAVGASAEGTR 18 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 RAS(0.5)S(0.5)ASVPAVGASAEGTR 209.19 2.5265e-11 11310000.0 1413.7 1474.1 1535.1 1932.2 1726.1 1491.3 1627.1 1523.5 782.61 1091.5 True False 1446.6364594186525 1301.5116867095014 1326.641851700713 1594.7775418860758 1569.9745597677063 1476.2988759920624 1504.366537014274 1483.0918309745616 1328.032010427139 1231.6046571103416 1.1745948272173883 1.0567609331416297 1.0771653420127145 1.2948778105693677 1.2747390574596127 1.198679192603766 1.2214686980348883 1.2041947246726665 1.0782940798088898 1.0 10.26632351248166 -8.463321136353189 3.242511111439426 1.0012077649050448 1.1875344563054573 0.431052612354927 0.07098168828122256 0.2380036004931379 5.254671818507398 0.07710738951262651 0.020509021867440632 3.440953974671344e-09 8.463321136353189 0.18632669140041247 RAS(ph)SASVPAVGASAEGTR ddPTM_A459_Selumetinib_30min_R2 1 RASSASVPAVGASAEGTR 18 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 RAS(0.504)S(0.351)AS(0.144)VPAVGASAEGTR 59.547 0.026945 9231600.0 11206.0 7567.9 10982.0 8951.8 10366.0 8451.4 8057.2 7131.0 7294.5 12151.0 True False 10583.215381172246 8148.333595366135 10275.43007629752 7732.549397283666 9063.730406784205 9615.503635829333 8431.875765038914 7151.750029399401 8753.603825359238 11800.16905791053 0.8968698100200123 0.6905268522321467 0.8707866832983325 0.6552914080582568 0.7681017417888698 0.8148615150037487 0.7145555054049333 0.6060718278103864 0.7418202046428348 1.0 13.526519908396057 -4.74585010517341 24.247496282961517 0.7504911275999364 0.8968704013206882 0.11429062004140522 0.10773187997505482 1175.3068718919783 1827918.7829974699 0.025308336339088536 0.5851444152991642 1.795353178146388e-05 4.74585010517341 0.14637927372075177 RAS(ph)SDLSIASSEEDKLSQNACILESVSEK ddPTM_A459_Selumetinib_30min_R1 1 RASSDLSIASSEEDKLSQNACILESVSEK 29 2 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 RAS(0.344)S(0.344)DLS(0.192)IAS(0.059)S(0.059)EEDKLS(0.002)QNACILESVSEK 47.73 0.014191 17925000.0 2052.3 2174.0 2057.9 2038.0 1730.6 1856.1 1705.5 1700.2 1312.3 1673.3 True False 2100.114596919361 1919.467069334819 1778.4484832355538 1682.1015579980447 1574.0675355622463 1837.4293192039615 1576.852761894073 1655.105172972071 2226.8772534002037 1888.0843543222468 1.1122991364828216 1.0166214581147976 0.9419327474242811 0.8909038169546496 0.8336849632585823 0.9731712012748135 0.8351601231609725 0.8766055230441191 1.1794373743431454 1.0 10.88270750637656 -4.951492644475546 2.072874839783447 0.9280060282691287 1.1306950966706588 0.22950123216113716 0.09598172111186097 0.6667716661673727 4.2184365354906435 0.025805563167714735 0.22580924514631445 1.1181687625361619e-05 4.951492644475546 0.20268906840153011 RAS(ph)SLNFLNK ddPTM_A459_Selumetinib_30min_R2 1 RASSLNFLNK 10 1 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 RAS(0.603)S(0.397)LNFLNK 132.5 0.0043626 21047000.0 126580.0 122810.0 135190.0 135410.0 143140.0 101470.0 101970.0 106700.0 81295.0 117570.0 True False 119545.19033988794 132229.1321036106 126492.02258374276 116966.92440472115 125157.47351216395 115446.57144705037 106711.80704972179 107010.47933486415 97556.2715720858 114175.44861645454 1.0470306163759582 1.15812229078953 1.1078741018015426 1.0244490021461963 1.0961855199938906 1.0111330662239468 0.9346300657700493 0.9372459721558931 0.8544417626928102 1.0 16.80089293277986 -7.0433505522577775 1.7014456305107792 0.9203417133105343 1.092078836103477 0.7020714700693984 0.04736307348103308 0.1955865220805396 1.1344558253888937 0.022672427960523468 0.016586406278459507 9.050018098935655e-08 7.0433505522577775 0.17173712279294273 RAS(ph)SLNVLNVGGK ddPTM_A459_Selumetinib_30min_R2 2 RASSLNVLNVGGK 13 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 RAS(0.5)S(0.5)LNVLNVGGK;RAS(0.636)S(0.364)LNVLNVGGK 152.94 0.00021818 163550000.0 389890.0 439890.0 458350.0 485190.0 460420.0 301320.0 285966.0 301410.0 224586.0 431320.0 True False 368221.47465333284 473628.1485307156 428860.2600137465 419106.28500056465 402577.9233929753 342824.09488937823 299263.9856308789 302287.0531988884 269509.4754571434 418866.67089605605 0.8790899353859284 1.130737252303965 1.0238586400209684 1.000572053403046 0.9611123332676834 0.8184563697942246 0.7144612031095279 0.721678458093178 0.6434254481995384 1.0 18.676131568366884 -6.774701347761164 2.2302012134514912 0.7464468313850238 1.0174938858693943 0.5261212206183647 0.10449771493975783 0.20997723730862944 2.1453370592682073 0.0389375667584879 0.035598019532949526 1.6799588820019204e-07 6.774701347761164 0.2710470544843705 RAS(ph)VCAEAYNPDEEEDDAESR ddPTM_A459_Selumetinib_30min_R1 1 RASVCAEAYNPDEEEDDAESR 21 1 P31323 P31323 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit 1 RAS(0.999)VCAEAY(0.001)NPDEEEDDAESR 92.613 0.0023733 0.0 913.97 637.05 1065.0 853.45 831.48 643.94 842.35 935.93 273.47 638.36 True False 935.2637227239624 562.46388984349 920.3788496262523 704.4109787406436 756.2727808097172 637.4625482507396 778.8108613201242 911.1060960709032 464.05861654145684 720.2997241529613 1.2984368747659714 0.7808747816819189 1.277772042337757 0.9779414806371027 1.0499417887450375 0.8849962409750547 1.0812316528872328 1.2648985769671386 0.6442576624434613 1.0 9.492453541567707 -4.7201848271380635 24.008397981270907 1.0132039217837665 1.2984420876439358 0.18668280412457205 0.18635372887378612 9847.172506087565 5729980.25315553 0.0432419796948337 16.452903006887354 1.9046499641178847e-05 4.7201848271380635 0.28523816586016926 RAS(ph)VCAEAYNPDEEEDDAESR ddPTM_A459_Selumetinib_30min_R2 2 RASVCAEAYNPDEEEDDAESR 21 1 P31323 P31323 PRKAR2B cAMP-dependent protein kinase type II-beta regulatory subunit 1 RAS(1)VCAEAYNPDEEEDDAESR;RAS(0.999)VCAEAY(0.001)NPDEEEDDAESR 131.13 2.6006e-05 35966000.0 41289.0 33005.0 42729.0 44570.0 43567.0 38339.0 38478.0 38279.0 36756.0 33359.0 True False 38994.322672962764 35536.37737219826 39979.862659817634 38499.48911246149 38093.72396607828 43619.8492432095 40267.30324271053 38390.3855525704 44108.227048448 32395.838992909008 1.203683061935765 1.0969426468620451 1.23410486972011 1.1884084595212516 1.1758832353258843 1.3464645645620499 1.2429776321435748 1.1850406331804992 1.361539889678507 1.0 14.983520900998748 -5.2877875602660955 22.883937091737113 1.2265011732909947 1.1503128311878472 0.06196384895024676 0.09782009685511854 543.2974460651659 471864.7893169962 0.02414108830619421 0.050293052902918675 5.154807357678667e-06 5.2877875602660955 -0.07618834210314751 RAS(ph)WAS(ph)ENGETDAEGTQMTPAK ddPTM_A459_Selumetinib_30min_R2 2 RASWASENGETDAEGTQMTPAK 22 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 2 RAS(0.998)WAS(0.999)ENGET(0.001)DAEGT(0.002)QMT(0.001)PAK;RAS(0.995)WAS(0.987)ENGET(0.017)DAEGTQMTPAK 79.467 0.0031881 11615900.0 68467.0 57922.0 72133.0 74988.0 75877.0 54162.0 66659.0 74570.0 63390.0 75022.0 True False 64661.87823511697 62364.43115141543 67492.04131247212 64774.50503848478 66344.65291101343 61622.32386631664 69758.77558230274 74786.98635427187 76069.77126458577 72855.9199294349 0.8875308732323425 0.8559967564999376 0.9263769008454221 0.8890767572658828 0.9106281682431846 0.8458107992597084 0.9574894620762195 1.0265052781806518 1.0441124254317793 1.0 16.152758583216617 -7.549116817921847 3.4190189060736067 1.02577642233702 0.8878159471613845 0.8638180112008921 0.02454307008755972 0.0797513385050942 1.9624071032009167 0.012245499251219987 0.006894119111998847 2.8241202318287168e-08 7.549116817921847 -0.1379604751756356 RAS(ph)WASENGETDAEGTQMTPAK ddPTM_A459_Selumetinib_30min_R1 2 RASWASENGETDAEGTQMTPAK 22 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 RAS(0.745)WAS(0.254)ENGET(0.001)DAEGTQMTPAK;RAS(0.617)WAS(0.27)ENGET(0.1)DAEGT(0.013)QMTPAK 150.34 1.2341e-07 38835000.0 3625.7000000000003 4648.5 4407.299999999999 4520.3 4160.8 3601.8 4396.6 4892.6 2566.7 3246.3 True False 3710.1717556159083 4104.25145897098 3808.8128675659927 3730.914461540021 3784.4563746489025 3565.569162172742 4064.9609222770323 4762.8323545954345 4355.502435649093 3662.9942266397634 1.012879498589716 1.120463534755828 1.0398085915248618 1.0185422718950239 1.0331592518289503 0.9734028888829579 1.1097371906059519 1.3002565824310905 1.1890552280898896 1.0 11.83880771183339 -7.524124617429372 24.974870933000126 1.1877929433032537 1.037078404391099 0.3546608749416955 0.07737925640181187 37.99624364438832 761616.0292247128 0.0344755294759313 0.02010485717226663 2.991406152678592e-08 7.524124617429372 -0.1507145389121547 RAS(ph)WASENGETDAEGTQMTPAK ddPTM_A459_Selumetinib_30min_R2 1 RASWASENGETDAEGTQMTPAK 22 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 RAS(0.743)WAS(0.257)ENGETDAEGTQMTPAK 138.59 6.029900000000001e-06 35067000.0 43827.0 34494.0 40725.0 48169.0 44085.0 31963.0 36828.0 40487.0 37814.0 43637.0 True False 41391.27079338179 37139.57888430864 38104.7978380274 41608.2991038402 38546.64817509956 36365.61311877477 38540.57497329758 40604.81046701632 45377.85661143792 42377.086427457936 0.976737059642746 0.8764070873037725 0.8991839942383972 0.9818584195274076 0.9096106274574726 0.85814330772896 0.9094673141173171 0.9581784376923733 1.070811149065587 1.0 15.37099678035171 -8.049192901589526 3.9887371447652287 1.0338020869188431 0.9144413655984724 0.5824964881748076 0.039960216618962645 0.1582220716179894 5.112906318980579 0.028994107010362008 0.010601204687923504 8.929087902667858e-09 8.049192901589526 -0.11936072132037068 RAS(ph)YDYNQDR ddPTM_A459_Selumetinib_30min_R2 1 RASYDYNQDR 10 1 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 RAS(0.997)Y(0.003)DYNQDR 78.705 0.026628 7844700.0 10689.0 10899.0 12312.0 9766.5 12815.0 11052.0 10816.0 11516.0 9896.3 17114.0 True False 10094.948171457267 11734.91825419145 11519.85932429203 8436.285851847773 11205.065132446422 12574.312679933008 11318.965431497401 11549.509653423576 11875.83652572522 16619.87435248793 0.6074021955494563 0.7060774350820997 0.6931375701145149 0.5076022641882907 0.6741967414915546 0.7565828966721811 0.6810500002247609 0.6949215985916681 0.7145563362184778 1.0 14.02062185481488 -14.522878745275694 0.2161089916266036 2.654545019509749 0.6274779614716592 0.7436593827336169 0.05990917020435635 79.23855863286181 0.7898666384800531 56.825231482726586 0.12556589584135985 3.0000000000320765e-15 14.522878745275694 -2.0270670580380896 RASEDTTSGS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 3 RASEDTTSGSPPK 13 1 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 1 RASEDT(0.001)T(0.001)S(0.004)GS(0.993)PPK;RASEDTTS(0.003)GS(0.997)PPK;RASEDTTS(0.016)GS(0.984)PPK 130.47 0.0029123 20322400.0 5697.7 7010.2 8634.0 8780.8 6330.900000000001 6499.5 6321.2 6282.7 4313.7 5927.200000000001 True False 5830.445324205737 6189.442525046438 7461.550223167194 7247.398116030041 5758.271212811177 6434.120931073835 5844.386794772686 6116.062386914261 7320.033839817465 6688.013855817143 0.8717753057784854 0.9254530057025743 1.115660102390075 1.0836398177803346 0.8609837444942958 0.9620376198050973 0.8738598514848048 0.9144811178276184 1.0945003999132867 1.0 12.70736212097113 -8.258842815708293 24.97930022477794 1.047250199460328 0.9548435279789902 0.170156865228549 0.08469276751715044 435.6626074056762 4191243.325575236 0.06869107940047033 0.02322859035764464 5.510070864294054e-09 8.258842815708293 -0.09240667148133785 RASEDTTSGS(ph)PPKK ddPTM_A459_Selumetinib_30min_R1 1 RASEDTTSGSPPKK 14 2 H0YER7;G3V1C3;Q9BZZ5-1;Q9BZZ5-5;Q9BZZ5-2;Q9BZZ5-6;Q9BZZ5 H0YER7 API5 Apoptosis inhibitor 5 1 RASEDTT(0.003)S(0.059)GS(0.938)PPKK 75.445 0.017328 63872000.0 7326.9 9776.8 10495.0 10199.0 8365.8 9775.0 7280.1 8589.6 6024.4 8415.2 True False 7497.602514334384 8632.127710888988 9069.836644908462 8417.936108941143 7609.114867101952 9676.672374989876 6730.956195757866 8361.775905046996 10222.96679523294 9495.372890989407 0.7896059059933498 0.9090878062388059 0.9551848831039847 0.8865303348886179 0.8013497684037862 1.0190934559476343 0.7088669684731579 0.8806158537472358 1.0766261538747972 1.0 13.213008941952905 -8.249563706798346 21.541161298476826 1.0383130374999434 0.8710372152080176 0.391164605373849 0.08455973576403629 103.20316367841048 187205.11725930776 0.05685146512516347 0.020953274624395203 5.62906538395013e-09 8.249563706798346 -0.16727582229192584 RASGQAFELILS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 RASGQAFELILSPR 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 RASGQAFELILS(1)PR;RASGQAFELILS(1)PR 105.5 0.0029883 42092000.0 3300.1 3685.3 4200.2 4663.2 4307.8 3262.2 3267.5 3680.4 2711.2 2865.6000000000004 True False 3376.985909123217 3253.8233627505115 3629.835910047119 3848.859659105243 3918.1602506038626 3229.385229840613 3021.0298443206593 3582.783836375963 4600.708381786662 3233.427673307734 1.044398158957001 1.0063077611449749 1.1225969085412901 1.1903342359805853 1.2117667832649124 0.9987497962300219 0.934311866400959 1.1080451453892717 1.422857984350776 1.0 11.658848624589467 -8.02269819527831 24.843084720949495 1.2294365433869434 1.0749110287298778 0.15847068198697545 0.12473373242656939 1168.902833966848 1279351.0536271546 0.08286112142595127 0.03184716180002597 9.490777778049635e-09 8.02269819527831 -0.15452551465706565 RASGQAFELILS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 RASGQAFELILSPR 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 RASGQAFELILS(1)PR;RASGQAFELILS(1)PR 119.62 0.0011222 7326700.0 17336.1 18401.0 16392.1 19732.5 23706.0 15698.9 12564.900000000001 14625.2 14365.2 26075.0 True False 16372.628963906856 19812.297531459484 15337.450132369027 17044.899459538858 20727.840345671077 17861.280974574747 13149.19274687702 14667.75691066781 17238.641397224 25322.146999013832 0.6465734901761879 0.7824098617005529 0.6056931165025755 0.6731222064307054 0.8185656748015213 0.7053620285543067 0.5192763768170651 0.5792461796876482 0.6807732929555838 1.0 14.628112111863624 -8.589511135029534 20.65347291179328 1.000000000084816 0.6673498680773677 0.5817192674278752 0.08456033241845769 8723.950996454494 2704084.0915215034 0.08811570956508039 0.022751378414137068 2.5732907860694176e-09 8.589511135029534 -0.3326501320074482 RASIS(ph)EPSDTDPEPR ddPTM_A459_Selumetinib_30min_R2 1 RASISEPSDTDPEPR 15 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 RAS(0.184)IS(0.646)EPS(0.139)DT(0.03)DPEPR 152.94 0.00039004 27710000.0 10142.0 9852.6 11215.0 11071.0 11059.0 9136.3 5868.7 7289.6 7976.9 12589.0 True False 9578.348241642774 10608.262738897758 10493.439109968747 9563.110701459753 9669.669551285606 10394.74239392616 6141.606178608431 7310.811529141755 9572.502893208315 12225.52285984986 0.7834714597851077 0.8677144413787499 0.8583223171935254 0.782225088537211 0.7909411860855461 0.8502493114682064 0.5023593877345099 0.5979958168620642 0.7829933331232488 1.0 13.577608547073114 RASPAPSDSSPGEPFVGGPVS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 RASPAPSDSSPGEPFVGGPVSSPR 24 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 RASPAPSDSSPGEPFVGGPVS(0.714)S(0.286)PR;RASPAPSDSSPGEPFVGGPVS(0.613)S(0.387)PR 120.61 7.6848e-08 9967500.0 30797.0 37617.0 30923.0 35531.0 35444.0 21866.1 24507.8 21701.7 16115.5 28806.0 True False 29085.426030158997 40502.1029422809 28933.44784641673 30691.61650560624 30991.207846619654 24877.95679430717 25647.46126128441 21764.848354090173 19339.050304692137 27974.295933023663 1.0397196805165576 1.4478327904749215 1.0342869009353972 1.097136334694121 1.1078458568115213 0.8893148500991847 0.91682240449196 0.7780302462732142 0.691314996845457 1.0 14.771814200948883 -6.655861951230484 0.9313380337778212 0.8068133832167178 1.2057404577064599 0.5460530085242643 0.13273159112266864 0.3909933923760888 0.7387232223581521 0.07385003644700344 0.07602809967724962 2.208706700922055e-07 6.655861951230484 0.3989270744897421 RASS(ph)ASVPAVGASAEGTR ddPTM_A459_Selumetinib_30min_R1 1 RASSASVPAVGASAEGTR 18 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 RAS(0.099)S(0.9)AS(0.001)VPAVGASAEGTR 260.98 2.0844e-42 11245000.0 1552.7 1883.3 2035.1 2282.8 2200.2 1859.9 1896.3 1432.9 1155.9 1434.1 True False 1588.874888971734 1662.8023604775833 1758.7445980041186 1884.1518334631667 2001.1922984768592 1841.1910946540847 1753.2605642801107 1394.8948372848376 1961.4778764042485 1618.1807043169401 0.9818896522081713 1.0275751997546396 1.0868653873527139 1.1643642940721488 1.2366927211146015 1.1378155046233114 1.0834763754151857 0.8620142568525095 1.2121500838388872 1.0 10.660157009033782 -10.25127531587075 8.1690520998054 0.9999976834101242 1.087568651908283 0.05875987464726995 0.10575449389168215 0.0 0.0 0.10691567774079881 0.0259308607270478 5.6069241898979923e-11 10.25127531587075 0.08757096849815882 RASS(ph)ASVPAVGASAEGTR ddPTM_A459_Selumetinib_30min_R2 1 RASSASVPAVGASAEGTR 18 1 A0A2R8YFI4;V9GYZ0;Q9BZ23-3;Q9BZ23-4;Q9BZ23 A0A2R8YFI4 PANK2 Pantothenate kinase 2, mitochondrial 1 RAS(0.269)S(0.704)AS(0.028)VPAVGASAEGTR 75.225 0.008015399999999999 9116400.0 7216.0 9240.2 10038.0 9197.8 11877.0 5637.3 5352.0 6871.1 5195.4 11512.0 True False 6814.963607936722 9948.893628074125 9392.166008548042 7945.043772909996 10384.905078272823 6413.786904685693 5600.878604786808 6891.09376342816 6234.625171604824 11179.618648231914 0.6095881999530035 0.8899135060968801 0.840115061530604 0.7106721635953589 0.9289140716723127 0.5737035498701962 0.5009901304346014 0.6163979273584618 0.557677803490269 1.0 13.448583356309431 -6.779597107020856 24.95942588723579 0.6164809841302774 0.7987950087700695 0.1682232791515279 0.15369402090019854 329.23794817337495 452564.13342543616 0.05090719090988059 0.0449833046585669 1.6611272128807775e-07 6.779597107020856 0.18231402463979207 RASS(ph)LNFLNK ddPTM_A459_Selumetinib_30min_R1 2 RASSLNFLNK 10 1 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 RAS(0.419)S(0.581)LNFLNK;RAS(0.002)S(0.998)LNFLNK 179.67 0.00020162 119255000.0 12557.0 14064.099999999999 16660.4 17671.6 16305.6 13554.5 14125.9 13542.900000000001 7713.2 11851.400000000001 True False 12849.553668331338 12417.468633777298 14398.009189026498 14585.586797015816 14830.761358987493 13418.154036501315 13060.371990172665 13183.69829846104 13088.73705016114 13372.642632411815 0.9608836504153155 0.9285725323789463 1.0766764344789608 1.0907034008120533 1.109037440590955 1.0034033216425893 0.9766485465271998 0.9858708305348097 0.9787696725281089 1.0 13.7069969710799 -10.026529571945176 11.934022554141551 0.999998013709253 1.0147826469615389 0.0024435930953812246 0.05703733840816156 0.0 0.0 0.062154047747276946 0.015074570818923902 9.407417709421284e-11 10.026529571945176 0.01478463325228585 RASS(ph)LNFLNK ddPTM_A459_Selumetinib_30min_R2 1 RASSLNFLNK 10 1 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 RAS(0.232)S(0.768)LNFLNK 74.649 0.031785 45300000.0 334980.0 345200.0 362000.0 354690.0 372750.0 254780.0 282820.0 261880.0 226210.0 342600.0 True False 316363.15263118653 371675.7300070544 338709.3141157986 306380.61012562143 325921.81257271994 289873.6323374346 295971.690397198 262642.02744343213 271458.3208354939 332708.247818298 0.9508725879376516 1.11712208051433 1.0180370229378202 0.9208686954251435 0.9796024436121453 0.8712547231343161 0.889583268037398 0.7894064218896938 0.8159049936860763 1.0 18.343898105427854 -6.33562514070668 0.9977292345277647 0.8551823205132225 1.038169888713086 0.44139630969331645 0.07020615567409334 0.4401055020126934 0.9317547465258712 0.032608077226300256 0.04678117506352789 4.617159306072479e-07 6.33562514070668 0.1829875681998634 RASS(ph)LNVLNVGGK ddPTM_A459_Selumetinib_30min_R1 2 RASSLNVLNVGGK 13 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;H0YJK1 Q07866-6 KLC1 Kinesin light chain 1 1 RAS(0.232)S(0.768)LNVLNVGGK;RAS(0.003)S(0.997)LNVLNVGGK 201.3 0.00017497 185252000.0 10291.7 9983.1 14280.6 15301.900000000001 12873.7 10792.7 9956.0 9333.5 6418.200000000001 7335.299999999999 True False 10531.476585837834 8814.274010982726 12341.372957720796 12629.710417237631 11709.276108036334 10684.135236987542 9205.010904378412 9085.945260519251 10891.216633218926 8276.857206872635 1.2724004199435857 1.0649300562614334 1.4910699374483851 1.5259065248522872 1.414700751187735 1.2908444558057663 1.1121384209377312 1.097753052085373 1.315863782713984 1.0 13.01486735277713 -7.121447223679115 4.033033863182677 1.140380881009384 1.3548631780332026 0.35991223242790715 0.13996993795997784 0.3059337840798807 8.502443716164786 0.06024008151232998 0.046165720788784316 7.560539319196316e-08 7.121447223679115 0.2144822970238185 RASWAS(ph)ENGETDAEGTQMTPAK ddPTM_A459_Selumetinib_30min_R2 1 RASWASENGETDAEGTQMTPAK 22 1 Q12789-3;Q12789 Q12789-3 GTF3C1 General transcription factor 3C polypeptide 1 1 RAS(0.392)WAS(0.582)ENGET(0.026)DAEGTQMTPAK 100.7 6.685e-05 31931000.0 52109.0 38188.0 45749.0 56062.0 53751.0 33927.0 42803.0 50568.0 48394.0 57153.0 True False 49212.99038885463 41116.89680622654 42805.559147745 48426.25888765577 46998.31883996317 38600.136291357834 44793.42431253548 50715.144508016914 58074.15224133728 55502.844388672536 0.8866751052293531 0.7408070209572539 0.7712318101751394 0.8725004893179671 0.8467731583420428 0.6954623085809933 0.8070473649757178 0.9137395581543793 1.0463274969235543 1.0 15.760274087593832 -7.973102593847335 2.8661048120701413 1.0202860396050706 0.7993938755240213 0.711619815687329 0.0563667233119511 0.14702630017999538 2.36320114450387 0.04236558862961146 0.015746384591345232 1.0638916642773725e-08 7.973102593847335 -0.22089216408104928 RAT(ph)ISSPLELEGTVSR ddPTM_A459_Selumetinib_30min_R1 2 RATISSPLELEGTVSR 16 1 Q96GS4 Q96GS4 C17orf59 Uncharacterized protein C17orf59 1 RAT(0.976)IS(0.022)S(0.002)PLELEGTVSR;RAT(0.952)IS(0.048)SPLELEGTVSR 133.92 0.00061798 13551700.0 1451.15 1661.6999999999998 1581.3600000000001 1826.29 1263.4 1567.51 1375.22 1377.31 789.0 1266.27 True False 1484.9589715536379 1467.1473914966284 1366.6199977887045 1507.3627352091507 1149.125693071386 1551.7422725852064 1271.486048204026 1340.7792646666055 1338.8753737200038 1428.808089014302 1.0392991073966225 1.0268330665098457 0.95647554650359 1.0549791443643364 0.804254750450173 1.0860396749683252 0.8898928120439126 0.9383900294066607 0.9370575264895509 1.0 10.480596437890485 -5.377970040572468 0.9984417776006549 0.9472431892419991 1.050802528886698 0.14225991139565763 0.07504876534368413 1.6939579724194291 2.4829397712413104 0.025733366749180874 0.15363109289123109 4.188224562246747e-06 5.377970040572468 0.10355933964469888 RAT(ph)ISSPLELEGTVSR ddPTM_A459_Selumetinib_30min_R2 2 RATISSPLELEGTVSR 16 1 Q96GS4 Q96GS4 C17orf59 Uncharacterized protein C17orf59 1 RAT(0.687)IS(0.252)S(0.061)PLELEGTVSR;RAT(0.737)IS(0.248)S(0.015)PLELEGTVSR 118.05 0.0022378 5776900.0 16061.2 11352.400000000001 11923.599999999999 16104.2 13812.0 12037.8 11618.4 11274.3 7408.5 11730.7 True False 15168.582802077786 12223.09257628067 11156.448557434082 13910.780178705469 12076.813079153333 13695.897681731583 12158.678621422836 11307.106346439155 8890.407010785371 11392.004210981075 1.3315113408627748 1.07295365678486 0.9793227206394521 1.2211003367867854 1.0601131157862593 1.2022377650220424 1.0672993440173364 0.9925475918925588 0.7804076303110612 1.0 13.475733964249438 -7.828277856528456 2.5606095150497983 0.8903269421148028 1.132448034301781 0.4703180745246026 0.10591805534560422 0.24766969606784706 3.209764870320444 0.06935487065688878 0.028782428315144545 1.4849852621013835e-08 7.828277856528456 0.2421210921869783 RAT(ph)PEPGDEGEPGR ddPTM_A459_Selumetinib_30min_R1 2 RATPEPGDEGEPGR 14 1 M0QZR4;M0QYC1;M0QZH8;M0QYS3 M0QZR4 ARHGEF1 1 RAT(1)PEPGDEGEPGR;RAT(1)PEPGDEGEPGR 124.91 0.0017755 144820000.0 6304.799999999999 7483.2 7723.9 8418.9 7840.6 6358.5 7187.099999999999 6974.4 4071.6 5800.799999999999 True False 6451.689572994774 6607.063465154699 6675.036804345739 6948.6971573256815 7131.419114370365 6294.539263056078 6644.971260632589 6789.416255956016 6909.20782210186 6545.38918457688 0.9856846386150889 1.0094225536234185 1.019807473033743 1.061617111125971 1.0895332444363073 0.9616753237359991 1.015214080209372 1.0372822859722606 1.055583957999359 1.0 12.676263261090245 -5.034351795347096 2.140300930610699 1.031922121398154 0.9849061870201986 0.15126320528457615 0.03336670382355416 0.8301627397985518 6.188068097585837 0.009547137273879154 0.061560610847117565 9.239494359055039e-06 5.034351795347096 -0.04701593437795537 RAT(ph)PEPGDEGEPGR ddPTM_A459_Selumetinib_30min_R2 1 RATPEPGDEGEPGR 14 1 M0QZR4;M0QYC1;M0QZH8;M0QYS3 M0QZR4 ARHGEF1 1 RAT(1)PEPGDEGEPGR 78.441 0.047542 103830000.0 102000.0 90309.0 122340.0 143890.0 146320.0 112140.0 97178.0 103890.0 119670.0 119070.0 True False 96331.24833835168 97235.40991079673 114468.77759372034 124291.93377590502 127937.97348260312 127586.26709443417 101696.96955455387 104192.30270008456 143607.34385917336 115632.13971898644 0.8330836787458875 0.8409029716746734 0.9899391109764695 1.07489089173619 1.1064222610904095 1.1033806639269939 0.8794870509332584 0.9010669780330677 1.2419327723950566 1.0 16.819182922177482 -5.328565025880143 3.288872107398395 1.0377890795137954 0.8316613358263129 0.4043860066425732 0.09872957738338962 0.2542892844861233 5.364712565685189 0.027612957802440982 0.06996438639778296 4.692831644042728e-06 5.328565025880143 -0.20612774368748255 RAVS(ph)PSNPK ddPTM_A459_Selumetinib_30min_R1 2 RAVSPSNPK 9 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 RAVS(0.995)PS(0.005)NPK;RAVS(0.999)PS(0.001)NPK 158.56 0.0015733 143541000.0 7366.9 9137.0 9751.6 10920.7 8586.1 9316.0 7780.4 6969.4 5173.2 6650.299999999999 True False 7538.534436507932 8067.235792323939 8427.386281704563 9013.604751927993 7809.48877099908 9222.289498251224 7193.518163964027 6784.5488721983 8778.5425644212 7503.930784407604 1.0046114034223543 1.0750679909104206 1.1230629018081837 1.201184420658215 1.0407197234849759 1.2289944781226119 0.9586333310684871 0.90413265622011 1.1698592133421737 1.0 12.873430805285574 -7.290062450306724 24.9814873015642 1.000167350469135 1.1118617452215211 0.24476704579230846 0.08915424614394436 996.8902922821534 870056.4056618714 0.03665098076455797 0.02471648272390667 5.1278764129052606e-08 7.290062450306724 0.11169439475238607 RAVS(ph)PSNPK ddPTM_A459_Selumetinib_30min_R2 4 RAVSPSNPK 9 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 RAVS(0.994)PS(0.006)NPK;RAVS(0.995)PS(0.005)NPK;RAVS(0.992)PS(0.008)NPK;RAVS(0.998)PS(0.002)NPK 90.697 0.014477 268581000.0 139784.0 150224.0 120466.0 136119.0 131458.0 98017.0 148901.0 144037.0 120614.0 144401.0 True False 132015.36487968796 161745.6977537071 112715.34871346378 117579.35738162776 114943.07079056895 111517.9520402637 155825.191541734 144456.1238233912 144740.17023673677 140231.76793114477 0.9414084042961567 1.153416947814035 0.8037789894284737 0.838464487157863 0.819664990938481 0.7952402917363215 1.1111975113816277 1.030124100655428 1.0321496503403256 1.0 17.097453687159323 -7.26927035148371 24.966322000337644 1.0458781572142024 0.8941476240982228 0.34816062508653356 0.10141976579091942 773.7747412705273 2466901.2657027217 0.045902883396609896 0.031596004867290174 5.3793480992157496e-08 7.26927035148371 -0.15173053311597962 RAVSEGCAS(ph)EDEVEGEA ddPTM_A459_Selumetinib_30min_R2 2 RAVSEGCASEDEVEGEA 17 1 Q9BYX2-6;Q9BYX2-5;Q9BYX2-4;Q9BYX2-2;Q9BYX2 Q9BYX2-6 TBC1D2 TBC1 domain family member 2A 1 RAVS(0.001)EGCAS(0.999)EDEVEGEA;RAVS(0.001)EGCAS(0.999)EDEVEGEA 135.61 0.00092672 23065000.0 65341.0 66204.0 72151.0 73539.0 82142.0 61524.0 53603.0 62059.0 56577.0 61009.0 True False 61709.60880074743 71281.63392058825 67508.8832120692 63522.8613381492 71822.5876012028 69998.37254073456 56095.64571232946 62239.581415579516 67893.98089346077 59247.51164958138 1.0415561275506067 1.2031160792402984 1.139438287490445 1.0721608312236695 1.212246482620174 1.1814567496899955 0.9468017162325131 1.0505011887029905 1.1459380993925756 1.0 15.854466942738489 -7.240518734248296 24.968955501729877 1.040018668961658 1.1444038815367303 0.36360189048281455 0.06845709907547409 900.6911113380111 1074983.825706329 0.026163307111013823 0.02024494046136754 5.747530250740739e-08 7.240518734248296 0.10438521257507238 RAVVVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 RAVVVSPK 8 1 G3V5E1;O75909-1;O75909 G3V5E1 CCNK Cyclin-K 1 RAVVVS(1)PK;RAVVVS(1)PK 65.695 0.043209 69514000.0 668520.0 537130.0 616410.0 606540.0 595920.0 449050.0 605710.0 604610.0 468420.0 463810.0 True False 631366.334697597 578326.1438548345 576750.8516964627 523928.2056601383 521055.20200760633 510902.5614299601 633876.7151915955 606369.315001426 562117.0887483419 450418.60017689824 1.4017323761710394 1.2839748261455046 1.2804774302614246 1.1632028638567984 1.1568243447383526 1.1342838888742766 1.4073058149522368 1.346235068363694 1.247988179279397 1.0 18.780906879627814 -11.439379196978798 2.1249806488816403 0.8233415511154694 1.2658346872309403 0.4321200222820759 0.09248275955605412 4921760.308778596 2105996.5127791897 4326037.849056685 0.026120171874133492 3.635974284639966e-12 11.439379196978798 0.4424931361154709 RCAT(ph)PVIIDEILPSK ddPTM_A459_Selumetinib_30min_R2 1 RCATPVIIDEILPSK 15 1 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 RCAT(1)PVIIDEILPSK 127.37 0.0013259 1179500.0 29065.0 28397.0 32576.0 34715.0 32357.0 26911.0 28096.0 27662.0 27518.0 30242.0 True False 27449.683656413643 30574.958589253547 30480.09562606704 29986.757113284766 28292.02438474982 30617.745976264676 29402.519671167818 27742.491840309387 33022.36891716161 29368.834881847586 0.9346534776352282 1.0410681496987628 1.037838094316309 1.021040066244477 0.9633349262430794 1.0425250473653969 1.0011469569513312 0.9446235082841704 1.1244017357178926 1.0 14.841998411861088 -8.258749931035618 24.999924762970082 1.0622008622063532 1.002188132205754 0.22666326480966714 0.04678483620722607 347.9305707195096 3234286.2968874746 0.03343570753151752 0.011336205924766266 5.511249455974528e-09 8.258749931035618 -0.06001273000059926 RCDELTR ddPTM_A459_Selumetinib_30min_R2 2 RCDELTR 7 1 P17844-2;P17844;J3KTA4;J3QSF1 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 0 ; 124.08 0.0091764 9434000.0 18093.300000000003 17349.0 15318.099999999999 22615.0 15117.3 11639.3 19151.199999999997 27816.0 18172.2 24641.0 False True 17087.746819218613 18679.612514172633 14332.550123086245 19534.79798694901 13218.129623623274 13242.507923954408 20041.768747382877 27896.939954813308 21807.147773691548 23929.550304993285 0.7140855804403888 0.7806085896346674 0.5989477420348985 0.8163462220546935 0.5523768501769588 0.5533956031422432 0.8375321931227784 1.1657945761309256 0.9113062090908217 1.0 14.546505664898403 -7.533297973438165 5.831286605366717 1.0267990095566841 0.6736205927897683 0.7153627206000581 0.10090278715814235 0.08451929963849078 10.522504944037168 0.04669546223242016 0.02776378609008145 2.9288830221349797e-08 7.533297973438165 -0.35317841676691586 RCLIDDR ddPTM_A459_Selumetinib_30min_R1 1 RCLIDDR 7 1 O95373 O95373 IPO7 Importin-7 0 101.6 0.026814 1970100.0 910.29 1036.4 1173.3 1300.7 1136.1 1061.9 846.14 982.4 606.77 717.5 False True 931.497985883995 915.0578061907116 1013.9723044755691 1073.5571621629322 1033.3399555947467 1051.2182501280563 782.3149785687773 956.3435607150702 1029.644373272607 809.5981140418407 1.150568374268538 1.1302617809006168 1.2524390643814742 1.3260371331688277 1.276361614080221 1.2984445392047053 0.9663003964561441 1.1812571498476163 1.2717969019618962 1.0 9.661062119053918 -7.223882239423604 24.995849910052364 1.1199431633761727 1.240338048984942 0.3032673101825998 0.09856554680783342 830.4901376693749 552726.8164238192 0.039542432758910846 0.030628594693215994 5.97197196889635e-08 7.223882239423604 0.12039488560876932 RCPT(ph)PEIQK ddPTM_A459_Selumetinib_30min_R1 1 RCPTPEIQK 9 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RCPT(1)PEIQK 97.957 0.025121 58459000.0 5791.2 7719.4 5519.8 6788.3 6606.3 6509.1 6520.1 6044.4 3120.6 5441.3 True False 5926.123692286408 6815.609059348301 4770.241478091066 5602.850837172782 6008.761331436998 6443.62436378994 6028.283607637376 5884.082877021754 5295.430280393718 6139.743857750341 0.9652069906476188 1.1100803579525227 0.776944704634458 0.9125544920086811 0.9786664510201024 1.0494940038347045 0.9818461074768997 0.9583596666812313 0.8624839086257928 1.0 12.583962754123746 -12.279987091181018 2.105576022532845 2.6704698559140985 0.957495771802113 0.022539226313776473 0.0874601289503104 12686722.831075836 1169170.601636988 99800826.79390803 0.02383556720536529 5.248230596770538e-13 12.279987091181018 -1.7129740841119854 RCPT(ph)PEIQK ddPTM_A459_Selumetinib_30min_R2 2 RCPTPEIQK 9 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RCPT(1)PEIQK;RCPT(1)PEIQK 94.402 0.029079 124659000.0 584990.0 485780.0 608940.0 643760.0 633770.0 492120.0 536780.0 594590.0 465119.0 529510.0 True False 552478.5977005141 523037.7639711107 569761.4633637427 556078.7774520576 554150.1466243133 559905.0629794272 561741.333609392 596320.1584603263 558155.7965106933 514221.67046779784 1.0743977343426876 1.0171445390375957 1.1080074918768381 1.081398955719197 1.0776483731620874 1.0888398819716607 1.0924108528883363 1.1596558307584388 1.0854381068828307 1.0 18.972030884331545 -5.271262365972574 24.98717534544392 1.092148299485596 1.0457711353059482 0.13725081052359833 0.0391419119978937 979.7512341485219 2492240.0564562525 0.009820700250285284 0.020846980845656473 5.354730698014781e-06 5.271262365972574 -0.04637716417964777 RCS(ph)DNTEVEVSNLENK ddPTM_A459_Selumetinib_30min_R2 2 RCSDNTEVEVSNLENK 16 1 Q9NQW6;Q9NQW6-2;C9JJT6 Q9NQW6 ANLN Actin-binding protein anillin 1 RCS(0.978)DNT(0.022)EVEVSNLENK;RCS(1)DNTEVEVSNLENK 211.9 1.7344e-08 18975000.0 111699.0 84339.0 86895.0 105315.0 109935.0 96299.0 107299.0 100715.0 97028.0 97128.0 True False 105491.21674652488 90807.53010737257 81304.27030412239 90970.91532149156 96123.9824686304 109563.31313471484 112288.61610893482 101008.06397573421 116436.31118883459 94323.6622711492 1.1183961076836975 0.9627226924918488 0.8619710934293414 0.9644548688109713 1.0190866231667923 1.1615676331539875 1.1904607328131762 1.0708666472827315 1.2344337400102094 1.0 16.525332113959713 -6.6259917829327435 3.896804616494954 1.1393636890968875 0.9697021000316309 0.4342376428200998 0.08387530574163596 0.20215041218532656 5.776542778348544 0.0285288215907349 0.02850076825318061 2.3659644622847712e-07 6.6259917829327435 -0.16966158906525652 RCS(ph)DPSLNEK ddPTM_A459_Selumetinib_30min_R1 2 RCSDPSLNEK 10 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 RCS(0.93)DPS(0.07)LNEK;RCS(1)DPSLNEK 103.76 0.0071233999999999985 16357900.0 8552.400000000001 10116.8 10724.6 11899.0 10437.4 9845.1 10333.7 9396.6 5171.5 7169.4 True False 8751.654279926492 8932.320352827279 9268.25822601099 9821.063021893391 9493.339012872642 9746.067232635585 9554.220689290401 9147.371643541566 8775.657788584283 8089.662325869792 1.0818318401176927 1.1041647961328083 1.1456916064805556 1.2140263247437144 1.1735148675506586 1.204755753706654 1.181040728824629 1.1307482655103347 1.0847990231336058 1.0 12.981863768410005 -8.503026731988681 1.7776345440509986 1.0012926274830392 1.1594830866642647 0.610387657753381 0.03912166875938148 0.26667340226622305 1.8861792852843349 0.04194221638455738 0.011991073330765302 3.140315393102956e-09 8.503026731988681 0.15819045918122554 RCS(ph)DPSLNEK ddPTM_A459_Selumetinib_30min_R2 4 RCSDPSLNEK 10 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 RCS(1)DPSLNEK;RCS(1)DPSLNEK;RCS(1)DPSLNEK;RCS(1)DPSLNEK 108.23 0.0055472 38427800.0 173798.0 150185.0 175293.0 186140.0 193106.0 115769.0 146991.0 153092.0 123014.0 157955.0 True False 164139.0029285183 161703.70657911233 164014.83922458763 160787.4108905896 168846.29789045648 131715.1289036523 153826.37275714087 153537.47237425513 147620.2372983403 153394.42873362338 1.070045400498563 1.0541693587836778 1.0692359597323258 1.0481958974520809 1.1007329228603602 0.8586695748408295 1.0028159042481757 1.000932521746798 0.9623572284668159 1.0 17.226886559726587 -6.727510118789505 24.999992655306748 0.9673794184095522 1.0665966797733462 0.611854599449007 0.04118972562239095 129.83760368781145 95667.5071561102 0.013319834436784212 0.01331916626062401 1.8727934475944884e-07 6.727510118789505 0.09921726136379394 RCS(ph)GLLDAPR ddPTM_A459_Selumetinib_30min_R2 1 RCSGLLDAPR 10 1 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 RCS(1)GLLDAPR 74.987 0.031354 3550400.0 14817.0 13980.0 15378.0 17902.0 15023.0 12275.0 13809.0 16925.0 12229.0 16341.0 True False 13993.530457150564 15052.221047215022 14388.596222300437 15463.716717327494 13135.676432675968 13965.76982864437 14451.145862014391 16974.24894791542 14675.141706808974 15869.192870983125 0.8818048007178604 0.9485183757983093 0.9066999398948661 0.9744488483470987 0.8277469773963487 0.8800554597947341 0.9106415165221391 1.0696353044490936 0.9247566543628393 1.0 13.953941132130733 -7.646366832250737 9.64960273847011 0.9977079339758621 0.904452993976449 0.4322085547196527 0.04934005069351982 0.2717990807556844 21.707070926577714 0.02279886905704107 0.013134672547488277 2.257528115393218e-08 7.646366832250737 -0.09325493999941314 RDAS(ph)EETSTSVMQK ddPTM_A459_Selumetinib_30min_R1 2 RDASEETSTSVMQK 14 1 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 RDAS(0.996)EET(0.001)S(0.001)T(0.001)SVMQK;RDAS(0.981)EET(0.005)S(0.005)T(0.009)SVMQK 127.2 0.0022189 8906000.0 2761.3 3039.5 3729.3 3691.7 3497.5 2852.8 3707.0 3030.2 1617.65 2727.3999999999996 True False 2825.632917445513 2683.633926974784 3222.8815435785737 3047.0138967916505 3181.151742533778 2824.1034221351533 3427.3780054771764 2949.829252523216 2745.033901518585 3077.4883571257383 0.9181620170561916 0.8720208220320288 1.0472441060958642 0.990097619617788 1.0336844118899795 0.9176650223862302 1.113693248437899 0.9585184118383632 0.8919721483795787 1.0 11.587537683321866 -5.251196962785331 24.982012312863056 0.9954387011232719 0.8950914108376906 0.2955254728612877 0.061124213230213005 842.8650408985815 2055800.6032598547 0.015312295570780681 0.03955601204744444 5.607935852400151e-06 5.251196962785331 -0.10034729028558131 RDAS(ph)EETSTSVMQK ddPTM_A459_Selumetinib_30min_R2 1 RDASEETSTSVMQK 14 1 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 RDAS(0.985)EET(0.007)S(0.007)T(0.002)SVMQK 154.88 0.00019024 0.0 14119.0 14176.0 20389.0 18066.0 23423.0 14705.0 13350.0 14933.0 12160.0 16788.0 True False 13334.322502835179 15263.25361697568 19077.193937864704 15605.379634411696 20480.39333572319 16730.48027130065 13970.801452523145 14976.45255770876 14592.339778787882 16303.286819537649 0.8178916711969698 0.9362071455851708 1.170144042059227 0.9571922402610503 1.2562125393745605 1.0262029035305358 0.856931587303041 0.9186155358415932 0.8950550855365318 1.0 13.992875227455043 -7.195810008016849 8.034992565107022 0.9110242358110071 1.0372176380847742 0.16571730394172124 0.11899023651066928 0.5568021065504486 62.78457477715849 0.047055072308990815 0.036369247216072875 6.370741625136165e-08 7.195810008016849 0.12619340227376707 RDDFFYEDR ddPTM_A459_Selumetinib_30min_R2 1 RDDFFYEDR 9 1 G3V1T9;J3KPD3;Q9Y580 G3V1T9 RBM7 RNA-binding protein 7 0 173.64 0.00055719 2527200.0 7596.3 8391.4 11495.0 9833.9 9823.4 7835.0 5393.5 8630.1 8914.6 8391.0 False True 7174.128056398246 9034.993397396287 10755.424214809687 8494.505855576293 8589.296669689757 8914.200130951413 5644.3084370175 8655.212162210037 10697.769094735404 8148.730027563757 0.8803982991375541 1.108760919411328 1.3198896243253329 1.0424330940947757 1.0540656814786777 1.093937349844502 0.6926611162629216 1.0621547324470269 1.3128142739481257 1.0 12.99235951876648 -6.434695631423914 2.165673818004875 1.0173784995222626 1.1059112217410452 0.018341108034082176 0.1733231671065308 1.2336479829282718 11.444155058847048 0.0645991816657271 0.07384944932378366 3.675397948423611e-07 6.434695631423914 0.08853272221878261 RDDGSWEVIEGYR ddPTM_A459_Selumetinib_30min_R1 1 RDDGSWEVIEGYR 13 1 P49448;P00367 P49448 GLUD2;GLUD1 Glutamate dehydrogenase 2, mitochondrial;Glutamate dehydrogenase 1, mitochondrial 0 201.09 6.637e-22 0.0 581.47 912.35 826.5 833.53 796.25 849.49 771.83 788.88 271.38 630.16 False True 595.0171196563372 805.5316378599924 714.2658396395282 687.9696327959325 724.2293280893558 840.9449018752076 713.6102416961019 767.9563397566212 460.51203918901757 711.0471742781971 0.8368180638089939 1.1328807243734693 1.0045266551612393 0.9675442891595889 1.0185390706665 1.1826851048650509 1.003604637653622 1.0800357100584699 0.6476532863751208 1.0 9.473801468099742 -8.236320563587288 24.92143281924229 0.8238265440718003 1.0329894505107338 0.32076903973250936 0.11887944885489217 680.9949926754737 675645.936528427 0.07493918773408229 0.028299505800034888 5.8033589899152044e-09 8.236320563587288 0.20916290643893343 RDDGTGQLLLPLSDAR ddPTM_A459_Selumetinib_30min_R1 2 RDDGTGQLLLPLSDAR 16 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 153.41 0.00019429 8599100.0 3676.1 4094.2 4827.9 4394.2 4452.3 3488.8 3602.0 3587.0 2272.6 2936.4 False True 3761.7459775545767 3614.8491606580565 4172.297697756416 3626.8354593498543 4049.5902511174068 3453.705839576952 3330.2982400131646 3491.8611077819196 3856.4362158632216 3313.315542958135 1.1353419041387414 1.091006610686621 1.2592515393301114 1.0946242252893934 1.2222168998434493 1.042371544393709 1.0051255900124343 1.0538872807340223 1.1639206003362381 1.0 11.694059889404052 -6.780634830277516 24.96403703910337 1.0534329608910447 1.15845588765328 0.4134405711014616 0.06395478737032627 248.44739761245813 323108.26509333245 0.022138562671780364 0.0195534109726904 1.657162777226854e-07 6.780634830277516 0.10502292676223535 RDDGTGQLLLPLSDAR ddPTM_A459_Selumetinib_30min_R2 2 RDDGTGQLLLPLSDAR 16 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 113.52 0.0030552 5985100.0 25290.0 25513.0 27031.0 31251.0 28480.0 22196.0 23011.8 20526.1 19741.1 24549.0 False True 23884.483043891316 27469.765062775157 25291.85488912752 26994.55988901807 24902.08778556958 25253.29752477315 24081.894297016654 20585.827552721224 23689.871612420193 23840.206584037987 1.0018572179606435 1.152245261212095 1.0608907603200668 1.13231233101361 1.044541610735981 1.0592734352260724 1.0101378195749564 0.863491995346395 0.9936940575121337 1.0 14.54110911687955 -7.384416847344127 2.7961670193703507 0.9454131406417565 1.080747513395314 0.5069064970458084 0.053722162531764456 0.197620927116906 2.983257807678902 0.024559031205959144 0.015172833073158415 4.1265123826262e-08 7.384416847344127 0.13533437275355742 RDDNSAANNSANEKER ddPTM_A459_Selumetinib_30min_R1 2 RDDNSAANNSANEKER 16 2 P78344-2;P78344;H0Y3P2;D3DQV9;H0YCH5;H0YD77;H0YD99;H0YEN8;H0YDC0;H0YCF8;H0YEC5;H0YEI7 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 ; 94.532 0.005823399999999999 1752890.0 613.11 463.66999999999996 761.62 978.71 633.67 757.36 508.44 479.59 503.046 426.346 False True 627.3942700956139 409.383300845665 658.1961872791982 807.7966711620539 576.3546603835247 749.74164602786 470.08796145260783 466.86971527213 853.6323209738318 481.07166206171854 1.3041596909009434 0.8509819495315516 1.3681874015575577 1.679160788020847 1.1980640429192062 1.5584822494318378 0.977168265197667 0.9704785213730455 1.7744390041920948 1.0 8.910108008510743 -8.224009358595856 24.998376322956 1.3872224762584373 1.2450698562573441 0.037147200717515094 0.3016415716797658 2077.9764369835025 1387821.435242604 0.20383282005422562 0.07703677074412503 5.970224212309702e-09 8.224009358595856 -0.1421526200010932 RDEDMLY(ph)S(ph)PELAQR ddPTM_A459_Selumetinib_30min_R2 1 RDEDMLYSPELAQR 14 1 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 2 RDEDMLY(1)S(1)PELAQR 96.059 0.012806 12409000.0 32206.0 41015.0 36399.0 39449.0 32364.0 21387.0 18201.0 21034.0 14482.0 30336.0 True False 30416.11945083289 44160.71861598884 34057.12796823473 34075.978146679256 28298.144982169026 24332.865118143953 19047.382564597283 21095.205457633852 17378.804660888676 29460.12085760624 1.0324505998413045 1.4989999134571466 1.15604169218612 1.1566815462632856 0.9605576677348489 0.8259594465262183 0.6465480116888075 0.7160597052400527 0.5899094828866489 1.0 14.846475728467391 -6.454963466228064 1.366798208754069 0.7136110173243881 1.2587464862435476 0.676350622560071 0.14912946769881355 0.21914848395390807 0.838836901712155 0.05845663735995298 0.06915861279446892 3.507813811844133e-07 6.454963466228064 0.5451354689191594 RDEDMLYS(ph)PELAQR ddPTM_A459_Selumetinib_30min_R1 2 RDEDMLYSPELAQR 14 1 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 1 RDEDMLYS(1)PELAQR;RDEDMLYS(1)PELAQR 160.76 0.00014798 19083000.0 3403.3 4589.4 2788.7 3319.6000000000004 3914.3 3313.0 4388.4 4000.2 1881.44 3626.3 True False 3482.5902683309737 4052.070914445823 2410.00985723261 2739.8941766095722 3560.252256125795 3279.6742279633213 4057.3794548788883 3894.101701519162 3192.66626505927 4091.770928153213 0.8511205366774557 0.9902975962231325 0.5889894374708674 0.6696108420336719 0.8701005795875982 0.8015292853756051 0.9915949661214669 0.951691033025823 0.7802651519644707 1.0 11.99850966482159 -7.178149416698979 7.1176698874154125 0.9265907403993425 0.7917663117800556 0.2433783189803389 0.11697835705577633 0.43192391195980234 31.93591259714637 0.04761129394600781 0.03678972045088341 6.635147524185047e-08 7.178149416698979 -0.1348244286192869 RDEDMLYS(ph)PELAQR ddPTM_A459_Selumetinib_30min_R2 4 RDEDMLYSPELAQR 14 1 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 1 RDEDMLYS(1)PELAQR;RDEDMLY(0.001)S(0.999)PELAQR;RDEDMLY(0.003)S(0.997)PELAQR;RDEDMLY(0.012)S(0.988)PELAQR 132.87 0.00039658 59635400.0 72605.0 51676.5 70903.6 70736.8 81906.0 65960.0 72216.0 82633.0 75231.0 59604.2 True False 68569.90476084338 55639.92138386312 66341.73957000257 61102.32581221373 71616.23603106954 75045.39127473578 75574.1870932893 82873.44834937042 90279.30212976919 57883.27187569012 1.1846238565799083 0.9612435437885264 1.1461297438831346 1.0556128538040632 1.2372527279534624 1.2964953231376235 1.3056308782197406 1.4317339995456562 1.5596786291495865 1.0 15.820858852653037 -6.569268529544568 1.5416880462098135 1.3580245546146064 1.076237094799138 0.35027848126749317 0.14480589259939292 0.37412733319056574 1.8259111774354881 0.057000049637628926 0.06051073977220497 2.696071903020061e-07 6.569268529544568 -0.2817874598154684 RDFTNEAPPAPLPDASASPLS(ph)PHR ddPTM_A459_Selumetinib_30min_R1 1 RDFTNEAPPAPLPDASASPLSPHR 24 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 RDFTNEAPPAPLPDAS(0.256)AS(0.134)PLS(0.609)PHR 71.37 0.007376100000000002 0.0 459.05 625.9 804.93 899.59 759.26 799.94 730.19 710.39 474.89 641.13 True False 469.7449718441908 552.619337026984 695.6249271639994 742.4934938957119 690.5850670582402 791.8933298874072 675.1111804206587 691.5481495280733 805.8536454067078 723.4252806350462 0.6493344709101587 0.763892763799845 0.9615712165233667 1.0263582345973963 0.9546045535649821 1.0946442584813423 0.9332148025405252 0.9559358347568526 1.1139417808281502 1.0 9.498700204701684 -5.145314511007331 2.0424691483831174 1.0084034245626148 0.6406392576769163 0.8311391257997537 0.05534880170181703 0.14768962502629643 1.0549912391109872 0.015020571759688378 0.07581696344477461 7.156249752381832e-06 5.145314511007331 -0.36776416688569846 RDFTNEAPPAPLPDASASPLS(ph)PHR ddPTM_A459_Selumetinib_30min_R2 1 RDFTNEAPPAPLPDASASPLSPHR 24 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 RDFTNEAPPAPLPDAS(0.007)AS(0.041)PLS(0.953)PHR 76.762 0.00019302 2928900.0 15123.0 12601.0 10818.0 15114.0 14855.0 10915.0 11436.0 11671.0 12039.0 11373.0 True False 14282.52420216562 13567.456181398886 10121.98165774783 13055.44712689575 12988.78209461503 12418.44217349518 11967.796660004109 11704.96067776194 14447.136397765405 11044.63193939728 1.293164342690177 1.2284208523963975 0.9164616542486792 1.1820626706740398 1.1760267038218608 1.124387144962014 1.0835849239406348 1.0597873013775319 1.3080686144217317 1.0 13.431057721460933 -5.0156434415442686 24.578011050869783 1.1107289390060036 1.276978581126678 0.280864705047867 0.10103281456179039 621.0194571412502 975719.6424686527 0.02469656316224525 0.07035846027819788 9.646206581375475e-06 5.0156434415442686 0.1662496421206745 RDGPGLER ddPTM_A459_Selumetinib_30min_R2 1 RDGPGLER 8 1 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 0 96.034 0.028961 743570.0 4326.9 4052.6 5364.4 4798.4 5578.2 2920.3 4848.6 4715.6 2812.2 4270.6 False True 4086.4282199530794 4363.421388837167 5019.260344317102 4144.849642298304 4877.416646259279 3322.5448171560224 5074.069507318634 4729.321615290395 3374.718579433165 4147.296681648645 0.9853233403906447 1.052112188680605 1.2102486823589942 0.9994099676154907 1.1760471990926857 0.8011350699500078 1.223464318280113 1.140338388670661 0.8137152556184231 1.0 12.017955540450298 -8.25577125911574 24.963699831146766 0.906857624938611 1.0742218302454034 0.21583401496833632 0.127056058402731 619.2335836663457 2727276.877585836 0.08782449150836406 0.031136348614578736 5.5491790868436855e-09 8.25577125911574 0.1673642053067924 RDHALLEEQSK ddPTM_A459_Selumetinib_30min_R1 1 RDHALLEEQSK 11 1 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 198.52 2.4362e-19 0.0 4057.0 4322.8 4648.0 4366.0 3598.1 3629.9 3394.5 3436.9 2175.9 2933.8 False True 4151.520206452199 3816.684566384804 4016.8271296364514 3603.560059970297 3272.6524902961496 3593.3865016854998 3138.450132072371 3345.7422473754327 3692.343378551784 3310.3818076319926 1.254091052845018 1.1529439164949324 1.2134029737523837 1.088563274381943 0.9886027293743401 1.0854900463146118 0.9480628865337413 1.0106816801801888 1.11538293559951 1.0 11.692781906592021 -5.911183418640633 3.3813296085696636 1.024743752309206 1.2020979359941353 0.7208832782679577 0.05051386063151796 0.12611625830310255 2.8630819309813402 0.014518324415728447 0.022549994029297055 1.2269209475747177e-06 5.911183418640633 0.17735418368492928 RDHALLEEQSK ddPTM_A459_Selumetinib_30min_R2 2 RDHALLEEQSK 11 1 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ; 82.171 0.027326 80793000.0 817740.0 774650.0 821810.0 846510.0 852080.0 681150.0 660130.0 796450.0 572970.0 809430.0 False True 772293.2844725861 834063.1641076609 768935.6393190736 731213.8776888008 745034.0927081497 774972.2296359356 690827.3530227799 798767.5376406045 687580.0101194149 786059.6527482948 0.982486865688148 1.0610685349280196 0.9782153766964752 0.9302269555907913 0.947808592011169 0.9858949342157504 0.8788485080075604 1.0161665655372074 0.8747173420177894 1.0 19.58427927478145 -5.500415760639089 6.0874151482325525 0.9474398939708135 1.0218419941286525 0.280518513123136 0.047275765776912435 0.19366888442279573 25.4643648024499 0.011517324826889977 0.022860325386045117 3.1592517836831986e-06 5.500415760639089 0.07440210015783899 RDHFEEAMR ddPTM_A459_Selumetinib_30min_R1 2 RDHFEEAMR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ; 145.46 0.002502 13111000.0 3488.2000000000003 4324.9 4897.6 4904.7 4196.6 3757.0 3451.8999999999996 3601.0 2004.9 3243.2 False True 3569.468273144331 3818.5386974085363 4232.532820591108 4048.1862176216905 3817.0182709699097 3719.207991083066 3191.520403859366 3505.489782303508 3402.168867897639 3659.4963114432044 0.9753987897139405 1.0434601847986589 1.1565889019633726 1.1062140450758366 1.0430447105614333 1.0163169120988438 0.8721201313633019 0.9579159217463563 0.9296822782029031 1.0 11.837429376070405 -6.9585841777279835 2.9825445518533367 0.9364483564527566 1.0716429445737834 0.5439512485932826 0.053374842069717356 0.1982744551848783 3.6027418203273496 0.021904480188153573 0.018207038490315054 1.100058604251704e-07 6.9585841777279835 0.1351945881210268 RDHFEEAMR ddPTM_A459_Selumetinib_30min_R2 2 RDHFEEAMR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ; 106.18 0.01802 4820200.0 15096.3 13378.7 18258.7 15454.4 16299.3 16363.9 13232.2 14880.2 12000.8 18058.1 False True 14257.30808127704 14404.803270699249 17083.95512056945 13349.484059672994 14251.636216409208 18617.878688305802 13847.52351910688 14923.498918450281 14401.29533036824 17536.715732421533 0.8129976159058341 0.8214082665471923 0.9741821320046247 0.7612305669637293 0.812674187907435 1.0616513931331757 0.7896303806479484 0.8509859626030211 0.8212082324938079 1.0 14.098090965404827 RDHRPPCAQEAPR ddPTM_A459_Selumetinib_30min_R1 3 RDHRPPCAQEAPR 13 2 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 0 ;; 96.334 0.0090493 5248000.0 668.4100000000001 609.868 439.99 634.26 661.82 625.01 622.35 712.1099999999999 260.03 390.0 False True 683.9826525005452 538.464371040059 380.2417746920701 523.4983975347593 601.9584978538113 618.7229668636747 575.4056384431408 693.2225295407255 441.25191816021885 440.0602989216976 1.554293023425524 1.2236149735831336 0.8640674371757601 1.1896060581186587 1.3679000339926624 1.4059958791551146 1.3075608952979554 1.5752898665009418 1.002707854449586 1.0 8.78155741124048 -4.760156101567229 24.17274381322191 1.2350202623069886 1.5542935853116455 0.19337163643634347 0.20419044086891056 40.101921555816354 754921.6155032857 0.052651755866444584 0.3174574992521636 1.737176310830848e-05 4.760156101567229 0.31927332300465694 RDHRPPCAQEAPR ddPTM_A459_Selumetinib_30min_R2 1 RDHRPPCAQEAPR 13 2 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 0 77.597 0.027142000000000003 2034600.0 0.0 0.0 506.77 0.0 0.0 0.0 719.0 0.0 443.01 0.0 False True 0.0 0.0 474.1649699294568 0.0 0.0 0.0 752.4349246714711 0.0 531.6243787336206 0.0 0.0 RDHVFEDSYR ddPTM_A459_Selumetinib_30min_R2 1 RDHVFEDSYR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 131.12 0.0017977999999999996 3243200.0 3164.1 3880.2 3792.1 3724.7 4475.1 3132.1 2733.7 3570.4 3641.0 3724.0 False True 2988.2519888958673 4177.798863190535 3548.120414526303 3217.389434534112 3912.8979300983992 3563.5183446270516 2860.822466723785 3580.7892728884617 4369.301738040028 3616.4784438860024 0.8262877921885 1.1552118802902025 0.9810981786784144 0.8896470653581281 1.081963570587161 0.9853558924570711 0.7910519891416123 0.990131512864987 1.2081647397696353 1.0 11.820369837127927 -8.02663155980752 24.09996401558663 1.1024377307418265 0.964511055152126 0.2040839516182661 0.11284571861196978 768.7346595072978 695651.988556147 0.07420868525365483 0.02826678336369802 9.405208770980961e-09 8.02663155980752 -0.1379266755897005 RDIEDLR ddPTM_A459_Selumetinib_30min_R1 1 RDIEDLR 7 1 H7BZW2;Q6P2H3-3;Q6P2H3-4;Q6P2H3-2;Q6P2H3 H7BZW2 CEP85 Centrosomal protein of 85 kDa 0 110.12 0.021042 18791000.0 5817.6 6649.9 7587.0 7526.9 6949.0 6544.3 6271.7 5674.1 3479.2 5215.0 False True 5953.138760920949 5871.326616545361 6556.727072407864 6212.46821241191 6320.464176945593 6478.470283748978 5798.620619625365 5523.60443592567 5903.94828928598 5884.396048401673 1.0116822035692086 0.9977789680115323 1.114256589542237 1.0557529033246067 1.0741058428013806 1.1009575546004704 0.9854232400282428 0.9386867217113978 1.003322726873494 1.0 12.522678634897996 -7.368675935970793 6.667538973058904 0.9754425509940902 1.0591853903540356 0.5073859417036573 0.03715296825880186 0.20866518595368874 11.291120835781644 0.01643534998941849 0.011003916027793582 4.278820462264201e-08 7.368675935970793 0.08374283935994542 RDLFAFQES(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 RDLFAFQESPPR 12 1 E7EX48;P51957-3;P51957-2;P51957 E7EX48 NEK4 Serine/threonine-protein kinase Nek4 1 RDLFAFQES(1)PPR;RDLFAFQES(1)PPR 105.63 0.004744600000000001 3904500.0 14949.7 16333.1 18272.8 19443.1 18137.2 14001.099999999999 12444.3 14427.0 11982.400000000001 19344.5 True False 14118.855522390757 17585.796250805968 17097.14794192037 16794.9162387817 15858.64278737473 15929.624435668651 13022.984607912644 14468.98018148157 14379.214816229287 18785.974021952934 0.7515636669087122 0.9361130932181392 0.910101755806804 0.8940135986111489 0.844174636292088 0.8479530748341073 0.693229139606721 0.7702012237732998 0.7654229053774911 1.0 14.197368298840898 -7.018501610978671 22.357693962733528 0.7855673572783771 0.8720128800781833 0.0733534114515666 0.08745069119506911 328.81699038444106 397347.3008287444 0.03140538221321191 0.02485730926838749 9.582931615923011e-08 7.018501610978671 0.08644552279980622 RDLNES(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 RDLNESPVK 9 1 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 RDLNES(1)PVK;RDLNES(1)PVK 87.001 0.016992 30176000.0 13931.1 16638.699999999997 16096.0 17095.0 15820.5 15039.8 15400.5 14965.8 9138.099999999999 12894.9 True False 14255.667524798168 14690.633268878224 13910.2516089992 14109.679162893308 14389.538568336136 14888.513267045813 14238.82788598632 14568.85836823045 15506.688279582728 14550.086021962565 0.979765171372871 1.0096595474902013 0.9560253862418704 0.9697316663004957 0.9889658759828573 1.02325946695933 0.9786078147231283 1.001290187991985 1.0657454709323522 1.0 13.828740062105135 -8.035363477160242 10.097366254025571 1.0331637997068368 0.9873348405437072 0.3837305276101023 0.023187693701232456 0.6340124282922697 176.47352410939428 0.015166719822751596 0.00585767667965527 9.217996159322206e-09 8.035363477160242 -0.04582895916312957 RDLNES(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 RDLNESPVK 9 1 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 RDLNES(1)PVK;RDLNES(1)PVK 81.92 0.021897 34750000.0 145321.0 142606.0 167028.0 154436.0 177054.0 125986.0 131378.0 127557.0 119068.0 132852.0 True False 137244.6405860551 153543.42164943778 156281.600326336 133401.55038303998 154810.893637157 143339.42791296064 137487.33732056842 127928.16975180201 142884.92703788818 129016.21756905044 1.0637782068955846 1.1901094648605723 1.2113329879841883 1.0339905548048056 1.1999335940406177 1.1110186813238756 1.065659340438997 0.9915665810256288 1.1074958616068178 1.0 16.97719290082844 -7.259899718524681 2.907001758143459 1.036722489292122 1.1413977439101024 0.3719171986405192 0.060988965673315486 0.286558510941765 4.887592858335209 0.02662108593020025 0.018120679723622978 5.496677811402514e-08 7.259899718524681 0.10467525461798033 RDPGPSGKADPMPLES(ph)MDS(ph)ASTGK ddPTM_A459_Selumetinib_30min_R2 1 RDPGPSGKADPMPLESMDSASTGK 24 2 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 2 RDPGPS(0.002)GKADPMPLES(0.887)MDS(0.373)AS(0.369)T(0.369)GK 45.369 0.044232 10379000.0 3590.3 1235.3 4333.6 5834.6 6299.1 5234.1 2263.1 4369.0 4643.4 5189.4 True False 3390.765499109648 1330.043537884457 4054.7808940669233 5039.917414753601 5507.750743331506 5955.0497645708765 2368.3386342475765 4381.7130666731155 5572.209747436161 5039.5685383195505 0.6728285315155774 0.2639201208935163 0.8045888974890287 1.0000692274410792 1.092901247686587 1.1816586517854153 0.4699486902974637 0.8694619456716829 1.105691827597253 1.0 12.29908450761899 -5.452146457208265 5.140875920979974 0.9464381445109308 0.4728062409554715 0.4687779746495786 0.2062793375702405 0.1910780800919889 9.41054614313785 0.05670298604596208 0.11956259775556585 3.5306408584692028e-06 5.452146457208265 -0.47363190355545925 RDPHLACVAYER ddPTM_A459_Selumetinib_30min_R1 2 RDPHLACVAYER 12 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 ; 82.20200000000001 0.024822 9823100.0 5382.3 5911.799999999999 6681.4 7919.0 6316.1 4956.6 5601.299999999999 5274.7 3073.7 4393.200000000001 False True 5507.6971178673075 5219.6437076787415 5774.102578303135 6536.095308040489 5744.809870198027 4906.741104232719 5178.7894313675 5134.797821359712 5215.844405834193 4957.110013391803 1.1110701806068606 1.0529610385038248 1.1648122722118732 1.3185294032980917 1.1589030412232584 0.9898390576317633 1.0447194872368826 1.035845040252865 1.0521946036588679 1.0 12.275283561629209 -6.749556347796653 24.172889796848764 1.028022450993585 1.1641739752533558 0.524918888818954 0.06496893814816541 137.34983275351752 279401.1307044873 0.024033262160005706 0.023837415822988744 1.7800969341313586e-07 6.749556347796653 0.13615152425977084 RDPHLACVAYER ddPTM_A459_Selumetinib_30min_R2 1 RDPHLACVAYER 12 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 76.357 0.032328 8644800.0 32137.0 21674.0 37350.0 38037.0 40436.0 27981.0 23798.0 26510.0 22978.0 33330.0 False True 30350.954194604015 23336.32610710575 34946.941663605205 32856.294982515115 35356.068177573434 31835.12876377176 24904.654154842392 26587.13971103324 27574.24205896285 32367.676298260027 0.9376933306835986 0.7209762570555684 1.0796864545226508 1.015095883922979 1.092326426270954 0.9835469333794316 0.769429783137728 0.8214102077034944 0.8519067542839072 1.0 14.982266176566743 -7.2407339352196 23.935566565191053 0.8458042016837779 0.9725482374942153 0.1893192290388913 0.11068049684052383 748.6335162635974 865423.5682180554 0.04467280808697421 0.03455510086830154 5.7446829483971213e-08 7.2407339352196 0.12674403581043736 RDPSSNDINGGMEPTPS(ph)TVSTPSPSADLLGLR ddPTM_A459_Selumetinib_30min_R1 1 RDPSSNDINGGMEPTPSTVSTPSPSADLLGLR 32 1 O95782-2;O95782 O95782-2 AP2A1 AP-2 complex subunit alpha-1 1 RDPSSNDINGGMEPT(0.005)PS(0.441)T(0.441)VS(0.007)T(0.038)PS(0.064)PS(0.005)ADLLGLR 186.31 1.1371e-40 99308000.0 810.64 1199.7 972.19 1108.9 1317.3 976.09 1270.3 1080.7 440.51 803.6 True False 829.5263347691422 1059.2385662746012 840.1719378574144 915.2514316310262 1198.1504475882052 966.2714208188098 1174.4802482756022 1052.0363253916707 747.5132964225595 906.7498877268621 0.914834780789097 1.1681706064833535 0.9265751771567875 1.0093758422462855 1.3213681785964786 1.0656427245236972 1.2952637371920888 1.160227687514832 0.8243875257558686 1.0 9.824560851336798 -4.746598392473537 24.35556155853164 1.0966089869411555 0.9148341134777613 0.10270212546501467 0.1483464437398993 1339.91100662883 2198756.366801226 0.03704952876287407 0.7941530386982134 1.7922624566831872e-05 4.746598392473537 -0.18177487346339416 RDPSSNDINGGMEPTPSTVSTPS(ph)PSADLLGLR ddPTM_A459_Selumetinib_30min_R1 6 RDPSSNDINGGMEPTPSTVSTPSPSADLLGLR 32 1 O95782-2;O95782 O95782-2 AP2A1 AP-2 complex subunit alpha-1 1 RDPS(0.044)S(0.044)NDINGGMEPT(0.036)PS(0.017)T(0.033)VS(0.111)T(0.228)PS(0.386)PS(0.101)ADLLGLR;RDPSSNDINGGMEPTPST(0.009)VS(0.105)T(0.362)PS(0.481)PS(0.042)ADLLGLR;RDPSSNDINGGMEPTPS(0.03)T(0.03)VS(0.019)T(0.049)PS(0.436)PS(0.436)ADLLGLR;RDPSSNDINGGMEPT(0.015)PS(0.005)T(0.005)VS(0.004)T(0.004)PS(0.699)PS(0.268)ADLLGLR;RDPSSNDINGGMEPT(0.005)PS(0.005)T(0.005)VS(0.008)T(0.008)PS(0.751)PS(0.218)ADLLGLR;RDPSSNDINGGMEPTPSTVS(0.036)T(0.036)PS(0.703)PS(0.224)ADLLGLR 192.98 3.2614999999999997e-41 149510500.0 4760.1 5757.36 5739.0599999999995 5959.599999999999 5300.660000000001 5094.9 5796.669999999999 5360.179999999999 3021.67 4340.98 True False 4871.001068457754 5083.285614675953 4959.727174400034 4918.867735547175 4821.216238907532 5043.64993179907 5359.422514974206 5218.010614081543 5127.553295955036 4898.187067725923 0.9944497833806109 1.0377891951431666 1.0125638538959847 1.0042221065743928 0.9842858535710997 1.0296972863759328 1.0941645226837815 1.0652942694783816 1.0468267595862975 1.0 12.258032157895721 -7.004828885467115 24.770043105768007 1.0577151977677859 1.0084245292589102 0.39908245963780664 0.02551596540976851 168.73525754371062 865541.284551828 0.008925334490407704 0.007668462730871395 9.889426670246128e-08 7.004828885467115 -0.049290668508875646 RDPSSNDINGGMEPTPSTVSTPS(ph)PSADLLGLR ddPTM_A459_Selumetinib_30min_R2 9 RDPSSNDINGGMEPTPSTVSTPSPSADLLGLR 32 1 O95782-2;O95782 O95782-2 AP2A1 AP-2 complex subunit alpha-1 1 RDPSSNDINGGMEPTPSTVS(0.001)T(0.001)PS(0.834)PS(0.164)ADLLGLR;RDPSSNDINGGMEPTPS(0.007)T(0.007)VS(0.146)T(0.146)PS(0.347)PS(0.347)ADLLGLR;RDPSSNDINGGMEPTPST(0.001)VS(0.008)T(0.006)PS(0.746)PS(0.238)ADLLGLR;RDPSSNDINGGMEPTPSTVS(0.009)T(0.027)PS(0.723)PS(0.241)ADLLGLR;RDPSSNDINGGMEPT(0.001)PS(0.001)T(0.001)VS(0.029)T(0.033)PS(0.688)PS(0.247)ADLLGLR;RDPSSNDINGGMEPTPS(0.004)T(0.004)VS(0.066)T(0.066)PS(0.581)PS(0.278)ADLLGLR;RDPSSNDINGGMEPTPSTVS(0.017)T(0.017)PS(0.77)PS(0.195)ADLLGLR;RDPSSNDINGGMEPTPS(0.002)T(0.002)VS(0.023)T(0.023)PS(0.721)PS(0.227)ADLLGLR;RDPSSNDINGGMEPTPS(0.001)T(0.001)VS(0.015)T(0.047)PS(0.824)PS(0.113)ADLLGLR 186.0 1.1752e-40 114728500.0 151840.2 159140.09999999998 183751.2 189576.19999999998 201137.1 140381.90000000002 136491.5 147318.0 132041.6 166085.30000000002 True False 143401.5295484802 171345.63395392694 171928.84784517967 163755.59452281435 175868.45930951153 159718.23246499166 142838.6252027763 147746.6709901921 158453.60955055928 161289.98584756677 0.8890913393966521 1.0623451484202102 1.065961082095125 1.0152868057014885 1.0903867241684968 0.9902551086831853 0.8856013251670279 0.916031272578979 0.9824144302443667 1.0 17.299297341842035 -7.004646886663435 24.795543555427184 0.9388591927551567 1.0296724128708226 0.27662991237677015 0.05918898385291658 206.99499560192368 1104519.0090544445 0.020901236365242624 0.017960846827000942 9.893571878355339e-08 7.004646886663435 0.09081322011566584 RDPSSNDINGGMEPTPSTVSTPSPS(ph)ADLLGLR ddPTM_A459_Selumetinib_30min_R2 1 RDPSSNDINGGMEPTPSTVSTPSPSADLLGLR 32 1 O95782-2;O95782 O95782-2 AP2A1 AP-2 complex subunit alpha-1 1 RDPSSNDINGGMEPTPS(0.001)T(0.001)VS(0.004)T(0.012)PS(0.415)PS(0.566)ADLLGLR 77.358 9.9557e-06 5778000.0 13810.0 14538.0 20095.0 17848.0 15281.0 14324.0 14002.0 11644.0 11416.0 15227.0 True False 13042.495485810172 15653.017852962215 18802.109577781706 15417.071610482684 13361.264166126713 16297.000979674298 14653.120744436645 11677.882112232024 13699.518989690996 14787.356945502721 0.8820031553899013 1.0585406107832385 1.2714990006040257 1.0425846665702811 0.9035599948907891 1.102090186889734 0.9909222316360665 0.7897207158297223 0.9264345913998804 1.0 13.852076591393493 -7.533096353592424 23.041246952792342 0.8929107256260665 1.0479179068950029 0.231388880522034 0.11165638297233246 114.6523022131036 258537.13264722712 0.054236898625688014 0.03137538078759551 2.930243062528506e-08 7.533096353592424 0.1550071812689363 RDQALTEEHAR ddPTM_A459_Selumetinib_30min_R1 6 RDQALTEEHAR 11 1 P12814-4;P12814-3;P12814;P12814-2;H9KV75;H0YJ11 P12814-4 ACTN1 Alpha-actinin-1 0 ;;;;; 173.19 0.00019731 71757010.0 12285.099999999999 14615.11 16951.35 17278.02 16872.030000000002 13476.34 13646.51 13624.41 8551.43 11928.05 False True 12571.318927356637 12903.966126819692 14649.449777100437 14260.738155604211 15345.957865498833 13340.780255137714 12617.142763831775 13263.046388479243 14511.152138264199 13459.131406546036 0.9340364208972951 0.9587517750620719 1.088439464226902 1.0595585795877067 1.1401893184604106 0.9912066278399838 0.9374410861086662 0.9854310793063938 1.0781640880039627 1.0 13.71629768727606 -5.096202556675844 6.305147012112362 1.033958038509632 0.939862705456196 0.288768304803504 0.056186547183287014 0.29809076928617545 15.949605824146266 0.01581574889788257 0.043524249329365466 8.013042447284368e-06 5.096202556675844 -0.09409533305343609 RDQALTEEHAR ddPTM_A459_Selumetinib_30min_R2 4 RDQALTEEHAR 11 1 P12814-4;P12814-3;P12814;P12814-2;H9KV75;H0YJ11 P12814-4 ACTN1 Alpha-actinin-1 0 ;;; 187.78 2.6211e-05 82268300.0 76406.8 63868.0 71503.5 81753.6 88493.5 61579.4 69843.2 72898.6 56236.0 77883.7 False True 72160.41593665461 68766.47023201216 66903.04265712445 70618.61864717389 77376.1553880724 70061.40338786333 73091.0471916753 73110.72285698706 67484.7713651246 75634.99521484527 0.9540612216828872 0.9091885315346064 0.8845514231485406 0.9336765137166718 1.0230205630116227 0.9263093517603875 0.9663654632892651 0.9666256029938539 0.8922426870449384 1.0 16.20676628253034 -6.005902105602685 24.759074559253957 0.9608949319347817 0.9142349935967565 0.24347870088625811 0.03722038467165183 335.2840144504533 1406515.1560804546 0.010398658106560718 0.014868759054950803 9.86501828125733e-07 6.005902105602685 -0.046659938338025175 RDQDNMQAELNR ddPTM_A459_Selumetinib_30min_R1 3 RDQDNMQAELNR 12 1 P33176 P33176 KIF5B Kinesin-1 heavy chain 0 ;; 142.89 0.0043273 18979500.0 5619.96 3516.6400000000003 4717.51 4856.83 5205.4 4290.26 4502.53 4709.59 3477.81 4431.92 False True 5750.8941334614465 3104.9101539584162 4076.8980534275497 4008.6758144905007 4734.572489088016 4247.103879644408 4162.900537092302 4584.676374295694 5901.589560807565 5000.800102556537 1.1499948039357626 0.6208826768282752 0.8152491540990281 0.8016068893537982 0.9467629963188452 0.8492848729292698 0.8324468988400717 0.9167885698834252 1.1801290673047542 1.0 12.287943221878292 -8.083341206372246 4.855123200572107 1.0864776354838637 0.8505627573318975 0.3220949243706671 0.13123690486505138 0.24219871329448808 9.755575093147055 0.08837350079711 0.03216592162970512 8.25389222194257e-09 8.083341206372246 -0.2359148781519662 RDQS(ph)TSMS(ph)HINLLFS(ph)RR ddPTM_A459_Selumetinib_30min_R1 1 RDQSTSMSHINLLFSRR 17 2 Q5VUB5 Q5VUB5 FAM171A1 Protein FAM171A1 3 RDQS(0.701)T(0.245)S(0.054)MS(0.999)HINLLFS(1)RR 65.528 0.029029000000000006 16687000.0 1600.8 1935.3 1917.3 2255.4 1815.7 1980.6 1599.8 1431.4 1124.3 1135.8 True False 1638.0955253854272 1708.714176303438 1656.9411909750359 1861.5367291014668 1651.4702555878707 1960.6769622409167 1479.1257979936302 1393.4346221575236 1907.8549843769335 1281.5909936288833 1.2781734059686898 1.3332757367973818 1.2928783045543504 1.4525201396979552 1.2886094423242296 1.5298772946969381 1.1541324848151577 1.0872693621324148 1.4886613544113283 1.0 10.323720199028369 -13.314868944889737 0.2571693040723674 1.943288418908024e-12 1.3489870446043088 0.336248994136775 0.13364704656777593 112.12602820242108 1.9468064908232143 59.05175739083586 0.1843277861515109 4.8431849616880825e-14 13.314868944889737 1.3489870446023655 RDS(ph)APTENR ddPTM_A459_Selumetinib_30min_R2 2 RDSAPTENR 9 1 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 RDS(0.996)APT(0.004)ENR;RDS(1)APTENR 91.093 0.014208000000000004 7746800.0 28543.0 11864.0 13741.7 19072.3 18254.9 11241.5 28396.0 61229.0 23623.9 20940.2 True False 26956.694326682078 12773.930651227392 12857.573982831702 16474.619838447372 15961.556261123382 12789.91458482328 29716.47026560653 61407.16625299336 28349.34010691672 20335.602016826433 1.3255911629455133 0.6281560113468865 0.6322691588964451 0.810136814480125 0.7849069945367831 0.6289420187433069 1.4613027065054685 3.019687649383716 1.394074298044357 1.0 14.311720080643763 -7.489662685502144 6.140526226694944 1.9701058569237686 0.801568021499989 0.4239221925218747 0.5238069072716859 0.14495736887303798 17.022195013092134 0.21654276308540668 0.1393555545681676 3.2384508824333586e-08 7.489662685502144 -1.1685378354237796 RDS(ph)DGVDGFEAEGK ddPTM_A459_Selumetinib_30min_R1 4 RDSDGVDGFEAEGK 14 1 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 1 RDS(1)DGVDGFEAEGK;RDS(1)DGVDGFEAEGK;RDS(1)DGVDGFEAEGK;RDS(1)DGVDGFEAEGK 204.78 1.0182e-05 51246500.0 14464.599999999999 19296.2 16664.4 17710.2 15213.599999999999 14957.800000000001 16428.399999999998 16103.3 8648.4 14598.699999999999 True False 14801.59703678788 17036.991933440004 14401.466010996912 14617.44603162756 13837.532566179243 14807.338112595773 15189.192561419282 15676.188173109733 14675.703145855612 16472.585348379973 0.8985594382270765 1.0342633881156693 0.8742687141343755 0.8873801970050281 0.8400340489078189 0.8989079612844154 0.9220891705935579 0.951653176570212 0.8909168072575154 1.0 14.007779381278723 -10.678830160219677 8.559506689649167 1.0000000044045128 0.911847510673473 0.22470848869513382 0.049623701511281544 5.1772743636781995e-09 5.23715771637417e-10 0.05013869211214545 0.012160418305106124 2.0949315617068082e-11 10.678830160219677 -0.08815249373103973 RDS(ph)DGVDGFEAEGK ddPTM_A459_Selumetinib_30min_R2 4 RDSDGVDGFEAEGK 14 1 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 1 RDS(1)DGVDGFEAEGK;RDS(1)DGVDGFEAEGK;RDS(1)DGVDGFEAEGK;RDS(1)DGVDGFEAEGK 181.94 3.8718e-05 132285000.0 142720.0 101656.0 117173.0 129693.0 131778.0 117659.0 125267.0 126781.0 117303.0 114245.0 True False 134788.19375342713 109452.68832444111 109634.21674831634 112028.5896670958 115222.86952973278 133865.45924794054 131092.16371185158 127149.91172027549 140766.87771966768 110946.45000584211 1.2148941561116158 0.9865361921780973 0.988172372730658 1.0097537114634736 1.038544897323578 1.2065772202796177 1.1815805165911 1.1460475906491838 1.2687821711488318 1.0 16.75950398026913 -6.75179709101182 24.639903294801556 1.171036912356302 1.0387869794955993 0.2845252338269444 0.08829225658891451 187.82401395048385 479964.20142757136 0.028252360847854218 0.027897419671510926 1.770936173377295e-07 6.75179709101182 -0.13224993286070275 RDS(ph)ELGPGVK ddPTM_A459_Selumetinib_30min_R1 1 RDSELGPGVK 10 1 O95466;O95466-2;O95466-3;K7EK60;A0A0A0MR62 O95466 FMNL1 Formin-like protein 1 1 RDS(1)ELGPGVK 121.21 0.008706499999999999 32501000.0 2801.7 2837.0 3374.7 3133.8 2789.3 2339.6 2765.2 2593.2 1526.3 2217.2 True False 2866.974158840798 2504.842721114482 2916.434275900201 2586.540658711615 2537.0083074909135 2316.065748186835 2556.6187377247084 2524.4199120992666 2590.0196234586083 2501.7992173568914 1.1459649275411108 1.0012165259851693 1.1657347462844618 1.0338721991624298 1.0140735075339977 0.9257600418604813 1.0219120383392448 1.009041770652672 1.0352627842752786 1.0 11.28875029489048 -5.988771593008645 24.013518678495892 1.0010368095728492 1.0949643852324924 0.46859109950830535 0.048894840811983586 126.00223871464173 269468.78513705614 0.013346515487723698 0.019773114197975884 1.0261914856853616e-06 5.988771593008645 0.09392757565964316 RDS(ph)ELGPGVK ddPTM_A459_Selumetinib_30min_R2 4 RDSELGPGVK 10 1 O95466;O95466-2;O95466-3;K7EK60;A0A0A0MR62 O95466 FMNL1 Formin-like protein 1 1 RDS(1)ELGPGVK;RDS(1)ELGPGVK;RDS(1)ELGPGVK;RDS(1)ELGPGVK 111.88 0.0044051 56991900.0 376887.0 263699.0 384352.0 421267.0 389696.0 329922.0 368324.0 390440.0 268202.0 362845.0 True False 355941.12933820003 283923.8653740741 359623.210770816 363889.7078738903 340738.90455355775 375365.76076627406 385451.7958201601 391576.11575917853 321849.89419000596 352368.72206547146 1.0101382644060695 0.8057578541869558 1.0205877770955978 1.032695824251615 0.966995318302534 1.0652641317481342 1.0938876571131695 1.1112680872010603 0.9133895094417744 1.0 18.42672634386055 -5.417099095136223 9.296347752956134 1.03235551613482 0.9081738344484398 0.29828884958927193 0.07173380896671262 0.39201361716195465 31.823575525619116 0.018231436499448583 0.038010145902015464 3.827374022522522e-06 5.417099095136223 -0.12418168168638011 RDS(ph)FDDR ddPTM_A459_Selumetinib_30min_R2 1 RDSFDDR 7 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 RDS(1)FDDR 61.593 0.047247 14271000.0 35875.0 21022.0 28174.0 32168.0 34842.0 23137.0 38611.0 59890.0 43752.0 37516.0 True False 33881.2111190036 22634.319803616167 26361.315513531834 27786.662907104823 30464.83646856794 26323.91173322566 40406.48800624505 60064.2699846768 52503.62253302037 36432.8156017259 0.929964115027074 0.6212618879377505 0.7235596557155204 0.7626822810199854 0.83619220654263 0.7225330048874575 1.1090684960492294 1.6486310210356463 1.4411080139118635 1.0 15.152950873331246 -7.473899298586298 3.776438707194404 1.4093010216362378 0.7633690060729367 0.7137840052866631 0.1698460876072326 0.10840892240748402 3.166841396080441 0.0760195730238516 0.04660944512974889 3.358154719497301e-08 7.473899298586298 -0.6459320155633012 RDS(ph)FDDRGPSLNPVLDYDHGSR ddPTM_A459_Selumetinib_30min_R1 2 RDSFDDRGPSLNPVLDYDHGSR 22 2 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 RDS(0.998)FDDRGPS(0.002)LNPVLDYDHGSR;RDS(0.736)FDDRGPS(0.264)LNPVLDYDHGSR 121.0 1.2803e-05 45900000.0 11388.3 13317.1 12203.099999999999 14266.0 24462.3 12601.2 21868.0 12468.9 4267.2 6585.799999999999 True False 11653.62523222567 11757.927741048172 10545.98604683015 11774.710905986309 22249.68928416985 12474.44336897416 20218.479153972192 12138.184267304709 7241.126736043094 7431.151581124399 1.568212558310158 1.5822484056056751 1.4191590538426953 1.5845068933723312 2.9941105414516755 1.6786689428674884 2.720773346264181 1.6334190111444469 0.9744286140570756 1.0 12.8593700824571 -6.030779372826845 24.999389285484877 1.9370763133943076 1.5245639343806876 0.03820533784367386 0.6092314851176448 1720.080412274605 1397068.2646056365 0.1797355049347851 0.232332736529238 9.315810103931416e-07 6.030779372826845 -0.41251237901362003 RDS(ph)FDDRGPSLNPVLDYDHGSR ddPTM_A459_Selumetinib_30min_R2 2 RDSFDDRGPSLNPVLDYDHGSR 22 2 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 RDS(0.811)FDDRGPS(0.189)LNPVLDYDHGSR;RDS(0.717)FDDRGPS(0.283)LNPVLDYDHGSR 54.668 0.010967 108572100.0 183811.2 170099.4 308497.0 319771.0 340737.0 222891.0 175397.2 228111.2 249176.8 348943.0 True False 173595.70935853367 183145.47702422357 288648.6388861368 276217.63816425746 297930.5718325713 253592.21204695525 183553.51734295828 228774.96582615766 299019.1225815032 338868.1089272052 0.5122810461807873 0.5404624164959897 0.851802312704922 0.8151184218506494 0.8791933025971824 0.7483507753201741 0.5416665437301118 0.6751150663023959 0.8824056165336518 1.0 18.37036434478639 -14.52287728349752 0.03783997798007422 2.1665231032403742 2.369747241138402e-07 0.35365243346872866 0.12975099356867728 1388.718404187931 3.917967934991923 196.11200125933735 62.67085748648837 3.000010097654969e-15 14.52287728349752 -2.16652286626565 RDS(ph)FDNCSLGESSK ddPTM_A459_Selumetinib_30min_R1 1 RDSFDNCSLGESSK 14 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 RDS(1)FDNCSLGESSK 209.23 9.6085e-06 21037000.0 2379.9 3170.0 3017.8 3882.8 3275.2 2493.8 2673.8 2577.7 840.72 2020.8 True False 2435.3470395207255 2798.8549263069813 2607.999335588831 3204.7418691829266 2978.958738283526 2468.714636189234 2472.1131133112704 2509.3310224503634 1426.6404362406624 2280.1893642588884 1.0680459604337584 1.2274660035600466 1.1437643629376755 1.4054718083576967 1.3064523433788373 1.0826796558590301 1.0841700922128288 1.1004923809325595 0.6256675250760815 1.0 11.154937926391058 -7.824628190537984 1.5536010171421284 0.8340232242766613 1.2158457781260148 0.5180476622793254 0.13718094231706154 0.3163460766006436 1.415821290951465 0.1113972964155298 0.04149671983549987 1.4975171662271555e-08 7.824628190537984 0.3818225538493535 RDS(ph)FDNCSLGESSK ddPTM_A459_Selumetinib_30min_R2 3 RDSFDNCSLGESSK 14 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 RDS(0.812)FDNCS(0.186)LGES(0.001)SK;RDS(0.999)FDNCS(0.001)LGESSK;RDS(0.805)FDNCS(0.194)LGES(0.001)SK 209.23 9.6085e-06 33091000.0 133943.0 136674.0 171667.0 162219.0 154089.0 98746.0 111473.0 124520.0 99996.0 183963.0 True False 126498.98427631232 147156.4563238242 160622.1321168977 140124.49235661607 134730.96224686204 112347.3651730604 116656.71537955898 124882.33258460432 119997.99412168365 178651.51019672435 0.7080767698913732 0.823706758267988 0.8990807407114926 0.7843454119269198 0.7541551823351582 0.6288632267891141 0.6529847704679405 0.699027578591911 0.671687544032213 1.0 17.44678858396098 -4.464846837178676 13.43826496521425 0.7556425293259013 0.42162642067126593 0.014733199254337026 0.11072904004899464 2160630.7075148486 16739513.939183602 0.028456059457316038 18510733.183047365 3.4288869192746425e-05 4.464846837178676 -0.3340161086546353 RDS(ph)FIGTPYWMAPEVVMCETSK ddPTM_A459_Selumetinib_30min_R1 5 RDSFIGTPYWMAPEVVMCETSK 22 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 RDS(0.463)FIGT(0.453)PY(0.084)WMAPEVVMCETSK;RDS(0.95)FIGT(0.03)PY(0.02)WMAPEVVMCETSK;RDS(0.893)FIGT(0.087)PY(0.02)WMAPEVVMCETSK;RDS(0.998)FIGT(0.002)PYWMAPEVVMCETSK;RDS(0.995)FIGT(0.005)PYWMAPEVVMCETSK 165.34 6.6579999999999985e-12 650212000.0 11708.49 10944.18 14720.05 14289.529999999999 12510.21 11710.300000000001 11411.74 12252.3 7582.52 10201.16 True False 11981.275036244386 9662.830317788752 12721.148061446873 11794.13183319911 11378.663714356968 11592.505014101684 10550.943264155423 11927.329202920664 12866.982634650707 11510.578253712994 1.0408925400754352 0.8394739260533493 1.1051701991898957 1.0246341733000814 0.9885397122152856 1.007117519084001 0.9166301667556954 1.0362059090361717 1.11783981230484 1.0 13.490672691108987 -7.991167626244318 24.639251272452395 1.0649542422498919 0.9887552189280295 0.13893586147747317 0.07238655429179827 270.2945092549957 754027.3745364778 0.03857856299404367 0.018488054520057192 1.0205455039642967e-08 7.991167626244318 -0.07619902332186235 RDS(ph)FIGTPYWMAPEVVMCETSK ddPTM_A459_Selumetinib_30min_R2 3 RDSFIGTPYWMAPEVVMCETSK 22 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 RDS(0.856)FIGT(0.127)PY(0.018)WMAPEVVMCETSK;RDS(0.745)FIGT(0.14)PY(0.115)WMAPEVVMCETSK;RDS(0.796)FIGT(0.108)PY(0.095)WMAPEVVMCETSK 75.695 0.0012783 95930600.0 52622.5 45550.1 44707.2 67710.0 60272.0 33422.2 44835.2 55219.8 39127.0 47939.9 True False 49697.952114557964 49043.646203343975 41830.7874255189 58487.78119373497 52700.09252148346 38025.80467347601 46920.12563926337 55380.48047586999 46953.49329972318 46555.750524181145 1.067493307593543 1.0534390628687345 0.8985095708808714 1.2562955281615813 1.1319781536785865 0.8167799733724694 1.0078266403393705 1.189551878174647 1.0085433651281264 1.0 15.506671758726101 RDS(ph)GDNSAPSGQER ddPTM_A459_Selumetinib_30min_R1 1 RDSGDNSAPSGQER 14 1 Q8IXQ3 Q8IXQ3 C9orf40 Uncharacterized protein C9orf40 1 RDS(0.988)GDNS(0.011)APS(0.001)GQER 96.489 0.021119 278720.0 147.51 0.0 0.0 0.0 76.524 0.0 0.0 73.722 70.781 0.0 True False 150.9466959955049 0.0 0.0 0.0 69.60241771140953 0.0 0.0 71.76665307719503 120.11018736029862 0.0 0.0 RDS(ph)GDNSAPSGQER ddPTM_A459_Selumetinib_30min_R2 2 RDSGDNSAPSGQER 14 1 Q8IXQ3 Q8IXQ3 C9orf40 Uncharacterized protein C9orf40 1 RDS(0.999)GDNS(0.001)APSGQER;RDS(1)GDNSAPSGQER 193.54 0.00020849 6042200.0 8237.9 4571.2 5703.0 6836.2 7809.7 5083.8 8223.9 8039.0 5556.2 6547.1 True False 7780.070496926544 4921.796341275341 5336.07518895691 5905.09776689723 6828.575666396164 5784.0473038584305 8606.327645348696 8062.3921590719065 6667.595253199116 6358.068211591307 1.2236531974826574 0.7741024753874898 0.8392604500890356 0.9287565924712363 1.0740016368410583 0.9097177179247012 1.3536073157659143 1.2680568831226866 1.0486825606940666 1.0 12.63437277896066 -7.241451891296876 24.900768787407436 1.1899247736192042 0.9483907757768573 0.3135280736244026 0.14987723136847034 826.3002391175 1029420.9122688813 0.05692900774088732 0.04403600534854067 5.7351939428412e-08 7.241451891296876 -0.24153399784234697 RDS(ph)IVAELDR ddPTM_A459_Selumetinib_30min_R2 2 RDSIVAELDR 10 1 M0QXB4;O14579-3;O14579 M0QXB4 COPE Coatomer subunit epsilon 1 RDS(1)IVAELDR;RDS(1)IVAELDR 98.0 0.010283 4447600.0 11331.7 11819.0 12021.6 12615.8 14910.3 9046.3 12391.8 9156.2 9018.0 11719.0 True False 10701.929478389215 12725.479295925194 11248.14334412842 10897.506276531118 13037.134814226758 10292.345710864807 12968.043253885866 9182.843026109485 10821.851983972792 11380.642020381327 0.9403625436265703 1.1181688408382786 0.9883575394063343 0.9575475844873275 1.1455535452990135 0.9043730303116894 1.139482573185388 0.8068826881351813 0.9508999549051969 1.0 13.474294326780381 -7.764533847852866 24.99999845909103 0.909168525876162 1.0267514379611908 0.22424327730604554 0.09183489990309299 107.88311998503332 871548.5519488952 0.04396216732289677 0.022516604521476205 1.7197533026363027e-08 7.764533847852866 0.1175829120850288 RDS(ph)LEEGELR ddPTM_A459_Selumetinib_30min_R1 2 RDSLEEGELR 10 1 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;A0A087X1I0;A0A087WYI9;E7ESP2;J3KS35;E9PFJ2;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 RDS(1)LEEGELR;RDS(1)LEEGELR 135.02 0.0036111 61710000.0 3912.2 5236.1 3236.6000000000004 3181.7 3936.6000000000004 3502.3999999999996 4183.3 3960.8999999999996 2012.2800000000002 3941.7000000000003 True False 4003.346648183952 4623.054977803151 2797.0874973711984 2626.0758229059757 3580.535225063178 3467.1690359247636 3867.750313005849 3855.8440651835517 3414.692188883764 4447.655590409373 0.9001026646075071 1.0394363690776771 0.6288903087286369 0.590440462289542 0.8050387788083243 0.7795498022376407 0.8696155163961002 0.866938544769077 0.7677510363542938 1.0 12.118829360213141 -11.146379571368723 9.038544119252425 1.000077639913161 0.8036235362386293 0.18405154440171978 0.12293362181900591 0.00020873047987669796 8.69452265914398e-06 0.12917719526172147 0.0313177716742888 7.138721324017457e-12 11.146379571368723 -0.19645410367453175 RDS(ph)LEEGELR ddPTM_A459_Selumetinib_30min_R2 2 RDSLEEGELR 10 1 P21127;P21127-9;A0A0D9SEN2;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-3;P21127-2;P21127-6;A0A087X1I0;A0A087WYI9;E7ESP2;J3KS35;E9PFJ2;Q5QPR4;Q5QPR3;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 RDS(1)LEEGELR;RDS(1)LEEGELR 112.08 0.0043403 96334000.0 49625.0 38604.0 55030.0 53096.0 55136.0 52002.0 53608.0 54151.0 47782.0 46323.0 True False 46867.041164614726 41564.80266857573 51489.42971213374 45864.23320429114 48209.32275790604 59164.803472844396 56100.87822223678 54308.57044481935 57339.73514062856 44985.53462839186 1.0418247010236794 0.9239592907348222 1.1445774766815164 1.0195329139279519 1.071662772403277 1.31519618387515 1.2470870622226562 1.207245193225811 1.27462606845267 1.0 15.45717354821798 -6.624563798508946 6.2869598129869 1.2234967417571947 1.0343533840147727 0.4505464362653372 0.09303875989217124 0.17669017741288004 9.433577389892832 0.029437813783392493 0.029391787011728465 2.3737566887129198e-07 6.624563798508946 -0.18914335774242197 RDS(ph)LGAYASQDANEQGQDLGK ddPTM_A459_Selumetinib_30min_R1 2 RDSLGAYASQDANEQGQDLGK 21 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.994)LGAY(0.006)ASQDANEQGQDLGK;RDS(1)LGAYASQDANEQGQDLGK 193.98 8.9828e-17 55942000.0 6194.9 7792.5 3721.8 4633.4 4135.7 5028.6 5254.0 4971.2 2848.1000000000004 5058.700000000001 True False 6339.2291168229485 6880.1504773650295 3216.400002384023 3824.2636696899585 3761.626665217139 4978.01684960349 4857.686549980334 4839.347627266652 4833.017683006267 5708.033420910747 1.110580238300618 1.2053451635655044 0.5634865399703335 0.6699792008365251 0.659005718403266 0.8721071659053499 0.851026297811211 0.8478134710175731 0.8467045174089282 1.0 12.478778066574755 -5.244647389604571 24.82293390865353 0.7796535903845192 1.1579627784663473 0.5931454534803505 0.12212235008926539 513.6684532262216 759332.5157111342 0.03239967378485102 0.08521050433217536 5.693149788681479e-06 5.244647389604571 0.3783091880818281 RDS(ph)LGAYASQDANEQGQDLGK ddPTM_A459_Selumetinib_30min_R2 4 RDSLGAYASQDANEQGQDLGK 21 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.973)LGAY(0.027)ASQDANEQGQDLGK;RDS(0.997)LGAY(0.003)ASQDANEQGQDLGK;RDS(0.97)LGAY(0.03)ASQDANEQGQDLGK;RDS(0.991)LGAY(0.009)ASQDANEQGQDLGK 164.89 4.3089e-09 164118000.0 448497.0 396552.0 456402.0 472182.0 501733.0 433568.0 495049.0 468560.0 402217.0 452749.0 True False 423571.33221574215 426966.2632843503 427037.5922129243 407869.9970406169 438700.8149900699 493288.05646156333 518069.7594209834 469923.43202571676 482671.6388819687 439676.95998682716 0.9633694070037977 0.9710908283598538 0.9712530586677057 0.9276583359128865 0.9977798586562586 1.121932922016979 1.178296355207025 1.0687924881026192 1.097786972727499 1.0 18.746084408662043 -6.646604706100079 4.415987328379074 1.1026789709339078 0.9605121608088122 0.6795322457423774 0.043965162511562676 0.11953580314767502 4.051340026697564 0.014730102598438051 0.014632323410241415 2.2562919498741307e-07 6.646604706100079 -0.14216681012509558 RDS(ph)LGAYASQDANEQGQDLGKR ddPTM_A459_Selumetinib_30min_R1 2 RDSLGAYASQDANEQGQDLGKR 22 2 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.998)LGAY(0.002)ASQDANEQGQDLGKR;RDS(1)LGAYASQDANEQGQDLGKR 132.39 1.1365e-05 106868000.0 5025.1 5700.4 5645.5 6418.4 6216.0 5888.2 5827.6 5570.900000000001 2836.41 4806.4 True False 5142.175052857512 5032.994517955938 4878.872108511741 5297.5469282898175 5653.763897523938 5828.970054057841 5388.019440172325 5423.14163516652 4813.180606810088 5423.348258300632 0.9481550525521252 0.9280234789002821 0.899605165691591 0.976803752217411 1.0424858644972037 1.0747917663477335 0.9934857920890042 0.9999619011864497 0.8874924451778179 1.0 12.404968100117777 -5.942950505177157 5.633247851458657 1.0037490735517147 0.9263357168649582 0.33852806560461435 0.04627661453755597 0.2287254679641216 15.030653269397133 0.013979196323706191 0.020851435126355893 1.1403797447207146e-06 5.942950505177157 -0.07741335668675653 RDS(ph)LGAYASQDANEQGQDLGKR ddPTM_A459_Selumetinib_30min_R2 1 RDSLGAYASQDANEQGQDLGKR 22 2 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.974)LGAY(0.026)ASQDANEQGQDLGKR 56.553 0.0090527 3099000.0 11176.0 11264.0 21729.0 17230.0 21732.0 14222.0 13832.0 12664.0 9373.1 20192.0 True False 10554.882661072737 12127.912580531462 20330.979796746393 14883.244276592137 19001.831873454987 16180.9514055381 14475.215407588028 12700.850143361933 11247.981906295785 19609.0044948835 0.5382671345619193 0.6184869090981111 1.0368185596597357 0.7590005030839564 0.9690360302795107 0.8251796469198696 0.73819226322096 0.6477049942375156 0.5736131025535068 1.0 14.259228674551682 -5.021040983457349 23.69230111622456 0.8081018333829607 0.5583218834115102 0.31644819198587215 0.1427376289429408 415.1344580387087 467450.68336649047 0.03749959678287013 0.10194631388434738 9.527062548948123e-06 5.021040983457349 -0.24977994997145048 RDS(ph)LGNEESVDK ddPTM_A459_Selumetinib_30min_R2 1 RDSLGNEESVDK 12 1 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 RDS(1)LGNEESVDK 105.17 0.004843500000000001 4197500.0 60474.0 36830.0 48448.0 54689.0 56010.0 47780.0 59999.0 54835.0 42339.0 56117.0 True False 57113.09717660279 39654.74257288475 45330.90842619403 47240.263856212885 48973.523064246896 54361.261296344455 62789.07238576301 54994.560771577075 50807.98305050169 54496.7564005238 1.0480091100624447 0.7276532621766019 0.8318092932547143 0.8668454230380366 0.8986502371685405 0.9975137033260563 1.152161642874575 1.0091345688061628 0.9323120568330437 1.0 15.733882744042008 -6.722264875045219 3.0664019608113815 1.030037506113139 0.8584367651312635 0.39389720681623686 0.08940247654165535 0.241753886755583 4.657403338199682 0.0322943456182984 0.03074359323288519 1.8955494780244661e-07 6.722264875045219 -0.1716007409818755 RDS(ph)LGTYSSR ddPTM_A459_Selumetinib_30min_R1 2 RDSLGTYSSR 10 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.996)LGT(0.002)YS(0.001)S(0.001)R;RDS(0.999)LGTYSSR 86.699 0.01781 129024000.0 2523.1 3603.0 2491.8 2443.4 2292.3 2320.3 2428.3999999999996 2442.3999999999996 1530.33 1989.05 True False 2581.883320902031 3181.159085010744 2153.427246477648 2016.7060582985391 2084.961869738436 2296.959888663839 2245.2238328839444 2377.6196179667018 2596.8582391190544 2244.3639424876988 1.1503853149771328 1.417398945326435 0.9594821970320667 0.898564631217155 0.9289767271111216 1.0234346779416899 1.000383133225395 1.059373470120581 1.1570575475565 1.0 11.13209092471244 -5.273283858587422 24.990875857222104 0.9997339128791177 1.283892133186039 0.6071353921586842 0.09021085785769244 424.9784938915979 896670.1116918351 0.024225477476882588 0.05106252239691544 5.329864171355167e-06 5.273283858587422 0.28415822030692117 RDS(ph)LGTYSSR ddPTM_A459_Selumetinib_30min_R2 4 RDSLGTYSSR 10 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.857)LGT(0.025)YS(0.117)SR;RDS(0.998)LGT(0.001)YS(0.001)SR;RDS(0.983)LGT(0.002)YS(0.006)S(0.009)R;RDS(1)LGTYSSR 119.21 0.0028083 222814000.0 113071.0 106871.0 138731.0 146564.0 153897.0 126131.0 121316.0 118266.0 111853.0 129915.0 True False 106786.96647907616 115067.66205557343 129805.198498892 126601.73036299778 134563.08300336392 143504.4003467814 126957.4343830935 118610.13448000967 134226.72543394397 126164.01639029244 0.8464138153998463 0.9120481841637628 1.0288607022253908 1.0034694042344947 1.0665726001230706 1.13744318271262 1.0062887819800108 0.9401264946503083 1.0639065660267923 1.0 16.944940968134787 -5.08405455186498 2.0505261438649387 1.033980909405302 0.8369437973438998 0.6122044700366782 0.04950528285234717 0.29655490876963786 2.05790964380785 0.014707192907690035 0.08635104658723876 8.240346012693214e-06 5.08405455186498 -0.1970371120614023 RDS(ph)LTGSSDLYK ddPTM_A459_Selumetinib_30min_R1 3 RDSLTGSSDLYK 12 1 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;E9PR38;Q14671-4;H0YDK8 Q5T1Z4 PUM1 Pumilio homolog 1 1 RDS(0.854)LT(0.125)GS(0.019)S(0.002)DLYK;RDS(0.986)LT(0.014)GSSDLYK;RDS(0.995)LT(0.004)GS(0.001)S(0.001)DLYK 113.52 0.0030403 43707400.0 12228.800000000001 16383.599999999999 12181.1 13665.0 15195.0 12718.3 15364.599999999999 14021.5 6582.1 11910.8 True False 12513.707246897362 14465.400495470996 10526.973525992802 11278.664273819075 13820.614932895141 12590.365449292452 14205.63585188958 13649.604271749153 11169.342962436549 13439.66720101681 0.9311024640513872 1.0763213314074163 0.7832763541344505 0.8392071102003003 1.028345027163285 0.936806340587057 1.056993126348755 1.01562070456004 0.8310728826374143 1.0 13.714209793455767 -6.273922815579324 24.710401643119965 0.9807967173086487 0.9106656713468768 0.12514555751733036 0.09121097593147673 1534.7370608059648 3037936.556325478 0.02930062893134862 0.0334576961336389 5.322028359175552e-07 6.273922815579324 -0.07013104596177189 RDS(ph)LTGSSDLYK ddPTM_A459_Selumetinib_30min_R2 4 RDSLTGSSDLYK 12 1 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;E9PR38;Q14671-4;H0YDK8 Q5T1Z4 PUM1 Pumilio homolog 1 1 RDS(0.999)LT(0.001)GSSDLYK;RDS(0.982)LT(0.017)GSS(0.001)DLYK;RDS(0.994)LT(0.004)GS(0.001)S(0.001)DLYK;RDS(1)LTGSSDLYK 169.15 0.00018453 138278000.0 602759.0 433975.0 537634.0 594360.0 550591.0 475885.0 486321.0 494834.0 413314.0 508957.0 True False 569260.0678154557 467259.48705043946 503043.21377164044 513407.14267181157 481420.83623400726 541433.8390960837 508935.89012678026 496273.8850158211 495988.3489580538 494262.0889809045 1.1517372675480453 0.9453678472768559 1.0177661305337848 1.0387346189758988 0.9740193451345338 1.0954387382055548 1.0296882999384618 1.0040703021327504 1.003492600415113 1.0 18.914916727188483 -6.699965081675709 0.005029314506365725 2.6192638444516407e-07 2.050297558171985 0.06729265511708782 0.05441155276998163 39413.85749526481 74.32832978947141 14931.410724975569 15366.901368768622 1.99542274532295e-07 6.699965081675709 2.0502972962456005 RDS(ph)NLHSSTDKEQAER ddPTM_A459_Selumetinib_30min_R2 1 RDSNLHSSTDKEQAER 16 2 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 RDS(1)NLHSSTDKEQAER 90.707 0.0047572 2083600.0 2722.4 2286.1 4746.5 8635.1 11072.0 4504.0 2616.9 3370.8 4791.7 6639.5 True False 2571.099906630673 2461.4365190299186 4441.115357598451 7458.984483621637 9681.036375064134 5124.385116758798 2738.591035288977 3380.608469934019 5750.1738912843675 6447.800383507279 0.3987561266951202 0.3817482509734616 0.6887799084100534 1.1568262104858038 1.5014479045950453 0.7947493427163747 0.42473260219003883 0.5243041454231774 0.8918039562751728 1.0 12.654591365038213 -5.420878477916009 3.888712246856908 0.8827855333521792 0.3949750079217672 0.32959347981460363 0.2868472020076694 0.31814209355781076 8.485065831368209 0.0894468731478228 0.19827353015750038 3.794211378239736e-06 5.420878477916009 -0.48781052543041203 RDS(ph)PLQGSGQQNSQAGQR ddPTM_A459_Selumetinib_30min_R1 3 RDSPLQGSGQQNSQAGQR 18 1 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819;O95819-6;E7EN19 G5E948;O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 RDS(1)PLQGSGQQNSQAGQR;RDS(1)PLQGSGQQNSQAGQR;RDS(1)PLQGSGQQNSQAGQR 169.7 4.8186e-08 23245600.0 4435.64 5106.9400000000005 5036.249999999999 5747.93 5568.919999999999 4308.3 4660.17 5052.43 2305.29 3861.7400000000002 True False 4538.981781747011 4509.017090648004 4352.354912141044 4744.161927509173 5065.212169272681 4264.962413623419 4308.649624975608 4918.423143794423 3911.9087582800867 4357.431945533016 1.0416644111677085 1.0347877252036912 0.9988348565266346 1.0887518122624062 1.1624305858557906 0.9787788924610994 0.9888048003578308 1.12874353639338 0.8977555604259858 1.0 12.089262417146443 -8.270852381543396 24.999762237513487 0.9488777838784928 1.0506926185962682 0.3164628553527208 0.0610558593709491 928.4530756247358 2465827.134995303 0.056642244563851044 0.015397120883163938 5.359788079263724e-09 8.270852381543396 0.10181483471777542 RDS(ph)PLQGSGQQNSQAGQR ddPTM_A459_Selumetinib_30min_R2 4 RDSPLQGSGQQNSQAGQR 18 1 G5E948;A0A0D9SEY1;O95819-3;C9J840;A0A0D9SG62;H7C0P6;O95819-2;O95819-5;E7EX83;E7ENQ1;G3XAA2;H7C360;O95819-4;O95819;O95819-6;E7EN19 G5E948;O95819-6 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 RDS(1)PLQGSGQQNSQAGQR;RDS(1)PLQGSGQQNSQAGQR;RDS(1)PLQGSGQQNSQAGQR;RDS(1)PLQGSGQQNSQAGQR 101.9 0.0012485 44014000.0 31563.0 30570.100000000002 33783.3 38173.399999999994 40196.9 26856.000000000004 37559.3 34464.8 26626.699999999997 34676.8 True False 29808.854816699968 32914.72837163576 31609.71925847588 32974.117067212 35147.00605715455 30555.170225504968 39305.88187234104 34565.08686204522 31952.78401215884 33675.59068285341 0.8851768955571054 0.9774061183251922 0.9386537434834243 0.9791696715212012 1.043693825244477 0.9073388055242854 1.167192054402609 1.0264136771220678 0.9488410853154902 1.0 15.039415630886607 -5.087156764950857 0.6141137742765682 1.0247448793081255 0.8574112831145454 0.2415244432374778 0.06636328529755811 3.849345576421744 1.4212285627035244 0.034972538088274545 0.4316833779578709 8.181694046027627e-06 5.087156764950857 -0.16733359619358013 RDS(ph)PPPPAR ddPTM_A459_Selumetinib_30min_R1 4 RDSPPPPAR 9 1 O96013;O96013-2;O96013-4;M0R2X4 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 RDS(1)PPPPAR;RDS(1)PPPPAR;RDS(1)PPPPAR;RDS(1)PPPPAR 89.35600000000002 0.01539 207335000.0 6311.1 7684.3 7772.6 8980.2 8185.0 6889.7 7715.5 7280.0 4260.74 6325.5 True False 6458.1363507371125 6784.618583665846 6717.123611835686 7411.976649231619 7444.6681951791215 6820.3958733470845 7133.513623215312 7086.91075122731 7230.164587862829 7137.439540587693 0.904825366857728 0.9505675732991503 0.9411111048490368 1.0384643690615867 1.043044659481085 0.9555801957497908 0.9994499543778891 0.9929206000172687 1.0129913601015947 1.0 12.80119090449116 -5.662983359295036 6.795415273535854 1.0048070159166076 0.9324496929265098 0.6426697414903209 0.02529129747790501 0.14746827276355343 8.733895566510766 0.007251812355786765 0.01261871320149962 2.1727844310658383e-06 5.662983359295036 -0.07235732299009778 RDS(ph)PPPPAR ddPTM_A459_Selumetinib_30min_R2 6 RDSPPPPAR 9 1 O96013;O96013-2;O96013-4;M0R2X4 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 RDS(1)PPPPAR;RDS(1)PPPPAR;RDS(1)PPPPAR;RDS(1)PPPPAR;RDS(1)PPPPAR;RDS(1)PPPPAR 105.2 0.024929 819074340.0 217829.5 209595.19999999998 203700.2 236606.2 246758.1 159640.19999999998 196714.6 217299.1 166990.80000000002 215812.9 True False 205723.40843057848 225670.47788521083 190594.35090400823 204380.02739153887 215758.14143259695 181629.1884805501 205862.2186825848 217931.4044051975 200393.6261127968 209581.82082774598 0.9815899471531994 1.0767655180870292 0.9094030682205808 0.9751801305301072 1.029469734447661 0.8666266366195474 0.9822522672507064 1.0398392548765667 0.9561593907398062 1.0 17.677154057060775 -7.535568141709923 24.93355157344767 1.001008747507587 0.9732001005007251 0.03753681054680713 0.05737127563342953 872.5452419195665 1714451.8241292802 0.02716621602426564 0.015695166193644968 2.913612946957221e-08 7.535568141709923 -0.02780864700686192 RDS(ph)PTYDPYK ddPTM_A459_Selumetinib_30min_R1 1 RDSPTYDPYK 10 1 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 RDS(0.897)PT(0.102)Y(0.001)DPYK 75.02 0.031312 19539000.0 8545.3 11079.0 10062.0 10084.0 8961.9 8224.4 9384.8 9121.7 4874.2 8201.6 True False 8744.388863740682 9781.865529512634 8695.635666609718 8323.018700123786 8151.297727351955 8141.670003157722 8676.89698025417 8879.762884542608 8271.161402517168 9254.355250349216 0.9448944445276952 1.0570012999169782 0.9396263090593573 0.8993623515597929 0.8808066587939082 0.8797663135798136 0.9376014585053611 0.9595225863203736 0.8937587955903307 1.0 13.175916765895083 -5.468675001257158 8.039046144850673 0.9172440828030725 1.0007355964159965 0.3381385760078244 0.04351993575549241 0.31794202777638453 43.16118329976649 0.011089347127154994 0.022992943045330463 3.3987952195677053e-06 5.468675001257158 0.08349151361292406 RDS(ph)PTYDPYK ddPTM_A459_Selumetinib_30min_R2 4 RDSPTYDPYK 10 1 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 RDS(0.843)PT(0.157)YDPYK;RDS(0.991)PT(0.009)YDPYK;RDS(0.962)PT(0.032)Y(0.003)DPY(0.002)K;RDS(0.97)PT(0.03)YDPYK 105.25 0.0073783999999999985 60383000.0 381630.0 363332.0 400473.0 436779.0 405687.0 343834.0 412977.0 441743.0 356484.0 380031.0 True False 360420.5323859329 391198.39610348555 374707.00318203366 377288.946714199 354720.97217220353 391194.0124857119 432181.2487984006 443028.39899550914 427790.7609951822 369058.51759088004 0.9765945377406985 1.0599901572713428 1.0153051218761335 1.0223011493598497 0.9611510241999877 1.0599782794320172 1.1710371884100377 1.2004285983899943 1.1591407340702804 1.0 18.493490061304577 -7.0861942012055446 4.208394443477843 1.14831397388053 1.0110352948747041 0.5153662919273323 0.05636611935482499 0.16576868997446628 5.291739511855836 0.021251670401991045 0.016489690647539156 8.199847939998371e-08 7.0861942012055446 -0.1372786790058258 RDS(ph)PTYDPYKR ddPTM_A459_Selumetinib_30min_R1 1 RDSPTYDPYKR 11 2 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 RDS(0.975)PT(0.024)YDPYKR 90.689 0.031055000000000006 48934000.0 2754.9 3031.7 3077.7 2869.2 2968.0 2309.3 3278.4 2946.2 1615.9 3429.7 True False 2819.083809897748 2676.7471546009074 2659.7652445959784 2368.148081554461 2699.5449240429584 2286.070538676638 3031.1076485450176 2868.057205393668 2742.0642793335305 3869.9354031070416 0.7284575881122977 0.6916774766968556 0.6872893130103779 0.6119347831111481 0.6975684715242493 0.5907257616861585 0.7832450242222242 0.7411124235022116 0.70855556842939 1.0 11.918093769792776 -9.742361605043316 0.5016239444773333 1.0409143506638054 0.6737392178080908 0.7674657383356952 0.05140744412313899 2.799188859026579 0.7436090682029324 0.2705756168394862 0.025777113271530684 1.8098325507678405e-10 9.742361605043316 -0.3671751328557147 RDS(ph)PTYDPYKR ddPTM_A459_Selumetinib_30min_R2 2 RDSPTYDPYKR 11 2 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 1 RDS(0.905)PT(0.092)Y(0.003)DPYKR;RDS(0.992)PT(0.007)Y(0.002)DPYKR 57.347 0.041941 87803000.0 209399.0 146363.0 196750.0 202777.0 213070.0 169576.0 211715.0 241401.0 192803.0 164557.0 True False 197761.44187061302 157588.57146877868 184091.31920520248 175158.42279016363 186302.2417300321 192933.55474233784 221560.16700531373 242103.43694391285 231368.98736592464 159805.81183956738 1.2375109490332563 0.9861254084237272 1.1519688619961823 1.0960704168006674 1.1658039190531135 1.20729998816331 1.386433725124734 1.5149851820593727 1.4478133473531059 1.0 17.285960351786883 -7.058632945687275 2.462235472581152 1.3805437304937378 1.1184003937121756 0.3062931863647902 0.14259248706132302 0.28790632480636974 3.4536889630262078 0.05816125848926364 0.04448209369122773 8.737094927848035e-08 7.058632945687275 -0.2621433367815622 RDS(ph)QDGSSYR ddPTM_A459_Selumetinib_30min_R1 1 RDSQDGSSYR 10 1 Q14847;Q14847-2;C9J9W2;Q14847-3;J3KSN1 Q14847 LASP1 LIM and SH3 domain protein 1 1 RDS(1)QDGSSYR 155.88 0.00093014 6088300.0 1539.8 2501.4 1428.0 1410.6 1910.4 1843.5 1819.2 2068.0 1457.1 1871.3 True False 1575.6743440707655 2208.5349251306893 1234.0854434425232 1164.2651902414332 1737.6046573085137 1824.956063764076 1681.9762793536765 2013.1499221892964 2472.5922776266384 2111.499583005571 0.7462347408223989 1.0459556529899927 0.584459240899252 0.551392574079595 0.8229244615029266 0.8642938310062934 0.7965790251113863 0.9534218895386753 1.1710124394659256 1.0 11.044052246887329 -7.888918236184792 2.4615681730967034 1.0864861799253738 0.7693118239614194 0.46396182454462964 0.1367269857534604 0.28133654146287645 3.3126251882335835 0.1047192874483754 0.04052508786780574 1.2914623919521498e-08 7.888918236184792 -0.3171743559639544 RDS(ph)QDGSSYR ddPTM_A459_Selumetinib_30min_R2 2 RDSQDGSSYR 10 1 Q14847;Q14847-2;C9J9W2;Q14847-3;J3KSN1 Q14847 LASP1 LIM and SH3 domain protein 1 1 RDS(0.999)QDGSS(0.001)YR;RDS(0.994)QDGSS(0.005)YR 102.33 0.0079075 293941000.0 16691.4 15315.8 16621.7 12182.5 20818.4 13245.400000000001 23336.0 22221.0 24153.0 19785.800000000003 True False 15763.758808968272 16490.47261194104 15552.277918338606 10523.22248401531 18203.00647314261 15069.833620230243 24421.170239406747 22285.65943111542 28984.274891205914 19214.532544317837 0.8204081349681319 0.8582291853265844 0.8094018359524318 0.5476699711400088 0.947356196730669 0.784293533317662 1.2709739455321085 1.159833546807038 1.508455895263359 1.0 14.229910258151682 -7.260415848295734 24.809886362140723 1.2481353278666913 0.7938515211483184 0.6717046038483613 0.1506680792098466 47.36292638050026 1148074.5279064677 0.05790518451452457 0.04224242619856836 5.49014925979787e-08 7.260415848295734 -0.454283806718373 RDS(ph)QGTYSSR ddPTM_A459_Selumetinib_30min_R2 1 RDSQGTYSSR 10 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(1)QGTYSSR 110.98 0.0046871000000000005 1645000.0 1117.9 883.86 968.85 1690.8 2545.0 986.49 3252.7 4780.3 3114.1 4078.1 True False 1055.7715933082688 951.6492199421648 906.5152458041212 1460.5101232073125 2225.2743474113254 1122.370043035388 3403.9569951027756 4794.209881578736 3737.0070152239614 3960.3546568237116 0.2665851128987069 0.24029393890329198 0.22889749135022305 0.368782659575916 0.5618876439707656 0.28340139717071516 0.859508122394478 1.2105506443263325 0.9436041312070571 1.0 11.951413916666466 -7.37247306764705 3.4773013746446444 1.0570168515027893 0.3275441113869121 0.8996389213549169 0.11207076709787668 0.07532164554717719 1.684740642529231 0.05371720618364572 0.03448073663240416 4.241572867994895e-08 7.37247306764705 -0.7294727401158773 down RDS(ph)SDDWEIPDGQITVGQR ddPTM_A459_Selumetinib_30min_R2 4 RDSSDDWEIPDGQITVGQR 19 1 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056;A0A2R8Y679;A0A2R8Y492;A0A2R8YDP5 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 RDS(0.954)S(0.046)DDWEIPDGQITVGQR;RDS(0.5)S(0.5)DDWEIPDGQITVGQR;RDS(0.745)S(0.243)DDWEIPDGQIT(0.012)VGQR;RDS(0.984)S(0.016)DDWEIPDGQITVGQR 169.33 2.2845e-09 48174300.0 64952.9 57894.2 60867.8 68026.7 66726.7 52187.9 53862.0 54475.6 48102.700000000004 60316.3 True False 61343.07784506003 62334.498980806515 56951.63201584984 58761.34610739709 58343.895401733316 59376.30951041219 56366.6897255282 54634.11497707891 57724.5841017352 58574.81169843208 1.0472603507610088 1.064186075436843 0.9722887767708234 1.0031845498697523 0.9960577543486163 1.0136833186268965 0.9623025339923886 0.9327236980010872 0.9854847574914246 1.0 15.837992790785963 -4.409468277321866 0.5144213488059658 0.9719374302296745 1.1596850516317494 0.49929261509574374 0.025941293932943938 5.086393454988334 0.7783262777566822 0.015889504203011225 0.6236821887538575 3.8952175895647917e-05 4.409468277321866 0.1877476214020749 RDS(ph)SDTTPLLNGSSQDR ddPTM_A459_Selumetinib_30min_R2 2 RDSSDTTPLLNGSSQDR 17 1 E9PCW1;B4DQA8 E9PCW1 GOSR1 Golgi SNAP receptor complex member 1 1 RDS(0.91)S(0.08)DT(0.008)T(0.002)PLLNGSSQDR;RDS(0.876)S(0.123)DT(0.001)TPLLNGSSQDR 124.08 0.00068025 13305600.0 28569.0 14624.7 24078.0 27861.0 24088.7 15439.5 19926.0 23220.7 21923.8 21845.0 True False 26981.24935076834 15746.36746417778 22528.84769414421 24066.28373709423 21062.462150289677 17566.150979173508 20852.59848261994 23288.268392606165 26309.17260215377 21214.278089873704 1.271843860840469 0.7422532785451726 1.0619662662430165 1.1344380249536694 0.9928436905116044 0.8280343504857904 0.9829511234970373 1.0977638877903861 1.2401634639979586 1.0 14.372747964900713 -7.850538703481977 4.740511941268734 1.1338221313867969 0.9925111308726478 0.10010289366296898 0.14908502437781335 0.4178523602592582 16.171056080022293 0.0830862445289825 0.038685666787593664 1.4107865042984262e-08 7.850538703481977 -0.14131100051414913 RDS(ph)SEGPPGSEGDGGGQSKPSNASGGVDK ddPTM_A459_Selumetinib_30min_R1 1 RDSSEGPPGSEGDGGGQSKPSNASGGVDK 29 2 E7EUC4;Q9NRH2 E7EUC4 SNRK SNF-related serine/threonine-protein kinase 1 RDS(0.5)S(0.5)EGPPGS(0.001)EGDGGGQSKPSNASGGVDK 58.47 0.0018799 3499800.0 473.56 452.97 763.59 723.9 715.06 498.63 427.12 530.14 425.07 498.81 True False 484.59302661264536 399.93606181996006 659.8986720996334 597.4844542859589 650.3829492540968 493.614234919816 394.9019945237151 516.0789650625888 721.3127441155414 562.8371223208513 0.8609827024458382 0.7105715773878402 1.172450511754715 1.0615583631410803 1.1555438038135286 0.8770108000062332 0.7016274848669221 0.9169241768107692 1.2815656883846216 1.0 9.13657367546003 -5.246514573730274 24.942339918689527 1.0075966874792561 0.78577713235479 0.25269222277147163 0.1604047491910486 1238.7090558055675 2070122.6242369562 0.04380735498658082 0.1148875557002436 5.668725485178706e-06 5.246514573730274 -0.22181955512446616 RDS(ph)SESQLASTESDKPTTGR ddPTM_A459_Selumetinib_30min_R1 5 RDSSESQLASTESDKPTTGR 20 2 A0A087WVF1;Q96B23-2;Q96B23;K7EQH1 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 RDS(0.852)S(0.147)ES(0.002)QLASTESDKPTTGR;RDS(0.709)S(0.286)ES(0.005)QLASTESDKPTTGR;RDS(0.848)S(0.144)ES(0.009)QLASTESDKPTTGR;RDS(0.949)S(0.051)ESQLASTESDKPTTGR;RDS(0.873)S(0.126)ES(0.001)QLASTESDKPTTGR 156.0 1.9609e-06 160936000.0 4722.38 5085.48 6079.370000000001 6603.21 5639.99 5196.99 5271.8099999999995 5131.910000000001 3006.67 4467.6 True False 4832.402265848094 4490.069637424486 5253.824945589063 5450.083331103176 5129.853900321107 5144.712999089375 4874.153127341419 4995.795076007002 5102.099391511695 5041.059978109172 0.9586083654693308 0.890699507032774 1.0422063947669387 1.0811383627193862 1.0176141372246161 1.0205617511853295 0.9668905247125512 0.9910207570830869 1.01210844815725 1.0 12.299511404176176 -5.2646895902068565 24.999227599834676 1.0168516674193488 0.9246539343174595 0.560580753215767 0.03250480839400168 203.15901493949377 1562623.56724183 0.009245251797590033 0.020610323282178104 5.4363875572579205e-06 5.2646895902068565 -0.09219773310188939 RDSFDDR ddPTM_A459_Selumetinib_30min_R2 1 RDSFDDR 7 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 0 124.08 0.0091764 3205100.0 11405.0 8546.5 7172.5 9502.7 9693.8 11161.0 19124.0 30037.0 18602.0 16631.0 False True 10771.155757832366 9201.989068671179 6711.029158827539 8208.415866928159 8475.97818032845 12698.32644052952 20013.303893487107 30124.402697106947 22322.919783306923 16150.819817472622 0.6669107747818279 0.5697536826406848 0.41552250812477465 0.5082352450027309 0.5248017299504999 0.7862341716419836 1.2391509607354971 1.865193410461872 1.3821539733331103 1.0 13.979319777693634 -7.228378252802778 2.4709972610717927 1.4774873656256602 0.5360775726628364 0.7787656269061389 0.21004550283320517 0.12146341366851302 1.459218228393884 0.09380823409361104 0.06382887244880982 5.910466323946765e-08 7.228378252802778 -0.9414097929628238 RDSFDDRGPS(ph)LNPVLDYDHGSR ddPTM_A459_Selumetinib_30min_R1 1 RDSFDDRGPSLNPVLDYDHGSR 22 2 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 RDS(0.498)FDDRGPS(0.502)LNPVLDYDHGSR 97.621 7.0497e-05 42660000.0 4888.7 5033.8 5236.8 6182.2 10470.0 5837.2 8783.4 5536.8 1357.0 2652.5 True False 5002.597198245714 4444.440355849869 4525.671323683339 5102.594824266688 9522.990348628635 5778.4830677535465 8120.861066444087 5389.946077938929 2302.729888641377 2992.974212537957 1.6714468094276207 1.4849577845447288 1.5120983350690813 1.7048575971323965 3.1817816233549867 1.9306825443222102 2.713308064073772 1.8008661936877859 0.7693784593916455 1.0 11.547364133292996 -8.186325008219994 4.69599647999852 0.8847497233045202 2.028674745589037 0.4325909652614853 0.5144925119583199 0.21027584351629247 8.389463929652193 0.41288360687264486 0.1428614531546404 6.511409244576625e-09 8.186325008219994 1.1439250222845168 RDSFDDRGPS(ph)LNPVLDYDHGSR ddPTM_A459_Selumetinib_30min_R2 2 RDSFDDRGPSLNPVLDYDHGSR 22 2 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 RDS(0.023)FDDRGPS(0.977)LNPVLDYDHGSR;RDS(0.192)FDDRGPS(0.808)LNPVLDYDHGSR 109.37 2.0285e-05 40711000.0 48404.0 49457.0 108461.0 138412.0 157215.0 82096.0 54794.0 76765.0 94936.0 137016.0 True False 45713.89945656446 53250.19287068047 101482.73734340798 119560.0468259821 137464.24618006757 93403.97880671191 57342.029572251166 76988.3734408702 113925.85273347126 133059.99206967873 0.34355856140909535 0.40019687392432174 0.762684077797518 0.8985424165918544 1.0330997623093385 0.701968919085758 0.4309486922426931 0.5785989630944376 0.8561991546926622 1.0 17.021717327285465 -5.241662761801738 4.9837760258318236 0.7662972166569058 0.36246686988401594 0.46938957242860735 0.17433111084087125 0.18143893970921726 13.301245121276047 0.0502630483295351 0.1305920844105648 5.7324099109602255e-06 5.241662761801738 -0.4038303467728898 RDSFDNCS(ph)LGESSK ddPTM_A459_Selumetinib_30min_R2 1 RDSFDNCSLGESSK 14 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 RDS(0.026)FDNCS(0.971)LGES(0.003)SK 148.18 0.00083386 13763000.0 63051.0 59637.0 78433.0 75563.0 66182.0 37114.0 44829.0 52796.0 42130.0 76686.0 True False 59546.87783315115 64210.96613682128 73386.7061713936 65271.189046554435 57867.62548541309 42226.11661265232 46913.6373269783 52949.62761915171 50557.17721055378 74471.87592584382 0.7995887990312692 0.8622176538262584 0.9854284622085955 0.8764542081838912 0.7770399867868967 0.5670075593999999 0.6299510619779883 0.7110016628542684 0.6788761070138295 1.0 16.18440807864424 -6.424464456779696 3.7743015334041607 0.6920821227118833 0.8861483263831186 0.29227360731576346 0.11570280850904094 0.25234042050800226 6.534841454021191 0.036310509731896395 0.040896507364481145 3.7630114797865645e-07 6.424464456779696 0.19406620367123528 RDSFIGT(ph)PYWMAPEVVMCETSK ddPTM_A459_Selumetinib_30min_R1 1 RDSFIGTPYWMAPEVVMCETSK 22 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 RDS(0.308)FIGT(0.578)PY(0.113)WMAPEVVMCETSK 94.384 0.00034791 11698000.0 2361.7 1807.8 2046.3 2288.2 1846.5 1552.6 1724.9 2052.3 1274.4 1623.0 True False 2416.72301493176 1596.1419355765806 1768.4236995213146 1888.6088248337219 1679.484401026053 1536.9822536480085 1594.7894042750424 1997.8663371900855 2162.563721506683 1831.3278593587577 1.3196561186908278 0.8715762868017921 0.9656510659650702 1.0312783782446369 0.917085595811406 0.8392720319267055 0.8708377345569681 1.090938647047963 1.1808719615415604 1.0 10.83867438203884 -10.683368321579906 6.283040720801705 1.0000000237288784 0.995533623591638 0.0 0.1456587548889589 4.879601947796655e-08 6.3952775916592e-09 0.14192315297879318 0.03442123750268787 2.073154546347857e-11 10.683368321579906 -0.004466400137240423 RDSFIGT(ph)PYWMAPEVVMCETSK ddPTM_A459_Selumetinib_30min_R2 1 RDSFIGTPYWMAPEVVMCETSK 22 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 RDS(0.07)FIGT(0.512)PY(0.418)WMAPEVVMCETSK 65.416 0.0019929 2955200.0 7367.4 6912.5 6485.4 8098.2 8016.9 6193.1 7501.8 7519.3 5727.8 7130.9 True False 6957.949402038943 7442.666522809282 6068.136424769617 6995.211189825798 7009.745350004659 7046.14330963564 7850.648564534696 7541.179918112876 6873.520048103728 6925.012388696748 1.004756238905212 1.0747513657820262 0.8762636200729758 1.0101369928584722 1.0122357847974706 1.0174917984459648 1.1336656346418679 1.0889771013871195 0.9925642962491927 1.0 12.757600936776313 -7.01575412144132 21.183588147177492 1.0632682836069212 0.9962654983118169 0.16733372968464866 0.05974839173205817 153.20070342420144 205998.9692712947 0.02252928543608872 0.018071823918900436 9.643748560002201e-08 7.01575412144132 -0.06700278529510428 RDSFIGTPY(ph)WMAPEVVMCETSK ddPTM_A459_Selumetinib_30min_R2 1 RDSFIGTPYWMAPEVVMCETSK 22 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 RDS(0.291)FIGT(0.34)PY(0.369)WMAPEVVMCETSK 60.036 0.011952 1655800.0 7912.4 8137.2 7147.2 7261.3 7554.8 6727.0 6719.8 5652.5 5216.3 6878.9 True False 7472.660483846806 8761.297074778118 6687.356933282976 6272.298413558824 6605.698483231077 7653.583188373991 7032.284015031095 5668.947839178251 6259.705755599612 6680.288283471378 1.1186134739627847 1.3115148183732805 1.001058135444407 0.9389263078777575 0.9888343441068473 1.145696542364912 1.0526916978164906 0.8486082633895571 0.9370412607922344 1.0 12.705694647265657 -5.283634461644867 20.376913095671735 0.9897614261128612 1.2150638351639096 0.5301270547542265 0.08508971276882935 53.15404923547934 48800.2025562613 0.023707421286186678 0.04950616602780803 5.204338526531511e-06 5.283634461644867 0.22530240905104837 RDSQGTYS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 RDSQGTYSSR 10 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.046)QGT(0.394)YS(0.543)S(0.017)R 97.452 0.03702 765660.0 3802.3 2562.9 3422.4 2320.2 3791.1 2951.7 5017.3 11928.0 4696.6 5532.9 True False 3590.983387812891 2759.466188977637 3202.2065100273758 2004.1847574317514 3314.8281251359836 3358.269882135201 5250.614391591343 11962.708505213304 5636.051233968356 5373.150800799372 0.668319859416314 0.5135657440634473 0.5959643845378355 0.3729999085701421 0.6169244542034502 0.6250094230810693 0.977194682645088 2.2263861463619437 1.0489285417282301 1.0 12.39155261340364 -7.527677505707032 24.998707592128287 1.5029526683435945 0.5783337002670838 0.5859274689383159 0.32262801562829685 82.7157089999107 430890.05136535945 0.14202109467043683 0.08237517453682203 2.967033803627277e-08 7.527677505707032 -0.9246189680765108 RDSQGTYSS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RDSQGTYSSR 10 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RDS(0.302)QGT(0.022)YS(0.189)S(0.488)R 107.34 0.020377000000000003 1107600.0 1208.5 1924.9 993.28 541.6 1086.0 3245.5 6533.6 10178.0 4268.3 4898.6 True False 1141.3364080088038 2072.533640470973 929.3734462014942 467.83314568788785 949.5669710368176 3692.5381652843425 6837.425346082789 10207.61629494139 5122.07926626648 4757.164689908692 0.23991946514483828 0.43566573275619613 0.19536289087761904 0.0983428525567542 0.1996077564964528 0.7762056615608186 1.4372900228968162 2.1457353193162865 1.0767084177539357 1.0 12.215886255979225 -7.068600273095644 2.6506641745664896 1.515417293008293 0.23732087770993002 0.7666841778494611 0.304861696883244 0.12399949776103569 1.7153749080594836 0.12589757640020538 0.09642174584111457 8.538856732691974e-08 7.068600273095644 -1.278096415298363 RDT(ph)DSDTQDANDSSCK ddPTM_A459_Selumetinib_30min_R1 1 RDTDSDTQDANDSSCK 16 1 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2;A0A087WWE6;A0A087X246 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 RDT(1)DSDTQDANDSSCK 291.08 1.3989999999999996e-74 3341600.0 1423.5 1816.8 1661.5 1656.6 1572.8 1738.2 1277.6 1649.2 930.22 1307.6 True False 1456.664780351172 1604.0882113925938 1435.8774259662143 1367.3059082333464 1430.5405177003938 1720.7152861593263 1181.2296033983396 1605.457858643418 1578.5153994192929 1475.4431971025942 0.9872726942058506 1.0871907604051627 0.9731838059139943 0.926708605874084 0.9695666498782344 1.1662362126433508 0.8005930731308277 1.0881190558851337 1.0698584686412238 1.0 10.526932664370772 RDT(ph)DSDTQDANDSSCK ddPTM_A459_Selumetinib_30min_R2 1 RDTDSDTQDANDSSCK 16 1 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2;A0A087WWE6;A0A087X246 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 RDT(0.999)DS(0.001)DTQDANDSSCK 203.26 4.7455e-07 3778200.0 19248.0 18820.0 16864.0 21409.0 19860.0 14734.0 15432.0 16215.0 12472.0 17899.0 True False 18178.27321584895 20263.433484162142 15778.988600134893 18493.05726741505 17365.009249347335 16763.47475806487 16149.618577927882 16262.18296546225 14966.74849679627 17382.209362812977 1.0457976219489709 1.165757071567276 0.907766571601193 1.0639071755158231 0.9990104759926296 0.9644041449603172 0.9290889461081935 0.9355647850067391 0.8610383285806994 1.0 14.085323846868386 -5.795592008840967 0.5546653892014864 0.9229742127710069 1.1182120882219635 0.3937129069494195 0.06528216726883451 1.49937787559706 0.7422261962993962 0.04338152725427823 0.1672638786795947 1.6010614144445297e-06 5.795592008840967 0.1952378754509566 RDTDSDTQDANDSSCK ddPTM_A459_Selumetinib_30min_R1 1 RDTDSDTQDANDSSCK 16 1 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1;F8WF49;A0A0B4J2C2;A0A087WWE6;A0A087X246 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 0 124.43 0.0015448 0.0 461.88 587.3 749.62 597.72 469.5 519.23 392.04 361.55 218.99 599.14 False True 472.6409053379692 518.538642971637 647.8257213679165 493.33942259400925 427.03380789695734 514.0070176231199 362.46810716678544 351.96051952008736 371.61003560322393 676.0454551178103 0.6991259267553317 0.7670174232312152 0.9582576385415147 0.72974297639208 0.6316643424849898 0.7603142861651914 0.5361593727504911 0.5206166491552752 0.549682026245507 1.0 9.400976441708776 -6.000947902506765 24.987907920397735 0.6442639731784129 0.810685090801363 0.14997883520345268 0.1456796230755647 55.593404386609855 1465619.9238633122 0.04061689266095114 0.05940147947834329 9.97819754014827e-07 6.000947902506765 0.1664211176229501 RDTVSLY(ph)QRT(ph)LEQR ddPTM_A459_Selumetinib_30min_R1 1 RDTVSLYQRTLEQR 14 2 Q96JK9 Q96JK9 MAML3 Mastermind-like protein 3 2 RDTVSLY(1)QRT(1)LEQR 106.4 0.025382 82452000.0 2846.5 3160.6 2584.1 3002.8 3071.0 2187.3 2864.9 2422.7 1612.4 2315.3 True False 2912.8179116751744 2790.5554826769244 2233.1934134452576 2478.41734953706 2793.228592229087 2165.2977479095002 2648.7982864557785 2358.4421259613205 2736.1250349634165 2612.4913079318126 1.1149579341494982 1.0681587625591287 0.8548137200169951 0.9486796537895881 1.0691819657920147 0.8288248620523317 1.0138974542857746 0.9027559704412526 1.047324072105518 1.0 11.351210521846218 -5.065816224746982 7.476698205652974 0.9557621346860102 1.1038289143940583 0.3445328002008966 0.07475530429077301 0.2431452092138974 24.612700127846647 0.018004948995877634 0.04891679918349165 8.593770970044495e-06 5.065816224746982 0.14806677970804805 RDTVSLY(ph)QRT(ph)LEQR ddPTM_A459_Selumetinib_30min_R2 3 RDTVSLYQRTLEQR 14 2 Q96JK9 Q96JK9 MAML3 Mastermind-like protein 3 2 RDTVSLY(1)QRT(1)LEQR;RDTVSLY(1)QRT(1)LEQR;RDTVSLY(1)QRT(1)LEQR 108.7 0.022029 24436400.0 52329.0 51644.0 48503.5 55121.3 48975.7 37344.1 47995.9 49252.2 43880.2 43867.9 True False 49420.76366958436 55604.928738367125 45382.837616617835 47613.683850453795 42822.93471768679 42487.9107990125 50227.804452071614 49395.515747859376 52657.466115227646 42601.3197445077 1.1600758841738898 1.3052395811173405 1.0652918240277929 1.1176574842283449 1.0052020682577012 0.9973379006524833 1.179019916596531 1.1594832283154233 1.2360524610746693 1.0 15.378610503882356 -5.272193911735709 24.738672818676243 1.0978155419152325 1.2326577361345348 0.302571419479593 0.083507571783359 710.6308833040521 1634666.97581825 0.022871304407534515 0.048410222885968315 5.343257306118628e-06 5.272193911735709 0.13484219421930232 RDVYLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 RDVYLSPR 8 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 RDVYLS(1)PR;RDVYLS(1)PR;RDVYLS(1)PR;RDVYLS(1)PR 133.91 0.005280600000000001 164955000.0 14971.699999999999 18546.8 18500.5 19712.800000000003 18385.7 16766.8 17744.3 15888.3 9164.8 13669.899999999998 True False 15320.51148014304 16375.332033826593 15988.233715972285 16270.3295350853 16722.716681258975 16598.14121503635 16405.8331649821 15466.89067152814 15551.996229491888 15424.56482110184 0.9932540501358945 1.0616398079136755 1.03654358495089 1.0548323225836749 1.0841613280642561 1.07608489494167 1.0636172465973122 1.0027440547540372 1.008261588567848 1.0 13.912942166214593 -7.7666199565512235 24.945872681835887 1.0041270973226797 1.054756218495178 0.4748391977873804 0.023655311811686563 112.52581054210248 541828.3353816537 0.012935182074032282 0.006512609287219207 1.711512374291315e-08 7.7666199565512235 0.05062912117249829 RDVYLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 RDVYLSPR 8 1 H3BT71;H0Y6E7;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 RDVY(0.001)LS(0.999)PR;RDVYLS(1)PR;RDVYLS(1)PR;RDVYLS(1)PR 97.214 0.010499 215540000.0 186767.0 198131.0 203502.0 224060.0 223571.0 161805.0 169123.0 165371.0 154928.0 204065.0 True False 176387.2378275388 213327.01060842373 190408.90287622463 193542.6414749412 195484.01222990084 184092.17003045228 176987.5546108668 165852.20223135725 185917.9290500044 198173.11322545563 0.8900664421962646 1.0764679786088236 0.9608210709169317 0.9766342079652022 0.9864305457395954 0.9289462482280133 0.8930956966372796 0.8369056706631649 0.9381591984099837 1.0 17.596401715227998 -6.888795244409805 3.496264749742715 0.9040192999950522 0.9826953138439781 0.19276529624260463 0.05741461413734622 0.30373636970251844 7.226233131869512 0.020436594101509886 0.01782927424664284 1.291828184639413e-07 6.888795244409805 0.07867601384892597 RDWGDHGR ddPTM_A459_Selumetinib_30min_R2 1 RDWGDHGR 8 1 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 105.1 0.019344 2621800.0 3766.1 4028.6 3368.2 2293.0 3538.8 2582.4 3794.6 4730.7 3807.1 5647.2 False True 3556.7952388928065 4337.580666009328 3151.493679018879 1980.689444354369 3094.2243067266027 2938.10215930682 3971.0564188572553 4744.465553790456 4568.62637926179 5484.1506628123025 0.6485589943783314 0.7909302520483623 0.5746548322220556 0.3611661251003379 0.56421212635684 0.5357442455456074 0.7240968862844618 0.8651231239802352 0.8330599686550139 1.0 12.421052490627224 -7.612542132519948 2.1912647454732577 0.901871921645221 0.5777448706532723 0.641702618239415 0.10730347735656119 0.23281019246345777 2.2309253237429023 0.07319750778427636 0.03545257484318611 2.4403823060104926e-08 7.612542132519948 -0.3241270509919487 RDYDDMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 RDYDDMSPR 9 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 RDYDDMS(1)PR;RDYDDMS(1)PR;RDYDDMS(1)PR 191.33 0.0011841 1173751100.0 18100.4 18454.989999999998 22952.3 23870.7 21003.2 16605.83 17300.760000000002 15678.58 9959.27 12569.74 True False 18522.104102752615 16294.271191307918 19835.503727959265 19702.13035353481 19103.464268416134 16438.79042708729 15995.749744278208 15262.733127194717 16900.153793698886 14183.188568635956 1.3059196113144498 1.1488440072876358 1.3985221751773487 1.3891185510360613 1.346908995531558 1.1590334816135257 1.1277964518959063 1.0761143767732184 1.1915623706132696 1.0 13.791894285542574 -6.876985357723799 4.08949690780179 1.1095033173777575 1.3167457748488685 0.6383128939679532 0.07860633729424996 0.1603754096498886 4.87744385305413 0.029999142270175038 0.02640429403577698 1.3274392117036796e-07 6.876985357723799 0.20724245747111092 RDYDDMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 RDYDDMSPR 9 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 RDYDDMS(1)PR;RDYDDMS(1)PR;RDYDDMS(1)PR 157.03 0.0015271 1033394900.0 460416.0 451299.0 508405.0 500171.0 541259.0 383655.0 355082.0 384807.0 294683.0 433176.0 True False 434827.9219112797 485912.182145 475694.77580951 432046.8469568981 473261.2055031461 436499.99377666495 371594.01658163493 385926.7246617719 353627.8341309663 420669.08335358877 1.0336579014669112 1.1550936386180106 1.1308051735517488 1.0270468262431016 1.1250201743619737 1.0376326928921698 0.8833404480768454 0.9174116661608466 0.84063186034931 1.0 18.682326267034945 -7.1199150680979875 3.5583900458819255 0.9034641777671211 1.095423594497284 0.7252178709313755 0.05336360889379972 0.12201940349706036 2.8099474706369754 0.020811334123060986 0.01585403984362002 7.587259391903141e-08 7.1199150680979875 0.19195941673016303 RDYDDMSPR ddPTM_A459_Selumetinib_30min_R1 2 RDYDDMSPR 9 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 163.38 0.0012947000000000002 12730800.0 3167.24 3815.3 3513.3999999999996 3842.8 5980.4 3008.3700000000003 4756.67 3819.48 1490.1799999999998 2263.31 False True 3241.030529623773 3368.602902315152 3036.2995777247643 3171.727118289936 5439.473875925378 2978.1085291814115 4397.870552283011 3718.1749829804526 2528.7266215590307 2553.8278850063284 1.2690872977979648 1.3190406926372817 1.1889209901540567 1.2419502257420438 2.12992970585874 1.1661351756185525 1.7220700651375782 1.4559223058100639 0.9901711217131473 1.0 11.31844558268039 -8.262173596293277 24.9999766797621 0.9950854934103127 1.4415738819794877 0.2863134050223274 0.2787618352080069 85.22085462136445 2901459.5520448796 0.22372939632496788 0.07082235004018539 5.467973532378497e-09 8.262173596293277 0.44648838856917494 RDYDDMSPR ddPTM_A459_Selumetinib_30min_R2 2 RDYDDMSPR 9 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 104.82 0.01908 15558500.0 111699.0 103940.0 108887.0 151306.0 127619.0 84873.0 100838.0 101260.0 101199.0 111627.0 False True 105491.21674652488 111911.86378022365 101881.32896720168 130697.86178259143 111586.3602916644 96563.48534961567 105527.16680670639 101554.6498355046 121441.62773631194 108404.03846822304 0.9731299519569835 1.0323588065681601 0.9398296447882485 1.205654914977208 1.0293561187240658 0.8907738744246301 0.9734615822236183 0.9368161119317873 1.1202684830963257 1.0 16.726058978080175 -6.548612120123806 24.849567115631032 0.9774648668226559 1.0412575119935745 0.08249420427252874 0.08492293596070277 485.03614306521234 468373.7102811582 0.028175885941783083 0.028176690285774745 2.827404076860165e-07 6.548612120123806 0.06379264517091865 REAALPPVS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 REAALPPVSPLK 12 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 REAALPPVS(1)PLK 93.495 0.01038 6390500.0 33317.0 28314.0 32725.0 36119.0 35108.0 27787.0 31326.0 27342.0 25928.0 32277.0 True False 31465.374518518285 30485.59275614063 30619.509128285987 31199.529891249655 30697.419170497767 31614.407024728396 32782.7210712914 27421.56069328824 31114.324488849725 31345.079144282605 1.0038377754186536 0.9725798622429465 0.9768521874627659 0.9953565517457148 0.979337746419346 1.008592349670137 1.0458649959182198 0.8748282487042301 0.9926382493924897 1.0 14.935951352038664 -7.739741259352465 24.999762229920666 0.9502997977575752 0.9953839452543164 0.20252207042216586 0.03724758762135539 322.71173879728184 371817.2337160242 0.016808804508482066 0.009693886710710652 1.8207853090920423e-08 7.739741259352465 0.04508414749674117 REASSS(ph)SPEAGEGQIR ddPTM_A459_Selumetinib_30min_R1 1 REASSSSPEAGEGQIR 16 1 J3QSS7;Q86U28-2;Q86U28 J3QSS7 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial 1 REAS(0.022)S(0.092)S(0.881)S(0.005)PEAGEGQIR 209.23 1.0084e-07 2954600.0 851.6 1185.7 1341.6 1457.9 1253.4 856.64 1144.6 1122.9 747.23 949.04 True False 871.4406230748557 1046.8776927830243 1159.418088881295 1203.305133172399 1140.0301913057433 848.0229793668882 1058.2619004772528 1093.117044306751 1267.9947344801 1070.8585284324308 0.8137775438465324 0.9776059722057677 1.0826995892524678 1.1236826352159228 1.0645945855934573 0.7919094416778479 0.988236888794622 1.0207856736285261 1.1840917365025292 1.0 10.064552182294369 -4.800330816490621 3.4452070168901643 1.027257014440603 0.7917061220119445 0.3077560443635329 0.09810219157654661 0.38449239968904214 7.5118770031213735 0.0266437487322399 0.2325357083765659 1.5836863865154207e-05 4.800330816490621 -0.23555089242865856 REASSSS(ph)PEAGEGQIR ddPTM_A459_Selumetinib_30min_R1 1 REASSSSPEAGEGQIR 16 1 J3QSS7;Q86U28-2;Q86U28 J3QSS7 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial 1 REASS(0.029)S(0.086)S(0.885)PEAGEGQIR 268.82 3.9095e-50 2869700.0 767.85 752.91 815.64 823.33 1001.5 646.83 576.01 517.72 271.26 573.3 True False 785.7394110239875 664.7589471816374 704.8805679898181 679.550871318219 910.9145018291858 640.3234774746503 532.5611019516884 503.98838380843495 460.30840795347086 646.8886394148956 1.2146440100334441 1.0276250140718275 1.089647467958899 1.0504912745613622 1.4081473167516112 0.989851171375983 0.8232655042966665 0.7790960500779354 0.7115728734544099 1.0 9.33737356630212 -7.074494252008343 4.1194521722380975 0.8138098953287298 1.1457560368116309 0.6139420637433713 0.12214299503503133 0.15472281162341092 4.964585521114243 0.04805095728301413 0.037457792121040605 8.42375540406989e-08 7.074494252008343 0.331946141482901 REASSSS(ph)PEAGEGQIR ddPTM_A459_Selumetinib_30min_R2 1 REASSSSPEAGEGQIR 16 1 J3QSS7;Q86U28-2;Q86U28 J3QSS7 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial 1 REAS(0.072)S(0.072)S(0.054)S(0.803)PEAGEGQIR 63.302 0.031888 4353200.0 19582.0 15937.0 21420.0 24126.0 23849.0 15967.0 17730.0 21202.0 13458.0 19338.0 True False 18493.710832956906 17159.316654468224 20041.86052033264 20839.997180328617 20852.875407234857 18166.309316005274 18554.480131328502 21263.694309819944 16149.976047938102 18779.66169384196 0.9847733752850925 0.9137180921685578 1.067210945919466 1.109711001192437 1.1103967551275284 0.9673395406245358 0.9880092854608079 1.132272490126514 0.8599716177652892 1.0 14.196883453349834 -10.453873672702015 14.830124105973347 0.9999999632967072 1.0202608064890188 0.0 0.08545227451189241 0.0 0.0 0.08280737731326077 0.020083739014291165 3.5166271707618924e-11 10.453873672702015 0.020260843192311695 REDEGEPGDEGQLEDEGS(ph)QEKQGR ddPTM_A459_Selumetinib_30min_R1 1 REDEGEPGDEGQLEDEGSQEKQGR 24 2 Q969E4 Q969E4 TCEAL3 Transcription elongation factor A protein-like 3 1 REDEGEPGDEGQLEDEGS(1)QEKQGR 79.304 0.00032639 5445400.0 438.02 508.15 536.87 574.03 535.0 443.39 498.82 488.2 269.27 422.26 True False 448.22501376144714 448.6555617674743 463.966002815818 473.7864363776338 486.6093444619219 438.92989916590926 461.1936057977142 475.25135010290853 456.93152329732004 476.461184160708 0.9407377319749578 0.941641369081904 0.9737750277246605 0.9943862210144446 1.0212990284173726 0.9212290817332569 0.9679563018551285 0.9974607919847015 0.9590110138818765 1.0 8.896214876732936 -5.289485364642019 4.392733181892245 0.9791320173340415 0.9405552113527609 0.2611372401007639 0.025827277722440173 0.2748351175272453 13.022421528292481 0.007020965935574732 0.016817684828499834 5.13469480700119e-06 5.289485364642019 -0.03857680598128066 REDFQDISVPVQEDELS(ph)KVEESSEISPEPK ddPTM_A459_Selumetinib_30min_R1 1 REDFQDISVPVQEDELSKVEESSEISPEPK 30 2 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 REDFQDISVPVQEDELS(0.53)KVEES(0.157)S(0.157)EIS(0.157)PEPK 63.479 0.00034055 12195000.0 967.16 1314.3 1071.2 1529.1 1047.1 786.53 966.64 1153.1 760.75 755.86 True False 989.6929462342385 1160.4211449985062 925.736923680414 1262.071389761928 952.38998988052 778.6182223121011 893.7255665536711 1122.5160422033255 1290.9371870183688 852.8819936998831 1.1604101781312752 1.3605881629233243 1.08542205195877 1.479772581769422 1.1166726427755402 0.9129260883259844 1.047888891025363 1.3161446137861865 1.5136175890150532 1.0 9.736202331223005 -4.4354792440553386 16.164572955355304 1.2052622611146677 0.0004659928499830598 0.004337051613077514 0.1953021157854251 5807309.917613391 14665743.935043676 0.05027232353038415 247301161.29622632 3.668772279394507e-05 4.4354792440553386 -1.2047962682646847 REDGGAGS(ph)TEK ddPTM_A459_Selumetinib_30min_R1 1 REDGGAGSTEK 11 1 Q9H091-2;Q9H091;Q9H091-3 Q9H091-2 ZMYND15 Zinc finger MYND domain-containing protein 15 1 REDGGAGS(0.996)T(0.004)EK 72.2 0.031443 1205200.0 649.62 978.7 701.86 834.09 853.23 708.03 1086.6 833.33 391.57 717.52 True False 664.7548820595209 864.1133490147137 606.5512670410153 688.4318393084346 776.0554971499913 700.9078610398036 1004.6368871733216 811.2273813626729 664.4656908587356 809.6206812366578 0.8210695421516887 1.06730641773481 0.7491795616121572 0.8503140486195179 0.9585420866035719 0.8657237608718191 1.2408735478925583 1.0019845097380182 0.8207123487060574 1.0 9.661102332989362 REDIFYT(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 REDIFYTSK 9 1 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 1 REDIFYT(0.992)S(0.008)K 99.844 0.023021 5614500.0 2415.2 2704.7 2092.4 3402.2 2995.9 2404.6 2741.7 3203.5 1509.2 2428.0 True False 2471.4694608388836 2388.0324666190827 1808.2635727304885 2808.069637203606 2724.9213739691045 2380.411907202115 2534.8913616446666 3118.5327735654814 2561.0021723931955 2739.657450722773 0.9021089334313908 0.8716536682310685 0.6600327249866347 1.0249710731036046 0.9946211973508656 0.8688720944197303 0.9252585066705747 1.1382929543774731 0.9347891911514541 1.0 11.41977980374655 -5.791267286071196 24.999430411581436 0.9828108626977741 0.8173037202997747 0.4386805675010239 0.08936868229004738 194.43112709402666 162956.299193278 0.025902111552861217 0.038424866364842256 1.6170844984096076e-06 5.791267286071196 -0.16550714239799935 REDIFYT(ph)SK ddPTM_A459_Selumetinib_30min_R2 4 REDIFYTSK 9 1 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 1 REDIFYT(0.99)S(0.01)K;REDIFYT(0.825)S(0.175)K;REDIFYT(0.895)S(0.105)K;REDIFYT(0.948)S(0.052)K 107.09 0.015961000000000003 39184300.0 196265.0 135641.0 143540.0 141697.0 140924.0 95108.0 143860.0 162782.0 132122.0 128263.0 True False 185357.37701104503 146044.22854544266 134304.792674535 122397.62415904131 123219.86724345533 108208.26369553647 150549.77505318198 163255.66866998933 158550.091797123 124559.71392270402 1.4881005356681312 1.172483654193931 1.0782362004931896 0.9826421425068108 0.9892433384996361 0.8687260133134659 1.2086554337031168 1.3106618787780633 1.2728841999068161 1.0 16.92647801052091 -4.75983924074041 2.8025276582801846 1.0897867376247632 1.574159073784457 0.44921733082481174 0.13237282614412788 0.49877756830441755 5.133180033278689 0.03867507660777629 0.5777459775580706 1.738444215433251e-05 4.75983924074041 0.4843723361596939 REDIFYTS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 REDIFYTSK 9 1 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 1 REDIFYT(0.01)S(0.99)K;REDIFYT(0.012)S(0.988)K 140.45 0.0011766 25695000.0 4199.8 8682.7 5771.9 6511.299999999999 6412.3 5879.6 8368.7 8108.4 2864.8 7221.1 True False 4297.647168611766 7666.125447522279 4988.107682777243 5374.223687238797 5832.308597183515 5820.456562249665 7737.442221320979 7893.338892204886 4861.356363286528 8147.99852447044 0.5274482016295016 0.9408599454821969 0.612188093529562 0.6595759278918232 0.7157964719394169 0.7143418773051327 0.9496126193547458 0.9687457439393553 0.5966319641181428 1.0 12.99223000370676 -7.193662276252515 7.542632823981631 0.875889782144443 0.7011753938481244 0.28258116065769445 0.1432050022754508 0.4022664510382704 40.028602754262494 0.052866964247902416 0.04083333607256824 6.402325108677806e-08 7.193662276252515 -0.17471438829631858 REDIFYTS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 REDIFYTSK 9 1 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 1 REDIFYT(0.038)S(0.962)K 145.83 0.00092898 20107000.0 59117.0 39294.0 50057.0 46375.0 41044.0 30261.0 36602.0 40697.0 35786.0 33073.0 True False 55831.51380410138 42307.72344987604 46836.387117940765 40058.644998662814 35887.68578198446 34429.178067992456 38304.06552548707 40815.42153224895 42944.19994438352 32118.096556026234 1.7383195080290603 1.3172550053230956 1.4582553806151062 1.2472297332061764 1.1173665201293177 1.0719557433279028 1.1926007339404483 1.2707920427678912 1.3370717616927401 1.0 14.971098775189486 -1.5228787452803771 0.6270421259374401 1.1776463708822908 41.74751197081623 0.6813757981785622 0.11333931814319535 120.92168978288012 0.8502350984607474 0.05085799110599835 6772.069844497171 0.029999999999997265 1.5228787452803771 40.569865599933934 REDIFYTSK ddPTM_A459_Selumetinib_30min_R1 1 REDIFYTSK 9 1 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 157.97 0.001172 156570000.0 13389.0 13164.0 13911.0 14825.0 13777.0 11575.0 13158.0 13012.0 8171.3 10670.0 False True 13700.93764954115 11622.752760222435 12021.96260765332 12236.092049715908 12530.8727825269 11458.566009259113 12165.48146643342 12666.879491067277 13866.099291860928 12039.598434601316 1.137989586942137 0.9653771114839774 0.9985351814644158 1.0163206120355208 1.040804878218669 0.9517398833110298 1.01045575004149 1.052101493241102 1.1517077888586653 1.0 13.555499653202656 -7.94376366428517 4.800529707778023 1.0838381342314787 1.0134031696754031 0.13703594189424761 0.058588497097362725 0.30150301195775087 14.29207952390057 0.03295803576159766 0.014789600945326699 1.138246531835871e-08 7.94376366428517 -0.07043496455607556 REDIFYTSK ddPTM_A459_Selumetinib_30min_R2 3 REDIFYTSK 9 1 P52895;B4DK69;H0Y804;S4R3P0;P52895-2;P17516;Q04828;A6NHU4;A0A0A0MSS8;P42330;S4R3Z2;S4R3D5 P52895;Q04828;A0A0A0MSS8 AKR1C2;AKR1C1;AKR1C4;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C4;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 ;; 173.24 0.00059505 130780000.0 557490.0 425090.0 486700.0 528060.0 582280.0 370472.0 403762.0 461470.0 391995.0 438260.0 False True 526506.9376092906 457693.03612021677 455386.25187889306 456137.3170456904 509128.7807507529 421501.15519002295 422537.7330392252 462812.8012995288 470404.9532554235 425606.2950637697 1.237075070824323 1.0753906636922264 1.0699706681045715 1.0717353627895616 1.1962435392889779 0.9903546072476873 0.9927901394783536 1.0874200092134079 1.1052584482683498 1.0 18.699159964068485 -6.773794131684737 24.9998764963118 1.0379799928222608 1.12046348897787 0.3607626096213692 0.06246591211056877 307.4043766296995 622029.6433573524 0.022685292974337797 0.020147944319610783 1.683471886982554e-07 6.773794131684737 0.08248349615560913 REDLFIVS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 REDLFIVSK 9 1 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 REDLFIVS(1)K;REDLFIVS(1)K 114.87 0.004285499999999999 44365000.0 5292.700000000001 8409.3 7959.9 7384.4 8484.5 7251.5 8362.099999999999 10327.2 4683.200000000001 7946.900000000001 True False 5416.009612198557 7424.7352466224875 6878.989300600946 6094.85316235562 7717.078473060141 7178.5564938352 7731.340064634666 10053.289108526751 7947.048352605225 8966.962024361132 0.6039960465411284 0.8280101138435988 0.76714825845279 0.6797010119812411 0.860612373744268 0.8005561386713523 0.8622028334267983 1.1211477288756575 0.8862587274279694 1.0 13.130403572509445 -7.226582656151916 1.1789556380346136 1.004897086261833 0.7388764695474231 0.6065172291943579 0.08784033150668849 0.32426532273373954 0.8834514098373557 0.05577103111479673 0.032786831580406336 5.9349538172502896e-08 7.226582656151916 -0.2660206167144098 REDLFIVS(ph)K ddPTM_A459_Selumetinib_30min_R2 3 REDLFIVSK 9 1 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 REDLFIVS(1)K;REDLFIVS(1)K;REDLFIVS(1)K 97.957 0.010333 16350000.0 105819.0 79615.0 97626.0 90210.0 84980.0 76335.0 84914.0 88415.0 66054.0 76618.0 True False 99938.00360702 85721.21449742666 91344.8494471517 77923.24237907007 74304.05266916082 86849.453349863 88862.66925389883 88672.2730121089 79266.64570296505 74405.83926252897 1.3431473201236923 1.152076441137546 1.227657000478903 1.0472732133849134 0.99863200799323 1.1672397517542776 1.1942969817242606 1.1917380932865111 1.0653282926261407 1.0 16.183128225943534 -3.4975251069315196 1.0106722892427384 1.1127062353999175 3.8137198886772485 0.4549985940032031 0.07714843588556511 21.375999168650157 2.2173203560759056 0.02556616193445076 111.04024350738766 0.00031803498243001974 3.4975251069315196 2.701013653277331 REDLFIVSK ddPTM_A459_Selumetinib_30min_R1 2 REDLFIVSK 9 1 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 0 ; 138.76 0.0032991999999999995 157198000.0 18646.5 22674.9 21546.7 22925.3 21558.2 18645.3 21115.4 18817.8 10039.5 14612.5 False True 19080.927170226998 20020.112166724994 18620.77648755115 18921.826716178875 19608.264616409335 18457.74521057788 19522.648377893936 18318.690815171052 17036.29824393154 16488.15671280335 1.1572504739362597 1.2142116620700856 1.1293425221445028 1.147601096093764 1.189233275614318 1.1194547414899998 1.184040685562762 1.1110211489527062 1.0332445609703933 1.0 14.00914250179725 -8.203644190367262 2.095933925930246 1.0018331321064167 1.1627597484524639 0.821485005471183 0.027147760619387982 0.12257123385422973 0.9656814257245158 0.02418132973724601 0.00720051843909747 6.25685095354872e-09 8.203644190367262 0.1609266163460472 REDLFIVSK ddPTM_A459_Selumetinib_30min_R2 3 REDLFIVSK 9 1 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 0 ;; 150.04 0.0018425 29432000.0 118948.0 116364.0 130519.0 116551.0 134780.0 99439.0 90491.0 103426.0 87733.0 112704.0 False True 112337.3463465711 125288.74463076759 122121.54963834249 100676.55273831038 117847.73145151214 113135.81963263286 94699.01080451484 103726.95253690389 105282.05146483549 109449.9426798411 1.0263810432059899 1.1447127477924548 1.115775364045351 0.9198410732183359 1.0767272103214887 1.0336763717051323 0.8652266824983624 0.9477113463670064 0.9619196583117693 1.0 16.739911673400343 -6.282963171139662 0.807068139817193 0.9467982133343276 1.0973574411399822 0.35421567616930383 0.0672300178607342 0.7219584592348078 1.0166866962588992 0.03818720858776669 0.0634070704848483 5.212389111166637e-07 6.282963171139662 0.15055922780565467 REDPSFER ddPTM_A459_Selumetinib_30min_R1 1 REDPSFER 8 1 Q9NWH9;Q9NWH9-3;H7C3F4;H0YMM0 Q9NWH9 SLTM SAFB-like transcription modulator 0 101.46 0.023021 2152000.0 673.44 1001.1 730.76 790.6 756.07 793.62 842.32 708.97 379.43 620.04 False True 689.1298417138696 883.8907466012364 631.526805777352 652.5365514000263 687.6836019950001 785.636903349306 778.7831242442777 690.1658125408829 643.8649975292539 699.6281737010498 0.9849944122009212 1.263372145128795 0.9026606267677302 0.9326905003669196 0.9829272574275237 1.1229349144035579 1.1131385977847295 0.9864751570679169 0.9202959825405438 1.0 9.45044457686216 -5.273504103532241 24.91306611213981 1.000769131182426 1.124183296691245 0.23159647682276696 0.09357223135401198 983.929900280809 2031767.6498074983 0.02536224574826242 0.05344101946994938 5.327161908065736e-06 5.273504103532241 0.12341416550881901 REDPSFER ddPTM_A459_Selumetinib_30min_R2 1 REDPSFER 8 1 Q9NWH9;Q9NWH9-3;H7C3F4;H0YMM0 Q9NWH9 SLTM SAFB-like transcription modulator 0 85.86200000000002 0.046922000000000005 4010500.0 9129.2 6397.2 10068.0 9639.7 10413.0 6221.4 7416.9 7978.1 6493.5 9938.7 False True 8621.835611083141 6887.844669759937 9420.235841209573 8326.756230589972 9104.825846598871 7078.341377753817 7761.800546308536 8001.314950154446 7792.381443549272 9651.743907156231 0.8932930353332862 0.7136373215054932 0.9760138615183306 0.8627203861486777 0.9433347936063813 0.7333743462158814 0.8041863336794082 0.829001994574464 0.8073547659891447 1.0 13.2365739212293 -6.748053961793051 24.998465768510204 0.8221837658389841 0.8732982899977312 0.043746016197359516 0.09030777917773322 686.7004430379845 1282473.2432811407 0.028927363945936098 0.028769719559761636 1.786265614666024e-07 6.748053961793051 0.051114524158747066 REDS(ph)APPSSVAR ddPTM_A459_Selumetinib_30min_R1 1 REDSAPPSSVAR 12 1 Q9BZE4-2;Q9BZE4;Q9BZE4-3 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 1 REDS(1)APPSSVAR 95.822 0.0090788 4047700.0 969.83 1239.2 1509.0 1148.5 935.95 863.58 889.05 993.1 587.93 820.7 True False 992.4251520393229 1094.1138879115501 1304.0860883436749 947.9360350150909 851.2934877553931 854.8931692679035 821.9882427217382 966.7597619565722 997.674269291764 926.044839294967 1.071681531960044 1.1814912642292144 1.4082321211751745 1.0236394554466612 0.9192789070597436 0.9231660638795482 0.8876333065551653 1.043966470017373 1.0773498506307007 1.0 9.85493824056296 -5.959499462456063 13.832589001136338 0.9705379709634927 1.216539399148503 0.5781270690382248 0.09400620484148899 1.200373062649146 408.6419396387839 0.027616561378065296 0.04095826577262996 1.0977426489935796e-06 5.959499462456063 0.24600142818501025 REDS(ph)APPSSVAR ddPTM_A459_Selumetinib_30min_R2 1 REDSAPPSSVAR 12 1 Q9BZE4-2;Q9BZE4;Q9BZE4-3 Q9BZE4-2 GTPBP4 Nucleolar GTP-binding protein 1 1 REDS(0.999)APPSSVAR 67.095 0.037642 6089200.0 6850.3 7046.8 8836.8 13804.0 11559.0 4994.0 9393.8 7870.0 7910.7 9260.0 True False 6469.587749923633 7587.266900966722 8268.249908780364 11923.87138677179 10106.855081228892 5681.87816898167 9830.630313461572 7892.900397051362 9493.061043425767 8992.639739630606 0.7194314391815486 0.843719655256465 0.9194463637125535 1.3259589766754731 1.1239030333538143 0.6318365166950485 1.0931862721174004 0.877706727454822 1.0556478762948551 1.0 13.134528957716732 -5.176255346002827 2.6827591206046506 1.0068854082831091 0.7450888653374023 0.232074255359637 0.17009772718807967 0.46191222067661075 6.226726572010608 0.047718294815236824 0.1770408119530266 6.664148314720714e-06 5.176255346002827 -0.26179654294570687 REDS(ph)FESLDSLGSR ddPTM_A459_Selumetinib_30min_R1 1 REDSFESLDSLGSR 14 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 REDS(0.998)FES(0.002)LDSLGSR 73.735 0.024704 2117600.0 426.35 502.98 418.94 380.98 487.27 472.44 552.36 374.93 217.75 395.09 True False 436.28312546731405 444.0908677709421 362.05024907269694 314.44899488032155 443.1965145345056 467.68768254119897 510.695040492413 364.98563845572204 369.5058461692407 445.80365000249645 0.9786441305827597 0.9961579896630619 0.8121293961381193 0.70535311875208 0.9941518301432115 1.0490889487750492 1.1455604737411933 0.8187138854822704 0.8288533442181811 1.0 8.800264618438213 REDS(ph)FESLDSLGSR ddPTM_A459_Selumetinib_30min_R2 1 REDSFESLDSLGSR 14 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 REDS(0.999)FES(0.001)LDSLGSR 104.16 0.0032761 1733000.0 6490.8 6574.9 7186.8 6879.9 6434.1 4698.8 4658.2 5989.3 4502.0 6481.7 True False 6130.067320731107 7079.173688364378 6724.4091123962 5942.845751510518 5625.790836416194 5346.017048540463 4874.815530048187 6006.727871418007 5402.525796390057 6294.556479520913 0.9738680303648137 1.1246501181451283 1.0682895823198657 0.9441246211461171 0.8937549221648068 0.8493079799877109 0.7744494065480552 0.9542734092482379 0.858285379433318 1.0 12.619889012512983 -5.931451285889509 2.771694218953663 0.8790977087348055 1.0635750974763873 0.5505744830375483 0.06697262627071286 0.1827891654144483 2.8473420392669593 0.01983242570514287 0.031184704123262998 1.170977941658201e-06 5.931451285889509 0.18447738874158182 REDS(ph)PGPEVQPMDK ddPTM_A459_Selumetinib_30min_R1 2 REDSPGPEVQPMDK 14 1 O75382-3;O75382-2;O75382;E9PMW5;E9PMK8 O75382-3 TRIM3 Tripartite motif-containing protein 3 1 REDS(1)PGPEVQPMDK;REDS(1)PGPEVQPMDK 193.31 0.00014340000000000002 45630000.0 7576.2 7785.4 9006.2 9221.4 8839.400000000001 7505.5 7894.700000000001 8168.0 3993.1000000000004 6283.3 True False 7752.710719281028 6873.881748665736 7783.207507515451 7611.055597116369 8039.877830722821 7430.001484448746 7299.1964229405685 7951.358106596799 6775.999055515018 7089.822759524875 1.0934985234808008 0.9695421143541237 1.0978000115812545 1.0735184581153654 1.134002654709751 1.0479812735045957 1.0295315793521649 1.1215171910912 0.9557360297070546 1.0 12.791533846238206 -8.273786148759426 24.989529845023803 0.9778680026345163 1.0684850509589743 0.39303985700452293 0.04617626668678714 898.6517161963128 1818828.3387188108 0.04284725325114349 0.011349080687386987 5.323703395761391e-09 8.273786148759426 0.09061704832445794 REDS(ph)PGPEVQPMDK ddPTM_A459_Selumetinib_30min_R2 4 REDSPGPEVQPMDK 14 1 O75382-3;O75382-2;O75382;E9PMW5;E9PMK8 O75382-3 TRIM3 Tripartite motif-containing protein 3 1 REDS(1)PGPEVQPMDK;REDS(1)PGPEVQPMDK;REDS(1)PGPEVQPMDK;REDS(1)PGPEVQPMDK 182.47 3.5807e-05 144232200.0 657848.0 626964.0 755253.0 780203.0 780169.0 519294.0 511675.0 555884.0 446118.0 653314.0 True False 621287.4417341953 675050.1227929984 706660.844237293 673938.0054747537 682157.1954206475 590822.0348184161 535468.9013647771 557501.5304084498 535354.0655783953 634451.1273063751 0.9792518524979734 1.0639907374095 1.1138144670614605 1.0622378564224861 1.0751926603343165 0.9312333281316867 0.8439876269716207 0.8787146974982575 0.8438066267630319 1.0 19.275149509884848 -6.869068430060899 3.919099996463753 0.8820775916096177 1.0626294083127694 0.7039918210297088 0.051862076293054324 0.11523116530974134 3.2979104366047975 0.018502120467430147 0.01631571409382271 1.351859539260327e-07 6.869068430060899 0.18055181670315168 REDS(ph)YHVR ddPTM_A459_Selumetinib_30min_R1 1 REDSYHVR 8 1 B1AVT0;P49760-2;P49760-3;P49760 B1AVT0 CLK2 Dual specificity protein kinase CLK2 1 REDS(1)YHVR 70.41199999999998 0.036667 1954500.0 479.98 557.89 501.45 544.4 626.37 557.52 409.4 494.75 255.24 331.37 True False 491.16260012150025 492.57197944397564 433.35584426768463 449.3307596536484 569.7149440946051 551.9118549876578 378.5186283901692 481.62762282550983 433.1236380079774 373.9045673171356 1.3136041735080213 1.3173735292358426 1.1590012055138232 1.2017257849448475 1.5236907860806859 1.4760767940005965 1.012340210514519 1.288103074753314 1.1583801746947204 1.0 8.546526283879437 -8.45154086726519 0.817310543947843 1.0066564237361348 1.3070167654560765 0.3225354344463066 0.13619324356245774 0.8497647389726555 1.2755380026455325 0.13951781371182662 0.05146497178985239 3.5355674971910663e-09 8.45154086726519 0.30036034171994164 REDS(ph)YHVR ddPTM_A459_Selumetinib_30min_R2 3 REDSYHVR 8 1 B1AVT0;P49760-2;P49760-3;P49760 B1AVT0 CLK2 Dual specificity protein kinase CLK2 1 REDS(1)YHVR;REDS(1)YHVR;REDS(1)YHVR 75.566 0.029731 29967400.0 38243.0 34803.9 48694.7 45662.0 55727.0 36813.0 43194.0 41538.0 38567.4 42253.0 True False 36117.60715885866 37473.247217823075 45561.73601678063 39442.75682865646 48726.076054298996 41883.65659485827 45202.606587287286 41658.86870301393 46281.95766319277 41033.04610352182 0.8802077980693401 0.9132455612308732 1.1103668955464197 0.9612436943907786 1.1874837644606866 1.0207298890067888 1.1016146954638983 1.0152516729543606 1.1279191300209235 1.0 15.324498636761218 -5.184221285102046 5.433350093999182 1.0663094277539251 0.8905461539025145 0.5205422857644155 0.06493504119529298 0.15637273442891236 8.08489608535592 0.015257185871053467 0.04220101818462488 6.543027037159982e-06 5.184221285102046 -0.17576327385141066 REEDEPEER ddPTM_A459_Selumetinib_30min_R2 2 REEDEPEER 9 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 ; 107.55 0.016941 4845500.0 9805.0 7612.900000000001 9484.7 11603.1 9050.2 5479.28 11007.5 10185.7 8075.599999999999 13755.2 False True 9260.07735252489 8196.78495066833 8874.464728160548 10022.737763536064 7913.232966185459 6234.001084048436 11519.370560947458 10215.33870066659 9690.945651116732 13358.051635698366 0.6932206586009927 0.613621295546055 0.6643532283139424 0.750314345001562 0.5923942489515426 0.46668490690577563 0.8623540973717174 0.7647326855188135 0.7254759837294253 1.0 13.705421975647333 -8.800481453870617 0.5907091280302009 1.0034927120874353 0.6437255498513667 0.5300932251500634 0.09615300317973856 1.0327936495070729 0.7432457108355695 0.11607196563908176 0.0445628075972455 1.5831371716176919e-09 8.800481453870617 -0.35976716223606864 REEDEPEERS(ph)GDETPGSEVPGDK ddPTM_A459_Selumetinib_30min_R1 1 REEDEPEERSGDETPGSEVPGDK 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 REEDEPEERS(0.91)GDET(0.037)PGS(0.053)EVPGDK 74.308 0.0011193 8974500.0 1006.4 1691.6 1189.6 1341.3 1177.8 1276.8 1327.4 1165.2 747.29 1026.7 True False 1029.84716188649 1493.546685596496 1028.05885400506 1107.0671343193214 1071.2681979574795 1263.9565512416445 1227.273149304129 1134.2951108969867 1268.0965500978734 1158.4869459048891 0.8889587970989875 1.289221851723062 0.8874151388922624 0.9556146819199556 0.924713223350753 1.0910408232993714 1.0593758985739035 0.9791177318886348 1.0946144491143737 1.0 10.178026072339671 -6.784772650746295 24.996063344925073 1.0444337393564938 0.9983345246281393 0.05439377032087278 0.11281880509622734 989.403091183737 1059904.4150443617 0.03969836708501695 0.03503203645632965 1.6414488320197394e-07 6.784772650746295 -0.04609921472835443 REEDEPEERS(ph)GDETPGSEVPGDK ddPTM_A459_Selumetinib_30min_R2 2 REEDEPEERSGDETPGSEVPGDK 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 REEDEPEERS(0.867)GDET(0.094)PGS(0.039)EVPGDK;REEDEPEERS(0.995)GDET(0.002)PGS(0.002)EVPGDK 95.591 8.7032e-05 183876000.0 174650.0 181899.0 232668.0 180528.0 192978.0 128902.0 124429.0 118120.0 98018.0 176476.0 True False 164943.65217934435 195850.06840252955 217698.39418976434 155939.77497182984 168734.37839479098 146657.08044414813 130215.19505138596 118463.70964418146 117624.33885174584 171380.67934028583 0.9624401817887511 1.1427779908239153 1.2702621732378137 0.9099028873739191 0.9845589307051323 0.855738704086663 0.7598009037695345 0.6912314159343785 0.6863337180394541 1.0 17.386844950333668 -6.54257824036237 1.2347454160275009 0.7594893565199861 1.1109658306643881 0.5466112632821689 0.12066071917470089 0.31347678164331116 1.0003581637408876 0.05416119967478969 0.05997465029807398 2.866960831461153e-07 6.54257824036237 0.3514764741444021 REEDEPEERSGDETPGS(ph)EVPGDK ddPTM_A459_Selumetinib_30min_R1 2 REEDEPEERSGDETPGSEVPGDK 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 REEDEPEERS(0.157)GDET(0.331)PGS(0.512)EVPGDK;REEDEPEERS(0.02)GDET(0.39)PGS(0.59)EVPGDK 102.43 3.974e-05 276570000.0 6769.2 7490.9 6179.0 6130.9 6359.200000000001 5929.9 6888.0 6082.4 3704.0 4924.2 True False 6926.9091894296835 6613.861945575066 5339.925738817473 5060.253406246424 5784.011482807947 5870.25058991841 6368.4326144393835 5921.07499358036 6285.417470543592 5556.269035769802 1.2466835469693889 1.190342278783975 0.9610632070622268 0.9107286514871472 1.0409883764756527 1.0565094224428797 1.1461706719816995 1.0656566403574113 1.131229864875103 1.0 12.439900741284116 -5.105130781786973 5.257708738613386 1.0417790719618607 1.2339352469985854 0.5366919057837938 0.06744577994650257 0.1754389059353357 6.989791496758206 0.019337717963240793 0.055152363228403105 7.849992073405546e-06 5.105130781786973 0.19215617503672466 REEEEQQEGGFAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 REEEEQQEGGFASPR 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 REEEEQQEGGFAS(1)PR 94.958 0.0057135 10130000.0 17225.0 18207.0 22993.0 23526.0 24199.0 25786.0 20629.0 21920.0 18229.0 21408.0 True False 16267.703457138323 19603.418355267804 21513.655412885546 20321.71821538634 21158.90527819517 29337.787437997853 21588.28937558802 21983.78357094865 21875.30936081617 20789.89541533606 0.7824812550590391 0.942930109249466 1.0348130658231012 0.9774805408783172 1.0177494814421673 1.4111560857759908 1.0384029810781545 1.057426366595952 1.0522087256234791 1.0 14.343594880210594 -4.424989998390365 0.7706831158477152 1.1009984601482723 0.42343673820802175 0.4024704420742352 0.1144596061165929 4.486744103732413 1.3931152010375523 0.045901097182886576 2.9713741114778163 3.7584605975712884e-05 4.424989998390365 -0.6775617219402505 REEGDPS(ph)PHSGGVCKPK ddPTM_A459_Selumetinib_30min_R2 1 REEGDPSPHSGGVCKPK 17 2 O75376-2;O75376;E7EVK1;J3KRE4 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 REEGDPS(0.989)PHS(0.011)GGVCKPK 49.306 0.042457 5821900.0 12391.0 10498.0 9614.3 14037.0 11668.0 9366.9 9552.8 12054.0 6971.5 13021.0 True False 11702.357825103101 11303.162843609667 8995.726405258363 12125.136384824367 10202.161526756521 10657.105450747778 9997.02412851409 12089.07514435287 8365.994799985177 12645.049897379058 0.9254497151117332 0.8938804461303451 0.71140299787373 0.9588840283926081 0.8068106974311842 0.8427887226413142 0.7905879541516222 0.9560322214986732 0.6616023556948715 1.0 13.626285109437852 -5.015008846193692 24.765341253037654 0.8381571341630073 0.91755746338677 0.06992638684222574 0.10258167405801838 1359.3519620572115 2243024.2622993635 0.02370026895239012 0.06796203205528237 9.660312015900015e-06 5.015008846193692 0.07940032922376272 REEGPPPPSPDGASS(ph)DAEPEPPSGR ddPTM_A459_Selumetinib_30min_R1 2 REEGPPPPSPDGASSDAEPEPPSGR 25 1 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 REEGPPPPSPDGAS(0.067)S(0.933)DAEPEPPSGR;REEGPPPPSPDGAS(0.252)S(0.747)DAEPEPPSGR 185.93 1.0868e-26 33519000.0 3280.3 4706.299999999999 3038.6 3289.7 4141.2 3284.2 4744.0 4404.3 2326.5 4528.200000000001 True False 3356.7246076473116 4155.284208100486 2625.9748098350524 2715.2156503170586 3766.629191188244 3251.163929815014 4386.156260583688 4287.483656817372 3947.900579162976 5109.438578403156 0.6569654485789675 0.8132565142605412 0.5139458610843589 0.5314117409677602 0.7371904238381944 0.6363055118339626 0.8584419194553634 0.8391300905230439 0.7726681745133742 1.0 12.318949062194667 -7.262771683877995 24.46783138222566 0.8541542335113422 0.6483195880173561 0.5466405590163388 0.09757055106993272 77.35502050353942 1420600.4740604863 0.04030327247429292 0.028855820994852326 5.460448508710583e-08 7.262771683877995 -0.2058346454939861 REEGPPPPSPDGASS(ph)DAEPEPPSGR ddPTM_A459_Selumetinib_30min_R2 1 REEGPPPPSPDGASSDAEPEPPSGR 25 1 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 REEGPPPPSPDGAS(0.258)S(0.741)DAEPEPPS(0.001)GR 162.32 1.3734e-13 59082000.0 83677.0 73290.0 66408.0 65459.0 72839.0 57969.0 80688.0 73952.0 56302.0 63693.0 True False 79026.56732557106 78911.10733550692 62135.38157956349 56543.37127692662 63688.31363107811 65953.70355981134 84440.1518802387 74167.18807658738 67563.97320931884 61854.017595711855 1.2776303043417785 1.2757636513004385 1.0045488392636137 0.9141422574440273 1.029655244827515 1.0662800271260586 1.3651522595048486 1.1990682409889113 1.0923134152890148 1.0 15.916579684972064 REELFIVSK ddPTM_A459_Selumetinib_30min_R1 2 REELFIVSK 9 1 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 ; 127.83 0.0060473 21519000.0 8952.7 14650.3 9760.3 13481.3 8959.5 10166.5 10214.1 7428.0 5415.299999999999 7381.9 False True 9161.280491078282 12935.0360652603 8434.904869490247 11127.044030342999 8149.114806928196 10064.234240443435 9443.642213580912 7230.985310455564 9189.368582136807 8329.43877079508 1.0998676793447153 1.5529300858316528 1.0126618493271067 1.3358695989646943 0.9783510067329938 1.2082727921274776 1.1337669287746595 0.8681239528176923 1.1032398262361731 1.0 13.024003576187132 -6.401541340549445 0.5415326207052836 0.9935860940369512 1.3138173127943684 0.24371751873379666 0.16298757447745613 1.4026559212386345 0.8567584417095854 0.12425932796656514 0.22316796971607245 3.966967655165055e-07 6.401541340549445 0.3202312187574172 REELITNWEQIR ddPTM_A459_Selumetinib_30min_R2 1 REELITNWEQIR 12 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 122.52 0.004765 1459300.0 5469.3 7604.0 7537.3 6061.4 7840.4 8755.7 6852.4 3785.0 5103.5 6754.9 False True 5165.338201342618 8187.202349286336 7052.358323991748 5235.826863501777 6855.41885793468 9961.718198668968 7171.050177773003 3796.0137233595187 6124.342603704278 6559.868485662065 0.7874149020872174 1.248074159898349 1.0750761755980505 0.7981603404009925 1.045054313652568 1.5185850479231928 1.0931698087311965 0.5786722297339472 0.9336075284268706 1.0 12.679451176184552 -7.714449363562391 24.11290640150643 0.8171048920459728 1.091598738298316 0.1991926682554399 0.22175465488019652 119.79939537240581 61474.64828221707 0.10697470061306477 0.06176151163425361 1.9299703473978493e-08 7.714449363562391 0.2744938462523433 REEQTDTS(ph)DGESVTHHIR ddPTM_A459_Selumetinib_30min_R1 1 REEQTDTSDGESVTHHIR 18 1 A2AB27;P36915 A2AB27 GNL1 Guanine nucleotide-binding protein-like 1 1 REEQT(0.002)DT(0.036)S(0.955)DGES(0.008)VTHHIR 65.111 0.023373 5936700.0 607.9 724.81 1023.6 1189.3 1443.9 782.66 921.16 709.02 339.82 524.28 True False 622.0628872325092 639.9489082449726 884.6007422323298 981.611080925944 1313.2994999412492 774.7871509984224 851.676159569829 690.2144863784603 576.649720529191 591.5764449196606 1.0515342396991294 1.081768744750953 1.4953278647740336 1.6593140064243974 2.2199996487683054 1.3096991228304278 1.4396721960176952 1.1667376081415737 0.9747678858435671 1.0 9.208420798881518 -7.876904287026635 2.0450624880491803 0.9834214594781263 1.4914007337547437 0.2882588108375329 0.3088545568148696 0.48426286941970753 3.860488022729973 0.2652618415169617 0.09880906543832714 1.3276870308032581e-08 7.876904287026635 0.5079792742766174 REESPMDVDQPS(ph)PSAQDTQSIASDGTPQGEK ddPTM_A459_Selumetinib_30min_R1 3 REESPMDVDQPSPSAQDTQSIASDGTPQGEK 31 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 REESPMDVDQPS(0.492)PS(0.492)AQDT(0.011)QS(0.004)IASDGTPQGEK;REES(0.001)PMDVDQPS(0.372)PS(0.372)AQDT(0.239)QS(0.014)IAS(0.001)DGTPQGEK;REESPMDVDQPS(0.807)PS(0.191)AQDT(0.001)QS(0.001)IASDGTPQGEK 81.847 4.9427e-06 52732300.0 923.47 1325.3600000000001 1089.35 1106.36 1246.76 1046.8700000000001 1220.3 1280.17 840.77 1155.2399999999998 True False 944.9850542401799 1170.1862350568526 941.4222533712275 913.1549949493216 1133.9907781333563 1036.3394382819079 1128.251788530833 1246.215733021795 1426.7252825888052 1303.5263069905182 0.724945134726041 0.8977081849299146 0.7222119326035784 0.7005267097812119 0.869940845882449 0.7950276359780795 0.8655381809176176 0.9560342022547765 1.0945120746221988 1.0 10.348203983440264 -7.7433656388488705 1.601084923417311 1.0489187745678787 0.7847149133436457 0.733582988434158 0.06367332936546621 0.20339227252895808 0.9881879272145649 0.04887918730174179 0.019468878216013324 1.805653280097666e-08 7.7433656388488705 -0.264203861224233 REESPMDVDQPS(ph)PSAQDTQSIASDGTPQGEK ddPTM_A459_Selumetinib_30min_R2 2 REESPMDVDQPSPSAQDTQSIASDGTPQGEK 31 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 REESPMDVDQPS(0.5)PS(0.5)AQDTQSIASDGTPQGEK;REESPMDVDQPS(0.487)PS(0.487)AQDT(0.024)QS(0.001)IASDGTPQGEK 120.93 2.6594000000000004e-16 8456900.0 57508.0 46278.0 56124.0 60797.0 63075.0 42098.0 45917.0 49556.0 40795.0 49639.0 True False 54311.93558276405 49827.37379277657 52513.0429431909 52516.34371932514 55150.95460234554 47896.61737240496 48052.23148280938 49700.19975556255 48955.13990753718 48205.793092389125 1.1266682300750068 1.0336387101292908 1.0893512910895726 1.0894197636926044 1.1440731718000288 0.9935863368248788 0.9968144573560809 1.0310005617023934 1.0155447461202824 1.0 15.55691891113857 -6.777772977074037 24.999994121156895 1.0086658152109274 1.092325741702861 0.7045269966387953 0.028823212446005476 147.27650758807061 225418.19231354524 0.010303310445369163 0.009112955521192108 1.6681189765334668e-07 6.777772977074037 0.08365992649193355 REESPMDVDQPS(ph)PSAQDTQSIASDGTPQGEKEK ddPTM_A459_Selumetinib_30min_R2 2 REESPMDVDQPSPSAQDTQSIASDGTPQGEKEK 33 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 REESPMDVDQPS(0.401)PS(0.099)AQDT(0.401)QS(0.099)IASDGTPQGEKEK;REESPMDVDQPS(0.623)PS(0.355)AQDT(0.017)QS(0.004)IASDGTPQGEKEK 73.13 1.3148e-05 17455800.0 45507.0 51123.0 50132.0 53790.0 48955.0 27659.0 30890.0 26761.0 20658.2 48042.0 True False 42977.903118954615 55043.96971364618 46906.56169959458 46463.70920707437 42804.835236747145 31468.7761865967 32326.4462073738 26838.87007947796 24790.41723833519 46654.90263189347 0.9211872856760558 1.1798110511116555 1.005394054075875 0.995901964980452 0.9174777530772424 0.6745009508407916 0.6928842283184901 0.5752636607397141 0.5313571744845603 1.0 15.509741071153412 -6.6101821730403385 1.9995149549824756 0.6603647008199771 1.0399503901272475 0.5754399160064102 0.13334790581299366 0.20877381237799664 1.7028584125879829 0.048615412161057144 0.04954702788427357 2.453679457497955e-07 6.6101821730403385 0.37958568930727044 REESPMDVDQPSPS(ph)AQDTQSIASDGTPQGEK ddPTM_A459_Selumetinib_30min_R2 3 REESPMDVDQPSPSAQDTQSIASDGTPQGEK 31 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 REESPMDVDQPS(0.191)PS(0.809)AQDT(0.001)QSIASDGTPQGEK;REESPMDVDQPS(0.236)PS(0.755)AQDT(0.008)QS(0.001)IASDGTPQGEK;REESPMDVDQPS(0.242)PS(0.757)AQDT(0.001)QSIASDGTPQGEK 110.46 1.2144e-11 42112700.0 124758.0 110063.0 129410.0 145021.0 141100.0 107400.0 110123.0 123352.0 94809.4 120958.0 True False 117824.44980584393 118504.47819167572 121083.90149095455 125268.88962482147 123373.75654999542 122193.37511986999 115243.9377045849 123710.93389797708 113773.92919597146 117465.62825337365 1.0030546940224616 1.0088438631261671 1.0308028253999226 1.066430167594355 1.0502966560045797 1.0402479170868484 0.981086462637423 1.0531670901306747 0.9685720911530036 1.0 16.84187914439569 -8.267799241708907 24.95130596082277 0.9842860436266112 1.0293165641395816 0.3343690632486801 0.025371150232058763 649.5942743023364 2548479.9471502486 0.023292723819475877 0.006635637759263367 5.397600759922371e-09 8.267799241708907 0.04503052051297041 REFITGDVEPTDAES(ph)EWHSENEEEEK ddPTM_A459_Selumetinib_30min_R2 1 REFITGDVEPTDAESEWHSENEEEEK 26 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 REFITGDVEPT(0.018)DAES(0.819)EWHS(0.163)ENEEEEK 71.54 0.00043558 9057800.0 27990.0 18911.0 28302.0 34226.0 30654.0 33366.0 35861.0 32752.0 30208.0 25973.0 True False 26434.42785284769 20361.41289155102 26481.08013288769 29564.359756856797 26802.970469762986 37961.86363360881 37528.60755722343 32847.30289761452 36250.44408204148 25223.092004041657 1.0480248753250367 0.8072528494241856 1.0498744614119657 1.1721148125741092 1.0626361932735358 1.505044013934768 1.487867052588556 1.3022710654328655 1.4371927151608868 1.0 14.622457520618779 -6.192179179031839 1.2835029989291968 1.3630966549343586 0.9434049809806481 0.46920976012555915 0.16299723944589567 0.35032149691179676 1.1726351377393176 0.06192414634133334 0.09476530084469995 6.424226151438344e-07 6.192179179031839 -0.41969167395371054 REFITGDVEPTDAESEWHS(ph)ENEEEEK ddPTM_A459_Selumetinib_30min_R1 1 REFITGDVEPTDAESEWHSENEEEEK 26 1 E9PNJ7;C9J6D1;Q99733;Q99733-2;E9PS34;A8MXH2;E9PKT8;C9JZI7 E9PNJ7 NAP1L4 Nucleosome assembly protein 1-like 4 1 REFITGDVEPT(0.001)DAES(0.28)EWHS(0.72)ENEEEEK 75.10600000000002 0.00010179 6578700.0 652.56 549.61 182.72 325.05 553.32 398.03 553.21 484.78 74.164 250.91 True False 667.7633783392764 485.26140569324326 157.90762760911628 268.28611944419265 503.2723036965802 394.02617958232423 511.48092430807407 471.9220596126343 125.85089127575462 283.1167425703673 2.3586149384058666 1.713997559055109 0.5577474019215557 0.9476165803847203 1.7776140652349244 1.3917445362115626 1.806607831329325 1.6668814967569088 0.4445194238008548 1.0 8.14525325766558 -8.256633505558305 24.96923658529815 0.7222596861348443 1.495260050849888 0.3052170626791735 0.4840641739364225 498.5683280462427 2590380.2579301763 0.3744102048380784 0.13126029936305406 5.53817269959565e-09 8.256633505558305 0.7730003647150436 REGGDGEEQDVGDAGR ddPTM_A459_Selumetinib_30min_R1 2 REGGDGEEQDVGDAGR 16 1 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 ; 180.56 1.3659e-06 5338930.0 890.76 898.44 841.9499999999999 1176.56 1236.2 661.8199999999999 890.36 750.96 439.35 734.24 False True 911.5129748827608 793.2502271265756 727.6178145003034 971.095882766525 1124.3859282688363 655.1626916844812 823.1994283670516 731.0421013381401 745.544861145607 828.4868561032497 1.1002141653399555 0.9574686928137787 0.878249074369895 1.1721319120668134 1.3571560248491261 0.7907943099616681 0.9936179702825133 0.8823822562213762 0.899887373774695 1.0 9.694334999128417 REGGDGEEQDVGDAGR ddPTM_A459_Selumetinib_30min_R2 1 REGGDGEEQDVGDAGR 16 1 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 177.04 1.5976e-06 5221900.0 12615.0 12422.0 16224.0 15152.0 16172.0 11503.0 12403.0 11819.0 11356.0 14515.0 False True 11913.90880184615 13374.727456974595 15180.165503355596 13088.271461342087 14140.32878048564 13087.433836162621 12979.76407607825 11853.391333259216 13627.517313150924 14095.91423550089 0.8452029859716862 0.9488371760442491 1.0769195420559523 0.9285152592925806 1.003150880761809 0.928455836032374 0.9208174694613572 0.8409097228618327 0.9667707312541461 1.0 13.782989431083157 -6.972971509310196 22.799261837620925 0.9196911851219368 0.9646878733235007 0.030896200582466005 0.06692194561663005 210.63219401496826 177671.51053505298 0.023673381821910016 0.020876983920333568 1.0642128306773732e-07 6.972971509310196 0.044996688201563884 REGPGS(ph)EPDSQVDGGLSGASLGEK ddPTM_A459_Selumetinib_30min_R2 1 REGPGSEPDSQVDGGLSGASLGEK 24 1 Q5JSZ5;A0A494C0D3;H0Y412;A0A494C065 Q5JSZ5 PRRC2B Protein PRRC2B 1 REGPGS(0.886)EPDS(0.114)QVDGGLSGASLGEK 58.515 0.0056 8111200.0 12759.0 12668.0 13156.0 12112.0 14173.0 10214.0 12638.0 11486.0 9751.4 12377.0 True False 12049.905858323824 13639.594865959929 12309.557283169761 10462.324705634599 12392.461031772387 11620.885786539597 13225.692041721915 11519.422358390342 11701.952476880937 12019.643850692 1.0025177125052738 1.1347752924621526 1.0241199686179612 0.8704355000528786 1.0310173234508044 0.966824469251687 1.1003397609788979 0.9583830021491977 0.9735689860899852 1.0 13.553106528306309 -5.518859182195025 24.996650249789994 0.9866472007910125 1.0713467970251904 0.2215553504519301 0.0622106300254854 220.69158516190654 1372422.0800113245 0.01649030343156935 0.02944192383025724 3.0278950487150894e-06 5.518859182195025 0.08469959623417789 REGPGSEPDS(ph)QVDGGLSGASLGEK ddPTM_A459_Selumetinib_30min_R2 1 REGPGSEPDSQVDGGLSGASLGEK 24 1 Q5JSZ5;A0A494C0D3;H0Y412;A0A494C065 Q5JSZ5 PRRC2B Protein PRRC2B 1 REGPGS(0.464)EPDS(0.536)QVDGGLSGASLGEK 101.0 2.4808e-06 9678100.0 51415.0 44604.0 53318.0 54453.0 51626.0 42484.0 35147.0 42441.0 31567.0 48787.0 True False 48557.56013055247 48024.98337553496 49887.57792824911 47036.40746333559 45140.280337704164 48335.785368645826 36781.405142459254 42564.496283514214 37881.28205567411 47378.392546151015 1.0248882986743975 1.0136473779424684 1.0529605427126705 0.992781834409382 0.952760908756735 1.0202073724126925 0.7763329054828254 0.8983946899855749 0.7995476422880784 1.0 15.53194163120829 -7.242908546177298 24.825360393080487 0.8601016999707697 1.0083586317114461 0.558394615371808 0.06122627343559399 507.56019230803514 679968.477117113 0.0220751579292814 0.017065909118795665 5.7159899143425205e-08 7.242908546177298 0.14825693174067645 REGPVGGES(ph)DSEEMFEK ddPTM_A459_Selumetinib_30min_R1 3 REGPVGGESDSEEMFEK 17 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 REGPVGGES(0.84)DS(0.16)EEMFEK;REGPVGGES(0.755)DS(0.245)EEMFEK;REGPVGGES(0.976)DS(0.024)EEMFEK 225.5 1.0648e-12 100313800.0 7779.1 9524.800000000001 10228.0 10484.599999999999 8842.6 8364.199999999999 9396.8 8054.4 5105.3099999999995 6439.549999999999 True False 7960.337894506351 8409.631988040608 8839.09377838245 8653.661430317125 8042.788391287833 8280.063742085968 8687.991810592912 7840.771147621599 8663.33819291061 7266.12896902876 1.0955404078893447 1.157374445717373 1.2164790655462234 1.1909589641475675 1.1068876461688908 1.1395426336883112 1.1956836780113205 1.0790850507941987 1.1922907272685817 1.0 12.826971257534527 -13.635775518938647 0.38131778827986956 1.5144245150785803e-10 1.1568687793819206 0.5049750581448257 0.04499515942924613 238.58928433758774 3.505443458146394 192.77448563585375 0.03024128184901833 2.3132601747330455e-14 13.635775518938647 1.1568687792304782 REGPVGGES(ph)DSEEMFEK ddPTM_A459_Selumetinib_30min_R2 6 REGPVGGESDSEEMFEK 17 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 REGPVGGES(0.915)DS(0.085)EEMFEK;REGPVGGES(0.994)DS(0.006)EEMFEK;REGPVGGES(0.645)DS(0.355)EEMFEK;REGPVGGES(0.943)DS(0.057)EEMFEK;REGPVGGES(0.952)DS(0.048)EEMFEK;REGPVGGES(0.996)DS(0.004)EEMFEK 154.66 3.7996e-05 128249800.0 284243.0 265728.0 276478.0 291273.0 297722.0 242098.0 246135.0 235420.0 200302.0 275461.0 True False 268445.91197488335 286108.48314981 258689.70648648558 251601.11492604853 260319.50069154994 275444.8019531685 257580.76520724964 236105.0332241211 240367.99690549116 267507.7251963697 1.003507139010004 1.0695335356755997 0.9670363960389889 0.9405377535970425 0.9731289087089239 1.029670458118443 0.9628909408809299 0.8826101491117807 0.8985460017240398 1.0 18.029221029283548 -7.541925546289787 7.257725520906435 0.918481392088071 0.9955936542641608 0.3340679003195858 0.04401707404836053 0.1799188062637163 42.65175967687838 0.021278581718445117 0.01248661777370205 2.8712727793628624e-08 7.541925546289787 0.0771122621760898 REGPVGGESDS(ph)EEMFEK ddPTM_A459_Selumetinib_30min_R1 3 REGPVGGESDSEEMFEK 17 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 REGPVGGES(0.082)DS(0.918)EEMFEK;REGPVGGES(0.035)DS(0.965)EEMFEK;REGPVGGES(0.401)DS(0.599)EEMFEK 154.74 0.00012657 41179800.0 3709.6 4120.54 4692.8 4808.5 4532.900000000001 3286.8399999999997 3858.48 3847.2 2084.34 2822.86 True False 3796.0264623749244 3638.1052612129224 4055.543535705237 3968.785741724044 4122.899995348497 3253.7773738119436 3567.4317471199297 3745.1597585332024 3536.9727458296 3185.201577984882 1.191769616281705 1.1421899594544875 1.273245487424057 1.2460077155414748 1.2943921740604092 1.021529499514579 1.1200018773621434 1.1757999193578756 1.1104392168696795 1.0 11.63716896212222 -6.758534509934107 24.99999913830868 1.0986945843244034 1.2280143326036699 0.5747724467747155 0.06139008146164199 65.70992828006639 565515.5352732299 0.021582430708752053 0.02068439063780286 1.7436747959697482e-07 6.758534509934107 0.1293197482792665 REGT(ph)PPPPPPSR ddPTM_A459_Selumetinib_30min_R1 1 REGTPPPPPPSR 12 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 REGT(1)PPPPPPSR 99.796 0.017519 46609000.0 1424.0 1617.1 2056.2 1880.2 1759.9 1492.3 1346.3 1688.4 1086.1 1465.9 True False 1457.1764293783415 1427.7691802306056 1776.9793338981221 1551.8583657251822 1600.7173557355802 1477.2888168999891 1244.747507087651 1643.6181473038725 1843.0323743945455 1654.0625440751717 0.8809681560095334 0.8631893548069596 1.0743120568585733 0.9382102093321179 0.9677489895828467 0.8931275435693871 0.7525395648104836 0.9936856095262475 1.114245879635121 1.0 10.69179807196518 -7.995756672299415 24.999888664025974 1.0560705769228798 0.9140393170154703 0.3526298546080504 0.08116863933783952 129.5720092315557 763384.4157893764 0.04678832889944423 0.022333642145136685 1.00981851148537e-08 7.995756672299415 -0.1420312599074095 REPAEQPGDGER ddPTM_A459_Selumetinib_30min_R1 1 REPAEQPGDGER 12 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 0 112.02 0.008864499999999999 1996400.0 673.41 817.79 829.94 999.32 1126.0 731.76 856.35 606.43 520.64 535.58 False True 689.0991427722389 722.0427666197435 717.2387065340956 824.807521559669 1024.1534988114463 724.3991587849205 791.7548300486599 590.3455064377446 883.4880539589134 604.3269099909816 1.1402754558497525 1.194788374773049 1.1868389354774869 1.3648366602969537 1.6947011325819163 1.1986875758945283 1.310143263454006 0.9768645027681365 1.461937304714923 1.0 9.239185374814388 -11.815698404570602 0.47520249300933864 0.6090104414428203 1.2841764228417178 0.1651917647618244 0.18684885378923255 187.87918970377416 11.35977873304123 77.54994854174102 0.09786282955764006 1.5286272436002586e-12 11.815698404570602 0.6751659813988975 REPAEQPGDGER ddPTM_A459_Selumetinib_30min_R2 1 REPAEQPGDGER 12 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 0 95.018 0.024926 3105200.0 8691.7 7358.8 8462.3 8530.5 9937.6 6828.8 6517.4 8922.9 7300.3 9874.7 False True 8208.650109631884 7923.196297728606 7917.844831055595 7368.631184066704 8689.1498447288 7769.405214325599 6820.4720139831015 8948.86416173438 8760.56398742477 9589.591753448203 0.8559957838330539 0.8262287385570508 0.8256706890789709 0.7683988404842269 0.9061021645269075 0.8101914465265838 0.7112369524521847 0.9331851023289462 0.913549211756034 1.0 13.227253683032455 -7.9049381228179945 10.201934578281856 0.9456439482495244 0.8172819286387821 0.5816271464714928 0.052164812054106016 0.24697614599032192 24.19241862460687 0.028511775584725865 0.013681730960939331 1.244691939705532e-08 7.9049381228179945 -0.12836201961074223 REPEDEGEDDD ddPTM_A459_Selumetinib_30min_R1 2 REPEDEGEDDD 11 1 P39687 P39687 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 ; 158.76 0.0011126 1160300.0 801.28 970.46 912.51 917.86 1060.8600000000001 965.27 946.53 935.5899999999999 526.65 856.02 False True 819.948264980531 856.8380920453855 788.5961540586399 757.5729813660868 964.9054003100458 955.5602601950368 875.1324800443248 910.7751139753798 893.6865850058815 965.8985053409018 0.8488969187203996 0.8870891582371536 0.8164379069831097 0.7843194467918871 0.9989718329354847 0.9892967583149782 0.906029438088278 0.9429304517392675 0.9252386043298265 1.0 9.915727791326297 -6.264260415232799 24.9997835973984 0.9562828962219725 0.8366969533397809 0.7267013596666632 0.03785887435697903 147.8632131316646 1310349.1050529582 0.01234523358961877 0.01463176792925513 5.441762515483113e-07 6.264260415232799 -0.1195859428821916 REPES(ph)PPASAPIPLFGADTIGQR ddPTM_A459_Selumetinib_30min_R1 2 REPESPPASAPIPLFGADTIGQR 23 1 Q96AY4 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 REPES(0.987)PPAS(0.013)APIPLFGADTIGQR;REPES(1)PPASAPIPLFGADTIGQR 112.35 6.9318e-06 12576600.0 3542.4 4446.7 3472.5 3706.3 3720.2 3605.3999999999996 4116.9 3679.4 2095.6099999999997 3509.1 True False 3624.931027689491 3926.0782967852565 3000.9535730771468 3059.064280867593 3383.7085668546565 3569.13294944128 3806.3589184647935 3581.8103596244214 3556.0971127013668 3959.5271665285363 0.9154959355582859 0.9915523070466503 0.7579070547729551 0.7725832283023802 0.8545738984842675 0.9014038291270193 0.9613165305800816 0.9046055776313127 0.8981115580573548 1.0 11.951112443443455 -6.925782317519727 3.79355487095337 0.9330929075026784 0.8557154003276022 0.24442916566538353 0.06773192185524941 0.3986202167168999 11.379003704845033 0.027678550544570777 0.02385636951079006 1.1863632429006381e-07 6.925782317519727 -0.07737750717507619 REPGYT(ph)PPGAGNQNPPGMYPVTGPK ddPTM_A459_Selumetinib_30min_R2 1 REPGYTPPGAGNQNPPGMYPVTGPK 25 1 C9JXK9;C9JUT4;A0A087WZF1;Q93052 C9JXK9 LPP Lipoma-preferred partner 1 REPGY(0.136)T(0.864)PPGAGNQNPPGMYPVTGPK 86.492 0.00010899 7086000.0 33035.0 33182.0 34943.0 45083.0 43615.0 31287.0 29448.0 38361.0 35125.0 36920.0 True False 31199.046949582833 35726.95270305357 32694.805423061774 38942.61762748714 38135.69377695283 35596.500254891784 30817.390350105 38472.62415899456 42150.9814745004 35854.023670319875 0.8701686381550963 0.9964558798634504 0.9118866469128452 1.0861435800223453 1.0636377698529198 0.9928174472746479 0.859523902630091 1.0730350521535013 1.175627646762368 1.0 15.12984741210227 -3.3581659241152293 0.6690075679647837 1.0294467678982764 3.9409583941409494e-11 0.24233607710139293 0.08348125190691211 30.124608254660142 2.2880855026072764 0.03668449178420555 36.146337596978924 0.00043836318719598136 3.3581659241152293 -1.0294467678588668 REPLPSR ddPTM_A459_Selumetinib_30min_R1 2 REPLPSR 7 1 H3BT71;H0Y6E7;Q8IZ40;P38159;P38159-2;H3BUY5;Q96E39 H3BT71;P38159 RBMX;RCOR2;RBMXL1 REST corepressor 2;RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 ; 157.33 0.0016902999999999998 11498500.0 7677.0 10505.0 7925.2 9598.7 9663.0 9273.599999999999 10090.900000000001 7769.5 5043.7 8561.5 False True 7855.859163158374 9275.069716357992 6849.001370007486 7922.467234914537 8788.983356141209 9180.316003755099 9329.735288769805 7563.42762110723 8558.790522726978 9660.451921072094 0.8131978946060061 0.9601072281232023 0.7089731853090575 0.8200928175661704 0.9097900831088478 0.9502988140472304 0.9657659253413492 0.782926894404321 0.8859617120041673 1.0 13.237874965342106 -6.264201534622494 23.511104519499494 0.9091611019313347 0.826870982121172 0.2384209527144736 0.07842607385543536 183.37679801986187 1560882.3835726026 0.024549810562190588 0.029128979440719346 5.442500346684953e-07 6.264201534622494 -0.08229011981016265 REQEELER ddPTM_A459_Selumetinib_30min_R1 1 REQEELER 8 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 0 105.4 0.019174 1102600.0 446.56 605.42 650.46 661.1 611.83 639.54 549.26 497.76 373.31 531.3 False True 456.9639791454996 534.5371449478777 562.131104721025 545.6512953839585 556.4900845273602 633.1068082558594 507.82887598823703 484.5577878476519 633.4798045163685 599.4975303002514 0.7622449735808494 0.8916419466818503 0.9376704261642049 0.910181056310066 0.9282608457930571 1.0560624126988067 0.8470908557936792 0.8082732010671784 1.0566845941785574 1.0 9.227610000076577 -4.672421456663647 1.9510905779927246 0.9356472676450227 0.6725231382970324 0.3363195283565713 0.07623185366912325 1.3690537184310354 4.414717397161291 0.020501354485314992 0.7193732502303862 2.1260748168535456e-05 4.672421456663647 -0.26312412934799034 REQGGSGLGSGSS(ph)GGGGSTSGLGSGYIGR ddPTM_A459_Selumetinib_30min_R1 2 REQGGSGLGSGSSGGGGSTSGLGSGYIGR 29 1 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 REQGGSGLGSGS(0.403)S(0.597)GGGGSTSGLGSGYIGR;REQGGSGLGSGS(0.115)S(0.885)GGGGSTSGLGSGYIGR 163.27 1.4209000000000002e-19 37074000.0 1793.26 2374.07 2432.3 2617.25 2362.06 2021.21 1950.81 1911.21 1134.11 1442.63 True False 1835.039468923458 2096.1127807248 2102.0070196675442 2160.196419367214 2148.4120900555636 2000.8784625118453 1803.6588310938575 1860.5185023149936 1924.5018378828809 1627.8056129061763 1.127308724318317 1.2876923166412597 1.2913132888851269 1.3270604316878736 1.319821035768473 1.22918759257723 1.1080308464311808 1.1429611051612896 1.182267601625358 1.0 10.66871271274273 -7.133716021171595 3.7093852732895822 1.1201551952911037 1.2758948947010862 0.5578593071412725 0.06802764879159238 0.19568727350093226 4.801964185435553 0.027484055884147266 0.020879548209899765 7.349943131249562e-08 7.133716021171595 0.15573969940998245 REQGGSGLGSGSS(ph)GGGGSTSGLGSGYIGR ddPTM_A459_Selumetinib_30min_R2 2 REQGGSGLGSGSSGGGGSTSGLGSGYIGR 29 1 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 REQGGSGLGS(0.001)GS(0.181)S(0.797)GGGGS(0.013)T(0.004)S(0.005)GLGSGYIGR;REQGGSGLGSGS(0.18)S(0.819)GGGGS(0.001)TSGLGSGYIGR 116.35 7.165199999999998e-09 7612400.0 5725.700000000001 5900.34 9375.9 8312.5 7518.1 3494.7 3912.6 3778.2000000000003 3458.2999999999997 6201.3 True False 5407.488515793146 6352.877105416637 8772.664801708064 7180.323160137675 6573.609065333237 3976.063203271974 4094.5436526698168 3789.1939364853206 4150.056632975508 6022.252356087612 0.8979179542894727 1.0549005139239662 1.456708268433851 1.1922986177886459 1.0915532389950886 0.6602285935847173 0.679902370502763 0.6291987968014995 0.6891203469380375 1.0 12.556087448594486 -6.702433650764789 4.964172904967698 0.7047258299515616 1.1614444578831018 0.6065589170292167 0.16325495025339498 0.13315906174482922 6.605250554362879 0.057083252446372405 0.056009314763756354 1.9841127560329374e-07 6.702433650764789 0.45671862793154017 REREES(ph)EDELEEANGNNPIDIEVDQNK ddPTM_A459_Selumetinib_30min_R1 1 REREESEDELEEANGNNPIDIEVDQNK 27 2 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 REREES(1)EDELEEANGNNPIDIEVDQNK 79.021 0.00012833 3635800.0 219.48 337.78 298.32 152.8 162.59 247.49 148.98 134.35 0.0 77.318 True False 224.59345696626283 298.2325605703381 257.8097825544635 126.11634841123707 147.883763207596 245.0004753029407 137.74231865551386 130.7866015696964 0.0 87.24251844109699 2.5743577899794383 3.4184313554828654 2.955093309560147 1.445583537302242 1.6950881961006408 2.8082691751769664 1.5788439068103302 1.4991153844097107 0.0 1.0 6.446959511932037 -6.838752775867356 0.41742182593309557 0.5965313137951155 3.2158976560837944 0.5884633290760288 0.6295587584206396 1.0137848784442909 0.373862111763075 0.6828130375991027 1.0357725712322017 1.4495968083726885e-07 6.838752775867356 2.619366342288679 REREES(ph)EDELEEANGNNPIDIEVDQNK ddPTM_A459_Selumetinib_30min_R2 3 REREESEDELEEANGNNPIDIEVDQNK 27 2 Q9UKL0 Q9UKL0 RCOR1 REST corepressor 1 1 REREES(1)EDELEEANGNNPIDIEVDQNK;REREES(1)EDELEEANGNNPIDIEVDQNK;REREES(1)EDELEEANGNNPIDIEVDQNK 75.956 5.451e-05 11010500.0 32802.4 29653.9 33260.5 36909.6 34606.6 26220.4 25848.6 29121.0 22226.2 33515.6 True False 30979.373926411263 31928.25877768306 31120.555641294282 31882.448807388584 30259.00952107066 29832.02209490729 27050.611118029206 29205.737288758934 26672.06105191576 32547.91754401333 0.9518081728122549 0.9809616463021842 0.9561458301966975 0.9795541838974842 0.9296757459260653 0.9165570133501342 0.8311011320908528 0.8973150816566101 0.8194705856633725 1.0 14.990277620481566 -6.725725544580585 2.101668253251709 0.8787998055451947 0.966569359409747 0.34796466642489865 0.047235447228112466 0.29875318168048903 2.7134793900686858 0.017192217620488334 0.016201200954128702 1.8805048394909385e-07 6.725725544580585 0.08776955386455232 RES(ph)AASGLGGLLEEEGAGAGAAQEEVLEPGR ddPTM_A459_Selumetinib_30min_R2 1 RESAASGLGGLLEEEGAGAGAAQEEVLEPGR 31 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RES(0.5)AAS(0.5)GLGGLLEEEGAGAGAAQEEVLEPGR 101.34 9.8198e-09 4042600.0 7538.8 5164.8 4430.5 5890.3 7396.8 5794.9 3986.1 5024.0 6232.9 6350.4 True False 7119.82367620751 5560.923552550507 4145.446453563665 5088.030978665739 6467.547855768995 6593.094874135338 4171.461548307307 5038.61900823203 7479.654161776892 6167.047451679283 1.1544947127443923 0.9017157069281625 0.6721930528416581 0.8250351596176339 1.048726786431307 1.0690845053154314 0.6764114563722743 0.8170229024036482 1.2128419994141908 1.0 12.590364231681603 -8.25596702366596 24.995964786217463 1.1064210042666132 0.8895739822704759 0.21896632120338433 0.1589517500314563 643.7999236142198 2940704.839833513 0.11973493396361537 0.04229868098835074 5.546678277393013e-09 8.25596702366596 -0.21684702199613726 RES(ph)CGSSVLTDFEGKDVATK ddPTM_A459_Selumetinib_30min_R2 2 RESCGSSVLTDFEGKDVATK 20 2 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;H0Y704;O15231-9;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RES(0.953)CGS(0.039)S(0.009)VLTDFEGKDVATK;RES(0.971)CGS(0.013)S(0.013)VLT(0.003)DFEGKDVATK 89.04899999999998 0.0021382 10866700.0 46407.0 53009.0 42888.0 59252.0 46494.0 25526.0 26260.0 25938.0 18858.7 50002.0 True False 43827.884721940056 57074.61984920037 40128.63277292372 51181.775384598826 40653.00805836627 29041.974798042862 27481.142033202854 26013.475285732955 22630.966956104203 48558.3123392019 0.902582536554861 1.1753831033193285 0.8264008949200492 1.0540270639364657 0.8371997728089584 0.5980845173360115 0.5659410450930539 0.5357162148473571 0.46605752683529456 1.0 15.567430660653455 -6.603049873861012 3.021217743911469 0.5981848557492746 0.9902434581642084 0.5173335668633521 0.1606663710972144 0.18277582728068129 3.3720491141545117 0.05313295063176056 0.05388978118277507 2.4943082671044995e-07 6.603049873861012 0.39205860241493384 RES(ph)DESGESAPDEGGEGAR ddPTM_A459_Selumetinib_30min_R1 1 RESDESGESAPDEGGEGAR 19 1 Q7Z3C6;H7C152;Q7Z3C6-2 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 RES(0.986)DES(0.014)GESAPDEGGEGAR 99.078 0.00071643 1228400.0 343.46 355.19 475.76 430.07 382.73 321.64 234.43 183.39 350.57 257.68 True False 351.46194974317774 313.6041896766488 411.1544051626159 354.9663479137483 348.1121390764697 318.40459362575393 216.74675635932417 178.5259014653265 594.8916853802559 290.75573801575155 1.208787665350004 1.0785829776458598 1.4140887054147897 1.2208403876607867 1.1972666178564322 1.0950930695252676 0.7454599446205323 0.6140064601430324 2.0460187284353024 1.0 8.18366385309896 -6.769575288357514 4.019342935270058 1.0510814894940346 1.2287031916193765 0.020640856310014 0.36541377536315733 0.7893746307477253 28.54806265190696 0.1288604470960383 0.11965978497200756 1.6999052361808843e-07 6.769575288357514 0.1776217021253419 RES(ph)FLYR ddPTM_A459_Selumetinib_30min_R2 1 RESFLYR 7 1 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;P27815-7;B7Z6T1;V9GYP2;P27815-2;P27815-6;Q08493;Q08493-3;Q08493-2;P27815;Q08499-6;Q08499-7;Q08499-12;Q08499-9;Q07343-3;Q07343;E9PMG3 A0A1B0GW84;Q08499-6;Q08499-9;Q07343-3 PDE4D;PDE4A;PDE4C;PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4D;cAMP-specific 3,5-cyclic phosphodiesterase 4A;cAMP-specific 3,5-cyclic phosphodiesterase 4C;cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 RES(1)FLYR 73.985 0.029292 4816100.0 10884.0 8221.7 9635.2 11328.0 7950.0 7590.8 7941.5 8155.6 6728.0 8841.5 True False 10279.110852104119 8852.277953067789 9015.281722012558 9785.106858110024 6951.2499260982495 8636.363797578308 8310.795485783718 8179.331445767738 8073.787996026719 8586.22292202419 1.1971632865177035 1.0309862710833133 1.0499706103469322 1.139628792191107 0.8095818137062184 1.0058396894664245 0.9679221656901099 0.9526111213333688 0.9403189352697746 1.0 13.067807914275665 -6.23532475495632 24.997848961452195 0.9477596863933706 1.0953002781649772 0.575170319939672 0.06649290796309534 582.8794755510472 557953.0649153242 0.019063393380941377 0.024602945510563568 5.816680977073407e-07 6.23532475495632 0.1475405917716066 RES(ph)GAAEQVDNK ddPTM_A459_Selumetinib_30min_R1 2 RESGAAEQVDNK 12 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 RES(1)GAAEQVDNK;RES(1)GAAEQVDNK 160.63 0.00085217 8744200.0 2763.6000000000004 3829.7 3750.3 3898.5 2947.8 3020.9 2533.0 2767.6 1811.09 2354.6 True False 2827.986502970493 3381.3169436207727 3241.0298589233166 3217.7001589084266 2681.1720104763594 2990.512488757742 2341.9337706700007 2694.194257568231 3073.287453219979 2656.8358457462296 1.0644189807579896 1.2726856832477946 1.219883367695607 1.2111023584916538 1.0091598300170084 1.1255917423523742 0.8814747717363088 1.0140612420153148 1.156747210461089 1.0 11.375493377434474 -6.2596794044427435 24.95935295314917 1.0291116040018402 1.199774308664364 0.4584440711736084 0.08546215943842263 135.63388809961447 1923508.8510396478 0.02568369734042368 0.031462891880169326 5.499466939038881e-07 6.2596794044427435 0.17066270466252376 RES(ph)GAAEQVDNK ddPTM_A459_Selumetinib_30min_R2 1 RESGAAEQVDNK 12 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 RES(1)GAAEQVDNK 118.2 0.0096196 0.0 15032.0 10627.0 13766.0 13808.0 12356.0 11934.0 12227.0 11496.0 8358.0 13121.0 True False 14196.581617863747 11442.056728809292 12880.31054728754 11927.32657987141 10803.72881595848 13577.800173934167 12795.579727340868 11529.451456734745 10029.833542032009 12742.162637547855 1.1141422395622307 0.8979681906658852 1.0108417945735992 0.9360519810604728 0.8478724627264361 1.0655805109506218 1.0041921525656567 0.9048268951426217 0.7871374606753712 1.0 13.637322536396448 -4.75243780719356 24.97883023974021 0.941649379271727 1.1141425753909717 0.30198029171796437 0.07964058923794348 467.9818033762488 1298525.4882934606 0.020154980549708008 0.2400590817228554 1.7683254312832715e-05 4.75243780719356 0.17249319611924474 RES(ph)GEEFR ddPTM_A459_Selumetinib_30min_R2 2 RESGEEFR 8 1 D6REW6;A0A3B3IRQ7;P30533 D6REW6 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 1 RES(1)GEEFR;RES(1)GEEFR 67.726 0.040393 12100200.0 25278.0 21386.6 17647.1 22139.0 16977.3 17334.4 14299.3 15656.0 6901.6 16918.1 True False 23873.14995585153 23026.88345124239 16511.704798709714 19123.630008094817 14844.459795012308 19722.05625398395 14964.245783525404 15701.556368009673 8282.112846815995 16429.63049449725 1.4530545871891232 1.4015460334883822 1.0049955051782784 1.163972008652286 0.9035175684556106 1.2003956060113115 0.9108084194916833 0.9556853012165166 0.5040961115704891 1.0 14.004012413717478 -2.3194638718819776 0.3089231238732706 0.8261325439659828 4.594086357774784 0.5818397211164112 0.16786956249090523 23.800458986627664 0.533018021083959 0.1645021020867657 45.65751087370241 0.004792213167446272 2.3194638718819776 3.767953813808801 RES(ph)GS(ph)DS(ph)DLFHSPSDDMDS(ph)IIFPK ddPTM_A459_Selumetinib_30min_R1 1 RESGSDSDLFHSPSDDMDSIIFPK 24 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36 Q12802-4 AKAP13 A-kinase anchor protein 13 4 RES(0.948)GS(0.948)DS(0.948)DLFHS(0.1)PS(0.061)DDMDS(0.995)IIFPK 46.35 0.038865 0.0 509.12 531.83 836.86 948.36 461.18 692.02 541.63 593.65 411.26 296.75 True False 520.9815054249306 469.5630963589409 723.219008542935 782.7467289219944 419.4663504279422 685.0589071038868 500.7744130311856 577.904473553035 697.8781827580342 334.8407530897788 1.5559082955629449 1.4023475100506655 2.1598894455628663 2.337668643076195 1.252733863955542 2.045924520185887 1.4955599293402497 1.725908415329854 2.0842092138375894 1.0 8.387331317132775 -11.114488761012929 6.330871355187378 0.9979680757353038 1.7823671128869771 0.3206891365937353 0.34250691669937916 0.00985794343473361 0.0006359125979153001 0.3327825953176716 0.08057345958718716 7.682653371487005e-12 11.114488761012929 0.7843990371516734 RES(ph)HQIGDAY(ph)S(ph)NSDKS(ph)LT(ph)ELESK ddPTM_A459_Selumetinib_30min_R2 1 RESHQIGDAYSNSDKSLTELESK 23 2 Q8TAL6 Q8TAL6 FIBIN Fin bud initiation factor homolog 5 RES(0.999)HQIGDAY(0.936)S(0.854)NS(0.381)DKS(0.815)LT(0.804)ELES(0.212)K 45.88 0.044013 2563700.0 2302.6 2314.1 1964.9 3100.9 1116.3 1212.4 2944.2 1399.0 0.0 1332.6 True False 2174.630710038125 2491.5840289957264 1838.480473221362 2678.5520706491325 976.0604141513803 1379.3970949285892 3081.111133821623 1403.0708583830829 0.0 1294.124375489388 1.6803877210146538 1.925304921370873 1.4206366158014134 2.0697794751267296 0.7542245804482832 1.065892213340742 2.3808462248124065 1.084185480899002 0.0 1.0 10.337760562949907 -8.001993049422339 24.98482693595079 0.5140307418715724 1.5925744972011124 0.4464184015167584 0.4977648816963746 64.13157765375385 803943.957941248 0.2771305619115313 0.1298321621747479 9.954213482424552e-09 8.001993049422339 1.07854375532954 RES(ph)LGLESK ddPTM_A459_Selumetinib_30min_R1 1 RESLGLESK 9 1 Q96BH1 Q96BH1 RNF25 E3 ubiquitin-protein ligase RNF25 1 RES(1)LGLESK 107.09 0.0065656 8579900.0 6097.0 7012.0 7604.2 7445.3 6797.0 6900.8 6644.4 7161.7 4493.3 5538.9 True False 6239.048237303189 6191.0317802096415 6571.591406880697 6145.118120590208 6182.212550107819 6831.384217425078 6143.20755856287 6971.748451519867 7624.801922352462 6249.871768454847 0.9982681994843017 0.9905854087211532 1.0514761982877272 0.9832390724569157 0.9891743029531379 1.093043900821344 0.9829333762605584 1.1155026390635032 1.219993338237328 1.0 12.609610874290873 -7.816081029642559 7.2458976022317385 1.1272647235152806 1.014437735549928 0.3573420447836366 0.05989955809504048 0.21349418304255974 23.061452118845445 0.0310538236685166 0.01491506607349768 1.5272810751437814e-08 7.816081029642559 -0.11282698796535251 RES(ph)LGLESK ddPTM_A459_Selumetinib_30min_R2 3 RESLGLESK 9 1 Q96BH1 Q96BH1 RNF25 E3 ubiquitin-protein ligase RNF25 1 RES(1)LGLESK;RES(1)LGLESK;RES(1)LGLESK 99.844 0.0094693 21571200.0 208817.0 178615.0 182232.0 226415.0 182043.0 135397.0 157328.0 161181.0 138530.0 167945.0 True False 197211.78710068236 192314.19616225385 170507.39151919968 195576.88641233934 159173.13085493146 154046.70773840832 164644.06373951765 161650.01002504915 166239.87085160232 163095.99147648606 1.209176174811843 1.1791472887914616 1.045441950937109 1.1991520125161146 0.9759475350311098 0.9445155968815924 1.0094917860887758 0.9911341692806388 1.0192762516518963 1.0 17.315361798803828 -6.269028304621588 24.9971004540086 0.9883118720076275 1.151667252546944 0.7612784108942973 0.04606951293233614 291.37354341444325 959750.9200616712 0.01447727417772551 0.0167275591609097 5.382347025724402e-07 6.269028304621588 0.16335538053931653 RES(ph)LSTSSDLYK ddPTM_A459_Selumetinib_30min_R1 1 RESLSTSSDLYK 12 1 Q8TB72-3;Q8TB72;Q8TB72-4 Q8TB72-3 PUM2 Pumilio homolog 2 1 RES(0.997)LST(0.001)S(0.001)S(0.002)DLYK 145.52 0.0012229 9747200.0 1622.6 1694.5 1380.7 1337.6 1051.2 1741.7 1612.0 1735.3 973.86 1371.3 True False 1660.4034229700112 1496.1071522483217 1193.2085236422217 1104.013269861719 956.1191456044343 1724.1800793370721 1490.4055421713545 1689.274206951202 1652.569292079801 1547.3197125931376 1.0730836099718253 0.9669024055416515 0.7711454290481025 0.7135004232651533 0.6179195791424926 1.1143011139226915 0.9632175755543104 1.091742186958999 1.0680205768918154 1.0 10.595555606928697 -6.78796494834545 24.999916828531973 1.0479253050680035 0.826622226619544 0.4343364885406499 0.12492183346069233 238.64345329597234 224915.8188578608 0.04841385485674431 0.04270906471922534 1.6294275374798159e-07 6.78796494834545 -0.22130307844845953 RES(ph)LSTSSDLYK ddPTM_A459_Selumetinib_30min_R2 1 RESLSTSSDLYK 12 1 Q8TB72-3;Q8TB72;Q8TB72-4 Q8TB72-3 PUM2 Pumilio homolog 2 1 RES(0.995)LS(0.003)T(0.001)S(0.001)S(0.001)DLYK 126.56 0.006312 0.0 26523.0 19009.0 22176.0 26461.0 19626.0 16085.0 21922.0 21976.0 22073.0 24298.0 True False 25048.957839981405 20466.929176431346 20749.220303403203 22856.96615222895 17160.406421333864 18300.56274490792 22941.416437618904 22039.946521677346 26488.21677115008 23596.453606214283 1.0615560396493053 0.8673731026700234 0.8793363888350899 0.9686610765191179 0.727245149110651 0.7755641186728307 0.9722400162529986 0.934036397565818 1.1225507533121093 1.0 14.526282427730353 -7.902868073307698 2.080072043201044 1.0537450282990213 0.8798767012246995 0.31319311813216955 0.09594036907735644 0.4006443271305337 3.286076502300222 0.07651839175602453 0.027959267115931583 1.250638882139138e-08 7.902868073307698 -0.17386832707432176 RES(ph)LSYIPK ddPTM_A459_Selumetinib_30min_R2 1 RESLSYIPK 9 1 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 RES(0.992)LS(0.008)YIPK 98.182 0.035785000000000004 4037300.0 22722.0 24736.0 27620.0 29995.0 28250.0 23966.0 26606.0 27653.0 22418.0 28678.0 True False 21459.20220337282 26633.17166122395 25842.959270382238 25909.629255738895 24700.982441795666 27267.09895831292 27843.231718788826 27733.465651799394 26902.22641125549 27849.99162560761 0.7705281384588079 0.956308067135474 0.9279341846056449 0.9303280806704235 0.886929618286977 0.97907027495266 0.9997572743679906 0.9958159422316999 0.965968922824355 1.0 14.765389273301608 -4.156967481218492 1.6600061897505747 0.9607415381191398 4.171918215858124e-14 0.7129461527108072 0.03574601051907111 4.293024155680324 2.5816399836227615 0.010833639010870524 11.071952174984371 6.966786775493674e-05 4.156967481218492 -0.960741538119098 RES(ph)PSPAPK ddPTM_A459_Selumetinib_30min_R1 2 RESPSPAPK 9 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RES(0.998)PS(0.002)PAPK;RES(1)PSPAPK 139.32 0.0042915 22662000.0 5939.5 11113.9 5516.4 4924.7 4860.9 6409.9 5913.8 7003.8 6518.1 6918.1 True False 6077.878793744845 9812.679421288061 4767.303179416201 4064.6935930681875 4421.2324532616 6345.422225723542 5467.717304772306 6818.036472451355 11060.739636811604 7806.105523000506 0.7786057690145898 1.2570518541384348 0.6107146726840234 0.5207069749559065 0.566381333205725 0.8128793810212923 0.7004411212046527 0.8734235595921899 1.4169344244990534 1.0 12.930387249934538 -8.079644877232925 5.458823090265815 1.2021606942826757 0.7522577453928188 0.41674886235165653 0.21397349436305754 0.2302268207737905 11.601580250216811 0.15723128280376952 0.058027857103304596 8.324441828109463e-09 8.079644877232925 -0.44990294888985694 RES(ph)PSPAPK ddPTM_A459_Selumetinib_30min_R2 3 RESPSPAPK 9 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RES(0.982)PS(0.018)PAPK;RES(0.994)PS(0.006)PAPK;RES(0.965)PS(0.035)PAPK 88.338 0.016083 76897000.0 108470.0 75177.0 72497.0 85538.0 83673.0 104367.0 208581.0 364225.0 174817.0 201899.0 True False 102441.67163981382 80942.83416784578 67832.62194876526 73887.57683871979 73161.24969388924 118742.60690070291 218280.42979541063 365284.83444930543 209785.284795096 196069.65127339956 0.5224759210540398 0.4128269400294851 0.3459618635939707 0.37684351636700236 0.3731390820493335 0.605614413702038 1.113280042973302 1.8630360796630998 1.0699528633453392 1.0 17.581006719065556 -7.268791742973096 2.8542129278601887 1.3675754151806065 0.40942125544519953 0.7641211425873804 0.2258854685420022 0.11470864705570888 1.8781718411684016 0.09718043231455062 0.06551943933964907 5.385279606668518e-08 7.268791742973096 -0.9581541597354071 RES(ph)PSPAPKPR ddPTM_A459_Selumetinib_30min_R1 1 RESPSPAPKPR 11 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RES(0.996)PS(0.004)PAPKPR 60.161 0.038205 288770000.0 4330.7 5779.7 5593.6 6344.4 6192.3 4691.8 5972.2 4633.4 2615.4 3973.1 True False 4431.5968839247025 5103.010037090369 4834.019843445449 5236.469639137776 5632.207558339357 4644.6047518135565 5521.712145754196 4510.507180595689 4438.142778741826 4483.086086271275 0.9885147861638771 1.1382806260886915 1.0782795044353155 1.168050208800053 1.2563237577763853 1.036028455049504 1.2316765815993462 1.006116566534019 0.9899749175758457 1.0 12.130276487607283 -7.8808258711069445 9.441638960049197 0.9961788275674303 1.12946517882846 0.37250795503852074 0.07706430241866934 0.29575642277790815 22.91863912577589 0.04133344806955295 0.019823655445081557 1.3157522728389722e-08 7.8808258711069445 0.13328635126102972 RES(ph)PSPAPKPR ddPTM_A459_Selumetinib_30min_R2 2 RESPSPAPKPR 11 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RES(0.986)PS(0.014)PAPKPR;RES(0.994)PS(0.006)PAPKPR 85.163 0.035315 592540000.0 27618.6 26952.4 32799.2 32452.8 38583.3 29045.7 25692.6 22988.9 22075.6 29890.0 True False 26083.668778015675 29019.562414374686 30688.93518106884 28032.672655797403 33736.12091492159 33046.481524387455 26887.356808921057 23055.793892982736 26491.336843800156 29026.998036453442 0.8986002874034236 0.9997438377172376 1.0572548750142285 0.9657448083536809 1.1622325144527248 1.1384739642344743 0.9262878915399614 0.7942879199574205 0.9126447320019492 1.0 14.82510775613459 -7.50414471292317 22.62785258448498 0.884137378008468 1.0381620778223326 0.3452157322350824 0.0862136530144347 224.8111424604059 271540.25729927607 0.03802466894615983 0.025061913964994315 3.1322418441386224e-08 7.50414471292317 0.15402469981386457 RES(ph)VASGDDR ddPTM_A459_Selumetinib_30min_R2 1 RESVASGDDR 10 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 RES(0.809)VAS(0.191)GDDR 98.407 0.035187 6431100.0 21070.0 13451.0 17569.0 20203.0 17290.0 19617.0 42876.0 62870.0 34525.0 27448.0 True False 19899.013749892856 14482.648448218104 16438.629667680867 17451.316547881084 15117.875625438826 22319.063684604203 44869.818957182244 63052.94129131122 41430.96470909966 26655.504921531414 0.7465254853911661 0.5433267346033093 0.6167067446695522 0.6546984046730439 0.567157728579627 0.8373153594466567 1.68332279164361 2.365475404683825 1.5543117577800272 1.0 14.702145890126788 -7.220885795807865 3.625676589814998 1.7780676677379506 0.6303084483880841 0.6929552562832548 0.32115429250958616 0.11663336645591905 3.2228236372426533 0.12820193342838676 0.09266044862325284 6.013318458447851e-08 7.220885795807865 -1.1477592193498665 RES(ph)VASGDDRAEEDMDEAIEK ddPTM_A459_Selumetinib_30min_R1 1 RESVASGDDRAEEDMDEAIEK 21 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 RES(0.5)VAS(0.5)GDDRAEEDMDEAIEK 77.554 0.0010111 6533500.0 1790.8 1809.6 1574.3 1355.3 1881.8 1361.0 2176.3 1647.6 1388.3 2153.1 True False 1832.5221557097843 1597.7311907397834 1360.5187070109 1118.622297131869 1711.591522258773 1347.3095756891273 2012.139938850817 1603.9002958409505 2355.8437025798257 2429.471357970018 0.7542884379756494 0.6576456172238195 0.5600060698586307 0.4604385614434866 0.7045119164067526 0.5545690305297085 0.8282213051205064 0.6601848960183314 0.9696939603141842 1.0 11.246426708696543 -8.135787933344734 0.9946184965517256 1.0127082446859303 0.6138009469889965 0.6372958962078186 0.10103142813730034 0.32526503421527514 0.6299118449657496 0.09371912003911737 0.0334340536348111 7.3149618698857965e-09 8.135787933344734 -0.3989072976969339 RES(ph)WISDIR ddPTM_A459_Selumetinib_30min_R2 1 RESWISDIR 9 1 I3L359;I3L2Y6;I3L1M1;I3NI06;I3L1G9;I3L167;A0A0A6YYL4;P57737-2;P57737-4;P57737;P57737-3 I3L359 CORO7;CORO7-PAM16 Coronin;Coronin-7 1 RES(1)WISDIR 98.182 0.01023 1877100.0 10991.0 11090.0 13705.0 11931.0 13724.0 11851.0 11331.0 10970.0 8773.1 11936.0 True False 10380.164220459052 11940.567340029656 12823.235220875764 10305.977217877004 11999.868425883322 13483.36767733315 11857.913951950546 11001.920883818735 10527.965140895074 11591.376666547605 0.8955074551598277 1.0301250389429417 1.1062737058561187 0.889107266060965 1.0352410046784704 1.1632240125752948 1.022994446049895 0.9491470426951077 0.9082583927479894 1.0 13.50076429982437 -7.7630111254434535 7.298352923922629 0.9461427828938084 1.0251581859709802 0.12569953455421612 0.08088655990125931 0.2501668938106934 79.98938810048425 0.04283233449477478 0.022328947060209152 1.7257936812835416e-08 7.7630111254434535 0.07901540307717181 RESAAS(ph)GLGGLLEEEGAGAGAAQEEVLEPGR ddPTM_A459_Selumetinib_30min_R2 1 RESAASGLGGLLEEEGAGAGAAQEEVLEPGR 31 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RES(0.175)AAS(0.825)GLGGLLEEEGAGAGAAQEEVLEPGR 85.93700000000003 6.5133e-07 4540000.0 1074.5 1238.0 932.26 2234.6 1543.1 2501.5 3266.9 1178.1 2679.5 3527.3 True False 1014.7835915643035 1332.9506192025879 872.2794065679412 1930.2436250999879 1349.2419825109698 2846.058918643903 3418.817323239543 1181.5280759550465 3215.474871485376 3425.4576839739784 0.2962475923471406 0.38913066287136 0.25464609025792523 0.5634994804141481 0.3938866297556106 0.8308550801719736 0.9980614675914689 0.3449256084764473 0.9386993412672975 1.0 11.742081047709128 -6.757151781470109 24.32093887368623 0.7925382608219574 0.38330587523247306 0.5710061723374227 0.19110641293908462 62.12627882683444 352404.27535004425 0.06335482916961169 0.061199396768695215 1.7492352419954832e-07 6.757151781470109 -0.4092323855894844 RESESESDET(ph)PPAAPQLIK ddPTM_A459_Selumetinib_30min_R2 1 RESESESDETPPAAPQLIK 19 1 O60832 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 RES(0.224)ES(0.03)ES(0.06)DET(0.686)PPAAPQLIK 112.32 0.00072027 4113000.0 16292.0 14014.0 20235.0 22782.0 19310.0 16708.0 20243.0 19602.0 23613.0 20216.0 True False 15386.555862043393 15088.82873788779 18933.102130202187 19679.052298857932 16884.105166409707 19009.375339877006 21184.339610743536 19659.038574714203 28336.259802345285 19632.311552524014 0.7837363328754444 0.7685711739811865 0.964384763330025 1.0023808070796385 0.8600161586290135 0.9682698488672404 1.079054779365499 1.0013613792812264 1.4433481114302231 1.0 14.260942428513909 -7.342641759206753 1.014813392753676 1.1870316764148785 0.8688021002313746 0.4721398725088706 0.13064669223277486 0.48604772490056414 0.9560924730392303 0.09759300073153132 0.05205070366505368 4.543162184497052e-08 7.342641759206753 -0.3182295761835039 RESGEEFR ddPTM_A459_Selumetinib_30min_R2 2 RESGEEFR 8 1 D6REW6;A0A3B3IRQ7;P30533 D6REW6 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 0 ; 138.06 0.0033713000000000003 3485500.0 15522.2 13966.1 13664.7 17269.0 15263.2 13088.9 12284.2 12931.9 12771.6 13942.9 False True 14659.538264289828 15037.254961910556 12785.52807900043 14916.932409313384 13345.700361260735 14891.777165795787 12855.439640680512 12969.529688008704 15326.276868319688 13540.332248995197 1.0826572047652439 1.110552879012732 0.9442551219486672 1.10166664561871 0.9856257672149141 1.0998088445651604 0.9494183306790341 0.9578442721722098 1.1318981385746294 1.0 13.72497551935577 -5.218266065141478 24.99968164475893 1.021639789198521 1.0966050955781543 0.17723524474672325 0.06488465036340525 786.6231631320001 455495.0139387547 0.01568249710866767 0.041491500001002886 6.049701337324965e-06 5.218266065141478 0.07496530637963339 RESIS(ph)PQPADSACSSPAPSTGK ddPTM_A459_Selumetinib_30min_R2 2 RESISPQPADSACSSPAPSTGK 22 1 Q9GZR1-2;Q9GZR1;H0Y4F4;F8W6D9 Q9GZR1-2 SENP6 Sentrin-specific protease 6 1 RES(0.167)IS(0.828)PQPADS(0.004)ACSSPAPSTGK;RES(0.375)IS(0.625)PQPADSACSSPAPSTGK 147.64 1.9059e-07 8248700.0 38594.0 35144.0 40855.0 40942.0 41365.0 35036.0 37817.0 41010.0 35453.0 40812.0 True False 36449.099984023 37839.431794229225 38226.43377956066 35365.62897111061 36168.35889220805 39861.890974858194 39575.56543296387 41129.332310429025 42544.59063958613 39633.651517689425 0.9196503120020348 0.9547298910205284 0.9644943707116996 0.8923131636086092 0.9125669098661088 1.0057587289696712 0.998534425103384 1.0377376480709086 1.0734461501887478 1.0 15.27443827099813 -6.887432126510298 3.848007468003555 1.0276753208725145 0.9302417871911224 0.7474134910499071 0.027556751799762063 0.12667649426426972 3.522284190613636 0.01093808724284928 0.009580543150604847 1.2958892090703317e-07 6.887432126510298 -0.09743353368139207 RESVAS(ph)GDDRAEEDMDEAIEK ddPTM_A459_Selumetinib_30min_R1 1 RESVASGDDRAEEDMDEAIEK 21 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 RES(0.128)VAS(0.872)GDDRAEEDMDEAIEK 70.027 0.0073423 13540000.0 3216.0 3172.3 1758.6 1627.5 2735.3 2301.1 3125.6 3401.2 1720.6 3613.7 True False 3290.92654275333 2800.885641237742 1519.7917792983349 1343.287676958694 2487.892597956438 2277.9530232316324 2889.8334755650044 3310.9891273453773 2919.732532348086 4077.5535954188185 0.807083577380988 0.6869034522034417 0.37272147225871893 0.3294347077296284 0.6101434450185071 0.5586567950427287 0.7087174718713122 0.8120038277523351 0.7160500687540787 1.0 11.993488124526722 -8.086770579506988 0.7664186860384176 0.9660661056356121 0.5436755148734465 0.47143185173963964 0.14006088921093401 0.5848181401831005 0.7107738071770466 0.1453708860352077 0.06030936319454331 8.18897264733418e-09 8.086770579506988 -0.4223905907621657 REVLYDS(ph)EGLS(ph)GEER ddPTM_A459_Selumetinib_30min_R2 1 REVLYDSEGLSGEER 15 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 2 REVLY(0.002)DS(0.998)EGLS(1)GEER 100.27 0.025887 7466100.0 36337.0 35977.0 37677.0 38794.0 40921.0 27854.0 33891.0 35442.0 31150.0 39192.0 True False 34317.53500853614 38736.320215712076 35252.90283961592 33510.19027661729 35780.13814161844 31690.635666562972 35466.99865374249 35545.13035226106 37380.870403720604 38060.42512695493 0.901659266654696 1.0177584744916175 0.9262351306383416 0.8804470828909609 0.9400877163686341 0.8326400864114158 0.9318602862537199 0.9339131193016418 0.9821453722346087 1.0 15.216004055851984 -8.269379810884178 2.2289805466571915 0.9996743951717854 0.9191251296713296 0.29782138208162257 0.044320545476855926 0.4107646344542684 3.7433401593440276 0.042961935194492595 0.012409680188760203 5.377992461404048e-09 8.269379810884178 -0.08054926550045571 REVMY(ph)T(ph)AFK ddPTM_A459_Selumetinib_30min_R2 1 REVMYTAFK 9 1 M0QXH4;H3BRH5;G3V1S7;M0R2V0;O00219-2;O00219;Q92839 M0QXH4 HAS1;HAS3 Hyaluronan synthase 3;Hyaluronan synthase 1 2 REVMY(1)T(1)AFK 52.786 0.043994 15856000.0 108000.0 108590.0 125740.0 115580.0 103820.0 86776.0 86442.0 88510.0 74531.0 110360.0 True False 101997.79235825474 116918.5038281173 117650.02529536054 99837.80461337914 90777.20343742405 98728.60632590178 90461.72428157339 88767.54944638062 89439.28257013485 107173.6200502845 0.9517061410298417 1.0909261418365883 1.0977517157688677 0.9315520420653562 0.8470107046382546 0.9212024962820102 0.844067077692532 0.8282593179621255 0.8345270275294524 1.0 16.70959031580977 -5.932148248854985 4.540009238782315 0.8720263044281262 1.0500248353443145 0.5978712433517868 0.06115580420058491 0.12986736425739667 5.245910778907563 0.017222510443611894 0.025934370849196184 1.1691002439788223e-06 5.932148248854985 0.17799853091618822 REVS(ph)PAPAVAGQSK ddPTM_A459_Selumetinib_30min_R1 5 REVSPAPAVAGQSK 14 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK 165.24 0.00045701 79058700.0 17687.0 21151.899999999998 22152.1 21257.4 20952.100000000002 17590.3 20219.5 18641.2 11047.300000000001 16944.600000000002 True False 18099.072687088978 18675.425714748457 19143.966492775293 17545.19414081826 19056.98625439369 17413.357552714526 18694.326836187156 18146.774820848706 18746.46123713182 19119.60446438103 0.9466238028515047 0.9767684132556163 1.0012741910241736 0.9176546603515869 0.9967249212658141 0.9107592986640928 0.9777569860827326 0.9491187359369979 0.9804837371011331 1.0 14.22276505751359 -8.518056985625362 4.457616789752739 0.9999526625847522 0.9604546189086977 0.17082100879057283 0.028588361563372005 0.28439644363947447 18.248881302034473 0.02580294752801344 0.006735400674836349 3.0334931205498653e-09 8.518056985625362 -0.039498043676054584 REVS(ph)PAPAVAGQSK ddPTM_A459_Selumetinib_30min_R2 5 REVSPAPAVAGQSK 14 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK;REVS(1)PAPAVAGQSK 139.2 0.00029395 188459400.0 499634.0 442243.0 482589.0 496052.0 555384.0 393253.0 497262.0 489591.0 367714.0 468124.0 True False 471866.342473373 476161.6160646293 451539.74914317444 428488.86186257127 485611.6967240442 447420.0311546952 520385.6683059597 491015.62875384715 441267.07478759927 454608.04378777987 1.037963029738316 1.047411330642691 0.9932506811383264 0.9425457110094568 1.0681986457563375 0.9841885493859845 1.144690850540441 1.0800856594237103 0.970653909048718 1.0 18.794263685715478 RFDAMPFTLR ddPTM_A459_Selumetinib_30min_R1 2 RFDAMPFTLR 10 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 ; 144.7 0.0026058 6162100.0 4401.1 4274.2 5698.4 4919.8 4667.1 4055.8 4088.9 4284.1 2405.1 3357.3 False True 4503.637066950149 3773.774676978327 4924.588579070645 4060.6492860837993 4244.961629043431 4015.0023343717608 3780.4709810077225 4170.471751281995 4081.279038446112 3788.242157871321 1.1888461400473989 0.9961809514043517 1.2999666794896387 1.0719085836808142 1.1205623748796323 1.0598589443468578 0.9979486060975665 1.100898933458218 1.0773543158971266 1.0 11.887312840598709 -6.560199608567039 1.8585147643514275 1.0498074455616209 1.1415594558549762 0.2439154935899761 0.0785770891665204 0.5462812690038702 3.831114307339882 0.029165321767811694 0.030870167210072828 2.752963107420867e-07 6.560199608567039 0.09175201029335533 RFDAQTGADR ddPTM_A459_Selumetinib_30min_R1 1 RFDAQTGADR 10 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 160.91 0.00058745 7130900.0 2523.1 2161.0 3006.8 2785.3 3134.7 2379.5 2283.0 2337.0 1375.6 1760.4 False True 2581.883320902031 1907.9891153783567 2598.493075170156 2298.8996415564056 2851.166938476235 2355.5643904131366 2110.791471946155 2275.015168354152 2334.2927301511263 1986.3644877480938 1.2998034030647951 0.9605433077095584 1.308165289501335 1.1573402845933012 1.4353694682231015 1.185867148220918 1.062640560161807 1.1453160698283005 1.1751583078277203 1.0 10.955914658998053 -8.730736180389437 0.6055451585334994 1.0019952806454433 1.2113632908633223 0.19917124959219246 0.12387506394944181 1.9573631424530848 1.5393401027652558 0.1384678139675433 0.05480752374003208 1.85893335303055e-09 8.730736180389437 0.20936801021787899 RFDAQTGADR ddPTM_A459_Selumetinib_30min_R2 3 RFDAQTGADR 10 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 ;; 149.94 0.0009863 23949800.0 35829.6 41576.2 41251.9 50157.5 51395.0 29274.0 33949.4 36295.9 31526.0 45751.6 False True 33838.33426925302 44764.96085144641 38597.79766567274 43325.9619734864 44938.30062287037 33306.227777086366 35528.11436945989 36401.51505989027 37832.08091003841 44430.63243106735 0.7615992034718856 1.0075247279204895 0.8687204199840266 0.9751371880808852 1.0114260852035055 0.7496230855763728 0.7996310749026716 0.8192886994432503 0.8514864371722285 1.0 15.439267056541546 -6.762128128909768 24.999999908850857 0.8299379883023923 0.9291447267910092 0.15442986771369083 0.09144364971683232 28.61795744989907 1038733.3837504577 0.029958255160435425 0.027997812835870186 1.7293060907181287e-07 6.762128128909768 0.09920673848861694 RFDDAVVQSDMK ddPTM_A459_Selumetinib_30min_R1 10 RFDDAVVQSDMK 12 1 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ;;;;;;;;; 214.42 2.2701e-06 482664700.0 65497.5 71143.9 77886.20000000001 81584.6 74483.99999999999 65440.799999999996 68207.59999999999 66579.90000000001 38744.200000000004 54971.700000000004 False True 67023.4643140504 62814.33911409822 67309.68183827247 67337.38114261394 67746.93535121821 64782.52496749232 63062.645817746125 64813.98477000534 65746.07763559274 62027.85316470226 1.0805381920293666 1.0126795610241033 1.0851525307436547 1.08559909310118 1.0922018398948954 1.0444102393077443 1.0166827094643462 1.0449174276257003 1.0599444327214984 1.0 15.92062857245467 -6.960530503450151 9.356659520491968 1.0336151288615636 1.0694786762166153 0.36007672705717464 0.025706285461024526 0.43810607433314447 98.42618529939935 0.009369398335146094 0.008245625042672894 1.0951396335733685e-07 6.960530503450151 0.035863547355051706 RFDDAVVQSDMK ddPTM_A459_Selumetinib_30min_R2 7 RFDDAVVQSDMK 12 1 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ;;;;;; 206.46 1.3947e-05 171461600.0 751991.0 705321.0 787394.0 802390.0 809947.0 612112.0 607423.0 618588.0 505228.0 685475.0 False True 710198.3506784845 759416.8527355315 736733.9272897652 693103.097800045 708194.2168419494 696424.8718005023 635669.3730858411 620387.988667244 606287.7172497916 665683.5556720607 1.066870804644532 1.1408075898297345 1.1067329529358338 1.0411900547855686 1.0638601641991454 1.0461800744009753 0.9549122367069471 0.9319563077398131 0.9107746647544804 1.0 19.344477004352207 -7.0709986894971655 1.336161519620203 0.9362421845872393 1.093327127493294 0.7848274942121021 0.03322072959511733 0.19039746382008504 0.6841559740016896 0.018970001819569916 0.013001061167230649 8.491830374798745e-08 7.0709986894971655 0.1570849429060548 RFDEILEASDGIMVAR ddPTM_A459_Selumetinib_30min_R1 2 RFDEILEASDGIMVAR 16 1 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 268.13 3.2025999999999996e-50 63388000.0 5135.0 6228.3 7508.2 6701.0 6938.0 5579.700000000001 5876.0 5329.700000000001 3266.8 4522.200000000001 False True 5254.635509029336 5499.087740541882 6488.6276795904505 5530.79614334882 6310.459125003385 5523.573283962253 5432.768589205261 5188.339042694534 5543.521002368198 5102.668419958207 1.0297818859788608 1.0776886303317592 1.2716146034908526 1.0839027128856864 1.236697861911057 1.082487206567793 1.0646916754292568 1.0167893767898462 1.0863964784945996 1.0 12.317036180661589 -6.990389645669069 24.677276541770905 1.0476857589287605 1.1425724150547425 0.2953675411444927 0.07134526480697584 233.1106235729215 598573.5017154965 0.025253076099446447 0.02224338776412517 1.0223753134068466e-07 6.990389645669069 0.09488665612598202 RFDEILEASDGIMVAR ddPTM_A459_Selumetinib_30min_R2 3 RFDEILEASDGIMVAR 16 1 P14618;P14618-3;B4DNK4;P14618-2;H3BTN5;H3BR70 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ;; 151.73 0.00026055 16084810.0 67572.6 57647.1 61482.8 70072.90000000001 76527.59999999999 53850.899999999994 49497.1 51045.4 46253.24 62958.0 False True 63817.18540655003 62068.44720535825 57527.063585411175 60528.85013750511 66913.5187225756 61268.37266520126 51798.813226642946 51193.933662979136 55505.180423505175 61140.23895547119 1.0437837093346736 1.0151816261392612 0.9409034797411977 0.9900002219747398 1.094426843364304 1.0020957345263795 0.8472131302000363 0.8373198165002919 0.907833881119273 1.0 15.899834570295752 -7.210528500757388 7.431690856698961 0.8846444597639214 1.0139914387425768 0.507061105543656 0.05556963311021252 0.20992387775644988 27.16392569373986 0.021645295292668856 0.016659432942292617 6.158451126955608e-08 7.210528500757388 0.12934697897865544 RFDYDWER ddPTM_A459_Selumetinib_30min_R1 1 RFDYDWER 8 1 Q93008;Q93008-3;O00507-2;O00507 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 0 101.65 0.022817 4263800.0 611.71 535.86 593.12 737.33 555.44 674.11 471.22 644.59 248.76 345.51 False True 625.9616528195402 473.12126208544436 512.577561774951 608.5691568982813 505.200550070897 667.3290654429078 435.67549601860134 627.493379276595 422.12755128845185 389.85957405239964 1.6056080047309724 1.2135684066126173 1.314774846868471 1.560995797980546 1.2958526189817126 1.7117164996266436 1.1175190376626323 1.6095369231390373 1.0827682052300072 1.0 8.606810754005407 -8.405603838485561 5.711814410304422 1.0039533198321091 1.4159907441837774 0.41695984443611445 0.18369933578513672 0.2006965576740483 7.999774405285894 0.1629499119298956 0.042303896581253525 3.93003267790845e-09 8.405603838485561 0.41203742435166824 RFEELGVK ddPTM_A459_Selumetinib_30min_R2 1 RFEELGVK 8 1 Q04760-2;Q04760 Q04760-2 GLO1 Lactoylglutathione lyase 0 101.46 0.023021 4629300.0 30614.0 30235.0 28165.0 34889.0 28732.0 23266.0 27199.0 24778.0 25216.0 25820.0 False True 28912.596437551947 32553.927279152078 26352.89456373335 30137.058013117996 25122.429292660992 26470.680312280245 28463.807393796043 24850.099877781275 30259.904593907508 25074.50951158338 1.153067278312883 1.2982876998696034 1.0509834520016996 1.2019002006478303 1.001911095451557 1.0556808818155303 1.1351690600626485 0.9910502881941345 1.2067994622159486 1.0 14.613933859763685 -5.507669685282952 1.504462213771576 1.0745465262115326 1.2227845618759203 0.2631795586522798 0.0858894863351975 0.5679300649954518 2.3983609880687813 0.024972032213935045 0.08235372191209374 3.1069217452425583e-06 5.507669685282952 0.14823803566438776 RFIGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 RFIGSPR 7 1 P23443-3;P23443-5;P23443-2;P23443;K7ERJ3;P23443-4 P23443-3 RPS6KB1 Ribosomal protein S6 kinase beta-1 1 RFIGS(1)PR;RFIGS(1)PR 96.034 0.012016 5779100.0 2073.38 2286.39 2290.4700000000003 2900.6 2833.0 1751.78 2124.39 1790.2199999999998 1053.68 2139.14 True False 2121.685719904821 2018.698395886127 1979.436754651119 2394.0646610054605 2576.7556502067728 1734.158683688979 1964.1455519437998 1742.7375501459005 1788.0180022576606 2413.7194559881036 0.8790109035419226 0.8363434246171467 0.8200773912396532 0.9918570507712144 1.0675456270670558 0.7184590899272786 0.8137422711123394 0.7220133001879775 0.7407729170106474 1.0 11.237042287608784 -6.791184013889252 24.999924763398877 0.7825449009568538 0.9129324968742218 0.24961773307255408 0.1017590317326311 284.6078766966028 239206.69782500376 0.036498245913135136 0.03219276532158565 1.6173945899967e-07 6.791184013889252 0.13038759591736804 RFIGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 RFIGSPR 7 1 P23443-3;P23443-5;P23443-2;P23443;K7ERJ3;P23443-4 P23443-3 RPS6KB1 Ribosomal protein S6 kinase beta-1 1 RFIGS(1)PR;RFIGS(1)PR;RFIGS(1)PR 83.99799999999998 0.019636 28868800.0 42635.0 41499.0 45078.0 47549.0 47591.0 38360.0 37119.0 34812.7 27467.9 42657.0 True False 40265.51738142769 44681.83985968354 42177.73055721544 41072.74417339987 41612.193111061875 43643.74180259046 38845.10704990314 34913.99919344726 32962.24751725064 41425.38157380375 0.9720011222996308 1.0786102182324635 1.0181615462508484 0.9914874073090765 1.0045095912254978 1.0535507494320713 0.9377127155895094 0.8428165985929238 0.7957017235562421 1.0 15.338227365882092 -7.508186220308993 3.859954534407798 0.86602814479376 1.0198126078446934 0.5569956955556938 0.056181138616869984 0.14592648477332923 4.841260512566349 0.02579017880183513 0.015358606807922856 3.103228675258141e-08 7.508186220308993 0.1537844630509334 RFPEAEALS(ph)PEQAAHYLR ddPTM_A459_Selumetinib_30min_R1 5 RFPEAEALSPEQAAHYLR 18 1 Q2NKX8 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 RFPEAEALS(1)PEQAAHYLR;RFPEAEALS(1)PEQAAHYLR;RFPEAEALS(1)PEQAAHYLR;RFPEAEALS(1)PEQAAHYLR;RFPEAEALS(0.998)PEQAAHY(0.002)LR 130.83 0.00038656 52802500.0 10184.15 11378.61 14231.600000000002 15339.099999999999 12952.300000000001 12475.400000000001 12363.779999999999 11225.199999999999 5762.3 9011.9 True False 10421.420880093701 10046.397051427723 12299.026888583068 12660.414135568113 11780.76675191429 12349.908802756912 11431.170120463614 10927.471231411657 9778.202238259539 10168.665148339604 1.0248563334584155 0.9879759933945857 1.2095025953914238 1.2450418959498708 1.158536207069216 1.214506390228955 1.1241564112601503 1.074621995316264 0.961601360219456 1.0 13.311842687037378 -8.01368090948894 2.612180565441074 0.9814900022479722 1.1429100346608259 0.39369569218306866 0.0771394954003821 0.3301529326869803 4.26083202526858 0.068058313849897 0.023631597689776924 9.689895434258063e-09 8.01368090948894 0.16142003241285363 RFPEAEALS(ph)PEQAAHYLR ddPTM_A459_Selumetinib_30min_R2 2 RFPEAEALSPEQAAHYLR 18 1 Q2NKX8 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 RFPEAEALS(1)PEQAAHYLR;RFPEAEALS(1)PEQAAHYLR 98.957 0.0016152 20398600.0 44135.0 35468.0 39963.0 55714.0 49842.0 31750.0 32699.0 32640.0 30209.0 46711.0 True False 41682.15338640348 38188.281552405 37391.8240884245 48125.65708798927 43580.40236686652 36123.27430219622 34219.5682918393 32734.976996157133 36251.64410998383 45362.33206024675 0.9188714841874632 0.8418500508678934 0.8242923674815388 1.0609167320602584 0.960717855267811 0.7963275400881082 0.7543608703007488 0.7216334678887554 0.7991574168152816 1.0 15.469207190139754 -6.774889830468454 23.874597914896878 0.7931519405846537 0.9192780253740854 0.23425065477957674 0.09286992519617308 176.59326324314 313450.600426197 0.03317682523351986 0.029443463631473262 1.679229942284351e-07 6.774889830468454 0.12612608478943177 RFPTDYAST(ph)SEDEFGSNR ddPTM_A459_Selumetinib_30min_R1 1 RFPTDYASTSEDEFGSNR 18 1 H0Y2V6;Q5SW79-3;Q5SW79 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 RFPTDYAS(0.003)T(0.498)S(0.498)EDEFGSNR 102.16 0.0029552 6992900.0 1031.5 1385.7 864.39 1372.1 1202.1 842.19 1025.6 986.37 495.81 779.93 True False 1055.5319430503919 1223.4615998055478 747.0105857544002 1132.4884925069268 1093.3702672479922 833.7183332473383 948.2381662847024 960.2082634186929 841.3533574703613 880.0416126615374 1.1994114003974352 1.3902315324674188 0.8488355266465101 1.2868578896876324 1.242407462916757 0.9473623988369115 1.0774924192697162 1.0910941591894785 0.9560381524753471 1.0 9.781427932798588 -6.7562300856633835 24.99787486815572 1.0240342442941777 1.1905086968847232 0.29877503235633673 0.13679189054760604 184.55119980306003 885606.7303510823 0.04578286076557007 0.04447897926538628 1.7529515563966275e-07 6.7562300856633835 0.1664744525905455 RFPTDYASTS(ph)EDEFGSNR ddPTM_A459_Selumetinib_30min_R1 1 RFPTDYASTSEDEFGSNR 18 1 H0Y2V6;Q5SW79-3;Q5SW79 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 RFPTDYAS(0.005)T(0.131)S(0.864)EDEFGSNR 89.51100000000002 0.0031299 5275200.0 658.72 988.73 936.91 1021.8 1167.6 1216.4 880.88 709.03 533.81 669.12 True False 674.0668943540035 872.9690319518935 809.682768078246 843.3618115615312 1061.9907861565225 1204.1641204028333 814.4345123994432 690.2242211459751 905.8365820601716 755.0080697807347 0.8927942909931575 1.1562380150524967 1.0724160449217313 1.117023572749965 1.4065952784649574 1.5949023177362065 1.078709678740211 0.9141944950951667 1.1997707287065684 1.0 9.560348254305724 -3.8918328108624465 15.369569427694842 1.1566114630601552 1.1105381356555843 0.0 0.20592985150731555 57670657.603281036 0.0 0.05204566835298694 0.0 0.00012828243329229496 3.8918328108624465 -0.04607332740457082 RFPTDYASTS(ph)EDEFGSNR ddPTM_A459_Selumetinib_30min_R2 2 RFPTDYASTSEDEFGSNR 18 1 H0Y2V6;Q5SW79-3;Q5SW79 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 RFPTDYAST(0.253)S(0.746)EDEFGSNR;RFPTDYAST(0.051)S(0.945)EDEFGS(0.005)NR 128.75 0.00034097 6391500.0 20856.1 20954.0 25140.4 26381.8 31040.0 18276.1 19196.3 16873.800000000003 15030.5 22911.8 True False 19697.001455583308 22561.10442227063 23522.89403479788 22788.553328856557 27140.47769887921 20793.466881082473 20088.965986746814 16922.89996439204 18037.01998725917 22250.276801994438 0.885247479429907 1.01396960689713 1.0571955685822914 1.024191902494169 1.2197815757710677 0.9345262113421716 0.902863643698406 0.7605703117758575 0.8106424988673576 1.0 14.441535663420876 -7.13982393734571 3.108019119314996 0.8460597981064232 1.0402625304410953 0.3919077848580623 0.09775253921181434 0.2469622795515547 4.527471817554997 0.04104734860232644 0.030627380642995406 7.247297054029957e-08 7.13982393734571 0.1942027323346721 RFQDAVR ddPTM_A459_Selumetinib_30min_R1 2 RFQDAVR 7 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 ; 143.61 0.0042777 18209400.0 4874.799999999999 5176.4 5408.5 6008.8 5947.5 5141.5 5176.5 4819.700000000001 3173.0 4001.3 False True 4988.373355290403 4570.344681556926 4674.055406763929 4959.475879145561 5409.54967511641 5089.781178108487 4786.0324373759395 4691.865899408008 5384.34925324914 4514.905830962535 1.104867641110231 1.0122790712962826 1.0352498106848587 1.0984671806738984 1.1981533785308531 1.1273283139602923 1.0600514421705232 1.0391946310888496 1.1925717733300425 1.0 12.140480181865417 -5.8211482331947275 6.352526130752574 1.107577096996069 1.0470492245281884 0.12062802334743983 0.06249875373332972 0.37332586005338975 29.58910659433258 0.017730307793316153 0.0267846517118369 1.509564822245252e-06 5.8211482331947275 -0.060527872467880606 RFQDAVR ddPTM_A459_Selumetinib_30min_R2 2 RFQDAVR 7 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 ; 152.47 0.0027849 5138700.0 25906.0 25938.0 31496.0 28991.0 30117.0 20373.2 21828.2 21224.3 19291.6 23386.0 False True 24466.248229934718 27927.361196184782 29469.581650251934 25042.375787735516 26333.43321060391 23179.423370504068 22843.25455175775 21286.059199127994 23150.459052340837 22710.785415874867 1.077296437878048 1.2296959653655801 1.2976029278869703 1.1026644534376546 1.1595122197842092 1.0206350395218662 1.0058328733884423 0.9372665369929924 1.0193596843268413 1.0 14.471089979737535 -6.726223726148419 1.544302421485778 0.9817394146897158 1.193339184465118 0.6745185706523393 0.06140060729498268 0.22006390544755614 1.090678347169182 0.026993909096005422 0.025217886340620183 1.8783489388966784e-07 6.726223726148419 0.21159976977540218 RFQTGMHREK ddPTM_A459_Selumetinib_30min_R1 1 RFQTGMHREK 10 2 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 0 75.387 0.031615 954820.0 552.14 597.8 233.86 330.24 1421.2 335.07 972.13 651.43 0.0 0.0 False True 565.0037877225819 527.8092980903199 202.10309650102852 272.56978337255833 1292.6527109332387 331.6995000192181 898.8014514336465 634.1519602571436 0.0 0.0 0.0 RFS(ph)DFLGLYEK ddPTM_A459_Selumetinib_30min_R1 2 RFSDFLGLYEK 11 1 Q13596-2;Q13596;Q13596-3 Q13596-2 SNX1 Sorting nexin-1 1 RFS(1)DFLGLYEK;RFS(1)DFLGLYEK 112.12 0.0040323 9516700.0 9748.7 9858.4 10450.8 11155.400000000001 10389.2 10429.5 10029.400000000001 9870.9 6012.9 7920.299999999999 True False 9975.825742331897 8704.173944954182 9031.638762135242 9207.318802792628 9449.498694362233 10324.588699228332 9272.874283283732 9609.091666798031 10203.452135159712 8936.947655255188 1.1162452916982029 0.9739537793796825 1.0105954639696668 1.0302531868784588 1.0573519124066537 1.1552701322086374 1.0375885191440066 1.0752095723809687 1.1417155530904093 1.0 13.125566458962304 -6.523335576427829 24.997455939892998 1.0863761915446322 1.0290810876067822 0.15396864799475762 0.05362304309652311 25.509163711872972 1395686.293220831 0.01697446039152477 0.01713681262794167 2.9968459813645473e-07 6.523335576427829 -0.05729510393784998 RFS(ph)DQAGPAIPTSNSYSK ddPTM_A459_Selumetinib_30min_R1 2 RFSDQAGPAIPTSNSYSK 18 1 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 RFS(1)DQAGPAIPTSNSYSK;RFS(1)DQAGPAIPTSNSYSK 108.97 0.0021631 16179500.0 3573.0 4081.3999999999996 3875.7 4348.9 3622.3 3662.6 3486.8999999999996 3578.42 2086.34 2940.7 True False 3656.2439481522533 3603.547790608617 3349.4012276962094 3589.446253963541 3294.663604569007 3625.757569374724 3223.8803256807028 3483.508677253687 3540.3665997553776 3318.1674898436845 1.101886495887673 1.0860053935307457 1.0094129479443474 1.0817555970125656 0.9929166067274727 1.092698780417962 0.9715845675507406 1.0498290661686254 1.0669644044768098 1.0 11.696170995147629 -5.123804648155551 5.315509135980264 1.0352746030498552 1.0981092040830922 0.291790818118315 0.03804933142534296 0.2564458239410368 9.818881484349186 0.009049414184499373 0.025567421549947764 7.519610607531457e-06 5.123804648155551 0.06283460103323701 RFS(ph)DQAGPAIPTSNSYSK ddPTM_A459_Selumetinib_30min_R2 3 RFSDQAGPAIPTSNSYSK 18 1 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 RFS(1)DQAGPAIPTSNSYSK;RFS(1)DQAGPAIPTSNSYSK;RFS(1)DQAGPAIPTSNSYSK 98.887 0.0016238 15874400.0 104912.0 87002.0 93938.0 117400.0 102046.0 83271.0 95674.0 98718.0 93273.0 123535.0 True False 99081.41103601133 93674.77364447794 87894.1313519611 101409.91747370403 89226.06917718505 94740.82439112397 100123.0305744345 99005.25303635543 111930.20626536878 119968.22356752318 0.825897125835527 0.7808298802703687 0.7326451016630298 0.8453064858181071 0.7437475235012116 0.7897159895661857 0.8345795878029404 0.825262307736274 0.9329987803176041 1.0 16.87229279883384 -8.330433696502006 1.1567000956469058 1.0021416314745566 0.7857074386973005 0.814127512808436 0.03360298188165176 0.1793492366494099 0.49924326893154225 0.030716215219583887 0.009959585396562295 4.672682833166139e-09 8.330433696502006 -0.21643419277725606 RFS(ph)DSEER ddPTM_A459_Selumetinib_30min_R1 1 RFSDSEER 8 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 RFS(0.772)DS(0.228)EER 109.72 0.022141 15466000.0 2894.8 3477.7 4046.5 4233.2 3910.6 3305.7 3720.2 3045.9 1871.5 2895.7 True False 2962.243207699732 3070.529267261132 3497.0075258334527 3493.9510870055556 3556.8869204725042 3272.447659335453 3439.5823188497975 2965.112837522426 3175.7988110481488 3267.3913015065637 0.9066080350810353 0.939749477157921 1.0702750920041366 1.0693396549701675 1.088601453652783 1.0015475213594889 1.0526998456731638 0.9074862983675204 0.9719677008333276 1.0 11.673923526379536 -10.411753680882935 12.799272809132393 1.0000001382316954 1.0045448406035231 0.0 0.06494915257939685 0.0 0.0 0.06842862047405904 0.016596378237049923 3.8747734842045913e-11 10.411753680882935 0.004544702371827691 RFS(ph)DSEGEETVPEPR ddPTM_A459_Selumetinib_30min_R1 1 RFSDSEGEETVPEPR 15 1 A0A1B0GWH8;H3BQ48;A0A1B0GWD3;A0A1B0GV71;A0A1B0GW34;A0A0D9SFH9;H3BPL0;Q9UBD8;A0A1B0GV41;H3BR84;O95090;H3BR00;Q9UP10;Q9UBH5;A0A0D9SF04;Q13286-5;Q13286-4;Q13286-6;Q13286-2;Q13286-7;Q13286-3;Q13286 A0A1B0GWH8 CLN3 Battenin 1 RFS(0.75)DS(0.249)EGEET(0.001)VPEPR 75.743 0.019558 3400500.0 2421.1 2172.0 2237.0 2624.9 2340.2 2080.5 2270.3 2481.2 1319.3 1568.6 True False 2477.506919359482 1917.7012302645946 1933.2276869614318 2166.5104904754994 2128.529323195868 2059.5720589428583 2099.0494431709835 2415.3905159265396 2238.755742140432 1769.9450894578852 1.3997648481390546 1.0834806354653441 1.0922529170402446 1.2240552000057119 1.2025962476880079 1.1636361326744225 1.1859404315271156 1.364669746148084 1.2648729926565907 1.0 10.789488887684692 RFS(ph)DSEGEETVPEPR ddPTM_A459_Selumetinib_30min_R2 3 RFSDSEGEETVPEPR 15 1 A0A1B0GWH8;H3BQ48;A0A1B0GWD3;A0A1B0GV71;A0A1B0GW34;A0A0D9SFH9;H3BPL0;Q9UBD8;A0A1B0GV41;H3BR84;O95090;H3BR00;Q9UP10;Q9UBH5;A0A0D9SF04;Q13286-5;Q13286-4;Q13286-6;Q13286-2;Q13286-7;Q13286-3;Q13286 A0A1B0GWH8 CLN3 Battenin 1 RFS(0.501)DS(0.498)EGEET(0.001)VPEPR;RFS(0.871)DS(0.129)EGEETVPEPR;RFS(0.857)DS(0.139)EGEET(0.004)VPEPR 101.53 0.003533099999999999 14082000.0 72998.0 55113.8 66460.0 72513.0 60102.0 44721.4 52674.0 48122.0 48089.0 53083.0 True False 68941.06339414703 59340.851241201664 62184.035956176784 62636.60430809783 52551.449441302786 50881.36690955083 55123.445371550915 48262.02705297401 57708.14371892525 51550.35586380251 1.337353782315126 1.1511239883189528 1.2062775302748394 1.2150566811524153 1.0194197219539123 0.9870226122973977 1.069312606050453 0.9362113266586101 1.1194518980895454 1.0 15.653694766428401 -6.257471281996128 6.8516723390261856 1.0190493288651998 1.2210140371900877 0.7192382596786953 0.06285542427295446 0.07293100826438462 21.849989041728676 0.017985529045030774 0.02197597229277924 5.527499576849063e-07 6.257471281996128 0.2019647083248879 RFS(ph)EGVLQSPSQDQEK ddPTM_A459_Selumetinib_30min_R1 2 RFSEGVLQSPSQDQEK 16 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RFS(1)EGVLQSPSQDQEK;RFS(1)EGVLQSPSQDQEK 150.59 0.0002542 24868500.0 4925.6 5633.0 5351.799999999999 5758.2 5605.700000000001 4893.700000000001 4807.799999999999 5111.8 3047.1000000000004 3503.5 True False 5040.356896450813 4973.485741289346 4625.054955333121 4752.638464800953 5098.66542476672 4844.47382112409 4445.143775218012 4976.218458533484 5170.706148621324 3953.2083519799194 1.275004109997493 1.2580884432257238 1.1699497075626473 1.2022231164265977 1.2897537824468857 1.2254537048870169 1.1244395385817982 1.2587797089018093 1.3079771386275745 1.0 11.948808278384467 -10.722143258944387 4.779628555197153 0.9999655711049733 1.231285169235885 0.6323912473932733 0.053612110972148797 2.043269906425254e-05 3.423034712707034e-06 0.053924433003514446 0.013076651460849121 1.896080365767235e-11 10.722143258944387 0.23131959813091174 RFS(ph)EGVLQSPSQDQEK ddPTM_A459_Selumetinib_30min_R2 4 RFSEGVLQSPSQDQEK 16 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RFS(1)EGVLQSPSQDQEK;RFS(1)EGVLQSPSQDQEK;RFS(1)EGVLQSPSQDQEK;RFS(1)EGVLQSPSQDQEK 178.07 5.804399999999999e-07 43906300.0 200397.0 148956.0 175893.0 212298.0 169822.0 121890.0 143748.0 139308.0 135002.0 126272.0 True False 189259.7369927518 160380.44623097026 164576.23587781808 183382.64616552248 148487.4421320575 138679.24109274644 150432.56683125815 139713.36321631895 162006.1722710464 122626.1992659435 1.5433874500366593 1.3078807562415586 1.3420968509420743 1.4954605725634085 1.2108949231153112 1.1309103757834666 1.2267571508516713 1.1393435012473798 1.3211383312932847 1.0 16.903907720292693 -6.368996440345435 5.714760134356954 1.1761766532428446 1.4075541545451413 0.6039762514188618 0.09939613345810001 0.16916700314369096 7.6005861996476805 0.029760677682448194 0.033797946426139924 4.2756639064561126e-07 6.368996440345435 0.23137750130229673 RFS(ph)FCCSPEPEAEAEAAAGPGPCER ddPTM_A459_Selumetinib_30min_R1 4 RFSFCCSPEPEAEAEAAAGPGPCER 25 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 RFS(0.937)FCCS(0.063)PEPEAEAEAAAGPGPCER;RFS(0.916)FCCS(0.084)PEPEAEAEAAAGPGPCER;RFS(0.848)FCCS(0.152)PEPEAEAEAAAGPGPCER;RFS(0.934)FCCS(0.066)PEPEAEAEAAAGPGPCER 192.77 3.2284e-27 465540000.0 3986.94 4428.17 4671.82 5325.07 4241.530000000001 4428.32 3927.24 4034.6 2237.4700000000003 2948.48 True False 4079.8279447652253 3909.7177977996193 4037.4125044703446 4395.146488443891 3857.8843604029435 4383.77512139286 3631.0051249609346 3927.5893017722155 3796.8231716569044 3326.946128627301 1.2262981686597263 1.1751671492837699 1.2135491073118705 1.3210753401220026 1.1595872644907261 1.3176573806446354 1.0913928222994969 1.1805388936047305 1.1412337395506535 1.0 11.699982790320355 -8.65312160612923 0.6069572466750898 0.9986964487123826 1.2303699177005372 0.5484407040708317 0.061677892877957344 0.7592409801801099 0.6248095151345917 0.06449661641378218 0.026401553694168255 2.222687432222846e-09 8.65312160612923 0.23167346898815455 RFS(ph)FCCSPEPEAEAEAAAGPGPCER ddPTM_A459_Selumetinib_30min_R2 3 RFSFCCSPEPEAEAEAAAGPGPCER 25 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 RFS(0.947)FCCS(0.053)PEPEAEAEAAAGPGPCER;RFS(0.5)FCCS(0.5)PEPEAEAEAAAGPGPCER;RFS(0.749)FCCS(0.251)PEPEAEAEAAAGPGPCER 139.04 1.4511e-08 179875000.0 87758.0 74570.0 93934.0 104853.0 108956.0 90070.0 84334.0 78048.0 84764.0 84346.0 True False 82880.76168310858 80289.27921965817 87890.38870760634 90571.84051848613 95267.97320100144 102476.32492594699 88255.69810465066 78275.10675845809 101719.16850404434 81910.71182277352 1.0118427717052918 0.9802048771517996 1.0730023796859534 1.1057386574109171 1.1630709962224284 1.2510735488133755 1.0774622285740294 0.9556150229510687 1.2418298686517275 1.0 16.32176451130662 -5.4703823714726605 2.731621290095714 1.117905356806477 0.9954690606636574 0.2152792874099848 0.08822574558682965 0.41886566443748824 6.112217122018255 0.02508948715338862 0.05913675412965021 3.3854595451767776e-06 5.4703823714726605 -0.12243629614281959 RFS(ph)FSQR ddPTM_A459_Selumetinib_30min_R1 4 RFSFSQR 7 1 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 RFS(0.988)FS(0.012)QR;RFS(0.992)FS(0.008)QR;RFS(0.986)FS(0.014)QR;RFS(0.997)FS(0.003)QR 86.882 0.01762 133426000.0 8711.6 10189.4 10294.5 11465.1 10446.300000000001 9421.1 10558.5 9586.6 4982.0 7994.200000000001 True False 8914.563330177212 8996.420311076457 8896.563443640805 9462.935511581636 9501.434009444061 9326.332287674393 9762.063844302886 9332.332226334578 8454.09012911668 9020.333440102138 0.9882742571960036 0.9973489750479324 0.9862787781312958 1.0490671519427208 1.0533351203186205 1.0339232301781507 1.0822287124002756 1.0345883872590975 0.9372259002679343 1.0 13.13896504890666 -3.6958848927849592 12.362067976310097 1.0200994971931914 0.9839402121443084 0.0 0.04018841951195482 0.0 0.0 0.009615949527397333 0.0 0.00020142580464462356 3.6958848927849592 -0.036159285048882994 RFS(ph)FSQR ddPTM_A459_Selumetinib_30min_R2 5 RFSFSQR 7 1 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 RFS(0.998)FS(0.002)QR;RFS(0.997)FS(0.003)QR;RFS(0.915)FS(0.085)QR;RFS(0.945)FS(0.055)QR;RFS(0.986)FS(0.014)QR 86.882 0.01762 192255400.0 94505.6 84213.7 93545.1 100430.6 94982.4 64707.5 91049.29999999999 76373.20000000001 79758.0 89114.5 True False 89253.3570878915 90672.62000027552 87526.51011020414 86751.77902755172 83049.86175857032 73620.37076879879 95283.27286076531 76595.43336773616 95711.82862471735 86541.53283772257 1.0313355236641577 1.0477353130582898 1.0113815556552312 1.0024294253052277 0.9596532327928646 0.8506940928218506 1.101012077512363 0.8850713738958527 1.1059641017012072 1.0 16.40110505378506 -5.7045064342385485 2.17866421269949 0.9780834143441023 1.0381127644863188 0.06930889673411877 0.07593440309543267 0.7593720074203 7.323743934455273 0.021622313292499053 0.04363966418088672 1.974665623767538e-06 5.7045064342385485 0.06002935014221655 RFS(ph)GTAVYENPQR ddPTM_A459_Selumetinib_30min_R2 1 RFSGTAVYENPQR 13 1 Q6AHZ1-2;Q6AHZ1 Q6AHZ1-2 ZNF518A Zinc finger protein 518A 1 RFS(0.915)GT(0.085)AVYENPQR 93.181 0.008962799999999998 3693500.0 7587.4 5409.2 8919.7 7951.1 6558.8 7250.4 6158.2 6736.7 4982.6 5627.6 True False 7165.722682768724 5824.068246680647 8345.816213035067 6868.146463587455 5734.824907584053 8249.076787421844 6444.568502241798 6756.302681679276 5979.259225476032 5465.11656573922 1.3111747199850396 1.065680516897241 1.5271067163242105 1.2567246061399349 1.0493508854935745 1.5094054606511509 1.179218855576248 1.2362595747791536 1.0940771625915482 1.0 12.416036552200705 -8.357536875174645 1.525463167604587 0.9997531741010396 1.2741410898450154 0.2730212991859947 0.1493362596552088 0.5081392956045444 2.4158699694467134 0.13736520392863058 0.04118583531339471 4.389985894663599e-09 8.357536875174645 0.2743879157439758 RFS(ph)ISFAR ddPTM_A459_Selumetinib_30min_R1 1 RFSISFAR 8 1 A0A087WZV0;O43314;K7ENU7 A0A087WZV0;K7ENU7 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 RFS(0.995)IS(0.005)FAR 75.566 0.029731 8369700.0 1119.1 1194.7 1081.2 1157.0 1316.3 1132.0 1242.6 1217.5 678.41 896.04 True False 1145.172852610464 1054.8239685990382 934.3789786064823 954.9516695798512 1197.2408974116397 1120.6131077737639 1148.869681577001 1185.2079450026451 1151.212220894028 1011.0554621687132 1.1326508737256302 1.0432899163973077 0.9241619412274773 0.9445096785605417 1.1841495765658185 1.1083596792702644 1.1363072794371503 1.1722481993820348 1.1386242040814245 1.0 9.981646424139493 -6.264340230944894 24.99624987072878 1.131799098922436 1.0072349344903517 0.37140761530066957 0.07087222635821837 262.8271220810478 2264742.646716751 0.022168353585688028 0.026225545878970812 5.440762506827934e-07 6.264340230944894 -0.12456416443208429 RFS(ph)LDER ddPTM_A459_Selumetinib_30min_R2 2 RFSLDER 7 1 Q7LBC6;Q7LBC6-2 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 RFS(1)LDER;RFS(1)LDER 66.92 0.039372 6491200.0 23864.0 25036.4 30329.8 27941.4 31082.4 21935.1 20843.0 24787.8 21023.6 29273.9 True False 22537.73441516104 26956.611375285684 28378.41368858938 24135.7331183965 27177.551031818402 24956.460917987548 21812.240799620977 24859.928394158793 25228.907448464244 28428.686444273484 0.7927814202509844 0.9482186744057488 0.9982316187635806 0.8489922024961609 0.9559903896753167 0.8778619077918965 0.7672616475748113 0.8744663051136659 0.8874454153173235 1.0 14.795059819960851 -6.981991082494249 23.9160897989699 0.8647935653753497 0.9130969057177455 0.010054937224819982 0.0757010311292448 389.3224019248584 517021.7293948398 0.026141045966080034 0.023048702908870372 1.0423388318459869e-07 6.981991082494249 0.048303340342395806 RFS(ph)LDTDYR ddPTM_A459_Selumetinib_30min_R2 2 RFSLDTDYR 9 1 E9PP00;Q9C0D7;Q9C0D7-2 E9PP00 ZC3H12C Probable ribonuclease ZC3H12C 1 RFS(0.999)LDT(0.001)DYR;RFS(1)LDTDYR 106.26 0.0068136 4305800.0 31196.0 26751.6 26835.0 36062.0 30158.0 21868.9 23620.9 22500.5 19935.3 27080.0 True False 29462.251207482535 28803.361700048423 25108.465315738842 31150.293389580158 26369.282424059234 24881.14246889132 24719.31865392541 22565.972729841702 23922.91703882156 26298.130037710216 1.120317344436092 1.095262730039962 0.9547623834749674 1.1845060217175967 1.0027056063015503 0.9461183146183015 0.9399648803348044 0.8580827875397686 0.9096812969027563 1.0 14.682672598031491 -6.628526121892141 3.003769918714443 0.9206254079402252 1.0810053394239094 0.5723700586775838 0.06354945268472084 0.185452850074733 3.362832592881091 0.022155358016642267 0.022167445582211752 2.3521980094117102e-07 6.628526121892141 0.16037993148368423 RFS(ph)PSQVPIQTR ddPTM_A459_Selumetinib_30min_R1 1 RFSPSQVPIQTR 12 1 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 RFS(0.989)PS(0.011)QVPIQTR 68.97800000000001 0.034732 15785000.0 1919.6 2598.9 2239.9 2565.7 2382.3 1872.9 2182.2 2044.9 1175.1 1569.6 True False 1964.322945108612 2294.6195798041686 1935.7338828899938 2117.6486591538674 2166.8213856292255 1854.0603264571407 2017.5948971006999 1990.662609228672 1994.0588740917315 1771.0734491987084 1.109114331761529 1.2956094965131624 1.0929721089578657 1.1956865256559297 1.2234508888434674 1.0468568242022815 1.1391932378713745 1.1239864784429539 1.1259041091683177 1.0 10.790408328822744 -6.756154128870825 24.999135565384094 1.0981876032455227 1.185264899516598 0.3411929799794339 0.0659169919858138 164.96102934038404 780263.7835749827 0.021018478928487367 0.020432615517988008 1.7532581691389125e-07 6.756154128870825 0.0870772962710753 RFS(ph)PSQVPIQTR ddPTM_A459_Selumetinib_30min_R2 1 RFSPSQVPIQTR 12 1 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 RFS(0.998)PS(0.002)QVPIQTR 111.66 0.016493 0.0 19940.0 21767.0 23682.0 20007.0 26139.0 21396.0 19931.0 15128.0 18590.0 22811.0 True False 18831.814626144434 23436.458908063603 22158.325903012024 17282.01208599994 22855.18513437512 24343.104786450087 20857.83099252726 15172.019975424782 22308.519447998915 22152.387159904294 0.8501031735410404 1.0579653894133574 1.000268085920712 0.7801422014364345 1.0317256090460032 1.0988930723687866 0.9415613243831268 0.6848932291543758 1.0070481021737114 1.0 14.435174552740033 -7.53675767504041 24.98628754840416 0.8702278756874711 0.973660370865862 0.05229961092566471 0.1222682627685092 507.5254907013803 913688.4698178531 0.056500407381304255 0.03263969289417941 2.9056434752810393e-08 7.53675767504041 0.10343249517839093 RFSEGTSADR ddPTM_A459_Selumetinib_30min_R1 2 RFSEGTSADR 10 1 P62333;A0A087X2I1;H0YJX2 P62333 PSMC6 26S protease regulatory subunit 10B 0 ; 136.49 0.0025032 2466400.0 1059.25 1518.4 1442.6100000000001 1335.83 1286.4299999999998 1249.49 1291.8 988.03 932.8299999999999 942.46 False True 1083.9284640582914 1340.6250221149905 1246.7114856895093 1102.5523671347044 1170.072633637663 1236.9212650461493 1194.3584859658536 961.8242348262531 1582.9443787924354 1063.4339213378025 1.019272041552621 1.2606566286962908 1.1723450424838275 1.0367850272706092 1.100277704293755 1.163138809311348 1.123114903522494 0.9044513396904584 1.4885216157117571 1.0 10.054514675910832 -11.958837356212454 1.9999318524866225 0.00010187489532746888 1.1343075921975263 0.07344218210134834 0.1485162876072155 2797908.7819781294 277101.3656630058 12635761.52455528 0.03524089070925739 1.0994174954729941e-12 11.958837356212454 1.1342057173021989 RFSEGVLQS(ph)PSQDQEK ddPTM_A459_Selumetinib_30min_R2 2 RFSEGVLQSPSQDQEK 16 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RFSEGVLQS(0.805)PS(0.195)QDQEK;RFSEGVLQS(1)PSQDQEK 161.55 2.3557e-05 18107500.0 49176.0 60718.0 63256.0 51307.0 61882.0 43178.0 35994.0 40648.0 29336.0 55956.0 True False 46442.99478712531 65374.87536085843 59186.17782792536 44318.89809048829 54107.829927900886 49125.377569141085 37667.792320757915 40766.27895036136 35204.019716325805 54340.40488885202 0.8546678090109912 1.2030619848081063 1.0891743988471358 0.8155790922268294 0.9957200362892613 0.9040303926631065 0.6931820327397946 0.7502019727998861 0.6478424256928557 1.0 15.729737694630183 -6.716466641405654 1.104745463295672 0.7526971588361794 1.0326590032239238 0.3403306836535126 0.13701266557621358 0.4914806478786248 1.2783614707041469 0.0710274306489073 0.06710103714037212 1.9210265120565816e-07 6.716466641405654 0.2799618443877444 RFSEGVLQSPS(ph)QDQEK ddPTM_A459_Selumetinib_30min_R1 1 RFSEGVLQSPSQDQEK 16 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RFSEGVLQS(0.316)PS(0.684)QDQEK 163.44 4.663600000000001e-05 0.0 1282.3 1027.2 1951.1 1345.0 1333.8 1003.3 983.9 1028.6 650.49 1052.1 True False 1312.175095078544 906.9349464676757 1686.1513366251452 1110.1209987769237 1213.1580255015165 993.2077129235132 909.6836308575656 1001.3181866363202 1103.8340200901462 1187.147283321841 1.1053178603137208 0.7639616071309338 1.4203387905728138 0.93511648838602 1.0219102907828697 0.8366339433000666 0.7662769764439972 0.8434658451430397 0.9298206175407568 1.0 10.213283218577475 -6.615833449258524 2.726762287746203 0.8585313310927378 1.0577468283980733 0.21401119339697539 0.16459933790237985 0.4086397179016152 6.158563259238829 0.05772512695566755 0.0582498931711877 2.4219576827820923e-07 6.615833449258524 0.1992154973053355 RFSFCCS(ph)PEPEAEAEAAAGPGPCER ddPTM_A459_Selumetinib_30min_R2 1 RFSFCCSPEPEAEAEAAAGPGPCER 25 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 RFS(0.098)FCCS(0.902)PEPEAEAEAAAGPGPCER 126.86 3.6225e-08 109030000.0 18922.0 20387.0 23901.0 26618.0 25169.0 25972.0 26621.0 24043.0 23251.0 23108.0 True False 17870.390990767566 21950.617345462982 22363.235681441198 22992.582481388832 22007.045206285125 29549.407249657965 27858.929248510773 24112.961149467083 27901.84968722018 22440.811998205612 0.7963344192802159 0.9781561089330535 0.9965430699757826 1.0245878127416843 0.9806706284979718 1.3167708571339023 1.2414403387336608 1.074513754288177 1.2433529450472307 1.0 14.453837258909259 -6.660227802129862 7.90923562231377 1.1835916612993755 0.9607165613829405 0.5394145227358371 0.10152749749190723 0.1914908717776781 13.316608026679052 0.033378329786947256 0.0333299860866629 2.1866143699699287e-07 6.660227802129862 -0.22287509991643506 RFTDEESR ddPTM_A459_Selumetinib_30min_R2 1 RFTDEESR 8 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;H0YF00;Q9NYF8-2;Q9NYF8 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 0 117.53 0.011929 2340800.0 9139.7 9990.9 8761.7 9800.9 11102.0 6657.4 8001.0 8486.1 6507.0 9778.3 False True 8631.75206311797 10757.169904193162 8197.981761017672 8466.000512504466 9707.267506860728 7574.396420139884 8373.062353680732 8510.793146050513 7808.581820770785 9495.975071925479 0.9089905984102092 1.1328136207935469 0.8633112133218127 0.891535671521917 1.02225073605763 0.7976428289637495 0.8817485608650555 0.8962526840674191 0.8223043722868004 1.0 13.213100432399205 -5.287978485226365 24.91357005248315 0.8933774470069915 1.0209021626387156 0.26412428190367854 0.08263924392596027 756.9921721239868 710624.8532238636 0.020556724299508992 0.04281456617469695 5.152541694334388e-06 5.287978485226365 0.12752471563172407 RFVEVGR ddPTM_A459_Selumetinib_30min_R1 1 RFVEVGR 7 1 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 93.195 0.035215 11002000.0 3077.3 4316.4 3495.5 4255.5 3692.0 4207.2 3555.0 2481.7 1710.4 2467.6 False True 3148.9951026165522 3811.033881360081 3020.830299407103 3512.3568106283997 3358.059251875541 4164.879387831959 3286.8434878530807 2415.8772543023097 2902.4238773266093 2784.340496459438 1.1309662401638048 1.3687384449589353 1.0849356618733899 1.2614681340499505 1.206051938024693 1.4958225810126355 1.1804746912357251 0.8676658825938619 1.0424098205723495 1.0 11.44311993353403 -7.613390354411337 5.832907806267605 0.9697441308746165 1.2595391182397861 0.5513281518955754 0.1160952563245356 0.1516910804281998 7.840663510475631 0.0546660360061986 0.03104928468062663 2.4356206393323428e-08 7.613390354411337 0.2897949873651696 RGAAGDWGER ddPTM_A459_Selumetinib_30min_R1 2 RGAAGDWGER 10 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 ; 118.23 0.0078146 7410000.0 3404.3 3745.5 4607.3 5548.4 4211.8 3348.3999999999996 3647.4 3682.3 2241.64 3230.7 False True 3483.6135663853115 3306.97511876429 3981.653966087356 4579.476096367197 3830.8434336536866 3314.7181361039497 3372.2736814614123 3584.6334422038913 3803.8993570921557 3645.3918146828933 0.9556211632324482 0.9071658924136687 1.0922430752299568 1.2562370052848648 1.050872890596789 0.9092899486834152 0.9250785245850893 0.9833328279735858 1.0434816202118045 1.0 11.831858171565655 -6.659099935491936 8.78318795557577 0.9684055318685839 1.0585191241992578 0.15575101701643523 0.09272040653213444 0.5418122247542335 42.08345188281625 0.03452281622699975 0.03449183063105812 2.1923004071145206e-07 6.659099935491936 0.09011359233067384 RGAAGDWGER ddPTM_A459_Selumetinib_30min_R2 4 RGAAGDWGER 10 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 ;;; 117.14 0.0082775 17878800.0 61326.8 68211.0 64956.5 74576.0 74101.0 50645.4 43739.8 50215.299999999996 39093.9 68493.5 False True 57918.50196663164 73442.5643670661 60777.269509289756 64418.620149224305 64791.76990865481 57621.34413683307 45773.78736876943 50361.418209409545 46913.772374831926 66515.91468751503 0.87074653094266 1.104135224060163 0.9137252309438298 0.9684692821538484 0.9740792141706225 0.8662790612973189 0.6881629394079598 0.7571333634364398 0.7053014695088842 1.0 16.0214119426266 -6.961713029151114 3.67416065604988 0.7673043333497112 0.9704400725445732 0.418284496243998 0.09794485250078289 0.18963859774697692 5.422980859157361 0.03486551581592791 0.029376981623271972 1.0921617710440917e-07 6.961713029151114 0.20313573919486205 RGADDDRPSWR ddPTM_A459_Selumetinib_30min_R1 1 RGADDDRPSWR 11 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 76.282 0.032774 16656000.0 1840.1 1861.1 3268.5 3652.5 2785.5 2128.5 2022.8 2053.3 1252.7 1058.1 False True 1882.9707497886823 1643.2015467980825 2824.6556525853575 3014.659440916516 2533.552016819969 2107.0892225233724 1870.218567434377 1998.8398139416277 2125.740406411976 1193.9174417667898 1.5771364785509907 1.3763108648169429 2.3658718381778217 2.5250149930428565 2.12204958918328 1.7648533716077115 1.5664555202969306 1.6741859562615091 1.7804752087935414 1.0 10.221487363750914 -8.921886450049445 0.5593043208774797 0.9828178154546542 1.9649822454662085 0.38615955257805823 0.3401249620257577 1.8549626225159042 1.1102708012468083 0.5098801324109372 0.18026293991115755 1.1970534701083063e-09 8.921886450049445 0.9821644300115543 RGAEDDRGPWR ddPTM_A459_Selumetinib_30min_R1 2 RGAEDDRGPWR 11 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 ; 75.652 0.033533 23015000.0 2908.5 2850.6 5383.9 5929.6 5002.4 3435.4 3627.5 3408.8 1637.06 2432.8999999999996 False True 2976.262391044174 2516.850426792012 4652.795951645803 4894.106672377434 4549.93380324545 3400.842995093631 3353.8747544829935 3318.3875506570957 2777.971253868275 2745.186413452816 1.0841749676666648 0.9168231397540652 1.6948925321955282 1.7827957505522434 1.6574225272821 1.238838637124154 1.2217293288526032 1.208802263625997 1.0119426645326512 1.0 11.422688404250499 -7.649994163877074 1.3218930964206197 1.0271560769436199 1.4195804858840997 0.25853838288070174 0.25803950059529546 0.7422242014268268 2.4174462035522573 0.23206170370885412 0.09753743321026995 2.2387512230849388e-08 7.649994163877074 0.3924244089404798 RGAEEEEEEEDDDS(ph)GEEMK ddPTM_A459_Selumetinib_30min_R1 1 RGAEEEEEEEDDDSGEEMK 19 1 Q08495;Q08495-2;Q08495-3;Q08495-4;E5RFK4 Q08495 DMTN Dematin 1 RGAEEEEEEEDDDS(1)GEEMK 167.36 3.0233000000000005e-09 15879000.0 3341.6 3634.3 4426.7 3988.8 2951.6 3327.5 3397.7 3142.4 2029.8 3133.3 True False 3419.4527783782733 3208.794466459767 3825.578454122564 3292.230959049364 2684.6283011473047 3294.028371128269 3141.4087534960345 3059.053344046251 3444.422349273591 3535.489575926554 0.96717942591646 0.9075955104799964 1.0820505539519192 0.9311952102663353 0.7593370715691441 0.9317036015485904 0.888535713663576 0.8652417941989144 0.9742419756310279 1.0 11.787694290320854 -5.995096365989948 24.982210239305886 0.8924178998855892 0.9826098181707488 0.19236118674505964 0.07350528977126015 196.19048932292367 999499.9393568635 0.020179079255707444 0.02981362947044979 1.0113550188935419e-06 5.995096365989948 0.0901919182851596 RGAEEEEEEEDDDS(ph)GEEMK ddPTM_A459_Selumetinib_30min_R2 2 RGAEEEEEEEDDDSGEEMK 19 1 Q08495;Q08495-2;Q08495-3;Q08495-4;E5RFK4 Q08495 DMTN Dematin 1 RGAEEEEEEEDDDS(1)GEEMK;RGAEEEEEEEDDDS(1)GEEMK 211.03 6.7673e-17 32000000.0 145527.0 119969.0 112926.0 118634.0 102622.0 71040.0 99042.0 101587.0 59177.1 99041.3 True False 137439.19193073842 129170.23653886557 105660.46410453242 102475.84454493495 89729.70690767976 80825.11516308729 103647.64924799975 101882.60135136673 71014.17354632472 96181.72032879895 1.428953354763255 1.342981141294778 1.0985503663620302 1.065439921376114 0.9329185067696557 0.8403375910389747 1.0776231584720921 1.0592719801962287 0.7383333683735483 1.0 16.553475110375572 -5.288194632766128 1.1969623215995522 0.9479217178800746 1.4915957470881926 0.7598859529194166 0.0967053098960818 0.3624356141362661 0.7693225629832006 0.03177427200758295 0.19695771322142375 5.149977922152961e-06 5.288194632766128 0.543674029208118 RGAPS(ph)SPATGVLPSPQGK ddPTM_A459_Selumetinib_30min_R2 3 RGAPSSPATGVLPSPQGK 18 1 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 1 RGAPS(0.611)S(0.388)PAT(0.001)GVLPSPQGK;RGAPS(0.498)S(0.498)PAT(0.003)GVLPSPQGK;RGAPS(0.5)S(0.5)PAT(0.001)GVLPSPQGK 101.89 0.0012486 21981600.0 126644.0 135257.0 143435.0 165597.0 159593.0 95895.0 87335.0 87668.0 78485.0 147499.0 True False 119605.63347610019 145630.77698019717 134206.54826021972 143042.40292924107 139543.50056047773 109103.66580186173 91396.25055101933 87923.09936578132 94184.19305412562 143240.32062157363 0.8349997609408186 1.0166884320577505 0.936932755231537 0.9986182822582795 0.9741914843177255 0.7616826416501994 0.63806231481762 0.6138152929583648 0.6575257067662581 1.0 17.128078127463937 -6.857330205041907 4.070569773622909 0.69583292197161 0.9579049070196708 0.47793871887368544 0.11209124550257159 0.1636699038263475 5.0240696932818265 0.03866680602618413 0.03424186112017298 1.3888962168512561e-07 6.857330205041907 0.26207198504806084 RGAPSSPATGVLPS(ph)PQGK ddPTM_A459_Selumetinib_30min_R2 1 RGAPSSPATGVLPSPQGK 18 1 Q5SRE5-2;Q5SRE5 Q5SRE5-2 NUP188 Nucleoporin NUP188 homolog 1 RGAPS(0.005)S(0.005)PAT(0.002)GVLPS(0.989)PQGK 54.768 0.035945 6958500.0 28109.0 32867.0 36642.0 40298.0 33193.0 28656.0 30631.0 26069.0 27683.0 42579.0 True False 26546.81430924245 35387.79321593821 34284.49361279313 34809.342882072575 29022.998590814994 32603.103886731835 32055.402194175014 26144.856474044736 33220.3735276468 41349.63363647208 0.6420084526656379 0.8558187849269049 0.8291365750470107 0.8418295356157474 0.7018925208859774 0.7884738272015681 0.7752282033739915 0.6322874999062603 0.803401883066385 1.0 15.335586926523112 -8.553055718511128 22.906736709482633 1.0000000021144833 0.7633779708477609 0.48380503331005076 0.0744916829169395 3315.4408358276546 2516680.978728567 0.07247035937102554 0.018711766394106547 2.798622242845505e-09 8.553055718511128 -0.23662203126672232 RGAS(ph)GSIFSK ddPTM_A459_Selumetinib_30min_R2 1 RGASGSIFSK 10 1 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 RGAS(0.754)GS(0.245)IFSK 64.104 0.047548 4855000.0 56336.0 50902.0 58658.0 58399.0 53963.0 48991.0 47587.0 45451.0 49960.0 52262.0 True False 53205.070650876325 54806.01972427316 54884.00814200147 50444.95545610589 47183.6855046591 55739.06555398095 49799.88979185162 45583.25488518187 59953.39599903312 50753.060267016706 1.048312562256529 1.0798564546833913 1.0813930796143414 0.9939293353092434 0.9296717332200505 1.0982404856127372 0.9812194482431136 0.8981380560179821 1.181276472465159 1.0 15.631207194929807 -5.7603722985435954 24.999999999915403 1.0064456765211987 1.0708542845392046 0.10578839232522863 0.07625724823245833 58.747110255168096 1376272.9695038942 0.020399283840481806 0.03290809037278886 1.736311738945191e-06 5.7603722985435954 0.06440860801800596 RGDDSFGDKYR ddPTM_A459_Selumetinib_30min_R1 1 RGDDSFGDKYR 11 2 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 67.207 0.047865 14257000.0 3695.8 3389.5 5780.4 5903.3 4583.7 3432.6 3647.4 3340.9 2206.7 3183.6 False True 3781.904949225049 2992.6557642641988 4995.453429464403 4872.399473665288 4169.105144317965 3398.071160551432 3372.2736814614123 3252.288479227382 3744.6087290087894 3592.246070890045 1.0527967390296324 0.8330876296352141 1.3906211687293146 1.3563657326119816 1.1605845095363951 0.9459460998754736 0.9387646655914832 0.9053635010091522 1.042414315476165 1.0 11.81067046355336 -6.758414168050077 23.476257992043806 0.9588495877057185 1.1644690634713588 0.29238782902525795 0.1491226512459248 51.03421843958531 396035.64312349213 0.05546063782306238 0.053136538679866493 1.744158030719844e-07 6.758414168050077 0.20561947576564032 RGDDWNDR ddPTM_A459_Selumetinib_30min_R2 3 RGDDWNDR 8 1 C9JUL9;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;A0A087X0F4 C9JUL9;Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 0 ;; 177.7 0.00032579 25977000.0 52314.9 38649.8 54600.5 57906.9 61653.0 53412.0 69990.0 78621.0 70377.0 54540.3 False True 49407.44729113759 41614.115381305506 51087.5632745295 50019.88032502573 53907.59895518685 60769.018174138735 73244.67368255388 78849.7740935928 84454.36649767742 52965.579826282425 0.9328217958376956 0.7856822396317065 0.9645426981463721 0.9443846454448709 1.0177854963920734 1.1473303676359285 1.3828730644086829 1.4886984028534358 1.5945141500323898 1.0 15.69276749496622 -6.937305733655102 1.5656857928311656 1.41609880206265 0.9029029433395274 0.6440908388867663 0.1529468571900858 0.21712551003746788 1.0886047399475607 0.0704942643689048 0.055447995569868666 1.1552986512979339e-07 6.937305733655102 -0.5131958587231226 RGDDWNDREWDR ddPTM_A459_Selumetinib_30min_R1 3 RGDDWNDREWDR 12 2 C9JUL9;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 C9JUL9;Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 0 ;; 120.86 0.0024923 63767500.0 5117.6 4402.9 6333.6 6735.0 5604.799999999999 4662.1 3837.7000000000003 3591.3 2567.48 2772.75 False True 5236.830122883849 3887.406421147323 5473.531907974487 5558.858681607867 5097.846829607812 4615.203506848116 3548.2191992500043 3496.047057813551 4356.826038680149 3128.659471372148 1.6738255379985834 1.242515031347406 1.7494815137468251 1.7767541442181618 1.6294029044241207 1.475137690463964 1.1341020752552047 1.117426517587827 1.3925536091562434 1.0 11.611328926399269 -7.11602578077444 3.346147236278087 1.1704628210055499 1.607770478147666 0.6277829644239519 0.16473533748279703 0.1822012056914568 3.7979654280759987 0.06941426443407668 0.052755433815091096 7.655511605875499e-08 7.11602578077444 0.43730765714211617 RGDDWNDREWDR ddPTM_A459_Selumetinib_30min_R2 2 RGDDWNDREWDR 12 2 C9JUL9;Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5 C9JUL9;Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 0 ; 94.82 0.0118 27792000.0 54443.0 33097.0 37134.0 29972.0 35788.0 38797.0 32442.0 32455.0 32416.0 34498.0 False True 51417.27601259689 35635.43347637162 34744.838868442195 25889.761895416133 31291.991491220648 44140.934585899435 33950.61728260343 32549.438676785496 38900.10577871612 33501.95310343161 1.5347545814375285 1.063682268503966 1.0370989046869412 0.772783658776128 0.9340348425243126 1.3175630223593762 1.0133921797868515 0.9715683911410959 1.1611294917230237 1.0 15.031957584089984 -4.758669217779943 4.431226661823358 1.0239581158582318 1.5810040932552158 0.5616609454450233 0.13409279775956864 0.16942270071524113 7.134399459893631 0.0353843434487666 0.30483085833738605 1.7431340332821776e-05 4.758669217779943 0.557045977396984 RGDLPFVVPR ddPTM_A459_Selumetinib_30min_R1 2 RGDLPFVVPR 10 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ; 164.65 0.00050316 28831000.0 10184.599999999999 10812.4 12216.8 14136.900000000001 13007.1 12098.5 10076.3 10346.9 6682.8 8728.9 False True 10421.881364218154 9546.479181451616 10557.82566207887 11668.155797479178 11830.610101590026 11976.800074559085 9316.236578524333 10072.466600532129 11340.22350759955 9849.339341686169 1.0581299925477 0.9692507131973072 1.0719323698589729 1.184663802585731 1.2011577316174256 1.2160003487613316 0.9458742617481417 1.022654033037688 1.1513689511745615 1.0 13.265811241673884 -10.680557830107722 13.531564373189592 0.9999999999996338 1.0904302904233287 0.08346779646395597 0.09065424408669462 0.0 0.0 0.0964427248894046 0.023390796561258857 2.0866142544811056e-11 10.680557830107722 0.09043029042369488 RGDLPFVVPR ddPTM_A459_Selumetinib_30min_R2 2 RGDLPFVVPR 10 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ; 158.08 0.00065132 7950300.0 41422.0 45915.0 47604.0 48686.0 48108.0 39132.0 38893.0 34758.0 34236.0 47222.0 False True 39119.931065403965 49436.53286000553 44541.21046731629 42054.88281196548 42064.24294902322 44522.0777950722 40701.60156501744 34859.140025503344 41084.156633764986 45858.578162509344 0.8530559086846176 1.0780214921800881 0.9712732546891295 0.9170559685242599 0.91726007727409 0.9708560443653316 0.8875460861604323 0.7601443704157765 0.8958881474295778 1.0 15.484904004644864 -7.376484629321746 4.9780250098793 0.8629592467567615 0.9545844119147181 0.12538507938612775 0.07712555454343174 0.34289786813924045 12.678759186096025 0.03243835871524003 0.021445540675466387 4.2025740128786594e-08 7.376484629321746 0.0916251651579566 RGDSES(ph)EEDEQDS(ph)EEVR ddPTM_A459_Selumetinib_30min_R1 1 RGDSESEEDEQDSEEVR 17 1 Q9NZ63 Q9NZ63 C9orf78 Uncharacterized protein C9orf78 2 RGDS(0.505)ES(0.508)EEDEQDS(0.988)EEVR 130.29 0.0026937 0.0 199.57 207.6 241.92 228.26 279.68 187.01 171.72 261.78 0.0 219.88 True False 204.21959270437884 183.29409548937832 209.0685927714393 188.39867597087033 254.38299338151452 185.12884919149428 158.7670221474349 254.83674401872065 0.0 248.10373981257146 0.8231217830841863 0.7387800588086532 0.8426660272407783 0.7593544382410157 1.0253089839503697 0.7461751658050331 0.6399219224481442 1.0271378585878455 0.0 1.0 7.954799671753905 -8.207427912122126 24.999999461975953 0.4999848475875622 0.8186534635477949 0.2104626220032143 0.2517665366661809 388.8555282535505 179987.77536671417 0.1537978511169652 0.05813004170177133 6.202575907198722e-09 8.207427912122126 0.3186686159602327 RGEAHLAVNDFELAR ddPTM_A459_Selumetinib_30min_R1 2 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 ; 158.31 9.9393e-05 11441400.0 1881.4299999999998 2174.8 2455.7 2611.9 2225.53 2020.06 1827.4499999999998 1854.3400000000001 1181.13 1593.44 False True 1925.2636583745027 1920.1734049629106 2122.229428194543 2155.7806964352767 2024.231204449234 1999.7400304677296 1689.6039752115641 1805.1568794547884 2004.291343677959 1797.9735454199742 1.0707964326164743 1.0679653267725875 1.1803451911740048 1.199005792897651 1.1258403715703225 1.1122188285593637 0.9397268271913884 1.0039952390028832 1.1147501857207764 1.0 10.812156078499882 -7.103272164194813 6.923710158533902 1.0152597222367898 1.1309223759850582 0.494269370068087 0.05537819695903941 0.23445131167520059 13.665630323618279 0.022727804953206348 0.017602887983532576 7.8836590867126e-08 7.103272164194813 0.11566265374826834 RGEECPYR ddPTM_A459_Selumetinib_30min_R2 2 RGEECPYR 8 1 E5RJW4;Q9NW64-2;Q9NW64 E5RJW4 RBM22 Pre-mRNA-splicing factor RBM22 0 ; 96.668 0.028267 4112300.0 11614.8 9321.8 9619.3 11879.3 10677.7 9172.8 11452.099999999999 10060.7 10314.4 10930.8 False True 10969.295913728309 10036.75208568877 9000.40471070195 10261.31884706448 9336.271866150853 10436.269937612147 11984.645341905649 10089.974971361462 12377.568208415283 10615.19940237086 1.0333574997449755 0.9455076353485271 0.847879005333781 0.9666628442959496 0.8795192169508975 0.9831440316873605 1.1290080277935175 0.9505214729275749 1.166023146550672 1.0 13.373843851509614 -7.013361849513501 12.041343782085509 1.0571138978388765 0.9320633971855193 0.4017162973046028 0.07289734527441734 0.7723769489926612 691.8302894453609 0.02564602611786899 0.020946806383346617 9.697016855020234e-08 7.013361849513501 -0.1250505006533572 RGEEGHDPKEPEQLR ddPTM_A459_Selumetinib_30min_R2 2 RGEEGHDPKEPEQLR 15 2 P51991 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 ; 69.314 0.026991 28361000.0 83040.0 81606.0 80014.0 91746.0 83863.0 60233.0 57133.0 58088.0 42291.0 81359.0 False True 78424.96923545802 87864.91779535254 74865.98635265627 79250.03652932223 73327.38019526766 68529.5490092657 59789.79770689179 58257.02646301393 50750.381709269655 79009.95427393174 0.9925960590175062 1.1120740241251141 0.9475513185729976 1.0030386330127228 0.9280777450020754 0.8673533561564924 0.7567375308128563 0.7373378076012258 0.6423289593778951 1.0 16.26974680596509 -6.736456688349754 1.3231983362027389 0.7600450236533053 1.023525554282242 0.5423151903887627 0.09365461292575769 0.29205022956730825 1.0723938265306967 0.042471390812902944 0.03920410013953867 1.8346081211880835e-07 6.736456688349754 0.2634805306289366 RGEGDAPFSEPGTT(ph)STQRPSSPETATK ddPTM_A459_Selumetinib_30min_R1 1 RGEGDAPFSEPGTTSTQRPSSPETATK 27 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RGEGDAPFSEPGT(0.065)T(0.511)S(0.144)T(0.065)QRPS(0.105)S(0.105)PET(0.004)AT(0.001)K 87.35700000000001 6.3572e-05 471030000.0 9204.9 10469.0 8856.0 9430.9 8682.5 8799.6 9623.3 8567.3 4712.1 7416.8 True False 9419.356260382508 9243.284613093942 7653.403842525904 7783.970354918428 7897.169408019879 8711.084013397542 8897.40673323672 8340.067373487605 7996.08954183274 8368.818525749868 1.1255299934393679 1.104490984558148 0.9145142553847097 0.9301158020057513 0.94364209042426 1.0408977069576264 1.0631616285931458 0.9965644908927349 0.9554621739292966 1.0 13.03080824825569 -5.157640156684552 6.634320550457393 0.982589902499106 1.1190930245996638 0.5899437933539022 0.04489266856223068 0.18706243973457062 10.220407421838512 0.013039665922344127 0.03537816608176518 6.9560043242885706e-06 5.157640156684552 0.1365031221005577 RGEGDAPFSEPGTT(ph)STQRPSSPETATK ddPTM_A459_Selumetinib_30min_R2 2 RGEGDAPFSEPGTTSTQRPSSPETATK 27 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RGEGDAPFSEPGT(0.188)T(0.383)S(0.383)T(0.034)QRPS(0.006)S(0.006)PETATK;RGEGDAPFS(0.001)EPGT(0.093)T(0.369)S(0.141)T(0.141)QRPS(0.125)S(0.125)PET(0.005)ATK 94.72 3.6653e-06 542710000.0 342180.0 250530.0 317611.0 322137.0 315705.0 254732.0 245939.0 262155.0 211011.0 282099.0 True False 323163.0054550707 269744.8454190832 297176.25404871 278261.38488267973 276043.3154614904 289819.0207731357 257375.6508188835 262917.82764790335 253219.0961399518 273954.06888877455 1.1796247698232765 0.984635294935516 1.0847667101793026 1.0157227670002373 1.0076262658962882 1.0579109919729002 0.9394846802709037 0.9597149942483537 0.9243122292984043 1.0 18.063574505794023 -1.5228787452810844 0.3173732158407389 0.9591933011516454 2.5928705249045305 0.5385705463648129 0.048981086846318356 45.96491024479593 0.6562128171138123 0.046173085876757405 43.461744255121566 0.02999999999994841 1.5228787452810844 1.6336772237528852 RGEGDAPFSEPGTTST(ph)QRPSSPETATK ddPTM_A459_Selumetinib_30min_R1 1 RGEGDAPFSEPGTTSTQRPSSPETATK 27 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RGEGDAPFSEPGT(0.001)T(0.002)S(0.118)T(0.371)QRPS(0.253)S(0.253)PET(0.002)ATK 86.617 0.00017554 6031800.0 1119.8 1050.1 1259.0 1524.8 927.18 870.03 1223.3 1061.1 645.16 1005.9 True False 1145.8891612485013 927.1538038217541 1088.0347151919732 1258.5223040409312 843.3167327069241 861.278288124035 1131.0254961155201 1032.9561810614425 1094.7893993779446 1135.0170632957324 1.0095787969224002 0.8168633175695096 0.9586064830009363 1.1088135542091133 0.7429991671298735 0.7588240881799203 0.9964832535921336 0.9100798696911769 0.9645576571325022 1.0 10.148498271118447 -8.361505501776339 1.413663139584881 0.9985660137550907 0.9063563085981143 0.06551734012458499 0.108938612776077 1.2587747077580633 5.195937180951058 0.10725883727356117 0.03270312712485314 4.350052498152248e-09 8.361505501776339 -0.09220970515697635 RGEGDAPFSEPGTTSTQRPS(ph)SPETATK ddPTM_A459_Selumetinib_30min_R1 2 RGEGDAPFSEPGTTSTQRPSSPETATK 27 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RGEGDAPFSEPGTTS(0.001)T(0.002)QRPS(0.484)S(0.484)PET(0.027)AT(0.002)K;RGEGDAPFSEPGT(0.003)T(0.003)S(0.015)T(0.046)QRPS(0.46)S(0.46)PET(0.01)AT(0.001)K 110.06 1.3326e-09 600710000.0 4226.7 5241.9 3924.7 4824.5 4182.0 4044.2999999999997 4462.6 4088.1 2088.74 3975.6 True False 4325.173886273478 4628.175911106805 3391.747296833944 3981.9916420812383 3803.738838392067 4003.618013930593 4125.982489140126 3979.67030797972 3544.439224466312 4485.906985623338 0.9641693196348062 1.0317146400804602 0.7560895283170131 0.8876670102262322 0.847930831063257 0.8924879688236048 0.9197655016841151 0.8871495375927251 0.7901276677884117 1.0 12.131183991405678 -5.235393362248878 24.99560576473465 0.8706662381983069 0.9979420029464946 0.37067862631720105 0.0652589103137554 748.5370799908326 718346.7050856047 0.015705876674238922 0.041522258870734144 5.815762164537929e-06 5.235393362248878 0.1272757647481877 RGEGDAPFSEPGTTSTQRPS(ph)SPETATK ddPTM_A459_Selumetinib_30min_R2 3 RGEGDAPFSEPGTTSTQRPSSPETATK 27 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RGEGDAPFS(0.002)EPGT(0.002)T(0.005)S(0.045)T(0.112)QRPS(0.413)S(0.413)PET(0.006)AT(0.001)K;RGEGDAPFS(0.002)EPGT(0.006)T(0.037)S(0.094)T(0.094)QRPS(0.38)S(0.38)PET(0.008)AT(0.001)K;RGEGDAPFSEPGT(0.002)T(0.019)S(0.051)T(0.023)QRPS(0.403)S(0.403)PET(0.06)AT(0.039)K 79.236 4.3727e-05 372981300.0 159154.0 118296.0 156314.0 176213.0 163760.0 147629.5 132026.8 126591.6 93015.8 137876.0 True False 150308.85782394136 127368.92281840801 146256.92742181517 152212.48541561989 143187.00476702518 167964.12357782913 138166.30780614115 126959.96059763253 111621.5590786 133895.16163513032 1.1225861785322686 0.9512585911468066 1.0923242157201405 1.1368034778613212 1.0693964069980026 1.254445056316061 1.0318991823068997 0.948204244628372 0.8336489363429965 1.0 17.030744303574615 -7.696970229075933 3.424146053985559 0.9134829091565743 1.0993874036940885 0.4905846937437609 0.08016829133592014 0.20091554641749185 4.7097152602409675 0.044683033121411475 0.02265543171337284 2.009230540814324e-08 7.696970229075933 0.18590449453751423 RGEGDAPFSEPGTTSTQRPSS(ph)PETATK ddPTM_A459_Selumetinib_30min_R2 1 RGEGDAPFSEPGTTSTQRPSSPETATK 27 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RGEGDAPFSEPGT(0.001)T(0.001)S(0.001)T(0.004)QRPS(0.171)S(0.817)PET(0.004)ATK 93.404 1.0568e-05 6767700.0 20667.0 18327.0 19789.0 23701.0 23916.0 17142.0 17826.0 19386.0 14612.0 20050.0 True False 19518.41087655602 19732.621969406988 18515.7972846341 20472.882913494504 20911.45826824725 19503.154900417267 18654.944321548894 19442.41005047493 17534.80829339215 19471.104403843798 1.0024295731629318 1.0134310596943625 0.9509371888005946 1.0514494960775285 1.0739739171712885 1.0016460543741494 0.9580835239045924 0.9985263109491004 0.9005554040340207 1.0 14.249047095798778 -7.141322839157365 4.621351311505078 0.9643887349166155 1.0179943071273325 0.29377573019617054 0.03952781448842831 0.3161413798075752 10.563235343116661 0.015966297957465802 0.012246643361847366 7.222327217422472e-08 7.141322839157365 0.053605572210717045 RGESMQPNR ddPTM_A459_Selumetinib_30min_R2 2 RGESMQPNR 9 1 K7ENA8;O75821;K7EL20;K7EP16;K7ER90 K7ENA8 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 ; 182.39 0.0021057 2635400.0 6606.2 6362.4 6043.4 4442.6 5620.0 6331.5 7260.200000000001 9794.3 6844.9 8741.9 False True 6239.053850713915 6850.3756216595675 5654.574223556406 3837.510216087536 4913.965356562536 7203.60665336553 7597.813685813381 9822.799791466354 8214.07126248563 8489.498632816065 0.7349142888835531 0.8069234613195548 0.6660669219850877 0.4520302531475394 0.5788286881356758 0.8485314580910664 0.8949661239645077 1.1570529917392798 0.9675566977223161 1.0 13.0514636392286 -7.162892838029188 2.0633126018447854 1.0361616950493615 0.650115516168925 0.711848600459208 0.10709284285766649 0.1930303536234229 1.6112531869343818 0.05591026756740598 0.0386713899320566 6.872379947650299e-08 7.162892838029188 -0.38604617888043646 RGEVPAELR ddPTM_A459_Selumetinib_30min_R2 2 RGEVPAELR 9 1 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0;Q9UNZ2-6 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 0 ; 128.03 0.0059811000000000005 6915200.0 36612.0 30625.0 33071.0 39430.0 42403.0 33383.0 32944.0 36800.0 30998.0 33083.0 False True 34577.25160944836 32973.83902510443 30943.247864982288 34059.5659794561 37075.95605237032 37981.20522929815 34475.961277297574 36907.08190743204 37198.46615648578 32127.807830043115 1.0762406135010163 1.0263332997861803 0.9631297606320612 1.0601272940759616 1.1540144988572836 1.1821909988449772 1.0730878826117314 1.1487581755553133 1.1578277096671696 1.0 14.971534924609607 -6.063843113489137 5.022518006914457 1.1268430524088247 1.0205394610466163 0.38446132507469655 0.055436790080915246 0.19602639627048163 9.836976482679392 0.016008758670632308 0.021338602473679743 8.632903503716325e-07 6.063843113489137 -0.10630359136220835 RGFS(ph)DSGGGPPAK ddPTM_A459_Selumetinib_30min_R1 2 RGFSDSGGGPPAK 13 1 Q9H307;G3V5F0;G3V579 Q9H307 PNN Pinin 1 RGFS(0.991)DS(0.009)GGGPPAK;RGFS(0.904)DS(0.096)GGGPPAK 134.02 0.002269 10065600.0 5034.0 5619.48 6393.5 7467.2 6134.799999999999 4856.6 5198.16 5299.4 3326.27 3642.33 True False 5151.28240554113 4961.548669174622 5525.297816981634 6163.193696704117 5579.908423186909 4807.747013439984 4806.058606137372 5158.842697122806 5644.437248851251 4109.858534798633 1.2533965249471837 1.207231009818132 1.3444009739503973 1.4996121264320088 1.3576886834282007 1.1698083943114468 1.169397575474663 1.2552360752668996 1.3733896680528461 1.0 12.004873020501664 -6.757062017479978 24.992639538036478 1.208008044321634 1.3354573498828426 0.2715091106777836 0.11247039485701825 178.2704954483712 1017838.1026613978 0.039702630883663555 0.03838806313615747 1.7495968274396022e-07 6.757062017479978 0.1274493055612087 RGFS(ph)DSGGGPPAK ddPTM_A459_Selumetinib_30min_R2 1 RGFSDSGGGPPAK 13 1 Q9H307;G3V5F0;G3V579 Q9H307 PNN Pinin 1 RGFS(0.995)DS(0.005)GGGPPAK 93.181 0.018334 0.0 13752.0 12310.0 15003.0 16387.0 17021.0 7766.1 9290.9 11779.0 7824.8 12275.0 True False 12987.718893617779 13254.137417111358 14037.72331403131 14155.062330848248 14882.669810329347 8835.809781363349 9722.945259569093 11813.274939881572 9389.978643179236 11920.588855719832 1.0895199096969028 1.111869352892886 1.1776031774886369 1.1874465684684907 1.2484844490872802 0.7412225929697827 0.8156430338509453 0.9909975994359735 0.7877109727405506 1.0 13.54116788365855 -6.757242126868978 24.99999860817201 0.8633351936308992 1.1623160998279947 0.7472079242163323 0.08603169418666348 53.99540256428492 321611.5241975932 0.029071583327129447 0.028086487602068753 1.7488713899883988e-07 6.757242126868978 0.2989809061970955 RGFSDS(ph)GGGPPAK ddPTM_A459_Selumetinib_30min_R1 1 RGFSDSGGGPPAK 13 1 Q9H307;G3V5F0;G3V579 Q9H307 PNN Pinin 1 RGFS(0.334)DS(0.666)GGGPPAK 124.42 0.0040648 7007800.0 2319.1 3079.5 3507.1 4001.5 2869.6 2096.3 2674.9 3094.5 1401.4 1979.7 True False 2373.1305178169314 2718.950708379291 3030.8550831213415 3302.7131424578856 2610.04518666903 2075.213125288111 2473.1301394256543 3012.423807647378 2378.0734457936796 2233.813778910987 1.0623672126213954 1.217178770248617 1.3568074079115595 1.4785087161867185 1.168425591833112 0.9290000558147707 1.1071335322460663 1.348556373000785 1.0645799879312325 1.0 11.125293205738597 -6.512047653477075 24.90936982740777 1.1056069650037719 1.2853441836351698 0.2804109512086391 0.14136391752370453 754.561331840021 1735346.4304343462 0.04821630892270552 0.051421431792585966 3.0757593048868106e-07 6.512047653477075 0.1797372186313979 RGGADVNIR ddPTM_A459_Selumetinib_30min_R2 4 RGGADVNIR 9 1 P08621;P08621-4;P08621-2 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 ;;; 132.88 0.0044082 5698750.0 16934.9 21407.399999999998 26772.5 27427.899999999998 25579.1 17178.6 13911.2 13800.4 13516.699999999999 26626.2 False True 15993.726053776007 23049.278744359843 25049.98649769401 23692.172704233413 22365.624777944628 19544.79621819554 14558.09836451985 13840.556879220796 16220.417688153153 25857.432422824222 0.618534964811836 0.8913985877427785 0.9687731592245221 0.9162616116254626 0.8649592276688155 0.7558676321220297 0.5630140737279659 0.535264161301793 0.6273019464158195 1.0 14.65829140586688 -6.9762600090914075 3.719595027020239 0.6430363396202532 0.8631843416278651 0.20785719090527144 0.14861938898020657 0.2748962844115126 8.249757915654145 0.055565664145058896 0.046382741132246004 1.0561849892689491e-07 6.9762600090914075 0.22014800200761186 RGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDR ddPTM_A459_Selumetinib_30min_R1 2 RGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDR 32 1 P31942;P31942-4;P31942-3;P31942-5 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 ; 238.1 4.2366999999999986e-67 33049000.0 1333.31 1159.8600000000001 1624.1100000000001 2337.0 1237.94 1286.7199999999998 1389.9299999999998 987.5799999999999 855.0799999999999 959.4100000000001 False True 1364.3735288303628 1024.0630519957149 1403.5647825976446 1928.8868209231741 1125.9685455760584 1273.7767650482836 1285.0864610609374 961.3861702880588 1451.0083074277588 1082.5596189447845 1.260321838126822 0.9459645769846019 1.296524235742099 1.7817834576199505 1.040098416633706 1.1766342867008899 1.1870814674517087 0.8880676440020565 1.3403495586156415 1.0 10.080230764198388 RGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDR ddPTM_A459_Selumetinib_30min_R2 1 RGGDGYDGGYGGFDDYGGYNNYGYGNDGFDDR 32 1 P31942;P31942-4;P31942-3;P31942-5 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 80.608 1.0215e-05 3151100.0 8604.4 6307.8 6307.9 5600.9 6519.9 5419.7 6637.1 4981.7 6519.4 5187.3 False True 8126.201894142288 6791.587977226246 5902.056581522232 4838.0477579085855 5700.81187335446 6166.214479861821 6945.738301164152 4996.195922235171 7823.462167255743 5037.529170776006 1.6131324740081827 1.3481982430247716 1.1716173507761642 0.9604009413931212 1.1316682603897017 1.2240553395965639 1.3787986264095808 0.9917949361403959 1.5530356057572126 1.0 12.298500572528406 -4.8805656582028405 2.4457359588300416 1.1767083907924514 1.6621040591166745 0.37828750004342326 0.1731379366202824 0.4445793898829798 3.960340211120697 0.0442009999045781 0.4216417049776148 1.3165408582898062e-05 4.8805656582028405 0.4853956683242231 RGGGSGGGEES(ph)EGEEVDED ddPTM_A459_Selumetinib_30min_R1 1 RGGGSGGGEESEGEEVDED 19 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 RGGGSGGGEES(1)EGEEVDED 139.46 0.00023734 29570000.0 4417.4 4668.2 5254.0 5183.5 4588.8 3796.7 4562.9 3898.6 2717.8 3731.5 True False 4520.316825235874 4121.644973812697 4540.535658156179 4278.299031345858 4173.7438502184405 3758.508645127782 4218.716779388135 3795.196463562475 4611.908099741732 4210.474372887986 1.073588490252552 0.978902757454771 1.0783905223111008 1.0161085551059537 0.9912763932477395 0.892656815424292 1.0019575956935456 0.9013702797956541 1.0953416863046719 1.0 12.039767068276566 -6.236325621797621 3.3238112678810117 0.971333928391273 1.0376277943690888 0.17828282267166762 0.05916355140434241 0.3884484445760781 8.944308000807691 0.017687065241774082 0.022382050467548046 5.803291398820479e-07 6.236325621797621 0.06629386597781584 RGGGSGGGEES(ph)EGEEVDED ddPTM_A459_Selumetinib_30min_R2 1 RGGGSGGGEESEGEEVDED 19 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 RGGGS(0.015)GGGEES(0.985)EGEEVDED 81.01 0.010743 27098000.0 8727.9 5816.8 8436.1 8711.9 8368.2 5259.8 5149.5 6515.2 5690.2 6297.2 True False 8242.83825855196 6262.929856040081 7893.330510531193 7525.324191134245 7316.911903342814 5984.2897062895045 5388.961953540667 6534.1581533505805 6828.398997471948 6115.383473909484 1.3478857529898156 1.0241270858581617 1.2907335319538173 1.2305563867319353 1.1964763836249193 0.9785632792809683 0.8812140688367291 1.0684788911811902 1.1165937551756902 1.0 12.578227252517191 -6.737023659248943 8.069963896821118 1.0052069015822287 1.2124356885894303 0.5395186639596741 0.0964470117219677 0.16162991437096114 43.047238811187356 0.032274728782082145 0.03163612302230686 1.832214605302245e-07 6.737023659248943 0.2072287870072016 RGGIPAS(ph)PIDPFQSR ddPTM_A459_Selumetinib_30min_R1 2 RGGIPASPIDPFQSR 15 1 Q96LD4-2;Q96LD4 Q96LD4-2 TRIM47 Tripartite motif-containing protein 47 1 RGGIPAS(0.999)PIDPFQS(0.001)R;RGGIPAS(1)PIDPFQSR 101.38 0.0035828 37575000.0 6245.6 6263.0 8772.8 9665.900000000001 7456.5 6309.3 7770.3 7014.1 3944.1 4512.2 True False 6391.110328177927 5529.725048410295 7581.501945541018 7977.932016414769 6782.060891551998 6245.8341703860515 7184.18001509558 6828.063282992235 6692.849634333424 5091.38482254996 1.255279369155407 1.086094499068094 1.489084445544604 1.5669473619593965 1.3320660543107963 1.2267456474165903 1.411046358797422 1.341101394015721 1.3145440518835874 1.0 12.313842397720656 -8.911373614918952 2.721928037701417 1.000005063992474 1.34091252571681 0.38436989531430865 0.1278097786811026 5.755011312714176 39.08431427082324 0.13297419380247288 0.035581970066932186 1.2263837436338e-09 8.911373614918952 0.34090746172433595 RGGIPAS(ph)PIDPFQSR ddPTM_A459_Selumetinib_30min_R2 1 RGGIPASPIDPFQSR 15 1 Q96LD4-2;Q96LD4 Q96LD4-2 TRIM47 Tripartite motif-containing protein 47 1 RGGIPAS(1)PIDPFQSR 82.859 0.012622 21852000.0 31465.0 43567.0 39108.0 37739.0 39663.0 29843.0 20915.0 24590.0 23943.0 49361.0 True False 29716.301264374855 46908.44881001547 36591.833857570906 32598.88309659378 34680.17934828112 33953.60236221863 21887.588942286275 24661.552828906366 28732.26902331568 47935.8196747199 0.6199184965652409 0.9785677835139588 0.7633505404908822 0.6800526895712097 0.723471082451742 0.7083137952499615 0.4566019542548725 0.5144702436769267 0.5993903769307678 1.0 15.548816481329315 -6.30944503307451 1.2180825687994246 0.6134951084048929 0.8000452032270285 0.06825882426672814 0.16227854629578176 0.8100319579704901 2.471325230656727 0.06574757629828004 0.0911599376573151 4.904050874858717e-07 6.30944503307451 0.1865500948221357 RGGIPASPIDPFQS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 RGGIPASPIDPFQSR 15 1 Q96LD4-2;Q96LD4 Q96LD4-2 TRIM47 Tripartite motif-containing protein 47 1 RGGIPAS(0.102)PIDPFQS(0.898)R 64.331 0.035526 26879000.0 2782.7 2757.8 3964.8 4200.7 3323.4 3201.1 2806.5 2977.1 2164.9 2368.3 True False 2847.531495808362 2434.915493933562 3426.401937087477 3467.1266019049986 3022.7990567939264 3168.8998403662526 2594.8034454738868 2898.1376370163216 3673.677181959996 2672.2943741955287 1.065575530639504 0.9111703850615532 1.2821947949199892 1.2974343827478765 1.1311624520049046 1.1858348657116875 0.9710020986198536 1.0845128684180916 1.3747277311340091 1.0 11.383863225408037 -5.253636707132619 24.767388684362118 1.1660912239915049 0.9883729584156252 0.23944451904077646 0.12652733872734095 756.4892625092909 2401246.2938038367 0.03287201605822547 0.08344801271189393 5.5765203691064275e-06 5.253636707132619 -0.17771826557587966 RGGPNYQEGLR ddPTM_A459_Selumetinib_30min_R1 1 RGGPNYQEGLR 11 1 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 129.0 0.0036106 3589400.0 1210.8 1486.7 1585.7 2214.5 1666.7 1183.0 1395.5 1380.8 927.58 974.27 False True 1239.0092841933244 1312.6364728519206 1370.3706496266184 1827.7791463133806 1515.947279279785 1171.1000940780593 1290.2363114765042 1344.1766985294876 1574.0355122372646 1099.3270446934416 1.1270615875176933 1.194036369057001 1.2465541134838176 1.6626345682444983 1.3789775177436139 1.0652881685491804 1.1736601202568426 1.222726853685588 1.4318173284604312 1.0 10.102404929882288 -6.739183522116345 24.992078837995912 1.1923039574084757 1.3295009842997585 0.14649621806390756 0.17070212464277323 543.0722585590086 609838.3397113124 0.06035652498210468 0.060311571772777794 1.8231251318889974e-07 6.739183522116345 0.13719702689128277 RGILT(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 RGILTLK 7 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38;P0CG39 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member I;POTE ankyrin domain family member J 1 RGILT(1)LK 90.906 0.036237 1689900.0 23654.0 24140.0 22141.0 22845.0 20517.0 14927.0 14555.0 17870.0 14429.0 19802.0 True False 22339.40537446443 25991.460377665986 20716.472165298084 19733.471590176865 17939.47103569281 16983.058756185295 15231.836340185357 17921.998741462237 17315.203179944936 19230.264808225173 1.1616795502945656 1.3515913918433882 1.0772848097462095 1.0261674390326887 0.9328769631929217 0.8831422201175981 0.7920762658281436 0.9319683800608215 0.9004141831962124 1.0 14.231091008835831 -5.736689010546832 1.458913784570154 0.8943924454520256 1.2609759386803243 0.7792569802661002 0.07156690068938845 0.17548027562733123 0.7483334976117474 0.022849682451206433 0.05492931175380613 1.8336269753846896e-06 5.736689010546832 0.36658349322829875 RGILTLK ddPTM_A459_Selumetinib_30min_R1 1 RGILTLK 7 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38;P0CG39 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 106.36 0.023213 23642000.0 7944.6 7568.9 8876.7 9900.0 9337.9 8122.1 7664.0 7511.4 4668.0 6104.7 False True 8129.693722499409 6682.729669313853 7671.2928962228625 8171.150846016013 8493.288593740142 8040.399048276759 7085.898309678199 7312.173271534182 7921.255062769306 6888.297709813555 1.18021811265754 0.9701569169684935 1.1136703463460642 1.18623659868458 1.2330025430869522 1.1672548700707053 1.0286864198077745 1.0615356042345185 1.1499582910715556 1.0 12.749931781518503 -10.500629852148807 5.5405235127811 0.9999997427690454 1.1186088943525396 0.18437422437649187 0.07629555386209799 2.600566638017119e-07 4.794456917810275e-08 0.07922945249916931 0.019215923264056505 3.1576947703506265e-11 10.500629852148807 0.11860915158349428 RGILTLK ddPTM_A459_Selumetinib_30min_R2 2 RGILTLK 7 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q6S8J3;C9JUM1;C9JZR7;C9JTX5;A5A3E0;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;P0CG38;P0CG39 P60709;P63261;P68133;P0CG38 ACTB;POTEE;POTEF;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 ; 95.909 0.031777 8476600.0 81491.0 72086.0 78216.0 83228.0 91946.0 71922.0 62648.0 67714.0 53408.0 78885.0 False True 76962.05645431987 77614.76440697705 73183.6677151419 71892.20282369175 80394.92147233075 81828.60265708836 65561.25613465691 67911.03652934376 64091.0923442026 76607.38508215551 1.0046297282146364 1.0131498983256144 0.9553082595974013 0.9384500299363163 1.0494408781361406 1.0681555383901107 0.855808562899615 0.8864815899474237 0.8366176743334843 1.0 16.225195856658345 -7.272750160169152 24.998002774298513 0.885267084599569 1.0019887311010032 0.49417612405637834 0.05420076091739716 622.2006959200314 1375122.5856549724 0.022790302785704663 0.015524455841927545 5.3364179930600015e-08 7.272750160169152 0.11672164650143413 RGLAPNT(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 RGLAPNTPGK 10 1 O43663-3;O43663-2;O43663-4;O43663;G3V3N7;H0YL53 O43663-3 PRC1 Protein regulator of cytokinesis 1 1 RGLAPNT(1)PGK;RGLAPNT(1)PGK 102.73 0.018691 34237000.0 285050.0 306400.0 314470.0 344490.0 298820.0 246950.0 248040.0 267980.0 163562.0 292970.0 True False 269208.0621455601 329899.8947687175 294237.34256904764 297569.8677216039 261279.56011530533 280965.1209110978 259574.3514819356 268759.777433523 196278.9703041204 284511.19487252523 0.9462125462802204 1.1595322107326167 1.0341854657103395 1.045898625728698 0.9183454458878892 0.9875362585889942 0.9123519782700904 0.9446369150920066 0.6898813608795353 1.0 18.1181258948749 -6.739192599514411 0.8403857354168982 0.8700235715545277 1.0617644580626127 0.3512256416354873 0.09264608556388944 0.6329668877279491 0.9771842854603123 0.057442945246300475 0.055523658452135784 1.8230870262710725e-07 6.739192599514411 0.19174088650808496 RGLDDDRGPR ddPTM_A459_Selumetinib_30min_R2 2 RGLDDDRGPR 10 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 ; 108.57 0.010181 2793700.0 18050.2 16709.6 17795.699999999997 18958.8 20988.2 14072.6 12284.8 9967.4 11879.8 17796.8 False True 17047.042144675645 17991.172590167673 16650.744036493157 16376.5787342458 18351.474679111347 16010.972911656283 12856.067541869397 9996.403483808106 14256.091949345753 17282.960142360476 0.986349676459266 1.040977497024446 0.9634196861729861 0.9475563560496134 1.0618247411293824 0.9264022354835757 0.7438579639120512 0.5783964900380089 0.8248640181958252 1.0 14.077062716087895 -7.145363552574295 3.780589251718764 0.7518001742297021 0.997003791317142 0.4711157892131005 0.10372121338569276 0.18017353834333705 4.583535407662816 0.04022073034877374 0.030463284654746372 7.15544169724516e-08 7.145363552574295 0.24520361708743987 RGLLYDS(ph)DEEDEERPAR ddPTM_A459_Selumetinib_30min_R1 3 RGLLYDSDEEDEERPAR 17 2 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 RGLLYDS(1)DEEDEERPAR;RGLLYDS(1)DEEDEERPAR;RGLLYDS(1)DEEDEERPAR 157.85 4.4181e-05 184783000.0 2756.3900000000003 3114.47 3709.8 3891.2 3494.4700000000003 2661.0699999999997 2906.19 2829.32 1704.1799999999998 2174.4 True False 2820.60852399871 2749.826404522177 3206.0295364727417 3211.6749668704574 3178.3958054987875 2634.3020518582416 2686.973748513007 2754.277242673416 2891.868991617437 2453.505420449588 1.1496239219564686 1.1207745381782324 1.3067138591791896 1.3090148243006285 1.2954509001721985 1.0736891102427333 1.0951570459626854 1.1225886112649033 1.178668270921334 1.0 11.260628743370898 -6.769104433724705 24.99407113463987 1.1017534069807362 1.237846522352167 0.4910162349361652 0.07221487163826829 175.28021264281423 571547.061172385 0.027414229959797684 0.024633738884283 1.7017492437390476e-07 6.769104433724705 0.13609311537143087 RGLLYDS(ph)DEEDEERPAR ddPTM_A459_Selumetinib_30min_R2 2 RGLLYDSDEEDEERPAR 17 2 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 RGLLYDS(1)DEEDEERPAR;RGLLYDS(1)DEEDEERPAR 88.95100000000002 0.011075 137773000.0 65376.0 61564.0 84243.0 87653.0 86509.0 54097.0 72135.0 81766.0 61601.0 71302.0 True False 61742.663640863575 66285.76084053984 78822.8970968432 75714.51019014105 75640.96601972739 61548.37070632786 75489.42043279074 82003.92552290992 73922.92127574954 69243.32599515573 0.8916767465095928 0.9572873614588819 1.1383464899181426 1.0934557100194473 1.0923935979767818 0.8888708019403024 1.090205003122929 1.18428634593097 1.067581896353754 1.0 16.079387403524272 -5.066059671891886 4.762489672264115 1.0716041431609815 0.9041612606878332 0.38198914026163167 0.07567111835411745 0.20334382538430185 8.924086799058749 0.020446943798265015 0.06251032084994412 8.588955014917863e-06 5.066059671891886 -0.1674428824731483 RGLNSSFETS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 RGLNSSFETSPK 12 1 M0QZ79;M0QXD7;M0R025;M0QYG0;M0QYA8;Q8IV63-2;Q8IV63 M0QZ79 VRK3 Inactive serine/threonine-protein kinase VRK3 1 RGLNSSFET(0.241)S(0.759)PK;RGLNSSFET(0.315)S(0.685)PK 67.102 0.037632 10898300.0 86390.0 80943.0 73073.0 72789.0 66023.0 53778.0 69128.0 67275.0 40776.0 61384.0 True False 81588.78964657056 87151.0678272335 68371.56273586694 62875.01263197135 57728.60048689111 61185.431351921536 72342.58897453331 67470.7591120242 48932.33937663279 59611.68442521432 1.3686710991857234 1.4619796214040663 1.1469490150314794 1.0547430967304914 0.968410824883071 1.0263999741306011 1.2135639123784618 1.1318378227790133 0.8208514798473902 1.0 15.863307519131796 -5.406679537530896 3.2473624641967986 1.0428042302058904 1.416869235381106 0.6946743827216465 0.10011793402083909 0.1427326514900196 2.789873417521533 0.028140967525382976 0.06622274728525933 3.920310470207717e-06 5.406679537530896 0.3740650051752157 RGNDPLTS(ph)SPGR ddPTM_A459_Selumetinib_30min_R1 1 RGNDPLTSSPGR 12 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RGNDPLT(0.007)S(0.951)S(0.042)PGR 104.81 0.017218999999999998 360770000.0 4688.0 5772.7 6716.9 6637.3 6260.3 5591.0 5882.6 5171.4 2892.1 4973.9 True False 4797.221278739932 5096.829600344579 5804.781873290681 5478.220152551725 5694.056970345731 5534.75961622183 5438.87074589157 5034.237672925399 4907.682469373415 5612.348514888799 0.8547618284954248 0.9081455983753293 1.0342874926408048 0.9761012057641734 1.0145586923620602 0.9861753242049853 0.969089986386801 0.8969930608497048 0.8744436409025561 1.0 12.454388884690818 -10.568530259178898 14.46454278736332 0.9999999984701292 0.9508541369612976 0.06803868755366826 0.05747544920812168 0.0 0.0 0.060311601386548515 0.014627711830243764 2.7006589351559568e-11 10.568530259178898 -0.0491458615088316 RGNDPLTS(ph)SPGR ddPTM_A459_Selumetinib_30min_R2 1 RGNDPLTSSPGR 12 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RGNDPLT(0.093)S(0.614)S(0.294)PGR 116.87 0.0025179 96445000.0 13055.0 11136.0 12320.0 16516.0 13592.0 12000.0 13154.0 10053.0 11549.0 14084.0 True False 12329.455363305704 11990.095392116344 11527.344613001776 14266.49230831084 11884.451445978284 13652.89107484582 13765.687064156522 10082.252565636254 13859.122706021497 13677.358325373378 0.9014500512451202 0.8766382445265816 0.8428048998041507 1.0430736673648842 0.8689142423015265 0.9982111128519484 1.006458026227132 0.7371491135778969 1.0132894361852698 1.0 13.739501991432265 RGNDPLTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 6 RGNDPLTSSPGR 12 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RGNDPLT(0.005)S(0.009)S(0.985)PGR;RGNDPLTS(0.001)S(0.999)PGR;RGNDPLTSS(1)PGR;RGNDPLT(0.002)S(0.053)S(0.944)PGR;RGNDPLT(0.001)S(0.405)S(0.593)PGR;RGNDPLT(0.04)S(0.233)S(0.727)PGR 222.81 3.3367e-08 683776000.0 25655.3 29096.300000000003 32977.2 34713.299999999996 30545.0 25766.5 28550.100000000002 26385.9 15379.8 21534.200000000004 True False 26253.01857347621 25689.69166949712 28499.07737079328 28651.273804344204 27782.21014315775 25507.31240411016 26396.54297118262 25686.0602185177 26098.39730385161 24298.324330870844 1.080445639624702 1.0572618638092073 1.1728824170227001 1.1791460766676396 1.1433796736287964 1.0497560266616124 1.0863524007557182 1.0571124110761725 1.0740821856054406 1.0 14.568569205195386 -6.764355553019965 24.99965240033699 1.0590858594520844 1.1282576353380156 0.4418634758045763 0.040849117336350806 85.94890607533922 736815.5574910891 0.015327296161566454 0.014103148705390872 1.7204594734247842e-07 6.764355553019965 0.06917177588593115 RGNDPLTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 4 RGNDPLTSSPGR 12 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RGNDPLT(0.016)S(0.092)S(0.892)PGR;RGNDPLT(0.004)S(0.101)S(0.894)PGR;RGNDPLT(0.002)S(0.089)S(0.909)PGR;RGNDPLT(0.048)S(0.24)S(0.712)PGR 111.81 0.0034100000000000003 596898000.0 59439.2 56428.4 58169.2 66710.5 69420.6 57601.200000000004 51098.6 48855.6 47185.0 62486.8 True False 56135.80721797017 60756.27683409644 54426.657001836254 57624.41481796867 60699.36359996183 65535.242448367455 53474.786149955005 48997.76170752003 56623.3184590548 60682.643723795816 0.9250718784349425 1.0012134130252428 0.8969064902571744 0.9496029059025998 1.0002755297913868 1.079966831152888 0.8812204424275214 0.8074427661810369 0.933105662251343 1.0 15.888996319520116 RGPEVTSQGVQTS(ph)SPACK ddPTM_A459_Selumetinib_30min_R1 1 RGPEVTSQGVQTSSPACK 18 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB05;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 RGPEVTSQGVQTS(0.872)S(0.128)PACK 138.98 0.00059294 8599000.0 2448.7 3559.0 2295.2 2382.4 2207.5 2324.3 3286.9 2829.9 1445.3 2533.1 True False 2505.7499456592295 3142.310625465788 1983.5244466311492 1966.3585631867218 2007.8320147657805 2300.919652295547 3038.9664867016263 2754.8418591893087 2452.5685394645407 2858.2480594834688 0.8766733654713156 1.0993834545045238 0.6939651161661609 0.6879593801043546 0.7024694753500954 0.8050104834887425 1.0632269920095097 0.9638218243685794 0.858067070605397 1.0 11.480915414061785 -7.23693696550144 23.1307400739872 0.9682641126942698 0.8081891017498577 0.29076176486169436 0.12262199683769515 441.057694431939 416366.70276446786 0.05181886230155481 0.04011039337115213 5.79512802142172e-08 7.23693696550144 -0.16007501094441212 RGPEVTSQGVQTS(ph)SPACK ddPTM_A459_Selumetinib_30min_R2 1 RGPEVTSQGVQTSSPACK 18 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB05;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 RGPEVTSQGVQTS(0.5)S(0.5)PACK 194.1 4.8394e-10 9996900.0 20961.0 18172.0 20893.0 24986.0 24664.0 18903.0 22610.0 22813.0 15623.0 21245.0 True False 19796.071533531278 19565.733967810535 19548.767126578416 21582.863696745866 21565.487821042407 21506.71666565087 23661.409800865054 22879.382053104542 18748.036543092374 20631.601648860928 0.9595024114196302 0.9483381029165402 0.9475157314147593 1.046107038322808 1.0452648411924452 1.0424162424073489 1.1468527845569083 1.1089484201226671 0.9087048529810798 1.0 14.332568202769782 -5.774341919537066 7.176455771982725 1.0518218929294418 0.9511972447185815 0.31912984077328266 0.05975748732582851 0.15649783546101614 39.925244711999255 0.01701529730261553 0.026631506236516684 1.6813498151095608e-06 5.774341919537066 -0.10062464821086037 RGPEVTSQGVQTS(ph)SPACKQEK ddPTM_A459_Selumetinib_30min_R2 1 RGPEVTSQGVQTSSPACKQEK 21 2 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB05;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 RGPEVTSQGVQT(0.077)S(0.462)S(0.462)PACKQEK 43.534 0.042701 6164400.0 29286.0 43272.0 29237.0 39328.0 43235.0 20737.0 17459.0 18105.0 14065.0 35100.0 True False 27658.401361146738 46590.82325859001 27355.923250838714 33971.4585554159 37803.43277419595 23593.333518256488 18270.878094352178 18157.6825525559 16878.393008935163 34086.571799247766 0.8114163408406214 1.3668380479264914 0.8025425206134227 0.9966229151904795 1.1090417950164824 0.692159178024971 0.5360139530005592 0.5326931279418545 0.49516252641480485 1.0 15.056915889648419 -6.86380054997801 4.901797454551159 0.6042107432526213 1.022852024700288 0.45201281161284845 0.1999496687605433 0.17240294826923963 6.796208405189604 0.06816516476396381 0.06025126697518765 1.3683571002012315e-07 6.86380054997801 0.41864128144766666 RGPEVTSQGVQTSS(ph)PACK ddPTM_A459_Selumetinib_30min_R1 3 RGPEVTSQGVQTSSPACK 18 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB05;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 RGPEVTSQGVQT(0.001)S(0.344)S(0.655)PACK;RGPEVTSQGVQT(0.004)S(0.046)S(0.951)PACK;RGPEVTSQGVQT(0.02)S(0.261)S(0.719)PACK 119.18 0.0005036000000000001 22910600.0 9976.1 12902.5 9745.0 9981.6 10764.1 9822.099999999999 12120.6 11552.2 5673.4 10644.8 True False 10208.523719888533 11391.869301790479 8421.682525453361 8238.500937837724 9790.489055556203 9723.298591753257 11206.33338364896 11245.798129165956 9627.34543125865 12011.16376913253 0.849919617791192 0.9484400946281679 0.7011545831300902 0.6859036389970665 0.8151157742696644 0.8095217731308556 0.9329931386372482 0.9362788107232801 0.801533108390375 1.0 13.552088320985643 -7.213959423814609 6.106982090803381 0.9123648678552913 0.7985440261906882 0.319158316507403 0.08283131982976587 0.2938271249404927 27.588815250476024 0.03438267866751145 0.02621698256008221 6.109991079586313e-08 7.213959423814609 -0.11382084166460305 RGPEVTSQGVQTSS(ph)PACK ddPTM_A459_Selumetinib_30min_R2 3 RGPEVTSQGVQTSSPACK 18 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4;F8W0B5;F8WB05;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 RGPEVTSQGVQTS(0.154)S(0.846)PACK;RGPEVTSQGVQT(0.001)S(0.063)S(0.935)PACK;RGPEVTSQGVQTS(0.037)S(0.963)PACK 135.31 0.00018519 93729000.0 321745.0 282245.0 332530.0 362740.0 352830.0 310771.0 319663.0 349982.0 302025.0 328343.0 True False 303863.70094728394 303892.28393928474 311135.3818312888 313334.1862385975 308504.3410597793 353576.88435174245 334527.9629002178 351000.38967736094 362438.43928358663 318862.8844524327 0.9529603969715507 0.9530500373574171 0.9757654371269521 0.9826612049146788 0.9675141137531839 1.1088681110030174 1.049127945620532 1.1007878520578411 1.1366592255037273 1.0 18.28257665251401 -6.753612776400899 24.9975555382364 1.083515327125805 0.9670738792308842 0.7146656093440628 0.035548901139516524 90.64272218825975 289505.1145941387 0.011444409834403734 0.011247133331230829 1.7635477517639797e-07 6.753612776400899 -0.11644144789492072 RGPGLYYVDSEGNR ddPTM_A459_Selumetinib_30min_R1 2 RGPGLYYVDSEGNR 14 1 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 ; 141.65 0.00074766 10282600.0 3109.7 3980.0 3623.3 4054.8999999999996 4119.9 3495.4 3663.5 3327.7 1877.6799999999998 3173.7 False True 3182.1499595771243 3514.0197497481986 3131.2757613622516 3346.7878349000343 3747.255772427422 3460.239449569269 3387.15924549923 3239.4385861070214 3186.285819678806 3581.0753094558772 0.8886017982293237 0.9812750210724087 0.8743953954540068 0.9345762224164335 1.0464051852058913 0.9662571017237365 0.9458497665646379 0.904599402741752 0.8897567195153299 1.0 11.806177143291507 -4.737035687358327 24.071280158872952 0.9469196054739968 0.8886013859389765 0.11643998209178208 0.04974032957727764 3539.0224875475533 3490524.505612647 0.01297659777703131 0.785006218405102 1.8321638614557807e-05 4.737035687358327 -0.058318219535020255 RGPGLYYVDSEGNR ddPTM_A459_Selumetinib_30min_R2 2 RGPGLYYVDSEGNR 14 1 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 ; 206.45 1.0244e-05 12585600.0 30616.0 34716.0 40806.0 40683.0 38804.0 26766.0 29893.0 28356.0 31272.0 33975.0 False True 28914.485285558603 37378.60557046614 38180.58638621352 35141.90521791052 33929.09460783854 30452.77354244361 31283.08373185576 28438.511265411507 37527.27381268543 32994.05347234878 0.8763544409537577 1.1328891614300107 1.1571959904293483 1.0650981470755567 1.0283396866127221 0.922977638014834 0.9481430876043488 0.8619283862543557 1.1373950716342203 1.0 15.009918410111249 -6.551203195003187 4.454789038858533 0.9639909634915764 1.0684538167404356 0.13761223497487807 0.09631280080356348 0.3339130410198388 15.703676907807878 0.03191049038652815 0.032892830821372586 2.8105855234363247e-07 6.551203195003187 0.10446285324885918 RGPLSQNGSFGPSPVSGGECS(ph)PPLTVEPPVRPLSATLNR ddPTM_A459_Selumetinib_30min_R1 1 RGPLSQNGSFGPSPVSGGECSPPLTVEPPVRPLSATLNR 39 2 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 RGPLSQNGSFGPSPVS(0.02)GGECS(0.869)PPLT(0.075)VEPPVRPLS(0.026)AT(0.01)LNR 66.00399999999999 4.6796e-06 27514000.0 1339.1 1177.1 1182.0 1610.2 1459.0 1441.3 1062.4 1191.0 716.75 1175.1 True False 1370.2984245649827 1039.2845847810565 1021.4908922612483 1329.008797197474 1327.0337076073715 1426.8018305956946 982.2623126568526 1159.4108110867755 1216.2724006512212 1325.9355314432992 1.0334578055038572 0.7838123046976355 0.7703925779478443 1.002317809336348 1.0008282274198332 1.0760717974293976 0.7408069920169094 0.8744096402822397 0.9172937686701041 1.0 10.372794916275408 -5.770144862584872 24.999219320976838 0.9386375470502244 0.8546800287445532 0.1036123377145185 0.10880359385840166 446.6510191690995 1282633.0007028503 0.0322046512286529 0.04861317129796299 1.6976772834417198e-06 5.770144862584872 -0.08395751830567122 RGPNYTSGYGTNSELS(ph)NPS(ph)ETESER ddPTM_A459_Selumetinib_30min_R2 1 RGPNYTSGYGTNSELSNPSETESER 25 1 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 2 RGPNYTSGYGTNS(0.054)ELS(0.936)NPS(0.932)ET(0.072)ES(0.005)ER 97.913 1.3994e-05 9036200.0 19776.0 14464.0 14435.0 16392.0 21022.0 10399.0 18425.0 16905.0 12270.0 15113.0 True False 18676.929089600428 15573.342290909728 13506.267815639661 14159.381322222769 18381.02842093552 11831.367857276811 19281.79900844486 16954.19075122659 14724.342852444686 14676.648421710299 1.2725609112481533 1.0610966375588178 0.9202555942990798 0.9647557749818162 1.2523995869346813 0.8061355370327852 1.3137739935176505 1.1551813645782547 1.0032496813553042 1.0 13.841234929649243 RGPNYTSGYGTNSELS(ph)NPSETESER ddPTM_A459_Selumetinib_30min_R2 2 RGPNYTSGYGTNSELSNPSETESER 25 1 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 RGPNYTSGYGT(0.001)NS(0.002)ELS(0.885)NPS(0.093)ET(0.012)ES(0.006)ER;RGPNYTSGYGTNS(0.001)ELS(0.82)NPS(0.176)ET(0.003)ESER 125.15 3.8786e-08 123543000.0 39622.0 48105.0 61574.0 71040.0 59046.0 42489.0 39073.0 40484.0 36882.0 52882.0 True False 37419.967859433054 51794.498818045664 57612.39587670222 61364.22944916462 51628.11360206252 48341.47407326034 40889.971921680655 40601.801737513 44259.43056918219 51355.15925606323 0.7286506049538748 1.0085549255098565 1.1218424148864894 1.194899019652435 1.0053150326073046 0.941316798030432 0.7962193577824996 0.7906080387185123 0.8618302661374128 1.0 15.64822159979774 -6.96715034455423 3.158736977926074 0.8456590258696411 1.0276302065346152 0.23076507151484904 0.12531079069143805 0.3355755457320666 6.902887299809368 0.05138651806636414 0.042662926107618356 1.0785732758787532e-07 6.96715034455423 0.18197118066497409 RGPNYTSGYGTNSELSNPS(ph)ETESER ddPTM_A459_Selumetinib_30min_R1 4 RGPNYTSGYGTNSELSNPSETESER 25 1 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 RGPNYTSGYGTNSELSNPS(0.93)ET(0.068)ES(0.002)ER;RGPNYTSGYGTNSELSNPS(0.918)ET(0.072)ES(0.01)ER;RGPNYTSGYGTNSELSNPS(0.94)ET(0.054)ES(0.006)ER;RGPNYTSGYGTNSELS(0.001)NPS(0.8)ET(0.176)ES(0.023)ER 173.83 4.844100000000001e-17 124177000.0 5458.95 6865.5 6864.6 6020.3 6407.2 5976.9 6885.0 7031.199999999999 3368.98 5905.6 True False 5586.13291373237 6061.6840683156415 5932.425024548704 4968.9676200272925 5827.669891283036 5916.777812590994 6365.658906854701 6844.709735443609 5716.912999436275 6663.641285415326 0.8383003637903961 0.9096654229546862 0.8902677635924023 0.7456835395540939 0.8745473595702135 0.8879196161925781 0.9552823500249304 1.027172598624807 0.8579262830291976 1.0 12.702095024849115 -7.101663952735436 2.5156823607931096 0.963152653614031 0.851709410874538 0.4413866490686481 0.05769265632558642 0.28743282659006825 3.5593310442200985 0.025166003099452924 0.018758244541245663 7.91290674033335e-08 7.101663952735436 -0.11144324273949302 RGPNYTSGYGTNSELSNPS(ph)ETESER ddPTM_A459_Selumetinib_30min_R2 2 RGPNYTSGYGTNSELSNPSETESER 25 1 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 RGPNYTSGYGTNSELS(0.041)NPS(0.873)ET(0.078)ES(0.008)ER;RGPNYTSGYGTNSELS(0.001)NPS(0.927)ET(0.07)ES(0.002)ER 154.25 5.3059e-11 27588000.0 16648.0 15219.0 14933.8 20527.7 21735.8 20540.8 16644.1 16259.9 14949.1 18443.2 True False 15722.77080722431 16386.2483632021 13972.975566692045 17731.791847742345 19005.15448348255 23370.10874918275 17418.083629658464 16307.21361702864 17939.33771275313 17910.69689481156 0.8778424926491242 0.9148861409155403 0.7801469506605179 0.9900112738147535 1.0611063653803463 1.3048129219334113 0.9724961419398594 0.9104734289681702 1.0015990900917913 1.0 14.128533852391387 -5.939579062847626 5.7967159779849915 1.0453139309207429 0.8642616972037295 0.3915532872107529 0.10245983512470493 0.22530849958223367 15.074148503705494 0.03185327403043344 0.04753626582842871 1.1492670015413644e-06 5.939579062847626 -0.1810522337170134 RGPNYTSGYGTNSELSNPS(ph)ETESERK ddPTM_A459_Selumetinib_30min_R1 1 RGPNYTSGYGTNSELSNPSETESERK 26 2 B4DXZ6;P51114-3;P51114;E7EU85;E9PFF5;P51114-2 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 RGPNYTSGYGTNSELS(0.001)NPS(0.87)ET(0.068)ES(0.058)ERK 49.967 0.039176 10806000.0 409.42 465.71 543.58 507.65 254.36 482.61 534.47 412.45 262.75 502.74 True False 418.95868940735966 411.1844566972948 469.76482167120935 418.99845727071 231.35318291090545 477.7553815748202 494.15449759573465 401.5104861735857 445.86755949927874 567.271576102293 0.7385504704572243 0.7248458657536336 0.828112744338347 0.7386205742047514 0.4078349641639488 0.8421986958300712 0.8711074526086011 0.7077923574672169 0.7859860748934789 1.0 9.147895767438406 -9.49978058901863 0.5050940480101973 1.0257292341603814 0.7177174534803851 0.3129956767420762 0.12031627172304943 5.414259628955246 1.7374068215670773 0.4152865439612866 0.0633477727792597 3.1638756858655287e-10 9.49978058901863 -0.30801178067999635 RGQS(ph)PLPR ddPTM_A459_Selumetinib_30min_R1 1 RGQSPLPR 8 1 H3BTS1;H3BN52;Q9BQ65-3;Q9BQ65-2;Q9BQ65 H3BTS1 USB1 U6 snRNA phosphodiesterase 1 RGQS(1)PLPR 82.417 0.021237 5611200.0 779.49 1249.6 1409.6 1303.1 1247.6 1310.6 1245.6 1106.6 620.34 892.99 True False 797.6506003764905 1103.29625107672 1218.1840623785583 1075.5380472165125 1134.7548002816702 1297.4165539295889 1151.6433891616864 1077.2493732566127 1052.6716721590215 1007.6139649591969 0.7916232090022602 1.094959269566493 1.208978939099845 1.067410818646272 1.1261801044288047 1.287612715830241 1.142941075859664 1.069109213169982 1.0447172317641005 1.0 9.976727306922072 -4.766658050261397 4.639707956524429 1.1277587633279615 0.7670309405597908 0.6005241683677429 0.07920138787447589 0.12814029654196082 6.39706812953085 0.020192678972301644 0.1525945983663122 1.7113622572629792e-05 4.766658050261397 -0.3607278227681707 RGQS(ph)PLPR ddPTM_A459_Selumetinib_30min_R2 3 RGQSPLPR 8 1 H3BTS1;H3BN52;Q9BQ65-3;Q9BQ65-2;Q9BQ65 H3BTS1 USB1 U6 snRNA phosphodiesterase 1 RGQS(1)PLPR;RGQS(1)PLPR;RGQS(1)PLPR 75.566 0.029731 44130100.0 17699.8 18042.5 23460.0 21544.1 19680.4 15737.2 20094.8 20138.100000000002 14861.8 17544.2 True False 16716.11597391331 19426.30173421866 21950.609141316698 18609.756414354546 17207.97220699169 17904.856451921973 21029.248017090795 20196.698536958076 17834.575273387316 17037.653360694076 0.9811278360949311 1.140198202355449 1.2883587121191717 1.0922722760217272 1.0099966141282426 1.0508992097015273 1.234280776342436 1.1854155093653875 1.0467741593177229 1.0 14.056439022740875 RGQS(ph)SPPPAPPICLR ddPTM_A459_Selumetinib_30min_R1 4 RGQSSPPPAPPICLR 15 1 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 RGQS(0.771)S(0.229)PPPAPPICLR;RGQS(0.889)S(0.111)PPPAPPICLR;RGQS(0.764)S(0.236)PPPAPPICLR;RGQS(0.789)S(0.211)PPPAPPICLR 170.35 9.5476e-05 58263300.0 8856.3 10058.7 12705.0 13891.5 11723.6 9815.4 10477.9 9769.2 5850.3 7875.4 True False 9062.634558640026 8881.022727837235 10979.730783569521 11465.610300750657 10663.202449969698 9716.665987670143 9687.543567194318 9510.08908116619 9927.531810993838 8886.284302892143 1.0198452187367544 0.9994078993113921 1.2355817582829351 1.2902592253343776 1.1999618835624284 1.0934453205045154 1.090168087919649 1.070198606865529 1.117174678708266 1.0 13.11736458353997 -6.920449367539253 7.12566422295245 1.077526109438359 1.1532239655487575 0.15469579200798445 0.0877504096400687 0.5185572006459725 38.79722328118072 0.0351652468724877 0.03098538557953178 1.2010210865558777e-07 6.920449367539253 0.07569785611039848 RGQS(ph)SPPPAPPICLR ddPTM_A459_Selumetinib_30min_R2 2 RGQSSPPPAPPICLR 15 1 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 RGQS(0.785)S(0.215)PPPAPPICLR;RGQS(0.785)S(0.215)PPPAPPICLR 194.01 5.7231e-05 19295100.0 38936.0 41230.0 42334.0 43369.0 46043.0 31587.5 33734.0 34774.0 28273.0 41893.0 True False 36772.092993157494 44392.20842465488 39610.27652977413 37462.067384302085 40258.66671035746 35938.391402224355 35302.69784265289 34875.18658285442 33928.390013624194 40683.44023891414 0.903858984815758 1.091161616715817 0.9736216086241025 0.9208185729698745 0.9895590558206928 0.8833665784204972 0.8677412144926103 0.8572329768094669 0.8339606929595725 1.0 15.31215405986992 -6.767844288834784 21.219074541013974 0.8782422324627747 0.9790367673810518 0.32106320909718855 0.06254343331780389 24.596867995661718 81484.89217474472 0.021173683174177907 0.01920617670952192 1.7066941943965538e-07 6.767844288834784 0.10079453491827717 RGRS(ph)PQPPAEEDEDDFDDTLVAIDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R1 1 RGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFK 33 2 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-3;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;M0R0K8;M0QYI8;M0QYZ0 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 RGRS(0.829)PQPPAEEDEDDFDDT(0.171)LVAIDTYNCDLHFK 59.536 0.00028766 4608400.0 591.91 528.18 738.16 741.29 409.37 647.35 528.71 389.54 172.17 240.72 True False 605.7003513436331 466.3404400557794 637.9219264226422 611.8376172366882 372.34255578014364 640.8382467467723 488.8289790331369 379.208133795754 292.1599152007261 271.6187568113617 2.2299651115931214 1.7168933601284806 2.3485930570902243 2.252560259163572 1.370827847646524 2.359329872022911 1.7996878594530454 1.3961043716105097 1.0756249628357961 1.0 8.085439299049481 -7.870103859865432 1.9149987851374433 1.028718960140168 2.0302369634002413 0.6616220804573946 0.29097600626747394 0.2151940303335719 1.4927966311288094 0.2247596029274548 0.08306198595380969 1.3486403218452707e-08 7.870103859865432 1.0015180032600732 RGS(ph)ASGSEPAGDSDR ddPTM_A459_Selumetinib_30min_R1 1 RGSASGSEPAGDSDR 15 1 A0A0C4DG27;P50747 A0A0C4DG27 HLCS Biotin--protein ligase;Biotin--[methylmalonyl-CoA-carboxytransferase] ligase;Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase;Biotin--[methylcrotonoyl-CoA-carboxylase] ligase;Biotin--[acetyl-CoA-carboxylase] ligase 1 RGS(0.998)AS(0.001)GSEPAGDSDR 132.5 0.00031759 1208300.0 313.82 353.73 335.34 276.62 305.45 299.58 390.42 310.48 309.61 191.96 True False 321.131395412578 312.3151271553844 289.80266989076745 228.31350980050001 277.8221014315774 296.56649719687647 360.9703050710548 302.24506181882646 525.3855569802921 216.59993584874127 1.4826015259618286 1.441898521029499 1.337962861139285 1.0540793048061599 1.282650894345553 1.3691901432693796 1.6665300645478123 1.395406977543585 2.4256034745420507 1.0 7.758889005432338 -8.049551900348703 24.999107322963894 1.7787031196071883 1.3733012471675825 0.12070304447327829 0.3519772338945497 620.2937068585256 312936.5211184739 0.22246894336552692 0.08408838215589462 8.921709943495895e-09 8.049551900348703 -0.4054018724396058 RGS(ph)ASGSEPAGDSDR ddPTM_A459_Selumetinib_30min_R2 3 RGSASGSEPAGDSDR 15 1 A0A0C4DG27;P50747 A0A0C4DG27 HLCS Biotin--protein ligase;Biotin--[methylmalonyl-CoA-carboxytransferase] ligase;Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase;Biotin--[methylcrotonoyl-CoA-carboxylase] ligase;Biotin--[acetyl-CoA-carboxylase] ligase 1 RGS(0.965)AS(0.035)GSEPAGDSDR;RGS(0.994)AS(0.005)GSEPAGDSDR;RGS(0.996)AS(0.003)GSEPAGDSDR 184.92 3.8107e-05 42916800.0 18864.9 14558.7 16450.399999999998 18580.0 19067.7 10366.599999999999 15223.5 16035.5 16494.699999999997 23840.199999999997 True False 17816.464380178153 15675.305476401234 15391.999173841265 16049.371947712245 16672.245058599205 11794.505051374723 15931.422914792975 16082.160650180069 19794.100900425372 23151.871481721537 0.7695474810424849 0.6770642921362504 0.6648274281408865 0.6932213648638844 0.7201251558329522 0.5094406757002999 0.6881267860946306 0.6946376090104412 0.8549676390547031 1.0 14.498841198014205 -8.45490643901405 2.0804206589425887 0.9987409660739783 0.6705422488518424 0.7388182646144279 0.06262352839310101 0.1529441803381916 1.442454296963766 0.060856909039696615 0.01703802221669267 3.508274453163715e-09 8.45490643901405 -0.3281987172221359 RGS(ph)DASDFDLLETQSACSDTSESSAAGGQGNSR ddPTM_A459_Selumetinib_30min_R1 1 RGSDASDFDLLETQSACSDTSESSAAGGQGNSR 33 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 RGS(0.628)DAS(0.217)DFDLLET(0.108)QS(0.042)ACS(0.004)DTSESSAAGGQGNSR 71.081 3.8427e-05 10680000.0 527.35 322.28 765.34 644.04 520.59 389.88 462.86 457.62 313.36 444.11 True False 539.636228955525 284.5473077760929 661.4110317116953 531.5705041280961 473.50272641762945 385.9581611827166 427.9460975492759 445.48243104074754 531.7490330911287 501.11584449773113 1.0768692207216135 0.5678274013891836 1.3198765095416773 1.0607736912826808 0.9448967371850349 0.7701974811224794 0.8539863631296805 0.8889809331158846 1.0611299541408459 1.0 8.969000344019802 -6.520308413698992 24.69298398325173 0.898941439699099 0.998088436110568 0.04622687686947535 0.1881544843325728 301.48588549018405 2896397.723011162 0.062238277636391275 0.06334090790978349 3.0178078666723325e-07 6.520308413698992 0.09914699641146896 RGS(ph)DASDFDLLETQSACSDTSESSAAGGQGNSR ddPTM_A459_Selumetinib_30min_R2 4 RGSDASDFDLLETQSACSDTSESSAAGGQGNSR 33 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 RGS(0.725)DAS(0.272)DFDLLET(0.003)QSACSDTSESSAAGGQGNSR;RGS(0.956)DAS(0.044)DFDLLETQSACSDTSESSAAGGQGNSR;RGS(0.806)DAS(0.177)DFDLLET(0.016)QS(0.001)ACSDTSESSAAGGQGNSR;RGS(0.692)DAS(0.285)DFDLLET(0.009)QS(0.014)ACSDTSESSAAGGQGNSR 112.04 1.4655000000000005e-14 52727000.0 76378.0 65052.0 79214.0 95033.0 90549.0 53606.0 64481.9 68485.0 58539.0 76331.0 True False 72133.21652535906 70041.27922485191 74117.45748168204 82089.34145893119 79173.42510166927 60989.73991318209 67480.43611846089 68684.28001169792 70248.43571632105 74127.12569824458 0.9731014907956598 0.9448805489905914 0.9998695724881888 1.1074129839203406 1.0680762859195039 0.822772221891593 0.9103339092515077 0.9265741705849583 0.947675160133514 1.0 16.17771395108457 -6.745537016405141 24.9988883224532 0.9161858791452804 1.0184547604190703 0.4009654797105219 0.059225032918091204 260.0366097846528 408782.94413987815 0.02109892840139515 0.021032263464787676 1.7966479391940247e-07 6.745537016405141 0.10226888127378997 RGS(ph)DELTVPR ddPTM_A459_Selumetinib_30min_R2 2 RGSDELTVPR 10 1 A0A087WVV7;A0A590UJ70;A0A087X165;Q9C0H9-2;Q9C0H9 A0A087WVV7 SRCIN1 SRC kinase signaling inhibitor 1 1 RGS(1)DELTVPR;RGS(1)DELTVPR 95.273 0.011778 3539300.0 13247.8 13407.400000000001 14318.7 16285.0 15669.0 11189.2 11772.6 15455.9 12426.2 15472.8 True False 12511.54031114526 14435.704468414198 13397.450431021794 14066.954906808074 13700.520137362693 12730.41073455541 12320.049226964355 15500.874110138004 14911.787217037352 15026.060060837615 0.8326560828645998 0.9607112183743988 0.8916143271608196 0.936170549688587 0.9117839328401413 0.8472221382726034 0.8199121510950212 1.0315993711843263 0.9923950228245065 1.0 13.875179153551866 -7.776263917074438 24.999999999832045 1.0089979417390786 0.8902966642487826 0.6278018697630806 0.0430410951874723 170.61452691542618 287718.954105696 0.02422439124934749 0.011712613522118293 1.6739253366482086e-08 7.776263917074438 -0.11870127749029602 RGS(ph)EDFETR ddPTM_A459_Selumetinib_30min_R2 1 RGSEDFETR 9 1 A2AJT9-3;A2AJT9-2;A2AJT9 A2AJT9-3 CXorf23 Uncharacterized protein CXorf23 1 RGS(0.995)EDFET(0.005)R 103.43 0.027379 4576400.0 21838.0 18380.0 21725.0 27449.0 22954.0 14576.0 20840.0 23124.0 19118.0 24249.0 True False 20624.331384440444 19789.68689898512 20327.23715239154 23710.398847833865 20070.31330863639 16583.711692246063 21809.101293676595 23191.287011615725 22942.134201551544 23548.868363531583 0.8758098718824147 0.8403667893286952 0.8631937993194972 1.0068593735294913 0.8522835576981619 0.7042254190833241 0.9261209904867769 0.9848153488143991 0.9742351032493924 1.0 14.523370112612657 -7.51816668666631 22.002115415820477 0.9788089896597331 0.8592194480768768 0.41825710354069134 0.06857209292133705 48.73711855950073 227588.07207769857 0.03363072238256357 0.020177117229698182 3.032726969144941e-08 7.51816668666631 -0.11958954158285628 RGS(ph)FDATGSGFSMTFSSSSYSSSGYGR ddPTM_A459_Selumetinib_30min_R1 6 RGSFDATGSGFSMTFSSSSYSSSGYGR 27 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 RGS(0.853)FDAT(0.036)GS(0.102)GFS(0.009)MTFSSSSYSSSGYGR;RGS(0.882)FDAT(0.084)GS(0.034)GFS(0.001)MTFSSSSYSSSGYGR;RGS(0.97)FDAT(0.026)GS(0.004)GFSMTFSSSSYSSSGYGR;RGS(0.931)FDAT(0.01)GS(0.059)GFSMTFSSSSYSSSGYGR;RGS(0.768)FDAT(0.116)GS(0.116)GFS(0.001)MTFSSSSYSSSGYGR;RGS(0.957)FDAT(0.01)GS(0.033)GFSMTFSSSSYSSSGYGR 133.31 2.7365e-12 138336000.0 3109.75 4191.28 4248.78 3885.5699999999997 4212.8 3867.37 3415.64 4105.409999999999 2021.1499999999996 2904.09 True False 3182.201124479841 3700.562989126789 3671.819012877962 3207.0281406822664 3831.75298383025 3828.4677690910066 3157.99552485246 3996.521190548916 3429.743931044596 3276.858239732086 0.9711134543128773 1.1293021297831134 1.120530320279637 0.978689923719273 1.1693374273473398 1.1683348771913977 0.9637266228247505 1.2196197998713758 1.0466561810513384 1.0 11.678097546416957 -4.751107544666416 24.82483433244394 1.0940259621186434 0.971113175717806 0.14705057356228846 0.08383283114235891 730.8826431562461 1755999.2491572201 0.019702850282356184 0.26727709539544764 1.773750191418997e-05 4.751107544666416 -0.12291278640083747 RGS(ph)FDATGSGFSMTFSSSSYSSSGYGR ddPTM_A459_Selumetinib_30min_R2 2 RGSFDATGSGFSMTFSSSSYSSSGYGR 27 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 RGS(0.397)FDAT(0.148)GS(0.388)GFS(0.059)MT(0.008)FSSSSYSSSGYGR;RGS(0.963)FDAT(0.016)GS(0.02)GFS(0.001)MTFSSSSYSSSGYGR 74.44 0.00010837 15851300.0 4505.700000000001 4309.9 5607.0 4319.1 5653.0 4075.5 6326.7 6709.700000000001 3991.9 4992.6 True False 4255.291231746191 4640.455471487268 5246.251724440014 3730.8311291369205 4942.819601538793 4636.86313129451 6620.904086118217 6729.224116149373 4790.391543005214 4848.450665667363 0.8776600042315732 0.9571006887513693 1.0820470468204497 0.7694893454429719 1.0194637302467924 0.9563597633629363 1.365571095319557 1.387912259023292 0.9880252215262755 1.0 12.243308088857754 -7.2258297091150885 16.244980865074577 1.2176997814491475 0.9461061160449179 0.3919551898468907 0.14524030728983864 8.714127699607646 3974.8487544178975 0.05438040113796313 0.0420958080315626 5.945252317620752e-08 7.2258297091150885 -0.2715936654042296 RGS(ph)FSSENYWR ddPTM_A459_Selumetinib_30min_R1 4 RGSFSSENYWR 11 1 Q6P6C2-3;Q6P6C2;Q6P6C2-1;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 RGS(0.983)FS(0.017)SENYWR;RGS(0.997)FSS(0.002)ENYWR;RGS(0.925)FS(0.008)S(0.067)ENYWR;RGS(0.455)FS(0.09)S(0.455)ENYWR 138.89 0.0016803 191596900.0 6352.970000000001 6534.47 8069.29 8654.92 6565.03 6733.370000000001 6690.030000000001 6163.32 4417.96 5754.5599999999995 True False 6500.981840272278 5769.411214607313 6973.524739437202 7143.500694969788 5971.224195650184 6665.6384112108035 6185.395650925948 5999.848732315155 7496.955444968354 6493.213830161136 1.001196327475781 0.8885293732062631 1.073971213922605 1.1001486908975728 0.9196099730943255 1.026554582300794 0.9525938637958656 0.9240183504269814 1.1545831757680325 1.0 12.664717004674564 -8.256010378462413 24.99408329098624 1.0772915865642365 0.9873758291881667 0.1999582617929938 0.0731281305946688 676.0269650986585 3112340.759064685 0.05265733742011104 0.018594130170294702 5.546124590631978e-09 8.256010378462413 -0.08991575737606983 RGS(ph)FSSENYWR ddPTM_A459_Selumetinib_30min_R2 5 RGSFSSENYWR 11 1 Q6P6C2-3;Q6P6C2;Q6P6C2-1;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 RGS(0.954)FS(0.045)S(0.001)ENYWR;RGS(0.992)FS(0.007)S(0.001)ENYWR;RGS(0.981)FS(0.018)SENYWR;RGS(0.975)FS(0.024)S(0.001)ENYWR;RGS(0.971)FS(0.028)S(0.001)ENYWR 130.19 0.0012537000000000002 126612400.0 27477.899999999998 27348.2 34313.4 32141.5 35128.2 30160.5 23210.1 26910.200000000004 19892.199999999997 29674.9 True False 25950.78832074897 29445.719001677102 32105.71320160513 27763.772252819883 30715.081465907504 34314.835105240614 24289.415639940635 26988.504226776557 23871.195834506947 28818.10853235033 0.9005028311145892 1.0217783366532276 1.1140812092356525 0.963414105462651 1.0658257266061613 1.190738631118688 0.842852528391101 0.9365119919817113 0.8283401323063889 1.0 14.814688027326213 -7.28825638527125 24.999719147520025 0.896635489389591 1.0424601126479 0.38974002932315566 0.08620972891587375 787.0675729900722 733727.6998947349 0.03584768746131416 0.024175667308408054 5.149245696802753e-08 7.28825638527125 0.14582462325830903 RGS(ph)GDTSISIDTEASIR ddPTM_A459_Selumetinib_30min_R1 4 RGSGDTSISIDTEASIR 17 1 Q32MZ4-2;Q32MZ4;Q32MZ4-3;Q32MZ4-4 Q32MZ4-2;Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 RGS(0.986)GDT(0.014)SISIDTEASIR;RGS(0.995)GDT(0.003)S(0.001)ISIDTEASIR;RGS(0.996)GDT(0.003)S(0.001)ISIDTEASIR;RGS(0.993)GDT(0.004)S(0.001)IS(0.001)IDTEASIR 189.84 1.3111e-07 27741700.0 6284.73 6960.800000000001 7909.549999999999 7219.29 6979.360000000001 5826.86 6213.67 6369.950000000001 3860.09 5674.58 True False 6431.151981044201 6145.826300011871 6835.476554048188 5958.576524357068 6348.078120306093 5768.247078765576 5744.967869245586 6200.998233486319 6550.29080018105 6402.967618089968 1.0044017656554447 0.9598402907190083 1.0675481997966498 0.930596073533562 0.9914274909607854 0.9008708809441501 0.8972351902912379 0.9684569098814375 1.0230085783465246 1.0 12.644524998461279 -5.795262829385585 24.999679423439183 0.9538656591845532 1.0055213402134144 0.20394557499540855 0.04585325392904581 286.9819913072429 212113.72923758772 0.013228405517748813 0.019621956647378553 1.6022754209174702e-06 5.795262829385585 0.0516556810288612 RGS(ph)GDTSISIDTEASIR ddPTM_A459_Selumetinib_30min_R2 1 RGSGDTSISIDTEASIR 17 1 Q32MZ4-2;Q32MZ4;Q32MZ4-3;Q32MZ4-4 Q32MZ4-2;Q32MZ4-4 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 RGS(0.998)GDT(0.001)SISIDTEASIR 77.66 0.045862 0.0 5133.6 5457.2 7705.3 7526.8 6711.3 4038.7 4332.2 5515.8 6709.3 5673.4 True False 4848.295063429041 5875.74969233632 7209.549386896311 6501.636855545777 5868.166494216751 4594.994265331648 4533.655884091444 5531.850064810153 8051.347473505061 5509.594200736531 0.8799731680385668 1.0664577967558555 1.3085445359900603 1.180057299805606 1.065081434388087 0.8339986753865435 0.8228656628623171 1.0040394742811813 1.4613322107150368 1.0 12.427730348259898 -6.5242932922577435 24.990059150539704 1.0051496375488065 1.1203274804304284 0.03494166664300169 0.19243592185385489 147.69691621710382 2609213.372444113 0.0670160617075581 0.06752241790933991 2.9902445515815503e-07 6.5242932922577435 0.11517784288162192 RGS(ph)GDTSSLIDPDTSLSELR ddPTM_A459_Selumetinib_30min_R1 6 RGSGDTSSLIDPDTSLSELR 20 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 RGS(0.998)GDT(0.002)SSLIDPDTSLSELR;RGS(1)GDTSSLIDPDTSLSELR;RGS(0.962)GDT(0.03)S(0.008)SLIDPDTSLSELR;RGS(0.8)GDT(0.099)S(0.046)S(0.055)LIDPDTSLSELR;RGS(0.998)GDT(0.001)S(0.001)SLIDPDTSLSELR;RGS(0.558)GDT(0.329)S(0.089)S(0.024)LIDPDTSLSELR 183.1 6.1542e-14 853928000.0 11344.94 13200.97 10429.51 11126.67 12707.939999999999 10984.63 12280.45 11594.029999999999 6345.610000000001 10926.52 True False 11609.255028589547 11655.394295435548 9013.23982719765 9183.605957963737 11558.509070769032 10874.13459544604 11354.125769452987 11286.518661682961 10768.036704982764 12329.04527531771 0.9416183304826403 0.9453606532510034 0.7310574035478499 0.744875677952856 0.9375023623206848 0.8819932405646731 0.920924979664364 0.9154414157500217 0.8733877169337655 1.0 13.58977346559246 -6.338549200463598 24.999999999992507 0.9153055138777945 0.8403615600707368 0.22590657419009397 0.07273722545631736 213.56308293345978 69238.42305653689 0.024348512723781426 0.027608621573003003 4.586176868580678e-07 6.338549200463598 -0.07494395380705765 RGS(ph)GDTSSLIDPDTSLSELR ddPTM_A459_Selumetinib_30min_R2 3 RGSGDTSSLIDPDTSLSELR 20 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 RGS(0.999)GDT(0.001)SSLIDPDTSLSELR;RGS(0.7)GDT(0.263)S(0.026)S(0.01)LIDPDTSLSELR;RGS(0.534)GDT(0.197)S(0.189)S(0.081)LIDPDTSLSELR 102.79 0.00031836 244785600.0 68411.0 63369.5 65722.2 87623.0 77595.0 51137.4 73678.2 58309.9 57726.8 67546.4 True False 64608.990490931195 68229.73688494228 61493.7052049209 75688.596241894 67846.8223918986 58181.112670901755 77104.3822905836 58479.572155276415 69273.77302155709 65596.15992537644 0.9849508045048937 1.0401483404297118 0.9374589194684173 1.1538571210265802 1.034310887544066 0.8869591259166665 1.1754404888685428 0.8915090795223988 1.0560644571323134 1.0 16.001323739838334 -9.238889915949198 14.47582097437655 0.9999565544191287 1.017699459881746 0.003315096919714877 0.0928444792963199 0.0 0.0 0.08421678656069248 0.020425570967049 5.769126794714143e-10 9.238889915949198 0.017742905462617253 RGS(ph)IDSPK ddPTM_A459_Selumetinib_30min_R2 1 RGSIDSPK 8 1 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 RGS(0.91)IDS(0.09)PK 67.214 0.041102 9529100.0 45367.0 38768.0 39010.0 41203.0 33760.0 27291.0 49714.0 71835.0 44140.0 74017.0 True False 42845.683758490224 41741.38094123258 36500.139070876576 35591.08032086049 29518.766981770674 31050.087526968106 52025.79950642218 72044.02795707557 52969.23337464615 71879.93689073843 0.5960729184225368 0.5807097605647851 0.5077931429789491 0.49514623774588096 0.4106676808389644 0.4319715468610663 0.7237874956054057 1.0022828493378697 0.7369126305044255 1.0 16.13330152173817 -7.488877633779749 4.0376810739228866 0.9002335086965829 0.5045937784593886 0.815482463956705 0.08764483448159392 0.09189672430300444 3.2846874091917324 0.04155506546316731 0.02541261447952089 3.244310157126262e-08 7.488877633779749 -0.39563973023719434 RGS(ph)IGENQGEEK ddPTM_A459_Selumetinib_30min_R1 4 RGSIGENQGEEK 12 1 E7EX44;Q05682-3;Q05682-6;Q05682-2 E7EX44 CALD1 Caldesmon 1 RGS(1)IGENQGEEK;RGS(1)IGENQGEEK;RGS(1)IGENQGEEK;RGS(1)IGENQGEEK 144.4 0.0003827 63897000.0 18984.2 19758.1 21023.800000000003 22404.9 18540.1 17866.2 17627.6 16732.9 10935.5 14316.800000000001 True False 19426.49492317717 17444.8124667085 18168.883435467043 18492.304807061028 16863.15122852052 17686.482249211676 16297.935939937819 16289.089135880708 18556.74480268075 16154.500737441438 1.2025438135734026 1.0798732037738865 1.1246948284422589 1.1447153401776904 1.0438670623497908 1.094833107916455 1.008878962267397 1.0083313251598875 1.1487043211228192 1.0 13.979648543662625 -6.263335028526989 24.889207677913447 1.051294384417825 1.1328606868256026 0.41483521190876105 0.050582718608712204 171.19290373281243 2247700.2819842356 0.015000239978945453 0.017892066875825896 5.453370085314537e-07 6.263335028526989 0.08156630240777751 RGS(ph)IGENQGEEK ddPTM_A459_Selumetinib_30min_R2 3 RGSIGENQGEEK 12 1 E7EX44;Q05682-3;Q05682-6;Q05682-2 E7EX44 CALD1 Caldesmon 1 RGS(1)IGENQGEEK;RGS(1)IGENQGEEK;RGS(1)IGENQGEEK 91.657 0.011674 41954800.0 125898.0 129710.0 121402.0 144987.0 142765.0 104558.1 108760.0 112147.8 94475.8 125221.0 True False 118901.09316962541 139658.33991661345 113591.12749250322 125239.5204834745 124829.58436470645 118960.02919106973 113817.55550385147 112474.13153093224 113373.59987440851 121605.5443667695 0.9777604614063705 1.1484537209536734 0.9340949714423026 1.0298833094792512 1.0265122779946039 0.9782451105377173 0.9359569590064989 0.9249095681994861 0.9323061745644345 1.0 16.891849481574354 -6.94844586356687 2.8067562238466612 0.9423686979009559 1.0260484348534393 0.29510399750997396 0.05442183991270454 0.3148342757552406 5.039786096774379 0.020890655623228286 0.01739229123772827 1.1260408253514582e-07 6.94844586356687 0.08367973695248343 RGS(ph)IGENQIK ddPTM_A459_Selumetinib_30min_R1 2 RGSIGENQIK 10 1 Q05682-5;Q05682-4;E9PGZ1;C9J813 Q05682-5 CALD1 Caldesmon 1 RGS(1)IGENQIK;RGS(1)IGENQIK 143.76 0.0018948 41144000.0 6396.4 7162.0 4963.5 4802.6 5595.7 4958.299999999999 5731.799999999999 6039.0 3268.6 5557.299999999999 True False 6545.423674772205 6323.469710476533 4289.483962553898 3963.916065967326 5089.569923001074 4908.424003776194 5299.445711301346 5878.826102563424 5546.575470901404 6270.633587686024 1.0438217419729006 1.0084259623930611 0.6840590990641496 0.6321396411602614 0.8116516220937758 0.782763645035029 0.8451212524533643 0.9375170818636233 0.8845319046855981 1.0 12.614395505621111 -7.68807648349497 3.908083946787818 0.9345345770804709 0.8189144355455763 0.14711221093447058 0.12158970322306516 0.4976794172807544 14.772680601736896 0.07142659016474026 0.03759270597595279 2.0508009809621792e-08 7.68807648349497 -0.11562014153489464 RGS(ph)IGENQIK ddPTM_A459_Selumetinib_30min_R2 4 RGSIGENQIK 10 1 Q05682-5;Q05682-4;E9PGZ1;C9J813 Q05682-5 CALD1 Caldesmon 1 RGS(1)IGENQIK;RGS(1)IGENQIK;RGS(1)IGENQIK;RGS(1)IGENQIK 164.53 0.00019198 96254000.0 189523.0 146946.0 172710.0 195274.0 203430.0 173397.0 221555.0 232546.0 190846.0 171421.0 True False 178990.0703806806 158216.28569413844 161598.0266324297 168677.34433356128 177873.30471272534 197280.86280875324 231857.74650290373 233222.67035993724 229020.532682776 166471.63032475347 1.0751986391405317 0.9504099009872705 0.9707241186812653 1.0132497891953416 1.068490194790124 1.1850719694634877 1.3927763310216568 1.4009754689430602 1.3757331038087504 1.0 17.344916812231354 -6.85607794671298 2.226635806162753 1.3246215027349648 1.0004795253433731 0.5628700196843791 0.11433951977835287 0.19416605013730373 1.9687274131370984 0.04412413278940376 0.03825188230526386 1.392906783077276e-07 6.85607794671298 -0.3241419773915917 RGS(ph)IGENQVEVMVEEK ddPTM_A459_Selumetinib_30min_R1 2 RGSIGENQVEVMVEEK 16 1 Q05682 Q05682 CALD1 Caldesmon 1 RGS(1)IGENQVEVMVEEK;RGS(1)IGENQVEVMVEEK 188.44 4.6833e-07 17610400.0 8523.3 9983.0 11228.1 11152.900000000001 8167.0 9250.3 9768.9 8872.6 4832.0 7507.1 True False 8721.876306545233 8814.185719029212 9703.385691538519 9205.255380861825 7428.296292000965 9157.250380600395 9032.02400801349 8637.26982573344 8199.551084683219 8470.709410346353 1.029651223295666 1.0405487063767442 1.1455222014447268 1.0867159921243759 0.876939100629263 1.081048816220219 1.0662653587173623 1.0196631010837942 0.9679887111542352 1.0 13.048267083018928 RGS(ph)IGENQVEVMVEEK ddPTM_A459_Selumetinib_30min_R2 1 RGSIGENQVEVMVEEK 16 1 Q05682 Q05682 CALD1 Caldesmon 1 RGS(1)IGENQVEVMVEEK 101.48 0.0028007 2460600.0 27613.0 26000.0 28769.0 33172.0 30341.0 17418.0 25610.0 24926.0 18749.0 26950.0 True False 26078.38000359713 27994.116396823356 26918.033861318836 28653.91637510822 26529.29232801848 19817.1713951387 26800.91574525226 24998.530533278565 22499.32389083012 26171.883475490806 0.9964273311861089 1.0696255935511487 1.02850961744984 1.094835853214071 1.0136562144204249 0.757193169291652 1.0240346580463162 0.9551674244877695 0.8596753807153418 1.0 14.675730132096364 -6.540314263006502 24.99980483661158 0.918792392455483 1.048426439230951 0.41004526833087673 0.07369308504007624 232.85628117042845 333877.15383635345 0.023489173546045582 0.02349317558951858 2.881945322885775e-07 6.540314263006502 0.12963404677546797 RGS(ph)LCATCGLPVTGR ddPTM_A459_Selumetinib_30min_R1 1 RGSLCATCGLPVTGR 15 1 O43294-2;O43294 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 RGS(0.935)LCAT(0.065)CGLPVTGR 88.637 0.031285 7830400.0 755.04 876.59 1216.0 1306.6 1150.6 1301.3 868.41 1217.9 782.61 671.92 True False 772.6309629479089 773.9584352843655 1050.87387900988 1078.4268379196492 1046.5284331549294 1288.2101034858651 802.9051345390983 1185.5973357032624 1328.032010427139 758.1674770550437 1.0190769009890082 1.0208277969013637 1.3860709022916655 1.4224124227915864 1.3803393904734196 1.6991102130754414 1.0590076188150794 1.5637670720306918 1.7516341054164246 1.0 9.566372760636009 -5.284056048832491 4.216663574608779 1.428572578753535 1.0119094556528943 0.31512706437467397 0.22776685146472672 0.21732007891851082 9.345694392061224 0.05809321509770043 0.1424652606424279 5.199288916332611e-06 5.284056048832491 -0.4166631231006408 RGS(ph)LEMSSDGEPLSR ddPTM_A459_Selumetinib_30min_R1 4 RGSLEMSSDGEPLSR 15 1 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 RGS(0.999)LEMS(0.001)S(0.001)DGEPLSR;RGS(0.887)LEMS(0.057)S(0.057)DGEPLSR;RGS(0.984)LEMS(0.008)S(0.008)DGEPLSR;RGS(0.882)LEMS(0.059)S(0.059)DGEPLSR 183.76 3.595e-05 55082000.0 6866.2 7445.2 8211.800000000001 8931.0 7864.6 6990.9 6569.0 6702.6 4314.14 5483.9 True False 7026.169100700538 6573.512522820425 7096.6826641885955 7371.368505633236 7153.248318607901 6920.577893229334 6073.495041267759 6524.825274886836 7320.7804876811415 6187.81198270948 1.1354852281119188 1.0623322979412921 1.1468807850042568 1.1912722180685116 1.156022248025009 1.11842084287102 0.9815254662292334 1.0544640485391392 1.1830967890002961 1.0 12.59521364568084 -7.021169405876959 23.60736271954326 1.0579763582524369 1.137545347899303 0.3177101871338093 0.058180602693261016 505.22406464245114 563406.3628146432 0.02275180283973647 0.017839335643947168 9.524245779225767e-08 7.021169405876959 0.0795689896468661 RGS(ph)LEMSSDGEPLSR ddPTM_A459_Selumetinib_30min_R2 2 RGSLEMSSDGEPLSR 15 1 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 RGS(0.961)LEMS(0.019)S(0.019)DGEPLSR;RGS(0.986)LEMS(0.01)S(0.004)DGEPLSR 164.8 0.00016425 19704300.0 44638.0 44883.0 52612.0 50537.0 48605.0 36975.0 38811.0 38724.0 42757.0 48586.0 True False 42157.19866007198 48325.38177840858 49227.00119961443 43653.77341881239 42498.80536578685 42067.97062436871 40615.78840253752 38836.680428896696 51309.594730397504 47183.1959384117 0.8934790834241038 1.02420747084381 1.0433163803458865 0.9251974680942284 0.9007190912048563 0.8915879856735457 0.8608104558146796 0.8231040661084145 1.087454838739029 1.0 15.525985521915288 RGS(ph)LPAEASCTT ddPTM_A459_Selumetinib_30min_R2 1 RGSLPAEASCTT 12 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 RGS(0.998)LPAEAS(0.002)CTT 92.151 0.039616000000000005 7993100.0 50372.0 33370.0 40026.0 45899.0 40655.0 26312.0 31753.0 35777.0 28354.0 32700.0 True False 47572.52589509267 35929.37169853829 37450.77073701374 39647.477019808626 35547.55543968861 29936.239163445283 33229.57741737586 35881.105146798815 34025.59227695328 31755.866035196603 1.498070493255189 1.1314247156325696 1.1793339440185695 1.2485087629436828 1.1194012281160743 0.9426995040936834 1.0464075324082132 1.1299047900954742 1.0714742353189495 1.0 14.95473549484194 -1.5228787452803376 0.5773746419425901 1.0611885026792072 21.675271020257433 0.6908883994914805 0.0813346577458285 97.81324985128599 0.8191480206824159 0.040751452057546954 2525.49720473061 0.029999999999999995 1.5228787452803376 20.614082517578225 RGS(ph)LPDQK ddPTM_A459_Selumetinib_30min_R2 2 RGSLPDQK 8 1 X6RKU3;Q6P3S6 X6RKU3 FBXO42 F-box only protein 42 1 RGS(1)LPDQK;RGS(1)LPDQK 90.913 0.01417 18044800.0 210608.0 131412.0 139141.0 186039.0 165544.0 91921.0 137258.0 138894.0 112222.0 129401.0 True False 198903.2504906234 141490.87784382128 130188.81954526651 160700.16726482467 144746.88273786282 104582.28337424189 143640.76897156716 139298.15854486052 134669.53574466592 125664.85690582532 1.5828072811134761 1.1259383198108932 1.036000221150385 1.2787995882194432 1.1518485462195511 0.832231746801073 1.1430464531481002 1.1084893738370478 1.0716563012170444 1.0 16.939221720404888 -4.762496066554078 4.6219535252947175 1.0846559031151584 1.621622527425595 0.6542817635898619 0.10937236960212997 0.12477468581356596 6.135070703194684 0.02804067322212345 0.22206812572467038 1.7278416296609546e-05 4.762496066554078 0.5369666243104367 RGS(ph)LPDTGWK ddPTM_A459_Selumetinib_30min_R2 1 RGSLPDTGWK 10 1 O75096 O75096 LRP4 Low-density lipoprotein receptor-related protein 4 1 RGS(1)LPDTGWK 95.428 0.011693 1688000.0 36328.0 16707.0 22384.0 26435.0 23284.0 17693.0 31243.0 22726.0 19398.0 21319.0 True False 34309.0351925063 17988.37317852798 20943.837809856486 22834.507397081445 20358.855758398946 20130.05014893726 32695.86140683002 22792.12889750816 23278.14202540522 20703.465076585824 1.6571639126876123 0.8688580926905601 1.0116102658362491 1.1029316741237525 0.9833549931418675 0.9723034320328795 1.5792458550238897 1.100884746258464 1.124359711734012 1.0 14.337584627005715 RGS(ph)LQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDER ddPTM_A459_Selumetinib_30min_R1 1 RGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDER 36 2 P46934-3;P46934-2;P46934;H0Y8X6;P46934-4 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 RGS(0.856)LQAY(0.103)T(0.04)FEEQPTLPVLLPTSSGLPPGWEEKQDER 69.385 1.2582e-05 10818000.0 551.06 670.58 586.9 847.45 569.29 563.39 586.96 610.97 411.9 429.51 True False 563.8986258238964 592.068181855816 507.20220361093624 699.4587661066943 517.7978200163127 557.7228081171916 542.685134635793 594.765090889746 698.9642160142836 484.6417922816883 1.1635369355355587 1.221661423519349 1.046550693086194 1.4432489670642104 1.0684134720997258 1.1507938791069556 1.1197654500261673 1.2272261706725671 1.442228522479598 1.0 8.920775008344027 -7.991065577696123 23.52018872909823 1.2589852584961447 1.1756989954074222 0.011081022016507402 0.1436778339090568 277.59037753714375 730766.7108900168 0.07440990632897006 0.03564471680568938 1.0207853352956327e-08 7.991065577696123 -0.08328626308872256 RGS(ph)LSNAGDPEIVK ddPTM_A459_Selumetinib_30min_R1 2 RGSLSNAGDPEIVK 14 1 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 RGS(0.949)LS(0.051)NAGDPEIVK;RGS(0.941)LS(0.059)NAGDPEIVK 161.95 0.00014340000000000002 112213000.0 25948.6 31227.0 27415.8 28152.0 26072.9 26907.5 28052.6 27145.9 14424.7 21983.3 True False 26553.151892813774 27570.92832296155 23692.884944209767 23235.781678489187 23714.61079854436 26636.834980055246 25936.56979672217 26425.90254968976 24477.662361595627 24805.070690475262 1.0704727361655835 1.1115037190177544 0.9551629680824673 0.9367351525997201 0.9560388315140089 1.0738463644162624 1.0456156372366794 1.0653427631567634 0.9868007500174005 1.0 14.598347448235504 -6.777180843496201 24.991891587186792 1.0391109169226467 1.0051745415371944 0.05681224433898591 0.05601086619429966 765.9344578578173 1216028.2647189833 0.021944621785869787 0.01941979931657742 1.6703949044408317e-07 6.777180843496201 -0.033936375385452244 RGS(ph)LSNAGDPEIVK ddPTM_A459_Selumetinib_30min_R2 4 RGSLSNAGDPEIVK 14 1 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 RGS(0.965)LS(0.035)NAGDPEIVK;RGS(0.951)LS(0.049)NAGDPEIVK;RGS(0.898)LS(0.102)NAGDPEIVK;RGS(0.985)LS(0.015)NAGDPEIVK 171.25 7.4116e-05 257942000.0 855156.0 655577.0 800113.0 880927.0 849547.0 656108.0 705921.0 692891.0 559027.0 774444.0 True False 807629.852980701 705857.6478877023 748634.6006771679 760943.2229161644 742819.3108134583 746480.9214445793 738747.7252559239 694907.1980957199 670848.0205194462 752083.7894728377 1.073856216934017 0.9385359155027967 0.9954138237734289 1.0117798489574368 0.987681587093011 0.9925502076940315 0.982267847806876 0.9239757694854787 0.8919857466807887 1.0 19.52053387559895 -7.66680756646175 4.2669670596244185 0.931004038706503 0.9962434157439879 0.3103678370433922 0.040070220328063816 0.23759445567676163 7.798522938867261 0.01928265590759276 0.0104536192905936 2.1537358320406896e-08 7.66680756646175 0.06523937703748495 RGS(ph)LTLTISGESPK ddPTM_A459_Selumetinib_30min_R1 1 RGSLTLTISGESPK 14 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RGS(0.939)LT(0.058)LT(0.003)ISGESPK 64.83 0.03788 30144000.0 6314.3 6451.9 7472.3 7725.6 6305.2 5867.6 6777.1 5665.9 3565.0 5768.9 True False 6461.410904510992 5696.508548593061 6457.60270240586 6376.468987472864 5734.895773273476 5808.57727135454 6265.897890725484 5515.621926563028 6049.544622701921 6509.394508844572 0.9926285610330757 0.8751211100898847 0.992043529337738 0.9795794338181383 0.8810183136820554 0.8923375689493388 0.9625930464364636 0.8473325620483955 0.929355966132052 1.0 12.668307637620828 -6.255463177134057 24.978634616653203 0.9120087774308178 0.9560916094164819 0.1256506986064957 0.050860512253287256 954.7696280203611 3990629.5248495755 0.014620447620639014 0.018374970215942733 5.553116987709298e-07 6.255463177134057 0.044082831985664095 RGS(ph)LTLTISGESPK ddPTM_A459_Selumetinib_30min_R2 3 RGSLTLTISGESPK 14 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RGS(0.708)LT(0.266)LT(0.027)ISGESPK;RGS(0.976)LT(0.021)LT(0.003)ISGESPK;RGS(0.935)LT(0.059)LT(0.006)ISGESPK 102.84 0.0037512 14052500.0 179333.0 138728.0 155991.0 173222.0 150896.0 121413.0 132739.0 135045.0 108378.0 140659.0 True False 169366.3897868786 149367.99151917352 145954.7088901592 149628.86477538294 131939.09545264416 138136.53867252142 138911.62651733845 135437.9585920967 130056.62833433154 136597.8091940284 1.239890967404203 1.0934874607469427 1.0684996322513485 1.0953972516707406 0.965894667206801 1.011264671721838 1.0169389050744102 0.9915090102193058 0.9521135741613137 1.0 17.059574819775968 -1.5228787452993202 0.4497224643334357 0.9844838116966343 6.500669042746897 0.8514532125065957 0.031097368011886645 31.766714142064245 0.3829019042581378 0.01952535594503324 160.87829853371136 0.029999999998688725 1.5228787452993202 5.516185231050263 RGS(ph)MEQAPAVALPPTHK ddPTM_A459_Selumetinib_30min_R2 1 RGSMEQAPAVALPPTHK 17 1 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 RGS(1)MEQAPAVALPPTHK 81.574 0.010537 2171300.0 21768.0 18803.0 20335.0 25826.0 18849.0 15030.0 16543.0 17094.0 17363.0 16099.0 True False 20558.221704208237 20245.12963882574 19026.668239073948 22308.454247665046 16481.020107802004 17100.246071244397 17312.282279332627 17143.74070993596 20836.085162754443 15634.180039774625 1.3149536241687412 1.2949274977850123 1.2169917572055942 1.4269027343238037 1.0541659406424224 1.0937731321847377 1.1073354813164984 1.0965551545601298 1.3327264435835937 1.0 13.932415936287857 -6.272599740384224 24.990388380557288 1.1175666087334974 1.3052318671795455 0.5191112741488368 0.09382879260682735 617.6457745592664 1383035.575167963 0.028435487555282697 0.03254626739862768 5.338266604788036e-07 6.272599740384224 0.1876652584460481 RGS(ph)MNNELLSPEFGPVRDPLADGVEGLGR ddPTM_A459_Selumetinib_30min_R1 1 RGSMNNELLSPEFGPVRDPLADGVEGLGR 29 2 O00562-2;O00562 O00562-2 PITPNM1 Membrane-associated phosphatidylinositol transfer protein 1 1 RGS(0.999)MNNELLS(0.001)PEFGPVRDPLADGVEGLGR 43.303 0.023027 2646900.0 292.66 280.85 278.07 268.4 208.34 246.81 298.43 154.91 173.06 170.29 True False 299.4784085827705 247.96795143637712 240.30962132917563 221.5289784919898 189.49568378541454 244.32731548555014 275.9191848326287 150.80128358140428 293.67018019769847 192.14838026506644 1.5585788866377304 1.2905024288745408 1.2506460944280213 1.1529057813882853 0.9861945415517293 1.2715554258042845 1.4359693506237283 0.7848168346429758 1.5283510576179924 1.0 7.586077004877469 -4.48973681652058 1.2729890625937146 1.1684225825412051 1.985034837372733 0.2440499374067383 0.2060299880152585 3.731357334636658 3.2572685170473776 0.057538507649849635 4.759913117488363 3.237898148783416e-05 4.48973681652058 0.8166122548315278 RGS(ph)MS(ph)S(ph)VT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 RGSMSSVTK 9 1 E9PDV9;B3KU01;H0Y8V9;A0A0A0MQU6;Q9H2E6;Q9H2E6-2 E9PDV9 SEMA6A Semaphorin-6A 4 RGS(1)MS(1)S(1)VT(1)K 40.268 0.047685000000000005 0.0 13259.0 13965.0 13085.0 10857.0 12655.0 8204.1 11395.0 10804.0 9147.7 10619.0 True False 12522.117859982402 15036.070595447618 12243.1253458708 9378.257870630354 11065.16576286457 9334.14030559522 11924.890078764147 10835.437851301514 10977.495608093584 10312.401878524548 1.2142775279209745 1.4580570823912569 1.1872234509563635 0.9094154767339374 1.0729959802970483 0.9051373691160596 1.1563639799179652 1.0507191223672327 1.0644945510661377 1.0 13.33209277187377 -5.528680328899466 6.19221985145975 1.0283135779810595 1.3344774121021659 0.6669931274371772 0.08953411749783284 0.07697292360646144 12.54091991916045 0.023022963451919228 0.042803211966075304 2.960190572044414e-06 5.528680328899466 0.30616383412110637 RGS(ph)PAPANPGR ddPTM_A459_Selumetinib_30min_R2 1 RGSPAPANPGR 11 1 E9PJN1;O75676-2;O75676 E9PJN1 RPS6KA4 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-4 1 RGS(1)PAPANPGR 103.14 0.024405 2946000.0 17660.0 18302.0 17647.0 19599.0 22026.0 15033.0 13452.0 15580.0 12979.0 17035.0 True False 16678.527898581295 19705.70454979464 16511.611232600833 16929.582389839194 19258.896965061635 17103.659294013112 14077.544654632324 15625.335220592144 15575.162663559862 16543.155287754566 1.0081829982534791 1.1911696533720522 0.9980932261950608 1.0233587302641514 1.1641610460682366 1.0338813241191926 0.8509588654500925 0.9445196486886753 0.9414868199350566 1.0 14.013946806552841 -7.052009134901836 7.470473999727947 0.9308115873066304 1.0782673696776472 0.4979889172031162 0.06779175643476124 0.22311846531261728 28.31405364451041 0.0251884456413417 0.01965315495747488 8.871373518933088e-08 7.052009134901836 0.14745578237101686 RGS(ph)PCSMLSLK ddPTM_A459_Selumetinib_30min_R2 1 RGSPCSMLSLK 11 1 O95935 O95935 TBX18 T-box transcription factor TBX18 1 RGS(1)PCSMLSLK 98.676 0.0092469 7491300.0 39847.0 36373.0 34874.0 43613.0 44890.0 35460.0 33776.0 34931.0 27432.0 38039.0 True False 37632.46326017941 39162.69214237136 32630.244807940246 37672.83416337862 39250.51687830824 40344.29312616941 35346.65092587431 35032.64342686165 32919.16651412083 36940.71523280869 1.0187258969679165 1.0601498074836742 0.8833138341338848 1.0198187535340328 1.062527258363642 1.0921362207502103 0.9568480388945306 0.9483477297631641 0.8911350607766212 1.0 15.17292417908141 -7.495201115685224 23.154163044775686 0.9423643778505011 1.0202004059191465 0.28124282694792146 0.05769284211951037 386.10893034486526 323007.09316108277 0.02544080084578404 0.017088203397483227 3.197414089164951e-08 7.495201115685224 0.07783602806864542 RGS(ph)PSAAFTFPDTDDFGK ddPTM_A459_Selumetinib_30min_R1 3 RGSPSAAFTFPDTDDFGK 18 1 Q9ULT0;Q9ULT0-4;H7C055;Q9ULT0-3 Q9ULT0 TTC7A Tetratricopeptide repeat protein 7A 1 RGS(0.964)PS(0.036)AAFTFPDTDDFGK;RGS(0.924)PS(0.075)AAFT(0.001)FPDTDDFGK;RGS(0.771)PS(0.229)AAFTFPDTDDFGK 145.67 0.00013538 53269000.0 10570.16 11285.7 11186.400000000001 12306.4 9919.8 10073.06 10007.91 9611.26 5869.28 8283.45 True False 10816.424162048987 9964.364997420407 9667.34832249682 10157.318259738538 9022.55584148293 9971.734162006709 9253.005291285433 9356.338163027609 9959.739484749494 9346.711495135734 1.157243825026388 1.0660824400759685 1.0343047742008462 1.0867264133513337 0.9653187483296662 1.066870863318746 0.9899744199979781 1.001029952395223 1.065587558782872 1.0 13.190243147612092 -1.5228789989560791 0.7069320077045139 1.019451071654029 18.73244105763267 0.5623975225105003 0.035689752907708525 211.14396107151683 1.089873135184159 0.013232433067279316 5918.350809512158 0.029999982476705687 1.5228789989560791 17.71298998597864 RGS(ph)PSAAFTFPDTDDFGK ddPTM_A459_Selumetinib_30min_R2 2 RGSPSAAFTFPDTDDFGK 18 1 Q9ULT0;Q9ULT0-4;H7C055;Q9ULT0-3 Q9ULT0 TTC7A Tetratricopeptide repeat protein 7A 1 RGS(0.751)PS(0.249)AAFTFPDTDDFGK;RGS(0.5)PS(0.5)AAFT(0.001)FPDTDDFGK 123.12 0.00045927 4827100.0 36458.0 29189.3 40377.0 39902.0 35937.0 30613.2 30817.1 29420.0 25909.6 38173.0 True False 34431.81031293754 31428.02545160753 37779.187779153624 34467.278765210656 31422.27277914376 34829.89042103916 32250.156212925158 29505.607329256818 31092.243974710742 37070.84630463487 0.928811013106885 0.8477827884840645 1.0191077772732207 0.92976778792615 0.8476276079840971 0.9395493735109164 0.8699600744991086 0.7959248377226233 0.838724957051314 1.0 15.177997430923481 -6.754912851345929 1.2741818488862515 0.8646217698497488 0.9266668580003835 0.061376384674288076 0.06739812351026025 0.9674781718700985 3.3018096443621547 0.03299941842677933 0.029939311592040205 1.7582764069494024e-07 6.754912851345929 0.0620450881506347 RGS(ph)PTTGFIEQK ddPTM_A459_Selumetinib_30min_R1 6 RGSPTTGFIEQK 12 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RGS(0.894)PT(0.089)T(0.018)GFIEQK;RGS(0.978)PT(0.019)T(0.003)GFIEQK;RGS(0.999)PT(0.001)TGFIEQK;RGS(0.998)PT(0.001)T(0.001)GFIEQK;RGS(0.984)PT(0.014)T(0.002)GFIEQK;RGS(0.973)PT(0.027)TGFIEQK 195.94 0.00029728 257727000.0 32615.9 37881.1 35501.5 39540.2 35743.0 32145.8 35259.4 34053.3 19372.6 30886.700000000004 True False 33375.78701050634 33445.96320155437 30680.591295780647 32635.246331479037 32510.05196093917 31822.442438051115 32599.755070494215 33150.09586329247 32873.88728127775 34851.3088069354 0.9576623705983912 0.9596759589957963 0.880328238624864 0.9364137947377354 0.9328215517251874 0.9130917468361608 0.9353954323806306 0.9511865407102189 0.9432611975460691 1.0 15.088925215666672 -8.970480854788079 0.8147501273458507 1.0002609325212168 0.9297229194324464 0.4650369280660501 0.021691711167416382 1.3744106401651548 1.528759798856663 0.022856319240310754 0.007602263581987388 1.0703335658992696e-09 8.970480854788079 -0.07053801308877039 RGS(ph)PTTGFIEQK ddPTM_A459_Selumetinib_30min_R2 2 RGSPTTGFIEQK 12 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RGS(0.989)PT(0.011)T(0.001)GFIEQK;RGS(0.996)PT(0.003)T(0.001)GFIEQK 139.0 0.00061291 138620000.0 552570.0 491290.0 584150.0 581600.0 586360.0 418999.0 490400.0 455200.0 408785.0 475820.0 True False 521860.3715129703 528970.3632536661 546566.4249744295 502385.0766840397 512696.2146750909 476712.3089557765 513204.5717091652 456524.55663758283 490553.42240722204 462081.8402711695 1.1293678435982686 1.1447547104280131 1.1828346784926256 1.0872209918252111 1.1095355194530447 1.0316620724069598 1.1106356644701612 0.987973377983594 1.0616158863099754 1.0 18.81778886741339 -6.713036107047009 0.5614280157345409 1.0131837344709274 1.1606770871016638 0.6404953440148577 0.03617644667303202 0.5627852931606054 0.38449646560630135 0.02907978919645703 0.036504785642558775 1.9362609773916761e-07 6.713036107047009 0.14749335263073649 RGS(ph)PVPPVPER ddPTM_A459_Selumetinib_30min_R1 2 RGSPVPPVPER 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RGS(1)PVPPVPER;RGS(1)PVPPVPER 78.32600000000002 0.024537 111132000.0 3979.3999999999996 4802.8 4313.9 4700.1 4315.7 4536.9 4302.5 4358.9 2248.13 3571.0 True False 4072.1122774355135 4240.485943238855 3728.0960745565153 3879.315766804028 3925.345696998718 4491.262905175611 3977.958961037378 4243.287812297354 3814.9124130813116 4029.372634485598 1.0106070216946743 1.0523935927261807 0.9252299086585858 0.9627592478299722 0.9741828450919232 1.1146308154120323 0.9872402782983649 1.0530889538438197 0.9467757785495395 1.0 11.976339516076935 RGS(ph)PVPPVPER ddPTM_A459_Selumetinib_30min_R2 2 RGSPVPPVPER 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RGS(1)PVPPVPER;RGS(1)PVPPVPER 75.02 0.027758 134079800.0 58495.0 45872.6 63170.0 52847.0 56061.0 46265.0 46764.0 50926.0 43248.0 49521.0 True False 55244.082074038066 49390.88091634304 59105.71097429563 45649.14743384011 49018.115988301106 52637.58379814517 48938.618661108034 51074.186228746876 51898.80845008375 48091.20005898998 1.148735777154119 1.0270253363558994 1.2290338128762632 0.949220384973667 1.019274127661072 1.0945367080376132 1.0176210741482554 1.0620276925112677 1.0791747427060097 1.0 15.553485306959821 -5.768749815281685 24.999997445838122 1.035792673395492 1.1241410150370776 0.37555333963443704 0.06036471044892131 193.84300998644972 662900.6637025649 0.016517820847943402 0.025069279468233566 1.703139356067368e-06 5.768749815281685 0.08834834164158556 RGS(ph)SDPTVQR ddPTM_A459_Selumetinib_30min_R2 1 RGSSDPTVQR 10 1 Q2KHT3;A0A2R8YDG4;H7BZJ9;H7BZI2;Q2KHT3-2;H7BXG1 Q2KHT3;H7BXG1 CLEC16A Protein CLEC16A 1 RGS(0.91)S(0.058)DPT(0.032)VQR 92.295 0.048173 1661200.0 9183.7 5325.7 8042.6 8350.7 7590.1 3308.9 4431.3 5918.5 4829.1 4826.8 True False 8673.306719263925 5734.164065175462 7525.147872120789 7213.320254239006 6636.563781645073 3764.670939796446 4637.364230454371 5935.72185513958 5795.054936327679 4687.437742467495 1.8503300087988463 1.2233045813547092 1.6053862014942744 1.5388620927990975 1.4158190777700967 0.8031404674859107 0.9893175088898856 1.2663041476503922 1.236294806398245 1.0 12.19458381372226 -6.592246234081171 6.985554064136544 1.072315043668612 1.5276939019512465 0.6130375079156434 0.18770999251372472 0.16161377193069007 13.321114901888174 0.06272015410640994 0.06274104168029357 2.557135644029625e-07 6.592246234081171 0.4553788582826346 RGS(ph)SGSVDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R1 3 RGSSGSVDETLFALPAASEPVIR 23 1 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 RGS(0.333)S(0.333)GS(0.333)VDETLFALPAASEPVIR;RGS(0.691)S(0.231)GS(0.078)VDETLFALPAASEPVIR;RGS(0.58)S(0.21)GS(0.21)VDETLFALPAASEPVIR 182.98 2.2676999999999997e-17 61306100.0 6208.6 8064.200000000001 6224.0 5445.5 6833.299999999999 7128.3 7774.700000000001 8731.0 3927.4 6890.3 True False 6353.2483001673945 7120.039715055131 5378.814985984785 4494.545649694971 6215.229221517103 7056.5957739785545 7188.248119553122 8499.425517715063 6664.510954053162 7774.737122205574 0.8171656739392206 0.9157916985668171 0.6918323927148932 0.5780961566993711 0.7994134237369478 0.907631430241426 0.9245647803348398 1.0932106621894253 0.857200809403385 1.0 12.924578180625339 -6.856014737261027 2.508654553435977 0.9731164632292651 0.7522083516857907 0.5098832185602227 0.09820600295579777 0.2544032714279764 3.2618554001911257 0.041435188300883906 0.036204919031113836 1.393109528646495e-07 6.856014737261027 -0.22090811154347445 RGS(ph)SGSVDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R2 5 RGSSGSVDETLFALPAASEPVIR 23 1 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 RGS(0.637)S(0.181)GS(0.181)VDETLFALPAASEPVIR;RGS(0.333)S(0.333)GS(0.333)VDETLFALPAASEPVIR;RGS(0.637)S(0.181)GS(0.181)VDETLFALPAASEPVIR;RGS(0.434)S(0.131)GS(0.434)VDET(0.001)LFALPAASEPVIR;RGS(0.578)S(0.211)GS(0.211)VDETLFALPAASEPVIR 163.1 2.5445e-10 55175000.0 121326.6 42242.9 92766.2 117364.0 72145.8 75737.0 153685.7 118248.3 110680.4 76788.2 True False 114583.75328086136 45482.79459766806 86797.72368820159 101378.82073580749 63082.19961236467 86169.08427796645 160832.38957243724 118592.38297594004 132819.5726687625 74571.12514629633 1.5365699934936856 0.6099250146546437 1.1639588851303864 1.359491633483052 0.8459333218937991 1.1555288204236804 2.1567649577086367 1.5903257828453201 1.7811126278193103 1.0 16.186329488952587 -7.096085516153874 9.162679575851648 1.6802336403518232 1.0842371189518962 0.3340816736676758 0.3572983782584618 0.3830087294416226 33.9344213979073 0.1289038572938857 0.09986136510904291 8.015202219269571e-08 7.096085516153874 -0.595996521399927 RGS(ph)SPGSLEIPK ddPTM_A459_Selumetinib_30min_R1 2 RGSSPGSLEIPK 12 1 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 RGS(0.424)S(0.424)PGS(0.151)LEIPK;RGS(0.498)S(0.498)PGS(0.005)LEIPK 120.32 0.0020851 12363000.0 11706.5 14239.5 14245.2 15675.2 13402.5 12764.0 13083.7 12400.2 6425.2 10565.0 True False 11979.23867311625 12572.332720236041 12310.780083282518 12937.820579946496 12190.246241403556 12635.605748784736 12096.785975252704 12071.306414473753 10903.095121959159 11921.120661814704 1.0048752137446026 1.0546267483481881 1.032686475753572 1.0852855991457622 1.0225755268505003 1.0599343893278963 1.014735637564737 1.0125982914626575 0.9146032014325257 1.0 13.541232244313171 -7.921392016208013 2.3910888458107067 0.9586478511922638 1.0427296384286289 0.5303852318950287 0.029904583955847646 0.21043909482200915 2.312005895333002 0.020839378430012455 0.00774997683094631 1.198417062807562e-08 7.921392016208013 0.08408178723636506 RGS(ph)SPGSLEIPK ddPTM_A459_Selumetinib_30min_R2 3 RGSSPGSLEIPK 12 1 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 RGS(0.646)S(0.354)PGSLEIPK;RGS(0.492)S(0.492)PGS(0.017)LEIPK;RGS(0.499)S(0.499)PGS(0.001)LEIPK 101.04 0.006621600000000001 41525200.0 629446.0 541627.0 593908.0 628499.0 582521.0 438819.0 544563.0 539490.0 411255.0 544541.0 True False 594463.911191981 583168.0492947007 555696.6058781368 542896.3519787518 509339.50417618547 499262.33404773055 569886.2585311141 541059.826582623 493517.491424787 528818.686442569 1.1241355996532874 1.10277504226968 1.0508263420424475 1.026620968390669 0.9631647240050791 0.9441087216609764 1.077659078889235 1.0231480854475883 0.9332451822849572 1.0 19.012413631542834 -5.477968583716971 1.5591863762753595 0.9941493888356644 1.1236752337252787 0.599345308623971 0.03939306402816629 0.3310219797796776 1.4929847460696912 0.012816838711991642 0.043081667269385344 3.326836183123875e-06 5.477968583716971 0.12952584488961427 RGS(ph)SSDEEGGPK ddPTM_A459_Selumetinib_30min_R1 2 RGSSSDEEGGPK 12 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 RGS(0.978)S(0.022)SDEEGGPK;RGS(0.992)S(0.007)SDEEGGPK 153.41 0.00084333 5454500.0 1174.6100000000001 3960.5 2858.1000000000004 1877.06 1554.99 1958.9 1465.72 1870.6 2511.6 1634.66 True False 1201.9761276068066 3496.8028188135013 2469.985718419521 1549.2667077800838 1414.3414290557828 1939.1952445388918 1355.1595603420571 1820.985611434864 4262.001759993869 1844.4845339367744 0.6516596401279493 1.8958157438978913 1.3391197773546568 0.8399456212698121 0.7667949516698218 1.0513480643830457 0.7347090937377898 0.9872598972398238 2.310673622671841 1.0 10.849001976700368 -10.23270566226988 10.07356271336445 1.0000000000489235 1.1572639291385027 0.009293128367205306 0.5134538939262856 0.0 0.0 0.49659583454439465 0.12044218112166417 5.85186552749038e-11 10.23270566226988 0.1572639290895792 RGS(ph)SSDEEGGPK ddPTM_A459_Selumetinib_30min_R2 2 RGSSSDEEGGPK 12 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 RGS(0.994)S(0.004)S(0.001)DEEGGPK;RGS(0.912)S(0.083)S(0.005)DEEGGPK 142.57 0.00046089 4447600.0 15163.2 15650.0 17056.3 18987.1 17958.3 21052.8 48031.0 154408.0 28784.0 59018.1 True False 14320.490047098972 16850.304677318672 15958.916227495305 16401.024225425568 15702.217804761036 23952.63210170951 50264.53667162092 154857.3017163796 34541.604292157135 57314.09410556081 0.24985983413998597 0.2939993197185297 0.27844662777190987 0.286160402277636 0.2739678267589953 0.41791870700413886 0.8770013284872643 2.701906121575684 0.6026720797250774 1.0 15.80660233521381 -7.526340579800176 24.996437432777412 1.5492643344016055 0.32618960314168755 0.5019068466351693 0.5047966733479791 74.96578524863774 541279.702206943 0.21979827838694307 0.1276919755937109 2.9761815508746463e-08 7.526340579800176 -1.223074731259918 RGS(ph)SSSSPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R1 3 RGSSSSSPEHSASSDSTK 18 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 RGS(0.381)S(0.257)S(0.257)S(0.095)S(0.01)PEHSASSDSTK;RGS(0.596)S(0.094)S(0.094)S(0.094)S(0.123)PEHSASSDSTK;RGS(0.705)S(0.184)S(0.064)S(0.023)S(0.023)PEHSASSDSTK 77.657 0.006973600000000001 6901230.0 989.476 1057.69 1244.9 1068.5900000000001 1194.8 1406.43 1033.52 1416.3600000000001 345.226 722.72 True False 1012.5288656148612 933.8551630932592 1075.8494177462176 881.9808164186122 1086.7305509590726 1392.2825911362684 955.5607543082742 1378.7935318143295 585.823307690573 815.4881518889465 1.2416230245277036 1.1451486584202784 1.319270445872434 1.0815372539449484 1.3326135375993347 1.7072995946185985 1.1717653433650412 1.6907585090238002 0.718371329287382 1.0 9.67152010615366 -8.279371999156671 24.999270964803237 0.8591856024413401 1.327589477058089 0.45168531283840263 0.21007646328136662 866.9226641453848 1208536.5070266407 0.198397348240939 0.051667734810848735 5.255668941050149e-09 8.279371999156671 0.4684038746167488 RGS(ph)SSSSPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R2 1 RGSSSSSPEHSASSDSTK 18 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 RGS(0.382)S(0.382)S(0.079)S(0.079)S(0.079)PEHSASSDSTK 74.51899999999998 0.0083181 2073300.0 5111.8 4357.5 5116.9 8144.4 8730.4 4719.0 6259.9 8114.4 7531.5 11365.0 True False 4827.706620156727 4691.706238429142 4787.684224859478 7035.11867012635 7633.609101233735 5368.999415183121 6550.997753756525 8138.0115605887695 9038.010447692517 11036.862920183781 0.4374165607627514 0.4250941841317186 0.4337903133782652 0.6374201365916035 0.6916466351388392 0.48646064139878964 0.5935561401035722 0.7373482500816689 0.8188930598353413 1.0 13.430042543274343 -8.069586221986773 0.12087621126870031 1.3663628154757639 0.06684989825233141 0.8280234901420269 0.07502722561492661 3.0399741104241085 0.369906738469431 1.8362814574782014 1.7275589141523617 8.519493541338578e-09 8.069586221986773 -1.2995129172234325 down RGS(ph)TCVLAGMATDFGNMPEQK ddPTM_A459_Selumetinib_30min_R2 1 RGSTCVLAGMATDFGNMPEQK 21 1 H0YB94;P49675 H0YB94 STAR Steroidogenic acute regulatory protein, mitochondrial 1 RGS(0.81)T(0.19)CVLAGMAT(0.001)DFGNMPEQK 50.397 0.043363 8262800.0 48557.0 57178.0 48385.0 50645.0 55875.0 45451.0 50295.0 40757.0 29198.0 52226.0 True False 45858.39632907199 61563.36874375253 45271.96177760478 43747.06363250196 48855.48297116224 51711.462686901425 52633.817157651836 40875.59612231542 35038.41586028364 50718.09968055591 0.9041820694763331 1.2138342944925917 0.8926194408455125 0.8625532878408203 0.9632751084696544 1.0195859665997373 1.0377718701836607 0.8059370595461434 0.6908463858261732 1.0 15.63021307075235 -7.771023542547438 24.74185596757632 0.8112936997596801 0.9858974699175096 0.2576362730704973 0.11706030669414105 222.65207331506372 574773.2102533005 0.06260858327515882 0.03069724770519571 1.694245955055417e-08 7.771023542547438 0.17460377015782946 RGSDASDFDLLET(ph)QSACSDTSESSAAGGQGNSR ddPTM_A459_Selumetinib_30min_R1 1 RGSDASDFDLLETQSACSDTSESSAAGGQGNSR 33 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 RGS(0.451)DAS(0.028)DFDLLET(0.48)QS(0.041)ACSDTSESSAAGGQGNSR 128.68 9.624199999999999e-25 12346000.0 397.14 327.47 383.19 492.37 363.52 344.24 439.07 337.86 159.42 324.72 True False 406.39258930008043 289.12966016332734 331.1549027120034 406.38682242958623 330.6396801846688 340.777258144912 405.9505964027151 328.89885527605236 270.5240964238821 366.4009750406505 1.109147128374844 0.7891072345843232 0.9038046437383614 1.1091313891413621 0.9023984724603581 0.9300664609506138 1.1079408190921893 0.8976473254187234 0.7383279926967135 1.0 8.517279532413838 -7.991660046956021 24.994347060240678 0.8521051869031934 0.9712458899238429 0.1319091969676216 0.11648661532622244 321.47567446926803 963443.6434108202 0.06217947738693763 0.029792989560783422 1.0193890238036767e-08 7.991660046956021 0.1191407030206495 RGSFDATGS(ph)GFSMTFSSSSYSSSGYGR ddPTM_A459_Selumetinib_30min_R1 1 RGSFDATGSGFSMTFSSSSYSSSGYGR 27 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 RGS(0.086)FDAT(0.185)GS(0.534)GFS(0.185)MT(0.009)FSSSSYSSSGYGR 69.99 0.00049185 65422000.0 1366.9 1388.1 1519.8 1142.3 1157.5 1221.8 1087.8 1111.3 853.27 1180.7 True False 1398.7461104756 1225.5806066898167 1313.4195076638298 942.8187486266768 1052.8043293732235 1209.5098013056397 1005.746370207195 1081.8247139888615 1447.9368696249276 1332.2543459919198 1.0499092119186704 0.9199298995548182 0.9858624305600845 0.7076867502539151 0.7902427434675516 0.9078670337570627 0.754920690056653 0.8120256595473121 1.0868321608265255 1.0 10.379653824031953 -5.646048972009009 20.17439732236372 0.8513937100682077 0.9787768193968203 0.18609946311175318 0.11159363680094604 3.5449024590706517 606.6247594482185 0.029919354399021783 0.05182184331091658 2.259181005596467e-06 5.646048972009009 0.12738310932861252 RGSGDT(ph)SSLIDPDTSLSELR ddPTM_A459_Selumetinib_30min_R2 2 RGSGDTSSLIDPDTSLSELR 20 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 RGS(0.018)GDT(0.665)S(0.029)S(0.288)LIDPDTSLSELR;RGS(0.089)GDT(0.304)S(0.304)S(0.304)LIDPDTSLSELR 209.85 1.0775e-14 102090000.0 21939.4 18027.6 22935.6 25225.0 26941.2 17214.6 20358.2 20896.7 16929.9 21704.2 True False 20720.0959783768 19410.25895212971 21459.94846639315 21789.311484447862 23556.60559861611 19585.75489142006 21304.896639008002 20957.5059373651 20316.35306092936 21077.543351716038 0.9830413171319543 0.9208975936253697 1.0181427744351421 1.0337690271040945 1.1176162803004381 0.9292237982670536 1.0107865173610688 0.9943049618094527 0.9638861949855885 1.0 14.363419106067676 -5.276275493705263 24.692122830915757 1.0103174755329372 0.9519694543386871 0.17993670944231843 0.04811474384999199 1020.8025994918543 1698947.776496809 0.012934761733511303 0.0271044570027227 5.293275596497667e-06 5.276275493705263 -0.05834802119425009 RGSGDTSSLIDPDT(ph)SLSELR ddPTM_A459_Selumetinib_30min_R2 2 RGSGDTSSLIDPDTSLSELR 20 1 C9JSU1;Q9Y608-4;Q9Y608;Q9Y608-2;Q9Y608-5 C9JSU1 LRRFIP2 Leucine-rich repeat flightless-interacting protein 2 1 RGSGDTSSLIDPDT(0.44)S(0.44)LS(0.12)ELR;RGSGDTSSLIDPDT(0.475)S(0.475)LS(0.05)ELR 79.586 0.0055358 3365700.0 13298.0 13430.0 16709.8 16234.4 17764.7 14078.2 12407.599999999999 13953.3 13913.7 16745.8 True False 12558.950396111768 14460.037815743754 15634.709660254624 14023.246714097948 15532.93956756698 16017.344260824535 12984.577985192976 13993.901792906841 16696.828781259952 16262.305243186405 0.7722736849607301 0.8891751568740375 0.9614079570179799 0.862316043414166 0.9551499209544714 0.9849368844884704 0.7984463328551323 0.8605115685409988 1.0267196766741051 1.0 13.989244158929315 -1.5228787454891621 0.054607413912763365 1.1404632293840216 0.456921217128954 0.251537180908349 0.0716434362785358 743.4439817158677 3.062234142431845 8.434538715737897 41.59622364347845 0.02999999998557491 1.5228787454891621 -0.6835420122550675 RGSGS(ph)PEDTPR ddPTM_A459_Selumetinib_30min_R2 3 RGSGSPEDTPR 11 1 Q96HP0 Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 RGS(0.241)GS(0.759)PEDTPR;RGS(0.03)GS(0.969)PEDT(0.001)PR;RGS(0.008)GS(0.91)PEDT(0.083)PR 118.73 0.0068948 24296500.0 39054.2 31066.4 35311.2 45673.0 48257.0 35192.3 35160.9 35105.6 32758.5 44615.1 True False 36883.72391034959 33449.09298577974 33039.31583592763 39452.25860968039 42194.52423694633 40039.719881108074 36795.951520001596 35207.751483955064 39311.1153489657 43326.946139048974 0.8512883366387933 0.7720159384977587 0.7625581486840707 0.9105709523829913 0.9738633344139149 0.9241297494775833 0.8492625213397804 0.8126063482748815 0.9073133200480993 1.0 15.402976932676308 -5.769016212705106 24.88917527816035 0.9038792080032038 0.7929603171923402 0.47524516813642315 0.055391771391176584 150.35629956838767 493907.67645817 0.016567269143656107 0.025116515668199998 1.7020949660751883e-06 5.769016212705106 -0.11091889081086359 RGSLPDTQPSQGPS(ph)TPKGER ddPTM_A459_Selumetinib_30min_R2 2 RGSLPDTQPSQGPSTPKGER 20 2 A0A494BYR6;Q86Y91-6;Q86Y91 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 1 RGSLPDTQPS(0.004)QGPS(0.498)T(0.498)PKGER;RGSLPDTQPS(0.001)QGPS(0.5)T(0.5)PKGER 77.137 0.0021156 4769900.0 31567.0 39600.0 34772.0 36289.0 38211.0 26424.7 21288.1 19667.9 16036.6 40654.0 True False 29812.63251271321 42637.19266593093 32534.807376891065 31346.375597983297 33410.592569325796 30064.462565456535 22278.0388315699 19725.13033280387 19244.36810004194 39480.21338822276 0.7551284543362307 1.079963581925571 0.8240788127704609 0.7939768534111864 0.8462617017995253 0.7615070939415183 0.5642836479251554 0.49962066159166263 0.4874433658907902 1.0 15.268842167046364 -7.029453160334777 2.6934211086545865 0.596564819546096 0.8672612310760889 0.28755924120828225 0.15860253262304663 0.29434392938138376 4.269456318769808 0.06321357982220485 0.04972934393602531 9.344301432768752e-08 7.029453160334777 0.2706964115299929 RGSQNSSEHRPPASSTSEDVKAS(ph)PSSANK ddPTM_A459_Selumetinib_30min_R2 1 RGSQNSSEHRPPASSTSEDVKASPSSANK 29 3 O15014 O15014 ZNF609 Zinc finger protein 609 1 RGS(0.003)QNS(0.001)S(0.001)EHRPPAS(0.027)S(0.027)T(0.027)S(0.068)EDVKAS(0.552)PS(0.248)S(0.047)ANK 44.304 0.031764999999999995 5086600.0 6280.6 7033.0 11083.0 13938.0 14268.0 8550.2 7312.6 7361.0 8251.2 14160.0 True False 5931.549395233839 7572.408485340711 10369.931846258014 12039.620355608897 12475.526282461618 9727.912439012234 7652.650389642011 7382.419291320845 9901.670557790674 13751.164007901662 0.4313488946699688 0.5506739997420925 0.7541130220175738 0.8755346346455266 0.9072342003406374 0.7074246539000192 0.5565092806139657 0.5368577734276733 0.720060538300685 1.0 13.747266124539493 -5.08667211643888 3.0944515553709815 0.7412283504529354 0.44379436639906944 0.3807569783526823 0.13825240259719282 0.31402818334876226 5.550790762510266 0.039685230732601766 0.1553798046744976 8.19082945835829e-06 5.08667211643888 -0.297433984053866 RGSS(ph)DPTVQR ddPTM_A459_Selumetinib_30min_R2 1 RGSSDPTVQR 10 1 Q2KHT3;A0A2R8YDG4;H7BZJ9;H7BZI2;Q2KHT3-2;H7BXG1 Q2KHT3;H7BXG1 CLEC16A Protein CLEC16A 1 RGS(0.285)S(0.712)DPT(0.003)VQR 126.5 0.0061883 1537400.0 9460.4 4468.0 6343.0 6857.7 6761.5 3640.6 7255.2 6182.3 4539.0 4971.0 True False 8934.628840981793 4810.681233115642 5934.898285736221 5923.669429807659 5912.0599214230615 4142.059603923643 7592.581175906068 6200.289469465139 5446.926830256435 4827.474313790899 1.850787442919742 0.996521352661104 1.229400282624329 1.227074251412421 1.224669368935588 0.8580179478305673 1.572785411662563 1.2843754448889446 1.12831813826454 1.0 12.237052867511741 -4.751220137977743 24.959382227639328 1.186244043468056 1.8507888365803875 0.5458570806963488 0.185962241584087 331.53819906245246 809690.0960229483 0.04553915679594703 0.6166451527891081 1.7732903962113943e-05 4.751220137977743 0.6645447931123316 RGSS(ph)GSVDETLFALPAASEPVIR ddPTM_A459_Selumetinib_30min_R1 1 RGSSGSVDETLFALPAASEPVIR 23 1 Q9NQC3-5;Q9NQC3 Q9NQC3-5 RTN4 Reticulon-4 1 RGS(0.258)S(0.371)GS(0.371)VDETLFALPAASEPVIR 108.73 9.0611e-06 5820100.0 1805.9 1915.1 1632.6 1538.5 1591.5 1812.7 1762.2 1902.7 1228.2 2148.9 True False 1847.973956330298 1690.8792016941634 1410.9018872298777 1269.829856221782 1447.549106002147 1794.465883799914 1629.275835244641 1852.2342151593696 2084.1656958211784 2424.732247058553 0.7621352660987943 0.6973467704507876 0.5818794586253576 0.5236990013071401 0.5969933825716928 0.7400676449850426 0.6719405151728065 0.7638922678602217 0.8595446768811209 1.0 11.243609730036912 -8.292911804988654 0.917558924816211 0.9993886054357772 0.6362224897177458 0.744256294884079 0.06738333923644003 0.29471325842664436 0.5283866230349676 0.07067487006010864 0.02529338938512222 5.0943431470033655e-09 8.292911804988654 -0.3631661157180315 RGSS(ph)PGSLEIPK ddPTM_A459_Selumetinib_30min_R2 1 RGSSPGSLEIPK 12 1 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 RGS(0.321)S(0.649)PGS(0.029)LEIPK 124.5 0.0015593 5886200.0 57915.0 46651.0 56858.0 57366.0 57576.0 50863.0 57315.0 56863.0 40347.0 56752.0 True False 54696.31615211413 50228.98169339251 53199.81818230963 49552.651838130274 50342.788144029284 57868.916561656944 59980.261067517946 57028.461915823624 48417.527389371324 55113.42230059566 0.9924318590450331 0.9113747540379041 0.9652788007275436 0.899103154361632 0.9134397038429818 1.0499967910907886 1.0883058711247857 1.0347472455037012 0.8785070018932218 1.0 15.750116094504321 -6.756544907374964 24.999905015256097 1.017357742648725 0.9344800785346326 0.29212896063178106 0.05702387081405097 151.16743427403205 772130.5622224271 0.019688687510315096 0.019091950825693486 1.751681295651207e-07 6.756544907374964 -0.08287766411409248 RGSSAAASPGS(ph)PPPGR ddPTM_A459_Selumetinib_30min_R1 6 RGSSAAASPGSPPPGR 16 1 Q86UX6 Q86UX6 STK32C Serine/threonine-protein kinase 32C 1 RGSSAAAS(0.001)PGS(0.999)PPPGR;RGS(0.012)S(0.012)AAAS(0.136)PGS(0.84)PPPGR;RGSSAAASPGS(1)PPPGR;RGSSAAASPGS(1)PPPGR;RGSSAAAS(0.001)PGS(0.999)PPPGR;RGSSAAASPGS(1)PPPGR 133.98 0.00025158 109416100.0 11169.23 12189.29 13304.73 14908.900000000001 13090.960000000001 10610.36 12905.28 10704.58 5612.639999999999 9197.279999999999 True False 11429.451327461687 10762.162260152816 11498.020743650599 12305.340489713957 11906.884979396702 10503.62941183607 11931.824339499466 10420.65976502375 9524.240148993462 10377.840477093721 1.1013323391016765 1.0370329245190637 1.1079396305068836 1.1857322837901267 1.1473374451725225 1.0121209161983162 1.1497405809846224 1.0041260306539248 0.9177477886671749 1.0 13.341218644331907 -7.924213879304955 5.062180877128495 0.9590299850588473 1.1039676686481839 0.5818912157180167 0.052081713540208754 0.14298940332763127 6.5425635539149605 0.031090706833990803 0.014272347454154058 1.1906554951963406e-08 7.924213879304955 0.14493768358933656 RGSSAAASPGS(ph)PPPGR ddPTM_A459_Selumetinib_30min_R2 6 RGSSAAASPGSPPPGR 16 1 Q86UX6 Q86UX6 STK32C Serine/threonine-protein kinase 32C 1 RGSSAAAS(0.003)PGS(0.997)PPPGR;RGS(0.003)S(0.003)AAAS(0.238)PGS(0.755)PPPGR;RGSSAAAS(0.044)PGS(0.956)PPPGR;RGSSAAAS(0.001)PGS(0.999)PPPGR;RGSSAAASPGS(1)PPPGR;RGSSAAAS(0.006)PGS(0.994)PPPGR 94.339 0.0047717 70472640.0 17644.72 18287.4 21271.42 19108.38 23099.25 16946.760000000002 18269.45 18007.61 14947.36 21334.600000000002 True False 16664.09709981061 19689.984776741054 19902.83999577096 16505.785680205903 20197.31570508491 19281.02236262951 19119.015625228403 18060.00916377969 17937.249664133466 20718.61466405217 0.804305566275319 0.9503523809873331 0.9606260031614652 0.7966645428685087 0.9748391015799074 0.9306134929997537 0.9227941122145029 0.8716803442999839 0.8657552618735407 1.0 14.338639920985186 -4.749828944658522 24.845761732136786 0.914912289949185 0.8043053010621314 0.2635730245733787 0.05723066020622608 704.5269930913424 1507550.9953435094 0.01390116075714476 0.2172874474561802 1.7789799579774883e-05 4.749828944658522 -0.11060698888705367 RGSSSS(ph)SPEHSASSDSTK ddPTM_A459_Selumetinib_30min_R2 1 RGSSSSSPEHSASSDSTK 18 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 RGS(0.305)S(0.063)S(0.168)S(0.454)S(0.01)PEHSASSDSTK 85.7 0.0038686 3583600.0 10593.0 6764.8 8031.2 13322.0 12913.0 9808.7 8798.2 15045.0 9719.9 17161.0 True False 10004.283467138823 7283.638407739637 7514.481335709404 11507.520618268174 11290.753496315308 11159.759390486686 9207.333733302561 15088.778459166171 11664.151596697408 16665.517340367252 0.6002984043529466 0.4370484431405674 0.4508999740144767 0.6904988536056204 0.6774919293364401 0.6696317409514491 0.5524781226563269 0.905389142803152 0.6998973604284383 1.0 14.024578482644033 -8.005013974618473 0.17378439497044287 1.1596929595316947 0.3298590682075893 0.653403569982272 0.09966541532280888 2.1762473444001222 0.3926903665861356 0.7734213758740117 0.7474104539497017 9.885212857561724e-09 8.005013974618473 -0.8298338913241055 RGSSSSS(ph)PEHSASSDSTK ddPTM_A459_Selumetinib_30min_R2 1 RGSSSSSPEHSASSDSTK 18 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 RGS(0.071)S(0.022)S(0.008)S(0.246)S(0.653)PEHS(0.001)ASSDSTK 77.1 0.0072126 3302700.0 6549.1 6437.4 6691.1 13027.0 12969.0 7997.1 9197.8 13022.0 9599.6 15819.0 True False 6185.127240124501 6931.127880496563 6260.601910718848 11252.70012717156 11339.71827566896 9098.627934554126 9625.515925094938 13059.891864091845 11519.788235234562 15362.264367301997 0.40261820082261524 0.4511787920568018 0.4075311920841763 0.7324896810865011 0.7381540900835637 0.5922712770078488 0.6265688244229468 0.8501280509069571 0.749875666750925 1.0 13.907103261670121 -5.63586592711878 0.17392093404439835 1.0667604536914184 1.1192159688270312e-13 0.7737252367583177 0.08902327205188376 6.8180953726051685 0.29964509019040025 0.3586481995380074 1.7067968203062176 2.312778667634892e-06 5.63586592711878 -1.0667604536913065 down RGT(ph)GQSDDSDIWDDTALIK ddPTM_A459_Selumetinib_30min_R1 2 RGTGQSDDSDIWDDTALIK 19 1 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 RGT(0.604)GQS(0.328)DDS(0.069)DIWDDTALIK;RGT(0.496)GQS(0.496)DDS(0.008)DIWDDTALIK 100.14 0.0016215 68626100.0 5922.0 5884.400000000001 8411.7 9251.7 7067.9 6224.200000000001 5814.040000000001 5412.139999999999 3083.96 4698.51 True False 6059.971077793913 5195.45171241666 7269.437342160703 7636.064270917812 6428.609692939093 6161.590199121435 5375.482281889544 5268.592466091674 5233.25487647344 5301.609525863043 1.1430436451857358 0.9799763047564122 1.3711755471046918 1.4403294383840435 1.212576984702129 1.1622112434088394 1.0139340243120742 0.9937722573474527 0.9871068117981632 1.0 12.372214701407083 -7.15675288397815 2.408947531752115 0.9924461551545178 1.234100696826753 0.470404220741117 0.11606145052823516 0.3090547563162813 3.504949092976031 0.0588812770302404 0.04203088893054459 6.970230113397698e-08 7.15675288397815 0.2416545416722351 RGT(ph)SLMEDDEEPIVEDVMMSSEGR ddPTM_A459_Selumetinib_30min_R1 4 RGTSLMEDDEEPIVEDVMMSSEGR 24 1 Q8N3U4;Q8N3U4-2 Q8N3U4 STAG2 Cohesin subunit SA-2 1 RGT(0.5)S(0.5)LMEDDEEPIVEDVMMSSEGR;RGT(0.5)S(0.5)LMEDDEEPIVEDVMMSSEGR;RGT(0.5)S(0.5)LMEDDEEPIVEDVMMSSEGR;RGT(0.5)S(0.5)LMEDDEEPIVEDVMMSSEGR 144.08 1.314e-08 11455400.0 724.98 976.6699999999998 1000.05 1284.32 1273.72 697.33 1052.3200000000002 998.71 283.391 667.537 True False 741.8706234344868 862.3210223584356 864.2487028814398 1060.0376216722511 1158.5122508935303 690.3154933249813 972.9426551723074 972.2209665327243 480.8938289402864 753.2218763110083 0.9849297355354102 1.1448433051118392 1.1474025517078692 1.4073378044513374 1.538075681720078 0.9164835953861055 1.291707909410979 1.2907497738837455 0.638449099879467 1.0 9.556931091462234 -8.25159040373256 24.908510312744486 0.8192245412842656 1.2203480729796854 0.40378531913380644 0.19238025750411844 568.0949666636054 1436747.4897109047 0.1350780471294228 0.049672223474137696 5.602857748560835e-09 8.25159040373256 0.4011235316954198 RGTGQS(ph)DDSDIWDDTALIK ddPTM_A459_Selumetinib_30min_R1 1 RGTGQSDDSDIWDDTALIK 19 1 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 RGT(0.26)GQS(0.726)DDS(0.014)DIWDDTALIK 105.65 0.0004388999999999999 4281300.0 1952.7 1620.2 2580.9 3030.8 2172.4 1941.4 1746.4 1808.7 1018.5 1316.9 True False 1998.194110707223 1430.5062307894543 2230.427955868915 2501.527675162155 1975.9068035683702 1921.8712786501628 1614.6676419652931 1760.7274005144013 1728.3201117032002 1485.936942692266 1.3447368143945824 0.9626964574940975 1.5010246342134528 1.6834682571588877 1.3297379900848025 1.2933733750289953 1.086632679741974 1.1849274016461704 1.163118071869037 1.0 10.537157179545737 -7.090244229145173 3.05313578721926 1.1236721839349628 1.3655629007683179 0.3216338228329978 0.17498801561545457 0.38788453147221164 6.970122343802125 0.07891522094748858 0.06038369660811461 8.123735426080387e-08 7.090244229145173 0.24189071683335506 RGTGQSDDS(ph)DIWDDTALIK ddPTM_A459_Selumetinib_30min_R1 1 RGTGQSDDSDIWDDTALIK 19 1 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 RGT(0.151)GQS(0.129)DDS(0.72)DIWDDTALIK 53.089 0.034962 64203000.0 4557.1 4559.7 6242.3 6552.5 5876.4 4447.2 4276.3 4475.4 2501.5 3580.7 True False 4663.27156342699 4025.848204252981 5394.629946499485 5408.228880658583 5344.880657562687 4402.465205734527 3953.7352481311204 4356.697853852023 4244.862797668685 4040.3177239715947 1.1541843691547697 0.9964187173615667 1.3351994360474737 1.338565244156676 1.322886223984563 1.0896334166034212 0.9785703794217043 1.0783057550160757 1.050625987279046 1.0 11.980253033276444 -6.9361694428958645 6.351511970343553 1.0333630722306608 1.2277398216568154 0.48646596876690584 0.09916122508536651 0.20748042737906702 15.703724828847644 0.039411077877953726 0.03461954869101887 1.158325339606258e-07 6.9361694428958645 0.19437674942615457 RGTGQSDDS(ph)DIWDDTALIK ddPTM_A459_Selumetinib_30min_R2 1 RGTGQSDDSDIWDDTALIK 19 1 B4DP61;A0A1W2PRV5;E7EQZ4;Q16637-4;Q16637-2;Q16637-3;Q16637 B4DP61 SMN2;SMN1 Survival motor neuron protein 1 RGT(0.005)GQS(0.005)DDS(0.989)DIWDDT(0.001)ALIK 73.404 0.005760899999999999 8448400.0 23595.0 23384.0 27201.0 28358.0 29008.0 17221.0 19516.0 20235.0 17441.0 22618.0 True False 22283.68435826871 25177.47760858913 25450.917274209525 24495.591479721414 25363.755705189695 19593.036433326666 20423.53267022035 20293.88049991542 20929.687342256537 21964.959571378502 1.0145106020274912 1.1462564967065412 1.1587054003674748 1.1152122270072584 1.154737190513203 0.8920133164668977 0.9298233672523253 0.9239206853064011 0.9528671006309987 1.0 14.422916223563533 -6.759734387131742 24.999999984135748 0.9343510789593777 1.1215800092339538 0.7889884580619482 0.04600593742575821 19.18922112704053 281370.06334882404 0.015316222270220751 0.014562423777474336 1.7388639862648213e-07 6.759734387131742 0.1872289302745761 RGTLVAER ddPTM_A459_Selumetinib_30min_R2 1 RGTLVAER 8 1 A0A087WW53;F5H390;Q9BR76 A0A087WW53 CORO1B Coronin;Coronin-1B 0 109.66 0.013625 0.0 4881.9 3245.0 2881.2 4363.7 5281.7 3395.1 3484.9 4432.2 3708.1 4233.7 False True 4610.583541794109 3493.8810656804517 2695.8267288133716 3769.356532197629 4618.165627002908 3862.744207350755 3646.9547551983464 4445.096968209791 4449.823612970671 4111.462080526357 1.1213975591874736 0.8497904145167645 0.6556856602379869 0.9167922404175668 1.1232416927487952 0.9395062222868026 0.887021376768105 1.0811475045005698 1.082297130757192 1.0 12.005435807821806 -6.0087586077125845 24.937306068493413 1.0130614099142747 0.8585741166149942 0.217478272003362 0.12383581597177855 613.5927395091064 1747017.014022664 0.03694252638749783 0.05180951409102102 9.800345630173534e-07 6.0087586077125845 -0.15448729329928057 RHAPS(ph)PEPAVQGTGVAGVPEESGDAAAIPAK ddPTM_A459_Selumetinib_30min_R2 1 RHAPSPEPAVQGTGVAGVPEESGDAAAIPAK 31 1 P13051 P13051 UNG Uracil-DNA glycosylase 1 RHAPS(0.974)PEPAVQGT(0.026)GVAGVPEESGDAAAIPAK 55.158 0.0024941 4233400.0 10211.0 9051.7 11739.0 14259.0 12268.0 8946.1 8721.7 10167.0 8117.3 8729.3 True False 9643.513497871656 9745.936284197156 10983.725520456806 12316.899601853012 10726.784162688467 10178.34407038985 9127.276331720685 10196.584286762542 9740.98681631208 8477.262427554793 1.137574019948473 1.1496560791274575 1.295668927831574 1.4529336218043372 1.265359454701054 1.2006640300889826 1.0766773365483016 1.2028156936158074 1.1490722269785623 1.0 13.049382733433152 -6.994477386039966 3.7188418436666493 1.1243643052034675 1.265841767931156 0.35844716539273125 0.09516308261568762 0.3060186844679205 9.287867011352995 0.04000121962133463 0.03292371399332694 1.0127974843810728e-07 6.994477386039966 0.14147746272768846 RHGAPAAPS(ph)PPPR ddPTM_A459_Selumetinib_30min_R1 4 RHGAPAAPSPPPR 13 1 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 RHGAPAAPS(1)PPPR;RHGAPAAPS(1)PPPR;RHGAPAAPS(1)PPPR;RHGAPAAPS(1)PPPR 102.15 0.0048939 112256000.0 3710.1400000000003 4720.32 5202.28 5866.999999999999 5817.200000000001 4729.900000000001 4956.18 4776.85 3226.37 4055.9100000000003 True False 3796.5790433242682 4167.662739982769 4495.838950078553 4842.438587229894 5291.035287110076 4682.32150040559 4582.331352356593 4650.152420604425 5474.9142452585675 4576.525556408979 0.8295767163383427 0.9106608689525097 0.9823694623058682 1.0581036918822686 1.156124929686123 1.0231170879945057 1.0012686034145453 1.0160879390463227 1.1963036538912106 1.0 12.16003702167511 -5.25113227881153 1.599676929513516 1.0645321556496818 0.8282404495964732 0.6136609283940615 0.06259076529791271 0.34526017906918943 1.4549414698104195 0.01883651109763038 0.09537370088139238 5.608771162554405e-06 5.25113227881153 -0.2362917060532086 RHGAPAAPS(ph)PPPR ddPTM_A459_Selumetinib_30min_R2 2 RHGAPAAPSPPPR 13 1 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 RHGAPAAPS(1)PPPR;RHGAPAAPS(1)PPPR 78.22800000000002 0.021316 28534600.0 12237.5 12616.2 15994.8 21535.9 24491.1 13866.900000000001 10366.0 14942.2 14874.5 19107.1 True False 11557.388740593917 13583.821972523181 14965.711981821494 18602.67326850034 21414.30906478803 15776.939603814963 10848.039539839321 14985.679328185619 17849.815628254968 18555.428376792217 0.6228575544528554 0.7320672795413788 0.8065409042530929 1.0025461493396302 1.1540724703274161 0.8502600577816686 0.5846288923950288 0.8076169961631615 0.9619727050106923 1.0 14.179553687507003 -5.212483475460719 2.2660354355445214 0.8939060723337557 0.6413116747839522 0.29414898587591565 0.14315270446156994 0.5128162638039422 4.824118562607088 0.044482075374132714 0.1756329545379421 6.13079118850184e-06 5.212483475460719 -0.2525943975498035 RHNSWSSS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 RHNSWSSSSR 10 1 H3BQ37;H3BPW9;Q96F86 H3BQ37 EDC3 Enhancer of mRNA-decapping protein 3 1 RHNS(0.011)WS(0.065)S(0.215)S(0.67)S(0.039)R 78.28699999999998 0.027158 8459500.0 2497.2 1001.7 2637.4 2187.0 2757.3 2745.5 3150.0 3322.8 2943.4 4246.9 True False 2358.4156210836472 1078.5271690268437 2467.7125553840015 1889.1268272145678 2410.903323425245 3123.6677038324315 3296.4812416065856 3332.468797880848 3532.162245467459 4124.280962228639 0.5718367983856342 0.2615067156928222 0.5983376443030989 0.4580499836252038 0.5845633082481522 0.7573847980872027 0.7992862930039726 0.8080120700797457 0.8564310428450499 1.0 12.00992690277229 -6.928250423264685 0.5427054442819493 0.9591919481582645 0.397131979181812 0.8000119477752043 0.09174836988455316 0.37752516519931517 0.23815300692070318 0.0782257222670767 0.0831788126441802 1.1796402343182593e-07 6.928250423264685 -0.5620599689764525 RHPPDDDLSQDSPEQEAS(ph)KSPR ddPTM_A459_Selumetinib_30min_R2 2 RHPPDDDLSQDSPEQEASKSPR 22 2 Q9P0K8-2;Q9P0K8 Q9P0K8-2 FOXJ2 Forkhead box protein J2 1 RHPPDDDLS(0.001)QDS(0.008)PEQEAS(0.496)KS(0.496)PR;RHPPDDDLSQDSPEQEAS(0.747)KS(0.253)PR 69.975 0.0017029 10944900.0 22056.0 23264.0 24004.0 25460.0 24453.0 19632.5 17670.1 22738.6 17414.0 22826.2 True False 20830.21581716359 25048.273994449934 22459.60877357911 21992.304079050267 21380.995527406365 22336.698668909212 18491.79466263889 22804.765561422133 20897.28658781352 22167.148296409956 0.9396885670015169 1.1299727713964265 1.0131934190748622 0.9921124623238974 0.9645352321150433 1.0076487227960989 0.8341981753978567 1.0287640636714395 0.9427142503123825 1.0 14.436135565485442 -5.903438487837734 2.06869792342559 0.9598478544043135 1.0400671981080132 0.1600406404136232 0.06578110406795776 0.4996603957814034 4.346464247557969 0.019839445454166046 0.03393636850161357 1.2489973362834669e-06 5.903438487837734 0.08021934370369965 RHS(ph)DENDGGQPHKR ddPTM_A459_Selumetinib_30min_R2 1 RHSDENDGGQPHKR 14 2 F2Z2T1;Q09161 F2Z2T1 NCBP1 Nuclear cap-binding protein subunit 1 1 RHS(1)DENDGGQPHKR 64.12100000000001 0.03077 523330.0 0.0 0.0 538.55 494.28 814.38 0.0 724.64 2489.7 482.34 920.07 True False 0.0 0.0 503.90027932890473 426.9582113194409 712.0703037504262 0.0 758.3371958469191 2496.9446148079764 578.8214777056372 893.5051884710509 0.0 0.0 0.5639589851640026 0.47784637048391815 0.7969403120858284 0.0 0.848721647766334 2.7945496534616665 0.6478098674458797 1.0 9.803332296612528 -7.529653052843288 24.97048467902728 1.5970351918121484 0.3418209412051361 0.4515090682769668 0.5759363818881521 136.12646540730174 501760.7419660617 0.2541757585007708 0.1471863242706702 2.953567816957901e-08 7.529653052843288 -1.2552142506070123 RHS(ph)EQVANGPTPPPR ddPTM_A459_Selumetinib_30min_R2 1 RHSEQVANGPTPPPR 15 1 A6ND36;A6ND36-2;K7EKG0 A6ND36 FAM83G Protein FAM83G 1 RHS(1)EQVANGPTPPPR 76.85 0.018479 3058200.0 4447.7 3527.4 4775.5 4370.4 5189.6 3718.8 2766.0 3607.9 3327.1 4081.9 True False 4200.514639553793 3797.9402376213343 4468.249529171268 3775.1439806394833 4537.636052387357 4231.030944094722 2894.6244807250223 3618.398391680004 3992.612966941218 3964.044940950124 1.0596536371625975 0.9580971694813892 1.1271944682091048 0.9523464130390601 1.1446984380807126 1.0673519112728842 0.7302198950426689 0.9128045835960493 1.0072067866072796 1.0 11.952757603321288 RHS(ph)FTSLTMANK ddPTM_A459_Selumetinib_30min_R2 2 RHSFTSLTMANK 12 1 Q7Z6J0;Q7Z6J0-3;H0YA90 Q7Z6J0 SH3RF1 E3 ubiquitin-protein ligase SH3RF1 1 RHS(0.918)FT(0.08)S(0.001)LTMANK;RHS(0.944)FT(0.055)S(0.001)LTMANK 109.55 0.0038972 21806900.0 157959.0 132952.0 165280.0 228399.0 248380.0 167700.0 163195.0 178191.0 176046.0 173960.0 True False 149180.2711399773 143148.99089194075 154646.06474325797 197290.6621897487 217176.2838546269 190799.15277097045 170783.8908647579 178709.50630889175 211260.11913622427 168937.3227976391 0.8830509958931473 0.8473497065145942 0.9154049690280706 1.167833483581793 1.2855435392140708 1.1294079343231838 1.010930492069717 1.0578450241155901 1.2505236595307088 1.0 17.366128567920562 -5.689172280739045 5.033149726783693 1.1328479405701521 0.8706496234991816 0.6232521964821094 0.08826626703549414 0.1359337290725482 6.313528720844478 0.025660429192144188 0.044849005694271325 2.045632991426222e-06 5.689172280739045 -0.2621983170709705 RHS(ph)GSYLVTSV ddPTM_A459_Selumetinib_30min_R2 2 RHSGSYLVTSV 11 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 RHS(0.78)GS(0.22)YLVTSV;RHS(0.492)GS(0.492)Y(0.016)LVTSV 93.649 0.011962 6950500.0 25456.0 26627.0 31156.0 40019.0 41042.0 30397.0 26918.0 29878.0 28692.0 37398.0 True False 24041.257428441964 28669.205280700582 29151.45688008793 34568.34316337441 35885.9370398647 34583.910833507354 28169.7403370051 29964.940033430827 34431.201721462356 36318.22256832671 0.6619612890804975 0.7893889968531425 0.8026674990838085 0.951818143036593 0.9880972829094613 0.9522467892927157 0.7756365357365275 0.8250662591501212 0.9480420374836837 1.0 15.148405977701174 -5.101660479148663 1.4554066487872253 0.9085899860728269 0.6487678908173058 0.5614927909144398 0.07120687868008523 0.5798310221780792 1.7021542762944253 0.0229605937396277 0.18443452108822164 7.912970029827586e-06 5.101660479148663 -0.25982209525552113 RHS(ph)IAIGEVPACR ddPTM_A459_Selumetinib_30min_R1 2 RHSIAIGEVPACR 13 1 Q8WUY9-2;Q8WUY9 Q8WUY9-2 DEPDC1B DEP domain-containing protein 1B 1 RHS(1)IAIGEVPACR;RHS(1)IAIGEVPACR 115.2 0.0020796 17481700.0 2635.19 2968.3 3100.8999999999996 3143.1000000000004 2707.01 2707.7 2970.0 2527.24 1858.75 2239.82 True False 2696.5847998128565 2620.770056074766 2679.814812024454 2594.2165882942368 2462.1614234614344 2680.462996394894 2745.970508839282 2460.2093855675434 3154.1629922713023 2527.3227146943505 1.066972881672128 1.0369748354007562 1.0603374062376303 1.0264682753852337 0.9742172652293055 1.0605938769948753 1.0865136030605314 0.9734448914115332 1.2480254199166492 1.0 11.30339417892615 -8.231581291395269 24.989882821893012 1.1240129773508274 1.0367224845675898 0.2236508707768302 0.06579988014227796 830.2061929893306 694847.8553081072 0.0408999528223024 0.015454496056740211 5.867035399632644e-09 8.231581291395269 -0.08729049278323764 RHS(ph)LEVR ddPTM_A459_Selumetinib_30min_R1 1 RHSLEVR 7 1 Q96P66 Q96P66 GPR101 Probable G-protein coupled receptor 101 1 RHS(1)LEVR 102.77 0.034232 4416600.0 2161.6 2816.7 3405.5 3848.4 3125.4 2739.6 2756.3 2769.3 1417.3 2238.1 True False 2211.9610742585814 2486.919454551696 2943.0518050724904 3176.3491834149518 2842.7081218341878 2712.042111357778 2548.3900718901377 2695.849168045852 2405.054584503628 2525.3819359401314 0.8758916989065767 0.9847696378749472 1.1653887925577768 1.2577698201648388 1.1256547302322903 1.0739136416401736 1.0091107549406941 1.0675015646860007 0.9523528105891402 1.0 11.302285880612484 -7.187560179331738 3.8879494228446725 1.0123386011705575 1.0915780929710928 0.11055191071708659 0.09951663975906173 0.6019233374371558 17.593659339939506 0.04523404622411518 0.03371761181595464 6.492916542755312e-08 7.187560179331738 0.07923949180053524 RHS(ph)MREEDFIQPSSR ddPTM_A459_Selumetinib_30min_R2 1 RHSMREEDFIQPSSR 15 2 Q14289 Q14289 PTK2B Protein-tyrosine kinase 2-beta 1 RHS(1)MREEDFIQPSSR 54.094 0.042055 3819800.0 14174.0 15944.0 13577.0 17501.0 15316.0 12892.0 11313.0 10445.0 9406.8 15306.0 True False 13386.265823017628 17166.853531959663 12703.470601519895 15117.333609091073 13391.867153222744 14667.755978076024 11839.076916284223 10475.39322073717 11288.422847952465 14864.076010236075 0.9005784021690444 1.154922345670043 0.8546424677034558 1.0170382335693515 0.9009552389264223 0.9867923151075886 0.7964892609625582 0.7047456709400128 0.7594432940317815 1.0 13.859542163892762 -7.265971967309128 22.60867874198696 0.7905649754891655 0.9714702501828999 0.3274470020082517 0.10575645162019898 101.98772831658947 508708.9708086029 0.04091825412773044 0.028716666133983222 5.420358764178335e-08 7.265971967309128 0.1809052746937344 RHS(ph)PPIEK ddPTM_A459_Selumetinib_30min_R1 1 RHSPPIEK 8 1 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 RHS(1)PPIEK 69.815 0.037495 18355000.0 4511.3 5666.5 6055.7 6294.2 6115.6 6398.2 5022.0 5247.9 4395.6 4933.9 True False 4616.404512538277 5003.06354571562 5233.369201579059 5195.036126767074 5562.4450597968735 6333.839917100791 4643.1864967646015 5108.708644418384 7459.0121580781415 5567.214125255805 0.8292126741804027 0.8986655503367651 0.9400337554536927 0.9331482515105112 0.9991433659004966 1.137703665531234 0.8340233359627163 0.9176418455404115 1.3398105390342627 1.0 12.442739857627615 -3.0143385573544093 0.282520457182146 1.0673468564219053 0.22997707306100848 0.25259191665991176 0.12627918169154345 35.87736964575773 1.0616815986254242 0.14519253043444533 12.54291703019132 0.0009675233225060842 3.0143385573544093 -0.8373697833608968 RHS(ph)PPIEK ddPTM_A459_Selumetinib_30min_R2 3 RHSPPIEK 8 1 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 RHS(1)PPIEK;RHS(1)PPIEK;RHS(1)PPIEK 82.494 0.021141 50935000.0 110449.0 104937.0 93519.0 111436.0 109095.0 75463.0 107325.0 130658.0 84547.0 118253.0 True False 104310.68674237857 112985.3304743633 87502.08935578847 96258.2245621779 95389.51077832552 85857.34326509075 112315.82516045294 131038.19314840375 101458.76244055745 114838.72863180736 0.9083232458695751 0.9838608614051592 0.7619562703130854 0.8382035025030472 0.8306388612517702 0.747634045482723 0.9780309003642553 1.1410627295303368 0.8834890776773715 1.0 16.809249738249022 -7.447735250224966 7.259343834179613 1.019015148712882 0.8473312432281281 0.4421164628571006 0.08579461342048109 0.24204367328885337 20.441762420312447 0.03657934951112509 0.024442609682027126 3.5666849545055933e-08 7.447735250224966 -0.17168390548475387 RHS(ph)SETFSSTPSATR ddPTM_A459_Selumetinib_30min_R1 2 RHSSETFSSTPSATR 15 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 RHS(0.865)S(0.131)ET(0.004)FSSTPSATR;RHS(0.497)S(0.497)ET(0.004)FSSTPSATR 85.087 0.010822 12340400.0 1320.6100000000001 1440.42 1562.18 1522.98 1674.4 1321.73 1566.45 1727.48 938.0799999999999 1244.53 True False 1351.3776435402608 1271.7749567669089 1350.0445364405055 1257.0201328753008 1522.9508156393301 1308.434596234821 1448.291415343869 1681.6616187541424 1591.8532453476057 1404.2775482487696 0.9623294520556291 0.9056435875891482 0.9613801332394039 0.8951365308395702 1.084508413268128 0.9317492812347022 1.0313427122366143 1.1975279536807306 1.1335745183227888 1.0 10.455612389755608 -7.5369083695518455 5.335205383928639 1.124068876513427 0.959033310746109 0.513915777224158 0.06664959806239092 0.12726746287427718 11.194530065910174 0.030571516860591615 0.018047695537937614 2.904635429854936e-08 7.5369083695518455 -0.16503556576731804 RHS(ph)SETFSSTPSATR ddPTM_A459_Selumetinib_30min_R2 2 RHSSETFSSTPSATR 15 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 RHS(0.99)S(0.009)ET(0.001)FSSTPSATR;RHS(0.617)S(0.382)ET(0.001)FSSTPSATR 107.98 0.002108 6121700.0 3303.6 5269.530000000001 6911.5 7863.0 8882.0 3824.81 4286.05 4620.46 4515.7 7873.400000000001 True False 3119.9991373586145 5673.68600679048 6466.8216146722225 6792.045835568427 7766.163753912536 4351.642859331756 4485.359817646954 4633.904773641669 5418.9661792000425 7646.074484450069 0.4080524122154187 0.7420390709414533 0.8457701566763298 0.8883049530032054 1.015706003087819 0.5691342489772699 0.5866225638749524 0.6060501742515989 0.7087252668307995 1.0 12.900503538957501 -4.763569018335451 5.43701149898379 0.7636703447613585 0.3906773059497618 0.3342020492473816 0.15450446768846424 0.20078070845230217 18.412232819372353 0.041677212777317535 0.2823687459938797 1.7235781572024138e-05 4.763569018335451 -0.37299303881159673 RHS(ph)VSEMTSCPEPQGFSDPPGQGPTGTFR ddPTM_A459_Selumetinib_30min_R2 2 RHSVSEMTSCPEPQGFSDPPGQGPTGTFR 29 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 RHS(0.295)VS(0.248)EMT(0.21)S(0.21)CPEPQGFS(0.036)DPPGQGPTGTFR;RHS(0.537)VS(0.264)EMT(0.1)S(0.1)CPEPQGFSDPPGQGPTGTFR 74.498 3.4136999999999995e-05 10860900.0 9405.8 7082.8 9862.2 10426.6 10567.7 10125.9 5117.9 8339.0 9096.4 9218.7 True False 8883.063290400674 7626.02798520848 9227.676789151476 9006.479093111759 9240.09104956333 11520.650811231779 5355.892490926459 8363.265109404238 10915.934174651826 8952.532177940891 0.9922403085340046 0.8518291622563582 1.0307337193256387 1.0060258834147273 1.0321203952029334 1.2868594697284363 0.5982544809080295 0.9341787265519568 1.2193124758097795 1.0 13.128080083672542 -5.283481485215066 24.014396646483384 1.0064248016673618 0.9220346932346044 0.04055309213281644 0.1751963325374421 1762.8106442501792 1920543.3493842576 0.04671843101517779 0.09740694901851216 5.2061720321222595e-06 5.283481485215066 -0.0843901084327574 RHS(ph)VTLPSSK ddPTM_A459_Selumetinib_30min_R2 2 RHSVTLPSSK 10 1 G3V2D5;G3V515;G3V2P5;Q07352 G3V2D5 ZFP36L1 Zinc finger protein 36, C3H1 type-like 1 1 RHS(0.99)VT(0.01)LPSSK;RHS(0.992)VT(0.008)LPSSK 86.738 0.017782 38772000.0 233830.0 180872.0 233768.0 250247.0 242632.0 162727.0 159969.0 200726.0 167999.0 196094.0 True False 220834.66469565494 194744.300804855 218727.62138735357 216162.9268998467 212150.39900239874 185141.16716136955 167407.87547255983 201310.079428022 201603.4942842586 190432.25670660104 1.159649465457393 1.0226434542804244 1.1485849360297569 1.1351171836024025 1.1140465521513976 0.9722153712992885 0.8790941113011391 1.0571217445486687 1.0586625279291264 1.0 17.53891834724803 -6.756524965825811 24.813835278935922 0.989843562902392 1.1136928202693324 0.5241918426042855 0.05832696088522298 96.03135636223725 484880.4311407693 0.020490034307925606 0.01987244599026477 1.7517617296472552e-07 6.756524965825811 0.12384925736694041 RHS(ph)VVAGGGGGEGR ddPTM_A459_Selumetinib_30min_R2 1 RHSVVAGGGGGEGR 14 1 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 RHS(1)VVAGGGGGEGR 64.83 0.03788 1819500.0 2183.3 821.04 2267.5 2187.6 868.4 2077.6 1933.8 2307.8 1967.9 2817.7 True False 2061.9609264423852 884.0111279403011 2121.6115186673314 1889.6451061795115 759.3038284054998 2363.770541424972 2023.7255317520053 2314.5153159231436 2361.534987720122 2736.345679736194 0.7535454828357706 0.3230626651036016 0.7753448456380233 0.6905725106930527 0.2774882698587639 0.8638420792115924 0.7395723233137375 0.8458417125669158 0.8630250940911066 1.0 11.418034780579987 -6.848769796811664 24.999999999631136 0.8451460432801503 0.569338526719103 0.4476950233565755 0.16513443413631682 22.269622253450912 6370.672398062285 0.056499473152385585 0.04982786285502883 1.4165444379784455e-07 6.848769796811664 -0.2758075165610473 RHSS(ph)ETFSSTPSATR ddPTM_A459_Selumetinib_30min_R1 1 RHSSETFSSTPSATR 15 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 RHS(0.121)S(0.75)ET(0.121)FS(0.004)S(0.001)T(0.001)PSATR 67.43 0.030972000000000006 6371100.0 517.53 577.9 650.55 742.49 919.52 476.37 796.51 642.21 149.33 450.92 True False 529.5874420619188 510.2391993415786 562.2088832153601 612.8280597634778 836.3495783544412 471.5781503093533 736.4286094261204 625.176504607925 253.40210336832484 508.79997433274883 1.0408558741702592 1.0028286656474723 1.1049703450804078 1.2044577253903237 1.643768908304777 0.9268438956346077 1.4473833462587897 1.2287274688403726 0.4980387502979767 1.0 8.990954787617872 -8.242134648044201 24.573603888591727 0.749019386824483 1.204325416009911 0.37897571240001726 0.2308585011912303 574.8961545363314 731806.518416319 0.15455424047427463 0.05820854767866428 5.726184696449636e-09 8.242134648044201 0.45530602918542806 RHSS(ph)ETFSSTPSATR ddPTM_A459_Selumetinib_30min_R2 1 RHSSETFSSTPSATR 15 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 RHS(0.183)S(0.794)ET(0.022)FSSTPSATR 75.548 0.019748 1834800.0 2322.2 3827.7 3662.4 2873.9 4968.9 2654.5 2027.4 2504.7 2306.8 3771.7 True False 2193.1414205031406 4121.272282004641 3426.7651713196205 2482.4698622459773 4344.662359470388 3020.133279848187 2121.6781172168876 2511.988262324593 2768.2244573772955 3662.801220946518 0.5987606993142813 1.1251695173727303 0.935558596989355 0.6777517294821894 1.1861583791728856 0.8245419550962537 0.5792501392332224 0.6858106980961038 0.7557670456006751 1.0 11.83873169323348 -7.001451828350073 24.991933836704046 0.7251490135911308 0.9159688373980464 0.10864798361053474 0.1933478673936486 95.30270753858125 1640579.786360567 0.06596899479367738 0.0573749685913723 9.96662623147422e-08 7.001451828350073 0.19081982380691553 RHSVS(ph)EMTSCPEPQGFSDPPGQGPTGTFR ddPTM_A459_Selumetinib_30min_R2 1 RHSVSEMTSCPEPQGFSDPPGQGPTGTFR 29 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 RHS(0.121)VS(0.49)EMT(0.194)S(0.194)CPEPQGFS(0.003)DPPGQGPTGTFR 63.042 0.00074343 6331800.0 2735.3 3143.2 3220.9 3332.3 4974.1 2402.8 2848.5 2824.1 3487.2 5297.9 True False 2583.2829762734655 3384.273333019045 3013.6708006507656 2878.4349914618674 4349.2090889818 2733.763889553294 2980.96089419567 2832.317663445075 4184.737440508977 5144.935861402694 0.5021020758787788 0.6577872735805828 0.5857547852557934 0.5594695578337303 0.8453378635114899 0.5313504314139248 0.5793970954154816 0.5505059226672038 0.8133701863813064 1.0 12.328937376744785 -8.502000972673226 3.4439572108986862 0.9986951309723805 0.6072209413443087 0.6638396747464866 0.09149012732090722 0.1224716156980411 3.5559469864448503 0.08727038151352609 0.023072923444983476 3.147741264214184e-09 8.502000972673226 -0.3914741896280718 RHVTLPS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 RHVTLPSSPR 10 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 RHVT(0.004)LPS(0.498)S(0.498)PR 73.082 0.034021 3918900.0 1430.4 1560.6 1716.8 1908.0 2447.0 1687.8 1890.3 1771.9 638.63 1187.1 True False 1463.7255369261077 1377.8842264967427 1483.6679897073714 1574.8036175958132 2225.6692820529374 1670.8222643997874 1747.713149110739 1724.9034560576479 1083.7084663102742 1339.4758483331977 1.0927599319894588 1.0286741849144494 1.1076481830960982 1.1756864594127994 1.661597172373426 1.2473702056508946 1.3047739168164467 1.2877450968631232 0.8090541293886018 1.0 10.387452853297363 -8.256294755668584 24.833410030166256 0.904527053186828 1.2414838592342263 0.3800849698347907 0.17045639329134565 403.9693210995145 1950011.2560846116 0.13465515357569668 0.04737772107799513 5.542494161925336e-09 8.256294755668584 0.3369568060473983 RHVTLPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 RHVTLPSSPR 10 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 RHVTLPS(0.5)S(0.5)PR 79.48899999999998 0.025631 5656900.0 9662.7 6030.3 11969.0 15738.0 14733.0 10625.0 10183.0 11879.0 10295.0 11988.0 True False 9125.685816852856 6492.804619529381 11198.927570861877 13594.457250435706 12882.108825308876 12088.497305853078 10656.5296772317 11913.565923325692 12354.287666333987 11641.875291435392 0.7838673399608028 0.5577112326831021 0.9619522019017521 1.1677205699357367 1.1065321095464655 1.0383634082342605 0.9153619507564573 1.0233373597542463 1.061193953470941 1.0 13.507035848082708 -5.393975330105147 5.05719103457069 1.043897682755593 0.6746728245830005 0.7682158667203154 0.08076740323039634 0.09782469766762125 3.5665096375958325 0.021997665673018276 0.04722281613997559 4.036683225065454e-06 5.393975330105147 -0.36922485817259254 RIDFIPVS(ph)PAPSPTR ddPTM_A459_Selumetinib_30min_R1 1 RIDFIPVSPAPSPTR 15 1 Q96E09 Q96E09 FAM122A Protein FAM122A 1 RIDFIPVS(0.974)PAPS(0.013)PT(0.013)R 67.214 0.031291 12040000.0 1452.2 1465.1 1759.0 2345.9 1799.5 1660.2 1681.6 1442.7 1130.0 1343.0 True False 1486.0334345106933 1293.5654108934882 1520.1374614953777 1936.2326029968658 1636.7355427275288 1643.4998953409931 1554.7555581360728 1404.434909449951 1917.5274680654047 1515.3871319277955 0.9806295719432697 0.8536204271761781 1.003134730041913 1.2777148242863148 1.08007749851047 1.0845412770862184 1.0259791213603582 0.9267829189385441 1.265371354728364 1.0 10.565470686918312 -5.523930465229382 24.999878176729272 1.0915242848155773 0.9199381155642771 0.311907390792725 0.10628432691813818 38.819206908813854 922744.9709395306 0.028577349286478804 0.05002075710958258 2.9927437656356673e-06 5.523930465229382 -0.1715861692513002 RIDFIPVS(ph)PAPSPTR ddPTM_A459_Selumetinib_30min_R2 3 RIDFIPVSPAPSPTR 15 1 Q96E09 Q96E09 FAM122A Protein FAM122A 1 RIDFIPVS(0.955)PAPS(0.017)PT(0.028)R;RIDFIPVS(0.997)PAPS(0.003)PTR;RIDFIPVS(0.953)PAPS(0.034)PT(0.014)R 111.93 0.0016089 7728000.0 26445.6 24972.3 25225.5 29601.0 29152.6 20369.3 21275.800000000003 19566.2 19036.5 27024.5 True False 24975.859422124657 26887.59511139967 23602.518793447747 25569.292735426825 25490.18976044929 23174.98618090474 22265.166857197906 19623.134402641208 22844.33192425129 26244.232466916554 0.9516704081023971 1.0245144393265888 0.8993411723204728 0.9742823596635735 0.9712682507511772 0.8830506363681657 0.848383235641025 0.7477122612512332 0.87045151551103 1.0 14.679712784971441 -6.894423342952906 3.2978378529866417 0.8470838268888022 0.9648308753685196 0.33047953482074055 0.06488120334163967 0.2401299410932398 5.167751206437331 0.023652854358977796 0.020527544553264433 1.2751951639801833e-07 6.894423342952906 0.1177470484797174 RIDFIPVSPAPS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 RIDFIPVSPAPSPTR 15 1 Q96E09 Q96E09 FAM122A Protein FAM122A 1 RIDFIPVS(0.001)PAPS(0.751)PT(0.248)R 104.81 0.0025079 13734000.0 1774.3 1859.4 2374.0 2226.7 1852.3 1668.8 1720.1 1938.4 1008.5 1643.1 True False 1815.6377378131947 1641.7005835883926 2051.623839448565 1837.8486453357443 1684.7597920501264 1652.013387149168 1590.3514721395456 1886.9873351894262 1711.350842074303 1854.007890149336 0.9793042130295084 0.8854873770014849 1.1065885158036255 0.9912841553159247 0.9087123096948757 0.8910498147966901 0.8577911025025069 1.0177881902311827 0.9230547783356293 1.0 10.8564316683532 -6.249437410019479 23.05969569403528 0.9280908859129542 0.9914334937120322 0.1491486676253213 0.06675621384995767 511.3938304246639 982550.1279307189 0.02025186253805839 0.025894111954645707 5.630702605325338e-07 6.249437410019479 0.06334260779907797 RIDFTPVS(ph)PAPS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 RIDFTPVSPAPSPTR 15 1 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309;Q7Z309-5 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 2 RIDFTPVS(0.999)PAPS(0.933)PT(0.067)R 90.758 0.037313 5507300.0 29394.0 28791.0 31868.0 29975.0 38472.0 23574.0 23410.0 24125.0 23274.0 30095.0 True False 27760.399153505005 30999.177122343885 29817.64757525493 25892.353290240837 33638.80341595619 26821.104516534608 24498.611386034987 24195.199755891237 27929.450329893873 29226.07915379944 0.9498502692550227 1.0606683489500486 1.020241114736685 0.8859331815939049 1.1509858451739354 0.9177113486688075 0.8382448859155343 0.8278633486403125 0.9556345270577629 1.0 14.834968675857823 -6.979205756997948 24.976781066296798 0.889217664971835 1.0119288315145285 0.29457329519224695 0.08034714743688821 257.9408260760214 309821.81732484204 0.027240062174302696 0.024021240336389554 1.0490453015631972e-07 6.979205756997948 0.12271116654269354 RIDFTPVS(ph)PAPSPTR ddPTM_A459_Selumetinib_30min_R2 2 RIDFTPVSPAPSPTR 15 1 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309;Q7Z309-5 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 RIDFT(0.007)PVS(0.827)PAPS(0.103)PT(0.063)R;RIDFT(0.001)PVS(0.623)PAPS(0.306)PT(0.07)R 111.63 0.0016467 13760900.0 26086.0 30930.0 35236.0 34911.0 36761.0 26994.0 23494.0 24700.0 23091.0 30179.0 True False 24636.244550531792 33302.23154437485 32968.95412205604 30156.061575165902 32142.754532490264 30712.178472865664 24586.517552477817 24771.87291069489 27709.845216446643 29307.653855541263 0.8406078723314034 1.136298105215895 1.1249264197182582 1.0289483328759947 1.0967358455549987 1.0479234750160271 0.838911148386898 0.845235617726228 0.9454815234624276 1.0 14.8389898611746 -7.2451444978371216 22.016946375327706 0.8945100675628412 1.0551468333601328 0.36161044072072324 0.08899174144978546 160.48306009657105 216837.80982308838 0.03336710291564213 0.02572426783898451 5.6866369439556766e-08 7.2451444978371216 0.16063676579729158 RIDFTPVSPAPS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 3 RIDFTPVSPAPSPTR 15 1 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309;Q7Z309-5 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 RIDFT(0.005)PVS(0.053)PAPS(0.471)PT(0.471)R;RIDFTPVSPAPS(0.789)PT(0.211)R;RIDFTPVSPAPS(0.867)PT(0.132)R 119.76 0.00096056 12669700.0 37398.6 39542.6 39861.0 49462.0 42983.0 28174.1 36273.0 37519.0 30269.0 40979.2 True False 35320.135530457635 42575.390270501026 37296.38665737531 42725.19027329079 37583.09126710453 32054.82653598448 37959.766373585924 37628.174078395175 36323.6457865239 39796.02401925168 0.8875292545147527 1.0698402998727914 0.9371887663785924 1.0736044950777521 0.9443931194966456 0.8054781181275213 0.9538582637105293 0.9455259666189821 0.9127455991320141 1.0 15.280336679307215 -6.5121161118333335 24.919673507085147 0.9167821884650506 0.995594700368619 0.17514010508914024 0.06943937301786055 754.68407328481 1747390.6823267732 0.021174812998673874 0.022569385673561645 3.0752745074961454e-07 6.5121161118333335 0.07881251190356842 RIDIS(ph)PSTFR ddPTM_A459_Selumetinib_30min_R1 1 RIDISPSTFR 10 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 RIDIS(0.973)PS(0.004)T(0.023)FR 75.483 0.030723 230330000.0 837.26 869.67 980.29 962.67 1121.0 1088.6 852.49 850.19 465.17 625.96 True False 856.7665289756383 767.8486321013859 847.1720023475298 794.557756053963 1019.605747928624 1077.6496723697173 788.1859929563633 827.6401993936742 789.3595153274202 706.308063366733 1.2130210221467959 1.0871299252075783 1.1994369684940955 1.124945044895245 1.4435708734068622 1.525750204851016 1.1159238211147495 1.1717835917780575 1.117585309113999 1.0 9.464153756491516 -8.27411385327096 1.3683520606105923 1.0135822404275876 1.2496300093002632 0.2610896731474478 0.13279059410676672 0.6398341734546636 2.3509748520929947 0.13875045547648968 0.04327343563650159 5.3196878172790705e-09 8.27411385327096 0.23604776887267565 RIDIS(ph)PSTFR ddPTM_A459_Selumetinib_30min_R2 3 RIDISPSTFR 10 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 RIDIS(0.942)PS(0.029)T(0.029)FR;RIDIS(0.958)PS(0.037)T(0.005)FR;RIDIS(0.945)PS(0.043)T(0.012)FR 69.314 0.039697 865862000.0 35588.1 31389.4 39908.7 33708.6 38649.0 25107.5 23005.9 29165.9 21015.300000000003 34215.4 True False 33610.25587245189 33796.866047171025 37341.017691307134 29117.43052942159 33793.56709355613 28565.830221807624 24075.71993532603 29250.76794032534 25218.94721654285 33227.51249971456 1.011518869272583 1.0171350036347546 1.123798168509542 0.8763048551910625 1.017035719837482 0.8597041449326974 0.7245718419497352 0.8803177168491507 0.7589778866762744 1.0 15.02009067261994 -6.816693606977164 4.539280566021094 0.826282085912373 1.009235847922055 0.45722714727771707 0.08899493962331315 0.1749075155647659 7.393445184625066 0.030678726005924768 0.02754858150831794 1.5251283462980147e-07 6.816693606977164 0.18295376200968194 RIDIS(ph)PSTLR ddPTM_A459_Selumetinib_30min_R1 1 RIDISPSTLR 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 RIDIS(0.997)PS(0.002)T(0.001)LR 104.59 0.023393 406400000.0 3132.7 3273.4 3559.7 4186.1 3740.1 3613.9 3298.0 3134.9 2073.7 2587.2 True False 3205.6858148269152 2890.1488062376243 3076.31229203246 3455.076217829057 3401.808615368285 3577.547447158662 3049.2292047649685 3051.752268409686 3518.91744294445 2919.292321462094 1.0981037394779924 0.9900169246463562 1.0537869981077208 1.1835321157898369 1.1652853639763379 1.2254844850093287 1.0445097198206574 1.0453739921739837 1.2054008490598984 1.0 11.511402966077169 -5.620786881383922 7.524751584524228 1.1285383275686725 1.0386977501719716 0.17967557407212909 0.07489631089372276 0.3476697190859792 23.173175356893015 0.020476833970799836 0.035606619156770346 2.394490501498608e-06 5.620786881383922 -0.08984057739670082 RIDIS(ph)PSTLR ddPTM_A459_Selumetinib_30min_R2 1 RIDISPSTLR 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 RIDIS(0.993)PS(0.007)TLR 80.37100000000002 0.02451 153610000.0 19309.0 23301.0 22807.0 24015.0 26807.0 20743.0 15691.0 18900.0 15891.0 22718.0 True False 18235.88308005131 25088.111775476187 21339.62245038406 20744.11557181431 23439.26500237934 23600.159963793907 16420.662591126642 18954.995870936564 19069.64403163803 22062.07231154731 0.8265716303770173 1.137160254993138 0.9672537624316861 0.9402614259838511 1.062423541695637 1.069716372538656 0.7442937526105402 0.8591666097030922 0.8643632276400871 1.0 14.429280690568262 -7.25028265574464 24.958384094143913 0.8552197774928325 1.0053299974562457 0.30560156429801677 0.09787127236324966 777.0030966531159 1738214.0594170277 0.036063838560064926 0.027664794316829753 5.61975450654162e-08 7.25028265574464 0.15011021996341323 RIDISPSTLR ddPTM_A459_Selumetinib_30min_R1 2 RIDISPSTLR 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 0 ; 97.734 0.02717 2609700.0 1658.53 1600.3 2163.4 2225.76 1898.56 2197.0299999999997 1775.4 1834.3799999999999 1054.85 1497.68 False True 1697.1705220624015 1412.9361320407133 1869.6221627055725 1837.0727986897589 1726.8355832179923 2174.9298729436323 1641.4801486172603 1785.7262834940054 1790.0034068042419 1689.9218166385847 1.0042893732434528 0.8360955626048889 1.1063364850951678 1.0870756153346026 1.0218434759620019 1.2870002928714033 0.9713349649999314 1.0566916563311697 1.0592226156146851 1.0 10.722740787171352 -5.274541240809423 24.573512917513455 1.078302195422904 0.9201924637045219 0.3188877027909782 0.08952889805610927 591.1463897940849 1108739.9263992414 0.022696289818512006 0.04772299025508882 5.314455307914411e-06 5.274541240809423 -0.15810973171838205 RIDISPSTLR ddPTM_A459_Selumetinib_30min_R2 1 RIDISPSTLR 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 0 108.31 0.011329 0.0 4568.6 5465.7 6118.8 6421.5 5892.9 3958.9 3755.1 2050.4 3908.6 6274.5 False True 4314.695501554843 5884.901615004511 5725.1230696457205 5546.880622294626 5152.5812188055825 4504.202539683925 3929.7195905894905 2056.366324538006 4690.429215408748 6093.338881891164 0.7081003674976483 0.9657926022289505 0.939570764176641 0.9103187480314674 0.8456088392061327 0.7392010565947671 0.644920570931686 0.3374777547083973 0.7697633934899414 1.0 12.573017262934323 -6.888947036562117 2.3478178990293115 0.6357843314405991 0.8892189721799341 0.19482984913849466 0.16794650383945314 0.3588790685355091 4.028736268963759 0.06579344831268671 0.05605624099717158 1.2913767510506876e-07 6.888947036562117 0.25343464073933497 RIDT(ph)PSLEEPSDLEELEQFAK ddPTM_A459_Selumetinib_30min_R1 2 RIDTPSLEEPSDLEELEQFAK 21 1 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 RIDT(0.804)PS(0.196)LEEPSDLEELEQFAK;RIDT(0.828)PS(0.172)LEEPSDLEELEQFAK 157.55 1.9932e-07 15760700.0 3476.7 3807.5 5325.5 5488.9 4509.3 3774.2 4107.3 4417.200000000001 2181.6 3391.0 True False 3557.7003455194367 3361.716129941271 4602.326350877562 4530.366654413871 4101.434611181575 3736.234974699418 3797.483054193801 4300.041506912266 3702.015862240253 3826.267881137118 0.9298095313865306 0.8785888062134876 1.2028238727262894 1.1840171141042808 1.071915176509461 0.9764697848570543 0.992477048696663 1.123821342491668 0.9675265760901355 1.0 11.901722166516299 -5.233435138551317 24.926133900970306 1.0680661966669684 0.9041991140505246 0.38853663311028663 0.080550815393965 751.3731971701811 668782.8802243212 0.021866269187263206 0.05782678370313703 5.842044509311519e-06 5.233435138551317 -0.1638670826164439 RIDT(ph)PSLEEPSDLEELEQFAK ddPTM_A459_Selumetinib_30min_R2 2 RIDTPSLEEPSDLEELEQFAK 21 1 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 RIDT(0.497)PS(0.497)LEEPS(0.005)DLEELEQFAK;RIDT(0.498)PS(0.498)LEEPS(0.003)DLEELEQFAK 107.91 0.00016002 4102100.0 32196.0 34183.8 33851.4 35765.3 38301.0 24229.3 27784.7 24837.1 20714.6 29046.6 True False 30406.67521079973 36805.58754175885 31673.43777861758 30894.0044414162 33489.2859647156 27566.666143313483 29076.74360433858 24909.371848996747 24858.098814282857 28207.949185869806 1.0779470357962546 1.3047948753465513 1.1228550352920992 1.095223344237018 1.187228668913349 0.9772658750081143 1.0307996307262202 0.8830621356009315 0.8812444552592648 1.0 14.78381416043477 -6.979198007728462 1.1795377982025854 0.918086993593436 1.1706463209334854 0.6363167319824121 0.07532881286995195 0.2825278244508695 0.8090384452545413 0.042060542020199466 0.03087023576824369 1.0490640202151992e-07 6.979198007728462 0.2525593273400494 RIEQHYFEDR ddPTM_A459_Selumetinib_30min_R1 2 RIEQHYFEDR 10 1 C9JNK6;O75431-2;O75431 C9JNK6 MTX2 Metaxin-2 0 ; 132.25 0.0016682 27990000.0 8466.8 9750.6 10339.3 10398.1 9819.599999999999 8207.7 8086.700000000001 7834.5 4711.1 6421.8 False True 8664.059966475099 8608.995219069036 8935.279849709581 8582.267031511028 8931.418913791185 8125.137989995344 7476.713708360479 7626.703609957467 7994.392614869848 7246.100583629125 1.1956858542716786 1.1880866294513015 1.233115624960653 1.1843979989596969 1.2325827954927433 1.1213117864182287 1.031825824396141 1.0525252198662858 1.1032682368405586 1.0 12.822989116743072 -6.9803430291403785 3.62975145990422 1.0524559864329415 1.2055837785886736 0.8713407221153945 0.02890776041415078 0.0773466472547516 2.1965474759115597 0.010748152450043146 0.008929966823799033 1.0463017961532771e-07 6.9803430291403785 0.15312779215573213 RIEQHYFEDR ddPTM_A459_Selumetinib_30min_R2 2 RIEQHYFEDR 10 1 C9JNK6;O75431-2;O75431 C9JNK6 MTX2 Metaxin-2 0 ; 114.89 0.0045999 12617500.0 35138.0 23131.2 31131.0 39757.0 36361.0 29517.0 29832.0 33992.0 27984.0 28189.0 False True 33185.17062855886 24905.288661469243 29128.065352869977 34342.02801534962 31793.00610853567 33582.698821351994 31219.247110986544 34090.91109232148 33581.58193828951 27375.110326182174 1.2122387903883556 0.9097785676373791 1.0640346287485547 1.254498250642816 1.1613836704112976 1.2267603096829438 1.140424522093259 1.2453250666798652 1.2267195104660942 1.0 14.74057715857249 -5.660706114291836 6.897151731640222 1.1888462116810496 1.0436054124362801 0.22356543139370022 0.09777644686475408 0.2520274547247539 14.977549513147778 0.024737676109517572 0.04303702343583797 2.1842074581692833e-06 5.660706114291836 -0.14524079924476951 RIEYIEAR ddPTM_A459_Selumetinib_30min_R1 1 RIEYIEAR 8 1 Q8WUW1;Q8WUW1-2 Q8WUW1 BRK1 Protein BRICK1 0 137.05 0.0034584000000000004 3077700.0 1722.2 2048.1 2203.9 2163.4 2333.9 1850.7 1961.2 1934.1 1188.1 1499.3 False True 1762.323909182148 1808.3074998641416 1904.6224851561487 1785.6028020475815 2122.7991570835115 1832.083638301152 1813.2651050288214 1882.8013851577937 2016.118924609299 1691.749759418722 1.0417166601446275 1.0688977431777311 1.1258299134090428 1.055476906147814 1.2547950104706362 1.0829519130126242 1.071828203275082 1.112931374557852 1.1917359014740034 1.0 10.724300468046014 -5.00693233517766 1.7143549042007094 1.1178046565673783 1.030140967511126 0.10059684463355423 0.06748658976789426 1.3186358364531112 5.378132251324709 0.01854610828233763 0.16561199217499298 9.841644305825177e-06 5.00693233517766 -0.08766368905625233 RILS(ph)DVTHSAVFGVPASK ddPTM_A459_Selumetinib_30min_R1 2 RILSDVTHSAVFGVPASK 18 1 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 RILS(0.739)DVT(0.252)HS(0.009)AVFGVPASK;RILS(0.971)DVT(0.027)HS(0.002)AVFGVPASK 72.227 0.010375 40821500.0 8384.0 8079.5 17263.9 18412.6 13996.9 11353.7 9617.0 8715.0 6122.299999999999 7108.6 True False 8579.330887575847 7133.548383942351 14919.557203814698 15197.185057308525 12730.8828663534 11239.492086334794 8891.581947308885 8483.849889690386 10389.095944899853 8021.05805362764 1.0696008968163147 0.8893525437976478 1.8600485252774241 1.8946608983132065 1.587182486554336 1.401248066176453 1.1085298083944846 1.057697105914031 1.295227621523227 1.0 12.969576839053085 -7.190491423340172 4.110517554120666 1.1188656460326907 1.475699092695762 0.23160730602171764 0.2991226691104255 0.39439332229200114 12.961529278389913 0.13622411113220892 0.101972962800013 6.449240560180144e-08 7.190491423340172 0.3568334466630714 RINPPSSGGTSS(ph)SPIK ddPTM_A459_Selumetinib_30min_R1 1 RINPPSSGGTSSSPIK 16 1 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6;A0A0A0MT46 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 RINPPSSGGTSS(0.971)S(0.029)PIK 214.58 2.0299e-08 7002200.0 2739.1 2888.8 3256.1 3570.1 2979.2 2705.0 2385.4 2607.6 1951.7 2577.2 True False 2802.915700639195 2550.5779530333166 2813.9395044770317 2946.6490540769464 2709.7318860204796 2677.7901559434904 2205.467357503441 2538.437977321476 3311.892353471906 2908.0087240538423 0.9638608293897604 0.8770874488566672 0.9676516721567205 1.013287556431137 0.931816972764456 0.9208329169695815 0.7584115340716585 0.8729127792239995 1.1388866636049975 1.0 11.505815882024937 -8.254809774595454 24.95773800954758 1.0694433357938453 0.9128891056959795 0.4265560695901627 0.0724473743596506 467.55952512578625 1760186.9385736147 0.05516915930914871 0.019779373549248483 5.561478023283605e-09 8.254809774595454 -0.15655423009786584 RINPPSSGGTSS(ph)SPIK ddPTM_A459_Selumetinib_30min_R2 1 RINPPSSGGTSSSPIK 16 1 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6;A0A0A0MT46 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 RINPPSSGGT(0.001)S(0.046)S(0.476)S(0.476)PIK 75.215 0.01602 6857300.0 27473.0 32005.0 32172.0 34088.0 32850.0 23333.0 22354.0 24954.0 17737.0 32863.0 True False 25946.16064313272 34459.68058770504 30102.088546225084 29445.1555949201 28723.089317273912 26546.90895411481 23393.505293610677 25026.6120086429 21284.89561318757 31914.159801671743 0.8129983933267638 1.0797614852420447 0.9432204618041757 0.9226360893692613 0.900010825783022 0.8318222732194321 0.7330133532885696 0.7841852069479186 0.6669420641326931 1.0 14.961909046271005 -6.712967161902088 1.8247746968836698 0.7776552813115729 0.9508381505972777 0.291441995580236 0.10028472532450437 0.36319441354742427 2.4957869044477827 0.038680301249874 0.03665829831149269 1.9365683872165338e-07 6.712967161902088 0.1731828692857048 RINPPSSGGTSSS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 1 RINPPSSGGTSSSPIK 16 1 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6;A0A0A0MT46 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 RINPPS(0.062)S(0.004)GGT(0.001)S(0.007)S(0.224)S(0.703)PIK 95.195 0.015849000000000002 6219500.0 3497.4 3317.9 4009.1 3923.3 3281.5 3308.2 3133.4 2780.0 2206.3 2554.8 True False 3578.8826152442493 2929.4387255501388 3464.6862404099593 3238.169304462083 2984.6889043958786 3274.9225116052685 2897.0451152851874 2706.265369287354 3743.929958223634 2882.7334658593663 1.2414892523465937 1.0162017266750152 1.2018753316748652 1.1232981969412694 1.035367625812093 1.1360476264596273 1.004964610705539 0.9387844562593283 1.2987430168496477 1.0 11.493221737776956 -6.099166408519347 5.790066922278291 1.0664544596151133 1.1430353619225904 0.11268421165262876 0.10655535449640577 0.5519936593318736 26.392175584485265 0.03037624010180182 0.03969537804111486 7.958543446555896e-07 6.099166408519347 0.07658090230747705 RINPPSSGGTSSS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 1 RINPPSSGGTSSSPIK 16 1 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6;A0A0A0MT46 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 RINPPSSGGTS(0.048)S(0.14)S(0.812)PIK 97.32 0.0039457 6639500.0 37250.0 34075.0 36550.0 44073.0 35701.0 24591.0 26271.0 29426.0 21725.0 39372.0 True False 35179.79412356473 36688.442931605976 34198.41279263109 38070.18136983433 31215.921209010532 27978.1870351278 27492.653554998935 29511.62478826345 26070.60704721769 38235.22805925878 0.9200885128510653 0.9595455498459295 0.8944215721592862 0.9956833868188611 0.8164178113605236 0.7317384635908507 0.7190398737099073 0.7718438279621329 0.6818478238657874 1.0 15.22261485880871 -6.43715807814738 4.611519823393629 0.7634732922165968 0.9393205048079261 0.44404280453999245 0.08476826505181921 0.18256830470826035 6.796178227564165 0.0251756056666932 0.02829613577791903 3.654617435705505e-07 6.43715807814738 0.1758472125913293 RIPHS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 RIPHSPAR 8 1 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 RIPHS(1)PAR 65.695 0.043209 24742000.0 13274.0 15542.0 17545.0 19427.0 24783.0 13512.0 14303.0 16119.0 17466.0 23419.0 True False 12536.28422003216 16734.021424593404 16416.17380155164 16781.009086555743 21669.53797716891 15373.155350276395 14968.117840856825 16165.903621355903 20959.6880408149 22742.832620130568 0.5512191216205762 0.7357931926993768 0.7218174655614816 0.7378592353400261 0.9528073454662089 0.6759560520473169 0.6581465946158334 0.7108131116018869 0.9215953171225761 1.0 14.473124332658724 -14.52287874525485 0.1130154367340472 1.8479002490059104 0.5984063788032363 0.4449278500619468 0.10172681164637329 176.28487120386353 1.3099084592058228 34.30297145482821 1.246555341981487 3.00000000017606e-15 14.52287874525485 -1.249493870202674 RIPLAEWESR ddPTM_A459_Selumetinib_30min_R1 1 RIPLAEWESR 10 1 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 111.5 0.011924 8323700.0 1383.5 2246.9 1966.3 2407.0 1387.0 1774.2 1534.1 1772.2 787.28 895.67 False True 1415.7328581776228 1983.8319034445285 1699.2872601127688 1986.6626349859134 1261.546094894739 1756.3531588447092 1418.381601889004 1725.1954990831105 1335.9566593438346 1010.6379690646079 1.4008308627944672 1.9629501009947772 1.6814005728337493 1.965751036273317 1.2482670684363444 1.7378657962655957 1.4034517258457861 1.7070361018395723 1.3218943877403737 1.0 9.981050571939397 -9.376491781194757 0.2990016779140156 0.828290692773411 1.7566575081537883 0.4467920110804181 0.2242962978750794 4.352632878997348 0.6421224653490673 1.168755542239258 0.2757817360891833 4.202504806316224e-10 9.376491781194757 0.9283668153803772 RIPSIVS(ph)SPLNSPLDR ddPTM_A459_Selumetinib_30min_R1 1 RIPSIVSSPLNSPLDR 16 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 RIPS(0.002)IVS(0.612)S(0.386)PLNSPLDR 78.67399999999998 0.013275 57066000.0 1241.4 1473.9 2179.0 2265.4 2329.7 1317.5 2146.8 1799.5 1094.2 1757.8 True False 1270.3222046560895 1301.3351028024792 1883.1037683902387 1869.7904168247157 2118.979046341941 1304.2471461942885 1984.8651476014047 1751.7714144002127 1856.7774827939536 1983.4307524219487 0.6404671315622746 0.6561031189082004 0.94941745059201 0.942705166057112 1.0683403208075075 0.6575713039649529 1.0007231889380077 0.8832027093767408 0.9361443451084239 1.0 10.95378231416878 -5.256972378286389 23.69942813228863 0.9238162965256943 0.6482850407463446 0.5430562078356804 0.10316400280554293 132.0243133889879 700432.1784505756 0.025769896268723825 0.06330355386730745 5.533853041467046e-06 5.256972378286389 -0.27553125577934967 RIPSIVS(ph)SPLNSPLDR ddPTM_A459_Selumetinib_30min_R2 1 RIPSIVSSPLNSPLDR 16 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 RIPSIVS(0.732)S(0.268)PLNSPLDR 114.75 0.0010548 11070000.0 21043.0 25068.0 25473.0 25745.0 26037.0 20865.0 14270.0 16037.0 12158.0 26703.0 True False 19873.51430180329 26990.63499367567 23834.094912905388 22238.48658739784 22765.999286266688 23738.96435638816 14933.58327546857 16083.665014931725 14589.939722903215 25932.015007273876 0.7663698442341951 1.040822897337706 0.9190992256567788 0.8575687844218813 0.8779109251587612 0.9154307657823516 0.5758743881368159 0.6202242675866217 0.5626226777522212 1.0 14.662446692491713 -7.251245252832954 24.457730894469808 0.6580323562094355 0.9012277032878537 0.3596242151824214 0.13223790131431082 465.1181192402772 1115912.1448255999 0.04800853567055022 0.03673914341103311 5.607312329778026e-08 7.251245252832954 0.24319534707841828 RIPSIVSS(ph)PLNSPLDR ddPTM_A459_Selumetinib_30min_R1 1 RIPSIVSSPLNSPLDR 16 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 RIPSIVS(0.099)S(0.901)PLNSPLDR 129.75 0.00043318 50678000.0 1592.5 1773.9 2304.7 2756.6 2150.4 1850.9 1847.6 1582.1 931.55 1663.8 True False 1629.6021515344164 1566.2109633362638 1991.7343988109133 2275.2115577906807 1955.896699683956 1832.2816264827377 1708.234044488705 1540.1375686149356 1580.7723122799357 1877.364936784412 0.8680263062362459 0.83426026162974 1.0609202077793118 1.2119175729827512 1.0418308456501029 0.9759858568686737 0.9099104873102627 0.8203719684106351 0.8420165314195726 1.0 10.874493404364141 -7.2731368163970025 2.9409982011327815 0.873095521241309 1.0081877582059298 0.18622398346524427 0.10760036938786353 0.44983787447097145 7.866645288726113 0.05452243538279021 0.03677568691608076 5.331669047134187e-08 7.2731368163970025 0.1350922369646208 RIQDPTEDAEAEDT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 RIQDPTEDAEAEDTPR 16 1 O96028-3;O96028;H0Y9L4;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 RIQDPTEDAEAEDT(1)PR 113.63 0.0027933000000000003 6304700.0 18659.0 18082.0 16604.0 18448.0 17920.0 12314.0 19533.0 22362.0 14881.0 23008.0 True False 17622.007477895142 19468.831257206144 15535.7167170683 15935.350575424944 15668.729393167383 14010.14172463762 20441.323203905213 22427.069717771607 17857.615809880142 22343.699258036806 0.7886790488176071 0.8713342867879588 0.6953063831397684 0.7131921349009903 0.7012594115332759 0.6270287459046564 0.9148585007271198 1.0037312738043953 0.7992237813287313 1.0 14.44758044000843 -7.3580879867558835 7.3973475703336335 0.9317763837839201 0.7353178517257418 0.5926723903228313 0.0799098433058214 0.20886562850766877 14.051226913479775 0.03481331107243608 0.02336861239419078 4.384418617737643e-08 7.3580879867558835 -0.19645853205817831 RIQQHVGEEAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 RIQQHVGEEASPR 13 1 Q8TER5;Q8TER5-2;Q8TER5-4;Q8TER5-3 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 RIQQHVGEEAS(1)PR 81.346 0.018092 1829600.0 6617.9 5771.0 8395.8 5871.1 9700.0 6120.6 6220.1 6548.4 5328.5 5879.6 True False 6250.103611552727 6213.617143310288 7855.62336865587 5071.446051787588 8481.39928089975 6963.657092725112 6509.346974894329 6567.454759854019 6394.348890729548 5709.840670964587 1.0946196175552603 1.0882295148632573 1.3758043037177756 0.8881939696805669 1.4854003412089871 1.2195886880235334 1.14002252427031 1.1501993029771447 1.1198821927283873 1.0 12.479234773434738 -8.615502155296367 1.1415264830193932 1.0017381580631963 1.1894279544058342 0.11746763270900906 0.15346751332871816 1.3314813292805783 3.6995357398889417 0.14124918856665994 0.04450437110899133 2.423805935773914e-09 8.615502155296367 0.18768979634263783 RIS(ph)ACLSDYSLASDSGVFEPLTK ddPTM_A459_Selumetinib_30min_R2 3 RISACLSDYSLASDSGVFEPLTK 23 1 Q9ULE0 Q9ULE0 WWC3 Protein WWC3 1 RIS(0.756)ACLS(0.207)DY(0.023)S(0.013)LASDSGVFEPLTK;RIS(0.463)ACLS(0.234)DY(0.276)S(0.026)LASDSGVFEPLTK;RIS(0.797)ACLS(0.168)DY(0.015)S(0.019)LAS(0.001)DSGVFEPLTK 76.804 0.00041955 5722400.0 35156.8 33311.0 35600.0 45119.8 39848.6 36797.0 36390.3 34583.1 30197.6 43527.299999999996 True False 33202.92579982123 35865.846588253175 33309.534758349284 38974.405404003606 34842.46261699607 41865.45274009183 38082.52105601148 34683.7310954596 36237.96379144122 42270.55375149278 0.7854859435961061 0.8484830077956236 0.7880080056243163 0.9220225888956383 0.8242726797910853 0.990416472569001 0.900923164619451 0.8205175474956903 0.857286232976342 1.0 15.36736539159404 -5.759990282679542 24.99989677756592 0.8951019159826887 0.8114413794633888 0.34290646103065836 0.059541259576423367 49.08741578156717 846823.2642339786 0.016333927616557976 0.02645006397793745 1.7378397124036016e-06 5.759990282679542 -0.08366053651929994 RIS(ph)EMEEELK ddPTM_A459_Selumetinib_30min_R1 2 RISEMEEELK 10 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RIS(1)EMEEELK;RIS(1)EMEEELK 172.33 7.5698e-05 9177600.0 4626.9 5456.4 5408.5 6605.1 5172.7 5318.799999999999 4911.8 4986.799999999999 3275.4 4273.1 True False 4734.697767619832 4817.562151388458 4674.055406763929 5451.643278082869 4704.830198314357 5265.297701084006 4541.2989714871355 4854.533864590708 5558.114574249053 4821.594008518734 0.9819776943588833 0.9991637916582872 0.9694004510761097 1.1306724017930525 0.9757831517962566 1.0920242749143418 0.941866727779988 1.006831735731747 1.1527545795911152 1.0 12.235294461824909 RIS(ph)FSASHR ddPTM_A459_Selumetinib_30min_R1 3 RISFSASHR 9 1 E9PKY8;E9PJM0;Q03393 E9PKY8 PTS 6-pyruvoyl tetrahydrobiopterin synthase 1 RIS(1)FSASHR;RIS(0.956)FS(0.043)AS(0.001)HR;RIS(0.998)FS(0.002)ASHR 107.03 0.0065852 25806700.0 4344.1 5169.5 5014.0 5489.300000000001 6714.700000000001 4592.1 5664.5 5204.700000000001 2540.9300000000003 3715.0200000000004 True False 4445.309077852846 4564.252536764649 4333.126339930543 4530.696801922799 6107.356570576568 4545.9076432932 5237.222204484883 5066.654448751761 4311.772627815426 4191.879004359194 1.0604573923126372 1.0888321280309423 1.0336954705573476 1.0808271892416892 1.4569496314720538 1.0844558343802018 1.2493734191847192 1.2086833717010619 1.0286014036501416 1.0 12.033381359760206 -6.031073302301411 24.997452970956473 1.1892945574367328 1.0626923383064284 0.1430717790526913 0.12239265228621932 1073.9436926983094 863950.733994613 0.03483440398311935 0.045024752470669845 9.309507318859473e-07 6.031073302301411 -0.12660221913030445 RIS(ph)FSASHR ddPTM_A459_Selumetinib_30min_R2 3 RISFSASHR 9 1 E9PKY8;E9PJM0;Q03393 E9PKY8 PTS 6-pyruvoyl tetrahydrobiopterin synthase 1 RIS(0.96)FS(0.04)ASHR;RIS(0.494)FS(0.494)AS(0.011)HR;RIS(0.998)FS(0.002)ASHR 77.67399999999998 0.02742 64084200.0 111084.0 86610.0 114525.0 122745.0 120365.0 82090.8 88599.0 89656.0 85225.0 115208.0 True False 104910.39598448484 93252.70850495675 107156.58618539196 106026.91925306432 105243.6726232472 93398.06255391287 92719.02905558799 89916.88411665027 102272.38138546022 111881.64569366752 0.9376908547781824 0.8334942512401284 0.9577673399512482 0.9476703582227108 0.940669686888633 0.8347934281342018 0.828724215493336 0.8036785976749317 0.9141122366530297 1.0 16.771613854463226 -6.757258021078657 24.999819052687997 0.861020514005417 0.9217116376814006 0.10478352232532628 0.06125680358743603 184.57598106122063 1103556.5378593078 0.020169864784618487 0.019481277577163943 1.748807386366235e-07 6.757258021078657 0.060691123675983616 RIS(ph)GLIYEETR ddPTM_A459_Selumetinib_30min_R1 3 RISGLIYEETR 11 1 P62805 P62805 HIST1H4A Histone H4 1 RIS(1)GLIYEETR;RIS(1)GLIYEETR;RIS(0.998)GLIYEET(0.002)R 98.421 0.0093765 78014500.0 9356.2 9561.599999999999 9442.099999999999 9517.9 8113.3 8356.7 7945.0 7880.3 4263.02 5674.1 True False 9574.181256003954 8442.123426932752 8159.914681742754 7855.777438110688 7379.453447519454 8272.639185276515 7345.702253443803 7671.288845178104 7234.033581338216 6402.426005414369 1.4953989703133332 1.3185819593687556 1.2745035514416132 1.22700011393607 1.15260269174198 1.292110081128709 1.1473310659477718 1.1981846941597905 1.1298894474095567 1.0 12.644402958960642 -1.5228787452803376 0.18996889059764782 1.0457658991929182 2.7904023523113883 0.7951945709650924 0.05732896012838262 26.08124083433398 0.30480387966925315 0.11915084409486215 13.337306382409624 0.029999999999999995 1.5228787452803376 1.7446364531184702 RIS(ph)GLIYEETR ddPTM_A459_Selumetinib_30min_R2 1 RISGLIYEETR 11 1 P62805 P62805 HIST1H4A Histone H4 1 RIS(1)GLIYEETR 109.84 0.0047058 2316200.0 10862.0 8691.4 9298.3 11090.0 11360.0 6920.3 9417.0 9398.0 6987.9 8017.7 True False 10258.333524031144 9358.002432744248 8700.057501223575 9579.522868682934 9932.855240311465 7873.508508771293 9854.9091594315 9425.34662407735 8385.675258239466 7786.208168513636 1.3175005473799746 1.201869026644668 1.1173676984909575 1.2303193879944307 1.2756986488594764 1.01121217650084 1.2656878606564115 1.210518190637667 1.0769908891146776 1.0 12.926705201100122 -14.522878742986265 0.1174591444228775 0.3663486989988077 1.2873696030985182 0.38286181062068025 0.08384397827370606 180.68740113742822 1.3798530409591938 27.061156006310263 0.8683777119906488 3.0000000158468925e-15 14.522878742986265 0.9210209040997106 RIS(ph)HSLYSGIEGLDESPSR ddPTM_A459_Selumetinib_30min_R2 1 RISHSLYSGIEGLDESPSR 19 1 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 RIS(0.755)HS(0.226)LY(0.006)S(0.012)GIEGLDESPSR 65.023 0.012657 8115400.0 9483.6 8996.7 6297.1 6894.5 10578.0 8337.7 2140.7 7679.7 7581.5 8994.4 True False 8956.53947785875 9686.717961050022 5891.951441764083 5955.45720632412 9249.09707148016 9486.142492895171 2240.2467917165773 7702.0466555572275 9098.011844809245 8734.708301742276 1.0253965179435045 1.1089915800757597 0.6745447287104985 0.6818152364786138 1.058890205828085 1.0860285386980821 0.2564764287858044 0.8817749133100338 1.0415930939553533 1.0 13.092543809366036 RIS(ph)LSDMPR ddPTM_A459_Selumetinib_30min_R1 2 RISLSDMPR 9 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 RIS(0.784)LS(0.216)DMPR;RIS(0.892)LS(0.108)DMPR 94.402 0.011961 7987900.0 1204.97 893.29 885.4 955.46 1394.67 932.45 1784.3000000000002 2004.49 1174.77 955.06 True False 1233.0434565365297 788.7031915207457 765.1675431540691 788.6068472055009 1268.5223447489868 923.0703995968611 1649.7088144518282 1951.324413698852 1993.4988881939794 1077.6512540721965 1.1441952597161111 0.7318723831484606 0.7100326197948332 0.7317829810205638 1.1771176806555297 0.8565576257706657 1.5308373726824496 1.8107197540254747 1.849855303987264 1.0 10.073674658092882 -7.301530153792071 4.41542978107967 1.6295852640359538 0.8795040387359744 0.5865959226289656 0.2669571646546916 0.13696139862103407 6.172116150104737 0.11212915077620043 0.07601798986512348 4.994245031260685e-08 7.301530153792071 -0.7500812252999794 RIS(ph)LSDMPR ddPTM_A459_Selumetinib_30min_R2 3 RISLSDMPR 9 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 RIS(0.801)LS(0.199)DMPR;RIS(0.715)LS(0.285)DMPR;RIS(0.889)LS(0.111)DMPR 105.36 0.007080800000000002 24581100.0 27233.4 19011.2 28784.1 32749.800000000003 32925.0 21531.5 25129.3 39020.0 45136.0 56380.0 True False 25719.876651937928 20469.29790935723 26932.16234375847 28289.22074344383 28788.667146765398 24497.26868150358 26297.86224276328 39133.541739891254 54164.461205211366 54752.162907167774 0.4697508789843782 0.37385368581809086 0.4918922087045569 0.5166776843393049 0.525799632711799 0.4474210219427983 0.480307276396574 0.7147396497603598 0.9892661463812332 1.0 15.740628337026918 -8.041713796323723 2.194172927611561 1.0087755510071075 0.4695629028383477 0.9626645728219659 0.04119489060581172 0.0601018399658087 0.5268522087037116 0.03854440773994929 0.012654325684790949 9.084189886322194e-09 8.041713796323723 -0.5392126481687598 down RIS(ph)MEDLNK ddPTM_A459_Selumetinib_30min_R1 1 RISMEDLNK 9 1 Q00537-2;F5H6Z0;Q00537;F8VQZ9;F8VZY6 Q00537-2 CDK17 Cyclin-dependent kinase 17 1 RIS(1)MEDLNK 85.554 0.017977 3186900.0 3828.9 4199.5 4121.8 4597.0 3358.7 4047.3 3456.2 3311.8 2491.7 2712.1 True False 3918.1059202575348 3707.8205877054174 3562.082199426747 3794.220246377337 3054.9061780266484 4006.5878366543775 3195.4960513974142 3223.9603057575027 4228.232913432362 3060.224453091117 1.2803328580359117 1.211617201463823 1.1639937704009606 1.239850313118312 0.9982621290869378 1.309246396161348 1.0442031623430954 1.053504523990388 1.3816741151654564 1.0 11.579421756366267 -14.522878744326288 0.022391092148287675 2.29103971095464e-06 1.9534649082338593 0.14320508943226562 0.12096277752613578 5364.2285860124775 9.049160824614505 551.5945392477039 280.19715170796036 3.0000000065903403e-15 14.522878744326288 1.9534626171941483 RIS(ph)QSQPVR ddPTM_A459_Selumetinib_30min_R1 4 RISQSQPVR 9 1 E7EMW7;O95071-2;O95071 E7EMW7 UBR5 E3 ubiquitin-protein ligase UBR5 1 RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR 122.18 0.010823 188005000.0 12037.61 14401.2 17132.5 16646.7 15364.83 12825.4 14055.800000000001 13728.399999999998 7965.95 10636.380000000001 True False 12318.06289188835 12715.100809063762 14806.000602086171 13739.666342260078 13975.083839381063 12696.388120531474 12995.5596896105 13364.278235872118 13517.635340031515 12001.662980114788 1.0263630058849174 1.0594449144365283 1.233662420501043 1.144813545008299 1.1644289514324788 1.0578857397985393 1.0828132493923943 1.1135355373680305 1.126313525253 1.0 13.550946702628188 -6.768864708480509 24.996997267539967 1.0836245619390465 1.129114411682182 0.13217344176519819 0.061813258021787186 424.3692299153755 1428607.7450049932 0.022789149196116312 0.020497121480077474 1.7026888478166189e-07 6.768864708480509 0.045489849743135524 RIS(ph)QSQPVR ddPTM_A459_Selumetinib_30min_R2 5 RISQSQPVR 9 1 E7EMW7;O95071-2;O95071 E7EMW7 UBR5 E3 ubiquitin-protein ligase UBR5 1 RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR;RIS(0.5)QS(0.5)QPVR 103.43 0.0078272 207009400.0 38686.9 36802.2 49557.0 49419.5 47250.100000000006 39457.1 33786.7 39971.2 38286.899999999994 52405.50000000001 True False 36536.83697393119 39624.810402275834 46368.556573581925 42688.47884660741 41314.120016746536 44891.95736910823 35357.84849707594 40087.509574411626 45945.349825367906 50892.41704915891 0.7179230048877199 0.7785994987033281 0.9111093412755928 0.838798416773426 0.8117932378185078 0.8820952112717577 0.6947567151884819 0.7876912101794966 0.9027936279974197 1.0 15.635163090849385 -8.513263667908241 3.3604213662086155 0.9992150788774721 0.8066733640402239 0.5021886218200113 0.06275859876942969 0.18661875119621443 5.337500756963534 0.06312108117294814 0.016709659169229334 3.0671592960227644e-09 8.513263667908241 -0.19254171483724813 RIS(ph)QVSSGETEYNPTEAR ddPTM_A459_Selumetinib_30min_R1 3 RISQVSSGETEYNPTEAR 18 1 H7C3Y7;H0Y764;A0A494C1V1;Q6ZNJ1-2;Q6ZNJ1-3;Q6ZNJ1 H7C3Y7 NBEAL2 Neurobeachin-like protein 2 1 RIS(0.998)QVS(0.002)SGETEYNPTEAR;RIS(1)QVSSGETEYNPTEAR;RIS(1)QVSSGETEYNPTEAR 276.8 1.5240999999999996e-66 11238900.0 1878.45 2449.31 2788.74 3112.96 2813.3 2399.1 2614.2799999999997 2297.31 855.24 1910.62 True False 1922.214230172573 2162.5436465466723 2410.044425452315 2569.3399734963637 2558.8375117284572 2374.9672322085125 2417.082754831098 2236.377876085442 1451.27981574182 2155.866688014806 0.8916201733895762 1.0030971110454026 1.1179004893255085 1.19178982066943 1.1869182477533988 1.1016299131165024 1.1211652224455624 1.0373451607737272 0.6731769750931151 1.0 11.074052253807096 -8.078844870273116 7.008041034343987 0.8384642608722106 1.0930571394467636 0.4447376730522177 0.11053913547510082 0.23773862702185425 18.002332790786934 0.07675739084157113 0.02876313260102277 8.339790282273518e-09 8.078844870273116 0.25459287857455304 RIS(ph)QVSSGETEYNPTEAR ddPTM_A459_Selumetinib_30min_R2 2 RISQVSSGETEYNPTEAR 18 1 H7C3Y7;H0Y764;A0A494C1V1;Q6ZNJ1-2;Q6ZNJ1-3;Q6ZNJ1 H7C3Y7 NBEAL2 Neurobeachin-like protein 2 1 RIS(0.995)QVS(0.005)SGETEYNPTEAR;RIS(1)QVSSGETEYNPTEAR 187.06 3.4638e-10 19585800.0 43749.0 35726.0 49734.0 54943.0 54431.0 32475.0 40997.0 48562.0 35640.0 46822.0 True False 41317.60572112302 38466.069322804266 46534.16858628495 47459.66861803842 47592.89116068599 36948.13647130151 42903.44173401438 48703.307380128106 42768.995864802666 45470.127201834104 0.9086758332062994 0.8459635301229744 1.0234008886697799 1.0437549120408898 1.0466848036168737 0.8125804510573515 0.943552269901805 1.071105589037446 0.9405954743640461 1.0 15.472631419550058 -5.258937455665679 24.889384871952707 0.9843821859167752 0.877319677203639 0.26454864736898853 0.07194489287161046 290.3694210137539 2888576.1472233534 0.019644466070161997 0.047237513383971065 5.50887025945366e-06 5.258937455665679 -0.10706250871313616 RIS(ph)SSSVQPCSEEVSTPQDSLAQCK ddPTM_A459_Selumetinib_30min_R1 1 RISSSSVQPCSEEVSTPQDSLAQCK 25 1 J3QS41;P42694 J3QS41 HELZ Probable helicase with zinc finger domain 1 RIS(0.457)S(0.154)S(0.154)S(0.154)VQPCS(0.061)EEVS(0.019)T(0.002)PQDSLAQCK 66.47399999999999 0.0010251 9908000.0 1281.8 1346.1 1305.8 1998.8 1749.5 1315.6 1305.5 1278.4 1037.6 1346.1 True False 1311.663446051374 1188.4979862150883 1128.4795322459713 1649.7471021229105 1591.2580338993125 1302.3662584692256 1207.0250839359207 1244.492679171566 1760.7314166943943 1518.8850471243525 0.8635699248831876 0.7824805362757548 0.7429657263283215 1.086156655005798 1.0476487584837189 0.8574488641750383 0.7946783637255075 0.8193461918186085 1.1592262495624144 1.0 10.568796972001008 -1.5228787452803376 0.22401330688703439 0.9805531103725326 0.015921475763089263 0.1462303823261606 0.12753222704710232 119.9585551642392 1.5487328532512832 0.2100826986685091 42.07076016246388 0.029999999999999995 1.5228787452803376 -0.9646316346094433 RIS(ph)SSSVQPCSEEVSTPQDSLAQCK ddPTM_A459_Selumetinib_30min_R2 1 RISSSSVQPCSEEVSTPQDSLAQCK 25 1 J3QS41;P42694 J3QS41 HELZ Probable helicase with zinc finger domain 1 RIS(0.493)S(0.177)S(0.064)S(0.26)VQPCS(0.007)EEVSTPQDSLAQCK 102.06 1.2003e-06 29581000.0 84151.0 71938.0 102460.0 105460.0 111860.0 55861.0 79081.0 91287.0 60375.0 83310.0 True False 79474.22430314348 77455.4132828722 95867.83515001305 91096.16607135291 97807.1467589119 63555.34569433019 82758.42319602863 91552.63005662372 72451.6870184474 80904.62383462496 0.9823199285320784 0.9573669539728261 1.18494877803244 1.125969836502302 1.2089191213451156 0.7855588800986458 1.0229133920107332 1.1316118377086095 0.8955197315612518 1.0 16.3039345369965 -6.7330707560876375 24.999918010355483 0.9788331608481016 1.0914921006094103 0.23621539725981688 0.11119745752573935 379.4272575188801 334370.28927256336 0.038407356196198617 0.038400467273501784 1.8489673571394465e-07 6.7330707560876375 0.1126589397613087 RIS(ph)TSDILSEK ddPTM_A459_Selumetinib_30min_R2 2 RISTSDILSEK 11 1 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 RIS(0.945)T(0.043)S(0.011)DILS(0.001)EK;RIS(0.83)T(0.131)S(0.039)DILSEK 103.77 0.006655299999999999 7037200.0 46660.0 47257.0 55477.0 54430.0 53798.0 37179.0 45598.0 61065.0 55300.0 81055.0 True False 44066.82399477934 50881.45994479544 51907.670218790554 47016.540103012776 47039.41427977779 42300.06977264109 47718.39735072291 61242.68904014503 66361.54521109951 78714.73154381834 0.5598294389182861 0.6464032709870975 0.6594403512625203 0.597302934036432 0.5975935299174873 0.5373844125872905 0.6062194002930618 0.7780333850983522 0.8430638574198509 1.0 16.264346042427256 -8.21041849378723 1.3979036016332451 0.9853679511191727 0.6000122227518253 0.9106155608540425 0.041635725371363064 0.11504012942407747 0.4242696764334754 0.041448360072416264 0.013036315677867002 6.160011262731798e-09 8.21041849378723 -0.38535572836734744 RISACLSDY(ph)SLASDSGVFEPLTK ddPTM_A459_Selumetinib_30min_R1 1 RISACLSDYSLASDSGVFEPLTK 23 1 Q9ULE0 Q9ULE0 WWC3 Protein WWC3 1 RIS(0.181)ACLS(0.054)DY(0.444)S(0.283)LAS(0.036)DS(0.002)GVFEPLTK 60.464 0.018456 14578000.0 3200.9 3502.6 4149.4 4685.1 4038.6 3421.2 3651.7 3488.9 2155.2 3148.1 True False 3275.474742132817 3092.5139636854365 3585.9342710226947 3866.9352352191563 3673.309343072741 3386.785834201061 3376.2493289994636 3396.3630384556277 3657.2169904199654 3552.189300090762 0.9221002782844724 0.8705937951016348 1.0094997670678953 1.088606182987025 1.0340972940205873 0.9534361904965271 0.950469990130649 0.9561323317901012 1.0295670307679041 1.0 11.794492751210774 -5.267439448326824 24.93596284170595 1.001720301040994 0.8963470342468532 0.5041687386889864 0.04218888413786123 377.5455766921154 1569065.510753171 0.012458501152521537 0.027046972083621886 5.402074281401679e-06 5.267439448326824 -0.10537326679414083 RISGLIYEETR ddPTM_A459_Selumetinib_30min_R1 2 RISGLIYEETR 11 1 P62805 P62805 HIST1H4A Histone H4 0 ; 134.99 0.0051317 8911200.0 5825.4 5382.1 7191.799999999999 7353.4 5937.4 5750.0 5517.5 6831.0 2902.2 4174.2 False True 5961.120485744794 4751.96122992959 6215.193061729655 6069.266730413549 5400.363218333111 5692.160220582278 5101.310532835263 6649.819689784858 4924.821431698602 4709.999230151153 1.2656308832461296 1.0089091309208327 1.3195741141406083 1.2885918731283477 1.1465741191129246 1.2085267836444225 1.0830809695634604 1.4118515449463147 1.045609816700661 1.0 12.201511108691822 -8.499942316639762 24.243430059978266 0.9999998809861846 1.2097167859059996 0.3312826232211198 0.11073550279926918 477.5117193154068 504722.24368903163 0.1020549563023165 0.026350476420944735 3.1626977044552845e-09 8.499942316639762 0.20971690491981498 RISLS(ph)DMPR ddPTM_A459_Selumetinib_30min_R2 1 RISLSDMPR 9 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 RIS(0.356)LS(0.644)DMPR 63.602 0.048194 6764000.0 6624.0 3388.6 5736.2 7024.3 5290.1 3278.0 6638.5 7430.4 7218.9 7980.7 True False 6255.8645979729545 3648.494723933675 5367.139137102339 6067.578222406624 4625.510343905956 3729.514745278716 6947.203403938196 7452.021233831062 8662.881712918746 7750.276454651182 0.8071795418624862 0.4707567201353314 0.6925093793114119 0.7828853922707857 0.5968187549142254 0.48121054353364623 0.8963813671148418 0.9615168281331271 1.1177513168217221 1.0 12.9200320573252 -7.477565841470087 3.873339664906261 1.020058372748025 0.6384603847012207 0.7192501726112523 0.11061578644618274 0.12395309183280777 3.873644164486622 0.05213892239829782 0.03200531200213477 3.329922749922727e-08 7.477565841470087 -0.38159798804680434 RISS(ph)SSVQPCSEEVSTPQDSLAQCK ddPTM_A459_Selumetinib_30min_R2 1 RISSSSVQPCSEEVSTPQDSLAQCK 25 1 J3QS41;P42694 J3QS41 HELZ Probable helicase with zinc finger domain 1 RIS(0.266)S(0.4)S(0.098)S(0.14)VQPCS(0.095)EEVSTPQDSLAQCK 101.06 1.6181e-06 28907000.0 27025.0 21632.0 32320.0 35070.0 42520.0 19505.0 26410.0 30484.0 22044.0 28725.0 True False 25523.05868964662 23291.104842157012 30240.566387355317 30293.405500875604 37178.25746637706 22191.636701238982 27638.117330422203 30572.70339310214 26453.4159608224 27895.63461348695 0.9149481287407873 0.8349372640153616 1.0840608864562142 1.0859550578651966 1.3327625623688861 0.795523636895853 0.9907685454504683 1.095967301576315 0.9482994858282497 1.0 14.767751751989971 -5.261927253716406 24.995235548352458 1.0464639134423763 0.8749426900005874 0.20818350493280025 0.12979199058346474 63.8542478359425 3271660.1030356507 0.03434707695361065 0.0793183012069097 5.471075982082494e-06 5.261927253716406 -0.17152122344178888 RIVS(ph)DGEDEDDSFK ddPTM_A459_Selumetinib_30min_R2 2 RIVSDGEDEDDSFK 14 1 Q2NKX8;B5MDQ0 Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like 1 RIVS(1)DGEDEDDSFK;RIVS(1)DGEDEDDSFK 137.85 0.00029962 7385600.0 49953.0 46412.0 49157.0 47514.0 50858.0 41951.0 50021.0 50647.0 41147.0 46971.0 True False 47176.8122377028 49971.65116189866 45994.29213809481 41042.51123377825 44468.763363711296 47729.36945673811 52347.075614731155 50794.374384937815 49377.5497432389 45614.82518468566 1.0342429691814659 1.0955133766176468 1.008318939114044 0.8997625457864852 0.9748752337352127 1.0463565137757531 1.147589087600093 1.113549688709343 1.0824890711148996 1.0 15.477215167631964 -7.0063765591762985 6.8432845947732845 1.095797133869455 1.0029128746541016 0.3113523794253996 0.05776618850410334 0.17090436244110485 43.899871194876084 0.023037723698090817 0.019109132302923715 9.854246932197067e-08 7.0063765591762985 -0.09288425921535337 RKADTTTPTPTAILAPGSPAS(ph)PPGSLEPK ddPTM_A459_Selumetinib_30min_R1 1 RKADTTTPTPTAILAPGSPASPPGSLEPK 29 2 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;H0YDJ7;U3KPW0;E9PIQ3;U3KQA6;A0A0G2JHL0;A0A140T9F7;A0A140T9V2 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 RKADTTTPTPTAILAPGS(0.155)PAS(0.824)PPGS(0.021)LEPK 72.035 8.178e-05 12096000.0 2111.5 2171.5 3135.6 3356.8 2292.3 2279.6 2440.6 1895.2 1569.5 1948.1 True False 2160.6938417362126 1917.2597704970392 2709.802742617913 2770.597894940055 2084.961869738436 2256.6692937111948 2256.503577061666 1844.9331395228028 2663.3268682554462 2198.1576111009203 0.9829567410564594 0.872212147488734 1.232760894365869 1.2604182161225623 0.9485042652124513 1.0266185110270458 1.0265431221428767 0.8393088512878704 1.2116177906467551 1.0 11.102079117992718 RKAS(ph)PEPEGEAAGK ddPTM_A459_Selumetinib_30min_R1 1 RKASPEPEGEAAGK 14 2 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 RKAS(1)PEPEGEAAGK 61.167 0.033952 9189100.0 7245.8 8158.7 10201.0 10648.0 8623.3 7941.9 8157.1 7632.2 4718.9 6583.9 True False 7414.613042127516 7203.475611123272 8815.760230082062 8788.526687714999 7843.324037567264 7862.011696668244 7541.8033796811105 7429.769263120484 8007.628645180386 7429.007697616833 0.9980623717089518 0.9696416943320829 1.1866672628310895 1.1830014243401967 1.0557700781604171 1.0582855768463284 1.0151831424404718 1.000102512412781 1.0778867072313265 1.0 12.858953805609987 -6.914925699872973 2.4916099479344336 1.0242488283446955 1.084981277277698 0.12772288442294422 0.06761038738741873 0.6651713091297141 8.383554348033298 0.030167992096358183 0.025402475576751522 1.2163940864229123e-07 6.914925699872973 0.06073244893300256 RKAS(ph)PEPEGEAAGK ddPTM_A459_Selumetinib_30min_R2 1 RKASPEPEGEAAGK 14 2 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 RKAS(1)PEPEGEAAGK 130.27 0.022364 0.0 3426.4 3060.1 2945.5 3133.9 3185.2 2579.0 2793.0 2455.6 2268.6 3129.5 True False 3235.974404965965 3294.79983022766 2755.9897368179177 2707.0574137209583 2785.046699950709 2934.2338401689476 2922.880034224507 2462.7453894535347 2722.3833899801148 3039.1432035825037 1.0647653592471191 1.0841212833747984 0.9068311534544314 0.890730456705664 0.9163920596659384 0.9654806120060778 0.9617447545015493 0.8103420024928346 0.895773317549171 1.0 11.569448940513013 -5.262024916773818 24.959400404825463 0.9138061737769868 1.0744433340532165 0.6157448799339141 0.04919644634580361 30.58272317029616 1303709.9398803795 0.013118925408590854 0.030248502900603137 5.469845798518093e-06 5.262024916773818 0.16063716027622965 RKAS(ph)PEPPDSAEGALK ddPTM_A459_Selumetinib_30min_R1 1 RKASPEPPDSAEGALK 16 2 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RKAS(1)PEPPDSAEGALK 98.804 0.0077878 29821000.0 3989.3 3755.5 5762.1 5780.2 4977.2 4287.9 4193.3 3945.3 2312.4 3766.0 True False 4082.242928173464 3315.8043141154158 4979.638468949695 4770.7965777921 4527.013138796032 4244.767619101696 3876.996004954802 3840.657827859495 3923.973908986235 4249.402783946446 0.9606627415022918 0.7802988990928292 1.1718443089843027 1.1226981343861766 1.0653292636552019 0.9989092196997045 0.9123625605935648 0.9038111996275986 0.9234177385609036 1.0 12.053044382105098 -7.151235925853313 4.557718103510246 0.9271909588608724 1.0217605013904876 0.13490904760822908 0.10141381878427493 0.4875346130755998 16.323303409903538 0.04362177401978511 0.03336938774609251 7.059339589733112e-08 7.151235925853313 0.09456954252961514 RKAS(ph)PEPPDSAEGALK ddPTM_A459_Selumetinib_30min_R2 2 RKASPEPPDSAEGALK 16 2 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RKAS(0.998)PEPPDS(0.002)AEGALK;RKAS(0.971)PEPPDS(0.029)AEGALK 60.062 0.029066 116958000.0 205043.0 194721.0 189786.0 194027.0 180729.0 138731.0 133402.0 137470.0 105441.0 169849.0 True False 193647.53091216309 209655.4745733019 177575.37538337297 167600.18788475552 158024.20728224042 157839.93597536982 139605.45733104832 137870.01494061638 126532.14626769553 164945.01804929983 1.1740126085789657 1.2710627883931525 1.0765731362089281 1.0160973024032898 0.9580417108142613 0.9569245427478967 0.846375713447266 0.8358543748160305 0.7671171143215539 1.0 17.331625678261986 -5.85744564200233 0.768480804918619 0.8534917486462053 1.2633964994726907 0.7898468323220612 0.06757891514958814 0.3669766938960103 0.401189973922417 0.03311955800387496 0.1012978658471103 1.3885270925403157e-06 5.85744564200233 0.4099047508264855 RKDPLTHTS(ph)NSLPR ddPTM_A459_Selumetinib_30min_R2 1 RKDPLTHTSNSLPR 14 2 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0;A0A2R8Y5N9;A0A2R8YFW8;A0A2R8YCL5 A0A2R8Y7K2 SPAST Spastin 1 RKDPLTHT(0.177)S(0.446)NS(0.376)LPR 95.662 0.0048301 11845000.0 49090.0 44198.0 83931.0 96526.0 111920.0 83905.0 45321.0 57442.0 54653.0 89333.0 True False 46361.774322840036 47587.84448103071 78530.9708371632 83378.9922833625 97859.60902250504 95462.15213624485 47428.5163018578 57609.146709964974 65585.12713240909 86753.72417499137 0.5344067331256405 0.5485394999878165 0.9052172870268715 0.9610998614327879 1.1280162316157396 1.1003810273745445 0.5467029427600077 0.6640538750101527 0.7559920655408061 1.0 16.40463807076734 -5.257601849070674 23.10919167657251 0.87802300246488 0.5414729819041418 0.3789463073976188 0.17464437644563194 133.48037559300568 803775.5311914112 0.05109417423383182 0.12447713671801126 5.525838029207464e-06 5.257601849070674 -0.33655002056073813 RKDPLTHTSNS(ph)LPR ddPTM_A459_Selumetinib_30min_R2 1 RKDPLTHTSNSLPR 14 2 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0;A0A2R8Y5N9;A0A2R8YFW8;A0A2R8YCL5 A0A2R8Y7K2 SPAST Spastin 1 RKDPLTHT(0.003)S(0.225)NS(0.771)LPR 107.73 0.002 7843200.0 30135.0 25498.0 52418.0 74686.0 78859.0 56060.0 35172.0 33669.0 34159.0 62392.0 True False 28460.217339963037 27453.614611007746 49045.482948403165 64513.63795946379 68952.0274115952 63781.756137988064 36807.56769199584 33766.971215797 40991.75448220524 60590.5808461158 0.46971355848600516 0.45310037018349 0.8094572170048319 1.064746979787362 1.1379991155178937 1.052667844528129 0.6074800270602689 0.5572973677469153 0.6765367472926782 1.0 15.886805915445946 -5.295096751171108 4.806280511788236 0.8647141155548655 0.4573349742234601 0.4159224435904516 0.19121228689554773 0.20624877372455405 12.254511024078086 0.0589548219341336 0.1361996756957264 5.068777745779308e-06 5.295096751171108 -0.40737914133140546 RKEDEVEEWQHR ddPTM_A459_Selumetinib_30min_R1 3 RKEDEVEEWQHR 12 2 P15311;E7EQR4 P15311 EZR Ezrin 0 ;; 96.067 0.011074 9937800.0 6632.7 7496.199999999999 8212.1 7993.500000000001 6543.5 6854.5 5285.7 5914.2 3706.0299999999997 4806.97 False True 6787.229005012446 6618.541419111162 7096.94192583638 6597.585281578692 5951.641580348759 6785.549953388044 4886.995393458518 5757.336203970958 6288.862232278259 5423.991423352909 1.2513347598209943 1.2202344920043822 1.3084353148643653 1.2163708912172857 1.097280787488723 1.2510251996662396 0.900996150623992 1.061457468236922 1.159452834899713 1.0 12.40513918188708 -6.668081556620734 1.1540808383638803 1.045190043156927 1.2550559933542915 0.5137795525619566 0.08540492508953046 0.3956942602790357 1.1188062604106284 0.04246670846996005 0.04195421042780328 2.1474271686407163e-07 6.668081556620734 0.20986595019736454 RKEDEVEEWQHR ddPTM_A459_Selumetinib_30min_R2 5 RKEDEVEEWQHR 12 2 P15311;E7EQR4 P15311 EZR Ezrin 0 ;;;; 134.75 0.00076397 244835400.0 407414.0 356683.0 356717.0 290872.0 299523.0 344495.0 380162.0 322646.0 255644.0 330205.0 False True 384771.56088746333 384039.4391833909 333766.21658410307 251254.73181781202 261894.24297040576 391946.0592357508 397840.28627671197 323584.84644307895 306779.9432901689 320671.12367437576 1.1998946349724278 1.19761154288829 1.0408365204814158 0.7835277743091943 0.8167066618581635 1.222268019473281 1.2406489294018794 1.0090863272480435 0.9566809127524915 1.0 18.290734919867624 -5.293980028758998 4.967444316375489 1.008915032993717 1.200630716979538 0.23496489415258437 0.13790114686636148 0.300384442179072 19.832979469267435 0.04134592372708035 0.09488942670999134 5.081828110546694e-06 5.293980028758998 0.19171568398582095 RKEEEEEEDDDDDSKEPK ddPTM_A459_Selumetinib_30min_R1 1 RKEEEEEEDDDDDSKEPK 18 3 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3;F5H6N4 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 54.09 0.033224000000000004 9426500.0 3099.9 3969.8 5358.8 5209.0 2590.9 4095.4 3128.2 3616.7 2753.4 3553.0 False True 3172.121638644606 3505.01397049005 4631.104393781371 4299.345935040144 2356.553552460548 4054.2039943256814 2892.237355471731 3520.773367302723 4672.318699620607 4009.0621591507493 0.7912378288783043 0.8742727928250748 1.1551590396798415 1.0724069032521277 0.5878066886744763 1.0112599489314216 0.721424922003305 0.8782037363193536 1.1654393257425464 1.0 11.969049070822091 -8.24747257305411 24.026254378422525 1.0827196516449895 0.8899215169701037 0.19026467861260032 0.16181628596732142 716.6130047532306 1232754.5254861251 0.11334636860883651 0.04229735135544533 5.656234767109578e-09 8.24747257305411 -0.19279813467488582 RKELEEVS(ph)PETPVVPATTQR ddPTM_A459_Selumetinib_30min_R1 3 RKELEEVSPETPVVPATTQR 20 2 Q15149 Q15149 PLEC Plectin 1 RKELEEVS(0.983)PET(0.017)PVVPATTQR;RKELEEVS(0.544)PET(0.456)PVVPATTQR;RKELEEVS(0.878)PET(0.122)PVVPATTQR 112.42 0.00037046 34541100.0 6548.5 6730.7 11248.9 11491.8 8748.3 7150.400000000001 7825.599999999999 7404.9 4437.6 6276.1 True False 6701.067308837121 5942.66651498246 9721.361165784745 9484.972857802712 7957.017809637812 7078.473468043744 7235.308691573297 7208.497997494931 7530.283090519509 7081.698569390937 0.9462514173931365 0.8391583539955104 1.3727442746296998 1.3393641038040494 1.1236030073392629 0.9995445864695325 1.0216911409991813 1.017905228083564 1.0633441986739562 1.0 12.789879721768514 -6.725429479591738 7.958426191490951 1.0217126397543528 1.1345045480714229 0.10527672027281143 0.1497348458624577 0.5902689414353575 111.03550329516875 0.05583331070812226 0.05522586045181746 1.8817872445952973e-07 6.725429479591738 0.11279190831707009 RKELEEVS(ph)PETPVVPATTQR ddPTM_A459_Selumetinib_30min_R2 1 RKELEEVSPETPVVPATTQR 20 2 Q15149 Q15149 PLEC Plectin 1 RKELEEVS(0.752)PET(0.248)PVVPATTQR 79.565 0.0017393 25696000.0 96186.0 86014.0 119560.0 131470.0 108560.0 73907.0 66713.0 78701.0 53663.0 115460.0 True False 90840.36718306561 92610.99722139863 111867.63976708535 113563.55920160032 94921.72226128627 84087.01838905248 69815.2866893016 78930.0068803481 64397.09946949789 112126.3697988932 0.8101606013464488 0.8259519806759391 0.9976925139708714 1.0128175861332605 0.8465602019537 0.7499308016470048 0.6226482388979542 0.703937949849931 0.5743260892598125 1.0 16.774766084464282 -6.731801325743506 3.020449980614192 0.7001264712532055 0.9126881884427557 0.3226686198259133 0.12189346194824557 0.2638919219300649 4.944388460482546 0.043512991920982076 0.04118043919265529 1.854379742089509e-07 6.731801325743506 0.2125617171895502 RKPDTIEVQQMK ddPTM_A459_Selumetinib_30min_R2 2 RKPDTIEVQQMK 12 2 P15311;E7EQR4;P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P15311;P26038;A0A2R8Y5S7 EZR;MSN;RDX Ezrin;Moesin;Radixin 0 ; 89.40299999999998 0.016380000000000002 11477800.0 142485.0 133903.0 143951.0 134801.0 120681.0 104752.0 135816.0 111890.0 110397.0 146051.0 False True 134566.25411264744 144172.9295339934 134689.3493819983 116440.87125530432 105519.9738781714 119180.63715602085 142131.71311429856 112215.58137561324 132479.48474990512 141834.1281439295 0.9487579320549225 1.0164896941284156 0.9496258139318848 0.8209651145254915 0.7439674446413386 0.840281804637876 1.0020981196434406 0.7911747535243412 0.9340451870333244 1.0 17.113845190229192 -5.600650493817794 5.619693567415869 0.8660224795758324 0.9828442875387312 0.22295490051436484 0.08163777926215819 0.261085709259183 13.95331439481 0.022435177081894186 0.039619156631091806 2.5081269006343632e-06 5.600650493817794 0.11682180796289876 RKPS(ph)PEPEGEVGPPK ddPTM_A459_Selumetinib_30min_R1 4 RKPSPEPEGEVGPPK 15 2 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 RKPS(1)PEPEGEVGPPK;RKPS(1)PEPEGEVGPPK;RKPS(1)PEPEGEVGPPK;RKPS(1)PEPEGEVGPPK 149.12 0.00032948 286083000.0 12300.699999999999 15997.2 14327.599999999999 16121.899999999998 13840.1 12539.2 15505.3 14571.0 7466.299999999999 13071.899999999998 True False 12587.282377004316 14124.240387103493 12381.99061587332 13306.512810544004 12588.26539866812 12413.067032682677 14335.722737611348 14184.529746721597 12669.765783023666 14749.80569608856 0.8533863181900956 0.9575882339147723 0.8394680493422939 0.9021483458641562 0.8534529646045675 0.8415749528127306 0.9719262092661315 0.9616757019709848 0.8589784871799029 1.0 13.848408329065567 -7.265822758153783 24.999621389802225 0.9449514086817445 0.8770688265280498 0.3661804915651412 0.0472584340203715 458.0811375288359 2612550.0711894305 0.01889689513249062 0.013218442387329426 5.422221339309382e-08 7.265822758153783 -0.06788258215369469 RKPS(ph)PEPEGEVGPPK ddPTM_A459_Selumetinib_30min_R2 3 RKPSPEPEGEVGPPK 15 2 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 RKPS(1)PEPEGEVGPPK;RKPS(1)PEPEGEVGPPK;RKPS(1)PEPEGEVGPPK 125.86 0.034082999999999995 100881900.0 245801.0 184201.0 207196.0 216419.0 209466.0 148497.0 189426.0 196919.0 138723.0 186557.0 True False 232140.36443936464 198328.6244004334 193865.2349379479 186942.3588564012 183151.00843020054 168951.1138284485 198234.68434049803 197492.00168830468 166471.47624447345 181170.61467670253 1.281335634112724 1.0947063614833408 1.0700699740070918 1.0318580592663897 1.0109310980537987 0.9325525231006163 1.0941878443932322 1.0900884894646272 0.9188657693828572 1.0 17.466989448043343 RKPS(ph)TSDDSDSNFEK ddPTM_A459_Selumetinib_30min_R2 1 RKPSTSDDSDSNFEK 15 2 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 RKPS(0.812)T(0.147)S(0.041)DDSDSNFEK 82.765 0.027991 9984400.0 35160.0 34584.0 36293.0 27801.0 26553.0 26752.0 24088.0 26498.0 16916.0 32393.0 True False 33205.947956631826 37236.48159491304 33957.947892830656 24014.455840600025 23217.17475316814 30436.845169522963 25208.13972946648 26575.104793019967 20299.672672530916 31457.72992287842 1.0555735597590585 1.1836989409662355 1.0794786520223092 0.7633880734393015 0.7380435527321019 0.9675474118489079 0.80133371960617 0.8447877471823724 0.6452999857999121 1.0 14.94112694518002 -5.701855223033037 5.885901444482665 0.8181679023887971 1.1197202026832869 0.6169112042848477 0.10233807005153572 0.12167149586458446 8.350558231301662 0.02711186656745826 0.046997555579715584 1.986757114882395e-06 5.701855223033037 0.30155230029448976 RKPS(ph)VPDSASPADDSFVDPGER ddPTM_A459_Selumetinib_30min_R1 1 RKPSVPDSASPADDSFVDPGER 22 2 C9K098;C9JVV5;H7C5C7;C9J869;C9JAB9;P16333-2;P16333 C9K098 NCK1 Cytoplasmic protein NCK1 1 RKPS(0.99)VPDS(0.01)ASPADDSFVDPGER 65.278 0.0079311 15666000.0 1506.4 1652.6 1721.1 1622.8 1403.4 1556.1 1956.8 2185.1 1128.7 1391.7 True False 1541.4961890558507 1459.112823727104 1487.384073325579 1339.4084437287663 1276.4627177903935 1540.4470468257548 1809.1970005712808 2127.1440497948906 1915.3214630136488 1570.3382513059667 0.9816332167759847 0.9291710384776257 0.9471743250784351 0.8529426336108489 0.8128584505464523 0.980965117257156 1.152106559887125 1.3545769823959 1.219687198869911 1.0 10.6168596341745 -7.246908038152164 3.0930200537107018 1.2196101634229612 0.9057629867385542 0.6563102615230548 0.09397160726819569 0.14312495596021838 2.802499428491979 0.04070557213238683 0.028229370287411484 5.6635920289178424e-08 7.246908038152164 -0.3138471766844071 RKPVLPALTINPTIAEGPS(ph)PTSEGASEANLVDLQK ddPTM_A459_Selumetinib_30min_R2 1 RKPVLPALTINPTIAEGPSPTSEGASEANLVDLQK 35 2 P36507 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 1 RKPVLPALTINPT(0.006)IAEGPS(0.435)PT(0.435)S(0.112)EGAS(0.011)EANLVDLQK 72.57300000000002 9.0099e-06 8430100.0 28578.0 27216.0 27107.0 27018.0 27696.0 21329.0 18037.0 21024.0 17035.0 23638.0 True False 26989.7491667982 29303.379686767068 25362.965131870063 23338.10179135036 24216.580874618496 24266.876144615533 18875.756239637463 21085.17635928944 20442.47599766872 22955.50952110023 1.175741672908187 1.276529264568578 1.1048748496981498 1.0166666860475677 1.054935454704637 1.0571264437545993 0.8222756381115068 0.9185235614094464 0.8905259096461535 1.0 14.486552834052636 -5.910302353013828 0.6644175781034456 0.9087079264168373 1.2651896732618684 0.7186570695985891 0.06814552573102062 0.5574816223702517 0.45112139691708286 0.04082884580319661 0.1239298269100418 1.2294125637161583e-06 5.910302353013828 0.3564817468450311 RKS(ph)ELEFETLK ddPTM_A459_Selumetinib_30min_R2 1 RKSELEFETLK 11 2 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 RKS(0.999)ELEFET(0.001)LK 58.11600000000001 0.04092 3769300.0 33395.0 23215.0 29420.0 30998.0 24824.0 31648.0 30377.0 31926.0 26720.0 32451.0 True False 31539.03959077701 24995.51585200978 27527.149230074054 26776.018925467404 21705.38719062427 36007.22472806003 31789.59069088357 32018.899374366163 32064.746619178677 31514.055312176315 1.0007927979548554 0.7931545338867283 0.8734880026512547 0.8496532312400226 0.6887525891419567 1.1425766811467026 1.0087432536364431 1.0160196476520997 1.0174744666006088 1.0 14.943707795673099 -6.769705312551823 24.999985094468148 1.0362003051284419 0.8407677283065759 0.5911852624392961 0.08140732409485307 130.57963600468162 394930.4881292248 0.027896443282997386 0.025011382527008477 1.6993963747190374e-07 6.769705312551823 -0.195432576821866 RKS(ph)ELPQDVYTIK ddPTM_A459_Selumetinib_30min_R1 2 RKSELPQDVYTIK 13 2 E9PFR3;Q14738-2;Q14738;H0Y8C4;Q14738-3 E9PFR3 PPP2R5D Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 1 RKS(1)ELPQDVYTIK;RKS(1)ELPQDVYTIK 93.427 0.019363 55984000.0 5544.9 6544.0 7445.7 7768.8 7098.8 6361.8 6258.5 7480.6 3642.8 5181.1 True False 5674.085381502781 5777.825437776938 6434.614836302524 6412.124918437295 6456.7147933949345 6297.8060680522385 5786.416306252743 7282.190187586683 6181.565540414746 5846.144653187711 0.9705687625106725 0.9883138000402504 1.10065953171274 1.0968125660286174 1.1044397934755685 1.0772579950819814 0.9897832930113353 1.2456397539899982 1.0573747156673827 1.0 12.513269811352185 -5.22579405948104 5.654243178556335 1.0904285113218652 0.9771618389540653 0.2803348486476104 0.0664314935578178 0.22693331119498955 20.78812800254018 0.016548351230153063 0.043848746724460035 5.945740361511371e-06 5.22579405948104 -0.11326667236779997 RKS(ph)HEAEVLK ddPTM_A459_Selumetinib_30min_R1 1 RKSHEAEVLK 10 2 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 RKS(1)HEAEVLK 90.15 0.011679 14894000.0 3443.3 4919.0 4830.8 4090.5 4363.7 5066.1 2945.0 4319.8 4392.2 3917.0 True False 3523.5221905045237 4343.081193218942 4174.803893684974 3376.1709631948 3969.004105473809 5015.139633650766 2722.8562789668986 4205.224871312054 7453.242606404315 4419.785104811001 0.7972157258662007 0.9826453300843596 0.9445716917640723 0.763876723218916 0.8980083898544049 1.1347021438195521 0.6160607844944836 0.9514546005267555 1.6863359710161816 1.0 12.109760510441616 -8.08624932470533 8.894771592319723 1.3393272165620673 0.8823356885399434 0.4551645287249382 0.2014094623014948 0.31587703388886745 30.276035906924417 0.12643834193673043 0.047640620178958135 8.198807227646423e-09 8.08624932470533 -0.45699152802212395 RKS(ph)HEAEVLK ddPTM_A459_Selumetinib_30min_R2 5 RKSHEAEVLK 10 2 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 RKS(1)HEAEVLK;RKS(1)HEAEVLK;RKS(1)HEAEVLK;RKS(1)HEAEVLK;RKS(1)HEAEVLK 98.407 0.0076688999999999985 74856400.0 377075.0 354703.0 292776.0 366331.0 352662.0 330712.0 486211.0 593699.0 436493.0 614569.0 True False 356118.6810508235 381907.5795500928 273939.1109104062 316436.0858437763 308357.4467217181 376264.57609536743 508820.77490881947 595426.5657978398 523803.7966334261 596824.7961279728 0.5966888161504328 0.6398989821264115 0.45899418503997186 0.5301992944943347 0.516663263192569 0.6304439402257808 0.8525463053980028 0.9976572180995088 0.8776508617465529 1.0 19.18694795055898 -7.282267888889654 2.3662109788669583 0.9532570222398695 0.5479373085356303 0.9156118367374646 0.05603395829492201 0.08291861752754853 0.9114841000065699 0.02782729857281095 0.01802401119375542 5.220740550822139e-08 7.282267888889654 -0.40531971370423925 RKS(ph)LSDSESDDSK ddPTM_A459_Selumetinib_30min_R2 2 RKSLSDSESDDSK 13 2 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 RKS(0.988)LS(0.012)DSESDDSK;RKS(0.627)LS(0.372)DSESDDSK 100.55 0.0042411 21236000.0 162537.0 160069.0 133442.0 150044.0 144777.0 117528.0 150695.0 150971.0 114527.0 224240.0 True False 153503.84422716338 172345.7775970427 124856.48700066445 129607.7483596629 126588.81893719813 133716.41518704014 157702.61609647764 151410.3006154055 137435.60015174665 217765.60855450988 0.7049039802294547 0.7914278969073395 0.5733526419963191 0.5951708776237742 0.5813076719389835 0.6140382591843881 0.7241851325527483 0.695290232559864 0.6311171036786763 1.0 17.732416603488986 -11.685719409144713 0.5540112099606082 1.426790391253006 0.6532230287779751 0.6988533963130081 0.06753312607822634 81.43242584068821 6.269113627569077 43.36731434487335 0.03193227937520031 2.061961684119357e-12 11.685719409144713 -0.7735673624750309 RKS(ph)LVGTPYWMAPELISR ddPTM_A459_Selumetinib_30min_R2 1 RKSLVGTPYWMAPELISR 18 2 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 RKS(0.967)LVGT(0.022)PY(0.011)WMAPELISR 76.051 0.0058409 3989100.0 14844.0 17565.0 18377.0 14611.0 16044.0 10644.0 9279.4 6546.8 6699.5 16429.0 True False 14019.029905240131 18912.179019623156 17194.643827364736 12620.956594619141 14028.409284820169 12110.11438338824 9710.91048678227 6565.850104118912 8039.587199670186 15954.652082331664 0.8786797626734174 1.1853708198730755 1.0777197608969644 0.7910518217188647 0.8792676400857005 0.759033435570751 0.6086569883611705 0.4115320140004806 0.5039023827146505 1.0 13.961689528149908 -6.5204990235381075 1.0417447046707735 0.5870012420951269 1.0477959278787319 0.45946475192962444 0.17307277681023453 0.4038195586994241 0.9386141479387727 0.0852481079569107 0.0990823811933986 3.0164836553760165e-07 6.5204990235381075 0.46079468578360494 RKS(ph)NFSNSADDIK ddPTM_A459_Selumetinib_30min_R2 1 RKSNFSNSADDIK 13 2 P45973 P45973 CBX5 Chromobox protein homolog 5 1 RKS(0.981)NFS(0.017)NS(0.002)ADDIK 61.167 0.035376 7430200.0 56600.0 55245.0 56821.0 54108.0 56703.0 54963.0 52006.0 47164.0 35509.0 62425.0 True False 53454.39858775205 59482.11385932713 53165.19872202711 46738.39705849375 49579.46220874833 62533.654345562594 54424.38204793402 47301.239431579495 42611.792204356854 60622.62805037156 0.8817565372345224 0.9811866587160033 0.876986043525727 0.770972796158864 0.8178375600535261 1.0315233165675886 0.8977568904256774 0.7802571573155279 0.7029024239752616 1.0 15.88756877527207 -7.752209634165092 24.560004090431217 0.8061848453546162 0.8943294678613253 0.07486594410574043 0.09839138540605054 311.0847440687532 827791.6392199709 0.047837673039760074 0.027112599884156142 1.769254732016271e-08 7.752209634165092 0.08814462250670907 RKS(ph)QMEEVQDELIHR ddPTM_A459_Selumetinib_30min_R2 2 RKSQMEEVQDELIHR 15 2 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 RKS(1)QMEEVQDELIHR;RKS(1)QMEEVQDELIHR 141.65 0.00015053 6015100.0 28755.0 25660.6 26187.0 30803.0 30504.0 21553.1 23303.7 26665.0 21127.8 27998.0 True False 27156.91221538533 27628.685508166363 24502.156930249803 26607.578261861152 26671.814810779993 24521.8438854383 24387.368225405527 26742.590735371617 25353.950360055496 27189.62499245978 0.99879686545572 1.0161480901567543 0.9011583255394193 0.9785930578020093 0.9809555967828396 0.9018823868383139 0.8969365422350851 0.9835586457256349 0.9324862099821769 1.0 14.730768632962526 -6.7160578659475965 24.99911857771867 0.9390677237632877 0.9734919909324097 0.13023276393749894 0.04082530982686519 267.15482295596024 147165.58413264807 0.013740254194128753 0.013740200930363553 1.9228355107988803e-07 6.7160578659475965 0.03442426716912195 RKS(ph)YTSDLQK ddPTM_A459_Selumetinib_30min_R2 1 RKSYTSDLQK 10 2 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 RKS(0.514)Y(0.374)T(0.109)S(0.003)DLQK 61.78 0.039111 7020600.0 31756.0 31982.0 31741.0 34571.0 33361.0 20888.0 29117.0 33283.0 23864.0 31581.0 True False 29991.128649340186 34434.9165616617 29698.81861698777 29862.370161698596 29169.892928875917 23765.132397614972 30470.99819424094 33379.84801970274 28637.46681587125 30669.174472707793 0.9778916180488981 1.1227858967089255 0.968360548583284 0.9736933150343787 0.9511143821244333 0.7748866021406392 0.9935382584672043 1.0883843009666643 0.9337540807091321 1.0 14.904501713413612 -5.420067798729464 8.482473391300676 0.957522527589607 1.050155596141678 0.16642655562271758 0.08059190543373349 0.5575090170837249 41.75983224603087 0.022186401440473836 0.04630194928760166 3.8013004869538703e-06 5.420067798729464 0.09263306855207099 RKSLVGTPY(ph)WMAPELISR ddPTM_A459_Selumetinib_30min_R1 1 RKSLVGTPYWMAPELISR 18 2 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 RKS(0.059)LVGT(0.123)PY(0.818)WMAPELISR 81.594 0.01511 53887000.0 3025.3 3587.1 5715.2 6479.0 4705.2 4120.1 3383.6 3174.1 1961.8 2195.6 True False 3095.7836037909356 3167.1206644024505 4939.107231346439 5347.564275892705 4279.61549077053 4078.6555347514895 3128.3723278480115 3089.91255707014 3329.03131579709 2477.4266469550744 1.2495964744691286 1.278391296991601 1.993644186162661 2.1585156850012996 1.7274438765040605 1.6463274663507936 1.2627507384297305 1.247226657898369 1.3437456644331713 1.0 11.274626626578064 -7.250117727642912 3.5746567576223596 1.225268536624585 1.7022094143592177 0.40794761332587304 0.2726964156000158 0.28200242002332576 7.849446059931278 0.13117138656385446 0.09225913208010042 5.6218890753552327e-08 7.250117727642912 0.4769408777346327 RKSLVGTPY(ph)WMAPELISR ddPTM_A459_Selumetinib_30min_R2 1 RKSLVGTPYWMAPELISR 18 2 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 RKS(0.164)LVGT(0.164)PY(0.673)WMAPELISR 72.207 0.029705 3500100.0 10576.0 14340.0 13247.0 13869.0 13118.0 9946.5 5520.1 6217.0 4250.5 11592.0 True False 9988.228259082434 15439.831889632573 12394.702442243068 11980.01827464054 11469.99956359205 11316.540089662833 5776.795587870642 6235.0904407202415 5100.71876889292 11257.308840366954 0.8872660775962906 1.371538447472254 1.101036012958763 1.064199130051586 1.0188935673917394 1.005261581620954 0.5131595543648899 0.5538704257950336 0.45310285444088894 1.0 13.458574359126063 -7.159935667072968 4.024931833328758 0.5929814918169637 1.0965619793835584 0.5940047412720718 0.1795632796320014 0.1475943021489634 4.228323307657318 0.069308393174541 0.05246716503648522 6.919334608419774e-08 7.159935667072968 0.5035804875665947 RLAAAEETAVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 RLAAAEETAVSPR 13 1 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 1 RLAAAEET(0.001)AVS(0.999)PR;RLAAAEET(0.001)AVS(0.999)PR;RLAAAEETAVS(1)PR;RLAAAEET(0.017)AVS(0.983)PR;RLAAAEETAVS(1)PR;RLAAAEETAVS(1)PR;RLAAAEETAVS(1)PR 151.07 0.00085382 152370100.0 14876.000000000002 14957.5 15513.300000000003 16995.4 16081.1 14122.2 15359.3 14781.3 8679.489999999998 12040.6 True False 15222.581856342838 13206.268946446904 13406.679068457212 14027.472433169753 14626.567344348792 13980.143489931677 14200.735635156623 14389.251907570922 14728.460605131851 13586.128295375875 1.1204503244330426 0.9720406475877121 0.9867917317562989 1.0324849087391654 1.0765809821865908 1.029001286164058 1.0452378577927852 1.0591135012664643 1.084080783349056 1.0 13.729846762448291 -6.005763023793013 24.887859723744608 1.051111899969901 1.0190971166848222 0.04667626376682443 0.04297194302864438 580.0406442838107 2504963.7701583025 0.011975097843556931 0.017121985721739626 9.868178036613897e-07 6.005763023793013 -0.032014783285078785 RLAAAEETAVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 RLAAAEETAVSPR 13 1 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 1 RLAAAEETAVS(1)PR;RLAAAEETAVS(1)PR;RLAAAEETAVS(1)PR;RLAAAEETAVS(1)PR;RLAAAEETAVS(1)PR 135.57 0.00058536 192301700.0 363393.0 335514.0 373623.0 416511.0 389860.0 261730.0 255232.0 238114.0 290369.0 342149.0 True False 343197.0718374376 361246.8449524533 349584.5029499648 359781.483278448 340882.3014073789 297780.93175161676 267100.7937326137 238806.87231810536 348450.913587736 332270.26936013746 1.0328852849168304 1.0872078493454045 1.0521088860076764 1.0827976995091666 1.025918756029018 0.8962009520895811 0.8038660643547118 0.7187127297846501 1.048697237519198 1.0 18.341997684813805 -6.740892527223641 3.335586423722039 0.8669355864236272 1.0635444436280603 0.4498356195027162 0.0888020620307864 0.19413184680702106 4.497133424611242 0.031221030447142 0.02946136149362964 1.815964995337664e-07 6.740892527223641 0.1966088572044331 RLAAQES(ph)SETEDMSVPR ddPTM_A459_Selumetinib_30min_R1 1 RLAAQESSETEDMSVPR 17 1 F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 F8W7U3 FAM21A WASH complex subunit FAM21A 1 RLAAQES(0.48)S(0.48)ET(0.04)EDMS(0.001)VPR 78.418 0.0096567 6354800.0 808.64 695.13 1072.1 974.93 1090.1 874.9 878.36 815.68 387.93 709.36 True False 827.4797386604646 613.7438564428303 926.5147086237602 804.6767772026664 991.5006474727861 866.0993003456418 812.104598028307 794.0455166979528 658.2888767138165 800.4132657515271 1.0338156225878192 0.766783713743889 1.1575454184331058 1.0053266376677754 1.2387359004374352 1.0820651498478608 1.014606619826325 0.9920444233922142 0.8224362399787732 1.0 9.644601267907115 -7.976921558524877 3.470604079698305 0.9087226182184454 1.043754833686569 0.15283398347009414 0.12163162745902831 0.446904849335245 11.137376840774452 0.0858163451420689 0.033676934554896155 1.0545773550239453e-08 7.976921558524877 0.1350322154681236 RLAS(ph)TSDIEEK ddPTM_A459_Selumetinib_30min_R1 2 RLASTSDIEEK 11 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RLAS(0.372)T(0.372)S(0.255)DIEEK;RLAS(0.434)T(0.434)S(0.132)DIEEK 121.92 0.0077230000000000016 28034000.0 3862.3 4853.1 4020.6 4720.2 3770.8 5816.200000000001 9770.9 12597.7 10227.1 3219.6 True False 3952.284075272447 4284.896795855023 3474.6246035749396 3895.9056791277585 3429.7318057888115 5757.694308687074 9033.873146403284 12263.568072903341 17354.641742169642 3632.867021559736 1.0879242349959655 1.1794807710895359 0.9564414505002012 1.072405253483539 0.944084048613563 1.5848899160132386 2.4867062550846355 3.3757272149306745 4.777120009947019 1.0 11.826892842585183 -7.324116106761497 2.0966515854799272 3.2823302876660034 1.0617575753786939 0.504902006162937 0.8717108546151948 0.23809903817467726 2.04326413862167 0.4288109672951561 0.26226645234078233 4.741152156519808e-08 7.324116106761497 -2.22057271228731 RLAS(ph)TSDIEEK ddPTM_A459_Selumetinib_30min_R2 1 RLASTSDIEEK 11 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RLAS(0.767)T(0.207)S(0.026)DIEEK 122.66 0.0073388 21860000.0 52102.0 50405.0 47114.0 47686.0 49208.0 31695.0 53612.0 80844.0 79735.0 144060.0 True False 49206.37942083138 54270.90142238006 44082.73653384463 41191.08453706171 43026.051114898444 36060.698551436515 56105.064230162614 81079.24265555541 95684.22798204365 139900.6134871691 0.35172382875464886 0.38792468502904376 0.3151003804417745 0.2944310500885654 0.3075472654653123 0.2577594025686228 0.4010351551125132 0.5795488714064256 0.6839443058683891 1.0 17.09404276340807 -8.326312949140926 1.0475899384861316 0.9895424593522546 0.3168286343465702 0.9599391034494844 0.044257918143559484 0.0930055112160382 0.2151349917764948 0.04562988643576037 0.015338642389601758 4.717229989305387e-09 8.326312949140926 -0.6727138250056843 down RLDAAYR ddPTM_A459_Selumetinib_30min_R2 2 RLDAAYR 7 1 Q9Y5A9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q9Y5A9-2;Q7Z739 Q9Y5A9 YTHDF2;YTHDF3 YTH domain-containing family protein 2;YTH domain-containing family protein 3 0 ; 118.74 0.018714 949690.0 7863.6 5338.6 8195.7 9184.900000000001 8580.5 7635.200000000001 5128.1 5316.0 6306.9 7175.5 False True 7426.572592484924 5748.0534536954265 7668.397584803466 7933.90077516374 7502.540879356731 8686.879494555236 5366.566811137376 5331.468679888822 7568.456229509655 6968.324670812028 1.065761562975437 0.8248831283324229 1.1004650252482937 1.1385664632413277 1.0766635071959771 1.2466238163301515 0.7701373091320103 0.7651004985775928 1.0861227894864567 1.0 12.766596128756486 -7.273925851072125 24.98735498140402 0.8857652005699704 1.0681576714734762 0.27506980855239327 0.13350449016857727 1031.9052828868337 2064993.6221409806 0.05739954854578479 0.03900638347409531 5.321991161092253e-08 7.273925851072125 0.18239247090350574 RLDDQES(ph)PVYAAQQR ddPTM_A459_Selumetinib_30min_R2 1 RLDDQESPVYAAQQR 15 1 Q96ST3;H3BMA2;H3BT34;H3BQ76;H3BQ88;H3BNA0;H3BNZ3;H3BQL7;H3BP90 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 RLDDQES(1)PVYAAQQR 107.73 0.01455 0.0 16728.0 16281.0 16305.0 19474.0 16629.0 12733.0 13065.0 12985.0 14183.0 13297.0 True False 15798.324727489678 17529.700348333892 15255.954051541723 16821.607605476223 14539.916354853814 14486.855171334326 13672.548387806357 13022.78420021753 17019.996306130644 12913.081060244946 1.223435727986517 1.3575149312972232 1.1814340807098083 1.3026796259542057 1.125983511372615 1.1218744081096574 1.0588137969566038 1.00849550463292 1.3180430159715728 1.0 13.656545648203997 -6.349448811693157 4.720938885815902 1.1019161241122584 1.2665694979924433 0.41692066977644415 0.09329255962832468 0.2201381356714315 8.476820814784553 0.028314598034975637 0.03240328070883491 4.472508640986412e-07 6.349448811693157 0.16465337388018497 RLDEEEEDNEGGEWER ddPTM_A459_Selumetinib_30min_R1 3 RLDEEEEDNEGGEWER 16 1 Q99613-2;Q99613 Q99613-2 EIF3C Eukaryotic translation initiation factor 3 subunit C 0 ;; 284.91 6.432699999999995e-150 75749000.0 4222.72 4975.49 5971.06 6665.57 5386.58 5031.21 4931.77 4679.85 2989.04 3745.2400000000002 False True 4321.10116001721 4392.957317757454 5160.222848684814 5501.55332774535 4899.364790077939 4980.600595373182 4559.762618309196 4555.725175704827 5072.182569155949 4225.978035726918 1.022509138354745 1.0395125768801619 1.2210718572268193 1.3018414391259412 1.1593445939988636 1.1785675536565963 1.0789839842423277 1.078028597685598 1.200238743854113 1.0 12.045069553631533 -7.263189304378386 24.379320431604942 1.0958152140193171 1.158650542954282 0.11006902177241662 0.08843644273398127 301.6538949395195 4202476.812130408 0.03879950235594599 0.02769339912630826 5.4552002284233855e-08 7.263189304378386 0.0628353289349648 RLDEEEEDNEGGEWER ddPTM_A459_Selumetinib_30min_R2 1 RLDEEEEDNEGGEWER 16 1 Q99613-2;Q99613 Q99613-2 EIF3C Eukaryotic translation initiation factor 3 subunit C 0 168.1 1.8414e-05 42394000.0 14278.0 12941.0 14763.0 17827.0 18426.0 13849.0 13489.0 12302.0 10693.0 17242.0 False True 13484.485919362602 13933.533088126582 13813.164652739066 15398.931846709711 16111.16114946998 15756.574041294973 14116.265227946424 12337.796783294265 12831.898787383141 16744.178659903988 0.8053238198928727 0.8321419265247184 0.8249532529067193 0.9196588354366024 0.9621947708937287 0.941018031480161 0.8430551008004693 0.7368409662779488 0.7663498489842749 1.0 14.031371989852364 -10.276762436981528 9.291878999152768 0.9999996115435357 0.8516021336543499 0.2985782040677414 0.06971321469713514 0.0 0.0 0.07748600886268692 0.01879311759108261 5.2873439519307273e-11 10.276762436981528 -0.14839747788918578 RLDEELEDAEK ddPTM_A459_Selumetinib_30min_R2 2 RLDEELEDAEK 11 1 Q15008-4;C9J0E9;Q15008;C9J7B7;Q15008-3;Q15008-2 Q15008-4 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 ; 160.86 0.00081818 10416600.0 77548.0 75511.0 81433.0 78539.0 74026.0 57684.0 64735.0 66955.0 51032.0 70754.0 False True 73238.19260924027 81302.45089386664 76193.68943754665 67841.85271266816 64726.192079163404 65629.44739678386 67745.30576996904 67149.82796500299 61239.82595321576 68711.14817903072 1.0658851518302983 1.183249778944584 1.1088985041993442 0.9873485527545318 0.942004227763968 0.9551499157863391 0.985943439534075 0.9772770466597411 0.8912647740022039 1.0 16.06825657055481 -5.779062307408105 3.603558741095939 0.9591582284894784 1.1297395564111967 0.7811512406376873 0.03826675931450326 0.09223851997379026 2.5358141458041246 0.010511267364027885 0.0175876996963365 1.6631740208208664e-06 5.779062307408105 0.17058132792171832 RLDEVSR ddPTM_A459_Selumetinib_30min_R2 2 RLDEVSR 7 1 Q9P2E9;A0A087WVV2;Q9P2E9-3;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 ; 148.99 0.0036287 3725300.0 11217.7 8568.7 12581.5 14398.0 11338.6 8917.7 10177.7 13706.8 10032.6 12379.8 False True 10594.265142011058 9225.89173728693 11772.019987701444 12436.967562064629 9914.143699629883 10146.032228179378 10650.983216729957 13746.68451871711 12039.400334265409 12022.363007416738 0.8812132136981167 0.7673942079103224 0.9791768873090212 1.0344861117895139 0.8246418523142024 0.8439299513681437 0.8859309280679047 1.143426172561635 1.0014171362849518 1.0 13.553432866615923 -7.7413166488804235 24.997532294883502 1.054316222526239 0.8884595130970626 0.45648927866605205 0.08000866045400136 209.40799588769664 260138.35709815254 0.03966618234329882 0.02286399400048513 1.814192432797045e-08 7.7413166488804235 -0.1658567094291764 RLDLPIER ddPTM_A459_Selumetinib_30min_R2 1 RLDLPIER 8 1 B4E1E0;P17812-2;P17812;A0A3B3IRI2;A0A3B3ISY3;A0A3B3ITB8;A0A3B3IRQ8;A0A3B3ITF6 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 0 102.06 0.022363 3062500.0 9237.5 10725.0 11860.0 11262.0 12956.0 8810.2 8357.0 10107.0 7755.2 10052.0 False True 8724.116730642394 11547.57301368963 11096.94051219164 9728.096171966377 11328.351451890425 10023.725078967222 8745.61705908134 10136.409696696077 9306.45669839275 9761.772641767473 0.8937021021484065 1.1829381237871996 1.1367751451935497 0.9965501685977601 1.1604809769303648 1.0268345152886411 0.8959046046269986 1.0383779738247183 0.953357247696328 1.0 13.252927435449788 -6.999928226883209 24.9999996207065 0.9731454644258948 1.0807459318491826 0.2385326800655042 0.08564384703001544 3.4714228109456853 1208440.5333999915 0.02918925465716548 0.02548743577221641 1.0001652773656002e-07 6.999928226883209 0.10760046742328777 RLDS(ph)SACLHAVGDK ddPTM_A459_Selumetinib_30min_R2 1 RLDSSACLHAVGDK 14 1 E5RJP4;O94808 E5RJP4 GFPT2 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 1 RLDS(0.5)S(0.5)ACLHAVGDK 60.093 0.046596 5663200.0 28003.0 25332.0 42488.0 33317.0 44617.0 44653.0 21708.0 32180.0 25038.0 48084.0 True False 26446.705364890808 27274.88294478189 39754.36833743666 28779.167124969277 39011.8135789592 50803.54543042419 22717.465013585945 32273.638472314196 30046.299620171972 46695.68998276437 0.5663628779155513 0.5840985100519811 0.8513498430392656 0.6163131358716794 0.8354478452584952 1.0879707623803405 0.4865002534917266 0.6911481227545105 0.6434490984341857 1.0 15.511001774721088 -5.223796351341357 13.358704542399703 0.7626346440206762 0.5751585854527902 0.17788204529721852 0.17102368534472537 4.873952741873091 1723.9796150984128 0.04371980539808058 0.1154183703400833 5.97315313044271e-06 5.223796351341357 -0.18747605856788596 RLEAAYLDLQR ddPTM_A459_Selumetinib_30min_R1 2 RLEAAYLDLQR 11 1 E5RIW3;E5RJD8;E5RHG6;O75347;O75347-2 E5RIW3 TBCA Tubulin-specific chaperone A 0 ; 118.87 0.007015899999999999 22246000.0 4133.0 4861.2 4693.4 5572.1 5049.5 4611.2 4045.8 4481.5 2862.5 3604.8 False True 4229.2908585819405 4292.0484440894315 4056.062059000798 4599.037336271297 4592.773616561634 4564.815514634611 3740.622048707732 4362.6360620364285 4857.45343127188 4067.5111937254787 1.0397736249886718 1.0552026139990278 0.9971852235484091 1.1306760122420185 1.1291360730970876 1.1222625574273208 0.9196341129873216 1.072556621052748 1.1942077599601844 1.0 11.989930600838935 -5.751418756688547 24.99954815607967 1.0812087022356742 1.033168714079339 0.09022619375602703 0.07334729183969983 597.105677121529 1489651.1616604638 0.02079726020014364 0.03549143014643697 1.7724795912382892e-06 5.751418756688547 -0.048039988156335145 RLEEEADR ddPTM_A459_Selumetinib_30min_R2 1 RLEEEADR 8 1 A0A669KAX4;Q13620-1;K4DI93;Q13620;Q13620-3 A0A669KAX4 CUL4B Cullin-4B 0 94.309 0.030904 1808300.0 12605.0 16325.0 13116.0 14452.0 15713.0 9943.2 13586.0 18985.0 10941.0 16911.0 False True 11904.464561812967 17577.075006851577 12272.130839621053 12483.612668909434 13738.992463997714 11312.785544617243 14217.775920148275 19040.24320686405 13129.505717082104 16422.73548994527 0.7248770808676429 1.0702891133826666 0.7472647201274476 0.7601421015733011 0.8365836783043444 0.688849038063326 0.8657373754118509 1.1593831745339462 0.7994713015453834 1.0 14.003406832431502 -7.537008815720502 24.980940686620883 0.9901684598683941 0.8105367901243953 0.2886774330582419 0.12725323929975885 298.4679679372537 527663.010502747 0.057694693356731545 0.03332863604853041 2.9039637064619215e-08 7.537008815720502 -0.1796316697439988 RLEEPSLR ddPTM_A459_Selumetinib_30min_R1 1 RLEEPSLR 8 1 O00429-4;O00429-5;O00429-3;O00429-9;O00429-2;O00429;O00429-8;O00429-6;O00429-7 O00429-4 DNM1L Dynamin-1-like protein 0 109.48 0.013802000000000002 0.0 513.01 855.08 1121.9 1113.4 882.36 844.77 1056.2 676.76 373.66 613.78 False True 524.9621348563077 754.966836084093 969.5521421555794 918.9655911064887 802.550693793311 836.2723807897898 976.5299836485016 658.8101263737083 634.0737289533798 692.5646417234865 0.7579973091752267 1.0901030612901563 1.3999446170725578 1.3269022640537793 1.1588097997554683 1.2075008315594606 1.4100199819880368 0.9512615670563571 0.9155444715968336 1.0 9.435804923668046 -7.811111489199632 21.039840345555714 0.950045560006483 1.2014263928720175 0.273310452771225 0.17698235797928763 32.691682910278104 13845.312064935579 0.10143589534584813 0.048728955030059196 1.5448578029782505e-08 7.811111489199632 0.2513808328655345 RLEEQAAQHK ddPTM_A459_Selumetinib_30min_R2 2 RLEEQAAQHK 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 103.26 0.009728 2716200.0 22436.0 17406.5 18416.4 18290.6 20818.0 14763.6 22593.0 33921.0 22566.0 31360.0 False True 21189.096938424114 18741.522579280983 17231.508874260213 15799.38872695509 18202.65672471866 16797.151889382807 23643.619267180176 34019.70449407614 27079.830546721 30454.55531693475 0.6957611666929043 0.6153930794339806 0.5658105559229214 0.5187857304936442 0.5976989824769097 0.5515480923815189 0.7763573961637442 1.1170645619362871 0.88918817775884 1.0 14.894370418571704 -7.528514352100248 3.911764840706269 1.0005533754324958 0.5902597386464222 0.8784421757099465 0.06844214790413804 0.06790348465246979 2.357979726191873 0.03289992862149148 0.019208313881592436 2.9613221011669586e-08 7.528514352100248 -0.41029363678607356 RLEQTSVRDPS(ph)PEADAPVLGSPEK ddPTM_A459_Selumetinib_30min_R2 2 RLEQTSVRDPSPEADAPVLGSPEK 24 2 O15234 O15234 CASC3 Protein CASC3 1 RLEQT(0.041)S(0.041)VRDPS(0.917)PEADAPVLGS(0.001)PEK;RLEQT(0.052)S(0.052)VRDPS(0.895)PEADAPVLGS(0.001)PEK 49.125 0.018452 12446700.0 53294.0 51459.0 61135.0 70068.0 63474.0 47335.0 57927.0 56892.0 50441.0 48494.0 True False 50332.13283278543 55405.73983323588 57201.640658755154 60524.61752595818 55499.82865524027 53854.966585652226 60620.72028017292 57057.546301022376 60530.60943929603 47093.85221745644 1.0687622792116513 1.1764962351646069 1.214630741919898 1.2851914777853597 1.1784941354758818 1.1435668149841778 1.2872321423241404 1.2115710143557263 1.2853187112363456 1.0 15.52325111764056 -11.787089996278562 2.4878799458483725 0.05789718174226295 1.2073815654134108 0.465750884255819 0.06606876365964352 3266473.193962691 1823956.6118324217 18457380.972825974 0.017136815755355934 1.6327135752521138e-12 11.787089996278562 1.149484383671148 RLFDDEAS(ph)VDEPR ddPTM_A459_Selumetinib_30min_R1 4 RLFDDEASVDEPR 13 1 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35;Q8NI35-5 A0A0U1RR46 INADL InaD-like protein 1 RLFDDEAS(1)VDEPR;RLFDDEAS(1)VDEPR;RLFDDEAS(1)VDEPR;RLFDDEAS(1)VDEPR 238.83 1.8794e-17 38264100.0 8146.700000000001 8080.599999999999 10337.3 9985.8 9812.8 7878.5 9073.900000000001 8639.3 4853.55 6568.0 True False 8336.502259281271 7134.519595430976 8933.551438724367 8241.96748668149 8925.23397259055 7799.249443105652 8389.4484175612 8410.15769959864 8236.119860733497 7411.066777737721 1.124872101317922 0.9626845647731211 1.205433941785557 1.112116208619214 1.2043116382922456 1.0523787839200156 1.1320163033427877 1.1348106759558707 1.111327168913681 1.0 12.855465509268674 -5.261612446600006 24.99989153649763 1.124743489997063 1.0437783411676376 0.15698932706558277 0.06876461466506245 23.051974084720303 3330777.7520729396 0.016442170163800073 0.03820220758013099 5.475043239577862e-06 5.261612446600006 -0.0809651488294254 RLFDDEAS(ph)VDEPR ddPTM_A459_Selumetinib_30min_R2 2 RLFDDEASVDEPR 13 1 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35;Q8NI35-5 A0A0U1RR46 INADL InaD-like protein 1 RLFDDEAS(1)VDEPR;RLFDDEAS(1)VDEPR 149.19 0.00027005 15824000.0 36168.0 36167.0 34574.0 38432.0 32806.0 28913.0 24023.0 26660.0 26737.0 35688.0 True False 34157.92735197553 38940.89260476575 32349.546481324953 33197.49530110212 28684.61699063887 32895.503303918114 25140.117100671436 26737.576186199425 32085.147094198328 34657.59471144028 0.9855827456110272 1.123589012133943 0.9334042581623977 0.9578707229253798 0.8276574652530702 0.9491571350466365 0.7253855124681466 0.7714781250348426 0.9257753563494467 1.0 15.080883912342708 -5.7878595302772915 1.30649233939948 0.849593247247222 1.0543131287196674 0.3721153931929261 0.0879189319717045 0.4344454545274007 1.4808217344379395 0.029860124245177283 0.0720153132844521 1.629823103068144e-06 5.7878595302772915 0.20471988147244546 RLGDS(ph)SLSR ddPTM_A459_Selumetinib_30min_R2 1 RLGDSSLSR 9 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 RLGDS(0.5)S(0.5)LSR 93.442 0.044108 8366700.0 56498.0 62234.0 65612.0 66906.0 63791.0 46723.0 40408.0 37404.0 28961.0 57906.0 True False 53358.06733941368 67007.14768615011 61390.59535294417 57793.28738071231 55777.00428122434 53158.66914083511 42287.05206693298 37512.83944743445 34754.009237950326 56234.10332214361 0.9488560177397296 1.1915749292256315 1.0916968836732577 1.027726663473884 0.9918714976515101 0.9453101587894002 0.7519823304496682 0.6670834463659496 0.6180237113208321 1.0 15.779157701664184 -7.02954735101028 1.663933375389742 0.7240634859345867 1.069439187255079 0.594665187004936 0.11230250161051082 0.2303225493159984 1.2817093550487093 0.053054427764442094 0.039090230940307696 9.34227504131389e-08 7.02954735101028 0.34537570132049233 RLGDSSLS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RLGDSSLSR 9 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 RLGDS(0.119)S(0.119)LS(0.762)R 72.289 0.034839 22655000.0 22704.0 24254.0 34790.0 31390.0 27244.0 24982.0 23850.0 15525.0 17074.0 34497.0 True False 21442.202571313122 26114.20381109821 32551.649276487966 27114.627849229677 23821.365155549778 28423.043735983185 24959.072257878433 15570.175179697888 20489.277087419767 33500.98197602989 0.6400469868810149 0.7795056225451256 0.9716625411093568 0.8093681513165888 0.7110646837932714 0.8484241971271171 0.7450250943610179 0.46476772504275904 0.6116022838399167 1.0 15.031915763811963 -7.534210873951457 24.984529445193186 0.6438902634445313 0.7977194673846494 0.056811518381917114 0.15020179858587734 389.6585484176455 859088.4854423363 0.06840678710578191 0.039537091272347225 2.922732885049559e-08 7.534210873951457 0.15382920394011812 RLGDSSLSR ddPTM_A459_Selumetinib_30min_R2 2 RLGDSSLSR 9 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 ; 134.84 0.0037683 2624200.0 10018.6 11630.5 13252.2 14542.5 13278.8 10147.4 6678.6 8562.3 6995.7 12634.900000000001 False True 9461.806319633437 12522.52195204823 12399.567879904398 12561.786412788228 11610.59843002182 11545.112241074208 6989.16813339484 8587.214875434931 8395.035476189674 12270.09760758733 0.7711272250827605 1.0205723175588115 1.0105516904964968 1.023772329652906 0.946251513341043 0.9409144580834614 0.5696098235659529 0.6998489457919997 0.6841865276604259 1.0 13.582859105112785 -7.155036460062083 7.2168378266308935 0.7140179735778477 0.9626383757024034 0.4158473655029227 0.12257265351554297 0.22003796801925785 13.12548656992397 0.044975728328391355 0.03479228148136877 6.997832450564547e-08 7.155036460062083 0.24862040212455572 RLGGLRPES(ph)PESLTSVSR ddPTM_A459_Selumetinib_30min_R1 1 RLGGLRPESPESLTSVSR 18 2 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 RLGGLRPES(0.893)PES(0.043)LT(0.043)S(0.016)VS(0.004)R 84.113 0.0092663 101880000.0 1133.5 631.66 4294.7 4650.8 2193.2 2050.0 1030.6 1182.2 1179.0 895.49 True False 1159.908344592942 557.7049535492329 3711.5033290984666 3838.625086328415 1994.8254472409096 2029.3788612510753 952.8610122591795 1150.844215673205 2000.676889247002 1010.4348643112595 1.147929852344879 0.5519454773855018 3.6731742541646466 3.798983211990541 1.9742246805791268 2.0084212579445744 0.9430207190135665 1.138959329612654 1.9800156941444405 1.0 9.980760608889492 -7.054418413459839 3.3269180420046607 1.2806866033328554 2.292607744695174 0.18053327054067492 0.9665549428660973 0.4910021993730609 10.816283508371637 0.4321371103041822 0.33913964968819515 8.822295221650568e-08 7.054418413459839 1.0119211413623184 RLGGLRPES(ph)PESLTSVSR ddPTM_A459_Selumetinib_30min_R2 1 RLGGLRPESPESLTSVSR 18 2 Q9H6F5;H0YG79 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 1 RLGGLRPES(0.947)PES(0.032)LT(0.018)S(0.004)VSR 90.729 0.0063716 13172000.0 18727.0 38217.0 27364.0 32705.0 23456.0 11976.0 4622.4 5131.5 3954.3 27791.0 True False 17686.228310120707 41148.12101297682 25603.43003167051 28250.522580728146 20509.247580699426 13625.585292696125 4837.350759111835 5146.431815434443 4745.270492373436 26988.601620310394 0.6553221452129945 1.5246481307875772 0.9486756813810809 1.0467575526205881 0.7599225728414584 0.5048644418257717 0.17923680623272698 0.19068908748356464 0.17582498564143323 1.0 14.72006260690227 -6.618462002751695 1.7831546439773234 0.32015816903203337 1.0813187173915897 0.4872341660941989 0.3039002192986074 0.2559278525052724 1.6679105250542592 0.11416009552020613 0.11598122341636122 2.4073431328552135e-07 6.618462002751695 0.7611605483595563 RLGS(ph)VEAPK ddPTM_A459_Selumetinib_30min_R2 2 RLGSVEAPK 9 1 P46087-2;P46087;P46087-4;P46087-3;F5H359;F5GWB7;F5H709;F5H5X6 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 RLGS(1)VEAPK;RLGS(1)VEAPK 79.744 0.024727 12938500.0 52044.0 52072.0 55647.0 53272.0 45180.0 38749.0 45051.0 47475.0 46518.0 60317.0 True False 49151.60282863898 56065.75496213018 52066.73260387252 46016.26170067424 39504.08448567531 44086.32302160004 47145.96076686295 47613.14439009068 55822.899821517676 58575.49148761325 0.8391155000215899 0.9571538119144285 0.8888825561947336 0.7855889986071244 0.6744131970967601 0.7526411115290909 0.8048752058159466 0.8128509583254502 0.9530077922320522 1.0 15.838009533866499 -10.198485993873234 7.131513902596419 1.0000000000624842 0.8259409774910295 0.27578615752211577 0.08250753287945656 6.488794107951698e-11 0.0 0.08881975747737166 0.021541955555849923 6.331607810058636e-11 10.198485993873234 -0.17405902257145478 RLLDDISNGYDDS(ph)EDGGHTLGDPSYSYETTEK ddPTM_A459_Selumetinib_30min_R1 1 RLLDDISNGYDDSEDGGHTLGDPSYSYETTEK 32 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 RLLDDISNGY(0.008)DDS(0.839)EDGGHT(0.153)LGDPSYSYETTEK 85.19 2.2675e-07 18634000.0 2299.9 2079.9 2440.9 2711.3 2436.7 1953.2 2133.5 2247.7 1513.6 1661.1 True False 2353.4831951736273 1836.384341080722 2109.439186903961 2237.8223524043656 2216.3009152343247 1933.5525813637057 1972.568377309295 2188.0836944414314 2568.468651029909 1874.3183654841844 1.2556475135245566 0.9797611627234613 1.1254433749087438 1.1939392974076093 1.1824570233359462 1.031603070732447 1.0524190626493328 1.1674023659668902 1.3703481213910038 1.0 10.872150309855058 -7.997329399534774 24.89431057280569 1.213074445906624 1.1141727366188225 0.048575356169642814 0.11401800449531782 155.8015574735027 1452328.4792882155 0.060211185564478284 0.02864968548566371 1.0061682304866657e-08 7.997329399534774 -0.09890170928780151 RLLEDGEDFNLGDALDSS(ph)NSMQTIQK ddPTM_A459_Selumetinib_30min_R1 1 RLLEDGEDFNLGDALDSSNSMQTIQK 26 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 RLLEDGEDFNLGDALDS(0.16)S(0.596)NS(0.241)MQT(0.003)IQK 140.74 1.0544e-09 25246000.0 1005.9 1392.9 1844.8 2373.5 1440.3 1208.6 1118.8 1020.6 533.88 901.19 True False 1029.3355128593207 1229.818620458358 1594.2862927610422 1959.0127811130305 1310.0251193056188 1196.4425813209996 1034.408015248953 993.5303726239827 905.9553669475736 1016.8665148339608 1.0122621778212413 1.209419921413352 1.5678422580581932 1.9265191178341714 1.2882960547870204 1.1765974824299932 1.0172505438610657 0.9770509286424988 0.8909285080505406 1.0 9.989914592150017 -6.94027846069136 2.1572502684390136 0.9682515240848082 1.4331805746358595 0.44916171236059255 0.22572756098383664 0.3218767429708682 3.0369833648497737 0.10616342545316228 0.08671192653630289 1.1474176849632638e-07 6.94027846069136 0.46492905055105127 RLLEDGEDFNLGDALDSSNSMQTIQK ddPTM_A459_Selumetinib_30min_R1 2 RLLEDGEDFNLGDALDSSNSMQTIQK 26 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 186.69 9.6718e-27 98230000.0 4053.5 3302.5 6680.0 7415.4 4952.5 4697.5 4158.8 3871.7 2383.39 2855.2799999999997 False True 4147.938663262011 2915.8417647094034 5772.892690613491 6120.4395942976935 4504.547249434894 4650.247414988743 3845.0983677309123 3769.0099389459856 4044.438754081778 3221.7830007824223 1.2874668040195967 0.9050397758015608 1.7918316314945861 1.8997057197245504 1.3981535219289902 1.4433769791011415 1.193469071876385 1.1698522023459268 1.2553417635823303 1.0 11.653643611034983 -7.270038804895238 3.0990787592578606 1.1601192719351474 1.4666091373727301 0.24087082949341942 0.26084894098780154 0.4579450056896289 9.023392311298757 0.12872645132450145 0.08760012280344243 5.3698381387801695e-08 7.270038804895238 0.3064898654375827 RLLGPAPEDDGGHNDHSQPQASQDQDS(ph)HTLSPQV ddPTM_A459_Selumetinib_30min_R2 1 RLLGPAPEDDGGHNDHSQPQASQDQDSHTLSPQV 34 1 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 RLLGPAPEDDGGHNDHS(0.017)QPQAS(0.107)QDQDS(0.292)HT(0.292)LS(0.292)PQV 40.129 0.029981 12700000.0 24847.0 21442.0 30865.0 27454.0 32843.0 23094.0 24576.0 26876.0 18235.0 28464.0 True False 23466.10321042181 23086.532453103326 28879.179503271094 23714.717839208406 28716.968719854685 26274.988873540795 25718.83269642014 26954.204710438684 21882.509528470167 27642.17036164638 0.848924049863361 0.8351924668381315 1.0447507965344527 0.8579180841788266 1.03888256038316 0.9505400093328941 0.9304201645506506 0.9751117353591652 0.7916349997911972 1.0 14.754583274836293 -5.2157004498894795 24.78887513567321 0.9471660140645763 0.8420581227920134 0.25153165950602063 0.0735175420789068 521.9870401723069 282896.37702049915 0.017565247479483584 0.046473024651596986 6.085546007734175e-06 5.2157004498894795 -0.10510789127256293 RLNHS(ph)PPQSSSR ddPTM_A459_Selumetinib_30min_R1 3 RLNHSPPQSSSR 12 1 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6 A0A087X0H9 RBM26 RNA-binding protein 26 1 RLNHS(0.996)PPQS(0.003)SSR;RLNHS(0.784)PPQS(0.131)S(0.08)S(0.004)R;RLNHS(0.99)PPQS(0.002)S(0.008)SR 130.66 0.0010966 67725600.0 4343.76 4740.58 5664.55 6447.16 5858.46 4759.46 5179.12 4527.1900000000005 2439.63 3486.3599999999997 True False 4444.961156514371 4185.550689764146 4895.335223145902 5321.284534181882 5328.56332739512 4711.584153643921 4788.454808666566 4407.114214814391 4139.873926474693 3933.868266022179 1.1299212012020412 1.06397835583764 1.2444075124294725 1.3526849844320337 1.354535273440465 1.1976974913824827 1.2172382207166592 1.1203004058066097 1.0523671985236103 1.0 11.941732931363779 -8.06827128519384 1.6009438261122997 1.0073011075451854 1.2293790784027598 0.4787076963225815 0.08354914086165936 0.39016887287769875 1.7871561967858336 0.08692719800938511 0.02798871385906111 8.545327560563509e-09 8.06827128519384 0.2220779708575744 RLNHS(ph)PPQSSSR ddPTM_A459_Selumetinib_30min_R2 3 RLNHSPPQSSSR 12 1 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6 A0A087X0H9 RBM26 RNA-binding protein 26 1 RLNHS(0.993)PPQS(0.002)S(0.003)S(0.002)R;RLNHS(0.442)PPQS(0.276)S(0.163)S(0.118)R;RLNHS(0.898)PPQS(0.011)S(0.057)S(0.035)R 120.29 0.0020888 153557100.0 24304.800000000003 26156.5 28684.7 34109.2 35563.5 23461.2 17944.7 22756.9 16993.1 34052.5 True False 22954.036515823256 28162.619443596537 26839.15763153993 29463.468118348042 31095.695188276102 26692.767340431077 18779.16410674849 22823.11881139241 20392.19482688491 33069.315845979596 0.6941188811625776 0.8516238913064906 0.8116030508929595 0.8909609214649074 0.9403186728477954 0.8071762798103442 0.5678727734862277 0.6901599935629492 0.6166500366037687 1.0 15.013205578213572 -7.020929290933078 23.998879406406836 0.6920897839159761 0.8433779549736125 0.16097709030157592 0.12286211743568926 636.5067443331055 729857.8229712503 0.04437713493736406 0.03480375023671833 9.529513048677463e-08 7.020929290933078 0.15128817105763637 RLPATLLNAFPTAPS(ph)PRPPR ddPTM_A459_Selumetinib_30min_R1 2 RLPATLLNAFPTAPSPRPPR 20 2 Q93015;Q93015-2 Q93015 NAT6 N-acetyltransferase 6 1 RLPATLLNAFPT(0.009)APS(0.991)PRPPR;RLPATLLNAFPT(0.006)APS(0.994)PRPPR 88.385 0.00077812 15171400.0 3665.0 4050.7 4095.1 5033.7 3419.3 3956.8999999999996 3374.2 3612.3 2842.71 3364.6 True False 3750.387369151418 3576.442160880658 3539.0079127741437 4154.658789251597 3110.0249187264467 3917.0971785777447 3119.6813774159955 3516.4900695959373 4823.871246676292 3796.4791839793456 0.9878593263404607 0.942041820214051 0.932181566465135 1.0943452045736806 0.8191866115980175 1.031771014340706 0.8217301415955737 0.92625032278198 1.270617067263903 1.0 11.890446382585008 -8.236085386039782 24.579578470524613 1.135308562697804 0.9435784634338221 0.3686444015304622 0.0999194706047987 522.650749679968 506688.67880583747 0.0629618517083744 0.02377713438531584 5.806502454532459e-09 8.236085386039782 -0.19173009926398177 RLPDAHSDYAR ddPTM_A459_Selumetinib_30min_R1 3 RLPDAHSDYAR 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 ;; 129.0 0.0036106 21416900.0 4247.0599999999995 5034.15 5565.2 5880.7 6152.5 5025.15 5170.99 4627.72 2415.86 4006.84 False True 4346.008234659812 4444.749377687157 4809.476407455413 4853.746139410743 5596.007461312099 4974.6015534711405 4780.938061112067 4504.97783264693 4099.5379725668045 4521.156943926708 0.9612602014397722 0.9830999969283992 1.0637711689960259 1.0735628511925037 1.2377379353816158 1.1002939325416579 1.0574589912288546 0.9964214665669788 0.9067453360745934 1.0 12.142476283782106 -7.855673359721622 3.082874567644526 0.9527136470729458 1.0735632525271943 0.2943661658972425 0.07293525569826577 0.34487304081112397 6.426222882683395 0.05225506822496092 0.02231587207440801 1.3942050140495922e-08 7.855673359721622 0.1208496054542485 RLPDAHSDYAR ddPTM_A459_Selumetinib_30min_R2 1 RLPDAHSDYAR 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 69.65 0.046229 11627000.0 1849.9 1789.6 3904.9 5526.5 5900.0 2961.7 2948.2 5467.2 1051.5 3382.2 False True 1747.089963736439 1926.8565655290408 3653.6629853336544 4773.781166255745 5158.789253330776 3369.647291364239 3085.29714174747 5483.108646856316 1261.829381364759 3284.5470979890515 0.531911984092445 0.5866430007073882 1.1123795385886208 1.4534062151760498 1.570624228980982 1.0259092626278035 0.9393371596456719 1.669365207219383 0.38417149875467094 1.0 11.681478737544138 -5.273319377241056 4.33941447089216 1.1870630948230507 0.544842851705684 0.3067322500261631 0.34910222488883674 0.21149767277473086 10.223264422260378 0.08920684817622394 0.2216458301132814 5.329428287718136e-06 5.273319377241056 -0.6422202431173667 RLPENLYNDR ddPTM_A459_Selumetinib_30min_R1 1 RLPENLYNDR 10 1 E5RHG9;B7Z2R2;P14927;P14927-2 E5RHG9 UQCRB Cytochrome b-c1 complex subunit 7 0 92.866 0.040257 0.0 711.27 1408.8 1385.0 1363.6 636.98 1032.8 508.77 981.39 1419.6 868.46 False True 727.8412071095034 1243.857041066649 1196.924607260431 1125.4728579421653 579.3652714679529 1022.410969707371 470.3930692869228 955.3603491960123 2408.9575165182728 979.9353005167632 0.7427441451753811 1.2693256793695544 1.2214322788751868 1.1485175167673354 0.59122808532607 1.043345381239158 0.4800246190119529 0.9749218634048682 2.458282210313194 1.0 9.936542689303641 -8.10601532921694 12.255964527726526 1.728220788828193 0.9364210755857579 0.37665430399568034 0.4094808808881677 0.717626316143732 79.95887058521164 0.26282074226693697 0.09929163147038579 7.834019906741238e-09 8.10601532921694 -0.7917997132424351 RLPSS(ph)PASPSPK ddPTM_A459_Selumetinib_30min_R1 2 RLPSSPASPSPK 12 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 RLPS(0.206)S(0.794)PASPSPK;RLPS(0.028)S(0.972)PASPSPK 173.59 0.00031863 90254000.0 11076.3 11964.400000000001 12953.1 12973.1 12990.3 9458.1 11190.7 11715.8 5631.1 9529.5 True False 11334.356239271987 10563.602485901347 11194.140166285266 10707.591620247507 11815.329658623737 9362.960101267701 10346.576489315748 11405.058925718264 9555.565420728411 10752.704150190562 1.0540935639032825 0.9824135713539682 1.0410534884926486 0.9958045409496126 1.0988240254349733 0.8707539955055649 0.9622301836633702 1.0606689039720432 0.8886662635983587 1.0 13.392411902012814 -6.7506522620550555 24.999957458448808 0.9606160584119556 1.0297688220449424 0.30807379124460144 0.05805171150246794 303.5863014261491 703583.2406692294 0.018839397319985678 0.018657959845026006 1.7756106365613676e-07 6.7506522620550555 0.06915276363298672 RLPSS(ph)PASPSPK ddPTM_A459_Selumetinib_30min_R2 1 RLPSSPASPSPK 12 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 RLPS(0.062)S(0.937)PASPSPK 207.64 1.6217e-05 17122000.0 94930.0 61980.0 70048.0 82106.0 66814.0 43586.0 64888.0 50101.0 45217.0 46477.0 True False 89654.17063489935 66733.66670288895 65541.1879424959 70923.02115924993 58420.22799526138 49589.57586568585 67905.42057313271 50246.78561533292 54261.66346854047 45135.08824825176 1.986351951762761 1.4785318760393422 1.4521116604892101 1.5713500053253362 1.294341725310002 1.0986923431484954 1.5044929168995902 1.1132532928475918 1.2022057688264787 1.0 15.461961807706023 -1.5228787452803376 0.2713907559047848 1.1007518642314058 6.560273186452998 0.7187296158043581 0.14691221451762707 29.057957237853174 0.40637910648545716 0.16926521428963892 74.43370774664108 0.029999999999999995 1.5228787452803376 5.459521322221592 RLPSSPASPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 RLPSSPASPSPK 12 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 RLPSSPAS(0.355)PS(0.645)PK;RLPSSPAS(0.005)PS(0.994)PK 173.33 0.00033786 257750000.0 5392.8 6442.4 6979.6 7202.700000000001 6189.9 6081.7 6256.9 6664.3 3858.0 6697.5 True False 5518.441747437861 5688.1208130094965 6031.808656198486 5944.8836564241965 5630.024637915608 6020.523619741781 5784.93699554091 6487.5411153027735 6546.744222828614 7557.189364174535 0.7302240927822291 0.7526767610157411 0.7981550237172513 0.7866527315838342 0.74498922371923 0.796661738857909 0.7654878972551449 0.8584595148637515 0.8662935262498492 1.0 12.88363405822061 -8.537159116892157 0.7393236331311804 1.000717093638783 0.7626872776725726 0.9008017073519426 0.024056340157436757 0.2135036493941609 0.2635549859302581 0.023694328264473274 0.009075046915172922 2.902958872996311e-09 8.537159116892157 -0.23802981596621042 RLPSSPASPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 RLPSSPASPSPK 12 1 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 RLPSSPAS(0.008)PS(0.992)PK;RLPSSPAS(0.025)PS(0.975)PK;RLPSSPAS(0.01)PS(0.99)PK 153.0 0.0008632 152774000.0 178894.0 126636.0 162761.0 144016.0 124497.0 99809.0 144022.0 136061.0 85640.0 102576.0 True False 168951.78764942256 136348.57400108152 152289.1344607776 124400.77235854295 108856.57384269871 113556.7837741071 150719.30837417906 136456.91498388894 102770.39298152918 99614.36435554508 1.6960584825537541 1.3687641825874042 1.5287868917902736 1.2488236326493019 1.092779887187416 1.139963945047107 1.5130278584746015 1.369851786604238 1.0316824651384569 1.0 16.6040661729501 -1.5228787452811086 0.45838764323840886 1.2009791728545833 12.468308228249157 0.47337920747168083 0.16183766052617804 93.04725421134575 1.0995503978706598 0.1041205295201838 986.4069774469215 0.029999999999946743 1.5228787452811086 11.267329055394573 RLQSIGTENTEENR ddPTM_A459_Selumetinib_30min_R1 2 RLQSIGTENTEENR 14 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 203.32 4.9782e-05 19037300.0 2398.67 3665.3999999999996 2778.3 1924.17 3052.2 2580.1 2923.5 2960.8 1579.38 2771.1 False True 2454.5543440006627 3236.2532640017685 2401.0221201095 1588.1498306443068 2776.129048909678 2554.146536543364 2702.978041276648 2882.2699659661857 2680.092506648795 3126.797677799787 0.7850058100746201 1.0350056503428777 0.7678853470938393 0.5079157637605225 0.8878505534976406 0.8168569890779194 0.8644556891121381 0.9217961195347739 0.8571365284288806 1.0 11.610470156090637 -8.1164787662728 0.746011153636595 0.9822203428093487 0.7972738940132925 0.18644499732327724 0.12509386269766495 1.1968633924197736 1.4057240582121462 0.12728642284171765 0.05331599848507879 7.647530781869171e-09 8.1164787662728 -0.18494644879605615 RLQSIGTENTEENR ddPTM_A459_Selumetinib_30min_R2 3 RLQSIGTENTEENR 14 1 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ;; 204.18 3.6175e-05 23069200.0 38793.9 33275.4 40477.2 45457.6 46557.4 38114.2 42637.8 38814.1 37338.4 36899.0 False True 36637.89034228611 35827.516182725216 37872.941020243146 39266.19646126612 40708.44318356311 43364.085083740705 44620.54218519787 38927.04260497984 44807.123322063664 35833.62999488441 1.02244428899658 0.9998293833987775 1.05691053420069 1.0957917594972024 1.1360401720220539 1.2101504952172397 1.2452141240384487 1.0863270790745188 1.2504209963785502 1.0 15.129026577447886 -5.91847680430505 1.5228988840356932 1.1681854695556764 1.012103646504001 0.3979595762954439 0.07119500094492366 0.3580094700677113 1.6873485886059305 0.02293319619984726 0.0433169944591754 1.2064885251024164e-06 5.91847680430505 -0.1560818230516754 RLQSIGTENTEENRR ddPTM_A459_Selumetinib_30min_R1 2 RLQSIGTENTEENRR 15 2 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 ; 115.06 0.0015332 25156000.0 1644.92 1353.48 4483.8 4718.0 2800.3 2375.7 1814.82 1821.8899999999999 1376.19 1129.04 False True 1683.2434355428518 1195.013932384219 3874.924587750413 3894.089867828642 2547.0133594331205 2351.802614963012 1677.9266662800358 1773.567558867242 2335.293917059231 1273.963281780906 1.3212652669155445 0.9380285519011806 3.041629726041677 3.056673550579098 1.9992831786113843 1.8460521182960363 1.3170918583575022 1.3921653663266702 1.8330935831954773 1.0 10.315107981443123 -7.03340115850993 2.9242525685971206 1.4201083714643532 2.1134998669394176 0.19983690707558666 0.6431223439232364 0.5120310612782397 8.785523505255224 0.2918497319878191 0.2304892404376217 9.259741044593445e-08 7.03340115850993 0.6933914954750644 RLQSIGTENTEENRR ddPTM_A459_Selumetinib_30min_R2 1 RLQSIGTENTEENRR 15 2 P04075;P04075-2;H3BQN4;J3KPS3;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 70.628 0.032458999999999995 4571200.0 8923.2 12311.0 10641.0 14392.0 11951.0 6938.3 5156.7 4750.2 5630.3 10902.0 False True 8427.284266399807 13255.214113895858 9956.369645044793 12431.784772415218 10449.608536704429 7893.987845383566 5396.496767807202 4764.022295562055 6756.517323726111 10587.230933202252 0.7959856849793736 1.2520000930863455 0.9404130039159686 1.1742243888747457 0.9870010961916179 0.7456140227023387 0.5097174891012751 0.44997812228897055 0.6381760600439184 1.0 13.370037684524405 -6.83512362654004 2.9481764542654503 0.6054524476641955 1.051414851202118 0.49991312421270584 0.180384408436136 0.1829810580550403 3.220983588709999 0.06428306834967148 0.057262050585767756 1.4617610094194174e-07 6.83512362654004 0.4459624035379225 RLRAAT(ph)RVPDT(ph)T(ph)LVK ddPTM_A459_Selumetinib_30min_R2 1 RLRAATRVPDTTLVK 15 3 Q9H611-2;Q9H611-4;Q9H611;Q9H611-3 Q9H611-2 PIF1 ATP-dependent DNA helicase PIF1 3 RLRAAT(1)RVPDT(1)T(1)LVK 54.355 0.04634 801890.0 21936.0 20859.0 23304.0 24866.0 21537.0 16704.0 16996.0 18860.0 17193.0 20237.0 True False 20716.884936765528 22458.818227743777 21804.646011476725 21479.207903757404 18831.329516777114 19004.82437618539 17786.3476769351 18914.87947755893 20632.080412557585 19652.70522795945 1.0541492734187095 1.1427850755015718 1.1094984511575414 1.0929389951465527 0.9582054632349656 0.9670335028048792 0.9050330461188048 0.9624567843540017 1.0498341156211308 1.0 14.262440295103787 -6.233781400158608 5.891156551837605 0.9679517395389104 1.1045355544857172 0.7039509496705261 0.0399237606602532 0.09958085971195092 11.554997024065878 0.012248812138806502 0.015486911402689263 5.837388522178347e-07 6.233781400158608 0.13658381494680671 RLS(ph)APLPSSCGDPEK ddPTM_A459_Selumetinib_30min_R2 1 RLSAPLPSSCGDPEK 15 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 RLS(0.964)APLPS(0.015)S(0.021)CGDPEK 62.739 0.038448 15438000.0 95745.0 90581.0 103490.0 119280.0 108310.0 75590.0 92168.0 95155.0 74046.0 105820.0 True False 90423.87619760285 97528.27143617894 96831.5660713925 103033.85823052323 94703.12949631459 86001.83636229954 96453.99462742728 95431.88529624167 88857.26901810273 102764.70164662089 0.8799118252544079 0.9490444663728157 0.9422648489202958 1.0026191540440403 0.9215531011997895 0.8368810981229318 0.9385907133667905 0.9286446004037969 0.864667221276602 1.0 16.648985276863833 -6.513414885309901 24.9873632035594 0.9073344707697316 0.946062654457552 0.06705049815933894 0.04939638742802138 1013.7832060138809 2676693.6870738245 0.015521291499089802 0.01638352605210916 3.0660915248650127e-07 6.513414885309901 0.03872818368782038 RLS(ph)AQFENLMAESR ddPTM_A459_Selumetinib_30min_R1 4 RLSAQFENLMAESR 14 1 Q9H7C4-2;Q9H7C4 Q9H7C4-2 SYNC Syncoilin 1 RLS(1)AQFENLMAESR;RLS(1)AQFENLMAESR;RLS(1)AQFENLMAESR;RLS(1)AQFENLMAESR 111.73 0.0019712 31740700.0 6538.009999999999 6082.74 10196.7 9624.640000000001 8392.72 7219.87 6977.679999999999 6960.7 5000.299999999999 5276.549999999999 True False 6690.3329122471105 5370.5699730108945 8812.044146463859 7943.877300868647 7633.599957855067 7147.2446629174565 6451.347979837604 6776.079624459886 8485.143892537564 5953.846590449447 1.1236992439440847 0.9020336502498763 1.4800589858326616 1.3342428596684712 1.2821290978676054 1.2004415220207953 1.083559658756777 1.1381011454560117 1.4251532624553287 1.0 12.539606333572745 -10.042485993527965 15.09372444353296 0.9999632207495937 1.2155536823119717 0.14061490246756037 0.16210989827212946 0.0 0.0 0.16282637816364953 0.03949119740032307 9.068052095721046e-11 10.042485993527965 0.21559046156237804 RLS(ph)AQFENLMAESR ddPTM_A459_Selumetinib_30min_R2 2 RLSAQFENLMAESR 14 1 Q9H7C4-2;Q9H7C4 Q9H7C4-2 SYNC Syncoilin 1 RLS(1)AQFENLMAESR;RLS(1)AQFENLMAESR 140.75 0.00028746 9835700.0 14821.2 13893.2 14593.8 16621.5 17952.699999999997 14746.0 13698.6 12580.0 13348.1 12913.2 True False 13997.497037964491 14958.763766321012 13654.850796528022 14357.6230263132 15697.321326825662 16777.1276491397 14335.612043260937 12616.60571726889 16018.092977075545 12540.3623634771 1.1161955797012049 1.1928494036095267 1.0888721075793464 1.144912930756191 1.2517438389613826 1.3378503078987474 1.143157719669439 1.0060798365774377 1.2773229762265152 1.0 13.614291416081608 -11.1025721302484 5.690082733161345 0.9993025154971904 1.1718358896468413 0.24203241456466773 0.09193277225174844 0.0008483155523943579 6.266216049263611e-05 0.09282998282220893 0.022425432265297786 7.896376907154565e-12 11.1025721302484 0.17253337414965086 RLS(ph)ASSTGSTR ddPTM_A459_Selumetinib_30min_R1 2 RLSASSTGSTR 11 1 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 RLS(0.948)AS(0.024)S(0.024)T(0.003)GSTR;RLS(0.894)AS(0.063)S(0.04)T(0.002)GSTR 133.98 0.0030845 29339000.0 7003.2 7103.5 7825.9 8339.9 7245.9 6541.5 6233.2 6462.4 4004.5 4588.4 True False 7166.360934144944 6271.81891767244 6763.185764591628 6883.493024312021 6590.50962436755 6475.698449206781 5763.024705621886 6290.996159166399 6795.344022891958 5177.365834800815 1.3841712490113518 1.2113918772196888 1.3062986044237732 1.3295357608386669 1.2729464817934972 1.2507708853948345 1.1131190820792372 1.2150959310002918 1.3125099210134126 1.0 12.33800254788809 -6.970821875152035 3.183301759746407 1.1778310765673312 1.2978231162933738 0.36920518073752895 0.08509431279135642 0.3170416723134505 6.639913061240367 0.03216824815548822 0.026657667646393646 1.0694934394676818e-07 6.970821875152035 0.11999203972604255 RLS(ph)DCESTDVK ddPTM_A459_Selumetinib_30min_R1 1 RLSDCESTDVK 11 1 Q7Z333-3;Q7Z333;Q7Z333-4 Q7Z333-3 SETX Probable helicase senataxin 1 RLS(0.999)DCES(0.001)TDVK 110.44 0.0059717 0.0 1480.9 2304.6 1831.0 2612.6 1847.3 2366.5 2580.8 2558.2 1453.6 1624.7 True False 1515.402088670214 2034.776360620526 1582.360256963068 2156.3584545759036 1680.2120411673036 2342.6951586100813 2386.1281781860007 2490.34822579529 2466.6530332565235 1833.2460709181594 0.826622302761158 1.109930845018221 0.8631466784873902 1.176251507521801 0.916522919547723 1.2778945476952641 1.3015864133236281 1.3584364179479893 1.3455111522596253 1.0 10.840184732005593 -6.770985292966101 24.90343813831544 1.2818943549007935 0.9903751002516193 0.5033430858112421 0.13677493215367925 146.11933933056613 381194.68208777433 0.044757295749163734 0.03998106714499259 1.6943951788079495e-07 6.770985292966101 -0.29151925464917416 RLS(ph)DCESTDVK ddPTM_A459_Selumetinib_30min_R2 4 RLSDCESTDVK 11 1 Q7Z333-3;Q7Z333;Q7Z333-4 Q7Z333-3 SETX Probable helicase senataxin 1 RLS(1)DCESTDVK;RLS(0.998)DCES(0.001)T(0.001)DVK;RLS(0.997)DCES(0.001)T(0.001)DVK;RLS(1)DCESTDVK 149.35 0.00032488 15737100.0 80094.0 67845.0 85186.0 80194.0 77354.0 64090.0 78715.0 105270.0 84365.0 118999.0 True False 75642.69612168573 73048.49334394165 79705.22550350406 69271.4388576339 67636.09896646591 72917.81574890565 82375.40347081349 105576.31827161335 101240.3573550529 115563.18967346655 0.6545570119293219 0.6321086632373706 0.6897111937522479 0.5994247740423757 0.5852737290964135 0.6309778741391704 0.7128169766131592 0.9135808605657914 0.8760606006213223 1.0 16.818322404000483 -7.682712730817482 2.3740048857685587 0.9352159165400475 0.6308874360474558 0.9213503227077524 0.03895330272012872 0.07848197824422067 0.885638981330574 0.02482948351954644 0.01154802060224733 2.0762864473752497e-08 7.682712730817482 -0.30432848049259176 RLS(ph)DEHEPEQR ddPTM_A459_Selumetinib_30min_R1 2 RLSDEHEPEQR 11 1 Q9UK59-2;Q9UK59 Q9UK59-2 DBR1 Lariat debranching enzyme 1 RLS(1)DEHEPEQR;RLS(1)DEHEPEQR 110.55 0.0044963 51849000.0 3683.6 3962.3 4616.5 5433.4 4906.9 3931.2000000000003 3887.3 4044.6 2832.44 3176.2 True False 3769.4207129621186 3498.3920739767027 3989.6046566193377 4484.558687549838 4463.071761383555 3891.6556972440126 3594.0778313168157 3937.3240692876348 4806.443806767415 3583.89620880794 1.0517661487233434 0.9761421286082173 1.1132031800514508 1.2513081926112677 1.2453127828911212 1.0858728798227217 1.002840936767045 1.0986155401518312 1.3411224898072907 1.0 11.807313141587095 -5.407639383111774 5.2570850435813306 1.1485670004098243 1.0159818646090175 0.19798044913584356 0.10477282367717272 0.35743209824024824 13.942916639707262 0.028738002834616222 0.06128762658236449 3.911655657252161e-06 5.407639383111774 -0.13258513580080677 RLS(ph)DEHEPEQR ddPTM_A459_Selumetinib_30min_R2 2 RLSDEHEPEQR 11 1 Q9UK59-2;Q9UK59 Q9UK59-2 DBR1 Lariat debranching enzyme 1 RLS(1)DEHEPEQR;RLS(1)DEHEPEQR 117.48 0.0028681 43793000.0 40523.4 38878.8 40980.5 45193.0 52382.0 33861.1 32408.7 41811.1 31998.4 39724.7 True False 38271.271656023164 41860.67894495447 38343.85924619478 39037.635437726596 45801.3048589784 38525.159164538476 33915.76876662074 41932.7633787998 38398.97410999723 38577.744693834116 0.9920557036124525 1.0850991751118375 0.9939372959851456 1.0119211412575393 1.1872468238481246 0.9986368946730044 0.8791537461763933 1.0869677248266385 0.9953659659149162 1.0 15.235481183534503 -6.969094421612819 24.99996153686567 0.9892298400272921 1.0543810755537029 0.16267252578764135 0.07054129723803604 375.85609203922473 304034.26615808957 0.025087381098927063 0.022124741305745616 1.0737559376051878e-07 6.969094421612819 0.06515123552641078 RLS(ph)DPLLPSPEDETGSLVHLEDPER ddPTM_A459_Selumetinib_30min_R2 1 RLSDPLLPSPEDETGSLVHLEDPER 25 1 Q8WYL5-4;Q8WYL5;Q8WYL5-2;Q8WYL5-5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 RLS(1)DPLLPSPEDETGSLVHLEDPER 90.1 3.5271e-05 2083800.0 5692.0 4851.7 7118.3 7298.2 8198.1 4707.9 8558.0 6439.6 5609.5 6866.3 True False 5375.661426881353 5223.809789325686 6660.316327819035 6304.172569902774 7168.181386056105 5356.370490938887 8955.963957355289 6458.338169866832 6731.556742525553 6668.052078210107 0.8061816800213613 0.7834086668873025 0.9988398785281911 0.9454294141618329 1.0750038095053762 0.8032886408374735 1.3431154784500907 0.9685494495418566 1.009523720506468 1.0 12.703049656635196 -5.176955413292548 0.8264461987401601 1.0436496898158274 0.7006301569186041 0.311321482748966 0.12948974887311823 1.809334408768928 1.4052900894440978 0.05033221439627316 0.5099914930889502 6.653414597688294e-06 5.176955413292548 -0.3430195328972233 RLS(ph)DSPVFDAPPSPPDSLSDR ddPTM_A459_Selumetinib_30min_R1 1 RLSDSPVFDAPPSPPDSLSDR 21 1 P47974 P47974 ZFP36L2 Zinc finger protein 36, C3H1 type-like 2 1 RLS(0.62)DS(0.38)PVFDAPPSPPDSLSDR 82.486 0.00079927 5171500.0 757.2 1050.3 866.77 777.27 1064.0 708.61 762.79 852.37 379.41 668.71 True False 774.8412867452811 927.3303877287765 749.067394826804 641.5343856649358 967.7613878644569 701.4820267664016 705.2521361742474 829.7623787120368 643.8310589899957 754.5454422869963 1.0268981075503802 1.2289921000888644 0.992739936983002 0.850226308067638 1.2825753541512515 0.9296749903362194 0.9346715209579123 1.0996850980864201 0.8532700920418658 1.0 9.559463979046113 -4.989359076686816 0.351819572554932 0.9671619042811589 1.1988396506497434 0.08621922614841815 0.13253368386114922 14.78630126617225 1.6397553685450157 0.1293759494471156 1.4452531558974562 1.0248042629680555e-05 4.989359076686816 0.23167774636858451 RLS(ph)EGVEPWR ddPTM_A459_Selumetinib_30min_R2 1 RLSEGVEPWR 10 1 A0A3F2YNX6;Q92794;A0A3B3ITI3;A0A3B3IS53 A0A3F2YNX6 KAT6A Histone acetyltransferase KAT6A 1 RLS(1)EGVEPWR 93.766 0.022394 0.0 6028.1 3033.4 4607.2 4802.6 5009.6 4112.0 4637.8 4762.1 4684.8 5781.5 True False 5693.082334396257 3266.05202608169 4310.777767940082 4148.477595052899 4380.249261607771 4678.390674980504 4853.466889626356 4775.956922591905 5621.890904248812 5614.573072859002 1.0139831222282545 0.581709772710925 0.7677837142735746 0.7388767660905068 0.7801571383551874 0.8332584889839568 0.8644409515459235 0.8506358115951878 1.001303363816776 1.0 12.454960610211247 -7.845557555638472 0.8134729779506226 1.009084846666905 0.7623933015593058 0.386885365941823 0.10157433200484528 0.5927745562890144 0.7425968687290511 0.08880713278226543 0.0383990091799418 1.42706069390918e-08 7.845557555638472 -0.24669154510759905 RLS(ph)EQLAHTPTAFK ddPTM_A459_Selumetinib_30min_R2 2 RLSEQLAHTPTAFK 14 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8;F8W860;Q9UBF8-3 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 RLS(1)EQLAHTPTAFK;RLS(0.994)EQLAHT(0.005)PT(0.001)AFK 82.865 0.014871 12958600.0 139038.0 86132.0 96777.0 122981.0 105843.0 82758.0 93682.0 94724.0 82869.0 82497.0 True False 131310.82457321323 92738.04744196884 90550.4731828308 106230.77564594192 92546.05609157444 94157.16329767428 98038.39862736137 94999.63115759751 99445.11555332033 80115.09725705229 1.6390272129595942 1.1575601929860404 1.1302547994455554 1.3259769916411197 1.1551637489078614 1.1752736565440032 1.2237193985148829 1.1857893756627125 1.2412780981123566 1.0 16.28978651588531 -4.759180169293603 24.996987118929813 1.1869133147440656 1.6390277981983228 0.7496907222530951 0.07987622250741357 28.181837476279224 311745.99959614646 0.018501516807805037 0.11969155467565452 1.7410844257412198e-05 4.759180169293603 0.4521144834542572 RLS(ph)ESQLSFR ddPTM_A459_Selumetinib_30min_R2 3 RLSESQLSFR 10 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 RLS(1)ESQLSFR;RLS(0.975)ES(0.025)QLSFR;RLS(0.972)ES(0.028)QLSFR 126.34 0.005118800000000001 56380800.0 80128.4 92108.5 96125.0 95845.0 100230.0 81991.0 80174.2 80327.0 77718.0 89953.7 True False 75675.1843073999 99172.9257744926 89940.4221529868 82790.74565815303 87638.21133243116 93284.51600980705 83902.45916216349 80560.73827114925 93263.7716223551 87356.50295321898 0.8662799190568029 1.1352666650083456 1.029579013724388 0.9477342024839182 1.0032248129181984 1.0678600087707566 0.960460370158073 0.9222065392692175 1.067622540617263 1.0 16.414627483139732 RLS(ph)ESSALK ddPTM_A459_Selumetinib_30min_R1 3 RLSESSALK 9 1 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 RLS(0.962)ES(0.03)S(0.009)ALK;RLS(0.661)ES(0.2)S(0.139)ALK;RLS(0.992)ES(0.007)S(0.001)ALK 168.85 0.0013332 50497000.0 8557.2 9989.0 6779.099999999999 7097.6 8425.5 8054.9 10545.0 11359.5 6621.1 9149.6 True False 8756.56611058732 8819.483236239892 5858.535454930822 5858.137398452856 7663.415012642846 7973.87501926404 9749.582160171796 11058.20915914377 11235.523113989248 10324.040284651188 0.848172408200088 0.854266643007183 0.5674653811299769 0.5674268248606298 0.742288367862734 0.7723599288079926 0.9443572372210285 1.071112554218146 1.0882874150242485 1.0 13.333720055535379 -7.333894089289411 1.9669370682498994 1.0616639116026028 0.7081117994201763 0.7235119937101953 0.09320599131748597 0.19765604201558817 1.4912343446931633 0.05580668844496056 0.033371792100848355 4.6355995358806244e-08 7.333894089289411 -0.35355211218242644 RLS(ph)ESSALK ddPTM_A459_Selumetinib_30min_R2 1 RLSESSALK 9 1 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 RLS(0.693)ES(0.305)S(0.002)ALK 101.35 0.0087801 20073000.0 51064.0 38203.0 47528.0 56292.0 57851.0 51687.0 59117.0 64431.0 71926.0 63339.0 True False 48226.06730538815 41133.04725799393 44470.10022457372 48624.93249088363 50583.24018549811 58806.41508212968 61866.05763811321 64618.48354287375 86313.20978035365 61510.2384955143 0.784033170492504 0.6687187086909703 0.7229707006877684 0.7905177037222779 0.8223548050327742 0.9560427096444798 1.0057847140785328 1.0505321573023347 1.4032332159896945 1.0 15.90853894930708 -7.095407936727326 0.9344944169347185 1.179117957815461 0.7235145253971089 0.7390573560903584 0.10373145530331722 0.27491409472211786 0.4862790375935346 0.07072189760635866 0.046962376258121274 8.027717172106066e-08 7.095407936727326 -0.455603432418352 RLS(ph)GNEYVLSTK ddPTM_A459_Selumetinib_30min_R2 2 RLSGNEYVLSTK 12 1 O60658-6;O60658-2;O60658 O60658-6 PDE8A High affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A 1 RLS(0.999)GNEY(0.001)VLSTK;RLS(1)GNEYVLSTK 89.506 0.036731 10936200.0 138107.0 91861.0 111885.0 119430.0 103290.0 82135.0 154973.0 130749.0 91836.0 91655.0 True False 130431.56582612492 98906.44332033013 104686.44091117747 103163.42797175833 90313.78677568404 93448.3507027052 162179.55157317364 131129.45794333774 110205.76611223411 89008.68200171083 1.465380262833438 1.111199953712707 1.1761374121814916 1.1590265764161685 1.0146626682321633 1.0498790522581722 1.8220644090658078 1.4732209824297513 1.238146253082546 1.0 16.44165844450398 RLS(ph)IIGPTSR ddPTM_A459_Selumetinib_30min_R1 2 RLSIIGPTSR 10 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 RLS(1)IIGPTSR;RLS(1)IIGPTSR 76.868 0.028963 56017000.0 4179.7 4274.7 4137.7 4617.2 4072.8 3304.3999999999996 3799.2000000000003 3393.0 2023.8999999999999 2993.5 True False 4277.078877719559 3774.216136745884 3575.8230667591965 3810.8926955782954 3704.415959111242 3271.1607361551464 3512.6232852465314 3303.0066179827277 3434.410480192541 3377.744884159235 1.266252788296112 1.1173775007242253 1.0586421382884474 1.1282357982245532 1.0967127732126873 0.9684451752102591 1.0399314944476246 0.9778733241438657 1.0167761621959825 1.0 11.72184465239367 -1.5228787464667757 0.36533100206508756 0.9966926916991005 4.169512023887143 0.7723405284499372 0.04058267241362913 31.992709570576874 0.4442173299652483 0.03411782704194342 70.9325667250909 0.02999999991804376 1.5228787464667757 3.1728193321880425 RLS(ph)IIGPTSR ddPTM_A459_Selumetinib_30min_R2 3 RLSIIGPTSR 10 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 RLS(1)IIGPTSR;RLS(1)IIGPTSR;RLS(1)IIGPTSR 104.9 0.0065899 45303100.0 94821.0 79633.0 102198.0 106830.0 96895.0 75176.0 82880.0 82963.0 72436.0 72236.0 True False 89551.22841853765 85740.59503954745 95622.69194476922 92279.56970797092 84722.18384770933 85530.81162021743 86734.08422360441 83204.40859473594 86925.22403094421 70150.35898833207 1.2765612280534797 1.2222402889457553 1.363110514668555 1.3154539910953207 1.2077227411167055 1.219249806468468 1.2364025711975426 1.1860867113819777 1.239127287223181 1.0 16.098162866279317 -14.522878745277973 0.16371670804639532 0.024123472461862694 1.3171211825919409 0.7612648054983225 0.04443289356205715 66.21542167360832 0.6128788816540612 20.859041265908168 0.18734070630162025 3.0000000000163332e-15 14.522878745277973 1.2929977101300782 RLS(ph)ITSLTGK ddPTM_A459_Selumetinib_30min_R1 1 RLSITSLTGK 10 1 G3V1S3;Q6ZUT9;Q6ZUT9-2 G3V1S3 DENND5B DENN domain-containing protein 5B 1 RLS(0.995)IT(0.004)SLTGK 82.515 0.021783 20953000.0 5478.2 5724.8 6484.4 6974.4 5770.5 5475.6 6137.7 5781.0 2879.4 4315.6 True False 5605.83140127839 5054.5377546126865 5603.854096259595 5756.4519657024375 5248.559293864521 5420.520435447013 5674.728347509382 5627.6691006655365 4886.131496944716 4869.549297503793 1.151201283484701 1.0379888252088794 1.1507952284479834 1.1821323933722745 1.0778326644223553 1.1131462285895035 1.1653498097695276 1.1556858256985645 1.0034052842322436 1.0 12.249572534106008 -8.269973577202025 24.488046500519005 1.001702598056751 1.1276547310222296 0.6047507876667146 0.04123458347350152 360.23743723615524 1033649.0998106193 0.03824567087084961 0.010537406653517595 5.370644707764981e-09 8.269973577202025 0.12595213296547847 RLS(ph)ITSLTGK ddPTM_A459_Selumetinib_30min_R2 1 RLSITSLTGK 10 1 G3V1S3;Q6ZUT9;Q6ZUT9-2 G3V1S3 DENND5B DENN domain-containing protein 5B 1 RLS(1)ITSLTGK 119.21 0.0098232 16818000.0 81195.0 67844.0 81107.0 87577.0 86182.0 63608.0 59547.0 74821.0 49606.0 68927.0 True False 76682.50694933787 73047.41664715699 75888.66392262444 75648.86152124825 75355.04668314462 72369.42462406609 62316.053490142 75038.71672271674 59528.58610744672 66936.89841614671 1.1455939663144041 1.0912877407767116 1.1337343934107107 1.1301518790270095 1.1257624489061666 1.0811589173753668 0.9309671491308589 1.1210366553914857 0.889323938156762 1.0 16.030514083497245 -7.052594302108789 5.172629822374575 0.9955700167857351 1.1227000510606628 0.5676312405079312 0.05743695457338938 0.1591750015231323 9.383072038521034 0.020464155315221444 0.016094312367424955 8.859428303598622e-08 7.052594302108789 0.12713003427492775 RLS(ph)LESEGAGEGAAASPELSALEEAFR ddPTM_A459_Selumetinib_30min_R1 1 RLSLESEGAGEGAAASPELSALEEAFR 27 1 O94811 O94811 TPPP Tubulin polymerization-promoting protein 1 RLS(0.766)LES(0.234)EGAGEGAAASPELSALEEAFR 147.26 5.1906e-14 23010000.0 523.15 732.53 672.04 543.94 657.96 561.22 599.77 658.74 366.16 617.24 True False 535.3383771273027 646.765047056042 580.78065925148 448.9510900183788 598.4476341722731 555.5746363469889 554.5288660224027 641.2680753109173 621.3467767317068 696.4687664267398 0.7686466399259757 0.9286346757145987 0.8338933305382779 0.6446105147280903 0.8592598304768669 0.7977021556865878 0.7962006234212551 0.9207420436108976 0.8921387529257783 1.0 9.443914845499142 -8.238688653558782 1.0639090169251118 0.9913047869147632 0.8039074859477272 0.4278375691587051 0.0717210495488581 0.48818121615178744 1.1153338821465852 0.06916594336393878 0.02347849210358113 5.771800964849527e-09 8.238688653558782 -0.187397300967036 RLS(ph)LGAQK ddPTM_A459_Selumetinib_30min_R2 2 RLSLGAQK 8 1 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 1 RLS(1)LGAQK;RLS(1)LGAQK 90.149 0.014719 40389000.0 365310.0 272710.0 311860.0 408010.0 220810.0 235107.0 373700.0 340790.0 290450.0 257470.0 True False 345007.5326517967 293625.98009914276 291795.2671274951 352438.3341434913 193069.87373355418 267490.8551611478 391077.79047250166 341781.64247917815 348548.1158510646 250036.1721126011 1.379830485072481 1.174334007828721 1.1670122153209426 1.4095493910568047 0.772167771175953 1.0698086316914424 1.5640848568757642 1.3669287911081138 1.393990769040008 1.0 17.931777295534275 -7.239232660104793 24.92365604373406 1.3618285488846762 1.1564168585625405 0.12760813259380288 0.21034717471613937 1366.4482448825324 1533632.004592267 0.08062499820272112 0.062401836646893784 5.7645756099177513e-08 7.239232660104793 -0.2054116903221357 RLS(ph)LGQGDSTEAATEER ddPTM_A459_Selumetinib_30min_R1 3 RLSLGQGDSTEAATEER 17 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RLS(0.996)LGQGDST(0.003)EAAT(0.001)EER;RLS(1)LGQGDSTEAATEER;RLS(1)LGQGDSTEAATEER 137.09 0.00026303 49981000.0 2745.08 3183.33 2616.95 3050.9599999999996 2924.55 2549.11 3670.26 3051.17 1381.7399999999998 2203.96 True False 2809.0350230041386 2810.6242437100336 2261.58256387739 2518.167109612225 2660.024968871238 2523.4682678066965 3393.4093332567227 2970.2430600030552 2344.7118617032675 2486.8597343883707 1.1295510495267258 1.130190096708969 0.9094129968828393 1.0125891198409525 1.069632087442783 1.0147207873898563 1.3645358788565984 1.1943749858226604 0.9428404140694072 1.0 11.280109422611343 RLS(ph)LGQGDSTEAATEER ddPTM_A459_Selumetinib_30min_R2 2 RLSLGQGDSTEAATEER 17 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RLS(0.999)LGQGDS(0.001)T(0.001)EAATEER;RLS(1)LGQGDSTEAATEER 138.04 0.00026179 36744000.0 31067.0 28662.0 33861.0 40851.0 32589.0 28224.0 30949.0 33892.0 27801.0 36089.0 True False 29340.42051105462 30860.283237144264 31682.420125069235 35287.02332809436 28494.87847064351 32111.59980803739 32388.189824280053 33990.62010887734 33361.976824842306 35047.016799517165 0.8371731231474981 0.8805395167776282 0.9039976299924539 1.0068481300405716 0.8130471883996723 0.9162434563754306 0.9241354266913313 0.9698577286425594 0.9519205875834181 1.0 15.097004026874961 -1.5228787452803376 0.07609563582968458 1.0869446034967911 0.49836074318087786 0.3874016480479471 0.04798674173802151 243.32452768932077 1.3620718443997304 1.6843370217873008 15.150681781484929 0.029999999999999995 1.5228787452803376 -0.5885838603159133 RLS(ph)LPADIR ddPTM_A459_Selumetinib_30min_R1 1 RLSLPADIR 9 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;H0YBX5;E5RIU4;Q00537-2;F5H6Z0;Q00537;F8VQZ9;F8VZY6 E5RJM2;Q00537-2 CDK16;CDK17 Cyclin-dependent kinase 16;Cyclin-dependent kinase 17 1 RLS(1)LPADIR 86.288 0.017478 72649000.0 5067.6 5778.9 5509.7 5754.9 5634.9 5209.5 5456.8 4991.8 3173.5 4337.4 True False 5185.665220166912 5102.303701462278 4761.513002615736 4749.914747852277 5125.224289922395 5157.097159847549 5045.189182705117 4859.401248348423 5385.1977167305895 4894.147539853774 1.0595645468264423 1.0425316482417943 0.9728993586405037 0.9705295374062617 1.0472149129520367 1.0537273586160893 1.0308616856401218 0.992900440531797 1.1003341588863271 1.0 12.256841878479667 RLS(ph)LPADIR ddPTM_A459_Selumetinib_30min_R2 1 RLSLPADIR 9 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;H0YBX5;E5RIU4;Q00537-2;F5H6Z0;Q00537;F8VQZ9;F8VZY6 E5RJM2;Q00537-2 CDK16;CDK17 Cyclin-dependent kinase 16;Cyclin-dependent kinase 17 1 RLS(1)LPADIR 75.89 0.029742 1823500.0 6486.9 6033.2 7349.8 8167.1 8843.1 6777.1 5837.0 6113.2 5617.0 8108.5 True False 6126.3840671181715 6495.927040204412 6876.921869857183 7054.726890966669 7732.150719682946 7710.584008611463 6108.432065796076 6130.988399905263 6740.556952093061 7874.3865365869015 0.7780141397241607 0.8249438873774194 0.8733279523306126 0.8959081267077971 0.9819369018471366 0.9791980585135922 0.7757343429122205 0.7785988624534422 0.8560104232595507 1.0 12.942951817673366 -5.0667591928120785 2.063512957473943 0.8879484307505892 0.7745302792519173 0.20556353456209864 0.07445147319106094 0.8081757351077861 5.628158078206886 0.022569727394410762 0.1379885910980403 8.575131865242736e-06 5.0667591928120785 -0.11341815149867185 RLS(ph)LPGLLSQVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 RLSLPGLLSQVSPR 14 1 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 2 RLS(1)LPGLLS(0.057)QVS(0.943)PR 104.3 0.011255 0.0 1071.3 1216.8 1835.3 1589.7 1086.7 1141.3 1217.6 1143.6 659.65 1154.3 True False 1096.259205613073 1074.3364903250265 1586.0763405812768 1312.0887373648134 988.4081768724678 1129.819558217488 1125.7554517046167 1113.268013063675 1119.377871070216 1302.4656488341418 0.841679937274624 0.8248482340295751 1.2177490761472285 1.0073883626330455 0.7588746603468645 0.8674467224750287 0.8643264048555128 0.8547388670558639 0.8594298606433033 1.0 10.347029608098577 -6.236189136536741 24.637256157888746 0.8600480632479116 0.9798281649716504 0.16712137047296127 0.11419013291422807 1126.898658839783 1099541.1128097314 0.035205994337393104 0.045430277177159036 5.805115479593076e-07 6.236189136536741 0.11978010172373876 RLS(ph)LPSSK ddPTM_A459_Selumetinib_30min_R2 1 RLSLPSSK 8 1 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 RLS(0.969)LPS(0.024)S(0.007)K 65.232 0.043851 19871000.0 176440.0 166980.0 222180.0 235370.0 220700.0 165800.0 179770.0 182620.0 156850.0 192590.0 True False 166634.1711452821 179786.82907467554 207885.1806912933 203312.1999641031 192973.69291696657 188637.44501745317 188129.6612074969 183151.39396563172 188224.38275517087 187029.42629108622 0.8909516242964803 0.9612756272633882 1.1115105511137477 1.0870599562641814 1.031782520770977 1.0085976776930508 1.0058826834805037 0.9792651220593552 1.0063891361256965 1.0 17.51290574895807 -5.00501259669435 5.834532230409329 1.0293787264908065 0.9050861143756209 0.5568380837892164 0.038993669260464416 0.11213329845269467 15.575647325293152 0.011141241409897858 0.03797145665970367 9.885244221291718e-06 5.00501259669435 -0.12429261211518561 RLS(ph)LQPR ddPTM_A459_Selumetinib_30min_R2 2 RLSLQPR 7 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 RLS(1)LQPR;RLS(1)LQPR 79.48899999999998 0.023955 10031100.0 33119.0 24450.0 38388.0 38379.0 36338.0 21600.1 29310.0 30525.0 25476.0 29437.0 True False 31278.378565861494 26325.23638085888 35918.157873694174 33151.71399253222 31772.895574158243 24575.317708814757 30672.97307666319 30613.822696314233 30571.911858914504 28587.077323488786 1.0941439802298845 0.9208789021334669 1.2564473614160532 1.1596748285034675 1.1114426009563352 0.8596652757021181 1.072966387209528 1.070897257172917 1.0694311808432009 1.0 14.803075509261529 -6.616754163385494 19.499373851760726 1.0185432978938047 1.1092891870812174 0.18972789461533612 0.09685690140547544 6.5012292109803225 1339.8183427901993 0.033325242390385715 0.033325147260976934 2.4168285165962855e-07 6.616754163385494 0.09074588918741266 RLS(ph)LTMGGVQAR ddPTM_A459_Selumetinib_30min_R2 1 RLSLTMGGVQAR 12 1 O75815;O75815-3 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 RLS(0.961)LT(0.039)MGGVQAR 73.758 0.027343 12038000.0 8701.0 8972.9 7983.7 11798.0 9914.7 7616.4 8197.3 9142.0 6185.6 12261.0 True False 8217.433252862733 9661.092577579087 7470.037433995319 10191.092047314802 8669.126747457403 8665.489965204639 8578.490692641793 9168.60170646043 7422.892840104472 11906.9930720962 0.6901350494710644 0.8113797093087812 0.6273655648209959 0.8558913224865665 0.7280701932861058 0.7277647608204326 0.7204581913082082 0.7700182280232332 0.6234061609979327 1.0 13.539521508310948 -10.663064162045405 4.718741211392515 1.0000234481750774 0.7324828091640894 0.5810857126206268 0.06913052528701444 1.5743885387335955e-05 2.868663578789475e-06 0.061795921580415726 0.014986399845206165 2.1723802108103586e-11 10.663064162045405 -0.267540639010988 RLS(ph)MEIEK ddPTM_A459_Selumetinib_30min_R1 4 RLSMEIEK 8 1 A0A5K1VW66;P35240-4;P35240-6;P35240-5;P35240-3;P35240;P35240-2;P35240-8 A0A5K1VW66 NF2 Merlin 1 RLS(1)MEIEK;RLS(1)MEIEK;RLS(1)MEIEK;RLS(1)MEIEK 96.756 0.010689 68661000.0 16067.9 18665.9 18475.0 19324.7 19050.6 18212.6 17588.8 17379.5 10388.0 16053.8 True False 16442.25080730916 16480.487750458517 15966.19647591081 15950.003914546023 17327.476593656596 18029.397779717718 16262.062655175883 16918.5392034279 17627.677290498617 18114.461607254223 0.9076864200437842 0.9097972718029138 0.881406073339596 0.8805121709031966 0.9565548769452543 0.9953040929738458 0.8977392211681016 0.9339796881764679 0.973127309698199 1.0 14.14485430661654 -6.269056562576617 24.64419870297318 0.9548569317552119 0.8949577962561271 0.5382536390486599 0.029126285470930977 417.76345973817314 1351605.4528781946 0.009240058260571766 0.010667829133013545 5.38199682746367e-07 6.269056562576617 -0.059899135499084766 RLS(ph)MEIEK ddPTM_A459_Selumetinib_30min_R2 4 RLSMEIEK 8 1 A0A5K1VW66;P35240-4;P35240-6;P35240-5;P35240-3;P35240;P35240-2;P35240-8 A0A5K1VW66 NF2 Merlin 1 RLS(1)MEIEK;RLS(1)MEIEK;RLS(1)MEIEK;RLS(1)MEIEK 92.611 0.012948 58426000.0 200809.0 188192.0 202372.0 207712.0 199603.0 178991.0 201059.0 187972.0 165472.0 199582.0 True False 189648.83968211847 202625.7212673451 189351.60584597324 179421.26727681456 174527.08666653937 203645.38553147748 210408.64189085033 188518.96739956003 198571.02367397925 193819.54908368812 0.9784814822793299 1.0454349018212534 0.976947922648475 0.9257129537503123 0.9004617309845325 1.0506957966533435 1.0855904003780306 0.9726519759787523 1.0245149398641904 1.0 17.564354566055208 -6.795926260537551 24.999991220115213 1.0286626204026739 0.9682894656791522 0.31541351007824525 0.04499535749792209 258.98813719339535 187742.0932894299 0.017435177977281186 0.015377078473143239 1.5998296428491606e-07 6.795926260537551 -0.06037315472352167 RLS(ph)MENEELLWK ddPTM_A459_Selumetinib_30min_R1 2 RLSMENEELLWK 12 1 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 RLS(1)MENEELLWK;RLS(1)MENEELLWK 161.94 0.00024994 35706000.0 8202.900000000001 9822.4 10669.0 11574.0 11051.9 8759.400000000001 10827.4 9772.3 5243.6 9993.2 True False 8394.011609935105 8672.38884169012 9220.208400622047 9552.818170887813 10052.25759637143 8671.288388898856 10010.680500810253 9513.106859095975 8898.006222608637 11275.924562011056 0.7444189222598024 0.7691066744901497 0.8176897911932843 0.8471871302750248 0.8914796778827168 0.7690090813584102 0.8877924329625749 0.8436653514999498 0.7891154444741764 1.0 13.460958110710134 -14.522878745280336 0.14263376686974688 1.5874092262675554 0.7624399084886962 0.589698383654621 0.046510725665837305 104.32807686347131 0.9011714694239927 17.611717026381715 0.28132858625575813 3.0000000000000132e-15 14.522878745280336 -0.8249693177788592 RLS(ph)MENEELLWK ddPTM_A459_Selumetinib_30min_R2 2 RLSMENEELLWK 12 1 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 RLS(1)MENEELLWK;RLS(1)MENEELLWK 151.49 0.00026752 4589600.0 28309.0 34497.0 33444.0 42819.0 43197.0 29775.0 31415.0 33937.0 31421.0 38748.0 True False 26735.699109905854 37142.808974662104 31292.24945107398 36986.97833310497 37770.20667392024 33876.23597946119 32875.85974764155 34035.75105142719 37706.07797609328 37629.244560605446 0.7105032115870806 0.9870729377742385 0.8315938790818631 0.9829317267726158 1.0037460787470172 0.9002635151205419 0.8736784416357836 0.904502640136966 1.0020418537864635 1.0 15.19956670590427 -4.753444408530513 24.997925589883508 0.9360690486979393 0.7105028007755272 0.5798923005201442 0.05907910318766406 220.66308134060475 689894.0132424403 0.01462146719918372 0.15793449030586748 1.7642315788794512e-05 4.753444408530513 -0.2255662479224121 RLS(ph)NPCIQR ddPTM_A459_Selumetinib_30min_R1 1 RLSNPCIQR 9 1 Q5RGS4;Q9HB21-2 Q5RGS4 PLEKHA1 Pleckstrin homology domain-containing family A member 1 1 RLS(1)NPCIQR 66.32600000000001 0.043936 5750500.0 532.5 887.95 852.78 980.37 831.99 1058.8 741.52 756.68 532.05 810.07 True False 544.9062139353698 783.988401203244 736.9771599852346 809.1667833241128 756.7366513997647 1048.1494333134815 685.5865493988233 736.6103883569622 902.8499906054857 914.0503752499991 0.5961446203512955 0.8577080896540498 0.8062763059242399 0.8852540354822348 0.8278938140502289 1.1467086078563289 0.7500533536910486 0.8058750461707257 0.987746425199541 1.0 9.836129867225086 -4.20009205126738 1.0495352900553465 0.9036153494015725 3.727907207867706e-16 0.4039309787910267 0.1110560915435747 5.7425367371650955 2.1969685040024305 0.0346732000025255 7.7908821568734465 6.308236235354575e-05 4.20009205126738 -0.9036153494015722 RLS(ph)NPCIQR ddPTM_A459_Selumetinib_30min_R2 1 RLSNPCIQR 9 1 Q5RGS4;Q9HB21-2 Q5RGS4 PLEKHA1 Pleckstrin homology domain-containing family A member 1 1 RLS(1)NPCIQR 92.611 0.046085 13742000.0 27120.0 28427.0 28858.0 34855.0 30230.0 22419.0 25624.0 23897.0 22035.0 27649.0 True False 25612.77896996174 30607.25949278834 27001.307698214703 30107.68887177129 26432.23714037107 25507.0137505807 26815.566772992745 23966.53631363867 26442.61570934138 26850.701529270682 0.9538960813385285 1.139905393511694 1.005609021752368 1.1212998974700932 0.9844151413160125 0.9499570699400464 0.9986914771578822 0.892585107599967 0.9848016700984725 1.0 14.712672161599178 -6.454542303952486 7.2549644557604385 0.9612398615819638 1.0575517115719486 0.35916900689762865 0.05709276907751394 0.2663412091533715 24.733245264864376 0.016519979650243904 0.01865728737025708 3.5112172062774647e-07 6.454542303952486 0.09631184998998477 RLS(ph)NVSLPGPGLSVPR ddPTM_A459_Selumetinib_30min_R2 1 RLSNVSLPGPGLSVPR 16 1 O94806;O94806-2;C9JKP8 O94806 PRKD3 Serine/threonine-protein kinase D3 1 RLS(0.746)NVS(0.254)LPGPGLSVPR 79.695 0.012465 4879300.0 13388.0 11604.0 13096.0 15611.0 17149.0 12881.0 10960.0 14442.0 11400.0 11029.0 True False 12643.948556410329 12493.98948725916 12253.417617846688 13484.754869522916 14994.589305994825 14655.240827924083 11469.661716827994 14484.023828998188 13680.31854261365 10710.564113216617 1.180511915409568 1.166510872367762 1.1440496960123905 1.2590144391071807 1.3999812845984283 1.3682977547223507 1.0708737276195066 1.3523119488286521 1.27727339083218 1.0 13.38674684674384 -5.77362208870813 19.020701136962188 1.265613935167242 1.1639730702660611 0.07645320099960795 0.12060100392352027 25.516898382242953 39840.885144261156 0.033211442327809704 0.05003010409158409 1.6841389156959188e-06 5.77362208870813 -0.10164086490118085 RLS(ph)PPACTLR ddPTM_A459_Selumetinib_30min_R1 2 RLSPPACTLR 10 1 P28360 P28360 MSX1 Homeobox protein MSX-1 1 RLS(1)PPACTLR;RLS(1)PPACTLR 86.898 0.017667 43621700.0 3497.4 3928.3 6341.8 7284.700000000001 5082.700000000001 4242.5 4177.8 4068.8999999999996 2489.8 2679.3 True False 3578.8826152442493 3468.372809782875 5480.618393013866 6012.563895754836 4622.97068242357 4199.824301881798 3862.6651824339233 3960.979554350112 4225.008752202874 3023.2142535920643 1.1838005232318423 1.1472467773866475 1.8128448509734336 1.9887984745411094 1.5291574776517205 1.3891917507638543 1.2776683550775325 1.310188171296107 1.3975221065403767 1.0 11.561867510283856 -6.947330275551699 2.9597779850856156 1.2747893006440838 1.551277142282261 0.21399409172379902 0.25502623578578787 0.49702393885029833 8.866655713952106 0.11153678428592527 0.09331494574125801 1.1289370455532135e-07 6.947330275551699 0.2764878416381773 RLS(ph)PPSSSAASSYSFSDLNSTR ddPTM_A459_Selumetinib_30min_R1 2 RLSPPSSSAASSYSFSDLNSTR 22 1 P50402 P50402 EMD Emerin 1 RLS(0.979)PPS(0.016)S(0.002)S(0.002)AASSYSFSDLNSTR;RLS(0.97)PPS(0.01)S(0.01)S(0.01)AASSYSFSDLNSTR 73.404 0.0012349 53929000.0 2368.7 3037.4 2834.8 2415.3 2748.2 2709.7 2891.0 2477.2 1209.1100000000001 2150.8999999999996 True False 2423.8861013121304 2681.7797959510503 2449.849730441783 1993.513195796211 2499.6257952341184 2682.44287821075 2672.9295424425477 2411.4966089203704 2051.771360099613 2426.9889665402043 0.9987215165495799 1.1049822775972744 1.0094193934198916 0.8213935964604178 1.0299287840593119 1.1052554894943376 1.1013356794336582 0.9936166345074411 0.8453978935983862 1.0 11.24495183445566 -8.015560756780838 23.84185188370372 0.921635005147466 1.0242515024666694 0.18116996257366047 0.08545734438728421 673.8920855301958 1032513.1406576146 0.05790751385052034 0.023441692119149336 9.648043284980323e-09 8.015560756780838 0.10261649731920341 RLS(ph)PPSSSAASSYSFSDLNSTR ddPTM_A459_Selumetinib_30min_R2 1 RLSPPSSSAASSYSFSDLNSTR 22 1 P50402 P50402 EMD Emerin 1 RLS(0.825)PPS(0.153)S(0.016)S(0.007)AASSYSFSDLNSTR 71.946 0.0016596 20321000.0 46423.0 32623.0 38129.0 39440.0 23004.0 27730.0 57469.0 50474.0 35070.0 34896.0 True False 43842.99550599314 35125.07920052185 35675.8216517163 34068.20396220511 20114.031861630716 31549.555792122905 60141.42237266316 50620.87098357949 42084.979937672 33888.4618093034 1.29374404045559 1.03649080911896 1.0527424305201782 1.0053039336489555 0.5935362889828423 0.9309822313464108 1.7746872876995714 1.4937494439385424 1.241867517460424 1.0 15.048506534209883 -7.2307078155670474 24.721287295865025 1.418721908536543 0.973930512371527 0.3763672290698088 0.24472035114947177 575.7684434659262 463164.00804670446 0.09561117553865299 0.07405087327574689 5.878847363223586e-08 7.2307078155670474 -0.44479139616501606 RLS(ph)PQLQHNITEDAYCETHLEPTR ddPTM_A459_Selumetinib_30min_R1 2 RLSPQLQHNITEDAYCETHLEPTR 24 1 Q8N7C3-2 Q8N7C3-2 1 RLS(0.967)PQLQHNIT(0.032)EDAYCETHLEPTR;RLS(0.998)PQLQHNIT(0.002)EDAYCETHLEPTR 121.35 1.0274e-07 25175700.0 5728.91 4578.55 6276.709999999999 6996.57 4625.49 4919.45 4520.37 4241.89 2970.13 3656.53 True False 5862.3824564816505 4042.4912374898545 5424.367257500086 5774.750391384874 4207.115246196588 4869.964799503216 4179.394851529235 4129.381297599401 5040.093680287699 4125.881243118348 1.4208800765314447 0.979788558924816 1.3147172538103256 1.3996404770536508 1.0196888854262909 1.1803453644299489 1.0129702250883115 1.000848316826106 1.2215799203368218 1.0 12.010486580818638 -6.278551837934787 24.985324430562645 1.0750230974018058 1.2599703599575471 0.361679851651843 0.13323409614104265 995.832626763482 1453978.5397116859 0.040813294724706156 0.04639101398480575 5.265603602368662e-07 6.278551837934787 0.18494726255574134 RLS(ph)PQPQIR ddPTM_A459_Selumetinib_30min_R1 1 RLSPQPQIR 9 1 J3QT39;Q49A88;A0A0A0MR27;Q49A88-2;Q49A88-3;Q49A88-5;Q49A88-6;C9JU82 J3QT39 CCDC14 Coiled-coil domain-containing protein 14 1 RLS(1)PQPQIR 70.72800000000002 0.03722 9647200.0 1290.7 1052.3 1228.6 1223.3 1252.1 1126.2 1094.9 1042.3 697.62 902.68 True False 1320.7707987349897 929.0962267990018 1061.7628682167256 1009.6736191849895 1138.8477760762096 1114.8714505077855 1012.3108114909534 1014.6548181324495 1183.8101878511395 1018.5477708477904 1.2967195418194704 0.9121773699682898 1.0424281497695145 0.9912874467778625 1.1181093402504698 1.094569623945885 0.9938766157706618 0.9961779380145316 1.1622529858032997 1.0 9.992297930306098 -7.038976383968624 0.006643195258064632 1.6011127013534313e-07 2.1055209651618214 0.03642825187531695 0.10294586104826259 24193.563661159667 78.36280218410441 12243.653384334426 12586.459664796013 9.141629504001352e-08 7.038976383968624 2.1055208050505514 RLS(ph)PQPQIR ddPTM_A459_Selumetinib_30min_R2 3 RLSPQPQIR 9 1 J3QT39;Q49A88;A0A0A0MR27;Q49A88-2;Q49A88-3;Q49A88-5;Q49A88-6;C9JU82 J3QT39 CCDC14 Coiled-coil domain-containing protein 14 1 RLS(1)PQPQIR;RLS(1)PQPQIR;RLS(1)PQPQIR 85.522 0.017999 29842400.0 28702.2 26871.5 34409.2 39904.3 35138.9 20795.6 22031.5 25029.9 21225.7 28049.4 True False 27107.046628010172 28932.457644509166 32195.349533904267 34469.265501242946 30724.437236248265 23660.005136338656 23056.00840458904 25102.73286507698 25471.433095610046 27239.54094090656 0.9951359564691702 1.0621492376569495 1.1819343653312233 1.2654128634553916 1.1279352065037305 0.8685904504656173 0.8464169221723202 0.9215549160514427 0.9350903949103897 1.0 14.733414769835624 -6.7549011492646045 24.92861742673922 0.9051831106589172 1.13373334447075 0.65481349924952 0.07679530801321802 95.32338847813025 363443.6110843379 0.027976427641164436 0.02734654571023187 1.7583237844123185e-07 6.7549011492646045 0.22855023381183281 RLS(ph)QPAGGLLDSITNIFGR ddPTM_A459_Selumetinib_30min_R1 1 RLSQPAGGLLDSITNIFGR 19 1 Q676U5-4;Q676U5-3;Q676U5 Q676U5-4 ATG16L1 Autophagy-related protein 16-1 1 RLS(1)QPAGGLLDSITNIFGR 153.57 5.8276e-06 1525900.0 339.52 281.23 326.21 295.56 236.83 323.13 343.52 152.05 59.285 0.0 True False 347.43015540908306 248.30346085971993 281.91247374326724 243.94599434833262 215.40876831573254 319.87960557856576 317.6080098304612 148.01714007199354 100.6023149949182 0.0 0.0 RLS(ph)QPESAEK ddPTM_A459_Selumetinib_30min_R1 3 RLSQPESAEK 10 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 RLS(0.999)QPES(0.001)AEK;RLS(1)QPESAEK;RLS(1)QPESAEK 176.99 0.0001365 137354800.0 8232.3 9274.5 10134.099999999999 11370.5 8900.8 8202.8 10426.5 9719.5 5519.5 8054.4 True False 8424.096572732664 8188.637228401921 8757.944882626669 9384.855625719705 8095.724211563875 8120.287279546493 9640.020710576686 9461.707286614543 9366.188371669916 9088.260696499796 0.9269206566639396 0.9010125811593024 0.9636546722300403 1.0326349495381595 0.89078917098866 0.8934918958336986 1.0607112881664356 1.0410910957097186 1.0305809532155212 1.0 13.149788503764485 -7.268302742276778 24.851408726588936 1.0365200959526288 0.9369819610247955 0.5727781200668949 0.041540602144371476 402.77621290154224 1458397.1391135512 0.01837416814688105 0.012696569987455773 5.3913466618719654e-08 7.268302742276778 -0.09953813492783337 RLS(ph)QPESAEK ddPTM_A459_Selumetinib_30min_R2 4 RLSQPESAEK 10 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 RLS(1)QPESAEK;RLS(1)QPESAEK;RLS(1)QPESAEK;RLS(1)QPESAEK 120.9 0.002539 177049000.0 430430.0 372166.0 427046.0 417835.0 395689.0 295783.0 348964.0 403704.0 374037.0 415711.0 True False 406508.4237478112 400709.93549769925 399570.32529252965 360925.1521944211 345979.0103154577 336524.4233992601 365191.51745904825 404878.711803205 448854.8514669817 403708.34328310733 1.006935899421678 0.9925728367141885 0.9897499814917726 0.8940245060561361 0.8570023782561116 0.8335830284371077 0.9045924453509535 1.0028990446681876 1.1118295148837551 1.0 18.62295387717989 -7.94369845550178 4.363560157117902 1.0573009853387076 0.9236672012667091 0.43904705528692256 0.06022067458919709 0.20630848445520972 8.030846076646682 0.04157176211863285 0.01822020352503231 1.1384174509868327e-08 7.94369845550178 -0.13363378407199855 RLS(ph)QRPTPEELEQR ddPTM_A459_Selumetinib_30min_R2 3 RLSQRPTPEELEQR 14 2 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 RLS(0.991)QRPT(0.009)PEELEQR;RLS(0.967)QRPT(0.033)PEELEQR;RLS(0.965)QRPT(0.035)PEELEQR 86.944 0.0088791 28964800.0 38972.0 39174.0 40982.0 48521.0 38447.0 29709.600000000002 32245.5 33515.0 34500.0 33050.1 True False 36806.09225727691 42178.51983573685 38345.26273782784 41912.35609660634 33616.944139459054 33801.827723103284 33744.97964324607 33612.52310129307 41400.96401054128 32095.857738527582 1.1467552154898546 1.3141421606286012 1.1947106399277976 1.3058493852399875 1.0473919847639894 1.053152341291938 1.0513811445125798 1.047254239943396 1.2899161115374689 1.0 14.970099496034177 -6.267959715227117 24.975099217408314 1.0809537558686813 1.2423732156928382 0.4475759188260343 0.08644236345264973 468.80994073060856 1795697.891040433 0.02582007869866436 0.029973440563530733 5.395606693654772e-07 6.267959715227117 0.16141945982415695 RLS(ph)QSDEDVIR ddPTM_A459_Selumetinib_30min_R1 2 RLSQSDEDVIR 11 1 H0Y917;A0A499FIZ0;Q9H7D7-3;Q9H7D7-4;Q9H7D7-2;Q9H7D7 H0Y917 WDR26 WD repeat-containing protein 26 1 RLS(0.999)QS(0.001)DEDVIR;RLS(0.999)QS(0.001)DEDVIR 149.32 0.00032508 60858000.0 4650.2 5123.5 4978.200000000001 5099.3 5000.2 4604.1 5181.5 4210.0 2853.68 3482.0 True False 4758.540612285925 4523.63823814947 4302.1877832952205 4208.802980716106 4547.932792857008 4557.786934188325 4790.655283350416 4098.337123992719 4842.486535459189 3928.9486175521815 1.2111485986422996 1.1513610073546325 1.094997212250532 1.0712288172753655 1.1575444821394654 1.1600525682180907 1.2193224573995818 1.0431129350187507 1.232514600426656 1.0 11.93992758514197 -11.008271931373146 3.099991139231454 0.9963252132531033 1.1447490446578321 0.35306445443222256 0.06027013728791121 15567437.717978884 20717732.388262417 497342.02009091777 0.014685878019632006 9.811334187411485e-12 11.008271931373146 0.1484238314047288 RLS(ph)QSDEDVIR ddPTM_A459_Selumetinib_30min_R2 4 RLSQSDEDVIR 11 1 H0Y917;A0A499FIZ0;Q9H7D7-3;Q9H7D7-4;Q9H7D7-2;Q9H7D7 H0Y917 WDR26 WD repeat-containing protein 26 1 RLS(0.991)QS(0.009)DEDVIR;RLS(1)QSDEDVIR;RLS(0.999)QS(0.001)DEDVIR;RLS(1)QSDEDVIR 152.88 0.00058581 92250300.0 129413.0 123217.0 133359.0 154165.0 160028.0 121873.0 117533.0 130380.0 116295.0 140220.0 True False 122220.74354128553 132667.3476948992 124778.8271303006 133167.46105054163 139923.85197152838 138659.89949705714 122998.51738722126 130759.38421442913 139557.24955379413 136171.4842646874 0.8975502044445318 0.9742667373517282 0.9163359553881194 0.9779394105133891 1.0275561930392652 1.0182741287267811 0.9032619277920126 0.960255261375147 1.024863981672738 1.0 17.05506509396048 -5.850228847641837 6.367819260814541 0.9857248168209909 0.9340875326669651 0.31514975491501684 0.03909023541649228 0.3013342288112535 17.613085781118905 0.011638181694053246 0.01747616957373829 1.4117934165112998e-06 5.850228847641837 -0.0516372841540258 RLS(ph)SASTGKPPLSVEDDFEK ddPTM_A459_Selumetinib_30min_R1 1 RLSSASTGKPPLSVEDDFEK 20 2 O75152;A0A1B0GTU1;A0A494C0C4 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 RLS(0.614)S(0.261)AS(0.062)T(0.062)GKPPLS(0.001)VEDDFEK 69.084 0.014188 26782000.0 1255.4 1366.6 1514.0 1532.4 1426.0 1147.4 1643.6 1969.6 1214.9 1307.0 True False 1284.6483774168325 1206.5978366848965 1308.4071158067104 1264.7951067106003 1297.0185517807488 1135.858197755846 1519.6219287300485 1917.3598098375421 2061.596567214744 1474.766181258099 0.871086138089307 0.8181621276774651 0.8871963111403393 0.8576241595339704 0.8794740266380962 0.7701954467025165 1.030415497752792 1.3001110509612266 1.3979141869499812 1.0 10.526270523286302 -7.561056342063428 3.6212928365457304 1.2590468809023474 0.8510469743564819 0.7475813240233694 0.09995563534306694 0.10216917139087771 2.8312356296655334 0.047888210977143 0.0268871001681468 2.7475376853349335e-08 7.561056342063428 -0.4079999065458655 RLS(ph)SDCSVTQER ddPTM_A459_Selumetinib_30min_R1 2 RLSSDCSVTQER 12 1 E7EX48;P51957-3;P51957-2;P51957 E7EX48 NEK4 Serine/threonine-protein kinase Nek4 1 RLS(0.964)S(0.036)DCSVTQER;RLS(0.97)S(0.029)DCS(0.001)VTQER 183.28 0.00018729 23186000.0 3592.6 3885.1000000000004 4162.1 4251.7 3780.3 3822.6 3036.6 3101.6 2150.66 2782.3 True False 3676.3005900172943 3430.2306858660095 3596.9096807788014 3509.220409293567 3438.3725324661746 3784.1481146431015 2807.546817219313 3019.335492583328 3649.5129420084477 3139.435306897024 1.171006958461871 1.0926266511465095 1.145718681597532 1.1177871388476017 1.0952200623189832 1.2053594817926996 0.8942840169540729 0.9617447717269889 1.1624743258734571 1.0 11.61628936823647 -7.251940123341548 24.98328992697346 1.0014378399715032 1.1333867918891434 0.4639507923727726 0.07007222781650059 615.761476311755 1619470.624944074 0.026828257559047233 0.02051170053772848 5.5983478121232066e-08 7.251940123341548 0.13194895191764022 RLS(ph)SDCSVTQER ddPTM_A459_Selumetinib_30min_R2 2 RLSSDCSVTQER 12 1 E7EX48;P51957-3;P51957-2;P51957 E7EX48 NEK4 Serine/threonine-protein kinase Nek4 1 RLS(0.967)S(0.033)DCSVTQER;RLS(0.975)S(0.024)DCS(0.001)VTQER 153.0 0.002706 0.0 17161.6 19139.8 20508.0 23146.0 23618.0 16453.4 16485.1 20160.2 21381.7 22893.9 True False 16207.826975328002 20607.761115843066 19188.537607422124 19993.47487092292 20650.89569240107 18719.706500905682 17251.68981460595 20218.862844299216 25658.637454614243 22232.89362150421 0.7290021376098066 0.9269041388256689 0.8630697350552018 0.8992745259026802 0.9288442630979447 0.8419824616441072 0.7759534187632547 0.9094121165021465 1.154084479124956 1.0 14.44040810756881 -8.111800339080538 5.327816947817888 1.0729770918642942 0.8587354696730679 0.6222755257565071 0.0688454327151845 0.14415195858011937 5.712576742546604 0.04723666526166391 0.017218269748025962 7.730358960440051e-09 8.111800339080538 -0.21424162219122633 RLS(ph)SFVTK ddPTM_A459_Selumetinib_30min_R2 1 RLSSFVTK 8 1 P27708;F8VPD4;H7C3Z5 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 RLS(0.776)S(0.174)FVT(0.05)K 72.34 0.033993 3699500.0 42766.0 34561.0 42559.0 41075.0 35456.0 27053.0 37304.0 31233.0 25043.0 40013.0 True False 40389.236925862235 37211.7175688697 39820.80027473558 35480.51414167279 31001.700299338318 30779.305187317015 39038.70991647366 31323.882859098514 30052.29975988364 38857.72072374073 1.0394134337680234 0.9576402546466043 1.0247847669152257 0.9130878878337149 0.7978260104277641 0.7921026919242826 1.0046577408391932 0.8061173500575576 0.7733932716625533 1.0 15.245913658831043 -5.938602132664345 4.353491275311029 0.8559355499630639 1.001157269209059 0.39413902330762884 0.07983148465258934 0.21313317911243113 8.199682113362602 0.022880005323989833 0.03441408930447239 1.1518551471755293e-06 5.938602132664345 0.14522171924599503 RLS(ph)SSS(ph)ATLLNSPDR ddPTM_A459_Selumetinib_30min_R2 1 RLSSSSATLLNSPDR 15 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 2 RLS(0.999)S(0.12)S(0.037)S(0.572)AT(0.264)LLNS(0.008)PDR 128.74 0.0040741 0.0 46507.0 52110.0 49354.0 53540.0 57992.0 47647.0 47255.0 46367.0 39453.0 47878.0 True False 43922.32712227182 56106.66943994095 46178.61737257222 46247.759638348434 50706.526504942114 54209.941753598236 49452.45113400609 46501.92029352994 47344.70240892422 46495.637738016616 0.9446547947090366 1.2067082455364622 0.9931817180951324 0.9946687880470665 1.0905652437902258 1.165914575880182 1.063593350684851 1.0001351213967367 1.0182611684066305 1.0 15.50480774719059 -7.729472731925594 6.834726676422702 1.006822678526659 1.070560719151078 0.11513516514477162 0.07475566104177862 0.3772738913875454 55.31893894229685 0.03631887627720609 0.02021407672299245 1.864349231587868e-08 7.729472731925594 0.06373804062441901 RLS(ph)STSLASGHSVR ddPTM_A459_Selumetinib_30min_R1 4 RLSSTSLASGHSVR 14 1 Q9BZL6-2;Q9BZL6;Q9BZL6-3;M0QZ82 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 RLS(0.963)S(0.03)T(0.007)SLASGHSVR;RLS(0.874)S(0.111)T(0.015)SLASGHSVR;RLS(0.799)S(0.152)T(0.049)SLASGHSVR;RLS(0.938)S(0.052)T(0.009)SLASGHSVR 165.24 0.00013065 167964000.0 5837.6 6942.7 7047.549999999999 8076.219999999999 7781.7 6770.23 7772.049999999999 6528.7 3694.47 4975.55 True False 5973.60472200773 6129.845456426332 6090.531419421117 6665.859786425401 7077.8466089707235 6702.127633077003 7185.798011186645 6355.53766779365 6269.245756587254 5614.2103084611645 1.0640151319242392 1.0918446441502299 1.084842049868009 1.187319216805843 1.2607020792049268 1.1937792253660753 1.279930322588191 1.1320448146046886 1.116674547645443 1.0 12.454867392917764 -5.757551865678282 18.51610707066052 1.1824087999867394 1.081394003304648 0.20200115154159826 0.07506484383405944 5.1452926084905934 24488.65282832484 0.020310364180717924 0.033290344253119615 1.7476245396538842e-06 5.757551865678282 -0.10101479668209135 RLS(ph)STSLASGHSVR ddPTM_A459_Selumetinib_30min_R2 3 RLSSTSLASGHSVR 14 1 Q9BZL6-2;Q9BZL6;Q9BZL6-3;M0QZ82 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 RLS(0.835)S(0.163)T(0.003)SLASGHSVR;RLS(0.975)S(0.024)T(0.001)SLASGHSVR;RLS(0.98)S(0.02)TSLASGHSVR 156.06 0.00016618 117300000.0 31690.7 30775.4 41187.5 52556.5 50045.0 37419.0 28175.9 33249.6 33904.1 44672.9 True False 29929.457761923564 33135.77422149222 38537.541091559295 45398.21403498054 43757.899692023486 42573.127594138 29486.135179486657 33346.35083123238 40685.86735970417 43383.0773028665 0.6898878461981764 0.7637949237709516 0.8883081488784328 1.0464498338383408 1.0086398294556256 0.9813302845468046 0.6796690556005899 0.7686488120341121 0.9378280631331768 1.0 15.404844771243894 -5.158121164074958 3.0372280918306447 0.9085072675763416 0.7026065471976977 0.33462556808887145 0.10771841980848547 0.3600480241778067 6.188831699897818 0.03220046614827975 0.11309064940319177 6.948304393887742e-06 5.158121164074958 -0.20590072037864393 RLS(ph)TIFEECDEELER ddPTM_A459_Selumetinib_30min_R2 1 RLSTIFEECDEELER 15 1 Q5T5P2-3;Q5T5P2;A0A0U1RRK8 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 RLS(0.98)T(0.02)IFEECDEELER 122.46 0.00079861 1797600.0 916.8 868.86 756.86 796.21 716.73 807.01 762.77 1156.3 592.24 1192.8 True False 865.8479262411846 935.4987681747671 708.1644516068604 687.7648244611391 626.6879697525028 918.1683021926102 798.2403164000815 1159.66464156423 710.7045485682024 1158.3607647334102 0.7474769109953878 0.80760571029015 0.6113505163219511 0.5937397444736693 0.5410127732500775 0.7926445112321472 0.6891120113031381 1.0011256224058311 0.6135433538546748 1.0 10.177868926965212 -6.918040945628221 9.457807784371933 0.8139524849591946 0.6620127022357769 0.26547795245061234 0.13257965632265892 0.48269951019561064 51.265413683509195 0.046369861622245455 0.0408966107098465 1.207699966828292e-07 6.918040945628221 -0.15193978272341768 RLS(ph)TPQR ddPTM_A459_Selumetinib_30min_R2 1 RLSTPQR 7 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 RLS(0.813)T(0.187)PQR 80.755 0.022743 38368000.0 20092.0 20122.0 20077.0 26040.0 23370.0 17697.0 17441.0 15179.0 21223.0 24125.0 True False 18975.367074648646 21665.292697572273 18785.267678184788 22493.30707849446 20434.05166954918 20134.601112628865 18252.041058685852 15223.168376981279 25468.19302016573 23428.448565722265 0.8099284517887864 0.9247429524322138 0.8018144106080148 0.9600852150066824 0.8721897061270146 0.8594082128889845 0.7790546184688507 0.6497727894476981 1.0870627198690304 1.0 14.5159738014993 -8.292393753888213 24.999933555787155 1.043531456280817 0.8389427806332924 0.5078277899425792 0.083032264043804 675.6359370753445 545663.2191913995 0.0822059742542025 0.02123489287287591 5.100423594399024e-09 8.292393753888213 -0.20458867564752448 RLS(ph)TSPDVIQGHQPR ddPTM_A459_Selumetinib_30min_R2 2 RLSTSPDVIQGHQPR 15 1 Q9Y385 Q9Y385 UBE2J1 Ubiquitin-conjugating enzyme E2 J1 1 RLS(0.989)T(0.009)S(0.002)PDVIQGHQPR;RLS(0.994)T(0.006)SPDVIQGHQPR 129.43 0.000889 10815000.0 27608.0 11452.400000000001 16797.0 24290.1 15725.2 14721.599999999999 26141.0 14203.2 25328.0 19177.6 True False 26073.65788358053 12330.762254729992 15716.299307190806 20981.74647724033 13749.659790928317 16749.366770620858 27356.608297408802 14244.528960533667 30394.307723448976 18623.892858611212 1.4000111620876694 0.6620937066349457 0.8438783140831907 1.1266036932519672 0.738280653530007 0.8993483208789176 1.4688985007105968 0.7648523898131943 1.6320061522151328 1.0 14.1848670432522 -7.209136865336281 24.97837777727878 1.196844191292734 0.9264318817488024 0.16665694545932275 0.29426423100786864 581.7741990150024 277840.9004545493 0.10513131190844548 0.08143431475211454 6.178216666128442e-08 7.209136865336281 -0.2704123095439315 RLS(ph)VELT(ph)S(ph)S(ph)LFRT(ph)EP ddPTM_A459_Selumetinib_30min_R2 1 RLSVELTSSLFRTEP 15 2 A0A2R8Y6G0 A0A2R8Y6G0 5 RLS(1)VELT(1)S(1)S(1)LFRT(1)EP 43.557 0.039462 8357400.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RLS(ph)VELTSSLFR ddPTM_A459_Selumetinib_30min_R1 1 RLSVELTSSLFR 12 1 A0A2R8Y6G0;A0A2R8Y804;A0A2R8Y543;A0A2R8Y5C3;A0A2R8Y750;A0A2R8Y5Z1;B4DGU4;A0A2R8YCH5;A0A2R8Y5A3;P35222;A0A2R8YG06;A0A2R8Y7Z0 A0A2R8Y6G0 CTNNB1 Catenin beta-1 1 RLS(1)VELTSSLFR 77.562 0.023418 18336000.0 1008.8 1383.1 1563.7 1301.3 1315.1 1092.1 1028.3 1241.2 558.63 801.61 True False 1032.3030772169034 1221.1660090142539 1351.3581287892687 1074.0523834263277 1196.1494371997633 1081.1144655474625 950.7345031109198 1208.2793440141959 947.954309279095 904.5044518426201 1.1412913171559709 1.3500939730330166 1.4940314843518305 1.1874484213298357 1.3224362077632847 1.1952561022171417 1.0511109162305632 1.3358467628907051 1.048037195779369 1.0 9.82098379337908 -6.902400170326667 4.0058456784828405 1.1348083444370842 1.3063999551722574 0.33710664078816377 0.12340676352576144 0.2891949698187063 8.681093698978023 0.04483582019181637 0.03912245156874507 1.2519870296059345e-07 6.902400170326667 0.17159161073517315 RLS(ph)YNTASNK ddPTM_A459_Selumetinib_30min_R2 4 RLSYNTASNK 10 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 RLS(0.958)YNT(0.042)ASNK;RLS(0.967)YNT(0.032)AS(0.001)NK;RLS(0.966)Y(0.002)NT(0.031)ASNK;RLS(0.591)YNT(0.408)ASNK 109.0 0.011305 34317000.0 210599.0 191606.0 226743.0 214813.0 211759.0 74019.7 124097.6 154040.2 105941.0 206845.0 True False 198894.75067459344 206301.56408960474 212154.6022391122 185555.0988269059 185155.94127052042 84215.24179106376 129868.3842947293 154488.43147927194 127132.16023886255 200872.8474021484 0.9901524932157962 1.0270256371513866 1.0561636626496247 0.9237440561362864 0.9217569405975379 0.4192465177857734 0.646520353419057 0.7690856851846449 0.6328986813451364 1.0 17.615923038180938 -6.545071562319168 23.726219970204745 0.6755477055671603 0.9949967731643659 0.5264114854098847 0.13864996340585137 96.78491884573882 103471.0094213691 0.04450991190709886 0.044514225623983626 2.8505485201800337e-07 6.545071562319168 0.3194490675972056 RLS(ph)YQGQSR ddPTM_A459_Selumetinib_30min_R2 1 RLSYQGQSR 9 1 Q9BW04-2;Q9BW04 Q9BW04-2 SARG Specifically androgen-regulated gene protein 1 RLS(1)YQGQSR 79.23 0.025396 3256500.0 4280.7 6179.3 5522.4 8666.2 9275.2 9044.3 5757.9 7689.8 5085.8 8340.6 True False 4042.7958309998266 6653.232440418867 5167.094796334499 7485.848609971142 8109.96645465994 10290.07022901901 6025.653759062402 7712.176044885077 6103.102109124959 8099.78520651868 0.4991238320426322 0.8214085029149129 0.6379298542603374 0.924203348497014 1.0012569775471412 1.2704127290607157 0.7439275987482947 0.9521457480969179 0.7534893770038744 1.0 12.983667935177984 -5.802541381250552 5.8104051281931985 0.9561892153123184 0.6691776133200171 0.4312662952769395 0.15573709170871908 0.18272979219052657 15.20729580478468 0.04453587653462284 0.06848450245001145 1.575645881984147e-06 5.802541381250552 -0.28701160199230125 RLSDS(ph)PVFDAPPSPPDSLSDR ddPTM_A459_Selumetinib_30min_R2 2 RLSDSPVFDAPPSPPDSLSDR 21 1 P47974 P47974 ZFP36L2 Zinc finger protein 36, C3H1 type-like 2 1 RLS(0.259)DS(0.741)PVFDAPPSPPDSLSDR;RLS(0.171)DS(0.829)PVFDAPPSPPDSLSDR 136.37 1.7199000000000006e-05 11511600.0 72063.0 52856.0 78163.0 79854.0 78359.0 64651.0 56260.0 71884.0 58249.0 60605.0 True False 68058.02695104542 56909.8852411729 73134.07767743985 68977.74744416667 68514.84188165188 73556.08840665479 58876.201477075054 72093.17053896324 69900.42761304419 58855.17617929942 1.1563643398791292 0.9669478359524354 1.242610802058267 1.1719911810989967 1.1641260179550692 1.2497811268556864 1.0003572378699808 1.2249248956342416 1.1876683097523308 1.0 15.844881682150723 -5.266348447919716 24.998584971151246 1.161984253654376 1.061656089759896 0.1324628881862796 0.09446499839738647 671.5279447170908 3419649.3005682495 0.023183440980303553 0.05074260544342336 5.415662006988467e-06 5.266348447919716 -0.10032816389448018 RLSELLR ddPTM_A459_Selumetinib_30min_R1 2 RLSELLR 7 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 ; 125.81 0.0080069 21110000.0 3648.8 4925.5 4968.5 4868.8 4271.2 4086.8 4513.9 3785.6 3023.0 3592.5 False True 3733.809940671129 4348.820170197173 4293.8049900169335 4018.5554786952307 3884.8707141416044 4045.6905025175056 4173.412888838258 3685.1935906382014 5129.810208815683 4053.6323689133324 0.9211022610992375 1.0728205654631113 1.0592487426697712 0.9913468003445254 0.9583677947546664 0.9980408025017928 1.0295489351337097 0.9091089806020324 1.2654848150896438 1.0 11.984999538835568 -8.249609734015662 24.95957721379366 1.1327424304314222 0.9976042792908986 0.3390295610536366 0.07809092688758251 703.8282449987703 1485028.3814784181 0.05029542651024489 0.018657026578814365 5.628468838293677e-09 8.249609734015662 -0.13513815114052363 RLSES(ph)SALK ddPTM_A459_Selumetinib_30min_R2 1 RLSESSALK 9 1 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 RLS(0.12)ES(0.874)S(0.006)ALK 91.123 0.014188 19691000.0 63998.0 36862.0 60600.0 69432.0 67676.0 56716.0 83459.0 89874.0 75548.0 67678.0 True False 60441.247364292474 39689.19686998857 56701.06197629119 59975.24182311934 59173.93584888369 64528.11418341296 87340.00887087121 90135.51846055825 90659.71098748899 65723.96029143839 0.9196227235285139 0.6038771354312125 0.8627152369525947 0.9125323787120005 0.9003403870748192 0.9818050205325012 1.3288914496871649 1.3714255510604079 1.3794012196690297 1.0 16.004131794114336 -7.062135130892653 2.223544566800422 1.3049499858331897 0.8271195001642858 0.6939486993386186 0.13362439942897342 0.16435025927050065 1.6101762093668728 0.058348877499023906 0.043946117670117094 8.666921622048872e-08 7.062135130892653 -0.47783048566890385 RLSLES(ph)EGAGEGAAASPELSALEEAFR ddPTM_A459_Selumetinib_30min_R1 1 RLSLESEGAGEGAAASPELSALEEAFR 27 1 O94811 O94811 TPPP Tubulin polymerization-promoting protein 1 RLS(0.213)LES(0.787)EGAGEGAAASPELSALEEAFR 74.627 7.7232e-05 20210000.0 1488.8 1623.4 1460.1 1404.0 1423.1 1307.6 1300.0 1442.2 858.85 1600.8 True False 1523.4861432994899 1433.3315733018146 1261.826439755202 1158.8177563440897 1294.380856268711 1294.4467312058068 1201.9399533639948 1403.9481710741804 1457.4057220778532 1806.2782731124457 0.8434393337823473 0.7935275503436152 0.6985780975934099 0.6415499613729507 0.7166010218560229 0.7166374918385701 0.6654234683855774 0.7772601774448631 0.8068555901780067 1.0 10.818804454509248 -8.70369846573775 1.4776763111375313 0.9991094730271154 0.7239330855227402 0.6765668800796889 0.05639507139887662 0.4283763111965826 1.821665504123719 0.05853129231113298 0.017128804107171103 1.9783427431597284e-09 8.70369846573775 -0.27517638750437523 RLSLPGLLSQVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 RLSLPGLLSQVSPR 14 1 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 RLSLPGLLS(0.001)QVS(0.999)PR 120.08 0.0010879000000000002 14758000.0 3707.9 3748.6 5147.7 5101.1 4478.4 3981.5 3837.8 3967.4 2534.5 2971.1 True False 3794.28685568255 3309.71216932314 4448.670614292071 4210.288644506296 4073.3295107257363 3941.4497249127594 3548.3116561694924 3862.1716640685786 4300.861387444044 3352.469625964758 1.1317885854344312 0.9872459823914695 1.3269831230795577 1.2558767458764608 1.2150235394164184 1.1756854392911933 1.058417242228817 1.1520377795987162 1.28289346878314 1.0 11.71100854574977 -7.026140743468065 24.171749036069418 1.1332989913902025 1.1855784528998652 0.06485522533771038 0.10683576642556104 1848.5602062892642 1709314.7611717947 0.042555141093704306 0.0330870439486768 9.415844042263684e-08 7.026140743468065 0.05227946150966267 RLSPQLQHNIT(ph)EDAYCETHLEPTR ddPTM_A459_Selumetinib_30min_R1 1 RLSPQLQHNITEDAYCETHLEPTR 24 1 Q8N7C3-2 Q8N7C3-2 1 RLS(0.104)PQLQHNIT(0.893)EDAY(0.003)CETHLEPTR 53.603 0.010596 22418000.0 541.53 599.88 776.47 800.44 715.57 629.68 803.25 579.79 381.24 439.61 True False 554.146595366048 529.6457707233543 671.0296388444098 660.6581801197027 650.8468198441448 623.3459909036959 742.6602057997153 564.4120857766601 646.936435332084 496.0382256640193 1.117144943062084 1.0677519258003683 1.352778080653238 1.3318694929918267 1.3120900490539649 1.256649102131709 1.497183417277079 1.1378399013929066 1.304206816855829 1.0 8.954307491537996 -5.254541805332412 24.76489640319918 1.2897672343558582 1.0924484107918995 0.2423727498534669 0.1260297069371367 572.2465010292807 2054565.1744898234 0.03020546514025007 0.07616942396305702 5.564910636636026e-06 5.254541805332412 -0.1973188235639587 RLSS(ph)ASTGKPPLSVEDDFEK ddPTM_A459_Selumetinib_30min_R1 1 RLSSASTGKPPLSVEDDFEK 20 2 O75152;A0A1B0GTU1;A0A494C0C4 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 RLS(0.164)S(0.815)AS(0.011)T(0.009)GKPPLSVEDDFEK 102.79 0.00070097 23465000.0 1251.8 2008.5 1803.6 1750.4 1336.9 1591.2 2502.1 2209.9 1598.5 1861.0 True False 1280.9645044212123 1773.343886273683 1558.6810264656415 1444.7254990774172 1215.9776310488655 1575.1939726940052 2313.3645825477324 2151.2862732331387 2712.537750179249 2099.8774776750747 0.6100186882519737 0.8444987410584923 0.7422723673341977 0.688004664289736 0.5790707524494056 0.7501361338653033 1.1016664577540136 1.0244818072028576 1.2917600093423043 1.0 11.03608943755002 -7.236820416865302 4.3144432880289 1.1103175823143754 0.7005560413754496 0.7984400994355869 0.09923170985885456 0.09226987906845774 4.19461724676477 0.04048459841670553 0.029411486182795023 5.796683428942529e-08 7.236820416865302 -0.4097615409389258 RLSS(ph)TSLASGHSVR ddPTM_A459_Selumetinib_30min_R2 1 RLSSTSLASGHSVR 14 1 Q9BZL6-2;Q9BZL6;Q9BZL6-3;M0QZ82 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 RLS(0.23)S(0.762)T(0.008)SLASGHSVR 101.08 0.0043861 11843000.0 8972.8 11580.0 13323.0 20624.0 17039.0 10257.0 10218.0 10576.0 10691.0 17044.0 True False 8474.127696964331 12468.148764431326 12465.812684985607 17814.975621615584 14898.408489407298 11669.808646224466 10693.157246582889 10606.774409048954 12829.498731498468 16551.89543436977 0.5119732498652649 0.7532761920753436 0.7531350554028108 1.0763103048985585 0.9001028642599427 0.7050436424333782 0.6460382310281337 0.6408193219384495 0.7751075266496791 1.0 14.014708815747353 -11.94274124058325 1.9755457619959726 2.6366859310425745 0.757651294667893 0.20733779815573716 0.14540038602050454 6514661.956298118 551316.7719163549 47635210.8539212 0.04049791879847183 1.1409293685771391e-12 11.94274124058325 -1.8790346363746815 RLSSS(ph)SATLLNSPDR ddPTM_A459_Selumetinib_30min_R2 1 RLSSSSATLLNSPDR 15 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 RLS(0.049)S(0.19)S(0.741)S(0.007)AT(0.013)LLNSPDR 124.46 0.0036167 0.0 6047.5 6394.4 6960.0 8357.3 8316.3 7904.2 6565.3 5964.9 4058.0 6566.3 True False 5711.404160060611 6884.829918763357 6512.20117747503 7219.021322853364 7271.532045334703 8992.931802816365 6870.599458895145 5982.256871457647 4869.713389993526 6376.71385770372 0.8956657437530543 1.0796830581390728 1.0212472007988296 1.1320911497592212 1.1403259119977527 1.4102768296482344 1.077451429092237 0.9381410245075481 0.7636713044776842 1.0 12.638597429254066 -7.799182682913373 3.809020099817982 0.8762423901441421 1.1189960154535696 0.34344920689315805 0.13259933697874546 0.24976169495762746 7.55920753199553 0.08101971898868528 0.037976932642661214 1.5878786781217667e-08 7.799182682913373 0.24275362530942757 RLSSSSATLLNS(ph)PDR ddPTM_A459_Selumetinib_30min_R1 1 RLSSSSATLLNSPDR 15 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 RLSSSSATLLNS(1)PDR 176.29 3.457e-05 10173000.0 792.69 1164.6 1318.9 1523.1 1108.6 931.14 741.98 947.69 369.53 714.36 True False 811.1581346937616 1028.248090592149 1139.8006241991206 1257.1191771279794 1008.3273257392264 921.7735770074761 686.0118512284752 922.55418266904 627.0654205966455 806.0550644556512 1.0063309201357808 1.2756548974561066 1.4140480898396885 1.5595946636436593 1.2509409967173577 1.143561547659244 0.851073185293806 1.1445299748746862 0.7779436520507668 1.0 9.654734587465413 -6.935624630213589 2.6946196742929076 0.9560071750074186 1.3230980754567114 0.5259073930612497 0.15909389818185068 0.22874053077242856 3.369212774055346 0.06518542060663043 0.05452746340109518 1.1597793445703818e-07 6.935624630213589 0.3670909004492928 RLSSSSATLLNS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 5 RLSSSSATLLNSPDR 15 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 RLSSSSATLLNS(1)PDR;RLSSSSATLLNS(1)PDR;RLSSSSATLLNS(1)PDR;RLSSSSATLLNS(1)PDR;RLSSSSATLLNS(1)PDR 195.38 1.2159000000000003e-05 69885900.0 117863.0 129791.0 144237.0 139226.0 146114.0 90365.0 81165.0 81576.6 67909.0 120648.0 True False 111312.64630297199 139745.55235615736 134956.94845337182 120263.17862175376 127757.85304426671 102811.95849820365 84939.33332539645 81813.97440026695 81492.69753599548 117164.57875885046 0.9500537404916294 1.1927286713826994 1.1518579239818019 1.0264465583005327 1.090413624984898 0.8775003468395721 0.7249574421312059 0.6982824951614212 0.6955403962465886 1.0 16.83817695398566 -6.903926651284318 2.801197101244747 0.7557731646267648 1.0919607157454776 0.6568962274452135 0.10327917885853878 0.14791993057002759 2.347401800973143 0.03891875977668923 0.03328259810238487 1.247594204705901e-07 6.903926651284318 0.3361875511187128 RLT(ph)VNEAVK ddPTM_A459_Selumetinib_30min_R2 2 RLTVNEAVK 9 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 RLT(1)VNEAVK;RLT(1)VNEAVK 120.03 0.008371700000000001 12446600.0 87184.0 65334.0 72779.0 85727.0 79395.0 80178.0 72354.0 72330.0 70474.0 71744.0 True False 82338.6623052044 70344.90771807905 68096.47837578368 74050.83471267641 69420.6902996944 91221.79171658243 75718.6043667311 72540.46832512389 84570.76920808372 69672.56430670185 1.181794629271083 1.0096500454385102 0.977378671983707 1.0628406669044246 0.9963848896690712 1.3092928705052376 1.0867779178245012 1.0411626017638362 1.213831729169595 1.0 16.088303042374562 RLTLEDLEDSWDR ddPTM_A459_Selumetinib_30min_R1 2 RLTLEDLEDSWDR 13 1 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 ; 138.31 0.0013460999999999998 7908700.0 1973.79 2566.6 2878.34 3122.4700000000003 2397.07 2515.8199999999997 2183.54 2152.04 1285.76 1663.83 False True 2019.7754666732276 2266.1012788200323 2487.4772375898838 2577.1892305211736 2180.2554417370825 2490.513134981795 2018.8338198218598 2094.9609083889054 2181.840811805112 1877.398787576636 1.075837206265789 1.2070431140232796 1.3249594353902523 1.3727446973841042 1.1613171672233669 1.3265765118537083 1.0753356362969582 1.1158848733960782 1.162161617575908 1.0 10.874519417383153 -7.274860088524741 24.863162282926673 1.098002593041831 1.2487044921235626 0.41804607340572186 0.0900414446220632 807.4992425460648 1495964.1651130132 0.0385710747969856 0.02616690426028234 5.3105550049489384e-08 7.274860088524741 0.1507018990817317 RLTTGTPAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 RLTTGTPASPR 11 1 A0A5E8;Q99501 A0A5E8 GAS2L1 GAS2-like protein 1 1 RLTTGT(0.003)PAS(0.997)PR 65.495 0.041245 1629200.0 12224.0 14220.0 13056.0 15678.0 17354.0 10477.0 13003.0 11998.0 10948.0 17745.0 True False 11544.639016549125 15310.628275493387 12215.991174297984 13542.629353941475 15173.835373271582 11920.111649263305 13607.665264955687 12032.912193624174 13137.905912678443 17232.655742953026 0.6699280243714083 0.8884659743611709 0.7088861610488265 0.7858701268073252 0.8805279696646084 0.6917164612969079 0.7896441191613944 0.6982622047994436 0.7623842841548637 1.0 14.07285743351744 -11.055538608462662 2.76253335078128 1.0119129439346486 0.7667773219140716 0.4919259337076004 0.07191223128534699 17821976.01574229 18402533.69871784 1588822.0373704925 0.018032491927724117 8.799568806851924e-12 11.055538608462662 -0.24513562202057704 RMEDEGGFPVPQENGQPES(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 RMEDEGGFPVPQENGQPESPR 21 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR 204.89 1.5278e-17 49434500.0 6837.9 6574.200000000001 6728.8 7726.300000000001 7575.599999999999 5693.9 6851.200000000001 6900.299999999999 3928.55 5714.85 True False 6997.209765762746 5804.489607737335 5815.065918652698 6377.0467456134875 6890.388317580809 5636.6245356475565 6334.408468067239 6717.281628666731 6666.462420060484 6448.406664852986 1.0851067758956656 0.900143230633186 0.9017833739220715 0.9889337129389737 1.0685412188931636 0.8741112074041415 0.9823214938649738 1.0416963410944982 1.0338154472167536 1.0 12.6547270140842 -7.643495728213844 5.56938656666954 1.0276909518108859 0.965806315278021 0.12203047016665458 0.06572213809824513 0.41291346451225885 18.40089708664192 0.03205410807635204 0.01808394909040062 2.272501987833895e-08 7.643495728213844 -0.06188463653286491 RMEDEGGFPVPQENGQPES(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 RMEDEGGFPVPQENGQPESPR 21 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR;RMEDEGGFPVPQENGQPES(1)PR 158.47 7.2245e-08 91878800.0 131851.3 115112.7 148039.7 173849.9 176513.0 116559.7 116389.2 135794.4 124229.40000000001 157034.9 True False 124523.53258857374 123941.47394433088 138514.9868754386 150171.24371219476 154337.8588937586 132614.74065139223 121801.52842082459 136189.53922202688 149078.7512594534 152500.89441133005 0.8165429656609428 0.81272621005115 0.9082896687925761 0.9847236915683151 1.012045598089896 0.8695997565345401 0.7986938626884234 0.8930409211548118 0.9775598486481899 1.0 17.21845817848287 RMEDEGGFPVPQENGQPES(ph)PRR ddPTM_A459_Selumetinib_30min_R2 1 RMEDEGGFPVPQENGQPESPRR 22 2 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RMEDEGGFPVPQENGQPES(1)PRR 87.792 0.00059089 2428200.0 6627.1 5359.3 6105.7 4347.8 6773.2 3936.6 4910.6 5541.0 5169.0 4459.0 True False 6258.792312383245 5770.34107713444 5712.865909383516 3755.622139626659 5922.29006282373 4478.830917103171 5138.9526301693 5557.123392638072 6202.944433927188 4330.257084126656 1.4453627557878688 1.3325631631171906 1.3192902403704998 0.8672977300570847 1.3676532242237904 1.0343106263877817 1.1867546268804836 1.2833241271075375 1.4324656281182953 1.0 12.080236963883037 -5.539868334034131 24.99942126740941 1.1759249412540975 1.373204066921537 0.24090181406552502 0.1635048133189014 342.07732252382567 503349.64011012285 0.043748724631949135 0.07579631019207592 2.8849059935396414e-06 5.539868334034131 0.19727912566743955 RMEEEQHHWDDR ddPTM_A459_Selumetinib_30min_R1 2 RMEEEQHHWDDR 12 1 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 ; 80.87100000000002 0.012972999999999998 13281000.0 1951.6999999999998 2485.2 2771.9 2826.98 2141.83 2245.42 1944.52 1414.0 1411.4299999999998 1587.51 False True 1997.1708126528831 2194.2316286618657 2395.4912049568165 2333.3010119869055 1948.101854670799 2222.833113478237 1797.8432908579675 1376.49612668069 2395.0936232314657 1791.2823721568834 1.114939131706013 1.2249501601580497 1.3373051854869789 1.3025869333919573 1.0875459307541162 1.2409172043610988 1.0036626937232593 0.7684417309501297 1.3370832318008763 1.0 10.806777061851914 -7.263983195229664 23.82307623936018 1.008000369074557 1.2216873625142497 0.2846971845329924 0.14678162731658972 141.03663588362298 1320801.5414018661 0.058056642524391223 0.04124315454481925 5.445237224609485e-08 7.263983195229664 0.21368699343969277 RMEEEQHHWDDR ddPTM_A459_Selumetinib_30min_R2 1 RMEEEQHHWDDR 12 1 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 57.567 0.034617 4877700.0 2440.1 640.12 747.37 1943.3 1362.6 1319.7 1031.4 2347.9 3473.3 3018.4 False True 2304.489010494237 689.2151456897909 699.2850278749302 1678.6191876205176 1191.418006201443 1501.47669595617 1079.3621436803273 2354.7320002842303 4168.057052110527 2931.25094925497 0.786179365188765 0.23512662601097575 0.23856197916205912 0.5726630768502331 0.40645377240876057 0.5122306898826924 0.36822577198812223 0.8033198252380022 1.421937979472523 1.0 11.51730076949188 -7.996676911335132 3.7463482046253977 1.2023226962951894 0.43776278268433216 0.7412222897355047 0.18079344571445732 0.1040713120724459 3.1633002733133138 0.11898946299080117 0.04641680834360366 1.0076810434450185e-08 7.996676911335132 -0.7645599136108572 RMEELHNQEMQK ddPTM_A459_Selumetinib_30min_R2 2 RMEELHNQEMQK 12 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 ; 99.752 0.0075321 16512200.0 90962.0 95774.0 102941.0 104731.0 109229.0 78858.0 60493.0 72037.0 63994.0 93669.0 False True 85906.6961897368 103119.55783805215 96317.88813368615 90466.45712894804 95506.67650035047 89719.97369834935 63306.04436460547 72246.61574363273 76794.58814175594 90964.53258871034 0.9443977091396469 1.1336237861442096 1.058851020201254 0.9945245092170779 1.0499331308849473 0.9863181961700592 0.6959420618455684 0.7942284062546736 0.8442256114146951 1.0 16.473016522305727 -7.0846895457746655 5.955882564571447 0.8172828915026613 1.0387006304453157 0.566944454458428 0.08359911374431227 0.15233322268725547 8.52734204709086 0.03099745348749004 0.024052669218506066 8.228306379975302e-08 7.0846895457746655 0.22141773894265437 RMEELHNQEVQK ddPTM_A459_Selumetinib_30min_R1 2 RMEELHNQEVQK 12 1 Q15233-2;Q15233;H7C367;C9JYS8 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 0 ; 77.593 0.030741 24487400.0 4514.299999999999 4689.299999999999 5694.4 6853.4 5012.9 4614.4 5169.4 4688.3 2514.0 3675.7 False True 4619.474406701294 4140.274576003572 4921.131757100217 5656.582344251129 4559.484080099381 4567.983325539981 4779.467996092183 4563.951054255361 4266.074384704805 4147.511899349961 1.1137941297830403 0.9982550204744385 1.1865262539382964 1.3638495757270002 1.0993299575135609 1.1013791970689513 1.152369929750236 1.1004069825503497 1.0285864123436093 1.0 12.01803040498935 -8.199673308344948 1.606549544650837 0.9979269616047499 1.147654963628542 0.26205418789271884 0.08735310663531894 0.5725609873383257 2.713316601899836 0.08837880786421279 0.02712335505339032 6.3143215145044386e-09 8.199673308344948 0.1497280020237921 RMGESDDSILR ddPTM_A459_Selumetinib_30min_R1 2 RMGESDDSILR 11 1 Q8WVC2;P63220 Q8WVC2 RPS21 40S ribosomal protein S21 0 ; 169.65 0.00055326 22477000.0 3126.1 2547.9 5123.5 5674.2 4153.3 3654.3 3219.4 3122.9 2056.84 2388.7 False True 3198.932047668281 2249.5906835134265 4427.756841370988 4683.307487925667 3777.634748324671 3617.541059838929 2976.5580660461887 3040.07054739118 3490.307254350131 2695.3129129083563 1.186849969199494 0.8346306184857858 1.6427617068747877 1.7375746858542598 1.4015570252466323 1.3421599557193713 1.1043460118455624 1.1279100592854043 1.2949543771464895 1.0 11.396237057341246 -7.209842142012802 5.820359049231044 1.1425028119293223 1.3674402197330566 0.17419636428227392 0.24002218623540586 0.4484752110318258 35.659485973431856 0.10411736704611939 0.07934546066875917 6.168191634424905e-08 7.209842142012802 0.22493740780373428 RMMET(ph)FQQLITYK ddPTM_A459_Selumetinib_30min_R2 1 RMMETFQQLITYK 13 1 A0A0D9SG77;A0A1B0GVL3;Q05086-2;Q05086-3;Q05086 A0A0D9SG77 UBE3A Ubiquitin-protein ligase E3A 1 RMMET(0.999)FQQLIT(0.001)YK 45.33 0.042178 6692700.0 26207.0 38751.0 78138.0 94440.0 112350.0 75622.0 50761.0 66067.0 87118.0 75407.0 True False 24750.519854933176 41723.07709589623 73110.68615022191 81577.10908191305 98235.58857825649 86038.24407183254 53121.48708101327 66259.2440320193 104544.03428029957 73229.80397908461 0.3379842428910809 0.5697554114416705 0.9983733695518737 1.113987811645823 1.3414700468993999 1.1749074747818005 0.7254080196115978 0.9048125275733881 1.4276159241141588 1.0 16.160143313601047 -5.166240696042581 2.2564349557224053 1.0925782185950694 0.3398009373754062 0.6502566633658687 0.19020594233061058 0.22876246258126837 2.088744146187378 0.05571218614773864 0.24356829796443547 6.8196063103731935e-06 5.166240696042581 -0.7527772812196633 RMNS(ph)TGGQTPR ddPTM_A459_Selumetinib_30min_R1 4 RMNSTGGQTPR 11 1 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 RMNS(0.779)T(0.217)GGQT(0.003)PR;RMNS(0.499)T(0.499)GGQT(0.002)PR;RMNS(0.5)T(0.5)GGQTPR;RMNS(0.5)T(0.5)GGQTPR 129.54 0.004608 11199000.0 3081.2500000000005 2874.12 4327.709999999999 5123.69 4075.04 3670.39 3556.5699999999997 3372.82 2585.98 2129.39 True False 3153.03712993119 2537.61669425786 3740.0307524094155 4228.933725073112 3706.453351506745 3633.4692090474764 3288.295061489065 3283.361857136608 4388.219187493605 2402.717948515061 1.3122793426002601 1.0561442285916955 1.5565833495857668 1.7600624857722889 1.5426085919895112 1.512232932414331 1.3685730626523653 1.3665198860173358 1.8263563520660564 1.0 11.230451587245058 -5.2706172989613025 24.750076214386336 1.5124574000462132 1.1842117826704874 0.22802448665321695 0.22363200885867085 661.5434517973324 1783986.0579674751 0.05600361211908519 0.1192611749962503 5.3626901053100525e-06 5.2706172989613025 -0.3282456173757258 RMNS(ph)TGGQTPR ddPTM_A459_Selumetinib_30min_R2 1 RMNSTGGQTPR 11 1 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 RMNS(0.858)T(0.142)GGQTPR 93.106 0.012355 7448500.0 4374.2 4163.5 4530.8 4982.7 6508.2 2990.9 2383.6 4951.4 2878.4 6320.0 True False 4131.099475309979 4482.827062237462 4239.2932607620505 4304.047664363067 5690.581731953786 3402.86932631303 2494.4421230137978 4965.807754251605 3454.160429215711 6137.525178667973 0.6730888029051723 0.730396524941079 0.6907170459351345 0.70126761831015 0.927178555899434 0.5544367195657769 0.40642474782566457 0.8090895938824212 0.5627936877914963 1.0 12.583441322633599 -10.767074799693805 5.526539877231459 1.0000215524843294 0.6760497264091927 0.34234642571395035 0.13597536249047704 3.690471949986659e-05 5.04687971463449e-06 0.1345599252007098 0.0326334069845732 1.7097208199656383e-11 10.767074799693805 -0.32397182607513675 RMNSTGGQT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 RMNSTGGQTPR 11 1 Q96ST2;Q96ST2-3;Q96ST2-2;A0A1B0GW95 Q96ST2 IWS1 Protein IWS1 homolog 1 RMNSTGGQT(1)PR 96.464 0.025217 1539600.0 5552.7 4689.8 4607.4 6143.6 6328.2 2749.8 5214.5 7703.3 5104.4 7699.2 True False 5244.103163219268 5049.492579916237 4310.9649001578255 5306.83108169887 5533.194941174203 3128.55998980092 5456.984582335725 7725.715327650037 6125.422628852378 7476.904091076019 0.7013736032107611 0.6753453726847997 0.5765708437136612 0.7097631609361932 0.7400382395941512 0.4184298677222542 0.7298454702460142 1.033277307498298 0.8192458475110457 1.0 12.868225311857847 -7.607165947010984 5.513487853796902 0.9409179335848649 0.6385628111430586 0.6615016851712192 0.10021531807617884 0.12510222698353923 6.240280368825514 0.047497021585446754 0.0269147737839272 2.470779862057279e-08 7.607165947010984 -0.3023551224418063 RMS(ph)ADMSEIEAR ddPTM_A459_Selumetinib_30min_R1 4 RMSADMSEIEAR 12 1 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 RMS(0.994)ADMS(0.006)EIEAR;RMS(1)ADMSEIEAR;RMS(1)ADMSEIEAR;RMS(1)ADMSEIEAR 192.4 0.00014241 53280800.0 7428.5 8742.5 9147.199999999999 9693.900000000001 9189.6 8152.5 7990.400000000001 6654.200000000001 4777.93 5879.5 True False 7601.569596655202 7718.92403572202 7905.060481973005 8001.042342039862 8358.40230255566 8070.4932518777505 7387.677694892057 6477.709000112198 8107.79824379977 6634.1910961797985 1.1458170990932797 1.1635064356477234 1.1915635783426586 1.2060313346486424 1.259897730013946 1.216499967347191 1.1135762578720625 0.9764127843471816 1.2221231083422555 1.0 12.695704853848657 -7.417214606946717 4.55442889245624 1.0695020854189932 1.1980841330756873 0.43951165910378387 0.06726495921557389 0.21283918159183474 7.169449762998806 0.028723669497624834 0.01869157630156721 3.82635616912684e-08 7.417214606946717 0.12858204765669412 RMS(ph)ADMSEIEAR ddPTM_A459_Selumetinib_30min_R2 4 RMSADMSEIEAR 12 1 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 RMS(1)ADMSEIEAR;RMS(1)ADMSEIEAR;RMS(1)ADMSEIEAR;RMS(1)ADMSEIEAR 179.55 5.3333e-05 53428000.0 53711.5 54040.6 62244.0 66798.0 68378.0 55097.1 44622.8 49508.9 41255.5 64216.0 True False 50726.42985417037 58185.34025208351 58239.28880614305 57699.997167022695 59787.744332924 62686.22540332396 46697.84861840077 49652.962702360404 49507.7527749822 62361.917226794685 0.8134199862664747 0.9330268028880188 0.9338918910132499 0.9252441190539772 0.9587220372890547 1.0052004202396447 0.7488199640907829 0.7962064816221894 0.7938779783651437 1.0 15.928377661835798 -7.263393103428516 24.999778397471328 0.8177433148639703 0.9299727548555491 0.2510911255476238 0.07688864938538532 208.91043231385075 2673181.123657312 0.030033991301687952 0.021400581458617316 5.452640896320367e-08 7.263393103428516 0.11222943999157875 RMS(ph)GEPIQTVESIR ddPTM_A459_Selumetinib_30min_R1 1 RMSGEPIQTVESIR 14 1 Q5VT52-2;Q5VT52-3;Q5VT52 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 RMS(1)GEPIQTVESIR 88.486 0.010641 5004800.0 571.12 835.37 833.1 956.18 780.82 852.39 694.27 756.16 413.13 625.84 True False 584.4259847939314 737.5644920470227 719.9695958907334 789.2011127215753 710.1949688649676 843.8157305081966 641.9006549400162 736.1041804461602 701.051436178638 706.1726601978341 0.8275964473478832 1.044453479465481 1.0195376236868674 1.1175752860504127 1.005695928055338 1.1949141875186753 0.9089854239899176 1.0423855551699506 0.9927479151943359 1.0 9.463877157345587 -4.760645781934508 24.930878024264256 1.0396243942395764 0.8275961945326576 0.4262297445901423 0.07253334704519657 17.472667394583855 548551.0052271585 0.01723774978576823 0.1007816805638803 1.7352186950280732e-05 4.760645781934508 -0.21202819970691877 RMS(ph)GEPIQTVESIR ddPTM_A459_Selumetinib_30min_R2 1 RMSGEPIQTVESIR 14 1 Q5VT52-2;Q5VT52-3;Q5VT52 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 RMS(1)GEPIQTVESIR 105.02 0.0030667 4760600.0 8745.3 8528.4 7796.8 10471.0 9623.9 6957.1 6400.7 7681.2 7292.8 8968.3 True False 8259.271236209677 9182.500856871855 7295.162376513978 9044.831736517486 8414.859643242382 7915.377374734153 6698.345232746436 7703.55102030889 8751.563777857265 8709.361876558218 0.9483210542026062 1.054325332558189 0.8376230635391734 1.0385183053263876 0.966185555556199 0.9088355136601772 0.7690971310740277 0.8845138288539222 1.0048455790329067 1.0 13.088351302998245 -6.784095697560196 5.326635600286926 0.8964768276037564 0.9705975134802877 0.08483074448518813 0.08288085517963455 0.3585145980239032 27.966280225759608 0.02908129985013343 0.0265668582236397 1.6440094229042925e-07 6.784095697560196 0.07412068587653131 RMS(ph)PKPELTEEQK ddPTM_A459_Selumetinib_30min_R1 1 RMSPKPELTEEQK 13 2 P41208 P41208 CETN2 Centrin-2 1 RMS(1)PKPELTEEQK 73.273 0.020487 13688000.0 2638.3 3701.6 1980.2 1873.6 2190.5 2453.4 2330.3 2345.3 1714.3 3002.7 True False 2699.7672567618515 3268.214951172845 1711.2997164600038 1546.4109318278386 1992.3696617641867 2428.721023508968 2154.523594864707 2283.0950253919536 2909.041892481878 3388.1257937748255 0.7968320602860348 0.9646085033730746 0.5050874201909094 0.45642075470430804 0.588044772547958 0.7168331907780341 0.6359042509057137 0.6738519064394832 0.8585991399217844 1.0 11.72627172446976 -8.444327308455119 2.4256212894621014 0.9982855288081158 0.660947709204739 0.3908167213389939 0.13644953973045465 0.30801470610948095 3.853380859057618 0.14427446490579257 0.039601266275337034 3.594783102082131e-09 8.444327308455119 -0.33733781960337683 RMSLT(ph)AIY(ph)DK ddPTM_A459_Selumetinib_30min_R2 1 RMSLTAIYDK 10 1 Q68DQ2;Q68DQ2-1 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 2 RMS(0.007)LT(0.993)AIY(1)DK 61.679 0.033719 13797000.0 6029.9 5542.9 14693.0 18558.0 35714.0 21689.0 9683.7 18793.0 31908.0 18307.0 True False 5694.782297602224 5968.02260676739 13747.668376528822 16030.368385664373 31227.288032789045 24676.462876860925 10134.011237887526 18847.684518651356 38290.491584010204 17778.42934270167 0.320319764351963 0.3356889684530742 0.7732780051333645 0.9016751748233088 1.756470576272158 1.3880001658859142 0.5700172406989202 1.0601433993598897 2.1537612151170746 1.0 14.117840252671707 -5.6465198996567105 1.8176318818655743 1.2854953745103899 0.32221256188558345 0.46674988550404284 0.4130910089828054 0.33976219791344586 2.250713816547082 0.1312238596841043 0.3090131663087074 2.2567325881675435e-06 5.6465198996567105 -0.9632828126248064 RNALFPEVFS(ph)PTPDENSDQNSR ddPTM_A459_Selumetinib_30min_R1 3 RNALFPEVFSPTPDENSDQNSR 22 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 RNALFPEVFS(0.991)PT(0.009)PDENSDQNSR;RNALFPEVFS(0.987)PT(0.013)PDENSDQNSR;RNALFPEVFS(0.995)PT(0.004)PDENSDQNSR 124.86 1.6417e-05 55307000.0 3356.14 3182.96 3919.68 4307.6 3647.7400000000002 3044.96 3010.59 3469.8399999999997 2080.33 2584.18 True False 3434.331532088358 2810.2975634820423 3387.40898526106 3555.3585236665235 3317.8025610608047 3014.330467002476 2783.4987724600865 3377.8085715712336 3530.168068708413 2915.8846750448 1.1778008785740446 0.9637889960236046 1.1617088337723835 1.2193069753733996 1.1378373738357226 1.0337618949062735 0.9545983749913979 1.1584163806201755 1.2106679317329911 1.0 11.509717946017231 -6.7383387821566245 24.63088681613736 1.0740842685389096 1.1292296840021687 0.09561657066245555 0.09280676051411871 612.4524257578539 653022.0419258456 0.032615273589765466 0.03259309554186803 1.8266747174053985e-07 6.7383387821566245 0.05514541546325913 RNALFPEVFS(ph)PTPDENSDQNSR ddPTM_A459_Selumetinib_30min_R2 3 RNALFPEVFSPTPDENSDQNSR 22 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 RNALFPEVFS(0.972)PT(0.028)PDENSDQNSR;RNALFPEVFS(0.989)PT(0.01)PDENSDQNSR;RNALFPEVFS(0.981)PT(0.018)PDENSDQNSR 121.44 1.6758e-05 12461200.0 55156.7 49887.8 55452.4 61636.7 58014.2 40762.4 37415.2 42432.7 33319.1 57618.3 True False 52091.311423764346 53714.03384544018 51884.65295600807 53241.67513076188 50725.93754247158 46377.050595774635 39155.0809368123 42556.17213188838 39983.851013438434 55954.70996867796 0.9309549000061612 0.9599555403916479 0.927261583252809 0.9515137360298218 0.9065534888996241 0.8288319360735734 0.6997638082429581 0.7605467378118884 0.7145752526609536 1.0 15.77197195422674 -6.803561695728618 2.7594391542180747 0.772906807737898 0.9409025467933712 0.4195184686598551 0.07871464985870968 0.21859291099705333 3.402648793507749 0.02787481523229066 0.025231020793961407 1.57194846612796e-07 6.803561695728618 0.16799573905547316 RNDDIS(ph)ELEDLSELEDLKDAK ddPTM_A459_Selumetinib_30min_R1 1 RNDDISELEDLSELEDLKDAK 21 2 D6RAY8;Q9H4L7;Q9H4L7-2 D6RAY8 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 1 RNDDIS(1)ELEDLSELEDLKDAK 91.481 0.004169399999999999 0.0 305.88 278.98 343.28 342.61 292.26 211.91 284.85 283.09 66.066 171.28 True False 313.0064088611285 246.31689190571663 296.66446150206536 282.7795950862168 265.8251346026939 209.7783777988855 263.36353516594943 275.5815335940853 112.10917673027352 193.26545640848298 1.619567276417793 1.2745003503632069 1.5350102755819943 1.4631667776601425 1.3754404927947903 1.085441659866526 1.3627036101542545 1.425922349059732 0.5800787104619526 1.0 7.594439988101653 -8.251312757015054 24.95224019231681 0.7900393527287703 1.3840507367683772 0.6776724192466597 0.16617307840479162 335.51743375756257 826728.1785264426 0.1136371795056334 0.04184212110880091 5.606440829833483e-09 8.251312757015054 0.5940113840396068 RNDDISELEDLS(ph)ELEDLKDAK ddPTM_A459_Selumetinib_30min_R1 2 RNDDISELEDLSELEDLKDAK 21 2 D6RAY8;Q9H4L7;Q9H4L7-2 D6RAY8 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 1 RNDDISELEDLS(1)ELEDLKDAK;RNDDISELEDLS(1)ELEDLKDAK 62.916 0.0054354 6868800.0 2495.3 2680.5699999999997 3483.0 3719.1 2308.43 2605.79 2349.4900000000002 2739.2200000000003 1721.5700000000002 2428.34 True False 2553.435634991414 2366.7276182368155 3010.0277307495166 3069.6290011533497 2099.632914086417 2579.578118468018 2172.2660777147494 2666.566987359461 2921.3785515020886 2740.0410930346543 0.9318968396066751 0.8637562495880724 1.098533791482611 1.1202857537270252 0.7662778924826373 0.9414377488810141 0.7927859488081319 0.9731850351215648 1.0661805616450077 1.0 11.419981814443785 -8.005273616712039 24.840941227129292 1.0286211501672233 0.9321851882619666 0.12424070809014665 0.10817076849757537 468.8770512878233 2208593.7405675394 0.06534370599649496 0.02992111348279297 9.879304768930802e-09 8.005273616712039 -0.09643596190525672 RNDFQLIGIQDGYLSLLQDSGEVR ddPTM_A459_Selumetinib_30min_R1 3 RNDFQLIGIQDGYLSLLQDSGEVR 24 1 P63241;P63241-2;I3L397;I3L504 P63241 EIF5A Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A 0 ;; 183.75 4.4194e-21 20163900.0 2383.9 2484.74 2389.27 2487.08 2886.37 2272.12 2182.12 2299.52 1507.1799999999998 1843.6399999999999 False True 2439.4402317380814 2193.825485675712 2064.8202573206718 2052.758166273687 2625.2983431300136 2249.2645357198985 2017.520931565109 2238.5292597063503 2557.5743799281577 2080.2891525743557 1.1726447877302424 1.0545771884455848 0.9925640648394761 0.9867657886565436 1.2619872289778609 1.081226873166375 0.9698271651652026 1.0760664001618105 1.2294321569495097 1.0 11.022568356293817 RNEIDAEPPAKR ddPTM_A459_Selumetinib_30min_R2 1 RNEIDAEPPAKR 12 2 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 103.08 0.0069899 2827500.0 11969.0 8657.8 11642.0 10789.0 13517.0 8409.9 10949.0 9199.2 8455.4 11476.0 False True 11303.810895703256 9321.825420785271 10892.966394851192 9319.519587936891 11818.873616486797 9568.287387528817 11458.150195031909 9225.96814899046 10146.716263615393 11144.658061771139 1.0142806385848706 0.8364388901945209 0.9774159363593836 0.8362319899167735 1.0604967466008113 0.858553697609651 1.0281293631014237 0.8278377046522183 0.9104555929285146 1.0 13.444064732337797 -4.395523333819366 11.485999750503048 0.9248743251564941 3.6095459071486404 0.0940403427767682 0.081951392350923 203467.7062661253 320468.8418039945 0.0186238272082877 13721777.125079807 4.02232044252748e-05 4.395523333819366 2.6846715819921463 RNES(ph)LTATDGLR ddPTM_A459_Selumetinib_30min_R2 2 RNESLTATDGLR 12 1 H0Y507;Q5TCZ1-2;Q5TCZ1-3;Q5TCZ1 H0Y507 SH3PXD2A SH3 and PX domain-containing protein 2A 1 RNES(0.934)LT(0.064)AT(0.001)DGLR;RNES(0.934)LT(0.065)AT(0.001)DGLR 72.523 0.029251 5751900.0 20262.0 16270.199999999999 20622.0 21964.2 22304.0 14750.2 16191.0 15638.4 16559.0 18371.3 True False 19135.919155212574 17518.072023061348 19295.20297153594 18972.63806964163 19501.972119710103 16781.90616101591 16943.913581857854 15683.90515492352 19871.262697117487 17840.872834630205 1.0725887310887956 0.981906669333897 1.081516759319241 1.0634366516426597 1.0931063911769834 0.940643785568676 0.949724474744795 0.8790996550617254 1.1138055229308161 1.0 14.122898577957278 -6.76559746299794 24.99860298071619 0.9674152723957783 1.0558069845791564 0.29367251286741547 0.06258956852133361 128.21061402662562 770801.3892738236 0.02116524718735832 0.019334000155644245 1.7155466693447913e-07 6.76559746299794 0.08839171218337816 RNEVLDR ddPTM_A459_Selumetinib_30min_R2 1 RNEVLDR 7 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 102.51 0.026018 17374000.0 33319.0 31626.0 32618.0 38961.0 30995.0 23797.0 30693.0 29208.0 26668.0 37407.0 False True 31467.263366524894 34051.61250638211 30519.39339179318 33654.444588526196 27101.1310011843 27074.82074234218 32120.285317025715 29292.990444355313 32002.345166177252 36326.96271494189 0.8662233507780126 0.9373646999774112 0.8401306112839443 0.926431555883519 0.7460334962173194 0.7453092336620218 0.8841995839033937 0.8063704822838551 0.8809529554479971 1.0 15.148753127101097 -6.761707087581866 0.005806984685623675 1.709943151753146 2.5181416447391154e-07 0.06092153102235165 0.07529175210378206 43844.81407695497 99.79062747715457 14458.61078689208 14921.689005777609 1.7309834373624274e-07 6.761707087581866 -1.7099428999389816 RNGS(ph)PTPAGSLGGGAVATAGGPGSR ddPTM_A459_Selumetinib_30min_R1 2 RNGSPTPAGSLGGGAVATAGGPGSR 25 1 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 RNGS(0.985)PT(0.015)PAGSLGGGAVATAGGPGSR;RNGS(0.935)PT(0.063)PAGS(0.002)LGGGAVATAGGPGSR 67.31 0.00093187 11395700.0 1158.81 1338.29 1766.5500000000002 1769.94 1499.82 1552.68 1408.81 1197.6799999999998 825.28 953.7 True False 1185.808018348255 1181.6023846458588 1526.6622129645602 1460.8532048886452 1364.1615458147276 1537.0614489206428 1302.5423274605623 1165.9136357870777 1400.4398839336434 1076.116684824675 1.10193256462839 1.0980244069335008 1.4186772071220972 1.357523050696545 1.2676706578868646 1.428340876594685 1.210409935863765 1.0834453663145578 1.3013829296418802 1.0 10.07161880446264 -10.937622125124602 8.922631466851021 0.9999984712860174 1.254891543778202 0.27666290302531527 0.12212475123196621 3.960626508331265e-06 2.5966333658647673e-07 0.12610078780247658 0.030583750211594617 1.1544573016167185e-11 10.937622125124602 0.2548930724921846 RNHLFT(ph)MMK ddPTM_A459_Selumetinib_30min_R1 1 RNHLFTMMK 9 1 O43149-3 O43149-3 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 1 RNHLFT(1)MMK 89.679 0.044209 3746900.0 1459.8 1677.4 2011.0 2045.0 1880.3 1641.9 1890.4 1486.1 1039.3 1368.6 True False 1493.8104997236674 1481.0092281978968 1737.9172456322938 1687.8791394043183 1710.227196993928 1625.3839767259215 1747.805606030228 1446.6838004668837 1763.6161925313052 1544.2731412929106 0.9673227227619886 0.959033210250586 1.1253949830256444 1.0929926152773572 1.107464185747656 1.0525236328109044 1.1317982287556423 0.9368056477726976 1.1420364347299041 1.0 10.5927122346368 -5.245346818671105 24.082045476281767 1.0745939809573517 0.9631779236663418 0.34592084578513127 0.060738670528115324 530.8743118667477 794432.2369717174 0.014650360383722433 0.0384563219733986 5.683988378923779e-06 5.245346818671105 -0.1114160572910099 RNHS(ph)YHLRYHGSS(ph)Y(ph)S(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RNHSYHLRYHGSSYSR 16 2 Q14236 Q14236 DIAPH2-AS1 Early lymphoid activation gene protein 4 RNHS(0.826)Y(0.141)HLRY(0.099)HGS(0.204)S(0.83)Y(0.948)S(0.951)R 42.556 0.047968 0.0 6205.6 6633.2 7163.1 8048.7 7458.6 5440.7 5735.8 6508.0 6094.7 5856.2 True False 5860.717594985053 7141.94511090033 6702.233944593592 6952.453175218064 6521.583987269986 6190.1070392428055 6002.526065272078 6526.9372025426 7313.810300146265 5687.116289765088 1.0305253658224625 1.2558113368902704 1.1784942672361698 1.222491825554923 1.1467294943496515 1.0884439008892666 1.0554604054913774 1.1476707825174788 1.2860314309571412 1.0 12.47348158938341 -6.51877667293557 22.724635751431435 1.1206179911994145 1.1790934648174793 0.07975479126209273 0.08818431329956893 142.1030317875247 787241.8877119535 0.028486816212646253 0.029231396677938344 3.0284703567651736e-07 6.51877667293557 0.05847547361806482 RNIS(ph)PESSDNSH ddPTM_A459_Selumetinib_30min_R1 1 RNISPESSDNSH 12 1 A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-8 A0A3B3ISF0 LARP1B La-related protein 1B 1 RNIS(0.976)PES(0.024)SDNSH 201.08 0.00015234 1241300.0 443.05 594.61 537.98 865.85 588.01 463.54 735.63 614.69 208.8 346.43 True False 453.37220297477097 524.9927847733107 464.92527091261155 714.6455515174717 534.8245993215974 458.87720846064525 680.1408368408895 598.3864244054828 354.31834985137783 390.8976650139585 1.1598232569605695 1.3430440541377087 1.1893784806721974 1.828216475767264 1.3681959427987358 1.1739062407657495 1.7399460209530861 1.5308007132355603 0.9064222725370477 1.0 8.610647156640752 -8.266121137535656 24.94998830462143 0.9532110620423002 1.4214206951842074 0.4192467133880975 0.21812831111478106 400.11764809950716 2132262.5802524374 0.19153368251217118 0.05584826064562347 5.418497314553668e-09 8.266121137535656 0.4682096331419072 RNIS(ph)PESSDNSH ddPTM_A459_Selumetinib_30min_R2 1 RNISPESSDNSH 12 1 A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-8 A0A3B3ISF0 LARP1B La-related protein 1B 1 RNIS(0.806)PES(0.153)S(0.04)DNSH 177.21 4.2651e-08 0.0 8527.1 6027.0 7547.1 6949.3 7914.1 7053.0 6025.1 6351.8 6152.7 7253.5 True False 8053.197918685875 6489.251520140547 7061.52780266118 6002.793351788841 6919.860005048322 8024.486729240635 6305.279088509158 6370.282686402901 7383.411920801668 7044.072608143692 1.1432587888681793 0.9212357511247522 1.0024779975290583 0.8521765299308497 0.9823663653109186 1.1391828528234478 0.8951184122122179 0.9043465393923086 1.04817373862184 1.0 12.782194064766609 -4.751558794365221 24.791092208453165 0.9690907274301914 1.1432591811193082 0.2954106612293603 0.07940689042505779 477.85349992438796 1198876.7220943328 0.019894238468983298 0.25760750113582664 1.771908149692455e-05 4.751558794365221 0.17416845368911682 RNISPES(ph)SDNSH ddPTM_A459_Selumetinib_30min_R2 1 RNISPESSDNSH 12 1 A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-8 A0A3B3ISF0 LARP1B La-related protein 1B 1 RNIS(0.035)PES(0.941)S(0.024)DNSH 171.36 3.6837e-06 0.0 4190.5 5052.2 6656.7 5267.6 6383.4 3170.7 4327.3 4441.3 5457.5 4672.6 True False 3957.6087859006166 5439.687494616576 6228.415169266956 4550.1437928831565 5581.460223679947 3607.4351442511374 4528.528024382281 4454.223447703205 6549.1524952907 4537.689897127212 0.8721637828107554 1.1987790302859642 1.3725960368534953 1.0027445453608077 1.2300224013133954 0.7949937580650863 0.9979809389904031 0.9816059600113156 1.4432789908003485 1.0 12.147742304169615 RNLEVLR ddPTM_A459_Selumetinib_30min_R1 3 RNLEVLR 7 1 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 0 ;; 152.47 0.0027849 54303700.0 11845.5 15368.400000000001 15077.8 15544.9 13682.800000000001 13691.9 13951.600000000002 10915.3 6727.8 9817.2 False True 12121.477102669336 13569.060583424678 13030.317576426945 12830.275028912562 12445.193155894542 13554.171917250535 12899.219579502396 10625.790786108715 11416.585220929584 11077.33324762588 1.0942594965505112 1.2249392773601742 1.1763045568047377 1.1582458288561803 1.1234827803489458 1.2235952114337172 1.1644697592055369 0.9592372594176545 1.030625780205395 1.0 13.435322988961083 -7.7528658988277845 24.96411558458017 0.9961986371210348 1.1693253496903369 0.785423652278236 0.04066376739151588 72.57403139922042 211321.3551045814 0.01875814269528439 0.010607523901391042 1.7665832209141752e-08 7.7528658988277845 0.173126712569302 RNLEVLR ddPTM_A459_Selumetinib_30min_R2 5 RNLEVLR 7 1 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 0 ;;;; 152.47 0.0012874 68399600.0 158495.0 131718.2 152605.7 146189.8 169931.8 122375.1 124855.4 125557.9 112225.2 141006.0 False True 149686.48240575532 141820.56239923323 142787.215406523 126278.4970485286 148583.44807443285 139231.15921444714 130661.42349628171 125923.25270177067 134673.37583408126 136934.7904024138 1.0931223684344042 1.0356795521610065 1.0427387735936975 0.9221797957803909 1.0850671888260597 1.0167697982761352 0.9541871945931608 0.9195855365295902 0.9834854636890532 1.0 17.063129506602188 -7.200259731155381 4.74992785678899 0.9575036108923078 1.031416206578453 0.32837453525088267 0.047718836691836866 0.25246095494282256 11.717415807099092 0.018996977085422057 0.014339778590405779 6.305801113068111e-08 7.200259731155381 0.07391259568614506 RNLLEDDS(ph)DEEEDFFLR ddPTM_A459_Selumetinib_30min_R1 1 RNLLEDDSDEEEDFFLR 17 1 O75379 O75379 VAMP4 Vesicle-associated membrane protein 4 1 RNLLEDDS(1)DEEEDFFLR 74.214 0.012037 2220100.0 358.0 267.2 587.64 722.81 457.38 406.39 416.68 476.95 274.3 431.36 True False 366.3407034532626 235.91609978209013 507.8417156754653 596.5848023241246 416.0100597569978 402.3020855725971 385.2494921290075 464.2997366480589 465.4670659206554 486.729257802214 0.7526580693082721 0.48469677135775624 1.0433761840588398 1.225701543026105 0.8547052659941937 0.826541817907473 0.7915067482661098 0.953917869545312 0.9563161828866292 1.0 8.926975688898002 -5.265748171504498 24.995309715720566 0.9503060778528328 0.6186774137388948 0.513666252634597 0.13137707771341361 286.3751811047918 1661272.2275074758 0.03697758852183862 0.08154246248677825 5.423152642995366e-06 5.265748171504498 -0.331628664113938 RNNQTVLEQSIET(ph)T(ph)NHVVS(ph)IT(ph) ddPTM_A459_Selumetinib_30min_R1 1 RNNQTVLEQSIETTNHVVSIT 21 1 H0YKA3 H0YKA3 ZHX2 4 RNNQTVLEQS(0.002)IET(0.999)T(0.999)NHVVS(1)IT(1) 81.726 0.0013437999999999998 10936000.0 1577.3 1628.1 1645.5 2199.8 1828.4 1268.1 1520.5 1586.1 819.34 1222.7 True False 1614.0480211084664 1437.4812951168442 1422.0501380845053 1815.6462253602058 1663.0215428302376 1255.3440653426765 1405.8074608384275 1544.0314756211037 1390.360137774079 1379.6454551065642 1.1699005821635509 1.0419207991416988 1.0307359277131571 1.3160237788917768 1.2053977611963977 0.9099033818407449 1.018962847038004 1.1191509165677949 1.0077662580830864 1.0 10.430081851754498 -6.746460595633783 24.982415542464192 1.019091474922201 1.1489231696326905 0.3852891414546352 0.08910472525684811 305.72982028601933 509911.6431100022 0.03203937871303961 0.031915506896483856 1.7928312119796552e-07 6.746460595633783 0.1298316947104894 RNPNPS(ph)SSSIFGR ddPTM_A459_Selumetinib_30min_R1 1 RNPNPSSSSIFGR 13 1 Q9ULJ8-3 Q9ULJ8-3 PPP1R9A Neurabin-1 1 RNPNPS(0.661)S(0.117)S(0.221)S(0.002)IFGR 81.327 0.018112 49556000.0 4160.7 5456.2 4008.8 5161.9 3973.2 4008.8 4579.8 3338.8 2175.8 3432.8 True False 4257.63621468712 4817.385567481435 3464.4269787621774 4260.471065863646 3613.824761525432 3968.4751116991733 4234.341998781865 3250.244178049141 3692.173685855497 3873.4333183036 1.0991892372505807 1.2436991091900986 0.8944072852348598 1.0999211076465754 0.9329771457400833 1.0245368347885224 1.0931753952682803 0.8391119482270086 0.9532044009660434 1.0 11.919397188351892 -5.258579135675181 24.997070390686826 0.9822044562499114 1.1714441768472401 0.4558947992969823 0.08376764323643773 212.23851304067182 1854832.1873169122 0.021173769168328527 0.0511201029295395 5.513417295983772e-06 5.258579135675181 0.18923972059732874 RNPNPS(ph)SSSIFGR ddPTM_A459_Selumetinib_30min_R2 1 RNPNPSSSSIFGR 13 1 Q9ULJ8-3 Q9ULJ8-3 PPP1R9A Neurabin-1 1 RNPNPS(0.356)S(0.356)S(0.222)S(0.065)IFGR 73.833 0.026008 5869900.0 11639.0 12875.0 14499.0 15985.0 16041.0 10534.0 9466.4 9935.0 11370.0 13966.0 True False 10992.150974608587 13862.471100350023 13566.15012531759 13807.815424336935 14025.786171640499 11984.962881868829 9906.606357315737 9963.909205172216 13644.317704343612 13562.765291974194 0.8104653245834184 1.0220976918735873 1.0002495680836856 1.0180678591044963 1.034139120577446 0.8836666139877069 0.7304267340804017 0.7346517462090411 1.0060129634785966 1.0 13.727363736953373 -6.927102118991975 5.981736038853599 0.8404317244184785 0.9822091028749294 0.18354988003078 0.10566780558196688 0.2694416585376358 16.688761480130836 0.037360576215727206 0.03282284690728311 1.182763410794312e-07 6.927102118991975 0.1417773784564509 RNQEIQQGEDAFPPS(ph)SPLFAEPYK ddPTM_A459_Selumetinib_30min_R2 1 RNQEIQQGEDAFPPSSPLFAEPYK 24 1 Q9UHB7;Q9UHB7-2;Q9UHB7-3;C9JCE0 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 RNQEIQQGEDAFPPS(0.5)S(0.5)PLFAEPYK 74.444 0.0054959 0.0 5110.0 3563.1 4963.7 3077.9 4609.6 4263.2 4615.8 4581.7 2587.8 4477.6 True False 4826.006656950755 3836.3783128277396 4644.340946067934 2658.684710326347 4030.500837653144 4850.417102523557 4830.443846034186 4595.031988458731 3105.4323091732967 4348.3200537980565 1.1098554377880858 0.8822667755279054 1.068077070824471 0.611428017586725 0.9269098842282062 1.1154692024766995 1.1108758753429424 1.0567372989127566 0.714168292755002 1.0 12.086242417077424 -6.547974640803136 24.51760666173302 1.011208065141406 0.906472703630168 0.05246474383960176 0.16320325277520478 498.72151129606465 487225.168690123 0.05460679286429127 0.05460883831722764 2.831557330442967e-07 6.547974640803136 -0.10473536151123797 RNS(ph)CNVGGGGGGFK ddPTM_A459_Selumetinib_30min_R2 1 RNSCNVGGGGGGFK 14 1 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 RNS(1)CNVGGGGGGFK 78.166 0.019848 12890000.0 71290.0 50505.0 70047.0 71519.0 78187.0 68814.0 79027.0 81397.0 78133.0 77309.0 True False 67327.98719648135 54378.57110082937 65540.25228140719 61777.9888228435 68364.45005935138 78292.50386870328 82701.9120890297 81633.85179400125 93761.78321842372 75076.88829709525 0.8967871301491632 0.7243050735619432 0.8729750761918958 0.8228629372380862 0.9105924820541134 1.042830964955329 1.1015628639503625 1.0873366444139068 1.248876789450681 1.0 16.196081235746732 -6.747501992489393 1.501980931611772 1.122643637580946 0.8193261524635524 0.7672370303513012 0.07080186750962564 0.17030021517853555 0.7996155459753223 0.02991404090296104 0.027435073078987557 1.7885373235008187e-07 6.747501992489393 -0.30331748511739365 RNS(ph)EGSELSCTEGSLTSSLDSR ddPTM_A459_Selumetinib_30min_R1 4 RNSEGSELSCTEGSLTSSLDSR 22 1 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 RNS(0.96)EGS(0.04)ELSCTEGSLTSSLDSR;RNS(0.918)EGS(0.082)ELSCTEGSLTSSLDSR;RNS(0.997)EGS(0.003)ELSCTEGSLTSSLDSR;RNS(0.994)EGS(0.006)ELSCTEGSLTSSLDSR 150.59 1.1721e-07 38527200.0 2034.02 2327.8999999999996 2383.0 2553.12 2309.42 2309.72 2693.99 2761.57 1758.48 1944.56 True False 2081.408708486047 2055.3483857886517 2059.4016888820265 2107.2655199980213 2100.5333687612174 2286.486313857966 2490.7801653562083 2688.3241927564304 2984.0121257023484 2194.163217618401 0.9486116127428567 0.9367345005535083 0.9385818121212295 0.960395973771404 0.9573277648146832 1.0420766766566136 1.135184541129881 1.2252161421584689 1.3599772805148327 1.0 11.099455132413375 -7.200840160733596 1.700567442469211 1.2167397442575194 0.9459837637183812 0.6330159149836518 0.08322618581858603 0.2165491816088132 1.2277500398248393 0.042086364696695015 0.027126522522781794 6.297379111640578e-08 7.200840160733596 -0.2707559805391382 RNS(ph)EGSELSCTEGSLTSSLDSR ddPTM_A459_Selumetinib_30min_R2 4 RNSEGSELSCTEGSLTSSLDSR 22 1 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 RNS(0.829)EGS(0.171)ELSCTEGSLTSSLDSR;RNS(0.919)EGS(0.081)ELSCTEGSLTSSLDSR;RNS(0.966)EGS(0.034)ELSCTEGSLTSSLDSR;RNS(0.974)EGS(0.026)ELSCTEGSLTSSLDSR 137.4 7.0973e-06 51419500.0 30808.4 20990.2 31308.699999999997 34269.4 41891.0 19437.0 29147.8 34013.100000000006 32376.8 42150.2 True False 29096.192463796808 22600.080845869288 29294.33232833513 29601.848601987633 36628.27806970841 22114.270318481522 30503.230455269993 34112.07248982818 38853.06468337664 40933.21420662827 0.71082110280715 0.5521208457216557 0.7156616673310627 0.7231743017433075 0.8948302443294872 0.5402524758219593 0.7451950951442909 0.8333592450774229 0.9491818670102189 1.0 15.32098433579777 -8.040522890250278 1.7676560655734745 0.9913253711114212 0.6924929468011533 0.592385251197687 0.0933958399710978 0.2665415881064257 1.4913464771199987 0.0842271831946392 0.027343378964291353 9.109134397145448e-09 8.040522890250278 -0.2988324243102679 RNS(ph)EPPPAAALPLGR ddPTM_A459_Selumetinib_30min_R1 1 RNSEPPPAAALPLGR 15 1 Q3KP66-3;Q3KP66 Q3KP66-3 C1orf106 Uncharacterized protein C1orf106 1 RNS(1)EPPPAAALPLGR 75.743 0.019558 4157800.0 1468.2 1762.6 1704.8 1274.9 1974.5 1386.8 2110.0 1534.5 586.54 911.5 True False 1502.4062033801117 1556.233972589491 1473.2975237960893 1052.2626478369514 1795.9068236262874 1372.850051113654 1950.841001229254 1493.8000752415269 995.3155408133478 1028.499903761865 1.4607742770659249 1.5131104698185909 1.4324722038449613 1.0231042744760317 1.7461419462048924 1.334808147372971 1.8967828719223143 1.4524066261725153 0.9677351812798997 1.0 10.006325943530003 -8.248637607165561 6.8701144105438825 0.9812384336227906 1.4849126411060056 0.4537692359649712 0.21887928655995117 0.12342807175527341 34.04386454806097 0.16553658130200063 0.05568108098833748 5.64108174104624e-09 8.248637607165561 0.503674207483215 RNS(ph)EPPPAAALPLGR ddPTM_A459_Selumetinib_30min_R2 2 RNSEPPPAAALPLGR 15 1 Q3KP66-3;Q3KP66 Q3KP66-3 C1orf106 Uncharacterized protein C1orf106 1 RNS(1)EPPPAAALPLGR;RNS(1)EPPPAAALPLGR 98.227 0.0046294 3879200.0 15069.0 12794.7 11914.3 14812.4 17463.2 14585.2 12299.8 11699.5 15035.900000000001 14783.7 True False 14231.525305986483 13776.012348555225 11147.746909309013 12794.925567184759 15269.31669301118 16594.178908736772 12871.765071591326 11733.543608043516 18043.500138147763 14356.856168334436 0.9912703128819815 0.9595424086604473 0.7764754886864819 0.8912066414237205 1.0635557335100474 1.1558365365069958 0.896558753578751 0.8172780635584472 1.256786299631852 1.0 13.809452245220603 -6.251339438636158 24.01976828879669 1.0219859750913094 0.8993930186659134 0.1920586038245553 0.1265428928127176 771.8775241305208 1835682.5284436522 0.038607855507336156 0.04920967560023892 5.606096399173715e-07 6.251339438636158 -0.12259295642539603 RNS(ph)FSENEK ddPTM_A459_Selumetinib_30min_R1 4 RNSFSENEK 9 1 Q9HCG8 Q9HCG8 CWC22 Pre-mRNA-splicing factor CWC22 homolog 1 RNS(1)FSENEK;RNS(1)FSENEK;RNS(0.961)FS(0.039)ENEK;RNS(1)FSENEK 168.85 0.0013332 407631000.0 16869.1 19895.5 21055.4 23096.1 20355.1 18846.7 19776.2 20047.600000000002 11389.0 15933.300000000001 True False 17262.11720844534 17566.125610832984 18196.192329033413 19062.799702491957 18513.9847989848 18657.119309434456 18284.465312090037 19515.87252421767 19326.30118035123 17978.494258484843 0.9601536680580792 0.9770632266683155 1.0121088044092361 1.0603112490077071 1.0297850605729806 1.0377464898446287 1.0170187252172573 1.0855120703452277 1.074967731028437 1.0 14.133984576331567 -5.375032636443571 2.217743457816707 1.045325245219622 0.9633664410467699 0.5952164154190035 0.024596885214015988 0.22202093311142224 2.0672803762447973 0.007106223611272307 0.021299149526819963 4.216648148909551e-06 5.375032636443571 -0.08195880417285206 RNS(ph)FSENEK ddPTM_A459_Selumetinib_30min_R2 2 RNSFSENEK 9 1 Q9HCG8 Q9HCG8 CWC22 Pre-mRNA-splicing factor CWC22 homolog 1 RNS(0.985)FS(0.015)ENEK;RNS(0.988)FS(0.012)ENEK 72.289 0.034839 63120000.0 42331.0 36017.0 40868.0 40141.0 42650.0 32722.0 30556.0 38537.0 31212.0 40674.0 True False 39978.41248441927 38779.38808709181 38238.59737371402 34673.72655291265 37291.92570416229 37229.15847925877 31976.91454556536 38649.13628985622 37455.27213614539 39499.63593625647 1.012121036987162 0.9817657091744597 0.9680746788507752 0.8778239528300527 0.944108086574344 0.9425190282598619 0.8095496018537718 0.9784681649275765 0.948243477397862 1.0 15.269551735741016 -5.555458802417418 7.790849766116743 0.9238398189681237 0.9916389821696832 0.22626446464641303 0.05083224273284253 0.2768399122595559 55.00377813086496 0.01368837979269468 0.024035640940520166 2.783179376341142e-06 5.555458802417418 0.06779916320155943 RNS(ph)FTPLSSSNTIR ddPTM_A459_Selumetinib_30min_R1 4 RNSFTPLSSSNTIR 14 1 O60825 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 RNS(0.997)FT(0.003)PLSSSNTIR;RNS(0.993)FT(0.007)PLSSSNTIR;RNS(0.973)FT(0.027)PLSSSNTIR;RNS(0.915)FT(0.085)PLSSSNTIR 238.83 3.4427e-19 143922000.0 6653.7 7645.8 7518.2 8558.7 8010.699999999999 6730.0 7091.299999999999 7364.099999999999 3948.7200000000003 6227.5 True False 6808.71826415356 6750.626181564013 6497.269734516518 7064.083711696695 7286.133599403951 6662.302310351091 6556.397531761617 7168.780146032009 6700.689436901975 7026.860285986848 0.9689559756484255 0.9606888292665063 0.9246334024135283 1.0052973055098418 1.0368974624319987 0.948119364723564 0.9330479424554036 1.020196767015303 0.9535822777442534 1.0 12.778664498619067 -5.769101022280779 24.999966543534228 0.9845702018451392 0.9523523435032285 0.1830138760878054 0.032759830307016444 320.18863042091203 1044780.0248721566 0.009610940332844391 0.014566795542203203 1.7017626112699826e-06 5.769101022280779 -0.03221785834191071 RNS(ph)FTPLSSSNTIR ddPTM_A459_Selumetinib_30min_R2 4 RNSFTPLSSSNTIR 14 1 O60825 O60825 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 RNS(0.979)FT(0.021)PLSSSNTIR;RNS(0.998)FT(0.002)PLSSSNTIR;RNS(0.998)FT(0.002)PLSSSNTIR;RNS(0.965)FT(0.035)PLSSSNTIR 101.08 0.0043861 128221000.0 50453.5 46156.0 53182.0 53852.4 64621.0 45770.8 43404.8 43720.3 39947.9 48351.2 True False 47649.49645136302 49696.01678506839 49760.3280201835 46517.610219428374 56502.7322609302 52075.312234046076 45423.20920497953 43847.51883471468 47938.596237585596 46955.1752244954 1.0147868945978378 1.0583714478216484 1.0597410782150531 0.9906812187799322 1.2033334342974418 1.109043081727861 0.9673738621527563 0.9338165308739063 1.0209438258592032 1.0 15.51899655466487 -7.2716808958884105 24.537744367613737 0.975018255945719 1.0736363021502369 0.37780879436181136 0.057736595614846384 605.4977560170795 1450710.9217076423 0.025210793247970098 0.017221239540527865 5.349572825772729e-08 7.2716808958884105 0.09861804620451786 RNS(ph)IEVAGLSHGLEGLR ddPTM_A459_Selumetinib_30min_R1 2 RNSIEVAGLSHGLEGLR 17 1 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 RNS(1)IEVAGLSHGLEGLR;RNS(1)IEVAGLSHGLEGLR 119.0 0.00078162 11390600.0 2052.8 2249.2 2533.5 2652.8999999999996 2316.2 2180.67 2047.4499999999998 2135.69 1450.6399999999999 1877.29 True False 2100.626245946529 1985.862618375289 2189.464615519352 2189.6208161005934 2106.700118958323 2158.7344396899425 1893.0091980885484 2079.044563501189 2461.63012944637 2118.2584578531114 0.9916760809611245 0.9374977878705096 1.033615424691097 1.0336891647867223 0.9945434709102954 1.0191081412595204 0.8936629952169025 0.9814876724761593 1.1621009326412752 1.0 11.048662914178333 -8.222196809846508 24.69285389008533 1.0810505174488816 0.9855986213646079 0.32836027809269874 0.05457037319087258 451.6061181573437 284167.6822258277 0.036329783774089734 0.013730873744141104 5.995193296610898e-09 8.222196809846508 -0.09545189608427374 RNS(ph)IEVAGLSHGLEGLR ddPTM_A459_Selumetinib_30min_R2 4 RNSIEVAGLSHGLEGLR 17 1 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 RNS(1)IEVAGLSHGLEGLR;RNS(1)IEVAGLSHGLEGLR;RNS(1)IEVAGLSHGLEGLR;RNS(1)IEVAGLSHGLEGLR 147.75 0.00019182 21227200.0 45251.1 44337.4 39204.0 40629.5 52086.1 35289.3 33694.0 41234.100000000006 33730.4 43258.1 True False 42736.22501650575 47737.93601278906 36681.65732208779 35095.69201020314 45542.578462357975 40150.08075062973 35260.83776339437 41354.08440432727 40477.42250612064 42009.12625495837 1.0173081143638774 1.1363706001182188 0.8731830578780063 0.8354301824132981 1.0841115377157493 0.955746627695947 0.8393613699411924 0.9844071536585747 0.963538785845208 1.0 15.358415159167084 -5.259717391173537 24.996339067467332 0.9395140362651213 1.0768393581340916 0.327080232447864 0.07731417630424496 171.118251574866 2483896.0241657114 0.020266852259562613 0.04823025759231967 5.498985934460655e-06 5.259717391173537 0.13732532186897028 RNS(ph)LEGYSR ddPTM_A459_Selumetinib_30min_R1 2 RNSLEGYSR 9 1 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 RNS(1)LEGYSR;RNS(1)LEGYSR 151.79 0.00060381 24990000.0 3220.7 4331.4 4506.7 5089.0 4665.8 3834.8 4641.9 3906.8 2315.5 3320.2 True False 3295.7360436087224 3824.2776743867717 3894.71489353111 4200.301682361161 4243.779213813897 3796.225393719816 4291.757745784868 3803.17897292512 3929.2343825711914 3746.3800114867213 0.8797121577372594 1.0207927820085547 1.0395941900153165 1.1211627409613218 1.132767952210429 1.013304945595552 1.1455745900378425 1.0151610251133756 1.0488082817343203 1.0 11.871281530447323 -4.637151627833805 1.6971865794450451 1.071247802342545 0.7574839853836203 0.554662270042791 0.04966132209480367 1.0296322775279145 2.2088936927653613 0.013429601634186416 0.5920935189941441 2.30594196083231e-05 4.637151627833805 -0.31376381695892464 RNS(ph)LEGYSR ddPTM_A459_Selumetinib_30min_R2 2 RNSLEGYSR 9 1 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 RNS(1)LEGYSR;RNS(1)LEGYSR 116.74 0.003981 19980200.0 57708.0 65843.0 66514.0 83620.0 84540.0 49894.0 52118.0 57902.0 54266.0 61342.0 True False 54500.820383427425 70892.94638138625 62234.561654967474 72230.81174745402 73919.32940281084 56766.445607363086 54541.59026985781 58070.485233807885 65120.71631872565 59570.897074343455 0.9148900396012392 1.1900600773715573 1.0447141928599768 1.212518449358102 1.2408631233227994 0.9529224570266172 0.9155744322901641 0.9748130057759062 1.0931632645628304 1.0 15.86232006424721 -6.785793404736556 24.999938268502245 0.9812378869819277 1.1253572826140605 0.3196048082607891 0.0969324363135897 270.62851588312697 277803.9449571984 0.03438227774980573 0.030336294315720276 1.6375953454719735e-07 6.785793404736556 0.14411939563213283 RNS(ph)LGGDVLFVGK ddPTM_A459_Selumetinib_30min_R1 2 RNSLGGDVLFVGK 13 1 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 RNS(1)LGGDVLFVGK;RNS(1)LGGDVLFVGK 135.09 0.00059841 24262600.0 17136.5 19424.9 23139.0 22266.0 20783.7 18345.9 18716.9 17386.5 9834.1 14857.4 True False 17535.74710817552 17150.623677608983 19996.850893428964 18377.661084585117 18903.818004660272 18161.356902744432 17305.06916393736 16925.353540688695 16687.74944575398 16764.492013331354 1.0460052767617924 1.0230327088927342 1.1928098314895075 1.096225347596035 1.1276105467214692 1.0833228282910257 1.032245364200486 1.0095953714093706 0.9954223147640652 1.0 14.033121147742223 -7.37204849378457 2.2277370371316754 1.0017957983139854 1.0989345881326127 0.5000469791089459 0.042838151536032085 0.28705274216914684 2.7816145977649582 0.02362851050663767 0.014095694064330293 4.24572153120411e-08 7.37204849378457 0.09713878981862734 RNS(ph)LGGDVLFVGK ddPTM_A459_Selumetinib_30min_R2 2 RNSLGGDVLFVGK 13 1 Q9H0D6-2;Q9H0D6 Q9H0D6-2 XRN2 5-3 exoribonuclease 2 1 RNS(1)LGGDVLFVGK;RNS(1)LGGDVLFVGK 136.35 0.00056414 13164800.0 132928.0 120831.0 131535.0 133345.0 144314.0 99826.0 92324.0 107551.0 98472.0 132802.0 True False 125540.3939129452 130098.34916709848 123072.18130447973 115183.18096704487 126183.98513647093 113576.12536979646 96617.24893653547 107863.95560397349 118169.15153756576 128967.66119896562 0.973425374592682 1.0087672208491747 0.9542871457877289 0.893116769709775 0.978415704862631 0.8806558505746352 0.7491587273764594 0.8363643614313958 0.9162696325496638 1.0 16.976649827862126 -6.860243208808681 5.219704136745451 0.8559031417479178 0.9597786742037372 0.273184908255661 0.06613549292108901 0.2392776256469165 10.321321078733575 0.023679880321357132 0.02093763280247194 1.3796114534333022e-07 6.860243208808681 0.10387553245581937 RNS(ph)LILK ddPTM_A459_Selumetinib_30min_R2 2 RNSLILK 7 1 Q9NXD2 Q9NXD2 MTMR10 Myotubularin-related protein 10 1 RNS(1)LILK;RNS(1)LILK 80.755 0.022743 6047700.0 70687.0 45654.0 63735.0 72833.0 73110.0 66820.0 81616.0 82659.0 70188.0 49654.0 True False 66758.49952248103 49155.51499925284 59634.35948942113 62913.01975606715 63925.268188307295 76023.84846843309 85411.30571903598 82899.52400506583 84227.56121657607 48220.36000341449 1.3844463110137264 1.0193933640431578 1.236704982816354 1.3046982592334913 1.325690396831976 1.5765923038121206 1.7712705942674007 1.7191809434686034 1.7467219492059352 1.0 15.557354801398267 -6.663546937043248 2.35170809121369 1.627632198582927 1.2218963622983179 0.3053765227664411 0.22622579102888296 0.29366619909032804 3.317290834345829 0.08027238682943079 0.07883412737949659 2.1699666684137524e-07 6.663546937043248 -0.4057358362846091 RNS(ph)LPQIPMLNLEAR ddPTM_A459_Selumetinib_30min_R1 2 RNSLPQIPMLNLEAR 15 1 Q14289;H0YB74;Q14289-2 Q14289 PTK2B Protein-tyrosine kinase 2-beta 1 RNS(1)LPQIPMLNLEAR;RNS(1)LPQIPMLNLEAR 135.18 0.00021089 41263000.0 3618.2 4460.7 4275.7 5234.4 4107.2 3893.3 4325.6 4559.4 2372.12 3373.6 True False 3702.497020208364 3938.4391702768316 3695.0834247389353 4320.310301857196 3735.704485185055 3854.1369368335672 3999.316509439461 4438.4699009815695 4025.314387210009 3806.6344216467664 0.9726431829528426 1.0346250083487256 0.9706956369980037 1.1349422674500513 0.9813667590304018 1.0124788750179616 1.0506174395673487 1.1659827052847036 1.057447062507421 1.0 11.89430030888264 -7.527264847539473 24.999231517753746 1.088688948039816 1.0210408774491804 0.14671345896104504 0.05873541411116869 195.04037322894203 1111633.3228210015 0.026340581532446845 0.015287014798132968 2.9698543612314814e-08 7.527264847539473 -0.06764807059063571 RNS(ph)LPQIPMLNLEAR ddPTM_A459_Selumetinib_30min_R2 1 RNSLPQIPMLNLEAR 15 1 Q14289;H0YB74;Q14289-2 Q14289 PTK2B Protein-tyrosine kinase 2-beta 1 RNS(1)LPQIPMLNLEAR 89.557 0.0084571 4596600.0 15160.0 17477.0 15128.0 16659.0 16451.0 17562.0 14339.0 15998.0 11361.0 18916.0 True False 14317.467890288353 18817.42970258776 14154.680950121014 14390.015461622079 14384.278306194006 19981.00608803687 15005.791912189474 16044.551531388533 13633.517452862601 18369.84593032964 0.7794005428564545 1.0243651347951228 0.7705389040171995 0.7833498177501511 0.7830375040024021 1.087706786644689 0.816870863756896 0.8734178605656177 0.7421683069400655 1.0 14.165051906026937 -5.301039608447643 24.9952757484214 0.8541304906496293 0.9018836354643013 0.022315745650280272 0.11712691038103355 2183.0319775982243 1377904.3712239333 0.03025889151910969 0.06299003865009911 4.999889329962998e-06 5.301039608447643 0.047753144814671966 RNS(ph)LTGEEGQLAR ddPTM_A459_Selumetinib_30min_R1 4 RNSLTGEEGQLAR 13 1 Q9BX95 Q9BX95 SGPP1 Sphingosine-1-phosphate phosphatase 1 1 RNS(1)LTGEEGQLAR;RNS(0.913)LT(0.087)GEEGQLAR;RNS(1)LTGEEGQLAR;RNS(0.832)LT(0.168)GEEGQLAR 130.47 0.00083258 70598000.0 9901.19 13473.99 13355.1 12093.720000000001 13421.72 12709.65 14251.869999999999 12847.529999999999 7755.51 11939.75 True False 10131.868462638009 11896.44898691199 11541.550774313204 9981.778829240486 12207.727795797135 12581.802460438883 13176.839971653631 12506.771769741137 13160.534029961 13472.333215513694 0.7520500198860087 0.88302811373556 0.8566853706544942 0.7409094378504715 0.9061331545555644 0.9338992926593187 0.9780666615698166 0.928330050160822 0.9768563336012466 1.0 13.717712106144194 -6.521892794463463 3.575628075011186 0.9588477727191121 0.8166405034307158 0.7218514265591378 0.04511022519023126 0.13410578069071522 3.6921283672706955 0.015044355379080391 0.015980344854430346 3.006818443768648e-07 6.521892794463463 -0.14220726928839633 RNS(ph)LTGEEGQLAR ddPTM_A459_Selumetinib_30min_R2 1 RNSLTGEEGQLAR 13 1 Q9BX95 Q9BX95 SGPP1 Sphingosine-1-phosphate phosphatase 1 1 RNS(0.989)LT(0.011)GEEGQLAR 73.593 0.026379000000000003 8067300.0 13942.0 11116.0 11441.0 10166.0 12048.0 9444.1 13106.0 13274.0 8298.2 9551.2 True False 13167.159454248029 11968.561456426482 10704.898516018933 8781.373262671834 10534.422529513422 10744.939049995954 13715.454969046328 13312.625142370998 9958.071871080409 9275.432039002137 1.4195737081444424 1.290350832834529 1.1541131961299542 0.9467346885565177 1.1357338919866344 1.158430033750957 1.4786863740011678 1.4352566097614563 1.0735965536923615 1.0 13.179198767043433 RNS(ph)PAFLSTDLGDEDVGLGPPAPR ddPTM_A459_Selumetinib_30min_R1 2 RNSPAFLSTDLGDEDVGLGPPAPR 24 1 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4;A0A590UJF3 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 RNS(0.999)PAFLS(0.001)TDLGDEDVGLGPPAPR;RNS(0.999)PAFLS(0.001)TDLGDEDVGLGPPAPR 111.67 1.5639e-07 12729400.0 2020.5700000000002 2143.12 2089.16 2240.17 2430.48 1859.31 1669.4499999999998 1567.94 807.24 1415.1499999999999 True False 2067.6453496551926 1892.2025140905419 1805.463546934441 1848.966362698959 2210.6435131360954 1840.6070295184068 1543.522042418093 1526.3531378130983 1369.8273215231131 1596.798287228309 1.2948694686065645 1.184997835496799 1.1306772817675856 1.1579210583375303 1.3844225227553864 1.1526859993777274 0.9666355824424813 0.9558835013923469 0.8578587116979143 1.0 10.640966362974604 -7.2220370523947155 3.427316502909013 0.9363599051937094 1.22200609574547 0.7612110246944532 0.07564234495892794 0.1243002838900814 3.0203159415146694 0.033171559553458276 0.023785325488303075 5.99739906487908e-08 7.2220370523947155 0.28564619055176055 RNS(ph)SDSAIDNPKPNK ddPTM_A459_Selumetinib_30min_R2 1 RNSSDSAIDNPKPNK 15 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RNS(0.917)S(0.08)DS(0.003)AIDNPKPNK 81.278 0.010797 2188100.0 8252.8 6216.1 7274.0 7352.9 7551.6 6990.9 9025.6 12362.0 7758.8 7256.0 True False 7794.142414575974 6692.854882088217 6805.998759332384 6351.42233554001 6602.900495839441 7953.833017928304 9445.308283887118 12397.971373360724 9310.776798985153 7046.500426647912 1.1061011768481113 0.9498125987160513 0.9658693460932725 0.9013583979248324 0.9370467744341717 1.1287635757246408 1.340425418576231 1.7594508795422805 1.3213334613270404 1.0 12.782691220097655 -7.151273025033805 2.711513133346913 1.4248300516568364 0.969390566262718 0.48145985431257987 0.18249448114942027 0.20428752203497663 2.914931474358283 0.07628603263172169 0.05561568151316699 7.058736578323266e-08 7.151273025033805 -0.4554394853941184 RNS(ph)SEASSGDFLDLK ddPTM_A459_Selumetinib_30min_R1 9 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 RNS(0.939)S(0.06)EASSGDFLDLK;RNS(0.482)S(0.482)EAS(0.029)S(0.006)GDFLDLK;RNS(0.73)S(0.263)EASS(0.007)GDFLDLK;RNS(0.949)S(0.049)EAS(0.002)SGDFLDLK;RNS(0.958)S(0.042)EASSGDFLDLK;RNS(0.499)S(0.499)EASS(0.001)GDFLDLK;RNS(0.552)S(0.425)EAS(0.006)S(0.017)GDFLDLK;RNS(0.5)S(0.5)EASSGDFLDLK;RNS(0.897)S(0.103)EASSGDFLDLK 243.99 8.253299999999997e-21 6631349300.0 78710.06 112560.7 69012.41 71782.48999999999 74188.06 74930.54000000001 90870.1 86746.7 49326.450000000004 86635.12 True False 80543.85125488402 99382.0409159503 59640.90378003313 59247.025645720765 67477.76307196586 74176.80679908684 84015.69519706271 84445.89572300698 83703.38298863263 97755.58154953107 0.8239309712875458 1.0166380204653085 0.6101022860757481 0.6060730723155825 0.6902701820435291 0.7587986856945118 0.8594465284265472 0.8638473055394765 0.856251701047081 1.0 16.57689145786651 -8.163359228180056 0.8796916667591161 0.9815497347620897 0.75092825609352 0.3016999436347203 0.11364681220908271 0.789348958745132 1.2476688115215295 0.11912535174011886 0.04473269525071461 6.865003639574776e-09 8.163359228180056 -0.23062147866856975 RNS(ph)SEASSGDFLDLK ddPTM_A459_Selumetinib_30min_R2 22 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 RNS(0.998)S(0.002)EASSGDFLDLK;RNS(0.782)S(0.218)EASSGDFLDLK;RNS(0.933)S(0.066)EAS(0.001)S(0.001)GDFLDLK;RNS(0.991)S(0.007)EAS(0.001)S(0.001)GDFLDLK;RNS(0.5)S(0.5)EASSGDFLDLK;RNS(0.695)S(0.305)EASSGDFLDLK;RNS(0.771)S(0.229)EASSGDFLDLK;RNS(0.903)S(0.097)EASSGDFLDLK;RNS(0.65)S(0.35)EASSGDFLDLK;RNS(0.497)S(0.497)EAS(0.004)S(0.002)GDFLDLK;RNS(0.641)S(0.358)EASSGDFLDLK;RNS(0.808)S(0.192)EASSGDFLDLK;RNS(0.694)S(0.306)EASSGDFLDLK;RNS(0.904)S(0.096)EASSGDFLDLK;RNS(0.608)S(0.392)EASSGDFLDLK;RNS(0.936)S(0.064)EASSGDFLDLK;RNS(0.885)S(0.115)EASSGDFLDLK;RNS(0.73)S(0.268)EAS(0.001)S(0.001)GDFLDLK;RNS(0.5)S(0.5)EASSGDFLDLK;RNS(0.641)S(0.358)EASS(0.001)GDFLDLK;RNS(0.708)S(0.292)EASSGDFLDLK;RNS(0.809)S(0.191)EASSGDFLDLK 227.41 1.8740999999999998e-13 8624425000.0 3171037.6999999997 2591696.8 2947828.9000000004 3561205.4 3527978.3000000003 3084859.2 3525783.2 3648268.8000000003 3209021.4999999995 3127218.0000000005 True False 2994804.119303684 2790471.6109413374 2758168.7979274285 3076163.081098022 3084762.125427825 3509770.553236339 3689739.1050068694 3658884.6582045835 3850915.4675522745 3036927.090851855 0.9861297389472873 0.9188470870265815 0.9082104098698547 1.0129196352340357 1.0157511303844151 1.155697996112199 1.214958079211543 1.2047983203897956 1.268030266236025 1.0 21.534180842686617 -6.6256769241962195 1.6877768436248077 1.1919759500705052 0.9449544032381847 0.6664111775367162 0.07141373861898165 0.19398155581214843 1.1361505609632192 0.02753776087869753 0.02786144927907802 2.367680382509191e-07 6.6256769241962195 -0.24702154683232047 RNS(ph)SS(ph)PVSPASVPGQR ddPTM_A459_Selumetinib_30min_R2 1 RNSSSPVSPASVPGQR 16 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 2 RNS(0.981)S(0.106)S(0.765)PVS(0.148)PASVPGQR 109.14 0.010159 3706400.0 18101.0 14945.0 20076.0 20532.0 18470.0 14939.0 15982.0 12907.0 13672.0 16243.0 True False 17095.01888404416 16091.233444250967 18784.332017096083 17735.506180324428 16149.633476104991 16996.71164726014 16725.194667732212 12944.557233131127 16406.78202759771 15774.02238561769 1.0837450629987007 1.0201097127212462 1.1908396956646332 1.1243489927144494 1.023812004402236 1.0775128392588857 1.060299919631265 0.8206250071594681 1.0401140322050608 1.0 13.94526297473344 -7.549310253849001 24.634730510828764 0.9463140547678301 1.0857511854224087 0.4245579708648468 0.0694470293411005 167.73421434435966 156329.5726360705 0.03186476657611676 0.018397770540664347 2.8228626411901985e-08 7.549310253849001 0.13943713065457852 RNS(ph)SSPVS(ph)PASVPGQR ddPTM_A459_Selumetinib_30min_R2 1 RNSSSPVSPASVPGQR 16 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 2 RNS(0.954)S(0.046)S(0.013)PVS(0.986)PAS(0.001)VPGQR 162.76 7.7876e-05 0.0 20757.0 19262.0 19805.0 23835.0 18492.0 16433.0 18842.0 17673.0 13723.0 21018.0 True False 19603.409036854573 20739.333462908122 18530.76786205359 20588.631882331614 16168.8696394225 18696.49658607845 19718.190334714705 17724.425504077353 16467.983452656754 20411.15572867775 0.9604262148326912 1.0160783513972842 0.9078745029620148 1.0086950565667632 0.79215845757843 0.9159940198687428 0.9660496738560754 0.8683695200646806 0.8068128856377875 1.0 14.317070253092352 -6.228168138649325 24.99145272805721 0.8899282965418093 0.9716553738180472 0.2708445976532675 0.06562088458961121 888.0988123546897 667088.8481922069 0.01908459934407197 0.024636572284617343 5.913326533184784e-07 6.228168138649325 0.08172707727623796 RNS(ph)SSSSSPSERPR ddPTM_A459_Selumetinib_30min_R2 2 RNSSSSSSPSERPR 14 2 B7WPE2;Q32P44;G3V1D0;H0Y3M3;Q32P44-2 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 RNS(0.453)S(0.453)S(0.065)S(0.027)S(0.001)SPSERPR;RNS(0.986)S(0.007)S(0.005)S(0.002)S(0.001)SPSERPR 82.837 0.025845 5907480.0 980.76 361.87 862.18 605.43 0.0 686.95 603.56 2250.8 980.26 1078.7 True False 926.2532854933509 389.6242654045565 806.7082774706064 522.9693895749961 0.0 781.5711269887779 631.626735931451 2257.3494553600012 1176.3393907528473 1047.555128200814 0.8842048122891631 0.3719367648686327 0.7700867054664089 0.49922851360882653 0.0 0.7460906886410207 0.6029532183344622 2.1548741394040243 1.1229379333698855 1.0 10.03281045325416 -7.650712297087948 8.984161157395613 1.4767964655956907 0.5339670521081609 0.541219179768829 0.36732929216998306 0.17925591670298396 13.465718257307131 0.16554852137101655 0.09527703953163105 2.2350523662743297e-08 7.650712297087948 -0.9428294134875298 RNS(ph)TIVLR ddPTM_A459_Selumetinib_30min_R1 1 RNSTIVLR 8 1 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6;Q8NEY1-5;H0Y6F6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 RNS(0.921)T(0.079)IVLR 123.51 0.003016 6024700.0 1554.1 1841.4 1456.6 1856.2 1584.3 1373.5 1368.7 1679.0 852.06 1430.9 True False 1590.3075062478076 1625.8080319563637 1258.801720531078 1532.0495151893858 1441.0003447308832 1359.6838370382195 1265.457857053308 1634.4674658393758 1445.8835879998317 1614.5699531463001 0.9849728115829156 1.0069604161703642 0.7796513976232871 0.9488901439072941 0.8924979322963473 0.8421337424176722 0.7837739421493135 1.0123237228924653 0.8955224177077303 1.0 10.656934233431242 -8.615473341318413 1.2593275839408447 0.9955734325715697 0.8976536333693684 0.10408608201066294 0.08083366530992259 1.3323741224221664 4.500770519926037 0.07848824953971381 0.024021206964756736 2.4239667524790918e-09 8.615473341318413 -0.09791979920220129 RNS(ph)TIVLR ddPTM_A459_Selumetinib_30min_R2 4 RNSTIVLR 8 1 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6;Q8NEY1-5;H0Y6F6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 RNS(0.917)T(0.083)IVLR;RNS(0.909)T(0.091)IVLR;RNS(0.934)T(0.066)IVLR;RNS(0.897)T(0.103)IVLR 138.22 0.0012741 17103500.0 52953.0 36114.5 43514.8 51149.0 42506.5 33511.0 34929.0 34522.3 29431.4 39986.3 True False 50010.0842476543 38884.36602357988 40715.10514333197 44182.41796305351 37166.45345706857 38126.83606742984 36553.26771050047 34622.75417752557 35318.50238202449 38831.79162211566 1.2878644574094882 1.0013539009988475 1.0484992693498003 1.1377898396501112 0.9571140528036146 0.981845917346643 0.9413232349980597 0.891608466445495 0.9095254405390282 1.0 15.244950651429178 -1.5228787452837613 0.37802636976549225 0.9299310989409927 5.089875961618119 0.644434619521179 0.0672753786523822 44.96775162547756 0.6153973414258518 0.053391786263637595 136.79753977809128 0.029999999999763494 1.5228787452837613 4.159944862677126 RNS(ph)TTFPSR ddPTM_A459_Selumetinib_30min_R1 1 RNSTTFPSR 9 1 Q96E09 Q96E09 FAM122A Protein FAM122A 1 RNS(0.855)T(0.072)T(0.072)FPSR 174.57 0.00062448 9576100.0 3723.6 4114.9 4623.1 4395.4 4558.7 3888.2 4394.6 3792.3 2302.1 3253.8 True False 3810.3526351356686 3633.1255950348877 3995.308412870539 3627.825901876645 4146.366389903856 3849.0882382031364 4063.1117838872433 3691.715884873537 3906.495561268469 3671.4569246959486 1.0378312243037477 0.9895596406420497 1.088207895344274 0.9881161555986614 1.1293517736823881 1.0483816961905112 1.106675596969922 1.0055179621041765 1.0640178112921712 1.0 11.842136958339871 -2.859146491108343 18.231586187457292 1.0480221529726597 1.026055028566755 0.0 0.04811320012004516 0.0 0.0 0.010427829696888836 0.0 0.0013830997693284116 2.859146491108343 -0.02196712440590476 RNS(ph)TTIMSR ddPTM_A459_Selumetinib_30min_R1 2 RNSTTIMSR 9 1 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 RNS(0.877)T(0.062)T(0.062)IMSR;RNS(0.8)T(0.1)T(0.1)IMSR 147.28 0.0029731 103560000.0 8640.0 9652.099999999999 10051.5 10610.7 10061.6 8262.4 9514.599999999999 8896.8 5060.9 7275.9 True False 8841.295189486567 8522.027644860442 8686.561508937344 8757.74043250729 9151.530056519754 8179.287757658968 8796.906061751593 8660.827963120762 8587.977666488685 8209.832638267646 1.0769153987714135 1.038026963562886 1.0580680376415434 1.0667379980056764 1.1147036072163847 0.9962794758487156 1.0715085738468628 1.0549335589072715 1.0460600166754228 1.0 13.003137096871946 -10.072174054074289 0.39461312313305114 0.9832653521810639 1.0627585428798592 0.2924188086918156 0.028193912174942267 11.823057408696922 1.721443179896163 0.283647718341088 0.01913132619374784 8.468879351842604e-11 10.072174054074289 0.07949319069879524 RNS(ph)TTIMSR ddPTM_A459_Selumetinib_30min_R2 1 RNSTTIMSR 9 1 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 RNS(0.956)T(0.034)T(0.01)IMSR 92.112 0.013515 67420000.0 20122.0 22020.0 22227.0 26057.0 28704.0 19567.0 17907.0 22666.0 13890.0 23816.0 True False 19003.69979474816 23708.863194540383 20796.93901892781 22507.991649167816 25097.946902984164 22262.176638459005 18739.71098204734 22731.95430744171 16668.388119026633 23128.370198600696 0.8216618651277865 1.0250987419759827 0.8991960453913029 0.973176728662428 1.0851584736611761 0.9625484393105184 0.8102477961538822 0.982860189120331 0.7206901297366426 1.0 14.49737598580717 -7.152015946462702 9.057906240415452 0.8771423686603663 0.967759077417386 0.14109339545631527 0.09918432773657133 0.6357809265868148 48.213475984080425 0.03613223394865875 0.02798195386290363 7.046671944605531e-08 7.152015946462702 0.09061670875701966 RNS(ph)VERPAEPVAGAATPSLVEQQK ddPTM_A459_Selumetinib_30min_R1 1 RNSVERPAEPVAGAATPSLVEQQK 24 2 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 RNS(1)VERPAEPVAGAATPSLVEQQK 61.736 0.007224299999999999 15024000.0 826.83 927.24 1171.2 1084.9 938.43 1026.5 1109.4 883.72 637.23 918.52 True False 846.0935302688857 818.6783097378185 1012.1574729410959 895.4425810952295 853.5491721932734 1016.1743419874285 1025.717064816936 860.2808748728845 1081.3327685622291 1036.4209891424562 0.8163608602416967 0.7899090411273899 0.9765891308111811 0.8639757303990211 0.8235545025960035 0.9804648426005151 0.9896722235098918 0.8300496457377696 1.0433335294154293 1.0 10.01739442241461 -1.5228787546214966 0.16504207552998276 1.0152397102146653 0.18966398177768712 0.38898487524037895 0.07025458410393288 68.83601654202647 0.7293307728369706 0.1958274415388751 13.919904963313925 0.0299999993547356 1.5228787546214966 -0.8255757284369782 RNS(ph)VERPAEPVAGAATPSLVEQQK ddPTM_A459_Selumetinib_30min_R2 1 RNSVERPAEPVAGAATPSLVEQQK 24 2 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 RNS(1)VERPAEPVAGAATPSLVEQQK 78.324 0.00036442 15235000.0 6420.9 6007.9 6792.7 8306.3 7393.9 5109.4 4387.6 5065.1 4661.1 6375.9 True False 6064.052082899241 6468.686611556728 6355.665077332565 7174.967610833272 6465.0121796953235 5813.173471484768 4591.632093864462 5079.838602427559 5593.450242015483 6191.811200422326 0.9793664384478696 1.0447163846203058 1.026462996303741 1.1587833314982035 1.0441229505276846 0.9388486314130942 0.7415652618011479 0.8204123862951567 0.9033625317312598 1.0 12.596145766421046 -6.9147788455277635 3.6570943123504907 0.8498407938098524 1.0548500321898442 0.5700856806908305 0.07495472677171922 0.1550048307729831 4.069136620028629 0.027927154863364476 0.024140379360470258 1.2168054730966584e-07 6.9147788455277635 0.20500923837999174 RNS(ph)VTPLASPEPTK ddPTM_A459_Selumetinib_30min_R1 2 RNSVTPLASPEPTK 14 1 Q5W015;Q5VX20;A0A1W2PR17;Q16875-3;Q16875-2;Q16875;Q16875-4;Q9H178 Q5W015 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 RNS(0.988)VT(0.012)PLASPEPTK;RNS(0.995)VT(0.005)PLASPEPTK 137.69 0.00030028 33213000.0 15036.4 20464.0 13876.2 16390.1 15370.3 14158.5 16359.3 15366.7 7946.0 14437.8 True False 15386.718864258772 18068.065366544506 11991.888256510618 13527.876715281525 13980.059078846865 14016.078344889436 15125.304830052004 14959.125197923739 13483.781647121863 16291.032266081254 0.9444901104452842 1.1090804481532532 0.7361036465122183 0.8303879394706769 0.8581444595106504 0.8603554468473807 0.9284436113691609 0.9182429298276812 0.8276812314217664 1.0 13.99179040133633 -5.250549305725797 24.99248469859104 0.8669161472351861 1.0267852730046756 0.4048038890887895 0.07601445527646623 681.010179623917 1562896.441779088 0.018880791711591745 0.04891252861488363 5.616305124705479e-06 5.250549305725797 0.15986912576948953 RNS(ph)VTPLASPEPTK ddPTM_A459_Selumetinib_30min_R2 1 RNSVTPLASPEPTK 14 1 Q5W015;Q5VX20;A0A1W2PR17;Q16875-3;Q16875-2;Q16875;Q16875-4;Q9H178 Q5W015 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 RNS(0.997)VT(0.003)PLASPEPTK 220.52 1.3656e-08 25535000.0 44155.0 44834.0 48312.0 48891.0 44861.0 26944.0 33102.0 34430.0 29712.0 41724.0 True False 41701.0418664698 48272.623635968375 45203.65851812838 42231.961458320766 39225.160117571504 30655.291426720465 34641.30859036863 34530.18559980667 35655.23022264359 40519.31970802886 1.0291644126050514 1.1913483243007954 1.1156075384249684 1.0422672878674355 0.9680606782201006 0.7565598743417736 0.8549331242475053 0.8521906549424261 0.8799562894827809 1.0 15.306322332017917 -6.302034043770087 2.2068251207350587 0.8594962127552382 1.1146571960348346 0.6981748085884198 0.0696221121023783 0.15747348786503293 1.5058115405754702 0.022891237031386975 0.028583159914949183 4.988453820975379e-07 6.302034043770087 0.25516098327959635 RNSNSPPS(ph)PSSMNQR ddPTM_A459_Selumetinib_30min_R2 1 RNSNSPPSPSSMNQR 15 1 Q7Z5L9;Q7Z5L9-2;Q7Z5L9-3 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 RNS(0.161)NS(0.357)PPS(0.453)PS(0.015)S(0.015)MNQR 62.556 0.038803 1041900.0 2692.4 3411.8 3314.9 4245.5 3923.1 1101.8 1603.8 913.44 1128.7 4571.0 True False 2542.767186531158 3673.4740893339213 3101.622942990225 3667.2555761040035 3430.2451050410127 1253.5629488554277 1678.3798778694093 916.097959171867 1354.4715385129846 4439.023353115713 0.5728213132166586 0.8275410596241943 0.6987174196353849 0.8261401854374089 0.7727477042069069 0.28239611489666133 0.3780966542316946 0.20637376429409088 0.30512827502074136 1.0 12.116026583173168 -6.754395121490962 24.999267491831898 0.38127841815125485 0.7470168208230417 0.3150079246918026 0.21796294179085474 158.76614385399844 563442.3509877005 0.0680475157696368 0.06665658394363984 1.760373728103904e-07 6.754395121490962 0.3657384026717868 RNSS(ph)EASSGDFLDLK ddPTM_A459_Selumetinib_30min_R1 2 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 RNS(0.233)S(0.765)EAS(0.002)SGDFLDLK;RNS(0.348)S(0.648)EASS(0.003)GDFLDLK 124.78 0.00066052 4435900.0 3011.82 3765.1 3063.8999999999996 3071.6 3122.7 3108.4 3523.1000000000004 3295.4 1897.22 3261.3999999999996 True False 3081.9895460184525 3324.2803416524957 2647.839208798004 2535.2027210730107 2840.252336357464 3077.1323182013866 3257.349730535919 3207.99528703221 3219.4437725336716 3680.0324587262176 0.8374897723280496 0.903329081723138 0.7195151777858259 0.6889077065234716 0.7718008925770645 0.8361698851065257 0.8851415760782168 0.8717301608102133 0.8748411348654324 1.0 11.845502775900036 -7.126610144137513 2.1638534605822377 0.9014883138020794 0.7824682840783019 0.44560862804388834 0.06485682663384461 0.364748686648002 3.354382527991327 0.03263423127902465 0.02338379747946648 7.471191286104022e-08 7.126610144137513 -0.11902002972377745 RNSS(ph)EASSGDFLDLK ddPTM_A459_Selumetinib_30min_R2 5 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 RNS(0.341)S(0.658)EASSGDFLDLK;RNS(0.123)S(0.877)EASSGDFLDLK;RNS(0.389)S(0.61)EASSGDFLDLK;RNS(0.093)S(0.669)EAS(0.017)S(0.222)GDFLDLK;RNS(0.119)S(0.851)EAS(0.015)S(0.015)GDFLDLK 150.13 0.00013955 7752000.0 83453.3 65784.7 76445.0 79866.3 85017.29999999999 69124.6 84231.9 83656.0 72754.49999999999 73988.5 True False 78815.29967602917 70830.17495885023 71526.6119270227 68988.37216294797 74336.66670969466 78645.8861993572 88148.85025234336 83899.42511000369 87307.43293057763 71852.25975979032 1.0969077373421103 0.9857751891957605 0.9954678136240073 0.9601419968360545 1.0345766014626399 1.0945499342996128 1.2268069305966751 1.1676657824052898 1.2150965498156299 1.0 16.13274590982951 -6.890356437922787 2.8691970246683494 1.166189057720765 1.0072545030323876 0.4759187829457572 0.06744121206181594 0.19793235314640706 3.2866308946112217 0.024786359670367353 0.02139465070711393 1.2871926821417032e-07 6.890356437922787 -0.15893455468837736 RNSS(ph)SPVSPASVPGQR ddPTM_A459_Selumetinib_30min_R1 2 RNSSSPVSPASVPGQR 16 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RNS(0.01)S(0.749)S(0.241)PVSPASVPGQR;RNS(0.136)S(0.432)S(0.432)PVSPASVPGQR 104.35 0.0020095 26161100.0 2373.5 1743.3200000000002 3419.3999999999996 3423.7 2749.8 2187.49 2004.44 1903.41 1300.56 1442.37 True False 2428.797931972956 1539.21128395252 2955.064261419724 2825.8150658085897 2501.081075516621 2165.485836682007 1853.243477016097 1852.9253836529651 2206.9553308558793 1627.5122393735626 1.4923377368318977 0.945744828650241 1.8156940328492661 1.736278841685553 1.536751008692444 1.3305496476730112 1.1386971060379978 1.138501658436784 1.3560299440238601 1.0 10.668452677587343 -6.993001668617253 3.3887463170859045 1.1723063167277448 1.5031337568255903 0.3339686013218106 0.23038625104824292 0.32894874283028136 7.966788484937806 0.0955184603526089 0.07827812202895659 1.016244788315342e-07 6.993001668617253 0.3308274400978455 RNSSEASS(ph)GDFLDLK ddPTM_A459_Selumetinib_30min_R2 1 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 RNS(0.047)S(0.044)EAS(0.003)S(0.906)GDFLDLK 67.13600000000001 0.031405 3091900.0 12309.0 9894.1 14648.0 12544.0 14359.0 10328.0 8714.2 12028.0 11194.0 11458.0 True False 11624.915056831092 10652.945655454223 13705.563627536527 10835.485560393021 12555.094048911289 11750.588251750638 9119.427566859722 12062.999488657413 13433.112786492735 11127.17776854076 1.0447316739827377 0.9573807372407309 1.231719660872633 0.9737856072568173 1.1283269046359263 1.0560259300406265 0.8195633930323791 1.084102342892593 1.2072344907143853 1.0 13.44180010200133 -7.019074159890442 24.985629819562945 1.0208851859295816 1.0677536489999873 0.024492159458015972 0.11479777167513784 3346.8781682888252 4384132.890386696 0.044084188479142486 0.03470963220245132 9.570306353083266e-08 7.019074159890442 0.04686846307040571 RNSSEASSGDFLDLK ddPTM_A459_Selumetinib_30min_R1 2 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 ; 188.9 3.4544e-05 10620300.0 8289.9 10702.400000000001 6766.8 6847.9 8648.8 7753.299999999999 10236.0 9102.8 5088.9 9275.7 False True 8483.038540662577 9449.358032589224 5847.905727371762 5652.042816003337 7866.517567069661 7675.308841433147 9463.890278949124 8861.364173938457 8635.491621449597 10466.32644796921 0.8105077347657687 0.9028342541735539 0.5587352693844587 0.5400216440888873 0.7516025423223835 0.7333335989077996 0.9042227304868186 0.8466546708618892 0.8250737892018597 1.0 13.35346754242242 -7.180264241960489 3.970800779990937 0.8816501527949033 0.7080599368020347 0.3848671046519895 0.10961303117344269 0.29483433604416703 8.74929786381385 0.04845449028690238 0.03633068694472439 6.602915782200626e-08 7.180264241960489 -0.1735902159928686 RNSSEASSGDFLDLK ddPTM_A459_Selumetinib_30min_R2 1 RNSSEASSGDFLDLK 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 103.66 0.0074545 2710400.0 29417.0 24298.0 26977.0 30184.0 30751.0 27254.0 28408.0 33485.0 27420.0 30579.0 False True 27782.12090558129 26161.578469615895 25241.329190336757 26072.88712969572 26887.78446257198 31007.991112820677 29729.028289384078 33582.43580625981 32904.766178812824 29696.10481621644 0.9355476442960976 0.8809767688902279 0.8499878804493234 0.8779901367891806 0.9054313563672872 1.0441770496407947 1.0011086798545261 1.1308700590227283 1.1080499069643706 1.0 14.857986087314021 -6.819157956236285 1.8780823691163615 1.0733347195435634 0.8808228359204764 0.7804449220850997 0.04404039732701241 0.15007497505254586 1.0903237571977127 0.018692203891727394 0.016418401388253494 1.5164987049253358e-07 6.819157956236285 -0.19251188362308702 RNSSS(ph)PVSPASVPGQR ddPTM_A459_Selumetinib_30min_R1 2 RNSSSPVSPASVPGQR 16 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RNS(0.004)S(0.07)S(0.925)PVSPASVPGQR;RNS(0.074)S(0.219)S(0.706)PVS(0.001)PASVPGQR 112.82 0.0012216 20163000.0 1492.71 1177.19 2343.13 2715.29 2322.6 1821.5700000000002 1582.3200000000002 1673.99 1143.43 1018.73 True False 1527.4872386919542 1039.3640475392167 2024.9458158917942 2241.1155738059415 2112.521240088336 1803.2466596532295 1462.96432846686 1629.5903473141502 1940.3171971770144 1149.4939187705152 1.3288345538406467 0.9041927326165483 1.7615976760082834 1.949654136668258 1.8377837460400515 1.5687309260252202 1.272702973523887 1.4176589546964637 1.6879751736767379 1.0 10.166783118371223 -10.616222539851202 4.830414191395402 0.9999780293873497 1.5264621695574447 0.22382831183795993 0.2935442326926302 7.690333652659326e-05 1.443427404098196e-05 0.3147046279737859 0.07632390261033294 2.4197887882226493e-11 10.616222539851202 0.526484140170095 RNSSS(ph)PVSPASVPGQR ddPTM_A459_Selumetinib_30min_R2 1 RNSSSPVSPASVPGQR 16 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RNS(0.201)S(0.201)S(0.593)PVS(0.005)PASVPGQR 82.94200000000002 0.03459 4271900.0 15883.0 17414.0 16573.0 18538.0 18960.0 10981.0 6739.6 8257.6 5029.8 16886.0 True False 15000.286444686675 18749.59780516469 15506.711223318058 16013.092420166284 16578.075295449413 12493.533074406834 7053.004754264045 8281.628248880732 6035.900544354223 16398.45730490307 0.9147376589017098 1.143375712516484 0.9456201235881876 0.9764999305988641 1.0109533468427325 0.7618724641049814 0.4301017237856409 0.505024838306257 0.3680773399671879 1.0 14.001272478340868 -6.968454447728507 3.231998040652863 0.5362725752550872 1.0020373137874015 0.5736747725461951 0.17019719438114966 0.156954963437477 3.3950519638425747 0.062226904787250674 0.05170653459320741 1.0753393846550256e-07 6.968454447728507 0.46576473853231426 RNSSSPVS(ph)PASVPGQR ddPTM_A459_Selumetinib_30min_R1 1 RNSSSPVSPASVPGQR 16 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RNS(0.002)SS(0.004)PVS(0.994)PASVPGQR 173.77 7.2308e-06 2780700.0 1827.4 2072.7 2762.7 3114.2 2353.6 2227.3 2302.9 1805.8 1001.0 1543.1 True False 1869.9748644985816 1830.027320427912 2387.540514424833 2570.3634307740476 2140.7172955618294 2204.8953842265933 2129.1903989245743 1757.9043179349287 1698.623889852628 1741.1719160668508 1.0739748598304324 1.0510319535602075 1.3712261795596095 1.476226102118776 1.2294692303546426 1.2663283641785652 1.2228490359149726 1.009609850534389 0.9755635696730425 1.0 10.765842940386506 -7.753959149686199 4.084808149301675 0.9880953094447603 1.251079826430854 0.4822468371050824 0.11727211209003621 0.20118111419403978 7.566661289995842 0.07231230846943722 0.036041547398081034 1.7621417880055265e-08 7.753959149686199 0.2629845169860937 RNSVT(ph)PLASPEPTK ddPTM_A459_Selumetinib_30min_R1 2 RNSVTPLASPEPTK 14 1 Q5W015;Q5VX20;A0A1W2PR17;Q16875-3;Q16875-2;Q16875;Q16875-4;Q9H178 Q5W015 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 RNS(0.028)VT(0.972)PLASPEPTK;RNS(0.009)VT(0.991)PLASPEPTK 246.75 3.5924e-25 27794000.0 4821.3 6766.1 4611.4 5056.4 4714.2 4339.1 5259.700000000001 4833.3 2120.8 4540.8 True False 4933.626909383285 5973.921866525446 3985.197208607043 4173.394660383374 4287.801442359608 4295.452593587577 4862.956594391235 4705.105183228981 3598.8427028965616 5123.655911137549 0.9629114434985401 1.165949074281048 0.777803443034537 0.8145345301801894 0.8368636607776486 0.8383569599688253 0.9491184963885614 0.9183101412023507 0.7023974219411526 1.0 12.322957876664058 -5.265866628063781 24.983540537585398 0.852476346903574 1.0644302613912247 0.4498902605104206 0.09275322319053385 286.7357360935587 1618096.8850658864 0.023289277016992863 0.05134551186142964 5.421673645617158e-06 5.265866628063781 0.21195391448765066 RNT(ph)LDVGEVLSK ddPTM_A459_Selumetinib_30min_R1 2 RNTLDVGEVLSK 12 1 E7EUN2 E7EUN2 AGAP1 1 RNT(1)LDVGEVLSK;RNT(1)LDVGEVLSK 127.2 0.0032785 10150900.0 5706.8 6855.200000000001 7289.0 7328.0 6521.8 6864.0 6943.799999999999 6195.9 3824.8 5216.5 True False 5839.75733650022 6052.58999710398 6299.193835611037 6048.3023635965 5931.90434151731 6794.954392013351 6420.023575514545 6031.564604880398 6490.406247660673 5886.088588012914 0.9921286859992137 1.0282872754294163 1.0701833214741987 1.0275588403331095 1.0077837349573195 1.1544091276253219 1.0907113407346596 1.0247152272162108 1.1026688012950498 1.0 12.52309354024742 RNT(ph)LDVGEVLSK ddPTM_A459_Selumetinib_30min_R2 2 RNTLDVGEVLSK 12 1 E7EUN2 E7EUN2 AGAP1 1 RNT(1)LDVGEVLSK;RNT(1)LDVGEVLSK 106.87 0.010885 5820300.0 44638.0 44775.0 49194.0 58632.0 57063.0 46968.0 44421.0 40953.0 41795.0 55774.0 True False 42157.19866007198 48209.098525683265 46028.911598377395 50646.22045415849 49894.23579030747 53437.41566694654 46486.66451854163 41072.16644986586 50155.167849871694 54163.65970174483 0.7783299520788092 0.8900635369018511 0.8498116975817019 0.9350590549649836 0.9211754904497375 0.9865916734800161 0.858262989881463 0.7582974761312659 0.9259929651366596 1.0 15.725037601017416 -3.8961235967305528 1.2943160826057727 0.8999984733593627 2.990360599141143e-13 0.24024697377702886 0.0664760436116988 19.264832016810722 4.970463066383005 0.02009623303270541 39.54994069939534 0.00012702125614450397 3.8961235967305528 -0.8999984733590637 RNT(ph)LQLHR ddPTM_A459_Selumetinib_30min_R1 1 RNTLQLHR 8 1 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 RNT(1)LQLHR 109.83 0.015330000000000003 2733000.0 459.82 671.07 488.49 790.65 615.89 323.47 370.36 261.93 168.74 273.26 True False 470.53291134603154 592.5008124280213 422.1557410835002 652.5778198386428 560.1828582442109 320.2161854872609 342.4234470214535 254.9827655314521 286.3394557180147 308.33558277780304 1.5260415522171935 1.9216102374243236 1.3691437662831143 2.1164531643073845 1.816796015553928 1.0385314033574238 1.1105544288354656 0.8269650983331406 0.9286617299838549 1.0 8.268357579819416 -6.78585176297854 6.595762490809099 0.9739274010741956 1.7596239054493998 0.7829832261971034 0.20247024757298937 0.0764331556194201 11.539909506586534 0.07015013172417811 0.06351621303362164 1.6373753086794272e-07 6.78585176297854 0.7856965043752042 RNT(ph)LQLHR ddPTM_A459_Selumetinib_30min_R2 3 RNTLQLHR 8 1 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 RNT(1)LQLHR;RNT(1)LQLHR;RNT(1)LQLHR 86.189 0.042710000000000005 55784600.0 86051.0 59834.3 111347.0 111174.0 79451.0 39505.0 52967.9 92744.0 58332.9 77871.0 True False 81268.62990944608 64423.39841240185 104183.05524544702 96031.90941415283 69469.65507904813 44946.455159315345 55431.012303902666 93013.86968540437 70001.10995740599 75622.66189684399 1.074659736525854 0.8519059868625238 1.3776697703072385 1.269882691317437 0.9186354108218366 0.594351666972875 0.7329947255693734 1.2299734940867795 0.9256631306220576 1.0 16.206531012235963 -6.372915268120751 6.936857168320238 0.8857959872679041 1.1386056543679486 0.26007862847935503 0.20059042625644022 0.3886244557224237 21.422336754559453 0.06822074109935534 0.07736194425563458 4.23725627856382e-07 6.372915268120751 0.2528096671000445 RNT(ph)YVCSER ddPTM_A459_Selumetinib_30min_R2 1 RNTYVCSER 9 1 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 RNT(0.999)Y(0.001)VCSER 85.845 0.043222 6168700.0 11225.0 8257.4 11701.0 9931.8 8629.2 7548.9 8091.7 7287.1 9238.3 8228.2 True False 10601.159437235274 8890.716028274197 10948.170399085535 8579.071706689374 7545.12274997321 8588.692452908634 8467.98008339937 7308.3042545556555 11086.218139669098 7990.630486568952 1.3266987448680336 1.1126426185290577 1.3701259766031932 1.073641400526467 0.9442462347189533 1.0748454039196198 1.0597386648816725 0.9146092122317276 1.3874021778761216 1.0 12.96409362560761 -5.860168897924375 8.023212100801114 1.0553158561513896 1.2534923566458447 0.31995638834739626 0.13593702045513412 0.2810016740606532 20.14973749253446 0.03648159956712169 0.054339122340450303 1.3798475349927988e-06 5.860168897924375 0.19817650049445512 RNVPQEESLEDS(ph)DVDADFK ddPTM_A459_Selumetinib_30min_R2 2 RNVPQEESLEDSDVDADFK 19 1 O00505 O00505 KPNA3 Importin subunit alpha-4 1 RNVPQEESLEDS(1)DVDADFK;RNVPQEESLEDS(1)DVDADFK 145.14 2.6902e-05 16032500.0 91080.0 92474.0 90027.0 99489.0 101587.0 89343.0 92004.0 85273.0 62236.0 90743.0 True False 86018.13822212825 99566.45844922474 84234.76083398613 85938.42657190221 88824.73286069713 101649.1872749958 96282.36830246732 85521.13031229487 74684.93901913175 88123.0138113713 0.976114348588343 1.1298576176973283 0.9558769859402672 0.9752097988370525 1.0079629488254664 1.1534919526535654 1.0925905065907215 0.9704744154047454 0.8475077711140933 1.0 16.427231215672762 -7.978887247034246 7.240857150064402 0.9186492456118701 1.041651444999462 0.31085022262880346 0.07195387024986263 0.17970948048178378 40.68149485588545 0.04197479006139578 0.01940036320722055 1.0498149496940582e-08 7.978887247034246 0.12300219938759194 RNVSSFPDDAT(ph)SPLQENR ddPTM_A459_Selumetinib_30min_R1 1 RNVSSFPDDATSPLQENR 18 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 RNVSSFPDDAT(0.967)S(0.033)PLQENR 121.14 0.0011707 9166500.0 1103.5 1035.0 1007.1 1016.8 979.35 763.17 1179.8 786.4 389.74 801.58 True False 1129.2094029627801 913.8217188415541 870.3413516043177 839.2349676999078 890.7679654182855 755.4932027029183 1090.8067361375706 765.5421174127969 661.3603145166469 904.4706010503954 1.2484755188851768 1.0103387747266732 0.9622660488837976 0.9278742357410765 0.984850103899235 0.83528773829192 1.2060167957596146 0.8463980106415225 0.7312126162515227 1.0 9.82092979996441 -4.382563968968868 1.4294610203620928 0.9359907929475947 1.7502325935436627 0.3857178045872217 0.11834566114585308 3.5883934125725636 3.13724167993582 0.033834010598794435 5.526589111120269 4.1441553862232484e-05 4.382563968968868 0.814241800596068 RNVSSFPDDATS(ph)PLQENR ddPTM_A459_Selumetinib_30min_R1 3 RNVSSFPDDATSPLQENR 18 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 RNVSSFPDDAT(0.129)S(0.871)PLQENR;RNVSSFPDDAT(0.26)S(0.74)PLQENR;RNVSSFPDDAT(0.034)S(0.966)PLQENR 209.19 1.2803e-29 12546400.0 1718.42 2014.08 2340.49 2501.24 2279.18 2197.2599999999998 2293.67 2227.6499999999996 1093.3600000000001 1751.0499999999997 True False 1758.4558425367477 1778.2705772796103 2022.6643133913108 2064.4453880898086 2073.028571421911 2175.1575593524553 2120.6566252556886 2168.5654855730104 1855.3520641451248 1975.8143241713801 0.8899904312993638 0.9000190734143928 1.0237117367997515 1.044857992390352 1.0492021168493657 1.1008916843766057 1.0733076480478765 1.0975553011452464 0.9390315888732232 1.0 10.948231661653812 -5.299529916026381 2.921667186321746 1.0510589978993576 0.887663590487552 0.625914652005645 0.04514238160222066 0.1560811403124788 2.6256140680746523 0.012099729267857249 0.034048654664650346 5.017300165773243e-06 5.299529916026381 -0.1633954074118057 RNVSSFPDDATS(ph)PLQENR ddPTM_A459_Selumetinib_30min_R2 3 RNVSSFPDDATSPLQENR 18 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 RNVSSFPDDAT(0.189)S(0.811)PLQENR;RNVSSFPDDAT(0.297)S(0.703)PLQENR;RNVSSFPDDAT(0.485)S(0.515)PLQENR 156.67 4.1078e-05 41144900.0 102560.0 119165.0 139962.0 158492.0 144384.0 118932.0 115296.0 122745.0 115217.0 148933.0 True False 96860.12578020933 128304.57232413316 130956.9972991032 136905.1161860501 126245.19111066285 135313.80344279678 120657.49245468987 123102.1676284712 138263.61943195743 144632.91731559415 0.6696962736972047 0.8871049184755642 0.9054439316421337 0.9465695550295669 0.8728662427183943 0.9355671305968147 0.8342325847677603 0.8511352043038578 0.9559623217048254 1.0 17.142036410151995 -4.759906719633024 4.577799174458275 0.9047644110334722 0.6503247749301633 0.6909302922703451 0.04822621781690991 0.11429245365184323 5.412827204253455 0.011678207889723312 0.09603062048257065 1.7381741240955797e-05 4.759906719633024 -0.2544396361033089 RPAAAAAAGSAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 5 RPAAAAAAGSASPR 14 1 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 RPAAAAAAGS(0.006)AS(0.994)PR;RPAAAAAAGS(0.003)AS(0.997)PR;RPAAAAAAGS(0.016)AS(0.984)PR;RPAAAAAAGSAS(1)PR;RPAAAAAAGS(0.033)AS(0.967)PR 160.45 0.00014921 278911400.0 6581.3099999999995 7979.910000000001 7453.139999999999 8271.44 8279.61 6538.1 7373.589999999999 7077.139999999999 4758.38 6565.92 True False 6734.641717999975 7045.618427440486 6441.044525167516 6826.988278158657 7530.720737383874 6472.332650119825 6817.394169788635 6889.431257409463 8074.623321675276 7408.719789476804 0.9090155802039813 0.9509899993043252 0.8693869802332443 0.9214801574565653 1.016467210445772 0.8736101288798904 0.9201851822594133 0.9299084663986175 1.0898810524787708 1.0 12.855008554192027 -8.244138848394478 22.45213414686409 1.0449404738789416 0.9241749952576053 0.5508303778927133 0.04372710173173715 134.8405052918141 174994.15881255892 0.029095462095176078 0.010912597383582924 5.6998201405899225e-09 8.244138848394478 -0.12076547862133635 RPAAAAAAGSAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 RPAAAAAAGSASPR 14 1 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 RPAAAAAAGS(0.006)AS(0.994)PR;RPAAAAAAGS(0.151)AS(0.849)PR;RPAAAAAAGS(0.025)AS(0.975)PR 141.85 0.00028282 216626000.0 8001.0 6889.9 7948.8 7959.400000000001 8089.0 6337.45 6261.700000000001 9749.7 5217.83 9042.2 True False 7556.336450540711 7418.333175479733 7437.382861999066 6875.315989269153 7072.7875034224835 7210.3762118568 6552.881457323161 9778.07001285028 6261.541798351384 8781.128191542963 0.860520002181287 0.8448041087276544 0.8469734981391062 0.78296499485006 0.8054531660560691 0.8211218484204635 0.7462459622937963 1.11353231607158 0.7130680320077581 1.0 13.100190592507127 RPAEAT(ph)SSPT(ph)SPERPR ddPTM_A459_Selumetinib_30min_R1 1 RPAEATSSPTSPERPR 16 2 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 2 RPAEAT(0.685)S(0.323)S(0.341)PT(0.572)S(0.08)PERPR 93.181 0.021027 5003100.0 1346.7 1321.6 1505.9 1599.9 1376.4 1006.3 1445.1 1114.5 781.78 1014.1 True False 1378.0754897779573 1166.8664576048284 1301.4070513165948 1320.5074988425272 1251.9048630231566 996.177535647295 1336.0949435433156 1084.9398395937974 1326.6235610479403 1144.269613170496 1.2043276111821595 1.0197478323065154 1.137325536165125 1.1540177975920538 1.0940645881126119 0.8705793845972424 1.1676399758980907 0.948150529478529 1.1593627461382858 1.0 10.160211305096453 -6.537660615806891 24.987446871062428 1.0287573616506436 1.1219632928922552 0.2035624116675826 0.0933735710812469 389.16050120978616 657836.6460520788 0.028882990552646304 0.028892500702622358 2.8996086335791456e-07 6.537660615806891 0.09320593124161158 RPAEATSSPT(ph)SPERPR ddPTM_A459_Selumetinib_30min_R1 2 RPAEATSSPTSPERPR 16 2 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 1 RPAEATSSPT(0.979)S(0.021)PERPR;RPAEATSSPT(0.982)S(0.018)PERPR 169.43 3.6954e-05 325450000.0 2225.9 2412.77 2524.4 2545.8999999999996 2594.8999999999996 2309.1 2531.1000000000004 2188.8999999999996 1197.99 1820.94 True False 2277.7591391525616 2130.2817667336576 2181.600345536631 2101.3063574618345 2360.191753166804 2285.872550495052 2340.1770891996985 2130.8432614507497 2032.9015322722776 2054.675386457632 1.1085737212628695 1.0367972385196937 1.0617737283054838 1.022695055049351 1.148693252823697 1.1125224770595106 1.1389522182549168 1.0370705151262043 0.9894027765510474 1.0 11.004694768427871 -7.982960456679034 6.965182663563025 1.0003517444153105 1.0875962035649167 0.498426213307419 0.038753128393804445 0.1356427716582175 29.931925578681728 0.02417678309038891 0.011042359306796883 1.040014856806677e-08 7.982960456679034 0.08724445914960621 RPAEATSSPTS(ph)PERPR ddPTM_A459_Selumetinib_30min_R1 1 RPAEATSSPTSPERPR 16 2 Q9BU76 Q9BU76 MMTAG2 Multiple myeloma tumor-associated protein 2 1 RPAEATSSPT(0.04)S(0.96)PERPR 78.917 0.028805 3138900.0 405.68 390.94 408.48 343.52 333.26 368.98 265.68 429.46 262.43 295.0 True False 415.13155468413265 345.1685630569248 353.0106596200295 283.53068066903234 303.1166918418318 365.26839620703487 245.63954369980502 418.0693257173187 445.3245428711542 332.86612354333556 1.247142695883521 1.0369591215309948 1.0605184326426997 0.8517859301837897 0.910626436283683 1.0973432571593031 0.7379529676525506 1.2559683793201941 1.3378487967796393 1.0 8.378798241740073 -10.838955758033034 4.659798704373329 0.9999701754590206 1.0458703699141987 0.004627037036103343 0.17989424022697056 5.751647645395603e-05 8.44153047100108e-06 0.179729374528023 0.043562455788856085 1.4489194487458344e-11 10.838955758033034 0.04590019445517812 RPAEDMEEEQAFK ddPTM_A459_Selumetinib_30min_R1 1 RPAEDMEEEQAFK 13 1 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 112.84 0.02371 16800000.0 5336.3 8108.3 4822.5 5092.5 5482.7 5390.4 6274.0 5589.6 2866.4 5864.8 False True 5460.625407367726 7158.976466553593 4167.630988096336 4203.190473064299 4986.790753049307 5336.1774700916085 5800.747128773618 5441.345650420359 4864.07144642715 6617.604207989674 0.8251665158177509 1.0818078932418322 0.6297794272834576 0.6351528953619853 0.7535643710798801 0.8063609279698304 0.8765630198569695 0.822253111458498 0.7350200002222222 1.0 12.692093292806064 -9.398778168828889 11.812139178998317 0.9999999999731436 0.7971319480311032 0.20071013311441877 0.1220049098987384 0.0 0.0 0.1252859947344432 0.030386317041216915 3.992287704178109e-10 9.398778168828889 -0.20286805194204038 RPAEDMEEEQAFK ddPTM_A459_Selumetinib_30min_R2 2 RPAEDMEEEQAFK 13 1 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 183.89 0.00016475 11246500.0 65530.0 62270.0 71981.0 75404.0 80485.0 57279.0 70746.0 75417.0 65765.0 67535.0 False True 61888.104937374395 67045.90877039189 67349.82082698708 65133.84512084463 70373.75475497077 65168.66232300782 74035.82918053956 75636.45098404364 78919.83762763049 65585.08907299722 0.9436307217406076 1.0222736557660044 1.0269075147862603 0.9931197173240042 1.0730145487283502 0.9936505880242702 1.1288515457856059 1.1532568157353433 1.203319820756689 1.0 16.001080231501803 -7.269099369176439 22.69457327588279 1.134128488233468 1.0124138920738646 0.4766049195081088 0.05710236696179149 134.254554573119 397756.50850064494 0.022483238829339492 0.01553271468449451 5.38146637257565e-08 7.269099369176439 -0.12171459615960334 RPAEDMEEEQAFKR ddPTM_A459_Selumetinib_30min_R1 1 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 115.57 0.0017613 13727000.0 1359.0 1646.7 1596.1 2037.3 1762.7 1663.0 1567.3 1598.9 731.29 1214.5 False True 1390.6620558463233 1453.9035984699383 1379.3583867497284 1681.5237998574173 1603.2640962299608 1646.2717298831885 1449.07729915953 1556.491978040844 1240.9457186916366 1370.392905231799 1.0147907585752538 1.060939233499617 1.0065422708215297 1.22703773015593 1.169930236875221 1.2013136696768911 1.0574173973225742 1.1357997929634398 0.9055400928843347 1.0 10.420373872126733 -8.256385994358553 24.989158349904375 0.9527700402049677 1.1114831298494607 0.4124511151311292 0.07465312233618733 390.5386229450141 1931250.5521525824 0.05744922899411371 0.020210266662012612 5.541329890187177e-09 8.256385994358553 0.15871308964449304 RPAPAVS(ph)PGSWKPGPPGSPR ddPTM_A459_Selumetinib_30min_R2 1 RPAPAVSPGSWKPGPPGSPR 20 2 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 RPAPAVS(0.779)PGS(0.22)WKPGPPGSPR 45.342 0.042008 7422400.0 28970.0 21867.0 33158.0 29896.0 28540.0 22943.0 30904.0 25666.0 28373.0 26408.0 True False 27359.963376098513 23544.128586512936 31024.650379700724 25824.113226523437 24954.550049162783 26103.189994182314 32341.09723511426 25740.683810764964 34048.39280785763 25645.532423775912 1.066851057096134 0.9180596525531765 1.2097487338940114 1.0069634273836312 0.9730564231151418 1.0178455086384601 1.2610811388392509 1.003710251961891 1.3276539650349175 1.0 14.646419902791669 -7.217983333559123 24.908219645672936 1.1484206284555074 1.0311546363809927 0.18980326077042908 0.11742447750889758 721.1094425150668 413327.20933039195 0.042249067219325497 0.032725841836254224 6.053641056995216e-08 7.217983333559123 -0.11726599207451471 RPAS(ph)MAVMEGDLVK ddPTM_A459_Selumetinib_30min_R2 1 RPASMAVMEGDLVK 14 1 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-2 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 RPAS(1)MAVMEGDLVK 95.5 0.006394 2263400.0 17262.0 13859.0 15015.0 21663.0 20148.0 19968.0 19686.0 24034.0 16375.0 15968.0 True False 16302.647145261051 14921.940736291337 14048.95124709592 18712.462029240596 17616.828114594653 22718.41074854345 20601.438007068977 24103.934960957107 19650.457555727935 15506.962350153502 1.0513114546318398 0.9622736161569145 0.9059770011601821 1.2067135785014247 1.1360592562746672 1.4650458442828787 1.3285282792258177 1.5543943692310895 1.2672022483844758 1.0 13.920628484906393 -6.209139455398648 1.5694633346499218 1.351596565709481 0.9768444946630875 0.4495476035177063 0.1528770148309034 0.29967274681563827 1.4691957682735923 0.05266597735847715 0.07478870507679203 6.17817982034883e-07 6.209139455398648 -0.3747520710463935 RPAS(ph)PALLLPPCMLK ddPTM_A459_Selumetinib_30min_R1 2 RPASPALLLPPCMLK 15 1 Q9HAW0-2;Q9HAW0 Q9HAW0-2 BRF2 Transcription factor IIIB 50 kDa subunit 1 RPAS(1)PALLLPPCMLK;RPAS(1)PALLLPPCMLK 110.26 0.0018196 20138500.0 9694.9 11502.099999999999 12425.5 12858.5 11600.0 9883.900000000001 10688.8 11179.3 5808.5 9164.2 True False 9920.772307008483 10155.428784818774 10738.185348385914 10613.004358939086 10550.782048146335 9784.476939863174 9882.535210397746 10882.788648515865 9856.600263945053 10340.514336867242 0.9594080123884898 0.9821009336654969 1.0384575658969737 1.026351689402947 1.0203343571150443 0.9462272978993302 0.9557102179301997 1.0524417155648866 0.9532021273645083 1.0 13.33602032659428 RPAS(ph)PSHNGSSGGGYGASK ddPTM_A459_Selumetinib_30min_R1 2 RPASPSHNGSSGGGYGASK 19 1 K7ELX9;K7EQ79;K7ENM4;K7ENP7;Q6PI98;Q6PI98-3;Q6PI98-4 K7ELX9 INO80C INO80 complex subunit C 1 RPAS(0.97)PS(0.029)HNGS(0.001)SGGGYGASK;RPAS(0.735)PS(0.215)HNGS(0.038)S(0.012)GGGYGASK 72.532 0.0064786 4828500.0 1020.9300000000001 982.24 894.11 1177.46 1127.02 777.75 1227.51 962.01 396.73 727.0899999999999 True False 1044.7156826160324 867.2388841690125 772.6947729946744 971.8387146616184 1025.0812399915424 769.926541140499 1134.9179324260294 936.4943697511251 673.2218339872467 820.4190839563514 1.2733927123904083 1.0570681510562618 0.9418293505173801 1.1845637597495513 1.2494605013918467 0.9384551824753278 1.3833392647975145 1.1414829177729722 0.8205828547292349 1.0 9.680217240842817 -8.246272371273417 23.562306049956074 0.9102914564511846 1.142116416334541 0.3146397151750753 0.13916470167559972 396.31460307111826 615688.8977884036 0.09417259658231353 0.035226547404140045 5.671887768416873e-09 8.246272371273417 0.23182495988335639 RPAS(ph)PSHNGSSGGGYGASK ddPTM_A459_Selumetinib_30min_R2 2 RPASPSHNGSSGGGYGASK 19 1 K7ELX9;K7EQ79;K7ENM4;K7ENP7;Q6PI98;Q6PI98-3;Q6PI98-4 K7ELX9 INO80C INO80 complex subunit C 1 RPAS(0.999)PS(0.001)HNGSSGGGYGASK;RPAS(0.965)PS(0.035)HNGSSGGGY(0.001)GASK 98.175 0.00075855 10674200.0 3644.7 1833.13 5937.6 7820.099999999999 6803.5 4199.0 5710.4 6304.299999999999 5267.6 6200.2 True False 3442.1421648901023 1973.7251765580306 5555.581280370075 6754.988889575058 5948.783505938293 4777.374135273133 5975.944914942934 6322.644469266948 6321.267189041374 6021.184115945754 0.5716719666110793 0.32779684835264594 0.9226725463613321 1.1218705091056738 0.9879756857433203 0.7934276785560055 0.9924866604090359 1.0500666226968287 1.0498378835984965 1.0 12.555831517529834 -5.331036629552649 5.6288109765768555 0.9928241037874187 0.45126865417143314 0.8308353399690968 0.09769992354676778 0.07474737520591829 4.434432884173031 0.026401625836064382 0.05686674941978132 4.6662002267974265e-06 5.331036629552649 -0.5415554496159856 RPAS(ph)PSS(ph)PEHLPATPAESPAQR ddPTM_A459_Selumetinib_30min_R1 1 RPASPSSPEHLPATPAESPAQR 22 1 Q9H7L9 Q9H7L9 SUDS3 Sin3 histone deacetylase corepressor complex component SDS3 2 RPAS(0.976)PS(0.332)S(0.691)PEHLPAT(0.001)PAESPAQR 62.364 0.027225 12417000.0 668.19 754.45 892.21 985.06 793.82 890.73 827.66 764.28 209.3 714.88 True False 683.7575269285909 666.1186432657108 771.0527825587213 813.0377628663164 722.0191211603043 881.7700649181312 765.2289398471108 744.0088116686825 355.1668133328224 806.6418115208805 0.8476594160664721 0.8257923575890261 0.9558800096227866 1.0079291096172867 0.8950926059721295 1.0931370681809816 0.9486601474380706 0.9223533928471835 0.4403030047043732 1.0 9.65578437819946 -8.041762003360796 24.978210024397562 0.7072102054650883 0.9418320988848612 0.2644657977832825 0.1445647218911557 575.1556087378203 344002.1170439581 0.09140679832705254 0.034556362232021486 9.083181589894456e-09 8.041762003360796 0.2346218934197729 RPAS(ph)PSS(ph)PEHLPATPAESPAQR ddPTM_A459_Selumetinib_30min_R2 1 RPASPSSPEHLPATPAESPAQR 22 1 Q9H7L9 Q9H7L9 SUDS3 Sin3 histone deacetylase corepressor complex component SDS3 2 RPAS(0.832)PS(0.384)S(0.785)PEHLPATPAESPAQR 90.166 0.0010241 12467000.0 7899.1 6761.9 12238.0 15312.0 11390.0 5186.8 6518.0 8607.0 7624.3 10324.0 True False 7460.099644602684 7280.5159870646075 11450.620403726922 13226.47918532669 9959.08637210806 5901.234618917527 6821.099915171978 8632.04494503444 9149.37304074116 10025.9192950266 0.7440813580359955 0.7261694187660316 1.1421017930402702 1.3192285710785385 0.9933339855476702 0.5885978577390762 0.6803465811415033 0.8609729134081902 0.912571981831107 1.0 13.291446905663102 -6.588342463919959 24.3387635591005 0.7917052444893503 0.9984738178507074 0.1663164695052075 0.1946341856273088 82.43552281976586 30647.27722791984 0.07104676670087176 0.07104677180455321 2.580224746010969e-07 6.588342463919959 0.20676857336135712 RPAS(ph)PSSPEHLPATPAESPAQR ddPTM_A459_Selumetinib_30min_R2 3 RPASPSSPEHLPATPAESPAQR 22 1 Q9H7L9 Q9H7L9 SUDS3 Sin3 histone deacetylase corepressor complex component SDS3 1 RPAS(0.979)PS(0.016)S(0.006)PEHLPATPAESPAQR;RPAS(0.337)PS(0.331)S(0.331)PEHLPATPAESPAQR;RPAS(0.419)PS(0.419)S(0.162)PEHLPATPAESPAQR 101.05 6.3926e-05 27578500.0 33419.9 35230.9 47244.2 58787.0 70734.0 43423.7 36106.6 42278.3 42916.2 51611.0 True False 31562.555748459603 37932.99674480168 44204.559607595664 50780.109186768546 61847.76255001685 49404.92051389856 37785.6284438706 42401.322853450656 51500.6391788172 50120.856328517846 0.6297289803187398 0.7568305795928412 0.8819593846892053 1.0131532640609653 1.233972583082676 0.9857158104018281 0.7538903205524697 0.8459816124355617 1.027529115649093 1.0 15.61312344325855 -5.190339114278541 2.01007416683185 0.9732403933267649 0.6367217865608242 0.48732735172295105 0.11861390372823571 0.38864580312772246 2.7387817548695987 0.03776905282134814 0.17445395030422303 6.4515027350031885e-06 5.190339114278541 -0.3365186067659407 RPAS(ph)TAGLPTAGLPTATGLPSGAPPGVATIR ddPTM_A459_Selumetinib_30min_R1 2 RPASTAGLPTAGLPTATGLPSGAPPGVATIR 31 1 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 RPAS(0.468)T(0.468)AGLPT(0.065)AGLPTATGLPSGAPPGVATIR;RPAS(0.486)T(0.486)AGLPT(0.027)AGLPTATGLPSGAPPGVATIR 78.311 1.1072e-05 30816000.0 1164.58 1640.03 1506.3899999999999 1620.46 1453.56 1239.35 1319.94 1144.85 700.54 940.94 True False 1191.7124481217897 1448.0145251707374 1301.830512007972 1337.4770808015262 1322.0857546468621 1226.8832642397656 1220.3758631102087 1114.484859003103 1188.765214582778 1061.7188145317498 1.1224369690080054 1.3638399408127244 1.2261537557682998 1.2597281525913189 1.2452315401700234 1.1555632691513131 1.1494341499904863 1.0496986996454656 1.1196610612076792 1.0 10.052186018229776 -7.395423532278666 0.8121980305855793 1.0337585930709159 1.2578952364768983 0.6225394599040637 0.062422548649481616 0.3909310860825892 0.49054474592313757 0.04937826318298149 0.027040683089841224 4.023244884174028e-08 7.395423532278666 0.22413664340598238 RPAS(ph)TAGLPTAGLPTATGLPSGAPPGVATIR ddPTM_A459_Selumetinib_30min_R2 2 RPASTAGLPTAGLPTATGLPSGAPPGVATIR 31 1 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 RPAS(0.499)T(0.499)AGLPT(0.003)AGLPTATGLPSGAPPGVATIR;RPAS(0.698)T(0.287)AGLPT(0.015)AGLPTATGLPSGAPPGVATIR 115.06 4.8105e-16 9161500.0 22661.1 22113.6 28484.0 32648.0 32984.0 30544.0 26261.0 29523.0 25856.0 25584.0 True False 21401.6867815708 23809.642013568944 26651.370451034298 28201.286079058642 28840.255039298714 34751.15874917423 27482.18853518431 29608.90704220423 31027.92247700164 24845.323444785034 0.8613969880139739 0.9583148340363636 1.0726916278736693 1.1350742179602422 1.1607920944716945 1.39870019508514 1.106131244226275 1.1917295867773885 1.2488435719485196 1.0 14.600686703049465 -5.2840310365947465 1.1763146072574502 1.1984870783874044 0.83194374891565 0.5584844085817081 0.09645501669151668 0.5386318063413102 1.0911675304601391 0.030826252664490933 0.1958614042259558 5.199588366592329e-06 5.2840310365947465 -0.3665433294717544 RPAS(ph)VSSSAAVEHEQR ddPTM_A459_Selumetinib_30min_R1 3 RPASVSSSAAVEHEQR 16 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 RPAS(0.914)VS(0.067)S(0.015)S(0.005)AAVEHEQR;RPAS(0.672)VS(0.325)S(0.003)SAAVEHEQR;RPAS(0.852)VS(0.127)S(0.02)S(0.001)AAVEHEQR 164.74 1.1478e-05 70284000.0 3977.12 3895.05 4341.599999999999 4370.110000000001 4285.0599999999995 3440.21 3352.88 3609.8999999999996 2548.2299999999996 2981.0 True False 4069.7791578716196 3439.0157352403817 3752.0345667017236 3606.9523256245516 3897.477079588789 3405.6046108607597 3099.9695621808237 3514.1537253922334 4324.160194644519 3363.640387398925 1.2099328968453567 1.0224088603894257 1.115468401663217 1.072335895102561 1.158708015931119 1.0124758352941188 0.9216114700590821 1.0447471550636538 1.2855596010928967 1.0 11.715807757482038 -6.770552053535815 24.99431717648096 1.0474713066572803 1.1081541900052259 0.0882825470953047 0.09880064733677192 564.2290392903196 1547560.8132142727 0.03531866678865105 0.031573395784535094 1.6960863010811243e-07 6.770552053535815 0.06068288334794558 RPAS(ph)VSSSAAVEHEQR ddPTM_A459_Selumetinib_30min_R2 2 RPASVSSSAAVEHEQR 16 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 RPAS(0.947)VS(0.042)S(0.01)S(0.001)AAVEHEQR;RPAS(0.959)VS(0.038)S(0.002)SAAVEHEQR 90.01700000000002 0.0065191 84698000.0 62801.0 75322.0 66001.0 60229.0 52877.0 49392.0 53924.0 43520.0 44140.0 65083.0 True False 59310.77183232181 81098.95520159727 61754.56751645539 52025.706299179845 46234.118533622255 56195.29966406542 56431.57284837892 43646.63599487618 52969.23337464615 63203.88468405812 0.938403899203394 1.2831324467948855 0.9770691758133613 0.8231409597565806 0.7315075452202998 0.8891114833363958 0.8928497533097459 0.6905688821669081 0.8380692680430536 1.0 15.947725612670043 -5.56929877349099 4.046430207179154 0.8262198941565674 1.1165787043901714 0.48455223497892097 0.11259659534075053 0.15021502045143487 5.2057374546203645 0.029491993135596806 0.055739998286927425 2.6958841571046504e-06 5.56929877349099 0.290358810233604 RPASPS(ph)S(ph)PEHLPATPAESPAQR ddPTM_A459_Selumetinib_30min_R2 1 RPASPSSPEHLPATPAESPAQR 22 1 Q9H7L9 Q9H7L9 SUDS3 Sin3 histone deacetylase corepressor complex component SDS3 2 RPAS(0.614)PS(0.717)S(0.669)PEHLPATPAESPAQR 75.868 0.004336 12240000.0 9344.1 7038.9 10109.0 13509.0 10266.0 7317.2 7240.3 9990.7 8923.3 9518.8 True False 8824.792329396 7578.7609963692275 9458.597945846992 11669.05089567518 8976.29330079555 8325.077881071818 7576.988296382273 10019.771282950584 10708.209337833712 9243.967511187446 0.9546541913648936 0.8198601939261563 1.0232184323884512 1.2623422660835615 0.971043363137317 0.9005957529595872 0.8196684256205224 1.0839254109043792 1.158399715801054 1.0 13.174296473986116 -5.2828309982857675 22.39067304646354 1.024827019050553 0.8872572352565286 0.17502231972466376 0.12160082295626928 354.1140117112745 370652.623765057 0.034747537269636135 0.07251087658994806 5.213975687139767e-06 5.2828309982857675 -0.1375697837940245 RPASPS(ph)SPEHLPATPAESPAQR ddPTM_A459_Selumetinib_30min_R1 1 RPASPSSPEHLPATPAESPAQR 22 1 Q9H7L9 Q9H7L9 SUDS3 Sin3 histone deacetylase corepressor complex component SDS3 1 RPAS(0.258)PS(0.371)S(0.371)PEHLPATPAESPAQR 70.50399999999998 0.0020797 8178600.0 992.68 1553.6 1766.4 1561.6 1667.8 1312.4 1565.1 1424.4 684.79 1084.3 True False 1015.8075125809628 1371.7037897509547 1526.5325821406682 1288.8958748624852 1516.947784474005 1299.198447563858 1447.0432469307611 1386.6202848967284 1162.0386149172643 1223.4804669764023 0.8302605068075476 1.1211489081970045 1.2476967334944065 1.0534666548847686 1.239862691247414 1.0618873636573685 1.1827268893853706 1.1333407621320633 0.9497810927779012 1.0 10.25677535345068 -10.366360576998185 8.34562190317346 0.999999958562595 1.102960137658291 0.03996911402383163 0.12217734070172395 8.27883177647446e-11 0.0 0.11518747293745404 0.027937065745241112 4.301693101499851e-11 10.366360576998185 0.10296017909569588 RPASVSS(ph)SAAVEHEQR ddPTM_A459_Selumetinib_30min_R1 1 RPASVSSSAAVEHEQR 16 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 RPAS(0.076)VS(0.127)S(0.67)S(0.127)AAVEHEQR 124.45 0.00066027 15209000.0 1731.6 1515.7 1855.1 2036.3 1716.7 1351.4 1663.1 1484.1 744.37 1072.6 True False 1771.942910892932 1338.2411393701864 1603.1876093348928 1680.6984310850912 1561.4247881080014 1337.806142973026 1537.6510280305083 1444.7368469637981 1263.141523366236 1210.2786580087507 1.4640784576076697 1.1057297676982671 1.3246433775611546 1.3886871589145542 1.2901365960439104 1.10537034931616 1.2704933841933372 1.1937224848208075 1.043678259554258 1.0 10.241123540627106 -8.029878268247462 0.5683386490323487 0.989144877124372 1.309435774388684 0.5113473461659529 0.10197509216212627 0.6861775757629187 0.5127899354910487 0.10248246110295399 0.054812733599968855 9.335159265133404e-09 8.029878268247462 0.3202908972643119 RPATADS(ph)PKPSAK ddPTM_A459_Selumetinib_30min_R2 1 RPATADSPKPSAK 13 2 Q03111 Q03111 MLLT1 Protein ENL 1 RPAT(0.002)ADS(0.997)PKPS(0.001)AK 85.006 0.032081 34272000.0 137880.0 122070.0 112320.0 119890.0 100300.0 84846.0 120140.0 95620.0 73843.0 112550.0 True False 130217.18157737183 131432.37648308542 105093.45348476955 103560.7751782145 87699.41730662317 96532.76634469745 125726.74805289358 95898.23836925685 88613.66334580867 109300.38905998121 1.1913697901469684 1.2024877277514423 0.9615103330244963 0.9474877085879634 0.8023705867917452 0.8831877651572015 1.150286372575472 0.8773824063574961 0.8107351136433723 1.0 16.737939010798016 -5.305127369857341 3.7466264080386025 0.9238892378836263 1.2025020880508706 0.5637674086448787 0.09456810449112987 0.16339205421772016 4.8176683828726565 0.026456798694692397 0.0653859860240903 4.953049065106549e-06 5.305127369857341 0.27861285016724424 RPDDVPLSLS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 RPDDVPLSLSPSK 13 1 F8WDB4;Q9UFC0 F8WDB4 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 RPDDVPLS(0.006)LS(0.992)PS(0.002)K;RPDDVPLSLS(1)PSK;RPDDVPLS(0.01)LS(0.809)PS(0.182)K 130.77 0.00081691 19690300.0 9873.6 11285.6 11456.2 12048.2 9474.2 10913.900000000001 9173.7 9276.3 6315.299999999999 8566.400000000001 True False 10103.635669318812 9964.276705466902 9900.510964402138 9944.20804272426 8617.260282805863 10804.116075028338 8481.720423211762 9030.262390331029 10716.602848737564 9665.980883802129 1.04527784513314 1.0308603777775565 1.024263453799399 1.0287841619248774 0.8915039649257251 1.117746476525052 0.8774816053511026 0.9342313520879798 1.108692741850548 1.0 13.238700426244284 -6.045461526404863 24.972760168938446 0.9835779999613258 1.0320929773903946 0.07441852677892491 0.07505357209453811 1102.3339522725723 605527.6854703982 0.021560730728283566 0.02783583548083478 9.006135434237648e-07 6.045461526404863 0.04851497742906885 RPDDVPLSLS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 RPDDVPLSLSPSK 13 1 F8WDB4;Q9UFC0 F8WDB4 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 RPDDVPLS(0.006)LS(0.94)PS(0.054)K;RPDDVPLSLS(0.915)PS(0.085)K;RPDDVPLS(0.019)LS(0.975)PS(0.007)K 176.68 5.2314e-05 22715800.0 109031.0 92116.0 108391.0 116138.0 112329.0 99900.0 112953.0 120523.0 95481.0 101000.0 True False 102971.49350567479 99181.00100037603 101417.24106719748 100319.80405077533 98217.2267859988 113660.31819809144 118205.53831212342 120873.70197634315 114579.86796204346 98083.86757048478 1.04983108900837 1.0111856664818282 1.033984931256073 1.0227961696013237 1.001359644749104 1.1588074676644775 1.205147607247225 1.2323504870918878 1.1681826053576483 1.0 16.581728246983012 -6.791531637290289 7.645691083239499 1.1712311285400276 1.0236132578547017 0.5276220423784352 0.05983013998475264 0.13553237917190386 27.104654094436015 0.019937297580761605 0.017859429527525658 1.6161004928520655e-07 6.791531637290289 -0.14761787068532595 RPDDVPLSLS(ph)PSKR ddPTM_A459_Selumetinib_30min_R2 2 RPDDVPLSLSPSKR 14 2 F8WDB4;Q9UFC0 F8WDB4 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 RPDDVPLS(0.014)LS(0.761)PS(0.225)KR;RPDDVPLS(0.029)LS(0.726)PS(0.245)KR 96.805 0.013044 178690000.0 71337.0 75621.0 62910.0 71635.0 74327.0 60939.0 55133.0 60955.0 47713.0 60278.0 True False 67372.37512463717 81420.88754016053 58862.43909122906 61878.18942273238 64989.377768189224 69332.79410083577 57696.79374396698 61132.3689583565 57256.933212607444 58537.617518947496 1.1509244479044614 1.3909156366639992 1.0055489373508655 1.0570670971141523 1.1102156275347799 1.1844143482333234 0.9856361804491213 1.044326222169345 0.9781220288658738 1.0 15.837076408802341 -2.5403012740642255 0.2491843429619569 0.9853890776079892 2.0609750572905567 0.3667516494134364 0.09595230627341435 32.39957264837242 0.685768683710754 0.12815896834264232 13.150997308764893 0.0028820315178129307 2.5403012740642255 1.0755859796825675 RPDDVPLSLSPS(ph)KR ddPTM_A459_Selumetinib_30min_R1 2 RPDDVPLSLSPSKR 14 2 F8WDB4;Q9UFC0 F8WDB4 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 RPDDVPLSLS(0.26)PS(0.74)KR;RPDDVPLS(0.002)LS(0.17)PS(0.829)KR 127.88 0.0013339 202691000.0 4890.0 5482.0 6137.8 6626.4 5496.3 5361.0 5445.6 4817.4 2941.8999999999996 4107.2 True False 5003.927485716355 4840.164891487339 5304.320472522076 5469.2236329333855 4999.1606354505775 5307.073207398541 5034.8340077222865 4689.626902879456 4992.189432125322 4634.399127515889 1.0797359804438205 1.0443996639714854 1.1445540892299615 1.1801365144535956 1.0787074004414046 1.1451480680394517 1.0864049187798457 1.0119169225273805 1.0772031701985096 1.0 12.178166583178925 -7.594423348685062 5.060940539043145 1.0342664110953523 1.112419752975336 0.4411082632249951 0.04132743494457572 0.21120976033289618 10.072434139960102 0.02093423048725522 0.011837011824206111 2.544348821337926e-08 7.594423348685062 0.07815334187998357 RPDHS(ph)GGSPSPPTSEPAR ddPTM_A459_Selumetinib_30min_R2 1 RPDHSGGSPSPPTSEPAR 18 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 RPDHS(0.606)GGS(0.393)PS(0.001)PPTSEPAR 74.742 0.0082223 999880.0 909.82 2159.9 2281.0 2808.2 2808.9 1783.7 2315.0 1150.8 1164.1 2218.4 True False 859.255846698031 2325.557384826876 2134.242943365022 2425.718315584798 2456.0208701153915 2029.3884841835416 2422.652087085476 1154.1486374748047 1396.9525276716272 2154.349027904593 0.39884709281939235 1.0794710396062457 0.9906672111718465 1.1259634739613893 1.1400292331016653 0.9419961472804649 1.124540200174456 0.5357296438624786 0.6484337076199578 1.0 11.07303628572125 -7.758881487868441 24.999998591786547 0.6940612553729426 0.9877950118853227 0.18121813626159222 0.2321819191096651 93.41976261937542 913084.6794793189 0.11269927395143033 0.06119289575976173 1.7422822499427678e-08 7.758881487868441 0.2937337565123801 RPDHSGGS(ph)PSPPTSEPAR ddPTM_A459_Selumetinib_30min_R1 7 RPDHSGGSPSPPTSEPAR 18 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 RPDHS(0.015)GGS(0.813)PS(0.172)PPTSEPAR;RPDHS(0.001)GGS(0.935)PS(0.064)PPTSEPAR;RPDHS(0.001)GGS(0.93)PS(0.069)PPTSEPAR;RPDHS(0.256)GGS(0.734)PS(0.01)PPTSEPAR;RPDHS(0.043)GGS(0.876)PS(0.081)PPT(0.001)S(0.001)EPAR;RPDHS(0.005)GGS(0.963)PS(0.032)PPT(0.001)S(0.001)EPAR;RPDHS(0.041)GGS(0.921)PS(0.038)PPTSEPAR 131.35 0.00027567 125308000.0 6652.51 7367.570000000001 7977.030000000001 8416.74 7814.86 7372.699999999999 7785.580000000001 7094.59 3420.27 5762.58 True False 6807.500539468892 6504.9714793096355 6893.793140689299 6946.914360777455 7108.007292825597 7298.537331876001 7198.307432393584 6906.4184267238725 5803.948383362888 6502.2632752825575 1.0469432336501432 1.0004165017490714 1.0602143974845017 1.0683840482413525 1.0931589497222745 1.122461060538777 1.1070464433141212 1.0621560730980633 0.8926043344670131 1.0 12.666726256294 -8.19494308767298 7.820484877145975 0.9467792335952365 1.0714055041295263 0.6057883903262706 0.03994788224844016 0.19054364779697727 20.295394882921034 0.029352308988452216 0.010956809648930171 6.383471332134466e-09 8.19494308767298 0.12462627053428976 RPDHSGGS(ph)PSPPTSEPAR ddPTM_A459_Selumetinib_30min_R2 3 RPDHSGGSPSPPTSEPAR 18 1 Q8TAD8 Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 1 RPDHS(0.17)GGS(0.787)PS(0.042)PPTSEPAR;RPDHS(0.053)GGS(0.932)PS(0.015)PPTSEPAR;RPDHS(0.186)GGS(0.782)PS(0.032)PPTSEPAR 79.029 0.006386 20899600.0 16137.0 12754.9 18805.3 23107.199999999997 25058.4 14674.899999999998 13584.8 17025.2 18392.5 17877.5 True False 15240.170141529235 13733.159816532383 17595.387471662525 19959.959497856646 21910.339767061672 16696.234269521246 14216.520117770528 17074.74051332641 22071.513929387853 17361.33012367669 0.877822726309737 0.7910200266167192 1.0134815331727745 1.1496791637315882 1.2620196500486576 0.9616909620739017 0.8188612287478253 0.9834926466861292 1.2713031646859594 1.0 14.083589862430943 -5.360589284064724 4.837504176564486 1.0583018243321836 0.8355956651409532 0.3163688882160851 0.1323745764892547 0.2757116448510381 10.259391417079016 0.03817043591926603 0.08319002670167616 4.359239357330239e-06 5.360589284064724 -0.22270615919123038 RPDPDS(ph)DEDEDYER ddPTM_A459_Selumetinib_30min_R1 2 RPDPDSDEDEDYER 14 1 H0Y6J6;Q5W012;Q96I25;Q5W011;Q5W010 H0Y6J6 RBM17 Splicing factor 45 1 RPDPDS(0.998)DEDEDY(0.002)ER;RPDPDS(1)DEDEDYER 236.75 4.3984e-19 32574000.0 5041.0 6357.9 5279.1 5104.799999999999 5791.8 5273.299999999999 6625.7 5048.9 3045.8999999999996 5247.3 True False 5158.4454919215 5613.514112292479 4562.2272160206085 4213.342508963896 5267.932712625345 5220.255389773313 6125.918114618328 4914.986770861477 5168.669836265854 5920.842068030318 0.8712351102513964 0.9480938771535115 0.7705368870847659 0.7116120410834645 0.8897269429072652 0.8816744864653908 1.034636297376571 0.8301161750961114 0.8729619498169306 1.0 12.531586656627619 -6.5066281483620845 23.10180364443248 0.9163511968110007 0.826525215545589 0.24839949487016177 0.08039136273050088 444.2776499893324 631585.0848264205 0.026770333360030443 0.029478784013297645 3.1143817919323357e-07 6.5066281483620845 -0.08982598126541175 RPDPDS(ph)DEDEDYER ddPTM_A459_Selumetinib_30min_R2 1 RPDPDSDEDEDYER 14 1 H0Y6J6;Q5W012;Q96I25;Q5W011;Q5W010 H0Y6J6 RBM17 Splicing factor 45 1 RPDPDS(0.615)DEDEDY(0.385)ER 149.6 0.00078471 92194000.0 64697.0 60972.0 73032.0 72815.0 79286.0 73737.0 76851.0 77622.0 71106.0 65211.0 True False 61101.39974261121 65648.35634411975 68333.20063122943 62897.47138711883 69325.38385416684 83893.60243215882 80424.72377736759 77847.86716898612 85329.18686763932 63328.1889914742 0.964837313614593 1.0366371972670483 1.0790329191385695 0.9931986432706396 1.0947002426281294 1.3247434320828804 1.2699672145716194 1.229276699819518 1.347412396067841 1.0 15.950560202515168 -6.5959526878747505 5.01537904685259 1.2498755930103937 1.0259405982755405 0.5448054832216642 0.0929824653078166 0.14352521661477502 6.690033404088076 0.02922329403178585 0.029334572105320724 2.5354048229474897e-07 6.5959526878747505 -0.22393499473485323 RPDPDS(ph)DEDEDYERER ddPTM_A459_Selumetinib_30min_R1 3 RPDPDSDEDEDYERER 16 2 H0Y6J6;Q5W012;Q96I25;Q5W011;Q5W010 H0Y6J6 RBM17 Splicing factor 45 1 RPDPDS(1)DEDEDYERER;RPDPDS(1)DEDEDYERER;RPDPDS(1)DEDEDYERER 120.79 0.0017819000000000003 146390800.0 6170.72 6222.49 9832.9 9187.4 7800.41 6587.92 6247.62 5408.07 4373.91 4840.659999999999 True False 6314.485769869042 5493.957978042881 8497.646188253502 7582.993058857328 7094.864292774238 6521.651506152767 5776.356993412279 5264.6304157129 7422.2058122530625 5462.005863021294 1.1560745133247075 1.0058498866209404 1.5557739045620598 1.3883165359077105 1.2989484945096217 1.1940030219127835 1.057552323866804 0.9638639261366122 1.3588791367842818 1.0 12.415215147382497 -7.002323289087962 3.5713071130471636 1.0934700254497938 1.2860098224979768 0.21646164703131665 0.16624836413444408 0.3890364885679515 10.665710774679644 0.06772054244375464 0.05527739033465694 9.946647126518256e-08 7.002323289087962 0.19253979704818303 RPDPDS(ph)DEDEDYERER ddPTM_A459_Selumetinib_30min_R2 1 RPDPDSDEDEDYERER 16 2 H0Y6J6;Q5W012;Q96I25;Q5W011;Q5W010 H0Y6J6 RBM17 Splicing factor 45 1 RPDPDS(1)DEDEDYERER 125.59 0.0013474 67325000.0 62300.0 74017.0 75622.0 82541.0 78173.0 48726.0 36028.0 29792.0 31463.0 75101.0 True False 58837.61540665989 79693.86589783375 70756.56285100806 71298.77340883308 68352.20886451303 55437.564209411445 37703.373388127635 29878.68978766891 37756.47914967132 72932.63899416827 0.8067391529787449 1.0927050905727695 0.9701632057584778 0.9775976077669993 0.9371964295708332 0.7601200912782583 0.5169615950842312 0.4096751495590064 0.5176897431709601 1.0 16.15427697705035 -6.954747239108919 2.6328959629533895 0.563556244785702 0.9691822715654541 0.49457372836139135 0.16192781715014629 0.1987462066718065 2.793086894299787 0.06227814539589293 0.05136461097431714 1.1098205467332608e-07 6.954747239108919 0.4056260267797521 RPEAS(ph)PVQK ddPTM_A459_Selumetinib_30min_R1 1 RPEASPVQK 9 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 RPEAS(1)PVQK 101.3 0.030798 5708800.0 2851.1 4056.8 2586.0 3070.5 2763.4 2869.5 3360.4 2798.5 1478.6 2741.3 True False 2917.5250827251316 3581.8279700448475 2234.8354038812104 2534.2948154234523 2513.4509579178944 2840.635435297539 3106.9223225264377 2724.2746891908837 2509.076207328767 3093.172557523204 0.9432144597394467 1.1579787106713906 0.7225058939714343 0.8193189252437757 0.8125802589980592 0.918356600697415 1.0044451981735683 0.8807380249656334 0.8111659342205788 1.0 11.59487160335887 -5.25374238652559 24.997024143167256 0.8693846962719576 1.0505965756410525 0.3599368426277765 0.09570101564804773 634.8687948840103 2061809.7962840865 0.024771921766302617 0.06295298533008079 5.575163567175617e-06 5.25374238652559 0.18121187936909489 RPEGPGAQAPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 RPEGPGAQAPSSPR 14 1 P40222 P40222 TXLNA Alpha-taxilin 1 RPEGPGAQAPS(0.5)S(0.5)PR 73.252 0.025418 7704900.0 6005.3 6189.2 8160.4 8208.8 8827.8 7356.5 8788.9 12353.0 7638.1 12556.0 True False 5671.549467120626 6663.891738585347 7635.368748371728 7090.747279030157 7718.772842466682 8369.791099341937 9197.601264874958 12388.945184850756 9165.93342634538 12193.475655594155 0.46512984708495464 0.5465128997512756 0.6261847699567722 0.5815197798649843 0.6330248290548268 0.6864155336630391 0.7543051320773547 1.0160306654786262 0.7517080187173876 1.0 13.573821793151248 -7.191737601376462 0.5091642973233023 0.9858675783397887 0.500343348885226 0.7969104444963749 0.07779593625831667 0.40059846376725433 0.22304555636529688 0.07262281637741123 0.06745935443854699 6.430761434553385e-08 7.191737601376462 -0.48552422945456264 RPEGPGAQAPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 RPEGPGAQAPSSPR 14 1 P40222 P40222 TXLNA Alpha-taxilin 1 RPEGPGAQAPS(0.086)S(0.914)PR;RPEGPGAQAPS(0.24)S(0.76)PR;RPEGPGAQAPS(0.041)S(0.959)PR;RPEGPGAQAPS(0.016)S(0.984)PR;RPEGPGAQAPS(0.041)S(0.959)PR;RPEGPGAQAPS(0.247)S(0.753)PR;RPEGPGAQAPS(0.002)S(0.998)PR 156.06 0.00016618 669477900.0 19806.08 23603.100000000002 22796.899999999998 24601.7 23078.3 20922.87 24240.5 20692.0 12297.859999999999 17679.909999999996 True False 20267.52312807709 20839.638079216496 19701.206194408165 20305.474926104267 20990.871839804804 20712.404924245988 22412.01956886149 20143.18094291147 20868.57021984322 19949.298665406943 1.0159516616602648 1.0446301110000145 0.9875638499799002 1.0178540743046247 1.0522110171323467 1.038252285037083 1.12344899661686 1.0097187515589572 1.046080394597046 1.0 14.284050407715128 -6.255208842268382 19.76759803907045 1.0490277224090463 1.0164423133429263 0.14073852116338026 0.03354567123815646 51.548523801811996 163540.35485495045 0.009925002716696671 0.012408105025438015 5.556369999107671e-07 6.255208842268382 -0.03258540906611995 RPEGPGAQAPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 RPEGPGAQAPSSPR 14 1 P40222 P40222 TXLNA Alpha-taxilin 1 RPEGPGAQAPS(0.091)S(0.909)PR;RPEGPGAQAPS(0.059)S(0.941)PR;RPEGPGAQAPS(0.244)S(0.756)PR;RPEGPGAQAPS(0.019)S(0.981)PR;RPEGPGAQAPS(0.006)S(0.994)PR;RPEGPGAQAPS(0.058)S(0.942)PR 156.29 0.00057817 1005548200.0 157024.8 172126.0 190244.0 206308.0 218617.0 159095.6 154562.2 170731.0 165155.6 212607.0 True False 148297.99023607853 185327.5107276772 178003.90816200592 178208.49449884944 191152.37799922275 181009.57477393697 161749.64855918902 171227.79894396148 198191.3348330251 206468.48349067438 0.7182596962445204 0.8976067804365306 0.8621359790732703 0.8631268631703717 0.9258186758942151 0.8766934871302655 0.7834108422968816 0.8293168819235085 0.9599108371519417 1.0 17.655562051811152 -14.52287873842211 0.16404045193487857 1.5458327155812976 0.821895392823659 0.3788580531563588 0.06163883700308304 159.56838412069965 1.4782051328020318 28.2161282725797 0.25119985389170646 3.0000000473749606e-15 14.52287873842211 -0.7239373227576387 RPEGPGAQAPSSPR ddPTM_A459_Selumetinib_30min_R1 1 RPEGPGAQAPSSPR 14 1 P40222 P40222 TXLNA Alpha-taxilin 0 100.11 0.012472 2478500.0 205.21 295.06 395.86 526.81 360.57 297.6 306.45 341.69 263.11 123.01 False True 209.99099373084917 260.51423803032753 342.1043863033318 434.8125229484541 327.9565071638038 294.6064141991804 283.33422977568944 332.62727123445876 446.47845320591944 138.79953171886677 1.5129085172720758 1.8769100644949532 2.4647373234388956 3.1326656334053813 2.3628070145659232 2.1225317589391772 2.0413197816082858 2.3964581660706377 3.2167144058543706 1.0 7.116858890342136 -10.771179677425769 7.793488934383084 0.9999981350052528 2.3464290511609516 0.40003106571953795 0.4950513894791178 1.6930736131204806e-05 1.6331326935986113e-06 0.5057117345532796 0.1226529417931726 1.6936369596582458e-11 10.771179677425769 1.3464309161556987 RPEGPGAQAPSSPR ddPTM_A459_Selumetinib_30min_R2 1 RPEGPGAQAPSSPR 14 1 P40222 P40222 TXLNA Alpha-taxilin 0 91.812 0.035479000000000004 0.0 8295.2 5981.8 8935.3 7121.8 9877.2 6678.8 6382.2 8745.5 7825.5 9530.0 False True 7834.185992316621 6440.584825481457 8360.412526019056 6151.798554209748 8636.33783271165 7598.744075890023 6678.984946089381 8770.947957104532 9390.818662738866 9254.844138086357 0.8464957243392877 0.695914996447816 0.9033553025073154 0.6647112001479657 0.9331694520030461 0.8210558667994198 0.7216744924534633 0.9477142808931323 1.0146922544154942 1.0 13.175992978366438 -7.9133250582866035 5.422825627210588 0.9994747390707394 0.7996179116500743 0.5366875102483393 0.08170576505121553 0.14923597219085363 7.065168742529996 0.04399214651672989 0.020480422402759848 1.2208855165891585e-08 7.9133250582866035 -0.19985682742066502 RPELEDSTLR ddPTM_A459_Selumetinib_30min_R1 2 RPELEDSTLR 10 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 161.19 0.0005812 25630000.0 3817.2 4290.5 4827.299999999999 5121.0 4839.1 3986.6000000000004 4409.0 3899.8999999999996 2397.0 3420.6 False True 3906.1333330217685 3788.1662654006655 4171.779174460852 4226.713483075556 4401.404259412496 3946.4984235431875 4076.425580293737 3796.4619833394754 4067.5339300467044 3859.6673294655375 1.0120388623137284 0.9814748116971073 1.0808649602033276 1.0950978730233842 1.140358451572036 1.0224970409793515 1.0561598273440356 0.983624146660636 1.0538560924653448 1.0 11.914260789457725 -9.945556719249591 10.398530579524772 0.9999995172065165 1.0481762738310803 0.08217981929044638 0.04737629758780623 0.0 0.0 0.049749844774168314 0.012066109697763458 1.133556784902964e-10 9.945556719249591 0.04817675662456378 RPEPSTLENITDDKYATVSS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 RPEPSTLENITDDKYATVSSPSK 23 2 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 RPEPSTLENITDDKY(0.014)AT(0.009)VS(0.136)S(0.662)PS(0.179)K 75.529 0.0010236000000000002 97859000.0 1391.0 1618.0 916.38 1159.9 1094.5 1143.7 1209.9 1346.8 684.49 1519.7 True False 1423.4075935851629 1428.563807812207 791.9406293150283 957.3452390195938 995.5026682496697 1132.1954163965136 1118.636268903922 1311.078488977053 1161.5295368283982 1714.768298131549 0.8300874206364443 0.8330943657920449 0.46183535710214907 0.5582942255596509 0.5805464617781844 0.6602614578483751 0.6523541811000435 0.7645805502735468 0.6773682124249834 1.0 10.743797935276255 -9.280516809195143 0.7304287752635258 1.0069751452577371 0.6492233835893048 0.4455972508615794 0.11149037339541888 2.9639125854666135 2.0732853537617144 0.1760563799506713 0.04350490395305729 5.241833123092693e-10 9.280516809195143 -0.35775176166843237 RPEPSTLENITDDKYATVSS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 RPEPSTLENITDDKYATVSSPSK 23 2 Q01804-5;Q01804-3;Q01804 Q01804-5 OTUD4 OTU domain-containing protein 4 1 RPEPSTLENIT(0.001)DDKY(0.005)AT(0.005)VS(0.199)S(0.641)PS(0.148)K 54.56 0.023475 22467000.0 6130.5 6716.0 5670.6 8310.8 5069.4 6114.6 6771.3 8044.5 5315.3 6614.6 True False 5789.791352335933 7231.095604656368 5305.7597696824605 7178.85470307034 4432.536650988986 6956.830647187687 7086.178867076404 8067.908163161335 6378.508521890733 6423.61931120525 0.9013285302004622 1.1257042571066704 0.8259766827133086 1.1175716298361067 0.6900372572292611 1.0830079290427925 1.1031442748662574 1.2559754512674524 0.9929773563579919 1.0 12.649170680302124 -6.969158544080033 24.99888614227319 1.1070302217274754 0.9412076117163896 0.23454577350566108 0.1377539983517098 270.6640647705939 219388.9987050726 0.045989727317023305 0.04055877853357323 1.0735974119961315e-07 6.969158544080033 -0.1658226100110859 RPES(ph)PPSILTPPVVPTADK ddPTM_A459_Selumetinib_30min_R2 3 RPESPPSILTPPVVPTADK 19 1 Q6P2C6;P55198 Q6P2C6 MLLT6 Protein AF-17 1 RPES(0.75)PPS(0.186)ILT(0.064)PPVVPTADK;RPES(0.935)PPS(0.065)ILTPPVVPTADK;RPES(0.986)PPS(0.014)ILTPPVVPTADK 121.65 0.00021909 13819600.0 105545.0 78298.0 95667.0 102634.0 101317.0 90949.0 96624.0 101792.0 98364.0 90680.0 True False 99679.23143011103 84303.20483224896 89511.88937435417 88655.07214647449 88588.65267452777 103476.39919717949 101117.20745682382 102088.19786742714 118039.54851979364 88061.83278506511 1.1319231984803317 0.9573183088070636 1.01646634578715 1.0067366229233192 1.005982386157559 1.17504253459881 1.1482523615380946 1.1592785959451533 1.3404166684549474 1.0 16.42622925019728 -6.763950882896878 24.96789521253082 1.17353136524906 1.0186556470630788 0.3934805881405804 0.08701009802744969 60.94954983586264 605918.8184386232 0.028598924930565022 0.02638864799226363 1.7220633229796458e-07 6.763950882896878 -0.15487571818598123 RPES(ph)PSEISPIK ddPTM_A459_Selumetinib_30min_R1 4 RPESPSEISPIK 12 1 Q7Z5K2;Q7Z5K2-2;Q7Z5K2-3 Q7Z5K2 WAPAL Wings apart-like protein homolog 1 RPES(0.91)PS(0.089)EIS(0.001)PIK;RPES(0.923)PS(0.077)EISPIK;RPES(0.937)PS(0.063)EISPIK;RPES(0.783)PS(0.21)EIS(0.007)PIK 169.3 0.00063458 62036400.0 14252.6 13605.099999999999 15837.5 16586.5 14294.900000000001 13579.399999999998 13050.4 13571.8 6696.3 11142.2 True False 14584.657849268082 12012.2085671606 13686.85448916035 13689.979142166134 13001.92881896958 13442.803565108694 12065.99782106268 13211.831776580613 11363.132021598558 12572.409904218815 1.1600526836445282 0.9554420082286504 1.0886420816241102 1.0888906141671617 1.0341636104790566 1.069230455220666 0.9597203649090217 1.0508591333907458 0.9038149494143942 1.0 13.61797359443344 -7.291048291982667 1.3916532687537189 0.974680733812992 1.0647898100349371 0.3196809990543872 0.06011605440115592 0.5574106504601238 2.0986042858854295 0.03526385695293489 0.02013010239189185 5.116249415258202e-08 7.291048291982667 0.09010907622194508 RPES(ph)PSEISPIK ddPTM_A459_Selumetinib_30min_R2 3 RPESPSEISPIK 12 1 Q7Z5K2;Q7Z5K2-2;Q7Z5K2-3 Q7Z5K2 WAPAL Wings apart-like protein homolog 1 RPES(0.766)PS(0.234)EISPIK;RPES(0.88)PS(0.111)EIS(0.009)PIK;RPES(0.929)PS(0.057)EIS(0.014)PIK 140.77 0.00053761 49189700.0 120144.0 96960.0 122526.0 126170.0 122505.0 85789.0 92790.0 103077.0 84254.0 101476.0 True False 113466.87745453851 104396.52022446123 114642.81055622183 108985.42834461013 107114.82669140454 97605.65603499557 97104.91885989674 103376.93700468398 101107.15425345358 98546.12421368826 1.1514088287074178 1.0593670837636082 1.1633416480959653 1.1059331781358057 1.0869511870313218 0.9904565685743929 0.9853753218070109 1.0490208298859176 1.0259881356085803 1.0 16.588511511217526 -6.611220746499522 3.9239096406552907 1.0119023357952273 1.116927712448843 0.7360543219754759 0.03130220542725135 0.12189117116822154 3.5964847835927456 0.010687796867725871 0.010733338257741025 2.447818729681274e-07 6.611220746499522 0.10502537665361578 RPFDPNDR ddPTM_A459_Selumetinib_30min_R1 1 RPFDPNDR 8 1 Q16629;C9JAB2;Q16629-4;A0A0B4J1Z1;Q16629-3;Q16629-2;F8WEA1 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 0 97.565 0.027285000000000004 11470000.0 1696.6 1637.8 1452.2 1353.4 1832.5 1474.2 1690.2 1298.8 967.39 1169.3 False True 1736.1274789910763 1446.0456146074362 1254.9992163636093 1117.0540964644515 1666.7506985541527 1459.3708864665045 1562.7068532121732 1264.351604903026 1641.5901746299041 1319.391044946516 1.315855133048484 1.0959947167642434 0.9511957968567862 0.8466436851629028 1.2632727082225401 1.1060942789146055 1.1844152339805523 0.9582842097842789 1.244202907786485 1.0 10.365656502771909 -6.302530358013546 24.999876298911456 1.1258800214685725 1.0483035373951426 0.05949021776018437 0.14303287018838354 1634.9317158375272 994693.4503177775 0.04540532658087797 0.05148511502131681 4.982756243355745e-07 6.302530358013546 -0.07757648407342987 RPGAPSLS(ph)PAPR ddPTM_A459_Selumetinib_30min_R1 3 RPGAPSLSPAPR 12 1 Q5QP82;Q5QP82-2 Q5QP82;Q5QP82-2 DCAF10 DDB1- and CUL4-associated factor 10 1 RPGAPS(0.001)LS(0.999)PAPR;RPGAPS(0.009)LS(0.991)PAPR;RPGAPS(0.004)LS(0.996)PAPR 91.355 0.011886 26923200.0 5177.6 6334.9 6756.5 6999.6 6329.7 5724.6 5890.1 5282.6 3580.7 5175.6 True False 5298.228006144171 5593.206962984888 5839.004410797908 5777.251258765018 5757.179752599299 5667.015721520924 5445.805014853283 5142.488287696899 6076.1863760192855 5839.938674613173 0.9072403498304057 0.9577509755880051 0.9998400216393836 0.9892657407310348 0.985828802899312 0.9703895943558511 0.9325106509297383 0.8805723097832919 1.040453798330641 1.0 12.511737504059163 -5.887146961941166 0.0032874587195026958 1.921636757124859 1.103362967556584e-08 0.06038452574344155 0.04414153922500576 206702.46611462205 161.12992237303897 46363.55270913823 47825.751692390695 1.2967403896709228e-06 5.887146961941166 -1.9216367460912294 RPGAPSLS(ph)PAPR ddPTM_A459_Selumetinib_30min_R2 3 RPGAPSLSPAPR 12 1 Q5QP82;Q5QP82-2 Q5QP82;Q5QP82-2 DCAF10 DDB1- and CUL4-associated factor 10 1 RPGAPS(0.002)LS(0.998)PAPR;RPGAPS(0.066)LS(0.934)PAPR;RPGAPS(0.002)LS(0.998)PAPR 99.055 0.0075555000000000015 26706400.0 43553.0 38449.0 47525.0 50199.0 57861.0 34839.0 33788.6 41630.0 36908.0 45052.0 True False 41132.498616472876 41397.91466697929 44467.293241307605 43361.8096018949 50591.983896096965 39637.756013046135 35359.836850840715 41751.13640778252 44290.63129568285 43751.23170084641 0.9401449288952733 0.9462114106876311 1.0163666601515893 0.991099174038934 1.1563556482712283 0.9059803455151482 0.8082020888604297 0.9542848231853277 1.0123287865019353 1.0 15.417036012350183 RPGFS(ph)PTSHR ddPTM_A459_Selumetinib_30min_R2 3 RPGFSPTSHR 10 1 Q8WUA4;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 RPGFS(0.991)PT(0.009)SHR;RPGFS(0.978)PT(0.009)S(0.013)HR;RPGFS(0.914)PT(0.043)S(0.043)HR 79.88600000000002 0.025126 119450000.0 26476.4 26879.6 26549.5 24502.0 28878.6 21756.5 25849.5 23645.300000000003 22647.9 27659.9 True False 25004.94768142681 28941.17888846358 24841.334074909966 21164.785331692427 25250.612090040362 24753.260389156927 27051.552969812517 23714.103908309855 27178.112835198222 26861.286817949094 0.9308916527676607 1.0774308425583197 0.9248005966084482 0.7879289430597873 0.9400373206680308 0.9215217631575434 1.0070832850694362 0.882835735645537 1.0117948934984538 1.0 14.71324079978035 -7.205813805325114 24.985881955433033 0.9656650723149997 0.9308195837430651 0.0765456890960684 0.07348691425883476 1131.5740900077062 508279.90707895707 0.029900615054659786 0.0231609063599952 6.225671405998926e-08 7.205813805325114 -0.03484548857193459 RPGGS(ph)SPLNAVPCEGPPGSEPPR ddPTM_A459_Selumetinib_30min_R2 1 RPGGSSPLNAVPCEGPPGSEPPR 23 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 RPGGS(0.5)S(0.5)PLNAVPCEGPPGSEPPR 87.28 0.0001213 26674000.0 53157.0 50102.0 62352.0 61666.0 70401.0 57454.0 52370.0 52866.0 52437.0 63749.0 True False 50202.74674433098 53944.66229667862 58340.340203724554 53266.98442021655 61556.59698707451 65367.76698451595 54805.3087691863 53019.83130756255 62925.865212195764 61908.40073020639 0.8109197807113764 0.8713625559763153 0.9423654870034317 0.860416095262278 0.9943173504890713 1.0558787856495486 0.885264489516132 0.8564238565719091 1.0164349986429697 1.0 15.917847570402136 -4.497517615562309 0.7858131085681819 0.9548416592522011 0.6622901518632212 0.36332595020278324 0.06301880350761684 4.793397682157405 1.6702585077655638 0.025235407833095032 1.361681005238872 3.180404684265574e-05 4.497517615562309 -0.29255150738897995 RPGGSS(ph)PLNAVPCEGPPGSEPPR ddPTM_A459_Selumetinib_30min_R2 1 RPGGSSPLNAVPCEGPPGSEPPR 23 1 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 RPGGS(0.386)S(0.614)PLNAVPCEGPPGSEPPR 103.92 1.3385e-05 21332000.0 41442.0 35422.0 31523.0 46406.0 49901.0 27981.0 34469.0 39402.0 33404.0 39714.0 True False 39138.819545470324 38138.75350031833 29494.844499647323 40085.42274518486 43631.99025939982 31835.12876377176 36071.876799027734 39516.653296647746 40085.733385742635 38567.35363063603 1.0148173483798573 0.9888869707156354 0.7647619482042463 1.039361505824007 1.1313192675149142 0.8254423953652729 0.9352956167149096 1.0246140732159967 1.0393695603190278 1.0 15.235092535758774 -7.772221691246407 24.097075589366053 1.0239939183582363 0.9557472036785377 0.08155425752561152 0.09853421317150902 389.8987439240339 871351.637777575 0.055222314176653416 0.026979753337527793 1.6895782443665877e-08 7.772221691246407 -0.06824671467969856 RPGHPAQPLPLPQTASS(ph)PQPQQK ddPTM_A459_Selumetinib_30min_R2 1 RPGHPAQPLPLPQTASSPQPQQK 23 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 RPGHPAQPLPLPQT(0.004)AS(0.164)S(0.832)PQPQQK 78.794 0.00046688 10528000.0 19282.0 22929.0 23192.0 30911.0 32084.0 26949.0 21471.0 32910.0 26941.0 31503.0 True False 18210.383631961748 24687.580571644718 21699.851969540367 26700.868475550757 28053.321085400785 30660.980131335014 22469.444043979376 33005.7626514562 32329.95279443457 30593.426535376133 0.5952384447980847 0.8069570285988625 0.7092978599323666 0.8727648877341578 0.9169721820130823 1.002208108198693 0.7344533316004096 1.0788514523958475 1.0567614175891817 1.0 14.900934080716421 -3.7786690856965417 0.29230506306011705 1.0348766775059182 8.668988477176189e-18 0.6291388448603075 0.09399242459353244 9.917186703575686 0.4386225587489457 0.10643738891316686 4.07381521940617 0.00016646805845107958 3.7786690856965417 -1.0348766775059182 RPGNSTVTSS(ph)PPVTPK ddPTM_A459_Selumetinib_30min_R2 2 RPGNSTVTSSPPVTPK 16 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 RPGNSTVT(0.001)S(0.181)S(0.811)PPVT(0.007)PK;RPGNS(0.001)T(0.001)VT(0.011)S(0.281)S(0.702)PPVT(0.004)PK 64.476 0.029905 8102700.0 74524.0 67820.0 82494.0 86548.0 86365.0 60689.0 61196.0 77088.0 71517.0 80006.0 True False 70382.25442320907 73021.57592432923 77186.42585267617 74760.01309637229 75515.05658710375 69048.35887010982 64041.73525757354 77312.31331739457 85822.39835193883 77696.01889944759 0.9058669339840459 0.9398367761780958 0.9934411948772958 0.9622116313723228 0.9719295487305935 0.888698801407967 0.8242601894500526 0.9950614511851681 1.1045919670994753 1.0 16.24555305718927 -7.997466315612047 24.999735222923213 1.051472912501048 0.9297919521893506 0.501275381774176 0.050840769458438004 63.03955008696909 622009.4744678328 0.029816218772123943 0.014190097333456156 1.0058510749621344e-08 7.997466315612047 -0.1216809603116974 RPGPAAS(ph)PTPGPGPAPPAAPAPPR ddPTM_A459_Selumetinib_30min_R2 1 RPGPAASPTPGPGPAPPAAPAPPR 24 1 Q9NUE0 Q9NUE0 ZDHHC18 Palmitoyltransferase ZDHHC18 1 RPGPAAS(0.966)PT(0.034)PGPGPAPPAAPAPPR 71.295 0.0074215 0.0 6404.9 6624.4 5459.5 5458.1 3378.2 4082.4 6785.4 6787.0 3303.0 4260.1 True False 6048.941298846166 7132.470179196793 5108.241713854158 4714.697364252327 2953.8003145088173 4644.713543662547 7100.934545015026 6806.749046351668 3963.6922935309553 4137.099843930921 1.4621211783708568 1.7240266003393767 1.234739770989064 1.139614111844251 0.7139784936160071 1.1226979572359823 1.716403957577194 1.6452948449714337 0.9580847557608857 1.0 12.014404060365623 -5.282459932204476 17.677054304374018 1.211799297883774 1.5930712518253187 0.2311825255505262 0.29113108527783654 28.647230454813982 24092.17775451486 0.0840165059567676 0.17603867042571408 5.218432470197333e-06 5.282459932204476 0.3812719539415448 RPGPGTLY(ph)DVPR ddPTM_A459_Selumetinib_30min_R2 1 RPGPGTLYDVPR 12 1 P56945-6;A0A2R8Y6M6;A0A2R8Y5C9;A0A2R8Y8C4;A0A2R8YFS8;A0A2R8Y5E4;A0A2R8Y4C2;A0A2R8YFK2;A0A2R8Y596;P56945;P56945-8;P56945-2;P56945-3;P56945-5;P56945-7;P56945-4;H3BN62 P56945-6 BCAR1 Breast cancer anti-estrogen resistance protein 1 1 RPGPGT(0.005)LY(0.995)DVPR 149.23 0.00098972 3776500.0 16209.0 13989.0 15505.0 15742.0 21273.0 17957.0 15981.0 16140.0 17716.0 15744.0 True False 15308.168669768074 15061.911318275446 14507.425180567581 13597.912443535326 18600.495556967056 20430.413752583878 16724.148165750743 16186.964727879164 21259.695026398545 15289.4298121754 1.00122560866055 0.9851192296446023 0.9488532508265882 0.8893668770242125 1.2165591382717857 1.3362443206557362 1.0938372700094308 1.0587029684383018 1.3904831826670774 1.0 13.900246984908373 -6.267626913028234 24.902309512658015 1.1888132675209864 0.9576905253846025 0.4817945627660506 0.11496519107684061 408.4905171994424 1644005.2073363776 0.03500230797923621 0.040683982534893734 5.399742960723062e-07 6.267626913028234 -0.23112274213638384 RPGQSFHVNSEVNSVLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 RPGQSFHVNSEVNSVLSPR 19 1 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2 Q5T1Z4 PUM1 Pumilio homolog 1 1 RPGQSFHVNSEVNS(0.245)VLS(0.755)PR;RPGQSFHVNSEVNS(0.006)VLS(0.994)PR 134.34 0.00010701 27268300.0 3031.7 3340.0 3412.8 3667.4 5873.9 2642.1 3833.5 3036.6 1258.65 1859.49 True False 3102.3327113387045 2948.9512472761276 2949.3605051685186 3026.9574356241565 5342.606782121271 2615.5228728348598 3544.336008631445 2956.059503733084 2135.837121841171 2098.173654466429 1.4785872011759844 1.405484832486877 1.4056798868340326 1.4426629698550473 2.5463129663973927 1.24657121076091 1.6892481711828466 1.4088726628706134 1.0179505958882702 1.0 11.034918371571422 -8.147280254341428 2.7135867294487777 0.988455353847541 1.6036148195045865 0.32327630573379507 0.3386009986811911 0.3492611736258128 4.608507207982629 0.29621864861505204 0.09224503403513255 7.123931677090466e-09 8.147280254341428 0.6151594656570455 RPGQSFHVNSEVNSVLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 RPGQSFHVNSEVNSVLSPR 19 1 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2 Q5T1Z4 PUM1 Pumilio homolog 1 1 RPGQSFHVNSEVNS(0.041)VLS(0.959)PR;RPGQSFHVNSEVNS(0.383)VLS(0.617)PR 134.58 0.00013989 21069000.0 22629.2 19665.3 37687.0 46570.0 60336.0 39178.0 30951.6 33864.0 39964.0 49994.0 True False 21371.559655864992 21173.565276094243 35262.259450503065 40227.08566226908 52756.05226931622 44574.41387752582 32390.910729431853 33962.53863351301 47957.91668745716 48550.54331998839 0.4401919771527307 0.4361138687273357 0.7262999966467006 0.8285609781365202 1.0866212540941105 0.9181032966766906 0.6671585633130582 0.6995295276032584 0.9877936148185752 1.0 15.567199820212803 -5.4072220257381645 2.363136521226021 0.8722099207756759 0.42280411803287554 0.6715161682706425 0.12330209159908251 0.1992126607094062 2.127586593459044 0.03781667020936914 0.10369373943694161 3.915416568559962e-06 5.4072220257381645 -0.4494058027428004 RPGS(ph)VSSTDQER ddPTM_A459_Selumetinib_30min_R2 1 RPGSVSSTDQER 12 1 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 RPGS(0.975)VS(0.005)S(0.001)T(0.02)DQER 128.85 0.0042977 10264000.0 12339.0 9891.5 11902.0 12542.0 13198.0 11334.0 9621.6 10414.0 8848.1 12050.0 True False 11653.247776930608 10650.14624381454 11136.238277917786 10833.75796384322 11539.949248382976 12895.155620191872 10069.023464838712 10444.30301586949 10617.96723657016 11702.08519034004 0.9958266058898848 0.910106709238977 0.9516456338149585 0.9257972222579942 0.9861446964946978 1.1019536612873662 0.8604469460836429 0.8925164059214987 0.9073568568219954 1.0 13.51447800557382 RPGT(ph)SPALLQGTAEEDHVDLSLSCTLVPR ddPTM_A459_Selumetinib_30min_R1 1 RPGTSPALLQGTAEEDHVDLSLSCTLVPR 29 1 P38936 P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 1 RPGT(0.499)S(0.499)PALLQGT(0.003)AEEDHVDLSLSCTLVPR 74.748 3.6046e-05 5262300.0 738.27 615.85 681.0 620.77 770.05 498.28 547.99 721.58 323.08 501.08 True False 755.4702545766486 543.7459956991022 588.5239404652376 512.3641727960973 700.3991134633694 493.26775560204135 506.6546731107202 702.4413543778302 548.2431631704172 565.3984989325239 1.336173081469055 0.961703995899703 1.0409011371207646 0.906200093851406 1.238770733890747 0.8724249472422267 0.8961019070041529 1.242382771981256 0.9696579743411132 1.0 9.143124242760795 -4.755201307053038 24.985400942320965 1.018162877957626 1.3361736114057716 0.3768637155358775 0.12409824904085132 224.07979057544068 897422.3286021978 0.029991086502781397 0.27223114810889715 1.757108958390539e-05 4.755201307053038 0.3180107334481457 RPGTQGHLGPEKEEEESDGEPEDS(ph)STS ddPTM_A459_Selumetinib_30min_R2 1 RPGTQGHLGPEKEEEESDGEPEDSSTS 27 2 Q8IYB7;H7C1Q8 Q8IYB7 DIS3L2 DIS3-like exonuclease 2 1 RPGTQGHLGPEKEEEES(0.175)DGEPEDS(0.445)S(0.171)T(0.059)S(0.149) 54.363 0.011839 17797000.0 16611.0 16343.0 17460.0 13733.0 16418.0 14632.0 15160.0 12652.0 12156.0 17834.0 True False 15687.827119101565 17596.45554897246 16336.642609010638 11862.541709253617 14355.424061217745 16647.425183928663 15864.970038970108 12688.815225348651 14587.539667018562 17319.086081703266 0.9058114871127615 1.0160152484929457 0.9432739425130215 0.6849403977376028 0.828878844616606 0.9612184560659827 0.9160396780827045 0.7326492382732447 0.8422811456794799 1.0 14.080075181428045 -5.548665974516495 24.99366099215916 0.8448085903333188 0.965596341514272 0.20099448053904645 0.09339352085004833 300.04003286062357 290805.2339219277 0.02572095920967488 0.044551762737593946 2.827053488272868e-06 5.548665974516495 0.1207877511809532 RPHGSTLSVSAS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 RPHGSTLSVSASPEK 15 1 X6RAB3;Q92738;Q92738-2 X6RAB3 USP6NL USP6 N-terminal-like protein 1 RPHGSTLSVS(0.031)AS(0.969)PEK 95.554 0.015511000000000004 0.0 6929.5 7435.5 8783.4 15231.0 15830.0 15075.0 10160.0 8366.1 12121.0 11779.0 True False 6544.386130986354 8005.778941099234 8218.285606642838 13156.511525059483 13841.293878004442 17151.44441277506 10632.460131658074 8390.443965917588 14545.53868903685 11438.909664482595 0.5721162525923636 0.6998725556821985 0.7184500837663156 1.1501543338444205 1.2100186367395807 1.4993950398987486 0.929499440376864 0.7335003258194805 1.271584365614865 1.0 13.481661923220802 -5.711365789775332 4.972961790823665 1.115383485467287 0.6559481608945058 0.5251900021770065 0.19654548277850056 0.17102355314467554 9.034712914464365 0.058759869767988464 0.10166526110139841 1.9437222684172827e-06 5.711365789775332 -0.45943532457278125 RPHT(ph)PTPGIYMGR ddPTM_A459_Selumetinib_30min_R2 2 RPHTPTPGIYMGR 13 1 P62995;H7C2L4;P62995-3;H7BXF3 P62995 TRA2B Transformer-2 protein homolog beta 1 RPHT(0.976)PT(0.024)PGIYMGR;RPHT(0.656)PT(0.344)PGIYMGR 86.411 0.03308 51547000.0 27181.3 25872.3 34116.0 30596.4 33614.3 18391.6 28414.0 32949.0 26410.9 27699.6 True False 25670.672161365106 27856.622217443575 31921.01370269225 26429.117538266037 29391.371118345214 20924.875957677876 29735.307301272853 33044.87613499941 31693.817982203072 26899.840575796108 0.9543057360891208 1.0355683015648933 1.1866618172976864 0.982500898612997 1.0926225021865346 0.7778810398045862 1.1054083096696132 1.2284413374825898 1.178215829677462 1.0 14.71531000210124 -7.511842342059662 24.940678744421565 1.1553821416916423 1.0112193244737484 0.21973761034112105 0.11247786950679173 740.1825552788576 1672716.8031592565 0.04971966682451965 0.03122546850230248 3.077213704653564e-08 7.511842342059662 -0.14416281721789392 RPILQLS(ph)PPGPR ddPTM_A459_Selumetinib_30min_R1 2 RPILQLSPPGPR 12 1 Q8N3X1-2;Q8N3X1;F5GXL1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 RPILQLS(1)PPGPR;RPILQLS(1)PPGPR 108.66 0.0040907 359720000.0 4159.2 5701.9 5422.8 5973.8 5127.9 4299.6 4769.7 4284.4 2766.4 3932.6 True False 4256.101267605612 5034.318897258608 4686.4135453082035 4930.587972114189 4664.082350404276 4256.349927724449 4409.9176888924985 4170.763794307457 4694.378750138176 4437.387516767865 0.9591457251643642 1.1345231576541548 1.0561199641904897 1.11114658196577 1.0510874546745768 0.9592017626679399 0.993809459333546 0.93991425778053 1.0579149854276193 1.0 12.115494833787508 -6.631769656858999 5.568304772345419 0.9870142838172574 1.0708129881659592 0.32742460646046856 0.05163160366636022 0.2173413078689221 9.865845185807594 0.01627239964589445 0.016231745995158676 2.3346960209631966e-07 6.631769656858999 0.08379870434870174 RPILQLS(ph)PPGPR ddPTM_A459_Selumetinib_30min_R2 2 RPILQLSPPGPR 12 1 Q8N3X1-2;Q8N3X1;F5GXL1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 RPILQLS(1)PPGPR;RPILQLS(1)PPGPR 72.615 0.029109 288290000.0 37624.0 40136.0 40496.0 38824.0 49119.0 31683.7 35724.6 37888.0 32457.5 38364.0 True False 35533.008700805345 43214.30214241929 37890.531448711045 33536.104224864386 42948.23209056854 36047.84207900773 37385.864686951936 37998.24780730393 38949.90693832303 37256.33163835729 0.9537441594014131 1.1599183344698374 1.0170226048154676 0.900145096151583 1.1527767281937964 0.9675628408325269 1.0034768063010606 1.0199138276990964 1.0454573820204596 1.0 15.18519800907081 -5.481338868821325 24.98351891268001 1.012649782683062 1.0647410530300407 0.0487221568735573 0.07554997577472612 1290.774426703961 776314.4611154352 0.018784526573068946 0.039095597836028805 3.3011186271856696e-06 5.481338868821325 0.05209127034697869 RPIS(ph)DDDCPSASK ddPTM_A459_Selumetinib_30min_R1 2 RPISDDDCPSASK 13 1 Q96PU4 Q96PU4 UHRF2 E3 ubiquitin-protein ligase UHRF2 1 RPIS(0.793)DDDCPS(0.206)AS(0.001)K;RPIS(0.989)DDDCPS(0.011)ASK 174.18 0.00023381 27911000.0 3543.3999999999996 3611.6 4197.2 4289.6 4495.6 3853.7 3975.2 3620.2 2264.1 3112.8999999999996 True False 3625.9543257438304 3188.7521930127114 3627.2432935693014 3540.5018857646774 4088.9737737626438 3814.9352768796393 3675.3474635481207 3524.1805359331215 3842.0123366786574 3512.4710372137224 1.0323086759514262 0.9078372915331419 1.0326756449062773 1.007980378557994 1.1641302463254568 1.0861115256072966 1.0463708951928044 1.0033336926042493 1.093820360644552 1.0 11.778270614012618 -5.701801849360191 2.3482000650033896 1.0651670590431275 0.97257319843497 0.2695550576033363 0.05535971610056445 0.3530400965144153 3.9526210989365644 0.016286142678771747 0.03203200342281061 1.987001297217224e-06 5.701801849360191 -0.09259386060815744 RPISDDDCPS(ph)ASK ddPTM_A459_Selumetinib_30min_R1 2 RPISDDDCPSASK 13 1 Q96PU4 Q96PU4 UHRF2 E3 ubiquitin-protein ligase UHRF2 1 RPIS(0.187)DDDCPS(0.808)AS(0.005)K;RPISDDDCPS(0.969)AS(0.031)K 143.64 0.0012784 34559900.0 6022.1 6894.0 8207.8 7928.9 7329.4 6543.7 7133.1 6748.1 3823.8 5112.4 True False 6162.40321303322 6086.8472750663495 7093.225842218171 6544.266458886504 6666.457064110672 6477.876319204221 6595.044524108243 6569.118467082013 6488.7093206977825 5768.626338993044 1.0682618098139656 1.0551640750107683 1.2296213041693296 1.1344583743707786 1.1556402984621728 1.122949544403145 1.1432608278905194 1.1387665071453912 1.1248274614074647 1.0 12.494012100957454 -10.584042351316873 9.949237688149719 0.9999999909545378 1.1323150452786068 0.4280607606284945 0.04514140730839305 6.321371752993322e-11 0.0 0.044899632133753406 0.010889760262326268 2.605899416783098e-11 10.584042351316873 0.13231505432406898 RPISDDDCPS(ph)ASK ddPTM_A459_Selumetinib_30min_R2 2 RPISDDDCPSASK 13 1 Q96PU4 Q96PU4 UHRF2 E3 ubiquitin-protein ligase UHRF2 1 RPIS(0.115)DDDCPS(0.884)AS(0.001)K;RPIS(0.027)DDDCPS(0.961)AS(0.012)K 200.0 0.000219 32248500.0 74833.0 76958.0 79229.0 87237.0 77541.0 57029.0 58608.0 61645.0 55189.0 68882.0 True False 70674.08144023408 82860.43114102802 74131.49239801282 75355.1701077811 67799.60635466466 64884.22709228187 61333.388129548825 61824.37674412088 66228.34210950045 66893.19768307074 1.0565211992866084 1.2386974163442968 1.1082067379890548 1.1264997446347509 1.0135500873480192 0.969967490561491 0.9168852776352028 0.9242251661676404 0.9900609389803687 1.0 16.0295718913451 -6.377172256369437 1.8760580720370985 0.9510829899140243 1.1453556304652674 0.7341737204148164 0.048869130637546006 0.16040386792376082 1.116509667050651 0.016896206755491895 0.02038656724050928 4.1959252592176197e-07 6.377172256369437 0.19427264055124316 RPLDS(ph)PEAEELPAMK ddPTM_A459_Selumetinib_30min_R1 2 RPLDSPEAEELPAMK 15 1 Q5VWG9 Q5VWG9 TAF3 Transcription initiation factor TFIID subunit 3 1 RPLDS(1)PEAEELPAMK;RPLDS(1)PEAEELPAMK 147.84 0.00016235 72685000.0 13470.8 16125.0 17524.1 18718.7 16434.8 14479.2 15687.8 14416.7 8486.5 12280.1 True False 13784.64343038606 14237.077503690874 15144.423472990997 15449.830438517176 14948.275241799609 14333.552394061739 14504.456615679766 14034.322283958625 14400.970670563775 13856.37045330343 0.9948235345497515 1.0274752361500756 1.092957461265081 1.11499836776043 1.0788016452198608 1.0344377297335137 1.0467717115791912 1.0128426005392177 1.0393032373878621 1.0 13.758261786031527 -7.3486494946385035 1.6278062335355978 1.0197590049054455 1.0630131462023231 0.21779548853502084 0.033523642719592725 0.6736793797815557 3.468134223502944 0.02209193731344796 0.012449528580262706 4.480747852959315e-08 7.3486494946385035 0.04325414129687766 RPLDS(ph)PEAEELPAMK ddPTM_A459_Selumetinib_30min_R2 4 RPLDSPEAEELPAMK 15 1 Q5VWG9 Q5VWG9 TAF3 Transcription initiation factor TFIID subunit 3 1 RPLDS(1)PEAEELPAMK;RPLDS(1)PEAEELPAMK;RPLDS(1)PEAEELPAMK;RPLDS(1)PEAEELPAMK 117.29 0.0011078 44542500.0 230165.0 210586.0 231846.0 236606.0 245611.0 182767.0 187285.0 210360.0 175186.0 209345.0 True False 217373.35072349728 226737.26905928666 216929.2807748388 204379.8546318835 214755.15038980093 207941.49525636208 195994.12359818732 210972.11277302727 210228.0951058173 203300.66590636765 1.069221046347241 1.1152805036246807 1.0670367448513325 1.0053083383701895 1.056342582216178 1.0228274183427013 0.9640604113340906 1.0377344896164422 1.0340747983710008 1.0 17.63325541513958 -5.603919727771112 4.267563463557226 1.0185733731844866 1.0923479686488509 0.592511905981803 0.025808149107242117 0.14411876059314285 4.924938193375405 0.007264772648860971 0.013258018284570077 2.4893173853506677e-06 5.603919727771112 0.07377459546436427 RPLDSPLCTSLGFAS(ph)PLHSLEMSK ddPTM_A459_Selumetinib_30min_R1 1 RPLDSPLCTSLGFASPLHSLEMSK 24 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 RPLDS(0.004)PLCT(0.014)S(0.039)LGFAS(0.799)PLHS(0.143)LEMS(0.001)K 58.324 0.0076819 8024200.0 1615.7 1985.7 2420.6 2474.2 2159.4 2101.4 1788.9 1973.5 1215.5 1795.7 True False 1653.3426663950736 1753.2133208731148 2091.8958154040433 2042.127416486145 1964.0826512730353 2080.261823918539 1653.9618327483483 1921.1563691685585 2062.614723392477 2026.195586599211 0.8159837467468094 0.865273487154183 1.0324254130447024 1.0078629279385976 0.9693450446062678 1.026683622093005 0.8162893274900357 0.9481593888934723 1.0179741467379229 1.0 10.984557727407964 -5.086836477314795 5.042066417784088 0.9719740753719669 0.826309119921627 0.460885572643578 0.05989291449727652 0.1883341477004994 7.857802193279409 0.01610865661912483 0.04704498941637137 8.187730185296697e-06 5.086836477314795 -0.14566495545033986 RPLEAGS(ph)PGQDLEPACDGAR ddPTM_A459_Selumetinib_30min_R2 2 RPLEAGSPGQDLEPACDGAR 20 1 Q9HCM7;A0A3B3IRR3;A0A1B0GUN3 Q9HCM7 FBRSL1 Fibrosin-1-like protein 1 RPLEAGS(1)PGQDLEPACDGAR;RPLEAGS(1)PGQDLEPACDGAR 81.726 0.0018422 17304700.0 33422.0 36113.0 43902.0 46819.0 48525.0 34541.0 39040.0 38435.0 31249.0 37739.0 True False 31564.539038866573 38882.75097840313 41077.39311688346 40442.17143272011 42428.855680995934 39298.709218020806 40855.43735629241 38546.83948674321 37499.67317001172 36649.37701230229 0.8612571784854934 1.0609389339783633 1.1208210470561284 1.1034886464548816 1.1576965050934866 1.0722886013813877 1.1147648524169522 1.0517733895941528 1.0232008352399553 1.0 15.161501054336886 -4.766017165519512 4.1544799774865995 1.0871567819716397 0.839351287651095 0.6759537361713244 0.04507252643462798 0.12883884572923282 4.386100493461357 0.01132489825185463 0.0975134292381149 1.71388956456578e-05 4.766017165519512 -0.24780549432054466 RPLEDGDQPDAK ddPTM_A459_Selumetinib_30min_R2 2 RPLEDGDQPDAK 12 1 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4 FUBP1 Far upstream element-binding protein 1 0 ; 116.71 0.0066893000000000005 7483300.0 76801.0 60306.0 65928.0 78381.0 73346.0 74048.0 76552.0 107689.0 64643.0 98339.0 False True 72532.7078787623 64931.27628564726 61686.26425697905 67705.37258523311 64131.61975844054 84247.43985918202 80111.81968491021 108002.35716112629 77573.40627633105 95499.6975545934 0.759507199876714 0.679910805461228 0.6459315143036495 0.7089590262474772 0.6715374121659289 0.8821749389417815 0.8388698785052534 1.1309183162531549 0.8122895492101994 1.0 16.543208543722137 -7.021018159884478 1.6715410198373957 0.9684312434318358 0.6878134602650824 0.6557045259956393 0.08719330727396715 0.21157528456066155 1.1897132415752907 0.03953309423695337 0.029349467863042492 9.527563239905801e-08 7.021018159884478 -0.28061778316675345 RPLEEDFRRS(ph)PTEDFR ddPTM_A459_Selumetinib_30min_R2 1 RPLEEDFRRSPTEDFR 16 3 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 1 RPLEEDFRRS(0.917)PT(0.083)EDFR 64.65 0.040715 23487000.0 49982.0 62648.0 63657.0 73277.0 63587.0 36847.0 24950.0 25359.0 17475.0 54583.0 True False 47204.200533799 67452.90015493023 59561.377924501176 63296.54619012429 55598.6325850075 41922.339786237004 26110.22443748709 25432.79049159156 20970.488292295922 53007.04696633449 0.8905268871850008 1.2725270320712359 1.123650181122699 1.1941156848508236 1.0488913411893888 0.7908823861261779 0.49258024983112253 0.47980017652642065 0.39561698854143995 1.0 15.69389654955658 -6.898196138948943 2.389186685641994 0.5500329443174226 1.130258512048411 0.6463140033275527 0.17908017429292997 0.1616663486942775 1.8771715295594522 0.06852337340054002 0.05811754354412987 1.2641652878319374e-07 6.898196138948943 0.5802255677309884 RPLIVFDGS(ph)S(ph)T(ph)S(ph)TSIK ddPTM_A459_Selumetinib_30min_R1 1 RPLIVFDGSSTSTSIK 16 1 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 4 RPLIVFDGS(0.999)S(0.997)T(0.545)S(0.545)T(0.495)S(0.418)IK 64.842 0.036796 3731100.0 461.16 272.42 739.19 533.09 1692.3 1513.0 843.13 1234.7 1650.7 458.11 True False 471.9041307388455 240.5249397553779 638.8120580800278 439.9958388386544 1539.2317637998326 1497.780593694086 779.5320252921427 1201.9517451291701 2801.1173376420916 516.9128808692793 0.9129277837790698 0.46531040076016905 1.2358215121390546 0.8511992158112301 2.977739229889852 2.897549372682117 1.5080530088188622 2.3252501332678697 5.418935068771209 1.0 9.013777342793302 -6.256348300113884 24.166323922946532 2.705671671214672 0.8640647327957833 0.393712155689783 1.1072815614439608 284.05005648347225 1348325.3122025118 0.3275886726980821 0.40949588232063905 5.541810866387107e-07 6.256348300113884 -1.8416069384188887 RPLPGPS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 RPLPGPSPPR 10 1 O14924-5;O14924-4;O14924;E9PBG5 O14924-5 RGS12 Regulator of G-protein signaling 12 1 RPLPGPS(1)PPR 74.53699999999998 0.031926 3355000.0 13450.0 14059.0 14245.0 14319.0 14849.0 8201.7 8449.3 7407.4 9685.9 11816.0 True False 12702.502844615983 15137.280093189984 13328.4922087833 12368.72749834723 12983.535868255705 9331.409727380244 8842.20919197032 7428.954307638913 11623.350646658027 11474.841378345054 1.1069872276045343 1.3191711845147214 1.1615404317428208 1.0778996493745951 1.1314784614589801 0.8132059886239627 0.7705735443678593 0.647412374837581 1.012942163069307 1.0 13.486186590333922 -6.730937174445268 4.897474713328206 0.8203998701428377 1.1677843821142673 0.6342130877571625 0.11705886877410365 0.11518040648872951 6.688387810612623 0.03994548089454924 0.038505601207346106 1.8580732267270718e-07 6.730937174445268 0.3473845119714296 RPLS(ph)GPDVGTPQPAGLASGAK ddPTM_A459_Selumetinib_30min_R2 3 RPLSGPDVGTPQPAGLASGAK 21 1 O96013 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 RPLS(0.895)GPDVGT(0.105)PQPAGLASGAK;RPLS(0.999)GPDVGT(0.001)PQPAGLASGAK;RPLS(1)GPDVGTPQPAGLASGAK 199.87 5.857899999999999e-17 130063000.0 341049.0 290018.0 347702.0 365908.0 379292.0 306965.0 311279.0 308403.0 273586.0 313609.0 True False 322094.86190731876 312261.44804514985 325331.23186931433 316070.69917349285 331641.94804649806 349246.64239917044 325754.0902876367 309300.40167113475 328310.8446315347 304554.2933159624 1.0575942253198143 1.0253063407685787 1.0682208033488356 1.0378139665415342 1.0889419565740068 1.146746737984224 1.069609253380908 1.015583784104624 1.078004322503265 1.0 18.216339916740488 -6.248863691528996 24.16642957479797 1.071429897659127 1.047166653515421 0.04607636242198976 0.03919721071524544 1458.86289179905 2803458.318157934 0.012104183054557033 0.01550645146369084 5.638145879499181e-07 6.248863691528996 -0.024263244143706064 RPLS(ph)PETR ddPTM_A459_Selumetinib_30min_R2 1 RPLSPETR 8 1 Q9P227 Q9P227 ARHGAP23 Rho GTPase-activating protein 23 1 RPLS(1)PETR 74.944 0.030502 313270000.0 2765.2 3903.1 5239.6 4368.5 5795.3 3645.1 5166.6 4675.6 5134.2 4323.8 True False 2611.5212539726494 4202.455219555429 4902.489840445138 3773.502763917166 5067.24260336065 4147.1794380767105 5406.85713742368 4689.205221912754 6161.183461533945 4198.960659418448 0.6219446824572876 1.0008322440766724 1.1675484097353102 0.8986754270852808 1.2067849676073075 0.987668086095165 1.287665585838693 1.1167537879629013 1.4673115471358722 1.0 12.035816556110133 -4.442857685307431 1.2453786871832528 1.15009405043726 5.926668618805496e-42 0.5090951190008506 0.15380902255699946 2.4689907137173384 1.9011553134039927 0.044407086363884685 4.4684962761149745 3.606968210083306e-05 4.442857685307431 -1.15009405043726 RPLS(ph)SSHEASEGQAK ddPTM_A459_Selumetinib_30min_R1 2 RPLSSSHEASEGQAK 15 1 A0A0J9YVR0;Q8IZ21-3;Q8IZ21;Q8IZ21-2 A0A0J9YVR0;Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 RPLS(0.906)S(0.093)S(0.002)HEASEGQAK;RPLS(0.673)S(0.24)S(0.087)HEASEGQAK 114.06 0.0046832 10544100.0 4941.2 4177.4 5638.4 5022.8 5840.6 4860.9 6117.3 4831.700000000001 1898.58 3739.5 True False 5056.320346098495 3688.3080659794286 4872.736249514233 4145.66226963326 5312.318761241683 4812.003759344074 5655.867135933512 4703.547620426515 3221.7515932032024 4219.5012508145865 1.198321802872403 0.8741099591491744 1.1548133203120956 0.9825005428859461 1.258992104864556 1.1404200338642163 1.3404112950177776 1.1147164891866028 0.7635384851660453 1.0 12.042856765703526 -8.194760884139935 8.38201064422457 0.8825602571624773 1.1318922270759144 0.35752026133263803 0.1347632422736869 0.34508478169814316 40.42900241404208 0.09237344595479707 0.03461463683723453 6.386150010067322e-09 8.194760884139935 0.2493319699134371 RPLSS(ph)SHEASEGQAK ddPTM_A459_Selumetinib_30min_R2 2 RPLSSSHEASEGQAK 15 1 A0A0J9YVR0;Q8IZ21-3;Q8IZ21;Q8IZ21-2 A0A0J9YVR0;Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 RPLS(0.156)S(0.422)S(0.422)HEASEGQAK;RPLS(0.066)S(0.589)S(0.339)HEAS(0.005)EGQAK 76.156 0.019156 67181000.0 57777.0 62273.0 82373.0 96594.0 99638.0 81170.0 70031.0 77127.0 75890.0 97586.0 True False 54565.98563965632 67049.13886074543 77073.21086094137 83437.73056605588 87120.58366497823 92350.43071210294 73287.58026379395 77351.42680093784 91070.12054376733 94768.43862112203 0.5757822586674403 0.7075049440120404 0.8132793151639333 0.8804379578272301 0.9192995572426869 0.9744850928832317 0.7733332038611807 0.8162150598490258 0.9609752135714684 1.0 16.532119048102246 -5.016948316747596 1.2688997202046943 0.8958387253302929 0.5093956022312314 0.7248671757563847 0.06620105604645686 0.5360373651619018 1.0097378310145064 0.02102974625022648 0.24286071346283641 9.617267219456216e-06 5.016948316747596 -0.3864431230990615 RPMEEDGEEKS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 RPMEEDGEEKSPSK 14 2 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 RPMEEDGEEKS(0.894)PS(0.106)K;RPMEEDGEEKS(0.973)PS(0.027)K;RPMEEDGEEKS(1)PSK 147.07 0.003324800000000001 435641600.0 10449.6 14118.3 13098.9 13413.1 8846.599999999999 10809.3 9138.199999999999 9905.7 6791.5 10935.0 True False 10693.05534861792 12465.3228725804 11320.14132710733 11070.753880070446 8046.426591994088 10700.568256059147 8448.89821679297 9642.968657751706 11524.679468465662 12338.613765919912 0.8666334445246081 1.0102693146138075 0.9174564940491393 0.8972445438440272 0.6521337602947638 0.8672423384882053 0.6847526291915709 0.7815277178370101 0.9340335703105974 1.0 13.590892697426325 -6.0174055161591165 23.778659750906538 0.8019077662050609 0.9340040645301033 0.18370847114181144 0.10400399212622446 518.3666798971614 708171.9577458843 0.029148300214706584 0.038574270880359834 9.607148059638485e-07 6.0174055161591165 0.13209629832504244 RPMEEDGEEKS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 RPMEEDGEEKSPSK 14 2 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 RPMEEDGEEKS(0.729)PS(0.271)K;RPMEEDGEEKS(0.701)PS(0.299)K 79.393 0.04084 445125000.0 567370.0 513590.0 460180.0 431750.0 340864.0 371761.0 477300.0 423852.0 266410.0 405089.0 True False 535837.8467620651 552980.7015478661 430572.51980610035 372944.9051897074 298041.6169571765 422967.70323964674 499495.395752008 425085.3391475245 319699.44411734195 393393.02802237734 1.3620928908063543 1.4056698064217115 1.094509788266019 0.9480211356681523 0.757617943702406 1.0751784427038373 1.2697108493839278 1.080561445850902 0.8126718608219882 1.0 18.58561186386141 -5.35850496246165 3.6117273294248067 1.0016290477298997 1.3872553886439938 0.5629201454234423 0.13566192408234873 0.1863969496110835 4.462086608471449 0.04011525990685376 0.09458833288702709 4.380211060978805e-06 5.35850496246165 0.3856263409140941 RPMEEDGEEKSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 RPMEEDGEEKSPSK 14 2 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 RPMEEDGEEKS(0.168)PS(0.832)K 83.964 0.030181 32876000.0 99925.0 85274.0 74714.0 67945.0 65407.0 46762.0 72689.0 78846.0 40163.0 75268.0 True False 94371.56853146853 91814.24160087363 69906.98258245263 58690.77378833741 57189.98791400105 53203.041036828334 76069.18253052096 79075.42880634205 48196.72224798174 73094.81727025 1.29108426637901 1.2560978333308255 0.9563876782671042 0.8029402901623353 0.7824082479412353 0.7278633838035774 1.0406918762690656 1.0818199122651915 0.6593726347216423 1.0 16.157481496211687 -5.305961647791712 3.2327142102547035 0.8717804510247318 1.2882057652515302 0.6000138277647932 0.12972449560676566 0.1681260960632759 3.5251050041495358 0.036230999006428045 0.09559932629140919 4.943543411070696e-06 5.305961647791712 0.4164253142267984 RPMEFEAALLSPGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 RPMEFEAALLSPGSPK 16 1 B4DQP0;Q9H9L7-2;Q9H9L7 B4DQP0 AKIRIN1 Akirin-1 1 RPMEFEAALLS(0.025)PGS(0.975)PK 87.963 0.0073493 16243000.0 9181.3 10633.0 11220.0 12255.0 7976.3 9476.9 9464.5 9060.0 6519.0 9131.5 True False 9395.206426300108 9388.08341685241 9696.385627048401 10114.894304841044 7254.845073330145 9381.57099033673 8750.585145087332 8819.699368972457 11062.266871078207 10303.616973342256 0.9118357612290512 0.9111444496764065 0.9410661956995396 0.9816838427719625 0.7041066347963089 0.9105123972105074 0.8492731404638816 0.8559809037730126 1.0736294739700385 1.0 13.330863248365924 -8.259254469524937 24.97828544725884 1.036814746422182 0.8831532191257473 0.4203153615458768 0.07216054860650997 179.28050886758317 2049630.6087724238 0.05529700420984756 0.01863393728773456 5.504850519255129e-09 8.259254469524937 -0.15366152729643467 RPMS(ph)DPSWNR ddPTM_A459_Selumetinib_30min_R2 2 RPMSDPSWNR 10 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 RPMS(1)DPSWNR;RPMS(1)DPSWNR 115.24 0.0034441000000000003 20304200.0 53097.0 45882.0 48229.0 47780.0 63000.0 36194.0 33123.0 38108.0 37407.0 47708.0 True False 50146.08130413199 49401.001866117236 45125.99864776483 41272.281574902656 55085.376772854026 41179.394963580795 34663.28513197936 38218.887970881005 44889.44523890777 46330.546079729684 1.0823546352731566 1.066272816666215 0.9740010094011851 0.8908222558801202 1.1889645478829076 0.8888173882672495 0.7481734636222014 0.8249177099080718 0.9688952329993706 1.0 15.499676066493805 -6.970038282126511 24.94654986130516 0.8634190876908631 1.0308062842395826 0.37236185965783386 0.09813000765084764 201.36543795318647 167659.14287961012 0.034579380750686214 0.030495808913998744 1.0714248572732631e-07 6.970038282126511 0.16738719654871959 RPMS(ph)SPEMK ddPTM_A459_Selumetinib_30min_R2 2 RPMSSPEMK 9 1 P51610;A6NEM2;P51610-2;P51610-4;H7C1C4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 RPMS(0.5)S(0.5)PEMK;RPMS(0.5)S(0.5)PEMK 72.34 0.034761 50204000.0 144348.0 136777.0 129252.0 144377.0 133949.0 104274.0 115984.0 112251.0 88629.0 126888.0 True False 136325.71603082737 147267.35609262742 120936.06703893722 124712.60353578308 117121.1291007464 118636.79699487262 121377.48581793584 112577.63182584646 106357.2765011669 123224.41374538302 1.1063206704518425 1.195115088126319 0.9814294372609135 1.01207706934987 0.950470166916373 0.9627702286335098 0.9850116720273998 0.913598437225793 0.8631185433832255 1.0 16.91092859167123 -5.346305730767405 4.846050850717371 0.9562286450883797 1.1501639354007527 0.7410173142136735 0.045529038895044574 0.10204441395142619 4.1169267957578235 0.012529501813264564 0.027462779290631505 4.504994542872945e-06 5.346305730767405 0.193935290312373 RPMSS(ph)PEMK ddPTM_A459_Selumetinib_30min_R1 1 RPMSSPEMK 9 1 P51610;A6NEM2;P51610-2;P51610-4;H7C1C4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 RPMS(0.077)S(0.923)PEMK 108.98 0.020998 33621000.0 5500.4 6035.6 6173.4 6851.7 5451.0 4521.4 5089.3 5096.5 3060.5 4568.2 True False 5628.548618084711 5328.949146125687 5335.086188058877 5655.179217338173 4957.958012452215 4475.918821102738 4705.410003581063 4961.324264234891 5193.4449699240495 5154.572968036155 1.091952457165261 1.0338294130611498 1.0350200144885129 1.097118859778746 0.9618562086901938 0.8683394044197655 0.9128612656682948 0.9625092699240827 1.007541265227778 1.0 12.331637196752975 -6.358681931325053 5.720599110856127 0.9427544536946006 1.0598267158280554 0.6222198767318791 0.042591929422401344 0.15662459153842714 7.493968052587864 0.014003461792358538 0.015918297938921827 4.378426550483964e-07 6.358681931325053 0.11707226213345479 RPMSS(ph)PEMK ddPTM_A459_Selumetinib_30min_R2 1 RPMSSPEMK 9 1 P51610;A6NEM2;P51610-2;P51610-4;H7C1C4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 RPMS(0.156)S(0.844)PEMK 88.021 0.016299 156880000.0 115650.0 117570.0 103790.0 122210.0 125070.0 87865.0 84958.0 92675.0 84278.0 112150.0 True False 109222.63598363109 126587.24095286638 97112.26439800767 105564.78717599082 109357.58846001365 99967.60619094393 88908.71534108321 92944.66890682784 101135.95492406933 108911.93809930596 1.002852744058616 1.1622898569433597 0.8916585830054797 0.969267364241896 1.0040918412479387 0.9178755601593778 0.8163358112314207 0.8533928468161207 0.9286030226718903 1.0 16.73280257443013 -5.572478220993013 0.7637794307053085 0.8957964757344785 1.0964283153017258 0.32460681261137436 0.0760064838188747 1.2095887910878123 1.0859529297641823 0.035635058215321 0.17391878057695956 2.6762197969496943e-06 5.572478220993013 0.20063183956724728 RPNEDS(ph)DEDEEK ddPTM_A459_Selumetinib_30min_R1 4 RPNEDSDEDEEK 12 1 H0YE74;E9PLP8;Q12996 H0YE74 CSTF3 Cleavage stimulation factor subunit 3 1 RPNEDS(1)DEDEEK;RPNEDS(1)DEDEEK;RPNEDS(1)DEDEEK;RPNEDS(1)DEDEEK 178.22 0.00018629 11787480.0 2534.7980000000002 3913.54 2584.2200000000003 2191.8 2157.9310000000005 2720.1 2687.6800000000003 3148.0 1788.7119999999998 3201.26 True False 2593.853861541685 3455.340917444615 2233.2971181043704 1809.043275181606 1962.7465220636623 2692.7382636531947 2484.946133736418 3064.5048138548887 3035.3136216444314 3612.1729039130096 0.7180868498104851 0.9565823700469873 0.6182697167361715 0.5008185718966826 0.5433700363394703 0.745462173401554 0.6879366519372633 0.8483826481659168 0.8403013095957628 1.0 11.818651236630249 -8.188249306602456 1.1051148691737047 0.9837324789379964 0.6745506423558429 0.4240410272983509 0.11996559429717671 0.5164765951450957 1.233369728588127 0.12501474331273407 0.042291049963949896 6.482621920208285e-09 8.188249306602456 -0.3091818365821535 RPNEDS(ph)DEDEEK ddPTM_A459_Selumetinib_30min_R2 2 RPNEDSDEDEEK 12 1 H0YE74;E9PLP8;Q12996 H0YE74 CSTF3 Cleavage stimulation factor subunit 3 1 RPNEDS(1)DEDEEK;RPNEDS(1)DEDEEK 89.23200000000001 0.013379 56872300.0 42026.0 28349.0 31609.0 37134.0 38117.0 35934.0 48228.0 44104.0 40207.0 36726.0 True False 39690.363163407565 30523.277143597883 29575.311353277044 32076.28514027699 33328.40168969648 40883.5823236258 50470.69756196903 44232.33533818975 48249.52347744446 35665.624954392406 1.1128464232482065 0.8558178128836849 0.8292385564839146 0.8993613649359767 0.9344684617840102 1.1463021431954685 1.4151076176713202 1.240195156954408 1.3528298898209068 1.0 15.122246633096854 -6.870998614421595 3.3304583869010984 1.2735291835280789 0.9133144855430296 0.605764691993589 0.12418732759372107 0.14791753300404523 3.2315910078017835 0.044515343949555336 0.039078214742359674 1.345864647912066e-07 6.870998614421595 -0.36021469798504924 RPNEDS(ph)DEDEEKGAVVPPVHDIYR ddPTM_A459_Selumetinib_30min_R1 3 RPNEDSDEDEEKGAVVPPVHDIYR 24 2 H0YE74;E9PLP8;Q12996 H0YE74 CSTF3 Cleavage stimulation factor subunit 3 1 RPNEDS(1)DEDEEKGAVVPPVHDIYR;RPNEDS(1)DEDEEKGAVVPPVHDIYR;RPNEDS(1)DEDEEKGAVVPPVHDIYR 75.225 0.00016779 223794000.0 6360.6 7392.08 10235.02 9856.99 7040.77 7239.91 6535.65 7220.2699999999995 4778.02 6236.400000000001 True False 6508.789604426878 6526.611837115241 8845.160500940548 8135.651735118322 6403.933596648903 7167.083078712325 6042.6606586180005 7028.764984857698 8107.950967226437 7036.902687680197 0.9249509185088052 0.9274835999283685 1.256967858376974 1.1561410035357957 0.9100500434460378 1.0184996719167425 0.8587102773493147 0.9988435675205874 1.1522045034701658 1.0 12.780724846992566 -6.2661675881077 24.99248817085163 0.9845488887839973 1.070077255886826 0.0934175379160459 0.11611169115260127 1014.653470891923 5363274.048112942 0.03819351458004541 0.04477131023692099 5.417917802607751e-07 6.2661675881077 0.08552836710282863 RPNEDS(ph)DEDEEKGAVVPPVHDIYR ddPTM_A459_Selumetinib_30min_R2 4 RPNEDSDEDEEKGAVVPPVHDIYR 24 2 H0YE74;E9PLP8;Q12996 H0YE74 CSTF3 Cleavage stimulation factor subunit 3 1 RPNEDS(1)DEDEEKGAVVPPVHDIYR;RPNEDS(1)DEDEEKGAVVPPVHDIYR;RPNEDS(1)DEDEEKGAVVPPVHDIYR;RPNEDS(1)DEDEEKGAVVPPVHDIYR 70.17399999999999 0.0017424 176361800.0 296095.0 289334.0 281411.0 283234.0 235958.0 219495.0 232224.0 199261.0 150677.0 263119.0 True False 279639.2252621987 311524.98744455713 263305.32263712963 244657.04059409784 206314.8465487156 249728.44387277364 243022.8761431265 199840.81652056542 180816.61026713997 255522.07080473713 1.0943838408224675 1.2191705650453024 1.0304601939389426 0.9574790929941154 0.8074247594305687 0.977326315047005 0.9510836984756508 0.7820882786805459 0.7076359771885028 1.0 17.963088384250767 -5.689475340221166 1.9559419298432537 0.869677899009655 1.1572460386519678 0.5952078977998905 0.09225733412523113 0.23080533368390477 1.7889157119794898 0.028929824637879013 0.06225397702414042 2.0442060052571083e-06 5.689475340221166 0.28756813964231287 RPPEEDWR ddPTM_A459_Selumetinib_30min_R1 1 RPPEEDWR 8 1 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 0 96.034 0.028961 2468600.0 564.72 589.22 656.25 686.84 778.28 735.47 594.29 575.4 407.13 640.61 False True 577.8768772461633 520.2338484790534 567.1348545232186 566.8962875836 707.8847114164939 728.0718395533308 549.4622268343762 560.1385228373898 690.8698744012992 722.8385335698175 0.7994549963907636 0.7197096229912113 0.78459410806776 0.7842640662554615 0.9793123616702163 1.0072399377460801 0.7601451794784606 0.774915139168196 0.9557734436062262 1.0 9.497529606198992 -6.122214375483924 6.721925046131118 0.898477238193554 0.7665908020530681 0.39937173989248453 0.08366700414606254 0.29992529321018324 15.237163014012541 0.026566776055873893 0.03449152663491475 7.547195926832536e-07 6.122214375483924 -0.1318864361404859 RPPES(ph)PPIVEEWNSR ddPTM_A459_Selumetinib_30min_R1 3 RPPESPPIVEEWNSR 15 1 A0A3B3IU46;Q9BTL3 A0A3B3IU46 FAM103A1 RNMT-activating mini protein 1 RPPES(1)PPIVEEWNSR;RPPES(1)PPIVEEWNSR;RPPES(1)PPIVEEWNSR 104.68 0.0025252 89684800.0 1787.7799999999997 2298.3100000000004 1960.29 2319.83 2378.08 1738.84 2095.55 1941.25 990.21 2028.17 True False 1829.4317955856816 2029.2227967446684 1694.0933851022028 1914.7152391023576 2162.9830838841244 1721.348848340399 1937.4809763630165 1889.7617439313212 1680.3140479230485 2288.5053755487684 0.7994002614684687 0.8867022198967194 0.740261920816319 0.8366662624260699 0.9451509736416746 0.7521716429998033 0.8466141251245353 0.825762422986736 0.7342408131858202 1.0 11.160189965400505 -11.656825765153595 2.4194169292101178 1.3763288013211064 0.8215953383082553 0.425260654822874 0.0631929980169974 7265886.227147367 1832130.214188258 15030917.782560635 0.015430995360844642 2.2038104336633093e-12 11.656825765153595 -0.5547334630128511 RPPES(ph)PPIVEEWNSR ddPTM_A459_Selumetinib_30min_R2 3 RPPESPPIVEEWNSR 15 1 A0A3B3IU46;Q9BTL3 A0A3B3IU46 FAM103A1 RNMT-activating mini protein 1 RPPES(1)PPIVEEWNSR;RPPES(1)PPIVEEWNSR;RPPES(1)PPIVEEWNSR 114.21 0.0013208 58335000.0 24809.9 18923.800000000003 30503.399999999998 27861.699999999997 33920.6 23525.699999999997 20147.199999999997 23252.300000000003 19826.5 18772.3 True False 23431.06507989876 20375.19461039253 28540.844453590773 24066.888395886675 29659.190973988476 26766.151629958345 21084.08472091942 23319.960343374518 23792.35399869558 18230.294922707075 1.285281734565565 1.1176557865234442 1.5655722836409633 1.320159026385784 1.6269177816232656 1.4682237310719137 1.1565410658638198 1.2791872233689383 1.3050997857999862 1.0 14.154050280481366 -8.844676328580686 0.7022249628328959 1.0010591651152474 1.3794884889219552 0.3385451069336647 0.15195017806922798 1.4891910394117984 1.421904955523139 0.1689282671668847 0.06084055883292373 1.4299592829418736e-09 8.844676328580686 0.3784293238067078 RPPGGT(ph)SPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLR ddPTM_A459_Selumetinib_30min_R2 1 RPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLR 45 1 H3BUF6;Q8WWM7-7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 RPPGGT(0.499)S(0.499)PPNGGLPGPLAT(0.001)S(0.001)AAPPGPPAAASPCLGPVAAAGSGLR 75.50399999999998 7.644600000000002e-13 8537100.0 20990.0 15810.0 25136.0 24456.0 24753.0 16847.0 19228.0 22681.0 17242.0 22495.0 True False 19823.45982962747 17022.576162837588 23518.77712600751 21125.050611046867 21643.306845372314 19167.52132816062 20122.140099559183 22746.99795495831 20690.881781731987 21845.510900970898 0.9074386000625163 0.7792253630507235 1.0765954265213475 0.9670202132973685 0.9907439081413474 0.8774123624322625 0.9211109866359262 1.0412664669676985 0.9471457030932797 1.0 14.415049226035542 -5.250749050424275 24.99676410264552 0.9736228279349126 0.8433319851562882 0.436215306321295 0.060947366374657995 679.5236558610226 1588895.436481981 0.015559659453593182 0.040272043387338946 5.613722616109445e-06 5.250749050424275 -0.13029084277862446 RPPGPDLS(ph)PDGPR ddPTM_A459_Selumetinib_30min_R2 2 RPPGPDLSPDGPR 13 1 H0Y9P2;J3KPQ0;P22455-3;P22455-2;P22455 H0Y9P2 FGFR4 Receptor protein-tyrosine kinase;Fibroblast growth factor receptor 4 1 RPPGPDLS(1)PDGPR;RPPGPDLS(1)PDGPR 110.22 0.01018 11360000.0 46122.0 27107.1 43854.0 47916.0 42041.0 39412.0 48408.0 45576.0 49761.0 36795.0 True False 43558.72388099469 29186.127406935775 41032.481384625 41389.75814028959 36759.43372869141 44840.645253485265 50659.06791863228 45708.61861448704 59714.590438508596 35732.632745108865 1.2190180385450906 0.81679196758685 1.1483195676434335 1.1583181803460894 1.0287356655443503 1.2548934071929843 1.4177255921778271 1.2791841827200292 1.6711500343249244 1.0 15.124954593735254 -6.930047155223635 3.709216727985523 1.363694779332423 1.069039833672493 0.3197712458719919 0.18435117430623013 0.2493305417458345 6.878930708201711 0.06548517099107799 0.05624397424726747 1.1747699927631865e-07 6.930047155223635 -0.2946549456599301 RPPGPTTS(ph)PASTSLSSPGQR ddPTM_A459_Selumetinib_30min_R1 1 RPPGPTTSPASTSLSSPGQR 20 1 Q01970-2;Q01970 Q01970-2 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 1 RPPGPTT(0.219)S(0.779)PAS(0.001)TSLSSPGQR 164.69 2.01e-07 2881400.0 343.01 437.58 689.18 572.12 424.84 447.34 554.36 471.71 190.45 316.17 True False 351.0014656187253 386.3479301745771 595.593141394761 472.209982022493 386.4132970115939 442.84016575222245 512.5441788822033 459.1987184699774 323.1797400823508 356.75349925659776 0.9838767281894683 1.082954844114068 1.6694808674220627 1.3236309749069968 1.0831380710120606 1.2413057382058252 1.4366899832804494 1.287159675873831 0.9058908763496143 1.0 8.478783770380828 -8.257825377952527 24.147584886616315 0.9529454048425792 1.2720637159215447 0.3065535364419312 0.18649675854001385 229.49146337902735 1533431.266110346 0.14542666195574055 0.04994335857167638 5.522994643830069e-09 8.257825377952527 0.3191183110789655 RPPS(ph)PDVIVLS(ph)DNEQPSSPR ddPTM_A459_Selumetinib_30min_R1 1 RPPSPDVIVLSDNEQPSSPR 20 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 2 RPPS(1)PDVIVLS(0.924)DNEQPS(0.056)S(0.019)PR 82.65 0.0078922 2802900.0 699.58 724.54 938.3 881.63 954.99 733.06 795.12 686.07 504.37 759.06 True False 715.8788528542835 639.7105199704927 810.8840137129696 727.6698707447579 868.6113231171789 725.6860819652258 735.143458245215 667.8731949305666 855.8790522726981 856.4927448705228 0.835825939147335 0.7468954335009559 0.9467494249884768 0.8495925681831208 1.0141490728546547 0.8472763912027401 0.858318371811016 0.7797768269847165 0.9992834818490874 1.0 9.74229721543759 -14.522878745280336 0.06828163750754342 1.4051085605022147 0.7214210826249167 0.23242861523426372 0.07965008750450342 559.1825555802476 2.745914794392472 36.66768841283985 4.776745281788526 3.0000000000000132e-15 14.522878745280336 -0.683687477877298 RPPS(ph)PDVIVLS(ph)DNEQPSSPR ddPTM_A459_Selumetinib_30min_R2 4 RPPSPDVIVLSDNEQPSSPR 20 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 2 RPPS(1)PDVIVLS(0.99)DNEQPS(0.005)S(0.005)PR;RPPS(1)PDVIVLS(0.863)DNEQPS(0.074)S(0.063)PR;RPPS(1)PDVIVLS(0.945)DNEQPS(0.043)S(0.012)PR;RPPS(1)PDVIVLS(0.586)DNEQPS(0.187)S(0.226)PR 116.08 0.00065719 21540700.0 67849.3 67659.3 80452.0 79450.1 85854.0 61071.0 67118.8 64287.1 59710.7 70335.4 True False 64078.50752826785 72848.55075106105 75275.80590951469 68628.8593209328 75068.2529755018 69482.97590265899 70239.95719337916 64474.16481769763 71654.50845635441 68304.634248684 0.9381282578129378 1.066524278364972 1.102060010093166 1.004746750726581 1.0990213738967223 1.0172512695066176 1.0283336989646854 0.9439207972765015 1.0490431468452661 1.0 16.059695843581423 -7.315717927730887 2.641935509655811 0.9973675047850904 1.0444819416386284 0.09535000736329768 0.05117273463539577 0.5753082465945033 7.904927602471913 0.02370440180163612 0.015242570113886206 4.83372648420454e-08 7.315717927730887 0.047114436853538 RPPS(ph)PDVIVLSDNEQPS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 RPPSPDVIVLSDNEQPSSPR 20 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 2 RPPS(1)PDVIVLSDNEQPS(0.576)S(0.423)PR;RPPS(1)PDVIVLSDNEQPS(0.572)S(0.428)PR 183.69 2.2355999999999998e-13 17896300.0 56879.0 60346.0 61880.0 71375.0 67051.0 52280.0 54334.0 55341.0 46457.0 62774.0 True False 53717.89288467754 64974.34415702699 57898.7081698498 61653.60187125739 58627.453936454585 59481.09544941166 56860.6386607785 55502.033147804235 55749.69811703531 60961.55151356064 0.8811766031369497 1.0658249756417981 0.9497577855604689 1.0113522431846704 0.9617119722324186 0.9757149214973694 0.9327295196568298 0.9104432510294302 0.9145058931880043 1.0 15.89561200043245 -7.250508943213904 4.992102918956274 0.9316527243323516 0.978686817960744 0.09396217093609849 0.04970873127392048 0.3309780390304209 25.368858876977864 0.018893194888823264 0.013672325228965316 5.6168271177911575e-08 7.250508943213904 0.04703409362839239 RPPS(ph)PDVIVLSDNEQPSSPR ddPTM_A459_Selumetinib_30min_R1 2 RPPSPDVIVLSDNEQPSSPR 20 1 Q86YP4-2;Q86YP4;Q86YP4-3;C9JMI3;C9JGN4;C9JHD7;C9JJK9 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 1 RPPS(1)PDVIVLSDNEQPSSPR;RPPS(1)PDVIVLSDNEQPSSPR 120.08 0.00012933 23511000.0 2637.4 2947.5 3411.7999999999997 3798.8999999999996 2831.5 2786.0 3020.5 2753.3 1641.58 2589.5 True False 2698.8462885129475 2602.405329744427 2948.496299675911 3135.4934291848717 2575.3913249419265 2757.975369485607 2792.661253181499 2680.2735400211754 2785.6413637405394 2921.887548865991 0.9236653510366586 0.8906589614492325 1.0091066991336635 1.073105441857878 0.8814135663576298 0.9439019549386836 0.9557730085353059 0.9173089296545351 0.9533704898471094 1.0 11.512684940621718 RPPS(ph)PEPSTK ddPTM_A459_Selumetinib_30min_R1 5 RPPSPEPSTK 10 1 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 RPPS(1)PEPSTK;RPPS(0.998)PEPS(0.002)TK;RPPS(1)PEPSTK;RPPS(1)PEPSTK;RPPS(0.999)PEPS(0.001)TK 111.72 0.015434 9357346000.0 26204.399999999998 30640.000000000004 31886.100000000002 33352.5 31569.499999999996 26633.5 28717.800000000003 26222.7 15832.699999999999 23558.300000000003 True False 26814.911535113602 27052.654555850437 27556.142757809976 27528.111978964556 28714.04429904792 26365.59117128315 26551.593225166576 25527.188812665994 26866.935525344365 26582.237282274444 1.0087529973631795 1.0176966772428022 1.0366374532434466 1.0355829604049482 1.0801966739720215 0.991849967002749 0.9988471979697396 0.9603100198675912 1.0107100933622228 1.0 14.698174913065303 -6.94491105651086 24.999994389450393 0.9900434114722081 1.034928311355196 0.5090192504010544 0.02126611692637842 73.66475258049927 33429.55355600633 0.007654392814309552 0.006750539307408213 1.1352432896376408e-07 6.94491105651086 0.04488489988298783 RPPS(ph)PEPSTK ddPTM_A459_Selumetinib_30min_R2 3 RPPSPEPSTK 10 1 A0A087WUZ3;Q01082;Q01082-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 RPPS(1)PEPSTK;RPPS(1)PEPSTK;RPPS(0.999)PEPSTK 75.102 0.031208 713284000.0 289397.0 266728.0 296688.0 290919.0 296623.0 215237.0 218378.0 242177.0 216178.0 248187.0 True False 273313.4732879799 287185.1799343031 277599.41708947025 251295.33033673317 259358.56689673493 244883.9430230492 228533.0097077979 242881.69497543937 259419.64051799462 241021.1964427328 1.1339810660715886 1.1915349528295076 1.1517635012463667 1.0426275117941401 1.0760819825170818 1.0160265845383196 0.9481863548963748 1.0077192320018569 1.0763353777460538 1.0 17.878800503290833 -5.920928031421552 1.3301583239704875 1.0107070613201767 1.1717874788695903 0.7289567145330786 0.037756781763988445 0.23221980543703738 0.8332652562372579 0.013981973231930437 0.02818238072647022 1.1996980931787581e-06 5.920928031421552 0.1610804175494136 RPPS(ph)PPGPEER ddPTM_A459_Selumetinib_30min_R2 1 RPPSPPGPEER 11 1 F5H1N7;Q6ZU35 F5H1N7 KIAA1211 Uncharacterized protein KIAA1211 1 RPPS(1)PPGPEER 81.703 0.043694 0.0 11531.0 12062.0 15564.0 12718.0 19962.0 10806.0 7742.8 14141.0 10117.0 14729.0 True False 10890.153182250331 12987.116614557055 14562.62918480192 10985.78646022629 17454.195097455744 12294.428412898667 8102.855542067133 14182.14796883142 12140.682692598439 14303.73549946211 0.7613502908145816 0.9079527942225606 1.0180997254423185 0.7680361861165156 1.2202543243415056 0.8595257101448078 0.5664852752885314 0.9914995959876871 0.8487770689729958 1.0 13.80410434353074 -6.9818075407029925 24.998809322970438 0.8312710508224687 0.9400473955228241 0.05238909207574738 0.16483909626197601 628.8619735540442 864135.5108078052 0.05742269880041407 0.05063368113921613 1.0427794387989024e-07 6.9818075407029925 0.10877634470035547 RPPSQSLTSSSLSSPDIFDSPS(ph)PEEDKEEHISLAHR ddPTM_A459_Selumetinib_30min_R2 1 RPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHR 36 2 Q5JPT2;Q96B97-2;Q96B97;Q96B97-3 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 RPPSQSLTSSSLSS(0.001)PDIFDS(0.229)PS(0.769)PEEDKEEHISLAHR 65.73 2.1828e-05 8642300.0 19715.0 15626.0 25656.0 39062.0 34830.0 22877.0 17238.0 21056.0 20443.0 36633.0 True False 18619.31922539809 16824.463954490824 24005.320892140728 33741.688214291506 30454.344015849325 26028.099093270655 18039.601156449 21117.26947399155 24532.171225144797 35575.310106035424 0.5233775663487269 0.4729252929726822 0.6747747474467742 0.9484580208498916 0.8560528053045048 0.7316337936532824 0.5070820493955033 0.5935934053996893 0.6895841849874097 1.0 15.118588712168798 -5.368056849362137 4.575655217221284 0.7406950842166224 0.49945023471298156 0.3368224344173647 0.1431803000866448 0.28014403376128516 9.394891602584188 0.04128293562414425 0.09064426695407386 4.28492426855917e-06 5.368056849362137 -0.2412448495036409 RPPTPAPWPSSGLGTPLT(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 RPPTPAPWPSSGLGTPLTPPK 21 1 M0R0S1;M0R2P6;Q8TBC3;M0R1G0;M0QZE8;M0R0K4;M0QYB1;M0R0E3;M0R0S2 M0R0S1 SHKBP1 SH3KBP1-binding protein 1 1 RPPTPAPWPSSGLGTPLT(1)PPK;RPPTPAPWPSS(0.001)GLGT(0.083)PLT(0.916)PPK 91.733 0.00080032 27859000.0 97995.0 99791.0 114845.0 108399.0 120977.0 92539.0 108575.0 99156.0 74830.0 104721.0 True False 92548.83020506648 107444.64882136158 107455.99773378168 93634.86920129496 105778.78771189784 105285.40726459635 113623.95263728108 99444.52754384051 89798.09092489281 101697.43263216596 0.9100409696654833 1.0565128935946986 1.0566244884710525 0.9207200887751724 1.040132331506282 1.0352808772017668 1.1172745436775449 0.9778469816787403 0.8829927029690865 1.0 16.63392373302657 -7.9983285749776165 24.998569184296176 0.9378041650056799 1.0219339574127744 0.19260692090536524 0.06452533643636472 74.34372869928866 1111922.7905673706 0.03521914291891865 0.01672749693277336 1.0038560137050591e-08 7.9983285749776165 0.0841297924070945 RPQQPNPPSAPLVPGLLDQS(ph)NPLSTPMPK ddPTM_A459_Selumetinib_30min_R1 1 RPQQPNPPSAPLVPGLLDQSNPLSTPMPK 29 1 Q8WUA4;A0A087WZD8;Q8WUA4-2 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 RPQQPNPPSAPLVPGLLDQS(0.901)NPLS(0.076)T(0.023)PMPK 63.701 0.00049515 9405200.0 870.94 828.09 1004.5 1070.3 954.38 789.79 574.13 880.82 508.65 747.58 True False 891.2312074457665 731.1368378314037 868.0944173235398 883.3921970192873 868.0564975094743 781.8454296719448 530.822911865285 857.4577922934119 863.1418996738656 843.5391750458535 1.0565380172145775 0.866749120207322 1.0291097829289926 1.0472450161799154 1.0290648296948248 0.9268632125229332 0.6292806873331405 1.0165002618245937 1.0232386653849792 1.0 9.720311260459448 -6.885065043894657 6.19205990382406 0.8996972664033901 1.0010181065754493 0.11212675781731174 0.11707584741238516 0.4524656028366087 22.836478793032082 0.04318099789412049 0.03808655413322617 1.3029716189486352e-07 6.885065043894657 0.10132084017205922 RPQS(ph)PGAS(ph)PSQAER ddPTM_A459_Selumetinib_30min_R2 1 RPQSPGASPSQAER 14 1 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 2 RPQS(1)PGAS(0.978)PS(0.022)QAER 94.973 0.031408 13656000.0 41090.0 30025.0 47272.0 49521.0 53100.0 46667.0 45686.0 44634.0 49927.0 40052.0 True False 38806.38229630268 32327.82095440849 44230.570985862025 42776.15437151015 46429.103279976975 53094.95564915248 47810.489525091594 44763.87755044355 59913.795076936134 38895.5946924066 0.9977063624605967 0.8311435063549676 1.1371614532608483 1.099768616723609 1.1936853941210237 1.3650634749008723 1.2292006306417371 1.150872686340044 1.540374830382342 1.0 15.247319144649934 -5.710558473300891 1.1708524762095642 1.262502327271197 0.9056576387895755 0.42254127180275247 0.14351489283571967 0.4856689728875684 1.2762621613875098 0.048820234280354195 0.14221672123458018 1.9473388430741988e-06 5.710558473300891 -0.35684468848162154 RPQS(ph)PGASPS(ph)QAER ddPTM_A459_Selumetinib_30min_R1 1 RPQSPGASPSQAER 14 1 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 2 RPQS(0.988)PGAS(0.18)PS(0.832)QAER 103.67 0.02261 4177900.0 780.47 969.66 628.07 788.5 985.52 748.69 761.78 915.8 384.78 856.32 True False 798.6534324697425 856.1317564172956 542.7815437415586 650.8032769781445 896.379890007688 741.15885835613 704.3183212874034 891.5100090623588 652.9435567807134 966.2370132631487 0.826560586592054 0.8860473617399434 0.561747828215038 0.6735441388032423 0.9277018761478188 0.767056993452475 0.7289291463890409 0.922661828128045 0.6757592058863597 1.0 9.916233308357604 -14.522878744932187 0.34404478253663234 3.4784431955533544 0.7685888265599278 0.2564851441261019 0.1136437395319494 601.0176073464008 5.0114704916778985 1096.1576770582544 0.09132404600458184 3.0000000024049358e-15 14.522878744932187 -2.7098543689934265 RPQS(ph)PGASPS(ph)QAER ddPTM_A459_Selumetinib_30min_R2 2 RPQSPGASPSQAER 14 1 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 2 RPQS(1)PGAS(0.385)PS(0.615)QAER;RPQS(0.93)PGAS(0.081)PS(0.989)QAER 113.14 0.011396 12105500.0 23127.8 18802.4 22755.5 26800.9 27515.6 19764.3 24502.8 26151.7 20443.9 21384.3 True False 21842.449463918925 20244.483620755065 21291.43590431509 23150.57118586874 24058.84433541497 22486.652922547928 25642.22875137709 26227.79711735302 24533.25125029292 20766.879695916054 1.0517925554417493 0.9748447488110734 1.0252592693789329 1.1147833244501077 1.1585199455913593 1.0828132705449283 1.2347656040218602 1.2629628283786367 1.1813643459935654 1.0 14.341996841499656 -5.960655826141019 1.3772842752945662 1.17377382344476 1.0040456437518397 0.39294245448607934 0.07312813917603626 0.3899403001123651 1.5012664000982032 0.02592993933795607 0.04905121031695112 1.0948236589268452e-06 5.960655826141019 -0.1697281796929202 RPQS(ph)PGASPSQAER ddPTM_A459_Selumetinib_30min_R1 3 RPQSPGASPSQAER 14 1 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 RPQS(0.999)PGAS(0.001)PS(0.001)QAER;RPQS(1)PGASPSQAER;RPQS(1)PGASPSQAER 115.04 0.0051279 13362600.0 1205.83 1576.6 1862.77 1678.3600000000001 1377.99 1494.1200000000001 1379.85 1131.63 742.6200000000001 1121.54 True False 1233.923492863261 1392.0109390585442 1609.816065463186 1385.2659327191348 1253.3510478038938 1479.0905093524177 1275.7668035763913 1101.6154963477154 1260.1719011811786 1265.5005837247197 0.9750477469014525 1.0999686266137225 1.2720784851201334 1.0946387149359602 0.9903994229026222 1.1687790020602309 1.0081123785984003 0.8704978176346273 0.9957892689959436 1.0 10.305492457568262 -7.492333898196213 6.837616562950592 0.9474889102213515 1.1019212833317795 0.37262438727072045 0.08547035194342117 0.20205759953042104 33.53554277433618 0.038311381074898246 0.02478260495223512 3.218593291895949e-08 7.492333898196213 0.154432373110428 RPQS(ph)PGASPSQAER ddPTM_A459_Selumetinib_30min_R2 2 RPQSPGASPSQAER 14 1 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 RPQS(0.999)PGASPSQAER;RPQS(1)PGASPSQAER 97.214 0.0057768 13064100.0 1683.3 2920.8 2916.3 3334.45 3427.8 3873.65 2052.15 3092.2 2214.66 5117.0 True False 1589.748924783799 3144.815968147754 2728.66843302736 2880.2921577529105 2997.169119079193 4407.210126006376 2147.57904125808 3101.1977900587312 2657.6538827705926 4969.2589144373405 0.31991670230042807 0.6328541181484877 0.5491097324592357 0.5796220739041609 0.6031420722255839 0.8868948472783282 0.4321729010775938 0.6240765159264948 0.5348189596338458 1.0 12.278814997579174 -14.522878745280336 0.2854569332143503 4.119339718605658 0.5579270784650956 0.46035434049690305 0.1384492601452232 223.01339218620188 2.1156917334716265 413.86216944385126 0.15107844765389342 3.0000000000000132e-15 14.522878745280336 -3.561412640140562 RPQYS(ph)NPPVQGEVMEGADNQGAGEQGRPVR ddPTM_A459_Selumetinib_30min_R1 1 RPQYSNPPVQGEVMEGADNQGAGEQGRPVR 30 2 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 RPQY(0.464)S(0.536)NPPVQGEVMEGADNQGAGEQGRPVR 44.933 0.015738 10420000.0 562.87 548.43 609.73 698.43 815.19 371.47 719.63 630.01 257.59 306.36 True False 575.9837758456365 484.21956064181023 526.9320150071503 576.4623116548448 741.4562084334838 367.73334906777404 665.3477297225631 613.3000882391095 437.1114163707677 345.6842901991058 1.6662133402529913 1.400756627855178 1.5243157700445402 1.6675976548509521 2.144894140275865 1.0637838035855447 1.9247265455405536 1.7741624529302835 1.264481576871781 1.0 8.433311230844419 -9.919965639680012 9.162272143602255 0.9999998402980311 1.611559783684941 0.26928915125910013 0.297935753710389 0.0 0.0 0.27799712914829194 0.06742420747628719 1.2023595586096105e-10 9.919965639680012 0.6115599433869098 RPQYS(ph)NPPVQGEVMEGADNQGAGEQGRPVR ddPTM_A459_Selumetinib_30min_R2 1 RPQYSNPPVQGEVMEGADNQGAGEQGRPVR 30 2 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 1 RPQY(0.452)S(0.548)NPPVQGEVMEGADNQGAGEQGRPVR 75.10600000000002 1.8326e-05 9840200.0 10866.0 9634.6 13620.0 15741.0 12411.0 5683.3 11537.0 11769.0 6894.3 14324.0 True False 10262.11122004441 10373.542839878237 12743.704028334758 13597.048645260416 10851.819224252251 6466.122987139271 12073.493360131803 11803.245841537171 8273.352642836959 13910.428901778487 0.7377278797444103 0.7457385328033955 0.9161258878729066 0.9774715604579235 0.7801211091963395 0.4648399436707921 0.8679454418970628 0.848517750594167 0.5947589899100226 1.0 13.763879282889658 -5.038036038005099 24.762599017495464 0.7983367367003357 0.7397300101582835 0.024428460380842787 0.15716073763941718 2372.1348610981336 1544332.020817246 0.04130272700673829 0.10933296223399555 9.161444647747977e-06 5.038036038005099 -0.05860672654205212 RPQYSNPPVQGEVMEGADNQGAGEQGRPVR ddPTM_A459_Selumetinib_30min_R1 2 RPQYSNPPVQGEVMEGADNQGAGEQGRPVR 30 2 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 0 ; 69.639 0.00015221 114375000.0 2210.0 2225.29 2770.1 2896.9 2602.3 2317.54 2178.91 2176.3999999999996 1255.95 2013.52 False True 2261.4887000885756 1964.7520122907456 2393.9356350701214 2391.010796547857 2366.92242447338 2294.2276517579576 2014.5530644494947 2118.6748020564723 2131.255419041368 2271.974905345685 0.9953845417779763 0.8647771626649218 1.0536804915571372 1.0523931364391812 1.04179074289258 1.0097944507925307 0.8866968819547666 0.9325256177220462 0.938062922273824 1.0 11.149731184586868 -7.2378651175504976 24.41902162670569 0.9336984872650639 1.0030046944553141 0.22878641104572817 0.05687538818854785 881.9937810680979 913599.789711788 0.023189221197543092 0.01795103577880732 5.782756193876312e-08 7.2378651175504976 0.06930620719025027 RPRPS(ph)TPAEEDEDDPEQEK ddPTM_A459_Selumetinib_30min_R1 1 RPRPSTPAEEDEDDPEQEK 19 2 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 1 RPRPS(0.5)T(0.5)PAEEDEDDPEQEK 77.899 0.0088494 4072300.0 1225.9 1573.6 1197.2 1435.4 1195.1 1419.1 1394.9 1499.7 1069.7 1520.6 True False 1254.4610848138402 1389.3621804532079 1034.6268157488719 1184.7343357950895 1087.0034160120417 1404.8251424397067 1289.6815699595666 1459.9230842878574 1815.2027722031546 1715.7838218982915 0.7311300344503436 0.809753631384669 0.6030053451630007 0.6904916112825537 0.6335316851335117 0.8187658168296811 0.7516573786857961 0.850878220003638 1.0579437508595162 1.0 10.744652078337616 -7.969147619808416 1.590644463997318 1.0368346374823223 0.7094533265366144 0.772873238218263 0.06653044875522697 0.18561771932266802 0.8466412656849753 0.059267690806556104 0.02008100358342674 1.0736244176748422e-08 7.969147619808416 -0.3273813109457079 RPS(ph)ALPPK ddPTM_A459_Selumetinib_30min_R2 1 RPSALPPK 8 1 Q8N4B1-2;Q8N4B1;Q8N4B1-4 Q8N4B1-2 FAM109A Sesquipedalian-1 1 RPS(1)ALPPK 75.652 0.029624 39498000.0 108640.0 93522.0 114990.0 115310.0 118670.0 91646.0 89320.0 98422.0 87821.0 101270.0 True False 102602.22372037775 100694.83667937334 107591.6685916457 99604.57907915518 103761.6136767396 104269.40462044338 93473.55698422233 98708.39172536075 105387.65392376066 98346.07196894058 1.0432772927909244 1.0238826489295327 1.0940108378260909 1.0127967196352494 1.0550661719311916 1.0602294787469855 0.9504554184303663 1.0036841304300856 1.0716000325569073 1.0 16.585579810659254 RPS(ph)ASSPNNNTAAK ddPTM_A459_Selumetinib_30min_R1 2 RPSASSPNNNTAAK 14 1 O75151;E7ET14;A0A087WW48 O75151 PHF2 Lysine-specific demethylase PHF2 1 RPS(0.476)AS(0.476)S(0.049)PNNNTAAK;RPS(0.99)AS(0.004)S(0.006)PNNNTAAK 76.262 0.021864 4708000.0 1505.33 2589.0 1979.1 2939.8 2183.94 2076.38 2351.3 1790.9 1354.02 1607.8799999999999 True False 1540.4012601377083 2285.8786764065544 1710.349090418136 2426.4191168805933 1986.4030126059238 2055.493502402198 2173.9395479575087 1743.39951433695 2297.673046291966 1814.267060077484 0.8490487944326788 1.2599460833009495 0.9427217900021235 1.337410114681223 1.094879059602773 1.1329608234823 1.1982467167014892 0.960938746395193 1.2664469839373242 1.0 10.825171120843269 -4.744613170408459 24.91599959241269 1.1327439979688962 0.8490479266756327 0.3049891923587297 0.12841961271154972 1161.902463740134 1720431.4920594795 0.029075758445844018 0.8087901628135957 1.800473897724396e-05 4.744613170408459 -0.2836960712932636 RPS(ph)ASSPNNNTAAK ddPTM_A459_Selumetinib_30min_R2 1 RPSASSPNNNTAAK 14 1 O75151;E7ET14;A0A087WW48 O75151 PHF2 Lysine-specific demethylase PHF2 1 RPS(0.431)AS(0.431)S(0.138)PNNNTAAK 117.53 0.001279 1527600.0 5735.0 5073.9 6130.2 5856.0 4630.0 4518.2 5968.1 5859.5 5691.1 8483.5 True False 5416.2716590239925 5463.051814840075 5735.789606057098 5058.402697836542 4048.338007274831 5140.54103786403 6245.628475565799 5876.550174907559 6829.47902262005 8238.559312219892 0.6574294671873364 0.6631076633431493 0.696212697959151 0.6139911732302074 0.49138907105640545 0.6239611615394081 0.7580971670983704 0.7132982785219658 0.8289652066339057 1.0 13.008176358133941 -8.406780498799058 0.8994620376132199 0.9969743520890308 0.6276663205738043 0.7934684907425031 0.05922853468684533 0.27825392541023297 0.49718362884318584 0.06298336059404759 0.0223160512367473 3.9193992140656654e-09 8.406780498799058 -0.3693080315152265 RPS(ph)DSGPPAER ddPTM_A459_Selumetinib_30min_R1 2 RPSDSGPPAER 11 1 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 RPS(0.5)DS(0.5)GPPAER;RPS(0.997)DS(0.003)GPPAER 115.12 0.0079626 21553000.0 1811.63 2271.2 2115.41 2791.0 2572.7 2458.5 2339.8 2367.3 1598.37 1954.59 True False 1853.8374541816604 2005.2868481477656 1828.1489411153698 2303.604243558656 2339.9997392470773 2433.7697221393973 2163.307002216214 2304.5115139258824 2712.317149674072 2205.480665818874 0.8405593768800272 0.9092289400792465 0.8289117966203505 1.0444907902665062 1.0609930866831052 1.1035098878256373 0.9808777903809004 1.044902161076184 1.2298077202445183 1.0 11.106877397869596 -5.812397952463693 6.117608179685508 1.0673085115377194 0.8645983833567883 0.6692125887489959 0.06666476541631644 0.11312764390835353 9.34153878833128 0.01870660403114326 0.028446279353556276 1.540288409939172e-06 5.812397952463693 -0.20271012818093115 RPS(ph)DSGPPAER ddPTM_A459_Selumetinib_30min_R2 1 RPSDSGPPAER 11 1 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 RPS(0.854)DS(0.146)GPPAER 85.287 0.018012 9090400.0 3940.8 3786.5 4859.2 5984.6 6476.2 3814.8 3641.5 4521.1 4384.4 3625.0 True False 3721.78611227232 4076.9123744835224 4546.5643622969355 5169.487155989169 5662.60185803742 4340.254072693489 3810.8369654953603 4534.2556524916035 5261.402510371516 3520.336831118893 1.0572244335748404 1.1581029231193565 1.2915140170981507 1.4684637874115345 1.6085397874377938 1.2329087473467693 1.0825205508201714 1.2880175591181853 1.494573605531732 1.0 11.781497759358793 -10.418339463919596 14.702689301857983 1.0000082328394013 1.2992842237272813 0.2145531708314763 0.1710272728008688 0.0 0.0 0.18023037184819451 0.04371228588673257 3.816458428257002e-11 10.418339463919596 0.29927599088787993 RPS(ph)EGNEPSTK ddPTM_A459_Selumetinib_30min_R1 1 RPSEGNEPSTK 11 1 F2Z329;A0A087WWU1;Q96Q45-2;Q96Q45;Q96Q45-5;Q96Q45-3 F2Z329 TMEM237 Transmembrane protein 237 1 RPS(1)EGNEPSTK 131.08 0.0040776 4094700.0 1270.0 1152.9 1584.5 788.82 1322.0 897.91 1618.1 1491.4 611.49 1168.6 True False 1299.588529010178 1017.9179320313312 1369.333603035489 651.067394985288 1202.4253334180576 888.8778406370501 1496.0454142602168 1451.8432272500568 1037.6538685374471 1318.6011931279386 0.9855811869298712 0.7719680046827978 1.038474415290953 0.4937561094123154 0.9118946196049673 0.6741066558027949 1.1345700444205966 1.1010480157431424 0.7869353326428908 1.0 10.364792576548545 -7.264264294219696 24.96757503956727 1.0140590121362032 0.8110652795840427 0.23680465701106657 0.16946430069762658 359.0225990196059 3173138.198355114 0.06657282816377787 0.0471559089359313 5.441713911524033e-08 7.264264294219696 -0.20299373255216047 RPS(ph)EGNEPSTK ddPTM_A459_Selumetinib_30min_R2 1 RPSEGNEPSTK 11 1 F2Z329;A0A087WWU1;Q96Q45-2;Q96Q45;Q96Q45-5;Q96Q45-3 F2Z329 TMEM237 Transmembrane protein 237 1 RPS(1)EGNEPSTK 110.25 0.0045838 4556800.0 48560.0 15692.0 33676.0 43952.0 25393.0 19491.0 57301.0 47218.0 35273.0 37435.0 True False 45861.22960108197 16895.52594226739 31509.322823656472 37965.66177857097 22202.90432369973 22175.708328318313 59965.61003977747 47355.39656263931 42328.5856099659 36354.15428218916 1.2615127626157039 0.4647481498571112 0.8667323843947513 1.044328015001337 0.6107391235498362 0.6099910386082826 1.6494843910907913 1.302613071261568 1.164339714284146 1.0 15.149832613566707 -7.250296941148778 24.99412041599385 1.3043270611488649 0.7982137283682625 0.4312798002464704 0.26325556801690025 643.0055916427145 1442357.9371990277 0.09885504293655546 0.07584525743569473 5.619569656981485e-08 7.250296941148778 -0.5061133327806023 RPS(ph)EGPQPLVR ddPTM_A459_Selumetinib_30min_R2 1 RPSEGPQPLVR 11 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 RPS(1)EGPQPLVR 68.277 0.037178 2951700.0 11960.0 12424.0 13965.0 11021.0 12538.0 7014.2 10776.0 10571.0 6152.1 11257.0 True False 11295.31107967339 13376.88085054359 13066.507103942355 9519.920787714567 10962.86434885784 7980.342381431963 11277.105352238905 10601.759859876745 7382.6919040362645 10931.981160801477 1.0332355053972007 1.2236465333940316 1.1952551794357817 0.8708321618637527 1.0028250312182296 0.7299996463629914 1.031570141437394 0.9697930964143263 0.6753297316782975 1.0 13.416267258313757 -5.762662216029015 24.999805155087238 0.8989682025245783 1.1580058550915542 0.4831125816906491 0.12008878701731622 26.090348515022292 533414.7161033818 0.03235626844446507 0.05116988973012433 1.7271807300089075e-06 5.762662216029015 0.25903765256697586 RPS(ph)PGEMR ddPTM_A459_Selumetinib_30min_R1 2 RPSPGEMR 8 1 A0A0G2JHC2;Q6NYC8;Q6NYC8-3;Q6NYC8-2 A0A0G2JHC2 PPP1R18 Phostensin 1 RPS(1)PGEMR;RPS(1)PGEMR 111.27 0.005992100000000001 9871900.0 2090.27 2401.2 2271.3999999999996 1801.6799999999998 2099.07 1655.8000000000002 1903.87 1513.0 991.98 1702.08 True False 2138.9692240426016 2120.0663877124057 1962.9563559071064 1487.0504097222365 1909.2094891209088 1639.1441553461113 1760.259553085469 1472.8703250833692 1683.3176086473632 1920.558547663188 1.11372247758089 1.1038801135700684 1.0220757697262108 0.7742801756976291 0.9940907510702613 0.8534726303139868 0.9165352210830747 0.7668968628295466 0.8764729462142749 1.0 10.90731022933599 -5.566030539421421 5.462427421918992 0.8783809615729088 1.0992960751901022 0.6138360722544884 0.07346276461321272 0.10987076158606736 7.816460076131103 0.019311427596206545 0.034726247714288644 2.7162482565874513e-06 5.566030539421421 0.2209151136171934 RPS(ph)PGEMR ddPTM_A459_Selumetinib_30min_R2 4 RPSPGEMR 8 1 A0A0G2JHC2;Q6NYC8;Q6NYC8-3;Q6NYC8-2 A0A0G2JHC2 PPP1R18 Phostensin 1 RPS(1)PGEMR;RPS(1)PGEMR;RPS(1)PGEMR;RPS(1)PGEMR 121.05 0.0036377 23545400.0 19173.2 16668.100000000002 18918.6 24896.9 25788.1 17965.7 17935.8 18405.800000000003 19329.1 16554.4 True False 18107.630300400826 17946.489673611195 17701.39787301424 21505.899270451948 22548.3683294609 20440.31209861314 18769.850239113464 18459.357830755784 23195.46010017836 16076.43145850333 1.1263463752599854 1.1163229675649649 1.1010775568387359 1.337728421009552 1.4025729769484607 1.2714458523568435 1.1675383487661686 1.1482248332537783 1.4428239351531928 1.0 13.972659581559256 -5.746024233978706 24.97192265264993 1.2625327132526116 1.1147563031550785 0.20946905730646903 0.12214237517886893 355.1772780281525 575368.4647328578 0.032806933057485596 0.056556809183270114 1.7946334820578554e-06 5.746024233978706 -0.14777641009753317 RPS(ph)PPEPWDEEDGASCSTFFGSEER ddPTM_A459_Selumetinib_30min_R1 4 RPSPPEPWDEEDGASCSTFFGSEER 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 RPS(1)PPEPWDEEDGASCSTFFGSEER;RPS(1)PPEPWDEEDGASCSTFFGSEER;RPS(1)PPEPWDEEDGASCSTFFGSEER;RPS(1)PPEPWDEEDGASCSTFFGSEER 153.88 7.488e-11 74127000.0 6367.07 7480.7 5316.62 6285.01 6147.0 5551.620000000001 6645.73 6452.000000000001 3186.54 6602.4 True False 6515.410342838446 6604.856166316919 4594.652206103213 5187.4509877494065 5591.004935340992 5495.775743267653 6144.43723559208 6280.87200095036 5407.325644326666 7449.882352822094 0.8745655346316094 0.8865718750330239 0.6167415790616761 0.6963131418826158 0.7504823124116934 0.737699668664673 0.824769700324798 0.8430833808497795 0.7258269846742365 1.0 12.863001927640873 -11.183556018359978 6.818754880905314 1.0011105258020074 0.7712889467891346 0.4161028771484554 0.08068769716192352 0.0014641904542359468 7.286268591146834e-05 0.08397453099004752 0.020274563830282345 6.553057544319023e-12 11.183556018359978 -0.2298215790128728 RPS(ph)PPEPWDEEDGASCSTFFGSEER ddPTM_A459_Selumetinib_30min_R2 3 RPSPPEPWDEEDGASCSTFFGSEER 25 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 RPS(1)PPEPWDEEDGASCSTFFGSEER;RPS(1)PPEPWDEEDGASCSTFFGSEER;RPS(1)PPEPWDEEDGASCSTFFGSEER 131.94 2.8605e-08 31803300.0 53289.0 50905.0 67167.0 63274.0 76956.0 59631.0 67123.0 66387.0 68911.0 58039.0 True False 50327.410712768884 54809.24981462665 62845.54834590017 54655.9720462618 67288.09928463111 67844.62897367762 70244.35250170129 66580.17517904044 82695.12553421504 56363.2632665681 0.8929115845324133 0.9724286110867677 1.1150090449638148 0.9697091488079438 1.1938290188485783 1.2037029980469514 1.246279019890723 1.1812689918990638 1.4671812940125788 1.0 15.782467521399369 -5.966341386462696 0.7673350829453367 1.2471561135548215 0.9138399836712018 0.46388755521615244 0.11871342403345272 0.703796454282254 0.8091001977263665 0.05873840027519842 0.15299317372954038 1.0805842010454438e-06 5.966341386462696 -0.3333161298836197 RPS(ph)PPPQPSSVK ddPTM_A459_Selumetinib_30min_R1 1 RPSPPPQPSSVK 12 1 H3BLZ3;Q8IX03-2;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 RPS(1)PPPQPSSVK 84.169 0.016962 2523300.0 2980.0 3455.2 2674.8 2742.4 3411.8 3051.7 2583.0 2687.7 1720.7 2406.5 True False 3049.4282019293923 3050.6635777210986 2311.5768516246935 2263.49132122367 3103.2032924022155 3021.0026687219056 2388.1622304147686 2616.413465120006 2919.9022250443727 2715.397716295041 1.1230134663625302 1.123468418425093 0.8512848183354403 0.8335763515011114 1.1428172284965705 1.112545190191822 0.8794889294056117 0.9635470522122661 1.075312911814761 1.0 11.406947805455742 -7.550544640407893 0.005499003383996707 1.2219551512061009e-07 2.002690790636024 0.007076294544486328 0.11520729049132429 34256.92981793212 150.97818512164454 27350.29554643175 27621.900178146745 2.8148506664416724e-08 7.550544640407893 2.002690668440509 RPS(ph)PPPQPSSVK ddPTM_A459_Selumetinib_30min_R2 3 RPSPPPQPSSVK 12 1 H3BLZ3;Q8IX03-2;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 RPS(1)PPPQPSSVK;RPS(1)PPPQPSSVK;RPS(1)PPPQPSSVK 96.23 0.0088869 22462300.0 84508.0 83776.0 97051.0 104346.0 125971.0 99378.0 103361.0 103946.0 98711.0 106209.0 True False 79811.38367232763 90201.3498177027 90806.84432113911 90133.89479310982 110145.39678497151 113066.41743633559 108167.49130593597 104248.46565081328 118455.95821578387 103142.47020587786 0.7737974814159468 0.8745316031083608 0.8804020704553984 0.8738776045715966 1.06789566475493 1.0962159158167242 1.0487192239048366 1.0107229877540045 1.148469277295177 1.0 16.654278977259303 -6.228319586741009 4.480558932838591 1.0643521879441167 0.8513022361140843 0.8241683964029005 0.04789105686365446 0.0838827921510946 4.082904379114397 0.014368519969792236 0.01820122489570917 5.911264784939594e-07 6.228319586741009 -0.2130499518300324 RPS(ph)PQPSPR ddPTM_A459_Selumetinib_30min_R1 2 RPSPQPSPR 9 1 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RPS(1)PQPSPR;RPS(1)PQPSPR 97.452 0.010565 20704100.0 578.84 657.9000000000001 574.87 640.8 765.72 440.91999999999996 470.43 678.3199999999999 430.25 593.3 True False 592.325845773426 580.8727621505878 496.80581153487645 528.8963093057637 696.4607611988457 436.4847451233285 434.94508635463416 660.3287501061137 730.1028257833108 669.4558342313925 0.8847870396909453 0.8676789900822844 0.7421039389480609 0.7900391366564065 1.040338623680019 0.6519993146739248 0.6496994485887154 0.9863664133486003 1.0905914751218018 1.0 9.386845070063497 -7.939159015990104 8.25192327524759 1.0431599451102884 0.8068625261823872 0.4647455924350239 0.11026409377460274 0.22858313508992711 27.574974364691048 0.06328033060115046 0.03022269650529415 1.1503791029893091e-08 7.939159015990104 -0.23629741892790124 RPS(ph)PQPSPR ddPTM_A459_Selumetinib_30min_R2 5 RPSPQPSPR 9 1 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RPS(1)PQPSPR;RPS(1)PQPSPR;RPS(0.999)PQPS(0.001)PR;RPS(0.979)PQPS(0.021)PR;RPS(0.999)PQPS(0.001)PR 89.35600000000002 0.01539 114431900.0 16972.71 13391.279999999999 17747.18 15503.400000000001 19722.9 11964.900000000001 11845.3 13402.9 11229.5 15014.7 True False 16029.434725341425 14418.34811624818 16605.345760468586 13391.810175143275 17245.132977036872 13612.956368451898 12396.129921016665 13441.900220030457 13475.713778445617 14581.18659812437 1.099323063830988 0.9888322887317595 1.1388199203626261 0.9184307521903541 1.1826975027708084 0.9335972951750704 0.850145482851939 0.9218660038106594 0.9241849891818164 1.0 13.831820508649937 -6.966137118010195 23.549492418078785 0.913871290009321 1.0573346311587593 0.44586087014003883 0.07730136476640982 84.81777645892569 58984.8281129732 0.02519081621151545 0.02221602639072635 1.0810925684997658e-07 6.966137118010195 0.14346334114943826 RPS(ph)PSSQSSSLLTESEQCSLDGKK ddPTM_A459_Selumetinib_30min_R2 1 RPSPSSQSSSLLTESEQCSLDGKK 24 2 Q5D1E8 Q5D1E8 ZC3H12A Ribonuclease ZC3H12A 1 RPS(0.846)PS(0.075)S(0.075)QS(0.002)S(0.001)SLLTESEQCSLDGKK 58.107 0.004493100000000001 3196800.0 23692.0 24439.0 25729.0 30850.0 28464.0 19309.0 22422.0 21459.0 18748.0 24555.0 True False 22375.293486590468 26313.39271622946 24073.6241516171 26648.176780781643 24888.09784861139 21968.639480349833 23464.66742835012 21521.442137271308 22498.123862887787 23846.03334844811 0.9383235005853351 1.1034704318209774 1.0095441786834456 1.1175098345031835 1.043699699859352 0.9212701818929371 0.9840071547948746 0.9025166501611017 0.943474477877972 1.0 14.541461681651805 -6.750774527158913 24.284922589975498 0.9462705775835901 1.0482315595135727 0.4263167763394877 0.05320337492958997 128.59279908889422 292817.6481072453 0.016734425925328283 0.01655820605954477 1.7751108267045804e-07 6.750774527158913 0.1019609819299826 RPS(ph)PTSGDSR ddPTM_A459_Selumetinib_30min_R2 1 RPSPTSGDSR 10 1 Q8N1G1 Q8N1G1 REXO1 RNA exonuclease 1 homolog 1 RPS(0.857)PT(0.142)S(0.001)GDSR 105.25 0.02267 1628100.0 4877.6 3203.7 3375.2 3055.6 4086.5 3437.4 6494.3 6800.4 6153.8 5150.5 True False 4606.522518579847 3449.4134884808836 3158.0433066399037 2639.422008795992 3573.1173362264776 3910.8706483895867 6796.297818211316 6820.188038133175 7384.731951538235 5001.791682393892 0.9209744849619834 0.6896355761121924 0.6313824139769936 0.527695309280203 0.71436748331677 0.7818939485536145 1.3587726658297292 1.3635489982799494 1.476417336118215 1.0 12.288229257207822 -7.2081543556536625 4.135560628281577 1.3334360825989489 0.6895350991734245 0.790832348554521 0.14818947136465618 0.09287494334716082 3.3410637553080944 0.059582325378275146 0.04415819879357697 6.192209542910425e-08 7.2081543556536625 -0.6439009834255244 RPS(ph)PTSGDSRPAAGR ddPTM_A459_Selumetinib_30min_R1 1 RPSPTSGDSRPAAGR 15 2 Q8N1G1 Q8N1G1 REXO1 RNA exonuclease 1 homolog 1 RPS(0.985)PT(0.01)S(0.005)GDSRPAAGR 94.922 0.012607 4306500.0 228.52 290.38 235.17 368.44 361.65 281.96 213.66 245.36 263.6 409.04 True False 233.84407137748488 256.38217460600043 203.2352056963434 304.0988704753677 328.93882135449326 279.12373839919655 197.54345418134716 238.8522557583975 447.3099474177353 461.5442683870031 0.506655780158898 0.5554877227746764 0.4403374055680645 0.6588725964209828 0.7126918128656714 0.6047604910676788 0.4280054324403563 0.5175067097965147 0.9691593592549342 1.0 8.850325218403087 -8.266006431600422 23.935420911170766 0.9845798546467611 0.5557703029987041 0.8061060578604959 0.08464933176466727 101.10369552384189 529855.2416905152 0.07972000111337876 0.023383772793430322 5.419928638033393e-09 8.266006431600422 -0.428809551648057 RPS(ph)QEQSASASSGQPQAPLNR ddPTM_A459_Selumetinib_30min_R1 4 RPSQEQSASASSGQPQAPLNR 21 1 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 RPS(1)QEQSASASSGQPQAPLNR;RPS(1)QEQSASASSGQPQAPLNR;RPS(1)QEQSASASSGQPQAPLNR;RPS(0.997)QEQS(0.003)ASASSGQPQAPLNR 251.38 8.6568e-39 70879000.0 2580.72 3774.77 3632.35 4249.75 3615.88 2478.94 3385.99 3220.68 1884.47 2532.29 True False 2640.845754793026 3332.8181735570383 3139.096821070345 3507.6109401875315 3288.8242924354654 2454.004114297434 3130.582048223812 3135.257104156975 3197.8079537568274 2857.334088093398 0.9242341544160042 1.1664082920667198 1.0986103564686613 1.2275816660025365 1.1510114641966793 0.858843956862919 1.0956303854243181 1.0972665454913695 1.1191578776462279 1.0 11.480454015040946 RPS(ph)QEQSASASSGQPQAPLNR ddPTM_A459_Selumetinib_30min_R2 2 RPSQEQSASASSGQPQAPLNR 21 1 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 RPS(1)QEQSASASSGQPQAPLNR;RPS(1)QEQSASASSGQPQAPLNR 226.72 1.8152e-24 88551000.0 23167.5 22160.9 27278.1 26063.1 21455.5 15545.9 16963.2 23681.7 16729.6 19748.4 True False 21879.943096850628 23860.56977147548 25523.056744149668 22513.26081864474 18760.068275396352 17687.206613370476 17752.022411943122 23750.609826283508 20075.987464079764 19178.212379494722 1.140875002523415 1.2441498352050329 1.3308360674657473 1.173897773846526 0.978196919722015 0.9222552270972646 0.9256348850805054 1.2384162484130992 1.046812240203625 1.0 14.227180631113553 -6.107052545213372 4.473546235730914 1.021927411203544 1.2411404113074846 0.5383385529108748 0.09366068381213179 0.1935663066471636 6.350062727940122 0.030509980577325645 0.04043182322184743 7.815332412977367e-07 6.107052545213372 0.21921300010394074 RPS(ph)QGPPAR ddPTM_A459_Selumetinib_30min_R1 1 RPSQGPPAR 9 1 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 RPS(1)QGPPAR 79.036 0.025649 3692300.0 1531.3 1465.2 1910.9 1960.0 1369.5 1133.4 943.36 631.74 554.22 610.16 True False 1566.9763106088847 1293.6537028470007 1651.4102758223532 1617.7227937567066 1245.6289668048628 1121.9990250448623 872.2015956965067 614.9842030192781 940.470861372751 688.4799794617 2.275994011959581 1.8789997406438255 2.3986322407131384 2.34970201315302 1.8092450092430854 1.629675602073595 1.2668510657033958 0.893249217646262 1.366010471514472 1.0 9.427270892136018 -6.908568372360994 1.4098425285289233 1.0913855105516828 2.2089148250543307 0.8706665145071855 0.18787579637150986 0.13937451271056467 0.5714728972269485 0.09428499838400359 0.07501607854086322 1.2343309752237011e-07 6.908568372360994 1.117529314502648 up RPS(ph)QNAISFFNVGHSK ddPTM_A459_Selumetinib_30min_R1 1 RPSQNAISFFNVGHSK 16 1 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 RPS(0.939)QNAIS(0.061)FFNVGHSK 90.397 0.019653 0.0 3451.2 2897.7 3498.0 3515.8 3372.6 2879.3 2838.1 3365.3 1695.7 2150.0 True False 3531.606245133798 2558.4359368958176 3022.9908131386205 2901.8315297397094 3067.548925480891 2850.3368561952293 2624.0198320325812 3276.04131196501 2877.4790509721297 2425.9734427734625 1.4557481062514581 1.0546017906819785 1.2460939430905829 1.1961513999189655 1.2644610494886357 1.1749250036870227 1.081635843891475 1.3504027926289741 1.1861131701765413 1.0 11.244348041967692 -11.127701279194685 1.8599886345386512 0.9599677647940446 1.2176083011409355 0.2619116302506177 0.1121094337286386 215514.8805630926 125992.66864804913 41556.21410995006 0.02799477273047883 7.452443991647274e-12 11.127701279194685 0.257640536346891 RPS(ph)QNAISFFNVGHSK ddPTM_A459_Selumetinib_30min_R2 1 RPSQNAISFFNVGHSK 16 1 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 RPS(0.999)QNAIS(0.001)FFNVGHSK 105.06 0.0019164 4148300.0 37484.0 25962.0 31002.0 39131.0 37163.0 19552.0 19721.0 28044.0 24493.0 26133.0 True False 35400.78934034094 27953.2019190126 29007.365072425426 33801.29029525986 32494.25169856469 22245.11052461547 20638.06557642015 28125.60339706587 29392.284391599656 25378.472388311722 1.3949141145565989 1.1014532904623011 1.1429909818285604 1.3318882940656167 1.280386431514696 0.8765346544207543 0.8132114991257391 1.1082465077771726 1.1581581405639108 1.0 14.63131761089809 -6.751515371878606 24.999927111766155 0.9868693964295331 1.2406240313493906 0.5285503113576506 0.12214413408494537 183.32803607468577 461827.64822555805 0.043564583071174334 0.04306401694001669 1.7720853209614076e-07 6.751515371878606 0.2537546349198575 RPS(ph)RHDNSAIGR ddPTM_A459_Selumetinib_30min_R2 1 RPSRHDNSAIGR 12 2 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 RPS(1)RHDNSAIGR 60.301 0.037357 1399900.0 650.54 926.55 0.0 784.62 616.59 0.0 0.0 685.07 0.0 547.88 True False 614.3855911179538 997.61340567218 0.0 677.7534024550042 539.1284518154619 0.0 0.0 687.0634402805565 0.0 532.061280836805 1.1547271211911385 1.874997188487711 0.0 1.2738258295906448 1.013282625955307 0.0 0.0 1.291323885098292 0.0 1.0 9.055448609312887 -5.252981427434598 24.992428493309333 0.5826331871477386 1.514862171503302 0.32452601173855367 0.543772424145576 720.9257852695918 2130253.968012149 0.13690706460715552 0.34989402799586217 5.584940781763765e-06 5.252981427434598 0.9322289843555633 RPS(ph)SPVISK ddPTM_A459_Selumetinib_30min_R2 1 RPSSPVISK 9 1 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 RPS(0.5)S(0.5)PVISK 68.46300000000001 0.040676 18871000.0 91186.0 80981.0 92508.0 92061.0 99002.0 75517.0 75436.0 87906.0 55835.0 76042.0 True False 86118.24716647988 87191.9823050443 86556.13599509497 79522.1329859171 86564.48367089032 85918.7812749276 78943.92347359828 88161.79190637822 67003.56016024847 73846.46987915655 1.166179606248004 1.1807197073567164 1.1721093254252601 1.076857608983182 1.1722223663845506 1.1634785171928512 1.0690277220127553 1.1938524895048805 0.9073359941225909 1.0 16.172241336293588 -8.261486379887932 24.999999990512194 0.9536679823009293 1.1472585778645357 0.7488947280144113 0.045301395805822396 1.945785668568227 1033310.4103862416 0.03451653844316265 0.01110094699761525 5.476632762163428e-09 8.261486379887932 0.19359059556360636 RPS(ph)TADGEGDERPFTQAGLGADER ddPTM_A459_Selumetinib_30min_R2 1 RPSTADGEGDERPFTQAGLGADER 24 2 O60303 O60303 KIAA0556 Uncharacterized protein KIAA0556 1 RPS(0.5)T(0.5)ADGEGDERPFTQAGLGADER 49.089 0.01854 6310300.0 9373.1 7645.9 8263.7 8426.5 10346.0 7656.6 7090.9 7133.6 9061.2 7504.2 True False 8852.180625492198 8232.315944556596 7732.022538836265 7278.796163476707 9046.242985586474 8711.227150305376 7420.6409003517865 7154.357594968943 10873.693191081655 7287.534247746866 1.2147017529597317 1.1296435343822686 1.0609929608532302 0.9988009546201638 1.2413311111894068 1.195360029079614 1.0182649779856712 0.9817254165468796 1.492094969494455 1.0 12.831215042932472 -6.268056508163387 24.924976650678488 1.1490839877619226 1.100218151131703 0.02952889389917046 0.1488128002225495 2604.614417067696 9810883.718475755 0.0457184150105583 0.05307493007934401 5.394404287356235e-07 6.268056508163387 -0.048865836630219484 RPS(ph)TASLTR ddPTM_A459_Selumetinib_30min_R1 2 RPSTASLTR 9 1 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 RPS(0.875)T(0.118)AS(0.007)LTR;RPS(0.859)T(0.126)AS(0.013)LT(0.002)R 75.08800000000002 0.030786 15835200.0 1852.38 2467.8999999999996 2364.0 2238.8199999999997 1913.8600000000001 2435.3 2765.6 2579.9 1159.26 1615.65 True False 1895.5368498959617 2178.9571207044164 2042.9817845224966 1847.85211485632 1740.751700919428 2410.8030930754844 2556.9885654026652 2511.4726713037553 1967.1795509995588 1823.0344152636942 1.0397701952443834 1.195236415978049 1.1206490494185146 1.0136134015819092 0.9548649692757641 1.3224122775141203 1.4026002712805659 1.3776331649452056 1.079068795700719 1.0 10.832126081509022 -6.773386745433448 24.941930408437692 1.2703360826364594 1.0723278225229698 0.2758839642318328 0.13309005293628254 256.18510799145315 534821.8763598875 0.047079232808914045 0.04183988721510296 1.6850517943858135e-07 6.773386745433448 -0.1980082601134896 RPS(ph)TSQTVSTPAPVPVIESTEAIEAK ddPTM_A459_Selumetinib_30min_R2 1 RPSTSQTVSTPAPVPVIESTEAIEAK 26 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 RPS(0.189)T(0.189)S(0.189)QT(0.145)VS(0.145)T(0.145)PAPVPVIESTEAIEAK 64.845 0.00089063 2566100.0 18789.0 22110.0 21133.0 20951.0 23535.0 16773.0 19141.0 15801.0 15707.0 23033.0 True False 17744.782598326383 23805.765905144774 19773.325787870657 18097.437657509116 20578.322894430476 19083.32849986576 20031.094427171953 15846.97829400364 18848.838890248466 22367.977443079024 0.7933118961462864 1.0642788766094102 0.8840015078783446 0.8090779644052585 0.9199903275473709 0.8531539585296933 0.8955255108847521 0.7084671975519595 0.8426706857253456 1.0 14.449147190494605 -5.512857545719071 24.602134936435736 0.852187431274136 0.9401315858315727 0.06700222615577278 0.0937539240701853 741.8088246351859 1821142.6156305673 0.023938445083755255 0.04494315122909339 3.070028832938968e-06 5.512857545719071 0.08794415455743676 RPS(ph)VGSQSNQAGQGK ddPTM_A459_Selumetinib_30min_R1 4 RPSVGSQSNQAGQGK 15 1 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;H0Y3N9 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 RPS(1)VGSQSNQAGQGK;RPS(0.999)VGS(0.001)QSNQAGQGK;RPS(0.995)VGS(0.005)QSNQAGQGK;RPS(0.953)VGS(0.045)QS(0.001)NQAGQGK 147.75 0.0005708999999999999 5455500.0 2498.15 4119.05 3711.09 4289.0 3640.6800000000003 3729.09 3907.6000000000004 3669.0899999999997 2107.0 2707.37 True False 2556.3520344462795 3636.789711105609 3207.144361558205 3540.0066645012816 3311.381136814261 3691.5787403428135 3612.8465859731937 3571.7738143160195 3575.4251108086787 3054.8873115170154 0.8368073103085527 1.190482443458652 1.0498404800292227 1.1588010631866361 1.083961796014621 1.2084173208044213 1.1826447975192589 1.1691998591405734 1.1703950902965292 1.0 11.57690344764748 -4.755659931689922 24.99763420297998 1.1404404396850936 0.8368068209231495 0.6543277173088493 0.06487641698369108 109.25821941827733 472522.84118882735 0.015330864703971778 0.13357300722371335 1.7552543916352205e-05 4.755659931689922 -0.30363361876194406 RPS(ph)VGSQSNQAGQGK ddPTM_A459_Selumetinib_30min_R2 1 RPSVGSQSNQAGQGK 15 1 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;H0Y3N9 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 RPS(0.993)VGS(0.007)QSNQAGQGK 87.363 0.0096179 7442100.0 26942.0 24710.0 28906.0 31899.0 29201.0 23221.0 27799.0 29157.0 21721.0 33686.0 True False 25444.67149737129 26605.1775448271 27046.219430473157 27554.301171155712 25532.509319747798 26419.48197074956 29091.708582673495 29241.8420427988 26065.806935448334 32713.397653260963 0.7778058325542011 0.8132807795394197 0.8267627752135099 0.8422940797287994 0.780490904380354 0.8076043415232349 0.8892903418662033 0.8938796988543283 0.7967930207594937 1.0 14.997593986813282 -14.522878745041954 0.16281579067575883 1.654508992454687 0.782783277051869 0.6954636912728134 0.0357949945781235 76.85779616889684 0.7096671657716725 16.206984687689303 0.1491639118788321 3.000000001646696e-15 14.522878745041954 -0.871725715402818 RPS(ph)VNGEPGSVPPPR ddPTM_A459_Selumetinib_30min_R1 1 RPSVNGEPGSVPPPR 15 1 Q8N3D4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 RPS(1)VNGEPGSVPPPR 163.44 0.00018529 11877000.0 901.27 715.88 699.66 891.28 875.79 824.6 1152.9 849.38 440.03 712.02 True False 922.2678374338599 632.0644367964171 604.6500149572801 735.6346793976925 796.5749491332831 816.3052726768954 1065.935824794885 826.8516832249253 746.6987714803721 803.4147026621205 1.1479349760191326 0.786722516655554 0.7526001365842171 0.9156350723482675 0.9914866463033676 1.0160447275511164 1.3267566815281062 1.0291717098095743 0.9294064061887096 1.0 9.650001053029701 -6.503983806817884 2.22267740623016 1.079042418652156 0.8817162634870107 0.22146962164240214 0.13882377233029275 0.42447277320910254 4.198569252330707 0.05156716478372887 0.05621704901022353 3.13340255474837e-07 6.503983806817884 -0.1973261551651454 RPS(ph)VNGEPGSVPPPR ddPTM_A459_Selumetinib_30min_R2 1 RPSVNGEPGSVPPPR 15 1 Q8N3D4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 RPS(1)VNGEPGSVPPPR 115.66 0.0042164 5059000.0 8186.4 8068.4 9442.6 9435.7 9470.9 6638.5 5941.7 6652.4 7667.9 10334.0 True False 7731.432660755706 8687.220336004986 8835.073396325537 8150.5413825096075 8281.080871079737 7552.893116696998 6218.000823255189 6671.757382635894 9201.694259026945 10035.630569043487 0.7703982931181774 0.8656377171557222 0.880370529339605 0.812160364656234 0.8251679666870221 0.7526077275099293 0.6195924392071197 0.6648069931167055 0.916902450296551 1.0 13.292843647993994 -6.712869497704074 5.393999488110262 0.759085248406168 0.8352900105669548 0.0 0.10912306591727698 0.4892386395240211 31.479059612558185 0.03649222046800102 0.03577522496986874 1.9370039319312022e-07 6.712869497704074 0.07620476216078687 RPS(ph)VYLPTR ddPTM_A459_Selumetinib_30min_R2 1 RPSVYLPTR 9 1 Q9BW61 Q9BW61 DDA1 DET1- and DDB1-associated protein 1 1 RPS(1)VYLPTR 70.563 0.037472000000000005 3275200.0 5787.2 5495.4 6580.3 8393.1 7195.0 3829.9 6325.1 5322.4 4868.9 6707.1 True False 5465.570591997151 5916.879509503961 6156.930662088925 7249.945301094924 6291.099775883886 4357.433960629332 6619.229682947879 5337.887302829246 5842.816048432596 6513.448595861383 0.8391208607173088 0.9084096423611174 0.9452643360079653 1.113073235229262 0.9658631189445823 0.668990304674858 1.016240411746507 0.8195178367141666 0.8970387901955803 1.0 12.669205876411912 -6.6203252358263756 21.27261869049243 0.8708894704732546 0.9601790749915587 0.09607693815885077 0.11084139435722415 10.420638705060677 2256.80355691166 0.036415042351755314 0.03641501677613549 2.3970371459255877e-07 6.6203252358263756 0.08928960451830414 RPSASS(ph)PNNNTAAK ddPTM_A459_Selumetinib_30min_R1 3 RPSASSPNNNTAAK 14 1 O75151;E7ET14;A0A087WW48 O75151 PHF2 Lysine-specific demethylase PHF2 1 RPS(0.004)AS(0.054)S(0.942)PNNNTAAK;RPS(0.01)AS(0.058)S(0.932)PNNNTAAK;RPSAS(0.032)S(0.968)PNNNTAAK 143.83 0.00027454 26483900.0 4347.92 6881.3 5598.1 7281.799999999999 5602.8 4902.35 5188.599999999999 3981.8199999999997 2513.51 4305.150000000001 True False 4449.218076420416 6075.63419697042 4837.908768162182 6010.17032631509 5096.027729254682 4853.036809977662 4797.219724634173 3876.2091988258157 4265.24289049299 4857.757938212174 0.9158995019949234 1.2507074815684347 0.9959139236037569 1.237231332388506 1.049049333884718 0.9990281260831516 0.9875378282845684 0.797942023486744 0.8780270537857944 1.0 12.246074887019237 -7.131532013171325 1.5796028032068445 0.8856082896839137 1.1028487407180059 0.3742194958578705 0.10708603687205002 0.3599350453683848 1.7788848890486282 0.05336203885475144 0.035830474475940545 7.386998091699212e-08 7.131532013171325 0.21724045103409217 RPSASS(ph)PNNNTAAK ddPTM_A459_Selumetinib_30min_R2 2 RPSASSPNNNTAAK 14 1 O75151;E7ET14;A0A087WW48 O75151 PHF2 Lysine-specific demethylase PHF2 1 RPS(0.004)AS(0.161)S(0.835)PNNNTAAK;RPS(0.058)AS(0.058)S(0.884)PNNNTAAK 96.805 0.005924100000000001 7115900.0 31188.0 32146.0 34095.0 32285.0 36679.0 28432.0 26042.0 28445.0 21926.0 27661.0 True False 29454.695815455998 34611.49483431859 31901.36481982919 27887.72730526857 32071.056105579595 32348.249920001363 27253.004601244033 28527.770240676764 26311.812663626904 26862.355058090943 1.0965045972983014 1.2884758152987634 1.187586298775412 1.0381713459210935 1.1939033653685474 1.2042224090198699 1.0145426394040393 1.0619981077230307 0.9795050585373669 1.0 14.71329817283629 -7.26855233877343 24.510695913990915 1.0191779459725538 1.1697603789897997 0.5714857324058809 0.06531500912717512 340.6655225340568 1173899.705681908 0.027657935694557777 0.019097865618838604 5.38824905257262e-08 7.26855233877343 0.15058243301724583 RPSS(ph)MYSTGGK ddPTM_A459_Selumetinib_30min_R2 1 RPSSMYSTGGK 11 1 O75382-3;O75382-2;O75382;A0A1W2PPI7;O75382-4 O75382-3 TRIM3 Tripartite motif-containing protein 3 1 RPS(0.201)S(0.798)MYSTGGK 106.17 0.020241 10189000.0 23285.0 26702.0 24143.0 28553.0 25492.0 25439.0 22813.0 22149.0 21837.0 22864.0 True False 21990.912917240392 28749.957539537583 22589.665664910866 24664.03214332766 22289.46705862851 28942.991337750253 23873.849703101918 22213.449923035667 26205.01017675915 22203.856912193743 0.990409594342305 1.2948181774558682 1.0173757538720782 1.1107994543859114 1.0038556430431576 1.30351188319249 1.0752118335797354 1.000432042544674 1.180200821883701 1.0 14.43852268066495 -13.887146219723103 0.4027431169717996 3.1728896496663355e-05 1.11197449397284 0.07585840743303818 0.11147785589647413 1201.267439719688 14.086910441653426 1038.5564471547996 0.06617418588517879 1.2967426058283983e-14 13.887146219723103 1.1119427650763434 RPSS(ph)PVISK ddPTM_A459_Selumetinib_30min_R2 2 RPSSPVISK 9 1 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 RPS(0.19)S(0.81)PVISK;RPS(0.023)S(0.977)PVISK 78.28699999999998 0.026623 163934000.0 159017.0 139178.0 175128.0 188917.0 171467.0 134855.0 137022.0 124502.0 101369.0 148694.0 True False 150179.4717354869 149852.5050721953 163860.45514494932 163186.17869999734 149925.7825255707 153430.05215819456 143393.79450394225 124864.28020758447 121645.6324865088 144400.81786659136 1.0400181519348064 1.0377538526869052 1.1347612677397456 1.1300917897207574 1.0382613114011843 1.0625289691914703 0.99302619349719 0.8647061841640242 0.8424165062478693 1.0 17.139719387913516 -7.500946510992117 2.5955147762926023 0.8904116791844312 1.0766936145122596 0.6885712420735535 0.05133212273201699 0.15487205494520592 2.0809508005147292 0.027761376952187566 0.015466804609172737 3.155393227114725e-08 7.500946510992117 0.18628193532782844 RPSTSQT(ph)VSTPAPVPVIESTEAIEAK ddPTM_A459_Selumetinib_30min_R1 1 RPSTSQTVSTPAPVPVIESTEAIEAK 26 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 RPS(0.145)T(0.145)S(0.145)QT(0.524)VS(0.021)T(0.021)PAPVPVIESTEAIEAK 90.869 4.7376e-05 4278700.0 506.22 638.72 755.74 668.55 771.9 594.63 737.98 660.57 391.78 569.56 True False 518.0139410673481 563.9383654671282 653.1146589826702 551.8002927377786 702.0817812900133 588.648562080842 682.3135744488932 643.0495377662396 664.8220455209421 642.6685739842103 0.8060358978749056 0.8774948523949198 1.0162542333970053 0.8586078658193979 1.0924476623113404 0.9159442143429041 1.0616880956523276 1.0005927842086124 1.0344710670997834 1.0 9.327931117158409 -3.381804933762887 0.5161000231321058 1.0168216122816842 1.2969034401232234e-12 0.5164969981033025 0.06303157705743342 12.658800290954481 0.833567335755873 0.032165232256693196 10.669589300718412 0.0004151404638483697 3.381804933762887 -1.0168216122803873 RPSTSQT(ph)VSTPAPVPVIESTEAIEAK ddPTM_A459_Selumetinib_30min_R2 1 RPSTSQTVSTPAPVPVIESTEAIEAK 26 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 RPS(0.126)T(0.126)S(0.126)QT(0.37)VS(0.126)T(0.126)PAPVPVIESTEAIEAK 77.169 0.00022002 1838500.0 14739.0 14665.0 16471.0 16610.0 17460.0 16078.0 14198.0 14855.0 13105.0 18930.0 True False 13919.86538489183 15789.758344592852 15411.273792268858 14347.6893461518 15266.518705619554 18292.598558447593 14858.235132803266 14898.225590622362 15726.366184294031 18383.44171395327 0.7571958288053575 0.8589119812427845 0.8383236410280834 0.7804680739005317 0.8304494306978474 0.9950584250262166 0.8082401197772272 0.8104154718381388 0.8554636519644477 1.0 14.1661192701602 -6.541539656357879 24.999847568625643 0.880649800205291 0.8133031936308703 0.25871571091647405 0.0671390602850788 422.40831586862515 565892.5612936334 0.022211473916382195 0.022214978268501422 2.873825166512198e-07 6.541539656357879 -0.06734660657442071 RPSTSQTVST(ph)PAPVPVIESTEAIEAK ddPTM_A459_Selumetinib_30min_R1 2 RPSTSQTVSTPAPVPVIESTEAIEAK 26 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 RPS(0.004)T(0.004)S(0.004)QT(0.004)VS(0.216)T(0.768)PAPVPVIESTEAIEAK;RPSTSQTVS(0.017)T(0.982)PAPVPVIESTEAIEAK 117.23 9.696799999999998e-09 22715000.0 3148.4 3908.0 3101.3 3436.2 3659.2000000000003 3312.5 3889.3 3323.3 2057.21 3262.2 True False 3221.751594280033 3450.4495432200883 2680.160494221498 2836.1321754626506 3328.2260060842304 3279.179257509357 3595.926969706607 3235.1552884002363 3490.935117326401 3680.9351465188784 0.8752535608585489 0.9373839543147713 0.7281194553933313 0.770492296813441 0.9041794744011693 0.8908549395689656 0.9769058205514256 0.8788949437100995 0.9483826740679842 1.0 11.845856616122765 -6.575767320689425 2.6847347700340434 0.9352907078984044 0.8294031226841742 0.404699848234802 0.06283591918601673 0.31954121860684653 4.676850196787217 0.023472212793213716 0.02426715477378086 2.656028184897163e-07 6.575767320689425 -0.10588758521423025 RPSTSQTVST(ph)PAPVPVIESTEAIEAK ddPTM_A459_Selumetinib_30min_R2 1 RPSTSQTVSTPAPVPVIESTEAIEAK 26 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 RPS(0.031)T(0.031)S(0.031)QT(0.022)VS(0.065)T(0.82)PAPVPVIESTEAIEAK 81.726 0.00015939 8628100.0 17160.0 15561.0 15318.0 18698.0 18116.0 16227.0 16674.0 16789.0 13905.0 19896.0 True False 16206.315896922708 16754.47866349877 14332.456556977375 16151.300144150891 15840.10612090514 18462.121955960265 17449.374038904203 16837.853210431425 16686.38853816164 19321.55078398385 0.8387688999765255 0.8671394367261144 0.7417860355628354 0.8359215222796266 0.8198154639862255 0.9555196765708895 0.9031042194277933 0.8714545430995514 0.863615385986172 1.0 14.23792327178604 -6.741850482767715 24.93801061701508 0.9097275081923573 0.8197300241828044 0.5085731170471017 0.04777931822898684 216.27415380730247 275331.2470767715 0.015781864000009138 0.01576037723149032 1.8119638011712306e-07 6.741850482767715 -0.08999748400955287 RPSVNGEPGS(ph)VPPPR ddPTM_A459_Selumetinib_30min_R2 1 RPSVNGEPGSVPPPR 15 1 Q8N3D4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 RPS(0.381)VNGEPGS(0.619)VPPPR 91.469 0.026043 4870900.0 4630.9 2619.8 4353.0 3404.3 3522.6 3020.2 4008.2 4326.0 3284.0 4122.8 True False 4373.533116961502 2820.7302360152994 4072.932719188046 2940.6284672549405 3080.0594955564397 3436.205135354111 4194.589242097625 4338.587943792146 3940.8917626265993 4003.764051679161 1.0923553587348038 0.7045195969608392 1.0172759100226887 0.7344659748422622 0.7692909611555846 0.8582436654610007 1.04766144756668 1.0836272786785628 0.984296704740582 1.0 11.967141240978254 -7.257590967150013 21.68732172634651 1.0358653253193704 0.8524548096045758 0.32849758448124533 0.1156893238096997 56.19142398048121 316666.195208694 0.0433666078116064 0.032186095983753604 5.525976489369591e-08 7.257590967150013 -0.1834105157147946 RPSYLEWTAQVQS(ph)QAWRRAQAK ddPTM_A459_Selumetinib_30min_R1 1 RPSYLEWTAQVQSQAWRRAQAK 22 3 Q9BTA0 Q9BTA0 FAM167B Protein FAM167B 1 RPSYLEWTAQVQS(1)QAWRRAQAK 64.705 0.030608 18683000.0 2990.2 3985.2 3710.5 4130.3 3148.8 3260.2 2997.1 2706.7 2033.3 2459.3 True False 3059.865842083648 3518.610931330784 3206.6344803175675 3409.0206403333286 2863.9915959657937 3227.4053480247585 2771.0263340209476 2634.90952339931 3450.3615936437072 2774.9751106105946 1.1026642474679231 1.267979275877744 1.1555543212104675 1.2284869249091106 1.0320783004556795 1.1630393857170895 0.9985770046821147 0.9495254618047853 1.2433846993620434 1.0 11.438259116319534 -6.262805487174115 24.99931308842796 1.0635478183716796 1.191970566745582 0.3137893283601523 0.08994630114330789 148.7085480113594 2721317.5565503924 0.026436380615095793 0.03166564477694712 5.460023511428027e-07 6.262805487174115 0.12842274837390244 RPTETNPVTS(ph)NSDEECNETVK ddPTM_A459_Selumetinib_30min_R2 1 RPTETNPVTSNSDEECNETVK 21 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RPTETNPVT(0.132)S(0.851)NS(0.017)DEECNETVK 75.358 0.001561 18659000.0 19052.0 18050.0 22034.0 23322.0 22177.0 15298.0 19097.0 20165.0 13554.0 18562.0 True False 17993.1661111988 19434.376960102363 20616.3564288053 20145.50336730598 19390.926995104503 17405.160638582624 19985.0483399876 20223.67681150453 16265.178730402224 18026.066830132106 0.9981748254212445 1.0781263124807763 1.1436968820254956 1.1175762054554828 1.0757159161692953 0.9655550932213574 1.108674927720832 1.1219128943702201 0.9023143475321855 1.0 14.137797024036121 -6.543539655797913 24.892515791689576 1.0315127999545068 1.0892398934100165 0.15957128942874454 0.06953183102588434 485.9124657487339 585428.9418053504 0.023286876167881127 0.02328914639697371 2.8606211429557967e-07 6.543539655797913 0.05772709345550964 RPTETNPVTS(ph)NSDEECNETVKEK ddPTM_A459_Selumetinib_30min_R2 1 RPTETNPVTSNSDEECNETVKEK 23 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RPT(0.004)ET(0.003)NPVT(0.095)S(0.83)NS(0.068)DEECNETVKEK 57.24800000000001 0.018369 9981800.0 14940.0 15009.0 12583.0 15318.0 11293.0 8864.0 10516.0 10761.0 6430.4 16109.0 True False 14109.694609558574 16160.14203845853 11773.423479334528 13231.661974976118 9874.272379299064 10084.93554061945 11005.014837058687 10792.31272842055 7716.659680387969 15643.891313791502 0.9019299819041573 1.0330001477453314 0.7525891891715709 0.8458037523765722 0.6311902953834767 0.6446564565255365 0.7034704228197222 0.6898739266301442 0.4932698345701902 1.0 13.933311797618735 -5.625793253777727 1.341502734634497 0.6799185176689726 0.9719651561783613 0.3446502272646037 0.1325088937079403 0.4756063610548142 1.6379337814377388 0.04124575997204333 0.12353787966083088 2.3670462635082136e-06 5.625793253777727 0.2920466385093887 RPTETNPVTSNS(ph)DEECNETVK ddPTM_A459_Selumetinib_30min_R1 4 RPTETNPVTSNSDEECNETVK 21 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RPTETNPVTSNS(1)DEECNETVK;RPTETNPVT(0.003)S(0.006)NS(0.991)DEECNETVK;RPTETNPVTSNS(1)DEECNETVK;RPTETNPVTSNS(1)DEECNETVK 194.43 7.3346e-17 253636000.0 16384.0 23460.300000000003 17391.5 19465.2 17801.2 17453.699999999997 20459.9 18139.3 9438.3 16905.199999999997 True False 16765.71532228563 20713.557169602427 15029.829824671324 16065.96822705767 16191.084603057114 17278.131624691643 18916.593270640016 17658.186839249676 16016.105753842228 19075.147090592523 0.8789298055035256 1.085892395546346 0.7879273356735337 0.8422460991129699 0.8488052294517944 0.9057928383269384 0.9916879372306019 0.9257169423326931 0.8396320970830703 1.0 14.219406561434955 -7.01126936732338 24.34311679009876 0.9353077613768924 0.8901033236934851 0.07483332316659841 0.08336882735600401 1318.6959061712228 2848535.6925987788 0.03184749352204513 0.02623887432968708 9.743850964907938e-08 7.01126936732338 -0.04520443768340732 RPTETNPVTSNS(ph)DEECNETVK ddPTM_A459_Selumetinib_30min_R2 4 RPTETNPVTSNSDEECNETVK 21 1 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RPTETNPVT(0.001)S(0.015)NS(0.985)DEECNETVK;RPTETNPVTS(0.001)NS(0.999)DEECNETVK;RPTETNPVTS(0.003)NS(0.997)DEECNETVK;RPTETNPVT(0.002)S(0.024)NS(0.973)DEECNETVK 184.0 4.1468e-15 336268400.0 184206.0 159110.0 191694.0 185738.0 173998.0 146969.0 153519.0 176507.0 142939.0 169241.0 True False 173968.56795504314 171313.22538071414 179360.61674064642 160440.16398407827 152138.81567814373 167212.6456982514 160657.9376921273 177020.60614769312 171530.7940493557 164354.5725890736 1.058495454154518 1.0423392710164436 1.0913028698574245 0.9761831475490353 0.9256743714610713 1.017389678085341 0.9775081712743778 1.0770652946193817 1.0436630471987196 1.0 17.326452069338835 -5.763489987839971 24.993391602981845 1.0020870264686368 1.061875206202172 0.3321867227068276 0.039952381677880566 70.3675490140481 857677.4293958048 0.012226650121600114 0.019205675237865292 1.7238918329133352e-06 5.763489987839971 0.05978817973353512 RPTETNPVTSNS(ph)DEECNETVKEK ddPTM_A459_Selumetinib_30min_R1 2 RPTETNPVTSNSDEECNETVKEK 23 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RPTETNPVT(0.014)S(0.342)NS(0.644)DEECNET(0.001)VKEK;RPTETNPVT(0.004)S(0.092)NS(0.904)DEECNETVKEK 104.82 2.5001e-05 51939000.0 1408.31 1398.8400000000001 3489.2 3353.0 2437.51 2083.29 1649.61 1809.75 1216.24 1245.14 True False 1441.120882905766 1235.0631624969267 3015.385804803681 2767.4614936052208 2217.0376508773443 2062.3339940759747 1525.178589591369 1761.7495511035197 2063.870449345016 1404.9658476906743 1.0257337466775576 0.8790698823939281 2.1462342374798893 1.9697713635915524 1.5780010984049633 1.4678890575637897 1.0855627502250584 1.253944751752711 1.4689826466154856 1.0 10.456319346093238 -7.100063172674225 5.349784418346761 1.2249612911711663 1.5422686886675239 0.14030249318079346 0.372342216205811 0.5358406147269804 22.981366150915413 0.15970871390909147 0.12365007174594807 7.942126997785792e-08 7.100063172674225 0.3173073974963576 RPTETNPVTSNS(ph)DEECNETVKEK ddPTM_A459_Selumetinib_30min_R2 2 RPTETNPVTSNSDEECNETVKEK 23 2 P46100-4;P46100;P46100-5;P46100-3;P46100-2;P46100-6;A0A096LNL9;A0A096LNW1 P46100-4 ATRX Transcriptional regulator ATRX 1 RPTETNPVT(0.001)S(0.003)NS(0.985)DEECNET(0.012)VKEK;RPTETNPVT(0.002)S(0.104)NS(0.894)DEECNETVKEK 78.418 0.00079727 14210200.0 24920.7 35175.2 26879.6 30313.5 26715.8 15394.3 11439.7 14075.5 6326.200000000001 32144.0 True False 23535.70725946629 37873.0247339054 25150.19580029567 26184.749006295762 23359.522361717674 17514.725089458247 11971.668717335513 14116.457374675538 7591.61676879671 31215.919199858094 0.753964895564353 1.2132599553268182 0.8056849340002777 0.8388267806131046 0.748320823492645 0.5610831120275922 0.3835116512407533 0.45221982041585085 0.24319696370918403 1.0 14.929994328302424 -6.498269502064856 1.3544427868672875 0.4708001727914408 0.9475893538375476 0.3943934539008419 0.21715355777410714 0.3670821343858562 1.387827146374462 0.08710201884181959 0.09931814874459305 3.17490326843516e-07 6.498269502064856 0.4767891810461068 RPTPNDDTLDEGVGLVHSNIAT(ph)EHIPSPAK ddPTM_A459_Selumetinib_30min_R1 2 RPTPNDDTLDEGVGLVHSNIATEHIPSPAK 30 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 RPTPNDDTLDEGVGLVHSNIAT(0.598)EHIPS(0.402)PAK;RPTPNDDTLDEGVGLVHS(0.011)NIAT(0.808)EHIPS(0.182)PAK 145.63 1.0196e-19 61368600.0 12484.2 13231.7 15085.0 15611.9 11958.9 11568.9 10937.4 10724.4 6539.889999999999 9952.0 True False 12775.057569975475 11682.52641274956 13036.53985597372 12885.574736658324 10877.219606515286 11452.52736972076 10112.383112248737 10439.954074239313 11097.71567533298 11229.43614068907 1.137640163755503 1.0403484437138166 1.1609255970330281 1.1474819016039774 0.9686345307314629 1.0198666456834227 0.9005245664657401 0.9296953064643091 0.9882700730734992 1.0 13.454997867621472 -6.2695131278721945 23.949473891715705 0.9635529791336577 1.1186044552454157 0.7450662011199222 0.04400754862202794 175.6934768289465 521165.4343576107 0.014031895729828069 0.01620394597962174 5.376341812475732e-07 6.2695131278721945 0.15505147611175807 RPTPNDDTLDEGVGLVHSNIAT(ph)EHIPSPAK ddPTM_A459_Selumetinib_30min_R2 1 RPTPNDDTLDEGVGLVHSNIATEHIPSPAK 30 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 RPTPNDDTLDEGVGLVHS(0.021)NIAT(0.548)EHIPS(0.431)PAK 71.506 5.7254e-05 73381000.0 85030.0 89927.0 90466.0 95633.0 92296.0 103680.0 92433.0 95235.0 69237.0 115780.0 True False 80304.37300205934 96824.11173912071 84645.51605193337 82607.62042387313 80700.95134329108 117960.97888666781 96731.31765251479 95512.11808299697 83086.33464341579 112437.13056743317 0.7142157808260458 0.8611400099814118 0.7528252955652224 0.7347005389321096 0.7177428927260946 1.049128328794568 0.8603147124472466 0.8494713232272895 0.7389581557631933 1.0 16.778759015685374 -6.703296895180099 24.999999687398486 0.8877173998199628 0.7605853851669684 0.3941816866619894 0.08822204185345942 94.99279444083048 40844.22761484506 0.02935187839728182 0.029351864763674525 1.9801728645094377e-07 6.703296895180099 -0.1271320146529944 RPTPNDDTLDEGVGLVHSNIATEHIPS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 5 RPTPNDDTLDEGVGLVHSNIATEHIPSPAK 30 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 RPTPNDDTLDEGVGLVHS(0.019)NIAT(0.338)EHIPS(0.643)PAK;RPTPNDDTLDEGVGLVHSNIAT(0.006)EHIPS(0.994)PAK;RPTPNDDTLDEGVGLVHSNIAT(0.098)EHIPS(0.901)PAK;RPTPNDDTLDEGVGLVHSNIAT(0.009)EHIPS(0.991)PAK;RPTPNDDTLDEGVGLVHS(0.068)NIAT(0.231)EHIPS(0.7)PAK 141.9 1.4998e-18 332032000.0 22395.899999999998 25303.199999999997 27935.800000000003 29307.300000000003 20684.7 22493.8 21038.8 19916.100000000002 13330.5 18218.5 True False 22917.68089516459 22340.689580861446 24142.271800365317 24189.330221156077 18813.772537180397 22267.5327947363 19451.82637756494 19387.860331389886 22620.884878801666 20557.021938217826 1.1148346761530683 1.0867668307211162 1.1744051192299458 1.176694284505548 0.9151993218533016 1.0832081058073126 0.9462375647613528 0.9431259250322471 1.1003969809822933 1.0 14.327343658373152 -6.250690008133174 24.99760638595693 0.9968537632975727 1.1370910525840854 0.5649317688912878 0.0602436186862813 542.2937594184715 1261100.8095882006 0.017563024724821054 0.02244099533070132 5.61448585301388e-07 6.250690008133174 0.1402372892865127 RPTPNDDTLDEGVGLVHSNIATEHIPS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 4 RPTPNDDTLDEGVGLVHSNIATEHIPSPAK 30 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 RPTPNDDTLDEGVGLVHS(0.009)NIAT(0.226)EHIPS(0.765)PAK;RPTPNDDTLDEGVGLVHSNIAT(0.013)EHIPS(0.987)PAK;RPTPNDDTLDEGVGLVHSNIAT(0.002)EHIPS(0.998)PAK;RPTPNDDTLDEGVGLVHS(0.029)NIAT(0.029)EHIPS(0.941)PAK 121.84 3.5448e-16 94925700.0 267343.0 295367.0 301661.1 313693.0 329120.0 288443.5 292132.9 278034.0 250821.8 348828.0 True False 252485.1463188232 318020.6991454048 282252.5532497715 270967.4722493915 287773.00322986883 328173.97389560734 305717.65870035975 278843.0329089937 300993.1685466426 338756.42927601165 0.7453294594539004 0.9387886742845792 0.8332020556864413 0.7998887957005028 0.8494982777002806 0.9687608722201345 0.9024704250004578 0.8231372420146696 0.8885238552960412 1.0 18.36988880214789 -6.547865653674315 24.37797637699614 0.9051413745555459 0.8358127840231836 0.29532978596807014 0.06335784704044274 269.6798586527066 263105.2573488501 0.02077968468166828 0.020780614012062246 2.8322680049782537e-07 6.547865653674315 -0.06932859053236229 RPTPNDDTLDEGVGLVHSNIATEHIPS(ph)PAKK ddPTM_A459_Selumetinib_30min_R1 1 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK 31 2 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 RPTPNDDTLDEGVGLVHS(0.003)NIAT(0.051)EHIPS(0.947)PAKK 89.272 3.2122e-07 54026000.0 5737.0 6029.3 6868.2 6321.7 4958.9 5338.5 4949.7 4974.7 2883.5 4516.1 True False 5870.6609377412515 5323.386753054478 5935.53616432209 5217.733768006004 4510.368370564903 5284.799536970175 4576.340143973669 4842.75479589705 4893.088897492562 5095.785425539175 1.1520620370548842 1.0446646215467796 1.1647931905794606 1.0239312161488678 0.885117404661455 1.0370922430296408 0.8980637451957576 0.9503451168932703 0.9602227112957438 1.0 12.315088814213116 -5.979983918041143 5.742549152879251 0.9536780863993441 1.111440526701841 0.6774690501565355 0.05095702909097262 0.0929292577496034 9.939855709358854 0.013615226896578805 0.019835813320999846 1.0471673240214079e-06 5.979983918041143 0.15776244030249686 RPTPQDS(ph)PIFLPVDDTSFR ddPTM_A459_Selumetinib_30min_R2 1 RPTPQDSPIFLPVDDTSFR 19 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 RPT(0.003)PQDS(0.997)PIFLPVDDTSFR 76.237 0.0045254 2734200.0 12362.0 10612.0 13196.0 13564.0 9554.6 7626.9 11876.0 8277.9 9764.4 10633.0 True False 11674.969529006894 11425.9062770419 12346.983726718467 11716.559800794877 8354.265728792247 8677.436244895127 12428.257531847565 8301.987318519885 11717.55284013129 10325.997662148187 1.130638405217116 1.1065183869763624 1.1957182376651672 1.1346661295250964 0.8090516773421632 0.8403484611180806 1.2035890321189584 0.8039888822512832 1.1347622983766594 1.0 13.33399355612882 -6.131706190821749 9.719599094623007 0.9612558276625245 1.1445249837993396 0.32255518820814655 0.12534592461948235 0.4341882146452521 31.9563317192485 0.036124241528779695 0.046683630521054446 7.384036064668702e-07 6.131706190821749 0.18326915613681516 RPTWAEER ddPTM_A459_Selumetinib_30min_R1 2 RPTWAEER 8 1 Q8ND56-3;Q8ND56-2;Q8ND56;A0A0G2JQ95;A0A096LP11;A0A140TA76 Q8ND56-3;A0A140TA76 LSM14A Protein LSM14 homolog A 0 ; 106.2 0.018711 8138300.0 2866.2 3407.6000000000004 3288.5 3549.4 3038.3 3338.6 3080.8999999999996 2936.2 1545.6799999999998 2814.2 False True 2932.9768833456474 3008.6366078497404 2841.9397624374938 2929.5639204898234 2763.4863014554344 3305.016715206262 2848.5052325531788 2858.3224378782484 2622.906067999412 3175.4299826293386 0.9236471594051859 0.9474737671143708 0.8949779330622475 0.9225723560322587 0.8702715275010396 1.0408091922309124 0.8970455176575937 0.900137132140915 0.8260002841654778 1.0 11.632736244044732 -11.002985402775064 3.009983269330945 1.0022756602338234 0.9159438834637075 0.19269887738116798 0.05283099900972331 64680805.946534194 73251990.70582294 1226664.8868708473 0.013365219480690875 9.93149428955527e-12 11.002985402775064 -0.08633177677011594 RPVS(ph)AIFTESIQPQKPGPGAAATVGK ddPTM_A459_Selumetinib_30min_R1 2 RPVSAIFTESIQPQKPGPGAAATVGK 26 2 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 RPVS(0.987)AIFT(0.012)ES(0.001)IQPQKPGPGAAATVGK;RPVS(0.778)AIFT(0.125)ES(0.097)IQPQKPGPGAAATVGK 78.025 6.5424e-05 30073000.0 1708.0 2433.3 2291.04 2260.1 1866.1799999999998 1871.2599999999998 2070.81 1668.69 1208.21 1619.22 True False 1747.7930768105377 2148.4081047895197 1979.9293517819053 1865.4159623313928 1697.3843485008392 1852.4368233681387 1914.6071344813033 1624.430920530976 2050.244125833012 1827.0626595384394 0.956613648517163 1.1758809111299227 1.083668007468383 1.020991782954309 0.9290236104598842 1.0138879549079665 1.047915420133965 0.8890942585085433 1.1221531539323086 1.0 10.835310397037578 -5.853596602718543 4.4450424457565285 0.996232246368439 1.0823881215988507 0.14087942834379896 0.07715040929971106 0.3343821757457121 11.771813328295217 0.02093047299764052 0.03233082524801862 1.400887942399173e-06 5.853596602718543 0.08615587523041168 RPVS(ph)FPETPYTVSPAGADR ddPTM_A459_Selumetinib_30min_R1 1 RPVSFPETPYTVSPAGADR 19 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 RPVS(0.89)FPET(0.107)PYT(0.003)VSPAGADR 98.804 0.0025508 11841000.0 1733.4 1700.1 1452.3 1521.3 1429.5 1753.5 1449.9 1582.4 1057.9 1065.1 True False 1773.784847390741 1501.0515016449524 1255.0856369128687 1255.6335133377947 1300.2019773987242 1735.8613820506132 1340.5328756788133 1540.4296116403982 1795.1790340410557 1201.8159599525643 1.47592052901407 1.2489861606632342 1.0443243214729874 1.0447801952866016 1.08186446238411 1.444365393615781 1.1154227605129525 1.2817516682847172 1.4937220788047376 1.0 10.231000270567728 -6.725607848796272 24.999991141876666 1.2751857065330945 1.1680954990512198 0.05476132104880971 0.17802692708118778 511.514512798683 356886.970356036 0.05976006002483705 0.059758278932909865 1.881014533936301e-07 6.725607848796272 -0.1070902074818747 RPVS(ph)FPETPYTVSPAGADR ddPTM_A459_Selumetinib_30min_R2 4 RPVSFPETPYTVSPAGADR 19 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 RPVS(0.999)FPET(0.001)PYTVSPAGADR;RPVS(0.983)FPET(0.017)PYTVSPAGADR;RPVS(0.997)FPET(0.003)PYTVSPAGADR;RPVS(0.997)FPET(0.003)PYTVSPAGADR 118.08 0.00023321 51742500.0 49776.2 55641.3 58129.2 66657.7 65426.0 66146.8 64374.0 64891.9 53596.0 59820.5 True False 47009.838073916275 59908.80879502181 54389.230558287556 57578.80626905371 57206.600964138874 75257.92127913429 67367.51855466104 65080.72468556766 64316.69759736149 58093.32673267519 0.8092123608317151 1.0312511292510553 0.9362388697167824 0.9911432088234657 0.9847361854035884 1.2954658566111121 1.1596429804177404 1.1202788400300432 1.1071271213873504 1.0 15.82608482816003 -6.5953753702245095 9.65501100179199 1.1453918104809742 0.9528961437011725 0.538903459158267 0.0863081381061701 0.2673011879692267 33.36780391387822 0.027685046068033136 0.027678062368345833 2.5387774360813923e-07 6.5953753702245095 -0.19249566677980168 RPVSFPET(ph)PYTVSPAGADR ddPTM_A459_Selumetinib_30min_R1 1 RPVSFPETPYTVSPAGADR 19 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 RPVS(0.113)FPET(0.437)PY(0.011)T(0.437)VS(0.001)PAGADR 136.33 0.022593 17066000.0 1331.8 1665.7 1089.1 1230.4 1295.4 1425.9 1338.7 1191.8 720.83 1213.7 True False 1362.82834876831 1470.6790696370786 941.2062019980766 1015.5337374684962 1178.2312987214452 1411.5567406136138 1237.720781206447 1160.1895924880105 1223.1958626598102 1369.4902174391395 0.9951355120423665 1.073887970070466 0.6872675613251717 0.7415414323787433 0.8603429828981645 1.0307169212593106 0.9037821266959519 0.847168952150306 0.8931760498056784 1.0 10.41942324526365 RPWRPEEAVEDPDEEDEDNT(ph)SEAENGFSLEEVLR ddPTM_A459_Selumetinib_30min_R1 2 RPWRPEEAVEDPDEEDEDNTSEAENGFSLEEVLR 34 2 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 RPWRPEEAVEDPDEEDEDNT(0.826)S(0.174)EAENGFSLEEVLR;RPWRPEEAVEDPDEEDEDNT(0.5)S(0.5)EAENGFSLEEVLR 83.22 1.379e-06 18603800.0 2359.84 2683.5099999999998 2642.92 3244.52 3135.16 2481.74 2353.09 2493.34 1542.5500000000002 2077.38 True False 2414.8196805506905 2369.3234016700458 2284.025980520388 2677.925489183423 2851.5853315574536 2456.7759488396287 2175.5945268163723 2427.2085236902635 2617.594686605567 2344.0319583947585 1.0301991284301468 1.0107897177701481 0.9744005291141749 1.142444103457242 1.2165300568300605 1.0480983162542201 0.9281420072046562 1.0354843990064309 1.116706057368838 1.0 11.194776524176227 -11.077240469291151 2.5990542262242333 0.9962258237529847 1.0548315305176854 0.04245474168731855 0.07945835486909973 16173685.825239874 14811696.270349167 426175.94395459286 0.022228763868638805 8.37065669684727e-12 11.077240469291151 0.05860570676470067 RQAS(ph)STFS(ph)Y(ph)Y(ph)GK ddPTM_A459_Selumetinib_30min_R2 1 RQASSTFSYYGK 12 1 E7EV90;Q5BKX6-2;Q5BKX6;Q5BKX6-3 E7EV90 SLC45A4 Solute carrier family 45 member 4 4 RQAS(0.97)S(0.347)T(0.34)FS(0.756)Y(0.794)Y(0.794)GK 47.621 0.047679 0.0 0.0 482.6 8814.8 8296.5 16660.0 7631.8 2057.0 4822.5 14699.0 5815.2 True False 0.0 519.6138681964211 8247.665364828581 7166.502387739222 14567.021857710295 8683.011175417358 2152.654575868173 4836.5326765921445 17639.210724375273 5647.300066295883 0.0 0.09201102510871903 1.4604616839916391 1.2690139187946141 2.579466592301149 1.5375508780273874 0.3811829636458683 0.8564327412771023 3.123476797283945 1.0 12.463345574854273 -5.258669406494542 4.807186097064802 1.51459956026004 0.016958684027942237 0.3783658089804921 0.7593764832996908 0.1918581769910521 13.24589836944815 0.20377720599830737 0.5106958428768652 5.512271416871767e-06 5.258669406494542 -1.4976408762320976 RQDLYSAR ddPTM_A459_Selumetinib_30min_R1 1 RQDLYSAR 8 1 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 137.05 0.0034584000000000004 773510.0 411.38 336.87 546.22 487.53 407.63 284.2 363.29 483.25 327.1 164.34 False True 420.9643535938636 297.42910379338576 472.0463241716915 402.3920375715342 370.75993847292165 281.3412060329539 335.8867428135428 470.4326401827744 555.0648095612339 185.43463980715845 2.2701494932750577 1.6039565428697422 2.5456210590566735 2.169993901840558 1.99941035212456 1.5171987624617107 1.8113484253149577 2.5369188878194375 2.993317808034518 1.0 7.5347669591426785 -6.26495805370039 22.177520775436697 2.0220024500862914 2.137052878694613 0.01860519679827355 0.5497920748408186 550.1683480083146 3467610.095618932 0.17283496581087854 0.20442594610698953 5.433028038184928e-07 6.26495805370039 0.11505042860832138 RQDLYSAR ddPTM_A459_Selumetinib_30min_R2 1 RQDLYSAR 8 1 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 93.598 0.032254000000000005 932040.0 4814.4 3642.8 3394.5 3941.4 4192.9 3809.8 3283.6 6414.2 3231.9 4491.6 False True 4546.8349215702 3922.1910465518517 3176.1015656521536 3404.574520705763 3666.1504169984078 4334.565368078968 3436.2939063299614 6432.86426007203 3878.370306830968 4361.915837421685 1.0423940055335457 0.8991899873222329 0.7281437065804409 0.7805227445007734 0.8404908654004333 0.9937297118142281 0.7877946375877679 1.4747795463826456 0.8891437733753846 1.0 12.090746218302888 -7.693787784885101 24.999999990057628 1.1365209617873686 0.8638023569587395 0.3277342330769889 0.16611510293321236 52.462845891448374 19386.499206002514 0.07444561666622988 0.042981169462543725 2.0240079551270833e-08 7.693787784885101 -0.2727186048286291 RQDPQVVS(ph)PFSR ddPTM_A459_Selumetinib_30min_R2 1 RQDPQVVSPFSR 12 1 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 RQDPQVVS(0.793)PFS(0.207)R 99.069 0.007548999999999998 7963800.0 7677.0 7242.4 30229.0 29098.0 42593.0 22357.0 9239.1 12457.0 22996.0 24975.0 True False 7250.343073465944 7797.8687920135935 28284.09905084663 25134.80220315021 37242.08655374875 25436.473813360655 9668.736456929339 12493.247807632633 27595.842561924874 24253.906857157046 0.29893505884089977 0.32150980202649426 1.1661667218162142 1.036319729896762 1.5355087645501961 1.048757792431888 0.3986465567742628 0.5151024897230535 1.1377895827031126 1.0 14.565929537136276 -5.2491639612846495 23.652511936741494 0.9660432159808808 0.3102221263421171 0.43431320447409916 0.30533787547726404 393.293881331026 757797.9416166492 0.08768055018368254 0.22779204570840272 5.634249031540279e-06 5.2491639612846495 -0.6558210896387637 RQDPQVVSPFS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RQDPQVVSPFSR 12 1 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 RQDPQVVS(0.486)PFS(0.514)R 83.869 0.017256 6113000.0 8958.6 13586.0 40133.0 41102.0 75380.0 32549.0 12967.0 16848.0 34431.0 38562.0 True False 8460.716876117238 14628.00251412469 37550.88647350651 35503.83669509521 65910.09049424977 37032.329299596364 13569.991193623046 16897.02489066345 41318.16208252024 37448.6148638915 0.2259287000832489 0.3906153156075533 1.0027309851108437 0.948068088075763 1.7600141082334462 0.9888838194467768 0.3623629670401356 0.45120560405441884 1.1033295151954958 1.0 15.192624737326907 -5.180625569962139 4.095765340945477 0.9420553879021226 0.265569774385607 0.34232319640276276 0.3587799717211937 0.29013925855512135 9.01610315784225 0.1042968089464262 0.30833272700318237 6.597424517051009e-06 5.180625569962139 -0.6764856135165156 RQDS(ph)MEALQMDR ddPTM_A459_Selumetinib_30min_R1 2 RQDSMEALQMDR 12 1 Q8TDR0-2;Q8TDR0 Q8TDR0-2 TRAF3IP1 TRAF3-interacting protein 1 1 RQDS(1)MEALQMDR;RQDS(1)MEALQMDR 183.28 0.00018729 49766000.0 8775.0 10306.5 9621.7 10430.7 10531.900000000001 8796.0 10317.0 9460.1 5230.6 9558.5 True False 8979.440426822293 9099.810188638137 8315.125988214937 8609.17405348881 9579.291504557976 8707.520226129005 9538.780383735646 9209.187417264497 8875.946172091068 10785.426582674474 0.8325531083996913 0.843713516464515 0.7709593982654533 0.7982228600321142 0.8881699236584658 0.8073412914531001 0.8844138255095613 0.8538547220800685 0.8229573586221649 1.0 13.396795618313758 -14.522878743313559 0.22345457517395018 1.8607548374460572 0.8140030037473451 0.6876215294505976 0.03398737223665262 90.24026829310765 0.9009458665682408 34.99911510513375 0.06372494842793089 3.0000000135860274e-15 14.522878743313559 -1.046751833698712 RQDS(ph)MEALQMDR ddPTM_A459_Selumetinib_30min_R2 1 RQDSMEALQMDR 12 1 Q8TDR0-2;Q8TDR0 Q8TDR0-2 TRAF3IP1 TRAF3-interacting protein 1 1 RQDS(1)MEALQMDR 193.98 0.00028571 30141000.0 52836.0 57490.0 61013.0 74183.0 84671.0 52406.0 47053.0 45130.0 50986.0 65343.0 True False 49899.58663926621 61899.29814051439 57087.49000593161 64079.1474271872 74033.87201165588 59624.450805697496 49241.05773375071 45261.32082832628 61184.62466786835 63456.37780849706 0.7863604630862566 0.9754622037727755 0.899633606226534 1.0098141375256176 1.1666892212959319 0.9396132093394329 0.7759828000639069 0.7132666942465412 0.9641997665311979 1.0 15.953477551815688 -7.05807677900779 8.406638720126972 0.8416235535746794 0.97508993024706 0.13708606645351862 0.11837745361073577 0.5898928518073645 80.13441584216318 0.04623842018034613 0.035936865113164636 8.748291003447789e-08 7.05807677900779 0.1334663766723806 RQDSDLVQCGVTS(ph)PSSAEATGK ddPTM_A459_Selumetinib_30min_R2 2 RQDSDLVQCGVTSPSSAEATGK 22 1 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 1 RQDSDLVQCGVT(0.112)S(0.765)PS(0.059)S(0.059)AEAT(0.005)GK;RQDSDLVQCGVT(0.054)S(0.8)PS(0.062)S(0.082)AEAT(0.002)GK 108.19 2.8693e-05 45410000.0 92871.0 85057.0 92953.0 110544.0 101460.0 77429.0 82566.0 88364.0 66673.0 84301.0 True False 87709.60161206928 91580.59839863874 86972.50517957419 95487.71650096339 88713.68773609161 88094.14191951975 86405.4826014253 88621.12461055235 80009.46299927002 81867.0110896975 1.071366847825559 1.118650811598564 1.062363264786629 1.1663759947989598 1.0836316918776059 1.0760639816567812 1.05543712236856 1.0825010395634784 0.9773101757875067 1.0 16.32099460400461 -7.979661452123407 0.9964303574251777 0.989083215995461 1.1002677541694779 0.5850948180740818 0.03271388640404417 0.3650080731912866 0.6736129527539902 0.029075385853765335 0.010840946854237516 1.0479451399511145e-08 7.979661452123407 0.11118453817401686 RQDSDLVQCGVTSPSS(ph)AEATGK ddPTM_A459_Selumetinib_30min_R1 1 RQDSDLVQCGVTSPSSAEATGK 22 1 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 1 RQDSDLVQCGVT(0.051)S(0.211)PS(0.3)S(0.431)AEAT(0.006)GK 85.73700000000002 0.00031482 20207000.0 6334.5 7290.7 9527.7 9270.0 6944.5 8349.9 7112.0 6643.7 4587.8 7338.3 True False 6482.081525208638 6437.1014546455235 8233.890671909896 7651.168519451357 6316.371201151053 8265.907587102603 6575.536114095947 6467.487494221002 7785.161520345541 8280.242286095114 0.7828371805126886 0.7774049637961985 0.994402142765429 0.9240271304983247 0.762824441956009 0.9982688068178172 0.7941236363503693 0.7810746679576944 0.9402093865561212 1.0 13.01545726734247 -8.50328953336986 7.464279617814128 0.9999812739166253 0.8566461948663473 0.24533559857170317 0.08586457034769819 0.23284946187913938 66.03453247420482 0.08368331774573678 0.021640361161490096 3.138415692301191e-09 8.50328953336986 -0.14333507905027798 RQEEEDLLR ddPTM_A459_Selumetinib_30min_R2 1 RQEEEDLLR 9 1 Q70UQ0-4 Q70UQ0-4 0 108.43 0.016253999999999998 3321500.0 17975.0 11289.0 20832.0 18709.0 26100.0 16437.0 18935.0 17627.0 15611.0 15316.0 False True 16976.021459626194 12154.830000143804 19491.69180016663 16160.801925174836 22821.084663039524 18701.047549770068 19815.515018990693 17678.291651693067 18733.636207784344 14873.787284252954 1.141338190146023 0.8171980523758235 1.3104726743539423 1.0865290471300781 1.5343156539021143 1.2573157859779989 1.3322440774697377 1.1885534809556726 1.2595067987571569 1.0 13.860484424419294 -5.276228974966883 24.844968419270643 1.2609203875344703 0.9792681117545674 0.31983451918878936 0.15445538711953924 664.6281163936803 1116505.5324221426 0.038170055809918176 0.07999509171147337 5.293842607364694e-06 5.276228974966883 -0.2816522757799029 RQEMESGITT(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 RQEMESGITTPPK 13 1 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 RQEMESGIT(0.069)T(0.931)PPK 107.11 0.0084009 6804800.0 59027.0 51713.0 53472.0 61385.0 55582.0 51685.0 57748.0 60989.0 34418.0 50807.0 True False 55746.51564380283 55679.22081649717 50031.6697359116 53024.25710496859 48599.29225061549 58804.13960028385 60433.39642549116 61166.46789272754 41302.561719269856 49340.06989756069 1.1298426564766353 1.1284787583823404 1.014017001592961 1.074669274183376 0.9849862870384417 1.1918130582784412 1.2248340253867156 1.2396915533301978 0.8370997812735528 1.0 15.59047213898142 -8.268231491839854 24.998527352674156 0.918549886625902 1.1194598755283944 0.47068592479294713 0.08686731325953391 562.9365558673597 2071871.4007444603 0.08333566282351405 0.023443291525283516 5.3922312398108865e-09 8.268231491839854 0.20090998890249245 RQEQPSIESTS(ph)PISR ddPTM_A459_Selumetinib_30min_R1 2 RQEQPSIESTSPISR 15 1 Q5T5P2-3;Q5T5P2 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 RQEQPSIES(0.001)T(0.098)S(0.901)PISR;RQEQPSIES(0.001)T(0.11)S(0.89)PISR 170.42 9.4583e-05 17607400.0 4957.1 5814.7 6539.9 6803.700000000001 6522.0 5348.0 5983.9 5263.8 3308.5 4456.5 True False 5072.59078516248 5133.912220819308 5651.817501099275 5615.561516266584 5932.08625155262 5294.2039755954875 5532.529605334474 5124.186924767903 5614.282856720704 5028.535184986015 1.0087611199993198 1.0209558115746953 1.1239490812303015 1.1167390322798747 1.1796847458210868 1.0528322425589651 1.100226885525881 1.0190217898976786 1.116484751560174 1.0 12.29592248804744 -10.468301362579517 14.819131256687932 1.0000000005834488 1.0832169403007712 0.17795857011477434 0.05286712161538598 0.0 0.0 0.053634376132071476 0.013008246938625739 3.4017205797549605e-11 10.468301362579517 0.08321693971732236 RQEQPSIESTS(ph)PISR ddPTM_A459_Selumetinib_30min_R2 1 RQEQPSIESTSPISR 15 1 Q5T5P2-3;Q5T5P2 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 RQEQPS(0.001)IES(0.006)T(0.013)S(0.979)PISR 147.53 0.00089796 0.0 13058.0 12964.0 13231.0 11177.0 11331.0 10226.0 8795.3 9595.9 8855.9 12745.0 True False 12332.28863531566 13958.297114169925 12379.731864823587 9654.67331859956 9907.498479574748 11634.538677614451 9204.298877556314 9623.822480313233 10627.327454520375 12377.018734513184 0.9963860360756508 1.127759229712351 1.0002192070940992 0.7800483723659242 0.800475356149199 0.9400113975081629 0.7436604141100817 0.777555781949114 0.8586338667231864 1.0 13.595376232478698 -5.628985975917187 4.782546071953774 0.8323605929973356 1.0625222671621095 0.5671783427591159 0.08008666106257632 0.1314796006615128 4.952595186883662 0.02118494253239863 0.03771815534775211 2.349708695580007e-06 5.628985975917187 0.23016167416477396 RQGLAETAS(ph)PVAVSLR ddPTM_A459_Selumetinib_30min_R1 4 RQGLAETASPVAVSLR 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 RQGLAET(0.017)AS(0.983)PVAVSLR;RQGLAET(0.015)AS(0.978)PVAVS(0.006)LR;RQGLAET(0.004)AS(0.974)PVAVS(0.022)LR;RQGLAETAS(0.998)PVAVS(0.002)LR 105.95 0.0018375 38950800.0 6172.700000000001 6944.599999999999 8847.4 9957.6 8912.0 6711.4 6617.0 6068.9 3973.0699999999997 5363.2 True False 6316.511900016633 6131.5230035430495 7645.971675289486 8218.692087301932 8105.9111735413935 6643.88940946364 6117.87436262274 5907.933057434539 6742.009608448337 6051.618961991924 1.0437722433762615 1.0132037463120158 1.2634588732884748 1.358098079029864 1.339461592749271 1.0978697520765197 1.0109483761365252 0.9762566173680421 1.1140836279997983 1.0 12.563105436302859 -6.992161878535965 24.175270821033745 1.027781450917249 1.206303818005106 0.37453375727283267 0.1090419080497841 151.8036641130406 468207.00554150034 0.04393428311211897 0.03866852229193611 1.0182117899629275e-07 6.992161878535965 0.17852236708785707 RQGLAETAS(ph)PVAVSLR ddPTM_A459_Selumetinib_30min_R2 1 RQGLAETASPVAVSLR 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 RQGLAET(0.001)AS(0.999)PVAVSLR 73.44800000000002 0.017797 19480000.0 21011.0 26416.0 29496.0 31498.0 31798.0 19161.0 14693.0 14623.0 22488.0 32796.0 True False 19843.292733697126 28442.02225917252 27598.259472816593 27207.918062919278 27803.250962273207 21800.253823760075 15376.253613627161 14665.550509032024 26986.228367218915 31849.09426575867 0.6230410374662013 0.8930245243975703 0.8665320037841013 0.8542760379899037 0.8729683403325162 0.6844858331559457 0.482784643271892 0.46046993947953885 0.8473154100407848 1.0 14.958964724813496 -6.86287587835436 5.484619147308449 0.6439915096460352 0.8296474366313537 0.09197630026465575 0.16694093533742393 0.32812429148841255 14.913934573453064 0.058098417986011494 0.051339592078245185 1.37127362105955e-07 6.86287587835436 0.1856559269853184 RQGS(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R1 2 RQGSFSEDVISHK 13 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 RQGS(0.99)FS(0.01)EDVISHK;RQGS(0.816)FS(0.184)EDVISHK 118.23 0.0017774999999999996 38940100.0 8444.9 8010.9 9666.4 11103.7 9297.4 7478.0 7649.299999999999 7893.1 4084.9 6545.0 True False 8641.649739085078 7072.980103833625 8353.75597373446 9164.64723726344 8456.451811589293 7402.778109480744 7072.307142513236 7683.749347597843 6931.776950708298 7385.114503698745 1.170144313234008 0.9577346566923518 1.1311613339983535 1.240962104605614 1.1450671221622877 1.0023917849578572 0.9576435326725343 1.0404374019860532 0.9386146886736287 1.0 12.850404574323472 -6.801465506272816 6.515359755880465 0.9874603506811396 1.1258563816426408 0.49798573875887153 0.07089728561324088 0.18399697915606458 20.547301623314493 0.026586320604889056 0.02377577112664423 1.5795540584301367e-07 6.801465506272816 0.13839603096150122 RQGS(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R2 2 RQGSFSEDVISHK 13 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 RQGS(0.753)FS(0.247)EDVISHK;RQGS(0.952)FS(0.048)EDVISHK 122.01 0.0014017 29118800.0 232030.0 209352.0 234053.0 234360.0 247602.0 174327.0 173604.0 183289.0 147121.0 212015.0 True False 219134.701489684 225408.62522722158 218994.28479763863 202439.76370645035 216496.02317003513 198338.96186705373 181676.92998979992 183822.3406448727 176549.3109041985 205893.57606887538 1.0643105320409765 1.09478221482645 1.0636285452848748 0.9832252543844804 1.0514947931042444 0.9633081597490225 0.8823827020665543 0.8928027000870613 0.8574784812379933 1.0 17.65153929266267 -6.922039619421548 2.3098638867149295 0.8986693898259757 1.05334726859719 0.7006750954508472 0.044087441643950454 0.1615426383777487 1.7503739772772922 0.018120577759115148 0.015087348681229682 1.1966313611314615e-07 6.922039619421548 0.15467787877121442 RQGS(ph)VVSSR ddPTM_A459_Selumetinib_30min_R2 2 RQGSVVSSR 9 1 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 1 RQGS(1)VVSSR;RQGS(0.802)VVS(0.099)S(0.099)R 89.189 0.015504 11734000.0 3109.89 2792.04 3388.25 2169.1000000000004 2921.59 1477.46 3198.0 5768.5 4411.87 5644.0 True False 2937.0547636760457 3006.1804901764112 3170.2536838476694 1873.6648380937913 2554.553744854011 1680.966703953476 3346.7133367167826 5785.285379973417 5294.367277947444 5481.043055126905 0.5358569042672924 0.5484686874270153 0.5784033535153953 0.3418445757949642 0.46607073127522886 0.30668737447357197 0.6105978922362789 1.055508107085918 0.9659415597903676 1.0 12.420234752166397 -7.655916830270786 4.133004847867935 1.0085310558559013 0.46610514809310444 0.8907085331441521 0.0850981466369475 0.06894258652950541 2.1265608719824227 0.04577558436217701 0.02480307045530595 2.2084276182925268e-08 7.655916830270786 -0.5424259077627969 RQIS(ph)EETESVDNR ddPTM_A459_Selumetinib_30min_R1 1 RQISEETESVDNR 13 1 P46934-3;P46934-2;P46934;H0Y8X6;P46934-4 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 RQIS(1)EETESVDNR 185.66 0.00022851 5865400.0 887.45 975.53 1180.3 1475.5 1189.6 1007.3 943.71 1014.7 588.56 1021.0 True False 908.1258583228994 861.3144940884066 1020.0217429238171 1217.831623565316 1082.0008900409377 997.1674765552233 872.5251949147205 987.786859789884 998.743333278385 1152.0552953821882 0.7882658601223073 0.7476329456935226 0.8853930423412796 1.057094766585233 0.939191803013231 0.8655552216566291 0.7573639897425799 0.8574127159948438 0.8669230871831175 1.0 10.16999424836867 -5.297756215166255 6.992831422526436 0.8989885452811566 0.7679284945510604 0.32199230235084897 0.07856460179956694 0.26300976800102044 41.501338326891556 0.022775571264459275 0.04897592420167745 5.037833208060103e-06 5.297756215166255 -0.1310600507300962 RQLAELETEDGMQES(ph)P ddPTM_A459_Selumetinib_30min_R1 2 RQLAELETEDGMQESP 16 1 Q96QG7-2;Q96QG7 Q96QG7-2 MTMR9 Myotubularin-related protein 9 1 RQLAELETEDGMQES(1)P;RQLAELETEDGMQES(1)P 117.08 0.003358 13591100.0 2539.8 3071.8 2929.7 3282.5 3055.8 2438.3999999999996 2794.3999999999996 2379.7 1503.35 2219.95 True False 2598.9723984094885 2712.152227958924 2531.862831690168 2709.2729951563215 2779.4034295453102 2413.8719098900588 2583.616158215653 2316.582625645004 2551.0751496602907 2504.9022066441607 1.0375544368621696 1.0827377694686204 1.010763144754512 1.0815883302629838 1.1095856046487744 0.9636591414576395 1.03142396192662 0.9248195875672728 1.018433032193296 1.0 11.290538565230866 -6.772582892918338 24.99997186749376 0.9857031626287797 1.0634320643463073 0.5153779644735115 0.037195391361993 175.14748128258216 392932.91490778635 0.012660201518745955 0.011267172452860687 1.6881736104167816e-07 6.772582892918338 0.07772890171752767 RQLAELETEDGMQES(ph)P ddPTM_A459_Selumetinib_30min_R2 1 RQLAELETEDGMQESP 16 1 Q96QG7-2;Q96QG7 Q96QG7-2 MTMR9 Myotubularin-related protein 9 1 RQLAELETEDGMQES(1)P 113.67 0.0040066 3143000.0 5578.1 5148.4 6404.5 6811.9 5182.1 5090.4 4494.4 4766.0 3622.0 6497.9 True False 5268.091532903525 5543.2657252848185 5992.441442692359 5884.107468817061 4531.078269438209 5791.556393949593 4703.398505484647 4779.868270946225 4346.5012071356705 6310.288743428257 0.8348415971281646 0.8784488239239067 0.9496303079527201 0.9324624764508542 0.718046107502929 0.9177957823215478 0.745353928595252 0.7574721958522322 0.6887959305605882 1.0 12.623490305588026 -6.245371351751508 24.945585461607923 0.7951506838647199 0.9010163425014728 0.19384436694510598 0.09295239148369659 1194.869837397945 1855032.6528921586 0.026641114728489568 0.034283385697710056 5.683667302301378e-07 6.245371351751508 0.1058656586367529 RQLEEAEEEAQR ddPTM_A459_Selumetinib_30min_R1 1 RQLEEAEEEAQR 12 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 148.89 0.00079927 4142400.0 1532.5 1581.0 1730.7 2049.1 2125.9 1510.9 1634.1 1528.5 1111.8 1188.4 False True 1568.2042682740914 1395.8957850130398 1495.680446054606 1691.2631513708495 1933.612720358129 1495.7017177874386 1510.8385213785416 1487.959214732273 1886.643397340813 1340.94271599627 1.1694789416183038 1.040980922123837 1.1153947355188634 1.2612493667295137 1.4419801064518463 1.1154105987862342 1.1266987794150816 1.109636673500087 1.4069530150951362 1.0 10.38903189243892 -5.669642933739078 6.6390019550774815 1.2155944122722424 1.0993857774399483 0.10624254113633147 0.13191540717123826 0.4542917599056155 27.41095102749181 0.03617113034762559 0.06294514565714661 2.1397205922442527e-06 5.669642933739078 -0.11620863483229416 RQLEEAEEEAQR ddPTM_A459_Selumetinib_30min_R2 3 RQLEEAEEEAQR 12 1 P35579;P35579-2 P35579;P35579-2 MYH9 Myosin-9 0 ;; 164.13 0.00068636 8837700.0 50300.3 45106.6 54962.0 53031.0 61091.0 37013.1 41821.0 37190.5 40156.0 42798.8 False True 47504.81069405484 48566.1311794212 51425.80475810093 45808.086316422385 53416.20241953055 42111.31855353131 43765.75936673935 37298.7181977813 48188.32205238544 41563.08743936308 1.1429567344668563 1.168491904030829 1.2372951079037786 1.1021338677799715 1.2851836980941354 1.0131903366170294 1.052995868764316 0.8974000849238373 1.1594018880981352 1.0 15.343015205784276 -6.784110769779083 24.999646196652034 1.0199599549440035 1.1842280431177756 0.5333892579949848 0.07595995690770996 177.07837514837973 195262.23167601955 0.025023406569164307 0.02208375317657421 1.643952368437943e-07 6.784110769779083 0.16426808817377214 RQLEEAEEESQR ddPTM_A459_Selumetinib_30min_R1 4 RQLEEAEEESQR 12 1 P35749-4;P35749-3;P35749;P35749-2 P35749-4 MYH11 Myosin-11 0 ;;; 227.48 1.1325999999999998e-09 140884000.0 7986.8 9018.1 10879.8 12087.400000000001 10204.1 8838.5 8949.2 8254.2 6278.3099999999995 6694.7699999999995 False True 8172.876900392509 7962.256659599053 9402.382918463569 9976.562498599398 9281.14095668018 8749.59271471591 8274.154638957745 8035.271802579735 10653.833520380282 7554.108942082087 1.0819114422434943 1.0540298956033418 1.244671342517342 1.3206802516472085 1.2286215393290425 1.1582560937100173 1.0953184157650229 1.0636955151410654 1.4103362292050607 1.0 12.88304587451222 -9.898222061019828 15.229691995450002 1.0000035661628563 1.1805245655646421 0.19438931997069364 0.11225666769637442 0.0 0.0 0.11193133379935667 0.0271473360041774 1.2640898348717704e-10 9.898222061019828 0.1805209994017858 RQLHLEGASLELS(ph)DDDTESK ddPTM_A459_Selumetinib_30min_R1 3 RQLHLEGASLELSDDDTESK 20 1 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 1 RQLHLEGASLELS(0.988)DDDT(0.009)ES(0.003)K;RQLHLEGASLELS(0.998)DDDT(0.002)ESK;RQLHLEGASLELS(0.998)DDDT(0.002)ESK 167.28 1.5765e-09 33382000.0 7490.65 8792.9 8182.110000000001 7742.76 7882.380000000001 7099.25 8458.21 7862.66 3499.82 6334.26 True False 7665.1675707323475 7763.423180291693 7071.024403113105 6390.632315605957 7169.420120747217 7027.83799060326 7820.200409956059 7654.116715280899 5938.9389232607655 7147.323971917312 1.072452795039053 1.08619998348964 0.9893247362084052 0.8941293749542505 1.0030915275306846 0.9832824170579749 1.0941438279113356 1.0709066421719284 0.8309318209997987 1.0 12.803187468497937 -5.26529476376305 21.93934092689856 0.987249443156718 1.0793264084868315 0.21957215749711845 0.07215231712743096 89.57791777262818 509776.1139059461 0.019257265527553316 0.04287160461187197 5.428817424608679e-06 5.26529476376305 0.09207696533011345 RQLHLEGASLELS(ph)DDDTESK ddPTM_A459_Selumetinib_30min_R2 4 RQLHLEGASLELSDDDTESK 20 1 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 1 RQLHLEGASLELS(0.972)DDDT(0.027)ES(0.002)K;RQLHLEGASLELS(0.989)DDDT(0.01)ES(0.001)K;RQLHLEGASLELS(0.71)DDDT(0.245)ES(0.045)K;RQLHLEGASLELS(0.967)DDDT(0.029)ES(0.004)K 156.2 8.714e-07 17074600.0 79461.4 73093.2 85524.0 90857.2 84570.5 62538.6 67176.2 67120.4 53830.4 73680.7 True False 75045.25349718724 78699.21340831887 80021.47895149078 78482.29262258773 73945.99772013734 71152.72448111269 70300.0264071151 67315.70925161967 64597.98414704469 71553.34674555078 1.0488014455012697 1.0998676789805422 1.118347115698911 1.0968360837359128 1.0334387011008026 0.9944010688156526 0.9824841129668948 0.9407765298665837 0.9027947270832782 1.0 16.126731626868832 -6.769425029416088 1.3212264969474337 0.9475830586901612 1.0948469229120086 0.8092992871745653 0.02942726848115692 0.17534874316071453 0.6414996781846215 0.014455272588659815 0.012951380526076457 1.7004934779470193e-07 6.769425029416088 0.14726386422184734 RQLHLEGASLELSDDDTES(ph)K ddPTM_A459_Selumetinib_30min_R2 1 RQLHLEGASLELSDDDTESK 20 1 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 1 RQLHLEGASLELS(0.272)DDDT(0.272)ES(0.455)K 55.128 0.023376 3562800.0 14398.0 13411.0 15045.0 15481.0 15730.0 13067.0 11519.0 13723.0 7309.2 12607.0 True False 13597.816799760658 14439.580576838385 14077.021079757447 13372.461093785438 13753.85677201578 14866.860639584198 12054.656324465479 13762.931658035044 8771.244236111546 12243.003153080243 1.110660238320657 1.1794149193864663 1.1498013113078207 1.0922533406700163 1.1234054749512516 1.2143148583477914 0.9846159617652817 1.1241467053426675 0.7164291413177306 1.0 13.579669867533013 -8.240622158767493 24.654358039797927 0.8582145952657727 1.122654830587589 0.6055763507866555 0.08525964121063798 360.1687427969237 426558.55456185836 0.05441004080995438 0.02051430391857583 5.7461616752635344e-09 8.240622158767493 0.26444023532181626 RQLLS(ph)LLR ddPTM_A459_Selumetinib_30min_R2 1 RQLLSLLR 8 1 A0A0B4J229 A0A0B4J229 ADAMTS13 1 RQLLS(1)LLR 70.41199999999998 0.036667 6424800.0 12494.0 18883.0 16674.0 20909.0 20138.0 15074.0 12363.0 12935.0 7713.6 21044.0 True False 11799.633497444773 20331.2653815852 15601.21299327855 18061.158129963158 17608.08440399579 17150.30667185217 12937.90399681976 12972.63870849548 9256.535535991641 20436.40504112165 0.577383031590039 0.9948552761933965 0.7634030037027628 0.8837737407152053 0.8616038079380997 0.8392036973891802 0.6330812083038292 0.6347808571219961 0.45294343684057253 1.0 14.318853814303923 -7.259941069916486 24.67719814915857 0.6497664401031514 0.8301956192652319 0.14017792159676357 0.16165775714162253 168.16518123529204 2769719.326372162 0.05990817692789254 0.043863159525563036 5.496154469599549e-08 7.259941069916486 0.18042917916208046 RQLQEDQENNLQDNQTSNSS(ph)PCR ddPTM_A459_Selumetinib_30min_R2 2 RQLQEDQENNLQDNQTSNSSPCR 23 1 Q92576-2;Q92576 Q92576-2 PHF3 PHD finger protein 3 1 RQLQEDQENNLQDNQT(0.001)S(0.002)NS(0.021)S(0.977)PCR;RQLQEDQENNLQDNQT(0.293)S(0.078)NS(0.234)S(0.395)PCR 130.69 3.9802e-06 7593600.0 26219.0 20926.0 25789.1 26657.1 29889.5 19808.2 17814.4 22007.0 23362.9 25863.2 True False 24761.852942972986 22530.956912304817 24129.85738304903 23026.356993937585 26134.51379447971 22536.599749063418 18642.804898563936 22071.036726545033 28036.132813967397 25116.462215336298 0.9858814004407521 0.8970593357908204 0.9607187977419511 0.9167834544738359 1.0405332395309155 0.8972840026531445 0.7422544122149696 0.8787478322909783 1.1162452965548757 1.0 14.6163456469704 RQLS(ph)MTLR ddPTM_A459_Selumetinib_30min_R2 1 RQLSMTLR 8 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;E5RIY8;E5RIU4;E5RJQ8;E5RGV7 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 RQLS(0.932)MT(0.068)LR 70.41199999999998 0.036667 1514300.0 6029.0 5198.0 4799.2 6219.6 6499.0 4070.0 4673.9 4483.1 4721.6 6399.8 True False 5693.932315999238 5596.669885795681 4490.424696973875 5372.479750591556 5682.537518202836 4630.60555621854 4891.245611157152 4496.145078782844 5666.0519325267205 6215.021145322673 0.9161565476385228 0.9005069741408115 0.7225115718798959 0.8644346696446559 0.9143231189936375 0.7450667420019095 0.7870038567508698 0.7234319841641363 0.911670580041534 1.0 12.601543584419375 -5.033351708555413 24.731837065133853 0.8220868727531118 0.9122442485321558 0.0943482494005502 0.08763870988555014 901.2550832946116 668323.693532152 0.021423033485694857 0.056769741687500604 9.260795443997724e-06 5.033351708555413 0.09015737577904404 RQNEEVSIS(ph)LDFTY(ph)PS(ph)LEES(ph)IPSK ddPTM_A459_Selumetinib_30min_R1 1 RQNEEVSISLDFTYPSLEESIPSK 24 1 P40818;P40818-2;A0A075B720 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 4 RQNEEVS(0.069)IS(0.505)LDFT(0.506)Y(0.93)PS(0.988)LEES(0.882)IPS(0.121)K 45.369 0.040852 0.0 154.18 309.14 171.1 181.02 170.66 199.44 115.64 194.87 0.0 196.25 True False 157.7720940179442 272.94574508471317 147.86555978502508 149.40825516624434 155.22383313247016 197.4338146770313 106.91718169770186 189.7014145730311 0.0 221.44059913687997 0.7124804332760132 1.232591250875347 0.6677436764593666 0.6747103094400951 0.7009727833897389 0.8915881525184582 0.4828255618637155 0.8566695326531798 0.0 1.0 7.7907759412698585 -5.7579862691807016 0.6623278901808033 0.6031723937314966 0.9897841193308741 0.11093188467921522 0.29352721926726394 2.4441916208314183 1.7901278847077051 0.1580645125508041 0.6047743245412265 1.7458773503693755e-06 5.7579862691807016 0.3866117255993775 RQPPVSPLT(ph)LSPGPEAHQGFSR ddPTM_A459_Selumetinib_30min_R2 1 RQPPVSPLTLSPGPEAHQGFSR 22 1 Q6UUV7;Q6UUV7-3 Q6UUV7 CRTC3 CREB-regulated transcription coactivator 3 1 RQPPVS(0.014)PLT(0.685)LS(0.301)PGPEAHQGFSR 70.02 0.0024017 4121000.0 7160.0 7657.9 9567.0 9956.9 10270.0 8547.4 6494.2 5880.4 5355.0 10558.0 True False 6762.075863750961 8245.23630597052 8951.469635762016 8600.75304338946 8979.790785035091 9724.726764428095 6796.193168013168 5897.510990447377 6426.149631201412 10253.163107021584 0.6595111960249757 0.8041651361543256 0.8730446928745198 0.8388389956948488 0.8758068794288018 0.9484611395451609 0.6628386866643124 0.5751894248525741 0.6267480156246269 1.0 13.32378143023976 -7.286367624705941 24.65792060629226 0.6807931221693706 0.8359699977288958 0.1451644234565651 0.12808656232971677 940.0244143289584 929825.9444960733 0.052321853145125406 0.03529395143633362 5.171688698002214e-08 7.286367624705941 0.1551768755595252 RQPS(ph)MSETMPLYTLCK ddPTM_A459_Selumetinib_30min_R1 2 RQPSMSETMPLYTLCK 16 1 K7EJD2;A0A0A0MR03;Q9Y5B0 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 RQPS(0.982)MS(0.012)ET(0.006)MPLYTLCK;RQPS(0.949)MS(0.043)ET(0.009)MPLYTLCK 106.73 0.0017668 49937000.0 5782.200000000001 6218.5 5666.8 5201.8 5702.6 4867.3 6277.6 5609.1 3286.2 5396.2 True False 5916.91400979736 5490.43512909778 4897.279685504271 4293.403279879402 5186.800836875804 4818.339381154807 5804.075577875242 5460.328447075432 5576.441385448258 6088.854833439141 0.9717613856225468 0.9017188419315036 0.8043022570696043 0.7051249204202785 0.8518516172188271 0.7913375360327461 0.9532294227151006 0.8967742862070008 0.9158440360284532 1.0 12.571955202207304 -8.000973865387744 0.9234041686381766 0.9810621678526087 0.8371373584856774 0.30052512582198243 0.0725160319828885 0.7442115066871033 1.2063705209478897 0.07268559734057735 0.027834327500075296 9.977601043940162e-09 8.000973865387744 -0.1439248093669313 RQPS(ph)MSETMPLYTLCK ddPTM_A459_Selumetinib_30min_R2 1 RQPSMSETMPLYTLCK 16 1 K7EJD2;A0A0A0MR03;Q9Y5B0 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 RQPS(0.854)MS(0.102)ET(0.044)MPLYTLCK 102.24 0.0025899 14460000.0 86793.0 71716.0 83307.0 88214.0 111180.0 86555.0 87478.0 90285.0 92539.0 107120.0 True False 81969.39251990744 77216.3865967147 77947.11831780367 76199.10102236198 97212.57443818907 98477.1655819399 91545.90033436847 90547.71440251358 111049.38575569516 104027.16726881522 0.7879614015451505 0.7422713568387463 0.7492957884393945 0.7324923192944098 0.9344921811336393 0.9466485358335902 0.8800191597816552 0.8704237246846339 1.067503698036244 1.0 16.666600819780804 -6.266244780219432 23.92271022347632 0.9397176813470395 0.7519735472246947 0.7537384989091047 0.05493640050057047 114.01106073719511 567580.2552163954 0.01674344410718211 0.01962146420627748 5.416954899857545e-07 6.266244780219432 -0.1877441341223448 RQQDPS(ph)PGSNLGGGDDLK ddPTM_A459_Selumetinib_30min_R1 2 RQQDPSPGSNLGGGDDLK 18 1 J3KTD8;Q13951-2 J3KTD8 CBFB 1 RQQDPS(0.986)PGS(0.014)NLGGGDDLK;RQQDPS(0.998)PGS(0.002)NLGGGDDLK 97.662 0.0017767 17019900.0 3644.5 4185.200000000001 5387.3 5481.3 4491.0 4340.2 3739.2999999999997 3867.6000000000004 2410.69 3234.6 True False 3729.409759037475 3695.1948383533063 4655.734250320664 4524.093851744202 4084.789842950447 4296.541528586298 3457.2415904722966 3765.018684264665 4090.764860168665 3649.7924176721117 1.0218142108520638 1.0124397268352463 1.2756161769030567 1.239548263029636 1.119184155014433 1.177201615024093 0.9472433483429102 1.0315706356434502 1.1208212391371595 1.0 11.833598697555761 -7.246313407324461 24.885077817812846 1.0275396877726186 1.1447364013211219 0.29669694711331007 0.08738514070933634 1071.3352408858877 1762551.3702554645 0.03635249868944046 0.028048882472585017 5.671351862735864e-08 7.246313407324461 0.11719671354850325 RQQDPS(ph)PGSNLGGGDDLK ddPTM_A459_Selumetinib_30min_R2 2 RQQDPSPGSNLGGGDDLK 18 1 J3KTD8;Q13951-2 J3KTD8 CBFB 1 RQQDPS(0.998)PGS(0.002)NLGGGDDLK;RQQDPS(0.995)PGS(0.005)NLGGGDDLK 88.62700000000002 0.0033013000000000005 13960600.0 82908.0 78919.0 90089.0 91851.0 88061.0 71985.0 54326.0 56589.0 54702.0 90813.0 True False 78300.30526702029 84971.83353541918 84292.77182148682 79340.7353481872 76997.98990467143 81900.28033523142 56852.266644926756 56753.66462118674 65643.9285015836 88190.99272948972 0.8878492331659383 0.9634978687228895 0.9557979699813562 0.8996466973849685 0.8730822448143786 0.928669445715914 0.6446493557376208 0.6435313047815276 0.7443382421483196 1.0 16.428343695104637 -7.246844517482494 24.4227438313184 0.7284240032720213 0.9189843401396379 0.3783003293225723 0.09752568716897403 499.82013745842943 836389.855403819 0.03573835931107652 0.02754992401413262 5.664420456364892e-08 7.246844517482494 0.19056033686761664 RQQEELLAEENQR ddPTM_A459_Selumetinib_30min_R1 1 RQQEELLAEENQR 13 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 154.1 0.00020119 0.0 1141.0 1145.8 1254.9 1272.8 1082.7 1175.0 1029.3 1213.2 789.51 815.57 False True 1167.5830800004817 1011.6492033320318 1084.491472672285 1050.5293734150691 984.7699761662102 1163.1805668146408 951.6590723058154 1181.0219949710138 1339.7408064710778 920.2563538245361 1.2687585096783836 1.0993123808683003 1.1784667045929067 1.1415616627357426 1.0701039683926756 1.2639745023009346 1.034123881188944 1.2833619567664485 1.455834345400808 1.0 9.845891995372384 -7.808520535002941 24.992379898596003 1.2771990745792 1.1508585048258981 0.09294122407755767 0.12614969286948688 211.57519859061264 112308.9915614727 0.06386261801335456 0.030678734971112634 1.5541018055191098e-08 7.808520535002941 -0.12634056975330177 RQQEEMMR ddPTM_A459_Selumetinib_30min_R1 2 RQQEEMMR 8 1 Q15233-2;Q15233;H7C367 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 0 ; 184.49 0.00093105 5115400.0 810.98 895.02 1768.3400000000001 1710.58 1546.87 1455.7800000000002 1017.29 1487.95 716.0799999999999 885.1099999999999 False True 829.8742561076174 790.2306423164907 1528.209140796325 1411.8593145634418 1406.95588162208 1441.136174942483 940.554996275122 1448.4847324572368 1215.1354595860848 998.7224902014968 0.8309357847145171 0.7912414610359461 1.5301639402232765 1.413665285817878 1.4087555806800947 1.4429795955147933 0.9417581014775793 1.4503375528921936 1.216689792718021 1.0 9.963940049345775 -5.247347406830671 24.849448683861638 1.3168052001292672 0.8110885100114481 0.5220809044469408 0.18680106757775672 541.3843316811634 954660.0894762297 0.04661293912406734 0.12200330837719023 5.657865162162886e-06 5.247347406830671 -0.5057166901178191 RQQEEMMR ddPTM_A459_Selumetinib_30min_R2 2 RQQEEMMR 8 1 Q15233-2;Q15233;H7C367 Q15233-2 NONO Non-POU domain-containing octamer-binding protein 0 ; 176.6 0.00022809 8812300.0 20825.0 23245.0 23893.0 27828.0 24151.9 13949.8 14207.6 15523.7 15077.300000000001 25371.0 False True 19667.629869080134 25027.81675554458 22355.750392731454 24037.778394022425 21117.7224012745 15871.258326323687 14868.281551825303 15568.871396913117 18093.181294960417 24638.473308225475 0.7982487235730698 1.0158022553771269 0.9073512840289524 0.975619637357867 0.8571035281729252 0.6441656561985567 0.603457907713039 0.6318926989569398 0.7343466889614491 1.0 14.588625243581866 -6.614401080629562 4.4882982167946395 0.6932207392624941 0.928452748460365 0.38720112604244117 0.11738634782956138 0.18333401155859302 6.624254644551584 0.03766345723272018 0.0377024051965237 2.4299588513712023e-07 6.614401080629562 0.2352320091978709 RQQVLDR ddPTM_A459_Selumetinib_30min_R2 2 RQQVLDR 7 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2;A0A0D9SFF6 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 ; 133.6 0.0043011 3665500.0 14097.2 11567.9 11096.9 12609.900000000001 13334.6 10701.4 14174.599999999999 11755.0 11856.4 15267.0 False True 13313.734059562856 12455.120733338956 10382.937535391186 10892.409866709186 11659.388335163487 12175.42071236293 14833.746986437052 11789.205103854993 14228.011295495133 14826.202041570232 0.8979868223995151 0.8400749361445936 0.7003099988978388 0.7346729685841769 0.7864042525842073 0.8212096852737506 1.0005088926244001 0.7951601543537583 0.9596531367643668 1.0 13.855861456267487 -7.074619890772391 6.1800621944357506 0.9214742788493601 0.7878067484809784 0.4641233905854739 0.07430674890511008 0.24004048542754122 15.82705172958765 0.02919044459640523 0.022686112835593564 8.421318815097858e-08 7.074619890772391 -0.13366753036838164 RQS(ph)FAVLR ddPTM_A459_Selumetinib_30min_R1 3 RQSFAVLR 8 1 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-2;A0A087WWG1 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 RQS(1)FAVLR;RQS(1)FAVLR;RQS(1)FAVLR 85.963 0.017731 23436500.0 5059.9 6069.3 5875.0 7561.6 5889.400000000001 5605.1 5902.2 5157.6 3087.5299999999997 4714.6 True False 5177.785825148504 5358.703534458977 5077.207269065007 6241.108508811584 5356.7048098580235 5548.7177830236105 5456.9923021115155 5020.803693754117 5239.312905730959 5319.764834092914 0.9733110366017488 1.007319628137792 0.9544044572283681 1.1731925570871162 1.0069439114166048 1.0430381710603822 1.0257957771251744 0.9438018127375036 0.9848767885665997 1.0 12.377146755917352 -10.33877860125442 7.621968707339302 1.0000104804696728 1.0144867271895452 0.002832611338964952 0.0611696850939191 0.0 0.0 0.06046255535417394 0.01466432365411846 4.583755021578091e-11 10.33877860125442 0.014476246719872465 RQS(ph)FAVLR ddPTM_A459_Selumetinib_30min_R2 1 RQSFAVLR 8 1 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-2;A0A087WWG1 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 RQS(1)FAVLR 66.595 0.04196 25581000.0 45875.0 41909.0 50871.0 42230.0 47923.0 36206.0 32471.0 33625.0 27840.0 36035.0 True False 43325.45115217536 45123.285541325735 47598.015244156944 36478.20114918666 41902.48430294423 41193.047854655626 33980.96584006587 33722.843183081604 33408.77791459333 34994.575919826 1.238061899976606 1.2894365585313856 1.360154080826867 1.042395862511942 1.1973994026658454 1.177126648113427 0.9710352232276697 0.9636591470730211 0.9546844628474482 1.0 15.094843704464525 -6.825938797677149 0.7306682621647221 0.9469147811262606 1.2821174026838535 0.7057240490929769 0.07747223015744274 0.3845973197050073 0.44612322823635464 0.05881927507899699 0.054951869106434445 1.4930047942996823e-07 6.825938797677149 0.33520262155759295 RQS(ph)GLYDSQNPPTVNNCAQDR ddPTM_A459_Selumetinib_30min_R2 3 RQSGLYDSQNPPTVNNCAQDR 21 1 H0Y7W6;B7ZL14;Q96RU3-4;Q96RU3-3;Q96RU3-5;Q96RU3-2;Q96RU3 H0Y7W6;Q96RU3-5 FNBP1 Formin-binding protein 1 1 RQS(0.952)GLY(0.048)DSQNPPTVNNCAQDR;RQS(0.999)GLY(0.001)DSQNPPTVNNCAQDR;RQS(0.927)GLY(0.07)DS(0.003)QNPPTVNNCAQDR 158.12 7.5991e-08 15179500.0 18132.199999999997 19764.6 15570.8 18067.9 19805.7 17797.7 17399.0 17081.8 15486.6 18747.0 True False 17124.48491294765 21280.48126679441 14568.991680205207 15607.020851134026 17317.530900795482 20249.17162356528 18208.08797546444 17131.505209955787 18584.352731757936 18205.725399444367 0.9406098651510081 1.1688895004119904 0.8002423062280093 0.8572589396306256 0.9512134518586118 1.112241955719231 1.0001297710455495 0.9409954744499571 1.0207971571583259 1.0 14.152104605052092 -6.556742604547951 24.91101177106374 1.0126152322482802 0.9424127436783788 0.11893429674145894 0.09705432695163682 449.44102233655394 330615.86344676954 0.03380698052494217 0.03380713767212199 2.7749642691326144e-07 6.556742604547951 -0.07020248856990141 RQS(ph)LELQK ddPTM_A459_Selumetinib_30min_R1 1 RQSLELQK 8 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 RQS(1)LELQK 93.561 0.042901 5805300.0 1701.7 2307.3 2565.0 2592.4 2603.4 2170.2 2179.2 1980.7 1399.4 2143.0 True False 1741.3462990682033 2037.1602433653313 2216.6870885364674 2139.68600537494 2367.9229296676026 2148.369758383943 2014.821189516014 1928.165401779663 2374.679591867901 2418.074924587688 0.7201374454371485 0.842471927834367 0.9167156344067544 0.8848716735854589 0.9792595364146389 0.8884628580110133 0.8332335648613395 0.7973968805405974 0.982053768359892 1.0 11.239643232167417 -4.809090551233565 2.4148924344786495 0.9009863934837246 0.6845115512650785 0.4625934213573395 0.06215493006217674 0.492386487486371 3.7533284011670873 0.01644098408510117 0.22082749351452224 1.5520633680262103e-05 4.809090551233565 -0.2164748422186461 RQS(ph)LELQK ddPTM_A459_Selumetinib_30min_R2 2 RQSLELQK 8 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 RQS(1)LELQK;RQS(1)LELQK 113.67 0.0054664 21513000.0 70590.0 63991.0 67255.0 73252.0 64826.0 56712.0 57792.0 64004.0 51609.0 68900.0 True False 66666.89039415921 68898.90393650465 62927.886521707376 63274.9512332518 56681.9783282069 64523.56321972138 60479.44251267547 64190.24104356736 61932.242075942806 66910.67797630116 0.9963565220153906 1.029714628820645 0.9404759961331668 0.9456629815597283 0.8471290389298234 0.9643238593782406 0.9038832715773177 0.9593422602338996 0.9255957935126342 1.0 16.02994884204815 -5.32972217963742 5.243507084121925 0.9308042247673847 1.012904522998351 0.37984607614206334 0.03913359233323749 0.18259915739143473 9.636763817402288 0.009871095360573344 0.021514953838161065 4.680344495319263e-06 5.32972217963742 0.08210029823096643 RQS(ph)PEPSPVTLGR ddPTM_A459_Selumetinib_30min_R1 2 RQSPEPSPVTLGR 13 1 Q9NRL2;Q9NRL2-2 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 RQS(0.903)PEPS(0.093)PVT(0.004)LGR;RQS(1)PEPSPVTLGR 129.76 0.0030401 131959000.0 6271.799999999999 9359.3 8032.1 8444.7 7744.9 8017.700000000001 8175.8 7062.9 3711.3999999999996 6415.0 True False 6417.920737201596 8263.508804979476 6941.384937167153 6969.991671651663 7044.375162473154 7937.04921748914 7559.092823625658 6875.568948467495 6297.9747300689805 7238.427737391516 0.8866456874396315 1.1416165367366595 0.9589630772039168 0.9629151418680062 0.973191336301398 1.096515639230431 1.0443003781854012 0.9498704964546925 0.8700749608282417 1.0 12.821460647467914 -7.911850386368027 5.909110426620859 0.9271199823888998 1.0122190462468292 0.15100256907421228 0.07486158987742927 0.3292845268334957 17.341959319277237 0.04088954682708447 0.01922166328644953 1.2250381499182433e-08 7.911850386368027 0.08509906385792942 RQS(ph)PEPSPVTLGR ddPTM_A459_Selumetinib_30min_R2 5 RQSPEPSPVTLGR 13 1 Q9NRL2;Q9NRL2-2 Q9NRL2 BAZ1A Bromodomain adjacent to zinc finger domain protein 1A 1 RQS(0.999)PEPS(0.001)PVTLGR;RQS(0.982)PEPS(0.018)PVTLGR;RQS(1)PEPSPVTLGR;RQS(0.999)PEPS(0.001)PVTLGR;RQS(1)PEPSPVTLGR 132.51 0.0020438 230352000.0 366928.0 324402.0 429197.0 390882.0 426508.0 337672.0 362329.0 374906.0 343344.0 355225.0 True False 346535.6106891636 349282.5902831644 401582.9322943616 337643.1972909396 372926.25201010227 384183.2529187781 379178.0164412927 375996.91439097055 412022.39383290755 344968.73126460833 1.0045420911594258 1.0125050725691631 1.164114007731116 0.978764643546636 1.0810436373262164 1.1136755830315828 1.0991663361814787 1.0899449147539173 1.1943760593097514 1.0 18.39610607315685 -6.514420745260859 23.075704180789486 1.1041844223391277 1.0447628018639736 0.15967369422573718 0.06369119724295257 270.9690521084363 739282.6577061331 0.019894490535317735 0.02087836290723322 3.05899843459e-07 6.514420745260859 -0.05942162047515409 RQS(ph)PLPPQK ddPTM_A459_Selumetinib_30min_R1 4 RQSPLPPQK 9 1 Q01105;B2REB7 Q01105 SET Protein SET 1 RQS(1)PLPPQK;RQS(1)PLPPQK;RQS(1)PLPPQK;RQS(1)PLPPQK 134.13 0.0046969 137475000.0 41201.5 48361.9 51885.6 53963.0 49966.2 41686.5 44631.100000000006 42285.9 24869.700000000004 34854.9 True False 42161.41478583685 42699.66626516265 44839.820507199845 44539.37506096589 45446.766032249085 41267.17165831364 41264.54019429524 41164.3405680389 42202.064488978955 39328.86593047661 1.0720221340825709 1.0857080481457246 1.1401249297771563 1.1324856185708514 1.1555575010117851 1.0492845568256013 1.049217647598596 1.0466699101064072 1.0730557185040988 1.0 15.263300965523475 -6.785897076362279 23.07628748785563 1.046910580718786 1.1175562677366304 0.622667631918171 0.028564274817668007 70.90882575158659 66902.75852950728 0.010544454581523411 0.009305975780752674 1.6372044772545865e-07 6.785897076362279 0.07064568701784446 RQS(ph)PLPPQK ddPTM_A459_Selumetinib_30min_R2 4 RQSPLPPQK 9 1 Q01105;B2REB7 Q01105 SET Protein SET 1 RQS(1)PLPPQK;RQS(1)PLPPQK;RQS(1)PLPPQK;RQS(1)PLPPQK 137.01 0.0046522 94643000.0 520860.0 522334.0 557660.0 594650.0 595130.0 426656.0 421932.0 465211.0 394570.0 505290.0 True False 491912.68636778323 562395.3382314736 521780.762734299 513657.64417153253 520364.4488702952 485423.9912024511 441552.674042397 466564.68699017307 473495.0252069347 490700.9647989148 1.0024693686293544 1.1461060372317355 1.063337552124277 1.0467834404646528 1.060451244646597 0.9892460500895365 0.8998406478033758 0.9508126546711956 0.9649359980389871 1.0 18.9044845824218 -6.855635857115039 3.210569207148826 0.9490344122661188 1.068557918086919 0.6244030591655947 0.04040553673700372 0.15065956071151268 3.0939480814860754 0.014778791054410921 0.013055336256829336 1.394325412953839e-07 6.855635857115039 0.11952350582080007 RQS(ph)SGSATNVAST(ph)PDNR ddPTM_A459_Selumetinib_30min_R2 1 RQSSGSATNVASTPDNR 17 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 2 RQS(0.944)S(0.014)GS(0.042)AT(0.004)NVAS(0.162)T(0.833)PDNR 137.13 0.00055422 0.0 2662.5 2174.4 3161.8 5231.7 3037.4 3227.3 4826.3 4980.6 4054.0 4648.4 True False 2514.5289088319746 2341.1694882020265 2958.373230307552 4519.133434814112 2655.8146572994756 3671.8312804874954 5050.732513132019 4995.092721417286 4864.913278224184 4514.188614006358 0.5570278789481775 0.5186246496076801 0.6553499384426442 1.0010953952593853 0.5883260280838002 0.8133978427695188 1.118857217764651 1.106531682331307 1.0776938436133612 1.0 12.14025098383135 -6.387633810520233 0.540238006436498 1.111739203393647 0.4978660376024331 0.6657952700156891 0.13411684170267463 0.6837632999812465 0.41398712469102383 0.11451999219116671 0.209301222961447 4.0960588665476857e-07 6.387633810520233 -0.613873165791214 RQS(ph)SGSATNVASTPDNR ddPTM_A459_Selumetinib_30min_R1 1 RQSSGSATNVASTPDNR 17 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RQS(0.991)S(0.009)GSATNVASTPDNR 295.16 4.5231999999999994e-76 17715000.0 1862.2 1964.1 2322.8 2313.9 2287.2 1912.5 2119.7 2392.4 1603.9 1714.6 True False 1905.58563678957 1734.1422589146816 2007.3765182270974 1909.8208022824713 2080.323163837957 1893.2619864110632 1959.8093224197396 2328.945780389592 2721.701155778853 1934.6856116183155 0.9849588095068302 0.8963431828410175 1.0375724645762874 0.9871478811924148 1.0752771154884537 0.9785889630033469 1.0129859397571106 1.2037851351163396 1.4067924728618924 1.0 10.91788343066501 -7.7724590483271 4.634535091915715 1.2344354883940798 0.994607442214741 0.46173134437762875 0.10160928368494097 0.14717969102305523 7.859478391795008 0.05255039928177659 0.02604263240476172 1.6886550832236413e-08 7.7724590483271 -0.23982804617933884 RQS(ph)SGSATNVASTPDNR ddPTM_A459_Selumetinib_30min_R2 2 RQSSGSATNVASTPDNR 17 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RQS(0.973)S(0.026)GS(0.001)ATNVASTPDNR;RQS(0.761)S(0.234)GS(0.005)AT(0.001)NVASTPDNR 128.29 0.00052681 66657000.0 40238.0 36173.0 46400.0 54823.0 57575.0 41526.0 42452.0 60900.0 49101.0 72151.0 True False 38001.73304547644 38947.35278547274 43414.674516500185 47356.01282505 50341.9137729694 47245.82956450396 44426.10211704216 61077.208917462296 58922.5719965678 70067.81315918866 0.5423564876948483 0.5558522669601142 0.6196093835248632 0.675859723457628 0.718474168140462 0.6742872002750404 0.6340443652224379 0.8716871008761126 0.8409363635011737 1.0 16.096464249469747 -7.632383248236159 0.18233087094297498 1.1264995834723206 0.39376174744010645 0.866368826192042 0.051125040308934167 1.3239663799732992 0.22316392598411983 0.3209462444717755 0.40381556190159335 2.3313997832794044e-08 7.632383248236159 -0.7327378360322141 RQS(ph)SSYDDPWK ddPTM_A459_Selumetinib_30min_R1 2 RQSSSYDDPWK 11 1 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;H0YCF0;H7C1V2;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 RQS(0.918)S(0.065)S(0.017)YDDPWK;RQS(0.974)S(0.021)S(0.005)YDDPWK 185.57 3.413e-05 80889000.0 12686.7 12371.3 13673.5 12203.1 13375.3 11842.6 13742.400000000001 13678.4 7694.299999999999 10428.4 True False 12982.275425979076 10922.862444738666 11816.71380315921 10072.057665557373 12165.506476601015 11723.474196220472 12705.79970393029 13315.604398295007 13056.665130562524 11766.986721218029 1.1032795169701057 0.9282633441782294 1.0042259826682318 0.855958955693866 1.0338676132492257 0.996302152281765 1.0797836357730743 1.1316069877332773 1.1096014162248495 1.0 13.522457303245526 -7.16782447745261 2.1751360404099276 1.0939366360562364 0.9760886192369312 0.29695956985782024 0.06890711273273549 0.3479705188775528 3.2243815095392176 0.03136661645730281 0.021829000234470063 6.794781920482256e-08 7.16782447745261 -0.11784801681930512 RQS(ph)SSYDDPWK ddPTM_A459_Selumetinib_30min_R2 1 RQSSSYDDPWK 11 1 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;H0YCF0;H7C1V2;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 RQS(0.586)S(0.202)S(0.202)Y(0.011)DDPWK 67.846 0.037809 18396000.0 92070.0 92430.0 111860.0 108710.0 108260.0 82612.0 83456.0 95057.0 88281.0 104930.0 True False 86953.11798541227 99519.0837907068 104663.0493839591 93903.5104647902 94659.41094332037 93991.0531229303 87336.86936492682 95333.60013246654 105939.66677723489 101900.39825911875 0.8533148002454555 0.9766309601425052 1.027111288788247 0.9215225069680929 0.9289405395905761 0.9223816072232017 0.85708074607168 0.9355566981205142 1.0396393791106178 1.0 16.63680016446196 -8.249292585112205 20.73317153282987 1.0198196354577005 0.9300427870343265 0.36245634957139583 0.04873596550773838 79.40279428447731 135538.07990364905 0.035654580949266386 0.013130134749349704 5.632580598252282e-09 8.249292585112205 -0.08977684842337397 RQS(ph)STPSAPELGQQPDVNISEWK ddPTM_A459_Selumetinib_30min_R1 2 RQSSTPSAPELGQQPDVNISEWK 23 1 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L213 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 RQS(0.614)S(0.358)T(0.026)PS(0.002)APELGQQPDVNISEWK;RQS(0.62)S(0.351)T(0.027)PS(0.002)APELGQQPDVNISEWK 159.38 6.8553e-10 25516000.0 2869.7 3262.5 4491.5 5100.5 3865.5 3271.2 2960.6 3416.7 1684.46 2423.7 True False 2936.558426535833 2880.524983304897 3881.5789700434866 4209.793423242897 3515.8662075094567 3238.2946980119573 2737.2795584072664 3326.07801699428 2858.4055919092516 2734.805503837226 1.0737723111992885 1.0532833063496512 1.4193254198871599 1.5393392390559784 1.285600092063702 1.1841042053880182 1.0009046546697997 1.216202765544912 1.0451952023274056 1.0 11.41722251854749 -6.97352004141706 3.903615242153133 1.0833965676412443 1.2834689500309382 0.3065057006106635 0.14634793685191597 0.32770102131480644 11.023484235318783 0.06175104050380696 0.051824360018871196 1.0628695338311264e-07 6.97352004141706 0.20007238238969394 RQS(ph)STPSAPELGQQPDVNISEWK ddPTM_A459_Selumetinib_30min_R2 2 RQSSTPSAPELGQQPDVNISEWK 23 1 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L213 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 RQS(0.466)S(0.466)T(0.048)PS(0.019)APELGQQPDVNISEWK;RQS(0.485)S(0.485)T(0.023)PS(0.006)APELGQQPDVNISEWK 135.57 2.8283e-06 20547600.0 72239.0 58569.0 75072.0 83922.0 70155.0 51095.0 49792.0 50263.0 35611.0 72301.0 True False 68224.24557562933 63061.05397098254 70241.94925221337 72491.67882647511 61341.50170634254 58132.87245577063 52107.426660976256 50409.257008512395 42734.19505447496 70213.48226944194 0.971668736124225 0.8981331210576882 1.0004054347092797 1.0324467108509254 0.8736427780486166 0.8279445852391658 0.7421285054772773 0.7179426995953359 0.6086323263455854 1.0 16.099460460445236 -6.756201576443963 1.9077276470716613 0.7459678514072953 0.9705048390978298 0.46133832620639603 0.09871827195268332 0.27214337227147617 2.043062307272295 0.0388976815365958 0.0357807384940163 1.753066632509691e-07 6.756201576443963 0.22453698769053454 RQS(ph)VGDFVSGALNK ddPTM_A459_Selumetinib_30min_R1 1 RQSVGDFVSGALNK 14 1 Q6P4F7-3;Q6P4F7;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 RQS(1)VGDFVSGALNK 99.413 0.004985100000000001 14438000.0 4261.9 5341.8 5308.1 6156.7 5151.8 4777.6 5222.4 4531.6 2843.2 4407.8 True False 4361.193977786201 4716.379572664555 4587.289175306206 5081.547920572403 4685.820599624166 4729.541681713726 4828.470163421639 4411.407247288693 4824.702740888109 4973.584065607846 0.8768714714090587 0.9482858860832671 0.922330680409555 1.0217074555371695 0.942141630223252 0.9509322893360415 0.9708230724017184 0.8869674643268652 0.9700655859525434 1.0 12.280070146544292 -1.524884514039011 0.007245860913512772 1.8155211289027255 3.913010116104561e-08 0.1785756798050412 0.039109216548044126 53642.22840031246 30.18086619576066 3395.807654150254 4206.440174630855 0.02986176586235163 1.524884514039011 -1.8155210897726244 RQS(ph)VGDFVSGALNK ddPTM_A459_Selumetinib_30min_R2 1 RQSVGDFVSGALNK 14 1 Q6P4F7-3;Q6P4F7;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 RQS(1)VGDFVSGALNK 115.91 0.0014008 5556400.0 63235.0 60229.0 66351.0 73134.0 68751.0 65956.0 57048.0 65543.0 52805.0 73557.0 True False 59720.65184976145 64848.37063324131 62082.048897506495 63173.02303681306 60113.884738261746 75040.84031104429 59700.84503846748 65733.71927877229 63367.47549497491 71433.21828596218 0.8360347368179204 0.9078181298459725 0.8690921449034958 0.8843647892765824 0.8415396391299806 1.0505034228003005 0.835757459498359 0.9202122045744376 0.8870869465981722 1.0 16.124307500187342 RQS(ph)VSGLHR ddPTM_A459_Selumetinib_30min_R2 2 RQSVSGLHR 9 1 Q8N1G4;J3KRP5 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 1 RQS(0.995)VS(0.005)GLHR;RQS(0.999)VS(0.001)GLHR 77.67399999999998 0.02742 32887000.0 17133.3 17063.7 19613.7 19723.1 22870.0 17700.1 17964.4 17546.300000000003 15582.4 19288.4 True False 16181.099776034129 18372.430921556705 18351.775895781888 17036.779755754767 19996.86613960591 20138.128109489866 18799.7801957833 17597.356828053675 18699.31540863358 18731.493774718252 0.8638446015380594 0.9808310614476369 0.9797283717196721 0.9095259545583692 1.06755320104772 1.0750946161416202 1.0036455406005693 0.9394529363058427 0.9982821249350599 1.0 14.193178333879283 -3.599742079171781 0.8991995111781313 1.0026107469561212 1.788106231028372e-12 0.4120909606415597 0.04731125103692722 17.124150998942042 2.0910962544160445 0.01729942439220481 27.441476630547033 0.00025133786453720194 3.599742079171781 -1.002610746954333 RQSSGS(ph)ATNVASTPDNR ddPTM_A459_Selumetinib_30min_R1 2 RQSSGSATNVASTPDNR 17 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RQS(0.012)S(0.204)GS(0.777)AT(0.007)NVASTPDNR;RQS(0.057)S(0.194)GS(0.474)AT(0.275)NVASTPDNR 187.75 7.2009e-14 2037500.0 972.59 933.72 1469.09 1351.6799999999998 1480.03 1138.6100000000001 1352.1799999999998 1029.33 572.95 888.6300000000001 True False 995.2494546692977 824.399628325349 1269.595647133738 1115.6344621760536 1346.161547820519 1127.1566171751645 1250.1839739536367 1002.0288246649463 972.2543033876758 1002.6943164892002 0.992575143094488 0.822184403330293 1.2661841463099712 1.1126366668580492 1.3425443085525042 1.124127860943455 1.2468246337836923 0.9993362964032907 0.9696417815470362 1.0 9.96966613457867 -5.255819891646257 24.99054612494241 1.1431913167153462 0.9073797671410023 0.3446224096169599 0.12358790786980278 482.3239113462744 2144937.2717831065 0.03208285458778709 0.0799840028709291 5.548557721565132e-06 5.255819891646257 -0.23581154957434391 RQSSGS(ph)ATNVASTPDNR ddPTM_A459_Selumetinib_30min_R2 2 RQSSGSATNVASTPDNR 17 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RQS(0.063)S(0.063)GS(0.522)AT(0.345)NVAS(0.003)T(0.003)PDNR;RQS(0.121)S(0.088)GS(0.76)AT(0.031)NVASTPDNR 65.365 0.022387 4883890.0 15458.4 15475.3 18917.0 18165.8 16214.0 9582.7 12497.3 14534.0 9686.4 12277.4 True False 14599.2840128782 16662.205749067707 17699.90081527228 15691.5867022471 14177.05236500088 10902.629941910427 13078.449212930147 14576.291533766765 11623.95066062919 11922.919561483888 1.2244722391686773 1.3974937651088188 1.4845274032083975 1.3160859319170124 1.1890587948608495 0.9144261928203029 1.096916669234196 1.2225438122433032 0.9749248580171174 1.0 13.54144993088075 -6.371906987303589 2.952778811364568 1.058932052645787 1.3716123396368738 0.6834312719354778 0.09974464402716715 0.16201545377741272 2.7181863645963977 0.03371779103418839 0.039214057443564224 4.247105143080042e-07 6.371906987303589 0.31268028699108674 RQSSGSATNVAST(ph)PDNR ddPTM_A459_Selumetinib_30min_R1 1 RQSSGSATNVASTPDNR 17 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RQSSGSATNVAS(0.249)T(0.751)PDNR 118.02 0.0019476 654490.0 284.53 332.14 435.29 436.17 432.8 491.65 315.98 299.52 181.76 267.04 True False 291.1589954009965 293.2528943923032 376.1800088768183 360.00109742492987 393.65331641704597 486.7044473824831 292.14537420304265 291.5757566219237 308.43344477483913 301.317185189872 0.9662873865542237 0.9732365387905532 1.2484518884635545 1.1947579332326457 1.306441636141627 1.6152561861872936 0.9695609429609869 0.9676705178239009 1.0236171713222493 1.0 8.235139147078742 RQVDQLTNDK ddPTM_A459_Selumetinib_30min_R1 3 RQVDQLTNDK 10 1 P08670;B0YJC4 P08670 VIM Vimentin 0 ;; 169.82 1.6492e-05 15107000.0 8135.5 8305.7 8657.9 9593.3 8993.7 8699.400000000001 7886.6 7342.5 4959.5 6944.0 False True 8325.041321072678 7333.264782784825 7482.2047344405 7918.010243543979 8180.2214229667 8611.891934423218 7291.707412461911 7147.753048198698 8415.909272451665 7835.330040287865 1.0625004024421187 0.9359228960463043 0.954931661585197 1.010552229814314 1.0440174671526872 1.099110297861406 0.9306190517781965 0.912246582013295 1.0740976103340338 1.0 12.935778329935347 -3.3895912359161473 15.859122174936578 0.9988720773173604 0.9963569863538368 0.0 0.06323508624040224 0.0 0.0 0.014837730806420615 0.0 0.00040776389036240507 3.3895912359161473 -0.0025150909635235363 RQVDQLTNDK ddPTM_A459_Selumetinib_30min_R2 4 RQVDQLTNDK 10 1 P08670;B0YJC4 P08670 VIM Vimentin 0 ;;; 164.48 0.00050693 44437800.0 163106.0 136939.0 151816.0 153398.0 148225.0 111538.0 149412.0 125106.0 104611.0 135869.0 False True 154041.22148505086 147441.780971715 142048.32384476296 132504.92777369023 129603.65035168716 126901.3470588461 156359.95405426127 125470.03774758676 125536.12307555774 131946.1089399427 1.1674555826058128 1.1174394012545332 1.0765631892140028 1.0042352051018184 0.9822468536050446 0.9617664975373181 1.185028913019564 0.9509188164441922 0.951419667348413 1.0 17.009589280987164 -5.362324357586464 1.7007808828151476 1.0074230768498649 1.16065166947104 0.4287785595789969 0.06445453777900427 0.44296911326819405 2.2982871378639627 0.01971794729886403 0.07516253546535225 4.341858266106472e-06 5.362324357586464 0.15322859262117516 RQVEEAER ddPTM_A459_Selumetinib_30min_R2 1 RQVEEAER 8 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 105.1 0.019344 1373200.0 3001.3 2663.2 1132.5 1093.4 2046.4 2273.4 4389.2 11405.0 3979.6 7056.3 False True 2834.499761155832 2867.4588764623063 1059.6361829727693 944.4770337797943 1789.3129369518824 2586.54021412954 4593.306497034803 11438.18666180061 4775.631199314499 6852.566284530821 0.41364061921655726 0.4184503669720627 0.15463348167311017 0.13782822296982136 0.2611157430160331 0.37745570151849095 0.6703045700417177 1.6691829289738502 0.6969113469351104 1.0 12.74242866289758 -7.4956230148558305 4.011712976227049 1.1481367605524033 0.2923098835182483 0.6953206949624391 0.24421378404494698 0.11164987363463769 4.000474722949058 0.11010130946198718 0.06680769129733234 3.1943094415621703e-08 7.4956230148558305 -0.855826877034155 RRAPS(ph)VANVGSHCDLSLK ddPTM_A459_Selumetinib_30min_R1 1 RRAPSVANVGSHCDLSLK 18 2 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 RRAPS(0.999)VANVGSHCDLSLK 56.121 0.02546 10811000.0 3006.9 2172.0 1815.0 2133.0 1789.1 1812.3 1978.2 2355.8 1219.4 2026.3 True False 3076.954919591104 1917.7012302645946 1568.5329690813585 1760.5115913689062 1627.2762208912602 1794.069907436743 1828.9827813420418 2293.3165312831466 2069.2327385477483 2286.3953428334266 1.3457667892981153 0.838744373878961 0.6860287631348769 0.7699943917779257 0.7117212803953012 0.7846717817459482 0.7999416142422097 1.003027117979143 0.905019661203229 1.0 11.158859167580934 -10.017087733502276 11.573556227634015 0.9999989880248771 0.8567308849410759 0.03746838067997016 0.18147225096725958 0.0 0.0 0.17950101918283246 0.043535391882167075 9.614180390009608e-11 10.017087733502276 -0.14326810308380122 RRAPS(ph)VANVGSHCDLSLK ddPTM_A459_Selumetinib_30min_R2 1 RRAPSVANVGSHCDLSLK 18 2 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 1 RRAPS(0.982)VANVGS(0.018)HCDLSLK 46.663 0.045443 5229600.0 34181.0 25126.0 36241.0 36471.0 25097.0 24571.0 27395.0 23927.0 15612.0 33417.0 True False 32281.35685738432 27053.083407176277 33909.29351621733 31503.58688401579 21944.090489973296 27955.432216669727 28668.92178216267 23996.623608671907 18734.836235726696 32452.16438220688 0.9947366368908136 0.8336295566778636 1.044900830553212 0.9707699774036894 0.6761980566696799 0.8614350613852229 0.883420946736036 0.739446014325903 0.5773062164691479 1.0 14.986027080866185 -6.239101168659103 24.25853706899759 0.784886043928657 0.957902989397126 0.32908998375317244 0.11972675233750073 667.6029086102749 724993.2994310394 0.03513891737863318 0.045323423549257884 5.766321216119712e-07 6.239101168659103 0.17301694546846902 RRAS(ph)QEANLLTLAQK ddPTM_A459_Selumetinib_30min_R1 1 RRASQEANLLTLAQK 15 2 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2;H7C1L3 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 RRAS(1)QEANLLTLAQK 79.92 0.034099000000000004 18821000.0 2375.2 2435.0 4410.5 4146.2 2845.4 2849.4 2846.8 2831.1 1600.1 2062.9 True False 2430.5375386653322 2149.9090679992123 3811.5783251423336 3422.1440038132946 2588.0340723961726 2820.7376230482 2632.063584028171 2756.010031291161 2715.252833319871 2327.693309347617 1.044182895102508 0.9236221367160126 1.637491635962388 1.4701868111535792 1.1118449591288817 1.2118166992707338 1.130760471518415 1.1840090875475293 1.1664993933762158 1.0 11.184685269785112 RRDEDMLYS(ph)PELAQR ddPTM_A459_Selumetinib_30min_R1 2 RRDEDMLYSPELAQR 15 2 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 1 RRDEDMLYS(1)PELAQR;RRDEDMLY(0.018)S(0.982)PELAQR 127.49 0.00041156 64635000.0 11486.5 14307.0 16290.8 17055.2 15484.9 13807.5 13478.2 12338.1 7511.6 11349.0 True False 11754.11310116174 12631.929788856143 14078.598838959017 14076.829485754783 14084.293529081147 13668.609086206934 12461.52852263892 12010.853508202987 12746.636574442566 12805.754698621398 0.9178774213461334 0.9864260315884413 1.0993962613132553 1.0992580927128193 1.099840959049246 1.0673802058443635 0.9731194151314225 0.9379262519760755 0.9953834720740671 1.0 13.6445046592614 -7.271050082525315 22.688544313139243 0.9714344444476759 1.0497935566317698 0.2577647905667555 0.05626161902977981 277.3069121165355 654646.4930566759 0.02579001542165658 0.017691244136965465 5.357348733931197e-08 7.271050082525315 0.07835911218409386 RRDEDMLYS(ph)PELAQR ddPTM_A459_Selumetinib_30min_R2 4 RRDEDMLYSPELAQR 15 2 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 1 RRDEDMLY(0.014)S(0.986)PELAQR;RRDEDMLY(0.004)S(0.996)PELAQR;RRDEDMLY(0.004)S(0.996)PELAQR;RRDEDMLYS(1)PELAQR 97.214 0.0037854 118804000.0 140401.0 147410.0 180397.0 180672.0 159187.0 114886.0 102515.0 111791.0 111851.0 151713.0 True False 132598.0744897344 158715.87300214323 168790.4534214027 156064.16192341584 139188.50591016372 130710.50366872808 107282.15062961869 112116.29330200382 134224.32537805988 147332.6514922867 0.8999910959769586 1.07726204201553 1.1456418635772625 1.0592639197264855 0.9447227379699377 0.887179470027872 0.7281627632638866 0.7609738382253538 0.9110290490162455 1.0 17.1687176666968 -6.59597005312246 2.253633352974897 0.8306240797329313 1.0538852414150275 0.47053972116863674 0.09235895944457485 0.23970782181326092 2.4739030280163963 0.03445017256137314 0.03533823087070262 2.5353034469125363e-07 6.59597005312246 0.2232611616820962 RRDEQLS(ph)PEEEEK ddPTM_A459_Selumetinib_30min_R1 1 RRDEQLSPEEEEK 13 2 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 RRDEQLS(1)PEEEEK 96.773 0.015724000000000002 7207100.0 1708.8 2148.3 2054.2 2002.8 1958.2 2107.5 1825.0 1860.6 1098.8 1922.2 True False 1748.6117152540082 1896.7760372824264 1775.250922912909 1653.0485772122104 1781.0811557482891 2086.300463456897 1687.3387806840697 1811.2508439194419 1864.5833468232458 2168.9330938135568 0.8062082321679583 0.8745203080226848 0.8184904034045372 0.7621482570980163 0.8211784682655556 0.9619017153676374 0.777957967212941 0.8350883893494312 0.8596776692382042 1.0 11.08276983480821 -6.5635739534365 24.999628658193608 0.8722224503048835 0.8162771542421863 0.21573743557086034 0.06420285018248412 294.8786085077435 181146.15056072854 0.02098158943770649 0.020981615021804952 2.731656246699668e-07 6.5635739534365 -0.05594529606269727 RRDEQLS(ph)PEEEEK ddPTM_A459_Selumetinib_30min_R2 2 RRDEQLSPEEEEK 13 2 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 RRDEQLS(1)PEEEEK;RRDEQLS(1)PEEEEK 106.82 0.0077188 14039800.0 41309.0 35204.0 43073.0 49618.0 44016.0 34999.0 47704.0 40997.0 34244.0 45912.0 True False 39013.211153029115 37904.03360129882 40301.73007433649 42859.94280417579 38486.31657196735 39819.79456071074 49922.33052368274 41116.29448258131 41093.75685730367 44586.40126629806 0.8750024681296357 0.8501254311805088 0.903901838446866 0.9612783626153012 0.8631850851137959 0.8930928137232215 1.1196761592288005 0.9221711848195353 0.9216657027748412 1.0 15.4443161386364 -7.071799578384411 24.99999668079103 0.9875343858024042 0.891601021025732 0.41201527942747795 0.05834150813823045 164.26672594416345 57195.355100589775 0.0226662903454544 0.017557238491535006 8.476184895080136e-08 7.071799578384411 -0.09593336477667214 RRDS(ph)DGVDGFEAEGK ddPTM_A459_Selumetinib_30min_R2 1 RRDSDGVDGFEAEGK 15 2 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 1 RRDS(1)DGVDGFEAEGK 50.252 0.048133 11855000.0 99883.0 94876.0 96803.0 103700.0 99903.0 79627.0 89967.0 92086.0 77344.0 93577.0 True False 94331.90272332935 102152.68412557754 90574.80037113735 89575.88110752223 87352.29199584825 90594.8964680624 94150.64376622855 92353.95501434206 92814.96117192176 90875.18886775526 1.038038037649687 1.124098727037956 0.9966944938397316 0.9857022826976037 0.9612336775769055 0.9969156333738052 1.0360434452933005 1.0162724959916039 1.0213454555455102 1.0 16.471598836967274 -5.279745821245722 24.88506676966834 1.0013853522588556 1.081068381549519 0.5752646297969916 0.027251524947543283 469.8740977550645 638727.8569682156 0.0073923083843435294 0.015430746296763881 5.251147032739366e-06 5.279745821245722 0.0796830292906634 RRDS(ph)GDNSAPSGQER ddPTM_A459_Selumetinib_30min_R2 1 RRDSGDNSAPSGQER 15 2 Q8IXQ3 Q8IXQ3 C9orf40 Uncharacterized protein C9orf40 1 RRDS(1)GDNSAPSGQER 86.179 0.022556 9020300.0 7199.1 6460.3 7839.4 7788.8 7080.5 3913.2 7010.8 6394.4 5654.0 9715.8 True False 6799.002842280662 6955.7842368614565 7335.021538893355 6727.952003570566 6190.984289526877 4452.207779507222 7336.816091636649 6413.006645350097 6784.957985959436 9435.279609319978 0.7205936785980084 0.7372101861179264 0.7774037275639367 0.7130633412204161 0.656152710451903 0.47186813362790236 0.7775939235960205 0.6796837943218407 0.7191051316865472 1.0 13.203849556595081 -9.157411920144817 1.5762017904763406 1.000056929188752 0.6904689073102147 0.5545554577812388 0.08237970829417651 4.565293717250955 10.497232568327162 0.08404145872788539 0.02397282135983505 6.959660902185194e-10 9.157411920144817 -0.3095880218785373 RREDS(ph)YHVR ddPTM_A459_Selumetinib_30min_R2 2 RREDSYHVR 9 2 B1AVT0;P49760-2;P49760-3;P49760 B1AVT0 CLK2 Dual specificity protein kinase CLK2 1 RREDS(0.999)Y(0.001)HVR;RREDS(1)YHVR 85.522 0.013722 12723600.0 10934.4 16794.1 14079.7 15277.3 18225.4 11527.7 11069.7 12848.5 11939.6 15818.099999999999 True False 10326.709821871304 18082.153468457356 13173.827430818274 13196.505385187527 15935.762314856738 13115.536036958354 11584.462984194426 12885.887007816315 14327.853620297357 15361.39035264048 0.6722509867146393 1.1771169831218569 0.8575934292662393 0.85906972495619 1.0373906234416814 0.8537987601300631 0.7541285468475297 0.8388490046801884 0.9327185424875641 1.0 13.907021179207623 RREEEGLQLR ddPTM_A459_Selumetinib_30min_R2 2 RREEEGLQLR 10 2 C9J352;C9JWD9;F2Z3G4;C9J4U1;C9JYI4;P52294 C9J352 KPNA1 Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 ; 126.31 0.0022057 5384500.0 14604.8 17505.9 21928.9 18138.800000000003 20385.0 16207.3 14535.900000000001 15357.7 10082.099999999999 18208.3 False True 13793.123683646658 18848.546239659616 20518.018448381055 15668.26414882471 17824.05405578778 18439.708459779053 15211.848152339413 15402.388364395902 12098.801717410972 17682.579068155064 0.7800402662124661 1.0659387506206246 1.1603521392041953 0.8860847780424759 1.0080008118209125 1.0428178145679845 0.8602731588931366 0.8710487483205656 0.6842215533592587 1.0 14.110041091918925 -7.349461811134907 5.345216113053308 0.8399480562572712 0.9975081541466317 0.2337280055196167 0.12004651656805469 0.311023909099713 14.458094809995384 0.05068196151944408 0.03376445361714812 4.472374770426572e-08 7.349461811134907 0.15756009788936054 RREEEMMIR ddPTM_A459_Selumetinib_30min_R1 2 RREEEMMIR 9 2 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 ; 104.01 0.0093399 28265000.0 5004.799999999999 6431.1 6896.9 6555.799999999999 7461.1 4730.5 5291.3 5055.799999999999 3233.3 4270.9 False True 5121.4021023544365 5678.143822262722 5960.338861959901 5410.952597607251 6786.244822364196 4682.915464950346 4892.172980949933 4921.703760447119 5486.673949111396 4819.111617088919 1.0627274297182854 1.1782553037633767 1.2368127853324888 1.1228112207278247 1.4081941572591263 0.9717383279408571 1.0151607536131624 1.021288600785755 1.1385239407311614 1.0 12.234551500879192 -6.813325909448333 24.999998100625376 1.0297863816795647 1.198018394050773 0.46218977385147497 0.09294966783593761 94.85109617713543 45700.482881163596 0.03215855874125179 0.02836121746505916 1.5370007893972998e-07 6.813325909448333 0.16823201237120822 RREEEMMIR ddPTM_A459_Selumetinib_30min_R2 1 RREEEMMIR 9 2 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 74.165 0.039517 11817000.0 10645.0 11337.0 12416.0 9209.1 11399.0 7117.1 8049.4 6879.1 6605.0 10128.0 False True 10053.393515311314 12206.51144579948 11617.168077518669 7954.804693416407 9966.95571164704 8097.415922398771 8423.713049583506 6899.117042103685 7926.184559119575 9835.578324295762 1.0221456414492178 1.2410568085912201 1.1811372645797593 0.8087785416508265 1.0133573627314574 0.8232780681941806 0.8564532528580777 0.7014449801148495 0.8058686838516024 1.0 13.263794168997475 -5.759349652165129 24.99949551852634 0.8509198305464071 1.1574076606065629 0.6338305645350735 0.10070247769611558 33.05028979039826 395370.3702239045 0.028104422918397518 0.04576470557268153 1.7404051023103427e-06 5.759349652165129 0.3064878300601558 RREEGPPPPSPDGAS(ph)SDAEPEPPSGR ddPTM_A459_Selumetinib_30min_R1 3 RREEGPPPPSPDGASSDAEPEPPSGR 26 2 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 RREEGPPPPS(0.022)PDGAS(0.489)S(0.489)DAEPEPPSGR;RREEGPPPPS(0.063)PDGAS(0.468)S(0.468)DAEPEPPS(0.002)GR;RREEGPPPPSPDGAS(0.5)S(0.5)DAEPEPPSGR 85.366 0.00010196 221147000.0 6050.8 7743.9 8672.5 9868.0 8083.3 7191.400000000001 7410.299999999999 7385.799999999999 4381.7 5911.1 True False 6191.771867192739 6837.24058795856 7494.822134632559 8144.739045301618 7352.166942222527 7119.061045268768 6851.335104933245 7189.904591540477 7435.424873293974 6669.8472639898655 0.928322886885547 1.0250970250656926 1.1236872207099384 1.221128269199598 1.1022991458764682 1.067349935238275 1.0272101944407666 1.0779713997887737 1.1147818801545006 1.0 12.703438009489139 -4.921313529607801 3.040143891578856 1.0959198604936302 0.9238446296677807 0.442012817870284 0.05671492255403093 0.28398106024633124 4.619122810394091 0.015713028965547653 0.10108773717831844 1.1986336627982547e-05 4.921313529607801 -0.17207523082584952 RREEGPPPPSPDGAS(ph)SDAEPEPPSGR ddPTM_A459_Selumetinib_30min_R2 4 RREEGPPPPSPDGASSDAEPEPPSGR 26 2 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 RREEGPPPPS(0.249)PDGAS(0.375)S(0.375)DAEPEPPS(0.001)GR;RREEGPPPPS(0.001)PDGAS(0.499)S(0.499)DAEPEPPS(0.002)GR;RREEGPPPPS(0.004)PDGAS(0.49)S(0.49)DAEPEPPS(0.015)GR;RREEGPPPPSPDGAS(0.499)S(0.499)DAEPEPPS(0.002)GR 73.685 0.0011709 71247000.0 18640.8 16506.600000000002 19289.1 22586.1 20444.7 16240.699999999999 14191.699999999999 14559.8 13240.7 16913.600000000002 True False 17604.81896103478 17772.603142915552 18048.060306384144 19509.834216804273 17876.254008062995 18477.709006604044 14851.642170320056 14602.166607495363 15889.209976068825 16425.26042118966 1.071813688769489 1.0820286976995341 1.0987990353626884 1.1877945138474217 1.0883391526018946 1.1249568367735947 0.9041952327988946 0.8890067026674117 0.9673642650786044 1.0 14.00362862409282 -7.259173937159177 24.99920214127715 0.9308921037025402 1.1099162398479574 0.7937362433169283 0.04205135111330117 85.18788162876716 940056.1241572261 0.01682405755551506 0.012409778640121922 5.5058713927853147e-08 7.259173937159177 0.17902413614541723 RREEGPPPPSPDGASS(ph)DAEPEPPSGR ddPTM_A459_Selumetinib_30min_R1 3 RREEGPPPPSPDGASSDAEPEPPSGR 26 2 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 RREEGPPPPSPDGAS(0.257)S(0.741)DAEPEPPS(0.002)GR;RREEGPPPPSPDGAS(0.243)S(0.747)DAEPEPPS(0.009)GR;RREEGPPPPS(0.003)PDGAS(0.289)S(0.675)DAEPEPPS(0.033)GR 160.1 5.2823e-14 135351000.0 2611.17 3162.6800000000003 3376.4 4109.139999999999 3232.0600000000004 2734.76 2913.97 3000.8900000000003 1743.11 2258.09 True False 2672.005180547643 2792.391955309957 2917.9034252376323 3391.5558371109346 2939.720743666541 2707.2507973634097 2694.1668968492936 2921.2966489355126 2957.930358282733 2547.937847159221 1.0486932338348631 1.095941943177023 1.1452019634195152 1.3310983393461857 1.153764699144499 1.0625262309211396 1.0573911368572464 1.1465337163512688 1.1609115040151494 1.0 11.315114370463204 -6.6830361021705205 7.780596535683997 1.0930060381941435 1.1613631305593664 0.15265768825426373 0.08024922707339344 0.5419964295794385 46.542096947584845 0.02869023379724226 0.02862394996972252 2.0747410405497104e-07 6.6830361021705205 0.0683570923652228 RREEGPPPPSPDGASS(ph)DAEPEPPSGR ddPTM_A459_Selumetinib_30min_R2 2 RREEGPPPPSPDGASSDAEPEPPSGR 26 2 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64;E9PD53;F8WCB7 C9JR83 SMC4 Structural maintenance of chromosomes protein 4;Structural maintenance of chromosomes protein 1 RREEGPPPPS(0.007)PDGAS(0.227)S(0.766)DAEPEPPSGR;RREEGPPPPS(0.192)PDGAS(0.078)S(0.715)DAEPEPPS(0.016)GR 51.577 0.009982 69448000.0 27963.6 26272.6 32576.0 37319.5 36184.6 31366.2 28999.4 25715.3 23355.5 34126.1 True False 26409.495059160115 28287.623940276208 30480.09562606704 32236.519720271666 31638.767053571675 35686.60933598573 30347.929561220953 25790.12726560292 28027.252607194117 33140.790822743824 0.7968878956574518 0.8535591106312107 0.9197153981355567 0.972714256961799 0.9546774916384512 1.0768182789257632 0.9157273803011909 0.7781989091190818 0.845702589207968 1.0 15.016320408857096 -5.073251951986648 2.3525286223122666 0.932415800549557 0.7964717812575781 0.2543461484741002 0.07696928771680096 0.5701530520908411 5.493907316101154 0.02333658351399799 0.12208743899533114 8.447886065574185e-06 5.073251951986648 -0.13594401929197886 RREPES(ph)PPASAPIPLFGADTIGQR ddPTM_A459_Selumetinib_30min_R2 3 RREPESPPASAPIPLFGADTIGQR 24 2 Q96AY4 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 RREPES(0.922)PPAS(0.078)APIPLFGADTIGQR;RREPES(0.802)PPAS(0.198)APIPLFGADTIGQR;RREPES(0.977)PPAS(0.023)APIPLFGADTIGQR 65.365 0.0011154 14625900.0 55104.0 49585.3 59729.4 64614.1 67475.0 45329.3 44124.9 45789.1 41614.9 57097.1 True False 52041.54027878952 53388.33306813095 55886.475432453604 55813.548114460355 58998.18726584647 51572.99961658406 46176.79528183061 45922.338700206405 49939.04281745728 55448.55836691822 0.9385553350984612 0.9628443847871716 1.0078977177844295 1.0065824930041805 1.064016612937696 0.9301053288944225 0.8327862191883542 0.8281971624280251 0.900637352679163 1.0 15.758862331118852 -6.9959107443694055 21.889736803908477 0.8768536053690891 0.9955568844931956 0.4537644742078023 0.0541479122729079 20.129153159766396 107745.93038388813 0.019102271508692262 0.016740544936635206 1.0094603277179676e-07 6.9959107443694055 0.1187032791241065 RRFSDS(ph)EGEETVPEPR ddPTM_A459_Selumetinib_30min_R1 1 RRFSDSEGEETVPEPR 16 2 A0A1B0GWH8;H3BQ48;A0A1B0GWD3;A0A1B0GV71;A0A1B0GW34;A0A0D9SFH9;H3BPL0;Q9UBD8;A0A1B0GV41;H3BR84;O95090;H3BR00;Q9UP10;Q9UBH5;A0A0D9SF04;Q13286-5;Q13286-4;Q13286-6;Q13286-2;Q13286-7;Q13286-3;Q13286 A0A1B0GWH8 CLN3 Battenin 1 RRFS(0.416)DS(0.569)EGEET(0.015)VPEPR 76.57300000000002 0.0329 5358000.0 1696.0 1679.4 2045.5 2128.8 1884.0 1665.0 1888.5 1471.7 941.47 1427.5 True False 1735.5135001584727 1482.7750672681207 1767.7323351272296 1757.045042525141 1713.5925326472168 1648.2516116990437 1746.0489245599272 1432.665735244676 1597.6058277518034 1610.7335300274963 1.0774677920368656 0.9205588880010518 1.0974703774230448 1.090835330469061 1.0638584847848573 1.0232925440317289 1.0840085538730426 0.8894492531115432 0.9918498609292198 1.0 10.653502127741074 -7.749516612870314 24.99985409481509 0.9554871531969722 1.0487881382052133 0.35470330012968376 0.055843955365165336 228.24723020827122 478594.9053943492 0.026397616058024057 0.015087709244929762 1.780259808078285e-08 7.749516612870314 0.09330098500824113 RRGNDPLT(ph)SSPGR ddPTM_A459_Selumetinib_30min_R1 1 RRGNDPLTSSPGR 13 2 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RRGNDPLT(0.968)S(0.032)S(0.001)PGR 137.93 0.019784 1699800.0 1010.1 868.09 2387.0 2792.3 1381.5 1125.8 1099.1 1199.2 610.8 510.77 True False 1033.6333646875435 766.453619235908 2062.858510852455 2304.677222962679 1256.5435689236358 1114.475474144615 1016.1940021095135 1167.3933204494226 1036.482988933053 576.3323048211166 1.793467685293756 1.3298814118597806 3.5792866261292255 3.9988687146003556 2.180241430876662 1.9337376454900068 1.763208471239387 2.025555934803552 1.7984120970882573 1.0 9.170757078315923 -6.516304101800994 21.208841376386165 1.8036364229317816 2.6995490196966134 0.25837397457545774 0.7663426439699907 68.80634903202174 221965.23081441707 0.273068637952047 0.2841117695952238 3.0457615387940047e-07 6.516304101800994 0.8959125967648318 RRGPPRNY(ph)QQNYQNS(ph)ESGEK ddPTM_A459_Selumetinib_30min_R2 1 RRGPPRNYQQNYQNSESGEK 20 3 H0Y449;P67809;C9J5V9 H0Y449 YBX1 Nuclease-sensitive element-binding protein 1 2 RRGPPRNY(1)QQNY(0.411)QNS(0.476)ES(0.114)GEK 45.221 0.04786 3597400.0 2017.2 4230.9 21704.0 16964.0 37282.0 18892.0 4219.0 5536.8 16646.0 21559.0 True False 1905.0920994914036 4555.396425512305 20307.588269528456 14653.47393546774 32598.30185469117 21494.201515498946 4415.1918597899 5552.911171333419 19975.6651281006 20936.535652990933 0.09099366442791827 0.21758119399574752 0.9699593383601347 0.6998996480764184 1.5570055330540928 1.0266360142743265 0.2108845480918501 0.26522588375503975 0.9541055626004169 1.0 14.35373512030271 -5.191740694036696 5.55773499726193 0.8142680146968809 0.13313372267502188 0.35277549144573106 0.36871071594678323 0.2746424208038269 15.901859836638307 0.10448602030300728 0.28707161324093283 6.430715640535324e-06 5.191740694036696 -0.681134292021859 RRHES(ph)EEGDSHR ddPTM_A459_Selumetinib_30min_R2 1 RRHESEEGDSHR 12 2 Q6UN15;Q6UN15-5;Q6UN15-3;H0Y8P7 Q6UN15;H0Y8P7 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 1 RRHES(1)EEGDSHR 94.532 0.007384799999999999 1428500.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 RRPESAPAES(ph)SPSK ddPTM_A459_Selumetinib_30min_R1 2 RRPESAPAESSPSK 14 2 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 RRPES(0.014)APAES(0.733)S(0.23)PS(0.023)K;RRPES(0.001)APAES(0.768)S(0.211)PS(0.02)K 102.69 0.008378299999999998 10476800.0 2453.3 3036.5 3351.7 4042.0 3069.0 2891.8 2795.8 2583.32 1628.92 2426.3999999999996 True False 2510.4571167091867 2680.985168369449 2896.5575495702424 3336.1405777370446 2791.409491875959 2862.7111175443215 2584.9105550885056 2514.80196179403 2764.1582683903525 2737.852075137456 0.9169440305072536 0.979229372074402 1.0579671472662813 1.2185247727708413 1.01956183726099 1.0456047437846316 0.9441381360819971 0.9185309844279197 1.0096083325654386 1.0 11.418828785227678 -7.25404160452182 23.425475678832324 0.9612802786693231 1.044944501229594 0.1716908009195539 0.0758967645071654 415.7620877952939 1316538.9721121234 0.0319101089242146 0.024164521843437484 5.571323742350753e-08 7.25404160452182 0.08366422256027084 RRPGASPTGETPTIEEGEEDEDEAS(ph)EAEGAR ddPTM_A459_Selumetinib_30min_R1 1 RRPGASPTGETPTIEEGEEDEDEASEAEGAR 31 2 P04920-2;P04920-3;P04920;C9J9M9;C9J722;C9J035 P04920-2 SLC4A2 Anion exchange protein 2 1 RRPGASPTGETPTIEEGEEDEDEAS(1)EAEGAR 75.558 3.4885e-05 6017200.0 199.43 176.93 301.0 202.79 195.18 214.88 190.0 276.86 61.46 0.0 True False 204.0763309767714 156.21495334747456 260.12585327464956 167.37653333975635 177.5260034618278 212.71850229542972 175.6681470301224 269.51677343197713 104.29313113920337 0.0 0.0 RRPSALEADS(ph)PMAPK ddPTM_A459_Selumetinib_30min_R2 2 RRPSALEADSPMAPK 15 2 A0A494BYR6;Q86Y91-6;Q86Y91 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 1 RRPSALEADS(1)PMAPK;RRPSALEADS(1)PMAPK 89.669 0.01849 6636800.0 33200.0 27955.0 33967.0 36207.0 32430.0 31975.0 27029.0 25853.0 24858.0 35670.0 True False 31354.876910130155 30099.05861050757 31781.60020047334 31275.544139441194 28355.853472121547 36379.26600984961 28285.902056947423 25928.227949805452 29830.294590551777 34640.114418209894 0.9051608932806317 0.8689075979115374 0.9174796542752217 0.9028706938392794 0.8185842901608666 1.0502062888893193 0.8165649141758569 0.7485029534479625 0.8611488469815893 1.0 15.080156074923307 RRS(ph)LEPAENVHGAGGGAFPASQTPSKPASADGHR ddPTM_A459_Selumetinib_30min_R2 3 RRSLEPAENVHGAGGGAFPASQTPSKPASADGHR 34 3 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 RRS(0.999)LEPAENVHGAGGGAFPASQTPSKPASADGHR;RRS(0.926)LEPAENVHGAGGGAFPAS(0.034)QT(0.039)PS(0.001)KPASADGHR;RRS(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR 59.819 0.00034374 17322200.0 32662.800000000003 24077.3 46235.7 49052.0 56414.0 32356.4 27730.1 37047.0 28142.100000000002 49550.7 True False 30847.5323355482 25923.951489278275 43260.94539962389 42371.03298058027 49326.7689724411 36813.20039784509 29019.60459615071 37154.80063653901 33771.3063559726 48120.0425428201 0.6410537211827736 0.5387350076885238 0.8990213456508835 0.8805277539577399 1.0250774181786557 0.7650284258391188 0.603066894014637 0.7721273438916111 0.701813726077255 1.0 15.554350297547405 -14.228864067084025 0.024114257829732456 1.9497649328598399 4.08325396009923e-06 0.1515965575348266 0.1450192697189449 5763.130200301136 10.957751068667339 624.63277489278 311.22574627539024 5.903858403150657e-15 14.228864067084025 -1.9497608496058798 RRS(ph)PPADAIPK ddPTM_A459_Selumetinib_30min_R1 2 RRSPPADAIPK 11 2 P18754-2;M0R1Q8;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4;C9JW69;P18754 P18754-2 RCC1 Regulator of chromosome condensation 1 RRS(1)PPADAIPK;RRS(1)PPADAIPK 95.195 0.024261 268830000.0 14747.400000000001 19299.1 20314.6 21701.8 17875.4 16557.8 17347.3 17309.800000000003 9923.0 14032.5 True False 15090.985726554873 17039.552400091823 17555.988900110286 17911.98802323943 16258.573226158192 16391.243565279536 16038.779194608644 16850.68787384541 16838.60625275488 15833.708063124921 0.9530923310187983 1.0761567872894657 1.1087730574619081 1.1312566804837467 1.0268329541847963 1.035211935191167 1.0129515544095014 1.064228783723058 1.0634657520287534 1.0 13.95071153634017 RRS(ph)PPADAIPK ddPTM_A459_Selumetinib_30min_R2 1 RRSPPADAIPK 11 2 P18754-2;M0R1Q8;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4;C9JW69;P18754 P18754-2 RCC1 Regulator of chromosome condensation 1 RRS(1)PPADAIPK 85.287 0.03966 241880000.0 49427.0 46243.0 44163.0 56695.0 58441.0 35350.0 48040.0 46282.0 40627.0 45520.0 True False 46680.04521195794 49789.68940531932 41321.60066103875 48973.04319566988 51099.11911083116 40219.14162464996 50273.95518945409 46416.67295760246 48753.535213224946 44205.71932483637 1.0559729809832867 1.1263178196343855 0.9347568887499763 1.1078440514857781 1.1559390932051146 0.9098176036704235 1.1372726415789454 1.0500151036231165 1.1028784500704516 1.0 15.431945416763076 -10.431691771884507 4.08521663192854 0.9999978887298603 1.0636590321943113 0.057015203328111386 0.07866343205252034 52494785.884737656 123767078.58826186 1780.0849812039328 0.01874655232024922 3.7009074794154766e-11 10.431691771884507 0.06366114346445106 RRS(ph)SDEDAAGEPK ddPTM_A459_Selumetinib_30min_R2 2 RRSSDEDAAGEPK 13 2 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 RRS(0.869)S(0.131)DEDAAGEPK;RRS(0.638)S(0.362)DEDAAGEPK 105.53 0.0082179 32425000.0 79152.0 69307.0 59747.0 73399.0 65677.0 51520.0 60212.0 84291.0 62374.0 89269.0 True False 74753.04871056096 74622.62404287054 55902.94306761502 63401.92957966258 57426.068100170436 58616.41234800473 63011.97730781456 84536.27285487381 74850.54287517404 86691.57202128343 0.8622873823560211 0.8607829146822961 0.644848648653994 0.7313505580922783 0.6624181193308146 0.6761489148404641 0.7268524014346475 0.9751383079559283 0.8634119918461932 1.0 16.40360412392947 -7.756496196733558 24.9770200691758 0.9394563830274667 0.7334467454001246 0.6033638310531383 0.07730557150981152 86.64555868305928 437811.2696801183 0.04039659700639278 0.022376479305899748 1.7518777759387948e-08 7.756496196733558 -0.20600963762734215 RRSSS(ph)S(ph)SS(ph)SSSAS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RRSSSSSSSSSASR 14 2 F5H0Q6;A0A0A0MQS2;Q8N2M8-3;Q8N2M8;Q8N2M8-4 F5H0Q6 CLASRP CLK4-associating serine/arginine rich protein 4 RRS(0.376)S(0.45)S(0.504)S(0.517)S(0.199)S(0.953)S(0.021)S(0.016)S(0.051)AS(0.912)R 89.911 0.015650999999999998 4650900.0 455.35 0.0 605.32 865.77 855.21 636.54 0.0 0.0 972.57 1252.1 True False 430.04346991047527 0.0 566.3743702225838 747.8506324634465 747.7708741255955 724.2176070651964 0.0 0.0 1167.1111758762943 1215.9486196535072 0.35366911311846305 0.0 0.46578807777583237 0.6150347312179618 0.6149691377080373 0.5955988562013147 0.0 0.0 0.9598359313972251 1.0 10.247866553133408 -8.287134686849258 21.63158807711297 0.9799207262736257 0.3408857882657231 0.5372147414010717 0.2409020692333181 140.14869038417297 117978.02447775567 0.2558930749234475 0.06628068910013606 5.162562389634906e-09 8.287134686849258 -0.6390349380079026 RRT(ph)CETGEPMEAESGDTSSEGPAQVYLPGR ddPTM_A459_Selumetinib_30min_R1 2 RRTCETGEPMEAESGDTSSEGPAQVYLPGR 30 2 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 1 RRT(0.5)CET(0.5)GEPMEAESGDTSSEGPAQVYLPGR;RRT(0.5)CET(0.5)GEPMEAESGDTSSEGPAQVYLPGR 100.71 1.345e-07 22906000.0 894.95 1053.26 967.05 1368.1399999999999 1191.2 913.75 878.19 859.65 500.18999999999994 825.91 True False 915.80059373044 929.9438295527098 835.7299216254147 1129.2200321685198 1083.4561703234408 904.5585046186196 811.9474212651752 836.8492894632641 848.785897567819 931.9235935446649 0.9826992256383387 0.9978756155486687 0.8967794435235105 1.211708813888291 1.1626019319914485 0.97063590930029 0.871259647131426 0.8979805804467551 0.9107891499338231 1.0 9.864067865970918 -6.994454754840135 24.588789975858706 0.9128545776148684 1.0497298563213366 0.32429396236995855 0.08893989506376658 150.6859990610098 668167.3547621248 0.03406035564767891 0.02994483068683889 1.0128502628998621e-07 6.994454754840135 0.1368752787064682 RRT(ph)CETGEPMEAESGDTSSEGPAQVYLPGR ddPTM_A459_Selumetinib_30min_R2 4 RRTCETGEPMEAESGDTSSEGPAQVYLPGR 30 2 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 1 RRT(0.499)CET(0.499)GEPMEAESGDT(0.001)S(0.001)S(0.001)EGPAQVYLPGR;RRT(0.5)CET(0.5)GEPMEAESGDTSSEGPAQVYLPGR;RRT(0.499)CET(0.499)GEPMEAES(0.001)GDTSSEGPAQVYLPGR;RRT(0.499)CET(0.499)GEPMEAES(0.001)GDT(0.001)S(0.001)SEGPAQVYLPGR 145.33 6.1516e-19 65629000.0 27941.3 27491.200000000004 32786.3 42150.0 41810.3 23927.6 31871.4 24107.7 32834.9 32794.0 True False 26388.434403886145 29599.686641859615 30676.86515302435 36409.097287194345 36557.71632517557 27223.40970687339 33353.48325198101 24177.849415755427 39402.79748376007 31847.152010955295 0.8285963653769929 0.9294296278573807 0.9632530137222829 1.1432449995738947 1.1479116346918512 0.8548145748639829 1.0472987738591992 0.7591840365329479 1.2372471318693008 1.0 14.958876742191674 -4.999829045889128 2.0317685675975996 1.0155840803857346 0.8192713903938326 0.1723764769556868 0.13336549351271595 0.8748421950390429 5.533051282216064 0.03585341335991339 0.27236756241340593 1.000393713872249e-05 4.999829045889128 -0.196312689991902 RRT(ph)TDFSDFLSIVGCTK ddPTM_A459_Selumetinib_30min_R1 1 RRTTDFSDFLSIVGCTK 17 2 Q9UHD1;E9PIZ4;E9PSD5;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 RRT(0.497)T(0.497)DFS(0.005)DFLSIVGCTK 104.52 0.008939299999999999 18295000.0 5835.1 4127.7 4296.1 3149.8 3977.8 3629.2 3629.0 4275.4 3318.8 3431.2 True False 5971.046476871876 3644.426965084332 3712.713216788115 2599.7465590688125 3618.008692337629 3592.693543049949 3355.2616082753393 4162.002503543578 5631.761204438469 3871.627942718281 1.5422573049928934 0.9413164227050107 0.958954029601669 0.6714866711194163 0.9344928660157915 0.9279542342923346 0.8666281104272641 1.0750006367144422 1.4546235557139804 1.0 11.918724603239063 -8.00709909648495 22.475631140847366 1.2398119742254747 0.9608964229708666 0.15223368381930646 0.23161353116843436 133.41300697184784 422373.66161292646 0.13399871022704177 0.059984425811586695 9.837866016018917e-09 8.00709909648495 -0.2789155512546081 RRVNDAEPGS(ph)PEAPQGK ddPTM_A459_Selumetinib_30min_R1 1 RRVNDAEPGSPEAPQGK 17 2 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 1 RRVNDAEPGS(1)PEAPQGK 143.72 0.00056022 6735000.0 3447.6 2463.6 9261.0 8822.0 6011.5 4186.1 3465.8 3335.5 2506.1 2236.8 True False 3527.9223721381777 2175.160566703431 8003.407067031664 7281.403309449829 5467.760886416527 4143.991634674696 3204.3719156684137 3247.031704769054 4252.668661697974 2523.91506827706 1.3977975790391786 0.8618200327114395 3.17102867985774 2.884963682403326 2.166380697647275 1.6418902865473894 1.2696037025746134 1.2865059310357962 1.684949194665667 1.0 11.301447647978943 -6.931084945125658 3.472419571621889 1.342281480211806 2.129643199110246 0.2527305583742816 0.6361740685986698 0.3922868939456351 9.548403897852223 0.2677188746655428 0.2287962529070386 1.1719661143152319e-07 6.931084945125658 0.7873617188984399 RRVS(ph)EVEEEKEPVPQPLPSDDTR ddPTM_A459_Selumetinib_30min_R1 4 RRVSEVEEEKEPVPQPLPSDDTR 23 3 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 RRVS(1)EVEEEKEPVPQPLPSDDTR;RRVS(1)EVEEEKEPVPQPLPSDDTR;RRVS(1)EVEEEKEPVPQPLPSDDTR;RRVS(1)EVEEEKEPVPQPLPSDDTR 67.214 0.0025869 226063000.0 11530.300000000001 14966.099999999999 12626.7 12038.0 13489.900000000001 11757.6 13847.0 14712.3 9177.6 11495.4 True False 11798.933555941772 13213.862054448862 10912.063493498403 9935.789281246543 12269.74092683529 11639.329219046655 12802.509641716339 14322.082011714498 15573.716894616868 12970.946564678166 0.9096432166386406 1.0187276609736555 0.8412696358809764 0.7660034085949585 0.9459402878312393 0.8973384603049938 0.9870142921241765 1.1041662950578854 1.2006615567306733 1.0 13.662996144747224 -7.575761788252659 2.4271237128686476 1.1176822220809397 0.8955162414210676 0.5884512229020041 0.07654591155157693 0.20774597808690018 2.454872036105007 0.04544125917759658 0.02336811263176855 2.656062020007187e-08 7.575761788252659 -0.22216598065987214 RRVS(ph)EVEEEKEPVPQPLPSDDTR ddPTM_A459_Selumetinib_30min_R2 3 RRVSEVEEEKEPVPQPLPSDDTR 23 3 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 RRVS(1)EVEEEKEPVPQPLPSDDTR;RRVS(1)EVEEEKEPVPQPLPSDDTR;RRVS(1)EVEEEKEPVPQPLPSDDTR 63.165 0.0044451 187494000.0 297514.0 289968.0 321747.0 307120.0 286812.0 251317.0 259287.0 283415.0 226249.0 377767.0 True False 280979.36292290594 312207.61320592585 301046.14831164567 265289.72618844936 250780.1124281873 285933.6355214192 271344.3592674434 284239.69072812086 271505.12192524475 366859.8851534599 0.7659037531600666 0.8510268520509604 0.8206025256365004 0.7231363714718412 0.6835855392673537 0.7794082893576965 0.7396403102343508 0.7747908731128276 0.7400785229261911 1.0 18.484869633985966 -10.697460944782609 4.929208249337089 1.000020071989825 0.7649032315522213 0.709902352221262 0.045211029187544736 1.0970980694215672e-05 1.8372455221753298e-06 0.04815731197687425 0.011678867305622719 2.0069615638652275e-11 10.697460944782609 -0.2351168404376036 RRYEDDGIS(ph)DDEIEGK ddPTM_A459_Selumetinib_30min_R1 2 RRYEDDGISDDEIEGK 16 2 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 RRY(0.022)EDDGIS(0.978)DDEIEGK;RRY(0.053)EDDGIS(0.947)DDEIEGK 110.33 0.0031822 32463000.0 6604.1 7124.5 7780.5 8405.9 6535.1 6295.0 6384.6 6679.7 4140.8 5580.9 True False 6757.962680658354 6290.360227909811 6723.95083522728 6937.9673632854565 5944.001358865618 6231.6780154026865 5903.00448172905 6502.532657276524 7026.635167933836 6297.262877569495 1.073158737700128 0.9989038650928374 1.0677576855140705 1.1017433285178733 0.9439023706692992 0.989585179554689 0.9373921013771283 1.0325966667896602 1.115823700637038 1.0 12.620509178192423 -4.746063666026261 23.50556720716667 1.0198778790796241 1.0731590490372735 0.06980965180649867 0.057175752463133715 1243.421838687652 1900644.843614291 0.015001684833891468 0.32085389298227074 1.7944705445506365e-05 4.746063666026261 0.05328116995764942 RRYEDDGIS(ph)DDEIEGK ddPTM_A459_Selumetinib_30min_R2 1 RRYEDDGISDDEIEGK 16 2 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 RRY(0.001)EDDGIS(0.999)DDEIEGK 97.256 0.0087267 18071000.0 51531.0 51510.0 51649.0 55659.0 54747.0 33518.0 41710.0 47199.0 30328.0 50279.0 True False 48667.113314937276 55460.65136924502 48325.95957117928 48078.148182869525 47869.19241561016 38134.800253890186 43649.59764679706 47336.34127578494 36394.447435121634 48827.31462946942 0.9967190226260065 1.1358529910996187 0.9897320779957955 0.9846568165322009 0.9803773313947314 0.7810136712059558 0.8939585962905405 0.9694643589351806 0.745370653932215 1.0 15.575400815372872 -6.159539075259689 1.4082299690776219 0.87966883060596 1.0556990656836267 0.4111957649464445 0.08293736973180009 0.38828335479440945 1.5496287871084475 0.02975893797997454 0.045555529786506135 6.925656136589748e-07 6.159539075259689 0.17603023507766669 RS(ph)ASPDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R1 3 RSASPDDDLGSSNWEAADLGNEER 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 RS(0.5)AS(0.5)PDDDLGSSNWEAADLGNEER;RS(0.5)AS(0.5)PDDDLGSSNWEAADLGNEER;RS(0.5)AS(0.5)PDDDLGSSNWEAADLGNEER 131.97 5.5329e-08 170774700.0 3812.0299999999997 5022.799999999999 5233.5 5431.5 4715.5 4658.8 4664.1 4164.82 2294.83 4180.16 True False 3900.8428820808376 4434.728240963627 4522.819445557736 4482.990486882425 4288.983857589142 4611.936701851954 4312.283181911549 4054.355444358042 3894.15890224826 4716.724254206469 0.8270237291488872 0.9402135893376952 0.9588899417904694 0.9504457426961953 0.9093140973344245 0.9777838290502009 0.9142538230988951 0.859570164768968 0.8256066482528359 1.0 12.20356954617893 -9.875544353608452 6.088711501452634 0.9999999980781642 0.911758114411028 0.2242136889116243 0.051210375809827215 6953956.619551641 1127892.193753049 0.05223647611511301 0.01305911902270797 1.3318510161430795e-10 9.875544353608452 -0.08824188366713615 RS(ph)ASPDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R2 4 RSASPDDDLGSSNWEAADLGNEER 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 RS(0.581)AS(0.419)PDDDLGSSNWEAADLGNEER;RS(0.606)AS(0.394)PDDDLGSSNWEAADLGNEER;RS(0.588)AS(0.412)PDDDLGSSNWEAADLGNEER;RS(0.5)AS(0.5)PDDDLGSSNWEAADLGNEER 127.92 6.7068e-08 152592900.0 332677.0 319992.0 369449.0 431338.0 348947.0 242734.0 204827.0 244469.6 211399.0 332135.0 True False 314188.1441515473 344534.3574635504 345679.0535656573 372589.0203004462 305109.1582342395 276168.4051801351 214351.8613570008 245180.9660618789 253684.706981578 322545.39955963317 0.9740896772376976 1.06817321820103 1.071722163880211 1.1551521764351218 0.9459417454125865 0.8562156073445291 0.6645633813089645 0.7601440491683376 0.7865085266382044 1.0 18.29914271438291 -6.671916748257551 2.584967057211131 0.78305672319836 1.0665175669355145 0.6297068913112465 0.09072407828253919 0.16144554276413967 2.1969748179783846 0.032291885418633044 0.03155561316404805 2.1285470370430984e-07 6.671916748257551 0.2834608437371545 RS(ph)ASPHDVDLCLVSPCEFEHR ddPTM_A459_Selumetinib_30min_R1 1 RSASPHDVDLCLVSPCEFEHR 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 RS(0.5)AS(0.5)PHDVDLCLVSPCEFEHR 103.73 0.00012123 5541900.0 791.25 857.06 831.36 746.3 1037.7 945.49 664.46 747.93 439.12 593.16 True False 809.6845854955139 756.715016763616 718.4658783335975 615.9727147860357 943.840218220815 935.979229036233 614.3392472401846 728.0924667809677 745.1545679441423 669.2978638676773 1.2097522332083697 1.130610237407274 1.0734620818626144 0.9203267305030811 1.410194577294237 1.3984494491398523 0.9178861616113596 1.0878451973139933 1.113337735217189 1.0 9.386504599577073 -7.29110676707646 24.985405212058733 1.0370877394439881 1.1801355259679944 0.228159555364292 0.14379597701619937 1371.3638410114556 1154935.2716976295 0.06570138207869664 0.044303656703546836 5.1155605899636686e-08 7.29110676707646 0.1430477865240063 RS(ph)ASPHDVDLCLVSPCEFEHR ddPTM_A459_Selumetinib_30min_R2 2 RSASPHDVDLCLVSPCEFEHR 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 RS(0.632)AS(0.368)PHDVDLCLVSPCEFEHR;RS(0.5)AS(0.5)PHDVDLCLVSPCEFEHR 89.669 0.00054469 13226800.0 27620.8 28980.0 32271.0 33649.7 37784.0 27331.4 17983.1 21523.1 17162.5 29303.0 True False 26085.746510822977 31202.6728146131 30194.71899400813 29066.552811029753 33037.23612675426 31096.05226025343 18819.34978283664 21585.728657658976 20595.47956031638 28456.94625166259 0.9166741322182075 1.0964870418163752 1.0610667331265038 1.0214220652481834 1.1609550734848813 1.0927403097033523 0.6613271015240129 0.7585398822053099 0.7237417317437248 1.0 14.796493232420149 -7.252497643274156 24.97618517510159 0.7657805009793519 1.0630894190573839 0.632613937616705 0.10116271517814646 364.03260420571297 1016822.8090278992 0.03736333832269724 0.028502120037122686 5.5911656164290154e-08 7.252497643274156 0.29730891807803195 RS(ph)DSLLSFR ddPTM_A459_Selumetinib_30min_R1 1 RSDSLLSFR 9 1 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 RS(0.703)DS(0.297)LLSFR 108.98 0.006003100000000001 11109000.0 875.49 842.53 1103.8 888.21 1150.6 1277.5 1207.8 824.87 544.01 928.88 True False 895.8872135930084 743.8861959184296 953.9100227393968 733.1007972666549 1046.5284331549294 1264.6495098771934 1116.6946735946412 802.9917680446255 923.1452370816465 1048.1107960574016 0.8547638445887581 0.7097400377103733 0.9101232678144786 0.69944971469076 0.9984902713449528 1.206599068184708 1.0654357132807204 0.766132522501608 0.8807706595086813 1.0 10.033575517256574 -6.278764715267114 24.39738155077365 0.989522620009826 0.795863852221038 0.37559295933089987 0.12167281173910226 714.2055054892148 1005735.2239050597 0.04134155542240461 0.04699505926338204 5.263023203542487e-07 6.278764715267114 -0.1936587677887881 RS(ph)DSLLSFR ddPTM_A459_Selumetinib_30min_R2 5 RSDSLLSFR 9 1 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 RS(0.987)DS(0.013)LLSFR;RS(0.99)DS(0.01)LLSFR;RS(0.875)DS(0.125)LLSFR;RS(0.878)DS(0.122)LLSFR;RS(0.921)DS(0.079)LLSFR 121.68 0.0031753 39827900.0 44969.5 47329.3 45248.0 55797.8 55775.4 39701.5 40443.600000000006 37493.9 41832.700000000004 51490.3 True False 42470.275217171635 50959.305122314254 42336.79294229745 48198.04338342617 48768.39561359754 45170.021250665945 42324.30753747304 37603.0010415507 50200.40890329769 50003.6412511341 0.8493436508727932 1.019111885600101 0.846674199778146 0.9638906723084496 0.9752968862540877 0.9033346396476971 0.8464245098653314 0.7520052560311866 1.0039350664719668 1.0 15.609745534910418 -6.995936410017484 24.076327888738426 0.8792042024683381 0.933563016342381 0.004817872369891285 0.08486822312736995 196.82269149852792 1166135.4189973772 0.02875715934633882 0.025244299357399566 1.0094006730618413e-07 6.995936410017484 0.054358813874042955 RS(ph)EDEPPAASASAAPPPQRDEEEPDGVPEK ddPTM_A459_Selumetinib_30min_R2 1 RSEDEPPAASASAAPPPQRDEEEPDGVPEK 30 2 Q96IZ0;H0YI16 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 RS(1)EDEPPAASASAAPPPQRDEEEPDGVPEK 82.581 4.209e-06 5115700.0 14118.0 13117.0 14162.0 15426.0 17036.0 11304.0 11772.0 9331.3 10501.0 19940.0 True False 13333.378078831864 14123.031722197371 13250.832338419734 13324.952188665724 14895.785376227639 12861.02339250477 12319.42132577547 9358.45253812012 12601.493422454912 19364.280389658114 0.688555309597398 0.7293341884132221 0.6842925258145203 0.6881201842017421 0.7692403268537175 0.6641622169121999 0.6361930873689945 0.48328429199559575 0.6507597064740395 1.0 14.24111026885469 -11.015545232395537 6.539071601126858 1.0001608958544768 0.6657780098368906 0.6652970039907036 0.07107178711062212 0.00018579430847566193 1.4414714652313543e-05 0.07669287550724842 0.01859191372901394 9.648388172204687e-12 11.015545232395537 -0.33438288601758615 RS(ph)HSPSIDGTPK ddPTM_A459_Selumetinib_30min_R2 1 RSHSPSIDGTPK 12 1 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 RS(0.718)HS(0.275)PS(0.007)IDGTPK 63.31 0.043653 2450600.0 24655.0 24933.0 28523.0 24102.0 26600.0 22222.0 22692.0 20675.0 15500.0 22929.0 True False 23284.773801784908 26845.280927769098 26687.861233494295 20819.26602173093 23258.270192982818 25282.87878876864 23747.222963344968 20735.160827069492 18600.43310618522 22266.98019330347 1.0457086501917099 1.2056094133430135 1.1985397661385784 0.9349838119491425 1.0445183851188526 1.1354426405953408 1.0664770326820816 0.9312066857321474 0.8353370301995006 1.0 14.442618295306348 -7.75227778747425 3.875850859196548 0.9072913801007031 1.0947754057477672 0.46366919205650825 0.0831061218686495 0.1946039735837688 6.386720171303154 0.04840455988972033 0.0239339906918846 1.7689771067896836e-08 7.75227778747425 0.18748402564706412 RS(ph)LSGSSPCPK ddPTM_A459_Selumetinib_30min_R1 1 RSLSGSSPCPK 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RS(0.518)LS(0.433)GS(0.024)S(0.024)PCPK 135.91 0.0026195 12027000.0 5867.6 6212.8 6655.7 7379.9 6305.6 5355.1 5790.2 5357.4 3595.3 4625.5 True False 6004.303663637889 5485.4024877476395 5751.8924971431425 6091.1390028801625 5735.259593344101 5301.2325560417685 5353.4405522832385 5215.304348712256 6100.961509677477 5219.227981185419 1.1504198868649842 1.050998827321156 1.1020581047384603 1.1670574699625806 1.098871253376726 1.015712012418688 1.0257150236743129 0.9992482350862413 1.1689394545841998 1.0 12.34962070638331 -6.643038707255889 5.906786757935353 1.0411746068975425 1.1141538438983456 0.3120488239028605 0.053809745734027824 0.27352047403350255 13.095379335891531 0.017751761784346447 0.01769777102822611 2.274894667767158e-07 6.643038707255889 0.07297923700080311 RS(ph)LSPILPGR ddPTM_A459_Selumetinib_30min_R2 1 RSLSPILPGR 10 1 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 RS(0.576)LS(0.424)PILPGR 65.563 0.04535 7942600.0 6515.4 9630.4 9360.8 7993.4 8671.0 6203.1 4947.7 5464.2 6854.9 7455.6 True False 6153.300151212716 10369.02071338337 8758.53631926843 6904.685130615879 7581.67146027647 7057.520718864676 5177.777853681557 5480.099917352996 8226.071541908968 7240.337456024833 0.8498637236987385 1.4321184304407104 1.209686202123117 0.9536413423479798 1.047143383347085 0.9747502463427266 0.7151293548304191 0.7568845997354575 1.1361447711340975 1.0 12.821841224344595 -5.799385109811043 5.437183557807266 0.924899882385906 1.1914509768724122 0.24292735730116655 0.17756602954747724 0.22446411132129007 16.313718253530496 0.05053501154812623 0.07847444124548028 1.5871387321409257e-06 5.799385109811043 0.26655109448650616 RS(ph)LTNSHLEK ddPTM_A459_Selumetinib_30min_R2 1 RSLTNSHLEK 10 1 F8VX12;F8VX04;Q9H2H9 F8VX12 SLC38A1 Sodium-coupled neutral amino acid transporter 1 1 RS(0.649)LT(0.339)NS(0.012)HLEK 63.754 0.048102 7339000.0 35884.0 14510.0 25291.0 37895.0 23123.0 15225.0 54777.0 34249.0 30153.0 21631.0 True False 33889.71093503346 15622.870342996406 23663.804594758774 32733.635627478783 20218.082017757217 17322.105551210643 57324.23903856637 34348.65891977284 36184.442545213096 21006.456825912468 1.6132997209328934 0.7437175375394507 1.1265014748021829 1.558265437086957 0.9624698817754571 0.8246086284214765 2.728886623462086 1.635147669330038 1.7225390671585252 1.0 14.358545221676565 -7.21622484785722 24.999499079729663 1.824574998646853 1.1307973609418631 0.29896521819730826 0.47238454596726914 492.0280602541006 272046.7525431863 0.17385365693917018 0.13466588894088402 6.078202322291263e-08 7.21622484785722 -0.6937776377049898 RS(ph)LTVSDDAESSEPER ddPTM_A459_Selumetinib_30min_R2 1 RSLTVSDDAESSEPER 16 1 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 RS(0.986)LT(0.014)VSDDAESSEPER 93.804 0.004988 3901700.0 17806.0 17474.0 17617.0 17475.0 18615.0 15453.0 16015.0 11996.0 13988.0 15574.0 True False 16816.413803065592 18814.19961223427 16483.541399939302 15094.874853943571 16276.417279788535 17581.51048163271 16759.72923312046 12030.906373955293 16785.990857375407 15124.338153888451 1.1118776657834848 1.2439684580443715 1.0898686099332817 0.9980519279822301 1.0761738539682073 1.1624647837639444 1.1081297616194563 0.7954666347407843 1.1098661433366424 1.0 13.884584390499011 -5.765798706176813 0.3441377490639293 0.9777784642415892 1.2367306922052133 0.21036500995329732 0.10111786076790837 5.205248028499527 0.8183367514121228 0.11230596289007935 0.531490986096565 1.7147519042650467e-06 5.765798706176813 0.25895222796362405 RS(ph)MGGAAIAPPTSLVEK ddPTM_A459_Selumetinib_30min_R2 1 RSMGGAAIAPPTSLVEK 17 1 H0Y6J6;Q5W012;Q96I25;Q5W011;Q5W010 H0Y6J6 RBM17 Splicing factor 45 1 RS(1)MGGAAIAPPTSLVEK 62.203 0.027413 1569900.0 826.1 2545.9 7856.9 9299.4 12876.0 8233.4 2466.5 5307.0 10223.0 7537.9 True False 780.1886691403172 2741.1623436412506 7351.395607945913 8032.8056776402245 11258.401767099504 9367.4761146363 2581.1971372770286 5322.442491378852 12267.8856544859 7320.261241183746 0.10657934784498951 0.37446236593572474 1.004253177002346 1.0973386622389523 1.5379781398729053 1.2796641821926975 0.35260997555049384 0.7270836813083694 1.6758808531950813 1.0 12.837679420143406 -5.180714327648505 2.6455877642382046 1.0808493671725736 0.12868426712313308 0.48164821901595267 0.3560579426807356 0.2760302371676084 3.619521844317944 0.10275451149288242 0.38196555394286674 6.59607632515065e-06 5.180714327648505 -0.9521651000494405 RS(ph)NSAPLIHGLSDTSPVFQAEAPSAR ddPTM_A459_Selumetinib_30min_R2 1 RSNSAPLIHGLSDTSPVFQAEAPSAR 26 1 Q96E09 Q96E09 FAM122A Protein FAM122A 1 RS(0.539)NS(0.441)APLIHGLS(0.009)DT(0.009)S(0.003)PVFQAEAPSAR 50.055 0.023474 2460200.0 4920.0 4449.2 5630.2 5607.5 5589.3 4305.5 4562.4 3689.2 1138.3 5822.3 True False 4646.566096320493 4790.439333567173 5267.959061698266 4843.748826522952 4887.122165024021 4898.5435435623895 4774.560640224093 3699.9349612200604 1365.9918067593953 5654.19507084787 0.821790907122651 0.8472363039375694 0.9316903636485809 0.856664611996949 0.8643356134317413 0.866355596540788 0.8444280008733636 0.6543698819830848 0.24158908379412514 1.0 12.465105941953944 -7.821756945035676 4.1468841524382745 0.5716406580782915 0.8651303508519362 0.25966392259899407 0.17343425685430316 0.2298765717784101 7.8646854937656805 0.09288360953613552 0.043233638529521244 1.5074504819578828e-08 7.821756945035676 0.2934896927736448 RS(ph)PGPGPSQSPR ddPTM_A459_Selumetinib_30min_R2 2 RSPGPGPSQSPR 12 1 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 RS(1)PGPGPSQSPR;RS(0.993)PGPGPS(0.001)QS(0.006)PR 104.81 0.0049225 3543600.0 6446.9 5355.5 5312.3 8331.099999999999 7445.2 4330.4 5149.0 6152.1 5176.0 5668.6 True False 6088.60710698549 5766.249629353366 4970.512401594912 7196.389808050883 6509.86741506751 4926.873292542697 5388.438702549943 6170.001592465017 6211.344629523531 5504.932789208426 1.1060275102579396 1.047469578676276 0.9029197252578338 1.307262065425812 1.182551661271706 0.8949924515338451 0.9788382363383524 1.1208132467230765 1.1283234268908635 1.0 12.426509234415832 -6.72760257982854 24.99932030695445 1.0292840980255569 1.1053523115143513 0.11946182799795202 0.11431542461068148 519.9015328505028 384112.5799317108 0.04074749076107979 0.040745130823089 1.8723947734143902e-07 6.72760257982854 0.07606821348879444 RS(ph)PILLPK ddPTM_A459_Selumetinib_30min_R1 1 RSPILLPK 8 1 Q8TD16;Q8TD16-2 Q8TD16 BICD2 Protein bicaudal D homolog 2 1 RS(1)PILLPK 91.701 0.013603 12510000.0 3505.3 2690.7 2861.9 2976.4 2498.2 3181.9 2807.6 2281.0 1773.9 2175.1 True False 3586.966669873525 2375.6715931275053 2473.269699291428 2456.6276139476827 2272.2382510930333 3149.892974934047 2595.820471588272 2220.5004702677898 3010.1787394701096 2454.2952722681666 1.4615057570308507 0.9679648655037336 1.0077311101225916 1.0009503101382584 0.9258210602317287 1.283420544596101 1.057664292034965 0.9047405564268913 1.2264941278594472 1.0 11.261093112396 -4.75536506744793 24.996392613654596 1.0407715069453036 1.461506446725157 0.5402397340523313 0.1161961288709096 156.09578042606088 642287.0046822367 0.02847012501551438 0.2542189617070934 1.756446526272698e-05 4.75536506744793 0.42073493977985343 RS(ph)PILLPK ddPTM_A459_Selumetinib_30min_R2 1 RSPILLPK 8 1 Q8TD16;Q8TD16-2 Q8TD16 BICD2 Protein bicaudal D homolog 2 1 RS(1)PILLPK 96.756 0.010689 14045000.0 41010.0 42544.0 43232.0 50973.0 49324.0 40129.0 32245.0 29597.0 25895.0 38076.0 True False 38730.8283760373 45806.98799947895 40450.50018744262 44030.38946667042 43127.47815784529 45656.40549520732 33744.456392255335 29683.122369952867 31074.723566752666 36976.64694667113 1.0474402514618513 1.238808593584573 1.0939472214931114 1.1907620918189912 1.166343671454177 1.2347362258415266 0.912588327463078 0.8027532191537754 0.8403878158982235 1.0 15.174326786207926 -7.348132159438108 5.236911379219362 0.8661754171928525 1.1635170493462168 0.7698571874957032 0.07298188770062723 0.09554625853196379 4.349050817414661 0.02951488965316648 0.019653790029152886 4.486088537386216e-08 7.348132159438108 0.2973416321533643 RS(ph)PLSDPPSQDPTPAATPETPPVISAVVHATDEEK ddPTM_A459_Selumetinib_30min_R2 2 RSPLSDPPSQDPTPAATPETPPVISAVVHATDEEK 35 1 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y9Y7 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 RS(0.936)PLS(0.029)DPPS(0.031)QDPT(0.003)PAAT(0.001)PETPPVISAVVHATDEEK;RS(0.698)PLS(0.118)DPPS(0.145)QDPT(0.011)PAAT(0.013)PET(0.013)PPVISAVVHATDEEK 95.227 1.9693e-11 30862000.0 94784.0 75509.0 107555.0 128305.0 115975.0 92061.0 102979.0 108842.0 97403.0 107886.0 True False 89516.28473041496 81300.29750029756 100635.02839702975 110829.63766152979 101405.18367034514 104741.56710344847 107767.72754901732 109158.71220023681 116886.32166721053 104771.05085850836 0.8543990348183611 0.7759805483872861 0.9605232320608844 1.0578269164370935 0.9678740724600656 0.9997185887244778 1.028602144065119 1.0418785657466958 1.1156356713942257 1.0 16.67688061733965 -5.428035710675199 3.859093507968503 1.0274156222750757 0.8167404969663965 0.8036736436912506 0.041885072996261916 0.09501761135846636 2.539237460713512 0.01154262592646642 0.025518531279980106 3.732194678659106e-06 5.428035710675199 -0.21067512530867916 RS(ph)PLSYPAVNR ddPTM_A459_Selumetinib_30min_R2 1 RSPLSYPAVNR 11 1 C9J637;A0A590UJ51;H0Y7H7;H0Y599;Q8N1I0-2;Q8N1I0;Q8N1I0-3;A0A590UJM5 C9J637 DOCK4 Dedicator of cytokinesis protein 4 1 RS(1)PLSYPAVNR 66.393 0.039933 2701900.0 13235.0 7040.0 11029.0 12058.0 13548.0 9636.2 9921.1 11679.0 9540.5 10812.0 True False 12499.451683902797 7579.94536283217 10319.40614746725 10415.679598789786 11845.979119343281 10963.49908128578 10382.4508082867 11712.983956437462 11448.866583842588 10499.829467050326 1.1904433041629405 0.7219112830945409 0.9828165476259149 0.9919855966685353 1.1282068110265342 1.0441597280880135 0.9888208985553553 1.115540399317356 1.090385955292936 1.0 13.358078276103827 -5.926439405941486 3.0296720538535835 1.0623648350332169 0.9401533854403342 0.11837127161728489 0.11404577126272719 0.4299682413694307 7.986282704419211 0.03237983027195174 0.050463859031447074 1.1845696301478045e-06 5.926439405941486 -0.12221144959288266 RS(ph)PPAPGLQPMR ddPTM_A459_Selumetinib_30min_R1 2 RSPPAPGLQPMR 12 1 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 RS(1)PPAPGLQPMR;RS(1)PPAPGLQPMR 109.1 0.0039941 22379000.0 4525.799999999999 5511.3 5053.5 5681.4 4928.1 3910.2 3802.6 3915.1 2167.33 3466.1000000000004 True False 4631.242334326189 4866.0344338661425 4367.262456888512 4689.250143086403 4482.354225126723 3870.8669381775344 3515.766820509174 3811.2588299629188 3677.800714479819 3911.007697673066 1.1841557706679129 1.244189428919122 1.1166591309669127 1.198987704850688 1.1460867816224425 0.9897364662515458 0.8989414218235754 0.9744953537755768 0.9403716378947558 1.0 11.933324660258343 -6.759986094997463 3.1697606014399398 0.9500387700334973 1.18432128098381 0.893496019127276 0.03784830272536098 0.0713729452715713 1.4869958838608053 0.013420420299233406 0.012503230849566019 1.7378564695939653e-07 6.759986094997463 0.2342825109503126 RS(ph)PPAPGLQPMR ddPTM_A459_Selumetinib_30min_R2 3 RSPPAPGLQPMR 12 1 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 RS(1)PPAPGLQPMR;RS(1)PPAPGLQPMR;RS(1)PPAPGLQPMR 128.51 0.0012528 163916100.0 146848.0 144531.0 172599.0 158718.0 168036.0 111164.0 132223.0 113492.0 117556.0 156707.0 True False 138686.77603912025 155616.0629595877 161494.16825158233 137100.334596178 146925.81541909988 126475.83195368014 138371.63149490402 113822.24293038808 141070.48478907824 152182.4617363164 0.9113190472593361 1.022562397690876 1.0611877768898241 0.900894446258394 0.9654582646565106 0.8310802079994103 0.9092482137308164 0.7479327225472647 0.9269825391148444 1.0 17.215442579507105 -6.3371072275915745 1.5924128004521685 0.8707545884530462 0.9938730525437712 0.2286098258429199 0.07679390729521636 0.4532202465689468 2.2911771774860643 0.027669376040719257 0.03525069481589575 4.6014294995981956e-07 6.3371072275915745 0.12311846409072502 RS(ph)PPEEPPDFCCPK ddPTM_A459_Selumetinib_30min_R2 2 RSPPEEPPDFCCPK 14 1 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9-3;Q9Y6K9;Q9Y6K9-2 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 RS(1)PPEEPPDFCCPK;RS(1)PPEEPPDFCCPK 120.9 0.0010264 16096400.0 56782.0 62971.0 73208.0 78001.0 85811.0 75535.0 68747.0 61371.0 54470.0 60187.0 True False 53626.28375635578 67800.67321632172 68497.87698284372 67377.12924076972 75030.65501992659 85939.2606115399 71943.87171959621 61549.57944948403 65365.522018961885 58449.24492539388 0.9174846283267772 1.1599922856636429 1.171920647910442 1.1527459307091412 1.283689038510209 1.470322853977583 1.2308776924565443 1.0530431920557313 1.1183296226049817 1.0 15.834896767019366 -4.171112180500945 1.4272084989818334 1.2039269857612585 3.853957436827078e-06 0.2837612522967149 0.123872131724909 8.015696230072551 4.317405112379436 0.037794084194306785 21.21680038621153 6.743538161359282e-05 4.171112180500945 -1.2039231318038217 RS(ph)PPWEP ddPTM_A459_Selumetinib_30min_R1 1 RSPPWEP 7 1 H0YAQ0;F5H8F7;Q9UBL3-2;Q9UBL3-3;Q9UBL3 H0YAQ0 ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 1 RS(1)PPWEP 82.831 0.028509 7089100.0 6843.9 8663.3 6529.9 6842.2 7339.6 7119.5 8304.8 8029.4 4582.8 7263.5 True False 7003.349554088784 7648.996808541092 5643.175446173207 5647.338214001087 6675.73447591163 7047.884293988792 7678.362249767162 7816.434228833051 7776.676885531096 8195.84097748141 0.8545004195824356 0.9332778453800157 0.6885413542891068 0.6890492665142607 0.8145270868790198 0.8599342414467653 0.936860814023106 0.9537074048055834 0.9488564879306475 1.0 13.000676276914534 -7.113578361596642 1.9248690409139209 0.9623498976595206 0.7913839380256277 0.561382438014358 0.068713450763126 0.297972870489475 2.1792394122347596 0.036679478828203146 0.025990206811052966 7.698775195554156e-08 7.113578361596642 -0.17096595963389294 RS(ph)PSAPAATSSASSSTSSYK ddPTM_A459_Selumetinib_30min_R2 1 RSPSAPAATSSASSSTSSYK 20 1 A0A087X0S7;A0A0C4DH00;A0A087WTU1;A0A0B4J2G4;Q15345-3;Q15345 A0A087X0S7 LRRC41 Leucine-rich repeat-containing protein 41 1 RS(0.82)PS(0.18)APAATSSASSSTSSYK 111.66 0.00017768 15659000.0 16302.0 14286.0 12661.0 13892.0 16128.0 12561.0 13209.0 13635.0 13584.0 14712.0 True False 15396.000102076558 15381.690263269935 11846.40504425451 11999.88563496333 14101.85645385063 14291.163732594869 13823.244673136955 13674.675592604235 16301.179568672262 14287.226333633414 1.0776059497169852 1.076604367011395 0.829160591959477 0.8399030962864024 0.9870254816817449 1.0002755887580632 0.9675247210577042 0.9571259860574071 1.1409618065822769 1.0 13.80243824398107 -8.236770234770697 24.35528868625577 1.0704809081041007 0.9635390291492532 0.1937970614789205 0.0842803427990192 821.7792309505087 811326.7211516671 0.06115608545062429 0.02309054224684993 5.797353265965419e-09 8.236770234770697 -0.10694187895484752 RS(ph)PSPAPPPR ddPTM_A459_Selumetinib_30min_R2 2 RSPSPAPPPR 10 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RS(0.994)PS(0.006)PAPPPR;RS(0.991)PS(0.009)PAPPPR 83.226 0.020880000000000003 12013200.0 5673.6 5524.200000000001 5265.799999999999 5291.1 5594.8 5090.8 7630.5 7217.3 5400.2 6761.0 True False 5358.284025220316 5947.88837689737 4927.004160969543 4570.443052343395 4891.931205853398 5792.011490318756 7985.3333695489055 7238.301148111662 6480.390894194934 6565.792362812367 0.8160909954400642 0.90589041630151 0.7504051131551666 0.6960992367394494 0.7450633427825923 0.8821496584515547 1.2162025431654828 1.1024261426706516 0.9869929684189933 1.0 12.680753411381165 -7.059475911803198 5.180898053540299 1.0835761575753162 0.7849710528952748 0.7591883266929873 0.07803234807673466 0.10801680403966554 5.995319812732157 0.032048935721829756 0.025108194269086136 8.720152663796705e-08 7.059475911803198 -0.2986051046800414 RS(ph)PSPLGTSVR ddPTM_A459_Selumetinib_30min_R1 1 RSPSPLGTSVR 11 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 RS(0.606)PS(0.393)PLGT(0.001)SVR 115.57 0.011022 10146000.0 2607.5 3098.3 3152.5 3241.5 3139.2 2817.1 2592.5 2482.0 1546.9 2443.6 True False 2668.2496766882177 2735.549595639408 2724.4078154429685 2675.432875491003 2855.259914270773 2788.762531722146 2396.9456377662746 2416.1692973277736 2624.9763188941374 2757.259862679641 0.9677178828168489 0.9921261440265068 0.9880852553358008 0.9703230775248313 1.0355425518347374 1.0114253536523354 0.8693216298578418 0.8762936457427778 0.9520235486049022 1.0 11.429019527683751 -7.24879644504156 24.907132919820015 0.914100842083222 0.9946244489736623 0.4197567241972928 0.039460671326906 614.6586472270803 1210905.7404707929 0.014976825667960447 0.011516146219474103 5.6390189618821117e-08 7.24879644504156 0.08052360689044036 RS(ph)PSPYYSR ddPTM_A459_Selumetinib_30min_R2 2 RSPSPYYSR 9 1 Q13595;Q13595-4;Q13595-3;P62995;H7C2L4;P62995-3;H7BXF3 Q13595;P62995 TRA2A;TRA2B Transformer-2 protein homolog alpha;Transformer-2 protein homolog beta 1 RS(0.995)PS(0.004)PYYS(0.001)R;RS(0.993)PS(0.007)PYYSR 78.548 0.026283 12611000.0 37691.0 20919.0 24709.0 30150.0 19947.1 18751.199999999997 40195.0 33785.0 26393.0 37096.0 True False 35596.28510902759 22523.42003481337 23119.249841125064 26043.517988348995 17441.166968663438 21334.007593554077 42064.14714488148 33883.30875659215 31672.337482035276 36024.94209301692 0.9881011055373098 0.625217383463312 0.6417567523476048 0.7229301832353888 0.4841414296692023 0.5922010239036433 1.167639549184319 0.9405513732431535 0.8791780261646734 1.0 15.136708490943658 -7.25013672100859 24.99691977603727 0.9918881886100257 0.6653222363515425 0.559651617214185 0.13933242168837448 554.8556422095727 1227118.5307857352 0.054455907576883726 0.04179780610846607 5.6216432139303784e-08 7.25013672100859 -0.32656595225848317 RS(ph)PTDSDVSLDSEDSGAK ddPTM_A459_Selumetinib_30min_R1 2 RSPTDSDVSLDSEDSGAK 18 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 RS(0.5)PT(0.5)DSDVSLDSEDSGAK;RS(0.494)PT(0.494)DS(0.013)DVSLDSEDSGAK 156.08 1.2546e-05 28512000.0 8877.1 9790.8 10569.4 11982.5 10280.7 9231.2 9644.9 8373.5 5790.7 8272.599999999999 True False 9083.919158170274 8644.488584380564 9134.133533558417 9889.981314382518 9350.81250020501 9138.342509258986 8917.37742784646 8151.407579038721 9826.394964005618 9334.468791947778 0.9731586617983408 0.9260825417122382 0.9785381190023178 1.0595119588287598 1.0017508985911796 0.9789890258288745 0.9553170755189503 0.87325886032962 1.052699964296007 1.0 13.188352208235298 -5.494364172975977 22.28803159901985 0.985074949616498 0.9502929677209154 0.0834977020866362 0.050149025324602116 533.958992447125 417356.49056058924 0.013731522957246207 0.028439307763107297 3.203581868706361e-06 5.494364172975977 -0.03478198189558257 RS(ph)PTEDFR ddPTM_A459_Selumetinib_30min_R1 1 RSPTEDFR 8 1 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 1 RS(0.987)PT(0.013)EDFR 91.636 0.013649 20655000.0 1331.5 1887.6 1444.7 1307.3 1475.9 1471.4 1976.5 1570.3 1021.4 1646.4 True False 1362.5213593520084 1666.5989144785667 1248.5176751690572 1079.004596060277 1342.4051055913092 1456.599051924307 1827.4110137107218 1528.6505429467384 1733.2411998955797 1857.7314772940583 0.7334328862945441 0.8971150754823338 0.6720657373947433 0.5808183848141162 0.7226044893994232 0.7840740546884449 0.9836787695348195 0.8228587186202745 0.9329880131116639 1.0 10.859326269497474 -7.072331882366612 4.114203618662814 0.9193670427977341 0.722238386035355 0.5781344345242296 0.08586822113883524 0.1957321379693261 6.316721978332158 0.03614005764409233 0.028200686278874412 8.465802209541897e-08 7.072331882366612 -0.19712865676237912 RS(ph)PTEDFR ddPTM_A459_Selumetinib_30min_R2 4 RSPTEDFR 8 1 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 1 RS(0.967)PT(0.033)EDFR;RS(0.916)PT(0.084)EDFR;RS(0.994)PT(0.006)EDFR;RS(0.996)PT(0.004)EDFR 99.568 0.033303 184082000.0 156243.0 138962.0 146921.0 161255.0 176159.0 138876.0 150678.0 161367.0 143898.0 143581.0 True False 147559.63955028512 149619.93856674517 137468.2628154899 139291.7908196089 154028.3315385586 158004.90840919057 157684.82556279283 161836.55125425523 172681.62084605402 139435.44346176027 1.0582649281045453 1.0730409345868934 0.9858918177657615 0.9989697551886026 1.1046569488682436 1.1331760740770542 1.1308805110663087 1.1606557646774969 1.23843419261912 1.0 17.08923780470345 -6.462582841690574 3.62331420571447 1.1415321318829297 1.0295167196178296 0.39788890410909494 0.059738304912509047 0.2305659175568491 5.999373310674093 0.019448340323080335 0.021508500711278754 3.4468085241504043e-07 6.462582841690574 -0.11201541226510003 RS(ph)PTS(ph)SPTPQR ddPTM_A459_Selumetinib_30min_R1 1 RSPTSSPTPQR 11 1 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 2 RS(0.994)PT(0.284)S(0.604)S(0.119)PTPQR 120.6 0.015742 45023000.0 5048.6 6058.6 5621.6 6438.0 6457.0 5073.6 5456.9 4628.9 2788.6 5034.2 True False 5166.2225571344725 5349.256295433278 4858.217597238441 5313.724156227385 5872.965490075944 5022.564190460219 5045.281639624607 4506.126535213749 4732.050528714327 5680.388607260537 0.9094840008888001 0.9417060460610012 0.8552614852844369 0.9354508157127682 1.0339020613077878 0.8841937652012922 0.888193042492876 0.7932778629712279 0.833050492824722 1.0 12.47177391555223 -6.983519530865022 24.996821231947187 0.8649448892485423 0.9338963718722589 0.14254909070481891 0.06463569386961476 396.17432871282574 600897.1502230718 0.022931254940673107 0.02021830078686923 1.0386768905366672e-07 6.983519530865022 0.06895148262371664 RS(ph)PTS(ph)SPTPQR ddPTM_A459_Selumetinib_30min_R2 1 RSPTSSPTPQR 11 1 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 2 RS(0.999)PT(0.49)S(0.497)S(0.011)PT(0.003)PQR 120.59 0.015756 4803500.0 6627.2 5681.7 5584.6 5907.8 8483.1 5994.5 4837.5 5395.0 5081.8 4242.0 True False 6258.88675478357 6117.468120455044 5225.292916052737 5103.147448476558 7417.377138123778 6820.18796234694 5062.4533353244005 5410.6985568096725 6098.3019973556175 4119.52243796037 1.5193233800863646 1.484994489672906 1.268422006372139 1.238771611352891 1.8005429633722836 1.6555773308820005 1.2288932543916156 1.3134285923415387 1.4803419787597922 1.0 12.008261385099688 -11.069934224886394 6.4142553134947535 0.9994527617838455 1.4400446197079926 0.35811639440202514 0.17802375064463538 0.0014972005227061682 0.00010572487456220647 0.1852348098871479 0.04487318167383065 8.512669552002853e-12 11.069934224886394 0.4405918579241471 RS(ph)PTSSAIPLQSPR ddPTM_A459_Selumetinib_30min_R1 3 RSPTSSAIPLQSPR 14 1 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 RS(0.309)PT(0.309)S(0.054)S(0.018)AIPLQS(0.309)PR;RS(0.95)PT(0.048)S(0.002)S(0.001)AIPLQSPR;RS(0.728)PT(0.263)S(0.009)SAIPLQSPR 178.67 0.00012887 78778000.0 5090.5 6770.7 5985.299999999999 6923.8 6362.5 5843.9 6286.9 5593.5 3233.5299999999997 4626.8 True False 5209.098745611263 5977.983296386965 5172.529134899538 5714.6883058227995 5787.012998390613 5785.115671836657 5812.6740713877725 5445.142209751367 5487.06424231286 5220.694848848489 0.9977788199515658 1.1450551065449668 0.9907740798220424 1.0946221664503661 1.1084756274669136 1.1081122033234065 1.1133908875501228 1.042991855950436 1.0510218277789447 1.0 12.350026119862228 -8.478024621406986 1.539947470893337 1.0023052643504078 1.0803970045320432 0.1911971673465931 0.047850343693075045 0.6160881000932265 3.2107852749787407 0.04375131945336448 0.012896208742262237 3.326406943988948e-09 8.478024621406986 0.07809174018163545 RS(ph)PTSSAIPLQSPR ddPTM_A459_Selumetinib_30min_R2 3 RSPTSSAIPLQSPR 14 1 Q9ULD2;Q9ULD2-4;Q9ULD2-7;Q9ULD2-3;Q9ULD2-6;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 RS(0.598)PT(0.247)S(0.074)S(0.074)AIPLQS(0.007)PR;RS(0.741)PT(0.113)S(0.113)S(0.033)AIPLQSPR;RS(0.659)PT(0.31)S(0.024)S(0.007)AIPLQSPR 150.12 0.00076683 65886400.0 75244.0 71054.0 81374.0 87721.0 77422.0 60175.0 65392.0 67372.0 50216.0 78488.0 True False 71062.23970559746 76503.61332538014 76138.48543331206 75773.2484728345 67695.55619853814 68463.56003573719 68432.8575717898 67568.0413659649 60260.603152270785 76221.84750368539 0.9323080197204815 1.0036966543179253 0.9989063231461386 0.9941145610406622 0.888138485429194 0.8982143870551933 0.897811583069815 0.8864655420835599 0.790594890124608 1.0 16.21791695689531 -6.26478686499318 24.139438291035887 0.8883083028081352 0.984977121762483 0.42192067999756544 0.050613027056787344 160.7873043442423 1159471.4745973456 0.014914218646220332 0.01761120104303359 5.435170032650529e-07 6.26478686499318 0.09666881895434776 RS(ph)PTSSPTPQR ddPTM_A459_Selumetinib_30min_R2 1 RSPTSSPTPQR 11 1 A0A0D9SFE4;A0A0D9SFB1;A0A0U1RQP1;Q05193-5;Q05193-3;Q05193-2;Q05193 A0A0D9SFE4 DNM1 Dynamin-1 1 RS(0.918)PT(0.021)S(0.021)S(0.021)PT(0.021)PQR 96.23 0.036701 3967200.0 5111.2 4312.3 4418.9 4829.1 5069.7 4767.1 2840.1 3339.7 3131.2 5780.8 True False 4827.139965754736 4643.039543770051 4134.592784934539 4171.3682493378465 4432.798962306956 5423.724753574793 2972.170277551387 3349.4179740829004 3757.5274930378832 5613.893283677817 0.859856025370034 0.8270623093726261 0.7364929427774681 0.7430437378398237 0.7896122598545205 0.9661253749414989 0.5294312035094896 0.5966301468218512 0.669326491111392 1.0 12.454785924114214 -7.265817548924936 24.98309004637204 0.6652328174412453 0.8119449617926767 0.15024867745925885 0.1313274511598197 577.2770363956995 3294088.4354918445 0.051832895468001954 0.036320314155662 5.422286377578101e-08 7.265817548924936 0.14671214435143143 RS(ph)PTVEPSTLPR ddPTM_A459_Selumetinib_30min_R1 1 RSPTVEPSTLPR 12 1 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 RS(0.848)PT(0.142)VEPS(0.005)T(0.005)LPR 73.273 0.028092 4583800.0 2873.1 4024.5 3721.3 3815.3 3149.0 2861.9 3712.7 3424.3 1642.9 2714.7 True False 2940.0376399205834 3553.30966906071 3215.9678996377206 3149.029477051002 2864.173506001105 2833.111884397292 3432.6480498880824 3333.4764403060026 2787.881307331551 3063.1581884172642 0.9598060103581209 1.1600150728411147 1.0498863270588756 1.0280335795122966 0.9350393710750621 0.9248989801147564 1.120623826372393 1.088248218100813 0.9101329855811499 1.0 11.580804157557878 -5.814155832807921 3.5807465749281313 1.0023106377499797 1.0682140705623502 0.09847967038574712 0.07809307508694602 0.5296367858615941 13.815531551651057 0.023239334032316344 0.03786408476225615 1.5340664329211732e-06 5.814155832807921 0.06590343281237043 RS(ph)PTVEPSTLPR ddPTM_A459_Selumetinib_30min_R2 2 RSPTVEPSTLPR 12 1 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 RS(1)PTVEPSTLPR;RS(0.976)PT(0.024)VEPSTLPR 133.05 0.00092242 37880000.0 46028.0 50819.0 49593.0 47501.0 56955.0 34273.0 40598.0 36086.0 31977.0 51094.0 True False 43469.948024682875 54716.65389116021 46402.24037277573 41031.281856204485 49799.8037158397 38993.79465068258 42485.88744341084 36191.00428564112 38373.29351203129 49618.78346184517 0.876078472542752 1.102740737955317 0.935174890139279 0.8269304282269612 1.003648220318294 0.7858676075899207 0.8562460519831318 0.7293811286903181 0.7733622397562164 1.0 15.5985987436577 -6.308808046583842 0.9233766440987213 0.8140353644120842 0.9829057948550983 0.20422805782553766 0.10087046485158166 0.7550402216687374 1.3805227084989402 0.04898336824515527 0.07452189349634254 4.911249000280533e-07 6.308808046583842 0.16887043044301409 RS(ph)PVPAQIAITVPK ddPTM_A459_Selumetinib_30min_R1 2 RSPVPAQIAITVPK 14 1 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 RS(1)PVPAQIAITVPK;RS(1)PVPAQIAITVPK 108.47 0.0025038 213580000.0 12000.599999999999 15186.1 14973.7 15432.2 15072.4 12328.4 14376.4 13803.0 7234.4 12401.2 True False 12280.190630897272 13408.104352173645 12940.35378464659 12737.255968271553 13709.104081248353 12204.387489291588 13291.97657349396 13436.899601537165 12276.248420329528 13993.014817917328 0.8775943419407465 0.9581998251731474 0.9247723920135594 0.9102581633774988 0.9797105384105331 0.872177128953262 0.9499008431316941 0.9602576554361905 0.877312614906291 1.0 13.772419206546427 -10.6543592228145 4.379745622494639 1.0000116150626959 0.9260537369544424 0.27847762405598564 0.03678159413200902 3.883715309418661e-06 7.701351469327467e-07 0.03315593057625001 0.008040231546426737 2.2163624169726785e-11 10.6543592228145 -0.0739578781082535 RS(ph)PVPAQIAITVPK ddPTM_A459_Selumetinib_30min_R2 2 RSPVPAQIAITVPK 14 1 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 RS(1)PVPAQIAITVPK;RS(1)PVPAQIAITVPK 140.8 0.0006511 181663000.0 286093.0 239387.0 286506.0 324243.0 281120.0 207722.0 254610.0 256048.0 219327.0 271371.0 True False 270193.09638102027 257747.21314947453 268072.5158841472 280080.54404962633 245803.19235531302 236333.81998742677 266449.86950014345 256793.05728897185 263198.52850840596 263535.8141234666 1.025261394849486 0.9780348602969002 1.0172147447046993 1.0627798160230644 0.932712668192241 0.8967806549310383 1.01105753078142 0.9744142675373307 0.9987201526434557 1.0 18.00763950972359 -4.755443062323139 23.971688357533885 0.9846907419581316 1.0252615065785835 0.06887864767186713 0.04343032411098849 382.3501535134353 1528269.5634958209 0.011581141161705588 0.10111974230634395 1.7561311146505784e-05 4.755443062323139 0.04057076462045195 RS(ph)PVPPS(ph)CQS(ph)PS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 RSPVPPSCQSPSPQR 15 1 A7MCY6 A7MCY6 TBKBP1 TANK-binding kinase 1-binding protein 1 4 RS(1)PVPPS(1)CQS(1)PS(1)PQR 78.249 0.023048 0.0 0.0 0.0 0.0 0.0 0.0 0.0 449.66 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 470.5700809843865 0.0 0.0 0.0 0.0 RS(ph)PVSPQLQQQHQAAAAAFLQQR ddPTM_A459_Selumetinib_30min_R2 1 RSPVSPQLQQQHQAAAAAFLQQR 23 1 A0A5K1VW61;A0A5K1VW79;A0A5K1VW71;A0A5K1VW93;Q7Z5Q1-7;Q7Z5Q1-5;Q7Z5Q1-4;Q7Z5Q1-6;Q7Z5Q1-3;Q7Z5Q1;Q7Z5Q1-8;Q7Z5Q1-9 A0A5K1VW61 CPEB2 Cytoplasmic polyadenylation element-binding protein 2 1 RS(0.5)PVS(0.5)PQLQQQHQAAAAAFLQQR 51.688 0.01859 4418000.0 1502.2 2628.0 2333.7 2745.1 2355.5 1230.9 1153.1 2462.3 913.31 3640.8 True False 1418.7137377830586 2829.5591496481447 2183.5522827404416 2371.2126444383684 2059.5810315628196 1400.4453020023109 1206.7214348243022 2469.464885344291 1095.99752001355 3535.6806440655614 0.4012561881583646 0.8002869700342984 0.6175762187134773 0.6706523815770279 0.582513309005922 0.3960893086746617 0.3412981986508638 0.6984411585614065 0.3099820459896794 1.0 11.78777225564996 -10.80575697288735 5.152355569135718 1.000091678989308 0.5459160259798037 0.43516570623172524 0.15840139143187312 0.00016794844542029203 2.3375550056739695e-05 0.15441313606051096 0.03744317169010282 1.5640226101677608e-11 10.80575697288735 -0.45417565300950424 RS(ph)PVSTRPLPSASQK ddPTM_A459_Selumetinib_30min_R2 2 RSPVSTRPLPSASQK 15 2 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 RS(0.961)PVS(0.019)T(0.019)RPLPSASQK;RS(0.584)PVS(0.208)T(0.208)RPLPSASQK 64.507 0.026886 20664000.0 59684.0 54160.0 58358.0 61621.0 63072.0 49212.0 49062.0 57221.0 46512.0 57090.0 True False 56367.00221398218 58313.89784815199 54603.309815386165 53228.11349784586 55148.33148916589 55990.50629794274 51343.48021450865 57387.50363655348 55815.69965386365 55441.663362366184 1.016690315468495 1.051806427000808 0.9848786364597226 0.9600742522811304 0.9947091797862723 1.009899467337214 0.9260811653309922 1.0350970760287135 1.0067464839402953 1.0 15.758682921451673 -5.272559434572157 24.56016169520555 0.9885114238902667 1.0342483711692132 0.2721847872558302 0.029097365215938944 637.5189462173363 1408049.6631837517 0.0076052964492480364 0.016099601781316582 5.338762059287675e-06 5.272559434572157 0.045736947278946505 RS(ph)QSTTFNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R2 1 RSQSTTFNPDDMSEPEFK 18 1 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 RS(0.613)QS(0.186)T(0.101)T(0.101)FNPDDMSEPEFK 140.51 0.00016298 8659900.0 46130.0 43716.0 44816.0 42962.0 37562.0 26351.0 35025.0 35022.0 29279.0 33449.0 True False 43566.27927302123 47068.87663090498 41932.58735197138 37110.50148641626 32843.125751459425 29980.611059438514 36653.73190072084 35123.90822179578 35135.61812361273 32483.24045906093 1.34119252443205 1.449020355288338 1.2908991455091923 1.1424507211091557 1.0110791068659564 0.9229562887121279 1.1283890210065723 1.0812932369251436 1.0816537274935556 1.0 14.987407939444026 -5.760714356405849 2.2217325600676086 1.0416788106070318 1.3938669462130862 0.8569851738933166 0.059653513493242376 0.1085325816520863 1.0928700780998624 0.01882320697890801 0.035738496956426585 1.7349447281327607e-06 5.760714356405849 0.35218813560605433 RS(ph)RSPLELEPEAK ddPTM_A459_Selumetinib_30min_R1 1 RSRSPLELEPEAK 13 2 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 RS(0.881)RS(0.119)PLELEPEAK 98.942 0.020471 0.0 1653.3 2018.9 2433.8 3124.6 2327.0 2274.0 2198.3 2382.4 1375.1 1822.8 True False 1691.8186732382087 1782.526249438853 2103.303327906454 2578.947266006225 2116.5232608652186 2251.125624626802 2032.4804611385161 2319.211012874168 2333.4442666696814 2056.7741355755647 0.8225592902862776 0.8666611557423312 1.0226224122163363 1.2538796659286735 1.0290499205800903 1.09449335524479 0.9881884578297411 1.127596352345788 1.1345165355342695 1.0 11.006167657826746 -5.307376108263196 3.4518919515780615 1.0909862605101668 0.8362750574730777 0.6328392627655348 0.07346318176676268 0.14023160404433385 3.4017645331746564 0.019481416594650212 0.04970975396190678 4.927468898309198e-06 5.307376108263196 -0.25471120303708905 RS(ph)SAIGIENIQEVQEK ddPTM_A459_Selumetinib_30min_R1 1 RSSAIGIENIQEVQEK 16 1 P47736-4;F2Z357;J3KPC5;P47736;P47736-3;A0A0A0MQY8;X6R8W7;P47736-2 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 RS(0.619)S(0.381)AIGIENIQEVQEK 85.177 0.032736 0.0 1511.9 1724.6 1764.8 1354.1 1452.5 1424.1 1665.1 1708.7 701.7 1328.2 True False 1547.1243283547153 1522.6830302552107 1525.1498533524978 1117.6318546050795 1321.121631459703 1409.7748469793437 1539.5001664202987 1663.3797253601795 1190.7336498597294 1498.687407763586 1.032319561998195 1.0160110923514278 1.017657081424605 0.7457404718391969 0.8815191377574492 0.9406730447432518 1.027232335739456 1.1098910398148707 0.7945176850698973 1.0 10.549483785828022 -9.827424900074126 17.88735595405896 0.9999999990391071 0.9539826045868696 0.01709689368343148 0.10859721879338081 0.0 0.0 0.10941478431583908 0.0265369831022576 1.487904646212712e-10 9.827424900074126 -0.046017394452237514 RS(ph)SCSSEPNTPK ddPTM_A459_Selumetinib_30min_R2 2 RSSCSSEPNTPK 12 1 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 RS(0.78)S(0.215)CS(0.004)SEPNTPK;RS(0.891)S(0.102)CS(0.005)S(0.002)EPNTPK 134.61 0.0028279 661720.0 13210.2 10275.5 10121.7 11401.2 11655.599999999999 8876.1 4892.6 1580.33 0.0 1201.14 True False 12476.029968620533 11063.597809059938 9470.480841673707 9848.336891832989 10191.319325613926 10098.702205786583 5120.1155945029805 1584.9284986622847 0.0 1166.459967263489 10.695634928551604 9.48476426071878 8.118993456664802 8.442927462771957 8.736964500824426 8.657564330714326 4.389448192135349 1.3587508728486597 0.0 1.0 10.187921079749739 -7.497350227881786 1.850535355986425 0.4619363801201313 9.077048219091994 0.9652237919806514 0.7082971933552804 0.0633827282166809 0.4254126203849147 0.4669062628576012 0.2392168478990965 3.181630726020561e-08 7.497350227881786 8.615111838971863 up RS(ph)SDEDAAGEPK ddPTM_A459_Selumetinib_30min_R1 3 RSSDEDAAGEPK 12 1 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 RS(0.95)S(0.05)DEDAAGEPK;RS(0.96)S(0.04)DEDAAGEPK;RS(0.937)S(0.063)DEDAAGEPK 195.6 0.00030455 8728700.0 3685.14 4123.84 4872.549999999999 4476.9400000000005 3804.54 4118.25 3684.62 3495.39 2524.63 3352.91 True False 3770.9965919658 3641.0188956787965 4210.884473001309 3695.1264715720154 3460.4200287460944 4076.824144071825 3406.6861468954176 3402.680902573138 4284.112718320323 3783.2886586091026 0.9967509572352267 0.962395213326754 1.1130222547040354 0.9766969441159429 0.9146592663162773 1.0775873881034068 0.90045631044919 0.8993976430611847 1.132377966606266 1.0 11.885425140472156 RS(ph)SDEDAAGEPK ddPTM_A459_Selumetinib_30min_R2 1 RSSDEDAAGEPK 12 1 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 RS(0.992)S(0.008)DEDAAGEPK 116.86 0.0025194 3050900.0 34971.0 32794.0 30587.0 34516.0 36231.0 28903.0 37310.0 36901.0 31089.0 38543.0 True False 33027.451820004884 35309.194350670194 28619.06572060759 29814.861256578908 31679.337870750413 32884.125894689045 39044.988928362436 37008.375800710615 37307.6686992382 37430.163443259444 0.8823753032783667 0.9433352970578278 0.7645990048638542 0.7965463816842636 0.846358523621551 0.8785461475352156 1.043142357300975 0.9887313438214552 0.9967273788636555 1.0 15.191913727500523 -7.143334903428953 4.433222786206991 1.0057408176923055 0.8461687129749098 0.7269503392245806 0.04682840022950772 0.13468015940729497 4.279766696340641 0.020178203269594824 0.015442282085345104 7.188943933574716e-08 7.143334903428953 -0.1595721047173957 RS(ph)SDPALIGLSTSVSDSNFSSEEPSR ddPTM_A459_Selumetinib_30min_R1 4 RSSDPALIGLSTSVSDSNFSSEEPSR 26 1 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.749)S(0.251)DPALIGLSTSVSDSNFSSEEPSR 237.73 3.6991e-46 484299300.0 10046.0 11392.599999999999 12942.259999999998 13075.68 12417.21 10299.47 11190.96 9647.599999999999 5153.47 9079.74 True False 10280.0522538868 10058.749095723944 11184.772178745403 10792.2579489126 11294.075547936482 10195.86668297054 10346.816877306408 9391.714308178662 8745.062195443381 10245.213073157165 1.0034005325688067 0.981799892681416 1.0917071317969869 1.0533951682458136 1.1023758576117244 0.9951834686273227 1.009917197760918 0.9166929219642389 0.8535754340098368 1.0 13.322662368426732 -7.623956980499585 2.3517818440595897 0.9116736561111436 1.0413035052808073 0.5089367442938295 0.04983779583940149 0.23300118551702897 2.5823204710360197 0.030252143592591457 0.014790239316756078 2.3770757387210676e-08 7.623956980499585 0.1296298491696637 RS(ph)SDPALIGLSTSVSDSNFSSEEPSR ddPTM_A459_Selumetinib_30min_R2 7 RSSDPALIGLSTSVSDSNFSSEEPSR 26 1 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.621)S(0.379)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR;RS(0.5)S(0.5)DPALIGLSTSVSDSNFSSEEPSR 182.72 3.8439999999999997e-22 291130400.0 383771.89999999997 368936.3 437711.5 426420.39999999997 457605.3 351786.5 323407.7 364770.30000000005 326298.60000000003 430148.39999999997 True False 362443.39415863843 397232.52789282 409549.61863424693 368341.2059037801 400116.831170713 400241.8971751042 338446.7988702005 365831.7211820257 391567.43754463823 417728.898032238 0.8676521922854067 0.9509337988442538 0.980419646721784 0.8817709467525361 0.9578385241133933 0.9581379192593368 0.8102068122758437 0.8757634985401292 0.9373721554557598 1.0 18.672207425468514 RS(ph)SDSWEVWGSASTNR ddPTM_A459_Selumetinib_30min_R2 2 RSSDSWEVWGSASTNR 16 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 RS(0.915)S(0.085)DSWEVWGSASTNR;RS(0.499)S(0.499)DS(0.001)WEVWGSASTNR 152.9 0.00028464 11318600.0 24675.0 26886.0 29946.0 34079.0 31508.0 21869.7 23183.0 21186.4 21056.3 30144.0 True False 23303.662281851266 28948.069747884343 28019.306962739553 29437.381410445938 27549.683354906116 24882.05266162965 24261.055436243016 21248.04891640266 25268.148362178563 29273.664396482185 0.7960623571489625 0.9888775575142219 0.9571506519732675 1.0055926382070373 0.9411081230478532 0.8499807992818188 0.8287672874721644 0.7258417883261665 0.8631699817264775 1.0 14.837315729181917 -6.794077953017162 4.316207116023658 0.8329143756545017 0.9461333292568281 0.18520637447613497 0.08267240023013575 0.26626452684435264 11.025273639616572 0.028779132444716957 0.0262276890631468 1.606652843459545e-07 6.794077953017162 0.11321895360232648 RS(ph)SDTSGSPATPLK ddPTM_A459_Selumetinib_30min_R2 1 RSSDTSGSPATPLK 14 1 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 RS(0.474)S(0.474)DT(0.028)S(0.018)GS(0.006)PATPLK 115.63 0.0014212 3734900.0 79096.0 64079.0 63928.0 77052.0 71068.0 48153.0 50904.0 53857.0 44148.0 64167.0 True False 74700.16096637517 68993.65325354021 59814.942079543645 66557.38467788603 62139.802484018925 54785.63866058754 53271.13686436244 54013.714953493676 52978.83359818487 62314.33198411201 1.1987637287906916 1.1071875611397262 0.9598906090302689 1.0680911205925445 0.9971992077177754 0.8791819941928604 0.8548777651655598 0.8667944152440773 0.8501869780405034 1.0 15.927276393592555 -4.894072875424771 0.5045309386812814 0.8774636325878366 1.3759726077796433 0.7140564436558148 0.06058110838266193 2.194722769932793 0.46653211283995544 0.04027799947345556 0.6424013513186606 1.2762246379661026e-05 4.894072875424771 0.4985089751918067 RS(ph)SGENVENNSQR ddPTM_A459_Selumetinib_30min_R2 1 RSSGENVENNSQR 13 1 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 RS(0.719)S(0.281)GENVENNSQR 156.2 0.00065601 919520.0 3060.1 2969.5 2995.3 3865.4 2487.3 3203.8 2985.8 2836.7 4741.7 4020.3 True False 2890.0318925508845 3197.251101552574 2802.585659036057 3338.925851813073 2174.823137255871 3645.094368799255 3124.64561625046 2844.9543273590352 5690.172494167641 3904.223493006148 0.7402321864329638 0.8189211266414402 0.7178343309640148 0.8552086881794232 0.5570437094986371 0.9336285116179733 0.8003244747253355 0.7286863399227426 1.4574402578030592 1.0 11.93081992542734 -8.24643013874729 24.99207784688213 1.2287201290459746 0.7712866143491226 0.6370154857186195 0.13880642186220937 392.5054093976011 653568.6334582161 0.08671063886977254 0.032488246938770615 5.669827698748111e-09 8.24643013874729 -0.457433514696852 RS(ph)SGFISELPSEEGK ddPTM_A459_Selumetinib_30min_R1 1 RSSGFISELPSEEGK 15 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 RS(0.5)S(0.5)GFIS(0.001)ELPSEEGK 106.76 0.0022622 119180000.0 6055.5 8018.7 8780.6 9018.6 7455.4 6928.3 7509.7 7010.0 4206.2 5712.4 True False 6196.5813680481315 7079.866876207505 7588.242748383355 7443.67081008889 6781.060386357776 6858.607592393086 6943.2372829058395 6824.072028310914 7137.614191306823 6445.642183487965 0.9613598135996656 1.0983958889843835 1.1772671414839675 1.1548377334934308 1.052037980595489 1.0640689317137444 1.0771986848250097 1.0587109606847842 1.1073550141507247 1.0 12.65410838704719 -6.346304639311416 24.999954837958846 1.0639046072316936 1.1036696551767204 0.08583620901114308 0.058848100385869566 221.46445251588227 65235.780069198474 0.019023103211164107 0.021570172112836402 4.5050058647056103e-07 6.346304639311416 0.03976504794502689 RS(ph)SGFISELPSEEGK ddPTM_A459_Selumetinib_30min_R2 2 RSSGFISELPSEEGK 15 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 RS(0.483)S(0.483)GFIS(0.033)ELPSEEGK;RS(0.5)S(0.5)GFIS(0.001)ELPSEEGK 71.545 0.024926 27826000.0 165489.0 155977.0 166645.0 179315.0 159278.0 140064.0 143084.0 127518.0 118710.0 170602.0 True False 156291.78388495574 167939.93435489704 155923.24212935704 154891.98766437135 139268.07367661342 159356.54462560025 149737.68951556736 127889.05626825873 142455.3170345318 165676.27698277074 0.9433564462654426 1.0136631352016783 0.9411319771844707 0.9349074622221207 0.840603592819124 0.9618549349836748 0.9037968032752155 0.7719213552919129 0.8598413703450508 1.0 17.33800751375223 -5.862628505217652 1.9980357867264422 0.8823749516004905 0.9767764653826811 0.22813029908106297 0.062227910470674885 0.43748785368292786 3.561622665494693 0.019747382918873714 0.03540334468082721 1.372054917847352e-06 5.862628505217652 0.09440151378219064 RS(ph)SGYTPR ddPTM_A459_Selumetinib_30min_R2 1 RSSGYTPR 8 1 F8W824 F8W824 KCNQ1 1 RS(0.999)SGYTPR 65.24600000000001 0.043831 4777400.0 2303.4 2442.3 3012.4 1595.4 2861.4 1946.6 4289.0 5142.3 2841.1 4719.9 True False 2175.3862492407784 2629.616556767756 2818.585463653129 1378.1037677814927 2501.925350759438 2214.7264805245736 4488.446998492268 5157.263241646406 3409.3993869666356 4583.624223227048 0.4745996057480521 0.5736981106440712 0.6149250737811871 0.30065810386420694 0.5458399792201958 0.4831823842150221 0.9792353779237664 1.1251496611595035 0.7438217491062754 1.0 12.162273057921643 -7.262227495954409 24.97662222680855 0.9724808594677316 0.5006286727832545 0.7887490574982191 0.11739364165061564 30.792805550451565 975846.744285181 0.046280248157562875 0.0333001223892061 5.467294952187503e-08 7.262227495954409 -0.47185218668447704 RS(ph)SIGLR ddPTM_A459_Selumetinib_30min_R2 1 RSSIGLR 7 1 Q96GN5-5;Q96GN5-2;Q96GN5;C9J8L0;C9IZR6;Q96GN5-4 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 RS(1)SIGLR 109.44 0.0081331 2594200.0 5834.4 5110.6 8738.5 8104.2 7589.9 4650.1 5566.8 6906.8 6024.3 5720.7 True False 5510.147404953717 5502.566586830976 8176.27442375942 7000.393979475217 6636.388907433098 5290.609065595048 5825.667230404937 6926.897644517708 7229.328333005912 5555.528526836367 0.9918313583192971 0.9904668044184177 1.4717365565244347 1.2600770467938966 1.1945558150544202 0.9523142649773813 1.048625203212196 1.2468476421382497 1.3012854309151936 1.0 12.43970845402158 RS(ph)SIRSVDMEEMGTGRAT(ph)DY(ph)VFR ddPTM_A459_Selumetinib_30min_R2 1 RSSIRSVDMEEMGTGRATDYVFR 23 3 O43147-5;O43147;O43147-2 O43147-5 SGSM2 Small G protein signaling modulator 2 3 RS(0.514)S(0.213)IRS(0.293)VDMEEMGT(0.376)GRAT(0.769)DY(0.835)VFR 53.578 0.013891999999999998 15393000.0 0.0 2507.2 11289.0 10636.0 19110.0 8961.5 5263.3 2338.7 13068.0 9113.0 True False 0.0 2699.494178081366 10562.678030533856 9187.358451876615 16709.230954432405 10195.86528060257 5508.053879031096 2345.5052298073724 15681.965150427643 8849.884011582475 0.0 0.3050315884986001 1.193538583862763 1.0381332048931333 1.8880734405743445 1.1520902722858868 0.6223871264100538 0.26503231304926056 1.771996687177316 1.0 13.111442831720849 -5.150519168007557 3.6032898410844356 1.099616329245449 0.0548762264210079 0.42663527206196283 0.45142075220242023 0.2425313958055724 5.629577792190247 0.12391202243306454 0.39778559998885427 7.07099991449658e-06 5.150519168007557 -1.0447401028244412 RS(ph)SITEPEGPNGPNIQK ddPTM_A459_Selumetinib_30min_R2 2 RSSITEPEGPNGPNIQK 17 1 Q13625-2;Q13625;Q13625-3 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 RS(0.486)S(0.486)IT(0.028)EPEGPNGPNIQK;RS(0.496)S(0.496)IT(0.007)EPEGPNGPNIQK 246.67 1.2518999999999999e-30 46060000.0 194004.0 184901.0 193716.0 226970.0 176080.0 139843.0 136966.0 165507.0 127487.0 154861.0 True False 183222.03433954495 199082.31214957853 181252.52346203316 196056.29445491132 153959.25622482767 159105.10388163864 143335.19039298015 165988.59796884126 152987.96228440254 150389.76055280038 1.218314555898355 1.3237757106454244 1.2052185121898453 1.303654542265714 1.0237349647935245 1.0579517069300632 0.9530914196958015 1.1037227359010542 1.0172764536764454 1.0 17.198346817366044 -6.266732830112457 24.950871720249985 1.0291048757498953 1.2629917309907017 0.8492397954474583 0.04886287746882785 147.22026407075862 693927.0205236912 0.014119245308631451 0.016493370949446744 5.410870872919412e-07 6.266732830112457 0.23388685524080643 RS(ph)SLLNAK ddPTM_A459_Selumetinib_30min_R2 1 RSSLLNAK 8 1 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RE77 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 RS(0.698)S(0.302)LLNAK 80.916 0.023097 19582000.0 87614.0 82108.0 87783.0 103250.0 101250.0 78268.0 82151.0 85530.0 77302.0 93373.0 True False 82744.7646266309 88405.41958116819 82135.13735090378 89187.17188381554 88530.06981351548 89048.70655383613 85971.1842791184 85778.87813974619 92764.55999834377 90677.078877811 0.912521285981554 0.9749478112356936 0.905798227814356 0.9835690892071728 0.9763224721079883 0.9820420734310472 0.9481027106636962 0.9459819306192557 1.0230210450796027 1.0 16.46845029559092 -1.5228787453212567 0.14677914966385072 1.0068906795751391 0.7277052887306392 0.3598205511427025 0.0281286714998279 88.66669792580025 0.8607351876074081 0.10576120278714167 5.243122526508515 0.02999999999717341 1.5228787453212567 -0.2791853908444999 RS(ph)SLLSLMTGK ddPTM_A459_Selumetinib_30min_R1 2 RSSLLSLMTGK 11 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 RS(0.992)S(0.008)LLSLMTGK;RS(0.938)S(0.061)LLSLMTGK 142.95 0.00045151 34868000.0 20045.6 15177.400000000001 16894.5 14170.400000000001 14392.9 15065.9 14781.099999999999 15247.8 8983.9 11981.099999999999 True False 20512.623478052283 13400.422952218169 14600.319694845735 11695.805651352062 13091.064736272881 14914.35072474271 13666.149726668118 14843.378812165356 15245.022141905125 13518.990890796802 1.5173191286057062 0.9912295274450292 1.0799859111366854 0.8651389549581032 0.9683462946324466 1.103214792081546 1.010885341743332 1.097964998428259 1.127674562772532 1.0 13.722699846910935 -4.758912399092507 24.99980528162956 1.0268392729264144 1.517319774218531 0.7951797096059805 0.07462961356376356 31.19249733674771 308528.37490075396 0.019516317089072827 0.12893721306311676 1.7421582461557506e-05 4.758912399092507 0.4904805012921165 RS(ph)SLPNGEGLQLK ddPTM_A459_Selumetinib_30min_R1 1 RSSLPNGEGLQLK 13 1 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 RS(0.5)S(0.5)LPNGEGLQLK 82.259 0.017148 17999000.0 2716.0 3085.5 3360.1 3644.7 2936.6 2981.7 3097.1 2792.7 1588.7 2171.8 True False 2779.2775155839713 2724.2482255899654 2903.8168757081394 3008.2215644923804 2670.9850484988397 2951.70680516699 2863.483253510484 2718.6285240319403 2695.9078659429288 2450.5716851234447 1.1341343460613633 1.1116786512012338 1.1849548794414733 1.227559096823909 1.0899436505830238 1.2044972293958016 1.1684960170288752 1.109385430565355 1.1001138560070833 1.0 11.258902634331383 -8.579306127606063 1.1535721108830177 1.0013820315932855 1.1604370886625477 0.5907537561976951 0.040282462592796914 0.3998235943172425 1.1526050928644986 0.03886260009420346 0.012242706550565613 2.6344737305330337e-09 8.579306127606063 0.15905505706926215 RS(ph)SLPNGEGLQLK ddPTM_A459_Selumetinib_30min_R2 1 RSSLPNGEGLQLK 13 1 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 RS(0.5)S(0.5)LPNGEGLQLK 63.894 0.041388 19612000.0 112800.0 98439.0 124140.0 138800.0 132780.0 95629.0 87216.0 111670.0 86663.0 107620.0 True False 106531.02757417712 105988.95476872691 116152.96755341254 119895.20055664466 116098.98933173895 108801.0267163692 91271.7168152253 111994.94121203638 103998.02156653727 104512.73096965913 1.0193114904355902 1.0141248227404596 1.1113762550816193 1.1471827350052808 1.1108597799960218 1.0410313241929827 0.873307165245947 1.071591376217596 0.9950751511481287 1.0 16.673319165911266 -7.0052680386633694 24.821385835091192 0.9861322102325139 1.0816570204585263 0.3685036626165742 0.05897649344690844 246.76797629796337 1162699.4655073013 0.022338304608007863 0.01912911996229609 9.879431658861513e-08 7.0052680386633694 0.09552481022601245 RS(ph)SLPSFETLDYGDEEDIETQLSSSGK ddPTM_A459_Selumetinib_30min_R2 1 RSSLPSFETLDYGDEEDIETQLSSSGK 27 1 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8;K7EPU8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 RS(0.332)S(0.308)LPS(0.332)FET(0.027)LDY(0.001)GDEEDIETQLSSSGK 91.175 1.2333e-05 3214100.0 26984.0 25836.0 31447.0 34333.0 25581.0 23913.0 26172.0 26134.0 19772.0 32391.0 True False 25484.337305510602 27817.538124166455 29423.73425690478 29656.7861722715 22367.28608295841 27206.798689399006 27389.04985883414 26210.0456132834 23726.952475838345 31455.78766807503 0.8101636994254973 0.8843376747611666 0.9353996971046249 0.9428085694503411 0.7110706086581109 0.8649218699111327 0.8707157534202112 0.8332344397112136 0.7542952898273534 1.0 14.941037867936172 -4.742927525370964 23.464991424180464 0.8608907033322347 0.8101633447692087 0.03706068845696864 0.08176159233945803 2469.352253721654 3129699.4556673537 0.02029137851624079 0.6041085683688385 1.8074757305877276e-05 4.742927525370964 -0.050727358563026015 RS(ph)SPAAFINPPIGTVTPALK ddPTM_A459_Selumetinib_30min_R1 1 RSSPAAFINPPIGTVTPALK 20 1 F6VRR5;Q9BY77-2;Q9BY77;Q6R954;F8WEE2;Q8WUT1;F8WCX5 F6VRR5 POLDIP3;PDIP46 Polymerase delta-interacting protein 3 1 RS(0.614)S(0.386)PAAFINPPIGTVTPALK 138.25 4.4483e-05 39125000.0 1944.8 2555.9 2916.9 3079.4 2513.1 2485.7 2665.3 1698.7 937.7 1863.8 True False 1990.110056077947 2256.6540397943254 2520.8010013848016 2541.640597497144 2285.790548723841 2460.696114835021 2464.2542751546607 1653.644957844759 1591.2084131017082 2103.036884949384 0.9463029727725604 1.0730453925674437 1.198648021546932 1.2085573085696575 1.0868998851529204 1.1700679776209657 1.171759892938811 0.7863128648285972 0.7566241108224812 1.0 11.038258438234823 -7.761722338437839 24.999998864238055 0.8286013065887288 1.1270408993587109 0.6378254645786181 0.0944262856265612 4.447973190895759 392846.93910486315 0.048579228114889295 0.02563724950404804 1.730922652533969e-08 7.761722338437839 0.2984395927699821 RS(ph)SPPGHYYQK ddPTM_A459_Selumetinib_30min_R1 1 RSSPPGHYYQK 11 1 D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;D6RDK6;D6RBN5;Q9NX40-3;Q9NX40-2;Q9NX40-4;Q9NX40 D6RI08 OCIAD1 OCIA domain-containing protein 1 1 RS(0.5)S(0.5)PPGHYYQK 77.37899999999998 0.034086 6590900.0 1435.6 1060.4 1657.6 1715.8 1642.9 1323.1 1372.9 1354.1 557.39 1175.1 True False 1469.0466868086692 936.247875033415 1432.5070245450472 1416.167739554977 1494.2999850775527 1309.7908152786806 1269.3410476718693 1318.1848692633112 945.8501198451117 1325.9355314432992 1.1079322123675135 0.7061036172809217 1.0803745661644224 1.068051731001928 1.1269778580041419 0.9878239056260565 0.9573173186558882 0.9941545708700096 0.7133454812961689 1.0 10.372794916275408 -8.055057634646435 23.85979986539359 0.8556979487128457 1.0008767296022543 0.17025262155909515 0.12970776809377982 331.086966278063 143476.7630730036 0.08618494458013555 0.032575431253519534 8.809319579350641e-09 8.055057634646435 0.1451787808894086 RS(ph)SPPPPPSGSSSR ddPTM_A459_Selumetinib_30min_R2 3 RSSPPPPPSGSSSR 14 1 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 RS(0.659)S(0.341)PPPPPSGSSSR;RS(0.83)S(0.17)PPPPPSGSSSR;RS(0.668)S(0.332)PPPPPSGSSSR 104.17 0.0032704 54188900.0 25593.98 19623.99 25221.25 25435.3 27770.38 17063.37 19179.4 22013.4 20528.98 24104.86 True False 24171.56905241968 21129.08693192682 23598.542233820714 21970.968261660142 24281.61659405288 19413.694331649338 20071.28010326012 22077.45534948546 24635.349627626732 23408.890059852285 1.0325807413601142 0.902609516209593 1.0081017157790704 0.9385736874103967 1.0372818417263352 0.8293299802772384 0.8574212639702907 0.9431226894157481 1.0523928970847662 1.0 14.51476890976574 -4.740621067222105 24.494756305500434 0.9475103782942227 1.0325811416019428 0.1019704591389714 0.0704865880958693 2952.0382843323164 3473126.0891790725 0.017974563778741875 0.7556065156355126 1.8171004367913e-05 4.740621067222105 0.08507076330772012 RS(ph)SPSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R1 2 RSSPSARPPDVPGQQPQAAK 20 2 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 RS(0.588)S(0.401)PS(0.01)ARPPDVPGQQPQAAK;RS(0.488)S(0.488)PS(0.024)ARPPDVPGQQPQAAK 83.31 0.003347 37453000.0 10766.5 12863.7 13630.5 13512.5 11836.7 10693.0 11894.4 11077.2 6354.4 9528.8 True False 11017.338502037861 11357.61202382812 11779.552966977115 11152.795536039537 10766.072574939113 10585.438128467193 10997.195831763616 10783.396672183408 10782.952692986559 10751.914298371976 1.024686227614935 1.05633394283545 1.0955772749007813 1.0372846384878889 1.0013168144922138 0.9845166018547981 1.0228128244501336 1.0029280714985052 1.0028867784613278 1.0 13.392305923354792 -6.103964616336393 3.988745368277583 1.0028833390607985 1.0596346901348974 0.6619018881298225 0.018270147859778523 0.1429135364376331 3.997620207665052 0.005674031481383772 0.007599664152790239 7.871099159944708e-07 6.103964616336393 0.0567513510740989 RS(ph)SPSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R2 3 RSSPSARPPDVPGQQPQAAK 20 2 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 RS(0.413)S(0.413)PS(0.174)ARPPDVPGQQPQAAK;RS(0.443)S(0.443)PS(0.113)ARPPDVPGQQPQAAK;RS(0.437)S(0.437)PS(0.126)ARPPDVPGQQPQAAK 77.57600000000002 0.0020475000000000003 116024000.0 109089.0 99445.0 115521.0 112693.0 102447.0 88265.0 87293.0 95349.0 72306.0 97220.0 True False 103026.27009786718 107072.11173392698 108088.50462975462 97344.0189937316 89576.69197219957 100422.70256010542 91352.29746779804 95626.44980412333 86769.22039844037 94413.00599210462 1.0912296353161646 1.134082223193709 1.1448476138848247 1.0310445893638012 0.9487749175117939 1.0636532700643317 0.9675817066500082 1.0128525069111791 0.919038849432424 1.0 16.52669799324508 -5.901713212008585 4.297537454222641 0.9889460929832659 1.123827799852206 0.715800880688028 0.03876968946431093 0.1114665085571639 3.711130120461253 0.010759004991128654 0.016422549519131097 1.2539689647073916e-06 5.901713212008585 0.13488170686894008 RS(ph)SPSSSSTQPQEESR ddPTM_A459_Selumetinib_30min_R1 1 RSSPSSSSTQPQEESR 16 1 Q4G0A6 Q4G0A6 FAM188B Protein FAM188B 1 RS(0.818)S(0.181)PS(0.001)SSSTQPQEESR 183.41 4.4723e-07 1951100.0 289.3 382.46 258.98 357.97 290.2 190.16 141.81 309.55 243.84 216.47 True False 296.04012712019227 337.68140539917 223.81193847531162 295.4572594291267 263.95146123897143 188.2471630514655 131.11315752811396 301.3397284398922 413.77867063103423 244.2560330963587 1.212007430757728 1.382489517734676 0.9163005541280452 1.209621132725795 1.0806343568792953 0.7706960629185451 0.536785748405199 1.233704341382692 1.6940366441953927 1.0 7.932250386812619 -5.255904405481672 24.58383216924618 1.0413135054983276 1.297248481764243 0.09756445138650205 0.2919905013377847 874.8383888973361 3885592.6429825863 0.0801122522000297 0.19917321714245428 5.547478075634497e-06 5.255904405481672 0.2559349762659153 RS(ph)SPSSSSTQPQEESR ddPTM_A459_Selumetinib_30min_R2 1 RSSPSSSSTQPQEESR 16 1 Q4G0A6 Q4G0A6 FAM188B Protein FAM188B 1 RS(0.591)S(0.404)PS(0.004)S(0.001)SSTQPQEESR 115.38 0.001029 4163800.0 3821.6 4298.4 4298.4 3492.1 3693.7 3734.9 3967.5 3804.6 5163.8 5012.7 True False 3609.210771076913 4628.073458465593 4021.8456237440596 3016.4699557914932 3229.6643839030316 4249.348572953471 4151.996611452104 3815.6707561145627 6196.704288627053 4867.970326441289 0.7414200434774245 0.9507193240943455 0.8261853203785271 0.6196566029597539 0.6634519455388844 0.872919982661427 0.8529215120519038 0.7838319669676364 1.2729544087334503 1.0 12.249104658542308 -8.247494919752713 24.55215102932261 1.1364771903079915 0.7906391403078026 0.6117457585240182 0.11075692738068132 365.11759062896544 642869.7179378709 0.07847562107828102 0.029308948207397278 5.655943732047025e-09 8.247494919752713 -0.34583805000018897 RS(ph)SPVPPVPERR ddPTM_A459_Selumetinib_30min_R1 1 RSSPVPPVPERR 12 2 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RS(0.5)S(0.5)PVPPVPERR 69.815 0.025491 8104700.0 513.28 654.86 667.55 774.12 891.36 622.43 827.18 502.42 426.67 397.17 True False 525.2384253309797 578.1886867638451 576.9003765896753 638.9344740321128 810.7366453823898 616.1689193212222 764.7851466335609 489.09418950983877 724.0278272561648 448.15063826341196 1.1720131145328356 1.2901659339465226 1.2872912082088508 1.4257136317109578 1.8090717186613907 1.3749147423037993 1.7065358862303772 1.091361135633062 1.6155903070043134 1.0 8.807839941134443 -5.734312369491951 3.8238698167088416 1.461934869498351 1.2460083344979014 0.10330998514179235 0.23879117205742856 0.43985410060249147 13.735168265099931 0.0644988416810546 0.11135675046464286 1.843688855432343e-06 5.734312369491951 -0.21592653500044956 RS(ph)SPVPPVPERR ddPTM_A459_Selumetinib_30min_R2 1 RSSPVPPVPERR 12 2 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RS(0.819)S(0.181)PVPPVPERR 55.899 0.043324 10177000.0 6427.7 8472.1 4859.5 7754.0 8762.5 4977.2 7202.0 9936.2 6363.9 8244.0 True False 6070.4741661218 9121.882827904885 4546.845060623549 6697.89182360392 7661.6764122560935 5662.764121476886 7536.90727049226 9965.112696973543 7636.857822222722 8005.974299515622 0.7582430243985515 1.1393844754731197 0.5679315084609555 0.8366117068361256 0.9569948797761743 0.7073172995096294 0.9414103753678373 1.2447095536612518 0.953894871069567 1.0 12.966861269108389 -7.5273228611455325 24.88629595019408 1.078193380621094 0.8353791154570521 0.31284295267075346 0.15823437053945777 140.50642682188646 786791.4319526906 0.0712000198645521 0.041315632079860866 2.96945767082631e-08 7.5273228611455325 -0.2428142651640418 RS(ph)SPVYVGR ddPTM_A459_Selumetinib_30min_R2 3 RSSPVYVGR 9 1 P21980-2;P21980;A2A299;P21980-3 P21980-2 TGM2 Protein-glutamine gamma-glutamyltransferase 2 1 RS(0.871)S(0.129)PVYVGR;RS(0.5)S(0.5)PVYVGR;RS(0.891)S(0.109)PVYVGR 83.081 0.020385 17745000.0 31666.9 25453.7 35367.7 29830.4 35754.0 27073.2 22345.5 23767.7 20202.4 26906.0 True False 29906.98047064462 27405.9169434547 33092.180687440174 25767.448059689734 31262.262875184508 30802.287553959653 23384.61002676824 23836.860072045438 24243.444502219132 26129.153869816517 1.14458281426373 1.048863544529586 1.2664849712438297 0.9861570025600939 1.1964514056192834 1.1788474937774918 0.8949623911772101 0.9122706456859647 0.9278312119484401 1.0 14.673372786733816 -7.263563806534333 24.997729334417173 0.9264552746936876 1.1346417580900168 0.6250239100106407 0.07698402165195153 121.15730123786355 1425622.861648039 0.02979910659999025 0.021196393973880394 5.4504981110153506e-08 7.263563806534333 0.20818648339632917 RS(ph)STSGDTEEEEEEEVVPFSSDEQK ddPTM_A459_Selumetinib_30min_R1 1 RSSTSGDTEEEEEEEVVPFSSDEQK 25 1 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.384)S(0.384)T(0.081)S(0.081)GDT(0.069)EEEEEEEVVPFSSDEQK 64.532 0.0012417 8101400.0 1748.8 1866.1 1737.6 2037.1 1815.1 1710.5 1845.9 2010.4 974.28 1362.8 True False 1789.5436374275573 1647.6161444736467 1501.643463953593 1681.358726102951 1650.924525481932 1693.2939230097377 1706.6622768573848 1957.077661300466 1653.282001404216 1537.728654796128 1.1637577487068516 1.0714609104374708 0.9765334470876988 1.093404041642097 1.0736123829992694 1.101165617047199 1.1098591884428752 1.272706764744483 1.0751454726734009 1.0 10.586585234699854 -7.093585591633936 2.4271615749569024 1.1372840878982649 1.0712790526010436 0.021929490594713386 0.07725306335889125 0.6511533455007049 7.531892059902323 0.03325772774959481 0.02480792531288692 8.061473085574866e-08 7.093585591633936 -0.06600503529722124 RS(ph)STSGDTEEEEEEEVVPFSSDEQKR ddPTM_A459_Selumetinib_30min_R2 1 RSSTSGDTEEEEEEEVVPFSSDEQKR 26 2 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.311)S(0.311)T(0.311)S(0.065)GDT(0.001)EEEEEEEVVPFSSDEQKR 97.689 1.2285e-06 3295500.0 15927.0 14846.0 15451.0 15546.0 18622.0 12417.0 8237.3 11971.0 10717.0 18946.0 True False 15041.841100832631 15984.640462586127 14456.899481776814 13428.607981654171 16282.53787720775 14127.329039696717 8620.350771900297 12005.833628094262 12860.699457999164 18398.97975238028 0.817536695146733 0.8687786321694381 0.7857446269490308 0.7298561204143349 0.8849696068120991 0.7678321966667233 0.46852330335246334 0.6525271395301723 0.6989898152551297 1.0 14.167338148712702 -7.013208630542932 24.797226580084352 0.6677859563999056 0.8148919248647205 0.11855214279478099 0.12929833507081748 849.6303290660532 1595052.1569724963 0.045756773128675765 0.03714699137529004 9.700438563381587e-08 7.013208630542932 0.14710596846481494 RS(ph)STSSEPTPTVK ddPTM_A459_Selumetinib_30min_R1 1 RSSTSSEPTPTVK 13 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 RS(0.28)S(0.28)T(0.28)S(0.054)S(0.105)EPTPTVK 76.71300000000002 0.022883 21237000.0 5484.6 6911.3 7377.1 7514.3 6683.2 5539.0 6950.3 7355.6 4870.6 4981.5 True False 5612.380508826157 6102.1217830238 6375.330339509695 6202.068565880625 6078.705740014791 5483.282689009609 6426.033275281365 7160.505593643908 8265.052465450766 5620.924048919067 0.998480047049461 1.0856082967705765 1.1342139271096723 1.103389498221972 1.0814424260338045 0.97551268106248 1.1432343186556888 1.2739018587203488 1.4704081381494878 1.0 12.456591605714733 -7.639364474494457 3.8167068126441395 1.2791169527651522 1.0693562433520458 0.32605238453255103 0.11603050410582554 0.2294702598593602 6.256311739502685 0.057202264936866504 0.030815450819638223 2.29422245153673e-08 7.639364474494457 -0.20976070941310643 RS(ph)STVAPAQPDGAESEWTDVETR ddPTM_A459_Selumetinib_30min_R1 1 RSSTVAPAQPDGAESEWTDVETR 23 1 Q02241;H7BYN4;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 RS(0.925)S(0.051)T(0.024)VAPAQPDGAESEWTDVETR 174.77 1.3447e-13 8690200.0 738.3 1261.1 963.25 1145.6 944.58 990.63 1078.1 1142.6 675.23 754.55 True False 755.5009535182784 1113.4498257305154 832.4459407535096 945.5424655753486 859.142905779144 980.6651616200736 996.7780490167106 1112.2945363121335 1145.8159931520386 851.4038424394023 0.8873591072288946 1.3077810672551244 0.9777333613722303 1.110568708342007 1.0090897679267785 1.151821395132911 1.1707464769724187 1.3064241442994189 1.345796126394145 1.0 9.733699790883025 -7.214805682209974 2.2253515166180575 1.239820579255144 1.0720175922420472 0.19521460060848406 0.13465018401764284 0.4592935384455621 4.453547905377374 0.060586925582716736 0.04087616026175351 6.098096853357152e-08 7.214805682209974 -0.16780298701309682 RS(ph)STVAPAQPDGAESEWTDVETR ddPTM_A459_Selumetinib_30min_R2 2 RSSTVAPAQPDGAESEWTDVETR 23 1 Q02241;H7BYN4;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 RS(0.782)S(0.109)T(0.109)VAPAQPDGAESEWTDVETR;RS(0.782)S(0.109)T(0.109)VAPAQPDGAESEWTDVETR 192.19 1.2319e-22 23118000.0 17658.7 16121.0 20703.3 19263.6 21552.0 17957.8 19393.2 22342.8 18910.1 24382.3 True False 16677.30014737698 17357.42886281498 19371.27221804867 16639.864448436463 18844.445082675393 20431.3239453222 20295.022226896785 22407.813848950344 22692.648392340205 23678.319646176587 0.7043278575753966 0.7330515476683219 0.8181016435081622 0.7027468459369056 0.7958522971336889 0.8628705182895574 0.8571141250799815 0.946343076020118 0.9583724154177663 1.0 14.531279081962888 -7.307252720102115 0.6283069632940615 1.0023318821017337 0.7277907477937399 0.8877400873651166 0.03397165504773333 0.24224052865684922 0.19287663063983723 0.030711064488292528 0.02129397885498968 4.928869048963657e-08 7.307252720102115 -0.2745411343079939 RS(ph)TGVVNIPAAECLDEYEDDEAGQK ddPTM_A459_Selumetinib_30min_R2 1 RSTGVVNIPAAECLDEYEDDEAGQK 25 1 Q96IZ0;H0YI16 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 RS(0.5)T(0.5)GVVNIPAAECLDEYEDDEAGQK 77.575 0.00013258 3615900.0 5119.8 4635.5 6793.3 7066.9 7836.3 5815.2 6204.1 5956.0 6638.4 6010.9 True False 4835.262012183269 4991.027944518255 6356.226473985796 6104.376028917528 6851.83393658915 6616.191014870284 6492.602943190928 5973.330973931123 7966.265492393543 5837.349698806221 0.8283317364337645 0.8550160949821038 1.0888891024098983 1.0457444463479575 1.1737919244396817 1.133423789262333 1.1122518399949057 1.023295036641836 1.3647058859644303 1.0 12.511097783175439 -5.261902395104201 1.7856989181614176 1.1279874849932097 0.8020810237510088 0.5666186791294633 0.09664588676931901 0.29716254993471364 1.6412321951805307 0.026396207470600543 0.11706393925912038 5.471389150345683e-06 5.261902395104201 -0.3259064612422009 RS(ph)TQGVTLTDLQEAEK ddPTM_A459_Selumetinib_30min_R1 1 RSTQGVTLTDLQEAEK 16 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RS(0.5)T(0.5)QGVTLTDLQEAEK 179.78 5.3776e-07 20369000.0 13862.0 866.19 7658.3 2241.6 4992.2 4775.9 6068.1 10733.0 9580.8 5929.1 True False 14184.957629243369 764.7760721191939 6618.344924030728 1850.1466400433837 4540.656391444499 4727.858782170243 5610.378331544664 10448.325974302576 16257.917846054015 6690.157739324711 2.120272523002599 0.11431360842567946 0.9892659010307235 0.2765475362663322 0.6787069256610416 0.7066886860349966 0.8386018013546812 1.5617458334184517 2.4301247413779294 1.0 12.707824511531618 -7.804789899947744 3.9309427610421075 1.7932917696744137 0.7609662736770426 0.29127195464741973 0.6004869674921602 0.23298569230812802 7.476586256657309 0.32573420150277216 0.1526196514378891 1.5675092057307893e-08 7.804789899947744 -1.0323254959973711 RS(ph)TQGVTLTDLQEAEK ddPTM_A459_Selumetinib_30min_R2 2 RSTQGVTLTDLQEAEK 16 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RS(0.5)T(0.5)QGVTLTDLQEAEK;RS(0.664)T(0.336)QGVTLTDLQEAEK 168.05 7.0316e-06 20626000.0 357568.0 75350.0 227620.0 403630.0 168987.0 297768.0 315179.0 278765.0 134643.0 51941.0 True False 337695.80201811536 81129.10271156316 212975.1770139177 348654.8976994134 147757.34229705227 338782.8391312243 329835.4480153405 279576.15999797004 161575.36223974844 50441.32837107482 6.6948237273577496 1.6083855309029886 4.222235692271075 6.912087943729626 2.9292912591450015 6.716374252457171 6.53899210561794 5.54260105803024 3.203233686692568 1.0 15.622318649052364 -6.748369322829614 24.982420169192537 5.0053253302197 4.435733160119655 0.0 2.1541430752078226 1469.9349388552032 2809663.8582736854 0.6993062974430384 0.6952539998643644 1.784968996534503e-07 6.748369322829614 -0.5695921701000444 RS(ph)TVLGLPQHVQK ddPTM_A459_Selumetinib_30min_R1 1 RSTVLGLPQHVQK 13 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 RS(0.5)T(0.5)VLGLPQHVQK 117.13 0.0018871 34600000.0 4774.2 4219.9 5091.4 4836.7 4550.2 4524.0 4514.7 4964.1 3323.0 3425.5 True False 4885.429571023927 3725.8321462217154 4400.015845058311 3992.061141103601 4138.635213403059 4478.492667463344 4174.152544194178 4832.435942330702 5638.888297682605 3865.1962921955774 1.263953807698811 0.9639438374047756 1.1383680187064797 1.0328223560506316 1.0707438640980789 1.1586714694169882 1.079932874980355 1.2502433452314259 1.4588879506762396 1.0 11.916325967269175 -7.791008198346952 6.70388111209428 1.2678736582457255 1.0956701968299467 0.1763619783308522 0.12835118810587687 0.23580788719161136 33.811872370953715 0.06459102568537417 0.03164642943874565 1.618049492801056e-08 7.791008198346952 -0.1722034614157788 RS(ph)TVLGLPQHVQK ddPTM_A459_Selumetinib_30min_R2 2 RSTVLGLPQHVQK 13 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 RS(0.5)T(0.5)VLGLPQHVQK;RS(0.5)T(0.5)VLGLPQHVQK 115.04 0.0028056 54515000.0 210274.0 164869.0 179981.0 253850.0 183934.0 170499.0 183959.0 175629.0 136193.0 150284.0 True False 198587.8128735153 177513.92216261057 168401.21840849612 219275.19208432507 160826.56652917672 193983.68961417803 192513.45800784318 176140.05131305385 163435.4055503664 145944.9104352747 1.3607039278124553 1.216307726204241 1.1538683870937767 1.5024517910925828 1.1019676263428309 1.3291569335006588 1.3190830528702897 1.2068940998882618 1.1198431316510251 1.0 17.155064374774632 -8.38517845954623 1.7291235676457593 1.003899405468257 1.2787169990167788 0.4249909551034351 0.10643562564671573 0.3251867920467263 2.0054357722937732 0.09657860165564501 0.028131187440620337 4.119282154764779e-09 8.38517845954623 0.27481759354852175 RS(ph)WGQQAQEYQEQK ddPTM_A459_Selumetinib_30min_R2 1 RSWGQQAQEYQEQK 14 1 Q5VZK9-2;Q5VZK9 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 RS(1)WGQQAQEYQEQK 157.47 0.00056224 6586100.0 34968.0 34808.0 27807.0 22368.0 26949.0 19633.0 24686.0 25754.0 15526.0 23190.0 True False 33024.61854799493 37477.66167463949 26017.927893972424 19321.439813047764 23563.425692883244 22337.267539370674 25833.94791438102 25828.939876195796 18631.633832685933 22520.44444514403 1.4664283659426562 1.6641617249574578 1.1553025943758646 0.8579510879597205 1.0463126405111471 0.9918661949048323 1.1471331295129688 1.146910752099529 0.8273208762850761 1.0 14.458947679102499 -5.389572898696746 4.332108980574526 1.0154514953088003 1.5615091897172797 0.8034817758830038 0.10933898038573689 0.08891925864517586 2.6812276566442708 0.02891291074400768 0.06363574788799364 4.07781107743909e-06 5.389572898696746 0.5460576944084794 RS(ph)YDVPPPPMEPDHPFYSNISK ddPTM_A459_Selumetinib_30min_R1 2 RSYDVPPPPMEPDHPFYSNISK 22 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 RS(0.986)Y(0.014)DVPPPPMEPDHPFYSNISK;RS(0.545)Y(0.455)DVPPPPMEPDHPFYSNISK 103.86 4.0606e-05 53749600.0 3450.7 3638.8999999999996 4392.1 4975.0 4234.4 3625.0 3559.0 3862.2 2314.5 3100.0 True False 3531.094596106627 3212.8558963212836 3795.6769440783683 4106.209642316128 3851.399267644038 3588.535791236657 3290.541764632661 3759.7619098063356 3927.5374556082993 3497.9151965570845 1.009485478545106 0.9185059430496262 1.0851254906963907 1.1739019992130666 1.1010556434972694 1.025907030212959 0.9407151345096827 1.0748579363807849 1.1228223770187686 1.0 11.772279597652469 -5.2710578127105805 24.91472562693692 1.067485523103738 0.963995709566534 0.279911899287805 0.06509343098478465 771.3135470595304 1997944.5447907452 0.018523364805316533 0.03934099218051155 5.357253377136659e-06 5.2710578127105805 -0.10348981353720388 RS(ph)YDVPPPPMEPDHPFYSNISK ddPTM_A459_Selumetinib_30min_R2 4 RSYDVPPPPMEPDHPFYSNISK 22 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 RS(0.94)Y(0.06)DVPPPPMEPDHPFYSNISK;RS(0.99)Y(0.01)DVPPPPMEPDHPFYSNISK;RS(0.774)Y(0.226)DVPPPPMEPDHPFYSNISK;RS(0.703)Y(0.297)DVPPPPMEPDHPFYSNISK 104.96 4.6065e-05 53005700.0 130994.0 125111.0 157035.0 174095.0 190435.0 141310.0 148853.0 148000.0 126725.0 150119.0 True False 123713.87789052977 134706.6114047297 146931.53906678065 150382.96066937406 166510.85278949936 160774.1698155385 155774.95944662383 148430.65549728114 152073.54099234325 145784.67441399622 0.8486068812638681 0.9240107847152212 1.007866839620793 1.0315416299680427 1.1421698025448503 1.1028194181713191 1.0685276766764757 1.0181499262108369 1.0431380500290999 1.0 17.153479539032745 -5.165381214462804 1.4515174508327662 1.0652454423582172 0.8318669474474539 0.7614431767489219 0.03905271014025598 0.3138064820408531 0.9709264418254897 0.012625567554830757 0.08627995013261347 6.833115875762499e-06 5.165381214462804 -0.23337849491076323 RS(ph)YSSPDITQAIQEEEKR ddPTM_A459_Selumetinib_30min_R2 1 RSYSSPDITQAIQEEEKR 18 2 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RS(0.459)Y(0.002)S(0.459)S(0.081)PDITQAIQEEEKR 97.083 0.0014095999999999998 23509000.0 40819.0 35066.0 42479.0 37602.0 38517.0 28887.0 30098.0 26475.0 22738.0 41387.0 True False 38550.44339140373 37755.44944503875 39745.94738763821 32480.542732931954 33678.15011365112 32865.922039922596 31497.61663805555 26552.03786682782 27286.235352802545 40192.049773660015 0.9591559427423849 0.939376062123159 0.9889007306535991 0.8081335218244624 0.8379306430826079 0.8177219680261587 0.7836777874090316 0.6606291049188733 0.6788963366253757 1.0 15.294622535520011 -6.063824962993201 1.0216941036626985 0.7621660386386236 0.971559929579464 0.36586290730078863 0.09221863900956465 0.5393578314642428 1.1562789983988724 0.03860922938880288 0.07538259039425566 8.633264306721751e-07 6.063824962993201 0.20939389094084038 RSAS(ph)ASHQADIK ddPTM_A459_Selumetinib_30min_R2 1 RSASASHQADIK 12 1 C9JXK0;A0A494C1L1;Q14739 C9JXK0 LBR Lamin-B receptor 1 RS(0.047)AS(0.806)AS(0.147)HQADIK 82.837 0.018264 18329000.0 148670.0 43005.0 112320.0 132450.0 63006.0 48932.0 147210.0 120670.0 99549.0 105960.0 True False 140407.51657316406 46303.34521713031 105093.45348476955 114410.08151100592 55090.622999213396 55671.93883952964 154055.5566910812 121021.12972200617 119461.5816314603 102900.65948285747 1.364495789228202 0.4499810346195509 1.0213098148537851 1.1118498373673285 0.5353767728611215 0.5410260645492189 1.49712895393781 1.1760967357276018 1.160940874741058 1.0 16.65089270282612 -7.262483665984309 24.996251452324138 1.2232163596263783 0.8268470676745601 0.27969413571625623 0.29115929472356217 122.77102800244793 2938617.7717275256 0.11590098929257185 0.08321774627647974 5.4640710011835015e-08 7.262483665984309 -0.39636929195181825 RSAS(ph)PDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R1 4 RSASPDDDLGSSNWEAADLGNEER 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 RS(0.293)AS(0.707)PDDDLGSSNWEAADLGNEER;RS(0.239)AS(0.761)PDDDLGSSNWEAADLGNEER;RS(0.228)AS(0.769)PDDDLGS(0.003)SNWEAADLGNEER;RS(0.369)AS(0.631)PDDDLGSSNWEAADLGNEER 168.78 3.9613e-16 222457900.0 5142.84 6399.6900000000005 6318.639999999999 6612.92 6044.53 5400.05 5801.65 4797.56 3100.09 4425.7300000000005 True False 5262.658165775357 5650.411319664833 5460.603393805092 5458.097661882447 5497.803328748446 5345.730399853108 5364.026869564786 4670.313124128864 5260.62630838485 4993.815555760837 1.0538351100501469 1.1314817811295717 1.0934731835471518 1.0929714165325983 1.1009223843692448 1.0704701325394976 1.0741339582269662 0.9352193872561467 1.053428235313221 1.0 12.285926821646438 -7.6111924523072405 7.360373327959011 0.9961063685211685 1.0914106332603477 0.6295047872180639 0.03252277977519018 0.1352426353946919 9.622836100062598 0.014435894139246225 0.008277778902994005 2.4479782097411166e-08 7.6111924523072405 0.09530426473917919 RSAS(ph)PDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R2 1 RSASPDDDLGSSNWEAADLGNEER 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 RS(0.257)AS(0.743)PDDDLGSSNWEAADLGNEER 117.49 7.729499999999999e-08 130580000.0 16233.0 16723.0 21049.0 22484.0 20638.0 13915.0 12279.0 13215.0 10419.0 21094.0 True False 15330.834845847685 18005.600327079883 19694.73025641838 19421.6404129366 18045.26993393909 15831.66494220664 12849.997830376917 13253.45346213898 12503.091131183479 20484.961411206044 0.7483946168168587 0.8789667681399752 0.9614238397171021 0.9480926042805348 0.8809032915272005 0.7728432885182847 0.6272893354511024 0.6469845461797571 0.61035463431939 1.0 14.322277554675981 -6.904352548553598 3.2979585276874386 0.6920037425569769 0.8918016148558462 0.289455849660307 0.11704777706584031 0.25609303295652525 5.5347735614136075 0.04293182836618078 0.037078137998171085 1.2463713328168429e-07 6.904352548553598 0.19979787229886925 RSASPDDDLGS(ph)SNWEAADLGNEERK ddPTM_A459_Selumetinib_30min_R1 1 RSASPDDDLGSSNWEAADLGNEERK 25 2 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 RS(0.057)AS(0.292)PDDDLGS(0.516)S(0.135)NWEAADLGNEERK 64.318 0.0027866 5551200.0 2075.7 2547.7 2536.9 2062.3 2623.5 2172.4 2612.0 2823.9 1523.2 2216.5 True False 2124.059771390887 2249.414099606403 2192.4029141942146 1702.1580191655385 2386.2048882165454 2150.5476283813814 2414.974737066737 2749.000998680056 2584.7591498736506 2501.009365538314 0.8492810145609779 0.899402509483303 0.8766072388226842 0.6805884226663694 0.9540967423378448 0.8598718813347987 0.9656000374660496 1.0991566191469917 1.0334863937294014 1.0 11.288294744656133 -7.402593710236489 2.3956782254559954 1.0503833065323323 0.8503221979663204 0.603434751439845 0.06979181455640844 0.20502504557418716 2.2970265501601785 0.03616587884481907 0.021400941261190427 3.957366652294735e-08 7.402593710236489 -0.2000611085660119 RSCFESS(ph)PDPELK ddPTM_A459_Selumetinib_30min_R2 2 RSCFESSPDPELK 13 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RS(0.004)CFES(0.134)S(0.862)PDPELK;RSCFES(0.028)S(0.972)PDPELK 162.26 0.00018656 34871000.0 221040.0 229850.0 234440.0 251060.0 243950.0 181793.0 197220.0 206030.0 157597.0 225410.0 True False 208755.48169322783 247478.7559157629 219356.38563897213 216865.19489734294 213302.82005932956 206833.33559745373 206391.12078401638 206629.51318989755 189120.80362809484 218901.8276144848 0.9536488752431705 1.1305467780360694 1.0020765382794696 0.9906961365314472 0.9744222895890307 0.9448680161853866 0.94284786487712 0.9439369028649665 0.8639526023563481 1.0 17.739924474087452 -6.1748072454212 1.1233637915180663 0.933531206643448 1.042609595646846 0.3629229367981909 0.05141408076062272 0.48178245349322385 1.254074429779057 0.02045672116495539 0.03353490749956306 6.686406170402156e-07 6.1748072454212 0.10907838900339795 RSDLDLGYEPEGSAS(ph)PTPPYLK ddPTM_A459_Selumetinib_30min_R1 1 RSDLDLGYEPEGSASPTPPYLK 22 1 O15169-2;O15169 O15169-2 AXIN1 Axin-1 1 RSDLDLGYEPEGS(0.296)AS(0.697)PT(0.007)PPYLK 103.33 4.5002e-05 17172000.0 1022.7 1045.8 1324.3 1531.9 1302.2 1217.6 1032.7 1042.5 775.46 687.99 True False 1046.526920172211 923.3572498207707 1144.4673338591979 1264.3824223244376 1184.4162399220832 1205.352049492346 954.8026075684595 1014.8495134827576 1315.8989826424777 776.3002180900993 1.348095615310968 1.189433196466787 1.4742586787813683 1.628728670764962 1.5257193187914535 1.5526880212114662 1.2299398935086256 1.3072900017721902 1.6950903168363547 1.0 9.600470882635907 -7.260142633707346 24.985529923792033 1.3336875591810793 1.453405012490617 0.11179948897221181 0.1950514516498748 346.5687154363375 6677724.999867348 0.0797189047349153 0.058296469621839625 5.493604198446786e-08 7.260142633707346 0.11971745330953776 RSDLDLGYEPEGSASPT(ph)PPYLK ddPTM_A459_Selumetinib_30min_R2 2 RSDLDLGYEPEGSASPTPPYLK 22 1 O15169-2;O15169 O15169-2 AXIN1 Axin-1 1 RSDLDLGYEPEGS(0.011)AS(0.145)PT(0.838)PPY(0.006)LK;RSDLDLGYEPEGS(0.094)AS(0.081)PT(0.806)PPY(0.019)LK 100.53 0.00016591 9575900.0 46560.0 50068.0 54888.0 59503.0 57433.0 39137.0 33914.0 35115.0 31145.0 50815.0 True False 43972.381594447615 53908.054606005826 51356.56583753587 51398.588751599666 50217.753082465475 44527.76649968676 35491.06819931613 35217.17883639882 37374.870264008976 49347.838916774184 0.8910700561499288 1.0924096331132658 1.0407054688686455 1.0415570343066918 1.0176282119903652 0.9023245491009942 0.7192020760862964 0.7136518966067203 0.7573760287059828 1.0 15.590699285865972 -6.977048038080884 3.132206550890108 0.7747485033507874 1.0235477307884098 0.5602936347957121 0.09029892699579647 0.16209338749229113 3.281493978616758 0.033895879217168155 0.027938954469561492 1.0542702752414568e-07 6.977048038080884 0.2487992274376224 RSDS(ph)LLSFR ddPTM_A459_Selumetinib_30min_R1 1 RSDSLLSFR 9 1 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 RS(0.049)DS(0.951)LLSFR 107.97 0.006305699999999999 12533000.0 1407.6 1575.3 1329.6 1935.7 1553.4 1149.7 1053.2 1092.9 807.07 1096.9 True False 1440.394341287185 1390.8631436628991 1149.0476229700132 1597.666332589212 1412.8952442750458 1138.1350618440777 973.7562760638154 1063.9127417604855 1369.5388439394214 1237.6977997107954 1.1637690085768533 1.1237501949085575 0.9283749419595829 1.290837176055842 1.1415510673164222 0.9195581200112161 0.7867480060894886 0.8595900728021678 1.1065211914083006 1.0 10.273443389133691 -6.764373574123777 24.69924462341349 0.9164743473167661 1.1271005449509628 0.41661648222350844 0.11447041736029133 64.17581775919633 540209.8636406017 0.04037256052739733 0.03717100570295395 1.720388084225045e-07 6.764373574123777 0.21062619763419665 RSDS(ph)PEIPFQAAAGPSDGLDASSPGNSFVGLR ddPTM_A459_Selumetinib_30min_R1 3 RSDSPEIPFQAAAGPSDGLDASSPGNSFVGLR 32 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 RS(0.261)DS(0.739)PEIPFQAAAGPSDGLDASSPGNSFVGLR;RS(0.102)DS(0.898)PEIPFQAAAGPSDGLDASSPGNSFVGLR;RS(0.236)DS(0.764)PEIPFQAAAGPSDGLDASSPGNSFVGLR 118.86 6.4925e-17 59244000.0 5908.400000000001 5154.8 5582.9 6886.599999999999 5806.099999999999 4643.8 5073.9 4061.5 3170.3399999999997 3809.3999999999996 True False 6046.05422425491 4551.2736195984935 4824.77284467456 5683.984587492314 5280.9392801502145 4597.087588233042 4691.1716379796735 3953.7758263887 5379.835427527858 4298.373596698245 1.4065911415655283 1.0588362126304032 1.122464750011647 1.3223570403136695 1.2285901077111394 1.0694946553189912 1.0913829457688724 0.9198306609331854 1.2515979140715754 1.0 12.06957516591079 -6.766194741590435 20.47242350978122 1.0630078972150268 1.217787630568635 0.31242254256315594 0.11913578791502998 16.34493934366032 70362.66910731843 0.04036999756863137 0.03693133225116444 1.7131889257712064e-07 6.766194741590435 0.15477973335360828 RSDS(ph)PEIPFQAAAGPSDGLDASSPGNSFVGLR ddPTM_A459_Selumetinib_30min_R2 3 RSDSPEIPFQAAAGPSDGLDASSPGNSFVGLR 32 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 RS(0.269)DS(0.731)PEIPFQAAAGPSDGLDASSPGNSFVGLR;RS(0.27)DS(0.73)PEIPFQAAAGPSDGLDASSPGNSFVGLR;RS(0.284)DS(0.716)PEIPFQAAAGPSDGLDASSPGNSFVGLR 119.46 5.8395e-17 25171800.0 66480.0 70008.0 77290.0 76123.0 78133.0 53486.0 46233.2 49546.0 41258.7 68599.0 True False 62785.30774052578 75377.38848880022 72317.24554698917 65754.91608050036 68317.23402211751 60853.21100243363 48383.1354093478 49690.170657218165 49511.59286439772 66618.3686283931 0.942462402385614 1.131480551696878 1.0855451287074476 0.9870388217893896 1.0255014559603062 0.9134599398835724 0.7262731946985362 0.7458929373428089 0.7432123284282229 1.0 16.02363240482343 -6.956855855492657 2.771547508553093 0.7833039481836428 1.0416555223285813 0.5997063815095587 0.08784591762101907 0.16559605230766833 2.5844165896584563 0.03381283256359784 0.027971264095926082 1.1044451299295053e-07 6.956855855492657 0.2583515741449385 RSDS(ph)VSASER ddPTM_A459_Selumetinib_30min_R1 1 RSDSVSASER 10 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 RS(0.004)DS(0.938)VS(0.058)ASER 98.337 0.035321 2062400.0 816.33 1053.8 1069.4 1787.4 1378.9 1195.7 842.64 946.55 715.65 747.89 True False 835.3489006983293 930.4206061016707 924.1813537937221 1475.264143653437 1254.1787384645675 1183.672343608737 779.0789863866436 921.4444191722824 1214.4057809920416 843.8889665655087 0.989880107211336 1.102539128919213 1.0951456772269348 1.7481732812048996 1.4861892833708583 1.4026399094019344 0.9232008205503253 1.0919024370260604 1.4390587258587777 1.0 9.720909380741475 -11.031342733448627 5.913120243281189 0.9996831685400546 1.2554699602944484 0.08658759751083411 0.2466046629973072 0.0011196004094053236 9.306830072385475e-05 0.2595385376424004 0.06287054633717382 9.303733602058025e-12 11.031342733448627 0.2557867917543938 RSEACPCQPDS(ph)GSPLPAEEEK ddPTM_A459_Selumetinib_30min_R1 1 RSEACPCQPDSGSPLPAEEEK 21 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3 A0A0G2JMS7 SCRIB Protein scribble homolog 1 RS(0.002)EACPCQPDS(0.616)GS(0.382)PLPAEEEK 94.192 0.00023671 27585000.0 2142.7 2273.2 2858.7 2196.5 2765.2 2849.8 2477.6 3080.9 1550.3 2471.9 True False 2192.6207410315815 2007.052687217991 2470.5042417150867 1812.9225084115335 2515.088148235712 2821.133599411371 2290.712637272796 2999.184523826404 2630.7458705679633 2789.1924433449876 0.7861131082092144 0.7195820037469333 0.885741766442007 0.6499811487504801 0.9017262879213342 1.0114517577095101 0.8212816733884519 1.0752877704736572 0.9431926709987051 1.0 11.445631762764888 -6.475285515007511 6.898199037696631 0.9648891334619678 0.7667604006368246 0.5938338610349803 0.08191802836069001 0.1665047382456548 19.861436733723583 0.024412374324401916 0.027337006481183136 3.347452976787866e-07 6.475285515007511 -0.1981287328251432 RSEACPCQPDSGS(ph)PLPAEEEK ddPTM_A459_Selumetinib_30min_R1 3 RSEACPCQPDSGSPLPAEEEK 21 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3 A0A0G2JMS7 SCRIB Protein scribble homolog 1 RSEACPCQPDS(0.007)GS(0.993)PLPAEEEK;RSEACPCQPDSGS(1)PLPAEEEK;RSEACPCQPDS(0.003)GS(0.997)PLPAEEEK 192.89 8.6539e-17 75075000.0 10975.7 12253.1 13455.3 11256.0 12514.7 11250.5 11694.6 13242.400000000001 5985.900000000001 10336.3 True False 11231.412455005513 10818.501355688355 11628.144164672402 9290.350901288519 11382.74759464974 11137.330184636685 10812.466906623522 12891.168534622611 10157.63510716169 11663.064789088055 0.9629898022613751 0.9275864921722914 0.9970058792395352 0.7965617159205491 0.9759653916438344 0.9549231172115886 0.9270690939434417 1.1052985444000591 0.8709233199720503 1.0 13.509659325465686 RSEACPCQPDSGS(ph)PLPAEEEK ddPTM_A459_Selumetinib_30min_R2 4 RSEACPCQPDSGSPLPAEEEK 21 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3 A0A0G2JMS7 SCRIB Protein scribble homolog 1 RSEACPCQPDS(0.009)GS(0.991)PLPAEEEK;RSEACPCQPDSGS(1)PLPAEEEK;RSEACPCQPDS(0.084)GS(0.916)PLPAEEEK;RSEACPCQPDS(0.004)GS(0.996)PLPAEEEK 204.73 1.6700999999999998e-17 157279000.0 198592.0 123505.0 183576.0 178765.0 145156.0 106206.0 242783.0 178545.0 119944.0 155987.0 True False 187555.0516667642 132977.43636883347 171764.9200224361 154416.89861317407 126920.20556889525 120834.91245792282 254072.89056538793 179064.53639028387 143936.1515153726 151483.25000710145 1.2381240279566996 0.8778359083436589 1.13388721204743 1.019366158343811 0.8378497659836669 0.7976783733664161 1.6772342193178265 1.1820748259750793 0.9501786600738031 1.0 17.208798753497092 RSEDES(ph)ETEDEEEKSQEDQEQK ddPTM_A459_Selumetinib_30min_R2 2 RSEDESETEDEEEKSQEDQEQK 22 2 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 RS(0.005)EDES(0.497)ET(0.497)EDEEEKS(0.001)QEDQEQK;RS(0.055)EDES(0.767)ET(0.178)EDEEEKSQEDQEQK 64.346 0.0029529 92109000.0 34020.0 30020.0 27050.0 27898.0 19528.4 17231.4 25012.0 26652.0 21475.2 24554.0 True False 32129.304592850254 32322.43747048604 25309.632449813143 24098.24427326569 17075.06780588893 19604.868938924858 26175.10756033776 26729.552907523885 25770.840067222507 23845.062221046428 1.3474196164810963 1.3555191079332645 1.0614202728929782 1.0106177979269768 0.7160840113395854 0.822177302671115 1.097716051973006 1.1209680503132222 1.080762122921882 1.0 14.541402926839405 -5.349825610008524 2.7762057182735975 0.9724715960313098 1.364038299929986 0.6048193764192351 0.11867280434127275 0.20576045528769243 3.0352981684153604 0.03754621705421078 0.10104106490240235 4.46862992978931e-06 5.349825610008524 0.3915667038986762 RSEDESET(ph)EDEEEKSQEDQEQK ddPTM_A459_Selumetinib_30min_R2 1 RSEDESETEDEEEKSQEDQEQK 22 2 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 RS(0.003)EDES(0.44)ET(0.558)EDEEEKSQEDQEQK 83.881 0.002362 39833000.0 11259.0 10476.0 11305.0 10039.0 10859.0 5523.1 11921.0 8694.2 5677.0 8735.9 True False 10633.269853348063 11279.475514350828 10577.648607953337 8671.670881759062 9494.795339308288 6283.856891290079 12475.350121013367 8719.498682597705 6812.558628633129 8483.67186840594 1.2533806137584653 1.329551129429787 1.2468243435187045 1.022160099573541 1.119184651008 0.7407001341826767 1.4705130413486223 1.0277977293145917 0.8030200524378829 1.0 13.050473106028155 -5.7012178905296 4.447256272419654 1.037291638713394 1.2900985208669093 0.27760432851437966 0.18503949486386273 0.2875103478005465 11.35133214755738 0.051394569109017796 0.08985015997319902 1.989674845808106e-06 5.7012178905296 0.25280688215351543 RSEEHS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 RSEEHSPPR 9 1 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 RS(0.001)EEHS(0.999)PPR;RSEEHS(1)PPR 80.245 0.024076 6112000.0 725.74 929.01 957.72 1908.03 1451.98 1045.9 1127.99 5035.0 1103.12 2980.09 True False 685.4062761674055 1000.2620797620331 896.1013378866934 1648.153022464661 1269.5692915341053 1189.963231265104 1180.4437700697817 5049.65101641088 1323.7748237480675 2894.047058496303 0.23683314829149005 0.3456274412765603 0.30963606319252185 0.5694976581759569 0.4386830158158353 0.411176185878397 0.40788686092862636 1.7448406727133843 0.4574130264612484 1.0 11.498872665587452 -7.5916028811178915 23.773547908760506 1.0759612958854565 0.3923693170788323 0.5173901364554309 0.3004772705753866 24.24894423278859 8387.483916105086 0.1291444157139006 0.0745615593642868 2.560926527864894e-08 7.5916028811178915 -0.6835919788066243 RSELSQDAEPAGS(ph)QETK ddPTM_A459_Selumetinib_30min_R2 1 RSELSQDAEPAGSQETK 17 1 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2;X6RJY0 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 RSELSQDAEPAGS(0.592)QET(0.408)K 62.847 0.026186 8006100.0 23160.0 24423.0 36359.0 43780.0 35655.0 31439.0 25151.0 34499.0 33126.0 39409.0 True False 21872.85991682575 26296.165567677548 34019.70152468602 37817.08847528751 31175.700140255725 35769.43687517312 26320.571335761033 34599.386378383075 39752.125617773636 38271.159773121224 0.5715233101503131 0.6871013505617876 0.8889122181392289 0.9881354184057778 0.814600349847542 0.9346316413513781 0.6877390570809567 0.9040589985643204 1.038696654437228 1.0 15.223970000795678 -5.117453865702638 2.79869299893601 0.8974410451095005 0.5816258610062991 0.5843396113888022 0.09572046778835626 0.20905756836348505 3.0019061591822993 0.025822047013512126 0.10358902761524896 7.630379429620025e-06 5.117453865702638 -0.3158151841032014 RSEPQPEEGS(ph)PAGGQK ddPTM_A459_Selumetinib_30min_R1 2 RSEPQPEEGSPAGGQK 16 1 F8WE91;Q9Y6K1-3;Q9Y6K1 F8WE91 DNMT3A DNA (cytosine-5)-methyltransferase 3A 1 RSEPQPEEGS(1)PAGGQK;RSEPQPEEGS(1)PAGGQK 154.07 0.00053048 2442700.0 2329.0 2621.3 2649.5 3266.6 2745.8 2122.2 2688.2 2170.7 1311.6399999999999 1890.63 True False 2383.2611685548845 2314.39697739069 2289.7124526617426 2696.149631676355 2497.4428748103646 2100.8525948034294 2485.4269097177626 2113.125984572682 2225.7572816046986 2133.3107767957176 1.1171654849719543 1.0848850540505721 1.0733140607394034 1.2638335028363914 1.1706887257006136 0.9847850663178849 1.1650561825084536 0.9905382786031045 1.0433347573239367 1.0 11.05887843481435 -6.750220600383513 24.997521860832247 1.0441710775341946 1.1417607351790227 0.36721871517094573 0.0687251713858179 274.5248013821557 611691.1839703433 0.023655600911150716 0.02344691831856748 1.7773763603314038e-07 6.750220600383513 0.09758965764482808 RSEPQPEEGS(ph)PAGGQK ddPTM_A459_Selumetinib_30min_R2 2 RSEPQPEEGSPAGGQK 16 1 F8WE91;Q9Y6K1-3;Q9Y6K1 F8WE91 DNMT3A DNA (cytosine-5)-methyltransferase 3A 1 RSEPQPEEGS(1)PAGGQK;RSEPQPEEGS(1)PAGGQK 174.81 1.1656e-06 7938500.0 52131.0 47352.0 43564.0 50161.0 48198.0 33805.0 31422.0 37313.0 25685.0 49431.0 True False 49233.76771692756 50983.74613932227 40761.13966889687 43328.985267448545 42142.936344412985 38461.33189876357 32883.18526151179 37421.57465250033 30822.717698862412 48003.79859283802 1.0256223290686217 1.0620773279164797 0.8491232124071587 0.902615762451621 0.8779083651663463 0.8012143419104722 0.6850121495680517 0.7795544467200451 0.6420891388262144 1.0 15.55086095192942 -5.559628639131425 0.7124254906492641 0.7633301156897414 1.098208675329383 0.4637546220617824 0.09772425183730238 1.0405987972936204 0.785973016201735 0.04673612078655399 0.24033106623879333 2.7565848239644153e-06 5.559628639131425 0.3348785596396415 RSES(ph)PPAELPSLR ddPTM_A459_Selumetinib_30min_R1 3 RSESPPAELPSLR 13 1 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 RS(0.121)ES(0.879)PPAELPSLR;RS(0.006)ES(0.994)PPAELPSLR;RS(0.2)ES(0.8)PPAELPSLR 167.37 0.00022182 111546000.0 6207.4 8942.8 7896.9 9137.9 7892.900000000001 8200.3 7610.700000000001 6211.9 3328.0099999999998 5717.200000000001 True False 6352.020342502184 7895.772818605071 6824.544354566716 7542.137304627244 7178.988588604672 8117.812427276675 7036.618771590275 6047.140232905078 5647.389901766678 6451.058310243928 0.9846477952951569 1.2239499999662096 1.0578953136619014 1.1691317830208947 1.1128388929929267 1.2583690980417948 1.0907696742434507 0.937387315706409 0.8754206876101138 1.0 12.655320141894846 -7.709504798550818 4.120212597497377 0.9270683328103485 1.1381177736712658 0.5558556742839531 0.07858504368600765 0.14220094639990122 4.9498298036826744 0.03896565890279439 0.020405477052420094 1.9520691653722073e-08 7.709504798550818 0.21104944086091726 RSES(ph)PPAELPSLR ddPTM_A459_Selumetinib_30min_R2 2 RSESPPAELPSLR 13 1 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 RS(0.017)ES(0.983)PPAELPSLR;RS(0.005)ES(0.99)PPAELPS(0.005)LR 127.91 0.00096468 32960000.0 90570.0 75807.0 102875.0 95343.0 112733.0 78981.0 69116.0 86729.0 71747.0 91945.0 True False 85536.48198043648 81621.15314207632 96256.13450183078 82357.11892415126 98570.47269419298 89859.91583186651 72330.03095075575 86981.36703124123 86098.40477867571 89290.30894820049 0.9579593013846364 0.9141098748961297 1.078013231622609 0.9223522675000336 1.1039324855665595 1.0063792688184836 0.8100546610575196 0.9741411812305552 0.9642525128748689 1.0 16.446215981647732 RSESPPAELPS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 RSESPPAELPSLR 13 1 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 RS(0.101)ES(0.178)PPAELPS(0.72)LR 127.51 0.0034466 29177000.0 2884.0 4534.0 3354.3 4374.0 3867.1 3628.2 3793.5 3174.0 1873.4 2663.6 True False 2951.191588712875 4003.157172200586 2898.804483851022 3610.163010148892 3517.3214877919577 3591.703602142022 3507.3532408356286 3089.8152093949857 3179.022972277639 3005.499005661112 0.9819306488386972 1.3319442677107198 0.9645002305410443 1.2011858940391744 1.1702953423597162 1.1950440161107172 1.1669786728357694 1.0280539782495544 1.0577354929380047 1.0 11.553388827420664 -7.765322292036428 24.627889660072714 1.0321710044835835 1.1499464270525168 0.21401865942916598 0.1013961198496918 123.05005175166023 780433.2613540092 0.04913869343032134 0.02501942792457431 1.716633991956995e-08 7.765322292036428 0.11777542256893336 RSET(ph)PPHWR ddPTM_A459_Selumetinib_30min_R1 1 RSETPPHWR 9 1 Q13427;E9PG73;C9JM79 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 RSET(1)PPHWR 80.834 0.02521 4894900.0 419.76 545.54 477.28 532.82 658.78 438.25 409.02 443.13 220.81 348.34 True False 429.539591289222 481.6679231853348 412.4679975113781 439.77298927012674 599.1934653170554 433.84160289916275 378.16729209610884 431.3767529109008 374.69844267568317 393.0528321189336 1.0928291470985965 1.2254533839348782 1.0493958160478785 1.1188648276602573 1.5244603685637501 1.103774270141595 0.9621283990180726 1.097503230253715 0.9533029965862284 1.0 8.61857943486208 -6.998219428872571 24.999532857440677 1.0144435245652703 1.2027479474078313 0.35335742003242177 0.126582930144833 71.65493031164563 1006028.1950879309 0.04623449695805472 0.04049788833881764 1.0041083326907454e-07 6.998219428872571 0.188304422842561 RSGPTDDGEEEMEEDTVTNGS ddPTM_A459_Selumetinib_30min_R2 1 RSGPTDDGEEEMEEDTVTNGS 21 1 P09661 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 72.898 0.045415 0.0 3814.0 3871.1 7356.7 7353.2 6271.6 4402.9 3686.2 4479.9 4726.8 6244.1 False True 3602.0331486516984 4168.000922451646 6883.377931369336 6351.681475022483 5483.705539184628 5009.359509453224 3857.6156040667283 4492.93576731263 5672.292077826859 6063.816608879855 0.5940207926764935 0.687356031900441 1.1351560205975415 1.0474725547802812 0.9043323525243635 0.8261066969138736 0.6361695699071167 0.7409418947026156 0.9354326563109366 1.0 12.566010406663768 -9.296534754662542 15.548244169807026 0.9999971486460376 0.8381912009490612 0.08118705428761064 0.16691434344026385 0.0 0.0 0.17739527089335758 0.043024672904610095 5.052022142283443e-10 9.296534754662542 -0.16180594769697643 RSHS(ph)PSIDGTPK ddPTM_A459_Selumetinib_30min_R1 1 RSHSPSIDGTPK 12 1 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 RS(0.383)HS(0.538)PS(0.074)IDGT(0.006)PK 64.53699999999999 0.041597 15398000.0 4243.9 4580.4 5089.8 5881.3 5492.9 4490.4 4426.3 4325.6 2313.8 3367.8 True False 4342.774612808102 4044.1246386298085 4398.633116270138 4854.24136067414 4996.068164850263 4445.230652956989 4092.420627365426 4210.871036470999 3926.3496067342767 3800.089935149984 1.1428083774119149 1.0642181389504912 1.1575076356966616 1.277401704568487 1.3147236644685032 1.1697698551393738 1.0769273088806264 1.108097731456664 1.033225443012919 1.0 11.891817847286603 -7.266908871926876 3.6095102731045996 1.0603636565339243 1.1918415572022487 0.4667636158022289 0.0700571531587434 0.26697489309782796 7.644542410619137 0.0347280503239441 0.024066101358751493 5.408678014075297e-08 7.266908871926876 0.13147790066832443 RSHS(ph)PSIDGTPK ddPTM_A459_Selumetinib_30min_R2 2 RSHSPSIDGTPK 12 1 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 RS(0.098)HS(0.899)PS(0.003)IDGTPK;RS(0.168)HS(0.824)PS(0.009)IDGTPK 77.051 0.023917 12364300.0 60743.0 57869.0 68485.0 68513.0 74043.0 43498.0 47288.0 54900.0 40740.0 61857.0 True False 57367.14723349509 62307.36622183736 64078.749660830086 59181.411208482685 64741.05638718151 49489.45466447027 49486.98569939436 55059.749910815764 48889.13837070877 60071.02768621275 0.9549886100360783 1.0372282383332336 1.0667163877327368 0.985190590006599 1.0777417813686014 0.823848976298251 0.8238078755351876 0.9165774589112423 0.8138555349192004 1.0 15.874381725037276 -6.763455064969219 24.999999999600348 0.8671659188201977 1.0252628968917514 0.5922081513583389 0.0615179326903986 34.57666588564023 428840.8375425049 0.02003132666180694 0.01854919044608753 1.7240304615968733e-07 6.763455064969219 0.15809697807155376 RSIS(ph)SPNVNR ddPTM_A459_Selumetinib_30min_R1 2 RSISSPNVNR 10 1 Q9NQT8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 RS(0.004)IS(0.768)S(0.228)PNVNR;RS(0.01)IS(0.759)S(0.231)PNVNR 105.36 0.022553 37804000.0 8485.900000000001 9009.2 10235.5 10905.0 11724.5 8773.8 10139.8 8744.2 4697.1 6800.299999999999 True False 8683.604959312968 7954.3986757365465 8845.575319577001 9000.646462202485 10664.021045128598 8685.543537973012 9374.94672240018 8512.275410835424 7970.6356373893905 7673.184745531339 1.131681986983315 1.0366489195205393 1.1527906094960676 1.1730000984850815 1.389777699714456 1.131934630276072 1.2217803993133232 1.109353637782897 1.0387649850384848 1.0 12.905609775422596 -8.16443307086331 2.3850886919485195 1.0078731017773759 1.1767480213448376 0.35107844561082424 0.08521883400061185 0.3712862328018919 3.7696314028725104 0.08165662900915094 0.02481167625545726 6.848050102818665e-09 8.16443307086331 0.1688749195674617 RSLS(ph)GSSPCPK ddPTM_A459_Selumetinib_30min_R1 2 RSLSGSSPCPK 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RS(0.018)LS(0.936)GS(0.023)S(0.023)PCPK;RS(0.008)LS(0.378)GS(0.307)S(0.307)PCPK 135.91 0.0026195 17212000.0 5895.200000000001 7019.6 8076.799999999999 8761.0 6980.8 6125.9 6763.3 6194.799999999999 3190.6 5174.1 True False 6032.546689937637 6197.741968676495 6980.014922686675 7231.055814338013 6349.387872560341 6064.279007872172 6253.138835835928 6030.493780453699 5414.215167796001 5838.246135001941 1.0332806377879153 1.061575998229892 1.195567086635746 1.2385664542277146 1.0875505632580236 1.0387158861828554 1.0710646127689938 1.032929006589698 0.9273701455196015 1.0 12.511319319459323 -7.453163515541664 1.0472564363379446 0.9734406678215405 1.1271075310206278 0.45756903584090813 0.0631367080258663 0.539085582367203 1.106968393684924 0.05483727002217131 0.026795116321441194 3.522382254051298e-08 7.453163515541664 0.1536668631990873 RSNS(ph)APLIHGLSDTSPVFQAEAPSAR ddPTM_A459_Selumetinib_30min_R2 1 RSNSAPLIHGLSDTSPVFQAEAPSAR 26 1 Q96E09 Q96E09 FAM122A Protein FAM122A 1 RS(0.141)NS(0.858)APLIHGLSDTSPVFQAEAPSAR 73.839 0.00013119 2386900.0 6323.8 5969.7 6972.3 7658.1 7912.8 5865.3 5642.4 5928.1 5573.8 7230.1 True False 5972.348512177143 6427.556794389094 6523.70980886626 6615.053569040642 6918.723322670465 6673.191835107769 5904.78278020349 5945.349789550215 6688.71574498421 7021.348226944188 0.850598534517695 0.9154305678393161 0.9291249483726989 0.9421343814932289 0.9853838748689455 0.950414595518795 0.84097563450052 0.8467533011302779 0.9526255540661674 1.0 12.777532365557873 -7.440462138527576 0.00630447499903665 1.8448417977256895 2.7522184589037294e-06 0.12760949027079582 0.0508736003851241 12502.428690802682 56.39378108205117 8188.67001558976 8308.616879783522 3.626919040791896e-08 7.440462138527576 -1.8448390455072305 RSNS(ph)PDKFK ddPTM_A459_Selumetinib_30min_R1 1 RSNSPDKFK 9 2 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 RSNS(1)PDKFK 158.56 0.028615 48502000.0 4972.9 6757.0 5812.6 4880.1 3636.0 5738.1 3717.0 5895.4 8019.3 4982.6 True False 5088.758894421035 5965.887298755923 5023.280846326343 4027.8821458225 3307.12444198794 5680.379923777946 3436.6236974261333 5739.034841041964 13608.166393501686 5622.165244633977 0.9051243912259522 1.0611369533206105 0.8934779800577307 0.7164289860862547 0.5882296763056536 1.0103544945071707 0.6112633741432959 1.0207872930308357 2.420449382289123 1.0 12.456910142170896 -8.024130052583708 23.269875639065496 1.7136900650048221 0.830704463513164 0.49810879140766173 0.34981733124329706 233.77129750574164 225434.97065484384 0.2131173827920786 0.08174417073509702 9.459538463136426e-09 8.024130052583708 -0.8829856014916582 RSNS(ph)TTQVSQPR ddPTM_A459_Selumetinib_30min_R1 2 RSNSTTQVSQPR 12 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 RS(0.005)NS(0.86)T(0.132)T(0.004)QVSQPR;RS(0.002)NS(0.794)T(0.197)T(0.006)QVSQPR 131.72 0.0010194 5522000.0 718.8399999999999 742.73 818.72 961.48 1046.11 661.3900000000001 793.48 757.9300000000001 518.24 481.5 True False 735.5875733808467 655.7708263141906 707.5423209070473 793.5755672148968 951.4895352057209 654.7370170940721 733.6271647655867 737.8272342963901 879.4154292479789 543.3052152071726 1.3539122261146586 1.2070026349077703 1.302292525642788 1.4606441186328227 1.7512983652161334 1.2050998200788638 1.3503039253651203 1.3580345147525272 1.6186397712244323 1.0 9.085619085334327 -10.364675194676597 14.0728578612449 1.0000000015569945 1.3957752597244615 0.3515615983781186 0.16317138421877686 0.0 0.0 0.16363833096147953 0.039688124879644765 4.3184192716173055e-11 10.364675194676597 0.39577525816746695 RSNS(ph)TTQVSQPR ddPTM_A459_Selumetinib_30min_R2 4 RSNSTTQVSQPR 12 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 RS(0.027)NS(0.969)T(0.002)T(0.002)QVSQPR;RS(0.012)NS(0.972)T(0.008)T(0.008)QVSQPR;RS(0.092)NS(0.702)T(0.201)T(0.005)QVSQPR;RS(0.001)NS(0.856)T(0.071)T(0.071)QVSQPR 147.39 0.001133 11364470.0 9089.35 10713.300000000001 12074.7 11695.699999999999 15044.2 5210.34 6590.79 7501.53 2848.42 11027.1 True False 8584.200314550953 11534.975661311066 11297.826947939331 10102.725483792146 13154.213099145563 5928.017040242679 6897.274794402624 7523.358210354854 3418.1835915045253 10708.718971153417 0.8016085152364741 1.0771573791770401 1.0550119933460596 0.9434112064203324 1.2283647684265213 0.5535692043288519 0.6440802875658741 0.7025451158650143 0.31919631103517127 1.0 13.38649828778877 -6.7737453217048715 24.99998501025877 0.6252998181955605 1.021791241164224 0.5049942926051598 0.18628744775076722 174.50305605783873 354507.3949944343 0.06176509732888297 0.054854829240374686 1.6836611015593584e-07 6.7737453217048715 0.3964914229686636 RSNT(ph)LDIMDGR ddPTM_A459_Selumetinib_30min_R1 1 RSNTLDIMDGR 11 1 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 RS(0.043)NT(0.957)LDIMDGR 108.23 0.012592 16385000.0 2872.2 3540.5 4109.2 3803.0 3632.5 3393.1 2903.9 3119.7 1597.6 2684.1 True False 2939.1166716716766 3125.9766140662036 3551.193210219901 3138.8774411514064 3303.9410163699627 3358.968494688303 2684.8564850566977 3036.9554217862415 2711.010515912647 3028.6303803480237 0.9704441620683799 1.032141998690178 1.1725409720719466 1.0364016228321378 1.0909026858504611 1.1090717825733227 0.8864919610124816 1.0027487809315514 0.895127557824049 1.0 11.564449804367868 -7.255264074706345 24.995118514200936 0.9463211390897828 1.0712044084364505 0.4912733095945456 0.06103000201338505 426.6572071353695 1726938.4952779724 0.02359466624470652 0.01779889108071488 5.5556633994154435e-08 7.255264074706345 0.12488326934666771 RSNT(ph)LDIMDGR ddPTM_A459_Selumetinib_30min_R2 1 RSNTLDIMDGR 11 1 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 RS(0.009)NT(0.991)LDIMDGR 91.712 0.032489 2499900.0 22761.0 14513.0 20162.0 22219.0 24153.0 15552.0 17464.0 17344.0 16102.0 18753.0 True False 21496.034739502193 15626.100433349891 18864.798870725794 19192.733870087097 21118.684209440376 17694.146833000177 18276.110604259506 17394.468168546224 19322.84992747061 18211.552163854496 1.1803516002423229 0.8580323243596942 1.0358699083413567 1.0538768852541853 1.159631206578637 0.9715891689956421 1.0035449169749047 0.9551337531278643 1.061021584191037 1.0 14.152566267469116 RSNVSSPATPTASSSS(ph)STTPTR ddPTM_A459_Selumetinib_30min_R1 1 RSNVSSPATPTASSSSSTTPTR 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 RSNVSSPATPTASS(0.031)S(0.083)S(0.352)S(0.352)T(0.083)T(0.083)PT(0.013)R 101.71 5.8496e-05 2662700.0 376.56 251.38 475.55 549.45 722.98 316.93 510.5 372.23 207.12 391.61 True False 385.33311534178927 221.9483127366085 410.9729220091681 453.4988719538891 657.5865866524862 313.74197194941615 471.99257399409214 362.35725122655805 351.4675125537227 441.87695810442557 0.8720371322252253 0.5022853277725269 0.9300618972579372 1.0263012443539021 1.488166727392659 0.7100211183115636 1.0681538499288519 0.8200410647819405 0.7953967866110433 1.0 8.787500892774634 -5.432767285601572 6.689940620690182 0.9911611015963712 0.6891730847218834 0.22913252259704175 0.2166598144732635 0.34778347904687823 21.76010063890833 0.057639911603164326 0.12082854981656484 3.691753662441623e-06 5.432767285601572 -0.30198801687448773 RSNVSSPATPTASSSS(ph)STTPTR ddPTM_A459_Selumetinib_30min_R2 1 RSNVSSPATPTASSSSSTTPTR 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 RSNVSSPATPTAS(0.002)S(0.002)S(0.017)S(0.225)S(0.225)T(0.225)T(0.225)PT(0.079)R 132.77 1.0845e-05 3754200.0 4525.6 5672.1 7751.1 6978.0 6076.9 6058.0 6926.4 5019.2 5129.4 6837.3 True False 4274.0852694121995 6107.131831323912 7252.402664759588 6027.5843622785815 5313.465493824712 6892.434510951332 7248.491324401226 5033.805041026709 6155.423327410739 6639.889383561154 0.6436982640093156 0.9197640922217427 1.092247512844849 0.907783852122823 0.800234038081965 1.0380345383486993 1.091658445748634 0.758115798357915 0.9270370290580681 1.0 12.696943492029911 -4.768693310327033 5.0704715969465335 0.9480287872871532 0.6267677412259843 0.428642043328891 0.10596215649993343 0.16324342874207975 11.310408114798905 0.027237480615723696 0.18471674170310512 1.703360961629634e-05 4.768693310327033 -0.3212610460611689 RSNVSSPATPTASSSSST(ph)TPTR ddPTM_A459_Selumetinib_30min_R2 1 RSNVSSPATPTASSSSSTTPTR 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 RSNVSSPATPTAS(0.001)S(0.001)S(0.003)S(0.045)S(0.144)T(0.466)T(0.309)PT(0.03)R 113.29 4.7845e-05 2922900.0 6661.1 6994.7 8645.9 8755.4 9114.5 5336.6 5412.3 6122.4 5444.7 6084.8 True False 6290.902728496027 7531.170998494625 8089.632206944162 7562.899416092559 7969.455025336167 6071.668209168521 5663.982674268993 6140.215170382115 6533.792137628822 5909.116013790958 1.0646097849177505 1.274500446584234 1.3690088649578411 1.2798698482889703 1.3486712744743372 1.0275087161934529 0.9585160726325457 1.0391089218847298 1.1057139718326678 1.0 12.528726608312361 -6.772648059886673 24.948159767924633 1.024385431072326 1.274075540710181 0.6738364099067794 0.08382173033227153 128.14997540887728 285233.16750923294 0.03042836449371985 0.02707637346468753 1.6879203147675488e-07 6.772648059886673 0.24969010963785498 RSPQQTVPYVVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 RSPQQTVPYVVPLSPK 16 1 Q9UQR0;H0Y6S1;B4DRC2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 RSPQQTVPYVVPLS(1)PK;RSPQQTVPYVVPLS(1)PK 135.21 0.00021202 123359000.0 8807.9 9448.5 11108.400000000001 11161.4 7551.4 8960.8 7412.5 7880.4 5537.6 7753.900000000001 True False 9013.106932810037 8342.26522751152 9599.94029407348 9212.271015426586 6868.377203307957 8870.662487755424 6853.369157162016 7671.38619285326 9396.902749698223 8749.18859438193 1.0301648930733502 0.9534901594038439 1.0972377827399717 1.0529286134421667 0.7850301921389957 1.0138840181650095 0.7833148277958865 0.876811159126144 1.0740313399727384 1.0 13.094933511305193 -6.20830690646058 24.999040646556818 0.9136609557100276 1.032299515906023 0.24759493403274802 0.09432374414709836 446.1438284831624 209911.98873566845 0.027218407651699757 0.035138787387635845 6.190034841835891e-07 6.20830690646058 0.1186385601959955 RSPQQTVPYVVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 RSPQQTVPYVVPLSPK 16 1 Q9UQR0;H0Y6S1;B4DRC2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 RSPQQTVPYVVPLS(1)PK;RSPQQTVPYVVPLS(1)PK 123.61 0.0006945 33847700.0 233794.0 250171.0 216776.0 240286.0 207785.0 176208.0 203672.0 184846.0 152645.0 226296.0 True False 220800.66543153534 269358.3112734498 202828.86816786308 207558.63228353029 181681.19067853127 200479.05254303597 213143.15156841138 185383.87125709717 183178.26525765407 219762.24649238095 1.0047251925921243 1.225680550561665 0.9229468273336706 0.9444690141112397 0.826717025232221 0.9122542918216232 0.9698806549822968 0.8435655997151646 0.8335292716622497 1.0 17.745584037810197 -5.371331043632419 6.555085065461804 0.9005287866242188 1.1139165021290474 0.5605891869636495 0.07385785476351989 0.1492206499060118 7.670130588101297 0.018594760494812398 0.03916870274920591 4.252741217453296e-06 5.371331043632419 0.2133877155048286 RSPS(ph)APVCK ddPTM_A459_Selumetinib_30min_R1 1 RSPSAPVCK 9 1 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 RS(0.048)PS(0.952)APVCK 95.477 0.040118 3378200.0 1120.3 1223.8 1410.6 1668.1 1618.9 1122.0 1121.8 1277.4 769.28 1066.9 True False 1146.4008102756707 1080.5169270708152 1219.048267871165 1376.7976491150823 1472.4707808400099 1110.7136986944909 1037.1817228336379 1243.5192024200228 1305.4119740118188 1203.8470074860493 0.9522811479754878 0.8975533604782722 1.0126272360944437 1.1436649678518533 1.2231378004709403 0.9226369229541507 0.8615560917491895 1.0329545155549453 1.0843670050215632 1.0 10.233436341572059 -5.374566702424515 5.286091467714933 1.0380139546448257 0.9260295213574405 0.17246800628814674 0.09755620305229931 0.4190060100783595 16.5147027316492 0.02892580557133335 0.06200607709261661 4.221174418949636e-06 5.374566702424515 -0.11198443328738517 RSPS(ph)APVCK ddPTM_A459_Selumetinib_30min_R2 1 RSPSAPVCK 9 1 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 RS(0.395)PS(0.605)APVCK 84.352 0.018795 8294100.0 76470.0 74373.0 76939.0 90494.0 84797.0 56417.0 55884.0 59074.0 44310.0 67051.0 True False 72220.10353366421 80077.16995311316 71988.82850484949 78168.56108914257 74144.04276520172 64187.92964746471 58482.71673204525 59245.895559772835 53173.238124843025 65115.063410580115 1.109115153252383 1.2297794973828122 1.1055633632870348 1.2004681711857395 1.1386619144895826 0.9857616085348885 0.8981442030284928 0.9098646681214222 0.8166042592873104 1.0 15.990703707792443 -6.874987089641368 2.43830003786494 0.8990001855825667 1.1643562581113802 0.8289913117971658 0.054246506668032664 0.10463721267657146 1.2669191325646016 0.020327816996345054 0.01752297027044887 1.3335610746099767e-07 6.874987089641368 0.26535607252881355 RSPS(ph)PLGTSVR ddPTM_A459_Selumetinib_30min_R2 2 RSPSPLGTSVR 11 1 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 RS(0.033)PS(0.966)PLGT(0.001)S(0.001)VR;RS(0.001)PS(0.996)PLGT(0.003)SVR 120.9 0.008256900000000001 167531000.0 59541.0 68455.0 76196.0 74883.0 87802.0 64693.0 49109.0 50988.0 46194.0 69238.0 True False 56231.94958150786 73705.27838248228 71293.63231593225 64683.80621961975 76771.52780016085 73603.87352541667 51392.66580763738 51136.36663848222 55434.090768201306 67238.91903807168 0.8363006185401121 1.0961698884651798 1.0603030705411063 0.9619994959019912 1.141772189357947 1.0946617610515281 0.7643291495887685 0.7605173814517757 0.82443459176989 1.0 16.03700891092084 -7.262026210380845 24.999014588643714 0.8173633901247598 1.03790298986473 0.46177937660916946 0.10186376536511701 43.13358633043236 1837429.0668910532 0.039962128482351596 0.028758581343744677 5.469829505839467e-08 7.262026210380845 0.22053959973997028 RSPS(ph)PSPTPEAK ddPTM_A459_Selumetinib_30min_R1 2 RSPSPSPTPEAK 12 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 RS(0.01)PS(0.918)PS(0.072)PTPEAK;RSPS(0.999)PS(0.001)PTPEAK 127.03 0.0047615 16807300.0 6605.1 7729.5 8476.5 8642.2 7191.0 6965.0 7067.4 7448.1 4121.6 6185.1 True False 6758.985978712697 6824.526546652941 7325.437858081623 7133.002004185824 6540.575319674164 6894.938423714015 6534.300328003616 7250.552193161557 6994.054170246347 6979.017832975882 0.9684723754073913 0.9778634630229817 1.0496373606424825 1.0220638741575307 0.9371770464276398 0.9879525441438777 0.9362779239693336 1.0389072455013189 1.0021545062113781 1.0 12.768808302874055 RSPS(ph)PSPTPEAK ddPTM_A459_Selumetinib_30min_R2 2 RSPSPSPTPEAK 12 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 RS(0.053)PS(0.909)PS(0.037)PT(0.001)PEAK;RS(0.041)PS(0.882)PS(0.072)PT(0.005)PEAK 68.515 0.035447 35223000.0 70816.0 75500.0 72553.0 79009.0 76902.0 48234.0 49827.0 50210.0 43517.0 68889.0 True False 66880.33021890902 81290.6072292369 67885.01896973375 68247.83790187277 67240.88324739714 54877.79567534277 52144.05423032744 50356.10278728702 52221.61596657177 66899.99557488269 0.999706048471234 1.2151063169839298 1.014723818535212 1.0201471213175404 1.0050954812415926 0.8202959537406367 0.7794328502153848 0.7527071168625458 0.7805922185468447 1.0 16.029718494988757 -6.6329468432486465 1.9680726734110592 0.8026099101039027 1.0740878180786455 0.6249741834628748 0.08653586154193924 0.1936165187430965 1.5346646506956851 0.03232096767228548 0.03243529731480291 2.3283762286862423e-07 6.6329468432486465 0.2714779079747428 RSPT(ph)DSDVSLDSEDSGAK ddPTM_A459_Selumetinib_30min_R1 2 RSPTDSDVSLDSEDSGAK 18 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 RS(0.099)PT(0.899)DS(0.001)DVSLDSEDSGAK;RS(0.04)PT(0.916)DS(0.04)DVS(0.004)LDSEDSGAK 206.21 1.5567999999999998e-28 6793900.0 4659.46 5094.2 5297.86 6035.18 5209.99 4639.9800000000005 5589.96 5079.29 3032.04 4026.34 True False 4768.016352269102 4497.768695770669 4578.439711061914 4981.249107359488 4738.747324398445 4593.30601396476 5168.304816697387 4944.570729340849 5145.150428560202 4543.159958872789 1.049493391258912 0.9900088785090055 1.0077654655588835 1.0964282905406206 1.043050952926206 1.0110377040531087 1.137601331118375 1.088354971892219 1.1325047929496135 1.0 12.149480386404944 -6.410327366615538 0.8163730887996087 1.0893515219056913 1.016991217802302 0.17295618811704838 0.04746495673566487 0.9699080995701868 1.4216682320997613 0.027240954179836237 0.03853523083095929 3.8875199735296967e-07 6.410327366615538 -0.07236030410338934 RSPT(ph)DSDVSLDSEDSGAK ddPTM_A459_Selumetinib_30min_R2 3 RSPTDSDVSLDSEDSGAK 18 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 RS(0.061)PT(0.939)DSDVSLDSEDSGAK;RS(0.237)PT(0.744)DS(0.019)DVSLDSEDSGAK;RS(0.051)PT(0.918)DS(0.032)DVSLDSEDSGAK 183.75 7.2962e-10 48569000.0 186632.0 183333.0 203644.0 207535.0 195462.0 170848.0 171224.0 152791.0 137929.0 182183.0 True False 176259.74058709096 197394.05159149275 190541.76675082222 179268.37498215595 170906.31610754915 194380.76119627137 179186.25527391955 153235.59651408842 165518.65405825953 176922.90342171933 0.9962516846501912 1.1157066031240608 1.0769762595215868 1.0132570261683185 0.9659931687881651 1.0986749450575028 1.0127928708404996 0.8661150905308791 0.9355411360377902 1.0 17.43276129755894 -7.590117863692316 6.715063810763575 0.926677522519638 1.0451528453013956 0.467450468293373 0.052613124037627405 0.1772239890171501 14.07693809101977 0.02513324370789746 0.014396485010772805 2.5696982946722547e-08 7.590117863692316 0.11847532278175765 RSPTDSDVSLDS(ph)EDSGAK ddPTM_A459_Selumetinib_30min_R1 1 RSPTDSDVSLDSEDSGAK 18 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 RSPTDS(0.018)DVS(0.221)LDS(0.761)EDSGAK 187.78 3.6046e-10 5441200.0 1424.8 1504.3 1806.9 1647.9 1688.9 1596.1 1710.5 1526.0 880.12 1137.4 True False 1457.9950678218115 1328.1758566699023 1561.5329045912447 1360.1251999141207 1536.1392931995135 1580.0446831428483 1581.4756078685493 1485.5255228534177 1493.499358578518 1283.3963692142033 1.1360442516402873 1.0348913932825885 1.216719122828233 1.059785762637693 1.1969328650509268 1.231143176842768 1.2322581283573786 1.1574955006012475 1.1637085739092097 1.0 10.32575109155574 -5.261435518698579 24.999999936749365 1.1661337431780165 1.0854678250595051 0.11930412725432427 0.07497526039902083 0.5941392277718829 3796377.386751899 0.01873785453688865 0.04354299749638895 5.477274180322926e-06 5.261435518698579 -0.08066591811851143 RSQANGAGALSYVS(ph)PNTSK ddPTM_A459_Selumetinib_30min_R2 1 RSQANGAGALSYVSPNTSK 19 1 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;A0A494C002;A0A494C1N1;A0A494C0Q2;F5H1Z4;A0A494C1K5;A0A494C0P9;A0A494BZU6;A0A494C1G3;A0A494C156;A0A494BZW7 O95453 PARN Poly(A)-specific ribonuclease PARN 1 RSQANGAGALSYVS(0.998)PNT(0.001)SK 104.57 0.00046193 7696900.0 15794.0 17704.0 23641.0 23278.0 18171.0 13104.0 18189.0 16875.0 14462.0 16167.0 True False 14916.232708391442 19061.839872667704 22119.96379837459 20107.496243210215 15888.196529198896 14908.957053731636 19034.824540819744 16924.10345619337 17354.80410204198 15700.21670308941 0.9500654029479925 1.2141131701014554 1.4088954449922932 1.280714567414446 1.011973072070559 0.9496019918500822 1.2123924720780552 1.0779534942892304 1.1053862777974899 1.0 13.938496851680036 -6.26136185663644 24.999724377995786 1.0655934933358127 1.2274553136678565 0.26259717739794475 0.12521905391825444 10.090179678760547 3253937.9718076712 0.04011889159408442 0.048503223153205224 5.478203276930079e-07 6.26136185663644 0.16186182033204388 RSQANGAGALSYVSPNT(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 RSQANGAGALSYVSPNTSK 19 1 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;A0A494C002;A0A494C1N1;A0A494C0Q2;F5H1Z4;A0A494C1K5;A0A494C0P9;A0A494BZU6;A0A494C1G3;A0A494C156;A0A494BZW7 O95453 PARN Poly(A)-specific ribonuclease PARN 1 RSQANGAGALSYVS(0.445)PNT(0.499)S(0.056)K 151.23 2.8406e-05 9205300.0 25814.0 24728.0 22595.0 26980.0 22204.0 18662.0 14953.0 17897.0 14245.0 23398.0 True False 24379.361221629526 26624.558086947985 21141.2622995759 23305.277456904012 19414.535013721455 21232.52110323105 15648.344128807392 17949.077306992163 17094.39803855538 22722.438944695128 1.0729200892988306 1.1717297668507483 0.9304134274948344 1.0256503500186522 0.8544212644151059 0.9344296690557543 0.6886736132021037 0.7899274083507936 0.7523135205759375 1.0 14.471830076388969 -5.999342283131072 0.8522033540011202 0.8000497752311699 1.1261740298905063 0.5558685861510604 0.0959845218763312 0.4755046828702782 0.6935603127267913 0.04388251123733313 0.10304149018261928 1.0015155964149105e-06 5.999342283131072 0.32612425465933637 RSQEDEISS(ph)PVNK ddPTM_A459_Selumetinib_30min_R1 1 RSQEDEISSPVNK 13 1 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 RSQEDEIS(0.093)S(0.907)PVNK 159.18 0.00010982 0.0 1025.4 2100.7 1735.7 2223.0 1700.1 1631.3 1502.1 1289.9 676.26 1062.3 True False 1049.2898249189257 1854.7490674110659 1500.0014735176396 1834.7947808781416 1546.3262551770335 1614.8906031018912 1388.7953876523522 1255.6876618143012 1147.5638279238158 1198.6565526782556 0.8753882190644287 1.547356549519418 1.2514022220677512 1.530709340201337 1.2900494739063924 1.3472504692804708 1.1586266178992257 1.0475791910607057 0.9573750090129828 1.0 10.22720263171558 -7.587045647466424 1.9813003755688365 0.9851422050091805 1.3262103644530836 0.3802677774967236 0.17455220308103592 0.3317778714535838 2.5773100433223646 0.10429280918569893 0.05025161641441768 2.587940889699578e-08 7.587045647466424 0.3410681594439031 RSQS(ph)FNSIDK ddPTM_A459_Selumetinib_30min_R1 1 RSQSFNSIDK 10 1 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 RSQS(0.928)FNS(0.072)IDK 92.781 0.046947 3955000.0 1193.8 1374.2 1833.3 1616.0 1465.9 1325.7 1369.1 1190.0 930.84 1020.7 True False 1221.6132172695673 1213.3080251517522 1584.3479295960628 1333.7959360769585 1333.309603825666 1312.3646616392919 1265.827684731267 1158.4373343352343 1579.5674941362856 1151.7167874599413 1.0606889042259942 1.0534777632508487 1.375640215412914 1.1580936829258037 1.1576714157012675 1.1394855713909078 1.0990789563144183 1.005835242612131 1.3714895114275008 1.0 10.169570279602073 -6.837377558507762 2.879739076770505 1.1197993506520272 1.1677542303608295 0.022763533275648618 0.12611648231825856 1.2823376948645844 21.55782607576234 0.04795578503024544 0.04263286050105133 1.4541943116642534e-07 6.837377558507762 0.0479548797088023 RSQS(ph)FNSIDK ddPTM_A459_Selumetinib_30min_R2 1 RSQSFNSIDK 10 1 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 RS(0.015)QS(0.984)FNS(0.001)IDK 71.529 0.036361 7056000.0 45720.0 40045.0 40345.0 42810.0 47489.0 32432.0 32835.0 31689.0 29929.0 37984.0 True False 43179.0654316612 43116.32273503044 37749.24662431467 36979.20414863087 41523.00726295342 36899.21361161662 34361.89256131816 31781.209743603653 35915.63628613016 36887.303225715834 1.1705671506384097 1.1688662212902587 1.0233669399284775 1.0024913971713436 1.1256720777030353 1.0003228857861446 0.9315371294847844 0.8615758530552462 0.9736584988704655 1.0 15.170836699211039 -5.125202840159553 0.43207367557802856 0.9325271888212223 1.3087800994146637 0.6115472079167892 0.05972820500578061 2.7775013213832316 0.5057023486386103 0.0512037668353085 0.5223605917197359 7.4954404797593695e-06 5.125202840159553 0.37625291059344135 RSQS(ph)IEQESQEK ddPTM_A459_Selumetinib_30min_R1 2 RSQSIEQESQEK 12 1 A0A0A0MRN0;Q5VTL8 A0A0A0MRN0 PRPF38B Pre-mRNA-splicing factor 38B 1 RS(0.092)QS(0.908)IEQESQEK;RS(0.004)QS(0.996)IEQESQEK 116.35 0.0025841 18822500.0 7187.7 7897.9 9265.3 8706.0 7039.5 6813.2 8390.5 7744.0 4199.6 6535.0 True False 7355.159425170435 6973.210196365903 8007.12315064987 7185.660531860143 6402.778467924667 6744.665393890646 7757.597829769696 7538.603963942901 7126.414473351751 7373.830906290502 0.9974678723505662 0.9456699353408233 1.08588374922174 0.9744813277085276 0.8683109972677235 0.9146758963698063 1.0520444431607197 1.0223456517712977 0.9664466901827539 1.0 12.848198618173665 -9.82140524912683 9.302884536018084 1.0000009455404364 0.980746814440073 0.00896243812194042 0.060521484189736394 0.0 0.0 0.06282170307371365 0.015236501020830063 1.508671724486649e-10 9.82140524912683 -0.019254131100363447 RSQS(ph)IEQESQEK ddPTM_A459_Selumetinib_30min_R2 2 RSQSIEQESQEK 12 1 A0A0A0MRN0;Q5VTL8 A0A0A0MRN0 PRPF38B Pre-mRNA-splicing factor 38B 1 RSQS(1)IEQESQEK;RSQS(1)IEQESQEK 128.82 0.0012305 43568000.0 204578.0 191829.0 194810.0 210692.0 205682.0 170981.0 152223.0 160184.0 133201.0 184811.0 True False 193208.37375062073 206541.66747254727 182276.13669309017 181995.38613602772 179842.38833958993 194532.08073901778 159301.67112415226 160650.10892011123 159844.92194690192 179475.02623335575 1.076519545952921 1.1508100698311035 1.0156072436289403 1.0140429560344233 1.0020468703303407 1.083894984286475 0.8875979821115957 0.8951112157032471 0.8906248702204923 1.0 17.45342358290904 -6.52572987860254 0.6541327211506448 0.9121272818642258 1.102785437955626 0.5314842103823623 0.057940768254643726 0.6217778988492778 0.5891710315815601 0.04322321520037907 0.05937467905471161 2.98036957588884e-07 6.52572987860254 0.19065815609140013 RSQS(ph)TTFNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R2 1 RSQSTTFNPDDMSEPEFK 18 1 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 RS(0.144)QS(0.483)T(0.134)T(0.239)FNPDDMSEPEFK 156.2 1.2393e-05 6081200.0 35083.0 38804.0 33788.0 35005.0 33936.0 23600.0 27769.0 25727.0 23329.0 27881.0 True False 33133.227308376416 41780.14202547434 31614.11686559287 30237.258613006845 29672.65628831072 26850.685780530115 29060.31352322961 25801.86131066587 27995.451866722262 27076.003086462308 1.223711904691821 1.5430690376292628 1.1676064877315504 1.116754881303922 1.095902382399517 0.9916783394796979 1.0732866823227478 0.9529420287134812 1.0339580689706624 1.0 14.724727165990924 -5.613870334693856 2.069163378859147 1.0294389438785665 1.3838361598933442 0.7018546569524299 0.08820678627347661 0.15986579940158377 1.3715166400877181 0.02465657787403307 0.0561768122839293 2.4329302894548128e-06 5.613870334693856 0.3543972160147777 RSRS(ph)ESETSTMAAK ddPTM_A459_Selumetinib_30min_R1 1 RSRSESETSTMAAK 14 2 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 RS(0.002)RS(0.936)ES(0.06)ET(0.002)S(0.001)TMAAK 90.379 0.020712 6859900.0 253.77 393.23 890.26 798.5 618.93 562.76 152.92 301.4 283.18 234.58 True False 259.6823472495374 347.1904487923326 769.3675818481381 659.0569647013929 562.9478907809668 557.0991453451976 141.38512128340167 293.40589291482314 480.53577735111617 264.6906280026969 0.9810787378799506 1.3116839512307747 2.9066672577477854 2.489914243184605 2.126814594943766 2.1047180610396277 0.5341523511817016 1.1084861414580711 1.8154620017230836 1.0 8.0481633034845 -7.238760708945403 24.59979895979707 1.1235656133491292 2.027168750807453 0.3447627584884795 0.5874897251569137 789.521328370995 856403.2605139915 0.24354694830920764 0.1885042709063401 5.77084342366861e-08 7.238760708945403 0.903603137458324 RSRS(ph)PLELEPEAK ddPTM_A459_Selumetinib_30min_R1 1 RSRSPLELEPEAK 13 2 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 RS(0.018)RS(0.982)PLELEPEAK 82.12100000000002 0.038072 16561000.0 933.96 1205.6 1771.3 2251.5 1523.2 1594.9 1309.5 914.99 645.87 731.23 True False 955.7194508301928 1064.447791531766 1530.7671890544407 1858.3177908894008 1385.4268289428019 1578.8567540533354 1210.7233607155022 890.7214928936102 1095.9942175215954 825.0904932833671 1.158320764340649 1.2900982379470884 1.8552718780735213 2.25225936550839 1.6791210663810112 1.9135558667879313 1.4673825120654909 1.0795440017119466 1.3283321362244684 1.0 9.688408547983483 -7.566228248436083 4.208949893724452 1.1586612974919306 1.7059453400284388 0.4050377765898532 0.30005823987162206 0.24173399861306027 9.325320456507455 0.1631363525857568 0.09253710853079788 2.715011988182525e-08 7.566228248436083 0.5472840425365082 RSS(ph)AIGIENIQEVQEK ddPTM_A459_Selumetinib_30min_R1 1 RSSAIGIENIQEVQEK 16 1 P47736-4;F2Z357;J3KPC5;P47736;P47736-3;A0A0A0MQY8;X6R8W7;P47736-2 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 RS(0.006)S(0.994)AIGIENIQEVQEK 125.03 0.0022249 5855500.0 2034.1 2614.5 3047.6 2985.3 3219.8 2427.0 2816.6 2630.9 1200.0 1720.6 True False 2081.4905723303955 2308.3931245519257 2633.752659268512 2463.9733960213744 2928.569658501861 2402.5865835396858 2604.1415943423303 2561.119985632408 2036.3123554676877 1941.4557700632647 1.072128762563861 1.1890011403539231 1.3565864851933702 1.2691370228542898 1.508440060113463 1.2375180627789397 1.3413344947113943 1.319175036137419 1.0488584838589097 1.0 10.922923125033773 -8.315782010034711 4.86886979222163 1.0100823434496071 1.2929146855599172 0.4838573591138402 0.10839196807542181 0.18779600534041574 9.366228988196275 0.10484423723510973 0.028230609621329148 4.83301329651703e-09 8.315782010034711 0.28283234211031005 RSS(ph)DGSLSHEEDLAK ddPTM_A459_Selumetinib_30min_R1 2 RSSDGSLSHEEDLAK 15 1 A0A2R8Y7R9;Q13136-2;Q13136;H0YEF9;E9PJZ7 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 RS(0.082)S(0.916)DGS(0.002)LSHEEDLAK;RS(0.161)S(0.839)DGSLSHEEDLAK 105.01 0.0024836 25528000.0 9888.8 9036.2 11606.0 12710.1 12575.2 9380.0 10754.7 9391.6 4380.7 7289.9 True False 10119.189799744761 7978.23750318459 10029.968947194628 10490.519633126074 11437.77538033188 9285.645716358576 9943.464320341356 9142.50425978385 7433.727946331079 8225.629674639194 1.230202452578638 0.9699242269297207 1.2193557628929579 1.2753454809021931 1.390504536764668 1.1288674646984855 1.2088392881335874 1.1114655803155729 0.9037275248666174 1.0 13.005910406514003 -8.059092570828339 3.3850177153664545 0.9542485167142297 1.2013307887523361 0.4804152313625095 0.10330316813101552 0.23321493842161126 5.101548500476574 0.08336203213269956 0.02923199244412117 8.727853124420372e-09 8.059092570828339 0.2470822720381064 RSS(ph)DGSLSHEEDLAK ddPTM_A459_Selumetinib_30min_R2 2 RSSDGSLSHEEDLAK 15 1 A0A2R8Y7R9;Q13136-2;Q13136;H0YEF9;E9PJZ7 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 RS(0.076)S(0.923)DGS(0.001)LSHEEDLAK;RS(0.044)S(0.933)DGS(0.021)LS(0.002)HEEDLAK 77.74600000000002 0.017606 31010000.0 154483.0 127241.0 170023.0 194227.0 202517.0 144257.0 134652.0 144789.0 130747.0 192557.0 True False 145897.45330444697 136999.97555570013 159083.90528704537 167772.9475397367 177075.00393504888 164127.0923153362 140913.5848078761 145210.3120188906 156900.05337641318 186997.37908683007 0.7802112201620814 0.7326304583770973 0.8507279944986641 0.897194112340116 0.9469384266226862 0.8776972870786904 0.7535591434275904 0.7765366163312047 0.8390494783542312 1.0 17.5126585242025 -12.081235496205256 1.9351796098147243 3.054131570027645 0.8293799277454984 0.3892538639176528 0.06451495859955335 3206381.789881277 177482.58195011297 28888390.380613532 0.019041724409405433 8.294009028734373e-13 12.081235496205256 -2.2247516422821465 RSS(ph)DPALIGLSTSVSDSNFSSEEPSR ddPTM_A459_Selumetinib_30min_R1 4 RSSDPALIGLSTSVSDSNFSSEEPSR 26 1 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 RS(0.238)S(0.762)DPALIGLSTSVSDSNFSSEEPSR;RS(0.336)S(0.664)DPALIGLSTSVSDSNFSSEEPSR;RS(0.236)S(0.764)DPALIGLSTSVSDSNFSSEEPSR;RS(0.457)S(0.543)DPALIGLSTSVSDSNFSSEEPSR 258.22 1.6925999999999993e-63 231458500.0 7082.29 8198.2 9175.14 9196.83 9017.77 7347.889999999999 7549.779999999999 8033.23 4796.68 6062.679999999999 True False 7247.2935772625915 7238.350932760221 7929.206383436438 7590.776286380351 8202.1142957166 7273.97689795032 6980.294016237249 7820.16264479145 8139.615624353953 6840.8840335041 1.0594089216785505 1.0581016864647137 1.1590908930194022 1.109619202606499 1.1989845545613258 1.0633094878271714 1.020378942553385 1.1431508861268818 1.1898485026919252 1.0 12.739967058361085 -10.912369748631301 3.1245873099035615 0.9986592184172453 1.1105386728912598 0.2510438118575169 0.057669494755597295 42191617.58411231 47096472.102340564 505418.7118644644 0.015044159665826867 1.2235740320602623e-11 10.912369748631301 0.1118794544740146 RSS(ph)DPALIGLSTSVSDSNFSSEEPSRK ddPTM_A459_Selumetinib_30min_R1 1 RSSDPALIGLSTSVSDSNFSSEEPSRK 27 2 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 RS(0.269)S(0.731)DPALIGLSTSVSDSNFSSEEPSRK 120.8 3.1144e-12 9243100.0 1331.6 1421.5 1943.8 1765.6 1656.0 1707.4 1528.2 1473.1 743.08 1112.3 True False 1362.623689157443 1255.0701191625785 1679.8426365291166 1457.2711044167559 1506.2150923905454 1690.225106195163 1412.9266436391217 1434.028602696834 1260.9524875841073 1255.074539719499 1.0856914438420373 0.9999964778530832 1.3384405335037317 1.1611032319581964 1.2001001093745194 1.3467129263676383 1.125771098786612 1.1425844101795979 1.0046833456329392 1.0 10.29355733400963 -8.158971689002733 2.1149188337373945 0.9926946293900935 1.1855286382522514 0.3321829200217512 0.09902430242981816 0.39775144727420414 3.167444529514014 0.0932006779261702 0.02833627131920256 6.934710108644478e-09 8.158971689002733 0.19283400886215796 RSS(ph)DSWEVWGSASTNR ddPTM_A459_Selumetinib_30min_R1 1 RSSDSWEVWGSASTNR 16 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 RS(0.003)S(0.997)DSWEVWGSASTNR 185.99 1.4199000000000004e-06 16484000.0 2487.1 2568.6 2990.8 2913.3 2838.8 2846.8 2792.4 2733.5 1595.5 1926.9 True False 2545.0445909458376 2267.8671178902564 2584.6657872884466 2404.546844413985 2582.031041230848 2818.1637766875892 2581.7670198258606 2660.99870034064 2707.4469692905786 2174.236384595435 1.1705464083747268 1.0430637321489968 1.1887694482536135 1.1059270562530874 1.1875576453069487 1.2961625500586824 1.1874362135220433 1.2238773664142217 1.245240392660598 1.0 11.086293084431329 -5.309691674430173 18.800069421509992 1.189496045714209 1.1068056213020345 0.10235997926516793 0.0816665333411251 40.701225185197984 15857.533831203624 0.020710873716358193 0.04311557447534047 4.901266592731403e-06 5.309691674430173 -0.08269042441217445 RSS(ph)DSWEVWGSASTNR ddPTM_A459_Selumetinib_30min_R2 1 RSSDSWEVWGSASTNR 16 1 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 RS(0.051)S(0.852)DS(0.092)WEVWGS(0.005)ASTNR 103.39 0.0079524 4967400.0 14590.0 16036.0 14083.0 20248.0 18481.0 10843.0 12549.0 12821.0 11017.0 16696.0 True False 13779.14620839756 17265.90963613305 13176.915112411036 17490.18747025176 16159.251557763735 12336.524827046102 13132.553365371752 12858.306987369197 13220.70784069953 16213.943098582338 0.8498331420444134 1.0648803644588274 0.812690351279397 1.0787127698617007 0.9966268821540774 0.7608590181943307 0.8099543266881203 0.7930400957490383 0.8153912814616624 1.0 13.984947364728967 -6.754439873707749 24.999861794353084 0.8212955332715264 0.9646952367746797 0.28023908933372 0.0984404453565234 183.8205760463328 656543.9776001371 0.031019519735845855 0.030378529699432714 1.760192338353117e-07 6.754439873707749 0.14339970350315334 RSS(ph)FLNAK ddPTM_A459_Selumetinib_30min_R2 1 RSSFLNAK 8 1 A0A2R8Y661;A0A2R8YGD3;Q9Y4G8;H0Y8T6 A0A2R8Y661 RAPGEF2 Rap guanine nucleotide exchange factor 2 1 RS(0.105)S(0.895)FLNAK 95.483 0.011218 9865600.0 78590.0 68477.0 66278.0 80755.0 76918.0 66749.0 76762.0 88086.0 60827.0 86133.0 True False 74222.28242069673 73728.96571174111 62013.7456380302 69756.02968985491 67254.87318435543 75943.06886290693 80331.58510101732 88342.31567657768 72994.0996483825 83646.11648958981 0.8873368607607034 0.8814391965336138 0.7413822451129352 0.8339422392495223 0.8040405939554366 0.9079090823344852 0.9603743541520544 1.056143660746908 0.8726537789410341 1.0 16.352010940120678 -7.025963439478418 2.7686410509368735 0.9769270281689106 0.8280055058939725 0.5786419113172729 0.05724514921055976 0.19625674333422718 3.0167078280553095 0.023442042365534488 0.01852697999385928 9.419688916229894e-08 7.025963439478418 -0.14892152227493816 RSS(ph)GENVENNSQR ddPTM_A459_Selumetinib_30min_R2 1 RSSGENVENNSQR 13 1 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 RS(0.008)S(0.992)GENVENNSQR 155.06 0.00066058 1019700.0 2486.7 1303.0 2239.1 3331.9 2889.5 857.44 3550.2 2371.9 2597.9 2755.7 True False 2348.499169048815 1402.9359101946468 2095.038743747751 2878.089472151907 2526.495177542252 975.5445769346501 3715.291334587842 2378.8018363108154 3117.5525913908755 2676.135780831538 0.8775710058773929 0.5242394351749677 0.782859658599525 1.075464665420533 0.944083329268596 0.3645347832954595 1.388304495309806 0.8888942980208823 1.1649455957059769 1.0 11.385935601449651 -7.2751419876162124 24.99265728638809 1.1012772495942849 0.7742229665338308 0.3668377858319588 0.2241634985822624 975.0889300972881 1778491.239803557 0.09401118775776512 0.06375455315631245 5.30710906000479e-08 7.2751419876162124 -0.32705428306045403 RSS(ph)GFISELPSEEGK ddPTM_A459_Selumetinib_30min_R1 1 RSSGFISELPSEEGK 15 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 RS(0.004)S(0.996)GFISELPSEEGK 116.61 0.0040178 56996000.0 5458.1 5653.6 7418.1 7327.2 6253.0 5792.2 5975.1 5847.0 3469.5 4368.8 True False 5585.263110386181 4991.6738837126695 6410.762764706572 6047.642068578641 5687.417254056817 5733.935726896816 5524.39339641939 5691.918566267324 5887.4880977459525 4929.578035715675 1.1330103854569196 1.0125965848490681 1.3004688673674398 1.2268072489698696 1.1537330807729307 1.163169684170415 1.1206625306251716 1.1546462040013072 1.1943188757922176 1.0 12.26724844407777 -7.191839356974937 5.648672359534807 1.1303429088549306 1.166788744497477 0.06488617116612838 0.08266555264109116 0.9286202521647844 55.8135273709871 0.033257160903278904 0.02547482769827104 6.429254877706839e-08 7.191839356974937 0.03644583564254633 RSS(ph)GFISELPSEEGK ddPTM_A459_Selumetinib_30min_R2 2 RSSGFISELPSEEGK 15 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 RS(0.286)S(0.714)GFISELPSEEGK;RS(0.355)S(0.645)GFISELPSEEGK 113.23 0.0014439 68007000.0 227436.0 203688.0 216403.0 243409.0 227396.0 157473.0 183066.0 175375.0 136983.0 201701.0 True False 214796.0176184448 219310.2146398522 202479.8665817709 210256.27429605476 198828.48153396675 179163.47635243292 191578.93173839737 175885.31221510578 164383.42762481066 195877.36804786508 1.0965841524170201 1.1196301891613176 1.0337073067690619 1.0734076958021819 1.015066127932557 0.9146716547092469 0.9780554723993569 0.8979358563370425 0.8392160322709744 1.0 17.579591190616533 -6.487755718390829 1.0041875639607087 0.9108684482869261 1.0979906022064327 0.7112809200019123 0.04632302185170438 0.27657571415981774 0.5997256728621997 0.022981318529336586 0.02787561417149812 3.2527020366138677e-07 6.487755718390829 0.1871221539195066 RSS(ph)LLNAK ddPTM_A459_Selumetinib_30min_R1 1 RSSLLNAK 8 1 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RE77 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 RS(0.011)S(0.989)LLNAK 111.27 0.02096 62103000.0 4237.7 4162.0 5036.2 5295.8 4029.1 3868.1 4434.1 4360.3 2219.5 2950.0 True False 4336.430164871202 3674.7111051386937 4352.311701866415 4370.987944477941 3664.668616395381 3829.1904259537937 4099.632267085609 4244.650679749512 3766.3293941337774 3328.6612354333542 1.3027550291721552 1.103960675247353 1.307526177652558 1.3131369146097223 1.100943699943164 1.1503695194910022 1.2316159492126517 1.2751825372211258 1.1314847404840955 1.0 11.700726336627435 -8.559332904160364 4.806594738118182 1.0000763043645815 1.2183793721802905 0.44892982834891815 0.07681573695905776 0.20082003970333054 17.17645652851305 0.07493062888969684 0.019509753054723623 2.758462573265131e-09 8.559332904160364 0.21830306781570896 RSS(ph)LLNAK ddPTM_A459_Selumetinib_30min_R2 2 RSSLLNAK 8 1 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RE77 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 RS(0.191)S(0.809)LLNAK;RS(0.226)S(0.774)LLNAK 100.82 0.0090012 57597000.0 133537.0 117678.0 129534.0 141067.0 138970.0 102708.0 115102.0 111189.0 100510.0 135059.0 True False 126115.54813096536 126703.52420559163 121199.9234659554 121853.4312458518 121511.346192437 116855.09470960537 120454.47107028624 111512.54158167026 120614.80848404362 131159.4957445753 0.9615434049591597 0.9660263138883868 0.924065183217725 0.9290477258554998 0.926439565070245 0.8909388835801348 0.9183816267856318 0.8502056290215828 0.9196040881320039 1.0 17.00096273470983 -5.422453001770249 0.9966043499966933 0.9084448735297305 0.9736194107246562 0.1600366742064232 0.03591767885649864 1.2227077438893257 1.849764440124559 0.012556192954005325 0.06872264285850099 3.780480464736722e-06 5.422453001770249 0.06517453719492572 RSS(ph)LNSISSSDAK ddPTM_A459_Selumetinib_30min_R1 1 RSSLNSISSSDAK 13 1 Q14123;A0A0A0MS69;Q14123-2;Q14123-3 Q14123 PDE1C Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C 1 RS(0.079)S(0.921)LNSISSSDAK 99.796 0.020563 6267300.0 3109.1 3804.5 3766.4 4300.5 3886.1 3655.5 3609.4 3760.3 1528.6 2543.3 True False 3181.5359807445225 3359.067371335936 3254.9435673542857 3549.498405383019 3534.602941146679 3618.7289889284416 3337.1400520553884 3660.5646288241837 2593.922555473254 2869.757328839882 1.1086428628551248 1.170505721016439 1.1342225820432412 1.2368636085400038 1.2316731124354563 1.2609878028924961 1.1628648940168222 1.2755659135485127 0.9038821956844217 1.0 11.486713030175812 -8.265621298883302 24.99253035872818 0.9519410704930902 1.1980365751918733 0.7553493599406158 0.05593782340158801 178.05492112423795 1064092.3292160323 0.048304653133346996 0.014219554774348333 5.424737167162983e-09 8.265621298883302 0.24609550469878316 RSS(ph)LNSISSSDAK ddPTM_A459_Selumetinib_30min_R2 1 RSSLNSISSSDAK 13 1 Q14123;A0A0A0MS69;Q14123-2;Q14123-3 Q14123 PDE1C Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C 1 RS(0.039)S(0.708)LNS(0.197)IS(0.053)S(0.002)S(0.001)DAK 93.716 0.030067 4081900.0 25092.0 20783.0 24976.0 24356.0 20683.0 19925.0 19749.0 20651.0 14112.0 18934.0 True False 23697.487091234514 22376.989272122297 23369.071351812687 21038.670783556492 18084.616631633973 22669.487888858595 20667.367631901096 20711.090991042918 16934.794322224905 18387.326223560027 1.2887946188103454 1.2169789669283313 1.2709336348136064 1.1441941328369563 0.9835370521931467 1.2328865879266206 1.124000704649467 1.1263786120521104 0.9210036367618275 1.0 14.166424086354212 -1.5228787452803376 0.15567311493473585 0.9518895524691102 2.249303486080071 0.5475079934208127 0.08114116786832426 54.02768723011325 0.5483055981775068 0.26917256352796615 15.96066574433576 0.029999999999999995 1.5228787452803376 1.297413933610961 RSS(ph)LPLDHGSPAQENPESEK ddPTM_A459_Selumetinib_30min_R1 1 RSSLPLDHGSPAQENPESEK 20 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 RS(0.027)S(0.973)LPLDHGSPAQENPESEK 175.74 2.4620999999999997e-13 5387400.0 1947.8 1778.2 1962.3 2329.4 3688.0 2134.9 2716.6 1756.1 983.74 1078.2 True False 1993.1799502409624 1570.0075173372486 1695.8304381423432 1922.6140182535062 3354.421051169286 2113.424844334106 2511.684674852793 1709.5225233832816 1669.3349304731519 1216.5974725573706 1.6383232705975976 1.2904905301479759 1.393912511241366 1.5803205757217635 2.7572152062079045 1.7371603114475846 2.0645157757668695 1.4051669199918269 1.3721341430737124 1.0 10.248636196834605 -6.007152676234941 24.94577354274105 1.7978615979599855 1.4360750980310173 0.05883028259000245 0.45067298801605576 747.3001857071275 2606314.195752142 0.13116104889422098 0.18608417731558294 9.836652374332061e-07 6.007152676234941 -0.36178649992896816 RSS(ph)LPLDHGSPAQENPESEK ddPTM_A459_Selumetinib_30min_R2 1 RSSLPLDHGSPAQENPESEK 20 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 RS(0.261)S(0.738)LPLDHGSPAQENPESEK 114.64 0.00014077 6646100.0 19651.0 23198.0 35200.0 61117.0 64840.0 31461.0 25228.0 36051.0 37313.0 43599.0 True False 18558.876089185786 24977.21200667338 32935.27032286221 52792.75916729435 56694.21952304536 35794.467175477024 26401.151988333648 36155.90244143565 44776.642612328345 42340.18358619381 0.4383277189009974 0.5899174233816477 0.7778726385494859 1.2468712862291154 1.33901685635421 0.845401794316943 0.6235483588442086 0.8539382539008472 1.05754483849071 1.0 15.369739904405513 -5.350767185262973 2.8948945429383763 0.9820825069368442 0.49374835199740535 0.48648017501974816 0.19604471363377615 0.26010372295054823 4.168177084366492 0.061160730957323974 0.160636168108054 4.4589521794911125e-06 5.350767185262973 -0.4883341549394388 RSS(ph)LPNGEGLQLK ddPTM_A459_Selumetinib_30min_R1 1 RSSLPNGEGLQLK 13 1 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 RS(0.11)S(0.89)LPNGEGLQLK 150.12 0.00089962 22154000.0 2713.8 2833.1 2832.0 3190.0 2672.9 2704.3 2723.6 2765.0 1795.5 1981.6 True False 2777.0262598644244 2501.399334927541 2447.4299550624833 2632.9263837162703 2431.136666938823 2677.0971973079404 2518.156659217061 2691.66321801422 3046.8323618685286 2235.9576624185534 1.2419851710701073 1.1187149814911383 1.0945779502887314 1.1775385679120285 1.0872910108276164 1.1972933308639764 1.1262094544729722 1.2038077747423654 1.3626520810652925 1.0 11.126677155849869 -7.834115719246625 6.804934121933663 1.2137725619674407 1.146473685051234 0.01621040699703591 0.093787171747827 0.5407045121195357 40.742813191604746 0.048370200378127295 0.023106205437842576 1.4651573927533106e-08 7.834115719246625 -0.06729887691620662 RSS(ph)LPNGEGLQLK ddPTM_A459_Selumetinib_30min_R2 3 RSSLPNGEGLQLK 13 1 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 RS(0.045)S(0.955)LPNGEGLQLK;RS(0.001)S(0.999)LPNGEGLQLK;RS(0.046)S(0.954)LPNGEGLQLK 144.17 0.0003508 38543000.0 233759.0 213780.0 239995.0 268603.0 271682.0 166558.0 176522.0 185121.0 152439.0 220134.0 True False 220767.61059141916 230176.23858895706 224553.98298679898 232018.80803398023 237550.878292104 189499.8526370142 184730.62277170722 185659.6714615687 182931.05950153363 213778.1594431791 1.032694879432236 1.0767060544841882 1.0504065689951083 1.0853251269367832 1.1112027482641114 0.886432239526237 0.8641229920440375 0.8684688461400843 0.8557050915678577 1.0 17.70575494268452 -6.769335527513923 24.999023235593032 0.8847986661085788 1.0711913296595557 0.8062011770190958 0.04308094791064091 68.35417520659954 216406.48556954006 0.014362552215957492 0.01289449081447368 1.7008439615271087e-07 6.769335527513923 0.18639266355097683 RSS(ph)LPSFETLDYGDEEDIETQLSSSGK ddPTM_A459_Selumetinib_30min_R1 2 RSSLPSFETLDYGDEEDIETQLSSSGK 27 1 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8;K7EPU8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 RS(0.148)S(0.701)LPS(0.148)FET(0.003)LDYGDEEDIETQLSSSGK;RS(0.15)S(0.81)LPS(0.02)FET(0.02)LDYGDEEDIETQLSSSGK 149.07 4.0038999999999996e-14 37423000.0 2252.0 3324.5 3328.7 4036.8 3280.4 2525.7 3058.3 2475.3 1508.69 2060.7799999999997 True False 2304.467218370803 2935.265994481879 2876.6808232402877 3331.8486601209547 2983.6883992016583 2500.2937511521163 2827.6099687485453 2409.6470030924406 2560.136739642121 2325.301186697068 0.9910403140696548 1.262316473786015 1.237121814454676 1.4328675696646502 1.2831406169107 1.0752558702744281 1.2160188043274398 1.0362730715822583 1.100991456198679 1.0 11.183201879339615 -7.53992336852549 1.1092113616837949 1.035227360147685 1.2420480157233458 0.30342478677981033 0.11479205892834164 0.6533213796160839 1.489892456333749 0.09460444237667166 0.0431759431612226 2.8845404368004685e-08 7.53992336852549 0.20682065557566087 RSS(ph)LPSFETLDYGDEEDIETQLSSSGK ddPTM_A459_Selumetinib_30min_R2 1 RSSLPSFETLDYGDEEDIETQLSSSGK 27 1 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8;K7EPU8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 RS(0.152)S(0.457)LPS(0.068)FET(0.311)LDY(0.012)GDEEDIETQLSSSGK 83.435 3.9251e-05 6251500.0 34401.0 29847.0 38158.0 45678.0 36983.0 30742.0 29941.0 33909.0 26187.0 30994.0 True False 32489.13013811411 32136.1689267687 35702.955823289114 39456.57760105492 32336.864907785086 34976.43145190917 31333.31582696596 34007.669576062865 31425.131725914354 30099.12268791693 1.079404555241626 1.0676779273593089 1.1861792848075867 1.310887962089821 1.0743457622692265 1.162041558970428 1.041004289455403 1.129855840938347 1.0440547404569285 1.0 14.877433816293987 -8.110476137064472 0.7438201089018683 1.0044180544889052 1.1496951259767394 0.29299334934211974 0.07255960174462629 0.8781074559811277 1.024196941714775 0.07321195819084018 0.030776795896788847 7.753965474686933e-09 8.110476137064472 0.1452770714878342 RSS(ph)LYGIAK ddPTM_A459_Selumetinib_30min_R2 2 RSSLYGIAK 9 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 RS(0.139)S(0.861)LYGIAK;RS(0.028)S(0.972)LYGIAK 106.54 0.0067288 32597000.0 259540.0 223720.0 239320.0 302830.0 268560.0 204972.0 242350.0 233420.0 205701.0 242543.0 True False 245115.80582093901 240878.6046268195 223922.41175191416 261584.03158911254 234821.0918431376 233205.03244944147 253619.7552074149 234099.21355523868 246846.94776615582 235540.15338760495 1.0406540128959514 1.0226647183609054 0.9506761736009715 1.110570863722967 0.9969471806223882 0.9900861024985375 1.0767580455382406 0.9938824025897823 1.0480036809687578 1.0 17.845613496717334 RSS(ph)PAAFINPPIGTVTPALK ddPTM_A459_Selumetinib_30min_R2 2 RSSPAAFINPPIGTVTPALK 20 1 F6VRR5;Q9BY77-2;Q9BY77;Q6R954;F8WEE2;Q8WUT1;F8WCX5 F6VRR5 POLDIP3;PDIP46 Polymerase delta-interacting protein 3 1 RS(0.227)S(0.773)PAAFINPPIGTVTPALK;RS(0.237)S(0.763)PAAFINPPIGTVTPALK 123.85 0.0001214 25247000.0 128518.0 140490.0 143654.0 149462.0 161001.0 117539.0 102615.0 110399.0 95478.0 148423.0 True False 121375.4840583166 151265.13125345015 134411.4580386492 129105.01776366869 140774.61501279785 133728.93033719203 107386.80082776498 110720.24281246163 114576.2678782165 144137.6423407335 0.8420804037531819 1.0494491847998155 0.9325215527038238 0.8957064627050823 0.9766679454907023 0.9277863031855631 0.7450295362394541 0.7681563331716293 0.7949087137651696 1.0 17.137087626927098 -7.160759104412573 6.543918962343622 0.8081370613991053 0.9432373438423494 0.29071711476450723 0.082259272063649 0.2517503513602189 13.938987492790435 0.02999958937991896 0.02317581223720395 6.906227740450078e-08 7.160759104412573 0.135100282443244 RSS(ph)PPGHYYQK ddPTM_A459_Selumetinib_30min_R1 1 RSSPPGHYYQK 11 1 D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;D6RDK6;D6RBN5;Q9NX40-3;Q9NX40-2;Q9NX40-4;Q9NX40 D6RI08 OCIAD1 OCIA domain-containing protein 1 1 RS(0.078)S(0.922)PPGHYYQK 86.189 0.01736 15069000.0 3429.9 3919.4 4438.0 4687.4 4980.0 3879.0 3925.0 3781.4 1684.7 2755.6 True False 3509.8099965763836 3460.514825920373 3835.3439761890204 3868.8335833955025 4529.559879290411 3839.980781850205 3628.9340899643703 3681.1049882817256 2858.8128543803437 3109.3081018170005 1.128807400760748 1.112953336434603 1.233503998509425 1.2442747571830062 1.4567742182395664 1.2349952645754911 1.167119491260359 1.1838984326225443 0.9194369810794003 1.0 11.602377865297356 -8.164691453345885 3.8162629417673815 0.9592148285430847 1.2286622991230063 0.5660709914680104 0.09147011191883078 0.18572175188946963 4.712818847375731 0.07947020168969808 0.026372436038489665 6.843977083221519e-09 8.164691453345885 0.2694474705799216 RSS(ph)PPGHYYQK ddPTM_A459_Selumetinib_30min_R2 1 RSSPPGHYYQK 11 1 D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;D6RDK6;D6RBN5;Q9NX40-3;Q9NX40-2;Q9NX40-4;Q9NX40 D6RI08 OCIAD1 OCIA domain-containing protein 1 1 RS(0.001)S(0.999)PPGHYYQK 100.88 0.008125799999999999 4557200.0 28936.0 25329.0 36651.0 44040.0 41721.0 28367.0 30783.0 28098.0 28861.0 33871.0 True False 27327.85295998574 27271.652854428416 34292.914562591555 38041.6760267625 36479.6349895277 32274.296760012614 32214.4704953573 28179.76052812568 34634.0064437169 32893.05622257324 0.8308091767171115 0.8291006062158774 1.042557867853509 1.156526039093198 1.109037565335541 0.9811887512557742 0.9793699398856632 0.8567084900060759 1.0529275908375126 1.0 15.005495440392453 -5.257797841613736 24.464925798294473 1.0220635566881806 0.8299548590778433 0.503601116449405 0.07638147572530266 206.2262532068002 1385466.8938454338 0.022243118006143526 0.05421831087057378 5.523344839099603e-06 5.257797841613736 -0.19210869761033733 RSS(ph)PPPPPSGSSSR ddPTM_A459_Selumetinib_30min_R1 3 RSSPPPPPSGSSSR 14 1 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 RS(0.394)S(0.606)PPPPPSGSSSR;RS(0.405)S(0.595)PPPPPSGSSSR;RS(0.061)S(0.939)PPPPPSGSSSR 123.76 0.0024728000000000003 44271400.0 2874.5 2994.8199999999997 3391.29 3371.87 3033.14 2801.86 2920.1800000000003 2788.13 1590.58 2437.4000000000005 True False 2941.470257196658 2644.1850821459525 2930.771445022548 2783.036202338992 2758.793022544361 2773.675832285336 2699.9084715495937 2714.179735277393 2699.0980886331618 2750.2640322865277 1.0695228613200327 0.9614295395295619 1.0656327576614342 1.011916008669618 1.0031011532557266 1.008512564511613 0.9816906449178012 0.9868796971543365 0.9813959885113913 1.0 11.425354412312211 -6.656019850373118 1.2147421578928608 0.9867276465128559 1.0256929222984932 0.2647240864035705 0.028716295351619722 0.6476176313389786 2.0173027984761736 0.013044200052981172 0.012995578225405141 2.2079038136704562e-07 6.656019850373118 0.03896527578563724 RSS(ph)PPPPPSGSSSR ddPTM_A459_Selumetinib_30min_R2 2 RSSPPPPPSGSSSR 14 1 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 RS(0.23)S(0.77)PPPPPSGSSSR;RS(0.199)S(0.798)PPPPPS(0.001)GSS(0.002)SR 116.87 0.0019228 10036700.0 26852.0 22081.0 29993.7 32082.4 27938.9 20653.3 20601.1 25127.9 21806.6 26310.7 True False 25359.673337072745 23774.541698394474 28063.93799667139 27712.72177477306 24428.965605064943 23498.104603009426 21559.091970305224 25201.018028852228 26168.52932731218 25551.041727591666 0.9925103487928529 0.930472500959567 1.0983480946049309 1.0846024232682097 0.9560849168308064 0.9196534862856356 0.8437656750027661 0.9863010008565929 1.024166826789442 1.0 14.641094491244369 -6.422928155676243 8.496273266005256 0.9459905351389604 1.0246170551232838 0.22558722745630533 0.06381863167516405 0.5053547917082141 39.09071150420142 0.021498110939961502 0.024361377098353204 3.7763465697946615e-07 6.422928155676243 0.07862651998432346 RSS(ph)PSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R1 1 RSSPSARPPDVPGQQPQAAK 20 2 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 RS(0.238)S(0.752)PS(0.009)ARPPDVPGQQPQAAK 119.18 0.00028893 33543000.0 3096.4 3119.7 3728.0 3746.5 3698.8 3255.4 3054.6 2989.1 1753.8 2650.7 True False 3168.5400954544216 2754.444073690816 3221.7580764381846 3092.2441055150525 3364.2441930761775 3222.6536316667066 2824.189062727431 2909.8193580348316 2976.070507516023 2990.9431650044735 1.05937823644659 0.9209282563169989 1.077171279659995 1.0338692295112293 1.1248104719740288 1.0774707020091057 0.9442469839520361 0.972876847705155 0.9950274356054412 1.0 11.546384780761196 -7.260842449555033 24.99999241142227 0.9757775537555688 1.047166535071143 0.31566808646504785 0.05105794113410072 72.25902815232912 3026372.016896369 0.021600408642806938 0.015714505004516658 5.48475901250221e-08 7.260842449555033 0.07138898131557414 RSS(ph)PSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R2 2 RSSPSARPPDVPGQQPQAAK 20 2 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 RS(0.235)S(0.6)PS(0.165)ARPPDVPGQQPQAAK;RS(0.196)S(0.789)PS(0.014)ARPPDVPGQQPQAAK 86.073 0.0026268 50090300.0 17374.6 12563.7 16387.5 18048.6 16450.9 13173.7 12344.0 14920.400000000001 14724.7 16786.2 True False 16408.98928803456 13527.295391337293 15333.14609136092 15590.349544428369 14384.19086908802 14988.257596058025 12918.020459171961 14963.815893794817 17670.051442493266 16301.538790214603 1.0065914328213272 0.8298170844740977 0.940595013064964 0.956372876515612 0.8823823967908159 0.91943820696578 0.7924417826693955 0.9179388575744281 1.0839499061953677 1.0 13.99272053420391 -8.192347862359231 6.496566707450814 1.0412056392314466 0.9013450308789416 0.44497424930700613 0.06083090149214214 0.18633290184850673 14.183420576937113 0.041101858249616326 0.015096891091183545 6.4217314169560635e-09 8.192347862359231 -0.13986060835250502 RSS(ph)PSSSSTQPQEESR ddPTM_A459_Selumetinib_30min_R1 1 RSSPSSSSTQPQEESR 16 1 Q4G0A6 Q4G0A6 FAM188B Protein FAM188B 1 RS(0.089)S(0.783)PS(0.12)S(0.006)S(0.001)STQPQEESR 166.79 2.8432e-05 1226900.0 288.08 367.62 336.73 368.3 442.72 234.16 386.59 411.64 257.45 267.12 True False 294.7917034938992 324.5788794980987 291.00391552549115 303.98331884724246 402.67605416856435 231.80456300026907 357.4292050546055 400.7219700048366 436.87384659596324 301.4074539691382 0.9780504749032637 1.0768774136930703 0.9654834732630325 1.0085461220158412 1.3359857192177977 0.7690737569615782 1.185867171988399 1.3295025213472902 1.4494460599527699 1.0 8.23557128577926 -7.514632316036698 23.375768771391208 1.2852216895897433 1.0309951825364723 0.2928804467025027 0.1678117916936945 192.55727563757193 545844.334744998 0.07226016404149585 0.04435076565986969 3.057508576714598e-08 7.514632316036698 -0.254226507053271 RSS(ph)PSSSSTQPQEESR ddPTM_A459_Selumetinib_30min_R2 1 RSSPSSSSTQPQEESR 16 1 Q4G0A6 Q4G0A6 FAM188B Protein FAM188B 1 RS(0.177)S(0.613)PS(0.111)S(0.071)S(0.021)S(0.006)TQPQEESR 94.958 0.0045961000000000005 5722500.0 0.0 662.14 2131.0 1111.5 965.48 1229.8 2524.3 1166.8 775.76 1074.5 True False 0.0 712.9240088843311 1993.8937800573688 960.1117825555524 844.1877708992881 1399.193786987116 2641.6849518055565 1170.1951948258616 930.9336765454354 1043.4763931137243 0.0 0.6832200647654062 1.910818292791088 0.9201087718818318 0.809014728527053 1.3408964459770232 2.5316192769084043 1.1214390690085565 0.8921463702379866 1.0 10.027182246996917 -6.85258122732387 5.75359801598062 1.4671467015468314 0.9172432175513454 0.14217207706936486 0.6084027586830563 0.4337663656473986 21.9515616460854 0.22811589211429376 0.20176097193265058 1.4041670336894337e-07 6.85258122732387 -0.5499034839954859 RSS(ph)PTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R2 1 RSSPTQETQAPFIAK 15 1 O15231-5 O15231-5 ZNF185 Zinc finger protein 185 1 RSS(0.955)PT(0.038)QET(0.007)QAPFIAK 111.81 0.0056804 3723200.0 8766.0 9842.1 11797.0 9188.5 8950.4 5275.7 5669.0 5552.6 4181.3 9815.7 True False 8278.82081307834 10596.957422660575 11037.993863602434 7937.010448953386 7825.970734408781 6002.3797869636755 5932.619732910391 5568.7571467175885 5017.676835283374 9532.295236748609 0.8685023499022657 1.1116900137343118 1.157957615606481 0.8326442112656005 0.8209954203095118 0.6296888249771668 0.6223705398925475 0.5841989791974853 0.5263870569114752 1.0 13.218607920411518 -6.247513686074995 1.661362765561336 0.6462501447493126 1.0463616650323726 0.522328520134772 0.14679002024058463 0.26066360588975873 1.425096481039204 0.050981205320773014 0.06924589591975908 5.655699338037656e-07 6.247513686074995 0.40011152028305996 RSS(ph)PVPPVPER ddPTM_A459_Selumetinib_30min_R2 1 RSSPVPPVPER 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RS(0.114)S(0.886)PVPPVPER 105.66 0.020773 31781000.0 90622.0 77185.0 87251.0 89050.0 114230.0 70202.0 64537.0 70438.0 63956.0 80661.0 True False 85585.59202860887 83104.84131110825 81637.36565170587 76921.23638018158 99879.40617084311 79871.6882696939 67538.09837763938 70642.96291836142 76748.98707994726 78332.10734755328 1.0925991260374557 1.0609294722836797 1.042195447257501 0.9819885993732841 1.2750762050570936 1.0196545321487347 0.8622019841490828 0.901839173111024 0.9797896377205602 1.0 16.257316150878957 -7.005061515466259 24.993302318147535 0.9296562749558792 1.0869105352343102 0.4607382442336865 0.07868113683301792 200.47473791059642 989930.1305045623 0.02847500126656924 0.02442156956562379 9.884130813699163e-08 7.005061515466259 0.15725426027843104 RSS(ph)PVPPVPERR ddPTM_A459_Selumetinib_30min_R1 1 RSSPVPPVPERR 12 2 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 RS(0.338)S(0.662)PVPPVPERR 92.269 0.024754 19443000.0 1400.9 1389.8 1883.7 2084.8 2203.1 1327.2 1278.7 1554.4 1062.2 1436.1 True False 1433.538244323117 1227.0815698995088 1627.903886423447 1720.728816542848 2003.8299939888973 1313.8495730011828 1182.2466295127238 1513.1722625972172 1802.47581998148 1620.4374237985887 0.8846612792752296 0.7572532896845934 1.0046076834040005 1.0618915554968849 1.2365981953758938 0.8107993272096182 0.7295848714363378 0.9338048112034322 1.1123390471667591 1.0 10.662167594044428 -5.270311667390662 24.59563029643538 0.9800555486572303 0.820957282563348 0.18381675142161857 0.13879824950411285 882.6148724790712 2446778.37956918 0.040057370593698016 0.0855029840001771 5.3664653875738615e-06 5.270311667390662 -0.15909826609388233 RSS(ph)SSGDQSSDSLNS(ph)PTLLAL ddPTM_A459_Selumetinib_30min_R1 1 RSSSSGDQSSDSLNSPTLLAL 21 1 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 2 RS(0.203)S(0.311)S(0.125)S(0.15)GDQS(0.095)S(0.114)DS(0.001)LNS(0.542)PT(0.458)LLAL 68.40100000000001 0.026102 4602000.0 593.36 660.23 614.67 764.07 889.81 755.18 789.06 693.57 447.86 690.82 True False 607.1841335224242 582.9299646674002 531.2011901406274 630.6395178702479 809.3268426087145 747.5835748485781 729.5405689241489 675.174270567133 759.9857095997983 779.4934761566337 0.7789470368837504 0.7478317426613902 0.6814697061478502 0.8090375829438312 1.0382727596376777 0.9590632862440486 0.9359161958881524 0.866170521267405 0.9749737911175084 1.0 9.606393138347743 -6.063681924079688 5.177403918651292 0.9533426901658326 0.7377756947901661 0.8236158463852311 0.047915106282905226 0.08916061322464591 4.764937707948315 0.014797949051994108 0.019673819871728854 8.636108220660296e-07 6.063681924079688 -0.21556699537566648 RSS(ph)SSGDQSSDSLNSPTLLAL ddPTM_A459_Selumetinib_30min_R1 2 RSSSSGDQSSDSLNSPTLLAL 21 1 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 1 RS(0.151)S(0.661)S(0.151)S(0.035)GDQS(0.001)S(0.001)DSLNSPTLLAL;RS(0.194)S(0.318)S(0.318)S(0.167)GDQS(0.002)S(0.002)DSLNSPTLLAL 136.43 5.9795e-05 37312000.0 3497.5099999999998 4044.58 4596.4 4843.2 4191.75 4003.88 4698.2699999999995 4159.7 2741.43 2852.41 True False 3578.9951780302226 3571.0386933257696 3972.234126217937 3997.426038123712 3812.6069526135716 3963.6046024321704 4343.875711301124 4049.371243390147 4652.006483874819 3218.5446083262555 1.111991789323502 1.1095197139998076 1.2341709094048021 1.2419980222683629 1.1845748363252444 1.2314897212169973 1.3496397409138525 1.2581373683355432 1.4453757986887152 1.0 11.65219274908687 -5.051427427403446 0.7195134843136046 1.270808799310561 1.0255820538937066 0.1658825634499942 0.10932511595134978 3.334990840795966 1.6828475836306644 0.04610241047605979 0.6248249387227863 8.883264073274491e-06 5.051427427403446 -0.2452267454168544 RSS(ph)SSGDQSSDSLNSPTLLAL ddPTM_A459_Selumetinib_30min_R2 2 RSSSSGDQSSDSLNSPTLLAL 21 1 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 1 RS(0.186)S(0.563)S(0.186)S(0.062)GDQS(0.001)S(0.001)DS(0.002)LNSPTLLAL;RS(0.055)S(0.729)S(0.2)S(0.015)GDQSSDSLNSPTLLAL 188.09 2.5186e-16 27252000.0 26054.6 28586.0 32990.0 28296.0 24724.6 23052.0 23902.1 26791.0 26944.0 36968.0 True False 24606.589636827648 30778.454281522787 30867.459316796154 24442.035986677376 21618.47470727155 26227.203754778817 25013.595011112626 26868.957374511207 32333.552878261573 35900.63778560089 0.685408147447924 0.8573233284971745 0.8598025333459827 0.6808245617430407 0.6021752269800159 0.7305498000177056 0.6967451430945089 0.748425627839065 0.9006400686070816 1.0 15.131721853735668 -8.407001843416909 2.55944836055083 0.997629262459529 0.73223893067015 0.5943397435438406 0.0742585751587184 0.20374020334342602 2.6649447085270195 0.07876866380595325 0.021589824717935312 3.917402143142232e-09 8.407001843416909 -0.265390331789379 RSS(ph)TSGDTEEEEEEEVVPFSSDEQK ddPTM_A459_Selumetinib_30min_R1 1 RSSTSGDTEEEEEEEVVPFSSDEQK 25 1 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.128)S(0.522)T(0.128)S(0.128)GDT(0.092)EEEEEEEVVPFSSDEQK 115.54 4.0052e-08 8044700.0 1048.7 846.6 843.92 1134.1 989.67 805.29 835.28 965.21 499.5 616.88 True False 1073.1326695850184 747.4796784263382 729.320299320739 936.0507246936129 900.1545232404301 797.189513744818 772.274157112214 939.6094953560595 847.6150179634243 696.0625569200436 1.541718713233829 1.0738685352273603 1.047779818164412 1.3447795968734124 1.2932092299626892 1.1452842935155767 1.1094895845703776 1.3498923135783498 1.217728219305423 1.0 9.443073160364065 -10.761481612117644 3.0660088090148605 0.9989495587246274 1.2275163043830193 0.1917949170903207 0.14438363460813972 24299346.641959794 33268707.022297062 242112.17862899246 0.0354563279061333 1.7318823565145353e-11 10.761481612117644 0.22856674565839186 RSS(ph)TSGDTEEEEEEEVVPFSSDEQKR ddPTM_A459_Selumetinib_30min_R1 1 RSSTSGDTEEEEEEEVVPFSSDEQKR 26 2 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.225)S(0.622)T(0.052)S(0.019)GDT(0.082)EEEEEEEVVPFSSDEQKR 128.47 7.4354e-09 4211900.0 436.17 391.5 692.58 648.31 522.23 394.75 628.1 419.7 407.63 413.85 True False 446.33191236092057 345.6629979965879 598.531440069624 535.0948287859233 474.994388707195 390.7791734043228 580.7219113137892 408.5681926222668 691.7183378827443 466.97167874037046 0.9558008176531723 0.7402226167740925 1.281729636546971 1.145882830045092 1.0171802923647648 0.8368369886123017 1.2435912877634325 0.8749314170922662 1.481285417027035 1.0 8.867191244677935 -8.245030251255923 24.80472627230585 1.2406428090942812 1.01846571715456 0.17712043377068654 0.19671839847256908 1116.3813953882939 1687575.9327665393 0.13017204728381915 0.04888278521987339 5.688133081523607e-09 8.245030251255923 -0.22217709193972124 RSS(ph)TSGDTEEEEEEEVVPFSSDEQKR ddPTM_A459_Selumetinib_30min_R2 1 RSSTSGDTEEEEEEEVVPFSSDEQKR 26 2 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.211)S(0.36)T(0.36)S(0.067)GDT(0.003)EEEEEEEVVPFSSDEQKR 112.14 5.9926e-09 4901200.0 8884.8 9229.1 11043.0 11959.0 12305.0 8053.4 8840.5 7850.3 6719.2 11068.0 True False 8391.018384672425 9936.942293766251 10332.505402709305 10330.163569574315 10759.135891904272 9162.682748513605 9251.600767118418 7873.143073312871 8063.227750134173 10748.438081882456 0.780673277433333 0.9245010501121963 0.9613029655095426 0.9610850889104359 1.0009952897286396 0.8524664401200955 0.8607390856828674 0.7324918293555437 0.7501766943911164 1.0 13.391839408179088 -7.097276926396744 2.699887236618978 0.8117389612706499 0.9289467677049402 0.16515417046215375 0.08846998861317042 0.3960491926114106 5.624771177783061 0.03737007540767239 0.028163333016049168 7.993244059883788e-08 7.097276926396744 0.1172078064342903 RSS(ph)TSSEPTPTVK ddPTM_A459_Selumetinib_30min_R1 3 RSSTSSEPTPTVK 13 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 RS(0.006)S(0.99)T(0.004)SSEPTPTVK;RS(0.001)S(0.908)T(0.084)S(0.007)SEPTPTVK;RSS(0.997)T(0.003)SSEPTPTVK 228.11 1.0553e-12 34580300.0 13570.9 15493.6 17693.0 17461.2 16985.5 15390.7 19482.5 20088.600000000002 12456.4 10631.3 True False 13887.07556562537 13679.602109220777 15290.38778069228 14411.929207318673 15449.164524033582 15235.883531637515 18012.919339549273 19555.785071030918 21137.601020539747 11995.930912631395 1.157648844993151 1.1403535256122992 1.2746311971997029 1.2014014845770158 1.2878670806419887 1.2700876357661028 1.5015857852750845 1.6302015419611326 1.762064251160568 1.0 13.550257498074885 -7.2029082484386855 2.7723106471597094 1.532000132232416 1.2139799911141103 0.2805093174327459 0.1906590958518823 0.29860162021900244 4.523105827179063 0.08032924208538882 0.05673336257476229 6.267462607224332e-08 7.2029082484386855 -0.3180201411183057 RSS(ph)TSSEPTPTVK ddPTM_A459_Selumetinib_30min_R2 3 RSSTSSEPTPTVK 13 1 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 RS(0.002)S(0.974)T(0.023)SSEPTPTVK;RS(0.009)S(0.981)T(0.009)SSEPTPTVK;RS(0.154)S(0.526)T(0.154)S(0.154)S(0.013)EPTPTVK 224.06 7.6012e-09 33835300.0 122655.0 122492.0 123087.0 139147.0 123165.0 79770.0 92954.0 125292.0 109276.0 184597.0 True False 115838.32612686785 131886.7425261417 115167.71642699277 120194.93855803617 107691.91159092964 90757.59342003768 97276.54518485666 125656.57897679285 131134.253426548 179267.2049693941 0.6461768963634184 0.7356992180954594 0.6424360576529048 0.6704792356112027 0.6007340361518753 0.5062699194508695 0.5426343608216821 0.7009457139594826 0.7315016343839146 1.0 17.45175206105089 -8.705596815427047 1.5690183639877133 0.9985994123503533 0.6252448762989729 0.7571845170428144 0.06358750942252674 0.3712293783530889 1.763065918105663 0.0690396811776644 0.019951575973252825 1.969714058268143e-09 8.705596815427047 -0.37335453605138047 RSS(ph)TVAPAQPDGAESEWTDVETR ddPTM_A459_Selumetinib_30min_R1 1 RSSTVAPAQPDGAESEWTDVETR 23 1 Q02241;H7BYN4;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 RS(0.084)S(0.458)T(0.458)VAPAQPDGAESEWTDVETR 182.98 2.2676999999999997e-17 10642000.0 394.66 513.72 550.77 403.99 344.54 447.72 438.35 461.72 246.03 281.63 True False 403.8548101253202 453.57342357805146 475.97845916305255 333.44073033151625 313.3764178334775 443.21634329723446 405.2849065823903 449.4736857220707 417.4949406797625 317.7799538085071 1.2708630776901726 1.4273191815345687 1.4978240554779463 1.0492818264189385 0.986142813848846 1.3947271940391646 1.2753633504101185 1.4144179969039887 1.3137862715259354 1.0 8.311884309259083 -11.781873078410264 2.0628260451272356 0.0001698673809754454 1.2921839496532328 0.24261371730655412 0.1548781681066316 3434769.0555553823 510795.22632172535 16012574.025342464 0.04394859739610754 1.6524446509178591e-12 11.781873078410264 1.2920140822722574 RSSIT(ph)EPEGPNGPNIQK ddPTM_A459_Selumetinib_30min_R1 1 RSSITEPEGPNGPNIQK 17 1 Q13625-2;Q13625;Q13625-3 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 RS(0.125)S(0.39)IT(0.485)EPEGPNGPNIQK 159.47 3.8597e-05 21866000.0 1413.1 1238.7 1838.5 1600.1 1716.3 1344.3 1511.0 1738.7 738.57 1006.2 True False 1446.0224805860491 1093.672428143993 1588.8417981576185 1320.6725725969923 1561.0609680373755 1330.7775625267407 1397.0240534869201 1692.584027906446 1253.2993469814749 1135.3555712179807 1.2736296163454703 0.9632862654390545 1.3994222060787083 1.1632237565718802 1.374953369333194 1.172124043130485 1.230472716127361 1.4907964260841076 1.1038826767168342 1.0 10.14892847688901 -5.264973482554602 24.99122452803078 1.2584355626162473 1.1184579502711858 0.08341401479736021 0.1560686220212701 576.8160096166246 4078952.8908390296 0.03744778192422341 0.08319838256961769 5.43283502650267e-06 5.264973482554602 -0.13997761234506156 RSSPS(ph)ARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R1 1 RSSPSARPPDVPGQQPQAAK 20 2 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 RS(0.088)S(0.088)PS(0.823)ARPPDVPGQQPQAAK 86.74799999999998 0.002516 15793000.0 1666.7 1997.6 1798.0 2090.5 1511.1 1771.5 1858.7 1531.5 807.61 1646.1 True False 1705.5308671663488 1763.7200633409557 1553.8414757070439 1725.4334185450987 1374.4212718063736 1753.680318393306 1718.4967625520458 1490.8796449868998 1370.4551844993828 1857.392969371811 0.918239110026984 0.9495675349398267 0.836571205625145 0.9289544253678625 0.7399733359985834 0.9441622463911976 0.9252198058729912 0.8026732466264963 0.7378380380985745 1.0 10.859063363794535 -5.257605831295759 24.76341767771902 0.8602557131371648 0.9339033263600752 0.09861293299540608 0.08326463187123154 632.8234005022415 4087776.5734397937 0.021063294427619377 0.051331987348585836 5.525787360753582e-06 5.257605831295759 0.07364761322291047 RSSSSGDQSS(ph)DSLNS(ph)PTLLAL ddPTM_A459_Selumetinib_30min_R1 1 RSSSSGDQSSDSLNSPTLLAL 21 1 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 2 RS(0.058)S(0.178)S(0.085)S(0.041)GDQS(0.211)S(0.254)DS(0.174)LNS(0.952)PT(0.048)LLAL 65.085 0.034805 5330800.0 993.88 869.22 937.71 977.75 895.15 861.66 1472.8 1283.9 885.23 817.43 True False 1017.0354702461689 767.4513183105852 810.3741324723312 807.0043171406226 814.183840551569 852.992482724683 1361.7055102419172 1249.8468013050474 1502.1706553588842 922.3551029424697 1.1026506678411088 0.8320562393619171 0.8785923446263808 0.8749388544240082 0.8827227582459121 0.9247983558647769 1.4763354221143732 1.3550603203883445 1.628625082212593 1.0 9.849178479066794 -7.253928873139925 23.930993662483672 1.3945935725932552 0.9070721323870639 0.6439769263681646 0.16289523085294194 175.7636928547859 560043.3446009277 0.0589277885875787 0.0446792249183467 5.5727700986181665e-08 7.253928873139925 -0.48752144020619137 RSSSSGDQSSDSLNS(ph)PTLLAL ddPTM_A459_Selumetinib_30min_R1 1 RSSSSGDQSSDSLNSPTLLAL 21 1 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 1 RSSSSGDQSSDS(0.004)LNS(0.991)PT(0.005)LLAL 65.085 0.018592 6042500.0 260.77 422.45 512.75 473.07 388.37 386.59 467.19 387.87 223.72 317.57 True False 266.84543362990877 372.98935760832296 443.1213663341416 390.4572051237171 353.24200207229245 382.70125559563564 431.94948216317306 377.58242762067823 379.6365001376927 358.33320289375285 0.7446852021386069 1.0409009117665151 1.2366182166644735 1.0896484109497637 0.9857919925355899 1.0680038927598567 1.2054408541405741 1.0537187862343664 1.059451083717342 1.0 8.485157918589424 -4.778043715324224 4.298319756815163 1.0920006112095317 0.7178960136043563 0.6463970169904861 0.07542514709431469 0.12622234654172165 4.796060541913914 0.01931561686091418 0.14405357117151488 1.667079398803899e-05 4.778043715324224 -0.37410459760517545 RSSSSGDQSSDSLNS(ph)PTLLAL ddPTM_A459_Selumetinib_30min_R2 1 RSSSSGDQSSDSLNSPTLLAL 21 1 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 1 RSSSSGDQSSDS(0.002)LNS(0.996)PT(0.002)LLAL 84.436 0.0021116 2816100.0 10770.0 9456.1 12741.0 11063.0 13209.0 10068.0 8237.8 8797.8 7645.9 10255.0 True False 10171.446515725955 10181.352463846199 11921.25793135192 9556.200315260523 11549.567330041737 11454.775611795649 8620.874022891021 8823.400141445802 9175.293644295582 9958.91150431013 1.0213411888762984 1.022335870686249 1.1970442679596565 0.9595627304374261 1.1597218556509097 1.1502035746414778 0.865644204104031 0.8859803742233386 0.9213149087954636 1.0 13.281772350936347 -7.265829988076204 24.992201222811865 0.9087332311092728 1.084967873269424 0.5382867410408873 0.07547505205609753 284.41018068618325 1618908.6143287278 0.030482529308638907 0.02134806834558675 5.422131073568147e-08 7.265829988076204 0.17623464216015106 RSSTS(ph)GDTEEEEEEEVVPFSSDEQK ddPTM_A459_Selumetinib_30min_R2 1 RSSTSGDTEEEEEEEVVPFSSDEQK 25 1 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.005)S(0.022)T(0.022)S(0.658)GDT(0.292)EEEEEEEVVPFSSDEQK 114.63 4.0185000000000005e-08 6242900.0 33346.0 29476.0 31451.0 32910.0 35224.0 21353.0 25999.0 32083.0 26200.0 30440.0 True False 31492.762814614463 31736.71441972172 29427.47690125964 28427.60122708342 30798.84621344463 24294.181926765224 27208.00501604114 32176.356218373414 31440.73208916471 29561.1181073818 1.0653441016749061 1.0735965501858553 0.9954791559088968 0.9616551418596266 1.0418701383880928 0.8218289253645872 0.9203983732011457 1.0884688495709691 1.0635839948595702 1.0 14.85141321796004 -5.31223813629087 4.376512082756052 0.9818184212955527 1.0703022992480116 0.17381215739958222 0.07201796915169259 0.36481618351274875 15.08381328539437 0.020776942916965035 0.04808827829433232 4.872612373360508e-06 5.31223813629087 0.08848387795245882 RSSTSGDT(ph)EEEEEEEVVPFSSDEQK ddPTM_A459_Selumetinib_30min_R2 1 RSSTSGDTEEEEEEEVVPFSSDEQK 25 1 O15231-3;O15231-2;H7BZT5;O15231-4;O15231-7;O15231;O15231-8;O15231-6;O15231-5 O15231-3;O15231-5 ZNF185 Zinc finger protein 185 1 RS(0.244)S(0.16)T(0.16)S(0.16)GDT(0.276)EEEEEEEVVPFSSDEQK 78.122 0.00030714 5441200.0 16728.0 15584.0 15281.0 17955.0 20167.0 12906.0 15200.0 15008.0 12332.0 19622.0 True False 15798.324727489678 16779.242689542112 14297.83709669482 15509.498025897388 17633.441164732492 14683.684350996687 15906.830118228609 15051.670795291842 14798.744584869424 19055.461875921348 0.8290706795962045 0.8805476770282075 0.7503275013638843 0.8139135187006581 0.9253746395417614 0.7705761448664292 0.8347648680365298 0.7898874817781912 0.7766143209348942 1.0 14.217916956895309 -11.492118954832902 2.4759432380365807 1.1510765759586397 0.8199594794091993 0.5391599212858607 0.05019213887455039 7035659.573661615 3241594.357651793 6094186.930536319 0.012708272383689774 3.2201866496815984e-12 11.492118954832902 -0.3311170965494403 RST(ph)DSSSVSGSLQQETK ddPTM_A459_Selumetinib_30min_R1 1 RSTDSSSVSGSLQQETK 17 1 Q9H8G2;A0A3B3ISJ3 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 RS(0.118)T(0.882)DSSSVSGSLQQETK 176.68 5.3949e-08 0.0 738.96 706.06 798.72 883.98 662.72 805.79 797.93 557.33 451.55 605.16 True False 756.176330234142 623.3941669616112 690.2582110549108 729.609487359721 602.777093012719 797.6844841987817 737.7414976828712 542.5477979370218 766.2473700928618 682.8381807575755 1.1074019460880196 0.9129456795605452 1.0108664549031268 1.06849544726725 0.882752473424915 1.16818963361684 1.0804045796976132 0.794548127544789 1.1221507403741657 1.0 9.415399918394623 -9.352771718409633 0.007838527694211613 0.7301375081442554 1.2772943213921566 0.0 0.11286555918971782 91567.07131368862 240.49368060091365 8605.811298153403 8178.5863007538765 4.438418826914984e-10 9.352771718409633 0.5471568132479012 RST(ph)GVVNIPAAECLDEYEDDEAGQK ddPTM_A459_Selumetinib_30min_R2 1 RSTGVVNIPAAECLDEYEDDEAGQK 25 1 Q96IZ0;H0YI16 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 RS(0.417)T(0.583)GVVNIPAAECLDEYEDDEAGQK 78.352 0.00030075 2414700.0 6516.1 6265.4 7814.7 8331.5 8700.8 4912.4 7261.4 5115.1 4973.3 4623.2 True False 6153.961248015035 6745.93603356373 7311.910710002032 7196.735327360853 7607.727717861091 5589.038509672716 7599.0694881911295 5129.984094149608 5968.098965612321 4489.716203483822 1.3706793412108838 1.5025306116963877 1.6285908459711353 1.6029376916466354 1.6944785311726005 1.2448534063992438 1.6925500730524095 1.1426076530558804 1.3292820069520963 1.0 12.132408539257373 -8.2416060527269 0.8435416494707922 1.0161036958889704 1.5473301580269823 0.5162307222726228 0.15983507857434973 0.43765841765064245 0.6630339477174552 0.1451890273966717 0.054786409273626234 5.733158483417756e-09 8.2416060527269 0.5312264621380118 RST(ph)QGVTLTDLQEAEK ddPTM_A459_Selumetinib_30min_R1 2 RSTQGVTLTDLQEAEK 16 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RS(0.225)T(0.774)QGVT(0.001)LTDLQEAEK;RS(0.013)T(0.987)QGVTLTDLQEAEK 174.87 0.00020742 24263600.0 15667.1 1486.23 7930.0 2690.1000000000004 5631.3 5585.5 6758.799999999999 12230.9 10365.7 6272.7 True False 16032.112947130197 1312.2215006704182 6853.149556372001 2220.3245344310794 5121.949909286764 5529.314941228235 6248.978274458901 11906.496800437659 17589.835819226177 7077.862146272131 2.265106696882224 0.18539800204523024 0.9682513469100998 0.31369988402508114 0.7236577660649218 0.7812125790187214 0.882890644846792 1.6822165442581756 2.485190507488287 1.0 12.789097947693056 -7.783843630005599 4.397703066283118 1.8429889745956212 0.8150431776179737 0.2730584877298746 0.6253433999929296 0.22255912358465932 9.946264431395676 0.3289216491689404 0.15967839615501014 1.644963894435142e-08 7.783843630005599 -1.0279457969776473 RST(ph)QGVTLTDLQEAEK ddPTM_A459_Selumetinib_30min_R2 2 RSTQGVTLTDLQEAEK 16 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 RS(0.003)T(0.997)QGVTLTDLQEAEK;RS(0.228)T(0.772)QGVTLTDLQEAEK 227.09 5.6349e-13 11528400.0 109616.0 23152.6 71237.0 132784.0 52814.0 94320.0 101273.0 78129.0 45900.0 23072.4 True False 103523.9815476153 24928.3299726574 66653.68897698105 114698.59013482358 46179.033156849415 107311.72384828808 105982.39516864257 78356.34245504772 55081.28255315495 22406.23986270551 4.620319258472625 1.112561952625966 2.9747824438818062 5.119046785075965 2.0609898599591885 4.789367805836315 4.73003930235733 3.4970768382011927 2.4583010309032725 1.0 14.451612940643086 -6.746962997140587 24.985238242167974 3.5407174762993194 3.159416894563458 0.0 1.4834764502497015 1574.8027582703673 2717995.920487784 0.4870782589775176 0.48496248935045405 1.7907584241511197e-07 6.746962997140587 -0.38130058173586123 RST(ph)SS(ph)S(ph)SDT(ph)MSTFK ddPTM_A459_Selumetinib_30min_R1 1 RSTSSSSDTMSTFK 14 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 4 RS(0.163)T(0.733)S(0.268)S(0.785)S(0.499)S(0.498)DT(0.415)MS(0.336)T(0.302)FK 46.964 0.04598 0.0 0.0 0.0 0.0 0.0 0.0 0.0 74.52600000000002 80.122 0.0 83.29799999999999 True False 0.0 0.0 0.0 0.0 0.0 0.0 68.90444381877322 77.99690428706522 0.0 93.99010969122966 0.0 0.0 0.0 0.0 0.0 0.0 0.733103132288426 0.8298416135835536 0.0 1.0 6.554437049016823 -7.255300492626981 24.29487723261641 0.6265563318862009 3.788162543026281e-08 0.6273853388322115 0.24180781187903688 218.03699126099477 862892.1379222297 0.08984659172395612 0.06773503214005124 5.55519754678691e-08 7.255300492626981 -0.6265562940045755 RST(ph)SS(ph)SSDT(ph)MST(ph)FK ddPTM_A459_Selumetinib_30min_R2 1 RSTSSSSDTMSTFK 14 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 4 RS(0.103)T(0.457)S(0.457)S(0.377)S(0.377)S(0.377)DT(0.817)MS(0.214)T(0.821)FK 45.115 0.037654 1729800.0 2420.7 1187.9 2229.8 2200.2 3069.7 2623.3 2173.0 1998.2 677.55 1217.6 True False 2286.1671848298815 1279.0081102994786 2086.3370956226754 1900.528964443298 2684.0568425338106 2984.635763053587 2274.0488057178127 2004.014431180182 813.0789323287613 1182.4447242952729 1.9334241490167061 1.0816641860884928 1.7644267446549053 1.6072877872375788 2.2699216186477433 2.5241228631912627 1.9231755692200552 1.6948060150334368 0.6876253203407453 1.0 10.207557028185317 -8.17971868573632 4.582046732532099 0.8457494095825282 1.8628453836852177 0.5467417444314709 0.368254651909994 0.17842289663174107 6.5398526816702 0.306023158782416 0.10571357383906463 6.6112155084520484e-09 8.17971868573632 1.0170959741026895 RSTAPSAAASASASAAAS(ph)SPAGGGAEALELLEHCGVCR ddPTM_A459_Selumetinib_30min_R1 1 RSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCR 38 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 RSTAPSAAASASAS(0.002)AAAS(0.499)S(0.499)PAGGGAEALELLEHCGVCR 53.622 0.00050745 16117000.0 548.34 423.01 922.13 1173.0 1019.4 744.76 579.13 483.11 319.48 263.66 True False 561.1152551160953 373.4837925479864 796.9098108975173 968.1575699370496 927.1954499896876 737.268390587976 535.4457578397618 470.2963534375584 542.1342261040139 297.503329265884 1.8860805911002652 1.2553936571721431 2.6786584636345525 3.254274741482943 3.116588484161253 2.4781853447060627 1.7997975322192927 1.5808103882334916 1.8222795268939627 1.0 8.216762003030619 -7.389635960848949 3.1976291102604932 1.5423202753024485 2.4696015856617475 0.3766188377257649 0.571968744469229 0.34508541352862127 6.641839171403968 0.30713134299903455 0.19320214981544162 4.077218997907389e-08 7.389635960848949 0.927281310359299 RSTAPSAAASASASAAASS(ph)PAGGGAEALELLEHCGVCR ddPTM_A459_Selumetinib_30min_R1 1 RSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCR 38 1 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 RSTAPSAAASASASAAAS(0.204)S(0.796)PAGGGAEALELLEHCGVCR 96.751 3.6525e-14 21024000.0 415.3 258.89 632.35 856.75 658.96 594.78 397.62 266.29 348.53 212.69 True False 424.9756819668715 228.57903844530426 546.4803432499162 707.1346956893152 599.3571843488371 588.797053217031 367.6272032743014 259.22712416817603 591.4299543759606 239.99083327604075 1.7707996433266209 0.9524490386780295 2.277088402878068 2.9465071062775103 2.497416989504129 2.453414762470484 1.5318385217299177 1.0801542735176448 2.4643856029938016 1.0 7.906835491276177 -7.28332965351233 21.193814261419966 1.5257732144076357 2.153022131635879 0.2007638799254967 0.6162278964737333 221.72778555891844 214669.02741841605 0.27894993260520723 0.18844479995764044 5.2079924562545394e-08 7.28332965351233 0.6272489172282434 RSTRTRLSTET(ph)GEIET(ph)GVLT(ph)AVS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 RSTRTRLSTETGEIETGVLTAVSK 24 3 A0A2R8Y829 A0A2R8Y829 4 RS(0.009)T(0.009)RT(0.021)RLS(0.02)T(0.504)ET(0.562)GEIET(0.909)GVLT(0.982)AVS(0.983)K 43.497 0.037025 2738000.0 2671.4 5519.9 9758.9 14413.0 16395.0 12109.0 3657.3 6653.2 7502.5 10905.0 True False 2522.934282461497 5943.258580724042 9131.02299868693 12449.92453618819 14335.313526840353 13776.904835442328 3827.371696802467 6672.559710503451 9003.209637364813 10590.144315407308 0.2382341738998731 0.5612065712907576 0.8622189393021262 1.1756142471141908 1.3536466642842915 1.3009175725205833 0.3614088328554815 0.6300725950255209 0.8501498534128843 1.0 13.370434629097245 -5.042788714019217 2.2377235111956115 0.9470694799512146 0.22272723331232874 0.39504055617943645 0.28340180251806446 0.45680254053461045 3.831172062177813 0.08804919070504409 0.5278127149904724 9.061733505904577e-06 5.042788714019217 -0.7243422466388858 RSTS(ph)PIIGSPPVR ddPTM_A459_Selumetinib_30min_R1 1 RSTSPIIGSPPVR 13 1 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 RS(0.01)T(0.017)S(0.971)PIIGS(0.002)PPVR 95.195 0.027285000000000004 11402000.0 2454.5 2848.6 3897.5 3963.1 3304.5 2804.3 3084.3 2605.7 1672.4 2362.2 True False 2511.685074374394 2515.0845877217876 3368.24090743504 3271.0189816006123 3005.608558456859 2776.091288100676 2851.648767815824 2536.5883714935458 2837.9406527368 2665.4113797764976 0.9423254862013105 0.94360090408734 1.263685198086562 1.2272098057429681 1.1276340234987996 1.041524512562657 1.069871911500184 0.9516686207388542 1.0647289473847634 1.0 11.380142500483704 -7.186257359853055 1.9919128235625383 1.011307921088162 1.1057161263951607 0.11763687775052523 0.10165312067623064 0.7841079291122071 6.09386470852416 0.05544160908356087 0.03740911999267687 6.512423580536243e-08 7.186257359853055 0.09440820530699878 RSVSDNDIR ddPTM_A459_Selumetinib_30min_R1 1 RSVSDNDIR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 120.45 0.0088958 5090100.0 3166.3 3339.3 3523.7 3912.5 3463.9 3256.2 3413.3 3118.0 1958.2 2545.5 False True 3240.068629452695 2948.333203601547 3045.2008942986163 3229.2553217209766 3150.590856601215 3223.4455843930473 3155.832032936404 3035.3005113086224 3322.9223787306864 2872.2397202696948 1.1280634435166372 1.0264927341526728 1.0602182237117315 1.124298678460501 1.0969108303764366 1.1222759582512756 1.0987356001887199 1.0567713028575543 1.1569098342594726 1.0 11.487960447754688 -1.8987302503489456 13.52668681915925 1.0888259207034372 1.0979938132448885 0.0 0.0472622055507224 0.0 0.0 0.010230014474669723 0.0 0.012626115262855484 1.8987302503489456 0.009167892541451339 RSVSDNDIR ddPTM_A459_Selumetinib_30min_R2 2 RSVSDNDIR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 ; 109.83 0.015159 3884900.0 18323.2 19465.4 19750.3 22794.0 22001.4 14360.3 17259.4 19532.0 14558.599999999999 22810.7 False True 17304.869897581244 20958.33358887405 18479.58720050072 19689.417878156786 19237.38743698842 16338.300975175694 18061.99629885228 19588.83488630334 17470.726801271507 22152.09582168378 0.7811843193925794 0.9461106415203747 0.8342139429720148 0.8888286705081703 0.868422906430268 0.7375510248191867 0.8153628642745455 0.884288107273743 0.7886715072878173 1.0 14.435155578939746 -11.057034233347327 3.1919118940708016 1.0051475223047512 0.8414317679963267 0.4102385137716801 0.05805653669403403 44554871.9809143 45902370.984826006 1944414.282809665 0.014253391782761577 8.769316941071956e-12 11.057034233347327 -0.16371575430842455 RSY(ph)DVPPPPMEPDHPFYSNISK ddPTM_A459_Selumetinib_30min_R2 2 RSYDVPPPPMEPDHPFYSNISK 22 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 RS(0.241)Y(0.759)DVPPPPMEPDHPFYSNISK;RS(0.079)Y(0.921)DVPPPPMEPDHPFYSNISK 105.38 2.1218000000000006e-05 13016300.0 41616.0 42406.0 42844.0 46441.0 48075.0 37700.0 36227.0 37282.0 31295.0 41470.0 True False 39303.14932204748 45658.40384321887 40087.46368502016 40115.655684806494 42035.388704046934 42892.83279347395 37911.62728243865 37390.484447632625 37554.87445535914 40272.65334800011 0.9759264924122321 1.13373219908507 0.9954016026364166 0.9961016310041213 1.0437700327518737 1.065061008591428 0.9413739629927138 0.9284335979687663 0.932515524389308 1.0 15.297512906362456 -7.271522223049915 24.60331707531594 0.9446168948931778 1.0363174710688494 0.44906401915859095 0.045602633629982216 497.49089874758425 1213930.7444603154 0.01855107561932196 0.012665044701780965 5.35152769055437e-08 7.271522223049915 0.09170057617567162 RSYS(ph)PDGK ddPTM_A459_Selumetinib_30min_R1 1 RSYSPDGK 8 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 RSYS(1)PDGK 114.71 0.018317 16513000.0 5283.4 8318.1 5966.4 4970.5 5159.0 6537.8 5064.6 6243.4 6755.8 6026.1 True False 5406.492940293208 7344.212985020219 5156.195651089268 4102.495482840669 4692.369360895428 6472.035667847451 4682.573144467148 6077.804750578653 11464.0991758905 6799.608634184728 0.7951182532936245 1.080093484806981 0.7583077098241692 0.6033428839147531 0.6900940353103194 0.9518247322808524 0.6886533323294111 0.8938462605072242 1.6859939729847473 1.0 12.731235996058954 -8.097610547928747 7.045317066396489 1.3375689687611862 0.7988690057988408 0.537058148440349 0.20052541260102327 0.1887254429821348 11.72126169002676 0.1320653489824248 0.049368245203720997 7.98710607189075e-09 8.097610547928747 -0.5386999629623455 RSYS(ph)SPDITQAIQEEEK ddPTM_A459_Selumetinib_30min_R1 2 RSYSSPDITQAIQEEEK 17 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RS(0.065)Y(0.007)S(0.806)S(0.122)PDITQAIQEEEK;RS(0.137)Y(0.019)S(0.422)S(0.422)PDITQAIQEEEK 169.84 4.894600000000001e-07 24156000.0 7686.799999999999 8636.0 8569.3 10332.4 7785.0 7245.5 7011.7 6928.700000000001 3894.8999999999996 6143.3 True False 7865.887484090892 7624.893105232518 7405.636127795535 8528.040303169286 7080.848124553384 7172.61684838764 6482.801823847945 6744.928368410533 6609.360827759244 6931.852395809401 1.134745380447823 1.0999791498506357 1.0683487911936145 1.2302685943406482 1.0214943596943953 1.034733061068033 0.9352192536250591 0.9730340438997415 0.9534768558769201 1.0 12.75902521929563 -6.658111768027712 2.1871961518910523 0.9685471109697076 1.1254052369164027 0.6900226296313107 0.04797051239209119 0.1732086553342355 1.6951304112332855 0.017678298887736338 0.01742536052190026 2.1972943144681072e-07 6.658111768027712 0.15685812594669513 RSYS(ph)SPDITQAIQEEEK ddPTM_A459_Selumetinib_30min_R2 2 RSYSSPDITQAIQEEEK 17 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RS(0.066)Y(0.241)S(0.66)S(0.033)PDITQAIQEEEK;RS(0.009)Y(0.147)S(0.741)S(0.104)PDITQAIQEEEK 185.3 2.9792e-08 17294500.0 133716.0 138796.0 137494.0 155580.0 144204.0 101868.0 104461.0 115335.0 96058.0 129644.0 True False 126284.6000275592 149441.20690051917 128647.78573214846 134389.7356095301 126087.80431988338 115899.39233436613 109318.64348554467 115670.60575526301 115272.28408477036 125900.84086443546 1.0030481064343084 1.1869754473000775 1.0218183202657938 1.06742524264977 1.0014850056136577 0.9205609076047517 0.8682916073869135 0.918743711011526 0.9155799380950166 1.0 16.941928392973487 -6.505858978102206 2.0259162179155994 0.9146852259773031 1.078070396508685 0.6044762016352683 0.05499161462742913 0.2006862274549832 1.6528894721104235 0.019371030149645623 0.021201361513882036 3.1199024985199326e-07 6.505858978102206 0.16338517053138202 RSYS(ph)SPDITQAIQEEEKR ddPTM_A459_Selumetinib_30min_R1 2 RSYSSPDITQAIQEEEKR 18 2 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RS(0.008)YS(0.849)S(0.143)PDITQAIQEEEKR;RS(0.047)YS(0.811)S(0.142)PDITQAIQEEEKR 140.27 0.00012505 51633000.0 5978.1 6630.1 8239.8 9167.5 6871.700000000001 7473.7 6442.5 6603.8 4126.7 5535.5 True False 6117.378098642315 5853.844809750136 7120.880417981588 7566.568220288064 6250.155948297173 7398.5213635766595 5956.537038113494 6428.645771834471 7002.708497757085 6246.035345336041 0.9794017741526558 0.9372096835989318 1.1400640605242172 1.2114193727606863 1.0006597149605003 1.1845148089181383 0.9536508695169781 1.0292362140785491 1.1211445517973344 1.0 12.608725018029018 -5.250780450761579 24.934800189782216 1.0821982059379602 0.9583057146961718 0.265172472139647 0.08102877548185268 923.133294526199 2159508.294619499 0.02072881675827165 0.05365452744902404 5.61331674769817e-06 5.250780450761579 -0.12389249124178847 RSYS(ph)SPDITQAIQEEEKR ddPTM_A459_Selumetinib_30min_R2 3 RSYSSPDITQAIQEEEKR 18 2 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 RS(0.145)Y(0.011)S(0.422)S(0.422)PDITQAIQEEEKR;RS(0.177)Y(0.031)S(0.723)S(0.068)PDIT(0.001)QAIQEEEKR;RS(0.028)Y(0.02)S(0.924)S(0.028)PDITQAIQEEEKR 84.948 0.0088387 30184300.0 46925.0 47665.0 45989.0 55806.0 49195.0 37918.0 37213.0 34360.0 31477.8 53812.0 True False 44317.09635565838 51320.75223286866 43030.11780903721 48205.126529280424 43014.68429111994 43140.86031466699 38943.47823616059 34459.9819113958 37774.239563217896 52258.30773963303 0.8480392548579987 0.9820592065201276 0.8234120022298942 0.9224394859751907 0.8231166708541794 0.825531139079513 0.7452112385687837 0.6594163378402154 0.7228370224198759 1.0 15.673372786733816 -6.721904304566731 1.6147202126301787 0.7568173384367916 0.8955638025151293 0.18712193714843828 0.09391513386918512 0.47122806739232753 2.5479223136635265 0.0384637352569184 0.0360999182346673 1.8971239004881052e-07 6.721904304566731 0.1387464640783378 RT(ph)ALHLACANGNSEVVSLLLDR ddPTM_A459_Selumetinib_30min_R2 1 RTALHLACANGNSEVVSLLLDR 22 1 Q6S8J7-2;Q6S8J7 Q6S8J7-2 POTEA POTE ankyrin domain family member A 1 RT(0.999)ALHLACANGNS(0.001)EVVSLLLDR 44.382 0.028091 5482900.0 25134.0 31970.0 29461.0 30345.0 35911.0 15003.0 15466.0 13677.0 17335.0 26266.0 True False 23737.15289937385 34421.99620024778 27565.511334711475 26211.958651955232 31399.539131586695 17069.527066325994 16185.199645297607 13716.797805650756 20802.484380369075 25507.632332736222 0.9305902088336847 1.349478295406938 1.080676990131075 1.0276123753875457 1.230986032807477 0.6691929240496048 0.6345237940616579 0.5377526862046997 0.8155396043431044 1.0 14.638641370988989 -6.767541005101481 24.97813962640487 0.696456392363634 1.12865553375882 0.6052808568164163 0.1571818070617266 88.27856785668607 361382.45953015966 0.052284470490732864 0.04727725780869617 1.7078864576751491e-07 6.767541005101481 0.432199141395186 RT(ph)FSLTEVR ddPTM_A459_Selumetinib_30min_R1 2 RTFSLTEVR 9 1 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 RT(0.998)FS(0.002)LTEVR;RT(0.986)FS(0.014)LTEVR 112.94 0.011737 16013900.0 9454.0 15584.6 13229.7 15711.2 13477.2 13356.9 18221.2 16400.5 10316.3 16963.2 True False 9674.259805718282 13759.94778691603 11433.179405540306 12967.533855750187 12258.189639592916 13222.541713094857 16846.760214027716 15965.505463668076 17506.00762725942 19140.59195556036 0.5054315889591857 0.7188883091423278 0.5973263226176742 0.6774886526946261 0.6404289725235953 0.6908115351810578 0.880158787833817 0.8341176438396453 0.9146011611293927 1.0 14.22434782787628 -7.495610608880729 0.6506942492794648 0.9904285421101278 0.6061651483131518 0.8434848221499138 0.05845310137944475 0.27406246994194833 0.2290908831811501 0.05156191636930128 0.03088692211516987 3.1944006909127047e-08 7.495610608880729 -0.38426339379697594 RT(ph)FSLTEVR ddPTM_A459_Selumetinib_30min_R2 2 RTFSLTEVR 9 1 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 RT(1)FSLTEVR;RT(1)FSLTEVR 124.6 0.0065627 10932100.0 40549.0 39489.0 41736.0 49270.0 39739.0 37221.0 34635.0 29548.0 30422.0 47709.0 True False 38295.44891050806 42517.679322852215 39050.751198720944 42559.3410045093 34746.631548832476 42347.85489140304 36245.596127950506 29633.979788065262 36507.250061701074 46331.51720713139 0.8265528784499547 0.9176837255894538 0.842855005678731 0.918582933821095 0.7499566956439805 0.9140183064172313 0.7823097172904917 0.6396073682539362 0.7879571458558203 1.0 15.499706306284219 -7.384144455090937 7.375911704133498 0.771050584666939 0.8606358961412897 0.04644868634105681 0.09653893138400131 0.48582872463380844 27.209924056301645 0.0385640145700452 0.025869219017846987 4.129101369190969e-08 7.384144455090937 0.08958531147435067 RT(ph)GSNISGASSDISLDEQYK ddPTM_A459_Selumetinib_30min_R2 3 RTGSNISGASSDISLDEQYK 20 1 P22059 P22059 OSBP Oxysterol-binding protein 1 1 RT(0.5)GS(0.5)NIS(0.001)GASSDISLDEQYK;RT(0.498)GS(0.498)NIS(0.003)GASSDISLDEQYK;RT(0.498)GS(0.498)NIS(0.002)GAS(0.001)S(0.001)DISLDEQYK 137.85 0.00011257 11213700.0 82316.0 67346.0 77204.0 81929.0 85679.0 66022.0 59094.0 62510.0 51999.0 70646.0 True False 77741.20625705646 72511.22164847932 72236.77869335964 70770.12886459172 74915.23804002166 75115.93121195587 61841.98809253957 62691.89375091245 62400.252973453236 68606.26641964843 1.1331502253967844 1.0569183462767846 1.0529180855215794 1.0315403032094395 1.0919591161218822 1.0948844053470184 0.9014043661007093 0.9137925297878893 0.9095415948124262 1.0 16.06605273611754 -7.261153036020226 24.999961518104172 0.9240006618666713 1.0735203345280702 0.7907128749584915 0.03662554322629131 11.361140490879741 991982.266093908 0.014500845691709846 0.010513263871947016 5.480837979648603e-08 7.261153036020226 0.14951967266139887 RT(ph)PSDDEEDNLFAPPK ddPTM_A459_Selumetinib_30min_R1 1 RTPSDDEEDNLFAPPK 16 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 RT(0.5)PS(0.5)DDEEDNLFAPPK 85.054 0.044752 0.0 2168.9 2941.7 2432.3 2919.4 2862.5 2266.1 2210.5 2176.8 1571.6 1987.7 True False 2219.431150055254 2597.2843964407725 2102.0070196675442 2409.581593925166 2603.5873804154226 2243.3050914541755 2043.7602053162395 2119.064192757091 2666.890414877515 2242.840656837585 0.9895625635682302 1.1580334022047536 0.9372074709183235 1.0743436394285302 1.1608436704935126 1.0002070742810796 0.9112373627995269 0.9448126358405597 1.1890681608375346 1.0 11.131111412105403 -6.925965798680497 24.999999959849532 0.9993887286490857 1.0645306323928423 0.07546903628786683 0.09309916467658008 98.12446817346925 33131.98034097623 0.032753410372140725 0.02888578945500805 1.1858621328506431e-07 6.925965798680497 0.06514190374375661 RT(ph)PSDDEEDNLFAPPK ddPTM_A459_Selumetinib_30min_R2 4 RTPSDDEEDNLFAPPK 16 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 RT(0.561)PS(0.439)DDEEDNLFAPPK;RT(0.674)PS(0.326)DDEEDNLFAPPK;RT(0.592)PS(0.408)DDEEDNLFAPPK;RT(0.616)PS(0.384)DDEEDNLFAPPK 181.14 1.2252e-06 222581000.0 373009.0 345211.0 365038.0 391046.0 394022.0 266730.0 284255.0 312896.0 241152.0 351973.0 True False 352278.6530533353 371687.5736716837 341551.85250332294 337784.860208024 344521.4337586273 303469.6363661354 297473.420740597 313806.47555727855 289389.1383498562 341810.62495432026 1.030625227347494 1.087407899392701 0.9992429361988618 0.9882222363718673 1.0079307330036018 0.8878297343936902 0.8702872263855213 0.9180711559192047 0.8466358773620051 1.0 18.38283771735685 -6.428362712503519 1.2431763213358988 0.8959819036920541 1.0436451841385683 0.6013081873993062 0.04690799964572724 0.28374262938282735 0.907529713132411 0.019505217511473473 0.024018847008541323 3.7293855820969557e-07 6.428362712503519 0.14766328044651422 RT(ph)PSEADR ddPTM_A459_Selumetinib_30min_R2 1 RTPSEADR 8 1 G3V3Z8;P49757-3;P49757;P49757-9;P49757-8;P49757-7;P49757-6;P49757-5;P49757-4;P49757-2 G3V3Z8 NUMB Protein numb homolog 1 RT(0.992)PS(0.008)EADR 84.81700000000002 0.045109 30602000.0 5020.0 4542.0 5344.2 5278.5 4386.1 4863.5 13415.0 42125.0 11513.0 18102.0 True False 4741.00849665221 4890.3567951681425 5000.359990325005 4559.5591940796085 3835.0789057684965 5533.40297854272 14038.824081318204 42247.57677583084 13815.921700097451 17579.34822535564 0.2696919382832407 0.27818760584732705 0.2844451299458712 0.25937020733812594 0.21815819657278054 0.31476724322245325 0.7985975305426428 2.403250463796769 0.7859177441044147 1.0 14.101593961436992 -7.528004929882132 24.86713744391896 1.476935511845175 0.29280772266100835 0.6171642193111377 0.3963613613847588 76.99014510192795 373470.6253766454 0.172396243460112 0.0999696707965072 2.9647977345115714e-08 7.528004929882132 -1.1841277891841666 RT(ph)PSRASLTRT(ph)LS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RTPSRASLTRTLSR 14 3 A8MUU9 A8MUU9 Putative uncharacterized protein ENSP00000383309 3 RT(1)PS(0.019)RAS(0.198)LT(0.055)RT(0.73)LS(0.998)R 98.508 0.013424 4213800.0 10949.0 8796.6 14210.0 15458.0 14424.0 8390.2 7344.9 5694.4 7504.7 11894.0 True False 10340.498412319736 9471.270934472936 13295.74407067818 13352.593733462638 12611.928167803922 9545.873891347614 7686.452403643244 5710.969761241334 9005.849698837947 11550.589315676712 0.895235570213321 0.8199816196060508 1.1510879408233228 1.1560097384243595 1.0918861214021987 0.8264404205239766 0.6654597608462299 0.49443102902899344 0.7796874646573236 1.0 13.495678839945336 -6.957073904200949 3.951616373685648 0.6966907114493704 1.0249669072205019 0.4325649691583482 0.15433637800163671 0.19579501972060387 6.539039182946023 0.060170767609230846 0.05112578875450544 1.1038907540429531e-07 6.957073904200949 0.32827619577113143 RT(ph)PTMPQEEAAACPPHILPPEK ddPTM_A459_Selumetinib_30min_R1 1 RTPTMPQEEAAACPPHILPPEK 22 1 Q9NYV4 Q9NYV4 CDK12 Cyclin-dependent kinase 12 1 RT(0.5)PT(0.5)MPQEEAAACPPHILPPEK 72.92699999999998 0.0014859 6732000.0 4566.5 5417.0 5000.7 5418.2 5225.6 4391.8 5003.4 4868.4 2849.2 4317.2 True False 4672.890565137778 4782.775121705025 4321.632406878873 4472.013082210502 4752.945402654616 4347.622479435348 4625.989509739548 4739.27421720811 4834.884302665447 4871.354673089113 0.9592589492512806 0.9818162385355702 0.8871520751204838 0.9180224767692037 0.9756927429060696 0.8924873615655569 0.9496310205649696 0.9728862986284581 0.9925133001246779 1.0 12.250107311256377 -7.884137389292987 2.316104668330802 0.9951409295983299 0.9358228616085936 0.39617313758957784 0.029876785896645358 0.3345288676718504 3.4693699903095445 0.02266327936380876 0.008657123380874996 1.3057577456210745e-08 7.884137389292987 -0.05931806798973627 RT(ph)PTMPQEEAAACPPHILPPEK ddPTM_A459_Selumetinib_30min_R2 4 RTPTMPQEEAAACPPHILPPEK 22 1 Q9NYV4 Q9NYV4 CDK12 Cyclin-dependent kinase 12 1 RT(0.803)PT(0.197)MPQEEAAACPPHILPPEK;RT(0.949)PT(0.051)MPQEEAAACPPHILPPEK;RT(0.5)PT(0.5)MPQEEAAACPPHILPPEK;RT(0.717)PT(0.283)MPQEEAAACPPHILPPEK 114.85 4.2038e-05 48697700.0 429332.0 394686.0 446827.0 448708.0 490609.0 375130.0 375861.0 404780.0 332201.0 433786.0 True False 405471.4461921684 424957.14708448545 418078.63728845416 387593.19633552496 428974.3113198908 426800.7524089093 393339.28125444206 405957.84278506355 398650.48247147247 421261.4710686187 0.9625172821136584 1.0087728792440758 0.992444517244621 0.9200774885780866 1.0183089144889201 1.0131492712263457 0.9337176748128755 0.9636719013378217 0.9463255242883032 1.0 18.684356446258874 -7.265542670042566 24.974352448696788 0.9579014355820499 0.9857006749957363 0.12986776713898773 0.031245552169922624 705.2264093794397 4292284.581924408 0.012845129165039396 0.008995239083033318 5.4257194025525003e-08 7.265542670042566 0.02779923941368645 RT(ph)PTMPQEEAAEK ddPTM_A459_Selumetinib_30min_R1 1 RTPTMPQEEAAEK 13 1 Q9NYV4-2 Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 RT(0.917)PT(0.083)MPQEEAAEK 137.73 0.00128 54586000.0 4424.3 5501.0 4507.9 4233.5 4679.9 4352.1 5048.4 5020.0 2498.7 4202.9 True False 4527.3775818108115 4856.9403626544845 3895.751940122234 3494.1986976372523 4256.603871303452 4308.321825390637 4667.595123509839 4886.853292741908 4240.11140217259 4742.383154712827 0.9546629688306923 1.024156042269131 0.8214755773688935 0.736802275068144 0.8975664201812494 0.9084718979547586 0.9842298631799361 1.0304636157214568 0.894088744803107 1.0 12.211396512870683 -7.135161691377931 3.2733142539226656 0.9798755834793965 0.8837277141921626 0.23107309633610473 0.07798073251250666 0.4257052630260606 8.533717562491063 0.0355767500480278 0.026744521859718106 7.32551747371275e-08 7.135161691377931 -0.09614786928723396 RT(ph)PTMPQEEAAEK ddPTM_A459_Selumetinib_30min_R2 3 RTPTMPQEEAAEK 13 1 Q9NYV4-2 Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 RT(0.951)PT(0.049)MPQEEAAEK;RT(0.972)PT(0.028)MPQEEAAEK;RT(0.998)PT(0.002)MPQEEAAEK 160.63 0.0038213 45516000.0 59285.0 48872.5 50381.0 58146.0 61211.0 44214.0 46252.0 51026.0 36018.6 54504.0 True False 55990.17703665865 52620.86360014421 47139.54131068527 50226.41449255524 53521.126946717 50304.07716526941 48402.80964659933 51174.47721219096 43223.3264437705 52930.327901601144 1.0578089963989237 0.9941533651174004 0.8905960567317646 0.9489156119706541 1.011161824771125 0.9503828742339552 0.9144626826529662 0.9668271337242733 0.8166079477936314 1.0 15.691806970997177 -7.017294280151179 6.108060555539542 0.9228829946034105 0.9752001571954355 0.1613966079902457 0.05964600580026493 0.3458215241381351 49.39726470863126 0.022440003235391737 0.01824743044730803 9.609609057215663e-08 7.017294280151179 0.05231716259202501 RT(ph)PVSYQNTMSR ddPTM_A459_Selumetinib_30min_R2 1 RTPVSYQNTMSR 12 1 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 RT(1)PVSYQNTMSR 105.36 0.011676 2935200.0 4500.5 4879.3 5468.2 6584.9 5435.6 3600.0 4665.7 3365.5 3162.6 6823.6 True False 4250.380226928942 5253.526620577702 5116.381965326002 5688.025260413907 4752.731333119451 4095.8673224537474 4882.664294909157 3375.29304781148 3795.2083704271863 6626.5849381580365 0.6414133775685673 0.7927954850961288 0.7720993563161329 0.8583644989835417 0.7172218235295943 0.6180962533006116 0.7368296551656924 0.5093563395491156 0.5727246245004933 1.0 12.694049842462716 -6.524234221712295 16.613920671727005 0.6606940362851117 0.7709063398516679 0.05389212782327457 0.13352129848868569 1.3873026118318825 16906.440185303865 0.041881611595524865 0.04264743106845969 2.990651297227925e-07 6.524234221712295 0.1102123035665562 RT(ph)QSGNFYTDTLGMAEFR ddPTM_A459_Selumetinib_30min_R1 1 RTQSGNFYTDTLGMAEFR 18 1 H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 H0YDJ2 PPFIBP2 Liprin-beta-2 1 RT(0.894)QS(0.106)GNFYTDTLGMAEFR 66.20100000000001 0.039803 3996800.0 581.81 522.26 965.92 992.42 893.43 692.47 486.39 570.69 352.71 445.07 True False 595.3650409948121 461.11355640791277 834.7533694187699 819.112477030628 812.6194142478782 685.5043805124541 449.7012107051643 555.5534473376257 598.5231090808401 502.19906984892276 1.1855160169331191 0.918188790247322 1.662196167885954 1.6310513623154315 1.6181221014454281 1.3650052771278038 0.8954640454440678 1.1062414900624042 1.1918044954979599 1.0 8.972115546290173 -7.1557433635224585 6.480179697621687 1.0584964329343372 1.410875733094255 0.36836701814460215 0.22335401811435085 0.30726430330830856 16.203155931832864 0.09607177278195736 0.07422780977821473 6.986451306193765e-08 7.1557433635224585 0.3523793001599178 RT(ph)SFLEGTLR ddPTM_A459_Selumetinib_30min_R1 1 RTSFLEGTLR 10 1 E9PEW5;A0A0A0MQX1;Q9HD67-3;Q9HD67 E9PEW5 MYO10 Unconventional myosin-X 1 RT(0.984)S(0.014)FLEGT(0.002)LR 89.679 0.039560000000000005 0.0 628.85 486.19 816.04 769.44 629.97 547.37 570.17 713.23 392.86 494.73 True False 643.5009814709052 429.2666487764013 705.226250186861 635.0717481776328 572.9893247302371 541.8639547721954 527.1616178534993 694.3128235024527 666.6547266408634 558.2334145782856 1.1527453654078277 0.7689734035371001 1.2633178734376198 1.1376455289001184 1.026433226257333 0.9706763167904299 0.9443390597672133 1.2437679389489207 1.1942221823902892 1.0 9.124724673196217 -7.765009849650059 24.99922168457794 1.1642462784095913 1.0369014892966606 0.1085566814890101 0.13924126609667373 186.65852730648322 1306878.5400086632 0.07215766868834958 0.036813673242429026 1.7178694260257427e-08 7.765009849650059 -0.12734478911293068 RT(ph)SFSFQK ddPTM_A459_Selumetinib_30min_R2 1 RTSFSFQK 8 1 H0Y7F8;Q9BPZ7-4;Q9BPZ7-3;Q9BPZ7-2;Q9BPZ7 H0Y7F8 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 1 RT(0.995)S(0.005)FSFQK 110.54 0.014952000000000003 87878000.0 226580.0 214580.0 200160.0 220380.0 235160.0 159610.0 169490.0 175270.0 169400.0 164440.0 True False 213987.590671605 231037.59601655192 187281.92351772997 190363.8638232949 205617.09844292645 181594.82870467825 177371.62083806365 175780.0066824897 203284.7334314695 159692.1899335694 1.3400003516804548 1.4467682866185354 1.1727682086120659 1.1920674636779962 1.2875839358735166 1.1371553535599965 1.1107094273793148 1.1007426647202514 1.2729785565345069 1.0 17.28493423102043 -1.5228787452803376 0.2008427966751872 1.0534946700229608 2.700101742299059 0.5522495457986034 0.0834956033695328 39.84147803580762 0.4826398896924454 0.15284919198782582 20.66963671982554 0.029999999999999995 1.5228787452803376 1.6466070722760984 RT(ph)SIHDFLTK ddPTM_A459_Selumetinib_30min_R2 1 RTSIHDFLTK 10 1 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 RT(0.5)S(0.5)IHDFLTK 84.734 0.020796 1598600.0 30239.0 23917.0 30247.0 34032.0 29136.0 21379.0 22271.0 24265.0 19954.0 27756.0 True False 28558.437436308017 25751.356994724007 28300.940950443583 29396.782891525472 25475.675200855156 24323.763190760736 23306.6456291493 24335.607132712987 23945.35756134321 26954.612161251305 1.059500959073798 0.9553599525257854 1.0499479933578009 1.0906030743705122 0.9451323227524602 0.9023970756933184 0.8646626221041996 0.9028364788604424 0.8883584530207391 1.0 14.71824453092648 -6.462176961305023 4.8522323100183735 0.9042238365188555 1.0333018336715667 0.6267020424282554 0.0462705114636782 0.1381716791620485 6.61190045174312 0.014684991070300626 0.016367852735232946 3.4500313279519216e-07 6.462176961305023 0.12907799715271118 RT(ph)SLPCIPR ddPTM_A459_Selumetinib_30min_R2 2 RTSLPCIPR 9 1 Q14432 Q14432 PDE3A cGMP-inhibited 3,5-cyclic phosphodiesterase A 1 RT(0.91)S(0.09)LPCIPR;RT(0.9)S(0.1)LPCIPR 91.961 0.033104 9124900.0 21860.0 13250.3 18508.0 21563.0 19856.2 10558.1 13849.7 16597.1 13899.0 13975.0 True False 20645.108712513418 14266.55540357032 17317.215429986765 18626.082201750236 17361.686639319756 12012.38243811081 14493.738492659913 16645.394813202176 16679.18837050764 13571.505438589375 1.5212099207366399 1.0512139178756568 1.2759981203519837 1.372440388874518 1.279274927743339 0.8851179032765711 1.0679536296281658 1.2264958289647419 1.2289858664523572 1.0 13.728293142187047 -6.572254380755412 24.999882553642003 1.0935830847748496 1.290095105502448 0.36397345664338765 0.14364186569496243 141.75008863268317 71769.95133491332 0.0481342393285323 0.048134249139854826 2.677599506119712e-07 6.572254380755412 0.19651202072759855 RT(ph)SMGGTQQQFVEGVR ddPTM_A459_Selumetinib_30min_R2 1 RTSMGGTQQQFVEGVR 16 1 A0A2R8Y6G0;A0A2R8Y804;A0A2R8Y543;A0A2R8Y5C3;A0A2R8Y750;A0A2R8Y5Z1;B4DGU4;A0A2R8YCH5;A0A2R8Y5A3;P35222 A0A2R8Y6G0 CTNNB1 Catenin beta-1 1 RT(0.97)S(0.03)MGGTQQQFVEGVR 137.79 0.00050716 11499000.0 12100.0 15309.0 15075.0 14121.0 13363.0 10085.0 17966.0 8620.7 10436.0 12639.0 True False 11427.530440137807 16483.151073806494 14105.090912418977 12197.695439916291 11684.220473264262 11474.117207485011 18801.454598953635 8645.784809766288 12523.491606203157 12274.079229934261 0.9310295482098669 1.3429236332129149 1.149177111226332 0.9937768211702851 0.9519427286055446 0.9348250889159745 1.5318016322642178 0.704393759222344 1.0203202514499519 1.0 13.583327180852544 -6.580749274803914 0.35476034408523294 0.9720811722431552 1.1611905301087553 0.028783827882761792 0.21824629683486177 7.671929694714212 1.8543855900919572 0.25119372325855527 0.5548154735606875 2.625733984398847e-07 6.580749274803914 0.18910935786560013 RT(ph)SPQVLGSILK ddPTM_A459_Selumetinib_30min_R1 1 RTSPQVLGSILK 12 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 RT(0.5)S(0.5)PQVLGSILK 151.49 0.00065037 257570000.0 9962.9 11648.0 14017.0 13847.0 12195.0 10166.0 11603.0 11043.0 5465.5 8177.1 True False 10195.016185571261 10284.246744991711 12113.568389869644 11428.881390382196 11091.964403202122 10063.73926998947 10727.776368371107 10750.103767280663 9274.554315673868 9226.710436699012 1.1049459344709505 1.1146168307272737 1.3128805193331121 1.2386734653473142 1.2021580691515048 1.090718012560706 1.1626870098471545 1.1651068754170926 1.005185366908726 1.0 13.171600665732717 -8.254008555343017 4.434729037606767 0.9974890312342047 1.1775165260197051 0.5425975866998785 0.06297679017488408 0.15977140606265103 8.082809465956847 0.05791243219630314 0.017689797805833 5.5717477281214856e-09 8.254008555343017 0.1800274947855004 RT(ph)SPQVLGSILK ddPTM_A459_Selumetinib_30min_R2 1 RTSPQVLGSILK 12 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 RT(0.5)S(0.5)PQVLGSILK 90.434 0.03047 152440000.0 237770.0 223320.0 263690.0 275380.0 283170.0 230880.0 245520.0 236280.0 191150.0 233460.0 True False 224555.69526872452 240447.92591302306 246724.4724839636 237872.76894300303 247595.65302808065 262681.62428003346 256937.16648865043 236967.53568174003 229385.34117724595 226719.40319807365 0.9904564501369175 1.0605529236637743 1.088237129260668 1.049194579676911 1.0920796788255853 1.1586199530109973 1.1332826518786177 1.0452018324815062 1.0117587552788465 1.0 17.790548340150508 -4.765259550871157 2.909997653644677 1.0790322858091423 0.9730467399405104 0.19995795143345163 0.04727568652507198 0.6817384577665513 7.889169623645541 0.012804964928434354 0.17599656602856426 1.7168820066144788e-05 4.765259550871157 -0.10598554586863196 RT(ph)SSEDNLYLAVLR ddPTM_A459_Selumetinib_30min_R1 1 RTSSEDNLYLAVLR 14 1 Q15149-4 Q15149-4 PLEC Plectin 1 RT(0.834)S(0.164)S(0.002)EDNLYLAVLR 206.13 9.7679e-06 59718000.0 2911.8 3046.2 4343.1 4579.1 3962.0 3145.0 2891.0 2439.0 2068.8 2287.4 True False 2979.6392746234924 2689.5494878600407 3753.3308749406333 3779.4461453527206 3603.6377995479124 3113.364155431527 2672.9295424425477 2374.3097970114595 3510.6025008262914 2581.010071162797 1.1544469771406607 1.0420530775567043 1.4542100849880382 1.4643283215280147 1.3962122193209425 1.2062580422357259 1.03561375924362 0.9199149679961478 1.3601661380750423 1.0 11.333720055535379 -7.04595865493322 4.451425835310975 1.0749365370596695 1.3055893906825684 0.2971656116759621 0.16149247176874226 0.2920055674483386 12.620188432855574 0.0666587534483136 0.05278821247593978 8.99583218256787e-08 7.04595865493322 0.2306528536228989 RT(ph)SSLDTLAAPYLAGHWPR ddPTM_A459_Selumetinib_30min_R1 1 RTSSLDTLAAPYLAGHWPR 19 1 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 RT(0.428)S(0.428)S(0.144)LDTLAAPYLAGHWPR 91.565 0.0030501 16016000.0 1256.6 1264.2 1877.6 1869.7 1736.4 1299.1 1493.5 1237.5 515.54 893.9 True False 1285.876335082038 1116.1868762893646 1622.632232918545 1543.1919936157713 1579.3429265863201 1286.0322334884243 1380.8440925762525 1204.6774800334886 874.8337264481755 1008.6407723233474 1.2748605552798484 1.1066247834878722 1.6087315498667605 1.5299718551542538 1.5658130921560829 1.2750151181437186 1.3690147478329233 1.1943573104412402 0.8673392455007001 1.0 9.978196734363834 -7.999435429725558 2.4223522659327026 0.932871620860062 1.398213757426177 0.6006841813107636 0.14769639948118757 0.2235417082885868 2.4627573032491 0.12760183747731924 0.044169569067319406 1.001300816426566e-08 7.999435429725558 0.465342136566115 RT(ph)T(ph)QIINITMTK ddPTM_A459_Selumetinib_30min_R2 1 RTTQIINITMTK 12 1 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 2 RT(1)T(1)QIINITMTK 51.286 0.047549 34115000.0 2626.6 15317.0 110250.0 90879.0 180770.0 77063.0 16357.0 30330.0 108820.0 72274.0 True False 2480.62408711289 16491.76464808244 103156.63503112379 78501.1234249808 158060.05649569555 87677.72874173701 17117.632910780605 30418.25527859819 130587.0406848433 70187.26182959642 0.03534293862518035 0.234968058564841 1.4697344267621069 1.1184525707181614 2.251976389667977 1.2491971684919791 0.24388517894229172 0.4333871201935318 1.860551861987265 1.0 16.09892160149235 -5.187019800888159 5.709892315222953 1.184054006876725 0.10197811134580724 0.36479520619760264 0.564256190139437 0.26203034712868667 15.135055696524836 0.15574336407878298 0.4273495715331441 6.501000495063684e-06 5.187019800888159 -1.0820758955309178 RT(ph)YSDEANQMR ddPTM_A459_Selumetinib_30min_R1 2 RTYSDEANQMR 11 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 RT(0.897)YS(0.103)DEANQMR;RT(0.5)YS(0.5)DEANQMR 203.74 0.0022932 36944000.0 5156.9 4303.8 7581.1 7751.4 6843.7 5151.799999999999 4892.0 4675.3 3226.3 3584.1000000000004 True False 5277.045736419354 3799.9090952176634 6551.628260001487 6397.763501798839 6224.688543353373 5099.97756946014 4522.992501428206 4551.295856485312 5474.795460371164 4044.1541470904012 1.3048577142431543 0.939605404989703 1.6200243664587088 1.5819781514514624 1.53918182071071 1.2610739808544043 1.1184025971617104 1.125401181792187 1.3537553864780474 1.0 11.98162227275479 -6.985057074789658 9.063885447936844 1.163959028289455 1.3951320280423798 0.2595322090322888 0.19706968157493712 0.3253256109406818 168.42723535885793 0.07606486136060708 0.06604458162095135 1.0350061376900442e-07 6.985057074789658 0.23117299975292482 RTADS(ph)SSSEDEEEYVVEK ddPTM_A459_Selumetinib_30min_R1 1 RTADSSSSEDEEEYVVEK 18 1 P45973;F8VNY3 P45973 CBX5 Chromobox protein homolog 5 1 RT(0.097)ADS(0.294)S(0.294)S(0.191)S(0.125)EDEEEYVVEK 123.12 0.00045927 6371200.0 1848.9 2071.1 2153.5 2489.4 2310.0 1818.4 2218.4 1977.9 905.4 1678.9 True False 1891.9757726668627 1828.6146491717323 1861.066528328764 2054.673021825483 2101.0609078636244 1800.1085469750988 2051.064301955914 1925.4396668753436 1536.3976722003697 1894.4031688708676 0.9987186485728633 0.9652721655135598 0.9824025629338587 1.0846017656580156 1.1090885733240894 0.9502246282917844 1.0826968280349858 1.0163832591258675 0.8110193740417558 1.0 10.887527684017803 -8.125065508696615 9.061330238588567 0.9060210257589131 1.0253025700782592 0.33992236803472975 0.06594061454568349 0.3527794746326524 24.171428447351975 0.0440657245388989 0.016597128250531713 7.497811043091946e-09 8.125065508696615 0.11928154431934612 RTAEY(ph)LMRAES(ph)IS(ph)SLYGK ddPTM_A459_Selumetinib_30min_R1 1 RTAEYLMRAESISSLYGK 18 2 F5H7T0;F6RJM5;Q96S38-2;Q96S38 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 3 RT(0.468)AEY(0.532)LMRAES(0.708)IS(0.431)S(0.431)LY(0.431)GK 51.495 0.02848 10580000.0 1163.0 932.15 1283.2 1098.4 542.45 1169.0 975.04 599.51 915.8 906.41 True False 1190.095637195934 823.0134446552214 1108.948488113058 906.5850595216153 493.3854932773258 1157.2409213670755 901.4919477907919 583.6090473170719 1554.0457126144229 1022.756552681067 1.1636157539897467 0.8047012189731403 1.0842741463802372 0.8864133474824305 0.482407560219447 1.1314920626355016 0.8814335585801034 0.5706236208286242 1.5194678621619464 1.0 9.998247065095278 -8.265612022322786 24.99193341416866 1.259733889892475 0.876186858380551 0.2893825525724295 0.24076821386847105 465.4102274972688 2787505.534326528 0.19745177104328474 0.05812466953689408 5.4248530411659055e-09 8.265612022322786 -0.38354703151192404 RTAFYNEDDS(ph)EEEQR ddPTM_A459_Selumetinib_30min_R1 2 RTAFYNEDDSEEEQR 15 1 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 RTAFYNEDDS(1)EEEQR;RTAFYNEDDS(1)EEEQR 183.75 3.7631e-05 10342400.0 2562.8999999999996 2771.7 3256.4 3381.2 3088.0 2573.1000000000004 2926.7 2328.6 1578.99 2536.7 True False 2622.610583464712 2447.188075471628 2814.1987661248145 2790.736892984782 2808.690945230679 2547.216950187872 2705.9366627003114 2266.8379636411973 2679.4307051332685 2862.3101545504383 0.9162566045805144 0.8549695677043041 0.983191413289319 0.9749945821028967 0.9812671560995874 0.8899164704909291 0.9453680826302042 0.7919609829973974 0.9361077453027122 1.0 11.482964292920963 -8.546134388244168 23.403316112273394 1.000000003401906 0.9178609587325831 0.15790911694238585 0.057357568177712794 5491.623872148869 5526489.703120941 0.0579125985944221 0.014952968551464958 2.843581052526216e-09 8.546134388244168 -0.08213904466932298 RTAFYNEDDS(ph)EEEQR ddPTM_A459_Selumetinib_30min_R2 2 RTAFYNEDDSEEEQR 15 1 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 RTAFYNEDDS(1)EEEQR;RTAFYNEDDS(1)EEEQR 142.23 0.00019625 22272000.0 51569.0 39137.0 52605.0 62672.0 45775.0 51887.0 42058.0 46208.0 42627.0 46287.0 True False 48703.00142706334 42138.68205471061 49220.45157199339 54135.965484769775 40024.335266307855 59033.96326671041 44013.780336345975 46342.45762985378 51153.591097894016 44950.57404193108 1.0834789647320608 0.9374448036059013 1.094990500590254 1.2043442522952057 0.890407655950558 1.3133083286465257 0.9791594718076071 1.0309647566819573 1.1379963924415424 1.0 15.456051919363903 RTAQEVETYRR ddPTM_A459_Selumetinib_30min_R1 1 RTAQEVETYRR 11 2 P17844-2;P17844;J3KTA4;J3QR02;J3KRX8;J3QRQ7;J3KTQ4 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 0 114.97 0.0040042 2391800.0 465.86 419.25 1059.3 1193.3 545.22 706.09 648.17 631.07 380.71 384.62 False True 476.7136315942374 370.1640150959629 915.4528783183928 984.9125560152434 495.90494726640895 698.9873756784247 599.2780150553392 614.3319735957449 646.0370640417528 433.9897235160599 1.0984445155337799 0.8529326733753061 2.1093883765303403 2.2694375065744996 1.1426651839788504 1.6106081268824295 1.3808576161669477 1.4155449779285187 1.4885999115549244 1.0 8.761517071135843 -9.58188533536186 0.638936825531957 0.9716753984724482 1.5158672509820341 0.11002648446920604 0.41281318279528423 12.86585698083555 5.675921699999136 1.3966642073251982 0.1742665760966027 2.618874365477947e-10 9.58188533536186 0.5441918525095859 RTAS(ph)PPPPPKR ddPTM_A459_Selumetinib_30min_R2 1 RTASPPPPPKR 11 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RT(0.476)AS(0.524)PPPPPKR 53.967 0.046428 6667900.0 5014.5 2686.1 3259.0 4927.0 3974.6 3695.2 1949.9 3162.9 896.97 3348.1 True False 4735.814164633965 2892.1152328271983 3049.319488130909 4255.934100450926 3475.275214625169 4204.180258314187 2040.574213653549 3172.103515353716 1076.3890634358045 3251.4316535914904 1.4565319739699418 0.8894897820265126 0.9378390238535905 1.308941584470913 1.0688446151978694 1.29302433703944 0.6275925287863752 0.9756020895748647 0.33105080411173293 1.0 11.66685938272568 -7.265683755840641 24.994604304451904 0.7315281843228341 1.1395058640338853 0.4339989257973432 0.23744188908759234 364.25260862523726 2145025.011072201 0.0926627200545596 0.06494444423773792 5.4239570784665425e-08 7.265683755840641 0.40797767971105126 RTCPSLSPTS(ph)PLNNK ddPTM_A459_Selumetinib_30min_R2 1 RTCPSLSPTSPLNNK 15 1 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 RT(0.021)CPS(0.069)LS(0.005)PT(0.218)S(0.688)PLNNK 60.093 0.043565 4394000.0 21364.0 17419.0 22628.0 25305.0 25867.0 17617.0 16230.0 18414.0 13656.0 22505.0 True False 20176.674406868096 18754.981289087154 21172.139115503596 21858.415346440175 22617.356206085962 20043.58183879656 16984.727159134884 18467.5816913982 16387.581580520346 21855.222174987775 0.9231969478653622 0.8581464484287561 0.9687450873747724 1.0001461056504863 1.0348719415888807 0.9171072102728588 0.7771473116650842 0.8449962916658628 0.7498245247433414 1.0 14.415690423842047 -7.062871645878753 6.230464886024018 0.831351530605421 0.9566561407198297 0.33179850355517115 0.07565086398675883 0.25050466968765606 19.37006963150144 0.02903226313384191 0.0226333973164136 8.652235946119379e-08 7.062871645878753 0.12530461011440874 RTDALTS(ph)SPGR ddPTM_A459_Selumetinib_30min_R1 2 RTDALTSSPGR 11 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RTDALT(0.012)S(0.777)S(0.21)PGR;RTDALT(0.014)S(0.952)S(0.034)PGR 124.42 0.0018374000000000003 528715000.0 4601.7 5574.0 3770.8999999999996 3786.3999999999996 4744.8 4317.9 5586.200000000001 5617.1 2448.4 5221.1 True False 4708.910656650496 4921.393488717703 3258.8324920710193 3125.176319530813 4315.633677762478 4274.465846339521 5164.828436524576 5468.116261087768 4154.755975939236 5891.27904282071 0.7993019210979179 0.8353692726055917 0.5531621348070977 0.5304750117615371 0.7325461324093346 0.7255582048092788 0.8766905113446616 0.9281713226181977 0.7052383609298472 1.0 12.524365173116614 -7.1430099009909425 2.789339316957719 0.8730647928962292 0.6832661875866992 0.38512545771210427 0.1126482180693839 0.327365930824235 4.9235024119640105 0.05129340044873619 0.03772932232083785 7.194325762834045e-08 7.1430099009909425 -0.18979860530952997 RTDALTS(ph)SPGR ddPTM_A459_Selumetinib_30min_R2 2 RTDALTSSPGR 11 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RTDALT(0.079)S(0.46)S(0.46)PGR;RTDALT(0.002)S(0.499)S(0.499)PGR 127.78 0.0014901 92658000.0 74475.0 55194.0 76508.0 77093.0 87764.0 77099.0 73396.0 79334.0 61977.0 80881.0 True False 70335.97764704643 59427.20232331802 71585.55857561207 66592.8004071571 76738.3016998851 87718.68741496142 76809.05943141492 79564.84880554937 74374.13178206721 78545.75537592464 0.895477767199695 0.756593428109462 0.9113867227197618 0.8478217580114931 0.9769885251292197 1.1167845670989422 0.9778893724276024 1.0129745194345294 0.9468892548821793 1.0 16.261245693725016 -6.323639522599562 4.093075203586718 1.0128279353192757 0.8492457963606411 0.6417425843867434 0.05607894314508095 0.13924058100830522 4.712689293336191 0.01758059233719343 0.02049693536848657 4.746357836920698e-07 6.323639522599562 -0.1635821389586346 RTDALTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 3 RTDALTSSPGR 11 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RTDALT(0.01)S(0.053)S(0.937)PGR;RTDALTS(0.003)S(0.997)PGR;RTDALTS(0.002)S(0.998)PGR 171.26 0.00056746 550506700.0 14636.9 19311.1 13669.2 13897.6 16242.2 13499.900000000001 17199.5 16647.4 8634.2 15135.0 True False 14977.911291550437 17050.147434513176 11812.997719541003 11470.645050261834 14773.095877793316 13364.103262928482 15902.127867603116 16205.85687362385 14651.606782982582 17077.724677384344 0.8770437265208613 0.9983851922084394 0.6917196489989499 0.6716729111725379 0.8650505940851126 0.7825458903565925 0.9311619766690556 0.9489470746114622 0.8579367017425561 1.0 14.059828152205744 -7.271001847975999 23.389866906539485 0.9302570530613098 0.8130037391823518 0.28363359160045176 0.09339841724797887 436.0160168658774 1066490.0319002823 0.04165629716083825 0.028545419968263548 5.357943776380542e-08 7.271001847975999 -0.11725331387895799 RTDALTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 5 RTDALTSSPGR 11 1 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 RTDALT(0.079)S(0.233)S(0.688)PGR;RTDALTS(0.058)S(0.942)PGR;RTDALT(0.011)S(0.085)S(0.904)PGR;RTDALT(0.003)S(0.199)S(0.798)PGR;RT(0.006)DALT(0.053)S(0.243)S(0.698)PGR 122.52 0.0074126 425934880.0 92309.0 82807.0 108545.8 108551.8 114076.5 91937.09999999999 93297.90000000001 108353.3 97838.5 99234.5 True False 87178.83532220496 89158.0306335289 101562.08140373112 93766.85757770028 99745.19021315068 104600.60100310066 97636.4372162816 108668.59016414553 117408.93383609706 96369.34214280483 0.9046324628118668 0.9251700660300259 1.0538837263538796 0.9729946837112569 1.0350303114588388 1.085413666600508 1.0131483212949521 1.1276261490206612 1.2183224584237042 1.0 16.55628663624119 -5.190185418316758 0.4563602395915276 1.1077622285777282 0.8107199293275457 0.5016282385518414 0.06301265490752983 2.944782152515944 0.6269725715118313 0.04809355600281291 0.45504857245218017 6.45378631316766e-06 5.190185418316758 -0.29704229925018255 RTDEAAFQK ddPTM_A459_Selumetinib_30min_R1 2 RTDEAAFQK 9 1 P26447 P26447 S100A4 Protein S100-A4 0 ; 180.09 0.0015419 7511500.0 4669.8 5401.7 4929.8 5136.4 5255.799999999999 4503.5 4338.5 4629.8 3305.9 4122.4 False True 4778.597254150968 4769.266452817799 4260.360237453051 4239.42416216936 4780.413817986858 4458.198878850834 4011.243452053613 4507.002664290142 5609.870846617189 4651.550195576426 1.0273128426509002 1.025306887444388 0.915901163767857 0.9114002824694888 1.027703371347681 0.9584329291105003 0.86234551566664 0.9689248690847737 1.2060217799975836 1.0 12.183495879756535 -8.145498462494247 8.584895648369587 1.102297394066706 0.9592433508575677 0.39564775686245535 0.06963252759220721 0.2843430905131029 18.924056440929935 0.04687132819260723 0.017627094337591704 7.1532192648059705e-09 8.145498462494247 -0.14305404320913828 RTDEAAFQK ddPTM_A459_Selumetinib_30min_R2 2 RTDEAAFQK 9 1 P26447 P26447 S100A4 Protein S100-A4 0 ; 130.41 0.005208399999999999 12438000.0 54040.0 46141.0 58526.0 68646.0 71581.0 46872.0 33307.0 42687.0 43753.0 57901.0 False True 51036.67313926007 49679.86633330098 54760.50087829077 59296.29637904491 62588.35483774066 53328.19253834781 34855.841496568435 42811.21210278675 52504.82256096275 56229.24768513516 0.9076534942286306 0.8835235820954158 0.9738793089484519 1.0545454335630486 1.113092517051168 0.9484066519432683 0.6198880997261319 0.7613691070973438 0.933763561180332 1.0 15.77903312413072 -7.0223271946170405 24.707249434826092 0.8053375588220807 0.9885765325648209 0.2962226693803245 0.11329970252503753 754.9237953802611 835395.7267344355 0.0444353026223698 0.03472059618710163 9.498888839480879e-08 7.0223271946170405 0.18323897374274023 RTES(ph)VPSDINNPVDR ddPTM_A459_Selumetinib_30min_R1 4 RTESVPSDINNPVDR 15 1 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 RT(0.004)ES(0.996)VPSDINNPVDR;RT(0.413)ES(0.587)VPSDINNPVDR;RT(0.003)ES(0.996)VPS(0.001)DINNPVDR;RT(0.038)ES(0.962)VPSDINNPVDR 188.54 1.0715e-05 79724000.0 5616.4400000000005 6793.0 6383.4 7423.6 6777.9 6019.0 6210.400000000001 6042.85 3415.31 5800.3099999999995 True False 5747.292124310174 5997.672402019976 5516.56934150631 6127.20761823076 6164.840141735436 5958.454324814739 5741.944527978274 5882.573988056867 5795.531625626956 6544.836288303877 0.8781414646812518 0.9163976206308285 0.8428888208196805 0.9361895925770594 0.9419395490078915 0.9104054039461541 0.8773243936199853 0.8988114796040776 0.8855120846924796 1.0 12.676141389895083 RTES(ph)VPSDINNPVDR ddPTM_A459_Selumetinib_30min_R2 4 RTESVPSDINNPVDR 15 1 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 RT(0.14)ES(0.86)VPSDINNPVDR;RT(0.028)ES(0.972)VPSDINNPVDR;RT(0.004)ES(0.983)VPS(0.013)DINNPVDR;RT(0.006)ES(0.994)VPSDINNPVDR 166.36 0.00014389 115589900.0 81051.0 70673.0 87470.1 100267.0 85375.3 70824.0 64158.6 77546.0 65376.0 75131.5 True False 76546.50989286024 76093.39185048839 81842.3689962441 86610.46162977735 74649.69154913399 80579.36312374001 67142.10202785417 77771.64602156858 78453.0267580623 72962.25837991982 1.049124733698304 1.0429144264458554 1.1217082751206096 1.1870583991354864 1.0231274799695425 1.1043978751885306 0.920230589330724 1.0659161016728118 1.075254912609087 1.0 16.154862765070277 -7.138353645012193 20.72721494234782 1.0196031146394575 1.089086667152535 0.2677001165491636 0.05872018047022698 7.146517545655607 1172.6772512966218 0.02312018152273292 0.017908823789225942 7.271874163145835e-08 7.138353645012193 0.06948355251307747 RTGGPAYGPSSDVST(ph)ASETESEK ddPTM_A459_Selumetinib_30min_R2 1 RTGGPAYGPSSDVSTASETESEK 23 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 RTGGPAYGPSSDVS(0.374)T(0.423)AS(0.113)ET(0.078)ES(0.013)EK 87.23700000000002 0.0027581 0.0 7391.0 6205.8 4922.9 8519.1 7076.2 6631.5 6756.6 7412.4 4607.8 7619.8 True False 6980.237808517233 6681.764905207936 4606.16597364825 7358.783883732799 6187.224493969361 7544.92893023667 7070.79528794891 7433.968856811123 5529.4887526890525 7399.796575381996 0.9433013107062197 0.9029660257738918 0.6224719729421032 0.9944575920119696 0.8361344032825606 1.0196130195440112 0.9555391443424778 1.0046180028168359 0.7472487515514717 1.0 12.853269895441308 RTGGPAYGPSSDVSTAS(ph)ETESEK ddPTM_A459_Selumetinib_30min_R1 1 RTGGPAYGPSSDVSTASETESEK 23 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 RTGGPAYGPSSDVS(0.001)T(0.207)AS(0.645)ET(0.126)ES(0.022)EK 139.47 1.6936000000000004e-06 6601600.0 1708.3 2194.5 2009.8 1726.5 2348.3 1976.5 1639.1 2117.3 868.64 1485.5 True False 1748.1000662268395 1937.5669198046285 1736.880199041166 1424.9991854188534 2135.896679626039 1956.618204518415 1515.4613673530189 2061.142326040328 1474.0186370445438 1676.1783949953387 1.042908124484984 1.1559431416069628 1.0362144054756153 0.8501476869488084 1.274265726132318 1.1673090467938265 0.9041169912927037 1.2296676369259967 0.8793924569399088 1.0 10.710959987326284 -8.288309685594621 24.993888971426326 0.9396962240349328 1.0789905317558157 0.16241116346933548 0.1295810599839701 1614.3651839428596 1501614.4687159809 0.12219427967082112 0.03158779387432486 5.148613776225676e-09 8.288309685594621 0.13929430772088292 RTGGPAYGPSSDVSTAS(ph)ETESEKR ddPTM_A459_Selumetinib_30min_R1 3 RTGGPAYGPSSDVSTASETESEKR 24 2 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 RTGGPAYGPSSDVSTAS(0.964)ET(0.007)ES(0.029)EKR;RTGGPAYGPSSDVSTAS(0.552)ET(0.074)ES(0.374)EKR;RTGGPAYGPS(0.001)S(0.002)DVS(0.005)T(0.054)AS(0.611)ET(0.177)ES(0.15)EKR 136.22 8.9896e-08 62938000.0 3329.76 4585.24 4235.969999999999 4091.04 3787.69 3896.85 4005.6400000000003 3892.35 2218.21 3444.2599999999998 True False 3407.336929414905 4048.397969179756 3660.7485405176662 3376.6166623318563 3445.0941082709833 3857.6512270567046 3703.4913498407363 3789.1122338653327 3764.1403583516462 3886.3643209334523 0.8767415116132264 1.0416928612105478 0.9419468269609895 0.8688368828789677 0.8864568073853453 0.9926118367951023 0.9529449747910427 0.9749760755716383 0.9685505648753873 1.0 11.92420543503652 -6.780496949192327 24.912972904609234 0.9746982152439082 0.9277500552269132 0.24601621012333885 0.0473650047069793 433.33138152741395 566467.9930032113 0.017675551569877674 0.015613665441385814 1.6576889816491547e-07 6.780496949192327 -0.04694816001699498 RTGGPAYGPSSDVSTAS(ph)ETESEKR ddPTM_A459_Selumetinib_30min_R2 2 RTGGPAYGPSSDVSTASETESEKR 24 2 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 RTGGPAYGPSSDVS(0.006)T(0.1)AS(0.872)ET(0.005)ES(0.017)EKR;RTGGPAYGPSSDVS(0.004)T(0.094)AS(0.809)ET(0.047)ES(0.047)EKR 86.084 3.9046e-05 37153000.0 122887.0 93115.0 105471.0 121011.0 114205.0 92520.0 109524.0 96038.0 80001.0 102196.0 True False 116057.43249563765 100256.62108808501 98685.11068814211 104529.09304438128 99857.54689434607 105263.79018706128 114617.08301768884 96317.45468005321 96003.43541470474 99245.33594290377 1.169399361622454 1.0101897498312973 0.9943551477816152 1.05323934924778 1.0061686621907806 1.0606421872320524 1.1548863423025593 0.9704985505360677 0.9673344797778295 1.0 16.59871168361712 -4.757057191688314 24.885802861363945 1.0278666719089407 1.1693995847768959 0.4069552549856813 0.052431008779278955 137.67467194614974 781728.669114112 0.01367433563354131 0.1045366422412784 1.7496162687105527e-05 4.757057191688314 0.14153291286795522 RTGGPAYGPSSDVSTAS(ph)ETESEKREEPNR ddPTM_A459_Selumetinib_30min_R1 1 RTGGPAYGPSSDVSTASETESEKREEPNR 29 3 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 RTGGPAYGPSSDVS(0.042)T(0.124)AS(0.373)ET(0.373)ES(0.088)EKREEPNR 75.17699999999998 4.383e-05 6253300.0 786.95 672.33 1008.6 1046.7 759.47 651.81 620.23 698.01 454.93 509.86 True False 805.2844038618573 593.6132910422631 871.6376598432284 863.9134939924206 690.7760725953191 645.2533831961282 573.4455517499625 679.4965073439806 771.9829832274289 575.3054974569664 1.3997509278487186 1.0318227336019263 1.5150866169298653 1.5016604183537157 1.2007117534053984 1.1215838994210099 0.9967670294908959 1.181105534968068 1.341866167870531 1.0 9.168184446049386 -6.48021109273643 8.021941904542006 1.1344499347284085 1.3500696830220078 0.3396965167609045 0.15374253772321844 0.4018003199495816 69.22414045735769 0.05003292008260612 0.05609612846618454 3.3097021133382074e-07 6.48021109273643 0.2156197482935993 RTGGPAYGPSSDVSTASET(ph)ESEKREEPNR ddPTM_A459_Selumetinib_30min_R1 1 RTGGPAYGPSSDVSTASETESEKREEPNR 29 3 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 RTGGPAYGPSSDVS(0.024)T(0.253)AS(0.115)ET(0.493)ES(0.115)EKREEPNR 68.97 0.00020623 7653300.0 1027.2 908.86 1451.3 1659.3 803.26 978.31 946.73 731.7 635.01 435.48 True False 1051.1317614167356 802.450248682449 1254.221431420263 1369.5344039186234 730.605274827071 968.469089634409 875.3173938833046 712.2929391034372 1077.565590704613 491.37809993441255 2.139150608374767 1.6330606691457297 2.552456919809149 2.7871295120833106 1.486849484998598 1.9709244057960191 1.781352066769233 1.4495821836555427 2.1929459022460356 1.0 8.940689749916634 -6.285191034734784 24.80613897524582 1.692341027951423 2.2514937398761417 0.35763152567392353 0.4109984104567164 908.1802305699574 948497.3766408951 0.12847201838195432 0.14575640348349062 5.185718826030524e-07 6.285191034734784 0.5591527119247186 RTGS(ph)NAAQYK ddPTM_A459_Selumetinib_30min_R1 1 RTGSNAAQYK 10 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 RT(0.006)GS(0.994)NAAQYK 101.72 0.028834 12806000.0 3758.5 3991.9 4945.5 5524.6 4542.4 4142.9 3420.1 3293.0 2535.0 2483.9 True False 3846.065737232088 3524.526492216039 4273.9282636869775 4559.832319585868 4131.540722025856 4101.22618745223 3162.1191034616936 3205.6589428285088 4301.709850925489 2802.732760234883 1.3722556041731815 1.257532128008047 1.5249146562688343 1.6269236882947526 1.4741115459326248 1.463295482766087 1.1282271175924359 1.1437618984978999 1.534826977426483 1.0 11.452618475031743 -7.2494994939517925 24.421397249940853 1.21368415924676 1.456390077971894 0.3846754790503607 0.1554824197816867 630.0547971611311 1288692.4110352935 0.061221309762020046 0.04701388680854865 5.629897734002751e-08 7.2494994939517925 0.24270591872513392 RTGS(ph)NISGASSDISLDEQYK ddPTM_A459_Selumetinib_30min_R1 1 RTGSNISGASSDISLDEQYK 20 1 P22059 P22059 OSBP Oxysterol-binding protein 1 1 RT(0.375)GS(0.624)NIS(0.002)GASSDISLDEQYK 140.07 3.6375e-05 12406000.0 2955.7 3427.5 2634.9 2969.5 2549.7 2898.6 2950.7 2776.3 1506.1 2557.5 True False 3024.5620592089604 3026.2067065984793 2277.0950524696814 2450.932569418642 2319.0800851860963 2869.4427157182267 2728.1263233778022 2702.6635053066484 2555.741698808235 2885.780037159594 1.0480916841416528 1.0486615984692667 0.7890743657340471 0.84931371686632 0.8036233029973805 0.9943386809697915 0.9453687697081145 0.936545221917474 0.8856328846615046 1.0 11.49474562212356 -10.052468939236913 15.355437245796775 0.9999999769178379 0.919672833326332 0.06579524007892879 0.08733958256518728 0.0 0.0 0.09067341294869247 0.02199153288368866 8.861986023614533e-11 10.052468939236913 -0.08032714359150595 RTILT(ph)T(ph)SNSFPY(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 RTILTTSNSFPYVK 14 1 A0A0J9YW64;A6NIW2;Q5JSL3 A0A0J9YW64 DOCK11 Dedicator of cytokinesis protein 11 3 RT(0.051)ILT(0.885)T(0.559)S(0.559)NS(0.163)FPY(0.784)VK 55.31399999999999 0.035735 5559300.0 1085.3 471.93 710.32 837.78 739.59 552.23 646.26 0.0 0.0 614.7 True False 1024.9833708001288 508.1255135058788 664.6187845379399 723.6729187488892 646.6760921815103 628.294669855176 676.312370539896 0.0 0.0 596.9520138175951 1.7170280811102567 0.8511999318945959 1.1133537858220897 1.2122798851467063 1.0832966087942688 1.0525044816201223 1.1329426065837016 0.0 0.0 1.0 9.221471154414173 -7.750915613293936 24.97845678226722 0.25000002978213215 1.14617133675896 0.5615260787829929 0.3344749319205304 126.97889660739548 301389.748438792 0.15024893303385745 0.08556439237121256 1.77453425283427e-08 7.750915613293936 0.896171306976828 RTIQEVLEEQS(ph)EDEDR ddPTM_A459_Selumetinib_30min_R1 2 RTIQEVLEEQSEDEDR 16 1 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 RTIQEVLEEQS(1)EDEDR;RTIQEVLEEQS(1)EDEDR 207.38 3.6794e-08 19128500.0 2809.33 3485.2 2343.2 2205.8599999999997 3110.2 2526.6 2845.48 3255.6000000000004 1606.6100000000001 2513.63 True False 2874.7819229954016 3077.1511637744757 2025.0063102762763 1820.6479601204928 2828.88295915041 2501.1846979692514 2630.8431526909076 3169.250912320831 2726.2998278482846 2836.278895329609 1.0135751909761745 1.084925452444575 0.7139658633749932 0.6419142923915147 0.9973923804914328 0.8818542852354385 0.9275685677536915 1.1173974877927253 0.9612241702808484 1.0 11.469783686465872 -7.573994763595078 7.266296161892157 1.0292796438391907 0.8852464850199959 0.18046731123252135 0.13067142623773814 0.40351334245203935 46.85400673096019 0.06713810243720048 0.038624354100585664 2.6668908197447406e-08 7.573994763595078 -0.14403315881919476 RTIQEVLEEQS(ph)EDEDR ddPTM_A459_Selumetinib_30min_R2 4 RTIQEVLEEQSEDEDR 16 1 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 RTIQEVLEEQS(1)EDEDR;RTIQEVLEEQS(1)EDEDR;RTIQEVLEEQS(1)EDEDR;RTIQEVLEEQS(1)EDEDR 243.99 3.622e-22 35538300.0 110427.0 84576.0 93660.0 116265.0 118463.0 93861.0 98625.0 113892.0 101457.0 92199.0 True False 104289.9094143055 91062.70724529718 87634.01756929753 100429.50643168787 103580.61886734288 106789.50076467522 103211.25792172998 114223.4068641645 121751.23494543428 89536.97530822933 1.1647691811711247 1.017040244343921 0.9787466827823823 1.1216539992105072 1.1568474198594332 1.1926860428002442 1.1527221861853965 1.2757121454120222 1.359787222276696 1.0 16.450195962236705 -6.337941495544142 1.6191383915562942 1.2133453730777561 1.0515900666516627 0.26982199412371166 0.09801792059542168 0.44946027528728727 2.345858717533372 0.036333341521180534 0.0461258532136234 4.5925987625119574e-07 6.337941495544142 -0.16175530642609348 RTIQEVLEEQS(ph)EDEDREAK ddPTM_A459_Selumetinib_30min_R1 1 RTIQEVLEEQSEDEDREAK 19 2 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 RTIQEVLEEQS(1)EDEDREAK 107.07 0.00089934 37878000.0 1169.2 1000.4 1317.1 1605.9 1013.4 1066.0 829.19 771.03 803.1 938.05 True False 1196.4400851328337 883.2727029266572 1138.2450543124285 1325.4597114764777 921.738148930302 1055.2770078505591 766.643530715301 750.5797797415923 1362.8020438967492 1058.4578548807654 1.1303615723723 0.8344901961412128 1.0753806106343753 1.2522555389092842 0.8708312236334959 0.9969948288299447 0.7243023679971301 0.7091258062666508 1.2875354815617746 1.0 10.047748110677402 RTIQEVLEEQS(ph)EDEDREAK ddPTM_A459_Selumetinib_30min_R2 1 RTIQEVLEEQSEDEDREAK 19 2 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 RTIQEVLEEQS(1)EDEDREAK 74.14699999999998 0.0039353 9091700.0 16290.0 16893.0 14971.0 19425.0 15258.0 13019.0 9956.4 11767.0 10816.0 17404.0 True False 15384.667014036753 18188.638780443718 14007.78215919234 16779.28149000594 13341.153631749325 14812.24907528482 10419.392328232323 11801.240021868281 12979.502224290274 16901.501298977422 0.910254464493492 1.0761552159596717 0.8287892247796852 0.9927687010278266 0.7893472535813427 0.8763865891712823 0.6164773261214801 0.698236198850707 0.7679496628548355 1.0 14.044863781109662 -6.45374935500768 1.467461552109598 0.7541186385386625 0.9596661919961417 0.2895148867741061 0.11509998552791922 0.42865387604811533 1.8762016023279147 0.04433366374414992 0.051990894641648605 3.517633956658531e-07 6.45374935500768 0.20554755345747922 RTLEGELHDLR ddPTM_A459_Selumetinib_30min_R1 2 RTLEGELHDLR 11 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 132.17 0.0013918 21713100.0 11697.2 11564.2 15606.8 16874.1 14256.7 12689.0 11425.0 11648.0 6655.9 9067.6 False True 11969.7220012109 10210.258087949278 13487.482282015948 13927.355201086744 12967.184002224827 12561.360180690188 10563.203051679724 11339.057201963702 11294.57617229781 10231.514785903555 1.1698875730211673 0.9979224290440782 1.3182292714465207 1.3612212358110574 1.2673767544264642 1.2277126548257127 1.0324182951123866 1.1082481371757447 1.1039006841742423 1.0 13.320732132876062 -7.2528375763529365 23.771202094176058 1.070162456581112 1.2259908981889813 0.4051781622803231 0.0962340423553503 388.633378993206 1073996.6139857932 0.04131040335233259 0.03143361779372361 5.5867909845073914e-08 7.2528375763529365 0.15582844160786924 RTLEGELHDLR ddPTM_A459_Selumetinib_30min_R2 2 RTLEGELHDLR 11 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 124.6 0.0023794000000000003 4778800.0 19220.5 20276.0 19156.6 19595.3 19985.1 12623.9 10745.599999999999 13700.7 12365.7 20376.5 False True 18152.301555757727 21831.104002384236 17924.085212129037 16926.386336222055 17474.39306893913 14362.727636645504 11245.291692002456 13740.566768727012 14839.185526526104 19788.177500494923 0.9173306412530269 1.1032397501911542 0.9057976770059162 0.8553787399470572 0.8830723834219739 0.7258236710422815 0.5682833445233246 0.6943826316690027 0.7499015776543828 1.0 14.27235112523075 -6.147188518596428 1.1777939442168923 0.7228627988794348 1.0009124310347044 0.39297089037507305 0.116473611477411 0.42239044203439885 1.2006218485073248 0.04618214938834401 0.07650415710880937 7.125436619550116e-07 6.147188518596428 0.27804963215526957 RTLS(ph)MFFPMK ddPTM_A459_Selumetinib_30min_R1 1 RTLSMFFPMK 10 1 G5E9Y3;Q8WWN8 G5E9Y3 ARAP3 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 1 RT(0.003)LS(0.997)MFFPMK 57.149 0.041792 0.0 1251.6 951.17 1220.2 1132.2 1840.5 842.54 1419.7 1938.1 684.75 1029.1 True False 1280.7598448103454 839.8065742130633 1054.5035420788292 934.4825240261949 1674.0270999666673 834.0648125651122 1312.610885992973 1886.695292163964 1161.9707378387486 1161.19500928287 1.1029670594272674 0.7232261312694674 0.908119250986162 0.804759335473989 1.441641659311395 0.7182814306790841 1.1303965961786335 1.6247876343605268 1.0006680433085549 1.0 10.181394561172363 -6.504760470611647 0.9220631019902489 1.2015600350357047 0.8746393674444248 0.13104795379772616 0.2628098852876214 1.0008263460421445 1.8554995329766681 0.14213666284520704 0.17299832030347156 3.127803990484288e-07 6.504760470611647 -0.3269206675912799 RTNS(ph)SSSSPVVLK ddPTM_A459_Selumetinib_30min_R1 1 RTNSSSSSPVVLK 13 1 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 RTNS(0.238)S(0.238)S(0.175)S(0.175)S(0.175)PVVLK 177.21 0.0001856 12852000.0 1372.0 1282.3 1978.0 1841.3 1453.1 1306.4 1447.2 1350.1 772.83 1264.0 True False 1403.9649305527278 1132.1677198749032 1709.3984643762683 1519.7515204817473 1321.6673615656423 1293.2588021162953 1338.0365388525954 1314.290962257142 1311.4360647300766 1426.2467124026298 0.9843773299134436 0.7938091706221525 1.1985292933623286 1.065560051613792 0.9266751327609969 0.906756727899968 0.938152233563128 0.9215032370122773 0.9195015513976925 1.0 10.478007845667971 -6.292575415628564 23.29927832175943 0.9302089142207096 1.008511861975558 0.12720634128915553 0.09577456149462804 646.8824002985051 484063.4392018909 0.031081315998197752 0.03524894948550737 5.098290576117942e-07 6.292575415628564 0.07830294775484836 RTNS(ph)SSSSPVVLK ddPTM_A459_Selumetinib_30min_R2 1 RTNSSSSSPVVLK 13 1 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 RT(0.162)NS(0.594)S(0.09)S(0.12)S(0.025)S(0.008)PVVLK 63.145 0.042765 14570000.0 37619.0 43442.0 40558.0 56930.0 58059.0 39019.0 28128.0 33895.0 30793.0 48814.0 True False 35528.28658078878 46773.86171195383 37948.54243621152 49176.03579027224 50765.10936595451 44393.51307078409 29436.00773457463 33993.62883838069 36952.4604283072 47404.61298599658 0.7494689723821584 0.9866943060113353 0.8005242537771925 1.0373681524369567 1.0708896490928135 0.9364808670392061 0.6209523900821653 0.7170953773722923 0.7795119103540203 1.0 15.532739835470494 -7.220293978888283 20.481571208721995 0.7558147259204504 0.938171199255064 0.24051123854531387 0.1281568718720205 73.96900913686292 36820.15562123042 0.04840960747118306 0.0374957298987104 6.021518446358447e-08 7.220293978888283 0.18235647333461358 RTPALIALR ddPTM_A459_Selumetinib_30min_R1 1 RTPALIALR 9 1 P52895;B4DK69;H0Y804;Q04828;A0A0A0MSS8;P42330;S4R3Z2;P42330-2 P52895;Q04828;A0A0A0MSS8;P42330-2 AKR1C2;AKR1C1;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 128.28 0.0052036 0.0 2226.6 2726.6 2537.9 3074.4 2700.5 2765.5 2411.4 2426.4 1749.0 2088.5 False True 2278.475447790598 2407.36840443805 2193.2671196868214 2537.5137536355196 2456.2402518119993 2737.681580873097 2229.506156570723 2362.0439899420276 2967.9252580941547 2356.5793187127333 0.9668571007553444 1.0215520374476765 0.9306994686199995 1.0767784192477852 1.042290506543911 1.1617184107210694 0.9460772819599286 1.0023188997653936 1.2594209049222096 1.0 11.202478525653662 -5.77715304859481 24.918813988086477 1.067425781511952 0.9778877843024174 0.20847352837135702 0.08616151712112809 376.3800592315891 596864.3009088413 0.023971470173215256 0.035693167883849825 1.6705018133455804e-06 5.77715304859481 -0.0895379972095347 RTPALIALR ddPTM_A459_Selumetinib_30min_R2 1 RTPALIALR 9 1 P52895;B4DK69;H0Y804;Q04828;A0A0A0MSS8;P42330;S4R3Z2;P42330-2 P52895;Q04828;A0A0A0MSS8;P42330-2 AKR1C2;AKR1C1;AKR1C3 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1;Aldo-keto reductase family 1 member C3 0 107.79 0.016759 2639900.0 12641.0 10916.0 10588.0 10539.0 13195.0 9311.8 8816.8 9184.6 7061.0 11021.0 False True 11938.463825932393 11753.222099527839 9906.779607342767 9103.570019210949 11537.326135203322 10594.41592589577 9226.798670157763 9211.325665407614 8473.397300824121 10702.795094003115 1.1154529000206344 1.0981451103472295 0.9256254576800818 0.8505787450151009 1.0779731868049873 0.9898737510009818 0.8620924337164627 0.8606467361566899 0.791699479098862 1.0 13.385699993153498 -1.5228787452827994 0.42903524830363665 0.8930381451408353 5.786996971353176 0.40972677972767735 0.08434385564770434 82.90645713309588 1.0439973216276586 0.05944402704131248 350.48026913018504 0.02999999999982994 1.5228787452827994 4.893958826212341 RTPAPPEPGS(ph)PAPGEGPSGR ddPTM_A459_Selumetinib_30min_R1 2 RTPAPPEPGSPAPGEGPSGR 20 1 P0C1Z6-2;P0C1Z6 P0C1Z6-2 TFPT TCF3 fusion partner 1 RTPAPPEPGS(1)PAPGEGPSGR;RTPAPPEPGS(1)PAPGEGPSGR 143.47 2.1126e-05 119297000.0 5794.3 6048.700000000001 8098.1 8856.7 6761.4 6542.299999999999 6040.4 4918.4 3504.3 4533.6 True False 5929.295916254859 5340.515392035657 6998.422499679207 7310.043605849497 6149.832563822129 6476.49040193312 5584.767764846058 4787.948054785219 5946.541156054516 5115.531721003611 1.1590771477205495 1.0439805055080191 1.3680733267559904 1.4289899866783247 1.202188335295006 1.2660444221940048 1.0917277165765258 0.9359629293523131 1.1624483006603017 1.0 12.320668489713032 -7.3713331957659625 4.045549285744355 1.0333701436148954 1.2476510256178992 0.4283903491113603 0.11271323173354288 0.24682210293594042 7.006385530478519 0.05363859442883202 0.034974471331704844 4.252720143171376e-08 7.3713331957659625 0.21428088200300377 RTPAPPEPGS(ph)PAPGEGPSGR ddPTM_A459_Selumetinib_30min_R2 3 RTPAPPEPGSPAPGEGPSGR 20 1 P0C1Z6-2;P0C1Z6 P0C1Z6-2 TFPT TCF3 fusion partner 1 RTPAPPEPGS(0.994)PAPGEGPS(0.005)GR;RTPAPPEPGS(1)PAPGEGPSGR;RTPAPPEPGS(1)PAPGEGPSGR 143.63 2.041e-05 75638200.0 69038.0 101053.0 89643.0 97186.0 89081.0 68995.0 56673.0 64381.0 57195.0 87062.0 True False 65201.14434101101 108803.44016339198 83875.46697591885 83949.09914479889 77889.84838575567 78498.43497574887 59308.406795419054 64568.338051151695 68635.59816182351 84548.29384575805 0.7711704326045637 1.2868791931139703 0.9920420999734586 0.9929129888528293 0.9212468382608712 0.9284449325370661 0.7014737269993376 0.7636858783802793 0.8117916404917151 1.0 16.367488021410026 -6.626864680213318 1.4492664907196873 0.8051361948909271 1.0345334978423761 0.2480242018023061 0.13916169467005182 0.46396156580327963 2.0220278066542963 0.057692855233347974 0.058562310531169295 2.361213838150621e-07 6.626864680213318 0.229397302951449 RTPHVQAVQGPLGS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 RTPHVQAVQGPLGSPPK 17 1 Q15149 Q15149 PLEC Plectin 1 RTPHVQAVQGPLGS(1)PPK;RTPHVQAVQGPLGS(1)PPK 142.84 0.0008939999999999998 212001000.0 9121.4 9802.2 11238.7 12313.4 9142.3 8815.6 8591.8 8799.6 5116.9 7132.0 True False 9333.910872845228 8654.553867080847 9712.54626976015 10163.095841144806 8315.38057920416 8726.923067924381 7943.713608702132 8566.206022870863 8683.005576410504 8047.461671562939 1.1598577605940237 1.0754389670053566 1.2069080495382871 1.2628945940877006 1.0332923496346629 1.0844317654549922 0.9871079767639753 1.0644606178294698 1.0789744556464762 1.0 12.974318085115863 -6.287638664629667 24.90092774268093 1.0440400783670414 1.1712603715050942 0.6124563164529051 0.05248290968907109 533.4779578063309 507038.7871384723 0.01707881263630026 0.019372005229366076 5.156574959941158e-07 6.287638664629667 0.12722029313805283 RTPHVQAVQGPLGS(ph)PPKR ddPTM_A459_Selumetinib_30min_R1 2 RTPHVQAVQGPLGSPPKR 18 2 Q15149 Q15149 PLEC Plectin 1 RTPHVQAVQGPLGS(1)PPKR;RTPHVQAVQGPLGS(1)PPKR 127.9 0.00079731 91764000.0 4732.9 5437.4 6921.6 6784.8 5876.4 5331.8 4846.4 5845.1 3171.77 4686.9 True False 4843.167361379739 4800.7866802213175 5981.6847376272935 5599.9620464696445 5344.880657562687 5278.166932887061 4480.832146140977 5690.068960439394 5382.2620330847885 5288.50926927206 0.915790653808645 0.9077769246081183 1.1310719964854379 1.0588923572484263 1.0106592208541947 0.9980443758612486 0.8472769769311086 1.0759306017483083 1.0177276353390288 1.0 12.368645395864036 RTPHVQAVQGPLGS(ph)PPKR ddPTM_A459_Selumetinib_30min_R2 1 RTPHVQAVQGPLGSPPKR 18 2 Q15149 Q15149 PLEC Plectin 1 RTPHVQAVQGPLGS(1)PPKR 52.365 0.032188999999999995 112590000.0 35769.0 40937.0 35210.0 44507.0 39437.0 29438.0 40952.0 35459.0 25811.0 38868.0 True False 33781.10217465197 44076.73626679837 32944.6269337494 38445.06982114257 34482.57148874677 33492.81728844261 42856.34914484855 35562.179819446545 30973.921219596585 37745.779848808 0.8949636836214093 1.1677262052433206 0.8728029216964179 1.0185263087724137 0.9135477297559589 0.8873261440775425 1.1353944551287882 0.9421498234211099 0.8205929601577626 1.0 15.204027733085475 -5.292914110606379 24.999438960297454 0.9524273508736208 1.0313452200262272 0.09175614210253835 0.10338505035920031 1461.8632017130326 1161110.9903475079 0.02629002495344744 0.054734034761341 5.094316101813594e-06 5.292914110606379 0.07891786915260635 RTPS(ph)DDEEDNLFAPPK ddPTM_A459_Selumetinib_30min_R1 5 RTPSDDEEDNLFAPPK 16 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 RT(0.233)PS(0.767)DDEEDNLFAPPK;RT(0.001)PS(0.999)DDEEDNLFAPPK;RT(0.239)PS(0.761)DDEEDNLFAPPK;RT(0.015)PS(0.985)DDEEDNLFAPPK;RT(0.235)PS(0.765)DDEEDNLFAPPK 205.12 2.9275e-07 276465000.0 25261.3 29356.699999999997 28221.0 29571.9 28357.4 24755.899999999998 27402.999999999996 25547.199999999997 15084.919999999998 21905.0 True False 25849.839140066757 25919.603916440432 24388.743206856765 24407.72279831323 25792.478176905617 24506.87812255875 25335.96964771813 24869.605266999217 25598.007481034685 24716.72012276869 1.045844230612712 1.0486668048065027 0.9867305648045998 0.9874984495143101 1.0435234953826238 0.9915101194993654 1.0250538713014352 1.0061854948177242 1.0356555139148163 1.0 14.593199691701182 -5.236956646116723 24.048818145371936 1.0100801415557026 1.0472555405233006 0.3928400990698836 0.018755033640653694 488.93699828416555 480267.78212149953 0.004674616404094375 0.012353738466978481 5.794865413662012e-06 5.236956646116723 0.03717539896759803 RTPS(ph)DDEEDNLFAPPK ddPTM_A459_Selumetinib_30min_R2 4 RTPSDDEEDNLFAPPK 16 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 RT(0.013)PS(0.987)DDEEDNLFAPPK;RT(0.002)PS(0.998)DDEEDNLFAPPK;RT(0.006)PS(0.994)DDEEDNLFAPPK;RT(0.311)PS(0.689)DDEEDNLFAPPK 202.84 7.7201e-07 59235900.0 216066.0 204861.0 227608.0 233609.0 229311.0 175037.0 179383.0 177912.0 156978.0 188049.0 True False 204057.9167007285 220573.17996806258 212963.94908085323 201791.05120199695 200502.90211364973 199146.75792231548 187724.66494067127 178429.69446508307 188377.98633179025 182619.5367600207 1.1173936826314472 1.2078290410840136 1.1661619170609765 1.1049806323141067 1.0979269013102877 1.090500838275661 1.027954994691281 0.9770569876078292 1.0315324946823006 1.0 17.47848158849436 -6.772110278949594 0.7908828304611712 0.9958945712584772 1.1687711703419954 0.827727084044825 0.02882414293506953 0.2474147572432242 0.3381727392524601 0.019961447232767222 0.019028304833417314 1.6900117381085745e-07 6.772110278949594 0.17287659908351816 RTQS(ph)LSALPK ddPTM_A459_Selumetinib_30min_R1 1 RTQSLSALPK 10 1 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 RTQS(0.858)LS(0.142)ALPK 109.16 0.018388 28531000.0 2406.6 3311.1 3369.9 3520.9 3265.6 3530.4 3869.7 4211.7 2649.3 2309.7 True False 2462.669097571568 2923.4348727113697 2912.286089535687 2906.040910478565 2970.227056588508 3494.887381346727 3577.805413486657 4099.992034470341 4495.668602783789 2606.172493383194 0.9449371075107398 1.1217349888135466 1.1174571510249933 1.11506084798942 1.139689358294438 1.3410038630289782 1.3728198814814982 1.5731852150538013 1.7250080776302539 1.0 11.347716858634485 -6.882362279111847 1.5015131527944172 1.4755462805624528 1.0755433126526153 0.43007253621581976 0.18073831048166586 0.33924839069684193 1.5785377878251925 0.08295984546736539 0.06795719172900641 1.311105746521461e-07 6.882362279111847 -0.4000029679098376 RTQS(ph)LSALPK ddPTM_A459_Selumetinib_30min_R2 3 RTQSLSALPK 10 1 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 RT(0.233)QS(0.767)LSALPK;RT(0.008)QS(0.973)LS(0.019)ALPK;RT(0.008)QS(0.901)LS(0.091)ALPK 108.32 0.007466800000000002 36691900.0 125550.0 122754.0 137997.0 141700.0 133900.0 101385.0 109564.0 127992.0 112556.0 163179.0 True False 118572.43361647114 132168.83708367878 129118.42325977342 122400.21555386588 117078.28491881197 115349.86346860373 114658.94309694727 128364.4355297838 135070.3450774055 158467.59828004093 0.7482440252986746 0.8340432903520916 0.8147938421556551 0.7723990070043376 0.7388152921451706 0.7279081952435452 0.723548184874514 0.8100358491137135 0.8523530774960807 1.0 17.27382835846452 -8.616650276153553 1.656535275390601 0.9988948494237644 0.7687713207942277 0.8016740746644161 0.03517790074512698 0.23393319964804601 1.3797165067306074 0.03810905619767177 0.01094789657562082 2.4174067133442526e-09 8.616650276153553 -0.23012352862953667 RTQS(ph)SLTVSEVLTR ddPTM_A459_Selumetinib_30min_R1 3 RTQSSLTVSEVLTR 14 1 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 RT(0.013)QS(0.817)S(0.161)LT(0.005)VS(0.003)EVLTR;RT(0.025)QS(0.884)S(0.082)LT(0.008)VS(0.001)EVLTR;RT(0.001)QS(0.935)S(0.046)LT(0.015)VS(0.003)EVLTR 145.94 0.00091122 22882400.0 5363.5 6125.199999999999 9929.9 10148.6 7437.9 7142.1 6098.9 5745.2 4244.6 4623.7 True False 5488.459114445738 5408.058736471771 8581.474121036357 8376.337522815978 6765.143258267901 7070.256958507949 5638.855062747437 5592.818632960321 7202.776186681787 5217.19693365193 1.051993854984487 1.0365832084253417 1.6448438175074798 1.6055245046984867 1.2967007656221328 1.355183070223672 1.0808208190064152 1.0719968412320338 1.3805835352356526 1.0 12.349059176498264 -7.252863758129159 23.647201294570717 1.13935003394871 1.3434609250365217 0.17989517331237548 0.20652700677362304 581.1696108264374 1602574.1973944744 0.0868645747984209 0.06611769588300284 5.586454190676295e-08 7.252863758129159 0.20411089108781177 RTS(ph)FLEGTLR ddPTM_A459_Selumetinib_30min_R2 1 RTSFLEGTLR 10 1 E9PEW5;A0A0A0MQX1;Q9HD67-3;Q9HD67 E9PEW5 MYO10 Unconventional myosin-X 1 RT(0.352)S(0.648)FLEGTLR 70.68 0.037641 3131500.0 11595.0 8228.0 10045.0 12292.0 11653.0 8310.1 9104.2 9276.7 9966.6 9456.3 True False 10950.596318462629 8859.061142810095 9398.715636169065 10617.808395117272 10189.04596085822 9454.740843423018 9527.563339630058 9303.693661159637 11960.19849007133 9183.272048581945 1.1924503881112385 0.9646954915354039 1.0234604383325863 1.1562118969084494 1.109522391033987 1.0295612275673565 1.0374911348838107 1.0131131487710079 1.3023896522719471 1.0 13.164792569802374 RTS(ph)FSFQK ddPTM_A459_Selumetinib_30min_R1 2 RTSFSFQK 8 1 H0Y7F8;Q9BPZ7-4;Q9BPZ7-3;Q9BPZ7-2;Q9BPZ7 H0Y7F8 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 1 RT(0.444)S(0.555)FS(0.001)FQK;RT(0.437)S(0.559)FS(0.004)FQK 105.4 0.007275 90484000.0 5968.1 7297.9 8016.099999999999 9172.4 7751.1 6836.9 6857.700000000001 6669.7 4070.2999999999997 5464.6 True False 6107.145118098929 6443.458475298332 6927.557649285447 7570.612527272454 7050.014373567857 6768.126993408521 6340.4181678340565 6492.797889761102 6907.001817050104 6166.0346397115645 0.9904493689942374 1.0449922603094142 1.1235028756843808 1.2277927338446792 1.143362758321715 1.0976466057811705 1.0282813085413756 1.0529940665504958 1.1201691558082458 1.0 12.590127278940084 -7.092216748600301 6.106701378565554 1.0551855605869713 1.1113167090673042 0.14147073138837163 0.06462029058305188 0.5407207730661842 29.333088527098617 0.02745967961344227 0.0212843272041096 8.086921946504011e-08 7.092216748600301 0.05613114848033285 RTS(ph)FSTSDVSK ddPTM_A459_Selumetinib_30min_R1 2 RTSFSTSDVSK 11 1 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 RT(0.13)S(0.861)FS(0.001)T(0.002)S(0.007)DVSK;RT(0.209)S(0.784)FS(0.001)T(0.001)S(0.004)DVSK 102.33 0.025835000000000004 40610000.0 13528.900000000001 16717.0 15936.7 18166.2 15018.400000000001 14833.900000000001 14900.5 13734.6 7333.9 12010.599999999999 True False 13844.097047343148 14759.765868477543 13772.58367402695 14993.814191807685 13659.988371713871 14684.684434103567 13776.543288538629 13370.313791731682 12445.092653137059 13552.27750315114 1.0215328784497038 1.0890985566850768 1.0162560256624458 1.1063685929041347 1.007947805712928 1.08355842261119 1.0165481990267204 0.986573200602102 0.9183026727606013 1.0 13.726247700973362 -7.700317202677693 2.4442134483458204 0.9589571273403312 1.0541549237388472 0.5278178098205648 0.03642164313648062 0.20474650917876422 2.451152659353088 0.02068564751236382 0.009548691854217445 1.9938055350649135e-08 7.700317202677693 0.095197796398516 RTS(ph)FSTSDVSK ddPTM_A459_Selumetinib_30min_R2 1 RTSFSTSDVSK 11 1 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 RT(0.197)S(0.673)FS(0.107)T(0.018)S(0.006)DVSK 95.822 0.0107 24246000.0 114760.0 103390.0 117390.0 137570.0 120740.0 104920.0 95996.0 119930.0 65142.0 100600.0 True False 108382.0986206789 111319.68054875232 109837.25520456789 118832.72867851316 105571.56177070466 119371.7776310686 100460.00421246544 120278.9764445196 78172.22021955602 97695.41660980954 1.109387752073891 1.1394565314497545 1.124282581681925 1.216359301205756 1.0806193927433876 1.2218769495383117 1.0282980276720404 1.2311629410917775 0.8001626169605462 1.0 16.57600325914938 -8.25986972761238 24.999996204673486 0.9000813024082727 1.14217410841986 0.6215991550071045 0.07609316419992916 78.27047787284538 1246679.5158483544 0.052122730062375215 0.017289832802629124 5.497057406541758e-09 8.25986972761238 0.24209280601158734 RTS(ph)FYLPK ddPTM_A459_Selumetinib_30min_R2 1 RTSFYLPK 8 1 Q9NS23-3;Q9NS23-4;Q9NS23-2;Q9NS23-5;Q9NS23 Q9NS23-3 RASSF1 Ras association domain-containing protein 1 1 RT(0.07)S(0.93)FYLPK 80.102 0.024107 6541100.0 25591.0 28822.0 27254.0 29390.0 32188.0 24805.0 29625.0 31930.0 23838.0 30566.0 True False 24168.7546688898 31032.554722663157 25500.50731191157 25387.031299422106 28144.255675628978 28221.663592629207 31002.621200823825 32022.911013703924 28606.266089370525 29683.480159994495 0.8142156694100481 1.0454486655674176 0.8590807807731228 0.8552579132428391 0.9481454170444614 0.9507531947235948 1.044440241970252 1.0788125530126473 0.9637099806081441 1.0 14.85737262633392 -6.957549288156702 2.147789273449411 1.0275127551076013 0.9046374854889381 0.41973953638001016 0.06492108072911786 0.3108274982058824 2.899622880816151 0.02718390682860921 0.02192837034227789 1.1026830830520564e-07 6.957549288156702 -0.12287526961866324 RTS(ph)LPCIPR ddPTM_A459_Selumetinib_30min_R2 1 RTSLPCIPR 9 1 Q14432 Q14432 PDE3A cGMP-inhibited 3,5-cyclic phosphodiesterase A 1 RT(0.181)S(0.819)LPCIPR 99.5 0.009627 1935700.0 8624.8 5812.3 7393.8 6311.7 6930.5 3485.7 5288.7 4835.4 5289.1 4353.6 True False 8145.4681438099615 6258.084720509862 6918.09095776076 5452.035571710196 6059.8286305438905 3965.823534965841 5534.635029360239 4849.470213456438 6347.067789801563 4227.9002559887485 1.9265989381542399 1.4801874078380612 1.6362947418074498 1.2895374161174877 1.4332950787947862 0.9380125582074269 1.309074172580236 1.147016230240353 1.5012340418417038 1.0 12.04572562593145 -1.5228787454004145 0.4007985428202205 1.1775102399471067 12.905666384786786 0.6031645039047562 0.17788176130487246 49.427459409010154 0.6548078815627157 0.12306389122464184 458.0325875044101 0.02999999999170538 1.5228787454004145 11.728156144839678 RTS(ph)MGGTQQQFVEGVR ddPTM_A459_Selumetinib_30min_R1 1 RTSMGGTQQQFVEGVR 16 1 A0A2R8Y6G0;A0A2R8Y804;A0A2R8Y543;A0A2R8Y5C3;A0A2R8Y750;A0A2R8Y5Z1;B4DGU4;A0A2R8YCH5;A0A2R8Y5A3;P35222 A0A2R8Y6G0 CTNNB1 Catenin beta-1 1 RT(0.04)S(0.96)MGGTQQQFVEGVR 158.5 3.5141e-05 30462000.0 925.0 1043.8 1352.7 1026.4 1252.2 1009.2 1087.3 969.48 406.76 772.87 True False 946.5507002633182 921.5914107505446 1169.010769849231 847.158507914226 1138.9387310938657 999.048364280285 1005.2840856097474 943.7662410851449 690.2420114250305 872.0753928913139 1.0854000789141474 1.056779515008517 1.3404927823653476 0.9714280609449633 1.3060094808062206 1.145598617303029 1.1527490556484894 1.0822071678414686 0.791493507386528 1.0 9.76830905441984 -8.080967216859822 4.871340288418208 0.898998069190106 1.151840537711183 0.4424892662183123 0.11293755499642442 0.19230095317200077 7.908729236261063 0.0752826663606462 0.027448133428949216 8.299134119688194e-09 8.080967216859822 0.25284246852107706 RTS(ph)MGGTQQQFVEGVR ddPTM_A459_Selumetinib_30min_R2 3 RTSMGGTQQQFVEGVR 16 1 A0A2R8Y6G0;A0A2R8Y804;A0A2R8Y543;A0A2R8Y5C3;A0A2R8Y750;A0A2R8Y5Z1;B4DGU4;A0A2R8YCH5;A0A2R8Y5A3;P35222 A0A2R8Y6G0 CTNNB1 Catenin beta-1 1 RT(0.085)S(0.915)MGGTQQQFVEGVR;RT(0.383)S(0.616)MGGT(0.001)QQQFVEGVR;RT(0.085)S(0.914)MGGTQQQFVEGVR 126.91 0.00055525 42726000.0 65964.0 47758.0 56091.0 71314.0 54112.0 36378.1 56767.0 46294.4 46016.0 50276.0 True False 62297.984954814056 51420.88503382651 52482.16612726321 61600.910176488214 47313.966792582214 41388.85306748739 59406.777981676525 46429.109039549534 55220.485794465734 48824.40124726439 1.2759600397210111 1.053180043589528 1.074916738076819 1.2616828594480651 0.9690639431084308 0.8477083591436032 1.2167436049203997 0.9509406742013234 1.1310018020458514 1.0 15.575314731436242 -1.5228787452910872 0.6747947221041677 1.0404359627064892 22.378467255190042 0.22168644318536257 0.11926023892591261 418.336098750164 2.4546472406779962 0.04868300071696904 13405.15665347033 0.029999999999257437 1.5228787452910872 21.338031292483553 RTS(ph)PGGFK ddPTM_A459_Selumetinib_30min_R2 1 RTSPGGFK 8 1 Q5MIZ7-5;Q5MIZ7-3;Q5MIZ7-2;Q5MIZ7 Q5MIZ7-5 SMEK2 Serine/threonine-protein phosphatase 4 regulatory subunit 3B 1 RT(0.246)S(0.754)PGGFK 67.334 0.040936 5697100.0 36538.0 34179.0 34716.0 42976.0 42524.0 27588.0 34385.0 34437.0 27524.0 36319.0 True False 34507.364233202905 36800.41939719328 32482.41035592288 37122.594662264906 37181.75495061662 31387.996581070536 35983.97063258491 34537.20596864775 33029.56908481561 35270.37610190538 0.978366778213594 1.0433804077072273 0.9209544650749588 1.0525148514154763 1.054192187891299 0.8899252021124575 1.0202321213875851 0.9792128631931991 0.9364677311459484 1.0 15.10616933942081 -6.72573852048718 24.9999959931993 0.9673095608165543 1.0091708267515402 0.16726517674868024 0.049757089823864564 354.0244679011454 247909.25461548995 0.016156644902303105 0.016156133328520745 1.8804486543639384e-07 6.72573852048718 0.04186126593498596 RTS(ph)PQVLGSILK ddPTM_A459_Selumetinib_30min_R1 1 RTSPQVLGSILK 12 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 RT(0.006)S(0.994)PQVLGSILK 193.06 0.0002751 131580000.0 4641.0 4833.2 5762.6 5679.6 4838.9 4549.0 4710.3 4645.6 2635.6 3867.0 True False 4749.12627018601 4267.326697106277 4980.070571695999 4687.764479296219 4401.222349377183 4503.241190161532 4354.998278715711 4522.383596964507 4472.420703392196 4363.367117769758 1.0884085940981798 0.9779893788280253 1.1413365956338453 1.0743456493049501 1.0086756925524922 1.0320564528760687 0.9980820227067384 1.0364435251269957 1.0249929888269815 1.0 12.091226146573677 -6.2584514520004975 24.845495464980704 1.0183667016019335 1.0689690470435058 0.3112328311984708 0.03914329384781414 328.4030345363096 2730777.274795137 0.01167642088394494 0.01441001613292144 5.515038492901702e-07 6.2584514520004975 0.05060234544157227 RTS(ph)PQVLGSILK ddPTM_A459_Selumetinib_30min_R2 1 RTSPQVLGSILK 12 1 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 RT(0.231)S(0.769)PQVLGSILK 165.24 0.00026578 163100000.0 164860.0 146360.0 179920.0 205170.0 173400.0 145390.0 133410.0 133870.0 119510.0 151940.0 True False 155697.74118686936 157585.34137842536 168344.14308208408 177225.4920620087 151615.9417843316 165416.1527809862 139613.82934690002 134259.5395366284 143415.33938839976 147553.09741247018 1.055198053563265 1.0679907378556144 1.1409055183131438 1.2010963861137545 1.027534795562469 1.1210618799724794 0.9461938230725397 0.9099066159303932 0.9719574980354109 1.0 17.170874680362324 -7.264642914469208 24.993511545204857 0.9495066931756031 1.103585891020815 0.6664871458948285 0.050230850932452185 171.1110307828139 1334972.8831180977 0.0210962554248156 0.014898578268959786 5.436971863635672e-08 7.264642914469208 0.15407919784521185 RTS(ph)PSSLPGR ddPTM_A459_Selumetinib_30min_R1 2 RTSPSSLPGR 10 1 H0Y4R5;Q5SNT2 H0Y4R5 TMEM201 Transmembrane protein 201 1 RT(0.207)S(0.792)PS(0.001)SLPGR;RT(0.164)S(0.832)PS(0.003)S(0.001)LPGR 76.07300000000002 0.029974 5314400.0 752.74 903.22 949.8699999999999 1268.23 1249.62 977.02 953.99 952.08 688.04 1036.82 True False 770.2773774229296 797.470582504414 820.8828712624301 1046.7574381255447 1136.5920916383293 967.1920658631832 882.0297662382443 926.8277456083102 1167.5536275466557 1169.905946482037 0.6584096608271719 0.681653584976165 0.7016656969142383 0.8947364027622855 0.9715243307003575 0.8267263439181379 0.7539322018924255 0.7922241513476579 0.997989309360761 1.0 10.192176834985164 -3.582325288010167 0.3930782064234004 0.903316032751425 3.640540345607694e-22 0.5181830140346152 0.08681884164096337 13.82427029547578 0.8075149169398773 0.07389398235794116 7.124937555020655 0.0002616222714670077 3.582325288010167 -0.903316032751425 RTS(ph)PSSLPGR ddPTM_A459_Selumetinib_30min_R2 1 RTSPSSLPGR 10 1 H0Y4R5;Q5SNT2 H0Y4R5 TMEM201 Transmembrane protein 201 1 RT(0.455)S(0.544)PS(0.001)SLPGR 71.176 0.036893 4938600.0 10139.0 5117.3 10224.0 10104.0 5402.9 4729.4 12624.0 6082.2 9232.4 7052.1 True False 9575.514969632819 5509.780455287079 9566.198971049533 8727.817769627807 4724.13939946116 5380.83192078132 13211.041013981438 6099.898195037588 11079.137974809322 6848.487549443732 1.398194112276745 0.804525147415156 1.3968338121351402 1.274415366402575 0.6898076933563058 0.7856963865282018 1.9290450509842139 0.8906927479970453 1.6177495972390612 1.0 12.741569696700035 RTS(ph)QEGPGDSVK ddPTM_A459_Selumetinib_30min_R1 1 RTSQEGPGDSVK 12 1 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 RT(0.026)S(0.973)QEGPGDS(0.001)VK 143.05 0.0015398 2876500.0 1042.3 1378.5 919.96 1246.3 1067.6 1209.8 1155.6 1421.4 590.25 1039.3 True False 1066.5835620372509 1217.1045791527367 795.0344849785607 1028.6571009484612 971.0357685000886 1197.6305104105118 1068.4321616211023 1383.6998546421019 1001.6111398456688 1172.7042786392826 0.9095076921479589 1.0378614637314814 0.6779496753444599 0.8771666648492467 0.8280312319034131 1.021255343077755 0.911084048282684 1.1799222360198451 0.8541037651946343 1.0 10.195623538839648 -6.765596602511934 24.991802951005024 0.9993814192643034 0.8658071055817852 0.2359231988172673 0.1141642635431032 155.39116164992964 934151.7956668547 0.03888116144508265 0.03551498428087952 1.715550068433257e-07 6.765596602511934 -0.13357431368251815 RTS(ph)QEGPGDSVK ddPTM_A459_Selumetinib_30min_R2 1 RTSQEGPGDSVK 12 1 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 RT(0.035)S(0.965)QEGPGDSVK 138.31 0.0022481 2654800.0 21029.0 14802.0 19324.0 22644.0 20168.0 14601.0 17720.0 17337.0 11717.0 18060.0 True False 19860.29236575685 15937.265804068424 18080.71487838038 19559.848136921224 17634.315535792386 16612.15521531866 18544.015111513883 17387.44779970515 14060.7274003337 17538.56087448475 1.1323786773548665 0.9086986052119075 1.0309121146127993 1.1152481823851956 1.0054596646779008 0.9471789238697554 1.0573282063576765 0.9913839524313858 0.8017036004812327 1.0 14.098242751937354 -8.020217585158763 22.844015050006444 0.899415672377611 1.0231365398065215 0.29325211280270846 0.0777758684329658 306.56515550337156 346385.2001206724 0.048653668325710824 0.018990436019796816 9.545142466043378e-09 8.020217585158763 0.12372086742891053 RTS(ph)SEDNLYLAVLR ddPTM_A459_Selumetinib_30min_R1 2 RTSSEDNLYLAVLR 14 1 Q15149-4 Q15149-4 PLEC Plectin 1 RT(0.107)S(0.446)S(0.446)EDNLYLAVLR;RT(0.025)S(0.665)S(0.311)EDNLYLAVLR 176.28 3.5479000000000004e-05 31646000.0 2002.4 1894.02 2649.8 3523.3 2664.3 2178.2 2300.93 2086.3999999999996 1400.0700000000002 1643.66 True False 2049.0520240078586 1672.2672578939912 2289.971714309523 2908.021795532143 2423.314535420371 2156.289285647362 2127.3689976106293 2031.0618944176742 2375.8165329330377 1854.6397716041984 1.104824805000003 0.9016668808129455 1.234725874733495 1.567971225493998 1.3066227590516346 1.1626458780091011 1.1470523980894305 1.0951247382454636 1.2810123935162028 1.0 10.856923282727669 -10.78278561350711 9.753009321730513 0.9999999878600203 1.2006103121556733 0.11868542759105405 0.16364597125781602 4.797266945925747e-08 3.6162196148692345e-09 0.17532325656280753 0.042522133079352285 1.6489761964361667e-11 10.78278561350711 0.20061032429565295 RTS(ph)SEDNLYLAVLR ddPTM_A459_Selumetinib_30min_R2 2 RTSSEDNLYLAVLR 14 1 Q15149-4 Q15149-4 PLEC Plectin 1 RT(0.436)S(0.483)S(0.081)EDNLYLAVLR;RT(0.106)S(0.788)S(0.106)EDNLYLAVLR 159.64 0.00015233 13150300.0 20074.4 28605.0 27631.0 26052.0 23002.2 14344.0 14303.400000000001 13492.3 9494.400000000001 24738.0 True False 18958.74521219026 30798.91152042815 25853.25154235814 22503.6726577933 20112.457993722925 16319.755798132377 14968.536441649414 13531.560359229492 11393.545295700966 24023.749662957016 0.7891667819625741 1.2820193330568197 1.0761538854287218 0.9367260720541236 0.8371906249395765 0.6793175930939843 0.6230724450450745 0.5632576325124731 0.4742617391351291 1.0 14.552173726178355 -6.42277068544924 1.4913520509972946 0.6289913840348382 1.0671807139726344 0.4828783843245832 0.17168515783854482 0.29718923693880706 1.336503899752102 0.06506132482050132 0.07811492080320093 3.777716078269348e-07 6.42277068544924 0.43818932993779613 RTS(ph)SEELR ddPTM_A459_Selumetinib_30min_R2 1 RTSSEELR 8 1 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 RT(0.408)S(0.535)S(0.057)EELR 79.693 0.024614 5686900.0 9148.5 8618.6 7675.9 8824.7 9834.1 7143.6 13235.0 17684.0 14780.0 16275.0 True False 8640.062994347169 9279.618906833139 7182.0409508880175 7622.760636543399 8598.652440030539 8127.566056855714 13850.453724654975 17735.4575122562 17736.412987704352 15805.098462471711 0.5466630286968789 0.5871281934033536 0.45441292048520654 0.48229757344715074 0.5440429530032692 0.5142369771472255 0.8763282150719955 1.1221352118981107 1.1221956655201126 1.0 13.948102402509493 -7.429449359108132 2.689185686215887 1.0903237427697516 0.5179014889616949 0.9632257445986561 0.049789339890080365 0.048689994609559674 0.6860079823282477 0.02590575124936698 0.015391074429372235 3.720065964483274e-08 7.429449359108132 -0.5724222538080568 RTS(ph)STLDSEGTFNSYR ddPTM_A459_Selumetinib_30min_R1 1 RTSSTLDSEGTFNSYR 16 1 Q92609;Q92609-2;C9JNM0;C9JED7;F2Z3C3;C9K0P2;C9J397;C9JWX0;C9JW04;C9JDR8 Q92609 TBC1D5 TBC1 domain family member 5 1 RT(0.012)S(0.985)S(0.003)TLDSEGTFNSYR 216.77 2.4318e-10 11399000.0 2961.8 2779.8 3624.5 4375.4 3316.1 3093.3 2971.4 3384.7 2011.9 2302.5 True False 3030.804177340428 2454.3397237060417 3132.312807953382 3611.3185264301496 3016.1593405050057 3062.1842104916805 2747.2649057121344 3294.926760944929 3414.0473566378682 2598.048303249254 1.166569602863021 0.9446859477695304 1.205640712698047 1.3900120801886737 1.160932741986683 1.1786479129975969 1.0574341140140706 1.268231524727282 1.3140815559002823 1.0 11.343212538469567 -5.298833070876474 22.119128888257098 1.206435842735064 1.0556278870400784 0.18072763458913899 0.1189047225179331 193.78780843538303 114629.01645266144 0.03080714314320406 0.06413679649765502 5.0253571130833285e-06 5.298833070876474 -0.15080795569498573 RTSS(ph)EDNLYLAVLR ddPTM_A459_Selumetinib_30min_R1 4 RTSSEDNLYLAVLR 14 1 Q15149-4 Q15149-4 PLEC Plectin 1 RT(0.011)S(0.385)S(0.604)EDNLYLAVLR;RT(0.001)S(0.006)S(0.993)EDNLYLAVLR;RT(0.006)S(0.056)S(0.938)EDNLYLAVLR;RTS(0.001)S(0.999)EDNLYLAVLR 240.66 7.4323e-20 124633200.0 5806.15 6225.68 9593.89 10294.9 8265.88 6530.44 6077.99 5543.23 4164.18 4336.1900000000005 True False 5941.421998198772 5496.774491359889 8291.092433465546 8497.088974207098 7518.232613459644 6464.749702765106 5619.52232088218 5396.20553345134 7066.309320326195 4892.782224567373 1.2143238193529287 1.1234455651346553 1.6945557870601233 1.7366579144973946 1.5365966168920213 1.3212829441508054 1.148533096908695 1.1028910108355539 1.4442313178880566 1.0 12.256439355185206 -6.999849245359752 4.007600887423137 1.1855656400690515 1.4695585266966054 0.30130331996894133 0.20534143576144756 0.3135286754122673 11.582202533213582 0.08612885685330078 0.07084344230349167 1.0003471856423231e-07 6.999849245359752 0.28399288662755384 RTSS(ph)EDNLYLAVLR ddPTM_A459_Selumetinib_30min_R2 2 RTSSEDNLYLAVLR 14 1 Q15149-4 Q15149-4 PLEC Plectin 1 RT(0.111)S(0.2)S(0.689)EDNLYLAVLR;RTS(0.001)S(0.999)EDNLYLAVLR 188.16 4.6949e-05 13639400.0 15914.1 29325.0 26234.0 25938.0 23834.0 13320.599999999999 9170.8 10684.400000000001 6423.2 27275.0 True False 15029.658031189838 31574.133205263242 24546.13300141952 22405.199654454278 20839.759841336563 15155.3917376326 9597.260371595457 10715.489835102362 7708.019479203153 26487.49988103938 0.5674245624800761 1.1920390126312013 0.926706299637983 0.8458782352083238 0.786777156580729 0.5721714697762519 0.36233168153652323 0.40454893376980666 0.29100592784601786 1.0 14.693024055667465 -6.7094279932297765 2.06817252321142 0.4631521722780671 0.9079136507730664 0.34523933648518124 0.2309407224383346 0.29894615231028243 2.6288141965728475 0.08605840161205833 0.08196267360560759 1.952414420869408e-07 6.7094279932297765 0.4447614784949993 RTSS(ph)TLDSEGTFNSYR ddPTM_A459_Selumetinib_30min_R2 1 RTSSTLDSEGTFNSYR 16 1 Q92609;Q92609-2;C9JNM0;C9JED7;F2Z3C3;C9K0P2;C9J397;C9JWX0;C9JW04;C9JDR8 Q92609 TBC1D5 TBC1 domain family member 5 1 RT(0.044)S(0.346)S(0.599)T(0.011)LDSEGTFNSYR 90.706 0.021829 7828700.0 14961.0 19217.0 18863.0 24046.0 18753.0 10235.0 11894.0 12179.0 14016.0 24938.0 True False 14129.527513628227 20690.88210760593 17649.37511648154 20770.893318336315 16397.080486052884 11644.778345920577 12447.09456751388 12214.438873658013 16819.591639760783 24217.975143294592 0.5834314153031234 0.854360531183168 0.7287717082890909 0.8576643255861671 0.6770624046409125 0.480832038063461 0.5139609935952963 0.5043542575870515 0.6945085846459689 1.0 14.56379062637994 -4.489796433609465 18.66289050796607 0.6804407875618088 0.18158476022931508 0.03141441510569698 0.16275293725027382 25590047.048968766 378002459.8393524 0.042465334015051356 430363357.0026965 3.237453701936488e-05 4.489796433609465 -0.49885602733249373 RTST(ph)PVIMEGVQEETDTR ddPTM_A459_Selumetinib_30min_R2 1 RTSTPVIMEGVQEETDTR 18 1 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 RT(0.016)S(0.016)T(0.968)PVIMEGVQEETDTR 100.9 0.0033364 3967200.0 7264.1 6855.1 7190.6 8167.5 7477.9 4979.9 4516.5 5756.5 4390.8 7533.6 True False 6860.390402496286 7380.864127379377 6727.964624533323 7055.072410276626 6538.4593487258 5665.836021968725 4726.526199274964 5773.250461960124 5269.08268920246 7316.085393356496 0.937713276108831 1.0088542889455205 0.9196126429364498 0.964323409440124 0.8937100918290493 0.7744354688798042 0.6460457943215059 0.7891174243540992 0.7202051925182756 1.0 12.836856198985043 -6.638616749824751 3.0228234458242635 0.7629070338927263 0.9570324215675753 0.45261986105879226 0.08777244917255965 0.2023538305119194 3.709166498367774 0.029435578658346378 0.029295219923314766 2.2981758158695838e-07 6.638616749824751 0.194125387674849 RTSVPS(ph)PEQPQPYR ddPTM_A459_Selumetinib_30min_R2 1 RTSVPSPEQPQPYR 14 1 Q8TEH3 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 RTSVPS(1)PEQPQPYR 160.93 0.00051532 2659200.0 7488.1 7527.9 9006.2 8893.2 9719.1 6119.8 6921.2 5553.9 6485.4 6608.6 True False 7071.941379239332 8105.265723986398 8426.750897209144 7681.930818374301 8498.099768143582 6962.746899986792 7243.049514097622 5570.06092950236 7782.6612172163605 6417.792546795122 1.1019273882218077 1.2629366974527647 1.3130294935159976 1.1969740003843623 1.3241468474058593 1.0849130521465369 1.128588912976723 0.8679091586224461 1.2126694904002184 1.0 12.647861440354244 -6.888111371100867 5.660526740088479 1.0501305711288371 1.2422682251305663 0.4458718052795144 0.10121365658894464 0.1891232806253145 8.690209905118854 0.03462243965075909 0.030519198950078933 1.2938639985600552e-07 6.888111371100867 0.19213765400172922 RTVQSLEIDLDSMR ddPTM_A459_Selumetinib_30min_R1 1 RTVQSLEIDLDSMR 14 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 105.99 0.007664399999999998 7588600.0 1474.6 2015.2 2079.7 2233.3 1824.5 1595.9 1685.1 1262.8 886.19 921.75 False True 1508.95531092788 1779.2594471589362 1797.2881629743827 1843.296079233089 1659.4742971416385 1579.8466949612623 1557.991550318206 1229.3064418475064 1503.7997052432572 1040.06559110532 1.4508270669008978 1.710718499270844 1.728052709699137 1.7722883008504715 1.59554773404055 1.5189875604694267 1.4979743235832512 1.1819508811372872 1.4458700663725526 1.0 10.022458798584687 -8.011568458281955 0.5754358617680353 1.0304484583412732 1.6857360315408714 0.7232861187383186 0.1217398216190272 0.3910180426627901 0.2961631788006193 0.12060380537850197 0.06421353615117484 9.737142856552255e-09 8.011568458281955 0.6552875731995982 RTYS(ph)DEANQMR ddPTM_A459_Selumetinib_30min_R2 1 RTYSDEANQMR 11 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 RT(0.053)YS(0.947)DEANQMR 144.8 0.0013054 7511800.0 15811.0 21017.0 18587.0 23946.0 22212.0 16893.0 13383.0 13170.0 9616.9 19215.0 True False 14932.28791644784 22628.936319693716 17391.132655995458 20684.51349084593 19421.529982200536 19219.857410614197 14005.336017911412 13208.322519589123 11540.54871863694 18660.213023434335 0.8002206565217236 1.212683707912406 0.9319900386000358 1.1084821735351782 1.040798942531369 1.0299913182382772 0.7505453448105271 0.707833426285194 0.6184575012162936 1.0 14.187677835519297 -7.263943337031066 7.458803774409461 0.7442805009508929 1.0305644846294488 0.4461000873090154 0.13589911593196322 0.1014376329745356 47.46787256504227 0.0511066632250804 0.036645992023303785 5.4457369945019556e-08 7.263943337031066 0.2862839836785559 RTYS(ph)LTTPAR ddPTM_A459_Selumetinib_30min_R2 1 RTYSLTTPAR 10 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 RT(0.002)YS(0.967)LT(0.03)T(0.002)PAR 87.831 0.016994 3494400.0 7614.9 8169.0 10170.0 9424.1 7726.5 7934.8 7302.2 9561.2 5992.0 9745.6 True False 7191.694342859946 8795.536032524999 9515.673272258768 8140.521322520724 6755.827994213601 9027.746675057222 7641.766769034794 9589.021509058128 7190.567430468503 9464.219205890276 0.7598824780372826 0.9293461870632596 1.005436694274417 0.8601365992721599 0.7138283515251798 0.9538818235992035 0.8074376346100229 1.0131867511152084 0.7597634072120061 1.0 13.208267773765446 -10.60817311305039 5.63411870686786 1.0000008896946713 0.8732927594603154 0.1319930442331566 0.10117243576517466 1.0957902821352223e-06 1.7789699660414295e-07 0.09493614570898305 0.023025235838798355 2.4650565512730966e-11 10.60817311305039 -0.1267081302343559 RVAAPQDGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 RVAAPQDGSPR 11 1 Q9HD15 Q9HD15 SRA1 Steroid receptor RNA activator 1 1 RVAAPQDGS(1)PR;RVAAPQDGS(1)PR 103.3 0.0068948 4905500.0 15543.5 16110.699999999999 21144.2 20950.6 20064.5 14355.9 16305.9 21325.6 14833.5 22332.0 True False 14679.654495560488 17346.338885934696 19783.80519206431 18097.092138199154 17543.818131094125 16333.29491511492 17064.15665952789 21387.65396535687 17800.61448261925 21687.21713449574 0.6768805054388926 0.7998416199902185 0.9122334631212845 0.8344589361543245 0.808947410001668 0.7531300495504858 0.7868301660698367 0.986187108872425 0.8207883184009603 1.0 14.40455732034944 -14.522878745280332 0.08962103919447169 1.5932204538097021 0.673970663751034 0.4216603814849398 0.07298436494534069 233.5939122191749 1.4502664109737387 26.259431293128348 1.849560552317123 3.000000000000038e-15 14.522878745280332 -0.9192497900586681 RVAFISLS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 RVAFISLSPVR 11 1 Q6ZU65-2;Q6ZU65 Q6ZU65-2 UBN2 Ubinuclein-2 1 RVAFIS(0.011)LS(0.989)PVR;RVAFIS(0.005)LS(0.995)PVR 104.55 0.0062661 43941000.0 5054.700000000001 4178.8 7750.4 7656.4 5956.0 5112.1 5167.6 5015.3 3370.6000000000004 3502.7 True False 5172.464675265938 3689.5441533285866 6697.938249899813 6319.353468427984 5417.280851617208 5060.676915415424 4777.803771541375 4882.277952009662 5719.662021116155 3952.305664187256 1.3087208112810762 0.9335169055269152 1.6946913571466298 1.5989030215170574 1.3706634334242989 1.280436622417991 1.2088649455516929 1.235298675466601 1.4471709698324497 1.0 11.94847881133022 -6.823971627236071 3.8764611532217663 1.2433806213277434 1.3866054598980504 0.10778672948668921 0.2129843603754623 0.6421909715906996 19.33653311052902 0.0820345192822622 0.07365476458816135 1.4997828141678318e-07 6.823971627236071 0.143224838570307 RVAFISLS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 RVAFISLSPVR 11 1 Q6ZU65-2;Q6ZU65 Q6ZU65-2 UBN2 Ubinuclein-2 1 RVAFISLS(1)PVR;RVAFIS(0.003)LS(0.997)PVR 101.72 0.0076958 12510600.0 33579.0 43241.0 44923.0 51795.0 47681.0 31090.0 28486.1 25296.4 20289.1 45455.0 True False 31712.813607387376 46557.44565827072 42032.70308846421 44740.43164864135 41690.88650645164 35372.365293079725 29810.760094136294 25370.008335955543 24347.48692481952 44142.59604372666 0.7184175025857876 1.054705654650487 0.9522027894967382 1.0135432815125438 0.9444593259796862 0.8013204583174187 0.6753286568059211 0.5747285073769695 0.5515644549020509 1.0 15.429883857134284 -6.9948727899766565 2.5471096606924406 0.6649995923857428 0.9491308653184037 0.3700714209031647 0.14219569268983753 0.2576895226838347 3.3667186095600345 0.056332985513720034 0.04511284960687809 1.011875801322989e-07 6.9948727899766565 0.28413127293266094 RVEIMEEESEQ ddPTM_A459_Selumetinib_30min_R2 1 RVEIMEEESEQ 11 1 A6NJA2;P54578-2;P54578-3;P54578 A6NJA2 USP14 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 14 0 109.44 0.013579 0.0 12722.0 9696.0 15153.0 13101.0 17154.0 10026.0 10665.0 12121.0 11114.0 13514.0 False True 12014.96217020109 10439.652022446127 14178.07247733895 11316.621199514435 14998.961161294268 11406.99049303368 11160.943632296585 12156.270103260433 13337.110551105967 13123.81570641123 0.9155082972044142 0.7954738359626737 1.0803315738739532 0.8622965647091535 1.1428811175675833 0.8691824655432453 0.8504343463802417 0.9262755874666746 1.016252502280304 1.0 13.679899619350985 RVGDPPQPLPEEPMEVQGAERAS(ph)PEPQR ddPTM_A459_Selumetinib_30min_R1 2 RVGDPPQPLPEEPMEVQGAERASPEPQR 28 2 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 RVGDPPQPLPEEPMEVQGAERAS(1)PEPQR;RVGDPPQPLPEEPMEVQGAERAS(1)PEPQR 91.555 1.2834e-05 25560000.0 3045.3 3940.3999999999996 3261.7 3536.4 3518.5 3101.2 3816.3999999999996 3278.9 1381.95 2802.51 True False 3116.2495648777112 3479.0561361577397 2818.7790552356287 2918.8341264495984 3200.25229624163 3070.004743664309 3528.525875398731 3191.932920631763 2345.068216365476 3162.2394572590947 0.9854565433759891 1.1001874409514987 0.8913869722183645 0.9230275461111125 1.0120208603732632 0.9708324702030215 1.115831335068192 1.009390011026681 0.7415846421694103 1.0 11.626730903060436 -8.204298263901535 24.985147358944698 0.8707914668376457 1.001256264896392 0.26346409606608856 0.08709325845525659 312.8535466376781 136796.45916380972 0.05770138096844491 0.021809048311285804 6.247434853176694e-09 8.204298263901535 0.13046479805874633 RVGDPPQPLPEEPMEVQGAERAS(ph)PEPQR ddPTM_A459_Selumetinib_30min_R2 4 RVGDPPQPLPEEPMEVQGAERASPEPQR 28 2 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 RVGDPPQPLPEEPMEVQGAERAS(1)PEPQR;RVGDPPQPLPEEPMEVQGAERAS(1)PEPQR;RVGDPPQPLPEEPMEVQGAERAS(1)PEPQR;RVGDPPQPLPEEPMEVQGAERAS(1)PEPQR 92.426 3.2594e-06 160733000.0 220906.0 214731.0 258605.0 251748.0 263986.0 178963.0 155458.0 162124.0 134620.0 235125.0 True False 208628.9288767835 231200.17723101025 241966.6358478348 217459.48811047708 230821.71861521664 203613.52878563592 162687.1050341831 162595.75399892702 161547.76159707454 228336.33032188375 0.9136913454932077 1.012542230599438 1.0596939852135512 0.9523648199299968 1.0108847693655638 0.8917263779206913 0.7124889184513234 0.712088846175802 0.7074991586723938 1.0 17.800800897754414 -7.02589158312485 3.534703477651567 0.7602206166746975 0.9919646053961461 0.5406915947787536 0.08860198318427023 0.1598940792373961 4.190837814088017 0.033287012108444335 0.0266817087497244 9.421247583272628e-08 7.02589158312485 0.23174398872144852 RVNDAEPGS(ph)PEAPQGK ddPTM_A459_Selumetinib_30min_R1 4 RVNDAEPGSPEAPQGK 16 1 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 1 RVNDAEPGS(1)PEAPQGK;RVNDAEPGS(1)PEAPQGK;RVNDAEPGS(1)PEAPQGK;RVNDAEPGS(1)PEAPQGK 136.33 0.00021055 326097000.0 26563.899999999998 29521.0 36444.399999999994 39614.7 31763.4 26743.1 28139.4 26576.5 14194.4 21104.3 True False 27182.787185648373 26064.667596059426 31495.450654759585 32696.73630501723 28890.40607828375 26474.088694791993 26016.822402839076 25871.604887361635 24086.860082042112 23813.24247829021 1.1414987778514443 1.0945450885078658 1.3226023580565731 1.3730484764863846 1.2132075715695683 1.111738089381469 1.092535904195231 1.0864377209843628 1.0114901447797944 1.0 14.539476454960573 -6.917423115127979 2.3085262305283125 1.0543286202535167 1.2359337359800129 0.5429157011473031 0.07910320724889747 0.27828538590957125 3.013312684470094 0.03659453013211429 0.030560453602756683 1.2094192722754132e-07 6.917423115127979 0.18160511572649618 RVNDAEPGS(ph)PEAPQGK ddPTM_A459_Selumetinib_30min_R2 1 RVNDAEPGSPEAPQGK 16 1 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 1 RVNDAEPGS(1)PEAPQGK 90.755 0.006220600000000001 97196000.0 105120.0 94508.0 115730.0 119290.0 107730.0 83767.0 78125.0 86227.0 72720.0 112920.0 True False 99277.85122870139 101756.45970888386 108284.0577972966 103042.49621327178 94195.99428158044 95305.14388888415 81757.9673017506 86477.9062943517 87266.03196656695 109659.70619860549 0.9053266205993526 0.9279293483113296 0.9874552974014225 0.9396568692847924 0.8589845582020929 0.8690990263668618 0.7455606998771103 0.7886023890829229 0.7957894015192674 1.0 16.742673987906187 -6.500069387734844 1.9602326167546766 0.8184476740779832 0.9432116376738003 0.3150058129948976 0.06748709155192525 0.3336811583501214 2.5731353505333057 0.024176945109125558 0.026623468544542842 3.1617724597453796e-07 6.500069387734844 0.1247639635958171 RVNNGNTAPEDS(ph)SPAK ddPTM_A459_Selumetinib_30min_R1 2 RVNNGNTAPEDSSPAK 16 1 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 RVNNGNT(0.011)APEDS(0.951)S(0.038)PAK;RVNNGNTAPEDS(0.5)S(0.5)PAK 130.47 0.0013915999999999998 1916900.0 1259.57 1295.65 2033.02 2131.6 1432.73 1637.28 1323.46 1150.3 753.46 1080.98 True False 1288.9155303034238 1143.9546956686568 1756.9470505794948 1759.35607508765 1303.1398244690258 1620.8104497312968 1223.6303466762413 1119.7903072990082 1278.5665894589026 1219.7343126368635 1.056718268027569 0.9378720298485465 1.4404342260252287 1.4424092663952477 1.0683800652060476 1.3288225418758395 1.0031941661384889 0.9180608397235355 1.0482336818867164 1.0 10.252351213118452 -7.3491499225080075 7.24074251807513 0.9833419804764322 1.2139572674732289 0.31899567481655433 0.15741163994518828 0.3607271886069136 25.966721303956998 0.07120312720286108 0.04779416075829643 4.475587760394934e-08 7.3491499225080075 0.23061528699679668 RVNNGNTAPEDS(ph)SPAK ddPTM_A459_Selumetinib_30min_R2 2 RVNNGNTAPEDSSPAK 16 1 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 RVNNGNTAPEDS(0.5)S(0.5)PAK;RVNNGNTAPEDS(0.593)S(0.407)PAK 73.735 0.01741 6316500.0 48265.0 44592.0 46239.0 52452.0 48783.0 38416.0 44735.0 48380.0 35933.0 47660.0 True False 45582.62452010338 48012.063014121035 43264.03308121664 45307.947115253104 42654.44341444664 43707.455294273095 46815.266140720814 48520.77779025986 43120.604051906674 46283.931964448675 0.9848477124872628 1.0373376024102654 0.934752758569612 0.9789130955869255 0.9215821042864316 0.9443332370258731 1.0114798841351738 1.048328776983108 0.9316538639160606 1.0 15.498223810646767 -7.275611020171417 24.650241197166995 1.0018930306362461 0.9671765944333357 0.12079336129598217 0.04026148749033877 1433.2601993875087 2493012.054732645 0.017249781365949884 0.011699485423664464 5.3013805431698496e-08 7.275611020171417 -0.03471643620291043 RVNNGNTAPEDS(ph)SPAKK ddPTM_A459_Selumetinib_30min_R2 1 RVNNGNTAPEDSSPAKK 17 2 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 RVNNGNTAPEDS(0.627)S(0.373)PAKK 104.84 0.0030719 3688200.0 6202.2 3629.9 6095.4 7453.9 4578.1 4608.6 4129.2 3899.2 3542.1 4685.6 True False 5857.506553373772 3908.301658031887 5703.228600169729 6438.665961305293 4002.9581492667144 5243.39281729454 4321.215981854574 3910.546026452689 4250.618974543143 4550.314553349151 1.287275084985607 0.8589080188215285 1.2533701864571107 1.4149935978747374 0.8797102051594284 1.1523143632862185 0.9496521462838313 0.8594012525077909 0.9341373930763921 1.0 12.151750563791287 -6.959636271511779 1.308105465630893 0.922110043162698 1.1623281576326905 0.27891495251668563 0.16298221245037475 0.6074371825676734 2.135559064772576 0.08808107768170233 0.0664355019822335 1.0973968986114043e-07 6.959636271511779 0.24021811446999253 RVNNGNTAPEDSS(ph)PAKK ddPTM_A459_Selumetinib_30min_R1 1 RVNNGNTAPEDSSPAKK 17 2 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 RVNNGNTAPEDS(0.263)S(0.737)PAKK 83.948 0.014369 11809000.0 1560.8 1475.6 2318.7 2080.8 1637.6 1442.1 1366.9 1708.2 1063.3 1522.1 True False 1597.163603211877 1302.8360660121707 2003.8332757074088 1717.4273414535478 1489.479369141763 1427.5937833220366 1263.7936325024968 1662.8929869844083 1804.3424396406588 1717.4763615095278 0.929947939317252 0.758575835574866 1.1667312113374275 0.9999714580898587 0.8672488323697375 0.8312159720598966 0.7358433925644955 0.9682188496165706 1.0505777430641214 1.0 10.746074527305074 -7.995174740375533 24.99567270622987 1.0199920551426735 0.8998717684132509 0.16289372170706795 0.11667106574951115 248.14533139554337 1285437.3371992751 0.06875293418030647 0.03283015221375874 1.0111725225004715e-08 7.995174740375533 -0.12012028672942265 RVPGSS(ph)GHLHK ddPTM_A459_Selumetinib_30min_R2 1 RVPGSSGHLHK 11 1 Q9UEW8-2;Q9UEW8 Q9UEW8-2 STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 RVPGS(0.014)S(0.986)GHLHK 84.365 0.025009 82194000.0 373880.0 402070.0 561210.0 666970.0 627600.0 344080.0 426510.0 421460.0 430480.0 605390.0 True False 353101.2463602247 432907.476141184 525102.3595992486 576127.5354125751 548755.2771848125 391473.89675274614 446343.5601135313 422686.3788235412 516588.02861616894 587910.8177078798 0.6006034176014653 0.7363488867733105 0.893166690904743 0.979957364381821 0.9333988432535989 0.6658729265758485 0.7592028359908658 0.7189634313440461 0.8786843396252157 1.0 19.165237798531194 RVPLS(ph)PLSLLAGPADAR ddPTM_A459_Selumetinib_30min_R1 2 RVPLSPLSLLAGPADAR 17 1 Q53ET0;H0YDQ8;Q5T4K5 Q53ET0 CRTC2 CREB-regulated transcription coactivator 2 1 RVPLS(0.992)PLS(0.008)LLAGPADAR;RVPLS(0.996)PLS(0.004)LLAGPADAR 95.996 0.0031677 17967000.0 1854.44 2047.8500000000001 3307.6 3597.8999999999996 2758.2 2148.43 2327.77 2280.73 1633.4700000000003 1497.3200000000002 True False 1897.6448438879006 1808.0867699803628 2858.4460873462826 2969.5943059475785 2508.72129699976 2126.8187448183626 2152.184434801621 2220.237631544871 2771.8792860715025 1689.5156071318872 1.1231887032457382 1.0701805667541369 1.6918731471198218 1.7576601798835976 1.484876071229997 1.258833440685901 1.273847027939066 1.3141267367834113 1.6406355018981034 1.0 10.72239396231845 -6.758335173556182 24.987785418609185 1.3156438669925825 1.439058329929138 0.05895879840327711 0.24770819614006814 304.79218335653997 2453479.329353014 0.09058806768941484 0.08691960215597992 1.744475307171235e-07 6.758335173556182 0.12341446293655545 RVPPPALS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 RVPPPALSR 9 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 RVPPPALS(1)R;RVPPPALS(1)R 72.73100000000002 0.034165 25215000.0 3951.6 5165.6 4121.2 4118.3 4444.6 4302.2 5342.4 5089.5 2451.6000000000004 3613.7000000000003 True False 4043.6645915248973 4560.80915057771 3561.563676131185 3399.1162150654313 4042.586714757863 4258.9237740850585 4939.418466809083 4954.509926974098 4160.186142220483 4077.5535954188185 0.9916888881774611 1.1185160522971016 0.8734560056139165 0.8336165633443494 0.9914245441923213 1.0444801458575583 1.2113681282714666 1.215069234783462 1.0202652264079382 1.0 11.993488124526722 -6.911949326630919 3.14980413310491 1.1295434189851434 0.9577268198370854 0.33981409002718943 0.09689525736000104 0.27479841143350703 5.472001410601512 0.038948261398417 0.033413229419393724 1.2247590955063802e-07 6.911949326630919 -0.17181659914805802 RVPPPALS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 RVPPPALSR 9 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 RVPPPALS(1)R;RVPPPALS(1)R 80.17 0.024173 40956000.0 24007.0 20226.4 27770.0 30238.0 30348.0 20617.3 21938.0 29569.0 22729.1 25250.0 True False 22672.787047635393 21777.69984187337 25983.308433689876 26119.53223654053 26535.412925437697 23457.145929784885 22958.1604693223 29655.04089458853 27275.55510411579 24520.966892621258 0.9246285901743128 0.8881256574114385 1.0596363735358518 1.0651917744891335 1.082151982082836 0.9566158639871377 0.9362665252906798 1.2093748596639635 1.1123360356692717 1.0 14.581728246983015 -5.264459501277347 24.778007377871194 1.0540829055854535 0.9063771164273683 0.3818727743390107 0.07444652963358618 233.00006960728916 1911623.766516881 0.020820950132878505 0.04656068410445013 5.4392685148904625e-06 5.264459501277347 -0.1477057891580852 RVPPPALS(ph)RDR ddPTM_A459_Selumetinib_30min_R1 1 RVPPPALSRDR 11 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 RVPPPALS(1)RDR 99.669 0.019247 10134000.0 1656.3 2135.9 3148.9 3430.2 2471.5 2502.3 2365.1 2052.0 1282.0 1719.4 True False 1694.8885674012256 1885.8278350470296 2721.296675669582 2831.1799628286994 2247.9532613787655 2477.1291339066165 2186.698602847067 1997.5742941646208 2175.4603664246465 1940.1017383742744 0.8736080865643019 0.9720252282373995 1.4026566864219794 1.459294585860797 1.1586780305977449 1.2768037288510183 1.127105120105418 1.0296234752299671 1.1213125185113193 1.0 10.921916593569069 -7.522613476383839 5.536212632783719 1.0592405625821761 1.2013888938022168 0.11995095325088456 0.16819015025372244 0.39947060225915704 42.742124726015476 0.08584925916076232 0.051870894133765465 3.0018329723567645e-08 7.522613476383839 0.14214833122004067 RVPPPALS(ph)RDR ddPTM_A459_Selumetinib_30min_R2 2 RVPPPALSRDR 11 2 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 RVPPPALS(1)RDR;RVPPPALS(1)RDR 67.51899999999999 0.029188 3148200.0 4823.200000000001 8441.900000000001 7958.6 9419.1 10592.4 4814.299999999999 3069.8 3162.9 3868.27 8713.7 True False 4555.145852799393 9089.366585013197 7446.552340668501 8136.2023311462035 9261.688014742527 5477.426125135856 3212.551782693299 3172.103515353716 4642.032088494395 8462.112840088463 0.5382988786464555 1.0741249563528836 0.8799873602950743 0.9614859178669553 1.09448883390755 0.64728823978653 0.37963944033860403 0.3748595150287023 0.5485665549746873 1.0 13.046802208450256 -6.9415118805769875 6.11013117450694 0.5219161730403735 0.9183555261380136 0.342319540467109 0.21786300123005098 0.1867237075922591 14.097131620983633 0.0743794460045967 0.0652063736637431 1.1441635796048219e-07 6.9415118805769875 0.3964393530976401 RVPS(ph)INQK ddPTM_A459_Selumetinib_30min_R2 1 RVPSINQK 8 1 Q92834-2;Q92834;A0A2R8YFT6;Q92834-4 Q92834-2 RPGR X-linked retinitis pigmentosa GTPase regulator 1 RVPS(1)INQK 70.41199999999998 0.036667 11135000.0 77601.0 80304.0 79532.0 84682.0 100410.0 51852.0 66785.0 59414.0 52169.0 74727.0 True False 73288.24708141608 86463.05858194242 74414.99770789416 73148.16551540204 87795.59812321073 58994.14233440876 69890.63483196685 59586.8849034828 62604.25772365012 72569.43734593678 1.0099051303381719 1.1914527898263159 1.0254316476667669 1.0079748195746163 1.2098150589853853 0.8129337155142197 0.9630863540914594 0.8211016521932442 0.8626807649784731 1.0 16.147074463955626 -6.770422715143573 24.99996473035634 0.885224707842045 1.086588761839123 0.5764676789170495 0.08429933604999137 134.89134953395015 375390.3870458144 0.028201635043158497 0.025223739099117664 1.6965914922661724e-07 6.770422715143573 0.20136405399707802 RVPS(ph)PTPAPK ddPTM_A459_Selumetinib_30min_R1 4 RVPSPTPAPK 10 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RVPS(0.991)PT(0.009)PAPK;RVPS(0.974)PT(0.026)PAPK;RVPS(0.966)PT(0.034)PAPK;RVPS(0.994)PT(0.006)PAPK 109.16 0.010577 2219298000.0 29859.7 33563.0 36782.6 39301.399999999994 33481.4 27619.0 32662.299999999996 30151.000000000004 17450.2 26160.6 True False 30555.372913137937 29633.428356984612 31787.72495235924 32438.148268647874 30453.013281621268 27341.177936045573 30198.55641443139 29351.29753574928 29611.714887818525 29518.56783582298 1.0351238272493937 1.0038911278419895 1.0768721954654747 1.0989065746367872 1.0316561918246003 0.9262366009120881 1.0230359610395188 0.9943333870056288 1.0031555410314488 1.0 14.849335106832655 -6.534211470051476 24.99684026701064 0.9897525811391837 1.0534817099903162 0.46327407332917303 0.032946117626910555 209.17888235544336 461387.21769340965 0.011291020715571143 0.011299553224313792 2.922728873393861e-07 6.534211470051476 0.06372912885113247 RVPS(ph)PTPAPK ddPTM_A459_Selumetinib_30min_R2 6 RVPSPTPAPK 10 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 RVPS(0.987)PT(0.013)PAPK;RVPS(0.978)PT(0.022)PAPK;RVPS(0.989)PT(0.011)PAPK;RVPS(0.981)PT(0.019)PAPK;RVPS(0.996)PT(0.004)PAPK;RVPS(0.993)PT(0.007)PAPK 117.2 0.01095 3651080000.0 1141010.0 1395538.0 1123160.0 1327342.0 1301829.0 874016.0 984467.0 1000794.0 822151.0 1061620.0 True False 1077597.2320249279 1502571.277238077 1050897.1084041446 1146555.7298073326 1138281.6025210777 994403.7704727029 1030246.6661843534 1003706.1448496338 986604.1728182775 1030968.2721799806 1.0452283170134329 1.4574369723918783 1.0193302129288853 1.112115436281024 1.1040898476091638 0.9645338244697268 0.9993000696383203 0.9735567736990576 0.9569685114868809 1.0 19.97556850409331 -5.995434684000783 0.8668486581415756 0.9749338933471666 1.238652731270998 0.38103051514914077 0.11094752236109609 0.6589141274995174 0.9947661769479271 0.04964846437293842 0.11611603366636097 1.0105674740480686e-06 5.995434684000783 0.26371883792383144 RVQS(ph)LPSVPLSCAAYR ddPTM_A459_Selumetinib_30min_R2 2 RVQSLPSVPLSCAAYR 16 1 Q96AD5-2;Q96AD5 Q96AD5-2 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 RVQS(0.994)LPS(0.006)VPLSCAAYR;RVQS(0.972)LPS(0.028)VPLSCAAYR 89.65899999999998 0.0066638 10072600.0 11184.3 13617.7 15142.7 15464.4 15654.7 9715.1 10433.4 9834.5 5929.3 14189.2 True False 10562.721380300263 14662.133802193119 14168.435168125168 13358.122042422025 13688.016631206321 11053.266840102882 10918.573773389888 9863.116766810876 7115.325678484132 13779.52092803095 0.7665521490528077 1.0640525079770164 1.0282240755774803 0.9694184661564179 0.9933593992634036 0.8021517509812556 0.7923768780073341 0.7157808183843939 0.5163695977274364 1.0 13.750238110351559 -6.960175855965801 2.0850270500300265 0.7281027400410052 0.9755905998162604 0.3475333695256767 0.13385183856541433 0.3205574559102194 2.8178663007496083 0.05587661089071017 0.04483565305912144 1.0960342964245504e-07 6.960175855965801 0.24748785977525523 RVQT(ph)PLLR ddPTM_A459_Selumetinib_30min_R1 1 RVQTPLLR 8 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 1 RVQT(1)PLLR 102.05 0.020642 21000000.0 2687.5 2895.8 2903.9 3143.6 3023.9 2398.4 2998.0 2430.9 1348.8 2075.6 True False 2750.1135210353164 2556.758389779103 2509.566329980915 2594.6292726803995 2750.3887789129076 2374.2742735729653 2771.8584462963527 2366.424635323967 2288.815087545679 2342.02347805609 1.1742467771151237 1.0916877707397048 1.0715376483176366 1.1078579258453787 1.1743643070545844 1.013770483438383 1.1835314514425925 1.0104188354627983 0.9772810174582133 1.0 11.193539823142254 -7.898023937991618 7.182124505571647 0.9904954711316855 1.111722862504103 0.5523967166344068 0.0499166577809353 0.16090577256032995 9.821216682589391 0.026172199551082295 0.012472883039987245 1.2646666380574082e-08 7.898023937991618 0.12122739137241745 RVS(ph)EVEEEKEPVPQPLPSDDTR ddPTM_A459_Selumetinib_30min_R1 3 RVSEVEEEKEPVPQPLPSDDTR 22 2 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 RVS(0.985)EVEEEKEPVPQPLPS(0.014)DDT(0.001)R;RVS(1)EVEEEKEPVPQPLPSDDTR;RVS(0.961)EVEEEKEPVPQPLPS(0.037)DDT(0.002)R 83.73299999999998 0.00084346 115304000.0 3858.3999999999996 4973.7 4048.8999999999996 3736.74 4351.5 4036.6 4785.1 4583.5 2982.66 3472.7700000000004 True False 3948.293212860527 4391.376891789602 3499.0816190157116 3084.1885062971605 3957.9075933197237 3995.9954689395527 4424.156054493886 4461.930690693732 5061.356175132708 3918.5338571443676 1.0075945128461508 1.120668355023432 0.8929568421709818 0.7870771616976059 1.0100480785954085 1.0197680088061394 1.1290335150295192 1.138673507326887 1.2916453856599244 1.0 11.936098246991214 -7.157730514827829 1.9400523693799214 1.1596434859109719 0.9586619549898232 0.39136013015289617 0.1038055432553566 0.3603667072586842 2.663553795536779 0.05317079588369704 0.036480716428697185 6.954557227259274e-08 7.157730514827829 -0.20098153092114868 RVS(ph)EVEEEKEPVPQPLPSDDTR ddPTM_A459_Selumetinib_30min_R2 6 RVSEVEEEKEPVPQPLPSDDTR 22 2 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 RVS(1)EVEEEKEPVPQPLPSDDTR;RVS(1)EVEEEKEPVPQPLPSDDTR;RVS(1)EVEEEKEPVPQPLPSDDTR;RVS(0.999)EVEEEKEPVPQPLPS(0.001)DDTR;RVS(1)EVEEEKEPVPQPLPSDDTR;RVS(1)EVEEEKEPVPQPLPSDDTR 67.579 0.002235 451620800.0 344737.0 286217.2 318339.9 314796.7 347781.3 286864.4 344450.7 371232.1 294174.7 347049.3 True False 325577.8976315523 308169.13890664803 297858.25741627644 271920.84640540276 304089.90388973017 326377.36720424984 360468.3400661134 372312.32395021734 353017.8599278785 337029.08496662846 0.9660231480134421 0.9143695682441234 0.883776121119545 0.8068171517966394 0.9022660578977633 0.9683952565594351 1.069546683491147 1.1046890032861185 1.0474403417225346 1.0 18.362513573044247 -7.020489703605446 2.6315576898875945 1.0641436289293664 0.8902028773881572 0.7431940075908078 0.04434583411814832 0.14303065534523568 1.9844658839986158 0.019513928920451874 0.015410281529008661 9.539163583321311e-08 7.020489703605446 -0.17394075154120925 RVS(ph)FADPIYQAGLADDIDRR ddPTM_A459_Selumetinib_30min_R1 1 RVSFADPIYQAGLADDIDRR 20 2 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 RVS(1)FADPIYQAGLADDIDRR 130.98 0.00018205 6014500.0 673.28 915.48 1050.6 1227.0 1045.2 723.36 1069.0 975.17 538.16 810.24 True False 688.9661140251746 808.2951760048945 907.9342905327143 1012.7274836425913 950.6618445450481 716.0836551583307 988.3644693431618 949.3053238014202 913.2182143487422 914.2421964059391 0.7535925564731448 0.8841149305757899 0.9931003995461789 1.1077234102996085 1.0398358862479566 0.7832537788929371 1.081075095011597 1.0383521210608315 0.9988799663139347 1.0 9.836432597144485 -4.965637805378014 2.282831926922469 1.0065478449976777 0.7374915506956775 0.48418015836302575 0.0825669697811584 0.36905298772241496 3.0577894895388282 0.023073278191215536 0.1725762982755091 1.0823362260316435e-05 4.965637805378014 -0.2690562943020002 RVS(ph)GDAAQDLDR ddPTM_A459_Selumetinib_30min_R1 2 RVSGDAAQDLDR 12 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 RVS(1)GDAAQDLDR;RVS(1)GDAAQDLDR 132.65 0.0033292 22058300.0 4042.5 5875.9 5637.700000000001 5678.700000000001 5220.200000000001 4134.5 3899.0 4209.5 3366.27 4077.8 True False 4136.682384664284 5187.9468963681975 4872.131305669411 4687.021647401127 4748.033831701166 4092.9106838256403 3604.8952908970896 4097.850385616946 5712.314327366847 4601.2253511356375 0.8990392925752487 1.1275141946889757 1.058876915138901 1.0186464017121686 1.0319063878341221 0.889526239529968 0.783464189600572 0.8905998017692283 1.2414767570462462 1.0 12.167802400743387 -6.733100792897886 21.81050404237423 0.9430791853314898 1.034055093165057 0.05681004961743774 0.12296425605895964 124.3087600312911 95671.00481522254 0.0415167320484411 0.041499233372599836 1.8488394827051985e-07 6.733100792897886 0.09097590783356713 RVS(ph)GDAAQDLDR ddPTM_A459_Selumetinib_30min_R2 3 RVSGDAAQDLDR 12 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 RVS(1)GDAAQDLDR;RVS(1)GDAAQDLDR;RVS(1)GDAAQDLDR 85.473 0.016023 58574500.0 88811.3 91453.8 155718.9 163340.6 228199.9 143914.0 114558.1 135393.0 152176.2 160710.5 True False 83875.5234858025 98468.01238968477 145700.11550791928 141093.32850174844 199531.3884290096 163736.84717878018 119885.2786425687 135786.9712144822 182615.6921582884 156070.37028897423 0.5374211859080082 0.6309206046436936 0.9335539810544836 0.9040366101554392 1.278470654356522 1.049121924139803 0.7681488704139899 0.8700368363518584 1.1700855954923657 1.0 17.25183714439457 -5.2343990593528815 2.0029123084210485 1.0036822778797851 0.5236310559561713 0.6000893940201932 0.13705470674949183 0.28373394693740306 2.024981086814132 0.041479990816602086 0.1747038377635949 5.829092414006695e-06 5.2343990593528815 -0.4800512219236138 RVS(ph)GPDPK ddPTM_A459_Selumetinib_30min_R2 1 RVSGPDPK 8 1 P22314;Q5JRR9;Q5JRS2;Q5JRS0;Q5JRS1;Q5JRS3 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 RVS(1)GPDPK 72.289 0.034064 2280300.0 41421.0 29570.0 23297.0 34188.0 34305.0 34510.0 58907.0 84942.0 55320.0 55407.0 True False 39118.986641400625 31837.92391746409 21798.096383855718 29531.53542241046 29995.299209408866 39263.43924941075 61646.29222200604 85189.16715709481 66385.54576994614 53807.25594532538 0.7270206583504315 0.5917031701043302 0.4051144404391333 0.5488392764800725 0.5574582587873964 0.7297052889912675 1.1456873453023895 1.5832282405119713 1.233765680922324 1.0 15.715513113864617 -7.243704732848968 2.637514090506746 1.3151481036582475 0.562052592033919 0.8114829371913773 0.1544439830651317 0.10859811329551806 1.497692575120447 0.06924352298396175 0.04706488289185454 5.70552046082303e-08 7.243704732848968 -0.7530955116243285 RVS(ph)HSPPPKQR ddPTM_A459_Selumetinib_30min_R1 1 RVSHSPPPKQR 11 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RVS(0.998)HS(0.002)PPPKQR 80.23100000000002 0.01729 814020.0 129.86 0.0 331.59 310.4 145.59 42.761 0.0 111.31 0.0 0.0 True False 132.88548533642648 0.0 286.5618992934918 256.19446692963345 132.4214102060022 42.33086316388155 0.0 108.35769721416376 0.0 0.0 0.0 RVS(ph)LSEIGFGK ddPTM_A459_Selumetinib_30min_R1 2 RVSLSEIGFGK 11 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;H0YBX5 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 RVS(0.999)LS(0.001)EIGFGK;RVS(0.967)LS(0.033)EIGFGK 130.66 0.0012074000000000002 173164000.0 25289.0 25853.0 27471.0 26237.0 25593.0 22621.0 25013.0 22798.0 14324.599999999999 19017.300000000003 True False 25878.184496171965 22826.118741266375 23740.589087401662 21655.200479487088 23278.11766881115 22393.45327822465 23126.249271918157 22193.322981659385 24307.799972610348 21458.355699188713 1.205972389447825 1.0637403471753137 1.1063563965574135 1.0091733394234776 1.08480435291187 1.043577317486227 1.0777269981032378 1.0342508667846557 1.1327894976374804 1.0 14.389251909720645 RVS(ph)LSEIGFGK ddPTM_A459_Selumetinib_30min_R2 2 RVSLSEIGFGK 11 1 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;H0YBX5 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 RVS(0.99)LS(0.01)EIGFGK;RVS(0.937)LS(0.063)EIGFGK 108.14 0.0052077 51609000.0 216454.0 221346.0 246078.0 265100.0 291600.0 237062.0 247962.0 253325.0 205452.0 254456.0 True False 204424.3532140153 238322.5264604334 230245.6093894682 228992.92267699246 254966.60106292478 269715.1386654248 259492.72432738147 254062.1338097889 246548.140808514 247109.19412391464 0.8272632426274892 0.9644421661661238 0.9317565467596884 0.9266871817086755 1.031797307125165 1.0914816003575092 1.0501135955194651 1.0281371144870783 0.9977295328189234 1.0 17.91478916406026 -6.251731826947399 4.44743039783504 1.039100871366258 0.9161435435910783 0.6758927033029063 0.0408769450930479 0.12338740844072234 6.421541847295403 0.01270951788772368 0.01572705300014838 5.601033536676639e-07 6.251731826947399 -0.12295732777517965 RVS(ph)LTQR ddPTM_A459_Selumetinib_30min_R2 2 RVSLTQR 7 1 Q96I34 Q96I34 PPP1R16A Protein phosphatase 1 regulatory subunit 16A 1 RVS(0.996)LT(0.004)QR;RVS(0.973)LT(0.027)QR 80.23100000000002 0.023244 9058700.0 17920.0 9550.6 20356.2 19281.5 17575.1 12198.900000000001 20441.5 19056.5 19709.2 17282.6 True False 16924.07813944376 10283.100309980806 19046.504254154774 16655.326437557247 15367.158814612498 13879.187744411396 21392.070254063823 19111.951260026595 23651.590721059743 16783.606432412507 1.008369578230813 0.6126871689580422 1.1348278649678152 0.9923568277549976 0.9156052887974919 0.826949070827108 1.2745812611973222 1.1387273252021441 1.4092078967833626 1.0 14.034765132461445 -7.264984059049783 24.859103345672544 1.2171897430944107 0.914902931445016 0.44136657859265593 0.15989539047244414 264.880203853288 1857611.8614080201 0.06335226163912237 0.04463663983053339 5.432702720760361e-08 7.264984059049783 -0.30228681164939475 RVS(ph)LVGADDLR ddPTM_A459_Selumetinib_30min_R1 4 RVSLVGADDLR 11 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 RVS(1)LVGADDLR;RVS(1)LVGADDLR;RVS(1)LVGADDLR;RVS(1)LVGADDLR 94.45 0.011398 37327200.0 12934.900000000001 14130.0 16417.4 14283.000000000002 16567.3 14544.2 14405.800000000001 13550.0 6510.9 11454.8 True False 13236.25800306594 12475.653031141215 14188.00725432304 11788.742175115834 15068.790640194384 14397.898553077008 13319.158907823881 13190.60998339699 11048.5217626788 12925.135159200665 1.0240711481955995 0.96522418353672 1.0977066838812441 0.9120788316649906 1.165851687784307 1.1139456861174846 1.0304850776235583 1.0205394234510072 0.8548089924470916 1.0 13.657891746549156 -8.088193998077397 6.477904062405103 0.9280745730135033 1.0441939046270197 0.2697455191821828 0.07574975805727284 0.3223202741078626 19.548100704102435 0.051673860573131954 0.019254105112796443 8.162176878544342e-09 8.088193998077397 0.1161193316135164 RVS(ph)LVGADDLR ddPTM_A459_Selumetinib_30min_R2 1 RVSLVGADDLR 11 1 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 RVS(1)LVGADDLR 120.21 0.002463 18780000.0 83960.0 51764.0 69999.0 76945.0 61458.0 51410.0 94053.0 65769.0 53525.0 68406.0 True False 79293.83931850988 55734.13235250633 65495.34054914868 66464.95826247155 53737.09659850895 58491.260846485304 98426.65086248376 65960.37690135585 64231.49561345579 66430.94103986718 1.193628120831877 0.8389785163371181 0.9859161939290154 1.000512068955699 0.8089166848661639 0.8804821959602073 1.481638665985704 0.9929164914549543 0.9668912498907484 1.0 16.019567730876112 RVS(ph)PLNLSSVT(ph)P ddPTM_A459_Selumetinib_30min_R2 1 RVSPLNLSSVTP 12 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 2 RVS(1)PLNLSSVT(1)P 122.33 0.035159 3261200.0 18224.0 15358.0 18412.0 21259.0 22706.0 16419.0 18031.0 16311.0 15580.0 17904.0 True False 17211.183036452167 16535.90921624665 17227.39196546986 18363.487526179488 19853.4692857845 18680.56821315779 18869.477227748688 16358.462309568586 18696.435341571974 17387.064999821407 0.9898843212830316 0.9510466094430833 0.9908165619468733 1.0561579844768574 1.1418528248435504 1.0743945693738228 1.0852594861721923 0.9408409245457249 1.075307151711 1.0 14.085726800545526 -5.689720291521596 4.169913921850061 1.0569796705831729 0.9710287119910683 0.3199077682252668 0.051167882973087 0.25591403790267414 8.580697146954819 0.014983510919961224 0.026468191789709102 2.0430533547968598e-06 5.689720291521596 -0.08595095859210455 RVS(ph)PLNLSSVTP ddPTM_A459_Selumetinib_30min_R1 3 RVSPLNLSSVTP 12 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 RVS(0.988)PLNLS(0.012)SVTP;RVS(0.994)PLNLS(0.005)S(0.001)VTP;RVS(0.876)PLNLS(0.124)SVTP 132.59 0.0033445 460212000.0 11796.1 13515.400000000001 15591.9 16792.0 14283.3 12637.1 14498.400000000001 13028.3 7329.900000000001 10654.2 True False 12070.926178785005 11933.010684861007 13474.60562017611 13859.592424878883 12991.378036921431 12509.982247568754 13404.7740152712 12682.747162117423 12438.304945285507 12021.770350696288 1.0040889009401073 0.9926167558316283 1.1208503595641948 1.1528744952340693 1.0806543177868129 1.04061064906669 1.1150415973879262 1.0549816534619505 1.0346483573082972 1.0 13.553361745490534 -10.354120975170252 14.93960768514096 1.0000000001329319 1.0690215109704624 0.13822407845282503 0.04920412775733234 0.0 0.0 0.051566065839946156 0.012506608009156041 4.4246510405188275e-11 10.354120975170252 0.0690215108375305 RVS(ph)PLNLSSVTP ddPTM_A459_Selumetinib_30min_R2 3 RVSPLNLSSVTP 12 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 RVS(0.999)PLNLS(0.001)SVTP;RVS(0.988)PLNLS(0.012)SVTP;RVS(0.793)PLNLS(0.158)S(0.049)VTP 146.5 0.0011756 41863100.0 231913.0 198172.0 239186.0 271325.0 279580.0 183786.0 191582.0 208094.0 179247.0 221612.0 True False 219024.20388129592 213371.1551765873 223797.03316602655 234370.06693826866 244456.66092308756 209100.85325680109 200490.9426125312 208699.51908818402 215101.4085796373 215213.4857428739 1.0177066884320385 0.9914395208091759 1.0398838734177087 1.0890119925769062 1.1358798454440346 0.9715973538322972 0.9315909824167224 0.9697325349654323 0.9994792279728674 1.0 17.715408957558033 -6.935140867210291 24.999008744468863 0.9696660211688908 1.0524792821895137 0.4898953430072004 0.04079535944971264 55.82671038072385 21517.033673057416 0.01595431883865119 0.01407038985135275 1.1610719489236975e-07 6.935140867210291 0.08281326102062292 RVS(ph)PVPFQSGR ddPTM_A459_Selumetinib_30min_R2 1 RVSPVPFQSGR 11 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 RVS(1)PVPFQSGR 63.16 0.044892 4318400.0 10126.0 13029.0 13804.0 10867.0 13339.0 8653.3 8942.5 10829.0 7630.8 11039.0 True False 9563.237457589696 14028.282405161983 12915.86566865881 9386.895853379383 11663.235567826983 9845.213528163606 9358.34396922759 10860.510597162538 9157.173222366333 10720.275387233502 0.8920701299313922 1.3085748171980638 1.204807264936494 0.8756207759884597 1.0879604437882657 0.9183731921558671 0.8729574223785519 1.0130813066701663 0.85419197656726 1.0 13.388054346417247 -5.7579647939172345 24.99973740673059 0.9482886500700752 1.1524931708918762 0.3431183582067623 0.11916516024624152 91.43637538063562 657875.0219797113 0.03160063672419455 0.05203830294466954 1.7459636837322225e-06 5.7579647939172345 0.20420452082180096 RVS(ph)SDEEHTVDSCISDMK ddPTM_A459_Selumetinib_30min_R2 2 RVSSDEEHTVDSCISDMK 18 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;H7C150;H7C183 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 RVS(0.476)S(0.476)DEEHT(0.048)VDSCISDMK;RVS(0.71)S(0.255)DEEHT(0.035)VDSCISDMK 70.358 0.012236 8993600.0 33757.0 29177.0 41647.0 41660.0 39528.0 30449.0 31468.4 33411.0 32888.0 36140.0 True False 31880.921079977834 31414.782081158253 38967.47736182508 35985.83613249153 34562.13925519642 34643.07336149835 32931.742953451634 33508.22047851121 39466.51896749806 35096.544297003216 0.9083777824445254 0.895096161471392 1.1102938520688599 1.0253384443768228 0.984773286016868 0.987079328048158 0.9383186753307667 0.9547441535824476 1.1245129615472707 1.0 15.099041365321094 -5.21431032724599 24.879774177990587 1.009479888131401 0.9017368265376995 0.38264765874171036 0.05744367098379097 430.70725687696364 227371.8155593598 0.014988970423201067 0.03965697468995008 6.105056292267251e-06 5.21431032724599 -0.10774306159370162 RVS(ph)SSAGNAAVIK ddPTM_A459_Selumetinib_30min_R2 2 RVSSSAGNAAVIK 13 1 Q9ULD2-2 Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 RVS(0.962)S(0.038)SAGNAAVIK;RVS(0.756)S(0.242)S(0.002)AGNAAVIK 117.53 0.0018475 18077500.0 96914.0 80420.0 104040.0 108906.0 113680.0 89889.0 95078.0 114899.0 88280.0 116684.0 True False 91527.90785748065 86587.95540894377 97346.17967018687 94072.81492667118 99398.50208790548 102270.39381890133 99499.31539348286 115233.33706744651 105938.46674929257 113315.02973855931 0.8077296371774692 0.7641347807852118 0.8590756221375416 0.8301883266828433 0.8771872744263309 0.9025315887474045 0.8780769472774079 1.016928975205788 0.9349021660561183 1.0 16.789979702684548 -6.77401037800493 0.4265868966489567 1.0046105788451054 0.7673251811539641 0.8003983671211985 0.03395120086527102 0.5382174616703385 0.2046098224753629 0.03265806501110875 0.05097809866160789 1.6826338519686178e-07 6.77401037800493 -0.23728539769114132 RVS(ph)SSSELDLPSGDHCEAGLLQLDVPLLR ddPTM_A459_Selumetinib_30min_R1 2 RVSSSSELDLPSGDHCEAGLLQLDVPLLR 29 1 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 RVS(0.398)S(0.398)S(0.117)S(0.083)ELDLPS(0.004)GDHCEAGLLQLDVPLLR;RVS(0.45)S(0.204)S(0.204)S(0.143)ELDLPSGDHCEAGLLQLDVPLLR 97.388 9.986e-08 21640100.0 3663.5 3130.7 4433.6 5245.1 4079.3 3523.8 3511.0 3070.6 1482.6100000000001 2639.3 True False 3748.8524220699105 2764.156188577055 3831.5414720215504 4329.141747721069 3710.328035258911 3488.353771354409 3246.1624432776835 2989.157713285518 2515.880884449957 2978.079863959067 1.2588152747140153 0.9281672469664325 1.286581168756129 1.4536687884407158 1.245879292950321 1.1713432583090577 1.0900185997571692 1.003719795919685 0.8447996693766764 1.0 11.540166728237152 -7.566400428905307 1.6519557045081832 0.9259246493392612 1.2288793166023166 0.4930516629950612 0.12686882666809574 0.36143420826863615 1.9145916656058726 0.09318595759229208 0.043567302162597715 2.7139358073817807e-08 7.566400428905307 0.3029546672630554 RVS(ph)TDLPEGQDVYTAACNSVIHR ddPTM_A459_Selumetinib_30min_R1 2 RVSTDLPEGQDVYTAACNSVIHR 23 1 Q15751;H0YNB1 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 RVS(0.743)T(0.257)DLPEGQDVYTAACNSVIHR;RVS(0.723)T(0.277)DLPEGQDVYTAACNSVIHR 109.14 8.8165e-06 21339000.0 1615.47 2312.9 2097.23 2423.7 2202.9 1879.0 2170.83 1991.29 1069.47 1480.02 True False 1653.1073078425763 2042.1045927619605 1812.4376852597784 2000.4462934837381 2003.6480839535843 1860.098965995496 2007.0825453547395 1938.4745205784948 1814.8124790016896 1669.9949836156186 0.9898875889216867 1.2228207945515541 1.0852952871365904 1.1978756302325393 1.1997928757939087 1.1138350619283257 1.201849445684747 1.160766672712756 1.0867173235889214 1.0 10.705628053754385 -8.55593881419684 3.0224098526902163 1.000350074663367 1.150983445940104 0.3174626640509679 0.06645212076602035 0.2853705203935785 6.743836627616937 0.059564359122253586 0.015871059751663107 2.7801049166918065e-09 8.55593881419684 0.15063337127673715 RVS(ph)TDLPEGQDVYTAACNSVIHR ddPTM_A459_Selumetinib_30min_R2 2 RVSTDLPEGQDVYTAACNSVIHR 23 1 Q15751;H0YNB1 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 RVS(0.765)T(0.235)DLPEGQDVYTAACNSVIHR;RVS(0.5)T(0.5)DLPEGQDVYTAACNSVIHR 120.83 5.4325e-06 20768000.0 68369.0 50349.0 67118.0 79319.0 69960.0 65603.0 56166.0 51967.0 48158.0 58477.0 True False 64569.3246827919 54210.60640244843 62799.70095255301 68515.61536709305 61170.999349664664 74639.21776525912 58777.830290817605 52118.21536640005 57790.94564694629 56788.61706850741 1.137011746648068 0.9546033906240581 1.105850154385589 1.2065026215454178 1.0771700827979405 1.3143341327579345 1.0350283793653663 0.9177581363449442 1.0176501670612916 1.0 15.793314158847014 -7.5148179074944395 24.57499487645861 0.9759011066393284 1.1283293823044749 0.38185346026868516 0.08932629034978305 339.0865791214522 1033781.4859495378 0.041364792274072776 0.025312285749684454 3.056202259761051e-08 7.5148179074944395 0.1524282756651465 RVS(ph)VCAETYNPDEEEEDTDPR ddPTM_A459_Selumetinib_30min_R1 4 RVSVCAETYNPDEEEEDTDPR 21 1 P13861;P13861-2 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 RVS(0.96)VCAET(0.039)YNPDEEEEDTDPR;RVS(1)VCAETYNPDEEEEDTDPR;RVS(1)VCAETYNPDEEEEDTDPR;RVS(0.984)VCAET(0.016)YNPDEEEEDTDPR 150.34 9.4136e-07 347381400.0 6225.3 5383.27 6632.610000000001 6223.1900000000005 6652.7 5478.86 6472.599999999999 6356.9 3595.2299999999996 5206.02 True False 6370.337377674849 4752.994245785677 5731.937992318851 5136.426690244287 6050.96445962958 5423.747642806859 5984.366570879842 6188.2943618786985 6100.842724790075 5874.263377929068 1.0844487160057623 0.8091217468463787 0.9757713646029278 0.8743950279013706 1.0300805514380609 0.92330685464072 1.0187433190967323 1.0534587851694759 1.0385715335325816 1.0 12.520192236316301 -7.3593818116106595 4.845457816401292 1.0345775152510064 0.944674103148053 0.21415228485935744 0.072952016136215 0.31809032899406925 12.097994824336235 0.02965441012492623 0.019636610559347987 4.37137625003935e-08 7.3593818116106595 -0.08990341210295338 RVS(ph)VCAETYNPDEEEEDTDPR ddPTM_A459_Selumetinib_30min_R2 4 RVSVCAETYNPDEEEEDTDPR 21 1 P13861;P13861-2 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 RVS(0.999)VCAET(0.001)YNPDEEEEDTDPR;RVS(1)VCAETYNPDEEEEDTDPR;RVS(1)VCAETYNPDEEEEDTDPR;RVS(1)VCAETYNPDEEEEDTDPR 124.1 3.6694e-05 737710000.0 301176.5 255546.7 288738.2 382214.0 377656.0 299546.9 272760.4 301612.2 229784.7 281278.4 True False 284438.3158350548 275146.3101778502 270161.09856638213 330155.7938440741 330211.476992523 340806.7664589775 285444.2990644792 302489.84156741266 275748.0607209569 273157.1617429502 1.0412991335102555 1.0072820658342168 0.9890317238711557 1.208666072444996 1.2088699226684116 1.247658177015647 1.0449819336353026 1.1073838944485206 1.009485012076838 1.0 18.05937172312013 -5.74291955208511 24.999965382381248 1.1287512158612758 1.012012042016539 0.2535805655291721 0.08162575589039216 327.94727741998577 442693.4402059871 0.0233284207387618 0.04030992047307541 1.807508914645017e-06 5.74291955208511 -0.11673917384473675 RVS(ph)VELTNSLFK ddPTM_A459_Selumetinib_30min_R1 2 RVSVELTNSLFK 12 1 P14923 P14923 JUP Junction plakoglobin 1 RVS(1)VELTNSLFK;RVS(1)VELTNSLFK 160.79 0.00024439 27658000.0 10110.0 11925.099999999999 9755.6 8963.5 10318.3 8284.3 9447.4 10840.0 5177.8 9030.5 True False 10345.54332936448 10528.903748171415 8430.843103674995 7398.192990733791 9385.01158684383 8200.967463542576 8734.77501185462 10552.487986717595 8786.348428450488 10189.652639518947 1.0152989209112915 1.0332936872977139 0.8273925914782719 0.7260495771996266 0.9210335149645391 0.8048328783786435 0.8572200958036768 1.0356082155137898 0.8622814475906699 1.0 13.314817251093897 -9.89673363272342 9.623278818669167 1.000000173855092 0.8957195102367917 0.08680025227022548 0.09886995557312607 0.0 0.0 0.10195123629440504 0.02472680681789041 1.2684295974657104e-10 9.89673363272342 -0.10428066361830035 RVS(ph)VELTNSLFK ddPTM_A459_Selumetinib_30min_R2 1 RVSVELTNSLFK 12 1 P14923 P14923 JUP Junction plakoglobin 1 RVS(1)VELTNSLFK 81.44800000000002 0.044839 0.0 36257.0 26027.0 27667.0 33509.0 31585.0 23719.0 33650.0 34556.0 26934.0 32534.0 True False 34241.981088270775 28023.187210004664 25886.935341551947 28945.016393750793 27617.00992651738 26986.076950355677 35214.79167621004 34656.55223894622 32321.55259883823 31594.658886516405 1.0837901814753936 0.8869596380407218 0.8193453024618559 0.9161363791809636 0.8741037536032219 0.8541341448656208 1.1145805309276056 1.096911739526219 1.0230068542576365 1.0 14.947393069305656 -7.261019177388057 24.9999997597814 1.0667007628656011 0.8999978739767194 0.5118788224500455 0.07283695316557542 29.999783244251734 1784916.1615769016 0.029383141810407565 0.021330817666475536 5.482527548780997e-08 7.261019177388057 -0.16670288888888174 RVSEVEEEKEPVPQPLPS(ph)DDTR ddPTM_A459_Selumetinib_30min_R1 1 RVSEVEEEKEPVPQPLPSDDTR 22 2 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 RVS(0.16)EVEEEKEPVPQPLPS(0.839)DDT(0.001)R 59.154 0.020067 22192000.0 1610.8 1867.9 1483.1 1350.6 1639.9 1700.1 2142.5 1907.8 1292.5 1614.1 True False 1648.3285059288141 1649.2053996368484 1281.7031660851585 1114.743063901943 1491.5713345478612 1682.9985375672932 1980.8895000633536 1857.1989465922356 2193.278099534989 1821.2854576654165 0.9050357806302894 0.9055172503001556 0.7037354637027013 0.6120638910337852 0.8189662571949629 0.9240718035077357 1.0876326342618048 1.0197187589543784 1.2042473025323581 1.0 10.830741344309516 -7.001182799097791 2.3010537600604617 1.08185334130877 0.7793785761609399 0.6676453479616811 0.09602835712792711 0.19808532506083099 2.104509064364935 0.044328986058866336 0.03497401161699077 9.972802097788844e-08 7.001182799097791 -0.3024747651478302 RVSPLNLS(ph)SVTP ddPTM_A459_Selumetinib_30min_R1 1 RVSPLNLSSVTP 12 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 RVS(0.451)PLNLS(0.548)S(0.001)VTP 99.752 0.02528 40404000.0 3998.9 4636.9 4919.3 5719.0 5591.0 3870.9 4490.0 4316.3 2503.1 3827.1 True False 4092.0665894951194 4094.009592363675 4251.286079780676 4720.284008925815 5085.2950371712195 3831.9622604959927 4151.3156850802625 4201.817702681657 4247.577880809306 4318.345564110843 0.9476005402401567 0.9480504817373597 0.9844710240682245 1.0930769524688866 1.1776026169453377 0.8873681375438981 0.9613208631521427 0.9730156237616477 0.9836123158161133 1.0 12.076262980472986 -10.252284919032135 14.96737293543139 0.9999961863827581 0.9968606284376117 0.0 0.07802789177908302 0.0 0.0 0.08146464981285136 0.019758079760725897 5.593904927777693e-11 10.252284919032135 -0.0031355579451464166 RVSPLNLS(ph)SVTP ddPTM_A459_Selumetinib_30min_R2 1 RVSPLNLSSVTP 12 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 RVS(0.003)PLNLS(0.996)S(0.001)VTP 137.4 0.0023838 8312200.0 63571.0 41250.0 55909.0 57093.0 60480.0 43335.0 48523.0 52566.0 36846.0 47173.0 True False 60037.978314876076 44413.74236034474 52311.875809116595 49316.834909081546 52881.96170193991 49304.00289403698 50779.41564650043 52718.95835723024 44216.22956325811 45810.992919826596 1.3105583286515532 0.9694996665554232 1.1419066140012974 1.0765283999713888 1.1543509173548836 1.076248292201906 1.1084548142269919 1.1507927463937142 0.9651881949086004 1.0 15.483406212105997 -8.181809373403082 0.016596990746026594 4.4304258810647685e-07 2.139736446038556 0.22634757570676867 0.08698461720589512 668.0519029416639 10.205147333499138 662.4173844490348 650.3904805497355 6.5794656907699665e-09 8.181809373403082 2.139736002995968 RVSS(ph)VPSR ddPTM_A459_Selumetinib_30min_R2 2 RVSSVPSR 8 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 RVS(0.075)S(0.805)VPS(0.119)R;RVS(0.233)S(0.766)VPS(0.001)R 72.096 0.034332 6426500.0 18377.3 17241.0 12525.1 19376.4 15872.8 8336.9 13229.4 15732.3 10888.8 14072.6 True False 17355.96323616069 18563.329261447358 11719.248702297777 16737.300893845615 13878.716959367575 9485.23230015685 13844.593313558786 15778.07838837753 13066.864258492235 13666.287472994134 1.269983766290421 1.3583300730450927 0.8575297955246522 1.224714533988846 1.0155440522375387 0.6940606451386712 1.0130471308259101 1.1545255739392641 0.9561385478180219 1.0 13.738333759162401 -5.250928080948945 24.7321557045712 0.9945918841265691 1.3141569660913284 0.46502833520545517 0.13922296007475202 560.3619189650115 1318474.0621523687 0.036777825772728256 0.0950488815586983 5.6114089312185596e-06 5.250928080948945 0.3195650819647593 RVSSDEEHT(ph)VDSCISDMK ddPTM_A459_Selumetinib_30min_R2 1 RVSSDEEHTVDSCISDMK 18 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;H7C150;H7C183 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 RVS(0.048)S(0.048)DEEHT(0.904)VDS(0.001)CISDMK 64.327 0.044338 4637900.0 21210.0 17556.0 20511.0 21744.0 23027.0 15319.0 15608.0 17127.0 15114.0 22911.0 True False 20031.23311035725 18902.488748562722 19191.34459068826 18782.429689507804 20134.142396008097 17429.053197963585 16333.802926665272 17176.836734472512 18137.2223204441 22249.499900073093 0.9003003753037813 0.8495691513722798 0.8625517282132356 0.8441731173223403 0.9049256156962859 0.7833458404117356 0.7341200026977511 0.7720100142303011 0.8151743815322571 1.0 14.441485288671501 -6.770955941829159 24.987508435271398 0.8012550395782444 0.8689363328305945 0.08643139054203808 0.06977423487028643 339.2582818794568 890780.6254499753 0.023182298895894675 0.02070805449389019 1.6945096958179085e-07 6.770955941829159 0.06768129325235006 RVT(ph)AYTVDVTGR ddPTM_A459_Selumetinib_30min_R2 1 RVTAYTVDVTGR 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 RVT(0.999)AYT(0.001)VDVTGR 123.1 0.039832 0.0 18568.0 18416.0 20479.0 20690.0 16985.0 14872.0 18608.0 15695.0 11918.0 16137.0 True False 17536.064893593277 19828.447983226873 19161.403435849308 17871.98630775923 14851.192452173435 16920.483005425587 19473.30887105249 15740.669851552875 14301.933016742938 15671.082881038777 1.1190078584046692 1.265288948680011 1.2227236357120952 1.1404436083599199 0.9476813162760201 1.0797264703320868 1.2426268828310656 1.0044404698157965 0.9126320832651302 1.0 13.93581725387982 -6.409318874603739 0.3756778538699901 0.976004600999177 1.2542039276653516 0.365401081390909 0.09497574638236062 2.3711670369057236 0.6077762153867795 0.10940280683453577 0.26530161172649197 3.896557823510629e-07 6.409318874603739 0.27819932666617464 RVTIMPK ddPTM_A459_Selumetinib_30min_R1 1 RVTIMPK 7 1 K7EK07;Q5TEC6;Q6NXT2;Q71DI3;Q16695;P84243;P68431;A0A590UJL8 K7EK07 H3F3B;HIST2H3PS2;H3F3C;HIST2H3A;HIST3H3;H3F3A;HIST1H3A Histone H3;Histone H3.3C;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1 0 98.523 0.029498000000000007 16686000.0 10363.0 5399.6 7104.1 7277.7 7394.8 11152.0 5385.2 6884.4 6367.5 7608.6 False True 10604.437737112175 4767.4123217940605 6139.402240028034 6006.78631434856 6725.941645657975 11039.821005205842 4978.990028350604 6701.803348317209 10805.182436200408 8585.237924040071 1.2351943919245398 0.5553034597264365 0.7151114848939366 0.6996645133769183 0.7834310132307734 1.2859074032523357 0.5799478211790283 0.7806194082928165 1.2585769354095742 1.0 13.067642401076611 -6.571355393276368 24.999761561098452 0.9525033697346511 0.773080267281467 0.10658978157287102 0.2540006684046698 276.5300091259866 142606.66200132947 0.08292355603896029 0.08292357684908179 2.6831478647158824e-07 6.571355393276368 -0.17942310245318416 RVTNDIS(ph)PESSPGVGR ddPTM_A459_Selumetinib_30min_R1 1 RVTNDISPESSPGVGR 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 RVTNDIS(0.967)PES(0.033)SPGVGR 191.15 1.8801e-06 11083000.0 1629.7 1562.3 2613.8 2494.7 1981.1 1928.3 1980.2 1654.2 1061.8 1385.0 True False 1667.6688391558152 1379.3851897064337 2258.8603165756795 2059.047476318803 1801.9098547916137 1908.903052756316 1830.8319197318333 1610.3252424011284 1801.7970491963245 1562.778241042439 1.067118030798413 0.8826493442769753 1.4454132117100147 1.3175557620672602 1.1530169844121094 1.2214804395299215 1.1715238103843775 1.0304246630199903 1.1529448016850106 1.0 10.60989735842742 -7.687663120818719 6.6646727558283 1.069175225862478 1.1852177146181495 0.1241860539354338 0.14368975939289008 0.506762482864561 36.47304573771157 0.07373489449447927 0.04188188220791274 2.0527538681818064e-08 7.687663120818719 0.11604248875567147 RVTNDIS(ph)PESSPGVGR ddPTM_A459_Selumetinib_30min_R2 2 RVTNDISPESSPGVGR 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 RVT(0.001)NDIS(0.999)PESSPGVGR;RVT(0.007)NDIS(0.851)PES(0.142)SPGVGR 166.9 2.8085e-05 10563500.0 46062.0 42228.0 44586.0 57084.0 46430.0 27831.6 32596.2 26708.1 22617.3 44798.0 True False 43502.05844079566 45466.751815579104 41717.38530156634 49309.06072460744 40597.048310533566 31665.150269889902 34111.98788814494 26785.81614923603 27141.391980162767 43504.565340817695 0.9999423761620788 1.0451030014755809 0.9589197127876014 1.1334226727314005 0.9331675421302007 0.7278580999907247 0.7841013378919967 0.61570127041597 0.623874569658041 1.0 15.408879183935174 -6.652472638474926 3.471525039341051 0.7267452693195959 1.0306412593641283 0.6006652167345827 0.10891799792713439 0.15084191209281772 3.544219116969486 0.036631271935729924 0.03622050393225644 2.226011284071886e-07 6.652472638474926 0.3038959900445324 RVTNDISPES(ph)SPGVGR ddPTM_A459_Selumetinib_30min_R1 1 RVTNDISPESSPGVGR 16 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 RVTNDIS(0.091)PES(0.819)S(0.091)PGVGR 212.35 5.3879e-08 8904500.0 1245.0 1188.7 1805.1 1917.6 1655.7 1265.7 1363.2 1552.0 843.55 992.11 True False 1274.0060776517093 1049.5264513883621 1559.9773347045523 1582.727157810133 1505.9422273375778 1252.9682071636514 1260.3727264813833 1510.8359183935142 1431.4427395456396 1119.4569824697583 1.138057198804534 0.9375317388908374 1.3935125325342232 1.4138347275464778 1.345243498338946 1.119264274362146 1.1258786592234524 1.3496149848119143 1.2786938327791524 1.0 10.128583375273363 -11.786921636699734 2.1365289707881034 0.13859601917671896 1.234993378924467 0.19121508265046439 0.1440467948773851 2276587.8045461103 416825.5243305753 9452757.21315428 0.04068614313057677 1.633346639380473e-12 11.786921636699734 1.0963973597477479 RVTQHES(ph)DNENEIQIQNK ddPTM_A459_Selumetinib_30min_R2 1 RVTQHESDNENEIQIQNK 18 1 Q5VZL5-2;Q5VZL5-4;Q5VZL5 Q5VZL5-2 ZMYM4 Zinc finger MYM-type protein 4 1 RVT(0.108)QHES(0.892)DNENEIQIQNK 72.615 0.013373 10531000.0 72084.0 83435.0 94302.0 98711.0 100020.0 51805.0 47009.0 62135.0 36437.0 91375.0 True False 68077.85985511518 89834.1962141905 88234.71198825416 85266.39151402692 87454.59340985485 58940.668511032316 49195.01164656634 62315.80256299703 43725.418134843305 88736.76632923813 0.7671888741418337 1.0123672512572814 0.9943422060353065 0.9608913536207173 0.9855508266480427 0.6642192514920592 0.5543926568615216 0.7022546024698267 0.4927542431804402 1.0 16.437244360183655 -6.766491930717441 24.65177583546118 0.656094271985322 0.9515901474712919 0.4570985943654874 0.14080355134874875 82.51768229098586 402606.8346306323 0.04582922334405359 0.04166755508362531 1.7120169860420103e-07 6.766491930717441 0.2954958754859699 RVVLGDGVQLPPGDY(ph)STTPGGTLFS(ph)TTPGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.281)S(0.259)T(0.226)T(0.226)PGGT(0.132)LFS(0.614)T(0.115)T(0.115)PGGT(0.031)R 60.348 0.0043426 195000000.0 1462.2 1378.9 1814.4 1995.4 2131.8 1692.4 1382.8 1357.3 967.54 1313.2 True False 1496.2664150540793 1217.457746966781 1568.014445785795 1646.9408482970057 1938.9790663998601 1675.3759925762533 1278.4942827013326 1321.2999948682466 1641.8447136743375 1481.7620116512132 1.009788618744992 0.8216283974037757 1.0582093706387206 1.1114746061425371 1.3085630831088344 1.1306646947368322 0.8628202590216444 0.8917086444913279 1.1080353665193068 1.0 10.533098037176487 -10.776636855739163 13.829024691385277 0.9999987619375954 1.032169064078388 0.005177375595076694 0.13858376864982172 1.0287195726497901e-10 0.0 0.1487956153122582 0.03608823756242431 1.6724885154486174e-11 10.776636855739163 0.03217030214079264 RVVLGDGVQLPPGDYST(ph)T(ph)PGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.009)S(0.068)T(0.608)T(0.608)PGGT(0.13)LFS(0.374)T(0.091)T(0.094)PGGT(0.018)R 71.117 0.00029551 63194000.0 1647.1 2029.8 1871.6 2151.8 2377.6 1863.0 1759.8 1524.3 1250.7 1897.9 True False 1685.4742253013087 1792.1500723715799 1617.446999962905 1776.028524288613 2162.5464997993736 1844.25991146866 1627.0568691768922 1483.870612375795 2122.346552486197 2141.5139521115125 0.787047977735306 0.8368612637823521 0.7552820276366248 0.8293331558907032 1.009821345159635 0.8611944412737714 0.7597694460839863 0.6929072822115927 0.9910496031994485 1.0 11.064415361179634 -8.359130965731772 9.367792421960331 0.9980948270391808 0.8216943041569977 0.4465025495161816 0.07956103131053391 0.44716202260362214 39.78282316081844 0.08308759163160047 0.021467101198534583 4.373901859969986e-09 8.359130965731772 -0.1764005228821831 RVVLGDGVQLPPGDYST(ph)TPGGT(ph)LFSTTPGGTR ddPTM_A459_Selumetinib_30min_R2 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.014)S(0.113)T(0.438)T(0.438)PGGT(0.252)LFS(0.244)T(0.244)T(0.249)PGGT(0.01)R 71.903 0.0002336 59070000.0 166800.0 153820.0 185510.0 179200.0 195280.0 137830.0 126470.0 129140.0 130730.0 197680.0 True False 157529.92375330473 165617.4993907448 173574.48856801612 154792.65086275735 170747.1805746499 156814.83140383346 132351.1055955507 129515.77601972214 156879.6529013931 191972.4647656783 0.8205860353232732 0.8627148669101978 0.9041634631293672 0.8063273608102982 0.8894357885286517 0.8168610617946784 0.6894275476282421 0.6746580879596934 0.817198722185916 1.0 17.550539869785283 -7.004612519630257 23.433040541391833 0.7660571252161869 0.8564592759145281 0.06050003765600731 0.08875414266816146 146.73524292845954 745468.3344846112 0.030381043684907096 0.026068535860497465 9.894354817537475e-08 7.004612519630257 0.09040215069834123 RVVLGDGVQLPPGDYST(ph)TPGGTLFS(ph)TTPGGTR ddPTM_A459_Selumetinib_30min_R1 2 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.028)S(0.043)T(0.464)T(0.464)PGGT(0.106)LFS(0.287)T(0.287)T(0.286)PGGT(0.034)R;RVVLGDGVQLPPGDY(0.005)S(0.024)T(0.481)T(0.481)PGGT(0.074)LFS(0.269)T(0.269)T(0.268)PGGT(0.13)R 80.418 1.154e-05 69128000.0 7727.299999999999 9149.3 10046.8 10902.5 9695.9 8731.6 8867.8 8735.8 4818.6 7653.799999999999 True False 7907.331055291611 8078.095702605823 8682.49974312209 8998.583040271675 8818.907556950177 8643.768031658474 8198.894706493258 8504.098206122466 8176.812263380495 8636.239784325358 0.9155988315242584 0.935371863720996 1.0053564930979213 1.04195613658203 1.021151308577184 1.00087170429737 0.9493593173934477 0.984699176782617 0.9468023662591308 1.0 13.076187584860694 -3.077701212537815 8.486411381154156 0.981731234386836 0.9360199113553156 0.0 0.039036778562870106 0.0 0.0 0.009788260096200721 0.0 0.0008361780971672123 3.077701212537815 -0.04571132303152037 RVVLGDGVQLPPGDYST(ph)TPGGTLFS(ph)TTPGGTR ddPTM_A459_Selumetinib_30min_R2 3 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.002)S(0.02)T(0.478)T(0.478)PGGT(0.113)LFS(0.291)T(0.29)T(0.288)PGGT(0.039)R;RVVLGDGVQLPPGDY(0.023)S(0.11)T(0.401)T(0.401)PGGT(0.151)LFS(0.303)T(0.303)T(0.303)PGGT(0.006)R;RVVLGDGVQLPPGDY(0.088)S(0.098)T(0.383)T(0.383)PGGT(0.103)LFS(0.31)T(0.308)T(0.305)PGGT(0.022)R 72.514 9.3676e-05 72238000.0 244100.3 256910.4 241570.0 299148.8 285804.4 195897.9 167204.0 195225.0 161475.2 295235.7 True False 230534.18253692312 276614.6015828639 226027.64920152872 258404.2173795358 249899.09614824585 222881.05754091998 174979.31730844054 195793.07242876128 193774.7519940572 286711.47822652885 0.8040633181584017 0.9647838422580086 0.7883453100644466 0.9012691747742737 0.8716047843428236 0.7773705430963707 0.6102975660088171 0.682892340550337 0.6758527882896863 1.0 18.12924013712133 -6.916617492015142 4.08839814097975 0.71311797986822 0.868631370630222 0.21142717520936205 0.10793313030444185 0.26090674084042326 8.321448515108695 0.0372278704421517 0.032348523144184925 1.211664846241881e-07 6.916617492015142 0.155513390762002 RVVLGDGVQLPPGDYST(ph)TPGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.003)S(0.061)T(0.782)T(0.151)PGGT(0.014)LFS(0.256)T(0.22)T(0.471)PGGT(0.042)R 94.46 3.8536e-08 99455000.0 830.24 1152.0 1125.3 1278.5 1148.5 860.31 946.09 718.19 436.95 724.21 True False 849.5829766341807 1017.1233044497295 972.4904408304429 1055.233975417321 1044.6183777841445 851.6560624989816 874.7256695985707 699.1412681901018 741.4722364346713 817.1694079027762 1.0396656659169268 1.2446908739035212 1.1900720112935825 1.2913282915540432 1.2783375976654638 1.0422025766783336 1.0704336960478118 0.8555646619033528 0.9073666112117709 1.0 9.67449138516613 -7.229355114939497 1.7040458809692103 0.9202308169115361 1.210656430475285 0.6635155043728083 0.08436520935153019 0.2143889921289424 1.2174392162662337 0.04527968044524212 0.028522899252360952 5.8971868040797035e-08 7.229355114939497 0.29042561356374885 RVVLGDGVQLPPGDYST(ph)TPGGTLFSTTPGGT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.051)S(0.126)T(0.352)T(0.352)PGGT(0.149)LFS(0.231)T(0.231)T(0.231)PGGT(0.278)R 48.226000000000006 0.044249 46469000.0 2311.9 2645.4 1630.6 2246.0 2008.0 1918.3 2321.4 2260.7 1396.7 1935.0 True False 2365.762771825692 2335.675338186904 1409.1734762446636 1853.7782626416135 1826.3767545411938 1899.003643677041 2146.2949290301385 2200.738892211483 2370.0978890681004 2183.376098496114 1.0835342447209182 1.0697540106790084 0.6454103245040042 0.8490421159773966 0.8364920527430809 0.8697556252379305 0.9830165909155474 1.0079522688405942 1.08551975571254 1.0 11.09234494852264 -7.476360070280476 2.6166410757646474 1.0353693502963106 0.8847201986615095 0.2213130524138187 0.11815826437316689 0.46640297634115213 6.322845798092074 0.06670283860903116 0.037991806327670435 3.33918076268321e-08 7.476360070280476 -0.15064915163480108 RVVLGDGVQLPPGDYST(ph)TPGGTLFSTTPGGT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.05)S(0.057)T(0.324)T(0.378)PGGT(0.214)LFS(0.185)T(0.185)T(0.185)PGGT(0.422)R 45.983 0.026178 0.0 12330.0 11813.0 12540.0 16515.0 13876.0 10383.0 7923.2 8962.6 7245.9 15513.0 True False 11644.74796090075 12719.019115218241 11733.190052519665 14265.628510035938 12132.772826986073 11813.164002510346 8291.64449952295 8988.679682161694 8695.282467361776 15065.099382385482 0.7729619078727155 0.8442705084368484 0.7788325688868953 0.9469322536773765 0.8053563085798183 0.7841411266309078 0.550387640271246 0.5966558503206092 0.5771805579675454 1.0 13.878922569773678 -7.076797926612023 5.3710453131070155 0.6478443475164763 0.8309687974510153 0.21734317087629873 0.1271378601306744 0.2643249815825696 13.454157710874103 0.04636763619871285 0.036067646403858164 8.37919067782062e-08 7.076797926612023 0.1831244499345389 RVVLGDGVQLPPGDYST(ph)TPGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 RVVLGDGVQLPPGDY(0.089)S(0.234)T(0.295)T(0.295)PGGT(0.076)LFS(0.003)T(0.005)T(0.003)PGGT(0.001)R 54.08600000000001 0.002615 8615900.0 794.56 606.09 1119.4 1230.6 917.04 869.22 720.14 823.96 734.01 728.63 True False 813.0717020553747 535.1287010364031 967.3916284240629 1015.698811222961 834.0938939165623 860.4764359886141 665.8192600119594 802.1059042007224 1245.5613600306983 822.1567579572215 0.9889497278786346 0.6508840265036743 1.1766510693504488 1.2354077265588927 1.0145192943362777 1.0466087247480684 0.8098446598751954 0.9756118847623187 1.5149925460997151 1.0 9.68326968388377 -5.271971248401087 24.992447648779294 1.0858178598066082 0.8199168684010267 0.24527863953006634 0.19345673205888117 916.6220062237954 2175174.1114122323 0.051290674376347115 0.1085847010832687 5.345997503343712e-06 5.271971248401087 -0.26590099140558143 RVVLGDGVQLPPGDYSTT(ph)PGGTLFS(ph)TTPGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.027)S(0.043)T(0.098)T(0.836)PGGT(0.045)LFS(0.531)T(0.128)T(0.289)PGGT(0.002)R 104.6 1.8277e-11 283590000.0 2211.7 2418.0 2715.9 2962.8 2675.2 2145.7 2265.7 2066.0 1390.3 1876.4 True False 2263.228306780951 2134.8994359022972 2347.095697370834 2445.402598644067 2433.2286323449202 2124.116206139722 2094.7964248744643 2011.2029686862131 2359.2375565056054 2117.254217683779 1.0689449986109194 1.0083340101869398 1.108556392410211 1.154987709184622 1.1492378251142694 1.0032409846671364 0.9893929634798966 0.9499109515939076 1.1142911119509067 1.0 11.047978788099488 -6.7827091299183255 24.850860333633797 1.0068632056747622 1.0967811599588342 0.3832654943422589 0.05479586115001714 251.52246154303333 293868.3040603566 0.02051771432319742 0.018112049671585553 1.6492666231597224e-07 6.7827091299183255 0.08991795428407201 RVVLGDGVQLPPGDYSTT(ph)PGGTLFS(ph)TTPGGTR ddPTM_A459_Selumetinib_30min_R2 2 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 RVVLGDGVQLPPGDY(0.006)S(0.026)T(0.104)T(0.861)PGGT(0.022)LFS(0.324)T(0.324)T(0.324)PGGT(0.01)R;RVVLGDGVQLPPGDY(0.122)S(0.132)T(0.157)T(0.563)PGGT(0.099)LFS(0.282)T(0.282)T(0.282)PGGT(0.08)R 80.608 1.0994e-05 25431300.0 51656.5 58252.7 60427.0 66779.0 64947.0 46207.0 45846.7 45904.8 38422.2 63060.0 True False 48785.63852735356 62720.49477804738 56539.19260794302 57683.584999799525 56787.77722645324 52571.59482461675 47978.6623935126 46038.37536805126 46107.71360596579 61239.2939504434 0.7966394675750558 1.0241870983816797 0.9232502362567433 0.941937460064101 0.9273094701648184 0.8584618050488825 0.7834620437057669 0.751778350111398 0.7529106008844171 1.0 15.90217002913983 -6.943138853748579 2.9924486235962062 0.8020934339352082 0.9297649185896082 0.22599673987107827 0.08452220121502582 0.3007450569998677 5.480605187384418 0.03127859933577428 0.026258728742747647 1.1398852822402362e-07 6.943138853748579 0.12767148465440004 RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 RVVLGDGVQLPPGDY(0.006)S(0.016)T(0.038)T(0.845)PGGT(0.045)LFS(0.008)T(0.009)T(0.009)PGGT(0.025)R 80.439 8.798299999999999e-05 0.0 732.72 636.09 780.7 968.68 996.12 639.23 585.69 792.02 426.2 415.99 True False 749.7909503750689 561.616287089782 674.6852280781364 799.5182223756354 906.0211218792697 632.7999265744021 541.510931758276 771.0130567564635 723.2302715836071 469.3863685857359 1.5973854388532707 1.1964904067877713 1.4373771230531627 1.7033264617048613 1.9302246134865761 1.3481429562623053 1.1536571319483602 1.6425978860006751 1.5407994777579597 1.0 8.874632135045873 RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R2 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 RVVLGDGVQLPPGDY(0.03)S(0.05)T(0.255)T(0.59)PGGT(0.059)LFS(0.005)T(0.005)T(0.005)PGGT(0.001)R 61.597 0.0073781 0.0 4582.5 5355.3 4975.0 6808.2 5126.9 4612.1 3989.6 3802.3 3153.1 4257.5 True False 4327.822995200949 5766.034289996462 4654.91391637044 5880.911415199917 4482.812986932466 5247.3749105247025 4175.124305242423 3813.364063495351 3783.8081049750085 4134.574912686532 1.0467395286324246 1.3945893862761947 1.1258506653458618 1.4223738931794234 1.0842258470580373 1.2691449595999953 1.0098073909439806 0.9223110341511583 0.915162546303072 1.0 12.013523294135037 -7.376934886446426 3.6886991096370982 0.94207024496183 1.2301454876569002 0.5489712166693583 0.11696542303387257 0.17115682141496494 4.194114704702565 0.04901489190638603 0.03160481864882677 4.198219229627655e-08 7.376934886446426 0.28807524269507023 RVVLGDGVQLPPGDYSTTPGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R1 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 RVVLGDGVQLPPGDY(0.074)S(0.018)T(0.032)T(0.085)PGGT(0.185)LFS(0.134)T(0.134)T(0.292)PGGT(0.048)R 65.77600000000001 0.00031007 43902000.0 1239.6 1108.8 1603.9 1880.6 1664.1 1342.8 1441.9 1337.3 797.46 866.13 True False 1268.4802681582794 978.9811805328642 1386.0991895920617 1552.188513234113 1513.582448820718 1329.2926511648498 1333.1363221196495 1301.8304598374013 1353.2313758260523 977.3062223206416 1.2979353238396831 1.0017138519882185 1.4182854441474133 1.5882314854686967 1.5487289595135014 1.3601598156291343 1.3640927394835154 1.3320599317849093 1.3846544152893712 1.0 9.932666866812998 -10.642997120912097 3.374641143940298 0.9996149014812132 1.3676722989190142 0.34970678865244564 0.14980129329041142 53351394.03247794 83753508.40625861 230542.31678131336 0.04106401494436192 2.275112513227581e-11 10.642997120912097 0.36805739743780097 RVVLGDGVQLPPGDYSTTPGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R2 1 RVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 32 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 RVVLGDGVQLPPGDY(0.001)S(0.003)T(0.003)T(0.04)PGGT(0.222)LFS(0.159)T(0.159)T(0.378)PGGT(0.036)R 89.20299999999997 2.3929e-07 15785000.0 19182.0 22797.0 24178.0 27335.0 28086.0 14506.0 10146.0 14699.0 12272.0 22620.0 True False 18115.94123163003 24545.456596091608 22622.413803015985 23611.92584449484 24557.585587974256 16504.069827642787 10617.809103917596 14741.77165644956 14726.742908329357 21966.90182618189 0.8246925932011959 1.1173836342654564 1.029840893450564 1.0748864829155051 1.1179357827649863 0.7513153178465947 0.4833548758005761 0.6710901597820751 0.6704060055832207 1.0 14.423043788446316 -6.863260580135386 5.202651804626925 0.6715694737496152 1.038884607525768 0.5477182933739069 0.1429743008153599 0.13974299398559778 5.946996723221966 0.048837930443442625 0.04316350569066366 1.370059472942735e-07 6.863260580135386 0.3673151337761529 RWDQTADQT(ph)PGATPK ddPTM_A459_Selumetinib_30min_R2 1 RWDQTADQTPGATPK 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 RWDQT(0.294)ADQT(0.423)PGAT(0.283)PK 144.15 0.047844 18561000.0 15620.0 14780.0 16943.0 15078.0 14835.0 11729.0 13362.0 11944.0 9510.0 13604.0 True False 14751.90293181425 15913.578474809572 15852.9058261436 13024.350388999203 12971.294673417302 13344.563284738884 13983.359476300693 11978.755062564356 11412.265731601383 13211.217172563142 1.116619516515918 1.2045505169545356 1.1999580068267046 0.9858554453292903 0.9818394856422384 1.0100934009663147 1.0584459625219942 0.9067109340569812 0.8638315139730052 1.0 13.689475770276974 -5.773448417129753 12.697075809220447 0.9740322717833804 1.176804918494361 0.7334909323879557 0.05559278777987632 0.3416622822892181 359.77086145895015 0.016775399129887562 0.025626302541630796 1.684812526726066e-06 5.773448417129753 0.2027726467109806 RWDQTADQTPGAT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 RWDQTADQTPGATPK 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 RWDQTADQTPGAT(1)PK 132.5 0.00077208 60244000.0 7533.7 9286.5 10501.0 11385.0 7237.0 9301.9 8735.9 8002.4 5294.6 7239.4 True False 7709.220551971637 8199.232262823274 9075.021877864112 9396.823472918415 6582.414627796127 9208.331331449448 8076.944029686561 7790.150356541408 8984.54949771601 8168.647507727536 0.9437572798530869 1.0037441638982223 1.1109577037421612 1.1503524254203679 0.8058145025316819 1.1272773519408654 0.9887737256437833 0.9536646487894024 1.0998821395116671 1.0 12.9958815141445 RWS(ph)AEVTSSTYSDEDRPPK ddPTM_A459_Selumetinib_30min_R2 4 RWSAEVTSSTYSDEDRPPK 19 2 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 RWS(0.634)AEVT(0.338)S(0.027)S(0.001)TYSDEDRPPK;RWS(0.974)AEVT(0.024)S(0.002)STYSDEDRPPK;RWS(0.893)AEVT(0.096)S(0.011)S(0.001)TYSDEDRPPK;RWS(0.83)AEVT(0.141)S(0.018)S(0.007)T(0.002)Y(0.001)S(0.001)DEDRPPK 104.81 0.0010058 62479000.0 71612.6 66216.5 68283.8 74683.9 81033.0 68981.5 73424.8 75384.8 69102.0 64776.1 True False 67632.6583799515 71295.09263039439 63890.494649780165 64511.82398308641 70852.91009578864 78483.07547328976 76839.19868848102 75604.15728737458 82924.33087120081 62905.845684480126 1.0751410722491497 1.133361961112368 1.0156527418809183 1.0255298737522975 1.1263326853782236 1.2476276984962749 1.2214953610811796 1.2018621872852004 1.3182293309770983 1.0 15.940906468961549 -6.557744625981312 4.559879509796396 1.2111863377043959 1.064820919866704 0.37456107782227277 0.08153787726199618 0.19237154638762094 9.333905554045348 0.025988060523015645 0.02663346072502156 2.768569142022051e-07 6.557744625981312 -0.14636541783769186 RWS(ph)APESR ddPTM_A459_Selumetinib_30min_R2 2 RWSAPESR 8 1 P54253 P54253 ATXN1 Ataxin-1 1 RWS(1)APESR;RWS(1)APESR 80.706 0.023358 13767100.0 57787.0 44524.0 57415.0 61140.0 53890.0 37398.0 36763.0 44369.0 30335.0 47336.0 True False 54575.4298796895 47938.847632775476 53720.98140872542 52812.62652761714 47119.85641728736 42549.23503475701 38472.55234450251 44498.106444316625 36402.847630718 45969.28668630174 1.1872150693161023 1.0428451491952482 1.1686276921223924 1.1488676534838342 1.0250290969019642 0.925601376525952 0.8369186280187993 0.9679964526744874 0.7918949858659778 1.0 15.488382659319146 -6.5903244999775685 2.4025501145830046 0.8952070840081322 1.1321337955868611 0.7329936364922024 0.0661064192099927 0.14429769316285562 1.6907295501957642 0.022620345472374223 0.023247928743627813 2.5684759291359663e-07 6.5903244999775685 0.2369267115787289 RWS(ph)GNEPTDEFSDLPLR ddPTM_A459_Selumetinib_30min_R1 1 RWSGNEPTDEFSDLPLR 17 1 Q96II8-3;Q96II8;Q96II8-2;E9PD99;Q96II8-4 Q96II8-3 LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 1 RWS(1)GNEPTDEFSDLPLR 155.16 2.704e-05 4357000.0 621.32 747.14 777.0 661.34 740.83 667.12 787.61 781.39 362.94 761.95 True False 635.7955471217354 659.6645014640376 671.4876677554913 545.8493838893162 673.8220573041597 660.409378496496 728.1999435915508 760.6649988875698 615.882671911202 859.7537045215068 0.7395089358476046 0.7672714848389885 0.7810232910007705 0.6348904122409184 0.7837384750545194 0.7681378690470949 0.8469866890504741 0.8847475676896507 0.7163477966680812 1.0 9.747779616849318 -7.109493509846066 1.9158816138604537 0.8552474379645421 0.7380304699854413 0.3693736481459159 0.07509392209704058 0.41170419219518045 2.9850093575954615 0.03464244706719813 0.024601682269391204 7.771529325826753e-08 7.109493509846066 -0.11721696797910075 RWS(ph)GNEPTDEFSDLPLR ddPTM_A459_Selumetinib_30min_R2 2 RWSGNEPTDEFSDLPLR 17 1 Q96II8-3;Q96II8;Q96II8-2;E9PD99;Q96II8-4 Q96II8-3 LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 1 RWS(1)GNEPTDEFSDLPLR;RWS(1)GNEPTDEFSDLPLR 155.08 2.8499e-05 7378900.0 13525.0 12940.3 14028.7 15828.4 13395.5 13029.6 12759.400000000001 13525.6 10753.0 14549.3 True False 12773.334644864768 13932.779400377425 13126.10871529367 13672.544614487007 11712.637532710585 14824.309129067591 13352.73738227145 13564.957256716381 12903.900463923206 14129.223905378774 0.9040365366424804 0.9860965820687033 0.9290042257945086 0.9676783881443116 0.8289653848752279 1.0491948622474734 0.945043936715326 0.9600638610838642 0.9132773710954424 1.0 13.786394602573639 RWS(ph)TELVPEGLQSPR ddPTM_A459_Selumetinib_30min_R1 1 RWSTELVPEGLQSPR 15 1 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 RWS(0.785)T(0.215)ELVPEGLQSPR 111.62 0.0016476 3110000.0 1428.7 1733.9 1576.4 1536.8 1404.6 1250.7 1199.7 1150.0 948.98 1465.4 True False 1461.9859302337325 1530.8941819317597 1362.3335385453747 1268.42672930883 1277.5541780022713 1238.119093544741 1109.2056631159887 1119.4982642735451 1610.349749243105 1653.4983642047575 0.8841774276183623 0.9258516458636088 0.8239098193487375 0.7671170149109123 0.7726370982028187 0.7487876131889666 0.6708235624106323 0.6770483046785248 0.9739046521631095 1.0 10.691305902942943 -5.447662811088433 3.567367762248422 0.7795964396810986 0.9042348154273216 0.10602285768312347 0.10529923766855186 0.3954085714743597 9.577678173828435 0.027820627780485076 0.06167039938334481 3.567279917457825e-06 5.447662811088433 0.12463837574622305 RWS(ph)TELVPEGLQSPR ddPTM_A459_Selumetinib_30min_R2 1 RWSTELVPEGLQSPR 15 1 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 RWS(0.781)T(0.219)ELVPEGLQSPR 66.60600000000001 0.032183 2268800.0 7463.9 6506.9 8648.9 9801.7 9992.4 7680.9 9757.4 6935.9 6983.7 7587.3 True False 7049.08631835905 7005.958307018842 8092.439190210316 8466.691551124391 8737.065378810586 8738.874254731934 10211.138433921298 6956.082320699946 8380.635140881664 7368.234934827132 0.9566858794146784 0.9508326443154069 1.0982873458553986 1.1490800206580316 1.1857745384194334 1.186020034924003 1.385832363414029 0.9440635894793363 1.1374006414031754 1.0 12.847103346892974 -5.367325690954784 2.7495079604601753 1.152323792751576 0.9478534204996428 0.3015491650256382 0.11130323428754614 0.3246721718255071 4.677731393048333 0.030939298029989258 0.08182495650542934 4.292144247785538e-06 5.367325690954784 -0.2044703722519331 RWS(ph)WGGSAMANSESK ddPTM_A459_Selumetinib_30min_R1 1 RWSWGGSAMANSESK 15 1 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 RWS(0.997)WGGS(0.003)AMANSESK 93.754 0.021813 10037000.0 1507.7 1639.6 1626.7 1845.6 1755.4 1395.2 1833.4 1455.5 808.06 1221.3 True False 1542.8264765264908 1447.6348697706387 1405.803074823497 1523.3006062027441 1596.6243799410418 1381.1655547402427 1695.1051619211914 1416.8954118696909 1371.2188016326832 1378.0657514694078 1.1195594077288413 1.0504831632504112 1.0201277212821762 1.105390366590618 1.1585981135069852 1.0022493870611977 1.230061163709881 1.0281769286834679 0.99503147812111 1.0 10.428429009464672 -7.983629791808909 24.99938470687069 1.002211806433513 1.094803388192104 0.31009783809616376 0.06265206088093163 278.81310275923886 425782.89207515324 0.033544254445586535 0.01610787653238749 1.0384132193131519e-08 7.983629791808909 0.09259158175859095 RY(ph)SDFEWLR ddPTM_A459_Selumetinib_30min_R1 1 RYSDFEWLR 9 1 O60493-4;O60493;O60493-3 O60493-4 SNX3 Sorting nexin-3 1 RY(0.986)S(0.014)DFEWLR 115.23 0.014005000000000002 3401600.0 518.0 656.84 753.04 909.33 671.55 631.38 770.1 713.63 421.66 574.32 True False 530.0683921474584 579.9368674433687 650.7813041526321 750.532585738156 610.8084210717823 625.0288904471723 712.0107369889329 694.70221420307 715.5262231720874 648.039566350537 0.817956834229369 0.8949096591575547 1.0042308185247626 1.158158582761872 0.9425480368607374 0.9644918657776557 1.0987149148911575 1.0720058624125617 1.1041397166558893 1.0 9.3399380899758 -5.1855252110292405 2.5698800118052034 1.0475355666511426 0.8284962107997321 0.5983074519324191 0.06313319888588145 0.2130734131364846 2.6289235433185376 0.01781282555992147 0.06706018231600416 6.523411711417175e-06 5.1855252110292405 -0.21903935585141043 RYCHDLGER ddPTM_A459_Selumetinib_30min_R1 1 RYCHDLGER 9 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 0 89.029 0.041147 1203700.0 728.19 881.03 762.35 1066.7 1074.7 967.16 797.07 942.54 554.38 605.41 False True 745.155410188914 777.8785980202651 658.8270572888009 880.4208694389181 977.4935747536963 957.4312485110189 736.9463681752616 917.5407773985977 940.7423696868134 683.1202706927824 1.090811445886709 1.1387139737946645 0.9644378677573942 1.288822638136685 1.430924562906583 1.401555903969949 1.0787944667897087 1.3431613974331038 1.3771255371074922 1.0 9.415995792677565 -5.7813609039090235 24.21101550208461 1.292316342326619 1.072060436368171 0.3231044006812962 0.13724172510682348 175.82350861109563 213681.05675687152 0.038160988425409104 0.05669680411731142 1.6543945703885541e-06 5.7813609039090235 -0.22025590595844813 RYDDPEVQK ddPTM_A459_Selumetinib_30min_R1 1 RYDDPEVQK 9 1 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 121.6 0.0050602 0.0 4749.1 6849.1 5838.5 7405.5 5487.8 6577.2 4909.0 5205.8 2513.5 4292.5 False True 4859.744789860026 6047.204187939793 5045.66376858486 6112.268443451676 4991.42945894978 6511.039339619791 4538.7101777414255 5067.725273178457 4265.2259212233585 4843.484187490736 1.0033572118210452 1.2485235739094398 1.0417425913387501 1.2619569315902441 1.03054521615682 1.3442883444186415 0.9370754609798355 1.0462974745054126 0.8806110964993248 1.0 12.241829516380365 -7.306612601074946 24.999019159817458 0.9698540561288962 1.1533642411820297 0.41042346124692974 0.11096705082340624 433.0420149041363 239645.31144105303 0.04237355754175136 0.02856833433816679 4.936139206203994e-08 7.306612601074946 0.18351018505313355 RYDDPEVQK ddPTM_A459_Selumetinib_30min_R2 2 RYDDPEVQK 9 1 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 ; 151.83 0.00014182 9225400.0 139218.0 96759.0 111527.0 119726.0 101054.0 81854.0 143130.0 111546.0 92465.0 95301.0 False True 131480.82089381028 104180.10417077791 104351.47424141652 103419.1122611303 88358.69308577772 93128.64550336909 149785.82860671452 111870.58039256553 110960.58368796244 92549.41250826529 1.4206553810600164 1.125670075555303 1.127521735830546 1.1174475283880843 0.9547191137262669 1.0062586350297154 1.6184417010031007 1.2087659700981326 1.1989334203288746 1.0 16.497936211632307 RYEDDGIS(ph)DDEIEGK ddPTM_A459_Selumetinib_30min_R1 2 RYEDDGISDDEIEGK 15 1 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 RYEDDGIS(1)DDEIEGK;RYEDDGIS(1)DDEIEGK 191.4 5.142e-05 32098000.0 10093.9 13672.5 11134.0 11745.0 10148.9 10656.8 12642.6 12053.9 6127.5 11011.7 True False 10329.068230689634 12071.717343827202 9622.06395468422 9693.956230955362 9230.933786933829 10549.602267600221 11688.958503384343 11734.191415414682 10397.919965106883 12425.158958041173 0.8313027032949937 0.9715543587484461 0.7744016786567646 0.7801877033276695 0.7429227922239062 0.8490516944874054 0.9407492123728217 0.9443896416166717 0.8368440194785336 1.0 13.600976688199045 -7.1481013410406735 4.6797947590904565 0.9254423742351172 0.8215469639216826 0.36683770218789125 0.06847788094283828 0.28879511320077206 9.930151651347769 0.028393940829805456 0.02176183460662499 7.110475739234033e-08 7.1481013410406735 -0.10389541031343463 RYEDDGIS(ph)DDEIEGK ddPTM_A459_Selumetinib_30min_R2 4 RYEDDGISDDEIEGK 15 1 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 RYEDDGIS(1)DDEIEGK;RYEDDGIS(1)DDEIEGK;RYEDDGIS(1)DDEIEGK;RYEDDGIS(1)DDEIEGK 126.04 0.00060449 65431100.0 477887.0 408732.0 456359.0 469139.0 455074.0 389813.0 444440.0 485143.0 372538.0 400074.0 True False 451327.95367323386 440080.43011947686 426997.35878611077 405241.45889008517 397903.5357068223 443506.2023799062 465107.3406411523 486554.68581025297 447056.009581421 388522.8241029129 1.1616510682875223 1.1327016144691342 1.099027733498114 1.0430312809183735 1.0241445573386045 1.141519043067671 1.197117162202943 1.2523194407785245 1.150655719168261 1.0 18.567639827903434 -6.990436971359765 24.668115403144483 1.1708023372853877 1.0911046375917017 0.10977399257675668 0.07105027488011509 275.3758591696498 710335.8425649334 0.025146088745690517 0.022148385946393952 1.0222639097770541e-07 6.990436971359765 -0.07969769969368601 RYEEDMYWR ddPTM_A459_Selumetinib_30min_R1 1 RYEEDMYWR 9 1 Q96KR1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 144.77 0.0025947 4674700.0 1299.8 1294.2 1573.7 1872.8 1399.7 1331.3 1302.0 1286.7 662.34 852.78 False True 1330.0828110294708 1142.674462342743 1360.0001837153363 1545.7506368099794 1273.0973821371065 1317.9083307236851 1203.7890917537857 1252.5725362093663 1123.9426046003894 962.2426197806286 1.3822738503649965 1.187511796768313 1.4133651490363088 1.6064042529755942 1.3230523736595103 1.3696216563595374 1.251024499443004 1.3017221545382462 1.168044920787883 1.0 9.910256890654466 -8.42485797805942 0.7738370354142199 1.000563650282742 1.3822309297866062 0.5858848702207484 0.0999731716327086 0.5082231979791216 0.6887413250113573 0.10348576060666281 0.03951048010600998 3.759603298339227e-09 8.42485797805942 0.38166727950386425 RYEPYGMYS(ph)DDDANSDASSVCSER ddPTM_A459_Selumetinib_30min_R2 1 RYEPYGMYSDDDANSDASSVCSER 24 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 RYEPYGMY(0.011)S(0.989)DDDANSDASSVCSER 101.14 2.4e-06 4930900.0 5211.8 5690.1 7592.2 6557.5 6667.1 5103.4 5198.9 6012.4 6392.0 6741.2 True False 4922.149020488443 6126.512373444787 7103.726117762344 5664.357187681542 5829.519293369763 5806.347025947344 5440.659151424917 6029.8950885935965 7670.578607402319 6546.564040258944 0.7518675430682492 0.935836315931381 1.085107557808502 0.8652412399615803 0.8904700630010457 0.8869304554634249 0.8310709431645177 0.9210778435087437 1.171695344341108 1.0 12.67652219242642 -8.1570563551866 6.506916495495791 1.0839946116813224 0.8987381492535447 0.4246645676290628 0.08860721208276919 0.22452465087279186 11.69156540635515 0.06205194626976015 0.022971979457227187 6.96536123899067e-09 8.1570563551866 -0.1852564624277777 RYESQLR ddPTM_A459_Selumetinib_30min_R1 2 RYESQLR 7 1 O15212 O15212 PFDN6 Prefoldin subunit 6 0 ; 95.531 0.032107 2125400.0 1449.72 1480.99 1406.47 1260.97 1353.3400000000001 937.1 1280.25 1181.15 793.97 1000.6600000000001 False True 1483.4956553359332 1307.5950023064286 1215.4790991866996 1040.765260838467 1230.9306359515829 927.6736248187232 1183.6797117648114 1149.8220650840851 1347.3091007255669 1129.1044582538107 1.3138692744426832 1.1580815156187216 1.0764983614239463 0.9217617141004274 1.0901831331489462 0.8216012416188618 1.0483349907194617 1.018348706958712 1.1932546106577377 1.0 10.140963246799151 -4.9465742447327825 1.6487234558773853 1.010972565500953 1.3643099055711512 0.5002337822278876 0.09331853527996252 0.5788545690539828 1.980526423479169 0.02624542951059333 0.2976163474306871 1.130904039316364e-05 4.9465742447327825 0.35333734007019824 RYESQLR ddPTM_A459_Selumetinib_30min_R2 1 RYESQLR 7 1 O15212 O15212 PFDN6 Prefoldin subunit 6 0 141.52 0.0042777 4533900.0 9220.9 8855.8 9515.9 10204.0 12014.0 7954.8 6977.9 8340.3 7984.4 8116.6 False True 8708.439292187328 9535.01138411493 8903.657354128538 8814.197597118184 10504.693913477284 9050.501493515294 7302.386176446539 8364.568892189005 9581.50310277582 7882.252668540581 1.1048160542917127 1.2096810118978794 1.129582839898619 1.1182333233616266 1.3327020022338683 1.1482125572601083 0.926433912172292 1.0611901500662915 1.2155792900444866 1.0 12.94439228100512 -7.018679681369701 24.602664843496168 1.0532461763360876 1.18117286821681 0.31262544217929245 0.09030986946910527 787.4098622069799 1037080.6325206606 0.034490645133805134 0.02721736823725517 9.579003206374795e-08 7.018679681369701 0.12792669188072225 RYFGGTEDR ddPTM_A459_Selumetinib_30min_R1 1 RYFGGTEDR 9 1 Q16658 Q16658 FSCN1 Fascin 0 99.788 0.025024 3407400.0 1853.6 1671.0 2316.6 1984.1 1768.9 1927.3 1645.9 1630.5 1071.2 1334.5 False True 1896.7852735222557 1475.3585431731753 2002.0184441729346 1637.6141811697341 1608.9033073246594 1907.9131118483883 1521.7484378783086 1587.253843389578 1817.748162647488 1505.796074130784 1.2596561420955814 0.9797864189709894 1.3295415485317912 1.0875404772954012 1.0684735702033183 1.2670461456407536 1.0105939735277454 1.0540961493114631 1.2071675533466757 1.0 10.556310687632836 -14.52287874139226 0.11425185194302982 0.5718506748449427 1.2056876341797773 0.13370673602203365 0.11258034106456588 345.0885119268449 2.5843093685892056 34.478508111466304 1.2102668126744953 3.0000000268578884e-15 14.52287874139226 0.6338369593348346 RYFGGTEDR ddPTM_A459_Selumetinib_30min_R2 3 RYFGGTEDR 9 1 Q16658 Q16658 FSCN1 Fascin 0 ;; 92.239 0.03539 6199800.0 53629.0 42991.0 48642.0 58328.0 58777.0 42685.0 38945.0 42201.0 38953.0 47798.0 False True 50648.51487389668 46288.271462147386 45512.426677405216 50383.62577858772 51392.90778695308 48564.47129414951 40756.019668053465 42323.79792324838 46744.688437756995 46417.947545881616 1.091140766700927 0.9972063374063221 0.9804920097429698 1.085434157311377 1.107177514390398 1.0462434007050003 0.8780228731089059 0.9117981332848378 1.0070391068358293 1.0 15.502395112252488 -7.220000173862244 15.345797464400151 0.9418675678345393 1.0497040903102755 0.48350249149529145 0.051441380149315014 5.250281826768004 1943.7533223050696 0.020676674170418966 0.016010023124519324 6.02559344850153e-08 7.220000173862244 0.10783652247573616 RYPSS(ph)ISSS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 RYPSSISSSPQK 12 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 2 RYPS(0.312)S(0.67)IS(0.021)S(0.317)S(0.68)PQK;RYPS(0.106)S(0.559)IS(0.33)S(0.012)S(0.993)PQK 138.31 0.004208600000000001 61157000.0 135451.0 123714.0 115189.0 123225.0 127341.0 120823.0 154574.0 132468.0 103361.0 110577.0 True False 127923.17567331457 133202.46599679257 107777.86514830071 106441.5424250185 111343.28513701604 137465.27152800822 161761.9972825701 132853.4599487422 124036.08814763956 107384.35469645042 1.1912645565075326 1.2404271215608986 1.003664504507781 0.9912202082501029 1.0368669202488254 1.2801238310421408 1.5063832877688015 1.2371770573496184 1.1550666621619095 1.0 16.712424290422817 -6.769612310195927 24.926419035169268 1.2674883386733684 1.0903134296695802 0.19101683628347388 0.13973087524083805 251.91187807773565 768295.5209537039 0.05089984325440778 0.04565096894432115 1.6997603323489182e-07 6.769612310195927 -0.17717490900378818 RYPSSIS(ph)SS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 1 RYPSSISSSPQK 12 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 2 RYPS(0.009)S(0.386)IS(0.583)S(0.207)S(0.814)PQK 118.61 0.015062 23046000.0 81856.0 65535.0 64184.0 69974.0 70570.0 73717.0 81123.0 76926.0 56450.0 67423.0 True False 77306.77121553049 70561.32377176223 60054.47131825534 60443.42048811721 61704.3656961954 83870.84761370072 84895.380242175 77149.84192421517 67741.57734478437 65476.322804008065 1.180682846942013 1.0776616760072983 0.9171937082969351 0.9231340108857982 0.9423920442340148 1.2809339929603782 1.2965813687536256 1.1782861135184661 1.0345965448847356 1.0 15.998685680876063 -6.752715703511875 24.98430726709088 1.1778788520299288 1.0022878949344032 0.29118956100473026 0.11466534772903782 226.19355846543405 647809.8176264124 0.040435389504495906 0.039843150117793345 1.767194277287815e-07 6.752715703511875 -0.17559095709552563 RYPSSISS(ph)SPQK ddPTM_A459_Selumetinib_30min_R1 4 RYPSSISSSPQK 12 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 RYPS(0.025)S(0.025)IS(0.005)S(0.75)S(0.195)PQK;RYPSSISS(0.862)S(0.138)PQK;RYPSSISS(0.5)S(0.5)PQK;RYPSSIS(0.002)S(0.666)S(0.332)PQK 156.36 0.00078049 465381000.0 13822.4 18040.9 12144.699999999999 12989.0 12938.800000000001 12207.6 14461.300000000001 13790.7 7570.200000000001 12746.4 True False 14144.435026291554 15928.66304101313 10495.516446061918 10720.714983727477 11768.487824530683 12084.802627613955 13370.472498140582 13424.925837493201 12846.076494467909 14382.524600450079 0.9834459122600024 1.1075011851893282 0.7297408999900808 0.7453986891419597 0.8182491010070935 0.8402420968037684 0.9296332090210486 0.9334192855872528 0.8931725723636802 1.0 13.812029317417489 -9.582195573100687 12.492087597766776 0.9999999866624554 0.8837217818588439 0.0915481289599368 0.10663474429637662 0.0 0.0 0.11306252759988385 0.027421690799625482 2.6170042437758336e-10 9.582195573100687 -0.1162782048036115 RYPSSISS(ph)SPQKDLTQAK ddPTM_A459_Selumetinib_30min_R1 1 RYPSSISSSPQKDLTQAK 18 2 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 RY(0.001)PS(0.214)S(0.214)IS(0.052)S(0.305)S(0.214)PQKDLTQAK 80.236 0.012923 196850000.0 1675.6 1611.1 2821.6 3213.8 2206.3 2028.5 1815.0 1639.5 917.41 1415.4 True False 1714.6382198499623 1422.4716630199307 2438.4422179393723 2652.570160497605 2006.7405545539036 2008.0951317306371 1678.093088735116 1596.0151341534595 1556.7777650246762 1597.0803771635155 1.0736079688708182 0.8906700522777085 1.5268124590386316 1.660887077711571 1.2565056732573237 1.2573538316819732 1.050725506824824 0.9993330060119153 0.974764819156805 1.0 10.641221206564126 -7.295424437550664 2.5401319839947796 0.9913646320645924 1.2933004255202063 0.3086284175150795 0.20043464561220173 0.4188846008308897 5.327013454577228 0.10807160409266371 0.07014145758063507 5.064954664821743e-08 7.295424437550664 0.30193579345561394 RYPSSISSS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 4 RYPSSISSSPQK 12 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 RYPSSISS(0.023)S(0.977)PQK;RYPSSISS(0.112)S(0.888)PQK;RYPSSISS(0.107)S(0.893)PQK;RYPSSISS(0.13)S(0.87)PQK 122.63 0.0017942999999999995 1772970000.0 595668.0 523693.0 610279.0 629549.0 600872.0 418985.0 542243.0 539929.0 446019.0 507954.0 True False 562563.157207934 563858.5691616 571014.313561535 543803.3401673994 525385.087496164 476696.38058285596 567458.3739341209 541500.1039999422 535235.262812106 493288.0481970118 1.1404354094207745 1.1430614855205317 1.1575677044043857 1.1024052623107798 1.0650675389693065 0.9663651538390214 1.1503590569611502 1.0977361117487996 1.0850359435393033 1.0 18.912070807348407 -5.988757414236696 3.301712065643006 1.0659230785041633 1.1463195216099584 0.3914337766579046 0.04796671511662229 0.28098563911548 6.418911739327509 0.014846405380292433 0.021933943504461213 1.0262249891563362e-06 5.988757414236696 0.08039644310579508 RYS(ph)DFEWLK ddPTM_A459_Selumetinib_30min_R1 1 RYSDFEWLK 9 1 A0A087X0R6;Q9UMY4-3;Q9UMY4;Q9UMY4-1 A0A087X0R6 SNX12 Sorting nexin-12 1 RYS(1)DFEWLK 117.27 0.0038943 11854000.0 4878.6 5192.5 4576.9 4084.4 3836.6 4825.6 4714.6 4428.1 3228.3 4917.1 True False 4992.261887896891 4584.559686072243 3955.3821191121083 3371.136213683618 3489.5802074067433 4777.058845294236 4358.973926253765 4310.652403504075 5478.1893142969475 5548.257681609946 0.8997891183828863 0.8263061936124665 0.7129052661383184 0.6076026758557851 0.6289506377782668 0.861001618783515 0.7856473466799968 0.7769380318783691 0.9873711043477226 1.0 12.437819077973892 -8.253132408523836 3.709490252160819 1.004195029291316 0.7553052480498507 0.5247287841176358 0.0881052516991855 0.1938634555239155 5.65690924965362 0.0854113209175193 0.02533606480706193 5.58299953239674e-09 8.253132408523836 -0.24888978124146532 RYS(ph)DFEWLK ddPTM_A459_Selumetinib_30min_R2 2 RYSDFEWLK 9 1 A0A087X0R6;Q9UMY4-3;Q9UMY4;Q9UMY4-1 A0A087X0R6 SNX12 Sorting nexin-12 1 RYS(1)DFEWLK;RY(0.003)S(0.997)DFEWLK 92.856 0.013008 4661000.0 39561.0 40005.0 42221.0 37319.0 40725.0 40960.0 35665.0 37778.0 27224.0 38496.0 True False 37362.357995230705 43073.2548636507 39504.546826749036 32236.087821134188 35608.76141388067 46601.86820214038 37323.49316885677 37887.927725515445 32669.560702115275 37384.52045538008 0.9994071754865539 1.1521681792082996 1.0567086683350477 0.8622843740796207 0.95250015193805 1.2465551954253786 0.9983675787256345 1.0134656607602124 0.8738793571287802 1.0 15.190153406745209 -8.065627214058768 4.879967466234169 0.9362246671555272 1.0394248689733672 0.12993051507773778 0.10305377403169814 0.46722853341021114 21.49821221913107 0.07573450775076895 0.027917211996977366 8.597511906542526e-09 8.065627214058768 0.10320020181783995 RYS(ph)DFEWLR ddPTM_A459_Selumetinib_30min_R1 2 RYSDFEWLR 9 1 O60493-4;O60493;O60493-3 O60493-4 SNX3 Sorting nexin-3 1 RY(0.04)S(0.96)DFEWLR;RY(0.002)S(0.998)DFEWLR 112.02 0.005099800000000001 24253000.0 4216.9 5127.0 4784.0 5431.2 5064.7 4218.8 4678.9 4066.2999999999997 2656.6000000000004 3949.5 True False 4315.145565340959 4526.728456522367 4134.359076630976 4482.742876250728 4606.598779245409 4176.362702363916 4325.966805995997 3958.4485147961036 4508.056169612882 4456.456796387805 0.9682906763145587 1.0157685047438407 0.9277233608507309 1.005898425826596 1.0336908871144677 0.9371487020246845 0.9707188925296937 0.8882501717518357 1.0115785646720283 1.0 12.121681404258087 -6.798125184072999 24.99999262931212 0.9551286332281822 0.9890838007444392 0.09607743386681589 0.041738666967342186 353.07285605209796 240603.4610941311 0.014233944740318893 0.012553548342550666 1.5917498438325098e-07 6.798125184072999 0.033955167516257045 RYS(ph)DFEWLR ddPTM_A459_Selumetinib_30min_R2 1 RYSDFEWLR 9 1 O60493-4;O60493;O60493-3 O60493-4 SNX3 Sorting nexin-3 1 RY(0.004)S(0.996)DFEWLR 77.279 0.027935 1629300.0 2034.8 2555.4 1019.7 1164.8 2349.7 1768.3 2426.3 1850.6 2079.4 2809.8 True False 1921.713961949786 2751.390963093938 954.0936121654147 1006.1522306079245 2054.5096794154797 2011.8672739708209 2539.127757622241 1855.9849396166774 2495.338103290424 2728.6737732628585 0.7042666590560819 1.0083253593938841 0.3496547009445328 0.36873306016526874 0.7529334211904578 0.7373059006482464 0.9305354793607429 0.6801783920828878 0.9144875168813532 1.0 11.413984208101992 -6.770482723448389 2.4353543312592616 0.8496026628689312 0.6179308764819551 0.2622927787496522 0.19231880444837834 0.4789026161459306 5.825496304214216 0.07880445403267075 0.07247234567804198 1.6963570832413012e-07 6.770482723448389 -0.23167178638697605 RYS(ph)GDSDSSASSAQSGPLGTR ddPTM_A459_Selumetinib_30min_R1 1 RYSGDSDSSASSAQSGPLGTR 21 1 A0A5E8;Q99501 A0A5E8 GAS2L1 GAS2-like protein 1 1 RYS(0.611)GDS(0.295)DS(0.068)S(0.019)AS(0.005)S(0.001)AQSGPLGTR 212.06 1.0118e-17 6291900.0 503.88 439.27 682.09 717.32 721.93 506.12 680.57 554.62 420.0 470.93 True False 515.6194236201951 387.8400641889173 589.4659244521785 592.0535277640613 656.6315589670934 501.02889232019186 629.2340569699498 539.9096759403424 712.7093244136909 531.378452746654 0.9703431160126992 0.7298754064719826 1.1093146916388401 1.11418429690512 1.2357135589014114 0.94288522564363 1.1841542571353576 1.0160548911036777 1.3412461885305127 1.0 9.053595917893311 -5.281465137123338 22.82688371728852 1.1187019067413357 0.8501093476603766 0.4301277697333996 0.12331287406316671 195.85922529540443 223255.52748555967 0.02992651746612826 0.06248549973024446 5.230399513931172e-06 5.281465137123338 -0.26859255908095914 RYS(ph)GNMEYVISR ddPTM_A459_Selumetinib_30min_R1 2 RYSGNMEYVISR 12 1 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 RYS(1)GNMEYVISR;RY(0.003)S(0.997)GNMEYVISR 125.47 0.0051582 22875900.0 3513.3900000000003 4110.4 3989.1 3810.6 3925.2 4250.5 4153.49 3085.3199999999997 2271.7799999999997 2696.85 True False 3595.2451511331246 3629.152457126884 3447.4021305578226 3145.1502438210728 3570.166353050347 4207.743829145214 3840.1889053060163 3003.4872910682197 3855.0447357536505 3043.016967043539 1.181473908975968 1.192616569815846 1.1328895526688985 1.03356316375612 1.1732324833268883 1.3827539822208983 1.2619676284739794 0.9870097089817661 1.266849569852725 1.0 11.571286662616249 -11.013910239551628 2.905180739714884 0.9941508519513212 1.1765030236704612 0.19827565078686105 0.10795502034241788 18436499.259954758 20329617.09850589 862205.1951397156 0.029209007464711972 9.684780016474088e-12 11.013910239551628 0.18235217171913998 RYS(ph)GNMEYVISR ddPTM_A459_Selumetinib_30min_R2 2 RYSGNMEYVISR 12 1 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 RY(0.019)S(0.981)GNMEYVISR;RY(0.001)S(0.999)GNMEYVISR 127.66 0.0013147 21840000.0 26225.0 26510.0 27189.0 31001.0 29865.0 28839.0 28203.0 25478.0 20913.2 28747.0 True False 24767.519486992867 28543.231756914876 25439.689341144927 26778.610320292108 26113.091703512488 32811.310475623235 29514.495383184305 25552.13676189003 25096.424363630504 27916.999416324077 0.8871841531977253 1.0224319358700356 0.9112615923282007 0.9592223691717272 0.9353831804804645 1.1753165154431775 1.0572230540623972 0.9152895116281291 0.8989656799919449 1.0 14.768856265229456 RYS(ph)PDELR ddPTM_A459_Selumetinib_30min_R1 3 RYSPDELR 8 1 S5FZ81;Q8WUB8-2;Q8WUB8;Q8WUB8-3 S5FZ81 PHF10 PHD finger protein 10 1 RY(0.157)S(0.843)PDELR;RY(0.382)S(0.618)PDELR;RY(0.222)S(0.778)PDELR 96.334 0.010864 9049300.0 1937.21 1879.5100000000002 2312.05 2372.22 2122.51 2089.46 2047.09 2258.98 1122.63 1695.12 True False 1982.3432238455155 1659.456095439507 1998.0863091815743 1957.956309084455 1930.5293452595772 2068.441929477887 1892.6763531783865 2199.0645121988287 1905.0211163489082 1912.705163867046 1.0364081518124193 0.8675963900701098 1.0446389474590572 1.0236581915876264 1.0093188337278782 1.0814222539641067 0.9895285425757069 1.1497143175756532 0.9959826283405842 1.0 10.901398789601261 -5.313946264131348 24.99122030720555 1.0405869374460026 0.9520021116209605 0.24360457730373541 0.05945546000605048 354.4059557378411 168682.61003073692 0.014431443190156762 0.030041483877774916 4.853485493074654e-06 5.313946264131348 -0.08858482582504212 RYS(ph)PDELR ddPTM_A459_Selumetinib_30min_R2 2 RYSPDELR 8 1 S5FZ81;Q8WUB8-2;Q8WUB8;Q8WUB8-3 S5FZ81 PHF10 PHD finger protein 10 1 RY(0.007)S(0.993)PDELR;RY(0.065)S(0.935)PDELR 105.36 0.007283299999999999 16732300.0 32801.0 30296.0 38629.0 42533.0 40615.0 28387.0 31166.0 31140.0 30127.0 34785.0 True False 30978.051732806627 32619.60578300616 36143.65219607515 36739.9320264825 35512.58059729312 32297.051578470677 32615.280754257423 31230.612244495485 36153.24181871242 33780.66666771604 0.9170349430200011 0.9656294265554121 1.069950825766781 1.0876023373924295 1.0512693827689392 0.9560809410945331 0.9655013938913062 0.924511423995737 1.0702347047894065 1.0 15.043910179823655 -9.539213713769076 16.282596230433636 1.000000246360483 1.0012938785084922 0.0 0.060832305039863685 0.0 0.0 0.06344284003090316 0.015387148860975187 2.8892577456793575e-10 9.539213713769076 0.0012936321480092605 RYS(ph)PPIQR ddPTM_A459_Selumetinib_30min_R2 3 RYSPPIQR 8 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RY(0.123)S(0.877)PPIQR;RY(0.025)S(0.975)PPIQR;RY(0.32)S(0.68)PPIQR 77.533 0.027292 2419410000.0 86265.0 91483.7 87026.0 79140.0 96286.0 70317.6 72769.0 77179.0 73460.0 95290.0 True False 81470.73664615599 98500.20562354111 81426.84190674454 68360.99547588531 84189.69187223839 80003.21112038163 76152.90268903802 77403.57811232872 88154.0526438948 92538.73010684684 0.8803960952575041 1.0644214104711731 0.8799217561417547 0.7387284804638502 0.9097779035332719 0.8645375944537873 0.8229300596745875 0.8364452162133325 0.9526179205410599 1.0 16.497769680731402 -5.492269957235701 23.75351560475701 0.8625943378712869 0.9723495519845301 0.17935183190662918 0.07984176477595391 484.7473703685478 376179.34021548566 0.019780117296745687 0.041069842225641286 3.2190671986707603e-06 5.492269957235701 0.10975521411324318 RYS(ph)PSPPPK ddPTM_A459_Selumetinib_30min_R1 1 RYSPSPPPK 9 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RY(0.001)S(0.99)PS(0.009)PPPK 106.62 0.023458 7312400.0 2752.2 2993.5 3109.6 3417.5 2875.3 2602.3 3045.7 2589.1 1623.1 1981.2 True False 2816.320905151033 2643.019628359605 2687.3333998101366 2820.6977794201757 2615.229622675446 2576.123224699351 2815.960396892862 2520.428657417945 2754.282153466334 2235.5063185222252 1.2598134399426586 1.1822912807094035 1.202113980866129 1.2617713294072859 1.16986008986288 1.1523667830213469 1.2596521752416 1.1274531574950175 1.2320618960661422 1.0 11.126385908237921 -13.9387042400745 0.2767158328163002 7.509160492640625e-10 1.21680773143304 0.6519674612878433 0.045086833930693376 92.59726477955648 1.207707618518824 52.64130876431763 0.05038341932491119 1.1515843651925952e-14 13.9387042400745 1.2168077306821241 RYS(ph)PSPPPK ddPTM_A459_Selumetinib_30min_R2 1 RYSPSPPPK 9 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 RY(0.006)S(0.982)PS(0.012)PPPK 65.842 0.044676 10349000.0 62478.0 49454.0 64830.0 62862.0 63892.0 43782.0 49377.0 49999.0 39576.0 55732.0 True False 59005.722879250345 53246.96278032703 60658.90838156699 54300.087157001464 55865.31575827286 49812.57308657499 51673.12833866933 50144.488812219955 47492.305845831404 54122.87235087393 1.0902178749258042 0.9838162770654807 1.1207629186477854 1.0032743052692892 1.0321942153421353 0.9203608552710277 0.9547373613816518 0.9264934885040385 0.8774904912278652 1.0 15.7239507860553 -6.70782392091984 4.853625464722676 0.9321851672879815 1.045999350768416 0.5843040740032002 0.04649909235663377 0.1405875984586408 6.900420615570525 0.015092916165686622 0.014756429252709374 1.959639022759962e-07 6.70782392091984 0.11381418348043448 RYSGDS(ph)DSSASSAQSGPLGTR ddPTM_A459_Selumetinib_30min_R1 1 RYSGDSDSSASSAQSGPLGTR 21 1 A0A5E8;Q99501 A0A5E8 GAS2L1 GAS2-like protein 1 1 RYS(0.405)GDS(0.594)DSSASSAQSGPLGTR 225.69 1.7793e-21 5458400.0 849.89 1095.1 1021.4 1203.7 1239.4 1039.1 1044.1 1240.0 683.09 918.37 True False 869.6907834019366 966.8851829018223 882.6994901485953 993.4963912474218 1127.2964888338422 1028.6475974273128 965.3426963902671 1207.1111719123453 1159.1538390803523 1036.2517351813322 0.83926593691035 0.9330601340152435 0.8518195532807797 0.958740388573218 1.087859687527161 0.9926618817649664 0.9315716091142112 1.1648821718992004 1.1186025554664223 1.0 10.017158802147076 -5.9853826007203645 0.6965104139136745 1.0710896560139516 0.8416295912733016 0.5372226949916823 0.07010732701416669 0.7839837362044969 0.7342642967434246 0.042303901491856324 0.11260079809729062 1.0342306383181976e-06 5.9853826007203645 -0.22946006474064995 RYWEEETVPTTAGAS(ph)PGPPR ddPTM_A459_Selumetinib_30min_R1 2 RYWEEETVPTTAGASPGPPR 20 1 O15213 O15213 WDR46 WD repeat-containing protein 46 1 RYWEEETVPTTAGAS(1)PGPPR;RYWEEETVPTTAGAS(1)PGPPR 258.16 3.2572999999999997e-47 18057400.0 1535.38 1991.67 2073.6000000000004 2225.46 1873.9700000000003 1632.8 1666.5099999999998 1654.9499999999998 1037.1599999999999 1385.99 True False 1571.1513666705875 1758.4843504977378 1792.0165094694805 1836.825188058061 1704.4697443762752 1616.3755144637828 1540.8038089851007 1611.0553499647865 1759.9847688307227 1563.895317185855 1.0046397283788722 1.1244258686457578 1.1458673031223836 1.1745192711257224 1.0898873637165027 1.0335573594352614 0.9852346202798878 1.0301554920336953 1.125385279621989 1.0 10.610928230535402 -6.653207814737339 4.145023847142432 1.0336584419699288 1.117230260225669 0.31917851080556103 0.05370215081387255 0.2664800460105771 8.295609342720645 0.01899318238303019 0.018817286668304935 2.2222462666519926e-07 6.653207814737339 0.08357181825574012 RYWEEETVPTTAGAS(ph)PGPPR ddPTM_A459_Selumetinib_30min_R2 2 RYWEEETVPTTAGASPGPPR 20 1 O15213 O15213 WDR46 WD repeat-containing protein 46 1 RYWEEETVPTT(0.002)AGAS(0.998)PGPPR;RYWEEETVPTTAGAS(1)PGPPR 144.73 1.5507999999999998e-05 56002000.0 72120.0 78317.0 80122.0 74939.0 84717.0 68463.0 67567.0 59468.0 59237.0 75657.0 True False 68111.85911923456 84323.66207115438 74967.03775023752 64732.17892301441 74074.09308041069 77893.15680476408 70708.99938147055 59641.042034542654 71086.05522007047 73472.58582950673 0.9270377291101236 1.1476887756043812 1.0203402657448135 0.8810385287544602 1.0081868256590256 1.0601662637206657 0.9623861550966902 0.8117455151631631 0.9675180806216048 1.0 16.164918429968843 -7.5245511189569045 24.9920158013852 0.9111922400429363 1.0088825873084184 0.1613511296365815 0.08125311662387466 86.16003316347928 1287504.2742254415 0.03795599984201552 0.022112398469165993 2.988469866175086e-08 7.5245511189569045 0.09769034726548209 S(ph)AASPVVSSMPER ddPTM_A459_Selumetinib_30min_R1 1 SAASPVVSSMPER 13 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 S(0.994)AAS(0.006)PVVSSMPER 231.69 3.2646e-13 47114000.0 1917.0 1950.6 2019.4 1857.1 1973.3 1748.4 1860.7 1812.0 825.02 1436.6 True False 1961.6623701673318 1722.2228451906617 1745.176571770191 1532.7923470844796 1794.8153634144107 1730.812683420185 1720.3459009418352 1763.93987379449 1399.9986829232935 1621.0016036690029 1.210154490734168 1.0624436405815718 1.0766038527168194 0.9455834859232286 1.1072261491611082 1.0677427335683283 1.0612857489147296 1.088178981317451 0.8636627377508526 1.0 10.662669802787235 -4.3171034378313635 1.451431749959942 1.03118396238907 1.5682764793499495 0.3788724335088973 0.07039507729672041 4.387771302632432 3.3994508168897783 0.019460479862460803 4.758489120593655 4.818330236621293e-05 4.3171034378313635 0.5370925169608796 S(ph)AASPVVSSMPER ddPTM_A459_Selumetinib_30min_R2 2 SAASPVVSSMPER 13 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 S(0.994)AAS(0.006)PVVSSMPER;S(1)AASPVVSSMPER 237.41 1.245e-17 148740000.0 102115.0 105815.0 122056.0 130699.0 141485.0 109564.0 114482.0 138267.0 115246.0 111375.0 True False 96439.85709873313 113930.67025114868 114203.04984452497 112897.57073164902 123710.38940805176 124655.44647703394 119805.63984177956 138669.33407866603 138298.42024228533 108159.31436299783 0.8916463428666666 1.0533597676921413 1.0558780861095654 1.0438081213491142 1.1437793419516542 1.152516981188257 1.1076775083807857 1.2820840710331456 1.2786547423750896 1.0 16.722798385753144 -4.856113422064313 0.5025378498971109 1.1883565126990263 0.7617181813365828 0.4780483833705992 0.08252773763962602 3.5916326684062336 0.7368573812574498 0.053122093088846675 0.9018125847306291 1.3927930081125187e-05 4.856113422064313 -0.42663833136244356 S(ph)ADNTLER ddPTM_A459_Selumetinib_30min_R2 1 SADNTLER 8 0 A0A087WT53;Q96QZ7-7;Q96QZ7-6;Q96QZ7-2;Q96QZ7 A0A087WT53 MAGI1 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 1 S(1)ADNTLER 111.5 0.011574 9041300.0 16616.0 18318.0 14087.0 19070.0 15259.0 13820.0 15592.0 11540.0 10157.0 12206.0 True False 15692.54923911815 19722.93169834653 13180.657756765917 16472.633102415104 13342.028002809213 15723.579554530766 16317.05889496186 11573.579489450163 12188.683810291823 11853.58106500336 1.323865686923001 1.6638795980884395 1.1119557612577209 1.389675661058166 1.1255693895071388 1.326483487842609 1.3765510022229923 0.9763783135224952 1.0282701694492835 1.0 13.533035354642523 -6.7800845113264145 0.29150599455512605 0.9430086278724598 1.5405462272173631 0.42898466086931253 0.15779505449463346 2.4857663220716772 0.4507160524516609 0.23361993257098534 0.5194721759214553 1.6592639923390335e-07 6.7800845113264145 0.5975375993449034 S(ph)ADTLWDIQK ddPTM_A459_Selumetinib_30min_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 S(1)ADTLWDIQK 126.12 0.0035106 1961500.0 1369.7 1418.3 1568.3 1473.4 1564.9 1608.7 1437.1 1531.3 782.1 1180.9 True False 1401.6113450277473 1252.2447766502187 1355.3334740552589 1216.0983491434338 1423.3550713055342 1592.5179385827334 1328.6983899841528 1490.6849496365905 1327.1665776760656 1332.4800179400834 1.0518816989049757 0.9397850322634462 1.0171510685394782 0.9126578506020923 1.068199937066176 1.1951533359912216 0.9971619627273836 1.1187296841727357 0.996012367771014 1.0 10.379898182948676 -6.357754000814223 9.644487924663547 1.072077920846243 0.9801654547743845 0.2515341637732512 0.0682813924702857 0.5217785476625574 48.98745263014272 0.020269433600364383 0.02298095543029977 4.3877916686174264e-07 6.357754000814223 -0.09191246607185843 S(ph)ADWTEELGAR ddPTM_A459_Selumetinib_30min_R1 2 SADWTEELGAR 11 0 Q9NZ56 Q9NZ56 FMN2 Formin-2 1 S(1)ADWTEELGAR;S(1)ADWTEELGAR 155.88 0.00054005 7542500.0 992.4300000000001 1300.53 1596.99 1667.14 1450.4499999999998 1109.0 1216.35 1164.81 642.21 793.06 True False 1015.5516880673786 1148.263343000006 1380.1275296381489 1376.0052950936513 1319.2570535977466 1097.8444668914344 1124.5997402109965 1133.915454963885 1089.7834648374198 894.8569760585682 1.1348759804504345 1.2831808587530666 1.542288395310917 1.5376818105104564 1.4742658200067509 1.2268379151793982 1.256736853261556 1.2671471366946916 1.217829769442501 1.0 9.805513306319565 -6.80538368641873 9.565539660327579 1.2139738006188843 1.404375032517883 0.3535096393903988 0.13401775191426873 0.48647317883493796 100.99567427916521 0.050535850277155916 0.04471393344195568 1.5653675028166076e-07 6.80538368641873 0.1904012318989987 S(ph)ADWTEELGAR ddPTM_A459_Selumetinib_30min_R2 2 SADWTEELGAR 11 0 Q9NZ56 Q9NZ56 FMN2 Formin-2 1 S(0.983)ADWT(0.017)EELGAR;S(1)ADWTEELGAR 190.66 1.985e-05 5100400.0 9190.5 6699.1 11352.4 11920.6 12550.4 8804.3 8914.8 11363.8 8685.8 8625.8 True False 8679.728802486488 7212.899428998431 10621.998943558554 10296.993715818007 10973.706550000434 10017.012407522094 9329.355864341072 11396.86677662163 10423.202701529262 8376.750741480091 1.036168924008459 0.8610617232862753 1.268033306871651 1.2292348230954557 1.310019468009321 1.1958112061183503 1.1137201227850628 1.3605355021710857 1.2443014031580917 1.0 13.032175029996049 -5.2673711494162685 24.995037300034483 1.2276531708590408 0.9486153173364704 0.5112975860610482 0.10368415653338435 303.3460667542847 1278231.0134673805 0.02567802626390354 0.05577711435546593 5.402923900304975e-06 5.2673711494162685 -0.2790378535225704 S(ph)AEDELAMR ddPTM_A459_Selumetinib_30min_R2 1 SAEDELAMR 9 0 Q13868-3;Q13868;A3KFL1;A3KFL5;A3KFL2;Q13868-2 Q13868-3 EXOSC2 Exosome complex component RRP4 1 S(1)AEDELAMR 136.49 0.0026355000000000003 10327000.0 19405.0 20068.0 19543.0 20414.0 26200.0 11570.0 16373.0 22717.0 13683.0 18495.0 True False 18326.54778436976 21607.151071209646 18285.624656809556 17633.577983885785 22908.5217690282 13163.662477997184 17134.37694248401 22783.1027089982 16419.982334963388 17961.001294219 1.0203522333840271 1.2030037032603638 1.0180737898334788 0.9817703197628185 1.275459056751008 0.7329024847982218 0.953976711086756 1.2684762021776181 0.9142019459821757 1.0 14.13258015958049 -6.729980185411097 24.999999124309962 0.9894444329534116 1.094378962477561 0.14845264335158126 0.148079725104111 489.40984347627386 388923.05876995437 0.04968557728736478 0.04968109923904991 1.8621720959113984e-07 6.729980185411097 0.1049345295241495 S(ph)AEEGELAESK ddPTM_A459_Selumetinib_30min_R1 3 SAEEGELAESK 11 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(1)AEEGELAESK;S(1)AEEGELAESK;S(1)AEEGELAESK 193.15 1.9488e-05 63240000.0 6128.9 7495.5 4824.6 4885.2 5548.799999999999 4978.2 6189.2 6919.5 3758.9 5430.799999999999 True False 6271.691445236599 6617.923375436584 4169.4458196308115 4032.0915265613553 5046.912019720207 4928.123827843951 5722.343661046491 6735.972382296349 6378.578760806245 6127.8960804716835 1.0234656989734472 1.0799666457344985 0.6804041329809686 0.6579895405554907 0.8235962153150174 0.8042113905209402 0.9338186525849219 1.099230844296214 1.0409084418277643 1.0 12.581176116282107 -7.543072698622586 4.0428832662041785 1.0509772335585583 0.839713403061285 0.3412242889188577 0.1252326601453821 0.26850673519645224 10.02035350333174 0.06874355801606553 0.03967158006562208 2.863698561635736e-08 7.543072698622586 -0.21126383049727337 S(ph)AEEGELAESK ddPTM_A459_Selumetinib_30min_R2 2 SAEEGELAESK 11 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(1)AEEGELAESK;S(1)AEEGELAESK 178.15 6.071600000000001e-05 136757000.0 103401.0 67892.0 74474.0 91120.0 89022.0 65657.0 92413.0 104323.0 76457.0 68488.0 True False 97654.38636699897 73099.09809281272 69682.42392116018 78709.29880923264 77838.26049322236 74700.65577509595 96710.38761288549 104626.56265839766 91750.5363870713 66510.57348680569 1.4682535610126946 1.099059807495331 1.0476894164051032 1.1834103163288303 1.1703140780866046 1.1231395529902475 1.4540603477441194 1.573081649629038 1.3794879757768543 1.0 16.021296090154124 -7.26050123928373 24.987597022227117 1.399414302303735 1.1716397153622016 0.16322552007612035 0.1744073559569904 111.11931496178933 2959743.984293895 0.06714226564347094 0.048966541183532906 5.489069892678437e-08 7.26050123928373 -0.22777458694153352 S(ph)AEPRPELGPGQET(ph)GTNSR ddPTM_A459_Selumetinib_30min_R2 1 SAEPRPELGPGQETGTNSR 19 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 2 S(1)AEPRPELGPGQET(0.446)GT(0.23)NS(0.324)R 72.158 0.044536 8135500.0 33421.0 37412.0 41689.0 35128.0 43980.0 32235.0 40725.0 35692.0 27873.0 34403.0 True False 31563.59461486325 40281.38010145979 39006.77512755123 30343.50580082002 38454.83921381145 36675.078649804585 42618.79319505659 35795.85781087131 33448.378836690346 33409.69600027123 0.9447435443473358 1.2056793363559122 1.1675285859301012 0.9082245405816828 1.1510083543860818 1.0977375744306936 1.275641454346385 1.0714212368343823 1.0011578326369328 1.0 15.027979234988077 -8.147473800274394 4.522363972671197 1.001884291840326 1.1107642902859047 0.1354116891032523 0.10500363936658351 0.44486656926934054 14.10324233625535 0.07728489665029478 0.02708725037318318 7.120757561671347e-09 8.147473800274394 0.10887999844557883 S(ph)AEPRPELGPGQETGT(ph)NSR ddPTM_A459_Selumetinib_30min_R2 1 SAEPRPELGPGQETGTNSR 19 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 2 S(1)AEPRPELGPGQET(0.04)GT(0.627)NS(0.334)R 102.69 0.003595300000000001 11514000.0 59559.0 44801.0 61393.0 64514.0 66634.0 59706.0 72007.0 59632.0 55021.0 56463.0 True False 56248.94921356756 48237.0926420801 57443.04121964432 55727.08190714252 58262.841204481876 67929.95954289542 75355.46817916364 59805.51924739096 66026.7374151882 54832.76648150782 1.0258273077018163 0.87971291140942 1.0476042867364135 1.0163098724179147 1.0625552008967274 1.2388570539442796 1.3742780642770787 1.0906894378119731 1.2041474769918004 1.0 15.742750643416999 -6.5681879844284 3.3755385771518354 1.198662774519464 0.990738072322846 0.43536990453211866 0.10088684196074446 0.21394643878461717 5.04385870693305 0.034578771353386085 0.03565437345815468 2.702788208614748e-07 6.5681879844284 -0.20792470219661796 S(ph)AEPSPTVMSTSLGSNLSELDR ddPTM_A459_Selumetinib_30min_R1 2 SAEPSPTVMSTSLGSNLSELDR 22 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 S(0.994)AEPS(0.006)PTVMSTSLGSNLSELDR;S(1)AEPSPTVMSTSLGSNLSELDR 202.21 2.1039e-35 0.0 1513.17 1708.4 1705.56 1634.1100000000001 1609.47 1246.8600000000001 1584.6999999999998 1338.57 737.4000000000001 1204.37 True False 1548.4239168837244 1508.3797337863866 1473.9543199704692 1348.7433645437613 1463.8937226750081 1234.3177204582994 1465.1648031507104 1303.0667753118603 1251.3139424348942 1358.9626210572435 1.1394161199806099 1.1099493911119496 1.0846172640302385 0.9924801047835062 1.077214119058058 0.908279375262012 1.0781494505057423 0.958868739375703 0.920786137194413 1.0 10.408290059268511 -5.163134388951552 0.5220087912001936 0.9702324432338728 1.2217226186355719 0.5467313285600403 0.05211247559932609 2.283292888509263 0.63370211793125 0.03245785018403045 0.3344400332058722 6.8685586507592e-06 5.163134388951552 0.25149017540169905 S(ph)AESPSWTPAEHVAK ddPTM_A459_Selumetinib_30min_R2 1 SAESPSWTPAEHVAK 15 0 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 S(0.497)AES(0.497)PS(0.007)WTPAEHVAK 114.58 0.0016415 20401000.0 80212.0 78010.0 84632.0 95653.0 91581.0 66776.0 68979.0 78085.0 66529.0 86463.0 True False 75754.13815407708 83993.11615831482 79186.8692603545 82624.89638937122 80075.77603547224 75973.78786782542 72186.66017929537 78312.21442233233 79836.65897557404 83966.58853214707 0.9021938306457954 1.0003159307366358 0.943075938235092 0.9840211188017699 0.9536623725616147 0.904809748686389 0.8597069553642556 0.9326592373387906 0.9508146081820168 1.0 16.35752775329869 -6.648275818947585 6.371643188138974 0.9211712428079152 0.9604990498711867 0.07748744160773058 0.04137825909282215 0.390749002664176 20.392447497802916 0.0134817789881664 0.013445324941081476 2.2476266923884598e-07 6.648275818947585 0.03932780706327155 S(ph)AESPTSPVTSETGSTFK ddPTM_A459_Selumetinib_30min_R1 1 SAESPTSPVTSETGSTFK 18 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.768)AES(0.231)PT(0.001)SPVTSETGSTFK 149.31 0.00017286 36281000.0 1980.0 2488.4 1909.7 2172.4 2099.7 1813.4 2083.8 1903.7 1031.9 1638.4 True False 2026.1301475906705 2197.0569711742237 1650.373229231224 1793.0311209985034 1909.7825057321434 1795.1588424354634 1926.6172883229945 1853.2076919109115 1751.0589330059215 1848.704599367461 1.0959729035584789 1.1884305215262365 0.8927187338614853 0.9698851409857441 1.033038218429045 0.9710360665785553 1.0421444772638049 1.0024358096718056 0.9471815743873039 1.0 10.852299002603507 -5.250797701254112 24.997718487879133 0.9854949910446115 1.1422017220057155 0.6628097342247684 0.045573245477930166 418.1012578153205 982131.7039966517 0.011597344802693239 0.03001236171212562 5.613093787104439e-06 5.250797701254112 0.156706730961104 S(ph)AEVDDGAAEK ddPTM_A459_Selumetinib_30min_R2 1 SAEVDDGAAEK 11 0 H7C5W6;F5H619;Q86XA9-2;Q86XA9 H7C5W6 HEATR5A HEAT repeat-containing protein 5A 1 S(1)AEVDDGAAEK 85.973 0.034119 4876200.0 28211.0 21748.0 23187.0 29111.0 30395.0 19458.0 22941.0 24395.0 21190.0 20857.0 True False 26643.145557580774 23416.001669158235 21695.173664096757 25146.03158072396 26576.508365252368 22138.162877862487 24007.801956729094 24465.985411190355 25428.592098068693 20254.804217005996 1.3153988195655382 1.1560714889309118 1.0711124843103357 1.241484800905223 1.3121088745423988 1.0929833061173317 1.185289262710921 1.2079102394210575 1.2554350970580486 1.0 14.30597651954691 -10.821701341722536 3.970708410745053 0.9996725986810342 1.1994218699397878 0.3795936719928744 0.07810204253897228 6807097.734870773 18552040.683309916 10582.517040622797 0.01915903942568364 1.507643495248771e-11 10.821701341722536 0.19974927125875364 S(ph)AGEEEDGPVLTDEQK ddPTM_A459_Selumetinib_30min_R1 4 SAGEEEDGPVLTDEQK 16 0 H7BZV4;A0A0C4DG62;Q66PJ3-4;Q66PJ3-3;F5H7X4;Q66PJ3-7;Q66PJ3;F5GYV5;F8WCT1;Q66PJ3-2 H7BZV4;F5H7X4;Q66PJ3 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 S(1)AGEEEDGPVLTDEQK;S(1)AGEEEDGPVLTDEQK;S(1)AGEEEDGPVLTDEQK;S(1)AGEEEDGPVLTDEQK 398.31 2.1793999999999977e-303 383255000.0 11321.2 12942.8 15595.099999999999 15369.7 12275.7 12293.099999999999 13494.2 11625.7 7523.300000000001 10098.6 True False 11584.961932779544 11427.450959055526 13477.371077752448 12685.67042000125 11165.36510245086 12169.442575241748 12476.321629757254 11317.348670404315 12766.490619908374 11394.853678693993 1.0166836941874045 1.002860701969564 1.1827594682459441 1.1132806771991128 0.9798603314518879 1.0679770814430092 1.0949084544267016 0.9931982445343203 1.1203733702854874 1.0 13.476094778625859 -6.183911833160067 24.999999993764376 1.046245047008 1.080883737883907 0.07197583738130187 0.062715578188059 383.7664777878321 123749.21036250431 0.019066065048461336 0.024614183576881492 6.547690863289021e-07 6.183911833160067 0.034638690875906875 S(ph)AGEEEDGPVLTDEQK ddPTM_A459_Selumetinib_30min_R2 4 SAGEEEDGPVLTDEQK 16 0 H7BZV4;A0A0C4DG62;Q66PJ3-4;Q66PJ3-3;F5H7X4;Q66PJ3-7;Q66PJ3;F5GYV5;F8WCT1;Q66PJ3-2 H7BZV4;F5H7X4;Q66PJ3 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 S(1)AGEEEDGPVLTDEQK;S(1)AGEEEDGPVLTDEQK;S(1)AGEEEDGPVLTDEQK;S(1)AGEEEDGPVLTDEQK 266.44 7.8379e-41 635545000.0 217785.0 204326.0 204073.0 216432.0 193867.0 163168.0 189706.0 165852.0 132487.0 201140.0 True False 205681.38156243067 219997.14718835865 190943.16535788236 186953.58823397546 169511.69426703002 185642.9109083702 198527.70489530754 166334.6018617234 158988.10199607513 195332.56557551786 1.052980494862296 1.1262696854473309 0.9775285795038693 0.9571040429594778 0.8678107194649773 0.9503940644070354 1.0163574328242486 0.8515456773510534 0.8139354619524949 1.0 17.575572967838077 -5.50719784890596 2.360317842149309 0.9178598340177471 1.0905497967873679 0.5175718938231413 0.06329808837310258 0.24011756232294923 2.632244964605502 0.018678014316010464 0.045111773390925584 3.1102990741980138e-06 5.50719784890596 0.1726899627696208 S(ph)AGNIPLSPLAR ddPTM_A459_Selumetinib_30min_R2 1 SAGNIPLSPLAR 12 0 H7C1I9;O15021-2;O15021-3;O15021-6;O15021 H7C1I9 MAST4 Microtubule-associated serine/threonine-protein kinase 4 1 S(0.995)AGNIPLS(0.005)PLAR 83.633 0.046585 0.0 11574.0 10818.0 12776.0 11988.0 12289.0 8142.0 8862.2 12932.0 8976.5 11087.0 True False 10930.763414392966 11647.705814647503 11954.006069457038 10355.213719546531 10745.145954946092 9263.486594282893 9274.309860116156 12969.62997899215 10772.050824365911 10766.88950251453 1.0152201721620868 1.0818078714309518 1.1102562227155082 0.9617646505175097 0.9979805172549268 0.8603679449036299 0.86137318098697 1.204584664490444 1.0004793698170837 1.0 13.394313902649584 -5.769090808668895 24.975642092449807 0.9826648811384453 1.070366070409882 0.1523077663312432 0.0921786734919245 336.69409718967694 1099033.8744106016 0.027844248395933496 0.04219716711767932 1.701802633300975e-06 5.769090808668895 0.08770118927143677 S(ph)AGSMCITQFMK ddPTM_A459_Selumetinib_30min_R2 1 SAGSMCITQFMK 12 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(1)AGSMCITQFMK 111.12 0.0069335 1580700.0 8127.2 6961.9 7582.4 10722.0 10651.0 7870.7 6386.4 6318.8 8178.3 9057.1 True False 7675.522759759338 7495.855343963247 7094.556639092912 9261.645103518338 9312.926158851875 8954.81748189908 6683.380254411524 6337.186661866346 9814.188520794494 8795.597989828118 0.8726550222777214 0.8522280523316333 0.8066031038819171 1.0529864045888855 1.058816713726802 1.0181021793236906 0.7598551300480855 0.7204952601511732 1.115806853853979 1.0 13.102565950776825 -5.7339347555121085 24.962475049514456 0.9473107782194262 0.8446686410602674 0.1560028232863201 0.12192363569564861 503.936285303039 457355.48288114916 0.03589839539327982 0.06215933109129803 1.8452926184850823e-06 5.7339347555121085 -0.10264213715915882 S(ph)AKSEESLTSLHAVDGDSK ddPTM_A459_Selumetinib_30min_R2 1 SAKSEESLTSLHAVDGDSK 19 1 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 1 S(0.365)AKS(0.365)EES(0.157)LT(0.089)S(0.024)LHAVDGDSK 54.65600000000001 0.033076999999999995 6700900.0 38258.0 35198.0 46859.0 54915.0 53523.0 31013.0 33741.0 38002.0 28236.0 48955.0 True False 36131.77351890845 37897.57342059186 43844.142956221614 47435.48226634111 46798.96223830898 35284.7592420161 35310.023356523125 38112.579528430244 33883.98897975782 47541.54194963458 0.7600042412841044 0.7971464926556333 0.9222280380108415 0.9977691156209063 0.9843804033089149 0.7421879433232669 0.7427193546631385 0.8016689818097747 0.712723811433261 1.0 15.536901075573072 -6.777641023388479 24.986721159984274 0.7838930330808185 0.8945404920662376 0.16358420046338074 0.10129039273708414 395.8086383015715 610425.6248760774 0.03684372683128202 0.03259053643808987 1.6686258857820424e-07 6.777641023388479 0.11064745898541917 S(ph)ALAAAILATTLTGR ddPTM_A459_Selumetinib_30min_R1 1 SALAAAILATTLTGR 15 0 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 S(1)ALAAAILATTLTGR 87.51899999999998 0.018573 1053300.0 308.71 331.35 651.6 636.0 580.28 328.73 365.36 251.96 297.94 418.15 True False 315.902342354907 292.555387959564 563.1162989825973 524.9345391986045 527.7937764567549 325.4232746629588 337.8006010469763 245.27720231857603 505.5824193233687 471.8236256259176 0.6695348117335865 0.6200524349993332 1.1934889827434383 1.1125651847175528 1.1186251552295368 0.6897138188687665 0.7159467705731195 0.5198493441128412 1.0715496042672026 1.0 8.882103850234204 -6.781505195904821 24.997336275312296 0.764185914555809 0.9482726380358916 0.07989835902361853 0.2278641390707673 549.893090551313 685034.2245996286 0.08501174143680341 0.07506599886745545 1.6538449980299303e-07 6.781505195904821 0.1840867234800826 S(ph)ALAAAILATTLTGR ddPTM_A459_Selumetinib_30min_R2 2 SALAAAILATTLTGR 15 0 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 S(1)ALAAAILATTLTGR;S(1)ALAAAILATTLTGR 122.96 0.0016813 0.0 510.18 897.68 739.24 357.67 655.46 574.96 0.0 430.16 744.54 600.05 True False 481.8262380123555 966.529169503861 691.6781032236556 308.95472898483524 573.1152549132526 654.1555210327791 0.0 431.4116943831782 893.4688041857511 582.7249973828661 0.8268501268631566 1.6586368764764439 1.1869717385218062 0.5301895926421766 0.9835089578913332 1.1225801604028 0.0 0.7403349715916323 1.5332597849731815 1.0 9.186671389642674 -5.600567846942523 7.737889992869986 0.8168789037491275 1.286957105096914 0.14291640614614054 0.42111746661436245 0.38565384761570437 32.94124887644387 0.11526376372496266 0.20046879916667137 2.508604246271241e-06 5.600567846942523 0.47007820134778644 S(ph)ALSGHLETVILGLLK ddPTM_A459_Selumetinib_30min_R1 1 SALSGHLETVILGLLK 16 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 S(0.571)ALS(0.429)GHLETVILGLLK 122.14 0.00097201 7398100.0 2794.4 2625.1 2417.7 2516.8 3773.6 2377.2 2813.4 3666.7 1025.3 2485.1 True False 2859.5040830441253 2317.752071624118 2089.3896194754834 2077.2881261871817 3432.27854628319 2353.2875263249043 2601.1829729186647 3569.447204879833 1739.8592150508498 2804.0867919238726 1.0197630441681982 0.8265621728612464 0.7451230202621373 0.7408073573792495 1.2240272149095348 0.8392349099545251 0.9276399647865405 1.272944623240727 0.6204726686997942 1.0 11.453315288910883 -6.188527385070164 24.999999913902524 0.9846498679727732 0.8263180366499707 0.12978560344743983 0.18681486562598937 286.5360191797485 98246.08593475535 0.05306510365815125 0.06850674926479608 6.478472430307018e-07 6.188527385070164 -0.15833183132280249 S(ph)APAS(ph)PTHPGLMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 3 S(1)APAS(0.738)PT(0.269)HPGLMS(0.993)PR 77.137 0.026 10874000.0 312.49 605.71 397.69 505.96 395.81 493.74 417.67 586.66 336.31 486.16 True False 319.77040900030744 534.7931916130608 343.6858823548022 417.60358404548134 360.0090553859313 488.7734238800515 386.1648156319539 571.0998710597546 570.693506889448 548.5633715994171 0.5829233695789237 0.9748977407182559 0.6265199248588827 0.7612677142987085 0.6562761460654436 0.8910063069923184 0.7039566176393325 1.0410827638648732 1.0403419849661257 1.0 9.099514484261205 -7.765862762519889 24.994804128336654 1.0305343765133888 0.7500196553663635 0.574452668560659 0.1121591481470441 77.7189985659808 439147.5257500283 0.054858884874337877 0.02778341677093284 1.7144990052742577e-08 7.765862762519889 -0.28051472114702525 S(ph)APAS(ph)PTHPGLMSPR ddPTM_A459_Selumetinib_30min_R1 1 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 2 S(1)APAS(0.824)PT(0.176)HPGLMSPR 130.47 0.035014 0.0 1480.8 1219.7 1315.5 1253.1 1432.4 1278.4 1278.1 1403.1 687.19 1079.1 True False 1515.2997588647802 1076.896956976853 1136.8623255242585 1034.269608600269 1302.8396729107608 1265.540456694329 1181.6918879957866 1365.8852300888786 1166.1112396282 1217.6129963241128 1.2444838905624058 0.8844328700727805 0.9336811687756004 0.8494239234655474 1.0699948808397588 1.039361817354862 0.9704987476014386 1.1217728738214763 0.9577026880861219 1.0 10.249839947460043 S(ph)APAS(ph)PTHPGLMSPR ddPTM_A459_Selumetinib_30min_R2 3 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 2 S(1)APAS(0.998)PT(0.002)HPGLMSPR;S(1)APAS(0.997)PT(0.004)HPGLMSPR;S(1)APAS(0.835)PT(0.165)HPGLMSPR 139.21 0.007179000000000001 122278000.0 171146.0 154301.0 185019.0 223667.0 203391.0 161857.0 165199.0 164354.0 172603.0 185099.0 True False 161634.39047172118 166135.39054408582 173115.0789734562 193203.1687529044 177839.2042413899 184151.3325584435 172881.0808356082 164832.24292973077 207128.4229307665 179754.71092504152 0.8991941832285186 0.9242338611830039 0.9630628208995642 1.0748156071051231 0.9893437747817893 1.0244590064470431 0.9617610573093707 0.916984273076807 1.1522836974055157 1.0 17.455670055054853 -5.415839323119582 3.3083895431926362 1.0108833372976447 0.911115717070338 0.3224504071994526 0.06062145785777611 0.30307917032982984 6.1481641826601985 0.016149923801640674 0.037478143772683874 3.838492327661259e-06 5.415839323119582 -0.09976762022730667 S(ph)APASPT(ph)HPGLMSPR ddPTM_A459_Selumetinib_30min_R1 1 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 2 S(1)APAS(0.432)PT(0.568)HPGLMSPR 179.66 0.0034162 9757500.0 2841.7 3910.6 3293.7 4372.7 4030.3 3317.7 3778.3 3086.2 1643.5 2347.4 True False 2907.9060810143474 3452.7451340113803 2846.4336309990495 3609.09003074487 3665.7600766072596 3284.3269502305784 3493.29978907322 3004.3439506095797 2788.8994635092877 2648.71165561229 1.097856791943682 1.303556439107082 1.074648357803618 1.362583210255317 1.3839785349379086 1.2399714945458478 1.3188675262825806 1.134266141897231 1.0529267908796176 1.0 11.371075082065229 -8.063367730316811 2.648995298431732 1.0217027457608927 1.2578328307434627 0.4694156680241127 0.09738193764135342 0.259086119103068 3.3537058006858476 0.08025708220271667 0.026651590961608535 8.642358341736454e-09 8.063367730316811 0.23613008498257004 S(ph)APASPT(ph)HPGLMSPR ddPTM_A459_Selumetinib_30min_R2 1 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 2 S(1)APAS(0.004)PT(0.996)HPGLMSPR 228.49 1.5616e-11 39067000.0 74867.0 80084.0 84089.0 100070.0 88050.0 57608.0 54912.0 69678.0 69551.0 78414.0 True False 70706.19185634686 86226.18528935406 78678.80528918085 86440.29336962121 76988.37182301261 65542.97908664319 57465.516806063744 69880.75144418614 83463.14341730907 76149.98407596056 0.9285122343008838 1.1323204638275743 1.0332084273412028 1.1351321266646088 1.0110096903791306 0.8607090320762674 0.7546359661578022 0.9176725680530573 1.0960362556879006 1.0 16.216556114574097 -6.584762738796492 5.522627624202644 0.9109523426535242 1.0624752745985424 0.27752024174825873 0.09912488811545296 0.2395021636919642 14.433793616158447 0.03394493068772763 0.03410060748027781 2.601580455115094e-07 6.584762738796492 0.1515229319450182 S(ph)APASPTHPGLMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 2 S(0.907)APAS(0.086)PT(0.097)HPGLMS(0.91)PR 118.05 0.037674 17087000.0 70370.0 64169.0 74746.0 77265.0 89459.0 50533.0 58729.0 62870.0 61051.0 78306.0 True False 66459.11711342951 69090.55596414454 69936.92373729154 66741.37371044053 78220.36064639292 57493.462057098644 61460.01486930575 63052.94129131122 73262.90590746548 76045.10231657831 0.8739434242163023 0.9085470840254543 0.9196768970885433 0.8776551240945663 1.0286048445402693 0.7560442461863149 0.8082047758111449 0.8291519028907307 0.9634138646098409 1.0 16.214567713743563 -6.766842874232632 24.99999317419168 0.8567375971360087 0.9183978412818998 0.07860417857448088 0.07812806711732419 290.10373595419975 1342194.1328867828 0.026717887095787696 0.02423178419092083 1.7106341027806848e-07 6.766842874232632 0.06166024414589111 S(ph)APASPTHPGLMSPR ddPTM_A459_Selumetinib_30min_R2 1 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 S(0.941)APAS(0.021)PT(0.035)HPGLMS(0.003)PR 78.615 0.032645 22706000.0 3610.6 3255.1 4618.0 3715.8 5754.5 3735.6 4324.6 3451.8 3014.8 4890.7 True False 3409.9373063769876 3504.755703203833 4320.882907698233 3209.7016298874682 5031.568264117278 4250.144991599504 4525.702469032329 3461.8441665237483 3617.844240550142 4749.492783435354 0.7179582035095855 0.7379221030564046 0.9097567055513867 0.6757988223672718 1.059390653601098 0.8948629222940587 0.9528812181411179 0.728887130557921 0.7617327587417283 1.0 12.213557735390989 -5.0584325934764145 1.109568562401331 0.8746576815780106 0.6689132470281892 0.19392792997217823 0.11530712950970767 2.0191746400607067 2.839219347504794 0.03811922487230584 0.43592112428785856 8.741126524372607e-06 5.0584325934764145 -0.2057444345498214 S(ph)APGTPGTPR ddPTM_A459_Selumetinib_30min_R1 2 SAPGTPGTPR 10 0 Q16584;Q16584-2;E9PID4 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 S(1)APGTPGTPR;S(1)APGTPGTPR 143.4 0.0010944 7198300.0 2703.8 3557.2 3712.9 4106.6 3463.0 2838.7 3595.9 3245.3 2212.21 2887.9 True False 2766.7932793210375 3140.721370302587 3208.7085734998227 3389.4594004292308 3149.7722614423074 2810.1452553333775 3324.658367924302 3159.2241017799456 3753.9587965743117 3258.590095528131 0.8490768087455977 0.963828305564637 0.9846922992564293 1.0401613277720005 0.9666058537908289 0.8623807146501278 1.0202751099277074 0.9695064457832396 1.1520193355175268 1.0 11.670032168698716 -8.13892262584056 7.382917975148732 1.0753026024453138 0.9595643584823893 0.33933652546178517 0.06641876145819521 0.2895912581745277 15.890938305436286 0.04510720909051664 0.016867531553603734 7.262353324225274e-09 8.13892262584056 -0.11573824396292454 S(ph)APGTPGTPR ddPTM_A459_Selumetinib_30min_R2 1 SAPGTPGTPR 10 0 Q16584;Q16584-2;E9PID4 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 S(1)APGTPGTPR 132.32 0.0024604 4675700.0 29732.0 22716.0 32310.0 35115.0 36796.0 26079.0 24489.0 27969.0 27439.0 30654.0 True False 28079.61446662622 24458.244156547662 30231.209776468117 30332.27642324628 32173.35751958633 29671.145528408688 25627.78702403291 28050.385159482805 32927.5667097172 29768.939371343036 0.9432520962993045 0.8216028072566235 1.0155286152240306 1.018923652095094 1.0807693589029208 0.9967149033523012 0.8608901615320366 0.9422702236575283 1.1061047993337243 1.0 14.861520200689988 -5.2753562445433 24.845069894600773 0.998684769780611 0.8824274498724237 0.32147374559950836 0.06967432444113919 807.7859763381692 1442099.2394564052 0.019319227328648443 0.04056024654310843 5.3044914710531825e-06 5.2753562445433 -0.11625731990818733 S(ph)APPMEGAR ddPTM_A459_Selumetinib_30min_R1 1 SAPPMEGAR 9 0 Q86YD1 Q86YD1 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 S(1)APPMEGAR 119.22 0.0069649 24463000.0 1681.9 1868.6 1614.4 1738.8 1445.7 1622.9 1710.7 1808.3 1183.9 2357.3 True False 1721.0849975922972 1649.8234433114276 1395.1733472644326 1435.1512213184485 1314.936690259066 1606.575099475301 1581.6605217075291 1760.3380098137836 2008.9918313651615 2659.882417046457 0.6470530375938183 0.6202617953102595 0.52452444451046 0.539554384855871 0.4943589543026404 0.6040023006953998 0.5946355040249527 0.6618104614445587 0.7552934740611404 1.0 11.377146755917352 -8.5948086240496 0.9931783515339075 0.9993892556074123 0.5659779488414419 0.9029170415127742 0.04313173900855178 0.19348115945104424 0.4128905460385264 0.04487112191417827 0.01487066064414516 2.542092655824144e-09 8.5948086240496 -0.4334113067659704 S(ph)APPMEGAR ddPTM_A459_Selumetinib_30min_R2 2 SAPPMEGAR 9 0 Q86YD1 Q86YD1 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 S(1)APPMEGAR;S(1)APPMEGAR 112.85 0.0094578 27689000.0 44552.0 25686.4 35020.0 47204.0 36907.0 35618.7 36990.5 47100.0 38340.0 44605.0 True False 42075.978195786716 27656.46428520629 32766.851326893022 40774.73376855808 32270.412707233718 40524.85261063424 38710.63154528519 47237.05320217524 46009.07130910591 43317.13775229192 0.9713471475515592 0.6384647213617659 0.7564408228971528 0.941307202745654 0.7449802637416015 0.9355385584886678 0.8936562652558225 1.0904934086896338 1.0621447698647069 1.0 15.402650297311066 -7.339884502127585 1.2841776178703765 1.0584414742194275 0.8038877017677453 0.49132082608070915 0.09923762048510178 0.36591261882524695 1.1633369057247736 0.06489900682246509 0.035008244691864726 4.572097654952352e-08 7.339884502127585 -0.2545537724516822 S(ph)APPNLWAAQR ddPTM_A459_Selumetinib_30min_R1 5 SAPPNLWAAQR 11 0 Q92934;F5H3B1;F5H1R6 Q92934 BAD Bcl2-associated agonist of cell death 1 S(1)APPNLWAAQR;S(1)APPNLWAAQR;S(1)APPNLWAAQR;S(1)APPNLWAAQR;S(1)APPNLWAAQR 111.31 0.008318700000000002 55376700.0 4128.25 3706.2000000000003 4666.58 5138.23 4269.08 3752.1099999999997 4936.97 4594.74 2174.84 3339.73 True False 4224.430192823829 3272.2763810343654 4032.884067689086 4240.934587022714 3882.9424677672896 3714.367180043301 4564.57037812265 4472.872569381071 3690.5446359711227 3768.4168772250314 1.1210092541392593 0.8683424598830447 1.0701799188042067 1.1253889166703959 1.030390902671732 0.98565718737001 1.2112700178447047 1.186936773480004 0.979335555542026 1.0 11.879742855089928 -7.230879526582497 24.9957135247174 1.109963722640076 1.031691281809378 0.0788505286044886 0.09611740526361393 1436.7719688486436 1175176.1878807044 0.03674318727378251 0.02845683962952524 5.876523448556353e-08 7.230879526582497 -0.07827244083069806 S(ph)APPNLWAAQR ddPTM_A459_Selumetinib_30min_R2 2 SAPPNLWAAQR 11 0 Q92934;F5H3B1;F5H1R6 Q92934 BAD Bcl2-associated agonist of cell death 1 S(1)APPNLWAAQR;S(1)APPNLWAAQR 100.73 0.015978 28951000.0 6173.200000000001 7581.299999999999 9528.400000000001 4862.9 9754.5 14607.699999999999 15172.1 8167.099999999999 5667.7 9938.599999999999 True False 5830.118257277574 8162.761332278336 8915.353117737517 4200.564631029597 8529.052503663568 16619.778079502106 15877.63271294581 8190.864908863811 6801.398368769415 9651.646794416056 0.6040542491308923 0.8457376762896969 0.9237131556549997 0.43521740077142346 0.8836888341788509 1.7219629389170614 1.6450698053032553 0.8486494671150443 0.704687864531507 1.0 13.236559405223193 -6.535087304020156 24.95044339873887 1.2144712480630373 0.7196577248796999 0.3331868276195531 0.3216318948945902 275.7995224426908 563643.284362608 0.11521216250733829 0.11528702824663606 2.916840597368392e-07 6.535087304020156 -0.4948135231833374 S(ph)APSS(ph)PTLDCEK ddPTM_A459_Selumetinib_30min_R2 2 SAPSSPTLDCEK 12 0 A6NIZ0;Q9GZM8-3;Q9GZM8;Q9GZM8-2;J3QSD2;J3QRZ1 A6NIZ0 NDEL1 Nuclear distribution protein nudE-like 1 2 S(1)APS(0.009)S(0.982)PT(0.009)LDCEK;S(1)APS(0.164)S(0.829)PT(0.007)LDCEK 190.57 0.0024953 9931800.0 82132.0 69645.0 78235.0 78630.0 73092.0 61477.0 62646.0 71879.0 54445.0 75115.0 True False 77567.43224044611 74986.54755602915 73201.44527582744 67920.45835568415 63909.52950922927 69944.89871735814 65559.16313069405 72088.15598979102 65335.52132040353 72946.2347777918 1.0633507332726817 1.0279700903611069 1.0034986109812667 0.9311030043234291 0.8761182767542415 0.9588555040630088 0.8987326533082868 0.9882368323654448 0.8956668088411697 1.0 16.154545892886624 -5.558048042887985 2.437081835829057 0.931779923547503 1.0462516630411616 0.5797313411334707 0.03844378360139813 0.1928094993628564 2.2850490732114848 0.010505694575512025 0.023549202006061858 2.766635575404428e-06 5.558048042887985 0.11447173949365852 S(ph)APT(ph)SPTATNISSK ddPTM_A459_Selumetinib_30min_R2 2 SAPTSPTATNISSK 14 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 2 S(1)APT(0.947)S(0.053)PTATNISSK;S(1)APT(0.794)S(0.201)PT(0.002)AT(0.002)NISSK 167.61 0.014211 6126500.0 52302.0 42677.0 47531.0 49695.0 53161.0 40614.0 44135.0 44636.0 35858.0 44002.0 True False 49395.264221494814 45950.18867181652 44472.907207839904 42926.455271343366 46482.439914630086 46208.209842815675 46187.3649518434 44765.883370112395 43030.60195623158 42731.54792907407 1.1559437140793776 1.0753223531261904 1.0407511396885538 1.0045612048174057 1.087778050815799 1.0813605423213823 1.0808727319802527 1.0476073425754415 1.0069984365568474 1.0 15.383013958425488 -1.5228787452803376 0.11239275675644009 0.9850588789012288 1.338712293799005 0.3929232970029526 0.03576881095452799 143.04212325337818 1.1225554895780614 0.341602884768817 7.858758150401603 0.029999999999999995 1.5228787452803376 0.35365341489777624 S(ph)APTAPTPPPPPPPATPR ddPTM_A459_Selumetinib_30min_R1 1 SAPTAPTPPPPPPPATPR 18 0 A6NHN7;A6NHB5;Q14202-2;Q14202 A6NHN7 ZMYM3 Zinc finger MYM-type protein 3 1 S(0.76)APT(0.015)APT(0.226)PPPPPPPATPR 175.27 4.561699999999999e-09 9174900.0 1576.1 2087.3 2005.3 2169.0 1995.7 1657.8 1666.4 1843.6 664.24 1441.5 True False 1612.8200634432596 1842.9179456405566 1732.9912743244347 1790.2248671725988 1815.189287369452 1641.1240371619658 1540.7021063736634 1794.7017391432244 1127.1667658298804 1626.5305663990432 0.9915707068535841 1.1330361591178522 1.065452632815308 1.100640162659812 1.115988426450588 1.0089721466441488 0.9472321874556625 1.1033925683404113 0.692988369917512 1.0 10.667582218985775 -7.62515480892598 1.1286928359395354 0.8922670972254635 1.080259001496892 0.32765589898563563 0.10072899384483662 0.570134887501574 1.3327786552586025 0.07767474877423051 0.033360945232232896 2.370528554711269e-08 7.62515480892598 0.18799190427142853 S(ph)AQWLDQEEAPK ddPTM_A459_Selumetinib_30min_R2 1 SAQWLDQEEAPK 12 0 Q53H47-3;Q53H47 Q53H47-3 SETMAR Histone-lysine N-methyltransferase SETMAR;Histone-lysine N-methyltransferase;Transposon Hsmar1 transposase 1 S(1)AQWLDQEEAPK 107.69 0.0083758 2031800.0 14762.0 12481.0 13844.0 14126.0 13690.0 11780.0 12483.0 12356.0 11461.0 13238.0 True False 13941.587136968123 13438.252567259706 12953.292112207517 12202.01443129081 11970.139809847175 13402.588071806986 13063.48423459524 12391.953914354079 13753.52024709605 12855.784543545344 1.0844602357596247 1.0453078551325605 1.007584723307387 0.9491458409216433 0.9311092426371725 1.042533656846029 1.0161561272551178 0.9639204727163737 1.0698312654906341 1.0 13.650130035037618 -5.084217213960217 2.397724317931295 0.9940013784724702 1.0831960648974497 0.33776391187567834 0.039544233651088605 0.3926276609550794 3.97576279833105 0.010993567478200144 0.054857383542001 8.237260224092011e-06 5.084217213960217 0.08919468642497952 S(ph)AS(ph)PPPATSSSSSSR ddPTM_A459_Selumetinib_30min_R2 1 SASPPPATSSSSSSR 15 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 2 S(1)AS(0.999)PPPATSSSSSSR 121.42 0.030527 4445000.0 8766.5 8768.1 9368.0 10795.0 10966.0 8774.4 11375.0 8698.1 8205.6 10951.0 True False 8279.293025080004 9440.585076114874 8765.273079107199 9324.702377586318 9588.353042716148 9982.99395392726 11903.960039134894 8723.410030952024 9846.949283620228 10634.816175884958 0.7785083341500312 0.8877055249456901 0.824205414944825 0.8768089850702453 0.901600261268105 0.9387086517361963 1.1193385802123963 0.8202690001104904 0.925916266042166 1.0 13.37650747590105 -6.361012802612916 1.7367749485144406 0.9583958596435209 0.8371778189015786 0.37049929446428354 0.07413159820358875 0.4401079398850436 2.6336422894170113 0.027763925646721824 0.034246141810749885 4.3549903537426325e-07 6.361012802612916 -0.12121804074194231 S(ph)ASADNLTLPR ddPTM_A459_Selumetinib_30min_R1 1 SASADNLTLPR 11 0 Q8ND76-3;Q8ND76-2;Q8ND76 Q8ND76-3 CCNY Cyclin-Y 1 S(0.864)AS(0.136)ADNLTLPR 121.56 0.0044061000000000005 31746000.0 2170.3 1979.2 2896.4 1773.3 2615.6 1835.5 2475.2 2516.3 1027.3 2199.1 True False 2220.8637673313287 1747.4743438948822 2503.0847887863647 1463.6264439636573 2379.0194418216875 1817.0365365006567 2288.493671205048 2449.5595499056712 1743.2530689766288 2481.3759060479615 0.895013029633408 0.7042360408335109 1.008748727947866 0.5898447068806864 0.9587501176356246 0.7322697589155748 0.9222680310658319 0.9871779378268553 0.7025348576681691 1.0 11.276924591722755 -7.293137137618327 24.64637209532803 0.9019267142614527 0.8149166455031742 0.08879849526805694 0.13837249980027524 1482.6753302932868 1152837.377753183 0.05375629089462417 0.036245995579541695 5.091700645109148e-08 7.293137137618327 -0.08701006875827844 S(ph)ASADNLTLPR ddPTM_A459_Selumetinib_30min_R2 1 SASADNLTLPR 11 0 Q8ND76-3;Q8ND76-2;Q8ND76 Q8ND76-3 CCNY Cyclin-Y 1 S(0.826)AS(0.174)ADNLTLPR 113.07 0.0073098999999999985 28498000.0 47049.0 27002.0 34823.0 43544.0 33390.0 26447.0 47959.0 48449.0 32737.0 32524.0 True False 44434.20493206972 29072.966574885522 32582.52609241564 37613.232082410235 29195.24968961265 30089.834188037268 50189.188528955645 48589.97856883629 39285.314748205514 31584.947612499524 1.4068158502971584 0.9204690453049889 1.031583983996267 1.1908594101174022 0.9243406083111195 0.9526637358147596 1.589022376883526 1.5383903486231252 1.243798635672222 1.0 14.946949558883494 -7.251278791117797 24.98274832319171 1.3876687076692675 1.0612477670505287 0.2855086702247255 0.2053521670907297 735.5180850720012 1808486.8596087545 0.07685825312821527 0.05881575145851997 5.60687932317832e-08 7.251278791117797 -0.32642094061873883 S(ph)ASAPTLAETEK ddPTM_A459_Selumetinib_30min_R2 1 SASAPTLAETEK 12 0 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.591)AS(0.408)APT(0.002)LAETEK 131.79 0.0019749000000000004 19112000.0 88520.0 66199.0 72105.0 66878.0 65511.0 74207.0 91842.0 97815.0 73014.0 64627.0 True False 83600.41277363624 71276.25043666581 67465.84280198812 57769.10102901505 57280.92250422925 84428.34066592372 96112.83498147046 98099.62545585491 87618.84018161362 62761.05058888845 1.332042914980096 1.1356765026697138 1.0749635668771396 0.9204610261773215 0.9126826585399858 1.3452346618440987 1.531408956345399 1.563065381082435 1.3960703232256937 1.0 15.937581882057714 -6.902333387525452 6.1677020789353545 1.4219408823780078 1.0712501083926487 0.38043382149206173 0.1819958177288318 0.1959907447884649 10.434028304927082 0.0651323047951789 0.057386815847227074 1.252179566313885e-07 6.902333387525452 -0.3506907739853591 S(ph)ASAPTLAETEKETAEHLDLAGASSR ddPTM_A459_Selumetinib_30min_R1 1 SASAPTLAETEKETAEHLDLAGASSR 26 1 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.545)AS(0.45)APT(0.004)LAETEKETAEHLDLAGASSR 92.565 9.3602e-06 5093900.0 1456.5 1903.1 1358.1 1240.5 1359.7 1327.8 1593.5 1543.4 642.6 1244.8 True False 1490.4336161443482 1680.2841672728132 1173.6774795093077 1023.8699620689771 1236.7153750745324 1314.4435375459395 1473.3010120657896 1502.4640183302515 1090.4452663529462 1404.5822053787927 1.06112238246846 1.1962875229646444 0.8356061147683316 0.7289498315927021 0.8804862900431026 0.9358252813629059 1.0489247310864689 1.0696874932464788 0.776348484394241 1.0 10.455925347589698 -5.2602903196219275 24.999692912059807 0.9104056524561196 1.1287049608908486 0.3910094158830536 0.10943219297580015 107.53535189320425 2339543.991767002 0.030593687883021203 0.0721655175951999 5.4917363643849024e-06 5.2602903196219275 0.218299308434729 S(ph)ASAPTLAETEKETAEHLDLAGASSRPK ddPTM_A459_Selumetinib_30min_R1 1 SASAPTLAETEKETAEHLDLAGASSRPK 28 2 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.746)AS(0.2)APT(0.036)LAET(0.009)EKET(0.009)AEHLDLAGASSRPK 46.15 0.019322 9056500.0 2043.6 2138.9 2836.5 2987.2 2238.5 2232.8 2171.8 1755.1 1116.3 1505.3 True False 2091.2119038466117 1888.4765936523665 2451.318879779215 2465.5415966887936 2036.0280702392736 2210.340059220195 2007.9793774737896 1708.549046631738 1894.2795686738152 1698.5199178636701 1.231196574060111 1.1118365900752087 1.4432087925482706 1.4515823869700937 1.19870720903886 1.3013330229299116 1.1821936006492906 1.0059046282958413 1.1152530793141147 1.0 10.730062420886064 -7.531548861798879 2.950122308545537 1.0449471344675794 1.2916656926454908 0.5460354476399855 0.10139327375408741 0.2223375593990861 3.946672073071352 0.05659861623133425 0.031567881279469155 2.9407028212191874e-08 7.531548861798879 0.24671855817791144 S(ph)ASASPLTPCSVTR ddPTM_A459_Selumetinib_30min_R2 1 SASASPLTPCSVTR 14 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 S(0.467)AS(0.467)AS(0.057)PLT(0.007)PCS(0.001)VT(0.001)R 118.76 0.0023111 13125000.0 17911.0 12084.0 15884.0 19748.0 19064.0 13133.0 16990.0 14530.0 12440.0 17031.0 True False 16915.578323413894 13010.80394381589 14862.040733191581 17058.28833279986 16669.00988567761 14941.95154049585 17780.06866504632 14572.279894429006 14928.347602641561 16539.270778147813 1.0227523661903686 0.7866612814034195 0.898591052323042 1.0313809213002179 1.0078443063947664 0.9034226321657185 1.0750213176591732 0.8810714867600055 0.9026001087282123 1.0 14.013608006565166 -5.618548490865304 9.534015513318788 0.9695470900426042 0.8892950721803102 0.132196400132633 0.0789757661785385 0.5165686219088084 46.57359369717946 0.021005555334003303 0.036418414832111314 2.4068637672527412e-06 5.618548490865304 -0.08025201786229397 S(ph)ASDSGCDPASK ddPTM_A459_Selumetinib_30min_R1 2 SASDSGCDPASK 12 0 Q7LBC6;H0Y9V5 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 S(0.981)AS(0.013)DS(0.006)GCDPASK;S(0.985)AS(0.014)DSGCDPASK 166.62 0.00046292 12111000.0 6565.799999999999 7838.1 7925.299999999999 9333.6 7788.9 8261.8 8806.0 10279.9 6477.700000000001 7733.3 True False 6718.770365177186 6920.411608166166 6849.087790556748 7703.661973371222 7084.395370241979 8178.693793114208 8141.756330248729 10007.243658178793 10992.183787510867 8725.94438372094 0.7699762993804632 0.793084542353586 0.7849107774895239 0.8828456422141676 0.8118772087819602 0.9372846575062204 0.9330515955886599 1.146837891477768 1.2597127948715565 1.0 13.091095563145501 -7.435483953330458 1.3872414726099844 1.1573657673548412 0.8115459530168473 0.770498142811209 0.07456082685357843 0.191741380107999 0.707639393835232 0.049530542216932545 0.02496562131747259 3.6687324972534464e-08 7.435483953330458 -0.3458198143379939 S(ph)ASDSGCDPASK ddPTM_A459_Selumetinib_30min_R2 1 SASDSGCDPASK 12 0 Q7LBC6;H0Y9V5 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 S(0.97)AS(0.022)DS(0.009)GCDPASK 124.47 0.0030444 18608000.0 29991.0 24722.0 27963.0 39193.0 29398.0 30577.0 33745.0 37359.0 35165.0 47762.0 True False 28324.220283485367 26618.09790624103 26163.891023812386 33854.8457883039 25704.760418545462 34788.70419963007 35314.20936444897 37467.7085048846 42198.98259219378 46382.98695942081 0.6106596866705769 0.5738763208486005 0.5640837888836795 0.7298979217945272 0.5541851032800852 0.750031562867345 0.7613612593631454 0.8077899023118985 0.9097944172744309 1.0 15.501308108821574 -7.747179222658238 0.5534791007926493 1.0058669130860176 0.5824966802148154 0.8686428919502476 0.0524677481112372 0.2625875599806623 0.17609982805121638 0.049756464796977325 0.03069469691037014 1.7898670674603196e-08 7.747179222658238 -0.42337023287120223 S(ph)ASDSGCDPASKK ddPTM_A459_Selumetinib_30min_R1 1 SASDSGCDPASKK 13 1 Q7LBC6;H0Y9V5 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 S(0.843)AS(0.157)DSGCDPASKK 172.1 0.00033112 2930100.0 1239.2 1346.8 1319.3 1493.9 1071.3 1371.1 1473.4 1623.6 1105.2 1276.7 True False 1268.0709489365456 1189.1160298896666 1140.1463063961635 1233.018408976094 974.4011041533767 1357.3079788591947 1362.260251758854 1580.5368538039372 1875.4436793857392 1440.5768811111068 0.8802521861648172 0.8254443379464134 0.7914512035739298 0.8559198923316578 0.6763964609801512 0.9421975297925874 0.9456352310111713 1.0971555038318261 1.3018698994664017 1.0 10.492430941368118 -7.537482443957913 1.6826178658748658 1.1606034095501374 0.8150732490693454 0.6895842913002233 0.09220782603039547 0.20033665032559766 1.1038346795726486 0.05845752195294249 0.028174276545979832 2.900798459014512e-08 7.537482443957913 -0.345530160480792 S(ph)ASDSGCDPASKK ddPTM_A459_Selumetinib_30min_R2 1 SASDSGCDPASKK 13 1 Q7LBC6;H0Y9V5 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 S(0.865)AS(0.127)DS(0.009)GCDPASKK 76.82 0.022772 8764400.0 36890.0 37526.0 33271.0 40308.0 33527.0 34487.0 46435.0 64706.0 51306.0 99699.0 True False 34839.801482370545 40404.12353489206 31130.38008272582 34817.98086482162 29315.038524817115 39237.271208184 48594.31950920694 64894.28374734506 61568.63360941546 96820.43082088907 0.35983935608406564 0.4173098920581837 0.32152697337522507 0.3596139840488049 0.3027774022101581 0.4052581761464186 0.5019015005118391 0.6702540279684862 0.6359053878133745 1.0 16.563023893307992 -8.312770098460584 0.6655676865365449 0.9919984997701642 0.34244535868225995 0.9384350460078511 0.0510500952133998 0.1593112109776042 0.16314437406488963 0.0519033827119541 0.022343012770945685 4.866647621968717e-09 8.312770098460584 -0.6495531410879043 down S(ph)ASFFAVHSNPMDMPGR ddPTM_A459_Selumetinib_30min_R2 1 SASFFAVHSNPMDMPGR 17 0 J3KNG8;Q8TF40;Q8TF40-2 J3KNG8 FNIP1 Folliculin-interacting protein 1 1 S(0.5)AS(0.5)FFAVHSNPMDMPGR 83.42299999999999 0.021248 0.0 7766.6 5897.9 8748.7 9145.4 8402.3 7114.2 6753.3 6726.5 5681.0 7226.7 True False 7334.963464163165 6350.249965262475 8185.818166864336 7899.780743305034 7346.72795648495 8094.116473722342 7067.341831410084 6746.073001367978 6817.358740402466 7018.046393778451 1.045157448754637 0.9048458230330335 1.1663955618932818 1.1256381477198907 1.0468337688673415 1.15332900633114 1.0070240968591109 0.9612465667580112 0.9714040571812269 1.0 12.776853769571284 -7.507497692377206 21.49087968062316 0.9766221428154843 1.0721110995506486 0.28727968774302526 0.06964504974532684 150.0803299084728 209702.01643720103 0.03163355861033079 0.02047609996465584 3.108152417856775e-08 7.507497692377206 0.09548895673516433 S(ph)ASITNLSLDR ddPTM_A459_Selumetinib_30min_R2 1 SASITNLSLDR 11 0 Q9Y2I7;E9PDH4;Q9Y2I7-2;Q9Y2I7-3;Q9Y2I7-4 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 S(0.94)AS(0.004)IT(0.004)NLS(0.052)LDR 137.09 0.0013616 10571000.0 20826.0 19093.0 18448.0 27858.0 25591.0 26314.0 23949.0 17262.0 18379.0 24285.0 True False 19668.57429308345 20557.37170632878 17261.075764663692 24063.692342269518 22376.029793557278 29938.514645291067 25062.675954043203 17312.229562122062 22055.31355216634 23583.828949992356 0.8339856235723684 0.871672354388215 0.7319030256394938 1.0203471367306247 0.9487869777636142 1.2694509745967595 1.062705975657584 0.7340720456729599 0.9351879883004955 1.0 14.525510345480217 -5.774294390408905 24.97371990021762 0.9969445775798426 0.8184355330642479 0.2992079852450338 0.12842904145461426 306.5207386443498 595484.321093151 0.03971683015822037 0.05933409041894214 1.6815338318704792e-06 5.774294390408905 -0.17850904451559468 S(ph)ASLSHPGGEGEPAR ddPTM_A459_Selumetinib_30min_R1 1 SASLSHPGGEGEPAR 15 0 C9JXU1;A6NN40;Q2M3G4-2;Q2M3G4 C9JXU1 SHROOM1 Protein Shroom1 1 S(0.518)AS(0.146)LS(0.336)HPGGEGEPAR 141.65 0.00038462 6730200.0 1388.3 1655.8 1907.1 1777.7 1629.6 1804.7 1703.9 1752.9 1055.0 998.12 True False 1420.6446888384487 1461.9381662394635 1648.126294950447 1467.2580665618855 1482.2029677292471 1786.5463565364944 1575.37345118224 1706.407397778346 1790.2579458486748 1126.2384245121157 1.2614066949934417 1.2980716466611164 1.4633902192285901 1.3027952471054243 1.316064996069846 1.5862949777356627 1.398792135745758 1.5151386781334142 1.5895905404081832 1.0 10.137296562745485 -5.135814167201116 4.934348773340012 1.4153046353704521 1.2700910250685 0.06766497879651012 0.1635250818718532 0.49853893587417786 17.539276308660522 0.04002026838314972 0.11478489520553455 7.3145200179366364e-06 5.135814167201116 -0.14521361030195212 S(ph)ASNGHVPGTPVYR ddPTM_A459_Selumetinib_30min_R2 1 SASNGHVPGTPVYR 14 0 A0A087WX19;A0A087WX45;Q6IPM2-2;Q6IPM2-3;Q6IPM2-4;Q6IPM2;C9JP75 A0A087WX19 IQCE IQ domain-containing protein E 1 S(0.557)AS(0.442)NGHVPGTPVYR 86.49700000000001 0.023255 4283100.0 14766.0 11281.0 13795.0 16583.0 15469.0 12164.0 12156.0 15942.0 11905.0 13566.0 True False 13945.364832981391 12146.21642586785 12907.44471886035 14324.366792729406 13525.645925385379 13839.480586202051 12721.278086657041 15988.388580659825 14286.33265349258 13174.314331299009 1.058526803163528 0.9219619420352947 0.9797431877115121 1.0872950525173177 1.026667922538609 1.050489629909829 0.9656121576235916 1.2136030899669101 1.084408060581315 1.0 13.685440257041819 -6.377730197037299 0.7039478362290793 1.0840921955083465 0.9830039897395166 0.12581386702309882 0.07221871499321268 1.3472751646356458 1.4658782190275452 0.047282190034996056 0.0744002910071341 4.1905381905699745e-07 6.377730197037299 -0.10108820576882982 S(ph)ASPCIADK ddPTM_A459_Selumetinib_30min_R1 1 SASPCIADK 9 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 S(0.954)AS(0.046)PCIADK 144.55 0.0019369 10991000.0 6019.8 7228.2 7433.1 7742.2 7845.8 5402.5 7876.7 6876.5 3923.9 5902.8 True False 6160.049627508239 6381.918983700983 6423.725847095674 6390.17010909345 7136.148775288491 5348.155755077527 7282.55417743245 6694.112881980028 6658.571709683049 6660.481878141021 0.9248654587177623 0.9581767656550119 0.964453618315162 0.9594155837380618 1.0714162887686185 0.8029682916231022 1.0933974914537343 1.0050493349361673 0.9997132086697449 1.0 12.701410843047992 S(ph)ASPDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R1 1 SASPDDDLGSSNWEAADLGNEER 23 0 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 S(0.5)AS(0.5)PDDDLGSSNWEAADLGNEER 211.66 2.6774e-24 133110000.0 4069.0 4789.7 4991.4 5789.1 4901.3 4293.5 4914.3 4558.9 2357.8 4032.7 True False 4163.799783104262 4228.919697328881 4313.595295797629 4778.142359865791 4457.9782803947965 4250.3112881860925 4543.610394474374 4437.983162605795 4001.0143931014272 4550.336326824437 0.9150531925647948 0.9293642037840609 0.9479728499119485 1.0500635594117358 0.9797030285684192 0.9340653048281985 0.9985218823693507 0.9753088219971093 0.8792788281418382 1.0 12.15175746714034 -5.526394978035013 24.9990553860734 0.974479217595217 0.9263236397825305 0.19447749439299267 0.04219359636670285 166.25797582737496 1182025.1743939917 0.011677317855132777 0.020357715817725035 2.9758087879438875e-06 5.526394978035013 -0.048155577812686534 S(ph)ASPHDVDLCLVSPCEFEHR ddPTM_A459_Selumetinib_30min_R1 2 SASPHDVDLCLVSPCEFEHR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 S(0.883)AS(0.117)PHDVDLCLVSPCEFEHR;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHR 170.0 1.065e-09 41140000.0 7779.200000000001 10373.199999999999 7908.9 8607.3 9657.2 8534.2 11078.4 8613.300000000001 3426.18 7367.9 True False 7960.440224311788 9158.700921630154 6834.914820477998 7104.196634031678 8783.707965117143 8448.353696433622 10242.747368728991 8384.847304058549 5813.977221713567 8313.641734423529 0.957515428088599 1.1016472941945004 0.8221324708012491 0.8545228265750239 1.056541554917775 1.0162037247109534 1.232040987082447 1.008564907162187 0.6993297771829845 1.0 13.021264862897741 -4.503967769909701 17.645388890489023 0.9830033309022496 0.9025954465299694 0.0 0.1436683404854429 7096640.256700491 162188180.62183338 0.037095541679713726 15450910.979263145 3.1335182619907e-05 4.503967769909701 -0.08040788437228019 S(ph)ASPHDVDLCLVSPCEFEHR ddPTM_A459_Selumetinib_30min_R2 7 SASPHDVDLCLVSPCEFEHR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 S(0.5)AS(0.5)PHDVDLCLVSPCEFEHR;S(0.859)AS(0.141)PHDVDLCLVSPCEFEHR;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHR;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHR;S(0.565)AS(0.435)PHDVDLCLVSPCEFEHR;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHR;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHR 222.92 5.4904e-20 186045100.0 133752.5 113083.3 151848.9 168387.0 179289.0 132932.2 140869.0 147451.9 141556.3 148742.0 True False 126319.07150368023 121756.4254898804 142079.10709458162 145452.40011622265 156765.11295600375 151242.4039116348 147419.68762662803 147880.9606170237 169871.5154134892 144447.43198187236 0.8744985616603611 0.8429116656442907 0.9836042437390791 1.0069573278012751 1.0852744891697155 1.047041140410272 1.0205767288762093 1.0237700912230978 1.1760092449051462 1.0 17.140185030018465 -5.490739765787415 1.7602281638491322 1.0558919119395402 0.8502106314782808 0.7112905697434028 0.048605382737374456 0.2005298919510321 1.1856153286506625 0.014202265685079873 0.04237581613114924 3.2304292519733717e-06 5.490739765787415 -0.20568128046125944 S(ph)ASPHDVDLCLVSPCEFEHRK ddPTM_A459_Selumetinib_30min_R1 3 SASPHDVDLCLVSPCEFEHRK 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 S(0.5)AS(0.5)PHDVDLCLVSPCEFEHRK;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHRK;S(0.5)AS(0.5)PHDVDLCLVSPCEFEHRK 111.34 7.039399999999999e-05 9505100.0 3800.5 3629.3 5702.0 5989.299999999999 5623.6 4159.7 3878.2000000000003 4041.3 2210.9 2642.5 True False 3889.0442555143127 3204.379868784203 4927.6997188440255 4943.381188085224 5114.946372927217 4117.857194705414 3585.6642516432667 3934.1115960075476 3751.735822252926 2981.690615129709 1.3043084469530493 1.0746855668138482 1.6526529257730054 1.6579121800905483 1.7154517463927785 1.3810477766574987 1.2025608000537922 1.3194231406991255 1.2582579169065529 1.0 11.541914853760915 -8.252207109338423 0.7938455294165888 1.0252204425906744 1.4637297090040402 0.3439971063705597 0.1902865690409265 0.7897291739250138 1.0801026358981658 0.20504908389066492 0.07989827430571106 5.594907240818486e-09 8.252207109338423 0.43850926641336585 S(ph)ASPHDVDLCLVSPCEFEHRK ddPTM_A459_Selumetinib_30min_R2 1 SASPHDVDLCLVSPCEFEHRK 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 S(0.5)AS(0.5)PHDVDLCLVSPCEFEHRK 80.361 0.0013742 3909800.0 12699.0 13016.0 15375.0 18206.0 16316.0 10444.0 8152.1 9437.4 10836.0 18057.0 True False 11993.24041812479 14014.285346963563 14385.789239034279 15726.311392898235 14266.238213109318 11882.566198807486 8531.188803079702 9464.861271554319 13003.502783136968 17535.647492279673 0.6839348489073466 0.7991883592056442 0.8203739979015793 0.8968195442923892 0.8135563981535463 0.677623464091586 0.4865054915614427 0.5397497455238743 0.7415467714472449 1.0 14.098003081691617 -6.815751078686518 5.00435971950027 0.6449689872141054 0.8090452406652549 0.105792194645692 0.13981536920174992 0.2987796594011007 15.566477901028435 0.048668407362381455 0.04359189475765864 1.5284418527900373e-07 6.815751078686518 0.1640762534511494 S(ph)ASPPPATSSSSSSR ddPTM_A459_Selumetinib_30min_R2 1 SASPPPATSSSSSSR 15 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 S(0.514)AS(0.369)PPPAT(0.023)S(0.018)S(0.018)S(0.018)S(0.018)S(0.018)S(0.003)R 77.204 0.035323 801540.0 1118.2 2276.4 1097.1 2147.8 2410.8 825.49 504.91 2039.2 1122.9 2414.0 True False 1056.0549205092634 2450.9925602203325 1026.5137804321625 1855.2659348383413 2107.933751174548 939.1937544478728 528.3893154601848 2045.133734392267 1347.5113764474438 2344.301547674761 0.4504774232464809 1.0455107887683626 0.4378761688957333 0.7913938958401154 0.8991734673661506 0.4006283898841553 0.2253930668536552 0.8723850975659555 0.5748029206327991 1.0 11.194942440324155 -10.894697336808136 8.354562623632333 1.0000020320476386 0.6401554274215986 0.16324839315137163 0.24875160689145004 9.378713306963479e-06 7.05215898282109e-07 0.23991977087097238 0.0581887626180287 1.2743909045178982e-11 10.894697336808136 -0.35984660462604 S(ph)ASPSSQGWQGR ddPTM_A459_Selumetinib_30min_R1 2 SASPSSQGWQGR 12 0 Q5VV67-2;Q5VV67;X6R7H2 Q5VV67-2 PPRC1 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 1 S(0.977)AS(0.016)PS(0.007)SQGWQGR;S(0.867)AS(0.116)PS(0.017)SQGWQGR 119.21 0.0043318 16978400.0 3472.3 4078.4 4154.2 4327.700000000001 4065.7 3791.0 3832.1 3350.7 2357.51 2886.6000000000004 True False 3553.1978340803457 3600.899032003279 3590.0824573872087 3571.948435990256 3697.9581528576364 3752.8659819525956 3543.0416117585887 3261.828551392495 4000.522284282188 3257.123227865058 1.0909006462151434 1.1055458391003385 1.1022249409152367 1.0966574446529478 1.1353448715790626 1.1522026400003542 1.0877824889913488 1.0014446255785419 1.228237927892094 1.0 11.669382587406885 -10.664394273604444 4.042224707032039 0.9999657826120409 1.1083007977134143 0.27333071054304636 0.054190174605272826 6742012.691504037 8893554.126326472 1656.934904478979 0.012521136010250922 2.1657370508759455e-11 10.664394273604444 0.10833501510137333 S(ph)ASPTVPR ddPTM_A459_Selumetinib_30min_R1 1 SASPTVPR 8 0 K7EQ87;K7EKI0;Q92817 K7EQ87 EVPL Envoplakin 1 S(0.418)AS(0.291)PT(0.291)VPR 90.601 0.028038 31431000.0 5608.1 5947.4 6105.6 6099.8 6176.3 5541.2 5955.9 5367.0 3074.8 4688.4 True False 5738.757818536991 5251.07564312875 5276.493055660136 5034.584437427121 5617.65475551433 5485.460559007049 5506.641667877398 5224.649725527058 5217.711025493373 5290.201808883303 1.0847899618688408 0.9926040315345149 0.9974086521236019 0.9516809791590655 1.0618980066282477 1.0369095087820408 1.0409133463737903 0.9876087745374533 0.9862971610519276 1.0 12.369107043508336 -7.886479339310688 0.0033551519750965255 5.2295301680107436e-08 2.0186405102719642 0.058360119802214006 0.03737073728096783 36913.27156409921 125.65176971282769 37780.55148760569 37811.463206583125 1.2987353470900062e-08 7.886479339310688 2.0186404579766624 S(ph)ASPYHGFTIVNR ddPTM_A459_Selumetinib_30min_R2 1 SASPYHGFTIVNR 13 0 Q9NPI6-2;Q9NPI6;A0A087WT55;A0A087WXD0;A0A087WVE6 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 1 S(0.566)AS(0.428)PY(0.006)HGFTIVNR 70.563 0.040018 3763500.0 19179.0 14444.0 18287.0 24341.0 22497.0 19913.0 14625.0 15255.0 13988.0 18855.0 True False 18113.10795962007 15551.808355219866 17110.43432938015 21025.713809432935 19670.725734268213 22655.83499778373 15305.091478887722 15299.38952439879 16785.990857375407 18310.607158826668 0.9892139459115973 0.8493332973791141 0.9344547770024124 1.1482805363609936 1.0742803645801497 1.2373065950935678 0.8358593107334439 0.8355479090175164 0.9167358958538786 1.0 14.160392009598159 S(ph)ASTLCLPSVGAAR ddPTM_A459_Selumetinib_30min_R1 1 SASTLCLPSVGAAR 14 0 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.333)AS(0.333)T(0.333)LCLPSVGAAR 185.32 9.7342e-15 0.0 568.19 717.74 470.82 604.11 619.73 541.33 474.33 388.16 379.39 592.14 True False 581.4277214947185 633.7066671317264 406.88523002913803 498.6135290491652 563.6755309222182 535.8847116883145 438.5509062147261 377.86473587862565 643.7971204507385 668.1469369320359 0.8702093646713245 0.9484540482091399 0.6089756721739286 0.7462632865439363 0.8436400734103124 0.8020461998209008 0.6563689541531725 0.56554137270117 0.9635561952987381 1.0 9.38402160066549 -5.230701112062493 24.826531582868444 0.7561797994745266 0.9093317473297722 0.12945330099382424 0.13540311409397976 1093.0276014872131 882807.3662200057 0.033301884265019295 0.08808659523214463 5.878938106223697e-06 5.230701112062493 0.15315194785524555 S(ph)ASTLCLPSVGAAR ddPTM_A459_Selumetinib_30min_R2 3 SASTLCLPSVGAAR 14 0 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.793)AS(0.198)T(0.009)LCLPSVGAAR;S(0.986)AS(0.013)TLCLPSVGAAR;S(0.921)AS(0.04)T(0.04)LCLPSVGAAR 226.23 4.3778999999999995e-13 42821200.0 83933.0 52480.8 71556.6 83155.2 88474.7 79388.7 81823.3 81575.8 92996.9 79083.9 True False 79268.33987042034 56505.90860763106 66952.72626093544 71829.3183092788 77359.71721214645 90323.7728061343 85628.24557979313 81813.17207239938 111598.87855048996 76800.5423223511 1.0321325536701456 0.7357488228463495 0.8717741338325201 0.9352709777463961 1.0072808716304158 1.176082486853059 1.1149432411608495 1.0652681556467272 1.453100136742284 1.0 16.228828878034996 -6.469958876165471 1.52002375091102 1.1704566692164555 0.8671098171100995 0.4841536528104564 0.1304694597644912 0.32087630443535337 1.5047379644776342 0.050047135058686715 0.05766173773212979 3.3887624319383905e-07 6.469958876165471 -0.30334685210635604 S(ph)ASVSSISLTK ddPTM_A459_Selumetinib_30min_R1 1 SASVSSISLTK 11 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 S(0.938)AS(0.047)VS(0.012)S(0.003)ISLTK 151.26 0.00059911 12540000.0 853.11 1145.1 1179.6 1047.0 968.95 1035.9 985.49 1088.8 846.17 702.7 True False 872.9858031369068 1011.0311596574521 1019.4167990789929 864.1611046241184 881.3086435820165 1025.4797865219455 911.1536958774489 1059.9214870791618 1435.8886881884098 792.8983898776333 1.1010058972015737 1.275108100312176 1.2856840322709164 1.0898762258269725 1.111502627364431 1.2933306456584002 1.1491430774857112 1.33676836857083 1.810936567054964 1.0 9.630992185827347 -7.995562025477116 13.024099519998327 1.4615691965517505 1.194913248714556 0.16558892682778292 0.19706952477689826 0.4475047510501747 1296.628918691668 0.1028985067198214 0.04786646640240584 1.0102712043628436e-08 7.995562025477116 -0.2666559478371946 S(ph)ASWGSTDQLK ddPTM_A459_Selumetinib_30min_R2 1 SASWGSTDQLK 11 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 S(0.61)AS(0.39)WGSTDQLK 130.15 0.0024482 12419000.0 38416.0 35893.0 40136.0 45999.0 38873.0 30605.0 32743.0 34044.0 30263.0 32715.0 True False 36280.99251143255 38645.87768581462 37553.693456772664 39733.85684729903 33989.42621097071 34820.56094547136 34265.614379023624 34143.06240371241 36316.44561886991 31770.432946221958 1.1419735001045044 1.216410168260243 1.1820327887989464 1.2506551898287575 1.0698446026374542 1.0960052387203025 1.0785378479740984 1.074680425712379 1.1430894152542088 1.0 14.955397129818403 -6.2741987009684905 24.926021204481497 1.0817847993403953 1.1979755642716523 0.6675354558418495 0.041663170484492675 438.6038251571585 856834.5813119049 0.012198694724125847 0.013922961797472015 5.318648616475577e-07 6.2741987009684905 0.11619076493125702 S(ph)ATASPQQPQAQQR ddPTM_A459_Selumetinib_30min_R1 1 SATASPQQPQAQQR 14 0 Q9BX66-4;Q9BX66-9;Q9BX66-8;Q9BX66-10;Q9BX66-6;Q9BX66-5;Q9BX66-12;A0A0U1RQI5 Q9BX66-4 SORBS1 Sorbin and SH3 domain-containing protein 1 1 S(0.99)AT(0.01)ASPQQPQAQQR 180.3 7.3585e-05 1451000.0 582.54 628.52 712.79 788.75 698.63 603.53 557.91 521.43 497.39 478.02 True False 596.1120485744789 554.9325862089793 615.9970330752075 651.0096191712254 635.4390398531447 597.4590361613957 515.8263995240819 507.5999825566564 844.0345020717277 539.3785233091023 1.1051831372842114 1.028837008200572 1.1420496116457297 1.206962441102147 1.1780948117005259 1.1076804328358643 0.9563347023153101 0.9410830439493889 1.5648277890145728 1.0 9.075154268018053 -8.23143932000081 24.999541311634374 1.2824145170724113 1.0872878324713624 0.21753352051402874 0.1509169467155402 899.3416031982207 749438.210240134 0.09862320269299416 0.03726619974437091 5.8689536541648995e-09 8.23143932000081 -0.19512668460104887 S(ph)ATASPQQPQAQQR ddPTM_A459_Selumetinib_30min_R2 2 SATASPQQPQAQQR 14 0 Q9BX66-4;Q9BX66-9;Q9BX66-8;Q9BX66-10;Q9BX66-6;Q9BX66-5;Q9BX66-12;A0A0U1RQI5 Q9BX66-4 SORBS1 Sorbin and SH3 domain-containing protein 1 1 S(0.737)AT(0.036)AS(0.228)PQQPQAQQR;S(0.715)AT(0.022)AS(0.262)PQQPQAQQR 247.11 2.7061e-27 6604900.0 11587.7 11432.900000000001 13324.5 10029.0 14493.8 6669.5 8210.5 11464.5 7767.299999999999 11254.3 True False 10943.702023238418 12309.76666743237 12467.216176618678 8663.032899010015 12672.959267783996 7588.163085307015 8592.304518797098 11497.859796949857 9320.977036495 10929.359116816917 1.001312328222378 1.1263026986176556 1.1407088049138647 0.7926386905596574 1.1595336133007301 0.69429167842341 0.7861672790654476 1.0520159209754754 0.8528383903272871 1.0 13.415921185307838 -5.749145909053656 24.99646524858726 0.9043527111206157 1.0931274548259609 0.28197469840542233 0.1345704139658999 289.9146139459305 589481.8408762343 0.03618456627364993 0.06209429992615343 1.7817800457784675e-06 5.749145909053656 0.1887747437053452 S(ph)ATPVNCEQPDILVSSTPINEGQTVLDK ddPTM_A459_Selumetinib_30min_R1 1 SATPVNCEQPDILVSSTPINEGQTVLDK 28 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.5)AT(0.5)PVNCEQPDILVSSTPINEGQTVLDK 107.87 6.081299999999999e-10 16845000.0 1811.0 2354.8 1529.9 1692.3 1704.0 1670.0 2013.3 1871.0 1014.4 1681.4 True False 1853.1927764074264 2079.0989212831796 1322.1479831391587 1396.7715734053445 1549.8735008656338 1653.201316238681 1861.4351600828704 1821.375002135481 1721.3627111553506 1897.2240682229306 0.9767917282133434 1.0958636652921052 0.6968855209482835 0.7362185610019464 0.8169164237502801 0.871379055288489 0.9811361721899393 0.9600210289560078 0.9073059634794198 1.0 10.889674360366746 -7.202428480529286 6.1591227395454196 0.9586772505428797 0.8597915736885045 0.1578150412100544 0.1086308656329045 0.48895519879344046 39.37687205891864 0.046910823069578673 0.03596103257001194 6.274390139245769e-08 7.202428480529286 -0.09888567685437522 S(ph)ATPVNCEQPDILVSSTPINEGQTVLDK ddPTM_A459_Selumetinib_30min_R2 3 SATPVNCEQPDILVSSTPINEGQTVLDK 28 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.5)AT(0.5)PVNCEQPDILVSSTPINEGQTVLDK;S(0.776)AT(0.224)PVNCEQPDILVSSTPINEGQTVLDK;S(0.5)AT(0.5)PVNCEQPDILVSSTPINEGQTVLDK 100.37 4.1775e-07 31676600.0 28589.9 28519.1 34167.5 33398.6 29387.8 24748.9 26820.6 27151.3 22434.4 29754.5 True False 27000.987812437666 30706.42326664019 31969.200248761208 28849.65306420143 25695.8418337346 28157.83632685431 28067.811044010654 27230.305787860318 26921.906869509785 28895.410273524703 0.934438637722933 1.0626747630842543 1.1063764087839532 0.9984164540703823 0.889270703911005 0.9744743563185815 0.9713587998342998 0.9423747761356401 0.9317018382734945 1.0 14.818552733815878 -6.00265957051561 24.99178781812117 0.9501562020172206 1.039828095863429 0.3714929872460382 0.048673474329014164 105.83451702222152 994543.4691706075 0.01374264015795877 0.019982595381970492 9.938948253577675e-07 6.00265957051561 0.08967189384620833 S(ph)AVDLSCSR ddPTM_A459_Selumetinib_30min_R1 4 SAVDLSCSR 9 0 Q9Y446;Q9Y446-2;E9PK71;E9PQ15 Q9Y446 PKP3 Plakophilin-3 1 S(1)AVDLSCSR;S(1)AVDLSCSR;S(0.998)AVDLS(0.002)CSR;S(1)AVDLSCSR 177.57 0.00068248 94726800.0 8162.5 9213.599999999999 9219.9 9853.800000000001 7268.3 8480.6 8274.8 7503.999999999999 5697.900000000001 6873.0 True False 8352.670368539819 8134.867428713569 7967.888221285523 8133.018808734607 6610.88354832259 8395.292863768715 7650.625173920294 7304.969543572765 9668.920141849447 7755.216498689302 1.0770389672488823 1.0489542658271926 1.027423054228359 1.0487158946638249 0.8524434552458834 1.0825349447288275 0.9865134229603152 0.9419426968682779 1.2467634067319173 1.0 12.9209513415167 -10.115472430987248 7.245639215919366 0.9999861182776872 1.0272211194127288 0.006122955579600631 0.09703164789685456 0.0 0.0 0.09009488519348724 0.021851219292979094 7.665271977630033e-11 10.115472430987248 0.027235001135041514 S(ph)AVDLSCSR ddPTM_A459_Selumetinib_30min_R2 2 SAVDLSCSR 9 0 Q9Y446;Q9Y446-2;E9PK71;E9PQ15 Q9Y446 PKP3 Plakophilin-3 1 S(1)AVDLSCSR;S(1)AVDLSCSR 150.46 0.0013177 29387000.0 46124.0 33185.0 34490.0 42043.0 31411.0 41153.0 42386.0 36563.0 36076.0 34261.0 True False 43560.612729001325 35730.182793407046 32270.950949872662 36316.67087177965 27464.869362097113 46821.452200260814 44357.032986265614 36669.39227666951 43292.20804766051 33271.79590923154 1.30923539107533 1.073888012864776 0.9699191182198498 1.0915151971614276 0.8254699997867188 1.4072415065298536 1.3331721890599353 1.1021164104488654 1.3011683579018565 1.0 15.022012120113938 -6.773154243615462 24.99984781549722 1.241648946997261 1.05252249360756 0.23667370608856475 0.15603149168743777 316.18397542294497 674741.7038127996 0.05434368645537381 0.04831119293271309 1.6859541371756356e-07 6.773154243615462 -0.18912645338970102 S(ph)AVEAQNEVTENPK ddPTM_A459_Selumetinib_30min_R2 2 SAVEAQNEVTENPK 14 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 S(1)AVEAQNEVTENPK;S(1)AVEAQNEVTENPK 278.89 7.2745e-79 5674300.0 53000.0 133087.0 56630.0 69377.0 58248.0 49778.0 43594.0 51604.0 44091.6 111391.0 True False 50054.47217581019 143294.34495784756 52986.48745408205 59927.732917999674 50930.36549627304 56634.4676603063 45621.207379872234 51754.159096497926 52911.15202223716 108174.85240142484 0.46271819248769214 1.3246548691936106 0.4898225999648707 0.5539895048399468 0.4708152067291585 0.5235455968097104 0.4217357950309653 0.4784305959063757 0.4891261771810861 1.0 16.72300562672074 S(ph)AVEQLCLAESTRPR ddPTM_A459_Selumetinib_30min_R1 1 SAVEQLCLAESTRPR 15 1 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 S(1)AVEQLCLAESTRPR 145.52 0.0017148 4867100.0 1256.0 1569.1 1319.2 1386.8 1240.9 1592.8 1226.7 1072.9 876.57 1028.4 True False 1285.2623562494362 1385.3890425452003 1140.0598858469027 1144.6214134601025 1128.6608140986896 1576.7778781466884 1134.1690313781637 1044.443206729641 1487.475267860258 1160.4051574642926 1.1075979350677658 1.1938839065249764 0.982467096525279 0.9863980749286908 0.9726437415747354 1.358816675369015 0.9773905468125806 0.9000677048109207 1.2818585459501717 1.0 10.180412897437163 -10.399419716549867 0.006586256305438196 4.5390034360167215e-07 2.090320984265387 0.010132683956040167 0.1445785741149656 89550.64505369677 117.69256439708634 19378.865220298496 17986.775873948205 3.986394577835387e-11 10.399419716549867 2.0903205303650436 S(ph)AVFPGEGK ddPTM_A459_Selumetinib_30min_R1 4 SAVFPGEGK 9 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)AVFPGEGK;S(1)AVFPGEGK;S(1)AVFPGEGK;S(1)AVFPGEGK 129.82 0.0039921 100700000.0 19523.1 20741.4 20751.5 21015.5 19989.699999999997 18254.8 19911.9 19476.699999999997 11876.0 16140.599999999999 True False 19977.950244660307 18312.987245584733 17933.560279830217 17345.537434792892 18181.635164468178 18071.17328603225 18409.929351837352 18960.114646762224 20152.704611278554 18212.403232757828 1.096942011954077 1.005522830322908 0.9846893927526232 0.9524024486562134 0.9983105981184126 0.9922453975501953 1.010845692166767 1.0410550658498228 1.1065373610348574 1.0 14.15263368644507 -7.806803207791304 3.484768430301663 1.058616931388248 1.0016450972190885 0.17864324199109238 0.04211009453534782 0.3453311404797692 8.515125295948199 0.02535152671272794 0.011616599056374436 1.560259344243527e-08 7.806803207791304 -0.05697183416915963 S(ph)AVFPGEGK ddPTM_A459_Selumetinib_30min_R2 4 SAVFPGEGK 9 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)AVFPGEGK;S(1)AVFPGEGK;S(1)AVFPGEGK;S(1)AVFPGEGK 101.39 0.017063 99412300.0 474962.0 483490.0 451990.0 529545.0 553384.0 535642.0 521446.0 568563.0 444994.0 544912.0 True False 448565.5134635318 520572.12833461916 422909.45548950264 457420.0574839231 483862.95460427145 609421.8234260477 545694.2722256465 570217.4241993281 534005.2341712131 529178.974708594 0.8476631440441221 0.9837354717679129 0.799180382634039 0.8643957514294917 0.9143654183742334 1.1516365021146984 1.0312092851499761 1.0775511716302275 1.0091202781918476 1.0 19.013396216162562 -6.615841207928628 6.556722317683996 1.0567400675693754 0.8778822640618009 0.687242789203816 0.05846020551488094 0.12139074467295112 7.178409800424587 0.01891263829933619 0.018893146452156673 2.4219144148991286e-07 6.615841207928628 -0.17885780350757452 S(ph)AVLCYSPSDR ddPTM_A459_Selumetinib_30min_R2 1 SAVLCYSPSDR 11 0 Q86XL3;F5H1D4;Q86XL3-3 Q86XL3 ANKLE2 Ankyrin repeat and LEM domain-containing protein 2 1 S(0.934)AVLCYS(0.036)PS(0.029)DR 119.03 0.0051384 3039300.0 18930.0 15960.0 18927.0 19635.0 20175.0 12347.0 16377.0 21410.0 13122.0 16786.0 True False 17877.946382794093 17184.080680511568 17709.257426159467 16960.679127735733 17640.43613321159 14047.687175093452 17138.562950409854 21472.29955538369 15746.7666593137 16301.344564734258 1.0967160599421104 1.0541511230728162 1.0863678978034141 1.0404466368024547 1.0821460808438021 0.8617502144874425 1.0513588546239803 1.3172103362465015 0.9659796219128873 1.0 13.99270334504096 -10.043284006495181 7.529341844990111 0.9999110512357609 1.0635826947377833 0.028223890492803272 0.10831663631141426 0.0 0.0 0.1062416387891083 0.025767382268600706 9.051404914847862e-11 10.043284006495181 0.06367164350202248 S(ph)AVLLVDETATTPIFANR ddPTM_A459_Selumetinib_30min_R1 5 SAVLLVDETATTPIFANR 18 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR 283.22 3.045199999999998e-67 290118400.0 10490.68 13319.8 11899.84 12059.49 10788.39 10947.48 13196.099999999999 11591.060000000001 6359.12 10209.45 True False 10735.092432690151 11760.311623792977 10283.907089142214 9953.52645616381 9812.58202934496 10837.358290716546 12200.707552758931 11283.627435730894 10790.962188251395 11519.932355964427 0.9318711343936038 1.0208663784127252 0.8927055100126293 0.8640264672222999 0.8517916361083935 0.9407484311403548 1.059095416167269 0.9794872996705413 0.9367209680414825 1.0 13.491844624975405 -7.011105017739355 24.497816459028485 0.9932315932047835 0.9126960880571271 0.36059581636037885 0.0512956259874649 514.7686255160777 1135586.1693154597 0.020711686605545423 0.017072603524663284 9.747539017520792e-08 7.011105017739355 -0.0805355051476564 S(ph)AVLLVDETATTPIFANR ddPTM_A459_Selumetinib_30min_R2 5 SAVLLVDETATTPIFANR 18 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR;S(1)AVLLVDETATTPIFANR 188.16 2.0482e-10 59140700.0 33389.6 32550.800000000003 33861.3 48954.4 41630.200000000004 40066.0 39370.5 44174.2 30223.100000000002 35407.700000000004 True False 31533.9397011591 35047.341692681446 31682.700823395888 42286.72626894963 36400.24209728998 45584.72781706437 41201.30626116574 44302.73960856753 36268.56450397075 34385.38770074716 0.9170738447271862 1.019251025979268 0.9214001336593176 1.2297876829822914 1.0585962390210024 1.3257005625117282 1.198221367161449 1.2884176265258418 1.0547667753411043 1.0 15.069507991851568 -5.759677807432652 24.999999996488377 1.180725282984271 0.9592425683621889 0.4682509542120701 0.10275343746778479 37.2038520172426 527973.5457859935 0.02700271925568305 0.04384031833020088 1.7390905394774853e-06 5.759677807432652 -0.22148271462208202 S(ph)AVLLVDETATTPIFANRR ddPTM_A459_Selumetinib_30min_R1 2 SAVLLVDETATTPIFANRR 19 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(1)AVLLVDETATTPIFANRR;S(1)AVLLVDETATTPIFANRR 207.81 1.1217999999999998e-16 62608000.0 3206.29 3019.01 4475.2 5184.3 4328.43 3143.37 4162.349999999999 3509.43 1808.42 2161.72 True False 3280.990318645702 2665.542905700328 3867.492420513996 4278.9593263637225 3936.924270746383 3111.7505517516033 3848.3805883727905 3416.348516164791 3068.7566582290633 2439.197818935928 1.3451103855434718 1.0927948873220708 1.5855591500164365 1.7542485866236013 1.614024184583693 1.2757270146744675 1.5777238559731095 1.4006033006601875 1.2581007716576973 1.0 11.252191050104459 -8.541581745625134 1.8185804907192848 1.0019972462787783 1.465073908136509 0.3883493161991738 0.1799398399835287 0.4316776524490483 3.2233723556773928 0.18779928432217924 0.05330940813148556 2.873546665772549e-09 8.541581745625134 0.46307666185773066 S(ph)CETSSQDLGFSYYPAENLIEYK ddPTM_A459_Selumetinib_30min_R1 1 SCETSSQDLGFSYYPAENLIEYK 23 0 S5FZ81;Q8WUB8-2;Q8WUB8;Q8WUB8-3 S5FZ81 PHF10 PHD finger protein 10 1 S(0.972)CET(0.026)S(0.003)SQDLGFSYYPAENLIEYK 101.87 2.5518e-05 4337600.0 1130.8 1148.7 983.69 1039.3 960.83 857.67 1360.6 1335.5 763.06 1450.0 True False 1157.1454398462276 1014.2096699838587 850.1103010223927 857.8057650772163 873.9230961483146 849.042618502053 1257.9688465746556 1300.0782016846265 1294.857088302644 1636.1216241960549 0.7072490349944596 0.619886477255145 0.5195886958832376 0.5242921750995855 0.534143112115969 0.518936126719338 0.7688724529833085 0.7946097542249948 0.791418601865189 1.0 10.676064282393165 -7.960877237774644 0.9301609111282595 0.9611028908227165 0.5662358811252203 0.7691752349433667 0.07401810773100145 0.2730234378646683 0.4434217466852338 0.07327623397462422 0.028329056062210586 1.0942656391414966e-08 7.960877237774644 -0.3948670096974962 S(ph)CFESS(ph)PDPELK ddPTM_A459_Selumetinib_30min_R2 1 SCFESSPDPELK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(1)CFES(0.204)S(0.796)PDPELK 188.96 0.0023063000000000003 2040800.0 14456.0 14872.0 16136.0 18002.0 17875.0 14685.0 13931.0 15275.0 11028.0 15018.0 True False 13652.59339195306 16012.634578982956 15097.82732754844 15550.096544817869 15629.382695472474 16707.725452842566 14578.819103752801 15319.447721087616 13233.908148065208 14584.391318549933 0.9361099201026157 1.097929576163829 1.035204486617516 1.0662149832087715 1.0716513534297047 1.1455894927607955 0.9996179329890823 1.050400211190354 0.9074021574855139 1.0 13.83213755597862 -8.239749070873009 21.90138117032033 0.9537011630633249 1.0541454315347374 0.31463326779305756 0.056830270994063604 157.4137898420011 158947.4068062013 0.037070042209616044 0.013960534143639899 5.757725143551546e-09 8.239749070873009 0.10044426847141252 S(ph)CGPASQSTLGLK ddPTM_A459_Selumetinib_30min_R2 1 SCGPASQSTLGLK 13 0 Q9BXS6-4;Q9BXS6-6;Q9BXS6-3;Q9BXS6-5;Q9BXS6-2;Q9BXS6;Q9BXS6-7;H0YMD2 Q9BXS6-4 NUSAP1 Nucleolar and spindle-associated protein 1 1 S(1)CGPASQSTLGLK 141.85 0.0012657 0.0 6835.3 6633.5 9887.1 10172.0 9133.6 6393.0 8022.6 6095.4 6168.2 7951.8 True False 6455.421389873876 7142.268119935683 9250.974750260537 8786.556052321263 7986.155512579993 7273.57772012411 8395.666796480316 6113.136604852211 7402.01235390785 7722.2108727424 0.8359550776656469 0.9248993892599101 1.1979697139473768 1.1378290747453883 1.0341799316526379 0.9419035351388991 1.0872102477951047 0.7916303641007986 0.9585353826629138 1.0 12.914798235588568 -7.7444294048728155 24.999201990020318 0.9063120816982952 1.027562402345543 0.15739811262860381 0.1113760294968779 403.9835191005539 593727.8808166815 0.05567062394183533 0.032038984633173256 1.801235903861505e-08 7.7444294048728155 0.12125032064724772 S(ph)CHDLSVL ddPTM_A459_Selumetinib_30min_R1 1 SCHDLSVL 8 0 P55042;Q8IYK8;P55040 P55042;P55040 RRAD;REM2;GEM GTP-binding protein RAD;GTP-binding protein REM 2;GTP-binding protein GEM 1 S(0.999)CHDLS(0.001)VL 87.696 0.032109 1643400.0 2641.2 2242.8 1870.3 2742.1 2110.9 1873.9 2120.1 1939.8 985.84 1839.2 True False 2702.7348211194326 1980.2119333505684 1616.3235328225162 2263.2437105919716 1919.9694677096647 1855.0502673650665 1960.1791500976963 1888.350202641586 1672.8984770952197 2075.279235325094 1.3023475468331602 0.9541905974115175 0.7788462898436499 1.0905731007506723 0.9251619902653246 0.8938798383314772 0.9445375430601429 0.909925840580087 0.8061076546323941 1.0 11.019089753321687 -4.767757344735973 4.919103188948062 0.9185252274008882 1.325951289959764 0.651845969700217 0.08359377050580277 0.10172856616245089 6.291600014808392 0.020266267277992085 0.14279747143577717 1.7070359022678433e-05 4.767757344735973 0.4074260625588759 S(ph)CHDLSVL ddPTM_A459_Selumetinib_30min_R2 2 SCHDLSVL 8 0 P55042;Q8IYK8;P55040 P55042;P55040 RRAD;REM2;GEM GTP-binding protein RAD;GTP-binding protein REM 2;GTP-binding protein GEM 1 S(0.999)CHDLS(0.001)VL;S(0.999)CHDLS(0.001)VL 101.72 0.016803 3712400.0 37107.0 33780.0 34249.0 34781.0 40472.0 32042.0 30102.0 29504.0 30573.0 30474.0 True False 35044.74149109038 36370.81738018047 32045.45662749172 30043.76779942841 35387.54553572933 36455.494651684174 31501.802645981403 29589.851755349875 36688.454280993625 29594.1364390392 1.184178547101006 1.2289872845284917 1.082831279551001 1.0151932583441117 1.1957620594411986 1.2318485699617776 1.0644609519480925 0.9998552184924148 1.2397203870627538 1.0 14.853023738907087 -14.522878745278774 0.11324044855492556 0.6004420963173995 1.2015656036428828 0.1760169408014376 0.08738896369717324 310.432446088712 2.3100130933115754 29.12542820817097 1.0517502138397772 3.0000000000107993e-15 14.522878745278774 0.6011235073254833 S(ph)CMLTGTPESVQSAK ddPTM_A459_Selumetinib_30min_R2 1 SCMLTGTPESVQSAK 15 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4 FUBP1 Far upstream element-binding protein 1 1 S(0.571)CMLT(0.11)GT(0.127)PES(0.191)VQSAK 217.19 3.2952e-09 15770000.0 47143.0 43937.0 51689.0 51997.0 49899.0 37049.0 42197.0 42558.0 32040.0 45862.0 True False 44522.98078838153 47306.82662027796 48363.38601472799 44914.91890017188 43630.24151728007 42152.16345266355 44159.244111769265 42681.83673414385 38448.89527239836 44537.84489621366 0.9996662589340196 1.0621714348890667 1.085894167700053 1.0084663729203087 0.9796217490754531 0.9464347354680172 0.9914993465596136 0.9583273917632329 0.8632859394520693 1.0 15.44274413002434 -6.2172678411391535 2.1376810476096706 0.9524847081434639 1.0500292361141705 0.5178787014161936 0.04048968909726755 0.25647056486685726 2.3007995473593494 0.013669649287408273 0.018207174911242945 6.063622542665225e-07 6.2172678411391535 0.09754452797070667 S(ph)CPELTSGPR ddPTM_A459_Selumetinib_30min_R1 3 SCPELTSGPR 10 0 Q13111;Q13111-3;Q13111-2 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(1)CPELTSGPR;S(0.999)CPELT(0.001)SGPR;S(1)CPELTSGPR 181.4 0.00013582 54498000.0 3064.3500000000004 3618.65 2852.92 2894.68 2816.44 2667.29 3425.3999999999996 2991.05 1876.25 2422.87 True False 3135.7433928128635 3194.976775735255 2465.5091339678183 2389.1784778732967 2561.6934992828697 2640.459484305551 3167.0193201946395 2911.7176377003384 3183.8592141218737 2733.8689652523435 1.1469984233583872 1.168664927377143 0.9018388098715058 0.8739184314390757 0.9370213173499405 0.9658324952168399 1.1584385939661577 1.0650538393421423 1.1645983236903217 1.0 11.416728380674462 -7.252180504099689 24.735781187718796 1.1024438432438923 0.9938303027571187 0.18573498257076948 0.09988563448061533 1016.58014581399 2715875.0336547443 0.04261403967245905 0.03251948247293907 5.595249999956782e-08 7.252180504099689 -0.10861354048677363 S(ph)CPELTSGPR ddPTM_A459_Selumetinib_30min_R2 4 SCPELTSGPR 10 0 Q13111;Q13111-3;Q13111-2 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(1)CPELTSGPR;S(1)CPELTSGPR;S(1)CPELTSGPR;S(1)CPELTSGPR 199.68 5.9036e-05 90280000.0 52444.8 57283.100000000006 63629.0 55772.7 57629.5 54406.8 40606.4 43993.799999999996 35763.4 50632.799999999996 True False 49530.1279691685 61676.529575802735 59535.17941401708 48176.36204672609 50389.56699573321 61900.84284424344 42494.67806005513 44121.81467443431 42917.079312886766 49170.89950418666 1.0073057127000749 1.2543299023958527 1.2107807669645734 0.9797738608101751 1.024784323732837 1.2588918134184812 0.8642241343670541 0.8973155894916577 0.872814606721453 1.0 15.585517126783623 -7.278648599847782 24.934771382902113 0.9000315291598898 1.1216940024336979 0.5255817398356211 0.09949547115719719 657.9510024822712 953313.7963578851 0.04257486710166278 0.02878388321674079 5.26443054320481e-08 7.278648599847782 0.22166247327380806 S(ph)CPETLTHAVGMSESPIGPK ddPTM_A459_Selumetinib_30min_R2 2 SCPETLTHAVGMSESPIGPK 20 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 S(0.957)CPET(0.022)LT(0.022)HAVGMSESPIGPK;S(0.975)CPET(0.023)LT(0.001)HAVGMSESPIGPK 126.3 0.00014221 10722300.0 55837.0 54442.0 70797.0 85592.0 90659.0 64209.0 64723.0 69410.0 64918.0 82376.0 True False 52733.803073221046 58617.526341379074 66241.99809794543 73934.22194556445 79269.60591825673 73053.20691873126 67732.74774619144 69611.97160855596 77903.41396047309 79997.59084144815 0.6591923896525487 0.7327411453871971 0.8280499125184191 0.9242056062925564 0.9908999144157445 0.9131925868057655 0.8466848443028101 0.8701758500018326 0.9738220006509242 1.0 16.287668932881566 -5.318373342491639 1.7568918235238853 0.9244525125562346 0.6633188386013288 0.7971437479036125 0.04777827701730829 0.19785873509117127 1.0825389760624888 0.01482234955543621 0.05957958805872818 4.804261711506064e-06 5.318373342491639 -0.26113367395490583 S(ph)CSPELQQK ddPTM_A459_Selumetinib_30min_R2 1 SCSPELQQK 9 0 P16152 P16152 CBR1 Carbonyl reductase [NADPH] 1 1 S(0.772)CS(0.228)PELQQK 118.23 0.0072794 10214000.0 76198.0 60759.0 77880.0 76658.0 75204.0 51808.0 57815.0 63866.0 49576.0 53484.0 True False 71963.22020476208 65419.01992902272 72869.28558933282 66217.04815757392 65756.20118770975 58944.08173380106 60503.512058249136 64051.83948641454 59492.585269176656 51939.777951879376 1.3855126656766577 1.2595167424402824 1.4029572027982868 1.2748812330103145 1.2660085156434606 1.1348543266475062 1.1648781424191648 1.233194326432366 1.1454147017011649 1.0 15.664552225902943 -1.5228787846127099 0.06008602954963077 0.6438351741421531 2.45526472792485 0.781214578107227 0.053644365980090314 160.90206116006652 0.7250197736229443 4.429888604292418 25.522268186081742 0.029999997283016097 1.5228787846127099 1.8114295537826968 S(ph)CSVTDAVAEQGHLPPPSAPAGR ddPTM_A459_Selumetinib_30min_R1 2 SCSVTDAVAEQGHLPPPSAPAGR 23 0 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5 A0A1B0GVY1 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 S(0.823)CS(0.165)VT(0.012)DAVAEQGHLPPPSAPAGR;S(0.496)CS(0.496)VT(0.008)DAVAEQGHLPPPSAPAGR 143.21 7.828399999999998e-07 30845000.0 1706.44 1598.98 2020.87 2127.27 1952.19 1844.58 2161.43 1790.6100000000001 1323.29 1447.21 True False 1746.1967318457696 1411.770678254366 1746.446953844323 1755.7822283034836 1775.6147591871388 1826.0251999446373 1998.3915949227237 1743.1172060790036 2245.5264807223643 1632.9735005191542 1.0693356207498894 0.8645398579986365 1.0694888516495176 1.0752055852377802 1.087350626708049 1.1182209627799276 1.2237746627776849 1.0674497813496866 1.3751150768879394 1.0 10.673285664061511 -6.0951908026589905 0.8915523188982224 1.1709338300617422 0.9677638977201288 0.2913790508672226 0.10656032286496486 0.7327001659662987 1.2057995848814869 0.047625694647098746 0.09588409556158586 8.031731790713006e-07 6.0951908026589905 -0.2031699323416134 S(ph)CSVTDAVAEQGHLPPPSAPAGR ddPTM_A459_Selumetinib_30min_R2 4 SCSVTDAVAEQGHLPPPSAPAGR 23 0 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5 A0A1B0GVY1 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 S(0.482)CS(0.482)VT(0.036)DAVAEQGHLPPPSAPAGR;S(0.439)CS(0.439)VT(0.122)DAVAEQGHLPPPSAPAGR;S(0.536)CS(0.422)VT(0.042)DAVAEQGHLPPPSAPAGR;S(0.549)CS(0.438)VT(0.013)DAVAEQGHLPPPSAPAGR 167.27 2.2155e-12 31996000.0 89704.5 75833.7 79383.6 92807.6 84999.2 74060.6 91106.9 82270.3 72087.5 82073.1 True False 84719.0830055653 81649.90094622254 74276.14560232862 80167.04477796015 74320.84059351079 84261.77539481052 95343.55137489749 82509.69295241863 86507.01429304027 79703.4363514771 1.0629288633424807 1.0244213384497238 0.9319064397021083 1.005816667984535 0.9324672058776728 1.0571912486085546 1.1962288671526087 1.035208727871738 1.0853611619900638 1.0 16.28235430577726 -6.9821109220588 18.09303944543071 1.0885015535539888 0.9912201210309329 0.327387075639183 0.05976221886889898 10.539728469328022 10658.206739446863 0.02087276820026543 0.0183870922007613 1.0420512477201077e-07 6.9821109220588 -0.09728143252305588 S(ph)CTLPNYTK ddPTM_A459_Selumetinib_30min_R2 1 SCTLPNYTK 9 0 A0A2R8YCU7;J3KTL8;A6NHR9-3;A6NHR9-2;A6NHR9 A0A2R8YCU7 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 S(0.997)CT(0.003)LPNYTK 112.13 0.0065275 0.0 14866.0 13734.0 15234.0 18136.0 18824.0 9285.7 10311.0 13702.0 13650.0 12162.0 True False 14039.80723331311 14787.353638229686 14253.861025525088 15665.845513654975 16459.160831304845 10564.720887807984 10790.481930858896 13741.870551511787 16380.381412866349 11810.851459329098 1.1887210064117277 1.252014191284196 1.2068444916616334 1.326394254266987 1.3935625969035588 0.8944927403572731 0.913607453960126 1.1634953329852797 1.3868925089162722 1.0 13.527825353757189 -6.75150782700699 24.99995216500875 1.0720354150330664 1.2715479022014387 0.33883863163345096 0.14093759768946718 270.06712207619887 679818.7716304022 0.0504598776777485 0.04987630470787148 1.772116107151272e-07 6.75150782700699 0.19951248716837222 S(ph)CTPSPDQISHR ddPTM_A459_Selumetinib_30min_R2 2 SCTPSPDQISHR 12 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 S(0.507)CT(0.335)PS(0.158)PDQISHR;S(0.948)CT(0.044)PS(0.007)PDQISHR 147.51 0.00041529 57454400.0 60050.0 60397.0 50824.0 77408.0 78138.0 55480.0 63180.0 56865.0 47052.0 67768.0 True False 56712.66139919626 65029.25569303615 47554.03917298722 66864.89686375177 68321.60587741698 63121.866402703825 66117.99518879491 57030.4677354925 56463.71474272431 65811.3617575904 0.8617457515632588 0.9881159416297286 0.7225809936610609 1.0160084076369966 1.0381430204874473 0.9591332669153227 1.004659278018497 0.8665748012563323 0.8579630208945194 1.0 16.006049053727608 -4.730105454140116 23.580505066146834 0.936457363892067 0.8617447842358787 0.05884736084660447 0.09237334776169599 7111.18737305249 5350948.905829408 0.023509399530629818 2.852983436286745 1.8616350448966585e-05 4.730105454140116 -0.07471257965618827 S(ph)DAEEDGGTVSQEEEDR ddPTM_A459_Selumetinib_30min_R2 1 SDAEEDGGTVSQEEEDR 17 0 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 S(1)DAEEDGGTVSQEEEDR 165.9 7.2117999999999984e-06 0.0 2486.6 998.66 2926.3 2302.2 2633.4 2100.2 4430.5 3799.8 3273.7 2502.6 True False 2348.404726648484 1075.2540108019853 2738.025043914536 1988.6363884834852 2302.5687491053004 2389.4834862825987 4636.527028869198 3810.8567889092487 3928.5314748205533 2430.343435464313 0.9662851317142448 0.4424288333539822 1.126600053293061 0.8182532392190733 0.9474252550094421 0.9831875822217249 1.9077661869559588 1.5680322103041338 1.6164511638537267 1.0 11.246944482292152 -7.120327327300226 5.635535864214014 1.5674307881202914 0.8601349372508255 0.5833544401154861 0.2662469523911116 0.1500309952445256 6.324213278562975 0.09844788523005961 0.07608232042868968 7.580060513037398e-08 7.120327327300226 -0.7072958508694659 S(ph)DASDMNSDTSPSCR ddPTM_A459_Selumetinib_30min_R2 1 SDASDMNSDTSPSCR 15 0 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 S(0.999)DAS(0.001)DMNSDTSPSCR 169.15 6.1281e-05 3936500.0 6626.9 9548.9 7937.9 8249.8 9414.8 5805.2 5367.4 7244.9 7154.0 7891.6 True False 6258.60342758258 10281.269925447166 7427.184156132043 7126.163008301214 8232.028654620095 6604.813605641249 5616.9947353013295 7265.981459542237 8584.999899461229 7663.749003160783 0.8166503658981166 1.341545752764976 0.9691319683184858 0.9298533922969228 1.0741516523081502 0.8618254072409216 0.732930414733663 0.9480975246639087 1.1202089076665338 1.0 12.903834596541902 -5.494969682917249 24.82907620519491 0.9429688918607695 1.0981582668465444 0.08951378669691801 0.1553249496736644 1241.160375402989 1104186.4069581148 0.03989102862422223 0.08271673761983374 3.1991184248770293e-06 5.494969682917249 0.1551893749857749 S(ph)DDEQSSADK ddPTM_A459_Selumetinib_30min_R1 2 SDDEQSSADK 10 0 P27540-3;P27540-4;P27540;A6NGV6 P27540-3 ARNT Aryl hydrocarbon receptor nuclear translocator 1 S(1)DDEQSSADK;S(1)DDEQSSADK 88.819 0.031713 30209000.0 402.49 375.88 412.4 497.72 399.99 387.62 436.23 460.53000000000003 315.69 405.55999999999995 True False 411.8672338907926 331.871794858129 356.39834515104815 410.80254536152415 363.81097512397014 383.72089473080047 403.3248198892122 448.3152483877356 535.7028729146617 457.61757648893274 0.9000249445199214 0.7252164512657332 0.7788126231634538 0.8976983544063221 0.795010930120532 0.8385186986804485 0.8813577987622738 0.9796722665843188 1.1706343908921457 1.0 8.83799865497328 -7.814365978094219 2.1587670946384936 1.0851078368938436 0.8199211794119559 0.7271045712777886 0.06395274203241146 0.15650538554434734 1.4237739753157814 0.044561986661339675 0.01782512039427847 1.5333243124008254e-08 7.814365978094219 -0.26518665748188774 S(ph)DDEQSSADKER ddPTM_A459_Selumetinib_30min_R1 1 SDDEQSSADKER 12 1 P27540-3;P27540-4;P27540;A6NGV6 P27540-3 ARNT Aryl hydrocarbon receptor nuclear translocator 1 S(1)DDEQSSADKER 98.582 0.0083326 4532600.0 864.16 1349.1 902.37 914.13 1320.2 1420.4 1927.0 1927.6 1558.9 1768.9 True False 884.2932466373501 1191.1467448204257 779.8331103636067 754.4943558453155 1200.7881431002409 1406.1120656200126 1781.6448385633998 1876.473786272771 2645.339442448814 1995.955545545104 0.4430425560384141 0.5967801975745499 0.390706652813067 0.3780116032791 0.6016106650172414 0.7044806527672425 0.8926275149463937 0.9401380659308711 1.325349879837309 1.0 10.962863873605885 -7.275370384859735 1.0828124739497673 1.1355170261708007 0.45942790688043483 0.8647081229082463 0.10749648406716322 0.1758085533371531 0.39979296605851206 0.07563101515815177 0.042464040670889734 5.3043187634320254e-08 7.275370384859735 -0.676089119290366 down S(ph)DDTLDEEDSFVMK ddPTM_A459_Selumetinib_30min_R1 2 SDDTLDEEDSFVMK 14 0 P53355-4;P53355;P53355-3 P53355-4 DAPK1 Death-associated protein kinase 1 1 S(1)DDTLDEEDSFVMK;S(1)DDTLDEEDSFVMK 281.51 1.1189e-54 5768100.0 1416.6 1663.8600000000001 1278.99 1319.45 1559.24 1458.3000000000002 1455.3600000000001 1317.94 548.55 1403.92 True False 1449.6040237762331 1469.0544976924716 1105.3101829891827 1089.0328266440233 1418.2070173061813 1443.6308260304595 1345.5810234829419 1282.9839499275445 930.849285493166 1584.1268073388464 0.9150807984945369 0.927359155142584 0.6977409749450416 0.6874656887307369 0.8952610426993585 0.9113101421821121 0.849414969337818 0.8098997782146066 0.5876103359786502 1.0 10.629472110607688 -10.774181169923462 5.2477939833652 1.000022090376087 0.8124082473067109 0.21277655627839798 0.1100321096856125 2.974439708479893e-05 4.243581209381832e-06 0.11143183026621198 0.027023008320397512 1.681972264554679e-11 10.774181169923462 -0.18761384306937612 S(ph)DDTLDEEDSFVMK ddPTM_A459_Selumetinib_30min_R2 4 SDDTLDEEDSFVMK 14 0 P53355-4;P53355;P53355-3 P53355-4 DAPK1 Death-associated protein kinase 1 1 S(1)DDTLDEEDSFVMK;S(1)DDTLDEEDSFVMK;S(0.99)DDT(0.01)LDEEDSFVMK;S(0.998)DDT(0.002)LDEEDSFVMK 150.59 0.00014717 1199500.0 14432.5 13141.3 14939.6 16778.7 14838.800000000001 11682.5 14897.2 16361.199999999999 11805.099999999999 13227.900000000001 True False 13630.399427875114 14149.19545406056 13978.402401006602 14493.412115128076 12974.617283444868 13291.658331823865 15589.949318241781 16408.80838325752 14166.449862053358 12845.976156788303 1.061063734006099 1.1014496120315143 1.0881541605244132 1.1282452916175782 1.010014118435724 1.0346943019040282 1.2136056558071266 1.277350057557633 1.1027927881188901 1.0 13.649028903345869 -7.260002806340095 24.96641992069797 1.1715496304506576 1.0726694014227909 0.17897355144417038 0.07535148668815071 169.78304527253724 2950712.7929645926 0.029312449947366995 0.021478478810384585 5.495373228256179e-08 7.260002806340095 -0.09888022902786675 S(ph)DEDRYQNGAER ddPTM_A459_Selumetinib_30min_R2 1 SDEDRYQNGAER 12 1 Q9HCG8 Q9HCG8 CWC22 Pre-mRNA-splicing factor CWC22 homolog 1 S(1)DEDRYQNGAER 89.266 0.014306 7324800.0 9678.5 7224.4 11853.0 11702.0 13913.0 7817.1 8715.8 9208.4 7021.7 9944.5 True False 9140.60771610526 7778.488249892715 11090.39088457062 10108.167412924038 12165.124556201881 8893.83456843144 9121.10197003006 9235.194919467316 8426.236202690377 9657.376446086024 0.946489739437443 0.8054452773294561 1.1483854798955644 1.0466784089192995 1.2596717777458293 0.9209369250627033 0.9444699625152019 0.9562840354235326 0.8725181471107915 1.0 13.237415599779483 S(ph)DEEDFVKVEDLPLK ddPTM_A459_Selumetinib_30min_R1 1 SDEEDFVKVEDLPLK 15 1 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 S(1)DEEDFVKVEDLPLK 63.292 0.040042 2666700.0 728.88 929.28 795.76 795.2 732.43 789.36 931.09 1191.0 575.19 1163.4 True False 745.8614858464083 820.4794655894483 687.7001627967951 656.3332477527206 666.1818358210188 781.4197550815356 860.8571316751402 1159.4108110867755 976.0554197845494 1312.7337224756495 0.568174240576229 0.6250159126270696 0.5238687412553703 0.4999743942853538 0.5074767444571198 0.5952614316998552 0.6557743714023532 0.8832033421829627 0.7435288688583641 1.0 10.358358591431456 -7.826614338288461 0.962326089389609 0.9442667369118163 0.5402829423772881 0.8257335510189836 0.06648697856310018 0.2171211163106141 0.3667535823181826 0.05996815374197428 0.024045809582626792 1.490684245920896e-08 7.826614338288461 -0.40398379453452815 S(ph)DEMNVK ddPTM_A459_Selumetinib_30min_R1 1 SDEMNVK 7 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3 P60660-2 MYL6 Myosin light polypeptide 6 1 S(1)DEMNVK 95.775 0.023573 3030800.0 1260.6 1795.8 1487.1 1584.1 1633.0 1590.0 1525.6 1443.0 793.74 1199.2 True False 1289.9695272993938 1585.5469011552286 1285.159988055586 1307.4666722397953 1485.2954383295669 1574.0060436044926 1410.5227637323933 1404.7269524754136 1346.9188075241009 1353.1290011971796 0.9533233905696312 1.1717632980687114 0.9497690071815339 0.9662542677623608 1.0976746762618 1.1632342830667972 1.0424155882287902 1.0381323223673298 0.9954104939975537 1.0 10.402083670551367 -4.500209249120789 17.708488645774768 1.048721810963236 0.7129020910051397 0.1306667501885196 0.07253210813748946 3732004.918687286 76579859.15950944 0.018536207431605424 35625005.73522405 3.160754397810247e-05 4.500209249120789 -0.33581971995809623 S(ph)DGAPASDSKPGSSEAAPSSK ddPTM_A459_Selumetinib_30min_R2 1 SDGAPASDSKPGSSEAAPSSK 21 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 S(1)DGAPASDSKPGSSEAAPSSK 116.92 4.1915e-05 13037000.0 22286.0 15264.0 17965.0 14354.0 14147.0 11733.0 28145.0 21753.0 13885.0 13256.0 True False 21047.433337926534 16434.699718504286 16809.15145881306 12398.960437968877 12369.727384215335 13349.114248430507 29453.798268259467 21816.297628597 16662.387979314954 12873.264836775732 1.6349724490868256 1.27665358608598 1.30574113652921 0.9631558579101174 0.9608850234229692 1.0369641592624887 2.2879820031447853 1.6946981131214853 1.2943404948614616 1.0 13.652090366790585 S(ph)DHEEDNMEDGM ddPTM_A459_Selumetinib_30min_R2 2 SDHEEDNMEDGM 12 0 A0A1B0GVV8;A0A1B0GWI0;A0JP08;A0A1B0GV02;O60315-2;O60315 A0A1B0GVV8 ZEB2 Zinc finger E-box-binding homeobox 2 1 S(1)DHEEDNMEDGM;S(1)DHEEDNMEDGM 126.5 0.0026822 0.0 21191.8 17758.6 23245.0 22146.0 22483.0 17881.3 17671.4 19044.300000000003 16010.5 21440.0 True False 20014.04459349688 19120.62751710103 21749.442007242407 19129.67659601914 19658.48453942981 20344.286764720055 18493.15511521479 19099.715760046405 19213.047370747005 20820.97149219009 0.9612445125821394 0.918335031786252 1.04459304482505 0.9187696454603307 0.9441674970259517 0.9771055482378026 0.8881984744156411 0.9173306714919943 0.922773818596975 1.0 14.345749764914268 -7.238838068448272 24.900005069508065 0.9251866203179833 0.9599323201358927 0.08892088314079982 0.042626298896222485 1554.197024713848 1712270.2055002102 0.01576260413732583 0.012201808060420805 5.769815573122935e-08 7.238838068448272 0.034745699817909426 S(ph)DIDVNAAASAK ddPTM_A459_Selumetinib_30min_R2 1 SDIDVNAAASAK 12 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(1)DIDVNAAASAK 118.2 0.0045795 3826300.0 18059.0 17908.0 22451.0 21973.0 23756.0 14816.0 20424.0 15055.0 10597.0 15205.0 True False 17055.353075904848 19281.486016704323 21006.527102800566 18980.239494460777 20771.558898665407 16856.769513742966 21373.75646938823 15098.807557510587 12716.696104919014 14765.992142665582 1.155042811286908 1.3058036216199418 1.422628896171716 1.28540224802222 1.4067161012937996 1.1415941002051728 1.4474988380651952 1.022539319514017 0.8612151477566325 1.0 13.849990675487293 -7.899178591285775 5.518980307311894 0.9343298327532592 1.3089171212821737 0.7124317561725827 0.10224099462981126 0.10172276362534831 4.598168947896579 0.0551205665454284 0.025796270744448603 1.2613087504870678e-08 7.899178591285775 0.37458728852891454 S(ph)DISPLTPR ddPTM_A459_Selumetinib_30min_R1 4 SDISPLTPR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.963)DIS(0.037)PLTPR;S(0.969)DIS(0.031)PLTPR;S(1)DISPLTPR;S(1)DISPLTPR 157.78 0.00086299 32675200.0 8179.5 9170.6 7099.5 6587.099999999999 8496.0 6921.0 8596.0 9064.9 4701.1900000000005 8412.8 True False 8370.066435463576 8096.901888703721 6135.426894762042 5436.786640181017 7727.538300090625 6851.381023765212 7947.5967993207 8824.469405055006 7977.576068667609 9492.664827611425 0.881740437218163 0.8529640554833632 0.6463334591690054 0.5727355530732501 0.8140536340873897 0.7217552866542302 0.8372355859656428 0.9296092894154621 0.8403937370108276 1.0 13.212597429221551 -7.494312870845547 2.8815384507366275 0.9142550032497517 0.7432017196459975 0.40873772012041487 0.09415877049488183 0.30461306906619595 5.076240215970905 0.0518712843298803 0.029724455200858348 3.203960322242534e-08 7.494312870845547 -0.17105328360375427 S(ph)DISPLTPR ddPTM_A459_Selumetinib_30min_R2 3 SDISPLTPR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.993)DIS(0.007)PLTPR;S(0.999)DIS(0.001)PLTPR;S(1)DISPLTPR 128.81 0.0042342 35334000.0 102356.0 73810.0 94149.0 119703.0 122436.0 96543.0 131513.0 139174.0 115015.0 75874.0 True False 96667.46328353274 79470.9896634436 88091.5558416807 103399.24490080705 107054.49508827245 109840.92191990347 137628.61508806556 139578.97329850384 138021.2137876062 73683.3204756731 1.3119314202927101 1.078547887777144 1.1955426991209572 1.4032924172431236 1.4528999832956362 1.4907162328028902 1.867839481168663 1.894308948041864 1.8731676707372946 1.0 16.169050456258923 -6.4572949528616785 1.2040179473169266 1.717100263206526 1.190321451666437 0.3242837280794326 0.25716754140386694 0.4476827520350887 1.3530092527101587 0.11004704190519338 0.1326245126772272 3.4890327591727006e-07 6.4572949528616785 -0.5267788115400889 S(ph)DKSPDLAPTPAPQSTPR ddPTM_A459_Selumetinib_30min_R1 3 SDKSPDLAPTPAPQSTPR 18 1 F8WAE5;Q9BY44-4;Q9BY44-3;Q9BY44;Q9BY44-2 F8WAE5 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 S(0.691)DKS(0.309)PDLAPTPAPQSTPR;S(0.579)DKS(0.421)PDLAPTPAPQSTPR;S(0.944)DKS(0.056)PDLAPTPAPQSTPR 173.34 1.6879000000000002e-07 57748200.0 7424.26 8498.699999999999 10152.8 10565.7 7656.5 8612.300000000001 8270.7 7736.6 4845.12 7433.84 True False 7597.230812904802 7503.668253061555 8774.10552533842 8720.598837752668 6963.970926864868 8525.66808134275 7646.83444022123 7531.400235981486 8221.814766436337 8388.045775733523 0.9057211913272416 0.8945669174540681 1.0460249931780012 1.039646071434328 0.8302256703237744 1.0164069569109133 0.9116348008428131 0.8978730490205122 0.9801823912575574 1.0 13.03411901927775 S(ph)DKSPDLAPTPAPQSTPR ddPTM_A459_Selumetinib_30min_R2 2 SDKSPDLAPTPAPQSTPR 18 1 F8WAE5;Q9BY44-4;Q9BY44-3;Q9BY44;Q9BY44-2 F8WAE5 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 S(0.561)DKS(0.439)PDLAPTPAPQSTPR;S(0.626)DKS(0.374)PDLAPTPAPQSTPR 132.01 0.00027752 600392100.0 407253.0 305417.0 384242.0 339182.0 309193.0 227594.0 329817.0 294451.0 229978.0 293105.0 True False 384619.5086229286 328841.5018295617 359520.2880510569 292984.82647841354 270349.4111195089 258943.0076073717 345154.14401998714 295307.80366101273 275980.0261222109 284642.297071753 1.351238071712066 1.1552798203657937 1.2630599589365616 1.029308818445059 0.949786500111608 0.9097137364026295 1.2125890901343457 1.037469858481964 0.9695678715403336 1.0 18.118790532793135 -5.771712008168909 10.60550270339173 1.0180357335863712 1.2464701786359287 0.6124364010536204 0.08774277688765006 0.16828292006079157 163.0163305951816 0.02530422566542063 0.03910606082580742 1.6915622782203658e-06 5.771712008168909 0.22843444504955746 S(ph)DLEEDNER ddPTM_A459_Selumetinib_30min_R2 2 SDLEEDNER 9 0 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 S(1)DLEEDNER;S(1)DLEEDNER 167.84 0.00081147 12687600.0 15386.3 9912.8 14756.400000000001 15787.1 19534.3 17339.6 33805.0 36222.0 27586.0 13984.6 True False 14531.191042239036 10673.079885324243 13806.989289553532 13636.869745733471 17080.226595142267 19727.972506783055 35376.9994833367 36327.40002312508 33103.97081724035 13580.82826164558 1.0699782636437154 0.7858931487607953 1.016652962805418 1.0041265144517113 1.2576719376814112 1.452633972443197 2.6049220858824182 2.6749031298569204 2.437551685321817 1.0 13.729283848272742 -7.027242577282037 2.7550502311040366 2.3148501112610713 1.0088230800397884 0.5743065849203608 0.4593344440956697 0.17277160372571074 2.6274989869433902 0.18064705262360387 0.14259344274814634 9.391985701291497e-08 7.027242577282037 -1.306027031221283 S(ph)DNALHLASER ddPTM_A459_Selumetinib_30min_R2 1 SDNALHLASER 11 0 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 S(1)DNALHLASER 68.809 0.046902 1875600.0 18116.0 10863.0 17783.0 20145.0 24355.0 18373.0 17794.0 20663.0 26366.0 13506.0 True False 17109.18524409392 11696.157169949698 16638.861140666446 17401.216247936667 21295.307163537465 20903.713976511855 18621.456258142083 20723.125909056194 31639.936727592234 13116.046687197724 1.3044468087166696 0.8917440940009806 1.2685881300580655 1.326711978306817 1.6236071486634256 1.5937511107607978 1.4197461096504074 1.5799826276376072 2.412307418703782 1.0 13.679045321744445 -5.988590386861818 1.5271367515024292 1.6348376882953575 1.0979580150284194 0.2647648333320667 0.34056002555414194 0.5034226361177294 2.375892077858647 0.11473287859910823 0.20123580554914983 1.0266197457986288e-06 5.988590386861818 -0.5368796732669381 S(ph)DSDLLTCSPTEDATMGSR ddPTM_A459_Selumetinib_30min_R1 2 SDSDLLTCSPTEDATMGSR 19 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(1)DSDLLTCSPTEDATMGSR;S(0.888)DS(0.112)DLLTCSPTEDATMGSR 218.36 3.9576999999999996e-19 8394200.0 1350.24 1695.96 1294.1599999999999 1185.99 1245.35 980.88 1888.15 1759.21 750.89 1693.5 True False 1381.6979648903157 1497.3962147695865 1118.4201803120284 978.8791102895491 1132.7083123843997 971.0132377677819 1745.7253253417148 1712.5500360805777 1274.2054871642756 1910.8772210869104 0.7230699856814471 0.7836171776216292 0.5852914922895303 0.5122668790477082 0.5927687555666781 0.5081505117400833 0.9135727330240209 0.8962114452892354 0.6668170372764741 1.0 10.900019368985026 -7.269680510831498 24.97440546410929 0.8605012678196795 0.6177017584831151 0.5491934096436955 0.11157318482776811 531.1528886706059 1609629.684056791 0.04856435393854945 0.03336692815843976 5.3742700969826305e-08 7.269680510831498 -0.24279950933656436 S(ph)DSDLLTCSPTEDATMGSR ddPTM_A459_Selumetinib_30min_R2 2 SDSDLLTCSPTEDATMGSR 19 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(1)DSDLLTCSPTEDATMGSR;S(1)DSDLLTCSPTEDATMGSR 355.72 8.888399999999992e-195 11439500.0 18699.8 14852.5 18973.5 19742.1 21431.4 15463.8 19452.1 20299.4 17628.8 13161.4 True False 17660.539977230474 15991.638991685342 17752.76566678483 17053.191922977938 18738.995932853086 17593.798083600064 20356.661193604923 20358.467893253415 21155.052589826984 12781.396184576055 1.3817379355271315 1.2511652687038406 1.3889535548712568 1.3342198048407943 1.4661149425495754 1.3765161356027265 1.5926789921566094 1.592820346013606 1.6551441082278504 1.0 13.641757818224422 -6.448629627606226 1.3457241054785554 1.497545063846309 1.3283564479366567 0.04734295466846039 0.1776035036878977 0.8591930136814645 3.1920263999152363 0.07048594593592758 0.08405338996427125 3.5593473528011253e-07 6.448629627606226 -0.16918861590965228 S(ph)DSDSSTLAK ddPTM_A459_Selumetinib_30min_R2 1 SDSDSSTLAK 10 0 Q6AWC2-3;Q6AWC2-2;Q6AWC2-4;Q6AWC2;Q6AWC2-6;Q6AWC2-7 Q6AWC2-3 WWC2 Protein WWC2 1 S(0.579)DS(0.337)DS(0.033)S(0.033)T(0.019)LAK 139.15 0.0015585999999999998 19367000.0 96460.0 65743.0 82459.0 88770.0 89240.0 71287.0 97711.0 127830.0 75190.0 125060.0 True False 91099.13935997462 70785.27670293687 77153.6777145711 76679.37286320869 78028.87338427779 81106.1371710446 102254.75511067326 128201.96413660413 90230.10098413324 121449.19285509737 0.7501008217375821 0.5828385931505672 0.6352753435473562 0.6313699668197537 0.6424816135038054 0.6678194828994327 0.8419549995089284 1.0556016151508194 0.7429452502972824 1.0 16.889993376367627 -7.340274975826135 3.2356149189415264 0.9279544164612156 0.6443316430117506 0.6959630745804767 0.08499999208759493 0.134325921138489 2.7356498244308076 0.03619473073824492 0.023473771243274846 4.5679887343399707e-08 7.340274975826135 -0.28362277344946496 S(ph)DSEATISR ddPTM_A459_Selumetinib_30min_R1 2 SDSEATISR 9 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;H0Y4T4 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 S(0.999)DS(0.001)EATISR;S(0.999)DS(0.001)EATISR 172.21 0.00051016 99388000.0 3847.8 4327.3 4520.3 4591.5 3854.7000000000003 3732.6000000000004 4283.299999999999 3593.5 2479.9 3259.3 True False 3937.4462534845366 3820.6577042928097 3906.4680882305624 3789.68071812955 3506.0430656025605 3695.053432929641 3960.2072324953847 3498.1887066669433 4208.209175270264 3677.6629032704836 1.070638162617632 1.0388819760764814 1.062214833435823 1.0304589675033704 0.9533345382157499 1.0047286905071404 1.0768271417626774 0.9511988452111974 1.144261800484208 1.0 11.844573532202086 -5.901891775179497 5.633789957538019 1.0187493052209062 1.0549481799902793 0.07747419496391916 0.0539384298161294 0.5432919722887731 25.858738744683556 0.014721400003961299 0.02212200631486552 1.2534534926980075e-06 5.901891775179497 0.03619887476937311 S(ph)DSEATISR ddPTM_A459_Selumetinib_30min_R2 2 SDSEATISR 9 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;H0Y4T4 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 S(0.991)DS(0.008)EAT(0.001)ISR;S(0.98)DS(0.02)EATISR 127.83 0.0044695 206396000.0 46516.0 45202.0 48868.0 39100.0 50728.0 35043.0 45628.0 34518.0 33725.0 44573.0 True False 43930.82693830165 48668.8480526619 45723.886083455414 33774.512548737825 44355.09512592606 39869.85516131851 47749.79241016674 34618.44166523747 40470.94235523203 43286.061675437915 1.0148954475853738 1.1243538027918667 1.0563189237749668 0.7802630047977479 1.0246969442150649 0.9210783706835154 1.1031216646180058 0.7997595605904068 0.9349647620678948 1.0 15.401614924387477 -5.5552145316606385 24.98141521121294 0.9375726942993001 1.0748027821784714 0.27768420707277774 0.09431655190556792 217.099399544761 167721.8653894949 0.024730757453528273 0.0428352829276195 2.784745227598194e-06 5.5552145316606385 0.13723008787917124 S(ph)DSELEVKPAESLLR ddPTM_A459_Selumetinib_30min_R1 2 SDSELEVKPAESLLR 15 1 Q92539 Q92539 LPIN2 Phosphatidate phosphatase LPIN2 1 S(0.999)DS(0.001)ELEVKPAESLLR;S(0.998)DS(0.002)ELEVKPAESLLR 153.72 0.00095908 12887400.0 2698.7 3356.8 3456.9 3069.7 2983.1 2825.0 3359.7 3179.08 1816.1 2928.9 True False 2761.5744592439096 2963.7842954660164 2987.4719673924783 2533.634520405592 2713.279131709081 2796.5830648947745 3106.2751240900106 3094.76047129282 3081.789057304055 3304.852844901948 0.8356119285322802 0.8967976592476538 0.9039652013556185 0.7666406461376838 0.8209984707472145 0.8462050191459421 0.9399132941370558 0.9364291290811282 0.9325041694543252 1.0 11.690370318980026 -7.278049005983148 4.912261124312528 0.9481032503782487 0.8450607077201819 0.6318901264842947 0.040064613397329016 0.14564059033708723 10.281258315665104 0.01805566162448233 0.01256797390968209 5.271703719264493e-08 7.278049005983148 -0.10304254265806678 S(ph)DSELEVKPAESLLR ddPTM_A459_Selumetinib_30min_R2 1 SDSELEVKPAESLLR 15 1 Q92539 Q92539 LPIN2 Phosphatidate phosphatase LPIN2 1 S(0.994)DS(0.006)ELEVKPAESLLR 118.21 0.0097389 2930000.0 24938.0 20841.0 25405.0 24852.0 28213.0 18913.0 20836.0 17711.0 19860.0 22093.0 True False 23552.045794723672 22439.437685622903 23770.469958872574 21467.114727908764 24668.630712579852 21518.094074879922 21804.915285750736 17762.53607778611 23832.55493476379 21455.117685492325 1.0977355678011154 1.0458780983893723 1.107916083580649 1.0005591692663867 1.1497783919992415 1.0029352618946565 1.0163036905873017 0.8278927358108554 1.1108097976493065 1.0 14.389034194120274 -6.953378782350989 10.416044216217081 0.9794090563284232 1.0757243685280833 0.25892523938553824 0.07453486177046394 0.6106770303567811 132.89749824286335 0.024839400014543937 0.021893172821444307 1.1133230934473738e-07 6.953378782350989 0.09631531219966005 S(ph)DSELEVR ddPTM_A459_Selumetinib_30min_R2 1 SDSELEVR 8 0 Q9BQK8;Q9BQK8-2 Q9BQK8 LPIN3 Phosphatidate phosphatase LPIN3 1 S(0.989)DS(0.011)ELEVR 130.41 0.0038281 18156000.0 61837.0 56492.0 45468.0 55644.0 69405.0 59548.0 78251.0 78297.0 82812.0 50003.0 True False 58400.34709312405 60824.75474959018 42542.63838181534 48065.19120874596 60685.723411427534 67750.19647707656 81889.82655141487 78524.8313072338 99376.71396060736 48559.283466603556 1.2026608080674965 1.2525875673479028 0.8760969138079202 0.9898249681093955 1.2497244415306064 1.3952058523201125 1.686388692447125 1.617092051229276 2.0465028902033384 1.0 15.56745951311165 -6.853496852252008 1.9797712641671077 1.6379732574211745 1.0832153169703813 0.423057579719333 0.2616195156920584 0.285930026869429 2.299213061183474 0.10597789595466847 0.09119703808187961 1.401209740811995e-07 6.853496852252008 -0.5547579404507932 S(ph)DSELVSK ddPTM_A459_Selumetinib_30min_R2 2 SDSELVSK 8 0 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7;A0A0A0MS66;Q14693-6 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 S(0.997)DS(0.003)ELVSK;S(0.988)DS(0.012)ELVSK 99.53 0.018576 35637000.0 82552.0 58654.0 69192.0 69906.0 77175.0 69563.0 95371.0 95522.0 83061.0 65352.0 True False 77964.09032183937 63152.57319766451 64740.26205055345 60384.68220542376 67479.58654674617 79144.67181995828 99805.94047405136 95799.95320548172 99675.52091824854 63465.11795511223 1.228455769624221 0.9950753300786618 1.0200920464111183 0.9514625380217963 1.0632547251306348 1.2470578227859896 1.5726109663050236 1.5094898787273878 1.5705559861835803 1.0 15.953676247334085 -6.960670211871409 3.1804144346335734 1.4543192771633173 1.0411330089623818 0.49708782731349976 0.16890765539729502 0.17933442889603407 3.7341870669819275 0.062428203410378864 0.052076542273944156 1.0947873941853175e-07 6.960670211871409 -0.4131862682009355 S(ph)DSLILDHQWELEK ddPTM_A459_Selumetinib_30min_R1 1 SDSLILDHQWELEK 14 0 A0A3B3ITK3;A0A3F2YNW9;A0A3B3IUA1;A0A3B3IU40;A0A3B3IT28;A0A3B3ITE5;A0A3B3ITF7;A0A3B3ITW6;Q12756;Q12756-3;Q12756-2;H7C3Y8 A0A3B3ITK3 KIF1A Kinesin-like protein KIF1A 1 S(0.6)DS(0.4)LILDHQWELEK 152.68 0.00024999 2181100.0 1265.2 1662.9 1698.7 1724.6 1539.2 1470.6 1439.8 1367.4 881.6 1252.3 True False 1294.676698349351 1468.2068949387626 1468.0258702911883 1423.4309847514355 1399.979631767832 1455.807099197966 1331.1947268103695 1331.1321100588225 1496.0108104835933 1413.0449034349797 0.9162318162728681 1.039037677691409 1.0389095680700273 1.007350142441481 0.9907538170688085 1.0302624464792558 0.9420753180414578 0.942031004692749 1.0587142750006961 1.0 10.464591596713019 -7.237987084979864 24.943106059896937 0.9808743836961813 1.0065312516703995 0.030379482560339843 0.045288843882762914 2325.8968728187438 2473751.5805232627 0.017134012479256697 0.013261220360647126 5.781132390427714e-08 7.237987084979864 0.025656867974218178 S(ph)DSLLSFR ddPTM_A459_Selumetinib_30min_R1 2 SDSLLSFR 8 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.981)DS(0.016)LLS(0.002)FR;S(0.73)DS(0.27)LLSFR 152.06 0.0010544 22502500.0 6759.0 8026.599999999999 6699.91 7948.900000000001 7696.3 7055.6 7196.9 6310.3 3859.5 5651.5 True False 6916.471549275425 7086.841940534897 5790.099021971289 6560.773834333004 7000.171023892124 6984.6270699722345 6654.03203874257 6142.93034525683 6549.28961327295 6376.925075271731 1.0846091913633944 1.1113258909087802 0.907976642915875 1.0288303150642615 1.0977345572142911 1.0952970260003578 1.0434546368665043 0.963306024886151 1.0270294124466994 1.0 12.638645215229433 -8.12755853119395 0.007887353572756578 4.2595556285667576e-08 2.048829487333481 0.08398992886801393 0.05940244269501088 4874.466835718406 36.81417679647958 4795.2249721497 4762.9168986988825 7.454893933742615e-09 8.12755853119395 2.0488294447379247 S(ph)DSLLSFR ddPTM_A459_Selumetinib_30min_R2 4 SDSLLSFR 8 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.73)DS(0.27)LLSFR;S(1)DSLLSFR;S(1)DSLLSFR;S(0.685)DS(0.315)LLSFR 154.85 3.1853000000000003e-07 10960400.0 46959.8 42055.7 48196.7 53580.9 59052.2 43479.4 49746.0 47365.1 42943.0 53579.7 True False 44349.9623109738 45281.23695961092 45095.776794599275 46283.08898779199 51633.53470263384 49468.292683304266 52059.287569828935 47502.924599285594 51532.79992767173 52032.714844220915 0.8523476517370223 0.8702455194809068 0.8666812202594095 0.8894997911671043 0.9923282853339065 0.9507151958418047 1.0005106926610994 0.9129434191835479 0.9903922961151295 1.0 15.667131362476479 -6.131132025224547 4.0645292345110535 0.9700974630812027 0.8654832878324843 0.7992951751972438 0.02585551594760357 0.1017705437539823 2.8549710219313935 0.007453592173951129 0.00987904008720531 7.393804697340964e-07 6.131132025224547 -0.10461417524871841 S(ph)DSPVPTAPTSGGPK ddPTM_A459_Selumetinib_30min_R2 1 SDSPVPTAPTSGGPK 15 0 B4E349;F5H6D8;B4DTN4;Q86U44 B4E349 METTL3 N6-adenosine-methyltransferase 70 kDa subunit 1 S(0.668)DS(0.332)PVPTAPTSGGPK 124.16 0.0013575999999999998 12554000.0 78372.0 50560.0 70524.0 82313.0 85357.0 70281.0 94704.0 96443.0 73521.0 57102.0 True False 74016.39798797354 54437.789423976494 65986.56262072554 71101.82740215499 74633.69055873824 79961.56980260326 99107.92365241602 96723.63316300174 88227.25434837713 55453.316891186485 1.33475150157767 0.9816868038894281 1.189947983638345 1.282192506927491 1.3458832535696381 1.4419618930912321 1.787231660946287 1.7442353061188047 1.5910185232292136 1.0 15.758986136047344 -6.546808089904829 1.541517472925725 1.587751618426311 1.1658947696242417 0.2990660155184802 0.22115902381793262 0.3851797137837353 1.8741721649845389 0.08696619840452541 0.09401670304092541 2.839173351679168e-07 6.546808089904829 -0.4218568488020693 S(ph)DSQASLTVPLSPQVVR ddPTM_A459_Selumetinib_30min_R2 1 SDSQASLTVPLSPQVVR 17 0 Q8TEV9-2;Q8TEV9 Q8TEV9-2 SMCR8 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 1 S(0.399)DS(0.297)QAS(0.283)LT(0.02)VPLSPQVVR 85.45 0.011719 2055200.0 9476.9 8945.6 8895.9 8879.0 7137.2 7415.9 6246.7 6416.4 5455.3 6666.4 True False 8950.211837036519 9631.698755362419 8323.54747912358 7669.66488287067 6240.561128622441 8437.372910162421 6537.183927601225 6435.070661707798 6546.512433817562 6473.923710612683 1.382501901028655 1.4877683435739604 1.2857036707860512 1.1847011527642521 0.9639534550572952 1.3032858104785916 1.0097715419297943 0.9939985315487742 1.011212477386146 1.0 12.660424649441604 -5.719853593847277 1.7124602114338947 1.055352587539118 1.4398860723296918 0.7197828959770842 0.09618056208832197 0.19784590837649135 1.1743512640326639 0.030496677112142854 0.0679680062591718 1.9061031811124358e-06 5.719853593847277 0.3845334847905737 S(ph)DSSGGYNLSDIIQSPSSTGLLK ddPTM_A459_Selumetinib_30min_R1 2 SDSSGGYNLSDIIQSPSSTGLLK 23 0 E9PDR5;Q9P2D0-2;Q9P2D0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 S(0.507)DS(0.388)S(0.105)GGYNLSDIIQSPSSTGLLK;S(0.51)DS(0.387)S(0.102)GGYNLSDIIQSPSSTGLLK 148.84 6.689700000000001e-08 30699000.0 7607.5 8729.3 9528.0 9703.9 7930.3 8176.7 7744.5 7261.1 4467.700000000001 6094.0 True False 7784.739948381834 7707.269497858525 8234.149933557677 8009.296029763109 7213.005765208179 8094.449821849593 7160.326129867282 7068.512040623168 7581.360592102491 6876.22426058673 1.1321242084849603 1.1208577855779362 1.1974812951861287 1.164781095880037 1.0489776790079142 1.17716489676544 1.0413165508444762 1.0279641519457992 1.102547023598034 1.0 12.747400882177354 -7.279895465247871 0.7249180803683539 1.0274383076315055 1.152043862823909 0.4764765961613149 0.047084007585309326 0.6270216108494593 0.6490746489260781 0.039947579350569085 0.02527827411687601 5.2493379669443964e-08 7.279895465247871 0.12460555519240346 S(ph)DSSGGYNLSDIIQSPSSTGLLK ddPTM_A459_Selumetinib_30min_R2 2 SDSSGGYNLSDIIQSPSSTGLLK 23 0 E9PDR5;Q9P2D0-2;Q9P2D0 E9PDR5 IBTK Inhibitor of Bruton tyrosine kinase 1 S(0.327)DS(0.327)S(0.327)GGY(0.017)NLSDIIQSPSSTGLLK;S(0.815)DS(0.145)S(0.041)GGYNLSDIIQSPSSTGLLK 113.87 1.5914e-05 0.0 36386.0 33364.0 35067.0 40788.0 35463.0 26251.0 32998.0 32844.0 25430.0 32346.0 True False 34363.8117846987 35922.91151783131 32810.827398062764 35232.60403677543 31007.8208967575 29866.836967148145 34532.47238429654 32939.5706023831 30516.710573567114 31412.08693499907 1.0939678046800145 1.1436015566926983 1.0445287339856821 1.1216257012685005 0.987130239417772 0.9508071535950952 1.09933709453162 1.0486272583717486 0.9714958014956231 1.0 14.939032174521387 -6.259530068978713 24.994592971633654 1.0135482066476413 1.0999501219411363 0.4910806295484924 0.04545237049973741 162.76007500619716 2130673.767305091 0.01421657934145235 0.0174586434932866 5.50135829777555e-07 6.259530068978713 0.08640191529349495 S(ph)DSSLETMENTGVMDK ddPTM_A459_Selumetinib_30min_R2 1 SDSSLETMENTGVMDK 16 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 S(0.999)DS(0.001)SLETMENTGVMDK 199.61 8.073699999999998e-07 3069800.0 14211.0 7751.8 11732.0 11702.0 13119.0 10582.0 8943.9 12260.0 8872.4 12362.0 True False 13421.209511140358 8346.33813403443 10977.175892835781 10108.167412924038 11470.873934651938 12039.574446168213 9359.80907200163 12295.674570247735 10647.127915568884 12005.076939666678 1.1179611408232257 0.6952340393968492 0.9143778043242231 0.8419910562609599 0.95550190909234 1.0028735764606014 0.7796542345409996 1.0242062280851258 0.8868854376425598 1.0 13.551357029275202 -6.274544064593123 24.0185871253744 0.937704910010715 0.8798788526122308 0.035776759103951505 0.1170008668574053 1525.7280768602434 2796385.0963349915 0.0342705826194928 0.03911634303358692 5.314420753426358e-07 6.274544064593123 -0.05782605739848423 S(ph)DSVSASER ddPTM_A459_Selumetinib_30min_R2 1 SDSVSASER 9 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 S(0.546)DS(0.452)VS(0.002)ASER 164.66 0.00097838 17751000.0 42403.0 38553.0 27658.0 38475.0 42348.0 19158.0 30638.0 33883.0 29370.0 33830.0 True False 40046.411012658114 41509.89113256654 25878.514391753502 33234.63862692296 37027.86564407654 21796.84060099135 32062.727708045244 33981.5939203674 35244.82066636514 32853.23999910402 1.2189486033569372 1.2634945939486821 0.7877005248937172 1.0116091632919415 1.1270689175584012 0.6634609128836546 0.9759380721329057 1.034345285922915 1.0727958845863101 1.0 15.003748036250483 -5.241196480338853 24.96759547575814 0.9582563790538569 1.2412216737838149 0.42926167927646275 0.13011304500594761 763.7171650931916 941965.5619031083 0.03348298829047574 0.088349607850743 5.73856783374373e-06 5.241196480338853 0.282965294729958 S(ph)DVYYFSPSGK ddPTM_A459_Selumetinib_30min_R2 1 SDVYYFSPSGK 11 0 X6RBL6;Q9UBB5-3;Q9UBB5 X6RBL6 MBD2 Methyl-CpG-binding domain protein 2 1 S(0.641)DVYYFS(0.314)PS(0.045)GK 98.754 0.017934000000000002 2941700.0 28535.0 26999.0 28263.0 31088.0 29249.0 24516.0 26251.0 24827.0 24392.0 29404.0 True False 26949.138934655548 29069.73648453205 26444.58935042771 26853.760770208744 25574.47913062234 27892.856465910023 27471.723515369686 24899.24245966891 29271.081569423863 28555.03011923308 0.9437615307050266 1.0180250681981349 0.9260921539920248 0.9404213778826149 0.8956208073966203 0.9768106126816145 0.9620624947919862 0.8719739518992194 1.0250761931330792 1.0 14.801457285868286 -8.307904793412174 24.993917959446403 1.0125381855668358 0.9441111662578874 0.34559625571302266 0.03881069218054944 562.6198347614052 302630.43070670334 0.03725644703742482 0.009619668233153965 4.921474130373692e-09 8.307904793412174 -0.06842701930894846 S(ph)EAEDEDDEDYVPYVPLR ddPTM_A459_Selumetinib_30min_R2 1 SEAEDEDDEDYVPYVPLR 18 0 D6RGI7;A0A499FJW5;Q9UJV9;D6RD33 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 S(1)EAEDEDDEDYVPYVPLR 177.04 1.2166e-09 0.0 3987.9 2504.6 7483.4 6370.4 7561.1 6408.2 7871.8 6665.5 2584.7 6471.8 True False 3766.268482828558 2696.6947664416834 7001.926191309858 5502.740530447044 6611.207020908362 7290.871382152252 8237.854297675782 6684.895501467074 3101.712222552061 6284.9423182442015 0.5992526728361008 0.42907231759527875 1.1140796266314752 0.8755435216125137 1.0519121236350992 1.1600538259496824 1.3107287037086375 1.0636367309309858 0.49351482726393164 1.0 12.617683788645195 -5.261095124470612 24.999868771390513 1.0239386847684802 0.5141624614145188 0.47542197022161736 0.20728822120507764 24.871742743404514 1806015.716032762 0.05519392379877557 0.1289655542986821 5.481568877684528e-06 5.261095124470612 -0.5097762233539613 S(ph)EAEEGEVR ddPTM_A459_Selumetinib_30min_R2 2 SEAEEGEVR 9 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(1)EAEEGEVR;S(1)EAEEGEVR 100.69 0.017694 34218000.0 107018.0 75149.0 104962.0 112963.0 110766.0 99467.0 122372.0 155680.0 135653.0 68658.0 True False 101070.36798699739 80912.68665787991 98208.8591939848 97577.2445279558 96850.58481939595 113167.67637847402 128062.54047551776 156133.0030257884 162787.39046150591 66675.66514509253 1.5158509145286927 1.213526501487556 1.4729340754272653 1.463461134067707 1.4525627094778877 1.6972860507984509 1.9206788593235868 2.3416789721711555 2.4414813126688006 1.0 16.024872691477732 -7.059215184185357 2.0388345772383385 2.0484164241208136 1.4116192037448139 0.2669254779728234 0.3748213444024441 0.35582450540934885 2.9390991433544507 0.16317330100518893 0.12157973360581635 8.725389357637084e-08 7.059215184185357 -0.6367972203759997 S(ph)EAGAGPGPK ddPTM_A459_Selumetinib_30min_R1 1 SEAGAGPGPK 10 0 Q9GZP8;Q9GZP8-2;K7EQZ3 Q9GZP8 IMUP Immortalization up-regulated protein 1 S(1)EAGAGPGPK 115.0 0.0050911 0.0 1665.7 2330.1 1999.1 2231.7 1790.5 2437.0 1405.2 1808.7 1412.9 1389.2 True False 1704.5075691120096 2057.2908087658993 1727.6332002702732 1841.9754891973673 1628.5495911384503 2412.485992618961 1299.204632666989 1760.7274005144013 2397.588105866914 1567.517351953903 1.0873931105051877 1.3124516970746742 1.1021461409130728 1.1750909722953646 1.038935606746854 1.5390489869932276 0.8288295061279778 1.1232586346298896 1.5295448582296913 1.0 10.614265697985598 -5.357900963146899 14.872064655644659 1.1684437041381366 1.2019471222312812 0.003648912436783891 0.2144892783684823 19.134450099812728 2912.611114983687 0.05454871432497552 0.11355764619902621 4.386307120612997e-06 5.357900963146899 0.03350341809314461 S(ph)EANDAVNSSTK ddPTM_A459_Selumetinib_30min_R1 1 SEANDAVNSSTK 12 0 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 S(1)EANDAVNSSTK 95.755 0.017746 5327800.0 1969.0 1854.1 1095.8 854.99 1318.0 1343.7 2146.9 2215.9 1358.9 2575.3 True False 2014.8738689929432 1637.0211100522945 946.9963787985414 705.6820466500236 1198.7871327117991 1330.183597981985 1984.957604520894 2157.1271337423896 2305.954049870866 2905.864840546278 0.6933818259125101 0.5633507406161906 0.3258914060918656 0.24284751197077745 0.4125405682965066 0.4577582478791139 0.6830866930988224 0.7423356735810424 0.7935517226043336 1.0 11.504751885634086 -7.805740983356276 1.0481643929741797 0.9406336458368527 0.43243888126406854 0.6883297076826467 0.12383486998183656 0.3330940797835324 0.6617445152533985 0.12224164930151082 0.04803354997004865 1.564080194248463e-08 7.805740983356276 -0.5081947645727842 S(ph)EANDAVNSSTK ddPTM_A459_Selumetinib_30min_R2 4 SEANDAVNSSTK 12 0 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 S(1)EANDAVNSSTK;S(1)EANDAVNSSTK;S(1)EANDAVNSSTK;S(1)EANDAVNSSTK 204.67 2.8476e-05 9724100.0 71987.0 48377.3 53644.5 72151.0 69499.0 73390.0 87162.0 94867.0 88028.0 55996.0 True False 67986.25072679341 52087.68335246317 50193.0712737154 62323.909332582705 60767.91429105684 83498.8063319112 91215.2057082265 95143.04726392259 105636.05970782397 54379.24998491956 1.2502241341255598 0.9578595395653327 0.9230188222094813 1.146097258602617 1.1174834943091159 1.5354902164900595 1.6773899186458487 1.7496204396034818 1.9425802992339714 1.0 15.730768632962526 -6.792677305210235 2.7485823769315205 1.6540391194290553 1.0547531859991437 0.5096174490544483 0.2438531653216174 0.19419102893837445 3.0037998322905204 0.08793102487611798 0.0800931483210655 1.611842841494477e-07 6.792677305210235 -0.5992859334299117 S(ph)EDEDSLEEAGSPAPGPCPR ddPTM_A459_Selumetinib_30min_R1 2 SEDEDSLEEAGSPAPGPCPR 20 0 Q8TBB5-2;Q8TBB5-3;Q8TBB5 Q8TBB5-2 KLHDC4 Kelch domain-containing protein 4 1 S(1)EDEDSLEEAGSPAPGPCPR;S(1)EDEDSLEEAGSPAPGPCPR 358.85 7.749699999999991e-217 31017000.0 679.0 671.86 453.09000000000003 241.92 481.37 531.5 403.89 601.04 180.52 557.53 True False 694.8193788959928 593.1983188607601 391.56286664521923 199.67321340082768 437.83016849277595 526.1535925633885 373.4242521262954 585.0984667469319 306.3292553408556 629.0944063020878 1.1044755317095352 0.9429400626015253 0.6224230619802917 0.31739785221511835 0.6959689421916943 0.8363666681702021 0.5935901645054193 0.930064646713725 0.48693686078295517 1.0 9.297132724023669 -5.086691800259151 3.5952723572188034 0.6731345882117556 1.0802203776697001 0.34128510993909555 0.19294820192461282 0.25053966803051125 5.915187392827475 0.049801806971746757 0.1736366476465862 8.19045822831047e-06 5.086691800259151 0.4070857894579445 S(ph)EDEDSLEEAGSPAPGPCPR ddPTM_A459_Selumetinib_30min_R2 2 SEDEDSLEEAGSPAPGPCPR 20 0 Q8TBB5-2;Q8TBB5-3;Q8TBB5 Q8TBB5-2 KLHDC4 Kelch domain-containing protein 4 1 S(1)EDEDSLEEAGSPAPGPCPR;S(1)EDEDSLEEAGSPAPGPCPR 361.02 5.870799999999997e-217 58467000.0 52926.0 37559.3 55740.0 51760.0 52194.0 47152.0 42664.0 48615.0 44473.0 36981.0 True False 49984.584799564735 40439.97753781567 52153.74908512329 44710.198709019685 45636.92309971972 53646.75999676087 44647.96053711221 48756.4616013535 53368.84267944359 35913.2624418228 1.3918140932068364 1.1260457777492607 1.4522141832591522 1.2449495163923734 1.2707540333782996 1.4937868728485808 1.243216502801411 1.357617166648 1.4860483022364708 1.0 15.1322290961791 -10.764110056550166 5.111124456376522 0.9999556605829502 1.334938923489424 0.4451786686471042 0.11394579055885726 5.508368186552328e-05 8.177222943379977e-06 0.10555670759309124 0.02559788078287501 1.7214322836820057e-11 10.764110056550166 0.33498326290647384 S(ph)EDEESLAGQK ddPTM_A459_Selumetinib_30min_R2 2 SEDEESLAGQK 11 0 F8W126;Q96EZ8-3;Q96EZ8;Q96EZ8-2;F8W0I9;F8VVA6;F8VP44 F8W126 MCRS1 Microspherule protein 1 1 S(1)EDEESLAGQK;S(1)EDEESLAGQK 219.74 1.3154e-05 11168900.0 60314.0 41191.4 55826.0 56068.0 54885.0 56205.0 81051.0 82634.0 57648.0 42461.0 True False 56961.98933607199 44350.64792877341 52234.215938753 48431.44167730516 47989.85562187451 63946.72857180908 84820.03209950964 82874.45125920487 69179.21081970097 41235.040603072914 1.3813976778727137 1.0755572755630636 1.2667434098478954 1.1745214984387808 1.1638124983026745 1.5507861187129193 2.056989173746289 2.0098064667124134 1.6776801916025177 1.0 15.331583207706487 -6.923036426394728 4.1227354207924565 1.7752787488114679 1.2077118785792986 0.3729109260372351 0.2833777709731547 0.1892722543328354 6.228067211888718 0.09934002566673011 0.08614353946159302 1.193887963062792e-07 6.923036426394728 -0.5675668702321692 S(ph)EEHS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 SEEHSPPR 8 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 2 S(1)EEHS(1)PPR 84.198 0.031756 0.0 7549.7 5173.7 6482.3 7509.7 6002.9 5941.5 7009.4 10898.0 5973.2 7677.9 True False 7130.117897843668 5570.506153932501 6065.235875394595 6486.86590504492 5248.762035393104 6759.887693433033 7335.3509888626 10929.711375738983 7168.006905152617 7456.219077420063 0.9562645388781643 0.7470952899978309 0.8134465755924698 0.8699940060357574 0.7039441814804127 0.906610659268884 0.9837896275173176 1.4658516953770608 0.9613460697338885 1.0 12.864228534308815 -7.397413267425505 3.176581975901016 1.1669166028570177 0.8222698819445966 0.46282591120711003 0.14616537196533483 0.19420563570348087 3.6940870735973794 0.06434921635343391 0.04025683335816621 4.004854409448837e-08 7.397413267425505 -0.3446467209124211 S(ph)EGEGEAASADDGSLNTSGAGPK ddPTM_A459_Selumetinib_30min_R1 1 SEGEGEAASADDGSLNTSGAGPK 23 0 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R2I2 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 S(0.998)EGEGEAAS(0.002)ADDGSLNTSGAGPK 86.73200000000001 0.0015405999999999998 0.0 1529.3 1876.2 2172.2 2008.5 1808.7 1690.7 1987.2 1634.3 1025.2 1824.7 True False 1564.929714500208 1656.533631778283 1877.2271710405112 1657.7531792144619 1645.103404351921 1673.6930930327762 1837.303904096101 1590.95305504544 1739.6895223545598 2058.9180190831335 0.7600738348956187 0.8045651242179919 0.9117542095612278 0.8051574486451305 0.7990135542572548 0.8128993371858956 0.8923637983965381 0.7727131630786906 0.8449532745986987 1.0 11.007670671302067 -14.522876613345028 0.44328226922543196 4.810594415029214 0.8215737150060982 0.5777021364258474 0.04563445987803814 910.1167213076454 5.424487795465437 3398.4646364615996 0.02502458595189643 3.0000147269235343e-15 14.522876613345028 -3.9890207000231155 S(ph)EGFSMDR ddPTM_A459_Selumetinib_30min_R1 2 SEGFSMDR 8 0 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;K7ERA4 Q7Z4V5-2 HDGFRP2 Hepatoma-derived growth factor-related protein 2 1 S(1)EGFSMDR;S(1)EGFSMDR 128.91 0.0042103 29321000.0 3517.2999999999997 2641.57 2553.5 3288.8999999999996 2786.8999999999996 2683.0 3326.5 3007.0 1660.15 2389.0 True False 3599.2462465255867 2332.2937563674254 2206.748725371487 2714.555355299199 2534.825387067159 2656.0114559690896 3075.5794268194836 2927.244591887437 2817.1532974414 2695.651420830606 1.3352046257585328 0.8652059900418356 0.8186328203709387 1.0070127518426577 0.9403387127428027 0.9852948476367532 1.1409410738543528 1.0859136197162578 1.0450732893993229 1.0 11.396418235947202 -7.137813349693686 7.684429883562515 1.0748958400901898 0.9758951415286893 0.06374562679935614 0.1339097231420995 0.6564885439913196 38.26341371137648 0.05118662606491559 0.0396256038217969 7.280926556641019e-08 7.137813349693686 -0.09900069856150051 S(ph)EGFSMDR ddPTM_A459_Selumetinib_30min_R2 2 SEGFSMDR 8 0 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;K7ERA4 Q7Z4V5-2 HDGFRP2 Hepatoma-derived growth factor-related protein 2 1 S(1)EGFSMDR;S(0.999)EGFS(0.001)MDR 133.75 0.002981 33918000.0 31472.0 30187.0 40836.0 45381.0 41750.0 30945.0 38543.0 35599.0 36049.0 39356.0 True False 29722.912232398092 32502.24583349639 38208.65621887506 39200.02951340849 36504.99175026438 35207.39285925868 40335.32587150562 35702.58719626829 43259.8072932175 38219.69002083174 0.7776858529254828 0.850405793866485 0.999711305822976 1.0256501162631726 0.9551357358044307 0.921184678370463 1.0553546051661002 0.9341412025269829 1.131872269755161 1.0 15.222028456995579 -5.129132965936828 2.8899141551364784 0.999341744799157 0.7847009707591249 0.6347199568603107 0.05838057541360403 0.17084114437794773 2.6247999679173524 0.014938434669152035 0.05711527594531292 7.4279168597774525e-06 5.129132965936828 -0.21464077404003212 S(ph)EGSEYEEIPK ddPTM_A459_Selumetinib_30min_R1 2 SEGSEYEEIPK 11 0 P48634 P48634 PRRC2A Protein PRRC2A 1 S(1)EGSEYEEIPK;S(0.999)EGS(0.001)EYEEIPK 212.68 1.9668e-05 14025700.0 5353.4 6047.5 4251.5 3666.8 5051.3 4151.0 6884.4 6690.4 2835.2 6003.799999999999 True False 5478.123804096913 5339.455888593527 3674.1696518178505 3026.46221436076 4594.41080687945 4109.244708806443 6365.104165337758 6512.948858518023 4811.12732518499 6774.446211964331 0.8086452578842552 0.7881759957239793 0.5423571959769803 0.4467468069959332 0.678197252310495 0.6065801661468825 0.9395755706342999 0.9613994494510152 0.7101875451735185 1.0 12.725887300514945 -7.260484384561893 24.99009741638994 0.8995739363791205 0.6394356890826206 0.5126435303521466 0.12299019292736052 77.04861300054338 2016229.8336353474 0.05217090190640688 0.038048824929682305 5.4892829244928486e-08 7.260484384561893 -0.2601382472964999 S(ph)EGSEYEEIPK ddPTM_A459_Selumetinib_30min_R2 1 SEGSEYEEIPK 11 0 P48634 P48634 PRRC2A Protein PRRC2A 1 S(1)EGSEYEEIPK 196.02 2.0556e-05 8909900.0 27433.0 20924.0 26244.0 26286.0 25934.0 19397.0 31506.0 35067.0 22236.0 16705.0 True False 25908.38368300004 22528.80351873583 24555.489612306694 22705.801454120792 22675.939067098363 22068.760681565378 32971.091427954634 35169.03916434563 26683.821325750625 16222.683245197548 1.597046758012105 1.388722394330488 1.5136515483390167 1.3996329158952459 1.397792136132054 1.3603643952117763 2.0324067806548074 2.167892859201133 1.64484635016528 1.0 13.985724841791466 -7.246728282892132 24.4344723857756 1.8086109129242374 1.439610413221794 0.13011242441067783 0.300386986220936 799.9627226304813 1328703.7557905915 0.109762404821009 0.08462107344269415 5.6659366849470955e-08 7.246728282892132 -0.3690004997024434 S(ph)EIPSPQSQLLEDAEANLVGR ddPTM_A459_Selumetinib_30min_R1 1 SEIPSPQSQLLEDAEANLVGR 21 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 S(0.623)EIPS(0.376)PQSQLLEDAEANLVGR 271.58 4.7897999999999987e-60 8322400.0 4010.6 4870.7 5210.3 5289.1 5233.1 4570.6 4570.8 4517.3 2695.3 3835.4 True False 4104.039176730878 4300.4361796730045 4502.769878129259 4365.457973703363 4759.767028978844 4524.623913772761 4226.020876027807 4397.486529741642 4573.727243076714 4327.71094995969 0.9483163788397432 0.9936976451056789 1.040450697884802 1.0087221684119232 1.0998347819470657 1.0455004888473212 0.9765025725822031 1.0161229760001882 1.0568467478446812 1.0 12.079388428700751 -4.91005027601716 2.318597956525814 1.0314996942535566 0.939267277727442 0.3880598362057326 0.0322960959591531 0.47545952681404996 3.839725294022859 0.0089828296916999 0.0809416843326683 1.2301263572281723e-05 4.91005027601716 -0.09223241652611458 S(ph)ELSPVAR ddPTM_A459_Selumetinib_30min_R1 1 SELSPVAR 8 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.991)ELS(0.009)PVAR 96.034 0.021405 30222000.0 3424.4 3933.6 4468.3 4670.4 3915.4 3320.5 3928.1 3574.9 2018.9 3117.1 True False 3504.1818572775223 3473.052283318973 3861.5294026150054 3854.802314265978 3561.252761320016 3287.0987847727774 3631.8002544685482 3480.0820390882577 3425.9258453780935 3517.2101481251875 0.9962958452014561 0.9874452014674892 1.0978955592611814 1.0959829387279405 1.0125220306265479 0.934575600074659 1.0325798293299142 0.9894438752666739 0.9740463893532912 1.0 11.780215821104013 -6.518647592561416 24.956583903395895 0.9867254657571989 1.045419025494526 0.316957213697724 0.04031270292292009 232.44117623650402 1371018.013309396 0.014079000586675591 0.014405867150601827 3.029370608098245e-07 6.518647592561416 0.05869355973732704 S(ph)ENGSVWK ddPTM_A459_Selumetinib_30min_R1 2 SENGSVWK 8 0 P16157-14;H0YBS0;P16157-15;P16157-12;P16157-21;P16157;P16157-3;P16157-16;P16157-5;P16157-8;P16157-10;P16157-13;P16157-4;P16157-7;P16157-6;P16157-9;P16157-11;P16157-2 P16157-14 ANK1 Ankyrin-1 1 S(1)ENGSVWK;S(1)ENGSVWK 96.492 0.021035 1501800000.0 8802.9 10723.5 9407.1 11041.7 8905.0 8191.200000000001 9549.1 8035.9 4583.6 6854.0 True False 9007.99044253834 9467.987634780096 8129.66748950152 9113.474373379298 8099.544322305446 8108.803965014534 8828.803698975478 7822.761827718075 7778.034427101406 7733.77766361363 1.1647594273261446 1.2242384054206379 1.0511897087177071 1.1783988071259086 1.0472946953741247 1.0484919941732165 1.1415900589583532 1.0115059118550955 1.0057225285510856 1.0 12.916957574010043 -3.0252243647850108 0.18905809023051504 0.9789563269571794 1.5969401955010938 0.5488301710542497 0.05221505828351053 23.574130574891683 0.4497437479853835 0.11258374988886416 3.7939896237984345 0.0009435732824522087 3.0252243647850108 0.6179838685439144 S(ph)EPSLEPESFR ddPTM_A459_Selumetinib_30min_R1 1 SEPSLEPESFR 11 0 Q9C0B5-2;Q9C0B5;H0YEF4 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5;Palmitoyltransferase 1 S(0.999)EPS(0.001)LEPESFR 133.89 0.0017335 2310100.0 558.11 514.65 554.43 468.27 525.69 326.32 438.85 656.06 213.91 488.57 True False 571.1128771069842 454.3945387457058 479.14145126599357 386.49543501655734 478.14143231810743 323.03751707485395 405.747191179838 638.6591576167841 362.9896466317441 551.2827185748044 1.0359709417038239 0.8242495609519969 0.8691392549084197 0.7010838939695752 0.8673252692451807 0.5859743216873947 0.7360056419486357 1.1584966045514147 0.6584455387430931 1.0 9.106648566793805 -10.167659029413626 8.722566509726247 0.999986867250549 0.8250690583180488 0.09207982174256901 0.1635898156410239 0.0 0.0 0.15603954151523838 0.03784514773178117 6.797370941415156e-11 10.167659029413626 -0.1749178089325002 S(ph)ES(ph)GYGFNVRGQVY(ph)NVY(ph)MAGRQLCS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 SESGYGFNVRGQVYNVYMAGRQLCSK 26 2 A0A2R8Y8A7 A0A2R8Y8A7 5 S(0.687)ES(0.668)GY(0.647)GFNVRGQVY(0.998)NVY(1)MAGRQLCS(1)K 40.669 0.028235000000000007 9489900.0 4017.9 4389.0 5333.1 4815.5 4205.8 3030.5 5037.4 4764.5 3559.6 4933.7 True False 3794.6012029280746 4725.622187140681 4989.974152240239 4159.620592799156 3677.429803670948 3447.9238668600206 5271.649081418734 4778.363906194563 4271.619463533993 4791.251261707939 0.791985432543442 0.9863023099849153 1.041476198946298 0.8681699968530505 0.7675301508525046 0.7196291069967676 1.1002656286365469 0.9973102317516986 0.8915457007385765 1.0 12.22618675760117 -7.275975398014873 24.99709998763966 0.9970562295221096 0.8722162752511408 0.29232237564942576 0.10205554289177936 1301.2745853464266 2237748.7502662 0.04711136285468408 0.031912645013903625 5.296934492032687e-08 7.275975398014873 -0.12483995427096883 S(ph)ESAPTLHPYSPLSPK ddPTM_A459_Selumetinib_30min_R2 1 SESAPTLHPYSPLSPK 16 0 Q8WUF5;K7EN03 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 S(0.471)ES(0.374)APT(0.155)LHPYSPLSPK 109.72 0.0019324 27477000.0 41597.0 37536.0 43831.0 46625.0 49575.0 33704.0 32955.0 42058.0 26951.0 35290.0 True False 39285.20526598448 40414.890502736984 41010.9611795845 40274.59456738876 43346.9452938768 38346.42006555027 34487.47279909368 42180.38181692329 32341.953073857945 34271.086005568475 1.1463075684149984 1.1792707851793853 1.1966636007076317 1.175177073782979 1.2648255525615282 1.1189146459881552 1.0063139753870083 1.2307862613419862 0.9437096060685944 1.0 15.06470428923622 -7.866700509858506 0.7439313508141768 0.9907135464929195 1.18852443956041 0.455605334473528 0.07538703517553012 0.6131656335589711 0.6640038234528136 0.06903690097794155 0.031367760261058274 1.359250464672764e-08 7.866700509858506 0.19781089306749045 S(ph)ESETSTMAAK ddPTM_A459_Selumetinib_30min_R1 4 SESETSTMAAK 11 0 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 S(0.996)ES(0.003)ETST(0.001)MAAK;S(0.997)ES(0.003)ETSTMAAK;S(0.993)ES(0.001)ET(0.003)S(0.001)T(0.002)MAAK;S(0.958)ES(0.037)ET(0.003)S(0.001)T(0.001)MAAK 139.76 0.001142 57942900.0 8783.300000000001 8457.0 7789.599999999999 7508.299999999999 8079.4 7062.200000000001 7461.9 7935.1 4106.2699999999995 7115.9 True False 8987.933800673301 7466.85050844736 6731.815105210005 6197.11635324667 7348.619696533925 6991.160679964558 6899.042875389844 7724.635371162619 6968.040279905247 8029.295079735659 1.1193926380109078 0.9299509401880376 0.838406739117082 0.7718132528080773 0.9152260097004502 0.8707066573762938 0.8592339435626988 0.9620564812293497 0.8678271517871092 1.0 12.971057618654909 -4.786174032198406 3.3529321108828256 0.8798918957394941 1.1497165615887812 0.5697051499090866 0.060506332844565164 0.21556752296544637 3.8639745031739396 0.015241541398250779 0.1504590095564174 1.636160741255058e-05 4.786174032198406 0.2698246658492871 S(ph)ESGGSEYGTGPGR ddPTM_A459_Selumetinib_30min_R2 1 SESGGSEYGTGPGR 14 0 A0A5F9ZHX5;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 S(0.756)ES(0.099)GGS(0.145)EYGTGPGR 123.95 0.0015538 7051800.0 9116.5 6096.7 8209.7 8194.1 6466.7 5778.3 7835.5 7875.3 4312.1 6072.9 True False 8609.84142624101 6564.297286019724 7681.496840045513 7078.049444389074 5654.295332968498 6574.208374815132 8199.866275748698 7898.215819173905 5174.64049014073 5897.559597710871 1.4598990113780126 1.1130531497414027 1.302487361556647 1.2001658189493174 0.9587517072592543 1.114733690417796 1.3903829439776183 1.3392345915825228 0.8774206355030748 1.0 12.525902377336232 -1.5228787454642525 0.03277670852414523 0.34387619329540026 2.4365463636720444 0.2082249173206968 0.1652341139802727 2325.4003666714775 5.856046982251157 114.40553585073962 300.29100198222625 0.029999999987295606 1.5228787454642525 2.092670170376644 S(ph)ESLSNCSIGK ddPTM_A459_Selumetinib_30min_R1 1 SESLSNCSIGK 11 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.527)ES(0.17)LS(0.303)NCSIGK 211.22 1.9158e-05 29192000.0 2360.9 3033.0 2336.2 2689.4 2759.3 2487.3 2375.4 2981.0 1404.9 2414.8 True False 2415.9043764882913 2677.894949996554 2018.956871828027 2219.746776290452 2509.7218021939825 2462.280020287706 2196.2216655544876 2901.9341963473385 2384.0126901637946 2724.7631021438865 0.8866474940839516 0.9827991827581428 0.7409660202163924 0.8146567951334633 0.921078900481034 0.9036675586036619 0.8060229763925039 1.065022568040521 0.8749431054347498 1.0 11.411915088416231 -7.7528113578413125 24.999970450118035 0.9774871375959656 0.8665648207582276 0.31900157538575313 0.07686452456534479 227.5026922095127 659201.4832833526 0.036932884385462064 0.020895277913089465 1.7668050916630954e-08 7.7528113578413125 -0.11092231683773801 S(ph)ESLSNCSIGK ddPTM_A459_Selumetinib_30min_R2 1 SESLSNCSIGK 11 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.957)ES(0.042)LS(0.001)NCSIGK 141.34 0.0010117 22785000.0 62860.0 54562.0 56706.0 81610.0 63489.0 48762.0 51608.0 61645.0 47394.0 50289.0 True False 59366.49284851754 58746.72995551831 53057.59769682458 70494.57721489744 55512.94422113859 55478.52288263596 54007.874259311975 61824.37674412088 56874.12429900271 48837.0259034863 1.2156041804396525 1.2029137497360296 1.0864215564985293 1.4434658112517267 1.1366978884186254 1.1359930678881809 1.1058796734683336 1.2659324682526882 1.1645697756329316 1.0 15.575687724736813 S(ph)ESNEDLFGLVPFDEITGSQQQK ddPTM_A459_Selumetinib_30min_R2 2 SESNEDLFGLVPFDEITGSQQQK 23 0 H0Y9P1;Q9NSY1 H0Y9P1 BMP2K BMP-2-inducible protein kinase 1 S(0.916)ES(0.084)NEDLFGLVPFDEITGSQQQK;S(0.827)ES(0.173)NEDLFGLVPFDEITGSQQQK 119.91 7.0304e-06 6688000.0 15016.099999999999 12221.3 13747.6 15798.2 13562.2 9365.5 12453.3 11582.1 8758.7 14143.6 True False 14181.565276211002 13158.634412326812 12863.094383255131 13646.457906584905 11858.395188393677 10655.512613455714 13032.403125745808 11615.801993480134 10510.68473852546 13735.237518513972 1.0324950884246025 0.9580201576121311 0.9365032359954997 0.9935363613618331 0.8633556698535089 0.7757792756836537 0.9488298333522954 0.8456935657518108 0.7652350186414993 1.0 13.745594238184507 -6.269238153236904 22.260684645140067 0.8583491071864002 0.9754419971382753 0.38221145340555773 0.07023331596131674 134.92030645671045 385113.4124573424 0.020994125876463227 0.02432431709048804 5.379746934581602e-07 6.269238153236904 0.11709288995187506 S(ph)ESPDLILHDSGVSAAR ddPTM_A459_Selumetinib_30min_R1 2 SESPDLILHDSGVSAAR 17 0 P0CG40 P0CG40 SP9 Transcription factor Sp9 1 S(0.5)ES(0.5)PDLILHDSGVSAAR;S(0.5)ES(0.5)PDLILHDSGVSAAR 95.5 0.004213399999999999 12029600.0 2601.2 3700.1 1858.31 3001.5 5804.0 2818.5 5571.1 2665.6 779.5999999999999 1562.9699999999998 True False 2661.8028989458858 3266.8905718701762 1605.961708966161 2477.344370133037 5279.029224779426 2790.148448993247 5150.867441681656 2594.899628910923 1322.9242602688405 1763.5924241170392 1.509307288093248 1.8524067846944732 0.9106195326112282 1.404714794787886 2.9933385699490214 1.582082351249702 2.9206677071435543 1.471371499120658 0.7501303828355785 1.0 10.784301469341079 S(ph)ESPDLILHDSGVSAAR ddPTM_A459_Selumetinib_30min_R2 2 SESPDLILHDSGVSAAR 17 0 P0CG40 P0CG40 SP9 Transcription factor Sp9 1 S(0.558)ES(0.442)PDLILHDSGVSAAR;S(0.499)ES(0.499)PDLILHDS(0.001)GVSAAR 98.269 0.0034777 12248100.0 14768.2 10211.8 22866.3 36253.0 35841.0 17716.3 15637.0 19958.2 20292.4 26530.0 True False 13947.442565788682 10995.012223887717 21395.107152945006 31315.278860086768 31338.33315739462 20156.55951244091 16364.151484127677 20016.275057742125 24351.447017029233 25764.00996678184 0.5413537172113912 0.4267585767147215 0.8304261324432894 1.215466028015915 1.2163608536792172 0.782353350213311 0.6351554554289636 0.776908372708658 0.9451730164840855 1.0 14.65306953468519 -5.351463465178645 4.709374226901381 0.9278125780359597 0.48525487375594983 0.5059439528954224 0.17621526527597697 0.19410696478015121 7.268782117976096 0.05371063122682061 0.11809907707515169 4.45180911982122e-06 5.351463465178645 -0.4425577042800099 S(ph)ESPKEPEQLR ddPTM_A459_Selumetinib_30min_R2 1 SESPKEPEQLR 11 1 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.979)ES(0.021)PKEPEQLR 120.59 0.022248 3141500.0 13389.0 10116.0 9358.4 10252.0 9937.0 8914.8 9391.1 8702.3 7030.3 10088.0 True False 12644.892980413635 10891.86467193327 8756.290732655503 8855.659914313565 8688.62522209287 10142.732779502954 9827.804758111626 8727.622252256686 8436.556442994448 9796.73322822824 1.290725457745315 1.1117853694892421 0.8937969962706739 0.9039400898247312 0.8868900499461928 1.0353178496560214 1.0031716215150022 0.8908706656530132 0.8611601690536405 1.0 13.258085039897352 -4.972319622111815 2.716002479474337 0.9340688214648503 1.2995177369920634 0.797555845779474 0.05713752650683111 0.14363467010251077 1.8722984257359716 0.0161784221672803 0.09815720040728901 1.0658114410121897e-05 4.972319622111815 0.36544891552721315 S(ph)ESPPAELPSLR ddPTM_A459_Selumetinib_30min_R2 2 SESPPAELPSLR 12 0 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.995)ES(0.005)PPAELPSLR;S(0.635)ES(0.365)PPAELPSLR 173.72 0.00017223 149617500.0 37993.0 35391.0 47075.0 44060.0 49689.0 35566.0 37978.0 42390.0 34393.0 36424.0 True False 35881.501158029394 38105.375899999046 44046.24575138461 38058.951992260605 43446.62359470391 40464.89366399721 39744.05225197932 42513.34788195772 41272.56102071151 35372.34447908262 1.014394202206412 1.0772646388347993 1.245217030424186 1.0759522036987599 1.2282653082380786 1.143969795044998 1.1235911228751576 1.2018809753223432 1.1668030951445125 1.0 15.110334223588332 -5.024152757224067 8.318552704444121 1.1551759958790735 1.0294572183581616 0.27634886187210983 0.0689017463231786 0.2251631573390253 73.11658191286263 0.01593432798926322 0.04609682868267936 9.459043937385672e-06 5.024152757224067 -0.12571877752091187 S(ph)ESPPAELPSLRR ddPTM_A459_Selumetinib_30min_R2 2 SESPPAELPSLRR 13 1 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.53)ES(0.47)PPAELPSLRR;S(0.5)ES(0.5)PPAELPSLRR 93.716 0.008595700000000001 14147000.0 32962.0 42279.0 45670.0 51152.0 48356.0 28260.0 29830.0 29773.0 24091.4 40807.0 True False 31130.10399734068 45521.66335158823 42731.64192173628 44185.00935787821 42281.08697187508 32152.558481261913 31217.154107023638 29859.634500814507 28910.35316995811 39628.79588068101 0.7855425153736898 1.1487016534302517 1.0782977623240857 1.1149722916365052 1.0669283795344147 0.811343311516973 0.7877391531404556 0.7534832648137826 0.7295289328750932 1.0 15.274261511292341 -6.771998657285849 9.482664365917682 0.7989700626571363 1.0514910405965727 0.47772379379504015 0.11521451090249574 0.13595914542207752 99.40190933329828 0.03864859949042348 0.03534962740575173 1.6904461580105425e-07 6.771998657285849 0.2525209779394364 S(ph)ESPQEALLLPR ddPTM_A459_Selumetinib_30min_R1 2 SESPQEALLLPR 12 0 H7BY14;A0A087WYU3;Q96NU1-6;Q96NU1;I7G285 H7BY14 SAMD11 Sterile alpha motif domain-containing protein 11 1 S(0.606)ES(0.394)PQEALLLPR;S(0.608)ES(0.392)PQEALLLPR 131.08 0.0020759 4607300.0 2603.4 2751.8999999999996 2616.6 2727.0 3041.5 2172.9 2975.2 2498.7 1319.1100000000001 2108.2 True False 2664.054154665431 2429.7062686763975 2261.2800919549786 2250.780642129867 2766.3968620204387 2151.0425988353463 2750.7782686527366 2432.426359078527 2238.433326017483 2378.8080056069807 1.1199113793068247 1.0213965410194714 0.9505937791637734 0.9461800350531248 1.1629340642455759 0.9042522951685135 1.1563683416942443 1.0225400088385297 0.9409894874833837 1.0 11.216023120722596 -9.038617815189498 0.004422381057725601 3.734469244996623e-05 2.0234582783715855 0.023716432365816442 0.08796638464394087 86885.30021392592 159.96984161635302 37001.5910101466 36184.181608934035 9.149180271085662e-10 9.038617815189498 2.0234209336791356 S(ph)ESSDFEVVPK ddPTM_A459_Selumetinib_30min_R2 1 SESSDFEVVPK 11 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.959)ES(0.027)S(0.014)DFEVVPK 160.56 0.00060085 4165400.0 37118.0 28099.0 36080.0 39964.0 37693.0 24138.0 38865.0 40565.0 33400.0 24094.0 True False 35055.130155126855 30254.10294747459 33758.65208093379 34520.83425825468 32957.66836030458 27462.79039705237 40672.29950953651 40683.03743410271 40080.93327397333 23398.343616269958 1.4981885354804085 1.2930019083247202 1.4427795674160382 1.475353761120541 1.4085470707160477 1.173706602802269 1.7382555011823644 1.7387144193323967 1.712981650808102 1.0 14.514118783666941 -7.27509314482668 24.943255984213845 1.6090474169152391 1.386109747293207 0.09290229321195087 0.22209786330424475 1306.4166975802757 2386605.5954178176 0.0876334768427614 0.05943154868528686 5.307705955886282e-08 7.27509314482668 -0.2229376696220322 S(ph)ESVEGFLSPSR ddPTM_A459_Selumetinib_30min_R1 3 SESVEGFLSPSR 12 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.962)ES(0.038)VEGFLS(0.001)PSR;S(0.933)ES(0.047)VEGFLS(0.019)PSR;S(0.843)ES(0.156)VEGFLSPSR 118.76 0.004442 16244400.0 4330.18 4207.51 4384.200000000001 4897.200000000001 4219.59 4017.7200000000003 3878.0 3797.13 1702.18 3239.66 True False 4431.06476893645 3714.8927731816702 3788.8497206867737 4041.9959518292576 3837.92882952912 3977.3053845978848 3585.479337804288 3696.417777583485 2888.475137691658 3655.5019179606834 1.2121631634674217 1.01624697690054 1.0364786575739187 1.1057294025670188 1.0499047506095163 1.0880326351508873 0.9808446058221578 1.0111929525797179 0.7901719661258088 1.0 11.835853793394747 -7.662199686770965 1.5790416469820345 0.9070242936913433 1.0794597205937948 0.47334391063197256 0.07404112770630748 0.3426063105909085 1.6356381797162651 0.05160684764781417 0.021959514944874043 2.176708700747099e-08 7.662199686770965 0.1724354269024515 S(ph)ESVEGFLSPSR ddPTM_A459_Selumetinib_30min_R2 2 SESVEGFLSPSR 12 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.981)ES(0.019)VEGFLSPSR;S(0.994)ES(0.005)VEGFLS(0.001)PSR 168.82 0.00037276 6106800.0 23154.6 29128.0 33098.0 30062.0 28369.3 25995.0 21745.4 19854.6 18460.300000000003 27092.6 True False 21867.76002720783 31362.02393871811 30968.51071437766 25967.503740157474 24805.294909240118 29575.575290884753 22756.60418769265 19912.37359889402 22152.87582387814 26310.366242971482 0.8311461659356245 1.1920025608574005 1.1770459760380776 0.9869685393335944 0.9427955004566526 1.1241035194173907 0.8649292061364527 0.7568261655883786 0.8419827994525174 1.0 14.683343710654588 -7.337556059841051 6.668888059456035 0.8435364962503041 1.047993424253391 0.3461240077623323 0.11716684911729962 0.2613370562442788 19.176255623398667 0.04956556642921275 0.033254590687454615 4.5966764962679356e-08 7.337556059841051 0.2044569280030869 S(ph)EVLAEESIVCLQK ddPTM_A459_Selumetinib_30min_R1 2 SEVLAEESIVCLQK 14 0 O43663-3;O43663-2;O43663-4;O43663;H0YLA0;H0YM42 O43663-3 PRC1 Protein regulator of cytokinesis 1 1 S(1)EVLAEESIVCLQK;S(1)EVLAEESIVCLQK 222.55 4.8087e-09 12722700.0 2581.4700000000003 2926.08 2406.38 2255.1800000000003 2402.92 2327.41 2597.67 2345.59 1588.79 2046.0900000000001 True False 2641.6132283337824 2583.4931933023145 2079.6068132991754 1861.3551479715547 2185.5763102699834 2303.9983685192005 2401.7256605038842 2283.3773336499007 2696.060589369587 2308.7255821043505 1.144186753423511 1.1190126766592674 0.9007596352805436 0.8062262411780322 0.9466591990018496 0.9979524575714879 1.0402819976182558 0.9890206750204823 1.1677700503981896 1.0 11.172880987499145 -7.6850359131761 1.6037773407542066 1.0706575047939615 0.9791784541704057 0.08812267222945558 0.10188567775290397 1.030740052777918 5.074181049466636 0.08378881580735534 0.035064433512170666 2.0652093700935356e-08 7.6850359131761 -0.09147905062355577 S(ph)FADIGK ddPTM_A459_Selumetinib_30min_R2 3 SFADIGK 7 0 Q9Y6M7-6;Q9Y6M7-13;Q9Y6M7-11;C9JRP1;Q9Y6M7-2;Q9Y6M7-9;Q9Y6M7-7;Q9Y6M7-14;Q9Y6M7-3;Q9Y6M7;Q9Y6M7-4;E7EW28;Q6U841-2;Q6U841-4;F8WDX9;Q6U841;Q6U841-3;C9J240 Q9Y6M7-6 SLC4A7;SLC4A10 Sodium bicarbonate cotransporter 3;Anion exchange protein;Sodium-driven chloride bicarbonate exchanger 1 S(1)FADIGK;S(1)FADIGK;S(1)FADIGK 104.2 0.018145 16541900.0 185214.0 46783.0 126673.0 134961.0 78957.0 92759.0 256323.0 154239.0 104905.0 81983.0 True False 174920.54735038689 50371.10566894564 118522.9970911345 116579.07897928917 69037.71577546406 105535.71026763537 268242.5273943891 154687.80995435908 125888.93129060413 79615.93777258479 2.1970544120202473 0.6326761585453634 1.48868430627149 1.4642681131545046 0.8671343666473365 1.3255600978925588 3.3692064038810656 1.942925176567157 1.581202643749467 1.0 16.28076964252788 -7.051694818950763 24.99881895579126 2.094121253562263 1.286385896243302 0.16742967113303875 0.679255574486354 492.89186858135577 238353.34725605842 0.2501968665702233 0.19380370833899477 8.877796403880985e-08 7.051694818950763 -0.8077353573189612 S(ph)FAGNLNTYK ddPTM_A459_Selumetinib_30min_R1 2 SFAGNLNTYK 10 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 S(0.997)FAGNLNTY(0.003)K;S(1)FAGNLNTYK 184.87 0.00018291 764200000.0 10112.5 10937.9 7572.0 7750.7 7932.4 7933.099999999999 8254.2 8361.3 4576.4 7432.799999999999 True False 10348.101574500331 9657.285583108245 6543.763990018763 6397.185743658216 7214.915820578965 7853.300216678491 7631.579048505452 8139.531162669912 7765.816552968602 8386.872281603062 1.2338451364281895 1.151476409661309 0.780238898399916 0.7627617935342472 0.8602629893870174 0.936380089381475 0.9099433963297169 0.9705085387462377 0.9259490656610128 1.0 13.033917170999326 -5.135937522659256 5.088847841675826 0.8891651331564412 1.2133725940990605 0.7335171867328429 0.07269011944767743 0.11383148117494221 4.153121371442977 0.020471275463709027 0.058240998779851415 7.312442722745099e-06 5.135937522659256 0.3242074609426193 S(ph)FAGNLNTYK ddPTM_A459_Selumetinib_30min_R2 4 SFAGNLNTYK 10 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 S(1)FAGNLNTYK;S(0.996)FAGNLNT(0.001)Y(0.003)K;S(1)FAGNLNTYK;S(1)FAGNLNTYK 162.93 0.00040065 797510000.0 737089.0 605781.0 711764.0 796314.0 762019.0 588962.0 792375.0 763484.0 571070.0 574790.0 True False 696124.5441810531 652242.4548070794 665969.8791500499 687854.6594817308 666287.3606837054 670086.1694352796 829222.0075612747 765705.6120384193 685299.9570289787 558194.3192162287 1.2471007321581038 1.1684863717762402 1.1930789265020665 1.2322853096168387 1.1936476917558965 1.200453222770451 1.4855436162904725 1.371754576638403 1.2277085836187325 1.0 19.090407916504212 S(ph)FAGNLNTYKR ddPTM_A459_Selumetinib_30min_R1 1 SFAGNLNTYKR 11 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 S(1)FAGNLNTYKR 68.033 0.037534 91728000.0 3885.9 2825.0 6986.2 7165.4 5782.9 4002.9 3852.6 3884.9 3255.2 2453.5 True False 3976.43390935484 2494.2476866931315 6037.512412449695 5914.097401216483 5259.837716053919 3962.6344603424045 3561.9952802539465 3781.8598320663427 5523.836649598676 2768.430624113808 1.4363494879441747 0.9009608783285137 2.1808429511873144 2.1362635385199957 1.8999348115279668 1.4313649133291424 1.2866478391143226 1.3660663189914466 1.9952953133390838 1.0 11.434852653559096 -6.790481474828131 23.14844482880807 1.4306768263900849 1.715617824590826 0.1130017635872852 0.4120925499408729 250.64364158341002 199776.04023622742 0.1562796344172206 0.13786141862235826 1.6200130953594591e-07 6.790481474828131 0.28494099820074115 S(ph)FAGNLNTYKR ddPTM_A459_Selumetinib_30min_R2 2 SFAGNLNTYKR 11 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 S(1)FAGNLNTYKR;S(1)FAGNLNTYKR 93.766 0.020054 78633000.0 118847.0 139570.0 122343.0 165134.0 138616.0 87854.0 69119.0 58758.0 59215.0 111078.0 True False 112241.95952223614 150274.57021171646 114471.58457698698 142642.464327961 121201.81883723721 99955.09104079199 72333.17045670014 58928.97605208946 71059.65460533924 107870.88952469644 1.0405213122539327 1.3930966071927304 1.0611906982632173 1.3223443781401636 1.123582269241311 0.9266178436204313 0.6705532027724669 0.5462917410966376 0.658747275733464 1.0 16.718946060257537 -6.936351377159989 2.2219793586021637 0.6811801806905843 1.2078231515611964 0.6875380760456131 0.14880990112484724 0.15570303530566346 1.5590051665143683 0.05878386445155562 0.04829258391275859 1.157840196594068e-07 6.936351377159989 0.5266429708706121 S(ph)FDASDTLALPR ddPTM_A459_Selumetinib_30min_R1 2 SFDASDTLALPR 12 0 Q5JXC2 Q5JXC2 MIIP Migration and invasion-inhibitory protein 1 S(0.994)FDAS(0.001)DT(0.005)LALPR;S(1)FDASDTLALPR 137.95 0.0026789 3234000.0 1698.24 1724.63 1883.06 1733.9499999999998 1731.42 1569.1 1476.27 1873.65 1302.8899999999999 1393.75 True False 1737.8056878001923 1522.7095178412646 1627.3507949081784 1431.1481827726734 1574.8133667070294 1553.31627862881 1364.9137653482044 1823.9547155270682 2210.9091706794134 1572.6513887746573 1.1050164710401689 0.9682435209164154 1.0347816474292757 0.9100225218303231 1.0013747343802981 0.9877054061161563 0.8679061202570054 1.1597959525843904 1.4058482295952819 1.0 10.618983187185899 -7.930758134487374 6.615544855054012 1.2288612806675163 0.9827044467533915 0.4252206982674265 0.10980525379564304 0.15940911849852155 11.927111837395517 0.05700266795971056 0.02695316499174804 1.1728483616281847e-08 7.930758134487374 -0.2461568339141248 S(ph)FDASDTLALPR ddPTM_A459_Selumetinib_30min_R2 2 SFDASDTLALPR 12 0 Q5JXC2 Q5JXC2 MIIP Migration and invasion-inhibitory protein 1 S(1)FDASDTLALPR;S(0.997)FDAS(0.002)DT(0.001)LALPR 125.53 0.0028641 2617800.0 11758.7 8635.900000000001 14353.1 11423.4 12826.900000000001 10837.8 12283.1 11518.7 10275.3 10801.9 True False 11105.198527805645 9298.245761204873 13429.637172473678 9867.513213535845 11215.470148059068 12330.608574247004 12854.288488500908 11552.217509976559 12330.647115869995 10490.021080293289 1.0586440620856366 0.8863896163824396 1.2802297602340187 0.9406571386279771 1.0691561115285668 1.1754608003039642 1.2253825221237322 1.1012577974393902 1.1754644744265133 1.0 13.356729956645186 -6.636420445073805 5.574603414087532 1.1469204816596748 1.042648367964066 0.13632015194054903 0.11094372298553724 0.3840266887375643 17.316474333002994 0.03575408536604852 0.03564930405010775 2.3098275389662848e-07 6.636420445073805 -0.10427211369560885 S(ph)FDDPIVQTER ddPTM_A459_Selumetinib_30min_R1 1 SFDDPIVQTER 11 0 D6RJ96;E9PDE8;O95757 D6RJ96 HSPA4L Heat shock 70 kDa protein 4L 1 S(1)FDDPIVQTER 127.71 0.0029145 2414000.0 890.99 1590.7 1129.2 1714.7 1151.4 1390.9 1080.5 884.79 529.66 881.58 True False 911.7483334352578 1404.4601045036327 975.8608422516094 1415.2598339054207 1047.25607329618 1376.9088088361557 998.9970150844599 861.3224949970348 898.7943351641792 994.7393803163858 0.9165700599339578 1.411887507717782 0.9810216239164353 1.4227443508422122 1.0527944243678085 1.3841905086719473 1.0042801510147512 0.8658775474668384 0.9035475552182418 1.0 9.95817478178706 -7.478762460129228 7.8367803768358035 0.9173990524994853 1.1989696208826304 0.35199097713905025 0.16971283976917656 0.27958081878304225 45.29464692681854 0.06568536575024754 0.04353745298350996 3.3207603879361016e-08 7.478762460129228 0.2815705683831451 S(ph)FDEVEGVFGR ddPTM_A459_Selumetinib_30min_R1 4 SFDEVEGVFGR 11 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JW88 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 S(1)FDEVEGVFGR;S(1)FDEVEGVFGR;S(1)FDEVEGVFGR;S(1)FDEVEGVFGR 150.14 0.00061878 20715000.0 2100.9900000000002 2353.37 2465.96 2880.4 2025.3899999999999 2200.86 2537.33 2388.89 1297.0529999999999 1832.1599999999999 True False 2149.938979185112 2077.83634634797 2131.096176548688 2377.392211804497 1842.1938321116486 2178.721346620994 2345.9371552838966 2325.5288769916774 2201.0042079970253 2067.335582749686 1.0399564527039962 1.0050793706091572 1.0308419176504457 1.149978857637818 0.8910956921959496 1.0538788984240082 1.1347635937091805 1.1248918155312637 1.0646574394417143 1.0 11.013556879652858 -7.004233076028806 24.998661811826558 1.0918909263786911 1.024086589219654 0.13044009617614805 0.06804919748063495 315.22383966182633 1861578.940654598 0.02400353125148351 0.0206866448248058 9.903003304566705e-08 7.004233076028806 -0.06780433715903711 S(ph)FDEVEGVFGR ddPTM_A459_Selumetinib_30min_R2 2 SFDEVEGVFGR 11 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JW88 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 S(1)FDEVEGVFGR;S(1)FDEVEGVFGR 147.33 0.00066847 3926300.0 3352.9 4938.1 4822.3 4883.9 4990.799999999999 2109.8199999999997 6215.4 4412.6 2879.47 6353.299999999999 True False 3166.5592407221516 5316.836391505898 4512.038468123252 4218.704394802575 4363.811085681904 2400.4285539609327 6504.428415581452 4425.439935454748 3455.4444591140104 6169.863721144182 0.5132300134718248 0.8617429220170697 0.7313027762121314 0.6837597369201259 0.7072783586332841 0.38905698123195837 1.0542256214332115 0.7172670476154478 0.5600519906577789 1.0 12.591022908396459 -11.125283197463059 3.00391481670324 1.019123488154754 0.6999523467978964 0.21881691852931662 0.17446418962392174 165364830.23376307 174048449.2649819 24988171.03645546 0.04369233838786685 7.494053730235277e-12 11.125283197463059 -0.31917114135685754 S(ph)FDGNTLLNR ddPTM_A459_Selumetinib_30min_R1 2 SFDGNTLLNR 10 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 S(1)FDGNTLLNR;S(1)FDGNTLLNR 138.42 0.0016385000000000002 19300000.0 2717.6 3203.5 3192.8 3783.6000000000004 3320.8 2957.1 3038.5 2665.6000000000004 1499.53 2437.6 True False 2780.914792470912 2828.432730733255 2759.235296795022 3122.865286968302 3020.4342263348594 2927.3542588319765 2809.3034986896146 2594.899628910923 2544.592888662052 2750.4897042346934 1.0110616986456542 1.0283378724808747 1.0031796492627707 1.135385194192981 1.0981441674493657 1.064302932792288 1.021383026580456 0.9434318641206977 0.9251417610269037 1.0 11.425472787289992 -7.611218155759337 3.401643397463919 0.9505697396712235 1.0578646183674398 0.5409287436138206 0.0412057229135997 0.1935246743889098 4.430126100588227 0.02356076064105736 0.012649324621695057 2.447833331942017e-08 7.611218155759337 0.10729487869621634 S(ph)FDGNTLLNR ddPTM_A459_Selumetinib_30min_R2 4 SFDGNTLLNR 10 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 S(1)FDGNTLLNR;S(1)FDGNTLLNR;S(1)FDGNTLLNR;S(0.992)FDGNT(0.008)LLNR 150.09 0.00072349 28640000.0 58361.0 56430.0 62399.0 53316.0 53380.0 33478.600000000006 45213.9 45435.6 37100.3 44265.1 True False 55117.5292575936 60757.999548951586 58384.316274894285 46054.268824769955 46673.92717674522 38089.9732615278 47316.43593964317 45567.81007373152 44521.39666899379 42987.051548458185 1.2821891074678857 1.413402346994203 1.3581837825997245 1.0713521203670873 1.085767120457911 0.8860801541271087 1.100713685522362 1.0600357184852307 1.035693192839848 1.0 15.391614539828932 -5.792541101387247 4.453485333405657 1.0320830574188264 1.3607280538583812 0.8413726298829229 0.06322273799729643 0.07148115700010407 3.216636792434374 0.018005232982890192 0.028864476554526737 1.612348428362028e-06 5.792541101387247 0.3286449964395548 S(ph)FDHLISDTK ddPTM_A459_Selumetinib_30min_R2 2 SFDHLISDTK 10 0 H0Y465;P21359-2;P21359-6;P21359;J3QSG6 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 S(1)FDHLISDTK;S(1)FDHLISDTK 135.1 0.0013244 6961700.0 162210.0 84585.0 133762.0 169925.0 156639.0 99902.0 146503.0 168983.0 106580.0 119580.0 True False 153195.0175780788 91072.39751635777 125155.89854905405 146780.9218630249 136960.60844957276 113662.5936799374 153315.67979018722 169474.7125533583 127898.97809401412 116127.41469384721 1.3191976931713745 0.7842454579433866 1.0777463605730748 1.2639644329462698 1.179399445089251 0.9787748567346656 1.3202367433597086 1.459385908143683 1.1013676523429106 1.0 16.825349070016706 -5.594650317097326 6.385236530303085 1.2009019969501051 1.0227749138960052 0.08413763946468678 0.1816639758392462 0.3782818068056909 26.09551423489149 0.04903463440396527 0.08594625434831984 2.543019456215422e-06 5.594650317097326 -0.17812708305409997 S(ph)FDYNYR ddPTM_A459_Selumetinib_30min_R1 2 SFDYNYR 7 0 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.915)FDY(0.077)NY(0.009)R;S(0.857)FDY(0.106)NY(0.037)R 114.97 0.013385 447180000.0 8533.3 11039.0 6593.5 7104.3 8290.2 6510.6 10749.4 9840.099999999999 5059.9 9144.7 True False 8732.109287088622 9746.548748108129 5698.138915502998 5863.667369227435 7540.352873753693 6445.109275151829 9938.564103608414 9579.108582850526 8586.280739525797 10318.511321921158 0.8462566948526475 0.9445692740000272 0.5522249031599732 0.5682667960803967 0.7307597616077227 0.6246161945337521 0.9631780974542747 0.9283421109884515 0.8321239829707484 1.0 13.332947224011965 -7.268965259400536 24.984578444218233 0.9249395673988822 0.7089046175545602 0.44906359560803844 0.11917873841700745 624.4171827692013 2072944.30884292 0.053703239669889644 0.03699184577035103 5.383128421535756e-08 7.268965259400536 -0.21603494984432192 S(ph)FDYNYR ddPTM_A459_Selumetinib_30min_R2 6 SFDYNYR 7 0 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.999)FDY(0.001)NYR;S(0.959)FDY(0.002)NY(0.04)R;S(0.992)FDYNY(0.007)R;S(1)FDYNYR;S(0.85)FDY(0.052)NY(0.098)R;S(0.989)FDY(0.004)NY(0.007)R 119.68 0.0099704 1309942000.0 354797.0 242867.0 315743.0 338141.0 366476.0 290528.0 357030.0 388060.0 317578.0 287025.0 True False 335078.8031049229 261494.11795951196 295428.4391349852 292085.6124742397 320436.0085429914 330545.59484940086 373632.6024415239 389189.19035320834 381102.47387071565 278737.8424694902 1.2021288538946755 0.9381364067497736 1.0598791915644605 1.0478864652409388 1.1495963580117952 1.1858655140648202 1.3404444804885818 1.3962553017744903 1.3672433943461766 1.0 18.088549355733512 -6.797556075299768 1.7583774026181576 1.3063751100741852 1.0549874264590295 0.36325214501610903 0.12115704437305193 0.3143152659032068 2.0079086206151087 0.04945755418202258 0.04394474410462493 1.5938370741324727e-07 6.797556075299768 -0.2513876836151556 S(ph)FDYNYRR ddPTM_A459_Selumetinib_30min_R2 1 SFDYNYRR 8 1 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.94)FDY(0.004)NY(0.056)RR 63.32 0.046524 21033000.0 36337.0 50188.0 43653.0 62774.0 51853.0 21128.0 18813.0 14712.0 13626.0 40596.0 True False 34317.53500853614 54037.25822014498 40844.41350579273 54224.07290880995 45338.76256829843 24038.19021911189 19687.841777252284 14754.809484297286 16351.58074225032 39423.887998924845 0.8704756621029371 1.3706729844001855 1.0360321008142734 1.3754116009635764 1.15003275601673 0.609736670816624 0.49938863913648507 0.37426063823790473 0.41476327100706695 1.0 15.266782442084278 -6.784651137069235 4.376433149197326 0.525643128427156 1.181808536986509 0.6482068607246749 0.21278826815287538 0.11274182725705191 4.977397386440998 0.07159386847156964 0.06567889031148103 1.641908166406891e-07 6.784651137069235 0.656165408559353 S(ph)FEDLTDHPVTR ddPTM_A459_Selumetinib_30min_R1 2 SFEDLTDHPVTR 12 0 P78536 P78536 ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 1 S(1)FEDLTDHPVTR;S(1)FEDLTDHPVTR 175.01 7.9047e-05 5678600.0 2150.3999999999996 2240.2 2578.5 2103.92 2666.8 2413.7 2994.7 2914.3999999999996 1098.46 2361.7 True False 2200.5001360499887 1977.9163425592737 2228.3538626866593 1736.5098674696994 2425.588410861781 2389.4203694642524 2768.807367953199 2837.1006446946244 1864.006391655864 2664.847199906085 0.8257509609284687 0.7422250486365521 0.836203240007604 0.651635811438231 0.9102166949561927 0.8966444190678028 1.0390116806887757 1.0646391450866715 0.6994796518620489 1.0 11.379837097099577 -6.435136718594397 6.47511969267637 0.9453990496890698 0.7676924118956566 0.3889056161021056 0.10538702596425291 0.2529949500169533 15.552577562448183 0.03238601658752989 0.03661694559458223 3.6716669595116326e-07 6.435136718594397 -0.17770663779341322 S(ph)FEDLTDHPVTR ddPTM_A459_Selumetinib_30min_R2 2 SFEDLTDHPVTR 12 0 P78536 P78536 ADAM17 Disintegrin and metalloproteinase domain-containing protein 17 1 S(1)FEDLTDHPVTR;S(0.999)FEDLT(0.001)DHPVTR 121.13 0.0025556 5819900.0 36151.0 13206.0 25146.0 25699.0 19114.300000000003 15851.6 35234.0 24102.0 22404.1 19515.6 True False 34141.872143919165 14218.85773601728 23528.133736894706 22198.75186675226 16712.990749989916 18035.014013502165 36872.450814846474 24172.132829699112 26885.54602285706 18952.133920381748 1.801479046494172 0.7502510163631682 1.2414503736485198 1.171306194859619 0.8818527148553027 0.9516086203942827 1.9455566834715445 1.2754306681900134 1.418602577198099 1.0 14.210072677709839 S(ph)FEEEGEHLGSR ddPTM_A459_Selumetinib_30min_R1 1 SFEEEGEHLGSR 12 0 Q9BXW6-4;Q9BXW6 Q9BXW6-4 OSBPL1A Oxysterol-binding protein-related protein 1 1 S(0.994)FEEEGEHLGS(0.006)R 134.04 0.0016559 9632600.0 480.02 478.94 502.12 477.86 525.96 321.3 441.76 397.15 251.59 364.46 True False 491.20353204367325 422.86548214683484 433.9348619477312 394.41072154315276 478.38701086578016 318.06801371705853 408.4376875369837 386.61629187499 426.92985459342975 411.2419911410308 1.1944391444093085 1.0282643583490916 1.0551813075890835 0.9590721036264365 1.1632737443432004 0.7734327246946451 0.9931808918727723 0.9401187140502982 1.0381475233326038 1.0 8.683843772686734 -1.5228787453084933 0.615928269485636 0.9706604531456429 15.698037458271088 0.30964517042692796 0.09263367495944669 223.59874663165832 1.6371120992270922 0.039649755250192306 4452.018533866373 0.02999999999805507 1.5228787453084933 14.727377005125446 S(ph)FEEEGEHLGSR ddPTM_A459_Selumetinib_30min_R2 2 SFEEEGEHLGSR 12 0 Q9BXW6-4;Q9BXW6 Q9BXW6-4 OSBPL1A Oxysterol-binding protein-related protein 1 1 S(1)FEEEGEHLGSR;S(1)FEEEGEHLGSR 160.87 0.00031537 29262000.0 17698.3 19647.3 17175.6 27145.6 22607.8 17558.6 17434.5 13660.0 15002.3 18122.5 True False 16714.699337908325 21154.184733973358 16070.540595379323 23448.322451228072 19767.606047703637 19977.137768898974 18245.23879580636 13699.74833846527 18003.17919928533 17599.256337090235 0.949738955883169 1.2019931029353297 0.913137480787233 1.3323473448029162 1.1232068940347002 1.1351126085252465 1.036705099712351 0.7784276833103001 1.0229511323921017 1.0 14.103226848101844 -7.530104517149949 24.640616898941243 0.9219268635382739 1.1128796632881206 0.27669900023183447 0.12653591823967178 175.68429306544934 599088.7389474399 0.05650326816732866 0.03271557743400327 2.9504990751974306e-08 7.530104517149949 0.1909527997498467 S(ph)FEEKVENLK ddPTM_A459_Selumetinib_30min_R1 1 SFEEKVENLK 10 1 H0YC42;P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;E5RK35 H0YC42 TPD52 Tumor protein D52 1 S(1)FEEKVENLK 75.483 0.032911 87935000.0 4683.4 4810.9 4797.9 5951.5 4888.5 5486.4 4729.9 5082.9 1933.0 4909.7 True False 4792.514107689969 4247.637591473266 4146.371532978212 4912.182248491348 4446.336038134775 5431.211797252631 4373.119834935665 4948.0849804139125 3280.159819265865 5539.907819527843 0.8650891429631093 0.766734344658335 0.7484549685759212 0.8866902498226055 0.8026010870545006 0.9803794529049628 0.7893849459950723 0.8931709951873585 0.5920964619128677 1.0 12.43564625562672 -2.3414234040283053 18.35289715289773 0.8289228053173036 0.8690448425363001 0.0 0.1138704104038149 0.0 0.0 0.024392811185242985 0.0 0.00455592531362238 2.3414234040283053 0.04012203721899654 S(ph)FEMTEFNQALEEIK ddPTM_A459_Selumetinib_30min_R1 1 SFEMTEFNQALEEIK 15 0 Q9BVS4-2;Q9BVS4;H0Y919 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 S(0.998)FEMT(0.002)EFNQALEEIK 114.06 0.0026079 14214000.0 1203.2 1271.5 1012.7 1258.2 1332.2 1002.8 1361.1 1274.6 778.91 1609.3 True False 1231.2322189803515 1122.6321888956875 875.1809023629165 1038.4789893391262 1211.7027452190127 992.7127424695502 1258.431131172103 1240.7934675157048 1321.7533806644467 1815.8693309094567 0.6780400979423467 0.618234015953907 0.48196248896642385 0.5718908137619221 0.6672852085739813 0.5466873224695974 0.6930185502620019 0.6833054815096569 0.7278901395412973 1.0 10.82644467537929 -8.934182186955667 0.5703203646493712 1.0124916957263341 0.5863658645748946 0.8111285344934857 0.05762240799755009 0.6584328497915266 0.40440364283682845 0.07729146655094032 0.027026103901568798 1.163637779831727e-09 8.934182186955667 -0.42612583115143954 S(ph)FEMTEFNQALEEIK ddPTM_A459_Selumetinib_30min_R2 2 SFEMTEFNQALEEIK 15 0 Q9BVS4-2;Q9BVS4;H0Y919 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 S(0.999)FEMT(0.001)EFNQALEEIK;S(1)FEMTEFNQALEEIK 142.32 0.00038188 36947000.0 60141.0 42790.0 53727.0 57708.0 58380.0 57115.0 82506.0 86878.0 77665.0 49237.0 True False 56798.60398349818 46071.85540846425 50270.2633135346 49848.070848147356 51045.78247617809 64982.07281165157 86342.69248253755 87130.80059657275 93200.17014141113 47815.39987691058 1.187872612792379 0.9635359220474017 1.0513404351515094 1.042510801467088 1.0675594600815503 1.3590197505182957 1.8057507143055658 1.8222330215970242 1.9491663853347014 1.0 15.545187720514985 -6.9991682877358254 2.9118781928081052 1.7107430056758914 1.0548624496723578 0.5430830255062619 0.2479159964790484 0.17565200880689244 3.030651845445068 0.09402925280954273 0.07594723800165046 1.0019169232138511e-07 6.9991682877358254 -0.6558805560035337 S(ph)FEVEEVETPNST(ph)PPRR ddPTM_A459_Selumetinib_30min_R2 1 SFEVEEVETPNSTPPRR 17 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 2 S(1)FEVEEVETPNS(0.18)T(0.82)PPRR 149.67 0.00042321 1964300.0 12579.0 11107.0 14035.0 12471.0 15653.0 8096.4 11484.0 12015.0 9688.4 12463.0 True False 11879.909537726724 11958.87118536604 13132.003380152595 10772.428286325046 13686.530200404508 9211.605608198475 12018.028755114292 12049.961660809671 11626.350716513873 12103.160807237173 0.9815543003132741 0.9880783520793301 1.0850061061983263 0.8900508270437583 1.130822800620855 0.7610909046742839 0.9929661306266396 0.9956045245308407 0.9606044984184472 1.0 13.563096244026946 S(ph)FEVEEVETPNSTPPR ddPTM_A459_Selumetinib_30min_R1 4 SFEVEEVETPNSTPPR 16 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 1 S(1)FEVEEVETPNSTPPR;S(1)FEVEEVETPNSTPPR;S(0.992)FEVEEVET(0.008)PNSTPPR;S(1)FEVEEVETPNSTPPR 347.52 1.216699999999999e-155 189441000.0 6360.0 7235.900000000001 6835.5 8420.3 6874.0 5588.0 6401.3 6792.5 3276.65 5499.049999999999 True False 6508.175625594277 6388.717464121357 5907.276644713848 6949.852673606935 6252.247913703273 5531.789793498053 5918.444787283805 6612.340834850486 5560.235732952663 6204.906632782978 1.0488756738431824 1.0296234644961832 0.9520331238351545 1.1200575745794648 1.0076296524221933 0.8915186191958825 0.9538330127345219 1.065663228502887 0.8961030458662724 1.0 12.59919378648679 -6.531202479919374 24.986592424269663 0.963333227981016 1.0350695870772746 0.26578011533681034 0.059934673786884614 279.90997367674504 840241.5371519661 0.019586566707655365 0.019619380325734175 2.9430491841768797e-07 6.531202479919374 0.07173635909625864 S(ph)FEVEEVETPNSTPPR ddPTM_A459_Selumetinib_30min_R2 2 SFEVEEVETPNSTPPR 16 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 1 S(1)FEVEEVETPNSTPPR;S(1)FEVEEVETPNSTPPR 254.72 5.7413999999999986e-30 138608000.0 29475.0 26488.6 27835.4 29714.0 29894.0 17303.9 24638.2 23531.1 20226.3 27894.0 True False 27836.897497773698 28520.190445726716 26044.500668892022 25666.901940490956 26138.4484642492 19687.35515583538 25783.925119667096 23599.571605216697 24272.125170040905 27088.627742684228 1.0276230218155495 1.0528473688900357 0.9614551507108295 0.9475157687684185 0.9649233144085108 0.7267756544497646 0.9518357801136866 0.8711984907242186 0.8960263842304094 1.0 14.725399690809253 -5.722922758345306 1.2557549208820082 0.8891635751565408 1.0443039813796693 0.3599871242628394 0.07039267770765754 0.5041168702001987 1.5526775955659622 0.023917335457033357 0.064979046527177 1.892680212264244e-06 5.722922758345306 0.15514040622312852 S(ph)FEVEEVETPNSTPPRR ddPTM_A459_Selumetinib_30min_R1 2 SFEVEEVETPNSTPPRR 17 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 1 S(1)FEVEEVETPNSTPPRR;S(0.95)FEVEEVET(0.05)PNSTPPRR 140.3 0.00025887 104470000.0 3175.0 2234.0 2321.9 2450.81 2091.95 2291.0 2650.2 2020.79 1292.34 1593.21 True False 3248.971322525444 1972.442241441576 2006.5987332837503 2022.8220409014668 1902.7334918637696 2267.9546200615664 2450.29328031174 1967.192084748989 2193.0065912209266 1797.7140226795834 1.807279289996686 1.0971946686501068 1.1161946271592262 1.1252190367221748 1.0584183401026428 1.2615769757867636 1.3630050438497745 1.0942742059812105 1.2198862352712472 1.0 10.811947822268428 -4.758231262706662 24.999999999988255 1.157062337556005 1.8072801843870128 0.7928624843493017 0.10094180959444393 41.016193722690744 319574.8933833485 0.025749314847092586 0.17950102615225624 1.7448927465034422e-05 4.758231262706662 0.6502178468310078 S(ph)FEVEEVETPNSTPPRR ddPTM_A459_Selumetinib_30min_R2 4 SFEVEEVETPNSTPPRR 17 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 1 S(1)FEVEEVETPNSTPPRR;S(1)FEVEEVETPNSTPPRR;S(1)FEVEEVETPNSTPPRR;S(1)FEVEEVETPNSTPPRR 217.35 1.3595999999999995e-39 77437100.0 37342.9 32060.5 36071.8 41071.5 32135.1 18458.6 17954.5 19332.7 17583.6 30587.3 True False 35267.5311134729 34519.43725924442 33750.97966000631 35477.49084771065 28098.001446560982 21001.10459951242 18789.419826166806 19388.95495629923 21100.81132683344 29704.165173650446 1.1872924523311472 1.162107639027857 1.1362372738872883 1.1943608123746068 0.9459279963702115 0.7070087469800964 0.6325516881664213 0.6527352256140331 0.7103654051032294 1.0 14.85837762215961 -6.533472082442687 2.7130108895462857 0.7110152007983427 1.1669524829260163 0.8060127446475881 0.09857211946143231 0.10547069338527872 1.5724777255820948 0.03295138580486351 0.03496953140872679 2.9277090659287907e-07 6.533472082442687 0.4559372821276736 S(ph)FEVVR ddPTM_A459_Selumetinib_30min_R2 2 SFEVVR 6 0 Q9UKY7;D6R9V8;H0Y8K3 Q9UKY7 CDV3 Protein CDV3 homolog 1 S(1)FEVVR;S(1)FEVVR 98.629 0.034365 10001200.0 41816.0 31441.0 38995.0 43128.0 49141.0 40409.0 42503.0 43382.0 40688.0 35569.0 True False 39492.03412271096 33852.423601250885 36486.104154545814 37253.892000050255 42967.468253886065 45974.9729536204 44479.47371809676 43508.23443772327 48826.7369177074 34542.0305506394 1.1433037807321358 0.9800357147974397 1.0562813932161967 1.078509033956044 1.2439184254352038 1.3309864018046087 1.2876913432430916 1.2595737350744107 1.413545646835275 1.0 15.0760652736274 -6.271215402170813 3.427460644890705 1.2775625762832477 1.0537849407621476 0.43433590796790755 0.10601518024442876 0.19813414551667263 4.964469996103288 0.03149382741011929 0.03869028481624686 5.35530977999525e-07 6.271215402170813 -0.22377763552110008 S(ph)FGHFPGPEFLDVEK ddPTM_A459_Selumetinib_30min_R1 2 SFGHFPGPEFLDVEK 15 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 S(1)FGHFPGPEFLDVEK;S(1)FGHFPGPEFLDVEK 148.15 0.00020516 17387900.0 7046.4 7819.7 7381.8 8056.7 6677.299999999999 7105.9 7594.5 7565.7 4565.4 6489.5 True False 7210.567410092369 6904.165888720092 6379.392105324944 6649.748587989616 6073.339393973067 7034.421097640978 7021.640750632968 7365.033059142925 7747.150356376813 7322.490538082962 0.9847151556688941 0.9428712611935463 0.8712052370906959 0.9081266207727362 0.8294089780501205 0.9606596363704689 0.9589142811608525 1.0058098430907771 1.0579939046811015 1.0 12.838118708557838 -7.521270189217671 1.6738353155275798 1.0282822988111402 0.9092184988341012 0.5527041870839593 0.04292427717195146 0.2942372711748966 1.6035428728315624 0.029279375057878906 0.014297182132464713 3.0111321146774727e-08 7.521270189217671 -0.11906379997703898 S(ph)FGTRPLSSGFSPEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R1 1 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.336)FGT(0.065)RPLS(0.236)S(0.236)GFS(0.128)PEEAQQQDEEFEK 65.301 0.0012383 9930500.0 628.73 769.51 762.03 861.83 696.46 620.89 623.55 549.83 320.38 518.22 True False 643.3781857043849 679.4154114645067 658.5505115311674 711.3275690527258 633.4653159700001 614.6444103230145 576.5151214770149 535.2467223004552 543.6614603706145 584.738584890262 1.1002834468758853 1.1619130822229096 1.1262306414322867 1.2164881665645868 1.0833307948865434 1.0511439234651583 0.9859365131261341 0.9153607032806036 0.9297513015540843 1.0 9.191647982721891 -6.994354533771686 1.5157656511587405 0.9435290802065699 1.1489313370377583 0.8382110636647871 0.03781605385803875 0.14250116415843578 0.6644111503267173 0.0187220956320091 0.013980951741679655 1.0130840228326755e-07 6.994354533771686 0.2054022568311884 S(ph)FLEDTTPAR ddPTM_A459_Selumetinib_30min_R2 3 SFLEDTTPAR 10 0 Q3YEC7;Q3YEC7-2;G3V154;F2Z2T0 Q3YEC7 RABL6 Rab-like protein 6 1 S(1)FLEDTTPAR;S(1)FLEDTTPAR;S(0.999)FLEDTTPAR 108.98 0.010346 75885600.0 43719.0 38256.0 46749.0 54269.0 54662.0 47394.0 49802.0 56592.0 52823.0 43803.0 True False 41289.2730010235 41190.11218757208 43741.22023646268 46877.46858075326 47794.87087551981 53922.09330010354 52117.89168079088 56756.67335069004 63389.07599793689 42538.29357613817 0.9706377367282241 0.9683066414934343 1.0282786769095809 1.1020063251208825 1.1235728295018002 1.2676129850763715 1.2251993979849343 1.334248945578947 1.4901649941476487 1.0 15.376474540289948 -6.321652099466402 0.9468559042687726 1.297134950323133 0.9672052571678155 0.5079558088639131 0.11624732754024984 0.42692030038209 0.8192297894731244 0.05522205383086019 0.08198854755989454 4.7681279456060374e-07 6.321652099466402 -0.3299296931553176 S(ph)FLEDTTPARDEK ddPTM_A459_Selumetinib_30min_R1 1 SFLEDTTPARDEK 13 1 Q3YEC7;Q3YEC7-2;G3V154;F2Z2T0 Q3YEC7 RABL6 Rab-like protein 6 1 S(1)FLEDTTPARDEK 85.45 0.015282 4244800.0 1720.5 2503.3 2301.1 2436.0 2463.0 2788.9 2705.6 2369.7 1392.1 1825.0 True False 1760.5843024897729 2210.2124722474023 1988.6232590375291 2010.598329383335 2240.222084877969 2760.8461981185956 2501.514413708942 2306.8478581295826 2362.2920250388056 2059.2565270053788 0.8549611373819743 1.0733060418953957 0.9656996265197876 0.9763709877890718 1.0878790745588918 1.3407004721910416 1.214765805475778 1.1202333598933676 1.147157721274342 1.0 11.00790784614561 -6.444622159572316 4.228280980186499 1.1787461069299547 0.9769628333912782 0.4848725427175363 0.09444889346043181 0.19190185067351997 6.369546840815066 0.03014774449506861 0.03373365291827135 3.5923433609917176e-07 6.444622159572316 -0.20178327353867653 S(ph)FLESNYFTKPNLK ddPTM_A459_Selumetinib_30min_R1 2 SFLESNYFTKPNLK 14 1 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 S(1)FLESNYFTKPNLK;S(0.999)FLES(0.001)NYFTKPNLK 95.073 0.025164 11985000.0 2118.21 3629.8 3292.9 3623.7 2738.4 2900.8 3443.8999999999996 2957.7 1454.89 2344.32 True False 2167.5601716808255 3204.821328551759 2845.742266604962 2990.888820273559 2490.712203503787 2871.620585715665 3184.123850300204 2879.252188036405 2468.8420690386542 2645.236307610549 0.8194202406206915 1.2115444353047933 1.075798883607314 1.1306698050637445 0.9415840075753594 1.0855818731407063 1.2037200007951026 1.0884669092710448 0.9333162643865144 1.0 11.369180893424703 -8.254134607118127 24.158630621436135 0.9666581316159205 1.0773085862823726 0.11714560277141262 0.11144177302834814 635.1492608416555 2100619.002771762 0.07609335648844473 0.02740294283150533 5.570130791211062e-09 8.254134607118127 0.11065045466645207 S(ph)FLNYYADLETSAR ddPTM_A459_Selumetinib_30min_R1 2 SFLNYYADLETSAR 14 0 Q92870-2;H0YAJ5;G5E9Y1;Q92870;Q92870-4 Q92870-2 APBB2 Amyloid beta A4 precursor protein-binding family B member 2 1 S(0.927)FLNY(0.001)Y(0.071)ADLET(0.001)S(0.001)AR;S(1)FLNYYADLETSAR 156.17 0.00032289 4389400.0 786.72 702.78 1090.23 923.21 993.22 923.66 795.06 745.25 566.48 842.92 True False 805.04904530936 620.4981908864414 942.1827542047216 761.9887042980245 903.3834263672336 914.368819016179 735.0879840935213 725.4835490868346 961.2751859377801 951.1169927360952 0.8464248367526913 0.6523889233662445 0.9906065829970377 0.8011513936955306 0.9498131494512093 0.961363140391171 0.7728681010933057 0.7627700426209642 1.0106802772732117 1.0 9.893479001374777 -8.258421675807693 0.023752760827866336 1.8019320937178795 4.614122579842688e-06 0.18473141515889946 0.1065702957626274 380.7042870403522 7.787738092223784 299.17334111071614 289.02098557752515 5.515416629134139e-09 8.258421675807693 -1.8019274795952998 S(ph)FLVASVLPGPDGNINSPTR ddPTM_A459_Selumetinib_30min_R1 1 SFLVASVLPGPDGNINSPTR 20 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 S(0.71)FLVAS(0.001)VLPGPDGNINS(0.273)PT(0.016)R 206.36 1.3262e-16 39315000.0 5186.2 6483.0 6942.2 7852.4 7190.3 5893.0 6411.8 5925.5 3632.3 5389.7 True False 5307.028369411483 5723.96734613507 5999.487370774989 6481.125747803656 6539.938634550572 5833.721770415893 5928.152763830201 5768.336491263384 6163.747807304402 6081.520495123776 0.8726482749941749 0.941206619417727 0.9865110831387379 1.0657081157582693 1.0753788694446331 0.9592538206676159 0.9747813509110845 0.9485023516550662 1.0135208476640927 1.0 12.570216354470721 -4.971928546270575 2.1671050228077076 1.0036513194989471 0.863867782969146 0.5310863911273891 0.038946291610720114 0.3924405861871624 2.8563836156943294 0.011895737214668394 0.09226202186001486 1.0667716209055006e-05 4.971928546270575 -0.13978353652980113 S(ph)FNDFR ddPTM_A459_Selumetinib_30min_R1 1 SFNDFR 6 0 P42356 P42356 PI4KA Phosphatidylinositol 4-kinase alpha 1 S(1)FNDFR 101.46 0.030433 22342000.0 11507.0 14839.0 13517.0 13882.0 13066.0 12665.0 12779.0 11835.0 6814.4 9908.9 True False 11775.09071127568 13101.642981536057 11681.465643566244 11457.769297413566 11884.182606989656 12537.601598899926 11815.069741568079 11521.0973545021 11563.53909591584 11180.803835859508 1.0531524284068157 1.1717979470774686 1.0447786952581168 1.0247715160394608 1.0629094993039985 1.121350645531303 1.0567281132036614 1.030435514622946 1.0342314618586552 1.0 13.448736292982758 -7.347888541982988 0.01139680332143461 4.826924048260744e-09 2.1130591462012105 0.27940783333203745 0.040657176915535796 1507.800343356708 11.193434459426053 1020.5694423038555 1052.8555335977014 4.488605714333954e-08 7.347888541982988 2.1130591413742863 S(ph)FNDFR ddPTM_A459_Selumetinib_30min_R2 3 SFNDFR 6 0 P42356 P42356 PI4KA Phosphatidylinositol 4-kinase alpha 1 S(1)FNDFR;S(1)FNDFR;S(1)FNDFR 101.46 0.030433 55089000.0 269225.0 202125.0 241832.0 253744.0 279671.0 208224.0 283149.0 260833.0 213376.0 213922.0 True False 254262.55229306602 217627.3375656892 226272.7924067736 219183.62946718483 244536.22868953735 236904.96593072455 296315.9895490997 261591.98084677215 256057.1622235726 207745.5160238934 1.2239135513462662 1.0475669546612947 1.0891825572820033 1.0550582927718926 1.177095098704381 1.1403613924619072 1.4263412044716266 1.2591943540032204 1.2325520527438134 1.0 17.664457812660324 -7.026297163487583 24.62212489492557 1.2557257164046243 1.1143856492768995 0.1740709231042521 0.1093630844201619 807.0854634573376 755674.4582692197 0.03991104542635025 0.0310307981514047 9.412453344550928e-08 7.026297163487583 -0.14134006712772473 S(ph)FNTSESK ddPTM_A459_Selumetinib_30min_R2 1 SFNTSESK 8 0 F5H7T0;F6RJM5;Q96S38-2;Q96S38;A0A087X1U5 F5H7T0 RPS6KC1 Ribosomal protein S6 kinase delta-1 1 S(0.975)FNT(0.012)S(0.012)ESK 106.36 0.013762 9347800.0 35607.0 23979.0 25434.0 33151.0 30443.0 26671.0 27842.0 31954.0 24230.0 23143.0 True False 33628.10548611461 25818.112195362577 23797.604130445397 28635.776611335248 26618.478176126926 30344.68815476775 29136.708167876353 32046.980849730542 29076.677042765685 22474.80145726469 1.4962581783006035 1.14875818789568 1.058857146110767 1.2741281237026947 1.1843698920651797 1.3501649041246244 1.2964167102111723 1.4259071836815613 1.2937456688128839 1.0 14.456020750555698 -6.7559165499952725 24.975619746060207 1.3013142063331822 1.2204921141533926 0.0 0.14841883730216315 416.93036268533467 1885460.1218114079 0.048426760209464854 0.04711903071400988 1.7542175436529966e-07 6.7559165499952725 -0.08082209217978953 S(ph)FQDYTGQK ddPTM_A459_Selumetinib_30min_R2 2 SFQDYTGQK 9 0 A0A087WXU5;A0A087WYV3;A0A0D9SEW3;A0A087WXF8;Q9NP64-2;Q9NP64-3;Q9NP64 A0A087WXU5 ZCCHC17 Nucleolar protein of 40 kDa 1 S(1)FQDYTGQK;S(1)FQDYTGQK 113.95 0.0088205 11332400.0 89036.0 76392.0 90693.0 95016.0 94283.0 81444.0 96161.0 99276.0 80729.0 94796.0 True False 84087.73555934792 82251.0207610051 84857.91111907219 82074.65688825778 82438.32663928566 92662.17172497851 100632.67703940668 99564.87672397334 96877.05575672438 92058.99317041282 0.9134114187376663 0.8934599209525144 0.9217775276119898 0.8915441507852169 0.8954945497468336 1.0065520872409406 1.093132496605985 1.0815334091224111 1.052336685644527 1.0 16.49027104374936 -6.905095680547319 3.4788554504149864 1.062741976728121 0.90280188743511 0.8937596225069719 0.02513515498659661 0.06671168838795456 1.5876447418610427 0.009153533779753857 0.007925748021594398 1.24424045971979e-07 6.905095680547319 -0.15994008929301096 S(ph)FRDLRNMS(ph)PRLT(ph)S(ph)R ddPTM_A459_Selumetinib_30min_R1 1 SFRDLRNMSPRLTSR 15 3 I3L257;I3L2E1 I3L257 CLUAP1 4 S(1)FRDLRNMS(1)PRLT(1)S(1)R 68.189 0.023139 74519000.0 63.096 150.2 58.499 163.27 55.06 49.51300000000001 128.34 157.16 0.0 0.0 True False 64.56601403655603 132.61451417391442 50.55515711200574 134.75795945747828 50.079832721632556 49.01494417420706 118.65921047287321 152.99160627237427 0.0 0.0 0.0 S(ph)FSADNFIGIQR ddPTM_A459_Selumetinib_30min_R2 2 SFSADNFIGIQR 12 0 Q8N7R7-3;Q8N7R7-2;Q8N7R7 Q8N7R7-3 CCNYL1 Cyclin-Y-like protein 1 1 S(0.995)FS(0.005)ADNFIGIQR;S(0.998)FS(0.002)ADNFIGIQR 167.03 0.00044619 7064500.0 20306.9 11563.2 15527.599999999999 19444.3 14355.099999999999 8032.1 22430.0 17857.3 12587.900000000001 13202.8 True False 19178.323792961524 12450.060258451835 14528.571121172605 16795.95279671158 12551.684001777734 9138.448866855759 23473.039444201822 17909.26178656483 15105.831735312831 12821.600859005926 1.4957823132897339 0.9710222924079625 1.133132381902818 1.3099731446494107 0.9789482717332756 0.7127385236327091 1.830741707086779 1.3968038767940056 1.1781548888805453 1.0 13.646288782470368 -7.254119334715372 24.99835821466073 1.3844921098085616 1.099903066247192 0.15983669068262385 0.2779910723519253 964.1781789175488 3292730.233418775 0.10711924345752505 0.08122470290567144 5.5703266739131833e-08 7.254119334715372 -0.2845890435613696 S(ph)FSEDTLMDGPAR ddPTM_A459_Selumetinib_30min_R1 4 SFSEDTLMDGPAR 13 0 Q9BRG2;M0QZQ6 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 S(1)FSEDTLMDGPAR;S(0.981)FS(0.017)EDT(0.002)LMDGPAR;S(0.985)FS(0.014)EDTLMDGPAR;S(1)FSEDTLMDGPAR 312.92 5.377399999999996e-88 43008900.0 4384.3099999999995 4339.68 4999.88 5453.68 4867.16 3851.3599999999997 4165.7 4291.83 2122.27 3357.68 True False 4486.455892617802 3831.5882481375 4320.923758374933 4501.297166252588 4426.92623736689 3812.618815155089 3851.477895175689 4177.996726571419 3601.3371855320047 3788.6709345728345 1.1841767126507232 1.0113278018349472 1.140485366238889 1.1880939896829812 1.1684641695771918 1.0063209186006952 1.0165775707860296 1.102760519116575 0.950554230685133 1.0 11.887476124515004 -6.7672747531343695 24.998395028654596 1.0217485971520297 1.1343084075863752 0.5251437788598247 0.05837642658766513 131.2223402749278 562145.2033904119 0.02072831903390042 0.018760033761288642 1.7089338289082432e-07 6.7672747531343695 0.11255981043434549 S(ph)FSEDTLMDGPAR ddPTM_A459_Selumetinib_30min_R2 3 SFSEDTLMDGPAR 13 0 Q9BRG2;M0QZQ6 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 S(0.981)FS(0.011)EDT(0.008)LMDGPAR;S(1)FSEDTLMDGPAR;S(0.999)FS(0.001)EDTLMDGPAR 227.06 6.6448e-13 12221900.0 19315.9 19648.6 21674.7 25676.1 25512.9 20003.3 20338.699999999997 17760.199999999997 20273.699999999997 22855.6 True False 18242.399605674193 21155.58443979319 20280.17339962902 22178.970886256968 22307.741413780117 22758.573003121943 21284.48985036949 17811.87924164061 24329.00649450758 22195.69944201958 0.8218889273270102 0.9531388949943471 0.9136983248762055 0.9992463154492467 1.0050479135407837 1.0253595775421596 0.9589465700763166 0.8024923606561467 1.0961135312748627 1.0 14.437992551858931 -3.8707685553692794 1.140541285658191 0.9736846999977775 4.1007923609503896e-10 0.28652746611550617 0.07265454257634195 15.04765345900306 3.4283019780968202 0.02181850356475958 28.703925628130346 0.00013465777823925336 3.8707685553692794 -0.9736846995876983 S(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R1 1 SFSEDVISHK 10 0 F8W9J4;Q03001;E9PHM6;F6QMI7;Q03001-8;Q03001-14;H0YC82;Q03001-10;A0A494C1D7 F8W9J4;A0A494C1D7 DST Dystonin 1 S(0.574)FS(0.425)EDVIS(0.001)HK 83.226 0.026904 8822000.0 5101.3 4514.8 5256.5 4980.5 4875.3 4702.0 5099.7 4476.2 2732.1 4401.6 True False 5220.150364598126 3986.205117126423 4542.696171887695 4110.749170563915 4434.329975804123 4654.702149074418 4715.025523207976 4357.476635253253 4636.174155311059 4966.588235214729 1.0510535839443178 0.8026043087008763 0.9146512569088169 0.8276806886098114 0.8928322151539115 0.9372031520694756 0.9493489896699929 0.8773581438375189 0.9334726246156412 1.0 12.278039426919717 -6.739907723534381 8.315919541305838 0.9324438515277357 0.8894347223495482 0.07545995084644763 0.06784374007987634 0.5174427135142814 162.6633125357651 0.021624115611148735 0.02114751264286868 1.8200875395623265e-07 6.739907723534381 -0.043009129178187444 S(ph)FSEDVISHK ddPTM_A459_Selumetinib_30min_R2 1 SFSEDVISHK 10 0 F8W9J4;Q03001;E9PHM6;F6QMI7;Q03001-8;Q03001-14;H0YC82;Q03001-10;A0A494C1D7 F8W9J4;A0A494C1D7 DST Dystonin 1 S(0.577)FS(0.415)EDVIS(0.008)HK 99.539 0.012162 3967200.0 41293.0 37500.0 36937.0 45942.0 39077.0 30286.0 36764.0 37395.0 35262.0 25069.0 True False 38998.10036897608 40376.12941849522 34560.51363396481 39684.6203456295 34167.797907187596 34457.62159106504 38473.598846484 37503.81325892448 42315.38530260023 24345.19283291573 1.6018809395606428 1.6584846830173794 1.4196031993321299 1.6300803455528277 1.4034720588037934 1.4153768190522147 1.5803365826893785 1.540501795008078 1.7381413075269645 1.0 14.571349307471728 -11.270565752398525 2.817460979665285 0.8935147993354657 1.547396726014141 0.7074559033936714 0.10683467163518516 41235266.63017835 36427205.74157746 30745745.70272962 0.026755580755592315 5.3633266426344236e-12 11.270565752398525 0.6538819266786753 S(ph)FSGNPR ddPTM_A459_Selumetinib_30min_R1 2 SFSGNPR 7 0 Q9NQS3-3 Q9NQS3-3 1 S(0.759)FS(0.241)GNPR;S(0.911)FS(0.089)GNPR 98.582 0.021764 155344000.0 17758.8 19093.9 20189.3 21575.8 19231.0 16138.5 18750.7 17001.8 10088.599999999999 14444.8 True False 18172.545487390496 16858.377311486707 17447.703951886662 17807.991557926493 17491.55944550882 15976.161342585588 17336.31960272483 16550.857034370405 17119.617357809417 16298.930784267028 1.1149532277866978 1.0343241243627894 1.0704815047578775 1.0925864888705537 1.0731722023381443 0.9801968947562498 1.06364766083056 1.0154566120586606 1.0503521724464637 1.0 13.992489705795343 -6.628548087236847 12.519944920966646 1.025516961004857 1.0754714536616827 0.47156156259197646 0.029063399394461262 0.4736913427405047 53.000866767551 0.009132327686604451 0.00913125581074253 2.3520790451243634e-07 6.628548087236847 0.04995449265682583 S(ph)FSISPVR ddPTM_A459_Selumetinib_30min_R2 1 SFSISPVR 8 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2;H7C2G8 P18583-10 SON Protein SON 1 S(0.999)FS(0.001)ISPVR 101.65 0.016863999999999997 1996600.0 11493.0 16331.0 12850.0 14984.0 14746.0 10895.0 12189.0 12401.0 11759.0 11175.0 True False 10854.265070124273 17583.53518755855 12023.244990022142 12943.153351158246 12893.475649087388 12395.6873550371 12755.812652045299 12437.084856903939 14111.128573911745 10852.348713863059 1.000176584471412 1.6202515834288396 1.1078933516634377 1.192659183041579 1.1880815839079095 1.142212407826754 1.1753964960369092 1.1460270200326772 1.3002833714591053 1.0 13.405719690527174 -14.522878745263196 0.13416254337438382 0.336581504985221 1.2884737778682338 0.11824505707421895 0.15727405387407725 286.631240160403 2.3884620156380034 51.817625962423485 1.045381240209366 3.000000000118413e-15 14.522878745263196 0.9518922728830128 S(ph)FSLDEPPLFIPDNIATIR ddPTM_A459_Selumetinib_30min_R1 4 SFSLDEPPLFIPDNIATIR 19 0 Q92576-2;Q92576;E7EVH3;D6R9X2;E9PE34;A0A1B0GX99 Q92576-2 PHF3 PHD finger protein 3 1 S(0.979)FS(0.021)LDEPPLFIPDNIATIR;S(0.984)FS(0.016)LDEPPLFIPDNIATIR;S(0.696)FS(0.304)LDEPPLFIPDNIATIR;S(0.999)FS(0.001)LDEPPLFIPDNIATIR 169.58 4.2652e-09 5534400.0 1529.016 1507.6399999999999 1552.1799999999998 1396.2199999999998 1283.42 1400.92 1654.6080000000002 1555.1100000000001 323.64 934.197 True False 1564.6390978527766 1331.1248079171785 1341.4024815144376 1152.3963872954018 1167.3348876062041 1386.8280167335884 1529.7995864274567 1513.8634310908112 549.193442269635 1054.1102847993673 1.484322011098279 1.2627946308014026 1.272544724074817 1.0932408154187983 1.1074124827729837 1.315638445741518 1.451270904465778 1.4361527943719385 0.5210018820508568 1.0 10.04181009946421 -8.25511438593609 24.999744625209242 0.7605009279248645 1.2924344205466363 0.6323816370977793 0.16527199243604848 297.63228923946804 1176413.0046130272 0.12062116462608925 0.04311047238030596 5.557578606241949e-09 8.25511438593609 0.5319334926217718 S(ph)FSLDEPPLFIPDNIATIR ddPTM_A459_Selumetinib_30min_R2 2 SFSLDEPPLFIPDNIATIR 19 0 Q92576-2;Q92576;E7EVH3;D6R9X2;E9PE34;A0A1B0GX99 Q92576-2 PHF3 PHD finger protein 3 1 S(0.999)FS(0.001)LDEPPLFIPDNIATIR;S(0.987)FS(0.013)LDEPPLFIPDNIATIR 132.9 0.00023774 3351500.0 4460.5 6892.4 6483.5 8180.4 7996.0 5821.0 4270.3 4764.7 4602.6 7240.200000000001 True False 4212.603266796251 7421.024917440967 6066.358668701057 7066.215408022887 6991.470994853031 6622.7899122231265 4468.877411438922 4778.564488161454 5523.248607388913 7031.156613701241 0.5991337554033962 1.0554486729793517 0.8627824697973397 1.0049862058616825 0.9943557481324087 0.941920408843923 0.6355821178453994 0.6796270870783506 0.7855391240505227 1.0 12.779546314443417 -7.23981516674494 24.100850155101085 0.7484893322222921 0.9224297869086135 0.15257941273960174 0.14841203089706229 717.8904303782642 800111.6223118606 0.05430583737798637 0.042019628345606116 5.7568489341546664e-08 7.23981516674494 0.17394045468632147 S(ph)FSLDPLMER ddPTM_A459_Selumetinib_30min_R1 1 SFSLDPLMER 10 0 Q63HR2-6;Q63HR2;Q63HR2-4;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(0.998)FS(0.002)LDPLMER 122.69 0.0043861 1639500.0 1884.3 1850.9 2197.2 1911.4 1952.3 1718.4 1783.9 1474.1 1105.6 1542.1 True False 1928.2005237904552 1634.195767539934 1898.8323083556822 1577.6098714217183 1775.7148097065603 1701.1144561823646 1649.3389867738704 1435.0020794483758 1876.1224501708966 1740.0435563260255 1.108133481360495 0.9391694602119148 1.0912556191207807 0.9066496443070229 1.0205002071648437 0.9776275139768014 0.9478722419203854 0.8246931947371924 1.0782043031912325 1.0 10.764907704361994 -1.5228787453190429 0.6268667954303403 0.9612015759817912 9.984251276373879 0.167845533813336 0.07729738438580917 342.04796448539327 2.40673955245298 0.03206872725073024 4259.0435940088255 0.029999999997326332 1.5228787453190429 9.023049700392088 S(ph)FSLDPLMER ddPTM_A459_Selumetinib_30min_R2 1 SFSLDPLMER 10 0 Q63HR2-6;Q63HR2;Q63HR2-4;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(0.816)FS(0.184)LDPLMER 125.74 0.0035753 953080.0 9491.3 11442.0 14085.0 15573.0 12951.0 11138.0 10213.0 12630.0 9375.3 12727.0 True False 8963.811542684285 12319.564608171266 13178.786434588483 13451.930535076584 11323.979596590998 12672.158399302727 10687.924736675574 12666.751208990945 11250.62196776892 12359.538441282799 0.7252545542270209 0.9967657503310954 1.0662846753701793 1.088384537900301 0.9162137931273492 1.0252938214080656 0.864751122175908 1.0248563301265368 0.9102784882475932 1.0 13.59333724731392 -4.760484091052547 24.978133007396554 0.9895084479969982 0.7252542402814174 0.5769452309648283 0.06751130598520153 17.113031768613737 447222.7635229801 0.01690743276885706 0.0999708865545561 1.7358648493963202e-05 4.760484091052547 -0.26425420771558084 S(ph)FSMHDLTTIQGDEPVGQRPYQPLPEAK ddPTM_A459_Selumetinib_30min_R1 1 SFSMHDLTTIQGDEPVGQRPYQPLPEAK 28 1 Q6NUK4 Q6NUK4 REEP3 Receptor expression-enhancing protein 3 1 S(0.474)FS(0.415)MHDLT(0.051)T(0.06)IQGDEPVGQRPYQPLPEAK 84.152 2.0598e-05 13005000.0 818.1 959.4 1213.5 1130.0 1206.8 828.81 1155.6 1072.6 371.25 985.63 True False 837.1601382545083 847.07300198704 1048.7133652783632 932.6667127270803 1097.6451530778445 820.4729238992692 1068.4321616211023 1044.1511637041776 629.9841349728157 1112.1452113492123 0.7527435533700653 0.761656835225144 0.9429644209914855 0.838619546448979 0.9869620818186351 0.7377390250180573 0.960694836176043 0.9388622574182135 0.56645852407038 1.0 10.119129455831425 -5.176129742266884 8.781105476943 0.8706524476249298 0.7560850364414674 0.11594012127661879 0.12629563842047895 0.7934870990884215 75.7074484433836 0.030534124187319465 0.08134456181200642 6.666075953715875e-06 5.176129742266884 -0.11456741118346236 S(ph)FSPLQPGQAPTGR ddPTM_A459_Selumetinib_30min_R1 1 SFSPLQPGQAPTGR 14 0 Q7Z3C6;H7C152;Q7Z3C6-2;H7C1G6 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 S(0.579)FS(0.421)PLQPGQAPTGR 160.04 0.00029369 11125000.0 1889.1 1951.5 1918.4 1909.8 1867.2 2032.3 1979.9 1749.4 836.13 1738.3 True False 1933.1123544512811 1723.0174727722638 1657.8918170169036 1576.289281385998 1698.3120896809342 2011.8569071807606 1830.5545489733643 1703.0002291479486 1418.8515414809972 1961.4277374758647 0.9855638918102473 0.8784506509475553 0.8452474620097005 0.8036438209110389 0.8658550387721494 1.0257104397686312 0.9332765688982663 0.8682452055763813 0.7233769128333519 1.0 10.937688469577163 -10.751497136612686 4.362769335529091 1.0000492828987035 0.8826040929834944 0.15922600601797754 0.08193616013467449 4.232516190922661e-05 7.483527110129661e-06 0.08324001781779407 0.02017997410788282 1.7721597292876226e-11 10.751497136612686 -0.11744518991520914 S(ph)FSPLQPGQAPTGR ddPTM_A459_Selumetinib_30min_R2 1 SFSPLQPGQAPTGR 14 0 Q7Z3C6;H7C152;Q7Z3C6-2;H7C1G6 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 S(0.72)FS(0.28)PLQPGQAPTGR 183.75 7.7435e-05 12566000.0 34534.0 27819.0 36478.0 36953.0 40654.0 30079.0 28926.0 30619.0 27475.0 34119.0 True False 32614.738530555267 29952.62784781648 34131.045194243416 31919.93765251943 35546.68106862873 34222.10922002397 30271.116315781623 30708.09622075168 32970.76771564121 33133.895818191835 0.9843315349790069 0.9039875060925159 1.0300945406940076 0.9633620455519785 1.0728192441865583 1.0328429052775214 0.9135996709195171 0.9267879753485464 0.9950767002031479 1.0 15.016020222182089 -10.576103179321038 21.008897661661624 0.9999692566849375 0.9797706879220143 0.012434104843349947 0.052402639279105406 0.0 0.0 0.05340649112731796 0.012952976706561436 2.6539749579108275e-11 10.576103179321038 -0.020198568762923252 S(ph)FSPTMK ddPTM_A459_Selumetinib_30min_R2 2 SFSPTMK 7 0 A3KN83-3;A3KN83-2;A3KN83;A3KN83-4 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 1 S(0.99)FS(0.009)PT(0.001)MK;S(0.865)FS(0.134)PT(0.001)MK 101.25 0.020043 137591000.0 876360.0 719270.0 971520.0 993630.0 1005630.0 639040.0 687240.0 771470.0 587860.0 744810.0 True False 827655.4195470391 774435.6961824284 909013.460910998 858295.8798926435 879293.7689537327 727061.9593724563 719198.0217402258 773714.8499762656 705448.4261807757 723305.4000512171 1.1442682710352128 1.0706897752008913 1.2567491696406954 1.1866299903635005 1.2156604511613907 1.0051936005468414 0.994321377511214 1.0696931751394072 0.9753119859617019 1.0 19.464245397006785 -6.768910047326519 24.999574990418065 1.0123484034589738 1.1742256646899822 0.7295235271122222 0.05048439748142249 96.93730401942358 324385.421548685 0.01836155362364688 0.01650284352790869 1.7025111022517287e-07 6.768910047326519 0.16187726123100843 S(ph)FTGGLGQLVVPSK ddPTM_A459_Selumetinib_30min_R1 2 SFTGGLGQLVVPSK 14 0 Q9Y3Q8 Q9Y3Q8 TSC22D4 TSC22 domain family protein 4 1 S(0.877)FT(0.123)GGLGQLVVPSK;S(0.956)FT(0.044)GGLGQLVVPSK 187.56 8.869200000000001e-05 90177000.0 5120.799999999999 6223.799999999999 7275.5 7234.3 7181.9 6022.1 6678.2 6676.9 3832.5 4842.5 True False 5240.1046766577265 5495.114602633875 6287.527061460841 5970.965309629665 6532.298413067432 5961.5231416293145 6174.457997350335 6499.8069223722005 6503.4725852749225 5464.082044944414 0.9590091498545634 1.005679372570581 1.1507014370837112 1.0927664080656037 1.1954978639296558 1.0910383651989914 1.1300082880459654 1.1895514871315083 1.1902223524063287 1.0 12.415763430981485 -5.157026105698461 3.4692338072360336 1.1367232105618543 0.9665075564144666 0.5205618327888932 0.05695335373270344 0.17412637658305224 3.822713343658497 0.014192371019936471 0.04612573106506521 6.965846407370497e-06 5.157026105698461 -0.1702156541473877 S(ph)FTGGLGQLVVPSK ddPTM_A459_Selumetinib_30min_R2 2 SFTGGLGQLVVPSK 14 0 Q9Y3Q8 Q9Y3Q8 TSC22D4 TSC22 domain family protein 4 1 S(0.886)FT(0.107)GGLGQLVVPS(0.007)K;S(0.98)FT(0.02)GGLGQLVVPSK 138.98 0.00057433 54274000.0 148360.0 127804.0 115366.0 164062.0 156720.0 101899.0 149245.0 138264.0 114566.0 99031.0 True False 140114.7451321359 137606.15584536974 107943.4771610035 141716.472577264 137031.4325054236 115934.66230297627 156185.18822335714 138666.3253491626 137482.40124149792 96171.71771656134 1.4569225595521136 1.430838079142192 1.1224035477783194 1.4735774294365087 1.4248620671337555 1.2054964292585535 1.6240241094961863 1.4418617930672921 1.4295512704336635 1.0 16.55332506658919 -10.51907553202303 4.882720641744748 0.9999958280652427 1.3985786855956759 0.44845750283399244 0.1334061977010214 7.275385708715577e-06 1.4957228288863894e-06 0.1293489259253058 0.031371328618863874 3.02638703639247e-11 10.51907553202303 0.3985828575304332 S(ph)FTLDDESLK ddPTM_A459_Selumetinib_30min_R1 2 SFTLDDESLK 10 0 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 S(0.876)FT(0.124)LDDESLK;S(0.987)FT(0.013)LDDESLK 202.65 0.00017045 125190000.0 7353.8 6563.3 6838.700000000001 5959.2 5434.6 6207.5 6512.0 6661.4 4784.200000000001 5148.5 True False 7525.129231996101 5794.86578480461 5910.042102290192 4918.537588038247 4943.0413895565625 6145.058185959049 6020.794597158723 6484.718032723296 8118.437975857092 5809.360125636824 1.295345626584166 0.9975050021828996 1.0173309924804035 0.8466573739046821 0.8508753602213126 1.0577857204687282 1.0363954836590066 1.1162534069984926 1.397475419027693 1.0 12.504163550803304 -7.865033725432387 3.185777784807789 1.2128348440939687 1.00122706132019 0.1958703497464992 0.14777159944147003 0.3529380853135318 6.975568852604281 0.09510052097464741 0.0406608101710809 1.3644771730748301e-08 7.865033725432387 -0.21160778277377879 S(ph)FTLDDESLK ddPTM_A459_Selumetinib_30min_R2 2 SFTLDDESLK 10 0 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 S(0.867)FT(0.133)LDDESLK;S(0.79)FT(0.204)LDDES(0.006)LK 168.85 0.00025321 34103000.0 128280.0 107179.0 110452.0 134094.0 122400.0 99457.0 142467.0 137627.0 127107.0 157129.0 True False 121150.71114552706 115399.2846651973 103345.638571045 115830.16587494749 107023.0177301163 113156.29896924518 149091.99779300505 138027.47178462357 152531.95166631497 152592.2774998287 0.7939504746278072 0.7562590096692596 0.6772665056471224 0.7590827515833987 0.7013658848511286 0.7415598012119075 0.9770612263990387 0.9045508334114649 0.99960465998344 1.0 17.219322425504295 -7.25819692997977 24.526207477941412 0.9623500916177331 0.735564872675649 0.8935769468813473 0.03918803015204031 66.10252299283019 500008.69453772414 0.01523344381521694 0.011296201112796419 5.518271575994723e-08 7.25819692997977 -0.22678521894208414 S(ph)FTPDHVVYAR ddPTM_A459_Selumetinib_30min_R1 1 SFTPDHVVYAR 11 0 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 S(0.607)FT(0.386)PDHVVY(0.007)AR 102.05 0.014669 24839000.0 2990.5 3480.1 3190.2 3385.8 2734.8 2482.9 2623.0 2490.0 2069.8 2684.1 True False 3060.1728314999486 3072.6482741454033 2756.988362514243 2794.533589337479 2487.4378228681558 2457.924280292825 2425.1449982105855 2423.957111340111 3512.2994277891817 3028.6303803480237 1.0104147575605777 1.0145339273101797 0.9103086267652886 0.922705394316343 0.8213078225089723 0.811562974551679 0.8007398373689658 0.8003476182067392 1.1596989353932252 1.0 11.564449804367868 -5.361445359702006 2.0262229089969757 0.8819938934588039 1.020858835833349 0.12294281389198058 0.10712347773174455 0.625912966003358 4.790721177769441 0.030707219052350177 0.1007661596367941 4.350654944896058e-06 5.361445359702006 0.13886494237454516 S(ph)FTPDHVVYAR ddPTM_A459_Selumetinib_30min_R2 4 SFTPDHVVYAR 11 0 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 S(0.928)FT(0.072)PDHVVYAR;S(0.987)FT(0.013)PDHVVYAR;S(1)FTPDHVVYAR;S(1)FTPDHVVYAR 185.3 2.0306e-05 79363100.0 222867.2 211144.0 266665.0 292103.0 301471.0 206701.0 238299.3 251378.0 239159.2 247220.8 True False 210481.1332320892 227338.0658650335 249508.06422289924 252318.06749421963 263597.5177950646 235172.18650514216 249380.6896311046 252109.46836213162 286997.72266637237 240082.89314722092 0.8767019193784054 0.9469148879575848 1.0392579869066252 1.0509622913428323 1.0979437740839966 0.9795457869667229 1.0387274426844821 1.0500934283874024 1.1954109637057018 1.0 17.873173083957155 -5.05490619391414 1.7521503297174557 1.0590310770480023 0.8591243312084451 0.5431232441964775 0.055232555224800854 0.42107827453046 1.910387935571087 0.015640371729535286 0.11801226874461651 8.812391970303703e-06 5.05490619391414 -0.19990674583955714 S(ph)FTSLYK ddPTM_A459_Selumetinib_30min_R1 1 SFTSLYK 7 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 S(1)FTSLYK 93.178 0.02605 11387000.0 1571.3 1963.8 1933.3 1915.8 1924.1 1543.1 1640.7 1599.7 1018.7 2001.2 True False 1607.9082327824337 1733.8773830541481 1670.7684788567442 1581.2414940199483 1750.0654947274447 1527.5778150226993 1516.9406780648521 1557.2707594420785 1728.6594970957783 2258.0735133387207 0.7120708087156242 0.7678569244145149 0.7399088067714834 0.7002613000326865 0.7750259167337071 0.6764960511688869 0.6717853378572908 0.6896457313028503 0.7655461555544458 1.0 11.140876739596209 -8.68314534360762 4.302972821001968 0.99999259466507 0.7179959255671353 0.8642530096037327 0.033538850669128005 0.5388584407567841 14.153865494749509 0.03465509098698372 0.009050861449696808 2.0742192305809165e-09 8.68314534360762 -0.28199666909793464 S(ph)FTSLYK ddPTM_A459_Selumetinib_30min_R2 1 SFTSLYK 7 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 S(0.982)FT(0.018)SLYK 88.177 0.03262 8914700.0 35482.0 28590.0 30367.0 30805.0 30213.0 25043.0 32332.0 29023.0 30802.0 28541.0 True False 33510.05248569994 30782.76106866076 28413.220281089696 26609.305858410982 26417.37283235302 28492.445932280316 33835.502064642584 29107.452124983705 36963.26067978823 27716.94717157635 1.2090095015970734 1.110611528683375 1.025120844124831 0.9600373985522745 0.953112645083942 1.0279792271458827 1.2207514000438258 1.0501680414080132 1.3335978327979046 1.0 14.758480742978037 -7.243530924366334 23.97069957243527 1.1553099904623974 1.0412043464302725 0.17579794601958487 0.10908844757499803 801.6958586546297 1073081.3191543464 0.041993513032320906 0.032444145098943465 5.7078043174199916e-08 7.243530924366334 -0.11410564403212486 S(ph)FVDAEVDVTR ddPTM_A459_Selumetinib_30min_R1 2 SFVDAEVDVTR 11 0 A0A2R8YHB3;A0A1B0GUB2;A0A3B3IRP5;Q6P1J9 A0A2R8YHB3 CDC73 Parafibromin 1 S(1)FVDAEVDVTR;S(1)FVDAEVDVTR 204.85 2.3238e-27 3371000.0 1031.91 1146.6100000000001 889.48 1099.29 1139.4499999999998 801.45 1135.2800000000002 1120.04 714.62 800.48 True False 1055.9514952526704 1012.3643681554726 768.6935015639046 907.319637728985 1036.3869486862366 793.3881406583771 1049.6449155808284 1090.332900797341 1212.6579462202658 903.2294053354887 1.1690844972661798 1.120827513116059 0.8510501285976037 1.0045284535349877 1.1474238355883564 0.8783905129435938 1.1621022404501504 1.2071494731644128 1.342580233833115 1.0 9.818948644708847 -7.498892704068477 21.982024891927985 1.2018442157253622 1.028259821779396 0.25119798218312017 0.1255402532358891 205.68303898340486 188500.04457522405 0.05263134473514019 0.03516645133118548 3.17035062682074e-08 7.498892704068477 -0.17358439394596625 S(ph)FVDAEVDVTR ddPTM_A459_Selumetinib_30min_R2 1 SFVDAEVDVTR 11 0 A0A2R8YHB3;A0A1B0GUB2;A0A3B3IRP5;Q6P1J9 A0A2R8YHB3 CDC73 Parafibromin 1 S(1)FVDAEVDVTR 117.2 0.0056675 948070.0 1292.9 2310.6 2766.9 3209.8 2065.7 1839.4 2549.4 2500.8 2639.7 2580.9 True False 1221.0457938887732 2487.8155902500007 2588.8806663729383 2772.619702786156 1806.1882984076922 2092.7606535892846 2667.9521515402625 2508.076913970273 3167.713759380461 2506.3827110164825 0.4871745198855002 0.9925920647773093 1.0329151469940512 1.106223598893921 0.7206354761660396 0.8349725061503276 1.0644631962284221 1.0006759554102986 1.263858765645479 1.0 11.291391007833193 -7.321347795800312 5.85631491448646 1.0848013164495383 0.8808542584051866 0.2652824187087863 0.17770609509142796 0.36054858945381646 25.967563839300144 0.07715412285707632 0.05185590759407334 4.77147007249473e-08 7.321347795800312 -0.20394705804435165 S(ph)FVLNLGK ddPTM_A459_Selumetinib_30min_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 1 S(1)FVLNLGK 99.568 0.018546 7509700.0 5097.2 6805.3 6409.8 6820.2 6030.6 5769.6 5781.4 5331.9 3049.0 4849.1 True False 5215.954842575336 6008.5323123018625 5539.384366511126 5629.18010100994 5485.133294788909 5711.563062377655 5345.304343368156 5190.4806915479285 5173.9303098508135 5471.52921923386 0.9532901376529046 1.098144974019383 1.0124014959179488 1.0288129470682337 1.0024863388295957 1.0438696082075214 0.976930603710935 0.9486343732392084 0.9456095549418052 1.0 12.417728388004438 -7.407668493549119 4.622876473541328 0.9606870748845554 1.0252254473712015 0.3529726735912767 0.03672727288869595 0.22560690809182962 7.576480199909731 0.015180907192593109 0.009919423687132056 3.911393470658858e-08 7.407668493549119 0.06453837248664607 S(ph)FVLNLGK ddPTM_A459_Selumetinib_30min_R2 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 1 S(1)FVLNLGK 88.134 0.031496 3337000.0 29454.0 25325.0 27832.0 29412.0 29295.0 22106.0 23333.0 22030.0 19147.0 23711.0 True False 27817.06459370403 27267.34606729043 26041.319421190383 25406.034861469994 25614.700199377137 25150.90084171181 24418.030733462383 22094.103652737183 22976.93501187925 23026.40182142346 1.2080508630672553 1.184177461974161 1.13093307513473 1.1033436773361853 1.1124056810102896 1.0922636127330907 1.0604362298040058 0.9595117736624018 0.9978517351548088 1.0 14.491001368189789 -6.491709763761447 0.4507932693886918 0.9720760446031201 1.2205765543302667 0.8832077716302211 0.026338665355692792 0.46739704169683083 0.18846152497988164 0.026920041591049024 0.051199482015624846 3.2232221305101655e-07 6.491709763761447 0.24850050972714655 S(ph)FVPEEEKHEER ddPTM_A459_Selumetinib_30min_R2 2 SFVPEEEKHEER 12 1 A0A0U1RRH6;O94880;O94880-2;B4DG57 A0A0U1RRH6 PHF14 PHD finger protein 14 1 S(1)FVPEEEKHEER;S(1)FVPEEEKHEER 110.25 0.0031243 8525400.0 78091.0 73991.0 69679.0 76708.0 68370.0 62116.0 85885.0 111740.0 98355.0 126708.0 True False 73751.01484304147 79665.87178143687 65195.92900075904 66260.23807131911 59780.74936444497 70671.91516709368 89878.822677899 112065.14490044721 118028.74826831298 123049.61081307934 0.5993600008623695 0.6474288805549715 0.5298344998408492 0.5384839304528389 0.485826399363879 0.5743367630349444 0.7304275249958408 0.9107314046745074 0.95919643701764 1.0 16.908880569218432 -7.623637014822544 1.8677954026868024 0.9770259236454675 0.5584046365696664 0.9474837019870281 0.04175915151172717 0.08210589305141017 0.56335952027002 0.031617340955576154 0.014495299255100546 2.378827690282949e-08 7.623637014822544 -0.41862128707580104 S(ph)GAEVEAGDAAER ddPTM_A459_Selumetinib_30min_R1 2 SGAEVEAGDAAER 13 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67;Q8IY67-3;K7EKR9 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 S(1)GAEVEAGDAAER;S(1)GAEVEAGDAAER 132.24 0.0014429 12648400.0 2478.1499999999996 2448.42 2283.31 2599.67 2292.94 1640.33 2180.59 2122.2200000000003 1279.03 2069.28 True False 2535.8860733595034 2161.757848160423 1973.2490433240553 2145.6864363497425 2085.5439818514374 1623.829769500476 2016.1063406969186 2065.9318316579165 2170.4204933448646 2334.8922444940795 1.0860827001072055 0.925849085009415 0.845113537028179 0.9189659357554919 0.8932078072422265 0.6954624023141268 0.8634686870244691 0.884808211826306 0.929559168506788 1.0 11.189140255615794 -4.780134737095049 2.6583318565333105 0.8696057575792009 1.1303711144441058 0.4082610950375042 0.07410644572557815 0.46129772628096893 4.295979711999301 0.019425170360061552 0.27235681914390913 1.6590721110371294e-05 4.780134737095049 0.2607653568649049 S(ph)GAEVEAGDAAER ddPTM_A459_Selumetinib_30min_R2 2 SGAEVEAGDAAER 13 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67;Q8IY67-3;K7EKR9 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 S(1)GAEVEAGDAAER;S(1)GAEVEAGDAAER 163.62 0.00036297 20393400.0 10595.0 17810.7 15841.5 14975.199999999999 16231.0 21837.4 12990.8 16912.9 18157.9 15089.0 True False 10006.172315145452 19176.723419573143 14822.27513692107 12935.551926339092 14191.916673018957 24845.30362981984 13594.897940781846 16962.11373891869 21789.987374116165 14653.341364069782 0.6828594288863522 1.3086928737355947 1.0115286860965047 0.8827714856938544 0.9685106161395896 1.69553844495433 0.9277677768510016 1.1575594478751485 1.4870319903653886 1.0 13.838942055781985 S(ph)GASAAPAASAAAALAPSATR ddPTM_A459_Selumetinib_30min_R2 2 SGASAAPAASAAAALAPSATR 21 0 A0A0M3HER2;Q7Z7K6-3 A0A0M3HER2 1 S(1)GASAAPAASAAAALAPSATR;S(1)GASAAPAASAAAALAPSATR 204.51 3.6142e-17 11616000.0 18135.7 16680.9 19356.5 17461.4 19580.3 19327.0 17416.8 16511.1 14908.4 19752.3 True False 17127.790396959266 17960.271392452712 18111.12386376371 15083.127197404872 17120.44766389706 21989.118816962105 18226.715710734472 16559.144567440246 17890.496575500114 19181.999776361296 0.8929095295927639 0.9363086019105179 0.9441728743049373 0.7863167226178566 0.8925267367063175 1.1463413133838178 0.9501989325010807 0.8632647669950818 0.9326710866479756 1.0 14.227465512681613 -6.582169431203777 24.99999321554563 0.9738755264301601 0.8898973073991091 0.24088546516122922 0.07794736792563763 128.82116878899987 54316.36902482146 0.027538804617733687 0.02753880713320084 2.617161776319038e-07 6.582169431203777 -0.08397821903105096 S(ph)GASEANLIVAK ddPTM_A459_Selumetinib_30min_R1 4 SGASEANLIVAK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.987)GAS(0.013)EANLIVAK;S(0.994)GAS(0.006)EANLIVAK;S(1)GASEANLIVAK;S(0.96)GAS(0.04)EANLIVAK 168.67 0.00037887 42758700.0 6562.6 10692.4 9107.2 9471.5 8441.2 8042.3 10340.099999999999 8250.2 4133.849999999999 6884.2 True False 6715.495811403302 9440.528837238098 7870.492262268739 7817.480327074815 7677.694950414904 7961.401763824157 9560.137932137723 8031.377895573569 7014.841525541746 7767.854127786541 0.8645239342717794 1.2153329197401121 1.0132131902574033 1.006388662618001 0.9883932967987741 1.0249164869542635 1.230730878163632 1.033924912009402 0.9030604089807532 1.0 12.923300393362684 -8.108905335092576 6.87406528006546 0.9540621067428673 1.0548166278193498 0.11960038890858915 0.10347272371329595 0.5072076970824151 27.839370608694505 0.06929252868397173 0.025846681334630812 7.782061612672481e-09 8.108905335092576 0.10075452107648253 S(ph)GASEANLIVAK ddPTM_A459_Selumetinib_30min_R2 2 SGASEANLIVAK 12 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.99)GAS(0.01)EANLIVAK;S(1)GASEANLIVAK 154.6 0.000438 34240000.0 76743.0 65655.0 83813.0 77578.0 75805.0 69614.0 66984.0 93454.0 66974.0 88621.0 True False 72477.93128656977 70690.5273859013 78420.56282869483 67011.74257048537 66281.69819470156 79202.69660702646 70098.88872627793 93725.93566785748 80370.67140991287 86062.28146498946 0.8421567503535696 0.8213880248417367 0.9112071106387842 0.7786424137239036 0.77015966886336 0.9202951079009739 0.8145134841073728 1.089047769503829 0.9338663819016702 1.0 16.393093465415483 -7.749306897949466 24.99659745938431 1.0085928117326537 0.8375684411238116 0.6481356805150268 0.057643622314843254 126.82069646498401 261290.43715481076 0.026629495027211115 0.015225353396101217 1.7811196790113223e-08 7.749306897949466 -0.17102437060884212 S(ph)GCCDDSALAR ddPTM_A459_Selumetinib_30min_R2 2 SGCCDDSALAR 11 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 S(0.999)GCCDDS(0.001)ALAR;S(1)GCCDDSALAR 125.54 0.0033299 19073200.0 18481.5 17612.0 22963.8 25386.2 23877.7 19630.6 19692.5 21863.6 21676.6 18384.7 True False 17454.37221730635 18962.783768494344 21486.334109094973 21928.555766362362 20877.969856653614 22334.536961155693 20608.240269948463 21927.21945628617 26012.525694808697 17853.885941812827 0.9776231501753444 1.0621096062949824 1.2034542048224444 1.2282231351667192 1.1693795919104955 1.2509622293962026 1.1542719796190188 1.2281482881513104 1.4569671711573322 1.0 14.123950494074613 -5.107107583965045 2.1606485214673885 1.2205006695882423 0.9715892590276229 0.3536647925823976 0.1061991028218828 0.39846174111779015 3.188054074745118 0.027960586059358482 0.14642392212048488 7.814342027645559e-06 5.107107583965045 -0.24891141056061938 S(ph)GCSDLEEAVDSGADKK ddPTM_A459_Selumetinib_30min_R2 1 SGCSDLEEAVDSGADKK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 S(0.841)GCS(0.159)DLEEAVDSGADKK 70.615 0.016214 14553000.0 43846.0 33911.0 40234.0 40121.0 45383.0 38318.0 44931.0 45658.0 26244.0 50520.0 True False 41409.214849444805 36511.86465894912 37645.38824346702 34656.4505874146 39681.58181083231 43595.95668382852 47020.38052908747 45790.85722091123 31493.5333186274 49061.35633327626 0.8440291492992964 0.7442082198242174 0.7673124238094848 0.7063899813937387 0.8088154257553202 0.8886007224846985 0.9583995234390926 0.9333385915760591 0.6419213750368059 1.0 15.582299498244048 -6.616800387896308 3.971944080819216 0.8846023305475493 0.763328321878313 0.25979320880143886 0.09506139841029385 0.3159375668785226 9.41812030353497 0.03211461224333337 0.03217916060502547 2.4165712930407596e-07 6.616800387896308 -0.12127400866923632 S(ph)GDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_A459_Selumetinib_30min_R1 1 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 S(0.999)GDAAIVDMVPGKPMCVES(0.001)FS(0.001)DYPPLGR 53.987 0.0051887 5025300.0 646.28 649.0 645.65 817.55 947.84 662.82 806.29 731.71 422.32 502.57 True False 661.3370665580297 573.0147782880857 557.9742763015869 674.7802398141814 862.108039354744 656.1526325924082 745.470896152197 712.3026738709527 716.646194967595 567.079754946353 1.1662152647657007 1.0104659411484267 0.9839432133393168 1.1899212305295876 1.5202588909849222 1.1570729282241468 1.3145785749708527 1.2560890556537998 1.2637485092998801 1.0 9.147407842003886 -5.957659113077038 6.836185730105657 1.2712490789460344 1.0534382951641696 0.30976530018313553 0.13049092389885353 0.20695904521513714 25.02540258039756 0.03525394155506572 0.052256785815373324 1.102404270458605e-06 5.957659113077038 -0.2178107837818648 S(ph)GDDLFPK ddPTM_A459_Selumetinib_30min_R1 3 SGDDLFPK 8 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 S(1)GDDLFPK;S(1)GDDLFPK;S(1)GDDLFPK 100.25 0.017997 9165900.0 8414.6 10017.199999999999 8774.1 9239.8 9352.5 9665.3 11560.0 13259.8 5294.17 9914.6 True False 8610.643808038609 8844.381567130064 7582.625412681409 7626.2423825271535 8506.568026317986 9568.075857390251 10688.01989299061 12908.107030099438 8983.81981912197 11187.235486382211 0.7696846838095088 0.7905779383920172 0.6777925987087199 0.6816914144526843 0.7603816006798733 0.8552672256731433 0.9553763220592543 1.1538245570866885 0.8030419874559382 1.0 13.449565950909935 -7.019783079937755 2.1560058994857254 0.9927516801565293 0.7308321970925089 0.6397062790258645 0.08570441817863893 0.19324176949203276 1.7961247667859683 0.036729613126381386 0.028377865424290195 9.554697019037065e-08 7.019783079937755 -0.26191948306402035 S(ph)GDDLFPK ddPTM_A459_Selumetinib_30min_R2 2 SGDDLFPK 8 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 S(1)GDDLFPK;S(1)GDDLFPK 101.38 0.017079 5177900.0 65270.0 47141.0 57664.0 63034.0 63602.0 53800.0 72677.0 78954.0 57069.0 61744.0 True False 61642.5546965119 50756.56311779418 53953.96101981608 54448.66046028492 55611.748150905754 61210.46165222542 76056.62450674352 79183.7430684616 68484.39464108935 59961.29028982205 1.028039163242877 0.8464888409249209 0.8998132088057207 0.9080635222675845 0.9274608315149183 1.0208329633396067 1.2684287502674627 1.3205810396295359 1.1421434447135979 1.0 15.871743808110388 -7.056200517554514 3.4118283014967403 1.2082480108683709 0.9175376202635839 0.6409740471838951 0.09096506900734305 0.13821624441475316 3.199110700417545 0.03531496555550321 0.02771110463574663 8.786167581376934e-08 7.056200517554514 -0.290710390604787 S(ph)GDEEFKGEDELCDSGR ddPTM_A459_Selumetinib_30min_R1 4 SGDEEFKGEDELCDSGR 17 1 O43823;M0QYL4 O43823 AKAP8 A-kinase anchor protein 8 1 S(1)GDEEFKGEDELCDSGR;S(0.964)GDEEFKGEDELCDS(0.036)GR;S(1)GDEEFKGEDELCDSGR;S(1)GDEEFKGEDELCDSGR 114.28 0.0082112 71155000.0 7686.2 8784.2 6162.0 5195.74 6895.799999999999 7497.700000000001 10799.8 12270.8 7051.01 13203.5 True False 7865.273505258284 7755.741780336211 5325.234245443159 4288.401545119114 6272.076107552372 7422.279945366921 9985.162391031135 11945.338522824184 11965.04898460518 14898.297837981112 0.5279310153947169 0.520579053035444 0.3574391050142134 0.28784506738658683 0.42099279902718806 0.49819650715029096 0.6702216924120936 0.8017921679865485 0.8031151689088919 1.0 13.86285988869443 -7.620011144402284 1.0979156633648444 0.9289842824576234 0.4132602942310938 0.8713279762267323 0.07658586391474179 0.19180980151260443 0.4236396362942361 0.07044782011961095 0.030462827365526392 2.398771363514703e-08 7.620011144402284 -0.5157239882265297 S(ph)GDEEFKGEDELCDSGR ddPTM_A459_Selumetinib_30min_R2 4 SGDEEFKGEDELCDSGR 17 1 O43823;M0QYL4 O43823 AKAP8 A-kinase anchor protein 8 1 S(1)GDEEFKGEDELCDSGR;S(1)GDEEFKGEDELCDSGR;S(1)GDEEFKGEDELCDSGR;S(1)GDEEFKGEDELCDSGR 129.05 0.004593600000000001 140698100.0 291014.0 169324.0 174617.0 229224.0 228915.0 225252.9 338523.0 305803.0 223640.0 172842.3 True False 274840.6069013439 182310.60633752728 163382.3323286144 198003.29576654435 200156.65117393457 256279.44233276122 354264.9902705987 306692.8361015882 268374.2490236945 167851.89370077223 1.6373995004864188 1.0861397051768176 0.9733719931684198 1.1796309913519516 1.1924598928311867 1.5268188918358456 2.1105808368307306 1.8271633958942772 1.5988753126736979 1.0 17.356829288012648 -6.881667890551088 4.039503348110427 1.7163273496725349 1.1914461494212853 0.2802761096467038 0.30936709494163966 0.23386231601874916 6.9857069198538575 0.11043891063685748 0.09704239471025901 1.3132037355265527e-07 6.881667890551088 -0.5248812002512495 S(ph)GDEMIFDPTMSK ddPTM_A459_Selumetinib_30min_R1 1 SGDEMIFDPTMSK 13 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 S(1)GDEMIFDPTMSK 241.42 4.9675e-65 0.0 3278.1 3596.5 4053.2 4708.2 3406.4 3165.9 3366.3 3103.9 1897.1 2732.6 True False 3354.473351927765 3175.420108032511 3502.79770263392 3886.001253859857 3098.291721448765 3134.053920407208 3112.3772807763203 3021.574489111876 3219.2401412981244 3083.355827778029 1.0879293663440437 1.0298584676556215 1.1360342102189858 1.2603155363551541 1.0048440382832817 1.0164425046802703 1.0094122944672284 0.979962955261419 1.044070266654244 1.0 11.590285674706777 S(ph)GDETPGSEVPGDK ddPTM_A459_Selumetinib_30min_R1 3 SGDETPGSEVPGDK 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.601)GDET(0.399)PGSEVPGDK;S(0.96)GDET(0.04)PGSEVPGDK;S(0.998)GDET(0.002)PGSEVPGDK 157.37 0.00031379 190729000.0 16345.099999999999 18307.300000000003 14194.5 13132.800000000001 15192.4 14472.1 18245.7 19246.899999999998 10002.9 19864.3 True False 16725.90902797184 16163.872805167124 12266.96486480736 10839.403013187792 13818.250102436074 14326.523813615444 16869.412159302658 18736.409689257816 16974.190717089772 22414.076399667396 0.7462234325309981 0.7211482872168216 0.5472884381258463 0.48359802206030844 0.6164987508760844 0.6391752913730604 0.7526257990069573 0.8359215590759674 0.7573004755771089 1.0 14.45211743209119 -8.148152236637406 0.730916538081397 0.9771176117674715 0.6148727054427 0.6493006798579716 0.08310607141527636 0.4314156717760085 0.4952231965943099 0.08813766925155082 0.037112703263828165 7.1096425011516e-09 8.148152236637406 -0.36224490632477147 S(ph)GDETPGSEVPGDK ddPTM_A459_Selumetinib_30min_R2 3 SGDETPGSEVPGDK 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.998)GDET(0.002)PGSEVPGDK;S(1)GDETPGSEVPGDK;S(1)GDETPGSEVPGDK 219.84 8.537399999999999e-09 647570000.0 372311.0 230948.0 311127.0 338866.0 331572.0 304855.0 436526.0 458489.0 370809.0 240404.0 True False 351619.44509902044 248660.96898513712 291109.42754946486 292711.8662235446 289916.9610687103 346846.0090518436 456825.3239598594 459823.12708306045 444981.1612691243 233462.9118753945 1.506104084261098 1.0650983789573147 1.2469193723791034 1.253783154986831 1.2418116382590434 1.4856578557409785 1.9567361697419394 1.9695767665593094 1.9060036461235559 1.0 17.832833854764502 -7.008662273355343 3.7321515662540463 1.7869415559363644 1.2534333536853857 0.34091050860389804 0.28252848232987104 0.20927597744662435 6.382461468772419 0.10348802097205813 0.08422709093732374 9.80251976490109e-08 7.008662273355343 -0.5335082022509787 S(ph)GDETPGSEVPGDKAAEEQGDDQDSEK ddPTM_A459_Selumetinib_30min_R1 1 SGDETPGSEVPGDKAAEEQGDDQDSEK 27 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.978)GDET(0.017)PGS(0.005)EVPGDKAAEEQGDDQDSEK 107.58 9.9694e-10 18676000.0 1229.4 769.03 1219.7 1360.6 680.25 912.93 1069.9 1100.0 810.39 891.23 True False 1258.0426280040251 678.9916100876527 1054.0714393325252 1122.996751625191 618.721507607892 903.7467530741187 989.196581618568 1070.8244266964346 1375.1726414562154 1005.6280518153447 1.2510019243526722 0.6751915967956017 1.0481722714772437 1.1167118395295101 0.6152587992061133 0.8986888854608706 0.9836604894154305 1.0648314998407198 1.3674764133456443 1.0 9.97388108381559 -7.865183645169688 2.909298261316486 1.1903751151481938 0.9250115842164536 0.19197161582842726 0.19739067159869472 0.3863463572458073 6.417517299778793 0.1265633555057185 0.05270964955618698 1.364006232816061e-08 7.865183645169688 -0.26536353093174025 S(ph)GDETPGSEVPGDKAAEEQGDDQDSEK ddPTM_A459_Selumetinib_30min_R2 2 SGDETPGSEVPGDKAAEEQGDDQDSEK 27 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.951)GDET(0.029)PGS(0.02)EVPGDKAAEEQGDDQDSEK;S(0.976)GDET(0.024)PGSEVPGDKAAEEQGDDQDSEK 107.13 1.0608e-09 27052000.0 70640.0 81868.0 68384.0 68260.0 54533.0 35471.0 25464.6 21214.1 11280.8 64625.0 True False 66714.1115943251 88147.01235288964 63984.24789086953 58962.87024493202 47682.07700879445 40356.80827632135 26648.754357147645 21275.82951881668 13537.275211887365 62759.10833408504 1.0630187930521007 1.404529393305867 1.0195213027926195 0.939510961995436 0.7597634554488704 0.6430430474169628 0.42461970962507234 0.3390078362101519 0.21570215975384005 1.0 15.937537234546154 -6.287255458969185 0.9993951636425413 0.44397682202246275 1.229926029861018 0.630010262467663 0.21588891209811345 0.31398028781818177 0.663553593119196 0.09701897545944821 0.1468701659282088 5.161126942156309e-07 6.287255458969185 0.7859492078385553 S(ph)GDLGDMEPLK ddPTM_A459_Selumetinib_30min_R2 2 SGDLGDMEPLK 11 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 S(1)GDLGDMEPLK;S(1)GDLGDMEPLK 162.32 0.00062374 13474100.0 91154.0 61894.0 80718.0 80152.0 82142.0 80992.0 108889.0 111862.0 93429.0 66556.0 True False 86088.02559837372 66641.07077942244 75524.6917591134 69235.15933008782 71822.5876012028 92147.91282782597 113952.5542594603 112187.49990024892 112117.41062437295 64634.35534674446 1.331923636223129 1.0310471949772306 1.1684914524782597 1.0711820201294093 1.1112137997802496 1.4256800788602177 1.7630338176676799 1.7357255177744981 1.7346411211637487 1.0 15.98001358956917 -6.925142309819092 3.6503994728158085 1.6187817965859002 1.1345792564344792 0.43412346776571165 0.22107689965818292 0.18273462270572968 4.852783923036471 0.0781182231592624 0.06718862166601396 1.1881128422713197e-07 6.925142309819092 -0.48420254015142095 S(ph)GDVLAK ddPTM_A459_Selumetinib_30min_R2 1 SGDVLAK 7 0 P85299;P85299-5;P85299-2;P85299-4;P85299-3;B1AHG4 P85299 PRR5 Proline-rich protein 5 1 S(1)GDVLAK 96.668 0.023938 0.0 27803.0 24468.0 23035.0 24229.0 30277.0 16113.0 35131.0 39702.0 20797.0 25525.0 True False 26257.82056422738 26344.61692297975 21552.953178611686 20928.968402643713 26473.33258018576 18332.419490749224 36764.66111075586 39817.526246980095 24956.981116731233 24788.026928085448 1.0592944989291027 1.0627960425979144 0.8694904697796523 0.8443176402608581 1.0679886970023749 0.7395675155563971 1.483162061160285 1.6063209210841163 1.0068159595411104 1.0 14.59735582022166 -7.265681024944784 24.994538826528117 1.3246014801999575 0.944316246835831 0.38443287182899066 0.2027151046314518 340.1734932393323 2004512.9996526188 0.08104215699032569 0.05682891800333596 5.423991185067253e-08 7.265681024944784 -0.38028523336412645 S(ph)GDYSTMEGPELR ddPTM_A459_Selumetinib_30min_R1 2 SGDYSTMEGPELR 13 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 S(1)GDYSTMEGPELR;S(1)GDYSTMEGPELR 239.38 9.6992e-18 13796400.0 922.5 1371.6 1243.73 1015.04 1304.31 1027.04 1234.56 1034.06 674.8 864.51 True False 943.9924551274709 1211.0124343604593 1074.8382973198666 837.782318660616 1186.3353907946337 1016.7089100777092 1141.4361452500411 1006.6333696997408 1145.0863145579958 975.4782795405046 0.9677226801729866 1.24145504801081 1.101857744927099 0.8588426172392586 1.2161576691932623 1.0422670923607096 1.1701297396265045 1.0319382715255452 1.1738716674423386 1.0 9.929965939238377 S(ph)GDYSTMEGPELR ddPTM_A459_Selumetinib_30min_R2 2 SGDYSTMEGPELR 13 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 S(1)GDYSTMEGPELR;S(1)GDYSTMEGPELR 177.36 0.00010376 7872500.0 13285.4 13585.199999999999 14589.8 18186.5 17910.9 15488.5 13609.9 14585.599999999999 16200.8 14983.1 True False 12547.050653669976 14627.141156697093 13651.108152173158 15709.467326537606 15660.772616522403 17621.900284395804 14242.78731750523 14628.041681223936 19441.41268817325 14550.498972231026 0.8623106793530214 1.0052673234514042 0.9381883176807672 1.0796514508896513 1.0763048501917554 1.211085634796883 0.9788521579010417 1.0053292130490437 1.3361337453290307 1.0 13.828781007076145 -5.799525357528076 3.9492554115569187 1.0993286638441577 0.9401083744944304 0.33134964704548264 0.10620014598016599 0.2648324292804806 8.742227784575778 0.029843769455261945 0.048396516056129234 1.5866262765243534e-06 5.799525357528076 -0.15922028934972732 S(ph)GECSPVPMGSFPR ddPTM_A459_Selumetinib_30min_R2 1 SGECSPVPMGSFPR 14 0 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7;E7EMH9 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.566)GECS(0.434)PVPMGSFPR 129.37 0.0010585999999999998 4735300.0 22696.0 22578.0 30807.0 32496.0 34611.0 19804.0 20114.0 21945.0 21858.0 21192.0 True False 21434.647179286578 24309.660000287608 28824.91116012548 28069.988741273257 30262.856753734148 22531.82123718722 21049.340855134866 22008.85631680967 26230.21076354817 20580.131896571453 1.0415213705631052 1.1812198348610912 1.4006183879184744 1.3639362897353238 1.470488960217781 1.0948336653246091 1.0227991230047258 1.0694225103812982 1.2745404594767438 1.0 14.328964607938754 -6.849817383122078 13.371285699778662 1.0920638271337004 1.2954810411046733 0.3670472532729405 0.1307693560257791 0.887730819951789 130.69314378802346 0.04916912810450138 0.043365646352980694 1.413131628702074e-07 6.849817383122078 0.2034172139709729 S(ph)GEGEVSGLMR ddPTM_A459_Selumetinib_30min_R1 2 SGEGEVSGLMR 11 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 S(1)GEGEVSGLMR;S(1)GEGEVSGLMR 198.32 1.9372e-05 76550000.0 2894.1 2525.0 2304.1000000000004 2302.86 2477.3 2158.9 2450.5 2355.7 1425.94 2491.5 True False 2961.5268990616973 2229.371826159346 1991.2158755153496 1900.7087310360043 2253.2286524028373 2137.183426124362 2265.656812091131 2293.219183607991 2419.716033462994 2811.308294265154 1.05343370028217 0.7930015468979648 0.708287980929474 0.676094021745427 0.8014875696839244 0.7602095545636339 0.8059083440663165 0.8157124525566891 0.8607081757625169 1.0 11.457025956174402 -8.727551182500797 1.2135338988022892 0.9997221930587161 0.7894544622671432 0.2830288557627032 0.09506168828909767 1.0150649444079929 2.900862512566485 0.09357133254192876 0.02871323956798348 1.872616378308492e-09 8.727551182500797 -0.2102677307915729 S(ph)GEGEVSGLMR ddPTM_A459_Selumetinib_30min_R2 2 SGEGEVSGLMR 11 0 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 S(1)GEGEVSGLMR;S(1)GEGEVSGLMR 155.88 0.00054005 58884000.0 12638.4 12761.7 18591.3 24525.0 14467.199999999999 15664.2 18281.3 26825.0 13773.6 14625.2 True False 11936.008323523767 13740.48135466694 17395.15599867694 21184.65269201524 12649.700997591019 17821.801364549985 19131.416673708733 26903.0563088822 16528.704866538887 14202.932475166908 0.8403904154577415 0.9674397437776642 1.2247580581750612 1.491568922759825 0.890640085750486 1.2547973030013684 1.3470046912606972 1.8941902565488358 1.1637529711162446 1.0 13.793901212842679 -4.1988166050920555 0.6102154772605247 1.3514488566576575 1.0592500953332042e-09 0.2359932192624603 0.26396534158070184 9.381894054287159 1.577804282072868 0.12819432354366891 10.419014744391982 6.326789641532354e-05 4.1988166050920555 -1.3514488555984074 S(ph)GELQGGPDDNLIEGGGTK ddPTM_A459_Selumetinib_30min_R1 1 SGELQGGPDDNLIEGGGTK 19 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 1 S(1)GELQGGPDDNLIEGGGTK 127.49 0.00079895 0.0 557.91 577.97 435.96 513.34 433.43 536.45 512.32 258.07 305.45 506.88 True False 570.9082174961164 510.3010037090365 376.75902655686457 423.69480558523867 394.2263330282816 531.0538000576288 473.6752899288014 251.22514527049907 518.3263408146706 571.942985429308 0.9981907848167508 0.8922235549859883 0.6587352868294455 0.740799024341924 0.6892755800342059 0.9285082841937693 0.8281862038630554 0.4392485818878015 0.9062552632332889 1.0 9.159727527795754 -5.029337875432517 4.699000703676966 0.757260213035397 0.9800941610715526 0.176729411704167 0.1522559776104537 0.2666377046625087 14.890271632082591 0.037820371364609244 0.12661088488153655 9.34678223765025e-06 5.029337875432517 0.22283394803615553 S(ph)GEQITSSPVSPK ddPTM_A459_Selumetinib_30min_R1 2 SGEQITSSPVSPK 13 0 A0A087WZV0;O43314;O43314-2;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 S(0.993)GEQIT(0.004)S(0.003)S(0.001)PVSPK;S(0.671)GEQIT(0.242)S(0.067)S(0.019)PVS(0.001)PK 145.94 0.00061379 15836000.0 5314.0 5084.8 5320.5 5986.7 5125.9 4991.9 4548.8 4656.3 2591.19 4239.1 True False 5437.805860755971 4489.4692521406105 4598.005323414528 4941.2352292771775 4662.26325005115 4941.686018282553 4205.68035374011 4532.799798206008 4397.060176970261 4783.229777330692 1.1368481369068932 0.9385853201988519 0.9612762793052503 1.033033213811999 0.9747102830282496 1.033127457456223 0.8792553461830792 0.9476441670622736 0.9192659315279779 1.0 12.223769381997823 -7.248587126288917 24.90942245544935 0.9321783726078573 1.0063794172468576 0.28745425777325584 0.058213212891189414 958.7253201204927 1858143.2117848496 0.021506481344199104 0.016550499759129457 5.641737478832845e-08 7.248587126288917 0.07420104463900035 S(ph)GEQITSSPVSPK ddPTM_A459_Selumetinib_30min_R2 2 SGEQITSSPVSPK 13 0 A0A087WZV0;O43314;O43314-2;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 S(0.961)GEQIT(0.028)S(0.008)S(0.003)PVSPK;S(1)GEQITSSPVSPK 150.39 0.00036477 24335000.0 118682.0 94330.0 122771.0 123645.0 123750.0 82438.0 107174.0 96241.0 78352.0 103791.0 True False 112086.12956168871 101564.80768124423 114872.04752295784 106804.33770047806 108203.41866096332 93793.08620234506 112157.80336125226 96521.0453764447 94024.58933779526 100794.28414859623 1.1120286284929157 1.0076445161464915 1.13966827080797 1.059626928279202 1.0735074868079242 0.9305397324323507 1.1127397184140257 0.9576043541729837 0.9328365207612296 1.0 16.62105430311309 -6.969549371533712 0.756453089577545 0.9704238358185833 1.0839788843658438 0.3358234555247862 0.06004163302350345 0.8078770886698627 0.9740133387788019 0.04482971594594836 0.035797937841846844 1.0726317018180057e-07 6.969549371533712 0.1135550485472605 S(ph)GFGEISSPVIR ddPTM_A459_Selumetinib_30min_R1 1 SGFGEISSPVIR 12 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 S(1)GFGEISSPVIR 89.663 0.02547 3371300.0 1337.7 1716.8 1308.3 1467.2 1481.6 1315.4 1399.2 1387.2 655.84 1081.3 True False 1368.8658072889089 1515.796257881334 1130.6400459774893 1210.98106275502 1347.5895415977254 1302.1682702876415 1293.6572174976166 1350.4069497393582 1112.9125793416065 1220.0953877539273 1.1219334332611919 1.2423588131676837 0.9266816818797124 0.992529825872315 1.1044952346541543 1.0672675951056598 1.0602918677359392 1.1068044050435444 0.9121521075416623 1.0 10.252778227581384 -5.251293480553728 24.99453974046487 1.0300734660697295 1.1821461260410508 0.4599845644554821 0.0691976795558246 636.159215149336 1567177.9372379351 0.017680563504838927 0.045651505660869694 5.606689681114822e-06 5.251293480553728 0.15207265997132136 S(ph)GGDGGDEVEGSGVGAGEGETVQHFPLAR ddPTM_A459_Selumetinib_30min_R2 2 SGGDGGDEVEGSGVGAGEGETVQHFPLAR 29 0 Q96DT7-3;Q96DT7-2;Q96DT7 Q96DT7-3 ZBTB10 Zinc finger and BTB domain-containing protein 10 1 S(1)GGDGGDEVEGSGVGAGEGETVQHFPLAR;S(1)GGDGGDEVEGSGVGAGEGETVQHFPLAR 222.78 8.756200000000003e-47 9912500.0 11843.4 11365.900000000001 11062.5 15600.6 14113.3 12607.7 12308.3 13589.5 11925.2 11776.5 True False 11185.191240886608 12237.627982871332 10350.750793939293 13475.77136746392 12340.261079497153 14344.296233694473 12880.66033843375 13629.043195137167 14310.573217927742 11436.481845978382 0.9780272807253099 1.0700517998176748 0.9050642438241718 1.1783144107558436 1.0790259841873122 1.254257771478789 1.126278213169482 1.1917164193225904 1.2513090485917249 1.0 13.48135569005948 -5.777171912327982 24.9995889599868 1.1622493609426883 0.9929481758253981 0.4766086995041394 0.0812155730796394 186.82216371541378 296867.0535350816 0.02166345301874228 0.03225373857990609 1.670429256089092e-06 5.777171912327982 -0.1693011851172902 S(ph)GGGAGSNGSVLDPAER ddPTM_A459_Selumetinib_30min_R1 2 SGGGAGSNGSVLDPAER 17 0 Q15149-3;Q15149-2;H0YDN1;E9PMV1 Q15149-3 PLEC Plectin 1 S(1)GGGAGSNGSVLDPAER;S(1)GGGAGSNGSVLDPAER 200.4 5.3235e-08 38853000.0 1861.47 1827.58 1857.37 1959.3 1976.3200000000002 1613.97 2108.05 1461.5 1055.83 1352.3200000000002 True False 1904.8386292099026 1613.6060839811082 1605.1493558031088 1617.1450356160797 1797.5622049476362 1597.7349271675098 1949.0380912992084 1422.7362723789452 1791.6663952278736 1525.9034447122822 1.248334968906942 1.0574758773713646 1.0519337651182568 1.0597951274177781 1.1780314220907844 1.047074723308441 1.2773010625627828 0.9323894492204978 1.1741676063688962 1.0 10.575447959651084 -14.522878542705795 0.28718657779522117 0.17026451365304435 1.1146796395550083 0.10194215777059645 0.10010613694124706 593.6598422042839 5.616027477724769 294.60789197566174 0.10289881802020809 3.0000013993356896e-15 14.522878542705795 0.944415125901964 S(ph)GGGAGSNGSVLDPAER ddPTM_A459_Selumetinib_30min_R2 3 SGGGAGSNGSVLDPAER 17 0 Q15149-3;Q15149-2;H0YDN1;E9PMV1 Q15149-3 PLEC Plectin 1 S(1)GGGAGSNGSVLDPAER;S(1)GGGAGSNGSVLDPAER;S(1)GGGAGSNGSVLDPAER 227.36 3.1848999999999997e-16 49495000.0 53709.6 56011.0 47499.6 68346.0 79644.0 55460.0 66344.0 55400.4 54075.1 60270.0 True False 50724.63544856409 60306.86359624892 44443.527449654175 59037.1568965738 69638.40869360622 63099.11158424581 69429.12745814193 55561.605991970064 64891.63098453397 58529.84849973397 0.8666455962002814 1.0303608354038885 0.7593309839142361 1.008667515974215 1.1897930795758467 1.0780672289717717 1.1862174469571283 0.9492866873254012 1.108692960051467 1.0 15.836884923910944 -5.994155422535756 24.698371700605048 1.0885547415560228 0.8972809194935624 0.4827222173384086 0.09231427074701268 112.95172154325975 477309.39917787473 0.025009261715505444 0.0369700010884875 1.0135485985247014e-06 5.994155422535756 -0.19127382206246046 S(ph)GGGDLTLGLEPSEEEAPR ddPTM_A459_Selumetinib_30min_R1 2 SGGGDLTLGLEPSEEEAPR 19 0 B4DTR1;P04626-3;P04626-2;P04626-5;P04626-4;P04626 B4DTR1 ERBB2 Receptor protein-tyrosine kinase;Receptor tyrosine-protein kinase erbB-2 1 S(1)GGGDLTLGLEPSEEEAPR;S(0.999)GGGDLT(0.001)LGLEPSEEEAPR 217.91 4.1895e-19 7678500.0 1997.83 1787.7399999999998 2178.0 1801.51 2586.8 1980.23 2241.2 2097.6800000000003 966.91 2111.17 True False 2044.3755518995285 1578.4305697022226 1882.239562897631 1486.91009703094 2352.824396736633 1960.3106841049832 2072.1444795995285 2042.042712175071 1640.7756496877182 2382.159234037233 0.8582027274619942 0.6626049791923992 0.7901401115439505 0.6241858544909091 0.987685610230646 0.8229133703974483 0.8698597683949539 0.8572234311617617 0.6887766469359675 1.0 11.218054137191457 -6.256638259595551 24.99942645675558 0.8614686515947207 0.732724728515411 0.30407484256024486 0.1011226309049276 540.0014954256287 2811785.2721160064 0.028908530369306497 0.03609727910473916 5.538112075903018e-07 6.256638259595551 -0.1287439230793097 S(ph)GGGDLTLGLEPSEEEAPR ddPTM_A459_Selumetinib_30min_R2 2 SGGGDLTLGLEPSEEEAPR 19 0 B4DTR1;P04626-3;P04626-2;P04626-5;P04626-4;P04626 B4DTR1 ERBB2 Receptor protein-tyrosine kinase;Receptor tyrosine-protein kinase erbB-2 1 S(1)GGGDLTLGLEPSEEEAPR;S(1)GGGDLTLGLEPSEEEAPR 235.72 8.9399e-25 3807000.0 12981.7 6337.9800000000005 11183.7 10678.2 6810.8 6453.6 15916.1 12214.4 8261.4 4613.1 True False 12260.22908386256 6824.082686182249 10464.152917891877 9223.810739077551 5955.1664146754665 7342.524820052085 16656.230187153844 12249.941881797222 9913.910842802492 4479.907816726773 2.736714589993606 1.5232640860829674 2.3357964819770487 2.058928691487427 1.3293055701817065 1.6389901579307211 3.7179850274963147 2.7344182922825397 2.212972062904199 1.0 12.12925333084688 S(ph)GGGSGGSGGQVSLK ddPTM_A459_Selumetinib_30min_R2 1 SGGGSGGSGGQVSLK 15 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 S(0.956)GGGS(0.044)GGSGGQVSLK 125.39 0.001446 0.0 10575.0 7660.8 8550.4 8634.5 10207.0 8004.8 8152.7 7468.9 8960.0 9925.4 True False 9987.283835079115 8248.358726645549 8000.276572971625 7458.466204656692 8924.705408262245 9107.388539660482 8531.81670426858 7490.633262457042 10752.2503633174 9638.82791271378 1.03615127539581 0.8557429182614437 0.8300051256666926 0.7737938961249476 0.9259118939648674 0.9448647306637439 0.8851508483738949 0.7771311336077251 1.1155142991125506 1.0 13.234642009195923 -8.269616424839914 24.999055558921384 1.0577571615803776 0.8767241619142427 0.4515015941742554 0.07896750499289762 610.1809307458439 1865435.568252975 0.07199137556162542 0.019867894979042917 5.375063201328588e-09 8.269616424839914 -0.18103299966613484 S(ph)GGNEVSIEER ddPTM_A459_Selumetinib_30min_R2 2 SGGNEVSIEER 11 0 Q15061 Q15061 WDR43 WD repeat-containing protein 43 1 S(0.996)GGNEVS(0.004)IEER;S(0.999)GGNEVS(0.001)IEER 129.76 0.0025233 58591000.0 7866.700000000001 5830.0 25400.7 22049.9 22680.3 18019.0 20781.6 17206.4 20987.1 19822.2 True False 7429.50030689521 6277.142253595389 23766.44661619108 19046.665581800873 19830.997949545428 20500.953689803915 21747.985577959193 17256.467775327143 25185.10642856902 19249.88158173927 0.38595044210261253 0.32608731783316425 1.234628198374804 0.9894432597377029 1.030188048967398 1.06499115865998 1.1297724344751119 0.8964453990042666 1.3083252653595538 1.0 14.23256195044982 -5.255044016240996 24.999839727691928 1.0740079178410709 0.3560187835323734 0.8647088420049414 0.11478820531947763 151.76312195533927 593246.6520251889 0.027267821035344492 0.06856422805585465 5.558479185950371e-06 5.255044016240996 -0.7179891343086975 S(ph)GGSIDNVLSQIAAQR ddPTM_A459_Selumetinib_30min_R2 1 SGGSIDNVLSQIAAQR 16 0 H7C163;A0A0A0MRS7;Q68DC2;Q68DC2-4 H7C163 ANKS6 Ankyrin repeat and SAM domain-containing protein 6 1 S(0.997)GGS(0.003)IDNVLSQIAAQR 117.27 0.0018546 1470600.0 3914.1 2668.8 4685.6 3412.8 4223.6 2653.0 2767.7 3659.9 2525.4 3211.3 True False 3696.569991383748 2873.488378455467 4384.133597295544 2947.9707525916224 3692.9936085369245 3018.426668463831 2896.4035340935075 3670.549703070939 3030.550565571624 3118.5814250405774 1.185337013073388 0.9214088031766169 1.4058102065552127 0.9452922180966511 1.18419021510361 0.9678845144870818 0.9287567452422124 1.176993383465426 0.9717721465400544 1.0 11.60667421232048 -6.766276889510911 24.999584757442378 1.0151231555778497 1.1221459228290367 0.15108706372554015 0.14067029537767806 266.2431095186944 1375897.1073012683 0.0466338050487504 0.042410767221806964 1.7128649023167258e-07 6.766276889510911 0.10702276725118698 S(ph)GHFDVTTVASIK ddPTM_A459_Selumetinib_30min_R1 2 SGHFDVTTVASIK 13 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0A0MSL1;Q8TDM6-5 Q8TDM6-4 DLG5 Disks large homolog 5 1 S(1)GHFDVTTVASIK;S(0.999)GHFDVT(0.001)TVASIK 170.79 0.00021865 20123700.0 2793.8999999999996 2394.8 2641.4 2861.9 2576.7 2040.3400000000001 2289.9 2265.46 1293.0700000000002 2029.29 True False 2858.9924340169555 2114.4157026876846 2282.712388171626 2362.122889516488 2343.6379399533344 2019.8160320804975 2117.1709993909326 2205.3726415488227 2194.2453479038354 2289.7691384584905 1.2485941861989087 0.923418726881411 0.9969181389650421 1.0315987100370771 1.0235258658133148 0.8821046620622506 0.9246220345236403 0.9631419187671972 0.9582823486655239 1.0 11.160986433381376 -4.756069796104971 24.99974574836756 0.9666483853223141 1.2485946290954804 0.7780557112035865 0.045107809355872 84.63281936162642 393991.8682736933 0.012172618246363523 0.1018952768315425 1.753598655775159e-05 4.756069796104971 0.28194624377316624 S(ph)GIDITDFQAK ddPTM_A459_Selumetinib_30min_R2 2 SGIDITDFQAK 11 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 S(1)GIDITDFQAK;S(1)GIDITDFQAK 91.202 0.02675 5878000.0 52199.0 42668.0 48905.0 53066.0 50201.0 52358.0 49349.0 54585.0 41554.0 48261.0 True False 49297.988549153175 45940.49840075611 45758.505543738 45838.31925604404 43894.30157736582 59569.83924139813 51643.82628318839 54743.8333129668 49865.96111576911 46867.57953286311 1.0518569348047062 0.9802191378059766 0.9763360088107935 0.9780389709245095 0.9365600275257985 1.2710244445124015 1.1019093966006124 1.1680533507086908 1.0639756013174004 1.0 15.516302668582192 -6.735173055762175 24.999998900529576 1.1303033035957137 0.9835348291187558 0.4776399522140161 0.07097864168928342 176.56016975382082 168047.6889245899 0.022278926818797 0.022272339957115844 1.840038644829704e-07 6.735173055762175 -0.14676847447695796 S(ph)GITSPVEK ddPTM_A459_Selumetinib_30min_R2 1 SGITSPVEK 9 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 S(0.61)GIT(0.225)S(0.165)PVEK 98.943 0.019249 15648000.0 151510.0 120550.0 151910.0 172570.0 151050.0 130780.0 148880.0 162690.0 107160.0 150800.0 True False 143089.6807425849 129795.79737065588 142136.27598710204 149065.6683001456 132073.74859586687 148793.75789736147 155803.21500012322 163163.40096522067 128594.99430056807 146446.01217454587 0.9770814419448948 0.8863047579332857 0.9705711605017475 1.0178882038964463 0.9018596453036289 1.0160314759545475 1.0638952381606999 1.114153936610781 0.8781051282386471 1.0 17.16000938261252 -6.896659273209427 8.224967766547675 1.0258293040168633 0.9521403503091038 0.17905481918724742 0.06625223708880494 0.38602647976835264 27.620804799382366 0.02304352374706213 0.020326235237389096 1.2686467954442004e-07 6.896659273209427 -0.07368895370775952 S(ph)GKDSEAWVPDSEER ddPTM_A459_Selumetinib_30min_R2 2 SGKDSEAWVPDSEER 15 1 Q96F63;M0QXS4 Q96F63 CCDC97 Coiled-coil domain-containing protein 97 1 S(0.992)GKDS(0.008)EAWVPDSEER;S(0.986)GKDS(0.014)EAWVPDSEER 92.671 0.007294499999999998 26091000.0 66805.0 44921.0 58189.0 70534.0 65580.0 52264.0 79821.0 74876.0 60027.0 51021.0 True False 63092.245541603865 48366.29625621926 54445.18309139288 60927.147522063235 57341.25410736134 59462.891594645145 83532.83466231095 75093.87676361084 72034.07729451478 49547.8911615219 1.273358846614249 0.9761524682967689 1.0988395634015224 1.2296617695281105 1.1572894983650008 1.200109433533734 1.6859009072656803 1.5155816928476573 1.4538273094144376 1.0 15.596536034830871 -7.082243626942375 7.862265334025732 1.4565106942846247 1.1432293285682493 0.3263923382708446 0.17862114843043525 0.2979676847053572 25.673176730445032 0.06530989510616485 0.050629092412512455 8.274778417827277e-08 7.082243626942375 -0.3132813657163753 S(ph)GLCSPSYVAVTPFSLR ddPTM_A459_Selumetinib_30min_R1 1 SGLCSPSYVAVTPFSLR 17 0 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 S(0.595)GLCS(0.203)PS(0.203)YVAVTPFSLR 182.7 6.8503e-08 31532000.0 1786.0 1634.9 2413.5 2628.7 2171.3 2139.9 1633.5 1798.6 1033.7 1326.5 True False 1827.610325048958 1443.4851479556096 2085.759956406534 2169.646891810332 1974.9062983741494 2118.3745488737436 1510.283779861605 1750.8952853238256 1754.1134015391228 1496.7691962041847 1.2210368369978406 0.9644006247698684 1.393508071716089 1.4495534096456346 1.3194461132568223 1.4152980661587329 1.0090291700896126 1.169783083299754 1.171933125018583 1.0 10.547636057719565 -7.267143303121431 24.94890524794172 1.1018349373819636 1.2916653449110125 0.3452058330316269 0.13855034543777772 655.2784944466381 2866168.822306896 0.062092125568745486 0.0431456468664734 5.40575920957644e-08 7.267143303121431 0.1898304075290489 S(ph)GLSDIILGK ddPTM_A459_Selumetinib_30min_R2 1 SGLSDIILGK 10 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;K7EJR2;M0R330;M0QX30;M0R1V5 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 S(0.944)GLS(0.056)DIILGK 85.963 0.043044 0.0 38343.0 26205.0 38012.0 43013.0 40687.0 26228.0 27595.0 34325.0 24438.0 36858.0 True False 36212.049559190375 28214.83923764445 35566.34930433633 37154.555198436334 35575.535313604974 29840.66892592135 28878.222178455148 34424.880067190345 29326.282854771256 35793.81377141521 1.0116845829965502 0.7882602121648379 0.993645145819568 1.0380161062386652 0.9939017826039942 0.8336822981895263 0.8067936644828044 0.961755019653198 0.8193114889084857 1.0 15.12742264825421 -6.757105930626623 24.999383947480272 0.8770735051019127 0.960913610304288 0.17963086024389407 0.08540003199378124 198.23440040057744 1143600.5342118186 0.02905010662162765 0.028086514525451137 1.7494199280750343e-07 6.757105930626623 0.08384010520237528 S(ph)GMSPEQSR ddPTM_A459_Selumetinib_30min_R1 1 SGMSPEQSR 9 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.752)GMS(0.219)PEQS(0.029)R 91.469 0.027177 60371000.0 3973.7 4653.3 4784.7 5240.4 5101.7 3818.2 4287.7 4326.2 2238.1 3573.8 True False 4066.2794785257793 4108.48947273952 4134.964020475801 4325.262514491142 4640.2521357782925 3779.792374648222 3964.2753369529255 4211.455122521923 3797.892235643524 4032.532041759905 1.008368795688762 1.0188361630342968 1.025401404788638 1.0725922248601605 1.1507043435055166 0.9373248211063487 0.9830734873027344 1.0443699092553103 0.941813281658643 1.0 11.977470281478706 -6.795409503670091 24.999999203029958 0.9841992739277465 1.052474634593702 0.3842849542734412 0.04661426636404439 230.49910019809232 169632.1330873107 0.01726155848346521 0.015224035134384523 1.6017343757746073e-07 6.795409503670091 0.06827536066595541 S(ph)GNWESSEGWGAQPEGAGAQR ddPTM_A459_Selumetinib_30min_R2 1 SGNWESSEGWGAQPEGAGAQR 21 0 Q9Y5X1 Q9Y5X1 SNX9 Sorting nexin-9 1 S(0.711)GNWES(0.23)S(0.059)EGWGAQPEGAGAQR 164.18 8.4657e-09 0.0 1164.7 1087.1 3841.2 3445.2 1875.0 1975.7 1281.4 0.0 1375.0 3308.6 True False 1099.9706366635126 1170.4770744225643 3594.061373982341 2975.957816698506 1639.4457372873221 2247.834741381073 1340.9876390459292 0.0 1650.0384207099785 3213.0721212248163 0.34234234251928525 0.36428596379479367 1.1185747591038486 0.9262032423860057 0.5102424332331417 0.6995905029745186 0.41735373139858045 0.0 0.5135391794694566 1.0 11.649737648840732 -7.278315699491745 8.841656907689577 0.39901941974794203 0.6729100608492147 0.04337142753850687 0.3206715193393283 0.5639140482572602 265.89435781703304 0.13525365567996528 0.09374567566213465 5.268467441511875e-08 7.278315699491745 0.27389064110127265 S(ph)GPIFR ddPTM_A459_Selumetinib_30min_R2 1 SGPIFR 6 0 A0A087WYN8 A0A087WYN8 1 S(1)GPIFR 99.375 0.033329000000000004 2521300.0 5449.9 4619.5 5077.2 6296.2 6102.5 5595.2 5211.4 5014.9 4841.5 5221.0 True False 5147.016375678264 4973.800795966362 4750.538479637389 5438.646698449188 5335.849392957809 6365.8880118314455 5453.740426193195 5029.49252873861 5809.93528281263 5070.256164212892 1.0151393162355709 0.9809762337202337 0.9369424987178856 1.0726571838394452 1.0523826055613401 1.2555357768239481 1.0756341000454825 0.9919602414248808 1.1458859463197488 1.0 12.307842922917061 -5.8734259574957814 5.58952571496185 1.091569422344075 0.9785507043250563 0.31180436119047383 0.07287614663959047 0.24996504540579603 11.2779974798956 0.021172510606035116 0.031929681036434836 1.3383633721600603e-06 5.8734259574957814 -0.11301871801901875 S(ph)GPLEESER ddPTM_A459_Selumetinib_30min_R2 2 SGPLEESER 9 0 A0A2R8Y4Z8;Q9Y3X0 A0A2R8Y4Z8;Q9Y3X0 CCDC9 Coiled-coil domain-containing protein 9 1 S(1)GPLEESER;S(1)GPLEESER 90.827 0.030223000000000007 10321000.0 18349.8 10985.5 21595.7 23241.1 24265.4 21109.7 21199.7 12072.0 14299.6 20343.6 True False 17329.991576069482 11828.052526050114 20206.256173620324 20075.62208686625 21216.96351657164 24017.36956022274 22185.528056408613 12107.12752137281 17159.91956420685 19756.227408979375 0.8771913390809043 0.5986999583065218 1.022779084049033 1.016166784845861 1.0739380083734178 1.2156860246155416 1.122963792486267 0.6128258837448902 0.8685828123444014 1.0 14.270019859974848 -5.278072417062522 24.148737490129147 0.9943002903772068 0.7379456448193209 0.2735017242559835 0.16532880620631477 641.2527921496655 931005.4305366104 0.04744092083152831 0.09924255098780542 5.271419550450544e-06 5.278072417062522 -0.2563546455578859 S(ph)GRESVSTASDQPSHSLER ddPTM_A459_Selumetinib_30min_R1 1 SGRESVSTASDQPSHSLER 19 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.945)GRES(0.022)VS(0.026)T(0.006)AS(0.001)DQPSHSLER 103.71 0.00053634 4180400.0 664.51 750.78 599.16 792.08 593.11 770.53 792.7 641.99 388.78 572.43 True False 679.9917900886246 662.8783285718473 517.7973629502959 653.7580971830674 539.4633052220754 762.7791677852636 732.9060007935686 624.9623397225853 659.7312646322725 645.9069664403777 1.0527704846351014 1.0262752424315835 0.8016593563062192 1.0121552036912649 0.8352027973859485 1.180942778785889 1.1346928255514048 0.9675733072934339 1.0214029247402008 1.0 9.335182570296407 -6.759416530145712 24.999999931295314 1.0635063414022752 0.9457932970688866 0.27128934980734654 0.09444469669017641 77.46432407506839 957371.8164190251 0.03288296691322278 0.03132660281756597 1.7401371140627323e-07 6.759416530145712 -0.11771304433338858 S(ph)GS(ph)LQIKNRNHMK ddPTM_A459_Selumetinib_30min_R2 2 SGSLQIKNRNHMK 13 2 A6NHS7 A6NHS7 MANSC4 MANSC domain-containing protein 4 2 S(1)GS(1)LQIKNRNHMK;S(1)GS(1)LQIKNRNHMK 95.094 0.028864 22458000.0 14561.0 11381.2 39454.0 45265.0 59427.0 36229.0 14226.9 29135.0 46270.0 38577.0 True False 13751.757912301362 12254.101443674075 36915.57259426723 39099.82891351966 51961.248975879345 41219.21589588243 14888.47904006753 29219.778026441094 55525.292891818724 37463.181774916826 0.3670739446244457 0.3270971888425855 0.985382737004569 1.0436868162569855 1.3869950846158396 1.1002593464573376 0.3974162987415018 0.7799598603769679 1.4821296606738097 1.0 15.193185813459243 -5.2686587595544605 8.116695340946372 1.0088727827939095 0.3458361717434097 0.474952188236756 0.2835792856876649 0.1135442172463924 74.15792582618847 0.07917416189400149 0.17998933044954224 5.3869288621356395e-06 5.2686587595544605 -0.6630366110504997 S(ph)GSESEEAELSLSLAR ddPTM_A459_Selumetinib_30min_R1 1 SGSESEEAELSLSLAR 16 0 Q8IV50 Q8IV50 LYSMD2 LysM and putative peptidoglycan-binding domain-containing protein 2 1 S(0.989)GS(0.011)ESEEAELSLSLAR 199.33 8.336200000000002e-07 7160800.0 1223.2 1680.4 1531.1 1662.9 1536.1 1480.6 1443.8 1470.0 739.76 1106.4 True False 1251.698180067126 1483.6579868032334 1323.1850297302854 1372.5057314989924 1397.160026220482 1465.7065082772388 1334.8930035899518 1431.010824767054 1255.3186900673134 1248.417217248631 1.0026280980213698 1.1884312121816505 1.0598900843793504 1.0993966700682312 1.1191451118398248 1.1740518217999978 1.0692683384581188 1.1462600843657367 1.0055281781790004 1.0 10.285884443754 -8.275621784455405 23.736846129414342 1.0027640096847164 1.1095799150818946 0.3888556241454938 0.05240501462733244 434.1122921365224 726552.2193839045 0.04560191303404051 0.0120429111355424 5.301249146477345e-09 8.275621784455405 0.10681590539717822 S(ph)GSESEEAELSLSLAR ddPTM_A459_Selumetinib_30min_R2 2 SGSESEEAELSLSLAR 16 0 Q8IV50 Q8IV50 LYSMD2 LysM and putative peptidoglycan-binding domain-containing protein 2 1 S(0.732)GS(0.268)ES(0.001)EEAELSLSLAR;S(0.967)GS(0.033)ESEEAELSLSLAR 107.5 0.004774100000000001 0.0 15237.900000000001 14931.599999999999 17536.4 17691.300000000003 18469.1 13656.2 14953.3 12754.400000000001 15861.4 16937.9 True False 14391.03852014677 16076.805707338754 16408.127116188676 15281.714420805256 16148.846542151095 15537.217591359127 15648.658079401826 12791.51319239542 19034.123204544918 16448.858817050674 0.8748958623943691 0.9773812205545679 0.9975237369768305 0.9290440504580433 0.9817609064412062 0.9445772356714163 0.951352203423415 0.7776535341853565 1.1571698326460431 1.0 14.00569987620958 -8.283482441043382 24.98943871152613 1.078584898201461 0.9361401713475775 0.4180837905450915 0.0700878358677104 896.0972772553607 1015863.7402550173 0.06470861786497148 0.016763830768967727 5.206160573995625e-09 8.283482441043382 -0.14244472685388343 S(ph)GSGGGSAKEPQEER ddPTM_A459_Selumetinib_30min_R2 1 SGSGGGSAKEPQEER 15 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 S(0.499)GS(0.499)GGGS(0.001)AKEPQEER 148.36 0.0014532 7417600.0 7681.4 9920.2 9664.4 10058.0 8763.2 5639.0 5899.5 3674.0 4886.1 6499.1 True False 7254.498539080541 10681.047441529505 9042.60302580312 8688.083048982227 7662.288471998007 6415.721064254633 6173.8384396374795 3684.6907317365594 5863.456529040749 6311.45409631029 1.1494179357688048 1.6923275173265862 1.4327289540281176 1.376558066715771 1.2140290264453355 1.016520276683197 0.9781958872594413 0.5838101134080417 0.9290183275623533 1.0 12.62375671076676 -6.721141883307605 1.2847544351872018 0.8278996565895208 1.4496024391742182 0.6934823952952973 0.16302783843388505 0.22373702322246122 0.7762927010141342 0.07550923809971463 0.07067205277579106 1.900457302153559e-07 6.721141883307605 0.6217027825846974 S(ph)GSISVK ddPTM_A459_Selumetinib_30min_R2 1 SGSISVK 7 0 Q8TF01 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 S(0.73)GS(0.267)IS(0.003)VK 88.37 0.032367 24271000.0 185220.0 135340.0 123060.0 175460.0 166140.0 139110.0 124630.0 167930.0 99583.0 191300.0 True False 174926.2138944071 145720.14281331078 115142.45357759712 151562.0453146171 145268.00788955519 158271.13978515004 130425.5419496599 168418.64849769202 119502.3825814993 185776.6719429089 0.9415940767211275 0.7843834281738673 0.6197896236023734 0.8158292627892144 0.7819496730687346 0.851943024546098 0.7020555411270422 0.9065651071058525 0.6432582806641278 1.0 17.50320982768997 -11.295101614426528 2.7094354890486736 1.0524877856624157 0.7824888149480461 0.2997214749823053 0.09948590179894606 118578416.24990197 88560865.06456755 41287831.82628853 0.023918252673396187 5.068720985622651e-12 11.295101614426528 -0.2699989707143696 S(ph)GSLGQPSPSAQR ddPTM_A459_Selumetinib_30min_R2 2 SGSLGQPSPSAQR 13 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 S(0.965)GS(0.002)LGQPSPS(0.033)AQR;S(0.594)GS(0.196)LGQPS(0.014)PS(0.196)AQR 141.89 0.0008048 17924700.0 25307.0 22329.0 21994.7 22456.0 20793.1 13975.2 19815.6 20385.0 15576.300000000001 20733.5 True False 23900.53825194771 24041.5625009488 20579.584948018684 19397.454061239314 18180.884885327494 15900.15694576545 20737.064663866495 20444.316975081587 18691.995238185355 20134.869982897533 1.1870222292097599 1.194026210319192 1.0220868058993622 0.9633761766386086 0.9029551668707201 0.7896826231940395 1.0299080491446164 1.0153687107215938 0.9283395052494627 1.0 14.297408535933709 -5.400730589503955 2.333868734389527 0.9424394152128244 1.199974851850467 0.6858576482223522 0.06494418052663968 0.1842232695880611 1.9157061689078594 0.019746944827171313 0.05506306862436668 3.9743801995032895e-06 5.400730589503955 0.25753543663764256 S(ph)GSLLQVEETEREEGLGAGR ddPTM_A459_Selumetinib_30min_R1 1 SGSLLQVEETEREEGLGAGR 20 1 Q8WYL5-4;Q8WYL5;Q8WYL5-2;Q8WYL5-5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 S(0.784)GS(0.216)LLQVEETEREEGLGAGR 66.711 0.0084447 1788800.0 432.61 597.74 551.85 591.67 516.73 579.9 511.23 369.62 256.11 435.59 True False 442.68897128747494 527.756322918213 476.9118010950676 488.34594152144376 469.99186273609143 574.0667325070722 472.66750950636566 359.816476905033 434.5999644656913 491.50221950590344 0.9006855996143834 1.0737618305137158 0.9703146438982446 0.9935783036999658 0.9562354839588804 1.1679840084632152 0.9616792981759636 0.7320749787595033 0.8842278777552323 1.0 8.94105412121938 -7.53582309003967 24.800742498438773 0.8542662131562271 1.012968051726994 0.3104314053120857 0.09100207412199422 214.5175275110836 410999.47341838 0.04078511270013525 0.02356639143116646 2.911903040902401e-08 7.53582309003967 0.1587018385707668 S(ph)GSMDPSGAHPSVR ddPTM_A459_Selumetinib_30min_R2 1 SGSMDPSGAHPSVR 14 0 Q07666-3;Q07666-2;Q07666 Q07666-3 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 S(0.759)GS(0.241)MDPSGAHPSVR 84.895 0.016729 16337000.0 34163.0 32820.0 74357.0 101420.0 126390.0 74688.0 40987.0 58968.0 76529.0 103570.0 True False 32264.357225324617 35337.18846706701 69572.95157378039 87606.42104074162 110511.75825906388 84975.59404984032 42892.976714199736 59139.587117322066 91836.93839891924 100579.66499282328 0.3207840991280573 0.3513353168315727 0.6917198578733054 0.8710152399791017 1.0987485220491566 0.8448585910074728 0.42645774090876426 0.5879875133958926 0.9130765985895075 1.0 16.617979127696735 -5.320036575110278 3.2104499975853016 0.7986176489195268 0.32128473333269786 0.5189069149658805 0.18302880901968058 0.22289468352487848 4.523859374746129 0.05496615746675104 0.14254811611094104 4.785897850841006e-06 5.320036575110278 -0.47733291558682894 S(ph)GSNGGGQAPGASPSVSLPASLGR ddPTM_A459_Selumetinib_30min_R2 1 SGSNGGGQAPGASPSVSLPASLGR 24 0 P38432 P38432 COIL Coilin 1 S(0.599)GS(0.401)NGGGQAPGASPSVSLPASLGR 270.05 2.6785999999999994e-73 5153500.0 10992.0 11335.0 18253.0 12287.0 15209.0 7868.9 12587.0 13701.0 11301.0 12204.0 True False 10381.10864446237 12204.358052230484 17078.62185236375 10613.48940374276 13298.309449814882 8952.769548237855 13172.320440667325 13740.867641677345 13561.515776322523 11851.638810199986 0.8759217869116954 1.0297612210158593 1.4410346219516257 0.8955292659280483 1.1220650293839394 0.755403509304785 1.1114345156494905 1.1594065480506726 1.1442734623882522 1.0 13.532798944147789 -10.5806713786667 3.7141823990156717 0.9999815934381866 1.0623271916908592 0.009503031102680026 0.17982498753739964 39765643.42203049 57567015.89571505 9054.958008347048 0.04496826792216616 2.6262049848081688e-11 10.5806713786667 0.06234559825267261 S(ph)GSPAPETTNESVPFAQHSSLDSR ddPTM_A459_Selumetinib_30min_R1 2 SGSPAPETTNESVPFAQHSSLDSR 24 0 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 1 S(0.5)GS(0.5)PAPETTNESVPFAQHSSLDSR;S(0.497)GS(0.497)PAPET(0.005)T(0.001)NESVPFAQHSSLDSR 198.85 6.5028e-31 26221000.0 4041.5 4479.6 4029.7000000000003 4927.9 6777.2 4225.4 6295.0 3952.7 1434.28 2819.2 True False 4135.659086609946 3955.126349490458 3482.488873557659 4067.334773139627 6164.203456611838 4182.896312356236 5820.163081866422 3847.8615558209076 2433.868404333494 3181.071781333461 1.3000835475885852 1.2433313742554166 1.0947533136450787 1.2786051534601515 1.9377756556087176 1.3149330162561828 1.8296233099860106 1.2096116718900125 0.7651095516345909 1.0 11.63529721152392 -8.005316417252846 24.810528614609296 0.9174899244113888 1.4252124914771076 0.42022254574683715 0.2545374891389107 206.91097082797424 965600.827639834 0.15294708199929932 0.07000909782992337 9.878331192775921e-09 8.005316417252846 0.5077225670657188 S(ph)GSPAPETTNESVPFAQHSSLDSR ddPTM_A459_Selumetinib_30min_R2 2 SGSPAPETTNESVPFAQHSSLDSR 24 0 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 1 S(0.5)GS(0.5)PAPETTNESVPFAQHSSLDSR;S(0.5)GS(0.5)PAPETTNESVPFAQHSSLDSR 184.6 3.1860000000000004e-21 32382000.0 63462.0 55968.0 106462.0 171453.0 218113.0 104669.0 74853.0 94338.0 101193.0 160824.0 True False 59935.036098514494 60260.565634515755 99612.35082706125 148100.80562707776 190711.69498504014 119086.2046594199 78333.81281840558 94612.50796150338 121434.42756865811 156180.5932490661 0.3837546960968077 0.3858390109865721 0.6378023591459043 0.9482663789789604 1.2210972632233905 0.7624904105051605 0.5015591962407531 0.6057891444337251 0.7775257158551243 1.0 17.252855672073203 -5.428878652672071 3.3867414506706837 0.813723875596125 0.3853343692506248 0.46037155172669597 0.19140396230747697 0.25498339850579804 5.45402208933383 0.05939067190621495 0.13541353470836082 3.7249577170812234e-06 5.428878652672071 -0.4283895063455002 S(ph)GSPRPTEPTDFLMLFEGS(ph)PSGK ddPTM_A459_Selumetinib_30min_R1 1 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 2 S(0.56)GS(0.176)PRPT(0.252)EPT(0.017)DFLMLFEGS(0.92)PS(0.074)GK 62.034 0.015457 16953000.0 2267.9 2581.4 3029.3 3489.6 2413.4 2043.9 2629.0 2172.5 1323.8 2096.7 True False 2320.737657434789 2279.1684879396994 2617.93769875381 2880.2068679047975 2195.108396120377 2023.3402217127166 2430.692413379957 2114.8782427254578 2246.3919134734374 2365.831868587497 0.9809393846826355 0.9633687491497275 1.1065611777039892 1.217418239286972 0.9278378676296009 0.8552341561451438 1.0274155343216274 0.893925840972009 0.9495146055389936 1.0 11.208131834682197 S(ph)GSPRPTEPTDFLMLFEGSPSGK ddPTM_A459_Selumetinib_30min_R1 1 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.468)GS(0.407)PRPT(0.105)EPT(0.02)DFLMLFEGSPSGK 100.06 9.2701e-05 49072000.0 7050.8 6634.2 8080.8 8940.2 7306.7 7058.8 7031.7 6493.0 3360.1 5259.9 True False 7215.069921531462 5857.464779844093 6983.471744657107 7378.961898338622 6645.810275102663 6987.794880877602 6501.293207745851 6320.784547763589 5701.84428800581 5935.059400764714 1.2156693698131853 0.9869260582445689 1.1766473211299802 1.2432835798387907 1.1197546353531644 1.1773757276931796 1.095404909832609 1.0649909497029086 0.9607055132878948 1.0 12.535046753747437 -7.875642036363819 1.7834770647727138 0.9813226929025184 1.1486906498698823 0.5019560893306674 0.06673869751639565 0.3220660088214144 1.9141364917714632 0.054389614539631814 0.019773411239925254 1.3315514860951372e-08 7.875642036363819 0.16736795696736395 S(ph)GSPVATFK ddPTM_A459_Selumetinib_30min_R2 1 SGSPVATFK 9 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 1 S(0.777)GS(0.223)PVATFK 98.04 0.020054 14084000.0 134450.0 127790.0 133890.0 162900.0 151920.0 110120.0 136940.0 125530.0 78884.0 145600.0 True False 126977.80724599388 137591.08209038692 125275.6631684098 140712.7389818258 132834.45141796803 125288.03043016836 143307.9813414621 125895.27151738979 94663.00420311699 141396.14968576815 0.8980287477995909 0.9730893125177918 0.8859906259598742 0.9951666950941653 0.939448858495601 0.8860780912959958 1.0135211012459866 0.890372699661011 0.6694878496585048 1.0 17.10938330954255 -8.006454658892084 24.99225376344977 0.8164727025730557 0.9413442092663553 0.1971607560068741 0.08508766991823391 337.9700230442659 1308603.2623882543 0.04463059778430876 0.02022251892354976 9.85247499006889e-09 8.006454658892084 0.1248715066932996 S(ph)GSS(ph)SPDSEITELKFPSINHD ddPTM_A459_Selumetinib_30min_R1 1 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 2 S(0.496)GS(0.496)S(0.337)S(0.336)PDS(0.333)EIT(0.002)ELKFPSINHD 80.238 0.0039951 3733200.0 305.07 511.89 339.2 189.11 486.53 406.5 569.79 391.51 157.77 389.94 True False 312.17753743711404 451.95768082879493 293.1385030922298 156.0854885343524 442.5234474038479 402.4109790724689 526.8102815594389 381.12588299629203 267.7241669351141 439.9925973372482 0.709506340166524 1.0271938290870282 0.666235079558721 0.3547457149937345 1.0057520287430197 0.9145857941878656 1.19731623838127 0.8662097619432546 0.6084742528745484 1.0 8.7813354410822 S(ph)GSS(ph)SPDSEITELKFPSINHD ddPTM_A459_Selumetinib_30min_R2 1 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 2 S(0.545)GS(0.46)S(0.48)S(0.48)PDS(0.03)EIT(0.004)ELKFPSINHD 59.342 0.044942 3800100.0 3732.7 3258.8 4190.4 5850.7 4957.2 4789.9 4151.9 4585.3 5895.8 3894.0 True False 3525.2514771820142 3508.739481306457 3920.7942261625512 5053.8245669795515 4334.4322180697145 5449.665246617001 4344.971576833775 4598.6424638627195 7075.1247424159255 3781.570102172956 0.9322189942099297 0.9278525550247698 1.0368164863344975 1.3364355097041665 1.1461990921652025 1.441111786737876 1.1489861246621023 1.2160669615037043 1.8709489844840999 1.0 11.884769648289428 -5.646132808251739 3.11497052546729 1.311500915149246 0.9345565617846336 0.33888634361167325 0.22189377532087134 0.27928331675411916 5.3642857692723265 0.061123563812824196 0.11593360762977184 2.2587449351990567e-06 5.646132808251739 -0.3769443533646124 S(ph)GSSPGLR ddPTM_A459_Selumetinib_30min_R2 2 SGSSPGLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.812)GS(0.122)S(0.066)PGLR;S(0.781)GS(0.209)S(0.01)PGLR 112.41 0.011184 264002000.0 104245.0 92233.0 84916.0 123350.0 111263.0 77186.0 130978.0 177499.0 124136.0 159468.0 True False 98451.48022579882 99306.97452416208 79452.59700955037 106549.51720938111 97285.14723615958 87817.67087525419 137068.73652798348 178015.4927034586 148966.66864963956 154863.74449237736 0.6357296896604793 0.6412538638380278 0.5130484043891962 0.6880210572115261 0.6281983401282675 0.5670641063414085 0.8850924855089645 1.1494975359595598 0.9619208752696273 1.0 17.240639905437945 -7.432668841177091 3.667614016595748 1.0406444199296896 0.6139927198951609 0.9006848862115808 0.06424178202342298 0.06534832682906128 1.6331681108475882 0.02856160020135119 0.017925018133724123 3.692590591699817e-08 7.432668841177091 -0.4266517000345287 S(ph)GSSQELDVKPSASPQER ddPTM_A459_Selumetinib_30min_R2 1 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.333)GS(0.333)S(0.333)QELDVKPSASPQER 56.684 0.03464 9940100.0 20143.0 21110.0 26103.0 22885.0 19337.0 12526.0 12828.0 15009.0 16531.0 20359.0 True False 19023.53269881782 22729.06912065157 24423.561398797527 19768.023521173018 16907.713185026656 14251.342800293236 13424.52741819978 15052.673705126297 19837.661914732118 19771.182770965388 0.962184858599076 1.1496059382967179 1.2353110930047293 0.9998402093678983 0.855169535423858 0.7208138716527261 0.678994654680656 0.7613441178254459 1.0033624262411027 1.0 14.271111559507059 -6.156702613700889 2.952538582579078 0.8083421394572751 1.1186957686010157 0.5179167772027401 0.11985862573519461 0.19696010370308076 3.3116613524795517 0.038236432025914584 0.05127262604438731 6.971036975320125e-07 6.156702613700889 0.31035362914374065 S(ph)GSSS(ph)PDSEITELK ddPTM_A459_Selumetinib_30min_R2 2 SGSSSPDSEITELK 14 0 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 2 S(0.982)GS(0.015)S(0.058)S(0.945)PDSEITELK;S(0.999)GS(0.061)S(0.244)S(0.695)PDS(0.001)EITELK 177.93 0.0012911 4131500.0 30767.0 22506.6 27959.4 29709.0 33267.9 35129.0 45604.0 44657.0 37897.0 24516.7 True False 29057.09331005947 24232.78384987479 26160.522643893008 25662.582949116422 29088.4889832005 39967.70088068825 47724.67636261165 44786.944476635676 45477.45893065169 23808.83916896346 1.2204330124560414 1.017806188613512 1.098773546170833 1.0778594776081922 1.2217516686457963 1.6786917076070234 2.0044940462626255 1.881105759033338 1.9101082000644045 1.0 14.53920966139223 -6.746487646050031 3.319346230855611 1.7815405833765627 1.102304667915751 0.52599047463317 0.26648166159394043 0.16278333700380257 3.73902056857547 0.09042866969983156 0.08502990824960381 1.7927195473781806e-07 6.746487646050031 -0.6792359154608116 S(ph)GSTESLNPR ddPTM_A459_Selumetinib_30min_R2 1 SGSTESLNPR 10 0 Q96JB2 Q96JB2 COG3 Conserved oligomeric Golgi complex subunit 3 1 S(0.649)GS(0.338)T(0.013)ESLNPR 87.001 0.034268 2247700.0 15259.0 9627.9 12261.0 12798.0 14884.0 12679.0 12063.0 14048.0 13597.0 8396.7 True False 14410.965866616762 10366.328971422134 11472.140608767433 11054.890322218593 13014.138855351748 14425.417161497515 12623.953402381028 14088.877354228405 16316.779931922603 8154.265453753382 1.7672917258271794 1.271276858745204 1.4068882934742877 1.3557187198425167 1.5959915616140976 1.7690639633098457 1.5481410893448733 1.7277923356963245 2.0010116207845603 1.0 12.993339207711253 -6.422910797026937 5.389162066215157 1.6540568441242016 1.4358566086066256 0.06214911678164736 0.26880346259390175 0.47751511582287437 20.70463915496057 0.08036406975745367 0.09081679293468127 3.7764975125042015e-07 6.422910797026937 -0.21820023551757606 S(ph)GSTSSLSYSTWTSSHSDK ddPTM_A459_Selumetinib_30min_R1 1 SGSTSSLSYSTWTSSHSDK 19 0 Q9ULD2;Q9ULD2-5;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 S(0.471)GS(0.112)T(0.045)S(0.301)S(0.071)LS(0.001)YSTWTSSHSDK 92.136 0.0015332 3911400.0 1571.6 1852.6 1794.2 2090.0 2229.4 1863.6 2807.9 2580.7 953.28 1472.6 True False 1608.2152221987365 1635.696730749625 1550.5574948351382 1725.0207341589366 2027.7511636325398 1844.8538760134145 2596.09784234674 2512.2514527049893 1617.6465351835316 1661.6225543386963 0.9678583249845117 0.984397284737514 0.9331586711954807 1.0381543808819278 1.22034402959796 1.1102725292192737 1.562387219388673 1.5119266683912052 0.9735342909011808 1.0 10.698376988776104 -6.336033943023316 1.587689344659558 1.2883388857994864 0.9604679671937552 0.2940627867525626 0.1835855269627443 0.42798068677396245 2.1511778039027503 0.06945920622771906 0.0886132646721192 4.612815209102667e-07 6.336033943023316 -0.32787091860573125 S(ph)GSTSSLSYSTWTSSHSDK ddPTM_A459_Selumetinib_30min_R2 1 SGSTSSLSYSTWTSSHSDK 19 0 Q9ULD2;Q9ULD2-5;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 S(0.293)GS(0.293)T(0.094)S(0.132)S(0.188)LSYSTWTSSHSDK 161.97 7.9388e-07 9749600.0 22936.0 21147.0 26720.0 47110.0 39761.0 32835.0 29368.0 50255.0 44446.0 70310.0 True False 21661.308940082705 22768.90690167783 25000.864290536338 40693.536730717125 34765.86771215001 37357.72320354686 30733.670191587997 50401.233729836866 53336.44192500051 68279.96761268123 0.3172425192547936 0.3334639382202797 0.36615225760436765 0.5959806097382999 0.5091664353058825 0.5471256725758704 0.4501125478841032 0.7381555014164382 0.7811433395450916 1.0 16.059174753599997 -7.781601843548651 0.14805702704646928 1.2898421895405028 2.4586702937219918e-20 0.8672751779376469 0.07624892912124116 1.7574754206905945 0.25908761196255303 0.91394916499361 1.0177914772303267 1.6534769932660618e-08 7.781601843548651 -1.2898421895405028 down S(ph)GSYSYLEER ddPTM_A459_Selumetinib_30min_R2 1 SGSYSYLEER 10 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;H0YIM2;H0YIS3;A0A0U1RQZ1 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 S(0.619)GS(0.381)YSYLEER 136.49 0.0018501 4066600.0 9574.0 10855.0 12988.0 11618.0 13044.0 9292.0 8681.1 8642.0 6812.5 8768.9 True False 9041.915407758623 11687.543595673744 12152.36622026519 10035.608357832129 11405.296105160443 10571.88865562228 9084.788351273313 8667.14678923988 8175.190357153992 8515.719072661637 1.0617911805928704 1.372467021979946 1.4270510941675414 1.178480439784569 1.339322728690679 1.2414557790617646 1.0668257458654997 1.017782140919183 0.960011748555579 1.0 13.055912641784024 -7.334147680404876 2.2209013659289685 0.9913272908814629 1.2862022414471177 0.6377593037230302 0.09691967638714086 0.201341663886064 1.9401323650065654 0.04930716462378554 0.03028859569147653 4.632893529327189e-08 7.334147680404876 0.2948749505656548 S(ph)GTATPQR ddPTM_A459_Selumetinib_30min_R2 1 SGTATPQR 8 0 Q13131;Q13131-2 Q13131 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 S(0.994)GT(0.005)AT(0.001)PQR 81.97200000000002 0.042442 1071100.0 3408.2 3708.1 4789.6 4771.5 5011.7 2732.9 6188.1 13810.0 6326.2 6847.6 True False 3218.78588810559 3992.4993465792545 4481.442350522185 4121.613468703391 4382.085440833535 3109.332168203847 6475.858911487532 13850.18481363143 7591.61676879671 6649.891995798542 0.48403581443717375 0.6003855925933458 0.6739120505045192 0.619801565394966 0.6589709191671345 0.46757634111476537 0.9738291863355126 2.082768385168074 1.1416150478223042 1.0 12.699115193938894 -7.5281230110558575 24.94833909577374 1.4729749972940664 0.6045217373328348 0.6446957700101668 0.2732496933289826 76.38945990736046 363396.4676250619 0.11859832630778354 0.06876166502802339 2.9639917394497948e-08 7.5281230110558575 -0.8684532599612317 S(ph)GTFDLLEMDR ddPTM_A459_Selumetinib_30min_R1 1 SGTFDLLEMDR 11 0 H0YA31;H0YA26;E9PHT6;Q9NVE7 H0YA31 PANK4 Pantothenate kinase 4 1 S(0.66)GT(0.34)FDLLEMDR 150.14 0.00061878 2676000.0 826.04 1071.1 710.64 597.59 661.86 879.38 895.79 888.39 577.94 1006.2 True False 845.2851248059583 945.695114059119 614.1389912661034 493.23212465360723 601.9948798608739 870.534235613156 828.2198390953332 864.8270113025866 980.7219689324965 1135.3555712179807 0.7445113638709306 0.832950608631445 0.5409221629196488 0.43442965107792647 0.5302258562179503 0.7667503094905053 0.7294805786761939 0.7617234928215678 0.8638016087598027 1.0 10.14892847688901 -8.162133029853843 0.859537523485431 0.9919104906989242 0.6284131860456726 0.5223427151110012 0.11273751971768477 0.5200737622524544 0.7893971882618844 0.12142950449138187 0.04617292172101259 6.884413858014705e-09 8.162133029853843 -0.3634973046532516 S(ph)GTNSPPPPFSDWGR ddPTM_A459_Selumetinib_30min_R2 2 SGTNSPPPPFSDWGR 15 0 D6RAU6;D6REP2;D6RAJ6;Q9UKT5-2;Q9UKT5 D6RAU6 FBXO4 F-box only protein 4 1 S(0.746)GT(0.162)NS(0.091)PPPPFSDWGR;S(0.971)GT(0.011)NS(0.018)PPPPFSDWGR 112.24 0.0036547 14470000.0 81814.0 65311.0 82997.0 82925.0 84964.0 60808.0 65569.0 64355.0 54008.0 67528.0 True False 77267.10540739122 70320.14369203578 77657.06338030106 71630.47194639611 74290.0627322027 69183.75003993536 68618.0884225087 64542.26239545624 64811.10910960328 65578.29118118531 1.1782421288458258 1.0723082658215244 1.1841885779814463 1.0922893941912777 1.1328453577258937 1.0549794572839444 1.0463537122814741 0.9842016501639751 0.9883012799241384 1.0 16.00093068846936 -7.136733860669184 1.1164976714165706 0.9868886111649305 1.1345715990961724 0.7668474448478665 0.033735981863826335 0.22290171184410157 0.5550290184018405 0.020208023774033353 0.01280416572272892 7.299046649811016e-08 7.136733860669184 0.1476829879312419 S(ph)GTPTQDEMMDKPTSSSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R2 1 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.425)GT(0.425)PT(0.135)QDEMMDKPT(0.004)S(0.003)S(0.003)S(0.004)VDTMSLLSK 69.523 0.00053097 19210000.0 33252.0 38524.0 36639.0 35236.0 37061.0 29889.0 32348.0 32351.0 22452.0 29818.0 True False 31403.98695830264 41478.666925816244 34281.686629526965 30436.796014509608 32405.065850456245 34005.93844467222 33852.24609634598 32445.136054003633 26943.027361294877 28957.076863531904 1.0845012811998416 1.4324189945447787 1.1838793947016384 1.0511004324763609 1.1190724120108506 1.1743567420473568 1.1690491500880387 1.1204561913106823 0.9304470713073428 1.0 14.821628353264206 -6.984153256108192 0.2897584194114769 0.9677937114998963 1.2879063313293164 0.32700989551482706 0.10472341169930593 2.8379710260220112 0.5691500095412002 0.1672200836125427 0.32163512260183263 1.0371623519572915e-07 6.984153256108192 0.3201126198294201 S(ph)GVSITIDDPVR ddPTM_A459_Selumetinib_30min_R2 1 SGVSITIDDPVR 12 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 S(0.696)GVS(0.304)ITIDDPVR 110.98 0.0069919 1458800.0 14184.0 17647.0 16879.0 20224.0 19100.0 14285.0 15636.0 15357.0 13573.0 16093.0 True False 13395.7100630508 19000.468155951592 15793.023516465673 17469.456311654056 16700.487243833526 16252.62908368105 16363.104982146213 15401.686327511794 16287.97926130658 15628.353275364496 0.8571414932222522 1.215769046243834 1.0105366341673856 1.1178053121688614 1.068601851364537 1.0399450791338727 1.0470140195729982 0.9854964279435631 1.0422070050708334 1.0 13.931878152344916 -7.401941723509785 1.9295953460507311 1.010962402179625 1.062563341232275 0.03594698936898755 0.0859746492725601 1.0648408000098053 7.740836346117282 0.045187868265334344 0.025418331778059553 3.963312130165084e-08 7.401941723509785 0.05160093905264995 S(ph)HEAEVLK ddPTM_A459_Selumetinib_30min_R1 2 SHEAEVLK 8 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 S(1)HEAEVLK;S(1)HEAEVLK 155.11 0.00041145 17372500.0 26600.0 20774.0 22240.0 21657.0 18075.3 16439.8 17707.9 17494.1 11853.8 17506.9 True False 27219.728245410013 18341.770422429418 19219.93015557545 17875.01150223928 16440.392306453414 16274.430538144108 16372.17884628792 17030.09963915464 20115.032832702393 19754.081146646855 1.3779293525900298 0.928505369916577 0.9729599677602785 0.9048768894661274 0.8322529498793761 0.8238515584363995 0.828799817351515 0.8621053802872225 1.01827225895125 1.0 14.269863121030516 S(ph)HEAEVLK ddPTM_A459_Selumetinib_30min_R2 4 SHEAEVLK 8 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 S(1)HEAEVLK;S(1)HEAEVLK;S(1)HEAEVLK;S(1)HEAEVLK 132.32 0.0022124 31433500.0 262429.0 239060.0 254890.0 255269.0 277894.0 213288.0 224320.0 235945.0 188095.0 244081.0 True False 247844.24676652282 257395.13330094566 238490.6549032481 220500.92183641277 242982.47131611925 242666.48596430992 234751.32448164764 236631.56088720277 225719.25581341327 237033.74733140197 1.045607427452119 1.085900789228447 1.0061464141214 0.9302511744377298 1.0250965276113204 1.0237634459072729 0.9903708949655881 0.9983032523903151 0.9522663264392911 1.0 17.85473294976969 -5.375450260289461 5.319915534554637 0.9900541897065002 1.065025679581861 0.5218131479307426 0.02900826879460464 0.16850715188017845 6.6732025672037105 0.007780508101599412 0.016663356127001518 4.212595308100052e-06 5.375450260289461 0.07497148987536073 S(ph)HESLLSPCSTVECLDLGR ddPTM_A459_Selumetinib_30min_R1 2 SHESLLSPCSTVECLDLGR 19 0 Q9UJF2-2;Q9UJF2 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.736)HES(0.261)LLS(0.003)PCSTVECLDLGR;S(0.5)HES(0.5)LLS(0.001)PCSTVECLDLGR 116.35 0.00030933 6325600.0 1373.08 1535.98 1787.41 1711.0099999999998 2179.69 1278.08 1947.19 1487.41 407.97 1049.47 True False 1405.070092451413 1356.1467475422705 1544.6895395403376 1412.214223135542 1982.5374243555254 1265.2236756037921 1800.311890608338 1447.9590550114028 692.2952930501269 1184.1796972034724 1.1865345232396651 1.1452204008774267 1.3044384591191993 1.192567501765644 1.674186298783397 1.0684389190185501 1.5203029530567929 1.2227528122892706 0.5846201338234672 1.0 10.20967230869743 -8.147744001584599 6.024096691570285 0.7986431260375972 1.2991824683857505 0.5129357532483746 0.19454901853151 0.16778957382297374 7.5697512670577565 0.12865173813691438 0.047312973462055506 7.1163286782849145e-09 8.147744001584599 0.5005393423481532 S(ph)HHAASTTTAPTPAAR ddPTM_A459_Selumetinib_30min_R1 1 SHHAASTTTAPTPAAR 16 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 S(1)HHAASTTTAPTPAAR 121.92 0.00098329 1845800.0 458.06 450.65 730.93 596.09 797.05 599.23 643.7 586.63 317.24 445.14 True False 468.7319067703951 397.8876884984986 631.673720711095 491.9940714951202 724.9569682306064 593.202290257308 595.1451907541567 571.0706667572084 538.3331097071409 502.27805503078093 0.9332119969718167 0.7921661806907232 1.2576175972338357 0.9795253178341018 1.4433379299961238 1.1810237065223863 1.1848918836752378 1.1369612130918434 1.0717830578406427 1.0 8.972342433548395 -5.259207759828538 24.998817611389388 1.1675415083353466 0.8626890712936711 0.4500344521359545 0.12966581771799374 157.52028394770227 1764529.4780404242 0.0323099201144391 0.07734030055329706 5.505442614561973e-06 5.259207759828538 -0.30485243704167553 S(ph)HHAASTTTAPTPAAR ddPTM_A459_Selumetinib_30min_R2 1 SHHAASTTTAPTPAAR 16 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 S(0.999)HHAAST(0.001)TTAPTPAAR 108.97 0.0020185 1553000.0 3285.9 2196.7 3595.7 2869.9 3633.0 978.65 2210.0 3419.5 1028.8 1119.6 True False 3103.2828324998995 2365.179826496223 3364.3565767021496 2479.0146691463597 3176.5900605679176 1113.4501541998222 2312.7693790319213 3429.4501788713023 1234.5887470737655 1087.2742389298508 2.8541859278798922 2.175329591938231 3.094303586198746 2.2800270441304016 2.9216088699889324 1.0240748049873187 2.1271260701515966 3.1541722006094224 1.1354897438652727 1.0 10.086500156254685 -6.732002957938327 24.999924683339664 1.8502419164268904 2.640334854212149 0.340019707167181 0.6610765890397746 295.76627102413426 251189.28239905005 0.2150077217770462 0.2149767537884733 1.8535189992305596e-07 6.732002957938327 0.7900929377852588 S(ph)HIASPSPCPDR ddPTM_A459_Selumetinib_30min_R1 1 SHIASPSPCPDR 12 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 S(0.716)HIAS(0.272)PS(0.012)PCPDR 132.56 0.0018656 10889000.0 2746.8 3564.2 2631.3 3103.3 3264.7 2685.9 3138.3 2956.3 1122.0 2642.2 True False 2810.7950956576037 3146.9018070483735 2273.9839126962975 2561.3669111557087 2969.408461429598 2658.882284602079 2901.575504340174 2877.889320584245 1903.9520523622882 2981.3521072074614 0.942792060307961 1.0555283958042707 0.7627357758913846 0.859129287333612 0.9959938828597302 0.8918377263035094 0.9732414689716031 0.9652966899236446 0.6386203252408386 1.0 11.541751056946438 S(ph)HLDSPEAR ddPTM_A459_Selumetinib_30min_R1 1 SHLDSPEAR 9 0 K7ER08;K7EP90;Q9BTD8-4;Q9BTD8-2;Q9BTD8-3;Q9BTD8 K7ER08 RBM42 RNA-binding protein 42 1 S(0.975)HLDS(0.025)PEAR 103.55 0.010017 3566800.0 2301.2 3234.4 3286.4 3157.8 2893.0 2431.6 2955.7 2495.4 1526.4 2520.8 True False 2354.8134826442683 2855.714944368234 2840.1249309030195 2606.349509247413 2631.3286608006356 2407.140311716152 2732.749169352277 2429.2138857984387 2590.189316154898 2844.3692346713224 0.8278860050728878 1.003988831533759 0.9985078225018865 0.9163189776761127 0.9251009428474203 0.8462826423427781 0.9607575331787248 0.854043088424539 0.9106375095686914 1.0 11.473893041621047 -5.97331369171896 24.736409759958832 0.9087712707419705 0.9508303263948743 0.02726158732863848 0.06197553761823267 497.3832188384893 461036.8923223847 0.016829308795849884 0.024961139127159727 1.0633746632515791e-06 5.97331369171896 0.0420590556529038 S(ph)HLLSETPQLYYK ddPTM_A459_Selumetinib_30min_R1 1 SHLLSETPQLYYK 13 0 Q6WRI0 Q6WRI0 IGSF10 Immunoglobulin superfamily member 10 1 S(1)HLLSETPQLYYK 88.18700000000003 0.024132 2472000.0 672.72 564.68 497.98 659.17 430.81 544.83 370.11 362.33 336.4 412.57 True False 688.3930671147453 498.56700308739005 430.35705120833904 544.0583336533717 391.84331156568334 539.3495048660601 342.19230472272966 352.7198313862902 570.8462303161083 465.5273782721147 1.4787380919889936 1.0709724633981952 0.9244505721783403 1.168692453004028 0.8417191552086098 1.1585774114251863 0.7350637592848686 0.7576779537553104 1.226235570579979 1.0 8.862722206830343 -4.755254202682912 2.821892943600353 0.9678460689537427 1.5920130519170865 0.4625258741445669 0.16154946347329388 0.4130435956132644 4.2855898102307854 0.040699025911913114 0.6222324531543373 1.7568949613698163e-05 4.755254202682912 0.6241669829633438 S(ph)HSAGEVGEDSR ddPTM_A459_Selumetinib_30min_R2 1 SHSAGEVGEDSR 12 0 A0A2R8Y6F3;Q9P2P5;A0A2R8YE75 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 S(0.725)HS(0.275)AGEVGEDSR 118.76 0.004442 4423600.0 10205.0 7838.1 11517.0 11185.0 10441.0 9627.2 5836.1 7218.2 7020.8 10278.0 True False 9637.846953851762 8439.257066536193 10776.008758761482 9661.583704798792 9129.308236275705 10953.259412979645 6107.490214012759 7239.203766962665 8425.156177542267 9981.24743454896 0.9655954345437268 0.8455112571725912 1.0796254505685876 0.9679735692511049 0.9146460195622078 1.0973838174841928 0.6118964842883637 0.7252804636327298 0.8440985190267442 1.0 13.285004416374289 -7.255016191412709 24.999659238654026 0.7724255712683112 0.973634676003443 0.37315993124681746 0.1146556840533239 499.8159524408178 1945336.313791083 0.04323686538804651 0.032663064828602706 5.558835323755509e-08 7.255016191412709 0.20120910473513176 S(ph)HSDNDRPNCSWNTQYSSAYYTSR ddPTM_A459_Selumetinib_30min_R1 1 SHSDNDRPNCSWNTQYSSAYYTSR 24 1 O75494-6;O75494-3 O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.742)HS(0.245)DNDRPNCS(0.012)WNT(0.001)QYSSAYYTSR 64.726 0.001663 9893300.0 664.65 459.32 494.86 541.14 759.36 349.49 767.7 646.39 59.663 425.96 True False 680.135051816232 405.54260086792533 427.660730071406 446.64005745586957 690.6760220758973 345.97444791153066 709.7917709211846 629.245637429371 101.24375338689052 480.6361152017598 1.4150727136489258 0.8437622310127236 0.8897806813619988 0.9292686157559769 1.4370040041330803 0.719826157396222 1.4767757737539773 1.309193415824003 0.21064533060398666 1.0 8.908801247033393 -8.247101808573236 24.925895860459264 0.6053225883365678 1.1119489437330867 0.3051045607319516 0.31456392519589116 808.8555912274052 1406203.5755161592 0.20696001263623082 0.07741750494890676 5.661065651376527e-09 8.247101808573236 0.5066263553965189 S(ph)HSDNDRPNCSWNTQYSSAYYTSR ddPTM_A459_Selumetinib_30min_R2 2 SHSDNDRPNCSWNTQYSSAYYTSR 24 1 O75494-6;O75494-3 O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.864)HS(0.132)DNDRPNCS(0.002)WNT(0.001)QY(0.001)SSAYYTSR;S(0.571)HS(0.214)DNDRPNCS(0.214)WNTQYSSAYYTSR 70.718 0.00059654 42602000.0 13461.0 3993.0 4365.8 13846.3 13835.6 11631.0 9924.0 14028.0 5354.2 16111.7 True False 12712.891508652476 4299.250260481368 4084.909181123631 11960.410053800224 12097.448236166658 13233.064674294317 10385.485664032944 14068.819157539576 6425.189608847542 15646.513357776072 0.8125063532019655 0.274773693165622 0.26107472557734374 0.7644137566185688 0.7731721412652242 0.8457516618370247 0.6637571851668487 0.8991664044147953 0.4106467339993241 1.0 13.933553584831275 -5.780914840943398 24.99908742910823 0.7605238838791837 0.4319838310307504 0.33454483849797134 0.20359509922994914 246.0427062117132 315824.45806467615 0.05510332082835941 0.08186435834098249 1.6560946685699929e-06 5.780914840943398 -0.3285400528484333 S(ph)HSFSDPSPK ddPTM_A459_Selumetinib_30min_R2 2 SHSFSDPSPK 10 0 G5E948;A0A0D9SEY1;O95819-3;H7C0P6;O95819-5;H7C3Z6 G5E948 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 1 S(0.637)HS(0.309)FS(0.055)DPSPK;S(0.556)HS(0.38)FS(0.064)DPSPK 93.839 0.016309999999999998 9006200.0 188872.0 155074.0 177083.0 191343.0 176924.0 157784.0 184463.0 169190.0 125148.0 167367.0 True False 178375.25035452127 166967.67715849963 165689.6725733925 165281.753314914 154697.225399372 179517.31377945605 193040.8950065002 169682.3148890877 150181.09692728173 162534.6798383106 1.0974596346574703 1.0272741628100475 1.0194111972793776 1.0169014605334454 0.9517798020291097 1.1044862176985228 1.1876904990278823 1.0439760613420321 0.9239941720541228 1.0 17.310388051609834 -8.174372263831199 6.862743509652177 0.9627564184196207 1.0555696145952391 0.2677868804632717 0.06239818900472365 0.34727005594561067 22.860915833156493 0.046948843188063964 0.017422845383482207 6.693106510212177e-09 8.174372263831199 0.09281319617561845 S(ph)HSGPAGSFNKPAIR ddPTM_A459_Selumetinib_30min_R1 1 SHSGPAGSFNKPAIR 15 1 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 S(0.836)HS(0.164)GPAGSFNKPAIR 81.789 0.014637 106950000.0 1437.3 1652.6 2341.4 2052.8 1796.4 1856.9 1783.7 1856.4 760.61 1466.2 True False 1470.7862935010462 1459.112823727104 2023.4507403895836 1694.317015828452 1633.9159371801795 1838.2212719303027 1649.154072934892 1807.1622415629652 1290.699617243564 1654.4010519974186 0.8890143606505281 0.881958351008943 1.2230714783133134 1.0241271388112583 0.987617805977271 1.111109830177484 0.9968284721191444 1.0923362502587342 0.7801612648186215 1.0 10.692093292806064 -1.8287722147646872 14.962207477814305 1.007658951491699 0.005040544784267409 0.0 0.1211429200600372 0.0 0.0 0.027276240732973602 0.0 0.014832958622540747 1.8287722147646872 -1.0026184067074315 S(ph)HSGPAGSFNKPAIR ddPTM_A459_Selumetinib_30min_R2 1 SHSGPAGSFNKPAIR 15 1 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 S(0.963)HS(0.037)GPAGSFNKPAIR 78.501 0.018072 76186000.0 95262.0 58808.0 89677.0 92796.0 80978.0 59617.0 46003.0 55649.0 63181.0 66819.0 True False 89967.71940400054 63318.38450247646 83907.27945293512 80157.02471797114 70804.8196874949 67828.7006007569 48142.23065321519 55810.92937681211 75818.96542463802 64889.761853388496 1.3864701739432026 0.9757838940068482 1.2930742393925667 1.2352799953107765 1.091155486862024 1.0452912549441717 0.7419079570978767 0.8600883680681548 1.1684272412024397 1.0 15.985703250863056 -6.710251530887875 2.284349442618412 0.9311052918468778 1.2063343906411887 0.42217649140204305 0.14272005168877597 0.2899900981843614 3.103094877313373 0.05398208998470922 0.05147027582273287 1.9487156327435344e-07 6.710251530887875 0.2752290987943109 S(ph)HSGTSPDNTAPPPPPPRPQPSHSR ddPTM_A459_Selumetinib_30min_R2 1 SHSGTSPDNTAPPPPPPRPQPSHSR 25 1 E9PMG1;H0YDT0;Q96D71-4;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 S(0.25)HS(0.25)GT(0.25)S(0.25)PDNTAPPPPPPRPQPSHSR 90.744 1.9215e-05 5682200.0 3727.4 2200.3 3586.2 3432.6 3880.8 1911.9 953.11 4233.5 1111.8 3973.3 True False 3520.2460299644345 2369.0559349204004 3355.4677963593317 2965.073958434717 3393.2592092078107 2175.2468704998096 997.4315035516358 4245.818784106345 1334.1910662875318 3858.5805051268117 0.9123163363540453 0.6139708454372502 0.869611970490442 0.7684364637449155 0.8794060936915172 0.5637427721436955 0.25849700485097316 1.100357703685337 0.3457725099981253 1.0 11.913854491000416 -6.763314297249508 24.999648111269817 0.6352477905897563 0.7990691350370251 0.08307264910435685 0.25291826829690783 128.33142639100623 1711118.78107137 0.08268647922552025 0.07665066597982735 1.7245893615652529e-07 6.763314297249508 0.1638213444472688 S(ph)HSPSASQSGSQLR ddPTM_A459_Selumetinib_30min_R1 2 SHSPSASQSGSQLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.854)HS(0.146)PSASQSGSQLR;S(0.517)HS(0.457)PS(0.026)ASQSGSQLR 180.3 7.0942e-05 11532900.0 2213.66 2926.88 2330.76 3286.2 3532.11 2644.32 2970.0899999999997 2819.26 812.3299999999999 1832.6399999999999 True False 2265.233970967456 2584.1995289304036 2014.2555939482481 2712.326859613921 3212.6312741446714 2617.720541650458 2746.0537200668227 2744.484066552901 1378.4646797642213 2067.877195425281 1.0954393113763152 1.2496871355065817 0.9740692524702826 1.3116479380953288 1.5535890048267393 1.2658974853253293 1.3279578333480617 1.3271987681978707 0.6666085794716282 1.0 11.013934795841237 -8.252713745809912 24.887927611628143 0.8333042819629181 1.2666436384780695 0.529578543794224 0.1620379989561137 421.9149511923042 1203427.3278532175 0.11770609525548893 0.04295853975613373 5.588384175368355e-09 8.252713745809912 0.43333935651515143 S(ph)HSPSIDGTPK ddPTM_A459_Selumetinib_30min_R1 2 SHSPSIDGTPK 11 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 S(0.893)HS(0.107)PSIDGTPK;S(0.894)HS(0.102)PS(0.004)IDGTPK 125.36 0.0033649 23932000.0 11515.3 14467.6 14125.5 14020.0 13100.8 11797.0 13224.2 12262.7 6240.3 10839.4 True False 11783.584085126695 12773.726666195227 12207.334685817488 11571.670187994396 11915.834953134105 11678.332890818989 12226.687947135506 11937.453361136697 10589.333326520838 12230.742574697044 0.9634397922416068 1.0443950224757006 0.9980861432789877 0.946113461003902 0.9742527798586473 0.9548343299268779 0.9996684888479358 0.9760203265035515 0.8657964356496267 1.0 13.578224377552987 -5.650920564435493 5.765973296764247 0.9607377677256298 1.0078524533561855 0.18905035728527386 0.04007992259804791 0.3206013453407561 14.968492593868476 0.010699202362009889 0.018731862043893568 2.2339807965171135e-06 5.650920564435493 0.04711468563055565 S(ph)HSPSIDGTPK ddPTM_A459_Selumetinib_30min_R2 3 SHSPSIDGTPK 11 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 S(0.882)HS(0.118)PSIDGTPK;S(0.659)HS(0.338)PS(0.003)IDGTPK;S(0.881)HS(0.117)PS(0.002)IDGTPK 133.15 0.0012408 27260300.0 203214.0 170907.0 201204.0 200573.0 211410.0 151922.0 171705.0 183449.0 151255.0 166265.0 True False 191920.1794100963 184015.01734738 188258.75369435124 173254.61139227604 184850.78577062016 172847.87648939388 179689.6227270027 183982.80621838316 181510.226417809 161464.4974416506 1.1886215387964878 1.1396624042005186 1.1659451871912798 1.0730198535122937 1.1448385787558086 1.0705008173815855 1.1128738860500167 1.13946291063068 1.1241494526275193 1.0 17.300857456721502 -14.522878745280336 0.14601620834389278 0.5763175860545805 1.1666610764109648 0.5902044809833662 0.03336176074563291 103.29233635987171 0.9038631302494253 12.84545771553205 0.18699464436371807 3.0000000000000132e-15 14.522878745280336 0.5903434903563843 S(ph)HSQASLAGPGPVDPSNR ddPTM_A459_Selumetinib_30min_R2 3 SHSQASLAGPGPVDPSNR 18 0 A6PVU7;Q9P2M7-2;Q9P2M7;A2A3M4 A6PVU7 CGN Cingulin 1 S(0.527)HS(0.442)QAS(0.031)LAGPGPVDPSNR;S(0.928)HS(0.069)QAS(0.003)LAGPGPVDPSNR;S(0.551)HS(0.441)QAS(0.008)LAGPGPVDPSNR 99.943 0.0019227 24773300.0 68041.0 45526.0 60521.0 64442.0 77368.0 46828.0 47805.0 52589.0 46433.0 63479.0 True False 64259.55360970382 49017.69781083769 56627.14475028252 55664.88843134942 67648.34016130431 53278.131937739985 50028.02722381045 52742.025283422394 55720.89744641926 61646.196331750616 1.0423928390308033 0.7951455357772226 0.9185829478519982 0.902973609787494 1.0973643823416614 0.8642565982663768 0.8115346963920258 0.8555600900271252 0.9038821656823041 1.0 15.911724260347688 S(ph)HSSPASLQLGTGAGAAGSPAQQHAHLR ddPTM_A459_Selumetinib_30min_R1 3 SHSSPASLQLGTGAGAAGSPAQQHAHLR 28 0 Q9GZV5;C9JR84;C9J038 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 S(0.7)HS(0.136)S(0.136)PAS(0.028)LQLGTGAGAAGSPAQQHAHLR;S(0.412)HS(0.412)S(0.155)PAS(0.018)LQLGT(0.003)GAGAAGSPAQQHAHLR;S(0.452)HS(0.452)S(0.088)PAS(0.008)LQLGT(0.001)GAGAAGSPAQQHAHLR 63.453 0.0008092 27380600.0 5316.299999999999 6172.400000000001 5868.1 6146.7 8142.900000000001 7106.8 7443.5 5691.799999999999 2447.92 4464.0 True False 5440.159446280947 5449.732538529091 5071.244251166018 5073.294232849153 7406.37613274576 7035.312044458118 6882.030802203768 5540.83497442797 4153.941450997049 5036.9978830422 1.0800400501648115 1.0819406053110372 1.0067989641685406 1.007205948989804 1.4703949266447824 1.3967272188347626 1.3662961474280435 1.1000272589119033 0.824685963236536 1.0 12.298348409320056 -8.051970111996978 5.80320477735345 0.9224030959009418 1.2020755693351668 0.33614290121344537 0.16065918601978105 0.28602230594706896 21.835431097566854 0.12479723241272242 0.04719616294176977 8.872170679230405e-09 8.051970111996978 0.27967247343422497 S(ph)HSSPASLQLGTGAGAAGSPAQQHAHLR ddPTM_A459_Selumetinib_30min_R2 3 SHSSPASLQLGTGAGAAGSPAQQHAHLR 28 0 Q9GZV5;C9JR84;C9J038 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 S(0.311)HS(0.311)S(0.311)PAS(0.068)LQLGTGAGAAGSPAQQHAHLR;S(0.304)HS(0.304)S(0.304)PAS(0.087)LQLGTGAGAAGSPAQQHAHLR;S(0.313)HS(0.313)S(0.313)PAS(0.062)LQLGTGAGAAGSPAQQHAHLR 128.51 1.7149e-12 55401000.0 50013.0 42101.0 84282.0 108990.0 123416.0 76091.0 48560.1 59499.0 60445.0 99227.0 True False 47233.47767790178 45330.011323948434 78859.38787930335 94145.37398176306 107911.37872696131 86571.84456467441 50818.240870012705 59672.13223941028 72535.68897441066 96362.05868729214 0.4901667556852513 0.47041347955267776 0.8183655367431769 0.9769962915308552 1.119853396627279 0.898401774972572 0.5273677374922504 0.6192492465634674 0.752741171811187 1.0 16.556177595315752 -5.268673255120136 8.117302940808054 0.831695774042034 0.479619746405749 0.42229856655457754 0.16770695804742916 0.1355736761511961 88.51498248865536 0.05016929422688612 0.11404435971783886 5.386749064138609e-06 5.268673255120136 -0.352076027636285 S(ph)HSSSEAYEPR ddPTM_A459_Selumetinib_30min_R1 2 SHSSSEAYEPR 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 S(0.918)HS(0.078)S(0.002)S(0.002)EAYEPR;S(0.637)HS(0.357)S(0.006)SEAYEPR 160.86 0.00060471 67162700.0 964.75 962.05 1050.48 1115.94 1319.07 1102.62 889.7 777.06 382.62 618.4100000000001 True False 987.2267979232828 849.4127387550884 907.830585873601 921.0620277881936 1199.7603514007233 1091.5286438988585 822.5892126984206 756.4498445533919 649.2781945408718 697.7889473235056 1.4147928277023702 1.2172917642406964 1.3010102687291734 1.3199722227201964 1.7193742549271078 1.5642676028125868 1.1788510205752167 1.0840668191362026 0.9304793333733568 1.0 9.446646935819691 -7.571437200151174 2.8693057933324853 1.0000506168941705 1.415453074846155 0.6495460548077556 0.13841662235415012 0.19449720982042154 3.2469454264103637 0.08444654784942611 0.045288339948081305 2.6826424950218303e-08 7.571437200151174 0.4154024579519844 S(ph)HSSSEAYEPR ddPTM_A459_Selumetinib_30min_R2 2 SHSSSEAYEPR 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 S(0.643)HS(0.337)S(0.004)S(0.015)EAYEPR;S(0.969)HS(0.029)S(0.002)SEAYEPR 182.41 3.6628e-05 12363000.0 18216.7 17711.5 28127.9 28583.8 37129.5 13256.0 12763.2 19911.3 15163.5 25279.8 True False 17204.288741227956 19069.915098551406 26318.181537341956 24690.637130194704 32464.96026805847 15081.89367401302 13356.714089801015 19969.238586506843 18196.623703589652 24549.906489191544 0.7007883614058732 0.7767815778421484 1.072027771223036 1.0057324308369613 1.3224066772861902 0.614336094544924 0.5440637460546541 0.8134140386766276 0.7412094914333374 1.0 14.58342990886186 S(ph)HSTEPNLSSFLNDPNPMK ddPTM_A459_Selumetinib_30min_R2 2 SHSTEPNLSSFLNDPNPMK 19 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(0.352)HS(0.295)T(0.352)EPNLSSFLNDPNPMK;S(0.432)HS(0.432)T(0.136)EPNLSSFLNDPNPMK 81.696 0.01043 2803700.0 22782.0 18464.6 26244.7 26811.0 28064.0 15079.0 16778.0 20333.1 15721.7 18012.8 True False 21515.867643571848 19880.775446953234 24556.144575068807 23159.295548445258 24538.34942465675 17155.99537646667 17558.210244976282 20392.265954674098 18866.479301000796 17492.723661125074 1.22998956939951 1.1365168645026529 1.4037919451983978 1.3239387986167803 1.4027746564812837 0.98075037991901 1.0037436470797707 1.1657570513157318 1.0785329755667887 1.0 14.094467317549588 -6.766096947075587 24.999997047551172 1.0534907875880883 1.2975157336757837 0.6746543309373891 0.0879834067189015 79.74596810273276 428042.17638371553 0.032869212889859376 0.029935171976148575 1.713574745420397e-07 6.766096947075587 0.24402494608769532 S(ph)HSVPENMVEPPLSGR ddPTM_A459_Selumetinib_30min_R1 1 SHSVPENMVEPPLSGR 16 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.596)HS(0.404)VPENMVEPPLSGR 132.15 0.00064287 10587000.0 638.08 470.94 411.02 472.94 608.7 368.12 412.94 373.45 189.65 291.03 True False 652.9460225124517 415.80212586593353 355.2057415712508 390.3499071833144 553.6431924747138 364.4170470262174 381.79160334009873 363.54489286343966 321.82219851203894 328.3865353722608 1.9883459039277247 1.2661972434240578 1.0816696280454605 1.1886903546176506 1.6859497355672661 1.109719820312097 1.1626286775348376 1.1070639435667577 0.9800103349158926 1.0 8.359251164180625 -4.764195313260471 4.3409881622733835 1.184852664570626 2.0600195961809695 0.6314440126245935 0.18713748398570007 0.14685733906041118 5.794727691564106 0.048766016761972834 0.4059261831141229 1.721094381049277e-05 4.764195313260471 0.8751669316103434 S(ph)HSVPENMVEPPLSGR ddPTM_A459_Selumetinib_30min_R2 2 SHSVPENMVEPPLSGR 16 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.914)HS(0.086)VPENMVEPPLSGR;S(0.891)HS(0.109)VPENMVEPPLSGR 147.25 0.0002136 18788200.0 89003.0 92725.0 105106.0 121632.0 140562.0 59343.0 84676.0 84101.0 70316.0 93215.0 True False 84056.56956723833 99836.70934213258 98343.59439076032 105065.51177309692 122903.34491977635 67516.95958788127 88613.60178231093 84345.71998632986 84381.16479319496 90523.64074834401 0.9285593119361587 1.102879960602545 1.0863857615289225 1.1606416943081128 1.3576933484309144 0.7458489189092451 0.9789001088528576 0.9317535097910081 0.932145062832535 1.0 16.466006988722917 -6.771888382193373 24.99994734163722 0.9172873234881502 1.1254660043172946 0.44571551125919706 0.11680555618381018 208.80841306146155 499585.3563577644 0.041669693899577004 0.03714106298229891 1.6908754468527938e-07 6.771888382193373 0.20817868082914437 S(ph)HSWVNSAYAPGGSK ddPTM_A459_Selumetinib_30min_R2 1 SHSWVNSAYAPGGSK 15 0 K7ESB7;K7EKT0 K7ESB7 DOCK6 1 S(0.5)HS(0.5)WVNSAYAPGGSK 155.94 0.00014883 0.0 76086.0 52552.0 65965.0 73568.0 56474.0 51664.0 56703.0 60650.0 52166.0 59667.0 True False 71857.44471639051 56582.569418686944 61720.88371726147 63547.91148812142 49379.23123603429 58780.247040902854 59339.801854862955 60826.48145885199 62600.65763982308 57944.25867651613 1.2401132805503157 0.9765000141699792 1.0651768635410284 1.0967076452369275 0.852185054462469 1.0144274581033779 1.0240842356123268 1.0497413004871865 1.0803599712838179 1.0 15.82237810050064 -4.754846974115419 24.998752080799342 1.018120939752431 1.2401136544383544 0.5092421817456513 0.06550441121177196 194.62973408458552 737979.0177304328 0.016693311821318394 0.15689749375032208 1.7585431364853897e-05 4.754846974115419 0.22199271468592352 S(ph)HTNTSHVMQY(ph)GNKTIST(ph)MK ddPTM_A459_Selumetinib_30min_R2 1 SHTNTSHVMQYGNKTISTMK 20 1 Q99538-3;Q99538-2;Q99538 Q99538-3 LGMN Legumain 3 S(0.255)HT(0.255)NT(0.254)S(0.255)HVMQY(0.957)GNKT(0.092)IS(0.105)T(0.827)MK 49.993 0.029805 5242200.0 5258.7 6100.9 5574.9 7239.4 4680.1 4413.5 5282.9 3784.4 3237.6 4480.7 True False 4966.442506244021 6568.819412514595 5216.217003492175 6253.381231338433 4092.1439973751453 5021.419563236001 5528.565317867754 3795.4119774588517 3885.210466102275 4351.330548743289 1.1413618089019653 1.5096116782972833 1.1987636758597147 1.437119327361714 0.9404351040527134 1.1539963482402504 1.2705459297879502 0.8722417051389045 0.8928787235491373 1.0 12.08724090000505 -6.940740328838608 0.6288643097273539 0.9263291862830921 1.3381984264373148 0.42015805302965925 0.1593185137249766 0.7516655770137335 0.6342240232605048 0.1316478087720966 0.12144920720357841 1.1461980655558242e-07 6.940740328838608 0.41186924015422266 S(ph)HTSEGAHLDITPNSGAAGNSAGPK ddPTM_A459_Selumetinib_30min_R1 3 SHTSEGAHLDITPNSGAAGNSAGPK 25 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 S(0.839)HT(0.134)S(0.027)EGAHLDITPNSGAAGNSAGPK;S(0.457)HT(0.457)S(0.086)EGAHLDITPNSGAAGNSAGPK;S(0.786)HT(0.174)S(0.039)EGAHLDITPNSGAAGNSAGPK 185.72 1.4313999999999998e-26 18173000.0 5359.03 6242.6 5802.1 6716.0 8442.08 5859.1 7248.4 5071.0 2264.89 3680.3100000000004 True False 5483.884972142843 5511.713489893993 5014.206688653967 5543.176674933692 7678.4953545702765 5800.1627736371565 6701.6473522796805 4936.500607070563 3843.352908979339 4152.713637755163 1.3205545699768677 1.3272558550108613 1.2074530357851745 1.3348323911711313 1.8490307842948326 1.3967162871294339 1.6137995385355772 1.1887409144202614 0.9255039581917679 1.0 12.01983867469241 -7.995932168492608 4.689753295196576 0.9827722753012852 1.4331226943065627 0.5510715112775062 0.17215016807831682 0.15336700802882608 8.967578325860647 0.1182065074903977 0.04886033819779407 1.009410531393343e-08 7.995932168492608 0.4503504190052775 S(ph)HTSEGAHLDITPNSGAAGNSAGPK ddPTM_A459_Selumetinib_30min_R2 1 SHTSEGAHLDITPNSGAAGNSAGPK 25 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 S(0.744)HT(0.201)S(0.055)EGAHLDITPNSGAAGNSAGPK 109.28 1.1577e-07 9382400.0 36773.0 27973.0 46431.0 63770.0 72595.0 48438.0 34169.0 43403.0 44808.0 59074.0 True False 34729.30387398244 30118.439152628438 43443.68001025045 55084.415990614085 63474.96709246563 55109.894823615134 35757.92620458903 43529.29554424657 53770.85204012565 57368.38012731514 0.605373618653851 0.5250006900279893 0.757275696365102 0.9601877527022316 1.1064451698234883 0.9606318794658687 0.6233037454645403 0.7587680782975553 0.9372907500751171 1.0 15.807968161696854 -5.470432545521081 3.680964992657503 0.8945510600130511 0.5690157854419245 0.5303816279696286 0.12765163170747415 0.20556543836068328 5.582358185859196 0.03921368755881854 0.08466534571901323 3.385068445573835e-06 5.470432545521081 -0.3255352745711265 S(ph)IDDLEEK ddPTM_A459_Selumetinib_30min_R1 2 SIDDLEEK 8 0 P09493-3;P09493-9;Q6ZN40;P09493-2;H7BYY1;P09493-8;P09493-7 P09493-3 TPM1 Tropomyosin alpha-1 chain 1 S(1)IDDLEEK;S(1)IDDLEEK 123.96 0.005656899999999999 10964000.0 3661.5 3878.1 4384.6 4465.5 3112.0 3698.2 3133.0 3361.3999999999996 2365.51 3550.3 True False 3746.80582596123 3424.0502491202215 3789.1954028838195 3685.684252816618 2830.5201494682265 3660.999465696938 2896.6752876072287 3272.244752633997 4014.0976999853083 4006.015587850523 0.9352948693770872 0.8547271407292346 0.9458763501509386 0.920037421720123 0.7065674327510485 0.9138754918478219 0.723081382007671 0.8168327558579871 1.0020174939307018 1.0 11.967952319509886 S(ph)IDDLEEK ddPTM_A459_Selumetinib_30min_R2 4 SIDDLEEK 8 0 P09493-3;P09493-9;Q6ZN40;P09493-2;H7BYY1;P09493-8;P09493-7 P09493-3 TPM1 Tropomyosin alpha-1 chain 1 S(1)IDDLEEK;S(1)IDDLEEK;S(1)IDDLEEK;S(1)IDDLEEK 131.09 0.0036569 31273200.0 107134.0 113771.0 116219.0 113524.0 109215.0 93676.0 124186.0 106522.0 86259.0 113301.0 True False 101179.92117138217 122496.86986857635 108741.59606967944 98061.83536017667 95494.43530551191 106579.01869393823 129960.89506989073 106831.96138433355 103513.21027783424 110029.70573864884 0.9195691335548295 1.1133072568560756 0.9882930735811561 0.8912305518029904 0.8678968526221251 0.9686385869929802 1.1811437120315853 0.970937445184932 0.9407751259801321 1.0 16.747533548515428 -7.030876404458214 24.99763766474683 1.028520606083686 0.9585128030565659 0.12026759022598399 0.08615409205568729 1568.1792542326477 1269598.169574328 0.03515995819594637 0.027269180858897346 9.313728964709892e-08 7.030876404458214 -0.07000780302712006 S(ph)IDPDSIQSALLASGLGSK ddPTM_A459_Selumetinib_30min_R1 1 SIDPDSIQSALLASGLGSK 19 0 A3KN83-3;A3KN83-2;A3KN83 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 1 S(0.999)IDPDS(0.001)IQSALLASGLGSK 117.37 0.0013679 0.0 1007.9 872.88 1167.9 1152.6 1010.7 1059.9 820.94 1111.5 614.96 816.68 True False 1031.382108967998 770.6828038090972 1009.3055948154928 951.3200469816225 919.2823634535785 1049.238368312202 759.015834857414 1082.0194093391701 1043.5422050986738 921.5088331368513 1.1192319290712969 0.836327093236495 1.0952750082490017 1.0323504374269454 0.9975838867700336 1.138609127316289 0.8236663692888272 1.1741823522797223 1.1324277831894636 1.0 9.847854184672117 S(ph)IEDDEEGHLICQSGDVLR ddPTM_A459_Selumetinib_30min_R1 2 SIEDDEEGHLICQSGDVLR 19 0 A0A087WX74;B7ZL31;Q9HAZ1 A0A087WX74;Q9HAZ1 CLK4 Dual specificity protein kinase CLK4 1 S(1)IEDDEEGHLICQSGDVLR;S(1)IEDDEEGHLICQSGDVLR 175.34 3.2771e-11 37891000.0 1711.57 2089.87 1985.48 2261.7 2071.1000000000004 1750.27 1769.03 1869.6999999999998 890.04 1618.5700000000002 True False 1751.4462508645267 1845.1870488457955 1715.8627214609676 1866.7365523671133 1883.769370682404 1732.6638729180086 1635.5906428457758 1820.1094823584754 1510.332874050383 1826.329225706904 0.9589980964065267 1.0103255332463905 0.9395144628410691 1.0221248864068138 1.031451144824815 0.9487138729039168 0.8955617748561734 0.9965944018959554 0.8269773339830279 1.0 10.834731142799857 -6.966011344940516 9.78746917983387 0.9284444938270888 0.9920346683438351 0.24374341543086764 0.0527116061602807 0.5134894014701912 142.05300486932785 0.017573728161038544 0.015456921481060185 1.0814057017020644e-07 6.966011344940516 0.06359017451674631 S(ph)IEDDEEGHLICQSGDVLR ddPTM_A459_Selumetinib_30min_R2 2 SIEDDEEGHLICQSGDVLR 19 0 A0A087WX74;B7ZL31;Q9HAZ1 A0A087WX74;Q9HAZ1 CLK4 Dual specificity protein kinase CLK4 1 S(1)IEDDEEGHLICQSGDVLR;S(1)IEDDEEGHLICQSGDVLR 114.78 0.00031731 24686000.0 18466.2 17864.6 18951.9 22969.0 26076.0 15641.4 17949.8 23070.0 16855.4 17620.8 True False 17439.922530055595 19234.75737625733 17732.55538726854 19840.582576264944 22800.09975760225 17795.86087150778 18784.501266853942 23137.129880555894 20226.950979225458 17112.041719663386 1.019160823457755 1.124048064595047 1.036261813626373 1.15945150796741 1.3324008982167648 1.0399612835830465 1.0977358268866735 1.3520963926805474 1.1820302515966135 1.0 14.062724284502474 -5.851415696368227 5.974850263096104 1.180976986199775 1.0667568700100618 0.15925511536321335 0.10881537551240963 0.3567150421189768 19.019371236040605 0.030848311976388716 0.046474088091700436 1.4079405060192468e-06 5.851415696368227 -0.11422011618971317 S(ph)IEDLHR ddPTM_A459_Selumetinib_30min_R1 2 SIEDLHR 7 0 Q96PY5-3;Q96PY5 Q96PY5-3 FMNL2 Formin-like protein 2 1 S(1)IEDLHR;S(1)IEDLHR 109.48 0.015825 72930000.0 6661.9 5872.8 8041.6 6879.9 7744.5 5514.0 6308.2 7678.700000000001 3937.8999999999996 5197.3 True False 6817.10930819913 5185.20984580935 6949.59488934692 5678.454616717733 7044.011342402531 5458.534166311429 5832.367395239041 7475.035932067198 6682.328687163501 5864.424080989073 1.1624516259488145 0.8841805732669371 1.1850430312288782 0.9682885375097268 1.2011428991360584 0.9307877620935645 0.994533702660769 1.2746410949882199 1.139468871091001 1.0 12.517773719207776 -7.735834975917697 24.99978251172903 1.1552914553595457 1.044181814886917 0.10357073515910353 0.11989992963846317 388.8914690725481 379708.6932406587 0.05293180068517308 0.0305464479129155 1.8372363274485395e-08 7.735834975917697 -0.11110964047262861 S(ph)IEDLHR ddPTM_A459_Selumetinib_30min_R2 7 SIEDLHR 7 0 Q96PY5-3;Q96PY5 Q96PY5-3 FMNL2 Formin-like protein 2 1 S(1)IEDLHR;S(1)IEDLHR;S(1)IEDLHR;S(1)IEDLHR;S(1)IEDLHR;S(1)IEDLHR;S(1)IEDLHR 167.23 2.5581e-05 143711600.0 291208.3 181128.2 218616.69999999998 264178.8 191103.59999999998 206422.6 297778.69999999995 269077.7 205366.4 209376.4 True False 275024.10848518834 195020.15052104223 204551.13953386553 228197.19170615097 167095.45728013944 234855.43943220592 311625.99958729965 269860.6715587888 246445.41841664963 203331.15930678108 1.3525920445387256 0.9591257492748596 1.0059999669074025 1.1222932701714086 0.8217897239646871 1.1550391009076075 1.5326032697090266 1.3271978209283193 1.212039606998054 1.0 17.633471791108754 -7.0046549945406005 24.989722257423466 1.3021687472990104 1.042482495953001 0.2389446848913952 0.1768270485464635 236.1523541373224 1267757.8981687175 0.06127622810234889 0.052686454588169174 9.893387176223298e-08 7.0046549945406005 -0.2596862513460094 S(ph)IELEHFEER ddPTM_A459_Selumetinib_30min_R1 1 SIELEHFEER 10 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 S(1)IELEHFEER 99.011 0.012535 1928800.0 773.33 853.3 606.0 695.14 620.78 534.41 637.42 603.31 487.95 666.37 True False 791.347084361764 753.3952393115918 523.7085285197268 573.7468483938961 564.630558607611 529.0343206054571 589.3388962102141 587.3082589729329 828.0155115420484 751.9050804934657 1.052456094381505 1.0019818443268773 0.6965088308434139 0.7630575497872064 0.7509332936506442 0.7035918952140324 0.7837942733721636 0.7810936170127883 1.1012234562887013 1.0 9.55440673925137 -10.296959143348872 7.311588716945948 0.9999999986511043 0.8348495255540908 0.087000473927762 0.14152737308576505 4.1551288017817957e-10 1.4629238335469337e-10 0.14356327909090685 0.03481920936715529 5.04708776270551e-11 10.296959143348872 -0.16515047309701358 S(ph)IELEHFEER ddPTM_A459_Selumetinib_30min_R2 2 SIELEHFEER 10 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 S(1)IELEHFEER;S(1)IELEHFEER 104.17 0.0088865 3013100.0 12662.099999999999 11431.3 12488.900000000001 15029.3 12100.0 10069.0 11220.3 14858.8 10911.8 12398.2 True False 11958.391172402384 12308.043952577184 11685.377770886189 12982.283413011388 10579.88982462753 11455.913352718546 11742.066182602653 14902.036647993238 13094.46490116593 12040.231751607787 0.9932027405374091 1.0222431101406029 0.9705276453109623 1.0782419874333236 0.8787114768961776 0.9514695056587084 0.9752358945279174 1.23768686146787 1.0875592074394553 1.0 13.555575541055493 -7.725119830397259 24.985293876487233 1.1219673474636176 0.9811572514493332 0.389607673498918 0.07227317383803153 146.34429728579272 100674.52729020617 0.03310862017248888 0.019114533362812488 1.8831294253197957e-08 7.725119830397259 -0.1408100960142844 S(ph)IEVENDFLPVEK ddPTM_A459_Selumetinib_30min_R1 6 SIEVENDFLPVEK 13 0 Q5JPT2;Q96B97-2;Q96B97;Q5JPT1;Q5VSN0 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK 189.8 0.00011097 198672500.0 23417.799999999996 26609.09 30928.899999999998 30820.949999999997 27228.660000000003 23829.359999999997 27075.780000000002 25301.810000000005 14998.829999999998 20928.84 True False 23963.38917689332 23493.685372569653 26728.925260286745 25438.64966338558 24765.832510610366 23589.65827372774 25033.43211576445 24630.723806938306 25451.9190387995 23615.260478165088 1.0147416836265735 0.9948518414307628 1.1318496903729087 1.077212325771567 1.048721547387085 0.9989158618656346 1.0600531863246065 1.0430003018477025 1.0777742241010895 1.0 14.527431828164522 -10.562092184660225 4.52754548290203 0.9999977719063525 1.0498813748013691 0.12707446544709633 0.039059554201491944 9.17432313444002e-07 1.9473213151491125e-07 0.03949563681290764 0.009578671174591727 2.7409922988596866e-11 10.562092184660225 0.04988360289501659 S(ph)IEVENDFLPVEK ddPTM_A459_Selumetinib_30min_R2 9 SIEVENDFLPVEK 13 0 Q5JPT2;Q96B97-2;Q96B97;Q5JPT1;Q5VSN0 Q5JPT2 SH3KBP1 SH3 domain-containing kinase-binding protein 1 1 S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK;S(1)IEVENDFLPVEK 203.9 4.3511e-21 22617700.0 327506.6 325266.1 342540.3 365648.0 367821.4 285718.2 306791.3 301562.0 251947.3 326323.2 True False 309305.0942847965 350212.96397464594 320501.6300276802 315846.1116220171 321612.38736696285 325073.28855841816 321057.70334542845 302439.4954937237 302343.7999957413 316901.4013265045 0.9760294305739549 1.1051164889416834 1.0113607219346639 0.9966699746354226 1.0148657785063078 1.025786844733748 1.013115442221228 0.9543646516795279 0.9540626792124391 1.0 18.273674513716216 -7.675536559886742 5.152101070904937 0.9658396382551377 1.023118782171868 0.32397433042390444 0.03365141059342624 0.22123879471321345 9.830506187744712 0.016387848929769983 0.00910979533116211 2.110879489743422e-08 7.675536559886742 0.05727914391673017 S(ph)IFASPESVTGK ddPTM_A459_Selumetinib_30min_R1 1 SIFASPESVTGK 12 0 O75940 O75940 SMNDC1 Survival of motor neuron-related-splicing factor 30 1 S(0.847)IFAS(0.137)PES(0.016)VTGK 123.26 0.0033416 46157000.0 5383.0 6451.0 7351.8 7638.9 6352.0 5199.4 6261.0 5557.3 3573.2 5082.6 True False 5508.413426505342 5695.713921011465 6353.465940546742 6304.909514912295 5777.462721536683 5147.098756677478 5788.727729239985 5409.9023513455395 6063.459423797617 5735.001218716462 0.9604903672083557 0.9931495572177419 1.107840381936082 1.099373700974275 1.0074039221965019 0.8974886944887936 1.0093681776994543 0.943313199950168 1.0572725606420474 1.0 12.485578077483137 -6.520261348573405 24.99999906571929 0.9766612168568367 1.0431456030360462 0.18931271502324898 0.05671994127697713 166.42969223542687 1589668.5166405463 0.019228543447321042 0.019575286191203533 3.0181349286282825e-07 6.520261348573405 0.06648438617920949 S(ph)IFASPESVTGK ddPTM_A459_Selumetinib_30min_R2 1 SIFASPESVTGK 12 0 O75940 O75940 SMNDC1 Survival of motor neuron-related-splicing factor 30 1 S(0.556)IFAS(0.442)PES(0.002)VTGK 171.26 0.00027307 7919800.0 53804.0 58396.0 61643.0 66951.0 61263.0 47733.0 53319.0 53366.0 46233.0 59955.0 True False 50813.789074477194 62874.78542726527 57676.95649182373 57832.158303082986 53566.594241831095 54307.787472967975 55798.43914959413 53521.286224783114 55480.89185795235 58223.943368202235 0.8727301198604157 1.0798785137181723 0.990605464955896 0.993271066120657 0.920009726979182 0.9327397687499643 0.9583418078835804 0.9192315588506261 0.9528879125739885 1.0 15.829324932598098 -6.244028033858101 23.343244404771664 0.9429972741409909 0.9914242608861503 0.09956039431958208 0.051669700296860875 618.1322025948576 828721.7289370515 0.014459925648671029 0.018611165645332824 5.701274691688098e-07 6.244028033858101 0.04842698674515944 S(ph)IGASPNPFSVHTATAVPSGK ddPTM_A459_Selumetinib_30min_R1 2 SIGASPNPFSVHTATAVPSGK 21 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 1 S(0.63)IGAS(0.369)PNPFSVHTATAVPSGK;S(0.808)IGAS(0.191)PNPFSVHTATAVPSGK 107.19 8.837799999999999e-05 25728000.0 4853.4 5481.4 5124.700000000001 6777.9 9304.3 5758.5 7232.900000000001 5469.799999999999 1374.3200000000002 2970.0 True False 4966.474776927557 4839.635139766275 4428.793887962115 5594.2670019406005 8462.727707807588 5700.574718299663 6687.316529758802 5324.723135585599 2332.120663638626 3351.2284302498515 1.4819863462895249 1.444137646983812 1.3215434221032571 1.6693183166638148 2.5252613732381852 1.701040331015172 1.9954821549601822 1.5888869548616873 0.6959002384283169 1.0 11.710474313178997 -8.18183064036705 4.9583332209120945 0.8516041240173167 1.735866795380984 0.531348479146623 0.32742589010841777 0.17369290984023375 7.396526164696127 0.2610960178020846 0.0918737356156523 6.579143508841209e-09 8.18183064036705 0.8842626713636674 S(ph)IGASPNPFSVHTATAVPSGK ddPTM_A459_Selumetinib_30min_R2 2 SIGASPNPFSVHTATAVPSGK 21 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 1 S(0.5)IGAS(0.5)PNPFSVHTATAVPSGK;S(0.687)IGAS(0.034)PNPFS(0.28)VHTATAVPSGK 107.34 8.763899999999999e-05 17666700.0 67540.0 51925.0 110789.0 148726.0 170962.0 105956.0 77099.0 94092.0 100396.0 131868.0 True False 63786.39718404197 55907.4805348097 103660.95635794282 128469.26223333958 149484.22514032808 120550.47722719687 80684.25626877014 94365.79214223076 120478.00529861757 128060.62820578924 0.49809530124699464 0.43657040667462765 0.8094678107572849 1.0031909419255205 1.1672926115910647 0.9413547232758861 0.6300473252334291 0.7368837203468034 0.9407888043857895 1.0 16.966467466720005 -5.347188955183637 3.965317412706747 0.9053826824749126 0.46477601939081203 0.6117927197945501 0.14063817070510495 0.16528044588939 4.767517700386002 0.042927495878787775 0.09896804238298042 4.495842048154498e-06 5.347188955183637 -0.44060666308410057 S(ph)IGSAVDQGNESIVAK ddPTM_A459_Selumetinib_30min_R1 4 SIGSAVDQGNESIVAK 16 0 Q9H0H5;F8VRD2;F8W1E5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 S(1)IGSAVDQGNESIVAK;S(1)IGSAVDQGNESIVAK;S(1)IGSAVDQGNESIVAK;S(1)IGSAVDQGNESIVAK 245.04 3.1275e-51 72043200.0 8791.3 11287.5 11745.8 11878.0 10469.300000000001 10593.9 10405.3 9219.800000000001 5473.849999999999 8736.6 True False 8996.120185108004 9965.954252583615 10150.784875061063 9803.730277674567 9522.35366350504 10487.33498449159 9620.419843644908 8975.260953868903 9288.723655814001 9858.027711690524 0.9125679545858455 1.0109480865797429 1.0296973362149675 0.994492059101075 0.9659491677237414 1.0638370362922371 0.9758970176393561 0.9104519906375635 0.9422497001909022 1.0 13.267083321206055 -7.528419031517831 24.563405989216243 0.9444453882022701 0.998887317399399 0.17978764038871864 0.042561890006129595 172.42929535750744 764461.8326825436 0.01954045209772045 0.011327260755715343 2.9619721345862594e-08 7.528419031517831 0.05444192919712887 S(ph)IGSAVDQGNESIVAK ddPTM_A459_Selumetinib_30min_R2 2 SIGSAVDQGNESIVAK 16 0 Q9H0H5;F8VRD2;F8W1E5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 S(1)IGSAVDQGNESIVAK;S(1)IGSAVDQGNESIVAK 305.64 1.0735999999999997e-88 44510000.0 82252.0 85719.0 72561.0 110156.0 86979.0 102235.0 105065.0 94093.0 83747.0 88770.0 True False 77680.7631208442 92293.3716699729 67892.50425844337 95152.56277030079 76051.92041787415 116316.943253072 109950.73068234793 94366.7950520653 100498.7400866899 86206.97944784118 0.9010959857124365 1.070602081886122 0.7875522920916301 1.1037686667571047 0.8822014285268948 1.3492752442793636 1.275427249470824 1.0946537699904118 1.165784263993333 1.0 16.395517056371574 -6.7478575923170006 24.99982972083545 1.1890939330741233 0.9554213382778948 0.46222597477681704 0.12251382060692542 205.024579187203 377385.61691658915 0.03929168563039972 0.039086727060484265 1.7870734705578215e-07 6.7478575923170006 -0.23367259479622848 S(ph)IGSDSQGR ddPTM_A459_Selumetinib_30min_R2 1 SIGSDSQGR 9 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 S(1)IGSDSQGR 113.44 0.009110600000000002 14556000.0 30770.0 19721.0 22117.0 28726.0 30208.0 15473.0 27643.0 35819.0 23206.0 35786.0 True False 29059.926582069424 21233.537286990508 20694.01629916886 24813.46924488602 26413.000977053565 17604.26530009077 28928.45427356536 35923.227359845354 27847.84842981512 34752.7651968057 0.8361903410419975 0.6109884254316024 0.5954638769599533 0.7139998530869925 0.7600258807457806 0.5065572538011699 0.8324072662921314 1.033679684376518 0.8013131695308882 1.0 15.084840153846123 -7.505065378123493 10.611590871658562 0.9372142821356108 0.670323629289225 0.5957567728192166 0.10253163032669307 0.3329229921376693 196.58931682046438 0.04271786105144871 0.02747435424291394 3.125608806642851e-08 7.505065378123493 -0.2668906528463858 S(ph)IGVSNFNHR ddPTM_A459_Selumetinib_30min_R1 2 SIGVSNFNHR 10 0 P52895;B4DK69;S4R3P0 P52895 AKR1C2 Aldo-keto reductase family 1 member C2 1 S(1)IGVSNFNHR;S(1)IGVSNFNHR 126.32 0.0022997 9425300.0 4835.200000000001 8473.1 6937.200000000001 9461.400000000001 8662.2 7770.4 9487.0 9202.4 4458.200000000001 7878.9 True False 4947.85075233859 7481.065512962676 5995.166343311962 7809.144102474338 7878.705539435627 7692.236830958703 8771.387951972478 8958.322458392066 7565.239785955035 8890.233561985031 0.556549017282941 0.841492572810684 0.6743542002031888 0.8783958315635855 0.8862203095681608 0.8652457528057523 0.9866318911439244 1.0076588422488904 0.8509607462175438 1.0 13.118005606337071 -3.8109756786043407 0.35628316860225545 0.9784979285189603 3.527691054989188e-17 0.6933966201727642 0.07535197045939396 7.211737912896735 0.4270288984042328 0.064370253971865 3.469099750163415 0.000154534097942911 3.8109756786043407 -0.9784979285189603 S(ph)IGVSNFNHR ddPTM_A459_Selumetinib_30min_R2 2 SIGVSNFNHR 10 0 P52895;B4DK69;S4R3P0 P52895 AKR1C2 Aldo-keto reductase family 1 member C2 1 S(1)IGVSNFNHR;S(0.999)IGVS(0.001)NFNHR 117.7 0.0039297 21622000.0 106241.0 105651.0 124178.0 122851.0 140875.0 83589.0 87904.0 93347.0 82960.0 116283.0 True False 100336.55053641985 113754.0919784918 116188.52267478344 106118.48187020433 123177.02306152089 95102.62600460734 91991.71017847152 93618.62431557217 99554.31809607262 112925.60765048208 0.8885190226026781 1.0073365496564248 1.0288943765031617 0.9397202643235129 1.0907802545793521 0.8421705933959732 0.8146222286728497 0.8290291835783848 0.8815920513282057 1.0 16.785013151346874 -6.786943199194264 24.99991871519008 0.8591182927705097 0.9912057243779083 0.4096222870831243 0.06950990439315657 197.3510115653336 193450.32295611725 0.023445253984225253 0.020684277604777018 1.633265546584789e-07 6.786943199194264 0.13208743160739866 S(ph)IHEVDISNLEAALR ddPTM_A459_Selumetinib_30min_R1 4 SIHEVDISNLEAALR 15 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR 222.09 9.7279e-10 25150200.0 10464.0 10904.3 9761.5 10104.0 11369.500000000002 9823.2 12087.3 10865.9 6200.139999999999 10303.5 True False 10707.790840600393 9627.61948672846 8435.941916081369 8339.52607557029 10341.13073244826 9724.387526751974 11175.545229458941 10577.701034582535 10521.184739691189 11626.05458958901 0.9210167351346423 0.8281071977203578 0.7256065977563576 0.7173135143403019 0.8894789416960606 0.836430575120475 0.9612500219521165 0.9098272292695698 0.9049660534978721 1.0 13.505073967354065 -6.931018879850406 1.6263518124741987 0.9370409802856047 0.8003123145811004 0.4685988020086941 0.06440524876028676 0.3641720724477596 1.9690997735643148 0.03182097860357548 0.02528339847019989 1.1721444084371488e-07 6.931018879850406 -0.13672866570450426 S(ph)IHEVDISNLEAALR ddPTM_A459_Selumetinib_30min_R2 5 SIHEVDISNLEAALR 15 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR;S(1)IHEVDISNLEAALR 191.44 1.8975e-05 21468500.0 27496.800000000003 19607.2 27788.399999999998 27627.3 28621.699999999997 26212.8 28900.0 28117.5 25713.800000000003 23307.100000000002 True False 25968.637934411654 21111.009192915175 26000.5245977223 23864.41408024922 25025.98616475551 29823.375263893213 30243.907264263595 28199.317269897292 30857.278503601643 22634.16346388168 1.1473204201185054 0.9327055195392103 1.148729204824047 1.054353703786345 1.1056731212836988 1.31762657416006 1.336206098914374 1.245874066205105 1.3633054542900136 1.0 14.466214366549982 -6.669244485385083 5.1830701367239636 1.2727672665413365 1.0684962078175024 0.38233321110503027 0.11002766645053677 0.18785309761835112 8.236609717859238 0.03458199340486822 0.03430252466168807 2.14168460376703e-07 6.669244485385083 -0.2042710587238341 S(ph)IKYDSLLEQGLVEAALVSK ddPTM_A459_Selumetinib_30min_R1 1 SIKYDSLLEQGLVEAALVSK 20 1 O96028-3;O96028;O96028-6;D6RIS1;D6R9V2;O96028-7;O96028-5 O96028-3;O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 S(0.998)IKYDS(0.002)LLEQGLVEAALVSK 147.11 1.2294e-05 3453000.0 1539.4 1739.6 1886.6 1764.3 1473.7 1408.2 1778.4 1534.5 909.4 1408.8 True False 1575.2650248490297 1535.9268232819004 1630.4100823520064 1456.1981250127335 1340.4040952028665 1394.0347865432984 1644.2538562019465 1493.8000752415269 1543.1853800519286 1589.6332028740715 0.9909613249150409 0.9662146088197772 1.0256517537531362 0.9160592030789958 0.8432159650285384 0.8769537425507159 1.03436053878915 0.9397136852329975 0.970780792236747 1.0 10.634478196434715 -10.44450913955981 15.335739439223474 0.9999821187740444 0.9498207158958399 0.059100013468914026 0.0576316953086009 0.0 0.0 0.060378133787795864 0.01464384841675041 3.593278347601749e-11 10.44450913955981 -0.050161402878204475 S(ph)ILGTPLSK ddPTM_A459_Selumetinib_30min_R2 1 SILGTPLSK 9 0 Q9NXD2 Q9NXD2 MTMR10 Myotubularin-related protein 10 1 S(0.738)ILGT(0.262)PLSK 98.898 0.019289 3641100.0 49095.0 42863.0 42713.0 52984.0 46017.0 53358.0 43770.0 44295.0 31340.0 42354.0 True False 46366.49644285665 46150.454273732255 39964.89208239814 45767.487797501904 40235.9330628004 60707.58016430194 45805.39172860959 44423.891116568 37608.875712764166 41131.1299710923 1.127284771302025 1.1220322492031614 0.9716458582705164 1.1127213823123294 0.9782355381697255 1.475952160978031 1.1136429210868373 1.0800552075226213 0.9143652445044997 1.0 15.327943086235743 -8.09029632373354 3.8851226628437803 0.9592723410362101 1.128095689832622 0.2090973164795934 0.13130587070162886 0.39627309975561725 10.59541754529669 0.10116592707025744 0.035406958340733756 8.122761024402218e-09 8.09029632373354 0.16882334879641192 S(ph)ILPYPVSPK ddPTM_A459_Selumetinib_30min_R2 1 SILPYPVSPK 10 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 S(0.511)ILPYPVS(0.489)PK 109.79 0.0098548 34127000.0 135980.0 132610.0 118920.0 108590.0 95655.0 75789.0 99679.0 97904.0 69430.0 100970.0 True False 128422.77597106932 142780.76059164372 111268.81667030603 93799.85467180141 83637.96373345003 86228.24680595752 104314.27101019143 98188.88443112036 83317.9400362864 98054.73374843413 1.309705009250715 1.4561332750946747 1.1347623150532793 0.9566071018299954 0.8529722180270126 0.8793889240185156 1.063837175651474 1.0013681204115081 0.8497084929121734 1.0 16.581299660048863 -5.510603763757954 2.911627014523571 0.9421164711202393 1.3818518176440173 0.8466614251171021 0.07444200214142678 0.09385845107813624 1.5968660964638424 0.02164571287926871 0.04764885480996972 3.0860022348738547e-06 5.510603763757954 0.439735346523778 S(ph)ILSPGGSCGPIK ddPTM_A459_Selumetinib_30min_R2 1 SILSPGGSCGPIK 13 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 1 S(0.998)ILS(0.002)PGGSCGPIK 169.58 0.00025018 118820000.0 95184.0 92701.0 104130.0 113100.0 107910.0 70662.0 88592.0 95197.0 76426.0 79284.0 True False 89894.05433174189 99810.86861930472 97430.38916817159 97695.58489161749 94353.38107236005 80395.04909422963 92711.70354171762 95474.00750928836 91713.33552085902 76994.86491542895 1.167533113156071 1.2963314985867802 1.2654141191778048 1.268858449182633 1.2254503099134946 1.0441611811714384 1.2041284005569985 1.2400048706385405 1.1911617173638376 1.0 16.232474609667563 -6.539606538584482 24.99568970621692 1.152895163703749 1.2531541385509164 0.33599164932512227 0.07514616535654858 314.1821518722377 469467.2011737654 0.024599361832954296 0.024604989437354705 2.886645557304131e-07 6.539606538584482 0.10025897484716739 S(ph)INKLDSPDPFK ddPTM_A459_Selumetinib_30min_R2 1 SINKLDSPDPFK 12 1 B1AUU8;P42566;P42566-2 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 S(1)INKLDSPDPFK 83.633 0.018731 4514300.0 52022.0 40126.0 35415.0 39786.0 40783.0 32950.0 42603.0 41951.0 38248.0 39131.0 True False 49130.825500566025 43203.53517457435 33136.43745693651 34367.07816532183 35659.47493535407 37488.56340968082 44584.123916242956 42073.070464638105 45898.66873841115 38001.186355451966 1.2928760971041977 1.1368996423022464 0.8719842887795128 0.9043685595460691 0.9383779390939478 0.9865103436251642 1.1732297907548497 1.1071514997215857 1.2078219955842548 1.0 15.213756838169111 -7.256190821951322 24.522269322217912 1.130980113392571 1.011121863246172 0.12804682068447482 0.1254080320039815 665.6454281121199 3110031.051244431 0.05288977122024431 0.03970468659960115 5.543820729450265e-08 7.256190821951322 -0.11985825014639895 S(ph)IPAGAEPGEK ddPTM_A459_Selumetinib_30min_R1 1 SIPAGAEPGEK 11 0 A6NGP5;Q9H910;Q9H910-3;Q9H910-2;H3BU16 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 S(1)IPAGAEPGEK 128.36 0.0027907 10195000.0 3900.6 3694.3 4317.9 4436.3 4653.6 3544.6 3852.6 3782.0 2402.2 2888.1 True False 3991.476390753622 3261.769638566526 3731.5528965269446 3661.5834846647317 4232.682701659813 3508.944542239296 3561.9952802539465 3681.689074332651 4076.357950253733 3258.815767476294 1.2248241924534196 1.0009064246956556 1.1450640854781275 1.123593276185831 1.2988407457405011 1.0767544999810492 1.0930336460880825 1.1297628761578753 1.250870942425372 1.0 11.670132078327626 -11.91506477497701 2.1451221824443087 0.00018882426427586877 1.1440855195545763 0.22029044568225709 0.08374789164610012 3572861.4079800127 199499.21902109968 17599008.018720366 0.021904460111810083 1.2160046201570703e-12 11.91506477497701 1.1438966952903005 S(ph)IPAGAEPGEK ddPTM_A459_Selumetinib_30min_R2 2 SIPAGAEPGEK 11 0 A6NGP5;Q9H910;Q9H910-3;Q9H910-2;H3BU16 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 S(1)IPAGAEPGEK;S(1)IPAGAEPGEK 114.87 0.0063424 16233300.0 164258.0 126082.0 144498.0 153674.0 162737.0 109337.0 123561.0 163025.0 99910.0 139420.0 True False 155129.19793687234 135752.08398247263 135201.15599752674 132743.33609756338 142292.523172761 124397.1792875348 129306.83133147676 163499.37575975835 119894.79171864285 135394.58234333698 1.145756316478689 1.0026404427189641 0.9985713878468214 0.9804183727303764 1.0509469486152114 0.9187751617127878 0.955036967458397 1.2075769423709475 0.8855213380296904 1.0 17.04681048674135 -4.761237249505131 23.825478599819736 1.0034308765403743 1.145756540998071 0.218848983239479 0.082407644780614 4.184402182966795 490938.7967987995 0.019634366707335666 0.11074927759700164 1.7328571015304018e-05 4.761237249505131 0.14232566445769668 S(ph)IPMPASR ddPTM_A459_Selumetinib_30min_R2 3 SIPMPASR 8 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.99)IPMPAS(0.01)R;S(0.996)IPMPAS(0.004)R;S(1)IPMPASR 90.15 0.02867 57197000.0 94509.0 64860.0 88229.0 97167.0 101677.0 47494.0 73486.0 88529.0 53451.0 60831.0 True False 89256.5681295028 69834.55344222934 82552.44219647188 83932.68697757568 88903.42625608697 54035.86739239396 76903.24460974656 88786.60473323517 64142.69354572297 59074.650972080904 1.5109114765940146 1.1821407709244638 1.3974258135775823 1.4207902306057272 1.5049335847638499 0.9147048099857871 1.3017976973929406 1.5029560610556354 1.085790478491989 1.0 15.85025157996803 -6.708451582885809 24.99999961992078 1.2012744827401973 1.3916089183632214 0.30857983683862944 0.1757628252041863 155.29137971089628 73266.73712300697 0.05859007121900322 0.058590018011902 1.9568089096875554e-07 6.708451582885809 0.1903344356230241 S(ph)IPNGLHDPSSTYIR ddPTM_A459_Selumetinib_30min_R2 1 SIPNGLHDPSSTYIR 15 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(1)IPNGLHDPSSTYIR 81.878 0.03345 0.0 14277.0 14126.0 14227.0 19260.0 14842.0 12056.0 11737.0 14866.0 11264.0 18624.0 True False 13483.541495359284 15209.418777751025 13311.650309186385 16636.754774646826 12977.415270836509 13716.604566528433 12282.79375642428 14909.25759880122 13517.114742456144 18086.276729036745 0.7455122852185511 0.8409369714736783 0.7360083287797482 0.919855148955961 0.717528293150675 0.7583984681881489 0.6791222947896611 0.8243408979176484 0.7473685681672112 1.0 14.142607822477416 -10.860958025825267 3.149664419683793 1.0018211573173748 0.7759824752980419 0.5117039245769033 0.06611359517657114 17130738.074455522 22989204.26805375 293399.41776331613 0.01717825953150634 1.3773425813945615e-11 10.860958025825267 -0.22583868201933288 S(ph)IPQLDLGWPDTIAYR ddPTM_A459_Selumetinib_30min_R1 2 SIPQLDLGWPDTIAYR 16 0 A6ND36 A6ND36 FAM83G Protein FAM83G 1 S(1)IPQLDLGWPDTIAYR;S(1)IPQLDLGWPDTIAYR 164.58 2.3551e-05 99223000.0 2829.5 2472.8 2233.8 1863.6799999999998 2626.3999999999996 1952.1 2443.2 2645.4 1732.04 2124.15 True False 2895.4218447514145 2183.283426426469 1930.4622293850916 1538.223273606376 2388.8425837285804 1932.4636463649858 2258.907456968396 2575.2353985297696 2939.145376803545 2396.80534347314 1.2080337907440344 0.9109139515112801 0.8054313774967289 0.6417806426354933 0.9966777611848023 0.80626641275954 0.9424659633372979 1.0744449504597948 1.226276211711259 1.0 11.22689702994055 -7.7413265315548525 3.187721104889464 1.1223717008946874 0.8842166102258725 0.2799499428821185 0.14696408160813393 0.3054410444974612 6.354682904226107 0.08750960266698471 0.04187408375174411 1.814151150050155e-08 7.7413265315548525 -0.2381550906688149 S(ph)IPQLDLGWPDTIAYR ddPTM_A459_Selumetinib_30min_R2 2 SIPQLDLGWPDTIAYR 16 0 A6ND36 A6ND36 FAM83G Protein FAM83G 1 S(1)IPQLDLGWPDTIAYR;S(1)IPQLDLGWPDTIAYR 133.94 0.00049307 93136000.0 55421.7 47312.9 38928.0 41692.2 48895.0 32488.0 30048.0 31163.6 30845.5 42003.1 True False 52341.58378464339 50941.64729504859 36423.41486160172 36013.65043694342 42752.372973153935 36962.92710329924 31445.291538982434 31254.2809165883 37015.46189527974 40790.36136583999 1.283185096479116 1.2488648197588617 0.8929417058831113 0.8828960869933149 1.0480998829531585 0.9061681697739004 0.7709000481009807 0.7662173089440264 0.9074560914843586 1.0 15.315940667714354 -5.2513941010086365 5.313495434288884 0.8883030219191828 1.2723746232359812 0.7630582757357073 0.0822513203192146 0.08049030392711932 7.858807675786944 0.023347914684818488 0.05863676343907335 5.6053908335772375e-06 5.2513941010086365 0.3840716013167984 S(ph)IPTDNQIK ddPTM_A459_Selumetinib_30min_R2 1 SIPTDNQIK 9 0 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 1 S(0.847)IPT(0.153)DNQIK 93.561 0.024405 3491800.0 37439.0 33751.0 37049.0 38813.0 32349.0 26286.0 36662.0 31997.0 26940.0 33167.0 True False 35358.29026019169 36339.5931734302 34665.30767590119 33526.60244384044 28285.02941627072 29906.657899449783 38366.8556443748 32090.105972611495 32328.75276649226 32209.382531784904 1.0977636788069245 1.1282300471786293 1.0762487496210995 1.0408955344224833 0.8781611813998127 0.9285076443156666 1.1911701693291876 0.9962968380702205 1.0037060702604144 1.0 14.975193383428499 -5.749722905606091 3.0284821328530995 1.002867964099298 1.1091771780090827 0.26085001776439076 0.07611942924555842 0.3745015905120029 7.04793867883901 0.023661970515436965 0.041762025488791286 1.7794143737678832e-06 5.749722905606091 0.10630921390978476 S(ph)IQDLTVTGTEPGQVSSR ddPTM_A459_Selumetinib_30min_R1 2 SIQDLTVTGTEPGQVSSR 18 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 S(1)IQDLTVTGTEPGQVSSR;S(1)IQDLTVTGTEPGQVSSR 267.69 7.432899999999997e-54 93471000.0 3762.4 4466.5 4126.3 4290.9 4274.5 3535.1000000000004 4213.1 4003.8999999999996 2036.1299999999999 3320.2 True False 3850.0565996440114 3943.5601035804825 3565.9711241434766 3541.5748651687004 3887.8722297242716 3499.540103613987 3895.3024750137315 3897.7035654998654 3455.1638969486844 3746.3800114867213 1.0276738045364882 1.0526321653140338 0.951844477391483 0.9453325221440242 1.0377677165166703 0.9341124212931144 1.0397510298128865 1.0403919392985157 0.9222673317588863 1.0 11.871281530447323 -5.2464812677066295 24.858678863273386 0.986134211594836 1.040152990312711 0.21234636234043847 0.04314419226379418 1206.319153849404 2004758.9483219108 0.010848972818692886 0.02842687117970584 5.669160236143163e-06 5.2464812677066295 0.05401877871787486 S(ph)IQDLTVTGTEPGQVSSR ddPTM_A459_Selumetinib_30min_R2 4 SIQDLTVTGTEPGQVSSR 18 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 S(1)IQDLTVTGTEPGQVSSR;S(0.996)IQDLT(0.004)VTGTEPGQVSSR;S(0.999)IQDLT(0.001)VTGTEPGQVSSR;S(1)IQDLTVTGTEPGQVSSR 239.87 5.248300000000001e-25 121927000.0 99755.0 73770.2 95787.0 86045.0 99824.0 67715.9 81954.0 79411.8 64481.6 87774.0 True False 94211.01645090472 79428.13713142055 89624.16870500027 74325.52256409577 87283.2166821172 77043.15056126274 85765.02338877028 79642.87519066881 77379.72176643828 85239.73655576001 1.105247625786315 0.9318205374727105 1.051436481697385 0.8719586142253659 1.0239733275691254 0.9038407868713269 1.0061624642946503 0.9343397622841081 0.9077893115709001 1.0 16.379238513844562 S(ph)IQFVDWCPTGFK ddPTM_A459_Selumetinib_30min_R1 2 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 1 S(1)IQFVDWCPTGFK;S(0.954)IQFVDWCPT(0.046)GFK 138.91 0.00096308 48709000.0 5763.1 6528.1 6317.6 7304.5 6654.0 5458.9 5910.6 5638.2 3580.8 5348.1 True False 5897.36901695949 5763.787017168644 5459.7046200927825 6028.90619744687 6052.146874859112 5403.988422284629 5464.758683348641 5488.656620545308 6076.356068715578 6034.580729905463 0.9772624281474941 0.9551263418525744 0.9047363627163396 0.9990596641734408 1.0029109139043575 0.8955035426909083 0.9055738796014502 0.9095340448998008 1.0069226580403654 1.0 12.559037823679077 -6.758626608172559 24.999247407767307 0.9354818981254613 0.9653449645539847 0.05618461614470016 0.043474305755721435 191.71409912034983 1703913.9707679767 0.015021062262370773 0.014402643231340403 1.7433050644686116e-07 6.758626608172559 0.02986306642852332 S(ph)IQFVDWCPTGFK ddPTM_A459_Selumetinib_30min_R2 2 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 1 S(1)IQFVDWCPTGFK;S(1)IQFVDWCPTGFK 160.63 0.00036391 15597500.0 84745.0 70834.0 83137.0 84926.0 79086.0 59520.0 54736.0 60286.0 49638.0 61198.0 True False 80035.21216111393 76266.74003279179 77788.05593272168 73358.9322944785 69150.50964218946 67718.33973123523 57281.332457326374 60461.422279115446 59566.98700160143 59431.0547285004 1.346690085288571 1.2832809443009559 1.3088789402793166 1.2343535316612668 1.1635416863808081 1.1394436804225287 0.9638283001875934 1.0173371910581444 1.002287226328424 1.0 15.858929364369358 -6.618417497925182 0.9158524451422055 0.987036121990351 1.3209780650165501 0.9488956632278324 0.030790961783985778 0.11284792847900897 0.20684942075721324 0.017393945975787174 0.018716139252763036 2.4075898407520484e-07 6.618417497925182 0.3339419430261992 S(ph)IS(ph)REPSPALGPNLDGSGLLPR ddPTM_A459_Selumetinib_30min_R1 1 SISREPSPALGPNLDGSGLLPR 22 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 2 S(0.896)IS(0.918)REPS(0.186)PALGPNLDGSGLLPR 59.537 0.033462 5848700.0 1468.8 1583.3 1166.9 1522.9 1464.5 1308.4 1436.8 1234.9 776.34 1344.1 True False 1503.0201822127153 1397.9264999437994 1008.4413893228855 1256.954103373515 1332.036233578475 1295.2386839321496 1328.4210192256835 1202.146440479479 1317.3922783698201 1516.6283276427014 0.9910273696053553 0.9217330801915058 0.6649232187890807 0.8287818976236593 0.8782878502928017 0.8540251163219019 0.875904132221011 0.7926440635247647 0.8686322511313275 1.0 10.566651859657416 -8.561045268783275 20.558276556595303 1.0000000026372233 0.8470909954690412 0.23307920398110415 0.0803899459990303 2414.826864508308 1300738.5458233901 0.08047502407360284 0.02077856186179567 2.7476077406629626e-09 8.561045268783275 -0.15290900716818212 S(ph)ISADDDLQESSR ddPTM_A459_Selumetinib_30min_R2 2 SISADDDLQESSR 13 0 P18615;P18615-3;A0A0A0MT02;P18615-4;A2ABK4;A0A0G2JI50;E9PD43;A0A0A0MSN9 P18615 NELFE Negative elongation factor E 1 S(0.934)IS(0.066)ADDDLQESSR;S(0.976)IS(0.023)ADDDLQESSR 259.27 1.2244000000000001e-29 138415000.0 84568.0 59039.0 76957.0 83092.0 95314.0 44866.0 52313.0 74475.0 44876.0 48312.0 True False 79868.04911252667 63567.10145969434 72005.67040444633 71774.72625830492 83339.80320202865 51045.88424700274 54745.658156242964 74691.70991999995 53852.453940204425 46917.10703034919 1.7023225464618388 1.3548810973910816 1.5347423351970133 1.5298199484438826 1.7763201628804346 1.0880015303156432 1.1668592038471113 1.5919930841363312 1.147821282019136 1.0 15.517826437211628 -6.768807034159202 24.9999339903898 1.2339298495781736 1.5618723211540486 0.5206556699789326 0.18068310510863358 163.9187745238668 556205.7850054562 0.0633754126636566 0.05699655194498066 1.7029149799657728e-07 6.768807034159202 0.32794247157587497 S(ph)ISESFLTVK ddPTM_A459_Selumetinib_30min_R2 1 SISESFLTVK 10 0 F5H527;Q76I76;Q76I76-4;J3KSQ9;K7EP00;Q76I76-3 F5H527 SSH2 Protein phosphatase Slingshot homolog 2 1 S(0.997)IS(0.003)ESFLTVK 90.434 0.029443 3725200.0 25263.0 25968.0 29190.0 26551.0 30523.0 20399.0 21408.0 18531.0 15047.0 25659.0 True False 23858.98359580177 27959.66209971957 27311.947179668983 22934.707996970294 26688.427860917833 23208.777086314993 22403.514419147232 18584.9221420278 18056.820448307688 24918.157999911607 0.9574938723755746 1.1220597485503845 1.096066056719195 0.9204014196013867 1.0710433676924476 0.9314001896286764 0.8990838897171575 0.7458385223375551 0.72464507402079 1.0 14.604909804949397 -7.189064817392415 1.7435693110464168 0.8063357866199943 1.0365913291679922 0.4840715817913154 0.0920764533007099 0.28243996274203226 1.6845397047023156 0.04679778782609089 0.030624239383697478 6.470460384983516e-08 7.189064817392415 0.23025554254799796 S(ph)ISGPSVGVMEMR ddPTM_A459_Selumetinib_30min_R1 1 SISGPSVGVMEMR 13 0 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4;C9JIY9;C9JWU7 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 S(0.996)IS(0.004)GPSVGVMEMR 82.705 0.032505 3912200.0 1293.7 1604.1 2043.1 1969.7 1582.4 1365.5 1901.5 1670.8 995.79 1198.4 True False 1323.8406928980055 1416.2912262741418 1765.6582419449724 1625.7288708482572 1439.2721993954108 1351.7643097748005 1758.068324093568 1626.4849564767292 1689.7829003759728 1352.226313404519 0.979008232405235 1.0473773600132996 1.305741667975348 1.2022609342330701 1.064372276391912 0.9996583385302159 1.3001287629636897 1.2028200755698248 1.2496302457845114 1.0 10.401120911062257 -7.266968644833101 24.99419061514074 1.2050464351657566 1.1097731220306406 0.11175112698085754 0.11628165393804034 1036.0352390515297 4683220.054485366 0.04957159229988356 0.03449127487592864 5.407933657030705e-08 7.266968644833101 -0.095273313135116 S(ph)ISGTSTSEKPNSMDTANTSPFK ddPTM_A459_Selumetinib_30min_R1 1 SISGTSTSEKPNSMDTANTSPFK 23 1 Q9UJF2-2;Q9UJF2 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.498)IS(0.147)GT(0.147)S(0.012)T(0.041)S(0.155)EKPNSMDTANTSPFK 101.71 2.1778e-05 29364000.0 1977.8 2336.6 2568.5 2173.9 2159.7 2221.9 2149.8 2176.3 1171.5 1709.1 True False 2023.8788918711252 2063.0297857441305 2219.7118077605905 1794.2691741569918 1964.3555163260037 2199.549703323786 1987.6388551860905 2118.577454381318 1987.9499370253297 1928.4796330437791 1.0494686369473214 1.0697700667380068 1.1510164638125582 0.9304060791790895 1.018603195318999 1.1405615416597212 1.0306766123575486 1.098573932584137 1.0308379217299208 1.0 10.913248194195317 S(ph)ISKDSLASNIVNLTPQNQPHPTATK ddPTM_A459_Selumetinib_30min_R1 1 SISKDSLASNIVNLTPQNQPHPTATK 26 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 S(0.718)IS(0.181)KDS(0.089)LAS(0.011)NIVNLTPQNQPHPTATK 108.07 1.5175000000000002e-08 13615000.0 1295.9 1265.0 1825.3 2055.3 1847.9 1505.3 1687.6 1174.7 198.12 896.62 True False 1326.0919486175508 1116.8932119174547 1577.4342856552098 1696.3804377592649 1680.7577712732427 1490.1580487030446 1560.302973305446 1143.5431400366383 336.195169887715 1011.7099108183908 1.3107432619147228 1.1039658700328232 1.5591764682617315 1.6767458928884382 1.6613040490170219 1.4729103992839492 1.5422434401609135 1.130307341866015 0.3323039206127382 1.0 9.98257996775949 -8.015370797422413 4.390767512874226 0.6687839227021843 1.4746686457938347 0.6841526238562392 0.2189348996684542 0.11536029123664182 5.396249266286453 0.1521988768149995 0.05965641454273461 9.65226423888251e-09 8.015370797422413 0.8058847230916504 S(ph)ISLTRPGSSSLSSGPNSILCR ddPTM_A459_Selumetinib_30min_R2 1 SISLTRPGSSSLSSGPNSILCR 22 1 A0A087WZ32;A0A087X038;A8K727;Q9HB19 A0A087WZ32 PLEKHA2 Pleckstrin homology domain-containing family A member 2 1 S(0.406)IS(0.406)LT(0.131)RPGS(0.017)S(0.017)S(0.017)LS(0.003)S(0.001)GPNS(0.001)ILCR 46.145 0.044735 7770000.0 3933.5 4031.3 5865.5 5117.3 3721.0 5433.4 4162.3 4332.0 4844.9 4436.7 True False 3714.8918170481024 4340.487747327461 5488.120115873529 4420.314912165116 3253.534713837937 6181.801530505603 4355.855197440985 4344.605402798791 5814.015377816564 4308.600943069016 0.8622037329829821 1.0074007327853696 1.2737592059208767 1.0259281308648014 0.7551255632229531 1.434758431376638 1.0109674242280395 1.0083564155059879 1.3493975085274994 1.0 12.073003768787887 -6.7533880537758995 24.999856218928077 1.1518602101253332 1.0044634276340096 0.1815537723267232 0.18383551892896471 394.04226233273664 1223524.5617915199 0.06192386304009656 0.06088637340076142 1.764460523277242e-07 6.7533880537758995 -0.1473967824913236 S(ph)ISLYYTGEK ddPTM_A459_Selumetinib_30min_R2 2 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 1 S(0.989)IS(0.011)LYYTGEK;S(0.981)IS(0.019)LYYTGEK 129.74 0.0028969 8704100.0 46412.0 49298.0 45880.0 48700.0 39864.0 35961.0 33270.0 37741.0 27944.0 45226.0 True False 43832.606841956665 53078.998081946054 42928.13075036702 42066.97598781413 34855.92793131833 40914.30132854423 34817.12092325433 37850.8200616411 33533.58082059611 43920.20786874015 0.9980054505423724 1.2085324878374402 0.9774118300774428 0.9578045740023683 0.7936193752882201 0.9315598289247772 0.7927357954977972 0.8618087640833119 0.7635114323869892 1.0 15.422597262000277 -5.745181177806802 1.9063114452786207 0.8519618878579761 1.1009928533821582 0.5438020511526522 0.0854126244560028 0.22219801611163856 1.6448624252864692 0.02438552847691103 0.05000194575958746 1.7981206234997693e-06 5.745181177806802 0.24903096552418214 S(ph)ISPEWK ddPTM_A459_Selumetinib_30min_R1 1 SISPEWK 7 0 O00159-3;F5H6E2;O00159-2;O00159 O00159-3 MYO1C Unconventional myosin-Ic 1 S(0.575)IS(0.425)PEWK 81.548 0.042821 8542500.0 4727.2 4772.3 5153.2 5318.6 4748.9 4192.1 4163.3 4621.5 2420.8 4395.1 True False 4837.334562470006 4213.556897417923 4453.423744501413 4389.806352486949 4319.362833486393 4149.931280122256 3849.2589291079385 4498.922807252337 4107.9207917634785 4959.2538968993695 0.9754157909709785 0.8496352445379592 0.8980027716035648 0.8851747548621274 0.8709702957912582 0.8368055692242095 0.7761770236274003 0.9071773498156969 0.8283344384387816 1.0 12.275907372973927 -4.755942767041766 24.8351082402513 0.8665981258926323 0.9754159791668314 0.2259396335353423 0.056221540988292955 225.85668517894408 1020360.3655863854 0.013240221091523821 0.11178204371214982 1.7541116500331246e-05 4.755942767041766 0.10881785327419913 S(ph)ISPEWK ddPTM_A459_Selumetinib_30min_R2 1 SISPEWK 7 0 O00159-3;F5H6E2;O00159-2;O00159 O00159-3 MYO1C Unconventional myosin-Ic 1 S(0.914)IS(0.086)PEWK 85.67 0.035913 8147600.0 83067.0 78008.0 69651.0 90095.0 73249.0 63443.0 86382.0 82366.0 58736.0 68488.0 True False 78450.46868354776 83990.96276474588 65169.73049027496 77823.90557745595 64046.80576563161 72181.69737178693 90398.93416268572 82605.67142357476 70484.84122096097 66510.57348680569 1.179518752745542 1.262821208140807 0.9798401528322903 1.1700982490084015 0.9629567512049367 1.085266501064019 1.3591663614300211 1.2419930710710532 1.0597539237117493 1.0 16.021296090154124 S(ph)ISPSALQDLLR ddPTM_A459_Selumetinib_30min_R1 1 SISPSALQDLLR 12 0 Q92793-2;Q92793 Q92793-2 CREBBP CREB-binding protein 1 S(0.867)IS(0.133)PSALQDLLR 219.97 3.4077e-08 11411000.0 1518.9 1841.8 1822.8 1783.4 1500.8 1351.5 1884.1 1510.7 869.19 1104.5 True False 1554.2874147350851 1626.1611997704103 1575.2737719236918 1471.9626685641372 1365.0529049877607 1337.9051370638172 1741.9808201023882 1470.6313285548224 1474.9519468741319 1246.2733337410648 1.2471480955701935 1.3048190599481075 1.2639873848500258 1.1810913615118426 1.0953078012911848 1.0735246441065154 1.3977518197178367 1.1800231046750231 1.183489935106466 1.0 10.283404800846144 -14.522878482516186 0.20957838996842967 1.395404386379482e-09 1.243529147588047 0.34503334268498453 0.09007077564468341 187.88392461765193 1.8672495770007294 79.23686806218471 0.20809791554363274 3.000001815111007e-15 14.522878482516186 1.2435291461926425 S(ph)ITNLTGTNSK ddPTM_A459_Selumetinib_30min_R2 1 SITNLTGTNSK 11 0 Q8IZ41 Q8IZ41 RASEF Ras and EF-hand domain-containing protein 1 S(0.998)IT(0.002)NLTGTNSK 107.93 0.010265 4421400.0 20760.0 13638.0 20023.0 20651.0 21033.0 15605.0 16697.0 17620.0 15127.0 20997.0 True False 19606.242308864526 14683.990746918345 18734.74197939404 17838.298175037988 18390.646502594267 17754.447101914087 17473.443584477824 17671.271282851973 18152.82268369445 20390.76205324232 0.9615257270753621 0.7201295718412571 0.9187857683040855 0.874822536227945 0.9019107012565027 0.87071032733134 0.8569294045437298 0.8666312341201625 0.8902473892979386 1.0 14.315628072995645 -8.804605298598869 2.4471974814171777 0.9999867374135826 0.8686741005502631 0.29795157584750154 0.05873430664094461 1.9317176844220472 15.24682346602598 0.05296668086161549 0.014316075581236284 1.5681756333120054e-09 8.804605298598869 -0.1313126368633195 S(ph)ITST(ph)PLSGK ddPTM_A459_Selumetinib_30min_R2 1 SITSTPLSGK 10 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 2 S(1)ITS(0.008)T(0.985)PLS(0.007)GK 126.12 0.035012 0.0 32510.0 33459.0 28805.0 32633.0 39276.0 49747.0 68398.0 98779.0 113530.0 186990.0 True False 30703.224347841322 36025.19771235815 26951.717660512666 28188.329104935074 34341.79774810499 56599.197691696245 71578.64252806571 99066.43053625619 136239.17229323916 181591.11284163347 0.16907889305473753 0.1983863480355226 0.14841980556624154 0.15522967321378914 0.18911607077409479 0.3116848440763546 0.3941748106940113 0.5455466899564216 0.7502524223861882 1.0 17.470334072588535 -8.058380325082089 0.7432999839071346 1.0025099504557649 0.15845115172418855 0.99385981573923 0.021764102555643226 0.046766645681936975 0.05351186102462439 0.02268428643327784 0.009682051856569172 8.742178603461234e-09 8.058380325082089 -0.8440587987315763 down S(ph)ITSTPLSGK ddPTM_A459_Selumetinib_30min_R1 1 SITSTPLSGK 10 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 S(1)ITSTPLSGK 84.479 0.037812 3553700.0 1677.7 2220.6 2403.4 2304.5 2046.1 2253.2 2213.0 2704.9 1314.6 1848.4 True False 1716.7871457640742 1960.6111196710676 2077.0314809312063 1902.0623358226162 1861.0306162682962 2230.534853741913 2046.0716283034774 2633.1572652465347 2230.780185414851 2085.6601449406808 0.8231384916322991 0.9400434315375146 0.995862861919088 0.9119713681236948 0.89229811519519 1.0694622799177824 0.9810187116375427 1.2625054334158672 1.0695799077458508 1.0 11.02628837677004 -7.0477091611341045 1.6237104954804766 1.1108907196828117 0.9182488844441002 0.4655922218798133 0.08426979305857918 0.319184809963595 1.6876800450644953 0.040971427185617894 0.029622237677721933 8.959645753516884e-08 7.0477091611341045 -0.19264183523871148 S(ph)ITSTPLSGK ddPTM_A459_Selumetinib_30min_R2 3 SITSTPLSGK 10 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 S(0.908)IT(0.081)S(0.011)TPLSGK;S(0.527)IT(0.057)S(0.401)T(0.013)PLS(0.002)GK;S(1)ITSTPLSGK 121.68 0.0047013 60392000.0 100698.0 91772.0 97524.0 98053.0 106719.0 97222.0 98530.0 132165.0 122405.0 144733.0 True False 95101.60828603279 98810.6173065105 91249.41201610277 84698.01224914045 93312.00514003499 110613.448006555 103111.84023349098 132549.5782689063 146889.42028145827 140554.18222850477 0.6766188439090497 0.7030073082127857 0.6492116461376781 0.60260044138312 0.6638863651053356 0.7869808372313399 0.7336091932565747 0.9430496920640536 1.0450732803002194 1.0 17.10076685658307 -7.7254300783672685 1.3189430514575975 1.0385158417025804 0.6659791792737609 0.9100019910795074 0.04511159786307109 0.1262231251229179 0.40475090379324913 0.038369712029889105 0.015261297860029348 1.8817846501175274e-08 7.7254300783672685 -0.37253666242881944 S(ph)ITYS(ph)LENKTYS(ph)S(ph)VR ddPTM_A459_Selumetinib_30min_R2 1 SITYSLENKTYSSVR 15 1 J3KN16;Q5VYK3 J3KN16 KIAA0368;ECM29 Proteasome-associated protein ECM29 homolog 4 S(0.498)IT(0.498)Y(0.119)S(0.883)LENKT(0.004)Y(0.261)S(0.869)S(0.869)VR 72.321 0.035765 0.0 7191.9 8976.9 7790.4 10733.0 10032.0 6580.0 9167.2 7968.3 8023.0 8440.0 True False 6792.202989456785 9665.399364717061 7289.174145546184 9271.146884542279 8771.690472782097 7486.3352727071215 9593.492964462186 7991.48643377692 9627.824181349935 8196.315270246467 0.828689815545924 1.1792371384009022 0.8893233001915745 1.1311359530297194 1.070199252171803 0.9133781493109896 1.17046412298068 0.9750096440027023 1.1746527389325792 1.0 13.00075976316368 -4.73884223835201 24.930751096626917 1.051865969024511 0.8286888835321041 0.30376585831244707 0.1030443369541464 2255.7790897843333 2488601.666498431 0.02342942502001973 1.2627275521833694 1.8245583703303674e-05 4.73884223835201 -0.22317708549240678 S(ph)IYEYYHALDSDHLTK ddPTM_A459_Selumetinib_30min_R1 1 SIYEYYHALDSDHLTK 16 0 A8MYV6;Q16665-2;Q16665;Q16665-3 A8MYV6 HIF1A Hypoxia-inducible factor 1-alpha 1 S(0.989)IY(0.011)EYYHALDSDHLTK 104.41 0.0038822 6929200.0 1993.3 1893.6 2156.4 1617.2 766.68 2044.4 1609.4 1205.7 911.68 1060.5 True False 2039.7400117133757 1671.8964316892432 1863.5727242573246 1334.7863786037476 697.3339293683478 2023.8351921666804 1488.0016622646267 1173.7209193344472 1547.0543735273168 1196.6255051447704 1.704576747648884 1.397175995748957 1.5573566803023018 1.115458740320149 0.5827503478492068 1.691285354912966 1.2434982004537878 0.9808590192070559 1.2928475674936837 1.0 10.224756003021424 -5.76154800900069 24.999994708368693 1.1341037420997497 1.537450504925804 0.3363553993781563 0.2722918412270827 3.562087524755422 820112.3048859375 0.07653304025629545 0.12224440139429449 1.7316175988321306e-06 5.76154800900069 0.4033467628260543 S(ph)IYQVENLK ddPTM_A459_Selumetinib_30min_R1 1 SIYQVENLK 9 0 Q9NY30 Q9NY30 BTG4 Protein BTG4 1 S(0.625)IY(0.375)QVENLK 86.794 0.033374 6572300.0 5961.5 7891.5 7406.4 9681.3 7781.1 7226.2 7337.2 6036.2 3218.8 5020.5 True False 6100.391350940291 6967.559511341184 6400.651560443073 7990.64269550857 7077.300878864783 7153.510988864645 6783.749096786389 5876.100367659108 5462.068508149493 5664.930078811241 1.0768696640683744 1.2299462507758423 1.1298730030903081 1.410545688003508 1.2493183111537929 1.262771276846152 1.1974991751725073 1.037276768805623 0.9641899250582951 1.0 12.467842433898555 -7.791171392360769 2.9843626168266084 0.9853145386351135 1.232036411035841 0.6071961222180897 0.08273413702427636 0.1769652113054608 3.1803407085850965 0.05256201855363738 0.023582867649451802 1.617441595633143e-08 7.791171392360769 0.24672187240072752 S(ph)IYQVENLK ddPTM_A459_Selumetinib_30min_R2 1 SIYQVENLK 9 0 Q9NY30 Q9NY30 BTG4 Protein BTG4 1 S(0.843)IY(0.157)QVENLK 91.867 0.02665 3251700.0 28707.0 29419.0 32238.0 28714.0 28727.0 22143.0 17379.0 19072.0 14439.0 27391.0 True False 27111.579863226114 31675.34270300563 30163.84217808047 24803.10366558716 25118.05743736155 25192.99725585926 18187.157935835196 19127.49636246044 17327.203459368295 26600.150659635183 1.0192265528919355 1.1907956127132722 1.1339726065481677 0.9324422249692376 0.9442825252669467 0.9470997957199081 0.6837238694077619 0.7190747378542393 0.6513949368588251 1.0 14.69914679652753 -6.531040344714742 0.987513230385175 0.7457872175199634 1.1170793843254905 0.5897199502824533 0.11188904290194883 0.3418816883379707 0.7203324168202725 0.05740575102545709 0.06673015445348987 2.9441481181583263e-07 6.531040344714742 0.3712921668055271 S(ph)KDVEFQDGWPR ddPTM_A459_Selumetinib_30min_R1 2 SKDVEFQDGWPR 12 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 S(1)KDVEFQDGWPR;S(1)KDVEFQDGWPR 84.17299999999999 0.018166 14736100.0 5221.4 6356.0 5835.700000000001 5889.9 4743.9 5833.7 5478.1 4986.799999999999 2947.9 4279.7 True False 5343.048460924204 5611.836565175768 5043.2439932055595 4861.3395321161315 4314.81508260357 5775.0182745758 5064.88250655639 4854.533864590708 5002.370993902662 4829.041182808177 1.1064408561985222 1.1621016166013272 1.0443572134277843 1.0066883565671254 0.8935138300258655 1.19589335769912 1.04883812641479 1.0052790359032941 1.0358932145187651 1.0 12.23752105175099 -5.347413919219614 5.461993717881613 1.0291955476033297 1.1337493444179048 0.26307650349082057 0.07085822233590748 0.28834619206139206 13.89005158214093 0.019130618032138027 0.04111282646104206 4.4935138102723806e-06 5.347413919219614 0.1045537968145751 S(ph)KDVEFQDGWPR ddPTM_A459_Selumetinib_30min_R2 1 SKDVEFQDGWPR 12 1 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 S(1)KDVEFQDGWPR 84.821 0.017656 10646000.0 54412.0 48225.0 47150.0 45989.0 42848.0 29358.0 39633.0 43544.0 34174.0 40642.0 True False 51387.99886849407 51923.70243218486 44116.420333038455 39725.21886454996 37465.05117401986 33401.79801461032 41476.01303129962 43670.70583090274 41009.75490134027 39468.5598594025 1.3019983260486772 1.3155712449897055 1.1177610860440024 1.0065028723130955 0.9492378568531594 0.8462887456141396 1.050862083112437 1.1064681859806742 1.0390486769070855 1.0 15.2684162582534 -5.440148460935946 2.438319424444441 0.9975327754347453 1.3162992001203095 0.7792584836852681 0.0651884933796067 0.1489906146251868 1.7091012072261154 0.021005803473319835 0.05417501756167465 3.6295395994979634e-06 5.440148460935946 0.31876642468556426 S(ph)KFDSDEEEEDTENVEAASSGK ddPTM_A459_Selumetinib_30min_R2 4 SKFDSDEEEEDTENVEAASSGK 22 1 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 S(0.802)KFDS(0.198)DEEEEDTENVEAASSGK;S(0.821)KFDS(0.179)DEEEEDTENVEAASSGK;S(0.709)KFDS(0.291)DEEEEDTENVEAASSGK;S(0.5)KFDS(0.5)DEEEEDTENVEAASSGK 160.23 1.968e-09 116815000.0 378203.0 366773.0 381474.0 409392.0 359631.0 316041.0 365966.0 354290.0 291803.0 402735.0 True False 357183.99132656475 394903.3097389271 356930.3781574872 353632.10335940897 314450.9386380679 359572.7790154458 382984.14414787164 355320.9252441327 350171.7536570436 391106.9941188054 0.9132641366624705 1.0097065909769145 0.9126156870747842 0.9041825093314164 0.8040023404504705 0.9193718967506356 0.9792311308846953 0.908500565285718 0.8953349311638058 1.0 18.5772038102783 -10.110873404911484 16.874583204108486 0.9999999990800742 0.9169482384686516 0.19539042522378036 0.050970311289338086 0.0 0.0 0.05277513123666251 0.012799849440858446 7.746875831967568e-11 10.110873404911484 -0.08305176061142261 S(ph)KGIAYVEFVDVSSVPLAIGLTGQR ddPTM_A459_Selumetinib_30min_R1 1 SKGIAYVEFVDVSSVPLAIGLTGQR 25 1 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;A0A0U1RQH7 G3XAC6 RBM39 RNA-binding protein 39 1 S(0.942)KGIAY(0.058)VEFVDVSSVPLAIGLTGQR 97.913 3.1424e-06 1484900.0 366.7 649.86 738.84 729.13 507.22 451.23 497.59 505.45 342.94 592.41 True False 375.2433965260094 573.7740890882827 638.5095861576149 601.8011329652182 461.3420405569642 446.69103588405943 460.05638568799264 492.0438240670119 581.9441326534068 668.451594062059 0.5613621088787049 0.8583629602879121 0.9552069167454714 0.9002912676266982 0.6901652186263366 0.6682473942048655 0.6882418858369587 0.7360949221123864 0.8705853016477048 1.0 9.384679281080476 -11.074370405344489 4.732203258120688 1.001712289607594 0.7730083674512157 0.25726352144334397 0.11721086088328521 0.0022800812489475186 0.00021610127110591464 0.12220631077684824 0.02942775997480457 8.426157927732045e-12 11.074370405344489 -0.22870392215637836 S(ph)KGPSAAGEQEPDKESGASVDEVAR ddPTM_A459_Selumetinib_30min_R1 1 SKGPSAAGEQEPDKESGASVDEVAR 25 2 P50579-3;P50579;G3V1U3;F8VSC4 P50579-3 METAP2 Methionine aminopeptidase 2 1 S(0.993)KGPS(0.006)AAGEQEPDKESGASVDEVAR 60.029 0.0083437 6541100.0 363.0 380.09 468.57 349.72 366.05 360.86 305.26 307.07 180.07 349.51 True False 371.4571937249562 335.5888861009528 404.94076767077263 288.64796705744675 332.9408421313765 357.2300760346647 282.23399243376406 298.9255060960676 305.56563820755525 394.3730130156987 0.9418930339185498 0.8509428257647895 1.0267963433254832 0.731916123900589 0.8442282588898222 0.9058177518359872 0.7156523979051509 0.7579765760599049 0.774813762916865 1.0 8.62341702110384 -5.766827492599635 24.99998595488 0.8089537396407507 0.9309839425735558 0.2695649723283462 0.09013068138305136 166.57070428328888 772865.5553289932 0.024538116531977204 0.03762015392779398 1.7106946902691782e-06 5.766827492599635 0.12203020293280509 S(ph)KPSPQKDQALGDGIAPPQK ddPTM_A459_Selumetinib_30min_R2 1 SKPSPQKDQALGDGIAPPQK 20 2 Q9H9J4-2;Q9H9J4;B4DP25;E5RJP3 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 S(0.868)KPS(0.132)PQKDQALGDGIAPPQK 63.374 0.0080056 19202000.0 101960.0 77127.0 101660.0 104310.0 103550.0 75832.0 91462.0 85103.0 72602.0 100360.0 True False 96293.47137821907 83042.39289760763 95119.30627903894 90102.79805521356 90541.12325125461 86277.16966564246 95715.16422851484 85350.63564043991 87124.42866937161 97462.34603340462 0.9880069103324792 0.8520459056992672 0.9759595387375282 0.9244882944263559 0.9289856743261874 0.8852359211225173 0.9820732634089174 0.8757293366526032 0.8939291143218556 1.0 16.572557329865667 S(ph)KSDATASISLSSNLK ddPTM_A459_Selumetinib_30min_R2 1 SKSDATASISLSSNLK 16 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 S(0.796)KS(0.203)DAT(0.001)ASISLSSNLK 76.34100000000002 0.016204 10853000.0 100570.0 74446.0 79104.0 92201.0 89556.0 70853.0 96760.0 87592.0 81572.0 84628.0 True False 94980.72201360806 80155.76881838121 74014.53476192319 79643.0647444036 78305.17463920193 80612.35761050422 101259.53172630254 87846.8782183638 97888.67931211219 82184.56975004952 1.1557001795163724 0.975314089520228 0.9005891858657397 0.9690756426251853 0.9527965514372575 0.9808697405811466 1.2320990671882361 1.068897464396726 1.191083430987399 1.0 16.326579931184746 -7.229711416357815 23.567742359048037 1.1287614356785711 0.9818550236257209 0.3699282730216574 0.08520777019672489 322.1737071485705 239312.78933772608 0.03179033310301443 0.02462145808398588 5.89235065158849e-08 7.229711416357815 -0.14690641205285027 S(ph)KSDSYTLDPDTLR ddPTM_A459_Selumetinib_30min_R1 1 SKSDSYTLDPDTLR 14 1 A0A499FJI4;O75592-2;O75592 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 S(0.956)KS(0.04)DS(0.004)YTLDPDTLR 71.529 0.029960000000000007 21483000.0 4640.0 6118.4 6166.2 7513.1 6285.5 6286.0 6127.5 5759.9 3125.1 4904.0 True False 4748.102972131672 5402.054883633008 5328.863908512108 6201.078123353832 5716.977634795159 6222.768547231346 5665.297741721451 5607.128741207992 5303.066451726722 5533.476169005142 0.8580687486696682 0.9762497783747098 0.963022835150328 1.120647841240946 1.0331620594695736 1.1245676961775244 1.0238225608442457 1.0133103622304191 0.9583607645101967 1.0 12.43397036118165 -4.770511870033504 1.3546731414749 1.0395477772138615 0.7836518131824485 0.5060327346444115 0.052227256036502905 1.1088937389357694 1.7765408626588706 0.015763591271883294 0.39633400990801887 1.696243240309632e-05 4.770511870033504 -0.255895964031413 S(ph)KSEEAHAEDSVMDHHFR ddPTM_A459_Selumetinib_30min_R2 3 SKSEEAHAEDSVMDHHFR 18 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 S(0.666)KS(0.334)EEAHAEDSVMDHHFR;S(0.763)KS(0.237)EEAHAEDSVMDHHFR;S(0.5)KS(0.5)EEAHAEDSVMDHHFR 118.19 0.00042935 28979100.0 169778.0 188041.0 182791.0 150703.0 160684.0 87252.0 127455.0 123356.0 105250.0 128139.0 True False 160342.41843518327 202463.14005288694 171030.4260677932 130176.99142282446 140497.43938681402 99270.17100520407 133381.9100472911 123714.94553731476 126302.94093070911 124439.29412489467 1.2885191897203634 1.6270032828190337 1.3744085199980072 1.046108404409391 1.1290440079626491 0.7977397469449692 1.0718632806886632 0.9941791008003235 1.0149763530797915 1.0 16.925082590836062 -5.735362540703055 3.1971843625070178 1.000478311213008 1.4691152079597232 0.7581922623801329 0.11007466921465953 0.10597514421424838 2.226698966959529 0.03032113887749339 0.05359369561320066 1.8392360015118232e-06 5.735362540703055 0.46863689674671516 S(ph)KSISSSNPDLAVAPGSVDDEVSR ddPTM_A459_Selumetinib_30min_R2 3 SKSISSSNPDLAVAPGSVDDEVSR 24 1 K7ESB7;K7EKT0;K7EP20;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 S(0.2)KS(0.2)IS(0.2)S(0.2)S(0.2)NPDLAVAPGSVDDEVSR;S(0.402)KS(0.15)IS(0.15)S(0.15)S(0.15)NPDLAVAPGSVDDEVSR;S(0.305)KS(0.174)IS(0.174)S(0.174)S(0.174)NPDLAVAPGSVDDEVSR 111.01 6.2423e-06 13634200.0 62173.0 48142.0 62446.0 61102.0 58932.0 37786.0 42127.0 52012.0 36682.0 47542.0 True False 58717.67355823863 51834.336599071896 58428.29234606403 52779.802193170835 51528.435301235506 42990.67851284366 44085.98897306689 52163.34630894985 44019.42498071522 46169.338931049475 1.2717893501990396 1.1227004284484705 1.2655215278980365 1.1431786422585257 1.1160747910683635 0.9311521349059619 0.9548758980263088 1.1298265800784366 0.9534341621493652 1.0 15.494647455065937 -6.411485862188891 2.3339438016286294 1.0007465340602182 1.204749062187479 0.6735432060460106 0.06766426103396735 0.18662209208091837 1.9976100370963072 0.023091824805865406 0.026651435982618786 3.87716369834875e-07 6.411485862188891 0.20400252812726083 S(ph)KSLCHDEIENLLDSDHR ddPTM_A459_Selumetinib_30min_R1 1 SKSLCHDEIENLLDSDHR 18 1 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 S(0.5)KS(0.5)LCHDEIENLLDSDHR 98.443 0.0014005 6394600.0 3865.0 4123.8 3731.9 3759.3 5400.2 4126.4 4808.1 3889.0 1075.3 2486.9 True False 3955.0469800191627 3640.9835788973924 3225.1284778593526 3102.808825800811 4911.752863482748 4084.892162471432 4445.421145976481 3785.851086747667 1824.7055631953374 2806.11783945736 1.409437239023426 1.297516279502174 1.1493204000595427 1.1057300524488396 1.7503729866285909 1.455709416416154 1.584189047041633 1.3491418761942533 0.6502597779529439 1.0 11.454359879090712 -8.223590383813004 9.457736277582443 0.8255768412304657 1.3885748314553226 0.5697826201885611 0.19553184442923482 0.32242537549986156 79.3677672791949 0.14220439922338765 0.05297420437589539 5.975986616517306e-09 8.223590383813004 0.5629979902248569 S(ph)KSMSDVSAEDVQNLR ddPTM_A459_Selumetinib_30min_R2 1 SKSMSDVSAEDVQNLR 16 1 E9PMS6;E9PJ10 E9PMS6 LMO7 1 S(0.495)KS(0.495)MS(0.01)DVS(0.001)AEDVQNLR 57.794 0.045522 5880800.0 39910.0 34273.0 34606.0 37048.0 35414.0 22874.0 25588.0 30126.0 18314.0 29627.0 True False 37691.961972388424 36901.628894935646 32379.487636163914 32001.998488635276 30964.976714823064 26024.68587050195 26777.89270166011 30213.66167237222 21977.31173591459 28771.591529809488 1.3100409107830122 1.282571694259695 1.125397863465995 1.1122776595614756 1.076234405828439 0.9045271563631946 0.9307059942762026 1.0501213198814061 0.7638545720748356 1.0 14.812357406975522 -5.61807718295297 0.6264440926235387 0.9185964069786581 1.395797162243048 0.768320947452489 0.07632154764672339 0.6869518730640618 0.4014476638359484 0.04251261710190522 0.20695427673828834 2.4094771775855984e-06 5.61807718295297 0.47720075526439 S(ph)KSPASVNGTPSSQLSTPK ddPTM_A459_Selumetinib_30min_R2 2 SKSPASVNGTPSSQLSTPK 19 1 G5E9L9;Q8N568-2;Q8N568 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 S(0.491)KS(0.491)PAS(0.018)VNGT(0.001)PSSQLSTPK;S(0.746)KS(0.248)PAS(0.006)VNGTPSSQLSTPK 90.694 0.0014498 11457100.0 73227.0 60413.0 70334.0 76191.0 83555.0 66178.0 72487.0 71870.0 55812.0 73924.0 True False 69157.33649090663 65046.48284158802 65808.78701386898 65813.65436319388 73058.07390882258 75293.41879592888 75857.78913026555 72079.12980128097 66975.95951757485 71789.62204238138 0.9633333415528951 0.9060708357426298 0.9166894203039322 0.9167572204843264 1.0176690144111966 1.048806452156539 1.0566678995117498 1.004032724378026 0.9329476547186061 1.0 16.131487681673867 -6.262881170379526 24.76996340577718 1.014493918645571 0.9236651905626162 0.5868171568778433 0.034517944342622765 81.43300475075334 1399019.506662873 0.011183315793398381 0.013369136161692061 5.459072092301345e-07 6.262881170379526 -0.09082872808295483 S(ph)KSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSK ddPTM_A459_Selumetinib_30min_R1 1 SKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSK 36 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.421)KS(0.421)PLPPEEEAKDEEEDQT(0.158)LVNLDTYTSDLHFQVSK 53.094 0.00093327 11304000.0 1964.3 2035.9 2718.1 2426.1 1776.5 1852.2 2313.6 2102.4 1018.2 2006.8 True False 2010.0643681375527 1797.535881535767 2348.9969494545685 2002.4271785373196 1615.8158886665497 1833.5685496630429 2139.0832893099537 2046.6375224423505 1727.8110336143325 2264.3923278873413 0.8876837919747439 0.7938270499321346 1.0373630578611626 0.8843110594733233 0.7135759421045611 0.8097397818750546 0.944661074393279 0.903835213199051 0.7630351915325404 1.0 11.144908225367804 -10.20284914565528 11.188581671472848 0.9999999998205994 0.8618062113951082 0.18139680384845502 0.08926796491165347 0.0 0.0 0.08934423113508892 0.0216691589417394 6.26831559916169e-11 10.20284914565528 -0.13819378842549124 S(ph)KSPPKVPIVIQDDSLPAGPPPQIR ddPTM_A459_Selumetinib_30min_R1 3 SKSPPKVPIVIQDDSLPAGPPPQIR 25 2 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 S(0.5)KS(0.5)PPKVPIVIQDDSLPAGPPPQIR;S(0.5)KS(0.5)PPKVPIVIQDDSLPAGPPPQIR;S(0.5)KS(0.5)PPKVPIVIQDDSLPAGPPPQIR 99.414 1.7585e-06 387794000.0 9524.8 11122.0 10300.7 11094.8 8804.699999999999 9938.9 9280.699999999999 8552.6 5756.85 8866.5 True False 9746.709307965459 9819.831069522479 8901.92151769496 9157.301455189745 8008.316439596038 9838.923689799172 8580.649327065566 8325.757265239938 9768.953986311792 10004.601642023672 0.9742226284178119 0.9815314413194548 0.889782705620484 0.9153089531046495 0.8004632994039095 0.9834398251771884 0.8576702635538344 0.8321927811966187 0.9764460731027952 1.0 13.288376103462916 -5.259242037773878 24.662586632453277 0.8983923856648064 0.9778770439402618 0.15859138246243953 0.06298201652935465 236.42859418181433 2653580.017428109 0.015374740663874039 0.036793589027080624 5.5050080987630735e-06 5.259242037773878 0.07948465827545537 S(ph)KSPPKVPIVIQDDSLPAGPPPQIR ddPTM_A459_Selumetinib_30min_R2 2 SKSPPKVPIVIQDDSLPAGPPPQIR 25 2 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 S(0.5)KS(0.5)PPKVPIVIQDDSLPAGPPPQIR;S(0.5)KS(0.5)PPKVPIVIQDDSLPAGPPPQIR 89.816 2.1192e-05 35666300.0 198996.0 165794.0 194306.0 195159.0 176293.0 145097.0 164968.0 168143.0 139457.0 168791.0 True False 187936.5989641044 178509.8666882662 181804.56350437706 168578.00753194728 154145.49726058336 165082.79469057536 172639.33887789043 168632.26829242785 167352.29675414678 163917.56525831454 1.1465311766188007 1.0890221948267467 1.1091219126996839 1.0284316221162049 0.9403842536196071 1.0071086306731347 1.0532082916545973 1.0287626468016622 1.020954017285576 1.0 17.322610935056233 -5.795417214157174 4.2963882103354925 1.0098945647842403 1.1136180307328964 0.7165843562560168 0.030057354174409447 0.11920946135583675 4.853162269997733 0.009242665464271374 0.014853203330200203 1.6017059387506565e-06 5.795417214157174 0.10372346594865611 S(ph)KSPRDPDANWDSPSR ddPTM_A459_Selumetinib_30min_R1 1 SKSPRDPDANWDSPSR 16 2 Q9UHB7;Q9UHB7-2;Q9UHB7-3 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 S(0.5)KS(0.5)PRDPDANWDSPSR 75.02 0.035613 12454000.0 1751.2 1619.0 1640.2 1985.9 1532.7 1329.2 1555.3 1486.2 937.15 1353.9 True False 1791.9995527579713 1429.4467273473206 1417.4698489736884 1639.0998449599201 1394.067555620164 1315.8294548170375 1437.9824688207866 1446.7811481420367 1590.2751032721194 1527.6862531027862 1.1730154337111793 0.9356939125714213 0.9278540316080973 1.0729296291243369 0.9125352491643898 0.8613217878635355 0.9412812780766942 0.9470407586659707 1.0409697017579447 1.0 10.57713256653715 -4.758228664512918 24.952224206431232 0.9556825468454159 1.1730157408304294 0.5361209557284097 0.059335076258571415 70.5722090685284 548361.573146988 0.015187013873826184 0.1058167525334652 1.7449031854640265e-05 4.758228664512918 0.2173331939850135 S(ph)KSPTISDK ddPTM_A459_Selumetinib_30min_R2 1 SKSPTISDK 9 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 S(0.687)KS(0.296)PT(0.016)ISDK 113.38 0.04343 9832400.0 14736.0 12721.0 10065.0 13031.0 10289.0 8293.8 16027.0 23281.0 10899.0 20098.0 True False 13917.03211288188 13696.659795538073 9417.42885794342 11256.155320271168 8996.403835172938 9436.195666379692 16772.287256898027 23348.74385562297 13079.10454350405 19517.718519124817 0.7130460509124058 0.7017551658057336 0.48250664383316977 0.5767147071642418 0.4609352177283239 0.48346817058220465 0.8593364660148867 1.1962844854404602 0.6701144158159794 1.0 14.252496801635072 -7.391385593947307 4.7914148250706745 0.9627602774942691 0.5683827321085101 0.6046632837281045 0.1443701936925713 0.15162979510883712 5.246852621977368 0.06191770865898838 0.04072479497151317 4.060826233747838e-08 7.391385593947307 -0.394377545385759 S(ph)KSPVGNPQLIQFSR ddPTM_A459_Selumetinib_30min_R1 1 SKSPVGNPQLIQFSR 15 1 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;G8JLP4 Q9Y4F3-3 KIAA0430 Meiosis arrest female protein 1 1 S(0.982)KS(0.018)PVGNPQLIQFSR 115.04 0.0013312 47806000.0 1202.8 1211.9 1207.8 1607.1 1528.9 918.04 1046.9 1233.3 736.35 1271.3 True False 1230.822899758615 1070.0101846029747 1043.7873939705046 1326.4501540032659 1390.6112649492184 908.8053511136272 967.931490135975 1200.5888776770112 1249.5321691238598 1434.4837385106512 0.858024993044894 0.7459200518466036 0.7276397535563659 0.9246881776299878 0.969415844611119 0.6335417591120217 0.6747594721017383 0.8369484055103471 0.8710675036450278 1.0 10.48631589828765 -8.566275402506294 2.0767113361498892 0.9981780529009261 0.7924160873375162 0.2834419949879493 0.1000619611222548 0.5142756638559518 5.088781684346648 0.1034337210712435 0.02870594078733732 2.7147172183401148e-09 8.566275402506294 -0.20576196556340987 S(ph)KSPVGNPQLIQFSR ddPTM_A459_Selumetinib_30min_R2 1 SKSPVGNPQLIQFSR 15 1 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;G8JLP4 Q9Y4F3-3 KIAA0430 Meiosis arrest female protein 1 1 S(0.947)KS(0.053)PVGNPQLIQFSR 85.28 0.011483 44389000.0 39686.0 43267.0 42401.0 56918.0 52250.0 44060.0 34180.0 35100.0 21538.0 36662.0 True False 37480.410995645354 46585.439774667546 39672.9658227182 49165.67021097339 45685.887879073416 50128.86506314227 35769.43772638512 35202.13518888221 25846.201822001134 35603.47280068435 1.0527178403485664 1.308452128685944 1.1143004516670527 1.3809234421095111 1.2831862817100042 1.4079768382082862 1.0046614813849726 0.9887275712105695 0.7259460886496536 1.0 15.119730349616617 -7.4611371038586825 3.914314749958156 0.9043810913712673 1.2599977134899767 0.6316862807374071 0.12400167855289858 0.14666008695561572 4.454083116579003 0.05629719521430689 0.0350765655612317 3.458301843186593e-08 7.4611371038586825 0.35561662211870937 S(ph)KSQSSGSSATHPISVPGAR ddPTM_A459_Selumetinib_30min_R1 1 SKSQSSGSSATHPISVPGAR 20 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.592)KS(0.376)QS(0.022)S(0.007)GS(0.001)S(0.002)ATHPISVPGAR 111.88 0.00018743 19997000.0 2451.7 2586.7 2822.1 3193.3 2242.6 2586.9 2902.5 2128.7 960.34 1718.3 True False 2508.8198398222457 2283.8479614757957 2438.8743206856775 2635.650100664945 2039.7572259631875 2560.8781347172717 2683.5620881838454 2072.2399610079106 1629.6268395415316 1938.8605426593663 1.2939661128907787 1.1779330752397696 1.2578905326220553 1.359380957358518 1.0520391648000789 1.3208160558080873 1.3840923723699265 1.0687926828226642 0.8405075061800548 1.0 10.92099332242898 -7.977469400841235 5.432521971052679 0.9281804453031786 1.2572627972269435 0.676370193838848 0.09669656346437365 0.0956708402052737 8.305301225879667 0.05706410249080238 0.025272451806007644 1.0532478933780418e-08 7.977469400841235 0.3290823519237649 S(ph)KSQSSGSSATHPISVPGAR ddPTM_A459_Selumetinib_30min_R2 1 SKSQSSGSSATHPISVPGAR 20 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.731)KS(0.198)QS(0.028)S(0.036)GS(0.004)S(0.002)AT(0.001)HPISVPGAR 58.345 0.01966 8166600.0 24082.0 25831.0 30044.0 27225.0 32030.0 23529.0 18757.0 23593.0 24199.0 27279.0 True False 22743.61884788417 27812.154640244 28111.00174943387 23516.90803425544 28006.105048166894 26769.90617500394 19629.237666290395 23661.65172396859 29039.47617655331 26491.384390646148 0.8585288904688092 1.0498565960208635 1.0611375130459242 0.8877191047274613 1.0571778596084083 1.0105136741912264 0.7409668508385424 0.8931829071312442 1.0961856786467856 1.0 14.693235617795775 S(ph)KSQSSSNCSNPISVPLRR ddPTM_A459_Selumetinib_30min_R1 1 SKSQSSSNCSNPISVPLRR 19 2 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.431)KS(0.431)QS(0.048)S(0.02)S(0.013)NCS(0.058)NPISVPLRR 65.189 0.027567 38353000.0 1851.4 2505.0 3223.4 3550.0 3276.2 2399.4 2681.2 2445.4 1587.8 1836.5 True False 1894.53401780271 2211.7134354570953 2785.6799848687915 2930.0591417532173 2979.8682884600908 2375.2642144808915 2478.954925353495 2380.54004822133 2694.3806316763275 2072.232664024866 0.9142477341916738 1.0673094164828567 1.3442891974582658 1.4139624341516785 1.4379988985755767 1.1462343276972826 1.1962724883115483 1.1487802936170513 1.3002307503651993 1.0 11.016970278222527 -10.551861190868449 14.599468695631717 1.0000169114747588 1.2253771670249312 0.15361994548320168 0.15338846892899285 0.0 0.0 0.161412941159275 0.039148388573017605 2.8063304535064043e-11 10.551861190868449 0.22536025555017236 S(ph)KSTAALSGEAASCSPIIMPYK ddPTM_A459_Selumetinib_30min_R2 2 SKSTAALSGEAASCSPIIMPYK 22 1 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 S(0.436)KS(0.436)T(0.128)AALSGEAASCSPIIMPYK;S(0.333)KS(0.333)T(0.333)AALSGEAASCSPIIMPYK 138.12 6.9042e-06 37084000.0 346130.0 194975.0 287160.0 374030.0 315380.0 285240.0 259810.0 336160.0 215430.0 201341.0 True False 326893.4802681733 209928.95555656328 268684.4382361684 323086.4687622606 275759.1448670273 324529.2208490855 271891.67980374803 337138.16994571604 258522.01961712836 195527.76218325764 1.6718520000335997 1.0736529340514223 1.37414981502394 1.6523815603200587 1.4103324345755726 1.6597603185624439 1.3905528134102951 1.7242470643618095 1.3221755147733425 1.0 17.577013938851998 -8.535777480590578 23.249015662008905 0.9999999917537471 1.4836887357294835 0.3975534592006307 0.18625675171928024 832.6166945222707 1500730.73065644 0.17752499654511872 0.04583675704604788 2.9122088639628487e-09 8.535777480590578 0.48368874397573636 S(ph)KSYNTPLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R1 2 SKSYNTPLLNPVQEHEAEGAAAGGTSIR 28 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.427)KS(0.314)Y(0.014)NT(0.245)PLLNPVQEHEAEGAAAGGTSIR;S(0.257)KS(0.257)Y(0.229)NT(0.257)PLLNPVQEHEAEGAAAGGTSIR 97.957 5.499e-07 18627200.0 1639.3799999999999 1647.18 1817.2399999999998 2321.04 1886.32 1652.74 1715.41 1674.28 729.36 1370.77 True False 1677.5743643218138 1454.3273998467932 1570.4687893847981 1915.7139353168689 1715.702689056844 1636.1149361678547 1586.0152426154868 1629.8726555720975 1237.6706496532604 1546.7216819305022 1.0846000181674516 0.9402644424248393 1.015353187151716 1.2385640918447707 1.1092510754200022 1.0577953068620456 1.0254044157678979 1.0537594931350627 0.8001896295321164 1.0 10.594997905352011 -8.156692978502228 7.523668249038387 0.9011337234003187 1.0661063003753855 0.37855306088571417 0.08491754517666582 0.27522745167797746 17.07916307808268 0.06045030021015941 0.022609610602708705 6.97119163551964e-09 8.156692978502228 0.16497257697506673 S(ph)KSYNTPLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R2 1 SKSYNTPLLNPVQEHEAEGAAAGGTSIR 28 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.417)KS(0.417)Y(0.076)NT(0.089)PLLNPVQEHEAEGAAAGGTSIR 83.934 1.6719e-05 4577200.0 16648.0 16840.0 18560.0 18482.0 20377.0 14230.0 13955.0 15991.0 14698.0 16836.0 True False 15722.77080722431 18131.57385086559 17365.86980660008 15964.719716771684 17817.05908730869 16190.05333292133 14603.935151307916 16037.531162547437 17638.010696432928 16349.90093481866 0.9616431848673275 1.1089714808150726 1.0621391454193962 0.9764413729732946 1.089734987284576 0.9902233290259932 0.8932124548967423 0.9808946993919699 1.0787839490128726 1.0 13.996994273910188 -6.943115478192078 12.501667282799923 0.9802214877951321 1.0412487193614197 0.15000808661147935 0.05965529739068526 1.526400548763667 332.40753615294574 0.021180491317199315 0.01867911311583731 1.1399466373138744e-07 6.943115478192078 0.06102723156628764 S(ph)KTFNPGAGLPTDK ddPTM_A459_Selumetinib_30min_R2 1 SKTFNPGAGLPTDK 14 1 P09661;H0YLR3;H0YMA0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 S(0.963)KT(0.037)FNPGAGLPTDK 84.208 0.014407 11633000.0 115950.0 166150.0 111410.0 148980.0 138560.0 103140.0 129440.0 117030.0 101170.0 153120.0 True False 109505.96318462625 178893.1707435458 104242.0018940365 128688.66699516549 121152.85405788351 117346.59878829998 135459.21648049421 117370.5379246404 121406.8269259845 148699.02774646188 0.7364268942722244 1.2030554163983251 0.7010267886335714 0.8654304533489291 0.8147521600776989 0.7891551180037363 0.9109623548545179 0.7893161085408179 0.8164601259733066 1.0 17.18203568894252 -5.295041166962217 24.986876282814602 0.8296759316189122 0.9697417358588468 0.14591610670744626 0.12883561289772852 901.9040753584021 670670.0124870122 0.03061357900089393 0.06373249130467265 5.0694265268331535e-06 5.295041166962217 0.14006580423993464 S(ph)KTPPPPPQTAQTK ddPTM_A459_Selumetinib_30min_R2 1 SKTPPPPPQTAQTK 14 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.5)KT(0.5)PPPPPQTAQTK 161.48 0.00015557 42928000.0 185060.0 180310.0 191100.0 190740.0 180290.0 146770.0 170500.0 169160.0 125460.0 179230.0 True False 174775.106053876 194139.19721197014 178804.83405394803 164760.88295514733 157640.3583869503 166986.23525459343 178428.58783934044 169652.2275940546 150555.50564529045 174055.16420453458 1.004136285485304 1.1153888946600548 1.0272883017928274 0.9466015197431005 0.9056919345507324 0.9593868473696399 1.025126652546009 0.974703786408164 0.8649872948806657 1.0 17.40918509379427 -5.6360825717033185 4.192991468469985 0.9540696948905647 1.0622297446713094 0.4460770886106261 0.0492838311794153 0.1903108119969706 5.960861549703674 0.013797152123591162 0.02489640175887283 2.3116252428449216e-06 5.6360825717033185 0.10816004978074467 S(ph)KTPTGPELDTSYK ddPTM_A459_Selumetinib_30min_R1 3 SKTPTGPELDTSYK 14 1 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2;A0A5F9ZHE1;A0A5F9ZH87;H0Y325;F8WAI0;Q5JV20;Q8NF91-9;H0Y326;Q8NF91-3;Q8NF91-11;Q8NF91-8;A0A5F9ZH86 Q8NF91 SYNE1 Nesprin-1 1 S(0.621)KT(0.349)PT(0.03)GPELDTSYK;S(0.996)KT(0.004)PTGPELDTSYK;S(0.693)KT(0.26)PT(0.047)GPELDTSYK 124.47 0.00081247 90486000.0 4582.12 5695.02 5333.81 5666.68 5405.870000000001 5487.08 5314.45 5584.42 3139.88 4278.8 True False 4688.8744807465455 5028.244410857034 4609.507898521126 4677.100714757781 4916.910012983868 5431.884957070023 4913.576757811757 5436.3030408473705 5328.147032238234 4828.025659041437 0.9711784509607351 1.0414701093066163 0.9547397267636526 0.9687398214214087 1.0184100831726064 1.1250737549204486 1.017719686019089 1.1259888461170071 1.1035871406897393 1.0 12.237217628127322 -6.566151588722503 6.384491107754402 1.0785834871682098 0.9868276852178989 0.48354501947808326 0.04417735279578355 0.1584698432639205 16.263020574795778 0.014125496080021522 0.014221924169284727 2.7154912722176697e-07 6.566151588722503 -0.09175580195031097 S(ph)KTPVQAAAVSIVEKPVTR ddPTM_A459_Selumetinib_30min_R2 1 SKTPVQAAAVSIVEKPVTR 19 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 S(0.5)KT(0.5)PVQAAAVSIVEKPVTR 53.519 0.025551 4054600.0 13720.0 18075.0 11769.0 15104.0 16090.0 11577.0 13769.0 12087.0 7230.4 11128.0 True False 12957.497325511624 19461.29437971469 11011.795353118343 13046.8091441467 14068.63035357494 13171.62666445751 14409.285782755896 12122.171168889436 8676.682034255586 10806.705725983731 1.1990237963412396 1.8008535508579453 1.0189779968414883 1.2072882777567309 1.3018426438454977 1.2188382841579135 1.3333652408161807 1.1217267756021883 0.8028979648620671 1.0 13.399639184111372 -8.012132363758031 3.672831675868308 0.9064906588916769 1.2984307297000706 0.3973129950031269 0.19426472972121941 0.23266435237712355 6.661166137059955 0.13574607761046117 0.05145311172333105 9.724507962044596e-09 8.012132363758031 0.39194007080839366 S(ph)LAIPDDDRFEDLEEANPFSFR ddPTM_A459_Selumetinib_30min_R1 1 SLAIPDDDRFEDLEEANPFSFR 22 1 Q96C92-4 Q96C92-4 SDCCAG3 Serologically defined colon cancer antigen 3 1 S(1)LAIPDDDRFEDLEEANPFSFR 89.62200000000001 0.00024317 2630000.0 180.2 247.11 266.72 136.66 273.13 273.97 305.27 338.67 47.103 261.64 True False 184.39830939183776 218.17824632167765 230.50088898808826 112.794896425914 248.42543972501807 271.2141105448571 282.2432381257128 329.68737144480133 79.93035073299536 295.2240425894178 0.6246046486406572 0.739026010239649 0.7807659801903629 0.38206541525746684 0.8414810580671954 0.9186721656069438 0.9560306662362251 1.1167361863658012 0.2707447199487012 1.0 8.205666406810204 -6.4874606844022376 24.662579018495737 0.8677484846584607 0.6451702400888591 0.17259361574079102 0.23305106770453057 907.7429409635515 632086.8739401578 0.07053178057671945 0.0799385056968042 3.2549124807634537e-07 6.4874606844022376 -0.2225782445696015 S(ph)LAS(ph)SHSRSRSPS(ph)S(ph)RSHSR ddPTM_A459_Selumetinib_30min_R2 1 SLASSHSRSRSPSSRSHSR 19 3 P30414;A0A087WYW3 P30414 NKTR NK-tumor recognition protein;Putative peptidyl-prolyl cis-trans isomerase 4 S(0.92)LAS(0.634)S(0.446)HSRSRS(0.01)PS(0.652)S(0.652)RS(0.551)HS(0.134)R 77.13 0.013374 3344000.0 18778.0 17865.0 18380.0 22287.0 22097.0 16264.0 16719.0 17574.0 13638.0 16189.0 True False 17734.393934289885 19235.188054971124 17197.4508106309 19251.47215278057 19320.97731031358 18504.218370107694 17496.466628070004 17625.137430467676 16365.981077558334 15721.581505926546 1.128028622795014 1.2234893829046434 1.0938753715170448 1.2245251627848868 1.2289461656914207 1.176994716665889 1.1128948205035467 1.1210791626671621 1.0409882155550871 1.0 13.940458731751164 -8.094393756811236 1.077694980056107 1.0012001155497898 1.180677636210205 0.6719042808395337 0.04283352032665147 0.2889979688447141 0.6351201866324471 0.039784714068786586 0.013899701576167156 8.04648568860741e-09 8.094393756811236 0.1794775206604151 S(ph)LCHDEIENLLDSDHR ddPTM_A459_Selumetinib_30min_R1 1 SLCHDEIENLLDSDHR 16 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 S(1)LCHDEIENLLDSDHR 171.85 8.2973e-09 0.0 1250.0 1277.7 742.99 921.33 1378.9 737.68 948.21 1066.8 268.29 671.18 True False 1279.1225679234024 1128.106290013385 642.0960389519331 760.4370110060543 1254.1787384645675 730.2596089598495 876.6857562917494 1038.504998545233 455.26853487368794 757.3324908468329 1.6889841428737793 1.4895786245113567 0.8478390227705075 1.0040992829394524 1.6560477117021242 0.9642523168962274 1.157596916661344 1.3712669284583303 0.6011475017592557 1.0 9.564783013873615 -5.069526351783556 5.3558202481940205 1.1066635951671937 1.647207662142677 0.36789687618952016 0.27239717401675034 0.20615434674206154 11.045544454541476 0.0685414928302791 0.19924509705011642 8.520668087620509e-06 5.069526351783556 0.5405440669754833 S(ph)LCHDEIENLLDSDHR ddPTM_A459_Selumetinib_30min_R2 3 SLCHDEIENLLDSDHR 16 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 S(1)LCHDEIENLLDSDHR;S(1)LCHDEIENLLDSDHR;S(1)LCHDEIENLLDSDHR 137.85 0.0002687 8466100.0 26259.4 19603.2 30016.100000000002 40927.8 46723.9 33704.0 33188.6 38605.700000000004 36436.7 37337.6 True False 24800.00767270698 21106.702405777218 28084.896805058655 35353.36303560698 40854.02596503419 38346.42006555027 34731.935661963296 38718.03619548234 43725.05812646061 36259.56647326475 0.6839576444189635 0.5821002416380189 0.774551367727093 0.9750078799666305 1.1267102709337982 1.0575531865176662 0.9578695787102744 1.0678019612846252 1.2058902623311945 1.0 15.146074055579948 -5.703484112383372 2.301795481635131 1.0663712636843183 0.634018285753993 0.8700118769276688 0.06857627558352132 0.0972064930546378 1.046107677698741 0.020678976752021273 0.040901612211245754 1.9793194285427177e-06 5.703484112383372 -0.43235297793032534 S(ph)LCLSPSEASQMK ddPTM_A459_Selumetinib_30min_R2 1 SLCLSPSEASQMK 13 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 S(0.433)LCLS(0.346)PS(0.218)EAS(0.004)QMK 149.82 0.00050901 7798200.0 35977.0 24920.0 29655.0 44920.0 42750.0 44434.0 46862.0 52424.0 52530.0 29334.0 True False 33977.54236734197 26831.28386957068 27747.02958592271 38801.818508677825 37379.362810150946 50554.38016830826 49041.175855291396 52576.545160739624 63037.46781083285 28487.051201114897 1.1927363814339687 0.9418764925911527 0.9740225265869841 1.3620861715290222 1.312152758327195 1.7746441992679716 1.7215251767923272 1.8456296086792563 2.2128463688921847 1.0 14.798018670298426 -6.4282336380497656 1.3246356861583242 1.7791736448197644 1.0380671621588522 0.4632878776990361 0.30162540245012925 0.33859300279421256 1.2187347322526194 0.11975588696998839 0.1458057554589772 3.730494138540848e-07 6.4282336380497656 -0.7411064826609122 S(ph)LDDLSAPPHHR ddPTM_A459_Selumetinib_30min_R1 3 SLDDLSAPPHHR 12 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(1)LDDLSAPPHHR;S(1)LDDLSAPPHHR;S(1)LDDLSAPPHHR 142.1 0.00061944 19042000.0 12303.2 12702.599999999999 13677.900000000001 15082.5 15116.8 12389.8 12627.0 11500.5 5634.2 8827.2 True False 12589.840622140167 11215.373686721465 11820.51630732668 12448.624508589544 13749.488109087812 12265.169861038317 11674.535223943973 11195.469381111228 9560.825894313366 9960.257104209259 1.2640075944244082 1.1260124682907822 1.1867681911876817 1.2498296357559573 1.3804350595806612 1.2314109698890192 1.1721118342427377 1.1240140956180702 0.9598975000628156 1.0 13.2819672677366 -7.955484662172116 1.7842255795015989 0.9776570547036636 1.2363240153239865 0.7137984722329724 0.06344390532149229 0.22017703586785048 1.2801933745428362 0.059039020020778675 0.020223948562865326 1.1079376933353485e-08 7.955484662172116 0.2586669606203229 S(ph)LDDLSAPPHHR ddPTM_A459_Selumetinib_30min_R2 2 SLDDLSAPPHHR 12 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(0.998)LDDLS(0.002)APPHHR;S(0.998)LDDLS(0.002)APPHHR 159.58 0.00030739 25995000.0 111486.0 112616.0 138199.0 153694.0 146917.0 110376.0 114411.0 139253.0 119387.0 152431.0 True False 105290.05443381832 121253.28508248711 129307.42679969409 132760.61206306194 128459.97300535566 125579.29210643198 119731.33820109564 139658.20317542471 143267.73595149256 148029.92096669908 0.7112754890783496 0.8191133541830664 0.8735222308791423 0.896849847625926 0.8677973491200749 0.8483372232204487 0.8088320078751544 0.943445772742406 0.967829578073761 1.0 17.175529288584094 -1.5228787453698143 0.10426136480328549 1.0675382826137279 0.19281180233016285 0.6601604552009724 0.046803862992628634 87.25944093620016 0.6431488838637819 0.5805957829468971 10.937105272148287 0.02999999999381917 1.5228787453698143 -0.874726480283565 S(ph)LDEADSENKEEVSPLGSK ddPTM_A459_Selumetinib_30min_R1 3 SLDEADSENKEEVSPLGSK 19 1 Q6ZV73-2;Q6ZV73;F8VQX5 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 S(1)LDEADSENKEEVSPLGSK;S(1)LDEADSENKEEVSPLGSK;S(0.989)LDEADS(0.01)ENKEEVSPLGSK 94.671 0.00098764 41136000.0 3568.1 3570.6 3395.25 3615.5 3165.3199999999997 2982.73 3197.34 3082.68 1070.0800000000002 2848.3399999999997 True False 3651.2297876859952 3152.5524920730945 2934.193698773272 2984.1207963404954 2879.017364882635 2952.726444302156 2956.162069606797 3000.917312444152 1815.8476044490524 3213.9521841810983 1.1360560389346033 0.9808958912300532 0.912954994543857 0.9284894812773442 0.8957872425896705 0.9187213359412496 0.9197903080689469 0.9337156063536064 0.5649889918669474 1.0 11.650132750029183 -1.5228787453609518 0.5323502936876069 0.863977218444965 11.184802155158824 0.3471962377049008 0.10951150089869713 143.77930187467615 1.391066389378191 0.054881860907113084 1684.5714627681818 0.029999999994431367 1.5228787453609518 10.320824936713858 S(ph)LDEADSENKEEVSPLGSK ddPTM_A459_Selumetinib_30min_R2 2 SLDEADSENKEEVSPLGSK 19 1 Q6ZV73-2;Q6ZV73;F8VQX5 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 S(1)LDEADSENKEEVSPLGSK;S(0.999)LDEADS(0.001)ENKEEVSPLGSK 103.31 0.00055618 49414000.0 102745.0 111390.0 112717.0 90257.0 77921.0 51003.0 69981.0 63671.0 60940.0 87114.0 True False 97034.84422082298 119933.25482469809 105464.91093699043 77963.84089799055 68131.86735742156 58028.20029086348 73235.25516472073 63856.27206869848 73129.70280586634 84598.79247064596 1.1470003458322655 1.4176710012298634 1.246647946820099 0.9215715570058804 0.8053527168376773 0.6859223234303028 0.8656773108213318 0.7548130440615366 0.8644296291964314 1.0 16.368349450589193 -5.812697120552951 3.1381942272314727 0.814554147785772 1.2962280429927526 0.8007072884075883 0.09858272117747933 0.09196768022478621 1.8405867286999227 0.027320052615397942 0.04560321032066419 1.5392277322630097e-06 5.812697120552951 0.4816738952069807 S(ph)LDGAEFSR ddPTM_A459_Selumetinib_30min_R1 2 SLDGAEFSR 9 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(1)LDGAEFSR;S(1)LDGAEFSR 120.77 0.0064738 14754100.0 2904.8 4189.700000000001 2503.6000000000004 2450.1 3255.5 2643.2 3213.3 3069.6 1968.81 3090.9 True False 2972.476188243122 3699.1679762613135 2163.6248712904076 2022.2360290731147 2961.0405998052065 2616.61180783358 2970.918193957327 2988.1842365339794 3340.9267738069475 3487.647122915579 0.8522869669676364 1.060648582236413 0.6203680576152083 0.5798281643191527 0.849008083515587 0.7502513057129939 0.8518402491000062 0.8567908768350216 0.9579314236969085 1.0 11.76803836153905 -8.112149987854052 1.2607559517615456 1.000083648278527 0.7849221800276223 0.2614504918374334 0.12536066770046697 0.6771729239334313 1.9892230770570933 0.12549479937783825 0.0415477086710838 7.724137783606008e-09 8.112149987854052 -0.21516146825090465 S(ph)LDGAEFSR ddPTM_A459_Selumetinib_30min_R2 2 SLDGAEFSR 9 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(1)LDGAEFSR;S(1)LDGAEFSR 120.77 0.0064738 32610000.0 81331.0 60659.0 75285.0 88437.0 93499.0 65988.0 88184.0 99885.0 83851.0 70715.0 True False 76810.94861378898 65311.35025057338 70441.24506411019 76391.72803766563 81752.81972833464 75077.2480205771 92284.730733281 100175.64881314809 100623.54299269253 68673.27421036469 1.1184984187370535 0.9510446531281902 1.0257446710394167 1.1123938521360908 1.1904604909022365 1.0932527811415444 1.3438230781102425 1.4587283039146082 1.4652504070863956 1.0 16.067461129744167 -7.257045984052856 4.561467722720055 1.3578842277665586 1.0778635382161277 0.40675197070942604 0.1356847781990943 0.17193144780428254 9.800468792759377 0.05516266383256095 0.0393323665342853 5.5329152239348437e-08 7.257045984052856 -0.2800206895504309 S(ph)LDGAPIGVMDQSLMK ddPTM_A459_Selumetinib_30min_R1 1 SLDGAPIGVMDQSLMK 16 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 S(1)LDGAPIGVMDQSLMK 206.81 7.6426e-08 11729000.0 693.12 904.47 1036.4 965.57 985.85 992.64 892.41 800.94 475.12 648.09 True False 709.2683474232555 798.574231923305 895.6625725376974 796.9513254937057 896.6800415659545 982.6549428450083 825.094795216587 779.6964693802203 806.2439386081725 731.278664431187 0.9699016010195621 1.0920245191953777 1.2247896952311246 1.0898052469691577 1.2261810513279807 1.3437489573271635 1.1282905345780507 1.0662097874641183 1.102512595845109 1.0 9.514277460773133 -7.668950104844577 4.566205804315464 1.063181321074147 1.1633331641536142 0.17513346549047237 0.09698080124561424 0.41063099292510746 14.963265449559554 0.051982989358258715 0.028473281775467096 2.1431368073376912e-08 7.668950104844577 0.10015184307946723 S(ph)LDGLSEACGGAGSSGSAESGAGGGR ddPTM_A459_Selumetinib_30min_R2 3 SLDGLSEACGGAGSSGSAESGAGGGR 26 0 Q96GS4 Q96GS4 C17orf59 Uncharacterized protein C17orf59 1 S(0.97)LDGLS(0.03)EACGGAGSSGSAESGAGGGR;S(0.927)LDGLS(0.073)EACGGAGSSGSAESGAGGGR;S(0.974)LDGLS(0.026)EACGGAGSSGSAESGAGGGR 196.78 6.3601e-32 11192500.0 28129.9 27521.2 30156.4 32715.1 31020.5 24147.5 28359.8 24361.2 24568.8 23884.5 True False 26566.552770911767 29631.987545394404 28216.17005580574 28259.246943304675 27123.427463211407 27473.59893581997 29678.586893877593 24432.08705878625 29483.24650962861 23194.892425616323 1.1453621893745798 1.2775220941602206 1.2164820400134273 1.2183392112694305 1.1693706944403168 1.1844676160462924 1.279531129064462 1.0533390976973696 1.2711094308446742 1.0 14.501519534752514 -14.03085926017219 0.26640804732657836 8.672515700169242e-10 1.2167381334258403 0.4438196295226301 0.06681676873550689 133.49597089220208 1.6637572059237562 72.8095936995867 0.07894626110514844 9.314096642384208e-15 14.03085926017219 1.2167381325585886 S(ph)LDGLSR ddPTM_A459_Selumetinib_30min_R2 2 SLDGLSR 7 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 S(1)LDGLSR;S(1)LDGLSR 83.948 0.038343 3406800.0 15885.5 16359.4 18542.1 20828.1 24757.0 15905.3 14815.6 18210.8 15796.0 19820.1 True False 15002.647504694969 17614.113376238158 17349.121473112034 17991.27684952343 21646.804329611863 18096.11070106211 15504.554756554462 18263.790413039762 18955.641377116233 19247.842214195723 0.7794456821570458 0.9151214551856284 0.9013540988151213 0.934716559358246 1.1246353793178359 0.9401630842399473 0.8055217090838109 0.9488746951369852 0.9848190340596212 1.0 14.232409100610699 -4.110690138126344 1.1151491903124449 0.9557783513201664 0.27709071027959714 0.3356781498744177 0.07530071784067686 8.346086631942574 2.9667512274690613 0.02486438704688966 9.570743790168546 7.75014560555933e-05 4.110690138126344 -0.6786876410405693 S(ph)LDGSGSEPAVCEMCGIVGTR ddPTM_A459_Selumetinib_30min_R1 2 SLDGSGSEPAVCEMCGIVGTR 21 0 Q969R5;H7C228;Q969R5-2;Q969R5-3 Q969R5 L3MBTL2 Lethal(3)malignant brain tumor-like protein 2 1 S(0.97)LDGS(0.004)GS(0.026)EPAVCEMCGIVGTR;S(1)LDGSGSEPAVCEMCGIVGTR 231.42 5.0784e-25 20850400.0 1785.0 2321.12 2289.84 2785.85 1590.11 1681.5 2059.46 1699.56 923.3399999999999 1836.89 True False 1826.58702699462 2049.362191340587 1978.8923051907764 2299.353594381184 1446.2848312567216 1664.5856366798455 1904.1132741192412 1654.4821478510833 1566.8405419146109 2072.672724323787 0.8812713196631403 0.9887533942480933 0.9547538701926004 1.1093664558794982 0.6977873613542025 0.8031106971907104 0.9186753179957349 0.7982360786799377 0.7559517349396274 1.0 11.017276617091015 -6.262142981262836 24.9999586883221 0.8220652861793621 0.9818530238501398 0.39089215688932477 0.09428453197408522 65.45128374724857 2325569.523885332 0.02803793330869557 0.03372086852546412 5.46835900372031e-07 6.262142981262836 0.1597877376707777 S(ph)LDGSGSEPAVCEMCGIVGTR ddPTM_A459_Selumetinib_30min_R2 2 SLDGSGSEPAVCEMCGIVGTR 21 0 Q969R5;H7C228;Q969R5-2;Q969R5-3 Q969R5 L3MBTL2 Lethal(3)malignant brain tumor-like protein 2 1 S(0.582)LDGS(0.013)GS(0.405)EPAVCEMCGIVGTR;S(0.999)LDGS(0.001)GSEPAVCEMCGIVGTR 155.88 1.9424e-07 9212700.0 13430.900000000001 13060.0 12576.3 13209.9 13837.9 13967.8 12181.8 12504.1 8920.0 11907.4 True False 12684.464346152638 14061.660005481268 11767.154550040112 11410.688831651458 12099.459289604405 15891.73766293595 12748.277837778769 12540.484860834811 10704.249245624009 11563.602422859334 1.0969301678063181 1.2160276262770575 1.017602829960531 0.9867763015696915 1.0463399593958513 1.3742895234378352 1.1024486463299297 1.0844790751404891 0.9256846486232936 1.0 13.497303291917945 -8.121349754435423 4.067071850799135 0.9644292529801332 1.1202414840478936 0.2551574062234443 0.10555789172789465 0.3514431797523588 9.533870518842571 0.08439837921793743 0.029245971957412343 7.562236330740739e-09 8.121349754435423 0.15581223106776043 S(ph)LDNNYSTPNER ddPTM_A459_Selumetinib_30min_R1 2 SLDNNYSTPNER 12 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;C9JZR2;O60716-19;O60716-11;O60716-13;O60716-21;O60716-9;O60716-17;O60716-10;O60716-18;O60716-27;O60716-29;O60716-25;O60716-26;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 S(1)LDNNYSTPNER;S(1)LDNNYSTPNER 182.02 0.00010416 20352000.0 2608.8999999999996 3125.8999999999996 3589.7 3661.3 3425.3 2918.6 3334.0 3274.2 2051.1400000000003 2498.74 True False 2669.682293964293 2759.9181748085152 3102.2384568106622 3021.922686112975 3115.4822197858316 2889.2415338767732 3082.5136957812024 3187.357579899514 3480.6347706616593 2819.4776187887232 0.9468712488348164 0.9788757166989694 1.100288378293074 1.0718023317422978 1.1049856182665054 1.0247435605174342 1.0932924862533515 1.1304780568780808 1.2344963292019235 1.0 11.461212175444308 -5.1950505490891 3.518395251892489 1.0972126431627252 0.9525987689216636 0.44249125643311793 0.05963802729614803 0.22070051513262204 5.348429617693635 0.015891002386940644 0.04885612502430249 6.381892007422882e-06 5.1950505490891 -0.14461387424106154 S(ph)LDNNYSTPNER ddPTM_A459_Selumetinib_30min_R2 2 SLDNNYSTPNER 12 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;C9JZR2;O60716-19;O60716-11;O60716-13;O60716-21;O60716-9;O60716-17;O60716-10;O60716-18;O60716-27;O60716-29;O60716-25;O60716-26;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 S(1)LDNNYSTPNER;S(1)LDNNYSTPNER 147.39 0.00063095 20621700.0 116626.0 96571.0 127961.0 121314.0 116180.0 86627.0 105328.0 98316.0 80607.0 93569.0 True False 110144.39381086873 103977.68517529317 119728.1285734024 104790.82392167726 101584.42973762195 98559.08292838917 110225.96070347252 98602.08328291008 96730.65234775949 90867.41984854155 1.2121439564858139 1.1442790534671712 1.3176133841256423 1.1532276815644522 1.1179411708502738 1.0846470945545512 1.2130416037695129 1.0851203153700273 1.0645251346301108 1.0 16.471475494119076 -7.780844130629035 0.2791407567512003 0.977725372664141 1.2429550442471644 0.5397311352579706 0.05841321110151176 1.4272806954392476 0.41420529467149103 0.1271560021225119 0.13887782901969914 1.656364330085798e-08 7.780844130629035 0.26522967158302346 S(ph)LDQPFLSK ddPTM_A459_Selumetinib_30min_R2 2 SLDQPFLSK 9 0 G5E9Y3;Q8WWN8;Q8WWN8-2 G5E9Y3 ARAP3 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 1 S(1)LDQPFLSK;S(1)LDQPFLSK 127.56 0.0035665 0.0 36013.0 33944.0 44670.0 39321.0 34204.0 25400.5 33285.0 34555.0 30006.0 36257.0 True False 34011.541631461376 36547.39565283736 41795.98083301861 33965.41196749157 29906.9877323603 28899.18831221845 34832.81845297624 34655.54932911179 36008.03843768994 35210.166203000736 0.9659579973400634 1.037978504336701 1.1870429861662115 0.9646478739028763 0.8493850202221289 0.8207626213861938 0.9892829886729606 0.9842483880737354 1.0226602802749964 1.0 15.103704416738537 -5.978022417413039 24.971571250652467 0.9366974750083558 1.063550716450522 0.3112922094259756 0.07931967708019529 281.5100196784111 319857.6677097199 0.02396384045562727 0.035541325437874145 1.0519075750554844e-06 5.978022417413039 0.12685324144216625 S(ph)LDSESISPGDFHR ddPTM_A459_Selumetinib_30min_R1 2 SLDSESISPGDFHR 14 0 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 S(0.796)LDS(0.204)ESISPGDFHR;S(0.952)LDS(0.048)ESISPGDFHR 115.38 0.0018554 4372900.0 1498.05 1683.53 1513.87 1416.7 2181.34 1489.85 1553.4 1588.78 711.64 1166.3899999999999 True False 1532.9516503021232 1486.4215249481365 1308.2947690926699 1169.2999397526157 1984.038182146856 1474.8634616755667 1436.225787350486 1546.6403933152383 1207.6011038708539 1316.1075181007147 1.1647617152999308 1.1294073656635617 0.9940637456282299 0.8884532028508141 1.5075046338235627 1.120625360307913 1.0912678239412497 1.1751626459418811 0.9175550532630895 1.0 10.362061638092777 -8.261929836351875 24.990882336904818 0.9587775184087883 1.1315020546644792 0.17729626680332422 0.15082854559839642 80.08079615896753 4079816.73948371 0.12273735941149622 0.039094300269226626 5.471043447124162e-09 8.261929836351875 0.17272453625569084 S(ph)LDYLNLDK ddPTM_A459_Selumetinib_30min_R1 2 SLDYLNLDK 9 0 Q96GV9 Q96GV9 C5orf30 UNC119-binding protein C5orf30 1 S(1)LDYLNLDK;S(0.998)LDY(0.002)LNLDK 167.84 0.00081147 6683500.0 2328.77 2971.3999999999996 3138.2 3460.2 2916.7 2643.7 3081.0 3065.6 1757.0700000000002 2541.5 True False 2383.025810002386 2623.507106633616 2712.0496768986895 2855.9410259984465 2652.884999985209 2617.106778287544 2848.5976894726687 2984.2903295278097 2981.619458684675 2867.7262813063953 0.8309809152764736 0.9148387430610968 0.9457142735614268 0.9958903834774008 0.9250830587557628 0.9126068953468315 0.9933297009695735 1.0406468528678106 1.0397154979959926 1.0 11.485691612939313 -1.8180868003457369 0.2667918595755056 1.02296509001582 1.1103134631120356e-15 0.6555982443358312 0.03674879423759356 31.418662362435516 0.5041497050563137 0.04950888290976049 14.2973037536013 0.015202436555914238 1.8180868003457369 -1.022965090015819 S(ph)LDYLNLDK ddPTM_A459_Selumetinib_30min_R2 2 SLDYLNLDK 9 0 Q96GV9 Q96GV9 C5orf30 UNC119-binding protein C5orf30 1 S(1)LDYLNLDK;S(1)LDYLNLDK 120.03 0.0067078 4930100.0 18347.1 19871.8 23084.9 21097.1 23903.2 16359.7 17798.0 17082.6 15649.3 17776.7 True False 17327.441631260517 21395.90316209208 21599.64266693869 18223.638585472545 20900.266318680715 18613.10017642959 18625.64226606795 17132.307537823322 18779.59727797578 17263.440481586527 1.0037073229836344 1.2393765417104028 1.251178332035102 1.0556203211584725 1.210666340870656 1.078180226953175 1.0789067385457938 0.9924040086966979 1.0878247182539547 1.0 14.075432391638074 -7.1049183735619446 1.9707132312138713 1.0336842146300702 1.1572110070309516 0.3112063120772286 0.07803838390781535 0.40344918392321444 3.094331661141616 0.036042526495279045 0.02581701104140281 7.853832349467435e-08 7.1049183735619446 0.12352679240088138 S(ph)LEDISSDSSNQAK ddPTM_A459_Selumetinib_30min_R1 1 SLEDISSDSSNQAK 14 0 A0A0U1RR07;Q9HCH5-15;Q9HCH5-14;Q9HCH5-6;Q9HCH5;Q9HCH5-13;A0A0U1RRJ3;A0A0U1RQP0;Q9HCH5-11;Q9HCH5-7;Q9HCH5-8;A0A0U1RQH1;Q9HCH5-12 A0A0U1RR07 SYTL2 Synaptotagmin-like protein 2 1 S(1)LEDISSDSSNQAK 108.36 0.0049121 3659000.0 1012.9 871.86 913.41 803.54 902.63 956.91 861.33 806.06 390.58 921.1 True False 1036.4985992396923 769.782225883282 789.3739390019857 663.21682331391 820.9872758722698 947.2843542047636 796.3591846392382 784.6806703481162 662.7857331654745 1039.3321572737843 0.9972736742394995 0.740650830916707 0.7595011214437448 0.6381182557206332 0.7899180931972286 0.9114356248627328 0.766222019655511 0.7549854633636752 0.637703479611361 1.0 10.021441079491472 -10.992179188751253 5.547217702255158 1.0002560798918538 0.7749487381821618 0.29269629342933356 0.1037928871418711 0.0003308282240867316 3.165005910530626e-05 0.10114298210087853 0.02450315885670188 1.0181712066380824e-11 10.992179188751253 -0.22530734170969202 S(ph)LEDISSDSSNQAK ddPTM_A459_Selumetinib_30min_R2 2 SLEDISSDSSNQAK 14 0 A0A0U1RR07;Q9HCH5-15;Q9HCH5-14;Q9HCH5-6;Q9HCH5;Q9HCH5-13;A0A0U1RRJ3;A0A0U1RQP0;Q9HCH5-11;Q9HCH5-7;Q9HCH5-8;A0A0U1RQH1;Q9HCH5-12 A0A0U1RR07 SYTL2 Synaptotagmin-like protein 2 1 S(1)LEDISSDSSNQAK;S(1)LEDISSDSSNQAK 220.46 7.6899e-09 13506300.0 42875.0 46821.0 41156.0 47754.0 40356.0 28626.0 31629.0 37992.0 26748.0 35533.0 True False 40492.17914222384 50412.0201467564 38508.067767264685 41249.82281975515 35286.11849278252 32568.971659044724 33099.81117167452 38102.5504300858 32098.34740156404 34507.069964178634 1.173445881793449 1.4609185943370009 1.1159471901624634 1.195402068694215 1.0225764902500447 0.9438347472808956 0.9592182473340978 1.1041954726854408 0.9301962593429387 1.0 15.074604357593811 -5.925366281664406 1.3407147211563313 0.9901335203014209 1.3042615149225452 0.6327947389729609 0.09253298328696061 0.2655764097467037 0.9684590764224787 0.03144579260969894 0.06278660971819372 1.1875002735378019e-06 5.925366281664406 0.3141279946211243 S(ph)LEDLHQK ddPTM_A459_Selumetinib_30min_R2 1 SLEDLHQK 8 0 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 S(1)LEDLHQK 103.26 0.010294 4169600.0 30133.0 25045.0 27776.0 34055.0 32464.0 26852.0 32079.0 33798.0 25674.0 33101.0 True False 28458.328491956407 26965.870967632345 25988.922400222174 29416.650251848252 28385.582088157687 30550.61926181333 33570.737063332606 33896.34658443989 30809.517391496734 32145.288123273487 0.88530326381963 0.8388747633625596 0.8084831064682837 0.9151154638601706 0.8830402135237438 0.9503918317563437 1.0443439466024595 1.0544732545078237 0.9584458311073702 1.0 14.972319661445587 -6.843970688760817 1.8310734972571714 1.0192827725451512 0.8573545161453848 0.7875428244081043 0.03630538629071424 0.15209452108618385 1.0492527494095658 0.015916706902201733 0.013701213455112285 1.4322845632204137e-07 6.843970688760817 -0.16192825639976638 S(ph)LEDVTAEYIHK ddPTM_A459_Selumetinib_30min_R1 1 SLEDVTAEYIHK 12 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 S(1)LEDVTAEYIHK 137.73 0.00086 2674200.0 2136.8 2110.8 2219.4 1916.7 2168.6 1978.7 2312.0 2193.4 1137.7 1908.1 True False 2186.5832825109815 1863.666554715703 1918.017670291554 1581.9843259150393 1972.4505128974274 1958.7960745158541 2137.60397859812 2135.2239068326903 1930.5938056796574 2153.023221467927 1.015587412485116 0.8656044840264465 0.8908485756989899 0.7347734618656112 0.9161306265673318 0.9097886427719765 0.9928383295098442 0.9917328738223727 0.8966897274630332 1.0 11.072148164462615 -6.956247250296301 2.531234876546015 0.9687215176829876 0.8749195371465552 0.24595813182484072 0.06987354554491114 0.40626215697534396 5.270446101888543 0.028963261313188417 0.023780736871093933 1.1059939459330426e-07 6.956247250296301 -0.0938019805364324 S(ph)LEEDLETLK ddPTM_A459_Selumetinib_30min_R2 1 SLEEDLETLK 10 0 P48681 P48681 NES Nestin 1 S(1)LEEDLETLK 105.13 0.012697 1093600.0 8786.8 9646.5 11248.0 11276.0 10370.0 8669.0 9983.2 7861.2 8460.3 10005.0 True False 8298.464832347336 10386.355531613708 10524.315925896422 9740.189347815029 9067.227891023751 9863.076060653197 10447.43858133552 7884.074790508283 10152.596400532826 9716.129653888134 0.8540916113677541 1.0689807466142 1.083179856671105 1.0024762631607398 0.9332139662623059 1.0151239652000998 1.0752675142776358 0.8114419085950842 1.0449218734406276 1.0 13.246166026362236 S(ph)LEEMSLR ddPTM_A459_Selumetinib_30min_R1 2 SLEEMSLR 8 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(1)LEEMSLR;S(1)LEEMSLR 119.53 0.0078327 10152000.0 1155.49 1246.5100000000002 1231.72 1350.42 1452.6599999999999 1305.74 1440.81 1303.12 866.3299999999999 1051.29 True False 1182.4106688078502 1100.5680297132233 1064.459189353659 1114.5944975229245 1321.2671594879528 1292.6054411170617 1332.128541697214 1268.5570244696885 1470.0987357602676 1186.2333119317727 0.9967774947091165 0.9277837830409229 0.8973438687370823 0.9396081582870195 1.113834138864536 1.0896721817835842 1.1229903327599626 1.069399258737602 1.2392998248938245 1.0 10.21217207604957 -6.259621586169338 21.15251299091531 1.1093824876744527 0.9364047421268596 0.6437921101070649 0.060241508117472406 11.233789880003913 130714.47114237577 0.017321606086885682 0.021179702692243906 5.500199140029557e-07 6.259621586169338 -0.17297774554759304 S(ph)LEEMSLR ddPTM_A459_Selumetinib_30min_R2 3 SLEEMSLR 8 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(1)LEEMSLR;S(1)LEEMSLR;S(1)LEEMSLR 128.35 0.0043517 6021600.0 11465.0 9298.4 15362.0 14872.0 17651.6 15230.9 17826.5 20469.600000000002 17635.8 12858.1 True False 10827.821198031403 10011.55738093162 14373.62564488095 12846.40794436903 15434.048200693822 17328.81822265577 18655.467572539612 20529.1631470753 21163.452785423313 12486.853243644087 0.8671376996876978 0.8017678421925545 1.1511007108373958 1.0287946605689435 1.236023832389468 1.3877650265070811 1.4940087152890502 1.6440621785576612 1.6948587744631087 1.0 13.60812233513662 -6.276093113662059 0.9210474530963964 1.5157828449854311 0.8621762436627878 0.5875552508090236 0.1923254788518476 0.37571848060008406 0.6808431865533278 0.09212628909819055 0.14582894327714646 5.295498950939798e-07 6.276093113662059 -0.6536066013226434 S(ph)LEGGGCPAR ddPTM_A459_Selumetinib_30min_R1 3 SLEGGGCPAR 10 0 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 S(1)LEGGGCPAR;S(1)LEGGGCPAR;S(1)LEGGGCPAR 130.01 0.0028521 97230000.0 1739.48 2387.65 2316.4700000000003 2341.17 2592.3199999999997 2223.58 2008.4399999999998 1783.0900000000001 1262.73 1940.6499999999999 True False 1780.0064995611212 2108.1028280116284 2001.9060974588972 1932.3286087037686 2357.845113711269 2201.212804049104 1856.941753795678 1735.7966609074056 2142.7605838497598 2189.7513310317768 0.812880656509253 0.9627133447240893 0.9142161802069234 0.8824420295218113 1.076763868251784 1.0052341436467704 0.8480148989888802 0.792691223112318 0.9785406011558967 1.0 11.096551330809724 -4.7531193377234695 24.764877091492718 0.9344128511320409 0.8128804010617189 0.184718747320043 0.0793648669086904 550.0736969564689 1637168.4973719206 0.021062318471757734 0.23173812981342776 1.7655526061869253e-05 4.7531193377234695 -0.12153245007032198 S(ph)LEGGGCPAR ddPTM_A459_Selumetinib_30min_R2 3 SLEGGGCPAR 10 0 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 S(1)LEGGGCPAR;S(1)LEGGGCPAR;S(1)LEGGGCPAR 107.03 0.011542 116514000.0 32418.7 28556.2 34069.5 41883.0 39650.0 28132.4 31836.7 34166.2 27388.9 38304.0 True False 30616.998436338476 30746.368717344878 31877.505462066878 36178.46314779506 34668.81252450258 32007.382739499375 33317.169633224235 34265.617985481105 32867.44530980624 37198.06399425603 0.8230804280853494 0.8265583048110408 0.8569667891046499 0.9725899485893026 0.932005830460854 0.8604582954758565 0.8956694530760777 0.921166703481457 0.8835794603418471 1.0 15.182939916512636 -1.5228787452803376 0.058070347686421955 1.1223296537828868 0.43596910197011374 0.481019969263487 0.04054646109811077 377.99876489922144 1.6497163967091073 4.073073279496386 22.16517229287586 0.029999999999999995 1.5228787452803376 -0.6863605518127731 S(ph)LELNGAVEPSEGAPR ddPTM_A459_Selumetinib_30min_R1 2 SLELNGAVEPSEGAPR 16 0 F5GYK2;Q9NRL3;Q9NRL3-3;R4GN16;M0R2A7;M0QYS2;M0R0P4;Q9NRL3-2 F5GYK2 STRN4 Striatin-4 1 S(1)LELNGAVEPSEGAPR;S(1)LELNGAVEPSEGAPR 187.75 8.780899999999998e-07 15508700.0 2210.7 2413.2 2517.5 2993.6000000000004 2647.4 2056.36 2107.27 2282.79 1271.06 2194.06 True False 2262.2050087266134 2130.6614221337572 2175.6373276376435 2470.823956831672 2407.943137436433 2035.6748854254927 1948.3169273271903 2222.24299365305 2156.895985450633 2475.6889729542063 0.9137678575298394 0.8606337247571401 0.8788007505811543 0.9980348839552616 0.9726355627633898 0.8222660066205123 0.7869796846904763 0.897626082246219 0.8712305984369426 1.0 11.273614361184336 -6.766471501244625 24.999006118911442 0.8636820616706588 0.9227270933757729 0.1135743843485032 0.06435667017618396 246.40129304215685 1224084.5158621115 0.023120502279913382 0.021020820670055503 1.7120975222417202e-07 6.766471501244625 0.059045031705114104 S(ph)LELSSLAGPGEDPLSADSLGKPTR ddPTM_A459_Selumetinib_30min_R2 1 SLELSSLAGPGEDPLSADSLGKPTR 25 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 S(1)LELSSLAGPGEDPLSADSLGKPTR 98.722 0.00083974 0.0 30755.0 20396.0 33384.0 41650.0 32988.0 28074.0 35308.0 22040.0 27311.0 35504.0 True False 29045.76022201966 21960.307616523416 31236.109785750916 35977.198149742464 28843.75252353826 31940.938669601786 36949.89196147469 22104.13275108158 32773.963133098376 34478.907269529685 0.8424211357675043 0.6369200579604961 0.9059483684204647 1.043455289011925 0.8365622581382843 0.9263906892382637 1.0716665604460356 0.6410914527623628 0.9505510971358992 1.0 15.073426431766144 -5.342462465786397 8.59236309611733 0.9163054257523953 0.7400990456603292 0.2584982960934046 0.12323676922756922 0.434600604919448 42.60749121256394 0.031666230682375666 0.06615741832981918 4.54503816332017e-06 5.342462465786397 -0.17620638009206602 S(ph)LEPAENVHGAGGGAFPASQTPSK ddPTM_A459_Selumetinib_30min_R2 2 SLEPAENVHGAGGGAFPASQTPSK 24 0 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 S(1)LEPAENVHGAGGGAFPASQTPSK;S(1)LEPAENVHGAGGGAFPASQTPSK 140.64 2.6938e-08 19479000.0 66271.0 38470.0 52181.0 67457.0 63181.0 56029.0 90364.0 84263.0 78106.0 43957.0 True False 62587.923123832355 41420.52529945361 48823.73127037708 58269.240230184376 55243.63793469355 63746.48616937804 94566.10505286897 84508.19137950933 93729.38246398105 42687.847195998125 1.4661766107919307 0.9703118807859835 1.143738428555708 1.3650077026055079 1.2941303336531924 1.4933169591966238 2.2152933742166856 1.9796779863715346 2.1956924188195637 1.0 15.381537786970513 -7.026869523388749 3.846046208638729 1.9284728175253452 1.2391091187662777 0.39454170830803137 0.34303073174586163 0.1954882058182095 6.275590890645518 0.12649425121217694 0.10156463086248797 9.400056773420063e-08 7.026869523388749 -0.6893636987590674 S(ph)LEPAENVHGAGGGAFPASQTPSKPASADGHR ddPTM_A459_Selumetinib_30min_R1 4 SLEPAENVHGAGGGAFPASQTPSKPASADGHR 32 1 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 S(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR;S(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR;S(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR;S(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR 179.43 8.215299999999998e-35 318439000.0 9968.1 10628.900000000001 7196.7 6412.700000000001 12184.8 9028.2 12704.699999999999 10321.5 2431.31 6569.6 True False 10200.337335453813 9384.463446758444 6219.427668643426 5292.842326287565 11082.686991401166 8937.384504949727 11746.374250387344 10047.740291042952 4125.755494143449 7412.872153323035 1.3760303866674966 1.2659686087465554 0.8390037680408918 0.7140069620538235 1.4950597773945191 1.2056574456020108 1.5845915061575278 1.3554449723699553 0.5565663900319608 1.0 12.855816914712108 -8.254522388126025 24.93528655183732 0.7782831883682217 1.2203859483556763 0.30150615098780686 0.27441593642905093 638.7757906219506 2302764.7881689076 0.20876904270629354 0.07506101580862423 5.5651594480726246e-09 8.254522388126025 0.4421027599874545 S(ph)LEPAENVHGAGGGAFPASQTPSKPASADGHR ddPTM_A459_Selumetinib_30min_R2 3 SLEPAENVHGAGGGAFPASQTPSKPASADGHR 32 1 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 S(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR;S(1)LEPAENVHGAGGGAFPASQTPSKPASADGHR;S(0.707)LEPAENVHGAGGGAFPAS(0.219)QT(0.046)PS(0.02)KPAS(0.008)ADGHR 117.83 6.358e-17 290469000.0 101823.8 51544.4 117240.0 163722.0 155542.0 104276.0 126983.0 124985.0 130592.0 120184.0 True False 96164.84082896731 55497.68973863156 109696.90604126058 141422.7811637967 136001.42339687725 118639.07247671863 132887.96111204085 125348.68565761953 156714.04904535104 116713.97564446693 0.8239359536676549 0.4755016649221866 0.9398780688905527 1.2117039144874775 1.165253969337516 1.0164941415252267 1.1385779670195022 1.0739818000841268 1.3427187976419548 1.0 16.832617797999262 -5.489601627201446 4.638603191180646 1.1328658310649022 0.6539483605858594 0.7157803326579277 0.1216534256940034 0.09460112023951091 4.861517142229579 0.03095339149009927 0.06349298275114093 3.2389062145100747e-06 5.489601627201446 -0.4789174704790429 S(ph)LEQDALR ddPTM_A459_Selumetinib_30min_R1 1 SLEQDALR 8 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 S(1)LEQDALR 115.29 0.009917 3359000.0 1533.7 1315.6 1131.8 1198.5 1551.0 1063.6 1540.4 1512.7 693.97 842.03 True False 1569.4322259392982 1161.5689403941526 978.1077765323872 989.2044736313327 1410.71232385129 1052.9011496715323 1424.2063878168449 1472.5782820579054 1177.616404436593 950.1127525667622 1.6518378705047618 1.222559046024942 1.0294649491757641 1.0411442967784221 1.48478411645376 1.1081854725421627 1.4989867086504234 1.54989844950474 1.2394491088086355 1.0 9.891954922077703 -7.263087563870069 24.99657733209113 1.3679084275003213 1.2450854429291418 0.00228341341498417 0.2307371948836712 503.35969188814494 7633898.1178429155 0.09323025684868817 0.06664575844582994 5.4564783470341884e-08 7.263087563870069 -0.12282298457117946 S(ph)LEQDALR ddPTM_A459_Selumetinib_30min_R2 3 SLEQDALR 8 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 S(1)LEQDALR;S(1)LEQDALR;S(1)LEQDALR 119.03 0.0080786 12691800.0 45635.0 33439.8 44976.8 47880.6 36009.9 23429.3 64697.0 39725.4 38052.9 39495.9 True False 43098.78939137922 36004.52513409588 42083.04165503722 41359.17968135795 31486.014429409468 26656.473404990444 67705.53869467336 39840.994337105985 45664.54328686166 38355.55074432789 1.1236649860321135 0.9387044230989255 1.0971825677998004 1.0783101501279901 0.8208985093002659 0.6949834610035541 1.765208356568464 1.0387282561181257 1.190558925649494 1.0 15.227147756543197 -7.217919103945147 24.99999811099428 1.2518531657158245 0.9634695399232915 0.2767280554432855 0.22932467027018638 627.1269033372939 360250.2369118194 0.08678764167381028 0.06722502134429174 6.054536421311795e-08 7.217919103945147 -0.28838362579253296 S(ph)LEQEEPFDLSQKR ddPTM_A459_Selumetinib_30min_R1 2 SLEQEEPFDLSQKR 14 1 Q8N895 Q8N895 ZNF366 Zinc finger protein 366 1 S(1)LEQEEPFDLSQKR;S(1)LEQEEPFDLSQKR 78.324 0.01968 14549300.0 1386.8000000000002 1280.95 5393.799999999999 5610.8 3200.8999999999996 2458.9 1940.37 1661.51 1330.04 1044.8200000000002 True False 1419.1097417569406 1130.975778502501 4661.351586022608 4630.97910776027 2911.379160164795 2434.16569850257 1794.0063286991515 1617.4413574549023 2256.980737721868 1178.9328244086366 1.2037240056224399 0.9593216467357322 3.95387378272446 3.92811109494997 2.4695038596666175 2.064719590553066 1.5217205692775932 1.371953790722746 1.9144269215287903 1.0 10.203265800559446 -7.032399003485651 2.609143619253342 1.4802516636590457 2.572380702582387 0.21903572927002324 0.9307414411992211 0.5101007349875742 6.9279690454494025 0.43651972614040807 0.34174757248108634 9.281133006285316e-08 7.032399003485651 1.0921290389233411 S(ph)LESCLLDLR ddPTM_A459_Selumetinib_30min_R1 4 SLESCLLDLR 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 S(1)LESCLLDLR;S(1)LESCLLDLR;S(0.996)LES(0.004)CLLDLR;S(0.999)LES(0.001)CLLDLR 226.33 9.9436e-06 32046900.0 4069.55 4622.66 5079.75 4912.55 4292.49 3667.73 4266.02 3662.0699999999997 2385.7 3483.1800000000003 True False 4164.362597034148 4081.4368181836717 4389.94785106944 4054.665362484445 3904.2350374006637 3630.835966232391 3944.2306768075923 3564.940007520192 4048.3586553660525 3930.280082046354 1.0595587362989958 1.0384595329039796 1.1169554737645448 1.0316479431087588 0.9933732344509836 0.9238109983098066 1.0035495166934705 0.9070447736803676 1.030043297387147 1.0 11.940416411034347 -6.203549300446608 2.8366374645298436 0.9688480046536417 1.0685065450360662 0.5386369649569636 0.03961778695208527 0.1907203321948068 3.03361149368175 0.011857883795181145 0.01548947367086042 6.258218175516072e-07 6.203549300446608 0.0996585403824245 S(ph)LESCLLDLR ddPTM_A459_Selumetinib_30min_R2 5 SLESCLLDLR 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 S(0.812)LES(0.188)CLLDLR;S(1)LESCLLDLR;S(1)LESCLLDLR;S(1)LESCLLDLR;S(1)LESCLLDLR 147.62 0.00081756 5756600.0 25388.9 25570.199999999997 28124.1 28004.600000000002 28692.2 26119.7 25596.8 25891.600000000002 19954.260000000002 27625.1 True False 23977.8865778194 27531.352118848157 26314.626025204805 24190.325169370426 25087.6293244775 29717.451583970866 26787.10191909696 25966.94026941489 23945.669568608224 26827.491584370353 0.8937804156013183 1.0262365391957804 0.9808828358941936 0.9016991056839494 0.9351462937031917 1.1077238246636596 0.9984944673210923 0.9679227812913818 0.892579520276839 1.0 14.711424546038687 S(ph)LESINSR ddPTM_A459_Selumetinib_30min_R1 4 SLESINSR 8 0 P62888;E5RJH3;A0A0C4DH44;E5RI99 P62888 RPL30 60S ribosomal protein L30 1 S(1)LESINSR;S(1)LESINSR;S(1)LESINSR;S(0.998)LES(0.002)INSR 136.49 0.0025913 84099500.0 4569.24 4618.75 4129.04 4682.2 4841.9400000000005 3803.73 3995.8199999999997 4182.05 2380.79 3463.8 True False 4675.694401806662 4077.9846028013803 3568.3390471932203 3864.541665779412 4403.987381913938 3765.46792971051 3694.4120803468595 4071.1284487871153 4040.0267439782615 3908.4124702691697 1.196315495709349 1.0433864475211165 0.9129893721139087 0.9887752879657719 1.1267969835360387 0.9634264444589659 0.9452462114604879 1.0416322432076213 1.0336746120605913 1.0 11.932367013332447 -4.797909405742052 3.9030188619947324 1.002369965417661 1.211280290591314 0.5209041308167031 0.05582005668652719 0.18838657791590152 5.1933353402932605 0.01459225971779145 0.10821470490215876 1.5925408980089054e-05 4.797909405742052 0.20891032517365304 S(ph)LESINSR ddPTM_A459_Selumetinib_30min_R2 4 SLESINSR 8 0 P62888;E5RJH3;A0A0C4DH44;E5RI99 P62888 RPL30 60S ribosomal protein L30 1 S(1)LESINSR;S(1)LESINSR;S(1)LESINSR;S(0.999)LES(0.001)INSR 150.15 0.0013247 80968000.0 45115.299999999996 49203.200000000004 53612.1 58707.4 84991.7 52299.700000000004 33488.8 43476.7 36931.2 51225.5 True False 42607.97223685527 52976.9272267761 50162.75585444097 50711.35084408623 74314.28281056152 59503.50894559284 35046.09555679832 43603.209999044855 44318.471943945035 49746.486715167106 0.8565021381472676 1.0649380634677879 1.008367809804485 1.0193956235430983 1.4938599229340952 1.1961349006672855 0.7044938823009019 0.8765083300998372 0.8908864699872939 1.0 15.602307020229189 -7.251564670226031 24.991019648509265 0.8576811948616958 1.1138253121737993 0.3227727230297981 0.1688261486703234 841.5800395493358 2129883.0605758177 0.0698937023133207 0.053471358218448964 5.603189747824407e-08 7.251564670226031 0.2561441173121035 S(ph)LESLR ddPTM_A459_Selumetinib_30min_R2 1 SLESLR 6 0 Q5VT97-2;Q5VT97 Q5VT97-2 SYDE2 Rho GTPase-activating protein SYDE2 1 S(0.999)LES(0.001)LR 96.19 0.044118 0.0 3076.9 3306.4 4890.1 4834.9 4801.2 3621.3 4318.2 4874.3 3479.6 4964.3 True False 2905.8982158066124 3559.990248248337 4575.476289938313 4176.378279332293 4198.030332727411 4120.101204111596 4519.004856350973 4888.483406016194 4175.617228147232 4820.967760199588 0.6027624245482007 0.7384389245741302 0.949078383745277 0.8662945879479166 0.8707858134594978 0.8546211899871788 0.9373646705664519 1.0140045835556075 0.8661367252068828 1.0 12.235107066531555 -5.022028313968081 2.6579793803949494 0.9153058723390906 0.5992619204056074 0.7796671317336933 0.05502531843092431 0.14415873239511723 1.828817750116783 0.014989641300419692 0.07955551997112413 9.50542820691976e-06 5.022028313968081 -0.3160439519334831 S(ph)LEVIPEKANDETGE ddPTM_A459_Selumetinib_30min_R1 1 SLEVIPEKANDETGE 15 1 Q9UPR0;Q9UPR0-3 Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 1 S(1)LEVIPEKANDETGE 136.33 0.0019279 6730000.0 1234.3 933.92 1641.3 1577.5 1234.1 1524.2 1045.3 1269.5 669.48 898.67 True False 1263.0567884702846 824.5762122323706 1418.420475015557 1302.0192383424508 1122.4758728980516 1508.8679318628713 966.4521794241415 1235.82873608284 1136.058663115422 1014.0230482870818 1.245589822247017 0.8131730473239928 1.3988049654409687 1.284013455652572 1.1069530172851314 1.4880016133870886 0.953086994478776 1.2187383099136049 1.1203479694416083 1.0 9.98587472918438 -8.767381372879031 0.9017230894629132 1.0008418706400695 1.1930777942097777 0.08945448125672317 0.18693407929675884 2.5433390164521605 4.056789548122771 0.1780918593508299 0.060064493095129526 1.7085143353802073e-09 8.767381372879031 0.1922359235697082 S(ph)LGDEGLNR ddPTM_A459_Selumetinib_30min_R2 4 SLGDEGLNR 9 0 Q01970-2;Q01970 Q01970-2 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 1 S(1)LGDEGLNR;S(1)LGDEGLNR;S(1)LGDEGLNR;S(1)LGDEGLNR 138.76 0.0024384 35978100.0 185753.0 87998.0 125066.0 151210.0 142326.0 79504.0 183683.0 209752.0 125820.0 84334.0 True False 175429.59188817508 94747.16364183326 117019.38972156477 130614.93714820096 124445.73546941628 90454.95433454508 192224.6234609595 210362.34359368694 150987.5157045305 81899.05829395309 2.142022088441128 1.1568773269866621 1.4288246062800547 1.5948283151119547 1.519501421161085 1.1044687963307596 2.3470919869557543 2.568556317688683 1.8435806082483182 1.0 16.321559242863174 -7.267257753019567 24.973502968091363 2.070520250317038 1.4790726960932994 0.15699139641064175 0.4715130789776406 647.4620793536358 2779010.0545675904 0.18506937688568625 0.12858227511440498 5.404334814144027e-08 7.267257753019567 -0.5914475542237385 S(ph)LGEISALTSK ddPTM_A459_Selumetinib_30min_R2 2 SLGEISALTSK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 S(1)LGEISALTSK;S(1)LGEISALTSK 96.734 0.019938 6471700.0 32989.0 28098.0 34546.0 33907.0 38492.0 26481.1 36560.0 40467.0 32909.0 32349.0 True False 31155.603445430224 30253.02625069008 32323.347970840852 29288.80810716248 33656.29083715395 30128.63115350829 38260.11244226564 40584.75227032751 39491.719554287076 31415.000317204136 0.9917428976872601 0.9630121262205523 1.0289144562936474 0.932319204565557 1.071344596444979 0.9590523905552413 1.2178931101685473 1.2918908757133338 1.2570975379764615 1.0 14.939165974200675 -7.2664355057138295 24.72749190790267 1.2160446381707488 0.9924885159009601 0.5835259009563889 0.08201802464678187 224.53103377194194 1111271.5129971548 0.03163302654680107 0.022077177238927506 5.414576503130438e-08 7.2664355057138295 -0.22355612226978872 S(ph)LGEQDQMTLRPPEK ddPTM_A459_Selumetinib_30min_R2 1 SLGEQDQMTLRPPEK 15 1 P48681 P48681 NES Nestin 1 S(1)LGEQDQMTLRPPEK 65.105 0.036839 14930000.0 45370.0 42007.0 42995.0 54796.0 46104.0 48981.0 53726.0 44385.0 38825.0 46909.0 True False 42848.51703050019 45228.80182620608 40228.7485094165 47332.69027162756 40312.00334501052 55727.688144751955 56224.365456049374 44514.15300166768 46591.08486113817 45554.61528578101 0.9405966170868866 0.992847849607971 0.8830883162341868 1.0390317199408232 0.8849158991271985 1.223315964697572 1.2342188624211414 0.977160112590434 1.0227522407741785 1.0 15.475309605093846 -6.7471552251092355 24.99736748498547 1.0989825568417764 0.9520227296265449 0.38132237839856153 0.0910055643581299 264.23647907139076 462414.867968305 0.03143499092081608 0.03129227654952482 1.789965971800965e-07 6.7471552251092355 -0.1469598272152315 S(ph)LGGAVGSVASGAR ddPTM_A459_Selumetinib_30min_R2 3 SLGGAVGSVASGAR 14 0 Q8NHG8 Q8NHG8 ZNRF2 E3 ubiquitin-protein ligase ZNRF2 1 S(1)LGGAVGSVASGAR;S(1)LGGAVGSVASGAR;S(1)LGGAVGSVASGAR 127.05 0.0012479 12781500.0 93282.3 90200.3 101152.7 98537.5 108527.6 87425.0 86698.8 91070.3 62673.5 88582.5 True False 88098.0432046337 97118.37297032241 94644.64540873241 85116.52251333126 94893.39263894601 99467.00018486634 90730.465990413 91335.29949550022 75209.95124390328 86024.8930600244 1.024099421351942 1.1289566254102457 1.100200674968506 0.9894406082427871 1.1030922476443366 1.1562583415879706 1.0547001311248971 1.0617310437313818 0.8742812524210297 1.0 16.392466573057845 -8.144621816689309 5.827403130157756 0.9387185065582764 1.080898172399643 0.5199874349031772 0.05399346344078907 0.17030217552484855 7.315063883923576 0.03737957877773441 0.013700016249143833 7.167672989615019e-09 8.144621816689309 0.14217966584136654 S(ph)LGPGAGPR ddPTM_A459_Selumetinib_30min_R1 1 SLGPGAGPR 9 0 H3BUV2;P78549-3;P78549-2;P78549 H3BUV2 NTHL1 Endonuclease III-like protein 1 1 S(1)LGPGAGPR 90.149 0.028927 8009100.0 1512.6 1700.5 1368.5 1648.6 1887.9 1221.3 1458.9 1406.8 664.79 1238.6 True False 1547.8406369927518 1501.4046694589972 1182.665216632419 1360.7029580547483 1717.1397783358173 1209.014830851676 1348.853998432871 1369.4870940695857 1128.1000756594701 1397.5863749856787 1.107509821715751 1.074283991552495 0.8462197670212247 0.9736092039883342 1.2286466218257266 0.8650734240766084 0.9651310449035345 0.9798944226854094 0.8071773565129596 1.0 10.448721733321033 S(ph)LGPGAGPR ddPTM_A459_Selumetinib_30min_R2 2 SLGPGAGPR 9 0 H3BUV2;P78549-3;P78549-2;P78549 H3BUV2 NTHL1 Endonuclease III-like protein 1 1 S(1)LGPGAGPR;S(1)LGPGAGPR 109.79 0.011227 21808000.0 16362.0 15068.800000000001 22485.0 19464.0 25386.0 18775.199999999997 20858.2 18833.0 23684.0 21251.3 True False 15452.6655422756 16224.528506171227 21038.339579816948 16812.969622727192 22196.78372628052 21361.313375703765 21828.14762973922 18887.800912029004 28421.461786251035 20637.719751491553 0.7487583768143177 0.78615897015457 1.0194120199881307 0.8146718641972094 1.0755443912196883 1.03506170414781 1.057682141853953 0.9152077428837032 1.3771609522993413 1.0 14.332995956660081 -4.66379457233577 0.40607564228543847 1.1072668993351384 0.4307957494518602 0.4614010938565303 0.12719355572569963 5.584100472669289 0.6751337496740599 0.0984602051665975 1.881461921132232 2.1687297032198396e-05 4.66379457233577 -0.6764711498832783 S(ph)LGPSLATDKS ddPTM_A459_Selumetinib_30min_R2 2 SLGPSLATDKS 11 1 Q9H3N1 Q9H3N1 TMX1 Thioredoxin-related transmembrane protein 1 1 S(1)LGPSLATDKS;S(0.997)LGPS(0.003)LATDKS 106.79 0.019611 40893000.0 103131.0 31500.0 75325.0 80723.0 44059.0 42750.0 144250.0 100118.0 88938.0 50949.0 True False 97399.39188610348 33915.948711535966 70478.67150765916 69728.38814505795 38523.914527542474 48638.42445413822 150957.91082595233 100409.32680457283 106728.08513534846 49477.9699886004 1.9685405829815583 0.6854757525288551 1.4244454961247859 1.4092815077320915 0.7786074193508401 0.9830319325013616 3.051012619570541 2.029374423156546 2.1570829433773926 1.0 15.594498689333047 -7.228898118732471 24.985300854384 2.145149067840422 1.183907102166933 0.3391971511238314 0.5764422504958695 633.0778163264984 486080.1846665905 0.2091175194403602 0.16196923826743295 5.903395518545625e-08 7.228898118732471 -0.9612419656734892 S(ph)LGSVQAPSYGAR ddPTM_A459_Selumetinib_30min_R1 2 SLGSVQAPSYGAR 13 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.999)LGS(0.001)VQAPSYGAR;S(0.886)LGS(0.072)VQAPS(0.042)Y(0.001)GAR 134.4 0.0012257 530810000.0 1829.67 3143.1 2215.3 2530.4 2363.68 2509.8 3140.2 2373.45 1600.1399999999999 2081.9 True False 1872.2977510819296 2775.104390812453 1914.4744277718653 2088.5131414907996 2149.885561341597 2484.553690716071 2903.3321858104746 2310.4983959478664 2715.3207103983887 2349.1321444232885 0.7970167857634839 1.1813317515578676 0.814970938232114 0.8890573254675416 0.9151828969882806 1.057647479140016 1.2359169290253964 0.9835540335322828 1.1558824891330237 1.0 11.197912155416182 -6.841704958308721 4.715984994734211 1.0988932588333347 0.9265217079662501 0.3317587005473215 0.11882111001328763 0.2522926096411307 10.15099461754882 0.04122275395493366 0.03663405276555727 1.43977637054206e-07 6.841704958308721 -0.17237155086708456 S(ph)LGSVQAPSYGAR ddPTM_A459_Selumetinib_30min_R2 7 SLGSVQAPSYGAR 13 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.968)LGS(0.031)VQAPSYGAR;S(0.742)LGS(0.256)VQAPS(0.002)YGAR;S(0.981)LGS(0.018)VQAPS(0.001)YGAR;S(1)LGSVQAPSYGAR;S(0.527)LGS(0.473)VQAPSYGAR;S(1)LGSVQAPSYGAR;S(1)LGSVQAPSYGAR 184.0 0.00010612 2059629000.0 381373.6 318093.89999999997 325699.30000000005 383793.2 329512.5 293437.10000000003 287077.5 256222.0 231439.8 310350.0 True False 360178.3820714821 342490.67929690355 304744.1616325856 331519.9040798025 288116.1938708741 333855.39696822007 300427.1725832744 256967.56360016458 277734.2269683146 301389.389113861 1.1950599293839483 1.1363727180438823 1.0111310239839173 1.0999720496283252 0.9559599782792205 1.1077211375948401 0.9968073974554457 0.8526098558270263 0.9215129563283669 1.0 18.20126909992502 -3.4775428543014137 0.31240065644404796 0.9310634917780455 1.7224328186095512 0.5749337473035971 0.06536665355247437 12.533359702648244 0.5224458961773389 0.069738152712242 4.400842466485424 0.0003330099007105167 3.4775428543014137 0.7913693268315057 S(ph)LHGPCPVTTFGPK ddPTM_A459_Selumetinib_30min_R1 1 SLHGPCPVTTFGPK 14 0 O95544;O95544-2 O95544 NADK NAD kinase 1 S(1)LHGPCPVTTFGPK 89.26 0.031424 0.0 701.29 794.85 1176.6 761.76 751.0 975.15 728.3 994.81 429.8 798.4 True False 717.6286925272026 701.7885924842597 1016.8241826011717 628.7329160061777 683.0721825998191 965.340876365359 673.3637446423057 968.4244072017096 729.3392086500096 900.882417074573 0.7965841922606853 0.7790013204644077 1.1286980002374731 0.6979078557752921 0.7582256792378665 1.0715503578148426 0.7474490920012774 1.0749731472687247 0.8095831318568587 1.0 9.815195007940767 -6.736662952856326 24.998188321347214 0.9333182563219785 0.8381588389278259 0.12191212206896396 0.14463028581334422 585.1510686336042 590387.08160571 0.04668660262036996 0.04666688756281106 1.833736996394974e-07 6.736662952856326 -0.09515941739415257 S(ph)LHLSPQEQSASYQDR ddPTM_A459_Selumetinib_30min_R2 1 SLHLSPQEQSASYQDR 16 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 S(0.924)LHLS(0.076)PQEQSASYQDR 183.75 8.5442e-07 12646000.0 13119.0 12847.0 17181.0 24607.0 27433.0 19932.0 16727.0 17786.0 18695.0 18129.0 True False 12389.898499517998 13832.323590384216 16075.5931652584 21255.48415055734 23986.62128586835 22677.452075318917 17504.83864392171 17837.75431536919 22434.522381944054 17605.568665201205 0.7037488385142373 0.7856788868015888 0.9130970700783485 1.2073159665992772 1.3624451298343916 1.2880840435528045 0.9942785136228746 1.0131881937234393 1.27428558591735 1.0 14.10374420698996 -5.553916069592967 2.8641884856243163 1.1696661509453363 0.7490419220043623 0.6552729928283523 0.12380589801451837 0.17011853717530354 2.816936835735587 0.03808153713127024 0.08043342484450487 2.7930835717662576e-06 5.553916069592967 -0.42062422894097407 S(ph)LIAQDHR ddPTM_A459_Selumetinib_30min_R1 2 SLIAQDHR 8 0 O15013-7;O15013-4;O15013-5;O15013-6;O15013;E9PB39;H0YAN8 O15013-7 ARHGEF10 Rho guanine nucleotide exchange factor 10 1 S(1)LIAQDHR;S(1)LIAQDHR 117.14 0.0059589 8034600.0 2721.1000000000004 2504.2 2442.8999999999996 2324.7599999999998 2376.7 2260.7 2902.7 2385.0 1224.8200000000002 2399.1000000000004 True False 2784.496335661097 2211.0070998290043 2111.167597889175 1918.7843071499176 2161.727904640466 2237.959410551369 2683.7470020228234 2321.7420524281797 2078.4300826866097 2707.047854212935 1.0286099417591124 0.8167595177115357 0.7798781963176598 0.7088106344938618 0.7985554822299147 0.8267158657976691 0.9913925229826105 0.8576656850801104 0.7677847583861447 1.0 11.402504675881554 -7.0333817278552875 24.569560509343603 0.8947359409689429 0.8164280217090356 0.12392870198838168 0.09806728309153089 1175.321427143744 865054.3222812243 0.038521118807406815 0.029861839668517073 9.260155341488329e-08 7.0333817278552875 -0.07830791925990732 S(ph)LIAQDHR ddPTM_A459_Selumetinib_30min_R2 4 SLIAQDHR 8 0 O15013-7;O15013-4;O15013-5;O15013-6;O15013;E9PB39;H0YAN8 O15013-7 ARHGEF10 Rho guanine nucleotide exchange factor 10 1 S(1)LIAQDHR;S(1)LIAQDHR;S(1)LIAQDHR;S(1)LIAQDHR 101.71 0.01112 25957400.0 61408.4 50529.7 62081.9 76465.5 81334.7 38608.4 57481.2 70919.9 51520.4 50081.3 True False 57995.56696530232 54405.16551140635 58087.61814366195 66050.76698965505 71116.70784455631 43926.356647839806 60154.189696837006 71126.26516757855 61825.91960025193 48635.32274215577 1.1924577384377744 1.1186348202075245 1.1943504199945032 1.358082218140686 1.4622439789612889 0.9031780642377776 1.2368415856053732 1.4624404888739073 1.2712143379417304 1.0 15.56971687105387 -5.531803553726842 24.112904831799703 1.2576591932198047 1.1557828304455584 0.03547146129385603 0.17007714910494667 385.66680839144465 1041983.3660060707 0.04716812065812135 0.08187281997363169 2.9389787521195296e-06 5.531803553726842 -0.10187636277424628 S(ph)LIVEGK ddPTM_A459_Selumetinib_30min_R1 4 SLIVEGK 7 0 D6R9L5;H0Y8X0;A0A494C198;B4DFG0;H0Y993;P35659;A0A494C028 D6R9L5 DEK Protein DEK 1 S(1)LIVEGK;S(1)LIVEGK;S(1)LIVEGK;S(1)LIVEGK 113.62 0.014058 42920000.0 25321.1 30214.100000000002 16333.2 15147.3 21629.4 18966.300000000003 29367.5 30322.8 16115.900000000001 31616.2 True False 25911.032363716233 26676.619125845988 14115.24115184554 12502.1084050362 19673.024588980734 18775.516242022553 27152.285831090092 29518.54084166423 27347.50524123477 35674.44723786712 0.7263190986800384 0.747779466573759 0.39566811106361666 0.3504499543237679 0.5514598294349614 0.5263015322096717 0.7611130075834486 0.8274421365198164 0.7665852552357529 1.0 15.12260345540701 -7.403602385785976 2.7086851471186795 0.847217568622161 0.5412095646267905 0.5538440448671009 0.12889708133461075 0.24967309745485544 3.549441739713516 0.07012729195555627 0.042508576551530265 3.948186091056785e-08 7.403602385785976 -0.30600800399537054 S(ph)LIVEGK ddPTM_A459_Selumetinib_30min_R2 4 SLIVEGK 7 0 D6R9L5;H0Y8X0;A0A494C198;B4DFG0;H0Y993;P35659;A0A494C028 D6R9L5 DEK Protein DEK 1 S(1)LIVEGK;S(1)LIVEGK;S(1)LIVEGK;S(1)LIVEGK 84.213 0.037849 67428300.0 225325.0 159248.0 208412.0 245364.0 227088.0 250647.0 307061.0 301833.0 263056.0 193110.0 True False 212802.33854744228 171461.80953697365 195002.99882182883 211944.9999234916 198559.1752475217 285171.34910307307 321339.94492982834 302711.2840588572 315674.55039875256 187534.41253996416 1.13473754318074 0.9142951803602158 1.039825150918758 1.1301659095677998 1.058787944880293 1.5206347743900186 1.713498555159042 1.6141639284168632 1.6832886621887668 1.0 17.516795828687364 -6.773444252883535 5.377091535546615 1.5616878004908927 1.0486309730493824 0.5596778244382181 0.19711813088628313 0.1125168270608161 9.638329650751544 0.0650022417796609 0.06004429583044021 1.6848286816811056e-07 6.773444252883535 -0.5130568274415104 S(ph)LIYTDTLVR ddPTM_A459_Selumetinib_30min_R1 3 SLIYTDTLVR 10 0 Q5SYE7-2 Q5SYE7-2 NHSL1 NHS-like protein 1 1 S(0.995)LIY(0.001)T(0.004)DTLVR;S(1)LIYTDTLVR;S(1)LIYTDTLVR 143.97 0.0010313 24715600.0 4788.639999999999 4798.64 5883.05 6245.959999999999 4774.35 4441.6900000000005 4859.13 4736.0 2449.83 4006.9700000000003 True False 4900.205994928578 4236.812997972786 5084.164123280488 5155.220337190119 4342.510885479957 4397.0106313318465 4492.601911991991 4610.385895303921 4157.182581496172 4521.3036306930135 1.0838037865148833 0.9370777421828179 1.1244907527922872 1.1402066214252327 0.9604554881031843 0.9725094774618984 0.9936518931163614 1.0197027830659657 0.9194654730275149 1.0 12.14252309057072 -6.288286167255367 24.90693483737604 0.9791609686062622 1.0655932433285078 0.39470581530015747 0.05668290447151779 831.2553726533591 771189.4123077716 0.018226259590086998 0.020671560874103666 5.148892596540434e-07 6.288286167255367 0.08643227472224557 S(ph)LIYTDTLVR ddPTM_A459_Selumetinib_30min_R2 2 SLIYTDTLVR 10 0 Q5SYE7-2 Q5SYE7-2 NHSL1 NHS-like protein 1 1 S(1)LIYTDTLVR;S(0.999)LIYT(0.001)DTLVR 139.76 0.0014922000000000002 15570000.0 22185.8 18266.9 24921.0 25552.0 21455.0 18306.6 24833.0 22106.9 22640.1 23771.0 True False 20952.802052794144 19667.912492658936 23317.609991933212 22071.773520341412 18759.631089866416 20828.167979231042 25987.78370565597 22171.227419005703 27168.752617248 23084.669465524737 0.9076500785114389 0.8519902146327684 1.0100907022626577 0.9561225710120731 0.8126445612696578 0.9022510809754667 1.1257594025535786 0.960430793783589 1.1769175494508397 1.0 14.494647455065937 -7.247485870321084 24.657589942088233 1.0624795007682095 0.9069588835651157 0.5179821989575837 0.07510703776340857 543.2535638917095 959998.4445427255 0.028330090610837955 0.021821618801300416 5.656061586662936e-08 7.247485870321084 -0.15552061720309385 S(ph)LLAGLSLPSR ddPTM_A459_Selumetinib_30min_R2 1 SLLAGLSLPSR 11 0 Q8N201;H7C582 Q8N201 INTS1 Integrator complex subunit 1 1 S(0.999)LLAGLS(0.001)LPSR 88.075 0.02061 2473500.0 613.16 3579.3 31736.0 26631.0 67979.0 27455.0 3414.7 9720.2 36643.0 24276.0 True False 579.0830218739583 3853.82080073653 29694.140311544194 23003.81185896259 59438.870280029274 31236.677038324342 3573.490316099684 9748.484172734263 43972.6238909642 23575.088803377173 0.024563344244582595 0.16347004386191172 1.2595558200947456 0.9757677712614703 2.52125753483968 1.3249866118786213 0.1515790818818793 0.4135078452530696 1.8652156205097747 1.0 14.524975584848573 -5.23701744969152 6.266112308884618 1.176572489909895 0.08032829635786778 0.32277822304549997 0.6343776108236854 0.2293292561621618 33.88425936547179 0.17633463074837147 0.45393511139635934 5.794054157974679e-06 5.23701744969152 -1.0962441935520273 S(ph)LLDASEEAIK ddPTM_A459_Selumetinib_30min_R1 1 SLLDASEEAIK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 S(1)LLDASEEAIK 216.68 1.9258e-05 7864700.0 2090.0 2212.5 1250.5 1485.6 1674.6 1381.8 1479.7 1965.6 1472.7 1820.8 True False 2138.6929335679297 1953.4594714366551 1080.6889685048156 1226.167848165797 1523.1327256746433 1367.9003465740168 1368.0850376866956 1913.465902831375 2499.0643382477197 2054.5174160939164 1.040970943743105 0.9508118335402606 0.5260062338918694 0.5968155044881578 0.7413579041692668 0.6658012902975008 0.6658911854287038 0.93134567166108 1.216375348620302 1.0 11.004583844910089 -7.978809268175267 4.276765013120008 1.103884256831121 0.7337337159322815 0.4798981564773357 0.15399761738027076 0.18045936756982559 7.701028514314722 0.1059020878163342 0.044118644624570894 1.0500034639975385e-08 7.978809268175267 -0.37015054089883936 S(ph)LLDASEEAIK ddPTM_A459_Selumetinib_30min_R2 2 SLLDASEEAIK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 S(1)LLDASEEAIK;S(1)LLDASEEAIK 204.32 1.7754e-05 9580800.0 37695.0 33153.0 34710.0 45606.0 44874.0 41421.0 55560.0 51864.0 41493.0 30640.0 True False 35600.06280504088 35695.728496303265 32476.79638939057 39394.38412526181 39236.52694135004 47126.36676759904 58143.650090051415 52014.91565345262 49792.75941128669 29755.343587719388 1.1964258688558287 1.1996409448632812 1.0914609772072799 1.3239431771011592 1.3186380061678644 1.5837950796524833 1.9540574256399592 1.7480865411656745 1.6734056276142997 1.0 14.860861156381452 -6.673863749782131 2.414278206711658 1.6691678882983103 1.1988423206122252 0.3636037987562184 0.23732888753897013 0.2634022627432125 3.1356366957537776 0.08478614592427437 0.08273926376554472 2.1190258281196696e-07 6.673863749782131 -0.47032556768608513 S(ph)LLDASEEAIKK ddPTM_A459_Selumetinib_30min_R1 4 SLLDASEEAIKK 12 1 P18206;P18206-2 P18206 VCL Vinculin 1 S(1)LLDASEEAIKK;S(1)LLDASEEAIKK;S(1)LLDASEEAIKK;S(1)LLDASEEAIKK 167.73 0.00074967 158860000.0 13550.5 11437.099999999999 10511.9 9604.400000000001 10553.599999999999 10302.1 12030.599999999999 13889.400000000001 8891.2 12165.4 True False 13866.200285316849 10098.039015036455 9084.441717733522 7927.17183691679 9599.02874338941 10198.470227558386 11123.122156108373 13521.007992870425 15087.71701244525 13726.94759103083 1.0101444762837883 0.7356361600472999 0.6617961974058446 0.5774897721687517 0.6992835573774174 0.7429525143828809 0.8103128596029758 0.9849974222750755 1.0991312462140923 1.0 13.74472323410491 -7.721426228985919 2.2240072547898446 1.0526340167740804 0.7256919432112207 0.600474638868145 0.10647703292710103 0.21894554792569484 2.1537696267694435 0.07420900718548534 0.03267152087321796 1.8992134227628787e-08 7.721426228985919 -0.32694207356285976 S(ph)LLDASEEAIKK ddPTM_A459_Selumetinib_30min_R2 4 SLLDASEEAIKK 12 1 P18206;P18206-2 P18206 VCL Vinculin 1 S(0.936)LLDAS(0.064)EEAIKK;S(1)LLDASEEAIKK;S(1)LLDASEEAIKK;S(1)LLDASEEAIKK 111.66 0.0034417 115326400.0 73927.0 65205.0 80215.0 95050.0 82455.0 76622.0 84309.0 81849.0 63104.0 71769.0 True False 69818.43329322874 70206.01383287937 75054.05423148841 82104.0260296045 72096.26574294729 87175.98499473644 88229.53555511423 82087.16703916853 75726.56327307833 69696.84249174385 1.00174456685752 1.0073055151845054 1.0768644826396427 1.1780164365312586 1.0344265703498357 1.2507881545001573 1.2659043423031067 1.1777745462270033 1.0865135430209587 1.0 16.08880567804362 -5.461389162946433 1.473282848972296 1.1584247701795953 0.9880973511694118 0.292332462179416 0.08200619110522361 0.5536759594256945 2.1797219981030085 0.025913598964746425 0.09413735458982915 3.4562952703836803e-06 5.461389162946433 -0.17032741901018356 S(ph)LLGIDTEDAIQGR ddPTM_A459_Selumetinib_30min_R1 3 SLLGIDTEDAIQGR 14 0 P49454 P49454 CENPF Centromere protein F 1 S(1)LLGIDTEDAIQGR;S(1)LLGIDTEDAIQGR;S(1)LLGIDTEDAIQGR 186.42 7.1053e-05 31108500.0 5477.409999999999 6027.799999999999 6107.200000000001 6769.299999999999 5300.5 5524.200000000001 5736.400000000001 5362.3099999999995 3382.54 4894.599999999999 True False 5605.022995815459 5322.062373751804 5277.875784448305 5587.1688304986055 4821.070710879281 5468.6315635722885 5303.698729597865 5220.084119562327 5739.923329053056 5522.869587441386 1.0148751309574435 0.9636407830186317 0.9556401252801299 1.0116423612832415 0.872928580794675 0.9901793763169003 0.96031576440952 0.9451760605451246 1.0393008993196642 1.0 12.431202345843845 -8.260468759301023 24.998888992690414 1.0196504519423657 0.9632513842512584 0.2452834594002382 0.038801705027883875 114.18899497603414 2941222.772734752 0.028863823330707063 0.009447732212491088 5.489480424171618e-09 8.260468759301023 -0.05639906769110725 S(ph)LLGIDTEDAIQGR ddPTM_A459_Selumetinib_30min_R2 2 SLLGIDTEDAIQGR 14 0 P49454 P49454 CENPF Centromere protein F 1 S(1)LLGIDTEDAIQGR;S(1)LLGIDTEDAIQGR 180.06 7.3322e-05 12056500.0 18295.2 17964.0 17974.6 22626.0 26019.0 16249.5 15513.5 17890.699999999997 19001.800000000003 19075.0 True False 17278.426025488356 19341.781036635937 16818.133805264744 19544.299767972945 22750.260607188728 18487.7211267256 16234.90848941707 17942.758975035173 22802.6909546523 18524.25518719804 0.9327460592007679 1.0441327244294758 0.9078979767503753 1.0550653492119808 1.2281336214214564 0.998027771691588 0.8764135629397333 0.9686089288726311 1.2309639833946495 1.0 14.177127916178389 -5.791758242937427 24.887406678835017 1.0476176794572492 0.9698462556733132 0.12342746326458598 0.10829112504449202 486.6788846631279 399491.1386034295 0.03236567245976649 0.04801290126350255 1.6152574658562508e-06 5.791758242937427 -0.07777142378393598 S(ph)LLGLSNSEPNGSVETK ddPTM_A459_Selumetinib_30min_R2 1 SLLGLSNSEPNGSVETK 17 0 Q13033-2;Q13033;G3V340;G3V3G7 Q13033-2 STRN3 Striatin-3 1 S(0.981)LLGLS(0.002)NS(0.017)EPNGSVETK 210.39 3.4541e-09 3216100.0 14521.0 12401.0 12423.0 15008.0 16971.0 12937.0 15766.0 14768.0 12519.0 12127.0 True False 13713.98095216868 13352.11682450025 11623.717705139705 12963.884509755937 14838.951257335022 14718.954319606697 16499.150239736333 14810.972435025986 15023.149810085986 11776.862000270012 1.164485153333227 1.1337584514613588 0.9869961713802203 1.1007927671614655 1.260008927420123 1.249819715920016 1.4009801795553052 1.2576331823100593 1.275649643321077 1.0 13.52366755711011 -6.2539401056215 5.9342071183419 1.2624574275143514 1.0905333732178846 0.30606257096193656 0.10320713599519511 0.16723897968577767 25.422932175102545 0.030447334984603197 0.03745045390997247 5.572625967779332e-07 6.2539401056215 -0.17192405429646684 S(ph)LLKEEDPAVLISEVLR ddPTM_A459_Selumetinib_30min_R1 1 SLLKEEDPAVLISEVLR 17 1 E9PLD2;Q9H019-3;Q9H019 E9PLD2 MTFR1L Mitochondrial fission regulator 1-like 1 S(1)LLKEEDPAVLISEVLR 82.406 0.007925399999999999 993660.0 381.82 550.45 632.25 557.7 444.7 412.13 508.88 575.08 407.49 495.2 True False 390.7156631076108 486.0030581027376 546.3939227006554 460.30816432556907 404.4769635181616 407.9843463841003 470.4947718983616 559.827010276896 691.4807681079402 558.7637436564735 0.6992502064482942 0.8697827366578943 0.9778621625038308 0.8237974806908112 0.7238783262337669 0.7301553671222591 0.8420280972768709 1.0019028912174306 1.2375190336849429 1.0 9.12609460181777 -7.877286819599534 3.1693580501927774 1.1202762609573695 0.8110267639206361 0.6478577935820427 0.0937770881740952 0.16010861386994032 3.126517650249348 0.06333390442761053 0.026762541136982246 1.326518100625014e-08 7.877286819599534 -0.30924949703673343 S(ph)LLLPSCRSLR ddPTM_A459_Selumetinib_30min_R1 1 SLLLPSCRSLR 11 1 A0AV02-5;A0AV02-3;A0AV02;A0AV02-2 A0AV02-5 SLC12A8 Solute carrier family 12 member 8 1 S(1)LLLPSCRSLR 72.73100000000002 0.032852 15477000.0 1343.0 1850.7 2247.5 2003.4 2658.4 1710.4 1885.5 1657.2 1111.4 1236.3 True False 1374.2892869769048 1634.019183632911 1942.301844633804 1653.543798475604 2417.948189378639 1693.1949289189447 1743.2752169752412 1613.2456726557555 1885.9646265556562 1394.9911475817812 0.9851598623828093 1.171347349741599 1.3923399069598301 1.18534357823132 1.7333071923575682 1.213767508026198 1.2496675839106297 1.1564558495244353 1.3519545481166515 1.0 10.446040251605162 -11.092099713078023 2.7864810562488684 0.9825444314155675 1.2770664454477247 0.15778736182957454 0.1873913697967275 91550836.24853455 93870782.65049179 11886037.2083934 0.046523205666287856 8.089101538260715e-12 11.092099713078023 0.2945220140321573 S(ph)LMWVNK ddPTM_A459_Selumetinib_30min_R1 1 SLMWVNK 7 0 Q96F85 Q96F85 CNRIP1 CB1 cannabinoid receptor-interacting protein 1 1 S(1)LMWVNK 87.181 0.033928 26861000.0 6822.0 8075.6 8512.1 9047.4 7762.9 7418.9 7649.1 6924.8 4921.0 6800.5 True False 6980.939326698766 7130.104997755412 7356.203573618422 7467.441430731848 7060.747065651313 7344.272601822244 7072.122228674259 6741.131809079516 8350.57758438041 7673.410417479499 0.9097570632735437 0.92919635596625 0.9586615563871701 0.9731580906609051 0.9201576198201804 0.9571067103477872 0.9216400327766194 0.878505311500566 1.0882485270641031 1.0 12.905652205133817 -8.264858312849206 24.999943948333545 1.0441242663174795 0.933482286063979 0.6586592701865649 0.032529517364316446 186.04907467172592 1360396.6118623626 0.027043016585186548 0.008084498097557196 5.434275940460115e-09 8.264858312849206 -0.11064198025350047 S(ph)LNANTDITSLAR ddPTM_A459_Selumetinib_30min_R2 1 SLNANTDITSLAR 13 0 Q92845-2;Q92845-3;Q92845 Q92845-2 KIFAP3 Kinesin-associated protein 3 1 S(1)LNANTDITSLAR 74.96600000000002 0.048091 2535300.0 24609.0 25937.0 29459.0 31005.0 23697.0 38861.0 22485.0 17634.0 23072.0 30714.0 True False 23241.33029763234 27926.28449940027 27563.640012534048 26782.06551339171 20719.97100613209 44213.75000496531 23530.597053182235 17685.312020534144 27687.044685542285 29827.20701544432 0.7791990140276339 0.9362688395510929 0.9241106617277905 0.897907252915908 0.6946668186331839 1.4823295383329635 0.7888970979079019 0.5929255129847327 0.9282479808185233 1.0 14.86434127128167 -11.986180831620773 2.0466041154083703 1.9422312944580475 0.8938459973308757 0.020436161455693602 0.22463574954942253 21955435.625823956 1168720.6119320872 96373357.91296984 0.056456555890344755 1.032331473880337e-12 11.986180831620773 -1.0483852971271719 S(ph)LNLQAESVR ddPTM_A459_Selumetinib_30min_R1 2 SLNLQAESVR 10 0 Q12923-3;Q12923;Q12923-4 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 S(1)LNLQAESVR;S(1)LNLQAESVR 150.26 0.00071671 14906400.0 1255.9 1235.78 1420.17 1590.8600000000001 1608.75 1548.85 1400.94 1300.58 793.4000000000001 1098.3600000000001 True False 1285.1600264440008 1091.0943031014644 1227.3187144354126 1313.0461651407115 1463.2388465478818 1533.269975243281 1295.2659678967348 1266.084393520772 1346.34185235672 1239.3452049324003 1.0369669574943807 0.8803796543199421 0.9902960930908321 1.0594676607574653 1.1806547850626443 1.23716134063464 1.045121216221097 1.0215752548054844 1.0863332080509045 1.0 10.275362373737114 -5.780491879929809 3.2264320058379647 1.1017042712855183 0.9553487718231712 0.35178989260552973 0.07604094916372152 0.25495500997721043 5.4818989857940394 0.023270174642165554 0.0396081024311638 1.6577083309847207e-06 5.780491879929809 -0.14635549946234705 S(ph)LNLQAESVR ddPTM_A459_Selumetinib_30min_R2 3 SLNLQAESVR 10 0 Q12923-3;Q12923;Q12923-4 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 S(1)LNLQAESVR;S(1)LNLQAESVR;S(1)LNLQAESVR 149.32 0.00075264 11827300.0 73998.8 62558.4 73305.0 76150.7 83357.4 56984.1 51047.6 63104.9 50381.3 70857.4 True False 69886.24293666695 67356.42812303988 68588.63610844925 65778.84329271545 72885.29818738901 64833.14252484346 53421.41454890042 63288.52481142139 60458.96777113871 68811.56275236528 1.0156177267499238 0.9788533413408724 0.9967603316216159 0.955927182317254 1.059201321290784 0.9421838413721382 0.776343573843106 0.9197367750414295 0.8786164033029542 1.0 16.070363388137835 -7.001135145707631 24.999717201065756 0.8830253152452068 0.9976002978631948 0.4368631766545603 0.05713086461749655 35.663011002039084 785437.9510407862 0.019144610880484747 0.016667071716481813 9.973896433367752e-08 7.001135145707631 0.11457498261798804 S(ph)LNPALDGLTCGLTSHDKR ddPTM_A459_Selumetinib_30min_R1 1 SLNPALDGLTCGLTSHDKR 19 1 A0A0A0MRE6;O94967-2;O94967;O94967-3;O94967-4 A0A0A0MRE6 WDR47 WD repeat-containing protein 47 1 S(1)LNPALDGLTCGLTSHDKR 87.38799999999998 0.0023139 12646000.0 1964.2 2705.2 2762.9 2929.1 2720.8 2240.5 2891.2 2663.5 1505.6 2138.0 True False 2009.9620383321185 2388.473926386638 2387.713355523355 2417.5876710167186 2474.704120396256 2217.9626042112336 2673.1144562815266 2592.8553277326846 2554.893235326792 2412.433125883562 0.8331679816392684 0.9900684502961513 0.9897531790228783 1.002136658246752 1.0258125267161082 0.9193882227922473 1.1080574328055164 1.074788478036274 1.0590524594919304 1.0 11.236273235211359 -3.678282560742848 0.7947946715695179 1.0332902240018929 1.318758511722629e-40 0.5690994507256353 0.049106104252231594 9.796778417109376 1.2529119010385856 0.018651230205555383 13.43979377249168 0.00020975747151836833 3.678282560742848 -1.0332902240018929 S(ph)LPAEEGSSGK ddPTM_A459_Selumetinib_30min_R2 3 SLPAEEGSSGK 11 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 S(1)LPAEEGSSGK;S(1)LPAEEGSSGK;S(1)LPAEEGSSGK 141.37 0.0010095 50988300.0 252125.0 214831.0 253281.0 266279.0 242353.0 200303.0 219411.0 220038.0 173761.0 235139.0 True False 238112.90183634227 231307.84690945977 236985.1762115023 230011.3408431044 211906.44947669067 227892.92008040345 229614.0462546483 220678.2741507479 208518.05528799075 228349.92610550733 1.0427544510188456 1.0129534563658487 1.037815865558919 1.0072757402024708 0.9279900067880071 0.9979986591942547 1.005535890335944 0.9664039656784701 0.9131514025174091 1.0 17.800886797294154 -6.024686764219146 10.024611251075038 0.969910054044953 1.02825148106709 0.48832141141222085 0.029138661231375713 0.44576837162662764 178.1925069040281 0.008700313359794227 0.011550384260448247 9.447420277298452e-07 6.024686764219146 0.05834142702213696 S(ph)LPAGDALYLSFNPPQPSR ddPTM_A459_Selumetinib_30min_R1 2 SLPAGDALYLSFNPPQPSR 19 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF0 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 S(1)LPAGDALYLSFNPPQPSR;S(1)LPAGDALYLSFNPPQPSR 234.51 3.2789999999999997e-24 72943000.0 2083.04 2467.9900000000002 2459.13 2676.5 2656.8 2371.3 2416.3 1900.3400000000001 1007.6399999999999 1981.87 True False 2131.5707791097325 2179.0365834625773 2125.1936530341827 2209.099519127462 2416.4929090961377 2347.446874968134 2234.0365456257105 1849.9368100257302 1709.8914848862166 2236.2623195485776 0.9531845886219741 0.9744100968899069 0.9503328989879793 0.9878534820429301 1.0805945653030287 1.0497189236019506 0.999004690145959 0.8272449944061872 0.7646202638836143 1.0 11.126873714754892 -7.756469754722834 24.869054976234843 0.8469494540118999 1.0010849318131643 0.45484808728357573 0.06711113128092196 90.39737124879574 452374.8067602033 0.03308000632608174 0.01831941753535179 1.751984442228813e-08 7.756469754722834 0.15413547780126435 S(ph)LPAGDALYLSFNPPQPSR ddPTM_A459_Selumetinib_30min_R2 2 SLPAGDALYLSFNPPQPSR 19 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF0 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 S(0.998)LPAGDALY(0.002)LSFNPPQPSR;S(1)LPAGDALYLSFNPPQPSR 126.14 0.00037476 12212600.0 18724.6 17654.5 17083.3 16035.5 21525.7 16210.9 13878.8 18676.6 12955.6 16404.0 True False 17683.96169251275 19008.54338183531 15984.179076890685 13851.43723721958 18821.44912380039 18443.8043271015 14524.19170032047 18730.94581392242 15547.082009709251 15930.37389728947 1.110078257204098 1.1932264430447288 1.003377521453553 0.8694985645990633 1.1814819441873132 1.157775984795918 0.9117294919733014 1.1758007649217488 0.9759395548371005 1.0 13.95949250789635 -6.704240687067382 0.010735900579143766 4.046295040612013e-07 2.1261263956144894 0.05811296342921024 0.1106923121318755 8383.025951964286 33.85866782381898 3248.6697357648236 3453.547343816065 1.9758743022344581e-07 6.704240687067382 2.1261259909849852 S(ph)LPAPQDNDFLSR ddPTM_A459_Selumetinib_30min_R1 4 SLPAPQDNDFLSR 13 0 O43353-2;O43353 O43353-2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1 S(1)LPAPQDNDFLSR;S(1)LPAPQDNDFLSR;S(1)LPAPQDNDFLSR;S(0.999)LPAPQDNDFLS(0.001)R 165.89 0.00034641 45922000.0 12843.95 14881.61 10688.46 12396.37 12734.78 12196.25 12967.740000000002 12081.47 6847.52 10955.18 True False 13143.189045023833 13139.264182927207 9237.02583950818 10231.576688184596 11582.921397508018 12073.566798308984 11989.572931412637 11761.030169454703 11619.74131692675 12361.384065489749 1.0632457478379553 1.0629282379154554 0.747248511216144 0.82770478078979 0.9370246354407007 0.9767164206163381 0.9699215612016193 0.9514331168051723 0.9400032597778835 1.0 13.59355266588456 -6.530028499180933 18.962359089483723 0.963851397193206 0.9173932045210369 0.04431548872089852 0.09037624959095591 34.924466948315285 92607.90856214704 0.032874915735996255 0.0330590156052123 2.95101556939083e-07 6.530028499180933 -0.04645819267216911 S(ph)LPAPQDNDFLSR ddPTM_A459_Selumetinib_30min_R2 2 SLPAPQDNDFLSR 13 0 O43353-2;O43353 O43353-2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1 S(1)LPAPQDNDFLSR;S(1)LPAPQDNDFLSR 150.34 0.00049523 23861000.0 30389.0 30327.0 35874.0 32999.0 31026.0 25505.0 23683.0 28673.0 22558.0 29243.0 True False 28700.101036805605 32652.98338332544 33565.90589665792 28504.47927354987 27128.236504040793 29018.082238661904 24784.306426974224 28756.43368292932 27070.230323182324 28398.67860756132 1.010613959663744 1.1498064341145573 1.1819530887511362 1.0037255489049544 0.9552640416451538 1.0218110018307565 0.8727274521982601 1.0125975958357705 0.9532214754518441 1.0 14.793536182143162 -5.909685029003111 5.852847690740567 0.9686951304597405 1.1167576900386886 0.567032668215192 0.05663499756647038 0.14222423438267429 7.40929806552971 0.01576792554301638 0.023640236273305124 1.231161343819065e-06 5.909685029003111 0.1480625595789481 S(ph)LPEEDVAEIQHAEEFLIKPESK ddPTM_A459_Selumetinib_30min_R1 3 SLPEEDVAEIQHAEEFLIKPESK 23 1 O60832;H7C2Q9;H7C0M1;C9IYT0;O60832-2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 S(1)LPEEDVAEIQHAEEFLIKPESK;S(1)LPEEDVAEIQHAEEFLIKPESK;S(1)LPEEDVAEIQHAEEFLIKPESK 170.49 8.6613e-13 37548000.0 12651.0 14776.2 17217.5 17971.6 15022.3 14610.3 14500.699999999999 12896.5 7591.199999999999 12221.5 True False 12945.743685439184 13046.195634730992 14879.45806895774 14833.197428713282 13663.535617402473 14463.333647091005 13406.900524419458 12554.442926264157 12881.711960688583 13790.248572491091 0.9387607204748627 0.9460449944865865 1.0789840364907861 1.0756294457449211 0.9908114089153268 1.0488087702742785 0.9722015128257848 0.9103855423830336 0.9341174593752526 1.0 13.751360841554941 -7.501998975908523 7.044651192987055 0.9414203677945655 1.0147006965133785 0.2604817268277486 0.04950779510912169 0.22648250852701296 51.18708580923383 0.02325845623603427 0.014820744204038463 3.1477557366824314e-08 7.501998975908523 0.07328032871881296 S(ph)LPEEDVAEIQHAEEFLIKPESK ddPTM_A459_Selumetinib_30min_R2 4 SLPEEDVAEIQHAEEFLIKPESK 23 1 O60832;H7C2Q9;H7C0M1;C9IYT0;O60832-2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 S(1)LPEEDVAEIQHAEEFLIKPESK;S(1)LPEEDVAEIQHAEEFLIKPESK;S(1)LPEEDVAEIQHAEEFLIKPESK;S(1)LPEEDVAEIQHAEEFLIKPESK 153.65 1.1027e-08 36148000.0 123985.0 112912.0 117174.0 139171.0 140060.0 111910.0 125983.0 128096.0 103842.0 136591.0 True False 117094.4100512798 121571.98733069673 109635.15240940511 120215.66971663397 122464.41064771317 127324.58668216635 131841.45913057844 128468.73815256567 124613.30158790248 132647.26292396145 0.8827502917900603 0.9165058113591572 0.8265165069576462 0.9062808162543562 0.923233604284127 0.9598734559276488 0.9939252135655078 0.9684989748051487 0.9394336440951341 1.0 17.017235381388517 -6.510616871876618 1.8198029837127667 0.973170337429261 0.8796654345857985 0.7213443118303895 0.026474515408785357 0.19073654045939095 1.273749294428725 0.01006898490847043 0.01106078876123751 3.085909092836103e-07 6.510616871876618 -0.09350490284346247 S(ph)LPELDR ddPTM_A459_Selumetinib_30min_R2 1 SLPELDR 7 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(1)LPELDR 96.034 0.023406 7825600.0 13796.0 9463.8 11999.0 14232.0 14973.0 10386.0 14985.0 14267.0 11794.0 8514.9 True False 13029.273549763731 10189.643029086797 11226.997403523405 12293.577048430609 13091.95787968165 11816.577225279054 15681.83219221419 14308.514607970996 14153.129551893451 8269.0527126329 1.57566700836947 1.2322624347913214 1.3577126417844159 1.486697143634036 1.5832476021927688 1.429012201993402 1.8964484490776732 1.7303692581511076 1.7115781025644277 1.0 13.013506351052097 -6.231406954542422 1.4907678052080824 1.621346044978488 1.3745441201160595 0.05777047197788421 0.2406842489937144 0.7574601025642779 3.3653172256462063 0.08623479381748222 0.12169213681322479 5.869391049668079e-07 6.231406954542422 -0.24680192486242847 S(ph)LPHLPGTPR ddPTM_A459_Selumetinib_30min_R2 2 SLPHLPGTPR 10 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 S(0.958)LPHLPGT(0.042)PR;S(0.981)LPHLPGT(0.019)PR 102.53 0.010048 4898000.0 16672.1 16194.5 15401.8 14583.7 15158.1 20633.0 18102.699999999997 18197.3 15992.0 16212.400000000001 True False 15745.53142570425 17436.56607647522 14410.864956211917 12597.374901714269 13253.803962866647 23475.008462274487 18944.51141981954 18250.251130274817 19190.84685381381 15744.305887126038 1.0000778401148325 1.1074839501646705 0.9153064644148928 0.8001225961961916 0.8418157051753008 1.491015776152429 1.2032611380670823 1.1591651776276695 1.218907139596797 1.0 13.942542534909418 -6.737138356295928 24.999998417224088 1.223717287185236 0.9342962180984546 0.5134239403558429 0.1368735838010855 194.349218817785 199938.8190083964 0.046736585150632205 0.046714861482370466 1.8317307818468626e-07 6.737138356295928 -0.28942106908678134 S(ph)LPITIEMLK ddPTM_A459_Selumetinib_30min_R2 2 SLPITIEMLK 10 0 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 S(1)LPITIEMLK;S(1)LPITIEMLK 168.85 0.00025321 86180000.0 441690.0 257800.0 342540.0 399040.0 356870.0 329190.0 456930.0 464470.0 356420.0 277070.0 True False 417142.63802516245 277572.4310423483 320501.3493293532 344690.0636176047 312036.8001417209 374532.9344107077 478178.1503896184 465821.53080285253 427713.959206874 269070.2691856856 1.5503111484133982 1.031598295428156 1.1911436752165843 1.2810410628449398 1.1596851673210469 1.3919521303642886 1.7771497082779788 1.7312263157598757 1.5895994771228636 1.0 18.037623464196336 -7.0104316206269015 5.829764583713834 1.586720095710188 1.2332339614309762 0.22540891697029708 0.23501094166732428 0.18675994007921212 23.66929183045731 0.08314240954755137 0.06831779077223796 9.762664828287858e-08 7.0104316206269015 -0.3534861342792117 S(ph)LPIYSPEK ddPTM_A459_Selumetinib_30min_R2 1 SLPIYSPEK 9 0 C9JUP5;C9JYW1;E7EQD9;E9PDF6;O43795-2;O43795;C9K0I9 C9JUP5 MYO1B Unconventional myosin-Ib 1 S(1)LPIYSPEK 106.62 0.013063 1384900.0 17088.0 13901.0 15727.0 17032.0 18217.0 14752.0 15913.0 16846.0 14299.0 17516.0 True False 16138.31736868387 14967.162001240058 14715.141942262895 14712.212218161203 15928.41759795369 16783.954094677138 16652.98603101131 16895.019070994567 17159.199547441447 17010.267567966486 0.9487397716820951 0.8798898630745834 0.8650741020661108 0.8649018693784128 0.9364001791453227 0.98669547834065 0.9789961248094649 0.9932247687162221 1.0087554166258634 1.0 14.054118214021784 -6.587230118013816 2.8019129874931337 0.9930391012268526 0.8874707441401671 0.8140181813791785 0.02339328430382745 0.11492816400340103 1.8324398112843774 0.008630043611170196 0.008850065811900348 2.5868418715977633e-07 6.587230118013816 -0.10556835708668544 S(ph)LPLDQTLPR ddPTM_A459_Selumetinib_30min_R2 2 SLPLDQTLPR 10 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 S(0.999)LPLDQT(0.001)LPR;S(0.996)LPLDQT(0.004)LPR 86.11399999999998 0.035514 2711300.0 16086.099999999999 15182.1 15694.099999999999 13446.1 17286.9 11577.0 10111.7 10263.900000000001 10207.3 10914.3 True False 15192.098959760388 16346.5182518543 14684.358692444084 11614.717984183724 15115.165075153194 13171.62666445751 10581.914085953435 10293.766249719883 12249.045215791257 10599.175800243014 1.4333283310021208 1.5422442801146399 1.3854245810421795 1.0958133163445998 1.4260698529791949 1.242702915084729 0.9983714097572395 0.9711855377928416 1.1556601613788136 1.0 13.371664463665061 -6.2100044422248235 0.4562786272785558 0.9903811173933135 1.5718551831861187 0.6547416206343237 0.11728617447301642 1.002156188344733 0.37973391977954524 0.10904691196865009 0.2749220869075856 6.165886949896954e-07 6.2100044422248235 0.5814740657928053 S(ph)LPLPTPEEK ddPTM_A459_Selumetinib_30min_R1 1 SLPLPTPEEK 10 0 Q5SYE7-2;Q5SYE7;E9PAK2 Q5SYE7-2 NHSL1 NHS-like protein 1 1 S(1)LPLPTPEEK 82.171 0.043285 4105700.0 2546.4 2790.8 2457.5 2879.9 2948.4 2289.8 2540.9 2954.2 1533.3 2086.1 True False 2605.726165568122 2464.0518385922796 2123.7849980812334 2376.9795274183366 2681.7177405822995 2266.7666909720533 2349.237867309674 2875.845019406008 2601.898112198836 2353.8712553347527 1.1069960430769406 1.0468082453565872 0.9022519788488611 1.0098171350838376 1.139279701260009 0.9629951875382785 0.9980315881700932 1.2217511951379105 1.1053697632366093 1.0 11.200819699189042 -7.727850240937801 24.999668820587008 1.1226706349637394 1.0215265816694155 0.1835933651121091 0.08081823461669721 256.12929611402166 190631.50452764347 0.03824994207845552 0.022082145286715038 1.8713273245046692e-08 7.727850240937801 -0.10114405329432397 S(ph)LPSASTSK ddPTM_A459_Selumetinib_30min_R1 1 SLPSASTSK 9 0 C9J0A7;Q9UQN3-2;Q9UQN3 C9J0A7 CHMP2B Charged multivesicular body protein 2b 1 S(0.993)LPS(0.006)AS(0.001)TSK 84.31 0.036665 27482000.0 7552.9 9105.2 9332.8 9584.9 8194.1 8386.0 8111.4 7922.0 5230.6 7582.3 True False 7728.8678746149335 8039.158951107364 8065.457021400829 7911.077145856458 7452.945101785858 8301.644453878782 7499.550567474394 7711.88282571741 8875.946172091068 8555.562062856381 0.9033734800626944 0.9396412406391207 0.942715038725121 0.9246706514119127 0.8711227908850677 0.9703213410045879 0.8765701788352845 0.9013882161171187 1.037447464804869 1.0 13.062646921218878 -8.260425368108164 24.999318228330193 1.0187237408355947 0.917148333714903 0.6525195422527358 0.029912814518497536 51.97886887519026 1281576.7961668356 0.022712464359194596 0.0074255397873313955 5.490028916066793e-09 8.260425368108164 -0.10157540712069169 S(ph)LPSS(ph)PLLTHQSISVR ddPTM_A459_Selumetinib_30min_R2 1 SLPSSPLLTHQSISVR 16 0 J3QQY7;J3KTM5 J3QQY7 TANC2 2 S(0.921)LPS(0.344)S(0.735)PLLTHQSISVR 118.15 0.0071277 1212400.0 5267.2 4561.3 6682.7 7404.1 9437.5 4978.3 3477.4 3891.1 4670.5 6132.9 True False 4974.47011027222 4911.137043108857 6252.7423575736175 6395.648807215087 8251.876877679522 5664.015636492081 3639.1059903373775 3902.4224567937176 5604.730504673427 5955.827241812151 0.8352274013842386 0.8245936028215903 1.049852875798178 1.0738472671462367 1.3855131357317145 0.9510040178345935 0.6110160423709879 0.6552276112707303 0.9410498789028175 1.0 12.54008619153784 -7.012108329187128 24.7798093043685 0.7742234150584846 1.0395956697099702 0.262190180889451 0.18125461001938023 681.1016579818697 1393880.2207059015 0.07144960703722819 0.05845407857615369 9.725046147200792e-08 7.012108329187128 0.2653722546514856 S(ph)LPSTSSTSSTK ddPTM_A459_Selumetinib_30min_R2 1 SLPSTSSTSSTK 12 0 A0A590UJA3;S4R3W2;A0A590UJU2;A0A590UK38;B1AKN5;A0A590UK09;B1AKN8;Q12857-2;Q12857-3;Q12857;Q12857-4;A0A590UK73;B1AKN7 A0A590UJA3 NFIA Nuclear factor 1;Nuclear factor 1 A-type 1 S(0.999)LPS(0.001)TSSTSSTK 81.494 0.038132 2581000.0 10941.0 11785.0 12594.0 11538.0 11654.0 7792.6 10007.0 10462.0 7707.1 11800.0 True False 10332.943020293202 12688.871605252425 11783.715751310421 9966.504495839825 10189.920331918114 8865.9599158203 10472.34532849432 10492.442687922661 9248.73535436646 11459.303339918046 0.9017077839539154 1.1072986925000252 1.0283099593203278 0.8697304015962198 0.8892268604516224 0.7736910048393664 0.9138727737500678 0.9156265766499642 0.8070940335568955 1.0 13.484231718705699 -5.761701784219059 24.998435020533364 0.8750059112465733 1.0219248279294026 0.3897349396019787 0.0746140747509697 6.112533946386473 582433.212639892 0.019800637528300854 0.0315817199929061 1.7310045752990446e-06 5.761701784219059 0.1469189166828293 S(ph)LPTTVPES(ph)PNYR ddPTM_A459_Selumetinib_30min_R1 3 SLPTTVPESPNYR 13 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 2 S(1)LPTTVPES(1)PNYR;S(1)LPTTVPES(1)PNYR;S(1)LPTTVPES(1)PNYR 230.67 7.2995e-12 451115000.0 15428.499999999998 17821.0 17521.0 18959.9 17013.899999999998 15486.599999999999 16021.699999999999 14516.8 8870.2 12608.0 True False 15787.954031364978 15734.50903524186 15141.744435963905 15648.909386401927 15474.995749048008 15330.818864707746 14813.170269855329 14131.767306787995 15052.081546224576 14226.3596123199 1.1097676750482781 1.1060109166378667 1.0643442770033233 1.0999939417284315 1.087769195405886 1.0776347064523375 1.041248124856007 0.9933509128048479 1.0580416885560524 1.0 13.796278916947244 -7.283402993322058 2.3124244454708927 1.0186129065331007 1.0926135171496547 0.7427130879656987 0.01999962559961472 0.15503643995377608 1.6254939421840864 0.00942828879759129 0.006075489677706461 5.207113050820896e-08 7.283402993322058 0.07400061061655405 S(ph)LPTTVPES(ph)PNYR ddPTM_A459_Selumetinib_30min_R2 4 SLPTTVPESPNYR 13 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 2 S(1)LPTTVPES(1)PNYR;S(1)LPTTVPES(1)PNYR;S(1)LPTTVPES(1)PNYR;S(0.999)LPTT(0.001)VPES(1)PNYR 207.66 0.00019528 606151700.0 356391.0 341262.0 375218.0 408268.0 435880.0 348845.0 346011.0 320171.0 319163.0 380606.0 True False 336584.2149662108 367435.6980697208 351076.88238646986 352661.1940984174 381120.857583359 396895.2322503825 362101.19710778934 321102.64460283774 383004.51815931563 369616.91584685235 0.9106298995949408 0.9940987068404756 0.9498398675344599 0.9541262290185323 1.0311239590053645 1.0738015908742464 0.9796661937892013 0.8687444509057153 1.0362202100025377 1.0 18.49567125892323 -4.757118307088156 24.70079601076202 0.9850051875332443 0.910629770444738 0.155074508013335 0.053551313941683686 239.30726246391592 1367758.1386688144 0.013979928198060076 0.1064021495264494 1.749370074068508e-05 4.757118307088156 -0.07437541708850626 S(ph)LPTTVPESPNYR ddPTM_A459_Selumetinib_30min_R1 3 SLPTTVPESPNYR 13 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 1 S(1)LPTTVPESPNYR;S(0.998)LPT(0.002)TVPESPNYR;S(1)LPTTVPESPNYR 263.89 4.4733999999999986e-30 332450000.0 5059.0 5901.32 6811.3099999999995 7227.17 6025.42 5498.5 5865.6 5203.05 3179.19 5095.89 True False 5176.864856899593 5210.390710950763 5886.371513847689 5965.080430282986 5480.421824874302 5443.190082238555 5423.153069578346 5065.048212111714 5394.853231149429 5749.997119672026 0.9003247739356913 0.9061553601696339 1.023717297824219 1.0374058118872984 0.953117316550395 0.9466422276310686 0.9431575280315404 0.8808783911878931 0.9382358145350073 1.0 12.489345518034591 -6.894244043889255 2.4946609651106164 0.9316417181737302 0.9685426365854644 0.03818300885476544 0.04889881805797051 0.7703655153358298 9.743777943263025 0.021122304447891375 0.01802012459889436 1.275721738717678e-07 6.894244043889255 0.03690091841173415 S(ph)LPTTVPESPNYR ddPTM_A459_Selumetinib_30min_R2 4 SLPTTVPESPNYR 13 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 1 S(0.994)LPT(0.003)T(0.003)VPESPNYR;S(0.92)LPT(0.005)T(0.028)VPES(0.047)PNYR;S(0.999)LPT(0.001)TVPESPNYR;S(1)LPTTVPESPNYR 203.29 6.014100000000001e-05 400129000.0 110458.9 105410.2 114944.7 118949.0 121459.0 98381.7 90045.0 85594.7 81821.4 103568.7 True False 104320.03654001131 113494.8233927857 107549.28314432688 102747.94100153001 106200.23456276329 111932.88615484668 94232.2709207826 85843.76640603456 98187.9662809307 100578.4025272009 1.0372011676343587 1.1284214159405805 1.0693079273678139 1.021570619733619 1.0558950221350154 1.1128918668655035 0.9369036349060921 0.8535009927486028 0.9762331058536775 1.0 16.61796101902314 -7.27570263974493 22.487091387046345 0.929451106381179 1.0705026767504962 0.6436272440855234 0.04675386085072297 124.150107717851 195729.8852787831 0.01919803838253411 0.013035996103379357 5.300262272008077e-08 7.27570263974493 0.14105157036931715 S(ph)LPVSICR ddPTM_A459_Selumetinib_30min_R1 2 SLPVSICR 8 0 O94885;A0A087WW74 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 S(1)LPVSICR;S(1)LPVSICR 192.91 0.00025838 33020000.0 2460.07 3482.7 3348.8999999999996 3025.56 2683.8 2722.78 2602.76 2904.8 1578.41 2098.1099999999997 True False 2517.3848445370595 3074.943864936694 2894.137774190943 2497.202742795174 2441.0507638633762 2695.391305286438 2406.431717705901 2827.7552678798224 2678.4464874947917 2367.4228558220593 1.063343981133834 1.2988570492908231 1.2224845118283647 1.0548190563650066 1.0311004465722076 1.1385339541931963 1.0164773529105329 1.1944445247395055 1.1313764589658544 1.0 11.20910169986525 -5.75710975477093 24.975783793720858 1.0867004824231936 1.205291391521573 0.30088649540070733 0.07876972545326982 128.67144016433176 742238.8956610811 0.02124847453611318 0.03522344062975575 1.7494045237696998e-06 5.75710975477093 0.11859090909837944 S(ph)LPVSICR ddPTM_A459_Selumetinib_30min_R2 4 SLPVSICR 8 0 O94885;A0A087WW74 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 S(1)LPVSICR;S(1)LPVSICR;S(1)LPVSICR;S(1)LPVSICR 152.06 0.0010544 38616600.0 53252.8 60445.8 89816.0 71584.0 77476.0 50840.4 57612.7 68371.0 60999.1 68589.0 True False 50293.22256384881 65081.79849611938 84037.336344267 61834.13571071222 67742.77223577208 57843.20361679927 60291.80470739925 68569.94829057158 73200.62445725822 66608.65735437628 0.7550553420747562 0.9770771710630107 1.261657863739324 0.9283198035615355 1.0170265386879365 0.8684036867618815 0.9051646903289216 1.0294449852931384 1.0989656204569755 1.0 16.023422081027846 -4.777398537859829 5.122692427689248 1.0096601826282043 0.7430919662108149 0.3501294598759572 0.10475681039352323 0.18390709857274826 12.873763581829467 0.027367172222720722 0.16926554202614208 1.669557812448734e-05 4.777398537859829 -0.2665682164173895 S(ph)LPVSVPVWGFK ddPTM_A459_Selumetinib_30min_R1 3 SLPVSVPVWGFK 12 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 S(1)LPVSVPVWGFK;S(1)LPVSVPVWGFK;S(1)LPVSVPVWGFK 154.67 0.00043595 20721700.0 6014.6 6866.699999999999 7778.3 7850.6 6958.0 6146.1 6375.6 6443.3 3654.8999999999996 5090.1 True False 6154.728477625677 6062.743571757777 6722.049583143545 6479.640084013472 6328.650128534676 6084.275814212309 5894.683358974993 6272.402753211946 6202.098356665708 5743.46391677265 1.071605666338742 1.0555900863332204 1.1703824870411614 1.1281763371213955 1.1018873314504694 1.059339085676918 1.02632896182402 1.0920940470949307 1.0798532813192587 1.0 12.487705381889471 -6.750496408991898 4.767671470845986 1.0552939071767433 1.1081296967608727 0.3370219449752805 0.03772580628293823 0.2562446758731166 14.911143808941839 0.013810020679662964 0.013068330072357665 1.7762479553146233e-07 6.750496408991898 0.05283578958412938 S(ph)LPVSVPVWGFK ddPTM_A459_Selumetinib_30min_R2 3 SLPVSVPVWGFK 12 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 S(1)LPVSVPVWGFK;S(1)LPVSVPVWGFK;S(1)LPVSVPVWGFK 234.79 1.332e-10 1857623000.0 3934492.0 3429886.0 3692409.0 4013664.0 4272475.0 3730864.0 3199056.0 3866102.0 3248663.0 3720278.0 True False 3715828.6856593937 3692947.2273782636 3454843.4249309516 3466996.0392434066 3735728.4940888816 4244756.650588627 3347818.4428092083 3877351.716752357 3898486.3752283277 3612863.907696917 1.0284994897657558 1.022166160067844 0.9562617118155722 0.959625418454664 1.0340075323983866 1.1749007875844737 0.9266384033112759 1.0732072438410896 1.0790570790454947 1.0 21.784711480505088 -6.509791136673516 24.82244760800752 1.0538980177320763 0.9919824395353268 0.1655462221120655 0.06270167447031416 1021.3386855074318 1937112.9268758683 0.019875928642726713 0.0215245580339113 3.0917819920767427e-07 6.509791136673516 -0.06191557819674942 S(ph)LQEEHVAVAQLR ddPTM_A459_Selumetinib_30min_R1 2 SLQEEHVAVAQLR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(1)LQEEHVAVAQLR;S(1)LQEEHVAVAQLR 145.79 0.00040853 14099100.0 3585.3 4224.2 4758.1 5446.9 4624.0 3733.8 4456.8 3565.0 1944.56 3448.8 True False 3668.8305142206195 3729.6287002226954 4111.976154372462 4495.701165976224 4205.7600164335045 3696.24136201915 4120.619987809733 3470.444619247991 3299.7762949568714 3891.4870741567975 0.942783682511801 0.9584070637137673 1.0566593376809403 1.1552656042035927 1.0807590867675703 0.9498274802364716 1.0588805537026187 0.8918042262802486 0.8479473867125366 1.0 11.926105849782 -7.7661044796629 24.9974130579575 0.9024068151195741 1.0311025807627308 0.3494796244800886 0.07183326550711538 130.3216930743084 698295.912862564 0.040333027092540844 0.020387676559667566 1.7135450247124723e-08 7.7661044796629 0.12869576564315666 S(ph)LQEEHVAVAQLR ddPTM_A459_Selumetinib_30min_R2 3 SLQEEHVAVAQLR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(1)LQEEHVAVAQLR;S(1)LQEEHVAVAQLR;S(1)LQEEHVAVAQLR 145.04 0.00042206 29155200.0 62484.0 88891.0 75929.0 75345.0 71253.0 37137.0 46521.0 50950.0 47309.0 57436.0 True False 59011.389423270266 95708.6538703856 71043.81080524431 65082.88102262531 62301.56113009787 42252.28465387909 48684.318679612676 51098.256064773464 56772.12192390428 55777.673443350235 1.0579750961324033 1.7158954105102766 1.2736962017140945 1.1668267427598207 1.1169623486245537 0.7575124964075813 0.8728280631686473 0.91610590600683 1.0178287909689177 1.0 15.767400138552782 -6.131508704054458 1.579793258224025 0.9115511019358093 1.390594091257667 0.5417369417363931 0.17050598376448756 0.26735701091250136 1.3321546105247761 0.058578183665905774 0.0887994502887568 7.387394571575778e-07 6.131508704054458 0.47904298932185774 S(ph)LQHQEQLEDSK ddPTM_A459_Selumetinib_30min_R2 3 SLQHQEQLEDSK 12 0 I3L419;I3L156;Q9BSJ6-2;Q9BSJ6;I3L427 I3L419 FAM64A Protein FAM64A 1 S(0.999)LQHQEQLEDS(0.001)K;S(1)LQHQEQLEDSK;S(1)LQHQEQLEDSK 115.04 0.003542 22502200.0 123635.0 96516.5 106431.0 121886.5 121253.0 115137.0 157870.0 141032.0 130170.0 125363.0 True False 116763.8616501188 103919.00520053848 99583.34533331111 105285.34843405974 106020.11412442649 130996.07664037698 165211.26781347033 141442.3797708957 156207.63725368556 121743.44445780877 0.9590977335176705 0.8535901515136817 0.8179770646116602 0.8648132875076265 0.8708486489485573 1.0760010711359065 1.3570444679731868 1.1618069490379317 1.2830886948317013 1.0 16.893484563764233 -6.90879058738301 3.524170737590261 1.2152269068280257 0.8682069291009781 0.7338323814288275 0.09298025246786465 0.10947285554244472 2.6738325003334302 0.032807315920984 0.028378012403162102 1.2336995678810335e-07 6.90879058738301 -0.3470199777270476 S(ph)LQLMDNR ddPTM_A459_Selumetinib_30min_R1 2 SLQLMDNR 8 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 S(1)LQLMDNR;S(1)LQLMDNR 105.65 0.014063 139175000.0 5922.799999999999 6712.8 7501.7 7714.200000000001 7534.6 5345.5 6258.799999999999 6180.2 3046.66 4192.9 True False 6060.7897162373865 5926.862255303949 6483.010343888501 6367.0597834683595 6853.096760341677 5291.729123325668 5786.69367701121 6016.281019881186 5169.95950075765 4731.099557304579 1.2810530919561463 1.2527451987674139 1.3702967492787295 1.3457885860038477 1.4485209362717468 1.118498788543882 1.2231181371097648 1.2716454065297254 1.092760665493816 1.0 12.207959804699653 -8.27819971138051 0.6142146895739503 0.9969523532615517 1.3250031800602504 0.6070205747200627 0.08145196904882036 0.5457889298184126 0.4858483350097453 0.0853635920021571 0.03933619475699848 5.2698746921716115e-09 8.27819971138051 0.3280508267986987 S(ph)LQLMDNR ddPTM_A459_Selumetinib_30min_R2 5 SLQLMDNR 8 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 S(1)LQLMDNR;S(1)LQLMDNR;S(1)LQLMDNR;S(1)LQLMDNR;S(1)LQLMDNR 101.56 0.016937999999999998 169965090.0 124918.7 109564.6 135432.3 153447.1 154126.0 125297.9 118736.4 116223.0 107417.4 136202.3 True False 117976.21874317715 117967.85251428456 126718.73326553899 132547.34026898787 134763.31397607792 142556.5483839102 124257.87787171293 116561.18968824652 128903.88149292489 132269.78570292535 0.8919362658388877 0.891873014591839 0.9580323472372301 1.0020983973368331 1.018851835737853 1.0777710693815492 0.9394275284515319 0.8812382137674287 0.9745527355917837 1.0 17.01312401984181 -5.353955404314881 3.2983526824870255 0.9831826841039707 0.8902142291557525 0.36463541132474186 0.04828468638959017 0.30223329258117493 6.197833394487655 0.014846320679509101 0.036462674868212516 4.426338220423395e-06 5.353955404314881 -0.09296845494821815 S(ph)LQLPASPAPDPSPR ddPTM_A459_Selumetinib_30min_R1 2 SLQLPASPAPDPSPR 15 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)LQLPASPAPDPSPR;S(1)LQLPASPAPDPSPR 229.69 7.7206e-14 47399000.0 2500.1400000000003 3780.1 2155.48 2407.8999999999996 2607.71 2399.05 2757.1 2094.36 1257.25 2086.38 True False 2558.3883975744134 3337.5241346791854 1862.7776552041264 1987.405466881006 2371.8430909285944 2374.9177351631174 2549.1297272460565 2038.810769359951 2133.461424093124 2354.187196062183 1.0867395769774788 1.4176970039858414 0.7912614843543323 0.8442002701422012 1.0074997837452961 1.0088058159247533 1.0828067247625641 0.8660359604241508 0.906241197667601 1.0 11.201013327252953 -5.26326661493469 24.999900716382104 0.9403536523095107 1.252218289528605 0.5557402117965 0.11223727500955359 110.24549098529516 1508382.9806225407 0.02940571515371536 0.06666588499329319 5.454229212106212e-06 5.26326661493469 0.3118646372190942 S(ph)LQLPASPAPDPSPR ddPTM_A459_Selumetinib_30min_R2 4 SLQLPASPAPDPSPR 15 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(0.995)LQLPAS(0.005)PAPDPSPR;S(0.975)LQLPAS(0.025)PAPDPSPR;S(1)LQLPASPAPDPSPR;S(1)LQLPASPAPDPSPR 171.15 4.7746000000000013e-05 60173000.0 59786.3 57169.7 60631.9 66528.6 68782.0 64057.0 70302.1 72871.0 59064.7 60055.7 True False 56463.61678952155 61554.4321604412 56730.90956502127 57467.28991176366 60140.990241118234 72880.27029844993 73571.28695096831 73083.04254555653 70879.29040560631 58321.73589755219 0.9681401954274027 1.0554286701714015 0.9727232684684598 0.9853494418052053 1.0311934189812482 1.2496245040866278 1.2614728594533509 1.253101290982388 1.2153151704899985 1.0 15.831746040461203 -6.698130058547491 5.449579239278768 1.2157439560373673 1.0000992591712 0.6187593439737584 0.07527910554697513 0.11777920056654166 6.7597858622559865 0.023916505290816417 0.02360059916001837 2.0038718362522478e-07 6.698130058547491 -0.21564469686616738 S(ph)LQLPASPAPDPSPRPAYK ddPTM_A459_Selumetinib_30min_R1 1 SLQLPASPAPDPSPRPAYK 19 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)LQLPASPAPDPSPRPAYK 130.11 0.0028198 0.0 852.35 533.64 807.96 975.25 856.46 870.64 688.16 600.91 410.69 455.5 True False 872.2080966156096 471.1611807174945 698.2434698065977 804.9408952098105 778.9933442202941 861.8821520778707 636.2515371592052 584.9719147692313 696.9109343891873 513.9678619457266 1.6970090178667867 0.9167133114779221 1.3585352733209028 1.5661307930082402 1.5156460197166053 1.6769183754311916 1.237920859001864 1.1381488184002495 1.3559426298580104 1.0 9.00553434129292 -7.498262766811688 23.56728044229629 1.1858343211246423 1.436030167405871 0.2664061321473371 0.22154966489115474 577.7555473865341 553144.343517706 0.0959523195290451 0.0642661402552844 3.174952506783798e-08 7.498262766811688 0.2501958462812288 S(ph)LQLPASPAPDPSPRPAYK ddPTM_A459_Selumetinib_30min_R2 2 SLQLPASPAPDPSPRPAYK 19 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(0.829)LQLPAS(0.17)PAPDPS(0.001)PRPAYK;S(0.997)LQLPAS(0.003)PAPDPSPRPAYK 77.584 0.004408100000000001 29150000.0 97247.0 120392.0 110485.0 127211.0 113662.0 91856.0 79805.0 68652.0 57764.0 125316.0 True False 91842.40105058512 129625.67927870629 103376.51538697243 109884.64234878475 99382.76340882764 104508.33021425303 83516.0906306074 68851.76595404961 69318.4140610117 121697.80146992939 0.7546759262802187 1.0651439690201456 0.8494526124411211 0.9029303818272874 0.8166356516587062 0.8587528201162801 0.6862580064870244 0.5657601462181087 0.5695946288572827 1.0 16.892943579735125 -7.24001119618535 3.472990900634527 0.6657855983062734 0.8840780456021035 0.252200695231261 0.13660312432955493 0.2676463229980733 6.86865686092824 0.055723251781615316 0.03942427362744888 5.7542510258926614e-08 7.24001119618535 0.21829244729583008 S(ph)LQPLAPR ddPTM_A459_Selumetinib_30min_R2 1 SLQPLAPR 8 0 Q14764 Q14764 MVP Major vault protein 1 S(1)LQPLAPR 84.68700000000003 0.036326 2435000.0 16205.0 17480.0 24602.0 20593.0 23901.0 18065.0 18780.0 13596.0 17167.0 17485.0 True False 15304.390973754802 18820.65979294124 23019.13410463228 17788.19787509357 20898.342702348968 20553.289772257485 19653.307211864038 13635.562109061026 20600.8796860569 16980.162618514165 0.9013100355745591 1.1083910216749222 1.3556486249156166 1.0475870151972733 1.2307504452026066 1.2104295014140438 1.157427502516097 0.8030289470958079 1.2132321785655291 1.0 14.051562655154212 S(ph)LQQLAEER ddPTM_A459_Selumetinib_30min_R1 3 SLQQLAEER 9 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 S(1)LQQLAEER;S(1)LQQLAEER;S(1)LQQLAEER 136.24 0.0026568 19939500.0 1809.3000000000002 2564.96 2346.88 2280.03 2319.09 1803.14 3220.92 2725.37 1337.76 3115.9799999999996 True False 1851.4531697150499 2264.653290782447 2028.1865864890694 1881.865561963829 2109.3287189685952 1785.002048720127 2977.9634112224294 2653.084334350603 2270.081013875377 3515.9463852154654 0.5265874296321468 0.6441091651184732 0.5768536730302779 0.5352372749132532 0.5999319920913215 0.5076875051980458 0.8469877196491814 0.754586118123646 0.6456529096749184 1.0 11.779697355605999 -8.983888813215097 0.31772776693424565 1.0644561155126162 0.537677926884042 0.6812939235209752 0.08504029507467403 1.824743696597144 0.3914349684672764 0.2985904271157121 0.1063027755972442 1.0377940747703127e-09 8.983888813215097 -0.5267781886285742 S(ph)LQQLAEER ddPTM_A459_Selumetinib_30min_R2 2 SLQQLAEER 9 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 S(1)LQQLAEER;S(1)LQQLAEER 133.16 0.00319 34702000.0 18017.3 16246.1 15367.2 19802.0 18975.3 15946.9 19970.2 24361.3 16156.099999999999 17108.3 True False 17015.970594966504 17492.123630555063 14378.491082542287 17104.933439644657 16591.453172665675 18143.440723454896 20898.853870200583 24432.187349769687 19387.771439150896 16614.338926298293 1.0241737977327814 1.0528329600202964 0.8654266141027762 1.0295283800049257 0.9986225299884551 1.0920350670550147 1.257880555037942 1.4705482690675569 1.1669300551262156 1.0 14.020141269827365 -7.082081551550612 2.8256171628990745 1.2630898119248966 0.9930282662455551 0.43487012649155266 0.12000771148911697 0.22112753443251504 3.4456659734007746 0.048736036307590054 0.037236401942447095 8.27786707838385e-08 7.082081551550612 -0.2700615456793415 S(ph)LQTGVGELHGETR ddPTM_A459_Selumetinib_30min_R2 1 SLQTGVGELHGETR 14 0 Q13393-4;Q13393-2;Q13393 Q13393-4 PLD1 Phospholipase D1 1 S(1)LQTGVGELHGETR 130.39 0.0009749 6739500.0 1127.6 0.0 1414.5 1449.9 1079.0 455.03 3138.9 3483.2 1556.7 923.77 True False 1064.932506140445 0.0 1323.4926099911531 1252.421118782992 943.446373617611 517.7062521489247 3284.865069612353 3493.335535325196 1868.0834978321648 897.0983598572965 1.1870855569392036 0.0 1.4753037896554444 1.3960800452050959 1.0516643612721432 0.5770897320905564 3.6616554177346665 3.894038481890535 2.082361958759266 1.0 9.809122363881094 -7.254491175008085 24.99874562034098 2.900683855569757 0.9538508026844014 0.47776351541652806 0.8620503648422203 414.8097509280047 1492435.479289306 0.32698999238732435 0.24764382135031918 5.5655594352421486e-08 7.254491175008085 -1.946833052885356 S(ph)LQTLPTDSSTFDTDTFCPPRPK ddPTM_A459_Selumetinib_30min_R1 1 SLQTLPTDSSTFDTDTFCPPRPK 23 1 B0QY95;Q9NQG6 B0QY95 MIEF1 Mitochondrial dynamics protein MID51 1 S(0.928)LQT(0.036)LPT(0.036)DSSTFDTDTFCPPRPK 153.97 1.1447e-08 17484000.0 927.2 1423.4 929.1 1057.3 1195.7 1141.8 1237.7 1292.0 380.5 1105.0 True False 948.8019559828639 1256.7476662792926 802.9333231809866 872.6624029790643 1087.5491461179815 1130.3145286714525 1144.3392925220132 1257.7319629925391 645.6807093795459 1246.8375136114764 0.7609668025103369 1.0079482310723162 0.643975910586202 0.6999006634404106 0.8722460900040498 0.9065451723516772 0.9177934414304105 1.008737665703935 0.5178547343425093 1.0 10.284057751769662 -6.412845163627967 13.086043679095955 0.8754475706826845 0.7850359556183801 0.07702085342985265 0.15534724020347526 2.5027116139040033 286.4659933125733 0.047776556762911045 0.05417038857415879 3.865047506824348e-07 6.412845163627967 -0.0904116150643044 S(ph)LQTLPTDSSTFDTDTFCPPRPK ddPTM_A459_Selumetinib_30min_R2 1 SLQTLPTDSSTFDTDTFCPPRPK 23 1 B0QY95;Q9NQG6 B0QY95 MIEF1 Mitochondrial dynamics protein MID51 1 S(0.996)LQT(0.004)LPTDSSTFDTDTFCPPRPK 101.73 2.1693e-05 9330600.0 21871.0 18370.0 22260.0 23224.0 25900.0 20900.0 18118.0 22398.0 19169.0 22365.0 True False 20655.497376549913 19778.91993114019 20827.815834855486 20060.851136365396 22646.210451062216 23778.785288689796 18960.522900135908 22463.174471811504 23003.335626610613 21719.264338751447 0.9510219616276981 0.910662517047168 0.9589558610276941 0.9236432147737567 1.0426785225251352 1.0948246182659032 0.872981819476574 1.0342511662207994 1.0591213066810983 1.0 14.406687617461094 -6.254889027847333 24.79687421905607 1.0156814956725708 0.9358906421052385 0.33520994432002216 0.056018613767642264 598.3962052712897 2265273.6010966417 0.017086993542187248 0.021560954526906522 5.560463216459279e-07 6.254889027847333 -0.07979085356733229 S(ph)LQTLPTDSSTFDTDTFCPPRPKPVAR ddPTM_A459_Selumetinib_30min_R1 1 SLQTLPTDSSTFDTDTFCPPRPKPVAR 27 2 B0QY95;Q9NQG6 B0QY95 MIEF1 Mitochondrial dynamics protein MID51 1 S(0.992)LQT(0.007)LPT(0.001)DSSTFDTDTFCPPRPKPVAR 53.895 0.0042703 27981000.0 1993.4 1525.0 2960.2 3036.1 2243.6 2088.7 2004.1 1983.4 1051.2 1540.5 True False 2039.8423415188088 1346.4522910467333 2558.221099214678 2505.9021296554765 2040.6667761397512 2067.6895743878636 1852.9291234898337 1930.7937890088253 1783.809623389695 1738.2381807407053 1.1735114117960421 0.7746074766767449 1.4717321984749858 1.4416333488818265 1.1739857050373694 1.1895317898878341 1.0659811434473587 1.1107763081041446 1.0262170300675195 1.0 10.76341006453022 -7.281377849576882 2.020026997510331 1.0496747582651162 1.2104982037165932 0.1506622276009253 0.17919593474593276 0.7894188608524236 6.288787268586087 0.09966014490857707 0.06256783465332792 5.231450861905508e-08 7.281377849576882 0.16082344545147698 S(ph)LS(ph)S(ph)SAVES(ph)EAT(ph)HQRK ddPTM_A459_Selumetinib_30min_R1 2 SLSSSAVESEATHQRK 16 1 P43351 P43351 RAD52 DNA repair protein RAD52 homolog 5 S(0.705)LS(0.832)S(0.948)S(0.533)AVES(0.988)EAT(0.993)HQRK;S(0.995)LS(0.986)S(0.87)S(0.339)AVES(0.926)EAT(0.884)HQRK 62.055 0.017991 11791400.0 279.44 163.98 382.01 378.12 280.05100000000004 378.83 531.62 271.72 257.46000000000004 406.06000000000006 True False 285.9504083044127 144.7811453677662 330.13514023072736 312.0884401914721 254.72043649702005 375.0193141501193 491.5194753902825 264.5131029290504 436.89081586559246 458.1817563593449 0.6240981975723761 0.31599063768531316 0.720533141375903 0.681145497086763 0.5559375356212278 0.8184946452909344 1.0727609045280087 0.5773104215908519 0.9535316712238227 1.0 8.839776205087125 -5.974017756900532 0.3140042816534085 0.9794265816486704 0.3099047773809041 0.46722732582449367 0.16105302066630053 3.237300509731186 0.459288666616964 0.1944462170313138 0.7873430157633347 1.0616521487793495e-06 5.974017756900532 -0.6695218042677662 S(ph)LSAMDVEK ddPTM_A459_Selumetinib_30min_R1 2 SLSAMDVEK 9 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 S(0.867)LS(0.133)AMDVEK;S(0.988)LS(0.012)AMDVEK 158.08 0.00086805 35494000.0 6377.6 7038.8 5435.6 5796.2 5806.4 4907.9 5963.1 6535.5 3607.7999999999997 5586.2 True False 6526.185671350636 6214.694023750658 4697.475375613573 4784.0024781492975 5281.212145203179 4858.530982016659 5513.298566080645 6362.157309704135 6122.173096713599 6303.243184195863 1.0353694884744027 0.9859518095910967 0.7452473652597705 0.7589747592389008 0.8378563210832123 0.77079859368245 0.874676480816122 1.0093466369274768 0.9712735044181285 1.0 12.62187860880392 -7.695944321838261 5.165552659804947 0.9928114315642955 0.8495033858823604 0.32435003504734017 0.08920304492933272 0.2545808626856061 12.93826110090858 0.04900880889068483 0.027021977254901314 2.0139824333222084e-08 7.695944321838261 -0.14330804568193511 S(ph)LSAMDVEK ddPTM_A459_Selumetinib_30min_R2 3 SLSAMDVEK 9 0 Q6ZV73-2;Q6ZV73;F8VY01 Q6ZV73-2 FGD6 FYVE, RhoGEF and PH domain-containing protein 6 1 S(0.991)LS(0.009)AMDVEK;S(0.983)LS(0.017)AMDVEK;S(0.998)LS(0.002)AMDVEK 143.0 0.0020716 26176100.0 158416.0 141184.0 154531.0 159865.0 164843.0 146676.0 173327.0 172533.0 134051.0 150550.0 True False 149611.8729094933 152012.35882188854 144588.64370063104 138091.1112174928 144133.94862488206 166879.28760784035 181387.0489409347 173035.04246562405 160864.94569788635 146203.23032412407 1.0233144136269252 1.0397332431361876 0.9889565598522442 0.9445147751616215 0.9858465391314916 1.1414199757274766 1.240650076874568 1.1835240718143876 1.1002831150943662 1.0 17.157615662068537 -6.7770860508786255 7.829201241586928 1.1517648455895333 0.9954552387870402 0.5284994343488872 0.06336309986688651 0.11337073918162884 36.60284142417735 0.02205321358206146 0.020085830320097944 1.6707595381021766e-07 6.7770860508786255 -0.15630960680249306 S(ph)LSAPLHPEFEEVYR ddPTM_A459_Selumetinib_30min_R2 1 SLSAPLHPEFEEVYR 15 0 Q53HC0-2;Q53HC0 Q53HC0-2 CCDC92 Coiled-coil domain-containing protein 92 1 S(0.796)LS(0.204)APLHPEFEEVYR 81.643 0.01779 1358100.0 12589.0 8467.1 8990.2 13179.0 11199.0 5413.0 6292.5 9887.6 6624.9 8269.1 True False 11889.353777759903 9116.499343982427 8411.780319789656 11383.997464956929 9792.081499669728 6158.591615678368 6585.113718352203 9916.371279019708 7950.065115172029 8030.349597297995 1.4805524508871148 1.1352555992144966 1.0474986447190295 1.4176216523359517 1.219384209993113 0.7669145086473663 0.8200282738086426 1.2348617154048076 0.9900023677483506 1.0 12.971247080786917 -6.628130924671326 8.545760379801575 0.9687107955550446 1.2536891679172109 0.45144710095605667 0.16433540980519468 0.2721189207749603 20.080649881552183 0.056744775097509255 0.05670314124583027 2.3543394255050486e-07 6.628130924671326 0.2849783723621663 S(ph)LSDIK ddPTM_A459_Selumetinib_30min_R1 1 SLSDIK 6 0 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 S(0.966)LS(0.034)DIK 89.75200000000002 0.047937 5183400.0 2355.9 2740.4 2193.5 2209.9 3483.7 3274.5 3717.5 3337.2 2098.9 3631.9 True False 2410.7878862165976 2419.552694022604 1895.6347480330362 1823.9824499606873 3168.5999500971893 3241.56150300812 3437.085982023579 3248.686615246675 3561.6800024092727 4098.089742701832 0.5882711305944188 0.5904098850767031 0.46256545538294197 0.44508113889134915 0.7731894977995678 0.7909932935902446 0.8387044203081656 0.7927319359055438 0.8691073710018588 1.0 12.000735862455183 -6.392090135694226 4.189488753286427 0.8389793062028585 0.5231758016484912 0.8323898146871727 0.07133970995364884 0.09778753705006485 2.860212196832358 0.023258291813324644 0.026438785598930394 4.054243828694923e-07 6.392090135694226 -0.31580350455436734 S(ph)LSDSESDDSK ddPTM_A459_Selumetinib_30min_R1 3 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.95)LS(0.049)DSESDDSK;S(0.95)LS(0.035)DS(0.014)ES(0.001)DDSK;S(0.665)LS(0.242)DS(0.093)ESDDSK 289.71 8.454e-53 177194000.0 9001.0 11342.7 9801.9 10332.599999999999 8888.9 9504.8 9622.6 8814.2 5718.599999999999 8726.599999999999 True False 9210.705787102843 10014.691410921836 8470.855817982689 8528.205376923743 8084.900564462754 9409.190341667907 8896.7595348003 8580.418783443374 9704.046529981266 9846.744114282274 0.9354062297346709 1.0170561248155074 0.8602697216124547 0.8660939370358931 0.8210734909558539 0.9555636088908095 0.9035229748578454 0.871396543249037 0.9855081453681699 1.0 13.265431052207727 -8.350434837566976 5.9341787826381935 0.997171080752029 0.9039334577693079 0.3135822940689964 0.052713837788804965 0.3159373535197139 16.43288183231859 0.0537570892574066 0.014002123139122592 4.4623657380717715e-09 8.350434837566976 -0.09323762298272109 S(ph)LSDSESDDSK ddPTM_A459_Selumetinib_30min_R2 2 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.601)LS(0.399)DSESDDSK;S(0.844)LS(0.145)DS(0.007)ES(0.004)DDSK 137.4 0.0015257 5374100.0 93492.0 169724.0 97974.0 134271.0 123596.0 90205.0 81862.0 94861.0 84582.0 131446.0 True False 88296.08891812923 182741.28505132464 91670.45950602565 115983.05816960544 108068.76551774066 102629.91995053887 85668.74520647567 95137.02980491599 101500.76341853943 127650.81244227718 0.6917001719676177 1.4315716567331602 0.7181345559197158 0.908596317959607 0.846596770127167 0.8039895554675566 0.6711179002108936 0.7452912205156258 0.7951438888368797 1.0 16.961843194341768 S(ph)LSDSESDDSKSK ddPTM_A459_Selumetinib_30min_R1 1 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.541)LS(0.437)DS(0.021)ES(0.001)DDSKSK 138.55 0.0046615 3109800.0 375.88 339.77 1140.3 718.3 547.51 544.28 463.1 430.83 374.5 358.1 True False 384.6372726648392 299.9895704452123 985.4535232195451 592.8623891609401 497.98781717074144 538.8050373666996 428.16799415605124 419.40298886693165 635.499147602207 404.0656231893847 0.9519178336152603 0.742427846440695 2.4388452436045642 1.4672428316998072 1.2324429216225 1.3334592364324018 1.059649644967124 1.037957610836788 1.5727622225965754 1.0 8.658445805924032 -6.324384380080325 5.694026479416087 1.205087476103486 1.42687082870334 0.04283755103642173 0.4430557992282526 0.8202017189882735 53.972198816817816 0.1461362862200346 0.1671944312321342 4.738224346220674e-07 6.324384380080325 0.22178335259985404 S(ph)LSESSVIMDR ddPTM_A459_Selumetinib_30min_R1 2 SLSESSVIMDR 11 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 S(0.682)LS(0.318)ESSVIMDR;S(0.561)LS(0.439)ESSVIMDR 177.04 6.6993e-05 49223000.0 4685.1 4891.9 5726.9 6051.4 4826.6 4844.700000000001 4820.7 4447.1 2472.1 3901.5 True False 4794.253714382349 4319.154073817389 4949.21843560994 4994.636588846597 4390.034882205442 4795.966716635649 4457.070717832166 4329.148461783379 4194.973144959725 4402.295528828216 1.0890349552835366 0.9811140677706938 1.1242358454129726 1.1345527705124439 0.9972149423993718 1.0894240709714957 1.0124424152456957 0.9833843351574566 0.9529058459363187 1.0 12.104040282155017 -7.504540553961942 2.7043133708516693 0.9755731989968062 1.0676569101644 0.42896348526541395 0.04731478094252902 0.2795966522228177 4.095374692157126 0.025209673402865843 0.014131826251583894 3.129388238937343e-08 7.504540553961942 0.09208371116759384 S(ph)LSGSPLK ddPTM_A459_Selumetinib_30min_R2 1 SLSGSPLK 8 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 S(0.849)LS(0.052)GS(0.099)PLK 99.013 0.018995 68354000.0 278980.0 247590.0 309450.0 237520.0 238680.0 193230.0 226180.0 253150.0 192490.0 237210.0 True False 263475.40844542545 266579.3568726722 289540.3239036851 205169.36625514628 208694.88457372694 219845.67853270468 236697.81816716763 253886.62458876142 230993.378619974 230361.13095440328 1.1437494136004076 1.1572236851252384 1.256897475299318 0.8906422945794472 0.9059466052675142 0.9543523146542461 1.027507623297867 1.1021244058704274 1.0027445935125916 1.0 17.81353778448981 -5.757823975952477 24.999927955170087 0.9849951837053781 1.1830835512903757 0.683950559027465 0.0631041628376338 60.92891757299096 421305.47641410196 0.01964672837590824 0.03238717938084509 1.7465298961226942e-06 5.757823975952477 0.1980883675849976 S(ph)LSGSS(ph)PCPK ddPTM_A459_Selumetinib_30min_R1 3 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.983)LS(0.017)GS(0.028)S(0.972)PCPK;S(0.999)LS(0.001)GS(0.026)S(0.974)PCPK;S(0.998)LS(0.002)GS(0.224)S(0.776)PCPK 155.47 0.0095509 56537000.0 24729.9 28053.1 30429.2 32286.300000000003 26633.0 24489.6 26692.3 26329.9 16147.4 22896.300000000003 True False 25306.05855399117 24768.63001046764 26297.081775631133 26648.103793911807 24224.049852438064 24243.256858777702 24678.87832090598 25631.545520431308 27400.95844056578 25835.263133848388 0.9795161916054235 0.958714060009581 1.0178755153137065 1.031462449437895 0.9376351124018794 0.9383785538849457 0.9552400605733581 0.9921147459438809 1.0606030330949514 1.0 14.657053957330605 -8.047505912952065 7.088585759611462 1.0295662855380885 0.9745398443561863 0.32439244426921265 0.032054362893776354 0.32327634485639284 40.05884015710588 0.02326284397770279 0.008882564283468829 8.96383981531479e-09 8.047505912952065 -0.05502644118190214 S(ph)LSGSSPCPK ddPTM_A459_Selumetinib_30min_R1 1 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.999)LS(0.001)GSSPCPK 103.91 0.013716999999999998 41123000.0 1406.0 1683.1 1850.9 1854.7 1673.3 1449.8 1651.4 1434.2 809.6 1168.1 True False 1438.7570644002428 1486.0418695480387 1599.5579462659432 1530.811462030899 1521.9503104451085 1435.2163283130762 1526.8335684502322 1396.160357061843 1373.8320691555336 1318.037013257525 1.0915907898856032 1.1274659623368923 1.2135910677596526 1.1614328327908658 1.1547098413295787 1.0889044191300388 1.158414788881131 1.0592724961579314 1.0423319340328019 1.0 10.364175169494619 -8.05326310679544 1.077251095621188 1.0001720130685787 1.1484952281759422 0.6629911458562461 0.03581423645928591 0.3027200322747086 0.6559552080162221 0.03431955124401307 0.012134673687178674 8.845795463685844e-09 8.05326310679544 0.14832321510736346 S(ph)LSGSSPCPK ddPTM_A459_Selumetinib_30min_R2 1 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.996)LS(0.004)GSSPCPK 115.29 0.006694299999999999 63794000.0 37479.0 31437.0 40929.0 32222.0 46669.0 30379.0 27054.0 27601.0 29456.0 37637.0 True False 35396.067220324345 33848.116814112924 38295.672700125804 27833.308013949627 40806.02299384642 34563.43149689509 28312.06460648398 27681.31434040846 35348.023069405914 36550.32201733013 0.9684201196241581 0.9260689084507663 1.0477519919514833 0.7615065060371458 1.116434021415693 0.9456395891808296 0.7746050662169262 0.7573480290346968 0.9671056537517192 1.0 15.157596496281437 -7.067906103973539 10.830550504267457 0.855207336779834 0.9628600480402877 0.11940149251725607 0.11057991387509251 1.3424513957491915 210.7314556895164 0.0407989671175966 0.03161855833466065 8.552516013644566e-08 7.067906103973539 0.10765271126045373 S(ph)LSIEIGHEVK ddPTM_A459_Selumetinib_30min_R2 1 SLSIEIGHEVK 11 0 A0A3B3IU16;C9JTT8;Q68DU7;H7C1N3;O15155-2;O15155 A0A3B3IU16 BET1;DKFZp781C0425 BET1 homolog 1 S(0.5)LS(0.5)IEIGHEVK 77.204 0.042598 0.0 30478.0 10386.0 26590.0 24693.0 14017.0 11086.0 33268.0 28170.0 17676.0 16552.0 True False 28784.154773100818 11182.572803746429 24879.228349003017 21329.770802199047 12256.059146430078 12612.995871311736 34815.02791929142 28251.97003620547 21211.693908705176 16074.10075273927 1.7907163340503238 0.6956888584788016 1.547783526538069 1.3269651055636273 0.7624724601991474 0.7846781642924746 2.16590828033465 1.7576081219592272 1.3196193202341588 1.0 13.972450409429142 -7.24725261530925 24.99751573234797 1.6239179895725397 1.138991988739657 0.169784435533877 0.43410944497934695 1215.558900114777 2141855.17527896 0.1641683637942558 0.12653459841743245 5.659100213961044e-08 7.24725261530925 -0.48492600083288284 S(ph)LSLESTDR ddPTM_A459_Selumetinib_30min_R1 2 SLSLESTDR 9 0 H0Y7V8;A0A0A0MRJ1;H0Y5V1;A0A0A0MRJ0;Q5VT25-3;Q5VT25-4;Q5VT25-5;Q5VT25;Q5VT25-2;Q5VT25-6 H0Y7V8 CDC42BPA Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase MRCK alpha 1 S(0.999)LS(0.001)LESTDR;S(0.997)LS(0.003)LESTDR 157.75 2.4592e-05 0.0 2866.1 3106.5 2867.1000000000004 3100.0 3178.9 2752.8 3096.4 2771.1 1694.4099999999999 2203.8 True False 2932.8745535402127 2742.7895358273313 2477.7635678529828 2558.643194207036 2891.369056280378 2725.1093313424176 2862.8360550740595 2697.6014261986284 2875.2900151900017 2486.6791968298403 1.1794342258861568 1.102992914938121 0.9964146444832033 1.0289397995000478 1.1627430912545773 1.0958829489612256 1.1512687518051243 1.0848208444570107 1.1562770215215474 1.0 11.28000468405632 -4.7844651917444505 4.87538506425712 1.088748871388032 1.183849161737504 0.1878420836087601 0.05834024822212829 0.2980872921027177 16.907130072054716 0.014957781436796868 0.09196751552195023 1.642611308003838e-05 4.7844651917444505 0.09510029034947198 S(ph)LSLESTDR ddPTM_A459_Selumetinib_30min_R2 1 SLSLESTDR 9 0 H0Y7V8;A0A0A0MRJ1;H0Y5V1;A0A0A0MRJ0;Q5VT25-3;Q5VT25-4;Q5VT25-5;Q5VT25;Q5VT25-2;Q5VT25-6 H0Y7V8 CDC42BPA Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase MRCK alpha 1 S(0.986)LS(0.013)LESTDR 86.344 0.03397 6465400.0 59414.0 41988.0 53328.0 58177.0 66384.0 43219.0 58891.0 72031.0 56313.0 57825.0 True False 56112.00773308655 45208.34458730073 49896.93453913626 50253.19223907725 58044.24843951016 49172.02494698015 61629.548190302674 72240.59828462602 67577.17351668446 56155.44200260684 0.9992265349898186 0.8050572299867584 0.8885502946770493 0.8948944295860837 1.0336353231235476 0.8756413126388978 1.0974813124512797 1.2864398481855503 1.2033949178700687 1.0 15.777138219980047 -7.412942857360922 4.022779143890121 1.1856135094391091 0.9147659505907294 0.6109003082049238 0.09045365482141966 0.1421852828959309 3.981596078902037 0.039616844194359006 0.025441628641968455 3.8641781693846155e-08 7.412942857360922 -0.27084755884837974 S(ph)LSMVDLQDAR ddPTM_A459_Selumetinib_30min_R1 1 SLSMVDLQDAR 11 0 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 S(0.5)LS(0.5)MVDLQDAR 137.09 0.0013616 8027300.0 1771.4 2031.2 2445.0 2340.8 2281.6 1711.4 2138.4 1839.1 1223.1 1768.1 True False 1812.6701734556123 1793.3861597207394 2112.98242942365 1932.0232222580103 2075.2296828491967 1694.184869826872 1977.098766364282 1790.3210937612844 2075.51136831044 1995.0528577524456 0.9085825302381717 0.8989166140395415 1.0591110011010232 0.9684070348063649 1.0401878199794041 0.8491929741327653 0.9910006938821712 0.8973802808303513 1.040329011958428 1.0 10.962211254972924 -3.604043928648102 0.005806899899516306 1.8855887875607167 8.670958195296303e-06 0.05113398838124916 0.06722675088114893 116297.4845190359 77.37405606385238 11851.326743200232 13308.461009318013 0.00024886055844644176 3.604043928648102 -1.8855801166025214 S(ph)LSMVDLQDAR ddPTM_A459_Selumetinib_30min_R2 1 SLSMVDLQDAR 11 0 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 S(0.619)LS(0.381)MVDLQDAR 139.19 0.0011888 5795900.0 39467.0 37863.0 36916.0 42467.0 40224.0 42061.0 36489.0 48824.0 33211.0 36436.0 True False 37273.58213891891 40766.97035126625 34540.86475110175 36682.92134033885 35170.70151287749 47854.52095825751 38185.81080158181 48966.06975675167 39854.127992872105 35383.9980079029 1.0534022223999102 1.1521301335751004 0.9761719052603146 1.03670934336323 0.9939719504003541 1.3524339716379523 1.0791830474626731 1.3838478553445335 1.1263319646347147 1.0 15.110809445675821 -6.737445913040276 24.999811002267364 1.2055264244019193 1.0445648687696658 0.2742991161106483 0.11696294332878678 271.8873165117417 283290.2655031081 0.03612962175316566 0.036112133403352176 1.8304340540572406e-07 6.737445913040276 -0.16096155563225345 S(ph)LSPGAASSSSGDGDGK ddPTM_A459_Selumetinib_30min_R1 1 SLSPGAASSSSGDGDGK 17 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.606)LS(0.394)PGAASSSSGDGDGK 214.82 6.948300000000001e-10 5477000.0 1117.9 1624.3 1418.5 1753.4 1537.9 1452.9 1564.2 1081.4 878.58 1258.1 True False 1143.944894945258 1434.1262008834165 1225.8754912627594 1447.2016053943921 1398.7972165382976 1438.2851451276524 1446.2111346553559 1052.7177591177497 1490.8860910556677 1419.5893899317643 0.8058280112957482 1.0102401518740225 0.8635423031174414 1.0194508466028722 0.9853533891272136 1.0131698330013488 1.0187531302448458 0.7415649670137017 1.0502234671726662 1.0 10.471257981453077 -4.749853520937235 24.712865783178106 0.9608977709047702 0.8058276128363473 0.22432064965538467 0.08923780698168535 717.0787851056713 1529431.4254637528 0.021553609079390648 0.3314948129342115 1.7788792901770408e-05 4.749853520937235 -0.15507015806842295 S(ph)LSPGGAALGYR ddPTM_A459_Selumetinib_30min_R1 2 SLSPGGAALGYR 12 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 S(0.87)LS(0.13)PGGAALGYR;S(0.925)LS(0.075)PGGAALGYR 190.66 0.00011909 493490000.0 9124.0 9926.099999999999 10437.5 11705.5 10978.900000000001 8648.3 9835.5 8892.3 4582.4 7535.9 True False 9336.571447786508 8763.947597481301 9020.144829083572 9661.354164448527 9985.860433482225 8561.305954028128 9093.60031639352 8656.447317738826 7775.998114745944 8503.206170882106 1.0980060062236443 1.0306638956364558 1.0607933816742727 1.1362013304501914 1.174364143689381 1.0068326913376482 1.0694319452741399 1.0180215725430097 0.9144783695088599 1.0 13.053791202934159 -7.8140450953737774 1.6437311614555215 0.9576961159382179 1.0874163973106963 0.503669629468923 0.04972347866017361 0.33848734924620877 1.7148498771565814 0.041566185275489866 0.015694828999052304 1.5344576426821275e-08 7.8140450953737774 0.12972028137247837 S(ph)LSPGGAALGYR ddPTM_A459_Selumetinib_30min_R2 6 SLSPGGAALGYR 12 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 S(0.913)LS(0.087)PGGAALGYR;S(0.969)LS(0.031)PGGAALGYR;S(0.985)LS(0.015)PGGAALGYR;S(0.999)LS(0.001)PGGAALGYR;S(0.844)LS(0.156)PGGAALGYR;S(0.999)LS(0.001)PGGAALGYR 213.63 2.5312e-06 871893000.0 507356.0 468770.0 555784.0 567483.0 637640.0 406615.0 392652.0 458296.0 372724.0 453008.0 True False 479159.1846269875 504723.1516668802 520025.4625318647 490190.8364372233 557533.9626260739 462622.52536653634 410911.0960251773 459629.5654850128 447279.2147786945 439928.4819838638 1.0891751824437743 1.1472845526864364 1.1820681856896431 1.1142511942548041 1.2673286351269335 1.0515857561218438 0.934040674457284 1.0447824687601646 1.0167089267821043 1.0 18.746909482110603 -6.986497875563172 24.09964146239095 1.0012146451872974 1.1581421366725515 0.6941264938966754 0.050938134749965225 83.6751260030998 149348.82733551806 0.017453769542896964 0.015383587170931334 1.0315781255943486e-07 6.986497875563172 0.1569274914852541 S(ph)LSPGVSR ddPTM_A459_Selumetinib_30min_R1 2 SLSPGVSR 8 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 S(0.925)LS(0.074)PGVSR;S(0.943)LS(0.057)PGVSR 104.42 0.014616999999999996 49639000.0 10920.099999999999 13781.0 9748.3 11538.5 14155.9 9919.1 12272.5 11244.5 5039.9 9919.2 True False 11174.517083184286 12167.51411338691 8424.534403578957 9523.517579470279 12875.501344427137 9819.32285982221 11346.77544435356 10946.259332716421 8552.342200267993 11192.425941190015 0.9983999127535148 1.0871203595467542 0.7526995887973893 0.850889488079803 1.150376282325275 0.8773185466151218 1.0137905315589815 0.9780059649474508 0.7641187214644799 1.0 13.450235151699204 S(ph)LSPIIGK ddPTM_A459_Selumetinib_30min_R1 1 SLSPIIGK 8 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.86)LS(0.14)PIIGK 112.3 0.011233 621350000.0 9751.4 11987.0 12224.0 11857.0 11339.0 8925.6 11957.0 11263.0 5319.0 8979.8 True False 9978.588647078614 10583.55646739489 10564.047941625633 9786.397533455753 10313.389452063044 8835.81656779638 11055.073863364074 10964.268652619943 9025.954515610527 10132.444800659132 0.9848154955089902 1.044521502520933 1.0425961502339913 0.9658476040075867 1.0178579459314836 0.8720320457330887 1.091056904908569 1.0820950785645238 0.8907973044198942 1.0 13.306694695468893 -5.750444520511954 24.82080591753434 0.9925876073302906 1.0260320907956013 0.05141804792027971 0.06806342505215986 734.7880546345832 1658758.2212536563 0.018655856297316174 0.03191752921405321 1.776460189907511e-06 5.750444520511954 0.033444483465310704 S(ph)LSPIIGK ddPTM_A459_Selumetinib_30min_R2 2 SLSPIIGK 8 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.991)LS(0.009)PIIGK;S(0.995)LS(0.005)PIIGK 128.86 0.004222399999999999 1157710000.0 507060.0 354210.0 432810.0 433040.0 370410.0 256390.0 381620.0 354780.0 282940.0 282530.0 True False 478879.6351220057 381376.7680353382 404963.4758078972 374059.20496433397 323875.78429258557 291705.39522330987 399366.08616568457 355812.35106300906 339535.9060041319 274372.6247989021 1.745362298709627 1.3899956976934686 1.475961663831113 1.3633255330720253 1.180423099899147 1.0631723752947715 1.455560978280522 1.296821617403694 1.237499208432293 1.0 18.0657770199525 -1.5228787452806307 0.4701592196164068 1.214134587500008 14.120435799401314 0.5998258172946713 0.1305028567079194 72.36318022299467 0.8312809933544609 0.07930831987289215 907.6479006113628 0.02999999999997975 1.5228787452806307 12.906301211901306 S(ph)LSPILPGR ddPTM_A459_Selumetinib_30min_R2 3 SLSPILPGR 9 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 S(0.5)LS(0.5)PILPGR;S(0.674)LS(0.326)PILPGR;S(0.808)LS(0.192)PILPGR 109.83 0.011204 84118000.0 72124.4 60304.6 72010.0 75478.5 69643.5 51319.700000000004 47959.9 50789.399999999994 47520.5 51582.8 True False 68116.0145848491 64929.76891014895 67376.9549985598 65198.19809232505 60894.26090921043 58388.522841147125 50190.13038073898 50937.18874536222 57025.927833708076 50093.47053579024 1.3597783075577146 1.2961722998161733 1.345024696390741 1.301530866098466 1.2156127387042062 1.1655914876057614 1.0019295897033063 1.016842877934943 1.1383904373917317 1.0 15.61233494625261 -6.734357621704714 1.4060115845366072 1.0394362692163697 1.329420932053777 0.8918405403925639 0.04431763505798448 0.123608953316903 0.510451054307426 0.020172265825100632 0.018673743818906362 1.843496758462778e-07 6.734357621704714 0.2899846628374074 S(ph)LSPLGGR ddPTM_A459_Selumetinib_30min_R2 1 SLSPLGGR 8 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8YFE7 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 S(0.994)LS(0.006)PLGGR 109.44 0.01245 2982700.0 13040.0 10860.0 12900.0 11311.0 13125.0 11651.0 15364.0 10952.0 9514.6 8755.9 True False 12315.289003255952 11692.92707959621 12070.028044458033 9770.422287436668 11476.120161011266 13255.819492752384 16078.456443188448 10983.868506798803 11417.785860136124 8503.094416439691 1.4483302666198612 1.3751378623985837 1.4194865367038747 1.1490431375837429 1.3496404484023596 1.5589406448461727 1.89089473264024 1.2917495642013381 1.3427800869835378 1.0 13.053772242010936 -6.650411631569748 9.858146891502434 1.464604419838201 1.3419712269468442 0.0003977491266440314 0.22513373210690296 0.9856190137627747 82.10736479125477 0.07522326493587622 0.07518724692947448 2.2366002465173014e-07 6.650411631569748 -0.12263319289135688 S(ph)LSPLIK ddPTM_A459_Selumetinib_30min_R1 2 SLSPLIK 7 0 Q7Z4H7;Q5VY60;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 S(0.563)LS(0.437)PLIK;S(0.874)LS(0.126)PLIK 99.136 0.021407 107355000.0 16802.199999999997 18813.7 20736.8 22120.0 19331.5 15944.5 19107.4 17203.2 10066.099999999999 15892.6 True False 17193.658568610084 16610.983257748157 17920.85645908889 18257.157243825684 17582.969238253525 15784.112806447682 17666.11343454402 16746.915252131006 17081.43650114439 17932.570017033264 0.9587950055278567 0.9263024341725812 0.999346799821038 1.0181004299151828 0.9805047029819111 0.8801924538119819 0.9851411938034453 0.933882607803786 0.9525370030575415 1.0 14.130294643278711 S(ph)LSPLIK ddPTM_A459_Selumetinib_30min_R2 2 SLSPLIK 7 0 Q7Z4H7;Q5VY60;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 S(0.957)LS(0.043)PLIK;S(0.617)LS(0.383)PLIK 99.139 0.021405 65201000.0 309113.0 226917.0 302903.0 357150.0 313540.0 213325.0 243838.0 292793.0 188909.0 248217.0 True False 291933.7369373818 244320.80424684487 283414.55075585016 308505.55388188583 274150.3021168356 242708.5823784572 255176.95015583065 293644.9791555093 226696.07855847364 241050.3302647826 1.211090383558928 1.0135675980135344 1.1757484440885537 1.2798387521104277 1.137315604652747 1.0068792775013131 1.0586044411369635 1.2181894911031814 0.9404512257231032 1.0 17.87897488081913 -6.59138176433574 7.231258404765734 1.0600004792274336 1.1652840218016989 0.29273465095336815 0.09171031638024964 0.3523852722349067 31.012834240563247 0.03076726482706295 0.030774495853418033 2.562230730508678e-07 6.59138176433574 0.10528354257426531 S(ph)LSPNHNTLQTLK ddPTM_A459_Selumetinib_30min_R2 1 SLSPNHNTLQTLK 13 0 A0A499FJI4;O75592-2;O75592 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 S(0.802)LS(0.198)PNHNTLQTLK 169.98 0.00023965 13346000.0 25039.0 18354.0 29991.0 36919.0 43239.0 26032.0 23773.0 27003.0 31304.0 33126.0 True False 23647.432619058698 19761.6927825883 28061.411711731853 31890.56851117267 37806.93025843548 29617.671705032197 24878.491605305833 27081.57425941271 37565.674706840146 32169.566308315676 0.735087081759817 0.6142977680578802 0.8722968610390658 0.9913272751497776 1.175239041026878 0.9206736398363 0.7733548959556493 0.84183833875349 1.1677395444752887 1.0 14.973408866082227 -5.443458029893329 3.781883026831431 0.9703615550242298 0.6770429640544408 0.4963926216835153 0.12175805035530143 0.2080812697415998 5.5682944710823055 0.035271735832629304 0.07749400954071711 3.601985582085151e-06 5.443458029893329 -0.2933185909697891 S(ph)LSPPQSQSK ddPTM_A459_Selumetinib_30min_R1 1 SLSPPQSQSK 10 0 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6;I3L0Y9 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 S(0.894)LS(0.105)PPQS(0.001)QS(0.001)K 86.911 0.034395 23293000.0 2487.1 2873.3 3399.2 3243.4 2825.5 2846.5 2655.1 2429.2 1608.0 1970.2 True False 2545.0445909458376 2536.8927002390687 2937.6073104690663 2677.0010761584185 2569.9340238825425 2817.866794415212 2454.823669366725 2364.7697248463437 2728.6585563267 2223.0943613731515 1.1448207665705317 1.141153854878248 1.321404687767989 1.20417788946435 1.156016617439107 1.2675425944019236 1.1042372793615651 1.0637289023510828 1.227414635985705 1.0 11.118353470901877 -9.316957599495444 0.36930330620705326 0.9724917573961958 1.2087551357120863 0.3683912456676235 0.07222913141037726 4.054089285868441 0.8780813684714811 0.27459978721017536 0.06174101614587745 4.819948528565593e-10 9.316957599495444 0.2362633783158905 S(ph)LSPQDR ddPTM_A459_Selumetinib_30min_R2 1 SLSPQDR 7 0 E9PKP7;P17480-2;P17480 E9PKP7 UBTF Nucleolar transcription factor 1 1 S(0.962)LS(0.038)PQDR 88.177 0.03262 16234000.0 97819.0 88241.0 105090.0 124440.0 108900.0 80797.0 87331.0 95002.0 94535.0 95905.0 True False 92382.61158048273 95008.80096046512 98328.62381334047 107491.05732902657 95219.00842164774 91926.05334785988 91392.06454309353 95278.44009157222 113444.64152859489 93135.97345888491 0.991911161171953 1.020108529841125 1.0557534340557235 1.1541303895479091 1.0223655252144048 0.9870091000706709 0.9812756677036157 1.023003642450069 1.2180539625612576 1.0 16.50705089112074 -5.033711919822634 3.2701427081949355 1.0530603758930415 0.9945031550597155 0.07519148155787725 0.0718711213060655 0.7601077133374501 15.89468821975564 0.019372813655489016 0.08187310721802644 9.253117566471875e-06 5.033711919822634 -0.05855722083332593 S(ph)LSPQEDALTGSR ddPTM_A459_Selumetinib_30min_R1 1 SLSPQEDALTGSR 13 0 Q96EN8 Q96EN8 MOCOS Molybdenum cofactor sulfurase 1 S(0.5)LS(0.5)PQEDALTGSR 130.27 0.0016418 3322900.0 934.11 1296.1 1078.8 1038.6 1068.9 983.09 1101.6 840.57 676.42 758.17 True False 955.8729455383439 1144.3520094594564 932.3048854242255 857.2280069365893 972.2181837296226 973.2010071743022 1018.5054250967518 818.2753530438379 1147.8353362378778 855.4885047011888 1.1173416595144292 1.3376591306263828 1.089792417198952 1.0020333437864346 1.1364479807583223 1.1375968254701783 1.190554191552232 0.9565006993631678 1.341730870643086 1.0 9.740604658958134 S(ph)LSPSSNSAFSR ddPTM_A459_Selumetinib_30min_R2 4 SLSPSSNSAFSR 12 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 S(0.97)LS(0.029)PSSNSAFSR;S(0.977)LS(0.023)PSSNSAFSR;S(0.984)LS(0.015)PSSNSAFSR;S(0.941)LS(0.059)PSSNSAFSR 161.87 0.00048615 119304000.0 147872.0 145505.0 169505.0 179439.0 173803.0 120176.0 124398.0 136524.0 112654.0 144626.0 True False 139653.86621851716 156664.76562768398 158599.23284308953 154999.0986504599 151968.31332146598 136729.1531508894 130182.75348996067 136921.26223723512 135187.94781575422 140450.2715965242 0.9943296273552614 1.1154465124691226 1.1292198373151061 1.1035870339626723 1.082007970465376 0.973505793877533 0.9268957048651402 0.9748736024560567 0.9625324770044787 1.0 17.09969988872369 -6.765142957599802 4.743786267116561 0.9621967670779921 1.0911236862358047 0.7041385500146298 0.0379621420331636 0.10107415012732368 5.854118712444027 0.013392539411574938 0.012490683628760864 1.7173429928133968e-07 6.765142957599802 0.12892691915781263 S(ph)LSPVAAPPLREPR ddPTM_A459_Selumetinib_30min_R2 1 SLSPVAAPPLREPR 14 1 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 S(0.685)LS(0.315)PVAAPPLREPR 67.685 0.036053 33393000.0 87833.0 110190.0 87556.0 110490.0 116900.0 71717.0 84926.0 76786.0 70189.0 107170.0 True False 82951.59348335728 118641.21868330642 81922.74228376482 95441.07139411883 102213.97690074041 81595.36576789305 88875.22727767659 77009.43454739336 84228.76124451838 104075.72363889983 0.7970311479280737 1.1399509370210377 0.7871455457566955 0.917034905519949 0.9821116138032446 0.7839999849628293 0.8539477235444191 0.7399365755513225 0.8093026721270534 1.0 16.66727406401389 -6.766487712451614 24.999744711727608 0.8222153187231341 0.9285529927149413 0.12368103013012344 0.11224778128082684 220.3277463743818 1091073.0028192778 0.03695381323564041 0.03359534814662171 1.712033614799964e-07 6.766487712451614 0.10633767399180716 S(ph)LSQGSTNATVLDVAQTGGHK ddPTM_A459_Selumetinib_30min_R2 1 SLSQGSTNATVLDVAQTGGHK 21 0 A0A2R8Y661;H0Y8T6 A0A2R8Y661 RAPGEF2 1 S(0.433)LS(0.364)QGS(0.151)T(0.046)NAT(0.005)VLDVAQTGGHK 69.72 0.004455 6811300.0 38281.0 35277.0 36857.0 42318.0 41951.0 30349.0 38515.0 40880.0 31208.0 37646.0 True False 36153.49527098475 37982.632466566814 34485.660746867434 36554.21539737821 36680.74033330161 34529.29926920798 40306.02381602467 40998.95403195166 37450.47202437605 36559.06216394531 0.9889065290804825 1.0389389174218324 0.9432862525909466 0.9998674263977188 1.003328262875307 0.944479897059857 1.1024906392641174 1.1214443589415974 1.024382733244997 1.0 15.15794144149961 -7.267074325624741 24.999800546417973 1.072199797323342 0.9882655776927625 0.42872036881229236 0.04208545944970644 413.7487039101117 1835616.2628318989 0.016833129964315026 0.011704012879517776 5.406617855878371e-08 7.267074325624741 -0.08393421963057945 S(ph)LSQGSTNSNMLDVQGGAHK ddPTM_A459_Selumetinib_30min_R2 1 SLSQGSTNSNMLDVQGGAHK 20 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;B7Z7Y1;Q8TEU7-2 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 S(0.529)LS(0.406)QGS(0.032)T(0.032)NS(0.001)NMLDVQGGAHK 126.93 0.0001374 4711700.0 12605.0 11708.0 13991.0 15665.0 16387.0 12120.0 13308.0 12112.0 11588.0 21248.0 True False 11904.464561812967 12605.965952846458 13090.834292249016 13531.39997636772 14328.31855836125 13789.41998559428 13926.848369301722 12147.243914750467 13905.923795772542 20634.515031065996 0.5769200072737534 0.6109165121577962 0.634414439716189 0.6557653502394273 0.6943860098863219 0.6682696426271137 0.6749297644424576 0.5886856994924455 0.6739157074850889 1.0 14.332771910916058 -14.522878745279465 0.38535066359901 6.21249458432544 0.6352816359786804 0.8985194938089279 0.0362041009727889 198.0969546067681 1.4576700601460042 864.4953421950984 0.02596105354622044 3.000000000006026e-15 14.522878745279465 -5.57721294834676 S(ph)LSRTPETLLPFAEAEAFLKK ddPTM_A459_Selumetinib_30min_R1 1 SLSRTPETLLPFAEAEAFLKK 21 2 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 S(0.412)LS(0.412)RT(0.173)PET(0.003)LLPFAEAEAFLKK 100.92 0.00010082 5931900.0 1167.8 1155.7 2257.9 2476.6 1807.4 1460.2 1123.4 956.69 848.5 594.85 True False 1195.0074678567603 1020.3901067296465 1951.2895817569158 2044.108301539723 1643.9209891223877 1445.5117137555217 1038.6610335454707 931.3154734329196 1439.8425280119432 671.2047918296711 1.7803917409457537 1.52023662397897 2.9071448915580547 3.0454316274584166 2.4492092564493473 2.1536075596467783 1.5474577151246671 1.3875280462378698 2.14516127646676 1.0 9.390609205201189 -7.165886122236967 3.4118610585916342 1.5472771892779709 2.3613380460173157 0.37671099144429543 0.5005746181889508 0.3103696001125721 6.829091532842007 0.2256988499827425 0.16776533762622237 6.825176358405699e-08 7.165886122236967 0.8140608567393448 S(ph)LSS(ph)SPVKK ddPTM_A459_Selumetinib_30min_R2 2 SLSSSPVKK 9 1 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 2 S(0.999)LS(0.014)S(0.733)S(0.254)PVKK;S(0.913)LS(0.087)S(0.524)S(0.476)PVKK 141.1 0.0075179 38549400.0 127285.0 129257.0 119260.0 129082.0 124551.0 104831.0 118739.0 112528.0 92318.0 120681.0 True False 120211.00926222654 139170.59627323822 111586.94144046998 111500.8089211297 108903.78987993237 119270.51868893014 124260.59877686494 112855.43784998683 110784.1795804392 117196.62596310602 1.0257207344865837 1.1874966120359958 0.952134419600083 0.9513994793351015 0.9292399758523401 1.017695839865535 1.0602745408044654 0.9629580794033625 0.9452847184808418 1.0 16.838571510268956 -5.277409992451912 24.925124926283694 0.9778046060374286 1.106608680125344 0.497743182233336 0.05192652113702751 552.4480460259355 862198.0521351203 0.013761541982907926 0.028797948586155735 5.279466123997631e-06 5.277409992451912 0.1288040740879155 S(ph)LSSLR ddPTM_A459_Selumetinib_30min_R1 1 SLSSLR 6 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915;C9J1G1;Q70YC5-2;Q70YC5;Q70YC5-4;Q70YC5-3;Q8TF61 H0Y9X0 FRYL;ZNF365;FBXO41 Protein furry homolog-like;Protein ZNF365;F-box only protein 41 1 S(1)LSSLR 98.629 0.034365 19438000.0 2416.2 2380.4 2273.5 2171.1 2467.2 2064.4 2475.7 2160.9 1408.5 1926.5 True False 2472.492758893221 2101.7016613820633 1964.7711874415825 1791.958141594481 2244.042195619538 2043.634010325229 2288.9559558024953 2103.5859124075696 2390.121627230197 2173.7850406991047 1.1374136414601739 0.9668396929928919 0.9038479659468528 0.8243492838731536 1.0323201943177591 0.9401270006292719 1.0529817405801776 0.9677064995033002 1.0995206897097412 1.0 11.08599356815042 -7.258944825963186 24.9274561308114 1.0273611070326483 0.9610022943200016 0.11700184982826789 0.08293880175587683 495.71545981012196 4953592.130365344 0.03362420489669189 0.024862182449124907 5.508776770657664e-08 7.258944825963186 -0.06635881271264665 S(ph)LSSPTVTLSAPLEGAK ddPTM_A459_Selumetinib_30min_R2 1 SLSSPTVTLSAPLEGAK 17 0 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5;Q96PU5-2;Q96PU5-9;Q96PU5-6;Q96PU5-5 A0A1B0GVY1;Q96PU5-9 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 S(0.731)LS(0.232)S(0.037)PTVTLSAPLEGAK 244.18 4.8141e-23 12741000.0 53922.0 41852.0 54449.0 53834.0 42585.0 46104.0 55886.0 56914.0 43077.0 38446.0 True False 50925.23110686866 45061.91382460963 50945.81061958881 46501.71633117014 37235.09158526969 52454.40750955763 58484.80973600816 57079.6103173801 51693.60367194456 37335.964085295716 1.363972575892982 1.2069305006203572 1.3645237739998028 1.2454939217569108 0.9972982484181854 1.4049297719947218 1.566447021493725 1.5288104034752958 1.3845525336870412 1.0 15.18827836418852 -6.962517849897337 24.999423091713176 1.424258789175774 1.237691562001068 0.1140542820139896 0.1742268664114361 258.5339433876672 172433.3998931107 0.05955434468953893 0.05252189563306949 1.0901396857339312e-07 6.962517849897337 -0.18656722717470609 S(ph)LSSS(ph)PVKK ddPTM_A459_Selumetinib_30min_R2 1 SLSSSPVKK 9 1 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 2 S(1)LS(0.001)S(0.224)S(0.775)PVKK 144.7 0.0064681 25708000.0 147220.0 131680.0 142780.0 148040.0 146160.0 108760.0 120640.0 124130.0 96761.0 140190.0 True False 139038.10176835436 141779.4325820651 133593.69024710963 127876.6966167558 127798.0741130215 123740.70277501925 126249.99904362482 124491.19774917215 116115.90372823163 136142.35044263676 1.0212700259419842 1.0414057941639807 0.9812794462028845 0.939286681925154 0.9387091797483613 0.9089067609946774 0.9273381767917981 0.9144193364108709 0.8529006833707985 1.0 17.054756397042453 -5.622724154801449 1.4781942801635704 0.9180135447594215 1.0368911412826263 0.6024282616955017 0.034527916898528334 0.27283764485127826 1.1611772373246212 0.0105974238575197 0.029614713958393775 2.383833096991062e-06 5.622724154801449 0.11887759652320473 S(ph)LSVPVDLSR ddPTM_A459_Selumetinib_30min_R2 1 SLSVPVDLSR 10 0 Q9NYF3;D6RHW3 Q9NYF3 FAM53C Protein FAM53C 1 S(0.77)LS(0.23)VPVDLSR 149.94 0.00072897 5667000.0 22592.0 20651.0 20317.0 24340.0 25202.0 16259.0 21718.0 22947.0 14144.0 20475.0 True False 21336.427082941595 22234.8652965692 19009.826339477037 21024.85001115803 22035.899451261397 18498.52966549319 22727.930033400582 23013.77197091966 16973.1952163796 19883.833549561194 1.0730539978500502 1.1182383538439895 0.9560443307923665 1.0573841286064285 1.1082319411061303 0.9303301407842165 1.1430356212120953 1.157411216180068 0.8536178485940994 1.0 14.279308310984867 -8.26635811589875 24.995445526352132 0.926808929164616 1.0648151235623415 0.3457137188434445 0.0775795201453912 497.7029022611657 2529122.7275770498 0.06606027855788478 0.01925469815153134 5.41554144841326e-09 8.26635811589875 0.13800619439772555 S(ph)LSYSPVER ddPTM_A459_Selumetinib_30min_R1 1 SLSYSPVER 9 0 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.952)LS(0.019)YS(0.029)PVER 114.51 0.0084921 33878000.0 3843.1 3975.7 4226.7 4371.7 4611.2 3521.8 4355.2 3282.4 1871.8 3182.6 True False 3932.636752629142 3510.223195747212 3652.737355601202 3608.2646619725474 4194.117774173482 3486.3738895385545 4026.683757608364 3195.340089262163 3176.3078891370155 3591.117711149217 1.0951010434494037 0.9774737221364661 1.017158904109625 1.0047748228274709 1.1679143129037937 0.9708325290241898 1.1212898271495975 0.8897898499238003 0.8844900514610379 1.0 11.810217227697509 -7.775268211658063 24.99998572224458 0.9153549178802296 1.0462226872240157 0.4244837538824424 0.06676584038246959 217.92963265716457 393970.8139613236 0.034723702029778716 0.01681441911975566 1.677767542145445e-08 7.775268211658063 0.13086776934378608 S(ph)LTAHSLLPLAEK ddPTM_A459_Selumetinib_30min_R2 1 SLTAHSLLPLAEK 13 0 F2Z2E2;Q86VI3 F2Z2E2 IQGAP3 Ras GTPase-activating-like protein IQGAP3 1 S(0.99)LT(0.01)AHSLLPLAEK 134.88 0.00077861 4287200.0 89650.0 63887.0 61085.0 86815.0 75044.0 84499.0 81204.0 68901.0 60427.0 83850.0 True False 84667.61189738459 68786.92747091745 57154.85760431932 74990.64723577167 65616.3018181279 96137.97024444974 84980.14690267341 69101.49050282534 72514.08847144854 81429.03263153623 1.039771800808476 0.8447469563119594 0.7018977845769484 0.9209325570046 0.8058096688319947 1.1806350528498966 1.0436099282574787 0.8486099892099588 0.8905188497028139 1.0 16.313255642908203 S(ph)LTELVQQPCPPIEASK ddPTM_A459_Selumetinib_30min_R2 2 SLTELVQQPCPPIEASK 17 0 A0A2R8YDI1;A0A2R8Y852;P39880-6;P39880-4;P39880-5;P39880-2;P39880;P39880-3 A0A2R8YDI1 CUX1 Homeobox protein cut-like 1 1 S(0.966)LT(0.034)ELVQQPCPPIEASK;S(0.985)LT(0.015)ELVQQPCPPIEASK 192.85 8.412399999999999e-08 3908700.0 28709.0 20820.8 26166.0 25911.0 28813.0 21965.5 29997.0 28567.0 28450.0 21169.2 True False 27113.468711232752 22417.688410576142 24482.508047386727 22381.877101031874 25193.25334851182 24991.048242043813 31391.91993792785 28650.12524047856 34140.7949594174 20557.990191812973 1.3188774028129675 1.090461090865963 1.1908998797526744 1.0887191253717616 1.2254725833337927 1.2156367431285313 1.5269936236485504 1.3936248131827693 1.660706841518664 1.0 14.327411608962873 -7.1416198744005595 5.378684414990898 1.4271493057302 1.1774750629381845 0.25700449496112376 0.1692515370921839 0.2607371303295163 10.43956508974688 0.0611569344084615 0.04713382634768816 7.217389203367218e-08 7.1416198744005595 -0.24967424279201555 S(ph)LTFTGGAK ddPTM_A459_Selumetinib_30min_R2 1 SLTFTGGAK 9 0 F5H8C5;F5H0S5;F5H7J1;Q8NHQ8-2;Q8NHQ8 F5H8C5 RASSF8 Ras association domain-containing protein 8 1 S(0.979)LT(0.007)FT(0.014)GGAK 83.869 0.037713 4110500.0 19190.0 18164.0 17116.0 25337.0 22186.0 19091.0 19916.0 20600.0 23345.0 15755.0 True False 18123.496623656563 19557.1203935346 16014.775194491755 21886.05689123709 19398.7963346435 21720.611959156795 20842.133462805326 20659.942589486425 28014.65231379963 15300.11221359396 1.1845335753520854 1.278233788125968 1.04670965617251 1.4304507434783125 1.2678858863144749 1.4196374285319489 1.362220954450736 1.3503131415683554 1.8310095980151673 1.0 13.901254613474034 -6.103429063588868 1.2720626037106515 1.4097167480051391 1.1856636143069403 0.13667117912333726 0.20478839920324754 0.8328675673388085 2.739534957663632 0.07488075957871826 0.12586069104184686 7.880811438458755e-07 6.103429063588868 -0.2240531336981988 S(ph)LTLDAAPDHNPPCR ddPTM_A459_Selumetinib_30min_R2 2 SLTLDAAPDHNPPCR 15 0 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 S(0.574)LT(0.426)LDAAPDHNPPCR;S(0.961)LT(0.039)LDAAPDHNPPCR 141.85 0.00025387 17459000.0 73736.0 91520.0 79702.0 81178.0 83022.0 62028.0 84160.0 69663.0 68380.0 76446.0 True False 69638.04830859507 98539.28971681812 74574.06009297619 70121.4163601393 72592.03413390306 70571.79396587804 88073.60675987622 69865.70779666949 82057.91069683537 74238.80534943847 0.9380275986502227 1.3273286019757249 1.0045158962615264 0.9445385877383288 0.9778179187045893 0.9506051940585523 1.186355388469925 0.9410941820496032 1.105323695749046 1.0 16.179885874358845 S(ph)LTLLPHGTPNSASPCSQR ddPTM_A459_Selumetinib_30min_R2 2 SLTLLPHGTPNSASPCSQR 19 0 Q9BXB5 Q9BXB5 OSBPL10 Oxysterol-binding protein-related protein 10 1 S(0.586)LT(0.414)LLPHGTPNSASPCSQR;S(0.931)LT(0.069)LLPHGTPNSASPCSQR 98.727 0.00094425 5925000.0 12356.9 9307.400000000001 12250.4 18431.4 21955.0 14208.9 11358.599999999999 14038.9 13227.8 17586.300000000003 True False 11670.152966589985 10021.247651992067 11462.22260122702 15921.011524061547 19196.816619809688 16166.046999448055 11886.797406638914 14079.75087473499 15873.729615612694 17078.537824305153 0.6833227227439648 0.586774333674539 0.6711477714980185 0.9322233371409416 1.1240316247969382 0.9465709047083355 0.696007909396221 0.8244119619360816 0.9294548385179762 1.0 14.059896843739564 -5.723179149130574 5.582786269705538 0.9148455693741068 0.6363432312536215 0.5819728720129802 0.10668935191079011 0.14818245846355024 11.46496291435095 0.03294338781464185 0.05641701782540216 1.891563176305593e-06 5.723179149130574 -0.2785023381204853 S(ph)LTNDWEDHLAVK ddPTM_A459_Selumetinib_30min_R1 1 SLTNDWEDHLAVK 13 0 P07900;P07900-2;P08238 P07900;P08238 HSP90AA1;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta 1 S(0.507)LT(0.493)NDWEDHLAVK 75.682 0.030858 9470100.0 1408.1 1878.4 1700.7 1644.1 1469.4 1432.0 1821.9 1704.5 778.59 1537.4 True False 1440.9059903143543 1658.476054755532 1469.7542812764011 1356.9887985792861 1336.4930294436401 1417.59538015197 1684.472616179894 1659.2911230037037 1321.2103640363218 1734.7402655441497 0.8306177120194843 0.9560371011710532 0.8472474585786891 0.7822432127345754 0.7704283205903518 0.817180190204037 0.9710229534860725 0.9565069514791142 0.7616185490580559 1.0 10.760503955729398 -7.245829355315182 24.489029090741486 0.9186626955711081 0.8348735453345321 0.24494871449446964 0.07585541276542902 1011.5263011224592 1586885.9655822334 0.03026230315431535 0.023350586059682134 5.677676510696788e-08 7.245829355315182 -0.08378915023657607 S(ph)LTNLSFLTDSEK ddPTM_A459_Selumetinib_30min_R1 2 SLTNLSFLTDSEK 13 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 S(0.834)LT(0.166)NLSFLTDSEK;S(0.808)LT(0.192)NLSFLTDSEK 144.4 0.00067113 41647000.0 3476.1 4847.3 4104.3 4550.1 4063.7999999999997 3716.9 4277.1 4270.700000000001 2051.91 3890.9 True False 3557.086366686835 4279.775862551364 3546.958603306127 3755.5104509553003 3696.2300075221638 3679.5113606751797 3954.4749034870324 4157.42716281133 3481.9414044230844 4390.3349155754695 0.8102084317229327 0.9748176266389432 0.8079016001086113 0.8554040917543625 0.841901604000449 0.8380935467181511 0.9007228331164102 0.9469498894178076 0.7930924340351114 1.0 12.1001152842427 -11.033596687418786 4.045832564737068 1.001395634934415 0.866854922478605 0.3367514404244174 0.057379800268643394 0.0006998305157613238 8.463384736544412e-05 0.05382662054421739 0.012921625499933077 9.255573044249646e-12 11.033596687418786 -0.13454071245581012 S(ph)LTNLSFLTDSEK ddPTM_A459_Selumetinib_30min_R2 2 SLTNLSFLTDSEK 13 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 S(0.982)LT(0.016)NLS(0.003)FLTDSEK;S(0.999)LT(0.001)NLSFLTDSEK 196.18 0.00019383 17542300.0 61810.0 54633.0 54200.0 59970.0 50802.0 51468.0 52061.0 46289.0 44215.0 51290.0 True False 58374.84764503452 58823.175427217306 50712.83100849807 51801.98254597971 44419.79858435763 58557.24982001372 54481.93965691446 46423.693326443536 53059.23547032126 49809.124432576 1.1719709653610453 1.1809718821065236 1.0181433941314382 1.0400099005173506 0.8918004299490626 1.1756329886761934 1.0938144421844598 0.9320319089183119 1.0652513184034136 1.0 15.604122430433813 -5.260170193469264 24.585969569608746 1.027976526281415 1.1764714425760798 0.3878693861759076 0.07506028204524369 88.32214749298545 1710864.1645121383 0.019638210172684446 0.04638009339729978 5.4932555925439004e-06 5.260170193469264 0.14849491629466494 S(ph)LTNLSFLTDSEKK ddPTM_A459_Selumetinib_30min_R1 1 SLTNLSFLTDSEKK 14 1 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 S(0.998)LT(0.002)NLSFLTDSEKK 82.87700000000002 0.014858 7879100.0 1644.8 1944.0 2946.0 3148.8 1987.2 2189.2 2321.5 2041.0 1272.8 2092.6 True False 1683.12063977633 1716.395576258918 2545.9493812196592 2598.921190296489 1807.458110868655 2167.1786356345624 2146.3873859496266 1986.866049897657 2159.84863836606 2361.2055936501147 0.7128225700899031 0.726914920443499 1.0782412967622843 1.1006755181698926 0.765481038893594 0.9178271648443742 0.909021811451663 0.8414625372906314 0.9147228196369029 1.0 11.205307949280737 -5.173364935572427 9.238214662077578 0.9326575975198982 0.7180431361321237 0.45936793871381953 0.0956042654402154 0.39307086556801873 38.62670952101101 0.025862226592135863 0.06879672273317049 6.708648914579161e-06 5.173364935572427 -0.2146144613877745 S(ph)LTNSHLEK ddPTM_A459_Selumetinib_30min_R1 2 SLTNSHLEK 9 0 F8VX12;F8VX04;Q9H2H9 F8VX12 SLC38A1 Sodium-coupled neutral amino acid transporter 1 1 S(0.955)LT(0.045)NSHLEK;S(0.999)LT(0.001)NSHLEK 107.99 0.0081142 30644000.0 15601.1 9644.0 17098.4 9225.5 15064.400000000001 11437.7 13923.2 17366.6 5371.6 10472.5 True False 15964.575275543852 8514.875996626039 14776.531194788273 7614.439609082909 13701.827679835831 11322.647122600687 12872.96181436737 16905.981353333005 9115.212873858522 11816.747385788407 1.3510126563883302 0.7205769674713183 1.2504736466279625 0.6443769474365282 1.1595261566067279 0.9581864410690578 1.0893828389569566 1.4306797633387038 0.771380869563233 1.0 13.528545361244754 -7.371428708719479 6.630713006300454 1.110650099962869 1.0015568668576724 0.002998747274175928 0.2544357547731664 0.9714454934381901 51.321391832217415 0.10023954494074196 0.06709567578218491 4.2517849592914175e-08 7.371428708719479 -0.10909323310519659 S(ph)LTNSHLEK ddPTM_A459_Selumetinib_30min_R2 2 SLTNSHLEK 9 0 F8VX12;F8VX04;Q9H2H9 F8VX12 SLC38A1 Sodium-coupled neutral amino acid transporter 1 1 S(0.968)LT(0.029)NS(0.003)HLEK;S(0.636)LT(0.328)NS(0.036)HLEK 89.23100000000002 0.01994 10046500.0 117628.0 45713.0 93127.0 109606.0 72162.0 57155.0 157854.0 113988.0 94469.0 79322.0 True False 111090.70666219237 49219.04010953789 87135.31020901089 94677.47371910376 63096.364423534826 65027.582448567715 165194.52378176703 114319.68620827075 113365.43968440083 77031.76775669311 1.442141468349465 0.6389447048002006 1.1311607242901407 1.2290705052770576 0.8190953714424206 0.8441657817584957 2.144498673632135 1.4840589738165237 1.4716712725906615 1.0 16.23316591280367 -7.227921208208205 24.97288783227551 1.5653958319268098 1.0060002800502625 0.35263879423238675 0.334952409288186 618.9206562438078 461130.6159700184 0.12288719535862062 0.0951824999889454 5.916689678659431e-08 7.227921208208205 -0.5593955518765472 S(ph)LTQPITTEEVVIAATLQASAHQK ddPTM_A459_Selumetinib_30min_R1 1 SLTQPITTEEVVIAATLQASAHQK 24 0 O95425-4 O95425-4 SVIL Supervillin 1 S(0.488)LT(0.488)QPIT(0.023)TEEVVIAATLQASAHQK 232.18 4.6775e-39 21285000.0 3894.4 3063.8 3616.6 3563.2 4402.8 3835.8 4227.6 3306.6 1492.2 2099.2 True False 3985.131942816719 2705.088871678022 3125.485584561786 2940.954009547906 4004.5675173774766 3797.2153346277423 3908.7087283397136 3218.898226649481 2532.1544140240694 2368.6527679395595 1.6824466619830059 1.1420369031257886 1.3195203732966647 1.2416146635566931 1.6906519906929898 1.6031118558296997 1.6501822391383334 1.3589574082863702 1.0690272750390242 1.0 11.209851007221591 -8.229530378039723 3.2900306279914733 1.0114211991072914 1.4629960110166598 0.47791520514092245 0.18158372118646507 0.23364135553040016 4.882380879493039 0.1698776584703627 0.05091724757159893 5.894807426117633e-09 8.229530378039723 0.4515748119093683 S(ph)LTQPITTEEVVIAATLQASAHQK ddPTM_A459_Selumetinib_30min_R2 1 SLTQPITTEEVVIAATLQASAHQK 24 0 O95425-4 O95425-4 SVIL Supervillin 1 S(0.768)LT(0.231)QPITTEEVVIAATLQASAHQK 117.01 9.9682e-08 14558000.0 43665.0 26768.0 54077.0 64334.0 61129.0 48774.0 43096.0 37031.0 33592.0 42685.0 True False 41238.2741048444 28821.019527314143 50597.7446945858 55571.59821765983 53449.42851980625 55492.175773710864 45100.04939310395 37138.75407918795 40311.33863890155 41452.57314105102 0.9948302597409955 0.6952769718117285 1.2206177050195757 1.3406067224962341 1.2894115966681592 1.3386907390498335 1.0879915521683452 0.8959336240193244 0.9724689104759268 1.0 15.33917403839022 -7.602965701116722 5.678364151540614 0.9535851344328391 1.1500251601728644 0.1780197760832124 0.18257038517320603 0.4079308698777119 21.88265508064319 0.10062894224410447 0.05715706592597241 2.494791748078816e-08 7.602965701116722 0.19644002574002528 S(ph)LVGGLLQSK ddPTM_A459_Selumetinib_30min_R2 1 SLVGGLLQSK 10 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 S(1)LVGGLLQSK 104.59 0.013027 3660300.0 19295.0 15908.0 24067.0 25866.0 29039.0 22930.0 24179.0 34406.0 16576.0 22487.0 True False 18222.661144004865 17128.092447717907 22518.555422168327 22343.006178661188 25390.861208046164 26088.399362184573 25303.371409779575 34506.11576378009 19891.66317213719 21837.74188175737 0.8344572091140778 0.7843344124342009 1.031176004556574 1.023137204370288 1.1627054365569258 1.194647299315232 1.1586990791807688 1.5801137292773628 0.9108846180087017 1.0 14.414536062527969 -5.64521108157471 1.0205571456904023 1.2058557543142852 0.7725376096225315 0.3831655930774637 0.16902853406295634 0.6313193725480534 1.1764537699356346 0.061527063485702846 0.2206725004526429 2.2635438825188697e-06 5.64521108157471 -0.43331814469175367 S(ph)LVGTPYWMAPELISR ddPTM_A459_Selumetinib_30min_R1 3 SLVGTPYWMAPELISR 16 0 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 S(0.679)LVGT(0.32)PYWMAPELISR;S(1)LVGTPYWMAPELISR;S(1)LVGTPYWMAPELISR 215.37 4.7039e-09 879980000.0 5848.5 6638.4 5825.9 5811.499999999999 6401.1 5099.5 5704.6 6027.5 2899.05 5149.9 True False 5984.758670800015 5861.173041891564 5034.774779378012 4796.630620365868 5822.1216352059955 5048.2036599755365 5274.297429200194 5867.63111992069 4919.476111765496 5810.9398292739725 1.0299123457879205 1.0086445934897708 0.8664303756879658 0.8254483373243199 1.0019242680634366 0.8687413410381616 0.9076496374355286 1.0097559589863798 0.8465887199489627 1.0 12.504555800680892 -5.148967757083793 5.978004155573388 0.9142313326774485 1.0238768886841598 0.29519478526233367 0.06413433486129914 0.26828095872431823 12.244414858162184 0.015914036352474122 0.04376579529653047 7.09630450432948e-06 5.148967757083793 0.10964555600671133 S(ph)LVGTPYWMAPELISR ddPTM_A459_Selumetinib_30min_R2 7 SLVGTPYWMAPELISR 16 0 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 S(0.762)LVGT(0.23)PY(0.008)WMAPELISR;S(0.991)LVGT(0.009)PYWMAPELISR;S(0.999)LVGT(0.001)PYWMAPELISR;S(1)LVGTPYWMAPELISR;S(1)LVGTPYWMAPELISR;S(1)LVGTPYWMAPELISR;S(1)LVGTPYWMAPELISR 219.53 2.3768e-39 422561300.0 203483.91999999998 163585.5 235920.01 321449.85 287949.26999999996 161663.9 174914.03000000003 177485.4 184329.80000000002 250771.8 True False 192175.09833707145 176131.98183971312 220741.17340688518 277667.8258980785 251774.50840346504 183931.63478623066 183047.87898057495 178001.8531297104 221200.91060493517 243531.3665506157 0.7891184657608763 0.7232414630380097 0.9064178324684357 1.1401727417333236 1.0338483784228922 0.7552687663664968 0.7516398465350466 0.7309196168482649 0.9083056270657466 1.0 17.893748076118854 -6.783314023187399 24.926273816708505 0.8075600690181224 0.9193461019375843 0.09073533099552278 0.1328068682835265 523.5317497157722 596562.9665851397 0.05151690102452779 0.04547118853092505 1.6469710935492222e-07 6.783314023187399 0.11178603291946188 S(ph)LVPAAELLESR ddPTM_A459_Selumetinib_30min_R1 1 SLVPAAELLESR 12 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(1)LVPAAELLESR 117.03 0.0048666 4010700.0 630.72 1175.9 860.73 904.03 860.75 721.19 958.8 681.03 306.47 638.71 True False 645.4145488325188 1038.2250813389217 743.847593651459 746.1581312448345 782.8953144777557 713.9354833881276 886.4769440656917 662.9668721027936 520.0572063168187 720.6946500622505 0.8955450810919308 1.4405894108541588 1.032125871320411 1.0353318582015067 1.0863065438464579 0.9906213169841915 1.230031253859206 0.9198998106140087 0.7216054764273585 1.0 9.493244325592004 -7.934215598813018 6.620057220285406 0.8476180414189555 1.1037294193380014 0.30762856318367804 0.15326850471663994 0.21776390648598418 17.06008243881207 0.08164896965073805 0.038579650066472834 1.1635482603798267e-08 7.934215598813018 0.2561113779190459 S(ph)LYASS(ph)PGGVYATR ddPTM_A459_Selumetinib_30min_R2 1 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 2 S(0.991)LY(0.009)AS(0.239)S(0.754)PGGVYAT(0.007)R 127.2 0.022487 4035400.0 18187.0 17820.0 20367.0 22564.0 17316.0 16951.0 19768.0 16562.0 16408.0 17235.0 True False 17176.23934832943 19186.736699668923 19056.60939391292 19490.744274928915 15140.609272995882 19285.846384142624 20687.251169548887 16610.192678013304 19690.05847782498 16737.380768092153 1.0262202662601732 1.1463404558642878 1.1385658041694375 1.1645038459115256 0.9045984842419115 1.1522619131010523 1.2359909508055584 0.9924009561686427 1.1764121728867971 1.0 14.030786157823764 -10.651039064017672 4.559817441650574 0.9999889618488849 1.1043102046627837 0.09793545192760456 0.09481963471966862 1.0417899213992374e-05 1.991896228944704e-06 0.08989145311893143 0.021799573138472018 2.2333713260094975e-11 10.651039064017672 0.10432124281389887 S(ph)LYASSPGGVYATR ddPTM_A459_Selumetinib_30min_R1 1 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(0.901)LYAS(0.076)S(0.022)PGGVYATR 214.89 8.3241e-07 309860000.0 211.86 198.53 226.99 191.41 117.86 155.47 163.57 293.22 125.15 176.45 True False 216.79592579220167 175.28601530590694 196.1660047668197 157.98383671069956 107.19958380987308 153.90611295546566 151.23178320903747 285.44285308720765 212.37040940565083 199.09907626854755 1.0888846390215512 0.8803959244365291 0.9852682817183356 0.7934935694910448 0.5384233107404316 0.7730126921727903 0.7595805367025108 1.4336724129357508 1.0666569297348358 1.0 7.6373427173832305 -7.742384863762233 24.99698081431479 1.1876235828150528 0.8241449694359025 0.4397929509853341 0.17290090207974354 205.51046024262735 269602.9191274161 0.08480579725984383 0.04886303629287898 1.8097356274561863e-08 7.742384863762233 -0.3634786133791502 S(ph)LYASSPGGVYATR ddPTM_A459_Selumetinib_30min_R2 2 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(0.996)LYAS(0.004)SPGGVYATR;S(0.991)LYAS(0.009)SPGGVYATR 188.63 9.3604e-05 251428000.0 81856.0 79191.0 87180.0 92743.0 94551.0 62517.0 73914.0 78012.0 38026.0 93807.0 True False 77306.77121553049 85264.69506080142 81570.93371440723 80111.24340940117 82672.65808333528 71128.149277178 77351.14745781237 78239.00200441816 45632.26253521287 91098.5481701434 0.8486059631943397 0.9359610748302356 0.8954142009163353 0.8793910003898041 0.9075079652084991 0.7807824680623122 0.8490930866795461 0.8588391755518687 0.5009109744535793 1.0 16.47514044165115 -7.035239101997998 1.153031906760429 0.7739136018486409 0.8975736705479905 0.11678279278498782 0.11986316645591188 0.9339307170466012 2.5308987838260983 0.0690543857376514 0.04805636698331289 9.22063642761877e-08 7.035239101997998 0.12366006869934965 S(ph)LYESFVSSSDR ddPTM_A459_Selumetinib_30min_R1 2 SLYESFVSSSDR 12 0 P18615;P18615-3;A0A0A0MT02;A2ABK4 P18615 NELFE Negative elongation factor E 1 S(0.993)LYES(0.007)FVSSSDR;S(1)LYESFVSSSDR 190.35 0.00013569 20683500.0 695.26 984.8 661.3399999999999 883.0799999999999 1168.05 724.0699999999999 968.55 739.5999999999999 369.4 591.0799999999999 True False 711.4582052595401 869.4991581789003 571.5336604805873 728.8666554646287 1062.4000837359763 716.7865132029583 895.4914937159211 719.9834054406213 626.8448200914695 666.9508756067614 1.0667325455001284 1.303692955478722 0.8569351677672393 1.0928340933678797 1.592921042002461 1.0747216015735173 1.3426648445453255 1.0795148964841126 0.9398665524221627 1.0 9.381436693120904 -7.997481194186482 24.46064383180515 0.9831857087043873 1.1905282785126317 0.18327506970803564 0.18697488385425548 98.33057484267881 954914.2609125809 0.1048244679386563 0.04985280284980625 1.0058166159156569e-08 7.997481194186482 0.2073425698082444 S(ph)LYESFVSSSDR ddPTM_A459_Selumetinib_30min_R2 4 SLYESFVSSSDR 12 0 P18615;P18615-3;A0A0A0MT02;A2ABK4 P18615 NELFE Negative elongation factor E 1 S(1)LYESFVSSSDR;S(1)LYESFVSSSDR;S(1)LYESFVSSSDR;S(1)LYESFVSSSDR 206.74 1.0006e-05 13487600.0 25658.1 20062.1 29662.6 25513.8 22469.8 22212.0 19750.6 24710.7 19596.9 22410.199999999997 True False 24232.12551951238 21600.798560181152 27754.14061019696 22038.77642624007 19646.942841439293 25271.501379539604 20669.04203507145 24782.604045923395 23516.827583135564 21763.159297307742 1.113447050057207 0.9925396522210507 1.2752808648342864 1.012664389630527 0.9027615234094142 1.161205550825788 0.9497261749873033 1.1387411040541886 1.0805796742040463 1.0 14.409600383367184 S(ph)LYSFIK ddPTM_A459_Selumetinib_30min_R1 1 SLYSFIK 7 0 P09525;Q6P452;P09525-2 P09525 ANXA4 Annexin A4;Annexin 1 S(1)LYSFIK 88.948 0.038324 0.0 2366.0 1745.9 3114.3 1857.8 3581.5 1637.6 2660.8 3714.6 1569.6 3342.4 True False 2421.123196565418 1541.4892163531104 2691.395165625387 1533.3701052251063 3257.553957365184 1621.1272308218345 2460.093713777631 3616.0767412787063 2663.496560951733 3771.429597733032 0.6419643092425033 0.408728090080134 0.7136273118403582 0.40657529604869186 0.863745132435527 0.42984422453392146 0.6522973981156557 0.9588079659374507 0.7062299565535397 1.0 11.880895779670615 -7.998349843866986 0.6408061297893587 0.9856252785861196 0.5545547249588284 0.41356298289685645 0.15858056845913707 0.6608073179847804 0.5861427854080329 0.14561728409797262 0.07087397040293147 1.0038068526390467e-08 7.998349843866986 -0.4310705536272912 S(ph)LYSFIK ddPTM_A459_Selumetinib_30min_R2 1 SLYSFIK 7 0 P09525;Q6P452;P09525-2 P09525 ANXA4 Annexin A4;Annexin 1 S(1)LYSFIK 88.37 0.032367 2266000.0 20708.0 13587.0 12781.0 23218.0 18228.0 15589.0 25346.0 23641.0 24735.0 9276.6 True False 19557.132260692026 14629.079210909184 11958.68437490062 20055.66834671599 15938.035679612445 17736.243247147617 26524.639222146194 23709.79139602176 29682.691153644613 9008.760454498619 2.1709015751357854 1.623872594326115 1.3274505893792443 2.226240607463481 1.769170771063584 1.9687773181149286 2.944316186018781 2.6318594567782103 3.294869622026885 1.0 13.137112899117072 -5.904816350702907 6.378890589640001 2.3364569270415454 1.700433486485874 0.1341720249809233 0.631399318981398 0.3886986219176495 21.86575781708727 0.18149436667479646 0.27146608848694 1.2450409886289389e-06 5.904816350702907 -0.6360234405556715 S(ph)LYYYIQQDTK ddPTM_A459_Selumetinib_30min_R2 3 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 1 S(1)LYYYIQQDTK;S(0.999)LY(0.001)YYIQQDTK;S(0.998)LYYYIQQDT(0.002)K 176.87 3.8988e-08 7415500.0 54153.0 22162.1 28453.4 58142.0 37231.0 35207.9 61408.0 57771.0 43264.7 27258.0 True False 51143.3930516349 23861.861807616868 26622.739221719556 50222.9592994556 32553.70893063698 40057.468639505365 64263.593677643585 57939.104045496126 51918.848916720766 26470.990715210686 1.9320543610121486 0.9014344066051684 1.0057326341934634 1.8972829479554245 1.2297880831460932 1.5132591398057367 2.4276988484876245 2.188777317359842 1.9613489149420955 1.0 14.692124570347032 -7.0649293899001835 8.212726190753092 1.9923795629523162 1.372155082418069 0.19474179252589308 0.46683117590131534 0.4477229245803217 52.52712456468887 0.17296864327378392 0.1342870394577488 8.611337488913823e-08 7.0649293899001835 -0.6202244805342472 S(ph)MDEFTASTPADLGEAGR ddPTM_A459_Selumetinib_30min_R1 1 SMDEFTASTPADLGEAGR 18 0 Q7Z5K2;Q7Z5K2-2;Q7Z5K2-3 Q7Z5K2 WAPAL Wings apart-like protein homolog 1 S(1)MDEFTASTPADLGEAGR 204.9 4.4281000000000003e-11 3203300.0 476.7 532.04 389.27 456.55 529.5 351.8 484.54 363.98 281.91 345.13 True False 487.8061825032687 469.74850946131426 336.4092721070526 376.82211300491014 481.6068184908179 348.261211408843 447.99075769460825 354.32606802633484 478.3806801082467 389.4307973508861 1.252613264851121 1.2062438632403796 0.8638486591083346 0.9676227857895501 1.2366942259496725 0.8942826653102416 1.1503732132694124 0.9098563093536717 1.2284099854517019 1.0 8.605223170978475 -5.069118188051375 10.06201491527293 1.0325802168253084 1.2411461754099171 0.28223206019468916 0.12726315068916558 0.5866891383458082 83.36935130226384 0.030574057336889563 0.08133674580181871 8.528679846071991e-06 5.069118188051375 0.2085659585846087 S(ph)MDELNHDFQALALEGR ddPTM_A459_Selumetinib_30min_R1 3 SMDELNHDFQALALEGR 17 0 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2;E9PR38;Q14671-4 Q5T1Z4 PUM1 Pumilio homolog 1 1 S(1)MDELNHDFQALALEGR;S(1)MDELNHDFQALALEGR;S(1)MDELNHDFQALALEGR 205.84 4.161399999999999e-09 7746100.0 2333.67 3029.7799999999997 3160.52 3492.54 2901.9299999999994 2362.22 3295.3900000000003 2741.41 1345.92 2491.33 True False 2388.039970468647 2675.0519490934894 2731.3387434936744 2882.633452095433 2639.450943877355 2338.4582115241515 3046.8160791662913 2668.6989014453375 2283.927937892557 2811.116473109213 0.8494987643921329 0.9515976924765303 0.9716206246241725 1.0254407740377685 0.9389333274256014 0.8318610181732237 1.0838455497350434 0.9493377193630274 0.8124629341189967 1.0 11.456927514864123 -5.297388210965058 0.00368525055467649 1.8768021976696763 6.418149621251375e-08 0.015948768707460093 0.08236729554152095 352061.22277490015 241.19016442669525 60045.98684161623 62803.34094857957 5.042103880528926e-06 5.297388210965058 -1.8768021334881801 S(ph)MDELNHDFQALALEGR ddPTM_A459_Selumetinib_30min_R2 2 SMDELNHDFQALALEGR 17 0 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2;E9PR38;Q14671-4 Q5T1Z4 PUM1 Pumilio homolog 1 1 S(1)MDELNHDFQALALEGR;S(1)MDELNHDFQALALEGR 116.04 0.0010832 5740400.0 13285.6 10251.8 12984.8 10999.099999999999 15038.7 10293.1 9659.6 10294.0 10992.9 11928.4 True False 12547.23953847064 11038.08009526745 12149.372104781281 9501.00360549417 13149.4040583162 11710.881093541297 10108.79054013428 10323.953835736555 13191.787167289263 11583.996098294781 1.083152949293349 0.9528732573461681 1.0488066468331878 0.8201835985504832 1.1351354011809323 1.0109534735828505 0.8726514109947207 0.8912255967745266 1.1387941652735152 1.0 13.49984540115678 S(ph)MDLGIADETK ddPTM_A459_Selumetinib_30min_R1 6 SMDLGIADETK 11 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-4;Q8TEW0-8 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(1)MDLGIADETK;S(1)MDLGIADETK;S(1)MDLGIADETK;S(0.999)MDLGIADET(0.001)K;S(1)MDLGIADETK;S(1)MDLGIADETK 205.31 1.742e-05 302256000.0 27765.899999999998 32705.999999999996 31010.399999999998 31096.0 26772.499999999996 27813.8 28308.899999999994 28103.9 16785.6 25719.5 True False 28412.791446963525 28876.76631539311 26799.35800793421 25665.667344213543 24350.932102068793 27534.018424909802 26173.536881373846 27358.493277667196 28483.93722828201 29020.848354145124 0.9790475833179857 0.9950352230577907 0.9234519157020572 0.8843872181478681 0.83908408895947 0.9487668344118908 0.9018873797889996 0.9427185912626675 0.9814991236882148 1.0 14.824802073262473 -9.76511357489591 8.050329092680213 1.0000002642747008 0.9300872095978676 0.15965315289353754 0.04579993717652136 0.0 0.0 0.048434939675174656 0.01174719836771557 1.717459185603662e-10 9.76511357489591 -0.06991305467683318 S(ph)MDLGIADETK ddPTM_A459_Selumetinib_30min_R2 3 SMDLGIADETK 11 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-4;Q8TEW0-8 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(1)MDLGIADETK;S(1)MDLGIADETK;S(1)MDLGIADETK 169.09 0.00044143 136582000.0 904030.0 838060.0 818780.0 839490.0 922230.0 664000.0 735550.0 765990.0 554843.0 775130.0 True False 853787.6317188238 902336.5072123746 766100.5862202594 725150.0137989734 806371.222559193 755459.9728081358 769754.5324646747 768218.9040835296 665827.1036087183 752749.9828703977 1.13422471092347 1.1987200634287247 1.0177357737013197 0.9633344806383393 1.071233797288611 1.0036001195608193 1.0225899036615516 1.0205498791964704 0.8845262288413162 1.0 19.52181124455675 -5.311228624501273 6.224963005895506 1.0004937897551247 1.1663352288747102 0.6637541458324309 0.047992784008503944 0.11121421691065209 10.525093637103263 0.012384427797345459 0.02664103880788234 4.883951870643838e-06 5.311228624501273 0.1658414391195855 S(ph)MDLVADETK ddPTM_A459_Selumetinib_30min_R2 2 SMDLVADETK 10 0 F5GZI3 F5GZI3 PARD3 1 S(1)MDLVADETK;S(1)MDLVADETK 158.34 0.00047709 17361200.0 87021.0 82839.0 82556.0 84162.0 81680.0 67656.0 71769.0 75201.0 56885.0 69912.0 True False 82184.72119266384 89192.4849306327 77244.43684017668 72698.99041245217 71418.62817153528 76974.9998799807 75106.40070757558 75419.82245980435 68263.58949969975 67893.45890680948 1.2104954220327844 1.3137124896384826 1.1377301743633705 1.0707804784587387 1.0519220749905296 1.1337616483148478 1.1062391269631229 1.1108555032278669 1.0054516384766656 1.0 16.05098496643064 -1.522878745411475 0.27673246678369073 1.0321451136995108 2.861733675552439 0.6243149324357313 0.055068567815975154 35.716060098869086 0.5020420439128724 0.06550982288074293 31.469979487190038 0.02999999999094135 1.522878745411475 1.8295885618529282 S(ph)MDLVPDESK ddPTM_A459_Selumetinib_30min_R2 1 SMDLVPDESK 10 0 A0A087WZG6;A0A087X1S9;Q8TEW8-5;Q8TEW8-2;Q8TEW8;R4GN62;A0A087WYL6;Q8TEW8-6;Q8TEW8-3 A0A087WZG6 PARD3B Partitioning defective 3 homolog B 1 S(1)MDLVPDESK 98.182 0.019835 1571200.0 17062.0 11538.0 13307.0 16294.0 18095.0 11840.0 10134.0 11586.0 12006.0 12704.0 True False 16113.762344597626 12422.92749948261 12450.84210756612 14074.72909128221 15821.744328647526 13470.852527181216 10605.251080140044 11619.71334183445 14407.535475668372 12337.202511043966 1.3061115216494967 1.0069484948765253 1.0092111316500176 1.1408363507596517 1.2824418108144275 1.0918887418053187 0.8596155466076267 0.9418434472022942 1.16781218941418 1.0 13.59072767671209 -7.014523208081849 24.659457608379636 0.9857972180626315 1.138398721285435 0.287280969460439 0.11577367983188613 792.3395739464012 1345339.6758265458 0.0446636428398386 0.03597145937115353 9.671120441715761e-08 7.014523208081849 0.15260150322280341 S(ph)MDSSDLSDGAVTLQEYLELKK ddPTM_A459_Selumetinib_30min_R1 3 SMDSSDLSDGAVTLQEYLELKK 22 1 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QLH1 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 S(0.788)MDS(0.142)S(0.038)DLS(0.028)DGAVT(0.004)LQEYLELKK;S(0.608)MDS(0.196)S(0.196)DLS(0.001)DGAVTLQEYLELKK;S(0.941)MDS(0.058)S(0.002)DLSDGAVTLQEYLELKK 241.36 5.268899999999999e-37 104410000.0 9118.2 9510.400000000001 11829.7 12317.9 10986.7 9135.599999999999 10665.5 9979.5 5403.9 8211.0 True False 9330.63631907134 8396.91794673499 10223.291715890777 10166.81000062027 9992.954924859432 9043.704158461127 9860.992748156685 9714.811242015512 9170.023614759857 9264.961831912975 1.007088478975936 0.9063089626351157 1.1034359235757296 1.0973396528845802 1.0785748615217063 0.9761188791205021 1.0643317184740786 1.0485538330609243 0.9897529834579453 1.0 13.177569317576982 -5.259447708434606 24.988866260899535 1.0478300890519552 0.9566987228881731 0.3526237330454518 0.047584346925553536 180.78039257874627 2268151.3913770947 0.012398776787928998 0.029638692236696223 5.502401686184283e-06 5.259447708434606 -0.09113136616378203 S(ph)MGETESGDAFLDLK ddPTM_A459_Selumetinib_30min_R1 2 SMGETESGDAFLDLK 15 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B1AKL5;B1AKL6 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(1)MGETESGDAFLDLK;S(1)MGETESGDAFLDLK 149.6 0.00028199 8464400.0 2864.3 3238.1 2691.4 3288.3 3092.8 2929.7 2702.8 2747.8999999999996 1794.1599999999999 2407.0 True False 2931.032617042403 2858.9817466481513 2325.922662801967 2714.0601340358044 2813.0567860781894 2900.229877954765 2498.9256199632373 2675.0167655628466 3044.5584797382553 2715.961896165451 1.0791876797611193 1.0526590047837652 0.8563900200830639 0.9992997832067042 1.0357497246370881 1.0678463059623458 0.9200886151942567 0.9849242617650811 1.120987184701205 1.0 11.407247523965365 -6.011220800286026 24.759325797488643 1.0180316845095647 0.9894216078912818 0.02281285829443702 0.07359596984290742 2271.52214948681 5012260.7983344495 0.02226534928924446 0.030577258657000735 9.744940678121177e-07 6.011220800286026 -0.028610076618282965 S(ph)MGFLSIK ddPTM_A459_Selumetinib_30min_R1 2 SMGFLSIK 8 0 Q12923-3;Q12923;Q12923-4;Q12923-2 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 S(1)MGFLSIK;S(1)MGFLSIK 112.11 0.011314 12571200.0 3131.3999999999996 4034.5 2941.8999999999996 3335.6 3422.0 3436.5 3412.3 3526.6 2418.6 3340.7 True False 3204.355527356274 3562.138864411837 2542.406138699972 2753.100076966769 3112.4807042031703 3401.9319300923494 3154.9074637415074 3433.063111988767 4104.187552445124 3769.5113861736277 0.8500718525774146 0.9449868960411096 0.674465700786947 0.730359931280483 0.8256987140613471 0.9024861796599049 0.8369539551766694 0.9107448579625106 1.0887850259582903 1.0 11.880161814408263 -8.009769587035937 2.5641432487923357 1.0440514716526166 0.8208967045520152 0.568225711787321 0.07602837138556841 0.22887843233997163 2.8414505637216156 0.06457642907938221 0.022414315322675904 9.777558272830518e-09 8.009769587035937 -0.22315476710060134 S(ph)MGFLSIK ddPTM_A459_Selumetinib_30min_R2 1 SMGFLSIK 8 0 Q12923-3;Q12923;Q12923-4;Q12923-2 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 S(1)MGFLSIK 85.355 0.03539 3605900.0 12902.0 9234.7 12976.0 13698.0 10530.0 12439.0 12881.0 13247.0 9332.9 10851.0 True False 12184.958490798179 9942.971795759402 12141.138287200574 11832.30876963199 9207.127260605603 14152.359340000592 13479.992023217279 13285.5465768411 11199.740783013945 10537.703435716163 1.1563201190022925 0.9435615508080256 1.1521616983497351 1.1228545993738952 0.8737318635670893 1.343021221496235 1.2792153532740933 1.2607629981131832 1.062825581620934 1.0 13.363272862946063 -6.772354603569179 24.999996006597442 1.2110908252840786 1.053581497708459 0.22316470809424382 0.1267194793530342 294.0720060189965 673532.3400901944 0.043431160587470215 0.03866880567144072 1.68906124169086e-07 6.772354603569179 -0.15750932757561964 S(ph)MGNLLEK ddPTM_A459_Selumetinib_30min_R2 1 SMGNLLEK 8 0 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 S(1)MGNLLEK 81.625 0.043279000000000005 2542500.0 18586.0 15696.0 15883.0 15479.0 18035.0 14894.0 16398.0 16962.0 15944.0 15897.0 True False 17553.064525652997 16899.83272940536 14861.105072102864 13370.733497235631 15769.282065054325 16945.51330572948 17160.539492020573 17011.356611789735 19133.245512581747 15438.012304633663 1.1370028847809965 1.094689678692181 0.9626307311364403 0.8660916466054671 1.021458057804581 1.0976486461695167 1.1115770057308414 1.1019136580610083 1.2393593899934239 1.0 13.914199392333625 -6.799737093240682 3.895513530656846 1.1191233370175575 1.008587004519193 0.2243217867976307 0.08683032701128207 0.33535284374013724 10.750804632652414 0.03337455245094952 0.030362242906603085 1.5858529220856809e-07 6.799737093240682 -0.11053633249836459 S(ph)MGYDDLDYGMMSDYGTAR ddPTM_A459_Selumetinib_30min_R1 4 SMGYDDLDYGMMSDYGTAR 19 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 S(0.953)MGY(0.047)DDLDYGMMSDYGTAR;S(0.998)MGY(0.002)DDLDYGMMSDYGTAR;S(1)MGYDDLDYGMMSDYGTAR;S(1)MGYDDLDYGMMSDYGTAR 366.33 2.5138999999999978e-217 236160000.0 4985.91 5349.73 4489.32 3879.5400000000004 4627.46 4200.0 4709.67 4641.99 2364.92 4481.32 True False 5102.072002107977 4723.381124577996 3879.6950020696017 3202.0511669851508 4208.90706004442 4157.751813294884 4354.415800122929 4518.869345891437 4013.0965130772042 5056.541073753286 1.0090043624071454 0.9341130736770626 0.7672626298256974 0.6332493141617823 0.832368806789955 0.8222521586695503 0.8611451457845679 0.8936680786293396 0.793644599053643 1.0 12.303935131613605 -9.471346139471068 10.517421492011435 1.000000000005583 0.834828932779306 0.20343166658540734 0.09560801944434931 131440160.55308296 0.0 0.10030948945593894 0.02507737236398475 3.377955006089786e-10 9.471346139471068 -0.16517106722627706 S(ph)MGYDDLDYGMMSDYGTAR ddPTM_A459_Selumetinib_30min_R2 8 SMGYDDLDYGMMSDYGTAR 19 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 S(0.876)MGY(0.124)DDLDYGMMSDYGTAR;S(0.931)MGY(0.069)DDLDYGMMSDYGTAR;S(0.883)MGY(0.03)DDLDY(0.046)GMMS(0.04)DYGTAR;S(1)MGYDDLDYGMMSDYGTAR;S(0.997)MGY(0.003)DDLDYGMMSDYGTAR;S(0.998)MGY(0.002)DDLDYGMMSDYGTAR;S(1)MGYDDLDYGMMSDYGTAR;S(0.993)MGY(0.005)DDLDY(0.001)GMMSDYGTAR 287.48 2.824099999999999e-85 31553300.0 89063.62 73830.30000000002 78842.4 76670.40000000001 87694.5 71230.5 84986.41 82063.8 64725.8 80051.2 True False 84113.82055031945 79492.84660816894 73769.76582111456 66227.75925618301 76677.53291122298 81041.85480890049 88938.44646237655 82302.59207160657 77672.76858995634 77739.9138580041 1.0819901434925385 1.0225486839793347 0.9489303777189512 0.8519144924337242 0.9863341635710889 1.0424742038810018 1.1440512607825517 1.0586915779445862 0.9991362832203492 1.0 16.246367888606812 -6.7707113961456535 4.448405885399834 1.0596946747254834 0.9713276595505282 0.2129438520955491 0.06645057822536789 0.2926083809698853 13.913856533574826 0.025393115259941586 0.023560639169566733 1.6954641213020147e-07 6.7707113961456535 -0.08836701517495515 S(ph)MMSPMADR ddPTM_A459_Selumetinib_30min_R2 1 SMMSPMADR 9 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 S(0.635)MMS(0.365)PMADR 115.23 0.0082322 11028000.0 12436.0 15416.0 18389.0 20868.0 21193.0 12409.0 14784.0 16739.0 14116.0 15277.0 True False 11744.856905252365 16598.35762974726 17205.87176042936 18025.742400692096 18530.545872176117 14118.227112313485 15471.485293940248 16787.70771870938 16939.594433994225 14835.913315587124 0.7916504131169877 1.1187958082977238 1.159744694811089 1.215007260911509 1.2490330374677563 0.9516250743714165 1.0428400978647785 1.1315587629560784 1.14179653612541 1.0 13.856806123038334 -4.761369551022444 24.280044578044578 1.1181566640283573 0.7916501507285867 0.5470484715963297 0.08737473849874276 0.925962954727078 318606.32666651683 0.02296864041590428 0.12834575383310748 1.7323292921369916e-05 4.761369551022444 -0.32650651329977065 S(ph)MPAETIK ddPTM_A459_Selumetinib_30min_R1 4 SMPAETIK 8 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(1)MPAETIK;S(1)MPAETIK;S(1)MPAETIK;S(1)MPAETIK 142.0 0.0022429000000000004 498769000.0 21727.4 23330.5 25886.9 26870.600000000002 25820.5 21995.9 23884.8 24098.300000000003 12840.7 19510.5 True False 22233.60614583915 20598.954213944813 22371.601166563232 22178.15413363212 23485.04033397954 21774.641216679283 22083.150306237192 23459.134801689732 21789.730052378287 22014.862723363556 1.009936170178497 0.9356839728136895 1.0162044364156348 1.0074173258457464 1.066781139137231 0.9890882123725744 1.0031018854730884 1.0656044099150082 0.9897736055039605 1.0 14.426190227733404 -5.399179887588753 8.805351854179392 1.0197517825929883 0.9729104876221757 0.24283007868433049 0.031193644758167504 0.37728638732870273 25.302554555840228 0.007783183604475291 0.01623894257618638 3.988596578868206e-06 5.399179887588753 -0.046841294970812575 S(ph)MPAETIK ddPTM_A459_Selumetinib_30min_R2 5 SMPAETIK 8 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(1)MPAETIK;S(1)MPAETIK;S(1)MPAETIK;S(1)MPAETIK;S(1)MPAETIK 162.64 0.00036287 570502100.0 765680.0 668455.0 794652.0 815283.0 788759.0 555669.0 657140.0 708346.0 542386.0 596819.0 True False 723126.570859894 719723.3490784048 743524.9554716783 704240.0489583801 689668.0428250722 632207.3608890416 687698.3120982074 710407.1695870075 650878.3555310583 579587.284748012 1.2476577555946364 1.2417859535881985 1.2828524279909657 1.2150715992062586 1.189929560178188 1.0907888725749173 1.186531054416073 1.2257121373804332 1.1230031656302495 1.0 19.144666419172566 -14.52287874527992 0.08009792159540198 0.32416225958509937 1.4039210325297016 0.7281533027739588 0.0423709231694529 146.11084056735362 0.8253997388762869 17.358299467695204 1.6064248633879532 3.0000000000028847e-15 14.52287874527992 1.079758772944602 S(ph)MPVDER ddPTM_A459_Selumetinib_30min_R1 1 SMPVDER 7 0 P55042 P55042 RRAD GTP-binding protein RAD 1 S(1)MPVDER 126.24 0.005767100000000001 23813000.0 4389.7 4917.8 4206.3 5134.2 5267.2 4329.4 4560.4 4021.5 2435.6 3698.3 True False 4491.97146913069 4342.021689776808 3635.1075635520224 4237.608350870244 4790.782689999693 4285.850166780681 4216.405356400896 3914.8367563270094 4133.035310814247 4173.012829492601 1.0764336590062369 1.040500441093721 0.871099062495338 1.0154793488582439 1.1480392909748631 1.0270397772301603 1.0103983689198415 0.9381319723387999 0.9904199866351203 1.0 12.02687364068561 -7.565772196305285 7.9447577424514755 0.973135576055301 1.0270457498210375 0.11425099438805808 0.06630224838648056 0.5962383686312341 95.22817145578178 0.03390134571468286 0.019558389877482346 2.7178645165727307e-08 7.565772196305285 0.05391017376573648 S(ph)MPVDER ddPTM_A459_Selumetinib_30min_R2 2 SMPVDER 7 0 P55042 P55042 RRAD GTP-binding protein RAD 1 S(1)MPVDER;S(1)MPVDER 112.11 0.014704 68755000.0 207189.0 194045.0 209688.0 245713.0 199205.0 149389.0 180116.0 149245.0 158373.0 179778.0 True False 195674.26482328182 208927.6275469846 196196.90237103237 212246.46552143237 174179.08698470474 169965.97873167868 188491.75089308314 149679.2782411602 190052.02531134654 174587.34202065968 1.1207815100371183 1.1966940164669055 1.1237750692591193 1.2157036304288105 0.9976616000264977 0.9735297918194199 1.079641563423184 0.8573317888272107 1.0885784909243699 1.0 17.413589438524383 -6.273478628920646 24.260772457780966 0.9950366262006625 1.163666551985979 0.6043014124177595 0.06526400158408331 317.1067636057871 639013.2242437362 0.018826539217259707 0.02152788682223852 5.32747439502187e-07 6.273478628920646 0.16862992578531655 S(ph)MPVDERDLQAALTPGALTAAAAGTGTQGPR ddPTM_A459_Selumetinib_30min_R1 1 SMPVDERDLQAALTPGALTAAAAGTGTQGPR 31 1 P55042 P55042 RRAD GTP-binding protein RAD 1 S(1)MPVDERDLQAALTPGALTAAAAGTGTQGPR 119.51 2.8008e-16 9705400.0 252.32 291.06 662.62 528.2 387.2 398.06 367.1 518.09 119.73 160.67 True False 258.1985650707464 256.9825598898769 572.6398435111244 435.9597855419857 352.17782836571246 394.05587780956233 339.4093514460945 504.3485702065056 203.17306526678846 181.29355955833122 1.4242015309301208 1.4174941488045123 3.1586331301905815 2.404717446135838 1.942583229231589 2.1735790216131465 1.8721533863252846 2.781944220386005 1.1206855100741595 1.0 7.50218386412157 -8.364017700241213 7.204175129148719 1.0207467878881764 2.148707003897847 0.4147018965237581 0.5167286383689365 0.28140798850193394 16.97857213856757 0.5122373071667137 0.13261424218883952 4.324962037257717e-09 8.364017700241213 1.1279602160096704 S(ph)MPVLGSVSSVTK ddPTM_A459_Selumetinib_30min_R1 2 SMPVLGSVSSVTK 13 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 S(1)MPVLGSVSSVTK;S(1)MPVLGSVSSVTK 198.23 0.00015529 122655000.0 3252.6000000000004 3687.2000000000003 4010.3999999999996 4492.4 4028.2000000000003 3178.8999999999996 3461.7 3873.8 2093.29 3179.3 True False 3328.3792515421287 3255.500909867225 3465.8097075503492 3707.8866727921563 3663.8500212364715 3146.9231522102623 3200.581181969341 3771.054240124228 3552.1602421474618 3587.394124004494 0.9277986015728779 0.9074834816959595 0.9661078732217958 1.033587764439208 1.0213123773382982 0.877217011410347 0.8921743949328416 1.0511959683745926 0.9901784190308864 1.0 11.80872053832423 -5.344992257075775 5.195365911112657 0.9780867660643875 0.9178845296185265 0.17512629109264732 0.05360663750090107 0.40409344388742846 18.36983331963007 0.015537240100044465 0.03366170248384088 4.518640004697436e-06 5.344992257075775 -0.06020223644586098 S(ph)MSAAFCSLLAPER ddPTM_A459_Selumetinib_30min_R1 1 SMSAAFCSLLAPER 14 0 E9PNR2;Q13671-2;Q13671 E9PNR2 RIN1 Ras and Rab interactor 1 1 S(0.574)MS(0.425)AAFCS(0.001)LLAPER 200.63 6.801100000000001e-05 76171000.0 1352.5 1760.7 1724.4 1729.2 1913.0 1416.4 1553.7 1442.5 722.9 1348.4 True False 1384.010618493122 1554.556425472776 1490.2359514511825 1427.2276811041304 1739.9694877675809 1402.152301988304 1436.503158108953 1404.2402140996435 1226.708501472993 1521.4802745282495 0.9096474280103621 1.021739454331593 0.9794645230699723 0.9380520437878545 1.1436030534849202 0.9215711340214751 0.944148394269755 0.9229434239855936 0.8062598786259957 1.0 10.571259914587717 -6.957386236224135 24.999947452469314 0.9149077271973084 0.99909750381024 0.227714688775288 0.07312487193194306 205.1588286907523 120358.58918842358 0.025209587052259015 0.02223274295648278 1.1030971531601225e-07 6.957386236224135 0.08418977661293159 S(ph)MSAAFCSLLAPER ddPTM_A459_Selumetinib_30min_R2 1 SMSAAFCSLLAPER 14 0 E9PNR2;Q13671-2;Q13671 E9PNR2 RIN1 Ras and Rab interactor 1 1 S(0.781)MS(0.219)AAFCSLLAPER 123.68 0.0015932 18754000.0 13225.0 8761.1 10013.0 9075.5 10584.0 9401.9 7584.5 7744.2 7920.7 8852.5 True False 12490.007443869616 9433.048198623419 9368.774481330103 7839.401243889266 9254.343297839485 10696.92638304941 7937.194278401635 7766.734339878679 9505.061322849111 8596.905323442752 1.4528492491141936 1.0972609146806123 1.089784536277555 0.9118864229564259 1.0764737948903516 1.2442763972147217 0.923261799424246 0.9034337412905672 1.105637548075576 1.0 13.069601702847411 -4.575451451677641 1.9166194131557335 1.02865288657771 1.7931235196064061 0.6122650106782208 0.09991483511082881 1.1254404351972531 2.722872288871862 0.02796737159341731 1.84641119920313 2.6579606574477154e-05 4.575451451677641 0.7644706330286961 S(ph)MSAPVIFDR ddPTM_A459_Selumetinib_30min_R2 1 SMSAPVIFDR 10 0 O60749;D6RC15 O60749 SNX2 Sorting nexin-2 1 S(0.722)MS(0.278)APVIFDR 111.5 0.008813 2624200.0 14765.0 11314.0 14871.0 12406.0 15373.0 11031.0 10578.0 8393.7 10010.0 11926.0 True False 13944.420408978069 12181.747419756133 13914.216050320576 10716.2813984563 13441.706303636276 12550.420120552015 11069.897959909355 8418.124277348164 12012.279702768654 11581.665392530735 1.204008226482793 1.0518131034602678 1.2014002804203059 0.9252798311171605 1.160602197358 1.0836455462308598 0.9558122761039678 0.7268492045001744 1.0371806899649882 1.0 13.499555100993303 -7.31731569850304 3.908353494172993 0.9011601424633329 1.1018607158628686 0.380969290602853 0.10821442011351473 0.21904802225900424 6.8873094000817625 0.04497719158907809 0.030016150893200762 4.815975861504833e-08 7.31731569850304 0.20070057339953573 S(ph)MSDVSAEDVQNLR ddPTM_A459_Selumetinib_30min_R1 2 SMSDVSAEDVQNLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.947)MS(0.053)DVSAEDVQNLR;S(1)MSDVSAEDVQNLR 209.53 5.112e-06 14117100.0 2614.71 3109.1000000000004 2539.31 2990.9 3206.8 2776.0699999999997 3347.3 2849.89 1509.17 2278.05 True False 2675.627655660001 2745.0851266186246 2194.485649431397 2468.595461146394 2916.745506206524 2748.1452562698887 3094.810466073308 2774.301659452637 2560.9512645843083 2570.4599075860865 1.0409139810986887 1.0679353988432865 0.8537326892183407 0.9603711203045554 1.1347173700700253 1.0691258977272537 1.2039909500007093 1.0793016655365686 0.9963008008902547 1.0 11.327810794677651 -6.252799674533223 24.71899866065582 1.090136428502184 0.9778948270655331 0.2792460647503512 0.07761500312632728 694.3370949221069 1986561.55540238 0.023945077749569197 0.0303902100265463 5.587278577128728e-07 6.252799674533223 -0.11224160143665085 S(ph)MSDVSAEDVQNLR ddPTM_A459_Selumetinib_30min_R2 3 SMSDVSAEDVQNLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.962)MS(0.038)DVSAEDVQNLR;S(0.998)MS(0.001)DVSAEDVQNLR;S(1)MSDVSAEDVQNLR 293.41 6.881599999999997e-67 18847100.0 58814.0 55615.0 58135.0 61302.0 64688.0 55836.0 46870.0 58521.0 46542.0 55550.0 True False 55545.35333109626 59880.49166958962 54394.65739260212 52952.561848151585 56561.31512194256 63526.90217125764 49049.54787114307 58691.28642132694 55851.7004921337 53946.12716376676 1.0296448744591924 1.110005385332067 1.0083144101795063 0.9815822679429987 1.0484777702435757 1.1775989401130889 0.909232051491687 1.0879610735197929 1.0353236354220963 1.0 15.71923177073295 -14.522878718523948 0.2675698424594468 0.7043179567102855 1.0469162194919102 0.03456734570612907 0.06908639994281437 905.9269377266631 8.813971082652415 147.79962336741764 0.08536207404876041 3.0000001848265948e-15 14.522878718523948 0.34259826278162464 S(ph)MSENAVR ddPTM_A459_Selumetinib_30min_R1 2 SMSENAVR 8 0 A0A0A0MS29;Q9GZY8-2;C9JHF5;H7C433;Q9GZY8-4;Q9GZY8-3;Q9GZY8;Q9GZY8-5 A0A0A0MS29;Q9GZY8-5 MFF Mitochondrial fission factor 1 S(0.5)MS(0.5)ENAVR;S(0.711)MS(0.289)ENAVR 138.22 0.0043096 166846000.0 12639.599999999999 15281.0 15144.1 14262.599999999999 12813.9 16369.7 12107.4 15817.9 7012.6 11249.6 True False 12934.078087619719 13491.893416055835 13087.614400586792 11771.90465216041 11654.885007477784 16205.035680498406 11194.129070276333 15398.357908219572 11899.870019960581 12693.595740383416 1.0189451714198863 1.0628897982888106 1.0310407443455794 0.9273892829838013 0.9181704889497089 1.2766308311634418 0.8818721896635893 1.2130808498360495 0.9374703798154155 1.0 13.631813181747008 S(ph)MSENAVR ddPTM_A459_Selumetinib_30min_R2 2 SMSENAVR 8 0 A0A0A0MS29;Q9GZY8-2;C9JHF5;H7C433;Q9GZY8-4;Q9GZY8-3;Q9GZY8;Q9GZY8-5 A0A0A0MS29;Q9GZY8-5 MFF Mitochondrial fission factor 1 S(0.968)MS(0.032)ENAVR;S(0.694)MS(0.306)ENAVR 123.11 0.0060721 377400000.0 598960.0 286880.0 419890.0 613900.0 337760.0 360700.0 808520.0 444720.0 489880.0 382010.0 True False 565672.2010268545 308882.77353541047 392874.73454166594 530285.7609634314 295327.56918728893 410383.1508914075 846117.7820519872 446014.06157264055 587869.68839084 370980.37871882063 1.5248035569439045 0.832612157554359 1.0590175574742184 1.4294172721338292 0.7960732861592346 1.106212550401356 2.2807615458641015 1.2022578205158678 1.5846382237816614 1.0 18.50098335865853 S(ph)MSFQGIR ddPTM_A459_Selumetinib_30min_R1 1 SMSFQGIR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 S(0.947)MS(0.053)FQGIR 112.3 0.011233 3820800.0 2012.5 2387.5 2101.2 2461.3 2702.0 2064.1 2568.8 2479.5 868.55 1923.1 True False 2059.387334356678 2107.970390081362 1815.8685810654285 2031.4801593231534 2457.604577076847 2043.3370280528493 2375.0333478472544 2413.7356054489182 1473.8659136178824 2169.9486175802986 0.9490488934494186 0.9714379285312073 0.8368256125300776 0.936188139601411 1.1325634889075449 0.9416522637901752 1.0945113301787048 1.1123468942506416 0.6792169647138394 1.0 11.083445166023205 -6.023333485913645 24.652304086194096 1.0044606814549502 0.9180323951413506 0.0670890581679916 0.1250263450311485 1574.4719269418451 1663461.4812723428 0.03607897162165079 0.04690376494649869 9.476904715628111e-07 6.023333485913645 -0.08642828631359956 S(ph)MSFQGIR ddPTM_A459_Selumetinib_30min_R2 1 SMSFQGIR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 S(0.707)MS(0.293)FQGIR 112.3 0.011233 29296000.0 44935.0 32687.0 60573.0 52916.0 48695.0 28278.0 30432.0 30197.0 25655.0 52783.0 True False 42437.6925890572 35193.9877947294 56675.799126895836 45708.74951480846 42577.498761176634 32173.037817874196 31847.14829986401 30284.868270617546 30786.71686059238 51259.01764329615 0.8279068647857196 0.6865911485007204 1.105674703352574 0.8917211373984735 0.8306343101903959 0.6276561529477908 0.6212984517472332 0.5908203017343294 0.6006107466754932 1.0 15.645518209823003 -6.664158574094053 4.483639040345713 0.6584944467553208 0.8782403774404405 0.26376144962995973 0.1478388776679523 0.256868402997258 9.082219504489666 0.04945398624647244 0.04892843506611667 2.1669127547535784e-07 6.664158574094053 0.21974593068511972 S(ph)MSIDDTPR ddPTM_A459_Selumetinib_30min_R1 1 SMSIDDTPR 9 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7;A0A0C4DGY6;A0A1B0GVW2 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 S(1)MSIDDTPR 193.83 0.0019004 43919000.0 2784.0 3545.8 3572.7 3390.6 3428.3 2863.5 3145.6 2854.6 1593.5 2270.2 True False 2848.861783279004 3130.656087602302 3087.546963436348 2798.495359444635 3118.210870315525 2834.695789849976 2908.324859462912 2778.886734952402 2704.053115364799 2561.6022836206093 1.1121405541739202 1.2221476017648543 1.2053186332549486 1.0924784762016988 1.2172892295786824 1.1066104242549986 1.1353537893291692 1.0848236483552316 1.0556100502623098 1.0 11.322830783765161 -8.034645557290572 0.6458266442707692 0.9988082906860488 1.1742002212175215 0.6236146216516577 0.04254688317209437 0.4410565287136019 0.40029131905086995 0.0397907326796625 0.019009673274103186 9.23324676859026e-09 8.034645557290572 0.17539193053147273 S(ph)MSIDDTPR ddPTM_A459_Selumetinib_30min_R2 2 SMSIDDTPR 9 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7;A0A0C4DGY6;A0A1B0GVW2 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 S(0.999)MS(0.001)IDDTPR;S(0.999)MS(0.001)IDDTPR 110.84 0.01062 30048000.0 65378.0 69096.0 69823.0 76385.0 90514.0 64407.0 69168.0 70779.0 65012.0 72054.0 True False 61744.55248887016 74395.44102134249 65330.66419753436 65981.23122852521 79142.82211457314 73278.47962146612 72384.44905379189 70984.95517190585 78016.21658705252 69973.6138012251 0.8823976515528934 1.0631927805340813 0.9336471370925614 0.9429444564055088 1.131038084432728 1.0472301720707065 1.0344534907031566 1.0144531819316018 1.1149376507646744 1.0 16.094523381398986 -6.2374941539885 24.854042437979235 1.056123735873248 0.9616704190318699 0.43242137987522544 0.056774266288569394 745.2329685207316 773517.5765768697 0.016185156749532404 0.020881430723283027 5.787697790813379e-07 6.2374941539885 -0.09445331684137814 S(ph)MSLIPTSPQVPGEWPSPEELGAR ddPTM_A459_Selumetinib_30min_R2 1 SMSLIPTSPQVPGEWPSPEELGAR 24 0 M0QZ22;Q5PRF9;A0A087WZT0;M0R0X3 M0QZ22 SAMD4B Protein Smaug homolog 2 1 S(0.328)MS(0.29)LIPT(0.077)S(0.304)PQVPGEWPSPEELGAR 66.828 0.0016219 890960.0 5781.7 3545.0 4425.9 5719.5 6486.3 3906.6 4810.3 3806.6 2961.9 3779.1 True False 5460.376259978903 3816.890101028413 4141.142412555565 4940.4942333121735 5671.433005742277 4444.698689416057 5033.988481428621 3817.6765757834464 3554.3627624006476 3669.9875637190084 1.4878459845366865 1.0400280749617963 1.1283805028372107 1.3461882765361983 1.545354829484787 1.2110936651000501 1.3716636348291578 1.040242373986351 0.9684944977848394 1.0 11.8415594589591 -7.846492151085847 5.589073259103129 0.9929001780290784 1.294355705868859 0.47688893314334946 0.14483086509345683 0.1994391434486573 9.98501592556079 0.08512791945627973 0.040235926131446456 1.423992981943691e-08 7.846492151085847 0.3014555278397807 S(ph)MSPNLLNR ddPTM_A459_Selumetinib_30min_R2 1 SMSPNLLNR 9 0 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;F8VVB8 Q9Y4F3-3;F8VVB8 KIAA0430 Meiosis arrest female protein 1 1 S(0.9)MS(0.1)PNLLNR 139.31 0.0023913 10579000.0 32829.0 28303.0 30029.0 44322.0 44596.0 27968.0 31385.0 38017.0 24460.0 30971.0 True False 31004.495604899494 30473.74909151119 28096.96683310312 38285.26714028537 38993.45178670156 31820.33813177401 32844.464688197666 38127.62317594685 29352.683469502615 30076.786757678132 1.0308446794764248 1.0131982959825891 0.9341744867719424 1.2729174645131178 1.296463352314294 1.0579700015212157 1.0920203994136106 1.267676081329182 0.9759248454959816 1.0 14.876362825009737 -5.746708998561211 24.99991918144118 1.1501269433133383 0.9947850597712339 0.26288535077785746 0.10971620182079657 306.91978364484197 520889.7887498094 0.029704733608471517 0.051169918970935986 1.791806061528364e-06 5.746708998561211 -0.15534188354210443 S(ph)NDRNSMDIQCEVDALLER ddPTM_A459_Selumetinib_30min_R1 1 SNDRNSMDIQCEVDALLER 19 1 Q02241;H7BYN4;A0A2U3TZL8;A0A2R8Y531;H0YME6;Q02241-2 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 S(0.894)NDRNS(0.106)MDIQCEVDALLER 164.82 9.4738e-08 36704000.0 1786.3 1740.3 1944.0 1937.7 1701.8 1993.2 1917.1 1540.2 1031.0 1426.9 True False 1827.9173144652605 1536.5448669564803 1680.015477627637 1599.3170701338622 1547.872490477193 1973.1502176807996 1772.491603533934 1499.3488927253168 1749.5316987393223 1610.0565141830018 1.1353125175191807 0.9543421944640099 1.0434512471011832 0.9933297719958674 0.9613777385091584 1.2255161233778455 1.1008878184834134 0.9312399158150906 1.086627508617047 1.0 10.652895613561364 -4.719085757930715 23.65275480723294 1.0358162504058834 1.1353147854795762 0.11927371223353334 0.08310454851106164 12384.499445551426 6915276.173115629 0.021247910371474634 8.640600486089038 1.909476166753172e-05 4.719085757930715 0.09949853507369277 S(ph)NDRNSMDIQCEVDALLER ddPTM_A459_Selumetinib_30min_R2 1 SNDRNSMDIQCEVDALLER 19 1 Q02241;H7BYN4;A0A2U3TZL8;A0A2R8Y531;H0YME6;Q02241-2 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 S(0.5)NDRNS(0.5)MDIQCEVDALLER 70.414 0.008807299999999999 1693300.0 1295.1 2229.3 929.62 2300.0 2253.5 2519.1 1804.6 2868.4 1162.3 2683.1 True False 1223.1235266960723 2400.280141670705 869.8092612937265 1986.7360322786958 1970.3951834543893 2866.0831588870074 1888.5174757470606 2876.746569110818 1394.7924773754241 2605.6319314689927 0.469415312241167 0.921189256503118 0.3338189292158962 0.7624776194535741 0.7562062621574982 1.0999570293380534 0.724782903118001 1.1040494762009527 0.535299119008368 1.0 11.347417589539893 -6.225210761249707 2.618548552193743 0.8867316622389131 0.6082251521894632 0.26103242519098613 0.21648310375653324 0.3891899050367874 5.279226013419489 0.06552988503837534 0.0848721121357752 5.953731413765244e-07 6.225210761249707 -0.27850651004944993 S(ph)NDSTDGEPEEK ddPTM_A459_Selumetinib_30min_R2 1 SNDSTDGEPEEK 12 0 A0A0A0MTH9;O14981 A0A0A0MTH9 BTAF1 TATA-binding protein-associated factor 172 1 S(0.988)NDS(0.012)TDGEPEEK 98.676 0.016358 0.0 27734.0 21583.0 28266.0 29043.0 25024.0 20688.0 22836.0 22917.0 19567.0 22575.0 True False 26192.65530799848 23238.346699716847 26447.396333693832 25087.29329803051 21880.261402601594 23537.584213034206 23897.919248675553 22983.684675886423 23480.94674765975 21923.201093105923 1.194745931342807 1.05998875807532 1.2063656316143818 1.1443261954076398 0.9980413585442214 1.0736381111988227 1.090074353064736 1.0483726613771738 1.0710546624983375 1.0 14.420170846824716 -1.5228787452807446 0.14259063098904648 0.9869120703288641 1.6278481786574746 0.4430988261865362 0.05130361160556485 75.03049016855508 0.7123521082905094 0.21637599418231956 9.833997962360892 0.029999999999971882 1.5228787452807446 0.6409361083286105 S(ph)NEDQSMGNWQIK ddPTM_A459_Selumetinib_30min_R2 1 SNEDQSMGNWQIK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(1)NEDQSMGNWQIK 134.81 0.0011845999999999998 3323200.0 14556.0 13981.0 13551.0 13587.0 16946.0 12114.0 15873.0 12803.0 8945.5 12966.0 True False 13747.035792284772 15053.297743999516 12679.143413213234 11736.427161117668 14817.091980837844 13782.59354005685 16611.125951752812 12840.254610349255 10734.849958153542 12591.637890286227 1.0917591430174365 1.1954995748100672 1.006949494870283 0.9320810575542116 1.1767406361223613 1.0945830606111522 1.3192188416224553 1.0197445894036408 0.852538013854012 1.0 13.620178337149797 -7.999211399019196 24.999966821517745 0.9295597305795941 1.1141183115045994 0.35125960314239246 0.10440744463082877 28.453028799548363 902015.8871270823 0.05982678794986915 0.02834099239452403 1.0018174704637309e-08 7.999211399019196 0.18455858092500532 S(ph)NEDSLILEK ddPTM_A459_Selumetinib_30min_R2 1 SNEDSLILEK 10 0 A0A0U1RRH6;O94880 A0A0U1RRH6 PHF14 PHD finger protein 14 1 S(1)NEDSLILEK 110.38 0.0094949 1924700.0 13298.0 9141.9 12305.0 12129.0 15629.0 11674.0 13437.0 12706.0 12228.0 10969.0 True False 12558.950396111768 9843.054334158438 11513.309696671013 10477.009276307954 13665.545294967242 13281.987533979174 14061.847124910379 12742.97235640847 14673.94167886664 10652.29646911534 1.1789899419833527 0.9240312042287622 1.0808288832414725 0.9835446569370648 1.2828731658556767 1.2468661168498465 1.320076583080512 1.1962652741927262 1.377537859691704 1.0 13.378876866099317 -6.26491923332273 24.990364559614132 1.2517032541320732 1.0362174357932852 0.4180607401460643 0.11210105767542598 256.2089675086069 1839948.628401223 0.03156874560453569 0.03726733566084703 5.433513703179021e-07 6.26491923332273 -0.215485818338788 S(ph)NEDVNSSELDEEYLIELEK ddPTM_A459_Selumetinib_30min_R1 1 SNEDVNSSELDEEYLIELEK 20 0 Q99614 Q99614 TTC1 Tetratricopeptide repeat protein 1 1 S(0.999)NEDVNS(0.001)SELDEEYLIELEK 93.392 0.00083414 1347100.0 537.52 587.41 443.94 368.21 588.66 369.39 823.62 739.08 481.25 910.12 True False 550.0431701681498 518.6357641205 383.655386387867 303.909035657733 535.4158069363638 365.67427197928515 761.4936802997337 719.4771975298188 816.6461008906866 1026.9427673195262 0.5356122927900301 0.5050288882935674 0.37358984219662483 0.29593570871625197 0.521368691591138 0.3560804785000332 0.741515208571307 0.700601066024119 0.7952206557939492 1.0 10.004140065534267 -7.877222567695258 0.8740823199736203 0.9634387143146647 0.4215359358217704 0.7957542896579073 0.0956306271831492 0.25803823539594034 0.36858871710920466 0.08989651350123481 0.03690994665117835 1.3267143674961772e-08 7.877222567695258 -0.5419027784928943 S(ph)NFSNSADDIK ddPTM_A459_Selumetinib_30min_R1 1 SNFSNSADDIK 11 0 P45973 P45973 CBX5 Chromobox protein homolog 5 1 S(0.994)NFS(0.006)NSADDIK 168.93 0.00045083 24304000.0 2739.3 2556.9 2758.4 2620.8 2386.1 2290.2 2494.3 2158.0 1473.4 1974.0 True False 2803.120360250061 2257.536959329439 2383.824430806623 2163.126478508968 2170.2776763001707 2267.1626673352234 2306.1529428275485 2100.7628298280956 2500.252187121741 2227.382128388285 1.2584820200018285 1.0135382387049023 1.070235951175355 0.9711519415279624 0.9743625256931399 1.017859772887611 1.0353647510390422 0.943153311258805 1.1225070701859776 1.0 11.121133371947266 -4.761334338390561 24.772045801534006 1.0142702633807905 1.2584822853840918 0.6868106051294703 0.04900902095167702 1.1994217401272689 281375.6236121048 0.011546641803149526 0.06468461263587989 1.7324697552310685e-05 4.761334338390561 0.24421202200330128 S(ph)NFSNSADDIK ddPTM_A459_Selumetinib_30min_R2 2 SNFSNSADDIK 11 0 P45973 P45973 CBX5 Chromobox protein homolog 5 1 S(1)NFSNSADDIK;S(0.998)NFS(0.002)NSADDIK 174.24 0.00014354 42146000.0 138309.0 134007.0 149362.0 148126.0 148243.0 124110.0 138402.0 142119.0 121707.0 150819.0 True False 130622.33947479504 144284.9059995807 139752.2115330498 127950.98326839757 129619.38903076519 141205.02594159308 144837.96723836023 142532.54276093296 146051.8007777084 146464.46359517827 0.891836396819298 0.985118864043214 0.9541714631838555 0.8735974592584369 0.884988657651646 0.9640906911855284 0.9888949420433232 0.9731544380272816 0.9971825055215411 1.0 17.160191143083935 -6.958679143843188 6.543464654724822 0.9861489788007434 0.9212462881808491 0.5330804517183767 0.031797473990974566 0.1816564969033477 20.35725890738104 0.012400790555811267 0.010837809689230265 1.0998180834175352e-07 6.958679143843188 -0.06490269061989429 S(ph)NGDLSPK ddPTM_A459_Selumetinib_30min_R2 1 SNGDLSPK 8 0 P49006 P49006 MARCKSL1 MARCKS-related protein 1 S(1)NGDLSPK 96.756 0.020821 17754000.0 112120.0 77174.0 72369.0 89181.0 88251.0 90891.0 134580.0 146630.0 94136.0 108220.0 True False 105888.81925192139 83092.99764647869 67712.85732940948 77034.39395419427 77164.12040604986 103410.41022365086 140838.23666521074 147056.66902409657 112965.83037960336 105095.40741067198 1.0075494435084977 0.7906434704780541 0.6442989184561982 0.7329948648771475 0.7342292332958231 0.9839669760217323 1.340098869543078 1.3992682710620865 1.0748883625159453 1.0 16.681340100438945 -7.011933962724949 3.679264616606487 1.2341623300954043 0.7742143463826912 0.665465194118956 0.1398644189572783 0.13034057737458188 3.8245557165731925 0.0551105869324853 0.04471052715063471 9.728951475079017e-08 7.011933962724949 -0.45994798371271317 S(ph)NGHASTDQLSEEKEK ddPTM_A459_Selumetinib_30min_R1 1 SNGHASTDQLSEEKEK 16 1 P51159-2;P51159 P51159-2 RAB27A Ras-related protein Rab-27A 1 S(0.867)NGHAS(0.132)T(0.001)DQLSEEKEK 54.805 0.04024 37104000.0 7056.6 6451.4 4934.7 5569.7 4773.6 5400.0 5706.9 6403.5 3590.6 6203.4 True False 7221.005050246625 5696.067088825511 4264.594844366822 4597.056451217716 4341.828722847533 5345.680902807709 5276.423938348448 6233.658378500562 6092.985952951899 6999.666816232973 1.0316212528145403 0.8137626030450084 0.609256834121986 0.6567536101227922 0.6202907705233011 0.7637050509904992 0.7538107279780601 0.8905650143295455 0.8704679969654577 1.0 12.773070536147056 -8.090396867789154 1.2193309456847838 0.9778263553087708 0.7349572510394656 0.3160800243044485 0.1168504849191684 0.5673862986581364 1.5574390397872708 0.11562793013978565 0.03887784899811496 8.120880731558474e-09 8.090396867789154 -0.2428691042693052 S(ph)NMSVAR ddPTM_A459_Selumetinib_30min_R2 2 SNMSVAR 7 0 P53355-4;P53355;P53355-3 P53355-4 DAPK1 Death-associated protein kinase 1 1 S(0.999)NMS(0.001)VAR;S(1)NMSVAR 104.42 0.017999 12996400.0 23202.1 20828.0 29672.0 32345.0 28959.0 23667.0 31261.0 33008.0 28243.0 26395.0 True False 21912.620167365396 22425.440627424483 27762.93582443092 27939.555201762803 25320.91152325525 26926.91442236467 32714.698442496338 33104.047815231424 33892.38917535414 25632.90776755398 0.8548628335916806 0.8748691654799501 1.0830974026120095 1.0899877397884825 0.9878282929456152 1.05048224206731 1.2762773049067206 1.2914667393737662 1.3222217893771293 1.0 14.645709525127124 -5.628904151350641 0.5162646966589327 1.2299744915401216 0.76908015328486 0.5242598429251021 0.10915748742678198 1.6069650894512435 0.6033457276558077 0.0818040885382879 0.4088149357001581 2.3501514412668775e-06 5.628904151350641 -0.4608943382552616 S(ph)NPDFLK ddPTM_A459_Selumetinib_30min_R2 2 SNPDFLK 7 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;J3QL44;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(1)NPDFLK;S(1)NPDFLK 96.171 0.023317 7307400.0 65864.0 49643.0 68965.0 74661.0 79270.0 72495.0 75468.0 85247.0 80597.0 69016.0 True False 62203.54255448231 53450.458472596234 64527.866983414526 64492.043002591236 69311.39391720852 82480.52820591236 78977.41153700509 85495.05465659947 96718.65206833601 67023.32875489698 0.9280879316209355 0.7974903584401712 0.9627672659976602 0.9622327658245294 1.0341383396619848 1.2306241683032793 1.1783570437962572 1.2756014397502284 1.4430595117415648 1.0 16.03237572020887 -6.499990410182127 1.144366622565533 1.2585923323052854 0.878241803492236 0.6397267788989724 0.11090795590341006 0.2784535528196537 0.7687850313294896 0.04959694904139918 0.05785121779533465 3.162347488367695e-07 6.499990410182127 -0.3803505288130494 S(ph)NPEGAEDR ddPTM_A459_Selumetinib_30min_R2 2 SNPEGAEDR 9 0 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9;M0R2I2 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 S(1)NPEGAEDR;S(1)NPEGAEDR 110.8 0.010641 9095900.0 3499.04 1819.63 2497.3 4388.1 4048.7 5447.0 8862.2 14426.9 6119.1 8802.7 True False 3304.577364566925 1959.1897699673725 2336.6264368546554 3790.433210105281 3540.0661101627657 6197.2748070571015 9274.309860116156 14468.87989049814 7343.090981939225 8548.543178838698 0.38656614295955927 0.22918405264855016 0.27333621506864536 0.44340107206666807 0.4141133800348513 0.7249509860812318 1.0848994578484485 1.6925550456731397 0.8589874120442553 1.0 13.061462865158628 -7.046211541079688 1.9686005655961343 1.2310958001754415 0.332279663197861 0.7650687647726515 0.21113945538631082 0.14735844134494855 1.1384315960498412 0.09384888946943758 0.07020746453235523 8.990595507399e-08 7.046211541079688 -0.8988161369775804 down S(ph)NS(ph)TSMHSSIPS(ph)IENK ddPTM_A459_Selumetinib_30min_R1 1 SNSTSMHSSIPSIENK 16 0 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 3 S(0.553)NS(0.553)T(0.496)S(0.223)MHS(0.17)S(0.004)IPS(1)IENK 62.357 0.03161 9380600.0 625.28 605.23 843.19 1019.8 745.77 758.61 709.3 630.66 316.55 627.82 True False 639.8478074169166 534.3693902362062 728.6894293111353 841.7110740168822 678.3152351763874 750.9790721627691 655.7969299392937 613.9328481276119 537.1622301027471 708.4068124846672 0.9032208557858349 0.7543255948682341 1.0286313125015396 1.1881747312178768 0.9575221796601073 1.0600957796111303 0.9257349285492478 0.8666388257536696 0.7582680186525924 1.0 9.468434275792541 -7.5897534313176624 3.89487428623938 0.8605039367069437 0.9828612841581674 0.13821848405289372 0.11816855949830647 0.44170189822853795 13.444770207705298 0.06414494899790488 0.0355677425078722 2.571855527422063e-08 7.5897534313176624 0.12235734745122373 S(ph)NSAPLIHGLSDTSPVFQAEAPSAR ddPTM_A459_Selumetinib_30min_R1 1 SNSAPLIHGLSDTSPVFQAEAPSAR 25 0 Q96E09 Q96E09 FAM122A Protein FAM122A 1 S(0.558)NS(0.442)APLIHGLSDTSPVFQAEAPSAR 66.793 0.001275 109100000.0 921.82 1458.0 1422.9 1885.5 1391.7 1065.0 1399.4 1447.8 611.19 987.37 True False 943.2966124505211 1287.2966821941884 1229.677995430229 1556.232820218505 1265.820980724592 1054.2870669426316 1293.8421313365961 1409.3996408828164 1037.1447904485804 1114.1085572982481 0.8466828535435076 1.1554499548194186 1.1037326545738422 1.3968412772920653 1.1361738247431217 0.946305510388785 1.161325009902274 1.2650469576327996 0.9309189698387134 1.0 10.1216740985298 -8.285636330489432 24.86031584229105 0.9654594347195531 1.1311500878406082 0.16544518231627459 0.14431679752876436 1532.7323596812 1574735.2800122648 0.14076375612340042 0.036427695684182713 5.18040447081283e-09 8.285636330489432 0.16569065312105513 S(ph)NSDESNFSEK ddPTM_A459_Selumetinib_30min_R1 1 SNSDESNFSEK 11 0 O95999;A0A087WWW9 O95999 BCL10 B-cell lymphoma/leukemia 10 1 S(0.986)NS(0.014)DESNFSEK 185.95 1.9068e-05 9253200.0 2538.9 3036.0 2556.6 2751.2 2437.5 2340.3 2596.1 2168.8 1290.9 2350.0 True False 2598.0514301605826 2680.543708601892 2209.4277623985686 2270.7545664201284 2217.028555375578 2316.7587068223856 2400.2740868678993 2111.2763787447534 2190.5630163943656 2651.6453909384363 0.9797884132769026 1.0108982587800808 0.833228971697696 0.8563568017729898 0.8360954156811125 0.8737060825476622 0.9052017645611449 0.7962136965823916 0.8261146169394504 1.0 11.372672138943232 -5.258866402072531 24.990588266504105 0.858868777592939 0.9953433478751542 0.4772700954094675 0.053804886011937086 162.85183860061065 1581710.458145352 0.013112664955784522 0.03153047885680564 5.5097716226164536e-06 5.258866402072531 0.1364745702822152 S(ph)NSDESNFSEK ddPTM_A459_Selumetinib_30min_R2 1 SNSDESNFSEK 11 0 O95999;A0A087WWW9 O95999 BCL10 B-cell lymphoma/leukemia 10 1 S(0.978)NS(0.022)DESNFSEK 156.2 0.00054413 12184000.0 57571.0 46886.0 54010.0 60952.0 49880.0 36811.0 47248.0 55163.0 34702.0 47031.0 True False 54371.434294972976 50482.005437748456 50535.05540164171 52650.232451935284 43613.628467142225 41881.381113012474 49445.125620135885 55323.51519727374 41643.36965489289 45673.092828786896 1.190447831041205 1.105289839402568 1.1064513539969951 1.1527625827596861 0.954908585469241 0.9169814987132955 1.0825876365651232 1.2112933845899825 0.9117703022871676 1.0 15.479056867047053 -6.245057885043301 24.641678346854206 1.0221743355942847 1.134042581333467 0.33929348840765994 0.08532686566823813 971.606726278081 1461527.0239509584 0.026611466362616396 0.03424412494436139 5.687771161982726e-07 6.245057885043301 0.11186824573918219 S(ph)NSDNNLNASAPDWAVCSTATSHR ddPTM_A459_Selumetinib_30min_R1 4 SNSDNNLNASAPDWAVCSTATSHR 24 0 Q9UPX8;Q9UPX8-3;A0A2R8Y2H5;A0A087X158 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 S(0.781)NS(0.219)DNNLNASAPDWAVCSTATSHR;S(0.5)NS(0.5)DNNLNASAPDWAVCSTATSHR;S(0.5)NS(0.5)DNNLNASAPDWAVCSTATSHR;S(0.767)NS(0.233)DNNLNASAPDWAVCSTATSHR 198.02 7.1733e-31 82569000.0 2245.4300000000003 2342.06 2355.37 2183.1499999999996 2555.49 1933.5700000000002 2228.3900000000003 2448.1800000000003 1073.6200000000001 1707.44 True False 2297.744150153797 2067.850526405846 2035.5236911213008 1801.9038353009958 2324.3463807084054 1914.1200413410938 2060.300748212919 2383.2463135906173 1821.8547258976823 1926.6065558740095 1.1926379795336157 1.0733123066052066 1.0565331488752672 0.9352733851170552 1.206445796429858 0.9935189078980108 1.069393614348135 1.2370176496723546 0.9456288417285043 1.0 10.911846264783497 S(ph)NSDNNLNASAPDWAVCSTATSHR ddPTM_A459_Selumetinib_30min_R2 3 SNSDNNLNASAPDWAVCSTATSHR 24 0 Q9UPX8;Q9UPX8-3;A0A2R8Y2H5;A0A087X158 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 S(0.759)NS(0.241)DNNLNASAPDWAVCSTATSHR;S(0.725)NS(0.275)DNNLNASAPDWAVCSTATSHR;S(0.768)NS(0.232)DNNLNASAPDWAVCSTATSHR 248.16 1.4914e-52 115099700.0 7475.900000000001 7478.299999999999 9127.0 9209.6 8309.7 5724.0 6249.1 3187.4 4977.7 11602.6 True False 7060.419406398858 8051.861563475543 8539.77875672624 7955.236592553865 7265.761196339454 6512.429042701453 6539.695532356732 3196.674806297523 5973.379088558591 11267.602790824842 0.6266123804211599 0.7146028940629802 0.7579055558898601 0.7060274257299679 0.6448364688765857 0.5779782233719221 0.5803981249394038 0.2837049606417224 0.5301375278708518 1.0 13.459892990919501 -6.683145421369311 2.023745265495123 0.5426396821533868 0.7058040972477412 0.04317805553800913 0.16942315166175648 0.6164677055958271 5.185799643746154 0.06385903898057141 0.06189834464754881 2.0742188591859624e-07 6.683145421369311 0.16316441509435442 S(ph)NSELEDEILCLEK ddPTM_A459_Selumetinib_30min_R1 2 SNSELEDEILCLEK 14 0 G3V599;Q96PC5-6;Q96PC5-11;Q96PC5-13;Q96PC5-10;Q96PC5-9;Q96PC5-14;Q96PC5-7;Q96PC5-12;Q96PC5;Q96PC5-5;Q96PC5-8;G3V5K6;Q86UF2;A4D2H0;A0A5F9ZHA4;A0A2R8YE69;Q8IX94;P0CG41;A4FU28 G3V599;A0A5F9ZHA4 MIA2;CTAGE5;CTAGE6;CTAGE15;CTAGE4;CTAGE8;CTAGE9 Melanoma inhibitory activity protein 2;cTAGE family member 6;cTAGE family member 15;cTAGE family member 4;cTAGE family member 8;cTAGE family member 9 1 S(1)NSELEDEILCLEK;S(1)NSELEDEILCLEK 233.79 1.0472000000000001e-13 11244600.0 1983.58 2535.3 2505.9 2116.65 2375.69 2203.0 2300.5 2118.92 1265.13 2424.7 True False 2029.793554625204 2238.4658973710066 2165.612543923404 1747.0168119413931 2160.809258962135 2180.839820163959 2126.9714328568234 2062.719358377826 2146.833208560697 2735.9338635780514 0.7419015428869477 0.8181725176805054 0.7915441863390725 0.6385449718644318 0.7897885572921821 0.7971098458176393 0.7774206318259362 0.753936118792069 0.7846802282541548 1.0 11.417817640674933 -11.755648435874352 0.4552401915904899 1.304311249091359 0.761565829829432 0.6931993753031778 0.04689543460848673 46.577509186440885 2.8274232699557778 14.426278081187577 0.0258393483608381 1.7553008539981222e-12 11.755648435874352 -0.5427454192619271 S(ph)NSFNNPLGNR ddPTM_A459_Selumetinib_30min_R1 1 SNSFNNPLGNR 11 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 S(0.694)NS(0.306)FNNPLGNR 114.87 0.0063424 8594000.0 1495.2 1958.9 2187.5 1893.1 1702.9 1874.6 2034.7 2076.9 1216.6 1511.1 True False 1530.0352508472567 1729.551077332096 1890.4495150773967 1562.5056228881745 1548.8729956714133 1855.7432260006153 1881.2209408536316 2021.813865278022 2064.4813430516574 1705.0644043604548 0.8973474825551537 1.0143611425521641 1.1087261632128653 0.9163909696855398 0.9083955959143803 1.0883713373259223 1.103313714158059 1.1857697926879045 1.2107937610872914 1.0 10.735610518982849 -6.938219105032637 4.924964077181611 1.135304628133001 0.9766901472999887 0.4747276594722005 0.07825527824157856 0.18590248987572122 9.040063785522188 0.029346276334744067 0.025539274268796767 1.1528714782142832e-07 6.938219105032637 -0.15861448083301233 S(ph)NSFNNPLGNR ddPTM_A459_Selumetinib_30min_R2 1 SNSFNNPLGNR 11 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 S(0.882)NS(0.118)FNNPLGNR 145.81 0.00069526 15388000.0 37613.0 31477.0 30457.0 35435.0 37416.0 20021.0 30966.0 26784.0 24309.0 27480.0 True False 35522.62003676887 33891.18468549264 28497.429779074297 30608.69187121548 32715.467576715997 22778.71101745734 32405.98035796493 26861.937005670094 29171.479250210094 26686.58099838543 1.3311041994820556 1.2699710272943205 1.0678561551514758 1.1469694028271116 1.2259145365491113 0.8535642321073456 1.2143174264221233 1.0065709431753462 1.0931141479672875 1.0 14.703826863274596 -1.522878745294244 0.4322333604757958 1.0474979217528166 7.1408137825062115 0.43534127769476694 0.10346523251141292 76.34124789192383 0.95517646770884 0.06533097736166521 405.71461284809277 0.029999999999039375 1.522878745294244 6.093315860753394 S(ph)NSGRELTDEEILASVMIK ddPTM_A459_Selumetinib_30min_R1 1 SNSGRELTDEEILASVMIK 19 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 S(0.497)NS(0.497)GRELT(0.005)DEEILASVMIK 96.708 0.00088584 14147000.0 3464.1 3170.7 5074.4 5660.5 5264.6 3534.8 3232.6 3206.9 2263.5 2820.9 True False 3544.806790034767 2799.4729699815607 4385.324351683994 4671.999935744816 4788.417859540624 3499.2431213416103 2988.7623794188107 3121.8425945207237 3840.9941805009225 3182.9899928928635 1.1136719870152862 0.8795104528234023 1.3777373983191155 1.4678022696196618 1.5043772899796852 1.0993572487362173 0.9389795086042577 0.9807893212015517 1.2067251826355982 1.0 11.636166905906567 -6.984791470448476 24.73342395143998 1.0284719686337116 1.2679041888605986 0.2829975578670394 0.18040143208744072 310.714164809163 505308.0622885614 0.07146274524508332 0.06300132763359434 1.0356393168202681e-07 6.984791470448476 0.23943222022688704 S(ph)NSGRELTDEEILASVMIK ddPTM_A459_Selumetinib_30min_R2 1 SNSGRELTDEEILASVMIK 19 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 S(0.571)NS(0.407)GRELT(0.022)DEEILASVMIK 80.975 0.044239 0.0 9580.5 9372.5 9726.1 9242.8 8697.5 6567.5 5114.4 5296.1 5084.7 8694.7 True False 9048.054163780185 10091.34061266257 9100.333314977 7983.914695280667 7604.84229336346 7472.113511170827 5352.229733991342 5311.510774183444 6101.782078388388 8443.661419456394 1.071579462308983 1.1951379989502533 1.07777098854384 0.945551260130309 0.900656944372488 0.884937604669123 0.6338754561686251 0.6290530269184338 0.7226464652322858 1.0 13.043653014192186 -6.2866924657862135 1.0069057619167026 0.7266678060748275 1.1397495791376717 0.6415180039047863 0.10971128246333182 0.31015209476504707 0.6645877529800135 0.05052832293911418 0.07632875597459247 5.167821854465487e-07 6.2866924657862135 0.4130817730628442 S(ph)NSLPHSAVSNAGSK ddPTM_A459_Selumetinib_30min_R1 1 SNSLPHSAVSNAGSK 15 0 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 S(0.5)NS(0.5)LPHS(0.001)AVSNAGSK 88.471 0.011637 14136000.0 9528.7 9962.8 10542.0 10922.0 11486.0 9876.1 11183.0 8657.5 3421.7 6749.1 True False 9750.700170377388 8796.350744419931 9110.454303060982 9014.67773133201 10447.093328018009 9776.755400781334 10339.457306515047 8427.874976476716 5806.374988919823 7615.412726801104 1.2803902454375868 1.1550720965474035 1.1963178661346012 1.1837411910199482 1.3718354740316705 1.2838116266993336 1.3577015031801425 1.1066865682560176 0.7624504668650866 1.0 12.894706512152544 -8.036187330737814 4.929439464670622 0.8889945480992918 1.2561882253196621 0.7575752905549663 0.08545325762860764 0.09657675174950107 5.742790235604874 0.0591602770547754 0.022663372274591715 9.200526260818701e-09 8.036187330737814 0.36719367722037033 S(ph)NSLPHSAVSNAGSK ddPTM_A459_Selumetinib_30min_R2 2 SNSLPHSAVSNAGSK 15 0 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 S(0.499)NS(0.499)LPHS(0.002)AVSNAGSK;S(0.745)NS(0.253)LPHS(0.002)AVSNAGSK 78.418 0.021841 95037000.0 120247.0 101975.0 131840.0 161144.0 152088.0 105229.0 116110.0 117098.0 95980.0 127144.0 True False 113564.15312688013 109796.15459869486 123357.55793653877 139195.90921109478 132981.34575602898 119723.33957624603 121509.3450676001 117438.73579338241 115178.68190526804 123473.02236021537 0.9197487107391971 0.8892319350406751 0.9990648611213245 1.1273386408652901 1.0770072945009348 0.9696315623259778 0.9840963049654157 0.9511287044612161 0.9328246746017947 1.0 16.913836336014406 -5.291417725141088 7.538681705899554 1.0084620761853678 0.9044551670430518 0.34550426823740643 0.05527624699049936 0.25117660003318804 54.62128128540009 0.01650806172920895 0.03553659744853274 5.111899121680465e-06 5.291417725141088 -0.10400690914231592 S(ph)NSLSTPRPTR ddPTM_A459_Selumetinib_30min_R2 1 SNSLSTPRPTR 11 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(0.635)NS(0.365)LSTPRPTR 102.52 0.0078093 9245900.0 26718.0 15297.0 23532.0 25470.0 16085.0 13883.0 18757.0 37475.0 15788.0 29611.0 True False 25233.120520628258 16470.23071239256 22017.97673970438 22000.942061799287 14064.258498275514 15795.25723267371 19629.237666290395 37584.04604567979 18946.041153577575 28756.053491382492 0.8774889964713004 0.5727569924478092 0.7656814502136966 0.7650890644083844 0.48908861928811753 0.5492845962818638 0.6826123644599845 1.3069959706724998 0.6588540099654236 1.0 14.811578072048093 -7.569703291197208 24.924041987429543 0.9887168732175341 0.6617783021388095 0.390594381316707 0.18128426209028212 113.8216940195411 60584.38895166759 0.08097056285238732 0.046748381042848605 2.6933742814384796e-08 7.569703291197208 -0.3269385710787246 S(ph)NSMLELAPK ddPTM_A459_Selumetinib_30min_R2 1 SNSMLELAPK 10 0 A6PVU7;Q9P2M7-2;Q9P2M7;A2A3M4 A6PVU7 CGN Cingulin 1 S(0.724)NS(0.276)MLELAPK 104.17 0.013434 5733600.0 55627.0 35788.0 44844.0 56155.0 46556.0 36593.0 36369.0 40930.0 33212.0 46054.0 True False 52535.474032524435 38532.82452344285 41958.7858624555 48506.59212722183 40707.21906407926 41633.35359181944 38060.23056380634 41049.09952367374 39855.32802081444 44724.30135733777 1.1746516421302378 0.8615634756499309 0.9381652611454704 1.0845690297018695 0.9101812175630679 0.9308888530013626 0.8509966485493669 0.9178253942012434 0.891133607708676 1.0 15.448771325523076 -6.358604693524101 20.189352579754644 0.9101353143819495 0.9983267971970232 0.22811942202327606 0.08560125355543916 15.46861912831845 3207.483558684239 0.02592763747482131 0.0293991555090694 4.379205308046754e-07 6.358604693524101 0.08819148281507372 S(ph)NSPGTASSGSSR ddPTM_A459_Selumetinib_30min_R2 1 SNSPGTASSGSSR 13 0 H0YAP0;Q96GY0 H0YAP0 ZC2HC1A Zinc finger C2HC domain-containing protein 1A 1 S(0.653)NS(0.314)PGT(0.031)AS(0.002)SGSSR 120.32 0.0030585 4822800.0 17976.0 15837.0 15808.0 16792.0 20322.0 18503.0 25762.0 59516.0 20042.0 39790.0 True False 16976.965883629524 17051.64697601889 14790.930490449035 14504.90063218429 17768.96867901492 21051.620296489364 26959.984046434558 59689.181706595824 24050.960020268656 38641.15931316432 0.43934928934302936 0.44128197184316137 0.3827765717528574 0.3753743647966261 0.45984564114672843 0.5447978443368667 0.6977012213308466 1.5447047336972843 0.6224181791583812 1.0 15.237850758150232 -7.530280019375155 24.912654402157568 1.0743776366845046 0.4513355793925893 0.6270500277200006 0.2122568651934773 103.51403469242265 348421.56434194697 0.09359243531202208 0.05417708095294827 2.949306993416082e-08 7.530280019375155 -0.6230420572919153 S(ph)NSRLEDQVIGVALQASK ddPTM_A459_Selumetinib_30min_R1 1 SNSRLEDQVIGVALQASK 18 1 A0A3B3IRW6;Q2KHR3-2;Q2KHR3 A0A3B3IRW6 QSER1 Glutamine and serine-rich protein 1 1 S(0.721)NS(0.279)RLEDQVIGVALQASK 64.589 0.019258 10622000.0 1142.9 1324.9 1811.2 2230.2 1455.3 1484.8 1336.2 1184.4 739.64 918.26 True False 1169.5273463037256 1169.7800920707 1565.248988209454 1840.7374360388799 1323.6683719540838 1469.8642600905337 1235.4093582192083 1152.9858645265977 1255.1150588317673 1036.1276156098413 1.1287483594531627 1.128992292500759 1.5106720105015092 1.776554748958663 1.277514808033567 1.4186131495254133 1.1923332025969353 1.1127836447520765 1.2113518064017963 1.0 10.01698598949054 -7.395036080542117 3.471595424193036 1.1242163454343554 1.3828742932232467 0.3031717894744458 0.18350644621683687 0.36454769562812833 8.052311888660265 0.09284896462447913 0.0589261838557446 4.026835785806485e-08 7.395036080542117 0.2586579477888913 S(ph)NSSEALLVDR ddPTM_A459_Selumetinib_30min_R1 1 SNSSEALLVDR 11 0 Q96HB5-2;Q96HB5;Q96HB5-5;Q96HB5-3;Q96HB5-4 Q96HB5-2 CCDC120 Coiled-coil domain-containing protein 120 1 S(1)NSSEALLVDR 125.36 0.0034261 0.0 2827.8 2286.9 3770.0 4081.0 2727.6 2480.0 2293.1 2394.8 1548.4 2286.5 True False 2893.6822380590384 2019.1486848490335 3258.054707127673 3368.3299598577137 2480.8890615968917 2455.0534516598377 2120.129620814598 2331.282124593293 2627.521709338474 2579.994547396057 1.1215846331844308 0.7826174233146829 1.262814570835419 1.305557007187209 0.9615869398254385 0.9515731163609163 0.8217574036946735 0.9035996323892291 1.0184214195298922 1.0 11.333152301297833 -6.495551754687034 23.96333528433607 0.9291428271761748 1.1081435885411461 0.27348273444743165 0.1395427262160726 627.2494886163894 550042.0922510934 0.046017688295774586 0.052017686751106205 3.1948336151709087e-07 6.495551754687034 0.17900076136497134 S(ph)NSSEALLVDR ddPTM_A459_Selumetinib_30min_R2 1 SNSSEALLVDR 11 0 Q96HB5-2;Q96HB5;Q96HB5-5;Q96HB5-3;Q96HB5-4 Q96HB5-2 CCDC120 Coiled-coil domain-containing protein 120 1 S(0.494)NS(0.488)S(0.018)EALLVDR 139.64 0.0011523 3369100.0 11713.0 9782.5 12075.0 16969.0 13976.0 13050.0 9963.6 11096.0 8350.5 9379.1 True False 11062.038350854053 10532.78629430478 11298.107646265942 14657.792926842261 12220.209932974738 14847.519043894823 10426.927142498846 11128.287522958313 10020.8333324645 9108.301013171644 1.2145007433172312 1.1563941814256213 1.2404187817165448 1.6092784928435522 1.3416563544949731 1.6301085155643862 1.144771909428588 1.2217742372441949 1.1001868864427329 1.0 13.152966255433281 -7.966560970735693 1.4707988868319533 1.0362783702928933 1.3535570014763547 0.36434402680862943 0.15671398825147148 0.4998525937742704 1.9435694485122934 0.14746133114371357 0.05026448180030803 1.0800379833737391e-08 7.966560970735693 0.31727863118346145 S(ph)NSTTQVSQPR ddPTM_A459_Selumetinib_30min_R2 1 SNSTTQVSQPR 11 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.754)NS(0.242)T(0.004)TQVSQPR 91.202 0.02675 81403000.0 14586.0 13804.0 16999.0 18601.0 23090.0 10279.0 13737.0 17037.0 11359.0 14412.0 True False 13775.368512384288 14862.72241314421 15905.302847111785 16067.511711485224 20189.227772780952 11694.83894652835 14375.79771934911 17086.57484937282 13631.117396977936 13995.88811312703 0.9842439723038431 1.0619349263877123 1.136426836121523 1.1480165875586827 1.4425113725970031 0.8355910573162929 1.0271443729151961 1.2208281969149906 0.9739372940680364 1.0 13.772715415995924 -6.805182811972532 24.999992325169178 1.0262801718416361 1.1481023629382758 0.20072298040447745 0.1409717934673575 283.8855754785934 162242.69482116203 0.05171076686293629 0.04560483557125 1.5660917005076388e-07 6.805182811972532 0.12182219109663972 S(ph)NTPILVDGK ddPTM_A459_Selumetinib_30min_R1 1 SNTPILVDGK 10 0 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41 P06744-2 GPI Glucose-6-phosphate isomerase 1 S(0.5)NT(0.5)PILVDGK 149.32 0.00075264 43795000.0 11738.0 14958.0 8700.7 9500.6 8393.2 9025.6 11694.0 10167.0 6102.7 11290.0 True False 12011.472561827926 13206.71040621446 7519.192729524066 7841.498558349473 7634.0365419398195 8934.810658589126 10811.912165106593 9897.33813292968 10355.836176427218 12739.181473912731 0.9428763210905657 1.036700076316452 0.5902414330875067 0.6155417892748665 0.5992564402644537 0.7013645795756824 0.8487132542422136 0.7769210410572632 0.8129122108538823 1.0 13.636984963151232 -9.52332887268455 14.497612885615357 0.9999999999989355 0.7630094132676282 0.1922942019023971 0.1412438498881471 0.0 0.0 0.1511078431732008 0.03664903519190445 2.996892240854364e-10 9.52332887268455 -0.23699058673130735 S(ph)NVCINGNHVYLEQPEAK ddPTM_A459_Selumetinib_30min_R1 1 SNVCINGNHVYLEQPEAK 18 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 S(1)NVCINGNHVYLEQPEAK 71.042 0.014888 4561900.0 2608.3 2345.9 2717.5 2126.4 2986.8 2488.3 2543.5 2793.7 1690.7 2575.7 True False 2669.068315131689 2071.2409374206777 2348.4784261590057 1755.0641574715614 2716.6444673623696 2463.2699611956346 2351.641747216402 2719.6020007834813 2868.9944161576823 2906.316184442608 0.9183681835510887 0.7126688240281446 0.8080601961790376 0.6038792912025017 0.9347380996962603 0.8475574592955226 0.809148625949456 0.9357557224301333 0.9871583936790127 1.0 11.50497595009439 -7.749806282037343 0.8056626357869003 1.0120386498466394 0.778480309558269 0.43116755436580645 0.09020976767322272 0.5839247211506412 0.7095386217031429 0.08119209699011351 0.036724597837053494 1.7790727922235513e-08 7.749806282037343 -0.23355834028837041 S(ph)NVCINGNHVYLEQPEAK ddPTM_A459_Selumetinib_30min_R2 1 SNVCINGNHVYLEQPEAK 18 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 S(1)NVCINGNHVYLEQPEAK 82.21600000000002 0.0064697 14446000.0 90668.0 63787.0 67061.0 69918.0 56748.0 69819.0 86247.0 79094.0 50531.0 52874.0 True False 85629.03553276157 68679.2577924681 62746.368270496074 60395.047784722585 49618.80890644319 79435.93349622171 90257.65639518833 79324.15044528346 60638.61195410619 51347.39023684971 1.6676414348963244 1.3375413526504818 1.2219972228591636 1.176204817930158 0.9663355562486603 1.5470296178599963 1.7577846893261282 1.5448526220979406 1.180948275548162 1.0 15.648003332080558 S(ph)NY(ph)KMMFVK ddPTM_A459_Selumetinib_30min_R1 1 SNYKMMFVK 9 1 O00193 O00193 SMAP Small acidic protein 2 S(1)NY(1)KMMFVK 64.265 0.031873 4234100.0 764.78 1020.0 1354.7 1205.1 1037.3 919.45 995.11 829.75 406.97 623.95 True False 782.5978859971683 900.5779258148652 1170.7391808344444 994.6519075286762 943.4763981501889 910.2011677938054 920.0480515323425 807.7423345921519 690.5983660872374 704.0400602876755 1.111581471198377 1.2791572193305067 1.6628871663298144 1.412777430764742 1.3400890820966609 1.2928258193459774 1.3068120742396458 1.1472959852058744 0.9809077707951083 1.0 9.459513711157264 -7.898343142650189 1.439692100219572 0.9749718805948755 1.3672895062093295 0.5492607537522383 0.13009723413451485 0.3407748126719346 1.279472781221769 0.12064110521760539 0.042775336448410396 1.2637374547929582e-08 7.898343142650189 0.39231762561445405 S(ph)PAAGSSQSSGWPNDVDAGPASLKK ddPTM_A459_Selumetinib_30min_R2 1 SPAAGSSQSSGWPNDVDAGPASLKK 25 1 K7EN08;Q14938-6;Q14938-5;Q14938-3;Q14938-4;Q14938 K7EN08 NFIX Nuclear factor 1;Nuclear factor 1 X-type 1 S(0.781)PAAGS(0.07)S(0.07)QS(0.07)S(0.009)GWPNDVDAGPASLKK 94.802 0.00065678 0.0 13089.0 11838.0 13534.0 14162.0 13354.0 10604.0 9435.5 12085.0 7914.8 11041.0 True False 12361.565779418479 12745.936534830567 12663.23717470504 12233.111169187341 11676.351133725288 12064.604746472094 9874.269446088552 12120.165349220553 9497.981157989343 10722.217642036883 1.1528926377090563 1.1887407027497383 1.1810278057645753 1.1409124098756342 1.0889865812784554 1.1251967782459786 0.9209167147825916 1.1303785983323973 0.8858224553055264 1.0 13.388315704215225 -6.8643969582947495 0.8421677296609652 0.9807003695864562 1.17918652632092 0.5872356764062783 0.06586672865652815 0.4219439955158157 0.6415624426579403 0.041783550763022106 0.035447310907580264 1.3664792512340612e-07 6.8643969582947495 0.1984861567344638 S(ph)PAAPGQSPTGSVCYER ddPTM_A459_Selumetinib_30min_R1 1 SPAAPGQSPTGSVCYER 17 0 O75534;O75534-4 O75534 CSDE1 Cold shock domain-containing protein E1 1 S(0.995)PAAPGQS(0.001)PT(0.004)GSVCYER 139.46 0.00050636 7754900.0 372.3 554.72 704.91 505.65 467.0 428.57 370.63 387.15 164.35 391.61 True False 380.9738656303065 489.7731245176682 609.1870937934658 417.3477197260605 424.7599324555464 424.258974910426 342.67308070407495 376.88152435956795 278.8899463509289 441.87695810442557 0.8621718300601537 1.1083925412601479 1.3786351214301178 0.9444885325462745 0.9612629141779463 0.9601292104716715 0.775494341624153 0.8529105612936312 0.6311484254515504 1.0 8.787500892774634 -6.6943877402391925 1.2466547889538804 0.8032280907287455 1.1006342208913729 0.3536830270160787 0.1526997259520414 0.47087697267617 1.5420991962478707 0.07435160866347192 0.07136869470511623 2.0212138232884233e-07 6.6943877402391925 0.2974061301626274 S(ph)PAAPGQSPTGSVCYER ddPTM_A459_Selumetinib_30min_R2 1 SPAAPGQSPTGSVCYER 17 0 O75534;O75534-4 O75534 CSDE1 Cold shock domain-containing protein E1 1 S(1)PAAPGQSPTGSVCYER 202.35 3.6245e-08 9043000.0 4089.0 2019.4 1793.2 1864.3 4411.7 4333.9 4927.9 4560.7 4653.1 3046.0 True False 3861.7497495639254 2174.281486605579 1677.8274642885376 1610.379123903118 3857.4628049015914 4930.855385772856 5157.057114448599 4573.970881935473 5583.850018476802 2958.0540655415566 1.305503437056659 0.7350377776842678 0.5672064901833913 0.5444048987009613 1.304054192192519 1.6669253761155043 1.7433951510634247 1.5462769714785711 1.8876767952023614 1.0 11.530432706056425 -6.467251954846459 3.990751591687903 1.6075305332168566 0.7724071141247001 0.6104245906062826 0.29311970608156757 0.14364905737235498 4.638558600878403 0.0944320857392786 0.10433848774464909 3.409950268229865e-07 6.467251954846459 -0.8351234190921565 S(ph)PAASQPPVSR ddPTM_A459_Selumetinib_30min_R2 1 SPAASQPPVSR 11 0 Q07343-3;Q07343;E9PMG3;H0YCV7 Q07343-3 PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 S(1)PAASQPPVSR 96.665 0.020006 5099100.0 4320.6 2048.1 3942.6 4864.6 4843.1 1790.1 2149.1 1561.4 3553.7 4508.1 True False 4080.478348732183 2205.1826843205345 3688.937408378311 4202.033088096935 4234.666480136657 2036.670026090126 2249.0374083608613 1565.9434154963155 4264.539298674222 4377.9394395495365 0.9320545441697657 0.5037033323027041 0.8426195609407243 0.9598198298808124 0.9672738827498213 0.46521201451331334 0.5137205389465765 0.35768960195060207 0.97409737104838 1.0 12.096036282381984 -6.759949768063925 24.998821884386466 0.6127230529685695 0.8290308886343931 0.11239760341794691 0.2302241187327151 73.67991833262887 1236512.258312857 0.0777414960040053 0.07380787859651658 1.738001840165079e-07 6.759949768063925 0.21630783566582357 S(ph)PACSSLTPSLCK ddPTM_A459_Selumetinib_30min_R1 2 SPACSSLTPSLCK 13 0 Q96R06;J3KSV2;J3QRV8;F5GZT2 Q96R06 SPAG5 Sperm-associated antigen 5 1 S(1)PACSSLTPSLCK;S(1)PACSSLTPSLCK 87.184 0.025472 17858500.0 3131.48 3018.3999999999996 3993.1 3907.0 3467.1 3596.2 3134.2 2958.1 2018.05 2700.16 True False 3204.4373912006217 2665.0043247839103 3450.858952528251 3224.715793473189 3153.501417166222 3560.025493088346 2897.7847706411044 2879.641578737022 3424.4834574596375 3046.7518377856686 1.0517552993517045 0.8747034437569401 1.1326353888527663 1.0584110440110088 1.0350371756756327 1.1684658556489842 0.9511062682240536 0.9451513388861694 1.123978466178098 1.0 11.573056279935495 -5.26383577509625 24.9962121038801 1.0500902938550238 0.9632293774957246 0.16053938772488618 0.08097808792005817 364.5034497992441 3802093.045997618 0.020880031186372893 0.04704798029193779 5.447085909984486e-06 5.26383577509625 -0.08686091635929927 S(ph)PACSSLTPSLCK ddPTM_A459_Selumetinib_30min_R2 1 SPACSSLTPSLCK 13 0 Q96R06;J3KSV2;J3QRV8;F5GZT2 Q96R06 SPAG5 Sperm-associated antigen 5 1 S(1)PACSSLTPSLCK 115.12 0.0040667 11243000.0 53316.0 57137.0 65638.0 71216.0 66555.0 60132.0 61407.0 62724.0 56112.0 66660.0 True False 50352.91016085841 61519.22417558829 61414.92254125083 61516.257945547644 58193.76589075086 68414.63717605245 64262.5471756621 62906.516455482844 67335.96790027514 64735.35259652013 0.7778270781144265 0.9503188243836842 0.948707623854855 0.9502730035157709 0.8989487746125149 1.0568357849607217 0.9926963335813598 0.9717490356090901 1.0401730306462376 1.0 15.982266176566744 -3.6597487723236 0.732132509316599 0.9926428562891605 8.267673200271179e-51 0.6660022937225045 0.04318092728136653 8.079640055909772 0.9454248524399582 0.01699484918664027 9.646131465403137 0.000218902755132113 3.6597487723236 -0.9926428562891605 S(ph)PAFALK ddPTM_A459_Selumetinib_30min_R2 1 SPAFALK 7 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 S(1)PAFALK 80.165 0.0454 15518000.0 64231.0 58582.0 71091.0 79841.0 76710.0 62698.0 65514.0 70472.0 57490.0 66428.0 True False 60661.298157065394 63075.051029180955 66517.08245802831 68966.51806659292 67073.00400389894 71334.08038422353 68560.53081352831 70677.06185273232 68989.60640481206 64510.051039328515 0.9403387097009622 0.9777554042040253 1.0311119180091208 1.0690817470373342 1.0397295138242555 1.105782420490332 1.062788351721043 1.0955976737585293 1.0694396499973715 1.0 15.977236337835711 -5.172004803482169 1.2989386498672375 1.0697730192843407 0.9233423600585177 0.6896664725934225 0.0279255629171334 0.3770718641922547 0.8854916500769996 0.00812233061428879 0.06093687450306977 6.729692129166806e-06 5.172004803482169 -0.146430659225823 S(ph)PAFTSR ddPTM_A459_Selumetinib_30min_R2 2 SPAFTSR 7 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 S(1)PAFTSR;S(1)PAFTSR 85.86200000000002 0.035661 34579000.0 18371.6 16455.5 17310.3 19099.3 23528.0 16686.5 17989.6 16702.1 19082.4 16962.1 True False 17350.580019341778 17717.583937227944 16196.5741440296 16497.94239186979 20572.202297011278 18984.913910034556 18826.152045716135 16750.700345818488 22899.413206804456 16472.360100171518 1.0533147596233714 1.0755947435269742 0.9832576537627389 1.0015530434948423 1.2488922153175288 1.1525315009254125 1.14289342457491 1.0168974114185418 1.390171964888384 1.0 14.00775965355 -6.242394092501632 24.433869712999073 1.1583240996175463 1.0285723455929916 0.2646989874883301 0.1062555755775669 847.8822984242947 1087777.0921818104 0.029975709563259244 0.038630616710177174 5.722764935710206e-07 6.242394092501632 -0.12975175402455474 S(ph)PAGGESATVAAK ddPTM_A459_Selumetinib_30min_R1 3 SPAGGESATVAAK 13 0 Q147X3 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 S(1)PAGGESATVAAK;S(1)PAGGESATVAAK;S(1)PAGGESATVAAK 198.48 0.00012571 79908000.0 7709.599999999999 9037.8 5932.139999999999 5724.82 7231.4 7025.900000000001 8782.6 9580.3 5244.790000000001 8787.2 True False 7889.2186797298145 7979.650174440772 5126.587970912561 4725.0876551807505 6577.321146807367 6955.22582500679 8120.121411088177 9326.199322799863 8900.025565694476 9915.12271457626 0.7956753443032877 0.8047959066315798 0.5170473546813439 0.4765536233086032 0.6633625559810794 0.7014765248222178 0.8189632791080593 0.9406035196205268 0.8976213226902894 1.0 13.275414912750607 -7.416188367264857 1.685424020639247 0.9486910858764721 0.6438575123943483 0.6307431044043598 0.09948260104951276 0.2810222642743321 1.5519456471903876 0.06794551658688672 0.03645016860967218 3.835408556001366e-08 7.416188367264857 -0.3048335734821238 S(ph)PAGGESATVAAK ddPTM_A459_Selumetinib_30min_R2 4 SPAGGESATVAAK 13 0 Q147X3 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 S(1)PAGGESATVAAK;S(1)PAGGESATVAAK;S(1)PAGGESATVAAK;S(1)PAGGESATVAAK 228.17 5.8349e-13 165941000.0 111587.0 64799.0 97602.0 101286.0 117619.0 90232.0 132829.0 121554.0 132740.0 76911.0 True False 105385.44125815333 69768.87493837526 91322.39358102264 87490.67207190441 102842.64969279879 102660.63895545728 139005.8116956702 121907.702015652 159291.70906548566 74690.37959122339 1.4109640603638973 0.9341079175151703 1.2226794679693076 1.1713780616825937 1.37691962814557 1.374482758252317 1.8610939247657046 1.632174085643246 2.1326937945325892 1.0 16.188634809848438 -6.873202714548885 1.7303235898841092 1.7065335134377162 1.1781574734313507 0.3152904365512763 0.29419683624075504 0.36274800298071413 2.2321602279631114 0.12256915009057712 0.10265937838831364 1.3390515158061334e-07 6.873202714548885 -0.5283760400063655 S(ph)PAGPAATPAQAQAASTPR ddPTM_A459_Selumetinib_30min_R1 1 SPAGPAATPAQAQAASTPR 19 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 S(1)PAGPAATPAQAQAASTPR 124.84 0.00040107 3914900.0 252.76 420.47 210.92 206.24 328.45 306.77 363.36 544.76 164.56 282.57 True False 258.6488162146557 371.24117692880026 182.2782225006283 170.22405560427708 298.74175549255744 303.6841723248741 335.95146265718574 530.3111951701364 279.24630101313534 318.8406119648824 0.8112166596993726 1.1643472098519538 0.571690730918258 0.5338844840224615 0.936962683804726 0.9524638986652126 1.0536658444696123 1.6632485802296282 0.8758178554866529 1.0 8.316691592467969 -7.096785868495861 1.970751998067889 1.2108930874536217 0.7947575185162514 0.2876702884492678 0.2544231049359129 0.4019217108577327 3.086279198746403 0.12061035459171562 0.0869196716285368 8.00228715330486e-08 7.096785868495861 -0.41613556893737025 S(ph)PAGPAATPAQAQAASTPR ddPTM_A459_Selumetinib_30min_R2 2 SPAGPAATPAQAQAASTPR 19 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 S(1)PAGPAATPAQAQAASTPR;S(1)PAGPAATPAQAQAASTPR 238.72 1.0308e-29 19208900.0 5227.5 3161.7 2894.8999999999996 4672.7 5409.8 4811.5 3470.6000000000004 8040.9 5867.9 4340.3 True False 4936.976477340529 3404.1922235321663 2708.645285728803 4036.2701991428953 4730.172559774382 5474.240450551724 3631.9897768634323 8064.297687757348 7041.643962824789 4214.984261546296 1.1712917939886602 0.8076405538661051 0.642622870609514 0.9576003013738803 1.1222278106535766 1.2987570322607709 0.8616852523029379 1.9132450294841445 1.6706216502553473 1.0 12.041311528918056 -7.089904160761205 1.046074552118012 1.5140767407618514 0.8847014584380705 0.33150726584400847 0.30525955483821254 0.5454125654238597 1.2065097925151422 0.2024701963546104 0.13370435132049283 8.130099097722204e-08 7.089904160761205 -0.6293752823237809 S(ph)PAGSPELR ddPTM_A459_Selumetinib_30min_R1 1 SPAGSPELR 9 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 S(1)PAGSPELR 114.51 0.0057321 0.0 919.97 1089.0 1084.6 1374.0 1155.9 912.93 1010.1 999.81 647.19 786.89 True False 941.4035110499948 961.499373737635 937.3172772813457 1134.0566931743438 1051.3490490907195 903.7467530741187 933.9073437638245 973.2917909594197 1098.234161112611 887.8949964576789 1.0602644623584905 1.082897614665705 1.0556623035616155 1.2772419010116565 1.1840916474190668 1.0178531883608777 1.0518218342143106 1.0961789342686212 1.236896441013966 1.0 9.794245261567434 -10.64698242172471 4.176725679997903 0.999975456101775 1.11630801189699 0.15703814081476242 0.08199264745637064 61688251.03109661 0.7805094938791902 15152.416074080165 0.02093975384280423 2.2543304554010462e-11 10.64698242172471 0.11633255579521495 S(ph)PAGSQQQFGYSPGQQQTHPQGSPR ddPTM_A459_Selumetinib_30min_R2 1 SPAGSQQQFGYSPGQQQTHPQGSPR 25 0 Q8TAP9 Q8TAP9 MPLKIP M-phase-specific PLK1-interacting protein 1 S(0.974)PAGS(0.026)QQQFGYSPGQQQTHPQGSPR 154.25 6.8367e-11 5803900.0 6617.5 7411.5 7990.9 10191.0 7502.9 6426.8 6275.4 6452.7 4624.7 7367.1 True False 6249.725841951398 7979.938218271393 7476.774193834082 8802.968219544426 6560.318625222964 7312.033363318263 6567.218534469198 6471.47628869801 5549.769224914504 7154.392680975446 0.873550854787481 1.1153900231799116 1.045060639977995 1.2304284391535816 0.9169637337167403 1.022034110982195 0.91792816348093 0.9045458611611565 0.7757149310062522 1.0 12.804613589932389 -7.098519919690072 1.35647385557218 0.8814018506315129 1.0579249189731477 0.28636471231321603 0.10484264288834073 0.5093046536249587 1.8757655859980755 0.05789540736519003 0.03883105818948294 7.970399320955469e-08 7.098519919690072 0.17652306834163478 S(ph)PAKSPNPSTPR ddPTM_A459_Selumetinib_30min_R1 1 SPAKSPNPSTPR 12 1 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 S(1)PAKSPNPSTPR 118.52 0.021372 5908400.0 1071.6 1051.2 1903.4 1820.1 2008.2 1510.5 1437.8 1605.3 957.52 947.82 True False 1096.5661950293752 928.1250153103788 1644.9287346278006 1502.2537025084596 1826.558664576506 1495.3057414242664 1329.345588420579 1562.7222292507145 1624.841505506183 1069.4819295486245 1.0253246592882421 0.8678267389726674 1.5380612698356144 1.4046555261971436 1.7078910957826152 1.3981589591283334 1.2429808785844843 1.46119554344435 1.5192790645765735 1.0 10.062696390941733 -5.259306865544517 24.99824310122505 1.429698183763072 0.946575663508014 0.5052813569286472 0.18212063602779635 132.9327219063967 1558268.1765431596 0.045171727290744014 0.10805262793253873 5.504186419504446e-06 5.259306865544517 -0.483122520255058 S(ph)PALSDANK ddPTM_A459_Selumetinib_30min_R1 1 SPALSDANK 9 0 P52701-2;P52701;P52701-3;A0A087WWJ1;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 S(1)PALSDANK 123.01 0.0057637 99940000.0 4947.7 6467.8 4464.7 4200.2 5559.9 5214.6 5563.1 6453.9 3078.4 6024.3 True False 5062.971783451697 5710.546969201358 3858.41826284162 3466.713917518833 5057.00802668007 5162.145858477978 5143.470888122497 6282.721606778293 5223.819962559775 6797.577586651239 0.7448200066732775 0.8400855887861375 0.5676166566187636 0.509992548570038 0.7439426710790007 0.7594096268375305 0.7566623289777525 0.9242589035123342 0.7684825801500326 1.0 12.730804997736422 -7.9160762527892485 0.6926336644648564 0.9667742643167831 0.6745423788746503 0.4638075437580087 0.10121459532921724 0.6524730733004415 0.637785394893115 0.10317161076939053 0.0485296638904728 1.213175824129202e-08 7.9160762527892485 -0.29223188544213285 S(ph)PALSDANK ddPTM_A459_Selumetinib_30min_R2 4 SPALSDANK 9 0 P52701-2;P52701;P52701-3;A0A087WWJ1;F8WAX8;F8W7G9 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 S(1)PALSDANK;S(1)PALSDANK;S(1)PALSDANK;S(1)PALSDANK 163.84 0.00096456 245706000.0 673188.0 492124.0 604969.0 637559.0 700638.0 582451.0 640485.0 678328.0 566017.0 648319.0 True False 635774.9059450818 529868.3283719334 566045.9531804449 550722.3643493799 612617.5906568075 662678.3382862522 670268.8215969509 680301.822176754 679236.2158363637 629600.3459349438 1.0098071102565374 0.8415947224188539 0.8990559754853344 0.8747173788978282 0.9730261341376534 1.052538078425272 1.0645941126376213 1.0805296194151857 1.0788371070980143 1.0 19.264076807973588 -6.5902283814753915 2.736511752278163 1.0622166803530746 0.9015163237829452 0.7020047220247754 0.045628124445426396 0.13765927704879255 2.0927467037195706 0.01557258088384565 0.01595113694167566 2.5690444497853037e-07 6.5902283814753915 -0.16070035657012938 S(ph)PAPGLASGDRPPSVSSVHSEGDCNR ddPTM_A459_Selumetinib_30min_R2 2 SPAPGLASGDRPPSVSSVHSEGDCNR 26 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 S(0.941)PAPGLAS(0.058)GDRPPS(0.001)VSSVHSEGDCNR;S(0.995)PAPGLAS(0.005)GDRPPSVSSVHSEGDCNR 68.569 0.00048054 33628000.0 22609.9 28636.0 46477.0 58349.0 67923.0 37632.0 34023.0 35682.0 47335.0 44373.0 True False 21353.332272600957 30832.289120747442 43486.72042033144 50401.76554236071 59389.90550067567 42815.46641071647 35605.136915295516 35785.82871252689 56803.32265040498 43091.83619510029 0.4955308048587847 0.7155018639993158 1.0091637827509436 1.1696360608576617 1.3782170996795104 0.9935864932018088 0.826261771582246 0.8304549509216755 1.3181922068306697 1.0 15.395126954282834 -5.104437914946514 2.3381805994933753 1.067487272320287 0.4977067170277356 0.5516865446787986 0.17209361584734376 0.28558710660576325 2.7507392718902164 0.050815256717112935 0.2474434583692964 7.862525827319143e-06 5.104437914946514 -0.5697805552925514 S(ph)PAPPADK ddPTM_A459_Selumetinib_30min_R2 1 SPAPPADK 8 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 S(1)PAPPADK 85.53299999999999 0.03514 4694200.0 22578.0 13974.0 15867.0 18227.0 19993.0 18266.0 30803.0 40415.0 27552.0 27954.0 True False 21323.205146895154 15045.760866508057 14846.134494683374 15744.451156671206 17481.30060031224 20781.975697761158 32235.40053498655 40532.60095893656 33063.16986720097 27146.895386785516 0.7854749076491008 0.5542350479543966 0.5468814861941868 0.579972440028455 0.6439521113276818 0.7655378414976081 1.1874433549656658 1.4930842139196105 1.217935583282034 1.0 14.728499595398747 -7.2077147412017615 2.743161398267331 1.28095512819989 0.6157213074821486 0.828148099090523 0.13002556159917444 0.10012355401586868 1.4866955770998436 0.056252647321478284 0.03952770345918737 6.198480778553757e-08 7.2077147412017615 -0.6652338207177415 S(ph)PAPPLLHVAALGQK ddPTM_A459_Selumetinib_30min_R2 2 SPAPPLLHVAALGQK 15 0 Q8N163-2;Q8N163;H0YC69;E5RGU7;E5RFJ3;H0YC58 Q8N163-2 CCAR2 Cell cycle and apoptosis regulator protein 2 1 S(1)PAPPLLHVAALGQK;S(1)PAPPLLHVAALGQK 89.866 0.010686 11509000.0 97909.0 72934.0 95187.0 108436.0 121698.0 89298.0 113499.0 132363.0 103744.0 80279.0 True False 92467.60974078128 78527.80328022742 89062.77205176935 93666.8297374663 106409.20924607594 101597.98893346518 118776.92839400192 132748.15441612585 124495.69884955362 77961.13668010857 1.1860731343643167 1.007268577963967 1.1423996088873511 1.201455413891688 1.3649006899770584 1.3031876298872314 1.5235402336598733 1.7027478057537857 1.5968943521229872 1.0 16.25046750491694 -6.43397406493257 1.1335672350191863 1.4987647768825338 1.0944362211595273 0.3569404766866291 0.18420962610022265 0.44820163555022235 1.209574761417787 0.08168031518298123 0.101933589392606 3.6815095811443675e-07 6.43397406493257 -0.4043285557230065 S(ph)PAPRPPR ddPTM_A459_Selumetinib_30min_R2 2 SPAPRPPR 8 1 F8VP90;P50281 F8VP90 MMP14 Matrix metalloproteinase-14 1 S(1)PAPRPPR;S(1)PAPRPPR 91.867 0.014444 6866800.0 9024.9 7346.3 7708.299999999999 8144.5 7979.700000000001 8634.900000000001 9528.3 17695.6 10531.3 15255.5 True False 8523.332187537157 7909.7375879224355 7212.3563701624635 7035.205049953844 6977.218746576878 9824.279095182188 9971.384829968261 17747.09126633572 12637.854269107642 14815.034076450822 0.5753164078836231 0.5338993853882069 0.48682684987048636 0.47486931272987254 0.47095529518001505 0.6631290245088488 0.6730585146488617 1.1979109312036977 0.8530425379983494 1.0 13.854774324233395 -7.58089749862003 3.9706834342031847 1.0178710376903881 0.5336119566336924 0.8327854009089051 0.09630382382631443 0.08290547112030984 2.6848583837628976 0.04806205733315095 0.026851633462915088 2.624837979685244e-08 7.58089749862003 -0.4842590810566957 S(ph)PAQQEPPQR ddPTM_A459_Selumetinib_30min_R2 2 SPAQQEPPQR 10 0 A0A669KBI3;F5GXF9;P51825;P51825-3;P51825-2 A0A669KBI3 AFF1 AF4/FMR2 family member 1 1 S(1)PAQQEPPQR;S(1)PAQQEPPQR 95.401 0.023481 1457700.0 34961.4 27973.6 30154.3 37595.3 35659.7 24606.4 27498.0 28775.7 23531.4 29570.9 True False 33018.38534957304 30119.085170699153 28214.20516751945 32474.755284490107 31179.809684237196 27995.708245340516 28776.71148625329 28859.432522926414 28238.33752225078 28717.111282574806 1.1497808754046996 1.0488201572340965 0.9824875799621073 1.1308503478967744 1.085757177225438 0.9748789831213968 1.0020754247560635 1.0049559734247353 0.9833279275337649 1.0 14.80962301213981 -6.757763205463219 24.997955509113037 0.9939216410953667 1.0752914812966428 0.49798763925930467 0.043310882137826114 90.5039484920132 615426.5548886129 0.015081664771181192 0.014532058814448865 1.7467743037929013e-07 6.757763205463219 0.08136984020127602 S(ph)PAQSDSTTQR ddPTM_A459_Selumetinib_30min_R2 1 SPAQSDSTTQR 11 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 S(1)PAQSDSTTQR 98.0 0.018683 9370300.0 2447.4 1132.3 3074.9 3722.3 2760.1 3967.4 4945.4 10175.0 4901.6 5851.8 True False 2311.3833057184497 1219.1437690816563 2877.0642816979844 3215.3163186743423 2413.351562392928 4513.873337528611 5175.370899124193 10204.607565438066 5882.056962146933 5682.843329197662 0.4067300771504438 0.21453059647410383 0.5062719689835591 0.5657935882473643 0.42467325291082053 0.7942983953713725 0.9107009641694421 1.795686943014636 1.0350552745182573 1.0 12.472397226814438 -7.181174143741401 1.7589317241665914 1.301906117803052 0.4209119058654404 0.6993807786534221 0.23686883145450732 0.18648055245255915 1.1325952493389468 0.11814240913839867 0.07795598202446817 6.589096321654293e-08 7.181174143741401 -0.8809942119376115 S(ph)PARTPPSEEDSAEAER ddPTM_A459_Selumetinib_30min_R2 1 SPARTPPSEEDSAEAER 17 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 S(0.79)PART(0.21)PPSEEDSAEAER 64.565 0.024989 6102700.0 7656.4 7038.0 6119.7 9584.9 9653.5 7677.5 2484.1 6358.7 5580.4 7854.3 True False 7230.88793899761 7577.791969263184 5725.965164625569 8279.420085125252 8440.74102661502 8735.005935594063 2599.615572150767 6377.202764260545 6696.635929403613 7627.525951077819 0.9479991265025901 0.9934796705860297 0.7506975658098486 1.0854660001458685 1.106615838576372 1.1451951775214544 0.3408202854797793 0.8360774915960011 0.8779564923613711 1.0 12.896999467945545 S(ph)PASDTYIVFGEAK ddPTM_A459_Selumetinib_30min_R2 1 SPASDTYIVFGEAK 14 0 E9PAV3;F8VZJ2;F8W0W4;H0YHX9;Q13765;E9PAV3-2;F8W1N5;F8VNW4 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alpha 1 S(0.996)PAS(0.002)DT(0.001)YIVFGEAK 102.5 0.011559 0.0 4915.6 5892.5 5341.9 6013.8 4886.3 5973.4 6602.7 7525.5 4176.1 4787.2 True False 4642.410630705898 6344.4358026262125 4998.207969820954 5194.710065616357 4272.439309923758 6796.181628873666 6909.73863300184 7547.397959086406 5011.436689983232 4648.981097360648 0.99858668673476 1.3646938264016861 1.075119013208845 1.117386790100208 0.9190055241027624 1.4618647584375084 1.4862909717840507 1.6234520642321535 1.0779645227700236 1.0 12.182698844569407 -6.776232200877465 24.990809871974758 1.378653774753831 1.1100874820387852 0.22632105339472308 0.20670609869540135 309.60825991804177 523045.2030992201 0.07085472003955445 0.06274538167075554 1.6740475866111608e-07 6.776232200877465 -0.26856629271504584 S(ph)PASPHPPPFTHR ddPTM_A459_Selumetinib_30min_R2 1 SPASPHPPPFTHR 13 0 E5RJM0;B7ZLQ8;Q17RY0-2;Q17RY0 E5RJM0 CPEB4 Cytoplasmic polyadenylation element-binding protein 4 1 S(0.886)PAS(0.114)PHPPPFTHR 74.46 0.032486 3370900.0 18849.0 16546.0 22517.0 25424.0 28795.0 15814.0 19470.0 20332.0 21844.0 23891.0 True False 17801.448038525414 17815.024996224583 21068.280734655917 21961.207341153735 25177.51466943384 17992.234954800988 20375.393579073083 20391.162753856195 26213.410372355476 23201.2047537273 0.7672639514836225 0.767849134789545 0.9080683937876664 0.9465546110326725 1.0851813488430615 0.7754870984408909 0.8782041189391148 0.8788837894540943 1.1298297071467491 1.0 14.501912100725603 -5.326667866740007 3.1905990600731364 0.9450823313928192 0.7625645850092574 0.36544670833039805 0.09722546508358289 0.28524034860651676 5.667879726871366 0.02680475339235511 0.06909531382147233 4.713376511802855e-06 5.326667866740007 -0.18251774638356177 S(ph)PASTQVPCSSTTAEVR ddPTM_A459_Selumetinib_30min_R2 1 SPASTQVPCSSTTAEVR 17 0 Q4AC94;Q4AC94-2;Q4AC94-4;Q4AC94-1;Q4AC94-3;H7C288;H7BZB4 Q4AC94 C2CD3 C2 domain-containing protein 3 1 S(0.836)PAS(0.049)T(0.017)QVPCS(0.001)S(0.001)T(0.048)T(0.048)AEVR 67.29899999999999 0.039179000000000005 3832400.0 5530.9 2725.3 7109.8 7673.6 8009.8 4688.3 6564.4 8842.2 5316.3 6845.9 True False 5223.514719946955 2934.3217467793334 6652.363208564939 6628.442442301654 7003.537315479468 5334.070768849974 6869.65760711183 8867.929338094995 6379.7085498330625 6648.241079215673 0.7856987521522308 0.44136813208427006 1.0006200330734323 0.9970219736802393 1.0534421408655823 0.8023281203694348 1.0333045275070376 1.3338760180972844 0.9596084849837769 1.0 12.698756982877864 -5.31924730902288 8.323035111850492 1.027826548800039 0.6142464716499539 0.5583883882678806 0.145443636554021 0.22212698156132837 30.035321812008167 0.03877152082250708 0.08128079638708077 4.794603421586787e-06 5.31924730902288 -0.41358007715008516 S(ph)PATPACR ddPTM_A459_Selumetinib_30min_R2 1 SPATPACR 8 0 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 S(0.999)PAT(0.001)PACR 91.087 0.027357 11444000.0 5258.8 6035.4 6322.2 6257.5 8372.2 4880.9 7593.3 7562.2 6226.8 6160.0 True False 4966.536948644356 6498.295773130292 5915.436535090894 5405.217705210406 7320.409387582365 5553.199670601248 7946.403495838501 7584.204750010398 7472.333991328659 5982.144794397896 0.830226803151835 1.086281926712265 0.9888487722046662 0.903558487964423 1.223709829698157 0.9282957637203395 1.328353587041236 1.2678069506296112 1.2491061731448363 1.0 12.546447115151397 -6.749250003704685 1.1553850488091435 1.2193065181563036 0.9678491025241679 0.3400057009244061 0.13532672486986086 0.5049580633469671 1.4285433083858354 0.06750289387182921 0.06161847400052558 1.7813530278130696e-07 6.749250003704685 -0.25145741563213575 S(ph)PATSPISSNSHR ddPTM_A459_Selumetinib_30min_R2 1 SPATSPISSNSHR 13 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 S(0.987)PAT(0.01)S(0.003)PISSNSHR 69.352 0.042428 2384600.0 7128.8 5986.9 9038.6 11491.0 12367.0 10744.0 8121.5 10211.0 10071.0 9187.0 True False 6732.609834847466 6446.075979082374 8457.066316483591 9925.905976919348 10813.346897617233 12223.888475678632 8499.165842446944 10240.712319477947 12085.481407251064 8921.747439307384 0.7546290545263556 0.7225127165875923 0.947915907059137 1.1125517780505474 1.2120211843226867 1.3701226759482894 0.9526346604479485 1.1478370564895701 1.354609227560614 1.0 13.123110592915241 -5.56493035205348 2.02955632420461 1.178008777354689 0.7303916630560643 0.6554995332377487 0.12469354188233749 0.19892856402024028 1.622708894058781 0.0369755779953683 0.09034582876277887 2.7231379835812095e-06 5.56493035205348 -0.4476171142986247 S(ph)PAVKPAAAPK ddPTM_A459_Selumetinib_30min_R2 1 SPAVKPAAAPK 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 S(1)PAVKPAAAPK 69.229 0.038336 73598000.0 118780.0 115660.0 124850.0 134730.0 128220.0 125640.0 141150.0 145100.0 142480.0 116980.0 True False 112178.68311401397 124530.75009448387 116817.28692640185 116379.54157778659 112111.85729865624 142945.76955363574 147713.75468341893 145522.21697740175 170979.98122382417 113602.4834494586 0.9874668203351552 1.0961974273202155 1.028298707733564 1.0244453998187768 0.9868785777780507 1.2582979281190791 1.3002687106671953 1.280977427242109 1.5050725656001407 1.0 16.79363484819715 -6.816764062071135 5.756382598840786 1.291547015655763 1.0288543352383195 0.5132513278753619 0.1180766683546948 0.14960003619701573 10.329418096889938 0.03964916919158824 0.03534302385551013 1.5248809465498928e-07 6.816764062071135 -0.2626926804174434 S(ph)PCGLTEQYLHK ddPTM_A459_Selumetinib_30min_R1 4 SPCGLTEQYLHK 12 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 S(1)PCGLTEQYLHK;S(1)PCGLTEQYLHK;S(1)PCGLTEQYLHK;S(1)PCGLTEQYLHK 171.81 1.1677e-05 30279500.0 11473.099999999999 16096.300000000001 13270.800000000001 13474.4 11420.5 13471.300000000001 13666.4 14550.599999999999 9484.3 15344.5 True False 11740.400907233596 14211.73771303315 11468.698251286454 11121.348985813966 10387.51779145304 13335.790952961755 12635.532445118237 14164.670820990126 16094.164394135156 17314.116043087146 0.6780826048535745 0.8208179775199869 0.6623900534538383 0.6423284306364742 0.5999450255273281 0.7702264972566254 0.7297821276970772 0.8180995660269661 0.9295400558760221 1.0 14.07966111344277 -8.114789033244108 1.184591547222669 1.00093171118945 0.6914665599926462 0.7746268360027289 0.05811886836951896 0.22502030280004326 0.590598798426884 0.057355305960881994 0.019311113164343353 7.677343402663163e-09 8.114789033244108 -0.30946515119680384 S(ph)PCGLTEQYLHK ddPTM_A459_Selumetinib_30min_R2 2 SPCGLTEQYLHK 12 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 S(0.998)PCGLT(0.002)EQYLHK;S(1)PCGLTEQYLHK 164.66 0.00033882 34901000.0 65728.0 51736.0 59348.0 63815.0 62090.0 44092.0 56356.0 42483.0 54111.0 64534.0 True False 62075.10089003118 55703.984842540514 55529.6142932167 55123.28691298481 54289.69910835729 50165.27277267516 58976.66566729546 42606.61849656075 64934.7119876638 62670.73574053148 0.9904958056824744 0.8888356612433176 0.8860533331397232 0.8795698065713714 0.8662687371842378 0.800457696561418 0.9410559006594377 0.6798487043930693 1.0361249348739994 1.0 15.935504309694704 -3.9324773005231948 1.35080678780962 0.8714853232622254 1.7440940589755194 0.0811633996948451 0.09516174425327872 23.308548029032693 6.701677858434653 0.025020891427847494 48.16002429083916 0.0001168214787905089 3.9324773005231948 0.872608735713294 S(ph)PCHQMSVDYPESEEILR ddPTM_A459_Selumetinib_30min_R2 2 SPCHQMSVDYPESEEILR 18 0 F5H212;P15822;A0A0D9SFF3;P15822-2;P15822-3 F5H212 HIVEP1 Zinc finger protein 40 1 S(1)PCHQMSVDYPESEEILR;S(0.996)PCHQMS(0.004)VDYPESEEILR 122.3 0.00060371 5641200.0 13552.7 10854.7 12762.7 16599.6 14382.1 15304.599999999999 12724.400000000001 14071.3 13526.599999999999 12086.7 True False 12799.49518975666 11687.220586638401 11941.561776977089 14338.705844092807 12575.292020394663 17412.66972867378 13316.10981292027 14112.245153370875 16232.297964782254 11737.725565981984 1.090457867480892 0.9956972090496002 1.0173659036283706 1.2215915053976834 1.0713567930775358 1.4834790292881608 1.134471047058105 1.2022981006022726 1.382916807309445 1.0 13.518865262224812 -5.912809870408718 1.8205906100661617 1.2351949193489593 1.0271918806502007 0.2467017634648334 0.13618404530106135 0.44092296183078716 2.9705357537742616 0.042140580550077335 0.07445010312028467 1.222334668405676e-06 5.912809870408718 -0.20800303869875858 S(ph)PCLEPHILK ddPTM_A459_Selumetinib_30min_R1 2 SPCLEPHILK 10 0 E9PP00;Q9C0D7;Q9C0D7-2 E9PP00 ZC3H12C Probable ribonuclease ZC3H12C 1 S(1)PCLEPHILK;S(1)PCLEPHILK 142.12 0.00081657 9347800.0 13467.900000000001 13649.9 16754.1 17295.7 15226.5 13889.8 12168.5 12267.199999999999 7402.5 9153.0 True False 13781.675866028485 12051.76336233365 14478.985243683741 14275.330675498913 13849.265763456911 13750.08122292935 11250.62024808445 11941.834006518635 12561.501842791302 10327.876707769994 1.3344152196995231 1.1669158824549795 1.401932425547909 1.3822135061661922 1.3409596333617793 1.3313560581706714 1.0893449415038279 1.1562719370511472 1.216271475562918 1.0 13.334256062790681 -7.255448925159231 24.866805295358635 1.128494747405122 1.3256999908050715 0.6344209240781928 0.0781526043867527 321.6849022506323 1335340.5272892565 0.030952263284055204 0.023340872118012987 5.553299223923247e-08 7.255448925159231 0.1972052433999496 S(ph)PCLEPHILK ddPTM_A459_Selumetinib_30min_R2 3 SPCLEPHILK 10 0 E9PP00;Q9C0D7;Q9C0D7-2 E9PP00 ZC3H12C Probable ribonuclease ZC3H12C 1 S(1)PCLEPHILK;S(1)PCLEPHILK;S(1)PCLEPHILK 138.89 0.0015792 7641900.0 112962.0 133747.0 123213.0 125415.0 129962.0 79089.0 64197.0 55773.0 54748.0 119434.0 True False 106684.02426271445 144004.96483561254 115285.60972417107 108333.26064705763 113635.01168497872 89982.7918515402 67182.28770394227 55935.29019628283 65699.12978693085 115985.63009320076 0.9198038082561437 1.2415759152224006 0.9939645939892107 0.9340231247612826 0.9797335376258836 0.7758098290213549 0.5792294066942401 0.4822605192672212 0.5664419784945602 1.0 16.823586549811466 -6.8618880646362275 2.0474063354342396 0.6134073612753007 1.0335191508490549 0.5401108364708147 0.15459846964694768 0.21924163422101248 1.882469077165008 0.06252515697666594 0.05363961135632412 1.3743961671958962e-07 6.8618880646362275 0.42011178957375417 S(ph)PDASSAFSPASPATPNGTK ddPTM_A459_Selumetinib_30min_R1 2 SPDASSAFSPASPATPNGTK 20 0 Q53GS7-2;Q53GS7 Q53GS7-2 GLE1 Nucleoporin GLE1 1 S(0.905)PDAS(0.077)S(0.017)AFS(0.002)PASPATPNGTK;S(0.997)PDAS(0.002)S(0.001)AFSPASPATPNGTK 139.78 7.336e-05 8055800.0 2862.3 3103.9 2366.6000000000004 2346.79 2383.9 2243.9 2763.3 2922.46 1487.74 2572.6 True False 2928.9860209337235 2740.493945036038 2045.2287188032744 1936.967181204234 2168.27666591173 2221.3284032981883 2554.8620562544074 2844.946867312058 2524.5861197695804 2902.81826924605 1.0090146021075133 0.9440804386792796 0.704566572586193 0.667271252122622 0.7469557046969039 0.7652316463734861 0.8801315891256198 0.9800637185775247 0.8697017469251673 1.0 11.503238539622089 -7.4911258731039485 4.320914950422682 0.9428309130158485 0.7994835836873324 0.281857325193859 0.10265655133212383 0.3114337644873308 13.38757498429723 0.05291284074987657 0.03261229616700665 3.2275585314451076e-08 7.4911258731039485 -0.14334732932851613 S(ph)PDASSAFSPASPATPNGTK ddPTM_A459_Selumetinib_30min_R2 2 SPDASSAFSPASPATPNGTK 20 0 Q53GS7-2;Q53GS7 Q53GS7-2 GLE1 Nucleoporin GLE1 1 S(0.993)PDAS(0.003)S(0.003)AFSPASPATPNGTK;S(1)PDASSAFSPASPATPNGTK 160.02 9.8474e-07 19723400.0 106197.0 78833.0 104094.0 119747.0 116264.0 92524.0 114413.0 136985.0 119039.0 97286.0 True False 100294.99588027383 84879.2376119529 97396.70536897787 103437.252024903 101657.87690665245 105268.34115075278 119733.43120505843 137383.60367091233 142850.12622756025 94477.1004006159 1.0615799538193702 0.8984106968994104 1.030902779149464 1.0948394011489866 1.0760054709086917 1.1142207022059127 1.2673275396614296 1.4541471223011488 1.5120079428964883 1.0 16.527677067169307 -7.210124186226661 1.9455677667681264 1.3623064273924848 1.0268062428562101 0.4691072348768883 0.13726576475337385 0.26577335083886955 1.968167587265697 0.06696277986125922 0.044132193002510256 6.16418712125026e-08 7.210124186226661 -0.3355001845362746 S(ph)PDEEDYDYESYEK ddPTM_A459_Selumetinib_30min_R1 2 SPDEEDYDYESYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(1)PDEEDYDYESYEK;S(1)PDEEDYDYESYEK 231.17 2.2021999999999997e-13 55016000.0 7264.5 9703.9 5151.7 4351.0 6035.9 5331.200000000001 9230.2 8352.8 3571.6 7846.4 True False 7433.74871574365 8567.762876779276 4452.1274362625 3591.1795283854212 5489.953910724699 5277.572968342304 8533.958582723344 8131.256610281796 6060.7443406569955 8853.561870408232 0.839633677897468 0.967719320448395 0.5028628592005553 0.40561974727803357 0.62008420916717 0.5960960171275066 0.9639011629033603 0.9184164214697998 0.6845543555655458 1.0 13.112042266294289 -7.257649625774936 24.86325210335118 0.884919355411811 0.6496515250885466 0.32100933105369567 0.1681817668684758 424.64908819205885 2785986.575103507 0.07294679942896617 0.05429905007212981 5.525230165605251e-08 7.257649625774936 -0.23526783032326437 S(ph)PDEEDYDYESYEK ddPTM_A459_Selumetinib_30min_R2 4 SPDEEDYDYESYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(1)PDEEDYDYESYEK;S(1)PDEEDYDYESYEK;S(1)PDEEDYDYESYEK;S(0.999)PDEEDY(0.001)DYESYEK 267.47 3.5299999999999997e-44 74775500.0 87848.0 62364.0 77411.9 81759.0 94229.0 92399.0 140165.0 130248.0 116534.0 81278.0 True False 82965.759843407 67147.11826813429 72431.30263370383 70623.28315785836 82391.11060205191 105126.12353538994 146682.9502316786 130627.00011628275 139844.0562320125 78931.29295439486 1.051113655155037 0.8507033871462202 0.9176500209562435 0.8947437767003674 1.0438332823162555 1.3318687633323074 1.8583624408183645 1.654945652439227 1.771718807555984 1.0 16.26830976140605 -6.871464102135744 2.675912932849459 1.6252075426642607 0.9300454965234288 0.6274576342002294 0.22443391474636895 0.1548914792564141 2.2495901614480864 0.08194747247201316 0.07121290731301458 1.344422889234066e-07 6.871464102135744 -0.6951620461408319 S(ph)PDEVTLTSIVPTR ddPTM_A459_Selumetinib_30min_R2 1 SPDEVTLTSIVPTR 14 0 A0A0C4DGG1;Q9UKS6;H0YDM6 A0A0C4DGG1 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 1 S(1)PDEVTLTSIVPTR 113.37 0.0033171 2358500.0 1820.8 812.65 877.7 938.04 1513.9 849.58 3286.8 1810.2 1113.6 1481.4 True False 1719.6072252399103 874.9776419184032 821.2297375675049 810.2773337907428 1323.7103475622812 966.6019332806262 3439.642712670644 1815.4673823052588 1336.3511165837326 1438.6281328605596 1.1953104391338807 0.6082027884291424 0.5708422620198429 0.5632291731843114 0.9201198818003256 0.6718914438011445 2.390918566169896 1.2619434729775472 0.9289065645661607 1.0 10.49047800654571 S(ph)PDLEASLDTLENNCHVGSDIDFRPK ddPTM_A459_Selumetinib_30min_R2 2 SPDLEASLDTLENNCHVGSDIDFRPK 26 1 Q13111;Q13111-3;Q13111-2;K7EJF1 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(0.691)PDLEAS(0.159)LDT(0.149)LENNCHVGS(0.001)DIDFRPK;S(0.94)PDLEAS(0.059)LDT(0.001)LENNCHVGSDIDFRPK 75.17399999999998 8.4588e-05 4874600.0 15508.2 12853.7 16433.5 18655.9 20958.8 12771.900000000001 12822.8 16187.5 13786.2 17632.5 True False 14646.316328243392 13839.537458840323 15376.186501441949 16114.934236777442 18325.76816995069 14531.113293235272 13419.085607896164 16234.602945015122 16543.825218612314 17123.403910263132 0.8553390672204453 0.8082235010847006 0.8979631959873372 0.9411057708636277 1.0702175961034772 0.8486112556467738 0.7836692796724407 0.9480943759835452 0.9661528341743174 1.0 14.063681898830673 -1.522878745280344 0.061913322167789935 1.1039574893928525 0.49427499230644045 0.18586943650709253 0.07683967831973879 682.7879611869275 3.163737158104427 6.143873760938935 37.270103160128 0.02999999999999955 1.522878745280344 -0.6096824970864121 S(ph)PDLPNAASAPPAAAPEAPR ddPTM_A459_Selumetinib_30min_R2 1 SPDLPNAASAPPAAAPEAPR 20 0 S4R3C3;S4R3I3;Q5JR12 S4R3C3 PPM1J Protein phosphatase 1J 1 S(1)PDLPNAASAPPAAAPEAPR 190.37 2.3171e-17 0.0 16948.0 11455.0 13840.0 16753.0 18418.0 10331.0 19319.0 16345.0 10937.0 11990.0 True False 16006.098008219456 12333.561666369666 12949.549467852648 14471.212499463032 16104.166180990886 11754.001474519344 20217.371779872276 16392.561243939588 13124.705605312754 11643.817546238768 1.3746434916776766 1.0592369398946568 1.1121395037691624 1.242823708117754 1.3830658301746506 1.0094628697025718 1.736318153353663 1.407833915195174 1.1271823483314842 1.0 13.50727651787072 -5.994036975760769 8.31189155407656 1.3078355065941913 1.1707245394785426 0.025131361610702174 0.2175152168530086 0.3600449127239998 221.55430690944178 0.06179373912932107 0.08874607715862555 1.0138250651627475e-06 5.994036975760769 -0.13711096711564874 S(ph)PDPFGAVAAQK ddPTM_A459_Selumetinib_30min_R2 4 SPDPFGAVAAQK 12 0 Q9Y3Q8;Q9Y3Q8-2 Q9Y3Q8 TSC22D4 TSC22 domain family protein 4 1 S(1)PDPFGAVAAQK;S(1)PDPFGAVAAQK;S(1)PDPFGAVAAQK;S(1)PDPFGAVAAQK 145.81 0.00067324 30036300.0 83668.0 67468.0 80257.0 101202.0 85241.0 93819.0 109446.0 123117.0 135937.0 101326.0 True False 79018.0675095413 72642.57865618763 75093.35199721475 87418.11301681257 74532.26351579123 106741.71564591338 114535.45586313485 123475.25008688339 163128.19839712905 98400.45510343532 0.8030254273364905 0.7382341736105604 0.7631402915594149 0.8883913486469298 0.7574381992181374 1.0847685158946674 1.1639728265762486 1.254823973701039 1.6577992269004656 1.0 16.586377367613466 -7.109816273992546 1.376317716602533 1.3351618992598007 0.7802499552279227 0.670522689126055 0.15877935272647423 0.23707100309868623 0.8966296534569039 0.08546009095452536 0.056901981567015 7.765755733795277e-08 7.109816273992546 -0.5549119440318779 S(ph)PDSCRPQALPCLPSTQDVPSR ddPTM_A459_Selumetinib_30min_R1 1 SPDSCRPQALPCLPSTQDVPSR 22 1 Q9Y283-2;Q9Y283 Q9Y283-2 INVS Inversin 1 S(0.795)PDS(0.203)CRPQALPCLPS(0.001)T(0.001)QDVPS(0.001)R 56.172 0.013153 10040000.0 395.09 599.84 453.42 437.29 573.68 546.52 347.51 556.12 158.84 233.9 True False 404.294828288686 529.6104539419496 391.84805445777954 360.9255104499336 521.7907452914301 541.0225050004575 321.2970409180939 541.3698910676554 269.53987878540613 263.923343378936 1.5318646055048164 2.00668287678345 1.4847040411092842 1.3675391719016068 1.9770541650885842 2.049922898345782 1.217387733895072 2.051239136851821 1.021280934587154 1.0 8.043975148955933 -8.281943595345982 24.01313185457281 1.010639866711804 1.7054158080856423 0.48452232914169646 0.28882873411758636 472.2381956421578 553044.5474506757 0.2691429664334466 0.06988310269799491 5.224640404019226e-09 8.281943595345982 0.6947759413738384 S(ph)PDSCRPQALPCLPSTQDVPSR ddPTM_A459_Selumetinib_30min_R2 2 SPDSCRPQALPCLPSTQDVPSR 22 1 Q9Y283-2;Q9Y283 Q9Y283-2 INVS Inversin 1 S(0.734)PDS(0.261)CRPQALPCLPS(0.002)T(0.003)QDVPSR;S(0.759)PDS(0.236)CRPQALPCLPS(0.003)T(0.001)QDVPSR 49.094 0.033675 30089000.0 6897.799999999999 8522.4 8891.2 8183.1 8898.2 7631.5 6820.5 3962.5 6086.3 7684.1 True False 6514.447890081199 9176.040676164894 8319.149872006607 7068.547663365128 7780.328565082701 8682.669853140495 7137.666764564359 3974.030218972814 7303.730065430655 7462.240067310534 0.8729882490136868 1.2296630225502823 1.1148327843873445 0.9472420613121206 1.0426264090813162 1.1635473765010906 0.9565045750580959 0.5325519124453865 0.9787583888416755 1.0 12.86539305842536 -7.528942106670895 24.986140711071855 0.8022987084821179 1.0652965133076289 0.2958363306686804 0.15282140977030612 162.56939385212223 669909.199237208 0.06775009592168756 0.03925108996933869 2.9584068086650065e-08 7.528942106670895 0.26299780482551094 S(ph)PDSFSMR ddPTM_A459_Selumetinib_30min_R2 2 SPDSFSMR 8 0 Q92834-2;Q92834;H7C4H4;A0A2R8YDN2;A0A2R8Y838;A0A2R8YFT6;A0A2R8Y414;Q92834-5;Q92834-3;Q92834-4;Q92834-6 Q92834-2 RPGR X-linked retinitis pigmentosa GTPase regulator 1 S(0.988)PDS(0.012)FSMR;S(0.917)PDS(0.081)FS(0.001)MR 96.665 0.020894 6686500.0 47022.0 41831.0 43986.0 45484.0 51501.0 40523.0 44294.0 40901.0 39398.0 41715.0 True False 44408.70548398015 45039.303192135274 41155.98864833571 39289.00073572355 45030.98395521838 46104.67541883144 46353.7587668959 41020.015138474926 47278.70087209581 40510.579561413695 1.0962248865548054 1.1117911340630433 1.0159318650562277 0.9698454369471994 1.1115857744506417 1.138089751318841 1.1442383512836196 1.0125753712382448 1.1670704636654654 1.0 15.30601110452434 S(ph)PDSTANVR ddPTM_A459_Selumetinib_30min_R1 1 SPDSTANVR 9 0 B7ZM87;O75044;E9PDX4;A0A087WW56;A0A286YEY3;A0A075B7B5;P0DMP2 B7ZM87 SRGAP2;SRGAP2B SLIT-ROBO Rho GTPase-activating protein 2;SLIT-ROBO Rho GTPase-activating protein 2B 1 S(1)PDSTANVR 136.49 0.0026355000000000003 7215800.0 744.29 683.62 843.37 786.92 1058.4 746.89 800.54 738.31 542.15 546.97 True False 761.6305088637672 603.581452593684 728.8449862998046 649.4991943178712 962.6679068756966 739.3769647218611 740.1546232815484 718.7276204311314 919.9889529306724 617.1789274389768 1.2340513828367432 0.977968342338394 1.1809297983069404 1.0523677420630828 1.559787387541484 1.1979945066983295 1.1992545279419489 1.1645368765481632 1.4906357168547948 1.0 9.26954499407112 S(ph)PDVISSASTALSQDIPEIASEALSR ddPTM_A459_Selumetinib_30min_R2 2 SPDVISSASTALSQDIPEIASEALSR 26 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 S(0.847)PDVIS(0.11)S(0.031)AS(0.003)T(0.008)ALSQDIPEIASEALSR;S(0.516)PDVIS(0.192)S(0.192)AS(0.074)T(0.026)ALS(0.001)QDIPEIASEALSR 70.767 0.00050322 25607000.0 10541.5 9063.1 10706.6 12304.7 12802.2 11551.7 8210.2 9716.9 8788.900000000001 11979.1 True False 9955.64563096799 9758.210627540375 10017.74901246468 10628.778633208556 11193.87318287988 13142.841819108036 8591.990568202662 9745.174570280606 10546.925582383956 11633.232257560361 0.8557935929197908 0.8388219551963796 0.8611320388582641 0.9136565313824094 0.9622324161545949 1.1297669923650488 0.7385729415501684 0.8377013674722501 0.9066203913817312 1.0 13.505964380407928 -5.740499636991527 3.8251795580689056 0.9228540434162192 0.8482244718039822 0.11447109765953789 0.09589568081293974 0.5695534715453979 17.94823084948275 0.02900937869323263 0.0498204776293597 1.8176085753573493e-06 5.740499636991527 -0.07462957161223704 S(ph)PEAATPVGK ddPTM_A459_Selumetinib_30min_R2 1 SPEAATPVGK 10 0 A0A2R8YH03;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 1 S(1)PEAATPVGK 90.913 0.031952 0.0 26292.0 19984.0 27736.0 28556.0 28731.0 31760.0 30674.0 36945.0 33514.0 25445.0 True False 24830.79589521512 21516.708541312222 25951.49595667348 24666.62353815236 25121.5549216011 36134.65171142529 32100.401779377928 37052.50383342599 40217.73645939944 24710.33673595041 1.004874848957014 0.8707573988665294 1.0502283410374307 0.9982309752284981 1.0166415451980637 1.4623293926567158 1.299067759472331 1.4994738529612708 1.6275673168341624 1.0 14.592827050433694 -6.735259504683906 7.932535859242843 1.404095787656185 0.9845101954338797 0.5952669494710625 0.1598649568077609 0.12738119507071663 30.908790717690312 0.051296061960748346 0.05034243964263206 1.8396724105517824e-07 6.735259504683906 -0.4195855922223053 S(ph)PEASQTDSPVESPR ddPTM_A459_Selumetinib_30min_R2 2 SPEASQTDSPVESPR 15 0 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 1 S(0.999)PEAS(0.001)QTDSPVESPR;S(1)PEASQTDSPVESPR 143.88 0.00034205 4305300.0 9219.2 9337.1 9621.7 7115.5 10984.5 8165.2 9857.8 12480.900000000001 8619.2 11339.2 True False 8706.833771381689 10053.225546491516 9002.650297314867 6146.356625077856 9604.528907324058 9289.882183694257 10316.20723286013 12517.217352675783 10343.280840569792 11011.807833220228 0.7906815940898521 0.9129495990806453 0.8175451691189007 0.5581605416810522 0.8722027348088371 0.8436291592075104 0.9368313894598104 1.1367086623972917 0.9392899873685014 1.0 13.426763718380593 -7.264452216119249 1.996076168997102 1.029344228043262 0.788068835773451 0.5173336647514135 0.09946374802750503 0.28112702795432915 2.1872233577304208 0.052623164719432895 0.03340116990430256 5.439359757733921e-08 7.264452216119249 -0.2412753922698111 S(ph)PEAVGPELEAEEK ddPTM_A459_Selumetinib_30min_R1 4 SPEAVGPELEAEEK 14 0 Q96N64-3;Q96N64-2;Q96N64 Q96N64-3 PWWP2A PWWP domain-containing protein 2A 1 S(1)PEAVGPELEAEEK;S(1)PEAVGPELEAEEK;S(1)PEAVGPELEAEEK;S(1)PEAVGPELEAEEK 244.56 4.4693e-20 100362400.0 3456.42 4338.01 4433.76 4693.139999999999 3769.41 3574.63 3624.28 3351.46 2223.08 2815.43 True False 3536.947860977448 3830.1137725138633 3831.679744900366 3873.5712001486445 3428.467531043386 3538.672467704356 3350.897641675434 3262.568393723667 3772.4043926609197 3176.8178651105522 1.1133618643429415 1.2056447473990066 1.2061376848140537 1.2193242938760185 1.0792143826363418 1.1139047367391997 1.0547969017917946 1.0269925857427558 1.187478965694384 1.0 11.633366663780498 -6.271854210294131 23.75225008499057 1.079142834500735 1.188942013578254 0.4892886797207928 0.0545263148200477 302.715548905367 690377.1257031708 0.016362252783417474 0.018772109878004095 5.347438391426058e-07 6.271854210294131 0.10979917907751902 S(ph)PEAVGPELEAEEK ddPTM_A459_Selumetinib_30min_R2 3 SPEAVGPELEAEEK 14 0 Q96N64-3;Q96N64-2;Q96N64 Q96N64-3 PWWP2A PWWP domain-containing protein 2A 1 S(1)PEAVGPELEAEEK;S(1)PEAVGPELEAEEK;S(1)PEAVGPELEAEEK 173.03 0.0001118 61722900.0 41328.0 32270.7 35851.0 34266.0 33856.5 28009.0 31168.7 32181.1 28647.4 32465.300000000003 True False 39031.15520909214 34745.75892334489 33544.38569161741 29598.91168785295 29603.14378904975 31866.985509613056 32618.106309607352 32274.7416731321 34377.680475234236 31527.94243402044 1.2379861226521178 1.1020623688354696 1.0639573375844888 0.9388152033643035 0.9389494367100303 1.010753733019595 1.034577704455923 1.0236869006175875 1.0903876948893045 1.0 14.944343399964113 -4.856992027220525 1.6020791783422441 1.0066685855451112 1.297976565484177 0.7200022286848868 0.044016096948707804 0.5044334682849446 1.4100164768875387 0.013711219773116581 0.22173365312127177 1.3899781482023802e-05 4.856992027220525 0.2913079799390659 S(ph)PEDQLGK ddPTM_A459_Selumetinib_30min_R1 2 SPEDQLGK 8 0 Q9UK61-3;Q9UK61;Q9UK61-2 Q9UK61-3 FAM208A Protein FAM208A 1 S(1)PEDQLGK;S(1)PEDQLGK 126.19 0.004898 51070000.0 8845.400000000001 9900.1 7758.9 7321.799999999999 8431.6 8184.8 9884.3 10192.4 5168.0 9416.2 True False 9051.480609847737 8740.991689568376 6705.283996586972 6043.185077208083 7668.963268719883 8102.4683432038 9138.719293104416 9922.064442418858 8769.718544214169 10624.8609915551 0.8519152031299115 0.8226923341882713 0.6310938093135049 0.568777801611838 0.7217942215729093 0.7625952329770563 0.8601260101537416 0.9338535770308107 0.8253960735283554 1.0 13.37515634568393 -7.256591700353198 2.127423963044452 0.9104358729727895 0.7126979768182319 0.5150560472585514 0.08665597137887977 0.3020255576998851 2.673103779889132 0.04712669949382685 0.030509401076236283 5.53870582999198e-08 7.256591700353198 -0.1977378961545576 S(ph)PEDQLGK ddPTM_A459_Selumetinib_30min_R2 3 SPEDQLGK 8 0 Q9UK61-3;Q9UK61;Q9UK61-2 Q9UK61-3 FAM208A Protein FAM208A 1 S(1)PEDQLGK;S(1)PEDQLGK;S(1)PEDQLGK 118.23 0.008469200000000001 44853400.0 130152.0 115616.0 139215.0 144677.0 129495.0 117822.0 128915.0 135343.0 97377.0 134713.0 True False 122918.67287973689 124483.37543596656 130258.05846583117 124971.74301825446 113226.68040001161 134050.91101837365 134909.8029402263 135736.8257227601 116855.12094070949 130823.48566359146 0.9395765007807424 0.9515369110105483 0.9956779381401419 0.95526993784293 0.8654920011164547 1.0246700761595775 1.0312353493404287 1.0375570184072542 0.89322739222221 1.0 16.997262033689296 S(ph)PEGLESPVAGPSNR ddPTM_A459_Selumetinib_30min_R2 2 SPEGLESPVAGPSNR 15 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(1)PEGLESPVAGPSNR;S(1)PEGLESPVAGPSNR 126.12 0.0013752 3339500.0 5638.5 4094.7000000000003 7907.4 11981.3 10076.099999999999 8421.8 3146.3 9195.8 4346.0 7918.299999999999 True False 5325.134742703882 4408.750323464327 7398.64649292616 10349.426271104665 8810.250236523092 9581.826504511371 3292.609184275175 9222.558255553362 5215.321437385868 7689.678104785852 0.6925042466198499 0.5733335340422686 0.9621529525821684 1.3458855013272215 1.1457241924131811 1.2460634078490094 0.4281855676411139 1.1993425641332744 0.6782236351532049 1.0 12.908707491906538 -5.316109999645433 5.802195685288282 1.0156098298742 0.6331436648229176 0.2407203254279905 0.2609179863576155 0.26716613557292357 20.233084216305542 0.06929427133069058 0.14994267712521378 4.829364666879437e-06 5.316109999645433 -0.3824661650512824 S(ph)PEGTPQK ddPTM_A459_Selumetinib_30min_R1 1 SPEGTPQK 8 0 C9J0I9;Q86WB0;Q86WB0-3;F8WAU5;F8WBD7;F8WDK5;F8WF13 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 S(1)PEGTPQK 104.22 0.014781 12095000.0 2354.7 5565.6 3912.7 2553.8 3113.1 3058.6 2700.6 4010.0 4664.6 3598.8 True False 2409.5599285513904 4913.976964622754 3381.3768309226652 2107.8267707632035 2831.520654662445 3027.833260986603 2496.891567734466 3903.641773684277 7915.485511095478 4060.7410352805286 0.593379362933182 1.21011828184293 0.8326994510471336 0.5190744133767664 0.6972916100932387 0.745635644991932 0.6148856935325286 0.9613126618438994 1.9492711902394562 1.0 11.987527310193403 -8.050132739524605 7.935279833939683 1.4731128006034306 0.7575582765420487 0.5190736680665138 0.2773288551614215 0.23990569306574605 34.27830831623258 0.17855830296231745 0.06797461500076746 8.909785742122344e-09 8.050132739524605 -0.715554524061382 S(ph)PEHQPSAMSLLAPPSSR ddPTM_A459_Selumetinib_30min_R2 1 SPEHQPSAMSLLAPPSSR 18 0 H7BYJ3;O14578;O14578-4;O14578-3 H7BYJ3 CIT Citron Rho-interacting kinase 1 S(0.998)PEHQPS(0.002)AMSLLAPPSSR 57.708 0.03918 4743500.0 21753.0 17520.0 20220.0 27364.0 30021.0 17649.0 24371.0 24930.0 17399.0 19945.0 True False 20544.055344158493 18863.72766432096 18919.067213871418 23636.975994467062 26249.493588854784 20079.9895483295 25504.29979022034 25002.542172616322 20879.2861686785 19369.136026666554 1.0606593559916333 0.9739065097353969 0.9767636092711879 1.2203422993118918 1.3552227395540857 1.0367003216191097 1.3167494799513602 1.29084447226732 1.0779668303187524 1.0 14.241471982543658 -5.762733641081316 24.98863270891103 1.2038748270904365 1.0007894634750714 0.33331703175050253 0.11564221349602859 33.516693537183585 647138.9117987155 0.03098375585838294 0.04897565880920389 1.7268966973183913e-06 5.762733641081316 -0.2030853636153651 S(ph)PEHSAEPIR ddPTM_A459_Selumetinib_30min_R1 1 SPEHSAEPIR 10 0 Q9ULH0-2;Q9ULH0-4;Q9ULH0;Q9ULH0-5 Q9ULH0-2;Q9ULH0-5 KIDINS220 Kinase D-interacting substrate of 220 kDa 1 S(1)PEHSAEPIR 123.01 0.004287399999999999 5617700.0 314.97 313.37 324.83 321.5 458.66 289.42 348.37 534.55 189.85 322.08 True False 322.3081881750672 276.6804947182395 280.71987016346975 265.3560603024393 417.17428398299995 286.50869757233454 322.092170425704 520.3719975368898 322.16158390461715 363.422105324873 0.8868700705119383 0.7613199380673535 0.7724347695155378 0.730159383302318 1.1479056388440556 0.7883634302217708 0.8862756714751212 1.4318666638940827 0.8864666710810782 1.0 8.505502364637485 -6.891253750867784 0.8926429063151683 1.092733766054951 0.794813614561155 0.24279183333225973 0.17900923396504595 0.7664779619233489 1.2980788311628781 0.1180283624633356 0.09599378048590888 1.2845359081895234e-07 6.891253750867784 -0.297920151493796 S(ph)PEHSAEPIR ddPTM_A459_Selumetinib_30min_R2 2 SPEHSAEPIR 10 0 Q9ULH0-2;Q9ULH0-4;Q9ULH0;Q9ULH0-5 Q9ULH0-2;Q9ULH0-5 KIDINS220 Kinase D-interacting substrate of 220 kDa 1 S(0.993)PEHS(0.007)AEPIR;S(1)PEHSAEPIR 106.79 0.0077318 17592400.0 78933.0 31794.0 53919.0 68544.0 49869.0 35009.0 88603.0 84763.0 63768.0 48098.0 True False 74546.21985383451 34232.497566176986 50449.91024256843 59208.18895500479 43604.01038548348 39831.171969939765 92723.21506351366 85009.64629672987 76523.38182678833 46709.285766387984 1.5959614588557463 0.7328842007430287 1.080083101567616 1.267589259470352 0.9335190994691026 0.8527463290522479 1.9851130999360584 1.8199731574123712 1.6382905576743925 1.0 15.51142176454694 -7.256035574921373 24.99494498643536 1.6791753041376831 1.0637466318374296 0.3823621330848639 0.3274743373349856 400.7674471891293 1853728.7396246896 0.12212577891321424 0.09177744540999676 5.5458028305065065e-08 7.256035574921373 -0.6154286723002536 S(ph)PEIHR ddPTM_A459_Selumetinib_30min_R2 1 SPEIHR 6 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;Q9NYF8-2;Q9NYF8;Q9NYF8-4;Q9Y2W1;A0A3B3ITZ9 E9PK91;Q9NYF8-2;Q9Y2W1 BCLAF1;THRAP3 Bcl-2-associated transcription factor 1;Thyroid hormone receptor-associated protein 3 1 S(1)PEIHR 89.75200000000002 0.047937 39534000.0 34589.0 19180.0 17646.0 8024.1 25710.0 19515.0 56291.0 138690.0 51249.0 65115.0 True False 32666.681850737707 20651.04432657968 16510.67557151213 6931.203737655425 22480.079949683764 22203.014110468015 58908.64303850039 139093.5649386345 61500.23201670233 63234.960760912145 0.5165921107193947 0.32657637607557194 0.2611004319894824 0.1096103113570659 0.35550081282851886 0.3511192834358888 0.9315834520911728 2.199630762238305 0.9725669357055707 1.0 15.948434782430532 -7.439703792340807 3.762391924362929 1.4607531124273816 0.31342083924216285 0.6723853156565311 0.3348000958645998 0.12187445791788136 3.2312608384307104 0.14523347551600957 0.09115872606839165 3.633257742075282e-08 7.439703792340807 -1.1473322731852187 S(ph)PEIMSTISGTR ddPTM_A459_Selumetinib_30min_R2 3 SPEIMSTISGTR 12 0 Q9UPX8;Q9UPX8-3;H7C1X5;E7EUA2;A6NHU9;A0A0A0MSQ6;A0A590UJ45;Q9UPX8-4 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 S(1)PEIMSTISGTR;S(1)PEIMSTISGTR;S(1)PEIMSTISGTR 115.34 0.0052799 18361600.0 4801.0 5951.0 10480.400000000001 12745.4 7746.9 6558.51 7336.4400000000005 9958.5 9177.0 7166.8 True False 4534.179639925751 6407.422564519065 9806.102474196747 11009.454532958645 6773.665163835282 7461.885220273918 7677.598996880073 9987.477586281582 11012.65642680399 6959.875862417342 0.6514742115459103 0.9206231104089843 1.4089478990780213 1.5818463936129432 0.973245112087763 1.0721290677851565 1.103122979295991 1.4350080064233612 1.5823064440374965 1.0 12.764845858800452 -5.035215836263768 3.674415991366725 1.2712404262447083 0.6823379602746008 0.46143411572904913 0.217649032720166 0.20493353096987227 5.694188585577558 0.059948896059616924 0.22988636126399073 9.221130402632952e-06 5.035215836263768 -0.5889024659701075 S(ph)PEPDGPAPAFLR ddPTM_A459_Selumetinib_30min_R1 4 SPEPDGPAPAFLR 13 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(1)PEPDGPAPAFLR;S(1)PEPDGPAPAFLR;S(1)PEPDGPAPAFLR;S(1)PEPDGPAPAFLR 168.82 0.00026993 27455900.0 3129.2799999999997 4580.61 3275.0899999999997 3531.24 3542.1800000000003 3391.3599999999997 3933.81 3397.1 1641.6499999999999 2744.6000000000004 True False 3202.1861354810762 4044.3100517321836 2830.3507667816343 2914.5752235844043 3221.7904444226724 3357.2459975085085 3637.079544571397 3306.997872664053 2785.76014862794 3096.8961446679264 1.0339985540020231 1.305923693532786 0.9139314444414883 0.9411278542880965 1.0403288628098757 1.0840679960446329 1.174427353927748 1.06784267801743 0.8995329576758058 1.0 11.596607287279168 -5.267672834404525 24.996375303892123 1.023984724437056 1.1699611242758843 0.27300174863802185 0.1002226482053091 638.6965493212447 2561206.9538731365 0.027036071564935732 0.05864227885709721 5.39917203355361e-06 5.267672834404525 0.14597639983882837 S(ph)PEPDGPAPAFLR ddPTM_A459_Selumetinib_30min_R2 3 SPEPDGPAPAFLR 13 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(1)PEPDGPAPAFLR;S(1)PEPDGPAPAFLR;S(1)PEPDGPAPAFLR 144.28 0.00067761 24262800.0 19311.4 12521.6 19137.4 24451.9 22317.9 15014.5 17513.800000000003 14416.0 13671.7 18425.1 True False 18238.149697659264 13481.96645671013 17906.120519225657 21121.509038119766 19514.125877442533 17082.611086939385 18328.22640293632 14457.948173302719 16406.42201921499 17893.119488841006 1.0192828427169134 0.7534721078187692 1.0007265938391994 1.1804263114261397 1.0905938391353427 0.954702789393035 1.0243169959473344 0.808017192436421 0.9169123376975608 1.0 14.12711730851288 -7.7355286569609145 24.98428519628672 0.8968484781571244 1.0019417926465723 0.13074841760058742 0.11109512801011143 434.9023911458327 419352.9819557363 0.05668672162361436 0.03271406500732968 1.8385326341182314e-08 7.7355286569609145 0.10509331448944792 S(ph)PEPDPYLSYR ddPTM_A459_Selumetinib_30min_R2 1 SPEPDPYLSYR 11 0 H3BRT8;H3BQR7;H3BV35;H3BRK0;H3BUL5;H3BVF8;H3BQG1;P49761-2;P49761-3;P49761-1;P49761 H3BRT8 CLK3 Dual specificity protein kinase CLK3 1 S(1)PEPDPYLSYR 157.03 0.00055491 2634200.0 14787.0 11170.0 12459.0 15073.0 16845.0 14060.0 12949.0 14744.0 14906.0 14973.0 True False 13965.197737051056 12026.703082789114 11657.401504333531 13020.031397624682 14728.780503789305 15996.637376027691 13551.154157956718 14786.90259899941 17887.616508438507 14540.690585473978 0.9604219039639125 0.827106732798763 0.801708930934764 0.8954204286990041 1.0129354185215402 1.1001291363704686 0.9319470817633794 1.0169326217402215 1.2301765451434665 1.0 13.827808168791782 -6.262202888642812 3.1503449536438337 1.049591998164409 0.8584150161589887 0.5331932934862501 0.08222223098754625 0.20622644047329697 4.2263046057498075 0.026593805630037604 0.033084141478661226 5.46760474024049e-07 6.262202888642812 -0.19117698200542033 S(ph)PEPDTLPLAAGSDHPLPR ddPTM_A459_Selumetinib_30min_R1 1 SPEPDTLPLAAGSDHPLPR 19 0 H3BVB1;H3BME1;H7C112;H3BPZ0;Q6PCT2-2;Q6PCT2-3;Q6PCT2 H3BVB1 FBXL19 F-box/LRR-repeat protein 19 1 S(0.726)PEPDT(0.274)LPLAAGSDHPLPR 78.378 0.019304 0.0 566.68 692.09 622.06 585.5 785.42 812.92 763.19 679.96 526.05 376.06 True False 579.882541432667 611.0597810560884 537.587668730992 483.2534161961999 714.3788996771633 804.7427628723036 705.6219638522058 661.925251978643 892.6684288281472 424.33096413459924 1.366580783505411 1.4400546571054806 1.2669065285569576 1.1388596568288858 1.6835417635243792 1.8964978540124553 1.662904721768973 1.5599268211043822 2.1037079644863947 1.0 8.729046148095819 -6.281063591079689 22.64576090487039 1.6919534758494936 1.3102976203075052 0.2695766754420674 0.27564540248756386 286.40067704903805 330496.44571606914 0.08086513958456662 0.09188350923727143 5.235237745950815e-07 6.281063591079689 -0.38165585554198844 S(ph)PEPDTLPLAAGSDHPLPR ddPTM_A459_Selumetinib_30min_R2 1 SPEPDTLPLAAGSDHPLPR 19 0 H3BVB1;H3BME1;H7C112;H3BPZ0;Q6PCT2-2;Q6PCT2-3;Q6PCT2 H3BVB1 FBXL19 F-box/LRR-repeat protein 19 1 S(0.81)PEPDT(0.19)LPLAAGSDHPLPR 61.985 0.022216 2679400.0 9110.3 8873.2 10387.0 14967.0 14154.0 10774.0 11289.0 13140.0 10382.0 10282.0 True False 8603.985997420443 9553.74590816511 9718.71172851051 12928.468780484885 12375.84798163454 12258.020703365743 11813.960868729131 13178.235224555894 12458.690097317101 9985.131944155712 0.861679750006343 0.9567971621804066 0.9733183079467331 1.2947719522176075 1.2394275860198436 1.2276273134818565 1.1831552086443717 1.319785787334448 1.2477241329403925 1.0 13.28556577631946 -5.6768588556553725 5.197698746672281 1.2291723961236283 0.9237266529509622 0.6999092198772787 0.08571022377734777 0.10225806466074228 4.645866473268647 0.022279145040395743 0.0390261641891225 2.104462272277431e-06 5.6768588556553725 -0.30544574317266604 S(ph)PEPEATLTFPFLDK ddPTM_A459_Selumetinib_30min_R1 1 SPEPEATLTFPFLDK 15 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(1)PEPEATLTFPFLDK 169.98 5.5634e-05 1995500.0 760.44 911.44 625.24 550.08 642.15 847.08 854.4 908.39 420.78 721.08 True False 778.1567724413386 804.7281810830393 540.3358421974817 454.0188542804536 584.0676458807906 838.5591442871024 789.9519201186133 884.2965463334311 714.0329274447442 813.6376419139947 0.9563922959744203 0.9890498418804754 0.6640988744404696 0.558011123001172 0.7178473755305058 1.0306297313316068 0.9708891027464471 1.0868432097772898 0.877580990187547 1.0 9.668242614971165 -6.76438044422269 24.999712177779443 0.9972226140620598 0.7704087873820019 0.4126809167031127 0.12873781787466423 85.78439752131305 729180.0310800335 0.04981137245130265 0.0458474585056795 1.7203608696429676e-07 6.76438044422269 -0.2268138266800579 S(ph)PEPEATLTFPFLDK ddPTM_A459_Selumetinib_30min_R2 5 SPEPEATLTFPFLDK 15 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(1)PEPEATLTFPFLDK;S(1)PEPEATLTFPFLDK;S(1)PEPEATLTFPFLDK;S(1)PEPEATLTFPFLDK;S(1)PEPEATLTFPFLDK 190.18 1.9918e-05 257964630.0 497163.6 376518.10000000003 439405.1 405303.2 471405.7 322694.1 440972.7 563030.2999999999 458152.2 428051.9 True False 469533.2374155778 405395.82757349184 411134.25425409985 350100.2049729824 412183.5015455714 367142.2831496166 461478.80432082847 564668.6249583159 549795.4418420388 415692.929434598 1.1295194220748723 0.9752290666210953 0.9890335513122664 0.8422087078776367 0.9915576435379837 0.8832055037572633 1.1101435017153305 1.3583791904431624 1.3225999359427147 1.0 18.665158683653864 -7.519976113439634 5.222862472856218 1.2541567511328238 0.9664259153197186 0.5062826686367562 0.11428209590366491 0.12458097749222749 10.71734042539035 0.0514114032324529 0.03110191786078685 3.020117824844717e-08 7.519976113439634 -0.2877308358131052 S(ph)PEPEVLSTQEDLFDQSNK ddPTM_A459_Selumetinib_30min_R1 1 SPEPEVLSTQEDLFDQSNK 19 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 S(1)PEPEVLSTQEDLFDQSNK 205.84 1.7949999999999996e-16 2386000.0 1809.4 1924.7 1245.9 1189.6 1689.1 1093.9 1589.8 1729.8 1278.7 1868.0 True False 1851.5554995204843 1699.3552292312447 1076.713623238824 981.8586915576411 1536.3212032348256 1082.896359181732 1469.8801060446767 1683.9200848177204 2169.8605074471093 2107.7759958608485 0.8784403575885114 0.8062314176498635 0.5108292462544519 0.46582686845555177 0.7288825787236315 0.5137625446481376 0.6973606820322265 0.7989084647156641 1.0294549855905843 1.0 11.04150583720053 -8.034778215097079 2.22860865239897 1.0200982177809081 0.6455515366684489 0.5597495004594593 0.12574133075092891 0.2526236773833027 2.2944777304939894 0.11312426930875757 0.037416225928689296 9.23042684970425e-09 8.034778215097079 -0.37454668111245926 S(ph)PEPEVLSTQEDLFDQSNK ddPTM_A459_Selumetinib_30min_R2 2 SPEPEVLSTQEDLFDQSNK 19 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 S(1)PEPEVLSTQEDLFDQSNK;S(1)PEPEVLSTQEDLFDQSNK 328.0 1.1692999999999993e-154 13562500.0 126844.0 100827.0 119640.0 139061.0 133130.0 118371.0 160965.0 167920.0 136126.0 105115.0 True False 119794.5182767637 108560.10669009651 111942.49265418292 120120.65190639455 116405.01920269938 134675.53078504797 168450.1914460966 168408.61939934746 163355.00367823066 102080.05682843082 1.17353498811336 1.0634800769415411 1.0966147172344174 1.1767298690701664 1.1403306661392731 1.3193128508088645 1.6501772890782787 1.6497700396307298 1.6002636435908981 1.0 16.63934151180733 -6.972602099905623 3.2667846766066795 1.5280457713142253 1.1274096050221423 0.4361231068948568 0.18050161869203743 0.19388333422286047 4.300880655337968 0.0665550106172619 0.055192442951331834 1.0651184315761636e-07 6.972602099905623 -0.400636166292083 S(ph)PEPGQTWTR ddPTM_A459_Selumetinib_30min_R1 4 SPEPGQTWTR 10 0 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(1)PEPGQTWTR;S(1)PEPGQTWTR;S(1)PEPGQTWTR;S(1)PEPGQTWTR 151.55 0.00066774 377177000.0 3232.68 4056.1800000000003 2880.27 2659.8799999999997 3257.51 3242.35 3757.52 3618.59 2043.3000000000002 3181.25 True False 3307.995154299699 3581.2805599330754 2489.1451541906163 2195.3818901314216 2962.8687956601007 3209.7349028182525 3474.0872412032904 3522.6132383631366 3467.330863272606 3589.594425499106 0.9215512289636307 0.9976838983515876 0.6934335356965904 0.6115960829825978 0.825404891040897 0.8941775928827845 0.9678216615572789 0.9813401796425355 0.9659394494937963 1.0 11.80960513334129 -6.990761838773868 2.499037592207086 0.9773992728065451 0.8029509193611876 0.3841873122069167 0.10080925177131472 0.3573660540856399 4.49477493666951 0.047542060053869475 0.03810692593702328 1.0214995066671304e-07 6.990761838773868 -0.17444835344535758 S(ph)PEPGQTWTR ddPTM_A459_Selumetinib_30min_R2 2 SPEPGQTWTR 10 0 Q09666;E9PKR9;E9PLK4;E9PJZ0;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(1)PEPGQTWTR;S(1)PEPGQTWTR 140.45 0.0014164000000000002 299566800.0 135095.6 74350.9 65225.4 57847.9 123886.9 68364.1 71162.2 143775.6 160199.8 50420.4 True False 127587.5273825355 80053.37495417596 61028.86877604592 49968.91622680643 108323.12005906171 77780.63422748903 74471.3833052242 144193.96319266802 192244.23635640318 48964.63204406813 2.6057078764057047 1.6349224248663399 1.2463867536290274 1.0205103998705525 2.212272727007751 1.588506458242891 1.520921942968958 2.9448595276462726 3.926185663631323 1.0 15.579452422688444 -7.762096081738958 24.99824532510236 2.82664220973345 1.661164720227384 0.21099799324319335 0.797721129443097 21.19365067669072 806640.2781310561 0.39028796090375545 0.20512503872914137 1.7294337032362827e-08 7.762096081738958 -1.1654774895060658 S(ph)PEPSPR ddPTM_A459_Selumetinib_30min_R1 2 SPEPSPR 7 0 G5E9Y3;Q8WWN8;Q05CH1 G5E9Y3 ARAP3 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 1 S(1)PEPSPR;S(1)PEPSPR 98.582 0.021764 6032200.0 1540.0 2136.32 1769.1100000000001 1997.74 1961.11 1732.78 1964.16 1687.0800000000002 1208.8600000000001 1291.08 True False 1575.8790036816324 1886.1986612517755 1528.8745790256323 1648.872211224247 1783.7279467620913 1715.3498064383593 1816.0018298457117 1642.3331579918372 2051.3471283588897 1456.802694184167 1.0817381172981357 1.294752315314791 1.0494726465905027 1.131843191810983 1.224412855552143 1.1774757235735227 1.2465667705692307 1.1273545584095521 1.4081159628193007 1.0 10.508589780185675 -6.257340319953871 24.317199597152385 1.2051587331371654 1.1441174111384722 0.055969899911648024 0.11308283180965895 759.502191770207 4505641.889941697 0.03188579380822742 0.03962841645770694 5.52916665257685e-07 6.257340319953871 -0.061041321998693165 S(ph)PESDRPR ddPTM_A459_Selumetinib_30min_R2 2 SPESDRPR 8 1 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 S(1)PESDRPR;S(0.999)PES(0.001)DRPR 110.12 0.0066872 54618000.0 22409.0 12565.800000000001 20402.5 12281.5 20887.1 23144.8 40725.0 58028.0 30789.0 31598.0 True False 21163.597490334552 13529.55645458473 19089.82536256239 10608.738513230788 18263.07576495681 26332.786112424306 42618.79319505659 58196.851872947474 36947.660316537855 30685.683638536466 0.6896896200727414 0.4409077736040302 0.6221085242040535 0.34572273631563666 0.5951660057532894 0.85814565588998 1.3888819847420308 1.8965473462634947 1.2040683450877177 1.0 14.905278104818573 -7.0967343044573346 2.516695557457994 1.454656108761493 0.5285491964647329 0.7357068074787583 0.23381516572337052 0.13466511268180315 1.6704473915162972 0.0978580522569956 0.07317998004124895 8.003237325957635e-08 7.0967343044573346 -0.9261069122967602 S(ph)PESQVIGENTK ddPTM_A459_Selumetinib_30min_R2 1 SPESQVIGENTK 12 0 O95218-2 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 S(0.974)PES(0.026)QVIGENTK 124.16 0.0031194000000000005 3797800.0 16622.0 11168.0 12769.0 14414.0 17049.0 11655.0 17123.0 18631.0 19377.0 13958.0 True False 15698.215783138063 12024.549689220126 11947.456441836017 12450.7883344631 14907.152200006163 13260.370456444003 17919.253428580825 18685.213125471917 23252.94143861619 13554.996272760682 1.1581128808337828 0.8870935444950251 0.8814061030651051 0.9185386763612372 1.0997533234267791 0.9782644118531599 1.3219666806246415 1.3784742355865207 1.7154517028782905 1.0 13.726537096024932 -7.33077549183154 2.743086561512686 1.407432587605378 0.9748445183610053 0.4881755565854834 0.1821635956119246 0.21534714545113917 3.1795758055135783 0.08309739046427246 0.05313896448497098 4.669006818547997e-08 7.33077549183154 -0.43258806924437265 S(ph)PEYTEVELK ddPTM_A459_Selumetinib_30min_R2 1 SPEYTEVELK 10 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 S(0.999)PEY(0.001)TEVELK 98.898 0.016878999999999998 0.0 10744.0 9103.2 12001.0 10651.0 12458.0 11968.0 8579.3 12197.0 12123.0 10806.0 True False 10146.891491639719 9801.386168598547 11228.86872570084 9200.315426000165 10892.914664066913 13616.483365312904 8978.25444956044 12232.491250677956 14547.938744921521 10494.00270264021 0.9669228967405201 0.9339988225972721 1.0700272378313516 0.8767212746843907 1.038013327490981 1.2975490621788293 0.8555605238505971 1.1656649609591159 1.3863097959047954 1.0 13.357277446196566 -6.528562994067061 24.947312511923382 1.1373356196140645 0.9663606972229629 0.2574913249910289 0.1437173966294432 218.43551162048928 958671.1969776349 0.04700759028443642 0.04714138531326667 2.9609904449497777e-07 6.528562994067061 -0.17097492239110157 S(ph)PFEGAVTESQSLFSDNFR ddPTM_A459_Selumetinib_30min_R1 4 SPFEGAVTESQSLFSDNFR 19 0 O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6;O95628-5 O95628-3 CNOT4 CCR4-NOT transcription complex subunit 4 1 S(1)PFEGAVTESQSLFSDNFR;S(0.998)PFEGAVTESQS(0.002)LFSDNFR;S(1)PFEGAVTESQSLFSDNFR;S(0.998)PFEGAVT(0.002)ESQSLFSDNFR 226.14 1.9814e-23 86845700.0 1208.76 1404.16 1480.19 1046.83 1263.92 1518.41 1114.9 1237.63 567.06 987.18 True False 1236.9217561624735 1239.7602944237258 1279.1883281016728 864.0207919328222 1149.5986591632006 1503.1361740059726 1030.8021953888604 1204.8040320111895 962.2594035762553 1113.8941689474902 1.1104481831799433 1.1129964847514782 1.148393055428567 0.7756758370943163 1.0320537544867905 1.3494425376391674 0.9254040681107588 1.0816144527891722 0.8638696838546938 1.0 10.121396453437383 -7.991963620164759 2.081823863299957 0.9424632597241877 1.0708827242794765 0.10383254048950374 0.14518569224475253 0.845968195880091 6.747623766322691 0.12356913368375187 0.04188443055060131 1.0186767166514585e-08 7.991963620164759 0.12841946455528885 S(ph)PFEGAVTESQSLFSDNFR ddPTM_A459_Selumetinib_30min_R2 4 SPFEGAVTESQSLFSDNFR 19 0 O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6;O95628-5 O95628-3 CNOT4 CCR4-NOT transcription complex subunit 4 1 S(1)PFEGAVTESQSLFSDNFR;S(1)PFEGAVTESQSLFSDNFR;S(1)PFEGAVTESQSLFSDNFR;S(1)PFEGAVTESQSLFSDNFR 177.6 7.5392e-13 25989200.0 21025.5 21378.6 25561.8 22925.7 24855.699999999997 17122.4 18683.899999999998 20172.0 21067.3 22559.0 True False 19856.986881745226 23018.269876966435 23917.181617583505 19803.1801109616 21733.10475322268 19480.855178328344 19552.73837144548 20230.69718034563 25281.348669544248 21907.663054678906 0.9063945721725116 1.0506949015746494 1.09172674227685 0.9039385014063449 0.9920320893643221 0.8892256161557013 0.8925068056161073 0.923453000434242 1.1539956866437568 1.0 14.419147976189665 -8.248658672579156 24.93455575208604 1.0769978523849453 0.9590013767332991 0.29606167572336706 0.07438102227930145 866.8473473151854 1691187.2491399976 0.05332337918555983 0.019868234273447503 5.6408081275350525e-09 8.248658672579156 -0.11799647565164617 S(ph)PFEHSVEHK ddPTM_A459_Selumetinib_30min_R2 2 SPFEHSVEHK 10 0 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(1)PFEHSVEHK;S(1)PFEHSVEHK 154.67 0.00036274 57367000.0 213335.0 129572.0 205263.0 222037.0 251077.0 197097.0 241317.0 267322.0 235697.0 211233.0 True False 201478.6947476692 139509.75576035367 192056.6020534563 191795.17756481096 219534.46260314112 224245.32268157415 252538.71866056402 268099.8627624602 282842.98592442134 205134.1544407554 0.9821801508234849 0.6800903347406506 0.93624878108206 0.9349743736614233 1.0701994663036216 1.0931642431408868 1.2310905482758088 1.3069489256597193 1.378819566617362 1.0 17.646208192193264 -6.522719779318705 1.0095225472351201 1.256858487051249 0.8382690853514867 0.6237935071450245 0.11925330314514807 0.3089197274137385 0.6776766488152256 0.058664682633061224 0.06847029849365614 3.001098298955023e-07 6.522719779318705 -0.4185894016997622 S(ph)PFLKPDER ddPTM_A459_Selumetinib_30min_R2 4 SPFLKPDER 9 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 S(1)PFLKPDER;S(1)PFLKPDER;S(1)PFLKPDER;S(1)PFLKPDER 82.48899999999998 0.022663 167418000.0 810190.0 694810.0 762610.0 748770.0 791420.0 721396.0 725290.0 759480.0 586595.0 726940.0 True False 765162.8832475402 748099.6928337255 713544.5028669877 646786.2342997054 691994.7442154305 820761.750819123 759017.4221348703 761689.9610613171 703930.3908337255 705951.353383054 1.0838748018269717 1.059704311421302 1.0107559103719341 0.9161909403533004 0.980230069535612 1.1626321656384333 1.0751695828579597 1.0789553096132658 0.9971372495574323 1.0 19.429209246246195 S(ph)PFNDRFPLK ddPTM_A459_Selumetinib_30min_R2 1 SPFNDRFPLK 10 1 O94913;E9PKN0;E9PQ01 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 S(1)PFNDRFPLK 84.18799999999997 0.021057 7402700.0 46296.0 39068.0 45632.0 47539.0 45017.0 40548.0 45538.0 52069.0 41604.0 42392.0 True False 43723.053657571865 42064.38997658055 42696.08680036505 41064.10619065085 39361.56200291381 46133.11894190403 47655.60723183514 52220.512169513015 49925.9625128858 41168.03281235644 1.0620632240763408 1.021773135682963 1.037117488585706 0.9974755504549054 0.9561195741930029 1.1206053772882083 1.1575876712168642 1.268472370480603 1.212736171787657 1.0 15.329236891612469 -6.9666673381835045 4.020586220754238 1.1785560002830948 1.0157937288819299 0.48831401819597564 0.0696482082453373 0.16576126184666345 5.907692941080689 0.025698433071307845 0.021721528630722384 1.0797734927540167e-07 6.9666673381835045 -0.16276227140116495 S(ph)PFSTTR ddPTM_A459_Selumetinib_30min_R2 1 SPFSTTR 7 0 Q8NG27-3;Q8NG27;K7EPI8;Q8NG27-2 Q8NG27-3 PJA1 E3 ubiquitin-protein ligase Praja-1 1 S(1)PFSTTR 86.13600000000002 0.035301 5374200.0 6394.7 4723.5 8839.6 6677.8 5511.9 2093.0 6976.1 6474.6 2888.9 5318.1 True False 6039.308174012328 5085.777261553656 8270.86975982878 5768.272120152471 4819.445844988799 2381.291751637691 7300.502472879906 6493.440014072269 3466.7607226102255 5164.552634916797 1.1693768271779117 0.9847469124759128 1.6014687707722486 1.1168967629749795 0.9331777959634334 0.46108383822794646 1.4135788690625903 1.2573092914517041 0.671260604291639 1.0 12.334427669698272 -6.001767691833506 24.97253859361855 0.9723307834197125 1.247490808596188 0.17551576503484478 0.288212491674584 134.29151944593633 1897235.76888494 0.08449476791794841 0.12325068223453618 9.959380114196576e-07 6.001767691833506 0.27516002517647553 S(ph)PFSVAVSPSLDLSK ddPTM_A459_Selumetinib_30min_R2 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 S(0.956)PFS(0.044)VAVSPSLDLSK 188.63 2.5198e-05 9996600.0 21625.0 24107.0 29577.0 24947.0 26611.0 22729.0 22077.0 20980.0 19143.0 20086.0 True False 20423.169071733893 25955.929383777704 27674.048021002724 21549.17556402461 23267.888274641584 25859.713436680893 23103.6242447456 21041.048326574026 22972.134900109915 19506.064990304578 1.047016355266178 1.3306594331906003 1.4187406857691705 1.1047423237201122 1.192854032128305 1.3257268162253317 1.1844328549212348 1.0786926187845887 1.1776919082105046 1.0 14.251635148190653 -8.350567448719922 0.6524919595899474 1.005601396303138 1.2468810190775976 0.2821393930935635 0.1094144703583188 0.9446418347001356 0.9391687522417682 0.11067755790439304 0.0478181428860846 4.461003369557275e-09 8.350567448719922 0.24127962277445958 S(ph)PGAFDMSGVR ddPTM_A459_Selumetinib_30min_R1 4 SPGAFDMSGVR 11 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 S(1)PGAFDMSGVR;S(1)PGAFDMSGVR;S(1)PGAFDMSGVR;S(1)PGAFDMSGVR 179.6 5.2501e-05 123210000.0 3087.09 4233.950000000001 2432.4300000000003 2174.78 2912.51 2638.02 4309.599999999999 4239.21 2223.07 3215.37 True False 3159.013190568527 3738.2371656900473 2102.1193663815816 1794.9954986766386 2649.0739847454042 2611.4839139305177 3984.523402321132 4126.772379905267 3772.387423391294 3628.0940598560474 0.8707087353446035 1.0303583931444076 0.5794004597733576 0.4947488871740715 0.7301558176390036 0.7197949862507518 1.098241483430346 1.1374491156574387 1.0397711198096589 1.0 11.824996143485748 -7.260895441800778 24.94078355851548 1.0803195365505178 0.7322802364878342 0.5682745226903502 0.14129656500720536 38.53143219985304 1766812.7072317528 0.06305857137113023 0.04583046528668572 5.4840898076703375e-08 7.260895441800778 -0.3480393000626836 S(ph)PGAFDMSGVR ddPTM_A459_Selumetinib_30min_R2 5 SPGAFDMSGVR 11 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 S(1)PGAFDMSGVR;S(1)PGAFDMSGVR;S(1)PGAFDMSGVR;S(1)PGAFDMSGVR;S(1)PGAFDMSGVR 179.67 5.2145e-05 270161200.0 186742.0 130412.0 171353.8 207259.0 204006.9 128184.2 164490.0 165311.1 219651.9 159099.0 True False 176363.62722745544 140414.18105932765 160329.08306391092 179029.9666582828 178377.72937717396 145840.41000968774 172139.11093075137 165792.1279322742 263588.4175868705 154505.39848115423 1.1414722654429927 0.9087978959936124 1.0376924343097762 1.1587295228400705 1.1545080698195251 0.9439178918235442 1.1141300732721517 1.0730507125451454 1.7060142893260888 1.0 17.23729772179574 -8.058813968253462 24.99679604010178 1.3651829840675842 1.0631627952404388 0.29412132569447347 0.17732123226133759 285.54487351952554 121358.78070120238 0.10967456919070834 0.041453285646431054 8.733453892023202e-09 8.058813968253462 -0.30202018882714543 S(ph)PGALETPSAAGSQGNTASQGK ddPTM_A459_Selumetinib_30min_R1 4 SPGALETPSAAGSQGNTASQGK 22 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 S(1)PGALETPSAAGSQGNTASQGK;S(0.997)PGALET(0.003)PSAAGSQGNTASQGK;S(1)PGALETPSAAGSQGNTASQGK;S(0.98)PGALET(0.02)PSAAGSQGNTASQGK 285.96 3.3972999999999984e-79 42742000.0 6407.589999999999 8282.71 5823.349999999999 6185.620000000001 6055.28 5425.4 6698.6 6235.07 3555.1500000000005 5474.37 True False 6556.874380000254 7312.966462672589 5032.5710553718645 5105.417585468039 5507.580993146514 5370.8254018690595 6193.319208926197 6069.695689238304 6032.829892117457 6177.058714379419 1.061488109986177 1.183891363319717 0.8147196405397069 0.8265127177087156 0.8916186890575534 0.8694794157236114 1.0026324008397274 0.9826190699966657 0.976650890183994 1.0 12.592704328570415 -5.25448457338495 24.99967353759181 0.9166271694212157 1.1226897470393156 0.5606313840899483 0.07151999558892502 409.60006041537457 1472334.8588397908 0.019738816015557263 0.04987659076820029 5.5656440368355664e-06 5.25448457338495 0.20606257761809987 S(ph)PGALETPSAAGSQGNTASQGK ddPTM_A459_Selumetinib_30min_R2 4 SPGALETPSAAGSQGNTASQGK 22 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 S(1)PGALETPSAAGSQGNTASQGK;S(1)PGALETPSAAGSQGNTASQGK;S(0.894)PGALET(0.091)PS(0.015)AAGSQGNTASQGK;S(0.974)PGALET(0.003)PS(0.023)AAGSQGNTASQGK 177.29 4.4716e-16 119303200.0 151598.0 137873.0 154354.4 142786.6 146120.3 137329.6 131064.6 131283.7 124178.1 138276.4 True False 143172.79005487703 148447.415768432 144423.40595236357 123338.81875937598 127763.36158194403 156245.50584601218 137159.3635995779 131665.7138318134 149017.18982601157 134284.00104676653 1.0661939541480807 1.1054735829380957 1.0755071700765442 0.9184922835030904 0.951441427020397 1.163545207381758 1.0214125475142044 0.9805018677240539 1.109716635372772 1.0 17.034927902914475 -5.549920145889334 24.99824992187391 1.0210088571549119 1.0869980706755669 0.14790203832433702 0.06811127903477145 400.2371806100033 369994.61532410985 0.019180559787076213 0.033222430044564995 2.818901197473401e-06 5.549920145889334 0.06598921352065501 S(ph)PGAPCQECSR ddPTM_A459_Selumetinib_30min_R1 4 SPGAPCQECSR 11 0 Q9NWF9-3;Q9NWF9;Q9NWF9-1 Q9NWF9-3 RNF216 E3 ubiquitin-protein ligase RNF216 1 S(1)PGAPCQECSR;S(1)PGAPCQECSR;S(1)PGAPCQECSR;S(1)PGAPCQECSR 122.64 0.0040935 13083000.0 803.505 1199.4799999999998 1181.7 1156.77 1173.3310000000001 761.864 757.0699999999999 817.43 522.6700000000001 578.7139999999999 True False 822.2251031514355 1059.044323976876 1021.2316306134667 954.761834762217 1067.2034182184136 754.2003398771653 699.9636003794462 795.7491010131511 886.9328156935803 652.9975790517213 1.2591549027570137 1.6218196788950014 1.5639133488006072 1.4621215535725502 1.6343145096620406 1.154981831590264 1.0719237296345396 1.2186095730534445 1.3582482449346567 1.0 9.350933832853398 -6.772354667936522 24.999396192999157 1.1688638813253003 1.5151014739072564 0.6356314426972658 0.13143245213501376 139.60041957610173 319726.41608692106 0.04533760570373183 0.04036820428351771 1.6890609913529406e-07 6.772354667936522 0.3462375925819561 S(ph)PGAPCQECSR ddPTM_A459_Selumetinib_30min_R2 2 SPGAPCQECSR 11 0 Q9NWF9-3;Q9NWF9;Q9NWF9-1 Q9NWF9-3 RNF216 E3 ubiquitin-protein ligase RNF216 1 S(1)PGAPCQECSR;S(1)PGAPCQECSR 90.759 0.027375 12841900.0 3805.6000000000004 2449.04 3719.0 4453.8 4014.25 2463.6 3139.42 3158.83 1305.9 1160.3 True False 3594.099987023835 2636.87349309524 3479.723588941041 3847.1847567664595 3509.9440271496733 2802.9385376658456 3285.409250642713 3168.0216723275416 1567.1164898946638 1126.7991241785521 3.189654579864863 2.3401451390171673 3.088149000362238 3.414259626418414 3.114968721428904 2.4875228224100865 2.9157009267626197 2.8115230162581653 1.39076828892382 1.0 10.138014632131737 -8.311864363621828 3.0985627686893737 1.0135375818863612 2.928709740609876 0.8417341826585031 0.30179537690919517 0.09525019847562752 1.7135825879748277 0.29440605070586257 0.0817024663621425 4.876807760029905e-09 8.311864363621828 1.9151721587235149 up S(ph)PGAPGPLTLK ddPTM_A459_Selumetinib_30min_R1 3 SPGAPGPLTLK 11 0 Q15942;Q15942-2;H0Y2Y8;C9JJK5 Q15942 ZYX Zyxin 1 S(1)PGAPGPLTLK;S(1)PGAPGPLTLK;S(1)PGAPGPLTLK 136.93 0.0013747 948649900.0 10597.699999999999 12436.599999999999 14201.6 14837.4 13134.5 11057.4 11304.5 10742.0 6334.6 8550.7 True False 10844.605790465472 10980.517090381514 12273.10072380487 12246.326622492734 11946.486794084318 10946.17259531591 10451.79246369483 10457.087265066455 10749.353539121337 9648.265635871185 1.1239953583104538 1.138081962581665 1.2720525312005133 1.269277514184751 1.238200443991571 1.1345223077834061 1.0832819968011889 1.0838307795121396 1.1141228843406248 1.0 13.236053912700088 -6.993008337873441 3.249364480311757 1.0783223495264629 1.2110214572854092 0.5950710748997021 0.05339048786077047 0.2005601644000034 4.40961006064495 0.02286301958159163 0.018686446739134856 1.016229182441711e-07 6.993008337873441 0.13269910775894633 S(ph)PGAPGPLTLK ddPTM_A459_Selumetinib_30min_R2 5 SPGAPGPLTLK 11 0 Q15942;Q15942-2;H0Y2Y8;C9JJK5 Q15942 ZYX Zyxin 1 S(1)PGAPGPLTLK;S(1)PGAPGPLTLK;S(1)PGAPGPLTLK;S(1)PGAPGPLTLK;S(1)PGAPGPLTLK 112.02 0.0079105 743915700.0 724418.0 745108.0 800242.0 836469.0 805742.0 633036.0 701015.0 690853.0 663276.0 816926.0 True False 684157.7476350209 802255.3877001635 748755.3009576118 722540.4792104895 704517.4865351258 720230.9628713416 733613.5865348696 692863.2678531294 795949.7334798765 793339.2237513481 0.8623773124439044 1.0112387786735855 0.9438021952539812 0.9107585476410925 0.888040658324917 0.9078474142066113 0.9247161423154366 0.8733505757812999 1.0032905340494631 1.0 19.597578353958056 -8.281984742413838 24.47524109728061 1.0016453183735257 0.9184266212112794 0.43232959387634307 0.03945933362482416 712.0791695504997 848274.0381650218 0.03822869122117275 0.009920362754816493 5.22414542087191e-09 8.281984742413838 -0.08321869716224628 S(ph)PGASNFSTLPK ddPTM_A459_Selumetinib_30min_R1 3 SPGASNFSTLPK 12 0 Q9Y4E8 Q9Y4E8 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 S(1)PGASNFSTLPK;S(1)PGASNFSTLPK;S(1)PGASNFSTLPK 191.06 0.00010427 208540000.0 7858.6 9741.5 7819.6 8290.9 8199.6 7493.6 8999.599999999999 7820.1 5109.9 7322.200000000001 True False 8041.69008982628 8600.960651299516 6757.741269988207 6843.049954468102 7457.947627756958 7418.221187644418 8320.752926380466 7612.685544735264 8671.12708767028 8262.075694267833 0.9733256372131214 1.0410169271708318 0.8179229433442105 0.8282482765457789 0.9026723917491131 0.897864103664788 1.007101996433335 0.9214010893191028 1.0495095189803507 1.0 13.012288562387539 -7.257334205040334 24.274739957475898 0.9879532438627148 0.9078641504833362 0.2712738028773388 0.06730534670377171 381.34813427464485 2255000.2391338567 0.02861067286563471 0.021320690459171492 5.529244504392717e-08 7.257334205040334 -0.08008909337937853 S(ph)PGASNFSTLPK ddPTM_A459_Selumetinib_30min_R2 4 SPGASNFSTLPK 12 0 Q9Y4E8 Q9Y4E8 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 S(1)PGASNFSTLPK;S(1)PGASNFSTLPK;S(1)PGASNFSTLPK;S(0.999)PGAS(0.001)NFSTLPK 192.39 0.00014888 204112900.0 142100.0 131015.0 143933.0 160319.0 156120.0 132533.0 144002.0 156171.0 128434.0 148388.0 True False 134202.65087137025 141063.4292203774 134672.50748240144 138483.27563429932 136506.80986949182 150788.21773521166 150698.37833454978 156625.43175449935 154124.38874579282 144103.65288167426 0.9312924980573957 0.9789025218965599 0.9345530442103582 0.9609976767765219 0.9472820927140526 1.0463871992129594 1.045763763242633 1.0868942502318586 1.0695383889563628 1.0 17.13674738127134 -6.787182283746636 5.637116489746641 1.0557914977594247 0.9516037530991903 0.8033655931466157 0.02444187418187816 0.07126335967659544 6.458590193604725 0.008289972036443004 0.007537103499368857 1.63236666088931e-07 6.787182283746636 -0.1041877446602344 S(ph)PGDFTSAAQLASTPFHK ddPTM_A459_Selumetinib_30min_R1 1 SPGDFTSAAQLASTPFHK 18 0 O43683-2;O43683-3;O43683;A0A590UJ99 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 S(0.645)PGDFT(0.346)S(0.008)AAQLASTPFHK 110.33 0.00091643 9926400.0 2425.8 2423.9 2193.1 2687.0 2729.1 2274.9 2971.5 2674.2 1149.8 2031.5 True False 2482.3164202148723 2140.1086611594615 1895.289065835994 2217.7658912368715 2482.2533868617397 2252.0165714439363 2747.3573626316243 2603.2715289741873 1951.1266219306212 2292.262813485716 1.082910914756826 0.9336227279738128 0.8268201423875712 0.9675007063716393 1.082883416446963 0.9824425708060153 1.1985350660790381 1.1356775992956663 0.8511792847015007 1.0 11.162556746721958 -6.136209474566205 5.244666623910485 1.0530335640010546 0.9392427337291214 0.14081389280661183 0.10531844355115279 0.38906927589674245 15.024718752770868 0.03192490718472379 0.041716811565836134 7.307865160002931e-07 6.136209474566205 -0.11379083027193326 S(ph)PGDFTSAAQLASTPFHK ddPTM_A459_Selumetinib_30min_R2 1 SPGDFTSAAQLASTPFHK 18 0 O43683-2;O43683-3;O43683;A0A590UJ99 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 S(0.991)PGDFT(0.008)S(0.001)AAQLASTPFHK 100.58 0.0018206 3593000.0 58160.0 50858.0 58538.0 68033.0 73978.0 40587.0 45378.0 41960.0 37797.0 66046.0 True False 54927.70003292679 54758.64506575546 54771.72881135537 58766.788036528895 64684.222268288795 46177.49083789728 47488.16691480114 42082.09665314805 45357.45613641827 64139.08037188362 0.8563842779542754 0.8537485219348386 0.8539525121623888 0.9162399537971899 1.0084993718844175 0.7199587298439021 0.7403936358217311 0.6561069539686666 0.7071734716717489 1.0 15.968916048071224 -6.786066770482424 24.999828426842218 0.7417123764226459 0.8939119676780516 0.3065036893107409 0.09693075879374603 245.7032924887036 249417.19608570824 0.03310746470170849 0.02921062479759319 1.6365648888782374e-07 6.786066770482424 0.15219959125540572 S(ph)PGEPGGAAPER ddPTM_A459_Selumetinib_30min_R1 2 SPGEPGGAAPER 12 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 S(1)PGEPGGAAPER;S(1)PGEPGGAAPER 141.58 0.00097987 164615200.0 786.46 1195.6 1432.41 1143.62 1250.23 1032.69 1268.15 891.37 573.27 1052.7 True False 804.7829878152315 1055.6185961806398 1237.8965896649204 943.9082354061445 1137.146917246035 1022.302076207498 1172.4924245065772 867.7279720221825 972.7973200158006 1187.8242991663358 0.6775269611676251 0.8886992772597063 1.042154627190004 0.7946530779582623 0.9573359612563337 0.8606509202791961 0.9870924726236707 0.7305187919048212 0.8189740862335868 1.0 10.214105735726829 S(ph)PGEPGGAAPER ddPTM_A459_Selumetinib_30min_R2 2 SPGEPGGAAPER 12 0 Q96EB6;Q96EB6-2 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 S(1)PGEPGGAAPER;S(1)PGEPGGAAPER 119.21 0.0043318 323940000.0 29894.0 23882.0 27141.0 29541.0 26393.7 16962.9 31520.5 26551.0 27202.0 21858.6 True False 28232.6111551636 25713.672607266748 25394.777608886452 25517.46483893258 23077.887443328218 19299.38550112518 32986.26570668582 26628.259014245337 32643.160087383898 21227.485422536673 1.3300026165694485 1.2113386063130778 1.1963158661235247 1.2020955064155336 1.0871700997060643 0.9091696504304518 1.5539412723687545 1.2544236156193425 1.5377780004374657 1.0 14.373645861329814 -7.271133214840396 24.994028705891456 1.3577376673856842 1.1593271369063411 0.1964018613559083 0.17674232156214104 1048.9080519576435 2704433.5063707 0.07090020639147694 0.04847903316382123 5.356323332508554e-08 7.271133214840396 -0.1984105304793431 S(ph)PGEYINIDFGEPGAR ddPTM_A459_Selumetinib_30min_R1 2 SPGEYINIDFGEPGAR 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(1)PGEYINIDFGEPGAR;S(1)PGEYINIDFGEPGAR 129.42 0.00087194 43982000.0 3151.9 4204.700000000001 2796.3 3179.1000000000004 3375.1 3805.3 3589.0 3652.1000000000004 2453.09 3655.3 True False 3225.3331374702184 3712.411769288001 2416.5778189764214 2623.9298640979305 3069.8228009223017 3767.022136935956 3318.2788404795238 3555.23444430732 4162.714563395189 4124.493360637132 0.7819949883425159 0.900089161184763 0.5859090093439064 0.6361823464525103 0.7442908819346699 0.9133296644109627 0.804530047774627 0.861980886728382 1.009266884297312 1.0 12.010001198932835 -7.71799926116354 0.8116160531617028 1.0082396738241812 0.7332694430114008 0.5249952454492752 0.09271573060159025 0.5576070343529375 0.6845659106396488 0.09133727702081675 0.04172690604185588 1.9142591816207718e-08 7.71799926116354 -0.2749702308127804 S(ph)PGEYINIDFGEPGAR ddPTM_A459_Selumetinib_30min_R2 1 SPGEYINIDFGEPGAR 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(1)PGEYINIDFGEPGAR 108.77 0.0030872 3150600.0 6074.9 4117.4 5945.6 4711.4 7334.4 5431.3 6796.1 4424.4 5563.1 4395.9 True False 5737.281377751501 4433.191340472322 5563.066569079822 4069.6991923816713 6412.987101632074 6179.412274567507 7112.132116216672 4437.274271501152 6675.875446001231 4268.9789450801445 1.3439469839417986 1.038466433661245 1.303137504459016 0.9533191062166899 1.5022297331831134 1.4475152850517272 1.6660030906015986 1.0394228522993683 1.5638108156272248 1.0 12.059675331786554 -5.482350222561566 18.372360129997123 1.3241759199834646 1.186103436085728 0.034301269228307785 0.243229694126117 79.14802959080399 35873.99972572969 0.06281562412814601 0.13059916156544468 3.2934401636519958e-06 5.482350222561566 -0.13807248389773652 S(ph)PGFASPK ddPTM_A459_Selumetinib_30min_R2 2 SPGFASPK 8 0 P49790-3;P49790 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 S(1)PGFASPK;S(1)PGFASPK 94.692 0.022491 10267600.0 61840.0 58667.0 55112.0 69263.0 69467.0 68652.0 70417.0 74458.0 74049.0 72629.0 True False 58403.18036513403 63166.570255862884 51566.15392140858 59829.25991466063 60739.93441714048 78108.18983919299 73691.53002863843 74674.66045281453 88860.86910192945 70532.01205719565 0.8280379172761138 0.8955730655271822 0.731102834264712 0.8482568151627948 0.8611683212423517 1.1074147406407984 1.0447955173727452 1.0587343005649623 1.259865790158809 1.0 16.105990575415433 -6.720799225984494 4.756961674686111 1.0957864198036746 0.8279870959041423 0.7568566625913666 0.07417446675537069 0.09736040294580377 4.9440434615586035 0.025090976163788078 0.024326441631606483 1.9019573501772248e-07 6.720799225984494 -0.2677993238995323 S(ph)PGGAGAGATGGSTAR ddPTM_A459_Selumetinib_30min_R1 2 SPGGAGAGATGGSTAR 16 0 F8W8C1;Q6ZTA4-2;Q6ZTA4 F8W8C1 TRIM67 Tripartite motif-containing protein 67 1 S(1)PGGAGAGATGGSTAR;S(1)PGGAGAGATGGSTAR 122.96 0.0014045 2370090.0 140.06 159.77100000000002 0.0 271.163 0.0 223.33999999999997 135.733 0.0 73.274 303.87 True False 143.32312549068146 141.06493704447726 0.0 223.80947240992333 0.0 221.0934023764951 125.49455053073478 0.0 124.34062627878278 342.8746744444518 0.41800440852886867 0.4114183623303179 0.0 0.6527442505707202 0.0 0.6448227846945105 0.3660070570510037 0.0 0.36264161673721657 1.0 8.421537537026628 -10.876479503249877 2.4748792602446086 1.0172507835417666 0.3129972109414884 0.43463932039039166 0.2335435288155579 1440169.4832273042 1462214.0625262912 179267.3564640609 0.05763124730301882 1.3289862778334532e-11 10.876479503249877 -0.7042535726002781 S(ph)PGGAGAGATGGSTAR ddPTM_A459_Selumetinib_30min_R2 1 SPGGAGAGATGGSTAR 16 0 F8W8C1;Q6ZTA4-2;Q6ZTA4 F8W8C1 TRIM67 Tripartite motif-containing protein 67 1 S(1)PGGAGAGATGGSTAR 101.01 0.005706899999999999 2443400.0 0.0 0.0 0.0 0.0 0.0 559.59 0.0 638.38 638.35 0.0 True False 0.0 0.0 0.0 0.0 0.0 636.668443047748 0.0 640.2375801105015 766.0378369892479 0.0 0.0 S(ph)PGGGSEANGLALVSGFK ddPTM_A459_Selumetinib_30min_R1 1 SPGGGSEANGLALVSGFK 18 0 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 1 S(1)PGGGSEANGLALVSGFK 194.08 2.6922000000000003e-10 30164000.0 1170.4 1576.6 1400.8 1611.9 1515.8 1282.3 1720.9 1229.7 702.73 1296.8 True False 1197.6680427980414 1392.0109390585442 1210.5790540436192 1330.4119241104252 1378.6961576362257 1269.4012262352455 1591.0911274954615 1197.0843613714605 1192.4814846315064 1463.2569119016857 0.8184947107077196 0.9513100042353133 0.8273181860253918 0.9092128069167212 0.9422105895569886 0.8675176695974048 1.087362796344245 0.8180958187415629 0.8149501806089043 1.0 10.514967378121048 -5.976567650376848 24.381076662951223 0.9188550503024558 0.8732674461954991 0.0796230161313548 0.08385168086327481 579.6605941047902 603123.4506882948 0.023635165973808492 0.03505422297749767 1.0554370841850186e-06 5.976567650376848 -0.045587604106956725 S(ph)PGGGSEANGLALVSGFK ddPTM_A459_Selumetinib_30min_R2 4 SPGGGSEANGLALVSGFK 18 0 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 1 S(1)PGGGSEANGLALVSGFK;S(1)PGGGSEANGLALVSGFK;S(1)PGGGSEANGLALVSGFK;S(0.999)PGGGS(0.001)EANGLALVSGFK 238.72 6.1814999999999995e-25 43523500.0 158113.0 115178.0 142747.0 145094.0 150908.0 105831.2 116268.0 117713.4 101288.8 114952.0 True False 149325.71243648842 124011.7822443582 133562.8134311822 125331.94689888919 131949.5879053627 120408.48716001857 121674.69238067135 118055.92650549764 121549.39024553396 111633.03707883536 1.3376480327327693 1.1108878293509201 1.1964452184245424 1.1227137608948115 1.1819940705561902 1.0786097942940134 1.089952361456802 1.057535740267699 1.088829914747331 1.0 16.7684045211058 -1.5228787452803376 0.19368515999009614 1.0096907088578555 2.168423443560305 0.6852717223487861 0.04974328884397511 31.859535576968554 0.37709943026479176 0.09287857109337146 11.09554139237311 0.029999999999999995 1.5228787452803376 1.1587327347024496 S(ph)PGGPGSHVR ddPTM_A459_Selumetinib_30min_R2 3 SPGGPGSHVR 10 0 O75382-3;O75382-2;O75382;A0A1W2PPI7;O75382-4 O75382-3 TRIM3 Tripartite motif-containing protein 3 1 S(1)PGGPGSHVR;S(1)PGGPGSHVR;S(1)PGGPGSHVR 120.53 0.0033472000000000003 14082300.0 11663.1 9982.18 9238.5 12317.5 12405.6 10671.0 15053.599999999999 14654.3 8276.08 13284.6 True False 11014.911593088531 10747.781108232384 8644.104968118258 10639.835251127324 10847.097620528863 12140.833388306639 15753.622228142505 14696.941586850044 9931.527252995964 12901.039080464014 0.8538003430877411 0.8330942214187772 0.6700316861459623 0.8247269994894582 0.8407925557682074 0.9410740726064034 1.221112666188117 1.1392060356677438 0.7698238251239182 1.0 13.655199647977925 -6.848462997605933 3.036690367355527 1.0473601729317032 0.7960473431558946 0.44595823228120635 0.11927015829986118 0.22815281990468256 4.2334788833513235 0.04587767665677331 0.040610594158188976 1.4175454828186892e-07 6.848462997605933 -0.2513128297758086 S(ph)PGHMVILDQTK ddPTM_A459_Selumetinib_30min_R1 6 SPGHMVILDQTK 12 0 Q9NWH9;Q9NWH9-3;H7C3F4 Q9NWH9 SLTM SAFB-like transcription modulator 1 S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK 203.11 3.5032e-05 177680700.0 38028.700000000004 60351.299999999996 41341.0 44884.4 42923.3 42175.9 50464.1 44168.5 23517.4 40143.0 True False 38914.694719030995 53285.34173944183 35727.119269858114 37046.18212453749 39040.89509372412 41751.648738653246 46657.55230811997 42997.007900492245 39907.31015706314 45295.74507593258 0.85912472912843 1.1763873549296011 0.7887522152459602 0.817873335838372 0.8619108710603391 0.9217565285362211 1.0300647937218936 0.9492504832057229 0.8810388280436405 1.0 15.467087914453195 -7.015148668177005 24.070975937609678 0.9630095846383956 0.9039412872168584 0.07600510828369322 0.10557052800498513 1410.4308976290067 2241148.5663786447 0.04114325557678717 0.03303121635572642 9.657202359593198e-08 7.015148668177005 -0.059068297421537186 S(ph)PGHMVILDQTK ddPTM_A459_Selumetinib_30min_R2 14 SPGHMVILDQTK 12 0 Q9NWH9;Q9NWH9-3;H7C3F4 Q9NWH9 SLTM SAFB-like transcription modulator 1 S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK;S(1)PGHMVILDQTK 246.63 2.254e-18 412902300.0 1518240.0 1322555.0 1560323.0 1455844.0 1451196.0 1303939.0 1370938.0 1471334.0 1259275.0 1395400.0 True False 1433862.2987962675 1423990.7158154123 1459933.5169312314 1257555.5357290215 1268883.7846231554 1483544.7612702819 1434689.3334621107 1475615.3383475447 1511165.1870833158 1355111.1763153935 1.0581141413762092 1.0508294379855276 1.0773533142135647 0.9280091240545812 0.9363687694417117 1.0947771571806417 1.058724448988085 1.088925664652702 1.1151595629166309 1.0 20.369979787648106 -6.808635972991267 24.999987419217607 1.0762757177157132 1.0115670664992722 0.24393143144843288 0.053677796206789405 185.568411053415 98294.1384378439 0.02031953741422118 0.017920192940495183 1.5536887711551634e-07 6.808635972991267 -0.06470865121644098 S(ph)PGIISQASAPR ddPTM_A459_Selumetinib_30min_R1 2 SPGIISQASAPR 12 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;Q08495-4;E5RFK4;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 S(1)PGIISQASAPR;S(1)PGIISQASAPR 104.09 0.010096 25647000.0 1758.0 2150.16 2087.0299999999997 2243.83 1928.1100000000001 1762.2399999999998 1943.4099999999999 1973.74 1051.95 1583.6 True False 1798.9579795274744 1898.4182676177352 1803.6227892351899 1851.987212405668 1753.7127909354688 1744.5134655858992 1796.8170190516316 1921.3900035889292 1785.0823186118619 1786.870485570257 1.0067646167166726 1.0624263386452875 1.0093752198607648 1.0364417720037666 0.9814437056840153 0.9762954168607021 1.0055664546265088 1.0752821869883546 0.9989992744449946 1.0 10.803219354633603 -11.227647952634518 14.245894015312953 0.9999988929323169 1.0177828250636058 0.0262102337366672 0.030632112374413323 1.116024110907925e-06 2.3146698494645882e-08 0.030732586841884853 0.007453283119343227 5.920413596961919e-12 11.227647952634518 0.017783932131288926 S(ph)PGIISQASAPR ddPTM_A459_Selumetinib_30min_R2 2 SPGIISQASAPR 12 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;Q08495-4;E5RFK4;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 S(0.999)PGIIS(0.001)QASAPR;S(1)PGIISQASAPR 110.25 0.0072971999999999985 17356000.0 22607.2 22125.2 25744.9 33345.0 28843.0 23583.7 24971.3 25476.9 21605.8 27809.0 True False 21350.782327792007 23822.13169626908 24088.50116292773 28803.353476666558 25219.484480308394 26832.140603486794 26132.51492969222 25551.03356107215 25927.563716491397 27006.08191354076 0.7905916302907604 0.8821024750104436 0.8919657890413876 1.06655062251828 0.9338446265936649 0.9935591800909576 0.9676529536329913 0.946121456747154 0.9600638774442658 1.0 14.720996726026126 -5.158447500451469 1.690439295204656 0.9757032002946935 0.7930342929809204 0.6801943876287246 0.04062387755312559 0.2877076532988515 1.3008322410485662 0.011302484270190897 0.0671114888269683 6.943085279040359e-06 5.158447500451469 -0.18266890731377305 S(ph)PGILGYNICPR ddPTM_A459_Selumetinib_30min_R2 3 SPGILGYNICPR 12 0 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(1)PGILGYNICPR;S(1)PGILGYNICPR;S(1)PGILGYNICPR 147.96 0.00061561 19314900.0 5649.6 4012.2 5164.4 6384.8 6468.8 3547.3 2378.8 2938.7 2176.7 3753.0 True False 5335.617849140708 4319.922838743638 4832.128126573567 5515.179225605659 5656.131512194259 4035.9083758167167 2489.418913502777 2947.2511304720256 2612.1008220795734 3644.6411385349534 1.4639624715659885 1.1852807106490955 1.3258172596152913 1.513229702450928 1.551903547482831 1.1073541186661362 0.6830353987892085 0.8086533127529643 0.7166963008955024 1.0 11.83156105445611 -7.019384107314841 4.0860624202376155 0.7915441755102092 1.3952947790982275 0.8386109907917492 0.12503887283025564 0.0852700906846072 3.253846367955615 0.0501790094025879 0.04059172154619309 9.56347865048024e-08 7.019384107314841 0.6037506035880184 S(ph)PGKAEAESDALPDDTVIESEALPSDIAAEAR ddPTM_A459_Selumetinib_30min_R1 4 SPGKAEAESDALPDDTVIESEALPSDIAAEAR 32 1 G3V529;Q9GZR7-2;Q9GZR7;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 S(0.947)PGKAEAES(0.001)DALPDDT(0.052)VIESEALPSDIAAEAR;S(0.977)PGKAEAES(0.003)DALPDDT(0.02)VIESEALPSDIAAEAR;S(0.999)PGKAEAES(0.001)DALPDDTVIESEALPSDIAAEAR;S(0.973)PGKAEAES(0.025)DALPDDT(0.001)VIESEALPSDIAAEAR 146.06 1.1683999999999999e-20 490596000.0 11487.599999999999 19017.2 19539.899999999998 20797.8 15885.7 16449.5 14701.6 12177.6 7516.5 11592.300000000001 True False 11755.238729021508 16790.657383143585 16886.488904987807 17165.854653057766 14448.841239848121 16284.032964951008 13592.646475673933 11854.610489580456 12754.951516560732 13080.284623564101 0.8986990013844557 1.283661469636162 1.2909878791602776 1.3123456520306538 1.1046274340100037 1.2449295587662796 1.0391705430619465 0.906296065471267 0.9751279795229163 1.0 13.67510631339285 -7.434913093184159 3.8925822851341034 0.9567681318408984 1.1993435131344539 0.4447627691295648 0.11623965038750689 0.21005468257356222 5.841974255200799 0.05310796715494973 0.03360533793138716 3.673558048378559e-08 7.434913093184159 0.2425753812935555 S(ph)PGKAEAESDALPDDTVIESEALPSDIAAEAR ddPTM_A459_Selumetinib_30min_R2 5 SPGKAEAESDALPDDTVIESEALPSDIAAEAR 32 1 G3V529;Q9GZR7-2;Q9GZR7;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 S(0.948)PGKAEAES(0.052)DALPDDTVIESEALPSDIAAEAR;S(0.843)PGKAEAES(0.156)DALPDDT(0.001)VIESEALPSDIAAEAR;S(0.895)PGKAEAES(0.104)DALPDDTVIESEALPSDIAAEAR;S(0.979)PGKAEAES(0.021)DALPDDTVIESEALPSDIAAEAR;S(0.967)PGKAEAES(0.033)DALPDDTVIESEALPSDIAAEAR 119.69 5.9902e-17 167342400.0 192870.0 204071.0 185731.0 176686.0 168995.0 129002.0 133174.0 129099.0 108712.0 197393.0 True False 182151.05751978347 219722.589508313 173781.26966862255 152621.06199964962 147764.33726553136 146770.85453643824 139366.85487927485 129474.65671650994 130457.43766707141 191693.75120139372 0.9502190675397411 1.1462167552737395 0.9065567791307276 0.7961712942812921 0.77083544111091 0.7656527853234015 0.7270286798908527 0.6754245034335192 0.6805513317437909 1.0 17.54844378349454 -5.611406846584741 2.5605094544748144 0.7546105598045008 1.048777597857991 0.5546506467068223 0.09749077599913193 0.17882751344313896 2.3556895240290454 0.026658206006817748 0.05535215626399164 2.446770036443732e-06 5.611406846584741 0.2941670380534902 S(ph)PGLCSDSLEK ddPTM_A459_Selumetinib_30min_R1 2 SPGLCSDSLEK 11 0 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 S(1)PGLCSDSLEK;S(1)PGLCSDSLEK 196.02 2.0556e-05 41572000.0 6618.3 6860.7 5637.9 5740.1 6153.5 5234.7 6798.8 6682.6 3163.4 6322.7 True False 6772.493513029968 6057.4460545471 4872.30414676793 4737.699290021874 5596.91701148866 5182.043670727315 6285.961042254717 6505.355739855994 5368.058754405401 7134.280133313383 0.9492889803143475 0.849061985421903 0.6829426453296669 0.6640753098409017 0.7845104070632108 0.7263583114055001 0.8810925453995763 0.9118447297127235 0.7524317315967667 1.0 12.800552150173473 -7.276382442067392 23.69849311175585 0.8789960046619107 0.7704228776356616 0.2403202119201473 0.09540642134660499 669.2303635221147 1061338.631503089 0.041585396390618985 0.028186986879029492 5.2919722470872416e-08 7.276382442067392 -0.1085731270262491 S(ph)PGLCSDSLEK ddPTM_A459_Selumetinib_30min_R2 2 SPGLCSDSLEK 11 0 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 S(1)PGLCSDSLEK;S(1)PGLCSDSLEK 160.56 0.00060085 78263000.0 198741.0 158461.0 168040.0 178774.0 194458.0 164309.0 202476.0 206072.0 156672.0 157121.0 True False 187695.7708432586 170614.44916757775 157228.48934811857 154424.67279764864 170028.44756342302 186941.07330140335 211891.53519858257 206671.6354029441 188010.77778143573 152584.50848061533 1.230110269464897 1.1181636384092883 1.0304354676221488 1.0120599681799747 1.114323133170651 1.2251641740232937 1.388683145546861 1.3544732519762983 1.2321747446944853 1.0 17.21924897086417 -6.814918521540829 3.689829110263556 1.2767324374166584 1.0914489181000788 0.25529663294209026 0.11300579797496721 0.2516764102529621 6.988597781343411 0.040724509590310015 0.036753185690512516 1.5313747376099248e-07 6.814918521540829 -0.1852835193165796 S(ph)PGLLDTTPIR ddPTM_A459_Selumetinib_30min_R1 3 SPGLLDTTPIR 11 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 S(1)PGLLDTTPIR;S(1)PGLLDTTPIR;S(1)PGLLDTTPIR 117.2 0.0056675 46719300.0 1951.75 2962.02 2457.44 2879.81 2375.77 2435.16 2516.59 2094.44 1113.3200000000002 1974.3999999999999 True False 1997.2219775556011 2615.2253213942618 2123.733145751677 2376.9052442288266 2160.882022976262 2410.6645013483726 2326.7615901817667 2038.8886475000743 1889.2227263244047 2227.8334722846157 0.8964862061738729 1.173887255905344 0.9532728420557461 1.06691333701497 0.96994773166789 1.082066739430154 1.0444055263231597 0.9151889819705505 0.8480089512197831 1.0 11.121425681752925 -7.766681332743045 24.159159720635394 0.9111991460731417 1.0310394977044561 0.26372373412641803 0.08015846957916213 97.83706722347056 450895.5127920343 0.038784252077269564 0.01953141587976063 1.7112705137709718e-08 7.766681332743045 0.11984035163131446 S(ph)PGLLDTTPIR ddPTM_A459_Selumetinib_30min_R2 3 SPGLLDTTPIR 11 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 S(1)PGLLDTTPIR;S(1)PGLLDTTPIR;S(1)PGLLDTTPIR 148.78 0.00064275 37848400.0 27401.0 28110.0 32921.9 28773.600000000002 32616.2 25352.4 26985.199999999997 26299.7 23502.4 29233.8 True False 25878.16211489389 30265.946612104028 30803.740796654474 24854.58604277144 28518.66136347242 28844.462973826783 28240.06527015939 26376.22777285029 28203.53671192306 28389.744235465772 0.9115320624328028 1.0660873293213546 1.085030585029823 0.8754776315216658 1.0045409753232506 1.0160170072188588 0.9947277099763584 0.929075921011641 0.9934410284926029 1.0 14.79308223136317 -5.7261398901940455 24.999793304526385 0.974341463004798 1.0254035992575274 0.12074194275767836 0.05838489798064173 370.8551663656156 262644.4269908218 0.01575536445561376 0.027287818470483175 1.8787115692839943e-06 5.7261398901940455 0.051062136252729484 S(ph)PGLPMSDLK ddPTM_A459_Selumetinib_30min_R1 3 SPGLPMSDLK 10 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(1)PGLPMSDLK;S(1)PGLPMSDLK;S(1)PGLPMSDLK 124.39 0.0038579 33197000.0 10975.900000000001 14024.9 7231.4 6935.9 9373.3 8418.9 11818.599999999999 11371.4 5497.200000000001 10764.3 True False 11231.617114616382 12382.858188000884 6249.415599236883 5724.67526796793 8525.48666999052 8334.213509749598 10927.113486790544 11069.793532487125 9328.346900397477 12146.002758161103 0.9247171549561579 1.0195006896141723 0.5145244673222057 0.4713217493814107 0.7019170701457401 0.6861692423171648 0.8996468800773516 0.911393958399124 0.7680178480224372 1.0 13.568193981462858 -7.264267296999388 23.599017045199176 0.8873808538389626 0.7118961360985766 0.21582181577598158 0.1628386028792356 211.95028725244762 1768701.7760063466 0.07344665619744148 0.05206125881255519 5.441676286796545e-08 7.264267296999388 -0.175484717740386 S(ph)PGLPMSDLK ddPTM_A459_Selumetinib_30min_R2 4 SPGLPMSDLK 10 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(1)PGLPMSDLK;S(1)PGLPMSDLK;S(1)PGLPMSDLK;S(1)PGLPMSDLK 134.75 0.002048 41075200.0 149725.0 114851.0 134960.0 142930.0 163711.0 137811.0 183873.0 198659.0 181469.0 132751.0 True False 141403.88389666384 123659.70239582946 126276.82053333767 123462.68743199724 143144.16058509072 156793.21432629804 192423.4588374375 199237.06480023233 217767.87066750473 128918.13370147975 1.0968502245316074 0.9592110810584134 0.97951170178853 0.957682863435527 1.1103493083180407 1.2162231163644153 1.4926019584103616 1.545454150473367 1.6891950295507974 1.0 16.976095682753694 -6.958428830055727 1.9360794168851503 1.4797811499939448 1.0002923780926511 0.5510408528888624 0.17321605259944678 0.22172590025174463 1.6831886259595212 0.072825802291836 0.057973703723015024 1.1004521669570602e-07 6.958428830055727 -0.4794887719012937 S(ph)PGLVPPS(ph)PEFAPR ddPTM_A459_Selumetinib_30min_R2 1 SPGLVPPSPEFAPR 14 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 2 S(1)PGLVPPS(1)PEFAPR 128.82 0.020078 6305800.0 15972.0 12248.0 16716.0 18768.0 17223.0 14004.0 15199.0 14594.0 14639.0 14038.0 True False 15084.34018098189 13187.382216472786 15640.510759004688 16211.766023394166 15059.292764426435 15932.92388434508 15905.783616247143 14636.466123833243 17567.2090478352 13632.686464895718 1.106483320057583 0.9673355468440066 1.1472801636918104 1.1891835160398943 1.1046460140636434 1.1687295769159287 1.1667387537448815 1.0736303634300008 1.2886094822961645 1.0 13.734782268007963 -5.289138109436306 23.240760762185275 1.1471208089662066 1.0369094549273281 0.22350412510022 0.07821169009636592 340.71557462627936 285878.7944702626 0.018755626732150556 0.03906463047934567 5.138802072037598e-06 5.289138109436306 -0.1102113540388785 S(ph)PGLYFLTAGDQGTLR ddPTM_A459_Selumetinib_30min_R2 1 SPGLYFLTAGDQGTLR 16 0 A0A087WYP7;J3KNP2;Q12788 A0A087WYP7 TBL3 Transducin beta-like protein 3 1 S(0.999)PGLY(0.001)FLTAGDQGTLR 96.435 0.014529 0.0 2181.3 2567.4 922.33 2154.4 2038.8 2031.6 2280.5 2057.1 1073.6 3637.5 True False 2060.072078435752 2764.311324507857 862.9882919569744 1860.9670034527048 1782.6677168967433 2311.4344589713987 2386.547768725023 2063.0858204287633 1288.3499988903523 3532.4759236399905 0.5831807839508159 0.7825421557748117 0.2443012523260796 0.5268166135255913 0.5046510593226686 0.6543383476453006 0.6756019914399978 0.5840339368266338 0.36471586126559924 1.0 11.786464012252141 -6.760958582452825 24.99384669579277 0.6309816525613133 0.526563083388373 0.09422651823063333 0.18991982845085906 40.66425154008374 2113941.5090146097 0.06407186184482425 0.060398704599266766 1.7339693540645067e-07 6.760958582452825 -0.10441856917294035 S(ph)PGMEPPFSHR ddPTM_A459_Selumetinib_30min_R1 1 SPGMEPPFSHR 11 0 G3V470;Q99973-2;Q99973 G3V470 TEP1 Telomerase protein component 1 1 S(1)PGMEPPFSHR 108.23 0.005343100000000001 0.0 2785.0 3533.6 2688.8 2401.3 3255.8 2239.4 3017.3 3131.2 1298.5 2871.2 True False 2849.88508133334 3119.884469273929 2323.675728521191 1981.958032983663 2961.3134648581786 2216.873669212514 2789.7026317578348 3048.1504044289795 2203.459661312327 3239.7464878563533 0.8796629896862784 0.9630026549818923 0.7172399869036359 0.6117633093863055 0.9140571572368905 0.6842738089298325 0.8610867060785674 0.9408607790314645 0.6801333590673302 1.0 11.661665210419583 -10.84256904010041 7.283403501578365 1.0000021374182892 0.807309607543616 0.19589273362549908 0.11800879849762193 4.129052003616051e-06 3.856692108179516e-07 0.11518830917328766 0.02793695887347096 1.4369146078690961e-11 10.84256904010041 -0.19269252987467322 S(ph)PGMEPPFSHR ddPTM_A459_Selumetinib_30min_R2 2 SPGMEPPFSHR 11 0 G3V470;Q99973-2;Q99973 G3V470 TEP1 Telomerase protein component 1 1 S(1)PGMEPPFSHR;S(1)PGMEPPFSHR 91.712 0.01722 2268300.0 33404.0 25794.0 33279.0 34507.0 33373.0 29891.0 28826.0 32740.0 30785.0 25420.0 True False 31547.539406806853 27772.316859217757 31137.865371435575 29807.087072104772 29180.38538159456 34008.213926518045 30166.46611763537 32835.26797960123 36942.86020476851 24686.058550908187 1.2779496306285085 1.1250202944283314 1.261354270355566 1.2074461790097386 1.1820593117940663 1.377628342588003 1.222004154912999 1.3301138337611713 1.4965070316342342 1.0 14.591408889461453 -6.741098563908745 24.996314449530207 1.3019299050517237 1.2086283094781742 0.07341194678247376 0.12538649947678443 528.6902529695899 649692.656507023 0.03914910133380924 0.03910576039791099 1.815103675001623e-07 6.741098563908745 -0.09330159557354945 S(ph)PGMLEPLGSSR ddPTM_A459_Selumetinib_30min_R1 4 SPGMLEPLGSSR 12 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR 184.11 0.00010439 440518000.0 3551.49 3148.46 2842.82 2989.55 3433.09 2684.2200000000003 3293.41 3292.96 1431.18 3070.91 True False 3634.2328070034273 2779.8368395206553 2456.7806584924897 2467.4812133037567 3122.567615661268 2657.219183876761 3044.9854321603957 3205.620003758447 2428.6079307485356 3465.09121169649 1.0488130282793122 0.8022405961889997 0.7090089433142693 0.7120970452306481 0.9011501934266474 0.766854036888628 0.8787605422570066 0.92511850566525 0.7008784999802363 1.0 11.758677613627823 -7.29620964324986 23.59503183150967 0.8699492854470682 0.8156812625786309 0.04384760607607108 0.11616720121186867 1201.4328257037218 815283.2921890687 0.048747404821561674 0.03286798997590168 5.055805485271448e-08 7.29620964324986 -0.05426802286843724 S(ph)PGMLEPLGSSR ddPTM_A459_Selumetinib_30min_R2 6 SPGMLEPLGSSR 12 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR;S(1)PGMLEPLGSSR 140.33 0.0010841 371087500.0 75857.8 70453.6 84380.5 72263.5 77497.0 62168.799999999996 81511.3 98674.3 91776.7 79156.0 True False 71641.92715883341 75857.16457597034 78951.5504965421 62421.08663850931 67761.13402802972 70731.98788782286 85301.73696157687 98961.42587659029 110134.60445525357 76870.56060801313 0.9319813279905406 0.9868168512883572 1.027071350489306 0.8120285079851808 0.8814965507219961 0.9201440360049831 1.1096801725768195 1.2873774445489652 1.4327279986530104 1.0 16.230143569457915 -7.487788433782024 2.894308975244534 1.2680333146115659 0.9267973486590109 0.6055217850323344 0.11374891616355427 0.16859479385774503 2.826041112644148 0.057090496813357816 0.032922355665811254 3.2524570198889474e-08 7.487788433782024 -0.341235965952555 S(ph)PGNTSQPPAFFSK ddPTM_A459_Selumetinib_30min_R1 2 SPGNTSQPPAFFSK 14 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5;H7C184 C9J0Q5;Q9Y618;H7C184 NCOR2 Nuclear receptor corepressor 2 1 S(1)PGNTSQPPAFFSK;S(1)PGNTSQPPAFFSK 210.08 4.6745e-06 566650000.0 4451.6 5537.6 3552.0 3974.6000000000004 4595.5 4047.6 5055.2 4568.9 2585.8 4143.1 True False 4555.3136186942575 4889.255217639605 3069.657909739386 3280.5107224823482 4179.837836401425 4006.8848189267546 4673.882194035133 4447.717930121219 4387.913740640285 4674.907242211504 0.9744179686738187 1.0458507440517049 0.6566243458313535 0.7017274466670435 0.8941006997229998 0.8571046678203745 0.9997807340074867 0.9514023914658869 0.9386097976490643 1.0 12.190722024522453 -7.2449847214204715 17.979386252934212 0.968398193036898 0.8494440701722245 0.21730141039412776 0.10881468214936846 37.188083167245914 40633.66635030765 0.04618446832361467 0.03548169140712817 5.6887294357250425e-08 7.2449847214204715 -0.11895412286467355 S(ph)PGNTSQPPAFFSK ddPTM_A459_Selumetinib_30min_R2 4 SPGNTSQPPAFFSK 14 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5;H7C184 C9J0Q5;Q9Y618;H7C184 NCOR2 Nuclear receptor corepressor 2 1 S(1)PGNTSQPPAFFSK;S(1)PGNTSQPPAFFSK;S(1)PGNTSQPPAFFSK;S(1)PGNTSQPPAFFSK 197.75 0.00010148 529119000.0 585672.0 544603.0 637896.0 683163.0 718907.0 504527.0 546787.0 572759.0 495055.0 544440.0 True False 553122.6948707764 586372.2989253545 596854.4658486516 590115.0208780931 628591.4755498767 574021.0146098945 572213.6789378863 574425.6338646435 594079.8329924222 528720.6025749979 1.0461530951828515 1.1090400034906505 1.128865534919247 1.1161188310122385 1.1888915856285593 1.0856793017224458 1.082260982740348 1.0864445816316803 1.1236177105622684 1.0 19.012146019528394 -10.677098828394046 6.270680783178203 0.9999994617575517 1.1087798735828225 0.44859838339983726 0.03571172944462698 2.7969102498583485e-07 3.771363259667196e-08 0.03582507143445112 0.008688812978001725 2.1032997567560777e-11 10.677098828394046 0.10878041182527076 S(ph)PGPAADGPIDLSK ddPTM_A459_Selumetinib_30min_R1 2 SPGPAADGPIDLSK 14 0 Q8IX07 Q8IX07 ZFPM1 Zinc finger protein ZFPM1 1 S(1)PGPAADGPIDLSK;S(1)PGPAADGPIDLSK 217.39 1.1915e-08 20542000.0 2419.26 3067.7 2352.92 2946.3999999999996 2729.1 2323.94 2703.7 2773.52 1353.57 2312.58 True False 2475.6240509394984 2708.53225786496 2033.406387664415 2431.866550777937 2482.2533868617397 2300.563273568695 2499.7577322386423 2699.95723993736 2296.909429158665 2609.4221694367684 0.9487250012418842 1.0379816227473777 0.7792554273053165 0.9319559629949967 0.9512655391432973 0.8816370537946571 0.9579736700015097 1.0346954477358998 0.8802368034048097 1.0 11.34951465636869 -7.5081473410224415 24.151321660722672 0.9737465804433761 0.9221887909144834 0.09533724133092247 0.07090520430898185 1066.097016018928 1747819.7186842842 0.030495904545632203 0.019710774203655065 3.103506497617424e-08 7.5081473410224415 -0.05155778952889278 S(ph)PGPGPDLYSAPIFSSNYSSR ddPTM_A459_Selumetinib_30min_R1 3 SPGPGPDLYSAPIFSSNYSSR 21 0 Q8NEA6-2;Q8NEA6 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 S(1)PGPGPDLYSAPIFSSNYSSR;S(1)PGPGPDLYSAPIFSSNYSSR;S(0.999)PGPGPDLYSAPIFSSNYSSR 164.69 1.2372000000000002e-08 26113300.0 487.08 408.97 510.82500000000005 697.1 683.9200000000001 509.3330000000001 555.28 452.923 251.714 302.81 True False 498.428016307305 361.0876022750051 441.4577707608737 575.3645711876529 622.0595567558832 504.2095724573625 513.3947825415075 440.9100107387538 427.14027353682764 341.6786131191778 1.4587627002965295 1.0568048113361355 1.2920263481837913 1.6839349877218253 1.8205984596961249 1.4756837364049291 1.502566338158353 1.290423204173344 1.2501229434218077 1.0 8.416496136949174 -8.403689096554597 1.3646603585769856 1.0118184234215557 1.467421702140094 0.3566729769640846 0.19618537637469846 0.5303196025740813 2.0982636222051174 0.21198567959106637 0.06482940126449448 3.947397879162522e-09 8.403689096554597 0.45560327871853823 S(ph)PGPGPDLYSAPIFSSNYSSR ddPTM_A459_Selumetinib_30min_R2 2 SPGPGPDLYSAPIFSSNYSSR 21 0 Q8NEA6-2;Q8NEA6 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 S(1)PGPGPDLYSAPIFSSNYSSR;S(1)PGPGPDLYSAPIFSSNYSSR 279.27 7.7613e-73 20707000.0 4786.3 3104.7 7913.299999999999 6984.9 7198.2 3842.1 4278.700000000001 3479.4 5816.8 4396.5 True False 4520.296607076989 3342.820506816055 7404.166893349587 6033.5445703754185 6293.897763275524 4371.314399888762 4477.668028083206 3489.5244779543214 6980.3225349715 4269.561621521163 1.058726166239637 0.7829423259676651 1.7341749691650132 1.413153177123084 1.474132082214363 1.0238321372046029 1.048741867435069 0.8173027554784583 1.6349038036566725 1.0 12.059872232979831 -6.78279223515678 24.9754198588047 1.0900241218744529 1.295536550548503 0.08441738210661887 0.30698967041407926 635.5835950028496 743406.7434875688 0.11195932919054462 0.09882898368410496 1.6489510548331727e-07 6.78279223515678 0.20551242867405017 S(ph)PGPGPGPGAGAEPGATGGSSHFISSR ddPTM_A459_Selumetinib_30min_R1 2 SPGPGPGPGAGAEPGATGGSSHFISSR 27 0 Q9ULI0-2;Q9ULI0;C9JG15 Q9ULI0-2 ATAD2B ATPase family AAA domain-containing protein 2B 1 S(1)PGPGPGPGAGAEPGATGGSSHFISSR;S(1)PGPGPGPGAGAEPGATGGSSHFISSR 83.695 4.913e-05 15818100.0 2046.5299999999997 2056.59 2022.7800000000002 2360.5 3059.1000000000004 2157.9 2724.8 2156.0 1059.29 1544.51 True False 2094.2101671458263 1815.803486717249 1748.0975863352014 1948.2829870728087 2782.40494512797 2136.1934852164363 2519.2661422509364 2098.815876325012 1797.537762519471 1742.7629033014134 1.2016609736061323 1.0419107976635666 1.003061049224586 1.1179277361149167 1.596548182117662 1.225751065259494 1.4455587374958174 1.2043037365261262 1.0314298973855218 1.0 10.767160593943178 -4.370296487237422 19.256276606737583 1.2010647713477294 1.7222167372949089 0.0 0.18906469590549185 581491.2669965993 17304973.15806562 0.04837978414158104 10256492.10816693 4.262883978534682e-05 4.370296487237422 0.5211519659471795 S(ph)PGPGPSQSPR ddPTM_A459_Selumetinib_30min_R2 2 SPGPGPSQSPR 11 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 S(1)PGPGPSQSPR;S(1)PGPGPSQSPR 130.44 0.0023944 2775100.0 4775.9 1988.43 5272.799999999999 6613.4 7142.0 3314.8999999999996 1643.24 4437.3 6227.9 3721.4 True False 4510.474597442487 2140.936187189824 4933.553788590566 5712.643511248661 6244.758109709903 3771.497385333866 1719.6539160182867 4450.211808365441 7473.654022065221 3613.953512641611 1.248072113176012 0.59240833610638 1.3651403570447138 1.5807185928833427 1.7279575091006945 1.043593220593781 0.47583730947366554 1.2313970815613977 2.067999490287403 1.0 11.81936223316876 -5.292539446847217 23.985044274211887 1.3049084221814093 0.9202399308305276 0.11356013685652333 0.4370289360012714 851.7870118259597 656915.2277023485 0.12149363822930301 0.2529641666615852 5.098712840044087e-06 5.292539446847217 -0.38466849135088177 S(ph)PGPLPGAR ddPTM_A459_Selumetinib_30min_R2 1 SPGPLPGAR 9 0 Q96A47 Q96A47 ISL2 Insulin gene enhancer protein ISL-2 1 S(1)PGPLPGAR 87.806 0.032032 11856000.0 8188.5 8523.6 12662.0 13827.0 13048.0 9023.6 9965.1 9568.9 3534.9 9111.8 True False 7733.415951162675 9177.332712306292 11847.340705343222 11943.738747094572 11408.793589399987 10266.518991914894 10428.496895471044 9596.743914783334 4241.978773358333 8848.718658700449 0.8739588464097953 1.037136908323188 1.338876413896875 1.3497704252751852 1.2893158918757532 1.1602266257861416 1.178531864070205 1.0845348671298747 0.4793890434280485 1.0 13.11125284510354 -8.083600557384079 6.289172817395349 0.743141519896675 1.1833863536398268 0.48179263710035913 0.17796696201968984 0.2011395169691462 12.236960196757032 0.12476677336689392 0.04645544008936861 8.248964652425055e-09 8.083600557384079 0.4402448337431518 S(ph)PGPPALK ddPTM_A459_Selumetinib_30min_R1 1 SPGPPALK 8 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 S(1)PGPPALK 93.598 0.023839 48013000.0 7103.9 9203.3 6678.8 6974.7 7995.5 7502.3 7582.8 7542.5 4190.9 7378.9 True False 7269.40704821685 8125.773357501907 5771.855644022359 5756.699576334131 7272.308436720176 7426.833673543387 7010.823291052699 7342.448398507143 7111.651208774608 8326.0536915726 0.873091541023179 0.9759453468005603 0.6932282516823631 0.6914079334079843 0.8734400120528893 0.8919992530267515 0.8420343599451993 0.88186416644646 0.8541442887850726 1.0 13.023417146565125 -6.489986015355648 24.89456673407927 0.8833035971129 0.8084400433289773 0.17477400655453845 0.08686614217880069 1322.5953904461924 1000995.1914487163 0.028841432722853107 0.032678643976274846 3.236040770829018e-07 6.489986015355648 -0.07486355378392262 S(ph)PGPPALK ddPTM_A459_Selumetinib_30min_R2 1 SPGPPALK 8 0 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 S(1)PGPPALK 83.99799999999998 0.037547 11737000.0 48347.0 43417.0 52652.0 59175.0 50072.0 42850.0 41747.0 40591.0 38148.0 46961.0 True False 45660.06728837537 46746.9442923415 49264.42764316314 51115.26291743124 43781.507710640464 48752.19854642865 43688.31822011117 40709.113089798215 45778.66594417768 45605.11391066877 1.0012049827967593 1.0250373320831814 1.0802391095801718 1.1208230510629957 0.9600131203794298 1.0690072749719337 0.9579697203626721 0.8926436006615216 1.0038055388667346 1.0 15.476907989024815 -7.2748077198475425 21.958903058492 0.9546582881083758 1.0434130511708943 0.36651614212117833 0.05040474157507396 160.07672681517184 262938.9194623055 0.021066551855203133 0.01433154290918346 5.311195407994753e-08 7.2748077198475425 0.0887547630625185 S(ph)PGPPALKHPATK ddPTM_A459_Selumetinib_30min_R1 1 SPGPPALKHPATK 13 1 Q8IU81 Q8IU81 IRF2BP1 Interferon regulatory factor 2-binding protein 1 1 S(1)PGPPALKHPATK 71.697 0.031395 42588000.0 2349.3 2121.9 4716.1 4871.3 4850.4 3305.4 2619.8 3061.8 2075.1 2352.9 True False 2404.0341190579597 1873.466961555452 4075.679523682974 4020.6189006260447 4411.682176407675 3272.150677063075 2422.1863767869186 2980.5911178719475 3521.2931406924986 2654.9176341868274 0.9055023357793506 0.7056591652528892 1.535143490404858 1.5144043825892612 1.6617020880796272 1.2324867012551595 0.9123395564506122 1.1226680178290618 1.326328581854869 1.0 11.374451388405848 -7.018624009434274 24.10717157265061 1.096535881388657 1.2808314741216833 0.0752481636614305 0.2885694912900898 1505.0311271514306 1948129.0990022356 0.12254294954581126 0.09675350380847729 9.580231211454672e-08 7.018624009434274 0.18429559273302631 S(ph)PGPPPPVGVK ddPTM_A459_Selumetinib_30min_R1 2 SPGPPPPVGVK 11 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 S(1)PGPPPPVGVK;S(1)PGPPPPVGVK 155.33 0.00053291 17803400.0 6942.5 7382.4 5688.2 5940.4 7098.9 5522.799999999999 7752.8 7151.2 3475.8 5882.799999999999 True False 7104.246742246579 6518.065176015354 4915.773683046051 4903.020655118537 6456.805748412589 5467.245646301187 7168.000054184913 6961.526945628675 5898.178737612159 6637.914683324522 1.070252794916686 0.9819447050727771 0.740559937504958 0.7386386973962908 0.9727159893502538 0.8236390353186914 1.0798572136204232 1.0487520972689084 0.8885589856147601 1.0 12.696514371334157 -7.257930031303678 24.772432949311266 1.0083547482232704 0.8825960373871119 0.21353904256206535 0.10897068667545796 438.2114778121208 3093341.1374881906 0.045715704131062705 0.03396805892152273 5.5216639102235254e-08 7.257930031303678 -0.12575871083615853 S(ph)PGPSSPR ddPTM_A459_Selumetinib_30min_R1 1 SPGPSSPR 8 0 A0A087WX15;A0A1B0GWJ3;Q9C0E4 A0A087WX15 GRIP2 Glutamate receptor-interacting protein 2 1 S(0.991)PGPS(0.009)SPR 86.67 0.033547 3473400.0 1193.1 1514.2 1129.9 1215.5 1414.5 1127.0 1304.0 1126.8 742.06 1038.0 True False 1220.8969086315294 1336.9167600675182 976.4657860964336 1003.2357427608548 1286.5587247502576 1115.6634032341274 1205.6382301435767 1096.913603637766 1259.2216220819596 1171.2374109762113 1.0423991730369402 1.1414566744014907 0.8337044026646672 0.8565605344903308 1.0984610914006985 0.9525510308830012 1.0293713459329248 0.9365424920328516 1.0751207315282172 1.0 10.19381782584875 -6.289900938843701 24.99929715783996 1.0097302237036958 0.9712515816911332 0.05455031559689738 0.0934668215618037 3185.2027272236332 2797721.838452869 0.03078497206233155 0.03491352460693035 5.12978379344665e-07 6.289900938843701 -0.03847864201256257 S(ph)PGQMTVPLCIGVSTDK ddPTM_A459_Selumetinib_30min_R2 3 SPGQMTVPLCIGVSTDK 17 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 S(0.84)PGQMT(0.16)VPLCIGVSTDK;S(1)PGQMTVPLCIGVSTDK;S(0.506)PGQMT(0.494)VPLCIGVSTDK 182.98 6.7373e-08 13659800.0 30081.1 33461.9 35366.8 41550.6 36930.0 29786.600000000002 38657.6 37157.2 31291.2 32286.1 True False 28409.31288618424 36028.3201330332 33091.33859246035 35891.33660121706 32290.523241611103 33889.433774166864 40455.254998581215 37265.32130029441 37550.31434917826 31353.916403637988 0.9060849853796228 1.1490851627343384 1.0554132430046528 1.144716217877413 1.0298720844284843 1.0808676446631937 1.2902775678092706 1.1885380065620932 1.1976275584131273 1.0 14.936358040223062 -7.03819041606798 21.954279498854483 1.1849296829056282 1.065773464006445 0.24084508497216794 0.09248830817565273 169.82514057352913 97625.08892358409 0.033284457026566065 0.025794839873776076 9.158188620346413e-08 7.03819041606798 -0.11915621889918326 S(ph)PGRGDCSTNSPVGVSK ddPTM_A459_Selumetinib_30min_R2 2 SPGRGDCSTNSPVGVSK 17 1 Q96L73-2;Q96L73-3;Q96L73 Q96L73-2 NSD1 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 1 S(0.989)PGRGDCS(0.005)T(0.005)NSPVGVSK;S(0.996)PGRGDCS(0.004)TNSPVGVSK 106.0 0.0014278 11900800.0 40957.0 36468.0 46128.0 45558.0 47119.0 31346.0 37794.0 39514.0 31143.3 42776.0 True False 38680.7739038615 39264.978336898246 43160.17470036897 39352.92180806646 41199.48997079538 35663.6269693431 39551.49588739026 39628.97919810517 37372.83021650697 41540.9457346046 0.9311481291491034 0.9452114688903095 1.0389791069300456 0.947328499921092 0.991780260228289 0.8585174540124746 0.9521087011373196 0.953973928549568 0.8996624789255704 1.0 15.34224644096775 S(ph)PGSGSQSSGWHEVEPGMPSPTTLK ddPTM_A459_Selumetinib_30min_R1 1 SPGSGSQSSGWHEVEPGMPSPTTLK 25 0 A0A590UJA3;S4R3W2;A0A590UJU2;A0A590UK38;B1AKN5;A0A590UK09;B1AKN8;Q12857-2;Q12857-3;Q12857;Q12857-4 A0A590UJA3 NFIA Nuclear factor 1;Nuclear factor 1 A-type 1 S(0.885)PGS(0.041)GS(0.049)QS(0.012)S(0.012)GWHEVEPGMPSPTTLK 119.69 5.1211e-08 8030900.0 1004.4 1372.1 1240.8 1670.4 2268.5 1567.8 1982.3 1180.7 364.45 783.21 True False 1027.8005657778126 1211.4538941280157 1072.3061752265291 1378.695997291429 2063.3145755362034 1552.0293554485052 1832.7735150411133 1149.384000545892 618.4450316251651 883.7426326114432 1.16300892120671 1.370822057716274 1.213369295150879 1.5600650533486289 2.334745998887874 1.7562006156275238 2.0738769947369193 1.3005867977077028 0.6998021921808518 1.0 9.787482472608513 -5.809168853793133 6.382036113844823 1.6120620971629132 1.2612924000822368 0.056269989565564726 0.4566929404503322 0.47630420215063374 45.0826185686438 0.13659328108959978 0.20735457259522438 1.5517835588548409e-06 5.809168853793133 -0.3507696970806764 S(ph)PGSISYLPSFFTK ddPTM_A459_Selumetinib_30min_R1 1 SPGSISYLPSFFTK 14 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 S(1)PGSISYLPSFFTK 155.43 0.00032841 2952200.0 430.51 594.04 700.87 626.47 479.54 434.9 427.21 558.68 329.23 490.52 True False 440.54004537336334 524.4895206382964 605.6957036033346 517.0687747983487 436.16569166966354 430.5253008576059 394.9852057512559 543.8619915516036 558.6792639921891 553.4830200694131 0.7959413918752459 0.9476162802113052 1.0943347521797027 0.934208920688303 0.7880380713666038 0.7778473507707844 0.7136356336671723 0.9826173014004966 1.0093882625742057 1.0 9.11239524799671 -7.969432829607686 24.99847031469847 1.0017973037406107 0.8711844465841111 0.2593601654321166 0.10284896707004905 311.28449405585866 254574.79966999197 0.06415857589434315 0.030820203875218888 1.072919578693648e-08 7.969432829607686 -0.13061285715649962 S(ph)PGSISYLPSFFTK ddPTM_A459_Selumetinib_30min_R2 2 SPGSISYLPSFFTK 14 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 S(1)PGSISYLPSFFTK;S(1)PGSISYLPSFFTK 219.84 8.537399999999999e-09 236210000.0 449980.0 436750.0 538360.0 558540.0 526510.0 443220.0 479760.0 440650.0 356410.0 494910.0 True False 424971.9130126622 470247.3206274071 503722.50372204813 482465.8884647582 460365.10674087936 504269.53184943006 502069.7906264047 441932.218546465 427701.95892744954 480620.66236939374 0.8842148211390021 0.9784167794808332 1.048066683689306 1.0038392566941832 0.9578554206790502 1.049204853914209 1.0446279778136665 0.9195031615324234 0.8898950719657739 1.0 18.87453914715985 -7.783126796840579 24.85519495963875 0.9285242878532979 0.9975407885818667 0.19496244104810068 0.05380030539384578 337.3862804058543 386660.70467118436 0.029929996251776343 0.014398424969396072 1.6476812634235708e-08 7.783126796840579 0.0690165007285688 S(ph)PGSNSKVPEIEVTVEGPNNNNPQTSAVR ddPTM_A459_Selumetinib_30min_R1 2 SPGSNSKVPEIEVTVEGPNNNNPQTSAVR 29 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 S(0.347)PGS(0.347)NS(0.305)KVPEIEVTVEGPNNNNPQTSAVR;S(0.568)PGS(0.252)NS(0.066)KVPEIEVT(0.113)VEGPNNNNPQT(0.001)SAVR 68.153 0.00025814 99008000.0 3370.5 1662.52 9649.900000000001 8554.6 5802.0 3762.6 3386.9 3560.5 2540.8 2038.2 True False 3449.0260921486656 1467.8713855154201 8339.496583106455 7060.69969973016 5277.2101244262985 3724.7516601674606 3131.423406191166 3466.0639738660498 4311.55202731025 2299.8228237492413 1.4996920878130768 0.6382541169508229 3.626147413178183 3.07010593460395 2.294615946033282 1.619582005058658 1.3615933253006962 1.507100433161006 1.8747322544966427 1.0 11.167307006203863 -6.817986725257486 4.784395732545068 1.4832910892782414 2.2634571168017095 0.18827983699817974 0.7835929496540008 0.40406633446711615 18.899121040263946 0.30761198308834803 0.27562899179118605 1.520594007839561e-07 6.817986725257486 0.7801660275234681 S(ph)PGSNSKVPEIEVTVEGPNNNNPQTSAVR ddPTM_A459_Selumetinib_30min_R2 1 SPGSNSKVPEIEVTVEGPNNNNPQTSAVR 29 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 S(0.409)PGS(0.409)NS(0.162)KVPEIEVT(0.021)VEGPNNNNPQTSAVR 60.343 0.0018857 18987000.0 29075.0 50101.0 42127.0 60503.0 47008.0 24814.0 13997.0 6709.9 7452.3 41473.0 True False 27459.12789644683 53943.58559989406 39416.59468440958 52262.387026503435 41102.434783148004 28231.90326093536 14647.888234529326 6729.4246981162605 8942.968234659618 40275.566730205195 0.6817812913816429 1.339362546062905 0.9786726267180887 1.2976201521034976 1.0205302648745271 0.7009684916429114 0.36369167273675995 0.16708454391703045 0.22204450391886654 1.0 15.29761726924117 -6.953387596363534 2.4426318652730155 0.37024739936348844 1.0929609165551761 0.5330146519459762 0.27357141637463384 0.197500221654988 2.3850429546344944 0.10680717198109382 0.08756856826765275 1.1133004987690032e-07 6.953387596363534 0.7227135171916876 S(ph)PGSPPGPELPIETALDDR ddPTM_A459_Selumetinib_30min_R1 2 SPGSPPGPELPIETALDDR 19 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.943)PGS(0.057)PPGPELPIETALDDR;S(0.94)PGS(0.06)PPGPELPIETALDDR 140.12 8.1196e-05 13516800.0 3607.5 4757.1 3567.7 3982.8999999999996 4423.1 3107.8900000000003 4024.5 4273.0 2221.18 3896.8999999999996 True False 3691.547731026939 4200.13652048421 3083.225935973312 3287.3612832926437 4023.0313859617295 3076.6274483383436 3720.928724856462 4159.666159339879 3769.18023143143 4397.105074020421 0.839540486043385 0.9552049472959 0.7011945095854203 0.7476194514239567 0.9149272801623857 0.6996938659747058 0.8462223809116964 0.9460010823749901 0.8571958522667601 1.0 12.102338292526944 -8.2946746981461 0.9253187872733308 0.9873149151840723 0.812461351816665 0.29359127442952104 0.08504503317998209 0.7039063807790008 1.2821590831563936 0.08180241519028039 0.02915022680726775 5.073706044210598e-09 8.2946746981461 -0.17485356336740732 S(ph)PGSPPGPELPIETALDDRER ddPTM_A459_Selumetinib_30min_R1 2 SPGSPPGPELPIETALDDRER 21 1 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.834)PGS(0.165)PPGPELPIET(0.001)ALDDRER;S(0.71)PGS(0.29)PPGPELPIETALDDRER 101.33 0.00013518 40583100.0 1152.71 1161.4299999999998 1584.07 1575.01 1628.27 1369.83 1362.43 1098.61 635.73 853.2 True False 1179.5659002167881 1025.4492356658411 1368.961994673669 1299.964070099362 1480.9932659944163 1356.0507539061264 1259.660808201314 1069.4712940117915 1078.7873781178941 962.7165308717753 1.2252473728155968 1.0651621768011599 1.421978277898712 1.3503082458989217 1.5383482245322229 1.4085670188691706 1.3084441450908137 1.110889093223886 1.1205659646677226 1.0 9.910967252944078 -7.77575708489228 3.464858928534436 1.0753297057992268 1.3386446579756834 0.48239394847660066 0.12134597604662373 0.23604848469096348 5.907162743677842 0.07909042391375874 0.03728922926496404 1.675879988411882e-08 7.77575708489228 0.2633149521764566 S(ph)PGSPPGPELPIETALDDRER ddPTM_A459_Selumetinib_30min_R2 2 SPGSPPGPELPIETALDDRER 21 1 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.819)PGS(0.181)PPGPELPIETALDDRER;S(0.5)PGS(0.5)PPGPELPIET(0.001)ALDDRER 93.388 0.00028596 9617000.0 17300.7 19616.1 20236.3 20133.1 19349.9 14403.3 9853.0 13552.5 10070.099999999999 19478.6 True False 16339.196354189418 21120.591794297183 18934.31848961752 17390.937048465305 16918.992571699186 16387.22383486056 10311.184023349102 13591.935531262854 12084.401382102953 18916.202206519298 0.8637672708192061 1.1165344694305583 1.0009577124890312 0.9193672629737314 0.8944180436952724 0.8663062308148118 0.5450980017434708 0.7185340578870804 0.6388386659314824 1.0 14.207334848364308 -6.822016108923544 1.9642021480769292 0.7042265634009899 0.9813476502980917 0.4126041793671189 0.12778719466265373 0.2783620491829378 2.2089787112975174 0.050846812202823465 0.04471162473564955 1.5065511839019187e-07 6.822016108923544 0.2771210868971018 S(ph)PGSPVGEGTGSPPK ddPTM_A459_Selumetinib_30min_R2 1 SPGSPVGEGTGSPPK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.991)PGS(0.009)PVGEGTGSPPK 159.41 0.00010012 0.0 13798.0 11019.0 13275.0 17854.0 14338.0 13064.0 12258.0 15953.0 10145.0 12726.0 True False 13031.16239777037 11864.121868330632 12420.900952727156 15422.254400132097 12536.732256653666 14863.447416815487 12828.021288766206 15999.42058883867 12174.283474983811 12358.567313881109 1.0544233863688879 0.9599916856871332 1.0050437593017787 1.2478998583282273 1.0144163104223611 1.2026836962016547 1.037986116267523 1.2946015652532932 0.9850885758666936 1.0 13.593223885820844 -5.58133151916755 24.998746376220765 1.1211794823172916 1.0010338623802533 0.17199973541259017 0.1043244093086724 104.85753214044325 44844.13621813463 0.025807014039331833 0.04469906990959581 2.6222161076684222e-06 5.58133151916755 -0.12014561993703832 S(ph)PGSPVGEGTGSPPKWQIGEQEFEALMR ddPTM_A459_Selumetinib_30min_R1 1 SPGSPVGEGTGSPPKWQIGEQEFEALMR 28 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.531)PGS(0.453)PVGEGT(0.013)GS(0.004)PPKWQIGEQEFEALMR 72.469 0.00014992 25276000.0 479.79 375.53 817.37 917.92 548.0 490.22 421.83 483.57 304.12 220.82 True False 490.9681734911759 331.5627730208393 706.3756434920276 757.6225034924263 498.43349675725824 485.2888318841472 390.01102348271854 470.744152743268 516.0694279540272 249.1643979689469 1.9704587713705581 1.3306988306658547 2.834978228230112 3.0406531176530605 2.0004202077833666 1.9476652195897917 1.5652758847647457 1.8892913938769709 2.0712005092250156 1.0 7.960954132362236 -6.77222386713536 2.76837889533821 1.71845168242006 2.278837332361504 0.2312846043472634 0.5131751849794426 0.48696915716660155 7.657097597845808 0.20572251003736158 0.18970708477432044 1.689569779314459e-07 6.77222386713536 0.5603856499414439 S(ph)PGSQAPDEGAGGALR ddPTM_A459_Selumetinib_30min_R2 2 SPGSQAPDEGAGGALR 16 0 P10075 P10075 GLI4 Zinc finger protein GLI4 1 S(1)PGSQAPDEGAGGALR;S(0.999)PGS(0.001)QAPDEGAGGALR 123.76 0.0013412 47952000.0 1928.0 0.0 5688.5 4529.6 1922.7 2306.9 2307.1 2498.5 3045.0 1982.7 True False 1820.8494783955102 0.0 5322.508103170505 3912.660666004168 1681.1532368439118 2624.65453504682 2414.384721431921 2505.7702213510574 3654.0850844086444 1925.4542993267385 0.945672654517012 0.0 2.76428690363183 2.0320714271807354 0.8731203007164335 1.3631352018921283 1.253929902296899 1.301391688302981 1.8977781428966376 1.0 10.910983165824966 -5.2316414497060535 24.998761950070342 1.5457427492631204 0.47283631157059675 0.3700154899662196 0.567530468223881 770.3983539478357 646317.9020386243 0.1476101699018634 0.3904241017264835 5.8662227563468725e-06 5.2316414497060535 -1.0729064376925237 S(ph)PGSSWQEYGPSDTCGSR ddPTM_A459_Selumetinib_30min_R1 2 SPGSSWQEYGPSDTCGSR 18 0 Q5JSZ5;A0A494C0D3 Q5JSZ5 PRRC2B Protein PRRC2B 1 S(0.993)PGS(0.003)S(0.004)WQEYGPSDTCGSR;S(0.999)PGS(0.001)SWQEYGPSDTCGSR 145.17 0.00027625 5529200.0 1020.1800000000001 1106.21 951.06 1185.08 1168.58 827.23 1200.47 1065.87 353.92 395.49 True False 1043.9482090752779 976.6944189369236 821.9112757986319 978.128024706733 1062.882145329556 818.9088172647448 1109.9175813960578 1037.599665166299 600.5763907059365 446.254993898826 2.3393535609642044 2.188646474079252 1.8417973737790234 2.1918590000776375 2.3817820749598835 1.8350692506769035 2.4871824328484626 2.3251272912399976 1.3458143862074023 1.0 8.801724503751775 -8.394539580688404 3.785813890022682 1.018236432473931 2.189188674761832 0.8022170608958026 0.20650695200273755 0.09366408774144512 2.226871783652054 0.20014088739141758 0.05295852418597769 4.03144203051824e-09 8.394539580688404 1.1709522422879008 up S(ph)PGSSWQEYGPSDTCGSR ddPTM_A459_Selumetinib_30min_R2 2 SPGSSWQEYGPSDTCGSR 18 0 Q5JSZ5;A0A494C0D3 Q5JSZ5 PRRC2B Protein PRRC2B 1 S(0.999)PGS(0.001)SWQEYGPSDTCGSR;S(0.974)PGS(0.011)S(0.015)WQEYGPSDTCGSR 264.01 5.301e-43 10823200.0 12128.0 11731.3 15607.1 17928.5 15532.1 14823.7 10631.599999999999 10816.099999999999 13861.8 13724.3 True False 11453.974312230688 12631.052987925146 14602.956177725651 15486.607371612434 13580.818739264236 16865.53011884934 11125.99046611574 10847.573060298257 16634.547331052792 13328.043798986202 0.8593890059921573 0.9477049429328802 1.0956563767322272 1.1619565185395342 1.0189656444779436 1.26541676882336 0.8347804549503385 0.8138908622976897 1.2480861844345155 1.0 13.702177426397688 -5.014971826841422 3.6527481464796563 1.0499650774324711 0.8681216557999439 0.1622064051482206 0.14359845570116744 0.4311967223761309 12.17964593611379 0.03797876499917248 0.15533609432012657 9.661135498008646e-06 5.014971826841422 -0.1818434216325272 S(ph)PGSTPTTPT(ph)SSQAPQK ddPTM_A459_Selumetinib_30min_R1 1 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 2 S(0.574)PGS(0.4)T(0.026)PT(0.002)T(0.101)PT(0.72)S(0.146)S(0.03)QAPQK 161.2 0.0037866 10148000.0 1543.1 2487.1 1759.3 1337.6 1477.2 1578.9 2251.6 1868.0 902.01 1432.7 True False 1579.0512276500829 2195.9091757785795 1520.3967231431604 1104.013269861719 1343.587520820843 1563.017699526499 2081.7599992264413 1818.4545718808538 1530.6450897961731 1616.6010006797856 0.9767723928081741 1.3583495091585327 0.9404897822677514 0.6829225451409953 0.8311188229228242 0.9668543436934935 1.2877389030138267 1.1248629507937877 0.9468292356323745 1.0 10.658747930466873 -10.809472874643328 16.26974097722433 0.9999957772679419 1.0158868252212088 0.00018783693308910276 0.1903817880913867 0.0 0.0 0.20261212781220928 0.04914065905887557 1.5506976379279752e-11 10.809472874643328 0.0158910479532669 S(ph)PGSTPTTPT(ph)SSQAPQK ddPTM_A459_Selumetinib_30min_R2 1 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 2 S(0.991)PGS(0.007)T(0.004)PT(0.004)T(0.043)PT(0.77)S(0.152)S(0.03)QAPQK 155.24 0.0025901999999999995 0.0 10944.0 11390.0 9199.3 11552.0 11285.0 9535.7 9063.8 8765.1 9202.7 13029.0 True False 10335.776292303146 12263.576375377617 8607.427053440528 9978.597671688472 9867.277410819963 10849.156118533936 9485.284659578978 8790.604989859587 11043.497144921987 12652.818916592567 0.8168753825085638 0.9692366939113854 0.6802774235670898 0.7886462089963848 0.7798481489275311 0.8574497264247293 0.7496578210836662 0.694754666751124 0.8728092307114141 1.0 13.627171217744182 -8.532119979672633 22.39926928419511 1.0000000059493641 0.7938411828248559 0.40727551634821435 0.07760801103872086 301.2819349453928 730261.3406255672 0.07587107586511024 0.01958982755830521 2.9368381989565723e-09 8.532119979672633 -0.20615882312450817 S(ph)PGSTPTTPTSSQAPQK ddPTM_A459_Selumetinib_30min_R1 3 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 S(0.959)PGS(0.041)TPTTPTSSQAPQK;S(0.926)PGS(0.069)T(0.004)PT(0.001)TPTSSQAPQK;S(0.88)PGS(0.111)T(0.008)PTTPTSSQAPQK 284.53 3.7178999999999994e-64 83668800.0 8447.9 11512.9 9182.099999999999 9743.0 9594.099999999999 8635.7 10150.2 9068.5 4415.97 8123.2 True False 8644.719633248093 10164.964315797995 7935.221253664983 8041.567948761019 8726.315348975926 8548.832698588243 9384.562242027101 8827.973921360566 7493.578560312204 9165.891846668552 0.9431400433106916 1.1089989371293496 0.8657336772470352 0.8773361155994677 0.9520421465749245 0.9326787661907023 1.0238569687507308 0.9631331101260151 0.8175504016050364 1.0 13.16205954733313 -5.268210859443712 24.99789434926166 0.9302157396228175 1.0260694910320705 0.2364490265349941 0.0697185762858338 696.711635579393 2572018.4483606117 0.018127356661246603 0.03906602111736571 5.3924874191970985e-06 5.268210859443712 0.09585375140925301 S(ph)PGSTPTTPTSSQAPQK ddPTM_A459_Selumetinib_30min_R2 4 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 S(1)PGSTPTTPTSSQAPQK;S(0.99)PGS(0.01)TPTTPTSSQAPQK;S(0.951)PGS(0.038)T(0.011)PTTPTSSQAPQK;S(0.951)PGS(0.049)T(0.001)PTTPTSSQAPQK 301.04 3.348599999999999e-89 262554000.0 126581.0 101833.0 126539.0 118811.0 131960.0 102806.0 104805.9 108473.0 87167.7 91727.5 True False 119546.13476389102 109643.26365529644 118397.61850524631 102628.73683959297 115382.00506263206 116966.59332004985 109679.58201895107 108788.63847132806 104603.67566903362 89079.08873833349 1.3420224258810431 1.2308530004990221 1.32912920621623 1.152108068157961 1.2952759923438644 1.3130645472096698 1.2312607096950752 1.2212589959343954 1.1742786904376965 1.0 16.44279917926236 -8.77385990436168 0.8483887120951623 0.9991115816472246 1.272799833439441 0.7126235887579351 0.05243555786114416 0.5149879674216329 0.7311575105223231 0.04973355656787223 0.017142441404162965 1.6832169492087686e-09 8.77385990436168 0.27368825179221645 S(ph)PGTSGEGVSPVITVRPVNVTAEK ddPTM_A459_Selumetinib_30min_R2 2 SPGTSGEGVSPVITVRPVNVTAEK 24 1 A0A075B6G6;Q7Z7B0-3;Q7Z7B0-2;Q7Z7B0 A0A075B6G6 FILIP1 Filamin-A-interacting protein 1 1 S(0.931)PGT(0.046)S(0.018)GEGVS(0.004)PVIT(0.002)VRPVNVTAEK;S(0.439)PGT(0.439)S(0.12)GEGVS(0.002)PVIT(0.001)VRPVNVTAEK 59.242 0.0054378 9222100.0 24259.6 22527.0 24479.8 24001.6 28074.0 20561.5 22422.2 25822.1 21553.9 26682.6 True False 22911.348550873307 24254.74846427844 22904.79631959097 20732.5406749306 24547.09313525562 23393.65998628685 23464.876728746418 25897.23803592123 25865.282266284255 25912.204008279445 0.8841914236069109 0.9360357172446073 0.8839385608523478 0.8001071876520482 0.947317840173393 0.9028047162183552 0.9055531023624598 0.9994224353762639 0.9981892029724605 1.0 14.66134411126132 -7.733451528035255 4.447139054213563 1.000553555630298 0.8932477270928155 0.6285980474704952 0.03704744394677115 0.1356520588110264 6.144075137136232 0.020324644235263426 0.010554519673111527 1.847346967320074e-08 7.733451528035255 -0.1073058285374825 S(ph)PGVAAAVAEDGGLK ddPTM_A459_Selumetinib_30min_R1 2 SPGVAAAVAEDGGLK 15 0 E9PLH8;E9PM78;H0YD80;E9PLS2;E9PQV9;E9PM04;Q9BTE7 E9PLH8 DCUN1D5 DCN1-like protein;DCN1-like protein 5 1 S(1)PGVAAAVAEDGGLK;S(1)PGVAAAVAEDGGLK 125.67 0.0012092 9394000.0 2496.2 3335.1000000000004 2703.3 2734.7 2277.0 2395.0 3007.5 3025.7 1480.25 2614.9 True False 2554.356603240318 2944.624941554073 2336.2067081639866 2257.1359816767686 2071.0457520370014 2370.9084744860124 2780.6418536478595 2945.4486071412744 2511.8761368175374 2950.547886282941 0.8657228086741072 0.9979925949494317 0.7917874232866993 0.7649887643478571 0.7019190441427053 0.8035485495789901 0.9424154295461625 0.998271751776891 0.8513253245253931 1.0 11.526767157587827 -7.268144103738266 22.102507442430735 0.9478591644877004 0.8197529668312611 0.36818979796470963 0.08149828906551214 137.13817144446367 452075.82260390156 0.03698025278209632 0.025669713717679017 5.393316365878499e-08 7.268144103738266 -0.12810619765643927 S(ph)PGVAAAVAEDGGLKK ddPTM_A459_Selumetinib_30min_R1 2 SPGVAAAVAEDGGLKK 16 1 E9PLH8;E9PM78;H0YD80;E9PLS2;E9PQV9;E9PM04;Q9BTE7 E9PLH8 DCUN1D5 DCN1-like protein;DCN1-like protein 5 1 S(1)PGVAAAVAEDGGLKK;S(1)PGVAAAVAEDGGLKK 123.72 0.00069008 83569000.0 7080.299999999999 7874.6 8048.0 8775.9 7026.9 6648.1 7316.7 6643.3 3923.4 5878.4 True False 7245.257214134457 6952.638171197775 6955.1258044996 7243.353809045654 6391.318135699955 6581.226149991841 6764.795428291038 6467.0981035203895 6657.7232462016045 6632.949900464889 1.0923129712809458 1.048196997645117 1.0485720394197657 1.09202600920263 0.9635709950488246 0.9922019989221655 1.0198773592149262 0.9749957711978384 1.003734891128151 1.0 12.695434913714855 -6.2595460230729945 24.999999502162986 0.9925109083061657 1.0671495074907573 0.7826472214817056 0.020079201881972594 78.78226413313322 1040250.8018796179 0.006004001237266461 0.007369190731068189 5.501156205461451e-07 6.2595460230729945 0.07463859918459159 S(ph)PGVAAAVAEDGGLKK ddPTM_A459_Selumetinib_30min_R2 3 SPGVAAAVAEDGGLKK 16 1 E9PLH8;E9PM78;H0YD80;E9PLS2;E9PQV9;E9PM04;Q9BTE7 E9PLH8 DCUN1D5 DCN1-like protein;DCN1-like protein 5 1 S(1)PGVAAAVAEDGGLKK;S(1)PGVAAAVAEDGGLKK;S(1)PGVAAAVAEDGGLKK 163.64 1.5646e-05 46467000.0 134966.0 116199.0 128291.0 141733.0 143692.0 102246.0 115470.0 124567.0 91851.9 121908.0 True False 127465.13003170576 125111.08966132585 120036.89673267973 122428.7208969374 125640.12633722127 116329.45840322386 120839.5837994643 124929.46934682311 110224.84655651684 118388.1992849772 1.0766709080934587 1.0567868285602156 1.0139261975235714 1.0341294287468137 1.0612554891116102 0.9826102525911585 1.0207063248642396 1.055252720299429 0.931045891585782 1.0 16.853165757417898 -1.5228787452803376 0.20198133878876706 0.9862241094861526 1.3997174025107733 0.3602563166251974 0.03331850396799309 62.38443630908488 0.7583980427196846 0.05937186158334667 8.187512337756226 0.029999999999999995 1.5228787452803376 0.4134932930246207 S(ph)PGYEPR ddPTM_A459_Selumetinib_30min_R2 1 SPGYEPR 7 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 S(1)PGYEPR 81.525 0.042863 52729000.0 79546.0 85480.0 103000.0 98661.0 104660.0 77347.0 87242.0 95287.0 81496.0 92670.0 True False 75125.15176786784 92036.04113847941 96373.09213792083 85223.20160028184 91511.67512772867 88000.84716384161 91298.9258667434 95564.26939438807 97797.47718849503 89994.37631442421 0.8347760698445649 1.0226865822917868 1.0708790491664784 0.9469836348721087 1.0168599292027236 0.9778482919464038 1.014495900807861 1.0618915682075918 1.0867065387153547 1.0 16.45754723080529 -4.761195207642603 24.999999686681896 1.0213754140277653 0.8347758637435729 0.659187609026928 0.04039234701485711 3.7164299245228554 379758.14833307714 0.010458169463837 0.05902785072377001 1.7330248588228278e-05 4.761195207642603 -0.1865995502841924 S(ph)PGYESESSR ddPTM_A459_Selumetinib_30min_R1 2 SPGYESESSR 10 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 S(1)PGYESESSR;S(1)PGYESESSR 119.74 0.0053049 15179700.0 681.29 987.0899999999999 709.98 804.16 976.45 834.22 866.12 844.85 401.15 760.79 True False 697.1627314404277 871.5210439143088 613.5686156409826 663.728551952751 888.1302699062493 825.8285042111564 800.7878710827871 822.4418335404388 680.7222511632189 858.44480722215 0.8121229525476232 1.0152324722360107 0.7147443964702114 0.7731755686198589 1.0345805140113302 0.9620053581353274 0.9328355933261039 0.958060234765455 0.7929714821922853 1.0 9.745581570470874 -6.252095218470775 24.977543750848525 0.9447130380689974 0.8339859335092914 0.278731968077889 0.09274767353406152 998.530924621621 2669136.578089661 0.028085170929855904 0.035757565554853585 5.596348888598552e-07 6.252095218470775 -0.11072710455970602 S(ph)PGYESESSR ddPTM_A459_Selumetinib_30min_R2 1 SPGYESESSR 10 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 S(1)PGYESESSR 94.82 0.023427 34027000.0 57324.0 50973.0 73136.0 72838.0 70906.0 53995.0 46778.0 52890.0 42780.0 57483.0 True False 54138.16156615367 54882.465195972174 68430.5093844561 62917.33874744159 61998.15437231724 61432.3211321917 48953.26968884853 53043.90114358912 51337.19537307122 55823.3164312296 0.9698127060015876 0.9831459093546244 1.2258409883038333 1.1270799151632513 1.110613957318258 1.1004778121319967 0.8769323074732673 0.950210495088293 0.919637145462596 1.0 15.768580216184896 -7.25088381761812 24.59109712386695 0.9325458619717751 1.0907997647810468 0.49550788378245536 0.07374786590370394 495.7322279866605 1154900.0108401375 0.030381809342284676 0.023270632374978884 5.611980875643685e-08 7.25088381761812 0.15825390280927165 S(ph)PGYESESSRYESQNTELK ddPTM_A459_Selumetinib_30min_R1 1 SPGYESESSRYESQNTELK 19 1 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 S(0.937)PGY(0.013)ES(0.004)ES(0.038)S(0.007)RYESQNTELK 71.685 0.007686399999999999 8860700.0 841.85 988.62 1591.7 1778.5 1283.9 999.28 1061.8 991.97 619.25 746.39 True False 861.4634670450531 872.8719108030313 1375.5558825822588 1467.9183615797451 1167.7714716909554 989.228150473645 981.7075711399153 965.6597332273295 1050.8220217694713 842.1964269542717 1.0228771334977742 1.03642319400439 1.63329579485018 1.74296436626826 1.386578515791259 1.1745812720330582 1.1656515507791612 1.14659680606762 1.2477160768416882 1.0 9.71801294461409 -6.7780540596950525 6.4593876655833995 1.1560566236202485 1.3825820936186277 0.1967785610663514 0.21796211351542283 0.3039052711725064 48.383966923941124 0.08554987842916062 0.07824838759708275 1.6670396914559e-07 6.7780540596950525 0.2265254699983792 S(ph)PHEAGFCVYLK ddPTM_A459_Selumetinib_30min_R1 1 SPHEAGFCVYLK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 S(1)PHEAGFCVYLK 104.59 0.0096778 27537000.0 1287.3 1364.2 1248.6 816.65 1380.6 949.09 1388.8 1321.9 773.16 1289.9 True False 1317.2915853502375 1204.4788298006263 1079.046978068863 674.0374079190888 1255.7249737647273 939.5430163047721 1284.0416978707053 1286.8389178636517 1311.9960506278305 1455.4712296899947 0.9050619197954269 0.827552482818346 0.741372935484745 0.46310596470028065 0.8627617971068985 0.6455249661684404 0.8822171621655464 0.8841390277001486 0.901423555385067 1.0 10.507270606641626 -7.410016849411407 5.819767721306998 0.9128696071003212 0.738108488779153 0.3422387245649644 0.12012444391435613 0.2977731384580381 13.285425177452598 0.052997154949643535 0.035210177710643456 3.8903005142340366e-08 7.410016849411407 -0.17476111832116814 S(ph)PHEAGFCVYLK ddPTM_A459_Selumetinib_30min_R2 1 SPHEAGFCVYLK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 S(1)PHEAGFCVYLK 90.689 0.015919 5102400.0 76670.0 60710.0 60691.0 79794.0 83602.0 62198.0 75377.0 78701.0 74624.0 58789.0 True False 72408.98833432772 65366.26178658248 56786.20713536452 68925.91954767234 73099.16934863722 70765.20992277177 78882.1798566919 78930.0068803481 89550.88516877193 57091.60881783407 1.2682947605377142 1.1449364125497126 0.994650673035962 1.2072863416338253 1.280383770264375 1.239502816404543 1.381677298819629 1.38251502304297 1.568547235277741 1.0 15.800991097002662 -6.579722679464603 1.3721601131302263 1.3571671182321057 1.1392054895960098 0.2000641402584935 0.149178983350861 0.5576233155737865 2.17921685724081 0.06317511354467138 0.06697632894795635 2.6319480967485396e-07 6.579722679464603 -0.21796162863609592 S(ph)PHGQTRPPASLK ddPTM_A459_Selumetinib_30min_R2 1 SPHGQTRPPASLK 13 1 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3;H7C103 Q9H8V3-2 ECT2 Protein ECT2 1 S(1)PHGQTRPPASLK 71.531 0.031669 3884400.0 17788.0 15902.0 17719.0 21301.0 19040.0 18141.0 18943.0 17619.0 16124.0 21235.0 True False 16799.41417100589 17121.63226701096 16578.978830988508 18399.767053725427 16648.02498024034 20639.75808239818 19823.887034842395 17670.268373017534 19349.25054220197 20621.89037484404 0.8146398737284987 0.8302649250767559 0.8039504880315267 0.892244441187152 0.8072986849231202 1.000866443726999 0.9613030946486312 0.8568694747098893 0.9382869460796611 1.0 14.331888967803897 -6.750733790698874 24.999997911545854 0.9431344061728449 0.8317586032581854 0.6509211999701501 0.04437041512160501 150.6978770092395 351913.5019360911 0.015099331791515977 0.014951454228253556 1.775277338428229e-07 6.750733790698874 -0.11137580291465954 S(ph)PHIPYK ddPTM_A459_Selumetinib_30min_R2 1 SPHIPYK 7 0 Q9UPT9-2;Q9UPT9 Q9UPT9-2 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 S(1)PHIPYK 70.268 0.044577 4644700.0 77869.0 68832.0 74233.0 82912.0 89340.0 84382.0 85154.0 93779.0 78648.0 79219.0 True False 73541.352714305 74111.19307023619 69456.92959877936 71619.24256882226 78116.31049026645 96004.85455647006 89113.82972945001 94051.88136405085 94379.7976087262 76931.74163431927 0.9559299081498784 0.9633369984331039 0.9028383879430412 0.930945290557063 1.0153976607156225 1.2479225416839161 1.1583493085732548 1.2225367496697133 1.2267991807249474 1.0 16.231291348998496 -6.6004991266934905 4.394830747942391 1.1834392267330318 0.9406537191014652 0.7312621443933883 0.06684906259477394 0.1008620245964594 3.6948348050106072 0.021401989625509515 0.02151989576048852 2.509001224716929e-07 6.6004991266934905 -0.2427855076315666 S(ph)PHQLLSPSSFSPSATPSQK ddPTM_A459_Selumetinib_30min_R1 2 SPHQLLSPSSFSPSATPSQK 20 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 S(0.988)PHQLLS(0.012)PSSFSPSATPSQK;S(0.999)PHQLLS(0.001)PSSFSPSATPSQK 129.04 0.00012136 44729000.0 6389.1 6726.4 6485.3 6811.0 7323.7 5435.200000000001 7441.0 6158.799999999999 2397.26 3817.4 True False 6537.95359897553 5938.869960981476 5604.631881202942 5621.586708304555 6661.272628104253 5380.52682276675 6879.719379216533 5995.448617398185 4067.9751310570587 4307.40047462484 1.5178420575219358 1.3787596477197146 1.3011634080044732 1.3050996166763844 1.5464716288504443 1.2491354947058586 1.5971859175262157 1.3918948685449006 0.9444153509806551 1.0 12.072601747061473 -8.257519121512725 22.401354441934995 0.9722075003489118 1.4080158444273143 0.7247702289011306 0.10813413782241417 36.75374011942743 210035.45911429045 0.07786885224194975 0.026772884341011258 5.526890731111759e-09 8.257519121512725 0.4358083440784025 S(ph)PHQLLSPSSFSPSATPSQK ddPTM_A459_Selumetinib_30min_R2 1 SPHQLLSPSSFSPSATPSQK 20 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 S(1)PHQLLSPSSFSPSATPSQK 146.04 1.6605e-05 31633000.0 54711.0 51682.0 58820.0 70589.0 69727.0 48725.0 45656.0 54237.0 42807.0 63590.0 True False 51670.38164548592 55645.84321617786 55035.585238373744 60974.656427182956 60967.270892711065 55436.42646848854 47779.09446564772 54394.82069058132 51369.59612751425 61753.99147333802 0.8367132295860479 0.9010890128487108 0.8912069313306669 0.9873800052828725 0.9872604092163562 0.89769786771472 0.7737005062462418 0.8808308482224345 0.8318425238908292 1.0 15.914244767950194 -7.0073360046618856 24.937209804800258 0.8579536311920247 0.9237791508299424 0.09099428087021166 0.06761074047700803 610.2802406206571 2074522.162107565 0.024408722964693687 0.020674212879650374 9.832500911410117e-08 7.0073360046618856 0.06582551963791772 S(ph)PIALPVK ddPTM_A459_Selumetinib_30min_R1 1 SPIALPVK 8 0 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 S(1)PIALPVK 99.688 0.018449 16036000.0 5998.4 5081.5 3414.2 2932.8 4382.1 3706.7 4643.6 4601.2 2431.8 4649.3 True False 6138.15104914539 4486.555617674741 2950.5703928581693 2420.6415354743194 3985.739828722594 3669.4139634143207 4293.32951341619 4479.161229196033 4126.586988355266 5246.082943017047 1.170044605816947 0.8552201073463208 0.5624330428830929 0.4614188455972442 0.7597553969343794 0.6994578628038282 0.818387654188913 0.853810600756542 0.786603458843151 1.0 12.357024902126481 -8.7182073124844 0.7865001735338254 0.9956569479282465 0.7420096078651338 0.12416772892359651 0.17906264545781386 1.982676215899671 2.545377428466682 0.1907445879886737 0.068427514460828 1.913342364144064e-09 8.7182073124844 -0.25364734006311274 S(ph)PIALPVK ddPTM_A459_Selumetinib_30min_R2 1 SPIALPVK 8 0 Q8TF01;Q8TF01-2 Q8TF01 PNISR Arginine/serine-rich protein PNISR 1 S(1)PIALPVK 89.029 0.030241000000000007 5175900.0 34246.0 25300.0 31112.0 33512.0 37994.0 24904.0 29831.0 29168.0 26477.0 28992.0 True False 32342.744417599944 27240.42864767812 29110.287792184354 28947.607788575515 33220.85404933041 28334.299943996677 31218.200609005085 29252.874050977654 31773.139829191376 28154.92562973762 1.1487419587938492 0.9675191121409464 1.033932327686125 1.0281542977332767 1.1799304493364418 1.0063709745363205 1.1088006773504666 1.038996672755561 1.128510877529442 1.0 14.781099719615368 S(ph)PIINESR ddPTM_A459_Selumetinib_30min_R1 3 SPIINESR 8 0 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 S(1)PIINESR;S(1)PIINESR;S(1)PIINESR 131.42 0.0035732 54327000.0 3741.54 2691.83 3419.15 3409.33 3215.85 2768.51 2957.24 2744.2 1661.6200000000001 2128.08 True False 3828.710602230503 2376.669292202184 2954.848210046574 2813.9545165502795 2924.9769353044326 2740.661303005956 2734.1730059124175 2671.4149015821417 2819.647780076847 2401.2397972545814 1.5944724082151216 0.9897675754497781 1.2305510734183864 1.171875678458923 1.218111135193019 1.1413526071571223 1.1386505458715492 1.1125148369756577 1.1742466467949788 1.0 11.229563768628271 -4.749274242642907 24.99784888544548 1.1420083233041483 1.5944734401961693 0.7628956871568904 0.07732275146353877 263.30734704451794 541031.0388397609 0.018102074757771956 0.3028644606354082 1.7812536093242764e-05 4.749274242642907 0.45246511689202107 S(ph)PIINESR ddPTM_A459_Selumetinib_30min_R2 2 SPIINESR 8 0 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 S(1)PIINESR;S(1)PIINESR 93.561 0.02389 11963000.0 17517.1 15719.800000000001 16554.5 18361.7 26350.0 14348.7 11918.5 15504.2 13676.3 15126.1 True False 16543.56970850727 16925.4581128763 15489.401493176787 15860.804784300744 23039.67742801118 16325.103180470025 12472.733866059707 15549.31465514151 16411.942147749727 14689.370190672402 1.1262272986361435 1.152224900943935 1.0544632814150465 1.0797470945604046 1.568459173466888 1.111354875570928 0.849099294534749 1.0585419560748197 1.117266563148578 1.0 13.842484920966308 -7.003794592646446 24.99821579148094 1.0066942340017566 1.1954807039208373 0.2682180295526092 0.1479376974058035 233.42290558042419 1537762.8329519795 0.055557028608276916 0.04794860833923182 9.913006874485429e-08 7.003794592646446 0.18878646991908066 S(ph)PILEEK ddPTM_A459_Selumetinib_30min_R1 1 SPILEEK 7 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;A0A0A0MR81 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 S(1)PILEEK 87.149 0.03397 104250000.0 4368.9 6888.1 4331.5 4070.9 5089.4 4562.5 6197.3 5757.0 2342.5 5034.8 True False 4470.686869600444 6081.638049809189 3743.3060912263936 3359.993735257231 4629.064668606551 4516.605392418551 5729.832671525143 5604.305658628524 3975.0514105692164 5681.065623105034 0.7869451201933049 1.0705100861843626 0.6589091447918284 0.5914372334640976 0.814823305293294 0.7950278507696522 1.0085841374938131 0.9864884566437103 0.6997017239868845 1.0 12.47194585259177 -7.15564850333669 7.673097895145976 0.922291357558537 0.785060520650538 0.18267842749399366 0.14246625570718996 0.5400851660845626 34.8198181947465 0.05739670298456521 0.04441995957619045 6.987977479056358e-08 7.15564850333669 -0.13723083690799898 S(ph)PILEEK ddPTM_A459_Selumetinib_30min_R2 4 SPILEEK 7 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;A0A0A0MR81 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 S(1)PILEEK;S(1)PILEEK;S(1)PILEEK;S(1)PILEEK 118.71 0.010672 211803000.0 841080.0 616360.0 742000.0 710530.0 717260.0 585280.0 667030.0 752450.0 588590.0 689690.0 True False 794336.1407100088 663632.8300902327 694260.5278285157 613754.5882673834 627151.386414243 665897.0073571461 698048.2166948695 754639.5049251968 706324.4465786824 669776.8576701751 1.1859713150930808 0.9908267544487659 1.0365549658486368 0.9163568153165732 0.9363586980233907 0.9942072493717906 1.0422101162513087 1.1267028657129436 1.0545668135438993 1.0 19.353321002913106 -7.472303137124015 5.2504905494006175 1.0710609471636965 1.0034687317769329 0.07764097071758846 0.07429687467653366 0.42111734810522194 26.321553343896863 0.033575302810195114 0.02163846931753276 3.37051964591511e-08 7.472303137124015 -0.06759221538676363 S(ph)PILEEKDIPPLEFPK ddPTM_A459_Selumetinib_30min_R1 2 SPILEEKDIPPLEFPK 16 1 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;A0A0A0MR81 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 S(1)PILEEKDIPPLEFPK;S(1)PILEEKDIPPLEFPK 78.021 0.014776 45515000.0 3382.7000000000003 4030.5 10337.9 11100.400000000001 6436.599999999999 6321.799999999999 4433.299999999999 4517.6 2901.0099999999998 2860.2 True False 3461.5103284115967 3558.6071862713834 8934.069962019932 9161.923520314764 5854.410666474031 6258.208431735145 4098.892611729692 4397.778572767102 4922.802088612761 3227.3345307072796 1.0725601252290995 1.102645899398444 2.7682503555223343 2.8388515145056568 1.814008002818047 1.9391260410688322 1.2700550788056695 1.3626658565833012 1.5253460841364699 1.0 11.656127413394337 -7.256632677851897 20.103870153255844 1.3197386453161999 1.9604587118028831 0.23338825773077965 0.5584827110516768 46.57562286453773 194806.6034599975 0.2441876329055228 0.1818676334073294 5.538183254612103e-08 7.256632677851897 0.6407200664866832 S(ph)PISDNSGCDAPGNSNPSLSVPSSAESEK ddPTM_A459_Selumetinib_30min_R1 2 SPISDNSGCDAPGNSNPSLSVPSSAESEK 29 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 S(0.986)PIS(0.013)DNS(0.001)GCDAPGNSNPSLSVPSSAESEK;S(0.987)PIS(0.013)DNSGCDAPGNSNPSLSVPSSAESEK 155.83 8.618000000000001e-19 31118000.0 6397.299999999999 7568.4 5599.7 5383.1 6378.299999999999 5686.9 7452.4 7074.799999999999 3818.9 7037.1 True False 6546.344643021108 6682.288209546294 4839.291496950353 4443.0426383019 5801.383891180325 5629.694949292067 6890.2594680383345 6887.153321810852 6480.3943785796255 7940.380332158662 0.8244371641126952 0.8415577000112858 0.609453363002166 0.5595503555802622 0.7306178858567557 0.7089956291503715 0.8677492991277355 0.8673581155700786 0.8161314833162246 1.0 12.954992396586738 -7.27292151042918 4.864829367545043 0.8786018961786143 0.7068112629529911 0.4706896055209372 0.0908397914888845 0.19936516880532482 13.92016454433396 0.041234536501898005 0.028886316671188114 5.334312932356689e-08 7.27292151042918 -0.17179063322562316 S(ph)PISFLSK ddPTM_A459_Selumetinib_30min_R2 1 SPISFLSK 8 0 Q7RTP6;A0A5F9ZHV5;J3KSK6;Q7RTP6-2;Q7RTP6-4;Q7RTP6-3;Q7RTP6-5 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 S(0.999)PIS(0.001)FLSK 88.056 0.031604 5120000.0 32528.0 32280.0 38285.0 41295.0 41972.0 32265.0 43429.0 35445.0 32904.0 32631.0 True False 30720.22397990101 34755.77220344068 35821.784781556235 35670.54976215164 36699.1021255592 36709.21087749171 45448.53455293095 35548.13908176437 39485.719414575404 31688.85824448017 0.9694329705063487 1.0967820908945098 1.1304220715429523 1.1256495733280336 1.1581074282457544 1.1584264284399084 1.4342118041077594 1.1217866799589236 1.246044244003438 1.0 14.951688059632469 -4.119394739107685 0.6178748087918229 1.203672996445919 0.5905379163562414 0.26744985098429797 0.10464885367652431 9.160619726581565 1.45648414173088 0.0475690150930765 4.786009798809142 7.596355148592605e-05 4.119394739107685 -0.6131350800896775 S(ph)PISPELHSAPLTPVAR ddPTM_A459_Selumetinib_30min_R1 3 SPISPELHSAPLTPVAR 17 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 S(0.99)PIS(0.01)PELHSAPLTPVAR;S(0.996)PIS(0.004)PELHSAPLTPVAR;S(0.978)PIS(0.022)PELHSAPLTPVAR 107.02 0.0016468 28132100.0 4666.3099999999995 5225.700000000001 4681.73 5423.5 4741.8 4556.6900000000005 5092.700000000001 5123.8 3006.3599999999997 4903.7 True False 4775.02594394132 4613.872614637982 4045.9767809020764 4476.387536703826 4312.905027232787 4510.853835743491 4708.5535388437065 4987.900179551993 5101.5733441531975 5533.137661082894 0.8629870132323433 0.8338618876391733 0.7312264810180479 0.8090143081362898 0.7794682314823711 0.8152433776355148 0.8509735031465298 0.9014596211177236 0.9220036906066721 1.0 12.433882102260108 -8.070953522859517 0.9283750233917595 0.9933308963412039 0.7996853015368388 0.7860689908459774 0.03358610334228692 0.24774659436992688 0.4147922302458552 0.03282657082700503 0.012284349971241936 8.49271357130862e-09 8.070953522859517 -0.19364559480436505 S(ph)PISPELHSAPLTPVAR ddPTM_A459_Selumetinib_30min_R2 2 SPISPELHSAPLTPVAR 17 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 S(1)PISPELHSAPLTPVAR;S(0.912)PIS(0.088)PELHSAPLTPVAR 201.22 3.0439e-08 39964000.0 40074.0 27301.0 43646.0 41191.0 50251.0 39183.0 38163.0 46738.0 37983.0 43586.0 True False 37846.84750893243 29394.898913449015 40837.86387817172 35580.71474156166 43938.02013036016 44580.10258214031 39937.65511854989 46873.99984210758 45580.66133369249 42327.558929971885 0.894141983749819 0.6944624177850868 0.9648055524707966 0.8406039857017875 1.038047580373172 1.0532169515349352 0.9435378776419417 1.1074108932116185 1.076855421998293 1.0 15.369309669028544 -6.041370011258777 1.1530040093490639 1.0456051401737372 0.8074998460527101 0.5722320885632224 0.07770306902498518 0.3379496128197651 0.9168767312261774 0.02934266750040684 0.05530743723841629 9.09138372677965e-07 6.041370011258777 -0.2381052941210271 S(ph)PISVPGGSALISNLGK ddPTM_A459_Selumetinib_30min_R1 2 SPISVPGGSALISNLGK 17 0 P51610;A6NEM2;P51610-2;P51610-4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 S(0.996)PIS(0.004)VPGGSALISNLGK;S(1)PISVPGGSALISNLGK 246.03 6.1618e-24 119306000.0 6481.6 7774.700000000001 5401.7 5539.299999999999 5947.6 5344.7 8134.3 7125.5 3518.1000000000004 6747.9 True False 6632.608669001862 6864.43450964003 4668.178809414203 4571.9652405390425 5409.640630134068 5290.937170599326 7520.723202037497 6936.508593114041 5969.958748142392 7614.058695112114 0.8711002810182827 0.9015473592351857 0.6130999242770436 0.6004636191567633 0.7104805527184621 0.6948905153562674 0.9877416898382285 0.9110132809413422 0.7840704921246325 1.0 12.89444997602546 -7.2534368484084 24.971025619181802 0.913290807237461 0.7272880954618459 0.43359454920967555 0.10548375442267104 645.0830862942864 2012915.7352029698 0.04465200867128421 0.033964872159895465 5.5790872281799813e-08 7.2534368484084 -0.18600271177561511 S(ph)PISVPGGSALISNLGK ddPTM_A459_Selumetinib_30min_R2 2 SPISVPGGSALISNLGK 17 0 P51610;A6NEM2;P51610-2;P51610-4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 S(0.995)PIS(0.005)VPGGSALISNLGK;S(0.995)PIS(0.005)VPGGSALISNLGK 191.44 7.8928e-08 89232000.0 84571.0 64484.0 83678.0 88663.0 92755.0 77607.0 93329.0 96776.0 77064.0 72800.0 True False 79870.88238453663 69429.71545125992 78294.24858171788 76586.94644779398 81102.28765977907 88296.65980379665 97668.98342790498 97057.60213787077 92478.95334806807 70698.07484288407 1.1297462139108845 0.9820594917974373 1.107445269983874 1.0832960673681291 1.1471640188225325 1.2489259431748714 1.3814942435838562 1.3728464651062537 1.3080830496953242 1.0 16.10938330954255 -6.664805581029567 2.2086372122518423 1.2984119941575336 1.071367034943081 0.39029743479423973 0.10723165251383121 0.26068253985037754 2.6022109048939766 0.03877849303734576 0.03805685243923136 2.163686916502392e-07 6.664805581029567 -0.22704495921445256 S(ph)PKPAAPAAPPFSSSSGVLGTGLCELDR ddPTM_A459_Selumetinib_30min_R1 2 SPKPAAPAAPPFSSSSGVLGTGLCELDR 28 1 O43294-2;O43294;H3BQC4;H3BSN4;H3BS04;H3BN49 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 S(1)PKPAAPAAPPFSSSSGVLGTGLCELDR;S(0.984)PKPAAPAAPPFS(0.013)S(0.002)S(0.001)S(0.001)GVLGTGLCELDR 94.968 8.005e-07 173223000.0 3603.6 5181.9 3896.6 3495.2 3917.0 3676.5 4168.8 4050.7999999999997 2677.3199999999997 4434.4 True False 3687.556868615019 4575.200739000047 3367.4631224916957 2884.8289330298144 3562.708041602519 3639.517747994913 3854.3440596798637 3943.3596251471954 4543.216496283957 5003.598434713783 0.7369809781359794 0.9143820789570934 0.6730082692346038 0.5765508504870321 0.7120291702238319 0.7273800636647416 0.7703144267012588 0.7881047363411697 0.9079898308313863 1.0 12.28875029489048 -8.314842836013549 1.2535085058823423 1.000658460782593 0.7239774246648536 0.5743797107642592 0.0785786871854922 0.34610726375326367 1.1088829444457593 0.08140416033191114 0.025809560051942158 4.8434761325935965e-09 8.314842836013549 -0.2766810361177394 S(ph)PKPAAPAAPPFSSSSGVLGTGLCELDR ddPTM_A459_Selumetinib_30min_R2 2 SPKPAAPAAPPFSSSSGVLGTGLCELDR 28 1 O43294-2;O43294;H3BQC4;H3BSN4;H3BS04;H3BN49 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 S(1)PKPAAPAAPPFSSSSGVLGTGLCELDR;S(0.994)PKPAAPAAPPFS(0.002)S(0.002)S(0.001)S(0.001)GVLGTGLCELDR 84.529 1.9666e-05 89893000.0 186195.0 169901.0 170291.0 167903.0 180220.0 138640.0 155967.0 166386.0 121270.0 177430.0 True False 175847.0272976412 182931.86038218046 159334.66245882187 145034.3217511697 157579.15241275803 157736.40155138538 163219.77454274762 166870.15571331474 145527.38856690863 172307.13488149614 1.0205440849479601 1.0616615528311781 0.9247130861319466 0.8417197688935907 0.914524825226377 0.9154374347868314 0.9472606845619113 0.9684460009626377 0.8445813266351088 1.0 17.394622916249432 -5.280427828486795 10.926545638215616 0.916312942812535 1.041107827536419 0.5134408697086491 0.04723174507274445 0.4491504410126614 257.9345600641923 0.012122769977526633 0.025957855866479827 5.242907209521665e-06 5.280427828486795 0.124794884723884 S(ph)PLAEEGR ddPTM_A459_Selumetinib_30min_R2 1 SPLAEEGR 8 0 Q9BRS8 Q9BRS8 LARP6 La-related protein 6 1 S(1)PLAEEGR 117.71 0.008728399999999999 5924300.0 13710.0 5810.3 13044.0 11094.0 11869.0 7049.0 10170.0 12090.0 4507.9 10506.0 True False 12948.05308547845 6255.931326940872 12204.76324123337 9582.978061782544 10377.910109793727 8019.93576554902 10642.925151472686 12125.179898392751 5409.605961249827 10202.664482133812 1.2690854539176672 0.613166427054013 1.1962329313686137 0.9392622955075687 1.017176456989916 0.7860628740259926 1.0431515385132801 1.1884326804655305 0.5302150208627117 1.0 13.316658348723847 -8.255522743763558 24.9928577464271 0.7651075141984911 0.9917588096546103 0.1661300230579249 0.2143444730077803 780.7071711310182 3297873.022847421 0.14232154175971903 0.050550755566279554 5.55235538977855e-09 8.255522743763558 0.22665129545611917 S(ph)PLAQMEEER ddPTM_A459_Selumetinib_30min_R1 2 SPLAQMEEER 10 0 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;A0A0U1RRM2 E7EPK1 SEPT7 Septin-7 1 S(1)PLAQMEEER;S(1)PLAQMEEER 159.66 0.00045512 20934000.0 1075.83 1209.68 1045.9299999999998 1235.33 1253.92 1018.41 1013.94 1030.77 508.83000000000004 796.54 True False 1100.8947457992274 1068.0501032350246 903.8984508822407 1019.6028055160574 1140.5031573975564 1008.1657200422962 937.4576894722233 1003.4306311871676 863.447346527186 898.7836679566386 1.224871773985483 1.1883283389686072 1.0056907831194022 1.1344251590976258 1.268940678450979 1.121700088670208 1.0430292882418626 1.1164317587884536 0.960684286231203 1.0 9.811830098925343 -7.786405928972136 1.1198158980073543 0.9891881587069511 1.1551454440121687 0.4384647442534212 0.07303810689698303 0.5393188523731606 1.222002482782115 0.06723229540056179 0.026228060506338583 1.6352873267103492e-08 7.786405928972136 0.16595728530521758 S(ph)PLAQMEEER ddPTM_A459_Selumetinib_30min_R2 4 SPLAQMEEER 10 0 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;A0A0U1RRM2 E7EPK1 SEPT7 Septin-7 1 S(1)PLAQMEEER;S(1)PLAQMEEER;S(1)PLAQMEEER;S(1)PLAQMEEER 144.51 0.00097299 44432400.0 15304.900000000001 6211.5 6033.5 11264.099999999999 9153.8 10760.5 12579.8 11854.58 13110.1 6056.5 True False 14454.31492836902 6687.902076879551 5645.311178778101 9729.910148343673 8003.817807989709 12242.661200906547 13164.78562640081 11889.074865168634 15732.486326799928 5881.633108323189 2.4575342701867102 1.1370824996573483 0.9598203551305052 1.6542871629606968 1.360815552514383 2.0815071214798775 2.238287459272344 2.0213900877877307 2.6748500011904257 1.0 12.522001077504644 -6.767846674691742 24.50677123135503 2.081736513580792 1.4699893963236292 0.15942733604217685 0.5424312392905414 178.3013524462805 681965.6964069334 0.1822223576318901 0.16462791337012284 1.7066848184610905e-07 6.767846674691742 -0.6117471172571627 S(ph)PLAQMEEERR ddPTM_A459_Selumetinib_30min_R1 2 SPLAQMEEERR 11 1 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;A0A0U1RRM2 E7EPK1 SEPT7 Septin-7 1 S(1)PLAQMEEERR;S(1)PLAQMEEERR 164.88 0.00033733 114406000.0 3381.7 3897.3999999999996 3537.6000000000004 4026.9 4042.6000000000004 3016.3599999999997 3893.7 3180.42 2216.95 2901.11 True False 3460.487030357257 3441.0905961478943 3057.2133506458476 3323.6775092749385 3676.947543778997 2986.0181570357518 3599.9950741641446 3096.0649301398844 3762.0022303784062 3273.495727704425 1.0571228186034511 1.0511975216662333 0.9339292319131121 1.0153297226404825 1.123248004468146 0.9121802517609302 1.099740269613451 0.9457977610714752 1.1492308355681136 1.0 11.676616380703637 -8.260179937402855 24.999988729237067 1.0746154060918465 1.0183753935963211 0.08701791486105714 0.07417374184460707 286.24659320172685 5682281.421322991 0.053296018630767134 0.017562049966712984 5.4931323459463385e-09 8.260179937402855 -0.05624001249552535 S(ph)PLAQMEEERR ddPTM_A459_Selumetinib_30min_R2 3 SPLAQMEEERR 11 1 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;A0A0U1RRM2 E7EPK1 SEPT7 Septin-7 1 S(1)PLAQMEEERR;S(1)PLAQMEEERR;S(1)PLAQMEEERR 111.88 0.0041042000000000006 135455000.0 54138.3 55549.5 64683.5 61205.3 70459.5 54306.8 35645.1 51076.4 44741.4 60902.9 True False 51129.510018786175 59809.96803020533 60521.83403206988 52869.0325549684 61607.74769407799 61787.06875195312 37302.6677794257 51225.0238678468 53690.93017916619 59144.47503226226 0.8644849749853378 1.0112519892615508 1.0232880416819372 0.8938963872133329 1.041648398442493 1.0446803140656735 0.6307041825813444 0.8660998992704638 0.9077928268004535 1.0 15.851955785378385 S(ph)PLEATR ddPTM_A459_Selumetinib_30min_R1 1 SPLEATR 7 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 S(1)PLEATR 101.46 0.019909 12681000.0 1532.3 1593.6 862.23 1221.6 1341.5 1268.3 1391.5 1151.7 737.66 1349.6 True False 1567.9996086632245 1407.0205711554588 745.1439018903692 1008.2704922720372 1220.161561861062 1255.5420535242615 1286.5380346969223 1121.1531747511674 1251.7551434452448 1522.8343062172385 1.0296587109060984 0.9239485644702449 0.4893138398893355 0.6621012464426339 0.8012438102290828 0.8244771268931167 0.8448312659127818 0.7362279469104831 0.8219903756664364 1.0 10.572543260891072 -6.5151314125184445 23.228106614773075 0.8271867162799186 0.7619796661599124 0.0363606741546576 0.14855704267224468 621.6540787483767 1863861.911399906 0.05153884013202753 0.05385033983916093 3.053996869039792e-07 6.5151314125184445 -0.06520705012000616 S(ph)PLEATR ddPTM_A459_Selumetinib_30min_R2 1 SPLEATR 7 0 Q92610;H0YM74 Q92610 ZNF592 Zinc finger protein 592 1 S(1)PLEATR 91.265 0.028563 24306000.0 9204.8 9871.5 14250.0 16025.0 16185.0 12399.0 12395.0 16092.0 15548.0 12681.0 True False 8693.234065733923 10628.61230812468 13333.17051422689 13842.367355333081 14151.695604264176 14106.849703084446 12971.392060226552 16138.825055825992 18658.034447417285 12314.866580805141 0.7059137838556723 0.863071657202622 1.0826889943744054 1.124037135482151 1.1491554140198361 1.1455138072768423 1.0533116193434624 1.3105156235294626 1.5150821427898433 1.0 13.588113377321081 -4.290278839095388 0.5715455620034188 1.229571433966377 1.169603707300032e-12 0.6029659817248738 0.13297138310894288 4.511775210697278 0.7436251736110387 0.07036366664913227 4.148776949610184 5.125322066435963e-05 4.290278839095388 -1.2295714339652075 S(ph)PLELEPEAK ddPTM_A459_Selumetinib_30min_R1 3 SPLELEPEAK 10 0 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 S(1)PLELEPEAK;S(1)PLELEPEAK;S(1)PLELEPEAK 143.97 0.0010313 66700000.0 11689.6 11422.2 8869.6 9809.900000000001 9477.2 9701.8 11860.8 10962.0 6287.599999999999 10650.7 True False 11961.944935997928 10084.883513963281 7665.157037225356 8096.785119629545 8619.988933335564 9604.208700529596 10966.130306815141 10671.252150405742 10669.597971865522 12017.821091603393 0.9953505585430537 0.839160729477774 0.6378158718455915 0.6737315406772534 0.71726720406565 0.7991638939640948 0.9124890629697385 0.8879523225604955 0.8878146787623717 1.0 13.552887729401414 -7.187433177893392 3.5443400630549324 0.9141352910888033 0.7629982756577383 0.3466567879280632 0.09719300116989397 0.31503425252734474 7.706145555619972 0.04375884495513343 0.03228000920649596 6.494815554502163e-08 7.187433177893392 -0.15113701543106506 S(ph)PLELEPEAK ddPTM_A459_Selumetinib_30min_R2 4 SPLELEPEAK 10 0 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 S(1)PLELEPEAK;S(1)PLELEPEAK;S(1)PLELEPEAK;S(1)PLELEPEAK 167.2 0.00030316 56445300.0 406781.0 302272.0 336042.0 377214.0 362087.0 292367.0 366719.0 341630.0 301227.0 289462.0 True False 384173.7404933635 325455.2904423308 314421.42357486556 325836.8024695547 316598.39396114927 332637.90040662047 383772.160139913 342624.0867401089 361480.81698560296 281104.47994740255 1.3666581925882015 1.1577734033382419 1.11852156761677 1.1591305927622428 1.1262659137285467 1.1833247925072568 1.3652296121773675 1.2188496135110236 1.2859304734426134 1.0 18.100746920493734 -7.037169825484874 24.990162097268016 1.2412452199222177 1.1765031942480404 0.0 0.10898023208464332 1626.6106774576065 1093603.930284007 0.03999509611565726 0.030989633203502835 9.179735640837739e-08 7.037169825484874 -0.0647420256741773 S(ph)PLELGEK ddPTM_A459_Selumetinib_30min_R2 2 SPLELGEK 8 0 Q15742;Q15742-2;Q15742-3 Q15742 NAB2 NGFI-A-binding protein 2 1 S(1)PLELGEK;S(1)PLELGEK 109.83 0.012283 6785400.0 49501.0 36745.0 44246.0 46761.0 45890.0 41230.0 47906.0 56782.0 43491.0 46150.0 True False 46749.93258820342 39563.22334620282 41399.26053140234 40392.0711327757 40124.887938194806 46909.05825132444 50133.72392393815 56947.22621923389 52190.41524007106 44817.52958789983 1.0431171244393023 0.8827622519578677 0.9237291950732515 0.901256082255838 0.8952945043411769 1.0466676472946268 1.1186186383970977 1.2706462570085284 1.164508970484661 1.0 15.451775506989632 -7.063444222527796 2.4395827602132005 1.1636404326425909 0.9251275979631345 0.6211763212520731 0.07603545247130827 0.17273621440809905 2.0319827508868173 0.031678382706446295 0.024124420677236847 8.64083629871887e-08 7.063444222527796 -0.2385128346794564 S(ph)PLGEAPPGTPPCR ddPTM_A459_Selumetinib_30min_R1 2 SPLGEAPPGTPPCR 14 0 M0QXZ5;Q96B54 M0QXZ5 ZNF428 Zinc finger protein 428 1 S(1)PLGEAPPGTPPCR;S(1)PLGEAPPGTPPCR 136.33 0.00084827 0.0 1448.76 2161.16 1686.77 1461.1599999999999 1718.89 1542.74 2140.8 1762.0900000000001 907.23 1198.17 True False 1482.513289203767 1908.130382503974 1457.715898764388 1205.995835370178 1563.4167029946775 1527.2214362958446 1979.3177324320327 1715.353649125019 1539.5030485424577 1351.9667906641293 1.0965604328753586 1.4113737080528725 1.0782187172277444 0.8920306650267306 1.156401705863409 1.1296294012855335 1.4640283667468847 1.2687838643450573 1.1387136571499692 1.0 10.40084399875807 S(ph)PLGFYVHLK ddPTM_A459_Selumetinib_30min_R1 2 SPLGFYVHLK 10 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(1)PLGFYVHLK;S(1)PLGFYVHLK 126.66 0.0022617 8243400.0 14041.6 15584.3 12719.099999999999 11062.5 11696.5 11309.0 11033.3 14181.099999999999 12595.2 13207.8 True False 14368.741959802597 13759.682911055494 10991.916081015268 9130.642043843649 10638.553640184795 11195.241727750436 10201.049298039208 13804.971161295285 21373.13448298885 14903.149784866664 0.9641412833677128 0.9232734763913936 0.7375565729183612 0.6126652536979342 0.7138459851613158 0.7511997053883598 0.6844894834511975 0.9263123138783373 1.434135386916134 1.0 13.86332965646282 -8.043485370718244 5.660041985591573 1.2131899273452866 0.767269255797149 0.6197521947086096 0.13877438321348018 0.13120541131982497 10.508217664349203 0.09534428514039847 0.03643570536486736 9.047209128990542e-09 8.043485370718244 -0.44592067154813764 S(ph)PLGFYVHLK ddPTM_A459_Selumetinib_30min_R2 1 SPLGFYVHLK 10 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(1)PLGFYVHLK 78.548 0.034566 1517500.0 9703.2 8754.0 10810.0 12807.0 10631.0 10515.0 9823.9 10431.0 11762.0 8597.9 True False 9163.9349889872 9425.403651453524 10114.49636903809 11062.66450669272 9295.438737654154 11963.345804333647 10280.73081568855 10461.352483054989 14114.728657738748 8349.656286972999 1.0975224217653876 1.1288373230595 1.2113667942018844 1.3249245389840194 1.1132720220060734 1.43279500295104 1.2312759306905103 1.252908158552182 1.6904562502483274 1.0 13.027501095028933 -5.150348677664963 0.6295050945313313 1.3224319170321939 1.0003325535402636 0.14099462546122477 0.17437565454556078 4.378470903407218 1.7964097330991107 0.08662495805565117 0.9533097441009221 7.073776311404881e-06 5.150348677664963 -0.32209936349193025 S(ph)PLGGGGGSGASSQAACLK ddPTM_A459_Selumetinib_30min_R1 2 SPLGGGGGSGASSQAACLK 19 0 J3QQY0;J3KSZ8;Q68DK7;Q68DK7-2 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 S(1)PLGGGGGSGASSQAACLK;S(1)PLGGGGGSGASSQAACLK 240.82 7.457e-30 12688600.0 1531.25 1722.06 1949.78 2086.3599999999997 1608.4 1430.84 1731.42 1439.83 839.2 1354.54 True False 1566.9251457061678 1520.4404146360253 1685.0105853749046 1722.0163918276746 1462.9205039860844 1416.447048698775 1600.8175954257613 1401.6410311730247 1424.0611072570684 1528.4084033369143 1.0252005565300226 0.9947867411069627 1.102460953300235 1.1266729416483603 0.9571528792907362 0.9267464413348563 1.047375552195839 0.9170592284842695 0.9317281324467803 1.0 10.57781437956853 -6.28740364133986 24.639488491942938 0.9615683819990746 1.0603293770974689 0.48761431902357266 0.04964860629970662 575.8146869847807 546433.4161056341 0.016207135472945187 0.018383674180095115 5.15936625304203e-07 6.28740364133986 0.09876099509839431 S(ph)PLGGGGGSGASSQAACLK ddPTM_A459_Selumetinib_30min_R2 4 SPLGGGGGSGASSQAACLK 19 0 J3QQY0;J3KSZ8;Q68DK7;Q68DK7-2 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 S(1)PLGGGGGSGASSQAACLK;S(1)PLGGGGGSGASSQAACLK;S(1)PLGGGGGSGASSQAACLK;S(1)PLGGGGGSGASSQAACLK 266.83 1.7083e-58 29860400.0 69826.0 74946.0 73672.0 77595.0 78587.0 59607.6 64336.0 71360.0 60181.0 78927.0 True False 65945.35045562494 80694.11721062787 68932.02372800859 67026.42714115883 68714.19848330598 67818.00583608166 67327.75147936541 71567.6457857161 72218.88159763435 76648.17243302634 0.8603642900063493 1.0527859262546253 0.8993302976433003 0.8744686926452838 0.8964884132540419 0.8847961234214644 0.8783999584359963 0.9337162715556003 0.9422127012974482 1.0 16.22596377282629 -8.587513344930876 1.6952670306520274 0.9991956078879334 0.9101460078398509 0.22797620988279732 0.05141571990630215 0.7174168585561214 4.540489063377758 0.050299041100738184 0.014413001972807024 2.585155402102992e-09 8.587513344930876 -0.08904960004808249 S(ph)PLGSVR ddPTM_A459_Selumetinib_30min_R2 2 SPLGSVR 7 0 Q92620;J3KSA8;H3BMS7;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 1 S(1)PLGSVR;S(1)PLGSVR 113.18 0.014249 16251300.0 21070.4 19166.7 27027.0 29266.0 31617.0 21964.4 22301.9 18738.2 17455.0 26370.0 True False 19899.39151949418 20636.724259345938 25288.11224477266 25279.920313334063 27644.98980043376 24989.79672702863 23338.98254037648 18792.72505972399 20946.48773344924 25608.629582511767 0.7770580403522862 0.8058503947996826 0.9874840105478354 0.9871641210585442 1.0795185158721898 0.9758349874408845 0.9113717883722589 0.7338434491066096 0.817946453009484 1.0 14.644342430321055 -10.199565663737612 8.075563102720277 1.000001336464953 0.9032141926140232 0.07576030462794947 0.10579444851381599 0.0 0.0 0.11597264850983931 0.028127498793452832 6.315886781693306e-11 10.199565663737612 -0.09678714385092968 S(ph)PLHIKDDVLPK ddPTM_A459_Selumetinib_30min_R1 1 SPLHIKDDVLPK 12 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 S(1)PLHIKDDVLPK 66.267 0.032461000000000004 11659000.0 10272.0 18338.0 12370.0 13773.0 12773.0 13671.0 15125.0 13726.0 6934.0 12046.0 True False 10511.317614167352 16190.978434895094 10690.221943546234 11367.804101230164 11617.684405256316 13533.482152274852 13984.10907279264 13361.941891668428 11766.49156067745 13592.221437976334 0.7733333114187639 1.1911944275464714 0.7864955697144557 0.8363462994701365 0.8547303660604579 0.9956784631585411 1.0288317576787986 0.9830579903837859 0.8656783303869786 1.0 13.730493641073862 -6.771816537534409 24.954734933427872 0.9769768452866597 0.8966853434729525 0.1185373783611533 0.1163989815541883 520.0546507287117 1250606.6746916403 0.04093842864503824 0.036497445888737705 1.6911551888794582e-07 6.771816537534409 -0.08029150181370726 S(ph)PLHIKDDVLPK ddPTM_A459_Selumetinib_30min_R2 2 SPLHIKDDVLPK 12 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 S(1)PLHIKDDVLPK;S(1)PLHIKDDVLPK 68.786 0.037524 10035600.0 158184.0 142095.0 188806.0 185309.0 189538.0 159680.0 168622.0 188790.0 155111.0 180273.0 True False 149392.76654072374 152993.22959256216 176658.42751642954 160069.59452414466 165726.54194878097 181674.4705692816 176463.2571181541 189339.34764413314 186137.53416345108 175068.05008449501 0.8533411234581105 0.8739072007640535 1.0090843385253159 0.914327853922452 0.9466407026798697 1.0377363001507018 1.0079695126151558 1.0815185726507506 1.0632296074218768 1.0 17.41755629041573 -5.297267740527893 0.4356150139375922 1.0546736748879337 0.7728080783576404 0.6878693292969191 0.041547537850770616 1.9860711621064686 0.40998816469115296 0.03458613795003094 0.27749606814886557 5.043502721038304e-06 5.297267740527893 -0.2818655965302933 S(ph)PLHPMSEIPR ddPTM_A459_Selumetinib_30min_R2 2 SPLHPMSEIPR 11 0 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 S(1)PLHPMSEIPR;S(1)PLHPMSEIPR 73.877 0.037356 5588700.0 21062.0 14587.8 21179.0 23063.0 25673.0 20807.4 20559.0 20588.3 20954.2 20160.1 True False 19891.458357866304 15706.637352829992 19816.366197951662 19921.7796141059 22447.72822046796 23673.430479228904 21515.034236885644 20648.208544423444 25145.625509266232 19578.025530769635 1.0160094196732998 0.8022584978319081 1.0121738868307961 1.0175581589060658 1.1465777376369328 1.209183757678871 1.098937898669696 1.0546624587843072 1.2843800550646094 1.0 14.256947654164064 -5.871645823239183 1.8314789807476286 1.1363590892219977 0.914128496613212 0.4713912532422556 0.09125126822516014 0.2758367660367348 1.8862567307195326 0.02783206827088431 0.051034582595163205 1.3438604623207283e-06 5.871645823239183 -0.22223059260878564 S(ph)PLIESTANMDNNQSQK ddPTM_A459_Selumetinib_30min_R1 1 SPLIESTANMDNNQSQK 17 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 S(1)PLIESTANMDNNQSQK 185.63 4.5975e-14 0.0 936.89 789.27 581.53 632.03 439.25 665.44 665.71 723.51 392.91 470.97 True False 958.7177141294051 696.8619014783316 502.5614201156382 521.6578251724751 399.51991505588603 658.7462777711783 615.4949587338045 704.3201645083063 666.7395729890077 531.4235871362871 1.8040556297015389 1.3113115758251368 0.9456889612744137 0.9816233938421188 0.7517918374846739 1.2395879552900584 1.1582003012898952 1.3253460733719349 1.25462924327824 1.0 9.053718452773172 -4.833958106001993 2.9865242061978616 1.0874820202436255 1.8790278483092446 0.642099154986786 0.16354721304564285 0.23377194357326572 3.245994275745639 0.04650554653711721 0.42141533817985827 1.4656892211076958e-05 4.833958106001993 0.7915458280656191 S(ph)PLIESTANMDNNQSQK ddPTM_A459_Selumetinib_30min_R2 3 SPLIESTANMDNNQSQK 17 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 S(0.956)PLIES(0.03)T(0.013)ANMDNNQSQK;S(0.991)PLIES(0.004)T(0.006)ANMDNNQSQK;S(1)PLIESTANMDNNQSQK 216.29 1.0597000000000004e-11 33633400.0 91559.0 71082.0 96507.0 100846.0 102318.0 98918.0 114665.0 114740.0 103591.0 84805.0 True False 86470.51731971704 76533.76083534608 90297.84468887685 87110.60083094677 89463.89810547436 112543.05661179994 119997.14970438718 115073.87440377043 124312.09457437618 82356.4593001484 1.0499542847583447 0.9292988247153575 1.0964269889236744 1.0577263953695712 1.086300927282739 1.36653588034469 1.45704600129854 1.3972659264573686 1.509439522179072 1.0 16.329594185965448 -6.726313605613851 3.9511871789284743 1.3808319014335493 1.0350292002619053 0.5500974317355894 0.13546994990705216 0.14629030926637712 4.875709619886097 0.04479734326152518 0.042897773797928834 1.8779602451942176e-07 6.726313605613851 -0.345802701171644 S(ph)PLKALSEFFK ddPTM_A459_Selumetinib_30min_R1 1 SPLKALSEFFK 11 1 O75369-8 O75369-8 FLNB Filamin-B 1 S(1)PLKALSEFFK 75.566 0.029165 1856300.0 843.97 335.6 3207.2 2719.4 1951.0 1051.9 1029.2 986.61 983.08 676.21 True False 863.6328589202512 296.30779598379263 2771.6798558885607 2244.507839460197 1774.5323944770269 1041.3188410487826 951.5666153863257 960.441897839063 1668.2149586776459 763.008140343183 1.1318789581089 0.3883415920707221 3.6325691815580434 2.941656478855744 2.3257057174762044 1.3647545628811013 1.2471251158058858 1.2587570788000755 2.186365872751138 1.0 9.575554638669516 -6.76894752312162 24.89285482656683 1.4173054930958258 2.1235012936572972 0.12580774002399664 0.8834083495828937 389.6936865898321 1292000.6931995577 0.33809447655905056 0.30398180906790423 1.7023641968519465e-07 6.76894752312162 0.7061958005614715 S(ph)PLLEVK ddPTM_A459_Selumetinib_30min_R2 1 SPLLEVK 7 0 A0A140T9E6;A2AB20;Q9BW19 A0A140T9E6 KIFC1 Kinesin-like protein KIFC1 1 S(1)PLLEVK 88.177 0.03262 1874500.0 14682.0 11469.0 13932.0 15191.0 14388.0 15158.0 19353.0 16267.0 15651.0 14149.0 True False 13866.033216702752 12348.63542135258 13035.630288014669 13121.959594063337 12580.450809647999 17245.87690937607 20252.95284724199 16314.334276853173 18781.63732547773 13740.481606483096 1.009137351500141 0.8987047015532694 0.9487025754515139 0.9549854197157162 0.9155756814020429 1.2551144423670741 1.4739623709904137 1.18731895606597 1.3668834807519479 1.0 13.746144951326135 -6.784647220664579 7.081931838615195 1.283395669652229 0.9432564677284467 0.6291793567767394 0.11862148940383758 0.09832608510668156 18.935885667782276 0.03890715883262243 0.03518738239781211 1.6419229729633883e-07 6.784647220664579 -0.34013920192378233 S(ph)PLLLGAQR ddPTM_A459_Selumetinib_30min_R2 2 SPLLLGAQR 9 0 Q96DR7;Q96DR7-4;Q96DR7-3 Q96DR7 ARHGEF26 Rho guanine nucleotide exchange factor 26 1 S(1)PLLLGAQR;S(1)PLLLGAQR 99.973 0.018330000000000003 10484900.0 6705.9 8458.3 6134.2 10823.0 9938.3 7370.2 9157.0 9080.9 7222.5 9232.8 True False 6333.212923844637 9107.024412278884 5739.532250411975 9348.888729283619 8689.761904470717 8385.378149985727 9582.818644251272 9107.323915576078 8667.20181351115 8966.225074304693 0.706341060073797 1.0157033017582497 0.6401280586698924 1.0426783458822106 0.9691661577148826 0.9352183422225758 1.0687684688747783 1.0157367052580182 0.966650038526193 1.0 13.130284999699542 -5.789619127864664 24.99998684236107 0.9993143706073937 0.8102218579857475 0.4950269394716831 0.09747024775029012 175.80137168724866 155963.51675141865 0.025744476199726182 0.03819377232499834 1.6232330332684407e-06 5.789619127864664 -0.18909251262164617 S(ph)PLLNSPTVAK ddPTM_A459_Selumetinib_30min_R1 1 SPLLNSPTVAK 11 0 O43365 O43365 HOXA3 Homeobox protein Hox-A3 1 S(0.974)PLLNS(0.023)PT(0.003)VAK 105.78 0.011496 7571200.0 1211.7 1334.3 1395.7 1618.9 1259.6 1117.0 1055.1 1415.3 891.82 949.58 True False 1239.9302524422296 1178.079535700758 1206.1716060313247 1336.1895055167004 1145.6694024004426 1105.7639941548534 975.5129575341165 1377.7616464576943 1513.3534040443267 1071.4678426924756 1.157225819606893 1.0995005997943712 1.1257189044520028 1.247064496269911 1.0692522507455817 1.0320085681490874 0.9104453896467527 1.285863739032557 1.4124114077389793 1.0 10.065372836604432 -8.144374532364449 0.0034917766767167376 1.0277921363827947 1.2370855772541351 0.0007870207660671813 0.14054497170043398 1294813.8625636492 4283.3157052838515 128561.05867192106 128151.40838187827 7.171755376007469e-09 8.144374532364449 0.2092934408713405 S(ph)PLPAGPSSCTSPR ddPTM_A459_Selumetinib_30min_R1 2 SPLPAGPSSCTSPR 14 0 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(1)PLPAGPSSCTSPR;S(1)PLPAGPSSCTSPR 201.3 6.0184e-05 77274000.0 1181.9 1140.51 1102.42 1113.47 1364.83 1178.19 1517.73 1411.9099999999999 798.87 980.6499999999999 True False 1209.4359704229362 1006.9785589912852 952.7174191595986 919.0233669205504 1241.3813674803073 1166.338478310929 1403.2464041685676 1374.4615602699662 1355.624042843726 1106.525979839904 1.093002778477846 0.910036074468833 0.8609986900600752 0.8305483862688139 1.1218727712655374 1.0540543101208333 1.2681549549985207 1.2421412468497377 1.2251172295474368 1.0 10.111821608865798 -6.612854197905123 1.9093099706364574 1.1922374802246198 0.9217909760304014 0.51591129360104 0.1048403850185431 0.2482866005895334 1.8495298847998776 0.040416107953531934 0.04115975155685123 2.4386293818316566e-07 6.612854197905123 -0.27044650419421845 S(ph)PLPAGPSSCTSPR ddPTM_A459_Selumetinib_30min_R2 4 SPLPAGPSSCTSPR 14 0 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(1)PLPAGPSSCTSPR;S(1)PLPAGPSSCTSPR;S(1)PLPAGPSSCTSPR;S(1)PLPAGPSSCTSPR 162.88 0.00027233 114480000.0 24945.3 23970.7 30414.5 28771.2 39778.9 30361.1 29067.5 32504.4 18587.2 31082.2 True False 23558.94008994789 25809.175612051284 28457.664182803783 24852.51292691165 34781.518954121966 34543.06593437514 30419.196346158544 32598.982422606896 22305.159369760375 30184.776124745826 0.7804908008124666 0.855039490946982 0.9427820191607736 0.8233459418152609 1.1522867955150304 1.1443870178668092 1.007766173929663 1.0799809244197731 0.7389539441200079 1.0 14.881533480520636 -6.241789131533928 24.896007013625212 1.030112939915562 0.8573425776882744 0.34411994509982036 0.11446341965572493 928.3700227614585 1176203.9826931201 0.03443689585401984 0.04439135929070642 5.730742153820064e-07 6.241789131533928 -0.1727703622272876 S(ph)PLPAPPRPFLYR ddPTM_A459_Selumetinib_30min_R1 1 SPLPAPPRPFLYR 13 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.561)PLPAPPRPFLY(0.439)R 75.764 0.025564 75007000.0 490.13 680.07 436.78 495.05 509.99 520.06 621.36 486.57 445.57 387.32 True False 501.54907537303814 600.4470882440347 377.46767506080243 408.59881073941693 463.86149454604777 514.8286685766993 574.4903149401939 473.6645829978948 756.0997468547814 437.03629481628695 1.1476142401030327 1.3739066877647754 0.8636986894177179 0.9349310699954015 1.0613797985383275 1.177999801579668 1.3145139700163513 1.0838106322428094 1.7300616809700355 1.0 8.771609286839553 -7.016098535280937 2.935543635996515 1.28954334386761 1.0735797182840354 0.16267879822264286 0.21920937117947795 0.49657947432078575 8.66659766683714 0.08810443621148473 0.07039999474565949 9.636103692440911e-08 7.016098535280937 -0.21596362558357463 S(ph)PLPAPPRPFLYR ddPTM_A459_Selumetinib_30min_R2 1 SPLPAPPRPFLYR 13 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.98)PLPAPPRPFLY(0.02)R 86.738 0.014336000000000003 74163000.0 11421.0 12950.0 11451.0 15431.0 17388.0 11657.0 10451.0 13207.0 12572.0 9713.4 True False 10786.26654188544 13943.22335918701 10714.25512690612 13329.27118004024 15203.563989307722 13262.645938289814 10936.992208263626 13245.430183463457 15086.751291029725 9432.94890355593 1.1434670803548348 1.478140452338382 1.1358330503483567 1.4130545300648787 1.6117509110620165 1.4059914957548647 1.1594457173557589 1.4041664297015686 1.5993674348583065 1.0 13.203493137584958 -4.7419143079170345 24.151922082398045 1.3672966166760165 1.1434659171761805 0.098804493318281 0.19040372856746288 2079.7145392520024 2572336.405644938 0.04621060526471248 1.631255162345725 1.8116975293962857e-05 4.7419143079170345 -0.22383069949983603 S(ph)PLPGPSEEK ddPTM_A459_Selumetinib_30min_R2 2 SPLPGPSEEK 10 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 S(1)PLPGPSEEK;S(1)PLPGPSEEK 105.2 0.012654 49562000.0 108405.0 86289.0 88473.0 112852.0 108137.0 88212.0 127820.0 124394.0 107188.0 100010.0 True False 102380.28407959812 92907.08883713427 82780.74350211883 97481.36291944156 94551.86330295418 100362.40229119154 133763.8832705249 124755.96594546468 128628.59508295335 97122.45144281402 1.054136119493235 0.9565974443287012 0.8523337526221768 1.003695453227299 0.9735325035388608 1.0333594426442707 1.377270458924582 1.2845224156941852 1.3243960914504946 1.0 16.56751721629704 -7.114070635535722 4.813390059276439 1.268792736758005 0.9662482576306153 0.6102576097853991 0.10502846801194711 0.1382884039495188 4.909116090369923 0.03934272281854936 0.030358922427892183 7.690053557526658e-08 7.114070635535722 -0.3025444791273897 S(ph)PLQSQPHSR ddPTM_A459_Selumetinib_30min_R2 2 SPLQSQPHSR 10 0 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2 Q9UI08-4 EVL Ena/VASP-like protein 1 S(0.999)PLQS(0.001)QPHSR;S(0.992)PLQS(0.008)QPHSR 115.12 0.0044635 6488700.0 18746.6 19401.4 22658.5 23769.6 19586.9 17800.7 18228.2 19729.2 20956.3 21778.2 True False 17704.73902058572 20889.42499466649 21200.67677870948 20532.139475152904 17126.2185128923 20252.584846333997 19075.847418493075 19786.608705655115 25148.145567945136 21149.406779440953 0.8371269797409283 0.9877073722452022 1.0024241814346473 0.9708139660499563 0.8097729970157111 0.9575958823592753 0.9019566183310845 0.9355632955572732 1.189070966869449 1.0 14.368329577251115 -8.192489499046786 9.33250881386131 1.094177968548357 0.9277832173349104 0.4649684745692184 0.0725544547043169 0.3503044030750801 45.48535244539089 0.048173103025471585 0.018127104086172036 6.419637435789313e-09 8.192489499046786 -0.1663947512134466 S(ph)PLQSVVVR ddPTM_A459_Selumetinib_30min_R2 2 SPLQSVVVR 9 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(1)PLQSVVVR;S(1)PLQSVVVR 150.09 0.0013571 30552000.0 7943.0 5762.2 12657.1 8130.3 8374.099999999999 12069.0 10458.0 7861.2 4728.5 7185.5 True False 7501.559858348308 6204.142211606753 11842.755966008504 7022.939114450208 7322.070692596139 13731.395198526185 10944.317722133866 7884.074790508283 5674.3321253288295 6978.035944828909 1.0750245366545235 0.889095765722495 1.6971474580586832 1.006434929538386 1.0493025187154816 1.9678023024088704 1.5683951485294627 1.1298415274502556 0.8131703777670861 1.0 12.768605313735339 S(ph)PLSALAR ddPTM_A459_Selumetinib_30min_R1 3 SPLSALAR 8 0 Q9BQG0;Q9BQG0-2;I3L1L3;I3L2H8 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 S(1)PLSALAR;S(0.999)PLS(0.001)ALAR;S(1)PLSALAR 137.05 0.0025561 44767100.0 3397.5 4666.0 3145.67 3419.5000000000005 3544.5 2867.97 3911.1000000000004 3648.1000000000004 1592.28 3230.6000000000004 True False 3476.6551396158106 4119.702550835448 2718.505291928461 2822.348516964826 3223.900600832303 2839.120825708413 3616.0825781553276 3551.34053730115 2701.982864470074 3645.27897870881 0.9537418562261242 1.1301473974687894 0.745760559838243 0.7742476044904872 0.8844043541419804 0.7788487087795005 0.9919906265819403 0.9742301091476588 0.7412280048390536 1.0 11.83181351507111 -5.256466126863117 24.99995895594518 0.8598518321956029 1.0419446251881879 0.32710299856816727 0.10359772495883603 468.0859895669322 2352992.9900100613 0.02654012580400901 0.06575802181541808 5.540307543143075e-06 5.256466126863117 0.18209279299258496 S(ph)PLSALAR ddPTM_A459_Selumetinib_30min_R2 5 SPLSALAR 8 0 Q9BQG0;Q9BQG0-2;I3L1L3;I3L2H8 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 S(1)PLSALAR;S(1)PLSALAR;S(1)PLSALAR;S(1)PLSALAR;S(1)PLSALAR 125.71 0.0050199 73158400.0 30347.0 24358.9 39415.4 44283.3 42197.899999999994 31244.399999999998 27825.899999999998 35133.0 38047.899999999994 31178.699999999997 True False 28660.43522866627 26227.149303791553 36879.45607624271 38251.83814704661 36896.622547987565 35548.03249157604 29119.859485974815 35235.23121341875 45658.543147149954 30278.489919008713 0.9465609185045045 0.8661974019822651 1.2180084335411305 1.2633337477980453 1.2185753862455344 1.1740358448080706 0.9617342068203172 1.1637050364026977 1.5079531135562247 1.0 14.88600563504869 -5.262862371671003 24.990033305415835 1.1894079169173601 0.9063791434721997 0.3883519612035108 0.14157739091940602 120.55032298608819 2117104.310976405 0.03718964848274083 0.08482716811929751 5.459308396768567e-06 5.262862371671003 -0.2830287734451604 S(ph)PLSGIPVR ddPTM_A459_Selumetinib_30min_R1 1 SPLSGIPVR 9 0 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 S(0.993)PLS(0.007)GIPVR 92.239 0.030221 0.0 849.99 909.12 844.08 956.97 841.86 807.07 851.01 701.92 477.88 777.27 True False 869.7931132073702 802.6798077615779 729.458572199556 789.8531540517115 765.7139116424547 798.9516085609288 786.8176305479178 683.3028014425099 810.9274570257489 877.0401757509429 0.9917369092728647 0.9152144108726878 0.8317276589695289 0.9005894779853388 0.8730659470494975 0.9109635232808431 0.8971283782686758 0.7791009127460433 0.924618369200035 1.0 9.77649912141745 -4.8399193711163315 3.584250237051597 0.8821166090257824 0.9977764520867971 0.2255718108498047 0.055186785680140404 0.3227442346286803 6.944285365800655 0.013117247813758073 0.09064449913315063 1.4457081485843528e-05 4.8399193711163315 0.11565984306101473 S(ph)PLSGIPVR ddPTM_A459_Selumetinib_30min_R2 2 SPLSGIPVR 9 0 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 S(1)PLSGIPVR;S(0.999)PLS(0.001)GIPVR 123.11 0.005730600000000001 99026000.0 53516.0 51940.0 51631.0 56985.0 53699.0 39233.0 43590.0 41505.0 40441.0 51996.0 True False 50541.794961521875 55923.6309865771 48309.11767158236 49223.544695391945 46952.851544849036 44636.989628285526 45617.02137194636 41625.772678477355 48530.330015950756 50494.740378167706 1.0009318709830324 1.10751398200587 0.9567158343578623 0.9748251862816709 0.9298562819257494 0.8839928533939966 0.9034014439981096 0.824358584017495 0.9610967330952691 1.0 15.623845501562158 -5.754565249634 1.2586523584121974 0.9045650731576593 1.054127290859982 0.4509821526041521 0.054057843947646164 0.3817571096984998 1.1923225711902594 0.018017029260806283 0.046677473695661505 1.7596842639881057e-06 5.754565249634 0.1495622177023226 S(ph)PLSPTETFSWPDVR ddPTM_A459_Selumetinib_30min_R1 5 SPLSPTETFSWPDVR 15 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(1)PLSPTETFSWPDVR;S(1)PLSPTETFSWPDVR;S(1)PLSPTETFSWPDVR;S(0.976)PLS(0.019)PT(0.004)ETFSWPDVR;S(1)PLSPTETFSWPDVR 205.26 3.8405e-06 76818300.0 3563.1699999999996 3418.36 4193.48 4061.7900000000004 4229.36 3530.8199999999997 4166.46 4439.4 1909.11 2824.7200000000003 True False 3646.184928278106 3018.1368220475515 3624.0284491368034 3352.474625741355 3846.8151347541548 3495.303156528058 3852.1805677638117 4321.6526907965 3239.620234122432 3187.3003271028156 1.1439728152609974 0.9469257717520991 1.1370213275229586 1.0518226341063628 1.2069195682763987 1.0966343920609483 1.2086029468284707 1.3558975456588946 1.0164151167603255 1.0 11.638119249811131 -6.251128821644358 23.440962825230763 1.165727179915814 1.0659410412037367 0.09335682389831512 0.10942515787755926 568.0527843616048 1291459.1287746264 0.031333058409962256 0.03992918197372241 5.608815810915195e-07 6.251128821644358 -0.09978613871207731 S(ph)PLSPTETFSWPDVR ddPTM_A459_Selumetinib_30min_R2 6 SPLSPTETFSWPDVR 15 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(1)PLSPTETFSWPDVR;S(1)PLSPTETFSWPDVR;S(1)PLSPTETFSWPDVR;S(0.983)PLS(0.016)PTETFSWPDVR;S(1)PLSPTETFSWPDVR;S(0.916)PLS(0.083)PT(0.001)ETFSWPDVR 176.43 1.9283e-05 32306500.0 21232.8 20180.5 27021.5 26812.8 33710.799999999996 19373.0 22608.9 22241.300000000003 16582.699999999997 24063.3 True False 20052.76597763289 21728.27945946515 25282.9661087847 23160.850385340087 29475.74792562424 22041.454899415676 23660.258648685452 22306.018500754573 19899.703359350813 23368.530005038127 0.8581098585708911 0.9298094255300035 1.0819236855434995 0.991112850502224 1.2613436925330532 0.9432110147563265 1.0124838251950137 0.9545323773444679 0.851559912200748 1.0 14.512279363942197 -10.219902539953189 8.393102079113348 1.0000021135518729 0.9949022587627433 0.0 0.11255452700147166 0.0 0.0 0.11223728309761091 0.027221539608458918 6.026948216753151e-11 10.219902539953189 -0.005099854789129554 S(ph)PLSSILFSALDSDTR ddPTM_A459_Selumetinib_30min_R2 2 SPLSSILFSALDSDTR 16 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;A0A1W2PRR3;I3L233;A0A1W2PPV8 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 S(1)PLSSILFSALDSDTR;S(0.998)PLS(0.002)SILFSALDSDTR 276.34 9.5489e-52 16108900.0 6237.9 1992.02 5673.8 5897.0 4775.4 4420.88 5430.2 5931.9 2256.7 1787.5 True False 5891.222490292199 2144.8015286461555 5308.753885166353 5093.818427107594 4175.471559382339 5029.816091247035 5682.715059737169 5949.16084692109 2708.1030574663355 1735.8902305172467 3.3937759350928425 1.2355628777328074 3.0582313281321327 2.934412751196704 2.4053776477203663 2.897542714868722 3.273660373123869 3.427152674940976 1.5600658439441741 1.0 10.761460006122247 -6.675564308924599 15.807837334546823 2.6378775629046696 2.57291418890944 0.0 0.882927569159215 34.2313114213134 6233.904487326594 0.28288218657343667 0.28287537037650845 2.1107446204184688e-07 6.675564308924599 -0.06496337399522956 S(ph)PLTATPTFVTDSESTR ddPTM_A459_Selumetinib_30min_R2 1 SPLTATPTFVTDSESTR 17 0 A0A087WUK4;P13056-2;P13056-3;P13056 A0A087WUK4 NR2C1 Nuclear receptor subfamily 2 group C member 1 1 S(0.997)PLT(0.003)ATPTFVTDSESTR 71.781 0.028913 2844200.0 3255.7 3955.7 1985.7 5778.7 4626.1 1533.1 3876.7 3442.6 1265.5 3116.4 True False 3074.7612275997208 4259.089470419776 1857.9422238666907 4991.631091186479 4044.927960141271 1744.270608903844 4056.974231535316 3452.617396046889 1518.6353610243489 3026.4214346203885 1.0159725913999798 1.4073021759951962 0.6139073040565274 1.6493509575650331 1.3365382341896597 0.5763475598442661 1.340518602308998 1.1408250538246534 0.5017924283948363 1.0 11.563397184081333 S(ph)PLTGYVR ddPTM_A459_Selumetinib_30min_R1 3 SPLTGYVR 8 0 H0YNS8;H0YKM5;Q9NP66 H0YNS8 HMG20A High mobility group protein 20A 1 S(0.997)PLT(0.003)GYVR;S(1)PLTGYVR;S(0.999)PLT(0.001)GYVR 128.28 0.0043687 119659000.0 1912.2600000000002 2162.17 1797.13 1596.98 1731.69 1742.81 2055.9 1915.58 1024.55 1910.67 True False 1956.811937389766 1909.0221312344365 1553.0896169284747 1318.0974220273392 1575.0589452547006 1725.2789137448701 1900.8218077854142 1864.7725957192324 1738.5865198286815 2155.923106001847 0.90764458711084 0.8854778382030111 0.720382657713927 0.6113842457358079 0.7305728765881835 0.8002506717154653 0.8816742130059001 0.8649532028892476 0.8064232508982592 1.0 11.074090007943552 -7.139699542402299 3.6397702840935926 0.8772143439788211 0.7657233203438762 0.268984602812515 0.09056544400658809 0.4038316383238819 9.647072550097503 0.040475683454872284 0.03063580602637068 7.24937319422744e-08 7.139699542402299 -0.1114910236349449 S(ph)PLTGYVR ddPTM_A459_Selumetinib_30min_R2 3 SPLTGYVR 8 0 H0YNS8;H0YKM5;Q9NP66 H0YNS8 HMG20A High mobility group protein 20A 1 S(0.999)PLT(0.001)GYVR;S(1)PLTGYVR;S(1)PLTGYVR 114.86 0.010127 191951000.0 32371.1 25384.8 42455.7 44940.0 43656.8 36102.9 41112.2 38969.8 32381.2 31673.6 True False 30572.043853780575 27331.732535003113 39724.14648427106 38819.094474175916 38172.24248725611 41075.74676550425 43023.99876227884 39083.19566620234 38858.344806322886 30759.100870104103 0.9939186448552748 0.8885738451987011 1.2914599374028002 1.2620360600951641 1.24100644711488 1.3354014130311356 1.3987404555149219 1.270622175571742 1.263312115995261 1.0 14.908725711548774 -5.265213491502045 24.97019815743855 1.2748408070302648 0.9412462299831008 0.6081188596932747 0.10091609559092207 168.41327506570562 1114260.6219800385 0.02489684829604673 0.05521263851011708 5.429833448461286e-06 5.265213491502045 -0.333594577047164 S(ph)PLTQEQLIPNLAMK ddPTM_A459_Selumetinib_30min_R1 2 SPLTQEQLIPNLAMK 15 0 Q9UNE7;H3BTA3;Q9UNE7-2 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 S(0.999)PLT(0.001)QEQLIPNLAMK;S(1)PLTQEQLIPNLAMK 177.04 3.2193e-09 7122800.0 4528.9 5320.8 5149.0 4924.84 4586.9800000000005 4341.08 5065.7 4680.44 2888.09 4710.5 True False 4634.414558294642 4697.83826242719 4449.794081432465 4064.809144696317 4172.088468897095 4297.412676585276 4683.590170581534 4556.299526988235 4900.877792252227 5315.138559155534 0.8719273273340508 0.8838599803451934 0.8371924893223189 0.7647607112131677 0.7849444417042543 0.8085231699525152 0.8811793179904722 0.8572306208536805 0.922060213051318 1.0 12.375891586202282 -8.439062325413916 1.0572456577345024 0.9992420095171812 0.8267685705375748 0.6860956686367021 0.03651644621074221 0.33543957904426075 0.8196020503883603 0.03966703582497887 0.01307235051045222 3.6386281458445582e-09 8.439062325413916 -0.17247343897960643 S(ph)PLTQEQLIPNLAMK ddPTM_A459_Selumetinib_30min_R2 1 SPLTQEQLIPNLAMK 15 0 Q9UNE7;H3BTA3;Q9UNE7-2 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 S(0.998)PLT(0.002)QEQLIPNLAMK 205.28 3.7665e-06 5780200.0 25780.0 20706.0 22970.0 27664.0 27014.0 23966.0 23360.0 22970.0 24588.0 23624.0 True False 24347.25080551674 22294.083619716315 21492.135207845036 23896.11547693819 23620.25981177587 27267.09895831292 24446.28628696185 23036.838897111797 29506.287046121422 22941.913737476614 1.0612563138420508 0.9717621587643737 0.9368065564964922 1.0415920725001613 1.0295679812094816 1.1885276559893487 1.0655731063545837 1.0041376303965488 1.2861301539078502 1.0 14.485698120703088 -6.417655756064448 2.6019550904679534 1.1059986949476637 0.9937506682980722 0.24611107056270654 0.08622274815935435 0.39761698136730345 5.258282864847655 0.028493621175491236 0.032528922603247704 3.822471393494873e-07 6.417655756064448 -0.11224802664959144 S(ph)PMCNQPSINK ddPTM_A459_Selumetinib_30min_R2 2 SPMCNQPSINK 11 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;Q08499-3;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9 A0A1B0GW84;Q08499-6;Q08499-9 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 S(1)PMCNQPSINK;S(1)PMCNQPSINK 131.52 0.0034709000000000003 0.0 19097.9 17965.6 29028.0 25645.0 31216.0 19541.4 18441.1 21554.8 21383.0 21096.0 True False 18036.515172951043 19343.503751491127 27160.370083296708 22152.106759907467 27294.367005419244 22233.050470832688 19298.64769034642 21617.520899410763 25660.197490939256 20486.90366600942 0.8803924432405124 0.9441887396378326 1.3257430466839888 1.0812813454412267 1.332283660351483 1.0852323432222881 0.9419992403422837 1.0551873163379584 1.2525171157764088 1.0 14.322414335433693 -5.038493016319621 15.479995039650495 1.132960379250416 0.8963314321591752 0.3398590751718191 0.12513382885761026 6.1635808726327905 2479.895341366704 0.03239012193072457 0.08614269211072346 9.15180975747411e-06 5.038493016319621 -0.23662894709124072 S(ph)PMDSLLHPR ddPTM_A459_Selumetinib_30min_R1 2 SPMDSLLHPR 10 0 E9PAK5;O75064 E9PAK5 DENND4B DENN domain-containing protein 4B 1 S(1)PMDSLLHPR;S(1)PMDSLLHPR 165.58 0.00023293 2162800.0 929.37 1417.62 1455.15 1341.65 1641.43 1325.37 1608.15 1338.69 670.1800000000001 1161.26 True False 951.022512760778 1251.6443913663425 1257.548622566799 1107.3560133896347 1492.9629463180047 1312.0379811396763 1486.8459507710065 1303.1835925220462 1137.246511989445 1310.3190326302838 0.7257946264061601 0.9552211027980261 0.959727052153432 0.8451041203047863 1.1393888886137054 1.0013118549502726 1.134720563271045 0.9945544253494402 0.8679157393498134 1.0 10.355702402346065 -4.000373944323994 0.8832429142242331 1.0105808961958191 3.947681299168812e-14 0.4361872601629181 0.09001343581125623 7.506310187866039 1.6808345084402658 0.03138170951298999 10.193373260991521 9.991393319613489e-05 4.000373944323994 -1.0105808961957796 S(ph)PMDSLLHPR ddPTM_A459_Selumetinib_30min_R2 1 SPMDSLLHPR 10 0 E9PAK5;O75064 E9PAK5 DENND4B DENN domain-containing protein 4B 1 S(1)PMDSLLHPR 112.5 0.0054251 1556900.0 24396.0 30779.0 35318.0 19407.0 29329.0 47176.0 23358.0 21221.0 20834.0 30748.0 True False 23040.167984925756 33139.65032991636 33045.678331330906 16763.733121057667 25644.428815413274 53674.065778910524 24444.19328299892 21282.749596674334 25001.382150597623 29860.225347101707 0.7716006063953593 1.109825861817649 1.1066787992120222 0.5614067853203522 0.8588156491559221 1.7975104057317584 0.8186205227473785 0.7127457796878308 0.8372804243764459 1.0 14.865937432695024 S(ph)PMQEEEDLAAGVGR ddPTM_A459_Selumetinib_30min_R2 2 SPMQEEEDLAAGVGR 15 0 Q92560;F8W6N3 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 S(1)PMQEEEDLAAGVGR;S(1)PMQEEEDLAAGVGR 150.49 0.00026489999999999993 7686500.0 8582.6 6096.9 6368.799999999999 8865.900000000001 8235.9 6174.6 6298.1 8103.5 7135.5 5665.299999999999 True False 8105.613450869971 6564.512625376627 5959.038341825141 7658.349125469433 7201.232612119818 7025.09510256192 6590.974129448392 8127.079843393359 8562.799382528046 5501.7280687828525 1.4732850023725683 1.1931728619275241 1.0831212061601327 1.3919897584403311 1.308903770249944 1.2768888274254677 1.1979825333145762 1.4771867569222323 1.5563836081092235 1.0 12.425669118697593 -7.756297939486286 24.960389008887727 1.3875888840086976 1.270388787117038 0.014987419284919978 0.170440036320078 309.29664769597264 1501580.530482509 0.08018116772282455 0.0444915714763341 1.7526776980401197e-08 7.756297939486286 -0.11720009689165956 S(ph)PMSTNSSVHTGS(ph)DVEQDAEK ddPTM_A459_Selumetinib_30min_R2 2 SPMSTNSSVHTGSDVEQDAEK 21 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 2 S(0.477)PMS(0.02)T(0.024)NS(0.11)S(0.37)VHT(0.065)GS(0.934)DVEQDAEK;S(0.942)PMS(0.033)T(0.01)NS(0.013)S(0.002)VHT(0.042)GS(0.958)DVEQDAEK 90.757 0.0028457 11777300.0 29686.0 24814.0 36216.0 51352.0 36028.0 26070.0 27519.9 24724.0 24032.1 38975.0 True False 28036.170962473625 26717.154010414415 33885.901988999365 44357.76901285893 31501.840545593415 29660.905860102535 28799.62987964734 24795.94274672145 28839.191512977653 37849.69048078862 0.7407239162683235 0.7058750988723476 0.8952755374895033 1.1719453567361038 0.83228793011089 0.7836498920686692 0.7608947263192332 0.6551161299273276 0.7619399563548762 1.0 15.207993882041642 -6.660268733245497 4.5810004590804 0.7688979723546665 0.8816767643141157 0.06003003349099045 0.1423592964790227 0.5200777675381661 18.798628928572494 0.051541678134568544 0.0510683661846263 2.186408297012775e-07 6.660268733245497 0.11277879195944918 S(ph)PNELVDDLFK ddPTM_A459_Selumetinib_30min_R2 8 SPNELVDDLFK 11 0 Q9UNZ2-4;Q9UNZ2;Q9UNZ2-5;F2Z2K0 Q9UNZ2-4 NSFL1C NSFL1 cofactor p47 1 S(1)PNELVDDLFK;S(1)PNELVDDLFK;S(1)PNELVDDLFK;S(1)PNELVDDLFK;S(1)PNELVDDLFK;S(1)PNELVDDLFK;S(1)PNELVDDLFK;S(1)PNELVDDLFK 150.12 0.00061911 3198690.0 48710.47 38969.909999999996 48473.12 53197.30999999999 47195.76 32766.27 37280.759999999995 35381.53 31034.28 44102.87 True False 46003.337080861114 41958.77678898963 45354.412232742594 45951.74460752166 41266.606693352296 37279.52626991569 39014.38921042449 35484.48439457239 37242.00317023367 42829.50555008231 1.074103856442319 0.9796698852833008 1.0589525059939768 1.0728992552526293 0.9635088279293244 0.8704169191568929 0.9109231757252801 0.8285055813469273 0.8695408151907115 1.0 15.386317401523634 -6.527701725197294 3.519466686777124 0.8866013771953104 1.0418229324898964 0.6756463314658188 0.048787244062615226 0.1312328616554437 3.4797528430869873 0.01597767262016282 0.016905146187148404 2.9668683443695195e-07 6.527701725197294 0.15522155529458603 S(ph)PNQSLR ddPTM_A459_Selumetinib_30min_R2 1 SPNQSLR 7 0 Q96B01-3;Q96B01-2;Q96B01 Q96B01-3 RAD51AP1 RAD51-associated protein 1 1 S(1)PNQSLR 99.53 0.021153 9968300.0 13331.0 4474.5 3679.4 10744.0 9282.0 9081.1 13160.0 14370.0 8795.8 11436.0 True False 12590.116388221244 4817.679762214851 3442.671409827821 9280.648665566227 8115.9121778671615 10331.939094981864 13771.966076045284 14411.814320918444 10555.205775186063 11105.812965703633 1.1336510372632203 0.4337980278519499 0.30998823953359306 0.8356568487355424 0.7307805563564126 0.9303181250115049 1.2400682524165605 1.2976820666280104 0.9504217122854558 1.0 13.439027384200232 -6.840599590055646 1.9595662904953157 1.1461756857361538 0.6421970611098194 0.4361819851599812 0.2299932410481812 0.29283205013580343 2.309987434770424 0.09779109875304613 0.08485355641163557 1.4434455632263807e-07 6.840599590055646 -0.5039786246263344 S(ph)PNREWEVLQPAPHQVITNLPEGVR ddPTM_A459_Selumetinib_30min_R2 4 SPNREWEVLQPAPHQVITNLPEGVR 25 1 O75376-2;O75376;A0A088AWL3 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 S(1)PNREWEVLQPAPHQVITNLPEGVR;S(1)PNREWEVLQPAPHQVITNLPEGVR;S(0.999)PNREWEVLQPAPHQVIT(0.001)NLPEGVR;S(1)PNREWEVLQPAPHQVITNLPEGVR 92.392 1.5636e-05 20850100.0 21590.399999999998 16738.97 18605.98 21032.6 25509.7 17530.2 21927.699999999997 22008.6 19087.0 18327.55 True False 20390.492001219107 18022.795174728246 17408.891503459323 18167.92359674125 22304.943426388494 19944.82592668853 22947.381498913248 22072.64138228014 22904.933335339192 17798.386010806364 1.1456371374819567 1.0126083996484643 0.9781163018314943 1.0207624211381032 1.2532003414717467 1.120597447126888 1.2892956409070266 1.2401484813779544 1.2869106963649606 1.0 14.119458800528847 -6.25540340981233 24.426229481617856 1.2110249712514516 1.0330069499447463 0.41659091023182093 0.09137020080932187 315.35553143193744 1276172.116093327 0.026268624252759155 0.03302200788878924 5.553881256614507e-07 6.25540340981233 -0.1780180213067053 S(ph)PNSHDSEPWTLLR ddPTM_A459_Selumetinib_30min_R1 2 SPNSHDSEPWTLLR 14 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 S(0.999)PNS(0.001)HDSEPWTLLR;S(0.995)PNS(0.005)HDSEPWTLLR 125.84 0.00089076 10159400.0 3105.0 3894.2 3134.0 3787.3999999999996 4102.0 3867.0 4369.1 3732.3999999999996 1859.48 2770.0 True False 3177.3404587217333 3438.2652536355345 2708.4200138297406 3126.0016883031376 3730.974824266921 3828.1014909550768 4039.535269417408 3633.404627456157 3155.401748954211 3125.556482084878 1.016567922203189 1.1000489907455029 0.8665400959329681 1.0001424406248332 1.193699376623712 1.2247743763061263 1.2924211392663323 1.1624824725715794 1.0095487850052944 1.0 11.60989735842742 -6.2536091343173625 21.754166682188526 1.1664228270498649 0.9940347304082061 0.34434318665401975 0.10019231391739723 107.08986929577686 297516.1052056035 0.030635101373591572 0.03866013121957189 5.57687442667209e-07 6.2536091343173625 -0.17238809664165877 S(ph)PNSHDSEPWTLLR ddPTM_A459_Selumetinib_30min_R2 2 SPNSHDSEPWTLLR 14 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 S(0.998)PNS(0.002)HDSEPWTLLR;S(0.999)PNS(0.001)HDSEPWTLLR 201.09 4.1427e-05 8314600.0 11635.0 11450.2 19788.0 28280.0 33230.0 22864.0 16986.4 20685.4 25513.0 26410.0 True False 10988.373278595314 12328.393521804104 18514.861623545396 24428.21521427892 29055.350320030793 26013.3084612729 17776.301257913055 20745.591089347694 30616.31289278088 25647.474678579292 0.4284388001666603 0.4806864487169471 0.7218980369638093 0.9524608375841893 1.1328737306171415 1.0142639299688694 0.6931014254108916 0.8088746104377427 1.193735963344241 1.0 14.646529160623588 -5.464831833990312 2.2653502999222748 0.960533845790249 0.43877831767270026 0.6993018215709597 0.13592626889877843 0.18970995614632657 1.8873902034534202 0.041970086447048804 0.10934447297880923 3.429005376052437e-06 5.464831833990312 -0.5217555281175488 S(ph)PPACSSSSSSLFSAVVAR ddPTM_A459_Selumetinib_30min_R2 2 SPPACSSSSSSLFSAVVAR 19 0 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 S(1)PPACSSSSSSLFSAVVAR;S(1)PPACSSSSSSLFSAVVAR 110.34 0.00065972 9863700.0 13915.1 12043.8 12684.2 11913.4 14590.2 8604.12 10253.1 13568.0 11730.2 14832.3 True False 13141.7544485588 12967.520733079276 11868.112381512758 10290.7743682387 12757.248637957058 9789.259429575206 10729.889466132214 13607.48063369668 14076.567769172503 14404.05296005648 0.9123650464908641 0.9002688874471084 0.8239425677220101 0.7144360269137993 0.8856707673412383 0.6796184002323205 0.7449215506140531 0.9446980423795472 0.9772643719241995 1.0 13.814187188624492 -7.88587346063121 5.568451116025451 0.9795093143492992 0.8076139175039428 0.5118151416585585 0.07453180862743257 0.18342131075580445 8.122277599083 0.04503640236580018 0.021143196536125966 1.300548460600759e-08 7.88587346063121 -0.17189539684535637 S(ph)PPADAIPK ddPTM_A459_Selumetinib_30min_R1 3 SPPADAIPK 9 0 P18754-2;M0R1Q8;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4;C9JW69;P18754 P18754-2 RCC1 Regulator of chromosome condensation 1 S(1)PPADAIPK;S(1)PPADAIPK;S(1)PPADAIPK 93.442 0.024562 170923000.0 16263.3 11829.4 13044.8 13780.900000000001 13009.699999999999 10901.900000000001 11872.2 11714.2 7229.2 10122.5 True False 16642.203247126945 10444.408348661134 11273.387809957308 11374.324514531525 11832.974932049088 10792.23678413322 10976.670395636944 11403.501362915791 12267.42440012251 11421.821476499708 1.4570533501480585 0.914425809416686 0.9870043786932058 0.9958415597664604 1.0359971880487997 0.9448787836807069 0.9610262617237838 0.9983960427308717 1.0740339818270337 1.0 13.47950512005469 -4.755828590859352 24.99999967444877 0.9893111216963918 1.4570540946281714 0.9160205156974919 0.04240806347218986 47.30121981419095 210738.33377952225 0.010646238493373667 0.09115523316507997 1.7545728672692025e-05 4.755828590859352 0.4677429729317796 S(ph)PPADAIPK ddPTM_A459_Selumetinib_30min_R2 2 SPPADAIPK 9 0 P18754-2;M0R1Q8;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4;C9JW69;P18754 P18754-2 RCC1 Regulator of chromosome condensation 1 S(1)PPADAIPK;S(1)PPADAIPK 95.483 0.022335 96195800.0 183147.0 143699.0 197051.0 201000.0 207757.0 154679.0 172867.0 177679.0 147772.0 160567.0 True False 172968.42293553046 154720.2512348891 184372.95319290683 173623.4532556603 181656.70828885442 175984.6282138396 180905.65802946212 178196.01647365806 177330.52909465868 155931.01350683224 1.10926248118019 0.9922352696573085 1.1824007876715839 1.1134632511578773 1.164981258079843 1.1286056843729082 1.1601647033579732 1.142787521648798 1.1372370711031696 1.0 17.25054837221392 -5.2662942639600105 24.99550695555307 1.1356758297725715 1.0507488756853098 0.2404091235730127 0.05430815237938969 422.2508972309713 2173980.045248086 0.012781988269268515 0.027967040695711733 5.416337724342325e-06 5.2662942639600105 -0.0849269540872617 S(ph)PPAPGLQPMR ddPTM_A459_Selumetinib_30min_R1 4 SPPAPGLQPMR 11 0 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 S(1)PPAPGLQPMR;S(1)PPAPGLQPMR;S(1)PPAPGLQPMR;S(1)PPAPGLQPMR 146.16 0.0006889999999999999 268682000.0 676.6999999999999 1036.07 1048.3 1155.9099999999999 1211.35 1146.94 1229.4 1042.8500000000001 467.233 850.72 True False 692.4657933710131 914.7664427441247 905.9466178997178 954.0520176180177 1101.7836063812128 1135.4028249381993 1136.6653682043814 1015.1902303457978 792.8602756518616 959.91819871453 0.7213800033152048 0.952962912849376 0.9437748123880889 0.9938888739640857 1.1477890593767899 1.1828120630056485 1.18412732431424 1.0575799393170011 0.8259665008056069 1.0 9.906767658798985 -4.288541307291383 0.8568652583987243 1.0722931891377236 0.201212204655863 0.4742263076000869 0.1040206216348628 4.42493169010973 1.402320067951123 0.0393719709009599 4.4354322579308585 5.1458686050120556e-05 4.288541307291383 -0.8710809844818607 S(ph)PPAPGLQPMR ddPTM_A459_Selumetinib_30min_R2 4 SPPAPGLQPMR 11 0 P15408;P15408-3;P15408-2;C9JCN8 P15408 FOSL2 Fos-related antigen 2 1 S(1)PPAPGLQPMR;S(1)PPAPGLQPMR;S(1)PPAPGLQPMR;S(1)PPAPGLQPMR 130.1 0.002459 275743800.0 3974.7 4419.200000000001 16706.0 17209.8 19878.0 13415.100000000002 10661.800000000001 17705.300000000003 11713.199999999999 15642.899999999998 True False 3753.8020859847693 4758.138430032373 15631.1541481175 14865.795551439089 17380.74792842528 15262.908254847018 11157.5948259559 17756.8194917298 14056.16729415282 15191.248831864743 0.2471029292937983 0.3132157522199119 1.0289578112452495 0.9785762655837095 1.1441289732525417 1.0047171515505666 0.7344751540473775 1.168884776245886 0.9252805644700515 1.0 13.890952854358527 -5.24874371489954 7.013684891841906 0.9999794273075134 0.2752605123616479 0.8650465441784464 0.11344377223154098 0.04819943098487178 13.588918126851766 0.029062840172081408 0.07203489902033494 5.6397036685387195e-06 5.24874371489954 -0.7247189149458655 S(ph)PPAPPPYK ddPTM_A459_Selumetinib_30min_R2 1 SPPAPPPYK 9 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 S(1)PPAPPPYK 95.523 0.0223 10136000.0 56337.0 42793.0 51547.0 55296.0 61177.0 54874.0 61426.0 53926.0 52766.0 48530.0 True False 53206.01507487959 46075.085498817774 48230.52214013007 47764.58940907945 53491.3983306808 62432.39540342417 64282.43071330987 54082.91573207011 63320.674405223814 47128.81280391716 1.12894876635758 0.977641547868318 1.0233765560952417 1.0134901892777883 1.1350041545335683 1.3247181859466453 1.363973053612905 1.1475552324452984 1.3435660827840936 1.0 15.524321719220692 -6.521739334021294 4.160056549633931 1.252736929594988 1.0332701112665867 0.4335440089636228 0.10674510380091216 0.17696303707586014 7.257413350920659 0.03371866951936094 0.03572674369129962 3.0078811080224995e-07 6.521739334021294 -0.2194668183284012 S(ph)PPAVVEEK ddPTM_A459_Selumetinib_30min_R1 1 SPPAVVEEK 9 0 Q5T7W0-2;Q5T7W0-4;Q5T7W0 Q5T7W0-2 ZNF618 Zinc finger protein 618 1 S(1)PPAVVEEK 87.789 0.032055 19993000.0 1927.7 2214.5 2283.5 1936.1 2057.9 1702.9 2222.4 2009.9 1032.6 1563.9 True False 1972.6116593487543 1955.2253105068805 1973.4132423676494 1597.9964800981427 1871.7633083517549 1685.7703721094895 2054.762578735495 1956.5909229246952 1752.2467818799441 1764.6417986760082 1.1178538674697513 1.1080012453370793 1.1183081143426843 0.9055642234571925 1.0607043932406672 0.9553045685386716 1.164407745683663 1.1087751204764074 0.9929759020752178 1.0 10.785159647920675 S(ph)PPEEPPDFCCPK ddPTM_A459_Selumetinib_30min_R1 1 SPPEEPPDFCCPK 13 0 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9-3;Q9Y6K9;Q9Y6K9-2 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 S(1)PPEEPPDFCCPK 129.37 0.0017325 7824300.0 1432.2 1300.8 1375.8 1475.6 1553.3 1184.6 1245.2 1441.5 742.18 1025.1 True False 1465.567473423919 1148.5017312744862 1188.9739167284486 1217.9141604425486 1412.8042892573887 1172.6839995307428 1151.2735614837284 1403.2667373481 1259.4252533175065 1156.6815703195698 1.2670448903400524 0.9929281841649611 1.0279180953838116 1.0529381566147555 1.2214288923675485 1.013834774947397 0.9953245482813846 1.2131832765005526 1.0888262471144505 1.0 10.17577603575393 S(ph)PPEEPPDFCCPK ddPTM_A459_Selumetinib_30min_R2 2 SPPEEPPDFCCPK 13 0 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9-3;Q9Y6K9;Q9Y6K9-2 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 S(1)PPEEPPDFCCPK;S(1)PPEEPPDFCCPK 143.55 0.0007166000000000001 19387500.0 94457.0 90838.0 98033.0 101337.0 103137.0 71481.0 77825.0 88332.0 67878.0 95111.0 True False 89207.45808133035 97804.98250979373 91725.6635102601 87534.72578392451 90180.00800352135 81326.85891008793 81444.01670731191 88589.03149585014 81455.49666978346 92364.8983019445 0.9658155827737464 1.0588977447911585 0.99307924543375 0.9477055395846379 0.9763450148423196 0.8804953007605467 0.8817637241484119 0.9591201108266162 0.8818880133825538 1.0 16.495057063797667 -6.01013751859321 1.4159000532829538 0.9193978713528979 1.0143265254134985 0.3739521217932301 0.04417456491396162 0.3917376198753508 1.5906155973651872 0.015206609419203942 0.026927001956420567 9.76927829474237e-07 6.01013751859321 0.09492865406060069 S(ph)PPEGDTTLFLSR ddPTM_A459_Selumetinib_30min_R1 2 SPPEGDTTLFLSR 13 0 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(1)PPEGDTTLFLSR;S(1)PPEGDTTLFLSR 201.08 0.00010161 74362000.0 0.0 289.89 175.62 111.12 289.92 68.533 335.15999999999997 112.08 123.1 130.012 True False 0.0 255.94954403379532 151.77176861160788 91.71497798073737 263.69678718953344 67.8436202429853 309.87861136113594 109.10727431285125 208.89170913172688 146.70030662412248 0.0 1.7447103548978444 1.0345702207731546 0.6251860005700652 1.797520354645072 0.4624640657147033 2.112324224073445 0.7437426466490448 1.4239350546618288 1.0 7.196728076223237 -4.74461661952027 24.77073624884546 1.2065364062576232 3.88813094211233e-06 0.3313027497119727 0.5181338866239842 1028.3299012262414 1514076.9686509422 0.11825238464268543 3.2600186657041403 1.8004595986453476e-05 4.74461661952027 -1.206532518126681 S(ph)PPEGDTTLFLSR ddPTM_A459_Selumetinib_30min_R2 3 SPPEGDTTLFLSR 13 0 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(1)PPEGDTTLFLSR;S(1)PPEGDTTLFLSR;S(1)PPEGDTTLFLSR 128.35 0.0018347 48830700.0 5834.86 4805.74 8584.050000000001 5342.4 9471.9 5421.200000000001 8939.9 6084.0 5073.33 2427.0 True False 5510.581839995244 5174.3248051103765 8031.761568606969 4614.755903845958 8281.955242139624 6167.921091246179 9355.623064075788 6101.703432739583 6088.137760684045 2356.9262038967026 2.3380374959914345 2.1953698832639192 3.407727214932767 1.9579551944462192 3.5138797423725356 2.616934327875333 3.9694170520095833 2.5888394056002455 2.5830837429778395 1.0 11.202690872720266 -5.178449889905782 24.9999884914543 2.8057541263167147 2.2666991203759075 0.03432264589411904 0.796235052121253 255.13009545873183 76851.71753038303 0.18813368115060763 0.4977553338626577 6.630558484682956e-06 5.178449889905782 -0.5390550059408072 S(ph)PPEHYVQETPLMFSR ddPTM_A459_Selumetinib_30min_R1 2 SPPEHYVQETPLMFSR 16 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(1)PPEHYVQETPLMFSR;S(1)PPEHYVQETPLMFSR 128.73 0.00045257 5055400.0 1864.37 2267.8 1810.76 1802.63 2072.63 1847.37 2128.92 2105.79 1085.58 1782.39 True False 1907.8061935674834 2002.284921728383 1564.868737792706 1487.8345100559452 1885.160982452547 1828.7871350777546 1968.3338503966754 2049.937608630078 1842.1499723738432 2011.1771184488323 0.9486017795582936 0.9955786108349783 0.7780859892636646 0.7397829342865001 0.9373420993902922 0.9093118245538959 0.9786974167222026 1.019272539362988 0.9159561112124449 1.0 10.973824425805926 -6.952344261079358 1.9796012748358165 0.9793784581077101 0.8707086522030041 0.2778064163071543 0.07564279754372974 0.4848399207575971 3.849927195345242 0.03631439208191354 0.02911823971549922 1.1159782717754102e-07 6.952344261079358 -0.10866980590470599 S(ph)PPEHYVQETPLMFSR ddPTM_A459_Selumetinib_30min_R2 1 SPPEHYVQETPLMFSR 16 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.999)PPEHY(0.001)VQETPLMFSR 81.639 0.014074 4570900.0 4879.4 6367.8 6778.3 7257.3 6373.8 5800.1 5171.6 5865.4 6790.2 6730.6 True False 4608.222481785814 6856.189784295839 6342.191557655027 6268.84322045921 5573.066261505036 6599.011126934438 5412.089647330988 5882.467342930756 8148.429734039932 6536.270089801051 0.7050232653293061 1.0489452990925174 0.9703074491293044 0.9590857070366288 0.8526370827608606 1.0095989052275067 0.8280088755475096 0.8999731134289471 1.2466482599540116 1.0 12.674251883991126 -8.241346640484123 24.724979575090487 1.1233241335174922 0.9163107349044114 0.38161850127463937 0.10872833747259612 611.435054424865 752399.7872527358 0.06933344083358792 0.02613139314491837 5.736584029521688e-09 8.241346640484123 -0.20701339861308077 S(ph)PPGAAASAAAKPPPLSAK ddPTM_A459_Selumetinib_30min_R1 2 SPPGAAASAAAKPPPLSAK 19 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 S(1)PPGAAASAAAKPPPLSAK;S(0.999)PPGAAAS(0.001)AAAKPPPLSAK 114.55 0.0002664 133053000.0 7929.400000000001 9737.400000000001 8244.8 8060.5 9057.0 7573.5 9130.5 7696.9 4764.5 7977.4 True False 8114.13959207347 8597.34068120556 7125.201445444621 6652.884989324458 8237.795949143223 7497.317466187811 8441.779033992278 7492.75320894526 8085.00851468816 9001.376996456287 0.9014331468694057 0.9551139436322031 0.7915679399107171 0.739096361805933 0.9151706402682973 0.8329078394493862 0.9378319603007056 0.8324007773360731 0.8981968556445433 1.0 13.135930000993385 -9.522486361075782 0.6142437270494828 1.0082521373734992 0.8589442972798892 0.28958625940412985 0.06395203775015311 6.160424568994321 2.675590112418373 0.18988899472528167 0.027202565836882513 3.00271171889227e-10 9.522486361075782 -0.14930784009360998 S(ph)PPGAAASAAAKPPPLSAK ddPTM_A459_Selumetinib_30min_R2 1 SPPGAAASAAAKPPPLSAK 19 1 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 S(0.996)PPGAAAS(0.004)AAAKPPPLSAK 71.263 0.008058800000000001 93266000.0 170420.0 140800.0 188240.0 176810.0 196710.0 110210.0 137390.0 159010.0 130130.0 153990.0 True False 160948.73864531267 151598.90725664332 176128.84334021527 152728.1729857374 171997.53119028773 125390.4271132299 143778.9072331203 159472.69277447733 156159.63613599236 149543.9085859308 1.0762640897059905 1.0137417745071955 1.17777343795323 1.0212931735562927 1.1501473568310183 0.8384856882430498 0.9614494404531507 1.06639377211972 1.0442393649639032 1.0 17.190209620388224 -6.72197372283564 24.999999680638556 0.9849709416068333 1.0850259504548307 0.33855984554646035 0.07378522329712363 203.71707915098668 129046.47357902673 0.02488976008396745 0.02488936830401476 1.8968206856466551e-07 6.72197372283564 0.10005500884799745 S(ph)PPGPAGSSPK ddPTM_A459_Selumetinib_30min_R2 1 SPPGPAGSSPK 11 0 Q9H9D4 Q9H9D4 ZNF408 Zinc finger protein 408 1 S(1)PPGPAGSSPK 91.202 0.02675 6003900.0 20311.0 18018.0 20708.0 16535.0 17729.0 13820.0 16513.0 16674.0 16551.0 14652.0 True False 19182.195931375125 19399.92266299859 19375.66982516564 14282.904475534016 15501.724520729034 15723.579554530766 17280.88721988874 16722.51857947071 19861.66247357881 14228.958689532139 1.348109608715566 1.363411271779894 1.3617068014555274 1.0037912673147027 1.0894489792941233 1.1050407761811958 1.2144871312755883 1.1752454233894865 1.395861981677584 1.0 13.796542465277692 -5.7335961210263005 24.96675032063151 1.1473270481394313 1.35830965635196 0.4627199551958878 0.10707330862609574 202.1997139637728 181308.73898245188 0.0297678827712571 0.051544852295443026 1.8467320183085014e-06 5.7335961210263005 0.2109826082125288 S(ph)PPGSGASTPVGPWDQAVQR ddPTM_A459_Selumetinib_30min_R1 2 SPPGSGASTPVGPWDQAVQR 20 0 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-2 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 S(1)PPGSGASTPVGPWDQAVQR;S(1)PPGSGASTPVGPWDQAVQR 233.57 2.6469e-24 76894000.0 748.5699999999999 429.03999999999996 379.16999999999996 568.76 554.28 496.99 550.14 559.51 96.425 656.3 True False 766.0102245363377 378.80779734471525 327.680796631724 469.4367429474818 504.14547186608195 491.99073183081543 508.6424968797449 544.6699772553834 163.62618239664306 740.5424979033593 1.0343906348455127 0.5115274253904462 0.44248749742177024 0.6339092547376575 0.6807785823142224 0.6643652906129638 0.6868511912818307 0.7355013099146442 0.22095447980352947 1.0 9.532438720366677 -11.288658853161625 7.169080116145099 1.0078887062738873 0.6231681632557784 0.2429107893331096 0.19944791908755963 0.02430548635700546 0.0007940795296234272 0.1866457949795218 0.0450921849990457 5.144476015931863e-12 11.288658853161625 -0.3847205430181089 S(ph)PPGSGASTPVGPWDQAVQR ddPTM_A459_Selumetinib_30min_R2 4 SPPGSGASTPVGPWDQAVQR 20 0 Q8TE77;C9JUG3;Q8TE77-4;Q8TE77-2 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 S(1)PPGSGASTPVGPWDQAVQR;S(1)PPGSGASTPVGPWDQAVQR;S(1)PPGSGASTPVGPWDQAVQR;S(0.985)PPGS(0.015)GASTPVGPWDQAVQR 174.68 2.7285000000000005e-10 93960000.0 9042.4 3838.7 12773.1 9257.7 9952.6 7254.9 7781.5 2676.3999999999996 6335.76 10592.6 True False 8539.859607595206 4133.115946634068 11951.292652299759 7996.785289576729 8702.265410627102 8254.19662157491 8143.355168749731 2684.1878808981264 7603.089035925424 10286.76411511999 0.8301793948053016 0.4017897076651161 1.1618126476462276 0.7773858912369404 0.8459672364641945 0.8024094388868593 0.7916342863136356 0.2609360777460402 0.7391137728870473 1.0 13.328501607723439 -7.573599546686832 24.999835115983846 0.6052718568288394 0.8016538070539093 0.04411400658868858 0.24192223454728728 227.77617540926332 112266.21507260829 0.10907753752954291 0.06297594106344528 2.6693188498368755e-08 7.573599546686832 0.19638195022506988 S(ph)PPGSPSTPTEQR ddPTM_A459_Selumetinib_30min_R2 1 SPPGSPSTPTEQR 13 0 O75864-2;O75864 O75864-2 PPP1R37 Protein phosphatase 1 regulatory subunit 37 1 S(1)PPGSPSTPTEQR 89.74700000000001 0.027979 0.0 2699.6 2175.0 2270.9 2467.2 2490.5 2151.7 2092.3 3230.6 1134.4 2344.1 True False 2549.5670393550417 2341.815506272721 2124.792766368973 2131.1631038426076 2177.6211246475086 2448.077143812147 2189.5960958137966 3240.0005111453775 1361.3116977842922 2276.41974229677 1.1199898647789281 1.028727463024886 0.933392347153511 0.9361907491157113 0.9565991210612241 1.075406744338891 0.9618595618067459 1.4232878282264467 0.5980055753737273 1.0 11.15255088110177 -6.756102531097246 24.778724724916742 1.035051653205635 0.990167190796152 0.0 0.19379249721201064 843.5908192300886 3916736.393130729 0.06173112285677231 0.05998169859222659 1.7534664830732773e-07 6.756102531097246 -0.04488446240948307 S(ph)PPKVPIVIQDDSLPAGPPPQIR ddPTM_A459_Selumetinib_30min_R1 2 SPPKVPIVIQDDSLPAGPPPQIR 23 1 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 S(1)PPKVPIVIQDDSLPAGPPPQIR;S(1)PPKVPIVIQDDSLPAGPPPQIR 144.73 1.7839000000000005e-07 78291000.0 4802.4 5743.2 4872.1 5230.7 4343.6 4678.6 4854.3 4766.2 3214.3 4837.2 True False 4914.286576156282 5070.783474058754 4210.495580529635 4317.256437399592 3950.722146924867 4631.537531828916 4488.136242780651 4639.784893200496 5454.432336816491 5458.101738318042 0.9003655138298426 0.929037917791059 0.7714212344138409 0.790981305293512 0.723827135575218 0.8485619641923643 0.8222888575476985 0.8500729952736797 0.999327714711547 1.0 12.414183571175743 -8.22581009989668 3.671312691959073 1.0052966336449105 0.8246055281179753 0.5974442954924801 0.05606506092794228 0.16846111927061158 4.59979869072606 0.051954436562541714 0.015996155496779043 5.945520763083518e-09 8.22581009989668 -0.18069110552693524 S(ph)PPKVPIVIQDDSLPAGPPPQIR ddPTM_A459_Selumetinib_30min_R2 2 SPPKVPIVIQDDSLPAGPPPQIR 23 1 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 S(1)PPKVPIVIQDDSLPAGPPPQIR;S(1)PPKVPIVIQDDSLPAGPPPQIR 145.66 8.3065e-08 50571000.0 27964.0 23094.3 25873.0 27717.7 21708.8 21981.7 29628.0 22479.4 18003.7 20299.6 True False 26409.87282876145 24865.558550121452 24208.359348392445 23942.50144430053 18981.546464865623 25009.47964499485 31005.760706768233 22544.811332335004 21604.94306540819 19713.49780330511 1.3396847729545818 1.2613468598125983 1.228009336036436 1.2145232511851043 0.9628705496232755 1.2686474969856356 1.5728188379420873 1.1436230930340128 1.095946710268026 1.0 14.266896158760465 -4.907755779342764 1.6277166150604314 1.1990226916847146 1.3675617116328638 0.08365084903131981 0.15944875208967418 2.5236048847254953 7.921824615406396 0.04774479533451441 0.6288563611540281 1.2366426501517673e-05 4.907755779342764 0.16853901994814913 S(ph)PPLGLISRPR ddPTM_A459_Selumetinib_30min_R2 1 SPPLGLISRPR 11 1 Q16584;Q16584-2;E9PID4 Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 1 S(1)PPLGLISRPR 64.10300000000001 0.046363 2917700.0 5120.4 6033.4 4568.0 5944.1 6447.1 6917.7 5351.7 4613.4 6651.4 8099.1 True False 4835.8286665852565 6496.14237956131 4274.09985326235 5134.503325855567 5637.157660194721 7870.550382371742 5600.56465419237 4626.824230210513 7981.8658556439 7865.257939011042 0.6148340847920496 0.8259287145995517 0.5434150903129522 0.6528080026961158 0.7167161845048813 1.0006728887217353 0.71206369805293 0.5882609656400255 1.0148256951694479 1.0 12.94127836387331 -6.536944510900209 24.957917111519873 0.8313991086495066 0.6656140801941797 0.30256930788161995 0.1440341144735629 351.6804630506783 624008.1784945731 0.047317019498452136 0.047337288025400735 2.9043937204218176e-07 6.536944510900209 -0.16578502845532694 S(ph)PPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R1 2 SPPLIGSESAYESFLSADDK 20 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.999)PPLIGS(0.001)ESAYESFLSADDK;S(1)PPLIGSESAYESFLSADDK 158.89 7.909899999999999e-07 35550000.0 7661.3 9103.1 3906.1 3376.4 4763.200000000001 5591.1 7191.200000000001 6320.9 3707.9 7521.099999999999 True False 7839.793383705251 8037.304820083622 3375.67307467146 2786.7751228776247 4332.369401011264 5534.858610312627 6648.761994331667 6153.249198823176 6292.035485698867 8486.506446717893 0.923795136777071 0.9470687226299113 0.3977694585947062 0.3283771879953492 0.510500926171662 0.6521951812636874 0.7834510037876702 0.7250626906909273 0.741416450361889 1.0 13.050955061142092 -8.622877895521922 0.7716479061717981 0.9937998529911951 0.6240650875956608 0.23508764151348926 0.19122753987008706 1.3280152549435842 1.7292938762463028 0.21280302651701852 0.07841858262868388 2.382989366823123e-09 8.622877895521922 -0.3697347653955343 S(ph)PPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R2 4 SPPLIGSESAYESFLSADDK 20 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.982)PPLIGS(0.014)ES(0.004)AYESFLSADDK;S(0.996)PPLIGS(0.004)ESAYESFLSADDK;S(1)PPLIGSESAYESFLSADDK;S(0.992)PPLIGS(0.008)ESAYESFLSADDK 165.41 2.4996e-09 19269200.0 95020.0 61895.8 80980.0 101905.0 92250.5 86978.0 130299.0 129555.0 109980.0 72863.3 True False 89739.16879519784 66643.00883363445 75769.83496435749 88025.36320406989 80661.1674600663 98958.42999232841 136358.16168257032 129931.983601015 131979.07309795183 70759.54720741109 1.2682270073344801 0.9418235625263373 1.0708072331534315 1.244006875087104 1.1399333467133625 1.398517004387556 1.9270637965344228 1.8362466794785597 1.8651769027166534 1.0 16.11063719575599 -6.987895325582681 3.432765276664386 1.725524227787763 1.1267080060548704 0.4652824813160046 0.2598362260604821 0.1813666605664022 4.525585388517695 0.09586347716711735 0.0789174031872612 1.0282641022785918e-07 6.987895325582681 -0.5988162217328925 S(ph)PPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 1 SPPLIGSESAYESFLSADDKASGR 24 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.994)PPLIGS(0.006)ESAYESFLSADDKASGR 182.23 9.3966e-21 43103000.0 1535.2 1227.9 1759.1 1627.6 1884.7 1101.7 1496.3 1535.9 880.52 1121.9 True False 1570.9671730208058 1084.1368971647767 1520.2238820446385 1343.3702138359251 1714.2292177708111 1090.617898263565 1383.4328863219596 1495.1629426936859 1494.178129363674 1265.9067932314167 1.2409817068843407 0.8564113116079857 1.2008971672898914 1.0611920411666103 1.3541512115556187 0.8615309627019216 1.0928394520978435 1.1811003390518653 1.1803223881511533 1.0 10.305955469923553 S(ph)PPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R2 3 SPPLIGSESAYESFLSADDKASGR 24 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.993)PPLIGS(0.006)ES(0.001)AYESFLSADDKASGR;S(1)PPLIGSESAYESFLSADDKASGR;S(0.999)PPLIGS(0.001)ESAYESFLSADDKASGR 138.04 3.4949e-08 54323200.0 106038.0 112178.0 121562.0 134764.0 123701.0 85037.0 79929.8 80382.0 61340.7 110651.0 True False 100144.83246374648 120781.69189087857 113740.8332666985 116408.91071913314 108160.57447902899 96750.074860972 83646.69407789403 80615.8983120436 73610.55400235977 107456.21812417539 0.9319593990179337 1.1240084008103133 1.058485355731212 1.0833147932361822 1.0065548217418154 0.9003673919471885 0.7784258141416508 0.7502208780406233 0.6850283332817103 1.0 16.71338944345053 -6.908808193784529 2.0724022619960967 0.7819172019895917 1.054722466788976 0.6111826292918094 0.08918505881225527 0.19022195422460123 1.6643942599943402 0.03590990915832184 0.029851788815436615 1.2336495544211132e-07 6.908808193784529 0.2728052647993844 S(ph)PPLPAVIR ddPTM_A459_Selumetinib_30min_R1 5 SPPLPAVIR 9 0 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR 112.3 0.0097763 342591000.0 3307.71 4405.24 3646.12 4419.84 3544.9100000000003 3446.0599999999995 3824.2799999999997 4191.62 2538.88 4368.03 True False 3384.7732073167363 3889.4724528594847 3150.996930703541 3647.9979146722676 3224.2735164046944 3411.3957651721353 3535.8114806545063 4080.444621299374 4308.2939275415 4928.70919871524 0.6867463814255953 0.7891462644769849 0.6393148395780597 0.7401528001739657 0.6541821370279183 0.6921479088401846 0.7173909715704432 0.8278931575762307 0.8741221593403273 1.0 12.266994146996481 -8.249428848175716 1.1872098427848485 0.992991414771512 0.699227667438374 0.8433510500085866 0.04225501751197532 0.15882779644961054 0.4445223493214581 0.03845114264270313 0.012539010762577001 5.630813612195563e-09 8.249428848175716 -0.29376374733313804 S(ph)PPLPAVIR ddPTM_A459_Selumetinib_30min_R2 6 SPPLPAVIR 9 0 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR;S(1)PPLPAVIR 112.3 0.0097763 343343700.0 22104.5 17483.1 23479.500000000004 21468.7 24986.1 18685.800000000003 16560.7 23163.0 17854.3 23520.600000000002 True False 20876.020381324455 18823.997552973153 21968.854532546702 18544.6260244268 21847.122739431885 21259.59933719617 17330.80536440451 23230.400495158912 21425.658890823408 22841.49916414208 0.9139514106016672 0.8241139260475584 0.9617956498684944 0.8118830507210858 0.9564662364074936 0.930744483294281 0.7587420265133658 1.0170260860822724 0.9380145644931511 1.0 14.479369722268357 -7.812995998121029 24.99999991998615 0.9831404056767358 0.8830025433979986 0.35447046228257284 0.06502145196963326 119.63699907741486 58010.73238112986 0.03372019302560258 0.016198680387715953 1.53816881395093e-08 7.812995998121029 -0.10013786227873722 S(ph)PPLSPVGTTPVK ddPTM_A459_Selumetinib_30min_R2 2 SPPLSPVGTTPVK 13 0 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 S(1)PPLSPVGTTPVK;S(1)PPLSPVGTTPVK 184.11 0.00010376 20866400.0 39273.0 24826.0 37511.0 38447.0 39538.0 33742.0 46424.0 47302.0 37764.0 30448.0 True False 37090.36388227536 26730.074371828312 35097.583098888776 33210.452275225674 34570.88296579531 38389.65422062063 48582.80798741082 47439.640988732346 45317.855214321215 29568.887126595313 1.254371316833056 0.9039932499788377 1.186976802631194 1.1231552994551157 1.1691641561545623 1.2983124476839578 1.643038095394321 1.6043769515445658 1.532619574767855 1.0 14.851792325843155 -6.93294781067943 2.9230960619075876 1.4947408838183702 1.1155926105042748 0.3733884908190195 0.18839787927989743 0.22938839173170672 3.976410427648782 0.06990121132702175 0.058942414768721293 1.1669498414080824e-07 6.93294781067943 -0.3791482733140954 S(ph)PPPESVDTPTSTK ddPTM_A459_Selumetinib_30min_R1 2 SPPPESVDTPTSTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(1)PPPESVDTPTSTK;S(1)PPPESVDTPTSTK 166.38 0.0002339 12057600.0 1577.1399999999999 3766.1000000000004 1116.75 1379.1100000000001 1573.75 1592.22 2180.91 1734.71 829.8199999999999 1914.01 True False 1613.8842934197728 3325.163261187609 965.1014838686548 1138.2743276009235 1431.4045903681288 1576.203712420091 2016.4022028392847 1688.6998556677922 1408.1439323451632 2159.691827536202 0.7472752699448366 1.5396471009389283 0.44686999856347664 0.5270540514567202 0.6627818710603214 0.7298280672841366 0.9336527448638895 0.781917046745636 0.6520115112680627 1.0 11.07660974954885 -5.272552194289961 24.99998500722472 0.7084849941754975 1.1434612188651683 0.3409288332414372 0.2370851467553629 676.041706814625 1520860.937070174 0.06018730573533261 0.12715287207332893 5.3388510644850875e-06 5.272552194289961 0.4349762246896708 S(ph)PPPESVDTPTSTK ddPTM_A459_Selumetinib_30min_R2 2 SPPPESVDTPTSTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(1)PPPESVDTPTSTK;S(1)PPPESVDTPTSTK 119.96 0.0021358 21241300.0 40551.0 33273.0 37471.0 29197.0 35118.0 26862.0 35721.0 42072.0 33257.0 40081.0 True False 38297.33775851471 35824.932110442445 35060.15665534006 25220.318232365702 30706.162881096647 30561.996671042358 37382.09727981869 42194.42255460547 39909.329278219484 38923.75738705552 0.9839064964280881 0.9203873036768125 0.9007392659116631 0.6479415124695276 0.7888797213423256 0.7851759111314893 0.960392824055842 1.0840274780008172 1.0253205743053913 1.0 15.248363362587918 -7.46746772935437 4.209445964297917 1.039529859632681 0.8344132632219639 0.5120281600892438 0.08802959582858544 0.19455074252728285 7.066994556926564 0.04454321893328645 0.027949305640329224 3.4082564921866444e-08 7.46746772935437 -0.2051165964107171 S(ph)PPPFFYR ddPTM_A459_Selumetinib_30min_R2 1 SPPPFFYR 8 0 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 S(1)PPPFFYR 95.358 0.021952 4777100.0 740.64 1344.6 1100.9 1312.6 2600.9 640.74 965.45 1372.4 1267.2 1139.2 True False 699.4781938168318 1447.7264964295634 1030.0692925692904 1133.8216156387025 2274.151689658984 728.9961189413931 1010.3453380028826 1376.3934567869487 1520.6754085263167 1106.3083360029352 0.6322633311650071 1.3086103117148729 0.9310869845660799 1.0248694498092386 2.0556219415967147 0.6589447943375697 0.9132583612749728 1.244131868118995 1.3745493539535998 1.0 10.111537815648168 -4.751916288553801 24.619820692117276 1.1675353927761536 0.6322620372911234 0.16732401743230307 0.3584651312712011 602.034542184269 1556290.962123829 0.08921853280070555 1.1065908460705691 1.7704501845333114e-05 4.751916288553801 -0.5352733554850302 S(ph)PPPGMGLNQNR ddPTM_A459_Selumetinib_30min_R2 1 SPPPGMGLNQNR 12 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 S(1)PPPGMGLNQNR 92.112 0.022115 42508000.0 2036.9 2394.7 1730.4 0.0 1986.4 2295.4 1856.4 0.0 0.0 2481.4 True False 1923.6972523567513 2578.36578982588 1619.067947917068 0.0 1736.8506733586873 2611.570514433424 1942.726278386815 0.0 0.0 2409.755534548528 0.7982956050009278 1.0699698591247104 0.6718805807081187 0.0 0.7207580389203627 1.0837491508958008 0.8061922674454146 0.0 0.0 1.0 11.234671079671786 -7.74821960417354 24.99384286710371 0.24999997873215668 0.7307267529387917 0.17790693281520042 0.38405669233001777 328.67882974529743 621416.1124987421 0.18856780916084312 0.10804639743569405 1.785584452729371e-08 7.74821960417354 0.48072677420663507 S(ph)PPPTVDESADNAFHLGPLR ddPTM_A459_Selumetinib_30min_R2 2 SPPPTVDESADNAFHLGPLR 20 0 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 S(0.872)PPPT(0.128)VDESADNAFHLGPLR;S(0.999)PPPT(0.001)VDESADNAFHLGPLR 160.2 6.2865e-07 6270000.0 9282.5 7738.4 11801.1 15076.9 17526.5 12582.7 10547.900000000001 12988.3 18607.0 11066.8 True False 8766.615810791669 8331.910397122223 11041.830074066173 13023.400210896812 15324.66438110201 14315.85271062188 11038.398250267333 13026.093802671188 22328.919923018624 10747.272729000426 0.8157060895212834 0.7752581149857124 1.0274076365691283 1.2117865191747192 1.4259119283118178 1.3320451682585484 1.027088316134505 1.2120371494362094 2.0776359255093895 1.0 13.39168298173288 -5.627584663246049 1.8330437046234387 1.3399551626248052 0.7849987110385483 0.37742484255969977 0.2807310449228601 0.38615088892252686 2.592230475713263 0.08541172463322579 0.2049147250738338 2.357302608392177e-06 5.627584663246049 -0.5549564515862568 S(ph)PPREGSQGELTPANSQSR ddPTM_A459_Selumetinib_30min_R1 2 SPPREGSQGELTPANSQSR 19 1 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 S(0.906)PPREGS(0.094)QGELTPANSQSR;S(0.976)PPREGS(0.024)QGELTPANSQSR 81.477 0.0031375 43955500.0 626.79 630.17 549.32 629.55 511.01 347.63 695.87 563.26 322.35699999999997 657.1 True False 641.3929874789674 556.389403441915 474.72536119877276 519.6109106171091 464.7892357261429 344.13315782278585 643.3799656518487 548.3205150736674 547.0162849762478 741.445185696019 0.8650578624728281 0.7504120522673755 0.640270340083377 0.700808260194357 0.6268693150793473 0.46413836715351614 0.8677377344461232 0.7395294023777912 0.7377703645924217 1.0 9.53419622938974 -9.100811507232429 0.8060546809096082 1.0020278302659908 0.6911586062123225 0.3883728139626671 0.11061319112392959 2.1967070674303772 2.119855281175465 0.12603541576875338 0.03927190442736788 7.928453670666381e-10 9.100811507232429 -0.31086922405366835 S(ph)PPSLALR ddPTM_A459_Selumetinib_30min_R1 2 SPPSLALR 8 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 S(0.999)PPS(0.001)LALR;S(1)PPSLALR 94.309 0.023785 0.0 2198.5299999999997 2612.9 2235.92 2217.68 2147.1 1947.56 2228.2 2002.19 1167.83 1882.4 True False 2249.75147140531 2306.980453295746 1932.2943450294176 1830.4038190093727 1952.8951841012927 1927.9693146429972 2060.1250800658877 1949.0854171703047 1981.7222150715238 2124.024376128727 1.0591928683538627 1.0861365242429453 0.9097326597311661 0.8617621528174216 0.9194316251966296 0.90769641643988 0.9699159309182209 0.917637970201986 0.9330035179179229 1.0 11.052584607827804 -5.261569563624477 24.999856649809875 0.922642315813752 1.0726647079806517 0.7237082194085092 0.03580660341479521 5.278998360131106 1013986.5647029304 0.009239135094497312 0.021438590003161232 5.4755838813474995e-06 5.261569563624477 0.15002239216689972 S(ph)PPSLHLLEAFK ddPTM_A459_Selumetinib_30min_R1 1 SPPSLHLLEAFK 12 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 S(0.999)PPS(0.001)LHLLEAFK 119.32 0.0028488000000000003 5317300.0 3429.9 3644.7 2512.8 2998.1 3912.8 2886.6 4488.4 3394.0 934.75 2382.7 True False 3509.8099965763836 3217.976829624938 2171.57556182239 2474.5381163071334 3558.8879308609494 2857.5634248230986 4149.836374368428 3303.9800947342706 1586.202478561183 2688.5427544634085 1.3054692884275472 1.1969223194545018 0.8077147213735876 0.9204012516442249 1.3237237626043437 1.0628670197188008 1.5435262717987428 1.22891112267013 0.5899859602112835 1.0 11.392608698868694 -8.247156354321147 24.714431267917846 0.7949929648855097 1.1674587661046083 0.32543439438268795 0.21794158791538323 741.4458435263101 1282956.627104284 0.15628312622930976 0.05844175805834433 5.6603546875435455e-09 8.247156354321147 0.37246580121909856 S(ph)PPSLHLLEAFK ddPTM_A459_Selumetinib_30min_R2 2 SPPSLHLLEAFK 12 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 S(0.999)PPS(0.001)LHLLEAFK;S(0.965)PPS(0.035)LHLLEAFK 117.95 0.0030703 22927000.0 134863.0 114299.0 179012.0 266950.0 282240.0 208077.0 165775.0 210347.0 226950.0 214957.0 True False 127367.85435936402 123065.36577078917 167494.56281352902 230590.94948556472 246782.48794238587 236737.7180150578 173483.86597693063 210959.07494517945 272346.3415128212 208750.63288464065 0.6101435602820413 0.5895328989914838 0.8023667305770015 1.1046239539450566 1.1821879748683795 1.1340694624187477 0.8310579162306105 1.0105793310900246 1.3046491775827318 1.0 17.67142104595475 -5.56175611585444 2.942001134826555 1.0777852531337397 0.6043839936165426 0.73244785073061 0.11846707552616074 0.1374710093014959 2.407216044341103 0.0354177421759154 0.07352717865605884 2.743114173644932e-06 5.56175611585444 -0.47340125951719714 S(ph)PPSPVER ddPTM_A459_Selumetinib_30min_R2 2 SPPSPVER 8 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.695)PPS(0.305)PVER;S(1)PPSPVER 89.029 0.030241000000000007 139324300.0 20105.8 17134.8 24613.0 31615.0 27639.0 20830.0 21122.7 21830.0 25171.5 18208.1 True False 18988.400125894423 18448.98406293417 23029.426376608164 27308.982461083044 24166.741724204967 23699.143424086553 22104.947403836006 21893.521685848955 30206.503350473635 17682.384842674717 1.073859679836159 1.0433538364355321 1.3023936862311063 1.5444173794462084 1.3667128014248895 1.3402685008241069 1.2501112039190474 1.2381543485588589 1.7082822039690695 1.0 14.110025245266966 -5.320661801504742 4.568189196953851 1.359675766638182 1.0568276192625923 0.2934221218157669 0.17713722023172748 0.22847278238899155 9.848827708378346 0.04492550806015725 0.10171122415524403 4.7790128524715415e-06 5.320661801504742 -0.30284814737558974 S(ph)PPSSSEIFTPAHEENVR ddPTM_A459_Selumetinib_30min_R1 6 SPPSSSEIFTPAHEENVR 18 0 I3L2L5;I3L3A7;I3L317;I3L4Q0;C9JLW8 I3L2L5 FAM195B Protein FAM195B 1 S(1)PPSSSEIFTPAHEENVR;S(1)PPSSSEIFTPAHEENVR;S(1)PPSSSEIFTPAHEENVR;S(0.986)PPS(0.013)S(0.001)S(0.001)EIFTPAHEENVR;S(0.995)PPS(0.003)S(0.001)SEIFTPAHEENVR;S(0.999)PPS(0.001)SSEIFTPAHEENVR 251.38 3.2122e-33 267736600.0 7108.34 8060.6 6769.7 6710.07 6560.51 6171.6900000000005 7193.96 6772.99 3751.6990000000005 5680.99 True False 7273.9504915781135 7116.861204728728 5850.411923300318 5538.282238113808 5967.113028852117 6109.60840204617 6651.3138053095745 6593.3483034278925 6366.359189746469 6410.200404028657 1.134746190931349 1.1102400480733725 0.912672234026174 0.8639795777107264 0.9308777655534654 0.9531072379900054 1.0376140192324381 1.028571321933107 0.9931607108173038 1.0 12.646153745621364 -5.202648907861936 7.0153375737468116 0.9634477585268951 1.124784587997586 0.6054859591013042 0.05086052820746656 0.19747558553796876 19.93234991460033 0.015126688656989974 0.04052170491276744 6.271206363686202e-06 5.202648907861936 0.16133682947069083 S(ph)PPSSSEIFTPAHEENVR ddPTM_A459_Selumetinib_30min_R2 6 SPPSSSEIFTPAHEENVR 18 0 I3L2L5;I3L3A7;I3L317;I3L4Q0;C9JLW8 I3L2L5 FAM195B Protein FAM195B 1 S(0.892)PPS(0.032)S(0.032)S(0.044)EIFTPAHEENVR;S(0.986)PPS(0.007)S(0.007)SEIFTPAHEENVR;S(0.379)PPS(0.154)S(0.202)S(0.266)EIFTPAHEENVR;S(0.999)PPS(0.001)SSEIFTPAHEENVR;S(0.399)PPS(0.399)S(0.089)S(0.113)EIFTPAHEENVR;S(0.847)PPS(0.021)S(0.111)S(0.021)EIFTPAHEENVR 168.17 7.84e-08 298074700.0 30782.699999999997 33971.85 38515.03 43072.4 34472.47 30614.4 34874.479999999996 30979.409999999996 35621.21 31349.979999999996 True False 29071.92076691156 36577.38165828552 36037.01490179399 37205.864815965615 30141.730130808068 34831.255710146645 36496.212422471115 31069.554954182597 42746.447339766215 30444.824620369836 0.9549051810750224 1.201431839873781 1.1836827884921552 1.22207518945838 0.9900444659037722 1.1440780541347564 1.1987657303846793 1.0205200831866434 1.4040628537950481 1.0 14.893909381765992 -6.992201883036761 24.96389677923658 1.1595292986355126 1.1198865561810498 0.02416739786608435 0.13090043855494224 1023.0888437308257 3275169.9495098908 0.04449314417923229 0.03918248942231571 1.0181180029587658e-07 6.992201883036761 -0.039642742454462754 S(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R1 3 SPPSTGSTYGSSQK 14 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.989)PPS(0.001)T(0.01)GS(0.001)TYGSSQK;S(0.952)PPS(0.034)T(0.014)GSTYGSSQK;S(0.507)PPS(0.185)T(0.185)GS(0.014)T(0.109)YGSSQK 124.16 0.0015220999999999998 157949000.0 2429.43 3688.75 1477.96 1773.95 1829.13 2086.85 2927.51 2814.5 1280.9 3176.98 True False 2486.030992152121 3256.869435146651 1277.2611498531598 1464.1629336656672 1663.6855144591304 2065.858183708197 2706.6855637481767 2739.8503172155597 2173.5937467654676 3584.7763294057804 0.6934968220358145 0.9085279347642078 0.35630149066089184 0.4084391323540037 0.4640974391657251 0.5762864942959043 0.7550500547399124 0.7643016092079928 0.6063401303271178 1.0 11.807667390054018 -7.254517896282752 5.134777511420361 0.7632101668604419 0.5608074228643751 0.2690911629617443 0.1713560451061226 0.29578341521170326 25.457407669353703 0.07492179911136176 0.0540086618479239 5.5652170079872635e-08 7.254517896282752 -0.20240274399606673 S(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 5 SPPSTGSTYGSSQK 14 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.953)PPS(0.032)T(0.013)GS(0.002)TYGSSQK;S(0.989)PPS(0.005)T(0.006)GSTYGSSQK;S(0.967)PPS(0.013)T(0.019)GSTYGSSQK;S(0.984)PPS(0.004)T(0.012)GSTYGSSQK;S(1)PPSTGSTYGSSQK 132.08 0.00083711 363135000.0 57335.2 37040.0 49265.3 56331.5 56273.600000000006 56893.2 73480.6 80819.1 69489.2 45424.90000000001 True False 54148.739114990785 39880.848897628355 46095.624234002964 48659.05252274234 49204.007275633034 64729.721874951516 76897.59349904659 81054.27020067771 83388.98169047254 44113.36510893589 1.2274905571423311 0.9040536535615559 1.0449355681701447 1.103045582729431 1.1153990894624801 1.467349446479644 1.7431813081852083 1.8374084588767596 1.8903337227742059 1.0 15.428928197580992 -6.871551227824427 2.541603587518327 1.68562419557258 1.058940295649428 0.5202740028133237 0.24395388867178555 0.19565345802999684 2.570396824293926 0.09127879251609435 0.07906975141283915 1.3441532058132152e-07 6.871551227824427 -0.6266838999231519 S(ph)PPSTGSTYGSSQKEESAASGGAAYTK ddPTM_A459_Selumetinib_30min_R1 2 SPPSTGSTYGSSQKEESAASGGAAYTK 27 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.95)PPS(0.026)T(0.023)GS(0.001)TYGSSQKEESAASGGAAYTK;S(0.965)PPS(0.027)T(0.006)GS(0.001)TYGSSQKEESAASGGAAYTK 82.486 4.6431e-05 67932000.0 1190.42 1767.78 1169.3400000000001 966.04 1220.52 1152.58 1419.6799999999998 1637.1000000000001 494.30999999999995 1389.96 True False 1218.1544698459027 1560.8074957813744 1010.5500507248469 797.339248816698 1110.124181500307 1140.9860916589082 1312.592394609075 1593.678789949757 838.8079670260273 1568.3749053569309 0.7766985213071074 0.9951749995809617 0.6443293929743577 0.5083856201048049 0.7078181228917744 0.7274957586746407 0.8369123926465497 1.0161338239386504 0.5348261848369292 1.0 10.615054748100315 -7.273367344520742 5.776087930353846 0.8491412121148668 0.7240462499070289 0.11087362425326452 0.16700723882403531 0.416833029206 54.855367621579525 0.07091147909243566 0.049817080717980945 5.328839691567465e-08 7.273367344520742 -0.1250949622078379 S(ph)PPSTGSTYGSSQKEESAASGGAAYTK ddPTM_A459_Selumetinib_30min_R2 2 SPPSTGSTYGSSQKEESAASGGAAYTK 27 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.971)PPS(0.024)T(0.004)GSTYGSSQKEESAASGGAAYTK;S(0.951)PPS(0.039)T(0.009)GS(0.001)TYGSSQKEESAASGGAAYTK 93.093 6.2678e-06 82654000.0 43922.3 39951.0 39857.3 47471.0 44351.9 38329.6 43348.8 46534.0 38189.2 39549.0 True False 41481.27440089789 43015.11323728807 37292.92471134704 41005.36790795739 38780.01781098328 43609.15447853421 45364.60509401764 46669.40623588158 45828.10709540184 38407.11760935753 1.0800413304327574 1.119977647757869 0.9709899370907484 1.0676502289244123 1.0097091431181728 1.1354446048799367 1.1811509927775727 1.2151238921535477 1.193219120516252 1.0 15.229086075604764 -6.906888850259576 5.346858046932115 1.164416916231532 1.0506269110052957 0.3251116757792303 0.06691894215109397 0.21216335988770646 9.684241640539152 0.023245644270854984 0.020434192646852787 1.2391136744652576e-07 6.906888850259576 -0.11379000522623639 S(ph)PPSYSVLYPSSDPK ddPTM_A459_Selumetinib_30min_R1 2 SPPSYSVLYPSSDPK 15 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.997)PPS(0.003)YSVLYPSSDPK;S(1)PPSYSVLYPSSDPK 169.98 5.5634e-05 44851000.0 4685.6 4555.1 5481.5 5620.1 4852.6 4668.9 4826.8 4428.9 2961.6 3404.5 True False 4794.765363409515 4021.786774391463 4737.142407724224 4638.655037342891 4413.683186796114 4621.935105022017 4462.710589921026 4311.4311849053065 5025.618893294252 3841.500737638256 1.2481490154176889 1.0469311472432636 1.2331488996762774 1.2075111666371106 1.1489476348531522 1.2031587186063042 1.161710199921682 1.1223299120218215 1.3082436361535072 1.0 11.90745431534243 -11.48734567167932 2.8106892594236013 0.8559537060117274 1.1812979020383634 0.39621094824454495 0.06884745032291233 14468236.026901348 5464536.068144827 13467640.854408016 0.016666204153255072 3.2557745822568072e-12 11.48734567167932 0.325344196026636 S(ph)PPTQVAISSDSAR ddPTM_A459_Selumetinib_30min_R1 1 SPPTQVAISSDSAR 14 0 Q6ZUT6;H0YM82;Q6ZUT6-3;Q6ZUT6-4 Q6ZUT6 C15orf52 Uncharacterized protein C15orf52 1 S(1)PPTQVAISSDSAR 98.408 0.010415 9170300.0 256.49 237.85 244.7 368.14 464.52 294.63 239.51 306.97 121.76 172.62 True False 262.4657179573389 210.00241142653482 211.47108404088624 303.85125984367033 422.5042480176669 291.6662897026362 221.44356786939275 298.8281584209133 206.6178270014547 194.77745846118836 1.3475158780226009 1.0781658878066744 1.0857061474750902 1.559991912022079 2.1691639851736526 1.4974334915698373 1.1369055208897179 1.5342029862272706 1.0607892136688173 1.0 7.605682914176588 -8.329411861224088 5.9425888730687815 1.0152017461858585 1.4249154347824498 0.2151342542672774 0.3025158375948936 0.427613561011142 27.89757633790728 0.3208295977391429 0.08420653757972389 4.683689958261427e-09 8.329411861224088 0.4097136885965913 S(ph)PPTQVAISSDSAR ddPTM_A459_Selumetinib_30min_R2 2 SPPTQVAISSDSAR 14 0 Q6ZUT6;H0YM82;Q6ZUT6-3;Q6ZUT6-4 Q6ZUT6 C15orf52 Uncharacterized protein C15orf52 1 S(1)PPTQVAISSDSAR;S(0.999)PPT(0.001)QVAISSDSAR 137.27 0.00058833 32543000.0 0.0 1454.1 3598.8999999999996 3593.0 4815.9 4512.299999999999 3057.8 6027.1 4486.1 5190.9 True False 0.0 1565.6247943315702 3367.3506921860458 3103.627201729286 4210.883587307741 5133.828366418901 3199.9937589157507 6044.637863159879 5383.445352106938 5041.0252294220845 0.0 0.31057666309499055 0.6679892559419083 0.6156738084973031 0.8353228551070925 1.0184095759837044 0.6347902685031008 1.1990889924295918 1.067926682986292 1.0 12.299501459455911 -5.4924026890912705 0.7361002005000178 1.0001932147482675 5.45770734966815e-25 0.8147696640185896 0.15130678369002237 0.5854507905831239 0.4534765615379281 0.07297841927546796 0.41685061634326576 3.2180835171044053e-06 5.4924026890912705 -1.0001932147482675 down S(ph)PPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNK ddPTM_A459_Selumetinib_30min_R1 2 SPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNK 37 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 S(0.917)PPVQPHT(0.049)PVT(0.014)IS(0.016)LGT(0.003)APS(0.002)LQNNQPVEFNHAINYVNK;S(0.81)PPVQPHT(0.124)PVT(0.036)IS(0.013)LGT(0.012)APS(0.004)LQNNQPVEFNHAINYVNK 51.976000000000006 0.0020535 188716000.0 3649.3 3106.0 16111.7 16374.3 7962.1 6356.200000000001 4252.0 3498.3 3002.6000000000004 2351.55 True False 3734.3215896983015 2742.348076059775 13923.819635233136 13514.835888678794 7241.929460822932 6292.262398967845 3931.2682166951627 3405.5137199201263 5095.192898772731 2653.394348536713 1.4073752707575093 1.0335245032733704 5.247550045816524 5.093413987307209 2.729307637523496 2.3714011460218436 1.4815996796191142 1.2834555563888157 1.9202546736344013 1.0 11.373623390081427 -6.977279393905885 2.30546730766445 1.444038580214997 3.2257952442023203 0.2777204525494388 1.2772522873213186 0.4605306793055542 4.933746796077521 0.6036626837261468 0.48420796960017476 1.0537087976654278e-07 6.977279393905885 1.7817566639873232 S(ph)PPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNK ddPTM_A459_Selumetinib_30min_R2 1 SPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNK 37 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 S(0.965)PPVQPHT(0.03)PVT(0.004)ISLGTAPSLQNNQPVEFNHAINYVNK 57.95 0.00016628 33403000.0 48834.0 40770.0 51928.0 53020.0 59416.0 44756.0 39627.0 38747.0 37780.0 45275.0 True False 46120.00177799086 43896.92790378801 48587.009014931515 45798.584535398455 51951.630894220594 50920.73274548327 41469.73401941086 38859.74735508886 45337.05566139858 43967.79311142286 1.048949663248139 0.9983882473369708 1.1050590802181648 1.041639374970129 1.1815837734353678 1.1581371076879006 0.943184342100559 0.8838230123720509 1.031142398857858 1.0 15.424159500294026 -7.278080568046673 24.847964525863965 0.9548560078757268 1.0876337372325975 0.4870929674035286 0.06222313565364078 677.7791039047036 1012028.7285503641 0.027550144845681093 0.01863701740013374 5.2713206156130344e-08 7.278080568046673 0.1327777293568707 S(ph)PQEGGSHVGR ddPTM_A459_Selumetinib_30min_R2 1 SPQEGGSHVGR 11 0 Q8TC76 Q8TC76 FAM110B Protein FAM110B 1 S(1)PQEGGSHVGR 90.759 0.027958 0.0 1102.8 703.34 1261.3 2058.8 1251.0 1091.5 903.53 2145.1 1285.6 1155.6 True False 1041.5107908581788 757.2839164054517 1180.1493311996055 1778.3878883719037 1093.8381959181024 1241.8442173495184 945.5459353107293 2151.3418858595787 1542.7559226652716 1122.234825390618 0.9280684998308251 0.6747998718912174 1.0516064058062262 1.584684281877367 0.9746963569209933 1.1065814295303729 0.8425562225638575 1.917015794899038 1.3747175615658533 1.0 10.132158873246386 -5.52118527066433 24.99998699406568 1.2645344598461263 0.816876365299136 0.26310815086764916 0.3049453945682641 82.10273051798686 1212043.339208334 0.0851956837461214 0.15041324708869722 3.011720945515234e-06 5.52118527066433 -0.44765809454699035 S(ph)PQEGPTWSR ddPTM_A459_Selumetinib_30min_R2 1 SPQEGPTWSR 10 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(1)PQEGPTWSR 82.505 0.042458 5241500.0 24487.0 27104.0 51290.0 40729.0 83952.0 53478.0 23926.0 37111.0 61965.0 32052.0 True False 23126.110569227625 29182.789646903842 47990.057240329654 35181.6399385561 73405.19921959753 60844.109075050415 25038.606408469586 37218.986865943225 74359.7314467592 31126.575478902832 0.7429699609872659 0.9375522105438017 1.5417711875454034 1.1302766011764365 2.3582806039601296 1.9547318694370899 0.8044125003548949 1.1957302174525992 2.3889467537846945 1.0 14.9258592409254 -5.154923722038985 1.65422298626342 1.5784755362995857 0.6612347989763786 0.23138954995185113 0.5185609860225154 0.8127866046963177 3.4707009604641144 0.15418694338919797 0.9447205152246572 6.999649245932321e-06 5.154923722038985 -0.9172407373232071 S(ph)PQFINLK ddPTM_A459_Selumetinib_30min_R2 3 SPQFINLK 8 0 Q92576-2;Q92576 Q92576-2 PHF3 PHD finger protein 3 1 S(1)PQFINLK;S(1)PQFINLK;S(1)PQFINLK 106.16 0.013847 33640000.0 177314.0 161481.0 180259.0 171483.0 194121.0 156920.8 166002.0 180383.6 126805.6 176754.0 True False 167459.59772418145 173866.07345674702 168661.33219115934 148126.71957532488 169733.7845162412 178535.2158148056 173721.4219267228 180908.48641188754 152170.26324449573 171650.65275795572 0.9755838095198853 1.0129065672818343 0.9825848575652572 0.8629545952510772 0.9888327354955213 1.040107992286856 1.01206385839783 1.0539341593240912 0.8865114160624297 1.0 17.389115818063907 -6.511331251998819 24.90549380361067 1.004043950515793 0.9593355185813673 0.10150202826010202 0.05536054147112506 1195.684828236518 2578844.2973439232 0.017923215056675244 0.01923854214171107 3.080837188687628e-07 6.511331251998819 -0.04470843193442564 S(ph)PQISMSDIDLNLK ddPTM_A459_Selumetinib_30min_R2 3 SPQISMSDIDLNLK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.999)PQIS(0.001)MSDIDLNLK;S(1)PQISMSDIDLNLK;S(0.998)PQIS(0.002)MSDIDLNLK 152.94 0.00037287 7471400.0 21373.5 17363.7 23532.600000000002 25506.0 23396.6 24954.199999999997 31751.2 29117.0 27594.1 22851.100000000002 True False 20185.646434899623 18695.43995690468 22018.538136357594 22032.038799695845 20457.309939742183 28391.41453832646 33227.693713809225 29201.72564942116 33113.691043573286 22191.329368711988 0.9096186217379019 0.8424659760700847 0.9922135700172151 0.9928219456180607 0.9218604978476578 1.279392237688838 1.4973277698567096 1.3159069997218498 1.492190507985563 1.0 14.437708474132691 -6.815909863868711 4.411246492339472 1.3564064766832928 0.9319850105315574 0.6662005239301432 0.13573452454880092 0.11404871511232617 4.559610580983206 0.04589875579436654 0.04126454703609634 1.5278831315371856e-07 6.815909863868711 -0.4244214661517355 S(ph)PQISMSDIDLNLKGPK ddPTM_A459_Selumetinib_30min_R2 1 SPQISMSDIDLNLKGPK 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(1)PQISMSDIDLNLKGPK 116.96 0.0033896 0.0 18328.0 20100.0 19898.0 23168.0 24334.0 15962.0 21104.0 18509.0 14750.0 20747.0 True False 17309.403132797157 21641.605368313434 18617.784343304327 20012.478432970798 21276.945371279842 18160.620611390757 22085.37781678265 18562.858125670107 17700.412149434316 20147.980202820327 0.859113566647945 1.074132749310724 0.9240521459663832 0.9932746722755583 1.0560336647691109 0.9013618451366466 1.09615840369404 0.9213260058232372 0.8785204259311612 1.0 14.298347598082895 -10.602464129828832 4.3265518352596 1.0000021373381278 0.9728899978538036 0.010278738565166923 0.08048884953273892 107864608.33584864 13.546960403256872 3034.845005656211 0.01838390713937228 2.4976746738803443e-11 10.602464129828832 -0.027112139484324227 S(ph)PQLATPGSSHPGEEECR ddPTM_A459_Selumetinib_30min_R2 2 SPQLATPGSSHPGEEECR 18 0 E7EWN3;Q9C0A6;Q9C0A6-2;Q9C0A6-3;H0Y3R4;H7C1F2 E7EWN3 SETD5 SET domain-containing protein 5 1 S(1)PQLATPGSSHPGEEECR;S(1)PQLATPGSSHPGEEECR 176.7 1.4531e-09 13372100.0 28035.0 20603.4 32096.0 36178.0 35210.0 28207.0 25240.0 33476.0 29425.0 28194.0 True False 26476.926932996957 22183.614529627313 30030.97830348257 31250.493989469003 30786.605018606213 32092.258212348017 26413.71001211118 33573.40961774988 35310.822203193544 27379.965963190643 0.9670182559245062 0.8102133713186768 1.0968230692417924 1.1413635075909832 1.1244208652412286 1.1721073085150118 0.9647093808524638 1.2262034826078907 1.2896590978478595 1.0 14.740833032691405 -5.364623105541993 5.3616248443677526 1.133689461879008 0.8902839832168374 0.4936509442294309 0.09680495301252534 0.16792757722396076 7.022142697732386 0.02541370400845699 0.054497362060805174 4.318937252440009e-06 5.364623105541993 -0.24340547866217066 S(ph)PQLSDFGLER ddPTM_A459_Selumetinib_30min_R1 4 SPQLSDFGLER 11 0 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 S(1)PQLSDFGLER;S(1)PQLSDFGLER;S(1)PQLSDFGLER;S(1)PQLSDFGLER 209.22 1.8459e-05 121511300.0 4408.37 4888.17 4616.9 4406.66 5262.200000000001 4506.29 5136.799999999999 4584.27 2433.2 3976.13 True False 4511.076443805192 4315.860783951419 3989.9503388163776 3637.1195542530227 4786.234939116867 4460.960813983955 4749.327040338596 4462.6802677924225 4128.962686103315 4486.505016285976 1.0054767413454397 0.9619649968705886 0.8893226073152467 0.8106799259223625 1.0668069960343016 0.9943064362551036 1.0585805706443163 0.9946896864247181 0.9203071591618006 1.0 12.131376308894527 -6.282377422376043 24.99633909705929 1.007582457445856 0.9181157224422274 0.34454541887256096 0.06004291256845936 989.5452630212562 1181340.0339328018 0.019673917081519908 0.022330578765844798 5.219423992976551e-07 6.282377422376043 -0.08946673500362867 S(ph)PQLSDFGLER ddPTM_A459_Selumetinib_30min_R2 4 SPQLSDFGLER 11 0 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 S(1)PQLSDFGLER;S(1)PQLSDFGLER;S(1)PQLSDFGLER;S(1)PQLSDFGLER 188.63 1.9513e-05 101629500.0 66996.5 70598.5 67199.5 61301.6 77803.0 55464.5 62466.1 56838.4 54232.4 68218.7 True False 63273.10273823902 76013.17794004366 62875.957331283564 52952.21632884163 68028.69157235498 63104.23141839887 65370.89742422893 57003.79033389637 65080.395379863214 66249.04887753126 0.9550794133694869 1.1473851961340984 0.9490846796535415 0.7992902121014551 1.02686291690185 0.9525303757198699 0.9867446934230606 0.8604469241403636 0.9823596939508003 1.0 16.015612121818023 -5.4347119114692335 11.297755734760209 0.9384692014431767 1.0507969354655327 0.23051502832183768 0.07746217626432411 0.8917993812750097 111.2422915011736 0.019462748713894876 0.04052971384856434 3.6752601743413445e-06 5.4347119114692335 0.11232773402235596 S(ph)PQNQYPAELMR ddPTM_A459_Selumetinib_30min_R1 1 SPQNQYPAELMR 12 0 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 S(1)PQNQYPAELMR 139.58 0.0011459 7443000.0 390.54 395.97 426.23 541.63 639.28 356.83 537.08 447.99 311.32 582.07 True False 399.63882214144473 349.6096483185412 368.3503071138003 447.0444881543088 581.4572368740509 353.2406141757173 496.5676231944111 436.10784992339626 528.2873020868335 656.7843543419298 0.6084779874847445 0.5323050800575713 0.5608390405140996 0.6806564212422942 0.8853092084640879 0.5378334788892003 0.7560588493188924 0.6640046265419308 0.8043542733537785 1.0 9.359275949987037 -14.522878743173935 0.0808686858561124 2.1240055051101563 0.33580772063868886 0.592478856077487 0.09514004813187608 181.55598292320303 1.0340778660697736 36.03373237026257 3.2615927598496404 3.000000014550512e-15 14.522878743173935 -1.7881977844714674 S(ph)PQNQYPAELMR ddPTM_A459_Selumetinib_30min_R2 3 SPQNQYPAELMR 12 0 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 S(1)PQNQYPAELMR;S(1)PQNQYPAELMR;S(1)PQNQYPAELMR 110.55 0.007172499999999998 21165200.0 23809.4 26726.5 27995.3 29834.5 34217.3 23136.9 30368.7 26646.300000000003 24253.8 29816.600000000002 True False 22486.168864579922 28776.33661075767 26194.112876977964 25770.98963261685 29918.616867456814 26323.797959133353 31780.904724437452 26723.836321467577 29105.237707793232 28955.717285169536 0.7765709494648516 0.9938049997986498 0.9046266275846669 0.8900138573260683 1.0332542127278075 0.9091053659587914 1.0975692438023255 0.9229208884131122 1.0051637616554667 1.0 14.821560614969403 -3.2732136499627744 0.571874906764713 0.9885233942841639 2.1055383812070385e-32 0.40098555038265227 0.06666899593412408 20.615616350030866 1.3135059205662702 0.03104177009451616 19.75828331786685 0.0005330725873949337 3.2732136499627744 -0.9885233942841639 S(ph)PQPARPGSAAVPGAAFAPIPR ddPTM_A459_Selumetinib_30min_R2 4 SPQPARPGSAAVPGAAFAPIPR 22 1 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.981)PQPARPGS(0.019)AAVPGAAFAPIPR;S(0.999)PQPARPGS(0.001)AAVPGAAFAPIPR;S(0.99)PQPARPGS(0.01)AAVPGAAFAPIPR;S(0.998)PQPARPGS(0.002)AAVPGAAFAPIPR 90.755 0.0002157 42619100.0 60951.4 45087.8 59626.4 57558.299999999996 63472.299999999996 50215.0 51154.3 48725.2 43045.799999999996 59732.9 True False 57563.96519578637 48545.88927987274 55790.10234031565 49718.76024639425 55498.342224438464 57131.66044361525 53533.076310322445 48866.98226510892 51656.16280014374 58008.25597228737 0.9923409044272378 0.8368789660400212 0.961761414909088 0.8570980011904976 0.9567317840231573 0.9848884350343009 0.9228527114467485 0.8424142640739697 0.890496739374853 1.0 15.823970624662694 -4.447804310209819 17.27465358731493 0.9151270967892609 2.5222537503551967 0.13905660097985684 0.056053015529770996 3981362.2092293533 13480353.425072696 0.0137660480071992 238716103.20979196 3.566117837868966e-05 4.447804310209819 1.6071266535659359 S(ph)PQPDPVDTPASTK ddPTM_A459_Selumetinib_30min_R1 1 SPQPDPVDTPASTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(1)PQPDPVDTPASTK 88.133 0.021177 3402900.0 601.65 1238.8 582.4 942.68 632.84 693.42 738.98 518.96 446.78 781.75 True False 615.667274392892 1093.7607200975044 503.3132788942061 778.0586342951893 575.5997337369769 686.4448243749849 683.2381436437886 505.19549498034684 758.1530284798778 882.0952273898394 0.6979601014446931 1.2399576441808817 0.5705883710351017 0.8820574130046037 0.6525369550407876 0.778198093652776 0.7745627937082507 0.5727221724974567 0.859491135354272 1.0 9.78479060141591 -5.277197317422892 24.9988306465657 0.7475195895689999 0.9689589401982122 0.17702432942867963 0.17714913179048425 1020.9172491793084 1619611.140270433 0.0420972437841309 0.08810231424100283 5.282052124106573e-06 5.277197317422892 0.22143935062921227 S(ph)PQPDPVDTPASTK ddPTM_A459_Selumetinib_30min_R2 2 SPQPDPVDTPASTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(1)PQPDPVDTPASTK;S(0.833)PQPDPVDT(0.154)PAS(0.012)T(0.001)K 120.63 0.0022979 3819300.0 26911.0 33594.0 27752.0 16931.1 18513.300000000003 16386.2 24815.4 19647.0 18891.5 23983.0 True False 25415.394353268475 36170.55177826473 25966.466534092957 14625.054972223408 16187.49374299808 18643.250310886553 25969.365270782248 19704.169517264065 22670.327872612783 23290.548474682582 1.0912321099219993 1.5530141687123873 1.1148928743485438 0.6279394831822537 0.6950241537074275 0.8004642025134032 1.1150173341349865 0.8460156933909477 0.9733702878339686 1.0 14.50745699386798 -5.531795509795702 9.407657785794626 0.8602353721445094 1.3253757881939348 0.5434808777381119 0.16997988932734262 0.10629887872650938 89.58106346794308 0.046570755623401586 0.08322693323296892 2.9390331879059068e-06 5.531795509795702 0.46514041604942535 S(ph)PQPPSR ddPTM_A459_Selumetinib_30min_R1 1 SPQPPSR 7 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 S(1)PQPPSR 87.789 0.03313 8005800.0 1339.3 1480.0 1624.5 1581.4 1397.4 1164.8 1543.2 1305.5 879.64 1258.8 True False 1370.50308417585 1306.720911966667 1403.9018227397612 1305.2381765545185 1271.0054167310086 1153.0831695537818 1426.7951815625527 1270.8738991383602 1492.6848336363303 1420.3792417503403 0.9648853235048496 0.9199802936829663 0.9883992820183194 0.9189363926116431 0.894835252002657 0.8118135886953908 1.004517061094406 0.8947426587087095 1.0509058353999088 1.0 10.47206046590193 -8.262895835634778 24.993513765811713 1.0254529254747238 0.9244270468465483 0.3674062762307321 0.052846933464218426 142.6568973331221 2447932.240091504 0.04296879221944097 0.013406240470652881 5.458887753477546e-09 8.262895835634778 -0.10102587862817547 S(ph)PQPPSR ddPTM_A459_Selumetinib_30min_R2 3 SPQPPSR 7 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 S(1)PQPPSR;S(1)PQPPSR;S(1)PQPPSR 96.665 0.022999 695870000.0 153222.6 136021.7 172640.8 175743.4 156644.1 128584.6 164523.9 177225.1 149267.4 167205.6 True False 144707.101290666 146454.1270112997 161533.27888509067 151806.84574572532 136965.0677419783 146295.96147521818 172174.58734792328 177740.79569980514 179125.05087962537 162377.9398756783 0.8911746349378391 0.9019336439631492 0.9947981789199054 0.9348982125401607 0.8434955379212417 0.9009595859340684 1.0603323793844508 1.0946117177979295 1.103136614596596 1.0 17.308996120545174 -7.284978594891824 6.498483245307577 1.0732944528051007 0.912470709792036 0.7413682071376883 0.04425121947529858 0.09611736295077075 16.267632099023764 0.019414481605658045 0.013397153750635953 5.188256096996889e-08 7.284978594891824 -0.16082374301306468 S(ph)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R1 4 SPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 30 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.957)PQPPVEEEDEHFDDT(0.043)VVCLDTYNCDLHFK;S(0.916)PQPPVEEEDEHFDDT(0.084)VVCLDTYNCDLHFK;S(0.963)PQPPVEEEDEHFDDT(0.037)VVCLDTYNCDLHFK;S(0.865)PQPPVEEEDEHFDDT(0.134)VVCLDT(0.001)YNCDLHFK 116.99 7.0699e-16 135948900.0 13929.600000000002 14761.4 9527.3 11283.800000000001 10872.199999999999 10672.099999999999 11472.42 10662.4 7683.83 11155.3 True False 14254.132577716671 13033.128425611327 8233.544989712851 9313.296153159148 9888.811429642814 10564.748363491506 10607.046122901662 10379.598515643693 13038.898305261062 12587.191416823624 1.1324315413734847 1.0354278404149537 0.6541209009269667 0.7399026394967907 0.7856249342824608 0.8393253120287829 0.8426856930708653 0.8246159267722476 1.0358862333525574 1.0 13.619668789608696 -10.048520668695351 13.407764379294324 0.9999999994107843 0.8644637150632469 0.05840338668762146 0.14109937987535875 0.0 0.0 0.14505094622403675 0.03518002190455828 8.9429197028625e-11 10.048520668695351 -0.1355362843475374 S(ph)PQPPVEEEDEHFDDTVVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R2 2 SPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 30 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.982)PQPPVEEEDEHFDDT(0.018)VVCLDTYNCDLHFK;S(0.991)PQPPVEEEDEHFDDT(0.009)VVCLDTYNCDLHFK 91.615 4.2515e-07 16393600.0 50766.0 40273.0 42305.0 57023.0 53363.0 46333.0 49368.0 51833.0 49210.0 49623.0 True False 47944.628952399624 43361.8096018949 39583.14235820134 49256.36902983832 46659.06286872715 52714.95018090259 51663.70982083616 51983.825448584896 59053.37504228225 48190.255053962144 0.9949029922898837 0.8998045259013366 0.8213930869192787 1.0221230199898792 0.9682261033165231 1.0938923257798452 1.0720779494315713 1.078720695509389 1.2254215084804152 1.0 15.55645381632174 -6.532193582723875 1.2576878117035404 1.1056579289669222 0.912359249259504 0.5335845708816176 0.07207264051390266 0.33115057730002956 1.0928717028726782 0.031509789228535236 0.0351549395843694 2.9363405137559484e-07 6.532193582723875 -0.1932986797074182 S(ph)PQQSAALPR ddPTM_A459_Selumetinib_30min_R1 1 SPQQSAALPR 10 0 E5RJN3;A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4 E5RJN3 NCAPH2 Condensin-2 complex subunit H2 1 S(1)PQQSAALPR 116.71 0.0062495 26613000.0 949.77 1033.6 1032.0 685.7 899.4 928.94 681.07 1032.8 736.63 985.74 True False 971.8977930692887 912.5856314923964 891.8600683702273 565.95536718315 818.0494288019672 919.5957070100351 629.6963415673974 1005.4067889927984 1250.0073086734685 1112.269330920703 0.8737971694902179 0.8204718103096357 0.8018382271063542 0.5088294277741788 0.7354778254335311 0.8267743085650141 0.5661365678815884 0.9039238618227053 1.123835094543828 1.0 10.119290457018074 -7.991769257902971 6.727198018564286 1.0480727326948063 0.7338676803402274 0.5804191330886235 0.11280822089736442 0.09732123742287667 22.12302863847217 0.06825137784988995 0.030406259629886256 1.0191327128242163e-08 7.991769257902971 -0.31420505235457885 S(ph)PQQSAALPR ddPTM_A459_Selumetinib_30min_R2 3 SPQQSAALPR 10 0 E5RJN3;A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4 E5RJN3 NCAPH2 Condensin-2 complex subunit H2 1 S(1)PQQSAALPR;S(1)PQQSAALPR;S(1)PQQSAALPR 126.5 0.0034461 97590000.0 79298.6 61562.4 74281.0 61726.0 81713.0 63657.0 74302.5 65181.3 62488.0 75386.0 True False 74891.50126944717 66284.03812568451 69501.84133103763 53318.812316710784 71447.48241651146 72425.1739292884 77757.71347761054 65370.96679165493 74987.34606060015 73209.41030364925 1.0229764310191976 0.905403251450319 0.9493566611555291 0.7283054472855522 0.975933040850488 0.9892877654510795 1.0621273024205 0.8929312027035465 1.0242856177856998 1.0 16.15974148332969 -6.493677223587522 24.993286571647356 0.9903431025751038 0.8985702384950622 0.23446334998754514 0.07936086188059875 1057.8033807040008 905364.1566358762 0.024633029267401255 0.027883903676318093 3.2086531742450326e-07 6.493677223587522 -0.0917728640800416 S(ph)PQQTVPYVVPLSPK ddPTM_A459_Selumetinib_30min_R1 2 SPQQTVPYVVPLSPK 15 0 Q9UQR0;H0Y6S1;B4DRC2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 S(1)PQQTVPYVVPLSPK;S(0.999)PQQT(0.001)VPYVVPLSPK 204.71 5.5718e-06 32964000.0 3761.0 4176.5 3610.9 3783.2 4173.4 3038.8999999999996 3795.8 3372.2000000000003 1748.97 3210.9 True False 3848.623982367933 3687.5134383978248 3120.559613253928 3122.5351394593736 3795.916706873616 3008.331425100433 3509.4797499838874 3282.7583015506502 2967.8743502852685 3623.0502918145626 1.0622607119373975 1.0177925066977132 0.8613072858260082 0.8618525518439569 1.0477129493481239 0.8303311251011493 0.9686533355368372 0.9060758303486091 0.8191645467882377 1.0 11.822989116743072 -5.104830310872615 4.812127145751938 0.9110511763633796 1.0527313876719229 0.3507253735287321 0.07072471160875475 0.21774104317881507 7.737998488717189 0.01745115815636575 0.0511682521081072 7.85542504694184e-06 5.104830310872615 0.14168021130854325 S(ph)PQQTVPYVVPLSPK ddPTM_A459_Selumetinib_30min_R2 2 SPQQTVPYVVPLSPK 15 0 Q9UQR0;H0Y6S1;B4DRC2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 S(1)PQQTVPYVVPLSPK;S(0.998)PQQT(0.002)VPYVVPLSPK 177.07 1.943e-05 23328000.0 124329.0 102130.0 102698.0 120999.0 132358.0 92821.0 95239.0 102792.0 80008.0 97629.0 True False 117419.29190842077 109963.04260029132 96090.52248912779 104518.72746508256 115730.0047444668 105606.25020485539 99667.80221249821 103091.10770186831 96011.83561030106 94810.19709939501 1.2384669107408703 1.1598229511643214 1.0135040895273169 1.102399643315893 1.2206493424240048 1.1138701683548053 1.0512350492005695 1.0873419827805224 1.012674148432012 1.0 16.53275461286686 -1.5228787528922052 0.09163499506282087 0.9164309611517091 1.6576826417325692 0.43847122169431685 0.06048524473374936 169.74457070780917 1.1201831571096499 1.159251539400336 15.808344684377778 0.029999999474190815 1.5228787528922052 0.7412516805808601 S(ph)PQSDPADT(ph)PTNTK ddPTM_A459_Selumetinib_30min_R2 1 SPQSDPADTPTNTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 2 S(1)PQSDPADT(0.984)PT(0.016)NTK 140.28 0.0048987 0.0 25717.0 21670.0 20024.0 20002.0 19597.0 18792.0 17528.0 26855.0 17527.0 23369.0 True False 24287.752093307758 23332.01931996776 18735.677640482758 17277.693094625436 17135.049660597168 21380.42742320856 18343.086731073083 26933.143603915407 21032.889745297325 22694.276250046172 1.0702148782232412 1.02810149409018 0.8255684135529389 0.7613238203439198 0.7550383837670217 0.9421065993750323 0.8082692979043896 1.1867813411260741 0.9267927081505644 1.0 14.470040859139699 -7.744810863145184 24.999971670713325 1.0425903489700643 0.8801541299942643 0.2662763449578438 0.11652699269855317 316.80226330390275 476294.45501423464 0.058440075782156285 0.03361996050535719 1.7996545006873506e-08 7.744810863145184 -0.16243621897579996 S(ph)PQSDPADTPTNTK ddPTM_A459_Selumetinib_30min_R1 1 SPQSDPADTPTNTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.999)PQS(0.001)DPADTPTNTK 103.88 0.0065803 8280000.0 1203.5 4024.3 1274.7 1895.9 1700.6 1639.1 1666.9 1278.2 744.95 1599.3 True False 1231.539208396652 3553.133085153688 1101.6027414258997 1564.8166554506843 1546.7810302653165 1622.6121421837245 1541.1643909711113 1244.297983821257 1264.1257410047108 1804.5857335012083 0.682449819664291 1.9689466780057026 0.6104463317952757 0.8671334514069716 0.8571391214892816 0.8991604621829612 0.8540266956344523 0.6895200159912069 0.7005074447486007 1.0 10.817451970074497 -5.306519734580815 24.99990209791731 0.8071706949504546 1.325701620307844 0.3105754631166878 0.30747198546233956 406.0693876670735 225190.35357616917 0.07325912287507366 0.15250197028414814 4.937194828543104e-06 5.306519734580815 0.5185309253573894 S(ph)PQSDPADTPTNTK ddPTM_A459_Selumetinib_30min_R2 2 SPQSDPADTPTNTK 14 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(1)PQSDPADTPTNTK;S(1)PQSDPADTPTNTK 213.69 1.7893000000000004e-06 13872700.0 67844.0 85133.0 75760.0 41218.0 45527.0 45219.0 50303.0 50034.0 41782.0 79226.0 True False 64073.50208105036 91662.42735426007 70885.68408125133 35604.037294984024 39807.491243455996 51447.5067927878 52642.18917350351 50179.59065642542 50139.56748662139 76938.53952613108 0.8327881251149655 1.1913720733304047 0.92132869323801 0.4627594637781189 0.5173933829343869 0.6686831737339436 0.6842109233906675 0.6522035765883317 0.6516833799476035 1.0 16.231418823709504 -5.596148490650958 6.417582880293433 0.6442542762425272 1.02291170352728 0.4716711662921792 0.1558304059809644 0.14759819663960322 10.090369249978062 0.04049459272457975 0.07094068195544878 2.5342619868531383e-06 5.596148490650958 0.3786574272847527 S(ph)PQTLAPVGEDAMK ddPTM_A459_Selumetinib_30min_R1 2 SPQTLAPVGEDAMK 14 0 Q92797 Q92797 SYMPK Symplekin 1 S(0.956)PQT(0.044)LAPVGEDAMK;S(0.996)PQT(0.004)LAPVGEDAMK 205.78 8.1821e-06 54066000.0 3990.6000000000004 5684.0 3384.1 3175.4 3364.3 4046.3 4568.0 5242.5 2126.06 4502.3 True False 4083.573215644106 5018.51463758009 2924.5578075307026 2620.8759996403287 3059.999659015407 4005.59789574645 4223.432082282104 5103.451869960055 3607.7685387213583 5080.214061115796 0.803819123863298 0.9878549559539319 0.5756760979651251 0.5158987334216171 0.6023367563262328 0.7884702982115439 0.8313492367592258 1.0045741790729101 0.7101607324650734 1.0 12.31067357268389 -7.175755371826349 2.7243391664388685 0.8918397606410096 0.6974701719950722 0.2692551900844996 0.14637730518164893 0.43143941661782004 6.2481857415008255 0.06957845424410171 0.049948988726932174 6.671824720566606e-08 7.175755371826349 -0.19436958864593734 S(ph)PQTLAPVGEDAMK ddPTM_A459_Selumetinib_30min_R2 4 SPQTLAPVGEDAMK 14 0 Q92797 Q92797 SYMPK Symplekin 1 S(0.996)PQT(0.004)LAPVGEDAMK;S(1)PQTLAPVGEDAMK;S(0.999)PQT(0.001)LAPVGEDAMK;S(0.998)PQT(0.002)LAPVGEDAMK 189.52 9.7674e-05 76816500.0 244140.0 180076.0 262935.0 268050.0 262862.0 221759.0 273141.0 287997.0 221067.0 228568.0 True False 230571.6761698547 193887.25016439828 246018.04836198274 231541.12758795856 229838.92554390413 252304.28932222814 285842.5977186235 288835.0235895301 265286.577128068 221968.64794901622 1.0387578529685622 0.8734893506624056 1.1083459336946109 1.0431253680526136 1.0354567082676271 1.1366663339778493 1.2877611336546884 1.3012424333722676 1.1951533677359762 1.0 17.759996391360424 -6.886052466693287 2.882316383402547 1.2210020876631398 1.0156728568230942 0.42483409244456327 0.09552166358021015 0.2227236453810558 3.729963033370677 0.03606402006683514 0.0312123065580549 1.3000125153006285e-07 6.886052466693287 -0.20532923084004562 S(ph)PQVKPASTMGMGPLGK ddPTM_A459_Selumetinib_30min_R1 2 SPQVKPASTMGMGPLGK 17 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 S(1)PQVKPASTMGMGPLGK;S(1)PQVKPASTMGMGPLGK 100.21 0.0024628 101143000.0 2607.0 3401.2 2670.46 2696.22 2526.96 2384.45 3029.9 2956.0 1912.72 2969.3 True False 2667.7380276610493 3002.985922825019 2307.8261997867803 2225.3757913177064 2298.396914171024 2360.464597907378 2801.3522036135164 2877.5972775587825 3245.7461404584624 3350.438578431274 0.7962354674503911 0.8962963661405374 0.6888131645342203 0.6642043240678243 0.6859988208609895 0.7045240623430808 0.8361150750971689 0.8588718193742018 0.9687526168523793 1.0 11.71013424396771 -7.940249059362137 1.415896305873794 0.9947711195408729 0.7402086225093618 0.6737277321595594 0.06623325112441622 0.2864231796175045 1.0336730745733003 0.0658122210585709 0.022825319788525564 1.1474953666941577e-08 7.940249059362137 -0.2545624970315111 S(ph)PQVKPASTMGMGPLGK ddPTM_A459_Selumetinib_30min_R2 2 SPQVKPASTMGMGPLGK 17 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 S(1)PQVKPASTMGMGPLGK;S(1)PQVKPASTMGMGPLGK 103.88 0.0016530999999999998 130974000.0 150642.0 125654.0 141115.0 170960.0 177538.0 136663.0 146610.0 145944.0 149637.0 140871.0 True False 142269.92070770555 135291.2577587093 132035.81453439526 147674.9530775503 155234.08923014218 155487.0877468047 153427.65550220376 146368.67287767006 179568.58120711206 136803.68820318594 1.0399567626890363 0.9889445199589187 0.9651480619315669 1.0794661680335544 1.134721521539556 1.1365708760415105 1.1215169526301607 1.0699175935978995 1.312600439108119 1.0 17.06174759998752 -5.964565746141573 3.7640271145414568 1.1316726717634857 0.9976639641190665 0.37433048716556905 0.07560923976584769 0.22469050826896705 6.834755416577845 0.021185352077977962 0.03156418455447867 1.085011281588495e-06 5.964565746141573 -0.1340087076444192 S(ph)PRPDHPGTPPHK ddPTM_A459_Selumetinib_30min_R2 1 SPRPDHPGTPPHK 13 1 P30291 P30291 WEE1 Wee1-like protein kinase 1 S(1)PRPDHPGTPPHK 55.975 0.046667 2048500.0 9819.0 9125.0 11843.0 11937.0 10925.0 8681.8 9834.7 10707.0 9163.7 8110.1 True False 9273.299288571323 9824.858158500503 11081.03427368344 10311.160007526432 9552.503829260799 9877.639144466371 10292.03303708835 10738.155597360734 10996.696055170938 7875.940340429603 1.1774212205453933 1.2474520798572473 1.406947462108253 1.309197322711563 1.2128715323330834 1.2541536270610683 1.306768791055489 1.3634125111687945 1.3962391257233813 1.0 12.943236467652145 -4.991521518969276 8.644872441976807 1.294970408924549 1.194098194859893 0.062393265990166036 0.1111371582933685 0.33604732080408756 212.40382589071604 0.02640566838059553 0.09426232023819298 1.0197142327094594e-05 4.991521518969276 -0.10087221406465607 S(ph)PRPPPR ddPTM_A459_Selumetinib_30min_R1 1 SPRPPPR 7 1 Q9HB15 REV__H3BV60 KCNK12 Potassium channel subfamily K member 12 1 S(1)PRPPPR 76.847 0.028373 77603000.0 301.4 315.76 336.55 405.31 282.59 446.92 476.21 403.56 122.1 328.91 True False 308.42203357769097 278.7906724071585 290.8483585368217 334.53021711098495 257.0297843953168 442.42439057089274 440.2890963011295 392.8562778523756 207.19478216883715 371.1288023547066 0.8310377195756324 0.7511965404956745 0.7836857627095275 0.9013857587675383 0.6925622122684524 1.1921047026364862 1.1863511899578274 1.058544298798192 0.5582826793669617 1.0 8.535776159017784 -6.749060023936407 24.998868117366143 1.0144215311444993 0.7953262290086115 0.2632916612153121 0.17219640444461573 317.1720304613219 640496.1061662325 0.0587938571951958 0.05839520591377495 1.7821324415071646e-07 6.749060023936407 -0.2190953021358878 S(ph)PRPTGSDLLPGAPILSLR ddPTM_A459_Selumetinib_30min_R1 2 SPRPTGSDLLPGAPILSLR 19 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 S(0.992)PRPT(0.006)GS(0.002)DLLPGAPILSLR;S(0.998)PRPT(0.002)GSDLLPGAPILSLR 133.41 0.00012506 28025000.0 2412.2 3124.8 2967.8999999999996 2576.3 3372.5 2536.6 3387.7 2845.4 1667.1 3105.7 True False 2468.399566675866 2758.946963319891 2564.8754815077486 2126.397568140511 3067.4579704632356 2511.084107048523 3132.1630615470817 2769.9307488382146 2828.946939833484 3504.346847079786 0.7043822071245067 0.7872927777166105 0.7319125627205223 0.6067885574490046 0.8753294420668961 0.7165626624947354 0.8937936791722402 0.7904271094473513 0.8072679626992058 1.0 11.774929859200931 -11.403089480553176 0.15400731929272468 1.3153655108177338 0.6662995047755473 0.5409269509772849 0.07173869490783015 31.675318987539484 0.7321248057070419 4.031518323831223 0.4099077314863263 3.952851684700702e-12 11.403089480553176 -0.6490660060421864 S(ph)PRPTGSDLLPGAPILSLR ddPTM_A459_Selumetinib_30min_R2 2 SPRPTGSDLLPGAPILSLR 19 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 S(0.992)PRPT(0.008)GSDLLPGAPILSLR;S(0.967)PRPT(0.026)GS(0.006)DLLPGAPILSLR 122.39 0.00023153 7814500.0 18116.2 16273.8 21974.0 20491.0 24447.0 18189.9 15715.1 18443.8 17625.6 19595.2 True False 17109.37412889459 17521.948131485533 20560.216763482218 17700.09045105338 21375.74930104702 20695.39361352817 16445.88328887989 18497.468404464536 21151.2125004115 19029.43566155611 0.8991004480211418 0.9207812802816822 1.080442800782508 0.9301426887194393 1.1232991708856093 1.0875463666711715 0.8642338943400409 0.9720450324143732 1.111499724773335 1.0 14.215945157117938 -5.126430259450863 6.446714196386451 1.01714126815279 0.9046667792293887 0.24083358979204006 0.07904807225177884 0.3390175745958942 16.009555041344097 0.020607483997945847 0.056246686247672886 7.474286492997874e-06 5.126430259450863 -0.1124744889234014 S(ph)PSAGDVHILTGFAK ddPTM_A459_Selumetinib_30min_R2 1 SPSAGDVHILTGFAK 15 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 S(0.808)PS(0.192)AGDVHILTGFAK 117.08 0.0021826000000000003 4409100.0 11799.0 9826.8 16793.0 17311.0 15601.0 13409.0 12952.0 14019.0 15549.0 11793.0 True False 11143.258815139336 10580.483961857828 15712.556662835943 14953.21193685936 13641.062905290415 15255.9680352173 13554.293663901119 14059.792969029608 18659.234475359608 11452.505448106225 0.9729974690369585 0.9238575794441037 1.3719754803027975 1.305671671986151 1.191098573766327 1.3321074680422886 1.1835221319316154 1.227660884575656 1.629270953845744 1.0 13.483375628714382 -5.254809272539017 24.848281466966426 1.284427938004702 0.9484274786043305 0.4296695180794067 0.15281603275339586 418.2462261333581 1567489.2173179502 0.03716363437178723 0.09363647771851559 5.5614844525097935e-06 5.254809272539017 -0.3360004594003714 S(ph)PSAGILR ddPTM_A459_Selumetinib_30min_R1 1 SPSAGILR 8 0 F5GX58;F8WDL1;Q99618;J3KMY0 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 S(0.998)PS(0.002)AGILR 91.265 0.027107 11807000.0 1528.6 1637.1 1977.8 1595.5 1875.5 1429.2 1609.9 1679.7 1115.3 1533.4 True False 1564.2134058621702 1445.4275709328576 1709.225623277748 1316.875876244298 1705.8613561464185 1414.8235456097732 1488.4639468620742 1635.1488995654554 1892.5826417109265 1730.2268265808486 0.9040510653468815 0.8353977344052681 0.9878621675606534 0.7611001378626262 0.985917759417371 0.8177098654779541 0.8602709910604444 0.9450488655274872 1.0938349889366321 1.0 10.756745467109226 -8.038911029118212 4.116892647205873 1.0443210308699058 0.8793407836257449 0.47830012684971945 0.06961020689066977 0.1758225011519081 6.371968694954638 0.04530973356176358 0.016881960183402968 9.143005286585643e-09 8.038911029118212 -0.16498024724416094 S(ph)PSAGILR ddPTM_A459_Selumetinib_30min_R2 3 SPSAGILR 8 0 F5GX58;F8WDL1;Q99618;J3KMY0 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 S(0.993)PS(0.007)AGILR;S(0.998)PS(0.002)AGILR;S(0.997)PS(0.003)AGILR 100.25 0.017997 40375900.0 22919.199999999997 20613.1 22808.1 32410.0 24459.9 23261.7 25351.2 26418.9 17921.7 19499.4 True False 21645.44261682698 22194.058488436884 21340.65167758163 27995.70208963154 21387.028687719558 26465.78802631176 26530.081032449794 26495.774625115664 21506.54077413676 18936.40165647441 1.1430599651136117 1.1720314604146915 1.126964460551839 1.4784066475512117 1.1294135536255523 1.3976144204389027 1.401009627580385 1.3991979630436644 1.135724788916463 1.0 14.20887459179388 -5.658205183947207 19.2928979793779 1.2984414926311096 1.1497701897951877 0.13447748083038968 0.14425211288988518 4.026872039780542 738.7971087151886 0.037073117794985413 0.06421256202156893 2.196821731455521e-06 5.658205183947207 -0.1486713028359219 S(ph)PSAIPEQNHSLNDQAK ddPTM_A459_Selumetinib_30min_R1 3 SPSAIPEQNHSLNDQAK 17 0 Q13129 Q13129 RLF Zinc finger protein Rlf 1 S(0.978)PS(0.022)AIPEQNHSLNDQAK;S(0.931)PS(0.069)AIPEQNHSLNDQAK;S(0.781)PS(0.219)AIPEQNHSLNDQAK 146.86 0.00041253 26038100.0 4146.91 5224.200000000001 5707.4 5159.7 4731.24 4594.2 5156.5 4749.99 2449.76 4252.24 True False 4243.524934517793 4612.548235335313 4932.366428504107 4258.655254564529 4303.300177368265 4547.986519199848 4767.541053478031 4624.0048350579955 4157.063796608767 4798.056424325126 0.8844258089596495 0.9613368054511977 1.0279925853931309 0.8875792358285018 0.896884029031307 0.9478809995110777 0.9936400558583705 0.9637245638911778 0.8664057753746575 1.0 12.228234408240787 -6.990519763701386 24.893073998199974 0.9554683485656134 0.9348164549423431 0.04545727613598516 0.05199520702582929 899.2692957702982 2361274.814022494 0.019087691977332632 0.016816698938126005 1.0220690476280561e-07 6.990519763701386 -0.020651893623270245 S(ph)PSAIPEQNHSLNDQAK ddPTM_A459_Selumetinib_30min_R2 3 SPSAIPEQNHSLNDQAK 17 0 Q13129 Q13129 RLF Zinc finger protein Rlf 1 S(0.649)PS(0.351)AIPEQNHSLNDQAK;S(0.5)PS(0.5)AIPEQNHSLNDQAK;S(0.5)PS(0.5)AIPEQNHSLNDQAK 112.3 0.0012811 54473700.0 127071.0 136818.0 144566.0 145805.0 133145.0 110980.0 129823.0 126698.0 109435.0 134170.0 True False 120008.90252551645 147311.50066079115 135264.78095155934 125946.10747234583 116418.13476859768 126266.48762386569 135860.0267393943 127066.67020401706 131325.0578693796 130296.16348447524 0.9210470923790129 1.1305897021161584 1.0381332599073503 0.9666140898104976 0.8934885851989716 0.9690729507850038 1.0427016660055535 0.975214210502499 1.0078965823504615 1.0 16.991435079421848 -5.754393641855329 24.002713698703452 0.9768934019712217 1.0399900260505572 0.12492776112943815 0.059423074555915244 171.79207234544907 585231.3508542111 0.016295873435129286 0.027430431215668474 1.7603797256844413e-06 5.754393641855329 0.06309662407933558 S(ph)PSAMQQQDGLDR ddPTM_A459_Selumetinib_30min_R2 1 SPSAMQQQDGLDR 13 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47;O60343-4;O60343-5 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 S(0.974)PS(0.026)AMQQQDGLDR 98.898 0.012182 8587500.0 23501.0 19324.0 29540.0 32472.0 33744.0 24521.0 27703.0 29148.0 24119.0 26357.0 True False 22194.908501956885 20806.0886635467 27639.42856072016 28049.25758267559 29504.777044812512 27898.54517052452 28991.2443924531 29232.81585428882 28943.473941166543 25596.004926289836 0.8671239346090428 0.8128646921057833 1.0798336943720273 1.0958451392492896 1.1527102424686577 1.0899570167635704 1.1326472422528717 1.1420851003299968 1.130780917745429 1.0 14.643631028727505 -5.3114062858268385 4.83342506339112 1.1122047254829093 0.8387420398339641 0.855284927475302 0.04323169265864294 0.05815372280132858 3.061843075007143 0.01077424799926537 0.024280746400529962 4.881954350651382e-06 5.3114062858268385 -0.27346268564894516 S(ph)PSAPAATSSASSSTSSYK ddPTM_A459_Selumetinib_30min_R1 2 SPSAPAATSSASSSTSSYK 19 0 A0A087X0S7;A0A0C4DH00;A0A087WTU1;A0A0B4J2G4;Q15345-3;Q15345 A0A087X0S7 LRRC41 Leucine-rich repeat-containing protein 41 1 S(0.995)PS(0.005)APAATSSASSSTSSYK;S(1)PSAPAATSSASSSTSSYK 206.62 2.5043e-16 58424000.0 4876.2 6319.299999999999 6109.1 6716.900000000001 5546.4 5021.1 5008.5 5403.9 2653.04 4544.5 True False 4989.805972566477 5579.4334182371285 5279.517774884259 5543.919506828787 5044.729099296451 4970.592292794035 4630.7048126335185 5260.571017658964 4502.015109624996 5127.8308421786 0.9730831858810924 1.088068930110546 1.0295811108779114 1.0811432119070077 0.9837939773288539 0.9693362448520706 0.9030533485121999 1.0258862235447628 0.8779570247508942 1.0 12.324132955515916 -6.476771748905738 3.762741119747086 0.9546890598076172 1.0450893903115637 0.4094200582256615 0.04959145946728211 0.21668464817261276 6.321382689851124 0.015217212523479387 0.016695547154639043 3.336016969296021e-07 6.476771748905738 0.09040033050394647 S(ph)PSAPAATSSASSSTSSYK ddPTM_A459_Selumetinib_30min_R2 4 SPSAPAATSSASSSTSSYK 19 0 A0A087X0S7;A0A0C4DH00;A0A087WTU1;A0A0B4J2G4;Q15345-3;Q15345 A0A087X0S7 LRRC41 Leucine-rich repeat-containing protein 41 1 S(0.945)PS(0.055)APAATSSASSSTSSYK;S(0.992)PS(0.008)APAATSSASSSTSSYK;S(1)PSAPAATSSASSSTSSYK;S(0.988)PS(0.012)APAATSSASSSTSSYK 256.67 4.1426e-47 61122000.0 64199.8 59611.4 69737.0 68895.7 77069.5 56863.4 64839.6 65898.1 57744.7 62045.8 True False 60631.83212816186 64183.40269913828 65250.197343904605 59511.9868082884 67387.34039992826 64695.81719544895 67854.7698772299 66089.8525609823 69295.25352172484 60254.37653965143 1.0062643680042402 1.0652073158022188 1.0829121649108027 0.9876790737204876 1.1183808425199266 1.073711502978954 1.1261384446086984 1.0968473388400382 1.1500451502659546 1.0 15.878778413966549 -6.285041023903392 24.941336828017167 1.0996033579345448 1.0410220079425816 0.2788876369656136 0.04537969971626314 978.1127654923703 1033630.306760537 0.013350694418327239 0.015146917204294305 5.187510348582705e-07 6.285041023903392 -0.05858134999196318 S(ph)PSAPAATSSASSSTSSYKR ddPTM_A459_Selumetinib_30min_R1 3 SPSAPAATSSASSSTSSYKR 20 1 A0A087X0S7;A0A0C4DH00;A0A087WTU1;A0A0B4J2G4;Q15345-3;Q15345 A0A087X0S7 LRRC41 Leucine-rich repeat-containing protein 41 1 S(0.995)PS(0.005)APAATSSASSSTSSYKR;S(0.5)PS(0.5)APAATSSASSSTSSYKR;S(0.782)PS(0.217)APAAT(0.001)SSASSSTSSYKR 138.05 4.5394e-05 19336500.0 3664.5 3908.2200000000003 4218.26 4829.42 4774.3 3647.71 4300.97 3985.3600000000006 2108.96 3414.8 True False 3749.875720124249 3450.6437855178165 3645.4434612436007 3986.052456441078 4342.465407971127 3611.0173492556846 3976.5443701691893 3879.655306526274 3578.7510876559436 3853.1228429687517 0.9732043002384649 0.8955447116913529 0.9461010224202615 1.0344991890707296 1.1269989525237527 0.937166422255427 1.0320315578377315 1.0068859635778131 0.9287923675173018 1.0 11.911812466537231 -5.6675548957566875 5.754496703325779 1.0124272203731548 0.9316478770890958 0.26149994196703485 0.05471244159868975 0.264883601257751 13.137833002108636 0.015181317654172423 0.02653010232410648 2.150032893380972e-06 5.6675548957566875 -0.080779343284059 S(ph)PSAPAATSSASSSTSSYKR ddPTM_A459_Selumetinib_30min_R2 2 SPSAPAATSSASSSTSSYKR 20 1 A0A087X0S7;A0A0C4DH00;A0A087WTU1;A0A0B4J2G4;Q15345-3;Q15345 A0A087X0S7 LRRC41 Leucine-rich repeat-containing protein 41 1 S(0.944)PS(0.056)APAATSSASSSTSSYKR;S(0.515)PS(0.485)APAATSSASSSTSSYKR 151.01 6.3761e-06 32263000.0 29994.0 28525.0 34471.0 35836.0 41276.0 26677.0 21910.9 25199.6 20583.6 29101.0 True False 28327.0535554953 30712.77577766869 32253.173389187035 30955.07497945191 36090.53986787818 30351.51460030515 22929.800265624686 25272.926663981638 24700.895153837057 28260.778516521612 1.0023451243190253 1.0867632595370156 1.1412698121649911 1.0953369512221744 1.2770539865623018 1.0739801305389116 0.8113647772378115 0.8942756707571506 0.8740344905713265 1.0 14.786513588549491 -7.139685272516273 5.415186066863238 0.8873781479883981 1.1232648350722236 0.6572666219008112 0.0774156924668995 0.13696089169516282 5.505017824145144 0.030300715106334097 0.023361056774377637 7.249611395340045e-08 7.139685272516273 0.23588668708382554 S(ph)PSASSLSSMSSVASSVSSR ddPTM_A459_Selumetinib_30min_R2 2 SPSASSLSSMSSVASSVSSR 20 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0;F5H0N7 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 S(1)PSASSLSSMSSVASSVSSR;S(0.959)PS(0.04)AS(0.001)SLSSMSSVASSVSSR 266.39 3.4184999999999994e-49 9447300.0 11731.7 7577.5 10820.1 12328.3 13740.7 6235.4 10598.0 6968.6 9242.599999999999 9220.5 True False 11079.699079716087 8158.669884497268 10123.946546034134 10649.164272496282 12014.470422583427 7094.269750674468 11090.827999538606 6988.8774722861635 11091.378259821133 8954.280207263933 1.2373634533714906 0.9111474842923447 1.1306265061731415 1.1892819998929023 1.3417572540154585 0.7922769431449578 1.2386063137203873 0.7805068984346294 1.2386677659275764 1.0 13.128361750022693 -6.7551951885907435 24.999992922261168 1.0105804401586995 1.1478658390283552 0.15547865748636858 0.1756057313552531 317.8552159072064 1272602.1908424627 0.05616497833135529 0.054824318020610954 1.7571337132080354e-07 6.7551951885907435 0.13728539886965563 S(ph)PSASSLSSMSSVASSVSSRPSR ddPTM_A459_Selumetinib_30min_R2 1 SPSASSLSSMSSVASSVSSRPSR 23 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0;F5H0N7 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 S(0.546)PS(0.453)AS(0.001)SLSSMSSVASSVSSRPSR 106.02 1.1411e-05 12618000.0 1632.6 0.0 0.0 2126.7 1158.8 0.0 0.0 0.0 0.0 1209.1 True False 1541.8666278156184 0.0 0.0 1837.03979123787 1013.2211841965604 0.0 0.0 0.0 0.0 1174.1901413809248 1.3131319821867025 0.0 0.0 1.5645164496760213 0.8629106551728886 0.0 0.0 0.0 0.0 1.0 10.197450333498105 -6.763077614043794 24.987855902351313 0.12499995102528585 0.7103441244778294 0.19507777188219277 0.5434650908330173 72.21737690056185 1101511.7888865883 0.1909438319660681 0.17727815547982603 1.7255294899846732e-07 6.763077614043794 0.5853441734525435 S(ph)PSDSGYSYETIGK ddPTM_A459_Selumetinib_30min_R1 4 SPSDSGYSYETIGK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(1)PSDSGYSYETIGK;S(0.611)PS(0.389)DSGYSYETIGK;S(0.994)PS(0.006)DSGYSYETIGK;S(0.992)PS(0.008)DSGYSYETIGK 281.6 1.0998e-54 505711000.0 14690.7 18285.800000000003 10332.3 9111.0 13042.2 11328.099999999999 16496.0 15437.2 7496.1 14277.2 True False 15032.96472687386 16144.890035162214 8929.230411261338 7519.934884651706 11862.535312787431 11214.149599091843 15251.693438994216 15027.755308907452 12720.334206517768 16109.817691704773 0.9331554841005183 1.0021770788551816 0.5542725921634206 0.466792053675682 0.7363544106955139 0.6961065490434571 0.9467328389971527 0.9328321149559319 0.7896013753816525 1.0 13.97565254728967 -7.260080716619934 24.613046001024436 0.9116942629997098 0.723916843544652 0.25446471726347775 0.15537345269198988 161.1368868781307 2919135.4301049616 0.06876572787698625 0.050301964308543376 5.494387473929271e-08 7.260080716619934 -0.18777741945505777 S(ph)PSDSGYSYETIGK ddPTM_A459_Selumetinib_30min_R2 3 SPSDSGYSYETIGK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.999)PS(0.001)DSGYSYETIGK;S(0.929)PS(0.071)DSGYSYETIGK;S(0.993)PS(0.007)DSGYSYETIGK 241.41 1.2543e-19 467360000.0 223178.0 140675.0 196818.0 234589.0 227854.0 213049.0 263205.0 275473.0 237670.0 185164.0 True False 210774.66021232013 151464.32015858172 184154.94415923563 202637.57351140314 199228.94347939518 242394.56588373584 275444.5540308131 276274.58082299 285210.6410546473 179817.8342061513 1.1721565947161754 0.8423209011901243 1.0241194649698209 1.1269047611767486 1.1079487435656137 1.348000697226971 1.5317977510230214 1.5364136824507424 1.5861087545280346 1.0 17.45617658786327 -6.7549199748041096 2.048950024965349 1.4604379927088285 1.026022137071148 0.49264801772715694 0.1744888109313744 0.23403347498235563 2.0227206136736195 0.06663110971736468 0.061518251190376 1.7582475672881644e-07 6.7549199748041096 -0.4344158556376805 S(ph)PSDSSTASTPVAEQIER ddPTM_A459_Selumetinib_30min_R1 2 SPSDSSTASTPVAEQIER 18 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 S(0.982)PS(0.018)DSSTASTPVAEQIER;S(0.992)PS(0.008)DSSTASTPVAEQIER 240.34 7.3515e-19 119336000.0 2127.46 2626.2 1808.7800000000002 1702.8600000000001 1956.54 1988.7599999999998 2240.35 2417.15 826.99 2451.01 True False 2177.025678683458 2318.723283112744 1563.1576109173457 1405.4874676410948 1779.5713024551937 1968.7548800496024 2071.3585957838677 2353.039329990261 1403.341629040186 2765.6210083591563 0.7871742628882791 0.8384096288335773 0.5652103474021437 0.5081995918431972 0.6434617386389517 0.7118671987589743 0.7489669009322449 0.8508177088900262 0.5074236942800738 1.0 11.43338775249438 -7.0786602012334665 3.0343516167110147 0.7643081326152588 0.6639844662558729 0.10748320594978567 0.144722739671896 0.7240299919654063 12.962244936803787 0.06087815011918477 0.04686914491161724 8.343337250081889e-08 7.0786602012334665 -0.10032366635938583 S(ph)PSDSSTASTPVAEQIER ddPTM_A459_Selumetinib_30min_R2 4 SPSDSSTASTPVAEQIER 18 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 S(0.973)PS(0.027)DSSTASTPVAEQIER;S(0.912)PS(0.087)DS(0.001)STASTPVAEQIER;S(0.992)PS(0.007)DS(0.001)STASTPVAEQIER;S(0.635)PS(0.16)DS(0.121)S(0.054)T(0.025)AS(0.004)T(0.001)PVAEQIER 281.49 4.5118999999999994e-67 210229000.0 37623.4 25720.6 29246.2 42799.6 46197.9 34920.6 40565.7 41398.2 40569.8 32356.2 True False 35532.442046403376 27693.28731523593 27364.531332854913 36970.22064657187 40394.10678753388 39730.5956723551 42452.085429409635 41518.66190815904 48684.89361492346 31421.99243449628 1.1308144167011664 0.8813345421353094 0.8708719343593588 1.176571496019601 1.2855361375234649 1.2644199999468306 1.3510309862720256 1.3213249285420312 1.5493891329906662 1.0 14.939487042811459 -5.970142791071246 3.370138422042379 1.3102616985192614 0.9541584930698481 0.5190226881706784 0.14270983316706448 0.17479462974001458 4.157265083551856 0.041193790995596745 0.06161266097240122 1.0711670598241786e-06 5.970142791071246 -0.3561032054494133 S(ph)PSEAADEVCALEEKEPQK ddPTM_A459_Selumetinib_30min_R1 1 SPSEAADEVCALEEKEPQK 19 1 Q9H6Z4;Q9H6Z4-3;K7EN31 Q9H6Z4 RANBP3 Ran-binding protein 3 1 S(0.759)PS(0.241)EAADEVCALEEKEPQK 103.4 0.00055151 4902500.0 950.6 1063.0 651.64 459.16 674.37 540.3 992.58 1292.4 493.91 1086.2 True False 972.7471304543901 938.5434658247076 563.1508672023014 378.976325500678 613.3733525696937 534.8650725531488 917.7088914692573 1258.1213536931568 838.1291962408715 1225.6243504839686 0.7936747748772097 0.765767639533353 0.45948080827533094 0.30921083230031265 0.5004578705763212 0.4364021262648249 0.7487684877563643 1.0265146520598714 0.6838385643283891 1.0 10.259301150527707 -7.481062370767363 4.964631546392522 0.8926696418615199 0.5396054015961534 0.5023766882932339 0.1615724930563374 0.18202506859847314 10.70940873581412 0.07796792461766487 0.04950283723765163 3.303220987525925e-08 7.481062370767363 -0.3530642402653664 S(ph)PSEAADEVCALEEKEPQK ddPTM_A459_Selumetinib_30min_R2 1 SPSEAADEVCALEEKEPQK 19 1 Q9H6Z4;Q9H6Z4-3;K7EN31 Q9H6Z4 RANBP3 Ran-binding protein 3 1 S(0.5)PS(0.5)EAADEVCALEEKEPQK 81.346 0.0031804000000000003 3260800.0 17217.0 14788.0 12430.0 16507.0 16641.0 12204.0 17731.0 18286.0 16270.0 13114.0 True False 16260.14806511177 15922.192049085534 11630.267332760724 14258.718123836717 14550.408807572445 13884.990223118199 18555.526633309957 18339.20923258974 19524.4546217828 12735.364745736038 1.2767712892208976 1.250234474392772 0.9132260885307337 1.1196159991107217 1.1425199904418997 1.0902703220782954 1.457007867758368 1.4400223000075392 1.5330895511508482 1.0 13.63655265909316 -7.25808435738721 24.966943048678818 1.3941984596039279 1.1274323139158786 0.30474873321926466 0.16299220099935044 305.08591865655677 2270356.3523205686 0.06257918317668791 0.04642079459600044 5.5197021413861805e-08 7.25808435738721 -0.26676614568804924 S(ph)PSEARQDVDLCLVSSCEYK ddPTM_A459_Selumetinib_30min_R1 2 SPSEARQDVDLCLVSSCEYK 20 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.815)PS(0.185)EARQDVDLCLVSSCEYK;S(0.721)PS(0.279)EARQDVDLCLVSSCEYK 143.58 2.2142e-05 31396000.0 2167.73 1625.16 6342.7 5949.299999999999 4942.5 3042.3999999999996 2491.0 2483.9 2068.05 1330.4699999999998 True False 2218.2338913316794 1434.8855116836128 5481.396177957213 4910.366437192229 4495.45174766925 3011.7962182781785 2303.101864484394 2418.0189031557024 3509.3298056041262 1501.248784375258 1.4775924646325649 0.9557946201973031 3.651224390658398 3.270854563413131 2.9944748628322944 2.006193943085544 1.5341240495610629 1.6106716810178512 2.3376070922612118 1.0 10.551947362382174 -6.978698747722418 8.37535025929252 1.684849132087697 2.4975406521700694 0.19608471949959705 0.8072600512955963 0.38915293369685294 127.35686394557703 0.31671869186062546 0.27593602956325985 1.050270705766395e-07 6.978698747722418 0.8126915200823723 S(ph)PSELFAQHIVTIVHHVK ddPTM_A459_Selumetinib_30min_R1 2 SPSELFAQHIVTIVHHVK 18 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.706)PS(0.294)ELFAQHIVTIVHHVK;S(0.5)PS(0.5)ELFAQHIVTIVHHVK 147.7 0.00011108 25969500.0 4546.9 5322.4 4518.7 4650.4 4942.6 4323.3 4457.2 4443.7 2154.23 3647.4 True False 4652.833923272737 4699.250933683368 3905.08535944239 3838.2949388194843 4495.542702686903 4279.811527242326 4120.989815487695 4325.838640828136 3655.5709712659614 4115.579318684615 1.1305416717760732 1.1418200379103132 0.9488543548932253 0.9326256746878216 1.0923231833431724 1.0399050038501507 1.001314637960813 1.0510886331819556 0.8882275587958594 1.0 12.006879806771304 -5.249557654887801 24.839755259649607 0.9992955101059023 1.1361808819897963 0.4971442951381373 0.056902768513341945 591.8978260942583 1237406.5070585434 0.014774081988435552 0.03840379372904934 5.629143825742362e-06 5.249557654887801 0.13688537188389394 S(ph)PSFASEWDEIEK ddPTM_A459_Selumetinib_30min_R1 2 SPSFASEWDEIEK 13 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.765)PS(0.235)FASEWDEIEK;S(0.718)PS(0.275)FAS(0.007)EWDEIEK 230.36 4.2396999999999996e-13 45906900.0 1843.9 2169.4 2766.6 2502.2 2380.9 2162.62 2427.09 2465.5 1409.91 1923.17 True False 1886.8592823951694 1915.4056394733007 2390.910915846 2065.2377421112396 2165.548015382036 2140.866006301852 2244.0126472386314 2400.106930927327 2392.514294247872 2170.027602762158 0.8695093463297182 0.8826641822598214 1.1017882504363938 0.9517103558878538 0.9979357002766138 0.9865616472236634 1.0340940568600603 1.1060259914999737 1.102527125093947 1.0 11.083497678536823 -3.1002278519715762 0.4619989527191759 1.0535773710845169 7.946362610091574e-13 0.5050178533987202 0.057364597799255686 18.175255686823903 0.8703999841776261 0.037277880440858766 14.590155171677058 0.0007939116008679304 3.1002278519715762 -1.0535773710837222 S(ph)PSFGAGEGLLR ddPTM_A459_Selumetinib_30min_R1 2 SPSFGAGEGLLR 12 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 S(0.762)PS(0.238)FGAGEGLLR;S(0.882)PS(0.118)FGAGEGLLR 145.81 0.00067324 44108000.0 2347.1000000000004 2464.3 2867.9 2988.1000000000004 2441.2 2124.97 2378.6 2012.29 1366.77 1934.7200000000003 True False 2401.7828633384142 2175.7786103780118 2478.454932247068 2466.284428583884 2220.393891028866 2103.594731118388 2199.180286978153 1958.9175323608795 2319.308865068808 2183.060157768684 1.1001908741687119 0.996664522796241 1.1353122466310357 1.129737272611253 1.0171015595366557 0.9635990669485179 1.0073841891860396 0.8973264091646006 1.0624117969517544 1.0 11.092136171343851 -6.465428693082106 5.081939588053619 0.9816785585509415 1.0864818087630668 0.46788923393696147 0.052453382339868036 0.18887192791955185 10.248666270461488 0.016496315985715698 0.018385160810885065 3.4242960661242746e-07 6.465428693082106 0.10480325021212522 S(ph)PSFGDPQLS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 1 SPSFGDPQLSPEAR 14 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 2 S(1)PSFGDPQLS(1)PEAR 135.69 0.010942 2283100.0 417.2 691.37 486.97 414.78 519.28 607.57 654.23 720.8 347.39 595.31 True False 426.9199482701152 610.4240789908072 420.8421487347379 342.3464593849011 472.31121568633 601.4583974294225 604.880904376405 701.6820425116273 589.4954576382668 671.7238373104506 0.6355587289852357 0.9087426187448034 0.626510666079336 0.5096535813819554 0.7031330279679237 0.8953953455599142 0.9004904557181098 1.0445989907416833 0.8775860329723861 1.0 9.391724416184342 -6.819666603846001 3.1688357835089254 0.9533752687330742 0.6747001265365522 0.6337819655047858 0.10246011528033357 0.17835840234940006 3.6368143567519957 0.04037343336137867 0.03632611215216797 1.514723614663569e-07 6.819666603846001 -0.278675142196522 S(ph)PSFGDPQLS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 2 SPSFGDPQLSPEAR 14 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 2 S(1)PSFGDPQLS(1)PEAR;S(1)PSFGDPQLS(1)PEAR 181.86 0.0013708 9528000.0 44656.0 36977.0 43581.0 48910.0 51318.0 39753.5 45533.0 46952.0 44330.0 37083.0 True False 42174.1982921317 39813.01700020527 40777.04590740505 42248.37362554391 44870.97405125909 45229.183778656945 47650.37472192781 47088.62254667798 53197.23868368976 36012.31743679499 1.1711048134058963 1.1055388776376545 1.1323082992082532 1.173164534598302 1.2459896292431576 1.2559364961179857 1.3231687964974401 1.3075699065832946 1.477195650545287 1.0 15.136202821260229 -6.361690492913137 1.4428574875155669 1.2991711539088624 1.1314397616447667 0.2185109807369171 0.11188960873815983 0.5167902469218107 2.1703850990347036 0.04158074040693008 0.0528420789950494 4.348199953793564e-07 6.361690492913137 -0.16773139226409572 S(ph)PSFGGASEASAR ddPTM_A459_Selumetinib_30min_R1 1 SPSFGGASEASAR 13 0 H7C2F7;Q8WVT3 H7C2F7 TRAPPC12 Trafficking protein particle complex subunit 12 1 S(1)PSFGGASEASAR 145.61 0.00062246 5057800.0 262.3 222.85 428.56 366.33 308.84 312.8 351.85 463.47 265.38 339.54 True False 268.4110796530467 196.75861839984574 370.36390591157425 302.35734236576235 280.9054765301307 309.653515999676 325.30967122393974 451.1772700372698 450.33047741167906 383.1232663996752 0.7005867385068689 0.5135647862079633 0.9666964614078271 0.7891907615194071 0.7331986886880668 0.8082346940439913 0.8490992319024965 1.1776295245055688 1.1754192890543305 1.0 8.581664830520069 -7.639855659517602 3.5831555317849526 1.1333101521468687 0.7555821504370126 0.664519652198072 0.11575325246714756 0.14286477129824857 3.5176443866913703 0.06297883366499736 0.03353485585134187 2.2916291634736605e-08 7.639855659517602 -0.3777280017098561 S(ph)PSFGGASEASAR ddPTM_A459_Selumetinib_30min_R2 4 SPSFGGASEASAR 13 0 H7C2F7;Q8WVT3 H7C2F7 TRAPPC12 Trafficking protein particle complex subunit 12 1 S(1)PSFGGASEASAR;S(0.993)PS(0.007)FGGASEASAR;S(0.787)PS(0.212)FGGAS(0.001)EASAR;S(1)PSFGGASEASAR 134.04 0.0012616 21288900.0 28549.1 29070.100000000002 28704.7 26535.8 31007.4 19594.0 32265.9 45594.2 27225.1 52064.2 True False 26962.45531310232 31299.683194895948 26857.870853314285 22921.578263191757 27111.973202326895 22292.89564337742 33766.328283667914 45726.87157347385 32670.880732851827 50560.971266962835 0.5332661663230335 0.6190482977400308 0.5311976843068192 0.4533452916116942 0.5362233462481405 0.44091114321500136 0.6678338536137112 0.9043906876716262 0.6461679812349528 1.0 15.625736557237166 -7.534419897498151 4.414483561885357 0.8288138065060212 0.5229337299956386 0.7079969385981911 0.09495401998010343 0.1115395176229369 5.405830139658452 0.0435774572937492 0.02556421628762012 2.9213265282421636e-08 7.534419897498151 -0.3058800765103826 S(ph)PSGAGEGASCSDGPR ddPTM_A459_Selumetinib_30min_R2 1 SPSGAGEGASCSDGPR 16 0 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 S(0.996)PS(0.004)GAGEGASCSDGPR 147.51 0.00031541 1837800.0 979.95 852.08 1906.0 2326.2 2652.4 813.67 978.44 1181.7 865.5 1255.6 True False 925.4883020506644 917.431796130971 1783.370035095891 2009.3675470811743 2319.181799243143 925.7456567391504 1023.9393987420782 1185.1385513590337 1038.624184090536 1219.3475655594145 0.7590028702161448 0.7523956434112122 1.4625608689985887 1.6479038494322273 1.901985836318248 0.7592139295529204 0.8397436692074859 0.9719448210119759 0.8517868189731728 1.0 10.251893698263885 S(ph)PSGGAAGPLLTPSQSLDGSR ddPTM_A459_Selumetinib_30min_R2 4 SPSGGAAGPLLTPSQSLDGSR 21 0 Q96CX2 Q96CX2 KCTD12 BTB/POZ domain-containing protein KCTD12 1 S(0.993)PS(0.007)GGAAGPLLTPSQSLDGSR;S(0.585)PS(0.415)GGAAGPLLTPSQSLDGSR;S(0.816)PS(0.184)GGAAGPLLTPSQSLDGSR;S(0.992)PS(0.008)GGAAGPLLTPSQSLDGSR 213.01 4.2492000000000005e-18 18000700.0 14200.300000000001 16830.0 17025.34 19281.600000000002 19814.7 13781.800000000001 18333.0 14896.400000000001 16685.5 20041.9 True False 13411.104174304868 18120.80688302065 15929.948160188607 16655.412817384753 17325.400240334468 15680.117851275854 19185.520826150336 14939.746057768229 20023.066231822806 19463.238271890124 0.6890479367800743 0.9310273362471091 0.8184633994434273 0.8557369839858259 0.8901602086101346 0.8056273900690997 0.9857311798858834 0.7675878930868882 1.0287633513042491 1.0 14.248464143631871 -1.5228793876837294 0.05400097491371978 1.2405210352581773 0.16580529345430783 0.3477678753692365 0.08445015791980529 507.545959500294 2.0686334720895876 9.14214375654897 44.31282335803878 0.029999955624378606 1.5228793876837294 -1.0747157418038693 S(ph)PSGHPHVR ddPTM_A459_Selumetinib_30min_R2 7 SPSGHPHVR 9 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7 Q8WX93 PALLD Palladin 1 S(1)PSGHPHVR;S(0.99)PS(0.01)GHPHVR;S(0.999)PS(0.001)GHPHVR;S(0.994)PS(0.006)GHPHVR;S(0.998)PS(0.002)GHPHVR;S(0.996)PS(0.004)GHPHVR;S(0.999)PS(0.001)GHPHVR 106.62 0.0086411 107664500.0 9362.96 8908.73 13771.11 8001.539999999999 11667.970000000001 17683.089999999997 32138.350000000002 84344.0 32526.78 51822.74 True False 8842.604166098563 9592.000944918162 12885.091775450892 6911.716448573601 10202.135295624726 20118.775136391287 33632.84695593238 84589.42707609906 39033.04487416797 50326.482844551225 0.17570479132053907 0.19059549570642553 0.2560300471473528 0.137337561814573 0.20271902026488023 0.39976517330913613 0.6682932137303881 1.6808134066785363 0.7755965183327732 1.0 15.619030155607412 -7.4143801589590534 2.763142842073823 1.1724845155180157 0.21334570644099524 0.7621155898364049 0.22955956258793195 0.11796926436919467 1.744375750783225 0.10514915789371869 0.06349557340952659 3.851410774609968e-08 7.4143801589590534 -0.9591388090770204 down S(ph)PSGLRPR ddPTM_A459_Selumetinib_30min_R1 2 SPSGLRPR 8 1 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 S(0.999)PS(0.001)GLRPR;S(1)PSGLRPR 75.738 0.03162 9553000.0 1329.52 1830.89 1434.73 1430.53 1545.62 1229.63 1597.8000000000002 1742.97 1098.25 1315.47 True False 1360.4952292044184 1616.5285476423312 1239.9015464077681 1180.7147898738672 1405.8189439013747 1217.261038614711 1477.27665960384 1696.740773635531 1863.6500369936564 1484.3233882628854 0.916576023771084 1.0890676253064815 0.8353311388961094 0.7954565691076703 0.9471109564248091 0.8200780559277453 0.9952525650981676 1.1431072144064505 1.2555552595413186 1.0 10.535589729596518 -7.629163597175291 3.477136313307319 1.1505867969333445 0.9034880130881148 0.5310703394572879 0.09701901886795701 0.18253581074519537 4.289667520537571 0.05190322456736951 0.027659298523653217 2.3487478892689814e-08 7.629163597175291 -0.24709878384522976 S(ph)PSGLRPR ddPTM_A459_Selumetinib_30min_R2 1 SPSGLRPR 8 1 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 S(0.977)PS(0.023)GLRPR 64.84100000000001 0.047556 3689200.0 2044.9 1045.3 2559.4 1022.3 2433.2 602.12 939.65 1226.6 577.85 2727.1 True False 1931.2526443832883 1125.4711488307473 2394.7309904640206 883.0609764341352 2127.519662916008 685.0565644988473 983.3455868811517 1230.1692029254384 693.4361464780086 2648.3615371432647 0.7292254540392141 0.42496884698181003 0.9042311470235176 0.33343671702265987 0.8033343005014797 0.25867184479570876 0.3713033787455874 0.4645019895026861 0.2618359075045337 1.0 11.370884367622992 -10.82437647680907 3.3242925770249516 1.0023477114548958 0.5063228520175549 0.3169602370742708 0.2176751265386771 98874736.58979921 142340174.76622227 2318266.808234859 0.05193820711635246 1.4983853671927036e-11 10.82437647680907 -0.49602485943734087 S(ph)PSGPPAMDLEGPR ddPTM_A459_Selumetinib_30min_R1 1 SPSGPPAMDLEGPR 14 0 O96018 O96018 APBA3 Amyloid beta A4 precursor protein-binding family A member 3 1 S(0.999)PS(0.001)GPPAMDLEGPR 173.33 0.00010617 6814700.0 299.15 198.56 324.39 213.63 236.19 312.51 270.93 278.89 137.42 254.96 True False 306.1196129554287 175.31250289196038 280.339619746723 176.3235308317577 214.8266562027314 309.3664331363772 250.49353197300573 271.492931237608 233.19170324030793 287.686599520708 1.0640732431243947 0.6093871010468849 0.9744618630613131 0.6129014390156388 0.7467384875091061 1.075359205648745 0.8707167187847237 0.9437107313650375 0.8105754791109849 1.0 8.168354211493998 -6.731147785005415 24.9999022224252 0.9322197858041772 0.7899686777476714 0.1768959525198993 0.14791806919545655 345.3636851731551 285030.6792499437 0.04614522076903141 0.04613984718023153 1.8571723749150903e-07 6.731147785005415 -0.14225110805650576 S(ph)PSGPPAMDLEGPR ddPTM_A459_Selumetinib_30min_R2 3 SPSGPPAMDLEGPR 14 0 O96018 O96018 APBA3 Amyloid beta A4 precursor protein-binding family A member 3 1 S(0.993)PS(0.007)GPPAMDLEGPR;S(0.999)PS(0.001)GPPAMDLEGPR;S(0.967)PS(0.033)GPPAMDLEGPR 206.67 7.3982000000000014e-06 16336900.0 15596.599999999999 14512.08 13606.14 17829.9 14981.7 14586.599999999999 13186.5 14502.68 12622.7 14327.9 True False 14729.803410136632 15625.109872308167 12730.735765645135 15401.436861706927 13099.56490790266 16595.771746028826 13799.698378554043 14544.880397752082 15147.592707706075 13914.216298645062 1.0586153825689046 1.12296011050437 0.914944506568065 1.1068849679450998 0.9414518666910668 1.1927205521194095 0.9917697182771141 1.0453251613724326 1.0886414572397525 1.0 13.76427203245909 S(ph)PSHSGNAGDLK ddPTM_A459_Selumetinib_30min_R1 2 SPSHSGNAGDLK 12 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.976)PS(0.024)HSGNAGDLK;S(0.998)PS(0.002)HSGNAGDLK 156.2 0.00043309 290930000.0 6607.7 7252.3 7533.299999999999 8166.6 7757.2 6697.8 6979.299999999999 6876.099999999999 3819.2 6148.6 True False 6761.646553653978 6403.197344497196 6510.319237454877 6740.45661606812 7055.562629644894 6630.426213115825 6452.845781933333 6693.72349127941 6480.903456668488 6937.832702435768 0.9746050162437712 0.9229391395167443 0.9383793926263461 0.9715507572994154 1.0169692658008016 0.9556912796107037 0.9300953278489745 0.96481477406184 0.9341394834143436 1.0 12.760269336834913 -5.760355459380198 24.999947557880336 0.9661397223400183 0.9430709752904225 0.11753475249851353 0.027595791895491665 64.48145779504249 1487155.4693528933 0.007945913614521783 0.012817427630731635 1.7363790633187162e-06 5.760355459380198 -0.023068747049595828 S(ph)PSHSGNAGDLK ddPTM_A459_Selumetinib_30min_R2 4 SPSHSGNAGDLK 12 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.999)PS(0.001)HSGNAGDLK;S(0.997)PS(0.003)HSGNAGDLK;S(1)PSHSGNAGDLK;S(0.985)PS(0.015)HSGNAGDLK 148.85 0.00059175 439892000.0 144965.0 126404.0 131669.0 136374.0 144444.0 103730.0 136835.0 135398.0 100747.0 147575.0 True False 136908.42564087416 136098.7803470794 123197.5598903676 117799.62594172836 126297.65337425594 118017.86593281306 143198.0986334085 135791.98576365446 120899.21510637693 143314.1263041023 0.9553030756393427 0.9496536305031615 0.8596330527037593 0.8219680011987514 0.8812645105637484 0.8234908098479253 0.9991903961341004 0.947512916315825 0.8435959400808645 1.0 17.128821295791425 -7.262404807089476 24.999982423565505 0.9432008867339882 0.8812026574331776 0.23325445672377465 0.058122085949996155 154.15957197984406 3991918.684924659 0.024575898560546365 0.01767673606484896 5.4650632535403146e-08 7.262404807089476 -0.06199822930081056 S(ph)PSKPLPEVTDEYK ddPTM_A459_Selumetinib_30min_R2 2 SPSKPLPEVTDEYK 14 1 P05455;E9PFL9;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 1 S(0.5)PS(0.5)KPLPEVTDEYK;S(0.948)PS(0.052)KPLPEVTDEYK 104.41 0.0034126 19819400.0 119441.0 85566.0 101114.0 111928.0 95103.0 92240.0 119934.0 125305.0 101859.0 93865.0 True False 112802.94738020649 92128.63706194569 94608.43532459906 96683.21331343027 83155.3109083926 104945.22272864812 125511.16864471248 125669.61680464039 122233.64617825278 91154.87355944118 1.2374867407023369 1.0106825171763254 1.037886748456799 1.0606477694292902 0.9122420739706018 1.1512848258213466 1.3769002549585887 1.3786384852225426 1.340944717547608 1.0 16.476032170998472 -7.0399446949825855 5.514439402443995 1.3023706610371395 1.0471959945340596 0.398346500459386 0.1267115766637768 0.1720051151193389 13.55154249154708 0.04649963175639942 0.03685687162381334 9.121269863233283e-08 7.0399446949825855 -0.25517466650307985 S(ph)PSKPLPEVTDEYKNDVK ddPTM_A459_Selumetinib_30min_R1 1 SPSKPLPEVTDEYKNDVK 18 2 P05455;E9PFL9;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 1 S(0.5)PS(0.5)KPLPEVTDEYKNDVK 56.851000000000006 0.024412 33719000.0 2541.2 2707.5 3518.8 3816.8 2476.9 2331.7 3056.6 3479.8 1637.9 2761.2 True False 2600.40501568556 2390.504641317399 3040.9662873848406 3150.267530209487 2252.864832332213 2308.2452150142094 2826.0382011172233 3387.504400016596 2779.3966725171044 3115.62691636562 0.8346329921680524 0.7672628031169803 0.9760367235920945 1.0111183446457945 0.7230855596022969 0.7408605962702294 0.9070528265989555 1.0872625288422275 0.8920826360555619 1.0 11.605306771548753 -7.528800897499818 24.30478065689199 0.9932351461584353 0.8451836601311238 0.3231187938762252 0.09785183204360803 145.76084156184905 598192.0942292362 0.04881790684751925 0.028299229606143426 2.9593688795950064e-08 7.528800897499818 -0.14805148602731155 S(ph)PSKPLPEVTDEYKNDVK ddPTM_A459_Selumetinib_30min_R2 1 SPSKPLPEVTDEYKNDVK 18 2 P05455;E9PFL9;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 1 S(0.5)PS(0.5)KPLPEVTDEYKNDVK 65.477 0.013031 17384000.0 122910.0 117640.0 113900.0 104300.0 110520.0 89923.0 97448.0 110920.0 79805.0 110630.0 True False 116079.15424771368 126662.60972778086 106571.79800494324 90094.16007246428 96635.48953866385 102309.07701028006 101979.52508954877 111242.75883620542 95768.22993800722 107435.82444874028 1.080451095743183 1.1789606528147791 0.9919577436275989 0.8385858305154995 0.8994717547382951 0.9522808386795943 0.949213408216597 1.0354344968915048 0.8913994045226515 1.0 16.713115614283552 -5.416941624207774 4.894429794088085 0.9373965440404408 1.1269216053905677 0.6369962784711259 0.05693818985906045 0.1341231540540291 4.932933989724317 0.015418182954002204 0.03305139382171883 3.828762042508407e-06 5.416941624207774 0.18952506135012692 S(ph)PSKPTLAYPESNSR ddPTM_A459_Selumetinib_30min_R2 1 SPSKPTLAYPESNSR 15 1 F5GXS6;F5H6R3;F5H0C6;F5H1B0;F5GYW0;Q86XR8-3;Q86XR8-2;Q86XR8-4;Q86XR8-5;Q86XR8 F5GXS6 CEP57 Centrosomal protein of 57 kDa 1 S(0.99)PS(0.008)KPT(0.002)LAYPESNSR 110.04 0.020862 0.0 4480.0 4331.7 3982.8 2485.6 4303.5 3589.9 3737.9 4472.0 3572.8 4617.4 True False 4231.01953486094 4663.927461389217 3726.550984144761 2147.056992100838 3762.855856221862 4084.376139132417 3911.719756508335 4485.012779620547 4287.4598323728105 4484.083664554034 0.9435639143637027 1.0401071456932927 0.8310618763879345 0.47881733542863647 0.8391582623595177 0.9108608234540222 0.8723565502200273 1.0002072028838038 0.9561507217772265 1.0 12.130597481028254 -7.463994349110503 1.5536845270618498 0.9862438480927544 0.8269788615436977 0.181203745328662 0.13717782754605032 0.7975886062751806 3.721989279271953 0.10034149706650136 0.050580591655129 3.435624181860765e-08 7.463994349110503 -0.15926498654905674 S(ph)PSLDNPTPFPNLGPSENPLKR ddPTM_A459_Selumetinib_30min_R2 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653-3;Q14653-2;Q14653;Q14653-4 M0R0R8 IRF3 Interferon regulatory factor 3 1 S(0.664)PS(0.23)LDNPT(0.106)PFPNLGPSENPLKR 116.44 1.7162999999999998e-05 14987000.0 73416.0 72848.0 77412.0 80297.0 76122.0 51607.0 67370.0 66693.0 52302.0 73580.0 True False 69335.83262753356 78435.20735676122 72431.3961998129 69360.41007994903 66558.87382068572 58715.39580829738 70502.83849112241 66887.06558837954 62763.86143998061 71455.55421620092 0.9703351039409227 1.0976782451290235 1.0136566288557416 0.9706790583428591 0.9314723613968557 0.8217051347841201 0.9866670165037709 0.9360653111163529 0.8783622508906429 1.0 16.12475853542947 -5.918996364816241 2.313192943752645 0.9209439577787504 1.0369378332518913 0.4000779631497906 0.05560510366506042 0.2733924649012922 2.967285569525377 0.01682059838178611 0.027609551906919532 1.2050460269503635e-06 5.918996364816241 0.11599387547314088 S(ph)PSLESLSRPPSLGFGDTR ddPTM_A459_Selumetinib_30min_R2 1 SPSLESLSRPPSLGFGDTR 19 1 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 S(0.862)PS(0.137)LESLSRPPSLGFGDTR 81.226 0.0032196 3238100.0 6134.9 5411.8 5648.1 6062.7 6784.9 5007.9 5740.2 6243.1 5768.6 6327.0 True False 5793.9468179505275 5826.8676583203305 5284.707395186312 5236.949801259154 5932.520204224401 5697.692767810032 6007.130673990513 6261.266387399155 6922.481188150973 6144.32307047979 0.9429756136664372 0.9483335416256571 0.8600959511026569 0.8523233139253236 0.9655286898449417 0.9273100881013925 0.9776716824757452 1.0190327421878604 1.1266466799914574 1.0 12.585038360083981 -7.565769636166089 1.4881384795616268 1.063965299126343 0.9105522124119433 0.6418272273833417 0.04487719988387303 0.2618378585006545 1.110340334541825 0.032736063666412525 0.014961543379333203 2.717880538263718e-08 7.565769636166089 -0.1534130867143998 S(ph)PSLGSDLTFATR ddPTM_A459_Selumetinib_30min_R1 1 SPSLGSDLTFATR 13 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 1 S(0.997)PS(0.003)LGSDLTFATR 140.33 0.00088762 77518000.0 242.95 403.58 269.84 250.41 220.9 340.04 439.35 354.95 80.36 325.32 True False 248.61026230159257 356.3286659807482 233.19721012502157 206.68059427786574 200.91963400306264 336.61950633161734 406.2094757772857 345.5355729599086 136.36505073781942 367.0779908851452 0.6772682331133824 0.9707165093759045 0.6352797386808912 0.5630427304548855 0.5473486261559284 0.9170244871394155 1.1066026453881959 0.9413137849172304 0.3714879511272213 1.0 8.519942806275012 -6.781524133118526 24.99583039123627 0.878575236275878 0.6861114447974833 0.16433366489999346 0.2115078398091293 480.8578835935932 598432.0909586146 0.07773876111493173 0.06864406191962609 1.6537728844419226e-07 6.781524133118526 -0.19246379147839465 S(ph)PSLGSDLTFATR ddPTM_A459_Selumetinib_30min_R2 4 SPSLGSDLTFATR 13 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 1 S(0.999)PS(0.001)LGSDLTFATR;S(0.982)PS(0.018)LGSDLTFATR;S(0.998)PS(0.002)LGSDLTFATR;S(0.998)PS(0.002)LGSDLTFATR 203.74 5.1593e-05 127801000.0 323656.3 246860.2 312875.6 322646.0 294881.3 241242.7 298108.3 302669.7 230682.7 321904.7 True False 305668.7785448238 265793.5835593501 292745.52452919644 278701.05820460536 257835.67482173044 274471.6921418088 311970.9266403901 303550.41871733405 276825.685813174 312610.4749021458 0.9777944217656338 0.8502388912033404 0.9364546233482178 0.8915282134798751 0.8247825825492217 0.8779990249134316 0.9979541688039857 0.9710180658928728 0.8855291426169477 1.0 18.254006595180627 -7.2487708044849954 24.87675646344638 0.9612101837500587 0.8899726148220675 0.3256289065229623 0.049523862384788356 858.8855853006837 1686559.9692996119 0.018931820557687894 0.014562592903152696 5.6393518969272514e-08 7.2487708044849954 -0.07123756892799127 S(ph)PSLLQSGAK ddPTM_A459_Selumetinib_30min_R2 2 SPSLLQSGAK 10 0 Q9BQG0;Q9BQG0-2;I3L1L3;I3L2H8 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 S(0.995)PS(0.005)LLQSGAK;S(0.994)PS(0.006)LLQSGAK 99.732 0.01818 54146000.0 204399.0 180681.0 208721.0 213014.0 223237.0 181035.0 251664.0 244409.0 179957.0 185312.0 True False 193039.32185402708 194538.65171901658 195292.11809824177 184001.12573035405 195191.97229589874 205970.92797789292 263366.8746627556 245120.18972591162 215953.4284186949 179961.56106160124 1.0726697452238108 1.0810011347502457 1.0851879531729158 1.0224468194481269 1.084631468767289 1.1445273466336991 1.463461825453962 1.3620697013291991 1.1999975280541915 1.0 17.457329261058888 -7.0292541158133 10.184799007163425 1.2891489186585094 1.0726949445637897 0.3611287167663789 0.11408375432481753 0.5389524761698575 184.54065122829223 0.04162739899379903 0.03283900758213237 9.348585066038436e-08 7.0292541158133 -0.21645397409471978 S(ph)PSLSPSPPSPLEK ddPTM_A459_Selumetinib_30min_R1 1 SPSLSPSPPSPLEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.744)PS(0.018)LS(0.232)PS(0.004)PPS(0.002)PLEK 120.9 0.0019996 3823800.0 1700.9 2131.9 1671.7 1655.0 1803.6 1363.9 2118.6 1901.4 691.54 1564.3 True False 1740.5276606247335 1882.2961569065785 1444.6923219908042 1365.9853181976262 1640.4646984514427 1350.180404322117 1958.7922963053531 1850.968695382364 1173.4928719167704 1765.0931425723377 0.9860826143645859 1.0664004700417318 0.8184793692447294 0.7738885191106253 0.9293927095885324 0.7649343662139254 1.1097387718875449 1.0486521366713129 0.6648333980871934 1.0 10.78552860004618 -5.252749088507014 24.677518310557147 0.891298725132025 1.0262415477820876 0.1469437810453984 0.1324050864105683 1071.1116477600342 3041577.514869926 0.03420683923797404 0.08745905716067157 5.587929413585584e-06 5.252749088507014 0.13494282265006263 S(ph)PSLSPSPPSPLEK ddPTM_A459_Selumetinib_30min_R2 2 SPSLSPSPPSPLEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.438)PS(0.072)LS(0.178)PS(0.231)PPS(0.081)PLEK;S(0.894)PS(0.091)LS(0.015)PSPPSPLEK 106.55 0.0054871 11911600.0 137681.0 152840.0 141941.0 155427.0 160105.0 118819.0 128176.0 118488.0 119187.0 145804.0 True False 130029.24120071171 164562.33654194121 132808.6705936758 134257.57447346972 139991.17854313963 135185.23871850892 134136.4379759257 118832.78046325577 143027.73036302597 141594.25967571262 0.918322829601371 1.1622105085250731 0.9379523640142046 0.9481851508737303 0.9886783465922668 0.9547367176333136 0.9473296324521401 0.8392485736032907 1.0101237909686196 1.0 17.111403253238727 S(ph)PSMAVPSPGWVASPK ddPTM_A459_Selumetinib_30min_R2 2 SPSMAVPSPGWVASPK 16 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 S(0.968)PS(0.032)MAVPSPGWVASPK;S(0.93)PS(0.069)MAVPS(0.001)PGWVASPK 121.95 0.001484 15810800.0 64584.0 49133.0 63355.0 60804.0 69606.0 60724.0 64301.0 66559.0 56553.0 56328.0 True False 60994.679830236324 52901.34311250471 59278.808275708376 52522.39030724948 60861.47199446476 69088.17980241154 67291.12391001434 66752.6756705644 67865.1802228448 54701.66428228 1.1150424878388001 0.967088365712513 1.0836746752312452 0.9601607372714531 1.1126073181320035 1.262999594416214 1.2301476525973372 1.2203042914032176 1.240641964248773 1.0 15.73929710681346 -6.535802447096229 5.568184534887916 1.206085920216536 1.0307478578422815 0.4528618794711634 0.081674657457598 0.13058135928262543 13.356400276439565 0.024925484909034727 0.025809690058265083 2.912041453156966e-07 6.535802447096229 -0.17533806237425442 S(ph)PSMISNDSETLEECMVCSDMKR ddPTM_A459_Selumetinib_30min_R1 1 SPSMISNDSETLEECMVCSDMKR 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 S(0.85)PS(0.145)MIS(0.005)NDSETLEECMVCSDMKR 119.5 3.0554e-05 0.0 494.16 345.01 619.7 506.31 426.78 470.96 419.26 439.03 154.83 355.52 True False 505.67296653202277 304.61606880920226 535.5481437684398 417.8924631157947 388.1778243541288 466.22256999746645 387.63488065183765 427.38549822957776 262.7352016642185 401.15445505805616 1.260544311938005 0.7593485874788987 1.335017315689374 1.0417245972136 0.9676517846422786 1.1622021496183894 0.9662983316382167 1.0653888866016092 0.6549477348474038 1.0 8.648014009105236 -8.227176431259926 23.168863109164022 0.8274739258978674 1.0635591062512093 0.24188631237965197 0.17129966024444385 297.60511523355655 201243.45960207446 0.10657222173099978 0.040272899314474836 5.926844987800472e-09 8.227176431259926 0.23608518035334192 S(ph)PSMPENLNRPR ddPTM_A459_Selumetinib_30min_R1 1 SPSMPENLNRPR 12 1 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;H0Y999 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 S(0.683)PS(0.317)MPENLNRPR 108.23 0.0044802 27873000.0 1796.3 2128.9 2223.6 2153.7 2409.9 1830.9 1840.8 1790.1 978.59 1458.8 True False 1838.1502950086472 1879.6473983012406 1921.6473333605027 1777.5967249560288 2191.9249705024017 1812.4828083241914 1701.946973963418 1742.6207329357164 1660.5957566142702 1646.0511899153137 1.1167029957939623 1.1419130886190392 1.1674286590439316 1.0799158226953336 1.3316262482791754 1.1011096249184331 1.0339575004656933 1.0586673996604996 1.008836035469653 1.0 10.684793486939618 -6.999974112113868 24.99999999952995 1.0355797921468373 1.1667376914741907 0.5243387835696102 0.06353211924683033 0.796327744406601 767532.9532580083 0.022473386448658945 0.019625114378844757 1.0000596108373513e-07 6.999974112113868 0.13115789932735344 S(ph)PSMPENLNRPR ddPTM_A459_Selumetinib_30min_R2 1 SPSMPENLNRPR 12 1 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;H0Y999 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 S(0.832)PS(0.168)MPENLNRPR 65.565 0.042858 5903200.0 34038.0 23131.0 29934.0 37442.0 31239.0 27787.0 34535.0 36702.0 24382.0 29603.0 True False 32146.304224909956 24905.073322112345 28008.07902967493 32342.33500894737 27314.477539796615 31614.407024728396 36140.945929804264 36808.7967436568 29259.081290000526 28748.28447216897 1.1181990443996959 0.8663151133843409 0.9742521873536271 1.125017913338717 0.9501254784868846 1.0996971682026488 1.2571513950612283 1.2803823747914822 1.0177679060580487 1.0 14.811188246655538 -6.966807946833652 6.077534401286182 1.164627313219653 1.0048231937054108 0.23431962134378126 0.11004523897263711 0.21644332165516988 23.035701154422387 0.03899573671830103 0.033833542449110056 1.0794239582227459e-07 6.966807946833652 -0.15980411951424212 S(ph)PSPAHLPDDPK ddPTM_A459_Selumetinib_30min_R1 1 SPSPAHLPDDPK 12 0 Q92615;H0Y4V9;A0A087X183;H0Y641 Q92615 LARP4B La-related protein 4B 1 S(0.995)PS(0.005)PAHLPDDPK 182.23 0.00010418 231390000.0 7474.4 8229.0 7821.8 8471.6 7404.8 6592.4 7467.3 7444.4 3758.2 6191.2 True False 7648.538977349346 7265.544854441692 6759.642522071939 6992.194091627199 6735.037147423622 6526.086441420287 6904.035549042281 7246.9503291808505 6377.390911932216 6985.900827394911 1.0948536439790166 1.0400297733901644 0.9676121503993144 1.0009008522147365 0.964090002682612 0.9341796573791197 0.9882813569251371 1.03736805148482 0.9128945671435172 1.0 12.770230446885115 -4.978191510800688 2.2011612796334563 0.9759668951054201 1.1042519179026746 0.5688435264847271 0.03350383729577518 0.3067222926549959 2.3402909288029825 0.008888654920499228 0.06633373714908558 1.0514980925496483e-05 4.978191510800688 0.1282850227972545 S(ph)PSPAHLPDDPK ddPTM_A459_Selumetinib_30min_R2 1 SPSPAHLPDDPK 12 0 Q92615;H0Y4V9;A0A087X183;H0Y641 Q92615 LARP4B La-related protein 4B 1 S(0.5)PS(0.5)PAHLPDDPK 82.57799999999997 0.023859 252330000.0 318500.0 285640.0 353580.0 351340.0 401620.0 282500.0 293630.0 309840.0 254670.0 325080.0 True False 300799.04505651974 307547.66952263925 330831.04774879635 303486.88590469485 351164.9050716453 321411.810720329 307284.37681680673 310741.58310322696 305611.11607433425 315694.095740725 0.9528180891401962 0.9741951898119239 1.0479481631500107 0.9613321566645461 1.1123581651018648 1.0181115676749934 0.9733611776799745 0.9843123051576946 0.9680609178238425 1.0 18.268167753379664 -10.670130319047672 16.519515333505478 0.9999999999999959 1.0014444682898866 0.0 0.0465348505053483 0.0 0.0 0.0460598775498222 0.01117116119064309 2.137320645972954e-11 10.670130319047672 0.0014444682898907546 S(ph)PSPALHPPQK ddPTM_A459_Selumetinib_30min_R1 1 SPSPALHPPQK 11 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 S(0.956)PS(0.044)PALHPPQK 71.806 0.041257 10816000.0 9310.5 11955.0 10229.0 10254.0 10687.0 9079.6 10849.0 10409.0 5165.2 8749.2 True False 9527.41653492068 10555.30304227128 8839.957983875058 8463.331391419017 9720.36273694309 8988.267467617194 10030.651195419994 10132.919506802898 8764.967148718086 9872.245044424917 0.9650709126492996 1.069189732910054 0.8954354297422129 0.857285384766503 0.9846152210770337 0.9104583027639771 1.0160456056633778 1.0264047803923981 0.8878393019293888 1.0 13.269162489521083 -7.267301883505129 24.77888093539003 0.9847728171312607 0.947849578399034 0.06834101509446189 0.06407661542104305 1404.6781429097352 5937081.559428565 0.02748455890661756 0.019108463971066015 5.403785684895202e-08 7.267301883505129 -0.03692323873222669 S(ph)PSPALHPPQK ddPTM_A459_Selumetinib_30min_R2 1 SPSPALHPPQK 11 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 S(0.919)PS(0.081)PALHPPQK 73.46600000000002 0.03813 6723000.0 43719.0 31537.0 53897.0 64354.0 67798.0 61464.0 55917.0 63157.0 63656.0 49084.0 True False 41289.2730010235 33955.78649256222 50429.32569861664 55588.87418315792 59280.609118189874 69930.10808536036 58517.251297433475 63340.77641379577 76388.97869724702 47666.817384452326 0.866205785630886 0.7123569047770685 1.0579545366304521 1.1661964702784953 1.2436452100434476 1.4670605658721771 1.2276307609435715 1.3288232755907863 1.6025609194995911 1.0 15.540697682386275 -5.668367260084311 1.3590249926844309 1.3351309431939202 0.7676933724956627 0.6260564458807102 0.15619776138590263 0.2792636994293339 1.004967037394377 0.049728922755722056 0.13824414923366216 2.146014934216462e-06 5.668367260084311 -0.5674375706982575 S(ph)PSPAPPPR ddPTM_A459_Selumetinib_30min_R2 1 SPSPAPPPR 9 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 S(0.998)PS(0.002)PAPPPR 112.3 0.0097763 2099700.0 7582.2 6520.0 8310.7 6878.1 7230.0 6614.7 7907.4 6974.6 5536.7 8041.4 True False 7160.811677951473 7020.063034895705 7775.998610005995 5941.290914615697 6321.7027629799195 7525.814882731889 8275.10976821585 6994.894931292816 6644.194708323598 7809.223887933645 0.9169684184642138 0.898945034184856 0.9957453802830538 0.7608042745189867 0.8095174185936511 0.9637084287415985 1.0596584099736295 0.8957221654383501 0.8508137048791518 1.0 12.930963459320346 -6.796933352942993 24.981642965656736 0.9540681026459118 0.8778575092490633 0.19606013270392308 0.07852480235730575 337.1274691046452 237277.33391040997 0.029690902579082586 0.026185868696882168 1.5961240704729973e-07 6.796933352942993 -0.07621059339684855 S(ph)PSPAVPLR ddPTM_A459_Selumetinib_30min_R1 2 SPSPAVPLR 9 0 Q6P4R8-3;Q6P4R8;Q6P4R8-2;E9PQ59 Q6P4R8-3 NFRKB Nuclear factor related to kappa-B-binding protein 1 S(0.989)PS(0.011)PAVPLR;S(0.597)PS(0.403)PAVPLR 109.66 0.0113 33404000.0 7315.799999999999 8150.1 7997.200000000001 8901.4 8680.9 6563.0 7959.0 7286.700000000001 4293.1 6167.799999999999 True False 7486.2439059312255 7195.882503121308 6911.22416547518 7346.937589972422 7895.714127737375 6496.982178727216 7358.64622217234 7093.433045462651 7285.077144381936 6959.497209459605 1.0756874642834322 1.033965857956003 0.9930637167410872 1.0556707429936452 1.1345236430305956 0.9335418900515224 1.0573531392713538 1.0192450448605677 1.0467821058222124 1.0 12.764767366652615 -6.760699819896561 24.999999972863 1.0154603107367037 1.0534130166556674 0.20465854243923642 0.04560752403837499 43.05306564405915 1455386.6243495157 0.015783647980972444 0.01490645735251102 1.7350028003931437e-07 6.760699819896561 0.037952705918963714 S(ph)PSPAVPLR ddPTM_A459_Selumetinib_30min_R2 2 SPSPAVPLR 9 0 Q6P4R8-3;Q6P4R8;Q6P4R8-2;E9PQ59 Q6P4R8-3 NFRKB Nuclear factor related to kappa-B-binding protein 1 S(0.942)PS(0.058)PAVPLR;S(0.7)PS(0.3)PAVPLR 117.53 0.0075039 37288000.0 84273.0 67204.0 94536.0 86828.0 94628.0 64486.0 76662.0 82440.0 66159.0 71875.0 True False 79589.4440315482 72358.33070508139 88453.65668301414 75001.87661334533 82739.98465494654 73368.3611543756 80226.9349028711 82679.88675132334 79392.64863691032 69799.78199632275 1.1402534758022769 1.0366555401117648 1.2672483230345064 1.0745288089480944 1.1853903019253773 1.05112593558302 1.1493866113664608 1.1845292977516628 1.1374340487351802 1.0 16.090934910062956 S(ph)PSPFTHTHLAQGYR ddPTM_A459_Selumetinib_30min_R2 1 SPSPFTHTHLAQGYR 15 0 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 S(0.828)PS(0.172)PFTHTHLAQGYR 142.4 0.00025241 14150000.0 47299.0 40387.0 49717.0 60742.0 65614.0 40752.0 44600.0 49665.0 35133.0 58069.0 True False 44670.310932898996 43484.5530353271 46518.262347776756 52468.83481420546 57370.98272339757 46365.2180901764 46673.98837322342 49809.51692751663 42160.58169803907 56392.397088618745 0.7921335718838324 0.7711066611868369 0.8249030853339127 0.9304239139143609 1.0173531483905713 0.8221891688220848 0.8276645573316705 0.8832665305793379 0.747628827194296 1.0 15.783213048877059 S(ph)PSPGLFR ddPTM_A459_Selumetinib_30min_R1 3 SPSPGLFR 8 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 S(0.938)PS(0.062)PGLFR;S(0.93)PS(0.07)PGLFR;S(0.983)PS(0.017)PGLFR 106.68 0.013623 46179200.0 14546.400000000001 15798.1 15722.099999999999 16685.0 14857.2 13203.2 14430.3 12828.9 7419.0 10533.9 True False 14885.302817632792 13948.451107662573 13587.125175313522 13771.27796624013 13513.368883251707 13070.387795546434 13341.81085309882 12488.635897859907 12589.50113767897 11886.02867387506 1.252336101994268 1.1735165285542868 1.1431173142950086 1.1586105287217388 1.136912021165948 1.0996429635303286 1.1224784340646512 1.0506987859880694 1.0591848196824656 1.0 13.536979145974723 -1.5228787452952697 0.12326494680107766 0.9508707875601188 1.849991879331501 0.9094851023073962 0.020407002319552055 25.423785916210974 0.21515592168252498 0.13246826201747017 3.938188302384781 0.029999999998968525 1.5228787452952697 0.8991210917713823 S(ph)PSPGLFR ddPTM_A459_Selumetinib_30min_R2 1 SPSPGLFR 8 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 S(0.938)PS(0.062)PGLFR 104.01 0.014949 21469000.0 118740.0 102770.0 127950.0 117490.0 160360.0 92108.0 98384.0 86969.0 70901.0 116260.0 True False 112140.90615388124 110652.12854236664 119717.83630142668 101487.65931844544 140214.14316341068 104795.04092682502 102959.05094419754 87222.06539150709 85083.18113946043 112903.27172024336 0.99324762201532 0.9800613113900304 1.0603575474594638 0.8988903312732689 1.2418961915544786 0.9281842707489535 0.9119226518015702 0.7725379793034671 0.7535935836322196 1.0 16.78472776768838 -7.268341494039104 2.5627180300048766 0.8293350708257051 1.0271263116882317 0.3625885910697064 0.10624668448318603 0.286903028604876 3.7260765896065977 0.04806467044993535 0.031904123265946854 5.390865617621188e-08 7.268341494039104 0.19779124086252653 S(ph)PSPGNSPSGR ddPTM_A459_Selumetinib_30min_R2 2 SPSPGNSPSGR 11 0 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 S(0.938)PS(0.062)PGNSPSGR;S(0.997)PS(0.003)PGNSPSGR 119.74 0.004931399999999999 728770.0 1480.17 1220.4499999999998 2797.2799999999997 1582.59 1791.57 1770.0500000000002 2011.92 1799.35 1737.98 3230.5 True False 1397.9080769899813 1314.0545906347327 2617.3060502481817 1367.038511879974 1566.4969597609859 2013.8583205859047 2105.4782665438493 1804.5858106015708 2085.6245632185687 3137.227071152986 0.44558715237537 0.41885861648892203 0.8342737044170271 0.43574739120734524 0.4993253354738109 0.6419230342309192 0.6711271510767784 0.5752168299180058 0.6647987270019524 1.0 11.61527423927251 -14.522878744355136 0.16110722481329445 2.6035127731638372 0.46436210494562086 0.5806334256549612 0.11526145115208462 98.94930538185422 0.9093615801745389 50.50934420813272 0.48696246716260505 3.000000006391065e-15 14.522878744355136 -2.139150668218216 S(ph)PSPGPNHTSNSSNASNATVVPQNSSAR ddPTM_A459_Selumetinib_30min_R1 2 SPSPGPNHTSNSSNASNATVVPQNSSAR 28 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 S(0.584)PS(0.046)PGPNHT(0.357)S(0.012)NS(0.001)SNASNATVVPQNSSAR;S(0.926)PS(0.066)PGPNHT(0.005)S(0.003)NSSNASNATVVPQNSSAR 117.65 2.7355e-12 4114300.0 251.4 272.21 518.27 512.79 453.915 442.12 461.56 676.55 142.27 131.43 True False 257.2571308607546 240.33952665300436 447.89178065333124 423.24085276046003 412.85846839520207 437.6726742128413 426.7441575959123 658.6056962558843 241.4217990103232 148.30032073661212 1.7347038063232147 1.6206271534628567 3.0201673093398544 2.8539442845316185 2.7839351010471303 2.9512591209439605 2.8775673274087428 4.441026782575857 1.6279249957867516 1.0 7.212377907760251 -5.257763215193888 24.675915497721384 2.841971705665571 1.6776653208183412 0.16522228079778611 0.8647964665947936 359.9159494012993 2415870.858070794 0.20749462401399585 0.5057634312905662 5.523785234476218e-06 5.257763215193888 -1.1643063848472297 S(ph)PSPGPNHTSNSSNASNATVVPQNSSAR ddPTM_A459_Selumetinib_30min_R2 1 SPSPGPNHTSNSSNASNATVVPQNSSAR 28 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 S(0.492)PS(0.492)PGPNHT(0.011)S(0.005)NSSNASNATVVPQNSSAR 63.713 0.00088344 3261600.0 2514.7 2250.9 2088.6 2184.8 2137.0 1160.3 2564.0 3166.7 3005.8 2668.6 True False 2374.9430411416956 2423.536792215758 1954.2217498957386 1887.2264710097807 1868.530954977605 1320.1207928453011 2683.231080469616 3175.914572724594 3607.0439890691323 2591.550584144515 0.9164177831109853 0.9351686233883721 0.7540743220880783 0.7282228958045842 0.7210088687481349 0.5093941831280442 1.0353766956686146 1.2254881661022954 1.391847803835107 1.0 11.339599838439577 -7.50438109226644 4.939865881986483 1.2187600090203514 0.7639348865055995 0.6718913208229265 0.14128666255225747 0.11269124900224414 7.647004542945603 0.06771792303809572 0.04175568554638761 3.130537480292323e-08 7.50438109226644 -0.45482512251475193 S(ph)PSPISNQPSPR ddPTM_A459_Selumetinib_30min_R2 1 SPSPISNQPSPR 12 0 F6SS63;Q8N5C8-2;Q8N5C8 F6SS63 TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 1 S(0.483)PS(0.418)PIS(0.096)NQPS(0.003)PR 96.756 0.016828 15654000.0 8017.0 7185.9 8649.4 7592.0 10929.0 6353.1 6854.5 8226.9 6516.4 7725.4 True False 7571.447234593778 7737.035423689724 8092.907020754668 6557.9565030695085 9556.001313500348 7228.181857300246 7173.247831934078 8250.838916963388 7819.862083428731 7502.347629000242 1.0092103977328954 1.031281914181409 1.0787166125802576 0.874120585631063 1.2737348075636659 0.9634560026730551 0.9561337579461084 1.0997676094173325 1.0423220130724336 1.0 12.873126397970088 -4.807912423555741 4.687690105257967 1.0378963591335564 1.008213186065869 0.005892422630247474 0.10081213341776732 1.5933427741562785 69.78329542806728 0.024235591005579923 0.13630353866626083 1.5562794271589486e-05 4.807912423555741 -0.02968317306768742 S(ph)PSPLGTSVR ddPTM_A459_Selumetinib_30min_R1 1 SPSPLGTSVR 10 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 S(0.539)PS(0.461)PLGTSVR 139.43 0.0015279999999999998 39376000.0 1664.4 2450.9 2062.9 2165.8 2083.0 1964.4 2055.7 2125.7 1185.1 1584.4 True False 1703.1772816413702 2163.9474886075013 1782.7695106985882 1787.5836871011604 1894.593017783519 1944.6399195324925 1900.6368939464344 2069.3195307532833 2011.0281437206306 1787.7731733629173 0.9526808585216564 1.2104150128491835 0.9972011758880368 0.9998940098975753 1.0597502222385777 1.087744210790734 1.063130895051531 1.1574843842525946 1.1248788010045794 1.0 10.803947988508126 -6.9474702196680225 1.9558309575435129 1.1000219966771736 1.0480313689991045 0.06464519855889128 0.07460621224240464 0.9040185599641694 7.014184606302047 0.03220286469362548 0.025874257207164963 1.1285733231205482e-07 6.9474702196680225 -0.05199062767806906 S(ph)PSPLQAPEK ddPTM_A459_Selumetinib_30min_R2 1 SPSPLQAPEK 10 0 H7BXG9;E7ESK9;Q9Y2G0-2;Q9Y2G0-3;Q9Y2G0 H7BXG9 EFR3B Protein EFR3 homolog B 1 S(0.564)PS(0.436)PLQAPEK 84.365 0.037973 3079400.0 38160.0 14585.0 25111.0 30377.0 18605.0 16815.0 56835.0 33633.0 22758.0 19791.0 True False 36039.21996658336 15703.622601833411 23495.385598789566 26239.600196752148 16267.67356918968 19131.11361862771 59477.94011641597 33730.86646175712 27310.23591164926 19219.582406806625 1.875130229355038 0.8170636733643061 1.2224711807717874 1.3652533984015895 0.8464113956725966 0.9953969453494691 3.094653091700464 1.7550259806795445 1.4209588602704148 1.0 14.230289369866414 S(ph)PSPLSGHVAQAFPTK ddPTM_A459_Selumetinib_30min_R2 2 SPSPLSGHVAQAFPTK 16 0 Q6P0Q8;A0A669KBJ4 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 S(0.794)PS(0.206)PLSGHVAQAFPTK;S(0.487)PS(0.487)PLS(0.026)GHVAQAFPTK 145.33 0.00037864 21456500.0 179251.0 143027.0 202841.0 238081.0 240378.0 173762.0 169087.0 192515.0 151589.0 163157.0 True False 169288.94701860653 153996.7109957097 189790.43089658252 205653.95708736737 210179.56663341433 197696.13824561343 176949.88053953424 193075.1867774262 181911.03575054897 158446.23347720425 1.0684315007271046 0.971917776877071 1.1978222942351469 1.297941595544175 1.3265040261348529 1.2477174995394011 1.1167818676168917 1.218553338506491 1.148093152853145 1.0 17.273633839374092 -5.275093656944774 20.86652573830045 1.2095622410197973 1.0201747237529664 0.3562328892884584 0.09171761736652427 74.56726972202127 113956.17238896326 0.02401450768287375 0.05069680450418825 5.307699697067044e-06 5.275093656944774 -0.1893875172668309 S(ph)PSPLTGK ddPTM_A459_Selumetinib_30min_R2 4 SPSPLTGK 8 0 Q9P2F8;Q9P2F8-2 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 S(0.583)PS(0.311)PLT(0.106)GK;S(0.728)PS(0.272)PLTGK;S(0.664)PS(0.3)PLT(0.036)GK;S(0.648)PS(0.35)PLT(0.001)GK 109.44 0.0097175 34668000.0 424685.0 389580.0 420552.0 449970.0 474222.0 327776.0 379062.0 397961.0 306776.0 377605.0 True False 401082.70784875366 419459.53330286377 393494.14218239585 388683.309758454 414645.99276153033 372924.168745722 396689.1340971033 399119.00062401016 368139.77203761804 366702.5625143867 1.0937548543392523 1.1438685631939298 1.0730607920607536 1.0599416243326767 1.1307420104141286 1.01696635602619 1.0817735534137156 1.088399813427406 1.0039192786474596 1.0 18.484250822062286 -5.901581642244512 0.07871283291352593 0.8958035981220951 1.2826836732657632 0.4615946718516222 0.034705931556641534 55.99334508887627 1.0885715133400249 1.7774866862249195 3.661885792426013 1.2543489128791984e-06 5.901581642244512 0.38688007514366807 S(ph)PSPLVSLQAVK ddPTM_A459_Selumetinib_30min_R1 2 SPSPLVSLQAVK 12 0 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 S(0.531)PS(0.469)PLVSLQAVK;S(0.939)PS(0.061)PLVSLQAVK 159.66 0.00046544 128629000.0 6397.9 6100.4 6971.6 7587.8 6412.1 6040.4 6037.9 6426.799999999999 3522.4 4972.8 True False 6546.958621853714 5386.1623320009785 6024.895012257633 6262.7331706464975 5832.126687148204 5979.639060244383 5582.456341858823 6256.340386811498 5977.255534082815 5611.1073191738915 1.1667854933877126 0.9599107672732891 1.0737443911774374 1.1161314183469482 1.039389616951196 1.0656789685364187 0.9948938817803102 1.1149921095668158 1.065254181408676 1.0 12.454069791011216 S(ph)PSPLVSLQAVK ddPTM_A459_Selumetinib_30min_R2 1 SPSPLVSLQAVK 12 0 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 S(0.779)PS(0.221)PLVSLQAVK 91.307 0.023218 52440000.0 52974.0 36134.0 45396.0 52580.0 68898.0 42954.0 58069.0 56484.0 39414.0 38328.0 True False 50029.91715172396 38905.36161087747 42475.27078342764 45418.51329444078 60242.41728406509 48870.52360241062 60769.323561540594 56648.35908857043 47297.90131917319 37221.371051896516 1.3441180627647733 1.0452425719792273 1.141152772803715 1.2202267678725554 1.6184900120973809 1.3129694640821286 1.632646026843341 1.5219310167158409 1.2707189440503763 1.0 15.183843577701522 -6.0692921655395065 8.392339785580912 1.4267724777328623 1.1663651133978579 0.21150579117975576 0.18829542540006763 0.42460964233211634 48.03418908321886 0.05270146747477689 0.06831721269994288 8.525263958477506e-07 6.0692921655395065 -0.26040736433500444 S(ph)PSPPDGS(ph)PAATPEIR ddPTM_A459_Selumetinib_30min_R1 1 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 2 S(0.857)PS(0.143)PPDGS(1)PAATPEIR 116.04 0.03553 3766600.0 1071.4 1351.2 1230.3 1627.0 1168.0 1305.8 1327.2 1155.0 560.78 884.69 True False 1096.3615354185065 1193.0008758441625 1063.2320175541574 1342.8749925725308 1062.354606227149 1292.6648375715374 1227.0882354651494 1124.3656480312563 951.6027022493079 998.2485791103508 1.0982850948764635 1.1950939884205765 1.065097451480192 1.345231058349529 1.064218500740497 1.2949328099455684 1.229241154100858 1.126338340529673 0.9532722832396975 1.0 9.963255303127504 -8.128648224309517 3.8288307964639685 0.9778620902674245 1.1858774248217263 0.4618261353670323 0.08827370325451925 0.20204863318586055 4.984907064293066 0.06442046117778817 0.021921081731026425 7.4362122234910015e-09 8.128648224309517 0.20801533455430177 S(ph)PSPPDGSPAATPEIR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 S(0.955)PS(0.045)PPDGSPAATPEIR 125.33 0.001214 49970000.0 28325.0 30832.0 31896.0 41730.0 33487.0 30012.0 34881.0 29105.0 23661.0 32370.0 True False 26750.809893958944 33196.71525949452 29843.846085739006 36046.302011734755 29280.063682421656 34145.880578189404 36503.03561539026 29189.690731407856 28393.861143577327 31435.393992639598 0.8509774014673549 1.0560298772545154 0.9493708299863127 1.1466788684173888 0.9314361922512376 1.086224037344162 1.1612081472221158 0.928561313347701 0.9032449585402229 1.0 14.940102224665669 -1.5708486368142829 19.522063462493254 1.008352892359545 0.0050343628141247265 0.0 0.10123342675025705 0.0 0.0 0.02281999313980002 0.0 0.02686280522782844 1.5708486368142829 -1.0033185295454203 S(ph)PSPPLPLSCSNSTR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPLPLSCSNSTR 15 0 Q96HJ3-2;Q96HJ3 Q96HJ3-2 CCDC34 Coiled-coil domain-containing protein 34 1 S(0.959)PS(0.041)PPLPLSCSNSTR 89.9 0.016119 33372000.0 20509.0 23215.0 24484.0 26194.0 24392.0 17392.0 17811.0 19326.0 18509.0 23315.0 True False 19369.191884031912 24995.51585200978 22908.72609616361 22626.33201282963 21327.658892753265 19787.590131143203 18639.246791826943 19382.235460408458 22211.317184669835 22641.83537035503 0.8554603267450662 1.1039527248191383 1.0117875040359148 0.99931527823289 0.9419580411170015 0.8739393166444054 0.8232215492667755 0.8560364097420137 0.9809857205194207 1.0 14.46670328879639 -6.455353819861285 3.05095851132408 0.8930720964282094 1.0019926989494248 0.20481482563722864 0.07609364489822874 0.3311105396636787 6.049283856656951 0.025100917738749666 0.027880982082522605 3.5046623265406484e-07 6.455353819861285 0.10892060252121538 S(ph)PSPPLPTHIPPEPPRT(ph)PPFPAK ddPTM_A459_Selumetinib_30min_R1 1 SPSPPLPTHIPPEPPRTPPFPAK 23 1 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 2 S(0.48)PS(0.48)PPLPT(0.042)HIPPEPPRT(0.999)PPFPAK 127.59 1.3428e-05 20625000.0 8942.4 10248.0 11944.0 12176.0 11544.0 9486.7 11114.0 10143.0 5130.5 8353.3 True False 9150.740521118587 9048.159395834053 10322.070403695734 10049.690171827375 10499.847238258735 9391.272411234428 10275.662032067261 9873.97469089267 8706.083783105803 9425.527423032347 0.9708465224723354 0.9599631924812874 1.0951186008405835 1.0662204586312927 1.1139798089814228 0.9963657193639676 1.0901949112107523 1.047577949512352 0.9236707286885081 1.0 13.202357634003997 -10.593419863241817 14.084956867132945 0.9999999999999958 1.03415395051674 0.014791851906888032 0.06130620032150826 0.0 0.0 0.060789388736394646 0.014743592282909775 2.5502346180257703e-11 10.593419863241817 0.0341539505167443 S(ph)PSPPLPTHIPPEPPRT(ph)PPFPAK ddPTM_A459_Selumetinib_30min_R2 1 SPSPPLPTHIPPEPPRTPPFPAK 23 1 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 2 S(0.454)PS(0.455)PPLPT(0.092)HIPPEPPRT(0.999)PPFPAK 98.391 8.8055e-05 9442400.0 136570.0 128820.0 141650.0 154940.0 151990.0 111980.0 115560.0 118550.0 101420.0 139960.0 True False 128979.98613302651 138700.079778415 132536.39321685873 133836.9047135919 132895.65739216006 127404.22854676946 120933.76897779593 118894.96087299095 121706.83391156801 135918.99114024843 0.9489474947613327 1.0204613690466324 0.9751131324989063 0.9846814164143691 0.977756355291302 0.937354136298047 0.8897488714657251 0.8747487004984374 0.8954365603404489 1.0 17.052387523696346 -6.9029275014981755 2.8091457321914604 0.904892226414265 0.9841126233173795 0.42284654485222084 0.03603445491986743 0.21475441226276845 3.4265589917916452 0.01332729831387121 0.011406065465297788 1.250467758342042e-07 6.9029275014981755 0.07922039690311444 S(ph)PSPSFR ddPTM_A459_Selumetinib_30min_R1 2 SPSPSFR 7 0 P49585;C9JEJ2 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 1 S(0.989)PS(0.011)PSFR;S(0.995)PS(0.005)PSFR 123.98 0.0068524 121454000.0 7184.3 8535.4 8710.1 10131.8 8558.2 7003.6 7934.5 7659.8 4439.7 6808.6 True False 7351.680211785684 7536.0714000001935 7527.316261154571 8362.47132744092 7784.112321072931 6933.150142760012 7335.9942768974015 7456.637221463042 7533.846637141573 7682.55013138018 0.9569322797851949 0.9809335794918307 0.9797939658614736 1.0885020187871643 1.0132198538188395 0.9024542663823091 0.9548905183101593 0.9705940207283031 0.9806439929846716 1.0 12.90736956061083 -6.65744774169101 20.46130881748477 0.9592370822827062 1.0059715331807866 0.21451198678750782 0.04009247345675552 4.971857034679296 960.37116851288 0.014056232753381226 0.014056217705174488 2.2006564969491933e-07 6.65744774169101 0.04673445089808037 S(ph)PSPSFR ddPTM_A459_Selumetinib_30min_R2 2 SPSPSFR 7 0 P49585;C9JEJ2 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 1 S(0.758)PS(0.242)PSFR;S(0.998)PS(0.002)PSFR 94.114 0.02482 126174000.0 490170.0 444280.0 588610.0 535230.0 444270.0 418920.0 418100.0 431810.0 371300.0 414970.0 True False 462928.3137059786 478354.847414642 550739.4734301121 462330.7506767508 388456.83077580755 476622.4274228678 437542.47844943235 433066.4956100064 445570.3749888112 402988.7378784565 1.1487375953558292 1.1870179050981726 1.3666373813062191 1.1472547672441213 0.9639396694330653 1.1827189760489525 1.085743687907719 1.0746367203458214 1.1056645834186998 1.0 18.620379995487987 -5.996353124474424 24.995926159980154 1.076927482410322 1.2340074124424105 0.48631700199871375 0.07606206791139669 94.7881521051543 649669.962442961 0.021135397344574855 0.031185519444245677 1.0084325969454849e-06 5.996353124474424 0.15707993003208842 S(ph)PSPSPTPEAK ddPTM_A459_Selumetinib_30min_R1 2 SPSPSPTPEAK 11 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 S(0.999)PS(0.001)PSPTPEAK;S(0.589)PS(0.401)PS(0.01)PTPEAK 142.89 0.00088397 16025400.0 5920.799999999999 6096.6 6841.2 6885.299999999999 6348.8 5926.1 6084.1 5648.5 3411.4 5911.1 True False 6058.743120128708 5382.807237767555 5912.202616021707 5682.911608088293 5774.552160971681 5866.488814468288 5625.171438662991 5498.683431086195 5788.896641202059 6669.8472639898655 0.9083780902809462 0.8070360571566657 0.8864074966066106 0.8520302464450749 0.8657697743917115 0.8795536962504577 0.8433733511459819 0.8244091976098585 0.8679204203754395 1.0 12.703438009489139 -8.573909069774325 21.296803566291715 1.0000000001909326 0.8571054368718093 0.6943923268284551 0.02802999352422453 3305.0836609219914 1379328.751238482 0.025403220040847805 0.006559083212423773 2.6674170953985686e-09 8.573909069774325 -0.1428945633191233 S(ph)PSPSVR ddPTM_A459_Selumetinib_30min_R2 1 SPSPSVR 7 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 S(0.971)PS(0.028)PSVR 90.37 0.029739 85362000.0 31395.0 21997.0 29235.0 29783.0 21618.0 19308.0 26065.0 23545.0 26637.0 25582.0 True False 29650.191584142678 23684.09916849705 27354.051928661283 25726.504021459314 18902.153572627925 21967.50173942692 27277.074146817657 23613.51205191541 31965.144299964886 24843.38118998164 1.193484548556516 0.9533363831348335 1.1010599450807486 1.0355476102356713 0.7608526966631427 0.8842396118079753 1.0979614223291567 0.9504950985269998 1.2866664185330448 1.0 14.600573917602752 -10.1493275076679 10.880800318393526 1.0000003846203518 1.0168948227171553 0.0 0.14476453535615982 0.0 0.0 0.1410242504188712 0.03420340472062128 7.09042866953684e-11 10.1493275076679 0.016894438096803466 S(ph)PSPVLR ddPTM_A459_Selumetinib_30min_R1 1 SPSPVLR 7 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-2 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 S(0.625)PS(0.375)PVLR 95.815 0.023547 67741000.0 1405.5 1659.0 1858.9 1612.8 1338.8 1346.3 1658.2 1569.5 718.04 1201.2 True False 1438.245415373074 1464.7635087518247 1606.471590206798 1331.1547560055183 1217.7057763843375 1332.7574443425951 1533.1206389755212 1527.8717615455041 1218.4614364333477 1355.3857206788286 1.0611336635985407 1.0806986427584728 1.185250490467183 0.9821224583499563 0.8984201012346981 0.98330491756627 1.131132352646947 1.127259744761283 0.8989776252202922 1.0 10.404487762160656 -5.782398540090546 24.993400236535443 1.0084903518126809 1.1061947473548066 0.26867834619322606 0.07974194087411207 361.517290430823 431101.24169408454 0.02440050634344451 0.03623392325094712 1.6504465337274861e-06 5.782398540090546 0.09770439554212573 S(ph)PSPVLR ddPTM_A459_Selumetinib_30min_R2 4 SPSPVLR 7 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-2 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 S(0.972)PS(0.028)PVLR;S(0.95)PS(0.05)PVLR;S(0.95)PS(0.05)PVLR;S(0.645)PS(0.355)PVLR 106.04 0.017291 236760000.0 101602.0 78941.0 103479.0 125162.0 117197.0 79620.0 94055.0 91476.0 78892.0 105913.0 True False 95955.3675850314 84995.52086467795 96821.2737994167 108114.71968350677 102473.66510552652 90586.93228160206 98428.74386644682 91742.18001533306 94672.60442665566 102855.01649497819 0.932918693272645 0.8263624251018207 0.9413373999521347 1.05113706037649 0.9962923403986788 0.8807244932581862 0.956965904246902 0.891956300642004 0.9204471269641765 1.0 16.650252633841077 -5.492992106230629 22.455309968440915 0.9542685580982588 0.8806927675291044 0.23885510195371207 0.05418755853769066 292.72328798269336 219934.85838538193 0.0149604654428698 0.031029110920223285 3.2137189509083337e-06 5.492992106230629 -0.07357579056915442 S(ph)PSPYYSR ddPTM_A459_Selumetinib_30min_R1 2 SPSPYYSR 8 0 Q13595;Q13595-4;Q13595-3;P62995;H7C2L4;P62995-3;H7BXF3 Q13595;P62995 TRA2A;TRA2B Transformer-2 protein homolog alpha;Transformer-2 protein homolog beta 1 S(1)PSPYYSR;S(0.999)PS(0.001)PYYSR 125.71 0.0050199 56347000.0 2419.2 2385.7 2713.7 2381.8999999999996 2323.7 1827.55 2162.2 2410.1 1029.48 1901.8 True False 2475.562653056237 2106.3811349181606 2345.194445287098 1965.9458788005606 2113.521745282557 1809.1665062826353 1999.1035132027932 2346.176318891887 1746.9523697557283 2145.914555100731 1.1536166000514556 0.9815773558697379 1.0928647833217258 0.9161342767015612 0.9849048930018308 0.8430748102166219 0.9315857933164323 1.0933223381681922 0.8140829119236414 1.0 11.067376917426335 -1.5228787458802708 0.5957907047272974 0.9418660070328715 13.125953697713358 0.342057031051202 0.08462181788646225 194.086564777145 1.526073751244988 0.03731435463642278 3074.5406435938985 0.029999999958558076 1.5228787458802708 12.184087690680487 S(ph)PSPYYSR ddPTM_A459_Selumetinib_30min_R2 1 SPSPYYSR 8 0 Q13595;Q13595-4;Q13595-3;P62995;H7C2L4;P62995-3;H7BXF3 Q13595;P62995 TRA2A;TRA2B Transformer-2 protein homolog alpha;Transformer-2 protein homolog beta 1 S(1)PSPYYSR 114.86 0.010127 49262000.0 33418.0 46351.0 49342.0 57614.0 52769.0 28697.0 33391.0 30612.0 53023.0 28861.0 True False 31560.761342853308 49905.97265804459 46167.38943950759 49766.873810306446 46139.68645915451 32649.751264570878 34943.747663011265 30701.0758519106 63629.08158640379 28027.707940116514 1.1260557377822493 1.780594145075037 1.647205313333077 1.7756312402226195 1.6462168992818005 1.1649097862133335 1.2467572352927123 1.0953830372967335 2.270220658869163 1.0 14.774566147514802 -6.7364192694179845 24.815228228052266 1.3546219841061977 1.6183634836974112 0.0930278287666747 0.37066624561310907 494.949973253292 490895.5857755409 0.11921531873146347 0.11916746498142394 1.8347661983372692e-07 6.7364192694179845 0.2637414995912135 S(ph)PSQESIGAR ddPTM_A459_Selumetinib_30min_R2 2 SPSQESIGAR 10 0 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 S(0.999)PS(0.001)QESIGAR;S(0.999)PS(0.001)QESIGAR 142.76 0.0011637000000000002 37334000.0 17027.5 12923.7 12053.0 12642.400000000001 15331.2 19134.6 13540.3 18507.8 23758.5 15562.5 True False 16081.179716483171 13914.90623375485 11277.523102314157 10920.483310643564 13405.157593333022 21770.21746339539 14169.95077959544 18561.65463386876 28510.86386795495 15113.17018876904 1.0640507263283174 0.9207139243423164 0.7462049961360692 0.7225805819852963 0.8869851543982954 1.4404798722886984 0.937589572710924 1.2281774374288705 1.8864912861989775 1.0 13.883518696299301 -6.716344718958949 9.0444509879222 1.290031648674955 0.8551959491839777 0.4085689378616977 0.2586268763587544 0.33176499266048165 62.23262111504935 0.08643327242302987 0.08607323870899986 1.921565890616374e-07 6.716344718958949 -0.43483569949097733 S(ph)PSQGSYSR ddPTM_A459_Selumetinib_30min_R2 1 SPSQGSYSR 9 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(1)PSQGSYSR 127.52 0.0045443 43334000.0 41317.0 39388.0 34309.0 36898.0 45021.0 25818.0 35282.0 39879.0 38396.0 41115.0 True False 39020.76654505566 42408.93294761838 32101.596292814782 31872.428747399725 39365.05948715338 29374.195147530787 36922.68290995667 39995.04128767615 46076.272873876645 39927.9031204009 0.9772806357346188 1.0621377441168407 0.8039890348364596 0.7982495011393352 0.9859035013296269 0.7356808860949734 0.9247338333450139 1.00168148492729 1.1539867930187968 1.0 15.285109688003427 -7.877168231753197 3.173490450547418 1.0771485431538572 0.8934239388759988 0.3484607373265426 0.09951274338010725 0.281836112866822 5.516988689297152 0.06625763130253037 0.028011411300039712 1.3268803672677377e-08 7.877168231753197 -0.18372460427785842 S(ph)PSQLR ddPTM_A459_Selumetinib_30min_R2 2 SPSQLR 6 0 O00499-6;O00499-11;O00499-2;O00499 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 S(1)PSQLR;S(0.999)PS(0.001)QLR 90.37 0.046914 37809000.0 21204.4 14394.1 23669.5 21122.4 23379.3 23327.0 45069.0 76260.0 34609.1 42280.0 True False 20025.944335938675 15498.081185673644 22146.63013940306 18245.49268182763 20442.183320406148 26540.082508577383 47164.797802529305 76481.90397447742 41531.88705905001 41059.26654336738 0.4877326367919161 0.37745635736830196 0.5393820202806466 0.4443696689651404 0.49787015310696847 0.6463847200130906 1.1487004462856922 1.8627196833556718 1.0115106906545308 1.0 15.325420235839179 -7.256280207998128 2.959340278169626 1.3534728412200356 0.47541662801597245 0.7240054209755542 0.23025787304685055 0.12436135379621105 2.206973087340527 0.09749326079804282 0.06671414517648143 5.542679823342632e-08 7.256280207998128 -0.8780562132040632 down S(ph)PSQYHDFAEK ddPTM_A459_Selumetinib_30min_R2 1 SPSQYHDFAEK 11 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 S(0.989)PS(0.011)QYHDFAEK 93.348 0.024349000000000003 0.0 11023.0 9010.1 11264.0 13757.0 16884.0 8620.9 10020.0 9120.3 9623.1 13693.0 True False 10410.385788565205 9701.145697962238 10539.286503315905 11883.27286785132 14762.880975124894 9808.350722261526 10485.949854253337 9146.83856305305 11547.988891879419 13297.64751131338 0.7828742474718368 0.7295384909028978 0.7925677451105005 0.8936372285204027 1.11018741943377 0.7376004450348659 0.7885567612866933 0.6878538895899518 0.8684234472341528 1.0 13.698883420467343 -5.573779866093801 5.456742533024975 0.8572591695049024 0.7569943567357083 0.13616103100483667 0.1161875356727272 0.43448256089962894 28.382920596920354 0.03387110749494733 0.06060613441116985 2.668210776624804e-06 5.573779866093801 -0.10026481276919419 S(ph)PSSDSWTCADTSTER ddPTM_A459_Selumetinib_30min_R1 2 SPSSDSWTCADTSTER 16 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 S(0.999)PS(0.001)SDSWTCADTSTER;S(0.998)PS(0.001)SDSWTCADTSTER 254.72 5.7234e-30 37837000.0 1002.72 941.61 580.42 670.12 774.85 587.99 606.77 650.25 433.76 660.94 True False 1026.0814250465241 831.3658634573868 501.6021520188445 553.0961217103287 704.7649543108785 582.0753544522041 561.0008503866703 633.0032576903238 736.059039423053 745.7780871007873 1.3758535451683975 1.1147630613408368 0.6725890190322206 0.7416363275843759 0.9450062511901531 0.7804940430940018 0.7522356316039821 0.8487823236415062 0.9869679092938799 1.0 9.542602597377742 -5.001788739853188 3.7072188668374335 0.8311962352875285 1.351797604783939 0.7232995006957206 0.10558744160813527 0.1088768761820118 3.225736204669523 0.027363410853637967 0.11560477866075049 9.958897445966261e-06 5.001788739853188 0.5206013694964106 S(ph)PSSDSWTCADTSTER ddPTM_A459_Selumetinib_30min_R2 2 SPSSDSWTCADTSTER 16 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 S(0.999)PSSDSWTCADTSTER;S(0.997)PS(0.003)SDSWTCADTSTER 308.03 7.522799999999995e-102 75532000.0 64491.0 54983.0 64889.0 65758.0 70500.0 59367.0 63861.0 56407.0 50622.0 60386.0 True False 60906.84839792783 59200.01930178995 60714.11238580134 56801.646961122846 61643.15972200327 67544.26537003096 66830.66303817085 56571.135031318474 60747.814496858635 58642.49927832973 1.0386127662951579 1.0095070986114374 1.0353261394545838 0.9686089041248087 1.051168699843978 1.1517971812465149 1.1396284923154172 0.9646781042332435 1.0359008440028559 1.0 15.839658970395247 -6.506347301217552 24.745751101460755 1.065738124783968 1.0137984675271674 0.12418943452826492 0.056062948826321964 1310.5660220026268 1961776.1158741005 0.018918361871040724 0.020878232286000737 3.1163964343984667e-07 6.506347301217552 -0.0519396572568005 S(ph)PSSEWLVR ddPTM_A459_Selumetinib_30min_R1 2 SPSSEWLVR 9 0 Q9NWQ4-4;Q9NWQ4 Q9NWQ4-4 GPATCH2L G patch domain-containing protein 2-like 1 S(0.926)PS(0.048)S(0.026)EWLVR;S(0.998)PS(0.002)SEWLVR 149.33 0.0014374 15590800.0 973.84 1374.95 1172.81 1107.71 1310.95 1113.99 1064.52 1399.19 796.12 1005.7 True False 996.5285772372217 1213.9702148030874 1013.5488437841924 914.2692427919598 1192.3748039670204 1102.7842720219917 984.222399350031 1362.0789359903492 1350.9574936957795 1134.7913913475672 0.8781601489361335 1.069773902110321 0.8931587351756352 0.8056716412928221 1.0507436107274948 0.9717947108432264 0.8673157082917811 1.20029015586105 1.1904897270074586 1.0 10.148211395985092 -7.7643581547943334 24.99999946254593 1.1465424876131391 0.9384999170082386 0.4832825658936952 0.092543087441275 62.26869384336496 533325.0340285358 0.04747832623911981 0.02438393364471941 1.720449166515214e-08 7.7643581547943334 -0.2080425706049005 S(ph)PSSEWLVR ddPTM_A459_Selumetinib_30min_R2 3 SPSSEWLVR 9 0 Q9NWQ4-4;Q9NWQ4 Q9NWQ4-4 GPATCH2L G patch domain-containing protein 2-like 1 S(0.942)PS(0.046)S(0.012)EWLVR;S(0.999)PSSEWLVR;S(1)PSSEWLVR 156.16 0.00083589 10352400.0 14781.7 12775.1 13643.5 10052.7 16642.6 15544.0 13551.9 10376.9 7369.599999999999 14495.3 True False 13960.192289833467 13754.909091579146 12765.692063919627 8683.50491812524 14551.807801268264 17685.044905616956 14182.090202580415 10407.095061011727 8843.725923828557 14076.783025687635 0.9917175155970359 0.9771344110709722 0.9068614640592599 0.6168671423207548 1.0337452651443013 1.2563271646188539 1.007480912130322 0.7393091903185992 0.6282490756368357 1.0 13.781030051368079 S(ph)PSSKPSLAVAVDSAPEVAVK ddPTM_A459_Selumetinib_30min_R1 1 SPSSKPSLAVAVDSAPEVAVK 21 1 Q5SRN1;O60508 Q5SRN1 CDC40 Pre-mRNA-processing factor 17 1 S(0.897)PS(0.051)S(0.051)KPSLAVAVDSAPEVAVK 127.16 3.4851e-05 42909000.0 2014.8 3191.2 1797.8 1940.5 1819.6 1938.4 2008.4 2380.6 1215.2 2479.9 True False 2061.740919881658 2817.57282045137 1553.6686346085226 1601.6281026963725 1655.0175012764716 1918.9014559263817 1856.9047710278844 2317.4587547213923 2062.1056453036103 2798.2193212715842 0.7368046186403819 1.006916362499774 0.5552347604770647 0.572374041777594 0.5914538180389621 0.6857580609708543 0.6636022976869655 0.8281905342817368 0.736934960611499 1.0 11.450293328405095 -8.869810269113078 0.8990859762299201 0.9984969908074811 0.690290751729785 0.3368019598767581 0.12607518324646413 1.4887430962239006 2.156033013417525 0.13276323941982454 0.044164946883132467 1.349552334793741e-09 8.869810269113078 -0.30820623907769606 S(ph)PSSKPSLAVAVDSAPEVAVK ddPTM_A459_Selumetinib_30min_R2 2 SPSSKPSLAVAVDSAPEVAVK 21 1 Q5SRN1;O60508 Q5SRN1 CDC40 Pre-mRNA-processing factor 17 1 S(0.882)PS(0.057)S(0.057)KPS(0.005)LAVAVDSAPEVAVK;S(0.935)PS(0.029)S(0.029)KPS(0.006)LAVAVDSAPEVAVK 122.44 3.9912e-05 46085000.0 121541.0 96941.0 126751.0 131333.0 129819.0 113641.0 134944.0 149137.0 121118.0 117098.0 True False 114786.23778717252 104376.0629855561 118595.97865605436 113445.21883793798 113509.97662341491 129294.01621971272 141219.16338646313 149570.96397904062 145344.9843196737 113717.07648285766 1.0094019415322906 0.9178574248810408 1.042903865664645 0.9976093507384473 0.9981788147756862 1.1369797766406984 1.2418465876385 1.3152902677865428 1.2781280421114571 1.0 16.79508938924112 -6.924325076769266 2.580793778640539 1.2342438059364933 0.9898014260708943 0.5865972888900692 0.08497853085068587 0.17574616577960378 2.3745456150838784 0.03264223408017647 0.027402454097097687 1.1903506768548382e-07 6.924325076769266 -0.24444237986559902 S(ph)PSSLLIANLHLQ ddPTM_A459_Selumetinib_30min_R1 1 SPSSLLIANLHLQ 13 0 Q658Y4 Q658Y4 FAM91A1 Protein FAM91A1 1 S(0.941)PS(0.029)S(0.029)LLIANLHLQ 104.81 0.0075167 5533400.0 1335.6 1178.1 1466.8 1976.4 1627.4 1286.4 1198.4 1262.1 762.84 1129.1 True False 1366.7168813747971 1040.1675043161692 1267.6166165556679 1631.2588416228343 1480.2019573408063 1273.4599839577475 1108.0037231626245 1228.6250081214266 1294.483764370808 1274.0309833653562 1.0727501130032262 0.8164381540930535 0.9949652976313459 1.280391813795501 1.161825714340831 0.999551816702212 0.8696834987763247 0.9643603838236418 1.0160535978108052 1.0 10.315184647816753 -6.993828787934698 24.910354312993807 0.9559920022319413 1.0616143115796406 0.14812037409072942 0.11646744298896525 335.66584679910187 1354919.0321735807 0.04618905260673473 0.040626822102412447 1.0143111791766195e-07 6.993828787934698 0.10562230934769934 S(ph)PSSLSANIISSPK ddPTM_A459_Selumetinib_30min_R2 1 SPSSLSANIISSPK 14 0 K7EQL6;Q8NFA0 K7EQL6 USP32 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 32 1 S(0.917)PS(0.062)S(0.021)LS(0.001)ANIISSPK 100.68 0.013035 0.0 8458.1 6343.8 7105.6 7520.0 10367.0 8266.7 7980.6 7136.8 6637.4 7276.6 True False 7988.032662456991 6830.3490614679995 6648.433431992327 6495.763027276431 9064.60477784409 9405.362887368996 8351.7137132589 7157.566906439157 7965.065464451214 7066.505651122683 1.1304077371236378 0.9665808532089457 0.9408374888847736 0.9192326940606669 1.2827563190873499 1.330977905023642 1.1818732094174482 1.0128863203133514 1.1271575878787805 1.0 12.786781271120544 -6.251363815988692 24.84299832760947 1.1666345749923395 0.9841853301885971 0.35164650235329886 0.11021708432228162 736.0447111996992 1814841.0566451678 0.03516389477851795 0.04486055242047392 5.605781732608629e-07 6.251363815988692 -0.18244924480374236 S(ph)PSSQTPNSR ddPTM_A459_Selumetinib_30min_R1 2 SPSSQTPNSR 10 0 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 S(0.979)PS(0.018)S(0.003)QTPNSR;S(0.999)PS(0.001)SQTPNSR 107.34 0.011348 3992900.0 515.6500000000001 569.96 502.45 458.56 576.8199999999999 433.91999999999996 413.28 301.82 333.57 199.66 True False 527.6636417197623 503.22881823278476 434.2200497602915 378.4811042372833 524.6467328458423 429.555158767837 382.10595686636333 293.8147531504709 566.0439270111302 225.28830585309265 2.342170578813107 2.2337103398564024 1.9273971994065253 1.6799855758340405 2.328779254028201 1.9066908827835205 1.696075415097352 1.304172234053122 2.512531331210061 1.0 7.815628618636078 -11.205854544039516 0.15125481257859655 2.405569587406008e-18 2.365969377181109 0.4117905321575227 0.35323373314450307 39.470888710770254 0.9594749024511534 18.13243564956087 2.1826300153196163 6.225087438288757e-12 11.205854544039516 2.365969377181109 S(ph)PSSQTPNSR ddPTM_A459_Selumetinib_30min_R2 4 SPSSQTPNSR 10 0 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 S(1)PSSQTPNSR;S(0.999)PS(0.001)SQTPNSR;S(0.995)PS(0.004)SQTPNSR;S(0.994)PS(0.005)S(0.001)QTPNSR 142.89 0.0011493 46211900.0 22597.86 19940.07 19622.899999999998 27243.8 28391.41 17135.77 23266.600000000002 30004.780000000002 25639.49 35584.89 True False 21341.961407601033 21469.409251569436 18360.383977798087 23533.147441823636 24824.627253374234 19496.066774467574 24348.543001893282 30092.088942241287 30768.10442720678 34557.46176505222 0.617578963197582 0.6212669610266729 0.5313001314340119 0.6809859937578686 0.7183579460248221 0.5641637371117297 0.7045813482319132 0.8707841202814629 0.8903461902494935 1.0 15.076709635434767 -7.850024958138054 1.4577684289194053 0.9677993811617973 0.6210989742889071 0.8574539196679991 0.05497860652143936 0.15441560122406933 0.600129912413627 0.0480232439534002 0.01754074681450222 1.4124563709133666e-08 7.850024958138054 -0.34670040687289017 S(ph)PSSVTGNALWK ddPTM_A459_Selumetinib_30min_R2 1 SPSSVTGNALWK 12 0 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 S(0.997)PS(0.003)SVTGNALWK 134.04 0.0016559 17441000.0 60768.0 49029.0 60899.0 61482.0 62041.0 46619.0 66549.0 57608.0 47595.0 54312.0 True False 57390.75783357802 52789.36664691738 56980.824641817766 53108.04553763425 54246.85492642281 53040.344084853095 69643.66036434175 57775.62974248222 57115.329915412 52743.87144047703 1.0881028689436485 1.0008625685828105 1.0803307206245234 1.0069045765358389 1.028495888619817 1.0056209875437498 1.3204123713773384 1.0953998666496008 1.0828808799116745 1.0 15.686715849557181 S(ph)PSTLLPK ddPTM_A459_Selumetinib_30min_R1 1 SPSTLLPK 8 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 S(0.999)PS(0.001)TLLPK 108.57 0.012819999999999998 248420000.0 5447.9 7745.5 6076.8 5616.3 6717.7 5626.3 6583.9 5842.8 3195.2 5853.4 True False 5574.825470231924 6838.653259214743 5251.6039374730635 4635.518636008058 6110.0852211062665 5569.704530271665 6087.271122271699 5687.829963910847 5422.021031825294 6604.740906944268 0.8440642182300467 1.0354158256267916 0.7951264116888359 0.7018471581730394 0.9251059666370989 0.843288875179894 0.9216517662140996 0.8611738210549069 0.8209286493168181 1.0 12.689286252705248 S(ph)PSTLLPK ddPTM_A459_Selumetinib_30min_R2 1 SPSTLLPK 8 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 S(0.994)PS(0.004)T(0.002)LLPK 96.665 0.020894 176650000.0 536120.0 593950.0 618950.0 594250.0 631460.0 542140.0 590690.0 690980.0 531050.0 620620.0 True False 506324.5966584034 639504.0551497401 579127.4308618053 513312.12486157194 552130.3494759744 616814.8639430766 618158.2554300296 692990.6374021026 637274.8387767512 602701.0880355873 0.8400923885979558 1.0610633825701334 0.9608866523692254 0.8516860763179221 0.9160931686311692 1.0234175384575643 1.0256464899454927 1.1498081738342307 1.0573646728494415 1.0 19.201083143679362 -7.00438830706966 2.3962792192433535 1.07170989896741 0.9317035073736581 0.4549365068514061 0.06826931730875496 0.2779497219987884 3.201731532323757 0.029276726899997413 0.023152284795402905 9.89946428006834e-08 7.00438830706966 -0.14000639159375194 S(ph)PSTTYLHTPTPSEDAAIPSK ddPTM_A459_Selumetinib_30min_R1 4 SPSTTYLHTPTPSEDAAIPSK 21 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(0.205)PS(0.205)T(0.205)T(0.205)Y(0.17)LHT(0.009)PTPSEDAAIPSK;S(0.499)PS(0.146)T(0.146)T(0.146)Y(0.05)LHT(0.011)PT(0.001)PSEDAAIPSK;S(0.768)PS(0.077)T(0.077)T(0.077)Y(0.001)LHTPTPSEDAAIPSK;S(0.557)PS(0.143)T(0.143)T(0.143)Y(0.013)LHT(0.001)PTPSEDAAIPSK 121.56 4.839100000000001e-05 205159000.0 16060.4 17473.9 18336.7 17575.6 18712.7 15329.3 18750.6 16526.800000000003 8193.1 15120.0 True False 16434.576071901614 15428.047664604277 15846.676856283291 14506.351394872638 17020.139588995513 15175.101159890783 17336.227145805326 16088.455577387856 13903.092299651924 17060.79928127198 0.9632946148040213 0.9042980583881548 0.9288355483836296 0.8502738444849172 0.997616776822344 0.8894718770033729 1.0161439015835378 0.9430071424056031 0.814914475602187 1.0 14.058397616599304 -6.268786384789546 24.98751024370036 0.9416042669975414 0.912374271562782 0.06015845824463295 0.06136711075145618 2007.9862031460352 6829238.566094918 0.018574773043000644 0.021495925586434653 5.385346048900238e-07 6.268786384789546 -0.02922999543475946 S(ph)PSTTYLHTPTPSEDAAIPSK ddPTM_A459_Selumetinib_30min_R2 4 SPSTTYLHTPTPSEDAAIPSK 21 0 Q13111 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(0.567)PS(0.124)T(0.124)T(0.124)Y(0.06)LHTPTPSEDAAIPSK;S(0.569)PS(0.144)T(0.144)T(0.144)YLHTPTPSEDAAIPSK;S(0.514)PS(0.138)T(0.138)T(0.138)Y(0.068)LHT(0.003)PTPSEDAAIPSK;S(0.556)PS(0.129)T(0.129)T(0.158)Y(0.018)LHT(0.009)PTPSEDAAIPSK 140.4 1.2950999999999997e-05 265536000.0 295413.0 258948.0 314035.0 308206.0 334419.0 322632.0 286413.0 279902.0 250101.0 280047.0 True False 278995.1280919364 278808.47895094694 293830.32999545586 266227.81111499516 292406.29547620786 367071.6294383049 299731.7720165925 280716.4684797297 300128.18840580806 271961.3154605107 1.0258632836053 1.025176975919689 1.0804122251648711 0.9789179415616259 1.0751760594372686 1.3497200100563729 1.1021117893515782 1.0321926410908622 1.1035694098537598 1.0 18.053041927521335 -6.526184361083795 24.98316755218368 1.1289989811207348 1.0306746349035778 0.17526745249051978 0.09016957243839839 167.6908023050683 1267355.4728256685 0.03066465750387114 0.03080962575409106 2.977252296442937e-07 6.526184361083795 -0.09832434621715702 S(ph)PSVAAMASPQLCR ddPTM_A459_Selumetinib_30min_R1 2 SPSVAAMASPQLCR 14 0 P25325-2 P25325-2 MPST 3-mercaptopyruvate sulfurtransferase 1 S(1)PSVAAMASPQLCR;S(0.725)PS(0.275)VAAMASPQLCR 149.6 0.00043698 14917600.0 1414.98 1321.8400000000001 1601.01 1877.1599999999999 1507.62 1262.72 1500.6799999999998 1426.29 859.01 1292.31 True False 1447.9462809282063 1167.0783582932554 1383.601635718428 1549.3492446573161 1371.2560371919303 1250.018183258027 1387.4824993956001 1388.460155957143 1457.6772303919151 1458.190576665383 0.9929746523526413 0.8003606503631038 0.9488482903808593 1.0625149205122395 0.940381908328981 0.8572392410576342 0.9515097145727828 0.9521801732749494 0.9996479566651418 1.0 10.509963568142107 -14.522878702289418 0.058129876740890804 1.2496061956870215 0.8359690000035844 0.08034391221063364 0.06819301736329109 1172.29052496008 4.971390428458105 41.10208407705953 7.203467902780617 3.0000002969707652e-15 14.522878702289418 -0.41363719568343704 S(ph)PSVAAMASPQLCR ddPTM_A459_Selumetinib_30min_R2 7 SPSVAAMASPQLCR 14 0 P25325-2 P25325-2 MPST 3-mercaptopyruvate sulfurtransferase 1 S(0.984)PS(0.016)VAAMASPQLCR;S(1)PSVAAMASPQLCR;S(1)PSVAAMASPQLCR;S(0.999)PS(0.001)VAAMASPQLCR;S(0.996)PS(0.004)VAAMASPQLCR;S(0.917)PS(0.083)VAAMASPQLCR;S(0.787)PS(0.213)VAAMASPQLCR 196.37 0.00011754 112425400.0 44509.4 33982.4 51692.2 55643.7 55459.6 42299.7 45531.7 59604.9 35772.2 45251.1 True False 42035.745733245414 36588.74080936192 48366.380130211866 48064.9320692635 48492.26923288535 48126.099716554665 47649.014269351945 59778.34039087764 42927.639558779294 43944.58316652249 0.956562622836954 0.8326109425299012 1.100622116426353 1.0937623844815518 1.103486840440151 1.095154311378648 1.0842977868009802 1.36031192204862 0.9768584991717951 1.0 15.423397721927822 -5.275899660165079 21.40736770072785 1.1135891969852412 0.8945868987066016 0.3985465026479872 0.10100150659687153 92.67337888683598 137197.59919669986 0.025439733583233315 0.05355762175893252 5.297858320054925e-06 5.275899660165079 -0.2190022982786396 S(ph)PSVDSAR ddPTM_A459_Selumetinib_30min_R2 1 SPSVDSAR 8 0 C9JJX6;E9PDC3;O00192-2;O00192 C9JJX6 ARVCF Armadillo repeat protein deleted in velo-cardio-facial syndrome 1 S(1)PSVDSAR 104.42 0.013081 0.0 6089.6 4718.4 8022.9 6028.2 8478.9 6142.7 6989.7 6786.2 5445.8 8017.2 True False 5751.164410600263 5080.286107952744 7506.715348673051 5207.14876077497 7413.7047796722545 6988.801167121287 7314.7348998277985 6805.946718484112 6535.112168365388 7785.722604812793 0.7386808781300717 0.6525131148151019 0.9641642439242221 0.6688073830881334 0.9522179450741575 0.897643227463706 0.9395062309702826 0.874157360073036 0.8393713082361383 1.0 12.926615228911873 -2.9536147650835196 0.2957201198159436 0.9398917596098139 3.939949160704395e-13 0.38214652002825567 0.0933731772644476 24.274781609678726 0.7309679891741737 0.09608743571856757 10.144268159320635 0.0011127183110447387 2.9536147650835196 -0.9398917596094198 S(ph)PSWQRPNQGVPSTGR ddPTM_A459_Selumetinib_30min_R1 2 SPSWQRPNQGVPSTGR 16 1 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4;Q96HC4-6;A0A0A0MSP3 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 S(0.97)PS(0.03)WQRPNQGVPSTGR;S(0.919)PS(0.081)WQRPNQGVPSTGR 146.1 0.001691 23623000.0 1796.65 2680.6000000000004 1633.77 1977.98 1986.2200000000003 1777.58 2364.8999999999996 2150.35 1425.8400000000001 1954.3899999999999 True False 1838.5084493276656 2366.7541058228694 1411.9130076562271 1632.5629242831064 1806.5667516956223 1759.6991591135052 2186.5136890080857 2093.3157326787978 2419.546340766706 2205.2549938707098 0.8336942686617284 1.07323375863609 0.640249318822767 0.7403057373503995 0.8192099130108752 0.7979572267172806 0.9915015248056512 0.9492397652411915 1.0971730468773897 1.0 11.106729769072095 -7.295069725298215 5.794219280753517 1.0069694598369066 0.8174405268768961 0.43465185608832857 0.10730360304325544 0.20982534111402407 21.21827304036006 0.047198087456561365 0.03223743960070183 5.069093182450087e-08 7.295069725298215 -0.1895289329600105 S(ph)PSWTAPPVIALQNGLSEDEALQR ddPTM_A459_Selumetinib_30min_R2 1 SPSWTAPPVIALQNGLSEDEALQR 24 0 A0A087X0D9;E9PFU9;Q8WV99 A0A087X0D9 ZFAND2B AN1-type zinc finger protein 2B 1 S(0.485)PS(0.485)WT(0.03)APPVIALQNGLSEDEALQR 99.753 0.00029130000000000003 0.0 2590.9 1185.9 2776.6 2743.6 3074.9 1944.1 2320.7 2403.3 2160.7 2625.5 True False 2446.908150194466 1276.8547167304923 2597.956578933502 2369.9169470260126 2688.6035720452214 2211.882128217314 2428.6171483798116 2410.293205112266 2592.9003750022202 2549.694993131766 0.9596866122362944 0.5007872393247099 1.0189283761123353 0.929490371754257 1.0544804689532044 0.8675085193231212 0.9525128122861333 0.9453260925738126 1.0169453138461026 1.0 11.316108959897372 -5.295315389677574 24.99736080961806 0.9680319521956694 0.7302367070347617 0.41807441199785667 0.11450740156909651 472.2284570043342 348460.0864224374 0.027303883464275223 0.05684260073108186 5.06622659413285e-06 5.295315389677574 -0.23779524516090766 S(ph)PSYTNDSTATFIIDGMHCK ddPTM_A459_Selumetinib_30min_R2 2 SPSYTNDSTATFIIDGMHCK 20 0 Q04656-5;Q04656;Q04656-2;Q04656-3 Q04656-5 ATP7A Copper-transporting ATPase 1 1 S(0.407)PS(0.407)Y(0.08)T(0.099)NDS(0.004)T(0.003)ATFIIDGMHCK;S(0.394)PS(0.312)Y(0.242)T(0.05)NDS(0.003)TATFIIDGMHCK 128.38 0.00012635 10835500.0 112891.0 53356.0 89126.0 99684.0 71686.0 54964.0 96140.0 88438.0 77336.0 70743.0 True False 106616.97015847899 57448.23363341946 83391.7301930516 86106.86723550835 62680.1637990288 62534.79208648547 100610.700497796 88695.33993830085 92805.3609483833 68700.46577761203 1.5519104412422065 0.8362131607576463 1.2138451937574364 1.25336657125793 0.9123688331594236 0.9102528109331128 1.4644835280080855 1.2910442299680116 1.3508694576948055 1.0 16.068032259855897 -7.2664400275868015 24.987208708751876 1.3008529782412044 1.1022574918713512 0.10884049517809413 0.22384414300601105 823.6562424346752 4115617.5749410857 0.08880666235684215 0.061903897128495276 5.4145201268680135e-08 7.2664400275868015 -0.19859548636985314 S(ph)PTAALNESLVECPK ddPTM_A459_Selumetinib_30min_R1 2 SPTAALNESLVECPK 15 0 Q53EZ4 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 S(0.994)PT(0.006)AALNESLVECPK;S(1)PTAALNESLVECPK 177.44 1.9512e-05 75442000.0 6864.2 7347.4 5934.8 5594.6 6152.1 5959.2 9139.6 8017.299999999999 4448.9 6963.700000000001 True False 7024.122504591856 6487.162992286407 5128.8867575228915 4617.608133648608 5595.643641241472 5899.255858520684 8450.19261366583 7804.655160139387 7549.458365200157 7857.558727182119 0.8939319130117211 0.8255952284320802 0.6527328570615998 0.587664476203613 0.7121351345277421 0.7507746443068938 1.0754221389951026 0.9932671751011266 0.960789302036505 1.0 12.939865434390255 -7.221911296097295 7.910555563955821 1.006707075518101 0.7288713503343299 0.7137746935206364 0.08374074583133312 0.17286487266599826 31.564528646996667 0.036042011125657775 0.027663912695636318 5.999135950653313e-08 7.221911296097295 -0.277835725183771 S(ph)PTAALNESLVECPK ddPTM_A459_Selumetinib_30min_R2 4 SPTAALNESLVECPK 15 0 Q53EZ4 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 S(0.614)PT(0.386)AALNESLVECPK;S(0.987)PT(0.013)AALNESLVECPK;S(0.999)PT(0.001)AALNESLVECPK;S(1)PTAALNESLVECPK 214.54 2.9938e-07 94379200.0 136359.0 109691.0 130828.0 145013.0 127185.0 107137.0 129453.0 137385.0 116510.0 126894.0 True False 128780.71266832645 118103.94698784447 122410.668914756 125261.97923862192 111206.88325167375 121894.14925714629 135472.82100625327 137784.7676046889 139815.25556139587 123230.24050979324 1.045041477932457 0.958400685572456 0.9933492656376653 1.0164873388254665 0.9024317634342036 0.9891577647895545 1.0993472093036052 1.1181084045173069 1.1345855934630316 1.0 16.91099680904084 -7.248660189982243 6.315757514265155 1.0981648901681245 0.9808287039756167 0.5187993139575987 0.04858028998429318 0.1141131271679827 21.39343689511897 0.018816316054525502 0.013849963138531316 5.640788418869451e-08 7.248660189982243 -0.11733618619250774 S(ph)PTDDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R1 2 SPTDDEVTPSAVVR 14 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(0.997)PT(0.003)DDEVTPSAVVR;S(1)PTDDEVTPSAVVR 183.06 7.6666e-05 10706400.0 691.64 816.78 942.56 651.13 810.99 847.78 899.65 766.52 561.74 577.65 True False 707.7538663028341 721.15101788928 814.5655291114743 537.4223687238799 737.6360976919136 839.2521029226513 831.7886761876297 746.1893995921374 953.2317521336826 651.7970042874837 1.0858501368482356 1.1064043147568792 1.2497227261759545 0.8245241466112089 1.131696053893751 1.287597361451646 1.2761468228853017 1.1448187007361892 1.462467218878544 1.0 9.348278911121648 -6.588764791727935 6.03752305209958 1.243947142779596 1.0702547010061063 0.22537309238653913 0.1464190133428152 0.29453812955949893 19.95275406179963 0.047027438217514796 0.047126538785287435 2.577716837113233e-07 6.588764791727935 -0.17369244177348975 S(ph)PTDDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R2 1 SPTDDEVTPSAVVR 14 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 S(0.999)PT(0.001)DDEVTPSAVVR 170.26 3.4424e-07 0.0 3996.1 5285.8 3349.9 1711.8 4414.6 1819.5 4374.5 4635.1 3120.3 5120.3 True False 3774.0127596557595 5691.2038634741875 3134.371081095344 1478.6498869802926 3859.9984809752614 2070.1196092234964 4577.9229179073045 4648.587373617885 3744.4471884664363 4972.463634862915 0.7589824756475679 1.144544089487562 0.6303457021022045 0.2973676623018797 0.7762748537590215 0.4163166915308305 0.9206548813772296 0.9348660372346878 0.753036615936894 1.0 12.279745104892594 S(ph)PTEDFR ddPTM_A459_Selumetinib_30min_R1 1 SPTEDFR 7 0 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(0.997)PT(0.003)EDFR 112.41 0.014575 67887000.0 3294.6 4359.0 2973.6 2569.4 3335.4 2871.5 4083.8 4117.3 2067.6 4026.0 True False 3371.357769824354 3848.6462535558785 2569.8014528156077 2120.702523611471 3033.7136589126994 2842.615317113396 3775.7556781137564 4008.0958291247566 3508.5661884708256 4542.7763165609085 0.7421359835688822 0.8472013555951355 0.5656896298079378 0.4668296160390615 0.6678104858152824 0.625744064648419 0.8311559748933837 0.8823009432608538 0.7723396319735532 1.0 12.149358554412208 -7.3360787874179545 4.353529571778111 0.8675168053502624 0.6495352790383258 0.4988883427623141 0.10781674898233991 0.22383341292668613 8.064937865468453 0.05088585347488268 0.03377043323148668 4.612338923460789e-08 7.3360787874179545 -0.21798152631193668 S(ph)PTEDFR ddPTM_A459_Selumetinib_30min_R2 2 SPTEDFR 7 0 Q8IXT5 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(0.925)PT(0.075)EDFR;S(0.946)PT(0.054)EDFR 86.67 0.034599 134278600.0 92211.0 67190.0 78704.0 81846.0 98743.0 75295.0 87487.0 85011.0 78775.0 72011.0 True False 87086.28176987999 72343.25695009854 73640.27032643594 70698.43360777496 86338.02156637982 85666.20279004307 91555.31885220176 85258.36793567131 94532.20115740255 69931.85532295254 1.245302035355798 1.0344821629000103 1.0530289806606383 1.0109617896062142 1.2346021876248228 1.224995424394615 1.309207634051604 1.2191635348717598 1.3517759641989058 1.0 16.0936621605806 -6.280288768911448 22.90685750986413 1.238630089272207 1.0799168753435484 0.2840245604128011 0.10497757136954065 301.77178074680796 366728.88041626074 0.030979469756742276 0.0352102282613893 5.244586238882733e-07 6.280288768911448 -0.15871321392865867 S(ph)PTFSEELPVLGDGQQLR ddPTM_A459_Selumetinib_30min_R1 4 SPTFSEELPVLGDGQQLR 18 0 Q8N0Z3 Q8N0Z3 SPICE1 Spindle and centriole-associated protein 1 1 S(1)PTFSEELPVLGDGQQLR;S(0.991)PT(0.009)FSEELPVLGDGQQLR;S(0.997)PT(0.003)FSEELPVLGDGQQLR;S(0.999)PT(0.001)FSEELPVLGDGQQLR 268.08 7.1059e-54 40611500.0 1281.4299999999998 1570.02 1568.77 1537.82 1845.05 1345.7900000000002 1386.0300000000002 1635.88 882.3599999999999 1083.0300000000002 True False 1311.2848257712687 1386.2013285175046 1355.739650636785 1269.268605456601 1678.1655532700343 1332.2525744795523 1281.4806412008447 1592.4911483128756 1497.300474975391 1222.0474501055546 1.073022840199868 1.1343269268290452 1.1094001714251625 1.038641016228108 1.3732409106741987 1.090180724459168 1.0486341108032724 1.3031336452404723 1.2252392285144584 1.0 10.255084588397239 S(ph)PTFSEELPVLGDGQQLR ddPTM_A459_Selumetinib_30min_R2 4 SPTFSEELPVLGDGQQLR 18 0 Q8N0Z3 Q8N0Z3 SPICE1 Spindle and centriole-associated protein 1 1 S(0.932)PT(0.067)FS(0.001)EELPVLGDGQQLR;S(0.997)PT(0.003)FSEELPVLGDGQQLR;S(0.909)PT(0.087)FS(0.004)EELPVLGDGQQLR;S(0.912)PT(0.087)FS(0.001)EELPVLGDGQQLR 178.02 1.8953e-09 23440700.0 9514.369999999999 9807.58 10760.02 11412.2 11140.779999999999 8922.33 5677.5 5166.1 5458.799999999999 7965.5 True False 8985.59940444082 10559.789849659872 10067.732027823979 9857.838672856928 9741.175616563125 10151.299968652425 5941.514999752823 5181.132495706106 6550.712531615733 7735.51531814553 1.1616032073988547 1.3651048980394778 1.3014946792500905 1.2743609530101987 1.2592794682615174 1.3122978303514035 0.76808263643607 0.6697850476169961 0.8468359588467811 1.0 12.917281687799788 -7.261714547920424 24.9984387108957 0.7936579763704841 1.2828483341532833 0.8551165355024312 0.09203942299372203 7.997439375926245 726497.0494324765 0.03520511393164059 0.02542688591965305 5.473756224748373e-08 7.261714547920424 0.4891903577827992 S(ph)PTGNTPPVIDSVSEK ddPTM_A459_Selumetinib_30min_R1 3 SPTGNTPPVIDSVSEK 16 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.921)PT(0.079)GNTPPVIDSVSEK;S(0.999)PT(0.001)GNTPPVIDSVSEK;S(0.999)PT(0.001)GNTPPVIDSVSEK 259.14 5.1786e-39 19763500.0 5594.7 6732.400000000001 4339.07 3714.3199999999997 4295.41 4112.66 5591.29 5160.1 2729.33 4609.53 True False 5725.045624608852 5944.167478192155 3749.8481268054306 3065.683738421637 3906.8909239162303 4071.290374396507 5169.534493726597 5023.237385632974 4631.473667623854 5201.208076124443 1.1007145918443497 1.1428436223265481 0.7209571453252723 0.5894176302029351 0.751150668601468 0.7827586043106609 0.9939103412256779 0.9657828166290013 0.8904611389965554 1.0 12.344631039263797 -9.555965996506622 18.077226024830765 0.9999999999999946 0.8753179560884956 0.04233343998528516 0.16565083501880254 0.0 0.0 0.18017244258722115 0.04369823597721451 2.7799309165344714e-10 9.555965996506622 -0.12468204391149895 S(ph)PTGNTPPVIDSVSEK ddPTM_A459_Selumetinib_30min_R2 2 SPTGNTPPVIDSVSEK 16 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.884)PT(0.116)GNTPPVIDSVSEK;S(1)PTGNTPPVIDSVSEK 249.89 2.1956999999999996e-29 24024000.0 46621.0 40018.0 46027.0 51928.0 52153.0 41112.0 55385.0 54001.0 52319.0 45355.0 True False 44029.991458649965 43087.25192184911 43065.672930408495 44855.31681920353 45601.073886264385 46774.8048224218 57960.51224329547 54158.13396965322 62784.26191500028 44045.48330355791 0.9996482761966494 0.9782445029583454 0.9777545777759631 1.0183863010439531 1.0353178229873305 1.0619659795773753 1.315924083380725 1.2295956340494607 1.425441548280813 1.0 15.426706463402214 -7.12439037776456 3.7686938773445333 1.261488847188981 1.00302223931433 0.5561728916898963 0.10131587963268676 0.16347318655818813 4.109286280412235 0.03817774645643401 0.029131909124629714 7.509475802762674e-08 7.12439037776456 -0.2584666078746509 S(ph)PTGPSNSFLANMGGTVAHK ddPTM_A459_Selumetinib_30min_R1 6 SPTGPSNSFLANMGGTVAHK 20 0 H0Y6J6;Q5W012;Q96I25 H0Y6J6 RBM17 Splicing factor 45 1 S(0.935)PT(0.059)GPS(0.004)NS(0.002)FLANMGGTVAHK;S(0.333)PT(0.333)GPS(0.333)NSFLANMGGTVAHK;S(0.777)PT(0.209)GPS(0.013)NS(0.001)FLANMGGTVAHK;S(0.636)PT(0.32)GPS(0.034)NS(0.01)FLANMGGTVAHK;S(0.968)PT(0.028)GPS(0.003)NS(0.001)FLANMGGTVAHK;S(0.974)PT(0.026)GPSNSFLANMGGTVAHK 219.65 1.1232000000000003e-19 1567628000.0 15753.54 19866.29 14011.07 14319.3 16803.46 14836.72 19096.93 16703.5 7570.230000000001 15586.289999999999 True False 16120.566830947242 17540.33553121234 12108.443651298492 11818.703061551223 15283.590009891821 14687.476067463922 17656.433195073445 16260.468919385366 12846.127402276798 17586.942144821205 0.9166213602228876 0.9973499308051917 0.6884905603026643 0.6720158037838008 0.8690305502820086 0.8351352922252556 1.0039512866807663 0.92457624443676 0.7304355297523721 1.0 14.102217041665748 -7.036962235660127 23.07404850567574 0.9100394867122251 0.8246272703728275 0.11562852995462036 0.11466139875101185 581.2933565389487 362875.4959107146 0.046750540319433306 0.03623064415318664 9.184124541230374e-08 7.036962235660127 -0.08541221633939766 S(ph)PTGPSNSFLANMGGTVAHK ddPTM_A459_Selumetinib_30min_R2 10 SPTGPSNSFLANMGGTVAHK 20 0 H0Y6J6;Q5W012;Q96I25 H0Y6J6 RBM17 Splicing factor 45 1 S(0.949)PT(0.046)GPS(0.004)NS(0.001)FLANMGGTVAHK;S(0.736)PT(0.211)GPS(0.023)NS(0.03)FLANMGGTVAHK;S(0.565)PT(0.427)GPS(0.007)NSFLANMGGTVAHK;S(0.929)PT(0.039)GPS(0.03)NS(0.002)FLANMGGTVAHK;S(0.588)PT(0.208)GPS(0.158)NS(0.046)FLANMGGTVAHK;S(0.964)PT(0.033)GPS(0.004)NSFLANMGGTVAHK;S(0.812)PT(0.154)GPS(0.031)NS(0.002)FLANMGGTVAHK;S(0.813)PT(0.18)GPS(0.007)NSFLANMGGTVAHK;S(0.817)PT(0.155)GPS(0.026)NS(0.002)FLANMGGTVAHK;S(0.511)PT(0.345)GPS(0.142)NS(0.003)FLANMGGTVAHK 200.57 6.442599999999998e-16 741718700.0 589736.0 519434.0 604706.0 690975.0 703046.0 555916.0 621566.0 636104.0 594772.0 581270.0 True False 556960.8340202564 559272.9175564434 565799.8743141115 596863.0130016394 614723.076169015 632488.3828969995 650470.0506096637 637954.957327314 713743.0193181927 564487.224779167 0.9866668536885755 0.9907627542416686 1.0023253839543633 1.0573543329260253 1.0889937791054543 1.1204653624259349 1.152320233401445 1.130149504405327 1.264409517146143 1.0 19.106581405379643 -6.19800465389629 1.0426194370522641 1.1477685266877549 0.982747893396743 0.504353641323785 0.06018731083690107 0.4001335349624673 0.9067777829634865 0.025052294311225617 0.04127833380840924 6.338629187504257e-07 6.19800465389629 -0.1650206332910119 S(ph)PTHLTVSSTNTLR ddPTM_A459_Selumetinib_30min_R2 1 SPTHLTVSSTNTLR 14 0 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 S(0.5)PT(0.5)HLTVSSTNTLR 90.861 0.011716 6547100.0 5292.5 5448.6 4832.5 7161.9 7886.9 4872.7 5437.7 7072.9 5586.3 6025.8 True False 4998.364037556144 5866.490099989684 4521.582211228175 6186.43686503339 6896.077112219406 5543.870195033438 5690.563824598136 7093.480968018373 6703.7160942633855 5851.819497091368 0.8541555391516378 1.0025070156223388 0.7726797132884252 1.0571817651088422 1.1784500727760117 0.9473754612200538 0.9724434985437634 1.2121838295839729 1.1455780715033077 1.0 12.514669554024445 -5.876904209673231 7.857834844982215 1.0786806093130954 0.8897533158194655 0.4610205680842153 0.09733458529409621 0.22317227282147498 14.419388455002515 0.02824265325609265 0.04206877020168664 1.327687267281326e-06 5.876904209673231 -0.1889272934936299 S(ph)PTKAPHLQLIEGK ddPTM_A459_Selumetinib_30min_R1 1 SPTKAPHLQLIEGK 14 1 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 S(0.5)PT(0.5)KAPHLQLIEGK 67.234 0.028625 17827000.0 10765.0 12829.0 10109.0 9372.2 10405.0 9564.2 10119.0 10468.0 6753.6 9648.2 True False 11015.803554956352 11326.974715959705 8736.253324762236 7735.521207982957 9463.86958715195 9467.992831598795 9355.715683146356 10190.354635143893 11460.36593657214 10886.640451426474 1.0118643675343346 1.0404472129393723 0.8024746811232777 0.7105517301225258 0.8693103836190256 0.8696891271317962 0.8593758308533538 0.9360421776222666 1.052699957136041 1.0 13.410271195694598 -8.048218764470906 3.6188403681096686 1.0241196758815354 0.8767226894629435 0.29276346158773514 0.08957211947595639 0.3380615945866662 8.755956650933008 0.0738429958373293 0.02656277221077379 8.949138625737388e-09 8.048218764470906 -0.1473969864185919 S(ph)PTKAPHLQLIEGK ddPTM_A459_Selumetinib_30min_R2 1 SPTKAPHLQLIEGK 14 1 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 S(0.5)PT(0.5)KAPHLQLIEGK 70.373 0.024752 31221000.0 361960.0 290220.0 394630.0 393030.0 321080.0 275580.0 314430.0 413480.0 262070.0 339430.0 True False 341843.712240684 312478.94079561834 369239.9354406559 339498.63598543376 280743.0599083805 313538.64353383455 329051.61803122534 414683.1583447006 314491.32284761034 329629.773954947 1.0370535044185856 0.947969405331471 1.12016560582638 1.0299392312535323 0.8516920560299622 0.9511842324555555 0.9982460445948651 1.2580270082076337 0.9540743819173151 1.0 18.330487034910426 -7.560898088513276 24.999658755034037 1.0892577581765712 0.9880500796376364 0.11234370549858474 0.09894147919476387 290.94367909620723 191307.22884473344 0.046156749749128305 0.026648662713775337 2.7485390492501758e-08 7.560898088513276 -0.10120767853893486 S(ph)PTKGEDWETLK ddPTM_A459_Selumetinib_30min_R2 1 SPTKGEDWETLK 12 1 Q4KWH8-2;A0A2U3TZV8;Q4KWH8 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 S(0.5)PT(0.5)KGEDWETLK 84.479 0.017913 6221300.0 52733.0 38896.0 47371.0 50309.0 42421.0 40817.0 50564.0 55793.0 42674.0 46280.0 True False 49802.31096692451 41879.19812964771 44323.20143364509 43456.8274121343 37091.6947314483 46439.17125016516 52915.32619066521 55955.34839297164 51209.99241118375 44943.77615011927 1.108102505685703 0.9318130721763256 0.9861921990176934 0.9669153581350545 0.8252910171044865 1.0332725736050978 1.1773671623390012 1.2450077226727008 1.1394234485356622 1.0 15.455833723563986 -7.104432287753943 4.311379718382324 1.1593112610180492 0.9606086153653384 0.4705913780222316 0.08703600862381933 0.1821160051890732 5.70839054908735 0.03370065269485695 0.026006634775596317 7.862627703431786e-08 7.104432287753943 -0.19870264565271079 S(ph)PTLGIAR ddPTM_A459_Selumetinib_30min_R1 1 SPTLGIAR 8 0 F5GX58;F8WDL1;Q99618;J3KMY0 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 S(0.96)PT(0.04)LGIAR 89.88600000000002 0.02904 3205000.0 3391.9 3172.4 2420.2 2361.3 1473.3 3174.5 2868.4 2350.8 1599.0 1928.0 True False 3470.9246705115133 2800.973933191251 2091.5501332070007 1948.943282090668 1340.0402751322413 3142.567412215383 2652.0342786379124 2288.449147525434 2713.386213660694 2175.4775803103403 1.5954771043957956 1.2875213969300852 0.9614211390349667 0.8958691644216548 0.6159752172399218 1.4445413920409529 1.2190584277405376 1.0519295479013753 1.2472600215322003 1.0 11.08711643372083 -4.921636816810642 2.9503501246158774 1.0559787679849562 1.6140332916285214 0.3879350915271922 0.21174210801280385 0.34008301179516953 5.150373335423551 0.05858021172996686 0.3881105376862434 1.197741736356339e-05 4.921636816810642 0.5580545236435652 S(ph)PTLGIAR ddPTM_A459_Selumetinib_30min_R2 2 SPTLGIAR 8 0 F5GX58;F8WDL1;Q99618;J3KMY0 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 S(0.998)PT(0.002)LGIAR;S(0.997)PT(0.003)LGIAR 99.013 0.018995 37367000.0 27959.0 12541.099999999999 22591.0 23373.0 21837.5 18842.9 26684.0 19241.2 19365.4 18331.4 True False 26405.150708744866 13502.962044007736 21137.51965522104 20189.557079326074 19094.07802027301 21438.338436184364 27924.858873342913 19297.188706447858 23239.021114485113 17802.12485130285 1.483258371082169 0.758502827993565 1.1873593647824623 1.1341093969380007 1.0725729754038662 1.2042572791312267 1.568625043728936 1.0839823261342643 1.305407152718871 1.0 14.119761830262531 -6.990151898605793 16.815730889156143 1.26649151269911 1.1132070911281822 0.05042537226287569 0.21620964127910716 9.65153820265637 16473.18753657631 0.07261925578478086 0.06369916564629949 1.0229351484541621e-07 6.990151898605793 -0.15328442157092792 S(ph)PTLSCR ddPTM_A459_Selumetinib_30min_R2 2 SPTLSCR 7 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 S(0.999)PT(0.001)LSCR;S(0.996)PT(0.004)LSCR 82.75 0.040577 5472900.0 5860.799999999999 2304.61 8803.599999999999 9065.8 10606.099999999999 3597.4 8214.9 6455.200000000001 6064.1 4479.5 True False 5535.080198641288 2481.3661765108877 8237.185960634935 7831.022400622693 9273.66689826297 4092.9091960541978 8596.909127515532 6473.98356328411 7277.089445110824 4350.165195861265 1.2723839094449443 0.5704073442708918 1.8935340589989023 1.8001666713882742 2.131796490644979 0.9408629354922384 1.976225899580689 1.4882155669498345 1.6728305977975795 1.0 12.086854472456688 -5.2663761934604985 24.989255177401887 1.644577298125784 0.9213956193993494 0.3190792110977416 0.4019810563627429 391.74276031328384 1982939.9945286885 0.09928492125600374 0.2175214925625734 5.415316030519423e-06 5.2663761934604985 -0.7231816787264346 S(ph)PTLSQVHSPLVT(ph)SPSANLK ddPTM_A459_Selumetinib_30min_R2 1 SPTLSQVHSPLVTSPSANLK 20 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 2 S(0.901)PT(0.071)LS(0.028)QVHSPLVT(0.568)S(0.318)PS(0.114)ANLK 99.836 0.0020208 0.0 9695.2 8952.6 9173.8 10139.0 13957.0 11887.0 11259.0 11197.0 9678.0 10200.0 True False 9156.379596960658 9639.235632853874 8583.567695678224 8758.05070924943 12203.59688283689 13524.326350557696 11782.56580928526 11229.581416236866 11613.870425913587 9905.499497217295 0.9243733341799589 0.973119592359959 0.8665456697150472 0.884160431456262 1.2320021707401214 1.365335120592053 1.1894973910801045 1.1336713932893074 1.172466913877106 1.0 13.274014011315353 -6.260875321599087 24.99993450080453 1.198371149721283 0.9131615862154366 0.6843681867457997 0.08945934524519769 29.17789772909359 1293204.3052800505 0.027763956658278667 0.033717451641161654 5.484343883081427e-07 6.260875321599087 -0.28520956350584636 S(ph)PTMEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R1 8 SPTMEQAVQTASAHLPAPAAVGR 23 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.596)PT(0.404)MEQAVQTASAHLPAPAAVGR;S(0.5)PT(0.5)MEQAVQTASAHLPAPAAVGR;S(0.5)PT(0.5)MEQAVQTASAHLPAPAAVGR;S(0.803)PT(0.197)MEQAVQTASAHLPAPAAVGR;S(0.555)PT(0.443)MEQAVQTAS(0.002)AHLPAPAAVGR;S(0.872)PT(0.128)MEQAVQTASAHLPAPAAVGR;S(0.965)PT(0.035)MEQAVQTASAHLPAPAAVGR;S(0.988)PT(0.012)MEQAVQTASAHLPAPAAVGR 214.27 1.0448e-24 636663700.0 7000.67 9627.359999999999 8224.59 8689.15 8450.67 7387.610000000001 9363.63 8318.05 3940.7200000000003 6936.6799999999985 True False 7163.7719900674665 8500.184215561758 7107.73585243904 7171.75306804647 7686.308390586967 7313.2973508131945 8657.323850398241 8097.428293165706 6687.114021198852 7827.070446985024 0.915255846819028 1.0859981743023683 0.9080965733708107 0.9162755230865487 0.9820159972557448 0.9343594644188064 1.106074604673199 1.0345413840353033 0.8543572038213504 1.0 12.934256714470072 S(ph)PTMEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R2 14 SPTMEQAVQTASAHLPAPAAVGR 23 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.955)PT(0.045)MEQAVQTASAHLPAPAAVGR;S(0.635)PT(0.365)MEQAVQTASAHLPAPAAVGR;S(0.5)PT(0.5)MEQAVQTASAHLPAPAAVGR;S(0.782)PT(0.218)MEQAVQTASAHLPAPAAVGR;S(0.968)PT(0.032)MEQAVQTASAHLPAPAAVGR;S(0.5)PT(0.5)MEQAVQTASAHLPAPAAVGR;S(0.879)PT(0.121)MEQAVQTASAHLPAPAAVGR;S(0.784)PT(0.216)MEQAVQTASAHLPAPAAVGR;S(0.5)PT(0.5)MEQAVQTASAHLPAPAAVGR;S(0.812)PT(0.188)MEQAVQTASAHLPAPAAVGR;S(0.793)PT(0.207)MEQAVQTASAHLPAPAAVGR;S(0.955)PT(0.045)MEQAVQTASAHLPAPAAVGR;S(0.942)PT(0.058)MEQAVQTASAHLPAPAAVGR;S(0.811)PT(0.189)MEQAVQTASAHLPAPAAVGR 162.35 9.1819e-13 787577500.0 265228.1 206606.3 301256.4 341393.19999999995 376427.1 281011.5 275916.4 319109.8 320321.6 304209.39999999997 True False 250487.78399420786 222452.3388660381 281873.89120716805 294894.8572238818 329136.9623970284 319718.2833565865 288747.0593179745 320038.35668652866 384394.8705333038 295426.0841910558 0.8478864846348985 0.7529881441415828 0.9541266201290358 0.9982018278154802 1.1141093492075376 1.0822276720488249 0.9773918918115507 1.0833111015327808 1.3011541333117722 1.0 18.172437686699716 -5.631161220791829 1.6166112397116295 1.0902484204473104 0.7942428235339448 0.6245546204943229 0.0872902686749462 0.2601716439987621 1.344622269517862 0.02759061555228501 0.07144700176843849 2.3379691658947533e-06 5.631161220791829 -0.2960055969133656 S(ph)PTNSLLK ddPTM_A459_Selumetinib_30min_R1 1 SPTNSLLK 8 0 Q14106-2;Q14106 Q14106-2 TOB2 Protein Tob2 1 S(0.998)PT(0.002)NSLLK 85.29 0.035480000000000005 4009500.0 2186.6 2152.2 2397.4 2260.5 2345.8 2229.2 2303.5 2043.0 1265.6 1590.6 True False 2237.5435256170513 1900.2194234693654 2071.8462479755644 1865.746109840323 2133.6228041846284 2206.7762719516545 2129.7451404415115 1988.813003400743 2147.6307642332545 1794.7690037560305 1.246702790684705 1.058754312946486 1.1543804487595206 1.0395466524860604 1.1888007870201995 1.229560053317942 1.1866402506308358 1.108116420129066 1.1966056688848354 1.0 10.80958245819192 -10.586960377668346 4.08272866485991 0.9999781542532925 1.1527388552656783 0.3390853359771878 0.06537905479531521 8135028.4947377 5273754.0814754795 1501.3887868149704 0.015776561016773077 2.588449058399186e-11 10.586960377668346 0.1527607010123858 S(ph)PTNSLLK ddPTM_A459_Selumetinib_30min_R2 1 SPTNSLLK 8 0 Q14106-2;Q14106 Q14106-2 TOB2 Protein Tob2 1 S(1)PTNSLLK 99.788 0.018368 8740200.0 40032.0 35943.0 38671.0 39786.0 37998.0 34852.0 30797.0 33014.0 26985.0 37541.0 True False 37807.18170079312 38699.712525039315 36182.94996180126 34367.07816532183 33224.35153356998 39652.54664504389 32229.121523097783 33110.0652742381 32382.7540238973 36457.09378676809 1.0370322418435622 1.0615139196609569 0.9924803708553882 0.9426719081430232 0.9113274834218569 1.0876496869708132 0.884028817864664 0.9081926680139057 0.8882428811604959 1.0 15.153911939650337 -5.50895021872121 2.9297431502297147 0.9441302257615561 1.0489824671607306 0.3374751018596749 0.05766027457778137 0.29910020036360857 5.153483279656956 0.01649873866588232 0.03630823591825652 3.0977743632058583e-06 5.50895021872121 0.10485224139917448 S(ph)PTPALCDPPACSLPVASQPPQHLSEAGR ddPTM_A459_Selumetinib_30min_R2 2 SPTPALCDPPACSLPVASQPPQHLSEAGR 29 0 Q9P2R6;A0A590UJ84;A0A590UK57;H7BYW9 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 S(0.5)PT(0.5)PALCDPPACSLPVASQPPQHLSEAGR;S(0.5)PT(0.5)PALCDPPACSLPVASQPPQHLSEAGR 75.661 3.9135e-05 20816400.0 13132.9 8191.5 20907.2 27828.0 35958.0 20257.2 11273.29 18890.3 24864.3 18607.0 True False 12403.025993164116 8819.761710176092 19562.053514038224 24037.778394022425 31440.634571401348 23047.44542344723 11797.520322600356 18945.267645542477 29837.85476658847 18069.767563208068 0.6863965432747442 0.4880949176199724 1.0825846788349733 1.330276015446145 1.739957886089125 1.2754699440835218 0.6528872206757843 1.0484510981821935 1.6512583608071116 1.0 14.141290328056124 -5.3811813060296485 4.061431765058173 1.2401295807241601 0.5891926643337553 0.4266019404255387 0.29864230567285327 0.22649507349801323 6.292791422727589 0.08623841572365881 0.19322244420591572 4.157370154643565e-06 5.3811813060296485 -0.6509369163904049 S(ph)PTPESSTIASYVTLR ddPTM_A459_Selumetinib_30min_R1 1 SPTPESSTIASYVTLR 16 0 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 S(1)PTPESSTIASYVTLR 155.37 9.1547e-05 10239000.0 337.76 371.14 265.8 224.21 248.22 276.52 194.69 283.83 208.86 313.75 True False 345.62915083344683 327.6867562616949 229.70581993488997 185.0559324429546 225.76854482680037 273.7384598600716 180.00437655418173 276.30190639022635 354.4201654691509 354.0228686838015 0.9762904642811321 0.9256090079151668 0.6488445811110967 0.5227231029762625 0.6377230535026466 0.7732225346847957 0.5084540928765654 0.7804634412953919 1.0011222348059787 1.0 8.467698746329003 -8.192574460012233 4.061315059073864 1.004457469162529 0.7076071915597035 0.37949255168990725 0.1440436892983445 0.24616954309210168 7.645717960878454 0.12340686840290763 0.04070931249610244 6.4183816858995766e-09 8.192574460012233 -0.29685027760282545 S(ph)PTPESSTIASYVTLR ddPTM_A459_Selumetinib_30min_R2 3 SPTPESSTIASYVTLR 16 0 A0JP02;B4DJX4;Q9HAU0-8;Q9HAU0;Q9HAU0-2;Q9HAU0-4;Q9HAU0-6;Q9HAU0-5;H0YGJ6 A0JP02 PLEKHA5 Pleckstrin homology domain-containing family A member 5 1 S(0.998)PT(0.002)PESSTIASYVTLR;S(0.996)PT(0.004)PESSTIASYVTLR;S(1)PTPESSTIASYVTLR 147.83 0.000306 11256900.0 6870.2 3738.3 7965.7 6421.5 9432.1 7330.9 4347.3 9319.8 6079.3 9533.8 True False 6488.381787589643 4025.0155894709487 7453.195534398398 5546.880622294626 8247.155273956143 8340.664931715606 4549.458064011529 9346.919075024052 7295.329869834308 9258.53442221277 0.7008000933736264 0.4347357158185063 0.8050081356847297 0.5991100069776415 0.8907625006145509 0.9008623342918031 0.4913799373145516 1.0095462898101057 0.7879573091321661 1.0 13.176568125108219 -3.927571664156629 0.12309011000451647 1.0972413645361248 4.2861720736514695e-15 0.3093511012233958 0.15919053551715096 58.54774741044831 0.9152547896689274 1.2887389541044314 10.69610595210117 0.00011814853362327797 3.927571664156629 -1.0972413645361205 S(ph)PTPPLFSLPEAR ddPTM_A459_Selumetinib_30min_R1 1 SPTPPLFSLPEAR 13 0 A0A087WWS1;Q96FV9;J3KRD7;J3QQZ3;J3KT14;Q96FV9-2 A0A087WWS1 THOC1 THO complex subunit 1 1 S(0.959)PT(0.041)PPLFSLPEAR 77.89399999999998 0.042194 3369300.0 494.68 426.11 465.49 459.67 457.68 362.49 353.13 341.17 342.46 428.94 True False 506.2050815202794 376.22084310683533 402.2790147535439 379.3972635745639 416.28292480996697 358.84367971458624 326.49311979340615 332.12106332365687 581.1296077112202 483.99862722941816 1.0458812340398131 0.7773179962523002 0.8311573465741697 0.7838808670726403 0.8600911271028181 0.7414146642703022 0.6745744748541332 0.6862024903352247 1.2006844131724392 1.0 8.918859145348728 -8.262479895283324 24.999943294551613 1.1003422222346637 0.79566656765176 0.5493503935336586 0.10872864091235146 69.23342245736963 1663314.589720651 0.08786320317965911 0.02760831048892745 5.4641184424202875e-09 8.262479895283324 -0.3046756545829037 S(ph)PTPPLFSLPEAR ddPTM_A459_Selumetinib_30min_R2 2 SPTPPLFSLPEAR 13 0 A0A087WWS1;Q96FV9;J3KRD7;J3QQZ3;J3KT14;Q96FV9-2 A0A087WWS1 THOC1 THO complex subunit 1 1 S(0.997)PT(0.003)PPLFSLPEAR;S(0.996)PT(0.004)PPLFSLPEAR 99.844 0.011412 2437600.0 3601.6899999999996 4283.75 4432.5 4157.2 5945.9 3388.2 2637.42 2906.4700000000003 3157.36 6539.5 True False 3401.522488507429 4612.299850572767 4147.317775741103 3590.9821884299963 5198.922884979572 3854.893794982716 2760.065255948585 2914.9273465079877 3788.9202240093537 6350.68764333848 0.5356148309506984 0.7262677854123112 0.6530501905713172 0.5654477735488594 0.8186393626890082 0.6070041563178259 0.43460888189702435 0.4589939720253106 0.5966157425461984 1.0 12.632697097952086 -10.34294099739224 4.325337983832252 1.0000030241050057 0.6015511831303728 0.5475048391527471 0.1091929938270298 237259759.53379485 564732077.6437521 12232.521867605574 0.029632126287762454 4.540032926782237e-11 10.34294099739224 -0.39845184097463293 S(ph)PTPPPSSKPSSIPR ddPTM_A459_Selumetinib_30min_R2 1 SPTPPPSSKPSSIPR 15 1 H7C5F9;B4E2D5;R4GND2;F6S7C4;Q8NEM7-2;Q8NEM7;Q8NEM7-3 H7C5F9 SUPT20H Transcription factor SPT20 homolog 1 S(0.5)PT(0.5)PPPS(0.001)SKPSSIPR 64.842 0.037252 8909900.0 48447.0 48203.0 47667.0 59258.0 55084.0 33494.0 39550.0 44380.0 41017.0 56017.0 True False 45754.509688707105 51900.01510292596 44600.15711590549 51186.958174248226 48163.85546279197 38107.49447174049 41389.153366838254 44509.13845249547 49221.546110735435 54399.643660354996 0.8410810551329359 0.9540506446506248 0.8198611997234255 0.9409428946600235 0.8853707896232508 0.700510001676945 0.7608350088697651 0.8181880515686638 0.9048137597748049 1.0 15.731309580820607 -4.443270437391862 16.31926675115525 0.8551337850979228 0.5615394427801179 0.0 0.08770761727932819 13088502.213287916 42175613.13726748 0.022620067097512117 135330112.72768885 3.603541787539012e-05 4.443270437391862 -0.2935943423178049 S(ph)PTPPPTLHLVPEPAAPPPPPPR ddPTM_A459_Selumetinib_30min_R1 2 SPTPPPTLHLVPEPAAPPPPPPR 23 0 A0A087WWH3;Q9NZM4-2;Q9NZM4 A0A087WWH3 GLTSCR1 Glioma tumor suppressor candidate region gene 1 protein 1 S(0.499)PT(0.499)PPPT(0.003)LHLVPEPAAPPPPPPR;S(0.499)PT(0.499)PPPT(0.002)LHLVPEPAAPPPPPPR 103.45 1.9142e-05 12478000.0 3390.0 4422.7 3335.9 3810.2 3409.5 3056.6000000000004 3236.3999999999996 3059.8999999999996 1957.77 3085.8 True False 3468.9804042082674 3904.8882279425525 2882.9031027870546 3144.8200963121444 3101.111326996117 3025.8533791707496 2992.2757423594094 2978.741512044017 3322.192700136645 3481.892488237369 0.9962916476965553 1.1214844344373527 0.8279701663753727 0.9031927628254082 0.8906395982852376 0.8690255053516948 0.85938200345588 0.8554949706537145 0.9541341989621372 1.0 11.76565594167712 -5.26200942554395 24.999997320026512 0.8877590152778149 1.0588880454643486 0.5797360871223839 0.05555061234681952 29.06457668332218 1274729.4959635865 0.013330592871604534 0.03074577215371479 5.4700409107136e-06 5.26200942554395 0.1711290301865337 S(ph)PTPPPTLHLVPEPAAPPPPPPR ddPTM_A459_Selumetinib_30min_R2 1 SPTPPPTLHLVPEPAAPPPPPPR 23 0 A0A087WWH3;Q9NZM4-2;Q9NZM4 A0A087WWH3 GLTSCR1 Glioma tumor suppressor candidate region gene 1 protein 1 S(0.496)PT(0.496)PPPT(0.008)LHLVPEPAAPPPPPPR 86.258 0.00017076 9356900.0 32456.0 27845.0 31538.0 27672.0 36660.0 29878.0 28301.0 29202.0 23378.0 27677.0 True False 30652.225451662205 29980.621964213293 29508.87941597808 23903.025863137413 32054.443055441738 33993.42329452028 29617.05257736763 29286.972985348664 28054.253235896656 26877.893096517935 1.140425156897184 1.1154379495652254 1.0978866278696895 0.8893191805362929 1.1925950795449227 1.2647354155495236 1.1019112424851691 1.0896305331738532 1.043766828566303 1.0 14.714132432162518 -8.355768034392614 1.9826733290183278 1.0022647353260103 1.1132439037740425 0.1501918761681026 0.0897728012086201 0.681650167748848 5.298743180459995 0.09157118736880528 0.026206174665247214 4.407902357653863e-09 8.355768034392614 0.11097916844803213 S(ph)PTPVKPTEPCTPSK ddPTM_A459_Selumetinib_30min_R2 1 SPTPVKPTEPCTPSK 15 1 A0A075B6Q3;Q5H9F3-3 A0A075B6Q3 BCORL1 1 S(0.992)PT(0.008)PVKPTEPCTPSK 78.234 0.01835 7507700.0 16650.0 11163.0 14176.0 16213.0 16848.0 10653.0 13793.0 15190.0 14987.0 11915.0 True False 15724.65965523094 12019.16620529766 13263.931593661782 14004.761431015002 14731.40361696897 12120.354051694385 14434.401830310991 15234.20038516013 17984.81877176761 11570.982991112169 1.3589735346866612 1.0387333742111406 1.1463098341644777 1.210334631186672 1.2731332876631454 1.04747833965396 1.2474654782051149 1.3165865334744444 1.554303449031253 1.0 13.498223810646767 -7.575608573812973 4.3870164513900205 1.323583091139419 1.1748081786019788 0.08345181407893953 0.15452462202673198 0.38860103642657434 15.785441085651774 0.07212807087729652 0.04076888665269592 2.656999215534296e-08 7.575608573812973 -0.14877491253744024 S(ph)PTQHCLAR ddPTM_A459_Selumetinib_30min_R2 2 SPTQHCLAR 9 0 O75161-2;O75161 O75161-2 NPHP4 Nephrocystin-4 1 S(0.999)PT(0.001)QHCLAR;S(0.997)PT(0.003)QHCLAR 98.182 0.013182 15723300.0 20675.6 15471.2 19999.5 21107.0 26749.0 17644.9 22206.0 22692.4 21255.0 24473.0 True False 19526.532922984567 16657.79129225129 18712.75394380918 18232.190188394114 23388.551480905935 20075.324810545597 23238.62300035423 22758.43112707095 25506.593914320452 23766.4009015097 0.8216024379923758 0.7008966717881607 0.7873617053485158 0.7671414053793884 0.9841015296270726 0.8446935189614833 0.9777931078692716 0.9575884552896388 1.0732207211357867 1.0 14.536635822809473 -6.615381181296305 0.6738819452561947 1.021355366209986 0.7396806092497077 0.7317798051551481 0.06015219388092724 0.3810126512190884 0.38435117977914035 0.04218908622295822 0.051487501069740295 2.424481188059478e-07 6.615381181296305 -0.2816747569602782 S(ph)PTQSQPAFLATNEEK ddPTM_A459_Selumetinib_30min_R2 2 SPTQSQPAFLATNEEK 16 0 J3QT39;Q49A88;A0A0A0MR27;Q49A88-2;Q49A88-3;Q49A88-6;C9JSI8;Q49A88-4 J3QT39 CCDC14 Coiled-coil domain-containing protein 14 1 S(0.937)PT(0.063)QSQPAFLATNEEK;S(0.959)PT(0.041)QSQPAFLATNEEK 218.36 1.1213e-10 5415300.0 13218.4 10956.0 13312.0 14664.9 13185.3 10252.6 12547.0 12543.1 13071.9 11155.099999999999 True False 12483.774245447721 11796.28997090756 12455.520413009717 12667.515321636456 11528.844735922423 11664.802586163689 13130.46036140883 12579.598344378011 15686.645259402747 10833.023278569479 1.1523813735491415 1.0889194703609353 1.1497732528323794 1.1693425737112628 1.0642315113205247 1.0767818259229336 1.212077185081313 1.1612269281525232 1.4480394674711894 1.0 13.403148305812016 -7.327008627133873 7.297647030662394 1.2194639712691586 1.1171966324779912 0.13609623066785115 0.10682092114824815 0.5011645784315261 48.94116111200185 0.04276695544781878 0.028762083833466012 4.709679706619423e-08 7.327008627133873 -0.10226733879116745 S(ph)PTSAPTQR ddPTM_A459_Selumetinib_30min_R2 1 SPTSAPTQR 9 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5;F8VV64;Q63HR2-2;H0YID7 Q63HR2-6 TNS2 Tensin-2 1 S(0.966)PT(0.026)S(0.008)APTQR 86.189 0.034176 13084000.0 1043.6 2671.8 3105.2 3744.7 3365.8 2414.6 2606.1 2398.0 2463.7 3239.7 True False 985.6008898618026 2876.718468808946 2905.414812686129 3234.66540003219 2942.9581133662236 2747.1892324435617 2727.288813889182 2404.977782989729 2956.5088415295822 3146.161443248516 0.3132709200212361 0.9143581855858733 0.92347925085694 1.0281307740814123 0.9354123004976889 0.8731876230760102 0.8668623219389422 0.7644165203761792 0.9397193675086453 1.0 11.61937698828219 -4.761200582713965 24.999999999938257 0.9102559086070133 0.313270258165469 0.871552153778065 0.06940266877807322 2.009480061357855 209948.06520938055 0.018470779925189192 0.10426151018647127 1.7330034100708153e-05 4.761200582713965 -0.5969856504415443 S(ph)PTSSVATPSSTISTPTKR ddPTM_A459_Selumetinib_30min_R1 1 SPTSSVATPSSTISTPTKR 19 1 A0A2R8YE27;A0A2R8YE71;A0A2R8Y7K8;A0A2R8Y5S6;A0A2R8Y622;A0A2R8YGJ7;A0A2U3TZH5;A0A2R8Y700;A0A2R8Y7A1;A0A2R8YED7;Q8WXI2-4;Q8WXI2-2;Q8WXI2-5;Q8WXI2 A0A2R8YE27 CNKSR2 Connector enhancer of kinase suppressor of ras 2 1 S(0.384)PT(0.329)S(0.049)S(0.235)VAT(0.002)PSSTISTPTKR 132.5 0.0011192 0.0 513.28 427.07 539.99 669.65 451.97 525.79 326.57 654.84 250.48 315.27 True False 525.2384253309797 377.0684458605436 466.66232395275114 552.7081983873355 411.0893933017847 520.5010299791231 301.93656197698476 637.4715159799031 425.04626566462184 355.7379754898552 1.4764755565039702 1.059961184468192 1.3118147516023608 1.5536946754876257 1.155596033107542 1.4631584644917015 0.8487611185204916 1.7919692579969781 1.1948296076046656 1.0 8.474671181960518 S(ph)PTSSVATPSSTISTPTKR ddPTM_A459_Selumetinib_30min_R2 1 SPTSSVATPSSTISTPTKR 19 1 A0A2R8YE27;A0A2R8YE71;A0A2R8Y7K8;A0A2R8Y5S6;A0A2R8Y622;A0A2R8YGJ7;A0A2U3TZH5;A0A2R8Y700;A0A2R8Y7A1;A0A2R8YED7;Q8WXI2-4;Q8WXI2-2;Q8WXI2-5;Q8WXI2 A0A2R8YE27 CNKSR2 Connector enhancer of kinase suppressor of ras 2 1 S(0.999)PT(0.001)SSVATPSSTISTPTKR 229.02 2.5367e-23 3861300.0 8982.4 10551.0 9852.8 9783.2 10373.0 7024.6 8160.6 7545.6 6154.3 10008.0 True False 8483.19416739618 11360.227773187808 9218.88157491753 8450.711283038672 9069.851004203416 7992.174887030161 8540.084069922132 7567.5564467586755 7385.3319655094065 9719.04303609321 0.8728425356171889 1.1688627914291354 0.948537992956894 0.8695003460377337 0.9332041200477335 0.8223211747648355 0.8786959825372903 0.7786318486969708 0.7598826281643989 1.0 13.246598553734954 -5.6174239590023145 3.596745945931826 0.8555108211652628 1.0285695469314273 0.30927038138921303 0.09408673483593823 0.23398856581701274 5.854855203219609 0.025332122052918387 0.04741221678017932 2.4131040080794444e-06 5.6174239590023145 0.17305872576616455 S(ph)PTVLCQK ddPTM_A459_Selumetinib_30min_R2 1 SPTVLCQK 8 0 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 S(0.998)PT(0.002)VLCQK 93.667 0.023742 7842300.0 52284.0 46015.0 49955.0 57156.0 52503.0 50412.0 53861.0 59055.0 54344.0 48415.0 True False 49378.2645894351 49544.20253845487 46740.94968689156 49371.254200400515 45907.10375722471 57355.79540542731 56365.6432235468 59226.840272918475 65214.318498227716 47017.13315272306 1.0502185326579252 1.053747840761011 0.9941258973631083 1.0500694297976592 0.9763909596126862 1.2198913791515482 1.1988319883404528 1.2596863377555438 1.3870330691238826 1.0 15.520898953579904 -6.771937750187269 24.567531760876214 1.2284279886070817 1.0262000685542745 0.5077508759669607 0.09201957299898583 129.9792291640735 304166.0197047512 0.030951937638899304 0.027592312692111647 1.6906832491898678e-07 6.771937750187269 -0.2022279200528072 S(ph)PTVPSQNPSR ddPTM_A459_Selumetinib_30min_R2 1 SPTVPSQNPSR 11 0 Q03164-2;Q03164;Q03164-3 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 S(0.997)PT(0.002)VPSQNPSR 93.623 0.023338 3671500.0 4876.9 5444.6 5461.8 9567.6 5250.4 4426.0 4093.6 5470.4 1982.8 6948.3 True False 4605.861421777525 5862.183312851708 5110.393734358208 8264.47637496941 4590.797812828458 5035.641324772298 4283.9605113145135 5486.317958326525 2379.4154040609064 6747.6845251485265 0.6825839893094503 0.868769618823084 0.7573551661035488 1.224787013110619 0.6803515777476878 0.7462769348514342 0.6348786009998322 0.8130667546591862 0.3526269485766352 1.0 12.720176809466725 S(ph)PVAPAR ddPTM_A459_Selumetinib_30min_R2 1 SPVAPAR 7 0 O15525 O15525 MAFG Transcription factor MafG 1 S(1)PVAPAR 89.355 0.031073000000000007 4229200.0 9481.4 7189.2 7367.9 8295.0 12321.0 8652.9 10033.0 10401.0 9343.4 9210.8 True False 8954.461745051449 7740.5885230785525 6893.857335562971 7165.206690326862 10773.12582886246 9844.75843179445 10499.554380012347 10431.265188021755 11212.341076408453 8944.860271467558 1.0010734067713185 0.8653671816170893 0.7707059838098416 0.8010417684424361 1.204392858234659 1.1006050550836886 1.1738086522719615 1.1661741907020675 1.2534953857438933 1.0 13.126843230635714 -6.262010478098023 24.99999112252444 1.1568008224697452 0.8536170054782192 0.7389248185500978 0.08441344477424159 25.47716841062262 1115270.892456172 0.025648216792958478 0.030875179631533176 5.470027653564132e-07 6.262010478098023 -0.3031838169915261 S(ph)PVCSCESASPCPK ddPTM_A459_Selumetinib_30min_R2 2 SPVCSCESASPCPK 14 0 Q5VYV7 Q5VYV7 SLX4IP Protein SLX4IP 1 S(1)PVCSCESASPCPK;S(1)PVCSCESASPCPK 104.55 0.006123699999999999 7646500.0 25528.0 21283.0 23533.0 27597.0 30409.0 20842.0 25929.0 28333.0 21735.0 25372.0 True False 24109.255956680805 22915.337664368897 22018.91240079309 23838.24099251965 26588.749560090782 23712.796315161377 27134.74987733877 28415.444339219346 26082.607326641017 24639.444435627167 0.9784821252633545 0.9300265565742499 0.8936448408290837 0.9674828933257512 1.079113193057431 0.9623916796140942 1.101272796480084 1.1532502047056024 1.0585712431456904 1.0 14.588682106402002 -6.406153039108242 1.1705331537964694 1.0794949801217373 0.930882108538985 0.502578731982371 0.05509789172906783 0.3717674807848894 1.0618316792152815 0.024844160752247407 0.03164740992331 3.92506597366108e-07 6.406153039108242 -0.14861287158275227 S(ph)PVDSGTILR ddPTM_A459_Selumetinib_30min_R1 1 SPVDSGTILR 10 0 P49454 P49454 CENPF Centromere protein F 1 S(1)PVDSGTILR 98.898 0.01907 3663200.0 1056.9 1202.7 879.89 980.9 994.58 996.8 1123.3 1086.0 544.15 949.41 True False 1081.523713630596 1061.8873248799396 760.4057708898052 809.6042287734454 904.6204146073605 986.7730970219852 1038.5685766259817 1057.1957521748438 923.3828068564511 1071.276021536536 1.0095658746093854 0.9912359686319402 0.7098131159504082 0.755738215452845 0.8444326171978155 0.9211193727706629 0.9694687043740212 0.9868565438984653 0.861946676947029 1.0 10.065114532813885 -6.905481834540123 4.067590547090142 0.9526747531624025 0.8552386446160927 0.1812425777459009 0.09245942062395458 0.42269287681447976 13.0601425891691 0.03746214724156908 0.03267420931464013 1.2431346319922815e-07 6.905481834540123 -0.0974361085463098 S(ph)PVDSGTILR ddPTM_A459_Selumetinib_30min_R2 1 SPVDSGTILR 10 0 P49454 P49454 CENPF Centromere protein F 1 S(1)PVDSGTILR 115.91 0.0064985 11911000.0 24398.0 23985.0 22411.0 20729.0 22287.0 24390.0 22160.0 26963.0 24992.0 23932.0 True False 23042.05683293241 25824.572376069533 20969.100659251846 17905.674440480463 19487.10781169204 27749.501109624136 23190.483909206963 27041.457866035056 29991.098334824594 23241.020977196513 0.9914390962230393 1.1111634209791357 0.9022452447259603 0.770434072498323 0.8384789906954727 1.1939880410955794 0.9978255228959547 1.1635228027446571 1.2904380734500038 1.0 14.50438582722409 -6.765189901581 24.999854342174707 1.1311669905014312 0.9236180626338392 0.4386085484153879 0.11674296600289956 102.81453155528686 685325.7084720978 0.0436842502157624 0.03999568644430387 1.7171573709288664e-07 6.765189901581 -0.20754892786759205 S(ph)PVEGLGR ddPTM_A459_Selumetinib_30min_R2 2 SPVEGLGR 8 0 Q9Y5U2-2;Q9Y5U2;A6NCC9;E9PME3;C9JHT9;C9JJV1 Q9Y5U2-2 TSSC4 Protein TSSC4 1 S(1)PVEGLGR;S(1)PVEGLGR 104.42 0.014616999999999996 50594000.0 24176.2 25209.7 29628.5 33657.0 42275.0 25073.7 23792.3 33935.0 39013.0 29177.6 True False 22832.583588996662 27143.202928038365 27722.234567071675 29072.85853843657 36964.03655670482 28527.37457861349 24898.68909354806 34033.74523175832 46816.69011429707 28335.16687549092 0.8058037451950273 0.9579334064736507 0.9783684948420257 1.026034491562629 1.304528634651438 1.00678336231324 0.8787203972701741 1.2011132802325757 1.652246846472329 1.0 14.790306078546536 -3.8703993058222537 0.35294068249469723 1.2150678142030624 0.17627103157236831 0.27124135962695206 0.19986428658336994 18.240421109047418 1.1026330628571908 0.18803943851488644 9.13895367398217 0.00013477231680548293 3.8703993058222537 -1.038796782630694 S(ph)PVFTPR ddPTM_A459_Selumetinib_30min_R2 2 SPVFTPR 7 0 P52735-3 P52735-3 VAV2 Guanine nucleotide exchange factor VAV2 1 S(1)PVFTPR;S(1)PVFTPR 96.034 0.023406 12863200.0 21130.0 13079.900000000001 21758.3 21116.0 19661.6 15227.8 20928.2 24879.0 20980.7 17837.3 True False 19955.679190091876 14083.086271492675 20358.39466664581 18239.964372868228 17191.534031065832 17325.291225794757 21901.40276844158 24951.39377105983 25177.426249738088 17322.290802128835 1.1520231023739314 0.8130036859652492 1.1752714983946495 1.0529764556675503 0.9924515312347179 1.0001732117131732 1.2643479444271881 1.4404211345992073 1.4534697827982366 1.0 14.080342112750902 -7.357087698639501 4.163604991682328 1.3372451844041724 1.0268409297817263 0.40846102423981534 0.1500223081653108 0.19832696202268804 6.0854156914432895 0.06290256280268622 0.041308869288876275 4.394528661868929e-08 7.357087698639501 -0.31040425462244614 S(ph)PVGKS(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 3 SPVGKSPPSTGSTYGSSQK 19 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 2 S(1)PVGKS(0.996)PPS(0.003)T(0.001)GSTYGSSQK;S(1)PVGKS(0.999)PPS(0.001)TGSTYGSSQK;S(1)PVGKS(0.99)PPS(0.005)T(0.002)GS(0.001)TYGS(0.001)SQK 121.56 0.0008433 38662000.0 73303.0 51207.0 55989.0 68566.0 63335.0 70135.0 92161.0 93511.0 79040.0 53670.0 True False 69229.11271515883 55134.41224354358 52386.728696214006 59227.19251705261 55378.29107791605 79795.45962785927 96446.669113557 93783.10152842049 94850.20856212126 52120.407648593326 1.328253477638087 1.0578277248956167 1.005109726873517 1.1363532095983344 1.062506867776017 1.530983030022653 1.8504588406871372 1.7993547203376794 1.8198286015263192 1.0 15.669560747229559 -6.866402112658507 4.1063657762558385 1.6848307421476454 1.1091001296222038 0.4867238695861815 0.24407497201244624 0.16182311655983148 4.979544045962683 0.08416216412192612 0.07431883899674113 1.3601847061177196e-07 6.866402112658507 -0.5757306125254416 S(ph)PVGKSPPS(ph)TGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 1 SPVGKSPPSTGSTYGSSQK 19 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 2 S(0.999)PVGKS(0.224)PPS(0.552)T(0.162)GS(0.032)T(0.011)Y(0.009)GS(0.009)S(0.003)QK 68.192 0.038621 9035600.0 25825.0 17086.0 21199.0 26306.0 23295.0 24843.0 34836.0 33017.0 32451.0 22824.0 True False 24389.749885665995 18396.441259850908 19835.079419726033 22723.07741961887 20368.473840057693 28264.897747699564 36455.94302622443 33113.07400374141 38942.106756697845 22165.01181612623 1.1003716166720539 0.8299766051316299 0.8948824202879493 1.0251777715311938 0.9189471230165798 1.275203369263956 1.6447517975018981 1.4939344169286604 1.756917933531864 1.0 14.435996511150853 -6.93912585021519 3.373222226013298 1.513167061235784 0.9474915252866096 0.6048011121505039 0.19771469678092662 0.1456038616538559 3.3752542595013275 0.07073161071042836 0.060053717031891295 1.150466957366574e-07 6.93912585021519 -0.5656755359491743 S(ph)PVGKSPPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 1 SPVGKSPPSTGSTYGSSQK 19 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.992)PVGKS(0.008)PPSTGSTYGSSQK 87.24 0.0018694 56049000.0 107280.0 85183.0 103020.0 105290.0 102750.0 76869.0 94803.0 72897.0 65847.0 88178.0 True False 101317.80707586637 91716.26219348471 96391.80535969528 90949.32036461901 89841.6264033452 87457.00700269364 99211.52734858058 73109.11820125206 79018.23991890172 85632.07202604169 1.18317593722425 1.0710503672688518 1.1256507413528594 1.062094122129385 1.0491586187009856 1.0213113490480177 1.1585790814265153 0.8537586031903881 0.9227645442804581 1.0 16.385863614108032 -7.762649046062969 24.999999976879703 0.9161961668813253 1.0900894589087624 0.6459159236629209 0.05756495325326863 19.20815695753714 396939.0247151481 0.028789520984843373 0.015037161201471746 1.727233107502567e-08 7.762649046062969 0.17389329202743709 S(ph)PVGLSSDGISSSSSSSR ddPTM_A459_Selumetinib_30min_R1 2 SPVGLSSDGISSSSSSSR 18 0 O60583-2;O60583 O60583-2 CCNT2 Cyclin-T2 1 S(0.998)PVGLS(0.002)S(0.001)DGISSSSSSSR;S(1)PVGLSSDGISSSSSSSR 194.05 2.6079000000000004e-10 17653000.0 786.22 717.52 795.8199999999999 680.57 975.29 683.17 919.33 563.78 373.7 805.1400000000001 True False 804.5373962821903 633.5124248340018 687.7520151263509 561.7212253811234 887.0751917014344 676.2979300687298 849.9841979431706 548.8267229844691 634.1416060318951 908.4875617277323 0.8855788787599327 0.6973264704133189 0.7570296436622713 0.6183037050203088 0.9764307504820687 0.7444217824871132 0.9356035610731952 0.6041103324967138 0.698019029369984 1.0 9.827322952163055 -4.730481159061139 22.706683213486244 0.7728011355214162 0.8855810554075804 0.04732794328918388 0.13574164650426288 3762.263370399233 2758995.987159066 0.03245618049091125 3.3053675119740893 1.860025254696697e-05 4.730481159061139 0.1127799198861642 S(ph)PVGLSSDGISSSSSSSR ddPTM_A459_Selumetinib_30min_R2 2 SPVGLSSDGISSSSSSSR 18 0 O60583-2;O60583 O60583-2 CCNT2 Cyclin-T2 1 S(1)PVGLSSDGISSSSSSSR;S(1)PVGLSSDGISSSSSSSR 154.39 4.5722e-05 33379000.0 0.0 0.0 1343.9 0.0 1108.0 2455.1000000000004 2820.7 2347.3 0.0 1169.0 True False 0.0 0.0 1257.434937127685 0.0 968.8031343543224 2793.267739821164 2951.8681391110135 2354.130254383565 0.0 1135.2479325732365 0.0 0.0 1.107630237456139 0.0 0.8533846277600012 2.46049136904371 2.600196885996605 2.0736705937420385 0.0 1.0 10.148791694100789 -6.558440980011035 6.428135220532602 1.751640489641935 0.32764311950422104 0.4034543852971707 0.767661261291657 0.181127407458743 21.483064194705467 0.2610604335675853 0.2636958333123802 2.764133535377501e-07 6.558440980011035 -1.423997370137714 S(ph)PVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK ddPTM_A459_Selumetinib_30min_R1 2 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK 51 0 P16989-2;P16989;P16989-3 P16989-2 YBX3 Y-box-binding protein 3 1 S(0.727)PVGS(0.273)GAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK;S(0.716)PVGS(0.284)GAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK 70.658 3.4106000000000004e-11 23730000.0 4061.5 5906.0 3031.1400000000003 2386.51 3630.43 3438.6 4799.2 4155.5 2743.46 5129.0 True False 4156.125047696722 5214.522774375092 2619.5278368602035 1969.750828840979 3302.0582475044744 3404.010805998999 4437.1924801419145 4045.282641033668 4655.4512456094835 5787.357110690734 0.7181386889050431 0.9010197011590195 0.4526293758546994 0.3403541186705662 0.5705641079940834 0.5881805357597369 0.7667044551208497 0.6989861803345421 0.8044174839340171 1.0 12.498688953468186 -8.365052605380797 0.8491767224135109 0.9921807304181116 0.5955688045665279 0.41948164664756127 0.14523631762353956 0.6540173576090723 1.0417659475983971 0.1553973590940872 0.05704548433265707 4.3146681079276305e-09 8.365052605380797 -0.39661192585158367 S(ph)PVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK ddPTM_A459_Selumetinib_30min_R2 1 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK 51 0 P16989-2;P16989;P16989-3 P16989-2 YBX3 Y-box-binding protein 3 1 S(0.586)PVGS(0.414)GAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK 62.264 2.0572e-07 17811000.0 20617.0 12047.0 17912.0 17112.0 19589.0 14603.0 19370.0 18733.0 19332.0 16293.0 True False 19471.189676390175 12970.966162789653 16759.561421111033 14781.316080153505 17128.054692118072 16614.43069716447 20270.74338092685 18787.509928584896 23198.94018121114 15822.5787557021 1.2305952131458469 0.819775737132306 1.0592180756295029 0.9341913419028901 1.082507153642418 1.0500456944274652 1.2811276653384793 1.187386090387719 1.4661921131440578 1.0 13.94969712821449 -7.167358299267996 3.450037396935335 1.2504131805279692 1.01385202221374 0.3151399568213368 0.14590592745471953 0.26573632038289163 5.975124988300094 0.056409934397490376 0.041949123135302795 6.80207945684161e-08 7.167358299267996 -0.2365611583142293 S(ph)PVIGSEVFLPNSNHVASGAGEAEER ddPTM_A459_Selumetinib_30min_R1 1 SPVIGSEVFLPNSNHVASGAGEAEER 26 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-12;P29590-13;P29590-11;H3BVD2 P29590-2 PML Protein PML 1 S(0.991)PVIGS(0.009)EVFLPNSNHVASGAGEAEER 104.83 2.4697e-08 12182000.0 687.02 655.29 354.27 371.25 778.87 380.22 732.37 636.8 233.25 367.49 True False 703.0262292917889 578.5683421639441 306.16207986581435 306.41815672560057 708.4213460206668 376.3953320121385 677.1267412655305 619.9099953820813 395.8082140940318 414.66092115572974 1.695424365846525 1.395280607951617 0.738343220317191 0.7389607775711335 1.7084352777835377 0.9077183616991479 1.6329649280145917 1.494980509989434 0.9545346424033587 1.0 8.695788279672561 -6.259542747996213 24.986919747510935 1.3065782305071165 1.1312608052227313 0.030980127808504676 0.371052217029872 649.4984833442534 8556704.6631583 0.1152699691906954 0.1413696392766114 5.501197690623347e-07 6.259542747996213 -0.1753174252843852 S(ph)PVIGSEVFLPNSNHVASGAGEAEER ddPTM_A459_Selumetinib_30min_R2 4 SPVIGSEVFLPNSNHVASGAGEAEER 26 0 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-12;P29590-13;P29590-11;H3BVD2 P29590-2 PML Protein PML 1 S(0.999)PVIGS(0.001)EVFLPNSNHVASGAGEAEER;S(0.99)PVIGS(0.01)EVFLPNSNHVASGAGEAEER;S(0.998)PVIGS(0.002)EVFLPNSNHVASGAGEAEER;S(1)PVIGSEVFLPNSNHVASGAGEAEER 143.01 6.786200000000001e-10 51927000.0 22812.2 14472.0 26188.3 33280.7 38454.9 25327.2 25586.300000000003 29555.800000000003 33177.0 28071.1 True False 21544.389248472027 15581.955865185666 24503.373289665127 28747.81124759027 33623.85167083216 28815.79190256959 26776.113648291604 29641.8024847739 39813.32704283273 27260.614405523178 0.7903119470450011 0.5715922478265443 0.8988562372497585 1.0545547807523288 1.2334223715816086 1.0570485123303501 0.9822270785968268 1.0873490246341726 1.4604706427587446 1.0 14.734530457826555 -5.601408674603181 2.52429314067375 1.12850760876079 0.6818776935531307 0.6201640221279587 0.14007740877410052 0.18072999168331486 2.3123931014923156 0.04031574498318833 0.08501565686344317 2.503752093280002e-06 5.601408674603181 -0.44662991520765927 S(ph)PVLEEAPFSR ddPTM_A459_Selumetinib_30min_R1 2 SPVLEEAPFSR 11 0 Q9BZL4-3;K7EL81 Q9BZL4-3 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 S(1)PVLEEAPFSR;S(1)PVLEEAPFSR 142.12 0.00094801 13986400.0 1192.96 1401.03 1032.97 1147.9299999999998 1444.3400000000001 933.22 1373.5700000000002 1453.4099999999999 621.53 811.28 True False 1220.7536469039228 1236.996756278823 892.698347698056 947.4655748148646 1313.6997020189388 923.8326540959646 1269.9605090324487 1414.8608454589673 1054.6910152448602 915.4156905363973 1.3335511500667085 1.351295120967385 0.9751835771735244 1.0350112900726962 1.4350854104862052 1.009194690069858 1.3873047208621716 1.5455938324914609 1.1521443494450625 1.0 9.838283210209092 -7.31137350516432 24.99979579891874 1.3167268601853692 1.1915693747850602 0.018924242835143268 0.19857736405899173 1040.5367718652637 520946.79534563713 0.08271590379196365 0.055767183754731 4.882322855766031e-08 7.31137350516432 -0.12515748540030902 S(ph)PVLEEAPFSR ddPTM_A459_Selumetinib_30min_R2 2 SPVLEEAPFSR 11 0 Q9BZL4-3;K7EL81 Q9BZL4-3 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 S(1)PVLEEAPFSR;S(1)PVLEEAPFSR 114.72 0.0063849 26045000.0 5998.5 6077.0 5044.3 9831.3 5500.7 8474.5 5664.4 6098.9 11541.5 7192.9 True False 5665.127383898064 6543.086359365209 4719.755229818575 8492.259980061537 4809.65288911807 9641.785451148407 5927.805823795662 6116.646789272749 13850.122496453985 6985.222287601398 0.8110160494038291 0.93670410045204 0.6756771703881245 1.215746561871781 0.6885468623747433 1.3803119004906035 0.8486209285447329 0.8756552815977882 1.982774767388236 1.0 12.770090311265687 -8.225385864990809 24.977511248089122 1.4913878566334393 0.9347480691047969 0.3561206092405904 0.30238495705670926 503.44600898009696 348783.32707080856 0.18733727846566947 0.07080161034120087 5.951331405134853e-09 8.225385864990809 -0.5566397875286424 S(ph)PVPAQIAITVPK ddPTM_A459_Selumetinib_30min_R1 2 SPVPAQIAITVPK 13 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 S(1)PVPAQIAITVPK;S(1)PVPAQIAITVPK 209.66 8.1262e-06 169406000.0 8308.7 8536.599999999999 10141.0 8216.5 8951.8 7283.1 9222.0 9085.6 5017.2 6975.1 True False 8502.276544084143 7537.130903442323 8763.90790052566 6781.642517807131 8142.1112705686555 7209.838626525705 8526.377115325206 8844.62037381193 8513.821958210401 7870.422028227525 1.0802821644875524 0.9576526997421686 1.1135245186463472 0.8616618643173835 1.0345202889205571 0.9160676010342754 1.08334433461701 1.123779683235589 1.081749101595226 1.0 12.942225282746382 -7.309439910710899 23.543205910466433 1.0825333901803538 0.9935675766276455 0.20085790999261333 0.07536295235185184 295.2007405355887 144787.7443720673 0.02987965843532107 0.02014494519027611 4.9041087169012494e-08 7.309439910710899 -0.08896581355270827 S(ph)PVPAQIAITVPK ddPTM_A459_Selumetinib_30min_R2 4 SPVPAQIAITVPK 13 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 S(1)PVPAQIAITVPK;S(1)PVPAQIAITVPK;S(1)PVPAQIAITVPK;S(1)PVPAQIAITVPK 160.63 0.00036391 126035000.0 183760.0 146841.0 169505.0 185542.0 183066.0 140708.0 143540.0 181014.0 136796.0 168547.0 True False 173547.35484956365 158103.23253176676 158599.23284308953 160270.85952219702 160067.61244919535 160089.24977995048 150214.8944191139 181540.72077151932 164159.02239959445 163680.61017230246 1.0602804734591025 0.9659252391919572 0.9689555328278414 0.9791682677226332 0.9779265380346286 0.9780587304227945 0.917731759803354 1.1091156159572961 1.002922839955132 1.0 17.32052390275411 -7.757457874158488 24.99986414564929 1.042014413226309 0.9774682355564747 0.2823970374585726 0.04293183019266298 114.32199620325713 717840.532428832 0.02010137940854088 0.01104199943900393 1.7480028075566622e-08 7.757457874158488 -0.06454617766983428 S(ph)PVPPSCPAPQPRPPPPPPPGER ddPTM_A459_Selumetinib_30min_R1 1 SPVPPSCPAPQPRPPPPPPPGER 23 1 A7MCY6 A7MCY6 TBKBP1 TANK-binding kinase 1-binding protein 1 1 S(0.948)PVPPS(0.052)CPAPQPRPPPPPPPGER 62.871 0.0037415 7220800.0 588.54 540.24 635.8 745.92 520.56 476.08 546.65 461.81 443.29 523.99 True False 602.2518369005119 476.9884496492376 549.4618521994091 615.6590746525522 473.4754399123327 471.2910674460541 505.4157503895603 449.56129862970954 752.2307533793921 591.249220594821 1.0186091007352562 0.8067468556987992 0.9293235966495277 1.0412852198488716 0.8008051823493263 0.7971106785932266 0.8548269203316518 0.7603583784473025 1.2722735644752596 1.0 9.207622566417493 -8.258602910670174 24.99969745720227 1.1361367838704344 0.8752432080583717 0.4780944317020934 0.10865896804196483 197.66467342541645 1742192.210134028 0.07967771279814428 0.027150014180128537 5.51311547800963e-09 8.258602910670174 -0.26089357581206263 S(ph)PVPSAFSDQSR ddPTM_A459_Selumetinib_30min_R1 4 SPVPSAFSDQSR 12 0 Q9UQ35;Q9UQ35-2;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(1)PVPSAFSDQSR;S(0.998)PVPS(0.002)AFSDQSR;S(1)PVPSAFSDQSR;S(1)PVPSAFSDQSR 198.37 0.00012738 985400000.0 3317.25 4538.15 2583.4 2817.0499999999997 3452.49 2873.7799999999997 4076.78 3560.69 2244.29 3318.96 True False 3394.5354707551282 4006.821288271304 2232.588469600431 2325.1051000777184 3140.212889086617 2844.8723823834694 3769.26520236559 3466.248934448846 3808.396213543815 3744.980845408095 0.9064226523127175 1.069917698827289 0.5961548434454391 0.6208590099809573 0.8385124033243018 0.7596493813504299 1.006484507654364 0.9255718727370753 1.0169334292359538 1.0 11.870742624359352 -7.2633865021278226 24.938438546622223 0.9810451156939318 0.7954541759443889 0.33872090976020464 0.1289789235221125 228.997928904551 2932934.2774979807 0.05704901009127388 0.040654882125132276 5.4527237774003515e-08 7.2633865021278226 -0.18559093974954288 S(ph)PVPSAFSDQSR ddPTM_A459_Selumetinib_30min_R2 6 SPVPSAFSDQSR 12 0 Q9UQ35;Q9UQ35-2;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.998)PVPS(0.002)AFSDQSR;S(0.998)PVPS(0.002)AFSDQSR;S(1)PVPSAFSDQSR;S(1)PVPSAFSDQSR;S(0.998)PVPS(0.002)AFSDQSR;S(1)PVPSAFSDQSR 131.08 0.0020759 1816355000.0 282733.6 135461.9 201502.6 215730.6 128742.9 223986.9 317359.1 296179.0 151140.4 137815.5 True False 267020.3983842767 145851.39215134043 188538.14209544292 186347.72012395735 112569.06592587101 254839.0623243654 332116.9269851268 297040.83185492735 181372.7032156179 133836.40842732866 1.9951252541961715 1.0897736562509128 1.4087208728245018 1.392354459550083 0.8410944917652544 1.9041086451654112 2.4815140430599776 2.2194321810138566 1.3551820864507194 1.0 17.030111109940613 -6.850756316039193 13.383327711115335 1.9120749577601566 1.3374108874677508 0.15587124235414251 0.48053245091190194 1.0478552987102525 152.59510867295975 0.16594507375820636 0.1463583000167867 1.4100797765622044e-07 6.850756316039193 -0.5746640702924057 S(ph)PVPTTLPGLR ddPTM_A459_Selumetinib_30min_R1 1 SPVPTTLPGLR 11 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(1)PVPTTLPGLR 100.09 0.016614 9226700.0 1071.7 1518.2 1360.1 1175.0 881.3 1143.0 1396.4 1390.5 728.0 1539.3 True False 1096.6685248348092 1340.448438207969 1175.405890494522 969.8083074816993 801.5865706061526 1131.5024577609645 1291.0684237519104 1353.6194230194474 1235.3628289837302 1736.884149051715 0.6313999269516947 0.771754661322583 0.6767324643593859 0.5583609638047446 0.4615083689051996 0.6514553422453246 0.7433244321198934 0.7793377720433926 0.7112522902913243 1.0 10.762285813516078 -8.747063934170509 0.6660390818008679 0.9987060545060226 0.6305643290226961 0.6109186462637871 0.08551903020856323 0.8088743859986431 0.7502130399893102 0.10147330189549028 0.0385750230173492 1.7903422714235382e-09 8.747063934170509 -0.36814172548332647 S(ph)PVPTTLPGLR ddPTM_A459_Selumetinib_30min_R2 1 SPVPTTLPGLR 11 0 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(1)PVPTTLPGLR 119.03 0.0051384 5523000.0 7623.1 5943.6 8351.8 11380.0 7599.4 8128.3 7303.0 9460.7 5600.7 13042.0 True False 7199.438619687145 6399.455008313819 7814.454280752292 9830.02436840502 6644.695432502021 9247.899543639112 7642.603970619968 9488.229070696805 6720.996496633002 12665.443572814513 0.5684316209137937 0.5052689210230111 0.6169901777088542 0.7761294984965611 0.5246318768309381 0.7301678374288509 0.6034217377924515 0.7491430533915625 0.5306562267632813 1.0 13.628609983966113 -14.522878745280336 0.25427965468782937 3.29312001752047 0.596341208383801 0.5881577261937954 0.09396435815844924 130.53120120382462 1.287367652001132 156.132043664746 0.12711688658399362 3.0000000000000132e-15 14.522878745280336 -2.696778809136669 S(ph)PVQLEEAPFSR ddPTM_A459_Selumetinib_30min_R1 1 SPVQLEEAPFSR 12 0 Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 S(1)PVQLEEAPFSR 100.82 0.013098 7251400.0 218.57 417.04 353.32 415.59 478.2 305.85 396.68 344.35 119.25 268.0 True False 223.66225573681456 368.21276292336375 305.34108464783793 343.01500809048446 434.9468944330674 302.7734266895811 366.7581082310998 335.2167193935614 202.35854032460145 302.40041054106393 0.7396228574446421 1.2176331449568683 1.0097244382093016 1.13430734924186 1.4383144971756068 1.001233517335012 1.212822785441611 1.1085193925292016 0.6691741587338967 1.0 8.240316287948641 -8.198293782851382 10.196367663082741 0.8349640231344181 1.120212467998355 0.25486287658739204 0.18588106702654647 0.6969071620257767 110.36525387494986 0.12100925794334239 0.04560377409662098 6.334410687391764e-09 8.198293782851382 0.28524844486393686 S(ph)PVQLEEAPFSR ddPTM_A459_Selumetinib_30min_R2 3 SPVQLEEAPFSR 12 0 Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 S(1)PVQLEEAPFSR;S(1)PVQLEEAPFSR;S(1)PVQLEEAPFSR 153.2 0.00047525 13878100.0 5402.200000000001 1145.3 2746.71 5192.0 3232.8 2846.3999999999996 4409.0 7231.1 3031.5 3807.0 True False 5101.967350720034 1233.1408272800686 2569.9896689917296 4484.840643300431 2826.6667624013103 3238.46576295343 4614.02723626776 7252.141303826951 3637.8847071871296 3697.0820182261014 1.3799984218819175 0.33354435232998764 0.6951400202435426 1.2130757773808611 0.7645669607723701 0.8759518309272672 1.2480186302389955 1.961585182063828 0.9839880990610602 1.0 11.852171334131395 -7.326003159155527 4.219490484369484 1.3937299411729434 0.8527415585093566 0.22755272414684802 0.36906606492594224 0.2758697577814932 9.836613032809593 0.1558147986446688 0.10378076149422766 4.72059607383576e-08 7.326003159155527 -0.5409883826635867 S(ph)PVREPIDNLTPEER ddPTM_A459_Selumetinib_30min_R1 2 SPVREPIDNLTPEER 15 1 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 S(0.71)PVREPIDNLT(0.29)PEER;S(0.994)PVREPIDNLT(0.006)PEER 176.29 9.1386e-05 12309700.0 1247.04 1189.05 1428.74 1224.06 1497.07 1158.31 1318.29 1429.31 708.0999999999999 1210.37 True False 1276.0936056825608 1049.8354732256519 1234.7249555070534 1010.3008994519561 1361.6602828291757 1146.6584530613325 1218.8503239386316 1391.4000557468014 1201.5939824222246 1365.732779502193 0.9343655104680834 0.7686975731872783 0.9040750680064283 0.7397500555124765 0.9970180867486379 0.8395921004980837 0.892451541203324 1.0187937762275605 0.8798163157951027 1.0 10.415459516899228 -7.41187399213909 0.6128039460366437 0.9815501832787064 0.8423638251100268 0.23377825469121494 0.0791160969443095 1.0706925007709942 0.8113831473741497 0.06867946859254995 0.04559229493669941 3.873700216367809e-08 7.41187399213909 -0.13918635816867952 S(ph)PVREPIDNLTPEER ddPTM_A459_Selumetinib_30min_R2 3 SPVREPIDNLTPEER 15 1 G3XAC6;Q14498-2;Q14498;Q5QP23;H0Y4X3;Q14498-3;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 S(1)PVREPIDNLTPEER;S(1)PVREPIDNLTPEER;S(1)PVREPIDNLTPEER 97.081 0.0053663 39530000.0 43848.0 27367.2 43024.0 45949.0 52118.0 34907.6 46021.0 52745.0 39375.3 39831.0 True False 41411.10369745143 29466.176240582463 40255.882680989314 39690.66693355381 45570.47089916839 39715.80504035736 48161.06768888147 52898.47921759521 47251.46023780487 38680.97553663353 1.0705806439197036 0.7617743821552788 1.040715290204205 1.0261030489255378 1.1781106930979555 1.0267529318836277 1.2450841019578125 1.367558043294351 1.2215684734490346 1.0 15.239336559682608 -6.217741286054907 0.921615948366329 1.22005438397872 0.9166568283283256 0.38332675238310676 0.12484265010022892 0.5444830481646101 0.9794110175327955 0.059455937753737934 0.10093286266927251 6.057015903254967e-07 6.217741286054907 -0.3033975556503943 S(ph)PVSPLAAQGIPLPAQLTK ddPTM_A459_Selumetinib_30min_R1 2 SPVSPLAAQGIPLPAQLTK 19 0 K7EIF1;K7EPF0;K7EQS3;K7EM48;K7EN63;Q96SI1-2;Q96SI1 K7EIF1 KCTD15 BTB/POZ domain-containing protein KCTD15 1 S(0.932)PVS(0.068)PLAAQGIPLPAQLTK;S(0.984)PVS(0.016)PLAAQGIPLPAQLTK 269.39 1.2651e-58 124542000.0 4916.9 6366.700000000001 5463.5 5903.1 5187.0 4971.9 6102.0 5727.700000000001 2670.1 4725.8 True False 5031.4542033780635 5621.28380420147 4721.586708857301 4872.234399910822 4717.836765839228 4921.88720012401 5641.721227251615 5575.782789808333 4530.964683611892 5332.402463190153 0.9435623507622407 1.0541747069928573 0.8854520530756363 0.9137034260906045 0.8847488160180512 0.9230149513469864 1.0580073927646507 1.0456417774723958 0.8497041839751168 1.0 12.38056995663744 -7.199956215001673 24.999851757608273 0.9921424624575265 0.9341839640602612 0.12867703570113032 0.06884718417415732 489.5187572127433 199044.4559710115 0.02710874483234106 0.020998340397218804 6.310209599763661e-08 7.199956215001673 -0.0579584983972653 S(ph)PVSPLAAQGIPLPAQLTK ddPTM_A459_Selumetinib_30min_R2 2 SPVSPLAAQGIPLPAQLTK 19 0 K7EIF1;K7EPF0;K7EQS3;K7EM48;K7EN63;Q96SI1-2;Q96SI1 K7EIF1 KCTD15 BTB/POZ domain-containing protein KCTD15 1 S(0.919)PVS(0.081)PLAAQGIPLPAQLTK;S(0.944)PVS(0.056)PLAAQGIPLPAQLTK 153.06 1.3821e-05 84788000.0 185757.0 163578.0 184221.0 203225.0 198318.0 149358.0 165571.0 180854.0 138602.0 184135.0 True False 175433.36958418833 176123.90661382995 172368.42142465911 175545.4044173206 173403.51985458512 169930.70876306863 173270.37957271232 181380.25519800844 166326.27286345023 178818.5441098143 0.9810692199599439 0.9849308833745478 0.963929229391365 0.9816957480065175 0.969717770144109 0.9502969035398948 0.968973214916151 1.0143257574372206 0.9301399566328398 1.0 17.44813683124889 S(ph)PVSSLQIR ddPTM_A459_Selumetinib_30min_R1 2 SPVSSLQIR 9 0 Q5JT35;P55197-1;P55197 Q5JT35 MLLT10 Protein AF-10 1 S(0.987)PVS(0.012)S(0.001)LQIR;S(0.993)PVS(0.006)SLQIR 154.15 0.00092491 39399000.0 718.7 904.53 631.4300000000001 843.04 771.81 698.28 993.7 777.0699999999999 301.84000000000003 831.3499999999999 True False 735.44431165324 798.6272070954112 545.6852741967177 695.8188898207417 701.9999217741225 691.2559371875126 918.7444089675408 756.4595793209074 512.2004344786393 938.0618705347518 0.7840040563998112 0.8513587772628959 0.5817156536654072 0.7417622564960272 0.7483514081794416 0.7368980222951126 0.9794070496051621 0.8064069152386291 0.5460198847935842 1.0 9.873539269626235 -7.10469520240261 22.796873480166045 0.8227300427188922 0.738855029231268 0.1039859813015035 0.13126290877012411 45.5586768312055 9894.409189029986 0.05031556125195893 0.03897428857684226 7.857869240019582e-08 7.10469520240261 -0.08387501348762416 S(ph)PVSSLQIR ddPTM_A459_Selumetinib_30min_R2 3 SPVSSLQIR 9 0 Q5JT35;P55197-1;P55197 Q5JT35 MLLT10 Protein AF-10 1 S(0.998)PVS(0.002)SLQIR;S(1)PVSSLQIR;S(1)PVSSLQIR 172.21 0.00051016 97703000.0 16767.2 11002.9 18607.0 19246.5 20648.3 17481.2 16911.3 17998.6 16823.5 16745.6 True False 15835.346148419707 11846.787050100289 17409.84587776982 16625.09349793562 18054.27595585591 19889.076621466244 17697.708959105224 18050.97294617136 20188.670087864964 16262.11101770607 0.9737571051617036 0.728490110367688 1.070577236793803 1.0223207478927145 1.1102049381041947 1.223031659285265 1.0882786951728523 1.1100018273468673 1.2414544499102045 1.0 13.989226928296485 -5.556311000329044 1.9011945622250297 1.1290870076557409 0.8524053839878237 0.5251424554449843 0.09440708628704739 0.24654939155282216 1.7527652958108113 0.02664358733624618 0.06853260702417797 2.777723414520309e-06 5.556311000329044 -0.27668162366791715 S(ph)PVSTRPLPSASQK ddPTM_A459_Selumetinib_30min_R1 3 SPVSTRPLPSASQK 14 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.999)PVS(0.001)TRPLPSASQK;S(0.998)PVS(0.002)TRPLPSASQK;S(0.935)PVS(0.033)T(0.033)RPLPSASQK 159.41 0.0014167 1973310000.0 12178.7 14927.8 15581.3 17534.7 15545.0 13373.099999999999 15902.899999999998 14812.599999999999 7508.2 12368.3 True False 12462.440014374997 13180.046236254053 13465.445041954474 14472.593812084555 14138.957494692662 13238.578755803292 14703.33144950175 14419.72172989419 12740.867022768747 13955.891782444189 0.8929877222215294 0.9444073113861409 0.9648573700530788 1.037023934958449 1.013117449970396 0.9486014195421577 1.053557284529664 1.0332354216183788 0.9129382214611408 1.0 13.768586695211255 -5.0797596790266 1.6643730783017103 1.0012926996049445 0.8870757458239423 0.402026950234487 0.04058362127234708 0.5620444756597686 2.2850611937801224 0.011580010164916004 0.08597815066856214 8.32224162848907e-06 5.0797596790266 -0.11421695378100216 S(ph)PVSTRPLPSASQK ddPTM_A459_Selumetinib_30min_R2 3 SPVSTRPLPSASQK 14 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(1)PVSTRPLPSASQK;S(1)PVSTRPLPSASQK;S(1)PVSTRPLPSASQK 156.96 0.0015044 1821643000.0 283126.0 236287.0 281075.0 294154.0 294731.0 215419.0 239469.0 254222.0 200898.0 249379.0 True False 267390.9903631782 254409.45311754633 262990.94051132095 254089.71775604686 257704.2568514296 245091.01187101752 250604.78299882158 254961.7439312821 241083.21355912194 242178.78030554473 1.1041057768390132 1.0505026608713233 1.085937174923082 1.0491824157156737 1.0641075015998396 1.012025131028402 1.0347924895923837 1.052783169564277 0.995476206688957 1.0 17.885712936128428 -1.5228787452804022 0.1425932004382399 0.985064846294599 1.3666723403006718 0.6653790378590656 0.019455513804241008 44.812680237818064 0.4254650457856261 0.07694154288790334 3.4970743939486773 0.029999999999995534 1.5228787452804022 0.38160749400607274 S(ph)PVTTLLECMHK ddPTM_A459_Selumetinib_30min_R2 1 SPVTTLLECMHK 12 0 A0A3B3ITG9;A0A3B3ISX1;A0A3B3IRQ9;P55265-5;P55265-3;P55265-2;P55265;P55265-4 A0A3B3ITG9 ADAR Double-stranded RNA-specific adenosine deaminase 1 S(1)PVTTLLECMHK 145.61 0.00044879 2898900.0 9585.9 7906.4 8277.5 10302.0 10510.0 9695.9 12433.0 10855.0 9684.1 7637.3 True False 9053.154053398093 8512.795456917085 7744.934661860569 8898.849828058754 9189.639839407877 11031.422214383128 13011.159135522114 10886.586252858007 11621.190596361821 7416.79130491153 1.2206294718583945 1.1477733573654367 1.0442433046122974 1.1998247573941818 1.2390317404943478 1.4873577751982756 1.7542841102871394 1.4678296591207465 1.5668757712875194 1.0 12.856579459419716 -6.670072142987233 3.215356326466621 1.5054601165074826 1.1508031121225313 0.36520070185920983 0.1847805110078141 0.22623437114428516 4.665688558144397 0.062456831839407256 0.06120191241049554 2.1376069706413402e-07 6.670072142987233 -0.3546570043849513 S(ph)PVVELSK ddPTM_A459_Selumetinib_30min_R1 1 SPVVELSK 8 0 P25098 P25098 ADRBK1 Beta-adrenergic receptor kinase 1 1 S(1)PVVELSK 82.417 0.041367 13275000.0 5216.1 6600.7 3929.0 3880.4 4044.3 4121.8 5612.4 4852.2 2760.8 5066.1 True False 5337.6249812362075 5827.886975417824 3395.463380452154 3202.7609841293483 3678.493779079157 4080.338434294965 5189.052149430834 4723.503893833129 4684.875959145994 5716.383282992854 0.9337416189562529 1.0195059860238398 0.5939880536972032 0.5602775086229906 0.6435001988098417 0.7137972092309867 0.9077509139159871 0.8263098641209559 0.8195524560230666 1.0 12.480886936913636 -8.520715817580864 0.7907050712644804 0.9910760740825665 0.7496757246506136 0.197149147666157 0.14182927257055591 1.2925918818223783 1.8151608955959504 0.15564678372125093 0.057717037282388646 3.014978242532986e-09 8.520715817580864 -0.24140034943195288 S(ph)PYNGVR ddPTM_A459_Selumetinib_30min_R2 1 SPYNGVR 7 0 Q9UK58-6;Q9UK58 Q9UK58-6 CCNL1 Cyclin-L1 1 S(0.999)PY(0.001)NGVR 79.986 0.045736 41080000.0 11219.0 11031.0 15390.0 13016.0 13859.0 8335.9 17556.0 12962.0 14179.0 11942.0 True False 10595.492893215378 11877.042229744546 14399.82415536505 11243.19834614761 12117.908518968005 9484.094559233941 18372.388786554042 12999.717274025388 17015.196194361306 11597.203430957741 0.9136248196639905 1.0241298516881923 1.2416634959533392 0.9694749611906311 1.0448991941126329 0.8177915146264455 1.5842085461319515 1.1209355213450647 1.4671809713142305 1.0 13.501489332945027 -7.250964953614656 24.997154125252013 1.3031592313239728 1.0143145097953186 0.3766571629511343 0.18289137398017102 739.8113123522598 1765557.864917289 0.06673934781487689 0.05111578085403346 5.610932529074215e-08 7.250964953614656 -0.28884472152865426 S(ph)PYQEFTDHLVK ddPTM_A459_Selumetinib_30min_R1 2 SPYQEFTDHLVK 12 0 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 S(0.995)PY(0.005)QEFTDHLVK;S(0.996)PY(0.004)QEFTDHLVK 161.24 0.00028829 17942900.0 5136.4 7549.6 4570.5 4439.2 5742.0 5137.9 7003.6 6359.6 3239.4 5896.1 True False 5256.068126305413 6665.689322286183 3949.8512039594216 3663.977054104475 5222.637113832437 5086.217390839951 6475.312813369293 6190.922749107859 5497.02520358502 6652.921867877491 0.7900390581292484 1.0019190747557607 0.5937017272111086 0.5507320132219452 0.7850140460913959 0.7645088115941796 0.9733036013295521 0.9305569600929304 0.8262572915708626 1.0 12.69977237542594 -7.186432316232694 5.489552582499565 0.926412405850099 0.7432849966588564 0.3560469833633956 0.12173978283301372 0.287073260213379 15.532174759324768 0.0514785022669555 0.039434352975366356 6.509800566365316e-08 7.186432316232694 -0.1831274091912426 S(ph)PYQEFTDHLVK ddPTM_A459_Selumetinib_30min_R2 4 SPYQEFTDHLVK 12 0 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 S(0.993)PY(0.007)QEFTDHLVK;S(0.942)PY(0.058)QEFTDHLVK;S(0.996)PY(0.004)QEFTDHLVK;S(1)PYQEFTDHLVK 178.03 6.860899999999999e-05 23732000.0 69771.0 55369.7 64840.0 73736.0 78590.0 67800.0 78075.0 80825.0 70760.0 65080.0 True False 65893.40713544245 59616.37794835344 60668.26499245417 63693.02959830513 68716.82159648577 77138.83457287891 81705.64220267753 81060.18736870088 84913.9771995914 63200.97130185305 1.0426011780852245 0.9432826224081383 0.9599261489621344 1.0077856128840483 1.0872747709570563 1.2205324219537304 1.2927909258299946 1.2825781898438038 1.3435549399080473 1.0 15.947659110129022 -6.598145777114193 2.0106949413183632 1.2551575615156176 0.9808715616891744 0.6075173632306035 0.09018753062061326 0.1932926491945296 1.591584073981289 0.032443502980559674 0.0333355567000224 2.5226338724454944e-07 6.598145777114193 -0.2742859998264432 S(ph)QAGVSSGAPPGR ddPTM_A459_Selumetinib_30min_R2 1 SQAGVSSGAPPGR 13 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 S(0.997)QAGVS(0.001)S(0.002)GAPPGR 80.387 0.037174 1554100.0 3529.1 3710.3 3285.9 3861.4 4092.1 3439.0 3367.9 3330.0 2984.8 4165.9 True False 3332.966750106639 3994.8680795051437 3074.4887714174124 3335.470658713459 3578.013814161841 3912.6910338662315 3524.5140233672455 3339.6897486888242 3581.843402280109 4045.619642691913 0.8238457997719523 0.9874551817350283 0.7599549742574613 0.8244647182141106 0.8844167594017978 0.9671425836915226 0.8711926316983349 0.8255075967711659 0.885363360530054 1.0 11.982144972972327 -6.509777373127203 24.03058204954971 0.899770997507357 0.8527158449620039 0.1343207804151616 0.07036690481319835 1012.4150426217278 1856979.7410023843 0.02270874293422127 0.024576314339314835 3.0918799775698177e-07 6.509777373127203 -0.047055152545353085 S(ph)QAVKNT(ph)MEMYK ddPTM_A459_Selumetinib_30min_R2 1 SQAVKNTMEMYK 12 1 Q9UI47;Q9UI47-2 Q9UI47 CTNNA3 Catenin alpha-3 2 S(1)QAVKNT(1)MEMYK 66.29899999999999 0.036103 0.0 8428.0 9028.2 8524.3 10960.0 10318.0 8352.9 9135.1 8330.6 7507.6 8642.6 True False 7959.605499957135 9720.633909761555 7975.855818556094 9467.229092945438 9021.760595909653 9503.43615492331 9559.90025085725 8354.84066679493 9009.32977987072 8393.065681828453 0.9483549636922551 1.1581744118608979 0.9502911237575984 1.127982247707488 1.0749064689726384 1.1322961734350399 1.1390236432386167 0.9954456432866617 1.0734253872666004 1.0 13.03498215565143 -3.1697781835412675 16.561751156812953 1.0660503811939956 0.6032593679313742 0.0 0.07666088633620304 0.0 0.0 0.01646371516476701 0.0 0.0006764283738299763 3.1697781835412675 -0.4627910132626214 S(ph)QDDAMVDYFFQR ddPTM_A459_Selumetinib_30min_R1 2 SQDDAMVDYFFQR 13 0 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2;E9PR38;Q14671-4;E9PM68;E9PL65;E9PMX1 Q5T1Z4 PUM1 Pumilio homolog 1 1 S(1)QDDAMVDYFFQR;S(1)QDDAMVDYFFQR 204.9 2.9749e-05 13934700.0 2186.34 2264.62 1743.33 2106.74 1698.6999999999998 1879.76 2011.58 1402.74 1116.02 1753.55 True False 2237.277468122923 1999.4772376067247 1506.5953614262291 1738.8374074076555 1545.0528849298425 1860.851321085521 1859.844901067651 1365.5347784583248 1893.8044291242077 1978.6352235234433 1.1307174973560332 1.0105335303018446 0.7614315885589907 0.8788064554472202 0.7808679773619407 0.9404721491674553 0.9399635056307868 0.6901397297611314 0.957126612631421 1.0 10.95028994974033 -5.026348634499923 4.324261989164723 0.8601581614176173 1.1126639921236174 0.44743545543128327 0.0937383168627432 0.15414868143483895 6.821601571660871 0.022869906673383834 0.08083682393355802 9.4113378807013e-06 5.026348634499923 0.2525058307060002 S(ph)QDKSLLDGEGPQAVGGQDVAFSR ddPTM_A459_Selumetinib_30min_R2 1 SQDKSLLDGEGPQAVGGQDVAFSR 24 1 A1X283 A1X283 SH3PXD2B SH3 and PX domain-containing protein 2B 1 S(0.985)QDKS(0.015)LLDGEGPQAVGGQDVAFSR 79.29899999999998 0.0056633000000000005 0.0 11124.0 12351.0 9753.8 12601.0 9235.9 5384.0 5034.8 6010.9 4913.6 10082.0 True False 10505.772612900239 13298.281985275575 9126.251127134476 10884.722062062545 8075.603672006393 6125.597128914157 5268.9281762669325 6028.390723841938 5896.457297454952 9790.906463818117 1.073013275300288 1.358227865256278 0.9321150356057585 1.111717500548757 0.8248065387867248 0.6256414716605703 0.5381450834749607 0.6157132382093121 0.6022381399766265 1.0 13.257226718578497 -6.371567320068971 1.871312729195439 0.6406233812008723 1.1438283203563646 0.6421082765632089 0.15450041569790285 0.19618195187215845 1.358166044440117 0.05335219970050305 0.06465626449536019 4.2504281573138864e-07 6.371567320068971 0.5032049391554924 S(ph)QDSYPGSPSLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 2 S(0.828)QDS(0.007)YPGS(0.169)PS(0.145)LS(0.852)PR 151.31 0.0073576000000000015 5864300.0 70820.0 65575.0 73857.0 77073.0 83478.0 53649.0 61362.0 60832.0 53485.0 67745.0 True False 66884.10791492231 70604.39164314201 69105.12102942148 66575.52444165913 72990.74733721129 61038.66277286693 64215.45458649632 61009.01104872027 64183.49449576233 65789.0258273515 1.0166453610431108 1.073194058663026 1.0504049901996166 1.011954860319282 1.1094669121375818 0.9277939900348906 0.9760815543159939 0.9273432807596922 0.975595757629813 1.0 16.005559329697306 -6.772339587056308 24.999412056491646 0.9577417797846143 1.0511418072634637 0.6546436677857675 0.032978947458485945 123.47868623953849 283194.1628495956 0.01084128025779071 0.009651635452932284 1.689119645031074e-07 6.772339587056308 0.09340002747884946 S(ph)QEADVQDWEFR ddPTM_A459_Selumetinib_30min_R1 1 SQEADVQDWEFR 12 0 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(1)QEADVQDWEFR 223.68 1.3858e-08 38709000.0 1832.4 1673.1 1641.4 1843.4 1667.8 1744.2 1616.7 1377.3 918.55 1188.4 True False 1875.0913547702755 1477.2126741969125 1418.5068955648167 1521.484794903628 1516.947784474005 1726.6549316068892 1494.7510173873632 1340.7695298990898 1558.7122617623704 1340.94271599627 1.3983381485294495 1.1016225052532531 1.0578430224075004 1.1346381741394689 1.1312547257822045 1.2876425748910905 1.1147016196563024 0.9998708475051811 1.1624003346066174 1.0 10.38903189243892 -1.522878745280562 0.07549562457861632 0.887698232646414 1.754676868201617 0.27164984944420667 0.09997540034273472 355.08758633409747 1.9735577746999748 3.655358336059275 32.34443734334288 0.02999999999998449 1.522878745280562 0.8669786355552029 S(ph)QEADVQDWEFR ddPTM_A459_Selumetinib_30min_R2 5 SQEADVQDWEFR 12 0 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(1)QEADVQDWEFR;S(1)QEADVQDWEFR;S(1)QEADVQDWEFR;S(1)QEADVQDWEFR;S(1)QEADVQDWEFR 189.04 0.00010449 74663800.0 76410.0 73361.4 79288.4 83725.0 89622.7 52254.9 68770.0 67025.7 51623.5 68141.5 True False 72163.4380934652 78987.98348591992 74187.07066668266 72321.51056631895 78363.49518889634 59452.53815224676 71967.94126516982 67220.73369029796 61949.64248110665 66174.07784212069 1.0905091607870083 1.1936393533789904 1.1210896031476179 1.0928978978576007 1.1842023001190494 0.8984263943063883 1.0875548796746701 1.0158167047023217 0.9361617796761328 1.0 16.013978564972895 -6.749013530522511 24.99999926266837 0.9948281681042028 1.1363689971944817 0.6357644346400424 0.056209288178187634 151.52663163721945 304861.13511979504 0.018127817806393408 0.018005588631367902 1.7823232379827896e-07 6.749013530522511 0.14154082909027887 S(ph)QEDLNEPIKR ddPTM_A459_Selumetinib_30min_R1 2 SQEDLNEPIKR 11 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(1)QEDLNEPIKR;S(1)QEDLNEPIKR 95.822 0.0107 63439000.0 7322.3 8918.7 7166.5 7358.599999999999 7895.6 7170.1 8244.3 8554.1 4387.9 7693.5 True False 7492.895343284424 7874.494457808859 6193.328662766697 6073.558648029642 7181.444374081396 7097.975303929917 7622.42581347599 8327.217480367246 7445.945820463885 8681.035666036101 0.8631338047140864 0.9070915914580591 0.7134320029345841 0.6996352603171513 0.827256637382364 0.8176415323001391 0.8780548896139383 0.9592423992619749 0.8577255188105709 1.0 13.083651454189342 -7.375284195913958 1.9469559557596123 0.9335477221578973 0.7981523522146071 0.44800918051184924 0.06706571604864323 0.36157206552916016 2.6737853963134808 0.03980655404698222 0.022947827092281627 4.2142064171599824e-08 7.375284195913958 -0.13539536994329016 S(ph)QEDLNEPIKR ddPTM_A459_Selumetinib_30min_R2 3 SQEDLNEPIKR 11 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(1)QEDLNEPIKR;S(1)QEDLNEPIKR;S(1)QEDLNEPIKR 82.57799999999997 0.020392 72165800.0 171278.0 142541.0 169230.0 180890.0 174204.0 112559.0 149974.0 172711.0 126595.0 137012.0 True False 161759.05444015868 153473.43635844602 158341.9260436922 156252.46994734457 152318.9361164806 128062.98054113076 156948.0881678432 173213.56041615494 151917.53735983963 133056.10756007239 1.2157206264817828 1.1534490161539979 1.1900387659559613 1.1743351944727487 1.1447722236103397 0.9624735225574871 1.1795632011629682 1.301808414453671 1.1417554605018914 1.0 17.02167520910657 -11.992428910906986 1.6851154530268675 6.514358920756017e-05 1.161711592194042 0.2702579827117273 0.08017095593692333 1461458.3558427873 106977.58471016026 5554891.021364967 0.021844707670762332 1.0175859198507163e-12 11.992428910906986 1.1616464486048343 S(ph)QEDMNEPLKR ddPTM_A459_Selumetinib_30min_R2 2 SQEDMNEPLKR 11 1 E3W994;J3KR49;O75122;A0A0U1RQI6;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 S(1)QEDMNEPLKR;S(1)QEDMNEPLKR 82.48299999999998 0.020485 50375000.0 136124.0 113351.0 145168.0 149985.0 156770.0 117797.0 133197.0 144936.0 106620.0 130962.0 True False 128558.77302754707 122044.65721908926 135828.04892696772 129556.78426144349 137075.1510584178 134022.4674953012 139390.92442484846 145357.73976455347 127946.97921170742 127180.78677985993 1.010834861794591 0.9596155229825641 1.067991890646781 1.0186820473574851 1.0777976338177893 1.0537949236568547 1.096006149624812 1.1429221617897083 1.006024435382474 1.0 16.95652121336841 -5.508483786085647 1.1715424197312974 1.0702074295754225 0.9813517047625283 0.23316314706552843 0.045112911166662974 0.7616555326378815 1.8089699554113514 0.01492673383959876 0.06092145518350538 3.101103162700776e-06 5.508483786085647 -0.08885572481289417 S(ph)QEDQLSR ddPTM_A459_Selumetinib_30min_R2 1 SQEDQLSR 8 0 F5H875;F8VVT7;Q9HD42-2;Q9HD42 F5H875 CHMP1A Charged multivesicular body protein 1a 1 S(1)QEDQLSR 120.03 0.0075846 5723100.0 21468.0 17931.0 22584.0 20818.0 25293.0 19804.0 20472.0 19247.0 18166.0 18673.0 True False 20274.894503213083 19306.25004274766 21130.970027600004 17982.55248694691 22115.46721771108 22531.82123718722 21423.988564498428 19303.00558348763 21799.707600449085 18133.861971719474 1.1180682049324429 1.0646518691306117 1.165276875965784 0.991655970194957 1.2195674176963014 1.242527447949397 1.1814355153860796 1.0644729519608942 1.2021547111391193 1.0 14.146398588366118 -5.26198301275507 24.9975102913675 1.1393189989363104 1.09136003774682 0.03425612446903714 0.08469384271269405 159.1456175380707 7318436.627830372 0.022000347014536733 0.05068685480024954 5.470373596104027e-06 5.26198301275507 -0.04795896118949039 S(ph)QEEPKDTFEHDPSESIDEFNK ddPTM_A459_Selumetinib_30min_R1 1 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.623)QEEPKDT(0.373)FEHDPS(0.003)ESIDEFNK 62.847 0.004332 29231000.0 2573.1 2483.8 2502.8 2176.8 2055.9 1996.7 2419.8 2687.0 1409.5 2619.3 True False 2633.048223618966 2192.9955413127072 2162.9335068963223 1796.6627435967343 1869.9442079986259 1976.6150108585466 2237.272537807844 2615.7320313939263 2391.8185541930866 2955.5126691425717 0.8908939051791795 0.7420017393966782 0.7318302267754495 0.607902230416751 0.6326970706375346 0.6687892193783035 0.7569828954436194 0.8850349581322486 0.8092736597495218 1.0 11.529192689541192 -8.232629303872184 1.001181412463613 0.979014075281725 0.7074996352021545 0.5187703114978796 0.08208286961132083 0.4232926864853501 0.8650441319357071 0.08279863864708588 0.028830665932402275 5.852894502939406e-09 8.232629303872184 -0.2715144400795705 S(ph)QEEPKDTFEHDPSESIDEFNK ddPTM_A459_Selumetinib_30min_R2 4 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.499)QEEPKDT(0.499)FEHDPS(0.001)ESIDEFNK;S(0.932)QEEPKDT(0.064)FEHDPS(0.003)ESIDEFNK;S(0.607)QEEPKDT(0.327)FEHDPS(0.028)ES(0.037)IDEFNK;S(0.499)QEEPKDT(0.499)FEHDPS(0.001)ESIDEFNK 61.139 0.005843999999999999 89563300.0 246591.0 212148.0 217733.0 236470.0 213467.0 177616.0 221608.0 205898.0 158930.0 211338.0 True False 232886.45940198525 228419.06943666455 203724.29582976547 204262.37806649745 186649.3670408071 202080.99176248442 231913.21110792112 206497.12909175106 190720.44087522654 205236.12281793222 1.1347245124513583 1.1129574380008058 0.9926337188239133 0.9952554904172566 0.9094372105556988 0.9846268239132214 1.1299824218256866 1.0061441731431338 0.9292732597780424 1.0 17.646925150916935 -5.227453168501582 4.529610861012044 0.9949289812419696 1.128398475092911 0.4745897825515938 0.05499155803326946 0.18918359758552494 9.475140466964634 0.015463703271437984 0.04203320530831105 5.92306953970489e-06 5.227453168501582 0.13346949385094142 S(ph)QEGLRPR ddPTM_A459_Selumetinib_30min_R1 1 SQEGLRPR 8 1 Q27J81-2 Q27J81-2 INF2 Inverted formin-2 1 S(1)QEGLRPR 109.16 0.0069128 89925000.0 2071.7 2933.9 1822.1 1584.2 2239.9 1948.3 2622.8 2297.8 1403.2 2699.9 True False 2119.966579173531 2590.3976240668944 1574.668828078868 1307.5492091170279 2037.3014404864655 1928.7018709148635 2424.9600843716066 2236.8548796936993 2381.1279143268816 3046.458464253056 0.6958790359524281 0.8502980278452671 0.5168850475251604 0.42920303180224667 0.6687442039312294 0.6330963948946375 0.7959931549456293 0.7342476209476703 0.7816052449973898 1.0 11.572917355289873 -8.502350311393824 0.6598331881260346 0.9959649449027626 0.6301583669257105 0.4944064887041193 0.1103495251060325 0.7541971485012848 0.7601805400472331 0.12238677168332159 0.05040174552200577 3.145210295459442e-09 8.502350311393824 -0.36580657797705207 S(ph)QEGLRPR ddPTM_A459_Selumetinib_30min_R2 4 SQEGLRPR 8 1 Q27J81-2 Q27J81-2 INF2 Inverted formin-2 1 S(1)QEGLRPR;S(1)QEGLRPR;S(1)QEGLRPR;S(1)QEGLRPR 118.23 0.0046576000000000005 1482076000.0 213307.0 145863.0 213508.0 223472.0 223821.0 186664.0 221868.0 243382.0 181837.0 194867.0 True False 201452.25087557654 157050.22307653227 199771.12772993412 193034.7280892975 195702.60499487244 212375.27163291821 232185.30162310135 244090.20132594078 218209.48095028373 189240.68338472955 1.0645292929217587 0.8298967234082879 1.0556457742429306 1.0200487793465352 1.0341465772294094 1.1222495492745377 1.2269312151608787 1.289839990852819 1.1530791215050735 1.0 17.52986275025942 -6.745682492940421 1.8014696088570408 1.191298439291563 0.9836488661272675 0.4187039941484494 0.09282433523633564 0.29129703779571037 1.9533349887738798 0.037478449725420374 0.03466120047590434 1.7960462130445096e-07 6.745682492940421 -0.20764957316429555 S(ph)QEMVHLVNK ddPTM_A459_Selumetinib_30min_R1 4 SQEMVHLVNK 10 0 H0YE40;H0Y2P0;H0YD13;P16070-8;P16070-5;P16070-7;P16070-3;P16070-6;P16070-4;P16070-17;P16070-16;P16070-10;P16070-11;P16070-13;P16070-14;P16070-12;P16070-18;P16070 H0YE40 CD44 CD44 antigen 1 S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK 109.6 0.0065955 51049100.0 36727.299999999996 26052.9 25508.7 13354.5 32499.999999999996 21140.1 31464.9 44616.8 13822.3 34782.8 True False 37582.97463111457 23002.614356335373 22044.758649259315 11022.387270012208 29560.38073834103 20927.449787675032 29091.477260463675 43433.41752820864 23455.433559150857 39247.511193163155 0.9575887359110163 0.5860910324510561 0.5616855178602884 0.28084296137310966 0.7531784778111076 0.5332172449019024 0.741231134817317 1.1066540579973048 0.5976285590113227 1.0 15.260313550671572 -7.5248673383571125 24.917027439222306 0.8960733543787405 0.6030857487276016 0.29391171079547207 0.20078328935961373 78.1374506924413 979009.6423464029 0.09187855025942604 0.053508080863818384 2.986294687282958e-08 7.5248673383571125 -0.2929876056511389 S(ph)QEMVHLVNK ddPTM_A459_Selumetinib_30min_R2 9 SQEMVHLVNK 10 0 H0YE40;H0Y2P0;H0YD13;P16070-8;P16070-5;P16070-7;P16070-3;P16070-6;P16070-4;P16070-17;P16070-16;P16070-10;P16070-11;P16070-13;P16070-14;P16070-12;P16070-18;P16070 H0YE40 CD44 CD44 antigen 1 S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK;S(1)QEMVHLVNK 139.46 0.0015247 250072400.0 1402522.0 302368.6 771872.0 908772.0 526724.0 502001.0 2075629.0 1323593.0 916991.0 503543.0 True False 1324575.4419804076 325559.2993517123 722210.5958706918 784995.685880858 460552.2221476951 571147.08103864 2172149.861280837 1327444.4364973847 1100414.8228692815 489004.4052281651 2.7087188332431738 0.6657594407555679 1.4768999791192368 1.605293689562134 0.9418161006807403 1.1679794188605477 4.4419842399320135 2.714585844841236 2.25031678877379 1.0 18.89948793628549 S(ph)QESGYYDR ddPTM_A459_Selumetinib_30min_R1 1 SQESGYYDR 9 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 S(0.992)QES(0.008)GYYDR 134.49 0.0028702 17179000.0 1217.3 1723.3 1412.8 1299.4 1407.9 1369.3 1611.5 1487.5 809.61 1436.6 True False 1245.6607215465267 1521.5352348595657 1220.9495199549006 1072.4841827589103 1280.555693584934 1355.5260852249244 1489.9432575739063 1448.0466679190422 1373.849038425162 1621.0016036690029 0.7684512579920197 0.9386389448447778 0.7532068550650305 0.6616182120557014 0.7899780547326433 0.8362274794527059 0.9191497739431862 0.8933036615395744 0.8475309557470939 1.0 10.662669802787235 -7.0272924387058096 2.9150282956174367 0.9059397528931232 0.7831628059592871 0.4225283787877112 0.07268007776386802 0.31181300651805605 5.332775748217207 0.031402428530978244 0.024894140582042985 9.390907467703485e-08 7.0272924387058096 -0.12277694693383612 S(ph)QESGYYDR ddPTM_A459_Selumetinib_30min_R2 1 SQESGYYDR 9 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 1 S(1)QESGYYDR 116.71 0.0077619 61181000.0 43402.0 36855.0 52663.0 42514.0 43562.0 35489.0 34401.0 47346.0 29439.0 32426.0 True False 40989.89059197195 39681.659992497116 49274.719915139 36723.51985925934 38089.352110778884 40377.28761293362 36000.71466428832 47483.76902144775 35327.62259438624 31489.777127134123 1.3016888124194363 1.260144199569587 1.56478465110126 1.166204502210192 1.2095783325807676 1.2822347852738947 1.1432508562681194 1.507910609520698 1.1218759171193091 1.0 14.94259592620295 -13.818426381121085 0.2125995633484075 2.6942871629614294e-10 1.3306167060293652 0.30112422133017225 0.1368711920007223 137.91379612851435 1.8012865574716597 59.147035427704935 0.2837992090406953 1.5190554209633602e-14 13.818426381121085 1.3306167057599365 S(ph)QGGEEEGPLSDK ddPTM_A459_Selumetinib_30min_R1 1 SQGGEEEGPLSDK 13 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 S(1)QGGEEEGPLSDK 276.14 2.6373999999999998e-39 34517000.0 3009.7 3163.1 2608.7 2683.8 2394.6 2122.3 2535.9 2513.4 1513.7 2476.9 True False 3079.8201541432536 2792.7627815147057 2254.4528685633836 2215.1247111654343 2178.008852800968 2100.951588894222 2344.6150213351957 2446.7364673261977 2568.638343726199 2794.834242049111 1.1019688065239952 0.9992588252629657 0.8066499381768232 0.7925782065491489 0.7792980420921491 0.7517267239984331 0.8389102244633212 0.8754495814149982 0.9190664351682374 1.0 11.448547005918359 -2.1645029558602693 11.539486636453816 0.8732941961347781 1.0794435117242567 0.0 0.11048347495029315 0.0 0.0 0.027166364855950653 0.0 0.0068469482296028795 2.1645029558602693 0.20614931558947858 S(ph)QGGEEEGPLSDK ddPTM_A459_Selumetinib_30min_R2 1 SQGGEEEGPLSDK 13 0 E9PR76;E9PSH4;Q9H063 E9PR76 MAF1 Repressor of RNA polymerase III transcription MAF1 homolog 1 S(1)QGGEEEGPLSDK 182.28 0.00011734 25621000.0 109800.0 99773.0 110260.0 115740.0 106930.0 108360.0 118360.0 107560.0 94214.0 127210.0 True False 103697.75556422572 107425.26827924061 103165.99164201086 99976.01233736353 93496.49743367128 123285.60640585766 123863.97452589075 107872.98179248338 113059.43255910538 123537.11676872696 0.8394056642778673 0.8695788851892242 0.8351011772044773 0.8092791458337819 0.7568292014512972 0.9979640907166374 1.0026458263371623 0.8732030066270018 0.9151859418150677 1.0 16.914585039591593 -6.767634403241406 24.99997834966875 0.9526778449307038 0.8246967438770662 0.6791303072374859 0.04657431731339712 102.56396784270635 413893.6406361378 0.017563021044809106 0.015874398005072315 1.7075192039476115e-07 6.767634403241406 -0.1279811010536377 S(ph)QMEEVQDELIHR ddPTM_A459_Selumetinib_30min_R1 2 SQMEEVQDELIHR 13 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 S(1)QMEEVQDELIHR;S(1)QMEEVQDELIHR 159.26 0.00024101 2889600.0 2556.8 2424.2 2333.0 2377.8 2515.1 2506.5 2307.2 2524.8999999999996 1481.5 2062.93 True False 2616.368465333246 2140.3735370199943 2016.1914142516855 1962.5618668340278 2287.6096490769714 2481.2868857199105 2133.166046462624 2457.931449968935 2513.9972955211483 2327.7271601398393 1.124001347810912 0.9195122064440793 0.8661631177300702 0.8431236703515227 0.9827653722696359 1.0659698130475248 0.9164158424540069 1.0559362334463949 1.080022323307908 1.0 11.184706250218733 -6.5168718824713725 24.33194792136185 1.0208955610021302 0.9293728344760004 0.1905110158798614 0.08217056881866809 317.278533490932 1285205.7010050789 0.027553887566425003 0.028474844206508115 3.041782223686239e-07 6.5168718824713725 -0.0915227265261298 S(ph)QMEEVQDELIHR ddPTM_A459_Selumetinib_30min_R2 2 SQMEEVQDELIHR 13 0 A0A2R8Y4W2;A0A2R8YE63;Q12929;Q12929-2 A0A2R8Y4W2 EPS8 Epidermal growth factor receptor kinase substrate 8 1 S(1)QMEEVQDELIHR;S(1)QMEEVQDELIHR 137.69 0.00067971 1633350.0 9591.0 6611.9 8403.099999999999 11615.9 10771.0 8550.5 11169.0 11137.599999999999 9752.900000000001 7684.0 True False 9057.970615815015 7119.011469390627 7862.453694603512 10033.794381454829 9417.850686038264 9728.2537612891 11688.380630953636 11170.008572071056 11703.752518794448 7462.142954570361 1.2138564847872892 0.954017031398524 1.0536455469253603 1.34462639519783 1.262083927281249 1.3036809694634444 1.5663571044018687 1.4968901882574799 1.5684170874301215 1.0 12.86537428323466 -6.118152042289009 1.1351757195069847 1.4297397020000793 1.0552616821612977 0.33703551212851834 0.17414319865422245 0.48577674732429466 1.2851788276769927 0.06888381959316817 0.11973541448014537 7.618122602459179e-07 6.118152042289009 -0.3744780198387816 S(ph)QPCDLDAR ddPTM_A459_Selumetinib_30min_R2 2 SQPCDLDAR 9 0 Q9NYF3 Q9NYF3 FAM53C Protein FAM53C 1 S(1)QPCDLDAR;S(1)QPCDLDAR 85.67200000000003 0.03486 19618700.0 76132.0 62876.0 70072.0 96499.0 102850.0 71684.0 78204.0 73591.0 63697.0 83935.0 True False 71900.88822054314 67698.38702179476 65563.64380862506 83355.66972993985 89929.06350933398 81557.8203174373 81840.64095828608 73805.1376263542 76438.17984288247 81511.57846067975 0.8820941708941056 0.8305370635713021 0.8043476159678616 1.0226236726620337 1.1032673542534173 1.0005673041502914 1.0040370031328134 0.9054558753509718 0.9377585526669118 1.0 16.31471738369512 -5.763285113657312 24.999306626337564 0.9972690453489409 0.8381473443425763 0.6574991333635287 0.05200526825037911 32.129674398920784 435187.0263422474 0.016390337777556177 0.025783766556246694 1.7247052539051041e-06 5.763285113657312 -0.15912170100636458 S(ph)QQSVSLSK ddPTM_A459_Selumetinib_30min_R1 1 SQQSVSLSK 9 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(1)QQSVSLSK 122.69 0.0058642 4984800.0 905.56 1057.6 948.72 1277.4 1026.0 1011.9 943.96 896.21 664.83 791.28 True False 926.6577860869733 933.7757003350988 819.8890349459324 1054.326069767763 933.198481155012 1001.7212047316887 872.7563372134435 872.4395994996468 1128.1679527379858 892.8484957198997 1.0378667719429973 1.0458389131094405 0.918284612536486 1.1808566344928035 1.0451924213666042 1.121938615043536 0.9774965645316388 0.977141814856509 1.2635603443878227 1.0 9.802271580107687 -5.752331105935879 24.999726143359318 1.0758470304294738 1.005181030657275 0.13540212138430419 0.09206964256449077 452.6602000801252 1242417.1834993835 0.024593198107286773 0.04181801206549116 1.7687599422795104e-06 5.752331105935879 -0.07066599977219878 S(ph)QQSVSLSK ddPTM_A459_Selumetinib_30min_R2 1 SQQSVSLSK 9 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;A0A087WY36;A0A087WX73 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(1)QQSVSLSK 146.5 0.0017383 6128500.0 15717.0 22165.0 21504.0 22179.0 19194.0 20174.0 19596.0 18836.0 18220.0 21713.0 True False 14843.512060136025 23864.984228291913 20120.456051784913 19158.18193909096 16782.67812346287 22952.78537866164 20507.252828737353 18890.809641532338 21864.509109335144 21086.0892728509 0.7039480800855559 1.1317880674544494 0.9542052009468975 0.9085697063683501 0.7959123148108441 1.0885273737418053 0.9725488953108617 0.8958896738550253 1.0369162733976702 1.0 14.364003930355455 -6.771721418109919 24.99872120833042 0.9906302867273328 0.9154351579030788 0.15319373306977135 0.11335259598103296 545.2164985133053 1325577.1786002652 0.03947705749498518 0.03518935890881903 1.6915256272163287e-07 6.771721418109919 -0.07519512882425394 S(ph)QRYSGAYGASVSDEELK ddPTM_A459_Selumetinib_30min_R1 2 SQRYSGAYGASVSDEELK 18 1 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 S(0.832)QRY(0.001)S(0.167)GAYGASVSDEELK;S(0.853)QRY(0.01)S(0.135)GAYGAS(0.001)VS(0.001)DEELK 117.29 0.0048524 50847000.0 5744.5 3955.7 7228.0 7125.7 5373.4 5713.7 3988.4 4780.1 3167.33 3258.5 True False 5878.335673148792 3492.564805044963 6246.477300562018 5881.330260955182 4887.376918750821 5656.225365624521 3687.551776920736 4653.316220046935 5374.727677369556 3676.760215477826 1.5987813533238127 0.9499027949504384 1.6989079881430984 1.599595817044831 1.32926180450298 1.5383721086335371 1.0029350734914617 1.2656023094620539 1.461810768824114 1.0 11.844219377107267 -7.2446846961182025 24.742424136669747 1.2047205413521256 1.4419151827964798 0.24450640693155212 0.23065478417250762 1199.2386616733813 1770974.4514409618 0.08798399570008887 0.06795724876277992 5.692660760022497e-08 7.2446846961182025 0.2371946414443542 S(ph)QRYSGAYGASVSDEELK ddPTM_A459_Selumetinib_30min_R2 2 SQRYSGAYGASVSDEELK 18 1 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 S(0.706)QRY(0.259)S(0.034)GAY(0.001)GASVSDEELK;S(0.801)QRY(0.179)S(0.008)GAY(0.006)GAS(0.005)VS(0.002)DEELK 106.44 0.007884100000000002 20343900.0 91179.0 79349.0 93762.0 107498.0 90801.0 63074.0 66495.0 62126.0 41220.0 82094.0 True False 86111.63619845657 85434.81315275122 87729.455000347 92856.58695560686 79393.76660876068 71761.87097123543 69587.14925734285 62306.77637448704 49465.151783029374 79723.73291417203 1.0801254915040364 1.0716358859503927 1.1004183044814733 1.164729542400796 0.9958611282569197 0.9001318471689218 0.872853624807786 0.7815336048246071 0.620457045536013 1.0 16.282721642795664 -6.867266270725125 1.434499161263333 0.7906059347946235 1.102497736356199 0.6603985121197891 0.09208859574087097 0.23409218634333132 0.9978944033186045 0.0437216674402804 0.03611440132662599 1.3574809049146894e-07 6.867266270725125 0.3118918015615755 S(ph)QS(ph)SSRS(ph)RS(ph)RS(ph)HSR ddPTM_A459_Selumetinib_30min_R2 1 SQSSSRSRSRSHSR 14 3 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 5 S(0.999)QS(0.622)S(0.192)S(0.192)RS(0.935)RS(0.874)RS(0.594)HS(0.593)R 65.278 0.041085 0.0 14233.0 16553.0 16424.0 14260.0 14047.0 22959.0 13826.0 11823.0 13042.0 17866.0 True False 13441.98683921333 17822.561873716033 15367.297721099127 12317.763400127917 12282.290278226685 26121.393848948774 14468.936395699253 11857.402972596981 15650.764423926956 17350.16215855727 0.7747470436513247 1.0272273948128936 0.8857149334203672 0.7099509092514548 0.7079063680202516 1.5055417701710325 0.8339366666128266 0.6834174150210346 0.9020529192119306 1.0 14.082661526171611 -4.70641862494539 21.570052710516176 0.9091784538855633 0.7747334805851681 0.03320339173556308 0.22699473029397121 17383.15821021274 6811372.209961151 0.058273835935085665 55.289581243292396 1.965990319550842e-05 4.70641862494539 -0.13444497330039518 S(ph)QSAAVTPSSTTSSTR ddPTM_A459_Selumetinib_30min_R1 3 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 S(1)QSAAVTPSSTTSSTR;S(0.998)QS(0.002)AAVTPSSTTSSTR;S(0.994)QS(0.006)AAVTPSSTTSSTR 179.09 1.081e-06 18401600.0 1717.3400000000001 1863.86 1867.8 1871.41 1828.1 1632.0700000000002 2042.1 1757.67 983.1200000000001 1470.26 True False 1757.3506806380622 1645.6384047149943 1614.1630190909984 1544.6033742164473 1662.748677777269 1615.6528576009966 1888.062752895857 1711.050881883201 1668.282835756161 1658.9821925451674 1.0592944809986058 0.9919566419156667 0.9729839333685623 0.9310548245528524 1.0022703590484736 0.9738819770707147 1.1380850025877856 1.0313859241961791 1.0056062345049797 1.0 10.696082685202603 S(ph)QSAAVTPSSTTSSTR ddPTM_A459_Selumetinib_30min_R2 4 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 S(1)QSAAVTPSSTTSSTR;S(1)QSAAVTPSSTTSSTR;S(0.689)QS(0.311)AAVTPSSTTSSTR;S(0.992)QS(0.008)AAVTPSSTTSSTR 164.01 2.7767e-05 17893900.0 16449.9 13323.300000000001 15118.1 17681.699999999997 17322.2 15184.9 15853.2 16867.3 16571.5 11591.3 True False 15535.680412167176 14345.154268838336 14145.41790534271 15273.421957366183 15146.03037356719 17276.482140202188 16590.405212519854 16916.381050468175 19886.263046396674 11256.629051185766 1.3801361261461003 1.2743739003576053 1.2566300125038448 1.356837991899297 1.3455209641088526 1.53478293205214 1.473834230219413 1.5027927964532344 1.7666268432556964 1.0 13.45848723722979 -6.657106583103072 5.061252445698751 1.4877622571379665 1.314551043801683 0.10656428114030003 0.18156673252923936 0.37266322434141563 15.233231508606652 0.05760043475003317 0.05722177855020957 2.202385894524173e-07 6.657106583103072 -0.17321121333628353 S(ph)QSESSDEVTELDLSHGK ddPTM_A459_Selumetinib_30min_R2 3 SQSESSDEVTELDLSHGK 18 0 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 S(0.644)QS(0.328)ES(0.028)SDEVTELDLSHGK;S(0.622)QS(0.352)ES(0.023)S(0.002)DEVTELDLSHGK;S(0.367)QS(0.355)ES(0.032)S(0.097)DEVT(0.15)ELDLSHGK 192.44 1.6630000000000004e-10 15872400.0 57425.0 50682.0 56924.0 62725.0 68410.0 43051.5 58039.0 57647.0 53039.3 47560.0 True False 54233.548390488686 54569.14643168466 53261.57181416505 54181.74679333967 59815.72420684047 48981.453342393754 60737.928502096715 57814.74322602543 63648.64204186389 46186.81922427986 1.1742213320024157 1.1814874318731676 1.1531768740239656 1.173099765329953 1.2950821297387816 1.060507178564156 1.3150489581704623 1.2517584929432184 1.3780693953569454 1.0 15.495193574202151 -7.2954548296539725 24.997845893589343 1.257199069998199 1.1779803955492196 0.06415680932372747 0.10597899048624794 1397.5242022409996 1027030.7647982535 0.041370302160500895 0.027893742023325077 5.0646002296498414e-08 7.2954548296539725 -0.07921867444897934 S(ph)QSFSHQQPSR ddPTM_A459_Selumetinib_30min_R2 1 SQSFSHQQPSR 11 0 B3KNS5;Q8WVR3-2;Q8WVR3-3;Q8WVR3 B3KNS5 C7orf43 Uncharacterized protein C7orf43 1 S(0.855)QS(0.145)FSHQQPSR 169.58 0.00041306 8950700.0 6290.5 3145.8 6783.2 5953.0 7775.4 6048.6 4775.7 5588.8 4641.4 6191.1 True False 5940.899192866682 3387.072744658725 6346.776296989746 5142.1911305022095 6798.584739042056 6881.739746276037 4997.779512870021 5605.062482724353 5569.809691551492 6012.346856590391 0.9881165100038444 0.5633528512989914 1.0556237769337562 0.8552718685658718 1.1307705462118898 1.1446012531250866 0.8312526925141952 0.932258669770591 0.9263952703337772 1.0 12.553712526426033 -5.289875539214349 24.99904347864449 0.9829527647053533 0.7757345191678539 0.26966007775616974 0.13742201865218456 804.6599555789771 707398.3345949664 0.035298725051935494 0.0735030725050406 5.130083816639759e-06 5.289875539214349 -0.20721824553749946 S(ph)QSIEQESQEK ddPTM_A459_Selumetinib_30min_R2 4 SQSIEQESQEK 11 0 A0A0A0MRN0;Q5VTL8 A0A0A0MRN0 PRPF38B Pre-mRNA-splicing factor 38B 1 S(0.856)QS(0.004)IEQES(0.14)QEK;S(1)QSIEQESQEK;S(0.995)QS(0.005)IEQESQEK;S(0.997)QS(0.003)IEQESQEK 196.37 2.0439e-05 44692600.0 180360.0 145094.0 178315.0 184276.0 195620.0 144294.0 172963.0 181187.0 144889.0 169308.0 True False 170336.3132382853 156222.2432492568 166842.40703469238 159177.29090616922 171044.46673501114 164169.18872948378 181006.1222196826 181714.22417287744 173870.8485369074 164419.63812498705 1.035985209435874 0.9501434562853203 1.0147352769859743 0.9681160518378422 1.0402921979732622 0.9984767671407178 1.10087897214618 1.1051856471958876 1.0574822479826638 1.0 17.32702309786943 -7.248940568337236 24.004874340789957 1.0746521861629312 0.9998424411483566 0.40689473445548363 0.03759067770914385 373.9152422107001 718133.1018932845 0.013796217849207731 0.010595234400288662 5.637147929221384e-08 7.248940568337236 -0.0748097450145746 S(ph)QSLNIR ddPTM_A459_Selumetinib_30min_R2 1 SQSLNIR 7 0 O00443;A0A0C4DGF9;O00443-2 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 S(0.628)QS(0.372)LNIR 102.06 0.019521 51388000.0 220150.0 190100.0 236540.0 237250.0 259000.0 207470.0 212020.0 208230.0 165200.0 204410.0 True False 207914.9443302757 204680.0587321582 221321.27392527947 204936.14072092163 226462.10451062204 236047.10927485494 221879.35010965966 208835.9148256676 198244.6160736644 198508.15217903804 1.0473874349641494 1.0310914513352258 1.114922845716008 1.0323814839407002 1.140820172999101 1.1891053676322565 1.1177341971806918 1.052026894277444 0.9986724167119547 1.0 17.598838730504134 -8.048662054530709 3.3411255081008213 1.0008399775885612 1.0970163679756169 0.4012430509331607 0.04718932834734339 0.28617370626948024 6.190313748692765 0.03954160923733435 0.0139871302767858 8.94000878312295e-09 8.048662054530709 0.09617639038705561 S(ph)QSLPTTLLSPVR ddPTM_A459_Selumetinib_30min_R2 2 SQSLPTTLLSPVR 13 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 S(0.298)QS(0.16)LPT(0.268)T(0.268)LLS(0.005)PVR;S(0.999)QS(0.001)LPTTLLSPVR 138.19 0.0010013 38460800.0 20844.0 19272.8 23801.4 23521.5 19520.5 14813.6 16299.2 15679.2 16795.2 18602.5 True False 19685.57392514318 20750.961788180644 22270.0438370049 20317.83112314929 17068.160274515838 16854.038935527995 17057.145096252094 15724.823876168708 20154.70929709692 18065.39748990046 1.0896839627330916 1.1486579135489026 1.2327458529188227 1.1246822072145417 0.9447984902661493 0.9329459229972835 0.9441887512183424 0.8704388533360387 1.1156526895333745 1.0 14.140941378045204 -6.201878123689283 4.653224255838399 0.9583324349173944 1.158551225680918 0.6302365482192227 0.06781506436282522 0.13112723020628045 5.902438253713476 0.020101458079359535 0.02592688849148955 6.282346359256854e-07 6.201878123689283 0.20021879076352367 S(ph)QSMDAMGLS(ph)NKK ddPTM_A459_Selumetinib_30min_R1 2 SQSMDAMGLSNKK 13 1 P47736-4;F2Z357;J3KPC5;P47736;P47736-3;A0A0A0MQY8;X6R8W7;P47736-2 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 2 S(0.5)QS(0.5)MDAMGLS(1)NKK;S(0.668)QS(0.332)MDAMGLS(1)NKK 60.161 0.041786 0.0 140.3 0.0 0.0 195.44 193.49 167.47 299.81 281.669 0.0 0.0 True False 143.56871702372277 0.0 0.0 161.31007286316867 175.98886366343407 165.78540385059387 277.19509032158436 274.1982231301437 0.0 0.0 0.0 S(ph)QSNPILGSPFFSHFDGQDSYAAAVR ddPTM_A459_Selumetinib_30min_R2 1 SQSNPILGSPFFSHFDGQDSYAAAVR 26 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 S(0.654)QS(0.345)NPILGSPFFSHFDGQDSYAAAVR 129.57 4.138699999999999e-09 6749500.0 10964.0 8733.9 13986.0 13813.0 14539.0 11085.0 10995.0 11854.0 8486.8 12450.0 True False 10354.664772369488 9403.762046085205 13086.155986805432 11931.645571245921 12712.48083969088 12611.85813038882 11506.28928617918 11888.493177464663 10184.39714100469 12090.536151015222 0.8564272620366818 0.7777787460066928 1.0823470376627269 0.9868582685015206 1.0514406210698468 1.0431181854023757 0.9516773402321796 0.9832891634393242 0.842344542359234 1.0 13.561590601411938 -5.25162597333506 24.99939642951865 0.9942717526736038 0.8171029884633425 0.542183344647249 0.06450493563041354 508.8114951512125 1296177.65872393 0.016684301229009685 0.0429766068997557 5.602398881892434e-06 5.25162597333506 -0.1771687642102613 S(ph)QSPHYFR ddPTM_A459_Selumetinib_30min_R1 1 SQSPHYFR 8 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 S(0.994)QS(0.006)PHYFR 98.04 0.019782 51178000.0 3362.4 3161.1 3268.0 4246.6 4370.8 2909.1 3660.6 2991.8 1353.8 2496.4 True False 3440.7373779085196 2790.996942444479 2824.223549839053 3505.011028554709 3975.461911727415 2879.837095251462 3384.4779948340324 2912.4477452639944 2297.2997223601296 2816.8372569951935 1.2214895870764149 0.9908264794188788 1.0026221936767972 1.2443072527000056 1.4113211197611615 1.0223654519265597 1.2015170512351 1.0339424963339172 0.8155599748104474 1.0 11.459860498957712 -7.999667689845509 4.733700373705679 0.9092055531617389 1.151143321276963 0.3758664987676297 0.12865340693850152 0.20756914914424016 12.550812845908586 0.08664036047166944 0.03560512827614643 1.0007654652270688e-08 7.999667689845509 0.24193776811522416 S(ph)QSSDLLER ddPTM_A459_Selumetinib_30min_R2 2 SQSSDLLER 9 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 S(0.493)QS(0.485)S(0.021)DLLER;S(1)QSSDLLER 114.72 0.0083944 16620100.0 81215.0 78895.0 98914.0 90518.0 90265.0 56639.8 72728.0 61551.0 66781.0 77482.0 True False 76701.39542940419 84945.99281259142 92549.9809294205 78189.29224774026 78925.10372066149 64441.41832508766 76109.99610779803 61730.103219683435 80139.06601704223 75244.89333758745 1.0193568231306027 1.1289270147740103 1.2299835487066677 1.0391308802438288 1.0489097694186729 0.8564224822004888 1.0114971625559928 0.8203892713719496 1.0650432535999088 1.0 16.199306053029318 -6.351157382763916 2.2270647854147083 0.9448219303196597 1.12182249871803 0.404613944966152 0.08669058558181071 0.2777780002497269 2.703609169280552 0.028582788597424247 0.034466563428135435 4.4549477753402555e-07 6.351157382763916 0.17700056839837042 S(ph)QSSDTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R2 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.686)QS(0.098)S(0.215)DT(0.001)EQQS(0.796)PT(0.183)S(0.02)GGGK 176.44 1.4362e-07 0.0 11790.0 15657.0 13132.0 17453.0 15039.0 11612.0 9971.5 11785.0 10887.0 15318.0 True False 11134.758999109485 16857.84155481013 12287.101417040536 15075.871291895684 13149.666369634155 13211.447596759133 10435.1945081524 11819.29239888822 13064.704208196039 14875.729539056329 0.7485185160079108 1.1332446930115092 0.8259831146284737 1.013454247895129 0.8839678306270369 0.8881209867437014 0.7014912768314809 0.7945353112166087 0.8782563687982206 1.0 13.860672802697408 -6.7875779919218 2.6975048098097285 0.825251012016751 0.9363460586760465 0.06707735776330115 0.12038506440764105 0.5154929821777025 7.683625921776042 0.04283655291678417 0.03911509211989018 1.6308800045448703e-07 6.7875779919218 0.11109504665929548 S(ph)QSSDTEQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.858)QS(0.063)S(0.004)DT(0.036)EQQS(0.03)PT(0.008)S(0.001)GGGK 162.76 1.4319e-05 2852000.0 800.71 1017.7 831.56 969.5 719.38 649.65 677.59 688.03 366.26 542.46 True False 819.3649850895581 898.547210884106 718.6387194321187 800.1950247689422 654.3122060168549 643.1151108350051 626.478840769161 669.7812093635891 621.5164694279961 612.0900250078564 1.338634762229692 1.4679984547576523 1.1740735677286926 1.3073159046476397 1.0689803448576973 1.0506871286241766 1.0235076788926922 1.0942527765502996 1.0154004215638357 1.0 9.257600047073002 -5.9297849024881355 0.9293736904889646 1.0301243876767991 1.409068223161921 0.8046350346650999 0.06819138324632112 0.26319349525127694 0.450311486971292 0.02826336698285112 0.0696265433057413 1.1754796027081347e-06 5.9297849024881355 0.3789438354851218 S(ph)QSSGSSATHPISVPGAR ddPTM_A459_Selumetinib_30min_R1 2 SQSSGSSATHPISVPGAR 18 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(1)QSSGSSATHPISVPGAR;S(0.998)QS(0.002)SGSSATHPISVPGAR 159.01 1.6714e-05 9440800.0 2780.1000000000004 3683.7000000000003 3442.4 3150.9 3735.2000000000003 3011.1 3325.3 2843.1 1327.6 3126.6000000000004 True False 2844.8709208670816 3252.4106914943295 2974.940987749683 2600.6544647183687 3397.3518195031215 2980.8110678600533 3074.469943785611 2767.691752309667 2252.840235932417 3527.9295656630243 0.8063854076214894 0.9219035218700816 0.8432540764715026 0.7371616740964081 0.9629874282551436 0.8449179645965671 0.8714657950399892 0.7845087893044482 0.6385729062901593 1.0 11.784606042756211 -10.822873695827292 5.244478682690762 1.0000363756000408 0.8294021158961984 0.2671521019948122 0.08721971292981054 3.756684903563213e-05 5.0142416907622e-06 0.08552136099669842 0.020737558948190824 1.5035791825875768e-11 10.822873695827292 -0.17063425970384238 S(ph)QSSGSSATHPISVPGAR ddPTM_A459_Selumetinib_30min_R2 2 SQSSGSSATHPISVPGAR 18 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.855)QS(0.025)S(0.009)GS(0.047)S(0.047)AT(0.016)HPISVPGAR;S(0.988)QS(0.009)S(0.001)GSS(0.001)AT(0.001)HPISVPGAR 124.2 0.00087091 8183400.0 9930.9 8316.900000000001 13399.8 15343.3 16708.8 12247.1 11654.0 13777.5 9009.0 12309.6 True False 9378.980334542519 8954.779486951547 12537.671456599117 13253.516071331187 14609.691165432752 13934.026856895352 12195.934091962908 13817.59024401209 10811.051732491793 11954.189863818236 0.7845768254802354 0.7490912884071711 1.0488097980229432 1.10869211735089 1.2221397963279743 1.165618667231436 1.0202225521677852 1.1558784327019778 0.9043734335535041 1.0 13.545228741380244 -5.309996084836137 4.346989794071692 1.094105186236699 0.7635731066992789 0.6666364923972528 0.08787602028247898 0.10993334977213409 4.532490189245531 0.023362614506311854 0.05434521624498603 4.8978323474339964e-06 5.309996084836137 -0.33053207953742014 S(ph)QSSHSYDDSTLPLIDR ddPTM_A459_Selumetinib_30min_R2 1 SQSSHSYDDSTLPLIDR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 S(0.33)QS(0.33)S(0.33)HS(0.009)YDDSTLPLIDR 181.94 7.151799999999999e-08 3422100.0 4937.7 4658.1 5820.1 6363.8 6478.1 6533.7 5163.2 6615.9 5798.0 5374.0 True False 4663.282401179211 5015.3612918478 5445.641102445753 5497.039461832683 5664.263163051201 7433.657867976676 5403.29903068671 6635.151173678791 6957.76200965561 5218.83865667115 0.8935479151512413 0.9610109876527323 1.0434584130100832 1.0533070331281298 1.085349353693982 1.4243892860098983 1.03534509996391 1.2713846145056034 1.3332012095759322 1.0 12.349513085582299 -5.911361350691437 1.0666971358121862 1.2171714905814226 0.9204428129939723 0.420277834800326 0.12503495264987335 0.5196455661298263 1.1827502106259313 0.04820503656432517 0.11196128921996337 1.2264183764975628e-06 5.911361350691437 -0.29672867758745025 S(ph)QSSSNCSNPISVPLR ddPTM_A459_Selumetinib_30min_R1 1 SQSSSNCSNPISVPLR 16 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.998)QS(0.002)SSNCSNPISVPLR 210.57 4.4924e-08 8209800.0 769.96 818.71 651.06 528.67 554.3 688.52 703.47 706.48 366.67 617.38 True False 787.8985699186425 722.855052592047 562.6496280165892 436.3477088649785 504.1636628696132 681.5941139261414 650.4066915330542 687.7418554295427 622.2122094827808 696.6267367904559 1.1310197101373114 1.0376504581527144 0.8076773375206143 0.6263723251211231 0.7237213793895263 0.9784208356205595 0.933651634632415 0.9872458507667274 0.8931787665076961 1.0 9.444242034928426 -10.52451591022888 15.748270819543647 0.9999999999903634 0.8956339621980228 0.039219724983587056 0.14214958478710388 0.0 0.0 0.1537126580524601 0.03728079559674954 2.988712154512578e-11 10.52451591022888 -0.10436603779234055 S(ph)QSSSNCSNPISVPLR ddPTM_A459_Selumetinib_30min_R2 4 SQSSSNCSNPISVPLR 16 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.997)QS(0.002)S(0.002)SNCSNPISVPLR;S(0.994)QS(0.006)SSNCSNPISVPLR;S(0.999)QS(0.001)SSNCSNPISVPLR;S(0.883)QS(0.101)S(0.006)S(0.006)NCS(0.004)NPISVPLR 236.68 2.9439999999999998e-21 27713000.0 35649.6 28305.0 36372.700000000004 33367.100000000006 38809.5 30562.800000000003 30914.4 41140.9 34019.3 32365.100000000002 True False 33668.3379486559 30475.902485080187 34032.520081601426 28822.443418541952 33933.90364866792 34772.54827852484 32351.98085572148 41260.61320775735 40824.110578661086 31430.635468371307 1.071194948716083 0.9696241272547013 1.0827818010822083 0.9170175209325951 1.0796442115469047 1.1063266065210964 1.0293136099102203 1.312751479341802 1.2988636713929136 1.0 14.939883820562983 -7.746748698098241 24.92663678007566 1.2293556693004006 1.0355039143224678 0.37859214482152026 0.09658210408076094 188.63751337730469 320074.63034713635 0.04379350014060869 0.025144362535281004 1.7916422772231913e-08 7.746748698098241 -0.19385175497793283 S(ph)QSSSNCSNPISVPLRR ddPTM_A459_Selumetinib_30min_R2 2 SQSSSNCSNPISVPLRR 17 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.787)QS(0.208)S(0.002)S(0.002)NCS(0.001)NPISVPLRR;S(0.984)QS(0.004)S(0.004)S(0.007)NCSNPISVPLRR 73.984 0.012253 19011800.0 14966.2 14247.7 14337.6 20174.2 18082.1 12126.3 13517.7 15028.7 6826.5 14980.6 True False 14134.438518445495 15340.45277642385 13415.134425598557 17426.43915756387 15810.464941974986 13796.58775340858 14146.29983481439 15072.431028864785 8191.990748346669 14548.0711537268 0.9715678710318004 1.0544664384937426 0.922124609086888 1.1978522082702154 1.0867739630160385 0.9483448085744541 0.9723831898629746 1.0360432575285872 0.5630980672134062 1.0 13.828540266606137 -8.217485522069115 24.963349488941965 0.7815488078387488 1.025020529854996 0.38128925893658605 0.1233730613306964 371.84998746721726 211190.64132401897 0.07868445155865107 0.02973960800421669 6.060584041580106e-09 8.217485522069115 0.24347172201624712 S(ph)QSYIPTSGCR ddPTM_A459_Selumetinib_30min_R2 2 SQSYIPTSGCR 11 0 A0A087WZ32;A0A087X038;A8K727;Q9HB19;E5RHB5 A0A087WZ32 PLEKHA2 Pleckstrin homology domain-containing family A member 2 1 S(0.692)QS(0.307)YIPT(0.001)SGCR;S(0.911)QS(0.089)YIPTSGCR 109.95 0.0090995 41046000.0 105903.0 85119.0 112911.0 128021.0 145938.0 93311.0 98490.0 106815.0 93679.0 94159.0 True False 100017.33522329874 91647.35359927703 105646.4291882016 110584.31895145675 127603.96373772644 106163.7432570782 103069.9801542327 107125.81396582474 112417.41760995671 91440.38501553758 1.0937982731186418 1.0022634264248154 1.1553585340902721 1.2093597258220885 1.3954880408262054 1.1610159257207722 1.1271822634683681 1.1715372146302958 1.229406652113885 1.0 16.480543857673553 -5.429726283767412 4.5187824680666075 1.1966225034703175 1.049578355672359 0.23608799299141703 0.09514646960008508 0.28702857478185956 9.910058892154026 0.025506508093583503 0.05494746835566305 3.7176946480845145e-06 5.429726283767412 -0.1470441477979585 S(ph)QTLPIIR ddPTM_A459_Selumetinib_30min_R2 1 SQTLPIIR 8 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 S(0.709)QT(0.291)LPIIR 99.973 0.018218 10131000.0 30355.0 23566.0 28188.0 27156.0 24038.0 22183.0 24147.0 24094.0 17995.0 17613.0 True False 28667.99062069279 25373.43642336688 26374.414768773873 23457.305953287072 21018.131537553425 25238.50689277542 25269.883346372775 24164.109551023583 21594.502822309867 17104.466925930214 1.6760528547798461 1.4834391818958697 1.541960640047221 1.3714140320693662 1.2288095050591803 1.4755506267496752 1.4773850278878826 1.4127367813136005 1.2625066256565296 1.0 14.062085521638249 -13.035185031751 0.10088834028689284 2.174893223018315e-14 1.7559775698961253 0.6974527189305211 0.0989640913081955 82.17333350937757 0.7805764776904933 19.703336212184336 1.9885273455974237 9.221784480718703e-14 13.035185031751 1.7559775698961035 S(ph)QVIAEK ddPTM_A459_Selumetinib_30min_R1 1 SQVIAEK 7 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 S(1)QVIAEK 112.83 0.014394999999999996 10175000.0 1919.3 2841.4 1918.1 1734.2 2171.0 2147.1 2383.1 2510.7 1180.0 1902.1 True False 1964.0159556923106 2508.727567068977 1657.632555369121 1431.3545249657543 1974.6334333211814 2125.5021234108194 2203.340848355182 2444.108080097034 2002.3738162098932 2146.2530630229785 0.9150905778678361 1.1688871225350548 0.772337886863332 0.6669085531552855 0.9200375609667985 0.9903315503797434 1.0265988136794064 1.1387790760585004 0.9329625898772475 1.0 11.067604477831795 -6.813186199617606 3.228984327198994 1.0323839673263737 0.8838055800867003 0.20624602083165733 0.12835324986996288 0.4250189906813972 9.031511599063176 0.051713204862379326 0.04670595451303489 1.5374953125194728e-07 6.813186199617606 -0.14857838723967343 S(ph)QVIAEK ddPTM_A459_Selumetinib_30min_R2 1 SQVIAEK 7 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 S(1)QVIAEK 91.701 0.02799 16014000.0 106850.0 74959.0 97476.0 104560.0 109340.0 111370.0 118630.0 109610.0 98402.0 113930.0 True False 100911.70475444006 80708.11426882628 91204.50028384404 90318.74762393937 95603.73168799776 126710.20658379812 124146.53006088536 109928.94695308756 118085.14958160266 110640.54487431065 0.9120680386116797 0.7294623716876297 0.8243316262356963 0.8163259474774175 0.8640931025475792 1.1452420695120658 1.1220708484572062 0.9935683801807784 1.067286406766608 1.0 16.75552064093238 -6.6533723705566175 5.450526684286168 1.0679775467963908 0.8177087094516313 0.7946898385931025 0.06027131380126162 0.09044864033127366 4.0080816068923575 0.02025779809281211 0.020159021378539085 2.2214044086510472e-07 6.6533723705566175 -0.25026883734475946 S(ph)QVMNVIGSER ddPTM_A459_Selumetinib_30min_R2 1 SQVMNVIGSER 11 0 A0A096LNH6;Q14185 A0A096LNH6 DOCK1 Dedicator of cytokinesis protein 1 1 S(1)QVMNVIGSER 103.83 0.012897 3102000.0 4688.4 5141.9 5699.6 5384.7 6025.2 3649.7 6089.2 7037.4 4184.2 4603.0 True False 4427.837497152238 5536.267196185611 5332.893941255269 4651.294570874387 5268.260510028577 4152.413046322067 6372.359865520896 7057.877668895714 5021.15691631614 4470.099429969725 0.9905456392011904 1.238510973395307 1.1930146129414816 1.0405349240533313 1.1785555539788648 0.9289308015124377 1.4255521527770703 1.5789084291003155 1.1232763375802912 1.0 12.126091206793019 -7.275156104955967 24.77652918750437 1.330176599213445 1.1073133379353761 0.1958550672234074 0.17387804064290752 954.2165929550399 1723594.664746708 0.0701513057924935 0.04758824097710925 5.3069365479257135e-08 7.275156104955967 -0.222863261278069 S(ph)QVNGEAGSYEMTNQHVK ddPTM_A459_Selumetinib_30min_R1 2 SQVNGEAGSYEMTNQHVK 18 0 Q05D32;H0YMH7;Q05D32-2 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 S(1)QVNGEAGSYEMTNQHVK;S(1)QVNGEAGSYEMTNQHVK 202.15 7.6937e-11 12866600.0 3340.2 2743.58 2960.5 3401.3 2800.4 2761.0 3102.3999999999996 2900.6 1749.7399999999998 2225.71 True False 3418.020161102202 2422.3603781442616 2558.4803608624607 2807.326805308513 2547.1043144507753 2733.226846787421 2868.3834702434283 2823.6666655233444 2969.1809840466926 2511.4015587513136 1.3610010510631623 0.9645452236434369 1.0187460272719409 1.1178327080056187 1.0142162672373323 1.0883272877103733 1.1421444970630696 1.1243389794371599 1.1822804575796275 1.0 11.294277010404576 -7.142485687391836 6.765589295474032 1.1223542589147897 1.0818422999913029 0.0 0.10977531892797594 1.161311939409804 60.00040027782882 0.04075911459746963 0.031524075744398826 7.203014891017653e-08 7.142485687391836 -0.0405119589234868 S(ph)QVNGEAGSYEMTNQHVK ddPTM_A459_Selumetinib_30min_R2 2 SQVNGEAGSYEMTNQHVK 18 0 Q05D32;H0YMH7;Q05D32-2 Q05D32 CTDSPL2 CTD small phosphatase-like protein 2 1 S(1)QVNGEAGSYEMTNQHVK;S(1)QVNGEAGSYEMTNQHVK 178.2 1.2257e-09 22495000.0 37715.0 25305.0 37393.0 43434.0 38975.0 33320.0 38753.0 37697.0 34615.0 39469.0 True False 35618.951285107214 27245.81213160057 34987.175090420096 37518.214272170844 34078.61205907914 37909.52755115523 40555.091287612726 37806.69202892572 41538.96722390978 38329.42741722249 0.9292847215636364 0.7108327456871495 0.9128019239520226 0.9788357614576015 0.8890978643674353 0.9890449742048955 1.0580667132374166 0.9863620350336386 1.0837356575080261 1.0 15.2261648262007 -6.134551904572464 0.7057060419941458 1.035965976263826 0.8134104892297322 0.5315311830767493 0.06786735524486762 0.6335111086325631 0.6506064728965696 0.039483177424216524 0.08485214452727778 7.335810354654271e-07 6.134551904572464 -0.22255548703409378 S(ph)QY(ph)LRSRMPEGTRPEAK ddPTM_A459_Selumetinib_30min_R1 1 SQYLRSRMPEGTRPEAK 17 3 Q8NI17-6;Q8NI17;Q8NI17-12;Q8NI17-2 Q8NI17-6 IL31RA Interleukin-31 receptor subunit alpha 2 S(0.928)QY(0.919)LRS(0.153)RMPEGTRPEAK 48.824 0.04449 5208800.0 1643.0 1722.7 1920.8 1439.7 998.52 1974.4 1764.3 1372.3 669.25 853.87 True False 1681.27870327852 1521.0054831384984 1659.9659101991585 1188.283421516087 908.2040423030243 1954.539328611767 1631.2174305539213 1335.902146141379 1135.6683699139573 963.4725318981278 1.7450198605727236 1.5786703126263293 1.7228990503018036 1.2333339894756121 0.9426361543631974 2.0286404271029377 1.6930606494201508 1.3865492807662416 1.1787241797922232 1.0 9.912099726395112 -12.573165300069801 0.16187257310922606 1.589797851251338e-11 1.673859628245625 0.2568401868417368 0.29315856272349455 103.50654040439598 1.712851636221668 36.56283870251583 1.439059673320455 2.6719892093033293e-13 12.573165300069801 1.6738596282297271 S(ph)RADLTAEMISAPLGDFR ddPTM_A459_Selumetinib_30min_R1 3 SRADLTAEMISAPLGDFR 18 1 Q9H3Q1;Q9H3Q1-2;J3KRZ9;J3QQS6;J3QR93 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 S(0.993)RADLT(0.007)AEMISAPLGDFR;S(0.997)RADLT(0.003)AEMISAPLGDFR;S(0.999)RADLT(0.001)AEMISAPLGDFR 127.74 0.00039221 13015900.0 3798.4100000000003 4283.48 4863.74 4934.88 4508.459999999999 3659.0099999999998 4418.53 3747.7200000000003 2504.23 3741.84 True False 3886.9055625807446 3781.968170264172 4203.270822611445 4073.0958471704585 4100.670589033263 3622.2036815152637 4085.236724721089 3648.318291289783 4249.495408277373 4222.141612608115 0.9206004722754225 0.8957464048506801 0.9955305170389552 0.9646990131755464 0.9712299977783512 0.8579067245633536 0.9675745390732036 0.8640918818059568 1.0064786542420971 1.0 12.043759252826359 -8.314957765805254 24.989101708457184 1.0032395323498287 0.9321608329994568 0.3064805872395898 0.0441391855808732 467.96119474782756 218498.75246246412 0.04206648147073094 0.010861566329899675 4.8421945458437256e-09 8.314957765805254 -0.07107869935037181 S(ph)RADLTAEMISAPLGDFR ddPTM_A459_Selumetinib_30min_R2 2 SRADLTAEMISAPLGDFR 18 1 Q9H3Q1;Q9H3Q1-2;J3KRZ9;J3QQS6;J3QR93 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 S(0.946)RADLT(0.054)AEMISAPLGDFR;S(0.91)RADLT(0.09)AEMISAPLGDFR 100.62 0.0015078 2198900.0 9915.7 7592.8 8432.6 10003.6 8925.2 8886.1 9607.5 9452.5 10259.2 9819.8 True False 9364.6250896921 8175.143345300013 7890.0556967206785 8641.092422827463 7803.936583699631 10110.079615015624 10054.267786900082 9480.005210054385 12311.326665998415 9536.276859095526 0.9820001273096735 0.8572678274858087 0.8273727591282428 0.9061285185513199 0.8183420740617844 1.0601705219341253 1.054317941420766 0.9940992014103 1.2909992912229784 1.0 13.219210405680913 -6.815343341894772 7.212303770482428 1.0792529233362735 0.8759490838321989 0.567783969253703 0.08801081547066447 0.16286658241371166 17.780608652381673 0.030092158548530683 0.026685165328543405 1.5298775021964913e-07 6.815343341894772 -0.2033038395040746 S(ph)RDATPPVS(ph)PINMEDQER ddPTM_A459_Selumetinib_30min_R2 1 SRDATPPVSPINMEDQER 18 1 P17275 P17275 JUNB Transcription factor jun-B 2 S(0.748)RDAT(0.255)PPVS(0.998)PINMEDQER 87.53200000000002 0.013503 5445100.0 28341.0 20524.0 29596.0 32215.0 28429.0 19373.0 20072.0 21792.0 18058.0 22456.0 True False 26765.920678012015 22098.12480493856 27691.825581688372 27827.261426025296 24857.494861515348 22041.454899415676 21005.387771913454 21855.411112140206 21670.104582676944 21807.636932305068 1.22736455862221 1.013320465373448 1.2698223868844163 1.2760328646522434 1.1398527469380384 1.0107218387685206 0.9632124671333284 1.0021907086945476 0.9936933859429589 1.0 14.412545828081658 -6.712334028199093 3.5152809129964724 0.9897349573769078 1.1905056323545318 0.6631956401487435 0.06906451538682791 0.15333905436017922 3.8806288817898213 0.02546561131765652 0.024476888538781983 1.9393936611631174e-07 6.712334028199093 0.20077067497762402 S(ph)RDATPPVSPINMEDQER ddPTM_A459_Selumetinib_30min_R1 1 SRDATPPVSPINMEDQER 18 1 P17275 P17275 JUNB Transcription factor jun-B 1 S(0.602)RDAT(0.391)PPVS(0.008)PINMEDQER 57.197 0.033604 3132100.0 819.97 822.69 1170.6 1080.0 1198.5 713.9 925.08 849.9 412.27 464.71 True False 839.0737056161223 726.3690723417955 1011.6389496455306 891.3982741108387 1090.0958866123608 706.7188141693376 855.3004708138191 827.3578911357271 699.5920789905524 524.3600551587232 1.60018616475684 1.3852486763545029 1.9292830178288631 1.6999736447144385 2.0789071857931476 1.3477739336102073 1.6311320101507742 1.5778430927300264 1.334182632921546 1.0 9.034413977509502 -8.562458222958725 0.8607639727441965 0.9970048141221293 1.693028158917337 0.516931220558926 0.2052836184978683 0.5696132289490218 0.9316235667432062 0.2007690954927982 0.07095518386999831 2.7386830697385523e-09 8.562458222958725 0.6960233447952078 S(ph)RDATPPVSPINMEDQER ddPTM_A459_Selumetinib_30min_R2 1 SRDATPPVSPINMEDQER 18 1 P17275 P17275 JUNB Transcription factor jun-B 1 S(0.75)RDAT(0.25)PPVSPINMEDQER 83.229 0.0049139 12564000.0 22888.0 21308.0 21166.0 21466.0 23308.0 14044.0 16567.0 18441.0 16254.0 16210.0 True False 21615.97658792346 22942.255083981225 19804.202603798338 18542.293769084557 20379.84066383623 15978.433521261226 17337.39832688771 18494.660256928117 19505.25417470545 15741.975181361997 1.3731425909955757 1.4573936764392903 1.2580506814193106 1.1778886420198431 1.2946177610523308 1.0150208812537824 1.1013483458806772 1.1748627503126299 1.2390601528707184 1.0 13.942328949974037 -5.583234993619699 1.0306547602128406 1.129535254748415 1.4461553534881213 0.6064861061097385 0.08744420110904937 0.4922153133153377 0.905006934235663 0.03262718156320149 0.12919807495278576 2.610748315010295e-06 5.583234993619699 0.3166200987397063 S(ph)RDESASETSTPSEHSAAPSPQVEVR ddPTM_A459_Selumetinib_30min_R2 1 SRDESASETSTPSEHSAAPSPQVEVR 26 1 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(0.443)RDES(0.238)AS(0.238)ET(0.043)S(0.015)T(0.02)PS(0.002)EHSAAPSPQVEVR 76.48100000000002 0.00010098 4052200.0 833.8 861.03 2079.1 983.94 2958.7 2003.1 794.16 2513.7 2095.6 2103.8 True False 787.4607339658596 927.0682323521847 1945.3329695529226 849.9256746088258 2587.0016548864014 2279.008842668637 831.0900135981866 2521.014450834562 2514.7785559562412 2043.0578276711506 0.38543242550480017 0.4537650475654599 0.9521673558160499 0.4160066656447227 1.2662400544165133 1.1154891515070051 0.4067873176872008 1.2339417987537957 1.2308895626428733 1.0 10.99651432403117 -4.967103353382811 0.5399843590626019 1.0469723015920323 1.82504845558127e-17 0.3801137773617751 0.2867676179893047 3.9831709916222042 1.0236190614417697 0.1753472297893735 2.5661408575716123 1.0786899850839319e-05 4.967103353382811 -1.0469723015920323 S(ph)RDFNEECPR ddPTM_A459_Selumetinib_30min_R1 1 SRDFNEECPR 10 1 A0A0A0MTH3;Q13418-3;Q13418-2;Q13418 A0A0A0MTH3 ILK Integrin-linked protein kinase 1 S(1)RDFNEECPR 123.01 0.020352 6344800.0 1116.0 1545.6 1610.8 1487.4 1477.9 1370.9 1252.2 1142.6 825.14 1143.3 True False 1142.0006286420137 1364.6404334700535 1392.0622074910489 1227.6535119559817 1344.224205944437 1357.1099906776094 1157.745545847996 1112.2945363121335 1400.2023141588388 1290.0536916850692 0.8852349603762084 1.057816773259692 1.0790730777048017 0.9516297808910725 1.0419908989901112 1.051979463664765 0.8974398145675222 0.8622079402441408 1.0853829752852329 1.0 10.333215396136831 -7.252982748395874 24.853391740276205 0.9497750099135842 1.015167516323051 0.08214892337664359 0.07759899756110625 1173.299356994517 3448244.192070266 0.029577572801946044 0.02252024647854199 5.5849237944899424e-08 7.252982748395874 0.0653925064094667 S(ph)RDFNEECPR ddPTM_A459_Selumetinib_30min_R2 1 SRDFNEECPR 10 1 A0A0A0MTH3;Q13418-3;Q13418-2;Q13418 A0A0A0MTH3 ILK Integrin-linked protein kinase 1 S(1)RDFNEECPR 72.848 0.036822 3631100.0 8900.8 7077.4 12879.0 11654.0 12109.0 9210.6 3026.7 8481.4 7652.0 7419.7 True False 8406.1291687255 7620.2138225722165 12050.379161594965 10066.705095728665 10587.759164166497 10479.276544497907 3167.4475472922695 8506.07946982864 9182.613814743825 7205.473982304231 1.166630979359572 1.0575589949095001 1.6723922938573135 1.3970913114739252 1.469404953812719 1.454349369692228 0.43958906174266066 1.180502419510297 1.2743941394133418 1.0 12.814877619909913 S(ph)RDRHDDYYR ddPTM_A459_Selumetinib_30min_R2 1 SRDRHDDYYR 10 2 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 S(1)RDRHDDYYR 68.626 0.031054 3233500.0 1058.2 807.12 787.48 2105.4 2277.7 516.52 0.0 524.86 591.86 2228.2 True False 999.389480310233 869.0235087001563 736.8143941433964 1818.6408879824196 1991.5549631036445 587.6659414982801 0.0 526.3872557047494 710.2485379501156 2163.8660764411343 0.4618536660798843 0.4016068823119688 0.3405083161871181 0.8404590782131492 0.9203688642224632 0.2715814753493442 0.0 0.2432624003101373 0.3282312827410496 1.0 11.079395496935362 -10.898046523338778 5.568202520447231 1.0001908344520305 0.4247471444953701 0.3077909491038936 0.25953568727199505 0.0006970988678068674 7.822492207219575e-05 0.2849028612816689 0.06907659627960461 1.2646008711790307e-11 10.898046523338778 -0.5754436899566604 S(ph)RDSGDENEPIQER ddPTM_A459_Selumetinib_30min_R2 1 SRDSGDENEPIQER 14 1 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7 Q8WX93 PALLD Palladin 1 S(0.891)RDS(0.109)GDENEPIQER 143.97 0.0025329000000000003 5576700.0 7590.1 7477.7 8135.9 9365.9 9930.7 9042.3 6743.7 8358.9 7828.2 7673.8 True False 7168.27262757768 8051.215545404845 7612.445051698149 8090.248262921322 8683.116684415583 10287.794747173191 7057.29541238804 8383.22301510961 9394.058738183168 7452.237455073146 0.9618953597215082 1.080375604500356 1.021497918925804 1.0856133224007574 1.1651690833475135 1.3804974424385426 0.9470035616731124 1.1249269854388082 1.2605688955587584 1.0 12.863457929123946 -6.013981264465121 3.3018925364611 1.153594449452534 1.0278587860408823 0.18424632385543105 0.1172372074695172 0.42835483044757694 9.712792937770597 0.03549474647162033 0.05141149523275979 9.6831962882714e-07 6.013981264465121 -0.12573566341165177 S(ph)REDLSAQPVQTK ddPTM_A459_Selumetinib_30min_R1 5 SREDLSAQPVQTK 13 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 S(1)REDLSAQPVQTK;S(1)REDLSAQPVQTK;S(1)REDLSAQPVQTK;S(0.997)REDLS(0.003)AQPVQTK;S(1)REDLSAQPVQTK 142.4 0.00042754 780361700.0 16988.420000000002 21258.399999999998 20284.3 21971.100000000002 18249.7 17902.7 19097.5 17160.100000000002 10252.87 15322.1 True False 17384.21713228903 18769.456645237962 17529.803473684296 18134.25983362651 16599.01785724622 17722.615092351025 17656.960199514542 16704.958404139543 17398.37155000332 17288.840784892684 1.0055166421267347 1.0856399731345243 1.0139374693647576 1.0488996954308567 0.9601001052511721 1.0250898433767395 1.0212923133020884 0.9662277888947102 1.006335344658061 1.0 14.077553519209093 -6.2331322508958635 24.930205633221064 0.9974873009097942 1.0401113467293464 0.3502577767495868 0.027964437549701186 778.6982376917987 685802.2122694437 0.007948506823917867 0.01025916455460092 5.846120315987071e-07 6.2331322508958635 0.04262404581955215 S(ph)REDLSAQPVQTK ddPTM_A459_Selumetinib_30min_R2 4 SREDLSAQPVQTK 13 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 S(1)REDLSAQPVQTK;S(0.972)REDLS(0.028)AQPVQTK;S(0.987)REDLS(0.013)AQPVQTK;S(0.978)REDLS(0.022)AQPVQTK 168.55 0.00015231 667746400.0 2491712.0 2381764.0 2504475.0 2457069.0 2501783.0 2111928.0 2022901.0 2327994.0 1501654.0 2447945.0 True False 2353232.622153442 2564437.6402216703 2343339.8051662003 2122411.9635195546 2187486.6533162068 2402826.9118264127 2116969.9048022884 2334768.077119844 1802026.7597184158 2377266.4673250536 0.9898901341090908 1.0787337790984892 0.9857287087395683 0.8927951463126191 0.9201688928787227 1.0107520317358953 0.890505937764875 0.9821230010226706 0.7580247248202223 1.0 21.180872193068218 -5.548023079357921 5.175344731937158 0.9240759228298263 1.0345242295097103 0.29314584088614837 0.07094800910986998 0.20467701684422424 14.957884811617978 0.018393021612660033 0.033937674368351135 2.8312415334386876e-06 5.548023079357921 0.11044830667988403 S(ph)RESASPTIPNLDLLEAHTK ddPTM_A459_Selumetinib_30min_R1 1 SRESASPTIPNLDLLEAHTK 20 1 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 S(0.408)RES(0.137)AS(0.091)PT(0.364)IPNLDLLEAHTK 57.662 0.016196000000000002 7428700.0 1328.8 2164.3 2615.4 3909.4 2461.0 2634.7 1876.6 1594.7 1147.3 1397.3 True False 1359.7584546052938 1910.9027498442265 2260.243045363851 3226.696678526768 2238.4029845248406 2608.1973101161975 1735.0465511406726 1552.4033756843685 1946.8843045233978 1576.6570658545857 0.8624313327567351 1.2119964393198415 1.433566686322333 2.046543124948875 1.4197145549286414 1.6542578386901736 1.1004590590536796 0.9846170161568577 1.2348178603240776 1.0 10.622653182461532 -7.337439325249705 8.218754126298313 1.0766992163111972 1.4541620073323158 0.2669670396890319 0.2900234121309618 0.5065187179387153 50.391349900006524 0.13152056475008375 0.08846866401762872 4.597912209123363e-08 7.337439325249705 0.37746279102111857 S(ph)RESLNVDVVK ddPTM_A459_Selumetinib_30min_R1 4 SRESLNVDVVK 11 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9;H0YGB8 Q07866-6 KLC1 Kinesin light chain 1 1 S(0.992)RES(0.008)LNVDVVK;S(0.926)RES(0.074)LNVDVVK;S(0.977)RES(0.023)LNVDVVK;S(0.782)RES(0.218)LNVDVVK 123.72 0.0039049 111685800.0 12261.9 14287.8 13316.4 13961.7 12339.6 12024.3 14330.599999999999 13484.2 7408.5 11933.300000000001 True False 12547.57841249598 12614.97773378198 11508.106021749323 11523.551188567864 11223.48535873333 11903.346459190876 13249.63130436775 13126.555213145508 12571.683404568634 13465.05529518538 0.9318623754172433 0.9368678744522232 0.854664594349212 0.855811649929746 0.8335268673383349 0.8840176440602575 0.9840012546480474 0.9748608472361113 0.9336525642834764 1.0 13.71693253392865 -7.254557055499827 23.231311590727046 0.9710337397157628 0.880505624799311 0.6248363320661765 0.03424953795942345 150.54916064408314 508181.369846488 0.014729017151643368 0.01112679341850853 5.564715229297483e-08 7.254557055499827 -0.09052811491645174 S(ph)RESLNVDVVK ddPTM_A459_Selumetinib_30min_R2 3 SRESLNVDVVK 11 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9;H0YGB8 Q07866-6 KLC1 Kinesin light chain 1 1 S(0.963)RES(0.037)LNVDVVK;S(0.5)RES(0.5)LNVDVVK;S(0.914)RES(0.086)LNVDVVK 124.16 0.0020086 97424500.0 139309.0 134345.0 151184.0 170336.0 164636.0 137315.0 148009.0 145042.0 111316.2 149205.0 True False 131566.76347811226 144648.82951273982 141456.98603669327 147135.94295401036 143952.95381548576 156228.894828538 154891.71177426964 145464.04820700444 133582.55043449922 144897.06396885327 0.9080015831541869 0.9982868220423927 0.9762584704069679 1.0154515138114761 0.9934842699533895 1.0782060764331332 1.0689775729863291 1.0039130139881443 0.9219134382406383 1.0 17.144668836478033 -3.5300969307771894 0.9555125542447404 1.0150432745295603 1.6865256831221768e-11 0.3272511465536888 0.04196119471664396 22.693563048812766 2.4981275996648824 0.01451054987931358 40.75986909500224 0.00029505506157586096 3.5300969307771894 -1.0150432745126952 S(ph)REYEHVR ddPTM_A459_Selumetinib_30min_R2 1 SREYEHVR 8 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 S(0.997)REY(0.003)EHVR 65.627 0.046388 1573800.0 3789.0 3203.0 4409.6 6331.4 4829.1 5033.3 5299.8 3742.9 3480.0 6918.2 True False 3578.422548568773 3448.659800731737 4125.891136809469 5469.052397725797 4222.4252852982445 5726.591387251793 5546.251201354468 3753.791219329548 4176.097239324166 6718.453590357718 0.5326259235762977 0.513311546228619 0.6141132153879758 0.8140344089858634 0.6284817225437477 0.8523674846054694 0.8255249704060489 0.5587284586912925 0.6215860812550189 1.0 12.713913485782104 -5.550189360187347 4.417566850797036 0.7400195215472429 0.5292407868786135 0.37118824884084445 0.12368573042899612 0.2222171264685316 10.212302243819959 0.03389458952751678 0.06415174789742514 2.8171543335964697e-06 5.550189360187347 -0.2107787346686294 S(ph)RFSGGFGAR ddPTM_A459_Selumetinib_30min_R1 1 SRFSGGFGAR 10 1 A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y5G6 1 S(0.998)RFS(0.002)GGFGAR 70.399 0.040775 14753000.0 2205.6 2126.0 2760.0 2777.5 2465.3 1877.5 2151.4 2055.6 1285.7 1704.1 True False 2256.986188649485 1877.0869316494152 2385.207159594795 2292.46176513227 2242.3140502840665 1858.6140546336055 1989.1181658979228 2001.078810470173 2181.738996187338 1922.837834339653 1.1737787494828373 0.976206572455992 1.2404619448389054 1.192228343020697 1.166148288867079 0.9665994819952649 1.034470057939666 1.0406903664642058 1.134645344097152 1.0 10.909021380434426 -6.7433234860532805 24.999898632140724 1.0377735019070236 1.147520499057113 0.36495313660005735 0.07544403698407645 297.2548852452717 410210.2474740864 0.025614127154454776 0.02556712215681575 1.8058285460305963e-07 6.7433234860532805 0.10974699715008951 S(ph)RFSGGFGAR ddPTM_A459_Selumetinib_30min_R2 2 SRFSGGFGAR 10 1 A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4;A0A2R8YDT5;A0A0J9YVQ7 A0A2R8Y5G6 1 S(0.999)RFS(0.001)GGFGAR;S(0.926)RFS(0.074)GGFGAR 85.67200000000003 0.019872 25743000.0 32926.0 41286.0 37975.0 46263.0 47940.0 40117.0 37013.0 33985.0 33395.0 43497.0 True False 31096.10473322127 44452.50344458647 35531.72984405376 39961.89959187359 41917.348610962246 45642.75260413248 38734.17783986812 34083.89072348038 40074.93313426164 42241.12859122162 0.7361570528606458 1.0523512256210033 0.8411643113966851 0.9460424217969003 0.992334959053943 1.0805287199077767 0.9169778159743038 0.8068887328584198 0.9487183337849987 1.0 15.36636076043917 -4.742657400852769 24.908803055330033 0.9480923836638532 0.7361563278230371 0.393098061529074 0.08087391835636588 1393.680077649589 1848208.307348647 0.02088016769705259 0.7258380876479733 1.808600302514624e-05 4.742657400852769 -0.2119360558408161 S(ph)RFTPELQPK ddPTM_A459_Selumetinib_30min_R2 2 SRFTPELQPK 10 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 S(0.825)RFT(0.175)PELQPK;S(0.966)RFT(0.034)PELQPK 70.54 0.040546 8617100.0 52168.0 46549.0 59576.0 59174.0 63164.0 47432.0 54337.0 56061.0 45161.0 54351.0 True False 49268.711405050344 50119.158621374205 55742.945021444335 51114.39911915631 55228.77362667545 53965.327455173894 56863.77816672286 56224.12822860182 54194.46190376976 52781.74540914283 0.9334422540054168 0.949554779457759 1.0561027224345743 0.9684105503320907 1.0463612599121959 1.0224240793262218 1.0773379645924506 1.0652191925972705 1.0267652477892901 1.0 15.68775143865394 -4.289524944009207 0.6338232172710341 1.0439244750932668 0.7622111540648061 0.5336640186630301 0.0324661984145708 4.310544577800857 0.8374591794614937 0.014467843372293966 1.0127286795517128 5.134226878626923e-05 4.289524944009207 -0.2817133210284607 S(ph)RLSAIEIDIPVVSHTT ddPTM_A459_Selumetinib_30min_R2 1 SRLSAIEIDIPVVSHTT 17 1 P56749 P56749 CLDN12 Claudin-12 1 S(0.809)RLS(0.191)AIEIDIPVVSHTT 172.57 2.9298e-07 2161200.0 11532.0 4828.2 6892.3 11484.0 7993.7 5946.8 14284.0 11440.0 8294.9 9911.7 True False 10891.097606253641 5198.507414890096 6448.856921768842 9919.859388995017 6989.459941415295 6765.917720324425 14948.234303209047 11473.288506006054 9954.111778870694 9625.523467310653 1.1314810714701407 0.5400752938315307 0.6699746713692898 1.0305786924403604 0.726138164345272 0.7029142615777971 1.5529788435896406 1.1919651481782385 1.0341371887644306 1.0 13.232649285944786 -7.236969831177304 24.981007041919437 1.2107674418873564 0.7895569424011805 0.44916034533467386 0.21357830911889414 663.6120937006901 677483.8055181009 0.08059234203105202 0.06239775364977185 5.7946894858183324e-08 7.236969831177304 -0.42121049948617595 S(ph)RLSLQENQLPK ddPTM_A459_Selumetinib_30min_R2 2 SRLSLQENQLPK 12 1 Q5RGS4 Q5RGS4 PLEKHA1 1 S(0.691)RLS(0.309)LQENQLPK;S(1)RLSLQENQLPK 136.27 0.00078127 19318800.0 98801.0 94376.0 90506.0 105901.0 104973.0 96087.0 99011.0 91741.0 80579.0 110723.0 True False 93310.03595173996 101614.33573333092 84682.94249548222 91477.10111058527 91785.35326947311 109322.11205905922 103615.2076865746 92007.95112145982 96697.05156537401 107526.13929709702 0.8677893260346895 0.9450198472444765 0.7875568029230682 0.8507429143143704 0.8536096791857115 1.0167026620103963 0.963628084890908 0.855679853502783 0.8992887887306917 1.0 16.71432789192783 -6.7103691102065905 24.999252591262536 0.9390757314751768 0.8609707050176744 0.36619103534036246 0.05615831891399048 135.71706961674295 66433.86710079455 0.019531515654790537 0.019531491209298025 1.9481881159269952e-07 6.7103691102065905 -0.07810502645750239 S(ph)RLSSSSSNDSGNK ddPTM_A459_Selumetinib_30min_R2 1 SRLSSSSSNDSGNK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.674)RLS(0.325)S(0.001)SSSNDSGNK 102.33 0.0042142 2861000.0 5513.0 5514.0 4207.0 5142.0 5669.0 4940.4 6576.7 9138.6 5503.5 8749.4 True False 5206.609530287578 5936.9060696955385 3936.3262002352667 4441.650729555242 4956.8095384969765 5620.895255514024 6882.529581483821 9165.191813023328 6604.35378063809 8496.78208832872 0.6127742804466456 0.6987240590588456 0.46327258476385436 0.5227450443452405 0.5833749161704063 0.6615322362138664 0.8100160166444358 1.0786662194871095 0.7772770575945342 1.0 13.052700850124278 -7.305147518303669 2.232490473178805 0.947219074561631 0.5764003945595207 0.7591455042944308 0.09276336347395486 0.1506948527123449 1.4691364780220943 0.045841493376635845 0.02884205086341282 4.9528192810947915e-08 7.305147518303669 -0.37081868000211027 S(ph)RLTPVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R1 2 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 S(0.983)RLT(0.017)PVS(0.944)PES(0.027)S(0.022)S(0.005)T(0.001)EEK;S(0.909)RLT(0.091)PVS(0.386)PES(0.384)S(0.124)S(0.086)T(0.019)EEK 147.53 0.0022977 127740000.0 9343.3 10212.4 12100.5 10634.6 9277.0 9438.099999999999 8723.8 8402.8 5314.6 6719.9 True False 9560.980711102982 9016.72746038404 10457.318563288696 8777.466746165848 8437.896987987375 9343.161283109157 8065.756742428329 8179.930447858913 9018.488036973808 7582.464622369018 1.2609331117612006 1.1891552297895074 1.3791450516549164 1.1576007516436617 1.1128171917999785 1.2322063799079142 1.0637381305589677 1.0787957287301166 1.1893874203340664 1.0 12.88845114632105 -6.334272541879116 0.188055561957667 0.9717644654652807 1.4073122841685934 0.4934549135032442 0.0741095265512168 7.003479900755809 0.4867830934618084 0.26280098142385205 0.8225663181949894 4.6315617445777114e-07 6.334272541879116 0.4355478187033127 S(ph)RLTPVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R2 1 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 S(0.791)RLT(0.209)PVS(0.98)PES(0.014)S(0.002)S(0.003)TEEK 120.32 0.0031837 15195000.0 69011.0 72318.0 89677.0 106430.0 105420.0 86040.0 77183.0 78641.0 79930.0 100580.0 True False 65175.64489292144 77864.55806097963 83907.27945293512 91934.05039800954 92176.19713324249 97891.22900664443 80772.16243521307 78869.83229028151 95918.23343079888 97675.99406177597 0.6672636968680409 0.7971719029727362 0.8590368622188507 0.941214382111792 0.9436934634619117 1.0022035603214063 0.8269397533249374 0.8074638302672369 0.9820041695212707 1.0 16.57571641253528 -4.898850042328829 1.3855809619920674 0.9197959672653344 0.5992322121134257 0.6238612942926909 0.06376664249709288 0.7239729416117693 1.476802497506985 0.019770914706155007 0.30752788646884066 1.2622633066259886e-05 4.898850042328829 -0.3205637551519087 S(ph)RLTPVSPES(ph)SSTEEK ddPTM_A459_Selumetinib_30min_R2 1 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 S(0.996)RLT(0.005)PVS(0.048)PES(0.664)S(0.08)S(0.033)T(0.175)EEK 128.72 0.031958999999999994 10661000.0 27082.0 23135.0 27634.0 28658.0 27728.0 23351.0 22223.0 26208.0 18031.0 25472.0 True False 25576.890857835686 24909.38010925031 25856.058525624285 24754.730962192545 24244.56074853488 26567.38829072706 23256.413534039082 26284.260941032033 21637.703828233927 24736.557175795988 1.0339713273786515 1.006986539485916 1.0452569588351486 1.0007346934445 0.9801105536326409 1.074013174182642 0.9401637167517723 1.0625674686350626 0.8747257621366081 1.0 14.594357100112783 -8.25425392759481 24.99876502945814 0.9373628791504305 1.0159559635591136 0.3210957168799541 0.046813130582939656 553.6741689258149 1926293.917778923 0.030031794627119416 0.010836199912365852 5.568600632769984e-09 8.25425392759481 0.07859308440868307 S(ph)RLTPVSPESSSTEEK ddPTM_A459_Selumetinib_30min_R2 4 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.758)RLT(0.242)PVSPESSSTEEK;S(0.758)RLT(0.242)PVSPESSSTEEK;S(0.633)RLT(0.367)PVSPESSSTEEK;S(0.638)RLT(0.362)PVSPESSSTEEK 141.3 0.0002185 454747700.0 279870.0 258770.0 263758.0 260083.0 252785.0 265644.0 246401.0 237145.0 192838.0 277536.0 True False 264315.9458083771 278616.8269233067 246788.09743799685 224659.24673179977 221027.88837342712 302234.04972386174 257859.13473431865 237835.05268853199 231410.9883439064 269522.8145548719 0.9806811577153715 1.0337411598474657 0.9156482646768795 0.8335444518967118 0.8200711644335708 1.121367221632105 0.9567247031023467 0.8824301314949031 0.8585951757964952 1.0 18.040047873767335 -5.270674635009151 23.854319414286895 0.9206886023584131 1.0072111581121923 0.13339633505874038 0.08504773479448723 654.4702923958581 1690479.5771741138 0.023635937396984594 0.050395503374980034 5.361982163640174e-06 5.270674635009151 0.0865225557537792 S(ph)RNSPLLER ddPTM_A459_Selumetinib_30min_R2 1 SRNSPLLER 9 1 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 S(0.925)RNS(0.075)PLLER 75.73899999999998 0.032070999999999995 72684000.0 28533.0 21525.0 29196.0 29627.0 35495.0 20018.0 23440.0 28187.0 21886.0 22020.0 True False 26947.250086648924 23175.898286216256 27317.56114620129 25591.751490574316 31035.800770673894 22775.297794688635 24530.006445478848 28269.01950339096 26263.81154593354 21384.2253851691 1.2601461872609157 1.0837847931723428 1.2774632073017347 1.1967584062373062 1.4513408931893594 1.065051335012785 1.147107552583667 1.3219566757370957 1.2281862481747245 1.0 14.384259328020864 S(ph)RNTDEMVELR ddPTM_A459_Selumetinib_30min_R2 3 SRNTDEMVELR 11 1 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 S(0.995)RNT(0.005)DEMVELR;S(0.553)RNT(0.447)DEMVELR;S(0.999)RNT(0.001)DEMVELR 117.48 0.0030724 20915100.0 35831.0 36818.0 37203.0 40151.0 40137.6 32427.2 31325.4 31034.6 31866.7 37932.0 True False 33839.65646285764 39641.82221147083 34809.39948356374 34682.36453566168 35095.15585330328 36893.752455186695 32782.09317010253 31124.90554794538 38240.93042999179 36836.804600828065 0.918637130162396 1.076147147968956 0.9449625140064741 0.9415139263974609 0.9527198744191391 1.0015459498991763 0.8899277102163637 0.8449404307789963 1.038117470947308 1.0 15.168860300194787 S(ph)RPALSPLGDIDFCPPNPGPDGPR ddPTM_A459_Selumetinib_30min_R1 2 SRPALSPLGDIDFCPPNPGPDGPR 24 1 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 S(0.789)RPALS(0.211)PLGDIDFCPPNPGPDGPR;S(0.771)RPALS(0.229)PLGDIDFCPPNPGPDGPR 88.47 0.0011113 13891000.0 3409.8999999999996 4606.5 4615.3 4988.3 4203.4 3806.6000000000004 4023.3 3781.3 2492.43 3356.5 True False 3489.3440354896084 4067.1688384962495 3988.5676100282085 4117.1870469880505 3823.2032121705442 3768.309060116264 3719.819241822589 3681.007640606572 4229.47167011527 3787.3394700786616 0.9213180025336192 1.0738854730684535 1.0531317938461342 1.0870921604771113 1.0094693761610807 0.9949752563474321 0.9821721214088395 0.971924399618215 1.1167395221710679 1.0 11.886969024566604 -6.46015722514241 24.999769068968455 1.0086648842177297 1.0393663351621698 0.02706423662356494 0.05620370554995122 700.6346510608081 279260.9696739922 0.017287811749734816 0.019602517598153964 3.466113460168531e-07 6.46015722514241 0.0307014509444401 S(ph)RPALSPLGDIDFCPPNPGPDGPR ddPTM_A459_Selumetinib_30min_R2 2 SRPALSPLGDIDFCPPNPGPDGPR 24 1 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 S(0.708)RPALS(0.292)PLGDIDFCPPNPGPDGPR;S(0.777)RPALS(0.223)PLGDIDFCPPNPGPDGPR 73.166 0.00039984 12601300.0 48153.0 45181.0 45927.0 52706.0 52490.0 45849.0 38851.0 41283.0 39524.0 47407.0 True False 45476.849031731836 48646.23742018751 42972.106821536756 45527.35187707867 45895.736933446184 52164.28357421717 40657.64848179604 41403.12669523144 47429.90439282997 46038.23673182163 0.9878060555759347 1.0566485789531386 0.9334003617874105 0.9889030316751937 0.9969047511700867 1.1330643238593283 0.8831278382495799 0.8993204265491255 1.0302285178538653 1.0 15.490544958741333 -7.309407717642298 24.99996181852205 0.9447792775072023 1.0120930430912671 0.18441080226660744 0.06355190770038584 672.1336733396801 350297.4850080215 0.026675541358681606 0.017984731234463442 4.904472258614577e-08 7.309407717642298 0.06731376558406488 S(ph)RPTSFADELAAR ddPTM_A459_Selumetinib_30min_R2 2 SRPTSFADELAAR 13 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 S(0.969)RPT(0.026)S(0.005)FADELAAR;S(0.619)RPT(0.364)S(0.018)FADELAAR 115.58 0.0021866 18551000.0 15411.6 17194.0 14557.5 15039.8 17943.1 15977.8 12433.5 17130.9 18229.0 19673.4 True False 14555.084969522952 18512.724512576173 13620.886299007572 12991.353294897888 15688.92736465075 18178.596917972638 13011.682386512857 17180.748082826827 21875.30936081617 19105.377824368104 0.7618318309810421 0.9689797648997013 0.7129346733794872 0.6799841078425555 0.8211785974020458 0.9514910976943154 0.6810481585931791 0.8992624087712888 1.1449817722481852 1.0 14.221691167993495 -8.05706137981931 5.123553610724022 1.0644796022880845 0.8014747195395363 0.5420741381310069 0.10031595613204529 0.16688161211447003 9.14115526755469 0.06976424326761937 0.026038882909601123 8.768768813967818e-09 8.05706137981931 -0.26300488274854816 S(ph)RS(ph)PESQVIGENTK ddPTM_A459_Selumetinib_30min_R2 2 SRSPESQVIGENTK 14 1 O95218-2 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 2 S(0.876)RS(0.616)PES(0.508)QVIGENTK;S(0.984)RS(0.931)PES(0.085)QVIGENTK 111.78 0.029042 7397200.0 63584.0 53491.0 58092.0 56409.0 56172.0 45668.0 52843.0 54623.0 41252.0 48804.0 True False 60050.25582691916 57593.58769932608 54354.42396578728 48725.996889047354 49115.17117594851 51958.3524671716 55300.30420641801 54781.94388667558 49503.55267718404 47394.901711979684 1.2670193134241834 1.2151852967081593 1.146841158065921 1.0280851975420642 1.0362965087346938 1.0962856887629844 1.1667985840012858 1.1558615359007849 1.044491092692178 1.0 15.532444255752422 -5.310057021384639 2.458209758671584 1.08520715221807 1.2541486396594674 0.6089924207561628 0.05261645214131842 0.2252445322725487 2.594263452228358 0.015589372460426718 0.04814120735983099 4.8971451730089865e-06 5.310057021384639 0.16894148744139748 S(ph)RS(ph)PLAIR ddPTM_A459_Selumetinib_30min_R2 2 SRSPLAIR 8 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(1)RS(1)PLAIR;S(1)RS(1)PLAIR 95.483 0.026783 47420000.0 1790.4 1752.54 2081.3 1478.94 2864.4399999999996 1380.99 960.91 1233.97 1494.9499999999998 2732.09 True False 1690.8967355390675 1886.9541826957222 1947.3914239481016 1277.5058206861972 2504.583438781491 1571.208837120944 1005.5942190070429 1237.5606484052698 1793.9817723930068 2653.2074628776877 0.6373028717871572 0.711197374912069 0.7339763102565477 0.4814948844221195 0.9439832632104095 0.5921922273717712 0.3790107758540556 0.4664394570423086 0.6761558594619818 1.0 11.373521773633394 -8.557934360980326 21.576992517360715 1.000000003881984 0.6194138022394251 0.3625631298697407 0.15105348512703254 2818.504240956601 1734808.7292890141 0.1539203247229462 0.03974205701274039 2.767359870994109e-09 8.557934360980326 -0.38058620164255896 S(ph)RS(ph)PPPVSK ddPTM_A459_Selumetinib_30min_R2 1 SRSPPPVSK 9 1 Q01130-2;Q01130 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 2 S(1)RS(1)PPPVSK 99.669 0.0367 25262000.0 261530.0 160700.0 214070.0 248190.0 271900.0 206750.0 326220.0 346960.0 253110.0 184430.0 True False 246995.20958754045 173025.17326805828 200296.9692617929 214386.0938483698 237741.4911831588 235227.9358103643 341389.87639266666 347969.59615768015 303739.0724842934 179105.02669331245 1.3790523590969819 0.9660542557766125 1.11832131660251 1.1969853543835502 1.3273859230665341 1.3133519485924479 1.9060876330246164 1.942824289088883 1.6958712889973548 1.0 17.45044630245721 -7.092559111090063 4.193683145938513 1.7127215006075402 1.1895684296077107 0.36315469925436805 0.2668361940107707 0.20870436415109594 6.486085392263524 0.10155779528314092 0.07862014003794628 8.080549386314268e-08 7.092559111090063 -0.5231530709998296 S(ph)RS(ph)RS(ph)KS(ph)AER ddPTM_A459_Selumetinib_30min_R1 1 SRSRSKSAER 10 3 Q9BUQ8;F8W1J5;F8VVA2;Q9BUQ8-2 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 4 S(1)RS(1)RS(1)KS(1)AER 56.01300000000001 0.047481 0.0 1818.1 1921.4 1779.0 2213.1 1902.8 1361.2 1703.3 1467.0 727.63 874.85 True False 1860.4581925932314 1696.441594765375 1537.421571347514 1826.6236300321254 1730.6920759666248 1347.507563870713 1574.8187096653032 1428.0903945124264 1234.7349660074606 987.1455192606339 1.8846848375371277 1.7185324368751624 1.5574416753661946 1.8504096856968522 1.7532289233940936 1.3650546323504442 1.5953257943619428 1.4466868021465138 1.2508135243649483 1.0 9.947118963859486 -8.128144567278515 0.38854242512449083 0.9561115260747307 1.8093166279715347 0.8018081975194256 0.11865394022702276 0.5191995358402044 0.2322548116611146 0.16750300818681038 0.11888847346159737 7.444841099296511e-09 8.128144567278515 0.853205101896804 S(ph)RSAPPNLWAAQR ddPTM_A459_Selumetinib_30min_R2 1 SRSAPPNLWAAQR 13 1 Q92934;F5H3B1;F5H1R6 Q92934 BAD Bcl2-associated agonist of cell death 1 S(0.758)RS(0.242)APPNLWAAQR 155.47 0.00020103 10637000.0 8058.7 7296.0 7322.7 9315.2 8002.5 6653.5 6159.1 6797.7 4909.0 6705.4 True False 7610.829715532105 7855.579739662427 6851.565454352929 8046.4536903837 6997.154406742292 7569.959230540554 6445.510354025122 6817.480181580181 5890.93716892021 6511.797679278511 1.1687755195083647 1.2063611504178064 1.0521772622260068 1.2356731714790046 1.0745349827142598 1.1624991443805552 0.9898204261682876 1.0469428746649172 0.9046560503048229 1.0 12.668840160612076 -7.358305713597179 1.2872760159181615 0.9661790920649227 1.1563496284644825 0.6181354803685465 0.06237683083001374 0.2939180383581363 0.9368291673054611 0.03927165090535855 0.02086329436655091 4.3822211079651125e-08 7.358305713597179 0.19017053639955983 S(ph)RSDIDVNAAASAK ddPTM_A459_Selumetinib_30min_R2 1 SRSDIDVNAAASAK 14 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.913)RS(0.087)DIDVNAAASAK 185.99 0.00038689 52388000.0 141420.0 115580.0 131850.0 153600.0 146720.0 117640.0 109640.0 118950.0 99499.0 129460.0 True False 133560.44254911467 124444.61435172458 123366.91454742575 132679.41502522095 128287.72190655794 133843.8421704052 114738.47724753848 119296.12480676753 119401.5802343434 125722.15342252482 1.0623461252707553 0.9898383933457876 0.9812663177412845 1.055338390357619 1.0204066539920837 1.0646002993647838 0.9126353162431716 0.9488870621380402 0.9497258596347826 1.0 16.939879362992116 -7.2627230956580595 24.99999340220326 0.9485526478401825 1.0258290134715453 0.5571980251621529 0.03310053221653917 88.6590890125887 1726582.1724869686 0.013306596161378291 0.009522414665408645 5.4610594497336336e-08 7.2627230956580595 0.07727636563136286 S(ph)RSDVDMDPSSATAVLGPAR ddPTM_A459_Selumetinib_30min_R2 2 SRSDVDMDPSSATAVLGPAR 20 1 M0QZR4;M0QYC1;M0QZH8;M0QYS3 M0QZR4 ARHGEF1 1 S(0.505)RS(0.488)DVDMDPS(0.002)S(0.004)AT(0.001)AVLGPAR;S(0.5)RS(0.5)DVDMDPSSATAVLGPAR 98.804 0.004063300000000001 27965800.0 44215.0 38575.0 44699.0 45945.0 51630.0 42077.0 34302.0 32506.1 35768.0 43669.0 True False 41757.70730666883 41533.578461825404 41823.115004591455 39687.21174045419 45143.77782194373 47872.72481302399 35897.11096812354 32600.687369325464 42922.59944142147 42408.162504311964 0.984662028269275 0.9793769880409783 0.9862043657359353 0.9358389846864714 1.064506810861084 1.1288563801404128 0.8464670206938016 0.7687361452175793 1.0121306113429744 1.0 15.37205435356262 -7.288066002124183 24.994158101913413 0.8875614496154653 1.0092847389260053 0.2713091122266361 0.08291122516386694 926.7985741422721 869973.0398245088 0.03517344608504981 0.02372235260612507 5.151503483968482e-08 7.288066002124183 0.12172328931054 S(ph)RSFDYNYR ddPTM_A459_Selumetinib_30min_R2 1 SRSFDYNYR 9 1 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.997)RS(0.003)FDYNYR 89.029 0.016725 7202200.0 30458.0 33247.0 34190.0 37101.0 36130.0 22893.0 19158.0 24597.0 22501.0 34672.0 True False 28765.26629303448 35796.93799404562 31990.25262325736 32047.77979720516 31591.026393701864 26046.30294803712 20048.884960856813 24668.573197747446 27001.82873046926 33670.9292713253 0.8543056849200606 1.0631407795605707 0.9500852312532035 0.9517937428741403 0.9382285276161144 0.773554621500113 0.5954360451207018 0.7326371362953619 0.8019329823921565 1.0 15.039215917662807 -6.760168360223655 4.451167032838594 0.7502215810606563 0.9598257788206531 0.38200171000546734 0.1055423373026467 0.17459062654942456 8.36746550983992 0.0358634568357285 0.033587289387192694 1.7371272769428139e-07 6.760168360223655 0.20960419775999684 S(ph)RSFTLDDESLK ddPTM_A459_Selumetinib_30min_R2 1 SRSFTLDDESLK 12 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 S(0.995)RS(0.005)FTLDDESLK 189.33 7.1002e-05 40099000.0 205910.0 222040.0 215780.0 209940.0 208840.0 164260.0 182330.0 195540.0 176290.0 283200.0 True False 194466.3465230394 239069.75402887195 201896.9497235002 181345.80983329972 182603.65214671192 186885.32399618102 190808.70628004096 196108.9890266103 211552.92595415478 275023.28015803307 0.7070904921623207 0.8692709718664485 0.7341085802172339 0.6593834882963192 0.6639570731677141 0.6795254710393736 0.6937911080487406 0.7130632320068422 0.7692182488427629 1.0 18.069194219426855 -8.786541925727606 2.3235387165679415 0.9999503869945575 0.7154687313841991 0.6960468580835752 0.05630011331330771 0.8153746594742666 6.298405130570693 0.06016369918434131 0.016351568525425294 1.6347753262983118e-09 8.786541925727606 -0.28448165561035843 S(ph)RSGDVLAK ddPTM_A459_Selumetinib_30min_R2 1 SRSGDVLAK 9 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3;B1AHG4 P85299 PRR5 Proline-rich protein 5 1 S(0.808)RS(0.192)GDVLAK 85.973 0.018952 5417200.0 62256.0 43127.0 61502.0 64507.0 67484.0 34494.0 45885.0 58112.0 41667.0 44929.0 True False 58796.06075051396 46434.70222483851 57545.028278314545 55721.03531921822 59006.05660538542 39245.23539464432 48018.74341940259 58281.09629904047 50001.56427325286 43631.783030438804 1.3475511809704435 1.0642403083193805 1.318878676999504 1.2770744500710778 1.3523640911997814 0.8994643965676511 1.100545063352174 1.3357486733554271 1.1459894783206614 1.0 15.413091810784161 -6.712786345893949 24.999999714063712 1.1175927946326278 1.2633621229378433 0.3072404106855826 0.12962494986327333 180.60105559678993 92799.79478176608 0.04426540218880414 0.04426530805543141 1.9373748341875637e-07 6.712786345893949 0.1457693283052155 S(ph)RSLGPGAGPR ddPTM_A459_Selumetinib_30min_R1 1 SRSLGPGAGPR 11 1 H3BUV2;P78549-3;P78549-2;P78549 H3BUV2 NTHL1 Endonuclease III-like protein 1 1 S(1)RSLGPGAGPR 78.556 0.026043 6936200.0 1142.6 1271.2 1493.1 2269.7 1505.1 1282.3 1183.6 1337.9 575.25 1050.1 True False 1169.2203568874247 1122.3673130351526 1290.3452210112266 1873.339502545713 1368.9639707469876 1269.4012262352455 1094.3200990781736 1302.414545888328 976.1572354023224 1184.8905638401911 0.9867749753175687 0.94723288992833 1.0889994910831768 1.581023226714104 1.155350555168758 1.0713236014988237 0.9235621689242914 1.0991855160591755 0.8238374624561352 1.0 10.210538103029638 -6.998067742471541 3.5440146943502766 0.9707640330215422 1.1595081591040977 0.21000779514487844 0.17292664058785823 0.4318989027697564 11.633504195277675 0.07335172940871908 0.06004439065902582 1.0044590997101817e-07 6.998067742471541 0.18874412608255542 S(ph)RSLGPGAGPR ddPTM_A459_Selumetinib_30min_R2 3 SRSLGPGAGPR 11 1 H3BUV2;P78549-3;P78549-2;P78549 H3BUV2 NTHL1 Endonuclease III-like protein 1 1 S(0.999)RS(0.001)LGPGAGPR;S(0.999)RS(0.001)LGPGAGPR;S(0.997)RS(0.003)LGPGAGPR 109.15 0.0052599 14016400.0 26079.7 30886.5 32372.0 33635.3 29295.8 20236.1 22991.1 23665.1 17511.7 27782.3 True False 24630.294679310886 33255.395234249394 30289.220763968613 29054.11411587113 25615.399696225057 23023.43908997396 24060.231706000366 23733.96152303179 21014.529317779587 26980.15281191569 0.9129041948358796 1.2325873565683536 1.1226482286857724 1.0768698872246372 0.9494164052663224 0.8533472456763009 0.8917752198710398 0.8796822497072652 0.7788884467881365 1.0 14.719610899087247 -6.3643830051777766 2.5022390639445034 0.8742221275080442 1.1037198615445534 0.5395428857304365 0.08916572210222998 0.20525922436089086 2.5120968247383413 0.029032350045230654 0.034336509254529995 4.3213256436145143e-07 6.3643830051777766 0.2294977340365092 S(ph)RSPFSTTR ddPTM_A459_Selumetinib_30min_R1 1 SRSPFSTTR 9 1 Q8NG27-3;Q8NG27;K7EPI8;Q8NG27-2 Q8NG27-3 PJA1 E3 ubiquitin-protein ligase Praja-1 1 S(0.995)RS(0.005)PFSTTR 72.289 0.03732 5086000.0 707.4 574.31 752.26 879.8 697.07 736.76 636.32 652.8 533.14 655.25 True False 723.8810436392123 507.06951821052473 650.1072238683986 726.1594458914026 634.0201415777043 729.3488633245564 588.3218700958291 635.485623406757 904.699640995036 739.3577201754931 0.9790674038913028 0.6858243369531156 0.8792864483975225 0.9821490005122855 0.8575282630811158 0.9864627681867432 0.7957201961131692 0.8595103642874234 1.2236291260748553 1.0 9.530128735819286 -8.24628838504036 24.671443878690447 1.1118145598751814 0.875453900382887 0.4602134949825335 0.10117046340783072 494.3338095915903 804963.1159214312 0.06673419875638005 0.024991339908568628 5.671678632408703e-09 8.24628838504036 -0.23636065949229446 S(ph)RSPGSPVGEGTGSPPK ddPTM_A459_Selumetinib_30min_R1 4 SRSPGSPVGEGTGSPPK 17 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.883)RS(0.083)PGS(0.033)PVGEGTGSPPK;S(0.978)RS(0.013)PGSPVGEGTGS(0.008)PPK;S(0.971)RS(0.027)PGS(0.002)PVGEGTGSPPK;S(0.581)RS(0.253)PGS(0.166)PVGEGTGSPPK 195.48 3.0381e-07 63995000.0 10253.9 9599.1 10783.900000000001 12424.7 10574.2 9805.3 8872.2 8727.0 5477.39 7482.200000000001 True False 10492.795919383825 8475.232909499482 9319.505611722578 10254.95938550456 9617.765477026645 9706.667584500072 8202.962810950798 8495.531610708898 9294.730777262634 8442.613252799809 1.242837449163518 1.003863691930796 1.1038650394925962 1.2146664875480027 1.1391929476145461 1.1497231122462073 0.9716141869024337 1.0062680068747127 1.1009305411662957 1.0 13.043473911948645 -7.250126340141231 24.612488620727458 1.0202255174558454 1.1374561126537086 0.4404995892040785 0.067583806642689 603.5922312358342 1313169.1356191696 0.026220898600250106 0.020126826715015003 5.621777588720846e-08 7.250126340141231 0.11723059519786316 S(ph)RSPGSPVGEGTGSPPK ddPTM_A459_Selumetinib_30min_R2 3 SRSPGSPVGEGTGSPPK 17 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.938)RS(0.049)PGS(0.013)PVGEGTGSPPK;S(0.898)RS(0.101)PGS(0.001)PVGEGTGSPPK;S(0.755)RS(0.245)PGSPVGEGTGSPPK 179.85 4.3945e-08 79424000.0 171473.1 182433.6 197851.3 201006.1 206232.1 138866.5 123442.4 133939.8 102326.3 174148.0 True False 161943.31156320617 196425.67050351977 185121.76276220768 173628.72242513677 180323.37985963357 157994.09987042312 129182.71619647526 134329.54264307258 122794.4192357057 169119.89474915634 0.9575651155850428 1.1614580933536185 1.0946184837495658 1.0266605397470714 1.066245814113677 0.9342135654989892 0.7638528653774466 0.7942858694555963 0.7260790897359417 1.0 17.36768685841694 -6.973428909862886 2.8416803162549815 0.8045092912942976 1.0677002505445177 0.6429132292530058 0.0838302532365591 0.1512917967419845 2.486973983566655 0.031958036935802236 0.026207860532808797 1.0630925878182517e-07 6.973428909862886 0.26319095925022007 S(ph)RSPLELEPEAK ddPTM_A459_Selumetinib_30min_R2 1 SRSPLELEPEAK 12 1 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 S(0.5)RS(0.5)PLELEPEAK 85.28 0.017309 119010000.0 113940.0 138840.0 169140.0 195160.0 209680.0 164580.0 125040.0 152410.0 158870.0 171160.0 True False 107607.67093795887 149488.58155903674 158257.7165457075 168578.87133022153 183338.12383701655 187249.40109151046 130854.60776205956 152853.48786716632 190648.43919868695 166218.1660729131 0.6473881494442418 0.8993516478425242 0.9521084264417062 1.0142024503884424 1.1029969116407747 1.1265278971335289 0.7872461287092952 0.9195955621367868 1.1469771548018242 1.0 17.342718538079986 -4.520389839500513 1.3799359262542141 1.0072515600289185 0.2849093145201746 0.5436875840063997 0.1003352165882554 1.9526672240890866 2.11658234707243 0.030753065225304858 2.3350089164182894 3.017242111406354e-05 4.520389839500513 -0.7223422455087438 S(ph)RSPLGFYVHLK ddPTM_A459_Selumetinib_30min_R1 1 SRSPLGFYVHLK 12 1 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(0.5)RS(0.5)PLGFYVHLK 102.5 0.0063526 3807600.0 1481.5 1706.4 1438.5 1647.7 1271.0 1342.6 1445.2 1405.2 809.15 1389.4 True False 1516.016067502817 1506.6138947161617 1243.1596011148954 1359.9601261596554 1156.0382744132753 1329.094662983265 1336.1874004628046 1367.9295312671175 1373.068452022232 1567.7430239020696 0.9670054622405491 0.9610081956966652 0.7929613349646456 0.8674636757590232 0.7373901569250345 0.8477758425454094 0.8523000135169287 0.8725470376276198 0.8758249477677165 1.0 10.614473384596609 -10.596068894281998 17.56434624573585 0.9999999996189264 0.8604198143480927 0.2840005629467719 0.06467245990184049 0.0 0.0 0.06655220031635253 0.016141279501269805 2.5347265023993026e-11 10.596068894281998 -0.1395801852708337 S(ph)RSPLHPMSEIPR ddPTM_A459_Selumetinib_30min_R1 1 SRSPLHPMSEIPR 13 1 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 S(0.97)RS(0.03)PLHPMSEIPR 85.536 0.015219 25482000.0 2563.2 3206.1 2826.5 3108.1 3349.1 2966.6 2975.3 2773.3 1441.1 2186.0 True False 2622.917572881012 2830.7283215245466 2442.676824853147 2565.3286812628667 3046.1744963316296 2936.758697457287 2750.870725572228 2699.7430750520216 2445.441446220403 2466.594393443158 1.0633761188517257 1.147626188176439 0.9903034042996327 1.0400285868167745 1.234971791239429 1.1906127352206535 1.1152505385095943 1.0945225052925738 0.9914242295859487 1.0 11.268304783162774 -8.209099610778374 3.930422489714681 0.9935476823375263 1.1129153898679096 0.3168791829354337 0.06713564666764323 0.28972478965912823 8.929870787800972 0.059517786874965964 0.019078858358748615 6.178746667343012e-09 8.209099610778374 0.11936770753038328 S(ph)RSPLHPMSEIPR ddPTM_A459_Selumetinib_30min_R2 2 SRSPLHPMSEIPR 13 1 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 S(0.996)RS(0.004)PLHPMSEIPR;S(0.788)RS(0.212)PLHPMSEIPR 98.508 0.0068738 22547000.0 48700.0 52028.0 58218.0 61170.0 61945.0 48289.0 45687.0 50415.0 41088.0 54107.0 True False 45993.44896154636 56018.38030361254 54472.317262965684 52838.540475864305 54162.91530467368 54940.371426102494 47811.536027073045 50561.69930334744 49306.748094641174 52544.790323131005 0.8753189170363738 1.0661072193669485 1.036683502360198 1.0055904714992077 1.030795155363487 1.0455912201426545 0.909919627294158 0.9622590363842298 0.9383755799846746 1.0 15.681260111433083 -7.256870028864016 24.998109982234567 0.9494934804641794 1.0145198092303207 0.21508875774732972 0.05314414294131576 552.2201595246394 3021107.8555651763 0.02007573763063274 0.015029053079356737 5.535157348638367e-08 7.256870028864016 0.06502632876614134 S(ph)RSPLLVTVVESDPRPQGQPR ddPTM_A459_Selumetinib_30min_R1 1 SRSPLLVTVVESDPRPQGQPR 21 2 A0A2R8YH03;Q5VWN6;Q5VWN6-2 A0A2R8YH03 FAM208B Protein FAM208B 1 S(0.5)RS(0.5)PLLVTVVESDPRPQGQPR 87.79299999999998 0.00036394 9292300.0 2662.0 2848.9 3143.3 3872.4 3734.6 3071.5 3185.8 3438.2 2363.6 3429.4 True False 2724.0194206496776 2515.3494635823204 2716.457124910985 3196.158033950751 3396.8060893971815 3040.6034986988666 2945.4925410977053 3347.0077671524396 4010.8565694861854 3869.5968951847954 0.7039543121505399 0.6500288096448346 0.7020000270031379 0.8259666628138836 0.8778191065906787 0.7857675052619817 0.7611884702416893 0.864949982598278 1.036505010244651 1.0 11.917967569996144 -6.138026907322152 0.20371652183914982 1.0573598964360014 0.48845351442350354 0.7129324849898514 0.06464581367087503 4.577860809957159 0.3220648939556721 0.19108011463206914 0.7110133531280484 7.277347153177556e-07 6.138026907322152 -0.5689063820124978 S(ph)RSPPRPK ddPTM_A459_Selumetinib_30min_R2 1 SRSPPRPK 8 2 Q8WUQ7-2;Q8WUQ7 Q8WUQ7-2 CACTIN Cactin 1 S(0.983)RS(0.017)PPRPK 57.047 0.042256 6833200.0 14672.0 15713.0 14221.0 13391.0 12911.0 13491.0 18518.0 28245.0 17419.0 23318.0 True False 13856.588976669567 16918.136574741748 13306.036342654073 11567.122699236535 11289.004754195535 15349.262790895411 19379.12369272087 28327.18827378853 20903.286727525192 22644.748752560095 0.6119118003065949 0.7471108096453961 0.5875992040384093 0.5108081712732104 0.49852638585443615 0.6778287963632232 0.8557888587980014 1.2509385104388058 0.9230964298140856 1.0 14.466888912072982 -7.392096891605549 2.7660600851889003 1.0647718980798022 0.5981028169458366 0.7908241716797639 0.10459669342655509 0.11971474170295769 1.769972741786924 0.0513152855988739 0.031477486511387646 4.054180761122368e-08 7.392096891605549 -0.46666908113396566 S(ph)RSPQAFR ddPTM_A459_Selumetinib_30min_R1 2 SRSPQAFR 8 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;H3BSK8 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 S(0.894)RS(0.106)PQAFR;S(0.987)RS(0.013)PQAFR 82.241 0.022984 34311000.0 3112.1 3432.8 3562.8 4336.6 3586.4 3275.7 3691.3 3329.2 1725.24 2256.37 True False 3184.605874907539 3030.8861801345765 3078.9913290595396 3579.2942180639475 3262.010753230347 3242.7494320976293 3412.862269117321 3240.8988012343348 2927.6062734558936 2545.9970684050036 1.250828571025263 1.1904515593308764 1.209345983649715 1.4058516651420483 1.281231150542489 1.273665815384902 1.3404816177794676 1.272938936754027 1.149885956188456 1.0 11.314015042707329 -8.529607773450667 2.4515093848204863 1.0010979208575972 1.2795826045479133 0.6964162674227772 0.057968712958048084 0.17132705597109493 2.4401230803173366 0.05994685141893959 0.016318270913209573 2.9538757709712533e-09 8.529607773450667 0.2784846836903161 S(ph)RSPSLNR ddPTM_A459_Selumetinib_30min_R2 1 SRSPSLNR 8 1 Q9UPX8;Q9UPX8-3;A0A2R8Y2H5;A0A087X158 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 S(0.982)RS(0.017)PS(0.001)LNR 67.704 0.043302 2350400.0 2974.8 2186.1 888.96 3329.4 2572.9 1111.6 2078.1 2255.5 2003.8 2358.3 True False 2809.4725250679276 2353.7668405805966 831.7652814264661 2875.9299764646485 2249.669299982162 1264.7128098998844 2174.7357676770293 2262.0631315818746 2404.6159908499326 2290.2097514007405 1.2267315355502242 1.0277516455167406 0.3631830145329444 1.255749598789224 0.9822983674775714 0.5522257553599007 0.9495792978555415 0.9877100253364781 1.049954480972417 1.0 11.161264019861132 -7.6845462127476685 4.251174345417835 1.0154694703602942 0.892070163954894 0.03343074984408945 0.2587261826013057 0.8654142221397709 29.5197744216045 0.135325263795287 0.07263098366479237 2.067539365864265e-08 7.6845462127476685 -0.1233993064054002 S(ph)RSPSSPELNNK ddPTM_A459_Selumetinib_30min_R1 1 SRSPSSPELNNK 12 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.595)RS(0.11)PS(0.251)S(0.044)PELNNK 117.27 0.022824 4030100.0 1004.5 1304.4 1200.3 1170.3 1348.6 1276.6 1337.8 873.11 656.11 1154.7 True False 1027.9028955832462 1151.6802416008918 1037.3058527759538 965.9290742517718 1226.619368114668 1263.7585630600595 1236.888668931041 849.9522865390219 1113.3707496215864 1302.9169927304722 0.7889243146864715 0.8839244925245472 0.7961411652189081 0.7413588736973274 0.9414409167725181 0.9699455683755034 0.9493226934886633 0.652345691460981 0.8545216278807899 1.0 10.347529459135501 -6.265529699429367 24.921667471645694 0.8837171694389517 0.8079365868877817 0.17223172550832166 0.09679134656625268 816.1152561708722 4972455.599764232 0.03191407353702127 0.03748660923670625 5.425881449185715e-07 6.265529699429367 -0.07578058255117004 S(ph)RSPVDLR ddPTM_A459_Selumetinib_30min_R1 1 SRSPVDLR 8 1 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 S(0.598)RS(0.402)PVDLR 80.219 0.025669 20255000.0 3569.1 4006.4 3848.3 4611.5 4807.3 3431.7 4108.7 3513.6 2072.7 3095.8 True False 3652.253085740332 3537.328825475172 3325.7219971987865 3806.1880935760473 4372.48056379775 3397.1802137342984 3798.7774510666527 3420.4079142187225 3517.220515981562 3493.1760856456185 1.0455393590802373 1.0126397120405664 0.9520625114963586 1.0896067075509528 1.2517206280454698 0.9725190286553854 1.0874852449256225 0.979168478873447 1.0068832574558004 1.0 11.770323653270836 -7.769054459046281 24.99400297073078 0.9947693884699758 1.0582026225982735 0.12245304261126033 0.07781654382373387 423.5932260156601 1390277.8488635807 0.04397773564962593 0.021754036249147502 1.7019450769075866e-08 7.769054459046281 0.06343323412829771 S(ph)RSPVDLR ddPTM_A459_Selumetinib_30min_R2 2 SRSPVDLR 8 1 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 S(0.909)RS(0.091)PVDLR;S(0.991)RS(0.009)PVDLR 84.743 0.019934 59486000.0 48720.0 44856.0 50910.0 54813.0 50232.0 36473.0 38899.0 43813.0 33630.0 46332.0 True False 46012.33744161269 48296.31096522724 47634.50602661694 47347.37484230093 43921.40708022228 41496.824681070975 40707.88057690624 43940.4885763674 40356.93970071027 44994.274775007005 1.0226264935193752 1.0733879189459548 1.0586792711919986 1.052297766306059 0.9761554619971189 0.9222689973018798 0.9047346752551342 0.9765795492002252 0.8969349967860213 1.0 15.457453819232146 -6.392865672071191 2.9530394068682044 0.9368452346583738 1.0546639639960032 0.7362312033224991 0.031483906305674804 0.12588911514064002 2.1049764529379615 0.009922668821238803 0.011410202345051853 4.0470104697648483e-07 6.392865672071191 0.11781872933762938 S(ph)RSQPCDLDAR ddPTM_A459_Selumetinib_30min_R1 1 SRSQPCDLDAR 11 1 Q9NYF3 Q9NYF3 FAM53C Protein FAM53C 1 S(0.833)RS(0.167)QPCDLDAR 142.1 0.0045052 4142900.0 966.98 1044.8 1443.2 1254.9 1134.5 1019.2 1183.5 1215.7 759.62 890.0 True False 989.5087525844574 922.4743302856573 1247.2213669301473 1035.7552723904541 1031.8846753122425 1008.9477733595587 1094.2276421586832 1183.4556868498692 1289.0196595503044 1004.2401693341307 0.9853307832135005 0.918579398090908 1.2419552662956383 1.0313820379015708 1.0275277835146166 1.0046877272680195 1.089607521758684 1.178458821891748 1.283577075397212 1.0 9.971888623344629 -7.603759894149139 3.737357742796075 1.172587045716626 1.0388445310473942 0.21059052209659257 0.10111443090666108 0.32990140314130906 9.034999200704418 0.051622071937639145 0.02824595569488618 2.490233698716078e-08 7.603759894149139 -0.13374251466923193 S(ph)RSTTAHSWQR ddPTM_A459_Selumetinib_30min_R1 1 SRSTTAHSWQR 11 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 S(0.977)RS(0.023)TTAHSWQR 75.566 0.029165 1640600.0 592.24 730.07 938.77 836.11 868.65 643.37 583.1 614.95 706.14 787.52 True False 606.0380397015649 644.593064999665 811.2901902944942 690.0990842285303 790.0807608726134 636.8982819332213 539.1162975434971 598.639528360884 1198.2680055749604 888.6058630943984 0.6820099493730037 0.7253981678164874 0.9129921644556032 0.7766087451025738 0.8891239566226917 0.716738779682756 0.6066990101394657 0.6736839730904289 1.3484808679994789 1.0 9.795399850174304 -8.25344372616015 24.99608907702982 1.1742404434950353 0.752577494169012 0.6746181333528216 0.11839866838633278 312.4316644273774 976734.2527013181 0.08444645025690947 0.030675139310988888 5.578998875058525e-09 8.25344372616015 -0.42166294932602333 S(ph)RSTTELDDYSTNK ddPTM_A459_Selumetinib_30min_R1 1 SRSTTELDDYSTNK 14 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.621)RS(0.324)T(0.055)T(0.001)ELDDYSTNK 257.54 5.8375e-35 36294000.0 3688.3 4484.2 4564.0 4825.2 4340.5 3503.3 3997.0 3997.9 2232.9 3668.4 True False 3774.230213817512 3959.187779351977 3944.2338682574764 3982.569400221868 3947.9025413775144 3468.059982741895 3695.5030719968395 3891.862704990614 3789.068215436497 4139.2748732419395 0.9118095148055438 0.9564930816616883 0.9528803930743299 0.9621418055531699 0.9537667012399832 0.8378423972664711 0.8927899656739801 0.9402281375777423 0.9153942010303956 1.0 12.015162340211633 -3.551604267976006 15.288176736954084 0.9296161409923269 0.31584978289918486 0.0 0.042742476061751064 0.0 0.0 0.010148155398116787 0.0 0.00028079911327909594 3.551604267976006 -0.6137663580931421 S(ph)RSWPASPR ddPTM_A459_Selumetinib_30min_R2 3 SRSWPASPR 9 1 Q86YD1 Q86YD1 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 S(0.959)RS(0.04)WPAS(0.001)PR;S(0.93)RS(0.07)WPASPR;S(0.994)RS(0.006)WPASPR 86.13600000000002 0.018833000000000003 104866000.0 38266.2 38510.4 44746.5 45788.3 58412.4 37860.6 44779.2 45379.0 40214.6 45512.0 True False 36139.51779573562 41464.02384954714 41867.5589063055 39551.854550776785 51074.11209851842 43075.5539856923 46861.521528301455 45511.04537710211 48258.643689806224 44197.95030562288 0.817674067368186 0.938143591791678 0.9472737676022749 0.8948798366729912 1.1555764859082334 0.9746052404654659 1.0602645870285916 1.0297094110111296 1.0918751515874423 1.0 15.431691845263893 -5.1716119390939115 0.6711718700723864 1.0513769464299545 0.7723873398881564 0.5562538933981391 0.06245199027532113 1.5795085089949543 0.7594697859038168 0.02935806175584251 0.3115581789228459 6.735782587769157e-06 5.1716119390939115 -0.27898960654179805 S(ph)RT(ph)SVQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R2 1 SRTSVQTEDDQLIAGQSAR 19 1 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 2 S(0.664)RT(0.664)S(0.664)VQT(0.007)EDDQLIAGQSAR 71.872 0.046083 14516000.0 7469.3 8352.6 11629.0 11538.0 9275.4 9191.4 14003.0 11317.0 8169.7 10538.0 True False 7054.186207976964 8993.217562157948 10880.802800697862 9966.504495839825 8110.141328871908 10457.431918778155 14654.167246418105 11349.930596369793 9803.868280490415 10233.740558987833 0.6893067268332879 0.8787810781718138 1.0632283218418845 0.973886765879236 0.792490417567713 1.021858220706393 1.431946331055658 1.1090696047010553 0.9579946085187903 1.0 13.321045943942611 -6.999942650682391 24.99951964868205 1.1471361201615635 0.8961662029546432 0.36554151612632857 0.15092430436498844 2.252545207269595 981238.792570259 0.0552689521050481 0.04826559228621939 1.0001320604030262e-07 6.999942650682391 -0.2509699172069203 S(ph)RTAS(ph)GSSVTSLDGTR ddPTM_A459_Selumetinib_30min_R1 1 SRTASGSSVTSLDGTR 16 1 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 2 S(0.814)RT(0.186)AS(0.934)GS(0.017)S(0.013)VT(0.034)S(0.002)LDGTR 109.07 0.030072 0.0 1191.3 1427.7 1483.6 1959.3 1259.8 1545.0 1313.0 1238.3 749.71 970.8 True False 1219.0549721337193 1260.5442202802772 1282.135268831462 1617.1450356160797 1145.8513124357544 1529.4587027477603 1213.959352897635 1205.4562614347224 1272.203113348066 1095.4116363927799 1.112873856396213 1.1507493424401474 1.1704597853767267 1.4762898091363919 1.0460463211885112 1.396241058552481 1.1082220715631943 1.1004596093248766 1.1613927322677209 1.0 10.09725739575464 -8.352179009608326 0.8460906427447454 1.0122519418479425 1.2189909070644038 0.19489815148095513 0.12739150300334054 0.9576578934771118 1.510706548371788 0.11905581721840078 0.04388910290807482 4.444480349597433e-09 8.352179009608326 0.2067389652164613 S(ph)RTGS(ph)ESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 2 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.742)RT(0.262)GS(0.713)ES(0.126)S(0.158)QT(0.001)GTSTTSSR;S(0.845)RT(0.307)GS(0.834)ES(0.013)S(0.001)QTGTSTTSSR 123.12 0.001765 24497400.0 16879.5 21890.6 21100.9 23454.2 20782.8 12664.5 13426.0 14289.6 13304.1 20859.5 True False 15941.404963992229 23569.538630626972 19743.291066922833 20259.69749924825 18171.87886341065 14408.919918115414 14050.33560311429 14331.180370229378 15965.291747612837 20257.232035510206 0.7869488257846636 1.1635122996720584 0.9746292599262104 1.0001217078292692 0.8970563614790014 0.7112975698188722 0.693596024298115 0.707459950357844 0.7881279989105249 1.0 14.306149436143773 -6.555407378519647 3.5734540141257183 0.7570428339020887 0.9916877693061844 0.3811573764998708 0.11876651495152196 0.2049700265601694 5.548858892398524 0.038472748756794455 0.039906188196379117 2.78350894627907e-07 6.555407378519647 0.2346449354040957 S(ph)RTGSESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R1 3 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.764)RT(0.227)GS(0.009)ESSQTGTSTTSSR;S(0.324)RT(0.324)GS(0.324)ES(0.026)S(0.003)QTGTSTTSSR;S(0.598)RT(0.343)GS(0.058)ES(0.001)SQTGTSTTSSR 104.23 0.0010251 1832500.0 127.09 314.58 462.23 333.2 104.52 268.58000000000004 127.67 159.22 136.76 162.03 True False 130.05094972590825 277.7488273557256 399.4617048476453 275.01287493864 95.06618445450479 265.8783290511286 118.03974911229334 154.99696838055124 232.0717314448007 182.82812880585297 0.7113289983075343 1.519179948784959 2.1849028782208766 1.504215334559809 0.519975701088406 1.4542528591618826 0.6456323208210534 0.8477741876642192 1.2693436888545744 1.0 7.51434424138929 -6.148234227547342 9.169642972332573 0.9583747206613749 1.536628856426388 0.2698564426763458 0.418150865059383 0.45343441461854916 33.892616130361326 0.12502634729401083 0.16161747108602875 7.108300390993332e-07 6.148234227547342 0.578254135765013 S(ph)RTGSESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 2 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.499)RT(0.499)GS(0.002)ESSQTGTSTTSSR;S(0.774)RT(0.193)GS(0.033)ESSQTGTSTTSSR 150.59 7.7363e-05 17555810.0 3484.9 1231.5 2826.9 2797.2 2594.1 1823.4 2148.5 2151.5 1989.3 1231.1 True False 3291.2232091600185 1325.952090103383 2645.020331696002 2416.2165345608546 2268.205966451756 2074.5567988228217 2248.409507171983 2157.7605088000014 2387.21558568608 1195.5549442180593 2.7528832740619964 1.1090683004707982 2.2123787321426294 2.0209999935562615 1.8971992691939836 1.735224975527716 1.88064088400599 1.8048191923218242 1.996742681907785 1.0 10.223464718291247 -11.612583614479632 0.4076046520023662 1.0339554486958979e-11 1.9363851814200777 0.34395186180978177 0.38729186724088543 59.212660537684684 3.5430862420473095 55.54678673507327 0.22154504762667895 2.4401492222155414e-12 11.612583614479632 1.9363851814097381 S(ph)RTPLISR ddPTM_A459_Selumetinib_30min_R2 1 SRTPLISR 8 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.981)RT(0.019)PLISR 64.374 0.048249 2817400.0 4384.7 4669.2 4802.0 4901.0 5050.7 2600.1 2871.5 3570.7 3561.9 4562.8 True False 4141.01592734481 5027.312626155677 4493.044548022284 4233.475345303429 4416.185912169113 2958.2401736422175 3005.030439769306 3581.090145838793 4274.379527801365 4431.06010842187 0.9345429369089828 1.134562046811449 1.013988625313975 0.9554091440233676 0.9966431969125208 0.6676145439822978 0.6781741538684641 0.8081790944411731 0.9646403847416308 1.0 12.113436182132293 -6.659315564758582 8.372737584929313 0.8029721176992007 1.013259959740072 0.39911706821836224 0.11100620519264513 0.24017416033539304 17.70122243933599 0.03755778050033294 0.03751580630527335 2.1912121897567503e-07 6.659315564758582 0.21028784204087125 S(ph)RTPLLPR ddPTM_A459_Selumetinib_30min_R1 1 SRTPLLPR 8 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(1)RTPLLPR 94.309 0.012562 4453500.0 519.44 798.85 575.84 1046.3 1107.7 1090.4 1088.5 1093.2 1009.5 867.59 True False 531.5419413457063 705.3202706247102 497.64409086270496 863.5833464834908 1007.5087305803195 1079.4315660039858 1006.3935686436226 1064.2047847859471 1713.047769037191 978.953627542245 0.5429694792389628 0.7204838419113712 0.5083428641171566 0.8821493911326503 1.0291690047768296 1.1026380981027673 1.028029868146327 1.0870839586730305 1.7498763177761119 1.0 9.935096711606402 -6.3211909260445145 0.7140132347036937 1.2718002823745924 0.5347352179690711 0.6216334815029563 0.20516579505025367 0.5135611732294652 0.5696374134987862 0.12690303274827192 0.21268682176817813 4.773193867232525e-07 6.3211909260445145 -0.7370650644055213 S(ph)RTPLLPR ddPTM_A459_Selumetinib_30min_R2 3 SRTPLLPR 8 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.999)RT(0.001)PLLPR;S(1)RTPLLPR;S(0.998)RT(0.002)PLLPR 87.806 0.017573 15282100.0 15409.6 18356.5 19550.5 19487.2 17135.8 11109.099999999999 15996.599999999999 14446.5 12418.0 16618.1 True False 14553.196121516321 19764.384524549518 18292.642114974926 16833.009742704962 14983.04760800432 12639.27768663081 16740.473596661563 14488.536923253174 14901.946987910194 16138.292273990859 0.9017804284639742 1.2246887210242572 1.1334930489799162 1.0430477684329549 0.9284159286265761 0.7831855732964258 1.0373138193587685 0.8977738584276046 0.9233905753415304 1.0 13.978200302762808 -6.144658129271361 3.4291572381797595 0.9211976284772565 1.0989189742426293 0.3549590277058374 0.09771969916064115 0.24876036595015444 5.420429608578438 0.029337841339445617 0.03914209712345915 7.16707370538859e-07 6.144658129271361 0.1777213457653728 S(ph)RTPPSAPSQSR ddPTM_A459_Selumetinib_30min_R1 5 SRTPPSAPSQSR 12 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.868)RT(0.132)PPSAPSQSR;S(0.499)RT(0.499)PPSAPSQS(0.002)R;S(0.975)RT(0.025)PPSAPSQSR;S(0.5)RT(0.5)PPSAPSQSR;S(0.5)RT(0.5)PPSAPSQSR 119.39 0.0023589 615595520.0 10364.46 12002.529999999999 12708.78 13221.710000000001 11966.330000000002 10252.039999999999 11384.380000000001 10630.5 6264.43 9759.18 True False 10605.931752271516 10597.268207775185 10982.997480331569 10912.786550735198 10883.977564327159 10148.913785707538 10525.647050983074 10348.544607269503 10630.280174135372 11011.86581546322 0.9631366682091532 0.9623499219264148 0.9973784338080915 0.9910024998135293 0.988386323146394 0.9216343493267148 0.9558459236038473 0.9397630502124119 0.9653477759607266 1.0 13.426771314814845 -6.719337974912839 24.999949118668642 0.9527112671051678 0.980971817015522 0.2268439146215807 0.021514651323688412 184.84014161842094 109758.18046778206 0.0069644954078396165 0.006964437467483259 1.9083675583830066e-07 6.719337974912839 0.028260549910354205 S(ph)RTPPSAPSQSR ddPTM_A459_Selumetinib_30min_R2 3 SRTPPSAPSQSR 12 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.859)RT(0.14)PPSAPSQSR;S(0.5)RT(0.5)PPSAPSQSR;S(0.5)RT(0.5)PPSAPSQSR 88.78 0.02427 69908000.0 25092.7 20224.3 26704.120000000003 29518.0 29810.5 19922.86 22950.3 25500.199999999997 17964.2 27474.9 True False 23698.148188036856 21775.43877862595 24986.005992447477 25497.5974786098 26065.438480748646 22667.05312328358 24017.534425156715 25574.40136021464 21557.541961685973 26681.628248636804 0.8881822341276201 0.8161210618672975 0.9364498208134672 0.9556237438362669 0.9769058408974857 0.8495378509908467 0.9001525019892217 0.9585022743700534 0.8079545131503499 1.0 14.703559089346168 -5.272407028788767 24.67398435422446 0.9212893533520934 0.8521516465006013 0.19525958812511657 0.057548492944443884 868.3331835316085 1953497.2139031223 0.014700915687315661 0.031082969012128973 5.340635905334596e-06 5.272407028788767 -0.06913770685149212 S(ph)RTPSLPTPPTR ddPTM_A459_Selumetinib_30min_R1 1 SRTPSLPTPPTR 12 1 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 S(0.628)RT(0.37)PS(0.002)LPTPPTR 64.374 0.044829 5087100.0 936.09 1461.9 1032.7 1056.5 1088.8 1099.1 1214.5 1278.7 665.27 889.55 True False 957.8990756859351 1290.7400683811277 892.4650122150517 872.0021079612043 990.3182322432529 1088.0440519029542 1122.8892872004399 1244.784722197028 1128.914600601657 1003.7324074507587 0.9543371007804468 1.2859404147957123 0.8891463557321022 0.8687595433686175 0.9866357057838008 1.0839981292088863 1.1187137915097423 1.2401559548709649 1.1247166996120321 1.0 9.971158986321518 -6.980923822077788 3.004018139960543 1.1394768203601051 1.0004099821600243 0.18821958902185532 0.12000444593709096 0.4330474333459813 8.008859025864686 0.04967068460882937 0.04070856543541838 1.0449034856428555e-07 6.980923822077788 -0.1390668382000808 S(ph)RTPVQDHR ddPTM_A459_Selumetinib_30min_R2 3 SRTPVQDHR 9 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.657)RT(0.343)PVQDHR;S(0.598)RT(0.402)PVQDHR;S(0.5)RT(0.5)PVQDHR 83.137 0.021759 3284440.0 1632.29 914.08 1233.47 439.1 474.02 2709.59 4093.6400000000003 7417.9 2325.7300000000005 4465.0 True False 1541.5738563745897 984.186996769549 1154.109883100593 379.2938225102504 414.4693698074332 3082.8114272909575 4284.002371393771 7439.484860900545 2790.9409863256883 4336.083848536784 0.35552215091384715 0.22697600672589943 0.2661641064644192 0.08747382102360485 0.0955861058699998 0.710966746718068 0.9879888214890983 1.7157151754367035 0.6436547548008081 1.0 12.082176939577717 -7.036581547976889 2.539277368133759 1.1508443623432472 0.2051540753210782 0.7133340845063187 0.2620918343190841 0.14485850366893674 1.8599460359794535 0.10627791526003605 0.08275346912692785 9.192178559986833e-08 7.036581547976889 -0.945690287022169 S(ph)RTSVQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R2 1 SRTSVQTEDDQLIAGQSAR 19 1 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 S(0.333)RT(0.333)S(0.333)VQTEDDQLIAGQSAR 168.68 2.707e-09 33863000.0 24192.0 20173.0 21078.0 27032.0 30542.0 17067.0 28428.0 21527.0 19999.0 23973.0 True False 22847.505488249055 21720.20423358144 19721.864427991197 23350.194967199008 26705.040911055676 19417.82433119946 29749.958329013327 21589.640006013316 23999.358818748286 23280.83720066571 0.9813867642008912 0.9329649121450133 0.8471286602797624 1.0029791783661164 1.1470824988326473 0.8340689883198965 1.2778732170406069 0.9273566848101136 1.0308632207634711 1.0 14.506855319390626 -5.981142543635679 19.071534336358752 1.0382315026383826 0.9222914787311977 0.16649100790012517 0.11576865368685202 26.999827052971057 27301.37461315273 0.03099680156178839 0.04593748706535754 1.044377378617685e-06 5.981142543635679 -0.11594002390718494 S(ph)RVALVAMVIAAAGSGGPGR ddPTM_A459_Selumetinib_30min_R1 1 SRVALVAMVIAAAGSGGPGR 20 1 O95755-2;O95755 O95755-2 RAB36 Ras-related protein Rab-36 1 S(1)RVALVAMVIAAAGSGGPGR 98.592 0.010701 0.0 2316.6 2545.2 2584.6 3549.0 2429.2 2620.9 2855.2 2434.8 1562.4 1933.6 True False 2370.572272681084 2247.20680076862 2233.6255161915606 2929.2337729808937 2209.4792889100927 2594.5361255868006 2639.8299652652913 2370.2211946549824 2651.2786868189282 2181.7963948589604 1.0865231413283762 1.0299800687469225 1.0237552511566739 1.3425788858589853 1.0126881198063955 1.1891742656190984 1.2099341494401634 1.086362228959592 1.2151815325509863 1.0 11.091300760369089 S(ph)S(ph)PRT(ph)ISFRMK ddPTM_A459_Selumetinib_30min_R2 1 SSPRTISFRMK 11 2 E9PDI4;O00515 E9PDI4 LAD1 Ladinin-1 3 S(1)S(1)PRT(0.588)IS(0.412)FRMK 62.924 0.043869 0.0 5574.2 5255.2 5894.3 5561.2 6083.8 5729.7 6589.2 7066.8 9166.6 6167.1 True False 5264.408279290593 5658.256941868697 5515.067155228603 4803.7549663949085 5319.4986541379285 6518.914165962012 6895.6108562520985 7087.363218028284 11000.176136203707 5989.039798949878 0.8790070622361965 0.9447686326714375 0.9208599943175563 0.802091007516297 0.8882055943376187 1.0884740099915586 1.1513716869039974 1.1833888997149404 1.8367178221344405 1.0 12.54810900414767 -7.407600721128289 1.3578709932762234 1.3940105573771826 0.8913838995115753 0.48493737047734964 0.20194738031262208 0.3537186145911737 1.251726258172917 0.13012762200529399 0.06689948481664466 3.912003898145064e-08 7.407600721128289 -0.5026266578656073 S(ph)S(ph)S(ph)GIRY(ph)KK ddPTM_A459_Selumetinib_30min_R1 1 SSSGIRYKK 9 2 A0A3B3ISU0;Q02487-2;Q02487 A0A3B3ISU0 DSC2 Desmocollin-2 4 S(1)S(1)S(1)GIRY(1)KK 43.124 0.047177 0.0 535.92 533.88 699.49 774.39 712.13 539.83 844.14 498.4 443.91 389.62 True False 548.4058932812083 471.3730814059213 604.503100023537 639.157323600641 647.717967236763 534.3998003264235 780.4658401789873 485.18081296863886 753.2828480963846 439.6315222201843 1.2474216828486324 1.0722003714052142 1.3750221935195508 1.453847805027335 1.4733201203719897 1.2155629733456093 1.7752727016423997 1.1036078817060841 1.713441393583947 1.0 8.780151023105356 -5.355235853489739 5.913874893352539 1.4072638877575017 1.1613528233613126 0.1301200700417865 0.23373623826343798 0.36873109052352054 18.6706001919241 0.05595213606892675 0.11896277108615415 4.4133070758911245e-06 5.355235853489739 -0.24591106439618904 S(ph)SADDEIEETR ddPTM_A459_Selumetinib_30min_R2 2 SSADDEIEETR 11 0 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 S(0.99)S(0.01)ADDEIEETR;S(0.954)S(0.046)ADDEIEETR 190.85 1.9882e-05 6468900.0 9584.8 11489.0 9971.4 10537.0 14134.6 9930.2 13055.2 14192.8 13225.4 12678.9 True False 9052.115186994444 12370.169357042443 9329.850980039439 9101.842422661144 12358.885183072745 11297.994912619493 13662.29266838803 14234.098698255473 15870.849548551107 12312.827213261604 0.7351776346901717 1.0046571061859033 0.7577342570023777 0.7392162876173517 1.0037406494067858 0.917579262417564 1.1095983425864189 1.1560382072871576 1.2889687537771433 1.0 13.587874444234375 -7.071433635210567 1.2867972291051986 1.1704001468688827 0.8298207242872326 0.6248201640068768 0.10875791426364728 0.28594925034447055 0.9542728710665758 0.061086331703116205 0.04161745796890046 8.48333006802599e-08 7.071433635210567 -0.3405794225816501 S(ph)SATLWNSPSR ddPTM_A459_Selumetinib_30min_R2 1 SSATLWNSPSR 11 0 Q3KQU3-4;Q3KQU3;C9JIR3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 S(0.957)S(0.042)AT(0.001)LWNSPSR 99.844 0.016854 5383200.0 4461.1 5637.2 9165.5 10080.0 4498.4 8354.6 9691.3 1808.8 0.0 4251.4 True False 4213.169921198247 6069.5551135451005 8575.801708641864 8707.086611030114 3933.2707757937583 9505.370314492244 10141.96465294663 1814.0633085370396 0.0 4128.651035536237 1.0204713076824699 1.4701061100352297 2.0771437534507013 2.1089422516183234 0.9526769741349422 2.3022944377418586 2.4564838649845764 0.4393840246906277 0.0 1.0 12.011454767943155 -7.78195949042819 24.53001909806453 0.41476739873001744 1.7721352659946377 0.5543607216084493 0.5290310743235174 147.05255817110597 175785.54815289233 0.2949763879273067 0.1419809790659422 1.6521158950205475e-08 7.78195949042819 1.35736786726462 S(ph)SCSSEPNTPK ddPTM_A459_Selumetinib_30min_R2 3 SSCSSEPNTPK 11 0 I3L2J0;A0A0A0MQR4;Q96RK0;I3L135;I3L1Q4;I3L373 I3L2J0 CIC Protein capicua homolog 1 S(0.828)S(0.147)CS(0.008)S(0.017)EPNTPK;S(0.861)S(0.139)CSSEPNTPK;S(0.999)S(0.001)CSSEPNTPK 170.0 0.00038847 5181200.0 61962.0 48965.0 51369.9 65620.0 61643.0 48234.0 32958.6 27039.0 21432.3 21186.300000000003 True False 58518.40009353873 52720.45805270981 48064.81656131821 56682.442799186036 53898.85524458796 54877.79567534277 34491.24020622694 27117.679013452584 25719.35886849635 20574.59647038185 2.8442064551680937 2.562405446376726 2.336124386716886 2.7549722727628323 2.6196798232314316 2.6672598781872625 1.6763993527590584 1.3180175393714197 1.250054109470416 1.0 14.328576514891953 -7.434745387498406 2.3798144339108593 1.2007519674873346 2.62861543801904 0.9500510372373612 0.1510438904791 0.06409994571353601 0.7114537997199314 0.08201087068206575 0.04725665655442821 3.674976891038703e-08 7.434745387498406 1.4278634705317055 up S(ph)SDEDAAGEPK ddPTM_A459_Selumetinib_30min_R1 2 SSDEDAAGEPK 11 0 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 S(0.989)S(0.011)DEDAAGEPK;S(0.919)S(0.081)DEDAAGEPK 221.09 1.0447e-05 37528000.0 8563.5 7815.799999999999 8241.699999999999 9236.300000000001 7174.1 7237.4 7171.9 7105.400000000001 4628.26 6968.5 True False 8763.012888329647 6900.72250253316 7122.522408417539 7623.35359182401 6525.203921690231 7164.598327033428 6630.917808870179 6916.941710408045 7853.819185264066 7862.974853938083 1.114465332919231 0.8776223542260231 0.9058304955471533 0.9695253683796202 0.8298645287441249 0.9111816405523819 0.8433090442288721 0.8796850859752874 0.9988355973605294 1.0 12.940859525268976 -4.756710595836981 24.999958349305103 0.9058424474377536 1.1144656482698465 0.5244568575310835 0.05723727263938323 108.79548101093269 575107.5587733391 0.013655650498631468 0.1079222614914597 1.7510131360608287e-05 4.756710595836981 0.20862320083209296 S(ph)SDEDAAGEPK ddPTM_A459_Selumetinib_30min_R2 2 SSDEDAAGEPK 11 0 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 S(0.989)S(0.011)DEDAAGEPK;S(0.986)S(0.014)DEDAAGEPK 187.62 1.9346e-05 72469000.0 299820.0 236388.0 242680.0 253430.0 276220.0 204374.0 259299.0 265720.0 191636.0 272593.0 True False 283157.2046745551 254518.19949278038 227066.23301000617 218912.3968088648 241518.7741618691 232524.6633775451 271356.917291221 266493.2012076862 229968.55475721994 264722.5318083285 1.069637717425482 0.9614527246855716 0.8577518183243001 0.8269503744674352 0.9123468732036001 0.8783712583479816 1.0250616577197744 1.0066887747985114 0.8687154553346744 1.0 18.01412146921234 -7.252852384595642 24.74468265634457 0.9756738708294438 0.912637914505173 0.12537028181208676 0.07348053821674538 1198.7997337160202 3454522.4844852583 0.030170672932125102 0.022983525690278922 5.586600493608089e-08 7.252852384595642 -0.06303595632427084 S(ph)SDEENGPPSS(ph)PDLDR ddPTM_A459_Selumetinib_30min_R2 1 SSDEENGPPSSPDLDR 16 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 2 S(0.794)S(0.206)DEENGPPS(0.01)S(0.99)PDLDR 294.39 5.374799999999998e-171 0.0 31925.0 29671.0 35611.0 36552.0 40510.0 36519.0 34896.0 34636.0 37268.0 34359.0 True False 30150.736305900773 31946.67029269792 33319.82703032518 31573.554544282997 35420.771636005054 41549.160763524524 36518.73314511219 34736.78502570153 44722.641354923304 33366.96639459695 0.9036103537054847 0.957434065623388 0.9985872445305843 0.946251875909092 1.0615520517244466 1.245218407695957 1.0944576954716987 1.0410531366533335 1.3403268617840294 1.0 15.026132907351794 -6.454783623226166 3.985385110631631 1.1449088370634943 0.9566353463981775 0.48211871956883745 0.09375006254731691 0.20150790387508058 6.2150691651131025 0.029380125778376783 0.03268135908698745 3.5092667117317395e-07 6.454783623226166 -0.18827349066531684 S(ph)SDEENGPPSSPDLDR ddPTM_A459_Selumetinib_30min_R2 1 SSDEENGPPSSPDLDR 16 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 S(0.5)S(0.5)DEENGPPSSPDLDR 313.76 2.8163999999999983e-102 9149100.0 13536.0 10470.0 14001.0 15691.0 14509.0 13113.0 15408.0 12200.0 13499.0 9602.3 True False 12783.723308901262 11273.015333643863 13100.190903136194 13553.85873151522 12686.249707894278 14919.196722037768 16124.502530372778 12235.499980181268 16199.177193573836 9325.056649228392 1.3709003376359177 1.2088951046293812 1.4048376750848133 1.4534880849905338 1.3604474680530771 1.5999041381986958 1.7291586675462192 1.3121099892935988 1.7371666256755927 1.0 13.186896774353032 -5.718950799386417 1.3744392711656153 1.494888599260009 1.2876505563255112 0.06837340262601299 0.2088956624555055 0.964164571522369 3.607633736357629 0.06633034222746712 0.17002569773767828 1.910069635423249e-06 5.718950799386417 -0.20723804293449777 S(ph)SDELDAWTDFR ddPTM_A459_Selumetinib_30min_R1 2 SSDELDAWTDFR 12 0 O43524;O43524-2 O43524 FOXO3 Forkhead box protein O3 1 S(0.703)S(0.297)DELDAWTDFR;S(0.995)S(0.003)DELDAWT(0.002)DFR 160.18 0.00047038 3694500.0 598.62 758.3299999999999 800.38 700.13 801.9 650.87 894.83 965.26 525.48 585.4200000000001 True False 612.5666812882462 669.5443710619472 691.6927921726381 577.8654385677972 729.3682865869434 644.3228387426765 827.3322526682337 939.658169193637 891.7011804593 660.564359473693 0.9273383774085403 1.0135944536811055 1.0471239967044947 0.8748056571326579 1.1041593088190078 0.9754126596476428 1.2524627476532546 1.4225081261458203 1.3499081015660095 1.0 9.367555321375661 -7.309521131390203 4.730393548888632 1.2968714592303698 0.993366089857406 0.5363767287385253 0.11909488097267412 0.14492624193948334 7.365909184175246 0.048501376766634796 0.032725156207683945 4.9031916483812975e-08 7.309521131390203 -0.3035053693729638 S(ph)SDGGSEEPPDRR ddPTM_A459_Selumetinib_30min_R2 1 SSDGGSEEPPDRR 13 1 Q9HCD6;Q9HCD6-2;Q9HCD6-3;Q9HCD6-4 Q9HCD6 TANC2 Protein TANC2 1 S(0.5)S(0.5)DGGSEEPPDRR 218.94 2.7286e-08 1906700.0 8583.4 6768.7 8028.5 7718.6 8150.7 6130.4 6906.8 6701.3 6993.5 9647.1 True False 8106.368990072625 7287.837525199165 7511.955050769869 6667.313364672322 7126.736197817487 6974.806953769565 7227.979885564562 6720.7996735400675 8392.395414716542 9368.563156824013 0.8652734527565188 0.7779034418838007 0.8018257362441111 0.7116687215601343 0.7607074936167142 0.74449057310236 0.7715142401852454 0.7173778477059923 0.8958039001534152 1.0 13.193612085430509 -8.494107340360882 3.9140127346766653 0.9992900028096215 0.7679036792596212 0.7649259509753368 0.04164562933409911 0.08577937831184423 3.225648115593641 0.04045403983254086 0.010620167490788904 3.2054769598943232e-09 8.494107340360882 -0.23138632355000033 S(ph)SDGSLSHEEDLAK ddPTM_A459_Selumetinib_30min_R1 1 SSDGSLSHEEDLAK 14 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YEF9;E9PJZ7 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 S(0.71)S(0.287)DGS(0.003)LSHEEDLAK 90.689 0.01793 3869900.0 1837.5 1707.7 1987.2 1665.1 2065.4 1634.3 1769.3 1760.8 748.25 1599.3 True False 1880.3101748474019 1507.7616901118076 1717.3491549082514 1374.3215427981074 1878.5849346759858 1617.8604258256742 1635.8402765283984 1714.0978641155286 1269.7255999822478 1804.5857335012083 1.0419622298571956 0.8355167959720535 0.9516583906358924 0.7615717653556343 1.0410061987086676 0.8965273280126986 0.9064907508465033 0.9498567079935196 0.7036105718949471 1.0 10.817451970074497 S(ph)SDIVSSVR ddPTM_A459_Selumetinib_30min_R2 4 SSDIVSSVR 9 0 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 S(0.972)S(0.028)DIVSSVR;S(0.982)S(0.018)DIVSSVR;S(0.958)S(0.042)DIVSSVR;S(0.966)S(0.034)DIVSSVR 163.9 0.00096556 48952100.0 125038.0 68075.0 119835.0 119142.0 130313.0 78042.0 93316.0 130303.0 76738.0 89510.0 True False 118088.88852677276 73296.13360437493 112124.94656648283 102914.6540685861 113941.91592699889 88791.57710525974 97655.3789021462 130682.16015717723 92087.74423886741 86925.61372509011 1.35850508804274 0.8432052471459148 1.28989536871247 1.1839393437481238 1.3107979460156614 1.0214662088676292 1.123436173956619 1.503379206162076 1.0593856090576823 1.0 16.407493727467475 S(ph)SDSEEAFETPESTTPVK ddPTM_A459_Selumetinib_30min_R1 1 SSDSEEAFETPESTTPVK 18 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 S(0.38)S(0.38)DS(0.241)EEAFETPESTTPVK 246.03 2.2072e-26 6603600.0 2544.1 2934.9 2346.4 2557.7 2603.1 2341.2 2957.3 2659.7 1445.3 2575.3 True False 2603.372580043142 2591.2805436020058 2027.7717678526185 2111.045708975268 2367.6500646146314 2317.649653639518 2734.228480064111 2589.156116076824 2452.5685394645407 2905.864840546278 0.8959028457613086 0.8917415935680156 0.6978204008523033 0.7264775978288134 0.8147832726347771 0.7975765497764237 0.9409344997443512 0.8910105108639824 0.8440064056810979 1.0 11.504751885634086 -7.251818294759579 23.940045043524243 0.9099053966797808 0.800169520074506 0.39731660011425374 0.0688883011906503 447.7222814615475 1114064.5012085233 0.028464972109026477 0.021736862786229872 5.599918484732878e-08 7.251818294759579 -0.10973587660527473 S(ph)SDSEEAFETPESTTPVK ddPTM_A459_Selumetinib_30min_R2 2 SSDSEEAFETPESTTPVK 18 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 S(0.5)S(0.5)DSEEAFETPESTTPVK;S(0.5)S(0.5)DSEEAFETPESTTPVK 255.72 6.7493e-34 6835500.0 50756.0 40190.0 49487.0 55316.0 51789.0 40520.0 44477.0 52711.0 37015.0 45142.0 True False 47935.18471236648 43272.44376878192 46303.060297371696 47781.865374577545 45282.8028204657 46101.26219606273 46545.26862950351 52864.38028322416 44419.034285512644 43838.63316699832 1.093446151246614 0.9870846931732665 1.0562158751844617 1.0899487945383226 1.0329428531214917 1.051612672786699 1.0617408725357511 1.2058856872166448 1.0132394893860708 1.0 15.41991519714684 -7.54045008812644 24.997310147020887 1.0925001745392777 1.050554090609087 0.0 0.059546772412323694 602.8143126656084 857564.8940679185 0.026428716497100838 0.015262825437855527 2.881044138596032e-08 7.54045008812644 -0.041946083930190614 S(ph)SDSWEVWGSASTNR ddPTM_A459_Selumetinib_30min_R1 1 SSDSWEVWGSASTNR 15 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 S(0.985)S(0.014)DSWEVWGSASTNR 90.853 0.015138 6932000.0 477.6 566.07 687.54 652.63 738.74 497.64 808.69 400.34 292.02 487.84 True False 488.72715075217366 499.7942612411965 594.1758443868858 538.6604218823671 671.9210974351404 492.63419342096796 747.6898622199457 389.7216827124095 495.5366117030616 550.4590159640022 0.8878538393930756 0.9079590791440157 1.0794188616319123 0.9785658991142645 1.2206559942676665 0.894951629701682 1.3583025085174398 0.7079940039312494 0.9002243533703292 1.0 9.104491342725892 -14.362037733573288 12.800925691963732 7.412033784304734 0.998765160904919 0.0 0.17635182793683513 0.0 0.0 0.0 0.03939970456753443 4.344724734935705e-15 14.362037733573288 -6.413268623399815 S(ph)SEDLAGPLPSSVSSSSTTSSKPK ddPTM_A459_Selumetinib_30min_R1 2 SSEDLAGPLPSSVSSSSTTSSKPK 24 1 Q9NRF2-2;Q9NRF2-3;Q9NRF2 Q9NRF2-2 SH2B1 SH2B adapter protein 1 1 S(0.962)S(0.038)EDLAGPLPSSVSSSSTTSSKPK;S(0.753)S(0.247)EDLAGPLPSSVSSSSTTSSKPK 186.54 2.1135e-26 119425000.0 7558.5 7166.1 6587.7 6476.200000000001 6279.3 6509.3 7311.1 6902.4 3868.7 6406.3 True False 7734.598343719234 6327.089680570491 5693.126523645877 5345.253243330195 5711.3384237004575 6443.822351971524 6759.617840799617 6719.325929844972 6564.901341331531 7228.611007646339 1.0699978648093897 0.8752842937429847 0.7875823609298874 0.739457862330128 0.7901017799490209 0.8914329938566794 0.9351198776154054 0.9295459283584839 0.9081829599610846 1.0 12.819502741673316 -7.025705482612397 4.438827224848533 0.9356239859704998 0.8433351275764454 0.191076977335636 0.08613091515334266 0.37817537104018384 17.84075500293925 0.035515999945818 0.028598742716111663 9.425285568522274e-08 7.025705482612397 -0.09228885839405443 S(ph)SEDLAGPLPSSVSSSSTTSSKPK ddPTM_A459_Selumetinib_30min_R2 2 SSEDLAGPLPSSVSSSSTTSSKPK 24 1 Q9NRF2-2;Q9NRF2-3;Q9NRF2 Q9NRF2-2 SH2B1 SH2B adapter protein 1 1 S(0.799)S(0.201)EDLAGPLPSSVSSSSTTSSKPK;S(0.823)S(0.177)EDLAGPLPSSVSSSSTTSSKPK 191.71 9.1462e-27 134487000.0 175149.0 182572.0 187692.0 205353.0 198499.0 180298.0 185772.0 203535.0 148135.0 188776.0 True False 165414.91975699962 196574.68533849315 175616.1010635981 177383.56714631635 173561.78101642473 205132.41291771256 194410.76610023458 204127.25315296664 177766.13923772605 183325.5463810484 0.9023015232867714 1.0722711003402983 0.9579466939025183 0.96758782749033 0.9467408358662173 1.1189515971295012 1.0604674031416506 1.1134686746204001 0.9696746729898357 1.0 17.48404831361095 -6.748172534364669 24.99869863460699 1.0601014523623762 0.9743527474903445 0.3319033226089534 0.05827302992815492 261.63504804384263 492997.96550021466 0.01851552868158437 0.018412757596645065 1.7857779888602397e-07 6.748172534364669 -0.08574870487203168 S(ph)SELLVR ddPTM_A459_Selumetinib_30min_R1 1 SSELLVR 7 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 S(0.986)S(0.014)ELLVR 96.668 0.022997 1534400.0 622.57 618.91 383.7 951.29 711.88 493.91 814.04 560.89 375.86 647.28 True False 637.0746696896588 546.4477294765468 331.59564751323296 785.1650594249066 647.4905796926223 488.94171383439925 752.6363074126357 546.013375172512 637.8069682717376 730.3646930411189 0.872269259124485 0.748184755757056 0.4540137970423009 1.0750315108409854 0.8865305043656719 0.6694487267703564 1.0304938266919523 0.7475900469654438 0.8732719069647437 1.0 9.512473214672903 -14.52287874520761 0.05588953169970047 1.736242910851591 0.48408884697481924 0.12241815805885603 0.16660641010613922 996.1671071922841 4.073279052157952 102.81327159027383 19.244827028879147 3.0000000005023855e-15 14.52287874520761 -1.2521540638767719 S(ph)SELLVR ddPTM_A459_Selumetinib_30min_R2 3 SSELLVR 7 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 S(0.995)S(0.005)ELLVR;S(0.996)S(0.004)ELLVR;S(0.989)S(0.011)ELLVR 144.09 0.0030849 8290500.0 29246.4 26327.0 30024.699999999997 31791.8 31328.7 19156.1 25173.8 25342.5 20125.2 24987.7 True False 27621.00217061539 28346.19624535264 28092.943490421632 27461.701996086005 27392.90862386846 21794.67889323783 26344.43158093836 25416.242479323268 24150.802345070908 24266.2401751585 1.1382481163641982 1.1681330128089153 1.1576965894856903 1.131683433356879 1.1288484918199546 0.8981481571071392 1.0856412608949333 1.0473910377488984 0.9952428629546919 1.0 14.566662973376268 -6.578832489051372 13.8058110258653 1.0132494396690426 1.1483547334435862 0.6987988487153336 0.04583981731781789 0.8196539062303083 201.37868413324577 0.014926282507960438 0.014925923484037347 2.637348436623487e-07 6.578832489051372 0.1351052937745436 S(ph)SEMLVK ddPTM_A459_Selumetinib_30min_R1 1 SSEMLVK 7 0 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 S(0.991)S(0.009)EMLVK 96.331 0.023214 6501300.0 2932.3 3539.6 3857.0 3810.6 2964.6 3083.9 3324.9 2453.0 1845.7 2267.6 True False 3000.616884737437 3125.181986484603 3333.240584984464 3145.1502438210728 2696.452453442642 3052.878765957164 3074.1001161076547 2387.938471533048 3132.018095405591 2558.6685482944663 1.172725903375629 1.221409466485121 1.302724648413842 1.229213625937419 1.0538498451626406 1.1931513239540634 1.201445227501921 0.9332738596113896 1.2240812111022754 1.0 11.321177556422933 -7.380814268757859 0.37881741427945875 1.0128796068406667 1.2521729171555698 0.3121900193262601 0.09228674973783682 1.5132229567948552 0.549771280538764 0.10857117722501046 0.1254754174245105 4.1608851769250436e-08 7.380814268757859 0.23929331031490308 S(ph)SEMLVK ddPTM_A459_Selumetinib_30min_R2 2 SSEMLVK 7 0 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 S(0.985)S(0.015)EMLVK;S(0.994)S(0.006)EMLVK 104.01 0.018263 13111200.0 49128.0 45834.0 54342.0 59230.0 53258.0 43716.0 53902.0 47876.0 37735.0 48050.0 True False 46397.66243496611 49349.320420461605 50845.69488309598 51162.77182255096 46567.25390743909 49737.48218566333 56408.54980478675 48015.31123370155 45283.05440399352 46662.67165110696 0.9943207448959994 1.0575759739914272 1.0896438863009206 1.096438973856681 0.9979551590105834 1.0658944382256224 1.2088581259673457 1.028987615469345 0.9704342422262332 1.0 15.509981290117608 -11.215605176249554 6.524097622343324 0.9993960526662727 1.0610494603721883 0.06132174115070754 0.06451797531970893 0.0005897784251652734 2.777750915948223e-05 0.06500595343611709 0.015613059570194932 6.086881174870867e-12 11.215605176249554 0.06165340770591554 S(ph)SEMSPVPMR ddPTM_A459_Selumetinib_30min_R1 1 SSEMSPVPMR 10 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RE77 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 S(0.506)S(0.038)EMS(0.456)PVPMR 136.96 0.0017987 26643000.0 4212.1 5041.9 4635.7 4612.3 4696.8 3819.0 4288.5 4019.0 2216.2 3610.7 True False 4310.233734680134 4451.59200408428 4006.197402077385 3806.8483885939045 4271.975269287391 3780.5843273745604 3965.0149923088443 3912.403064448156 3760.729535156239 4074.168516196343 1.0579419377341275 1.0926381631951496 0.9833165678226742 0.9343865805894526 1.0485514411847945 0.9279400968186083 0.9732083924723358 0.9602948549857206 0.9230667607895778 1.0 11.992289939107463 -5.3311238829891305 5.085716416602857 0.966848652633231 1.0751874369043741 0.5827381776687326 0.03614604616520547 0.1297186190835787 6.38183596986212 0.009204785817371684 0.020157756350169666 4.665262841853194e-06 5.3311238829891305 0.10833878427114307 S(ph)SEPVVIMK ddPTM_A459_Selumetinib_30min_R1 1 SSEPVVIMK 9 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.954)S(0.046)EPVVIMK 109.83 0.011204 2767200.0 2198.4 2450.3 2521.1 2658.7 2427.5 2147.4 2135.2 2136.4 1300.2 2042.8 True False 2249.6184426582477 2163.4177368864343 2178.748467411028 2194.407954980077 2207.933053609935 2125.7991056831984 1974.1401449406171 2079.735731994785 2206.34443714924 2305.0132785570363 0.9759676716771599 0.9385706177973767 0.9452216556318271 0.952015320429651 0.957883008375607 0.9222502644383775 0.856454998895473 0.9022662695013725 0.9571938078076652 1.0 11.170559346315923 -6.815346311638124 6.2043073077209625 0.9167180398355281 0.9524741875316463 0.07899317326824118 0.03641178593451949 0.35614387926120167 29.12281047468397 0.012736500527938366 0.011334870277957727 1.5298670407971494e-07 6.815346311638124 0.035756147696118123 S(ph)SEPVVIMK ddPTM_A459_Selumetinib_30min_R2 1 SSEPVVIMK 9 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.977)S(0.023)EPVVIMK 84.81700000000002 0.044221 0.0 15082.0 18068.0 17616.0 11786.0 11552.0 10390.0 13337.0 9850.4 11057.0 15879.0 True False 14243.802818029606 19453.757502223238 16482.605738850598 10180.72646801596 10100.734483809678 11821.128188970668 13957.196926764133 9879.063033178494 13268.708958392912 15420.532011403282 0.9236907525302305 1.261549049529383 1.0688740003692432 0.660205916403367 0.655018547760889 0.7665836807854034 0.9051047600979634 0.6406434632652788 0.860457275311959 1.0 13.912564918925165 -5.6943742499240235 6.908852990401704 0.7683299575052899 1.1071295478793284 0.5097612749852027 0.134191853704352 0.15311164829106777 12.719501455314942 0.035077982604623296 0.06083956027610389 2.021276608417246e-06 5.6943742499240235 0.3387995903740385 S(ph)SEYPISQNPEGLSADKFEVSADSSTSK ddPTM_A459_Selumetinib_30min_R1 2 SSEYPISQNPEGLSADKFEVSADSSTSK 28 1 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;H0Y881 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 S(0.824)S(0.176)EYPISQNPEGLSADKFEVSADSSTSK;S(0.802)S(0.194)EYPIS(0.004)QNPEGLSADKFEVSADSSTSK 123.52 2.1123e-12 9673900.0 1364.7800000000002 1443.32 1423.95 1101.21 1507.99 1229.37 1533.76 1469.59 703.02 1397.94 True False 1396.5767186004023 1274.3354234187357 1230.5854111974666 908.904345771848 1371.592570757259 1217.0036539786506 1418.0672483627402 1430.6116992989212 1192.9735934507444 1577.3792160887124 0.8853779131586188 0.807881459588768 0.7801455722542359 0.5762116912035761 0.8695388887893906 0.7715352412188787 0.8990021130613068 0.9069548303332425 0.7563010728700074 1.0 10.623313823295451 -7.2579354250101 24.060862210243698 0.8828107435325822 0.7775386270424969 0.23333207946734968 0.09600652966297704 293.2973114925282 2014020.01420929 0.03807850102117334 0.028264347185962553 5.521595334521106e-08 7.2579354250101 -0.10527211649008528 S(ph)SFSQHAR ddPTM_A459_Selumetinib_30min_R2 1 SSFSQHAR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.5)S(0.5)FSQHAR 107.55 0.0067774 0.0 4692.9 4279.2 5899.0 9172.2 8522.9 5653.5 4408.4 9167.6 8479.0 10708.0 True False 4432.087405167164 4607.400880203325 5519.464762345572 7922.930537072457 7452.177106307262 6432.218307636736 4613.399335078881 9194.276198222115 10175.036923054482 10398.832217274778 0.4262101082662416 0.4430690662120123 0.530777364902235 0.7619057959133818 0.7166359597501281 0.6185519848037733 0.44364590549071437 0.8841642990400761 0.9784788051634757 1.0 13.34413390320991 -5.955670321916026 0.1486494121433839 1.1736709940865253 2.4931426844376477e-14 0.6316226945488671 0.12784347813333666 11.934270944637703 0.4947759788703463 0.9229582026351087 3.1287431849360265 1.1074641541234398e-06 5.955670321916026 -1.1736709940865004 S(ph)SFSSDPDEK ddPTM_A459_Selumetinib_30min_R1 2 SSFSSDPDEK 10 0 P46013 P46013 MKI67 Antigen KI-67 1 S(0.888)S(0.112)FSSDPDEK;S(0.852)S(0.148)FSSDPDEK 245.13 6.7116e-10 13400400.0 8198.0 14464.0 7315.0 8874.6 7708.799999999999 8498.0 10882.0 9045.6 4974.9 9155.1 True False 8388.997449468849 12770.548155868828 6321.66317841881 7324.817706874116 7011.540401099181 8412.517835566654 10061.161978851542 8805.681303750247 8442.041947680162 10330.246263225734 0.8120810710324046 1.2362288207329806 0.6119566772500931 0.7090651587803349 0.6787389402379793 0.8143579176339744 0.973951803517783 0.8524173654114394 0.8172159436055922 1.0 13.334587026637193 -10.71220550463169 13.422894891355154 1.0000000000018623 0.8351399346521273 0.08355236775275632 0.16489126675371568 0.0 0.0 0.16548549743499788 0.0401361285548457 1.939967683371989e-11 10.71220550463169 -0.16486006534973496 S(ph)SFSSDPDEK ddPTM_A459_Selumetinib_30min_R2 1 SSFSSDPDEK 10 0 P46013 P46013 MKI67 Antigen KI-67 1 S(0.619)S(0.381)FSSDPDEK 127.83 0.0037244 0.0 111020.0 119890.0 107310.0 114700.0 124100.0 85512.0 87660.0 104620.0 90037.0 116260.0 True False 104849.95284827275 129085.17749289039 100405.79143029368 99077.66213146377 108509.44853192366 97290.50179935129 91736.36369499462 104924.4268792267 108046.91584397409 112903.27172024336 0.9286706332839896 1.1433253928437368 0.889308076732121 0.8775446505834014 0.9610832961580874 0.8617155226504147 0.8125217480172141 0.9293302601470488 0.956986579730811 1.0 16.78472776768838 -5.2917785989419865 24.95065415674367 0.9038451977356157 1.0359980487824232 0.3291539769792824 0.07074723346402242 595.5607552922218 489781.7051775183 0.017827691529984462 0.03711691900376331 5.107653191064191e-06 5.2917785989419865 0.13215285104680752 S(ph)SFSSDPDESEGIPLK ddPTM_A459_Selumetinib_30min_R1 1 SSFSSDPDESEGIPLK 16 0 P46013-2 P46013-2 MKI67 Antigen KI-67 1 S(0.856)S(0.143)FS(0.001)SDPDESEGIPLK 128.95 0.00091104 4258400.0 999.52 1917.4 1132.1 1473.2 1192.8 1332.0 1713.6 1453.8 631.05 1119.2 True False 1022.8068712726398 1692.909916624924 978.3670381801687 1215.9332753889698 1084.9114506059439 1318.601289359234 1584.3417723727248 1415.2405013920695 1070.8457599315693 1262.8602219311895 0.8099129686011841 1.3405362582694185 0.7747231413180721 0.9628407437915353 0.859090683010727 1.0441387466799803 1.2545662179064598 1.1206628230223747 0.8479527198140836 1.0 10.30247924976826 -6.9837670540430885 24.158810080026146 1.0777795143698452 0.961132010224708 0.07474212558031701 0.17433901620110978 418.4092713061212 622696.923472162 0.060901399507606355 0.05369213176197862 1.0380850723940747e-07 6.9837670540430885 -0.11664750414513725 S(ph)SFSSDPDESEGIPLKR ddPTM_A459_Selumetinib_30min_R1 1 SSFSSDPDESEGIPLKR 17 1 P46013-2 P46013-2 MKI67 Antigen KI-67 1 S(0.647)S(0.151)FS(0.188)S(0.014)DPDESEGIPLKR 73.984 0.012253 9018900.0 2563.5 3101.3 2761.6 2682.8 2364.4 2646.2 2944.4 2646.7 959.31 2515.0 True False 2623.224562297316 2738.1983542447447 2386.589888382964 2214.299342393109 2150.5404374687255 2619.581630557361 2722.30153744996 2576.500918306774 1627.879004769755 2837.824748174539 0.9243786333122697 0.9648933944938355 0.8409926969303385 0.7802805102103224 0.7578129829377531 0.9230949276351315 0.9592916332134709 0.9079140352004245 0.5736361999862415 1.0 11.470569782183759 -5.268822933729134 22.94205901278638 0.8413379554394051 0.9446360105874905 0.11036698077624274 0.11549580035587496 369.8578126030736 1149229.9998787853 0.030253673377976294 0.06531959128069721 5.38489285316883e-06 5.268822933729134 0.10329805514808532 S(ph)SFSSDPDESEGIPLKR ddPTM_A459_Selumetinib_30min_R2 3 SSFSSDPDESEGIPLKR 17 1 P46013-2 P46013-2 MKI67 Antigen KI-67 1 S(0.723)S(0.257)FS(0.014)S(0.007)DPDESEGIPLKR;S(0.497)S(0.497)FS(0.005)SDPDESEGIPLKR;S(0.488)S(0.488)FS(0.01)S(0.014)DPDESEGIPLKR 117.29 0.00081567 14506500.0 58717.0 71470.0 66914.0 61699.0 73789.0 57479.0 45456.0 52041.0 50923.0 77378.0 True False 55453.74420277449 76951.51918772927 62608.82609045456 53295.48976328836 64518.96613797024 65396.21050758856 47569.794069355215 52192.43069414864 61109.02290750129 75143.89608781182 0.7379673811159888 1.0240554881238138 0.8331857855399326 0.7092457609731627 0.8586055487803629 0.8702797420986491 0.6330493432728854 0.6945664706173539 0.8132267035514151 1.0 16.1973682988409 S(ph)SFTVDCSK ddPTM_A459_Selumetinib_30min_R2 1 SSFTVDCSK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 S(0.966)S(0.034)FTVDCSK 102.53 0.012617 0.0 16835.0 17741.0 21562.0 19495.0 20184.0 14581.0 15456.0 15119.0 13678.0 18435.0 True False 15899.378095844628 19101.67765369395 20174.72439493054 16839.747369249217 17648.305472750566 16589.40039686057 16174.734625482988 15162.993786914813 16413.982195251716 17902.73365011772 0.8880977847614954 1.0669698844326128 1.126907476210924 0.9406243592937823 0.9857883057224905 0.9266406304799985 0.9034784822024446 0.8469652782224746 0.9168422273401685 1.0 14.127892275550312 -6.521633347574906 1.4953409824590167 0.9053388829999105 1.0231579381700993 0.2562090170506389 0.07009490458662905 0.4678990156200477 2.140694654841388 0.028820545572142704 0.03188188376067798 3.008615249362112e-07 6.521633347574906 0.11781905517018876 S(ph)SFYVNGLTLGGQK ddPTM_A459_Selumetinib_30min_R1 4 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 1 S(0.772)S(0.228)FYVNGLTLGGQK;S(0.868)S(0.013)FY(0.007)VNGLT(0.111)LGGQK;S(0.83)S(0.17)FYVNGLTLGGQK;S(0.872)S(0.128)FYVNGLTLGGQK 156.2 0.00032265 52712800.0 7339.799999999999 10692.6 11571.400000000001 12583.3 10169.7 10181.0 10581.099999999999 11122.0 5063.4800000000005 8488.7 True False 7510.803059235357 9440.70542114512 10000.067437150443 10385.862872795286 9249.852430606365 10078.58838360838 9782.959108107518 10827.008430652499 8592.355738052935 9578.307331940041 0.784147219226268 0.9856340054639852 1.0440328432356718 1.0843108821704177 0.9657084608009597 1.0522306326505195 1.0213661734871504 1.1303676166819696 0.8970641095844429 1.0 13.225555011648867 -4.762580790425668 3.133594057979192 1.0295970695835341 0.7407412928869519 0.5836941908657938 0.06041474580586167 0.24745835470732536 3.512206178730795 0.01437395262203598 0.1829988037456717 1.7275045884129676e-05 4.762580790425668 -0.28885577669658224 S(ph)SFYVNGLTLGGQK ddPTM_A459_Selumetinib_30min_R2 2 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 1 S(0.967)S(0.033)FYVNGLTLGGQK;S(0.942)S(0.058)FYVNGLTLGGQK 192.78 0.00011263 8182600.0 30887.0 32470.0 29292.0 28389.0 35224.0 20699.0 26877.0 27120.0 25187.0 30947.0 True False 29170.42419045755 34960.34459249439 27407.38461071817 24522.36922624344 30798.84621344463 23550.09936318614 28126.83375576516 27198.9147100423 30225.103783579838 30053.479700037595 0.9706171957991626 1.163271106754758 0.9119537865255545 0.8159577350443306 1.0248013381760284 0.7836064109127663 0.9358927497413877 0.9050171554679666 1.0057106227050983 1.0 14.875244420580803 -5.287119940989256 24.218353924704576 0.9147890790238458 1.0669441420685761 0.30723224342179845 0.0858565758858983 468.0630391159209 441411.64357499534 0.02111373755017073 0.04398391554343439 5.1627376801758195e-06 5.287119940989256 0.15215506304473037 S(ph)SGDPEQIKEDSLSEESADAR ddPTM_A459_Selumetinib_30min_R1 2 SSGDPEQIKEDSLSEESADAR 21 1 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 S(0.918)S(0.079)GDPEQIKEDS(0.002)LS(0.001)EESADAR;S(0.933)S(0.063)GDPEQIKEDS(0.003)LS(0.001)EESADAR 68.303 0.0043122 11376500.0 2492.3 2709.3 3377.8999999999996 3426.1000000000004 2783.5 2696.5 2801.4 2573.0 1473.65 2061.2200000000003 True False 2550.365740828399 2392.0938964806014 2919.199733476542 2827.79595086217 2531.7329164668395 2669.3756582261085 2590.0881425799207 2504.7556817181153 2500.676418862464 2325.7976649830293 1.0965552933629796 1.0285047287198372 1.2551391625452692 1.2158391907590136 1.0885439239123635 1.1477247992875537 1.113634337834293 1.076944791642652 1.0751908717221583 1.0 11.18350987828207 -8.300645419181903 0.8168112619099201 1.0032875578863094 1.1422919788770745 0.33660823648761284 0.060618005136339165 0.7479341527576561 1.0919791865090702 0.06207828805526842 0.023555378731418317 5.004429561317031e-09 8.300645419181903 0.13900442099076504 S(ph)SGDPEQIKEDSLSEESADAR ddPTM_A459_Selumetinib_30min_R2 1 SSGDPEQIKEDSLSEESADAR 21 1 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 S(0.665)S(0.075)GDPEQIKEDS(0.037)LS(0.18)EES(0.042)ADAR 56.562 0.016332 3381900.0 14407.0 14777.0 16904.0 17539.0 14909.0 11754.0 13699.0 14439.0 10924.0 14888.0 True False 13606.316615790525 15910.3483844561 15816.41504368361 15150.157943537408 13035.99813184891 13373.006807811487 14336.030644053524 14481.015099494876 13109.105242062407 14458.144756330494 0.9410831642028625 1.1004419068006466 1.0939449915770416 1.0478632078229757 0.9016369908830179 0.9249462523160947 0.9915539570024362 1.0015818311097189 0.906693456387106 1.0 13.819594819628284 -6.189715167999048 8.70434683859549 0.9549259911933574 1.053506098648781 0.41360753308443754 0.053025971860464226 0.373563258833668 42.6704211918777 0.01580878138524436 0.02042947673758986 6.4607782019966e-07 6.189715167999048 0.09858010745542356 S(ph)SGENVENNSQR ddPTM_A459_Selumetinib_30min_R2 1 SSGENVENNSQR 12 0 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 S(0.996)S(0.004)GENVENNSQR 119.77 0.0033838 0.0 746.69 848.34 1755.7 1136.5 2114.8 1884.7 552.85 903.77 1018.9 1171.4 True False 705.1919590369 913.4049501569663 1642.740173461625 981.7067394281474 1849.1199174481242 2144.300317396827 578.5586204514923 906.3998210728217 1222.7084704446527 1137.5786383372877 0.6199061192531055 0.8029378535905183 1.444067353323981 0.8629792318032921 1.6254875532392576 1.8849688673224279 0.5085878030349862 0.7967799240654145 1.0748342393557888 1.0 10.151750563791287 S(ph)SGFISELPSEEGK ddPTM_A459_Selumetinib_30min_R1 4 SSGFISELPSEEGK 14 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(0.89)S(0.11)GFISELPSEEGK;S(0.886)S(0.114)GFISELPSEEGK;S(0.953)S(0.047)GFISELPSEEGK;S(0.886)S(0.114)GFISELPSEEGK 359.59 1.5287999999999988e-188 128641000.0 12294.5 16177.199999999997 16570.4 14325.8 12968.9 13579.8 13845.6 13125.0 7909.199999999999 11523.7 True False 12580.937929067422 14283.16590342375 14320.23069469188 11824.067958571337 11795.865284845266 13443.199541471877 12801.215244843495 12776.882363991555 13421.334734887525 13002.87914534351 0.9675501701154248 1.0984617901750418 1.101312296655478 0.9093422946106271 0.907173338534759 1.033863299905087 0.9844908271279109 0.9826194815143778 1.0321817641205924 1.0 13.666543485019194 -5.7497672919253695 24.99949584084979 0.9773816594641347 1.060043450612649 0.3075244898591928 0.05298628993714707 268.3151879566458 574676.886397016 0.014923593942492893 0.025574543613850313 1.7792325210806868e-06 5.7497672919253695 0.08266179114851435 S(ph)SGFISELPSEEGK ddPTM_A459_Selumetinib_30min_R2 3 SSGFISELPSEEGK 14 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(0.942)S(0.058)GFISELPSEEGK;S(0.887)S(0.113)GFISELPSEEGK;S(0.994)S(0.006)GFISELPSEEGK 310.9 5.613999999999997e-94 47886600.0 249316.0 181191.0 210689.0 225448.0 227009.0 183639.0 209177.0 198713.0 168851.0 207571.0 True False 235460.01481102454 195087.76707910845 197133.49912083813 194741.5934805075 198490.09993379097 208933.60534113433 218904.14497636195 199291.2219312919 202625.91809112756 201577.88589577324 1.1680845533461452 0.9678034185752868 0.9779520121704565 0.9660860992519761 0.9846819210933742 1.0364907063722475 1.0859531738989827 0.9886561764733276 1.005199142707034 1.0 17.620977851079964 -6.782625085268565 24.88834808200755 1.0264691816996367 1.0058702954569774 0.0 0.0606591677229788 1180.4666793492308 1386769.6438476427 0.021657339728723166 0.019118353656399807 1.649585820051335e-07 6.782625085268565 -0.020598886242659376 S(ph)SGFLNLIK ddPTM_A459_Selumetinib_30min_R2 1 SSGFLNLIK 9 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(0.947)S(0.053)GFLNLIK 84.821 0.035989 1551700.0 9146.2 6728.8 7383.7 10514.0 11176.0 7282.2 8286.3 8502.1 9808.1 9072.6 True False 8637.890819139533 7244.87732349788 6908.64078076471 9081.975062338352 9771.970965292336 8285.256948770186 8671.629368991957 8526.839703401576 11769.994061211315 8810.65046455428 0.9803919533399075 0.8222863172979579 0.7841238065859659 1.0307950699980242 1.1091089136500762 0.9403683623703176 0.984221244944217 0.9677877629699999 1.335882533141297 1.0 13.105032817694882 -5.823908040002313 7.9555998904556615 1.0467569183885688 0.8586271708753568 0.3631667526764495 0.11533478383878486 0.2682088661990781 29.920812535155317 0.03248948338778457 0.04851491140365738 1.5000024209698745e-06 5.823908040002313 -0.188129747513212 S(ph)SGGGYGGGPAGGHGGNR ddPTM_A459_Selumetinib_30min_R1 1 SSGGGYGGGPAGGHGGNR 18 0 Q9H2U1-3;Q9H2U1-2;Q9H2U1 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 1 S(0.892)S(0.108)GGGYGGGPAGGHGGNR 114.31 0.0011034 585420.0 83.525 187.55 239.49 144.94 120.1 60.08 218.36 0.0 0.0 152.28 True False 85.47096998864178 165.59155881037054 206.96857342440478 119.62894986076377 109.23697620537715 59.47564974827538 201.88892939735544 0.0 0.0 171.8266213328106 0.49742565689569873 0.9637130586979106 1.204519834115389 0.6962189498509357 0.6357395341772815 0.346137573368664 1.174957220431619 0.0 0.0 1.0 7.424809762278406 -6.234164275087906 2.434006577282475 0.487157260472352 0.8956625059663197 0.14291234403869413 0.3891518541599918 0.5482917421876331 6.400192575027798 0.13101427922032208 0.16979171510705074 5.832244535979042e-07 6.234164275087906 0.40850524549396766 S(ph)SGGGYGGGPAGGHGGNR ddPTM_A459_Selumetinib_30min_R2 1 SSGGGYGGGPAGGHGGNR 18 0 Q9H2U1-3;Q9H2U1-2;Q9H2U1 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 1 S(0.476)S(0.476)GGGY(0.048)GGGPAGGHGGNR 113.73 0.00075684 932010.0 6885.6 7890.7 8269.1 10246.0 10557.0 6737.6 7720.2 11255.0 7570.7 13358.0 True False 6502.925917240731 8495.891317400537 7737.075108715343 8850.477124664143 9230.735279222547 7665.643242156769 8079.204597286085 11287.750186634443 9085.051543032027 12972.319831747907 0.5012924443418165 0.6549245954149274 0.5964295676537325 0.6822586275589552 0.7115716694427804 0.5909230840420846 0.6228033768881786 0.8701412186129793 0.7003413160379884 1.0 13.663148878451832 -14.522878741641449 0.10272704024378078 2.1458595857936045 0.4326220871283004 0.7186460935111225 0.07292503595950713 97.42027658889133 0.6742436934289742 23.441658746630036 1.1379314557068674 3.0000000251365513e-15 14.522878741641449 -1.713237498665304 S(ph)SGGREDLESSGLQR ddPTM_A459_Selumetinib_30min_R2 2 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 S(0.5)S(0.5)GGREDLESSGLQR;S(0.499)S(0.499)GGREDLESS(0.001)GLQR 70.889 0.027735000000000003 33350000.0 27755.0 23510.0 27057.0 32846.0 27665.0 20183.4 21365.9 23800.0 17722.8 27218.0 True False 26212.488212068154 25313.14140343527 25316.18207743417 28372.318137489572 24189.47537176202 22963.48014333692 22359.45668572767 23869.254059697894 21267.855216406406 26432.145619143164 0.9916897625247674 0.9576650253130616 0.9577800622851906 1.0734020062654792 0.9151536814417018 0.8687709455832408 0.8459190944201708 0.903038837770736 0.8046208402016148 1.0 14.690005919491366 -6.490981087951629 9.318906138327266 0.8777095363746114 0.9904386966746735 0.46696238001775203 0.055726879876761455 0.3592469656092324 101.5392695068484 0.01664315189923416 0.018557544480439288 3.228634714718031e-07 6.490981087951629 0.11272916030006219 S(ph)SGNSPTPVSR ddPTM_A459_Selumetinib_30min_R2 2 SSGNSPTPVSR 11 0 O95429;O95429-2;H0YBT1 O95429 BAG4 BAG family molecular chaperone regulator 4 1 S(0.725)S(0.046)GNS(0.228)PT(0.001)PVSR;S(0.883)S(0.038)GNS(0.078)PT(0.001)PVSR 146.67 0.00068001 155492000.0 244810.0 253949.0 280260.0 274093.0 318491.0 202835.0 220433.0 229483.0 199042.0 275011.0 True False 231204.4402520771 273426.07172526506 262228.37672401575 236761.06056320173 278479.31323433464 230773.68009719593 230683.57127970306 230150.75753704397 238855.9616981501 267070.7178656106 0.8657049417466225 1.0237965206760422 0.9818686931300663 0.8865107431296132 1.0427175074074007 0.8640920350291668 0.863754638184567 0.8617596095010884 0.8943547372285938 1.0 18.026862279290754 -6.799855925146322 24.999941405036743 0.886087296684001 0.9607763871990886 0.1899483451620212 0.06348511599618298 226.61896143888268 147472.98655592726 0.021225211813322587 0.01871922341876927 1.5854190594576469e-07 6.799855925146322 0.07468909051508765 S(ph)SGNSSSSGSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 S(0.308)S(0.308)GNS(0.308)S(0.067)S(0.007)S(0.002)GSGSGSTSAGSSSPGAR 49.343 0.041915 112500.0 0.0 0.0 463.9 439.85 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 434.0531790561299 379.94167121642795 0.0 0.0 0.0 0.0 0.0 0.0 0.0 S(ph)SGPTSLFAVTVAPPGAR ddPTM_A459_Selumetinib_30min_R1 2 SSGPTSLFAVTVAPPGAR 18 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;A0A1W2PP22 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.99)S(0.01)GPTSLFAVTVAPPGAR;S(0.984)S(0.016)GPTSLFAVTVAPPGAR 247.02 9.047599999999999e-33 22340000.0 646.21 832.9200000000001 649.49 724.3499999999999 912.5 779.34 708.5699999999999 799.8499999999999 421.53999999999996 597.23 True False 661.2654356942257 735.4013391859976 561.2928253931967 597.855870233505 829.9645361149594 771.5005471841032 655.1219944270199 778.6353797210393 715.3225919365408 673.8902880128344 0.9812657155872705 1.0912775451246624 0.832914252330799 0.8871709251018598 1.231601865879914 1.144845920630644 0.9721493336234918 1.1554334489922342 1.06148226894007 1.0 9.396369923876977 -6.243574122686869 24.999188641907438 1.0984483702471226 0.9501483644366843 0.36544480516058164 0.09419960488166626 953.5111931471184 1334265.8399101933 0.028731409738145235 0.037019588459214096 5.707236602866003e-07 6.243574122686869 -0.14830000581043834 S(ph)SGPTSLFAVTVAPPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGPTSLFAVTVAPPGAR 18 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;A0A1W2PP22 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.964)S(0.036)GPTSLFAVTVAPPGAR 122.5 0.00090814 6231200.0 7823.5 9343.1 9929.5 9636.0 12195.0 8060.7 6033.9 8689.4 5173.4 12426.0 True False 7388.701189951912 10059.685727198465 9290.64678042217 8323.56017697283 10662.95507531675 9170.98825725081 6314.488305946025 8714.684715392386 6208.2245568734625 12067.229093374717 0.612294764007467 0.8336367569852091 0.7699072180143678 0.6897656547800789 0.8836291242014327 0.7599912280016269 0.5232757459964753 0.7221777798332359 0.5144697683979473 1.0 13.558806818510801 -7.050662497726833 24.99091438311445 0.6632295742528481 0.7652317464102447 0.03748784154650908 0.14366964210791855 824.8014890970119 406857.32750617125 0.051009548789595245 0.039512411743085625 8.898924092562726e-08 7.050662497726833 0.1020021721573966 S(ph)SGPYGGGGQYFAK ddPTM_A459_Selumetinib_30min_R2 1 SSGPYGGGGQYFAK 14 0 F8W6I7;P09651-2;P09651;P09651-3;Q32P51;H0YH80 F8W6I7 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 S(0.997)S(0.003)GPYGGGGQYFAK 161.49 0.00028276 4585400.0 14982.0 13375.0 16427.0 18086.0 17547.0 16240.0 21416.0 19138.0 16908.0 16528.0 True False 14149.360417697895 14400.81949259662 15370.104704365274 15622.655599909773 15342.58898782969 18476.912587958006 22411.88643499892 19193.688411533552 20290.072448992232 16050.793695098773 0.8815364951091799 0.8972029524617225 0.9575915681390041 0.9733260483361806 0.9558772780510325 1.1511525809219059 1.3963101676300627 1.195809302401942 1.2641164564458862 1.0 13.970357018434193 -6.823373672027068 3.4906736154055142 1.2352708117174809 0.9316531584307373 0.6661808529543716 0.09525034602406106 0.1298186542891873 3.191189122533998 0.033505902468976535 0.030110983283503624 1.501849201481647e-07 6.823373672027068 -0.3036176532867436 S(ph)SGPYGGGGQYFAKPR ddPTM_A459_Selumetinib_30min_R1 2 SSGPYGGGGQYFAKPR 16 1 F8W6I7;P09651-2;P09651;P09651-3;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.499)S(0.499)GPY(0.001)GGGGQYFAKPR;S(0.999)S(0.001)GPYGGGGQYFAKPR 260.73 1.9295e-38 110934000.0 3323.4 3873.7000000000003 4522.7 5223.5 4100.200000000001 3212.2400000000002 3426.2000000000003 3614.1000000000004 2066.52 2464.11 True False 3400.8287537893107 3420.1654031657295 3908.5421814128163 4311.313782238854 3729.337633949104 3179.927782080562 3167.7589755505537 3518.2423277487155 3506.733507350904 2780.40252096396 1.2231425946953358 1.2300972169957483 1.4057468844682721 1.5506077806116112 1.3412941492572632 1.1436933171021897 1.1393166822666734 1.265371578834905 1.2612323147136 1.0 11.44107804277679 -6.726006626673258 7.739020720785689 1.1771191476264231 1.3583577391143307 0.41478881377121257 0.11089005117338575 0.2486604264467513 44.864371732761185 0.039769644853995645 0.039287157719291727 1.879288141505743e-07 6.726006626673258 0.18123859148790755 S(ph)SGPYGGGGQYFAKPR ddPTM_A459_Selumetinib_30min_R2 1 SSGPYGGGGQYFAKPR 16 1 F8W6I7;P09651-2;P09651;P09651-3;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.5)S(0.5)GPYGGGGQYFAKPR 109.95 0.0015838 80566000.0 84039.0 75393.0 78252.0 89025.0 89674.0 54734.0 47315.0 58095.0 60106.0 77186.0 True False 79368.44881477203 81175.40067329608 73217.35151433549 76899.64142330918 78408.35042426852 62273.111674217565 49515.24125289384 58264.04683185498 72128.87950195925 74957.43962668761 1.0588468497597125 1.0829532208887596 0.9767856516842314 1.0259107275581232 1.046038269380165 0.8307795995215136 0.6605780760321566 0.777295050658465 0.9622644511496723 1.0 16.193784054251907 -6.771170740756047 8.706365692245933 0.8203554123427537 1.0366430228838264 0.5069566522740316 0.09290605240463679 0.11087993404554818 64.99225731057992 0.032469515551868444 0.029812006756932064 1.69367181073394e-07 6.771170740756047 0.2162876105410727 S(ph)SGREEDDEELLR ddPTM_A459_Selumetinib_30min_R2 2 SSGREEDDEELLR 13 1 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 S(0.985)S(0.015)GREEDDEELLR;S(0.868)S(0.132)GREEDDEELLR 177.21 0.00049062 41887000.0 18026.0 17012.1 19311.6 22505.0 26423.0 20930.8 18440.8 20949.0 12017.1 24180.0 True False 17024.187083795376 18316.873367476852 18069.112680880284 19439.7801767096 23103.506515382902 23813.82770911525 19298.333739751983 21009.95812170636 14420.855785828286 23481.86057281511 0.7249931082336906 0.7800435280959913 0.7694923758213116 0.8278637085178414 0.9838873901725561 1.0141371734693143 0.8218400616045568 0.8947314058252069 0.6141274768713717 1.0 14.519259103705618 -5.920385318366131 3.8360693902983996 0.8872967606714284 0.7607664629420446 0.22005808889530243 0.10917243183467529 0.3722049429294596 10.726360414090813 0.032536217567986414 0.049717079675386876 1.2011982246115857e-06 5.920385318366131 -0.12653029772938373 S(ph)SGRNSPSAASTSSNDSK ddPTM_A459_Selumetinib_30min_R1 1 SSGRNSPSAASTSSNDSK 18 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 S(0.487)S(0.487)GRNS(0.026)PS(0.001)AASTSSNDSK 120.59 0.0005225 12985000.0 1571.7 1619.2 1369.8 1544.1 1677.2 1221.9 1429.7 1434.5 781.5 1191.1 True False 1608.3175520041693 1429.623311254343 1183.788683772808 1274.4519213468006 1525.4975561337105 1209.6087953964334 1321.8565779419262 1396.4524000873043 1326.1484214983304 1343.989287296497 1.1966743836473446 1.0637162995027314 0.8808021722807474 0.9482604760268779 1.1350518717320484 0.9000137179884992 0.9835320790397877 1.0390353653014153 0.9867254404727777 1.0 10.392305923354792 -4.887132013232158 3.6884914167426164 0.985827974454307 1.1988817233904259 0.4807131095192285 0.0676160799195554 0.20871890966889778 4.859422109217949 0.01721560033968236 0.10062246788042417 1.2967850251180022e-05 4.887132013232158 0.21305374893611884 S(ph)SGRNSPSAASTSSNDSK ddPTM_A459_Selumetinib_30min_R2 2 SSGRNSPSAASTSSNDSK 18 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 S(0.456)S(0.456)GRNS(0.086)PS(0.002)AASTSSNDSK;S(0.273)S(0.273)GRNS(0.227)PS(0.227)AASTSSNDSK 107.21 0.0008832000000000002 37888900.0 14511.800000000001 12758.7 12544.2 13404.4 14974.0 9193.0 11782.8 11255.6 10308.400000000001 16166.9 True False 13705.292251338164 13737.251264313461 11737.119829092284 11578.697596120239 13092.83225074154 10459.252304254796 12330.723547175261 11288.35193253511 12370.368040761281 15700.119590349248 0.8729419016503995 0.8749774920668536 0.747581555767703 0.7374910445419526 0.8339320076765282 0.666189339773184 0.7853904217872881 0.7189978310403431 0.7879155295329889 1.0 13.93848792794958 -5.253485446616152 23.490856247781338 0.7705176367206916 0.873959735971848 0.13345813615717772 0.0850676211656817 397.03210259738165 1172561.0993953052 0.019897744747281645 0.05047285093853067 5.578462954831114e-06 5.253485446616152 0.10344209925115633 S(ph)SGSEGSSPNWLQALK ddPTM_A459_Selumetinib_30min_R1 1 SSGSEGSSPNWLQALK 16 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.813)S(0.104)GS(0.083)EGSSPNWLQALK 109.35 0.0029851 11860000.0 610.73 844.17 933.35 881.97 645.01 638.99 872.5 723.94 487.08 633.38 True False 624.9588207262876 745.3341839560143 806.6061965245652 727.9504961273481 586.6689593857645 632.5623407564998 806.6866225462201 704.7387595114697 826.5391850843342 714.6804926436532 0.8744590445088561 1.0428914621678995 1.1286248957780733 1.0185677426770223 0.820882849643251 0.8850980924589216 1.128737430011878 0.9860892619366055 1.1565156648209438 1.0 9.481154599916875 -8.216397762054495 23.77868361971744 1.0782579624314623 0.9893617889283268 0.1125836264688459 0.10356456872208647 535.5271052881216 282719.62265558896 0.07391485005373145 0.027936783856228293 6.0757827698496575e-09 8.216397762054495 -0.0888961735031355 S(ph)SGSEGSSPNWLQALK ddPTM_A459_Selumetinib_30min_R2 2 SSGSEGSSPNWLQALK 16 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.98)S(0.019)GS(0.001)EGSSPNWLQALK;S(0.981)S(0.019)GSEGSSPNWLQALK 183.76 8.5417e-07 7777500.0 36343.6 34411.1 41545.0 43189.0 40848.0 27498.5 30940.9 30922.6 25930.9 33035.5 True False 34323.768206958055 37050.320720874166 38872.03993077588 37306.583694819405 35716.30905424671 31286.168768470656 32379.713158230243 31012.57964648799 31117.80456988247 32081.679278462947 1.0698868942935997 1.1548747308170606 1.2116585167931477 1.1628625599989724 1.113293002658491 0.9752035888431085 1.0092898466187015 0.966675696035255 0.9699556030027535 1.0 14.969462039525053 -6.6715959202572 3.66901178514308 0.98292131031257 1.1532389624452066 0.8385989382624885 0.03492799389741919 0.09141121538533756 2.386500283980026 0.012816416863758963 0.012582475817199033 2.1301200475690376e-07 6.6715959202572 0.1703176521326366 S(ph)SGSETEQVVDFSDR ddPTM_A459_Selumetinib_30min_R2 1 SSGSETEQVVDFSDR 15 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 S(0.896)S(0.078)GS(0.026)ETEQVVDFSDR 273.44 3.1985e-45 16362000.0 14225.0 14093.0 14269.0 17739.0 16899.0 12045.0 10798.0 15002.0 11309.0 13556.0 True False 13434.431447186798 15173.887783862745 13350.948074912529 15322.917598518166 14775.996541023182 13704.089416376499 11300.128395831078 15045.653336285204 13571.115999861204 13164.60305728212 1.020496507849921 1.1526278246171024 1.014155004660572 1.1639483189766329 1.122403499500101 1.0409800703254746 0.8583721321988746 1.1428869728026143 1.0308792404002047 1.0 13.684376401053127 -6.962523354221609 8.078481327414776 1.0100726643952247 1.0960337974965897 0.21365136457785772 0.0788131875778118 0.3779302143823541 70.89973149186851 0.027732319714290663 0.024341025114540022 1.0901258692003173e-07 6.962523354221609 0.085961133101365 S(ph)SGSPEPSPAIAK ddPTM_A459_Selumetinib_30min_R2 1 SSGSPEPSPAIAK 13 0 Q66K64;K7ELE9 Q66K64 DCAF15 DDB1- and CUL4-associated factor 15 1 S(0.777)S(0.068)GS(0.155)PEPSPAIAK 174.72 0.0001162 18212000.0 138010.0 119270.0 147680.0 150270.0 158860.0 126670.0 136340.0 145360.0 120890.0 132410.0 True False 130339.9566978033 128417.62548650493 138178.4295818264 129802.96676979086 138902.58657358075 144117.6427042267 142680.08015258476 145782.97353435654 145071.37794882132 128586.97925750427 1.0136326201176915 0.9986829632986385 1.0745911474062595 1.0094565368850565 1.0802227984173947 1.120779440783201 1.1095997508959137 1.133730447485014 1.1281964844846841 1.0 16.97238503691854 -6.435461824896866 3.8470488771292515 1.1072256351908798 1.0261096856722074 0.4222736307918794 0.04054373444474591 0.20599458162205414 5.631585910023065 0.012556284247445551 0.014081590247063446 3.668919433480134e-07 6.435461824896866 -0.0811159495186724 S(ph)SGSPYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R1 5 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 S(0.583)S(0.064)GS(0.353)PYGGGYGSGGGSGGYGSR;S(0.477)S(0.046)GS(0.477)PYGGGYGSGGGSGGYGSR;S(0.637)S(0.078)GS(0.285)PYGGGYGSGGGSGGYGSR;S(0.496)S(0.008)GS(0.496)PYGGGYGSGGGSGGYGSR;S(0.478)S(0.045)GS(0.478)PYGGGYGSGGGSGGYGSR 324.71 5.507799999999997e-142 706318200.0 10957.640000000001 13671.01 14132.66 15505.68 13697.72 12357.189999999999 13590.61 11621.04 7361.700000000001 10326.230000000001 True False 11212.931692144157 12070.40179371988 12213.522397144556 12797.904065661978 12458.763644528884 12232.887888030817 12565.459345837111 11312.812268742131 12492.267222705388 11651.702206497961 0.9623427970799744 1.0359346282458557 1.0482178638528263 1.0983720523276677 1.0692655393802322 1.0498798949057193 1.078422630714812 0.9709149846305859 1.0721409628662375 1.0 13.508253114298714 -4.746004488949086 2.930188744316858 1.0507764249856446 0.9426256058346015 0.33838078406819583 0.03576842825290587 0.528735981779427 5.954735457842358 0.009130024872439005 0.14281519804398107 1.7947150762255706e-05 4.746004488949086 -0.10815081915104308 S(ph)SGSPYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R2 7 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 S(0.867)S(0.096)GS(0.037)PYGGGYGSGGGSGGYGSR;S(0.708)S(0.008)GS(0.284)PYGGGYGSGGGSGGYGSR;S(0.849)S(0.075)GS(0.075)PYGGGYGSGGGSGGYGSR;S(0.605)S(0.357)GS(0.037)PYGGGYGSGGGSGGYGSR;S(0.729)S(0.005)GS(0.266)PYGGGYGSGGGSGGYGSR;S(0.464)S(0.071)GS(0.464)PYGGGYGSGGGSGGYGSR;S(0.966)S(0.017)GS(0.017)PYGGGYGSGGGSGGYGSR 327.31 1.600699999999999e-144 268920000.0 187995.0 171827.0 215881.0 213322.0 215600.0 155901.0 153301.0 168911.0 143715.0 179853.0 True False 177546.99050361224 185005.57838911423 201991.45149346124 184267.17559902437 188514.40051154507 177374.94762162806 160429.80026016862 169402.50304527854 172462.01573260687 174660.17657578643 1.0165281747930284 1.0592316005637314 1.15648257922043 1.0550039465869279 1.079321023300049 1.0155431598608493 0.918525352518219 0.9698976971534977 0.9874146420421958 1.0 17.41419117825002 -6.942332230804767 3.740841430779418 0.9660595737033434 1.0758784432197246 0.6196484366793168 0.038453349716050265 0.15005804393033229 4.308686965650887 0.01486046762600846 0.012687785294846647 1.1420043789632534e-07 6.942332230804767 0.1098188695163812 S(ph)SIDSQASLSGPLSGGAPGAGAR ddPTM_A459_Selumetinib_30min_R1 1 SSIDSQASLSGPLSGGAPGAGAR 23 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(0.741)S(0.258)IDSQASLSGPLSGGAPGAGAR 74.703 0.009884100000000002 0.0 256.89 428.25 289.21 350.54 388.45 337.88 298.66 222.49 126.08 201.66 True False 262.8750371790745 378.1102909119765 249.93687051681547 289.32476945075297 353.3147660864175 334.48123397049415 276.1318357474546 216.588842450627 213.94855148113828 227.54502533474238 1.1552660261078354 1.6616943849057433 1.0984062171833129 1.2715055801599098 1.5527246335825393 1.4699562580128371 1.213526137700598 0.9518504837976673 0.9402471056723729 1.0 7.830008235745302 -7.610550014591785 3.384482416133323 0.9580431909229463 1.372427917554937 0.5538460017290951 0.1618567132736872 0.18080775317385436 4.103072310144616 0.08484501349817929 0.04553235598497981 2.4516021040578353e-08 7.610550014591785 0.41438472663199066 S(ph)SIDSQASLSGPLSGGAPGAGAR ddPTM_A459_Selumetinib_30min_R2 2 SSIDSQASLSGPLSGGAPGAGAR 23 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(0.5)S(0.5)IDSQASLSGPLSGGAPGAGAR;S(0.936)S(0.064)IDSQASLSGPLSGGAPGAGAR 464.59 0.0 29623000.0 46258.0 40207.0 48311.0 54045.0 57250.0 49172.0 48856.0 54951.0 41761.0 47872.0 True False 43687.16554544584 43290.747614118314 45202.72285703967 46683.97776717483 50057.74317850625 55944.996661026555 51127.900806327445 55110.89831237222 50114.3668998323 46489.81097360652 0.9397148456948594 0.9311878604689444 0.9723146192765213 1.0041765451289648 1.0767465414502402 1.2033818914167662 1.0997657279216317 1.1854403611935551 1.0779645227700223 1.0 15.50462693945677 -6.1506604379997585 1.9272681769017452 1.124807902729531 0.9443616046346245 0.6400535898833031 0.05457595593566845 0.19027928250462217 1.3939965918120425 0.017490305490954195 0.024894974428918637 7.068700190013408e-07 6.1506604379997585 -0.18044629809490653 S(ph)SIEDAQCPGLPDLIEENHVVNK ddPTM_A459_Selumetinib_30min_R1 2 SSIEDAQCPGLPDLIEENHVVNK 23 0 Q15398-1;Q15398;Q15398-3 Q15398-1 DLGAP5 Disks large-associated protein 5 1 S(0.5)S(0.5)IEDAQCPGLPDLIEENHVVNK;S(0.5)S(0.5)IEDAQCPGLPDLIEENHVVNK 188.38 2.4963e-22 28413000.0 3518.8 5102.0 4601.1 4966.5 4630.0 4272.7 5717.700000000001 4500.7 2670.3 4201.0 True False 3600.7811936070952 4504.655468144551 3976.29589203319 4099.194007751369 4211.217317492894 4229.720517301204 5286.409285653324 4381.326815666037 4531.304069004469 4740.239271205262 0.7596201346797318 0.9503012844748634 0.8388386460125185 0.8647652097758137 0.8883976264814458 0.8923010580910502 1.1152199252400168 0.9242838947562309 0.9559230683839154 1.0 12.210744167977387 -7.025430947469773 23.79407714190458 0.9941490025749393 0.8670186016415204 0.5138927809080208 0.06384468980713397 350.34646271528106 327795.0880221584 0.023387108990489968 0.01820566980568282 9.431245557084507e-08 7.025430947469773 -0.12713040093341887 S(ph)SIEDAQCPGLPDLIEENHVVNK ddPTM_A459_Selumetinib_30min_R2 4 SSIEDAQCPGLPDLIEENHVVNK 23 0 Q15398-1;Q15398;Q15398-3 Q15398-1 DLGAP5 Disks large-associated protein 5 1 S(0.5)S(0.5)IEDAQCPGLPDLIEENHVVNK;S(0.5)S(0.5)IEDAQCPGLPDLIEENHVVNK;S(0.5)S(0.5)IEDAQCPGLPDLIEENHVVNK;S(0.5)S(0.5)IEDAQCPGLPDLIEENHVVNK 151.12 1.3639999999999998e-09 7865200.0 35369.6 36568.4 42318.1 43451.100000000006 39792.9 34457.8 37865.2 38259.3 33678.3 44407.6 True False 33403.899227727125 39373.07869406134 39595.3995184635 37532.98522267167 34793.76014896037 39204.04917323521 39626.006828470374 38370.628228831905 40414.90105032505 43125.43720319871 0.7745753178184471 0.9129896703085703 0.918144883538169 0.8703212687635724 0.8068036501292476 0.9090701849238844 0.9188546110677164 0.8897446777881216 0.9371476249596696 1.0 15.396251462360995 -14.522878745280336 0.09436497124172145 1.4035406230345837 0.7899989390319033 0.497645073166021 0.04330454804241918 188.19786878386745 1.218450276102753 14.85975081641251 0.9142877973731558 3.0000000000000132e-15 14.522878745280336 -0.6135416840026804 S(ph)SISGSLPSSGSLQAVSSR ddPTM_A459_Selumetinib_30min_R1 1 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.987)S(0.012)IS(0.001)GSLPSSGSLQAVSSR 241.11 7.061799999999998e-30 5191600.0 1051.3 1130.5 1061.4 1020.6 725.9 996.84 938.21 815.84 429.83 776.93 True False 1075.7932445262982 998.1405344448091 917.2677098528675 842.3713690347417 660.2424731680542 986.8126946583034 867.4400643427957 794.2012729781998 729.3901164588962 876.6565334390633 1.2271547675644818 1.1385765078703884 1.0463250712961545 0.9608909953938024 0.7531370017605051 1.1256548682607828 0.9894867958605043 0.9059434826346445 0.8320135522147413 1.0 9.775867907517403 -5.32859141273445 1.7061610577509987 0.9365224820123308 1.219129269539928 0.5217312835967765 0.09490948044198953 0.3637919983485157 1.8696602193989031 0.028793181423891985 0.1166371110542135 4.692546525745554e-06 5.32859141273445 0.28260678752759727 S(ph)SISGSLPSSGSLQAVSSR ddPTM_A459_Selumetinib_30min_R2 1 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.519)S(0.481)ISGSLPSSGSLQAVSSR 161.1 1.5144e-06 2491500.0 11457.0 6798.1 6900.7 11056.0 9585.6 5115.3 9366.0 7445.1 7171.2 6501.0 True False 10820.265806004865 7319.492410663258 6456.716474914076 9550.153727336203 8381.371231648725 5819.8861429298995 9801.537558376913 7466.764008397349 8605.64038006938 6313.299238373494 1.7138845154427544 1.159376759171167 1.022716686018756 1.512704113451246 1.327573890479494 0.9218454445427628 1.5525222531511274 1.182703959763679 1.3630971786926525 1.0 12.624178418383963 -4.755555419171373 24.98319573309907 1.238990216207442 1.7138852920418328 0.34068611054393794 0.2025954380101398 224.92026812239047 954911.4863341297 0.04863533842369218 0.42688529426626703 1.7556768426209723e-05 4.755555419171373 0.47489507583439083 S(ph)SITEPEGPGGPNIQK ddPTM_A459_Selumetinib_30min_R1 1 SSITEPEGPGGPNIQK 16 0 Q96KQ4;A0A3B3ISJ2;H0YJL1 Q96KQ4 PPP1R13B Apoptosis-stimulating of p53 protein 1 1 S(0.657)S(0.332)IT(0.011)EPEGPGGPNIQK 296.25 1.306799999999999e-75 4963900.0 1174.1 1455.2 1318.6 920.8 1204.4 1402.0 1236.7 1240.6 718.47 1187.9 True False 1201.4542455990932 1284.8245074958736 1139.541362551339 759.9995655567221 1095.4622326540905 1387.8971529141495 1143.4147233271178 1207.6952579632698 1219.1911150273913 1340.3785361258579 0.8963544351222585 0.958553477892481 0.8501638394218058 0.567003682223512 0.8172782562009256 1.0354516395984945 0.8530535908400687 0.9010105917197935 0.909587166735198 1.0 10.388424774203774 -6.627110055257758 13.744942940389137 0.928185896758541 0.8130874304131397 0.24298904649826136 0.10649803201837821 1.1201094833115695 140.77953921593448 0.03824500306470883 0.038242546244070856 2.3598801364099012e-07 6.627110055257758 -0.11509846634540133 S(ph)SITEPEGPGGPNIQK ddPTM_A459_Selumetinib_30min_R2 2 SSITEPEGPGGPNIQK 16 0 Q96KQ4;A0A3B3ISJ2;H0YJL1 Q96KQ4 PPP1R13B Apoptosis-stimulating of p53 protein 1 1 S(0.586)S(0.412)IT(0.002)EPEGPGGPNIQK;S(0.849)S(0.151)ITEPEGPGGPNIQK 181.75 9.5169e-07 23980000.0 143802.0 102034.0 124541.0 143810.0 138523.0 115897.0 149667.0 156343.0 140899.0 112071.0 True False 135810.0605250163 109859.67970897988 116528.1676499884 124222.82991391249 121120.50232866757 131860.7597417838 156626.8120595342 156797.93224602312 169082.7370469933 108835.21903457229 1.247850298182202 1.0094129518320918 1.0706843674653919 1.1413844802797908 1.1128796671065895 1.211563323999902 1.4391188206253396 1.4406911075009197 1.55356637811592 1.0 16.731785962132918 -7.064759234030214 3.226001226892373 1.3943771634773472 1.1105655104988823 0.362652690738301 0.1475212160348728 0.2321768750485163 4.743402026567744 0.056543848036214574 0.04404192793805979 8.614712057934865e-08 7.064759234030214 -0.2838116529784649 S(ph)SITEPEGPNGPNIQK ddPTM_A459_Selumetinib_30min_R1 2 SSITEPEGPNGPNIQK 16 0 Q13625-2;Q13625;Q13625-3 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 S(0.761)S(0.239)ITEPEGPNGPNIQK;S(0.946)S(0.054)ITEPEGPNGPNIQK 297.97 6.8328e-88 22047700.0 5756.1 4475.6 4108.6 4195.9 4628.5 3965.7 4745.799999999999 5345.1 3082.55 4931.9 True False 5890.205930579117 3951.5946713500084 3550.674686924338 3463.1648317978397 4209.852992228048 3925.8086585675046 4387.8204851345 5203.330584668285 5230.862209455765 5564.957405774152 1.0584458246648016 0.7100853399614286 0.6380416646568019 0.6223165029447466 0.7564932999954215 0.7054516993237215 0.7884733278608269 0.935017144833733 0.9399644647824739 1.0 12.442154929872885 -7.729443440013528 2.661865199576092 0.9647739568310344 0.7361154397703089 0.40441902261353857 0.11422910907342972 0.2841689317043325 4.050095624945848 0.07236260750556572 0.03334050832499699 1.8644749808150067e-08 7.729443440013528 -0.22865851706072549 S(ph)SITEPEGPNGPNIQK ddPTM_A459_Selumetinib_30min_R2 3 SSITEPEGPNGPNIQK 16 0 Q13625-2;Q13625;Q13625-3 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 S(0.667)S(0.329)IT(0.003)EPEGPNGPNIQK;S(0.69)S(0.31)ITEPEGPNGPNIQK;S(0.939)S(0.061)ITEPEGPNGPNIQK 333.66 7.238499999999997e-135 89482800.0 197161.0 164780.0 166314.0 215221.0 180235.0 172665.0 240882.0 235137.0 201386.0 122195.0 True False 186203.58091801734 177418.09614879015 155613.5383089913 185907.5285230665 157592.26797865628 196448.03645318773 252083.4902986278 235821.20974097442 241668.82719498166 118666.91284926163 1.569128044601153 1.4950932141814295 1.3113473214447033 1.5666332262238778 1.3280219750794406 1.6554575469805024 2.124294668547083 1.9872532627568202 2.0365308357011442 1.0 16.85655820787958 -7.00393613425113 7.495062540852001 1.872758408002585 1.457580688526961 0.19108502181441034 0.3047754981204479 0.15811774387670705 64.0861628066003 0.10454920706871168 0.08730370909051506 9.909776637077855e-08 7.00393613425113 -0.4151777194756239 S(ph)SLAELMAR ddPTM_A459_Selumetinib_30min_R1 2 SSLAELMAR 9 0 Q9ULE0 Q9ULE0 WWC3 Protein WWC3 1 S(0.5)S(0.5)LAELMAR;S(0.5)S(0.5)LAELMAR 136.52 0.0026332 11342200.0 3899.4 4843.5 4102.799999999999 4587.0 4071.6000000000004 4201.4 4580.9 3697.1 2495.8 3769.2999999999997 True False 3990.248433088412 4276.420768317937 3545.6622950672154 3785.9665586540877 3703.324498899364 4159.1377305659835 4235.359024896249 3599.0408981267174 4235.190313980214 4253.126371091164 0.9381918346490821 1.005477005664611 0.8336602267845512 0.8901608436531774 0.8707299468153951 0.9779012819454345 0.9958225209775845 0.8462106657798091 0.9957828534715397 1.0 12.054308006364064 -6.772731710484108 24.998922285861816 0.9555740709743284 0.9079976434723318 0.17349510271387147 0.05942744455629776 491.75657666079127 1088642.5222325432 0.02151732676902386 0.019144548198064323 1.687595231324198e-07 6.772731710484108 -0.04757642750199664 S(ph)SLAELMAR ddPTM_A459_Selumetinib_30min_R2 1 SSLAELMAR 9 0 Q9ULE0 Q9ULE0 WWC3 Protein WWC3 1 S(0.929)S(0.071)LAELMAR 153.1 0.0010364 1392000.0 11660.0 9958.9 10792.0 11822.0 12583.0 10534.0 9236.3 11509.0 8357.8 12375.0 True False 11011.983878678244 10722.715607089385 10097.654469441173 10211.823205912498 11002.21104655274 11984.962881868829 9665.806251381238 11542.489284582478 10029.59353644354 12017.701595888635 0.9163136387448282 0.8922434561661711 0.8402317522092305 0.8497317997483026 0.9155004356504156 0.9972757924001868 0.8042974086399348 0.9604573047920635 0.8345683620464296 1.0 13.55287338431083 -6.285908987547342 22.317559003426716 0.9149164415870411 0.8734312295458424 0.10568107353590073 0.062165617836526806 501.0247793879964 456958.093282037 0.018625924255470015 0.021137204284989077 5.177153150322897e-07 6.285908987547342 -0.041485212041198705 S(ph)SLETLEDIEENAPLR ddPTM_A459_Selumetinib_30min_R1 1 SSLETLEDIEENAPLR 16 0 V9GYB4;Q8TDN4-2;Q8TDN4 V9GYB4 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 S(0.757)S(0.043)LET(0.199)LEDIEENAPLR 374.19 4.663199999999996e-221 4629600.0 617.54 908.55 606.51 608.15 627.71 395.57 597.21 792.64 360.72 506.16 True False 631.9274804763344 802.176543626564 524.1492733209564 501.94801888935774 570.9337413312015 391.59092494882304 552.1619688834704 771.61661234242 612.115494053587 571.1305664159141 1.1064501142741259 1.404541432024136 0.9177398376875795 0.8788673700994395 0.9996553763775108 0.6856416868146661 0.9667876337778948 1.3510336474978752 1.0717610473816357 1.0 9.157676788230992 -5.272600373295124 24.942268390769 0.9820159063922883 1.2554957791594923 0.2876460292092312 0.17091890588390465 842.481280309962 1882754.6820407326 0.04843734450521253 0.10230185245942629 5.338258825171202e-06 5.272600373295124 0.273479872767204 S(ph)SLETLEDIEENAPLRR ddPTM_A459_Selumetinib_30min_R1 4 SSLETLEDIEENAPLRR 17 1 V9GYB4;Q8TDN4-2;Q8TDN4 V9GYB4 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 S(0.5)S(0.5)LETLEDIEENAPLRR;S(0.5)S(0.5)LETLEDIEENAPLRR;S(0.499)S(0.499)LET(0.003)LEDIEENAPLRR;S(0.497)S(0.497)LET(0.006)LEDIEENAPLRR 243.16 3.6685e-23 26665600.0 1672.7999999999997 1641.33 1904.1100000000001 1680.1100000000001 1552.66 1521.42 1618.73 1440.85 727.23 1554.78 True False 1711.772985297815 1449.1623205663843 1645.5423205275526 1386.710328070703 1412.2221771443867 1506.1158961388346 1496.627892853001 1402.6339774595972 1234.0561952223054 1754.3511578396858 0.9757299601327811 0.8260389113607608 0.9379777322083449 0.7904405693660003 0.8049826118525792 0.8585030935274504 0.8530948243542951 0.7995172295988937 0.7034259872703744 1.0 10.776721836873243 -5.761924077622068 24.99999691200751 0.8227496112708738 0.9045278755328253 0.18353031479199178 0.07880571930907082 21.28534326339321 1097970.708716878 0.020853396052818846 0.03320093495114054 1.7301187882283172e-06 5.761924077622068 0.08177826426195156 S(ph)SLETLEDIEENAPLRR ddPTM_A459_Selumetinib_30min_R2 2 SSLETLEDIEENAPLRR 17 1 V9GYB4;Q8TDN4-2;Q8TDN4 V9GYB4 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 S(0.5)S(0.5)LET(0.001)LEDIEENAPLRR;S(0.5)S(0.5)LETLEDIEENAPLRR 180.32 4.0068e-08 9147500.0 6285.299999999999 3744.9 3746.3500000000004 6298.4 4756.9 4392.0599999999995 5180.2 5326.799999999999 2191.2 5221.0 True False 5935.988188049434 4032.121788248607 3505.313919717467 5440.54705465397 4159.295694774437 4997.026397848943 5421.089564371567 5342.300106100784 2629.5012272434237 5070.256164212892 1.1707471961568905 0.7952501131418781 0.6913484853997772 1.073031988611282 0.820332456598892 0.9855569888399677 1.0691944132201727 1.0536548712879725 0.518613092135874 1.0 12.307842922917061 -12.112303234693421 2.2358281066531456 2.8215546715687254 0.9123987846639708 0.01964379980881159 0.19198115595118292 24611387.966375533 3588163.764202142 222668764.010962 0.04636855699445907 7.721412695138091e-13 12.112303234693421 -1.9091558869047547 S(ph)SLGQSASETEEDTVSVSK ddPTM_A459_Selumetinib_30min_R2 1 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 S(0.426)S(0.101)LGQS(0.044)AS(0.414)ETEEDT(0.014)VS(0.001)VSK 123.54 0.00041214 5221300.0 15058.0 13359.0 16060.0 18066.0 17330.0 13953.0 13259.0 15355.0 14127.0 12687.0 True False 14221.13664195 14383.59234404474 15026.717084805896 15605.379634411696 15152.850467834294 15874.899097276986 13875.569772210067 15399.680507842902 16952.794741359914 12320.693345215275 1.1542480803219373 1.1674336777183558 1.2196324235795952 1.266599143178255 1.2298699467038423 1.2884744918549558 1.1262003998824162 1.2499037250873017 1.3759610978341175 1.0 13.58879582531909 -11.752805666099457 2.4226101269843183 0.1744665238733736 1.22891419857244 0.5049180118524217 0.06857332733192605 4388070.07540101 1087519.5356396998 19819599.540552456 0.01777508495718114 1.7668282470675664e-12 11.752805666099457 1.0544476746990665 S(ph)SLGSHQLPR ddPTM_A459_Selumetinib_30min_R2 2 SSLGSHQLPR 10 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 S(0.592)S(0.407)LGSHQLPR;S(0.493)S(0.493)LGS(0.014)HQLPR 122.34 0.0029728000000000003 22814800.0 77673.6 74625.5 98442.0 117658.0 121631.0 80407.0 97222.0 89555.0 91695.0 118976.0 True False 73356.81226405686 80349.03589119787 92108.3488955455 101632.77742862917 106350.6263850637 91482.33438792726 101743.01564173821 89815.59022337158 110036.56217236457 115540.85374322807 0.6348993441495697 0.6954166711435363 0.7971929054656481 0.87962633247018 0.9204590665515745 0.7917747828939605 0.8805804383949468 0.7773491999892352 0.9523606465372331 1.0 16.818043534488616 -5.294992899408537 1.8177701989608217 0.8744581592270613 0.6350760363995807 0.6549415012950824 0.06393801144105371 0.2532703842001169 1.4825684826541332 0.017636176954951215 0.071878799297364 5.069989974965901e-06 5.294992899408537 -0.23938212282748061 S(ph)SLGSLQTPEAVTTR ddPTM_A459_Selumetinib_30min_R1 1 SSLGSLQTPEAVTTR 15 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 S(0.87)S(0.13)LGSLQTPEAVTTR 246.38 7.919399999999998e-28 28372000.0 1467.6 1594.4 1339.3 1646.1 1341.6 1045.5 1348.8 1142.3 508.69 1141.7 True False 1501.792224547508 1407.7269067835493 1157.4304162482993 1358.6395361239352 1220.2525168787172 1034.9832192380477 1247.0589300748893 1112.0024932866709 863.2097767523815 1288.2483160997488 1.165763002193767 1.0927450004712829 0.8984528850404332 1.0546410339873762 0.9472184062876223 0.8034035102576522 0.9680268271962017 0.863189557005071 0.6700647429261172 1.0 10.331194991372994 -3.9909729879109235 0.42895635722487363 0.8493954256412067 1.6889344441050826 0.48980722099670515 0.0986185920381149 8.598315881365561 0.7359571371398159 0.07007608711029507 4.229288221471864 0.00010210029857024709 3.9909729879109235 0.8395390184638759 S(ph)SLGSLQTPEAVTTR ddPTM_A459_Selumetinib_30min_R2 2 SSLGSLQTPEAVTTR 15 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 S(0.982)S(0.018)LGSLQTPEAVTTR;S(0.985)S(0.015)LGSLQTPEAVTTR 254.89 1.207e-28 28198000.0 96649.0 86543.0 100605.0 111386.0 114661.0 118444.0 90962.0 101128.0 71100.0 108414.0 True False 91277.63549660145 93180.56982039538 94132.18383044205 96215.03464843267 100256.26009765429 134758.58587241976 95191.91323778364 101422.26573735836 85321.98669998499 105283.8061265997 0.8669674744361315 0.885041805083959 0.8940803651916968 0.9138635673252336 0.9522476797343365 1.279955492019141 0.9041458201398898 0.9633225608827441 0.8103999070606225 1.0 16.68392402459444 -6.293766358394474 3.982262313259026 0.9954340085002993 0.8883731393625882 0.14863823309349045 0.1124780623393355 0.4453038995721919 15.83837961328844 0.037116089702251436 0.044274665532109084 5.084328955633196e-07 6.293766358394474 -0.10706086913771107 S(ph)SLPNGEGLQLK ddPTM_A459_Selumetinib_30min_R1 2 SSLPNGEGLQLK 12 0 Q9ULR3 Q9ULR3 PPM1H Protein phosphatase 1H 1 S(0.884)S(0.116)LPNGEGLQLK;S(0.779)S(0.221)LPNGEGLQLK 115.37 0.0052724 10564200.0 3357.0 4385.1 3002.4 2775.5 3470.1000000000004 3553.5 3636.6 3539.7 1992.25 3260.8 True False 3435.211568415089 3871.6904534223163 2594.690571002684 2290.811027587622 3156.230067695914 3517.7550163198484 3362.288334156543 3445.8156574339705 3380.702741817084 3679.3554428817242 0.933644933669301 1.0522741043985553 0.7052024767062148 0.6226120479932283 0.8578214626700782 0.9560791478098382 0.9138253659785449 0.9365269843935377 0.9188301576999228 1.0 11.845237338769321 -6.650433828086754 5.363450491791553 0.9386284000755705 0.8248737671571639 0.1990527214967457 0.11140275261959093 0.41112895940254696 17.788110804697954 0.04180344825324831 0.041604568749052155 2.2364859382107409e-07 6.650433828086754 -0.1137546329184066 S(ph)SLQQENLVEQAGSSSLVNGR ddPTM_A459_Selumetinib_30min_R1 2 SSLQQENLVEQAGSSSLVNGR 21 0 Q8N3F8 Q8N3F8 MICALL1 MICAL-like protein 1 1 S(0.788)S(0.212)LQQENLVEQAGSSSLVNGR;S(0.819)S(0.181)LQQENLVEQAGSSSLVNGR 133.92 4.1709e-05 13899300.0 1875.54 1776.12 1591.17 1615.24 2328.29 2749.3 2125.4 2231.01 1338.62 1415.82 True False 1919.236432834448 1568.1710447042142 1375.0978536711768 1333.168655809991 2117.696580592985 2721.6445381646736 1965.0793668306428 2171.8363674581947 2271.5403710634623 1597.554288254662 1.2013591318585022 0.9816073583436409 0.860751877905495 0.8345060106010457 1.3255866145910957 1.7036319567819427 1.2300548289833106 1.3594757833431372 1.4218861842530148 1.0 10.641649242479115 -6.329800695134087 6.63559204701476 1.3731396743311386 0.9632837084877406 0.47547923673736037 0.1889554171366493 0.19780262401216336 15.957895690129988 0.058329400883445195 0.06637268595588532 4.6794984188161657e-07 6.329800695134087 -0.409855965843398 S(ph)SLS(ph)GDEEDELFK ddPTM_A459_Selumetinib_30min_R1 2 SSLSGDEEDELFK 13 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 2 S(0.992)S(0.008)LS(1)GDEEDELFK;S(0.986)S(0.094)LS(0.919)GDEEDELFK 145.52 0.011374 3363400.0 1825.56 2462.7 2609.2 2812.6 1953.6999999999998 2274.5 2290.39 2014.83 1462.9299999999998 1831.87 True False 1868.091996078599 2174.365939121832 2254.884971309687 2321.4322090408727 1776.9881799537502 2251.620595080766 2117.624038296433 1961.3901633097978 2482.4853618202856 2067.0083584248478 0.9037660580638234 1.0519386292074773 1.0908930107220318 1.1230879640999165 0.8596908535521812 1.089313734946191 1.0244874093833642 0.9489028698483175 1.2010040267626445 1.0 11.013328507307255 -8.247263273428574 24.992295513243967 1.10050204249761 1.0171884431569373 0.1265922641652173 0.09254423085219082 1492.7349624012359 2631686.802162764 0.06136403119948506 0.022928648364652693 5.658961334404062e-09 8.247263273428574 -0.08331359934067262 S(ph)SLSGDEEDELFK ddPTM_A459_Selumetinib_30min_R1 1 SSLSGDEEDELFK 13 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 S(0.95)S(0.05)LSGDEEDELFK 329.46 2.0528999999999995e-120 89270000.0 2808.2 2770.1 3533.0 3492.3 2448.5 2725.9 2900.3 3086.2 1874.9 2324.1 True False 2873.6255961940005 2445.7754042154465 3053.238005379858 2882.435363590074 2227.0336073177855 2698.4799209191738 2681.5280359550734 3004.3439506095797 3181.5683627219705 2622.420873651072 1.0957911542982757 0.9326403052955835 1.1642822233675176 1.0991505568581736 0.8492281424747785 1.0290033716678775 1.0225391594834699 1.1456375979904303 1.2132180591944512 1.0 11.356683527659715 -7.758709194676921 24.80962400123465 1.1345708908476204 1.025084962820036 0.15423688712103245 0.09683573882246753 103.86733129163714 943890.4971552321 0.04812410158392694 0.02616976691889334 1.7429735848182738e-08 7.758709194676921 -0.10948592802758439 S(ph)SLSGDEEDELFK ddPTM_A459_Selumetinib_30min_R2 1 SSLSGDEEDELFK 13 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 S(0.993)S(0.007)LSGDEEDELFK 177.42 0.00010393 1394700.0 18202.0 14671.0 14373.0 19288.0 15586.0 9875.3 14341.0 16303.0 11243.0 16293.0 True False 17190.40570837919 15796.218525299822 13448.256828139167 16660.941126344132 13627.94733939211 11235.532935952084 15007.88491615239 16350.439030893058 13491.914155667118 15822.5787557021 1.0864477891875972 0.9983340117430114 0.8499409000124407 1.0529851918316353 0.8612974882163823 0.7100949288625314 0.948510678813584 1.0333612038430038 0.8527000790440015 1.0 13.94969712821449 -4.978403061744138 3.6088122638106115 0.9118605901587808 1.0809505852006729 0.2404050638395009 0.09735717477276623 0.34249838229509977 9.279250017150463 0.025857498299512185 0.12027722752695888 1.050986017786015e-05 4.978403061744138 0.16908999504189204 S(ph)SLVDEHPEDAEFEQK ddPTM_A459_Selumetinib_30min_R2 1 SSLVDEHPEDAEFEQK 16 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 S(0.5)S(0.5)LVDEHPEDAEFEQK 122.97 0.00092839 1893100.0 8704.0 6949.5 8316.7 11072.0 7861.8 6191.9 9481.8 9088.9 10136.0 9473.7 True False 8220.266524872679 7482.504303835533 7781.612576538299 9563.974499734668 6874.130398616254 7044.778020528152 9922.722487830266 9115.347194251603 12163.4832235028 9200.169665371328 0.8934907533078522 0.8133006863991928 0.8458118556038853 1.039543274482499 0.7471743075010788 0.7657226199908149 1.0785369018985125 0.9907803362106473 1.322093359787172 1.0 13.167444751607041 -7.330362488267088 6.66098123820181 1.0994093156503326 0.853008473699245 0.5327124105912125 0.11335687327877875 0.20680896277558858 16.634873114029972 0.04757712804381797 0.03195125091568516 4.6734490431693284e-08 7.330362488267088 -0.24640084195108758 S(ph)SLYEGLEKPESR ddPTM_A459_Selumetinib_30min_R2 1 SSLYEGLEKPESR 13 1 P20020-6;P20020;P20020-4;P20020-1;A0A0U1RQU3;E7ERY9;H0YHH6;A0A2R8Y4R4;Q01814-6;Q01814-8;Q01814-5;Q01814 P20020-6;Q01814-6 ATP2B1;ATP2B2 Plasma membrane calcium-transporting ATPase 1;Calcium-transporting ATPase;Plasma membrane calcium-transporting ATPase 2 1 S(0.496)S(0.496)LY(0.007)EGLEKPESR 62.077 0.047916 2811400.0 15844.0 8843.6 9863.6 13603.0 8589.6 7224.4 13954.0 10466.0 7758.4 9646.5 True False 14963.453908557292 9521.875683344117 9228.98671467568 11750.247933516135 7510.4976560017 8219.495523426347 14602.88864932644 10496.454327260435 9310.296787808224 9367.980480383003 1.5972977249356441 1.0164277886021835 0.9851628890561438 1.2542989343457445 0.8017200368562937 0.8774031436805789 1.5588086119420919 1.1204607384954004 0.9938424623433437 1.0 13.193522354429057 -4.75746605276371 24.946774450866368 1.075694612665234 1.5972985015268033 0.38304154717263583 0.20145031006806513 129.23604026748185 811300.7752920324 0.051717787955737206 0.38324579718119395 1.7479698895923017e-05 4.75746605276371 0.5216038888615693 S(ph)SLYGIAK ddPTM_A459_Selumetinib_30min_R2 2 SSLYGIAK 8 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.987)S(0.013)LYGIAK;S(0.921)S(0.079)LYGIAK 117.53 0.0088168 16686800.0 154974.0 128255.0 150828.0 166198.0 155455.0 136221.0 177302.0 163423.0 141859.0 136139.0 True False 146361.16549007563 138091.7460951758 141123.89068910942 143561.5456924586 135925.35311466717 154984.20625888108 185546.89431724785 163898.53387386608 170234.76387163388 132208.31333839873 1.1070496385159339 1.044501231490019 1.067435830059268 1.0858738158545316 1.0281150230451421 1.1722727742708998 1.4034434721387328 1.239699151553 1.2876252602656169 1.0 17.012453371668123 -6.974379824095891 5.9110629503646015 1.2576867254026762 1.0685007234307962 0.3905690917501532 0.09642551875044059 0.14669113861739388 16.049725232238107 0.032658367960954615 0.028135756622830632 1.0607674282830582e-07 6.974379824095891 -0.18918600197188007 S(ph)SMEMEGIFNHK ddPTM_A459_Selumetinib_30min_R1 4 SSMEMEGIFNHK 12 0 E7EPJ7;O75962-5;O75962-4;O75962;E7EWP2;O75962-2 E7EPJ7 TRIO Triple functional domain protein 1 S(0.576)S(0.424)MEMEGIFNHK;S(0.619)S(0.381)MEMEGIFNHK;S(0.5)S(0.5)MEMEGIFNHK;S(0.5)S(0.5)MEMEGIFNHK 195.94 0.00010951 67727000.0 14405.3 17752.2 18512.4 19154.500000000004 17591.6 16190.6 17558.0 16911.6 9675.8 14797.6 True False 14740.915462165598 15673.764171226121 15998.517761334302 15809.526149496338 16000.442886049233 16027.737263888603 16233.58592397311 16463.049431381296 16419.12590752853 16697.016100830046 0.8828472927826184 0.9387164794341274 0.9581662774188126 0.9468473920145775 0.9582815749488207 0.9599162609115427 0.9722447307915157 0.9859875160905476 0.9833568949312027 1.0 14.027302683376359 -1.5228787452803376 0.29050774752536734 0.9898029385459878 0.24116372633861247 0.8699115321556123 0.011138508876433625 19.682399494725228 0.2793739401502328 0.01255221609991233 7.57365379498499 0.029999999999999995 1.5228787452803376 -0.7486392122073753 S(ph)SMEMEGIFNHK ddPTM_A459_Selumetinib_30min_R2 4 SSMEMEGIFNHK 12 0 E7EPJ7;O75962-5;O75962-4;O75962;E7EWP2;O75962-2 E7EPJ7 TRIO Triple functional domain protein 1 S(0.5)S(0.5)MEMEGIFNHK;S(0.5)S(0.5)MEMEGIFNHK;S(0.5)S(0.5)MEMEGIFNHK;S(0.5)S(0.5)MEMEGIFNHK 189.99 8.8209e-05 25453400.0 117514.0 113442.0 136789.0 144214.0 133258.0 101436.0 114424.0 120301.0 96067.0 131439.0 True False 110983.04232581428 122142.63662647818 127988.14466460198 124571.80441697358 116516.93869836489 115407.88825567163 119744.9427268546 120651.05599309727 115283.08433625122 127644.01455046512 0.86947314150744 0.9569006197167834 1.002696014500553 0.9759314203309007 0.9128272806892873 0.9041386598667669 0.9381163946352725 0.9452151471262045 0.9031609099905982 1.0 16.961766363291773 -6.266334826140061 24.831181721728623 0.9298922699935809 0.9553285868657377 0.03192715748104613 0.04114404921294331 1108.5066367345594 5622671.171478823 0.012814719983756865 0.014966857660890887 5.415831873552648e-07 6.266334826140061 0.02543631687215686 S(ph)SMSGLHLVK ddPTM_A459_Selumetinib_30min_R1 1 SSMSGLHLVK 10 0 Q13085;A0A0C4DGT1;Q13085-4;Q13085-2 Q13085 ACACA Acetyl-CoA carboxylase 1;Biotin carboxylase 1 S(0.336)S(0.336)MS(0.328)GLHLVK 93.667 0.024898 18616000.0 1227.5 1476.5 1537.9 1672.4 1739.0 1591.8 1438.9 1748.0 928.36 1161.2 True False 1256.098361700782 1303.630693593773 1329.0616270800122 1380.3467348360793 1581.7077570453862 1575.787937238762 1330.3626145349633 1701.6373616957899 1575.3591152683189 1310.2513310458341 0.9586697849016284 0.9949470477188704 1.0143562502769325 1.0534976779869367 1.2071788973363433 1.2026608177386686 1.0153491799722703 1.2987106529688117 1.2023335355140432 1.0 10.355627859230168 -6.022736908684202 2.913375892870569 1.1644701059703222 0.9898295590991888 0.42643277032492566 0.08614566396165965 0.24205199226218413 4.149320943451973 0.025969353202021265 0.03794558278964586 9.48993179917571e-07 6.022736908684202 -0.1746405468711334 S(ph)SPAAFINPPIGTVTPALK ddPTM_A459_Selumetinib_30min_R1 2 SSPAAFINPPIGTVTPALK 19 0 F6VRR5;Q9BY77-2;Q9BY77;Q6R954;F8WEE2;Q8WUT1;F8WCX5 F6VRR5 POLDIP3;PDIP46 Polymerase delta-interacting protein 3 1 S(0.5)S(0.5)PAAFINPPIGTVTPALK;S(0.5)S(0.5)PAAFINPPIGTVTPALK 195.89 3.3456e-15 18301000.0 3383.9 5119.8 4753.4 4558.1 4630.1 3941.9 4403.700000000001 4027.6 1754.32 3208.2 True False 3462.7382860768016 4520.371435869556 4107.914388557208 3762.1134011339004 4211.308272510549 3902.2480649588365 4071.5253635607883 3920.7749645114195 2976.952909536729 3620.0037205143344 0.9565565544735992 1.2487201077316286 1.134781813973813 1.0392567775039123 1.1633436310148877 1.07796797081866 1.1247296074552933 1.0830858936118306 0.8223618369966095 1.0 11.821775464723281 -8.143851586402878 6.010772650531438 0.913498453644491 1.1108637039667635 0.46402910002242315 0.0827881675318687 0.17890380529364558 7.94136909231162 0.053883033330780955 0.01982150600619943 7.180396285755643e-09 8.143851586402878 0.19736525032227248 S(ph)SPAAFINPPIGTVTPALK ddPTM_A459_Selumetinib_30min_R2 2 SSPAAFINPPIGTVTPALK 19 0 F6VRR5;Q9BY77-2;Q9BY77;Q6R954;F8WEE2;Q8WUT1;F8WCX5 F6VRR5 POLDIP3;PDIP46 Polymerase delta-interacting protein 3 1 S(0.839)S(0.161)PAAFINPPIGTVTPALK;S(0.5)S(0.5)PAAFINPPIGTVTPALK 193.3 3.1596e-15 16840000.0 59144.0 52089.0 60654.0 64880.0 68215.0 52554.0 63374.0 57997.0 56116.0 60972.0 True False 55857.01325219093 56084.05880746656 56751.58767508195 56043.23207575728 59645.2218501626 59792.83646228728 66321.01657319865 58165.76166807976 67340.76801204456 59211.579935718924 0.943346104137573 0.9471805830608192 0.9584542033280047 0.9464910771946762 1.0073235997910281 1.0098166022119217 1.1200683488803684 0.9823376057728146 1.137290511166073 1.0 15.853591729088002 -6.615249820727648 1.6171026681534286 1.0580260667894372 0.9480553562845144 0.5286524478505579 0.04556227099193454 0.2786611527271452 1.4998331491975407 0.01723342400216861 0.01759779733483403 2.4252146291024176e-07 6.615249820727648 -0.1099707105049228 S(ph)SPAAKPGSTPSRPSSAK ddPTM_A459_Selumetinib_30min_R1 1 SSPAAKPGSTPSRPSSAK 18 2 Q15555-5;K7ERD8;Q15555-2;Q15555-4;Q15555-3;Q15555;K7EL66 Q15555-5 MAPRE2 Microtubule-associated protein RP/EB family member 2 1 S(0.297)S(0.297)PAAKPGS(0.2)T(0.2)PS(0.005)RPSSAK 67.312 0.033615 11888000.0 3240.6 3560.1 3540.8 3860.4 3324.9 2909.8 3294.6 3384.8 1932.5 3026.4 True False 3316.0996748900657 3143.2818369544125 3059.9788082221908 3186.25360868285 3024.1633820587745 2880.5300538870133 3046.0856695023217 3295.024108620085 3279.3113557844217 3414.8679196323747 0.9710769941717272 0.9204695206170084 0.8960753037123645 0.9330532493994275 0.8855872183731015 0.8435260518647277 0.8920068773348768 0.9649052865783484 0.9603040096899133 1.0 11.737614063652883 -7.8190894497098435 5.810519714709904 0.9736150945397265 0.9040277446017145 0.48303867814795964 0.03275984279183527 0.19377207625628043 13.214522055371566 0.01963318886994206 0.009380078119201963 1.516737939493829e-08 7.8190894497098435 -0.06958734993801197 S(ph)SPAFGDRR ddPTM_A459_Selumetinib_30min_R1 2 SSPAFGDRR 9 1 P13716;P13716-2 P13716 ALAD Delta-aminolevulinic acid dehydratase 1 S(0.5)S(0.5)PAFGDRR;S(0.5)S(0.5)PAFGDRR 133.75 0.0015644 7525600.0 1091.81 1423.6599999999999 1290.87 1309.1 1354.75 1090.19 1155.42 1248.94 638.4100000000001 1163.88 True False 1117.2470487075602 1256.9772253584217 1115.576944241352 1080.4902598504616 1232.2131017005395 1079.223678413321 1068.2657391660214 1215.814054071132 1083.3351423784386 1313.2753351512458 0.8507332916435916 0.9571315258225417 0.8494615823367112 0.8227446529527831 0.9382747613687797 0.8217802082523923 0.8134362312096515 0.9257876254343195 0.8249109028257766 1.0 10.358953701284543 -10.82138243374428 4.966745223107287 1.0000430096608266 0.8688646744975228 0.37976379315652875 0.050894495079199985 2.3641565205750515e-05 3.33914513763655e-06 0.04806420801056662 0.011653463398175065 1.5087509836716667e-11 10.82138243374428 -0.1311783351633038 S(ph)SPAFGDRR ddPTM_A459_Selumetinib_30min_R2 1 SSPAFGDRR 9 1 P13716;P13716-2 P13716 ALAD Delta-aminolevulinic acid dehydratase 1 S(0.5)S(0.5)PAFGDRR 79.20100000000002 0.025434 5129100.0 9613.2 8865.1 7490.4 9442.5 10964.0 8232.5 7400.4 6026.8 5978.5 6928.3 True False 9078.936828688651 9545.024664210718 7008.475818930883 8156.415210778947 9586.604300596373 9366.452147805683 7744.533263614401 6044.336990209547 7174.367053246992 6728.2619771147665 1.3493732645324117 1.4186464047738885 1.0416472846582407 1.2122618350061043 1.424826252783238 1.392105744345917 1.1510451421119359 0.8983504225561529 1.0663031667984375 1.0 12.716018165303607 -7.5307066804734974 4.876980743742752 0.9894825221732179 1.299540615049762 0.6111516551053946 0.11393785637554704 0.13585692103397762 9.064947087741873 0.057679173939425225 0.03421214448969197 2.9464109477664123e-08 7.5307066804734974 0.31005809287654407 S(ph)SPAFTK ddPTM_A459_Selumetinib_30min_R2 3 SSPAFTK 7 0 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 1 S(0.907)S(0.093)PAFTK;S(0.868)S(0.132)PAFTK;S(0.598)S(0.402)PAFTK 96.034 0.023406 2966900.0 190834.0 163027.0 199710.0 209660.0 207590.0 150041.0 158527.0 182598.0 148787.0 185055.0 True False 180228.2102490295 175530.6466855737 186860.8760278071 181103.94631632665 181510.68832185335 170707.78581341176 165898.81961529123 183129.32994927402 178548.55745612743 179711.9813193676 1.0028725348520002 0.976733133744916 1.0397797334154095 1.0077455325278808 1.010008831850166 0.9498965208671624 0.9231372243371526 1.019015697255229 0.993526175301731 1.0 17.455327070339855 -6.731822792776463 24.976777755859693 0.9749299794733173 1.0075376682540302 0.21615551647317643 0.028711362237185838 329.6875057920218 278037.2308778978 0.010043686216117932 0.01004219446238499 1.8542880829760156e-07 6.731822792776463 0.03260768878071296 S(ph)SPAPHSGPCPSR ddPTM_A459_Selumetinib_30min_R1 4 SSPAPHSGPCPSR 13 0 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.861)S(0.139)PAPHSGPCPSR;S(0.879)S(0.121)PAPHSGPCPSR;S(0.986)S(0.014)PAPHSGPCPSR;S(0.989)S(0.011)PAPHSGPCPSR 187.74 0.00010326 13193500.0 1594.08 1655.5500000000002 2111.76 2171.47 2013.9799999999998 1414.4299999999998 1986.52 1552.8600000000001 539.65 1373.2 True False 1631.2189624602715 1461.7174363556865 1824.994591067357 1792.263528040242 1831.8158645970493 1400.2021183996865 1836.6751970435716 1511.6731083998413 915.7466355234482 1549.4635961007054 1.0527636574136412 0.9433699765739343 1.17782347107737 1.1566993458578525 1.1822258162159447 0.9036689354453746 1.1853619547213934 0.9756105998256651 0.5910088096473939 1.0 10.597553144560763 -8.010306877882575 22.637129015557555 0.7914393208867384 1.0832321798888926 0.4376471201405494 0.13075849495424607 115.87884535204799 254501.59808456578 0.0750088269519948 0.0323731579219006 9.765469368911887e-09 8.010306877882575 0.29179285900215424 S(ph)SPAPHSGPCPSR ddPTM_A459_Selumetinib_30min_R2 2 SSPAPHSGPCPSR 13 0 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.99)S(0.01)PAPHSGPCPSR;S(0.5)S(0.5)PAPHSGPCPSR 208.08 1.0178e-05 8841100.0 11825.3 12272.8 10419.9 12489.5 15062.9 9723.8 12168.0 10534.2 9969.599999999999 11847.0 True False 11168.097166426576 13214.084296728213 9749.494978329323 10788.408554410773 13170.563837965452 11063.165186132152 12733.83611043459 10564.85277796931 11963.798573898335 11504.946327797388 0.9707213617714198 1.1485567963756018 0.8474176845808767 0.9377191554857262 1.1447740356809595 0.9616007646556475 1.1068140387294159 0.9182878804435015 1.039883041000574 1.0 13.489966632750638 -5.179186963922774 24.99997300550395 0.9977864988758778 1.0596377995315496 0.07304355194028334 0.09215787978555708 279.90971517042374 85071.84087523956 0.022907750815128934 0.060608210914155386 6.619314806264341e-06 5.179186963922774 0.06185130065567179 S(ph)SPATSLFVELDEEEVK ddPTM_A459_Selumetinib_30min_R1 4 SSPATSLFVELDEEEVK 17 0 A0A087WTL4;A0A087WX97;Q9BXK5-4;Q9BXK5 A0A087WTL4 BCL2L13 Bcl-2-like protein 13 1 S(0.5)S(0.5)PATSLFVELDEEEVK;S(0.991)S(0.009)PATSLFVELDEEEVK;S(0.5)S(0.5)PATSLFVELDEEEVK;S(0.5)S(0.5)PATSLFVELDEEEVK 331.8 7.988799999999998e-136 15775900.0 6500.76 9473.0 4722.42 4435.07 5257.72 7188.91 7051.16 9303.27 4853.5599999999995 8568.76 True False 6652.215059722996 8363.896756121778 4081.141302396249 3660.568281074774 4782.1601543258585 7116.5960924080255 6519.285324278519 9056.51705832013 8236.13683000312 9668.643812790478 0.6880194563505274 0.8650537674226169 0.42210069803144257 0.37860204098451455 0.49460506012225036 0.736049049918832 0.6742709164292795 0.9366894916885266 0.8518399259995162 1.0 13.239097826714199 -7.583058416520895 1.3865840522043331 0.9468406948875195 0.576567505583977 0.5276616102969258 0.14100132151813716 0.39378898310399535 1.4330120887043276 0.11597628034021701 0.051631190422619544 2.61181001879038e-08 7.583058416520895 -0.3702731893035426 S(ph)SPATSLFVELDEEEVK ddPTM_A459_Selumetinib_30min_R2 2 SSPATSLFVELDEEEVK 17 0 A0A087WTL4;A0A087WX97;Q9BXK5-4;Q9BXK5 A0A087WTL4 BCL2L13 Bcl-2-like protein 13 1 S(0.5)S(0.5)PATSLFVELDEEEVK;S(0.5)S(0.5)PATSLFVELDEEEVK 279.71 1.1575999999999994e-63 10138700.0 52124.0 20649.6 26312.8 37784.5 19643.9 21307.1 59299.4 41630.2 31915.5 20183.4 True False 49227.15674890435 22233.357921070892 24619.863095210472 32638.18591810192 17176.05766330583 24241.95961840395 62056.93959953191 41751.33698974938 38299.49179357773 19600.652799228967 2.511505981619184 1.1343172163095245 1.2560736291486652 1.6651581073557822 0.8763002864874728 1.236793481661874 3.1660649385092445 2.1300993093144203 1.9539906239798461 1.0 14.258614083610698 S(ph)SPCMVR ddPTM_A459_Selumetinib_30min_R2 1 SSPCMVR 7 0 Q13191;A0A2R8Y8D8;A0A2R8Y5E1;A0A2R8YFD4;Q13191-3;Q13191-2 Q13191 CBLB E3 ubiquitin-protein ligase CBL-B 1 S(0.665)S(0.335)PCMVR 83.206 0.039727 4015600.0 21440.0 24077.0 25040.0 23460.0 25602.0 21783.0 22036.0 25133.0 22719.0 22104.0 True False 20248.450631120217 25923.62848024291 23428.953661490614 20264.7075292427 22385.647875216015 24783.410523613875 23060.717663505628 25206.13286900787 27263.43482189819 21465.800086910902 0.9432888850701175 1.2076711967540514 1.0914549453843454 0.9440462245616186 1.0428517821176395 1.1545533091368878 1.0743004020412568 1.1742461388326118 1.2700870552932468 1.0 14.389752326381625 -6.759925424873172 24.996732537748404 1.1417567111977234 1.0517284052012845 0.17376003705897092 0.09574081902540549 75.46219389343572 1245959.6603384868 0.03281378002419325 0.031144241764621213 1.7380992618405855e-07 6.759925424873172 -0.09002830599643885 S(ph)SPEIQEPIKPLEK ddPTM_A459_Selumetinib_30min_R2 1 SSPEIQEPIKPLEK 14 1 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 S(0.5)S(0.5)PEIQEPIKPLEK 79.92 0.019272 2711300.0 18801.0 14144.0 14444.0 17105.0 17473.0 12417.0 17882.0 15514.0 13119.0 12656.0 True False 17756.115686366174 15228.799319871903 13514.688765438124 14775.269492229165 15277.885529398076 14127.329039696717 18713.54843251077 15559.143171519036 15743.166575486703 12290.588395762947 1.4446920777598746 1.2390618601402252 1.0995965636679506 1.202161281173714 1.24305566482602 1.1494428569886017 1.522591744994249 1.265939649958735 1.2809123589977187 1.0 13.585266364041924 S(ph)SPELEDTATSSK ddPTM_A459_Selumetinib_30min_R1 1 SSPELEDTATSSK 13 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.889)S(0.111)PELEDTATSSK 127.78 0.0018928 7491100.0 957.82 3423.0 1116.7 1368.1 1236.9 1168.2 1520.0 1105.1 511.69 1256.9 True False 980.1353424067148 3022.2335686904744 965.0582735940244 1129.187017417627 1125.0226133924311 1156.4489686407348 1405.3451762409784 1075.7891581292997 868.3005576410507 1418.2353582427747 0.6910949841365712 2.130981681654792 0.6804641190089585 0.7961915565387644 0.7932552286570822 0.8154140015755924 0.9909111122305062 0.7585406412813078 0.6122401000613146 1.0 10.469881254470616 -5.3419925120483605 24.999998540405578 0.8034050405500657 1.4111652834017432 0.33473831548222965 0.34123599875898214 88.96661744565259 27610.214384898 0.08112184817667782 0.16886861897955027 4.549959049606635e-06 5.3419925120483605 0.6077602428516775 S(ph)SPELEDTATSSK ddPTM_A459_Selumetinib_30min_R2 2 SSPELEDTATSSK 13 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.899)S(0.101)PELEDTATSSK;S(0.884)S(0.115)PELEDTATSSK 149.82 0.00050901 15472000.0 89017.0 100167.0 104370.0 63739.0 55979.0 58474.0 84234.0 73819.0 60658.0 95826.0 True False 84069.79150328493 107849.48681233094 97654.94782946401 55057.63824409208 48946.417561390444 66528.26272587795 88151.0479065045 74033.80106860667 72791.29492612786 93059.25439415121 0.903400656394779 1.158933493659168 1.0493845933457386 0.5916406552205565 0.5259704462500694 0.7149021680756048 0.9472571909199049 0.7955554936539413 0.7822037195550838 1.0 16.505862007584113 -5.740060361129642 24.606284189054772 0.7523447835242327 1.0494092452988013 0.41798855747971797 0.14624291063922787 189.55898458164285 218171.6690116548 0.04183328225189902 0.07236397031455062 1.8194479620817599e-06 5.740060361129642 0.2970644617745686 S(ph)SPELLPSGVTDENEVTTAVTEK ddPTM_A459_Selumetinib_30min_R1 3 SSPELLPSGVTDENEVTTAVTEK 23 0 B1AUU8;P42566;P42566-2 B1AUU8 EPS15 Epidermal growth factor receptor substrate 15 1 S(0.5)S(0.5)PELLPSGVTDENEVTTAVTEK;S(0.5)S(0.5)PELLPSGVTDENEVTTAVTEK;S(0.5)S(0.5)PELLPSGVTDENEVTTAVTEK 242.5 1.6662e-37 29328700.0 17645.4 19179.1 15424.900000000001 15265.300000000001 17538.8 14715.0 19455.9 18610.3 9905.6 15736.5 True False 18056.5034880285 16933.602055878306 13330.283302910771 12599.501920170538 15952.418636726632 14566.980460151 17988.32579896505 18116.694389226042 16809.079723600604 17756.433061490494 1.016899251414902 0.9536601184053843 0.7507297922250502 0.7095739260547705 0.8984022062023064 0.8203776293192205 1.0130596464206245 1.0202890595474872 0.9466473173632786 1.0 14.116054179630897 -7.265333525522651 24.963429828179088 0.9966897678708926 0.8527861264033973 0.37484184662549025 0.08631636873208834 387.8590987226738 2486356.0562930657 0.03861517593386449 0.02715153622297167 5.428332912061824e-08 7.265333525522651 -0.14390364146749524 S(ph)SPELTR ddPTM_A459_Selumetinib_30min_R1 1 SSPELTR 7 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.675)S(0.325)PELTR 129.42 0.0046489 59857000.0 2798.0 2923.3 2271.5 2739.4 2470.3 2183.3 2309.7 2253.8 1361.9 2301.4 True False 2863.1879560397465 2581.0386769946995 1963.0427764563678 2261.0152149066935 2246.8618011668873 2161.3379842777904 2135.477469449863 2194.021902625842 2311.044830759536 2596.807107534348 1.1025801445677363 0.9939277620991186 0.7559447795567168 0.870690475371316 0.8652401615229206 0.8323059414027741 0.8223473600538184 0.8448921355229392 0.8899562944256799 1.0 11.34252313836306 -5.03133748034859 4.553204789463742 0.8530650909497137 1.0846679914276784 0.637441699469607 0.05911340846753837 0.09885989360627717 4.9686656800959 0.014129238055056252 0.04777977518712353 9.303846138000671e-06 5.03133748034859 0.23160290047796472 S(ph)SPELTR ddPTM_A459_Selumetinib_30min_R2 3 SSPELTR 7 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.704)S(0.296)PELTR;S(0.5)S(0.5)PELTR;S(0.704)S(0.296)PELTR 154.12 0.0017634 478663500.0 138153.0 110597.0 141196.0 160395.0 157012.0 122114.0 133745.3 154121.0 128053.0 122335.0 True False 130475.00933027753 119079.4342745951 132111.60308258125 138548.92430319174 137286.7488549105 138934.09505947694 139964.72146128424 154569.466593895 153667.17809976384 118802.87068549775 1.0982479512273655 1.0023279200872972 1.1120236600369295 1.1662085562727433 1.1555844405338016 1.1694506560137912 1.178125752801104 1.3010583473448278 1.2934635098722573 1.0 16.858210171465174 -5.8426362017684195 0.9387796656618766 1.2083434799817165 1.0399450669706434 0.2641556666659831 0.08282942779867684 0.7849726092476719 1.3296807656451726 0.034512428802647314 0.09591719716665481 1.4366924127361082e-06 5.8426362017684195 -0.16839841301107317 S(ph)SPEQPIGQGR ddPTM_A459_Selumetinib_30min_R1 2 SSPEQPIGQGR 11 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 1 S(0.856)S(0.144)PEQPIGQGR;S(0.984)S(0.016)PEQPIGQGR 147.58 0.00066406 14847300.0 3860.2 5131.3 4847.200000000001 6054.6 4499.3 4336.1 4727.3 4474.8 2454.91 3576.1 True False 3950.1351493583343 4530.525010523349 4188.976863763726 4997.277768918039 4092.339109415931 4292.482770863798 4370.715955028935 4356.1137678010955 4165.802970467651 4035.1272691638046 0.9789369419757897 1.1227712803869518 1.0381275693026168 1.2384436563146173 1.0141784475273767 1.0637787818160502 1.0831668156862557 1.079548048233881 1.0323845302978327 1.0 11.97839846193116 -8.437416660435462 2.5100663810709363 1.000348086527404 1.080952849469691 0.1278432671654962 0.06601231458079801 0.5258588683683026 6.935198492973899 0.060633980489975495 0.0165869320539316 3.6524420959351974e-09 8.437416660435462 0.08060476294228702 S(ph)SPEQPIGQGR ddPTM_A459_Selumetinib_30min_R2 3 SSPEQPIGQGR 11 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 1 S(0.997)S(0.003)PEQPIGQGR;S(0.999)S(0.001)PEQPIGQGR;S(0.989)S(0.011)PEQPIGQGR 173.72 0.00017348 92554000.0 156134.0 143480.0 171583.0 199386.0 200167.0 151993.0 158352.0 158737.0 137058.0 170851.0 True False 147456.6973339235 154484.4546390849 160543.5365854448 172229.28283996505 175020.23194431537 172928.65609492018 165715.6817685351 159198.89838967513 164473.42972048593 165918.08770579105 0.8887319000168106 0.9310886882509128 0.9676072018749606 1.0380380175630104 1.0548592643778802 1.0422531894265825 0.998780085160969 0.9595029727679208 0.991292944577165 1.0 17.340111645968726 -5.288037855051469 2.0830535249060227 1.0124211393873592 0.8964565029527193 0.6867267461900128 0.027705990997548103 0.2310634568611376 1.8406019619260445 0.0090842785175377 0.033196726280552376 5.151837369035152e-06 5.288037855051469 -0.11596463643463994 S(ph)SPEQPRPSTSK ddPTM_A459_Selumetinib_30min_R2 2 SSPEQPRPSTSK 12 1 P29590-2;P29590;P29590-9;P29590-8;P29590-5;P29590-3;P29590-4;P29590-12;P29590-13;P29590-11;H3BVD2;H3BT57;H3BUJ5;H3BRN3 P29590-2 PML Protein PML 1 S(0.865)S(0.135)PEQPRPSTSK;S(0.914)S(0.086)PEQPRPSTSK 174.46 0.0006735 55105000.0 166185.0 163472.0 174708.0 189801.0 187092.0 128378.0 130554.0 150381.0 119198.0 153218.0 True False 156949.10299126443 176009.77675467337 163467.477487688 163949.7763750122 163587.8303362986 146060.9042005464 136625.0196878432 150818.58381308522 143040.9306703913 148794.19823182726 1.054806604399531 1.1829075249321426 1.0986145927074333 1.101855975053355 1.0994234471523028 0.9816303722607365 0.9182146972893123 1.0136052722842317 0.9613340598638656 1.0 17.18295874856183 -6.755490929169569 4.535046243559502 0.9709470865182337 1.1123369719222114 0.7569588735391591 0.037591441779502535 0.09099210328694005 4.592766383708855 0.012734898722083042 0.011980616634951098 1.755937568958469e-07 6.755490929169569 0.14138988540397768 S(ph)SPETSMLLDQVHPPINEDSLR ddPTM_A459_Selumetinib_30min_R1 1 SSPETSMLLDQVHPPINEDSLR 22 0 Q4AC94;Q4AC94-2;Q4AC94-4;Q4AC94-1;Q4AC94-3;F5H0U2 Q4AC94 C2CD3 C2 domain-containing protein 3 1 S(0.398)S(0.398)PET(0.114)S(0.091)MLLDQVHPPINEDSLR 108.13 8.196600000000001e-05 0.0 318.23 371.98 437.94 645.34 467.72 346.6 373.03 249.55 242.69 354.44 True False 325.64413983221147 328.4284086711898 378.47015343222597 532.6434835321188 425.4148085826727 343.1135186876205 344.89204677182397 242.93112334735935 411.8272046237105 399.9358265379656 0.8142409812372693 0.8212027702399708 0.946327206313181 1.3318223779623188 1.0637076759670803 0.8579214361908359 0.8623684698552097 0.6074252598230233 1.0297332154227898 1.0 8.643624714367421 -6.82078282197643 8.217349063295154 0.8456661853231672 1.0015899592695074 0.10476899095982783 0.17276085347732825 0.5538039038162302 68.36985349251981 0.06531175450803324 0.05774402373191827 1.510835490120121e-07 6.82078282197643 0.15592377394634027 S(ph)SPGAGPSDHHSASR ddPTM_A459_Selumetinib_30min_R1 4 SSPGAGPSDHHSASR 15 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 S(0.5)S(0.5)PGAGPSDHHSASR;S(0.5)S(0.5)PGAGPSDHHSASR;S(0.5)S(0.5)PGAGPSDHHSASR;S(0.5)S(0.5)PGAGPSDHHSASR 113.81 0.0017669 3443400.0 968.3 1344.78 1242.1260000000002 1459.5900000000001 1322.69 1373.53 1709.38 1167.23 443.922 998.47 True False 990.8595060161842 1187.3325324287391 1073.4521117097258 1204.7000063976272 1203.052923039887 1359.7135352654582 1580.4400903702663 1136.2712687026176 753.303211219939 1126.6333504214044 0.8794871070038576 1.0538766067812841 0.9527963212772046 1.0692919803474865 1.0678300288109692 1.2068820213398377 1.402798958311611 1.0085546183038236 0.6686320895242224 1.0 10.137802368413633 -3.7101067706702753 0.8474264571687614 1.0756916271589652 1.9129246267136038e-08 0.06354427865320322 0.17695069204406436 35.2040399784988 4.942787069656501 0.0659385752242336 53.99199542156615 0.00019493652922041163 3.7101067706702753 -1.075691608029719 S(ph)SPGAGPSDHHSASR ddPTM_A459_Selumetinib_30min_R2 4 SSPGAGPSDHHSASR 15 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 S(0.5)S(0.5)PGAGPSDHHSASR;S(0.866)S(0.134)PGAGPSDHHSASR;S(0.871)S(0.129)PGAGPSDHHSASR;S(0.5)S(0.5)PGAGPSDHHSASR 145.82 0.00023511 9371480.0 609.71 703.89 1708.0 3585.6800000000003 4779.53 1348.0 749.75 1640.62 3532.7999999999997 3310.0299999999997 True False 575.824759062514 757.8760996369222 1598.109139529792 3097.3041983569906 4179.08271185967 1533.6747640743474 784.6148606014406 1645.3939325807382 4239.458714679429 3214.4608334092295 0.17913572101352973 0.23577083029290646 0.49716242391880416 0.9635532547683949 1.300088235148092 0.4771172658674908 0.2440891027343098 0.5118724469993456 1.3188708571642778 1.0 11.650361056990326 -5.4813718762300825 3.378720349297698 0.7897425070183182 0.21444428066529062 0.36177147372987617 0.33094052143835423 0.3042416860844155 6.994465335353793 0.09880025414786756 0.21491749418426886 3.3008677438890403e-06 5.4813718762300825 -0.5752982263530275 S(ph)SPGAVAGLSNAPGTPR ddPTM_A459_Selumetinib_30min_R1 1 SSPGAVAGLSNAPGTPR 17 0 Q9BWG4-2;Q9BWG4;V9GYB2;U3KPY3 Q9BWG4-2;U3KPY3 SSBP4 Single-stranded DNA-binding protein 4 1 S(0.866)S(0.134)PGAVAGLSNAPGTPR 300.29 3.7656999999999995e-89 27061000.0 1391.4 1679.8 1552.1 1427.6 1237.6 1222.7 1759.4 1522.2 743.78 1269.9 True False 1423.8169128068978 1483.1282350821657 1341.3333450750292 1178.2964593709555 1125.6592985160269 1210.4007481227757 1626.6870414989332 1481.826311197557 1262.1403364581302 1432.904034873498 0.9936582479737365 1.0350506377163644 0.9360943318115836 0.8223135888335885 0.7855789858358548 0.8447186403726152 1.1352379516766056 1.0341420465944728 0.8808268423708895 1.0 10.484726276643084 -7.239734230437078 24.973386592085394 1.0153969087273156 0.9014218584907316 0.2564764886359293 0.09138860211817439 1234.7821737366112 1420710.676625541 0.03920665169544896 0.03033953817037986 5.7579218962495435e-08 7.239734230437078 -0.11397505023658394 S(ph)SPGAVAGLSNAPGTPR ddPTM_A459_Selumetinib_30min_R2 3 SSPGAVAGLSNAPGTPR 17 0 Q9BWG4-2;Q9BWG4;V9GYB2;U3KPY3 Q9BWG4-2;U3KPY3 SSBP4 Single-stranded DNA-binding protein 4 1 S(0.981)S(0.019)PGAVAGLSNAPGTPR;S(0.889)S(0.111)PGAVAGLSNAPGTPR;S(0.98)S(0.02)PGAVAGLSNAPGTPR 222.09 4.2963e-12 60765000.0 87641.0 67670.0 76924.0 76262.0 89750.0 55304.0 59986.0 62831.0 58412.0 68650.0 True False 82770.26407472052 72860.07140665539 71974.79358851841 65874.98404071208 78474.80262481995 62921.624000272765 62775.467860003984 63013.82780776799 70096.03216764463 66667.89612587914 1.2415310649437272 1.0928809163121704 1.0796019939285175 0.9881065380603894 1.1771003314196022 0.9438069544217679 0.9416146527479184 0.945189986028482 1.0514210923244474 1.0 16.024704579490958 -1.5228787452824892 0.43968036519580106 0.9836478897176403 6.127401658655138 0.5467793973446962 0.06587412330859202 66.08234399992803 0.8141454580851096 0.04326377886334512 303.1045524640759 0.029999999999851368 1.5228787452824892 5.143753768937498 S(ph)SPGGQDEGGFMAQGK ddPTM_A459_Selumetinib_30min_R1 2 SSPGGQDEGGFMAQGK 16 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30 A0A1B0GTU4 PXN Paxillin 1 S(0.5)S(0.5)PGGQDEGGFMAQGK;S(0.5)S(0.5)PGGQDEGGFMAQGK 149.94 0.00092754 14763900.0 5827.6 6974.4 5494.0 5050.6 5391.4 5096.200000000001 6125.700000000001 5699.7 3460.9 5585.1 True False 5963.371741464341 6157.8340056894085 4747.94497638181 4168.60752150389 4903.748821928978 5044.93685497938 5663.633517170634 5548.5254407651555 5872.894525865096 6302.001988480957 0.9462662424360421 0.9771234628210108 0.7534026465019033 0.6614735331920606 0.7781255592892925 0.8005292388356446 0.8987038606974168 0.8804385417375248 0.9319093419202024 1.0 12.621594494233529 -8.130469467103806 1.0812424314180324 0.9911721079725291 0.8180164031189809 0.3006443531095986 0.08722316754647122 0.6956463732203401 1.558747871893752 0.09276760148657948 0.03206583649243007 7.40509326826687e-09 8.130469467103806 -0.17315570485354814 S(ph)SPGGQDEGGFMAQGK ddPTM_A459_Selumetinib_30min_R2 5 SSPGGQDEGGFMAQGK 16 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30 A0A1B0GTU4 PXN Paxillin 1 S(0.611)S(0.389)PGGQDEGGFMAQGK;S(0.84)S(0.16)PGGQDEGGFMAQGK;S(0.5)S(0.5)PGGQDEGGFMAQGK;S(0.861)S(0.139)PGGQDEGGFMAQGK;S(0.999)S(0.001)PGGQDEGGFMAQGK 325.33 5.336099999999997e-118 286155000.0 260486.0 261209.0 277418.0 281192.0 301333.0 226241.0 255669.0 252366.0 201510.0 251659.0 True False 246009.23092807713 281242.8903806854 259569.22790987985 242893.1645167442 263476.8545888008 257403.64413868304 267558.11509851256 253100.34327855962 241817.63065983122 244392.9507813929 1.006613448307394 1.150781515921277 1.0620978513494932 0.9938632179862248 1.0780869650552167 1.0532367783755272 1.0947865486424797 1.0356286565112731 0.9894623796908723 1.0 17.898843147402808 -8.067735064933972 4.079545418392267 0.9965372272131034 1.06389914406504 0.2974841780241878 0.04139190131852676 0.29008864851846705 9.165994081379184 0.02995106020359443 0.010769888239521968 8.555884930992368e-09 8.067735064933972 0.0673619168519366 S(ph)SPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR ddPTM_A459_Selumetinib_30min_R1 1 SSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR 34 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.446)S(0.446)PGLY(0.02)T(0.024)S(0.026)PGQDS(0.032)LQPT(0.005)AVSPPYGGDISPVSPSR 52.17 0.0031733 6130200.0 423.5 532.39 557.89 691.4 500.38 665.52 561.54 537.43 400.75 516.43 True False 433.36672601244885 470.0575312986039 482.13160227041317 570.6599691854012 455.1207173492643 658.8254730438125 519.1825857015522 523.175610581332 680.0434803780627 582.7188209541855 0.7436978357809401 0.8066626894406775 0.8273829245483034 0.9793058824682576 0.7810297196236378 1.1306061334435784 0.8909658775932541 0.8978182817652033 1.1670182186058635 1.0 9.186656098123876 -4.294058113870735 0.3183359246802978 1.0340259838723616 0.4074032847146234 0.4462196530019439 0.10213870751778016 9.516448726467676 0.6152563901674849 0.10298609530924566 2.445293131071274 5.080914492111959e-05 4.294058113870735 -0.6266226991577382 S(ph)SPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR ddPTM_A459_Selumetinib_30min_R2 1 SSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR 34 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.471)S(0.471)PGLY(0.011)T(0.004)S(0.016)PGQDS(0.027)LQPTAVSPPYGGDISPVSPSR 75.794 5.6728e-06 2621200.0 10765.0 11085.0 12883.0 16063.0 15257.0 9721.3 10051.0 10366.0 8389.9 9869.1 True False 10166.724395709381 11935.183856107178 12054.12180594983 13875.191689779434 13340.279260689425 11060.320833824895 10518.391415678665 10396.163343816317 10068.114433392475 9584.153439998741 1.060784811027683 1.2453039207716134 1.2577137752869088 1.4477221985900568 1.3919100256695367 1.154021677873549 1.0974773600536227 1.0847242178353191 1.0504959563120055 1.0 13.226435290175392 -6.984154980582693 4.41876703389387 1.0706386576839475 1.286940765437947 0.5283487706185807 0.09876614002588642 0.18210479733867252 8.71829606919116 0.04034682156449511 0.03384257430060117 1.0371582336538065e-07 6.984154980582693 0.2163021077539995 S(ph)SPGPDTLVVLEFNPASK ddPTM_A459_Selumetinib_30min_R1 2 SSPGPDTLVVLEFNPASK 18 0 O60303 O60303 KIAA0556 Uncharacterized protein KIAA0556 1 S(0.5)S(0.5)PGPDTLVVLEFNPASK;S(0.749)S(0.251)PGPDTLVVLEFNPASK 260.25 1.3138999999999994e-42 43501000.0 7040.6 7474.1 5552.4 5288.6 6318.200000000001 5805.6 7031.9 7055.0 3820.0 6301.7 True False 7204.6322813772085 6599.028897385181 4798.414577150046 4365.045289317205 5746.71992556881 5747.200935063042 6501.478121584831 6867.878482130313 6482.260998238805 7110.584578756053 1.0132264375143132 0.9280571553991184 0.6748270165417954 0.613879947699158 0.8081923310128404 0.8082599779817927 0.9143380617409405 0.9658669278260383 0.9116354536595402 1.0 12.79575245691236 -7.334343122213259 2.745265157714212 0.9536359850024497 0.7965594661749178 0.29103374504132196 0.1080309001335221 0.409672154273492 6.050383602982321 0.05749735781139007 0.036677425724069 4.630809097175125e-08 7.334343122213259 -0.15707651882753193 S(ph)SPGPDTLVVLEFNPASK ddPTM_A459_Selumetinib_30min_R2 2 SSPGPDTLVVLEFNPASK 18 0 O60303 O60303 KIAA0556 Uncharacterized protein KIAA0556 1 S(0.5)S(0.5)PGPDTLVVLEFNPASK;S(0.497)S(0.497)PGPDT(0.005)LVVLEFNPASK 93.753 0.0044947 5035400.0 50606.0 44890.0 56992.0 59725.0 61131.0 45147.0 48488.0 54675.0 47669.0 54148.0 True False 47793.5211118689 48332.918655900015 53325.1967681978 51590.351968628296 53451.177261926074 51365.58944633867 50742.788077149235 54834.09519806648 57204.13198314471 52584.606546600226 0.9088880615568457 0.9191457696477697 1.0140837836438172 0.9810922883469552 1.0164795511887665 0.9768179857125817 0.9649741893985879 1.0427784631130173 1.0878493867297587 1.0 15.682352910832735 -2.253091212192379 0.3832337733330556 1.0259297260605114 5.844773523961565e-10 0.5442282953467124 0.034559677114262465 32.251036329076086 0.7521872332018954 0.028252294796375026 22.59058587369354 0.00558352915001295 2.253091212192379 -1.025929725476034 S(ph)SPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR ddPTM_A459_Selumetinib_30min_R1 2 SSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR 36 1 P40222 P40222 TXLNA Alpha-taxilin 1 S(0.5)S(0.5)PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR;S(0.5)S(0.5)PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR 141.44 4.5583e-35 70679000.0 166.14 449.24 511.71999999999997 436.98 430.26 358.83 389.72 392.36 231.78000000000003 351.37 True False 170.01073874783532 396.64277195399023 442.23123467675657 360.66964613051294 391.34305896857256 355.2204959915723 360.323106634628 381.95333823510293 393.313731458584 396.47176213363304 0.42880919900301057 1.000431329130319 1.1154167255112106 0.9096981943671116 0.9870641401106094 0.8959540878269239 0.9088241359120529 0.9633809383538477 0.9920346643149214 1.0 8.631074306446727 -4.759608020658403 24.99951128354077 0.9718359923638847 0.42880851796213915 0.8801212198632331 0.06043789880029624 15.99777310000399 218321.61942771805 0.015916577079609452 0.09993020993302722 1.7393700163660232e-05 4.759608020658403 -0.5430274744017456 S(ph)SPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR ddPTM_A459_Selumetinib_30min_R2 2 SSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR 36 1 P40222 P40222 TXLNA Alpha-taxilin 1 S(0.76)S(0.24)PGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPR;S(0.5)S(0.5)PGQPEAGPEGAQERPS(0.001)QAAPAVEAEGPGSSQAPR 114.73 5.5481e-23 120962000.0 16573.2 17326.9 22730.0 20451.2 25468.2 14261.0 15604.4 14436.8 8086.2 21447.0 True False 15652.127891776185 18655.81751523534 21267.576546552795 17665.711279712203 22268.657027403187 16225.323301531364 16330.035519532008 14478.80869785909 9703.665947305486 20827.769384001884 0.7515028423446447 0.8957184598733433 1.0211163833458197 0.8481806646698083 1.069181083045219 0.7790235719622608 0.7840511011263332 0.6951684758417037 0.46590039328738747 1.0 14.346220717201716 -7.162008417896698 2.2845502115191323 0.7007523688049687 0.9166089720622159 0.23150756306453923 0.14900059447693326 0.39531507454725057 4.037949370091718 0.06620095212222794 0.04666982484577783 6.886389483788936e-08 7.162008417896698 0.2158566032572472 S(ph)SPGQTPEEGAQALAEFAALHGPALR ddPTM_A459_Selumetinib_30min_R1 4 SSPGQTPEEGAQALAEFAALHGPALR 26 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 1 S(0.491)S(0.491)PGQT(0.019)PEEGAQALAEFAALHGPALR;S(0.496)S(0.496)PGQT(0.007)PEEGAQALAEFAALHGPALR;S(0.49)S(0.49)PGQT(0.019)PEEGAQALAEFAALHGPALR;S(0.486)S(0.486)PGQT(0.028)PEEGAQALAEFAALHGPALR 215.88 3.073e-35 303151000.0 5509.57 7445.25 8687.490000000002 8001.42 7776.579999999999 7198.5 7626.379999999999 7230.099999999999 3938.17 5663.969999999999 True False 5637.932261242995 6573.556668797176 7507.77657496673 6604.122202255504 7073.189712066711 7126.089625715052 7051.116016566235 7038.334261325353 6682.786857443481 6390.995721239816 0.8821680544247446 1.0285653371587524 1.174742857363432 1.0333479304809083 1.106742989759748 1.1150202466936767 1.1032891155180369 1.101289152476534 1.04565660014979 1.0 12.641825006160404 -4.834531982714389 3.4879378894742334 1.0899580429837332 0.8684244721979861 0.626823367669983 0.046953247231807924 0.15008540215111024 3.037615357991289 0.011051059643780288 0.08079216112486783 1.4637537384798562e-05 4.834531982714389 -0.2215335707857471 S(ph)SPGQTPEEGAQALAEFAALHGPALR ddPTM_A459_Selumetinib_30min_R2 5 SSPGQTPEEGAQALAEFAALHGPALR 26 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 1 S(0.486)S(0.486)PGQT(0.027)PEEGAQALAEFAALHGPALR;S(0.411)S(0.411)PGQT(0.177)PEEGAQALAEFAALHGPALR;S(0.473)S(0.473)PGQT(0.054)PEEGAQALAEFAALHGPALR;S(0.494)S(0.494)PGQT(0.012)PEEGAQALAEFAALHGPALR;S(0.499)S(0.499)PGQT(0.001)PEEGAQALAEFAALHGPALR 166.68 3.4654e-17 163861700.0 78924.7 73670.2 80013.0 93286.2 83625.1 69021.6 69784.0 72097.9 57669.6 75018.7 True False 74538.38113460693 79320.46745297119 74865.05069156739 80580.45863232894 73119.36732012064 78528.69888429812 73029.09427437269 72307.69295255012 69205.13142325537 72852.7152090092 1.0231379972697199 1.0887784652281864 1.027621969569493 1.1060735128560328 1.0036601533703504 1.0779103930307188 1.0024210362627868 0.9925188477204254 0.9499320817997082 1.0 16.152695121853988 -7.4751720132947845 2.923867049387702 0.97867731977202 1.0549602513447174 0.5250112538345884 0.03209177079956618 0.19837724600600998 3.370438793940449 0.014930678823415009 0.008716765714921767 3.348327939088027e-08 7.4751720132947845 0.07628293157269739 S(ph)SPGSVAASPSGGGGR ddPTM_A459_Selumetinib_30min_R2 2 SSPGSVAASPSGGGGR 16 0 Q9BXB5;Q9BXB5-2 Q9BXB5 OSBPL10 Oxysterol-binding protein-related protein 10 1 S(0.972)S(0.028)PGSVAASPSGGGGR;S(0.974)S(0.026)PGSVAASPSGGGGR 144.4 0.0003893 10157700.0 30929.5 25996.5 33886.4 34280.8 31731.0 25476.2 30089.2 31238.3 22255.6 32943.3 True False 29210.562210598517 27990.34795807762 31706.185916722672 29611.69590232155 27744.66810126083 28985.315300082246 31488.4074206187 31329.198281221055 26707.341873420366 31992.141332027295 0.9130543000369862 0.874913237834959 0.9910616981734088 0.925592807152215 0.8672338563810256 0.9060136050057106 0.9842544484227973 0.9792779406690553 0.8348094488656087 1.0 14.965429939233626 -7.218594499817581 24.917258345749772 0.9478586753834722 0.9132913631068472 0.10381004800352656 0.052590319136439544 1199.2915640978595 697471.4434603165 0.02019496711189796 0.015642854843831912 6.045127987526578e-08 7.218594499817581 -0.03456731227662502 S(ph)SPHGSLGSVVNSLSGLK ddPTM_A459_Selumetinib_30min_R1 1 SSPHGSLGSVVNSLSGLK 18 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.491)S(0.491)PHGS(0.018)LGS(0.001)VVNSLSGLK 64.538 0.023229 3538400.0 2885.1 3100.1 2886.3 3019.5 3937.0 3174.7 3998.3 2639.1 1242.0 2378.7 True False 2952.317216572647 2737.1388508026107 2494.3563133110333 2492.2010080348837 3580.899045133803 3142.765400396969 3696.705011950204 2569.1024949950543 2107.583287909057 2684.029315500107 1.0999571426150951 1.0197872411436788 0.9293327382477816 0.9285297271689894 1.3341504969615376 1.1709132170232603 1.3772968091674544 0.957181235003151 0.7852310985345395 1.0 11.390184713687388 -7.985981725772127 24.976848731834735 0.8854789890509427 1.1177533616085875 0.29797651889339516 0.14879622790833014 282.51163833799893 503360.67290841177 0.08820435813889153 0.04234231465092537 1.0328048631736527e-08 7.985981725772127 0.23227437255764483 S(ph)SPKEELHPAAPSQLAPSFSSSSSSSSGPR ddPTM_A459_Selumetinib_30min_R1 1 SSPKEELHPAAPSQLAPSFSSSSSSSSGPR 30 1 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 S(0.5)S(0.465)PKEELHPAAPS(0.03)QLAPS(0.001)FSSSSSSSS(0.001)GPR 42.505 0.031471 8835900.0 984.37 1267.1 1618.7 1867.9 1222.8 1279.9 1439.2 1540.2 992.85 1597.3 True False 1007.3039057494082 1118.7473429411916 1398.8894308826418 1541.7063298255869 1112.1979559028748 1267.025368056219 1330.639985293432 1499.3488927253168 1684.7939351050777 1802.3290140195584 0.5588901348832623 0.6207231500125266 0.7761565285812246 0.8553967215937283 0.6170893034798615 0.7029933814528658 0.7382891663746984 0.8318952206076211 0.9347871126746422 1.0 10.815646682920471 -8.072923905207551 1.3102929205799527 0.9985638906744286 0.6923369798512422 0.6651564773986025 0.07903221987945927 0.29178163391124134 0.9110027213092686 0.07867104658339488 0.026120645418441283 8.454269634448065e-09 8.072923905207551 -0.3062269108231864 S(ph)SPKEELHPAAPSQLAPSFSSSSSSSSGPR ddPTM_A459_Selumetinib_30min_R2 3 SSPKEELHPAAPSQLAPSFSSSSSSSSGPR 30 1 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 S(0.499)S(0.499)PKEELHPAAPS(0.002)QLAPSFSSSSSSSSGPR;S(0.5)S(0.5)PKEELHPAAPSQLAPSFSSSSSSSSGPR;S(0.8)S(0.2)PKEELHPAAPSQLAPSFSSSSSSSSGPR 95.889 4.0155000000000005e-08 31808800.0 72238.8 62920.9 77420.9 83741.7 71154.7 54388.0 63034.8 64313.4 54442.7 67134.1 True False 68224.05669082871 67746.73070741858 72439.72358350233 72335.9359975101 62215.610454911024 61879.453314892846 65966.04310108663 64500.54134634348 65332.76125613612 65195.76409766039 1.046449223121798 1.0391277967988375 1.1111108917289598 1.1095189541632497 0.9542891523092631 0.9491330329712855 1.0118148627305357 0.9893363815741849 1.0021013199303948 1.0 15.992490612198738 -6.262917113761973 24.997256276616735 0.983515425318138 1.0763470929456271 0.715936737424357 0.028418828948466892 78.45659467806085 1327156.222710943 0.009492866851052847 0.01133535878496533 5.45862030346986e-07 6.262917113761973 0.09283166762748918 S(ph)SPKSEIEVISEPPEEK ddPTM_A459_Selumetinib_30min_R1 2 SSPKSEIEVISEPPEEK 17 1 B7ZM87;O75044;A0A075B7E9;A0A075B7E6;Q5VZB4 B7ZM87 SRGAP2 SLIT-ROBO Rho GTPase-activating protein 2 1 S(0.498)S(0.498)PKS(0.005)EIEVISEPPEEK;S(0.499)S(0.499)PKS(0.001)EIEVISEPPEEK 114.76 0.00092785 35588000.0 9633.1 11689.5 14703.8 14670.2 9252.0 11587.6 11051.2 10399.6 6386.7 9425.5 True False 9857.532487250346 10320.88790569888 12707.104722192003 12108.324963760017 8415.158233573273 11471.039264698995 10217.599086627832 10123.768825338402 10837.763433887896 10635.354737144775 0.9268644752226434 0.9704319377004328 1.1947983904863546 1.1384975172920921 0.7912437752718018 1.0785760840337115 0.960720101882648 0.9518976165393317 1.0190316826984804 1.0 13.376580534050145 S(ph)SPLKITLFLEEDK ddPTM_A459_Selumetinib_30min_R1 1 SSPLKITLFLEEDK 14 1 Q9NQW6 Q9NQW6 ANLN Actin-binding protein anillin 1 S(0.5)S(0.5)PLKITLFLEEDK 90.259 0.01016 28920000.0 4867.4 2746.6 7339.7 7188.9 4882.3 4634.9 3543.6 3934.7 3106.3 3177.9 True False 4980.800949688295 2425.0267951403016 6343.0090540862 5933.493567366111 4440.696827040078 4588.277114152489 3276.303399031271 3830.338974293145 5271.164224824399 3585.8144203673432 1.3890292039090089 0.6762834075757533 1.768917269688597 1.6547129527016247 1.2384067624406387 1.2795634620941845 0.9136845957286421 1.0681921943692645 1.4700047484008953 1.0 11.80808510980542 -6.935569250921614 3.088346543438612 1.1174740677537058 1.3499309270803501 0.11241462852911133 0.303743470273067 0.6421613119020587 12.437946165323254 0.12303346080995614 0.104007300321005 1.159927243880223e-07 6.935569250921614 0.23245685932664428 S(ph)SPLLR ddPTM_A459_Selumetinib_30min_R2 1 SSPLLR 6 0 P56524-2;P56524;Q9UKV0-10;Q9UKV0-3;Q9UKV0-4;Q9UKV0-2;Q9UKV0;Q9UQL6-2;Q9UKV0-5;Q9UKV0-7;Q9UQL6;Q9UQL6-3 P56524-2 HDAC4;HDAC9;HDAC5 Histone deacetylase 4;Histone deacetylase 9;Histone deacetylase 5 1 S(0.996)S(0.004)PLLR 93.195 0.042231 3164700.0 10784.0 11087.0 12065.0 12042.0 14933.0 9780.6 11210.0 13112.0 9159.3 11916.0 True False 10184.668451772402 11937.337249676179 11288.751035378773 10401.858826391328 13056.983037286176 11127.78887055309 11731.287212193598 13150.153749191544 10991.415932224667 11571.954118513848 0.8801165600439133 1.0315748859198948 0.9755267709986871 0.898885246161623 1.1283300040393736 0.96161709220311 1.0137689012631699 1.1363814282803586 0.9498323117821229 1.0 13.498344887818662 -6.243068636117374 24.99887343607335 1.0340778413799827 0.9546722948016465 0.26141456885715897 0.06949157850589929 1231.6312502714964 1676001.8836840729 0.019841913156129067 0.02556301460920307 5.713883270384623e-07 6.243068636117374 -0.0794055465783362 S(ph)SPLPAK ddPTM_A459_Selumetinib_30min_R1 2 SSPLPAK 7 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 S(0.993)S(0.007)PLPAK;S(0.926)S(0.074)PLPAK 123.98 0.0068524 179759000.0 32386.0 35397.0 23761.0 22691.0 27866.0 24570.0 30637.0 33065.0 16948.9 28001.0 True False 33140.53078781384 31252.702784381152 20534.3867098304 18728.44281282318 25345.525220141877 24322.84810777506 28326.026424009797 32188.008789743282 28761.045401321902 31595.20110283705 1.0489102658326814 0.9891597993840544 0.6499210637398519 0.5927622600617498 0.8021954073862821 0.7698272920817402 0.8965293916570861 1.0187625862857066 0.9102979059291172 1.0 14.947417828113384 -7.485136525195628 4.004838676296514 0.9726848681104467 0.8004028235668599 0.24761582168556717 0.13081563638280072 0.3501880734763894 12.1231455789393 0.0682639247592429 0.0418440624950664 3.272378079425087e-08 7.485136525195628 -0.17228204454358687 S(ph)SPLPAK ddPTM_A459_Selumetinib_30min_R2 3 SSPLPAK 7 0 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 S(0.994)S(0.006)PLPAK;S(1)SPLPAK;S(0.873)S(0.127)PLPAK 133.58 0.0031852 231438000.0 1793370.0 1220580.0 1350640.0 1819300.0 1762320.0 1465690.0 1771560.0 1981760.0 1594730.0 1414740.0 True False 1693701.6748289217 1314194.5612167197 1263741.292865644 1571508.201532446 1540921.606259305 1667575.4932908972 1853941.0502795435 1987526.5935019713 1913720.5604791474 1373892.7802640395 1.2327757297795976 0.9565481237656356 0.9198252665850488 1.143836130524267 1.1215734068878107 1.2137595576930078 1.3494073750960731 1.4466387931087326 1.392918419813926 1.0 20.389837988751594 -6.776951641326894 1.6058626556040667 1.3331443252239266 1.0450174239054706 0.35210737983036144 0.14028353507588742 0.3494912887510033 1.8694419033160952 0.06045790506436072 0.05429220565538931 1.6712767005436057e-07 6.776951641326894 -0.288126901318456 S(ph)SPLSFPSVPQEETLR ddPTM_A459_Selumetinib_30min_R1 1 SSPLSFPSVPQEETLR 16 0 Q9ULD5 Q9ULD5 ZNF777 Zinc finger protein 777 1 S(0.985)S(0.015)PLSFPSVPQEETLR 222.75 4.8032e-11 10531000.0 982.82 2019.0 1209.6 1495.6 1328.8 1248.6 1250.6 1314.0 587.32 1136.0 True False 1005.7177937651833 1782.6145413923641 1045.3429638571968 1234.4215358890456 1208.610274618694 1236.040217638094 1156.266235136163 1279.1484515264685 996.6391438444022 1281.816665577047 0.7846034622372695 1.3906938404408 0.8155167520673523 0.9630250323928616 0.9428885636110863 0.9642878352511157 0.9020527398242527 0.9979184121081955 0.7775208191693592 1.0 10.32397421699555 S(ph)SPLSWR ddPTM_A459_Selumetinib_30min_R2 2 SSPLSWR 7 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 S(0.5)S(0.5)PLS(0.001)WR;S(0.631)S(0.369)PLSWR 104.06 0.018235 7539500.0 38425.0 35872.0 40888.0 43489.0 41737.0 31465.0 36265.0 37896.0 31231.0 32270.0 True False 36289.492327462416 38623.26705334025 38257.31059548838 37565.723177290514 36493.62492648584 35799.01813916863 37951.39435773425 38006.27108597948 37478.07266704973 31338.281252470788 1.1579924257843994 1.2324628380918337 1.2207852207105991 1.1987167667125567 1.1645062673502107 1.1423414657224107 1.2110234780263218 1.2127745864487374 1.1959198516700678 1.0 14.935638436943437 -10.507934522015393 5.400637555905333 0.9999993599643002 1.1938876271947576 0.8131345762489923 0.027745394436256024 2.2849758493647016e-07 4.297699256690206e-08 0.028711756514233622 0.0069636007764551115 3.105027693615094e-11 10.507934522015393 0.19388826723045738 S(ph)SPNPFITGLTR ddPTM_A459_Selumetinib_30min_R2 2 SSPNPFITGLTR 12 0 J3KQV8;O43426;A0A0D9SGJ6 J3KQV8 SYNJ1 Synaptojanin-1 1 S(0.909)S(0.091)PNPFITGLTR;S(0.988)S(0.012)PNPFITGLTR 209.19 7.3514e-06 20212200.0 47332.0 55857.0 66267.0 67821.0 77133.0 53137.0 58257.0 50398.0 40565.0 57372.0 True False 44701.47692500848 60141.052291436965 62003.45336605429 58583.66280224925 67442.86296223104 60456.13942034019 60966.065934055485 50544.64983616196 48679.1334808002 55715.521289642245 0.8023164082522669 1.0794308461871547 1.1128578164731449 1.051478321412389 1.2104860800210975 1.0850861307759 1.094238454974114 0.9071915449449169 0.8737086606035195 1.0 15.765791670637984 -7.764292911933039 24.997429510350948 0.9178375332559217 1.0710392901683974 0.26694987194658926 0.1016888019656277 92.92742363411772 814028.0375264796 0.053215053005897905 0.0273291122504937 1.7207076442595008e-08 7.764292911933039 0.15320175691247573 S(ph)SPNVANQPPS(ph)PGGK ddPTM_A459_Selumetinib_30min_R2 3 SSPNVANQPPSPGGK 15 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 2 S(0.949)S(0.051)PNVANQPPS(1)PGGK;S(0.757)S(0.243)PNVANQPPS(1)PGGK;S(0.931)S(0.069)PNVANQPPS(1)PGGK 256.66 6.3353e-35 28604000.0 230623.0 207062.0 222900.0 230695.0 238325.0 179714.0 217994.0 211539.0 168780.0 235264.0 True False 217805.89691701674 222942.98959073165 208558.85667517033 199273.94302892813 208384.48284746756 204467.972218737 228131.152946916 212154.54346783346 202540.71610722196 228471.3170307187 0.9533183409965289 0.9758029694412637 0.9128448130192593 0.872205516293037 0.912081593241963 0.8949393511450964 0.9985111300261951 0.9285828358021353 0.8865039110357548 1.0 17.801653530858168 S(ph)SPNVANQPPSPGGK ddPTM_A459_Selumetinib_30min_R2 1 SSPNVANQPPSPGGK 15 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 S(0.5)S(0.5)PNVANQPPSPGGK 163.9 9.9255e-05 5333800.0 26642.0 22055.0 24706.0 26095.0 31577.0 21425.0 21588.0 20073.0 12102.0 18258.0 True False 25161.344296376134 23746.547581997645 23116.44285785891 22540.815983614164 27610.014958038286 24376.099273214324 22591.884775810475 20131.409106735962 14522.738158132497 17730.844100018952 1.419071994228929 1.339279024057984 1.303741814403196 1.271277095239367 1.5571743117412427 1.3747850432675266 1.2741573186460045 1.135389211769926 0.8190663724868561 1.0 14.113973598804884 -7.895615895180294 2.137147088568361 0.9129943541065879 1.3719186898744733 0.8130942417099023 0.08772528934449306 0.1346022823245304 1.1725225157540757 0.06848779871877439 0.025345429192527014 1.2716983412704025e-08 7.895615895180294 0.4589243357678854 S(ph)SPPAPPLPPGSGSPGTPQALPR ddPTM_A459_Selumetinib_30min_R1 1 SSPPAPPLPPGSGSPGTPQALPR 23 0 A0A2R8Y5V0;Q9Y3L3 A0A2R8Y5V0 SH3BP1 SH3 domain-binding protein 1 1 S(0.499)S(0.499)PPAPPLPPGS(0.002)GS(0.001)PGTPQALPR 174.72 2.8287e-13 5633700.0 439.52 402.81 361.9 262.93 399.24 290.45 359.38 216.95 0.0 394.06 True False 449.75996084295497 355.64881793871126 312.75596777440427 217.01421130737282 363.128812491547 287.5283367074996 332.27167726150213 211.19578124708315 0.0 444.64143946944637 1.0115115707155322 0.7998553134477916 0.7033891581216315 0.48806564580736744 0.8166778447929605 0.6466521362709315 0.7472800503209379 0.474979978247384 0.0 1.0 8.796498599972955 -7.8065679850783445 5.317575581903354 0.42001579893486835 0.7348345217124949 0.15200966629213764 0.2590818482593285 0.2902895739366571 18.570212264134764 0.137289357605501 0.06592905679704229 1.5611046412913323e-08 7.8065679850783445 0.3148187227776265 S(ph)SPPAPPLPPGSGSPGTPQALPR ddPTM_A459_Selumetinib_30min_R2 3 SSPPAPPLPPGSGSPGTPQALPR 23 0 A0A2R8Y5V0;Q9Y3L3 A0A2R8Y5V0 SH3BP1 SH3 domain-binding protein 1 1 S(0.496)S(0.496)PPAPPLPPGS(0.006)GS(0.002)PGTPQALPR;S(0.499)S(0.499)PPAPPLPPGS(0.002)GSPGTPQALPR;S(0.499)S(0.499)PPAPPLPPGS(0.001)GS(0.001)PGT(0.001)PQALPR 178.57 3.4165e-16 4607200.0 47619.2 35888.4 42792.8 44628.1 49999.9 35063.7 33411.1 39944.5 30587.4 36252.5 True False 44972.71549876116 38640.924880605984 40039.557837277775 38549.67579223341 43718.46555722261 39893.40639842261 34964.78235283868 40060.73188183204 36705.73468336322 35205.796129693124 1.27742361891457 1.0975728183580435 1.1373001675570058 1.0949809414967326 1.2417973846172952 1.133148821616219 0.9931541449604894 1.137901603879487 1.042604875292254 1.0 15.103525347025125 -1.5228787452803376 0.07679845576010455 0.8739764553222624 1.7313231116639411 0.4313899292014657 0.06652165580021353 223.8892571356881 1.2636979100644326 2.2323845935004525 20.469724366399827 0.029999999999999995 1.5228787452803376 0.8573466563416787 S(ph)SPPFWALPPSAPSER ddPTM_A459_Selumetinib_30min_R2 1 SSPPFWALPPSAPSER 16 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 S(0.5)S(0.5)PPFWALPPSAPSER 113.43 0.0022733 1703400.0 2716.0 3237.9 3555.7 2298.3 2969.8 3517.8 2884.6 2735.3 3039.3 3680.1 True False 2565.0555930094447 3486.236518510552 3326.930133153442 1985.26757521136 2596.707173651142 4002.3450185910533 3018.7396157264634 2743.2592701467083 3647.24492513734 3573.845950951897 0.7177297589803052 0.9754859516488084 0.9309103354797124 0.5554989225773938 0.7265862069291226 1.119898583632298 0.8446753601459569 0.7675930378073623 1.0205378114201853 1.0 11.803261733650448 -6.707856368571247 24.99989912557986 0.9294028825277586 0.7878071102551049 0.2558674222100802 0.14186879236193511 172.475027146102 80469.78485813184 0.04953799396953649 0.04953795221365744 1.9594926167814193e-07 6.707856368571247 -0.14159577227265374 S(ph)SPPLPPPAEER ddPTM_A459_Selumetinib_30min_R1 4 SSPPLPPPAEER 12 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 S(0.87)S(0.13)PPLPPPAEER;S(0.984)S(0.016)PPLPPPAEER;S(0.902)S(0.098)PPLPPPAEER;S(0.91)S(0.09)PPLPPPAEER 150.14 0.00055722 135834000.0 9677.3 10670.300000000001 10624.9 11988.3 11119.1 8326.0 10411.7 9551.0 5629.210000000001 8406.4 True False 9902.762261252123 9421.016315512114 9182.096938398086 9894.768453262004 10113.379368236552 8242.247999403142 9626.337086492242 9297.676453979684 9552.358228768548 9485.443325270147 1.0439957228852126 0.9932078019393786 0.9680197987094692 1.0431529780902675 1.0661999678279162 0.8689365079484465 1.0148536822571845 0.9802047342594695 1.00705448350739 1.0 13.211499487737138 S(ph)SPPLPPPAEER ddPTM_A459_Selumetinib_30min_R2 3 SSPPLPPPAEER 12 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 S(0.826)S(0.174)PPLPPPAEER;S(0.999)S(0.001)PPLPPPAEER;S(0.89)S(0.11)PPLPPPAEER 207.34 9.3555e-06 109837200.0 152737.0 151053.0 156862.0 188036.0 172529.0 145971.0 120264.4 131660.0 110530.0 143330.0 True False 144248.48899465523 162638.27938805195 146769.66969843188 162425.17241980752 150854.36459117042 166077.18025719313 125856.93289938761 132043.10880251357 132639.08846623593 139191.69048393643 1.0363297442048265 1.1684481941601348 1.0544427558006417 1.1669171619016465 1.0837885800990392 1.1931544166162666 0.9041986088523889 0.9486421807467893 0.9529238994445813 1.0 17.086713561661924 -7.2682166588627615 24.99732247994016 0.9471613486182209 1.1174017848756506 0.7081846244919165 0.05209171111491242 273.4137025602971 1008454.6411839756 0.019820448810923205 0.013705492736506949 5.392415410256707e-08 7.2682166588627615 0.17024043625742968 S(ph)SPPLRTPDVLESSGPAVR ddPTM_A459_Selumetinib_30min_R1 2 SSPPLRTPDVLESSGPAVR 19 1 E9PJN1;O75676-2;O75676;A0A0A6YYC0 E9PJN1 RPS6KA4 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-4 1 S(0.491)S(0.491)PPLRT(0.018)PDVLESSGPAVR;S(0.452)S(0.452)PPLRT(0.096)PDVLESSGPAVR 87.15700000000002 0.0018794 63942000.0 1157.8700000000001 1341.3600000000001 1577.1 2180.9 1398.41 969.35 1251.6999999999998 1063.3600000000001 618.28 734.3199999999999 True False 1184.846118177176 1184.3129476186539 1362.9384823901996 1800.0467555632656 1271.9240624093375 959.5992190993803 1157.2832612505476 1035.156238519928 1049.1760026154684 828.5771248825152 1.4299768634635872 1.4293333861788409 1.6449144460552807 2.1724552869094667 1.5350702115867425 1.1581290265953732 1.3967115751773136 1.2493179058819706 1.2662381945002792 1.0 9.694492181134443 -6.6194172108061515 5.276355608460074 1.2438968768629568 1.6732269748831017 0.5023658217696826 0.2148757969360698 0.19954574804935205 8.829395620996955 0.07679462385164086 0.07670656265011565 2.4020541258127386e-07 6.6194172108061515 0.4293300980201449 S(ph)SPPPGYIPDELHQVAR ddPTM_A459_Selumetinib_30min_R1 1 SSPPPGYIPDELHQVAR 17 0 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 S(0.5)S(0.5)PPPGYIPDELHQVAR 133.93 0.00039167 5916700.0 1250.6 1203.9 1092.5 981.6 1049.7 878.19 1023.7 1081.4 789.63 1012.0 True False 1279.7365467560055 1062.946828322074 944.1445006729394 810.1819869140724 954.7548203395878 869.3562059327229 946.4814848144016 1052.7177591177497 1339.9444377066252 1141.9000577147644 1.120708014777657 0.9308580213659887 0.8268188571269672 0.7095034118269989 0.8361106682578663 0.7613242508039874 0.8288654321539788 0.9219000839920338 1.1734340747720062 1.0 10.15722067218518 -8.073824189907576 4.788644552739982 1.0831307176813763 0.8514218453768788 0.3922329253116864 0.11127403390452423 0.2304502118907082 9.63851287754675 0.08315911930003297 0.030398155133116462 8.436762237106341e-09 8.073824189907576 -0.23170887230449744 S(ph)SPPPGYIPDELHQVAR ddPTM_A459_Selumetinib_30min_R2 2 SSPPPGYIPDELHQVAR 17 0 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 S(0.5)S(0.5)PPPGYIPDELHQVAR;S(0.5)S(0.5)PPPGYIPDELHQVAR 193.72 5.7754e-08 8501000.0 19157.0 13300.3 21551.3 20151.6 22890.0 20810.3 24921.3 22653.5 19864.6 15247.6 True False 18092.330631547098 14320.390242794985 20164.712821281253 17406.917316551033 20014.35356080363 23676.729927905333 26080.189830619107 22719.4179345112 23838.0750632985 14807.362169977494 1.2218469720575895 0.9671128509188582 1.3618031753262574 1.1755582876094055 1.3516488170582817 1.5989836444948196 1.7612988411600894 1.534332561985666 1.6098799225449574 1.0 13.854027036837829 -6.51252225687439 2.9557608695821327 1.5496639618339427 1.1792229153562221 0.3281894110754966 0.20866143793381167 0.26122023664228733 4.641677793551968 0.06850668066360131 0.07350696884487189 3.072399905815643e-07 6.51252225687439 -0.3704410464777206 S(ph)SPPPGYVPER ddPTM_A459_Selumetinib_30min_R1 1 SSPPPGYVPER 11 0 J3KRN4;J3QRB6;Q99759;Q99759-2 J3KRN4 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1 S(0.867)S(0.133)PPPGYVPER 137.01 0.0013687 15767000.0 1688.8 2030.7 1526.6 2102.9 1953.1 1710.7 2027.7 1648.2 1043.1 1635.4 True False 1728.1457541672335 1792.9446999531826 1319.296105013555 1735.6679913219284 1776.442449847811 1693.4919111913239 1874.7489564893651 1604.4843818918762 1770.0645149902878 1845.3195201449857 0.9365021804090893 0.9716174789135228 0.71494182476859 0.9405785677623775 0.9626747186353055 0.9177228619238077 1.0159481520804956 0.869488651897972 0.959218441937478 1.0 10.849654927623888 -5.964604589461161 24.99965812276311 0.9491626131727069 0.8746935636616602 0.19267309144745415 0.07307531142811755 308.93464627869565 218197.7484332285 0.020471829748558237 0.030364536430346454 1.0849142424663441e-06 5.964604589461161 -0.07446904951104671 S(ph)SPPPGYVPER ddPTM_A459_Selumetinib_30min_R2 1 SSPPPGYVPER 11 0 J3KRN4;J3QRB6;Q99759;Q99759-2 J3KRN4 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1 S(0.998)S(0.002)PPPGYVPER 142.19 0.00094175 12193000.0 34386.0 40608.0 42731.0 37491.0 46861.0 34822.0 32822.0 36330.0 38524.0 35966.0 True False 32474.96377806434 43722.50302470009 39981.73398199502 32384.661124417653 40973.90223734468 39618.41441735677 34348.28803555918 36435.71428524472 46229.876450495445 34927.568129109524 0.9297802715041841 1.2518049599983643 1.1447042013976698 0.927194845192427 1.173110652476145 1.1343021154781678 0.9834148174470939 1.0431792488546683 1.323592764306035 1.0 15.092078576527554 S(ph)SPPPPPSGSSSR ddPTM_A459_Selumetinib_30min_R2 1 SSPPPPPSGSSSR 13 0 Q5VUA4;Q5VUA4-2 Q5VUA4 ZNF318 Zinc finger protein 318 1 S(0.963)S(0.036)PPPPPSGSSSR 86.262 0.040288 0.0 8742.2 8741.8 9312.1 9999.1 9830.5 7434.0 6488.0 8527.6 7949.6 11210.0 True False 8256.3435217994 9412.267950682708 8712.969624247877 8637.205330590396 8595.504704214947 8457.96602086699 6789.704855728105 8552.413904179823 9539.74213038259 10886.338172922147 0.758413287429891 0.8645944854160483 0.800358163217808 0.7933985876053277 0.7895680409409616 0.7769339778461681 0.6236904226084307 0.7856097953536341 0.8763040407940865 1.0 13.410231137261922 -8.529652887399916 2.6943757511646163 0.9986359597204822 0.774458957782105 0.6085236392075926 0.05707998778603426 0.19292447847265762 3.397709386272019 0.05931343539913368 0.015982104548948273 2.9535689421122198e-09 8.529652887399916 -0.2241770019383772 S(ph)SPPSAGNSPSSLK ddPTM_A459_Selumetinib_30min_R2 1 SSPPSAGNSPSSLK 14 0 P57682;P57682-2 P57682 KLF3 Krueppel-like factor 3 1 S(0.902)S(0.098)PPSAGNSPSSLK 134.04 0.00104 0.0 10223.0 7957.4 8623.9 9222.5 9065.0 9337.6 7221.2 8210.8 7515.9 9164.1 True False 9654.846585911464 8567.706992926234 8069.047662992371 7966.37959030012 7926.173657871776 10623.769641706702 7557.000108536343 8234.692068628885 9019.290011792096 8899.508621808727 1.0848741201566725 0.9627168596624094 0.90668462787021 0.8951482524302607 0.8906304825019506 1.1937478902680738 0.8491480181296196 0.925297386470229 1.0134593262475007 1.0 13.11950996585907 -4.7643908999211835 5.669670301224417 0.9549538600524441 1.0903777059825277 0.14174393676573982 0.09197662776190095 0.2809899637427776 30.645730835478165 0.022858117869611186 0.14870507834794347 1.720319452220509e-05 4.7643908999211835 0.1354238459300836 S(ph)SPQHSLSNPLPR ddPTM_A459_Selumetinib_30min_R1 1 SSPQHSLSNPLPR 13 0 Q86UE8-2;Q86UE8 Q86UE8-2 TLK2 Serine/threonine-protein kinase tousled-like 2 1 S(0.848)S(0.152)PQHSLSNPLPR 160.46 0.00036396 12306000.0 1150.6 957.22 996.9 1138.5 1121.3 1035.7 1091.7 1053.8 607.98 730.0 True False 1177.4067413221342 845.1482374004948 861.5264555797279 939.6823472918418 1019.8786129815937 1025.2817983403604 1009.3521900672873 1025.849800775184 1031.6976548977038 823.7026108021519 1.4294075627313263 1.0260356423751753 1.0459192969423052 1.1408029244641396 1.2381636279972434 1.2447232592135447 1.225384230704748 1.2454128314297483 1.2525123040377386 1.0 9.685979751258248 -6.25106871434494 22.63074846873583 1.2167054531489054 1.1427464943989258 0.007619885857634512 0.12472511656228498 571.8163616974515 1247803.5046277805 0.035962141600099286 0.04580825581139801 5.609592136925014e-07 6.25106871434494 -0.0739589587499796 S(ph)SPQLAK ddPTM_A459_Selumetinib_30min_R2 3 SSPQLAK 7 0 Q13370-2;Q13370 Q13370-2 PDE3B cGMP-inhibited 3,5-cyclic phosphodiesterase B 1 S(0.872)S(0.128)PQLAK;S(0.542)S(0.458)PQLAK;S(0.801)S(0.199)PQLAK 82.279 0.041457 57219000.0 348396.0 713610.0 1027930.0 761630.0 758500.0 220872.0 195818.0 273921.0 269685.0 1298020.0 True False 329033.5450596902 768341.5923821954 961794.1029255609 657894.6801149669 663210.4489239648 251295.113123612 204923.9250060061 274718.06475993723 323629.53562848835 1260542.789939016 0.26102528822175763 0.6095323367954586 0.762999963668105 0.5219138020271372 0.5261308495176512 0.1993546868296073 0.16256800375330385 0.21793632628149642 0.25673823864729356 1.0 20.26561366156666 -10.963885154243838 5.131635013665923 1.0008138725139208 0.39867748400287695 0.4700270803690505 0.1938715283901979 0.0020798787431367655 0.00022656269988027044 0.21627671084427325 0.05238880634251112 1.0867129583088822e-11 10.963885154243838 -0.6021363885110439 S(ph)SPQLDPLR ddPTM_A459_Selumetinib_30min_R1 4 SSPQLDPLR 9 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.932)S(0.068)PQLDPLR;S(0.981)S(0.019)PQLDPLR;S(0.5)S(0.5)PQLDPLR;S(0.818)S(0.182)PQLDPLR 191.33 0.0007829 304590000.0 25269.9 36242.4 20955.1 20959.8 24862.8 22820.5 30045.4 26082.5 13322.099999999999 26439.4 True False 25858.639503334085 31999.122959365333 18109.51251812495 17299.564394174395 22613.96412988386 22590.946489356153 27779.051288309678 25390.707372099776 22606.630692313385 29833.15453156496 0.8667752341099014 1.0726027288032405 0.607026404095624 0.5798771422536158 0.7580145138844491 0.7572429682370266 0.9311469646603433 0.8510902641970076 0.7577686988613439 1.0 14.864628914595214 -9.664850063283202 11.267291312306066 0.9999998953880301 0.7971069334206836 0.16229385446596267 0.13770140698388963 0.0 0.0 0.14436897166131038 0.035014618777728566 2.1634653140058282e-10 9.664850063283202 -0.20289296196734652 S(ph)SPQLDPLR ddPTM_A459_Selumetinib_30min_R2 3 SSPQLDPLR 9 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.985)S(0.015)PQLDPLR;S(0.912)S(0.088)PQLDPLR;S(0.769)S(0.231)PQLDPLR 155.58 0.00082624 565658000.0 273876.0 211891.0 262024.0 295784.0 294960.0 272989.0 306381.0 322345.0 301824.0 241525.0 True False 258655.06833249412 228142.3583630495 245165.661110161 255497.70894413991 257904.48782414355 310590.7568025905 320628.3235824339 323282.9705829128 362197.2336671768 234551.54569268646 1.1027642882020847 0.9726747171471026 1.0452528052464056 1.0893030279958056 1.0995642218536241 1.324189767691968 1.3669844836687914 1.3783024521462066 1.5442116682604767 1.0 17.839545482650053 -6.729682166892166 2.847066989641425 1.3553635387034737 1.0486979454134298 0.49137497011282005 0.13158320359947637 0.19846404427933206 3.2955721442342027 0.04585881637678444 0.04339515727633298 1.8634503811480367e-07 6.729682166892166 -0.30666559329004395 S(ph)SPQLDPLRK ddPTM_A459_Selumetinib_30min_R2 1 SSPQLDPLRK 10 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.5)S(0.5)PQLDPLRK 82.85 0.021357 227730000.0 114780.0 83955.0 113340.0 131670.0 117390.0 98700.0 135240.0 142210.0 110780.0 108570.0 True False 108400.9871007451 90394.07854212704 106047.82779526165 113736.31885658093 102642.41872008466 112295.0290906069 141528.92797297606 142623.80755586718 132939.09545181922 105435.30200126304 1.028128008771166 0.8573416761403517 1.005809494375909 1.078730906041493 0.973510928235925 1.0650610085914267 1.3423296114927488 1.3527139852471675 1.260859436341603 1.0 16.685998467550192 -7.101957183843692 4.301245676229251 1.2669134574517003 0.9894458824745143 0.5482164407917495 0.10604848163150121 0.15786560558866558 4.96285446932875 0.0408049224578545 0.031509404966208646 7.907565831431185e-08 7.101957183843692 -0.277467574977186 S(ph)SPSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R1 1 SSPSARPPDVPGQQPQAAK 19 1 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 S(0.499)S(0.499)PS(0.001)ARPPDVPGQQPQAAK 189.56 1.3065e-14 8119400.0 3107.3 4143.0 3469.3 3256.7 3227.4 3452.2 3459.6 3222.1 1963.6 3921.6 True False 3179.6940442467135 3657.935633971556 2998.1881155008027 2687.978480830339 2935.4822398437477 3417.474002346809 3198.63958666006 3136.639441144165 3332.0857843302933 4424.975559618794 0.7185788941443645 0.8266566865030736 0.6775603786067222 0.6074561191614591 0.6633894809797855 0.7723147746925002 0.722860396303662 0.7088489865951672 0.7530178956779024 1.0 12.111453771470346 -9.462318450364085 0.8648459754428645 1.0048145402432844 0.7094789152491869 0.7003203528832744 0.05612826166272214 3.2942702392918526 2.52126234497405 0.10778447725197404 0.020046941830067395 3.4489075232541544e-10 9.462318450364085 -0.2953356249940975 S(ph)SPSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R2 2 SSPSARPPDVPGQQPQAAK 19 1 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 S(0.448)S(0.448)PS(0.103)ARPPDVPGQQPQAAK;S(0.467)S(0.467)PS(0.066)ARPPDVPGQQPQAAK 83.404 0.0025087 91873000.0 76518.0 67245.0 81389.0 74109.0 82165.0 79132.0 82820.0 87440.0 75682.0 67040.0 True False 72265.43588582345 72402.47527324545 76152.52034964308 64015.226354844315 71842.69813558018 90031.71471122494 86671.29410471655 87694.43592352876 90820.5147317621 65104.381009161574 1.109993440774042 1.1120983588348206 1.1696988615701114 0.9832706395877723 1.1035002103079727 1.382882585099082 1.331266694518147 1.346982101115258 1.394998513525253 1.0 15.990467008155848 -6.748523531711616 24.283742087041933 1.315414889796429 1.0944861510185493 0.41555596133085027 0.1141391849493451 137.06213627969385 257696.67409253845 0.035616248494977444 0.03538232267169825 1.7843353039102036e-07 6.748523531711616 -0.22092873877787977 S(ph)SPSGITHVIASNAR ddPTM_A459_Selumetinib_30min_R2 1 SSPSGITHVIASNAR 15 0 Q9BQI6 Q9BQI6 ANKRD32 Ankyrin repeat domain-containing protein 32 1 S(0.5)S(0.5)PSGITHVIASNAR 144.08 0.00021248 0.0 7275.2 7846.8 11689.0 11348.0 11274.0 10803.0 9184.6 9859.6 10435.0 11133.0 True False 6870.8735089331 8448.624328561289 10936.942466020922 9802.382823608106 9857.65932916122 12291.015190129958 9611.702098939631 9888.289803655356 12522.291578260829 10811.561362992174 0.6355116784937286 0.7814434978356424 1.0115969468996335 0.9066574655129396 0.9117701873203858 1.1368399787473744 0.8890207229309502 0.9146033095185342 1.1582315595159514 1.0 13.400287265987815 -5.018558356966542 2.2798522528540794 0.9853812306525058 0.6174856674533679 0.6266101433582714 0.0901816125118632 0.249942292930345 2.1607302536928636 0.024018973273685695 0.15155272596195626 9.581679568248467e-06 5.018558356966542 -0.36789556319913796 S(ph)SPSHSTTSGETDPTTIFPCK ddPTM_A459_Selumetinib_30min_R2 2 SSPSHSTTSGETDPTTIFPCK 21 0 Q05GC8;Q96PN7-2;Q96PN7-3;Q96PN7-4;Q96PN7-5;Q96PN7 Q05GC8 BCAR2;TRERF1 Transcriptional-regulating factor 1 1 S(0.472)S(0.472)PS(0.014)HS(0.014)T(0.014)T(0.014)S(0.002)GETDPTTIFPCK;S(0.365)S(0.365)PS(0.052)HS(0.052)T(0.052)T(0.052)S(0.052)GET(0.01)DPTTIFPCK 102.94 0.00013176 8454900.0 32118.0 27184.0 53755.0 69124.0 74865.0 45131.0 36555.0 49389.0 46326.0 58763.0 True False 30333.01013854099 29268.92538966329 50296.461824018734 59709.19195444896 65459.78939840822 51347.38559157222 38254.87993235833 49532.71381321091 55592.49445658943 57066.3595053902 0.5315392536241231 0.5128928083610922 0.8813679768597816 1.0463115655521906 1.1470819229711897 0.8997837962087315 0.6703578126224254 0.867984470054241 0.9741727865317648 1.0 15.800352910129197 -5.295422379928006 4.62279407245549 0.9348123529519567 0.5174619985013262 0.6632028433316255 0.118328821611366 0.12449037858237787 6.602507754796245 0.03550413179289939 0.08286704920270652 5.064978661880427e-06 5.295422379928006 -0.4173503544506305 S(ph)SPSHTTNGCQGEK ddPTM_A459_Selumetinib_30min_R2 2 SSPSHTTNGCQGEK 14 0 Q8N8R5 Q8N8R5 C2orf69 UPF0565 protein C2orf69 1 S(0.49)S(0.49)PS(0.02)HTTNGCQGEK;S(0.44)S(0.44)PS(0.119)HT(0.001)TNGCQGEK 101.78 0.0074765 1075400.0 6849.5 4954.8 6373.8 6468.9 6466.0 8488.7 9310.3 19483.4 10180.5 13808.0 True False 6468.832210720979 5334.817227806936 5963.71664726873 5587.824660525066 5653.683273226576 9657.941372253646 9743.247398009458 19540.09346834949 12216.884466936694 13409.327162507494 0.4824128856224678 0.39784376674193583 0.4447439140677613 0.4167117852227989 0.4216231884500727 0.7202405650342599 0.7266022582588333 1.4572016352157944 0.9110736369454187 1.0 13.710949228748088 -7.290191034172462 1.7239297767454704 1.1270006845120117 0.43570140386729145 0.7582724444165192 0.16086470168354697 0.1607194766061259 0.9307139661496702 0.08337209348800027 0.05007245074076526 5.126358400130799e-08 7.290191034172462 -0.6912992806447202 down S(ph)SPSIICMPK ddPTM_A459_Selumetinib_30min_R1 1 SSPSIICMPK 10 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 S(0.952)S(0.048)PSIICMPK 225.22 4.011800000000001e-05 40993000.0 2220.9 2456.2 1897.7 1902.4 1790.8 2318.5 2074.3 2174.3 1009.2 2190.2 True False 2272.6426488808675 2168.626962143598 1640.002763319943 1570.1815524707943 1628.8224561914194 2295.1779950295677 1917.8338809714899 2116.630500878235 1712.5386909483248 2471.3335043546217 0.9196017635322589 0.8775128724319731 0.6636104598712276 0.6353580161091372 0.659086462155491 0.9287204624488525 0.7760319995630554 0.8564730325343055 0.6929613862033351 1.0 11.271073998935424 -6.759963654419046 24.999915988235994 0.8371915946829581 0.7467772387649222 0.1514664940755216 0.11566309678116388 93.33632664263497 1581196.557755457 0.04140786979081338 0.03930259453344812 1.7379462692888224e-07 6.759963654419046 -0.09041435591803593 S(ph)SPSIICMPK ddPTM_A459_Selumetinib_30min_R2 1 SSPSIICMPK 10 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 S(0.873)S(0.127)PSIICMPK 123.96 0.0039915 7779300.0 66341.0 59420.0 66259.0 68220.0 64104.0 55857.0 59192.0 66888.0 54673.0 53717.0 True False 62654.03280406462 63977.32293458628 61995.96807734458 58928.318313935924 56050.68242296885 63550.79473063856 61944.545286722896 67082.63300609551 65609.12769125577 52166.05063647271 1.2010499556632925 1.226416839189577 1.1884351473983181 1.1296296651741404 1.0744666644129686 1.218240483135329 1.1874493953623815 1.285944252777948 1.2576978109472623 1.0 15.670823594152397 S(ph)SPSILAVQR ddPTM_A459_Selumetinib_30min_R2 2 SSPSILAVQR 10 0 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(0.939)S(0.061)PSILAVQR;S(0.668)S(0.332)PSILAVQR 181.87 0.00014224 15065100.0 65398.0 59697.0 68070.0 80235.0 82184.0 63083.0 64765.0 74631.0 57929.0 72151.0 True False 61763.44096893655 64275.56794389091 63690.45030901219 69306.8545869047 71859.31118571802 71772.11063954163 67776.70082941288 74848.16385417292 69516.41867149704 70067.81315918866 0.881480928034885 0.917333723515272 0.9089829900115821 0.9891396842862052 1.0255680596518577 1.0243235432006552 0.967301500839329 1.0682246309603478 0.9921305594847253 1.0 16.096464249469747 -5.815066885508109 3.0126982050584545 1.0144799005309613 0.9011022171196414 0.7845499833608441 0.025938501648126326 0.10676016916479232 1.9675317956638094 0.0072924668625180345 0.012246146909522318 1.5308516777113982e-06 5.815066885508109 -0.11337768341131982 S(ph)SPSKCPSLDDR ddPTM_A459_Selumetinib_30min_R1 2 SSPSKCPSLDDR 12 1 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 S(0.753)S(0.247)PS(0.001)KCPSLDDR;S(0.498)S(0.498)PS(0.004)KCPSLDDR 183.06 0.00049498 22788800.0 5801.700000000001 6480.9 7106.7 7696.9 6422.5 6687.6 6061.700000000001 6316.6 3502.4 5186.5 True False 5936.868321856969 5722.113215111333 6141.6491743088145 6352.7809037071365 5841.586008984469 6620.328815854971 5604.461088697335 6149.063248791543 5943.316994825025 5852.237795788168 1.0144612247523006 0.9777649874770152 1.0494531132567673 1.0855302066295405 0.9981798779927629 1.1312474043039733 0.9576612031607539 1.05071999179818 1.015563140496855 1.0 12.514772676803263 -5.267924098767147 24.601843199829606 1.0388715541695528 0.9961131053890063 0.10181826404146055 0.04684143859591142 774.685053562492 2939027.9980821013 0.011587549966554238 0.025151327156073898 5.39604920512582e-06 5.267924098767147 -0.042758448780546465 S(ph)SPSPALEQPFR ddPTM_A459_Selumetinib_30min_R2 1 SSPSPALEQPFR 12 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.936)S(0.002)PS(0.062)PALEQPFR 145.83 0.00067258 18290000.0 43643.0 43314.0 45163.0 44631.0 50181.0 30064.0 36636.0 32881.0 30696.0 28731.0 True False 41217.496776771426 46636.04452353871 42257.261749756435 38552.180807230645 43876.814156168104 34205.043106180376 38339.64659285676 32976.67826625741 36836.05771790075 27901.461377897056 1.4772522563790529 1.6714552650809462 1.51451786619434 1.3817262216154333 1.5725632991727947 1.2259229953194095 1.3741089068269599 1.1818978876992026 1.3202196551282255 1.0 14.768053066744802 -7.371158833568042 0.21651966534164532 0.9179631629755425 1.748062797021991 0.7230425495817504 0.0998425258280962 1.5444782713941445 0.2634111464130711 0.30973175345749654 0.48012060186274397 4.25442788419731e-08 7.371158833568042 0.8300996340464486 S(ph)SPSVLIHSLGK ddPTM_A459_Selumetinib_30min_R1 2 SSPSVLIHSLGK 12 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 S(0.5)S(0.5)PSVLIHSLGK;S(0.497)S(0.497)PS(0.006)VLIHSLGK 125.84 0.0018652 52845000.0 12092.599999999999 14265.8 9853.2 10711.1 16595.0 11045.0 15376.6 13697.3 4310.4 10167.8 True False 12374.334051896436 12595.553504009513 8515.18955975342 8840.607457248707 15093.985180085216 10933.897328057616 14216.73068222832 13334.003108899155 7314.433980839931 11472.93617275907 1.0785673227466928 1.0978491742955867 0.7421979370870713 0.7705618966345799 1.315616591324184 0.9530164870975811 1.239153645427229 1.1622136572640347 0.6375381045182716 1.0 13.485947035052286 S(ph)SPSVLIHSLGK ddPTM_A459_Selumetinib_30min_R2 1 SSPSVLIHSLGK 12 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 S(0.5)S(0.5)PSVLIHSLGK 158.31 0.00029954 34989000.0 207620.0 127760.0 251610.0 271080.0 386330.0 243570.0 224370.0 277790.0 274570.0 274880.0 True False 196081.31156871148 137558.7811868519 235421.6865322548 234158.43636091705 337795.7715659793 277119.5565916832 234803.64958072043 278598.3229093897 329491.67212679173 266943.50017598865 0.7345423710989043 0.515310472426424 0.8819157850895325 0.8771835096435864 1.2654204779036748 1.0381206375468433 0.8796005500262067 1.043660260413598 1.234312399101558 1.0 18.026174895594956 -5.638831469571663 1.9364583298910907 1.0630115236290294 0.6281249267437441 0.6378009949179777 0.1276024144732392 0.21182445602659702 1.5953438045263795 0.03866648624309184 0.08864991090239911 2.2970398544807553e-06 5.638831469571663 -0.4348865968852853 S(ph)SPTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R1 1 SSPTQETQAPFIAK 14 0 O15231-5 O15231-5 ZNF185 Zinc finger protein 185 1 S(0.5)S(0.5)PTQETQAPFIAK 111.12 0.0040341000000000005 6502900.0 3339.3 3961.8 4198.9 4106.1 4280.8 3741.7 4640.8 4338.7 2263.8 3596.4 True False 3417.099192853296 3497.950614209147 3628.7124429067326 3389.046716043066 3893.6023958366236 3704.061895191776 4290.740719670487 4223.623581916199 3841.5032585897925 4058.0329719025463 0.8420580159187917 0.8619818119834514 0.8942047706442037 0.83514518967897 0.9594802266998752 0.9127727450314884 1.0573449622955724 1.040805634444123 0.9466417067549756 1.0 11.986564871838237 -6.699505440146473 1.382716849604923 1.0111430835604187 0.860434609968834 0.712417947769745 0.04056604413311138 0.21864245153687092 0.8737899488626737 0.018154401346664732 0.01732260193360785 1.9975357463538707e-07 6.699505440146473 -0.15070847359158468 S(ph)SPTSASACGAQGLR ddPTM_A459_Selumetinib_30min_R2 1 SSPTSASACGAQGLR 15 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;A0A2R8YFX5;H0YHA8 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.493)S(0.493)PT(0.008)S(0.006)ASACGAQGLR 115.0 0.0024244 10536000.0 17627.0 15967.0 13666.0 17643.0 25773.0 15017.0 18914.0 18837.0 15570.0 17823.0 True False 16647.36190647183 17191.617558003018 12786.744438415766 15239.992964127405 22535.165326456616 17085.45543924664 19793.538477379992 18891.812551366766 18684.43506214864 17308.4036802847 0.9618080450385014 0.9932526347063011 0.7387593145276954 0.880496737055345 1.3019782611221107 0.98711907549903 1.1435796647108485 1.0914820858312695 1.0795007677935846 1.0 14.079185053489452 -6.209969189986968 24.995907375797824 1.1016581149017104 0.8896399974944155 0.4953583195490395 0.10233574611963966 289.485353012925 140585.00566745002 0.029650656716329108 0.03827879087252505 6.166387463130244e-07 6.209969189986968 -0.21201811740729493 S(ph)SPVCSTAPVETEPK ddPTM_A459_Selumetinib_30min_R1 2 SSPVCSTAPVETEPK 15 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 S(0.744)S(0.256)PVCSTAPVETEPK;S(0.801)S(0.199)PVCSTAPVETEPK 261.45 1.7953999999999998e-36 27256000.0 6396.5 8257.1 6460.6 6525.4 5585.9 6100.9 6767.4 7340.1 4461.200000000001 7276.1 True False 6545.52600457764 7290.35489337835 5583.286005535554 5385.861386928579 5080.656331270741 6039.530485173987 6256.929569535001 7145.416703995001 7570.330566843706 8210.058310215802 0.7972569447445972 0.8879784549528642 0.6800543667988634 0.6560076900095746 0.6188331604111587 0.7356257723113829 0.7621053752747997 0.8703247204838894 0.9220800000194785 1.0 13.00317675314025 -8.013002127885482 1.4598005987089144 0.9842722083291962 0.7257122078709427 0.6348433270034319 0.07166100029373766 0.3023718987849047 1.1550199334684392 0.07311969295251776 0.024384657302168003 9.705052121102157e-09 8.013002127885482 -0.25856000045825345 S(ph)SPVCSTAPVETEPK ddPTM_A459_Selumetinib_30min_R2 3 SSPVCSTAPVETEPK 15 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 S(0.5)S(0.5)PVCSTAPVETEPK;S(0.876)S(0.124)PVCSTAPVETEPK;S(0.696)S(0.304)PVCSTAPVETEPK 342.38 4.487499999999998e-146 50851100.0 141122.0 102598.0 118155.0 131825.0 129195.0 107006.0 143083.0 145306.0 110234.0 96634.0 True False 133279.0041961261 110466.93669543402 110553.03593743689 113870.2075891911 112964.36908204561 121745.10519624599 149736.6430135859 145728.81640329678 132283.88019530446 93843.92533471544 1.4202198354422686 1.1771346552419761 1.178052127968056 1.2133998783943385 1.2037472716441986 1.2973147144262638 1.5955922823935222 1.5528849191199345 1.4096158032977018 1.0 16.517975739702827 -7.0187355372969265 17.771906477493786 1.4371491311025049 1.2323646271273767 0.13196742007961415 0.16517410308525382 24.87429479714475 23593.973915552182 0.0591822354751127 0.04708286377885077 9.577771301013485e-08 7.0187355372969265 -0.20478450397512815 S(ph)SPVEFECINEK ddPTM_A459_Selumetinib_30min_R1 2 SSPVEFECINEK 12 0 O75131;H0YB26 O75131 CPNE3 Copine-3 1 S(0.991)S(0.009)PVEFECINEK;S(0.945)S(0.055)PVEFECINEK 279.75 5.0733e-44 35438000.0 4464.1 5754.2 5090.6 4859.9 5134.799999999999 3834.7 4579.1 4917.8 2577.3999999999996 4357.5 True False 4568.104844373493 5080.495588944994 4399.324480664226 4011.2096966215395 4670.358246622573 3796.1263996290195 4233.694800345439 4787.363968734299 4373.659554152013 4916.827570644351 0.9290756648956151 1.0332873211332068 0.8947485787238404 0.8158125618580254 0.9498722864528929 0.7720682381244328 0.8610622885420024 0.973669281655715 0.8895287644953642 1.0 12.263512046503916 -2.803376211833451 0.0012077807174500673 1.8043232448975959 1.0740171701810724e-06 0.004765297542420721 0.0774123569126326 13755679.634369351 1696.8488012276107 1250457.709328617 1284693.8204446798 0.0015726199768411509 2.803376211833451 -1.8043221708804258 S(ph)SPVEFECINEK ddPTM_A459_Selumetinib_30min_R2 2 SSPVEFECINEK 12 0 O75131;H0YB26 O75131 CPNE3 Copine-3 1 S(0.5)S(0.5)PVEFECINEK;S(0.999)S(0.001)PVEFECINEK 237.41 3.6090999999999997e-13 22520000.0 93380.0 79169.0 91249.0 95831.0 93618.0 66690.0 82897.0 86138.0 61628.0 79705.0 True False 88190.31342975772 85241.00773154273 85378.13868439941 82778.65248230431 81856.86988446114 75875.94214845561 86751.87475728919 86388.64731908636 73955.32203019247 77403.70955153974 1.1393551283357506 1.10125222971109 1.10302386253917 1.069440379045214 1.0575316139074218 0.9802623490277703 1.1207715400193439 1.1160789039647248 0.9554493248278866 1.0 16.240115088339905 -1.5228787452803376 0.17167260104115645 1.0029407619681132 1.5288548340090913 0.3654662845537239 0.048770952206089006 76.41198428969197 0.8328698881134258 0.1285250407863506 10.345635411471878 0.029999999999999995 1.5228787452803376 0.5259140720409781 S(ph)SPVESLK ddPTM_A459_Selumetinib_30min_R2 1 SSPVESLK 8 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B1AKL5 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.899)S(0.101)PVESLK 109.29 0.012513 11209000.0 91936.0 71125.0 88138.0 98255.0 106200.0 91091.0 104570.0 111210.0 97655.0 74643.0 True False 86826.56516896772 76580.05879707943 82467.29703739844 84872.4995006712 92858.20655995395 103637.95840823167 109432.712201524 111533.6026881933 117188.72870867874 72487.86264419528 1.1978083226864278 1.0564535358556588 1.1376704185938955 1.1708511798349688 1.281017306521313 1.4297284349096593 1.509669456508485 1.5386521083626508 1.6166669071744666 1.0 16.145451830278056 -6.52592087062867 1.8560183165972421 1.4636605760137904 1.1274233385548085 0.3889694802943987 0.16034901973611582 0.29864400874066377 2.077760900083716 0.057551450317323 0.06244229420710474 2.979059170852627e-07 6.52592087062867 -0.33623723745898193 S(ph)SPVESLKK ddPTM_A459_Selumetinib_30min_R1 2 SSPVESLKK 9 1 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B1AKL5 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.987)S(0.013)PVESLKK;S(0.953)S(0.047)PVESLKK 141.91 0.0038888 207730000.0 8942.2 9389.2 8477.8 9135.0 8786.1 7881.200000000001 8976.0 9308.8 4859.1 8057.0 True False 9150.53586150772 8289.908099079337 7326.561325222013 7539.743735187502 7991.3988063119405 7801.922283557059 8298.933093380943 9061.900384756153 8245.53780537753 9091.19443182594 1.0065273523877172 0.9118612698523415 0.8058964506988874 0.8293457797792547 0.8790262782562546 0.858184514924082 0.9128539880665744 0.996777755960511 0.9069806907343239 1.0 13.150254137680703 -7.550907788411261 5.293421485497109 0.9633876263979314 0.8776567894650188 0.3186623628000661 0.05595304085981518 0.23351378776714563 17.904021350993627 0.02802995381011328 0.01627675832038372 2.812497930713503e-08 7.550907788411261 -0.08573083693291261 S(ph)SPVGGGPR ddPTM_A459_Selumetinib_30min_R1 1 SSPVGGGPR 9 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.5)S(0.5)PVGGGPR 106.88 0.012912 5332600.0 2080.3 2183.4 2252.7 2315.9 2154.2 2134.7 1801.0 1988.6 1437.3 1850.9 True False 2128.766942440845 1927.7665129648778 1946.7957131953603 1911.4715398271196 1959.3529903549002 2113.226856152521 1665.1491200065823 1935.8558681168463 2438.9931237614232 2088.4810442927433 1.0192895684919872 0.9230471678126766 0.9321586703003263 0.9152448594401452 0.9381713067060314 1.0118487126935634 0.797301524261849 0.9269204876946427 1.1678311040583946 1.0 11.028238333870735 -8.240811371586284 24.510935999713105 1.083915540487596 0.9303239587226616 0.4379405360899221 0.06833493913961947 474.6171318543488 563959.4225368703 0.044731311407859416 0.016861264309488498 5.743658740774933e-09 8.240811371586284 -0.15359158176493437 S(ph)SPVGGGPR ddPTM_A459_Selumetinib_30min_R2 2 SSPVGGGPR 9 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.5)S(0.5)PVGGGPR;S(0.933)S(0.067)PVGGGPR 150.81 0.0012801 38776000.0 57148.0 58737.0 56753.0 66370.0 72850.0 50101.0 64268.0 78244.0 60210.0 71243.0 True False 53971.94294156981 63241.93903077741 53101.57376799433 57330.29150536389 63697.93171273673 57001.95797840417 67256.58934462605 78471.67708600851 72253.68240796213 69186.02947845598 0.7800988631436969 0.9140853942264526 0.7675187341763812 0.8286397114784008 0.9206762144454582 0.8238940492481095 0.9721122869981902 1.1342127547649488 1.0443391961156174 1.0 16.078193127860118 -7.455127686256368 3.557072279062559 1.0667663480654297 0.842961072354215 0.7589464252070125 0.05616934838406837 0.1100910449369318 2.716193339638882 0.025589485853801053 0.015749541938081008 3.506487650887668e-08 7.455127686256368 -0.22380527571121467 S(ph)SPVKVGEK ddPTM_A459_Selumetinib_30min_R1 1 SSPVKVGEK 9 1 P49916-4;P49916-3;P49916-2;P49916 P49916-4 LIG3 DNA ligase 3 1 S(0.882)S(0.118)PVKVGEK 122.33 0.028388 54957000.0 5175.3 4290.3 6517.4 5967.7 4849.4 5699.3 4603.3 5094.2 3658.2 4323.7 True False 5295.874420619191 3787.9896814936437 5632.372877515622 4925.55322260301 4410.772626231107 5641.970216550365 4256.069374861906 4959.085267706342 6207.698215643245 4878.6890114044745 1.085511785694784 0.7764359795508178 1.1544849168187046 1.0096059025465622 0.9040897290072064 1.1564521131315475 0.8723797243302194 1.0164790697078523 1.2724111336328396 1.0 12.252277807277524 -8.0286850299803 24.173310051207636 1.1389521840427064 0.9916717105920854 0.15743124616613635 0.12966684934937292 789.3463439504998 665187.7094289521 0.08121357283012606 0.03084660489394775 9.360843187523727e-09 8.0286850299803 -0.147280473450621 S(ph)SPVLQHK ddPTM_A459_Selumetinib_30min_R1 3 SSPVLQHK 8 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.792)S(0.208)PVLQHK;S(0.5)S(0.5)PVLQHK;S(0.5)S(0.5)PVLQHK 131.52 0.002347 55084000.0 24228.5 29907.1 28210.5 23572.5 22840.5 25242.6 20946.0 26982.1 26487.9 22691.2 True False 24792.976909545723 26405.562828566413 24379.66904918439 19456.00538562753 20774.580807817798 24988.682362447013 19366.026356278646 26266.44705778714 44948.031700327134 25603.836551005184 0.9683305414075678 1.0313127400248832 0.95218812230026 0.7598863298033242 0.8113854643007478 0.9759741401515071 0.7563720506377921 1.025879344506124 1.755519396899232 1.0 14.644072383462248 -8.018862227929317 23.17369738754749 1.382073293103582 0.8956909012945109 0.5009306428337476 0.19071160403039183 215.9420803091288 265298.02241359913 0.11540406259428718 0.0454190510028031 9.574977719734707e-09 8.018862227929317 -0.48638239180907106 S(ph)SPVLQHK ddPTM_A459_Selumetinib_30min_R2 2 SSPVLQHK 8 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.5)S(0.5)PVLQHK;S(0.71)S(0.29)PVLQHK 128.86 0.0027931 15884700.0 110979.0 82981.0 83729.0 90609.0 84309.0 75559.0 147977.0 238697.0 115905.0 192989.0 True False 104811.23146413661 89345.37587403065 78341.9672972422 78267.89789075665 73717.34968797705 85966.5663936896 154858.22371086286 239391.56875158456 139089.23865628405 187416.9061243598 0.5592410718518077 0.4767199380334763 0.41800907355315464 0.4176138615735246 0.39333351090035695 0.4586916312482866 0.8262767053048419 1.27732110033199 0.7421381642272543 1.0 17.515891573013754 -7.375106685829929 3.5447415670354454 1.0137779148499675 0.44772745792253243 0.7924851426941887 0.1291413359624762 0.09924368219254223 2.2859390726675453 0.055247699643247904 0.03549576194940002 4.2159292505510045e-08 7.375106685829929 -0.566050456927435 S(ph)SPVPPVPER ddPTM_A459_Selumetinib_30min_R1 2 SSPVPPVPER 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 S(0.5)S(0.5)PVPPVPER;S(0.869)S(0.131)PVPPVPER 117.14 0.0061178000000000005 32185000.0 6749.6 8583.7 7554.799999999999 7961.7 7667.0 6407.6 7746.0 7483.0 3780.6 6267.200000000001 True False 6906.852547564639 7578.716413546137 6528.899655545925 6571.33855461876 6973.521203718795 6343.145361635312 7161.712983659622 7284.526531790385 6415.402075900948 7071.656167697595 0.9766951876300551 1.0717031815212859 0.9232490240926997 0.9292502914148709 0.9861227749693109 0.8969815855315441 1.0127348974308727 1.0301019109307312 0.9071993778777975 1.0 12.787832415554252 -10.62200139417918 14.835337232087193 1.0000042471075672 0.9721252458849653 0.025361266279932737 0.05406672060098764 0.0 0.0 0.052490992361347986 0.012730935641136917 2.387803617535021e-11 10.62200139417918 -0.027879001222601896 S(ph)SPVPPVPER ddPTM_A459_Selumetinib_30min_R2 3 SSPVPPVPER 10 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 S(0.989)S(0.011)PVPPVPER;S(0.911)S(0.089)PVPPVPER;S(0.517)S(0.483)PVPPVPER 120.63 0.0050284 122495000.0 374080.0 309231.0 382220.0 464170.0 460760.0 380410.0 332602.0 400050.0 364780.0 360520.0 True False 353290.131160888 332948.0233656183 357628.38132966985 400949.2452620888 402875.2095533373 432808.0244818412 348068.65203836013 401214.07926815766 437746.1928047894 350110.85085654777 1.0090807819768 0.9509788758362087 1.021471857997918 1.14520656609518 1.1507075789502133 1.2362028295409138 0.994166993644466 1.145962995110222 1.2503074147340518 1.0 18.417452249811745 -5.664072716698104 3.893972523102784 1.137520257141979 0.9811916373342411 0.3878959748925862 0.08008968798128087 0.21549330356708646 6.112948996243846 0.021994755043102738 0.03961121430787117 2.1673411826645237e-06 5.664072716698104 -0.15632861980773782 S(ph)SPVPPVPERR ddPTM_A459_Selumetinib_30min_R1 1 SSPVPPVPERR 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 S(0.5)S(0.5)PVPPVPERR 105.66 0.0059386000000000005 50274000.0 893.21 967.58 1094.3 1322.0 1138.5 1135.9 1125.5 951.76 461.34 685.57 True False 914.0200551158907 854.2952837842615 945.7000705596321 1091.1375170134525 1035.5228760185007 1124.47387731468 1040.6026288547516 926.5162330478169 782.8602850595522 773.5695875173029 1.1815615167206224 1.104354795702401 1.2225145427378619 1.4105227695356448 1.33862924904004 1.4536169666695025 1.3451958888333053 1.1977154324556392 1.0120101639104853 1.0 9.595387266905357 -8.143616850985259 2.978735543557855 0.9990820720223382 1.2954682156345174 0.5676760936548564 0.09910791859895789 0.2263420697048415 3.592301546607178 0.09614649671168646 0.030511417878542998 7.184278326574148e-09 8.143616850985259 0.2963861436121792 S(ph)SPVPVSDTQK ddPTM_A459_Selumetinib_30min_R2 2 SSPVPVSDTQK 11 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 S(0.995)S(0.005)PVPVSDTQK;S(0.928)S(0.072)PVPVSDTQK 190.53 1.9828e-05 16781900.0 64381.0 50899.0 77344.0 75885.0 85547.0 72520.0 84155.0 88616.0 80186.0 68925.0 True False 60802.96175756297 54802.78963391969 72367.77124577986 65549.33209107342 74799.82106011662 82508.97172898501 88068.37424996903 88873.85788883148 96225.44058403655 66934.95616134322 0.908388758946829 0.8187469265210308 1.081165588147113 0.9792989470713953 1.1175001127933146 1.2326738741727332 1.3157306630288188 1.3277644893739182 1.4375962292720437 1.0 16.030472221354046 -6.314210570118362 0.9766399891968105 1.3028833098423778 0.890268641266697 0.612121067271844 0.11918881651451153 0.3362163179160187 0.6827851523302034 0.05489778792297633 0.08128415993780848 4.850532623404431e-07 6.314210570118362 -0.41261466857568074 S(ph)SPVTVNQTDK ddPTM_A459_Selumetinib_30min_R2 2 SSPVTVNQTDK 11 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;A0A2R8YFX5;H0YHA8 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.81)S(0.19)PVTVNQTDK;S(0.912)S(0.088)PVTVNQTDK 132.5 0.0019993 7799000.0 57026.0 50545.0 52708.0 54037.0 55680.0 48015.0 56327.0 48762.0 52292.0 44508.0 True False 53856.72321316513 54421.63897220905 49316.82466413128 46677.06738097561 48684.98061448434 54628.63041322682 58946.31710983307 48903.88934701631 62751.86116055727 43222.93839432819 1.2460217933779425 1.2590916072321077 1.1409873205335515 1.079914256525898 1.12636906288798 1.2638805329439453 1.3637739427166788 1.131433705428819 1.4518184901744606 1.0 15.3995095327933 -6.776730045604231 24.649424765502317 1.2579955087358525 1.1687302967174058 0.06916217776122313 0.1248848335666878 476.45716104230377 768070.0320733992 0.042302475624163484 0.03744594098849429 1.6721296753876673e-07 6.776730045604231 -0.08926521201844673 S(ph)SPVVNDGVVR ddPTM_A459_Selumetinib_30min_R1 1 SSPVVNDGVVR 11 0 H0YAM1;H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0YAM1 GRSF1 G-rich sequence factor 1 1 S(0.877)S(0.123)PVVNDGVVR 97.957 0.018725 6755500.0 2062.0 2420.0 2096.7 2102.7 1884.8 2017.3 1629.6 1664.2 1078.0 1307.7 True False 2110.040588046447 2136.6652749725217 1811.9796563486982 1735.5029175674624 1714.3201727884673 1997.0077935618508 1506.6779600015125 1620.0600099165506 1829.2872659951393 1475.5560330766777 1.4299969236998795 1.4480407568917373 1.2279978636734956 1.1761687653086073 1.1618129941253015 1.3533933980113892 1.0210916605179285 1.0979318803221372 1.2397274146078325 1.0 10.52704299167866 -1.522878745280382 0.27124490788105293 1.0758755866319083 3.926796209101357 0.5955911751032077 0.09482164780742183 36.51719896168343 0.510620699632177 0.11126688384436605 48.81129949843902 0.02999999999999693 1.522878745280382 2.8509206224694488 S(ph)SPYGTLKPEEMSGPGLAEPK ddPTM_A459_Selumetinib_30min_R1 2 SSPYGTLKPEEMSGPGLAEPK 21 1 Q5JSZ5;A0A494C0D3;H0Y412;A0A494C065;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 S(0.334)S(0.334)PY(0.255)GT(0.076)LKPEEMS(0.002)GPGLAEPK;S(0.469)S(0.469)PY(0.037)GT(0.025)LKPEEMSGPGLAEPK 73.127 0.0022414 42404000.0 2713.59 2687.8 3187.5 3289.7 2539.6000000000004 3027.52 2680.0 2943.1 1705.32 2933.3 True False 2776.811367273013 2373.1111264756787 2754.6550076842045 2715.2156503170586 2309.8936284027973 2997.0658975682204 2477.8454423196226 2865.0394274638893 2893.803488355129 3309.81762776158 0.8389620455163755 0.7169915062905163 0.8322679124611375 0.8203520422221423 0.6978915119154078 0.9055078661826838 0.748635037029331 0.8656185172962255 0.8743090447289086 1.0 11.692536010826757 -8.661064626230228 0.7623588126709844 1.0012481957445185 0.7894741815437699 0.5219212388147502 0.05982219146808483 0.6409745304435156 0.8017574467563506 0.05536755686289382 0.020366250307737824 2.182405129657867e-09 8.661064626230228 -0.2117740142007486 S(ph)SPYGTLKPEEMSGPGLAEPK ddPTM_A459_Selumetinib_30min_R2 2 SSPYGTLKPEEMSGPGLAEPK 21 1 Q5JSZ5;A0A494C0D3;H0Y412;A0A494C065;Q5JSZ5-5 Q5JSZ5;Q5JSZ5-5 PRRC2B Protein PRRC2B 1 S(0.491)S(0.491)PY(0.018)GTLKPEEMSGPGLAEPK;S(0.449)S(0.449)PY(0.08)GT(0.021)LKPEEMSGPGLAEPK 130.16 2.9553000000000007e-05 11121200.0 27012.0 24163.2 26165.0 25430.0 24194.9 19962.1 24307.0 20941.6 18758.7 25761.0 True False 25510.781177603498 26016.439743066214 24481.572386298016 21966.39013080315 21155.320356849617 22711.698077098314 25437.323663406765 21002.536588931493 22510.96416187077 25017.212994883797 1.0197291434030098 1.0399415693661307 0.9785891174730245 0.8780510497030759 0.8456305808794943 0.9078428553069849 1.0167928645212752 0.8395234350535635 0.8998190232650786 1.0 14.610633456726353 -5.5573083219107575 4.1140515711152315 0.9075094712581082 1.0269998585068167 0.42704935168781866 0.05497637842325663 0.18726345535014918 6.9994237356812015 0.015348324591843477 0.029248613199265586 2.7713519196155588e-06 5.5573083219107575 0.11949038724870853 S(ph)SQGSSSSTQSAPSETASASK ddPTM_A459_Selumetinib_30min_R2 1 SSQGSSSSTQSAPSETASASK 21 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 S(0.646)S(0.13)QGS(0.215)S(0.009)SSTQSAPSETASASK 227.7 9.0526e-25 1953100.0 5438.6 4471.1 6000.6 7022.6 7512.0 6302.5 7472.9 6503.6 6972.5 6706.5 True False 5136.34438444078 4814.018993147571 5614.527928959289 6066.109765339295 6568.275401867929 7170.612166601311 7820.404657270428 6522.524399271058 8367.19482792751 6512.865919420368 0.7886458047792736 0.7391552432843587 0.8620671757140934 0.9314040608837172 1.0085076958643258 1.1009918299131023 1.2007624222619384 1.0014829845985145 1.2847178080202475 1.0 12.66907681083293 -6.056401893028228 1.0306648703684407 1.1283649593775211 0.7538914611941562 0.7480492269322856 0.08208151735198616 0.2536034267894066 0.5525267375836889 0.032476697804382754 0.06370655021236495 8.782094518988595e-07 6.056401893028228 -0.37447349818336495 S(ph)SQSSSQQFSGIGR ddPTM_A459_Selumetinib_30min_R2 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 S(0.944)S(0.02)QS(0.032)S(0.004)SQQFSGIGR 172.09 0.00012899 6164600.0 15686.0 14734.0 19001.0 16445.0 18440.0 11791.0 11717.0 11538.0 13633.0 16202.0 True False 14814.234916033185 15864.0504227229 17778.496346724583 14205.162630792678 16123.402344308392 13415.103221958929 12261.863716795042 11571.573669781277 16359.980937846656 15734.206162148499 0.9415304949843308 1.008252355361071 1.1299264903172552 0.9028204209606574 1.0247356732299704 0.8526075661974867 0.7793125112529153 0.7354405777152461 1.0397716141030091 1.0 13.941616771733788 -6.765166723449354 24.75634965888336 0.85850934207674 1.003488651662925 0.24157645604132227 0.10235334766449355 103.62162788001778 688230.3805011837 0.03496275940108404 0.032025270599299674 1.717249017411487e-07 6.765166723449354 0.14497930958618488 S(ph)SRGQEEISGALPVASPASSR ddPTM_A459_Selumetinib_30min_R1 3 SSRGQEEISGALPVASPASSR 21 1 H0Y9D5;H0Y8S9;Q9UBK8;Q9UBK8-1 H0Y9D5 MTRR Methionine synthase reductase 1 S(0.5)S(0.5)RGQEEISGALPVASPASSR;S(0.5)S(0.5)RGQEEISGALPVASPASSR;S(0.5)S(0.5)RGQEEISGALPVASPASSR 160.05 5.1357e-07 20545700.0 2464.37 2698.66 3259.17 3673.3999999999996 2979.51 2512.62 3114.79 2376.5299999999997 1429.98 2093.1099999999997 True False 2521.7850261707154 2382.6996326270028 2816.592615339335 3031.9096482581044 2710.0138465752157 2487.3453240764266 2879.8388825681827 2313.496704342615 2426.571618393069 2361.7810571179334 1.0677471641880445 1.0088571188451296 1.1925714311454447 1.283738659483502 1.1474449921629182 1.0531650749674986 1.2193504871626129 0.9795559573018849 1.027432924436357 1.0 11.205659514236022 -7.777158769288863 24.99972819554998 1.002620773200178 1.1386308526220137 0.3917570257444888 0.07802810521209748 284.47908848458576 452421.87019898713 0.04602547313496209 0.02222892999155537 1.670479808997732e-08 7.777158769288863 0.13601007942183574 S(ph)SRGQEEISGALPVASPASSR ddPTM_A459_Selumetinib_30min_R2 2 SSRGQEEISGALPVASPASSR 21 1 H0Y9D5;H0Y8S9;Q9UBK8;Q9UBK8-1 H0Y9D5 MTRR Methionine synthase reductase 1 S(0.5)S(0.5)RGQEEIS(0.001)GALPVASPASSR;S(0.5)S(0.5)RGQEEISGALPVASPASSR 79.332 0.0012173 19145800.0 32642.0 39480.0 46803.0 47227.0 46123.0 39734.0 37631.0 33229.0 30273.0 49366.0 True False 30827.8883162792 42507.98905179174 43791.74593525342 40794.60112888087 40328.61639514839 45206.997830660344 39380.916064411904 33325.69088864293 36328.44589829324 47940.675311728344 0.6430424293321829 0.88667897928823 0.9134570101589721 0.8509392256913153 0.8412191971205354 0.9429779104425918 0.8214510081124711 0.6951443773360872 0.7577791856721248 1.0 15.548962611065063 -9.866892551441989 11.052209024308265 0.9999997378985526 0.8238216375830166 0.2688981447836203 0.08990438600343521 0.0 0.0 0.09097287105127312 0.022064162141770254 1.3586495477426898e-10 9.866892551441989 -0.17617810031553593 S(ph)SS(ph)PVTELASR ddPTM_A459_Selumetinib_30min_R1 1 SSSPVTELASR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.993)S(0.102)S(0.904)PVTELASR 160.86 0.011005 5601300.0 2954.3 3579.2 2320.9 2332.9 3001.5 2321.5 3166.2 3062.7 1823.1 3064.1 True False 3023.1294419328865 3160.1456000750627 2005.7345277911438 1925.5028089566433 2730.014854957865 2298.14781775335 2927.370984877756 2981.4672469483353 3093.667546044284 3457.40708186147 0.8743921008877068 0.9140218450566829 0.5801268061009626 0.5569210577077754 0.7896133693021833 0.6647026986813557 0.846695490454557 0.8623419737264816 0.8947941254226423 1.0 11.755474763994766 -7.94034302541559 1.1108799281172483 0.9751344353012927 0.7268410629623501 0.38370400194286947 0.11085718399269115 0.5743991771383591 1.2867908737711364 0.10978403971926873 0.03995717098466429 1.1472471159070481e-08 7.94034302541559 -0.24829337233894266 S(ph)SSCGSGGGGISPK ddPTM_A459_Selumetinib_30min_R1 1 SSSCGSGGGGISPK 14 0 F5GWH4;Q96EP1-2;Q96EP1-4;Q96EP1;F5H375 F5GWH4 CHFR E3 ubiquitin-protein ligase CHFR 1 S(0.333)S(0.333)S(0.333)CGSGGGGISPK 173.33 1.1369e-09 0.0 1957.9 2270.5 2351.1 2732.2 2121.6 2037.8 2050.8 2095.6 1290.7 1757.4 True False 2003.5152605897852 2004.6688044731877 2031.833533667871 2255.072559745955 1929.7016545989036 2017.30158217436 1896.106504891447 2040.0178805318615 2190.223631001788 1982.9794085256194 1.0103560591581908 1.010937781731024 1.0246367284159423 1.1372143099673646 0.9731324724313054 1.0173083863106072 0.9561907182390946 1.0287640263741575 1.1045115353115331 1.0 10.95345398120403 S(ph)SSDPPAVHPPLPPLR ddPTM_A459_Selumetinib_30min_R1 3 SSSDPPAVHPPLPPLR 16 0 O43150 O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 1 S(0.464)S(0.071)S(0.464)DPPAVHPPLPPLR;S(0.587)S(0.078)S(0.335)DPPAVHPPLPPLR;S(0.464)S(0.071)S(0.464)DPPAVHPPLPPLR 127.2 0.00069963 16544400.0 8794.3 9668.7 10226.199999999999 11157.3 10102.4 9632.699999999999 9056.5 8936.099999999999 5366.9 8589.7 True False 8999.190079271026 8536.68410914332 8837.538208495755 9208.88700346005 9188.63970372358 9535.803783791818 8373.36091357002 8699.08559945637 9107.237317132936 9692.271665763354 0.9284913165465073 0.8807722692398324 0.9118128869327063 0.9501267939062423 0.9480377790256554 0.9838564283619663 0.8639214007122594 0.8975280408394577 0.9396390888735638 1.0 13.242619127478253 S(ph)SSDPPAVHPPLPPLR ddPTM_A459_Selumetinib_30min_R2 2 SSSDPPAVHPPLPPLR 16 0 O43150 O43150 ASAP2 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 1 S(0.793)S(0.104)S(0.104)DPPAVHPPLPPLR;S(0.753)S(0.123)S(0.123)DPPAVHPPLPPLR 123.4 0.00090608 20672000.0 69342.0 61636.0 69754.0 70918.0 79702.0 48073.0 55255.0 59927.0 48035.0 68048.0 True False 65488.24923801944 66363.2830090233 65266.10358241287 61258.84605962634 69689.12221507958 54694.61938675525 57824.466985705374 60101.377648551075 57643.34221003916 66083.27743006285 0.9909957826672089 1.0042371624085502 0.9876341809996514 0.9269946716014154 1.054565162704481 0.8276620275778479 0.875024200288826 0.9094793718752444 0.8722833438617534 1.0 16.011997619194894 -6.762414622644204 24.999997343314668 0.8898656543464586 0.9895637135532616 0.47356650324549265 0.0502734070637092 22.028234795495056 564673.5168321227 0.01639779975296653 0.015294111212967565 1.7281656848345168e-07 6.762414622644204 0.09969805920680297 S(ph)SSEAKPTSLGLAGGHK ddPTM_A459_Selumetinib_30min_R2 2 SSSEAKPTSLGLAGGHK 17 1 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 S(0.324)S(0.324)S(0.324)EAKPT(0.006)S(0.021)LGLAGGHK;S(0.499)S(0.391)S(0.109)EAKPT(0.001)SLGLAGGHK 85.177 0.0065271 15013500.0 67738.0 67649.0 61940.0 74918.0 66877.0 51825.0 73045.0 129108.0 126718.0 182749.0 True False 63973.39313669869 72837.46077418105 57954.84783517291 64714.03915924148 58475.31337203435 58963.42332949041 76441.7372359217 129483.68290502013 152065.140796747 177472.5615310751 0.3604692048437982 0.41041533488785165 0.32655666507087144 0.364642503612651 0.3294893186167003 0.33223965902563496 0.43072425718347956 0.7295983209345169 0.8568374710144739 1.0 17.43723646579795 -7.947898121213667 1.5807334033219345 0.9666812277559346 0.35052396402946606 0.9790487828958497 0.03443528395978888 0.051463906261847436 0.23261163451365918 0.030639285696457044 0.010513286425761272 1.127461910328593e-08 7.947898121213667 -0.6161572637264685 down S(ph)SSEDAESLAPR ddPTM_A459_Selumetinib_30min_R1 2 SSSEDAESLAPR 12 0 Q4G0J3;Q4G0J3-3;H0YA82 Q4G0J3 LARP7 La-related protein 7 1 S(0.873)S(0.009)S(0.118)EDAESLAPR;S(0.652)S(0.085)S(0.263)EDAESLAPR 208.08 8.5503e-06 83032200.0 3262.7 5518.4 4551.1 4485.7 3796.5 4017.7 4175.3 4428.3 2572.6000000000004 3381.0 True False 3338.7145618909512 4872.303162565438 3933.0856174028518 3702.3567020175815 3453.107245326516 3977.2855857797254 3860.3537594466843 4310.847098854381 4365.5143047301435 3814.984283728872 0.8751581431490456 1.2771489474664657 1.0309572267906026 0.9704775764891997 0.9051432426744764 1.042543111577963 1.0118924410544274 1.1299776822778518 1.144307284134646 1.0 11.897461398384246 -7.753911398725056 24.90669257265951 1.1028568660444296 1.021778152147913 0.0881948763502397 0.10797847209542853 385.4608328758118 1275326.8667378253 0.052485613485274585 0.02954094819767762 1.7623355472945908e-08 7.753911398725056 -0.08107871389651655 S(ph)SSEDAESLAPR ddPTM_A459_Selumetinib_30min_R2 2 SSSEDAESLAPR 12 0 Q4G0J3;Q4G0J3-3;H0YA82 Q4G0J3 LARP7 La-related protein 7 1 S(0.818)S(0.115)S(0.04)EDAES(0.027)LAPR;S(0.755)S(0.122)S(0.122)EDAESLAPR 151.66 0.00051649 260330000.0 175123.0 166403.0 211802.0 197573.0 207040.0 170314.0 181394.0 166479.0 160245.0 191561.0 True False 165390.36473291324 179165.57503002332 198174.8899125818 170663.21656756473 181029.7842389161 193773.2075434411 189829.18042539223 166963.4263279177 192298.4776193971 186030.13619474956 0.8890514629294839 0.963099735853873 1.0652837973795721 0.9173955363280621 0.9731207423801553 1.0416226720416177 1.0204216602124376 0.8975074132780752 1.0336953009489032 1.0 17.505176825968732 -4.82571577703544 4.025501730881901 0.9904907658814479 0.8845413227327944 0.27866297008942786 0.050472904217336 0.28499758726177193 8.057182215939688 0.012508543537604845 0.0783413823871339 1.4937716849927154e-05 4.82571577703544 -0.10594944314865351 S(ph)SSERSTPPYLFPEYPEASK ddPTM_A459_Selumetinib_30min_R2 2 SSSERSTPPYLFPEYPEASK 20 1 Q8TE76-2;Q8TE76-3;Q8TE76 Q8TE76-2 MORC4 MORC family CW-type zinc finger protein 4 1 S(0.2)S(0.2)S(0.2)ERS(0.2)T(0.2)PPY(0.002)LFPEYPEASK;S(0.2)S(0.2)S(0.2)ERS(0.2)T(0.2)PPY(0.001)LFPEYPEASK 75.017 0.0034344 9075300.0 86920.0 124681.0 120342.0 121143.0 109067.0 56293.0 41435.0 46420.0 28453.2 104860.0 True False 82089.33436832868 134243.63178739708 112599.32673846264 104643.11441666851 95365.02838864866 64046.84977302463 43361.8096018949 46555.07451475533 34144.63504883288 101832.41934100029 0.8061218116937879 1.3182799019815414 1.1057316271884676 1.0276011813708974 0.9364898625191781 0.6289436133158604 0.4258153727713346 0.4571734111399147 0.3353022079785292 1.0 16.635837404972847 -6.715598017995868 2.1330182623771594 0.5069231327208302 1.0853196683757496 0.5710430476672028 0.20452128485593382 0.19905282716074332 1.8608596604396048 0.07569461123992782 0.0718363040152939 1.9248725623672453e-07 6.715598017995868 0.5783965356549193 S(ph)SSESLIFSGNQGR ddPTM_A459_Selumetinib_30min_R1 2 SSSESLIFSGNQGR 14 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 S(0.923)S(0.076)S(0.001)ESLIFSGNQGR;S(0.868)S(0.13)S(0.002)ESLIFSGNQGR 236.42 2.5358e-19 48924000.0 5006.6 6816.700000000001 6475.9 7378.7 6631.4 5957.7 6532.4 5522.8 3600.8 5171.0 True False 5123.2440388522455 6018.597595002149 5596.5083495724375 6090.148560353374 6031.591040868759 5897.770947158794 6039.655808734586 5376.317403417335 6110.294607973374 5834.748219805382 0.878057432103408 1.0315093930827575 0.959168783080602 1.0437722984654358 1.0337363008047573 1.0108012762469318 1.035118497184449 0.9214309171333296 1.047225069152544 1.0 12.510454686974258 -4.7550456548470885 24.999252387865965 1.0078848671913143 0.8780572157795264 0.5122616907366961 0.03836908674710866 174.14951348629103 680855.2708583963 0.009190878350514712 0.08402122193219305 1.7577388234104202e-05 4.7550456548470885 -0.12982765141178787 S(ph)SSESLIFSGNQGR ddPTM_A459_Selumetinib_30min_R2 4 SSSESLIFSGNQGR 14 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 S(0.849)S(0.136)S(0.013)ES(0.002)LIFSGNQGR;S(0.681)S(0.317)S(0.001)ESLIFSGNQGR;S(0.991)S(0.009)SESLIFSGNQGR;S(0.931)S(0.068)S(0.001)ESLIFSGNQGR 284.91 4.0163e-55 55514200.0 115420.0 127763.0 107267.0 114569.0 110870.0 84716.0 129071.0 102741.0 104423.0 81132.0 True False 109005.41846286826 137562.01127720578 100365.55800347924 98964.50455745103 96941.51940962428 96384.86002471982 135073.05724933435 103039.95930031194 125310.51782239857 78789.5083537485 1.3835016963611018 1.7459432626433073 1.2738441970326653 1.2560619633913819 1.2303861444899113 1.223320998424966 1.7143533456622728 1.3077878191304857 1.590446754151332 1.0 16.265715912102323 -5.281351444368654 24.663291000577722 1.340018350046173 1.5647225318365967 0.17632818029991337 0.2054846788632866 1065.72114590968 1320012.245573547 0.05280682340604739 0.11017495109442185 5.2317689450370746e-06 5.281351444368654 0.22470418179042362 S(ph)SSFHDDHFLSR ddPTM_A459_Selumetinib_30min_R1 1 SSSFHDDHFLSR 12 0 J3QQV3;Q8N8E3 J3QQV3 CEP112 Centrosomal protein of 112 kDa 1 S(0.333)S(0.333)S(0.333)FHDDHFLSR 88.78 0.017648 5805800.0 2408.2 2410.8 2354.7 2497.1 3416.1 2199.9 2756.5 2477.0 1047.0 1624.2 True False 2464.3063744585115 2128.542415249486 2034.944673441255 2061.0283613723836 3107.1143581614388 2177.7710033493854 2548.574985729118 2411.3019135700633 1776.6825301455576 1832.6818910477475 1.3446449089152417 1.1614358310882826 1.11036437004235 1.12459689345983 1.695392077227923 1.18829733298906 1.3906259445124396 1.3157231079483835 0.9694440365369819 1.0 10.839740675539627 -8.262787748828266 24.675917924195574 0.98472196932488 1.2887984660032368 0.36197727664111035 0.16282518401681054 115.2329016970877 2108681.5231859796 0.13536409898294607 0.04233440732444357 5.460246525459651e-09 8.262787748828266 0.3040764966783568 S(ph)SSLDGEHHDGYHR ddPTM_A459_Selumetinib_30min_R2 3 SSSLDGEHHDGYHR 14 0 Q9C0J8 Q9C0J8 WDR33 pre-mRNA 3 end processing protein WDR33 1 S(0.461)S(0.461)S(0.077)LDGEHHDGYHR;S(0.432)S(0.432)S(0.135)LDGEHHDGYHR;S(0.449)S(0.449)S(0.101)LDGEHHDGYHR 81.44800000000002 0.016624 15130100.0 8827.4 12319.849999999999 18957.5 24879.7 18885.2 20730.5 22695.8 20065.8 25295.800000000003 20704.100000000002 True False 8336.808446882022 13264.742880438618 17737.795089365347 21491.041940123603 16512.6723401699 23585.93820225762 23751.199670874525 20124.188155927994 30355.66682370581 20106.3188372879 0.414636240196346 0.6597300573906482 0.8822000303939257 1.068870045981151 0.8212678051014761 1.1730609861073444 1.181280365793616 1.0008887414342078 1.5097575577788074 1.0 14.295361349739562 -4.842250001162481 0.5744490797400806 1.1740727664250934 5.783474077860528e-13 0.6950684659130861 0.15845076890871573 2.0629095350400286 0.5435629722654635 0.0839112538332196 1.605838260974974 1.4379705737079086e-05 4.842250001162481 -1.174072766424515 S(ph)SSLESLQTAVAEVR ddPTM_A459_Selumetinib_30min_R2 1 SSSLESLQTAVAEVR 15 0 A0A087WZG6;A0A087X1S9;Q8TEW8-5;Q8TEW8-2;Q8TEW8;R4GN62 A0A087WZG6 PARD3B Partitioning defective 3 homolog B 1 S(0.976)S(0.012)S(0.012)LESLQTAVAEVR 300.56 1.3449999999999992e-80 7672900.0 22274.0 18563.0 28083.0 33296.0 29894.0 22732.0 25238.0 25883.0 19617.0 21759.0 True False 21036.10024988674 19986.722410547387 26276.170354458507 28761.02736119629 26138.4484642492 25863.12665944959 26411.617008148274 25958.315244838683 23540.94814477648 21130.76113332853 0.995520233140467 0.9458590859286793 1.2435032599471474 1.3610975572400423 1.236985657985707 1.2239562264823924 1.2499131877692045 1.2284609665051716 1.1140605866603868 1.0 14.367057113859772 -5.262181547021927 24.995495388937893 1.22408378769218 0.9706896409114173 0.510867782543482 0.09140812384033642 43.86697296102215 1477464.6285704658 0.02295315689371338 0.052761544624428405 5.467873429849704e-06 5.262181547021927 -0.25339414678076266 S(ph)SSLESLQTAVAEVTLNGDIPFHRPRPR ddPTM_A459_Selumetinib_30min_R1 1 SSSLESLQTAVAEVTLNGDIPFHRPRPR 28 2 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.328)S(0.328)S(0.328)LES(0.015)LQTAVAEVTLNGDIPFHRPRPR 89.29899999999998 7.510499999999999e-06 11677000.0 866.65 842.23 1148.1 1113.4 1270.4 707.25 883.17 936.43 488.98 649.43 True False 886.8412587926539 743.6213200578961 992.1943260618776 918.9655911064887 1155.492544307337 700.1357071316203 816.5517758557532 911.5928344466745 829.7633463138244 732.7906664838927 1.2102245557355873 1.0147800102667404 1.3539942188710818 1.2540629038247832 1.5768385122202369 0.9554375337380335 1.1143042797935279 1.2440016994494731 1.1323333992437843 1.0 9.517257317795886 S(ph)SSLSDLTHR ddPTM_A459_Selumetinib_30min_R2 2 SSSLSDLTHR 10 0 Q5T9C2-3;Q5T9C2-2;Q5T9C2 Q5T9C2-3 FAM102A Protein FAM102A 1 S(0.457)S(0.457)S(0.087)LSDLTHR;S(0.469)S(0.469)S(0.061)LSDLTHR 131.17 0.001756 7906900.0 44073.0 33307.0 57250.0 62853.0 67452.0 48639.0 38100.0 48296.0 55285.0 53445.0 True False 41623.599098197796 35861.53980111521 53566.59732908698 54292.31297252734 58978.076731469104 55338.58074911883 39871.72549371776 48436.533364166775 66343.54479196445 51901.90398321359 0.8019667084209461 0.6909484440631263 1.0320738396497322 1.046056287069678 1.136337440540604 1.0662148495942798 0.7682131566235663 0.9332323026113338 1.278248767394384 1.0 15.663499843310952 -5.267735193182261 24.70401551467908 1.0261137231304946 0.7464575690011539 0.44985317616186504 0.12639098122536963 365.8247125002702 1435458.2814592968 0.03448676973266275 0.07478143995344996 5.39839684157619e-06 5.267735193182261 -0.27965615412934075 S(ph)SSMELHR ddPTM_A459_Selumetinib_30min_R1 2 SSSMELHR 8 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.476)S(0.476)S(0.049)MELHR;S(0.456)S(0.456)S(0.087)MELHR 103.55 0.010138 5622900.0 5464.5 7654.700000000001 4505.4 4446.5 6775.0 5100.7 6742.7 5997.3 2795.8 6359.4 True False 5591.812217933949 6758.484165426519 3893.5914263907207 3670.002246142446 6162.202446223399 5049.391589065054 6234.092710421082 5838.2321220241165 4744.268402847131 7175.690935801653 0.7792716085408218 0.9418583138393594 0.5426085740349319 0.5114493195117581 0.8587608498407229 0.7036801938991185 0.8687794340914744 0.8136125390929873 0.661158409035786 1.0 12.808902037936472 S(ph)SSMSSIDLVSASDDVHR ddPTM_A459_Selumetinib_30min_R2 1 SSSMSSIDLVSASDDVHR 18 0 A0A2U3TZL3;Q9Y5P4;Q9Y5P4-3;A0A0A0MRE4;A0A2R8YFA1 A0A2U3TZL3 COL4A3BP Collagen type IV alpha-3-binding protein 1 S(0.332)S(0.332)S(0.332)MS(0.003)SIDLVSASDDVHR 179.78 9.8664e-10 6616600.0 16999.0 15588.0 21148.0 20495.0 21924.0 16617.0 13151.0 15856.0 15157.0 20979.0 True False 16054.263632388635 16783.549476680084 19787.360704201434 17703.545644152986 19169.711116953207 18905.840915892746 13762.547558212127 15902.138334897889 18188.82352196449 20373.28176001193 0.7880057725358447 0.8238019615289636 0.9712407130715422 0.8689589557879172 0.9409240662728645 0.9279722893245685 0.6755194239361498 0.7805388705765671 0.8927782836472113 1.0 14.314390770140312 -8.541261827726737 21.925698663457677 1.0000000043719435 0.8503943939173451 0.2363908306264214 0.08320034498156911 1140.081979307332 1359788.880872233 0.08695286665627566 0.022451133598941082 2.875664209805715e-09 8.541261827726737 -0.14960561045459841 S(ph)SSMSYVDGFIGTWPK ddPTM_A459_Selumetinib_30min_R2 1 SSSMSYVDGFIGTWPK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.46)S(0.079)S(0.46)MS(0.001)YVDGFIGTWPK 140.93 0.0015108 6180100.0 18005.0 17099.0 21222.0 20860.0 21732.0 13822.0 15520.0 18137.0 12901.0 16508.0 True False 17004.354179725717 18410.438318049313 19856.599624766528 18018.832014492862 19001.831873454987 15725.85503637658 16241.71075229658 18189.775667258025 15481.560484057783 16031.371147065009 1.0606924400748365 1.1484007293674228 1.2386089400969196 1.1239732303117262 1.185290496935055 0.9809426088457592 1.0131205000060197 1.1346363015610286 0.9657040774638991 1.0 13.968610202576167 -6.757267168749596 24.99987902463125 1.0269354498980359 1.1545489215144262 0.5461200050590583 0.060144269443443116 88.18488769238436 528403.5172668752 0.020329522600760378 0.019636720822640535 1.7487705511157454e-07 6.757267168749596 0.12761347161639036 S(ph)SSNVNGGPELDR ddPTM_A459_Selumetinib_30min_R2 1 SSSNVNGGPELDR 13 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 S(0.476)S(0.047)S(0.476)NVNGGPELDR 210.02 7.6624e-06 26644000.0 47217.0 37511.0 47866.0 55980.0 46053.0 48316.0 41510.0 39182.0 33136.0 41779.0 True False 44592.86816462701 40387.97308312464 44786.35367256031 48355.427429113646 40267.41042095634 54971.090431020864 43440.29725050459 39296.013133070715 39764.12589719701 40572.73171512171 1.0990846876599876 0.9954462363221108 1.1038535434839396 1.191820845799527 0.9924747168539413 1.3548777246993404 1.0706771620781483 0.968532594970056 0.980070215049796 1.0 15.30822282035303 -7.621375213055983 5.200127751762204 0.9828534704339473 1.1208408747282415 0.2930868936609501 0.09678719986895977 0.2753221365466726 11.814037329260081 0.047512703510177466 0.026748771227255785 2.391248920310252e-08 7.621375213055983 0.13798740429429412 S(ph)SSPAELDLKDDLQQTQGK ddPTM_A459_Selumetinib_30min_R1 1 SSSPAELDLKDDLQQTQGK 19 1 H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 H7C1F9 RALGAPA2 Ral GTPase-activating protein subunit alpha-2 1 S(0.445)S(0.445)S(0.11)PAELDLKDDLQQTQGK 96.467 0.00089791 5611600.0 1066.0 1340.9 1490.0 1244.6 1167.9 1426.6 1143.3 1050.3 718.65 1062.4 True False 1090.8357259250783 1183.9068046325026 1287.666183984146 1027.253974035508 1062.263651209492 1412.2496992491626 1057.0599605238892 1022.4426321447861 1219.4965618807116 1198.769388652337 0.9099629472115581 0.9876017988442772 1.0741567111850823 0.8569237617840345 0.8861284424385365 1.1780828845127762 0.8817875819403778 0.8529101942569801 1.0172903758008671 1.0 10.22733843395043 -8.314037753254615 0.005928238887947656 1.0458575811200264 0.8809766513817661 0.001306275332619733 0.10103077037500083 270502.797995663 1307.1607026230322 18265.245713858752 18080.680112987022 4.852463158269239e-09 8.314037753254615 -0.1648809297382603 S(ph)SSPAELDLKDDLQQTQGK ddPTM_A459_Selumetinib_30min_R2 3 SSSPAELDLKDDLQQTQGK 19 1 H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 H7C1F9 RALGAPA2 Ral GTPase-activating protein subunit alpha-2 1 S(0.353)S(0.353)S(0.294)PAELDLKDDLQQTQGK;S(0.429)S(0.141)S(0.429)PAELDLKDDLQQT(0.001)QGK;S(0.459)S(0.459)S(0.082)PAELDLKDDLQQTQGK 126.29 0.00020439 19352400.0 85081.0 59073.0 75858.0 72635.0 75993.0 54758.0 71046.0 75567.0 55155.0 67528.0 True False 80352.53862622853 63603.70915036711 70977.3788679454 62741.98769763607 66446.07995396036 62300.417456367315 74349.77977497826 75786.88745920961 66187.54115946114 65578.29118118531 1.225291741808637 0.9698896998495636 1.0823304113222931 0.9567493535976279 1.0132328665042132 0.9500158716279812 1.1337559798494647 1.1556703612452957 1.009290421682269 1.0 16.00093068846936 -10.18072048566104 14.381198357219313 1.0000277661374388 1.0514801372487792 0.03246432599435822 0.08829262425381543 0.0 0.0 0.08484943137025949 0.020579009871363328 6.595982797752974e-11 10.18072048566104 0.05145237111134038 S(ph)SSPEDPERDEEVLNHVLR ddPTM_A459_Selumetinib_30min_R1 2 SSSPEDPERDEEVLNHVLR 19 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 S(0.333)S(0.333)S(0.333)PEDPERDEEVLNHVLR;S(0.333)S(0.333)S(0.333)PEDPERDEEVLNHVLR 107.41 0.00033466 9388500.0 1508.42 1736.94 1493.58 1467.46 1943.0900000000001 1562.6100000000001 1829.85 1703.92 822.45 1709.01 True False 1543.5632511256165 1533.5782573185004 1290.760039647679 1211.1956586358242 1767.337852580403 1546.8915621363608 1691.822941279312 1658.7265064878081 1395.637580628666 1928.3780806671043 0.8004463785398531 0.7952684552336197 0.6693500888586913 0.6280903474161158 0.9164892871884383 0.8021723424699103 0.8773294813089982 0.8601666463217562 0.7237364885136313 1.0 10.913172220892111 -6.270786235959008 24.978326242987585 0.8539675593275717 0.7245774518911196 0.4042256962590409 0.08280982548443874 733.9547624872295 1961400.7255083849 0.025703535301689458 0.029520503964301358 5.360604468439859e-07 6.270786235959008 -0.12939010743645218 S(ph)SSPEDPERDEEVLNHVLR ddPTM_A459_Selumetinib_30min_R2 2 SSSPEDPERDEEVLNHVLR 19 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 S(0.333)S(0.333)S(0.333)PEDPERDEEVLNHVLR;S(0.333)S(0.333)S(0.333)PEDPERDEEVLNHVLR 86.74799999999998 0.0015019 8442600.0 22059.1 17152.4 21678.4 22054.1 21556.6 14706.6 16965.0 20191.0 13975.0 17919.1 True False 20833.14353157386 18467.933926341273 20283.63534565729 19050.293534555472 18848.46718955089 16732.30065677729 17753.90611550976 20249.75246720001 16770.390494125055 17401.729023586908 1.1971881359223497 1.0612700554817969 1.1656103435563299 1.0947356730319178 1.0831376102916568 0.9615309279955887 1.0202380517157519 1.1636632451725224 0.9637197816029595 1.0 14.086943037912345 -6.312958382487006 2.4754515155542656 1.0322172558156413 1.1311169720306344 0.38508728436364803 0.06340417885421847 0.351033804634234 4.230904888576944 0.02097198934368576 0.025680145589598538 4.864538192889224e-07 6.312958382487006 0.09889971621499316 S(ph)SSPELVTHLK ddPTM_A459_Selumetinib_30min_R1 1 SSSPELVTHLK 11 0 E9PNR6;H0YE29;Q07960 E9PNR6 ARHGAP1 Rho GTPase-activating protein 1 1 S(0.392)S(0.392)S(0.216)PELVTHLK 194.06 1.3503e-05 84117000.0 10310.0 11057.0 10395.0 11261.0 10672.0 9395.1 10856.0 9749.6 5217.0 7544.5 True False 10550.20294023223 9762.441299740163 8983.416095647783 9294.477745150138 9706.719484294632 9300.593824068279 10037.123179784261 9491.008936835962 8852.867965395768 8512.9100646532 1.2393180310970457 1.1467807395587546 1.055269705355891 1.0918096954579746 1.1402351734688583 1.0925281429538005 1.1790472474811884 1.1148959480077165 1.0399343935458827 1.0 13.05543667370372 -14.522878745279852 0.0807560997890678 0.6033123658310142 1.2392848217164982 0.4440168143618879 0.049697178419576264 281.39891398947776 1.6008401369903664 19.83771933259984 1.8014374600666971 3.000000000003351e-15 14.522878745279852 0.635972455885484 S(ph)SSPELVTHLK ddPTM_A459_Selumetinib_30min_R2 1 SSSPELVTHLK 11 0 E9PNR6;H0YE29;Q07960 E9PNR6 ARHGAP1 Rho GTPase-activating protein 1 1 S(0.383)S(0.383)S(0.234)PELVTHLK 136.01 0.00095939 20383000.0 87404.0 66615.0 88845.0 93214.0 92412.0 60401.0 63087.0 62759.0 60068.0 71506.0 True False 82546.43558593423 71724.15629901487 83128.80942712192 80518.09239688117 80802.37838623796 68720.68948431345 66020.67050451903 62941.61829968822 72083.27844015049 69441.43598509986 1.1887201699522219 1.0328725966209111 1.1971067165857425 1.15951076262533 1.1636046582270538 0.9896208007429302 0.9507388429969273 0.9063985703462942 1.0380441794956183 1.0 16.083509161248344 -6.80724693421149 5.5507603907142915 0.9674198227446194 1.145439734465437 0.722932121590421 0.05296132434979648 0.10036703593581521 7.087165918214924 0.01850103607218304 0.016583207991127058 1.5586660135415349e-07 6.80724693421149 0.17801991172081766 S(ph)SSPGKPQAVSSLNSSHSR ddPTM_A459_Selumetinib_30min_R2 1 SSSPGKPQAVSSLNSSHSR 19 1 Q9UHB7;Q9UHB7-2;Q9UHB7-3 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 S(0.333)S(0.333)S(0.333)PGKPQAVSSLNSSHSR 85.49600000000002 0.0016203 43166000.0 27322.0 22635.0 43153.0 58698.0 67249.0 37145.0 32022.0 38750.0 37493.0 49874.0 True False 25803.552618631835 24371.031717003716 40376.5829614339 50703.23114030216 58800.579406312165 42261.38658126233 33511.08645038923 38862.75608459218 44992.64764194857 48434.0080317858 0.5327569133179672 0.503180155997202 0.8336411666557917 1.0468518547345316 1.214034968316541 0.8725560468488885 0.6918916648070277 0.8023857133419087 0.9289474373547866 1.0 15.563732773947216 -5.340811568537035 3.848419753637379 0.9276272653128801 0.5139251267225566 0.6031748175316309 0.13339723659256691 0.16982275478937783 4.737764175686838 0.04092262351145318 0.09583376059834152 4.5623482394119245e-06 5.340811568537035 -0.41370213859032345 S(ph)SSPNSPLPMFR ddPTM_A459_Selumetinib_30min_R2 1 SSSPNSPLPMFR 12 0 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 S(0.882)S(0.042)S(0.042)PNS(0.033)PLPMFR 130.15 0.0022076 4932700.0 12197.0 10475.0 14075.0 11895.0 15103.0 10729.0 10580.0 11370.0 9359.0 9023.9 True False 11519.139568459572 11278.398817566336 13169.429823701304 10274.880479980475 13205.626117466903 12206.822361835066 11071.990963872277 11403.08481759517 11231.061512308872 8763.356560092074 1.3144666075687492 1.2869953128379656 1.5027837488291058 1.1724823028166869 1.5069141631877359 1.3929391413130876 1.2634417974379382 1.3012234227150243 1.281593580644044 1.0 13.097267844567277 -9.181015534503189 0.6839703795800874 0.9918951305320172 1.3572951495934475 0.5373917973839127 0.0963890415551334 1.7737421747854873 1.2183051980620745 0.12665641880123835 0.035229729506021684 6.59150317335166e-10 9.181015534503189 0.3654000190614304 S(ph)SSPPILTKPTLK ddPTM_A459_Selumetinib_30min_R2 1 SSSPPILTKPTLK 13 1 A0A3F2YNX6;Q92794;A0A3B3ITI3;A0A3B3IS53 A0A3F2YNX6 KAT6A Histone acetyltransferase KAT6A 1 S(0.35)S(0.35)S(0.299)PPILTKPTLK 69.431 0.035143 25664000.0 93755.0 76233.0 103580.0 111120.0 99466.0 78515.0 89142.0 92527.0 80644.0 84918.0 True False 88544.47243100154 82079.82597227074 96915.77556937694 95985.26430730804 86970.19184267786 89329.72856179338 93287.27963152192 92796.23825133048 96775.0533816258 82466.19669653909 1.0737062696953203 0.9953147987933757 1.175218203963131 1.1639346562873114 1.0546162588619512 1.0832284274065755 1.1312184066739792 1.1252639501831774 1.1735117812907117 1.0 16.33151525221703 -5.25334326583569 24.99831594190348 1.1171155987175954 1.0345105352731323 0.24177046799592772 0.055549022099975684 819.8553640944999 2531445.849761957 0.01387568339755104 0.035443150157511184 5.580289549678636e-06 5.25334326583569 -0.08260506344446306 S(ph)SSPTQYGLTK ddPTM_A459_Selumetinib_30min_R1 1 SSSPTQYGLTK 11 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 S(0.763)S(0.118)S(0.118)PTQYGLTK 206.46 1.7496e-05 155490000.0 11685.0 13216.0 14195.0 15092.0 13027.0 11494.0 12384.0 11560.0 7029.6 9499.8 True False 11957.237764947964 11668.664576048293 12267.396967553665 12456.465511926635 11848.710150103658 11378.380795717 11449.864909584398 11253.39124782799 11928.717778329712 10719.191865888059 1.1154980631515485 1.088576892926207 1.1444330058679606 1.1620713266237117 1.1053734552331405 1.06149614057443 1.0681649375100353 1.049835788800453 1.1128374160640557 1.0 13.38790852274965 -6.64934680558032 3.874814520839368 1.0620639929236249 1.1268245283631722 0.5226217759984468 0.03133089217540383 0.19863902796472152 5.578886214636365 0.010714246572935373 0.010618409585510602 2.2420907885600558e-07 6.64934680558032 0.0647605354395473 S(ph)SSPVGLAK ddPTM_A459_Selumetinib_30min_R2 2 SSSPVGLAK 9 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.771)S(0.115)S(0.114)PVGLAK;S(0.984)S(0.012)S(0.004)PVGLAK 144.77 0.0019179 258309000.0 576180.0 572600.0 602890.0 640460.0 632890.0 428260.0 530730.0 502820.0 389290.0 515480.0 True False 544158.2222312889 616516.5788008091 564100.7137770002 553228.243144876 553380.7000916122 487248.92764278967 555409.9966215441 504283.12295366824 467158.87767140975 500596.75302211364 1.0870190806196678 1.2315632793838251 1.1268565174893999 1.1051374980061794 1.1054420484168959 0.9733361726804202 1.10949580329581 1.0073639509431491 0.9332039707632167 1.0 18.933289407864002 -6.616231405249711 0.630803252864012 0.9820405017225737 1.1702679400826648 0.5751701781721439 0.05473235778433764 0.5856246310192477 0.5146027658590401 0.04113225575217497 0.0522561364710744 2.419739392768983e-07 6.616231405249711 0.18822743836009104 S(ph)SSPVNVK ddPTM_A459_Selumetinib_30min_R2 1 SSSPVNVK 8 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1X7SBS1 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.333)S(0.333)S(0.333)PVNVK 105.2 0.014257 4361000.0 54782.0 47436.0 49723.0 56344.0 61341.0 51533.0 58822.0 52119.0 52209.0 65610.0 True False 51737.4357497214 51074.18866921973 46523.87631430905 48669.85000117864 53634.79518450223 58631.2029800025 61557.33955358181 52270.6576612351 62652.25884134351 63715.66882474765 0.8120049071763991 0.8015954256040412 0.7301795174162689 0.76385998764365 0.8417834446975164 0.9202006988464617 0.9661256122555599 0.8203736792751484 0.9833100710858252 1.0 15.959360580225743 -6.5887701090227715 2.7021679862624994 0.9296140199819953 0.7759694790512006 0.6939295457129349 0.05047796310568365 0.16516715439527513 2.448368435808121 0.017745968843187288 0.018199314094520434 2.5776852769689267e-07 6.5887701090227715 -0.15364454093079472 S(ph)SSQENLLDEVMK ddPTM_A459_Selumetinib_30min_R1 2 SSSQENLLDEVMK 13 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.469)S(0.071)S(0.46)QENLLDEVMK;S(0.333)S(0.333)S(0.333)QENLLDEVMK 296.51 8.517899999999996e-62 78084000.0 9410.599999999999 11742.1 12176.4 13063.9 11226.7 10260.5 11755.6 10405.2 5670.5 9515.5 True False 9629.848670159976 10367.329473245813 10522.911760177556 10782.535104774603 10211.246967234876 10157.28868578861 10868.865627512147 10129.220295147044 9622.424343066266 10736.907113819008 0.8968922398300172 0.9655787614947764 0.9800691808755588 1.0042496400939214 0.9510417533641902 0.9460162575790195 1.0122901793127463 0.9434020605533752 0.896200762571715 1.0 13.390290848275816 -4.761679220461744 7.68530203156809 0.9667406263353401 0.8958726140257135 0.28486198321043 0.03310900111771248 0.13272932291374384 60.71446594039849 0.008343158871825546 0.04907368529158881 1.73109451192827e-05 4.761679220461744 -0.07086801230962658 S(ph)SSQENLLDEVMK ddPTM_A459_Selumetinib_30min_R2 1 SSSQENLLDEVMK 13 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.559)S(0.028)S(0.413)QENLLDEVMK 97.073 0.013666 3435600.0 8492.1 7429.6 7339.1 7737.8 8468.3 5831.0 6205.4 5180.9 5968.8 6395.2 True False 8020.143078569767 7999.426430070721 6866.910296207902 6683.898291550478 7404.43644643746 6634.167321452167 6493.963395766831 5195.975561255834 7162.726782206348 6210.553959274903 1.2913732222859775 1.288037505595503 1.1056840245229318 1.0762161210383943 1.192234460080586 1.0682086275966793 1.0456335197069953 0.8366364088176245 1.153315280597387 1.0 12.600506242102217 -3.502807398780753 0.32513730538217017 0.985648819846924 2.0050000981983622 0.5435687919357182 0.08728741531682972 12.088239819052408 0.5364351182735784 0.08508930811702664 5.7059549699117325 0.00031419017577342424 3.502807398780753 1.0193512783514382 S(ph)SSSELLLTGPGAEEDPLPLIVQDQYVQEAR ddPTM_A459_Selumetinib_30min_R1 1 SSSSELLLTGPGAEEDPLPLIVQDQYVQEAR 31 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 S(0.25)S(0.25)S(0.25)S(0.25)ELLLT(0.001)GPGAEEDPLPLIVQDQYVQEAR 74.196 2.3455e-05 2710600.0 268.27 258.85 229.58 206.66 295.73 318.28 144.25 156.54 144.57 159.37 True False 274.520169037449 228.54372166389976 198.40429699267136 170.5707104886535 268.98127371537225 315.0783921751181 133.3691063636587 152.38805068641804 245.3247310249696 179.82669189525888 1.5265818780525915 1.2709110046745251 1.103308384876663 0.948528322970004 1.495780581183365 1.7521224955783392 0.7416535607591576 0.8474161932266282 1.3642286828468182 1.0 7.490463367506207 -7.283480183757921 24.992434269946813 0.975609327040651 1.323192170761393 0.31535943821436807 0.2587236821050982 1142.564865671921 1295567.96055021 0.11534751120174513 0.07783624751821511 5.20618763356374e-08 7.283480183757921 0.347582843720742 S(ph)SSVGS(ph)SSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R1 1 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.991)S(0.007)S(0.001)VGS(0.806)S(0.144)S(0.042)S(0.008)YPISPAVSR 214.54 5.2771e-11 43240000.0 6179.7 7934.2 7642.6 8470.3 7387.0 7418.0 7559.1 6602.5 3913.5 5536.6 True False 6323.674986397002 7005.260175490491 6604.776897796802 6991.121112223175 6718.847154280775 7343.381655005111 6988.911001133679 6427.3802520574645 6640.923669268992 6247.276541050954 1.012229080118998 1.1213302515838406 1.057224993066452 1.1190670152480697 1.0754841906118806 1.1754532725983287 1.1187132433164169 1.0288291561647778 1.06301099777341 1.0 12.609011678111605 -7.768810915121716 24.998144107028974 1.0344400347013594 1.0995025341033362 0.3258630480275053 0.04360230744014519 210.89387809879184 715164.7475721976 0.02305336351364006 0.011422791575438325 1.7028997623658546e-08 7.768810915121716 0.06506249940197684 S(ph)SSVGS(ph)SSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R2 2 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.99)S(0.007)S(0.003)VGS(0.564)S(0.355)S(0.067)S(0.013)YPISPAVSR;S(0.935)S(0.056)S(0.021)VGS(0.96)S(0.021)S(0.005)S(0.001)YPISPAVSR 198.67 3.7776e-09 42458000.0 212377.0 202661.0 208090.0 220768.0 212934.0 184862.0 162774.0 165368.0 150227.0 210270.0 True False 200573.93655249118 218204.44704217743 194701.71595126126 190699.01755395823 186183.3272658874 210325.06248984582 170343.31353056213 165849.19350185388 180276.59769308942 204198.9587529293 0.9822475970368477 1.0685874618302735 0.9534902486297238 0.9338882956043604 0.9117741265819092 1.0300006609942063 0.8342026549541282 0.8121941194740531 0.8828477813700081 1.0 17.639615984110826 -5.932226879358377 0.6825630749924978 0.8849047252341412 1.0354640034685356 0.273839359348408 0.06700148946727813 1.2126149221699503 1.056043356829764 0.03953374859381209 0.11475570438542712 1.1688885935361195e-06 5.932226879358377 0.1505592782343944 S(ph)SSVGSS(ph)SSYPISPAVSR ddPTM_A459_Selumetinib_30min_R1 1 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.938)S(0.044)S(0.018)VGS(0.349)S(0.54)S(0.094)S(0.017)YPISPAVSR 185.63 3.2263000000000003e-09 42551000.0 7912.3 10662.0 10043.0 10927.0 10364.0 8993.5 10060.0 9268.5 5472.2 7438.9 True False 8096.641195344272 9413.688083370673 8679.215762250193 9018.804575193632 9426.578029912811 8903.033555444652 9301.166100647539 9022.669271669009 9285.923726325229 8393.755276022091 0.9646029612601923 1.121510905882872 1.0340086739297198 1.074465990324626 1.123046564967306 1.0606734724417548 1.10810546588338 1.0749264155274452 1.106289547522518 1.0 13.035100686030285 -4.748707460613347 24.995922761872993 1.0807596137410402 0.9646026876998995 0.45110855383179427 0.03746102869842368 522.8828224745739 1026487.5284125489 0.008568680726557882 0.15202568534569724 1.7835797765897292e-05 4.748707460613347 -0.1161569260411407 S(ph)SSVGSSSSYPIS(ph)PAVSR ddPTM_A459_Selumetinib_30min_R1 1 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.776)S(0.042)S(0.182)VGSSSS(0.006)YPIS(0.994)PAVSR 240.82 8.1378e-24 45515000.0 2554.6 3194.1 3310.2 3953.9 3134.1 2636.7 3120.0 3021.0 1632.0 2371.2 True False 2614.1172096136993 2820.1332871031973 2860.693021627061 3263.4255888952257 2850.6212083702976 2610.1771919320518 2884.655888073589 2940.873266409025 2769.3848034360535 2675.566617443923 0.9770331235897506 1.0540321697530315 1.0691914762937194 1.2197138234640212 1.0654271098260344 0.9755605317073583 1.0781476601129885 1.0991590518566718 1.0350647916521543 1.0 11.385628734909341 -6.524438576489263 24.999857987540075 1.0434494717857994 1.0855172717138255 0.08263172821856013 0.0647379003109348 148.90691640562693 2386542.9300160664 0.02258342405883615 0.022759931236981352 2.989244394447966e-07 6.524438576489263 0.04206779992802612 S(ph)SSVGSSSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R2 4 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(0.576)S(0.049)S(0.375)VGSSSSYPISPAVSR;S(0.329)S(0.329)S(0.329)VGS(0.009)S(0.003)S(0.001)SYPISPAVSR;S(0.442)S(0.442)S(0.114)VGS(0.002)SSSYPISPAVSR;S(0.469)S(0.035)S(0.469)VGS(0.024)S(0.002)SSYPISPAVSR 309.35 2.0574999999999997e-111 1721102000.0 279956.0 262076.0 316028.0 302869.0 348367.0 255415.0 241312.0 277529.0 228477.0 282384.0 True False 264397.1662726628 282176.3864928418 295695.1025452693 261617.71972183356 304602.0230195052 290596.097823479 252533.48615065683 278336.5634426007 274178.7841807662 274230.8401982562 0.9641408897756208 1.0289739341090935 1.0782707821319273 0.954005463180932 1.1107504276298465 1.0596769408334652 0.9208792343271341 1.0149717779421756 0.9998101744593995 1.0 18.065031301203597 -7.22396164628792 24.999157414587643 0.9851628558381065 1.0345207226020736 0.18318249028707656 0.050279531395359574 981.7245432660563 654850.747686105 0.01914574779853079 0.014829844498706944 5.97088014701697e-08 7.22396164628792 0.04935786676396714 S(ph)SSVPSTTSTPTVT(ph)S(ph)AAGLQK ddPTM_A459_Selumetinib_30min_R2 1 SSSVPSTTSTPTVTSAAGLQK 21 0 H0YHI8 H0YHI8 PPP1R12A 3 S(0.247)S(0.247)S(0.247)VPS(0.249)T(0.006)T(0.001)S(0.001)T(0.001)PT(0.033)VT(0.984)S(0.983)AAGLQK 70.335 0.015024 11489000.0 67048.0 60792.0 72097.0 76160.0 78737.0 60190.0 65126.0 63999.0 44852.0 75139.0 True False 63321.740574409865 65454.55092291096 67458.35751327842 65786.87661667206 68845.35414228907 68480.62614958087 68154.48804472071 64185.22649439517 53823.653269588394 72969.5418354322 0.8677831733851232 0.8970119487735067 0.9244728117577724 0.9015662557542273 0.9434806963370499 0.9384823369732106 0.9340128268645176 0.879616684988262 0.7376180789373267 1.0 16.155006774876796 -10.57389059295314 4.482173532707727 1.0000050761230757 0.8967875883331514 0.24095101532844576 0.05706557905598246 83192596.12830248 3.5408920659149046 4942.989100604695 0.014217247444499679 2.6675305816139786e-11 10.57389059295314 -0.10321748778992423 S(ph)STDSLPGPISR ddPTM_A459_Selumetinib_30min_R1 1 SSTDSLPGPISR 12 0 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 S(0.441)S(0.441)T(0.118)DSLPGPISR 116.71 0.004944 9434100.0 2264.6 2459.1 2444.1 2530.4 3069.4 2141.3 2719.1 2291.4 1113.8 1829.9 True False 2317.3607738554697 2171.1874287954265 2112.2046444803022 2088.5131414907996 2791.773311946583 2119.7604661448427 2513.99609784003 2230.624628483827 1890.037251266592 2064.785489735422 1.1223251932831106 1.0515317158072623 1.022965656713791 1.01149158199403 1.352088788799226 1.026625030388249 1.2175580031619504 1.0803178536331421 0.9153673641462766 1.0 11.011776192713628 -8.14359970939341 5.29151425873725 0.9600241181384319 1.112993898834103 0.2729873898204761 0.1008349012403586 0.297354051739719 11.388998027392496 0.07171561906945803 0.025939287635052422 7.184561895448105e-09 8.14359970939341 0.15296978069567113 S(ph)STDSLPGPISR ddPTM_A459_Selumetinib_30min_R2 2 SSTDSLPGPISR 12 0 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 S(0.499)S(0.499)T(0.002)DSLPGPISR;S(0.975)S(0.025)TDSLPGPISR 158.01 0.00045006 29724000.0 140598.0 139453.0 158629.0 170280.0 179778.0 108200.0 125788.0 134051.0 105730.0 149926.0 True False 132784.1260183881 150148.59668793075 148422.98284219598 147087.57025061562 157192.68040428817 123103.56785819324 131637.39124419357 134441.0662166623 126878.95434303016 145597.2468254707 0.9119961325749391 1.031259862131293 1.0194078945744938 1.0102359313629836 1.0796404728223814 0.8455075253295076 0.9041200579979991 0.9233764315462539 0.871437867881675 1.0 17.15162354955588 -6.764398894340912 24.999999233914366 0.9038013862835278 1.0121402527508045 0.46880674559169133 0.053935320046430396 65.26394357291926 551301.8078936863 0.017951664452441594 0.016512463137535554 1.7202877851610332e-07 6.764398894340912 0.10833886646727675 S(ph)STETCYSAIPK ddPTM_A459_Selumetinib_30min_R2 4 SSTETCYSAIPK 12 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 S(0.905)S(0.095)TETCYSAIPK;S(0.981)S(0.002)T(0.017)ETCYSAIPK;S(0.828)S(0.155)T(0.009)ET(0.008)CYSAIPK;S(0.94)S(0.06)TETCYSAIPK 270.02 9.685099999999998e-34 32932500.0 146662.0 130417.0 144533.0 159727.0 171834.0 118606.0 135108.0 137368.0 112614.0 141664.0 True False 138511.11317450332 140419.5645432504 135233.90413563204 137971.907055556 150246.67670454943 134942.8999019302 141390.78971142293 137767.71813750328 135139.94669806058 137573.7922327247 1.0068132231187827 1.0206854246316892 0.9829917598467125 1.002893827497012 1.0921169960219375 0.9808765006176179 1.0277450916831694 1.001409613718073 0.982308799552847 1.0 17.069846137667 -10.15168619300811 6.656801319130911 0.9999998619848424 1.0118306742376506 0.010058909319788034 0.031068624419550432 0.0 0.0 0.0298291846779067 0.0072346399501803105 7.052024411421249e-11 10.15168619300811 0.011830812252808243 S(ph)STGPEPPAPTPLLAER ddPTM_A459_Selumetinib_30min_R1 2 SSTGPEPPAPTPLLAER 17 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.91)S(0.09)TGPEPPAPTPLLAER;S(0.462)S(0.462)T(0.076)GPEPPAPTPLLAER 205.66 7.379e-09 10207900.0 1805.18 1880.95 1435.0900000000001 1298.98 1844.67 1389.38 1954.61 2053.0299999999997 755.54 1777.02 True False 1847.237181731174 1660.7274995700682 1240.2126603851066 1072.1375278745338 1677.8199242029414 1375.404098656106 1807.1721940344612 1998.5769752187111 1282.0961975417129 2005.1178266406039 0.921261163403078 0.8282443442999402 0.6185235819597557 0.534700511675568 0.8367687434179263 0.6859467709987263 0.9012798001313554 0.9967379216647575 0.6394118991449748 1.0 10.969471300851255 -7.268127855917625 24.494253287582424 0.8840855767537944 0.731571477542501 0.20780290643573673 0.14010762417821224 682.8070871764163 2500533.5409070365 0.05906523801516283 0.04088172197595523 5.393518144348751e-08 7.268127855917625 -0.15251409921129344 S(ph)STGPEPPAPTPLLAER ddPTM_A459_Selumetinib_30min_R2 1 SSTGPEPPAPTPLLAER 17 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.447)S(0.349)T(0.203)GPEPPAPTPLLAER 90.561 0.008914700000000001 2873100.0 9399.5 5920.6 8479.8 8178.6 11540.0 8883.2 11984.0 10750.0 11111.0 8836.6 True False 8877.113419179774 6374.690982270474 7934.218900108153 7064.660571128066 10090.24203109105 10106.780166339202 12541.279745845493 10781.280720241697 13333.510467278962 8581.464397755915 1.0344520477765045 0.7428441914805914 0.9245763348016663 0.8232465047545383 1.17581820111375 1.1777453937794302 1.4614381840382726 1.256345096888247 1.5537570103729295 1.0 13.06700814440431 -6.5235125978470645 1.828314464635039 1.3296908714714286 0.8699605561291006 0.5919277902039233 0.15902731599268904 0.21545468325406444 1.454956819026349 0.05634219799881577 0.061294946786875595 2.995624695240255e-07 6.5235125978470645 -0.459730315342328 S(ph)STPEEVKK ddPTM_A459_Selumetinib_30min_R2 1 SSTPEEVKK 9 1 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;E9PLJ3;E9PS23 P23528 CFL1 Cofilin-1 1 S(0.997)S(0.002)TPEEVKK 64.711 0.0464 4481700.0 13012.0 20062.0 18808.0 15627.0 16438.0 7938.1 11401.0 21392.0 7980.4 22358.0 True False 12288.845131163062 21600.690890502698 17597.913756602073 13498.575641921381 14372.911482415482 9031.501220102798 11931.169090652913 21454.247178363763 9576.70299100649 21712.46644693963 0.5659810764103759 0.9948520101707429 0.8104981439859633 0.6216970179278736 0.6619658580723491 0.415959248212254 0.5495077733250618 0.9881073267651606 0.44106932827782563 1.0 14.40623599903797 -10.49615121494647 15.640952062148349 0.9999999999644313 0.6821029186946643 0.20484960271327934 0.1928693339521372 0.0 0.0 0.18933930140619096 0.04592152581049317 3.1904268020313936e-11 10.49615121494647 -0.317897081269767 S(ph)STPLPTISSSAENTR ddPTM_A459_Selumetinib_30min_R2 2 SSTPLPTISSSAENTR 16 0 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 S(0.482)S(0.482)T(0.036)PLPTISSSAENTR;S(0.46)S(0.079)T(0.46)PLPTISSSAENTR 162.7 3.7387e-05 272026500.0 97856.0 76823.0 95713.0 104689.0 88865.0 60835.0 86279.0 87564.0 72138.0 77040.0 True False 92417.55526860537 82715.07707512144 89554.92978443493 90430.17760140171 77700.9842368202 69214.46904485383 90291.14445859504 87818.79674299934 86567.61570412836 74815.65502604106 1.235270281820531 1.105585148540514 1.197007895650497 1.208706621226877 1.0385658484146778 0.9251335034193362 1.2068482783070926 1.173802417588034 1.1570788984470803 1.0 16.19105256229995 -6.251643259037644 24.788984921526843 1.0905035512770676 1.1815930653117184 0.2565009047082395 0.08530765353958374 1085.9798165003126 2748061.8269225755 0.027177430525698886 0.03463686280520866 5.602175900764056e-07 6.251643259037644 0.09108951403465082 S(ph)STPLSEAK ddPTM_A459_Selumetinib_30min_R1 2 SSTPLSEAK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.333)S(0.333)T(0.333)PLSEAK;S(0.333)S(0.333)T(0.333)PLSEAK 149.33 0.0014374 112860000.0 25611.0 27134.0 29628.0 30005.0 26408.0 22055.0 25520.0 24042.0 14969.5 21578.0 True False 26207.686469669006 23957.138665745628 25604.680334954555 24765.190013607116 24019.40106271108 21833.146724337774 23595.005853730112 23404.3280605779 25402.14817097795 24347.746487518954 1.0763906418650895 0.9839571263002282 1.0516242375071518 1.0171450580160324 0.9865143402500848 0.896721457796096 0.9690837657532408 0.9612523307886146 1.0433059250062218 1.0 14.57150062899337 -6.264418697684198 3.5028967231308084 0.9690015426265123 1.0315864847935106 0.31247337557470745 0.04080102414707642 0.28719413221467643 7.6162146222071865 0.012909034851532991 0.015927660404029452 5.439779578547072e-07 6.264418697684198 0.06258494216699828 S(ph)STPLSEAK ddPTM_A459_Selumetinib_30min_R2 1 SSTPLSEAK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.333)S(0.333)T(0.333)PLSEAK 150.15 0.0013502 22830000.0 271550.0 301920.0 299080.0 337430.0 337460.0 276520.0 314730.0 301590.0 258660.0 319800.0 True False 256458.3381007787 325076.2931741883 279837.5184136833 291471.45190078346 295065.25786932296 314608.1200013637 329365.5686256639 302467.5769690875 310399.2275642502 310566.54305981344 0.8257758082182929 1.0467202615304907 0.9010549419027023 0.9385152986187815 0.9500870730061061 1.0130135619301783 1.060531393306683 0.9739219620667054 0.9994612571788487 1.0 18.244542892824192 -6.695314563910233 4.200520859499301 1.0111820809181473 0.9357630217518818 0.3337847495022357 0.05453978047601333 0.26987426810996645 9.381831766664924 0.01794566523476891 0.017525843506560865 2.0169049697117068e-07 6.695314563910233 -0.07541905916626557 S(ph)STPSDINSPR ddPTM_A459_Selumetinib_30min_R2 1 SSTPSDINSPR 11 0 Q674X7-3;A0A1B0GWK2;Q674X7-4;Q674X7-2;Q674X7;Q674X7-5 Q674X7-3 KAZN Kazrin 1 S(0.333)S(0.333)T(0.333)PSDINSPR 151.26 0.0021124000000000004 0.0 16347.0 18911.0 17892.0 16819.0 24461.0 16734.0 18080.0 16895.0 13102.0 18381.0 True False 15438.499182225845 20361.41289155102 16740.848199336677 14528.223185606685 21387.99049588544 19038.956603872495 18920.755824840333 16944.16165288218 15722.766100467015 17850.292770426586 0.8648877293376123 1.1406766910447947 0.9378472619268197 0.8138927115904939 1.1981870981589682 1.0665907191962265 1.0599689354220136 0.9492371845549987 0.8808127856880676 1.0 14.123660116267619 -7.907529247928313 6.936613627618534 0.9322278432548411 1.0153019647265114 0.06882783258914793 0.11412109942404487 0.5596890794502535 35.04157922028669 0.06390155747683934 0.030390044016913417 1.2372878609345166e-08 7.907529247928313 0.08307412147167026 S(ph)STQTLEDSWR ddPTM_A459_Selumetinib_30min_R1 2 SSTQTLEDSWR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.486)S(0.486)T(0.027)QTLEDSWR;S(0.861)S(0.123)T(0.015)QT(0.001)LEDSWR 187.74 1.9366e-05 14833000.0 2452.8999999999996 2595.3 3284.6000000000004 3289.5 3306.8 2374.0 3610.0 3374.1000000000004 2331.6 2384.4 True False 2510.047797487453 2291.441069477762 2838.569361016326 2715.0505765625935 3007.700523862958 2350.1197154195356 3337.6947935723274 3284.6079073785804 3956.554906673718 2690.4609660228107 0.9329433986169089 0.8516908806393493 1.05504944946756 1.0091395529800726 1.117912715273141 0.8735007662622266 1.2405661467396398 1.2208346260581773 1.4705862514417067 1.0 11.393637660574333 -7.2792752086665615 22.45585418419725 1.2513998144237028 0.9797501530458365 0.48837478047702754 0.12953677744476588 183.0880413505595 230511.0111588383 0.052726974482582505 0.03567467644005921 5.256840393795915e-08 7.2792752086665615 -0.2716496613778664 S(ph)STQTLEDSWR ddPTM_A459_Selumetinib_30min_R2 2 SSTQTLEDSWR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.858)S(0.141)TQTLEDSWR;S(0.982)S(0.012)T(0.006)QTLEDSWR 190.57 1.9835e-05 12259900.0 37081.0 38610.0 41820.0 51254.0 47930.0 39500.0 39581.0 47246.0 51575.0 67049.0 True False 35020.18646700413 41571.262849282684 39129.34673017326 44273.11678191838 41908.60490036342 44940.7664547008 41421.5949282636 47383.478038003625 61891.441125903424 65113.121155776724 0.5378360896450008 0.6384467847859349 0.6009441113498485 0.6799415539611335 0.6436276461099325 0.6901952426329625 0.6361482016683936 0.7277101327187699 0.9505218000199108 1.0 15.990660674383316 -8.206794449488548 2.1433091902458106 1.0047585100347942 0.6349759563093145 0.9204408971135187 0.03989661109694239 0.08099045783130915 0.6673795949160365 0.03725436421084625 0.011066104176125085 6.211629595704002e-09 8.206794449488548 -0.36978255372547975 S(ph)STVTEAPIAVVTSR ddPTM_A459_Selumetinib_30min_R2 2 SSTVTEAPIAVVTSR 15 0 Q8TD19 Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 1 S(0.998)S(0.002)TVTEAPIAVVTSR;S(0.855)S(0.145)TVTEAPIAVVTSR 215.37 1.2098e-07 11444000.0 32741.0 40044.0 43193.0 36040.0 40427.0 47202.0 34120.0 31025.0 25574.0 36295.0 True False 30921.386292607604 43115.24603824591 40414.00940498264 31131.289827532273 35348.19883803444 53703.64704290603 35706.64760749737 31115.27761353477 30689.51459726327 35247.06904426485 0.8772753914311326 1.2232292558595397 1.146592057178681 0.8832305968032748 1.0028691688844422 1.523634404195781 1.0130387738808966 0.8827763118249297 0.8706969240115258 1.0 15.105215675327324 -7.522061735509233 24.90457173865633 0.9156233975836949 1.1151286064622896 0.19177911907837653 0.17683959854323877 49.523232784814866 1509767.2331129925 0.08457021810356494 0.04960982402558436 3.0056490154547566e-08 7.522061735509233 0.1995052088785947 S(ph)SVDLEESSTK ddPTM_A459_Selumetinib_30min_R1 1 SSVDLEESSTK 11 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 S(0.5)S(0.5)VDLEESSTK 236.08 5.074999999999999e-09 19875000.0 5999.2 6650.5 5892.0 6375.3 6175.5 4960.7 6180.2 5568.0 2885.4 4771.6 True False 6138.969687588866 5871.856368266431 5091.8987624393185 5261.97353420262 5616.927115373076 4910.799861955224 5714.022538292434 5420.318552587046 4896.313058722053 5384.081339319928 1.140207456145952 1.0905957763647223 0.9457321391586712 0.9773205868519194 1.0432470762194241 0.9120961501996021 1.0612808719220022 1.006730435701719 0.9094054770243338 1.0 12.394484490105688 -5.101517029886784 4.253846630350362 0.9848807997557572 1.1307959667846443 0.5626806832960376 0.04776969169021834 0.15177079105045763 4.581856595899933 0.01199980412143753 0.03713373394351493 7.915584148228142e-06 5.101517029886784 0.14591516702888718 S(ph)SYPER ddPTM_A459_Selumetinib_30min_R2 2 SSYPER 6 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 S(0.905)S(0.095)YPER;S(0.995)S(0.005)YPER 108.09 0.02569 285575000.0 131766.0 114810.0 136284.0 143328.0 148829.0 109838.0 125760.0 140176.0 108821.0 153282.0 True False 124442.97322109083 123615.55782766495 127515.63581479974 123806.4791454091 130131.77047185859 124967.1874899097 131608.08918871253 140583.88895261398 130588.24071278563 148856.35038553568 0.8359937140658454 0.8304352317351764 0.8566355112464882 0.8317178193926709 0.8742104057691814 0.8395153257905799 0.8841281466853754 0.944426546724435 0.8772769208338379 1.0 17.183561244378858 -8.682486999431866 0.3060923111992294 1.0222081705602082 0.8223063819434986 0.8058934688628527 0.023083874517176046 0.9438502062892156 0.23709549802128602 0.06404297529164706 0.03148206393437217 2.0773659104124856e-09 8.682486999431866 -0.1999017886167096 S(ph)TAALEEDAQILK ddPTM_A459_Selumetinib_30min_R1 3 STAALEEDAQILK 13 0 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E9PDQ5;Q15052-2;Q15052 B1ALK7 ARHGEF7;ARHGEF6 Rho guanine nucleotide exchange factor 7;Rho guanine nucleotide exchange factor 6 1 S(0.96)T(0.04)AALEEDAQILK;S(0.989)T(0.011)AALEEDAQILK;S(0.998)T(0.002)AALEEDAQILK 226.93 6.7396e-13 78853900.0 7033.299999999999 7430.77 8354.8 7704.33 5599.52 7399.7 6842.6900000000005 5600.8099999999995 4089.92 4893.75 True False 7197.162205580538 6560.771993928748 7220.264049631374 6358.913393685514 5093.044404675551 7325.265736390039 6326.540384218679 5452.258324805145 6940.295524062005 5521.91048166169 1.3033826298855031 1.1881344356662655 1.307566298586319 1.151578500738742 0.9223337505360859 1.326581762003804 1.1457158541829267 0.9873862212928188 1.2568649106338798 1.0 12.430951784556635 -1.5228787452803376 0.19553971739363415 1.0516141402478816 2.135527808434263 0.22154336366764127 0.12238358081853254 88.5987469707572 1.0551751844294948 0.23684443591763624 29.222451129512983 0.029999999999999995 1.5228787452803376 1.0839136681863812 S(ph)TAALEEDAQILK ddPTM_A459_Selumetinib_30min_R2 4 STAALEEDAQILK 13 0 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E9PDQ5;Q15052-2;Q15052 B1ALK7 ARHGEF7;ARHGEF6 Rho guanine nucleotide exchange factor 7;Rho guanine nucleotide exchange factor 6 1 S(0.977)T(0.023)AALEEDAQILK;S(0.942)T(0.058)AALEEDAQILK;S(0.988)T(0.012)AALEEDAQILK;S(0.984)T(0.016)AALEEDAQILK 219.52 1.3957e-08 22973800.0 67471.5 67264.1 65153.0 66532.0 66255.9 76345.0 63548.3 67600.0 58584.8 73586.0 True False 63721.70413981466 72423.0401818294 60961.126913222804 57470.22682589835 57932.24150673881 86860.8307590921 66503.42186856753 67796.70480821755 70303.39699607989 71461.38098061112 0.8916942727023931 1.0134570475412334 0.8530639357468163 0.8042137730516452 0.8106790088825314 1.2154933135515413 0.9306204408030012 0.9487180890978321 0.9837956674130686 1.0 16.12487617361017 S(ph)TCGDSEVEEESPGK ddPTM_A459_Selumetinib_30min_R2 1 STCGDSEVEEESPGK 15 0 O95696;O95696-2 O95696 BRD1 Bromodomain-containing protein 1 1 S(0.994)T(0.006)CGDSEVEEESPGK 208.39 1.7100999999999994e-29 0.0 12986.0 13959.0 13437.0 14594.0 13076.0 12524.0 12561.0 12488.0 11024.0 15646.0 True False 12264.290107076815 15029.610414740668 12572.478049099422 12606.272023945781 11433.275979076825 14249.067318447427 13145.111389149315 12524.338012500304 13229.108036295866 15194.259326809986 0.8071660383890319 0.9891637421391908 0.8274492213592485 0.8296733491774917 0.7524734001941789 0.937792821089029 0.8651367010667649 0.824280917096192 0.8706648841351122 1.0 13.891238729198577 -8.57123582814564 19.628128465840156 1.0000000008954522 0.8561263605830659 0.31995470735075904 0.0633457683226776 2150.475015921901 872877.6739961123 0.06093923087849538 0.015734441761770978 2.683886660863839e-09 8.57123582814564 -0.14387364031238625 S(ph)TCGDSEVEEESPGKR ddPTM_A459_Selumetinib_30min_R2 2 STCGDSEVEEESPGKR 16 1 O95696;O95696-2 O95696 BRD1 Bromodomain-containing protein 1 1 S(0.969)T(0.031)CGDSEVEEESPGKR;S(0.957)T(0.043)CGDSEVEEESPGKR 142.4 0.00020251 16732000.0 34531.0 28225.0 28415.0 32081.0 41710.0 30656.0 34996.0 40672.0 30608.0 31406.0 True False 32611.90525854534 30389.766742320746 26586.809835912794 27711.51245718818 36470.016907868936 34878.585732539446 36623.383343258436 40790.34878638793 36730.4552589753 30499.227177412387 1.0692698889989447 0.9964110423370758 0.87172077119393 0.9085972013648668 1.1957685581908284 1.1435891647238325 1.2007970933237802 1.337422373003507 1.2043077368916986 1.0 14.896485066112174 -6.2688952360410495 24.54868570981435 1.1963731853034636 0.957580607094658 0.5711319470075114 0.09223878646001339 309.6567972797355 1019555.3294626984 0.02905425894611532 0.03360543851602036 5.383996438842585e-07 6.2688952360410495 -0.23879257820880562 S(ph)TDKEAQGQQFHHHR ddPTM_A459_Selumetinib_30min_R2 1 STDKEAQGQQFHHHR 15 1 A6ND36 A6ND36 FAM83G Protein FAM83G 1 S(0.5)T(0.5)DKEAQGQQFHHHR 66.82600000000001 0.026577 982740.0 5954.8 8897.2 7445.1 6645.4 6056.2 2684.8 5715.7 4661.5 5412.4 4848.1 True False 5623.856054953107 9579.586630992946 6966.090371611979 5740.285056045583 5295.36601288506 3054.6068298121704 5981.49137544469 4675.064193247134 6495.031235091412 4708.122756123451 1.1945007269911643 2.0346934706690902 1.479589792460654 1.2192301164152288 1.1247298099859082 0.6487950692957837 1.2704620684889911 0.9929783982727893 1.3795373594802478 1.0 12.200936221296248 -5.7934199964103525 2.6177617616713085 1.0646777010287194 1.6397456269634794 0.42184375065888935 0.26262507386289063 0.2363430537817112 3.3016244919087745 0.07497158369740416 0.13195304230767413 1.6090887689930008e-06 5.7934199964103525 0.57506792593476 S(ph)TDSPIIIEPLSKPDYR ddPTM_A459_Selumetinib_30min_R1 1 STDSPIIIEPLSKPDYR 17 1 A0A0D9SEJ8;Q86YH2 A0A0D9SEJ8 ZNF280B Zinc finger protein 280B 1 S(0.409)T(0.409)DS(0.183)PIIIEPLSKPDYR 76.704 0.011384 20151000.0 1522.5 1880.2 2144.8 2106.0 2026.6 1711.1 1721.1 1621.5 937.94 1348.9 True False 1557.9712877307043 1660.0653099187332 1853.5479405430854 1738.2266345161343 1843.2943878252902 1693.8878875544935 1591.2760413344395 1578.4925526256982 1591.6156755728023 1522.044454398662 1.0236043258974563 1.0906812249282174 1.217801448036809 1.142034077580791 1.2110647507687609 1.1129030316159356 1.0454859164827284 1.0370870233546088 1.0457090599246832 1.0 10.571794780956832 -7.218803586505407 3.470146260433813 1.0333468167859479 1.1407984968547047 0.4643716864218965 0.05348348665544325 0.23841123331912137 5.92933392114053 0.02400185439702808 0.017281363128786056 6.042218322240675e-08 7.218803586505407 0.10745168006875683 S(ph)TDSSSVSGSLQQETK ddPTM_A459_Selumetinib_30min_R1 4 STDSSSVSGSLQQETK 16 0 Q9H8G2;A0A3B3ISJ3 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 S(0.999)T(0.001)DSSSVSGSLQQETK;S(0.996)T(0.004)DSSSVSGSLQQETK;S(0.999)T(0.001)DSSSVSGSLQQETK;S(0.88)T(0.119)DSSSVSGSLQQETK 305.19 1.4046999999999999e-88 51652000.0 9480.3 10361.1 11555.1 11459.3 10377.7 8967.3 10017.4 9221.8 5827.33 8736.900000000001 True False 9701.172544547384 9148.01759525529 9985.98088762094 9458.148372702151 9439.03886733175 8877.097103656959 9261.779452944993 8977.20790737198 9888.55339865626 9858.366219612768 0.9840547945203482 0.9279445895462606 1.0129448090246729 0.9594032278782257 0.9574648229798174 0.9004633126730859 0.9394842153986029 0.910618220848018 1.0030620874058662 1.0 13.267132860052 -3.831652036621495 14.77018841887237 0.955406883411017 0.960924842014191 0.0 0.0380047566689671 0.0 0.0 0.008569077837233522 0.0 0.00014734926144175067 3.831652036621495 0.005517958603174056 S(ph)TDSSSVSGSLQQETK ddPTM_A459_Selumetinib_30min_R2 4 STDSSSVSGSLQQETK 16 0 Q9H8G2;A0A3B3ISJ3 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 S(0.584)T(0.415)DSSSVSGSLQQETK;S(0.997)T(0.003)DSSSVSGSLQQETK;S(0.963)T(0.035)DS(0.001)SSVSGSLQQETK;S(0.951)T(0.044)DS(0.005)SSVSGSLQQETK 195.89 1.0571e-06 68306000.0 164113.0 144945.0 153625.0 185980.0 169039.0 138543.0 165926.0 172248.0 126663.0 168211.0 True False 154992.2564563912 156061.81542836755 143740.9347542531 160649.20316660494 147802.80959216625 157626.04068186358 173641.88777613142 172749.21316280862 151999.13925991868 163354.31136533534 0.9488103201008099 0.9553577993992555 0.879933523350861 0.9834402399537499 0.9047989511682445 0.964933458838067 1.0629770731167807 1.057512420204582 0.9304874661065953 1.0 17.317645006368018 -7.032624983835796 7.635721519473211 1.017243175952486 0.9352130024947936 0.4235611898848737 0.042937747945006655 0.2255214467496579 45.22838437588886 0.01587612965706676 0.012568660228834745 9.276304927179855e-08 7.032624983835796 -0.08203017345769248 S(ph)TEFPR ddPTM_A459_Selumetinib_30min_R2 1 STEFPR 6 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.993)T(0.007)EFPR 96.492 0.037335 13366000.0 31453.0 30546.0 36487.0 34097.0 34057.0 28951.0 31363.0 28901.0 27946.0 34927.0 True False 29704.968176335078 32888.779979129446 34139.46614404188 29452.92977939422 29778.455186557003 32938.73745898845 32821.44164460552 28985.097125181885 33535.98087648079 33918.56675875571 0.8757730946478469 0.9696394370979594 1.0065126391352943 0.8683424034062779 0.8779396664474337 0.9711123023936639 0.9676541428783402 0.8545495843423188 0.9887204584734949 1.0 15.049787589140383 S(ph)TELLLGVK ddPTM_A459_Selumetinib_30min_R2 1 STELLLGVK 9 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 S(0.991)T(0.009)ELLLGVK 96.756 0.0212 3000700.0 20980.0 13638.0 20673.0 24554.0 23713.0 20062.0 27789.0 30446.0 23436.0 17423.0 True False 19814.015589594303 14683.990746918345 19342.921687060538 21209.702841987444 20733.96094309029 22825.35839529641 29081.24356285887 30534.592819393354 28123.854856552072 16919.952719609493 1.171044382803193 0.8678505779688283 1.1432018757737383 1.2535320395668905 1.225414827493018 1.3490202232564639 1.7187544223545592 1.804650008507712 1.662171007366808 1.0 14.046437916607772 -6.763872276825509 1.494333142798759 1.6083669847888955 1.0850389801736038 0.4111292486204057 0.22834665732159437 0.33045177050796926 1.5359168498851525 0.10065822679766165 0.0910423844656445 1.7223750397735607e-07 6.763872276825509 -0.5233280046152917 S(ph)TELVLSPDMPR ddPTM_A459_Selumetinib_30min_R1 4 STELVLSPDMPR 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 S(0.993)T(0.007)ELVLSPDMPR;S(0.992)T(0.008)ELVLSPDMPR;S(0.993)T(0.007)ELVLSPDMPR;S(0.993)T(0.007)ELVLSPDMPR 260.7 3.6753000000000005e-25 81160000.0 4092.4399999999996 4937.03 4666.64 5262.66 5168.6 3976.04 4552.32 4523.43 2698.94 3981.12 True False 4187.78588949796 4359.00023243702 4032.9359200186414 4343.635223363093 4701.101042590444 3936.0446475554727 4208.934837306142 4403.453942228596 4579.904057221635 4492.135531392689 0.9322483393994189 0.9703625818888877 0.897776990884404 0.9669421576905192 1.0465180780360317 0.876207901575754 0.936956333550616 0.9802584787247951 1.0195382630856946 1.0 12.133185740343261 -7.984274405839184 4.01591118244197 1.0082061297443285 0.9478487182974014 0.2561192165873155 0.04339790210469812 0.31306456584504744 11.369336353302815 0.029092287013997648 0.011800892734436401 1.0368730680243387e-08 7.984274405839184 -0.06035741144692719 S(ph)TELVLSPDMPR ddPTM_A459_Selumetinib_30min_R2 5 STELVLSPDMPR 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 S(0.992)T(0.008)ELVLSPDMPR;S(0.993)T(0.007)ELVLSPDMPR;S(0.986)T(0.014)ELVLSPDMPR;S(0.992)T(0.008)ELVLSPDMPR;S(0.6)T(0.4)ELVLSPDMPR 254.18 7.8028e-19 51024400.0 62154.0 67008.29999999999 72918.9 81793.5 80046.1 55943.100000000006 59869.7 64659.9 53676.5 66514.0 True False 58699.72950217559 72147.62114435624 68227.37736209539 70653.08419834246 69989.99329678652 63648.754224100645 62653.759679559946 64848.0496039773 64413.299846719405 64593.56799587356 0.9087550250502575 1.1169474513153577 1.0562565202537497 1.093809900745164 1.0835443135957081 0.9853729434510681 0.9699690174037523 1.0039397360449263 0.9972091935041323 1.0 15.97910289303758 -6.772367647766346 24.988216247186152 0.9902113239084909 1.0580529724571353 0.23972338590908626 0.05334458950379392 284.35409510943765 650189.9771749482 0.018212871656759905 0.016214049839871705 1.6890105108667073e-07 6.772367647766346 0.06784164854864438 S(ph)TENVNKLPELSSFGK ddPTM_A459_Selumetinib_30min_R2 2 STENVNKLPELSSFGK 16 1 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 S(0.5)T(0.5)ENVNKLPELSSFGK;S(0.742)T(0.258)ENVNKLPELSSFGK 65.765 0.030172000000000008 17228300.0 69238.0 48016.0 62659.0 63725.0 59864.0 59200.0 72553.0 68333.0 63535.0 61535.0 True False 65390.02914167439 51698.672804225775 58627.58815796092 55045.54506824343 52343.34912904978 67354.26263590614 75926.85826104217 68531.83771686295 76243.77531622442 59758.32466286925 1.094241338099366 0.8651292200021911 0.9810781759480799 0.9211360154218966 0.8759172788786905 1.12711095928291 1.2705653762783484 1.1468165833545383 1.2758686885276485 1.0 15.866852081986329 -6.890225013724825 5.189129428712502 1.1871227618046853 0.9442176210389343 0.5740088845614149 0.09343722008779184 0.13537340759781663 5.649229060109513 0.03130219408671116 0.027565459281350336 1.2875822654128848e-07 6.890225013724825 -0.2429051407657511 S(ph)TENVNKLPELSSFGKPSSSVQGTGLIR ddPTM_A459_Selumetinib_30min_R1 2 STENVNKLPELSSFGKPSSSVQGTGLIR 28 2 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 S(0.824)T(0.176)ENVNKLPELSSFGKPSSSVQGTGLIR;S(0.803)T(0.197)ENVNKLPELSSFGKPSSSVQGTGLIR 119.65 4.5614e-12 82294000.0 1036.52 1503.8600000000001 1725.8899999999999 1889.65 1404.49 1424.76 1452.0500000000002 1311.75 618.1600000000001 1284.9 True False 1060.6688992831719 1327.787372074453 1491.523617635167 1559.6581006236524 1277.45412748285 1410.4282079785767 1342.5206994478378 1276.9581288354987 1048.9723713799208 1449.8294309858704 0.7315818513643546 0.9158231607780027 1.0287579943945164 1.0757528211874547 0.8811064944475525 0.9728235458839449 0.9259852716156661 0.8807643861713988 0.7235143313835404 1.0 10.501667465215705 -7.82684612934558 3.7775711981090145 0.8457218837727956 0.9417029102930673 0.06454742949200154 0.10686564840474078 0.5009092433038375 14.097734925800834 0.06405052279822085 0.029295373011893902 1.4898888522403053e-08 7.82684612934558 0.09598102652027174 S(ph)TEPELIQVK ddPTM_A459_Selumetinib_30min_R1 2 STEPELIQVK 10 0 M0QXM4;Q15758-3;Q15758-2;Q15758 M0QXM4 SLC1A5 Amino acid transporter;Neutral amino acid transporter B(0) 1 S(0.995)T(0.005)EPELIQVK;S(0.993)T(0.007)EPELIQVK 168.02 0.00027838 24006000.0 10898.7 6772.3 9456.1 5155.5 10763.3 7392.299999999999 9064.1 12776.3 4952.0 10120.8 True False 11152.618504821436 5979.395967643144 8172.013558639249 4255.188705720766 9789.761415414961 7317.940173671372 8380.387639451223 12437.431020728785 8403.182320229984 11419.9032649403 0.9765948315044451 0.5235942747431322 0.715593938849531 0.3726116243720223 0.8572543206622459 0.6408057935252246 0.7338405102939402 1.089101258756924 0.7358365587936452 1.0 13.479262809603796 -7.593570427696817 7.123095676583153 0.9330450807955558 0.6708714417782023 0.305036953134716 0.17595221216653842 0.2646924828165597 22.056668283451955 0.0792395873476596 0.045443121034922096 2.5493506368805588e-08 7.593570427696817 -0.26217363901735347 S(ph)TEPELIQVK ddPTM_A459_Selumetinib_30min_R2 3 STEPELIQVK 10 0 M0QXM4;Q15758-3;Q15758-2;Q15758 M0QXM4 SLC1A5 Amino acid transporter;Neutral amino acid transporter B(0) 1 S(0.986)T(0.014)EPELIQVK;S(0.99)T(0.01)EPELIQVK;S(0.984)T(0.016)EPELIQVK 140.91 0.001367 18135800.0 240830.0 88016.8 179154.0 202007.0 134513.0 116342.9 282827.0 192666.0 139189.0 149415.0 True False 227445.6327188747 94767.40554138148 167627.42668812667 174493.29811848843 117614.27437852252 132368.07841930666 295979.01591106836 193226.62616242675 167030.68926560125 145101.00072320795 1.5674987187217673 0.6531133835676163 1.1552465238188792 1.2025644016842358 0.8105683199448181 0.9122478670688814 2.039813746534199 1.3316698382461356 1.1511339579540598 1.0 17.146697943761737 S(ph)TEPSVTPDLLNFK ddPTM_A459_Selumetinib_30min_R1 4 STEPSVTPDLLNFK 14 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(0.991)T(0.009)EPSVTPDLLNFK;S(0.995)T(0.005)EPSVTPDLLNFK;S(0.988)T(0.012)EPSVTPDLLNFK;S(0.961)T(0.039)EPSVTPDLLNFK 244.0 5.896099999999998e-20 49817100.0 9009.849999999999 11602.4 10805.2 11555.6 10068.199999999999 9355.0 10114.4 9723.300000000001 5428.09 9096.82 True False 9219.76197488374 10243.985614190577 9337.913188715103 9537.631385477038 9157.533087685084 9260.897193660385 9351.462664849843 9465.406498270404 9211.072277992163 10264.48545753046 0.898219595422558 0.998002837704364 0.9097302760426648 0.9291874809447783 0.8921570521556667 0.9022271239973554 0.9110503106601623 0.9221510944151791 0.8973730165143867 1.0 13.325373688781188 -11.392855706335721 2.4904554190507215 1.0384347877171614 0.9189647801257863 0.41935988869686325 0.028991302891679588 17534865.365079347 9844620.505239492 3978712.7949431734 0.007245063580814897 4.047103337393177e-12 11.392855706335721 -0.11947000759137505 S(ph)TEPSVTPDLLNFKK ddPTM_A459_Selumetinib_30min_R1 2 STEPSVTPDLLNFKK 15 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(0.838)T(0.158)EPS(0.003)VTPDLLNFKK;S(0.844)T(0.156)EPSVTPDLLNFKK 101.9 0.0034124000000000003 22880100.0 3053.4 2980.4 4278.299999999999 4806.1 4130.3 3252.9 3361.5 3324.3 1902.73 2243.6800000000003 True False 3124.538279117855 2631.4533824496316 3697.330359019712 3966.804856670462 3756.715094263692 3220.1787793968883 3107.939348640824 3236.1287651517787 3228.7938400991925 2531.678183293934 1.2341767210919985 1.0394106959621072 1.460426678010537 1.5668677333662144 1.4838833462537004 1.271954232037168 1.2276202280169448 1.27825439524912 1.2753571371769892 1.0 11.305878311516185 -6.989848756340602 24.50921565259894 1.2229659864749556 1.3588419281556785 0.18536198093346157 0.15567415108454863 370.8479716117416 895371.4869973963 0.06066137972450493 0.05343559551744349 1.0236494175525588e-07 6.989848756340602 0.13587594168072292 S(ph)TFGSGPPTSR ddPTM_A459_Selumetinib_30min_R2 1 STFGSGPPTSR 11 0 E9PRZ5 E9PRZ5 GPR89A 1 S(0.837)T(0.163)FGSGPPTSR 80.737 0.043217 23689000.0 12300.0 11362.0 11787.0 17451.0 14123.0 12535.0 18001.0 18275.0 15286.0 16259.0 True False 11616.415240801241 12233.428865411799 11028.637252715253 15074.14369534588 12348.74247877806 14261.582468599356 18838.082168304813 18328.177224410887 18343.62712652564 15789.560424044714 0.7357022569869324 0.7747795718734796 0.6984765222419101 0.9546905227577216 0.7820827272666252 0.90322859443772 1.1930719831577918 1.160778180784584 1.1617566692098364 1.0 13.94668338717076 -7.095489867729057 3.4043492084487994 1.1418458341879654 0.7941963204546595 0.8001429754605973 0.07988559254384503 0.10664607329690644 2.3248274487860194 0.032427423919499355 0.024911532829004792 8.026202861193824e-08 7.095489867729057 -0.3476495137333059 S(ph)TFSPISDIGLAK ddPTM_A459_Selumetinib_30min_R2 1 STFSPISDIGLAK 13 0 Q8TEK3-1;Q8TEK3;H7C2S2 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 S(0.779)T(0.126)FS(0.094)PISDIGLAK 99.941 0.011333 6414700.0 70136.0 65126.0 75744.0 83275.0 82136.0 63096.0 64218.0 73435.0 57032.0 74274.0 True False 66238.12189665335 70120.9547869045 70870.71350383176 71932.80134261235 71817.34137484343 71786.90127153933 67204.26424555291 73648.6836921814 68439.99360722292 72129.51663297234 0.9183219989356496 0.9721533993318116 0.982548016569334 0.9972727490832779 0.9956720178825347 0.9952499978174484 0.9317165479912842 1.0210616558951762 0.9488486378673049 1.0 16.13830213535224 -4.732421244593316 2.662305934155926 0.9841131722238865 0.8999648626588411 0.3895913008218289 0.024580707242431193 0.5747750915611287 4.789316218312546 0.0059938468289836705 0.11491288599551724 1.8517346592222816e-05 4.732421244593316 -0.08414830956504538 S(ph)TFSTNYR ddPTM_A459_Selumetinib_30min_R1 5 STFSTNYR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.933)T(0.067)FS(0.001)TNYR;S(0.94)T(0.011)FS(0.013)T(0.036)NYR;S(0.976)T(0.016)FS(0.005)T(0.004)NYR;S(0.959)T(0.008)FS(0.031)T(0.002)NYR;S(0.802)T(0.01)FS(0.048)T(0.139)NYR 163.88 0.00059259 2903177700.0 44924.26 44517.88 39238.899999999994 42266.55 31157.04 45244.52 36333.92 34693.54 31455.14 26514.99 True False 45970.90785060691 39305.705913799065 33910.47290384935 34885.49048390689 28338.891233222203 44789.4012075373 33593.22316179319 33773.35461869984 53377.07518747155 29918.44724437391 1.5365405655954163 1.31376155964078 1.133430242113455 1.1660194193556292 0.9472046126508541 1.4970496577478578 1.1228264250281341 1.1288471738803503 1.7840857432034336 1.0 14.868747681413636 S(ph)TFSTNYR ddPTM_A459_Selumetinib_30min_R2 3 STFSTNYR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.976)T(0.013)FS(0.01)T(0.001)NYR;S(0.838)T(0.012)FS(0.108)T(0.042)NYR;S(0.866)T(0.014)FS(0.081)T(0.039)NYR 129.88 0.003963800000000001 955660000.0 301509.0 195215.0 203683.0 296664.0 206276.0 261380.0 126591.0 114919.0 137540.0 135171.0 True False 284752.3368161576 210187.36278484087 190578.2575332825 256257.8514260549 180361.7647491626 297382.72242860025 132477.73233530764 115253.39526413553 165051.84318869116 131268.2620135649 2.1692397876550853 1.6012047357122827 1.451822813907513 1.9521691496119138 1.3739936979627605 2.2654579093754554 1.0092137299846153 0.8779989427469189 1.2573629044592298 1.0 17.002158618614892 -7.288950914603838 24.776640294278035 1.0259769516008561 1.7645842981362543 0.6353990902808455 0.2834210664908696 432.92559866849774 389886.95471847674 0.11338810272649485 0.07646735397354736 5.141017537764253e-08 7.288950914603838 0.7386073465353982 S(ph)TGGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R1 1 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 S(0.895)T(0.105)GGAPTFNVTVTK 164.7 0.00025862 13771000.0 1107.5 1624.9 1444.7 1261.7 1348.8 1200.7 1429.0 1523.3 758.89 1241.8 True False 1133.3025951801355 1434.655952604485 1248.5176751690572 1041.3677800422638 1226.8012781499806 1188.6220481483729 1321.2093795054996 1482.8971356242535 1287.7809028673937 1401.1971261563183 0.8088102480547792 1.0238787432714405 0.8910364229720608 0.74319862680484 0.8755379633951076 0.8482903839582737 0.9429147083178536 1.0583072916314422 0.9190576249609922 1.0 10.452444218962174 -7.46060467741836 4.52132075408209 0.9935210905717194 0.8691977182324239 0.3797896619234348 0.07372350321809745 0.24468557952440395 9.995711614876932 0.03409464201448221 0.021733540526571435 3.462544173103853e-08 7.46060467741836 -0.12432337233929558 S(ph)TGGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R2 1 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 S(0.988)T(0.012)GGAPTFNVTVTK 157.91 0.00030978 3721200.0 36917.0 33038.0 37527.0 41545.0 43342.0 34799.0 29314.0 39482.0 28702.0 34366.0 True False 34865.3009304601 35571.90836608655 35112.55367630825 35886.49933087758 37896.9904776038 39592.24637612997 30677.15908458904 39596.886083403035 34443.20200088569 33373.7642864088 1.044691891248801 1.065864433535684 1.0521004875259923 1.075290729056059 1.1355323946192384 1.1863284595754637 0.9191998487591065 1.1864674821691767 1.0320442640302465 1.0 15.026426799394608 -5.890483309898425 5.206088560802588 1.085306315604834 1.0556771165664993 0.009039053968195043 0.07805284825488544 0.9756937388621912 40.804984276193416 0.021526560672570534 0.03252312984582428 1.286816704933225e-06 5.890483309898425 -0.029629199038334608 S(ph)TGSMSVVSAALVAEPVQNGSR ddPTM_A459_Selumetinib_30min_R1 1 STGSMSVVSAALVAEPVQNGSR 22 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.827)T(0.168)GS(0.005)MSVVSAALVAEPVQNGSR 200.4 1.0797e-27 0.0 175.61 194.22 219.29 236.54 145.72 145.95 182.85 208.94 61.824 130.03 True False 179.70137132242309 171.48063210957164 189.51162247374722 195.23272940572 132.53965172895553 144.48187551199717 169.05747728662047 203.3982324672301 104.91081255369522 146.72061709945726 1.2247860926089837 1.1687562082248493 1.2916495733199056 1.3306427771727398 0.9033471529029291 0.9847414655709735 1.152240773169743 1.3862961899168735 0.7150379723565333 1.0 7.196927801735096 -6.307857919618912 0.3299774334132599 0.9855458271603084 1.3122704572976844 0.19068507641377286 0.18050572108143986 5.345071770097362 0.9840782530041143 0.22114780911285545 0.6506832567916788 4.922005338160533e-07 6.307857919618912 0.32672463013737607 S(ph)TGSMSVVSAALVAEPVQNGSR ddPTM_A459_Selumetinib_30min_R2 1 STGSMSVVSAALVAEPVQNGSR 22 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.833)T(0.166)GSMSVVSAALVAEPVQNGSR 212.55 1.0021e-23 2274500.0 1230.4 1059.1 870.06 2446.0 3507.5 2112.3 3091.1 2230.5 2610.6 1064.3 True False 1162.0192936814512 1140.3295644567547 814.0812868497015 2112.8505804146484 3066.856492552154 2403.2501514497344 3234.84227489845 2236.9903857208474 3132.7929462585253 1033.5708936165065 1.1242763325266432 1.1032910964304492 0.7876395241754517 2.0442241489809168 2.967243477436849 2.3251913983768104 3.1297729985212777 2.1643318320367237 3.031038282528212 1.0 10.013421632652555 -5.9049045072978625 4.261735285623108 2.5237391197577703 1.0217758821839127 0.5420488499381473 0.5837109488512832 0.14404002900155943 4.768345809729299 0.15458002419870537 0.2358529211766884 1.2447882858209957e-06 5.9049045072978625 -1.5019632375738576 S(ph)TGSPTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R2 1 STGSPTQETQAPFIAK 16 0 O15231-3;O15231-2;H0Y704 O15231-3 ZNF185 Zinc finger protein 185 1 S(0.846)T(0.01)GS(0.143)PT(0.001)QETQAPFIAK 195.28 1.2514e-06 15836000.0 34757.0 34816.0 41720.0 39558.0 35794.0 32136.0 31201.0 28797.0 26378.0 32799.0 True False 32825.34508329501 37486.27524891544 39035.780621301456 34170.13215864375 31297.23771757998 36562.44229843712 32651.908323608604 28880.79450240002 31654.33706290026 31852.00764796373 1.03055811885043 1.1768889315619608 1.2255359553072624 1.072777971683936 0.9825828897030542 1.1478850156804645 1.025113037912259 0.9067181830921839 0.9937940933818624 1.0 14.959096688686525 -6.979784086502332 0.8000821582167273 0.962656466543114 1.1359702714962578 0.4000140262912202 0.07281230211638702 0.6442082098896744 0.8646115541415827 0.05648141209152466 0.043579849868746905 1.0476492670727055e-07 6.979784086502332 0.17331380495314386 S(ph)TGVVNIPAAECLDEYEDDEAGQKER ddPTM_A459_Selumetinib_30min_R1 1 STGVVNIPAAECLDEYEDDEAGQKER 26 1 Q96IZ0;H0YI16 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 S(0.798)T(0.202)GVVNIPAAECLDEYEDDEAGQKER 101.86 6.820100000000001e-07 4166900.0 340.73 314.87 539.13 654.6 513.86 612.54 410.2 327.22 194.44 317.03 True False 348.66834605483274 278.0048740209082 465.91910722910944 540.2863983638468 467.3814537293513 606.378403741821 379.25828374608557 318.5410626396431 329.9504786642807 357.72388863370736 0.9746856643724259 0.7771493122327434 1.3024545523326483 1.5103447534002266 1.3065424719452499 1.6951017894215175 1.0601983702979043 0.8904662863201018 0.9223607624430546 1.0 8.48270265382386 -7.5135070907305215 24.189448757974496 0.9389144539581794 1.2646094523586717 0.2732632383090875 0.2401928401951586 444.3077067242076 1146828.8641982805 0.12008736070735818 0.07431820709673548 3.065440629536176e-08 7.5135070907305215 0.3256949984004923 S(ph)TLEPVEK ddPTM_A459_Selumetinib_30min_R1 1 STLEPVEK 8 0 A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;V9GZ37;P17066;P48741 A0A0G2JIW1;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 1 S(0.984)T(0.016)LEPVEK 112.3 0.011233 6581300.0 1435.8 1896.3 1778.3 1658.2 2190.5 1797.5 2365.1 2200.9 1062.8 1580.2 True False 1469.251346419537 1674.2803144340467 1536.81662750269 1368.6264982690666 1992.3696617641867 1779.4187819994181 2186.698602847067 2142.5249824692564 1803.4939761592157 1783.0340624514522 0.824017542547391 0.9390063542208036 0.8619109751553239 0.7675829234509259 1.1174041504428265 0.9979723996707817 1.2263919399501688 1.2016175280036705 1.0114747744525046 1.0 10.800118548623534 -6.272340585513514 24.826989356264583 1.1045282259774287 0.8556050515420027 0.6665914193674995 0.0843346577276225 395.5302430468631 900799.9134604263 0.026586628461348644 0.030440373884873164 5.341453038644108e-07 6.272340585513514 -0.248923174435426 S(ph)TLSPPEASPGPPAAPR ddPTM_A459_Selumetinib_30min_R2 1 STLSPPEASPGPPAAPR 17 0 Q6NUJ5-2;Q6NUJ5 Q6NUJ5-2 PWWP2B PWWP domain-containing protein 2B 1 S(0.617)T(0.083)LS(0.294)PPEAS(0.006)PGPPAAPR 133.23 0.00064586 4480400.0 12134.0 10473.0 11670.0 12146.0 13103.0 9631.4 9717.4 10617.0 8586.5 12817.0 True False 11459.64085625058 11276.245423997338 10919.164905335288 10491.693846981327 11456.883997693752 10958.037924855838 10169.278354662803 10647.893712261037 10304.039926855443 12446.939907434707 0.9206793751294323 0.9059451967998897 0.8772569793490478 0.842913513281647 0.920457886267324 0.8803800778623885 0.8170103198287774 0.8554627716890415 0.8278372036407692 1.0 13.603503477424074 -7.009979048658067 24.45620378667025 0.8609845757312574 0.8914356261849542 0.0 0.05181863323482951 1058.7329907805108 2594695.084027669 0.01804106761020563 0.014977175536788012 9.772843662129875e-08 7.009979048658067 0.030451050453696782 S(ph)TLTDSLVCK ddPTM_A459_Selumetinib_30min_R2 2 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 1 S(0.999)T(0.001)LTDSLVCK;S(0.85)T(0.14)LT(0.01)DSLVCK 120.96 0.0049258 3482000.0 34466.0 29758.0 36306.0 35857.0 38162.0 27840.0 32960.0 39592.0 28595.0 34897.0 True False 32550.517698329706 32040.34291294883 33970.11148698399 30973.214743224868 33367.748387391366 31674.707293642303 34492.705309000965 39707.20616519156 34314.79901105591 33889.43293670509 0.9604916600146111 0.9454375637618433 1.0023806403143298 0.913949041315421 0.9846062768212125 0.9346484891854283 1.0178011940601839 1.1716692409504832 1.0125515842990136 1.0 15.048547876322731 -7.522248906912775 24.995497608827673 1.0742133001117447 0.9593068363934231 0.4756756118219636 0.04915483697168723 17.101284566743495 678769.401615024 0.021134318580784933 0.012389272028540184 3.004353925699704e-08 7.522248906912775 -0.11490646371832158 S(ph)TNTAVSR ddPTM_A459_Selumetinib_30min_R2 3 STNTAVSR 8 0 Q9NWB6-2;Q9NWB6 Q9NWB6-2 ARGLU1 Arginine and glutamate-rich protein 1 1 S(0.954)T(0.046)NTAVSR;S(0.986)T(0.014)NTAVSR;S(0.954)T(0.046)NTAVSR 149.94 0.0013542 29133500.0 11827.5 4518.35 12570.5 13576.2 11773.7 15478.100000000002 36010.4 112516.0 22890.9 29061.8 True False 11170.174899233869 4864.892916214875 11761.727715725554 11727.098139748705 10294.582547786538 17610.067778797587 37684.954953253895 112843.40293197344 27469.71962518552 28222.710322375453 0.3957867537044435 0.17237511424825502 0.41674692406847447 0.4155199130698393 0.3647623644290752 0.623967988107649 1.3352705860916771 3.998319142386167 0.9733196886979013 1.0 14.784568921024347 -7.403930499907983 3.685262007463593 2.1910074689550982 0.3882278002439178 0.43454855816878857 0.8018417111278099 0.1890370739896114 4.599600416884152 0.3421613586929152 0.2180163201194111 3.94520432079562e-08 7.403930499907983 -1.8027796687111803 S(ph)TPAMMNGQGSTTSSSK ddPTM_A459_Selumetinib_30min_R2 2 STPAMMNGQGSTTSSSK 17 0 Q6ZN18-2;Q6ZN18;F5GZR7;A0A669KBC9;A0A669KBL4;G5EA50;Q6ZN18-3 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.998)T(0.002)PAMMNGQGSTTSSSK;S(0.573)T(0.427)PAMMNGQGSTTSSSK 176.49 9.3403e-08 11080100.0 78091.0 76959.0 84249.0 84108.0 80423.0 67064.0 74474.0 73898.0 55869.0 75667.0 True False 73751.01484304147 82861.50783781265 78828.51106337571 72652.34530560717 70319.54374925779 76301.45725362166 77937.1885674314 74113.03094552744 67044.36111028794 73482.29710352368 1.0036569044533163 1.1276390519076356 1.0727551283858228 0.9887054184391207 0.9569589754412532 1.0383651608784938 1.0606253701844888 1.0085834801968039 0.9123879322367151 1.0 16.165109106271743 -5.7562654382575245 24.40254898933754 0.9983921632040798 1.0739792642509192 0.326990962086504 0.04755064392602091 111.50181611291683 525879.9976754598 0.013381335422092175 0.022296180452486936 1.7528088678171857e-06 5.7562654382575245 0.07558710104683941 S(ph)TPEHTWSSR ddPTM_A459_Selumetinib_30min_R1 2 STPEHTWSSR 10 0 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(0.858)T(0.14)PEHT(0.002)WSSR;S(0.855)T(0.145)PEHTWSSR 129.0 0.0030223000000000003 26127000.0 6668.5 7951.0 6162.5 6575.9 9010.9 6608.0 8546.3 7356.0 2560.1000000000004 5461.799999999999 True False 6823.863075357767 7020.093223680383 5325.66634818946 5427.542509930982 8195.86568600361 6541.529519583954 7901.6457103343955 7160.894984344521 4344.302717694024 6162.875232437254 1.1072531599279367 1.1390938415775977 0.8641528746450542 0.8806834967815067 1.329876944914616 1.0614411736187221 1.2821362452294045 1.1619406063349065 0.7049149226368432 1.0 12.589387868667183 -8.248763437200736 24.96739563942641 0.8524574479645853 1.101237324515987 0.29536970697579334 0.1549609891481667 864.6015239019627 1702986.4533272914 0.110298254713053 0.04108088366352999 5.639447562570242e-09 8.248763437200736 0.24877987655140166 S(ph)TPEHTWSSR ddPTM_A459_Selumetinib_30min_R2 4 STPEHTWSSR 10 0 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(0.997)T(0.003)PEHTWSSR;S(0.869)T(0.131)PEHTWSSR;S(0.99)T(0.01)PEHTWSSR;S(0.775)T(0.225)PEHTWSSR 119.74 0.0035091 42553000.0 141397.0 112524.0 143779.0 160497.0 182894.0 135314.0 134780.0 154836.0 138651.0 156209.0 True False 133538.72079703832 121154.22897831324 134528.41567473902 138637.0317272321 159917.2206268948 153952.27524180745 141047.5370615033 155286.54712552048 166385.07423262505 151698.84029027613 0.880288343282728 0.7986496715893431 0.8868124200377442 0.913896450770156 1.0541756306171672 1.0148546616916738 0.9297865217137353 1.0236501928978445 1.0968117746598904 1.0 17.21085053092576 -5.96665254336447 2.3030250636312037 1.0162066224839454 0.845179979059656 0.7243445873168648 0.04607991901317042 0.1621412725882825 1.7355675155412256 0.014840249800845784 0.023486934150703423 1.079810277300444e-06 5.96665254336447 -0.17102664342428942 S(ph)TPKEDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R1 2 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.753)T(0.244)PKEDDS(0.001)S(0.001)ASTSQSTR;S(0.535)T(0.463)PKEDDS(0.001)SASTSQSTR 69.612 0.018633 25069000.0 4708.1 5311.9 7220.0 7669.6 5025.4 4726.200000000001 5592.700000000001 5038.0 3666.1 5110.1 True False 4817.789569632138 4689.980278564689 6239.563656621167 6330.248336222673 4570.853457306433 4678.658719046258 5170.838136291398 4904.375874269673 6221.103938650072 5766.031111589149 0.8355469258479824 0.813381022023675 1.0821245213332729 1.0978519216622857 0.7927209147587622 0.8114175294064264 0.8967759688112898 0.8505635469798914 1.0789230613317837 1.0 12.493362905819271 -8.264250149291842 24.98344301464813 1.0394615395234978 0.9011806304869263 0.22766943357157676 0.10438088395611321 431.9302331011043 3839090.003358354 0.0945426641822902 0.02873822767606107 5.441891150488381e-09 8.264250149291842 -0.13828090903657153 S(ph)TPKEDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R2 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.499)T(0.499)PKEDDS(0.001)SASTSQSTR 84.41 0.0067587 13131000.0 28463.0 33468.0 33548.0 30537.0 26749.0 23044.0 21736.0 26668.0 19631.0 27106.0 True False 26881.140406416725 36034.8879834186 31389.558204300618 26377.80792073677 23388.551480905935 26218.10182739559 22746.767069066897 26745.59946487493 23557.74853596917 26323.37935015413 1.0211888089611614 1.368930922739128 1.19245928825308 1.0020676893288902 0.8885086967668909 0.9960006076211516 0.8641279209059345 1.0160397382533761 0.8949363310311916 1.0 14.684057091219469 -5.809535611540909 3.752387665987395 0.9432647215321152 1.2155379639896235 0.5970614338830245 0.09195266212967666 0.13246868854238272 3.8337306073221304 0.024693086276340728 0.040058189049407764 1.5504736449083525e-06 5.809535611540909 0.2722732424575084 S(ph)TPLEENVVDR ddPTM_A459_Selumetinib_30min_R1 1 STPLEENVVDR 11 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 S(0.5)T(0.5)PLEENVVDR 140.01 0.0011217 5218300.0 2784.3 2870.3 1904.8 1928.9 2043.7 1628.1 2034.2 2259.8 952.34 1805.6 True False 2849.1687726953064 2534.2439416337306 1646.1386223174516 1592.0538249374038 1858.8476958445399 1611.7227921965236 1880.7586562561848 2199.862763135093 1616.0514238384144 2037.3663480333785 1.3984567750643087 1.2438823013249318 0.8079737961248011 0.7814273689531466 0.9123777359132498 0.7910814830883417 0.9231322869702038 1.0797580735828725 0.7932061042425436 1.0 10.992489705795343 -5.127796683789375 3.9053793568246786 0.8846079069693462 1.3687752377435325 0.7745405232454284 0.09520611965233657 0.10232676099330408 2.6435980925007976 0.02532664887982873 0.07981965673818557 7.450807039443509e-06 5.127796683789375 0.4841673307741863 S(ph)TPLEENVVDR ddPTM_A459_Selumetinib_30min_R2 1 STPLEENVVDR 11 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 S(0.977)T(0.023)PLEENVVDR 131.12 0.0022643 7542000.0 38968.0 31922.0 32076.0 40950.0 36585.0 29854.0 41731.0 36639.0 42038.0 28423.0 True False 36802.314561263636 34370.31475459213 30012.265081708203 35372.53935730984 31988.86522595025 33966.11751237059 43671.57418840773 36745.61342408703 50446.77463985902 27602.354138177187 1.3333034703138549 1.2451950504849907 1.0873081669580436 1.2815044390864332 1.1589180062618651 1.2305514718902761 1.582168461783663 1.3312492564995997 1.8276258027602583 1.0 14.752503695778923 -7.203565382867384 9.340603570056594 1.4627218751586215 1.2171133563386742 0.20110917373792225 0.2043670960028292 0.6562131099246213 102.64894117381458 0.07259281353069244 0.05615395553430991 6.257986430838937e-08 7.203565382867384 -0.24560851881994727 S(ph)TPLEENVVDREQIDFLAAR ddPTM_A459_Selumetinib_30min_R1 2 STPLEENVVDREQIDFLAAR 20 1 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 S(0.803)T(0.197)PLEENVVDREQIDFLAAR;S(0.755)T(0.245)PLEENVVDREQIDFLAAR 79.029 0.0025606 12489800.0 1633.85 1614.24 1875.31 1834.0 1574.87 1526.24 1551.37 1655.92 1005.13 1220.13 True False 1671.9155260813206 1425.2440303601838 1620.6532023404768 1513.7263284437745 1432.4232865658812 1510.8874113150434 1434.3489118848465 1611.9996224137815 1705.6321982093643 1376.7455705726431 1.2143968804533032 1.0352268863791356 1.1771624597756163 1.099496058530376 1.0404415435817087 1.0974340093112522 1.0418402227277506 1.1708769266228958 1.2388870061880237 1.0 10.427046251550616 -9.639915584155695 11.48798589304871 1.0000053523031844 1.117934237871734 0.21385767861594251 0.07045684693227426 0.0 0.0 0.06812310332624526 0.016522279444645592 2.2913129826786983e-10 9.639915584155695 0.11792888556854964 S(ph)TPLSQPSANGVQTEGLDYDR ddPTM_A459_Selumetinib_30min_R1 3 STPLSQPSANGVQTEGLDYDR 21 0 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 S(0.862)T(0.138)PLSQPSANGVQTEGLDYDR;S(0.834)T(0.162)PLS(0.004)QPSANGVQTEGLDYDR;S(0.857)T(0.143)PLSQPSANGVQTEGLDYDR 340.33 5.891499999999996e-175 58112000.0 4099.22 3929.27 4101.450000000001 3815.1400000000003 4144.219999999999 4202.93 3210.46 3438.2400000000002 2228.99 2634.59 True False 4194.72385030638 3469.229241731937 3544.4956176521982 3148.8974180474283 3769.3760327214663 4160.652340155109 2968.2924174438244 3347.0467062225 3782.433231011599 2972.7652895797814 1.4110511398292496 1.1670040866974511 1.192322727285757 1.0592485821484225 1.267969605920113 1.3995899221304628 0.9984953833551423 1.1259034535806307 1.272361879449376 1.0 11.537589846486052 -14.522878745279307 0.105890761654342 0.38687629822595204 1.3211092359250418 0.22484813918605173 0.12456196534616423 301.7357156573693 2.137035393560781 40.88953832315745 1.8153812740807493 3.000000000007118e-15 14.522878745279307 0.9342329376990898 S(ph)TPLSQPSANGVQTEGLDYDR ddPTM_A459_Selumetinib_30min_R2 4 STPLSQPSANGVQTEGLDYDR 21 0 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 S(0.844)T(0.156)PLSQPSANGVQTEGLDYDR;S(0.836)T(0.163)PLS(0.001)QPSANGVQTEGLDYDR;S(0.768)T(0.175)PLS(0.057)QPSANGVQTEGLDYDR;S(0.881)T(0.119)PLSQPSANGVQTEGLDYDR 247.36 8.65e-39 97582300.0 44848.0 46337.1 59074.1 66927.2 66397.3 49415.5 56547.3 47897.7 40454.7 52598.7 True False 42355.52770076862 49891.00657274013 55273.336721016916 57811.59990414027 58055.87757460671 56222.03657575366 59176.86149634921 48037.074377108904 48546.77039876072 51080.038863165006 0.8291992066457132 0.9767221733403513 1.0820926912190703 1.131784571640754 1.1365668246676324 1.1006655011826285 1.1585124603149628 0.9404275221049126 0.9504059017811146 1.0 15.64047200223445 -4.870275952642191 2.4432869044080023 1.0699743223197078 0.7993795692012082 0.48761244512017343 0.07312268134157615 0.3940677680824395 3.446323840663657 0.021089502810208865 0.21025792180710512 1.3481060178429416e-05 4.870275952642191 -0.27059475311849956 S(ph)TPLSQPSANGVQTEGLDYDRLK ddPTM_A459_Selumetinib_30min_R1 1 STPLSQPSANGVQTEGLDYDRLK 23 1 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 S(0.523)T(0.18)PLS(0.009)QPS(0.288)ANGVQTEGLDYDRLK 71.265 0.0011587 5331000.0 799.33 629.09 1309.3 1327.1 951.45 753.91 720.64 642.94 594.26 614.93 True False 817.9528337745706 555.4358503439933 1131.5042514700963 1095.3468977523082 865.3915154921408 746.326349895511 666.2815446094072 625.8871426365511 1008.4158169668561 693.8622554254347 1.1788403640331337 0.8004987243519008 1.6307332509048584 1.5786229747872758 1.2472093830230535 1.0756116852586375 0.9602504523046629 0.9020337073282573 1.4533371848401757 1.0 9.438505479179877 -6.718101124907497 4.660017165219632 1.0636124250383956 1.2989872323320564 0.14513685590561598 0.2538986951178197 0.4159388404191197 19.808231438171756 0.09288728538817476 0.09011389857270605 1.9138102448988346e-07 6.718101124907497 0.23537480729366078 S(ph)TPPPNNLVNPVQELETER ddPTM_A459_Selumetinib_30min_R1 2 STPPPNNLVNPVQELETER 19 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 S(0.841)T(0.159)PPPNNLVNPVQELETER;S(0.5)T(0.5)PPPNNLVNPVQELETER 157.84 2.6922e-06 30867000.0 3843.87 4540.0 4126.17 4010.8 4319.24 3391.83 3467.1099999999997 3383.6000000000004 2013.47 2996.29 True False 3933.424692130984 4008.454689411262 3565.858777429439 3310.389072040507 3928.5655046237575 3357.7112697352354 3205.5831013137245 3293.855936518233 3416.711531969602 3380.893007836137 1.1634277343335637 1.18562009508156 1.0547091461234042 0.979146357003248 1.1619904846199631 0.993143309165013 0.9481468635310009 0.9742561887891242 1.010594397412295 1.0 11.723188645907694 -4.52674845048836 0.4467642173734131 0.980984078973621 1.3901430237490935 0.5570920484499816 0.05653170823435695 4.86098381038671 0.637288657342604 0.04204729575845212 1.1065442571471722 2.9733877613464256e-05 4.52674845048836 0.40915894477547243 S(ph)TPPPNNLVNPVQELETER ddPTM_A459_Selumetinib_30min_R2 3 STPPPNNLVNPVQELETER 19 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 S(0.816)T(0.184)PPPNNLVNPVQELETER;S(0.5)T(0.5)PPPNNLVNPVQELETER;S(0.817)T(0.183)PPPNNLVNPVQELETER 111.09 0.00062822 24822800.0 103703.0 96085.0 107823.8 120924.0 116038.0 91584.0 114808.0 104769.0 87734.6 110326.0 True False 97939.6024160008 103454.4105380296 100886.53409767714 104453.94259446459 101460.26904711808 104198.86468322325 120146.7994877363 105073.8604445583 105283.9715095433 107140.60171862697 0.9141221987273332 0.965594824730609 0.941627473426234 0.9749239869753756 0.9469824456798684 0.9725432096869371 1.1213937345924774 0.980710008708964 0.9826710865974082 1.0 16.70914577803412 -7.015457582638256 24.94187065268251 1.0234979613899289 0.9515712271131335 0.42380993195961325 0.039871991125566844 674.6629077884677 1088613.0928555478 0.014875619021550117 0.011907016611003407 9.650335616301528e-08 7.015457582638256 -0.07192673427679541 S(ph)TPPPNNLVNPVQELETERR ddPTM_A459_Selumetinib_30min_R2 2 STPPPNNLVNPVQELETERR 20 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 S(0.951)T(0.049)PPPNNLVNPVQELETERR;S(0.76)T(0.24)PPPNNLVNPVQELETERR 87.06200000000003 0.0011193 7818500.0 13087.8 14028.7 14629.4 22192.6 14811.3 14198.9 10737.1 15011.4 10312.2 13947.0 True False 12360.432470614509 15104.656180619833 13688.160331286384 19169.92959562965 12950.57207929798 16154.669590219024 11236.396425160028 15055.080688728944 12374.92814694215 13544.313871342114 0.9125919989765939 1.1152027577106867 1.0106204316667993 1.4153488894103787 0.9561630217902429 1.1927270545907873 0.82960248351411 1.111542513835522 0.9136622397038345 1.0 13.725399690809253 -7.245786247247459 24.893535522684232 0.9729970007505248 1.1047862466983254 0.17043281387176146 0.14703488770897385 1430.8222698187624 2275472.3753714617 0.054351467338485684 0.04195486361247098 5.678240104804611e-08 7.245786247247459 0.13178924594780062 S(ph)TPPYLFPEYPEASK ddPTM_A459_Selumetinib_30min_R1 2 STPPYLFPEYPEASK 15 0 Q8TE76-2;Q8TE76-3;Q8TE76 Q8TE76-2 MORC4 MORC family CW-type zinc finger protein 4 1 S(0.553)T(0.447)PPYLFPEYPEASK;S(0.5)T(0.5)PPYLFPEYPEASK 111.52 0.003233 17365200.0 5460.2 5974.799999999999 4644.4 4593.1 5384.1 4241.4 5908.7 5700.0 2748.7 5747.0 True False 5587.4120363002885 5275.267638390835 4013.7159898630653 3791.0013081652714 4897.109105640064 4198.735366883077 5463.002001878339 5548.817483790616 4664.343142895025 6484.683430520504 0.8616321978036491 0.8134965561406606 0.6189532662415408 0.5846085393039735 0.7551809056077529 0.6474850178686454 0.8424469845615643 0.855680549905461 0.719286175319222 1.0 12.662820431326278 -7.280338634467444 23.4208393158778 0.8423268534930222 0.7098322192662818 0.3111685913044454 0.10190747226568736 520.2094779961806 644663.3201881892 0.04410859831423752 0.029810149611631833 5.2439840917079925e-08 7.280338634467444 -0.13249463422674035 S(ph)TPPYLFPEYPEASK ddPTM_A459_Selumetinib_30min_R2 2 STPPYLFPEYPEASK 15 0 Q8TE76-2;Q8TE76-3;Q8TE76 Q8TE76-2 MORC4 MORC family CW-type zinc finger protein 4 1 S(0.492)T(0.492)PPY(0.016)LFPEYPEASK;S(0.5)T(0.5)PPYLFPEYPEASK 141.0 0.00038722 15956100.0 28353.0 23185.1 32619.0 33196.0 28050.0 23625.4 28913.0 25597.0 23592.6 21052.0 True False 26777.25376605183 24963.322618153423 30520.329052881905 28674.647533705895 24526.10822981834 26879.58439997189 30257.51179002262 25671.483032188524 28311.779232321627 20444.17406033515 1.3097742998580622 1.221048233324628 1.4928619254957356 1.402582831132275 1.199662464105252 1.3147796688017066 1.4800065632745154 1.2556869725539639 1.38483360339075 1.0 14.319402159061907 -10.809959348052418 3.4467165083090356 0.9988272902159588 1.339715833842123 0.5325368315912533 0.09560292374416249 35665330.32949353 56119009.89408098 444482.37570605805 0.024070765969629336 1.5489616020092195e-11 10.809959348052418 0.34088854362616405 S(ph)TPQPPSGK ddPTM_A459_Selumetinib_30min_R1 2 STPQPPSGK 9 0 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 S(0.891)T(0.109)PQPPSGK;S(0.855)T(0.145)PQPPSGK 118.23 0.0072794 25600000.0 10507.2 12273.5 10603.9 9806.7 11019.1 9765.7 11376.3 10835.599999999999 6211.200000000001 9916.9 True False 10751.997316547828 10836.512914204653 9163.948623053344 8094.143939558107 10022.424350580119 9667.46592454615 10518.176531888328 10548.20468901081 10539.952751900753 11189.830713786116 0.9608722054482141 0.9684250987688163 0.8189532851254987 0.7233482030774554 0.8956725626092157 0.8639510437486441 0.939976376848106 0.9426598988682815 0.9419224491855182 1.0 13.449900590106056 -7.353687958939603 2.594933209008501 0.9567132219779086 0.8673009579631925 0.2737385739347403 0.0672891856788362 0.46380092699257897 6.091417446659485 0.03662839591024203 0.022832679907999275 4.4290648686151496e-08 7.353687958939603 -0.08941226401471614 S(ph)TPSPTPVESSDPK ddPTM_A459_Selumetinib_30min_R1 1 STPSPTPVESSDPK 14 0 Q9NW07 Q9NW07 ZNF358 Zinc finger protein 358 1 S(0.482)T(0.037)PS(0.469)PT(0.012)PVESSDPK 169.04 0.00018506 14906000.0 3353.9 3983.7 4800.0 4301.7 3215.8 3137.5 3981.8 3442.1 1931.7 3389.4 True False 3432.0393444466395 3517.2865520281166 4148.186364512687 3550.4888479098095 2924.9314577956015 3105.939598622072 3681.4496202344285 3350.8043264834523 3277.953814214108 3824.462505551798 0.897391290793021 0.9196812746685925 1.0846455831351343 0.9283628334061914 0.7647954329659689 0.8121244734687085 0.9626057556820692 0.8761503927987899 0.8571018305070718 1.0 11.901041288660046 -6.005637345552768 24.99375427932354 0.8710169308059822 0.9698203428784171 0.20406495234976052 0.07806483530426822 369.39969990156294 1637787.8134415674 0.022664195731577668 0.032476570288698575 9.871034150998976e-07 6.005637345552768 0.09880341207243493 S(ph)TPSSSTPSSR ddPTM_A459_Selumetinib_30min_R2 3 STPSSSTPSSR 11 0 H3BUV9;Q96S82 H3BUV9 UBL7 Ubiquitin-like protein 7 1 S(0.5)T(0.5)PSSSTPSSR;S(0.981)T(0.019)PSSSTPSSR;S(0.972)T(0.028)PSSSTPSSR 141.71 0.00098144 5769300.0 41953.0 33274.2 38371.0 47606.0 47010.0 42960.0 60615.0 53586.0 54781.0 47690.0 True False 39621.420211165365 35826.22414658382 35902.251635185974 41121.9806750694 41104.183525267734 48877.35004794801 63433.71760634388 53741.926388360145 65738.730709028 46313.06578649932 0.8555127918721237 0.7735662396383073 0.7752078387704536 0.887913161798432 0.8875288825567229 1.0553684844201396 1.3696721762875692 1.160405286838653 1.41944243147452 1.0 15.499131641850854 -6.8885695174408195 2.3103078588780663 1.2514070474921888 0.8226685711371967 0.7352245793736439 0.11342243104258184 0.13979404350323313 1.5202040810971706 0.04306396323176909 0.03665216306776185 1.292499794034267e-07 6.8885695174408195 -0.42873847635499207 S(ph)TPVIVSATTK ddPTM_A459_Selumetinib_30min_R2 2 STPVIVSATTK 11 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.952)T(0.048)PVIVSATTK;S(0.905)T(0.095)PVIVSATTK 125.36 0.0033649 16579600.0 141753.0 153962.0 170955.0 184374.0 180989.0 137665.0 163789.0 155648.0 123033.0 166014.0 True False 133874.93574221936 165770.39033414255 159955.9414217306 159261.94313710986 158251.54375781072 156627.1041515542 171405.5130417465 156100.90991108643 147643.0378292442 161220.74446382688 0.8303828157316125 1.0282199780521202 0.9921548368586024 0.9878501905370093 0.9815830108222683 0.9715071386901867 1.0631728169460524 0.9682433264418452 0.9157818884924631 1.0 17.29867786352338 -4.75304459847177 24.998909947195042 0.9903140909365017 0.8303825179908202 0.6320368206305995 0.03649744567433036 209.67555863862873 624347.3201130664 0.009166420369327667 0.10294249804224348 1.7658564724370483e-05 4.75304459847177 -0.1599315729456815 S(ph)TQGVTLTDLQEAEK ddPTM_A459_Selumetinib_30min_R2 2 STQGVTLTDLQEAEK 15 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 S(0.974)T(0.026)QGVTLTDLQEAEK;S(0.907)T(0.092)QGVTLTDLQEAEK 185.23 2.1294e-05 5983000.0 20590.0 26148.0 25137.0 20057.1 20351.0 16550.2 20867.4 20303.0 19445.6 18360.8 True False 19445.6902283006 28153.46752092835 23519.712787096247 17325.288379572634 17794.32543975163 18829.839822242768 21837.77544796866 20362.078368657414 23335.263355460338 17830.67599691249 1.0905750422287837 1.5789343895768913 1.31905895161624 0.9716562839553942 0.9979613472216557 1.0560362279872781 1.2247306524862 1.1419689512715756 1.308714451403918 1.0 14.122073779029805 -5.635284490453697 7.002596209201186 1.1058000333510325 1.3620906511797508 0.3297506945722679 0.1486299326232183 0.23160518538172783 13.28137683202955 0.04038566323066636 0.07030716982303392 2.315877106467606e-06 5.635284490453697 0.2562906178287183 S(ph)TSATDTHHVEMAR ddPTM_A459_Selumetinib_30min_R1 5 STSATDTHHVEMAR 14 0 H3BQP2;H3BNP3;H3BTL2;H3BS02;O14874-2;O14874-3;O14874 H3BQP2 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 1 S(0.773)T(0.159)S(0.054)AT(0.014)DTHHVEMAR;S(0.85)T(0.149)S(0.001)ATDTHHVEMAR;S(0.98)T(0.02)SATDTHHVEMAR;S(0.848)T(0.149)S(0.003)ATDTHHVEMAR;S(0.97)T(0.022)S(0.007)ATDT(0.001)HHVEMAR 197.73 5.9908e-05 101584000.0 5969.56 7036.7 6654.74 7944.7 7151.48 7059.66 6964.179999999999 5821.11 2536.62 4637.38 True False 6108.639133258265 6212.839892726921 5751.062859870237 6557.307285489237 6504.629896696343 6988.646230058417 6438.866295706511 5666.715253169896 4304.458872605369 5232.632894906414 1.1674121338044907 1.1873257722273365 1.0990763111756754 1.2531563779053365 1.2430892874270094 1.335588865188948 1.230521312124586 1.0829567766326642 0.8226181654737227 1.0 12.353321332210964 -8.009746702236892 3.7477922349142356 0.9146565531263112 1.2167635312914025 0.7466992103344664 0.07083431333386372 0.11464095592356358 3.4671303332584205 0.05205213796502024 0.019899560949191774 9.778073506988454e-09 8.009746702236892 0.30210697816509124 S(ph)TSATDTHHVEMAR ddPTM_A459_Selumetinib_30min_R2 1 STSATDTHHVEMAR 14 0 H3BQP2;H3BNP3;H3BTL2;H3BS02;O14874-2;O14874-3;O14874 H3BQP2 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 1 S(0.837)T(0.158)S(0.005)ATDTHHVEMAR 110.84 0.002148 8455500.0 15557.0 8555.0 16555.0 18833.0 15220.0 12224.0 19216.0 18325.0 15248.0 11501.0 True False 14692.40421960527 9211.14099133937 15489.869323721137 16267.9129112629 13307.927531473626 13907.745041576269 20109.582075781647 18378.322716132934 18298.026064716913 11168.93624681335 1.315470327247791 0.8247106785990864 1.3868706008721832 1.4565319876281286 1.1915125341744663 1.2452166199394628 1.8004921535405116 1.6454855064085911 1.6382962226987006 1.0 13.447204166576812 -7.181428782020489 9.608559653055828 1.574614855368006 1.2321719154873345 0.2220736654179416 0.2528430260017832 0.5934638340981248 68.1916324287918 0.0947791654670443 0.07339174173863929 6.585234093524843e-08 7.181428782020489 -0.3424429398806714 S(ph)TSEGAWPQLPSGLSMMR ddPTM_A459_Selumetinib_30min_R1 1 STSEGAWPQLPSGLSMMR 18 0 G3V1A6;P57764 G3V1A6 GSDMD Gasdermin-D 1 S(0.333)T(0.333)S(0.333)EGAWPQLPSGLSMMR 247.44 8.637899999999998e-33 40187000.0 995.89 1242.8 1634.1 1552.3 1175.1 902.23 1229.2 1144.8 689.34 1117.7 True False 1019.0922993353906 1097.292398237955 1412.198195468787 1281.2199452798648 1068.8124124807548 893.1543853592962 1136.4804543654027 1114.4361851655258 1169.7596325984125 1261.1676823199532 0.8080545621504841 0.8700606696640489 1.119754506292937 1.0158997595966184 0.8474784340450625 0.708196378546835 0.9011335053200976 0.8836542521574049 0.9275210973108722 1.0 10.300544390913865 -5.000735472681552 24.891540527282416 0.9185697028602512 0.8235559834475475 0.10948932814707435 0.10379489084805839 73.28203945151961 2481052.0566088515 0.028603310393130594 0.10569533393365263 9.98307944709572e-06 5.000735472681552 -0.09501371941270365 S(ph)TSFRGGMGSGGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R1 7 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.314)T(0.314)S(0.314)FRGGMGS(0.028)GGLAT(0.029)GIAGGLAGMGGIQNEK;S(0.332)T(0.332)S(0.302)FRGGMGS(0.016)GGLAT(0.019)GIAGGLAGMGGIQNEK;S(0.32)T(0.32)S(0.287)FRGGMGS(0.067)GGLAT(0.006)GIAGGLAGMGGIQNEK;S(0.324)T(0.324)S(0.324)FRGGMGS(0.022)GGLAT(0.005)GIAGGLAGMGGIQNEK;S(0.426)T(0.136)S(0.426)FRGGMGS(0.011)GGLATGIAGGLAGMGGIQNEK;S(0.323)T(0.323)S(0.323)FRGGMGS(0.021)GGLAT(0.011)GIAGGLAGMGGIQNEK;S(0.319)T(0.319)S(0.319)FRGGMGS(0.01)GGLAT(0.032)GIAGGLAGMGGIQNEK 120.27 8.142999999999999e-16 682927000.0 6529.9400000000005 6191.7300000000005 10027.769999999999 12850.59 9455.47 6445.359999999999 5686.450000000001 5366.139999999999 3272.2 4085.77 True False 6682.0748969486 5466.79937314282 8666.05391259779 10606.475691949996 8600.224407998816 6380.525530318645 5257.516498312838 5223.81253552073 5552.684407967803 4610.21837827001 1.4494052881408312 1.1858005249621695 1.8797491141514509 2.300644963358566 1.8654700715557122 1.3839963764824834 1.14040508863828 1.13309438011502 1.2044298018809803 1.0 12.170619374966439 -6.974344761153077 3.602859656099289 1.13820038651156 1.7428795597304994 0.5233542074464854 0.2773596577593397 0.22455072727833433 6.233517842340555 0.12242140978681525 0.10210634099945447 1.060853073232945e-07 6.974344761153077 0.6046791732189394 S(ph)TSFRGGMGSGGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R2 6 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.303)T(0.303)S(0.303)FRGGMGS(0.041)GGLAT(0.05)GIAGGLAGMGGIQNEK;S(0.204)T(0.202)S(0.202)FRGGMGS(0.182)GGLAT(0.21)GIAGGLAGMGGIQNEK;S(0.426)T(0.144)S(0.426)FRGGMGS(0.003)GGLATGIAGGLAGMGGIQNEK;S(0.303)T(0.158)S(0.303)FRGGMGS(0.033)GGLAT(0.203)GIAGGLAGMGGIQNEK;S(0.587)T(0.129)S(0.129)FRGGMGS(0.063)GGLAT(0.093)GIAGGLAGMGGIQNEK;S(0.315)T(0.315)S(0.315)FRGGMGS(0.024)GGLAT(0.03)GIAGGLAGMGGIQNEK 105.42 2.8714e-11 418912900.0 248166.7 385444.2 399974.9 339736.1 352636.7 163969.2 99385.43999999999 100760.79999999999 66497.78 357001.6 True False 234374.58830401185 415006.5307415568 374240.95039374364 293463.45710253826 308335.3251339033 186554.468935801 104007.05988851326 101053.99724615157 79799.19410321432 346694.0362064475 0.6760271704369547 1.1970397162944877 1.0794559793664655 0.8464623744718476 0.8893586071099805 0.5380954082080389 0.2999966801464669 0.29147890270017934 0.23017181078850726 1.0 18.403303494105955 -6.787638126472114 2.451918417856162 0.39462513424953793 0.9713071277289931 0.4790254015029177 0.240748854559633 0.21566957702887332 2.657544279933834 0.08907489521096201 0.08107297315717528 1.6306542005102632e-07 6.787638126472114 0.5766819934794551 S(ph)TSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR ddPTM_A459_Selumetinib_30min_R1 3 STSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR 40 2 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.291)T(0.291)S(0.291)FRGGMGS(0.115)GGLAT(0.013)GIAGGLAGMGGIQNEKETMQSLNDR;S(0.305)T(0.305)S(0.305)FRGGMGS(0.085)GGLAT(0.001)GIAGGLAGMGGIQNEKETMQSLNDR;S(0.322)T(0.322)S(0.322)FRGGMGS(0.034)GGLATGIAGGLAGMGGIQNEKETMQSLNDR 75.755 5.8627e-09 370471000.0 1574.2399999999998 970.7 6386.6 8442.099999999999 3609.2999999999997 1729.62 1317.4 1296.29 1196.06 791.6 True False 1610.916729062191 857.0499927338126 5519.334799082652 6967.845712843616 3282.839452273669 1712.2215931693097 1218.0274573551749 1261.9081782566552 2029.626463233901 893.2095708369637 1.8035148543613506 0.9595172518479974 6.179215918959391 7.800908029136475 3.675329462936175 1.9169315344045268 1.36365249222962 1.4127795082560637 2.272284724101289 1.0 9.802854899651019 -6.740430320177389 4.203270486752069 1.5742911945910256 4.27215424603603 0.31445272874073726 1.8485567647670396 0.29165087796126016 11.645791110518118 0.7310772738239967 0.6949471749641678 1.8178987031304204e-07 6.740430320177389 2.6978630514450046 S(ph)TSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR ddPTM_A459_Selumetinib_30min_R2 1 STSFRGGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR 40 2 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.321)T(0.321)S(0.321)FRGGMGS(0.033)GGLAT(0.004)GIAGGLAGMGGIQNEKETMQSLNDR 50.398 0.0012528 3979500.0 3231.6 9900.1 5658.4 9498.0 5701.1 2480.5 819.25 2113.0 961.47 6819.1 True False 3052.0006091197774 10659.405836161188 5294.3447044001 8204.356015036106 4984.876849519337 2822.166359262922 857.3467483130784 2119.1484801740194 1153.7908657163812 6622.21486485044 0.46087308723841985 1.6096436092310222 0.7994824711142428 1.2389141975116809 0.7527506961421915 0.4261665344388761 0.12946525683781798 0.32000599850996825 0.17423035785813923 1.0 12.693098105941434 -6.6217944310737815 2.849589195925832 0.3434003461709467 1.0515364887417076 0.39279057023098296 0.3569449212470363 0.23032177297119072 3.7800732679265305 0.11830805204142361 0.11889163666345252 2.388941796912335e-07 6.6217944310737815 0.7081361425707609 S(ph)TSPFGIPEEASEMLEAKPK ddPTM_A459_Selumetinib_30min_R1 1 STSPFGIPEEASEMLEAKPK 20 1 Q96D09 Q96D09 GPRASP2 G-protein coupled receptor-associated sorting protein 2 1 S(0.355)T(0.355)S(0.29)PFGIPEEASEMLEAKPK 112.85 0.00017451 105420000.0 2546.1 3023.6 2970.8 3355.3 2674.3 2795.4 2931.8 2488.1 1189.2 2348.5 True False 2605.4191761518205 2669.595506366494 2567.381677436308 2769.359841781571 2432.4100371860145 2767.280814020125 2710.65196559428 2422.107505512181 2017.9855442684782 2649.9528513271957 0.9831945405545344 1.0074124545383745 0.9688405120681551 1.0450600433870254 0.9179069114259042 1.0442754906503966 1.0229057336762364 0.9140190944526045 0.761517527852541 1.0 11.371750975748656 -7.923785771829671 5.091224840841017 0.8674446189160225 0.9975645407403685 0.3674077486837526 0.06442679988680149 0.17666417328336934 8.135059024744576 0.03447470257657955 0.015844101967530607 1.1918297671598097e-08 7.923785771829671 0.13011992182434595 S(ph)TSPFGIPEEASEMLEAKPK ddPTM_A459_Selumetinib_30min_R2 1 STSPFGIPEEASEMLEAKPK 20 1 Q96D09 Q96D09 GPRASP2 G-protein coupled receptor-associated sorting protein 2 1 S(0.333)T(0.333)S(0.333)PFGIPEEASEMLEAKPK 64.331 0.0099908 20200000.0 47958.0 44161.0 47741.0 49897.0 39965.0 39009.0 39841.0 42388.0 30784.0 44102.0 True False 45292.686351085016 47548.006700004444 44669.39603647058 43100.94252287398 34944.23940836685 44382.135661555025 41693.6854434438 42511.34206228882 36941.66017682619 42828.66066924287 1.0575321675564717 1.1101913054720094 1.04297905511086 1.0063574683255656 0.8159078257953052 1.0362718555293926 0.9734996330012686 0.9925909752489196 0.8625453049330494 1.0 15.386288941764313 -5.808470248923759 3.015571665727446 0.9500482351800342 1.0791357820316239 0.4249515648921117 0.06396607252497542 0.23644126771509238 4.375787527005198 0.01837828985695721 0.031007301317422596 1.5542817622403628e-06 5.808470248923759 0.12908754685158963 S(ph)TSPIIGSPPVR ddPTM_A459_Selumetinib_30min_R1 1 STSPIIGSPPVR 12 0 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 S(0.984)T(0.008)S(0.008)PIIGSPPVR 125.97 0.0028012 67210000.0 2969.6 4375.5 3078.6 3250.5 3775.9 3192.0 3967.0 3598.4 1871.3 3323.4 True False 3038.785902164269 3863.2144258852345 2660.5430295393226 2682.8611944419254 3434.37051168929 3159.89137810411 3667.7659961499776 3502.9587427495007 3175.4594256555683 3749.99076265736 0.8103449033594128 1.030193051235049 0.709479888866174 0.7154314141672089 0.9158343924174333 0.8426397764950527 0.9780733415862829 0.9341246324210131 0.8467912660684367 1.0 11.872671326487984 -6.908112436317627 1.9614816947206013 0.9317975092756539 0.8292149564812998 0.20814954296237287 0.09512392336108275 0.6111827452492399 4.796383090068533 0.04247470221679904 0.035124216775956424 1.2356274952530868e-07 6.908112436317627 -0.10258255279435402 S(ph)TSPPPS(ph)PEVWADSR ddPTM_A459_Selumetinib_30min_R1 1 STSPPPSPEVWADSR 15 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;E5RFK4;E5RJ61;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 2 S(0.848)T(0.131)S(0.021)PPPS(1)PEVWADSR 155.2 0.0031666 4835400.0 1670.8 2313.9 2155.1 2699.9 2362.4 2087.3 2834.3 2581.6 1483.6 1903.7 True False 1709.7263891891366 2042.987512297075 1862.4492571169346 2228.413148399863 2148.721337115595 2066.303657116765 2620.506469091978 2513.1275817813794 2517.560842143216 2148.058438608297 0.7959403517424085 0.9510856295048955 0.867038449067333 1.0374080650448352 1.0003086035721298 0.9619401502202612 1.2199418889133087 1.1699530779104905 1.1720169232333901 1.0 11.068817527493582 -6.279187065016671 0.7121077780085945 1.1465754796576961 0.8488044703371734 0.6024170895289652 0.08180616453919916 0.5242910430602175 0.5730613746917306 0.05042689222041076 0.08924301910275449 5.257907421222623e-07 6.279187065016671 -0.2977710093205227 S(ph)TSPPPS(ph)PEVWADSR ddPTM_A459_Selumetinib_30min_R2 1 STSPPPSPEVWADSR 15 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;E5RFK4;E5RJ61;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 2 S(0.666)T(0.302)S(0.031)PPPS(1)PEVWADSR 128.82 0.01705 5255500.0 13883.0 15401.0 16989.0 16757.0 18013.0 9849.9 11638.0 15522.0 12217.0 16867.0 True False 13111.438438052322 16582.207177979868 15895.946236224601 14474.667692562649 15750.045901736832 11206.634316510317 12179.190060259503 15567.166450194563 14660.741371500955 16380.005884270997 0.800453829546097 1.0123443968907873 0.9704481395509621 0.8836790288617685 0.961540918423046 0.6841654634124129 0.7435400296134599 0.9503761207523761 0.8950388342399207 1.0 13.99964825479498 -4.484618757060823 17.098553787719187 0.8914694638024957 0.3899937388700345 0.07238416211159182 0.10292655562491192 1116779.3864088904 14134076.833120005 0.027394554674229916 17536531.60526955 3.27628175207821e-05 4.484618757060823 -0.5014757249324612 S(ph)TSPPPSPEVWADSR ddPTM_A459_Selumetinib_30min_R1 3 STSPPPSPEVWADSR 15 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;E5RFK4;E5RJ61;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 S(0.333)T(0.333)S(0.333)PPPSPEVWADSR;S(0.469)T(0.469)S(0.063)PPPSPEVWADSR;S(0.333)T(0.333)S(0.333)PPPSPEVWADSR 127.3 0.0010685 95769000.0 10991.9 13007.2 13552.5 14499.8 14291.9 11014.8 11381.6 9865.2 5312.9 11237.400000000001 True False 11247.989883485805 11484.310977116771 11712.144938553793 11967.682124955865 12999.20016843989 10904.001112638216 10523.076748621274 9603.542849314244 9015.60326113689 12679.82975154535 0.8870773585989954 0.905714919060102 0.923683138342325 0.9438361838807265 1.025187279573341 0.8599485423934256 0.8299067854076493 0.7573873654055817 0.7110192674344161 1.0 13.63024775450231 -6.980116015737116 7.001613267284856 0.8097215726376362 0.9359930328468741 0.3151828478451385 0.07784223175376889 0.17560721496564172 36.52160295177195 0.027657536179997777 0.023900514270322883 1.0468488595663255e-07 6.980116015737116 0.12627146020923785 S(ph)TSPSAAGGQQK ddPTM_A459_Selumetinib_30min_R2 1 STSPSAAGGQQK 12 0 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 S(0.743)T(0.073)S(0.183)PSAAGGQQK 144.28 0.00075559 6187700.0 34350.0 21499.0 27324.0 31198.0 26766.0 33233.0 69534.0 118640.0 49702.0 64739.0 True False 32440.96451394492 23147.904169819427 25566.003588121795 26948.778580448157 23403.415788923998 37810.54409086261 72767.46877900716 118985.2227580908 59643.788789910854 62869.816857877515 0.5160022111608888 0.3681878733979328 0.40664988170580946 0.4286441400229959 0.37225201151499104 0.6014101198407578 1.1574309011191193 1.8925651243277335 0.948687172490746 1.0 15.940079940047454 -7.25131002463529 3.1622912775926384 1.3469714323160957 0.4225576318890534 0.7196522795110989 0.24586398025021594 0.12010349540262216 2.478739840551981 0.10188023051185321 0.07059239521432047 5.606476103073867e-08 7.25131002463529 -0.9244138004270424 S(ph)TSSHGTDEMESSSYR ddPTM_A459_Selumetinib_30min_R2 1 STSSHGTDEMESSSYR 16 0 A0A0D9SGE8;Q5JRC6;Q8IWS0-2;Q8IWS0-3;Q8IWS0-4;Q8IWS0-5;Q8IWS0 A0A0D9SGE8;Q8IWS0-5 PHF6 PHD finger protein 6 1 S(0.454)T(0.454)S(0.087)S(0.005)HGTDEMESSSYR 94.61 0.010521 0.0 9657.9 7964.5 8855.5 9061.4 11684.0 8031.2 6765.0 7600.3 6515.9 5495.3 True False 9121.15258163693 8575.351540096133 8285.746771139386 7827.221688213117 10216.151463714716 9137.424900025146 7079.585904593193 7622.415614702602 7819.262069457564 5336.636410495901 1.7091575816740636 1.6068832276507439 1.5526159426644248 1.4666957023376792 1.914342795327402 1.7122067529378604 1.3266007574863676 1.428318331695057 1.4652041975501509 1.0 12.381715007316206 -8.752279474184201 0.5501957167816828 0.9894177657453356 1.6504930621189153 0.6403754607186092 0.14176773687532912 0.8570538050089976 0.5588064918134354 0.1838963980364976 0.07400168358382614 1.7689702364617845e-09 8.752279474184201 0.6610752963735798 S(ph)TSTPNVHMVSTTLPVDSR ddPTM_A459_Selumetinib_30min_R1 1 STSTPNVHMVSTTLPVDSR 19 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 S(0.432)T(0.432)S(0.109)T(0.028)PNVHMVSTTLPVDSR 118.59 0.00029787 50336000.0 1708.3 1705.4 2277.3 2511.7 2479.1 1844.2 1741.2 1899.0 877.98 1329.4 True False 1748.1000662268395 1505.7309751810485 1968.0551683134881 2073.078745448325 2254.8658427206547 1825.6490223996254 1609.859882151838 1848.6323511786634 1489.8679348779333 1500.0414394525758 1.1653678493474087 1.0037929190346562 1.3120005331530769 1.3820143170210506 1.5032023672249641 1.2170657252414818 1.0732102726037618 1.2323875211429507 0.9932178509826001 1.0 10.550786641161197 -7.978904393393432 1.1422975016988484 0.9967830008594651 1.2617978644285412 0.32826531096985245 0.13618341875256382 0.6639371268326447 1.5759474915393772 0.13893469990695428 0.049413276536118496 1.0497735028195932e-08 7.978904393393432 0.2650148635690761 S(ph)TSTPNVHMVSTTLPVDSR ddPTM_A459_Selumetinib_30min_R2 4 STSTPNVHMVSTTLPVDSR 19 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 S(0.427)T(0.427)S(0.114)T(0.031)PNVHMVSTTLPVDSR;S(0.431)T(0.431)S(0.109)T(0.029)PNVHMVSTTLPVDSR;S(0.386)T(0.386)S(0.131)T(0.097)PNVHMVSTTLPVDSR;S(0.42)T(0.42)S(0.124)T(0.037)PNVHMVSTTLPVDSR 101.92 0.00075254 218816500.0 91061.0 89534.0 123128.0 125121.0 124532.0 101551.0 98019.0 102148.0 95408.8 116428.0 True False 86000.19416606518 96400.96990281445 115206.07853163031 108079.30395423579 108887.17682979452 115538.72846180559 102577.0777209639 102445.23376848827 114493.22594460657 113066.42112372692 0.7606165766223062 0.8526047693445987 1.018923897887968 0.9558921462276249 0.9630372638277892 1.0218659732350885 0.9072284830587795 0.9060624078335685 1.0126191738157018 1.0 16.786811010562822 -5.0247927097044265 3.5684592405297106 0.9679152338993023 0.7694012080532844 0.741025294503546 0.04091146276375485 0.11389541176707467 2.990441580362458 0.010784205477680758 0.0435564266457983 9.445115874428674e-06 5.0247927097044265 -0.19851402584601796 S(ph)TSTPTSPGPR ddPTM_A459_Selumetinib_30min_R2 1 STSTPTSPGPR 11 0 H3BUF6;H3BRB0;A0A0C4DGL7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 S(0.573)T(0.054)S(0.014)T(0.344)PT(0.014)SPGPR 125.23 0.0034254 0.0 35293.0 34532.0 39349.0 38741.0 45808.0 36519.0 27099.0 29507.0 29715.0 37924.0 True False 33331.556349073 37180.49336211938 36817.32817995186 33464.40896804736 40053.1895112841 41549.160763524524 28359.15719564982 29592.860484853187 35658.83030647059 36829.03558161456 0.9050347320447473 1.009542953676481 0.9996821148998931 0.9086420113795526 1.0875438055532216 1.1281631491937927 0.7700217165015042 0.8035198320432331 0.968226013614971 1.0 15.168555998349978 -8.537191724627068 23.32100986854806 1.0000000127403919 0.9534935230260141 0.01866529248475768 0.10689612038959201 6886.39718413901 11220429.50784372 0.11183543502854437 0.028875785059980504 2.9027409209756763e-09 8.537191724627068 -0.04650648971437776 S(ph)TTELDDYSTNK ddPTM_A459_Selumetinib_30min_R1 4 STTELDDYSTNK 12 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.997)T(0.003)TELDDYSTNK;S(0.993)T(0.007)TELDDYSTNK;S(0.983)T(0.016)TELDDYSTNK;S(0.983)T(0.017)T(0.001)ELDDYSTNK 237.32 3.6476999999999997e-13 39820300.0 10756.900000000001 12232.099999999999 10157.300000000001 10566.199999999999 11094.5 9439.6 12332.699999999999 11956.599999999999 6184.5 11134.2 True False 11007.514840716203 10799.960045450982 8777.994450055143 8721.011522138824 10091.00443389307 9344.646194471048 11402.43450988626 11639.472127489624 10494.644801991597 12563.383026292226 0.8761585010725254 0.8596378875697086 0.6986967150237202 0.6941610793754982 0.8032075765560084 0.7438001511945379 0.9075926831191589 0.9264600229994523 0.8353358948006884 1.0 13.616937380249526 -7.2718225744437754 23.115166964403386 0.9112188584560791 0.7764858643169265 0.5011525669570499 0.06733912812153524 242.3884608318891 539602.9514618379 0.02946069716039696 0.020147454916418752 5.347827935685754e-08 7.2718225744437754 -0.13473299413915263 S(ph)TTELDDYSTNK ddPTM_A459_Selumetinib_30min_R2 2 STTELDDYSTNK 12 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.999)T(0.001)TELDDYSTNK;S(0.961)T(0.039)TELDDYSTNK 194.86 0.00016483 39635000.0 116820.0 90467.0 114965.0 115374.0 110223.0 89221.0 101232.0 108287.0 78890.0 90385.0 True False 110327.6120675122 97405.52800274703 107568.27706442754 99659.86216874888 96375.80133387758 101510.38288240148 105939.48858740243 108602.09724212211 94670.20437077119 87775.35020156701 1.2569316079532151 1.1097139205832312 1.2254952764917273 1.1353969188375816 1.0979825328245405 1.1564793834407199 1.2069389452064088 1.2372733004508514 1.0785511439529534 1.0 16.42152822665726 -8.505759572512986 5.205910484923034 1.00018276379947 1.1733075500251446 0.5608154065222901 0.05140992740588399 0.11049331305734368 10.33033239644826 0.049598258978681815 0.012890714694595498 3.1206166941988266e-09 8.505759572512986 0.17312478622567462 S(ph)TTPPPAEPVSLPQEPPK ddPTM_A459_Selumetinib_30min_R2 1 STTPPPAEPVSLPQEPPK 18 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPK 96.455 0.0024832 5440000.0 52112.0 47267.0 48921.0 55377.0 63450.0 46399.0 41089.0 49321.0 41610.0 55064.0 True False 49215.82366086458 50892.22691264036 45773.476121157444 47834.55706934667 55478.843749803025 52790.041081814255 42999.71991630891 49464.515944468876 49933.1626805398 53474.15924654639 0.9203664789557803 0.9517162612692638 0.8559924413232117 0.8945359355497684 1.0374888456686882 0.9872065652948753 0.8041214770307218 0.9250171791651596 0.9337811642875846 1.0 15.706554274183837 -7.445148819177009 0.005865425852185765 1.8630143762830282 3.881467826290877e-05 0.059585792996963316 0.06351654762450853 18426.606103114762 77.72069379389234 12256.998518546847 12422.314365199782 3.5879896435995904e-08 7.445148819177009 -1.8629755616047654 S(ph)TTPPPAEPVSLPQEPPKPR ddPTM_A459_Selumetinib_30min_R1 3 STTPPPAEPVSLPQEPPKPR 20 1 Q9UN86-2 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPKPR;S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPKPR;S(0.453)T(0.094)T(0.453)PPPAEPVSLPQEPPKPR 198.47 7.2106e-16 2283451000.0 20394.3 26247.6 22014.9 22880.5 21834.0 21583.4 23329.9 20332.6 11986.779999999999 17959.2 True False 20869.447509600195 23174.51878982181 19025.397499189654 18884.850195178744 19859.1185551058 21366.290592159254 21570.106859989766 19793.3133984072 20340.690180227455 20264.43825742192 1.0298557129732766 1.1436052899879454 0.9388563974736155 0.9319207349980255 0.9799984733271514 1.0543736925119933 1.0644315221562897 0.976751151301114 1.003762844142872 1.0 14.306662563102757 -5.261746354569383 24.99999241731639 0.99492000123537 1.0867304994920945 0.3793826423354696 0.047544588223764346 29.005769911177143 2362513.708421319 0.013268123719612689 0.03075701395912985 5.473355355120171e-06 5.261746354569383 0.0918104982567245 S(ph)TTPPPAEPVSLPQEPPKPR ddPTM_A459_Selumetinib_30min_R2 5 STTPPPAEPVSLPQEPPKPR 20 1 Q9UN86-2 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPKPR;S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPKPR;S(0.447)T(0.106)T(0.447)PPPAEPVSLPQEPPKPR;S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPKPR;S(0.333)T(0.333)T(0.333)PPPAEPVSLPQEPPKPR 151.2 6.5628e-06 90062100.0 395109.0 375871.0 389142.0 416278.0 397160.0 307003.0 347505.0 357304.0 283011.0 376053.0 True False 373150.4235266453 404699.097084246 364105.02738577465 359580.21828039637 347265.21014455106 349289.87655424065 363664.67106809455 358343.69548513857 339621.10798803705 365195.3727869659 1.0217829998199892 1.1081714809139278 0.9970143504478977 0.9846242451986238 0.9509025470241259 0.9564466107241626 0.9958085402145435 0.9812383238880077 0.9299710053723834 1.0 18.478308960187235 -5.451200560849866 4.651857025601319 0.971155107900531 1.0645877433225976 0.6341430476898817 0.028016100666484814 0.12378018724790397 5.018859902599767 0.007191832951311045 0.01528472855446003 3.5383389987172204e-06 5.451200560849866 0.0934326354220667 S(ph)TTPTSSPFR ddPTM_A459_Selumetinib_30min_R2 1 STTPTSSPFR 10 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.898)T(0.05)T(0.05)PT(0.002)S(0.001)SPFR 123.11 0.0042549 131380000.0 666180.0 672890.0 659550.0 778890.0 778390.0 559750.0 576010.0 547970.0 460100.0 628890.0 True False 629156.3825298343 724498.4993176315 617115.2710637446 672803.8383398049 680601.6893051086 636850.4815954126 602795.6063421625 549564.5019786824 552132.8562681183 610732.3116475476 1.0301671788620201 1.1862783178495688 1.010451320970685 1.1016345877047333 1.114402621778889 1.0427653317988155 0.9870046088048385 0.8998451391840472 0.9040505074615293 1.0 19.22018064943707 -7.300219278693138 2.1301560134486994 0.9278405462060035 1.0896058218668545 0.6204954157007754 0.0525336707179229 0.19477324786821193 1.726730602080815 0.02538877561671394 0.015881998160954317 5.009342441322441e-08 7.300219278693138 0.16176527566085097 S(ph)TTTGHLIYK ddPTM_A459_Selumetinib_30min_R1 2 STTTGHLIYK 10 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A6PW80;Q5JR01;A0A2R8Y660;A0A2R8Y488;A0A2R8YDN5 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 S(0.996)T(0.003)T(0.001)TGHLIYK;S(0.875)T(0.125)TTGHLIYK 180.66 0.00012575 54873000.0 5333.1 7585.2 6776.4 7734.4 8980.2 6384.2 9691.9 8244.4 2418.5 5824.4 True False 5457.350853593838 6697.121257736187 5856.2021001007815 6383.73223266932 8167.942495583083 6319.980744389812 8960.832180006544 8025.731730414618 4104.017859748834 6572.018474460349 0.8303918917455507 1.0190356712723803 0.8910811987000165 0.971350317634874 1.2428362043297179 0.9616498749889419 1.363482500061345 1.2211973781880823 0.6244683997310018 1.0 12.682120820484899 -6.018335669931128 22.583527281871685 1.0909736423687568 0.9252493799893827 0.11089205374217725 0.1938738751263192 435.5645777797504 536475.4403252046 0.05636778004170582 0.07440177319523178 9.586593890298179e-07 6.018335669931128 -0.1657242623793741 S(ph)TTTGHLIYK ddPTM_A459_Selumetinib_30min_R2 2 STTTGHLIYK 10 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A6PW80;Q5JR01;A0A2R8Y660;A0A2R8Y488;A0A2R8YDN5 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 S(0.941)T(0.057)T(0.001)TGHLIYK;S(0.875)T(0.117)T(0.008)TGHLIYK 99.343 0.018595 9196500.0 57452.0 61115.0 71520.0 74318.0 71736.0 54575.0 52817.0 55843.0 57518.0 68113.0 True False 54259.047838578284 65802.32398430219 66918.48106508823 64195.76019429915 62723.88235202312 62092.210867475864 55273.09515489999 56005.49388469369 69023.20718719745 66146.40071117281 0.8202872303740235 0.994798254732362 1.011672295780487 0.9705102545882867 0.9482584339835199 0.9387088367604535 0.8356175779880913 0.8466899677465562 1.0434915043765747 1.0 16.01337503541219 -7.00746987365243 23.71297644459701 0.9141724028190069 0.9550263913491095 0.0 0.0761874677273968 591.6967589335648 1878336.7097921476 0.027649712660959988 0.02336693552502752 9.829470561771721e-08 7.00746987365243 0.04085398853010258 S(ph)TVLGLPQHVQK ddPTM_A459_Selumetinib_30min_R1 3 STVLGLPQHVQK 12 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 S(0.5)T(0.5)VLGLPQHVQK;S(0.5)T(0.5)VLGLPQHVQK;S(0.737)T(0.263)VLGLPQHVQK 142.89 0.00087077 50966000.0 12446.8 11921.0 11930.099999999999 12097.7 10756.5 12811.5 12571.4 12403.6 8716.4 10397.3 True False 12736.786222743205 10525.283778077453 10310.057947348496 9985.063796954342 9783.576474214318 12682.62794191129 11623.129176707791 12074.61623542899 14791.094179332118 11731.894733278381 1.08565466297736 0.89715122896745 0.8788058691068255 0.8511041075599644 0.8339297868452983 1.0810383344078331 0.9907290715572082 1.0292128006551622 1.2607591966688974 1.0 13.518148410951417 -7.263102988263079 1.3219408118749238 1.1045092364416955 0.9097186378422766 0.3636960128355492 0.09995446237995233 0.4762567928602042 1.6226049325421523 0.06329010049354065 0.03664056057796487 5.4562845583137785e-08 7.263102988263079 -0.19479059859941894 S(ph)TVLGLPQHVQK ddPTM_A459_Selumetinib_30min_R2 1 STVLGLPQHVQK 12 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 S(0.5)T(0.5)VLGLPQHVQK 71.529 0.039671 22520000.0 161400.0 108220.0 121690.0 128750.0 107560.0 121300.0 147630.0 138960.0 122640.0 111660.0 True False 152430.0341353918 116520.12601785485 113860.59788605389 111214.02789386161 94047.35120139965 138007.97394823332 154495.0875232955 139364.35059393346 147171.4268479071 108436.08567247864 1.4057131737103907 1.0745512003245241 1.050024972590393 1.0256182451086762 0.8673067698649797 1.2727126130785824 1.4247571421005907 1.2852211487499727 1.3572181800477845 1.0 16.7264854152368 -6.964854398599315 24.801603349066156 1.298877244711541 1.0779926617061317 0.23188068804674355 0.16250843162225545 205.00382803003617 144666.76790888084 0.056761083526579555 0.05005838516036646 1.0842903718637639e-07 6.964854398599315 -0.22088458300540936 S(ph)VASS(ph)QPAKPTK ddPTM_A459_Selumetinib_30min_R2 2 SVASSQPAKPTK 12 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 2 S(1)VAS(0.003)S(0.998)QPAKPTK;S(1)VAS(0.058)S(0.942)QPAKPTK 162.72 0.016975 4951400.0 49030.0 45166.0 50070.0 54404.0 50955.0 36182.0 43829.0 40578.0 36821.0 52248.0 True False 46305.10888264104 48630.08696842012 46848.550712094046 46994.08134786529 44553.5773565203 41165.74207250598 45867.13534551587 40696.075261950486 44186.22886469976 50739.464483393065 0.9126053921557769 0.9584272806887163 0.9233158289919968 0.9261840231531487 0.8780852894319097 0.8113160533253057 0.9039735797867575 0.8020596132872123 0.8708453925279767 1.0 15.630820672478496 -6.284447567871856 3.879570909608346 0.8649395210650955 0.9325299114878401 0.17141992931410843 0.052754224408351466 0.29989946250455013 10.193171372125953 0.01557649290936531 0.018765351125495284 5.194603838809492e-07 6.284447567871856 0.06759039042274462 S(ph)VASSQPAKPTK ddPTM_A459_Selumetinib_30min_R2 1 SVASSQPAKPTK 12 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 S(0.994)VAS(0.006)SQPAKPTK 157.09 0.0020954 9994700.0 22902.0 22588.0 23149.0 23777.0 23471.0 16136.0 26623.0 19719.0 21197.0 21774.0 True False 21629.19852396992 24320.426968132542 21659.618542725504 20538.531582387193 20522.363146597745 18358.587531976023 27861.022252473686 19776.379025343806 25436.992293665036 21145.328044353868 1.0228830916503684 1.1501560494648593 1.0243217081944944 0.9713035210097534 0.9705388870558352 0.8682101073801053 1.3175970689143794 0.9352599772328624 1.2029604005342973 1.0 14.368051321769624 -7.231723083651897 24.99674253640222 1.1085595545049194 1.00629822339669 0.18041886414527153 0.11717202542756538 1351.1970873354653 1136600.9086866332 0.04378866341694331 0.033913800920506776 5.865120191322513e-08 7.231723083651897 -0.10226133110822944 S(ph)VAVSDEEEVEEEAER ddPTM_A459_Selumetinib_30min_R1 1 SVAVSDEEEVEEEAER 16 0 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(0.919)VAVS(0.081)DEEEVEEEAER 260.08 4.5221e-39 6376100.0 835.05 882.84 752.54 899.01 820.59 678.2 801.04 602.28 405.82 638.54 True False 854.5050402755505 779.4766823788187 650.3492014063282 742.0147800077635 746.3677793869317 671.3779237563309 740.6169078789962 586.3055779188442 688.6469000799143 720.5028289063097 1.1859842959571028 1.0818509672779892 0.9026324051961442 1.0298568586248413 1.0358984717934887 0.9318185811642847 1.0279167244953344 0.8137450047334709 0.9557865319213927 1.0 9.492860284631503 -1.522879514167567 0.7369406313738147 0.9530941729190207 40.1157705215332 0.5140974184610184 0.06790773018829709 282.1805326823381 1.2876405303721 0.026088339025360015 18313.194322999963 0.02999994688719883 1.522879514167567 39.16267634861418 S(ph)VAVSDEEEVEEEAER ddPTM_A459_Selumetinib_30min_R2 1 SVAVSDEEEVEEEAER 16 0 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(0.927)VAVS(0.073)DEEEVEEEAER 268.5 2.2655999999999994e-50 15165000.0 26490.0 23217.0 30499.0 36114.0 31818.0 23650.0 23647.0 25769.0 20432.0 18595.0 True False 25017.79184787194 24997.669245578752 28536.72754480041 31195.210899875136 27820.738383470944 26907.5728266753 24746.632355641563 25843.983523712413 24518.970917779123 18058.114034387803 1.3854044669465995 1.3842901422582699 1.580271754318216 1.7274899715701513 1.5406225882997702 1.4900544306806127 1.3703885305252206 1.4311562920966217 1.3577813757897421 1.0 14.140359607068483 -8.931433802860363 0.6397878017590625 0.9912370162709269 1.5222340984214782 0.7028868432454887 0.098200586463622 0.9080414999081572 0.6862573973491611 0.12922255351622408 0.045112260578441386 1.171025081685093e-09 8.931433802860363 0.5309970821505513 S(ph)VDALDDLTPPSTAESGSR ddPTM_A459_Selumetinib_30min_R2 1 SVDALDDLTPPSTAESGSR 19 0 S4R3V8;Q86X29-6;Q86X29-5;Q86X29-2;Q86X29-3;Q86X29-4;Q86X29 S4R3V8 LSR Lipolysis-stimulated lipoprotein receptor 1 S(1)VDALDDLTPPSTAESGSR 115.2 0.0004765 1900800.0 3906.0 3712.7 3914.2 3726.7 4277.8 3130.6 5085.8 3586.7 2384.1 3068.7 True False 3688.920156956878 3997.4521517879257 3662.364633458731 3219.1170310839216 3740.384519982778 3561.8117332426937 5322.299777321518 3597.13670318985 2860.986617319754 2980.0986575598727 1.237851689103942 1.3413824880083232 1.2289407346190018 1.0802048525869137 1.255121037853637 1.1951992677179124 1.7859475101000373 1.207052892045934 0.9600308399394909 1.0 11.541144377234206 -8.165448985111283 4.827992621419992 0.9826225490968827 1.299792910319063 0.3394480022413173 0.17659745312956338 0.25889135548756376 9.553411818394437 0.1348619602905876 0.0475840710669186 6.832049667041093e-09 8.165448985111283 0.31717036122218034 S(ph)VDAYDSYWESR ddPTM_A459_Selumetinib_30min_R2 3 SVDAYDSYWESR 12 0 Q9UM82 Q9UM82 SPATA2 Spermatogenesis-associated protein 2 1 S(1)VDAYDSYWESR;S(1)VDAYDSYWESR;S(1)VDAYDSYWESR 137.95 0.0016326 2247000.0 21340.2 19265.1 19389.7 28435.6 27063.6 17233.100000000002 21290.5 22097.5 14310.400000000001 23395.7 True False 20154.19711558916 20742.671222940055 18142.18781190914 24562.622225853942 23663.62861634623 19606.803098493805 22280.550436325393 22161.80006656194 17172.87986598408 22720.20535167123 0.8870605174396752 0.9129614324288793 0.7985045703195925 1.0810915590623036 1.041523535992407 0.8629676886723908 0.9806491663019455 0.9754225247322329 0.755841754076439 1.0 14.47168825393865 -5.7366845119311884 24.999999759074257 0.9563772484964617 0.8708541668777969 0.17340337550560259 0.09048113953651608 448.6329131049873 453071.82111160306 0.024869741092745336 0.04305223671782606 1.8336459690078233e-06 5.7366845119311884 -0.08552308161866473 S(ph)VDEIAK ddPTM_A459_Selumetinib_30min_R1 3 SVDEIAK 7 0 A6ND36;A6ND36-2 A6ND36 FAM83G Protein FAM83G 1 S(1)VDEIAK;S(1)VDEIAK;S(1)VDEIAK 113.66 0.014043 14916300.0 12874.4 10408.3 10937.0 11960.9 9249.6 8413.5 8148.6 7531.099999999999 4085.8 6313.5 True False 13174.348470778448 9189.691397312605 9451.815472640672 9872.153348900294 8412.97531314952 8328.867828846789 7533.944541524501 7331.350763539564 6933.304184974896 7123.899223697787 1.8493170744125247 1.2899805441860996 1.3267755727367712 1.3857794781908743 1.1809509159202585 1.1691445326936476 1.057559112636334 1.0291205045618395 0.973245685720978 1.0 12.79845139255308 -1.5228787452805381 0.30211075535542425 0.9804868818173311 7.4078426131124475 0.8424518942534791 0.09848650980594845 21.317758943978053 0.30397106041753424 0.10152188845734214 74.2253772378883 0.029999999999986145 1.5228787452805381 6.427355731295116 S(ph)VDEIAK ddPTM_A459_Selumetinib_30min_R2 2 SVDEIAK 7 0 A6ND36;A6ND36-2 A6ND36 FAM83G Protein FAM83G 1 S(1)VDEIAK;S(1)VDEIAK 112.11 0.014704 18877900.0 148485.0 125978.0 128049.0 142254.0 120245.0 88365.0 97834.0 99372.0 103955.0 112092.0 True False 140232.79813255055 135640.10751688495 119810.4667492098 122878.75979816227 105138.74809606084 100536.47665239603 102383.47485439322 99661.15606807968 124748.90474538592 108855.61271000771 1.2882459125569568 1.2460552482326415 1.100636556687122 1.1288233719791034 0.9658550944557298 0.9235764160386113 0.9405438296245108 0.9155353002658472 1.1460034226964306 1.0 16.732056270756082 -5.546448256091298 1.0654355048609425 0.9733331077871425 1.3060337888374793 0.7159880453330487 0.06874690665111419 0.3649933530802134 0.7092302106351632 0.02512973102331306 0.10351537143000437 2.8415267178140923e-06 5.546448256091298 0.3327006810503368 S(ph)VDEVNYWDK ddPTM_A459_Selumetinib_30min_R1 2 SVDEVNYWDK 10 0 F5H5P2;P12694;P12694-2;F5GXU9 F5H5P2 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1 S(1)VDEVNYWDK;S(1)VDEVNYWDK 186.51 7.4943e-05 25119000.0 3326.4 6152.9 2598.6000000000004 1523.02 2823.9 3378.5 4250.200000000001 4546.7 1707.7199999999998 4014.0 True False 3403.8986479523282 5432.5156075943905 2245.7243930880554 1257.0531476261924 2568.4787436000383 3344.5153574325636 3929.603992144351 4426.106746236979 2897.8761130660655 4529.235999671011 0.7515392547881312 1.1994331070381385 0.4958285223492831 0.2775419845019117 0.5670887416302891 0.7384281493999205 0.8676085751393359 0.9772303202037776 0.6398156583751781 1.0 12.145051998853486 -7.111700681873124 3.7155127187585295 0.8685607040326231 0.6578318969656053 0.1508231086926265 0.2373643405348099 0.5556230569452911 13.77414773392447 0.1052482662028841 0.08063047590962108 7.732133043268876e-08 7.111700681873124 -0.2107288070670178 S(ph)VDEVNYWDK ddPTM_A459_Selumetinib_30min_R2 2 SVDEVNYWDK 10 0 F5H5P2;P12694;P12694-2;F5GXU9 F5H5P2 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1 S(1)VDEVNYWDK;S(1)VDEVNYWDK 234.87 1.3211e-06 23027000.0 84462.0 44607.0 66062.0 79775.0 69983.0 57313.0 126140.0 106798.0 91794.0 48530.0 True False 79767.94016817509 48028.21346588842 61811.64284286723 68909.50738044905 61191.109884041936 65207.345514386536 132005.75994166802 107108.76449863931 110155.36493865564 47128.81280391716 1.692551444061521 1.019083881143225 1.3115467834939754 1.4621524133686978 1.298380040648 1.3835983050471996 2.8009566141818074 2.2726811503670397 2.3373252663283717 1.0 15.524321719220692 -7.166145148356321 8.872941300452206 2.2078107525087978 1.342480342826763 0.3802411213349334 0.45572364169577595 0.3092730839845758 26.51134714447404 0.1632260256797958 0.12638686598991986 6.821106834359757e-08 7.166145148356321 -0.8653304096820347 S(ph)VDEVNYWDKQDHPISR ddPTM_A459_Selumetinib_30min_R1 1 SVDEVNYWDKQDHPISR 17 1 F5H5P2;P12694;P12694-2 F5H5P2 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1 S(0.997)VDEVNY(0.003)WDKQDHPISR 73.722 0.013455000000000002 7848900.0 1400.9 2070.2 1463.2 1290.2 1854.9 1676.3 1391.9 1865.2 748.54 1035.7 True False 1433.538244323117 1827.8200215901295 1264.5054767822835 1064.890790053521 1687.1246225091934 1659.437943958622 1286.9078623748806 1815.7288369765363 1270.2177088014862 1168.6421835723143 1.2266699460916826 1.5640544619079515 1.082029636237273 0.9112205643632979 1.4436622656833917 1.4199709434465557 1.1011992211688362 1.5537081088637437 1.0869175583912907 1.0 10.190617555843744 -8.507933270373199 23.706099833076575 0.9999998671545363 1.2834471476356404 0.19412389777572514 0.20289127220715616 525.0915909145739 832885.1858676587 0.19731725247714416 0.05094709551924138 3.1050366423571068e-09 8.507933270373199 0.2834472804811041 S(ph)VDFDSLTVR ddPTM_A459_Selumetinib_30min_R1 4 SVDFDSLTVR 10 0 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 S(0.995)VDFDS(0.005)LTVR;S(1)VDFDSLTVR;S(1)VDFDSLTVR;S(1)VDFDSLTVR 215.04 0.00017119 211272000.0 8058.6 9546.3 9982.4 10853.9 9356.6 9149.6 8819.0 8564.400000000001 4885.67 8071.6 True False 8246.349700694027 8428.614758045527 8626.84490939822 8958.470117936691 8510.297182041902 9057.563331172109 8153.775729782368 8337.244290908127 8290.625154781508 9107.668484041984 0.9054292781015122 0.9254415411379694 0.9472067329321177 0.9836183797898759 0.9344100739891041 0.9944985752437446 0.8952648797075804 0.9154092845513914 0.9102906160130818 1.0 13.152866063495752 -5.763990769802237 0.0036004345735456446 1.8715127581613764 2.4810236262304535e-08 0.0968711485237822 0.0348372731040377 136447.82590348154 110.08916552454826 28097.622091596586 29130.266391686157 1.721905170791444e-06 5.763990769802237 -1.87151273335114 S(ph)VDFDSLTVR ddPTM_A459_Selumetinib_30min_R2 6 SVDFDSLTVR 10 0 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 S(0.999)VDFDS(0.001)LTVR;S(1)VDFDSLTVR;S(1)VDFDSLTVR;S(1)VDFDSLTVR;S(1)VDFDSLTVR;S(1)VDFDSLTVR 172.17 0.00015231 28836600.0 54140.4 56590.7 62971.5 58080.2 68858.7 55009.3 52883.6 49922.4 46959.1 64584.2 True False 51131.49330919311 60931.024722219656 58919.98224818515 50169.576566066586 60208.05450141146 62586.33175029304 55342.79218686541 50067.66591890177 56352.23214688146 62719.48633609616 0.815240944978308 0.9714847534896469 0.9394206759355374 0.7999041366063152 0.9599577104119342 0.9978769822015189 0.882385928518274 0.7982792724194705 0.8984804474466777 1.0 15.936626123578442 -1.5369501049123206 24.952470219458576 0.903844500433493 0.004554383519006278 0.0 0.07573968455561507 0.0 0.0 0.017359562200716407 0.0 0.02904356310070805 1.5369501049123206 -0.8992901169144867 S(ph)VDIHDSIQPR ddPTM_A459_Selumetinib_30min_R2 1 SVDIHDSIQPR 11 0 E5RHL7;E5RIF2;Q9Y6D6 E5RHL7 ARFGEF1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 1 S(0.999)VDIHDS(0.001)IQPR 71.555 0.04173 8019400.0 25489.0 16697.0 35199.0 68203.0 81539.0 44723.0 31676.0 38251.0 49222.0 54907.0 True False 24072.423420551426 17977.606210683047 32934.334661773515 58913.633743262544 71295.34185209114 50883.18729502748 33148.99676480325 38362.304077206056 59067.77537759025 53321.692244481346 0.45145647872874584 0.33715370713020987 0.6176535904143614 1.1048717935121413 1.337079504626375 0.9542680502660482 0.6216793835577129 0.7194502361499311 1.1077625801289832 1.0 15.702434946810172 -5.570948470024718 4.328571341616019 0.9637148627320178 0.4072712139687264 0.609375151638585 0.19170741031073013 0.15346259688238023 6.140137296387165 0.060199457683947834 0.11201352930464288 2.685663086461668e-06 5.570948470024718 -0.5564436487632913 S(ph)VEAAAELSAK ddPTM_A459_Selumetinib_30min_R1 1 SVEAAAELSAK 11 0 P20962;F5H7R9;F5GXR3 P20962 PTMS Parathymosin 1 S(1)VEAAAELSAK 199.4 1.9415e-05 7059600.0 2005.8 2696.6 1800.1 1316.4 2033.0 1629.6 2314.9 2333.3 1228.5 2237.9 True False 2052.5312373926095 2380.8808183846695 1555.6563072415167 1086.5154518884333 1849.1155089553015 1613.2077035584143 2140.2852292633193 2271.4133043734455 2084.674773910044 2525.1562639919684 0.8128333547753612 0.9428647455745108 0.6160633816705708 0.4302765208560927 0.7322776555744999 0.6388546034011087 0.8475852602800057 0.8995139575174703 0.8255626804712767 1.0 11.302156953441632 -7.39815709687075 4.43192636481326 0.8932666466641253 0.6932042624450458 0.3559961443286517 0.13137908495604989 0.30819526830752997 9.696824554207279 0.06373412646588249 0.041577015925373745 3.9980010434440023e-08 7.39815709687075 -0.2000623842190794 S(ph)VEDDEEGHLICQSGDVLSAR ddPTM_A459_Selumetinib_30min_R1 3 SVEDDEEGHLICQSGDVLSAR 21 0 F8WBF5;P49759;P49759-3 F8WBF5 CLK1 Dual specificity protein kinase CLK1 1 S(1)VEDDEEGHLICQSGDVLSAR;S(1)VEDDEEGHLICQSGDVLSAR;S(1)VEDDEEGHLICQSGDVLSAR 217.29 1.6154e-20 66747900.0 4527.61 5111.24 5421.4 5596.7 5558.0 5041.139999999999 5323.5 5434.6 2407.52 4129.33 True False 4633.094503804542 4512.813644648987 4685.203657618559 4619.341408070488 5055.2798813446025 4990.430708588897 4921.944109025562 5290.456753931316 4085.385601696305 4659.369728580342 0.9943607770350078 0.9685459423766294 1.0055445114990025 0.9914090697150899 1.0849707526611951 1.0710527387379978 1.0563540555355808 1.1354447193747939 0.8768107790709875 1.0 12.18591909985314 -6.182328694868607 9.736339649271665 1.0468150543514472 0.9894058893524937 0.10454863394559066 0.06465756758983762 0.9506342347357878 112.35577310427638 0.01839033935054265 0.023760091567516906 6.571602787111349e-07 6.182328694868607 -0.05740916499895343 S(ph)VEDDEEGHLICQSGDVLSAR ddPTM_A459_Selumetinib_30min_R2 2 SVEDDEEGHLICQSGDVLSAR 21 0 F8WBF5;P49759;P49759-3 F8WBF5 CLK1 Dual specificity protein kinase CLK1 1 S(1)VEDDEEGHLICQSGDVLSAR;S(1)VEDDEEGHLICQSGDVLSAR 112.61 6.1452e-05 44362000.0 41587.6 37297.0 48068.0 51986.0 57083.0 40508.1 48836.0 50123.0 38233.5 41877.1 True False 39276.327680353315 40157.559971243085 44975.35721248128 44905.41711914795 49911.723211505225 46087.72307908014 51106.97076669816 50268.84963169063 45881.2683332473 40667.99931322727 0.9657796878042801 0.9874486242105801 1.1059151660271873 1.1041953840237835 1.2272972374933484 1.1332675287050598 1.25668760769541 1.2360787469409806 1.1281909390198208 1.0 15.311606397841926 -5.396947120829496 1.28755932434674 1.1772718110143594 0.94631637124913 0.48796975095485895 0.07148881607622061 0.4476223453184394 1.2355981195081758 0.021976836163229162 0.10175154321528687 4.009155296452712e-06 5.396947120829496 -0.23095543976522936 S(ph)VEDLVR ddPTM_A459_Selumetinib_30min_R1 2 SVEDLVR 7 0 Q7L9B9 Q7L9B9 EEPD1 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 1 S(1)VEDLVR;S(1)VEDLVR 114.89 0.013438 6125200.0 4217.0 2771.0 4216.8 2368.33 5659.200000000001 3199.0 3557.3 4988.5 1813.8200000000002 4026.4 True False 4315.24789514639 2446.570031797048 3644.1817212243946 1954.7456245601122 5147.326359212911 3166.8209644596036 3288.969997001341 4856.188775068329 3077.9200638286675 4543.227660457238 0.9498198676471555 0.53850923058318 0.8021129455919975 0.4302548255667609 1.1329668561436068 0.6970421033536518 0.7239280623393488 1.068885193083103 0.6774743186694943 1.0 12.149501885100408 -6.258716662343494 24.999187979147237 0.8695372416077787 0.6787652167698579 0.20318311954189272 0.1959884105154268 416.8134273000622 3827054.4586336426 0.05588669750347422 0.06891145822853077 5.511671655868697e-07 6.258716662343494 -0.19077202483792077 S(ph)VEDLVR ddPTM_A459_Selumetinib_30min_R2 2 SVEDLVR 7 0 Q7L9B9 Q7L9B9 EEPD1 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 1 S(1)VEDLVR;S(1)VEDLVR 112.11 0.014704 8863200.0 69115.0 23955.0 45522.0 51280.0 32255.0 21777.0 71519.0 45619.0 36320.0 27161.0 True False 65273.86498926651 25792.271472534732 42593.16408060608 44295.57553706588 28202.838536641382 24776.58407807645 74844.77521220998 45751.743737368 43585.01486559016 26376.791357246955 2.4746704064644574 0.9778396137424188 1.6147970199909747 1.6793390423090937 1.0692293143112999 0.9393327544090819 2.837523874625735 1.7345454614894933 1.6524001829970607 1.0 14.686981456097485 S(ph)VEDVRPHHTDANNQSACFEAPDQK ddPTM_A459_Selumetinib_30min_R1 1 SVEDVRPHHTDANNQSACFEAPDQK 25 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.986)VEDVRPHHT(0.014)DANNQSACFEAPDQK 58.47 0.003976 16777000.0 3439.4 4427.9 3856.7 4344.3 5408.3 3464.2 4251.1 3668.5 944.46 2812.0 True False 3519.5313280926002 3909.479409525137 3332.9813233366813 3585.6495576108464 4919.12021991292 3429.3532932419353 3930.4361044197567 3571.199463032607 1602.6796393708426 3172.947591199521 1.1092308419635935 1.2321285798632347 1.0504369289240798 1.130068951518769 1.5503313806873391 1.0808099392355488 1.2387333832179277 1.1255147966949333 0.5051075043962373 1.0 11.631607976563403 -8.11316791969096 6.381006142479303 0.7577050800272747 1.1994289869542376 0.5096620932188332 0.17263688946763026 0.18068652242025357 8.846667664873355 0.11439697101488742 0.04244627805993246 7.706054573349525e-09 8.11316791969096 0.44172390692696295 S(ph)VEDVRPHHTDANNQSACFEAPDQK ddPTM_A459_Selumetinib_30min_R2 5 SVEDVRPHHTDANNQSACFEAPDQK 25 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.998)VEDVRPHHT(0.001)DANNQSACFEAPDQK;S(0.994)VEDVRPHHT(0.005)DANNQS(0.001)ACFEAPDQK;S(0.997)VEDVRPHHT(0.002)DANNQS(0.001)ACFEAPDQK;S(0.929)VEDVRPHHT(0.061)DANNQS(0.01)ACFEAPDQK;S(0.882)VEDVRPHHT(0.083)DANNQS(0.035)ACFEAPDQK 74.058 0.00019208 72432400.0 244358.4 206335.1 304731.3 362767.0 341244.1 245527.9 218118.3 255463.7 216626.5 310654.9 True False 230777.9383721791 222160.33869808385 285125.2199243529 313357.50879201986 298373.9653970396 279347.13954463653 228261.23314321227 256207.05707270777 259957.85305013065 301685.4858586358 0.7649620190224111 0.7363971722596693 0.9451075152417417 1.0386893751290818 0.9890232688782784 0.925954852450321 0.756619870172247 0.8492521817664163 0.8616849839834259 1.0 18.20268576428085 -5.258381904404341 24.83273299801283 0.9163762763010497 0.7506795782877674 0.42837837730333816 0.07846980979841411 256.9212686140045 2086678.3345584578 0.023019444494918665 0.0557244473934524 5.515921737793906e-06 5.258381904404341 -0.16569669801328224 S(ph)VEEELHQR ddPTM_A459_Selumetinib_30min_R2 1 SVEEELHQR 9 0 F5H5A3;Q8IVH8-3;Q8IVH8-2;Q8IVH8 F5H5A3 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase;Mitogen-activated protein kinase kinase kinase kinase 3 1 S(1)VEEELHQR 101.71 0.011099 5721400.0 27537.0 21334.0 27799.0 28542.0 25535.0 20745.0 22648.0 22592.0 18730.0 24036.0 True False 26006.603779345012 22970.249200378054 26010.442605262702 24654.53036230372 22327.065014203632 23602.43544563971 23701.176876160625 22657.73897969307 22476.523359925763 23342.018226972043 1.1141540344310932 0.984072969912927 1.1143184943282778 1.0562295908849497 0.9565181895198926 1.011156585353307 1.0153867864250732 0.9706846580006403 0.9629211639443334 1.0 14.510641686102996 -6.174696941351198 6.526576728431169 0.9874884188232732 1.0654743193385516 0.5169303347901395 0.038423729563806255 0.2106507024993549 13.257902763476118 0.011028080734747345 0.014292506784951536 6.688104629660885e-07 6.174696941351198 0.07798590051527843 S(ph)VEEPTQPGGTGLSDSR ddPTM_A459_Selumetinib_30min_R1 2 SVEEPTQPGGTGLSDSR 17 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 S(1)VEEPTQPGGTGLSDSR;S(1)VEEPTQPGGTGLSDSR 184.21 6.2419e-08 15006800.0 2634.3999999999996 3165.0 2258.5 2236.2 2869.0 2073.63 2778.2 2801.2 1507.81 2228.44 True False 2695.7763943499285 2794.440328631418 1951.8081050524788 1845.6896486728301 2609.499456563089 2052.7711649053986 2568.6381372583464 2726.903076420047 2558.643443914776 2514.481980843764 1.07210010446976 1.1113383790062836 0.7762267218146962 0.7340238119556884 1.0377880917195679 0.8163793499194482 1.0215376991472453 1.084479068529655 1.017562847301134 1.0 11.296045499546079 -7.490598901412727 21.735414671965682 1.0412143007133048 0.9225358814135292 0.15837193060282273 0.11985038237899641 248.41928150615192 167272.2747783985 0.05384016366536554 0.036233602090812174 3.231477218784196e-08 7.490598901412727 -0.11867841929977563 S(ph)VEEPTQPGGTGLSDSR ddPTM_A459_Selumetinib_30min_R2 2 SVEEPTQPGGTGLSDSR 17 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 S(1)VEEPTQPGGTGLSDSR;S(1)VEEPTQPGGTGLSDSR 237.34 2.0407e-22 7632800.0 16517.2 14384.1 18199.8 21598.5 24788.0 16214.2 17401.9 18670.7 16426.6 15742.3 True False 15599.240147590417 15487.314217828729 17028.844682443974 18656.7470405093 21673.90983246834 18447.558872147103 18211.122831210687 18725.028645899227 19712.37899755241 15287.778895592539 1.020373217988368 1.0130519497697417 1.1138861177115391 1.2203700202576866 1.4177278452605644 1.2066866611647247 1.1912209717044604 1.224836437901234 1.2894207282939891 1.0 13.900091197688415 -5.571643619892708 2.7452622697252576 1.23742765796814 1.0189107580774814 0.41269948542628354 0.09755310836071159 0.23758577917131818 3.6005448245461364 0.027076057823060908 0.057001701726994945 2.6813677406423463e-06 5.571643619892708 -0.2185168998906586 S(ph)VELCCASR ddPTM_A459_Selumetinib_30min_R2 2 SVELCCASR 9 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(1)VELCCASR;S(1)VELCCASR 102.95 0.01567 12976700.0 16284.8 14224.7 18770.4 22174.1 18557.6 14124.7 14456.800000000001 14506.4 16651.1 17480.9 True False 15379.75600921951 15315.688750380512 17562.732899666284 19153.94932754392 16226.228380951046 16070.249213739567 15129.069845605736 14548.611222336203 19981.78527060651 16976.18099616724 0.9059608879459898 0.9021869379125009 1.034551463820483 1.128283760161862 0.9558232434382319 0.946635124670725 0.8911939528107923 0.8570014201439584 1.17704831699885 1.0 14.051224322682017 -5.241573600797784 22.73820938812874 0.9910910451978916 0.9040738233148315 0.1382349435864595 0.09303593617739765 578.1661504760251 661753.5732201162 0.0246055319052368 0.06481667252890613 5.733586900107012e-06 5.241573600797784 -0.08701722188306005 S(ph)VELDLNQAHMEETPK ddPTM_A459_Selumetinib_30min_R1 4 SVELDLNQAHMEETPK 16 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 S(1)VELDLNQAHMEETPK;S(1)VELDLNQAHMEETPK;S(1)VELDLNQAHMEETPK;S(1)VELDLNQAHMEETPK 207.1 4.8937e-08 53592000.0 13231.2 15798.0 15662.1 16541.800000000003 14161.0 13854.4 15312.3 14635.599999999999 7826.5 12546.5 True False 13539.461216566508 13948.362815709046 13535.272845757114 13653.085158043208 12880.140050327616 13715.037314788715 14157.280882996542 14247.41634487121 13280.998875056537 14156.965488259184 0.9563815937670547 0.9852650151105378 0.9560857414664421 0.9644076034066863 0.9098093840102613 0.9687836935226709 1.0000222784139454 1.0063891415633555 0.9381246910625647 1.0 13.78922443987149 -7.00422690777434 24.949962120811843 0.9863431069690997 0.9550099746444651 0.2667380316264285 0.024799807461105654 251.00518046067765 1481601.070382419 0.009001876756485512 0.0077657055099802025 9.903143957236011e-08 7.00422690777434 -0.03133313232463453 S(ph)VELDLNQAHMEETPK ddPTM_A459_Selumetinib_30min_R2 2 SVELDLNQAHMEETPK 16 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 S(1)VELDLNQAHMEETPK;S(1)VELDLNQAHMEETPK 190.37 6.6681e-07 25107300.0 115830.0 96068.0 115104.0 115294.0 112507.0 95358.0 101708.0 109954.0 87136.0 109420.0 True False 109392.63230422826 103436.10669269305 107698.3339557593 99590.75830675656 98372.86483465848 108492.6989262624 106437.62353057867 110273.94793613543 104565.63478326169 106260.7602926979 1.0294734575858815 0.973417717017794 1.0135287349638904 0.9372298676616969 0.9257685015963371 1.021004354075922 1.0016644266180064 1.037767352994493 0.9840474931219488 1.0 16.697249414839078 S(ph)VENLPECGITHEQR ddPTM_A459_Selumetinib_30min_R1 5 SVENLPECGITHEQR 15 0 Q9UBF8-2;A0A0B4J1S8;Q9UBF8;F8W860;Q9UBF8-3 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR 246.1 9.2861e-22 190000000.0 18000.8 20594.0 21990.8 24253.1 20599.2 17225.61 18654.28 17894.16 10371.880000000001 15214.119999999999 True False 18420.183616540475 18182.84490610915 19004.570146817816 20017.75137207181 18736.00599708414 17052.336003002507 17247.172640953017 17419.548748376612 17600.32282785683 17167.000500078415 1.0729995386472049 1.059174251554667 1.1070408104625504 1.1660599282897657 1.0913966011126148 0.993320644624238 1.004670130980321 1.0147112623604249 1.0252415864831155 1.0 14.067350366374134 -6.718860045089905 6.665272438498492 1.0083308790784014 1.1018187188053397 0.7369013896734851 0.027410022225204483 0.11238775672907517 12.690520431460438 0.010199515504841017 0.010061866423647398 1.9104688234089513e-07 6.718860045089905 0.0934878397269383 S(ph)VENLPECGITHEQR ddPTM_A459_Selumetinib_30min_R2 4 SVENLPECGITHEQR 15 0 Q9UBF8-2;A0A0B4J1S8;Q9UBF8;F8W860;Q9UBF8-3 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR;S(1)VENLPECGITHEQR 213.01 4.161e-07 332068000.0 530140.0 489314.0 577482.0 636040.0 661950.0 474795.0 491485.0 484583.0 415321.0 523919.0 True False 500676.94111856626 526842.8104075083 540327.4368348607 549410.2547698012 578789.923091917 540193.7014901185 514340.0263590512 485993.0563029653 498396.8050383189 508792.0971649603 0.9840501531143812 1.035477581792501 1.0619807969613098 1.0798325245835563 1.13757648028928 1.0617179482545642 1.0109041182538103 0.9551898683390849 0.979568683978063 1.0 18.9567167365106 -7.431184097989112 3.3659501070355353 0.9761039101264568 1.0633301603638947 0.49458175674513427 0.037367169829894985 0.22236612885630228 4.768553298176641 0.019370308463024274 0.011992563044244856 3.705236230476773e-08 7.431184097989112 0.08722625023743791 S(ph)VEPQDAGPLER ddPTM_A459_Selumetinib_30min_R1 2 SVEPQDAGPLER 12 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 S(1)VEPQDAGPLER;S(1)VEPQDAGPLER 103.14 0.010971 17043800.0 1491.6799999999998 1760.5 1986.01 2127.29 1846.01 1939.32 1926.01 1926.62 980.1500000000001 1143.3400000000001 True False 1526.4332416959855 1554.3798415657552 1716.3207503720503 1755.798735678931 1679.0387214395357 1919.8122015616743 1780.729515060452 1875.51977905626 1663.242962676379 1290.0988260747029 1.183190939209178 1.2048533105755646 1.3303792823331095 1.360980027414785 1.3014806986130156 1.4881125094911978 1.38030473252856 1.4537799284437598 1.2892368623704717 1.0 10.333265870021345 -5.265759542405723 3.1944302119500043 1.351829564927592 1.1856622044732328 0.124694907754342 0.1265398394084827 0.3811546480066944 7.99904424750391 0.031699224691000304 0.09009406294614793 5.423010653335532e-06 5.265759542405723 -0.1661673604543592 S(ph)VEPQDAGPLER ddPTM_A459_Selumetinib_30min_R2 4 SVEPQDAGPLER 12 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 S(1)VEPQDAGPLER;S(1)VEPQDAGPLER;S(1)VEPQDAGPLER;S(1)VEPQDAGPLER 147.51 0.00062782 44427300.0 60076.0 53415.5 65105.0 69584.0 76020.0 48439.7 54661.3 56168.7 41795.5 57052.0 True False 56737.21642328253 57512.29709209679 60916.21518096431 60106.53916090472 66469.68797257726 55111.82898318406 57203.15875931112 56332.14161777111 50155.76786384286 55404.76052110208 1.0240494840091035 1.0380389076890246 1.0994761931650816 1.084862358316879 1.1997107711937653 0.9947128814354057 1.0324592728367463 1.0167382926655881 0.9052609810440382 1.0 15.757722321259296 -7.536946123974479 1.4049732352093007 0.9626759776675846 1.0818637106342437 0.41000986556521224 0.05629616535720478 0.44472595346988825 1.672021676017503 0.04160261343001932 0.019283855631669074 2.9043829328242906e-08 7.536946123974479 0.11918773296665908 S(ph)VEYEGDLK ddPTM_A459_Selumetinib_30min_R2 1 SVEYEGDLK 9 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 S(1)VEYEGDLK 87.568 0.032348 11896000.0 55043.0 31394.0 38557.0 51508.0 49532.0 46866.0 62284.0 67153.0 48898.0 51524.0 True False 51983.93041458719 33801.81885237971 36076.28459768747 44492.52154374397 43309.34733830172 53321.36609281035 65180.329413404674 67348.40411222233 58678.966324273875 50036.368244570964 1.0389229322259521 0.6755450093252374 0.7210012609498654 0.8892036553546527 0.8655573707230613 1.065652203856658 1.3026590797879671 1.3459890570601065 1.1727263265283177 1.0 15.610689458707645 -6.881931411033214 2.432134368672887 1.233307231494793 0.817744452117776 0.6490521044276731 0.1270347817412635 0.16437900838191186 1.9793581914477363 0.050050941089906154 0.042949711759849254 1.3124071536506665e-07 6.881931411033214 -0.415562779377017 S(ph)VFGTPTLETANK ddPTM_A459_Selumetinib_30min_R1 1 SVFGTPTLETANK 13 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 S(0.922)VFGT(0.078)PTLETANK 198.37 0.0001526 27128000.0 2704.4 3361.6 3058.7 3030.5 3000.9 2347.3 2916.5 2586.9 1635.5 2241.0 True False 2767.4072581536393 2968.0223092345595 2643.345340236447 2501.2800645304574 2729.4691248519266 2323.6882931778755 2696.5060569123802 2518.287008564553 2775.3240478061684 2528.6541791885247 1.0944190316454159 1.173755720992672 1.045356601939427 0.9891744332288047 1.079415741114843 0.9189426977806727 1.0663799261699443 0.9959001231922909 1.0975498629459892 1.0 11.304154031001262 -5.401876749133368 5.210860035102812 1.0207159419562244 1.1328569847952286 0.4221940937614884 0.05203142612458073 0.1886157047091827 7.182033400903857 0.012847885054902941 0.027450805628537946 3.963905121808048e-06 5.401876749133368 0.11214104283900417 S(ph)VGDGETVEFDVVEGEK ddPTM_A459_Selumetinib_30min_R1 2 SVGDGETVEFDVVEGEK 17 0 H0Y449;P67809;A0A0D9SEI8;Q9Y2T7;P16989-2;P16989;P16989-3 H0Y449;P16989-2 YBX1;YBX3;YBX2 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 1 S(0.976)VGDGET(0.024)VEFDVVEGEK;S(1)VGDGETVEFDVVEGEK 314.11 1.8686999999999998e-103 23010000.0 4661.8 5642.6 5569.5 5862.6 5471.9 5730.299999999999 5931.8 7532.6 3710.13 4338.46 True False 4770.410869716256 4981.961768826427 4813.192491073623 4838.806964631664 4976.967611142408 5672.658384696109 5484.359550280422 7332.810978666874 6295.819632826109 4895.343601179046 0.9744792722143751 1.0176939914139058 0.9832185201288758 0.9884509360009448 1.0166738060927332 1.158786562669441 1.120321676492639 1.4979154837876472 1.2860832958302983 1.0 12.257194409929218 -7.07640018962266 1.6196729921905915 1.2808427618279659 0.9928793881844484 0.44256936801652447 0.12089511006529423 0.30574043744844526 1.601021505040427 0.05925287696456151 0.04183410416135758 8.386868050587133e-08 7.07640018962266 -0.28796337364351743 S(ph)VGGDSDTEDMR ddPTM_A459_Selumetinib_30min_R2 1 SVGGDSDTEDMR 12 0 Q9UK61-3;Q9UK61;Q9UK61-2;A0A087X0F1;Q9UK61-4 Q9UK61-3 FAM208A Protein FAM208A 1 S(0.929)VGGDS(0.07)DT(0.001)EDMR 198.97 0.00011796 19251000.0 49228.0 36909.0 47390.0 41045.0 45412.0 35912.0 40614.0 35576.0 36722.0 37742.0 True False 46492.1048352978 39739.80161885975 44340.97899433072 35454.60019342568 39706.938571569 40858.55202332191 42502.63147511424 35679.52027007616 44067.42609840863 36652.29039450736 1.268463834998563 1.084237879573689 1.2097737553933483 0.9673229097502412 1.0833412631020571 1.1147612218374459 1.159617339534219 0.973459499693995 1.2023102955937641 1.0 15.161615734458373 -1.8047688729425795 1.1211012748754272 1.0838517922125428 199.90980853494005 0.29091039506670424 0.08353574592815653 2099.007402000493 3.2612583763378473 0.0239273374331057 1072520.6615427323 0.015675851008283673 1.8047688729425795 198.8259567427275 S(ph)VGGSGGGSFGDNLVTR ddPTM_A459_Selumetinib_30min_R1 1 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.796)VGGS(0.019)GGGS(0.177)FGDNLVT(0.008)R 72.428 0.027431 27974000.0 1110.8 1392.4 1272.2 1520.0 1356.8 995.89 1185.0 1417.4 577.05 750.2 True False 1136.6794787594522 1229.3771606908012 1099.4422276943828 1254.5605339337712 1234.077679562496 985.8722507957723 1095.6144959510268 1379.8059476359329 979.2117039355245 846.4954775668145 1.3428063219271402 1.4523139145699282 1.2988164223329863 1.4820640714347442 1.457866831267376 1.1646515272941391 1.2942945650463313 1.6300216412284656 1.1567831487419076 1.0 9.725358550264977 -8.515828948409542 23.003438846379026 0.9999999804895268 1.384541219161575 0.535785075504946 0.12055189985046169 112.79774648245063 368056.5557813149 0.11601387574452747 0.029954653937707843 3.0490956725513783e-09 8.515828948409542 0.38454123867204815 S(ph)VGGSGGGSFGDNLVTR ddPTM_A459_Selumetinib_30min_R2 2 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.912)VGGS(0.063)GGGS(0.026)FGDNLVTR;S(1)VGGSGGGSFGDNLVTR 134.33 0.00056093 17887400.0 22794.4 16808.8 17378.4 21714.7 25157.0 17238.1 18052.1 17950.8 19239.9 18993.9 True False 21527.578501212975 18097.980911189392 16260.292664171282 18757.12040005312 21996.5527535665 19612.491803108307 18891.558419557543 18003.033856085087 23088.417607722124 18445.496754921132 1.1670912845147183 0.9811598544431163 0.8815318383785542 1.016894293998824 1.1925161488371392 1.0632672062830635 1.024182686460716 0.9760124162165489 1.2517102637294 1.0 14.170981022266698 -6.021387885493152 24.38187925572036 1.0816335908329264 0.9974112386137588 0.1045893896095671 0.10254866326384778 1194.602569499843 1361830.4399857998 0.03031230500874966 0.03956579248381324 9.519455641815563e-07 6.021387885493152 -0.08422235221916763 S(ph)VHREESCSDSGTK ddPTM_A459_Selumetinib_30min_R2 1 SVHREESCSDSGTK 14 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 S(0.999)VHREESCSDSGTK 68.845 0.034214 8563100.0 13242.0 11130.0 9951.1 14256.0 11713.0 12840.0 15910.0 24871.0 13763.0 24124.0 True False 12506.062651926013 11983.63521140938 9310.857059938478 12314.308207028305 10241.508224451418 14608.593450085034 16649.84652506692 24943.3704923843 16515.984570350138 23427.477438320602 0.5338202836755143 0.5115205101769773 0.3974331886329597 0.5256352605375108 0.4371579591279111 0.6235666425694465 0.7106973667524515 1.0647057737246663 0.7049834799257878 1.0 14.515913999429161 -7.316478409002532 1.8980388476241399 0.9134551337510745 0.4830521661236486 0.7721361298856313 0.10228132575888578 0.15158380372668728 1.0644801451949524 0.0510774627604371 0.030722498836995644 4.82526968344199e-08 7.316478409002532 -0.43040296762742586 S(ph)VIEPLPVTPTR ddPTM_A459_Selumetinib_30min_R2 1 SVIEPLPVTPTR 12 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 S(0.602)VIEPLPVT(0.282)PT(0.117)R 143.04 0.00085892 7279100.0 16569.0 13201.0 18541.0 19517.0 20171.0 18251.0 18414.0 20064.0 16526.0 20153.0 True False 15648.161310962241 14213.4742520948 17348.092245914453 16858.750931297094 17636.93864897205 20764.909583917593 19270.28748664879 20122.382918225998 19831.66177502045 19571.13052621767 0.7995532649480733 0.7262469704064514 0.8864123726871469 0.8614091510305424 0.9011711727815336 1.0609969391446614 0.9846282237418086 1.02816660955124 1.0133120183554942 1.0 14.256439475190172 -6.086753587258841 0.9093599475173688 1.021742303098084 0.762574869604633 0.8378303429978984 0.04174228475605771 0.22887386268523063 0.3910836636480178 0.019095646258669816 0.038476277763722644 8.18929305614272e-07 6.086753587258841 -0.25916743349345084 S(ph)VLT(ph)RHQIIHT(ph)GLKPY(ph)ECY(ph)ECGK ddPTM_A459_Selumetinib_30min_R2 1 SVLTRHQIIHTGLKPYECYECGK 23 2 A0A087WXT3;Q06732 A0A087WXT3 ZNF33B Zinc finger protein 33B 5 S(1)VLT(1)RHQIIHT(1)GLKPY(1)ECY(1)ECGK 43.476000000000006 0.042115 0.0 8056.5 9627.1 8381.0 9341.9 10087.0 8684.3 6541.1 5033.5 3947.4 8821.2 True False 7608.751982724809 10365.467613994539 7841.775584542848 8069.517104323635 8819.780881075856 9880.483496773626 6845.274110943755 5048.146651659215 4736.9902995713255 8566.509035769917 0.8881975085713513 1.2099990288591274 0.9153992077518501 0.9419843101348442 1.0295653508621059 1.1533850551627434 0.7990739380955469 0.5892886624622012 0.5529662409496995 1.0 13.064491691702079 -7.4659545335361255 5.130883169694885 0.6796785189408843 1.0220110991608948 0.4812834104181565 0.14685279755025327 0.15757633328802634 8.78899214799144 0.062183565683286694 0.04015676581236293 3.4201524635313023e-08 7.4659545335361255 0.34233258022001056 S(ph)VNDEGSSDPK ddPTM_A459_Selumetinib_30min_R2 2 SVNDEGSSDPK 11 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 S(1)VNDEGSSDPK;S(1)VNDEGSSDPK 104.41 0.011382 0.0 44134.0 33379.0 32849.0 44046.0 44771.0 33985.0 53765.0 58060.0 44231.0 38066.0 True False 41681.208962400146 35939.06196959872 30735.531103286972 38046.85881641195 39146.46672218172 38666.12526488627 56265.17903332635 58228.94498764959 53078.43591739859 36966.93567265426 1.127526753407186 0.9721947820572021 0.831433023701316 1.0292132178149824 1.058958932079938 1.0459651188640167 1.5220406563194708 1.5751628834824842 1.4358354283788408 1.0 15.173947837651497 -7.2049552540909065 5.963012071380018 1.4308205474658537 1.001358251663273 0.5490258012753877 0.16307907814466935 0.14364042686954182 11.240799973623275 0.06164039954772471 0.047138317745276034 6.237991029811766e-08 7.2049552540909065 -0.42946229580258066 S(ph)VNDLLDETSTFKPGHAR ddPTM_A459_Selumetinib_30min_R1 1 SVNDLLDETSTFKPGHAR 18 1 C9J119;Q6ZWE6-3;Q6ZWE6-2;Q6ZWE6 C9J119 PLEKHM3 Pleckstrin homology domain-containing family M member 3 1 S(1)VNDLLDETSTFKPGHAR 68.413 0.011819 29306000.0 3416.0 5175.0 4369.0 4895.0 3756.9 3868.3 4542.7 3277.2 2136.4 3299.4 True False 3495.5861536210755 4569.108594207769 3775.713797199152 4040.1801405301394 3417.089058334567 3829.3884141353797 4200.0404816512455 3190.2780101541416 3625.3147635176397 3722.91012887756 0.938939171941542 1.2272948945950874 1.0141834388942157 1.0852209697976876 0.9178542967849733 1.028600820748236 1.1281605884258985 0.8569312445680755 0.9737851943825072 1.0 11.862215074585704 -6.233422738665311 24.39592099286126 0.9864844465831396 1.0741710007757062 0.15169391721650327 0.09441354653253917 1008.9900353039957 878592.2855382782 0.02748074477613933 0.035468322095371166 5.842211312536385e-07 6.233422738665311 0.08768655419256655 S(ph)VPEDDGHALLAER ddPTM_A459_Selumetinib_30min_R1 2 SVPEDDGHALLAER 14 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(1)VPEDDGHALLAER;S(1)VPEDDGHALLAER 202.92 4.1387e-05 16354000.0 912.3299999999999 1066.28 926.61 1112.51 1205.3999999999999 1236.58 1186.1 1117.46 411.52 965.96 True False 933.5855139148462 941.4394418998769 800.7814515043955 918.2310128991192 1096.3717828306549 1224.1411279248064 1096.6315220654114 1087.8213307783622 698.3193837683851 1089.950375247188 0.8565394674075137 0.8637452339849595 0.7346953308060357 0.8424521278694684 1.0058914678404607 1.1231163874292767 1.0061297715657085 0.9980466592634155 0.6406891539534674 1.0 10.09004673616469 -6.185775892513993 5.613268909621723 0.9722357591239266 0.8185722801741172 0.23516579973220397 0.12132123852405312 0.3315372074262899 18.53162176082303 0.037423324459872974 0.048505016373722926 6.519647383909926e-07 6.185775892513993 -0.15366347894980936 S(ph)VPEDDGHALLAER ddPTM_A459_Selumetinib_30min_R2 2 SVPEDDGHALLAER 14 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(1)VPEDDGHALLAER;S(1)VPEDDGHALLAER 166.48 0.00015358 20429400.0 18048.8 14796.6 20776.1 19004.5 22664.1 11320.3 14124.1 18670.6 15104.5 18467.3 True False 17045.719951071005 15931.451641432166 19439.38834530732 16416.054315408903 19816.83313837525 12879.56856954809 14780.898636373206 18724.928354915788 18125.822054991913 17934.10106519226 0.9504641403050034 0.8883328795527436 1.0839343591654353 0.915354176701408 1.1049805655906069 0.7181608112238 0.8241783952618063 1.0440962882303826 1.0106903038575912 1.0 14.130417812534237 -7.812206990960653 24.99987340907714 1.0205451862096835 0.9294985093059732 0.1339902397781687 0.10668107951389971 243.4772929189963 119893.92049862815 0.060549449834848085 0.029087070989740085 1.5409658315462152e-08 7.812206990960653 -0.09104667690371027 S(ph)VPGTTLESFR ddPTM_A459_Selumetinib_30min_R1 2 SVPGTTLESFR 11 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(1)VPGTTLESFR;S(1)VPGTTLESFR 124.21 0.0036397 18633500.0 1429.56 1372.3899999999999 1347.25 1664.46 1459.46 1272.3899999999999 1338.85 1273.16 930.79 1300.95 True False 1462.8659665604634 1211.7099407931976 1164.3008499145242 1373.7933067838196 1327.4521006885905 1259.590911837685 1237.8594665856806 1239.3916609934843 1579.4826477881402 1467.93960482611 0.9965437009472555 0.8254494509239261 0.793153101181193 0.935865005799443 0.9042961279362978 0.8580672581464238 0.8432632122711312 0.8443069843737206 1.075986125447745 1.0 10.51957689752287 -8.259298941413412 24.987519900570636 1.0379930733108276 0.8720976203178754 0.5571046907605439 0.05803936999254305 128.52171760082032 1500411.929682588 0.04372018440130315 0.014661823956613636 5.504286849729886e-09 8.259298941413412 -0.16589545299295216 S(ph)VPGTTLESFR ddPTM_A459_Selumetinib_30min_R2 2 SVPGTTLESFR 11 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(1)VPGTTLESFR;S(1)VPGTTLESFR 114.71 0.0063881 7458400.0 8874.8 7329.200000000001 7911.299999999999 5578.2 11346.8 6028.4 8671.1 7210.700000000001 3993.1 8548.5 True False 8381.574144639257 7891.326072907608 7402.295571172156 4818.439537068272 9921.31354232096 6858.757379633379 9074.323331458689 7231.6819432043585 4791.831576536014 8301.682593329608 1.009623537206041 0.9505694760298689 0.8916620803016357 0.5804172205933148 1.19509670850253 0.8261888240757822 1.0930703781363427 0.8711103877923503 0.5772120919663015 1.0 13.01918805763188 -8.009905833537383 24.7156448227963 0.767124427500661 0.9302857065056029 0.09193504277451836 0.18120796591361013 836.6859885848118 2087569.4339936338 0.1040146792850921 0.04521128982601426 9.774491346532928e-09 8.009905833537383 0.16316127900494193 S(ph)VPHLQK ddPTM_A459_Selumetinib_30min_R2 2 SVPHLQK 7 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 S(1)VPHLQK;S(1)VPHLQK 109.44 0.010479 3961800.0 69996.0 36428.0 51326.0 73771.0 52948.0 40186.0 83761.0 77784.0 60896.0 41167.0 True False 66105.90253618892 39221.9104655185 48023.741039523484 63723.26253792688 46296.19887887422 45721.256727812826 87656.05246927276 78010.33856216553 73076.90157640348 39978.401745288655 1.6535404030747507 0.9810775006817448 1.2012421443331698 1.5939422227011988 1.1580302577836319 1.1436489387222928 2.1925852120789893 1.9513120874412855 1.8279095308009754 1.0 15.286933176788668 -7.2453062310126555 24.961323354243053 1.8222277361256438 1.2785789186501741 0.2818026412284971 0.34600499972709603 842.3785725674193 1303336.0175964436 0.12661629717055264 0.09775982057314977 5.6845196096188585e-08 7.2453062310126555 -0.5436488174754697 S(ph)VPNT(ph)PLRPNQQSVVNSSFSELFVK ddPTM_A459_Selumetinib_30min_R1 2 SVPNTPLRPNQQSVVNSSFSELFVK 25 1 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 2 S(0.865)VPNT(0.818)PLRPNQQS(0.31)VVNS(0.005)S(0.002)FS(0.001)ELFVK;S(0.991)VPNT(0.95)PLRPNQQS(0.042)VVNS(0.013)S(0.004)FSELFVK 70.028 0.004126 10080300.0 888.8399999999999 1003.35 836.5799999999999 1105.94 1022.74 896.8 1170.85 940.8499999999999 624.8100000000001 850.9200000000001 True False 909.5482426184296 885.8773155552396 722.977031005005 912.8083400649448 930.2333475794126 887.7790062292503 1082.5318418432564 915.8956016884912 1060.2569356831386 960.1438706626948 0.9473041180699889 0.9226505970858345 0.752988227176833 0.9506995440536647 0.9688478737435069 0.9246312280434619 1.127468366898066 0.9539149596990467 1.1042688164549188 1.0 9.907106789296042 -6.712649102576087 1.2892125414020041 1.0401019499625008 0.8850657120218095 0.43281237393617567 0.07380694348628299 0.4134078389305418 1.4439824390669778 0.03469723057646583 0.03272782518482325 1.937987169316163e-07 6.712649102576087 -0.15503623794069132 S(ph)VPNTPLRPNQQSVVNSSFSELFVK ddPTM_A459_Selumetinib_30min_R1 2 SVPNTPLRPNQQSVVNSSFSELFVK 25 1 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 S(0.985)VPNT(0.015)PLRPNQQSVVNSSFSELFVK;S(0.957)VPNT(0.043)PLRPNQQSVVNSSFSELFVK 113.92 5.3569e-08 115725000.0 1911.0 2437.3 2342.3 2392.21 2440.12 2030.01 2242.0099999999998 2030.0700000000002 1098.92 2174.7400000000002 True False 1955.522581841298 2151.939782929972 2024.2285253329292 1974.4554308432305 2219.411576838177 2009.5899425016055 2072.8933806473933 1976.2259490033005 1864.786978058792 2453.889062761468 0.7969074932999064 0.8769507210355715 0.8249062910182977 0.8046229394825576 0.9044465825771997 0.8189408286616375 0.8447380169316524 0.8053444546426918 0.7599312480574271 1.0 11.260854312708698 -11.932492515808237 2.4809239734368456 2.7738195709327047 0.8291269282585734 0.6387151299066376 0.039137742169036156 7515121.830890623 2052812.155870892 72976212.17409047 0.010036174188168379 1.168173860814443e-12 11.932492515808237 -1.9446926426741313 S(ph)VPNTPLRPNQQSVVNSSFSELFVK ddPTM_A459_Selumetinib_30min_R2 1 SVPNTPLRPNQQSVVNSSFSELFVK 25 1 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 S(0.828)VPNT(0.162)PLRPNQQS(0.002)VVNS(0.004)S(0.004)FS(0.001)ELFVK 50.705 0.018581 15560000.0 15583.0 14131.0 13065.0 17272.0 19705.0 12810.0 8419.1 11762.0 21359.0 14060.0 True False 14716.95924369152 15214.802261673487 12224.412124096441 14919.523804138096 17229.481735064917 14574.461222397907 8810.604832130164 11796.225472696078 25631.396820323233 13654.051267732862 1.0778456119079114 1.1143068063343937 0.895295607464509 1.0926811033290749 1.2618585793493746 1.0674092938877526 0.6452740406029754 0.8639359294462895 1.8772008627867929 1.0 13.73704145352903 -8.232196471943713 24.995011186195583 1.4386009536330164 1.0044215313844314 0.32209734940046675 0.2531539835986946 699.7472305872319 598102.116612808 0.16794395464182862 0.06345604118775473 5.858730594656156e-09 8.232196471943713 -0.4341794222485851 S(ph)VQEGENPDDGVR ddPTM_A459_Selumetinib_30min_R1 2 SVQEGENPDDGVR 13 0 H7C5M1;Q5TCT4;A2A2V2;P42696-2;P42696 H7C5M1 RBM34 RNA-binding protein 34 1 S(1)VQEGENPDDGVR;S(1)VQEGENPDDGVR 232.01 3.037e-13 65267000.0 955.26 1454.19 1269.1799999999998 1121.1299999999999 1250.26 1165.43 1521.43 1076.93 726.05 886.29 True False 977.515699387608 1283.9327587654097 1096.832327106711 925.3456917165586 1137.174203751331 1153.706832325775 1406.6673101896804 1048.3663180383562 1232.0538214060957 1000.0539546956704 0.9774629606710359 1.283863488301616 1.0967731510451268 0.9252957676650091 1.1371128511735031 1.1536445877831292 1.4065914179777907 1.0483097568044595 1.2319873499035618 1.0 9.965862122734118 -6.651115805994684 3.814449087226534 1.1862372792933547 1.0828717531874317 0.09083463819930271 0.13514343523017605 0.5401487959430541 14.811554370941414 0.0462635685400223 0.04581309465224506 2.232976713146636e-07 6.651115805994684 -0.10336552610592298 S(ph)VQEGENPDDGVR ddPTM_A459_Selumetinib_30min_R2 2 SVQEGENPDDGVR 13 0 H7C5M1;Q5TCT4;A2A2V2;P42696-2;P42696 H7C5M1 RBM34 RNA-binding protein 34 1 S(1)VQEGENPDDGVR;S(1)VQEGENPDDGVR 224.36 3.5931000000000008e-09 159534000.0 73880.0 71599.0 74515.0 77417.0 73919.0 67593.0 67414.0 68216.0 71483.0 111972.0 True False 69774.0453650728 77090.41307292914 69720.78602579776 66872.67104822613 64632.6343757555 76903.32220183781 70548.88457830678 68414.4972662332 85781.59740189908 108739.07742180518 0.6416648643653213 0.7089485666122672 0.6411750741212084 0.6149828804305849 0.5943827730397396 0.7072280179785356 0.6487905383328164 0.6291620168971032 0.788875530635112 1.0 16.730510967436864 -8.582940144027194 2.6473869128374368 0.999593659104769 0.6491783596051969 0.9072750217286756 0.034833402305270864 0.0916115049665324 1.547984351547834 0.03501843589444275 0.009432388102758458 2.612521396353667e-09 8.582940144027194 -0.3504152994995722 S(ph)VQPTSEER ddPTM_A459_Selumetinib_30min_R1 2 SVQPTSEER 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;K7EL40;K7EK18;K7EQD7;K7ER14;K7EIR4;Q9UHD8-8;Q9UHD8-4;K7EKN4;K7ELJ9;K7EJZ2;K7ER52;K7ENQ5;Q9UHD8-9;K7EN52;K7EIE4 Q9UHD8 SEPT9 Septin-9 1 S(1)VQPTSEER;S(1)VQPTSEER 130.1 0.0039251 10292100.0 1785.23 2244.7 2179.5 1756.2 2106.6 1779.0700000000002 1660.09 2231.5 1460.26 1615.67 True False 1826.8223855471174 1981.8894804672805 1883.5358711365416 1449.5126379569012 1916.0584019504383 1761.174171066317 1534.868074753874 2172.313371066449 2477.95456682937 1823.0569824585116 1.0020654335683616 1.087124264099838 1.0331744368168188 0.7951000171163815 1.0510139948376755 0.9660554705707873 0.8419199671334485 1.191577329709652 1.359230452296497 1.0 10.832143940403109 -7.842136282554156 8.424076787009852 1.2094009768417244 0.9718140498104348 0.40775582856141734 0.11783829264851346 0.24849040746411652 23.03934096804752 0.06351870675838588 0.030440637963319046 1.438347150961949e-08 7.842136282554156 -0.23758692703128959 S(ph)VQPTSEER ddPTM_A459_Selumetinib_30min_R2 1 SVQPTSEER 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;K7EL40;K7EK18;K7EQD7;K7ER14;K7EIR4;Q9UHD8-8;Q9UHD8-4;K7EKN4;K7ELJ9;K7EJZ2;K7ER52;K7ENQ5;Q9UHD8-9;K7EN52;K7EIE4 Q9UHD8 SEPT9 Septin-9 1 S(0.998)VQPT(0.002)SEER 113.38 0.0091489 7458700.0 18368.0 14815.0 18747.0 3413.7 17007.0 22067.0 16791.0 13973.0 19409.0 20551.0 True False 17347.180092929844 15951.26286226685 17540.83843019028 2948.7481710390357 14870.42861549093 25106.52894571856 17571.814770735295 14013.659116645324 23291.342332770913 19957.639232089477 0.8692000036275669 0.7992559980049716 0.8789034728108888 0.1477503494650712 0.7450995802940998 1.2579909203564663 0.8804555772549458 0.7021701792320731 1.1670389499436007 1.0 14.28465345545571 -6.541714230934275 24.93139999481967 0.9782602702137442 0.6660211608198274 0.30101806879545157 0.23939661972764273 324.654776677859 429723.03168303875 0.08174787535959459 0.0817598443428619 2.872670199062116e-07 6.541714230934275 -0.31223910939391675 S(ph)VSCDNVSK ddPTM_A459_Selumetinib_30min_R2 1 SVSCDNVSK 9 0 Q96CB8;A0A087WXN4 Q96CB8 INTS12 Integrator complex subunit 12 1 S(0.858)VS(0.141)CDNVSK 109.72 0.011267 46244000.0 114940.0 102630.0 120160.0 130990.0 142000.0 92378.0 99231.0 124870.0 84130.0 130590.0 True False 108552.09494127604 110501.3909925375 112429.03642031587 113148.93602964599 124160.69050389335 105102.230976009 103845.43812249634 125233.35102665875 100958.3507886039 126819.52738643208 0.8559572581476881 0.8713278882977419 0.8865277984969387 0.8922043660111554 0.9790344835899208 0.8287543183767887 0.8188442289811463 0.9874926488651855 0.7960789073197968 1.0 16.952417379965553 -11.169589469057108 2.716972982327735 1.0128593588437544 0.8827309240375504 0.26633855642918725 0.059752801187558165 37106462.586644 33616163.21075553 3337267.376142568 0.01426148168201982 6.767223669045494e-12 11.169589469057108 -0.13012843480620406 S(ph)VSDPVEDK ddPTM_A459_Selumetinib_30min_R2 1 SVSDPVEDK 9 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 S(0.999)VS(0.001)DPVEDK 103.31 0.015352 6334000.0 63688.0 52652.0 72971.0 79598.0 73781.0 77210.0 98345.0 104190.0 78412.0 76671.0 True False 60148.47592326416 56690.23909713629 68276.12530481756 68756.6150857913 64511.97116949122 87844.97665740385 102918.23736692056 104493.17565041684 94096.59101433522 74457.30901481818 0.8078250036043293 0.7613791022967811 0.9169835199285745 0.9234367451032598 0.8664289916340157 1.1798032700848928 1.3822449230127052 1.4033971551351803 1.2637656700111002 1.0 16.184125855782774 -6.840422247140867 3.311174182166525 1.2954716348116655 0.8533363859826437 0.7487514854018741 0.11316185210951397 0.11271504214746868 2.468725558859829 0.04138278990560638 0.03685676117989615 1.4440351104728509e-07 6.840422247140867 -0.4421352488290218 S(ph)VSEINSDDELSGK ddPTM_A459_Selumetinib_30min_R1 4 SVSEINSDDELSGK 14 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.911)VS(0.066)EINS(0.023)DDELSGK;S(0.996)VS(0.004)EINSDDELSGK;S(0.987)VS(0.013)EINSDDELSGK;S(0.604)VS(0.317)EINS(0.078)DDELSGK 293.38 2.727399999999999e-94 90263600.0 10028.400000000001 11259.470000000001 11640.5 13414.099999999999 10459.0 9003.15 10673.73 9848.04 5913.870000000001 8404.54 True False 10262.04220813044 9941.206018014405 10059.784036689565 11071.579248842765 9512.985296686427 8912.586485206151 9868.60195263068 9586.837988257785 10035.405458024741 9483.344576152222 1.0821121309813428 1.0482805868947933 1.0607844053232989 1.1674762168491146 1.0031255555775906 0.9398146839057862 1.0406246312558616 1.0109131763877712 1.0582137322375471 1.0 13.211180241723888 S(ph)VSEINSDDELSGK ddPTM_A459_Selumetinib_30min_R2 2 SVSEINSDDELSGK 14 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.631)VS(0.365)EINS(0.004)DDELSGK;S(0.989)VS(0.011)EINSDDELSGK 274.38 8.8187e-45 84650800.0 119784.0 107423.0 125376.0 124506.0 119022.0 83662.0 98162.0 94203.0 78506.0 106014.0 True False 113126.88481334435 115661.99868061361 117309.44465906735 107548.06801517024 104069.39228981959 95185.68109197935 102726.72750431304 94477.11513385389 94209.39364091479 102953.10036254844 1.098819602469173 1.1234435706482941 1.1394454780474135 1.044631658846996 1.0108427227867849 0.9245538090332763 0.9978012040682773 0.917671394073161 0.9150709722112033 1.0 16.651627750840433 -6.211299898924321 1.614298208217496 0.9484884427131859 1.1217229394485269 0.8340196657342931 0.03240820066045477 0.13816577340893546 0.7149982881273979 0.011389579219726073 0.01603609551210809 6.147522133938667e-07 6.211299898924321 0.17323449673534097 S(ph)VSENSLVAMDFSGQTGR ddPTM_A459_Selumetinib_30min_R1 1 SVSENSLVAMDFSGQTGR 18 0 A0A2R8YCL1;Q13322-3;Q13322-2;Q13322-4;Q13322 A0A2R8YCL1 GRB10 Growth factor receptor-bound protein 10 1 S(0.99)VS(0.01)ENSLVAMDFSGQTGR 204.78 4.7611000000000006e-11 18390000.0 2282.6 2931.9 2221.9 2386.9 2319.3 2229.9 2708.8 2862.6 1288.0 2397.6 True False 2335.7801388335674 2588.631784996668 1920.17818402307 1970.072722662186 2109.519724505672 2207.469230587204 2504.4730351326098 2786.674548964739 2185.641928201985 2705.3553146016975 0.863391261852589 0.9568546397676365 0.7097693133538626 0.728212191584984 0.7797569927764743 0.8159627752675452 0.9257464339767647 1.0300586151934035 0.8078945920357865 1.0 11.40160237111708 -7.277605357508227 4.367844007256571 0.9456109032388662 0.8053965564757408 0.37101104784943095 0.0843937500516679 0.2393427378573024 11.604558247690957 0.037358114269134865 0.02592103337015056 5.2770917184173954e-08 7.277605357508227 -0.14021434676312539 S(ph)VSGFLHFDTATK ddPTM_A459_Selumetinib_30min_R1 2 SVSGFLHFDTATK 13 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 S(0.849)VS(0.151)GFLHFDTATK;S(0.798)VS(0.202)GFLHFDTATK 128.9 0.0011775 30869000.0 13081.4 21563.0 10105.400000000001 9520.5 13301.2 15256.2 19134.9 18335.5 7583.8 13131.6 True False 13386.171168026558 19038.393935633274 8733.14218498885 7857.923396918737 12098.108808517594 15102.736479521282 17691.53908740362 17849.18297790225 12869.1547011632 14817.168772615814 0.9034230070164323 1.2848874321266335 0.5893934474937553 0.5303255647220049 0.816492610307347 1.0192727579261456 1.1939891728911154 1.2046284450029359 0.8685299397376902 1.0 13.854982186982719 -6.84418024548056 4.3365510423021965 1.085803964443257 0.8208205607479707 0.23369834447675963 0.21005926807170766 0.3378587779400829 11.785405512520962 0.0827346300420461 0.07355841096514239 1.4315936208629077e-07 6.84418024548056 -0.2649834036952864 S(ph)VSGFLHFDTATK ddPTM_A459_Selumetinib_30min_R2 1 SVSGFLHFDTATK 13 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 S(0.998)VS(0.002)GFLHFDTATK 105.99 0.0071115 2417000.0 5722.3 4577.1 7710.1 9904.9 8614.2 7356.4 8624.9 7842.4 6994.4 6662.8 True False 5404.277474181861 4928.148852303851 7214.04056012216 8555.835533094454 7532.007184074912 8369.67732524965 9025.97493991512 7865.220085620793 8393.475439864642 6470.427651966606 0.835227246925371 0.7616419064365862 1.1149248470353488 1.3222983075151167 1.1640663630302168 1.2935276886537461 1.3949580190687685 1.2155641804031696 1.2972056703722743 1.0 12.659645352518535 -5.399137247231038 3.4014952440828203 1.2544938989554875 0.7966664334581198 0.7377576048429235 0.10357512316517606 0.1078023815013288 2.274559606385848 0.026628915027314924 0.06206044027311369 3.988988210679141e-06 5.399137247231038 -0.45782746549736764 S(ph)VSGSPEPAAK ddPTM_A459_Selumetinib_30min_R1 1 SVSGSPEPAAK 11 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 S(0.99)VS(0.008)GS(0.002)PEPAAK 169.89 0.00039503 6311100.0 4007.5 4870.9 4651.4 4902.3 4337.7 3821.2 4132.2 3305.3 2317.7 3479.2 True False 4100.8669527624315 4300.612763580025 4019.7654283113116 4046.2053325681104 3945.355800883137 3782.7621973720034 3820.504827146696 3217.632706872477 3932.9676218895506 3925.7892102778724 1.0445968270599446 1.0954772488346673 1.023938172173739 1.0306730993031883 1.0049841164558806 0.9635673223281019 0.9731813458411017 0.8196142315661233 1.0018285270113039 1.0 11.938766996067574 -6.509962867338 1.0685433609728885 0.9337822180070069 1.061454828767915 0.4477698963115919 0.05097560172567965 0.41061050032121693 0.9995654105928189 0.024092605681874803 0.028169368596805414 3.0905596675116414e-07 6.509962867338 0.1276726107609082 S(ph)VSGTDVQEECR ddPTM_A459_Selumetinib_30min_R2 1 SVSGTDVQEECR 12 0 P49321-4;P49321;P49321-3;E9PPR5 P49321-4 NASP Nuclear autoantigenic sperm protein 1 S(0.845)VS(0.153)GT(0.002)DVQEECR 132.24 0.0019111 3513300.0 8070.7 5181.4 8754.8 6726.7 10432.0 5544.6 7520.0 8079.2 11225.0 7491.7 True False 7622.162803571917 5578.796719173096 8191.52569950552 5810.511855795265 9121.43889673672 6308.318321132509 7869.694900597307 8102.7091344164355 13470.313652705105 7275.395155225765 1.047663067221452 0.7668032594993774 1.1259217574761857 0.7986524074395732 1.2537379347958826 0.8670756964453504 1.0816862497076423 1.1137139580104358 1.851488938443386 1.0 12.828809893233172 -8.021854402735936 20.20503067605029 1.4446983399227897 0.9940070582368936 0.34163635868986375 0.23760471492929017 64.50017239063548 59628.47702581295 0.14206221786581985 0.055324577602438 9.509235374251851e-09 8.021854402735936 -0.4506912816858961 S(ph)VSPLLSTHVLGK ddPTM_A459_Selumetinib_30min_R2 2 SVSPLLSTHVLGK 13 0 Q96H12;X6RL08;X6R907;Q96H12-2 Q96H12 MSANTD3 Myb/SANT-like DNA-binding domain-containing protein 3 1 S(0.997)VS(0.003)PLLSTHVLGK;S(0.6)VS(0.4)PLLSTHVLGK 151.16 0.00047295 18176200.0 160161.0 143136.0 228934.0 239879.0 225443.0 180038.0 181091.0 179666.0 198107.0 238534.0 True False 151259.89279528186 154114.07094521934 214204.63568449288 207207.06638564405 197120.83485400872 204836.60027775788 189512.09032500884 180188.79831469248 237733.93557206722 231646.90363423797 0.6529761046757427 0.6652973492301018 0.924703211326814 0.894495299245685 0.8509538947486013 0.8842621984759503 0.8181075911303418 0.7778597317199804 1.0262771996617768 1.0 17.821567872795974 -5.253880064588507 24.218880969215597 0.8841305760041774 0.6591366669164657 0.6308943523048083 0.07225932381638495 236.16500644261956 756628.3241031441 0.01794028627253637 0.045437768528366965 5.573396434277995e-06 5.253880064588507 -0.22499390908771177 S(ph)VSPLVWCR ddPTM_A459_Selumetinib_30min_R1 1 SVSPLVWCR 9 0 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 S(0.619)VS(0.381)PLVWCR 95.775 0.022075 12928000.0 2192.1 2198.2 3440.0 2690.6 2527.6 2420.2 2802.2 2324.8 1456.8 1946.1 True False 2243.171664915913 1940.8337220845451 2972.8668945674235 2220.737218817242 2298.9790262840256 2395.854985365781 2590.827797935837 2263.138751985339 2472.083199537772 2195.9008916192724 1.0215268245835005 0.883843951925062 1.3538256238764996 1.0113103133628474 1.0469411598028646 1.0910578863142868 1.1798473272741117 1.0306197154082326 1.1257717545325285 1.0 11.100597226803016 S(ph)VSPQTLEAYIR ddPTM_A459_Selumetinib_30min_R2 2 SVSPQTLEAYIR 12 0 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0 A0A2R8Y7K2 SPAST Spastin 1 S(0.977)VS(0.018)PQT(0.006)LEAYIR;S(0.801)VS(0.172)PQT(0.027)LEAYIR 115.37 0.0052724 2231420.0 11344.3 10240.0 12325.2 12534.8 10853.1 6584.7 10642.2 11763.4 9428.2 11212.7 True False 10713.829220831009 11025.375073210422 11532.210050663114 10827.538616263912 9489.636550054964 7491.682655044774 11137.083387119244 11797.62954646429 11314.103445918421 10888.960216906706 0.9839166465312472 1.0125278129028255 1.0590735773611946 0.9943592777070277 0.8714915254553793 0.6880071655889457 1.0227866724893797 1.0834486775097902 1.0390435101738749 1.0 13.41057857772442 -10.287938088005662 9.334933455722082 1.0000003092911622 0.9704605678286335 0.005150614732221448 0.10961609502195431 0.0 0.0 0.11785437688933005 0.028583884962121223 5.153020995945983e-11 10.287938088005662 -0.02953974146252869 S(ph)VSPTFLNPSDENLK ddPTM_A459_Selumetinib_30min_R2 1 SVSPTFLNPSDENLK 15 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 S(0.971)VS(0.029)PTFLNPSDENLK 268.13 8.4377e-45 35775000.0 30924.0 29700.0 32223.0 29319.0 29702.0 23644.0 33079.0 31912.0 22242.0 28196.0 True False 29205.367878580295 31977.894499448197 30149.807261749706 25325.701621903965 25970.56922075098 26900.746381137884 34617.23904479499 32004.858636684 26691.021493404616 27381.908217994016 1.066593593334302 1.1678475526564627 1.1010849580576991 0.9249063805297976 0.9484572446154218 0.9824277463416543 1.2642376407516507 1.1688322954662456 0.9747684960781738 1.0 14.740935369633522 -10.237908719561519 15.259688205712838 1.0000000280786716 1.0692723982915633 0.0342652927128646 0.1051526150192806 0.0 0.0 0.11124719708833057 0.026981408479358385 5.7821756496761307e-11 10.237908719561519 0.06927237021289168 S(ph)VSPTTEMVS(ph)NESVDYR ddPTM_A459_Selumetinib_30min_R2 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 2 S(0.764)VS(0.235)PT(0.001)T(0.001)EMVS(0.5)NES(0.5)VDYR 125.23 0.022973 4756800.0 17128.0 8860.5 13175.0 15798.0 12095.0 8650.8 23152.0 12907.0 11530.0 10886.0 True False 16176.094328816554 9540.071859002053 12327.33484385539 13646.285146929924 10575.517969328097 9842.369175856345 24228.61387481768 12944.557233131127 13836.322175117142 10571.692894775242 1.5301328263906653 0.9024166662765016 1.1660700860831688 1.2908325357875474 1.0003618223297752 0.9310116434351452 2.291838602953741 1.2244545279525292 1.3088085619622332 1.0 13.367918800294227 S(ph)VSPTTEMVSNESVDYR ddPTM_A459_Selumetinib_30min_R1 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 S(0.586)VS(0.249)PT(0.164)TEMVSNESVDYR 208.49 4.6396e-09 20275000.0 1918.2 1458.7 2474.7 1597.5 2120.5 1643.8 1910.6 2142.0 884.8 1569.1 True False 1962.8903278325383 1287.9147258687685 2138.6493325540705 1318.5266137889482 1928.7011494046822 1627.264864450983 1766.4819037671155 2085.1872018034223 1501.4409767648408 1770.509269328297 1.1086586000067808 0.727426141269163 1.2079289104007007 0.7447160185098473 1.0893482360227351 0.9190942361280838 0.9977253067064091 1.1777330048063002 0.8480277413822654 1.0 10.78994868149962 -7.518145442167163 24.93760954663835 1.0252740283525366 0.9615731310386482 0.011143478882916558 0.1605013462563172 862.1827745014897 4542523.155573539 0.06752844288374574 0.04032573537388693 3.0328753254885294e-08 7.518145442167163 -0.0637008973138884 S(ph)VSPTTEMVSNESVDYR ddPTM_A459_Selumetinib_30min_R2 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 S(0.359)VS(0.284)PT(0.179)T(0.179)EMVSNESVDYR 121.27 0.0014343 3214300.0 15640.0 7564.6 9942.4 9422.4 10073.0 7683.1 11952.0 9639.7 6372.2 9946.2 True False 14770.791411880598 8144.780495977308 9302.716808466632 8139.052865453388 8807.539686237442 8741.377284762322 12507.791682438707 9667.749931061751 7646.8180541441 9659.027362668883 1.5292214068021115 0.8432298812462238 0.9631111352288582 0.8426368991260926 0.9118454017717819 0.9049956022018137 1.2949328346226656 1.000903048315877 0.7916757833918393 1.0 13.237662205638047 -4.754533732502303 24.956037817119814 0.9555755129202741 1.5292224133443775 0.631327532437399 0.13264947687379297 162.2982620263251 586470.2625765563 0.03458605458804132 0.3338576271123706 1.759811970453307e-05 4.754533732502303 0.5736469004241034 S(ph)VSQDLIK ddPTM_A459_Selumetinib_30min_R1 2 SVSQDLIK 8 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(0.987)VS(0.013)QDLIK;S(0.998)VS(0.002)QDLIK 103.08 0.015702 35589000.0 6037.4 7714.5 5337.0 6167.5 5491.9 5528.200000000001 6254.200000000001 7042.8 3839.3 4674.7 True False 6178.059673264604 6811.282753626251 4612.2647140425415 5090.461903313516 4995.158614673696 5472.591327203998 5782.440658714693 6856.002065761496 6515.011688622577 5274.743280433997 1.1712531482207573 1.2913012807451418 0.8744055338486638 0.9650634415130591 0.9469955880511977 1.0375085641615762 1.0962506327395944 1.2997792880637398 1.2351334164051548 1.0 12.364885164821729 -7.560812712091199 7.813716138074935 1.2008669905974214 1.044525195996933 0.158107955704185 0.13156444397769068 0.37586238781826903 65.10471425978335 0.06574813198566855 0.037993500715843835 2.7490794279719603e-08 7.560812712091199 -0.15634179460048836 S(ph)VSQDLIK ddPTM_A459_Selumetinib_30min_R2 4 SVSQDLIK 8 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(0.999)VS(0.001)QDLIK;S(0.962)VS(0.038)QDLIK;S(0.99)VS(0.01)QDLIK;S(0.999)VS(0.001)QDLIK 111.86 0.011421 55998500.0 276453.0 227530.0 247769.0 288704.0 255736.0 209352.0 269520.0 257651.0 239392.0 255352.0 True False 261088.84898904237 244980.81937573955 231827.81229048973 249382.01715782087 223608.15737115243 238188.33769176048 282053.21404374816 258400.72175358105 287277.0891713484 247979.32427582683 1.0528653941271082 0.9879082463473767 0.9348675054563347 1.0056564912663195 0.9017209721986079 0.960516923688461 1.1374061723388722 1.0420252676636965 1.1584719412002702 1.0 17.91986031275779 -7.249256864304429 24.703196408173387 1.0879779509317111 0.9709436218145929 0.47996976753690423 0.056276336405560685 522.3460952164903 1059192.5395306475 0.02088146561960612 0.016051236574515824 5.633043898183149e-08 7.249256864304429 -0.1170343291171182 S(ph)VSSFPVPQDNVDTHPGSGK ddPTM_A459_Selumetinib_30min_R2 1 SVSSFPVPQDNVDTHPGSGK 20 0 Q676U5-4;Q676U5-3;Q676U5;C9JAY7;E7EVC7;Q676U5-5;Q676U5-2 Q676U5-4 ATG16L1 Autophagy-related protein 16-1 1 S(0.929)VS(0.057)S(0.015)FPVPQDNVDTHPGSGK 107.98 0.00028765 8455700.0 41191.0 36859.0 39458.0 61163.0 59084.0 45937.0 54891.0 50853.0 44122.0 67300.0 True False 38901.76912063772 39685.96677963508 36919.31523862211 52832.493887939934 51661.339702338235 52264.40477543269 57443.54026445308 51000.97381083264 52947.63287168415 65356.874133600395 0.5952207726629641 0.6072194747030024 0.5648880202433313 0.8083693504059186 0.7904499777136497 0.7996772408147228 0.878921169746106 0.7803459771741548 0.8101310470181043 1.0 15.996051363954175 -3.7804210358753307 0.19046552656326918 0.9830171683017068 5.794884843922763e-15 0.7824903414424836 0.060440509937557625 11.55786146495566 0.28608148910687475 0.14778420340038417 2.8520197475557807 0.0001657978765823966 3.7804210358753307 -0.983017168301701 S(ph)VSSSSYR ddPTM_A459_Selumetinib_30min_R1 2 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(0.985)VS(0.015)SSSYR;S(0.511)VS(0.026)S(0.043)S(0.42)SYR 114.86 0.010127 185065000.0 2402.3 2604.6000000000004 1994.21 2439.17 2011.8200000000002 2298.9 2194.0 2108.0 1681.19 1496.1100000000001 True False 2458.2689159379142 2299.652221154312 1723.4072354114267 2013.2147483916046 1829.8512362156696 2275.775153234194 2028.5048136004668 2052.088992250985 2852.8566407405992 1688.1502918454903 1.456190795222698 1.3622319246471393 1.0208849554072543 1.1925565858184066 1.083938583581484 1.3480880015406156 1.2016138749014462 1.2155843008548937 1.689930484578982 1.0 10.72122763399639 S(ph)VSSSSYR ddPTM_A459_Selumetinib_30min_R2 2 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(1)VSSSSYR;S(1)VSSSSYR 98.044 0.019779 241530000.0 198500.0 240100.0 267120.0 397830.0 303840.0 331870.0 130333.0 144030.0 217532.0 256070.0 True False 187468.16465845914 258514.89795681852 249933.79001826522 343644.8677049709 265668.90283593605 377582.0800840904 136393.74274994014 144449.10345454986 261044.47835191508 248676.5937502387 0.7538633283948911 1.0395626466416097 1.0050555472433775 1.3818947031666144 1.0683309547932918 1.5183659804481617 0.5484784100224922 0.5808713288055933 1.0497348158713249 1.0 17.923911197232535 -7.280059214300192 24.998530842824007 0.7598437665465615 1.1270938217550164 0.3028211878091812 0.24530490399230195 994.2010134680716 1334784.3137984606 0.10328509410343072 0.06977452425567256 5.2473590974813226e-08 7.280059214300192 0.3672500552084549 S(ph)VSTMNLSK ddPTM_A459_Selumetinib_30min_R2 1 SVSTMNLSK 9 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 S(1)VSTMNLSK 88.441 0.031191000000000007 4012800.0 18983.0 19647.0 18016.0 14366.0 16534.0 17090.0 16817.0 17346.0 12041.0 18205.0 True False 17928.0008549699 21153.86172493802 16856.870174337666 12409.326017267716 14456.85110416458 19443.99237242626 17599.023822253315 17396.47398821512 14449.536453650077 17679.374347729496 1.0140630829095112 1.1965277338931817 0.9534766243864585 0.7019097946111088 0.8177241354709606 1.0998122439170699 0.9954551261885294 0.9839982821818177 0.8173103962531221 1.0 14.10977959990101 -5.4103839582197635 6.546138137137156 0.9158892888327765 1.1026952072363834 0.29214510825445217 0.11568534970056898 0.30674263900405185 15.644080146602377 0.03257164904725301 0.06845884337601013 3.8870134355290576e-06 5.4103839582197635 0.18680591840360683 S(ph)VSTPSEAGSQDSGDGAVGSR ddPTM_A459_Selumetinib_30min_R1 1 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 S(0.691)VS(0.134)T(0.134)PS(0.041)EAGSQDSGDGAVGSR 209.73 9.0353e-18 4415700.0 1446.2 1281.1 1393.8 1601.4 1325.7 1041.7 1343.8 1102.1 926.19 1013.1 True False 1479.8936461846608 1131.1082164327677 1204.5296155953715 1321.7455520010144 1205.7906690713446 1031.2214437879236 1242.4360841004136 1072.8687278746736 1571.6767837588468 1143.1412534296721 1.2945851107591984 0.9894737094293442 1.0537014668847975 1.156239920513314 1.0548046144373766 0.9020945055512914 1.0868613833792065 0.9385268221716558 1.3748753962325084 1.0 10.15878796733214 -4.7510243449676235 24.960242119325056 1.0581863192006762 1.2945856122281376 0.23586928593444367 0.12551909384683965 628.5808052701693 1506328.4763410424 0.029721787653498973 0.4113830433898321 1.7740900290742136e-05 4.7510243449676235 0.23639929302746143 S(ph)VSTTGSLQR ddPTM_A459_Selumetinib_30min_R2 1 SVSTTGSLQR 10 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.984)VS(0.001)TTGS(0.015)LQR 101.43 0.016365 12319000.0 27054.0 23414.0 28028.0 29915.0 28671.0 19038.0 19060.0 19880.0 20011.0 22710.0 True False 25550.446985742805 25209.778512123907 26224.708994579054 25840.525393746608 25069.09265800793 21660.311690242885 19946.32776667351 19937.847508688832 24013.759154056286 22054.3032923338 1.1585243318307084 1.1430775290410995 1.189097141132312 1.1716772482551703 1.1366984631394856 0.9821353866014952 0.9044188565959808 0.9040343394397473 1.08884687200269 1.0 14.428772565163383 -6.7459968408465585 3.92275666144414 0.9629980665457548 1.1642907397819358 0.7699949849499661 0.05030854413850668 0.09902473751489572 3.3471388115186356 0.01786138453294041 0.016872346459489523 1.794746682166573e-07 6.7459968408465585 0.20129267323618094 S(ph)VSVDSGEQR ddPTM_A459_Selumetinib_30min_R2 1 SVSVDSGEQR 10 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 S(0.64)VS(0.36)VDSGEQR 144.7 0.00095209 18866000.0 56086.0 54035.0 57939.0 73995.0 61678.0 43233.0 48641.0 68037.0 65654.0 93594.0 True False 52968.96465004703 58179.31075009036 54211.26781921347 63916.75335150528 53929.458231684024 49187.95331990075 50902.902880312984 68234.97640586829 78786.63452603118 90891.69803358364 0.5827701076777715 0.6400948822475914 0.5964380575130515 0.7032188278393549 0.5933375588577693 0.5411710242416887 0.5600390792732779 0.7507283710406213 0.8668188209765896 1.0 16.471860905511676 -8.239722827101966 1.7990595851976021 0.9867609774767782 0.6052307347168997 0.886763845341602 0.04781772427863318 0.1102444400536235 0.6573409303673605 0.047121641841520664 0.014058241598612778 5.758073084850111e-09 8.239722827101966 -0.38153024275987846 S(ph)VTPPEEQQEAEEPK ddPTM_A459_Selumetinib_30min_R1 2 SVTPPEEQQEAEEPK 15 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 S(0.993)VT(0.007)PPEEQQEAEEPK;S(0.673)VT(0.327)PPEEQQEAEEPK 188.0 2.4421e-05 17120700.0 6549.0 6210.3 7149.9 7452.6 5760.3 6093.5 6818.3 6385.1 3893.2 6207.200000000001 True False 6701.578957864295 5483.195188909856 6178.982851589423 6151.14331262818 5239.281882063562 6032.204922455324 6303.990141555179 6215.746406272184 6606.4760519223355 7003.954583248106 0.9568278717701817 0.782871322727368 0.8822134378723941 0.8782386064210553 0.7480462387055954 0.8612570014207416 0.9000615390386618 0.887462408899518 0.9432494133704906 1.0 12.77395401338856 -8.28521722281452 1.0157257003837383 0.9982945845679851 0.8487865850966163 0.42769815393080035 0.05444975720654479 0.46734324175772274 1.0035512126149133 0.05035025681389899 0.017254842814763943 5.1854061351506375e-09 8.28521722281452 -0.14950799947136884 S(ph)VTPPEEQQEAEEPK ddPTM_A459_Selumetinib_30min_R2 2 SVTPPEEQQEAEEPK 15 0 G8JLH2;B4DIG0;P30305-2;P30305;P30305-4;P30305-3 G8JLH2;P30305-3 CDC25B M-phase inducer phosphatase 2 1 S(0.608)VT(0.392)PPEEQQEAEEPK;S(0.841)VT(0.159)PPEEQQEAEEPK 157.37 0.00015532 20168600.0 86761.0 69221.0 74469.0 68885.0 72114.0 56133.0 81496.0 80075.0 58181.0 75870.0 True False 81939.17095180134 74530.02811940438 69677.74561571665 59502.74416674689 63054.39461266027 63864.811225360034 85285.72548126042 80308.00499287005 69818.82571296544 73679.43596606617 1.1121036674268145 1.0115444987082958 0.945687825946543 0.8075895721317885 0.8557936659789391 0.8667928898746406 1.1575241363212885 1.089964980593184 0.9476026084825245 1.0 16.168974396840888 -7.250217978124948 24.934204154552223 1.0562700173135835 0.9281432705725104 0.2580334196771856 0.09539350792558086 997.7845214181325 2217102.661189496 0.0401821747520651 0.030818522982408836 5.620591494867324e-08 7.250217978124948 -0.12812674674107305 S(ph)VVADTDQK ddPTM_A459_Selumetinib_30min_R1 2 SVVADTDQK 9 0 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 S(1)VVADTDQK;S(1)VVADTDQK 149.94 0.0013723 15360400.0 5140.2 6577.7 5655.4 6254.2 5016.9 5461.9 5693.200000000001 5680.9 3268.8 4527.6 True False 5259.956658911903 5807.579826110231 4887.427742888549 5162.021375874078 4563.122280805633 5406.958245008411 5263.757340378385 5530.22407783616 5546.914856293978 5108.761562558663 1.029595254055567 1.1367881931842543 0.956675641060989 1.010425190657898 0.8931953908845662 1.0583696613745268 1.0303392076380433 1.0824979811871298 1.0857650701388128 1.0 12.318757888134773 S(ph)VVGTPAYLAPEVLLNQGYNR ddPTM_A459_Selumetinib_30min_R2 2 SVVGTPAYLAPEVLLNQGYNR 21 0 Q9BZL6-2;Q9BZL6;Q9BZL6-3 Q9BZL6-2 PRKD2 Serine/threonine-protein kinase D2 1 S(0.996)VVGT(0.004)PAYLAPEVLLNQGYNR;S(0.891)VVGT(0.109)PAYLAPEVLLNQGYNR 178.57 3.6371e-14 17403300.0 23280.8 12367.2 19338.8 26973.7 27003.4 14998.7 19762.2 26948.9 6255.4 17209.6 True False 21986.946336426463 13315.724473184368 18094.562662493405 23299.835527772113 23610.991478541073 17064.6347803575 20681.18145805641 27027.31683736945 7506.65479047942 16712.714132089295 1.3155820271113452 0.796742190881939 1.082682472726012 1.3941383394475226 1.412756258015969 1.0210570614375853 1.2374519958040475 1.6171710126648773 0.4491583312650723 1.0 14.028658424554644 -8.27022646462513 24.99763171920768 0.7245792007604923 1.2192524164030123 0.3990477029937386 0.24982789325443563 746.5366036590901 2123732.676457078 0.22887847289361385 0.06272258646689027 5.3675183195499695e-09 8.27022646462513 0.49467321564252 S(ph)VVGTPAYLAPEVLR ddPTM_A459_Selumetinib_30min_R1 2 SVVGTPAYLAPEVLR 15 0 O94806;H0Y5M6;Q15139;F8WBA3 O94806;Q15139 PRKD3;PRKD1 Serine/threonine-protein kinase D3;Serine/threonine-protein kinase D1;Serine/threonine-protein kinase 1 S(1)VVGTPAYLAPEVLR;S(0.967)VVGT(0.033)PAYLAPEVLR 176.19 1.9229e-05 9706000.0 783.5999999999999 1048.76 793.67 883.8 744.9100000000001 698.3399999999999 691.8199999999999 669.98 302.34000000000003 590.1 True False 801.8563553798226 925.9706916447036 685.8939733172466 729.4609209807023 677.533022024542 691.3153336419878 639.6354604125223 652.2099539982521 513.0488979600837 665.8450830607536 1.2042686441324355 1.3906698648103035 1.0301104427539396 1.0955414998748954 1.017553540997947 1.0382525173335404 0.9606370561035744 0.9795220699087788 0.7705229204392452 1.0 9.379042745603194 -5.45614829857189 0.5304111757749427 0.9174635892363404 1.4124860338987004 0.6404025958161474 0.0923286109812976 1.3622095062899453 0.4836988867894431 0.05971960680985846 0.3855433087537456 3.4982569162364463e-06 5.45614829857189 0.49502244466236 S(ph)VVGTPAYLAPEVLR ddPTM_A459_Selumetinib_30min_R2 3 SVVGTPAYLAPEVLR 15 0 O94806;H0Y5M6;Q15139;F8WBA3 O94806;Q15139 PRKD3;PRKD1 Serine/threonine-protein kinase D3;Serine/threonine-protein kinase D1;Serine/threonine-protein kinase 1 S(0.996)VVGT(0.004)PAYLAPEVLR;S(0.97)VVGT(0.03)PAYLAPEVLR;S(1)VVGTPAYLAPEVLR 184.0 2.1012e-05 22988600.0 16262.7 16261.399999999998 17784.0 17653.0 19814.0 6310.7 12203.0 18948.800000000003 9675.5 13387.199999999999 True False 15358.884238746201 17508.597091357817 16639.79680175516 15248.630946876452 17324.78818059254 7179.941642169128 12770.46367978577 19003.937870857288 11610.87035605775 13000.676751877196 1.1813911330830142 1.3467450522396622 1.2799177396170938 1.1729105521121943 1.3326066412728073 0.5522744530304855 0.9822922239753261 1.4617652783431654 0.8930973808252891 1.0 13.66629910443124 S(ph)VVSDLEADDVK ddPTM_A459_Selumetinib_30min_R1 4 SVVSDLEADDVK 12 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 S(0.999)VVS(0.001)DLEADDVK;S(0.998)VVS(0.002)DLEADDVK;S(0.995)VVS(0.005)DLEADDVK;S(0.993)VVS(0.007)DLEADDVK 234.52 1.5926e-10 15084500.0 5312.779999999999 6963.200000000001 4129.5 6238.9 4142.28 5679.98 5074.6 4673.490000000001 2298.19 5042.79 True False 5436.557437129677 6147.945306896145 3568.736581719818 5149.393233657506 3767.6115053789335 5622.844558209208 4691.818836416099 4549.533863565017 3899.8605768435714 5690.081217434227 0.9554446113127943 1.0804670569655555 0.6271855260668904 0.9049771061052573 0.662136683363164 0.9881835325972135 0.824560960929787 0.7995551714842647 0.6853787191814632 1.0 12.47423352966378 -5.2388442543906475 24.99692067748205 0.8091195066373174 1.0179558581714394 0.3042580505579191 0.12483946835199224 910.7634177351714 1007571.5142630601 0.029676841454842364 0.07839754765845185 5.769733390424446e-06 5.2388442543906475 0.20883635153412206 S(ph)VVSDLEADDVK ddPTM_A459_Selumetinib_30min_R2 2 SVVSDLEADDVK 12 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 S(0.995)VVS(0.005)DLEADDVK;S(1)VVSDLEADDVK 180.48 0.00010399 13668100.0 58612.0 61129.0 66980.0 51104.0 56050.0 30332.0 50534.0 53825.0 44558.0 45481.0 True False 55354.57968242619 65817.39773928514 62670.579722309994 44143.547040682824 49008.49790664236 34509.95767351861 52883.93113122134 53981.62183879157 53470.84505454204 44167.8453561706 1.253277791480329 1.490165463325911 1.4189186548932349 0.9994498641423001 1.109596755545502 0.7813366804567771 1.1973400718274576 1.2221927830864838 1.2106283343312725 1.0 15.430708834526852 -5.7551374814042555 24.99854194238744 1.078004149783671 1.3977252094292212 0.5278775826861237 0.1355526393183523 121.91014489817616 483590.3367579167 0.03895755505870336 0.06540121571751589 1.757367209105737e-06 5.7551374814042555 0.3197210596455502 S(ph)VVSFDK ddPTM_A459_Selumetinib_30min_R1 4 SVVSFDK 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 S(0.999)VVS(0.001)FDK;S(0.611)VVS(0.389)FDK;S(0.995)VVS(0.005)FDK;S(0.515)VVS(0.485)FDK 123.21 0.007414100000000002 58122000.0 22234.6 25826.5 17672.4 18454.2 18564.0 16938.2 20977.8 20175.300000000003 12014.400000000001 19060.199999999997 True False 22752.622918999758 22802.7213735859 15272.585147544583 15231.520398237244 16884.889477740395 16767.8170866551 19395.427656676322 19640.185505389618 20387.55930294249 21506.762332070106 1.057928783872404 1.0602582118826556 0.7101294426251532 0.7082200548394284 0.78509676245235 0.7796532470929638 0.9018292645450664 0.9132097710543294 0.9479604130158308 1.0 14.39250273466668 -9.602103421688174 10.082112002762079 0.9999948910508056 0.8662117858753204 0.0853774181257344 0.12164077804803303 0.0 0.0 0.13038670715343337 0.031623421515887276 2.499750007250093e-10 9.602103421688174 -0.1337831051754852 S(ph)VVSFDK ddPTM_A459_Selumetinib_30min_R2 1 SVVSFDK 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 S(0.912)VVS(0.088)FDK 110.41 0.015429 7824400.0 53499.0 41274.0 57395.0 50306.0 53506.0 54398.0 58953.0 59950.0 40411.0 37511.0 True False 50525.739753465474 44439.583083172554 53702.268186951034 43454.23601730962 46784.09793029094 61890.830724121915 61694.43131315337 60124.44457474324 48494.32917768074 36427.95996471745 1.3870043725314987 1.219930600731274 1.4742046559556103 1.1928814037183944 1.284290912134635 1.6989924987308296 1.6936010518543432 1.6505026532635148 1.3312392246134632 1.0 15.152758583216617 -6.733858507285427 24.906558466059877 1.5291944329176017 1.308997259591817 0.10421607903418983 0.2110010552217729 330.4680022265949 298424.1011188435 0.06696087319741408 0.06694592882596404 1.8456166213165507e-07 6.733858507285427 -0.2201971733257848 S(ph)WASPVYTEADGTFSR ddPTM_A459_Selumetinib_30min_R1 2 SWASPVYTEADGTFSR 16 0 E9PMS6;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(1)WASPVYTEADGTFSR;S(1)WASPVYTEADGTFSR 328.41 1.7282999999999991e-134 208572000.0 5415.0 5943.7 6567.8 7109.0 6170.3 5811.3 6328.5 5925.7 3384.6 4670.0 True False 5541.158964244183 5247.808840848832 5675.928834343006 5867.546602457361 5612.197454454945 5752.843598238226 5851.136149895419 5768.5311866136935 5743.418998596615 5269.439989652125 1.0515650572215731 0.9958949814694215 1.0771408053776348 1.1135047773539064 1.065046279201568 1.0917371883037639 1.1103905085522563 1.094714276648308 1.089948649168653 1.0 12.363433932087894 -5.377949870841905 6.163668179079605 1.0863698740621566 1.0242477032971324 0.3095318803393231 0.03303159553048679 0.21621686019582753 10.048267767691662 0.008026300833007677 0.016961361529390838 4.188419078470492e-06 5.377949870841905 -0.06212217076502413 S(ph)WASPVYTEADGTFSR ddPTM_A459_Selumetinib_30min_R2 3 SWASPVYTEADGTFSR 16 0 E9PMS6;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(1)WASPVYTEADGTFSR;S(0.999)WAS(0.001)PVYTEADGTFSR;S(0.994)WAS(0.006)PVYTEADGTFSR 246.38 3.3738999999999997e-29 46352000.0 56335.0 55100.0 57471.0 66853.0 62051.0 49667.0 54255.0 55592.0 50281.0 67444.0 True False 53204.12622687295 59325.992825575595 53773.37842969359 57747.50607214246 54255.59863702167 56508.17841786398 56777.965004242935 55753.763516248946 60338.604968522515 65496.71647944339 0.8123174578312096 0.9057857555988394 0.8210087668527741 0.8816855130480766 0.828371276505902 0.8627635315977935 0.8668826172692657 0.8512451694238391 0.9212462580083722 1.0 15.999134961961923 -8.548220111646074 2.28740715613621 0.9998698738027967 0.8547769092516047 0.7447823502860331 0.02699548901611551 0.14325025767129934 1.7604113687820704 0.023302373735052954 0.006389949007019725 2.829957336891805e-09 8.548220111646074 -0.14509296455119203 S(ph)WDSSSPVDRPEPEAASPTTR ddPTM_A459_Selumetinib_30min_R2 1 SWDSSSPVDRPEPEAASPTTR 21 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 S(0.96)WDS(0.017)S(0.017)S(0.005)PVDRPEPEAASPTTR 76.959 0.001489 8547400.0 1810.8 1630.4 2425.7 4188.1 4858.5 1362.9 1582.2 2118.8 2228.3 3885.6 True False 1710.1629852067379 1755.4464374377235 2269.6331029024673 3617.673555124523 4248.131794458909 1550.6271038256148 1655.7754350698233 2124.965357213779 2674.0222639040335 3773.4126319987754 0.4532138814357191 0.46521454413742824 0.6014802313576407 0.9587272604237407 1.1258063214275813 0.41093494272961295 0.43880052264328157 0.5631415284917265 0.708648251513274 1.0 11.881654155705492 -12.26476047765417 1.1995473935925798 3.7982615510569206 0.639458691504157 0.18979940307360377 0.2253991165180147 136758.50204693165 5970.290156950849 1028500.5949031416 0.07269575224012213 5.435500278687083e-13 12.26476047765417 -3.1588028595527637 S(ph)WEGSPGEQPR ddPTM_A459_Selumetinib_30min_R2 1 SWEGSPGEQPR 11 0 A0A2R8Y4Z8;M0QYB4;Q9Y3X0 A0A2R8Y4Z8;Q9Y3X0 CCDC9 Coiled-coil domain-containing protein 9 1 S(0.995)WEGS(0.005)PGEQPR 114.76 0.0054716 0.0 14660.0 15533.0 15227.0 18147.0 18355.0 11577.0 13480.0 12042.0 8011.1 15880.0 True False 13845.25588862977 16724.33115353296 14247.311397904063 15675.347294678919 16049.080804218043 13171.62666445751 14106.84671011326 12077.04022633958 9613.543848836154 15421.503138804972 0.8977890004633267 1.0844812599006446 0.9238600977912261 1.0164604029574265 1.0406949737496018 0.8541078353973083 0.9147517322495201 0.7831299009984473 0.6233856558797884 1.0 13.912655771599454 -7.240646752740637 1.4991313416182763 0.788082233237542 0.9924350162002326 0.3419783056026623 0.10531072123803942 0.40626800453307305 1.785447121746872 0.05838191943209665 0.035364812732694685 5.745836280973714e-08 7.240646752740637 0.20435278296269055 S(ph)WGQQAQEYQEQK ddPTM_A459_Selumetinib_30min_R1 4 SWGQQAQEYQEQK 13 0 Q5VZK9-2;Q5VZK9 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(1)WGQQAQEYQEQK;S(1)WGQQAQEYQEQK;S(1)WGQQAQEYQEQK;S(1)WGQQAQEYQEQK 290.95 1.2085999999999996e-60 42260800.0 5086.780000000001 5912.619999999999 7427.9 6996.83 5379.33 5597.57 5715.59 5126.96 3221.79 5227.88 True False 5205.292076849124 5220.367701697532 6419.231978534123 5774.96498726568 4892.770551297849 5541.263527986916 5284.458444652091 4990.976366086867 5467.14231976853 5898.929321863503 0.8824130266413744 0.8849686810704811 1.088202897217669 0.9789852822717561 0.8294336623365741 0.9393676760033467 0.8958334905058165 0.8460817368312171 0.9268024791389483 1.0 12.526237408253438 -6.216956397374942 24.98912540017857 0.899691921038175 0.962634389240755 0.11398656361564563 0.06978413859160609 893.0262616241109 501673.3706703801 0.02106036328156951 0.02718861672078411 6.067972482183157e-07 6.216956397374942 0.06294246820257998 S(ph)WGQQAQEYQEQK ddPTM_A459_Selumetinib_30min_R2 3 SWGQQAQEYQEQK 13 0 Q5VZK9-2;Q5VZK9 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(1)WGQQAQEYQEQK;S(1)WGQQAQEYQEQK;S(1)WGQQAQEYQEQK 235.26 6.659099999999998e-14 37402300.0 113030.0 100782.0 110100.0 112983.0 111253.0 94506.0 110226.0 106369.0 84487.5 119986.0 True False 106748.24509494012 108511.65533479431 103016.28586781614 97594.52049345402 97276.40352556085 107523.34365994824 115351.72740867538 106678.51617966402 101387.3607779887 116521.69241893297 0.9161233662067475 0.9312571168693636 0.884095345074799 0.8375652504477048 0.8348351410467064 0.922775334170115 0.989959251483825 0.9155249461715714 0.8701157584758425 1.0 16.8302390355992 -6.983605177346374 23.948410980368845 0.9396471034341027 0.881107817029566 0.3161197252824225 0.04401971455795215 205.85770100507784 300700.3280774043 0.016593822637140147 0.014629463892531482 1.0384720750174989e-07 6.983605177346374 -0.05853928640453676 S(ph)WHDVQVSSAYK ddPTM_A459_Selumetinib_30min_R2 2 SWHDVQVSSAYK 12 0 O43399-2;O43399-4;O43399-3;O43399-6 O43399-2 TPD52L2 Tumor protein D54 1 S(1)WHDVQVSSAYK;S(1)WHDVQVSSAYK 146.77 0.0006475 7124300.0 53188.0 52347.0 57537.0 62427.0 64664.0 46386.0 53723.0 53667.0 42639.0 54785.0 True False 50232.02388843386 56361.846577865865 53835.132061548946 53924.33490741833 56540.3302165053 52775.25044981655 56221.22595010496 53823.16208494988 51167.99143320204 53203.214701475445 0.9441539232222524 1.0593691921458803 1.0118774281520244 1.0135540720610419 1.0627239450426915 0.9919560452491412 1.0567261069761227 1.0116524421870554 0.9617462350782168 1.0 15.699225799970607 -8.073408590930985 6.841088629764752 0.9820467760054379 1.0224249215784664 0.16166262345212823 0.03485343391307122 0.4200428349078344 32.8332564166486 0.022063907484294997 0.008272601284969401 8.444839677916719e-09 8.073408590930985 0.040378145573028545 S(ph)WHDVQVSSAYVK ddPTM_A459_Selumetinib_30min_R1 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 1 S(1)WHDVQVSSAYVK 109.1 0.0060488 8809800.0 1452.1 1608.3 2211.0 1751.0 2202.0 1596.8 2106.5 1787.9 829.74 1636.9 True False 1485.9311047052595 1419.9994883216152 1910.7583441536565 1445.2207203408122 2002.8294887946763 1580.737641778398 1947.6050090471192 1740.479084082323 1408.0081781881315 1847.0120597562238 0.8045053614329831 0.7688089965741927 1.0345131933820975 0.782464149439045 1.084361890446464 0.8558350409401388 1.0544625297704726 0.9423214509557878 0.7623167216211714 1.0 10.850977570849086 -5.241295864849336 24.748463007305347 0.9381525013683862 0.7866571390656121 0.2525908136098177 0.1051681782447327 957.1824638264587 1175996.198243964 0.025147735317697734 0.06633306579207475 5.737254762712791e-06 5.241295864849336 -0.15149536230277416 S(ph)WHDVQVSSAYVK ddPTM_A459_Selumetinib_30min_R2 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 1 S(1)WHDVQVSSAYVK 161.94 0.00024045 6638100.0 52104.0 55695.0 56813.0 55243.0 72853.0 41505.0 46762.0 47817.0 42650.0 43631.0 True False 49208.26826883802 59966.62741234912 53157.71343331738 47718.808100509545 63700.554825916464 47221.93700512297 48936.52565714511 47956.1395534695 51181.19174056771 42371.25966304782 1.161359578642709 1.4152665719458488 1.2545700518711855 1.1262069733113302 1.5033906315858252 1.1144803666600795 1.1549462075545252 1.1318082099714462 1.20792235462386 1.0 15.370798399037621 -8.304011438732156 0.3806943941373098 0.9920198402152034 1.2996174527122997 0.30562311856903557 0.1183947429155033 1.5407020006180316 0.6546978458556014 0.17638465051499472 0.11227548042088885 4.965792420491785e-09 8.304011438732156 0.3075976124970963 S(ph)WHEESPFEK ddPTM_A459_Selumetinib_30min_R2 2 SWHEESPFEK 10 0 Q9BY84 Q9BY84 DUSP16 Dual specificity protein phosphatase 16 1 S(1)WHEESPFEK;S(0.999)WHEES(0.001)PFEK 145.23 0.00090917 8579400.0 28427.0 29166.0 30013.0 29666.0 41186.0 30937.0 29549.0 30730.0 26394.0 32275.0 True False 26847.14114229728 31402.93841652883 28081.99625568364 25625.43962329556 36011.84647248838 35198.29093187544 30923.087050232687 30819.41921237465 31673.537509977603 31343.13688947925 0.856555654814145 1.00190796241169 0.8959535975835827 0.8175773763058504 1.148954764785405 1.1229983474848118 0.9865983471683857 0.9832908340045443 1.0105414024659816 1.0 14.935861954651049 -6.25573150192223 24.99947177210643 1.0425019308458898 0.900988954990264 0.5334713051776814 0.06812691059530811 435.38703374364843 1906915.6903160226 0.02192549120581626 0.027546827001120367 5.549687105928713e-07 6.25573150192223 -0.14151297585562583 S(ph)WITIPR ddPTM_A459_Selumetinib_30min_R1 2 SWITIPR 7 0 Q03188;H0Y8J2;Q03188-2 Q03188 CENPC Centromere protein C 1 S(1)WITIPR;S(1)WITIPR 98.582 0.021764 16996600.0 3410.7 4664.5 4319.0 5207.0 3796.6000000000004 4458.3 4129.0 3493.2 2309.77 3507.3 True False 3490.16267393308 4118.378171532783 3732.5035225688084 4297.695197495494 3453.1982003441717 4413.453549812521 3817.5462057230275 3400.548988487259 3919.5109910738333 3957.4961189950513 0.8819118374320367 1.0406524852331593 0.9431477404750112 1.0859632121602258 0.8725714685529651 1.1152136141407647 0.9646367528700035 0.8592678012153753 0.9904017270569393 1.0 11.950372220214856 -8.51305192676874 24.180396615428354 1.000000086075235 0.9738109297931326 0.01322579802775059 0.08359428437987539 2523.073277750409 6208397.097425764 0.07702209719262376 0.019887019867165564 3.068655060247224e-09 8.51305192676874 -0.026189156282102388 S(ph)WITIPR ddPTM_A459_Selumetinib_30min_R2 1 SWITIPR 7 0 Q03188;H0Y8J2;Q03188-2 Q03188 CENPC Centromere protein C 1 S(1)WITIPR 80.455 0.04486 2357800.0 12812.0 11649.0 12563.0 13188.0 12929.0 9648.5 12140.0 13992.0 8970.5 12446.0 True False 12099.960330499627 12542.440842561347 11754.71025756017 11391.771649431066 11304.743433273496 10977.493294637492 12704.534054953641 14032.714403499709 10764.850656711908 12086.65164140848 1.0011011063680824 1.03771012970965 0.9725365309023146 0.9425084785602013 0.9353081207820872 0.9082327860785656 1.0511210575001861 1.1610092538304058 0.8906396060784837 1.0 13.561127010456508 -7.289372527869702 24.37353748705171 1.0391099317431292 0.9672842965810282 0.1347178337601489 0.07059114599230466 942.5439867484594 822428.0283350426 0.02966227360605749 0.020003885871153603 5.136029057575407e-08 7.289372527869702 -0.07182563516210094 S(ph)WPASPR ddPTM_A459_Selumetinib_30min_R1 2 SWPASPR 7 0 Q86YD1 Q86YD1 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 S(1)WPASPR;S(1)WPASPR 112.41 0.014575 5632600.0 5952.4 6549.4 6126.9 6629.4 6384.700000000001 6050.5 6396.9 6509.6 3831.0 5348.4 True False 6091.079338645812 5782.593203266544 5294.900632652662 5471.699739250364 5807.205012310338 5989.6374634144495 5914.376682826266 6336.944261839192 6500.927194830589 6034.919237827714 1.009305857892195 0.958188995640645 0.8773772148371909 0.9066732334963139 0.962267229014428 0.9924967058168017 0.9800258213488806 1.0500462412352336 1.0772185904463927 1.0 12.559118748937317 -7.259106692669818 1.2654057699077426 1.0457819421564987 0.937631254264606 0.5232628805611776 0.03933380476483795 0.3730418870097316 1.164750049366553 0.027075926744483 0.015614961160533998 5.5067239667654695e-08 7.259106692669818 -0.10815068789189264 S(ph)WSLATFR ddPTM_A459_Selumetinib_30min_R2 2 SWSLATFR 8 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(0.722)WS(0.278)LATFR;S(0.979)WS(0.021)LATFR 100.25 0.017997 5221600.0 32120.0 36449.0 38376.0 36199.0 33845.0 24332.5 16965.4 22566.5 18609.1 36276.0 True False 30334.898986547632 39244.52109799284 35906.92994062957 31268.633753241982 29593.08852186102 27684.08100655715 17754.324716302348 22632.164778914805 22331.439981697506 35228.61762363281 0.8610868388488151 1.1139954884765615 1.0192545822899879 0.8875918461320972 0.8400297973091273 0.7858406850453742 0.5039744932935437 0.6424369250223493 0.633900547000648 1.0 15.104460243917996 -6.4756870173751695 1.432376196081781 0.6699228744460869 1.001439821337718 0.4456745205628647 0.13558182033775554 0.3217596659105004 1.348663820586161 0.05368481596030383 0.061995570434493254 3.3443597087891e-07 6.4756870173751695 0.33151694689163114 S(ph)WSPPPEVSR ddPTM_A459_Selumetinib_30min_R1 2 SWSPPPEVSR 10 0 Q9NR19;Q9NR19-2;F8WCJ4;C9JXD9;C9IYL0;B4DEH9;C9JY31 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 S(0.601)WS(0.399)PPPEVSR;S(0.595)WS(0.404)PPPEVS(0.001)R 111.86 0.008594 15815700.0 9024.1 10706.3 11698.2 12783.7 11154.8 8883.6 10030.6 9907.0 5081.7 7917.299999999999 True False 9234.343972158062 9452.801418776162 10109.648693612973 10551.266774769181 10145.850309539897 8794.23904966343 9273.983766317608 9644.234177528706 8623.273747316793 8933.562576032708 1.0336686952786676 1.0581222595492292 1.1316480527864117 1.1810816440774154 1.1357003684912401 0.9844044830734091 1.038105871805073 1.0795507498209744 0.9652670671890329 1.0 13.12501990074964 -6.757392591003204 24.999924813047283 1.0199775683976995 1.1106397289354377 0.48751911482050936 0.0482177052974984 104.44113621163606 645207.9456834608 0.01767398468067503 0.017064646893770716 1.7482655871239912e-07 6.757392591003204 0.09066216053773823 S(ph)WSPPPEVSR ddPTM_A459_Selumetinib_30min_R2 2 SWSPPPEVSR 10 0 Q9NR19;Q9NR19-2;F8WCJ4;C9JXD9;C9IYL0;B4DEH9;C9JY31 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 S(0.988)WS(0.012)PPPEVSR;S(0.922)WS(0.078)PPPEVSR 103.31 0.014356 151942000.0 184793.0 150034.0 172584.0 184135.0 197713.0 147266.0 156166.0 162369.0 135189.0 164173.0 True False 174522.94484499068 161541.1253646539 161480.13333525127 159055.49534940763 172874.52536335395 167550.55475235375 163428.02843705847 162841.46690836496 162230.5774962632 159432.89891731934 1.0946482566029043 1.013223283661347 1.0128407275526843 0.9976328375732073 1.0843089885294335 1.0509158140519301 1.0250583759491882 1.0213793264388504 1.0175476868196112 1.0 17.282589834050853 -8.11773494298391 1.294299381094191 1.0033510422969836 1.0387100665339388 0.17150123996561994 0.029230426071947802 0.9038003476288071 2.790833993655265 0.028060312075546937 0.00921280985736452 7.625442612538317e-09 8.11773494298391 0.03535902423695525 S(ph)WSSEEESNQATGTSR ddPTM_A459_Selumetinib_30min_R2 1 SWSSEEESNQATGTSR 16 0 F6UZG9;Q8NFZ0;Q8NFZ0-2 F6UZG9 FBXO18 F-box only protein 18 1 S(0.995)WS(0.001)S(0.004)EEESNQATGTSR 69.431 0.045226 4362800.0 24022.0 22808.0 33918.0 47049.0 40013.0 25197.0 24400.0 28062.0 29933.0 36071.0 True False 22686.953407685145 24557.300260721026 31735.752807126155 40640.845035948 34986.2092192414 28667.65803440752 25534.648347682745 28143.65577408582 35920.43639789948 35029.53650628678 0.6476521150547767 0.7010455378509992 0.905971245192768 1.160187918234492 0.9987631213151335 0.8183853083315137 0.7289462235134062 0.8034264389720045 1.0254328198562608 1.0 15.096284278779766 -5.237423486003423 4.394215700328249 0.9234789481582539 0.6652431063029699 0.4264681986393598 0.11909717761428121 0.21904978817723975 10.584411188923537 0.0350848342200182 0.09412145578252193 5.788639636119751e-06 5.237423486003423 -0.25823584185528403 S(ph)WSSTPTAGGIEGSVK ddPTM_A459_Selumetinib_30min_R1 1 SWSSTPTAGGIEGSVK 16 0 B5MCH3;Q8N3C7 B5MCH3 CLIP4 CAP-Gly domain-containing linker protein 4 1 S(0.998)WS(0.002)STPTAGGIEGSVK 90.561 0.022829 0.0 902.21 1208.9 1073.6 1303.6 1986.0 821.1 1428.6 891.11 554.4 544.17 True False 923.2297376049384 1067.3614259976375 927.8110168626708 1075.9507316026738 1806.366650656778 812.8404794991493 1320.839551827542 867.4748680667813 940.7763082260709 614.0195201646669 1.503583692839843 1.7383183937074085 1.5110448225063786 1.752307046059589 2.9418717016884885 1.323802343093527 2.1511360933172305 1.41278060318692 1.53216026092098 1.0 9.262140710512064 -8.45782509978769 1.211337300924392 1.0214136827229359 1.843487057403088 0.247255395007566 0.4393799570332623 0.6694990560188773 2.141803689604527 0.4163919148499902 0.1307940079928188 3.484776266041578e-09 8.45782509978769 0.8220733746801521 S(ph)WSSTPTAGGIEGSVK ddPTM_A459_Selumetinib_30min_R2 1 SWSSTPTAGGIEGSVK 16 0 B5MCH3;Q8N3C7 B5MCH3 CLIP4 CAP-Gly domain-containing linker protein 4 1 S(0.977)WS(0.019)S(0.003)T(0.001)PTAGGIEGSVK 116.78 0.0019945 0.0 5857.8 7531.4 8435.8 6241.5 12660.0 6271.0 8671.4 4434.0 7108.4 9272.3 True False 5532.246926631338 8109.034162732128 7893.049812204581 5391.396932811947 11069.537618164002 7134.773327529845 9074.63728205313 4446.902205911784 8530.278625290779 9004.584606671368 0.6143811367525578 0.900545057539274 0.8765590148774585 0.5987391055016063 1.2293224064953248 0.792348968795717 1.0077796676295163 0.49384867821855305 0.9473261674914818 1.0 13.136444008909358 -4.7556616988869145 24.628649616436793 0.8605626618942569 0.6143806590372856 0.12925236956359232 0.1985360410046565 341.14789862987965 1454038.7651320277 0.04724282524258287 0.40681184219435335 1.7552472493064555e-05 4.7556616988869145 -0.24618200285697134 S(ph)WSTATSPLGGERPFR ddPTM_A459_Selumetinib_30min_R2 2 SWSTATSPLGGERPFR 16 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;Q9UPQ0-5;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(0.996)WS(0.002)T(0.002)ATSPLGGERPFR;S(0.961)WS(0.018)T(0.018)AT(0.004)SPLGGERPFR 102.03 0.0028378 6744800.0 8598.6 13577.0 13898.7 13555.4 14208.5 12407.8 7334.3 11422.400000000001 9596.7 9094.800000000001 True False 8120.724234923053 14618.312243064252 13004.472773760373 11709.131135630718 12423.501204398357 14116.861823205998 7675.359482639742 11455.637292919886 11516.308154201792 8832.209492871749 0.9194442502158812 1.655113848336854 1.4723917932716555 1.3257306843866032 1.4066130580830367 1.5983386529270345 0.8690191835728454 1.2970296166735447 1.3038988900225148 1.0 13.108558676744515 -7.250146131013648 24.979691483462343 1.1422393770566457 1.4087611827799866 0.27127345142299886 0.22180691074784864 1024.1307179966116 2265292.8385454486 0.08289638146271015 0.06362310439871094 5.6215214092098785e-08 7.250146131013648 0.26652180572334094 S(ph)WTSPK ddPTM_A459_Selumetinib_30min_R2 1 SWTSPK 6 0 O75494-2;O75494 O75494-2 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.999)WT(0.001)SPK 93.195 0.042231 185960000.0 360310.0 300540.0 348830.0 313830.0 301670.0 272270.0 360320.0 345090.0 299090.0 268690.0 True False 340285.4126352112 323590.4516115881 326386.65757738746 271085.81261305365 263771.5176359824 309772.721079023 377075.59396053525 346094.15476727526 358916.35727283487 260932.2215595402 1.3041141895063504 1.2401322062777533 1.2508484219642906 1.0389127528705633 1.0108813547804572 1.1871769581678062 1.445109353328727 1.3263756875204566 1.3755156612229142 1.0 17.99331558269281 -7.0303883522626744 23.787762227682677 1.3142617872200275 1.1631309366008429 0.13000183824845202 0.13852446098003035 619.5387658790161 484967.7932755712 0.053462408731879456 0.04148395380755489 9.324201446262297e-08 7.0303883522626744 -0.15113085061918463 S(ph)Y(ph)MDMQRRAS(ph)PDLST(ph)GY(ph)WKLSPK ddPTM_A459_Selumetinib_30min_R1 1 SYMDMQRRASPDLSTGYWKLSPK 23 3 A0A0G2JQE0;A0A0G2JNC7;A0A0G2JS53;Q13075-2;Q13075;E7EQW0;B7ZLE8 A0A0G2JQE0 NAIP Baculoviral IAP repeat-containing protein 1 5 S(1)Y(1)MDMQRRAS(0.675)PDLS(0.561)T(0.824)GY(0.934)WKLS(0.006)PK 47.472 0.017256 33346000.0 841.26 816.87 1232.3 1017.0 1038.2 828.28 1065.9 916.57 385.19 855.54 True False 860.8597211929938 721.2304806474402 1064.9604285393716 839.4000414543725 944.294993309097 819.9482552180683 985.4983048389873 892.2595861610466 653.6392968354985 965.3568926653054 0.8917528094881058 0.747112789194633 1.1031779403356883 0.8695230207937171 0.978182266562517 0.8493731815124139 1.0208642133564432 0.9242795000899195 0.6770960064632997 1.0 9.914918595460792 -10.129775183568377 8.695132254832492 0.9999998188429083 0.9022528851762375 0.06318183188679483 0.11808124142735597 0.0 0.0 0.11046240486198966 0.026791068406219136 7.416940865344088e-11 10.129775183568377 -0.09774693366667087 S(ph)Y(ph)T(ph)S(ph)KKS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 SYTSKKSSK 9 2 Q9Y3E1;H3BPM9 Q9Y3E1 HDGFRP3 Hepatoma-derived growth factor-related protein 3 5 S(0.999)Y(0.999)T(0.999)S(0.999)KKS(0.991)S(0.014)K 41.979 0.047558 0.0 467.27 808.98 1280.1 1942.3 983.22 970.63 1272.7 484.56 720.58 921.69 True False 441.3010040300158 871.0261647193133 1197.739759667498 1677.7553893456136 859.6991135016757 1104.3254719981326 1331.8830718072063 485.96998937677387 864.716134687416 895.0784148617857 0.49303055095810755 0.9731283318387401 1.3381394744643105 1.8744228008276633 0.9604735174341421 1.2337751125063807 1.4880071395899654 0.5429356593878039 0.9660786366085499 1.0 9.805870267432812 -7.761875811183637 24.99999998967964 0.8158804062615455 1.2101103729786178 0.17011153266155954 0.36043452164731016 20.42587619285436 1169780.5241889162 0.19121794251573168 0.10072774996612828 1.7303110801315957e-08 7.761875811183637 0.39422996671707233 S(ph)YDNLTTACDNTVPLASR ddPTM_A459_Selumetinib_30min_R1 2 SYDNLTTACDNTVPLASR 18 0 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 S(1)YDNLTTACDNTVPLASR;S(1)YDNLTTACDNTVPLASR 200.73 1.5359e-10 62585000.0 2558.3 2533.2 3035.9 2814.0 2437.4 2159.9300000000003 2966.7 2620.0 1487.54 2335.3 True False 2617.9034124147524 2236.6117663472687 2623.641455005013 2322.5877253221297 2216.937600357921 2138.203065259529 2742.919430496127 2550.5090890405977 2524.246734377004 2635.0585027483094 0.9934896738286211 0.8487901744931017 0.995667250753109 0.8814178975152622 0.8413238636051923 0.8114442480231194 1.0409330296216652 0.9679136483613064 0.9579471316269711 1.0 11.363619277146181 -7.273449240250698 24.994200140857778 0.989024587233511 0.894709020939672 0.38032895014911305 0.06020366058355231 884.646108091948 1841065.2748551487 0.025587090760324883 0.01739802213731442 5.327834916950534e-08 7.273449240250698 -0.09431556629383908 S(ph)YDNLTTACDNTVPLASR ddPTM_A459_Selumetinib_30min_R2 3 SYDNLTTACDNTVPLASR 18 0 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 S(0.995)Y(0.003)DNLT(0.001)TACDNTVPLASR;S(1)YDNLTTACDNTVPLASR;S(0.99)Y(0.009)DNLT(0.001)TACDNTVPLASR 236.95 7.6302e-25 60860900.0 40515.0 33763.3 47290.0 57065.0 46420.9 32748.7 37094.0 45877.0 39072.9 34313.6 True False 38263.33849439531 36352.83654387944 44247.41288545891 49292.648557384266 40589.0915338886 37259.53616190026 38818.94450036659 46010.49447465379 46888.571788042864 33322.87721056032 1.1482603453662554 1.0909273024106965 1.3278389079631006 1.4792434712619287 1.218054829942042 1.1181368261349405 1.1649337557221655 1.380747952342862 1.4070985374931386 1.0 15.024225352827903 -11.708759281399978 2.423802862589611 0.2707718962151116 1.2584002593489803 0.2735451660242375 0.12684208911615327 10003405.701318046 3663970.103645777 39616963.81951932 0.03534228005437917 1.95542299765692e-12 11.708759281399978 0.9876283631338687 S(ph)YDSSMESR ddPTM_A459_Selumetinib_30min_R2 1 SYDSSMESR 9 0 Q9HCG8;B7WP74 Q9HCG8 CWC22 Pre-mRNA-splicing factor CWC22 homolog 1 S(0.946)YDS(0.016)S(0.035)MES(0.003)R 93.345 0.02469 53313000.0 73157.0 73755.0 96121.0 79469.0 94631.0 70558.0 51064.0 67279.0 51659.0 67383.0 True False 69091.22681067445 79411.77134029623 89936.67950863173 68645.18510832866 82742.60776812631 80276.72403824756 53438.5771813964 67474.77075136204 61992.24347305955 65437.47770794051 1.0558357264172267 1.2135518379043513 1.374390986004009 1.0490194230087035 1.2644528894805784 1.2267698397016054 0.8166356505961705 1.0311334286525276 0.947350748293544 1.0 15.997829520121657 -7.244917283423409 24.80877218510352 0.9513744085084425 1.2024307990115335 0.5826998332160445 0.10298299308281034 515.0681398090572 773402.104111506 0.03869387334653369 0.029882763626520266 5.689612860042812e-08 7.244917283423409 0.25105639050309103 S(ph)YDVPPPPMEPDHPFYSNISK ddPTM_A459_Selumetinib_30min_R1 14 SYDVPPPPMEPDHPFYSNISK 21 0 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 S(0.989)Y(0.011)DVPPPPMEPDHPFYSNISK;S(0.999)Y(0.001)DVPPPPMEPDHPFYSNISK;S(0.998)Y(0.002)DVPPPPMEPDHPFYSNISK;S(1)YDVPPPPMEPDHPFYSNISK;S(0.854)Y(0.146)DVPPPPMEPDHPFYSNISK;S(0.997)Y(0.003)DVPPPPMEPDHPFYSNISK;S(0.842)Y(0.158)DVPPPPMEPDHPFYSNISK;S(0.997)Y(0.003)DVPPPPMEPDHPFYSNISK;S(0.998)Y(0.002)DVPPPPMEPDHPFYSNISK;S(1)YDVPPPPMEPDHPFYSNISK;S(0.996)Y(0.004)DVPPPPMEPDHPFYSNISK;S(1)YDVPPPPMEPDHPFYSNISK;S(1)YDVPPPPMEPDHPFYSNISK;S(0.995)Y(0.005)DVPPPPMEPDHPFYSNISK 183.75 6.2318999999999986e-15 1026064300.0 72060.34 78806.11 85093.02000000002 88802.01999999999 83160.75999999998 71774.71 74141.9 68285.68000000001 38067.03 56347.340000000004 True False 73739.20571698665 69579.45400523342 73537.8552665011 73294.41422736677 75638.8839412247 71052.72158362252 68549.31679101384 66474.52194325103 64596.96960413258 63580.06995857059 1.1597849100360513 1.0943595068481695 1.156618030059091 1.1527891409230304 1.189663427399683 1.1175313526694952 1.0781573036280279 1.0455245171414014 1.0159940001045078 1.0 15.956286983455778 -7.569886181443131 1.407819761173814 1.0101385597563346 1.148023761093021 0.8545112430717002 0.023647438009260682 0.16727098309563723 0.629701889438898 0.018373866285424225 0.008287616568437284 2.6922402854989962e-08 7.569886181443131 0.13788520133668647 S(ph)YDVPPPPMEPDHPFYSNISK ddPTM_A459_Selumetinib_30min_R2 14 SYDVPPPPMEPDHPFYSNISK 21 0 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 S(0.998)Y(0.002)DVPPPPMEPDHPFYSNISK;S(0.999)Y(0.001)DVPPPPMEPDHPFYSNISK;S(0.941)Y(0.059)DVPPPPMEPDHPFYSNISK;S(0.999)Y(0.001)DVPPPPMEPDHPFYSNISK;S(0.975)Y(0.025)DVPPPPMEPDHPFYSNISK;S(1)YDVPPPPMEPDHPFYSNISK;S(0.677)Y(0.323)DVPPPPMEPDHPFYSNISK;S(0.879)Y(0.121)DVPPPPMEPDHPFYSNISK;S(0.911)Y(0.089)DVPPPPMEPDHPFYSNISK;S(0.998)Y(0.002)DVPPPPMEPDHPFYSNISK;S(0.996)Y(0.004)DVPPPPMEPDHPFYSNISK;S(0.986)Y(0.014)DVPPPPMEPDHPFYSNISK;S(0.943)Y(0.057)DVPPPPMEPDHPFYSNISK;S(1)YDVPPPPMEPDHPFYSNISK 150.95 1.7571e-06 607976400.0 809391.9 865595.9 944472.4 1088339.0 1084065.2 827019.5 781226.1 846832.4 740414.6 951394.8 True False 764409.138450494 931984.3222005012 883706.0740477986 940105.350710506 947875.2379101497 940933.9291894555 817554.66162015 849296.5420833504 888518.2089124448 923925.5601034462 0.8273492708275197 1.0087223066933582 0.9564689107084077 1.0175120067089043 1.0259216530431543 1.0184088089132473 0.8848707048743336 0.9192261571248878 0.9616772684727576 1.0 19.817417094048047 -4.753367496625681 24.99332482690469 0.9750259912482621 0.8273489996675001 0.5039448963700384 0.04449808890546948 284.18644757035423 879869.7892349529 0.012241889407415437 0.13256435864649246 1.7645440452652555e-05 4.753367496625681 -0.14767699158076197 S(ph)YEDLTESEDGAASGDSHK ddPTM_A459_Selumetinib_30min_R1 2 SYEDLTESEDGAASGDSHK 19 0 A0A0A0MSQ9;Q86VX9-5;Q86VX9 A0A0A0MSQ9 MON1A Vacuolar fusion protein MON1 homolog A 1 S(1)YEDLTESEDGAASGDSHK;S(0.99)YEDLT(0.01)ESEDGAASGDSHK 256.67 6.5622e-95 7781600.0 2649.96 3297.04 3824.67 3706.9300000000003 3072.56 2981.16 3474.3599999999997 3239.59 1395.95 2349.79 True False 2711.698912075441 2911.0210240476895 3305.300821408484 3059.5842631941555 2794.6474905045266 2951.1722370767075 3212.286227976716 3153.6655495286404 2368.825193845931 2651.40843539286 1.0227390378177053 1.0979149742413647 1.246620768527025 1.153946793844614 1.0540237608056198 1.1130583269187764 1.2115395670832398 1.1894303070893566 0.8934214594119828 1.0 11.372543211498051 -8.261072219361548 24.99999308743482 0.946710717554906 1.1381641617487843 0.542726064694341 0.06953881322469879 25.095264893962177 1709084.3496766433 0.056810583114008495 0.01842908505917836 5.481857988528077e-09 8.261072219361548 0.19145344419387833 S(ph)YEDLTESEDGAASGDSHK ddPTM_A459_Selumetinib_30min_R2 1 SYEDLTESEDGAASGDSHK 19 0 A0A0A0MSQ9;Q86VX9-5;Q86VX9 A0A0A0MSQ9 MON1A Vacuolar fusion protein MON1 homolog A 1 S(0.989)YEDLT(0.011)ESEDGAASGDSHK 213.72 3.932e-17 8187300.0 64480.0 51614.0 66789.0 80913.0 77104.0 60898.0 63946.0 67627.0 53345.0 63946.0 True False 60896.459733891345 55572.62783483229 62491.868454364914 69892.50981728954 67417.50620149425 69286.1467229967 66919.61570659504 67823.78337374752 64015.490583835555 62099.7128283389 0.9806238541267704 0.8948934754086655 1.0063149346134665 1.1254884545197836 1.085633139526027 1.1157241083307925 1.0776155421455764 1.0921754752913522 1.0308500260024134 1.0 15.922298976463978 -5.532665199333922 5.071345357704853 1.080991445062457 0.9394052925201786 0.6532422099411299 0.040221072561451604 0.0898750726208796 6.738046615241166 0.01034144995653716 0.019575565419129193 2.93315356257157e-06 5.532665199333922 -0.14158615254227835 S(ph)YELPDGQVITIGNER ddPTM_A459_Selumetinib_30min_R1 3 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;Q6S8J3;A5A3E0;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;POTEE;POTEF;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 S(0.998)YELPDGQVIT(0.002)IGNER;S(1)YELPDGQVITIGNER;S(1)YELPDGQVITIGNER 178.99 1.0862e-06 71216000.0 3385.8999999999996 4079.24 2942.25 3036.22 4191.38 3392.75 4365.34 5659.6900000000005 1953.71 3999.9 True False 3464.78488218548 3601.6406844127746 2542.7086106223865 2506.0011739081547 3812.270419048241 3358.6220153705276 4036.0588892446012 5509.576635935948 3315.303176667311 4513.326127325378 0.7676788214368924 0.7980014257350214 0.563377991948747 0.5552448689085149 0.8446698314060042 0.7441567306727878 0.8942537665977157 1.220735324792705 0.7345587451780219 1.0 12.139975314326083 -7.257941883964036 2.3385193622448774 0.9927334682821457 0.6988947880345227 0.44056861013656845 0.14007617992830695 0.2797410278909285 3.0031181660667636 0.06702280222575162 0.044147163114865294 5.521513216358877e-08 7.257941883964036 -0.29383868024762305 S(ph)YELPDGQVITIGNER ddPTM_A459_Selumetinib_30min_R2 3 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;Q6S8J3;A5A3E0;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;POTEE;POTEF;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 S(1)YELPDGQVITIGNER;S(0.999)YELPDGQVIT(0.001)IGNER;S(1)YELPDGQVITIGNER 195.77 1.0593e-06 25731300.0 24441.5 22959.0 22090.5 27518.9 30081.6 21093.7 25376.5 29710.9 26574.3 21349.8 True False 23083.13927707669 24719.881475179514 20669.221280317834 23770.778347249656 26302.48047508391 23999.165705456275 26556.557532580806 29797.353800095738 31889.9025479805 20733.37580055782 1.113332411427938 1.192274799481252 0.9969057368728994 1.1464982150475522 1.2686057846101577 1.157513659922693 1.2808602799678341 1.437168461456916 1.5380950432163834 1.0 14.339667414193404 -7.046383560759517 1.2768070094671489 1.3576357435572877 1.1223600983379876 0.23556032103449498 0.14461125212695758 0.5520230422721414 1.822811502759093 0.08049376559206367 0.056016230742462786 8.987035128031528e-08 7.046383560759517 -0.2352756452193001 S(ph)YESANGR ddPTM_A459_Selumetinib_30min_R2 1 SYESANGR 8 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 1 S(0.999)YES(0.001)ANGR 80.706 0.045499 3247700.0 4605.8 1996.5 4521.3 5897.6 5944.7 3651.3 4576.4 9556.4 5573.0 5944.2 True False 4349.8280744782405 2149.625130240684 4230.404480419231 5094.336706072537 5197.873639707705 4154.233431798711 4789.211667964564 9584.20754185281 6687.75572263034 5772.5755011136325 0.7535333359674692 0.3723857972625881 0.7328452403269755 0.8825067259994691 0.9004427293683629 0.7196499086061819 0.8296490304961174 1.6603000757640753 1.1585393246636884 1.0 12.494999422192857 -7.616905542875786 7.343951344743753 1.304200739227171 0.7300570933500348 0.5863903006561738 0.2054419992470184 0.152049856567861 10.234496128403412 0.0985179622312213 0.056476855748702155 2.4159862436016313e-08 7.616905542875786 -0.5741436458771363 S(ph)YESSEDCSEAAGSPAR ddPTM_A459_Selumetinib_30min_R2 1 SYESSEDCSEAAGSPAR 17 0 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 S(0.996)YES(0.002)S(0.002)EDCSEAAGSPAR 295.22 2.4370999999999998e-76 24444000.0 30667.0 24553.0 28813.0 32355.0 38080.0 29992.0 30723.0 34746.0 28340.0 29233.0 True False 28962.650909727774 26436.136149661692 26959.202949222432 27948.193184511834 33296.04996048068 34123.12575973134 32151.68037646956 34847.105107490024 34008.791885760606 28388.967333544446 1.020207976198749 0.931211616085264 0.9496366187778658 0.9844737519384232 1.1728517479795055 1.2019854529689569 1.1325413847822174 1.2274875904455542 1.1979580477932978 1.0 14.793042750631106 -6.23606668240703 5.1521703900838665 1.1685388583688525 0.9649746077086474 0.668948659241039 0.0630624149555691 0.10043153338533994 7.8132541760614505 0.018055932902130027 0.022726528913001608 5.806752526851189e-07 6.23606668240703 -0.20356425066020511 S(ph)YNTPLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R1 2 SYNTPLLNPVQEHEAEGAAAGGTSIR 26 0 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.883)Y(0.001)NT(0.115)PLLNPVQEHEAEGAAAGGTSIR;S(0.989)Y(0.002)NT(0.009)PLLNPVQEHEAEGAAAGGTSIR 120.31 5.1099e-09 17604300.0 4729.7 3437.4 4995.299999999999 5830.1 4589.4 4017.6 3629.0 3734.0 2235.94 2783.2 True False 4839.892807605857 3034.9476099960953 4316.965697218794 4811.982479531108 4174.289580324379 3977.186591688934 3355.2616082753393 3634.962190258625 3794.2268734036825 3140.4508306637645 1.5411458636284077 0.966405071642096 1.3746324747604348 1.5322585001319855 1.3292007439078748 1.266438102725626 1.0684012548498243 1.1574650858298396 1.2081790411607036 1.0 11.616755966223396 -7.068850997697417 3.6561902049424257 1.1223891292776529 1.3373348881672797 0.3405334261415842 0.15671493396358532 0.3265905188063271 8.482907412053576 0.06324397929191322 0.049363937656767366 8.533928547612439e-08 7.068850997697417 0.21494575888962686 S(ph)YNTPLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R2 2 SYNTPLLNPVQEHEAEGAAAGGTSIR 26 0 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.983)Y(0.009)NT(0.008)PLLNPVQEHEAEGAAAGGTSIR;S(0.84)Y(0.062)NT(0.098)PLLNPVQEHEAEGAAAGGTSIR 145.8 7.074800000000001e-11 17351400.0 22076.8 14168.1 22442.5 21708.6 23599.9 17657.7 20354.5 21534.6 20833.4 20897.1 True False 20849.859836432574 15254.747712378197 20998.573983546466 18751.851230576205 20635.06957621712 20089.88789435875 21301.024581676596 21597.26212075505 25000.662133832204 20293.746425813668 1.027403191059465 0.7516969706970489 1.034731268586083 0.9240211657874975 1.016819129560488 0.9899546132499415 1.049634904010709 1.0642323830992246 1.2319392195632903 1.0 14.308747604969708 -6.877220049099307 0.7870238756910976 1.1092763725076853 0.9157302969827236 0.346108138237035 0.0919627553240939 0.6694066547405709 0.8898109976000406 0.0628191888665985 0.05388239127188081 1.3267220615085622e-07 6.877220049099307 -0.19354607552496172 S(ph)YSAGEASEVSR ddPTM_A459_Selumetinib_30min_R2 1 SYSAGEASEVSR 12 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(0.866)YS(0.134)AGEASEVSR 172.33 0.00022903 13044000.0 16067.0 19923.0 21167.0 22783.0 28096.0 22160.0 13534.0 18419.0 14325.0 24960.0 True False 15174.06046129703 21451.03003745814 19805.138264887064 19679.91609713283 24566.32929857313 25212.338851548615 14163.357817112237 18472.596240570398 17190.400273942145 24239.339946131728 0.6260096394959223 0.884967581012099 0.8170659064521143 0.8118998347673028 1.0134900270868799 1.0401413119160519 0.584312850456661 0.7620915537148681 0.7091942401131884 1.0 14.565062793318743 -10.232720539012549 6.126371630677905 1.0000000023253115 0.8135731735423068 0.14477951112106358 0.14060502277357287 4.5593519795426375e-09 1.038459287769264e-09 0.1423152495992317 0.03451651801375142 5.851665075469543e-11 10.232720539012549 -0.18642682878300465 S(ph)YSCSSPK ddPTM_A459_Selumetinib_30min_R2 1 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(0.84)YS(0.04)CS(0.12)SPK 134.84 0.0027041 12760000.0 38208.0 39017.0 33800.0 43856.0 41368.0 29062.0 32216.0 37221.0 25575.0 41350.0 True False 36084.55231874259 42009.478440571416 31625.34479865747 37882.737144180195 36170.98200538773 33065.02670143077 33714.107834792936 37329.30694773175 30690.714625205605 40156.118059797554 0.8986065900346273 1.0461538731909785 0.787559812219979 0.9433864370995223 0.9007589317155743 0.8234119307098546 0.8395758719652221 0.9296044725275405 0.7642848987420356 1.0 15.293332188515132 -5.257919359420886 24.999421183487115 0.8715173116514803 0.9723802240280168 0.20990645433718014 0.07659589287403915 421.4258466077405 2992961.202398147 0.01829283338858305 0.04458864034801926 5.521799595286369e-06 5.257919359420886 0.10086291237653655 S(ph)YSFDVDNGTSAGR ddPTM_A459_Selumetinib_30min_R2 2 SYSFDVDNGTSAGR 14 0 Q08499-9 Q08499-9 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 S(0.85)YS(0.15)FDVDNGTSAGR;S(0.997)YS(0.003)FDVDNGTSAGR 170.35 0.000161 12420000.0 50674.0 54168.0 63944.0 62317.0 57462.0 38796.0 42987.0 38015.0 41726.0 57530.0 True False 47857.74194409445 58322.51142242795 59829.91265696312 53829.31709717893 50243.1098432022 44139.79684497654 44985.98067712453 38125.617356277944 50072.3659218506 55868.95941910888 0.8566070039909432 1.043916192977811 1.0708972080210155 0.9634923874878483 0.899302767862498 0.7900594051493893 0.8052052722094901 0.6824114455090033 0.8962466178441894 1.0 15.769759329340733 -6.434752358175397 2.4691016083944337 0.8135459542024635 0.9963324638804215 0.34492389910720533 0.09378112206477102 0.2756059880702771 3.3044611402134323 0.03162112173675581 0.03583194576916972 3.674917906012778e-07 6.434752358175397 0.18278650967795806 S(ph)YSLSELSVLQAK ddPTM_A459_Selumetinib_30min_R2 2 SYSLSELSVLQAK 13 0 Q9P0V3-2;Q9P0V3 Q9P0V3-2 SH3BP4 SH3 domain-binding protein 4 1 S(0.951)YS(0.049)LSELSVLQAK;S(0.649)YS(0.346)LS(0.005)ELSVLQAK 175.29 0.0001012 43404000.0 122983.0 111779.0 115656.0 114501.0 116175.0 118758.0 122935.0 107066.0 104708.0 115259.0 True False 116148.09719995597 120352.08987386605 108214.81887673185 98905.76627475805 101580.05788232245 135115.8365222118 128651.72109108127 107377.5443342695 125652.52578596382 111931.173191154 1.0376742589984327 1.075232988653938 0.96679786150302 0.8836302118074703 0.9075224978554088 1.207133211151673 1.1493824054838793 0.9593175991364989 1.122587409777049 1.0 16.772252361913637 -6.744706446781693 24.999954605952574 1.0889976574349054 0.9743463740755304 0.31384031775954213 0.08390978267849544 329.91332651970475 492908.4197550644 0.029838038537971602 0.029760393917507514 1.8000872392505163e-07 6.744706446781693 -0.11465128335937502 S(ph)YSPAHNR ddPTM_A459_Selumetinib_30min_R1 1 SYSPAHNR 8 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.767)YS(0.233)PAHNR 92.051 0.026006 873560.0 408.66 700.61 687.55 637.19 646.63 721.69 366.73 443.76 425.0 653.39 True False 418.18098288606217 618.5822554952478 594.1844864418122 525.9167280376713 588.1424306717986 714.4304538420915 339.06726084398304 431.9900432643724 721.1939592281393 737.258971057559 0.5672104366342313 0.8390298114757752 0.8059372754589692 0.7133405610287408 0.7977419790879443 0.9690359587178421 0.45990252293249 0.5859407077064189 0.9782098116671604 1.0 9.526027662058697 -8.320835480172464 9.891061465624093 0.9905375225918425 0.7266974144125737 0.37069792432651194 0.1412490205979885 0.7819590168343358 125.5948092604593 0.14047299865783422 0.03637102411244979 4.777102059963657e-09 8.320835480172464 -0.26384010817926873 S(ph)YSPDGK ddPTM_A459_Selumetinib_30min_R1 2 SYSPDGK 7 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 S(0.5)YS(0.5)PDGK;S(0.649)YS(0.351)PDGK 112.11 0.014704 1590050000.0 13335.599999999999 20399.5 14255.5 13481.1 13601.3 16681.0 15168.0 16586.7 12552.3 15410.5 True False 13646.293533439462 18011.11705652974 12319.681399856368 11126.878956588542 12371.064816504557 16513.204285136173 14023.865548173133 16146.766834805228 21300.336316280875 17388.587785981596 0.7847844633156977 1.0358010252592231 0.7084923486304219 0.6398954931555083 0.7114473566667624 0.9496575851000882 0.8064982459057976 0.9285841399853355 1.2249606798691766 1.0 14.085853148485366 -8.021380656530289 3.816369319047568 1.1108643140377996 0.8072977900603909 0.5034504051719697 0.12099250658310565 0.19360980172849987 6.0468643774398645 0.08924711388199544 0.033653981050204784 9.519614097349582e-09 8.021380656530289 -0.3035665239774087 S(ph)YSPDGK ddPTM_A459_Selumetinib_30min_R2 2 SYSPDGK 7 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 S(0.878)YS(0.122)PDGK;S(0.788)YS(0.212)PDGK 129.42 0.0046489 663290000.0 681050.0 434540.0 421080.0 590480.0 511370.0 408590.0 834630.0 1383920.0 636300.0 950740.0 True False 643199.9674591615 467867.8207336771 393988.1712372398 510055.60536518384 447127.12889419694 464869.56368927134 873441.9487879705 1387946.9780797104 763577.7797074612 923289.6658808211 0.6966394093077461 0.5067400167284769 0.4267221715964663 0.5524329191734094 0.4842761111894785 0.5034926533546592 0.9460107494593306 1.5032627672222507 0.8270186572260676 1.0 19.81642381349812 -7.3746745825486615 3.93324231570025 1.1387708833177084 0.5217780697486256 0.704480610928814 0.17284205106943315 0.1165797055434579 3.1582137661914054 0.0725463525990438 0.04712650257561156 4.220125996082208e-08 7.3746745825486615 -0.6169928135690828 S(ph)YSPDHR ddPTM_A459_Selumetinib_30min_R2 1 SYSPDHR 7 0 A0A024RAC6;Q14241 A0A024RAC6 TCEB3 Transcription elongation factor B polypeptide 3 1 S(0.968)Y(0.001)S(0.031)PDHR 87.181 0.033928 8946300.0 22746.0 23689.0 25307.0 18087.0 25646.0 18822.0 24760.0 45105.0 25318.0 49324.0 True False 21481.868379452426 25505.870127859547 23678.77517217824 15623.519398184679 22424.120201851027 21414.55965089566 25911.38906100923 45236.24808246528 30382.30744402564 47899.887960857435 0.4484742928210367 0.5324828765508239 0.4943388425360813 0.32617027018835243 0.4681455668575978 0.4470690968712722 0.5409488448529015 0.944391521738656 0.6342876515463519 1.0 15.547734661011857 -7.641372898679225 4.9181376764750055 0.8398853702514688 0.45631843998202753 0.7592683084830745 0.10233522063965864 0.1005967379783947 3.8820342373860184 0.04824201486456063 0.02691020904580701 2.2836371598109167e-08 7.641372898679225 -0.3835669302694413 S(ph)YSSPDITQAIQEEEKR ddPTM_A459_Selumetinib_30min_R1 1 SYSSPDITQAIQEEEKR 17 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 S(0.496)Y(0.002)S(0.496)S(0.006)PDITQAIQEEEKR 94.201 0.0035513000000000007 4424900.0 882.7 1025.2 1082.7 1193.4 860.92 1010.3 1014.1 960.63 375.71 989.04 True False 903.2651925647901 905.1691073974499 935.6752868453924 984.9950928924764 783.0499380077716 1000.1372992790044 937.6056205434058 935.1509718339962 637.5524292273036 1115.9929180654253 0.8093825488880352 0.8110885765893222 0.8384240362988918 0.8826176913380115 0.7016621031656629 0.8961860627330354 0.8401537369688206 0.837954216999048 0.5712871640193751 1.0 10.1241121567178 S(ph)YT(ph)LNIEGANT(ph)HLDFRFS(ph)HLGPFK ddPTM_A459_Selumetinib_30min_R2 1 SYTLNIEGANTHLDFRFSHLGPFK 24 1 H0YAK3;D6RER2;D6RIH8;Q13634-2;Q13634 H0YAK3 CDH18 Cadherin-18 4 S(0.559)Y(0.514)T(0.928)LNIEGANT(0.999)HLDFRFS(1)HLGPFK 48.65600000000001 0.025949 3946800.0 27455.0 27466.0 31404.0 27446.0 32411.0 36290.0 30872.0 27198.0 23394.0 31972.0 True False 25929.161011073007 29572.553882890374 29383.500830089928 23707.807453009154 28339.240421983686 41288.61809217957 32307.60917170748 27277.14167712873 28073.453682973995 31048.88528676778 0.8351076301642086 0.9524513878600794 0.9463625041190256 0.7635638843083619 0.9127297215420846 1.329793894719167 1.0405400668434346 0.8785224147403943 0.9041694548350875 1.0 14.922253853466371 -6.545290968670008 24.999918596422138 1.0344812916994102 0.8792225766604194 0.2661296251974653 0.12447202020509265 352.76516787361794 393492.35735918226 0.044186718710419924 0.04418961048089092 2.8491087816671746e-07 6.545290968670008 -0.1552587150389908 S(ph)YTLVVAK ddPTM_A459_Selumetinib_30min_R1 2 SYTLVVAK 8 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 S(0.999)YT(0.001)LVVAK;S(0.962)YT(0.038)LVVAK 168.83 0.0002087 108893000.0 12054.5 8031.1 9307.5 9171.9 9183.3 6675.1 8569.7 10768.1 4073.3 8735.1 True False 12335.346396026132 7090.8150784429 8043.592622437875 7570.19984288629 8352.672136443298 6607.954554505874 7923.280629494951 10482.495008281707 6912.092597938774 9856.335172079289 1.2515145011473745 0.719416999792127 0.8160835119754761 0.7680542220531329 0.8474419741837189 0.670427135353988 0.8038769472795292 1.0635286671232715 0.7012842478732997 1.0 13.266835601457359 -10.726245275267773 18.008350700274868 0.9999993617080158 0.8415798326869419 0.06477474372038305 0.16991748651540273 0.0 0.0 0.15728914894674864 0.03814822205123256 1.878255740012107e-11 10.726245275267773 -0.15841952902107392 S(ph)YTLVVAK ddPTM_A459_Selumetinib_30min_R2 4 SYTLVVAK 8 0 E9PK52;E9PHY5;O43491-4;E9PII3;O43491-2;O43491-3;A0A2R8Y5B3;E9PJP4;E9PQN0;E9PRG1;E9PIG0;E9PQD2;O43491 E9PK52;O43491 EPB41L2 Band 4.1-like protein 2 1 S(0.992)YT(0.008)LVVAK;S(0.979)YT(0.021)LVVAK;S(0.995)YT(0.005)LVVAK;S(1)YTLVVAK 166.07 0.00025869 79772000.0 384268.0 276011.0 373743.0 382091.0 303877.0 284230.0 232044.0 253439.0 232763.0 354181.0 True False 362911.92290668376 297180.1561847545 349696.78228061023 330049.54665626027 265701.25456515164 323380.10251695197 242834.50578646315 254176.4655309152 279322.103941613 343954.8742572473 1.0551149295103703 0.8640091431368712 1.01669378297302 0.9595722327499651 0.7724887025919307 0.9401817701094497 0.706006874625201 0.738982013497544 0.8120893897631035 1.0 18.391859774958 -6.24647710286312 20.228567665300087 0.8147208879136194 0.9690626451499523 0.35499227608557515 0.09498126587969022 69.3113957907996 93704.75378288704 0.02725959397510202 0.03492397941515205 5.669214603120896e-07 6.24647710286312 0.15434175723633292 S(ph)YVSEPELATLSGDMAQPSLGLVGPESR ddPTM_A459_Selumetinib_30min_R2 1 SYVSEPELATLSGDMAQPSLGLVGPESR 28 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 S(0.543)YVS(0.457)EPELATLSGDMAQPSLGLVGPESR 104.52 9.0803e-10 1823300.0 10181.0 9616.0 9819.0 10844.0 9848.7 8781.9 8733.2 9740.0 9660.6 9374.9 True False 9615.18077777214 10353.516279686672 9187.256230118863 9367.028493056601 8611.418257504887 9991.527010849044 9139.311104507502 9768.341787456202 11592.989939716968 9104.222278084544 1.0561232452460616 1.1372213862362957 1.0091203783802813 1.0288664102154752 0.9458708272351914 1.097460794086761 1.0038541267283667 1.0729463197499374 1.2733641145409338 1.0 13.152320065897923 -8.014957503756746 24.572688899960216 1.1488397904970007 1.0403889830061566 0.18897423810512426 0.07868915825587315 750.8473519084032 1233509.447058282 0.04724640237118386 0.01920937911524005 9.661454128683107e-09 8.014957503756746 -0.10845080749084413 S(ph)YVTTSTR ddPTM_A459_Selumetinib_30min_R1 3 SYVTTSTR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(0.807)YVT(0.183)T(0.01)STR;S(0.998)YVT(0.001)TSTR;S(0.991)YVT(0.007)T(0.002)STR 122.96 0.0061456 241355000.0 5306.969999999999 6487.070000000001 5162.52 5727.2300000000005 5824.62 5450.54 5354.94 4968.65 3380.67 4593.4400000000005 True False 5430.612075433966 5727.560828642976 4461.478139692509 4727.07679392205 5297.784149420182 5395.712516294357 4951.012564513072 4836.865261550217 5736.750075632455 5183.052767894572 1.0477632234564258 1.1050554731221829 0.860781925148106 0.91202559680716 1.022135869855752 1.0410298250708665 0.9552309780022251 0.9332077982132948 1.1068284141669664 1.0 12.339586366324559 S(ph)YVTTSTR ddPTM_A459_Selumetinib_30min_R2 2 SYVTTSTR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(0.998)YVT(0.001)T(0.001)STR;S(1)YVTTSTR 122.96 0.0061456 174503000.0 62973.0 52695.0 68061.0 60872.0 54198.0 47127.0 57865.0 31612.0 55185.0 77832.0 True False 59473.21276089241 56736.537058869464 63682.029359213804 52581.12858994298 47389.16270373247 53618.31647368827 60555.837157322254 31703.985686351672 66223.54199773105 75584.78792817824 0.7868410349633411 0.7506343354800618 0.8425244166819043 0.6956575526798637 0.6269669334623568 0.7093797302790235 0.8011643455937627 0.41944929072867493 0.8761490746082085 1.0 16.2058082887461 -8.517447277687504 24.985554507984325 1.0000000327262366 0.7068680779387695 0.43290060152075116 0.11168317863193675 337.4450116773497 1552294.1997402369 0.10663950129826248 0.027534200796062124 3.0377548457432724e-09 8.517447277687504 -0.2931319547874671 SAAAGALGS(ph)PGLPLRK ddPTM_A459_Selumetinib_30min_R1 1 SAAAGALGSPGLPLRK 16 1 O75145-2;O75145;A0A0C4DGR8;A0A0C4DGR7 O75145-2 PPFIA3 Liprin-alpha-3 1 SAAAGALGS(1)PGLPLRK 105.63 0.013685 0.0 1016.5 736.14 818.24 1036.9 850.8 691.78 847.11 786.57 610.72 733.75 True False 1040.1824722353108 649.9523865777985 707.1275022705958 855.8248800236373 773.8452902209405 684.8213212859847 783.2118106878261 765.7076084605587 1036.3472347760217 827.9339598302449 1.256359229966342 0.7850292633376957 0.8540868433704317 1.0336873730836105 0.9346703091869857 0.8271448624071378 0.9459834342927684 0.924841407178847 1.2517269312017454 1.0 9.693371885488283 -8.236221479308226 24.15067010371059 1.1258634742835587 0.9355336532407319 0.21715311620942201 0.1361998504795757 590.6670989041793 565672.0760434247 0.0875117462599507 0.03304277247258038 5.804683177226344e-09 8.236221479308226 -0.1903298210428268 SAADSISES(ph)VPVGPK ddPTM_A459_Selumetinib_30min_R1 1 SAADSISESVPVGPK 15 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 SAADS(0.286)IS(0.105)ES(0.609)VPVGPK 136.51 0.00040538 12982000.0 2336.5 3594.9 3127.3 3683.6 2654.3 3155.3 3424.4 2455.6 1883.2 2369.2 True False 2390.935903962424 3174.0074367763327 2702.6298370292743 3040.3284097358187 2414.219033654728 3123.5605467831797 3166.0947509997445 2390.469511087058 3195.6528565139556 2673.309897962272 0.8943728917417741 1.187294985589107 1.010967654400768 1.1372899236460787 0.9030823682263565 1.1684244124349785 1.1843351021193231 0.8941984290370493 1.1953918469945588 1.0 11.384411373398505 SAAEMYGSVTEHPS(ph)PSPLLSSSFDLDYDFQR ddPTM_A459_Selumetinib_30min_R1 1 SAAEMYGSVTEHPSPSPLLSSSFDLDYDFQR 31 0 G3V2Q1;P07910;G3V576;G3V555;G3V575 G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 SAAEMYGSVTEHPS(0.988)PS(0.012)PLLSSSFDLDYDFQR 144.44 2.0569000000000003e-19 10557000.0 671.74 519.09 678.1 683.05 761.42 679.69 659.7 554.67 208.18 528.58 True False 687.390235021493 458.31470148160633 586.0177445366771 563.7681399364888 692.5496954396195 672.8529357091426 609.9382978724827 539.9583497779194 353.26625513438626 596.428391805208 1.152510920784591 0.7684320662442421 0.9825450172869521 0.9452402797763089 1.1611615157076636 1.1281369984293013 1.0226513463357845 0.9053196614997302 0.5923028816001806 1.0 9.22020512570197 -7.9915263583507725 5.422038907635541 0.7799061213748902 1.0155808094099634 0.28911586213390983 0.14273662799300352 0.1944672446877767 18.57040333956888 0.08683634541525967 0.03736909415939261 1.0197028700076504e-08 7.9915263583507725 0.2356746880350732 SAAPS(ph)SPGSPR ddPTM_A459_Selumetinib_30min_R1 2 SAAPSSPGSPR 11 0 Q9H211;H3BSY1 Q9H211 CDT1 DNA replication factor Cdt1 1 SAAPS(0.5)S(0.5)PGSPR;SAAPS(0.492)S(0.492)PGS(0.016)PR 112.64 0.0075536 2918700.0 3334.2 4462.5 3513.9 3374.3 3305.2 3435.3 3474.9 3324.8 2311.6 2785.1000000000004 True False 3411.880372776168 3940.0284254400326 3036.7316804710686 2785.0418484557404 3006.245243580456 3400.744001002835 3212.785495341959 3236.6155035275524 3922.61636741592 3142.5947141713355 1.0856889554960765 1.2537500962732226 0.966313494634582 0.8862236787635286 0.9566124546776522 1.082145268579302 1.0223352953704474 1.0299182038753631 1.2482094333472673 1.0 11.617740511123662 -10.180147656602337 13.713152067106837 0.9999999977175498 1.0526732098596008 0.021454333875195686 0.1124518854913487 0.0 0.0 0.11524102294789727 0.027950053530494665 6.604688557744898e-11 10.180147656602337 0.05267321214205101 SAAPS(ph)SPGSPR ddPTM_A459_Selumetinib_30min_R2 2 SAAPSSPGSPR 11 0 Q9H211;H3BSY1 Q9H211 CDT1 DNA replication factor Cdt1 1 SAAPS(0.369)S(0.369)PGS(0.261)PR;SAAPS(0.5)S(0.5)PGSPR 116.74 0.0058015 6910000.0 17095.1 16440.0 17254.199999999997 22299.0 23904.0 22375.0 21041.6 22479.0 21787.3 22336.0 True False 16145.022779107418 17700.8951370683 16144.08355695254 19261.837732079413 20900.96581552863 25456.953149972935 22020.076093139414 22544.41016840123 26145.368788025105 21691.10164410251 0.7443154821736319 0.8160440823843962 0.7442721822910215 0.8880064299231396 0.9635732734308262 1.1736127361191129 1.015166332002614 1.0393391049610763 1.2053499733211404 1.0 14.404815705778786 -6.2452346511911765 1.8401677714252092 1.084207433485743 0.7733897021901962 0.803061627533912 0.06813563130166207 0.14406248483317738 0.9606444618110337 0.02296450849604743 0.030655414473317325 5.685456601567281e-07 6.2452346511911765 -0.3108177312955468 SAAPSSPGS(ph)PRPALPATPPATPPAASPSALK ddPTM_A459_Selumetinib_30min_R1 2 SAAPSSPGSPRPALPATPPATPPAASPSALK 31 1 Q9H211;H3BSY1 Q9H211 CDT1 DNA replication factor Cdt1 1 SAAPS(0.021)S(0.066)PGS(0.902)PRPALPAT(0.011)PPATPPAASPSALK;SAAPS(0.006)S(0.013)PGS(0.648)PRPALPAT(0.332)PPAT(0.002)PPAASPSALK 88.346 5.0819e-07 27929000.0 2901.6000000000004 3434.1000000000004 4114.9 3691.0 3713.6000000000004 3260.4 3116.3999999999996 3216.0 1834.9299999999998 2696.6000000000004 True False 2969.201634469238 3032.0339755302234 3556.119181527759 3046.436138651023 3377.705535689332 3227.6033362063426 2881.3274389719645 3130.701232959757 3113.742192015271 3042.7348771083352 0.9758331745587444 0.9964831304696906 1.1687246260861606 1.0012164259103 1.1100886774924459 1.060757333965849 0.9469531705339492 1.0289102926821612 1.023336674989711 1.0 11.571152917514143 -7.201671458380934 24.99800474651141 1.0022089636238805 1.0552647146491911 0.16546161188295516 0.057282002140570346 466.5629198308065 195140.42476305444 0.022066812058157005 0.017092869252887527 6.28533661602562e-08 7.201671458380934 0.05305575102531068 SAAPSSPGS(ph)PRPALPATPPATPPAASPSALK ddPTM_A459_Selumetinib_30min_R2 2 SAAPSSPGSPRPALPATPPATPPAASPSALK 31 1 Q9H211;H3BSY1 Q9H211 CDT1 DNA replication factor Cdt1 1 SAAPS(0.029)S(0.096)PGS(0.84)PRPALPAT(0.033)PPATPPAASPSALK;S(0.001)AAPS(0.019)S(0.017)PGS(0.814)PRPALPAT(0.148)PPAT(0.001)PPAASPSALK 83.46700000000001 2.2855e-06 11062300.0 47261.0 42187.0 46978.0 55224.0 54638.0 40540.0 41861.0 48423.0 34378.0 50808.0 True False 44634.42282077294 45422.60724741486 43955.486625779035 47702.39593328638 47773.885970082534 46124.01701452081 43807.61944599788 48563.902913140795 41254.560601576486 49341.04102496241 0.9046104803137753 0.9205846959012245 0.8908504099769857 0.9667894098374006 0.9682383058337373 0.9348002404567415 0.8878535704959065 0.9842496612216096 0.836110461891251 1.0 15.59050053429788 -5.746080673700965 24.99917239952539 0.9378861185606924 0.906872148566828 0.10411633466594605 0.04591871002028177 618.8206053365417 1007238.0309328076 0.01188411416765803 0.020489906498037423 1.7944002715562384e-06 5.746080673700965 -0.03101396999386441 SAAQAAAQT(ph)NSNAAGK ddPTM_A459_Selumetinib_30min_R1 3 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 SAAQAAAQT(0.98)NS(0.02)NAAGK;S(0.003)AAQAAAQT(0.944)NS(0.053)NAAGK;SAAQAAAQT(0.574)NS(0.426)NAAGK 190.37 2.3575e-06 5179400.0 1607.96 3177.0699999999997 2950.46 3417.09 2780.42 2552.32 2927.55 2698.13 1195.96 2128.02 True False 1645.4223394544913 2805.0971674202283 2549.8037377166875 2820.3593782235207 2528.9315019230226 2526.6459781211415 2706.7225465159745 2626.5668276385913 2029.456770537614 2401.1720956701315 0.6852579798097639 1.1682199591101643 1.061899620737128 1.1745761094380869 1.0532071010167372 1.0522552642841672 1.1272505420985115 1.0938686287313177 0.845194217522848 1.0 11.22952309209226 -4.752566765555742 24.99996571570631 1.0716397386487122 0.6852572413599182 0.6143733909581179 0.08985020041644874 222.7883835576007 627694.6103967975 0.021734214217399943 0.25557065176160737 1.767800426920107e-05 4.752566765555742 -0.38638249728879404 SAAQAAAQT(ph)NSNAAGK ddPTM_A459_Selumetinib_30min_R2 2 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 SAAQAAAQT(0.999)NS(0.001)NAAGK;SAAQAAAQT(1)NSNAAGK 214.94 1.9379e-08 3374500.0 18061.0 17195.4 16354.8 15713.900000000001 17322.8 12189.0 10683.7 11018.7 9467.0 15794.5 True False 17057.241923911468 18514.231888074468 15302.549973759864 13573.639712010525 15146.554996203104 13867.924109274649 11180.513219349934 11050.76259275602 11360.664530081001 15338.471745960642 1.1120561556860096 1.2070454080896396 0.9976580605424241 0.8849408165833156 0.9874878832170435 0.904126847769351 0.7289196345323191 0.7204604719284513 0.7406646971249148 1.0 13.904867126121822 -5.76614796786748 0.6917885819314792 0.7879040622182036 1.214987521273096 0.617899808431569 0.09686139982228752 0.7066380479893946 0.5755080364012928 0.053246176844507775 0.19748615611738068 1.7133734469724133e-06 5.76614796786748 0.4270834590548924 SAAQAAAQTNS(ph)NAAGK ddPTM_A459_Selumetinib_30min_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 SAAQAAAQT(0.004)NS(0.996)NAAGK 128.44 0.00095387 2513600.0 1149.6 1685.2 1539.3 1643.6 1369.0 1361.9 1422.4 1398.6 634.74 1117.2 True False 1176.3834432677954 1487.8960005717743 1330.2715147696613 1356.5761141931237 1245.1741917165814 1348.2005225062626 1315.10722281919 1361.5045847069389 1077.1074204246338 1260.6035024495395 0.9331906828609535 1.1803045110382224 1.0552656026932707 1.0761322743884933 0.9877603777056174 1.0694881617308767 1.0432362120712355 1.0800418863356587 0.8544379087727857 1.0 10.299898860883456 -8.247514999998966 24.94201267844123 0.9272189488520682 1.0562815455500885 0.34938906355988186 0.06864882195224975 667.9077947963926 1196393.675722087 0.04370644137682082 0.01633677733232081 5.655682227187752e-09 8.247514999998966 0.12906259669802023 SAAQAAAQTNS(ph)NAAGK ddPTM_A459_Selumetinib_30min_R2 4 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 SAAQAAAQT(0.28)NS(0.72)NAAGK;SAAQAAAQTNS(1)NAAGK;SAAQAAAQT(0.019)NS(0.981)NAAGK;SAAQAAAQTNS(1)NAAGK 230.06 2.9668000000000008e-15 8661200.0 32773.2 30495.7 33781.0 31996.2 34475.9 19019.699999999997 23876.1 31359.0 22356.399999999998 26908.699999999997 True False 30951.79674551438 32834.62213086944 31607.56723797182 27638.26236347634 30144.729223543494 21639.491031353755 24986.38595959462 31450.249498238092 26828.304690007702 26131.77591380107 1.184450564998443 1.2565017486442003 1.2095453191636625 1.0576496008018974 1.153566038641218 0.828091098849704 0.9561686906399067 1.2035251489214003 1.026654475321701 1.0 14.67351755300079 -5.899667466593135 1.7014603618449033 1.02188009467099 1.228707552118774 0.4305401937650558 0.09765708254189544 0.37346498347511065 2.200181513694678 0.03382547940946399 0.0620990344139229 1.2598897230760766e-06 5.899667466593135 0.20682745744778397 SAAS(ph)REDLVGPEVGASPQSGR ddPTM_A459_Selumetinib_30min_R1 2 SAASREDLVGPEVGASPQSGR 21 1 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 SAAS(1)REDLVGPEVGASPQSGR;S(0.015)AAS(0.985)REDLVGPEVGASPQSGR 195.36 8.6937e-16 18891100.0 2419.7200000000003 3113.3 3054.8999999999996 3083.2 3065.7 2698.8999999999996 3002.2 2766.04 1685.27 2479.0299999999997 True False 2476.094768044493 2748.7933886660953 2640.0613593645426 2544.7769988319765 2788.4079762932956 2671.7515164051347 2775.7416369149128 2692.675633835823 2859.78010274919 2797.2376482970653 0.88519285072254 0.9826813929590635 0.9438101767905882 0.9097464423093315 0.9968434315871785 0.9551392667804519 0.9923152716769563 0.9626195455631384 1.0223586488942762 1.0 11.449787112468007 -1.5228787452816877 0.17107175870417238 1.014670558089633 0.6104862092328772 0.46649213902345854 0.029725131896359502 56.843718778692846 0.61803393146431 0.07397423676045065 5.88859022016846 0.02999999999990674 1.5228787452816877 -0.4041843488567557 SAAS(ph)REDLVGPEVGASPQSGR ddPTM_A459_Selumetinib_30min_R2 3 SAASREDLVGPEVGASPQSGR 21 1 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 S(0.064)AAS(0.936)REDLVGPEVGASPQSGR;SAAS(1)REDLVGPEVGASPQSGR;S(0.021)AAS(0.979)REDLVGPEVGASPQSGR 181.49 1.0058e-13 9215900.0 22902.9 30132.6 27889.4 30581.5 34748.9 30183.5 27821.6 24893.9 26191.6 36482.8 True False 21630.04850557289 32443.673528419953 26095.026367682764 26416.246943969967 30383.432522892504 34341.00314646742 29115.35952745453 24966.33712759301 31430.651854449105 35429.44677030185 0.6105104786367683 0.915726224537475 0.7365349658678975 0.7456014516747393 0.8575756974100119 0.9692785599817267 0.8217841987829174 0.7046775889405259 0.8871335772816901 1.0 15.112661317543823 -14.522878745280336 0.06221352980121169 1.6061207753424565 0.555985026821694 0.31866628281029274 0.097392954869198 550.7956502179115 2.4862090122105074 51.55908029409907 8.017153969488975 3.0000000000000132e-15 14.522878745280336 -1.0501357485207623 SAASQTADGS(ph)GCRVSYER ddPTM_A459_Selumetinib_30min_R2 1 SAASQTADGSGCRVSYER 18 1 Q13905-2;Q13905;Q13905-4;Q13905-3 Q13905-2 RAPGEF1 Rap guanine nucleotide exchange factor 1 1 SAASQT(0.001)ADGS(0.609)GCRVS(0.385)Y(0.004)ER 55.734 0.036555 2877100.0 7937.8 9355.2 7795.0 9050.7 11128.0 8103.2 5471.2 8294.1 10661.0 9616.7 True False 7496.648853531063 10072.713758290836 7293.47818655429 7817.979046671652 9730.001154417776 9219.342246474225 5725.621640977126 8318.234457837834 12793.497893228427 9339.040883812699 0.8027214942944471 1.0785597668546252 0.7809665122246151 0.8371286884740494 1.0418630002233662 0.9871829839029888 0.6130845460695338 0.8906947256495876 1.3698941949599253 1.0 13.189058677935568 -8.21072699457436 13.04624196932047 1.1848695104945401 0.8811410212277707 0.38962148710844935 0.1531431208452143 1.7853807695436028 458.8226717397891 0.10189656403550464 0.03847423006667879 6.15563705675046e-09 8.21072699457436 -0.30372848926676943 SAAVETASLS(ph)PSLVPAR ddPTM_A459_Selumetinib_30min_R1 3 SAAVETASLSPSLVPAR 17 0 Q2KHT3;Q2KHT3-3 Q2KHT3 CLEC16A Protein CLEC16A 1 SAAVETAS(0.009)LS(0.595)PS(0.396)LVPAR;S(0.049)AAVET(0.019)AS(0.198)LS(0.677)PS(0.058)LVPAR;SAAVETAS(0.001)LS(0.936)PS(0.063)LVPAR 247.5 2.2318999999999997e-30 32136200.0 3890.7699999999995 4646.07 4607.3 5692.599999999999 5252.4 3922.1200000000003 4727.8 4968.2 2698.41 4171.4 True False 3981.4173708794706 4102.105964500656 3981.653966087356 4698.49427333644 4777.321347386539 3882.6670338000304 4371.178239626384 4836.427197012023 4579.004685931301 4706.839822876843 0.8458790867554973 0.8715201958993858 0.8459293530098821 0.9982269314753731 1.0149742772565007 0.8248989088026637 0.9286864231880105 1.027531715335912 0.9728405593230048 1.0 12.200543042581282 -1.5228787454518118 0.22810160310779912 0.9994306757690258 0.08425846962859902 0.37697165161499724 0.05940523441922598 59.66966213220934 0.7777162709582286 0.09482495872345716 20.333550176153338 0.02999999998815498 1.5228787454518118 -0.9151722061404267 SAAVETASLS(ph)PSLVPAR ddPTM_A459_Selumetinib_30min_R2 2 SAAVETASLSPSLVPAR 17 0 Q2KHT3;Q2KHT3-3 Q2KHT3 CLEC16A Protein CLEC16A 1 S(0.05)AAVETAS(0.005)LS(0.933)PS(0.012)LVPAR;SAAVETAS(0.002)LS(0.573)PS(0.425)LVPAR 191.36 7.776099999999999e-08 27185000.0 64284.0 48266.0 64219.0 56643.0 58364.0 44765.0 46935.0 43289.0 41124.0 53352.0 True False 60711.352629241206 51967.84700034905 60087.219456360464 48928.125685374864 51031.792539219874 50930.97241378941 49117.570499938105 43414.96382312027 49349.94910056522 51811.58913485657 1.1717716758546064 1.0030158863702436 1.159725467982923 0.9443471335732136 0.9849493789197042 0.9830034798049705 0.9480035513308345 0.83793924386528 0.9524886212641708 1.0 15.660987213317279 -5.823809007597009 0.7700788661881549 0.9260900475194304 1.135963144129804 0.521316982241361 0.06557896607479101 0.7080380628918023 0.7634915821520594 0.03141204823668548 0.10104881574225762 1.5003445063336663e-06 5.823809007597009 0.20987309661037357 SAAVETASLSPS(ph)LVPAR ddPTM_A459_Selumetinib_30min_R1 1 SAAVETASLSPSLVPAR 17 0 Q2KHT3;Q2KHT3-3 Q2KHT3 CLEC16A Protein CLEC16A 1 SAAVET(0.003)AS(0.007)LS(0.387)PS(0.603)LVPAR 172.42 5.567899999999999e-07 6805200.0 1366.3 1908.9 1811.6 1882.2 1826.2 1636.6 1532.6 1783.3 931.54 1313.4 True False 1398.1321316429967 1685.4051005764668 1565.5946704064966 1553.5091032698326 1661.0205324417961 1620.137289913906 1416.9947480966603 1736.00109102523 1580.755343010307 1481.9876835993794 0.9434168361286793 1.1372598566291976 1.0564154397046381 1.0482604683304422 1.1208058952336166 1.093219132549736 0.9561447532783354 1.171400484792772 1.0666453982741917 1.0 10.53331774250561 -4.743521390998297 24.995492050458296 1.0748968853006375 0.9434164258214464 0.28963130012950566 0.060395525562155945 1453.1062191748206 2026968.8135909855 0.014339948829132936 0.45029251270326726 1.8050058301130723e-05 4.743521390998297 -0.13148045947919118 SADAGS(ph)FSPTPGQIGGAVK ddPTM_A459_Selumetinib_30min_R1 1 SADAGSFSPTPGQIGGAVK 19 0 O00443 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 SADAGS(0.494)FS(0.494)PT(0.013)PGQIGGAVK 282.67 7.878499999999998e-72 9895800.0 1802.4 2683.3 2180.4 2512.8 1942.5 1740.3 1568.1 2046.8 969.2 1593.3 True False 1844.3924131401143 2369.1379885676724 1884.3136560798885 2073.9866510978823 1766.8012179762297 1722.794162065974 1449.8169545154467 1992.5122150566021 1644.6616124327352 1797.8155750562598 1.0259074616607418 1.3177869974196512 1.048112877774419 1.1536147977987008 0.9827488661738513 0.9582707959419374 0.8064325254663994 1.1082962249863975 0.9148110825445864 1.0 10.812029317417489 -6.316072958478116 3.7314471285057067 0.9559699223052498 1.1445100664720929 0.4151512830095869 0.10147920156295365 0.22299387703039017 6.358138322646695 0.03124014489289971 0.036851846536454375 4.829776583081317e-07 6.316072958478116 0.18854014416684306 SADAGS(ph)FSPTPGQIGGAVK ddPTM_A459_Selumetinib_30min_R2 1 SADAGSFSPTPGQIGGAVK 19 0 O00443 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 SADAGS(0.5)FS(0.5)PT(0.001)PGQIGGAVK 258.8 3.2509e-47 5314800.0 49772.0 45649.0 47740.0 55413.0 57198.0 34784.0 44017.0 46399.0 40875.0 40280.0 True False 47005.871493102364 49150.13151533035 44668.460375381874 47865.65380724321 50012.275883392125 39575.180262286405 46063.8777180308 46534.01340823204 49051.14214292395 39117.011739991445 1.2016733743760317 1.2564899344057385 1.1419190369727266 1.2236531288587045 1.278530073202444 1.011712768995249 1.177591939389818 1.1896106409544005 1.2539593379209053 1.0 15.25550854246328 -6.708844738127425 24.99999658083666 1.1416106942161763 1.2182698135329646 0.24490051955947634 0.08023345318916275 175.9042685299413 83612.37566790922 0.026320001023430045 0.026319970151431397 1.9550382642155618e-07 6.708844738127425 0.07665911931678826 SADAGSFS(ph)PTPGQIGGAVK ddPTM_A459_Selumetinib_30min_R1 1 SADAGSFSPTPGQIGGAVK 19 0 O00443 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 SADAGS(0.001)FS(0.5)PT(0.5)PGQIGGAVK 113.28 0.00053742 5512800.0 1609.0 2410.9 2400.7 2332.5 1975.6 2190.5 2000.6 2022.7 895.98 1789.2 True False 1646.486569431004 2128.6307072029967 2074.698126101166 1925.1726614477127 1796.9073288205082 2168.4655588148685 1849.6931313076996 1969.0514253444358 1520.412620209949 2018.861248283849 0.8155521192110724 1.0543719678667656 1.0276576103804964 0.9535933502533782 0.8900598445524601 1.0741033147563717 0.9162061696315424 0.9753277631230207 0.7531040686933732 1.0 10.979326045608104 SADAGSFS(ph)PTPGQIGGAVK ddPTM_A459_Selumetinib_30min_R2 3 SADAGSFSPTPGQIGGAVK 19 0 O00443 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 SADAGS(0.255)FS(0.561)PT(0.183)PGQIGGAVK;SADAGSFS(0.999)PT(0.001)PGQIGGAVK;SADAGS(0.01)FS(0.912)PT(0.078)PGQIGGAVK 251.74 8.266599999999998e-38 17147000.0 101925.0 101504.0 115933.0 116122.0 128639.0 89789.0 89962.0 110179.0 84368.0 101536.0 True False 96260.41653810303 109289.03041319855 108473.99699830633 100305.9832783766 112478.21877274867 102156.61972661095 94145.41125632125 110499.60264888477 101243.95743887968 98604.39185778993 0.9762284896694313 1.108358647663669 1.1000929568608935 1.017256750825468 1.1407019165532502 1.0360250471798877 0.9547790872449217 1.1206357096979052 1.0267692496384604 1.0 16.589364285486774 -6.969603938247905 24.999425554516638 1.0298564844360008 1.071517583101706 0.10941381734241185 0.05810590439496822 475.8723894168014 391382.9815660841 0.02004148627844267 0.0176748079172693 1.0724969400074946e-07 6.969603938247905 0.04166109866570533 SADCSVPS(ph)PALDK ddPTM_A459_Selumetinib_30min_R2 1 SADCSVPSPALDK 13 0 Q68DC6;O43439-2;O43439-5;O43439;O43439-4 Q68DC6 DKFZp313F2116;CBFA2T2 Protein CBFA2T2 1 SADCS(0.001)VPS(0.999)PALDK 112.96 0.0054086 0.0 29905.0 24857.0 30872.0 33751.0 26310.0 21104.0 29923.0 27818.0 17543.0 28361.0 True False 28242.999819200064 26763.451972147624 28885.729130892127 29154.055576277522 23004.70258561572 24010.88443696217 31314.478791299636 27898.945774482174 21052.09019237466 27542.144239272504 1.0254466599927323 0.9717272460575332 1.0487828718035612 1.058525266696795 0.8352545969464926 0.8717870412836234 1.1369658992144895 1.0129547478987095 0.7643591584404079 1.0 14.749353261569286 -6.202698671260428 24.99978638740757 0.9442827264473734 1.023854028555137 0.15931044533372152 0.09950157848336379 602.0837755201043 256243.4446400495 0.030791571453448796 0.03975173775223837 6.270487822061957e-07 6.202698671260428 0.07957130210776353 SADGS(ph)APAGEGEGVTLQR ddPTM_A459_Selumetinib_30min_R2 4 SADGSAPAGEGEGVTLQR 18 0 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 SADGS(1)APAGEGEGVTLQR;S(0.139)ADGS(0.861)APAGEGEGVTLQR;SADGS(1)APAGEGEGVTLQR;SADGS(1)APAGEGEGVTLQR 245.18 9.0906e-26 26057200.0 84011.0 27650.7 61572.0 74759.0 46578.0 40529.7 116969.0 69678.0 52831.2 48013.9 True False 79342.00494267906 29771.419778986285 57610.52455452481 64576.6952335318 40726.45522739678 46112.298283014876 122408.29026967629 69880.75144418614 63398.91622706405 46627.61395190603 1.7016098019623358 0.6384933144915792 1.2355451989018156 1.384945309449875 0.8734406883741469 0.9889482728105565 2.6252317005955765 1.4986988507768062 1.3596860498256838 1.0 15.50889698491185 SADGSAPAGEGEGVT(ph)LQR ddPTM_A459_Selumetinib_30min_R2 2 SADGSAPAGEGEGVTLQR 18 0 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 SADGSAPAGEGEGVT(1)LQR;SADGSAPAGEGEGVT(1)LQR 141.3 0.00018565 2593900.0 33793.0 23882.3 37519.0 38697.0 38092.0 27775.0 44054.0 33283.0 33563.0 31947.0 True False 31914.92034409724 25713.9956163021 35105.068387598505 33426.4018439516 33306.54241319932 31600.75413365357 46102.59829134491 33379.84801970274 40276.53782857385 31024.607101725585 1.028697002977425 0.8288258262865121 1.1315233831162994 1.0774157988319029 1.0735524322352117 1.0185706471652929 1.4860010358932374 1.0759152536647645 1.2982126637901459 1.0 14.921125319607539 SADTLWDIQK ddPTM_A459_Selumetinib_30min_R2 2 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 ; 175.73 0.00081565 23375000.0 125049.0 116305.0 129152.0 134635.0 137749.0 97786.0 103373.0 109604.0 108360.0 124019.0 False True 118099.2771908092 125225.21952048223 120842.50093006513 116297.48074167082 120443.7391283155 111255.13388707276 108180.04932971357 109922.92949408093 130035.02783136946 120438.24922994063 0.9805794915312505 1.0397462626794112 1.003356505949806 0.9656191574126567 1.0000455826816645 0.9237525005421204 0.89822004239846 0.9126911940094392 1.0796821496724571 1.0 16.87793411579503 -5.946897137032826 1.5695646043872713 0.9574074947989465 1.012456885308502 0.08434532493418379 0.05192132960625845 0.768713685930798 3.8423414197181267 0.01795001928792793 0.032475257819201055 1.1300635393577037e-06 5.946897137032826 0.055049390509555596 SADTLWGIQK ddPTM_A459_Selumetinib_30min_R2 2 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 ; 160.59 0.006089100000000001 20316000.0 129867.0 115515.0 123007.0 140064.0 137186.0 104884.0 107915.0 118420.0 95646.0 114302.0 False True 122649.51203879142 124374.62906073252 115092.86353989544 120987.04157612288 119951.4682215992 119330.81895784405 112933.26132951581 118764.58259451379 114777.87257252824 111001.80426773838 1.1049325985995557 1.120473940772518 1.036855790760746 1.0899556306697495 1.0806262926346142 1.0750349487114277 1.0174002312351493 1.0699338031303658 1.0340180804240076 1.0 16.760223601345196 -1.5228787453184416 0.0761796939232523 0.9349706073993909 1.3903168301977331 0.6107302111701538 0.023230721282721283 147.3619093784903 0.8257192079346868 0.7881025513058345 7.105300790363511 0.029999999997367868 1.5228787453184416 0.45534622279834225 SADVS(ph)PTTEGVK ddPTM_A459_Selumetinib_30min_R2 1 SADVSPTTEGVK 12 0 A0A0J9YX34;Q9C040;Q9C040-2 A0A0J9YX34 TRIM2 Tripartite motif-containing protein 2 1 SADVS(0.427)PT(0.427)T(0.146)EGVK 137.81 0.0012934 3643600.0 31846.0 24725.0 32726.0 32792.0 31718.0 23199.0 26525.0 26561.0 24538.0 30233.0 True False 30076.126809638718 26621.327996594508 30620.444789374706 28325.67303064479 27733.301277482315 26394.451670445684 27758.46505829037 26638.288112589726 29446.285649004723 29360.094735232415 1.0243879347414726 0.9067180551242786 1.042927315647584 0.9647677667965319 0.9445916822673623 0.8989906847532093 0.9454487565048599 0.9072957138869006 1.0029356483536438 1.0 14.84156900283376 -4.731701023130328 24.4613599815247 0.9545327798716658 1.02438848102508 0.16657294266761613 0.044846754688667105 5106.526696673597 4200084.121436501 0.011098147433206515 1.2575807914793635 1.8548080703831065e-05 4.731701023130328 0.06985570115341422 SADVSPTT(ph)EGVK ddPTM_A459_Selumetinib_30min_R2 1 SADVSPTTEGVK 12 0 A0A0J9YX34;Q9C040;Q9C040-2 A0A0J9YX34 TRIM2 Tripartite motif-containing protein 2 1 SADVS(0.079)PT(0.265)T(0.655)EGVK 129.76 0.0048288 0.0 37940.0 32397.0 31913.0 39193.0 32979.0 26659.0 27790.0 31428.0 23419.0 32016.0 True False 35831.44668585357 34881.745727226364 29859.752324247234 33854.8457883039 28835.88318399926 30331.035263692913 29082.29006484033 31519.45027681453 28103.45438153237 31091.614892442045 1.1524472694586125 1.1219020256070922 0.9603795887586959 1.088873829983452 0.9274488727508611 0.9755374678549097 0.9353740603518746 1.0137604748371074 0.9038917559847927 1.0 14.924237931474874 -4.64274175455185 0.7006796197435807 0.9609245593218995 1.327918747286961 0.6190117980857179 0.05029654172259681 2.2282288945394315 0.7252155126644794 0.020141533944433607 0.6793205378995165 2.2764506790813956e-05 4.64274175455185 0.36699418796506145 SAEALGPGALVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SAEALGPGALVSPR 14 0 Q9P227;Q9P227-2 Q9P227 ARHGAP23 Rho GTPase-activating protein 23 1 SAEALGPGALVS(1)PR 149.59 0.00017759 0.0 47631.0 36900.0 43575.0 52980.0 53019.0 41074.0 38820.0 35429.0 33960.0 42212.0 True False 44983.85970200027 39730.1113477993 40771.43194087278 45764.03260440233 46358.279224126185 46731.570667351414 40625.20692037067 35532.092524413325 40752.94892168064 40993.229880052575 1.0973485093422597 0.9691871429514288 0.9945894007418108 1.1163802593332917 1.1308764730120535 1.1399826460147053 0.9910223478179506 0.8667795298975294 0.99413852094419 1.0 15.323098044768743 -7.513453478317805 24.120300155518727 0.9440555907164708 1.0702971590274981 0.44017443612455454 0.06240666189500771 277.80932653113274 710953.3285976746 0.030075599866690797 0.01862064559625719 3.065819072780232e-08 7.513453478317805 0.12624156831102729 SAEPPRS(ph)PLLK ddPTM_A459_Selumetinib_30min_R2 1 SAEPPRSPLLK 11 1 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;H7C1I9;O15021-2;O15021-3;O15021-6;O15021;Q9Y2H9 Q6P0Q8;H7C1I9;Q9Y2H9 MAST2;MAST4;MAST1 Microtubule-associated serine/threonine-protein kinase 2;Microtubule-associated serine/threonine-protein kinase 4;Microtubule-associated serine/threonine-protein kinase 1 1 SAEPPRS(1)PLLK 89.992 0.015648 13904000.0 73044.0 68447.0 74858.0 80487.0 87711.0 68681.0 82787.0 84463.0 68375.0 66960.0 True False 68984.50689829965 73696.6648082064 70041.71777922797 69524.5317521806 76691.96003371113 78141.18432595718 86636.75953932833 84708.77334639768 82051.91055712337 65026.69081702642 1.0608644855142608 1.133329466442876 1.0771225922646586 1.0691691500619385 1.1793920168797873 1.2016786237182608 1.3323261333274488 1.302676982052695 1.2618189473612136 1.0 15.988744387006838 -6.562696859175187 2.2154292586276063 1.2482047738446214 1.0881368151321373 0.32258494259656556 0.08778444764936362 0.30514041541455 3.030287009608008 0.03077430056828335 0.0322791291299021 2.73717863099974e-07 6.562696859175187 -0.16006795871248403 SAEPRPELGPGQETGTNS(ph)R ddPTM_A459_Selumetinib_30min_R1 4 SAEPRPELGPGQETGTNSR 19 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 SAEPRPELGPGQET(0.033)GT(0.25)NS(0.717)R;SAEPRPELGPGQETGT(0.001)NS(0.998)R;SAEPRPELGPGQET(0.002)GT(0.013)NS(0.984)R;SAEPRPELGPGQET(0.039)GT(0.316)NS(0.645)R 214.3 2.0816e-16 85482200.0 6050.460000000001 7362.5 6400.800000000001 6237.799999999999 6831.5 5833.2300000000005 7313.799999999999 6573.669999999999 3759.11 5744.57 True False 6191.423945854271 6500.49507726661 5531.606517077665 5148.485328007951 6213.592031199284 5774.553002349076 6762.114177625835 6399.314917310503 6378.935115468446 6481.941516350301 0.9551804702706408 1.002862346238316 0.8533872919285874 0.7942813607653219 0.9586004464134517 0.8908678036947911 1.0432235712970899 0.9872528009036525 0.9841087117768608 1.0 12.66221028858658 -7.252586688634891 24.956888525931884 1.0025840051151798 0.9079395702090284 0.39899205252045633 0.0567703989528762 716.1505100006214 2018924.6149761472 0.023753866538036215 0.018139763359766758 5.590019351985229e-08 7.252586688634891 -0.09464443490615138 SAEPRPELGPGQETGTNS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 SAEPRPELGPGQETGTNSR 19 1 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 SAEPRPELGPGQET(0.015)GT(0.019)NS(0.966)R;SAEPRPELGPGQETGTNS(1)R 152.27 9.7315e-06 147998000.0 95118.0 71030.0 79703.0 96805.0 98040.0 79211.0 82556.0 82246.0 60228.0 81540.0 True False 89831.72234752301 76477.77260255227 74574.99575406496 83619.99200206036 85723.33871127947 90121.59624413433 86395.01758161065 82485.32224344168 72275.28291092404 79185.72833363691 1.1344433427325544 0.9658024774404412 0.9417731872068494 1.0559982683968046 1.0825604627906855 1.1381040263268252 1.0910427851038826 1.0416690479362953 0.9127311755775388 1.0 16.27295281594504 -8.150068306147586 6.2481125179584 0.9574915701059187 1.0550564350423075 0.2877827233121891 0.06317751464555424 0.32370444661435943 15.394754937626098 0.04776939778271308 0.017630371315996603 7.078344469192842e-09 8.150068306147586 0.09756486493638883 SAEPSANTTLVS(ph)ETEEEGSVPAFGAAAK ddPTM_A459_Selumetinib_30min_R1 2 SAEPSANTTLVSETEEEGSVPAFGAAAK 28 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 SAEPSANT(0.007)T(0.023)LVS(0.944)ET(0.026)EEEGSVPAFGAAAK;SAEPSANTT(0.001)LVS(0.914)ET(0.084)EEEGSVPAFGAAAK 143.48 2.8379e-13 33423000.0 5423.4 7755.700000000001 3486.7 3540.4 4889.6 4989.5 7892.7 7209.7 3904.5 7778.0 True False 5549.7546679006255 6847.6590384728925 3013.2252910721636 2922.1356015388988 4447.336543328994 4939.310160103528 7297.34728455077 7018.475335593897 6625.651326602988 8776.382064135805 0.6323510789918078 0.7802371168930154 0.3433334224800377 0.3329544657678524 0.5067391677833609 0.562795708300775 0.8314755705965642 0.7997002961248126 0.7549410768793148 1.0 13.099410616925077 -7.216198847471908 3.7228441300479473 0.8331741011778014 0.5151088641401805 0.5747555536310132 0.135007023895161 0.20002413450542125 5.814729101489504 0.0613571022101768 0.044655429524162134 6.07856622360641e-08 7.216198847471908 -0.3180652370376209 SAEPSPTVMS(ph)TSLGSNLSELDR ddPTM_A459_Selumetinib_30min_R2 1 SAEPSPTVMSTSLGSNLSELDR 22 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 SAEPSPT(0.003)VMS(0.321)T(0.321)S(0.321)LGS(0.006)NLS(0.029)ELDR 62.077 0.01171 23411000.0 17538.0 18279.0 21911.0 23090.0 22171.0 21708.0 20622.0 18676.0 16063.0 28596.0 True False 16563.3081701766 19680.9405237513 20501.270114893006 19945.102167528297 19385.680768745187 24698.07995439608 21580.96386171779 18730.344068021754 19276.04883771957 27770.35917866918 0.5964383846680356 0.7087031318942578 0.7382428863448166 0.7182154915320081 0.6980709411794578 0.8893684015929847 0.7771222447239519 0.6744725175326074 0.6941231373242657 1.0 14.76125821648056 -14.522878745280336 0.30672794417922866 3.3434606766851753 0.7134710123377502 0.5740479787888122 0.07167712261022759 229.70702048306802 2.095279227214369 347.69404367903803 0.07390953370844221 3.0000000000000132e-15 14.522878745280336 -2.629989664347425 SAEPSPTVMSTS(ph)LGSNLSELDR ddPTM_A459_Selumetinib_30min_R1 4 SAEPSPTVMSTSLGSNLSELDR 22 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 SAEPSPTVMST(0.263)S(0.735)LGS(0.001)NLSELDR;SAEPSPTVMS(0.007)T(0.045)S(0.947)LGS(0.001)NLSELDR;SAEPSPTVMST(0.004)S(0.988)LGS(0.008)NLSELDR;SAEPSPTVMS(0.003)T(0.191)S(0.798)LGS(0.008)NLSELDR 335.12 2.5852999999999977e-285 8848000.0 10307.33 13122.7 11018.0 11764.199999999999 12296.1 11031.300000000001 10964.8 10264.42 5971.95 8425.86 True False 10547.470734427145 11586.288183422284 9521.816117541828 9709.803311383997 11183.919926052782 10920.335137619011 10137.716308188876 9992.174238064927 10133.962976029374 9507.4012058266 1.1093957755735753 1.2186598558943365 1.0015161779126764 1.021288899161356 1.1763382741435935 1.1486141061267612 1.0662973076150386 1.050989016003788 1.0659025275822784 1.0 13.214835327131725 -14.52287874158063 0.0874834725763832 0.6640238135555196 1.183654828582419 0.21930511387710794 0.06307865404558786 378.02866087351487 2.3006376544939986 23.46785604100318 1.7570624149069145 3.0000000255566733e-15 14.52287874158063 0.5196310150268995 SAEPSPTVMSTS(ph)LGSNLSELDR ddPTM_A459_Selumetinib_30min_R2 5 SAEPSPTVMSTSLGSNLSELDR 22 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 SAEPSPTVMST(0.055)S(0.886)LGS(0.027)NLS(0.032)ELDR;SAEPSPTVMS(0.002)T(0.033)S(0.965)LGSNLSELDR;SAEPSPTVMS(0.001)T(0.27)S(0.701)LGS(0.023)NLS(0.005)ELDR;SAEPSPTVMS(0.015)T(0.015)S(0.922)LGS(0.038)NLS(0.011)ELDR;SAEPSPTVMS(0.002)T(0.067)S(0.891)LGS(0.008)NLS(0.032)ELDR 201.48 1.7006999999999999e-22 26038900.0 61655.8 51357.6 58649.6 72921.5 75087.2 61739.0 59801.399999999994 60276.6 55171.4 69928.0 True False 58229.21746372298 55296.562779288266 54876.148588856275 62989.46590339598 65654.07464791503 70242.98683915872 62582.283594226064 60451.99492667165 66207.22161771538 67908.99694523652 0.8574595426682631 0.8142744741743244 0.8080836274626431 0.927557006241636 0.9667949403060699 1.0343693766498185 0.921561006779322 0.8901912507325299 0.9749403554157412 1.0 16.051315102597044 -5.868190714979495 4.215092352275539 0.9594828183969152 0.8254574957352017 0.7103658820308416 0.039271730738919465 0.1269470876506413 4.0401918877902725 0.012069058459647373 0.018657587126702388 1.3545944285521573e-06 5.868190714979495 -0.13402532266171352 SAES(ph)PSWTPAEHVAK ddPTM_A459_Selumetinib_30min_R1 2 SAESPSWTPAEHVAK 15 0 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 SAES(0.975)PS(0.025)WTPAEHVAK;SAES(0.99)PS(0.01)WTPAEHVAK 227.91 9.8346e-14 49634000.0 10766.0 13257.3 15070.900000000001 16614.9 14011.0 12265.3 12862.3 11927.099999999999 6204.3 9718.599999999999 True False 11016.826853010683 11705.12915284843 13024.354558527972 13713.41961530016 12743.707523842957 12141.922218001366 11892.086355502859 11610.754563319126 10528.243955856806 10966.076977180539 1.0046278970990037 1.067394399766279 1.187694978398431 1.250531037109862 1.1621026872564832 1.1072256964151956 1.0844430857315033 1.0587883513384144 0.9600738694215967 1.0 13.420759885435851 -7.810041855834434 1.4529120066200085 0.9813453888513348 1.136903598713907 0.4471338694252043 0.0642067085427091 0.4325087903839672 1.6817583263988527 0.05952044379453681 0.022335164766768393 1.5486673563939187e-08 7.810041855834434 0.15555820986257207 SAES(ph)PSWTPAEHVAK ddPTM_A459_Selumetinib_30min_R2 4 SAESPSWTPAEHVAK 15 0 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 S(0.048)AES(0.885)PS(0.066)WTPAEHVAK;S(0.006)AES(0.497)PS(0.497)WTPAEHVAK;S(0.179)AES(0.689)PS(0.132)WTPAEHVAK;S(0.003)AES(0.911)PS(0.086)WTPAEHVAK 199.15 2.2975e-05 79984600.0 395844.0 371916.0 445243.0 442739.0 470693.0 339543.0 346921.0 350368.0 317264.0 407353.0 True False 373844.57516908366 400440.7613015754 416596.55012392375 382437.18443262513 411560.3372911903 386311.9661855308 363053.51391091984 351387.5128734552 380725.66509682185 395591.66045979894 0.9450264313827079 1.0122578439498455 1.053097402608818 0.9667473373632693 1.0403665658998746 0.9765422398857391 0.9177481484036852 0.8882581408946666 0.962420857543614 1.0 18.59365248713619 -7.054704325408847 4.833997062306511 0.9336514334299333 1.0051588797247377 0.33080322199689016 0.040324416316171396 0.2128975423886872 10.560713932527168 0.015193887934060603 0.011949779842461625 8.816489093286508e-08 7.054704325408847 0.07150744629480443 SAES(ph)PTSPVTSETGSTFK ddPTM_A459_Selumetinib_30min_R1 2 SAESPTSPVTSETGSTFK 18 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SAES(1)PTSPVTSETGSTFK;SAES(0.974)PT(0.024)S(0.002)PVTSETGSTFK 294.94 2.830799999999999e-81 74798000.0 9313.5 11451.599999999999 8224.5 8949.1 9367.3 8407.8 9548.1 9318.1 4975.98 7282.7 True False 9530.486429083687 10110.841348295586 7107.658073944702 7386.307680412317 8520.02936893114 8323.225165671596 8827.879129780593 9070.953718545503 8443.874628800086 8217.505484505251 1.1597785297562824 1.230402750245846 0.8649410806414121 0.8988503499437606 1.0368145643463607 1.0128651792646428 1.074277242214958 1.1038573367123996 1.0275471850577613 1.0 13.00448479884761 -5.239141817145572 24.879409777706357 1.0065758323514884 1.195090681315683 0.544199672966478 0.07045795931657334 641.9354093790676 716262.730910229 0.020043711433067712 0.05293966119831162 5.765781533321803e-06 5.239141817145572 0.18851484896419457 SAES(ph)PTSPVTSETGSTFK ddPTM_A459_Selumetinib_30min_R2 2 SAESPTSPVTSETGSTFK 18 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SAES(0.999)PT(0.001)SPVTSETGSTFK;SAES(1)PTSPVTSETGSTFK 289.1 1.1100999999999997e-80 59575800.0 172914.0 176141.0 231499.0 231272.0 240732.0 183561.0 241638.0 200800.0 172874.0 230204.0 True False 163304.13210958583 189650.44831741758 216604.60637705325 199772.35463354742 210489.09398861413 208844.86154914793 252874.64579661321 201384.29475577056 207453.63050313984 223557.41237817743 0.7304796131444523 0.8483299493402543 0.9688992374390049 0.8936064902004037 0.9415437929320076 0.9341889375417298 1.1311396169179206 0.9008168980552609 0.9279657887263614 1.0 17.77028585580809 -3.875578887877479 0.7474853120259488 0.9723947037338786 1.1762662585478559e-14 0.5758168036313082 0.06368928529083759 6.925157274458901 1.082899699995058 0.024946298316832954 7.744608391432873 0.0001331745114100658 3.875578887877479 -0.9723947037338668 SAES(ph)PTSPVTSETGSTFKK ddPTM_A459_Selumetinib_30min_R1 1 SAESPTSPVTSETGSTFKK 19 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.032)AES(0.552)PT(0.394)S(0.022)PVTSETGSTFKK 116.04 0.00024128 12926000.0 2139.7 1985.4 3028.9 2826.0 2432.7 2301.4 1850.1 2221.8 1460.6 1924.6 True False 2189.5508468685643 1752.9484450125813 2617.5920165567654 2332.4921505900274 2212.662714528068 2278.2500055040123 1710.5454674759435 2162.8706465764903 2478.5315219967547 2171.6411571915355 1.0082470760041178 0.8071998632037226 1.2053520020508148 1.0740688639399851 1.0188896573454076 1.0490913740326915 0.7876740877798145 0.9959613444486438 1.141317253906766 1.0 11.084570016022406 SAES(ph)PTSPVTSETGSTFKK ddPTM_A459_Selumetinib_30min_R2 2 SAESPTSPVTSETGSTFKK 19 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.039)AES(0.727)PT(0.233)S(0.001)PVTSETGSTFKK;S(0.001)AES(0.767)PT(0.183)S(0.049)PVTSETGSTFKK 153.58 5.8031e-06 56988000.0 63066.0 87036.0 89114.0 88444.0 80870.0 48873.0 50030.0 48781.0 36807.0 79653.0 True False 59561.04419320086 93711.38133515084 83380.502259987 76397.77462558997 70710.38761302707 55604.81212507833 52356.49413256429 48922.94463387074 44169.42847350708 77353.2109266518 0.7699880002354149 1.2114737088808152 1.077919083915604 0.987648395074798 0.9141234961800925 0.7188429731482533 0.6768496550480625 0.6324617174620026 0.5710096315896908 1.0 16.23917355864213 -6.615471739024386 2.047650744655301 0.6869805011556382 1.03310614261967 0.46059640987214456 0.14808580123923712 0.25149797430776644 2.1514380472698047 0.054082987737309046 0.054890280358429175 2.4239756955229854e-07 6.615471739024386 0.3461256414640317 SAESPS(ph)WTPAEHVAK ddPTM_A459_Selumetinib_30min_R2 1 SAESPSWTPAEHVAK 15 0 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 SAES(0.312)PS(0.632)WT(0.056)PAEHVAK 140.27 0.00039017 5473200.0 17645.0 18699.0 20221.0 23649.0 24516.0 14836.0 14720.0 16119.0 12279.0 19097.0 True False 16664.361538531535 20133.153173238457 18920.00287496015 20427.96540319952 21436.080904179213 16879.524332201057 15404.509167126655 16165.903621355903 14735.143103925708 18545.619990035157 0.8985604982462463 1.0856015158326497 1.0201871323323866 1.1014981119086757 1.1558567961436255 0.9101623100910448 0.8306278881700224 0.8716831052314287 0.7945349420425483 1.0 14.178790878266504 -6.922103815057321 6.586128920681507 0.8644196202049342 1.0545498288255994 0.5367843488940078 0.07968596476658785 0.15522110006016615 10.56584205941058 0.027732710057571202 0.024415654619454056 1.196454493045415e-07 6.922103815057321 0.1901302086206652 SAESPT(ph)SPVTSETGSTFK ddPTM_A459_Selumetinib_30min_R1 2 SAESPTSPVTSETGSTFK 18 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SAESPT(0.71)S(0.285)PVTS(0.005)ETGSTFK;SAESPT(0.496)S(0.496)PVTS(0.009)ETGSTFK 243.83 4.699100000000001e-25 27111000.0 7363.2 9513.5 8295.9 8086.599999999999 7776.299999999999 7659.0 10533.7 9592.1 5583.5 7418.2 True False 7534.748233706882 8399.654997293837 7169.36234611683 6674.427114282134 7072.935038017275 7581.9574138156 9739.134528269477 9337.686348468069 9474.791697294857 8370.398229387018 0.90016604075702 1.003495265948531 0.856513889739014 0.7973846561862944 0.8449938514496748 0.9058060567771629 1.1635210489839136 1.1155605853596153 1.1319403734018896 1.0 13.031080546612715 -7.207535558096598 6.299102074209523 1.1121990669008188 0.8818962711971172 0.7384881191212812 0.0634910899350665 0.11616106094037085 10.538231915730837 0.02604482466604315 0.019948837793728236 6.201038702340705e-08 7.207535558096598 -0.2303027957037016 SAESPT(ph)SPVTSETGSTFK ddPTM_A459_Selumetinib_30min_R2 2 SAESPTSPVTSETGSTFK 18 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SAES(0.003)PT(0.73)S(0.26)PVT(0.001)S(0.007)ETGSTFK;SAES(0.096)PT(0.888)S(0.013)PVT(0.001)S(0.002)ETGSTFK 127.88 0.0016522000000000002 54881500.0 50397.0 51127.0 57569.0 53390.0 57024.0 46844.0 53804.0 49174.0 43145.0 53463.0 True False 47596.13649517561 55048.27650078415 53865.07321638791 46118.18989711285 49860.135318971916 53296.33579250648 56305.99261060339 49317.08819880607 51775.20557202331 51919.38427644391 0.9167315282814366 1.060264432406989 1.037475192879488 0.8882653471304147 0.9603375697502968 1.02652095234279 1.0844888358229183 0.9498781406231254 0.9972230274601693 1.0 15.663985653745742 -6.7638966146825314 24.99435214195072 1.0130437412920203 0.9764015097960939 0.10406324269204226 0.05660909023477704 184.46383561358599 1876306.5997272006 0.020629539467046477 0.019052092551627733 1.7222785206036027e-07 6.7638966146825314 -0.03664223149592649 SAESPT(ph)SPVTSETGSTFKK ddPTM_A459_Selumetinib_30min_R2 1 SAESPTSPVTSETGSTFKK 19 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.033)AES(0.111)PT(0.462)S(0.387)PVT(0.006)S(0.001)ETGSTFKK 61.87 0.042436 5996500.0 8745.3 10260.0 16620.0 18124.0 15530.0 12695.0 8854.5 8099.3 9748.2 15663.0 True False 8259.271236209677 11046.909008900295 15550.687294487785 15655.479934356128 13578.982560038465 14443.62101626397 9266.251794858897 8122.867622088705 11698.11238746547 15210.768492638676 0.5429884256148393 0.7262558110884733 1.0223472470844333 1.0292366189080238 0.8927216640375586 0.9495655017860558 0.6091902456699242 0.5340208567384223 0.7690678083179576 1.0 13.892805423638217 -7.261174052299128 24.99798321394931 0.6892381324648189 0.8709048702433446 0.10063965445327006 0.17792288995150973 43.958187263259816 4141803.765944504 0.07411495184674102 0.05375270892581327 5.480572758612199e-08 7.261174052299128 0.1816667377785257 SAESPTS(ph)PVTSETGSTFK ddPTM_A459_Selumetinib_30min_R2 1 SAESPTSPVTSETGSTFK 18 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SAESPT(0.008)S(0.992)PVTSETGSTFK 168.55 1.1923e-06 0.0 23110.0 19513.0 23574.0 24336.0 28722.0 18885.0 25759.0 26150.0 21756.0 30643.0 True False 21825.638716659887 21009.584355815914 22057.274505430505 21021.394818058423 25113.68558206213 21486.2373290386 26956.84454049017 26226.09217063444 26107.807913430053 29758.256969924467 0.733431354488209 0.7060085668676596 0.7412152710329422 0.7064054470429483 0.843923271697115 0.7220260699661918 0.9058610041486779 0.8813047147600127 0.8773298765386769 1.0 14.86100240550849 -7.601936275272218 0.4176262384479835 0.9996476613200206 0.6966009062513586 0.7968818954029189 0.044136593497629384 0.44598300852688677 0.19765635145203136 0.04754071003325872 0.04311468745580421 2.5007122683102653e-08 7.601936275272218 -0.30304675506866197 SAESPTS(ph)PVTSETGSTFKK ddPTM_A459_Selumetinib_30min_R1 3 SAESPTSPVTSETGSTFKK 19 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.001)AES(0.032)PT(0.254)S(0.712)PVT(0.001)SETGSTFKK;S(0.008)AES(0.204)PT(0.246)S(0.535)PVT(0.006)SETGSTFKK;S(0.001)AES(0.034)PT(0.234)S(0.724)PVT(0.007)SETGSTFKK 125.75 0.00019646 71811000.0 4372.8 4784.0 7547.1 6891.700000000001 5841.299999999999 5375.0 5838.3 5962.5 3633.24 4491.7 True False 4474.677732012363 4223.887055978737 6522.2452732528545 5688.1939682311695 5312.955446365274 5320.932380109523 5397.912330557706 5804.355131070447 6165.342918649516 5068.253447863049 0.8828835767672673 0.833400914028811 1.2868822248821947 1.122318373922186 1.0482813263029298 1.0498552282054903 1.0650438826877635 1.1452377413204866 1.2164630246044696 1.0 12.30727295571392 -5.2389343067395195 24.99218825477353 1.1154636441751011 0.8581421722429765 0.6169455876176237 0.08150761314963376 524.8965719130221 582902.7809145169 0.02112890638070358 0.055809189578128526 5.76853714179256e-06 5.2389343067395195 -0.2573214719321246 SAFS(ph)PYQTPVAHFPPPPEEPTATAAFGAR ddPTM_A459_Selumetinib_30min_R2 1 SAFSPYQTPVAHFPPPPEEPTATAAFGAR 29 0 A0A0A0MQV9;Q9UPS6-2;Q9UPS6 A0A0A0MQV9 SETD1B Histone-lysine N-methyltransferase;Histone-lysine N-methyltransferase SETD1B 1 S(0.031)AFS(0.452)PY(0.258)QT(0.258)PVAHFPPPPEEPTATAAFGAR 96.461 1.086e-07 5457400.0 4029.3 3656.9 4773.8 6060.5 5232.3 5466.0 4986.2 2884.0 3838.9 3210.5 True False 3805.367636565888 3937.3724712132016 4466.658905320448 5235.049445054366 4574.971696644511 6218.8918845922735 5218.068179967859 2892.391962528098 4606.787267828029 3117.804523119228 1.220527973562237 1.2628670085044431 1.4326295546109957 1.6790819970383921 1.4673696387057167 1.994638162360013 1.6736354512525398 0.927701509533505 1.4775741178344106 1.0 11.606314762932868 -7.753201920071014 24.999986014278164 1.1519783372460826 1.539570616584768 0.3486322365192128 0.24878427700688324 217.39208553472423 659771.7546887352 0.12701602763146608 0.07173637362536038 1.7652169131873374e-08 7.753201920071014 0.38759227933868545 SAFSPYQT(ph)PVAHFPPPPEEPTATAAFGAR ddPTM_A459_Selumetinib_30min_R2 1 SAFSPYQTPVAHFPPPPEEPTATAAFGAR 29 0 A0A0A0MQV9;Q9UPS6-2;Q9UPS6 A0A0A0MQV9 SETD1B Histone-lysine N-methyltransferase;Histone-lysine N-methyltransferase SETD1B 1 S(0.016)AFS(0.125)PY(0.324)QT(0.534)PVAHFPPPPEEPTATAAFGAR 74.206 9.2647e-05 4956600.0 4890.9 4418.0 4182.7 5398.2 4998.0 5576.8 3896.7 3025.4 2944.0 5213.4 True False 4619.083357823966 4756.8463938909845 3913.5896357794286 4662.955847585591 4370.10655731309 6344.953578850014 4077.9042711645675 3034.2034131180662 3532.882262232856 5062.875595960065 0.9123438390447074 0.9395542718226619 0.772997392806232 0.9210093669507521 0.8631668850011303 1.2532311842528754 0.8054521968540057 0.5993043588784241 0.6978015152203086 1.0 12.305741319710423 -7.513012876293183 24.991737809746034 0.7296073881527539 0.939263338002377 0.22466702261733096 0.1497235626843685 615.4470732289103 1559032.1227353006 0.0661619991534805 0.041082698393009966 3.068930997041429e-08 7.513012876293183 0.2096559498496231 SAGAENPRPFS(ph)PPRAPPPPPPPPPPPPR ddPTM_A459_Selumetinib_30min_R1 2 SAGAENPRPFSPPRAPPPPPPPPPPPPR 28 2 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.002)AGAENPRPFS(0.998)PPRAPPPPPPPPPPPPR;S(0.007)AGAENPRPFS(0.993)PPRAPPPPPPPPPPPPR 125.35 4.1845e-12 36173000.0 1558.21 1755.8000000000002 1904.3500000000001 2133.33 1606.96 1422.7 1762.68 1581.3700000000001 970.56 1388.81 True False 1594.5132612511397 1550.2301197507247 1645.7497298457788 1760.7839630637725 1461.6107517318308 1408.388929708246 1629.7196284581905 1539.4269305863093 1646.9694331022647 1567.077291654981 1.0175077322237143 0.9892493037873938 1.050203291573265 1.1236101578654227 0.932698571739389 0.8987360975800082 1.0399739930741088 0.9823554580135161 1.0509816215656536 1.0 10.613860623079717 -4.4228131959704715 17.186585922253897 1.0069929130006252 1.5691851236212353 0.0023618891436625322 0.060580033563020996 9480899.005154274 14476882.275351388 0.015971326999254708 205144778.89932385 3.777346318056488e-05 4.4228131959704715 0.5621922106206101 SAGAENPRPFS(ph)PPRAPPPPPPPPPPPPR ddPTM_A459_Selumetinib_30min_R2 2 SAGAENPRPFSPPRAPPPPPPPPPPPPR 28 2 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 S(0.067)AGAENPRPFS(0.933)PPRAPPPPPPPPPPPPR;S(0.22)AGAENPRPFS(0.78)PPRAPPPPPPPPPPPPR 90.592 5.7536e-06 12126800.0 50649.0 50606.0 58148.0 62224.0 72808.0 44921.0 40028.0 47886.0 37686.0 55795.0 True False 47834.13134401153 54487.31747606317 54406.82098675544 53748.98385761285 63661.20812822152 51108.459997762395 41889.38131397728 48025.34033204597 45224.253034819114 54184.05337718032 0.8828082869886757 1.005596925294086 1.0041113131205675 0.9919705246756106 1.1749067144362537 0.9432380342975003 0.7730942722645967 0.8863371663566222 0.834641379078985 1.0 15.725580701631682 -7.00191908614788 24.99834343114686 0.8632062684776611 1.0149002414300994 0.36918576224151145 0.08483087209034937 72.86460127976879 949160.1568290376 0.029750868666813694 0.025849688978861012 9.955908896370407e-08 7.00191908614788 0.15169397295243825 SAGALEEGTSEGQLCGRS(ph)AR ddPTM_A459_Selumetinib_30min_R1 1 SAGALEEGTSEGQLCGRSAR 20 1 H7BXQ8;C9J5N7;Q8N2F6-3;Q8N2F6 H7BXQ8 ARMC10 Armadillo repeat-containing protein 10 1 SAGALEEGTSEGQLCGRS(1)AR 64.454 0.0099109 17465000.0 1558.3 2002.3 2249.3 2152.6 2122.9 1770.4 1856.8 1502.1 1224.4 1469.4 True False 1594.6053580760301 1767.8697851559846 1943.8574145204973 1776.6888193064729 1930.884069828436 1752.5913833945863 1716.740081081744 1462.259428491559 2077.7173733621958 1658.0118031680572 0.9617575429976597 1.0662588660575367 1.1724026395989815 1.0715779078964653 1.1645780000715231 1.0570439728147958 1.0354209046048233 0.8819354757894587 1.2531378663241017 1.0 10.69523856188864 -6.992082882994547 24.687195684744673 1.0347059228620643 1.092079313457331 0.03927946913308189 0.10101237497305028 478.60958595843636 1492391.0118751866 0.03471250322011123 0.030551120049038632 1.0183970133785335e-07 6.992082882994547 0.05737339059526669 SAGALEEGTSEGQLCGRS(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 SAGALEEGTSEGQLCGRSAR 20 1 H7BXQ8;C9J5N7;Q8N2F6-3;Q8N2F6 H7BXQ8 ARMC10 Armadillo repeat-containing protein 10 1 SAGALEEGTSEGQLCGRS(1)AR 64.275 0.010027 2285800.0 4388.4 5066.9 4075.0 6117.1 5938.6 3836.4 4320.1 3190.3 4272.6 6508.5 True False 4144.510296157083 5455.514937348622 3812.818936524533 5283.940427413918 5192.539976242398 4364.829276628212 4520.99321011575 3199.583244817403 5127.239386418516 6320.582693886153 0.6557164895834736 0.8631348091728467 0.6032385179000412 0.835989446435853 0.8215286829907468 0.6905738739642272 0.7152810791462105 0.5062164992971824 0.8111972637234938 1.0 12.625841851107031 -8.535500149039793 23.67702410818179 1.0000000099544115 0.7163186981867431 0.41868475495291624 0.10402488202409386 988.5278981178174 1854421.3716501321 0.09972474033002031 0.025748817221390476 2.9140691347296977e-09 8.535500149039793 -0.2836813117676684 SAGEALGSSGT(ph)PPVR ddPTM_A459_Selumetinib_30min_R1 1 SAGEALGSSGTPPVR 15 0 W0Z7M9;A0A499FIJ6;A0A494BZX7;B0QY83;Q969V6;E7ER32;A0A087X287;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 SAGEALGS(0.001)S(0.002)GT(0.997)PPVR 116.58 0.0051349 0.0 982.82 1097.1 950.9 1100.7 1156.2 969.1 1249.3 1108.0 605.26 834.84 True False 1005.7177937651833 968.6510219720467 821.7730029198157 908.483407697963 1051.62191414369 959.3517338723984 1155.0642951828 1078.6122407087728 1027.0820135586434 941.999846030231 1.0676411445325305 1.028292123458543 0.8723706340111684 0.9644199110291656 1.1163716412220528 1.0184202661128785 1.2261831040105406 1.1450237972482191 1.0903207870860756 1.0 9.87958301380446 -6.2632218326552715 24.765280029718454 1.1089293017580817 0.9784881534661717 0.35632668569810555 0.07576143263759372 148.4365103659761 2062361.2979460666 0.02383333955339956 0.028455081719265835 5.454791653998208e-07 6.2632218326552715 -0.13044114829191 SAGGSSPEGGEDS(ph)DREDGNYCPPVK ddPTM_A459_Selumetinib_30min_R1 2 SAGGSSPEGGEDSDREDGNYCPPVK 25 1 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EID7;K7ENB9 Q9H6Z4 RANBP3 Ran-binding protein 3 1 SAGGS(0.001)S(0.009)PEGGEDS(0.978)DREDGNY(0.012)CPPVK;SAGGSSPEGGEDS(1)DREDGNYCPPVK 153.36 1.1313e-10 16979300.0 2739.8999999999996 4031.8 2419.3999999999996 2352.2 2674.8999999999996 2593.7 3296.8 2637.7 1454.52 2544.9 True False 2803.7343390826645 3559.7549816670294 2090.8587688129137 1941.4324262625116 2432.9557672919514 2567.609732891177 3048.1197217310914 2567.7396275428955 2468.2142060623833 2871.5627044252005 0.9763792846180898 1.2396577571443226 0.7281257573065743 0.6760891633223546 0.8472584504397772 0.8941506758443342 1.0614846463334437 0.8941959106746648 0.8595369351533784 1.0 11.487620349912262 -5.260503507624209 24.99998424337356 0.8662751241270026 1.1080185178576931 0.3795294847541709 0.12160037665387619 85.94643176364815 2295803.7692701877 0.033455471047749076 0.07872287701443517 5.489041223083422e-06 5.260503507624209 0.24174339373069054 SAGGSSPEGGEDS(ph)DREDGNYCPPVK ddPTM_A459_Selumetinib_30min_R2 4 SAGGSSPEGGEDSDREDGNYCPPVK 25 1 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EID7;K7ENB9 Q9H6Z4 RANBP3 Ran-binding protein 3 1 SAGGSS(0.002)PEGGEDS(0.996)DREDGNY(0.001)CPPVK;SAGGSS(0.001)PEGGEDS(0.981)DREDGNY(0.018)CPPVK;SAGGS(0.001)S(0.005)PEGGEDS(0.981)DREDGNY(0.013)CPPVK;SAGGSSPEGGEDS(1)DREDGNYCPPVK 111.4 9.0735e-08 67369000.0 58710.7 50406.5 60592.6 68738.4 75929.9 58639.7 61311.6 58939.3 64255.0 56367.1 True False 55447.79433155358 54272.51646755676 56694.13808423468 59376.11133964608 66390.90714008137 66716.78639680306 64162.710886630586 59110.80360507359 77107.7954347052 54739.63536368599 1.0129368594285042 0.9914665325586162 1.0357054391678555 1.0847005272350774 1.2128489110127463 1.2188021705578012 1.1721435566813405 1.079853806338787 1.4086282256432079 1.0 15.740298204081437 -5.986906463953885 2.4406186301641424 1.1872704060482835 1.008297268919465 0.36930001659599854 0.09942171621064257 0.29455799194685156 3.5342444083971567 0.029252870283926927 0.045082849845400966 1.0306080634483939e-06 5.986906463953885 -0.17897313712881857 SAGGSSPEGGEDS(ph)DREDGNYCPPVKR ddPTM_A459_Selumetinib_30min_R1 3 SAGGSSPEGGEDSDREDGNYCPPVKR 26 2 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EID7;K7ENB9 Q9H6Z4 RANBP3 Ran-binding protein 3 1 SAGGS(0.091)S(0.025)PEGGEDS(0.883)DREDGNYCPPVKR;S(0.002)AGGS(0.064)S(0.248)PEGGEDS(0.683)DREDGNY(0.003)CPPVKR;SAGGS(0.002)S(0.002)PEGGEDS(0.993)DREDGNY(0.003)CPPVKR 89.29899999999998 5.9755e-05 25445100.0 1958.72 2404.85 2784.18 2836.92 2365.99 2480.5499999999997 2324.0800000000004 2094.52 1477.3300000000002 2158.12 True False 2004.3543649943426 2123.2890440155657 2406.1036484060273 2341.505177583815 2151.986622249462 2455.5979191591946 2148.7727744724566 2038.966525640196 2506.9211100858997 2435.13572386896 0.8230975979481796 0.8719386862930455 0.9880778409275658 0.9615501734185131 0.8837234824966433 1.0084028972552397 0.8824037007097377 0.837311245387453 1.0294790083005667 1.0 11.24978646875444 -5.041357994770306 4.789898892405011 0.940802463746976 0.8319008636490891 0.3196035255354085 0.060101369985132276 0.21919661414126598 11.877349778192102 0.015150595286960753 0.048523018837579424 9.09163527963992e-06 5.041357994770306 -0.10890160009788685 SAGGSSPEGGEDS(ph)DREDGNYCPPVKR ddPTM_A459_Selumetinib_30min_R2 5 SAGGSSPEGGEDSDREDGNYCPPVKR 26 2 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3;K7EID7;K7ENB9 Q9H6Z4 RANBP3 Ran-binding protein 3 1 SAGGS(0.005)S(0.015)PEGGEDS(0.98)DREDGNYCPPVKR;S(0.001)AGGS(0.01)S(0.014)PEGGEDS(0.975)DREDGNY(0.001)CPPVKR;SAGGSS(0.001)PEGGEDS(0.998)DREDGNYCPPVKR;SAGGS(0.003)S(0.004)PEGGEDS(0.99)DREDGNY(0.003)CPPVKR;SAGGS(0.002)S(0.011)PEGGEDS(0.986)DREDGNY(0.001)CPPVKR 99.414 2.6614e-06 111199000.0 84580.0 92899.0 87743.0 107274.0 100116.0 62435.0 62523.1 71189.0 52080.0 99507.0 True False 79879.38220056662 100024.05458263439 82097.71090735508 92663.09614202814 87538.53303160405 71034.85452149977 65430.548037172295 71396.14820402669 62497.45523678237 96633.97435976507 0.8266179956872967 1.0350816598958061 0.8495739873194912 0.9589080523279164 0.9058773957252447 0.7350919279904538 0.6770967299096748 0.7388307132874532 0.6467441254574341 1.0 16.560242877338354 -6.7430945330475565 5.913323357627081 0.7375315492096263 0.921772299770846 0.346816577257796 0.10458722615540868 0.15576691880408997 17.76223302330381 0.03306615813299964 0.031775654131949896 1.806780800530378e-07 6.7430945330475565 0.1842407505612197 SAGQGEVLVYVEDPAGHQEEAK ddPTM_A459_Selumetinib_30min_R1 1 SAGQGEVLVYVEDPAGHQEEAK 22 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 114.19 4.9529e-05 10383000.0 1449.6 1716.1 1620.9 1575.9 1877.4 1404.7 1475.4 1474.4 1005.6 1355.7 False True 1483.3728595694122 1515.1782142067548 1400.790682966377 1300.6986483067315 1707.5895014818916 1390.5699933655526 1364.1093901486452 1435.2941224738388 1706.4297538819226 1529.7173006362698 0.969703917810447 0.990495572990207 0.9157186640850129 0.8502869437154954 1.1162778251717738 0.9090372402712316 0.8917395322529583 0.9382740993233477 1.1155196801213865 1.0 10.579049344995665 -8.244556471790803 24.380238876069456 1.0577598397016927 0.9472718988314097 0.2691356787008262 0.07255016782858134 678.0069388609741 979100.2500009249 0.04909442730339442 0.018438451839788664 5.6943417515943254e-09 8.244556471790803 -0.11048794087028302 SAGQGEVLVYVEDPAGHQEEAK ddPTM_A459_Selumetinib_30min_R2 2 SAGQGEVLVYVEDPAGHQEEAK 22 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 ; 186.06 2.0284e-21 12006900.0 69930.0 62692.0 79090.0 79287.0 83112.0 57115.0 58579.0 61212.0 51266.0 67731.0 False True 66043.57055197003 67500.27481344798 74001.43550668113 68487.97382229597 72670.72752929277 64982.07281165157 61303.03957208639 61390.11678580786 61520.63249172201 65775.4300437279 1.0040766059311792 1.0262232381996346 1.1250619791840895 1.0412394685487385 1.1048308993340041 0.9879383953620842 0.9320051504236728 0.9333290066670084 0.9353132689641516 1.0 16.00526115539862 -6.9559546051032575 5.085296495090272 0.9461957250105782 1.0606118327418692 0.6561406907677498 0.03783173347776064 0.11605747465739383 6.928314625822089 0.013875772482763027 0.01200112943887608 1.1067394605520121e-07 6.9559546051032575 0.11441610773129096 SAGQSS(ph)PAKEGPLDLYPK ddPTM_A459_Selumetinib_30min_R2 1 SAGQSSPAKEGPLDLYPK 18 1 Q5VV67-2;Q5VV67;E7EVG6 Q5VV67-2 PPRC1 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 1 S(0.008)AGQS(0.244)S(0.748)PAKEGPLDLYPK 72.187 0.011156 4517500.0 26443.0 35273.0 32044.0 27660.0 28817.0 20968.0 17526.0 18522.0 10231.0 31078.0 True False 24973.40391971603 37978.325679428846 29982.32392686925 23892.660283838577 25196.750832751357 23856.151671447256 18340.993727110173 18575.895953517836 12277.485878024576 30180.697389658748 0.8274627851466756 1.2583647484713827 0.9934271411880141 0.7916536843189471 0.8348631082787665 0.7904440166986147 0.607706094074374 0.615489288192617 0.40679927701840946 1.0 14.881338522358309 -6.268426260788128 0.9445411566522317 0.6357221559320162 1.0586910049485316 0.3917196240904096 0.1767654472491373 0.5195716437697048 0.9861706967769187 0.08304608406211532 0.13131272850751974 5.389813516848932e-07 6.268426260788128 0.42296884901651544 SAKSEESLT(ph)SLHAVDGDSK ddPTM_A459_Selumetinib_30min_R1 1 SAKSEESLTSLHAVDGDSK 19 1 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 1 S(0.027)AKS(0.094)EES(0.286)LT(0.534)S(0.058)LHAVDGDSK 68.569 0.026261000000000003 5097800.0 1742.8 1954.0 2334.1 2556.0 2649.8 1882.0 2057.5 1763.8 824.67 1453.5 True False 1783.403849101526 1725.2247716100442 2017.1420402935537 2109.642582062318 2410.1260578601864 1863.0687887192785 1902.3011184972463 1717.018294370155 1399.4047584862803 1640.0708832889416 1.087394372568306 1.0519208585365152 1.2299115000739764 1.286311831737244 1.4695255445465887 1.135968455816461 1.1598895742130593 1.046917125268943 0.8532587053066647 1.0 10.679542453627105 -7.836784038323553 2.077337806390608 0.9273536564377636 1.2159968598933366 0.4900019261419216 0.11490310029808005 0.3050116320042403 2.542789175780551 0.09396051251809485 0.036432873754485395 1.4561830168991772e-08 7.836784038323553 0.28864320345557304 SALAPNLLT(ph)SGK ddPTM_A459_Selumetinib_30min_R1 1 SALAPNLLTSGK 12 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 SALAPNLLT(0.767)S(0.233)GK 149.69 0.0013313 15225000.0 3708.7 4875.8 4721.5 4658.3 3639.6 3526.2 3986.9 3422.3 2260.5 2989.6 True False 3795.105494126017 4304.939069302076 4080.346233343052 3844.815352120849 3310.3988226235715 3490.7296295334318 3686.164923128393 3331.5294868029155 3835.9033996122544 3373.3442811700165 1.1250276217907162 1.2761635666220654 1.209584878756525 1.1397636978776762 0.9813403396451984 1.0347979152376054 1.0927330909283524 0.9876043501991448 1.1371218232969103 1.0 11.71996385098425 -6.018959384535081 3.897021199285212 1.0410742018599084 1.2085957614385776 0.6360724797180562 0.056468823530420466 0.1320357859462338 4.459776313901665 0.016127032920971184 0.02286652738750259 9.572835928103004e-07 6.018959384535081 0.1675215595786692 SALAPNLLT(ph)SGK ddPTM_A459_Selumetinib_30min_R2 1 SALAPNLLTSGK 12 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 SALAPNLLT(0.709)S(0.291)GK 155.09 0.00099322 8168900.0 93625.0 98783.0 93251.0 107040.0 114090.0 97235.0 89621.0 92081.0 76266.0 99286.0 True False 88421.69731057034 106359.33846259247 87251.33218401227 92460.96734570077 99756.99422245914 110628.23863855278 93788.55408064238 92348.94046516984 91521.3310500855 96419.35520399173 0.9170533978732697 1.1030911608729492 0.904915117918151 0.9589461280889474 1.0346158612179688 1.147365468318054 0.9727150101991096 0.9577842567997865 0.9492008202757256 1.0 16.557035161418916 -4.501465436526453 18.41929608493275 1.0024234241611687 0.7053545947297927 0.11920828490651003 0.07020715857695145 7316548.23044709 158256337.1502134 0.018164924671836443 64040506.96202179 3.1516251933831125e-05 4.501465436526453 -0.297068829431376 SALAPNLLT(ph)SGKK ddPTM_A459_Selumetinib_30min_R2 1 SALAPNLLTSGKK 13 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 SALAPNLLT(0.731)S(0.269)GKK 119.92 0.0039125 13270000.0 56638.0 60563.0 52720.0 57646.0 53436.0 51783.0 49114.0 43701.0 37718.0 49945.0 True False 53490.286699878096 65207.98735926201 49328.05259719594 49794.51535510333 46722.891956098894 58915.63821072839 51397.898317544714 43828.16267490998 45262.6539289738 48502.95807730567 1.1028252465473023 1.34441258727625 1.0170112206058692 1.0266284228631815 0.9632998441379669 1.214681342049832 1.059685849172848 0.9036183443709795 0.9331936797923259 1.0 15.565785115989863 -4.577674632772029 0.3375401651568478 0.9634027019091189 1.4357169442378046 0.29690534391344714 0.10704643154342579 10.014059082194962 0.8269952025565658 0.1112323729408016 1.99451624000259 2.6443891540026243e-05 4.577674632772029 0.4723142423286857 SALAPNLLTS(ph)GK ddPTM_A459_Selumetinib_30min_R1 1 SALAPNLLTSGK 12 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 SALAPNLLT(0.026)S(0.974)GK 136.33 0.0014159 13204000.0 2611.7 3237.9 3090.4 3665.9 3154.9 2303.3 2873.4 2671.7 1648.0 2430.0 True False 2672.547528516442 2858.805162741129 2670.7406543520847 3025.719382465669 2869.5398520428334 2280.130893229072 2656.6571246123876 2600.83783709533 2796.5356348422906 2741.9141702044253 0.9747013810856043 1.0426311639536072 0.974042398326774 1.1035062349307907 1.0465461987195948 0.83158361337732 0.9689060122601572 0.9485482315084366 1.019920924305881 1.0 11.420967695984013 SALAPNLLTS(ph)GK ddPTM_A459_Selumetinib_30min_R2 1 SALAPNLLTSGK 12 0 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 SALAPNLLT(0.19)S(0.81)GK 148.41 0.0006037000000000001 7514600.0 65950.0 73241.0 68214.0 77831.0 65904.0 64247.0 63555.0 64299.0 56979.0 68129.0 True False 62284.76301876767 78858.34919306693 63825.185505787646 67230.28353403625 57624.5503307647 73096.44107380162 66510.43343184331 64486.0994447275 68376.3921262792 66161.93874959962 0.9413986983436846 1.1918990084543757 0.9646813063828769 1.0161474225911056 0.8709622393148723 1.1048110508134703 1.0052672985228355 0.97467064392997 1.0334702008213594 1.0 16.01371389010839 SALAPNLLTS(ph)GKK ddPTM_A459_Selumetinib_30min_R2 1 SALAPNLLTSGKK 13 1 O15446;O15446-2 O15446 CD3EAP DNA-directed RNA polymerase I subunit RPA34 1 SALAPNLLT(0.181)S(0.819)GKK 118.19 0.0017817 10590000.0 39231.0 46530.0 44278.0 41659.0 39866.0 35968.0 32596.0 36678.0 28950.0 49453.0 True False 37050.69807413604 50098.70138246887 41429.201686241315 35984.972334216625 34857.67667343808 40922.265515004554 34111.778587748646 36784.72690763022 34740.80893058465 48025.1633956752 0.7714851018595922 1.0431760735452364 0.8626561318471668 0.7492941156230855 0.7258210947925086 0.8521004952726453 0.7102896934822404 0.7659469392027678 0.7233876258651764 1.0 15.551502901919779 -5.5793375304474 5.384522953274914 0.7773713436849472 0.9180840231478757 0.17636675645878164 0.10169762512204153 0.23943822964941247 14.385553288157784 0.0257571793412017 0.04602218078134394 2.634283244645972e-06 5.5793375304474 0.14071267946292854 SALEDKERDEDDEDGDGDGDGATGK ddPTM_A459_Selumetinib_30min_R1 2 SALEDKERDEDDEDGDGDGDGATGK 25 2 P50579-3;P50579;G3V1U3;F8VQZ7 P50579-3 METAP2 Methionine aminopeptidase 2 0 ; 94.671 5.2965999999999986e-06 22460000.0 10041.2 12268.3 14150.7 15018.2 11023.5 11497.400000000001 9787.9 10229.0 7022.7 8973.400000000001 False True 10275.140423225977 10831.92173262206 12229.112664231185 12395.553296529059 10026.426371356996 11381.746594803959 9049.590822716505 9957.693691525305 11917.008982285768 10125.223298317851 1.014806303080055 1.0697958369393805 1.207786959746642 1.2242251781833184 0.990242494012229 1.1240983294358418 0.8937670366459922 0.9834542308987517 1.1769625845452312 1.0 13.305666104615696 -6.283479343917973 24.769681360539558 1.0253446784588571 1.130530417973587 0.22243591977842259 0.09247179381905568 1128.606884453473 1268385.0595188471 0.029869037276373193 0.033897238869892314 5.20619770131445e-07 6.283479343917973 0.10518573951472998 SALEDKERDEDDEDGDGDGDGATGK ddPTM_A459_Selumetinib_30min_R2 2 SALEDKERDEDDEDGDGDGDGATGK 25 2 P50579-3;P50579;G3V1U3;F8VQZ7 P50579-3 METAP2 Methionine aminopeptidase 2 0 ; 98.376 3.385e-06 23830600.0 305935.0 298288.0 305981.0 301815.0 288287.0 210993.0 209768.0 212889.0 153715.0 289408.0 False True 288932.3574548393 321165.73045290983 286294.5155869229 260707.27634008418 252069.80974152038 240055.3705462452 219522.62764740636 213508.471744329 184462.2951559526 281052.03906771255 1.0280386451322923 1.1427269181830517 1.01865304566585 0.9276121148413842 0.8968794909927352 0.854131396244415 0.7810746663699452 0.7596759392052993 0.6563279020064713 1.0 18.100477756320664 -6.121271936826039 0.9313888040213842 0.78284616491356 1.0978056344329623 0.6110582651267218 0.08709964020395501 0.36781637350901397 0.6639028694658545 0.03897698629963647 0.07421736662444206 7.563591466259394e-07 6.121271936826039 0.31495946951940235 SALNLNQPVSVSSVS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 SALNLNQPVSVSSVSPVK 18 0 H0YIT6;G3V1N3;Q86XJ1 H0YIT6 GAS2L3 GAS2-like protein 3 1 SALNLNQPVSVSS(0.002)VS(0.998)PVK 207.37 1.7875e-11 5795000.0 72071.0 77064.0 75697.0 62112.0 73526.0 60769.0 49137.0 56480.0 40064.0 74009.0 True False 68065.58234307195 82974.56100018423 70826.73743266199 53652.23845082364 64289.0065492201 69139.37814394222 51421.967863118334 56644.34744923265 48077.919481690624 71872.16787152494 0.9470367230990241 1.1544741651386579 0.9854543076990288 0.7464953408213548 0.8944909893929995 0.9619770794660358 0.7154642664325591 0.7881263238154611 0.6689365425519415 1.0 16.13314558210137 -5.604877611653089 5.291392802704288 0.8210906073627561 1.0554458154619346 0.42736331022147034 0.10960143987893885 0.1744800752521355 8.274515348054546 0.02977808767182921 0.052811332642626815 2.4838329746111955e-06 5.604877611653089 0.23435520809917854 SALPVSPS(ph)ISSAPVPVEIENLPQSPGTDQHDR ddPTM_A459_Selumetinib_30min_R2 1 SALPVSPSISSAPVPVEIENLPQSPGTDQHDR 32 0 Q9HCM4-4;Q9HCM4-3;Q9HCM4;Q9HCM4-2 Q9HCM4-4 EPB41L5 Band 4.1-like protein 5 1 S(0.004)ALPVS(0.112)PS(0.422)IS(0.231)S(0.231)APVPVEIENLPQS(0.001)PGTDQHDR 80.098 5.6603e-06 2315100.0 5398.3 3332.7 2887.7 3527.7 2731.1 2573.5 6633.3 4663.0 4751.5 4192.4 True False 5098.2840971071 3588.3073736805077 2701.9085258900336 3047.221174378069 2387.994801656216 2927.976265092975 6941.761593634593 4676.568557998791 5701.932768002523 4071.354518836643 1.2522329051717889 0.8813546835773559 0.6636387259791079 0.7484539015896823 0.5865357071234776 0.7191651455421821 1.705025087232675 1.148651765981579 1.4005001877438579 1.0 11.991293136279712 -7.238701082976986 24.91765259892124 1.3259319361407487 0.7924602447765383 0.5157774115835808 0.23927678492476148 590.8744771980629 647507.8685942757 0.09156691344895516 0.0708752234808972 5.771635779464062e-08 7.238701082976986 -0.5334716913642104 SALPVSPSISSAPVPVEIENLPQS(ph)PGTDQHDR ddPTM_A459_Selumetinib_30min_R1 1 SALPVSPSISSAPVPVEIENLPQSPGTDQHDR 32 0 Q9HCM4-4;Q9HCM4-3;Q9HCM4;Q9HCM4-2 Q9HCM4-4 EPB41L5 Band 4.1-like protein 5 1 SALPVS(0.002)PS(0.012)IS(0.011)S(0.011)APVPVEIENLPQS(0.872)PGT(0.092)DQHDR 46.028 0.013556 3808900.0 910.08 851.54 677.05 644.11 985.75 1062.1 968.28 978.69 298.64 1024.4 True False 931.2830932925847 751.8413009297936 585.1103287694403 531.6282799421595 896.5890865482975 1051.4162383096425 895.2418600332996 952.7319619668484 506.77026819739183 1155.8917185009927 0.8056836798695213 0.6504426746000153 0.5061982185738255 0.459929136469285 0.77566875183692 0.9096148207317911 0.7745032218020262 0.8242398026714733 0.4384236517020747 1.0 10.174790540200975 -6.373999708473048 9.419647531590037 0.7844974270316548 0.6018370964156905 0.23536541116144893 0.16023789417670628 0.5666942550933513 43.79324052376005 0.05028006787780785 0.057002160001748466 4.226688979886053e-07 6.373999708473048 -0.18266033061596432 SALS(ph)SSLRDLSEAGVHH ddPTM_A459_Selumetinib_30min_R1 1 SALSSSLRDLSEAGVHH 17 1 A0A0C4DGT3 A0A0C4DGT3 IQSEC1 1 S(0.004)ALS(0.4)S(0.298)S(0.298)LRDLSEAGVHH 112.91 0.0010301 18474000.0 4084.0 3966.0 4817.6 6309.8 6239.7 4657.5 4572.7 4169.9 1428.9 2670.4 True False 4179.149253919342 3501.658876256623 4163.396381182565 5207.911879615337 5675.320236708507 4610.649778671648 4227.777557498107 4059.3007062558763 2424.7389372731473 3013.1718518987227 1.3869601401214104 1.1621172134772482 1.3817321367047282 1.7283819627923376 1.8835036684456798 1.5301648911150851 1.4030987163357482 1.3471852605081072 0.8047131250563158 1.0 11.557067241966106 -8.102424507525242 2.9847067884721232 0.9017667275582539 1.5024493688613125 0.5900885842634123 0.19408578963402798 0.21489627499399994 3.4653634751327327 0.18099345229973604 0.0594065353277889 7.899061451511792e-09 8.102424507525242 0.6006826413030586 SALSLSKS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 SALSLSKSPAK 11 1 Q99666;O14715;J3KQ37 Q99666 RGPD5;RGPD8 RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 SALS(0.002)LS(0.123)KS(0.876)PAK 173.06 0.0010054 22399000.0 2263.9 1738.1 2992.7 3247.0 1884.8 2084.8 1896.1 1782.2 1058.2 1102.3 True False 2316.644465217435 1534.6024439792316 2586.307777724398 2679.972403738789 1714.3201727884673 2063.828804846947 1753.0756504411324 1734.9302665985322 1795.6881121299216 1243.79094231125 1.8625674029371655 1.2338105961180155 2.07937498959306 2.154680752666347 1.3783025060488585 1.6593052213516508 1.4094616633752888 1.3948728902741743 1.4437218113143029 1.0 10.280528300808603 -8.094791251089925 0.4915376999731917 1.0175614682057847 1.7847419815338113 0.42740826405971655 0.2665941478030367 0.9368845046841485 0.5759669533564297 0.30245306283443274 0.18016413382349575 8.039124395984642e-09 8.094791251089925 0.7671805133280265 SALSLSKS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 SALSLSKSPAK 11 1 Q99666;O14715;J3KQ37 Q99666 RGPD5;RGPD8 RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 SALSLS(0.006)KS(0.994)PAK 116.71 0.027572000000000003 3700300.0 15170.0 19203.0 18349.0 16027.0 17330.0 10878.0 10601.0 10509.0 7416.7 13004.0 True False 14326.912130321532 20675.808352623033 17168.44531688065 13844.094951882904 15152.850467834294 12376.34575934774 11093.967505482988 10539.579450141393 8900.247239912514 12628.540731550356 1.1344867498845748 1.6372286230164255 1.3594955808304978 1.0962545274368625 1.1998892659052331 0.9800297613506089 0.8784837251834262 0.8345841118293238 0.7047724221751681 1.0 13.624400320259488 -6.504734077808074 0.900091858590384 0.822975485380981 1.4032797722084693 0.6759300370123336 0.146712181397388 0.31850182902238366 0.5646102837177619 0.07953802384489447 0.09748660488656474 3.12799407815112e-07 6.504734077808074 0.5803042868274884 SALSPSKS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 SALSPSKSPAK 11 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 SALSPSKS(1)PAK 130.61 0.011206 80746000.0 3013.2 4048.5 3614.0 3857.4 2959.5 2686.4 3097.1 3527.4 1800.2 2944.6 True False 3083.401697333438 3574.4997379034107 3123.238650281009 3183.7775023658787 2691.8137475421627 2659.3772550560425 2863.483253510484 3433.841893390004 3054.8079185941074 3322.568092832899 0.9280176090249689 1.075824373807102 0.9400074168587056 0.9582279169036731 0.8101605963617918 0.8003981199941625 0.8618283127702618 1.0334902995057147 0.9194116819407325 1.0 11.698083051111828 -5.735499864117439 2.4374020196182213 0.8994600053505974 0.9996890714385637 0.15768900177210954 0.07874628103176841 0.47533008308835883 5.749889618133609 0.024653370442816895 0.04645387332069079 1.8386545291442975e-06 5.735499864117439 0.10022906608796622 SALSS(ph)SLRDLSEAGVHH ddPTM_A459_Selumetinib_30min_R2 2 SALSSSLRDLSEAGVHH 17 1 A0A0C4DGT3 A0A0C4DGT3 IQSEC1 1 S(0.001)ALS(0.08)S(0.459)S(0.459)LRDLSEAGVHH;S(0.002)ALS(0.11)S(0.444)S(0.444)LRDLSEAGVHH 72.815 0.011365 27765000.0 46182.0 50081.0 59335.0 67137.0 67482.0 47637.0 30859.9 29259.0 29368.0 65125.0 True False 43615.38932119371 53922.051664204264 55517.450699063316 57992.82478221513 59004.30786326569 54198.56434436922 32294.946497731777 29344.13884591181 35242.42061048048 63244.67203492902 0.6896294647097803 0.8525943756088098 0.8778202007024706 0.9169598468340009 0.9329530214130695 0.8569664858794148 0.5106350536515676 0.46397803801884707 0.5572393606692538 1.0 15.948656326509727 -7.249538633838048 22.732761467643215 0.588294626319264 0.8618681318430778 0.32240073450245244 0.15168065206259834 206.52283759606743 394499.66052346263 0.05612124017637248 0.04302967891614326 5.629390374050077e-08 7.249538633838048 0.27357350552381376 SALSSS(ph)LR ddPTM_A459_Selumetinib_30min_R1 1 SALSSSLR 8 0 A0A0C4DGT3;A0A3B3IU98;A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2 A0A0C4DGT3;A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 SALS(0.015)S(0.086)S(0.899)LR 96.034 0.021405 8570500.0 5267.3 6895.1 4217.5 4115.6 5235.1 4565.6 6313.2 5678.5 2819.9 5143.5 True False 5390.017841618351 6087.818486554978 3644.7866650692195 3396.8877193801527 4761.586129331976 4519.674209233122 5836.990241213517 5527.88773363246 4785.1643426527735 5803.718326932694 0.9287180283380522 1.048951403844651 0.6280088832284034 0.5852950691312119 0.8204371509960077 0.7787549213508785 1.0057328616598125 0.9524734699786831 0.8244997556905499 1.0 12.502761787147659 -7.249079197257796 24.344972123017694 0.941715977704114 0.7933267579089561 0.2270511346825007 0.13288333742148578 922.6185697718804 1817218.4632478121 0.05637980938318786 0.04332932645029235 5.635348811218521e-08 7.249079197257796 -0.14838921979515785 SALSSS(ph)LR ddPTM_A459_Selumetinib_30min_R2 3 SALSSSLR 8 0 A0A0C4DGT3;A0A3B3IU98;A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2 A0A0C4DGT3;A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 SALS(0.012)S(0.082)S(0.906)LR;SALS(0.002)S(0.015)S(0.983)LR;SALS(0.022)S(0.078)S(0.9)LR 114.89 0.01011 77464000.0 771360.0 533570.0 715680.0 825420.0 870760.0 681080.0 791530.0 838840.0 708950.0 681530.0 True False 728490.8991987358 574493.1033020392 669633.927973466 712996.3720710779 761367.3441068324 774892.587771333 828337.7133869395 841280.8855225627 850759.8097180646 661852.4580724027 1.1006847376837017 0.8680078109480905 1.0117571065970294 1.077273889935573 1.1503581120243318 1.1707935481997778 1.2515443635269 1.271100341566657 1.2854221501206489 1.0 19.336150117857606 -6.198458541696707 1.3548060751263549 1.2188589580216105 0.9763626730448379 0.4725232422948067 0.09266764768819223 0.3227616407305514 1.1964013869040173 0.0339764307386947 0.05076437043308066 6.332008049795072e-07 6.198458541696707 -0.24249628497677256 SALSSS(ph)LRDLSEAGK ddPTM_A459_Selumetinib_30min_R2 1 SALSSSLRDLSEAGK 15 1 A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2 A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 SALS(0.039)S(0.173)S(0.788)LRDLSEAGK 105.0 0.022972 2633900.0 21999.0 23436.0 25057.0 25536.0 25988.0 16437.0 16813.0 14452.0 15195.0 24468.0 True False 20776.3836489745 25233.465841382782 23444.85989999883 22057.952747942938 22723.15510433223 18701.047549770068 17594.83781432748 14494.052927342598 18234.424583773194 23761.545264501245 0.8743700553858149 1.061945490518267 0.9866723581746374 0.9283046410662776 0.9562995525497103 0.7870299402500834 0.7404753191962407 0.6099793917441938 0.7673922036970661 1.0 14.536341040306885 -6.798679191597127 3.2608611540180243 0.7480468348039225 0.9696568841023505 0.4295658154821148 0.10133187695617715 0.1975028004516931 4.320930061347951 0.03595192660156513 0.03274126824072482 1.5897206235555385e-07 6.798679191597127 0.22161004929842798 SALVTSSSS(ph)LPSFPSTLSWSR ddPTM_A459_Selumetinib_30min_R1 2 SALVTSSSSLPSFPSTLSWSR 21 0 F8VXI9;Q14161-6;Q14161-4;Q14161-3;Q14161 F8VXI9 GIT2 ARF GTPase-activating protein GIT2 1 SALVTSSS(0.002)S(0.998)LPSFPSTLSWSR;SALVTSSS(0.002)S(0.998)LPSFPSTLSWSR 319.45 2.8071999999999983e-136 38148000.0 5883.9 5977.8 7091.9 7162.9 6738.9 5413.1 5489.2 5798.1 3066.4 5002.5 True False 6020.983421923612 5277.9163969961755 6128.858933018235 5912.0339792856685 6129.367684849425 5358.649128701558 5075.145224619725 5644.315553116904 5203.456839005098 5644.619603476388 1.0666765601379817 0.935034912493595 1.085787770223456 1.0473750924942022 1.0858779006249584 0.9493375116724061 0.8991120006552901 0.9999461344818884 0.9218436678709778 1.0 12.462660644283972 -6.7800768590333975 24.940823422904117 0.950610968679026 1.0405808001066101 0.4534313236841174 0.04931241713559985 223.17391391424442 298651.10181704274 0.01717669731962168 0.015174172494700601 1.6592932289207867e-07 6.7800768590333975 0.08996983142758419 SALVTSSSS(ph)LPSFPSTLSWSR ddPTM_A459_Selumetinib_30min_R2 2 SALVTSSSSLPSFPSTLSWSR 21 0 F8VXI9;Q14161-6;Q14161-4;Q14161-3;Q14161 F8VXI9 GIT2 ARF GTPase-activating protein GIT2 1 SALVTSSS(0.041)S(0.959)LPSFPSTLSWSR;SALVTS(0.001)S(0.001)S(0.208)S(0.791)LPSFPSTLSWSR 239.93 4.6879e-31 9314300.0 18345.9 18227.0 21003.0 21091.8 23048.8 16610.4 17093.5 17871.1 15610.5 20780.6 True False 17326.308322456538 19624.95229095765 19651.68984633737 18219.06045461557 20153.203685113636 18898.331825801593 17888.38162012767 17923.10194228013 18733.03619381318 20180.610083517036 0.8585621668895028 0.9724657584552793 0.9737906715906635 0.9028002810230398 0.9986419440101176 0.9364598863756467 0.8864143128526331 0.8881347921646443 0.92826907196001 1.0 14.300682169016525 -7.0152820251264245 24.7906688896423 0.9156759630374196 0.9451470475426049 0.002782652942047381 0.04754214253855988 1744.7885438330152 2830411.1900177933 0.017167737902071715 0.013751847248647732 9.65423741900007e-08 7.0152820251264245 0.02947108450518532 SAMDSPVPAS(ph)MFAPEPSSPGAAR ddPTM_A459_Selumetinib_30min_R2 2 SAMDSPVPASMFAPEPSSPGAAR 23 0 F8WAZ4;O00178 F8WAZ4 GTPBP1 GTP-binding protein 1 1 SAMDSPVPAS(0.506)MFAPEPS(0.247)S(0.247)PGAAR;SAMDSPVPAS(0.93)MFAPEPS(0.035)S(0.035)PGAAR 164.92 8.427399999999999e-11 29346000.0 87032.0 69817.0 84692.0 85432.0 91870.0 64549.0 67386.0 67977.0 61184.0 82359.0 True False 82195.10985670028 75171.73940296222 79243.00892567763 73796.01422157988 80328.4692717794 73440.03883251856 70519.5825228258 68174.80181580178 73422.50962379597 79981.08167561957 1.0276818984526888 0.939869001870184 0.9907719083753411 0.9226683695136239 1.004343372068519 0.9182176246424172 0.8817032858949457 0.8523865942736222 0.9179984577049946 1.0 16.287371172044075 -6.912468991385718 5.9739395135121764 0.9006113798719428 0.972470871010317 0.30639318474782906 0.045638769741717794 0.22316614564238849 12.173151909300813 0.015401280697951072 0.013553961972243714 1.2232944591232075e-07 6.912468991385718 0.0718594911383742 SAMDSPVPASMFAPEPS(ph)SPGAAR ddPTM_A459_Selumetinib_30min_R1 2 SAMDSPVPASMFAPEPSSPGAAR 23 0 F8WAZ4;O00178 F8WAZ4 GTPBP1 GTP-binding protein 1 1 SAMDSPVPASMFAPEPS(0.648)S(0.352)PGAAR;SAMDSPVPASMFAPEPS(0.5)S(0.5)PGAAR 165.01 6.5783e-13 5676800.0 3092.9 3625.8 3516.5 4072.9 4123.4 3276.3 3853.4 3218.5 1865.1999999999998 2674.2 True False 3164.958552264236 3201.289650411311 3038.978614751844 3361.64447280188 3750.4391980453956 3243.3433966423872 3562.7349356098616 3133.134924838612 3165.1081711819415 3017.459618913857 1.0488818251040826 1.0609221181768869 1.0071314942221936 1.114064444054404 1.2429128047106648 1.074858923152661 1.1807067485768967 1.0383353285656869 1.0489314095017555 1.0 11.559118748937317 -5.777767625173167 24.742014948453487 1.1098434650591882 1.041172845365791 0.13280302118634413 0.06816769596855923 368.73877363301415 558744.9172136475 0.01947861226851559 0.028990987147472322 1.6681395332358484e-06 5.777767625173167 -0.06867061969339727 SAMDSPVPASMFAPEPS(ph)SPGAAR ddPTM_A459_Selumetinib_30min_R2 1 SAMDSPVPASMFAPEPSSPGAAR 23 0 F8WAZ4;O00178 F8WAZ4 GTPBP1 GTP-binding protein 1 1 SAMDSPVPASMFAPEPS(0.5)S(0.5)PGAAR 174.04 5.627199999999998e-13 5178900.0 21140.0 22003.0 30363.0 27757.0 28746.0 18076.0 19038.0 26105.0 21961.0 26711.0 True False 19965.12343012506 23690.559349203995 28409.477636734806 23976.448716504245 25134.670487499403 20565.80492240943 19923.304723081317 26180.961228084598 26353.81364160862 25939.78402648736 0.7696719220845664 0.913290539543943 1.0952087190751325 0.9243118096905382 0.9689622111669917 0.7928286874481874 0.7680597765477709 1.0092975793996963 1.015961182047564 1.0 14.662878847372957 -7.9108491229598705 24.988041319342237 1.0096340081875135 0.8988902466386837 0.2432312629765372 0.09460477547462151 32.1721658410844 9007.1888969527 0.0562595809366782 0.027026228024717533 1.2278657264931815e-08 7.9108491229598705 -0.11074376154882981 SAMDSPVPASMFAPEPSS(ph)PGAAR ddPTM_A459_Selumetinib_30min_R1 3 SAMDSPVPASMFAPEPSSPGAAR 23 0 F8WAZ4;O00178 F8WAZ4 GTPBP1 GTP-binding protein 1 1 SAMDSPVPASMFAPEPS(0.08)S(0.92)PGAAR;SAMDSPVPAS(0.001)MFAPEPS(0.356)S(0.643)PGAAR;SAMDSPVPASMFAPEPS(0.03)S(0.97)PGAAR 286.67 1.7383e-80 26421700.0 12666.2 17639.6 18147.7 18685.6 17218.6 16143.2 16296.1 14023.5 7912.0 13037.400000000001 True False 12961.29781586512 15574.34743157244 15683.342018180598 15422.510732153216 15661.180670190732 15980.814064852846 15066.872056934622 13651.551225252224 13426.08613038361 14710.877285030108 0.8810689916538579 1.0586960335411815 1.0661051488846336 1.0483746436962853 1.0645986888985648 1.0863263798084315 1.024199425024555 0.9279902864218803 0.9126638656721098 1.0 13.844595664009146 -7.702480900811372 5.446375721914503 0.940226303472172 1.0397948554412548 0.31028197257988366 0.05803552649592523 0.2095252758118214 12.437333641835371 0.028601877174409093 0.015832231844739825 1.9838969017580162e-08 7.702480900811372 0.09956855196908287 SAMDSPVPASMFAPEPSS(ph)PGAAR ddPTM_A459_Selumetinib_30min_R2 2 SAMDSPVPASMFAPEPSSPGAAR 23 0 F8WAZ4;O00178 F8WAZ4 GTPBP1 GTP-binding protein 1 1 SAMDSPVPASMFAPEPS(0.025)S(0.975)PGAAR;SAMDSPVPASMFAPEPS(0.047)S(0.953)PGAAR 299.53 2.3081999999999994e-107 7276100.0 28982.0 27292.0 26994.0 30732.0 30396.0 22621.0 21565.0 25936.0 21342.9 27538.0 True False 27371.296464138333 29385.20864238857 25257.235428844957 26546.248584342986 26577.38273631225 25736.837417007268 22567.815230236833 26011.469466064045 25612.07637045167 26742.906387683313 1.023497448906467 1.098803855362639 0.9444461668712794 0.9926463563649573 0.9938105586217325 0.9623799688750584 0.8438804258250197 0.9726493107736361 0.9577147673914583 1.0 14.706868643905267 -5.27027403597119 24.92406337862125 0.9559981858336106 1.061150652922616 0.45002447667569867 0.04535342183151384 487.05142447651855 1374056.1558019652 0.012312475570897551 0.02624850283058235 5.36693040950734e-06 5.27027403597119 0.10515246708900539 SAMPFT(ph)ASPASSTTAR ddPTM_A459_Selumetinib_30min_R2 3 SAMPFTASPASSTTAR 16 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 SAMPFT(0.441)AS(0.309)PAS(0.069)S(0.139)T(0.031)T(0.01)AR;SAMPFT(0.819)AS(0.165)PAS(0.01)S(0.005)T(0.001)TAR;SAMPFT(0.494)AS(0.494)PAS(0.003)S(0.004)T(0.002)T(0.002)AR 142.57 0.00092148 281211000.0 176365.0 183919.0 186531.0 237534.0 236413.0 162489.0 173477.0 155619.0 131427.0 208049.0 True False 166563.33934503348 198024.99590720632 174529.79853959734 205181.45943099502 206712.68538096396 184870.3848217185 181544.0242381541 156071.82552588775 157716.0723772004 202042.0847937803 0.8243992310564447 0.980117563671578 0.8638289330548925 1.0155382213582829 1.0231169688827495 0.9150092913088451 0.8985455897638945 0.7724718624101838 0.780610002803018 1.0 17.624296308005015 -7.481472111242684 3.3659190628970683 0.8323702143721127 0.9425581204755946 0.159831261116679 0.08307923275611932 0.34264304152398184 7.881331980148639 0.03951285276786817 0.02358621856208611 3.300105992692215e-08 7.481472111242684 0.11018790610348195 SAMPFTAS(ph)PASSTTAR ddPTM_A459_Selumetinib_30min_R1 5 SAMPFTASPASSTTAR 16 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 SAMPFT(0.002)AS(0.998)PASSTTAR;SAMPFT(0.001)AS(0.926)PAS(0.072)S(0.001)TTAR;SAMPFT(0.036)AS(0.914)PAS(0.049)S(0.001)TTAR;SAMPFT(0.106)AS(0.755)PAS(0.009)S(0.099)T(0.03)T(0.001)AR;S(0.001)AMPFT(0.113)AS(0.52)PAS(0.024)S(0.182)T(0.153)T(0.008)AR 287.43 1.8215999999999997e-74 204005000.0 11026.3 13192.13 14207.7 15404.599999999999 13714.699999999999 10461.11 13186.300000000001 11340.699999999999 6764.93 9338.240000000002 True False 11283.191336555055 11647.589286745148 12278.372377309763 12714.475790155388 12474.207806526943 10355.880731327914 12191.646774648967 11039.907796214773 11479.592119061681 10536.8940661604 1.070827064000901 1.1054101155056484 1.16527434936849 1.2066625810530227 1.1838600377115203 0.9828209969943784 1.1570436884055675 1.0477383303747752 1.0894664069869306 1.0 13.363162049589384 -6.73964662853433 24.99998791243638 1.0647493481606136 1.1485249736894934 0.37926416528748264 0.05755715287595372 288.0994985100879 330498.37833436107 0.019373613844923428 0.019356465199690382 1.8211820932648843e-07 6.73964662853433 0.08377562552887974 SAMPFTAS(ph)PASSTTAR ddPTM_A459_Selumetinib_30min_R2 3 SAMPFTASPASSTTAR 16 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 SAMPFT(0.014)AS(0.879)PAS(0.102)S(0.004)T(0.001)TAR;SAMPFT(0.038)AS(0.584)PAS(0.026)S(0.266)T(0.082)T(0.004)AR;S(0.001)AMPFT(0.16)AS(0.757)PAS(0.005)S(0.061)T(0.016)TAR 183.76 8.5417e-07 35464800.0 72716.0 82031.0 82783.0 92473.0 84997.0 66070.0 66996.0 71176.0 61338.0 83027.0 True False 68674.73582521152 88322.51392876232 77456.8319073156 79878.01787517715 74318.91697717895 75170.5427762552 70111.44675005546 71383.11037617894 73607.31392691549 80629.79477994713 0.8517290167069994 1.095407896917138 0.9606477620178607 0.9906761897779635 0.9217302013481284 0.9322923738229623 0.8695476274174071 0.8853192615830908 0.9129046418610239 1.0 16.29902542969606 -6.357931368560209 3.1114145319057944 0.910517484669764 0.9827358356679419 0.13164451166557 0.06427619938356258 0.4081916819056198 7.597734964545642 0.02003094407370421 0.023391708235706764 4.3860000413891683e-07 6.357931368560209 0.07221835099817786 SAMPFTASPAS(ph)STTAR ddPTM_A459_Selumetinib_30min_R1 1 SAMPFTASPASSTTAR 16 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 SAMPFTAS(0.09)PAS(0.888)S(0.016)T(0.005)T(0.001)AR 207.66 6.935e-08 69551000.0 1480.8 1707.5 1652.0 1743.9 1692.0 1297.7 1517.3 1566.8 814.19 1342.4 True False 1515.2997588647802 1507.5851062047866 1427.66747378645 1439.3606020573066 1538.9588987468626 1284.646316217326 1402.8488394147616 1525.243374316339 1381.6209639151973 1514.7101160832992 1.0003892776414576 0.9952961231308494 0.9425351152193253 0.9502548288111856 1.0160088603133286 0.848113644041101 0.9261500431793604 1.0069539762897184 0.9121355626037273 1.0 10.56482600304333 -5.253866567751557 19.567028673722515 0.9483549050439708 0.9978429116981614 0.13723326968941374 0.04752029241172224 56.986568864351874 147218.36992488403 0.012129101135955939 0.03035396552065856 5.573569644841227e-06 5.253866567751557 0.04948800665419062 SAMPFTASPASS(ph)TTAR ddPTM_A459_Selumetinib_30min_R2 1 SAMPFTASPASSTTAR 16 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 SAMPFT(0.002)AS(0.002)PAS(0.036)S(0.725)T(0.224)T(0.01)AR 135.57 0.0015633 22252000.0 56064.0 69421.0 80766.0 80473.0 77813.0 54043.0 51888.0 64458.0 54435.0 86498.0 True False 52948.18732197404 74745.36747630288 75569.60349137188 69512.43857633199 68037.4352829539 61486.93269649106 54300.89481412141 64645.56210840366 65323.521040980166 84000.57799120586 0.6303312261436731 0.8898196805756274 0.8996319465716458 0.8275233366085807 0.8099638944160221 0.7319822573474222 0.6464347759584017 0.7695847297047348 0.7776556138437402 1.0 16.358111634371532 -3.680899912383361 16.09139160745081 0.7923243782899589 0.15559219171018623 0.0 0.10844285336783528 0.0 0.0 0.024676247949535907 0.0 0.00020849713307557246 3.680899912383361 -0.6367321865797727 SANAFLTPSYTWT(ph)PLKTEVDESQATK ddPTM_A459_Selumetinib_30min_R1 1 SANAFLTPSYTWTPLKTEVDESQATK 26 1 Q15398-1;Q15398;Q15398-3 Q15398-1 DLGAP5 Disks large-associated protein 5 1 SANAFLT(0.003)PS(0.135)Y(0.121)T(0.107)WT(0.633)PLKTEVDESQATK 89.039 7.6604e-05 10867000.0 1192.0 1446.1 1736.6 2321.8 1397.7 1639.9 1818.7 1668.7 859.87 1164.0 True False 1219.7712807717576 1276.789939726349 1500.7792584609845 1916.341215583836 1271.278281783978 1623.4040949100674 1681.5139947562297 1624.4406552984906 1459.1365875799997 1313.410738320143 0.9287051226121764 0.9721177865192178 1.1426579779456398 1.4590570639271938 0.9679213399838251 1.236021640105065 1.2802651491237935 1.2368108527696033 1.110952229190878 1.0 10.359102440399152 -5.2865250865500695 4.014350303473905 1.1980354063936103 0.9435966950624368 0.31809366231322955 0.13379796244329195 0.21869453500324354 8.121510314747312 0.03424266168659788 0.08501627300902809 5.169813942361939e-06 5.2865250865500695 -0.25443871133117346 SANGGSES(ph)DGEENIGWSTVNLDEEK ddPTM_A459_Selumetinib_30min_R1 1 SANGGSESDGEENIGWSTVNLDEEK 25 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 S(0.076)ANGGS(0.176)ES(0.742)DGEENIGWS(0.004)T(0.002)VNLDEEK 89.805 3.5889e-05 6197200.0 517.23 712.51 656.63 676.79 699.21 666.73 753.81 709.89 339.99 651.0 True False 529.2804526456171 629.0889979630873 567.4632526104091 558.6013314217349 635.9665789555517 660.0233015424046 696.9495048040876 691.0614111523021 576.9381981128823 734.5621912769873 0.7205386540865905 0.8564135282670323 0.772519004311823 0.7604547825292285 0.8657763583638388 0.8985261008261237 0.9487957766958949 0.9407799902564247 0.7854177698826478 1.0 9.520740830656504 -6.479319745518467 2.898247871885044 0.9128714311815552 0.7829040238651602 0.534284880611949 0.06021555759119316 0.2234449746033946 3.7449698495920103 0.020005304170500303 0.02192870874584782 3.316501930873664e-07 6.479319745518467 -0.129967407316395 SANPTRPSS(ph)PVTSHISK ddPTM_A459_Selumetinib_30min_R1 1 SANPTRPSSPVTSHISK 17 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 SANPT(0.006)RPS(0.132)S(0.59)PVT(0.221)S(0.051)HISK 64.87 0.024605 23984000.0 2261.7 2601.2 2396.1 2460.0 4127.0 2426.3 3242.7 2133.4 635.8 1257.1 True False 2314.393209497888 2296.6502947349286 2070.7227808351754 2030.4071799191304 3753.713578681029 2401.893624904137 2998.1005282872507 2076.815301740159 1078.9061630052956 1418.4610301909383 1.6316226954690105 1.619114128518411 1.4598376245531655 1.4314155529854904 2.6463283084877864 1.6933095614060116 2.113629112449905 1.4641327872508418 0.7606174156649651 1.0 10.47011080022144 -8.083330887765573 4.061284074227645 0.8984113650786153 1.7947207108677958 0.5282666359204231 0.34317646820455694 0.19229946554249377 5.6808947197392445 0.2629369630259724 0.09324428686287932 8.254088332376154e-09 8.083330887765573 0.8963093457891805 SANPTRPSS(ph)PVTSHISK ddPTM_A459_Selumetinib_30min_R2 1 SANPTRPSSPVTSHISK 17 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 SANPTRPS(0.003)S(0.991)PVT(0.005)S(0.001)HISK 107.06 0.0013667999999999998 13086000.0 10015.0 9602.4 16559.0 22212.0 24083.0 12745.0 10651.0 11024.0 16151.0 18742.0 True False 9458.4063932215 10338.873203417561 15493.611968076006 19186.687282162773 21057.47823524833 14500.508062409172 11146.292604556103 11056.078014878556 19381.651296645014 18200.869762435934 0.5196678244872855 0.5680428099516188 0.851256680054525 1.0541632093737316 1.1569490090362626 0.7966931389364812 0.6124043933087474 0.6074477845941607 1.0648750059541687 1.0 14.151719773488315 -5.256566970749615 4.350415233933574 0.8824133005565271 0.534029263416281 0.38845008494277866 0.17558109350243817 0.22903455156319208 11.284058867653876 0.05148267312676721 0.13274164847942882 5.539021224050602e-06 5.256566970749615 -0.34838403714024613 SANPTRPSSPVTSHIS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 SANPTRPSSPVTSHISK 17 1 Q92560;F8W6N3;H0Y8E8 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 SANPTRPS(0.022)S(0.209)PVT(0.097)S(0.143)HIS(0.529)K 80.733 0.0089404 20412000.0 2179.3 2298.5 1828.7 2568.9 3839.4 2508.1 3697.6 2376.5 699.59 1322.5 True False 2230.073449820377 2029.3905514563405 1580.3725843300729 2120.289839225308 3492.126947901124 2482.8707911725946 3418.6870550451604 2313.4675000400703 1187.153133968033 1492.2557572408848 1.4944311248252007 1.3599482137087509 1.0590494133874961 1.4208622274948568 2.3401665103024385 1.6638373007609053 2.290952498227356 1.5503156806830283 0.7955426730355035 1.0 10.543279104492257 -6.0138446039070494 24.729620437996935 1.6903899096040547 1.2983454381087647 0.06328770588799071 0.4669162424229582 1215.6166349902894 2171373.7720057103 0.13804819318878228 0.186204850634798 9.686243803933001e-07 6.0138446039070494 -0.39204447149529 SANT(ph)SPESSSR ddPTM_A459_Selumetinib_30min_R2 1 SANTSPESSSR 11 0 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 S(0.455)ANT(0.512)S(0.034)PESSSR 103.97 0.029835000000000007 14450000.0 33703.0 22821.0 36083.0 33459.0 37796.0 36294.0 62966.0 131310.0 45530.0 81199.0 True False 31829.92218379872 24571.297318919434 33761.45906419993 28901.826480005595 33047.72857947289 41293.16905587121 65894.04376476207 131692.09036045923 54637.272214491146 78854.57388966157 0.40365346756343157 0.311602689696874 0.4281483926530521 0.3665206094505932 0.4190971677269528 0.5236623193684528 0.8356400968822086 1.6700627986999377 0.6928865317431449 1.0 16.266906819239324 -7.351468107171996 2.9771117536576037 1.1491936138177432 0.395657033906916 0.65439772817697 0.2330181447494483 0.14584915155440145 2.5061325527295435 0.1016822531883207 0.06482744838931358 4.451761536536705e-08 7.351468107171996 -0.7535365799108272 SANTS(ph)PESSSR ddPTM_A459_Selumetinib_30min_R1 1 SANTSPESSSR 11 0 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 SANT(0.088)S(0.91)PES(0.001)SSR 104.9 0.012001 996380.0 806.69 889.27 745.41 743.92 772.95 1006.5 827.21 1083.7 857.45 1039.7 True False 825.4843074545038 785.1538549895932 644.1874162440415 614.0083371079024 703.036808975406 996.3755238288808 764.8128837094087 1054.9567556462962 1455.0300243298072 1173.1556225356135 0.7036443346453335 0.669266583143157 0.5491065327306872 0.5233818304350862 0.5992698628131613 0.8493123202830951 0.6519279019916995 0.8992470695116759 1.2402702560338597 1.0 10.196178688453383 -7.940780383262251 2.8451804693798284 1.1189355268649144 0.6449481453798613 0.7756266452120919 0.10206500831386535 0.12589924157081275 1.9946601891240148 0.07621620221170516 0.02927984930048761 1.1460923580514668e-08 7.940780383262251 -0.47398738148505304 SANTS(ph)PESSSR ddPTM_A459_Selumetinib_30min_R2 1 SANTSPESSSR 11 0 P20749;H7C0A2 P20749 BCL3 B-cell lymphoma 3 protein 1 SANT(0.085)S(0.914)PES(0.001)SSR 111.72 0.008086399999999999 17002000.0 28887.0 17925.0 24130.0 30377.0 28668.0 25243.0 49538.0 108600.0 41457.0 65988.0 True False 27281.576183823192 19299.789862040707 22577.502070757546 26239.600196752148 25066.469544828265 28719.99411686107 51841.61515768476 108916.00802030209 49749.55840536261 64082.754982585706 0.4257241467105601 0.3011697900205034 0.35231790638359595 0.4094642966564512 0.3911578013716795 0.4481704028590163 0.8089791890466096 1.699614943987656 0.7763330153156165 1.0 15.96764855155133 -7.430819917209112 3.502010703325484 1.1904928320576507 0.3842613190970933 0.703078613366275 0.22403077590162954 0.11913882472367623 2.739438544774752 0.09700164321316096 0.060477849541913514 3.7083445862108534e-08 7.430819917209112 -0.8062315129605573 down SAPAMQSS(ph)GSFNYARPK ddPTM_A459_Selumetinib_30min_R2 1 SAPAMQSSGSFNYARPK 17 1 Q8WX93;Q8WX93-3;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 SAPAMQS(0.155)S(0.455)GS(0.39)FNYARPK 77.959 0.010623 13526000.0 23593.0 27899.0 29520.0 32147.0 33434.0 15993.0 22126.0 28059.0 21711.0 22126.0 True False 22281.795510262076 30038.763590575953 27620.715338945804 27768.52314333184 29233.72201624766 18195.890580000763 23154.902841837233 28140.647044582474 26053.806656025 21487.164889748015 1.0369816411141888 1.397986367429427 1.2854518258071466 1.292330713978036 1.3605202066558204 0.8468260318829876 1.0776155421455778 1.3096491411954017 1.2125288184694774 1.0 14.391187519396187 SAPAMQSSGS(ph)FNYARPK ddPTM_A459_Selumetinib_30min_R2 1 SAPAMQSSGSFNYARPK 17 1 Q8WX93;Q8WX93-3;Q8WX93-4;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 SAPAMQS(0.002)S(0.056)GS(0.942)FNYARPK 68.676 0.019811 21384000.0 40813.0 35349.0 38123.0 32021.0 39756.0 23446.0 26980.0 37896.0 23336.0 31908.0 True False 38544.77684738383 38060.15463505031 35670.207685183974 27659.68456069397 34761.49585685056 26675.473678402916 28234.62345985578 38006.27108597948 28003.852062318594 30986.73313305975 1.2439122472791557 1.2282725794815694 1.1511445085873677 0.892629902026808 1.1218186734168345 0.8608675707715328 0.9111842587152968 1.226533656283714 0.9037368328590044 1.0 14.919363042147957 -5.576881284281208 5.326076427786121 0.9949780907882907 1.2264423831572635 0.48001036509384976 0.10682885372095664 0.16263646599678974 9.784505969742158 0.02888225843410605 0.05174139796673062 2.649224213142151e-06 5.576881284281208 0.2314642923689728 SAPAS(ph)PTHPGLMSPR ddPTM_A459_Selumetinib_30min_R1 4 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 SAPAS(0.85)PT(0.149)HPGLMS(0.001)PR;SAPAS(1)PTHPGLMSPR;SAPAS(0.996)PT(0.003)HPGLMSPR;SAPAS(0.499)PT(0.499)HPGLMS(0.002)PR 219.95 2.2682e-09 101287100.0 4900.43 5648.8 6089.63 6598.16 6456.59 5167.79 6086.28 5312.9400000000005 2248.97 3972.8799999999997 True False 5014.600484423108 4987.435869944129 5262.691693943205 5445.91521880293 5872.592574503547 5115.806724577895 5627.18699950786 5172.0235723386895 3816.337831730138 4482.837847128294 1.1186218764605687 1.1125621849425316 1.173964322023043 1.2148365398252323 1.3100167293058638 1.1411982541048369 1.2552733762414885 1.153738713893452 0.8513218550108574 1.0 12.13019659993853 -8.17624307819622 5.648581030459298 0.9277625804181603 1.1901425139821182 0.7076290736087919 0.0668418982264364 0.11240062501104006 5.6492925034831085 0.04837637505541983 0.017521111457279942 6.664336564032699e-09 8.17624307819622 0.26237993356395795 SAPAS(ph)PTHPGLMSPR ddPTM_A459_Selumetinib_30min_R2 4 SAPASPTHPGLMSPR 15 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 S(0.003)APAS(0.992)PT(0.004)HPGLMSPR;S(0.114)APAS(0.876)PT(0.01)HPGLMSPR;S(0.311)APAS(0.686)PT(0.003)HPGLMSPR;SAPAS(0.5)PT(0.5)HPGLMS(0.001)PR 183.28 2.0847e-05 100241000.0 67226.9 78624.9 99251.0 106094.3 126522.0 83557.1 79366.90000000001 82907.0 80168.7 99398.8 True False 63490.69802860338 84655.17701110002 92865.29871631801 91644.07331712419 110627.17523896901 95066.33206916662 83057.61811252889 83148.24564400718 96204.68010063417 96528.89837490229 0.6577377251526895 0.8769930915642827 0.9620466024137615 0.9493952055807552 1.14605239572207 0.9848484098507443 0.8604430332349472 0.8613818974818622 0.9966412309709688 1.0 16.558673293959473 -4.719143466210991 1.9391376734945482 0.9680594985759502 0.5283415895520843 0.6107524782012079 0.07562092948507435 0.717507547733672 2.5399845361078786 0.022558144957889457 0.6035816984404777 1.9092224558044312e-05 4.719143466210991 -0.43971790902386587 SAPAS(ph)PVQSPAK ddPTM_A459_Selumetinib_30min_R1 3 SAPASPVQSPAK 12 0 P35612 P35612 ADD2 Beta-adducin 1 SAPAS(0.989)PVQS(0.011)PAK;SAPAS(0.954)PVQS(0.046)PAK;SAPAS(0.991)PVQS(0.009)PAK 177.93 0.00010371 27289700.0 8653.8 7664.2 9871.1 11003.099999999999 9963.2 7457.299999999999 7090.8 6909.3 3945.5600000000004 6678.299999999999 True False 8855.416702636438 6766.871901010083 8530.658838071073 9081.61513876756 9062.030319145833 7382.286332686648 6555.935247164172 6726.042919430618 6695.327147699244 7535.524857150701 1.1751559274910026 0.897996095731644 1.1320590137760687 1.2051735361405815 1.202574537398889 0.9796645187470068 0.8700037982016655 0.8925778956256857 0.8885017665817708 1.0 12.879492285196227 -6.953376081825573 5.558991695360582 0.9061271290807204 1.1145765083901609 0.5615594278448345 0.08809341948956909 0.15259457072465896 10.925270312288337 0.03357930718734838 0.02921808282086555 1.1133300163229404e-07 6.953376081825573 0.20844937930944052 SAPAS(ph)PVQSPAK ddPTM_A459_Selumetinib_30min_R2 4 SAPASPVQSPAK 12 0 P35612 P35612 ADD2 Beta-adducin 1 SAPAS(0.519)PVQS(0.481)PAK;SAPAS(0.992)PVQS(0.008)PAK;S(0.001)APAS(0.877)PVQS(0.123)PAK;SAPAS(1)PVQSPAK 198.81 0.00010536 82282000.0 138350.0 128220.0 135314.0 145653.0 142129.0 82255.0 100209.0 106796.0 102049.0 109191.0 True False 130661.06085893107 138054.06170771894 126608.044558744 125814.81013456013 124273.4843706185 93584.8796134536 104868.91706036657 107106.75867897033 122461.65148729678 106038.372117711 1.2322054577930237 1.3019255100829725 1.1939832914277393 1.1865026558017668 1.1719671085922092 0.8825567362498451 0.9889713974857494 1.010075471170694 1.1548805309021024 1.0 16.694226901926136 -6.595103586949145 6.520187492753695 1.007177072657465 1.2252767783837315 0.7088885085648725 0.06802144050289553 0.12333649971671601 8.812618796287158 0.02381222845201203 0.023823623407341392 2.5403667106919704e-07 6.595103586949145 0.21809970572626658 SAPGST(ph)PVRR ddPTM_A459_Selumetinib_30min_R2 1 SAPGSTPVRR 10 1 F5H1D6;Q07864;A0A087WW42;A0A087WX51 F5H1D6 POLE DNA polymerase;DNA polymerase epsilon catalytic subunit A 1 SAPGS(0.026)T(0.974)PVRR 98.898 0.0238 4161900.0 10845.0 8015.2 7253.0 10222.0 11028.0 8380.9 7332.9 7699.7 6641.5 11478.0 True False 10242.27831597475 8629.940067069943 6786.349876469308 8829.745966066452 9642.564048429122 9535.292900764616 7673.894379865692 7722.104852246047 7969.985579014781 11146.600316574515 0.9188701509952701 0.774221719804342 0.6088268784858373 0.7921469968683634 0.8650677134346554 0.8554440484051488 0.6884515602891889 0.6927766882215746 0.7150149240718495 1.0 13.4443161386364 -4.766400784876543 6.231604640708373 0.7645965372559175 0.9234690384896098 0.13061160766467061 0.1059335835735954 0.23236201928618203 38.1754498097457 0.026292191597759453 0.1570075765381329 1.712376326558529e-05 4.766400784876543 0.15887250123369234 SAPS(ph)PTSNSTYLTMNAASR ddPTM_A459_Selumetinib_30min_R2 2 SAPSPTSNSTYLTMNAASR 19 0 Q96JM2;Q96JM2-3 Q96JM2 ZNF462 Zinc finger protein 462 1 SAPS(0.844)PT(0.155)S(0.001)NSTYLTMNAASR;SAPS(0.776)PT(0.109)S(0.109)NS(0.003)T(0.003)Y(0.001)LTMNAASR 193.72 3.2048000000000003e-15 6291700.0 16765.1 13835.6 15248.7 14413.0 13282.8 12233.1 12728.8 12933.6 11249.8 14091.5 True False 15833.362858012742 14896.746031534196 14267.615243529244 12449.92453618819 11614.09591426136 13918.098483974709 13320.714421638693 12971.234634727261 13500.074345674997 13684.641780886037 1.1570169765150828 1.0885740576959173 1.0426005643390295 0.9097735063534923 0.8486956472973444 1.0170597598992144 0.9734061464615276 0.947868043783563 0.9865128047802586 1.0 13.740270049714264 -5.389255565358233 2.2967765121070287 0.952367546135186 1.134122671698088 0.6599699801663765 0.048495563897237366 0.19345895212282885 1.9425296764894597 0.014321308077833717 0.0410175128073677 4.080791769886077e-06 5.389255565358233 0.18175512556290185 SAPS(ph)SPAPR ddPTM_A459_Selumetinib_30min_R1 2 SAPSSPAPR 9 0 E9PAK5;O75064 E9PAK5 DENND4B DENN domain-containing protein 4B 1 S(0.001)APS(0.499)S(0.499)PAPR;SAPS(0.5)S(0.5)PAPR 96.143 0.021747 16957200.0 8445.5 10944.3 10679.6 11272.400000000001 11326.3 9943.099999999999 9792.3 9937.099999999999 5730.8 8146.700000000001 True False 8642.263717917684 9662.93626813297 9229.368978843677 9303.88694915464 10301.838164820678 9843.081441612467 9053.658927174038 9673.535827750131 9724.74903892852 9192.408300577938 0.9401522903823075 1.0511865826853501 1.0040207829175098 1.0121272516332518 1.120689794008931 1.0707837510866027 0.9849060911061602 1.0523396602326667 1.0579109109325695 1.0 13.16622716447126 -3.9759508432440445 1.7680249950936329 1.042003100651143 8.997910128599511e-14 0.3556387038338621 0.03900586452913989 17.32627410781754 6.02847218491867 0.010951745846238033 59.49509043935434 0.00010569371346353439 3.9759508432440445 -1.042003100651053 SAPS(ph)SPAPR ddPTM_A459_Selumetinib_30min_R2 1 SAPSSPAPR 9 0 E9PAK5;O75064 E9PAK5 DENND4B DENN domain-containing protein 4B 1 S(0.002)APS(0.499)S(0.499)PAPR 93.667 0.024264 16075000.0 80077.0 65827.0 65999.0 81149.0 89378.0 66081.0 67989.0 73375.0 67645.0 81393.0 True False 75626.64091362937 70875.71923283432 61752.69619427797 70096.36621016674 78149.53659054212 75183.05792640727 71150.62321764762 73588.50910211483 81175.8901592194 79042.97260558911 0.9567788055111913 0.8966732512261656 0.7812547296571618 0.8868133864339288 0.9886968317916751 0.9511668836337653 0.9001511566711571 0.9309936946489713 1.0269842780872271 1.0 16.27034958359122 -6.165394552020751 6.1151842834910415 0.9586268929193746 0.873213233216247 0.38515354938677104 0.05252512673455927 0.27363918176737384 14.445412035773382 0.016299994164140814 0.02115916425131509 6.832906028105404e-07 6.165394552020751 -0.08541365970312764 SAPSPT(ph)SNSTYLTMNAASR ddPTM_A459_Selumetinib_30min_R1 1 SAPSPTSNSTYLTMNAASR 19 0 Q96JM2;Q96JM2-3 Q96JM2 ZNF462 Zinc finger protein 462 1 SAPS(0.384)PT(0.477)S(0.126)NS(0.006)T(0.006)YLTMNAASR 92.264 0.012769 0.0 444.75 458.77 508.19 490.89 396.99 528.53 491.64 413.23 128.13 425.85 True False 455.11180966714676 405.056995123613 439.1805892878543 405.1652766465457 361.08232459427705 523.213468066844 454.55519897836524 402.26979803978895 217.42725175506226 480.51199563026904 0.9471393301434529 0.842969579962963 0.9139846523743868 0.8431949261019094 0.7514532995594819 1.0888666106671596 0.9459809601259647 0.8371691064905615 0.45249078843468066 1.0 8.908428637049054 -8.013556416199519 24.77695472195582 0.6991069023253939 0.9008709887741896 0.18125482034645346 0.14834112781763317 778.3662755159272 1422605.5389019954 0.08744611927780678 0.03619656037494043 9.692673502882516e-09 8.013556416199519 0.20176408644879573 SAPSS(ph)PTLDCEK ddPTM_A459_Selumetinib_30min_R1 1 SAPSSPTLDCEK 12 0 A6NIZ0;Q9GZM8-3;Q9GZM8;Q9GZM8-2;J3QSD2;J3QRZ1 A6NIZ0 NDEL1 Nuclear distribution protein nudE-like 1 1 SAPS(0.006)S(0.964)PT(0.03)LDCEK 130.69 0.0021322 5021000.0 1108.1 1344.3 1489.6 1685.6 1583.0 1251.7 1407.6 1184.5 638.89 982.75 True False 1133.9165740127378 1186.9087310518848 1287.320501787103 1391.2416026307671 1439.8179295013488 1239.1090344526688 1301.4235987347379 1153.0832122017512 1084.1496673206254 1108.8955352956366 1.022563927728711 1.0703521596698011 1.1609033139843037 1.2546191758810317 1.298425220115515 1.117426299423522 1.1736214614551337 1.039848367587064 0.9776842207517646 1.0 10.114907745914962 -7.877394466561783 3.512011747400315 0.9926524843352188 1.1617306066982562 0.45961523291119455 0.07598145302004984 0.23852724212362536 5.598169559860511 0.053284567470330134 0.023162488396938137 1.3261893422497667e-08 7.877394466561783 0.16907812236303743 SAPT(ph)SPTATNISSK ddPTM_A459_Selumetinib_30min_R1 1 SAPTSPTATNISSK 14 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 SAPT(0.59)S(0.402)PT(0.007)AT(0.001)NISSK 127.03 0.0029229 10399000.0 2870.1 3776.1 3888.2 4244.6 3124.2 2762.1 3509.0 3234.4 2037.6 2488.5 True False 2936.967745757566 3333.9924565387355 3360.2037963537978 3503.3602910100585 2841.61666162231 2734.3157817861443 3244.313304887894 3148.613205188135 3457.658379584134 2807.9232150426797 1.0459572861620878 1.1873517191203036 1.1966864971066253 1.2476695488828773 1.0119994187872114 0.9737858097891695 1.155413825957695 1.1213316618917148 1.2313934943308549 1.0 11.455287769167889 -4.726280169877224 23.02223622721741 1.127618194499533 1.0459555905611124 0.059796367353404656 0.09362200322291812 6607.5336490126765 4325917.35246206 0.024432484034408068 4.030566437168665 1.8781048323440154e-05 4.726280169877224 -0.08166260393842051 SAPTAPT(ph)PPPPPPPATPR ddPTM_A459_Selumetinib_30min_R1 1 SAPTAPTPPPPPPPATPR 18 0 A6NHN7;A6NHB5;Q14202-2;Q14202 A6NHN7 ZMYM3 Zinc finger MYM-type protein 3 1 S(0.041)APT(0.36)APT(0.599)PPPPPPPATPR 89.87700000000002 0.013934 10139000.0 2492.6 2720.1 2936.3 2620.9 2282.2 2780.2 3008.6 3088.5 1335.6 2427.4 True False 2550.6727302447007 2401.6294274598185 2537.566587941375 2163.2090153862 2075.7754129551354 2752.233712219627 2781.6588797622417 3006.5829471381253 2266.415651635535 2738.980434878279 0.9312489778182929 0.876833363567472 0.9264639336695901 0.7897862240415505 0.7578642718736264 1.0048387630567126 1.0155818728533048 1.0977015055865993 0.8274669007397474 1.0 11.41942324526365 -6.78903911037207 24.99722216878935 0.996878238032726 0.8577596479185784 0.40435222314862174 0.08023261892766866 219.51084614463693 198810.6043146134 0.02864162220708821 0.025265198870957833 1.6254023736140946e-07 6.78903911037207 -0.13911859011414762 SAPTAPT(ph)PPPPPPPATPR ddPTM_A459_Selumetinib_30min_R2 2 SAPTAPTPPPPPPPATPR 18 0 A6NHN7;A6NHB5;Q14202-2;Q14202 A6NHN7 ZMYM3 Zinc finger MYM-type protein 3 1 S(0.009)APT(0.007)APT(0.98)PPPPPPPAT(0.004)PR;S(0.366)APT(0.201)APT(0.432)PPPPPPPATPR 171.87 1.3831e-07 23347000.0 40031.0 39579.0 41505.0 47843.0 46923.0 30160.0 32522.0 36424.0 34462.0 36667.0 True False 37806.23727678976 42614.58203345661 38834.613487227165 41326.70086622159 41028.11324305761 34314.26623477918 34034.337441120435 36529.987809682185 41355.36294873261 35608.32843769282 1.0617245721866115 1.1967588455611804 1.0906047880113123 1.16059086959206 1.15220553851182 0.9636584400422507 0.9557971107987688 1.0258832529474693 1.1613957959609338 1.0 15.119927092384572 -6.749573197241738 24.96361906305632 1.0188677583006707 1.1352004832128364 0.4355025015007723 0.06313176964934362 209.27424064549135 440262.2967161478 0.021300250852437835 0.021137412551903347 1.7800278725499668e-07 6.749573197241738 0.11633272491216573 SAPTS(ph)PTATNISSK ddPTM_A459_Selumetinib_30min_R1 2 SAPTSPTATNISSK 14 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 SAPT(0.156)S(0.81)PT(0.031)AT(0.003)NISSK;SAPT(0.012)S(0.484)PT(0.484)AT(0.009)NIS(0.009)S(0.003)K 144.88 0.00052621 14927300.0 5334.8 6474.799999999999 6529.700000000001 6913.1 6093.799999999999 5928.4 6166.700000000001 5557.1 3387.8999999999996 5467.8 True False 5459.090460286216 5716.727405947141 5643.002605074681 5705.856859958924 5542.616865947771 5868.76567855652 5701.540854161349 5409.707655995233 5749.018857574144 6169.645390882199 0.8848305071720856 0.9265893003179078 0.9146396992952276 0.9248273601577356 0.8983687902288385 0.9512322518940337 0.9241278052361587 0.8768263511530114 0.9318232237577744 1.0 12.590971855476377 -8.547887724372874 23.443170860132906 1.0000000004699217 0.9141487802502328 0.6170488046356203 0.02060421644666278 2185.1433273323364 2048328.8873080474 0.019542369480732152 0.005045818054642914 2.8321240737342834e-09 8.547887724372874 -0.08585122021968883 SAPTS(ph)PTATNISSK ddPTM_A459_Selumetinib_30min_R2 2 SAPTSPTATNISSK 14 0 Q9H792;H0YN99;H3BUZ5 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 SAPT(0.159)S(0.835)PT(0.006)AT(0.001)NISSK;SAPT(0.006)S(0.99)PT(0.005)ATNISSK 187.08 8.6506e-05 27951000.0 165910.0 142876.0 155841.0 156586.0 153327.0 101475.0 156505.0 188674.0 137387.0 161008.0 True False 156689.38639035248 153834.1297812514 145814.35972685163 135258.71667408332 134064.69149922853 115452.26015166494 163782.7926087742 189223.0101033379 164868.23891351407 156359.28069097633 1.0021111999103434 0.9838503291997386 0.9325596733527742 0.8650507732982251 0.857414353064145 0.7383780460070115 1.0474772708405424 1.210180868491666 1.0544192719801173 1.0 17.254505327274963 -7.5059048745850045 24.291557444624903 1.1051458711325015 0.8984509630762577 0.5234063535977104 0.08502117860697773 386.3796502997055 552956.6522324837 0.03814746395992044 0.024993735200919336 3.119572802907268e-08 7.5059048745850045 -0.2066949080562438 SAPYQWPS(ph)PEAGIELMR ddPTM_A459_Selumetinib_30min_R1 1 SAPYQWPSPEAGIELMR 17 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4;F6QUH3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 SAPYQWPS(1)PEAGIELMR 169.58 9.9343e-07 3697300.0 1047.5 970.41 1199.6 1116.2 1246.6 942.73 1062.9 921.42 592.23 777.65 True False 1071.9047119198115 856.79394606863 1036.700908931129 921.2766236689976 1133.845250105105 933.2469921303533 982.7245972543008 896.980948406026 1004.9710552321909 877.4689524524572 1.2215870532215658 0.9764379054939298 1.1814673397088649 1.0499250384803944 1.2921770587279424 1.0635669666966574 1.1199536969458148 1.0222366795987872 1.145306682844305 1.0 9.777204269111804 -9.125795354071307 0.49584552238095625 0.9942358585484524 1.1275636042246 0.14043433607560718 0.09056707222535923 4.663630835496189 1.930517878478438 0.16337733317376654 0.045558240257542425 7.485221320275593e-10 9.125795354071307 0.13332774567614758 SAPYQWPS(ph)PEAGIELMR ddPTM_A459_Selumetinib_30min_R2 2 SAPYQWPSPEAGIELMR 17 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4;F6QUH3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 S(0.001)APYQWPS(0.999)PEAGIELMR;SAPYQWPS(1)PEAGIELMR 144.25 0.00036242 1623500.0 20822.1 15848.4 23758.3 24433.3 27082.6 18348.0 19410.6 22541.8 15689.1 19853.5 True False 19664.891039470513 17063.921319362114 22229.71684408118 21105.44239020654 23680.241666484086 20875.27045343926 20313.231361374223 22607.392906004116 18827.358390080673 19280.277869412123 1.019948528369945 0.8850454041657654 1.1529769951784927 1.094664845245307 1.2282106008468083 1.082726638839452 1.053575653782504 1.1725657202207864 0.9765086643253208 1.0 14.234838223541292 -5.265722477102813 24.998794752697904 1.1041225302210518 0.9524969637959905 0.34058348667813976 0.07861140736124704 329.53380841277635 1923373.3414793082 0.019511512076639065 0.0430503351539484 5.4234735054294065e-06 5.265722477102813 -0.1516255664250613 SAQGSS(ph)SPVPSMVQK ddPTM_A459_Selumetinib_30min_R1 1 SAQGSSSPVPSMVQK 15 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGSS(0.499)S(0.499)PVPS(0.002)MVQK 168.93 6.2769e-05 24495000.0 6782.1 8497.2 7956.2 8442.5 8117.1 6592.7 7799.2 7512.2 3954.4 6699.6 True False 6940.109734330652 7502.343873758892 6875.791740278296 6968.175860352544 7382.9097381904 6526.383423692661 7210.90006482806 7312.952052935419 6710.327982051189 7559.558919630271 0.9180574962262593 0.9924314306588966 0.9095493286550881 0.9217701633699746 0.9766323427969908 0.8633286006601902 0.9538784129459151 0.9673781407993955 0.8876613111151441 1.0 12.88408634410497 -10.746058948653626 4.910314130454911 1.0000101138106334 0.9340302971100402 0.21588076887904095 0.03858137489063027 4.076263866131754e-06 6.448832458757644e-07 0.03564683640959517 0.008644302663775824 1.7944900364681456e-11 10.746058948653626 -0.06597981670059327 SAQGSS(ph)SPVPSMVQK ddPTM_A459_Selumetinib_30min_R2 2 SAQGSSSPVPSMVQK 15 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGS(0.124)S(0.752)S(0.124)PVPSMVQK;SAQGS(0.006)S(0.883)S(0.111)PVPSMVQK 273.84 2.8021999999999997e-45 91202000.0 484680.0 381390.0 489640.0 575990.0 567160.0 382080.0 417370.0 445410.0 361780.0 399040.0 True False 457743.4259277678 410641.38663786463 458137.0954797223 497539.1683618293 495908.29032526864 434708.0518230904 436778.5320029649 446706.0693584048 434146.10897778656 387518.67836956755 1.1812164199508044 1.0596686290466895 1.182232292407871 1.2839101600344998 1.2797016453806451 1.1217731585276502 1.127116075644796 1.1527342920291228 1.1203230533413193 1.0 18.563906324286165 -6.960138975550329 24.974335000949488 1.1144387378567064 1.1943737379766517 0.3031359111890255 0.06965754302437681 248.22650871569522 155521.91942916156 0.026687652908237353 0.023536283330455567 1.0961273759323247e-07 6.960138975550329 0.07993500011994525 SAQGSSS(ph)PVPSMVQK ddPTM_A459_Selumetinib_30min_R1 2 SAQGSSSPVPSMVQK 15 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGSS(0.032)S(0.834)PVPS(0.135)MVQK;SAQGS(0.021)S(0.221)S(0.758)PVPSMVQK 247.02 7.414999999999998e-28 28560100.0 8326.4 10371.5 8435.3 9903.7 9247.5 7732.7 9769.9 8503.6 4652.8 7351.700000000001 True False 8520.388919645935 9157.19995842046 7289.832591786221 8174.2047104736175 8411.065257778728 7654.9160587298475 9032.948577208386 8278.056904414363 7895.461772933381 8295.362306622164 1.0271267974448968 1.103893913242378 0.8787841112095572 0.985394538337183 1.0139479081057374 0.9227946623402994 1.0889154980002993 0.9979138461265294 0.9517922763458392 1.0 13.018089278085816 -5.223202094953541 24.996351270953028 0.9831283288398472 1.0655103562735877 0.27220112780648753 0.05577239428666553 751.5128748859205 491274.1773389967 0.014001099219893363 0.03704192466979411 5.981331944941519e-06 5.223202094953541 0.08238202743374046 SAQGSSS(ph)PVPSMVQK ddPTM_A459_Selumetinib_30min_R2 5 SAQGSSSPVPSMVQK 15 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGSS(0.003)S(0.802)PVPS(0.195)MVQK;SAQGS(0.002)S(0.014)S(0.973)PVPS(0.01)MVQK;SAQGSS(0.034)S(0.832)PVPS(0.134)MVQK;SAQGS(0.002)S(0.205)S(0.792)PVPS(0.002)MVQK;SAQGS(0.062)S(0.211)S(0.72)PVPS(0.007)MVQK 243.99 1.6093e-20 121455900.0 640373.0 520376.0 660236.0 731458.0 738981.0 497161.0 557681.0 583972.0 503389.0 563653.0 True False 604783.6322762277 560287.1659274377 617757.1345706036 631832.1585645699 646143.6002060393 565640.4149717847 583614.2715239372 585671.2618382304 604080.8658638364 547378.8733436302 1.1048720762311195 1.0235820072940667 1.1285732143753961 1.1542867095053595 1.1804321132438136 1.0333617947594598 1.0661980210506943 1.0699559123659514 1.1035882005709237 1.0 19.06218022790008 -6.790702941474766 24.999996885944416 1.059716608395014 1.1156489881625944 0.32458491950916 0.045586697759358204 317.4290321142521 271178.6801848789 0.017269225856049855 0.0152324656071756 1.6191871870890582e-07 6.790702941474766 0.055932379767580365 SAQGSSSPVPS(ph)MVQK ddPTM_A459_Selumetinib_30min_R1 1 SAQGSSSPVPSMVQK 15 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGSS(0.001)S(0.006)PVPS(0.992)MVQK 111.86 0.011956 4728200.0 2183.0 2733.5 2584.5 2926.4 2390.4 1978.1 2644.1 2828.6 1107.2 2322.7 True False 2233.859652621432 2413.4605492303263 2233.539095642299 2415.359175331441 2174.188742059396 1958.2021099710978 2444.653408222878 2753.5763394123055 1878.8375333115189 2620.8411700139163 0.8523445366243123 0.9208724957634541 0.8522222259010221 0.9215969296295111 0.8295766897037303 0.7471655025782047 0.9327743459592774 1.0506460181246635 0.71688340171394 1.0 11.355814209798668 -10.663884061991771 4.9158707783189035 1.0000070352612136 0.8743264895794092 0.1545298811946788 0.09101557290188739 7.403250778422558e-06 1.29372839062507e-06 0.08691039754473297 0.02107760570272476 2.1682828661338264e-11 10.663884061991771 -0.12568054568180442 SAQGSSSPVPSMVQKS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SAQGSSSPVPSMVQKSPR 18 1 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGSSSPVPS(0.003)MVQKS(0.997)PR 106.12 0.00092567 22151000.0 1604.2 1640.1 2952.5 3084.7 2057.7 1731.9 1849.2 1571.0 1128.1 1397.8 True False 1641.5747387701792 1448.0763295381962 2551.5667169216035 2546.015051990464 1871.581398316441 1714.478658439383 1709.713355200538 1529.3319766728164 1914.3033068359152 1577.2212457249982 1.0408018172590616 0.918118706213954 1.6177608080271135 1.6142409055745013 1.1866321249408067 1.0870248312254327 1.0840035028913382 0.9696369363638843 1.213718945280864 1.0 10.623169333961041 -6.520027218827074 13.8050430069408 1.077223518441496 1.3068410531512686 0.20239801874019592 0.2119809259494224 0.700557241791653 3348.4179460701025 0.07605417758126458 0.07883462418469174 3.0197624548892043e-07 6.520027218827074 0.22961753470977264 SAQGSSSPVPSMVQKS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SAQGSSSPVPSMVQKSPR 18 1 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;A0A494BZU9 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SAQGSSSPVPSMVQKS(1)PR;SAQGSSSPVPS(0.032)MVQKS(0.968)PR 168.4 6.3112e-08 51071000.0 67072.0 75753.0 73142.0 80840.0 76147.0 52481.0 38105.0 34055.0 27891.0 71871.0 True False 63344.40675048947 81563.01151571386 68436.12335098826 69829.4525432217 66580.7330971828 59709.7813749153 39876.95800362506 34154.094411891245 33469.9793396524 69795.89748671601 0.9075663331436574 1.168593204654148 0.9805178501216844 1.0004807597253418 0.9539347654330953 0.8554912756337811 0.5713367037255261 0.48934243475258216 0.4795407831244323 1.0 16.090854618713422 -7.037516301292168 2.320649978089609 0.5907503736753186 1.0135123833423494 0.5559689677669765 0.1522338234620466 0.1980049762341583 2.1226560589088463 0.06273945655928205 0.04833175625559102 9.17241505980655e-08 7.037516301292168 0.4227620096670308 SAQS(ph)SPECAAAR ddPTM_A459_Selumetinib_30min_R2 1 SAQSSPECAAAR 12 0 Q14147;H7C504 Q14147 DHX34 Probable ATP-dependent RNA helicase DHX34 1 S(0.075)AQS(0.462)S(0.462)PECAAAR 95.751 0.019615 0.0 7524.7 6392.3 9530.5 10768.0 13800.0 8875.8 5273.8 8333.2 13337.0 10909.0 True False 7106.50729776074 6882.568855515916 8917.318006023817 9301.37982416391 12066.320626434695 10098.360883509715 5519.042149836447 8357.448232364472 16004.772666915627 10594.028825014064 0.6708030924912369 0.6496649168317492 0.8417305779807503 0.8779832467702922 1.1389737394280384 0.9532125171932698 0.5209578188804975 0.7888829047388756 1.5107352388098094 1.0 13.370963718693673 -3.788204403278629 0.3483623192981846 1.007483379898899 7.361175403406477e-33 0.21191002485491262 0.23784508489879516 25.14903841269098 1.425768920266055 0.22962305343014583 12.188923911343359 0.0001628529375210235 3.788204403278629 -1.007483379898899 SAQSLPAAT(ph)PPTQK ddPTM_A459_Selumetinib_30min_R1 1 SAQSLPAATPPTQK 14 0 J3KT46;J3QS60;O94989 J3KT46 ARHGEF15 Rho guanine nucleotide exchange factor 15 1 SAQS(0.002)LPAAT(0.771)PPT(0.227)QK 93.442 0.03375 3453300.0 589.36 796.45 814.19 875.58 680.34 657.96 839.04 605.17 379.58 422.72 True False 603.0909413050695 703.2012637404403 703.6274700255385 722.6763896721924 618.8033671237831 651.3415197798817 775.7505372850206 589.1189257308012 644.1195365736875 476.98022964148737 1.2643940017353983 1.4742775906435104 1.4751711419033153 1.515107639189527 1.2973354631257867 1.3655524470468083 1.6263788079185126 1.2351013503716928 1.3504113934823399 1.0 8.897785658962972 -8.873920864470989 1.024689261047118 1.001075479208691 1.4248126155471914 0.5405308981269996 0.11336951549502287 0.8937621033918296 1.6122220902710631 0.1074272330039497 0.03430403794481357 1.3368390882126205e-09 8.873920864470989 0.4237371363385003 SAS(ph)ADNLTLPR ddPTM_A459_Selumetinib_30min_R2 1 SASADNLTLPR 11 0 Q8ND76-3;Q8ND76-2;Q8ND76 Q8ND76-3 CCNY Cyclin-Y 1 S(0.239)AS(0.761)ADNLTLPR 104.7 0.012121 31929000.0 41854.0 23709.0 34308.0 33940.0 29803.0 26341.0 45763.0 32851.0 33908.0 30798.0 True False 39527.92223483699 25527.40406354941 32100.66063172607 29317.313450234335 26058.88069779952 29969.233650209488 47891.07017766416 32946.59097122418 40690.547468679266 29908.7817171861 1.3216159256705386 0.8535086552482652 1.073285462954196 0.9802242608025757 0.8712785744404172 1.0020212101447332 1.6012377445031514 1.1015691405542105 1.3604882958271007 1.0 14.868281525500858 -7.109453656359915 22.0669387294497 1.2782081843926594 1.003729086938908 0.2862993097078429 0.1913841149769039 12.449481630991366 2495.0868604192074 0.06850283259785254 0.0530621162207464 7.772242521044992e-08 7.109453656359915 -0.27447909745375143 SAS(ph)AGPAGESKPK ddPTM_A459_Selumetinib_30min_R1 2 SASAGPAGESKPK 13 1 F5H5Z1;H0YGL7;F5H510;Q8N5U6;Q8N5U6-2 F5H5Z1 RNF10 RING finger protein 10 1 SAS(1)AGPAGESKPK;S(0.015)AS(0.985)AGPAGESKPK 120.32 0.001682 12074700.0 4823.1 5413.1 5579.9 5823.0 5820.0 5942.799999999999 5751.5 5692.8 3416.0 5198.4 True False 4935.46884588109 4779.331735518084 4822.180228196735 4806.122361247602 5293.582027604457 5883.020827630673 5317.659724440784 5541.808451179514 5796.702505231349 5865.665276703981 0.841416721387555 0.8147978976058575 0.8221028648444122 0.8193652611470263 0.9024691621304058 1.0029588375926632 0.9065740156637218 0.9447877077454976 0.9882429753115092 1.0 12.51807903093299 -6.448016100599627 3.3788876132858725 0.9611527297992407 0.8238166186553343 0.8514856860851551 0.0281934441734866 0.09328157250264694 2.060896657865017 0.00926886332834091 0.010327499246608245 3.564379189580803e-07 6.448016100599627 -0.13733611114390643 SAS(ph)APTLAETEK ddPTM_A459_Selumetinib_30min_R2 1 SASAPTLAETEK 12 0 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.007)AS(0.993)APTLAETEK 206.46 1.0308e-05 21706000.0 88437.0 85522.0 75813.0 72757.0 80241.0 78445.0 108240.0 93657.0 99996.0 66182.0 True False 83522.02558136095 92081.26240342809 70935.27411895334 62847.371087174324 70160.40821635838 89250.08669718997 113273.37447349096 93929.52636424903 119997.99412168365 64271.15369851319 1.299525849079213 1.4326996965912289 1.1036875804610664 0.9778472529368677 1.09163138015961 1.388649208256777 1.762429456375409 1.4614569827835833 1.8670583491402242 1.0 15.971883749235088 -6.977996732736235 5.345503425678649 1.5642130554203852 1.182370933476905 0.30047259898663314 0.24353523071592661 0.19923792177900043 16.520082310696047 0.08709098604946246 0.07435263714656447 1.0519697879229503e-07 6.977996732736235 -0.3818421219434802 SAS(ph)APTLAETEKETAEHLDLAGASSRPK ddPTM_A459_Selumetinib_30min_R1 1 SASAPTLAETEKETAEHLDLAGASSRPK 28 2 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.311)AS(0.589)APT(0.082)LAET(0.013)EKET(0.005)AEHLDLAGASSRPK 51.659 0.0082914 9377900.0 2614.5 2696.9 3823.6 4148.4 3218.2 3089.0 3006.8 2939.6 1557.9 1700.4 True False 2675.41276306859 2381.145694245204 3304.3761215313966 3423.959815112407 2927.114378219358 3057.927464587593 2779.994655211433 2861.6322588334915 2643.6425154859244 1918.6629032986016 1.3944152245133679 1.2410443179734665 1.7222285977648553 1.784555176016522 1.5256011742276392 1.5937804704152805 1.4489229194101858 1.491472136097341 1.3778566891249755 1.0 10.905885546242681 -8.87612313991959 0.9653202533939942 0.9990807475711502 1.542566509337072 0.5451239657576552 0.1458991161197053 1.007181651089712 1.637948594492654 0.15539090250308757 0.05052024963264711 1.3300772342177905e-09 8.87612313991959 0.5434857617659218 SAS(ph)ASHQADIK ddPTM_A459_Selumetinib_30min_R1 3 SASASHQADIK 11 0 C9JXK0;A0A494C1L1;Q14739 C9JXK0 LBR Lamin-B receptor 1 S(0.125)AS(0.872)AS(0.003)HQADIK;S(0.081)AS(0.459)AS(0.459)HQADIK;S(0.019)AS(0.491)AS(0.491)HQADIK 162.67 0.00054936 65221600.0 6061.700000000001 8942.6 9304.8 7140.1 10089.099999999999 9576.8 9546.2 9905.1 4280.360000000001 7896.6 True False 6202.925815985037 7895.59623469805 8041.2592676078375 5893.215571276661 9176.542686375276 9480.46608703868 8826.122448310287 9642.38457170078 7263.458294874724 8910.205529397635 0.6961596784181452 0.8861295296329514 0.902477416606961 0.6614006323235806 1.029891247300515 1.0640008309302822 0.9905632837750004 1.0821730811806138 0.8151841470895634 1.0 13.12124299506505 -6.283834021440749 24.976913746082438 1.0041087639973785 0.8019363294734717 0.5266867649150966 0.09714664668038314 640.0719188466429 713875.0057576793 0.02952644093645658 0.03350413641723331 5.201947664572427e-07 6.283834021440749 -0.20217243452390676 SAS(ph)ASHQADIK ddPTM_A459_Selumetinib_30min_R2 2 SASASHQADIK 11 0 C9JXK0;A0A494C1L1;Q14739 C9JXK0 LBR Lamin-B receptor 1 S(0.251)AS(0.748)AS(0.001)HQADIK;S(0.139)AS(0.757)AS(0.104)HQADIK 104.41 0.012326 45917000.0 109086.0 36066.3 83808.0 97648.0 51921.0 46697.5 127208.0 96888.0 84017.0 72517.0 True False 103023.4368258573 38832.46923856732 78415.88452325099 84348.17394780427 45398.219800370716 53129.656747301065 133123.42405787 97169.92803932822 100822.74763112032 70423.24578820664 1.4629180418024699 0.5514154992991016 1.1134943248580405 1.1977319847124905 0.6446482165406424 0.7544335134322703 1.890333547792303 1.37979905572033 1.4316685705503864 1.0 16.103764101704144 -7.24331707696293 24.997520114752913 1.4571002606345569 0.9400552088613154 0.33547805761559946 0.3234006338823739 858.9172843352206 1184773.8350647537 0.11973406152556328 0.09256036619658882 5.710615542856323e-08 7.24331707696293 -0.5170450517732414 SAS(ph)DSGCDPASK ddPTM_A459_Selumetinib_30min_R2 1 SASDSGCDPASK 12 0 Q7LBC6;H0Y9V5 Q7LBC6 KDM3B Lysine-specific demethylase 3B 1 S(0.374)AS(0.567)DS(0.059)GCDPASK 137.62 0.0013085 19371000.0 61498.0 52893.0 53238.0 59460.0 53324.0 49872.0 74344.0 101470.0 86998.0 119060.0 True False 58080.18735599953 56949.72302219914 49812.7250411517 51361.44542577883 46624.96239739159 56741.41530705923 77801.14330984131 101765.26090073714 104400.0309272195 115622.42844496944 0.5023263058658453 0.492549099583256 0.430822338806524 0.44421697517125186 0.4032518865453753 0.490747479275315 0.6728897183375698 0.8801515611581568 0.9029392681966436 1.0 16.819061753484604 -7.593492476316613 1.6541331830541295 0.9535438347154838 0.4517313024248117 0.9741757534677855 0.03429172169912564 0.05904035158944633 0.313294127305186 0.025570738282277083 0.011673986880491647 2.5498082600940634e-08 7.593492476316613 -0.5018125322906721 SAS(ph)EPSLHR ddPTM_A459_Selumetinib_30min_R1 4 SASEPSLHR 9 0 H7C155;P04049;P04049-2;P10398;Q96II5 H7C155;P10398 RAF1;ARAF RAF proto-oncogene serine/threonine-protein kinase;Serine/threonine-protein kinase A-Raf 1 S(0.002)AS(0.998)EPSLHR;S(0.111)AS(0.889)EPSLHR;S(0.086)AS(0.914)EPSLHR;S(0.013)AS(0.987)EPSLHR 139.43 0.0023803 176799300.0 16397.8 19929.6 21881.2 22157.800000000003 18296.9 17282.3 18264.7 16456.7 10869.04 16802.9 True False 16779.836835435497 17596.233166980317 18909.853224828126 18288.35618341957 16641.948625580073 17108.455753072903 16886.97897400566 16020.214857104751 18443.96703672709 18959.71588910613 0.8850257532116741 0.9280852766939803 0.9973700732347655 0.9645902022154083 0.8777530593241748 0.9023582343289794 0.8906767945667675 0.8449607025129339 0.9727976486886398 1.0 14.210649725196555 -4.759000214985101 23.494017410652948 0.9254214106818568 0.8850256438408651 0.06093898488016092 0.05000966963412724 111.24622146526764 1070995.3624441987 0.012943861478756724 0.08415945515629687 1.741806011159995e-05 4.759000214985101 -0.040395766840991665 SAS(ph)EPSLHR ddPTM_A459_Selumetinib_30min_R2 2 SASEPSLHR 9 0 H7C155;P04049;P04049-2;P10398;Q96II5 H7C155;P10398 RAF1;ARAF RAF proto-oncogene serine/threonine-protein kinase;Serine/threonine-protein kinase A-Raf 1 S(0.001)AS(0.997)EPS(0.002)LHR;S(0.004)AS(0.995)EPSLHR 99.973 0.014368 108911300.0 59403.0 50267.0 60544.0 83897.0 88855.0 67657.0 57274.0 56420.0 65451.0 73468.0 True False 56101.61906905004 54122.31726611994 56648.66495532299 72470.08386960239 77692.24052622133 76976.13762090373 59937.35448627798 56584.17285916616 78543.02885373749 71346.78794721192 0.7863229822001029 0.7585809932489739 0.7939904035656968 1.0157441694953606 1.0889381675276577 1.078901234879093 0.8400848336805918 0.7930864792544223 1.1008628575101365 1.0 16.12256086016935 -5.728575953012761 7.619776738206341 0.981412386532534 0.7762333437553144 0.4947631571864105 0.09642972592353281 0.1957925427120519 36.04903017480035 0.028845863133353952 0.04931445904461489 1.8682029218975738e-06 5.728575953012761 -0.20517904277721966 SAS(ph)EPSLNR ddPTM_A459_Selumetinib_30min_R1 3 SASEPSLNR 9 0 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 S(0.048)AS(0.949)EPS(0.003)LNR;S(0.016)AS(0.538)EPS(0.446)LNR;S(0.222)AS(0.771)EPS(0.007)LNR 134.57 0.002852 75957000.0 4894.2 5822.3 5733.8 6169.8 6076.3 5391.4 5478.599999999999 4786.42 3063.3900000000003 4248.18 True False 5008.225337544576 5140.622409286166 4955.1814535089225 5092.360251489863 5526.699737857898 5337.167410999531 5065.344791153832 4659.4685931166805 5198.349088846801 4793.475283777381 1.0448004925557823 1.072420760504104 1.0337346413944817 1.0623524582934645 1.1529630196617426 1.1134233713611028 1.056716576446434 0.9720439383271212 1.0844635219961682 1.0 12.226856278145709 -7.530575657795874 24.892690152714334 1.0198282735139939 1.0804456295432712 0.30478812101910036 0.04128531865562824 231.6156596027931 749058.232517595 0.02021993093625762 0.011699892888300976 2.947299987132732e-08 7.530575657795874 0.060617356029277314 SAS(ph)EPSLNR ddPTM_A459_Selumetinib_30min_R2 2 SASEPSLNR 9 0 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 S(0.011)AS(0.934)EPS(0.055)LNR;S(0.013)AS(0.959)EPS(0.028)LNR 115.57 0.0081236 74940000.0 137222.0 142579.0 176632.0 146472.0 200911.0 142919.0 110694.0 141064.0 127959.0 178374.0 True False 129595.75058318923 153514.35083625672 165267.68942238064 126522.26092170687 175670.7640128709 162604.79496049084 115841.49033599973 141474.4728855975 153554.37547318393 173223.87914869015 0.7481402172730941 0.8862193341397501 0.9540699021092806 0.7303973421187733 1.014125563266485 0.9386973421886933 0.6687385763747092 0.8167146099075641 0.886450391411553 1.0 17.402278295695297 -4.7564096990703435 24.718838716847827 0.8690307068768716 0.7481400015719235 0.1130345710929046 0.10628386403139037 340.8791705259582 1675061.4997755555 0.026579377872640888 0.21410841200369962 1.752226729083459e-05 4.7564096990703435 -0.12089070530494805 SAS(ph)FAFEFPK ddPTM_A459_Selumetinib_30min_R1 2 SASFAFEFPK 10 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 S(0.19)AS(0.81)FAFEFPK;S(0.206)AS(0.794)FAFEFPK 132.56 0.0024188 42737000.0 7768.700000000001 8931.1 7035.6 7009.799999999999 7949.7 6857.9 8468.1 8695.2 4319.7 7118.1 True False 7949.6955947412325 7885.442660044253 6080.2041637844695 5785.670020242735 7230.651038633526 6788.915752474998 7829.344399293581 8464.57505000985 7330.215401594806 8031.777471165481 0.9897803597374396 0.9817805197359392 0.757018503763673 0.7203474001880164 0.9002553998279904 0.8452569530029406 0.9747959810143338 1.0538856536299885 0.9126517047951938 1.0 12.971503583122415 -7.310272548740403 5.480651460256682 0.9915015717610849 0.8609732438484539 0.3161148820927596 0.08596391392861623 0.2742383371159859 19.66984808250113 0.039816766445067785 0.02688745148404566 4.8947154693437595e-08 7.310272548740403 -0.13052832791263103 SAS(ph)FAFEFPK ddPTM_A459_Selumetinib_30min_R2 2 SASFAFEFPK 10 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 S(0.01)AS(0.99)FAFEFPK;S(0.003)AS(0.997)FAFEFPK 121.02 0.0036068 11368000.0 52997.0 35386.0 56363.0 62949.0 56974.0 50718.0 50181.0 56410.0 44451.0 46167.0 True False 50051.63890380023 38099.99241607657 52736.665943394444 54375.23760691811 49816.416765977556 57703.944127835886 52514.51593176513 56574.14376082177 53342.44206471222 44834.038753728506 1.116375867423673 0.8498005862322204 1.176264004076785 1.212811495872567 1.111129359539011 1.2870565697817506 1.171309063192481 1.2618569580934067 1.1897755265306347 1.0 15.45230684609234 -5.362050005125776 8.20299827717974 1.1890881595338867 0.9837557037691523 0.38558486181015694 0.0965438875232052 0.23833693779266138 17.309322008210625 0.023220186722982837 0.04852963804067179 4.344601970851435e-06 5.362050005125776 -0.20533245576473436 SAS(ph)FNTDPYVR ddPTM_A459_Selumetinib_30min_R2 1 SASFNTDPYVR 11 0 Q9UKV8-2;Q9UKV8 Q9UKV8-2 AGO2 Protein argonaute-2 1 S(0.049)AS(0.948)FNT(0.003)DPYVR 159.58 0.00058807 4423300.0 33592.0 34412.0 37117.0 39958.0 39593.0 25113.0 21341.0 26876.0 26452.0 27170.0 True False 31725.091119430497 37051.28974798019 34728.93262993402 34515.65146860526 34618.97337408905 28572.087796883578 22333.39878638925 26954.204710438684 31743.13913063301 26385.531503862156 1.202366953069972 1.404227530628172 1.3162112207158156 1.308127958822928 1.3120438134445664 1.082869518573138 0.8464259582233628 1.0215524635724427 1.2030509647299181 1.0 14.68745942467847 -6.824070231031614 4.155603301953815 1.013349752304424 1.3156656532046636 0.6952185198689984 0.09252136129354159 0.12203426664033959 4.201924899973428 0.03391667469755352 0.030415985741949876 1.4994423366869813e-07 6.824070231031614 0.30231590090023963 SAS(ph)FSQGTR ddPTM_A459_Selumetinib_30min_R2 2 SASFSQGTR 9 0 Q9UQC2;Q9UQC2-2 Q9UQC2 GAB2 GRB2-associated-binding protein 2 1 S(0.01)AS(0.872)FS(0.118)QGTR;S(0.044)AS(0.912)FS(0.044)QGTR 110.08 0.011061 25303000.0 36081.0 43470.0 50795.0 51997.0 49113.0 36602.0 33570.0 41311.0 32157.0 44849.0 True False 34075.762463686944 46804.009221919645 47526.90500141437 44914.91890017188 42942.985864209244 41643.59326012557 35131.07151769305 41431.208170595775 38589.29854165152 43554.09283830377 0.782377963655322 1.0746179330535321 1.091215587427336 1.031244504779843 0.9859690115378299 0.956135016167803 0.8066078117645222 0.951258664126256 0.8860085476907019 1.0 15.410520676790997 -6.900765300647302 3.521716477486442 0.904312100301924 1.0054866027742921 0.13888028654188245 0.09197177556053861 0.3930359839297754 9.526148677808088 0.03422926171433808 0.029715092072342516 1.2567089248616218e-07 6.900765300647302 0.10117450247236814 SAS(ph)HTEGTHDYGR ddPTM_A459_Selumetinib_30min_R2 1 SASHTEGTHDYGR 13 0 O60303;A0A087X098;H3BNJ6 O60303 KIAA0556 Uncharacterized protein KIAA0556 1 S(0.212)AS(0.785)HT(0.003)EGTHDYGR 89.506 0.014797 433620.0 1003.5 660.6 2349.9 2024.5 2956.6 890.12 3127.0 2577.4 833.07 2577.2 True False 947.7294873287836 711.265895836212 2198.7099923776677 1748.7596075427036 2585.16547566064 1012.7259502951464 3272.411696032952 2584.8998072884597 999.7072779206269 2502.789539630235 0.37866926975761706 0.2841892554582497 0.8785037485423195 0.6987241954835193 1.0329136488410349 0.4046388776440098 1.3075057427786843 1.032807499934795 0.3994372127942986 1.0 11.2893212641032 -5.26256379735001 24.8300366170621 0.8478636798164988 0.331429227440214 0.3662728904894993 0.2698227523710129 87.99313120721004 1943175.6058327495 0.06824362987006094 0.15625234431972276 5.463062922335517e-06 5.26256379735001 -0.5164344523762847 SAS(ph)ITNLSLDR ddPTM_A459_Selumetinib_30min_R2 1 SASITNLSLDR 11 0 Q9Y2I7;E9PDH4;Q9Y2I7-2;Q9Y2I7-3;Q9Y2I7-4 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 S(0.301)AS(0.695)IT(0.004)NLSLDR 124.47 0.0035638000000000006 6064200.0 23515.0 30308.0 24828.0 32791.0 29927.0 23042.0 23873.0 30260.0 23046.0 27835.0 True False 22208.130438003333 32632.526144420095 23230.59351068249 28324.809232369866 26167.302709225463 26215.826345549794 24983.14180345207 30348.051590187322 27655.843959041602 27031.33122598464 0.8215699867809371 1.2072112124855747 0.8593950966185276 1.0478510656974909 0.9680360353126596 0.9698311239791655 0.9242290582950021 1.1226991129839137 1.0231032918000218 1.0 14.722344942322328 -7.755182460015341 24.999946601091274 1.054675902316257 0.9787190547157196 0.10087629322470715 0.10377749346643404 333.39021507019874 1332097.2530224205 0.046478198185459424 0.025987212280922718 1.7571852131410342e-08 7.755182460015341 -0.07595684760053745 SAS(ph)LSNLHSLDR ddPTM_A459_Selumetinib_30min_R2 3 SASLSNLHSLDR 12 0 B0QY53;B0QY54;A0A087WUW0;Q9Y3M2 B0QY53 CBY1 Protein chibby homolog 1 1 S(0.002)AS(0.982)LS(0.015)NLHSLDR;S(0.167)AS(0.821)LS(0.012)NLHSLDR;S(0.013)AS(0.944)LS(0.008)NLHS(0.035)LDR 112.03 0.004331499999999999 7740300.0 44834.2 35884.0 42115.2 55350.0 55684.0 42109.6 40574.8 45265.9 40282.3 44641.4 True False 42342.494649522814 38636.18741475419 39405.5538835627 47811.23451592428 48688.47809872386 47909.815167110646 42461.608597440936 45397.616274826854 48339.885581502254 43352.486789713366 0.976702786507043 0.8912104074251571 0.9089571741225422 1.102848718871391 1.1230838575626212 1.1051226518908401 0.979450355487247 1.0471744445718567 1.115042968953105 1.0 15.403827131388413 -5.7567203095675525 24.99998098748755 1.069708350578315 0.9221821153690873 0.6292458708452664 0.04987667677264482 75.74588087430133 401268.6299103828 0.01427976830925515 0.023732549413488707 1.7509739721286913e-06 5.7567203095675525 -0.14752623520922759 SAS(ph)NGHVPGTPVYR ddPTM_A459_Selumetinib_30min_R2 1 SASNGHVPGTPVYR 14 0 A0A087WX19;A0A087WX45;Q6IPM2-2;Q6IPM2-3;Q6IPM2-4;Q6IPM2;C9JP75 A0A087WX19 IQCE IQ domain-containing protein E 1 S(0.067)AS(0.933)NGHVPGTPVYR 108.66 0.0048167 4551400.0 12917.0 13360.0 16767.0 18131.0 22938.0 8691.6 10084.0 17490.0 12865.0 14106.0 True False 12199.124850847938 14384.669040829236 15688.229474529291 15661.526522280457 20056.323371678198 9888.789005510831 10552.925981066923 17540.89300437463 15438.359478133732 13698.723128210513 0.8905300688737645 1.050073711702817 1.1452329773876282 1.1432836751060278 1.4641016672842404 0.7218766970438522 0.7703583671484474 1.2804764969847249 1.126992591473047 1.0 13.741753803943311 -6.778212134863854 24.998108453833815 0.9843718754252904 1.1343477508380788 0.13610631336350965 0.19961307073098236 604.2005313129289 900494.5320324943 0.07563005407024262 0.06687846365945171 1.6664330302164485e-07 6.778212134863854 0.14997587541278845 SAS(ph)NKSPLVLEANR ddPTM_A459_Selumetinib_30min_R1 1 SASNKSPLVLEANR 14 1 Q92560;F8W6N3 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 S(0.01)AS(0.559)NKS(0.43)PLVLEANR 78.166 0.021261 5607800.0 2134.6 2384.9 2304.7 2111.2 2261.9 2165.9 2343.0 2253.6 1405.4 1981.7 True False 2184.3320267914364 2105.67479929007 1991.7343988109133 1742.518552132223 2057.3115443708807 2144.1130124798556 2166.265623639878 2193.827207275532 2384.86115364524 2236.070498392637 0.9768618781749537 0.9416853363092532 0.8907296975845078 0.7792771083849119 0.9200566555704508 0.9588754084547497 0.9687823461724766 0.9811082471919061 1.0665411288953361 1.0 11.126749958566858 -7.320703966821771 1.2983855562594881 1.0214756620949634 0.8984823018508782 0.4745729353810617 0.052170945986105215 0.4394108810098059 1.4323119875872574 0.03751456988218974 0.02060640800928375 4.778548884314989e-08 7.320703966821771 -0.12299336024408525 SAS(ph)PCIADK ddPTM_A459_Selumetinib_30min_R1 1 SASPCIADK 9 0 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 S(0.002)AS(0.998)PCIADK 88.134 0.031598 9050900.0 4188.3 4778.5 4520.5 5175.5 4646.0 3973.1 4938.4 4991.7 2989.5 4482.1 True False 4285.879240986868 4219.030998535616 3906.640929329082 4271.696081167263 4225.770120317922 3933.134221286168 4565.892512071348 4859.303900673268 5072.963155558873 5057.421194351132 0.8474436034265774 0.8342257519006026 0.7724571039668577 0.8446391781523989 0.8355582732634333 0.777695602193321 0.9028104119884667 0.9608264200143839 1.0030731000267687 1.0 12.304186219286555 -7.6267034231738515 2.2762423674660295 0.9946556165441657 0.8192621497438872 0.8917073621611821 0.02652447743577885 0.09270244728887694 0.9608722362294791 0.01612139964750985 0.00779187983013472 2.3620907386588498e-08 7.6267034231738515 -0.17539346680027845 SAS(ph)PDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R1 3 SASPDDDLGSSNWEAADLGNEER 23 0 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 S(0.224)AS(0.776)PDDDLGSSNWEAADLGNEER;S(0.026)AS(0.974)PDDDLGSSNWEAADLGNEER;S(0.412)AS(0.588)PDDDLGSSNWEAADLGNEER 210.84 3.1865000000000003e-24 125090000.0 2742.194 3697.3100000000004 3346.48 3958.17 3673.0 3150.01 2893.04 3109.61 1867.78 2640.82 True False 2806.0817848193196 3264.427226367215 2892.0463968988374 3266.9499135530505 3340.7777985208195 3118.323759380244 2674.8156636001345 3027.133041363181 3169.486242746196 2979.794970765121 0.9417029736441239 1.0955207517277636 0.9705521437792909 1.0963673492992696 1.1211435119856616 1.0464893692264852 0.8976509088185094 1.01588635159885 1.0636591691180577 1.0 11.540997351981584 -7.046140479869318 24.99871875951448 0.9922582705983515 1.050296783193588 0.12661239963860182 0.06481176448740304 839.473534670588 454820.4918908839 0.02489366209224768 0.01928332574343212 8.992066709305996e-08 7.046140479869318 0.058038512595236624 SAS(ph)PDDDLGSSNWEAADLGNEER ddPTM_A459_Selumetinib_30min_R2 4 SASPDDDLGSSNWEAADLGNEER 23 0 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 S(0.189)AS(0.808)PDDDLGS(0.003)SNWEAADLGNEER;S(0.428)AS(0.572)PDDDLGSSNWEAADLGNEER;S(0.205)AS(0.795)PDDDLGSSNWEAADLGNEER;S(0.2)AS(0.8)PDDDLGSSNWEAADLGNEER 171.94 9.429e-13 90187500.0 112567.0 108562.0 132684.0 145205.0 138671.0 97679.0 110185.0 110704.0 92660.0 118690.0 True False 106310.97678140434 116888.3563181515 124147.25589541598 125427.82850740338 121249.90924553075 111133.3956083221 115308.82082743554 111026.13031196609 111194.58913671756 115263.111306345 0.9223330480716613 1.0141003048884125 1.0770770846663924 1.088187079854566 1.0519402770872124 0.964171401836907 1.0003965667816224 0.963240789300595 0.9647023048092623 1.0 16.814571342581807 -6.76321863087573 24.999877041351095 0.9775731543438796 1.0355709945877491 0.254500985323844 0.04429169461608937 68.24015422076305 958814.9798891556 0.016437278089854512 0.015246755385667991 1.7249692958958876e-07 6.76321863087573 0.05799784024386956 SAS(ph)PDDDLGSSNWEAADLGNEERK ddPTM_A459_Selumetinib_30min_R1 6 SASPDDDLGSSNWEAADLGNEERK 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 S(0.082)AS(0.915)PDDDLGS(0.001)S(0.001)NWEAADLGNEERK;S(0.046)AS(0.941)PDDDLGS(0.01)S(0.003)NWEAADLGNEERK;S(0.035)AS(0.953)PDDDLGS(0.012)SNWEAADLGNEERK;S(0.117)AS(0.882)PDDDLGS(0.001)S(0.001)NWEAADLGNEERK;S(0.027)AS(0.941)PDDDLGS(0.031)S(0.001)NWEAADLGNEERK;S(0.036)AS(0.96)PDDDLGS(0.003)S(0.001)NWEAADLGNEERK 236.88 7.891699999999998e-45 371605300.0 6084.95 6511.379999999999 12763.779999999999 12771.560000000001 8856.71 8069.989999999999 7947.0 7525.98 4347.25 5487.45 True False 6226.717495748412 5749.024602541564 11030.528782424939 10541.246797873158 8055.622144279147 7988.813227564661 7347.55139183359 7326.366562571667 7376.965739422415 6191.817659789409 1.005636444397523 0.928487387455963 1.7814686072005712 1.7024478718631515 1.3010108803096 1.2902210088396515 1.1866550010911479 1.1832335777828518 1.1914055201156093 1.0 12.596147271455953 -7.224024513188199 1.7919347955389682 1.1397874001346286 1.3624117873246102 0.12985948620169552 0.25175199816104205 0.8999442696444817 5.651192504763988 0.14758120433120617 0.09445874596029458 5.970015886532268e-08 7.224024513188199 0.22262438718998157 SAS(ph)PDDDLGSSNWEAADLGNEERK ddPTM_A459_Selumetinib_30min_R2 5 SASPDDDLGSSNWEAADLGNEERK 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 S(0.062)AS(0.919)PDDDLGS(0.016)S(0.003)NWEAADLGNEERK;S(0.051)AS(0.942)PDDDLGS(0.006)SNWEAADLGNEERK;S(0.185)AS(0.815)PDDDLGS(0.001)SNWEAADLGNEERK;S(0.056)AS(0.94)PDDDLGS(0.002)S(0.002)NWEAADLGNEERK;S(0.068)AS(0.78)PDDDLGS(0.084)S(0.068)NWEAADLGNEERK 145.43 1.1067e-09 187934600.0 74159.4 100219.0 88686.7 87969.4 80480.4 49757.9 41253.0 48105.6 30785.9 84668.6 True False 70037.91743159959 107905.4750451245 82980.69427677816 75987.81596432054 70369.73264809526 56611.59906775594 43171.34624126872 48245.579331689194 36943.94022991661 82223.99752255791 0.8517941177985769 1.3123355504032865 1.0092028699287292 0.9241561861970224 0.855829621136938 0.6885045822811608 0.525045577228531 0.5867578904620049 0.4493084907454317 1.0 16.327271893336174 -6.423941402989574 1.3014407742141365 0.6044388469016413 1.0799239552949793 0.5065590970750726 0.1748865891860931 0.31070997153592356 1.081649437152336 0.06987144584501544 0.08566586340386022 3.7675462902335677e-07 6.423941402989574 0.475485108393338 SAS(ph)PDGGPR ddPTM_A459_Selumetinib_30min_R2 2 SASPDGGPR 9 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 S(0.028)AS(0.972)PDGGPR;S(0.01)AS(0.99)PDGGPR 123.96 0.005462300000000001 18486700.0 85134.0 60020.0 73754.0 66279.0 68779.0 85389.0 205164.0 608030.0 146216.0 245564.0 True False 80402.59309840419 64623.34100528219 69008.74793728368 57251.685862347695 60138.36712793859 97150.55966583418 214704.5325247534 609799.2666352146 175463.28561638534 238473.9292681047 0.3371546455630018 0.27098702656351714 0.28937648718699344 0.24007524024977336 0.2521800488317863 0.4073844045091089 0.9003270637746379 2.5570898609618946 0.7357755464293142 1.0 17.863472029256776 -7.461274110280291 4.122609350855083 1.5255382457430633 0.3022613279757502 0.554805204415344 0.45067379258125617 0.14280942089711787 4.830484002044775 0.19162091435639653 0.12039546418870566 3.457211028424086e-08 7.461274110280291 -1.223276917767313 SAS(ph)PDYNR ddPTM_A459_Selumetinib_30min_R1 1 SASPDYNR 8 0 Q14669;Q14669-2;Q14669-3;G5E9G6;F8W9P3;C9JLJ5;C9JSX9;C9JLD7 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.002)AS(0.997)PDY(0.002)NR 118.03 0.0085674 17475000.0 5984.7 11336.0 8803.4 11851.0 8587.8 8997.8 8258.8 6424.8 4008.6 6703.0 True False 6124.131865800953 10008.77585003657 7607.946633614786 9781.445320821796 7811.035006299233 8907.290301348741 7635.832066801971 6254.393433308411 6802.301423439809 7563.395342749079 0.8097066976238486 1.3233178217547288 1.0058903824072105 1.2932611449696505 1.0327418642458723 1.1776840820423378 1.0095772759151531 0.8269293286783442 0.8993713954092166 1.0 12.884818315997626 -7.5236721741973245 4.968550359920016 0.8987043184051323 1.1164419069273765 0.2752787665893516 0.14378574358555934 0.20549612909975487 14.787124081050875 0.0619468835540916 0.03714890668734658 2.9945241907141656e-08 7.5236721741973245 0.21773758852224423 SAS(ph)PDYNR ddPTM_A459_Selumetinib_30min_R2 3 SASPDYNR 8 0 Q14669;Q14669-2;Q14669-3;G5E9G6;F8W9P3;C9JLJ5;C9JSX9;C9JLD7 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.03)AS(0.927)PDY(0.044)NR;S(0.214)AS(0.764)PDY(0.022)NR;S(0.341)AS(0.624)PDY(0.035)NR 96.89 0.020712 332669000.0 408490.0 385254.0 403651.0 427887.0 428820.0 318588.0 370195.0 461087.0 346158.0 454909.0 True False 385787.76111503254 414801.7430131453 377680.5341219784 369608.0524537536 374947.79790056014 362470.6051460817 387409.80102747655 462428.6868329376 415399.2724626365 441774.59517447266 0.8732683258136903 0.938944311293693 0.8549168246599123 0.836643972946842 0.8487310089718486 0.8204876629515762 0.8769399717846484 1.0467525563580855 0.9402968776386529 1.0 18.752950931451352 -7.684055800042711 7.073921860633759 0.9946377152699573 0.8626821187079364 0.7155017881726646 0.038010316754322246 0.1184552675357871 8.93412998024018 0.018786320593787827 0.01071523995999723 2.069875385119058e-08 7.684055800042711 -0.13195559656202083 SAS(ph)PEVSEGHENQHGQESEAK ddPTM_A459_Selumetinib_30min_R1 2 SASPEVSEGHENQHGQESEAK 21 0 O60930 O60930 RNASEH1 Ribonuclease H1 1 S(0.216)AS(0.784)PEVS(0.001)EGHENQHGQESEAK;S(0.311)AS(0.687)PEVS(0.001)EGHENQHGQESEAK 111.99 5.0863e-05 12936700.0 5808.700000000001 5982.6 5856.9 6278.7 6728.4 5959.1 7224.9 5772.2 1775.69 3771.3 True False 5944.031408237341 5282.154410764719 5061.565149648823 5182.242910796034 6119.817407995505 5899.156864429889 6679.919976199637 5619.102505251961 3013.2162387336825 4255.383090572815 1.3968263918248587 1.241287634588427 1.1894499371541867 1.217808784895664 1.4381354810458957 1.3862810324876782 1.5697576067823442 1.320469246987485 0.708095176062768 1.0 12.055073300942595 -8.248156959225392 23.603150423053037 0.8540476443250027 1.3440923467486083 0.7094735940039671 0.12566725340877227 178.73795061323432 317624.00237581175 0.0915146778350871 0.034065497775867856 5.64732836717041e-09 8.248156959225392 0.49004470242360565 SAS(ph)PEVSEGHENQHGQESEAK ddPTM_A459_Selumetinib_30min_R2 3 SASPEVSEGHENQHGQESEAK 21 0 O60930 O60930 RNASEH1 Ribonuclease H1 1 S(0.455)AS(0.54)PEVS(0.005)EGHENQHGQESEAK;S(0.03)AS(0.963)PEVS(0.007)EGHENQHGQESEAK;S(0.182)AS(0.559)PEVS(0.259)EGHENQHGQESEAK 158.11 9.8062e-08 13389200.0 42937.4 33889.3 46330.0 55333.0 59156.0 38620.5 40495.3 44963.5 44195.2 51364.0 True False 40551.11120003081 36488.5003387256 43349.17824028995 47796.54994525091 51724.29441865004 43940.123313006894 42378.41168991466 45094.336340891845 53035.47491706305 49880.98786030087 0.8129572596597372 0.7315111809917854 0.8690521198516712 0.9582117755789493 1.036954090875498 0.8808992202814376 0.8495904653813535 0.904038558081192 1.0632402683282214 1.0 15.606202416630518 -5.510329949977549 3.6067624053227907 0.9472898522811886 0.7737800439263791 0.55044783423266 0.06620663617428657 0.18214758752231797 5.056714103665121 0.01914535085546131 0.039733002739682506 3.0879485095881596e-06 5.510329949977549 -0.17350980835480945 SAS(ph)PHDVDLCLVSPCEFEHR ddPTM_A459_Selumetinib_30min_R1 1 SASPHDVDLCLVSPCEFEHR 20 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 S(0.162)AS(0.838)PHDVDLCLVSPCEFEHR 231.93 2.8568e-24 27953000.0 5240.2 6397.6 4333.9 4802.3 6119.3 4701.3 6184.6 4891.7 2238.7 4298.2 True False 5362.28646434577 5648.566017836449 3745.3801844086497 3963.6684553356267 5565.81039545016 4654.009190438867 5718.090642749972 4761.956225519046 3798.9103918212586 4849.915838013438 1.1056452613705978 1.1646729977380688 0.7722567379525468 0.8172654099002211 1.1476096867136478 0.959606175835246 1.1790082207059793 0.9818636827045599 0.7832940856510453 1.0 12.243743996676459 -8.018062714826398 23.84600838451234 0.8886242584961087 1.0164455757068946 0.11491733171128715 0.14127605442956587 953.1477242744962 1258313.7852208337 0.09542929641807171 0.03773669781072299 9.592620980958597e-09 8.018062714826398 0.12782131721078593 SAS(ph)PHDVDLCLVSPCEFEHRK ddPTM_A459_Selumetinib_30min_R1 1 SASPHDVDLCLVSPCEFEHRK 21 1 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 S(0.37)AS(0.63)PHDVDLCLVSPCEFEHRK 90.453 0.00050518 3884200.0 2912.7 2515.4 2958.6 3904.7 3153.5 2683.2 2588.8 2357.8 1479.3 1901.8 True False 2980.560242872397 2220.8957986222645 2556.8383704265075 3222.81744529684 2868.266481795646 2656.209444150673 2393.5247317451635 2295.2634847862305 2510.2640562027923 2145.914555100731 1.3889463752355633 1.0349413928636193 1.1914912289256958 1.5018386625116853 1.3366172828167464 1.2377983260503065 1.1153867827849322 1.0695968669071676 1.1697875156473592 1.0 11.067376917426335 -7.224865762485322 3.1667509875595297 1.0903960791911582 1.282901397354623 0.38433650474841385 0.12132276738764781 0.3225812436113366 6.575497655211217 0.05612373548661067 0.0397412379759192 5.958462871640843e-08 7.224865762485322 0.19250531816346483 SAS(ph)PPPATSSSSSSR ddPTM_A459_Selumetinib_30min_R1 2 SASPPPATSSSSSSR 15 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 S(0.216)AS(0.784)PPPATSSSSSSR;S(0.134)AS(0.866)PPPATSSSSSSR 107.93 0.004118600000000001 1757320.0 304.42 462.36 640.86 698.39 656.51 489.34999999999997 471.53999999999996 574.16 312.85 227.63 True False 311.51239370179394 408.2266762546675 553.8347319919998 576.4292969039521 597.1287864162543 484.4275832942502 435.9713581609678 558.9314116654773 530.8836003400548 256.84852780396415 1.2128253035561534 1.589367397761534 2.156269832368695 2.2442382747231604 2.3248285342402433 1.8860438385069602 1.6973870237392075 2.1761129660516234 2.0669131525847946 1.0 8.004773994290794 -5.000235408276981 3.3227223498168534 1.9977993647536707 1.2339955064600239 0.2773216740994551 0.36534408443108674 0.27896908537802806 6.167820026549707 0.09030868882096611 0.41621913585902 9.994580992919103e-06 5.000235408276981 -0.7638038582936468 SAS(ph)PQPAFHLKPDTPVSVK ddPTM_A459_Selumetinib_30min_R2 1 SASPQPAFHLKPDTPVSVK 19 1 Q5VT82;B7ZM79;Q9HC56-2;Q9HC56 Q5VT82 PCDH9 Protocadherin-9 1 S(0.058)AS(0.942)PQPAFHLKPDTPVSVK 77.027 0.0035733000000000006 5099900.0 37765.0 16909.0 25608.0 31175.0 24836.0 21737.0 38654.0 30837.0 25518.0 20161.0 True False 35666.17248527307 18205.865928995616 23960.409159882267 26928.911220125356 21715.879643342898 24731.074441160297 40451.48759144794 30926.730564659836 30622.313032492562 19578.89954543117 1.8216637969111977 0.9298717676522347 1.2237873279999305 1.3754047390477238 1.1091470995575132 1.2631493605538935 2.066075649327671 1.5795949355017114 1.5640466902358885 1.0 14.257012058435626 -7.100670316520657 24.267996577925455 1.6098593419188911 1.2638557495266873 0.12741621985643115 0.3230725629092596 49.20890888433952 11851.298035267037 0.11694833899192658 0.0905874704209376 7.931031658754626e-08 7.100670316520657 -0.3460035923922038 SAS(ph)PSNIK ddPTM_A459_Selumetinib_30min_R2 2 SASPSNIK 8 0 E7EUC4;Q9NRH2 E7EUC4 SNRK SNF-related serine/threonine-protein kinase 1 SAS(0.795)PS(0.204)NIK;S(0.001)AS(0.943)PS(0.056)NIK 108.43 0.012879 12070300.0 118962.0 99275.0 95941.0 131206.0 112279.0 73424.0 119168.0 130375.0 88172.0 118672.0 True False 112350.56828261756 106889.07328056294 89768.26051266264 113335.51645702522 98173.50823300437 83537.48952328991 124709.54812691217 130754.36966525686 105808.86373152045 115245.63101311494 0.9748791975448691 0.9274891580783567 0.7789298364156384 0.9834257095969882 0.851863167132403 0.7248646980273236 1.0821195305245042 1.1345711634862499 0.9181160517875027 1.0 16.81435253324598 -7.289743282184945 24.98119809119088 1.0449159719455658 0.8757301228944824 0.41977057577475874 0.0918292022401243 701.8349696163647 619440.9322303178 0.03859835456677884 0.026028149727567677 5.131646334691936e-08 7.289743282184945 -0.16918584905108347 SAS(ph)PSSQGWQGR ddPTM_A459_Selumetinib_30min_R2 2 SASPSSQGWQGR 12 0 Q5VV67-2;Q5VV67;X6R7H2 Q5VV67-2 PPRC1 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 1 S(0.042)AS(0.951)PS(0.007)SQGWQGR;S(0.009)AS(0.977)PS(0.014)SQGWQGR 187.63 0.00011812 15972200.0 31708.0 27976.0 26065.0 33215.0 36892.0 24277.0 31591.0 22711.0 20465.9 36916.0 True False 29945.796297180932 30121.669242981916 24388.00627742623 28691.05970092908 32257.29714133543 27620.936385336016 33060.04409637892 22777.085249991567 24559.651865024272 35850.1391607131 0.8353048830002163 0.8402106643979554 0.680276474467697 0.8003053927436521 0.8997816437121411 0.7704554858633526 0.9221733825961896 0.6353416132607979 0.6850643383816576 1.0 15.129691098646253 -10.46684183956975 4.228755149891822 1.0000069750397962 0.7869201852575546 0.33725062956974017 0.09021413347651602 130385491.87210473 236591920.28644678 13447.531968873476 0.023177951731887726 3.41317189150764e-11 10.46684183956975 -0.2130867897822416 SAS(ph)PSVPGPTKPKPK ddPTM_A459_Selumetinib_30min_R1 1 SASPSVPGPTKPKPK 15 2 Q03164-2;Q03164;Q03164-3;A0A3B3ITZ6 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 S(0.041)AS(0.945)PS(0.014)VPGPTKPKPK 73.252 0.01709 76510000.0 10326.0 11954.0 13331.0 15313.0 12434.0 10861.0 11157.0 11369.0 6107.5 8821.5 True False 10566.575709101653 10554.420122736165 11520.72342194138 12638.872010610432 11309.346895400993 10751.748200998978 10315.41850744777 11067.457188283419 10363.98142584908 9953.825453686553 1.061559272690296 1.0603380752298777 1.1574166611164054 1.2697502150722795 1.1361809535460963 1.0801624210736889 1.0363270438530037 1.1118797732367725 1.0412058634211452 1.0 13.281035373373957 -6.843409479580295 3.908086936199185 1.057120408302254 1.1414854610650118 0.3245321876845093 0.0605696229548673 0.3240022559898318 9.522280942079675 0.024338837265696488 0.021664768162996232 1.4341366033879976e-07 6.843409479580295 0.08436505276275774 SAS(ph)PSVPGPTKPKPK ddPTM_A459_Selumetinib_30min_R2 2 SASPSVPGPTKPKPK 15 2 Q03164-2;Q03164;Q03164-3;A0A3B3ITZ6 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 S(0.028)AS(0.944)PS(0.028)VPGPTKPKPK;S(0.147)AS(0.749)PS(0.103)VPGPTKPKPK 90.453 0.0060857 154074000.0 1244830.0 1119070.0 1165330.0 1262440.0 951360.0 951250.0 1089890.0 1069780.0 902430.0 1147820.0 True False 1175647.3320493184 1204899.0706228113 1090353.9365153683 1090493.49416953 831841.6515336897 1082276.052912257 1140572.0445760654 1072892.8826883878 1082941.2160009514 1114679.454205484 1.0546954351888462 1.0809377225685333 0.9781771184546914 0.9783023182631521 0.7462608630627412 0.9709302964444398 1.023228732056461 0.9625124771435923 0.9715270268194234 1.0 20.088197466631577 -5.418501064195451 2.739662076000506 0.9448913800251916 1.0691998475065547 0.2882861258339773 0.07209217004462885 0.3590754842710241 5.152801436186993 0.02124197794535194 0.05297640075568522 3.815038594410143e-06 5.418501064195451 0.12430846748136315 SAS(ph)PTVPR ddPTM_A459_Selumetinib_30min_R1 1 SASPTVPR 8 0 K7EQ87;K7EKI0;Q92817 K7EQ87 EVPL Envoplakin 1 S(0.085)AS(0.637)PT(0.278)VPR 87.258 0.032723 24792000.0 4251.8 4922.4 4813.5 5033.8 5106.0 4279.6 4500.6 4360.7 2432.2 3724.1 True False 4350.858667437379 4346.083119638326 4159.85313866288 4154.74132612883 4644.163201537519 4236.5511095659 4161.116118546154 4245.04007045013 4127.265759140424 4202.124510805884 1.0353949903790383 1.0342585300512273 0.9899404760534102 0.9887239931717382 1.1051940963659976 1.0081926650844084 0.990241033516671 1.0102128243782134 0.9821854989130002 1.0 12.036903194997864 -6.989103432062283 24.99805886325855 0.9968974548815965 1.0293422931523097 0.22557416589879276 0.03076414229045065 377.339534438663 865660.917292083 0.011284863501867649 0.009944523925035793 1.0254076849205989e-07 6.989103432062283 0.032444838270713205 SAS(ph)PTVPR ddPTM_A459_Selumetinib_30min_R2 2 SASPTVPR 8 0 K7EQ87;K7EKI0;Q92817 K7EQ87 EVPL Envoplakin 1 S(0.014)AS(0.818)PT(0.168)VPR;S(0.003)AS(0.982)PT(0.014)VPR 111.61 0.011527 69520000.0 345090.0 290780.0 353190.0 403650.0 460560.0 276520.0 265420.0 297350.0 260970.0 349610.0 True False 325911.27930472366 313081.890994934 330466.1399241956 348672.1736649111 402700.3353413601 314608.1200013637 277762.5559197524 298215.2392710572 313171.2921110429 339515.85090413137 0.9599294950053769 0.9221421920690782 0.973345247487455 1.0269687637157336 1.1861017218164287 0.9266375020888176 0.8181136614978952 0.8783543934013962 0.9224055114866276 1.0 18.373119405274885 -6.984616445475405 24.99613187804449 0.8914089763666763 1.0120328875134794 0.30653145363427203 0.0781730737047023 286.7951446613268 466000.52350322367 0.029217934336369152 0.025759642993157757 1.0360567738254553e-07 6.984616445475405 0.12062391114680315 SAS(ph)QDCIETTPGAQEGK ddPTM_A459_Selumetinib_30min_R2 2 SASQDCIETTPGAQEGK 17 0 Q99767-2;Q99767 Q99767-2 APBA2 Amyloid beta A4 precursor protein-binding family A member 2 1 S(0.303)AS(0.587)QDCIET(0.099)T(0.011)PGAQEGK;S(0.041)AS(0.959)QDCIETTPGAQEGK 168.08 4.5003e-06 10442000.0 49257.3 39345.9 44999.2 53406.8 49076.3 37922.9 45731.7 47851.8 39885.0 41258.9 True False 46519.77645859505 42363.60401299124 42104.00046342446 46132.701708131244 42910.89644631141 43146.43524518923 47858.31466564441 47991.04081570807 47863.11448001274 40067.64835350376 1.1610308658039092 1.0573019818690386 1.0508228506937725 1.151370335017356 1.0709611921249433 1.076839720278124 1.1944378228391679 1.1977503743743283 1.194557615603794 1.0 15.290150217286756 -7.2536028283709815 24.87171238714133 1.1631656517057272 1.0925198710185031 0.11417435968959333 0.06452073891703575 841.0836941620839 2669442.271087841 0.023803089886522775 0.01807713950535943 5.576955403354711e-08 7.2536028283709815 -0.07064578068722405 SAS(ph)QDCIETTPGAQEGKK ddPTM_A459_Selumetinib_30min_R2 2 SASQDCIETTPGAQEGKK 18 1 Q99767-2;Q99767 Q99767-2 APBA2 Amyloid beta A4 precursor protein-binding family A member 2 1 S(0.167)AS(0.833)QDCIETTPGAQEGKK;S(0.199)AS(0.801)QDCIETTPGAQEGKK 134.28 0.00020232 31447000.0 87805.0 90471.0 93275.0 95324.0 87195.0 49023.0 57075.0 59917.0 43514.0 89301.0 True False 82925.14961126451 97409.83478988487 87273.78805014145 82340.70675692795 76240.78456680963 55775.47326351391 59729.10059196698 60091.34855020667 52218.01588274479 86722.64809813727 0.9562109948190762 1.1232340908185108 1.0063552020618707 0.9494717765507964 0.8791334932546555 0.6431477184644678 0.6887370473786294 0.6929141333669374 0.6021266304466825 1.0 16.404121189974184 -6.4027522407661 1.9069436495947654 0.7040616749043448 1.030340093478824 0.5848301402196607 0.11129841770119783 0.2112036841517356 1.5215085343868473 0.03800929006642137 0.04493989053903716 3.9559223582314325e-07 6.4027522407661 0.32627841857447926 SAS(ph)QS(ph)SLDKLDQELK ddPTM_A459_Selumetinib_30min_R2 1 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 2 S(0.01)AS(0.99)QS(0.593)S(0.407)LDKLDQELK 144.18 0.012861 3606700.0 28359.0 25755.0 23726.0 20773.0 20889.0 19048.0 23421.0 21356.0 17936.0 25442.0 True False 26782.92031007172 27730.32568462251 22199.494990915584 17943.68156457625 18264.7370699706 21671.689099471932 24510.12290783106 21418.14242432388 21523.70117371213 24707.42335374534 1.0840029705490015 1.1223479392244653 0.8984949451457234 0.726246574062779 0.7392408673485531 0.8771327057941383 0.9920145276547273 0.8668707423543278 0.8711430919181381 1.0 14.592656944704228 -5.315238728796995 4.9160033864755945 0.8593828936228369 1.1041285035270063 0.5454911007357006 0.08450081014098353 0.14544200873411847 7.701698217254136 0.02403845486894516 0.05372197582393718 4.83906294380112e-06 5.315238728796995 0.24474560990416938 SAS(ph)QSS(ph)LDKLDQELK ddPTM_A459_Selumetinib_30min_R2 1 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 2 S(0.007)AS(0.622)QS(0.448)S(0.922)LDKLDQELK 135.57 0.014058 7543500.0 109930.0 96033.0 80850.0 76254.0 83509.0 75294.0 85945.0 86999.0 63456.0 84119.0 True False 103820.53068465697 103398.42230523577 75648.19902282419 65868.07365451295 73017.85284006782 85665.06504912015 89941.61279678674 87252.15268654018 76148.97310878 81690.26590259031 1.2709045507142234 1.2657373698419694 0.9260368807347151 0.8063148396781549 0.8938378646867949 1.0486569495473244 1.101007712522757 1.068085061573701 0.9321670368851792 1.0 16.317876558646 -5.255471159139391 24.6952707796252 0.9730793362039308 1.2683210126363584 0.6679849004636003 0.08355730255855628 269.78565133146964 1116307.66273438 0.024982564564955102 0.06248400803469936 5.553014926541286e-06 5.255471159139391 0.2952416764324276 SAS(ph)QSSLDKLDQELK ddPTM_A459_Selumetinib_30min_R1 2 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 S(0.061)AS(0.92)QS(0.01)S(0.01)LDKLDQELK;S(0.048)AS(0.461)QS(0.453)S(0.038)LDKLDQELK 147.17 0.0015630000000000002 22820900.0 4132.78 4694.44 3790.54 4547.85 3581.7000000000003 3832.47 3948.4 4609.7300000000005 2533.94 3493.33 True False 4229.065733009985 4144.81278241405 3275.8054879458145 3753.6533712175715 3257.735867400494 3793.9188314043445 3650.569009124925 4487.46498588669 4299.911108344823 3941.7329334157266 1.0728950450088632 1.051520448601865 0.8310571881152664 0.9522850570104012 0.8264730062717588 0.9625002240110435 0.9261330158056923 1.1384497787367995 1.0908681995912686 1.0 11.944614316576462 -7.752410929777899 24.984314735268853 1.0859942456197698 0.942016440867339 0.3492116154405671 0.08107419919762486 195.79733593872658 541831.0636141393 0.04036761644532497 0.02288015326305043 1.7684348719746593e-08 7.752410929777899 -0.14397780475243072 SAS(ph)QSSLDKLDQELK ddPTM_A459_Selumetinib_30min_R2 1 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 S(0.045)AS(0.668)QS(0.216)S(0.071)LDKLDQELK 85.49600000000002 0.011361 31318000.0 41241.0 32580.0 32531.0 36245.0 35877.0 25920.0 35693.0 32884.0 24362.0 38816.0 True False 38948.990320803576 35078.78123878863 30437.990877074753 31308.368473887534 31369.81051555055 29490.24472166699 37352.795224337715 32979.686995760734 29235.080731153837 37695.281223920225 1.0332590461239957 0.930588129331391 0.8074748320954235 0.8305646610754092 0.8321946274708854 0.7823325298062352 0.9909143535089167 0.8749022669403212 0.7755634069285624 1.0 15.202096314689642 -4.9162651979786895 3.2365436977857214 0.8570479617105642 1.0364353154864032 0.33604763005779503 0.07417954689865525 0.3016179688330053 5.627376204781534 0.018695705917698854 0.1148959322249276 1.2126481317697924e-05 4.9162651979786895 0.17938735377583903 SAS(ph)SDTSEELNSQDSPPK ddPTM_A459_Selumetinib_30min_R1 2 SASSDTSEELNSQDSPPK 18 0 J3QRP6;O14745;O14745-2 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 S(0.003)AS(0.618)S(0.059)DT(0.32)SEELNSQDSPPK;S(0.007)AS(0.934)S(0.057)DT(0.002)SEELNSQDSPPK 417.4 0.0 72029000.0 8026.0 11689.5 5744.1 6536.2 8444.3 7382.3 10446.4 9948.599999999999 4321.299999999999 10313.3 True False 8212.990184122582 10320.88790569888 4964.082770082774 5394.775369669686 7680.514555962252 7308.040764592104 9658.419637555106 9684.730810392866 7332.930484735425 11637.112515049086 0.7057584236211142 0.8868942267552997 0.42657341017054135 0.4635836735868263 0.6600017440778225 0.6279943375249971 0.8299670236121598 0.8322279945191383 0.6301331602021117 1.0 13.506445510218676 -7.256489040861177 22.885375611931426 0.8091010561176905 0.6249759071153533 0.29889217790325284 0.14533275894565045 187.99687340451277 869113.9912092272 0.059638230133467675 0.04460439255717937 5.5400152363038316e-08 7.256489040861177 -0.18412514900233712 SAS(ph)SDTSEELNSQDSPPK ddPTM_A459_Selumetinib_30min_R2 2 SASSDTSEELNSQDSPPK 18 0 J3QRP6;O14745;O14745-2 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 SAS(0.466)S(0.466)DT(0.069)SEELNSQDSPPK;S(0.002)AS(0.462)S(0.462)DT(0.073)SEELNSQDSPPK 354.93 4.458399999999997e-184 76245000.0 105223.5 66306.2 83309.0 92419.6 93142.5 73073.5 107070.5 115709.0 99023.7 76590.2 True False 99375.5991130445 71391.67233196327 77948.98963998101 79831.89104729732 81441.10644548498 83138.71132981214 112049.49040617076 116045.69403334399 118831.20695335166 74378.84192076192 1.3360734927671019 0.959838449864802 1.0479995066745256 1.0733145204431216 1.0949499123991029 1.1177736730343608 1.5064699518384617 1.5601976454133428 1.5976479854304027 1.0 16.18260466489945 -7.242015183086558 8.656534418836886 1.4628525347333499 1.0935853095766204 0.40774737884766166 0.17987009561478062 0.21321254239123408 86.79830280968845 0.06621811414219453 0.05001759996044745 5.7277600618684885e-08 7.242015183086558 -0.3692672251567295 SAS(ph)SGAEGDVSSER ddPTM_A459_Selumetinib_30min_R2 1 SASSGAEGDVSSER 14 0 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 S(0.001)AS(0.5)S(0.5)GAEGDVSSER 233.52 1.1644e-13 14526000.0 23267.0 19016.0 19811.0 22612.0 25875.0 19218.0 19511.0 26206.0 26419.0 20592.0 True False 21973.91328518067 20474.466053922806 18536.381828585894 19532.206592124294 22624.35117456507 21865.105056365577 20418.300160313054 26282.255121363145 31703.53820853595 19997.455455558673 1.0988354660428863 1.023853564740985 0.9269370230517681 0.9767345968356662 1.131361498708887 1.093394362345623 1.0210449127235035 1.3142799682575361 1.5853786137437476 1.0 14.287528817789834 -7.78249884188591 6.688764762154962 1.3403673518740353 1.0369762871806858 0.398961043707459 0.14436670309266497 0.14155937005406324 23.615244099246965 0.07409968380174006 0.036804335683639236 1.65006540147156e-08 7.78249884188591 -0.30339106469334953 SAS(ph)SGAEGDVSSEREP ddPTM_A459_Selumetinib_30min_R1 2 SASSGAEGDVSSEREP 16 1 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 S(0.003)AS(0.927)S(0.07)GAEGDVSSEREP;S(0.009)AS(0.901)S(0.09)GAEGDVSSEREP 258.42 2.6964e-38 343740000.0 4513.76 5107.8099999999995 5065.6 5627.6 5587.099999999999 4073.47 4877.0 4524.5 3026.58 3666.94 True False 4618.921825751953 4509.785230643551 4377.719343349054 4644.8453031353265 5081.74779148262 4032.494590214836 4509.123963504775 4404.495562352744 5135.885207342826 4137.627468020335 1.1163213366721716 1.089944724482718 1.058026460135521 1.1225866366741015 1.2281791511583335 0.9745910238130258 1.0897849065329663 1.0644978544818327 1.241263319870629 1.0 12.014588042418344 -11.267649654888766 2.6737949676926376 0.9781082328811755 1.1053881468546605 0.16090324012414214 0.07447147831655197 25151914.30148467 18948827.59335039 3633240.5805397723 0.019350121648584823 5.399460210213276e-12 11.267649654888766 0.12727991397348493 SAS(ph)SGAEGDVSSEREP ddPTM_A459_Selumetinib_30min_R2 1 SASSGAEGDVSSEREP 16 1 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 S(0.001)AS(0.607)S(0.392)GAEGDVSSEREP 176.29 5.778e-06 305140000.0 58723.0 65921.0 61932.0 70340.0 74411.0 54276.0 55566.0 59084.0 48775.0 60129.0 True False 55459.41074679437 70976.9287305765 57947.36254646315 60759.57065673189 65062.82493721977 61752.02633152761 58149.929101940186 59255.92465811725 58531.3628873667 58392.91953609592 0.9497625942904228 1.2155057375869296 0.992369674385653 1.0405297618176637 1.1142245576024128 1.057525926467082 0.9958387003752137 1.014779276817763 1.0023708927789643 1.0 15.83350582452039 -7.200414199625039 5.362955689295688 1.004486738979856 1.0674680161340713 0.15262674444786128 0.06676433770897239 0.3872047946176592 23.114338446070093 0.02485706107083702 0.018930176295956787 6.303558684748201e-08 7.200414199625039 0.06298127715421531 SAS(ph)SSWLEGTSTQAK ddPTM_A459_Selumetinib_30min_R1 2 SASSSWLEGTSTQAK 15 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 S(0.017)AS(0.863)S(0.119)S(0.002)WLEGTSTQAK;S(0.045)AS(0.861)S(0.093)S(0.002)WLEGTSTQAK 187.08 2.3279e-05 29219000.0 4983.4 5080.4 5145.1 4941.9 5188.9 5168.700000000001 4873.3 4624.3 2637.3 4145.8 True False 5099.503523991587 4485.584406186118 4446.423680011293 4078.889935952175 4719.564911174701 5116.707570804115 4505.703057483663 4501.6485421566595 4475.3054792291105 4677.953813511728 1.09011412409893 0.9588774462095001 0.9505061095661768 0.8719389071715017 1.0088951493156653 1.0937918104332491 0.9631781836899417 0.9623114553106892 0.9566801335880463 1.0 12.191661902370699 -4.757082452428582 24.95741887177076 0.9734112213446089 1.0901143007255367 0.3022266808106333 0.052913056926428385 179.76956165204004 1029623.1386872773 0.014262564241371433 0.10950313775687881 1.7495145052328846e-05 4.757082452428582 0.11670307938092783 SAS(ph)SSWLEGTSTQAK ddPTM_A459_Selumetinib_30min_R2 3 SASSSWLEGTSTQAK 15 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 S(0.026)AS(0.325)S(0.325)S(0.325)WLEGTSTQAK;S(0.007)AS(0.938)S(0.056)SWLEGTSTQAK;S(0.001)AS(0.945)S(0.027)S(0.027)WLEGTSTQAK 312.78 1.0140999999999995e-94 63240000.0 141928.0 120370.0 144424.0 166894.0 149161.0 113183.0 124112.0 129384.0 104061.0 119035.0 True False 134040.20994279993 129601.99194944702 135131.9170769617 144162.74929179155 130422.06166374103 128772.93087702287 129883.45392326236 129760.48601932586 124876.10770727386 115598.15025992726 1.1595359410285107 1.1211424374700767 1.1689799254842048 1.247102561482477 1.1282365796553109 1.1139705141256289 1.1235772685913572 1.1225135153767944 1.0802604317325555 1.0 16.818758787221938 -8.550329838895484 0.5056188311646496 0.9957841551285589 1.1672699926819579 0.6811731024175045 0.033781961571684956 0.6941881055371888 0.43011194886264736 0.04391317380790922 0.020569027345576515 2.816243232444399e-09 8.550329838895484 0.17148583755339897 SAS(ph)TAGDIACAFRPVK ddPTM_A459_Selumetinib_30min_R1 1 SASTAGDIACAFRPVK 16 1 B7ZM87;O75044 B7ZM87 SRGAP2 SLIT-ROBO Rho GTPase-activating protein 2 1 S(0.031)AS(0.794)T(0.174)AGDIACAFRPVK 73.76 0.018613 12382000.0 1634.1 2053.2 2145.1 2905.6 1951.1 2082.7 1951.9 1983.3 1060.3 1863.1 True False 1672.1713505949056 1812.8103894932167 1853.8072021908679 2398.191504867084 1774.623349494682 2061.7499289402995 1804.6666115162934 1930.6964413336723 1799.2516587519913 2102.2470331308064 0.7954209587369933 0.8623203462408786 0.8818217711693257 1.1407753071224638 0.8441554781750814 0.9807362771585431 0.8584465018027228 0.9183965589706888 0.8558707090062703 1.0 11.037716493701566 -5.19063726635148 2.686180307356507 0.936232390080863 0.8116315077654837 0.22156531562940196 0.08481291846061395 0.45143102698433546 6.152276514147227 0.022529613403622636 0.08128705732175272 6.447075165982225e-06 5.19063726635148 -0.12460088231537936 SAS(ph)TDLGTADVVLGR ddPTM_A459_Selumetinib_30min_R1 1 SASTDLGTADVVLGR 15 0 A0A0U1RRA6;B5MCU0;B5MCG9;Q9Y2K5;H7C0E9;Q9Y2K5-2;Q9Y2K5-3 A0A0U1RRA6;Q9Y2K5-3 R3HDM2 R3H domain-containing protein 2 1 S(0.013)AS(0.493)T(0.493)DLGT(0.001)ADVVLGR 222.88 1.1757999999999998e-09 7437600.0 3189.2 3384.9 3025.5 3571.5 2817.6 2752.2 2822.6 2800.6 1449.0 2530.1 True False 3263.502154897052 2988.5943344026814 2614.6537178819035 2947.804570358202 2562.7485774876836 2724.515366797663 2609.689009511704 2726.318990369121 2458.847169227233 2854.8629802609935 1.1431379290219739 1.046843352926683 0.9158596177680198 1.0325555344476502 0.897678310730484 0.9543419020931736 0.9141205821629746 0.954973674470317 0.8612837765693552 1.0 11.479205789465027 -2.657998819733532 0.7030265140752756 0.9313321995176709 5.603921188174769 0.641710850130681 0.04797024289090465 28.967023613825543 0.857879912730485 0.017587895994988074 193.75190176285489 0.0021978658458375404 2.657998819733532 4.672588988657098 SAS(ph)TDLGTADVVLGR ddPTM_A459_Selumetinib_30min_R2 3 SASTDLGTADVVLGR 15 0 A0A0U1RRA6;B5MCU0;B5MCG9;Q9Y2K5;H7C0E9;Q9Y2K5-2;Q9Y2K5-3 A0A0U1RRA6;Q9Y2K5-3 R3HDM2 R3H domain-containing protein 2 1 SAS(0.774)T(0.226)DLGTADVVLGR;SAS(0.948)T(0.052)DLGTADVVLGR;S(0.005)AS(0.954)T(0.04)DLGT(0.002)ADVVLGR 196.37 3.1676e-05 14516000.0 109910.0 97869.0 113945.0 114999.0 112027.0 65209.0 66601.0 72369.0 56053.0 103074.0 True False 103801.64220459061 105375.2376015653 106613.90275393557 99335.93781565981 97953.16672591293 74190.94784163497 69698.07846737778 72579.58180866712 67265.1662516774 100097.98580158583 1.0370003089807038 1.052720859043458 1.065095385288427 0.9923869798195885 0.9785728048521939 0.7411832240930025 0.6962985109963479 0.725085337406632 0.6719932045886554 1.0 16.611053418607725 -6.689220448998099 3.5078986753467074 0.7433188993011695 1.0352451073086208 0.6830344932115358 0.08779868579948541 0.1227689205620107 3.0130105010080666 0.029225125821426147 0.02842811075939779 2.045406119753063e-07 6.689220448998099 0.2919262080074514 SAS(ph)TEKLEQGTSALIR ddPTM_A459_Selumetinib_30min_R2 2 SASTEKLEQGTSALIR 16 1 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 SAS(0.841)T(0.159)EKLEQGTSALIR;S(0.129)AS(0.848)T(0.023)EKLEQGTSALIR 93.812 0.041399 15441300.0 73832.0 88237.0 81242.0 87001.0 83095.0 63912.0 52639.0 57793.0 50982.0 87024.0 True False 69728.71301291356 95004.49417332716 76014.97816960145 75151.31371490397 72655.86322127463 72715.29786462891 55086.81780219969 57961.16806185382 61179.82455609901 84511.39100449403 0.8250806451547534 1.1241619980941402 0.899464288376927 0.8892447848942361 0.8597168069025279 0.8604200806582649 0.6518271341584042 0.6858385286638063 0.7239240039587761 1.0 16.36685819003445 -6.509654059904035 1.2038158882749266 0.7467455941676727 0.9614611154723731 0.27158044083530886 0.11594499225932249 0.4940089217550393 1.499414834122137 0.05082711398500165 0.05826151868962912 3.092758008112221e-07 6.509654059904035 0.2147155213047004 SAS(ph)TLCLPSVGAAR ddPTM_A459_Selumetinib_30min_R1 2 SASTLCLPSVGAAR 14 0 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.206)AS(0.376)T(0.376)LCLPS(0.042)VGAAR;S(0.043)AS(0.727)T(0.23)LCLPSVGAAR 211.82 3.2836e-06 52030000.0 1855.18 2175.1 1694.99 1890.23 2158.45 2299.44 1979.3 2079.07 1104.63 2065.48 True False 1898.4020844481115 1920.4382808234443 1464.8196679136163 1560.136814511601 1963.2185786052996 2276.309721324474 1829.9998074564282 2023.9263098288693 1874.4764310168923 2330.6044774789452 0.8145535215403197 0.8240086635810532 0.6285149119331208 0.6694129482662059 0.8423645442957987 0.9767035733951723 0.7852039353481249 0.8684126068521867 0.8042876640503779 1.0 11.186488472828465 -6.422922606353425 6.048041475987171 0.8761605603111633 0.733942704451015 0.42863063136184243 0.08302003827034678 0.2528557651993148 12.74965899238151 0.02683293749714545 0.030354296892341672 3.7763948234588216e-07 6.422922606353425 -0.14221785586014835 SAS(ph)TLCLPSVGAAR ddPTM_A459_Selumetinib_30min_R2 3 SASTLCLPSVGAAR 14 0 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.002)AS(0.499)T(0.499)LCLPS(0.001)VGAAR;S(0.002)AS(0.96)T(0.038)LCLPSVGAAR;S(0.323)AS(0.339)T(0.339)LCLPSVGAAR 183.28 7.6904e-05 45650200.0 86145.0 52929.4 84510.7 86472.0 78683.3 92498.8 79965.0 79781.0 74806.4 65404.1 True False 81357.40576575791 56988.914785154666 79073.37357029284 74694.36442747977 68798.40041637313 105239.67007949577 83683.53094764153 80013.14950154453 89769.770265454 63515.7136927402 1.2809020167722212 0.8972411939011 1.2449419044996242 1.1759981913895627 1.0831713353515657 1.6569076211376113 1.317524846724764 1.2597378640600865 1.4133474229655805 1.0 15.954825936191556 SAS(ph)TLCLPSVGAARPQVK ddPTM_A459_Selumetinib_30min_R1 2 SASTLCLPSVGAARPQVK 18 1 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.006)AS(0.989)T(0.006)LCLPSVGAARPQVK;SAS(0.5)T(0.5)LCLPSVGAARPQVK 168.62 6.114e-08 823380000.0 6210.6 6625.5 7379.599999999999 8109.700000000001 7034.4 6493.4 6925.0 6569.8 3928.7 5769.8 True False 6355.294896276074 5849.783379888614 6377.490853241209 6693.493132922839 6398.139762024189 6428.082291535478 6402.641674650511 6395.54756228203 6666.716959104915 6510.410032611309 0.9761742907807268 0.8985276427423851 0.9795835932446199 1.0281215928634984 0.9827552688655942 0.987354446085048 0.9834467633496238 0.9823571065794748 1.0240087683741343 1.0 12.668532693396509 -5.50649317292525 24.05451445154208 0.9964519473757665 0.9377771092996057 0.5155747983561043 0.02329798394286309 313.6914617382178 460507.1513484792 0.005824940621873903 0.011607902661866712 3.115349868641248e-06 5.50649317292525 -0.05867483807616081 SAS(ph)TLCLPSVGAARPQVK ddPTM_A459_Selumetinib_30min_R2 1 SASTLCLPSVGAARPQVK 18 1 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.013)AS(0.827)T(0.16)LCLPSVGAARPQVK 95.429 0.0022016 218150000.0 36329.0 36699.0 42084.0 47779.0 36003.0 35910.0 28085.0 29868.0 26617.0 36396.0 True False 34309.9796165096 39513.69529411615 39376.36125759473 41271.41777662774 31479.981269096264 40856.27654147612 29391.008149371733 29954.91093508641 31941.14374111822 35345.15291183536 0.9707124397535388 1.1179381623465816 1.1140526497597787 1.1676683894839783 0.8906449307948859 1.1559230382561272 0.8315428206714626 0.8474969965416667 0.9036923343008851 1.0 15.10922476291446 -7.267914304798136 24.9807951047527 0.8829744487192045 1.07005104460408 0.46941896425492124 0.09011951057229003 436.31815927690616 1683343.125982565 0.036195412945551626 0.02505347787561661 5.3961708952158646e-08 7.267914304798136 0.18707659588487557 SAS(ph)VNKEPVSLPGIMR ddPTM_A459_Selumetinib_30min_R1 2 SASVNKEPVSLPGIMR 16 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.017)AS(0.543)VNKEPVS(0.44)LPGIMR;SAS(1)VNKEPVSLPGIMR 178.02 5.3796e-06 63610000.0 1608.83 2048.3 2262.96 2429.8 1997.92 2006.67 1997.3 1705.8000000000002 1091.79 1371.4699999999998 True False 1646.3126087617668 1808.4840837711643 1955.6624615495055 2005.4810429949205 1817.2084887614242 1986.4847217105823 1846.6420529645445 1660.5566427807078 1852.6878888133874 1547.511533749079 1.0638451299767229 1.1686401324517692 1.2637466144188403 1.2959393188730177 1.1742778319454354 1.283663920034266 1.193297763985498 1.0730496067824193 1.197204575480593 1.0 10.595734446683592 -8.804357034800177 0.7308886036690629 1.0020610488683057 1.2099767027887798 0.37798450582965015 0.07416155619372028 1.1785129419610856 1.2466299005069346 0.07870964175473542 0.02841782564315402 1.5690723348696638e-09 8.804357034800177 0.20791565392047406 SAS(ph)VNKEPVSLPGIMR ddPTM_A459_Selumetinib_30min_R2 2 SASVNKEPVSLPGIMR 16 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.067)AS(0.933)VNKEPVSLPGIMR;S(0.005)AS(0.995)VNKEPVSLPGIMR 179.09 5.1313e-06 60272000.0 103679.0 100462.0 91553.0 100099.0 91749.0 65189.0 76730.0 88790.0 63273.0 98112.0 True False 97916.93623992126 108167.11236375643 85662.57965536954 86465.34351959362 80222.67037353311 74168.19302317704 80298.0970376105 89048.36420002428 75929.36799533278 95279.25163441012 1.0276837250530895 1.1352640843443806 0.8990685609502886 0.9074939405628858 0.8419741863774325 0.7784296344786905 0.8427658242501437 0.93460394233265 0.7969139838196512 1.0 16.53987446122791 -5.363193095589 4.665516710405397 0.8654794246678359 1.0805037993389808 0.6059268313119281 0.06651200083678412 0.12977857361773804 4.544136522882107 0.017191490892053914 0.037678211899291054 4.333181740467427e-06 5.363193095589 0.21502437467114488 SAS(ph)VSSISLTK ddPTM_A459_Selumetinib_30min_R1 1 SASVSSISLTK 11 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 S(0.001)AS(0.795)VS(0.202)S(0.002)ISLTK 89.189 0.029588 16520000.0 1025.2 903.71 1196.1 1324.0 934.99 1115.9 1130.2 1356.7 826.66 869.52 True False 1049.0851653080576 797.9032130766194 1033.6761897070048 1092.7882545581012 850.4203195858917 1104.6750591561336 1044.9481040707592 1320.7159088173212 1402.7816431424321 981.1313618420372 1.069260657755797 0.813248097154479 1.053555344277566 1.1138042234287897 0.8667751869528046 1.1259196292351186 1.0650440345815757 1.3461152707805881 1.4297592531429864 1.0 9.938302498890588 SAS(ph)VSSISLTK ddPTM_A459_Selumetinib_30min_R2 4 SASVSSISLTK 11 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 S(0.001)AS(0.996)VS(0.002)SISLTK;S(0.011)AS(0.945)VS(0.042)S(0.002)IS(0.001)LTK;SAS(0.492)VS(0.492)S(0.015)ISLTK;SAS(0.927)VS(0.069)S(0.004)ISLTK 158.01 0.00056772 20836400.0 149749.0 115314.0 147327.0 167112.0 140058.0 88726.1 102902.7 102441.0 78629.0 166691.0 True False 141426.5500727434 124158.2130070496 137848.14121750908 144351.05731572074 122462.66190559349 100947.31489965662 107687.87944783185 102739.08634997955 94356.99707782199 161878.19771476963 0.8736602709275146 0.7669853924727846 0.8515547069556478 0.8917263680564826 0.7565111524244509 0.623600437395074 0.6652401680279302 0.6346690771230753 0.5828888535322069 1.0 17.304549166273375 -6.517811361670609 5.145978573228025 0.6767214099184868 0.8397237763957952 0.2538011684560916 0.112879161483798 0.2095474840024928 16.902655868517414 0.03464774929844429 0.03675146860471659 3.035209258678469e-07 6.517811361670609 0.16300236647730837 SAS(ph)WGSADQLK ddPTM_A459_Selumetinib_30min_R1 1 SASWGSADQLK 11 0 Q86VQ1;H7C0Q2 Q86VQ1 GLCCI1 Glucocorticoid-induced transcript 1 protein 1 SAS(1)WGSADQLK 155.47 0.00053471 6589100.0 2307.3 2591.0 2332.7 2620.0 1948.8 2366.4 2123.7 1902.8 1565.2 2047.9 True False 2361.0556007757345 2287.644515476778 2015.932152603904 2162.466183491106 1772.5313840885858 2342.59616451929 1963.5075991993203 1852.3315628345229 2656.030082315021 2310.7679132352414 1.0217623272560015 0.9899931976612533 0.872407887030703 0.9358214518668376 0.7670746049121455 1.013773884907155 0.8497208170292915 0.8016086566829316 1.149414472609838 1.0 11.174156651677192 -8.26766100391038 24.99927881009491 1.074707236617127 0.9061760105170122 0.365357734899711 0.08866512267321888 579.5128200865306 2328520.4771266803 0.07765863624022398 0.022009420725840115 5.399319112887565e-09 8.26766100391038 -0.16853122610011484 SAS(ph)WGSADQLK ddPTM_A459_Selumetinib_30min_R2 1 SASWGSADQLK 11 0 Q86VQ1;H7C0Q2 Q86VQ1 GLCCI1 Glucocorticoid-induced transcript 1 protein 1 S(0.005)AS(0.995)WGSADQLK 121.04 0.0045559 9971600.0 75879.0 67511.0 67595.0 69445.0 63775.0 50469.0 53082.0 60772.0 49812.0 77989.0 True False 71661.94894770384 72688.87661792095 63246.0112918713 59986.471200693086 55763.01434426612 57420.64663803281 55550.41817998754 60948.8364586538 59775.79186356762 75737.25493024323 0.94619152771918 0.9597506099854035 0.835071344348606 0.7920338709917967 0.7362692824769776 0.7581558995096841 0.7334622601670934 0.8047405007587072 0.7892521575890663 1.0 16.20871551175285 -5.388511112824925 2.800603555354225 0.7868700010501178 0.9564932631322558 0.39095023237760274 0.07235858354150779 0.23116504514988573 3.443813333484968 0.01869044831179975 0.04771474175453996 4.087792920407877e-06 5.388511112824925 0.16962326208213796 SAS(ph)WGSTDQLK ddPTM_A459_Selumetinib_30min_R1 2 SASWGSTDQLK 11 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 S(0.039)AS(0.96)WGS(0.001)TDQLK;S(0.209)AS(0.722)WGS(0.035)T(0.035)DQLK 188.15 1.9433e-05 65647000.0 4133.0 5290.6 4750.7 4906.6 5141.700000000001 4273.3 4878.6 4570.4 2435.6000000000004 4415.0 True False 4229.2908585819405 4671.1740924667865 4105.5810337271705 4049.754418289108 4676.634142840866 4230.31448184596 4510.603274216606 4449.178145248534 4133.035310814252 4981.708255741785 0.8489639781107959 0.9376651246252558 0.8241311660503576 0.8129248463358865 0.9387611443224724 0.8491694544677945 0.9054330447829425 0.8931029110587776 0.8296421826891658 1.0 12.282424820026698 -10.978267464869827 2.929015885776776 1.0032252228562235 0.8729579186806634 0.44015557955462936 0.04356996328017658 13814487.610561255 16331604.407180877 366634.9425365117 0.010477650615093122 1.0513142113844854e-11 10.978267464869827 -0.1302673041755601 SAS(ph)WGSTDQLK ddPTM_A459_Selumetinib_30min_R2 1 SASWGSTDQLK 11 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 S(0.019)AS(0.972)WGS(0.004)T(0.004)DQLK 134.99 0.0015346 2089800.0 11549.0 10870.0 12663.0 15064.0 14819.0 10767.0 9450.8 10798.0 7931.2 11133.0 True False 10907.15281431004 11703.69404744115 11848.276366431946 13012.25721315056 12957.30473645912 12250.056516905415 9890.28092640493 10829.420392294864 9517.661616243626 10811.561362992174 1.008841595409621 1.0825165445115756 1.0958894805877377 1.2035502344454463 1.1984674832269644 1.1330515644888435 0.9147874755869422 1.0016518455293444 0.8803225821593587 1.0 13.400287265987815 -7.256155117643058 24.87873448786445 0.949328126577944 1.1248806632838564 0.6427318363750266 0.06247494994238631 276.7953559972819 1303178.9314153283 0.026086191954701594 0.01959229629687653 5.5442765179284314e-08 7.256155117643058 0.17555253670591242 SASAPT(ph)LAETEKETAEHLDLAGASSR ddPTM_A459_Selumetinib_30min_R2 2 SASAPTLAETEKETAEHLDLAGASSR 26 1 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.024)AS(0.238)APT(0.713)LAET(0.018)EKET(0.007)AEHLDLAGASSR;S(0.004)AS(0.167)APT(0.662)LAET(0.167)EKET(0.001)AEHLDLAGASSR 80.868 0.00018945 10210900.0 14348.5 12877.9 11938.5 14574.9 12823.1 13612.199999999999 13480.9 13890.6 14728.599999999999 14580.0 True False 13551.067811596467 13865.593521025055 11170.389907655985 12589.773476895121 11212.1475380315 15487.156990751348 14107.788561896581 13931.01934628737 17674.731551468358 14159.037516610608 0.9570613677447423 0.9792751452744369 0.7889229684257489 0.8891687349599496 0.7918721540837802 1.0938001239549413 0.9963804775109958 0.983895927243943 1.248300354507383 1.0 13.789435578783433 -6.7727120950154545 24.999296015262818 1.0592129675613577 0.8820148824560404 0.5053279016143337 0.09056027608153035 195.53953629031176 433641.9045704055 0.031995171748775704 0.02846674061103216 1.6876714554539537e-07 6.7727120950154545 -0.17719808510531732 SASAPTLAET(ph)EKETAEHLDLAGASSRPK ddPTM_A459_Selumetinib_30min_R2 1 SASAPTLAETEKETAEHLDLAGASSRPK 28 2 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.032)AS(0.084)APT(0.072)LAET(0.749)EKET(0.063)AEHLDLAGASSRPK 55.718 0.010337 14536000.0 10263.0 12366.0 9879.4 10871.0 11489.0 11225.0 9836.6 11578.0 7992.9 11000.0 True False 9692.623546044151 13314.432437042975 9243.770159877415 9390.351046479002 10045.64910703683 12771.14185959536 10294.02139085312 11611.690063158921 9591.703340285674 10682.401418567664 0.9073450028939067 1.2463894507746576 0.8653269801123851 0.8790486968741992 0.9403923999313432 1.1955309821438784 0.9636430038062903 1.086992484945942 0.8978976696769522 1.0 13.382948382868516 SASEPS(ph)LHR ddPTM_A459_Selumetinib_30min_R1 1 SASEPSLHR 9 0 H7C155;P04049;P04049-2;P10398;Q96II5 H7C155;P10398 RAF1;ARAF RAF proto-oncogene serine/threonine-protein kinase;Serine/threonine-protein kinase A-Raf 1 S(0.005)AS(0.279)EPS(0.717)LHR 92.239 0.026157 6802900.0 1032.6 1221.0 1217.6 1334.0 1561.2 1168.1 1448.8 1101.1 528.43 713.45 True False 1056.6575709101644 1078.0447523725002 1052.2566077980518 1101.04194228135 1419.9897356522463 1156.3499745499407 1339.515849564429 1071.8952511231303 896.7071149998253 805.0282570915009 1.3125720266364052 1.3391390213647714 1.3071051836115246 1.3677059563838436 1.763900488142552 1.4364091749123633 1.6639364367208507 1.3315001575171999 1.1138827824995265 1.0 9.652895613561364 -8.248294861651065 2.7977534182954997 1.019693325745589 1.454959138130751 0.5451906426588228 0.144287301346056 0.21734871552476093 3.147121756436991 0.14019948007355468 0.04067708226684391 5.64553544397641e-09 8.248294861651065 0.43526581238516204 SASLS(ph)HPGGEGEPAR ddPTM_A459_Selumetinib_30min_R1 1 SASLSHPGGEGEPAR 15 0 C9JXU1;A6NN40;Q2M3G4-2;Q2M3G4 C9JXU1 SHROOM1 Protein Shroom1 1 S(0.005)AS(0.1)LS(0.895)HPGGEGEPAR 153.14 0.00021343 7277500.0 1749.3 1962.6 2272.9 2121.6 1897.0 2001.3 2043.8 1836.8 1127.4 1456.7 True False 1790.0552864547258 1732.817879612014 1964.2526641460183 1751.1023873644028 1725.4166849425528 1981.1687390350114 1889.63452052718 1788.0820972327379 1913.1154579618917 1643.6816344595825 1.0890523133716639 1.0542296289522868 1.1950323121982407 1.0653537465241185 1.0497268137389901 1.2053238884587218 1.1496353557229244 1.0878518441441563 1.1639209308260567 1.0 10.682715174396446 SASNGSKT(ph)DTEEEEEQQQQQK ddPTM_A459_Selumetinib_30min_R2 1 SASNGSKTDTEEEEEQQQQQK 21 1 Q9UGU0-2;Q9UGU0;A9JX13 Q9UGU0-2 TCF20 Transcription factor 20 1 S(0.004)AS(0.028)NGS(0.156)KT(0.796)DT(0.017)EEEEEQQQQQK 87.80799999999998 0.0012857 8566000.0 11855.0 8094.4 9491.5 7896.4 7578.9 6344.0 7931.2 7396.0 5869.0 7839.1 True False 11196.146559325096 8715.214452401802 8880.827223563825 6820.896697950217 6626.770825774339 7217.828414901828 8300.01651537465 7417.521135526287 7042.963993561362 7612.764814572162 1.4707070075110837 1.1448159328026735 1.1665705482670856 0.8959815341850346 0.8704814856607078 0.948121817855931 1.0902762291417394 0.9743531182426463 0.9251519211627158 1.0 12.89420479356284 -4.5313128291928635 1.0289876186438685 0.963000093595421 1.9397911636958094 0.805717572857527 0.07523113329260145 1.274458101653316 0.7791590516134264 0.02580608294560163 1.547705235834936 2.9423014839480874e-05 4.5313128291928635 0.9767910701003883 SASPDDDLGSS(ph)NWEAADLGNEERK ddPTM_A459_Selumetinib_30min_R1 1 SASPDDDLGSSNWEAADLGNEERK 24 1 O00193;E9PM92;E9PQA1 O00193 SMAP;C11orf58 Small acidic protein 1 S(0.007)AS(0.147)PDDDLGS(0.147)S(0.699)NWEAADLGNEERK 90.01700000000002 3.0021e-05 12148000.0 904.58 1140.5 1458.9 1063.5 1247.7 953.78 888.26 1067.2 553.55 848.62 True False 925.654953993721 1006.9697297959351 1260.789393164074 877.7796893674781 1134.8457552993264 944.1858391629515 821.2578330577708 1038.8943892458503 939.333920307615 957.5486432587974 0.9666923560598097 1.0516120897722172 1.316684433777971 0.9166946196907095 1.1851572902209322 0.9860447777876133 0.85766695910383 1.0849520769098595 0.9809777570263243 1.0 9.903201967262149 -6.901728228495793 11.679982915764304 0.9785549771235227 1.0885850344225871 0.17224259838222145 0.11555410964426868 0.7965107684076714 88.99666288814547 0.0400886245131388 0.03535796221895994 1.2539256072986217e-07 6.901728228495793 0.11003005729906445 SASPS(ph)VGEERPR ddPTM_A459_Selumetinib_30min_R1 1 SASPSVGEERPR 12 1 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 SAS(0.318)PS(0.682)VGEERPR 117.27 0.022824 3277200.0 1847.7 2142.3 2295.8 2309.7 2135.6 1822.3 2331.9 1806.1 918.2 1727.5 True False 1890.7478150016584 1891.4785200717488 1984.042969926714 1906.354253438707 1942.4353570708022 1803.969316516016 2156.002905576539 1758.1963609603915 1558.118337325358 1949.241452274955 0.9699915897001734 0.9703664560715188 1.0178538772665349 0.9779980059493428 0.9965083365140787 0.9254724777223509 1.10607277670002 0.9019900325372235 0.799345989439575 1.0 10.92869709276649 -7.972567549930808 24.99936722172275 0.8833379033545508 0.9924661929768477 0.31268069490902095 0.06318465651053588 200.27114112827797 182508.30822423127 0.03207765797760986 0.015409083317904982 1.0652031696521664e-08 7.972567549930808 0.10912828962229693 SASQS(ph)S(ph)LDKLDQELK ddPTM_A459_Selumetinib_30min_R1 1 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 2 SAS(0.006)QS(0.997)S(0.997)LDKLDQELK 86.944 0.037813 28211000.0 7850.2 10642.0 8838.7 9264.5 6384.7 9749.8 9537.0 10359.0 6956.5 10197.0 True False 8033.094386169836 9396.029692668419 7638.453087503809 7646.628991203576 5807.205012310338 9651.725864110107 8817.61641171725 10084.245669225784 11804.672417342474 11505.884277191164 0.6981727082110797 0.8166282109489627 0.663873623572418 0.6645842081309621 0.5047160976425189 0.8388512896173768 0.7663571264311222 0.8764424729367751 1.025968290046478 1.0 13.490084244753698 -7.806935170005341 1.2704365038147025 1.020200770254052 0.6874694541310635 0.6879137028856652 0.08512113201348903 0.2790866690897766 0.8176833059280826 0.07587093510330392 0.02867754468945841 1.559785324866792e-08 7.806935170005341 -0.33273131612298856 SASQS(ph)S(ph)LDKLDQELK ddPTM_A459_Selumetinib_30min_R2 1 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 2 SASQS(1)S(1)LDKLDQELK 89.23100000000002 0.033164 8430200.0 147150.0 139110.0 121750.0 116740.0 111690.0 105870.0 150220.0 123860.0 91199.0 130760.0 True False 138971.992088122 149779.28969084952 113916.73755137737 100839.81061226745 97658.50367873131 120452.63150782713 157205.52765528305 124220.41209387321 109441.34831296685 126984.61904471883 1.094400196918193 1.179507335751453 0.8970908320106117 0.7941104314118214 0.7690577363888453 0.9485607974727128 1.2379887331072879 0.9782319546127695 0.8618472783260943 1.0 16.95429423622376 -5.262186726749768 24.999611756739064 0.935307602386489 1.1369537770705402 0.2933227570772592 0.1248492459700719 88.15615498115746 2949040.5837920182 0.036449318834730036 0.08381283962804145 5.467808216202012e-06 5.262186726749768 0.20164617468405122 SASQS(ph)SLDKLDQELK ddPTM_A459_Selumetinib_30min_R1 4 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 S(0.001)AS(0.141)QS(0.827)S(0.03)LDKLDQELK;SASQS(0.5)S(0.5)LDKLDQELK;S(0.003)AS(0.164)QS(0.68)S(0.152)LDKLDQELK;S(0.002)AS(0.017)QS(0.49)S(0.49)LDKLDQELK 263.04 5.8611999999999997e-36 348134000.0 8507.89 9182.22 8286.57 8563.34 6223.530000000001 8068.349999999999 7507.02 7654.58 4555.83 6726.05 True False 8706.107283527868 8107.161413701728 7161.29930887081 7067.913422800282 5660.612810353461 7987.189724475664 6940.759437463522 7451.555672819995 7730.910765341962 7589.404034775087 1.1471397811522464 1.0682210851542817 0.9435917861346323 0.9312870141600968 0.7458573538075199 1.052413297259956 0.9145328678853519 0.9818367343043719 1.0186453020445985 1.0 12.88977088574001 -5.08473223569331 2.5807569129523884 0.9417690843012377 1.1452575506223306 0.4071556411735816 0.07914733442334435 0.3051571863267151 3.6592672222408007 0.02144248846688398 0.09937884943812984 8.227497600492873e-06 5.08473223569331 0.20348846632109285 SASQSS(ph)LDKLDQELK ddPTM_A459_Selumetinib_30min_R1 3 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 S(0.001)AS(0.009)QS(0.192)S(0.799)LDKLDQELK;SASQS(0.285)S(0.714)LDKLDQELK;SASQS(0.025)S(0.975)LDKLDQELK 265.43 1.8785e-36 99025000.0 8076.8 9498.300000000001 7935.1 7804.699999999999 5774.3 7509.0 6349.6 5292.1 4036.39 6823.2 True False 8264.97372528299 8386.234620360125 6857.557004384295 6441.755657363753 5252.015584535468 7433.466277626496 5870.644559907712 5151.7363168365455 6849.4590237385155 7699.024183596225 1.0735092562629682 1.0892594204637116 0.890704697225814 0.8366976780107735 0.6821663965838128 0.9655075890610222 0.7625180048681865 0.6691414644225941 0.8896528781312547 1.0 12.91045988700219 -5.3884086399685005 2.587346361657026 0.8128388238459918 1.089136398799023 0.47676547233713196 0.10282795977192569 0.22333354057955088 2.852698625163762 0.027725820267508187 0.0738536278976747 4.088757559050956e-06 5.3884086399685005 0.2762975749530312 SASQSS(ph)LDKLDQELK ddPTM_A459_Selumetinib_30min_R2 3 SASQSSLDKLDQELK 15 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 SASQS(0.066)S(0.934)LDKLDQELK;SASQS(0.077)S(0.923)LDKLDQELK;SAS(0.001)QS(0.256)S(0.744)LDKLDQELK 313.92 3.5692999999999977e-94 264430000.0 406847.0 318079.0 319367.0 322687.0 294151.0 239409.0 340196.0 283177.0 194327.0 225297.0 True False 384236.07247758255 342474.63651481393 298819.27492049773 278736.4739338759 257197.121636695 272385.4166114804 356015.7880855853 284000.9981875238 233197.82995004256 218792.09021809464 1.7561698509967674 1.5652971557309545 1.3657681802967878 1.273978751498868 1.175532083359676 1.244950931909665 1.6271876544106525 1.298040518304058 1.065842141357067 1.0 17.739201057131268 -5.069867444153549 1.532938449281801 1.2657828061754923 1.813787830249161 0.533691920171042 0.15868241596167448 0.5647830553350726 1.8370944340933737 0.04786757402832021 0.39812179855549734 8.513978631543037e-06 5.069867444153549 0.5480050240736687 SASQSS(ph)LDKLDQELKEQQK ddPTM_A459_Selumetinib_30min_R1 2 SASQSSLDKLDQELKEQQK 19 2 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 SASQS(0.232)S(0.768)LDKLDQELKEQQK;SASQS(0.231)S(0.769)LDKLDQELKEQQK 178.99 7.0322e-13 182399000.0 1426.8899999999999 984.6700000000001 2496.63 2711.1000000000004 1438.0 1546.35 1317.43 1023.6899999999999 590.46 943.14 True False 1460.1337607553803 869.3843786393363 2157.6013590069388 2237.6572786499014 1307.9331538995198 1530.7951229734629 1218.055194431022 996.5384157862482 1001.9674945078758 1064.201205961564 1.3720467074983904 0.816936096077621 2.027437430929641 2.102663731364649 1.2290280696663283 1.4384452060363018 1.1445722741222066 0.9364191754376195 0.9415207283124091 1.0 10.055555228170414 -7.302995837933 1.5896944307603276 0.9443491292747799 1.5330690789367059 0.3392369675667666 0.34592776924958707 0.5076073518368942 2.49604709080882 0.22004685755031594 0.12817212715819684 4.977418550718322e-08 7.302995837933 0.588719949661926 SASRS(ph)GGPSSPK ddPTM_A459_Selumetinib_30min_R1 2 SASRSGGPSSPK 12 1 Q93075 Q93075 TATDN2 Putative deoxyribonuclease TATDN2 1 SASRS(1)GGPSSPK;S(0.002)AS(0.002)RS(0.997)GGPSSPK 82.505 0.019912 5666400.0 1068.46 1052.17 1278.8600000000001 1383.62 1028.83 987.9 1151.73 935.64 590.54 1035.71 True False 1093.3530391387508 928.9814472594375 1105.1978362751447 1141.9967407641084 935.7725081546893 977.9626229414329 1064.854078836857 910.8237878129568 1002.1032486649067 1168.653467169722 0.9355665044032805 0.794916092200771 0.9457019273230276 0.9771902217770579 0.8007271055473524 0.8368285812815756 0.9111803530739961 0.7793788436009312 0.8574853682604722 1.0 10.19063148543799 -6.272643194401701 24.990007615147835 0.854209430720973 0.9071958787237917 0.08646053989175095 0.07284706490781861 1713.0689728082127 3820978.1213870435 0.022133126604711676 0.025319824774398803 5.337732502847119e-07 6.272643194401701 0.05298644800281871 SASS(ph)DTSEELNSQDSPPK ddPTM_A459_Selumetinib_30min_R2 2 SASSDTSEELNSQDSPPK 18 0 J3QRP6;O14745;O14745-2 J3QRP6 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 1 S(0.015)AS(0.266)S(0.714)DT(0.006)SEELNSQDSPPK;SAS(0.217)S(0.743)DT(0.04)SEELNSQDSPPK 313.59 9.439799999999999e-112 86575000.0 102328.0 79430.0 91843.0 105595.0 100703.0 89931.0 119623.0 134596.0 101818.0 79588.0 True False 96641.01941143983 85522.02559229515 85933.92137109762 91212.77883846482 88051.7888437575 102318.17893766328 125185.70652847765 134987.65207643266 122184.44503261724 77290.08764554198 1.2503675743601514 1.1065070334051819 1.1118362520844445 1.1801355337669344 1.139237792659383 1.3238201955068543 1.6196864351168612 1.7465066503158329 1.5808553044080385 1.0 16.2379957817773 -7.023435478131366 3.39690667583554 1.5467612726962354 1.155029327177516 0.38389065582460746 0.19004096557411634 0.20748865493834204 4.972881435906354 0.0715860901103212 0.05739162138839503 9.474679366053728e-08 7.023435478131366 -0.39173194551871937 SASS(ph)GAEGDVSSER ddPTM_A459_Selumetinib_30min_R2 1 SASSGAEGDVSSER 14 0 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 S(0.006)AS(0.225)S(0.769)GAEGDVSSER 91.845 0.016461 26037000.0 26417.0 15532.0 25817.0 24209.0 32601.0 26059.0 27214.0 34288.0 27423.0 18504.0 True False 24948.848895629777 16723.254456748466 24155.96232742426 20911.69243714563 28505.37092336213 29648.39070995061 28479.504923517972 34387.77240331604 32908.36626263982 17969.741440834205 1.3883810725810635 0.9306341169020251 1.344257645941002 1.1637169352713208 1.5862983347432533 1.6499063610663867 1.5848589150426795 1.9136487031011875 1.8313210777679463 1.0 14.133282030205324 -6.317198313496522 4.210286587400533 1.648850684490204 1.1949223935137583 0.3426504082258274 0.2570457889167004 0.21815745541032672 8.078385781037234 0.07782899571423978 0.09088895783942585 4.817277742575554e-07 6.317198313496522 -0.4539282909764457 SASS(ph)GAEGDVSSEREP ddPTM_A459_Selumetinib_30min_R1 1 SASSGAEGDVSSEREP 16 1 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 S(0.005)AS(0.069)S(0.925)GAEGDVSSEREP 258.42 2.6964e-38 319340000.0 2037.3 1943.0 2471.1 2480.2 2244.6 2036.9 2545.1 2204.6 1147.7 1604.7 True False 2084.7651261042797 1715.5126567238065 2135.5381927806857 2047.0796291200925 2041.5763263163155 2016.410635357226 2353.1210579282356 2146.1268464499644 1947.5630753085532 1810.678876101662 1.1513720923241328 0.947441691271759 1.1794129930860167 1.1305591820496599 1.127519823234349 1.113621339471579 1.2995794499985749 1.1852608846194264 1.075598274776143 1.0 10.822314991670813 -5.293009127790973 24.992836060173527 1.1496855944476911 1.0494067906520193 0.13625120637997878 0.0868698929644889 962.8842116798711 762285.3393189369 0.022110228465222554 0.046031690904193304 5.093201663002499e-06 5.293009127790973 -0.10027880379567189 SASS(ph)GAEGDVSSEREP ddPTM_A459_Selumetinib_30min_R2 1 SASSGAEGDVSSEREP 16 1 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 S(0.012)AS(0.051)S(0.937)GAEGDVSSEREP 99.747 0.045674 0.0 7363.1 7579.2 10516.0 9657.3 10380.0 9380.5 8583.6 6583.1 6154.3 8461.5 True False 6953.888378824679 8160.500269030899 9839.412008955089 8341.959080228287 9075.971601622621 10672.578727299264 8982.754408080731 6602.25573110913 7385.3319655094065 8217.19450938276 0.8462606514771458 0.9931005356770946 1.1974174394582004 1.0151833537228632 1.1045097680551763 1.2988105265261565 1.0931656051008432 0.8034683520720337 0.8987656257955807 1.0 13.004430201895152 -7.746813563095434 24.82618104839661 0.888337753663966 1.0867063964170696 0.30457573441542696 0.12209650902053291 243.2399889396301 412882.45064273814 0.060739949085980065 0.03486824328516047 1.791374702575585e-08 7.746813563095434 0.19836864275310362 SASS(ph)SWLEGTSTQAK ddPTM_A459_Selumetinib_30min_R1 2 SASSSWLEGTSTQAK 15 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 SAS(0.028)S(0.486)S(0.486)WLEGTSTQAK;SAS(0.057)S(0.886)S(0.057)WLEGTSTQAK 317.91 2.0056999999999986e-197 34879000.0 5027.0 5315.2 5831.9 6221.9 5255.6 4795.3 5383.5 4692.3 2486.0 4228.6 True False 5144.119319160756 4692.893913030556 5039.96001233365 5135.361964527986 4780.231907951543 4747.063635784035 4977.418260719285 4567.844961261527 4218.5604297438895 4771.382000052029 1.078119362294753 0.9835502403662886 1.0562893543796519 1.0762839706550404 1.0018547892202756 0.9949032870837571 1.043181673709003 0.9573421204195592 0.8841380609848234 1.0 12.220191478743473 -7.8496176348755995 4.752874927036955 0.9360028502358676 1.0313378399412676 0.4879935550547285 0.040430728708535625 0.16760477279999592 6.533801303345003 0.022496195268961173 0.010480793872499465 1.4137817301884614e-08 7.8496176348755995 0.0953349897054 SASSASSLFS(ph)PSSTLFSSSR ddPTM_A459_Selumetinib_30min_R1 1 SASSASSLFSPSSTLFSSSR 20 0 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2;E9PR38;Q14671-4;H0YDK8 Q5T1Z4 PUM1 Pumilio homolog 1 1 SASSAS(0.004)S(0.004)LFS(0.985)PS(0.006)S(0.002)TLFSSSR 190.37 1.4634e-15 28351000.0 1452.3 1531.9 1710.3 1507.8 1408.0 1209.3 1418.2 1369.9 650.24 1096.5 True False 1486.1357643161255 1352.544435839011 1478.0506540054268 1244.491034911409 1280.6466486025893 1197.1355399565487 1311.224032200629 1333.565801937678 1103.4097883494246 1237.246455814465 1.2011638888371836 1.0931891778575729 1.1946291274946053 1.0058554050107786 1.0350780497969214 0.9675804964569393 1.0597921101640702 1.0778497652351788 0.8918269946653941 1.0 10.272917194164462 -5.7696885222461205 24.98842217770741 1.0105936827407764 1.156013579324197 0.6247939464148581 0.055776620903549866 116.1663622726967 351893.40921938966 0.015127667396608225 0.022865830024964014 1.6994620765352082e-06 5.7696885222461205 0.14541989658342058 SASSASSLFS(ph)PSSTLFSSSR ddPTM_A459_Selumetinib_30min_R2 2 SASSASSLFSPSSTLFSSSR 20 0 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2;E9PR38;Q14671-4;H0YDK8 Q5T1Z4 PUM1 Pumilio homolog 1 1 SASSASSLFS(0.999)PSSTLFSSSR;SASSASSLFS(0.772)PS(0.225)S(0.001)T(0.001)LFSSSR 295.16 2.7371999999999992e-86 23775000.0 33108.0 31192.0 34798.0 41838.0 41383.0 30969.0 34097.0 32283.0 32336.0 33240.0 True False 31267.989901824996 33584.32610191206 32559.134565197717 36139.592225424385 36184.09757128602 35234.698641408366 35682.57806192374 32376.938185261646 38804.10354332939 32280.27483210812 0.9686407586196807 1.0403977746963555 1.0086387038072 1.1195565221606332 1.1209352386087772 1.0915241219186145 1.1053988309427731 1.0029945021737354 1.2020995405135841 1.0 14.97836524122684 -5.75060557621118 24.677604713059985 1.0936824558938145 1.0093429069728768 0.31909854378734415 0.05738523676501064 212.62802640351993 484325.83665652113 0.014637292766166715 0.025027882333674093 1.775801521640851e-06 5.75060557621118 -0.08433954892093776 SASSEEASES(ph)PTAR ddPTM_A459_Selumetinib_30min_R1 1 SASSEEASESPTAR 14 0 A0A075B6Q3;Q5H9F3-3 A0A075B6Q3 BCORL1 1 SASSEEAS(0.001)ES(0.998)PT(0.001)AR 260.73 7.937899999999999e-36 6050400.0 873.54 1080.6 1006.1 1348.9 1182.6 780.87 992.19 966.94 471.64 889.89 True False 893.891782387048 954.0828496426888 869.477146111711 1113.3399369889908 1075.6340388049884 773.0151567732322 917.3483094832478 941.293610136228 800.3386327773167 1004.1160497626398 0.8902275614440707 0.9501718948404636 0.8659130050926328 1.1087761591423322 1.0712248241219275 0.7698464305554752 0.9135879360758123 0.9374350806948438 0.7970579027857452 1.0 9.971710301701494 -6.755042258208732 24.99999870606779 0.8815503171664192 0.9768778339105325 0.20570346273842932 0.09199445999718882 262.81281093669463 1027073.2590894712 0.03163512504347656 0.030904987338081252 1.7577525708253757e-07 6.755042258208732 0.09532751674411333 SASSEEASES(ph)PTAR ddPTM_A459_Selumetinib_30min_R2 2 SASSEEASESPTAR 14 0 A0A075B6Q3;Q5H9F3-3 A0A075B6Q3 BCORL1 1 SASSEEAS(0.031)ES(0.954)PT(0.015)AR;SASSEEAS(0.058)ES(0.935)PT(0.006)AR 186.29 8.2896e-05 13679600.0 22211.7 18333.2 23936.0 26612.0 24493.2 18379.8 19114.3 19422.1 17760.2 25712.0 True False 20977.262634480077 19739.297489470835 22395.98381954632 22987.399691739407 21416.14524401379 20911.450614787598 20003.15282426692 19478.61509549826 21312.73626144973 24969.627752201093 0.8401111479377547 0.7905323093064853 0.8969290228033975 0.9206144328568554 0.8576878060236978 0.8374754650855473 0.8010993605022255 0.7800923301221903 0.8535464153874298 1.0 14.607886693244227 -6.721288411284308 5.602714776876928 0.8373192643391593 0.8627952024635557 0.0 0.06447570970478397 0.8395815954079907 64.40473637666551 0.02169977518685004 0.02121000188197437 1.8998162090629967e-07 6.721288411284308 0.025475938124396413 SASSGAEGDVSS(ph)EREP ddPTM_A459_Selumetinib_30min_R1 2 SASSGAEGDVSSEREP 16 1 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 SASSGAEGDVS(0.022)S(0.978)EREP;SASSGAEGDVS(0.025)S(0.975)EREP 274.38 3.0222e-50 162652000.0 8651.3 10053.9 10697.099999999999 9679.2 9072.6 8351.0 9545.0 8204.4 4888.3 6373.799999999999 True False 8852.858457500588 8876.784714068692 9244.492574964303 7988.9094210866915 8251.984931897628 8266.996522101323 8825.012965276408 7986.792660352935 8295.088072693912 7191.939316069533 1.2309417624979022 1.2342685781892755 1.2853963539859943 1.1108143534020682 1.1473935706687 1.149480850544679 1.2270699984297653 1.1105200293483284 1.1533868276890942 1.0 12.812165132436736 -14.522878745280225 0.06930546308893587 0.3654410487531966 1.411906280608608 0.6356084627620706 0.047265799954087605 213.93952494757878 1.0646494982663464 21.735731163654872 2.748492908815444 3.000000000000774e-15 14.522878745280225 1.0464652318554113 SASSGAEGDVSS(ph)EREP ddPTM_A459_Selumetinib_30min_R2 1 SASSGAEGDVSSEREP 16 1 Q8TEA8 Q8TEA8 DTD1 D-tyrosyl-tRNA(Tyr) deacylase 1 1 SASSGAEGDVS(0.027)S(0.973)EREP 184.01 3.9975e-06 54566000.0 122470.0 116110.0 137040.0 123520.0 146440.0 95501.0 101110.0 93290.0 88455.0 127730.0 True False 115663.60768625415 125015.26364750582 128222.99559787058 106696.36291611505 128042.8980097896 108655.39587823758 105811.81534566416 93561.45845500912 106148.47163920096 124042.10301760443 0.9324544237196528 1.0078454057632615 1.0337054312895098 0.8601624796781491 1.0322535243667819 0.8759557701373129 0.85303145280153 0.7542717849739342 0.8557455013813822 1.0 16.920470365249656 -6.911397523906555 6.037923526253077 0.8478551361195624 0.9719205849170064 0.3260607101954208 0.0740659276032149 0.21508585007378592 11.807535672807795 0.025551401142661332 0.022492025265100312 1.2263162300276055e-07 6.911397523906555 0.12406544879744397 SASSSAAGS(ph)PGGLTSLQQQK ddPTM_A459_Selumetinib_30min_R1 2 SASSSAAGSPGGLTSLQQQK 20 0 E5RJ10;E5RHB8;E5RJX6;E5RG91;Q8NEZ2-3;Q8NEZ2-2;Q8NEZ2 E5RJ10 VPS37A Vacuolar protein sorting-associated protein 37A 1 SASSS(0.003)AAGS(0.997)PGGLTSLQQQK;SASS(0.001)S(0.001)AAGS(0.996)PGGLT(0.002)SLQQQK 245.22 7.5816e-31 3322700.0 936.36 1096.29 1360.69 1288.8899999999999 1139.26 1017.8900000000001 994.95 864.0799999999999 622.65 716.6800000000001 True False 958.1753661606061 967.9358571486056 1175.9157717351595 1063.8095569617758 1036.2141341526894 1007.6509507701741 919.90012046116 841.1617914725957 1056.5915734432963 808.6728590543651 1.1848739022613721 1.196943666788171 1.4541303798797403 1.315500508086495 1.2813761739999578 1.2460551130014272 1.1375429633397867 1.0401756186750502 1.3065747930242633 1.0 9.659412381834827 -7.162875137998022 2.768561394319362 1.1221699986770295 1.2914822822663423 0.37488417890610537 0.1015735114080593 0.3167039725394644 4.714879528312721 0.044496607407236315 0.032290041496128845 6.872660042892485e-08 7.162875137998022 0.16931228358931283 SASSSAAGS(ph)PGGLTSLQQQK ddPTM_A459_Selumetinib_30min_R2 3 SASSSAAGSPGGLTSLQQQK 20 0 E5RJ10;E5RHB8;E5RJX6;E5RG91;Q8NEZ2-3;Q8NEZ2-2;Q8NEZ2 E5RJ10 VPS37A Vacuolar protein sorting-associated protein 37A 1 SASSSAAGS(1)PGGLTSLQQQK;SASSS(0.005)AAGS(0.995)PGGLTSLQQQK;SASSS(0.001)AAGS(0.999)PGGLTSLQQQK 219.96 2.1453e-42 13267300.0 45936.4 54787.4 57205.3 64043.2 61804.6 49022.9 54860.6 51855.4 36917.2 58273.3 True False 43383.438785979015 58989.41741074304 53524.773278421286 55320.4056793178 54040.15360786561 55775.35948942157 57411.72660421662 52006.290628876406 44301.67155275232 56590.79841678361 0.7666164818256465 1.0423853181270553 0.9458211365780447 0.9775512490898337 0.9549282766761331 0.9855906092478773 1.0145063899149644 0.9189884589691963 0.7828423134530895 1.0 15.788279871517021 -10.770566752955938 4.1869091993544 1.000030097937931 0.9413959454027798 0.04293369459895047 0.08671578967052772 3.2708717457722646e-05 5.8772081635933545e-06 0.08176601913625652 0.019817141572159615 1.6960288951866817e-11 10.770566752955938 -0.05863415253515125 SAST(ph)DLGTADVVLGR ddPTM_A459_Selumetinib_30min_R2 1 SASTDLGTADVVLGR 15 0 A0A0U1RRA6;B5MCU0;B5MCG9;Q9Y2K5;H7C0E9;Q9Y2K5-2;Q9Y2K5-3 A0A0U1RRA6;Q9Y2K5-3 R3HDM2 R3H domain-containing protein 2 1 SAS(0.275)T(0.721)DLGT(0.003)ADVVLGR 188.19 5.7669e-05 3586500.0 15711.0 11671.0 18571.0 18480.0 17800.0 11842.0 12893.0 16353.0 12248.0 13649.0 True False 14837.845516116116 12566.128171820203 17376.162078575973 15962.992120221868 15563.804865980981 13473.128009027023 13492.550046994826 16400.584522615114 14697.942237713334 13254.917905639108 1.1194219097957276 0.9480351565568075 1.3109218934644282 1.204307128407838 1.1741909664608026 1.0164625767538764 1.017927847086448 1.237320716685671 1.1088670893586081 1.0 13.694240114447634 -6.727486642167735 24.98944234865494 1.0873113116380628 1.1518830887195912 0.10816695796766573 0.10562733578654028 550.3397361628893 405052.3614305529 0.03690201878220308 0.03690035035497013 1.872894687775133e-07 6.727486642167735 0.06457177708152839 SAST(ph)LCLPSVGAARPQVK ddPTM_A459_Selumetinib_30min_R2 1 SASTLCLPSVGAARPQVK 18 1 Q8IUC4-2;Q8IUC4;A8MT19 Q8IUC4-2 RHPN2;RHPN2P1 Rhophilin-2;Putative rhophilin-2-like protein RHPN2P1 1 S(0.029)AS(0.483)T(0.488)LCLPSVGAARPQVK 80.411 0.015624 173470000.0 36803.0 30815.0 45125.0 48602.0 53515.0 49706.0 34102.0 43734.0 32207.0 32891.0 True False 34757.63659408196 33178.41141415813 42221.706628385145 41982.32375687356 46791.96726982989 56552.550313857166 35687.81057183106 43861.25869944656 38649.2999387682 31941.351368919033 1.0881705095265115 1.0387291079501049 1.3218509805903063 1.3143565302539149 1.4649338636110885 1.7705121383463567 1.117291818985391 1.3731810590245206 1.2100082896422606 1.0 14.963137730870773 -5.299846048238873 5.14820828364554 1.3500815131563513 1.0619746680472857 0.20463848764121328 0.19745151021860233 0.25175095720184976 17.405870491208212 0.05208170335223827 0.11738665881898991 5.013649294948801e-06 5.299846048238873 -0.2881068451090656 SASVVSSDSISTSADNFS(ph)PDLR ddPTM_A459_Selumetinib_30min_R1 2 SASVVSSDSISTSADNFSPDLR 22 0 Q13614 Q13614 MTMR2 Myotubularin-related protein 2 1 SASVVSSDSISTS(0.004)ADNFS(0.996)PDLR;SASVVSSDSISTSADNFS(1)PDLR 338.24 1.6638999999999983e-285 0.0 3432.2 4293.5 4493.299999999999 4467.3 4211.7 3468.6 4065.9 3316.7 1737.8899999999999 2853.7 True False 3512.1635821013638 3790.8150240060027 3883.1345399301754 3687.169916606804 3830.7524786360304 3433.7090332368193 3759.2058895251284 3228.7303418400606 2949.0723995364488 3220.0001923919212 1.0907339665381866 1.177271676244858 1.2059423316511222 1.1450837566155092 1.1896746117243 1.0663692012658386 1.1674551754398088 1.002711226374696 0.9158609389230444 1.0 11.652845059201626 -7.852190080551128 4.113813557438434 0.9582027531394506 1.1507112426453876 0.765402120349531 0.04498408260619551 0.0997006996568558 3.0940442992643327 0.026251234865358044 0.01198313723919441 1.4054322646211385e-08 7.852190080551128 0.19250848950593702 SASVVSSDSISTSADNFS(ph)PDLR ddPTM_A459_Selumetinib_30min_R2 2 SASVVSSDSISTSADNFSPDLR 22 0 Q13614 Q13614 MTMR2 Myotubularin-related protein 2 1 SASVVSSDSISTSADNFS(1)PDLR;SASVVSS(0.001)DSIS(0.004)T(0.004)S(0.062)ADNFS(0.93)PDLR 288.96 4.725099999999998e-92 17834600.0 55550.0 51193.0 71605.0 69101.0 70018.0 49463.0 48697.0 50313.0 45143.0 52532.0 True False 52462.75338426902 55119.338488560716 66998.01225762915 59689.324594126105 61221.71287113799 56276.07926959157 50961.5069912749 50459.40250023447 54172.86140080769 51015.264665472445 1.0283736393075353 1.0804479570967696 1.3132934367186369 1.1700287156311537 1.200066554051877 1.1031223622697324 0.9989462433538265 0.9891040031080308 1.0618951358194626 1.0 15.638641370988989 -7.075249944844167 3.5904473171037043 1.0122559143933232 1.163061027662532 0.47222449611673534 0.07250130099378364 0.22966880298521236 5.6845212599972985 0.030937763912782294 0.024055978137600506 8.409110418433463e-08 7.075249944844167 0.15080511326920876 SAT(ph)FPNAGPR ddPTM_A459_Selumetinib_30min_R2 3 SATFPNAGPR 10 0 Q86X27;Q86X27-3 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 S(0.001)AT(0.999)FPNAGPR;S(0.004)AT(0.996)FPNAGPR;S(0.034)AT(0.966)FPNAGPR 125.23 0.0085635 80876000.0 131965.0 106361.0 143131.0 149867.0 143900.0 103193.0 84624.0 112305.0 73823.0 132528.0 True False 124630.91359775097 114518.5466954816 133922.10728925007 129454.85606500503 125821.99551767782 117406.89905721368 88559.18367927494 112631.78895690653 88589.66278696206 128701.57229090304 0.9683713367234458 0.88979912721374 1.040563101952998 1.0058529492739945 0.9776259394351722 0.9122413733364492 0.6880971390085693 0.8751391840212012 0.6883339590189591 1.0 16.973670152878356 -7.033981435226492 6.35087991852707 0.8014451349698735 0.9741856170012718 0.4147999737733743 0.09116755077533832 0.17682958295155926 22.216171039652636 0.03247172823481555 0.025796527339624804 9.247377028288661e-08 7.033981435226492 0.17274048203139836 SAT(ph)PEPVTDNR ddPTM_A459_Selumetinib_30min_R1 2 SATPEPVTDNR 11 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.001)AT(0.999)PEPVTDNR;S(0.099)AT(0.9)PEPVT(0.001)DNR 114.71 0.014939 15341200.0 9220.3 12958.2 6400.7 7482.1 9171.1 8663.5 11698.0 11878.099999999999 6679.8 12329.0 True False 9435.115050419323 11441.047919896251 5531.520096528405 6175.491691411762 8341.575624289218 8576.353055828622 10815.610441886174 11563.054202493557 11335.132726710874 13911.547244629777 0.6782218314401747 0.8224137630925845 0.3976207677879768 0.44391120432672676 0.599615231692455 0.6164916745072565 0.7774556094801952 0.8311839078113471 0.8148002898158242 1.0 13.763995265138938 -7.624986116918238 1.115451950447824 0.9235238480443737 0.5804346690854376 0.5675587202909731 0.11687564246915808 0.42709746104652013 0.9742112823117721 0.10546615350124543 0.045363089986024646 2.3714495125222772e-08 7.624986116918238 -0.3430891789589361 SAT(ph)PEPVTDNR ddPTM_A459_Selumetinib_30min_R2 2 SATPEPVTDNR 11 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.082)AT(0.917)PEPVTDNR;S(0.146)AT(0.853)PEPVT(0.001)DNR 145.23 0.00165 24861000.0 114492.0 66769.0 102889.0 100588.0 96808.0 107965.0 121378.0 115227.0 103063.0 83473.0 True False 108128.99298778975 71889.96760382695 96269.23375707306 86887.74087602163 84646.11356549927 122836.19874131064 127022.31750594414 115562.29149314328 123678.47982082359 81062.91760109985 1.333889726494654 0.886841600713019 1.187586588368328 1.071855583876033 1.0442026523401473 1.5153192406147002 1.5669596069932317 1.4255876165450938 1.5257097015608223 1.0 16.30675448107396 -6.7593711292428225 24.98695393451426 1.4433297559492126 1.0955228675947268 0.3962614567283299 0.18334276482599488 46.84503230621161 565946.3997334125 0.05786945766204955 0.05515646525929337 1.740319036534863e-07 6.7593711292428225 -0.3478068883544858 SAT(ph)PTPTVIAR ddPTM_A459_Selumetinib_30min_R1 2 SATPTPTVIAR 11 0 Q92618;A0A087WUJ4 Q92618 ZNF516 Zinc finger protein 516 1 S(0.046)AT(0.893)PT(0.061)PTVIAR;S(0.032)AT(0.939)PT(0.03)PTVIAR 119.03 0.012017 12652500.0 4473.6 5064.9 5131.5 5731.6 5527.4 4038.9 4916.3 4808.0 3098.3 4432.8 True False 4577.826175889709 4471.8991533918725 4434.670485311843 4730.683655457112 5027.447645941732 3998.27233302779 4545.459532864164 4680.476221414964 5257.58880912128 5001.793059128464 0.9152370203591291 0.8940592104726295 0.8866161460275529 0.9457975569028056 1.0051290780146227 0.7993678038580164 0.9087660123340222 0.9357596697993964 1.0511408102992144 1.0 12.2882296543071 -8.125332162614946 4.155453033502577 1.024344038313664 0.9082751291626174 0.4631113844322501 0.04982239199759317 0.2116729655586414 5.905107637568116 0.038078387482066135 0.0132301995303447 7.493208850069381e-09 8.125332162614946 -0.1160689091510465 SAT(ph)PVNCEQPDILVSSTPINEGQTVLDK ddPTM_A459_Selumetinib_30min_R1 2 SATPVNCEQPDILVSSTPINEGQTVLDK 28 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.204)AT(0.796)PVNCEQPDILVSSTPINEGQTVLDK;S(0.217)AT(0.783)PVNCEQPDILVSSTPINEGQTVLDK 167.79 1.2254e-21 28900000.0 3779.2 5030.6 3839.8 4188.2 3865.3 4258.3 4234.3 3747.6000000000004 2294.6000000000004 3464.5 True False 3867.2480069569006 4441.615013337507 3318.3762505116288 3456.809492250937 3515.6842974741407 4215.465368227048 3914.9033419455104 3648.2014740795985 3893.7686090467955 3909.2023220877454 0.9892678066587153 1.136194713750559 0.8488627543686251 0.8842748999506366 0.8993354673944216 1.078344127754365 1.0014583588640458 0.9332342440979732 0.9960519533732632 1.0 11.932658538391136 -6.73672034205571 24.99668240221372 0.9976225291634297 0.9523966659699481 0.08853159512813846 0.08000076500810124 759.9866692477109 768521.0189012022 0.028762961197882502 0.028750982420310826 1.8334946959522537e-07 6.73672034205571 -0.04522586319348165 SAT(ph)TTGSPGTEK ddPTM_A459_Selumetinib_30min_R1 1 SATTTGSPGTEK 12 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 S(0.016)AT(0.315)T(0.315)T(0.315)GS(0.04)PGTEK 153.49 0.0010933 46782000.0 4269.3 5970.2 6234.8 5849.3 6046.0 5750.4 5262.9 5697.9 3775.9 4635.8 True False 4368.766383388305 5271.206208529321 5388.148405304939 4827.829559959747 5499.140367507998 5692.556196945455 4865.915215814901 5546.773182612379 6407.4265191753675 5230.850086515914 0.8351924278331188 1.0077150217165345 1.030071272582349 0.9229531491267406 1.0512899961869837 1.088265980250462 0.9302341178460185 1.0603961289028052 1.2249302528650998 1.0 12.352829708369594 -2.8819235298600114 0.4244631641370644 1.0641809963868643 1.1853163726300108e-14 0.35533103326164384 0.08081552952904494 31.590663836353198 1.2126111191297606 0.05677220893146202 23.865504255566947 0.001312430970213788 2.8819235298600114 -1.0641809963868525 SAT(ph)TTGSPGTEK ddPTM_A459_Selumetinib_30min_R2 1 SATTTGSPGTEK 12 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 SAT(0.934)T(0.051)T(0.008)GS(0.007)PGTEK 233.32 6.428899999999999e-10 34995000.0 71337.0 44113.0 56371.0 67250.0 65296.0 50699.0 74680.0 106340.0 56657.0 100900.0 True False 67372.37512463717 47496.325254348776 52744.15123210414 58090.4339872793 57092.932726353625 57682.3270503007 78152.76797561262 106649.4317944652 67989.9831288476 97986.75483031613 0.6875661434170981 0.4847218926333285 0.5382783757196704 0.5928396556031947 0.5826596954376291 0.5886747361945939 0.7975850216792048 1.088406611476727 0.6938691177862354 1.0 16.580299128450214 -7.377718881402454 3.3262865831778834 0.9221999020775605 0.57242021960727 0.6924274859831105 0.10528791540220964 0.13427699174458974 2.7765994704884336 0.045399850067217466 0.028905845416847747 4.19064737735383e-08 7.377718881402454 -0.34977968247029056 SATDGNTS(ph)TTPPTSAK ddPTM_A459_Selumetinib_30min_R2 1 SATDGNTSTTPPTSAK 16 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 SATDGNT(0.085)S(0.398)T(0.356)T(0.161)PPTSAK 139.49 0.00040197 34162000.0 77643.0 76138.0 84228.0 93057.0 93993.0 69846.0 71416.0 80815.0 59515.0 79867.0 True False 73327.91288955526 81977.53977774373 78808.86218051244 80382.47606772129 82184.7590319186 79466.65250114017 74736.98550811941 81050.15827035661 71419.6629880395 77561.03219061295 0.9454220865620452 1.056942351879444 1.0160883623471235 1.0363770800545098 1.0596140447169713 1.0245693005457173 0.9635893617873315 1.0449855550035594 0.9208188825094475 1.0 16.243044382663697 -8.25274619690033 24.994532944988382 0.9604094388234512 1.0199981643840696 0.25437953744386665 0.03967553744762948 733.7966163157959 2109818.2345705843 0.026627659942758862 0.009719044726792163 5.587966619095903e-09 8.25274619690033 0.05958872556061845 SATDGNTST(ph)TPPTSAKK ddPTM_A459_Selumetinib_30min_R1 2 SATDGNTSTTPPTSAKK 17 1 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 SAT(0.001)DGNT(0.004)S(0.112)T(0.77)T(0.112)PPTSAKK;SATDGNT(0.004)S(0.134)T(0.514)T(0.335)PPT(0.01)S(0.004)AKK 93.5 0.0091135 8318000.0 2876.1 2804.6 5297.6 5977.700000000001 4518.4 3853.8999999999996 3183.6 3126.7 2190.4 2726.3 True False 2943.1075340836005 2476.2361281768344 4578.215017633832 4933.806910326254 4109.71151778831 3815.1332650612285 2943.458488868937 3043.7697590470398 3716.9488195136837 3076.247161410832 0.9567201137160347 0.8049535678534946 1.4882468076895894 1.6038395653694828 1.3359497147503288 1.2401907469982119 0.9568341990826915 0.9894425250444123 1.208273790916401 1.0 11.586955706107682 -7.240753817067763 19.323915549344235 1.0377580746504067 1.2510319179532599 0.15584391597067948 0.22650880831066952 93.11528517643848 86985.09244485122 0.09812939780470087 0.07576156806997272 5.744419964858148e-08 7.240753817067763 0.21327384330285315 SATDGNTSTT(ph)PPTS(ph)AK ddPTM_A459_Selumetinib_30min_R2 1 SATDGNTSTTPPTSAK 16 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 2 SATDGNT(0.101)S(0.225)T(0.195)T(0.479)PPT(0.187)S(0.813)AK 153.92 0.021969 3989800.0 33157.0 29279.0 32846.0 32279.0 33944.0 25670.0 29770.0 29327.0 23766.0 31873.0 True False 31314.266677987536 31524.605153176577 30732.724120020794 27882.54451561914 29679.651256789795 29205.80949094103 31154.363988135883 29412.336714653804 28519.864077522438 30952.743674000678 1.0116798371024707 1.0184753082052704 0.9928917592476724 0.900810112644056 0.9588698038978613 0.943561249320621 1.0065138107386764 0.9502335891263569 0.9214001956627262 1.0 14.917779676208271 -5.53469705478149 24.990761990301074 0.9537325550288038 1.0127290735214503 0.4114558401474374 0.029914734574922736 197.76481594020515 418188.3115902544 0.00809429641830239 0.01403234777314177 2.9194627960118698e-06 5.53469705478149 0.05899651849264642 SATDGNTSTT(ph)PPTSAK ddPTM_A459_Selumetinib_30min_R1 2 SATDGNTSTTPPTSAK 16 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 SATDGNT(0.002)S(0.005)T(0.014)T(0.977)PPT(0.002)SAK;SATDGNT(0.044)S(0.065)T(0.209)T(0.681)PPTS(0.001)AK 145.79 0.00085396 204260000.0 10537.0 12850.3 13989.1 14694.0 11529.1 11688.7 12157.2 10702.2 6476.799999999999 10095.599999999999 True False 10782.491598567123 11345.780902057599 12089.457056625917 12127.968740541353 10486.294940627928 11571.122290490452 11240.172616182132 10418.342890355078 10990.656553244256 11391.468599471507 0.9465409577714469 0.9959893057672978 1.0612729123606408 1.0646536602931087 0.9205393360004895 1.0157708981462916 0.986718483049991 0.9145741656908419 0.9648147170202579 1.0 13.475666132266555 -6.261583322014412 24.999980450290796 0.9662158185481753 1.0187594788128447 0.24555874822265245 0.042918838316184586 19.802511861076717 3439317.624477709 0.013735191028306245 0.016534741975537712 5.47541041834483e-07 6.261583322014412 0.05254366026466939 SATDGNTSTT(ph)PPTSAK ddPTM_A459_Selumetinib_30min_R2 3 SATDGNTSTTPPTSAK 16 0 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 SATDGNT(0.083)S(0.343)T(0.214)T(0.359)PPTSAK;SATDGNT(0.157)S(0.077)T(0.271)T(0.48)PPT(0.011)S(0.003)AK;SATDGNT(0.004)S(0.061)T(0.061)T(0.863)PPT(0.01)SAK 172.42 1.476e-05 42933300.0 102589.0 106192.0 123242.0 129005.0 126263.0 96791.0 95598.0 103810.0 87532.0 112102.0 True False 96887.5140763056 114336.5849389026 115312.74389574373 111434.29645396203 110400.71313445824 110123.08166878336 100043.49642384319 104112.06991332928 105040.84584842612 108865.32398402508 0.8899758943492686 1.0502571503455074 1.0592238159569043 1.0235977111528545 1.0141035647922059 1.0115533361655438 0.9189656794529321 0.9563382177469725 0.9648696389663971 1.0 16.73218497134949 -7.189081066942509 10.348041115390911 0.9564309392653987 1.0133922349286435 0.19375405501261422 0.0470870629620585 0.890295410743837 124.34361314685574 0.017924049640911075 0.013880353143290669 6.470218290949247e-08 7.189081066942509 0.056961295663244815 SATLS(ph)STESTASEMQEEMK ddPTM_A459_Selumetinib_30min_R1 1 SATLSSTESTASEMQEEMK 19 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SATLS(0.49)S(0.49)T(0.02)ESTASEMQEEMK 232.62 2.5148e-65 0.0 1862.1 2159.4 1955.2 2023.2 2103.2 1721.2 1837.3 1736.2 922.5 1764.3 True False 1905.4833069841343 1906.5764441221759 1689.6945791448334 1669.8861001676378 1912.9659313501177 1703.8862907245616 1698.7109817812843 1690.1503360275908 1565.4151232657837 1990.7650907373113 0.9571613023806884 0.9577104064126648 0.8487664300558074 0.8388162460439614 0.9609199700410763 0.8558952026296083 0.8532955443538243 0.8489953655966596 0.7863384437216585 1.0 10.959107278486595 -5.2529668722667715 23.80686155661402 0.8691787120348239 0.9574358834522202 0.23986655304371185 0.058794527570927076 422.8077368593995 1188031.0163424534 0.014542283614720236 0.037050034361504655 5.585127961467804e-06 5.2529668722667715 0.08825717141739631 SATLSGSAT(ph)NLASLTAALAK ddPTM_A459_Selumetinib_30min_R1 2 SATLSGSATNLASLTAALAK 20 0 Q9NQT8;H0YBA8;Q9NQT8-2 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 SATLSGS(0.02)AT(0.978)NLAS(0.001)LTAALAK;SAT(0.002)LS(0.022)GS(0.145)AT(0.708)NLAS(0.07)LT(0.053)AALAK 241.38 8.0552e-30 36581000.0 2369.17 3054.8 2449.4 2400.3 2798.56 2215.65 2382.34 2430.16 1516.0500000000002 2364.21 True False 2424.367051397671 2697.142595862008 2116.7849335911187 1981.132664211337 2545.430742125899 2193.362572649241 2202.638175767064 2365.704262527824 2572.62612208899 2667.6793828555546 0.9087925134401137 1.0110445105194446 0.7934930063916662 0.7426427167160846 0.954174162939027 0.822198719510816 0.8256757502130191 0.8868023187987124 0.9643685589139962 1.0 11.381369570165344 -8.306183416623252 2.794268243507294 0.9968458708248655 0.8647942731502092 0.2836241668847076 0.0740376397520257 0.36400702904437804 5.285823924909087 0.07274491643913761 0.020372890091335444 4.9410196765427e-09 8.306183416623252 -0.13205159767465635 SATLSS(ph)TESTASEMQEEMK ddPTM_A459_Selumetinib_30min_R2 2 SATLSSTESTASEMQEEMK 19 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SAT(0.003)LS(0.13)S(0.861)T(0.002)ES(0.003)T(0.001)ASEMQEEMK;SATLS(0.001)S(0.963)T(0.036)ESTASEMQEEMK 177.66 7.4781e-13 14607200.0 159247.0 142890.0 171378.0 177099.0 174701.0 117203.0 161233.0 160400.0 125432.0 164175.0 True False 150396.68925624996 153849.20353623413 160351.72606225836 152977.8106871848 152753.49853324395 133346.64938709637 168730.65397712847 160866.73744435053 150521.90486290483 159434.84117212272 0.94331131232404 0.9649660162432222 1.0057508439397245 0.9595005054261193 0.9580935848791939 0.8363708233831899 1.058304776651486 1.0089810750379333 0.9440966839889429 1.0 17.282607409245962 SATPEPVTDNRDVEDMELS(ph)DVEDDGSK ddPTM_A459_Selumetinib_30min_R1 2 SATPEPVTDNRDVEDMELSDVEDDGSK 27 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 SATPEPVTDNRDVEDMELS(0.999)DVEDDGS(0.001)K;SATPEPVTDNRDVEDMELS(0.993)DVEDDGS(0.007)K 144.08 3.1646999999999996e-13 13932300.0 1486.52 1844.07 1986.6399999999999 1932.4699999999998 1529.56 1968.94 1529.0 1488.73 916.21 1298.5 True False 1521.1530237355973 1628.1654271151144 1716.8651998323926 1595.000391454603 1391.2115680657516 1949.1342512544832 1413.666298995038 1449.244044323439 1554.7414526692075 1465.1751234610888 1.0382056038067828 1.111242882194863 1.1717815654532493 1.0886073384093748 0.9495189658826463 1.3303080430755396 0.9648445952696939 0.989126843008352 1.0611301186963522 1.0 10.516857396169277 SATPEPVTDNRDVEDMELS(ph)DVEDDGSK ddPTM_A459_Selumetinib_30min_R2 2 SATPEPVTDNRDVEDMELSDVEDDGSK 27 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 SATPEPVTDNRDVEDMELS(0.999)DVEDDGS(0.001)K;SATPEPVT(0.059)DNRDVEDMELS(0.939)DVEDDGS(0.002)K 82.50299999999999 4.6355e-05 8794300.0 40826.0 38760.0 43873.0 49284.0 47467.0 37340.0 36774.0 35853.0 31497.3 34933.0 True False 38557.05435942691 41732.767366956665 41050.25894531061 42571.43418035795 41503.771099635924 42483.246061228565 38484.06386629861 35957.32629421634 37797.640108093394 33924.39352316585 1.1365583981065888 1.230169887590142 1.210051372540492 1.2548915325866423 1.2234196927144585 1.2522919837083648 1.1344068344219365 1.0599253976246406 1.1141729057671328 1.0 15.050035403920418 -7.5108113212912535 3.2637396001605463 1.0659492748038646 1.2197454808452444 0.7577422748087035 0.04054804282454762 0.1210933655487543 2.6747818018479266 0.01976450551750283 0.011434893754313837 3.0845277285108466e-08 7.5108113212912535 0.15379620604137978 SATT(ph)TGSPGTEK ddPTM_A459_Selumetinib_30min_R2 2 SATTTGSPGTEK 12 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 SAT(0.067)T(0.354)T(0.354)GS(0.224)PGTEK;SAT(0.119)T(0.4)T(0.4)GS(0.077)PGT(0.003)EK 129.76 0.005293 9039800.0 53156.0 34080.0 42354.0 53184.0 54126.0 40391.0 59852.0 80485.0 48639.0 74047.0 True False 50201.802320327675 36693.826415528456 39628.98975154849 45940.2474524827 47326.207987420625 45954.493617008135 62635.236594488066 80719.19802499097 58368.15908720924 71909.07071278917 0.6981289261939967 0.5102809152142525 0.5510986216165967 0.6388658203632179 0.6581396132408032 0.6390639339584046 0.8710338761664496 1.122517607651894 0.8116939700185606 1.0 16.13388614530391 -7.331284883461051 3.021936931921068 0.9791687514105994 0.6072806590904185 0.7866271387509828 0.08673066592218419 0.11288378078402102 2.025850113067286 0.03881719595954894 0.025134047794638056 4.6635336688081155e-08 7.331284883461051 -0.37188809232018094 SATTT(ph)GSPGTEK ddPTM_A459_Selumetinib_30min_R1 2 SATTTGSPGTEK 12 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 SAT(0.005)T(0.063)T(0.869)GS(0.063)PGTEK;SAT(0.012)T(0.163)T(0.636)GS(0.189)PGTEK 222.73 4.4574e-08 28435000.0 6359.7 8844.099999999999 9148.3 8966.8 7829.2 8590.1 6505.6 8330.4 5188.5 6352.799999999999 True False 6507.868636177976 7808.628660489457 7906.011108014875 7400.916707682467 7121.050242357529 8503.691393186755 6014.877354311391 8109.450731047253 8804.505546953407 7168.243761512205 0.9078749066989155 1.0893363730758727 1.102921631999165 1.0324588496026783 0.9934163065982677 1.1863005327532032 0.8391005599734933 1.1313023106982751 1.2282653659501135 1.0 12.80740398282006 -7.946764567302499 24.999999821901575 1.1360237780924816 1.0296094044395978 0.14435881063058464 0.10627137429210497 155.23528113661882 72899.8866145215 0.05517362387816576 0.026504548464589966 1.130408547393854e-08 7.946764567302499 -0.10641437365288375 SATTT(ph)GSPGTEK ddPTM_A459_Selumetinib_30min_R2 2 SATTTGSPGTEK 12 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 SATT(0.002)T(0.78)GS(0.218)PGTEK;S(0.001)AT(0.137)T(0.048)T(0.633)GS(0.182)PGTEK 201.48 0.00018366 36318600.0 83545.0 56456.9 63530.0 88130.0 86595.0 66978.0 102431.0 129358.0 74498.0 114981.0 True False 78901.90335713324 60786.962692454465 59442.548966234004 76126.54196727007 75716.16193087764 76203.61153425198 107194.24446317596 129734.41036363039 89399.68164803789 111661.19977348424 0.7066188032834461 0.5443875116492283 0.5323473962918102 0.6817636038453847 0.6780883788144435 0.6824538128628254 0.959995456619041 1.1618575711778973 0.8006333608217892 1.0 16.76876843717185 -7.232655984031621 3.284347634235525 1.0006377936395534 0.6257756853587946 0.7518450688724847 0.09692240268711975 0.1193327620258734 2.6612659797518727 0.04131110544781383 0.0292096533167364 5.8525349511409924e-08 7.232655984031621 -0.37486210828075883 SATTTGS(ph)PGTEK ddPTM_A459_Selumetinib_30min_R1 1 SATTTGSPGTEK 12 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 SATT(0.002)T(0.025)GS(0.974)PGTEK 237.07 3.7473e-13 49328000.0 3085.3 4207.8 4441.9 3618.1 3659.0 4036.3 3348.8 3855.4 2530.0 3374.7 True False 3157.181487051262 3715.1488198468523 3838.714377610185 2986.2667551485383 3328.044096048919 3995.6984866671787 3096.1973198656524 3753.1422678958475 4293.225216111039 3807.875617361676 0.8291188589922341 0.9756486800430024 1.0080986784620543 0.7842343225532147 0.8739897072464743 1.0493248436081106 0.8131035860911032 0.9856262769675888 1.127459415044035 1.0 11.894770639057361 -8.00010577692446 24.99997908716354 1.061334107160175 0.9103779241258093 0.35443593768134485 0.08634346294619745 3.833294696756737 905816.1136172723 0.047315670781500424 0.022345641608736307 9.997564692889737e-09 8.00010577692446 -0.15095618303436564 SAVAVYSYSCEGPEEES(ph)EDDSHLEGR ddPTM_A459_Selumetinib_30min_R1 1 SAVAVYSYSCEGPEEESEDDSHLEGR 26 0 A0A1B0GTI3;A0A1B0GTY1;A0A1B0GUC3;A0A1B0GV98;A0A1B0GTC5;A0A1B0GU26;A0A1B0GTC3;A0A1B0GVH5;Q9C0B1 A0A1B0GTI3 FTO Alpha-ketoglutarate-dependent dioxygenase FTO 1 SAVAVYSYSCEGPEEES(0.714)EDDS(0.286)HLEGR 167.06 3.3137e-17 11344000.0 2934.5 3624.2 1928.1 1694.3 2171.7 2686.2 3287.9 2657.1 1732.9 3086.4 True False 3002.8681404569816 3199.8769791551304 1666.2746102951899 1398.4223109499926 1975.2701184447758 2659.1792668744565 3039.891055896522 2586.625076522814 2940.604733991631 3482.569504081867 0.8622564853156169 0.9188264513901598 0.478461264977533 0.40154900262892756 0.5671875654253538 0.7635681825610868 0.8728874046400257 0.7427346599948889 0.844377902736756 1.0 11.76593643065261 -6.960791948694951 4.98373228973781 0.8410889768234127 0.6387001911436712 0.2935167953431035 0.15863217809883037 0.30557508452729965 18.05817180186962 0.06499607654091481 0.0559863810668069 1.0944805579995691e-07 6.960791948694951 -0.2023887856797415 SAVCIADPLPT(ph)PSQEK ddPTM_A459_Selumetinib_30min_R1 2 SAVCIADPLPTPSQEK 16 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 1 SAVCIADPLPT(0.515)PS(0.485)QEK;SAVCIADPLPT(0.805)PS(0.195)QEK 145.46 0.00087682 6281600.0 5484.5 6637.4 4946.6 5077.4 4797.9 5881.5 6012.0 6072.3 3081.6 6321.5 True False 5612.278179020721 5860.290122356455 4274.878889728844 4190.727404602193 4363.930792138045 5822.337449974726 5558.509999711029 5911.242878389781 5229.25012884102 7132.926101624386 0.786812887034205 0.8215829014437549 0.5993163014481985 0.5875186907723375 0.6118009257300793 0.8162621295976697 0.7792748614688698 0.8287262189697451 0.7331143004061348 1.0 12.80027831172513 -6.7809184305844745 24.415546303555153 0.8175084311508344 0.6794174032534418 0.3724361555195794 0.0965365808451561 236.18342618732697 296035.92015783564 0.03574235308755024 0.03157157289843726 1.656080980252206e-07 6.7809184305844745 -0.13809102789739258 SAVCIADPLPT(ph)PSQEK ddPTM_A459_Selumetinib_30min_R2 1 SAVCIADPLPTPSQEK 16 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 1 SAVCIADPLPT(0.858)PS(0.142)QEK 195.38 2.9388e-06 5851300.0 48699.0 41091.0 42672.0 52189.0 45419.0 43851.0 50631.0 47612.0 37562.0 42036.0 True False 45992.50453754305 44242.547571610325 39926.52997776068 45080.76816895339 39713.059168988235 49891.07721025537 52985.44182342319 47750.543037409116 45075.449569969634 40822.3114573555 1.1266511595157596 1.083783499565617 0.9780565713303474 1.1043168933745076 0.9728273032866835 1.2221521866142597 1.2979530049094292 1.1697167880190005 1.1041866068034174 1.0 15.317070253092352 -6.7719635546193375 24.99985205962969 1.1781059781472671 1.053503507908945 0.258820115411577 0.08637705175922528 252.7223904493153 600330.5248274575 0.030095539526200497 0.026815735328357695 1.690582797015589e-07 6.7719635546193375 -0.12460247023832216 SAVCIADPLPTPS(ph)QEK ddPTM_A459_Selumetinib_30min_R2 1 SAVCIADPLPTPSQEK 16 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 1 SAVCIADPLPT(0.227)PS(0.773)QEK 224.15 2.7698e-11 4541900.0 60616.0 39477.0 47976.0 50892.0 48001.0 53680.0 53146.0 54450.0 39666.0 48146.0 True False 57247.20538507383 42504.758961438296 44889.276392319254 43960.42180640322 41970.68524561536 61073.932741477 55617.39430680112 54608.44048531726 47600.30836064148 46755.89988166899 1.22438463445162 0.909077978800759 0.9600772631031841 0.9402112229185912 0.8976553836379114 1.3062294362004463 1.1895267644844612 1.1679475878663799 1.018059934278017 1.0 15.512860802153527 -6.745040607014766 24.999999385360102 1.1501728887015439 0.9779769983847987 0.28222970695054883 0.1182734783447193 285.13318553550084 434686.0973034911 0.03873631437521414 0.03863007361370591 1.798702726570136e-07 6.745040607014766 -0.1721958903167452 SAVEAQNEVT(ph)ENPK ddPTM_A459_Selumetinib_30min_R1 1 SAVEAQNEVTENPK 14 0 Q32MZ4-2;Q32MZ4;Q32MZ4-3 Q32MZ4-2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 1 SAVEAQNEVT(1)ENPK 119.22 0.0052475 34173000.0 1344.2 1004.2 1304.5 1424.0 1507.4 1130.6 1462.0 1172.9 950.72 953.75 True False 1375.517244642111 886.627797160086 1127.3560651055827 1175.3251317905872 1371.0559361530852 1119.2271905026662 1351.7201629370468 1141.7908818838623 1613.302402158533 1076.1731028117154 1.2781561266011014 0.8238709877096865 1.047560157524976 1.0921339036627262 1.2740105960378771 1.0400066565299426 1.2560434370691946 1.0609732569051462 1.499110503638737 1.0 10.071694439212761 -6.0090912053986525 4.106777880839465 1.1878048476698124 1.0304326137549404 0.12005029467482897 0.1693733320241504 0.39622414508107157 15.635084448713672 0.047213120479300805 0.06726641536918412 9.792843060863568e-07 6.0090912053986525 -0.15737223391487198 SAVENCQDSWR ddPTM_A459_Selumetinib_30min_R2 4 SAVENCQDSWR 11 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 ;;; 225.93 1.0601e-05 152569000.0 200770.0 189135.0 250163.0 274049.0 266191.0 185054.0 169002.0 209866.0 181785.0 223022.0 False True 189612.0071459888 203641.04633512246 234067.7849368803 236723.053439106 232749.70680226668 210543.50874704303 176860.92787110986 210476.67531481327 218147.07949728315 216582.77537925448 0.8754713149000994 0.9402458066137994 1.0807313025101286 1.0929911347963115 1.0746455086038238 0.9721156651463341 0.8165973843552963 0.9718070836715943 1.0072226617065436 1.0 17.724558985790033 -6.99437653213179 24.824126902043957 0.9391001099417343 1.0176492417035419 0.12057633738423335 0.07970967249964572 267.464274574718 1180679.1032538463 0.030597820047249355 0.026902817613089634 1.0130327082899953e-07 6.99437653213179 0.07854913176180756 SAVGHEYQSK ddPTM_A459_Selumetinib_30min_R2 1 SAVGHEYQSK 10 0 Q14247-3;Q14247;Q14247-2 Q14247-3 CTTN Src substrate cortactin 0 113.69 0.0089522 0.0 15836.0 15096.0 17993.0 19251.0 22031.0 14394.0 19653.0 27480.0 19715.0 27567.0 False True 14955.898516530771 16253.814658709442 16835.349969297153 16628.98059017269 19263.268820361074 16376.642844277563 20566.9034416807 27559.962250441116 23658.550883125285 26771.06908233227 0.558658993801671 0.6071410375402694 0.6288635660205197 0.6211548944508566 0.7195554559707138 0.611729131694835 0.7682511063876024 1.0294681234314054 0.8837357525904295 1.0 14.708387132610403 -7.552115247810861 3.34362767607022 0.9668573038746102 0.6293681784325841 0.8964908934807918 0.05253649503033594 0.07196137580136548 1.6802895303372054 0.02679081142383711 0.014995729514543813 2.8046892647138044e-08 7.552115247810861 -0.33748912544202614 SAVQKPPS(ph)TGSAPAIESVD ddPTM_A459_Selumetinib_30min_R1 2 SAVQKPPSTGSAPAIESVD 19 1 Q9NUQ3;Q9NUQ3-2 Q9NUQ3 TXLNG Gamma-taxilin 1 SAVQKPPS(0.718)T(0.226)GS(0.056)APAIESVD;SAVQKPPS(0.707)T(0.209)GS(0.084)APAIESVD 120.82 0.0057667000000000005 5222800.0 3791.4 4517.9 4971.7 5840.3 4123.3 4471.0 3836.5 4039.2 2722.7 3759.8999999999996 True False 3879.7322432198334 3988.942167685274 4296.5704475932735 4820.401241008822 3750.3482430277395 4426.025799343195 3547.1097162161277 3932.067294829306 4620.223041859891 4242.5197895274105 0.9144877185480402 0.9402294781351195 1.0127402253253563 1.1362118458251866 0.8839907482070942 1.0432540138690138 0.8360856029409949 0.9268235600304208 1.0890280472621094 1.0 12.050705673996665 SAVQKPPS(ph)TGSAPAIESVD ddPTM_A459_Selumetinib_30min_R2 2 SAVQKPPSTGSAPAIESVD 19 1 Q9NUQ3;Q9NUQ3-2 Q9NUQ3 TXLNG Gamma-taxilin 1 SAVQKPPS(0.717)T(0.251)GS(0.032)APAIESVD;SAVQKPPS(0.689)T(0.213)GS(0.097)APAIESVD 147.49 0.00019433 10219000.0 65847.0 65580.0 65085.0 56372.0 67823.0 54754.0 54832.0 52102.0 43693.0 61534.0 True False 62187.487346425914 70609.77512706444 60897.50195918996 48694.036352875926 59302.468394687014 62295.86649267568 57381.79664754676 52253.608194049564 52432.820884422676 59757.353535467526 1.0406666906611928 1.1816081360623796 1.0190796338235717 0.8148626649601336 0.9923877964155403 1.0424803443763868 0.9602466182423757 0.8744297580553949 0.8774287645335975 1.0 15.866828636682621 -5.521181166765994 24.996880817608353 0.9380382484375274 1.1084390517913363 0.48780591237012905 0.07143743899010892 50.531104497042605 744070.139499194 0.019947368592330733 0.035214680855596425 3.0117494051330484e-06 5.521181166765994 0.17040080335380892 SAVRPAS(ph)LNLNR ddPTM_A459_Selumetinib_30min_R2 1 SAVRPASLNLNR 12 1 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SAVRPAS(1)LNLNR 79.804 0.02274 20161000.0 63653.0 59479.0 73919.0 75807.0 92449.0 64894.0 74277.0 74271.0 51823.0 63596.0 True False 60115.42108314807 64040.84804487142 69163.132016922 65481.9558256309 80834.73011545364 73832.55945092038 77731.02767708334 74487.11631377412 62189.04805560241 61759.818237748106 0.9733743200430118 1.0369338814816835 1.1198726613908478 1.0602679491956113 1.3088563474114434 1.195478898054679 1.2586019501847159 1.2060773240463811 1.0069499851214256 1.0 15.91438088623761 -5.296608004564787 1.255093281555423 1.1732109016993402 0.9656384291305276 0.25120442483511674 0.09752465667834678 0.8549653974841462 2.055071859091055 0.031082576037912407 0.1810908970860267 5.051170119203942e-06 5.296608004564787 -0.20757247256881262 SAVS(ph)PDLHITPIYEGR ddPTM_A459_Selumetinib_30min_R1 1 SAVSPDLHITPIYEGR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 S(0.013)AVS(0.987)PDLHITPIYEGR 107.15 0.0022281 9814400.0 3316.0 4037.1 4273.3 4830.9 5700.6 3627.7 4600.9 3870.4 1325.6 2728.2 True False 3393.2563481872035 3564.4344552031275 3693.0093315566796 3987.274002224119 5184.981736522675 3591.2086316880614 4253.850408794158 3767.744419168983 2249.4463820066367 3078.391044918398 1.102282425680962 1.1578887812472873 1.1996556895047015 1.29524610227997 1.6843154949666632 1.1665862391381978 1.381842120355739 1.2239330105213642 0.7307214545468069 1.0 11.587960792069202 -8.160963374754983 5.5565960698473225 0.8698308601563288 1.28761971930472 0.49491362532701944 0.16661238107431464 0.18197024873164203 7.956379461703129 0.12170120217285393 0.04416952886165337 6.9029801611093335e-09 8.160963374754983 0.41778885914839126 SAVS(ph)PDLHITPIYEGR ddPTM_A459_Selumetinib_30min_R2 3 SAVSPDLHITPIYEGR 16 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 SAVS(1)PDLHITPIYEGR;S(0.044)AVS(0.956)PDLHITPIYEGR;S(0.126)AVS(0.874)PDLHITPIYEGR 143.93 0.00039053 12191100.0 58163.2 47779.8 73627.0 76389.0 85489.0 54573.6 70580.0 69236.4 62994.3 63334.3 True False 54930.72218973743 51444.35702372849 68889.91897901635 65984.68642162478 74749.10753864325 62090.61803018386 73862.10985161678 69437.86646129702 75594.92020780411 61505.67419672637 0.8931000742149593 0.8364164395496798 1.1200579439007758 1.072822748199983 1.215320513349023 1.0095104043829606 1.2008991172971824 1.1289668370953787 1.2290722960943925 1.0 15.908431891755168 -5.266314398632241 24.14875833807387 1.1270524849606582 0.8647582399015435 0.6449625764809124 0.0762961726014792 126.57384467461962 626998.3710299488 0.018659669190716287 0.04098017215137471 5.416086619017864e-06 5.266314398632241 -0.2622942450591147 SAYLPGQTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 SAYLPGQTSPK 11 0 H0YJ41;Q9P203-5;Q9P203 H0YJ41 BTBD7 BTB/POZ domain-containing protein 7 1 SAYLPGQT(0.022)S(0.978)PK;SAYLPGQT(0.406)S(0.594)PK;SAYLPGQT(0.023)S(0.977)PK 160.56 0.00060085 16146000.0 189626.0 176542.0 166128.0 160331.0 147809.0 117822.0 146173.0 133385.0 102822.0 145316.0 True False 179087.34605302257 190082.20372799932 155439.50534649036 138493.6412135983 129239.91199077429 134050.91101837365 152970.3341363046 133773.1282669244 123389.27308672125 141120.3495036894 1.2690398421124984 1.3469510555813207 1.1014676897638114 0.9813867503919241 0.9158134347406467 0.949904896705695 1.0839707715739848 0.9479364863919013 0.8743549284045348 1.0 17.106566513479287 -5.47948391174769 2.6774888840969964 0.9646459326733794 1.3100437695845324 0.8554651844190048 0.055923195988416705 0.09752723346475392 1.3720514218065516 0.016347038573370387 0.038458198809340885 3.3152485077989214e-06 5.47948391174769 0.345397836911153 SAYPPPAPAYALS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 2 SAYPPPAPAYALSSPR 16 0 O14497-2;O14497 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 SAYPPPAPAYALS(0.5)S(0.5)PR;SAYPPPAPAYALS(0.5)S(0.5)PR 172.42 6.3115e-06 14119400.0 3409.8 3805.2 4046.3 4504.799999999999 4431.3 3203.0 4002.3 3782.6 1943.04 3014.5 True False 3489.2417056841755 3359.6854150105123 3496.8346847349335 3718.121245568985 4030.489697409559 3170.780728091312 3700.4032887297863 3682.273160383574 3297.196965973278 3401.440438716557 1.025812966168165 0.9877243113738603 1.0280452495750216 1.093101970344046 1.1849361380940002 0.9321876379195756 1.0878930133864213 1.0825628808520258 0.9693531388770658 1.0 11.731930111528635 -5.528086499279934 24.161127998515205 1.0561088975249124 1.0070476647716706 0.056572419256874285 0.06814085834987568 229.52290228396845 1064852.3458480805 0.018438323043010785 0.03207990637023727 2.964240937070303e-06 5.528086499279934 -0.04906123275324181 SAYPPPAPAYALS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 SAYPPPAPAYALSSPR 16 0 O14497-2;O14497 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 SAYPPPAPAY(0.001)ALS(0.698)S(0.301)PR 119.45 0.0016826 5734600.0 27075.0 26194.0 30502.0 35309.0 40767.0 22499.0 22665.0 25658.0 27544.0 29386.0 True False 25570.279889812475 28202.99557301502 28539.534528066582 30499.853288577615 35645.484998395914 25598.033024413013 23718.967409845485 25732.660532089434 33053.569643662326 28537.549826002683 0.896022259994917 0.9882767001712661 1.0000695470380603 1.0687621563357528 1.249073070944467 0.8969947728689988 0.831149399807035 0.9017123295091891 1.1582483375480526 1.0 14.800573852918891 -9.855031230012209 15.233951202786416 0.9999999999999987 0.997263638215529 0.0 0.12310661839356575 0.0 0.0 0.12642912569547554 0.03066356702334927 1.396267952151666e-10 9.855031230012209 -0.0027363617844696764 SAYQEYDS(ph)DSDVPEELKR ddPTM_A459_Selumetinib_30min_R2 4 SAYQEYDSDSDVPEELKR 18 1 H0Y7Q2;Q96JG6-3;Q96JG6 H0Y7Q2 CCDC132 Coiled-coil domain-containing protein 132 1 SAYQEYDS(0.997)DS(0.002)DVPEELKR;SAYQEYDS(0.726)DS(0.273)DVPEELKR;S(0.003)AY(0.001)QEY(0.001)DS(0.695)DS(0.3)DVPEELKR;SAYQEY(0.001)DS(0.997)DS(0.002)DVPEELKR 100.39 0.0014368 103003200.0 211842.0 168376.0 191138.0 183085.0 220611.0 153230.0 198834.0 189970.0 152438.0 188516.0 True False 200068.66971071676 181289.89778582816 178840.3891753189 158148.50716075877 192895.87389263645 174336.0416165522 208080.1749820963 190522.78124877333 182929.8594735912 183073.0532566091 1.0928351614384522 0.990259869275892 0.9768799175739022 0.8638546435290277 1.0536551964436784 0.9522758183979679 1.1365964093603405 1.0406926517018436 0.9992178325511555 1.0 17.482059929176565 -7.210107345431251 24.99996982349811 1.0475183627049212 0.9851787048280035 0.14153136484380602 0.06689410009183282 646.6363082777498 314928.34312867146 0.025726287985027754 0.01992742350535173 6.164426156815444e-08 7.210107345431251 -0.06233965787691764 SAYS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 SAYSER 6 0 Q96PF2;Q9BXA7 Q96PF2 TSSK2;TSSK1B Testis-specific serine/threonine-protein kinase 2;Testis-specific serine/threonine-protein kinase 1 1 SAYS(1)ER 91.9 0.044378 3924500.0 46734.0 37615.0 39399.0 47199.0 52012.0 37421.0 37918.0 59545.0 35250.0 60946.0 True False 44136.71137102479 40499.94954871195 36864.11123438775 40770.41477718357 45477.78756682037 42575.40307598381 39681.2621330916 59718.26609179462 42300.98496729221 59186.33062327501 0.7457247460052547 0.6842787704900455 0.622848398374792 0.6888484950467704 0.7683832920187189 0.719345203996158 0.6704463972545538 1.0089874716495844 0.7147086923928573 1.0 15.852976396296588 -8.293172132254751 0.4662936696530908 0.9996845018726754 0.6741791038133181 0.4915157095797267 0.09052027764303854 0.7968529583474104 0.45801198425050826 0.10302497236378429 0.058227447498770714 5.0912903819313296e-09 8.293172132254751 -0.3255053980593573 SCAS(ph)SYQR ddPTM_A459_Selumetinib_30min_R2 1 SCASSYQR 8 0 J3KNG8;Q8TF40;A0A087WX11;Q8TF40-3;Q8TF40-2 J3KNG8 FNIP1 Folliculin-interacting protein 1 1 SCAS(0.596)S(0.404)YQR 105.4 0.014171 2528700.0 14862.0 14529.0 13236.0 15488.0 15629.0 12418.0 18015.0 19249.0 17239.0 18974.0 True False 14036.02953729984 15643.327581901787 12384.410170267167 13378.50768170976 13665.545294967242 14128.46678061961 18852.733196045283 19305.01140315651 20687.281697904968 18426.171319627538 0.7617442220538065 0.8489733059867153 0.6721097918521634 0.7260600940716853 0.7416378073295519 0.7667608498554436 1.0231497834801617 1.047695208531619 1.1227118938088292 1.0 14.169468711396588 -7.28258667821599 3.6661392517032465 1.0596725496225414 0.7493175291312231 0.8961787185006265 0.04938990055700937 0.07111247048582314 2.092268223635611 0.022104177160318355 0.015114723968280033 5.2169097269344066e-08 7.28258667821599 -0.31035502049131836 SCDELS(ph)PVSPTQGGYPSEPTR ddPTM_A459_Selumetinib_30min_R2 1 SCDELSPVSPTQGGYPSEPTR 21 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 SCDELS(0.729)PVS(0.21)PT(0.06)QGGYPS(0.001)EPTR 88.471 0.00088025 8457000.0 51673.0 45463.0 58127.0 57244.0 58272.0 38196.0 31833.0 42421.0 32374.0 52485.0 True False 48801.221523408305 48949.865913414586 54387.172103892415 49447.268448592025 50951.35040171031 43457.15229123426 33313.29757589282 42544.438086825416 38849.704605138104 50969.621677593095 0.9574570090415632 0.960373342047653 1.0670507316675202 0.970132145797929 0.9996415261624196 0.852608884682748 0.6535912270766918 0.8347018613545742 0.7622129285338003 1.0 15.6373500244175 -6.861304964709069 4.23495298959747 0.7935346486506993 0.9924492016363199 0.49288099298769306 0.08592161442400101 0.16312784537535582 5.285084750653868 0.029611514004395365 0.026192121376178226 1.376242721966682e-07 6.861304964709069 0.19891455298562055 SCDEPLT(ph)PPPHS(ph)PTSMLQLIHDPVSPR ddPTM_A459_Selumetinib_30min_R2 1 SCDEPLTPPPHSPTSMLQLIHDPVSPR 27 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 2 S(0.005)CDEPLT(0.643)PPPHS(0.591)PT(0.378)S(0.378)MLQLIHDPVS(0.003)PR 67.13600000000001 0.0034388000000000005 1132300.0 3584.9 2693.7 3411.7 4783.9 5080.3 3408.8 3005.2 3691.2 4925.4 4061.0 True False 3385.665609491736 2900.2981283893464 3192.194936378096 4132.324567312199 4442.067295541756 3878.331257994535 3144.9477546908274 3701.9407808889464 5910.6176271745 3943.748378254845 0.8584892555923999 0.7354166265731087 0.8094316954852682 1.0478164859850418 1.1263566712406288 0.9834124507990902 0.7974514226190322 0.9386858455019127 1.4987309179674433 1.0 11.945351791493458 -5.289501152877202 0.4221879359984132 1.0966484370643679 0.6204390034484174 0.2634645507596991 0.17883493938520426 5.4892703328971875 1.0538101998763447 0.156616940094424 1.2629690537937592 5.134508144957245e-06 5.289501152877202 -0.4762094336159505 SCDEPLT(ph)PPPHSPTSMLQLIHDPVSPR ddPTM_A459_Selumetinib_30min_R2 2 SCDEPLTPPPHSPTSMLQLIHDPVSPR 27 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 S(0.011)CDEPLT(0.989)PPPHSPTSMLQLIHDPVSPR;S(0.096)CDEPLT(0.899)PPPHS(0.003)PT(0.001)S(0.001)MLQLIHDPVSPR 91.416 1.755e-05 6128600.0 32485.0 30316.0 42623.0 51040.0 59141.0 39159.0 36950.0 37685.0 35620.0 49265.0 True False 30679.613747758398 32641.139718696006 39880.68258441354 44088.26395108895 51711.17885275177 44552.7967999906 38668.248215035994 37794.65711091241 42744.99530595599 47842.59144415786 0.6412615375061324 0.6822611136521509 0.8335811539590722 0.9215275055187807 1.0808607412729587 0.9312371143605981 0.8082389989298508 0.789979304424313 0.8934506684456713 1.0 15.546007916292389 -5.33434597234494 2.4650511138951723 0.9111642742657325 0.6464051169404946 0.619276133923419 0.07950941734287248 0.22560438418439435 2.612497364586578 0.02496002245271751 0.07397813619882203 4.630778706799567e-06 5.33434597234494 -0.2647591573252379 SCDEPLTPPPHS(ph)PTSMLQLIHDPVSPR ddPTM_A459_Selumetinib_30min_R1 1 SCDEPLTPPPHSPTSMLQLIHDPVSPR 27 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 SCDEPLT(0.001)PPPHS(0.558)PT(0.22)S(0.22)MLQLIHDPVSPR 72.271 0.00020564 17007000.0 1913.1 2627.7 2376.0 2589.7 2923.2 2130.5 2631.7 2212.1 987.98 1880.8 True False 1957.6715077554106 2320.0476624154103 2053.3522504337802 2137.4575096896633 2658.7970761328784 2109.0691043392276 2433.188750206173 2153.4279220865296 1676.529900795804 2122.219000543407 0.9224644144898038 1.0932178355868776 0.9675496496393665 1.007180460236363 1.252838220490947 0.9938037044240898 1.146530470975493 1.0147057968735231 0.7899891106273755 1.0 11.051357826256528 -8.019420287823891 22.233433628622564 0.8974452763732861 1.0580921586680674 0.2792258357338576 0.10117475627548293 223.18708991415593 255511.6653858348 0.0636292748037989 0.02499698898895322 9.562681962684756e-09 8.019420287823891 0.1606468822947813 SCDEPLTPPPHS(ph)PTSMLQLIHDPVSPR ddPTM_A459_Selumetinib_30min_R2 2 SCDEPLTPPPHSPTSMLQLIHDPVSPR 27 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 SCDEPLTPPPHS(0.429)PT(0.142)S(0.429)MLQLIHDPVSPR;S(0.001)CDEPLT(0.029)PPPHS(0.887)PT(0.064)S(0.019)MLQLIHDPVSPR 100.14 6.6021e-07 19972100.0 37155.0 37887.0 48826.0 56187.0 61060.0 44642.0 36395.0 43046.0 43147.0 48528.0 True False 35090.073843249585 40792.81107409406 45684.58831772929 48534.23367201873 53389.09691667411 50791.030280272236 38087.43961532434 43171.25673335107 51777.605627907964 47126.87054911381 0.7445873964128397 0.8655955848284338 0.9693957562940355 1.0298632840777793 1.1328801657015195 1.0777509664542606 0.8081894505520174 0.9160645769669693 1.0986854213870902 1.0 15.524262262193304 -5.011152384826808 1.8912544041507593 1.0047779817533133 0.7227619389231157 0.47756291729491684 0.0884245869366161 0.5037144195098433 2.67153320601063 0.0270796985491515 0.21471138602665285 9.746475943098925e-06 5.011152384826808 -0.28201604283019766 SCDEPLTPPPHSPT(ph)SMLQLIHDPVSPR ddPTM_A459_Selumetinib_30min_R2 1 SCDEPLTPPPHSPTSMLQLIHDPVSPR 27 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 SCDEPLT(0.049)PPPHS(0.276)PT(0.337)S(0.337)MLQLIHDPVS(0.001)PR 62.677 0.023544 2619900.0 4985.3 4246.5 5098.1 7843.8 8705.0 5291.9 3937.0 6106.4 4217.6 6021.3 True False 4708.236983737104 4572.192895350398 4770.093796391589 6775.460908690278 7611.400076312615 6020.811189914713 4120.078301017499 6124.168613031058 5061.237849590117 5847.449423783777 0.8051778891129752 0.7819123457064151 0.8157563153927972 1.1587036360044312 1.3016615492823567 1.0296474160897928 0.704594089221121 1.0473230581733226 0.8655462378185192 1.0 12.513591763023136 -5.652926269302545 8.19152699815517 1.0166281795258612 0.7954149687107106 0.3022128738737959 0.1494605116403251 0.33376904401459995 23.04385844223277 0.04488290504484627 0.07789355033257919 2.2236873766925324e-06 5.652926269302545 -0.22121321081515055 SCDS(ph)PLNLK ddPTM_A459_Selumetinib_30min_R2 2 SCDSPLNLK 9 0 Q8N1G0 Q8N1G0 ZNF687 Zinc finger protein 687 1 S(0.109)CDS(0.891)PLNLK;S(0.09)CDS(0.91)PLNLK 95.477 0.022341 10452600.0 86453.0 87948.0 89955.0 88584.0 102359.0 70306.0 77049.0 76738.0 62589.0 80037.0 True False 81648.28835877965 94693.32880260823 84167.39323559856 76518.70638407656 89499.74731892956 79990.01332567596 80631.93116969719 76961.29487534029 75108.5488827759 77726.12384889995 1.0504613418971518 1.2182947523112386 1.082871357372979 0.9844657445266328 1.151475757274576 1.0291264939594444 1.037385208175904 0.9901599496322948 0.9663230991524466 1.0 16.246111951321808 -6.867791479150053 0.5532117918350588 0.974983524024144 1.1251226089263557 0.376018373128574 0.059983491587925465 0.9565364747040107 0.6294771863041818 0.05287139349924128 0.05817300915309774 1.35584024516277e-07 6.867791479150053 0.15013908490221173 SCFES(ph)SPDPELK ddPTM_A459_Selumetinib_30min_R1 3 SCFESSPDPELK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SCFES(0.5)S(0.5)PDPELK;SCFES(0.5)S(0.5)PDPELK;SCFES(0.904)S(0.096)PDPELK 262.15 2.7606e-25 1793230000.0 41958.7 46976.0 52272.0 53809.0 43582.5 39882.8 44161.6 41700.9 24707.9 36725.8 True False 42936.25607258214 41476.0280814501 45173.74950954314 44412.26827002785 39640.47057011533 39481.61524268507 40830.45495729186 40594.856668386674 41927.50170638341 41439.91416958588 1.0361087114435792 1.000871476512148 1.0901023907693719 1.0717268401734164 0.9565770432799009 0.9527436538867624 0.985292942215085 0.9796076435452798 1.011766132883436 1.0 15.338733394464818 -6.261648571398409 24.99985405716204 0.9787803236439653 1.04910015261214 0.6029323646284119 0.02727685074728101 13.899811343888873 1661090.0327378912 0.008846517485655452 0.010710520685460917 5.474587842109483e-07 6.261648571398409 0.07031982896817468 SCFES(ph)SPDPELK ddPTM_A459_Selumetinib_30min_R2 3 SCFESSPDPELK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SCFES(0.943)S(0.057)PDPELK;SCFES(0.5)S(0.5)PDPELK;SCFES(0.5)S(0.5)PDPELK 287.29 8.3787e-56 1957600000.0 4275680.0 3919590.0 4318490.0 4303300.0 4262230.0 3222140.0 3957780.0 3563530.0 3022920.0 3643320.0 True False 4038054.8225031737 4220209.949531721 4040643.0550164 3717183.116393444 3726770.562580344 3665960.537325313 4141824.612192294 3573899.2823258527 3627588.4674418936 3538127.885117811 1.141297023063573 1.1927805004683143 1.142028549056207 1.0506073372951783 1.053317088468172 1.036130025922804 1.17062603350596 1.010110261236883 1.0252847226637496 1.0 21.754554764297396 -1.5228787463892202 0.1902111926818066 0.9991971249398214 1.8252656645653789 0.506617680666196 0.04777794505942684 47.32880733137637 0.553584365873009 0.10211035696528958 11.478685710096402 0.029999999923401105 1.5228787463892202 0.8260685396255575 SCFESS(ph)PDPELK ddPTM_A459_Selumetinib_30min_R1 1 SCFESSPDPELK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SCFES(0.044)S(0.956)PDPELK 301.93 1.7695999999999991e-69 1400300000.0 16446.0 18130.0 19835.0 20225.0 16105.0 15314.0 16818.0 15524.0 9312.8 13223.0 True False 16829.15980165462 16007.331171591664 17141.515945856063 16693.083420270097 14648.305593568695 15159.955063999487 15549.404719750526 15112.253090941327 15803.141419999565 14920.300852927208 1.1279370280494654 1.0728557908704095 1.1488720043130414 1.1188168110561314 0.9817701223293261 1.0160622907965868 1.042164288309233 1.0128651720837425 1.0591704266405026 1.0 13.864989005936843 -6.2476950396388125 24.95128916639525 1.0203594331600778 1.1162266300897068 0.7672399282184325 0.026552984161728455 372.5767034096017 676370.6570010144 0.0077981864221475525 0.01001258230401108 5.653338112762284e-07 6.2476950396388125 0.09586719692962897 SCFESS(ph)PDPELK ddPTM_A459_Selumetinib_30min_R2 3 SCFESSPDPELK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SCFES(0.031)S(0.968)PDPELK;SCFES(0.357)S(0.643)PDPELK;SCFES(0.225)S(0.775)PDPELK 145.31 0.00068655 854366000.0 603112.0 557388.0 599788.0 613381.0 594815.0 454143.0 534420.0 533601.0 404415.0 533113.0 True False 569593.4494886274 600137.8673150981 561198.293079797 529837.4496587565 520089.0219864318 516697.07595030905 559271.5889331402 535153.6905675989 485309.3002992197 517720.6424960781 1.1001945890016203 1.159192464147582 1.0839789782653841 1.0234041414772643 1.0045746282762362 0.9980229365766948 1.0802574651780024 1.0336726926465036 0.9373960790116576 1.0 18.981814316748086 -5.631474886885486 2.8873204510437382 1.0137476457386103 1.1294674802556037 0.6446854364757963 0.036161283352709385 0.16418844520646136 2.736127105379888 0.010494641217267207 0.02055043587851373 2.3362811939672793e-06 5.631474886885486 0.11571983451699341 SCGTDSQSENEAS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 SCGTDSQSENEASPVK 16 0 H0Y398;C9JQ48;Q9H8U3 H0Y398 ZFAND3 AN1-type zinc finger protein 3 1 SCGTDSQSENEAS(1)PVK;SCGTDSQSENEAS(1)PVK 258.13 5.8813e-39 9277400.0 28606.0 24004.0 30562.0 31029.0 26630.0 24055.0 27625.0 31045.0 23274.0 26186.0 True False 27016.19303889107 25845.029614974912 28595.67419338964 26802.796671989407 23284.50132477943 27368.35790045137 28909.61723789903 31135.33581022359 27929.450329893873 25429.942140601186 1.0623772908927422 1.016322784852546 1.124488370256025 1.0539857512768909 0.9156332796999814 1.0762257243501678 1.1368337795681505 1.2243573201259168 1.098289967608774 1.0 14.634240559093682 -7.079405278146874 5.000411673924812 1.1318637644672889 1.0358856215209795 0.2029105560690584 0.07143429360328717 0.30218122085512006 13.344382582414271 0.02785946930896317 0.021667104407720374 8.329035667143215e-08 7.079405278146874 -0.09597814294630935 SCGTDSQSENEAS(ph)PVKRPR ddPTM_A459_Selumetinib_30min_R1 2 SCGTDSQSENEASPVKRPR 19 2 H0Y398;C9JQ48;Q9H8U3 H0Y398 ZFAND3 AN1-type zinc finger protein 3 1 SCGTDSQSENEAS(0.999)PVKRPR;SCGTDSQSENEAS(1)PVKRPR 69.289 0.012503 9274800.0 3822.67 3783.83 5480.6 5701.4 4087.55 3743.06 4004.11 3700.49 2003.05 3210.78 True False 3911.7307733790058 3340.8174245451546 4736.364622780882 4705.757518532899 3717.831824215568 3705.40821482656 3702.076758972544 3602.3409843144464 3399.029553016294 3622.914888645664 1.0797192022474775 0.9221352218390191 1.3073353275907216 1.2988871290575716 1.0261990520029538 1.022769876940646 1.0218503257073401 0.9943211737058198 0.9382029822640785 1.0 11.822935198327665 -6.495369259131736 24.230689776028246 0.9998096089105757 1.1486742410053974 0.3389342170690629 0.10423554069257204 662.2905043663369 583353.9855937875 0.03546023321636545 0.04009320756080954 3.196176403248657e-07 6.495369259131736 0.1488646320948217 SCGTDSQSENEAS(ph)PVKRPR ddPTM_A459_Selumetinib_30min_R2 5 SCGTDSQSENEASPVKRPR 19 2 H0Y398;C9JQ48;Q9H8U3 H0Y398 ZFAND3 AN1-type zinc finger protein 3 1 SCGTDSQS(0.001)ENEAS(0.999)PVKRPR;SCGTDSQSENEAS(0.999)PVKRPR;SCGTDSQSENEAS(1)PVKRPR;SCGTDSQSENEAS(1)PVKRPR;SCGTDSQSENEAS(1)PVKRPR 101.3 0.0004671 20085800.0 101222.0 95475.8 105741.8 123651.8 115828.1 74518.2 76963.9 92960.3 60192.96 112921.4 True False 95596.48646377098 102798.48685691656 98938.48771096693 106810.21152874714 101276.73856164797 84782.4056411314 80542.87385107472 93230.79908259388 72233.23393182468 109661.06577696769 0.8717450061829445 0.9374200964450913 0.9022207381441223 0.974003040842055 0.9235432634553083 0.7731313300708262 0.7344710110230507 0.850172286964726 0.6586953484360167 1.0 16.74269187455635 -6.756866739409206 24.681409664436877 0.7896283175122657 0.9244689332700993 0.31484166205665376 0.08618396282071247 101.56002126055989 548182.813375983 0.026873364543231686 0.026007777176132896 1.7503837007044466e-07 6.756866739409206 0.13484061575783357 SCLQCRPPS(ph)PPESSVPQQQVK ddPTM_A459_Selumetinib_30min_R2 2 SCLQCRPPSPPESSVPQQQVK 21 1 P41002 P41002 CCNF Cyclin-F 1 SCLQCRPPS(1)PPESSVPQQQVK;S(0.001)CLQCRPPS(0.998)PPESSVPQQQVK 89.01100000000002 0.0004623 3393100.0 13736.6 12239.6 11817.6 14419.099999999999 13996.1 9581.0 10963.6 10825.3 10607.400000000001 10995.5 True False 12973.174763966692 13178.337963483049 11057.268482030022 12455.193705665104 12237.784791278453 10900.69578234148 11473.429123961252 10856.79983077511 12729.176395519302 10678.03134526008 1.2149406893926578 1.2341542684581874 1.0355156418358225 1.1664316485822919 1.146071255607499 1.0208525738389258 1.0744891781062476 1.016741708254526 1.192090188157175 1.0 13.382358068688383 -1.5228787507724515 0.3519556785292343 1.057726199871229 3.209349337050691 0.3778717207170833 0.06748522277211387 64.62649710278595 0.9083553993617923 0.0554422332728206 92.44858894075921 0.029999999620618212 1.5228787507724515 2.151623137179462 SCMLTGT(ph)PESVQSAK ddPTM_A459_Selumetinib_30min_R1 1 SCMLTGTPESVQSAK 15 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4 FUBP1 Far upstream element-binding protein 1 1 SCMLT(0.356)GT(0.644)PESVQSAK 185.14 4.9749e-05 4337400.0 1362.8 1436.6 1486.2 1653.3 1513.6 1473.2 1286.9 1332.2 795.72 1348.7 True False 1394.5505884528116 1268.4022041427797 1284.3822031122397 1364.5821912846739 1376.695147247784 1458.3809455585779 1189.8280969108655 1296.8657284045362 1350.2787229106232 1521.8187824504967 0.9163709927454355 0.8334778219127675 0.8439784144627742 0.8966785053653801 0.904638031231926 0.9583144605497848 0.7818461111348318 0.8521814445713887 0.8872795752568828 1.0 10.571580858204232 -8.572014024694225 17.96995832557666 1.0000000011274126 0.8725266004247699 0.3941851986445467 0.046768609919131135 653.3068909775294 238931.4487719629 0.046589297356634564 0.012029295387098895 2.679081807694347e-09 8.572014024694225 -0.12747340070264268 SCMLTGT(ph)PESVQSAK ddPTM_A459_Selumetinib_30min_R2 2 SCMLTGTPESVQSAK 15 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4 FUBP1 Far upstream element-binding protein 1 1 S(0.242)CMLT(0.125)GT(0.625)PES(0.008)VQSAK;S(0.024)CMLT(0.449)GT(0.518)PES(0.009)VQSAK 112.12 0.0072175 32960000.0 115361.0 91800.0 120726.0 121107.0 122138.0 94407.0 89760.0 98814.0 79918.0 106159.0 True False 108949.69744667242 98840.76481647615 112958.62059653037 104612.01767877226 106793.93251242625 107410.7073085807 93934.01785606575 99101.53238046166 95903.83309549115 103093.91383579341 1.056800478253314 0.9587449068420119 1.0956866064513695 1.0147254458240558 1.0358897876602704 1.0418724375879551 0.9111499831666356 0.9612743244796123 0.9302569814959735 1.0 16.653599639945043 -7.250004430720773 24.933178520122244 0.9474431824799604 1.0325548096391859 0.5251585444476101 0.03873407766350401 531.398203524227 1158681.6519631275 0.014049978460524713 0.010786581420310056 5.62335588150655e-08 7.250004430720773 0.08511162715922549 SCPETLTHAVGMS(ph)ESPIGPK ddPTM_A459_Selumetinib_30min_R2 2 SCPETLTHAVGMSESPIGPK 20 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 SCPETLTHAVGMS(0.878)ES(0.122)PIGPK;SCPETLTHAVGMS(0.693)ES(0.307)PIGPK 99.13 0.0015652 25798000.0 200282.0 176002.0 238722.0 252410.0 269416.0 203885.0 213555.0 226377.0 172422.0 246653.0 True False 189151.12823237033 189500.7874643734 223362.88642086138 218031.32256846348 235569.55347040063 231968.308066245 223485.7306512045 227035.71959127026 206911.21787320435 239531.48700854284 0.7896712477955948 0.7911310109205596 0.9324990597703557 0.9102407591227764 0.9834596545630725 0.9684251158928926 0.9330119118879512 0.9478324642270228 0.8638163627557863 1.0 17.869855788708314 -5.27252475645487 4.564598240597694 0.9423035028569301 0.7876512552939142 0.7397411535880916 0.03610170719002331 0.08857523650248288 5.0471587395539945 0.009418114493699056 0.023106625588733064 5.3391883728061545e-06 5.27252475645487 -0.15465224756301588 SCPETLTHAVGMSES(ph)PIGPK ddPTM_A459_Selumetinib_30min_R1 3 SCPETLTHAVGMSESPIGPK 20 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 SCPETLTHAVGMS(0.248)ES(0.752)PIGPK;SCPETLTHAVGMS(0.228)ES(0.772)PIGPK;SCPETLTHAVGMS(0.463)ES(0.537)PIGPK 155.31 1.2328e-06 57145000.0 14133.1 13108.400000000001 15639.2 16526.7 15826.599999999999 12858.1 15046.3 12806.900000000001 6171.5 10244.4 True False 14462.373731774594 11573.662434070164 13515.482539976414 13640.622089581093 14395.086824413167 12728.759188220702 13911.34547715438 12467.219409325977 10472.58475147403 11559.368528906254 1.2511387361350113 1.001236564534487 1.1692232587081681 1.180049070627889 1.2453177514338865 1.101163887663083 1.2034693281355802 1.0785381033703942 0.9059824267463635 1.0 13.496774967258387 -8.047911759387663 4.19726502123311 0.9571550006264326 1.1592514077535934 0.5777057997593427 0.07173967828549481 0.15702701675538774 5.752303410123485 0.04959344228436639 0.018306531097854985 8.955467056051292e-09 8.047911759387663 0.20209640712716082 SCPETLTHAVGMSES(ph)PIGPK ddPTM_A459_Selumetinib_30min_R2 3 SCPETLTHAVGMSESPIGPK 20 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 SCPETLTHAVGMS(0.172)ES(0.828)PIGPK;SCPETLTHAVGMS(0.001)ES(0.999)PIGPK;SCPETLTHAVGMS(0.125)ES(0.875)PIGPK 205.25 1.5018e-16 98472500.0 148244.0 143090.0 171074.0 195115.0 204457.0 174397.0 177554.0 159307.0 148487.0 207542.0 True False 140005.19194775124 154064.5428931328 160067.2850912878 168540.00040785116 178771.283791229 198418.60373165738 185810.61281657653 159770.5569953064 178188.54907342774 201549.72320112502 0.6946434345039565 0.7643996749099621 0.7941826093780234 0.836220450869418 0.8869835242236201 0.984464779113871 0.9219095410573075 0.7927103766640875 0.8840922539775193 1.0 17.620776276297903 -5.588337485747698 1.1239607316797924 0.9058893598209683 0.7055548561447406 0.6423830769693524 0.05544987673423158 0.44847880340669183 1.0136605911427135 0.020971513513854654 0.07692181308740668 2.580254322432985e-06 5.588337485747698 -0.20033450367622774 SCPS(ph)FSASSEGTR ddPTM_A459_Selumetinib_30min_R1 1 SCPSFSASSEGTR 13 0 D6RCP9;D6RFG8;P27707;D6RG38 D6RCP9 DCK Deoxycytidine kinase 1 S(0.002)CPS(0.967)FS(0.027)AS(0.004)S(0.001)EGTR 118.73 0.0033659 6091700.0 872.38 1004.9 954.46 1305.5 1313.7 1407.2 1680.4 1356.2 1160.5 1079.0 True False 892.7047566440142 887.2458408346644 824.8495744734952 1077.5189322700924 1194.8760669525734 1393.044845635372 1553.6460751021978 1320.2291704415488 1969.2837404335419 1217.5001603500298 0.733227629627057 0.728743921133926 0.6774944277923971 0.8850257004979014 0.9814175848724719 1.1441845274458717 1.2760951708257078 1.0843769992292933 1.617481298620425 1.0 10.249706246978885 -6.474278154474994 1.1094853918990817 1.2636880746905836 0.7050791614208449 0.6829538449627198 0.15380145592259714 0.26617577891731514 0.6927330726705305 0.06793422597881608 0.08177250576384759 3.355226517598105e-07 6.474278154474994 -0.5586089132697387 SCPS(ph)TPSSGATVDSGK ddPTM_A459_Selumetinib_30min_R1 1 SCPSTPSSGATVDSGK 16 0 Q7RTP6;J3KRP8;J3QQT0 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 S(0.001)CPS(0.471)T(0.471)PS(0.042)S(0.011)GAT(0.005)VDSGK 198.87 8.0262e-21 0.0 809.75 942.97 851.63 789.8 1083.4 985.06 1051.3 728.94 640.32 712.27 True False 828.61559950078 832.5666340251406 735.983323668737 651.8762563821665 985.4066612898054 975.1511907629181 971.9995945935136 709.6061432691811 1086.5762728775574 803.6967925973273 1.0310052337311462 1.0359213097448279 0.9157474938903775 0.811097247601899 1.2260925642184557 1.2133321916235316 1.2094108170474065 0.8829276784543695 1.3519728868968623 1.0 9.650507514163216 -6.273056378954624 24.990088704088183 1.147843955663613 0.9523558994609064 0.3421033399784612 0.13504526106550538 887.004989399376 1908090.8074602755 0.041456644570095555 0.04738881095549986 5.332656638637361e-07 6.273056378954624 -0.1954880562027067 SCPSFSASSEGT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 SCPSFSASSEGTR 13 0 D6RCP9;D6RFG8;P27707;D6RG38 D6RCP9 DCK Deoxycytidine kinase 1 S(0.005)CPS(0.223)FS(0.006)AS(0.255)S(0.255)EGT(0.256)R 103.14 0.020427 6898700.0 811.81 1138.9 1244.5 1245.6 985.3 1152.2 1192.9 1051.8 767.34 992.38 True False 830.7235934927178 1005.5570585397544 1075.503735549174 1028.079342807833 896.1797889688436 1140.6099141138968 1102.9185925906997 1023.9028472720995 1302.1199357038133 1119.7616395997804 0.7418753814335262 0.8980099183422247 0.9604756025876857 0.9181233813075468 0.8003308537066439 1.0186184932371571 0.9849583639826235 0.9143935736520298 1.1628545662353735 1.0 10.12897594733313 -2.0837714528911726 0.21643261035011918 1.0476730530176093 7.823474233526536e-21 0.4490743039567797 0.08250057628545483 41.179138934262454 0.6448910734152818 0.1358212135828375 14.256219520563684 0.008245719311462363 2.0837714528911726 -1.0476730530176093 SCPST(ph)PSSGATVDSGK ddPTM_A459_Selumetinib_30min_R1 1 SCPSTPSSGATVDSGK 16 0 Q7RTP6;J3KRP8;J3QQT0 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 SCPS(0.004)T(0.877)PS(0.087)S(0.023)GAT(0.01)VDSGK 184.51 1.8586e-13 0.0 783.91 1328.8 846.71 1173.5 1000.2 913.94 1026.4 952.53 681.73 758.26 True False 802.1735777766678 1173.223478257639 731.7314326451116 968.5702543232121 909.7320865996521 904.7465933911254 948.977821640619 927.2658101465042 1156.8460184108217 855.5900570778625 0.9375676717379926 1.3712448719479104 0.8552360170526394 1.1320494509148649 1.0632803397770931 1.0574533749038058 1.1091501283707155 1.0837734759487965 1.3521031583301155 1.0 9.740775906630406 -8.059696581941596 24.99544641676877 1.1900139821040059 1.0803613293645968 0.06488706320403193 0.14912406787834043 637.9912137037606 267127.52144987835 0.09223586047660823 0.03486205145840084 8.71572297706535e-09 8.059696581941596 -0.10965265273940905 SCPST(ph)PSSGATVDSGK ddPTM_A459_Selumetinib_30min_R2 1 SCPSTPSSGATVDSGK 16 0 Q7RTP6;J3KRP8;J3QQT0 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 SCPS(0.007)T(0.927)PS(0.05)S(0.015)GATVDSGK 153.41 0.0012637 0.0 6220.5 6994.2 5509.1 8118.1 8404.7 8009.7 6594.2 6020.4 6809.0 6638.6 True False 5874.789512634479 7530.632650102383 5154.650503854555 7012.400775496386 7348.826447028674 9112.96347018272 6900.843366159409 6037.918367269128 8170.990259355819 6446.926368845761 0.9112543212877247 1.1680965811077886 0.7995516326607943 1.0877122483332884 1.1398961344651415 1.4135361486708398 1.0704082800615133 0.9365576744364368 1.2674241633720922 1.0 12.654395791042116 -5.98729040044299 24.946274811883697 1.142344457940392 0.9743389710529902 0.21549954467806476 0.15134500881486868 370.1624885997797 726544.5401063729 0.04295946274173911 0.06367505580693553 1.029697360673591e-06 5.98729040044299 -0.1680054868874019 SCQGACGPS(ph)PPDQK ddPTM_A459_Selumetinib_30min_R1 2 SCQGACGPSPPDQK 14 0 P18754-2 P18754-2 RCC1 Regulator of chromosome condensation 1 SCQGACGPS(1)PPDQK;SCQGACGPS(1)PPDQK 209.66 5.0048e-06 7099000.0 1904.27 2124.09 2238.5299999999997 2305.67 2050.41 1921.92 2162.83 1981.29 1112.72 1605.33 True False 1948.6357859355992 1875.4005553373502 1934.5499213651203 1903.028017286238 1864.9507775292877 1902.5872297637393 1999.6859917955765 1928.7397530630712 1888.2045701466714 1811.3897427383806 1.0757683672149627 1.0353379568674166 1.0679920923260564 1.0505900372436263 1.0295690284245156 1.0503466950671203 1.1039512616277365 1.0647845174099781 1.042406570820129 1.0 10.822881277897066 SCQGACGPS(ph)PPDQK ddPTM_A459_Selumetinib_30min_R2 3 SCQGACGPSPPDQK 14 0 P18754-2 P18754-2 RCC1 Regulator of chromosome condensation 1 SCQGACGPS(1)PPDQK;SCQGACGPS(1)PPDQK;S(0.001)CQGACGPS(0.999)PPDQK 142.4 0.00039595 6562800.0 42389.0 33610.7 43417.0 43572.0 41511.0 30327.3 32512.800000000003 36770.0 28662.7 37535.3 True False 40033.18907661168 36188.53261456578 40623.59748885536 37637.41843410754 36296.017066951485 34504.61029118096 34024.70962289101 36876.99461239882 34396.040902751934 36451.55836057846 1.0982572728607034 0.9927842386487065 1.1144543420340807 1.0325324931735034 0.9957329315776197 0.9465880703881487 0.9334226341249642 1.0116712774694554 0.943609613682538 1.0 15.15369287286764 -6.279387358107854 2.623077605026489 0.9664047881401294 1.0617592602284092 0.5726365734732699 0.03812294826000839 0.20436849335366578 2.7893838587760174 0.011997232508830722 0.014953258080193677 5.2554830760698e-07 6.279387358107854 0.09535447208827974 SCQKS(ph)PAQQEPPQR ddPTM_A459_Selumetinib_30min_R2 1 SCQKSPAQQEPPQR 14 1 A0A669KBI3;F5GXF9;P51825;P51825-3;P51825-2 A0A669KBI3 AFF1 AF4/FMR2 family member 1 1 S(0.003)CQKS(0.997)PAQQEPPQR 87.419 0.012145 5697700.0 21797.0 22859.0 26307.0 25663.0 21439.0 15168.0 14814.0 15556.0 9765.3 23370.0 True False 20585.610000304438 24612.211796730182 24614.436260895927 22167.65512885573 18745.641152908225 17257.254318605108 15502.880353384116 15601.265384565564 11718.632865279387 22695.247377447846 0.9070449710435964 1.0844654560226215 1.0845634705597071 0.9767531836151572 0.8259721007287048 0.7603906682133615 0.683089287177775 0.6874243371353803 0.5163474391966371 1.0 14.47010259323932 -6.438508165927012 1.7065010644587306 0.7004153549132301 1.0334680428801284 0.5473735227406054 0.12146675295210173 0.2487676210330111 1.450955948126444 0.04413382316368012 0.051444663150598945 3.6432739965006414e-07 6.438508165927012 0.33305268796689824 SCS(ph)ASCVPHGAK ddPTM_A459_Selumetinib_30min_R1 2 SCSASCVPHGAK 12 0 P00519;P00519-2 P00519 ABL1 Tyrosine-protein kinase ABL1 1 S(0.006)CS(0.992)AS(0.002)CVPHGAK;S(0.017)CS(0.98)AS(0.003)CVPHGAK 119.21 0.003634000000000001 3526300.0 2012.99 1967.67 2110.5 2577.7 2585.1000000000004 2227.9 2406.2 1975.6100000000001 967.56 1406.19 True False 2059.8887504033055 1737.2942816550344 1823.9056921466724 2127.5530844217665 2351.278161436475 2205.48934877135 2224.698396757265 1923.2104051143117 1641.8786522135954 1586.6881839505186 1.2982316067134358 1.0949185222578128 1.1495048054152217 1.340876617058185 1.4818779046947264 1.3899954452803367 1.4021018239502079 1.2120909606359604 1.0347834368600792 1.0 10.63180292218101 -8.177847847350673 3.0680963320718075 1.006597303263474 1.305106994460596 0.5253117039442885 0.10906222619614535 0.24356995459329847 4.150867748148577 0.10811488195592336 0.03357303709682262 6.639756498234705e-09 8.177847847350673 0.2985096911971219 SCS(ph)ASCVPHGAK ddPTM_A459_Selumetinib_30min_R2 1 SCSASCVPHGAK 12 0 P00519;P00519-2 P00519 ABL1 Tyrosine-protein kinase ABL1 1 S(0.15)CS(0.461)AS(0.389)CVPHGAK 80.37100000000002 0.026638 4360700.0 37642.0 24081.0 34152.0 47008.0 42822.0 26322.0 29328.0 36532.0 28723.0 40490.0 True False 35550.008332865036 25927.935267380883 31954.697501886094 40605.429306676946 37442.31752646281 29947.6165726743 30691.81011232952 36638.30207180185 34468.402587674704 39320.948494345925 0.904098443555523 0.6593924170244555 0.8126634459614054 1.0326665775245916 0.9522231522936623 0.7616198926885133 0.7805460266743766 0.9317756431300273 0.8765913312755164 1.0 15.263010502132953 -14.522878744387418 0.1207876574141805 1.4640040808925667 0.7867026173434586 0.16257507619109568 0.10129285234855151 314.5426003414255 2.4488238388793224 35.76295338705183 1.0457933282981777 3.0000000061680705e-15 14.522878744387418 -0.6773014635491081 SCS(ph)FSSESR ddPTM_A459_Selumetinib_30min_R1 2 SCSFSSESR 9 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.002)CS(0.807)FS(0.178)S(0.013)ESR;S(0.001)CS(0.993)FS(0.006)SESR 145.99 0.0017932000000000004 50642000.0 6753.1 7641.4 8456.9 8139.099999999999 7359.299999999999 6832.4 7507.1 6994.200000000001 4026.8 5429.0 True False 6910.43409075483 6746.741335609513 7308.499430426527 6717.7589748291875 6693.652614389944 6763.672259322852 6940.833402999118 6808.691095636553 6833.185494164403 6125.865032938194 1.1280748194088643 1.1013532455143764 1.1930559016774644 1.0966220996885232 1.092686923136375 1.1041170876203164 1.1330372715818773 1.1114660638174148 1.115464584580792 1.0 12.580697866020152 -14.52287874526189 0.29909517749453923 0.013633356034890047 1.1255599909072447 0.6365000887207193 0.027242977955022837 175.64030099424687 1.6266029136785665 108.56163354451559 0.028002018446867703 3.0000000001274316e-15 14.52287874526189 1.1119266348723547 SCS(ph)FSSESR ddPTM_A459_Selumetinib_30min_R2 3 SCSFSSESR 9 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.001)CS(0.99)FS(0.007)S(0.002)ESR;SCS(0.998)FS(0.001)SESR;SCS(1)FSSESR 161.51 0.00092557 98609000.0 83977.0 70555.0 91674.0 94126.0 96648.0 77228.0 82639.0 72678.0 72085.0 72587.0 True False 79309.89452656629 75966.34162991804 85775.7946471043 81305.87642359339 84506.2141959174 87865.45599401604 86481.87724607193 72889.48094750938 86504.0142231846 70491.22470632454 1.1251030870435499 1.0776709008306145 1.2168293997509225 1.1534184114735426 1.198818924596375 1.246473676121741 1.2268460025537433 1.034022053825512 1.227160041318212 1.0 16.105156050385034 -13.33358380774872 7.88817429512024 1.0269034655745086 1.1575863017556876 0.0 0.08385035377353801 0.0 0.0 0.0 0.018540731886999007 4.638912621723207e-14 13.33358380774872 0.13068283618117893 SCS(ph)PELQQK ddPTM_A459_Selumetinib_30min_R2 1 SCSPELQQK 9 0 P16152 P16152 CBR1 Carbonyl reductase [NADPH] 1 1 S(0.106)CS(0.894)PELQQK 127.51 0.0045456 8562100.0 68699.0 44348.0 61895.0 68094.0 67175.0 48371.0 51590.0 51725.0 48326.0 53634.0 True False 64880.984603886456 47749.348998704714 57912.74308618063 58819.47973129803 58735.87594788049 55033.66618178063 53989.037223645624 51875.51118646527 57992.55034125853 52085.44706213255 1.2456643508596585 0.9167502957542955 1.1118795431878834 1.1292881802690966 1.127683052769321 1.0566035099234372 1.0365474478743033 0.9959693947636304 1.1134117803016919 1.0 15.668592712050616 -6.948974949916968 6.0044962202331815 1.037450560556602 1.0972214941397689 0.14018178465625153 0.08104369707462528 0.45505763896220186 36.53203222967163 0.028136647282125216 0.024602402636772554 1.1246698429938874e-07 6.948974949916968 0.059770933583166874 SCS(ph)PLAFSAFGDLTIK ddPTM_A459_Selumetinib_30min_R1 1 SCSPLAFSAFGDLTIK 16 0 E9PLZ8;Q96EY5;Q96EY5-2 E9PLZ8 MVB12A Multivesicular body subunit 12A 1 S(0.04)CS(0.959)PLAFS(0.001)AFGDLTIK 138.05 0.00040569 26286000.0 2353.8 3180.4 2498.4 2849.1 2801.9 2917.2 2435.2 2609.7 1530.3 2445.4 True False 2408.638960302484 2808.037289472154 2159.1310027288528 2351.5581692307305 2548.468639715624 2887.8556166056746 2251.5109034092334 2540.4822784997136 2596.807331310168 2759.2909102131284 0.8729195429837588 1.0176662703735215 0.7824948774836071 0.8522327821712338 0.9235954897987829 1.0465933859734333 0.8159744574504926 0.9207011370553481 0.9411140092907384 1.0 11.430081851754498 -6.504477576082555 23.931901940475925 0.9377785065005617 0.8844956013704285 0.12666148153835244 0.07756587531011448 1130.3883958620147 1470144.8195358987 0.024757439518619598 0.027537661683120662 3.129842070458598e-07 6.504477576082555 -0.05328290513013323 SCSS(ph)PAVSAVSQLPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SCSSPAVSAVSQLPLSPK 18 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 2 S(0.005)CS(0.157)S(0.838)PAVSAVSQLPLS(1)PK 122.3 0.016609 12996000.0 1481.3 2014.2 2334.7 2634.9 1523.2 2022.2 1882.0 1589.6 1155.7 1884.3 True False 1515.81140789195 1778.3765276238237 2017.6605635891187 2174.7641781987463 1385.4268289428019 2001.8585040106943 1740.0392247931068 1547.4386442515026 1961.1384910116722 2126.1682596362953 0.7129310679067546 0.8364232320578592 0.9489656119380985 1.0228561019769733 0.6516073328927385 0.9415334345895722 0.8183920613558401 0.7278062953099531 0.9223816046182285 1.0 11.054040057324803 -8.521628499149534 24.42056345064823 1.0000000077199374 0.8391097184512453 0.195099251079775 0.10964704984229963 130.39876156218398 2546998.275205934 0.10584157064329497 0.02732817600856888 3.0086488374654447e-09 8.521628499149534 -0.1608902892686921 SCSSPAVSAVSQLPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SCSSPAVSAVSQLPLSPK 18 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 SCSSPAVSAVS(0.001)QLPLS(0.999)PK 159.44 1.5571e-05 17395000.0 2491.2 2413.2 3513.0 3469.8 2336.9 2673.3 2217.0 2577.2 1549.1 2504.5 True False 2549.240112968624 2130.6614221337572 3035.953895527723 2863.8645662127637 2125.5278076132063 2646.409029162193 2049.7699050830597 2508.8442840745906 2628.7095582124944 2825.976970895875 0.9020739161085515 0.7539556918110012 1.0743024188782693 1.0134069016510343 0.7521391113599144 0.9364581015404535 0.7253314256249064 0.8877794511111147 0.9301949680712209 1.0 11.46453399374877 -4.383701762648292 21.30758796216789 0.8901809454380346 11.889069111447162 0.0 0.11387812530846518 14246.254626358455 2168198.985574182 0.027609995665517268 45319.53512001374 4.1333124609689224e-05 4.383701762648292 10.998888166009127 SCSSPAVSAVSQLPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SCSSPAVSAVSQLPLSPK 18 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 SCSSPAVSAVSQLPLS(1)PK;SCSSPAVSAVSQLPLS(1)PK 211.13 1.0023e-11 14294000.0 121019.0 99484.0 107627.0 105764.0 96354.0 73060.0 94339.0 99846.0 67439.0 90977.0 True False 114293.24845744114 107114.10290852193 100702.39599541736 91358.7607469237 84249.14910431068 83123.35182735299 98725.95042918212 100136.53532960497 80928.6844030984 88350.25762336649 1.2936379760732397 1.2123801988800638 1.139808741981348 1.0340520017087254 0.953581250022624 0.9408388165850565 1.1174381726202405 1.1334039993010876 0.9159982843297872 1.0 16.430946721133488 -5.404541795344395 1.6798756215249206 1.0166644823887712 1.2801610258962175 0.6754418203755426 0.06774528097243543 0.2737350705288705 1.4090593803147762 0.02166224665979038 0.0773873968012671 3.939655116286134e-06 5.404541795344395 0.26349654350744633 SCT(ph)PSPDQISHR ddPTM_A459_Selumetinib_30min_R1 4 SCTPSPDQISHR 12 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 S(0.017)CT(0.887)PS(0.096)PDQISHR;S(0.143)CT(0.818)PS(0.039)PDQISHR;S(0.001)CT(0.708)PS(0.292)PDQISHR;SCT(0.713)PS(0.286)PDQIS(0.001)HR 162.67 0.0005767999999999999 80958000.0 8435.5 9839.7 9393.199999999999 10156.400000000001 9254.1 7808.1 8883.9 7168.2 4707.51 7752.300000000001 True False 8632.030737374289 8687.663349647575 8117.655033154283 8382.77539924011 8417.06828894405 7729.557603187571 8213.780270531079 6978.076050404893 7988.300647073081 8747.38321879661 0.9868129155271889 0.99317283035906 0.9280095349785121 0.9583180694801364 0.9622384293004598 0.8836422744779365 0.9389985627794479 0.7977329763500263 0.9132217541250058 1.0 13.094635783677068 -6.753414749797667 23.950081816419946 0.8960948891717754 0.9647309028396247 0.24210498485449483 0.05045078354971694 132.25437804478761 394721.29065322835 0.016323942204351773 0.0160290058018573 1.7643520654662656e-07 6.753414749797667 0.06863601366784933 SCT(ph)PSPDQISHR ddPTM_A459_Selumetinib_30min_R2 1 SCTPSPDQISHR 12 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 S(0.185)CT(0.752)PS(0.063)PDQISHR 160.79 0.00064539 57785000.0 34549.0 30444.0 31803.0 36392.0 37477.0 39103.0 34359.0 37131.0 26255.0 33923.0 True False 32628.904890605027 32778.95690711114 29756.829604488266 31435.346820298404 32768.80421136905 44489.083308308036 35956.761581066865 37239.04506263202 31506.73362599309 32943.554847461 0.9904488159121595 0.9950036375518065 0.9032671107374942 0.9542184189245493 0.9946954529679297 1.3504639530951186 1.091465743377057 1.1303893958942954 0.9563853619282788 1.0 15.007708620226612 -6.545641001719661 24.999576020667483 1.1196182340451937 0.9609998090157984 0.32182392847870256 0.10027680448839701 256.96727997723525 282222.7761026637 0.03298811775072452 0.03298995405492559 2.84681337960723e-07 6.545641001719661 -0.15861842502939527 SCTPS(ph)PDQISHR ddPTM_A459_Selumetinib_30min_R1 5 SCTPSPDQISHR 12 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 SCT(0.447)PS(0.551)PDQIS(0.002)HR;SCT(0.486)PS(0.514)PDQISHR;SCT(0.002)PS(0.998)PDQISHR;SCT(0.063)PS(0.937)PDQISHR;S(0.01)CT(0.008)PS(0.983)PDQISHR 233.52 2.552e-10 90111000.0 14325.7 17329.8 16019.6 17898.8 17947.1 14646.5 16504.0 14553.399999999998 7363.040000000001 14169.300000000001 True False 14659.460937040234 15300.818959594548 13844.226309364049 14773.110582088033 16323.78797381786 14499.169507957986 15259.089992553367 14167.396555894442 12494.541104835673 15988.067675669763 0.9169001054047721 0.9570148982343217 0.8659099142063204 0.924008509456673 1.0209981784514828 0.9068744142247068 0.9544048913286916 0.8861231290291589 0.7814916322783365 1.0 13.964707964197187 -7.870453416014176 6.037101348163318 0.8728535659269385 0.9349609542708776 0.08846377634786728 0.06230866176134715 0.38374940394355445 18.821041562942696 0.03339241901593535 0.015803895009687204 1.347555261209381e-08 7.870453416014176 0.06210738834393903 SCTPS(ph)PDQISHR ddPTM_A459_Selumetinib_30min_R2 5 SCTPSPDQISHR 12 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 SCT(0.315)PS(0.685)PDQISHR;S(0.007)CT(0.003)PS(0.99)PDQISHR;SCT(0.119)PS(0.881)PDQISHR;SCT(0.002)PS(0.998)PDQISHR;S(0.007)CT(0.061)PS(0.93)PDQIS(0.001)HR 168.89 0.00037019 158192900.0 309521.0 294669.0 318605.0 337674.0 391096.0 278710.0 262254.0 290101.0 265012.0 339407.0 True False 292319.06193073513 317269.1647898278 298106.3011708956 291682.21867985924 341963.02403739886 317099.77262252354 274449.3306464427 290945.14588119445 318021.80505395884 329607.43802470824 0.886870343953895 0.9625667633327025 0.9044283192072526 0.8849382174985808 1.0374857621136706 0.9620528423838327 0.8326551496870931 0.8827020034037716 0.9648502077496173 1.0 18.330389273633557 -5.718177986649035 0.005296797582026969 1.844724964459647 2.0862737355327805e-05 0.07327775607553733 0.05774304634849179 75292.23440625168 87.5872657540788 14840.361018169104 15667.758179803901 1.913471567392049e-06 5.718177986649035 -1.8447041017222918 SCTPSPDQIS(ph)HRAS(ph)LEDAPVDDLTR ddPTM_A459_Selumetinib_30min_R2 1 SCTPSPDQISHRASLEDAPVDDLTR 25 1 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 2 S(0.085)CT(0.32)PS(0.335)PDQIS(0.65)HRAS(0.61)LEDAPVDDLTR 62.295 0.024042 0.0 3650.4 4863.2 4441.1 5336.1 7028.5 3858.9 3037.8 3840.2 3609.6 5286.2 True False 3447.5253817090097 5236.191802347357 4155.364461104072 4609.313974714064 6145.516994412772 4390.428447393545 3179.0637192865033 3851.374346220665 4331.620860650723 5133.573670802949 0.6715644116138257 1.019989609212788 0.8094486857639905 0.8978762691045817 1.197122587207664 0.8552382275848068 0.619269133579856 0.7502326046522415 0.8437827405276545 1.0 12.325747773688525 -7.001380732356306 24.99924529400236 0.7760423710242412 0.9283839892439986 0.09910480057176607 0.15544594422420868 94.36759904651385 1708634.4759797142 0.054696826840410245 0.047584546502412846 9.968257947345837e-08 7.001380732356306 0.15234161821975734 SCTPSPDQISHRAS(ph)LEDAPVDDLTR ddPTM_A459_Selumetinib_30min_R1 4 SCTPSPDQISHRASLEDAPVDDLTR 25 1 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 SCTPSPDQIS(0.12)HRAS(0.88)LEDAPVDDLTR;SCTPSPDQIS(0.186)HRAS(0.814)LEDAPVDDLTR;SCTPSPDQIS(0.023)HRAS(0.977)LEDAPVDDLTR;SCTPSPDQIS(0.016)HRAS(0.984)LEDAPVDDLTR 112.57 7.354e-08 63950000.0 3335.1000000000004 3738.3999999999996 5855.299999999999 5962.629999999999 4846.23 3990.09 3783.2799999999997 3074.73 1709.7999999999997 1936.83 True False 3412.801341025072 3300.706390064991 5060.182420860649 4921.368602927323 4407.889352171399 3949.9533173118552 3497.904143663799 2993.1781722693886 2901.4057211488753 2185.440996821824 1.5616076325044401 1.5103159476119654 2.3154056450022744 2.251888113238573 2.016933588498417 1.8073941703555816 1.6005484242084889 1.3695991685990223 1.3276065221473574 1.0 11.093708713006837 -7.761530392302461 1.1127262111516574 1.1016100139161662 1.9445828431182894 0.6140916565588828 0.24789926979979743 0.38459003925966084 0.8614629345208407 0.2411790841455248 0.09549606921242107 1.7316878415008166e-08 7.761530392302461 0.8429728292021232 SCTPSPDQISHRAS(ph)LEDAPVDDLTR ddPTM_A459_Selumetinib_30min_R2 2 SCTPSPDQISHRASLEDAPVDDLTR 25 1 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 SCTPSPDQIS(0.004)HRAS(0.996)LEDAPVDDLTR;SCTPSPDQIS(0.384)HRAS(0.616)LEDAPVDDLTR 141.5 9.4238e-09 36377000.0 38037.0 46426.0 47329.0 45051.0 41985.0 29884.9 17927.0 16101.0 17972.0 44642.0 True False 35923.055814175335 49986.72491688159 44283.90366791891 38914.97608269023 36710.46894933773 34001.27370688831 18760.641021676583 16147.851244335956 21566.90217963618 43353.06946615433 0.8286162031092263 1.1530146661450613 1.0214710103166116 0.8976290851348158 0.8467790032260006 0.7842875746879479 0.43274077828152363 0.3724730784504787 0.49747116975127736 1.0 15.403846521712358 -6.847163158239903 1.7265729500253806 0.527403364548603 0.9858308800636688 0.4702427705219596 0.1831069985388784 0.2692937529870622 1.65425494554073 0.07815366687325388 0.06677026337433972 1.4217945388537166e-07 6.847163158239903 0.4584275155150658 SCTVNIMFGT(ph)PQEHR ddPTM_A459_Selumetinib_30min_R2 1 SCTVNIMFGTPQEHR 15 0 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 SCT(0.002)VNIMFGT(0.997)PQEHR 92.8 0.017800999999999997 3382700.0 23284.0 18901.0 26180.0 25340.0 26461.0 19393.0 20551.0 20191.0 16782.0 22265.0 True False 21989.968493237073 20350.64592370609 24495.60730262877 21888.648286061798 23136.73261565859 22064.20971787374 21506.66222103396 20249.75246720001 20138.868928258093 21622.151598582655 1.017011114410951 0.9411943039489229 1.1328940688878748 1.0123251696883215 1.0700476550712565 1.0204446868886101 0.9946587472101405 0.9365280959609679 0.9313998579853731 1.0 14.400222470899399 -7.472618087218528 2.654425086274558 0.9509680291898123 1.0337857188495552 0.32839052936895985 0.0487105394296969 0.3193975174679975 4.451617004680122 0.025173546746203014 0.014427199738913769 3.36807623320273e-08 7.472618087218528 0.0828176896597429 SCVEEPEPEPEAAEGDGDKKGNAEGS(ph)SDEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R1 1 SCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAK 40 3 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 SCVEEPEPEPEAAEGDGDKKGNAEGS(0.5)S(0.5)DEEGKLVIDEPAK 67.441 1.3345e-07 23111000.0 871.29 1080.9 1222.8 1608.0 734.03 822.84 942.52 838.29 652.59 744.82 True False 891.589361764785 954.3477255032225 1056.750476359607 1327.1929858983585 667.6371161035223 814.5629766789432 871.4249575727945 816.0558260503219 1107.397566712215 840.4249021611771 1.0608792760329175 1.1355538407406653 1.2574002431890612 1.5791928374390658 0.7944042524045564 0.969227559278968 1.036886169521988 0.9710038623936661 1.3176639148417781 1.0 9.714975100110502 -6.279245398784688 24.999997080239314 1.0122337641350752 1.2494309553077352 0.3192810748484788 0.1738879982287218 1075.3073322444332 1509748.7343656619 0.05567381225828308 0.06326204368052454 5.257201234598515e-07 6.279245398784688 0.23719719117266003 SCVEEPEPEPEAAEGDGDKKGNAEGS(ph)SDEEGKLVIDEPAK ddPTM_A459_Selumetinib_30min_R2 1 SCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAK 40 3 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 S(0.001)CVEEPEPEPEAAEGDGDKKGNAEGS(0.5)S(0.5)DEEGKLVIDEPAK 45.021 0.004869699999999999 11466000.0 43063.0 53342.0 40571.0 31464.0 23524.0 18643.0 15219.0 16212.0 8039.4 35634.0 True False 40669.730854847476 57433.15987843659 37960.70603036485 27178.548921572572 20568.704812771724 21210.904025695894 15926.713655876394 16259.174235958926 9647.504639604227 34605.153831749114 1.1752506881658278 1.65967069985233 1.0969668337534486 0.7853902067222464 0.5943827012813507 0.6129406078881687 0.4602410881717898 0.4698483444116829 0.2787880870725375 1.0 15.078699297578838 -5.752123093466431 1.8147891613689926 0.5377853955796704 1.4269612734212331 0.7230867880356515 0.20915959543283597 0.16373703469117096 1.0979126137028519 0.06214491108371577 0.12945870377041868 1.7696073217984907e-06 5.752123093466431 0.8891758778415627 SCYDLSCHAR ddPTM_A459_Selumetinib_30min_R2 1 SCYDLSCHAR 10 0 P41250 P41250 GARS Glycine--tRNA ligase 0 153.1 0.0019604 0.0 14021.0 13234.0 16054.0 22323.0 25068.0 16225.0 15057.0 14762.0 15892.0 24545.0 False True 13241.768950510086 14249.00524598309 15021.103118273582 19282.568890677103 21918.733729236585 18459.84647411444 15757.180334879486 14804.954976019348 19070.84405958035 23836.322074431213 0.5555290329255238 0.5977853966517652 0.6301770496039087 0.808957389922213 0.9195518360925493 0.774441896550642 0.6610575358763895 0.6211090339268553 0.8000749444494751 1.0 14.540874025822543 -14.5228787311344 0.038880277587516485 2.170391361924442 2.7314038713953303e-19 0.4627859470564657 0.10260596928975547 1044.4599190662532 3.0250230905142677 149.83911493622333 46.42019396088084 3.000000097716679e-15 14.5228787311344 -2.170391361924442 SDADSGFLGLRPT(ph)SVDPALRR ddPTM_A459_Selumetinib_30min_R1 1 SDADSGFLGLRPTSVDPALRR 21 2 Q9NZM5 Q9NZM5 GLTSCR2 Glioma tumor suppressor candidate region gene 2 protein 1 SDADSGFLGLRPT(0.5)S(0.5)VDPALRR 66.20100000000001 0.012262 7360900.0 3111.8 2888.9 3362.4 3808.4 3076.7 2881.9 2919.5 2931.6 1524.3 2042.7 True False 3184.2988854912373 2550.6662449868263 2905.8045483411356 3143.33443252196 2798.4130282355036 2852.9107025558387 2699.2797644970647 2853.844444821154 2586.625769532828 2304.9004425829544 1.3815342418533259 1.1066275132163443 1.2607071848555795 1.363761477263385 1.214114491253037 1.23775875514986 1.1711047100464584 1.238163866905693 1.122228848476493 1.0 11.170488721176225 -8.733492049196895 0.5557307075121114 0.9921045937616744 1.263132494842255 0.5362679956608021 0.07497553273990716 0.975575289770726 0.6550293740026191 0.08738492266942485 0.03548156879100934 1.8471746115658434e-09 8.733492049196895 0.2710279010805807 SDADSGFLGLRPT(ph)SVDPALRR ddPTM_A459_Selumetinib_30min_R2 2 SDADSGFLGLRPTSVDPALRR 21 2 Q9NZM5 Q9NZM5 GLTSCR2 Glioma tumor suppressor candidate region gene 2 protein 1 SDADSGFLGLRPT(0.5)S(0.5)VDPALRR;SDADSGFLGLRPT(0.827)S(0.173)VDPALRR 73.953 0.0044363 5907400.0 20456.1 25833.0 24190.0 24951.0 27581.0 18095.2 18014.3 18255.1 16694.199999999997 26456.0 True False 19319.231854256446 27814.308033812977 22633.64173608061 21552.630757124247 24116.02820273154 20587.649548129186 18852.00064465826 18308.2193187055 20033.506474921123 25692.146539056946 0.7519508665765837 1.082599618195776 0.8809556531865943 0.8388801116465746 0.9386536919393089 0.8013207272047917 0.7337651066250784 0.7125998324380381 0.779752148948177 1.0 14.649039809760248 -6.850544826224683 5.7694821825909415 0.78093758100284 0.9042696902755177 0.13929664013915533 0.10771766224936027 0.3107121178135839 15.977414338289526 0.03668617615681984 0.03245501930025302 1.4107666149785068e-07 6.850544826224683 0.12333210927267768 SDAEEDGGTVS(ph)QEEEDR ddPTM_A459_Selumetinib_30min_R1 2 SDAEEDGGTVSQEEEDR 17 0 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 SDAEEDGGT(0.006)VS(0.994)QEEEDR;SDAEEDGGT(0.001)VS(0.999)QEEEDR 223.86 2.3687e-12 4423800.0 1103.11 1655.51 764.6700000000001 689.3499999999999 1194.23 1122.43 1422.4 1472.08 519.0600000000001 1551.6999999999998 True False 1128.810316721588 1461.6821195742818 660.8320140316491 568.9679632021356 1086.2121073584308 1111.1393732848987 1315.10722281919 1433.0356564102615 880.806909357548 1750.875809837944 0.6447118124420643 0.8348291245794132 0.3774294043692418 0.3249619190608371 0.6203821546080801 0.6346191814642426 0.7511139370535438 0.8184679052381786 0.5030664678833349 1.0 10.77386104125765 -7.003091341540896 2.2508923235498575 0.7532466278776316 0.5514969284771741 0.24054222950515458 0.17384300539725636 0.5267316921412684 5.352461697639339 0.07799979533361641 0.06130010654179602 9.929071965584962e-08 7.003091341540896 -0.2017496994004575 SDAEEDGGTVS(ph)QEEEDR ddPTM_A459_Selumetinib_30min_R2 2 SDAEEDGGTVSQEEEDR 17 0 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 SDAEEDGGTVS(1)QEEEDR;SDAEEDGGT(0.001)VS(0.999)QEEEDR 268.82 1.6219e-51 14344300.0 43146.0 9710.099999999999 31740.0 33821.0 15239.7 21089.0 88562.0 50742.0 66036.0 19107.1 True False 40748.11804712276 10454.83344710748 29697.88295589905 29214.52145552079 13325.15264135339 23993.818323118612 92680.30848227376 50889.65081920966 79245.04520000296 18555.428376792217 2.1960214132316964 0.5634379996413139 1.6004956799080428 1.5744460791894297 0.7181269206384653 1.2930888921501988 4.994781397673985 2.7425748296309203 4.270720329966454 1.0 14.179553687507003 -7.224205988565024 23.242070075408318 3.3972333948605624 1.2860605160242327 0.4375474227581788 1.065142771194919 197.42256611134675 123236.28360637308 0.37511510275699633 0.2905493224736014 5.967521761921124e-08 7.224205988565024 -2.1111728788363298 SDAEEDGGTVS(ph)QEEEDRKPK ddPTM_A459_Selumetinib_30min_R1 1 SDAEEDGGTVSQEEEDRKPK 20 2 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 SDAEEDGGT(0.001)VS(0.999)QEEEDRKPK 115.31 0.00030686 26733000.0 2291.9 2874.5 2322.8 1917.7 2602.9 2924.3 2622.2 2937.2 1367.2 2778.2 True False 2345.2968107389165 2537.9522036812054 2007.3765182270974 1582.8096946873648 2367.468154579321 2894.884197051958 2424.405342854667 2859.2959146297903 2320.038543662851 3134.8090319596404 0.7481466292933379 0.8096034488246557 0.6403504959191216 0.5049142319517672 0.7552192591136446 0.9234642900216158 0.7733821480471862 0.9121116742611844 0.7400892749797082 1.0 11.614161843467258 -6.531872070143476 12.098258694696888 0.8562289029382705 0.6761990305000738 0.4494499541142323 0.101124936506553 0.4437238924116358 585.1389529763476 0.03380643940771805 0.03427309394408284 2.938515121063965e-07 6.531872070143476 -0.18002987243819668 SDAEEDGGTVS(ph)QEEEDRKPK ddPTM_A459_Selumetinib_30min_R2 4 SDAEEDGGTVSQEEEDRKPK 20 2 P27824-3;P27824;P27824-2 P27824-3 CANX Calnexin 1 SDAEEDGGT(0.219)VS(0.781)QEEEDRKPK;SDAEEDGGT(0.04)VS(0.96)QEEEDRKPK;SDAEEDGGT(0.008)VS(0.992)QEEEDRKPK;SDAEEDGGT(0.005)VS(0.995)QEEEDRKPK 99.414 0.00092681 105092000.0 195138.0 56128.3 128282.0 133241.0 61215.0 71550.0 250293.0 153149.0 121706.0 98630.0 True False 184293.01115930662 60433.16012907001 120028.47578288111 115093.34594645485 53524.6244309565 81405.3630337683 261932.1204461705 153594.6382348182 146050.60074976637 95782.29562848462 1.9240822111231575 0.6309429078989192 1.2531384322677055 1.201613985040335 0.5588154270029717 0.8498998953785696 2.734661126333192 1.6035806745598695 1.5248183371618054 1.0 16.547471392823738 SDAGLES(ph)DTAMK ddPTM_A459_Selumetinib_30min_R1 3 SDAGLESDTAMK 12 0 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 SDAGLES(0.659)DT(0.341)AMK;SDAGLES(0.921)DT(0.079)AMK;SDAGLES(0.937)DT(0.063)AMK 170.0 0.00032435 102318000.0 6629.700000000001 10943.8 9227.900000000001 11291.9 8293.7 9319.4 8442.7 7350.9 4301.23 6326.3 True False 6784.159110849431 9662.494808365405 7974.801865226375 9319.981640214975 7543.536299371667 9225.655297338175 7805.860341743232 7155.930252911655 7298.873160590237 7138.342228380348 0.9503830012348288 1.353604870602817 1.117178416232338 1.3056226981050234 1.0567630491825348 1.2924086576655245 1.0935116434609973 1.002463880823951 1.0224885452495758 1.0 12.801373353792325 -7.529575821754334 4.897978379114901 1.0135574345706257 1.1856332553166335 0.3091061748404913 0.11455806351456561 0.20966267434336075 14.23111544184765 0.04955437582237273 0.029445075730901906 2.9540931000360847e-08 7.529575821754334 0.1720758207460078 SDAGLES(ph)DTAMK ddPTM_A459_Selumetinib_30min_R2 4 SDAGLESDTAMK 12 0 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 SDAGLES(0.999)DT(0.001)AMK;SDAGLES(0.68)DT(0.32)AMK;SDAGLES(0.993)DT(0.007)AMK;SDAGLES(0.773)DT(0.227)AMK 201.09 8.465700000000001e-05 201033000.0 355416.0 305942.0 311815.0 310890.0 331086.0 275147.0 292894.0 302580.0 222977.0 298312.0 True False 335663.4015629768 329406.76764142 291753.16237850196 268546.2456848362 289492.016733606 313046.0017142166 306514.15135845065 303460.4577051843 267578.63049792644 289698.9574523416 1.1586627874496125 1.1370657683350853 1.0070908260914204 0.9269838181209703 0.9992856697844014 1.080590708600378 1.0580436811163716 1.0475027607067124 0.9236437467744281 1.0 18.144194967187886 -5.238590446247604 5.285886354466391 1.0083956467198696 1.1508405691078392 0.5823922386576089 0.04827722110970068 0.13638691199417943 11.855141594719687 0.013537249300757986 0.035158704714131156 5.773106293770439e-06 5.238590446247604 0.14244492238796957 SDAGLES(ph)DTAMKK ddPTM_A459_Selumetinib_30min_R2 2 SDAGLESDTAMKK 13 1 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 SDAGLES(0.973)DT(0.027)AMKK;SDAGLES(0.996)DT(0.004)AMKK 138.28 0.0017889 10091700.0 32700.0 27877.0 29584.0 32144.0 22299.7 23632.0 22753.0 21535.5 17810.4 26879.0 True False 30882.66490847156 30015.076261317077 27680.597648623745 27765.93174850712 19498.2123241526 26887.09349006304 23811.05958421417 21598.164739606047 21372.977664154936 26102.93342997094 1.1831108940810695 1.1498736853404483 1.0604401119470104 1.0637092502648284 0.74697398958866 1.0300410703722571 0.9121986097116088 0.827422894731341 0.8187960070271202 1.0 14.671924324546364 -6.070551374447354 5.507489375511149 0.8886729046419035 1.1230950757830918 0.639614915954978 0.08375544463165539 0.14192598715737667 8.00341226851295 0.025098748105942606 0.033108504415124605 8.500581304319409e-07 6.070551374447354 0.23442217114118824 SDAGLESDT(ph)AMK ddPTM_A459_Selumetinib_30min_R1 1 SDAGLESDTAMK 12 0 Q9NR30 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 SDAGLES(0.205)DT(0.795)AMK 126.5 0.0063754 88590000.0 4850.5 7448.6 7024.5 8216.0 5082.3 6928.5 6741.8 5469.5 2781.3 4370.5 True False 4963.507212569971 6576.514449239803 6070.611482816531 6781.229833420967 4622.606862352941 6858.805580574668 6233.260598145682 5324.431092560134 4719.662961885233 4931.496247275075 1.006491126362021 1.3335738525348553 1.2309877526867998 1.3750856724605585 0.9373639622877514 1.3908163438965484 1.2639694497567353 1.0796786260360995 0.9570448247817502 1.0 12.267809720518777 -7.949730734755601 3.8345467143645147 0.9858159250381565 1.2256866747012356 0.33015915709881816 0.13981319627098987 0.24790775100405074 7.482071679059669 0.0861415857784444 0.03611469475472004 1.1227143283311649e-08 7.949730734755601 0.23987074966307909 SDAPDSTGDQPGLHQDNS(ph)SNGK ddPTM_A459_Selumetinib_30min_R2 1 SDAPDSTGDQPGLHQDNSSNGK 22 0 O15164-2;O15164 O15164-2 TRIM24 Transcription intermediary factor 1-alpha 1 SDAPDSTGDQPGLHQDNS(0.5)S(0.5)NGK 103.74 0.00017699 0.0 8923.7 8915.9 11027.0 9785.7 9186.5 7237.3 9249.7 6948.9 7143.6 8466.3 True False 8427.756478401465 9599.72086086297 10317.534825289817 8452.870778725934 8032.409741647995 8234.172381331804 9679.829377932843 6969.120148547676 8572.519608860948 8221.85592091086 1.025043075367805 1.1675856343392919 1.2548912221933932 1.028097653381097 0.976958221953143 1.001498014625824 1.1773289961593563 0.8476334559479364 1.0426501864449162 1.0 13.005248375122845 -5.908988552818605 8.69272348601713 1.0077351667446597 1.1506386071208359 0.3272400566965389 0.09143470751829536 0.310188102932113 26.523636005082178 0.025667362628979215 0.03816034384357776 1.2331373359691574e-06 5.908988552818605 0.1429034403761762 SDASDMNSDTS(ph)PSCR ddPTM_A459_Selumetinib_30min_R1 1 SDASDMNSDTSPSCR 15 0 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 SDASDMNSDT(0.033)S(0.967)PSCR 175.27 1.9918e-05 5787800.0 2840.2 3812.8 3343.8 3027.4 3108.6 2770.2 2794.8 2906.7 1654.4 2536.7 True False 2906.3711339328393 3366.3956034773696 2889.730326178651 2498.7214213362518 2827.4276788679067 2742.3343031403538 2583.9859858936125 2829.604873707751 2807.3959674047846 2862.3101545504383 1.0153935028013488 1.1761114001309563 1.0095797346016542 0.8729736773507367 0.9878131740450712 0.9580842588915987 0.9027624004287753 0.9885738165758545 0.9808147320938116 1.0 11.482964292920963 -5.515420660100825 24.595858459918745 0.9535712720171783 1.095025753171929 0.5305598369163791 0.052258565871664234 179.14792645285752 590806.911335215 0.01320520425432088 0.02418802197245891 3.0519635318775817e-06 5.515420660100825 0.14145448115475068 SDASDMNSDTS(ph)PSCR ddPTM_A459_Selumetinib_30min_R2 1 SDASDMNSDTSPSCR 15 0 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 SDAS(0.014)DMNS(0.227)DT(0.223)S(0.536)PSCR 115.83 0.0023287 4213600.0 17709.0 19005.0 22488.0 22520.0 24704.0 18723.0 20238.0 19932.0 19607.0 20809.0 True False 16724.804674743835 20462.622389293363 21041.146563083108 19452.737150833138 21600.46266343787 21301.923299528196 21179.107100836205 19989.998820079774 23528.94786535315 20208.19010172497 0.8276250663990046 1.0125905529534125 1.0412187562154336 0.9626164962280642 1.068896450137514 1.0541232635034379 1.0480457178116291 0.9892028291229025 1.1643273220863417 1.0 14.302652495517851 -4.75046254391649 3.4335507647830927 1.0392417663891926 0.7923258972687507 0.6020030866477895 0.051726904095663204 0.22991822982579507 4.154502372721611 0.012504237217168057 0.1562230720692306 1.7763864675886453e-05 4.75046254391649 -0.24691586912044194 SDASS(ph)DQGPASPEK ddPTM_A459_Selumetinib_30min_R1 1 SDASSDQGPASPEK 14 0 H7C1J4;Q6BDS2 H7C1J4 UHRF1BP1 UHRF1-binding protein 1 1 SDAS(0.033)S(0.967)DQGPASPEK 188.39 9.2537e-05 3516200.0 1647.6 1991.4 1855.9 2071.6 1842.8 1790.7 2004.7 2034.7 887.49 1355.2 True False 1685.9858743284788 1758.245962223256 1603.8789737289785 1709.8339487481585 1676.1190653727645 1772.687183825512 1853.4838650067702 1980.7331463629412 1506.0057102950143 1529.1531207658586 1.1025618372894352 1.1498168092824208 1.0488674756951053 1.1181574464510187 1.0961093710048473 1.1592607435792186 1.2120982783453853 1.2953138043958043 0.9848625947548986 1.0 10.578517161935705 -6.76284204905884 24.94139369382161 1.153876152533679 1.1035211380217635 0.0 0.09003735982277598 110.83860214566923 1970838.566512823 0.030011692012547803 0.027901527716812365 1.7264656855910452e-07 6.76284204905884 -0.050355014511915375 SDASS(ph)DQGPASPEK ddPTM_A459_Selumetinib_30min_R2 1 SDASSDQGPASPEK 14 0 H7C1J4;Q6BDS2 H7C1J4 UHRF1BP1 UHRF1-binding protein 1 1 SDAS(0.026)S(0.974)DQGPASPEK 188.19 9.1612e-05 3282900.0 28118.0 27942.0 27358.0 27692.0 32122.0 24892.0 25549.0 25713.0 18790.0 23729.0 True False 26555.3141252723 30085.06155230917 25597.816065138184 23920.30182863551 28086.547185676467 28320.64705292186 26737.07912438306 25787.82057298371 22548.525036465835 23043.882114653832 1.1523802279992361 1.3055552620266957 1.1108291536025643 1.03803264179278 1.2188288000230636 1.2289876728241238 1.160268004815937 1.1190744877394152 0.978503748816134 1.0 14.49209616211821 -8.116729517700362 2.715214363750092 0.9862130684854477 1.1745396255180125 0.5331997134934625 0.0678793873232277 0.23749491905076484 3.1528533596562722 0.06072652107607202 0.019361026675407986 7.643116551778183e-09 8.116729517700362 0.18832655703256485 SDATNYASHS(ph)PPVNR ddPTM_A459_Selumetinib_30min_R1 1 SDATNYASHSPPVNR 15 0 Q96FJ0;Q96FJ0-2 Q96FJ0 STAMBPL1 AMSH-like protease 1 SDATNYASHS(1)PPVNR 137.32 0.00040211 7959800.0 2798.2 2927.1 2587.2 2395.7 1768.8 3056.2 2612.9 2174.3 1550.6 1870.8 True False 2863.392615650614 2584.393771228127 2235.8724504723386 1977.335967858642 1608.812352307003 3025.4574028075754 2415.8068493421424 2116.630500878235 2631.2549486568305 2110.9354031351577 1.356456768595528 1.2242884208535183 1.0591856326591635 0.9367107894073433 0.7621324413421641 1.433230689254712 1.1444248107991322 1.002697902424972 1.2464876683336188 1.0 11.043666716022447 -5.017623378476585 2.854330548708822 1.0730722406298938 1.3535872011926684 0.22293485252123368 0.1706817457397239 0.4626979192570499 6.983985973310252 0.04669430934122383 0.23385121110906792 9.602329875817374e-06 5.017623378476585 0.2805149605627746 SDATNYASHS(ph)PPVNR ddPTM_A459_Selumetinib_30min_R2 1 SDATNYASHSPPVNR 15 0 Q96FJ0;Q96FJ0-2 Q96FJ0 STAMBPL1 AMSH-like protease 1 SDAT(0.002)NY(0.013)AS(0.046)HS(0.939)PPVNR 77.357 0.023174 35895000.0 23102.0 14827.0 19139.0 20410.0 21697.0 20499.0 17412.0 20124.0 15607.0 20176.0 True False 21818.08332463335 15964.183223680751 17907.617576967623 17630.122790786176 18971.228886358964 23322.551178605365 18221.69250122345 20182.55750829246 18728.836096015024 19593.46645645648 1.1135387080749974 0.8147707430514523 0.9139586206843285 0.8997960024055193 0.9682425990581939 1.190322867596513 0.9299881948770223 1.0300656881284964 0.9558714961253555 1.0 14.258085039897352 -6.527972993922087 24.999975326577896 1.0242979962487735 0.9264349949702994 0.1520504303047947 0.09492441298517053 234.73611464279858 1151953.557332313 0.030292273920912174 0.030392789668202632 2.965015759716397e-07 6.527972993922087 -0.09786300127847414 SDDS(ph)DEDEPCAISGK ddPTM_A459_Selumetinib_30min_R2 2 SDDSDEDEPCAISGK 15 0 Q96QB1-6;Q96QB1-4;Q96QB1-1;Q96QB1 Q96QB1-6 DLC1 Rho GTPase-activating protein 7 1 S(0.017)DDS(0.983)DEDEPCAISGK;SDDS(1)DEDEPCAISGK 180.74 2.0266e-05 11995000.0 59112.0 50342.0 55906.0 68491.0 66992.0 58817.0 55673.0 51070.0 43134.0 48848.0 True False 55826.791684084776 54203.06952495698 52309.06882585043 59162.40764643489 58575.8660439212 66918.50786243382 58261.90481395662 51218.60524490639 51762.005264657615 47437.63131765393 1.1768461057900421 1.142617538426403 1.1026914155046268 1.2471619261566624 1.2347974470243452 1.41066292737787 1.2281790467955855 1.079704104573311 1.0911591457433154 1.0 15.533744353775912 -7.796534453246134 5.370165021137199 1.0604481132144485 1.2220203865675268 0.468912318912031 0.0798424950912302 0.19776971723978326 14.2306554598813 0.04942968762100165 0.023977008597301584 1.597590784708506e-08 7.796534453246134 0.16157227335307822 SDDT(ph)LDEEDSFVMK ddPTM_A459_Selumetinib_30min_R1 2 SDDTLDEEDSFVMK 14 0 P53355-4;P53355;P53355-3 P53355-4 DAPK1 Death-associated protein kinase 1 1 S(0.001)DDT(0.999)LDEEDSFVMK;SDDT(1)LDEEDSFVMK 196.8 2.1008e-15 4353200.0 1876.8400000000001 1944.6499999999999 2201.06 2344.8 2212.15 1942.95 2123.2 1824.88 1166.57 1808.69 True False 1920.5667203050873 1716.9694739567424 1902.1681415571447 1935.3246973473083 2012.0614230868048 1923.4056870574507 1963.0453146018733 1776.4782543543542 1979.5840870982834 2040.8529796325267 0.9410607914789149 0.8412999324752426 0.9320456498045472 0.9482920703556903 0.9858923906655411 0.9424518602039509 0.9618749288620176 0.8704587111778256 0.9699787818398975 1.0 10.994956540920626 -5.500326835526439 17.288048021777406 0.9491488366743319 0.8900526062614306 0.27746862667954086 0.0396839353065851 19.067313643917796 14613.541012358748 0.010095816088175889 0.020495275007504418 3.159898730850162e-06 5.500326835526439 -0.05909623041290135 SDDYMPMS(ph)PASVSAPK ddPTM_A459_Selumetinib_30min_R1 1 SDDYMPMSPASVSAPK 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 SDDYMPMS(0.993)PAS(0.007)VSAPK 224.06 2.8906e-11 7637700.0 4331.1 4590.7 5003.1 5155.3 5012.4 4090.0 5162.3 5283.0 2643.8 4044.1 True False 4432.006203146443 4053.218709841472 4323.70650006113 4255.0236319663 4559.029305011093 4048.8583134228747 4772.903554808425 5142.877678397512 4486.335504487893 4563.199627869837 0.9712496854351654 0.8882404979800476 0.947516403545881 0.9324649322766101 0.9990860967744489 0.8872849411834599 1.0459554575823982 1.1270332437325947 0.9831556518122733 1.0 12.15583005390436 -7.281657083372672 23.174868637971365 1.0496222442890244 0.9384016253531651 0.5140900323038984 0.047848784951350996 236.36579998374958 270935.9662357066 0.019083702775142132 0.012891360552595309 5.228088331580689e-08 7.281657083372672 -0.11122061893585933 SDDYMPMS(ph)PASVSAPK ddPTM_A459_Selumetinib_30min_R2 2 SDDYMPMSPASVSAPK 16 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 SDDYMPMS(0.974)PAS(0.026)VSAPK;SDDY(0.325)MPMS(0.658)PAS(0.015)VS(0.001)APK 179.66 1.0536e-06 10057500.0 92288.0 73696.0 87286.0 93859.0 93795.0 73633.0 85314.0 96662.0 73985.0 107371.0 True False 87159.00241813531 79348.24623001146 81670.11378981116 81075.24228419404 82011.63356206112 83775.27737617688 89281.27004648393 96943.27041674442 88784.06731362008 104270.92024663916 0.8358898359386504 0.7609815473223369 0.7832491896746595 0.7775441330374875 0.7865245014436756 0.8034385538941966 0.8562432347897267 0.9297248953729175 0.8514748609066942 1.0 16.669977340199445 -8.12390535842973 0.5638526122198522 0.9927970541385793 0.7780579353245282 0.7878742430587419 0.03308502336316864 0.3334086538200449 0.2519099637687185 0.0330250988411276 0.017182933522322894 7.517867057296666e-09 8.12390535842973 -0.21473911881405117 SDEEDEDS(ph)DFGEEQR ddPTM_A459_Selumetinib_30min_R2 1 SDEEDEDSDFGEEQR 15 0 Q5VW52;Q9HCL2 Q5VW52 GPAM Glycerol-3-phosphate acyltransferase 1, mitochondrial 1 SDEEDEDS(1)DFGEEQR 177.66 1.9564e-05 2603100.0 4388.2 4047.7 4383.9 6616.5 4742.1 5858.8 5415.2 4741.0 5262.6 3960.1 True False 4144.321411356422 4358.14557459315 4101.8446468294205 5715.321285900867 4146.355003088112 6665.796519108889 5667.017530015235 4754.795525085198 6315.267049329699 3845.7616234245315 1.0776334617604384 1.1332334141689095 1.0665883766287247 1.4861350872838424 1.07816224953535 1.7332838516322817 1.4735748298847842 1.2363729192479695 1.642136894513537 1.0 11.909053625769069 -5.75415087243828 24.976038900167662 1.3945996442033415 1.0965598356148503 0.2638971080518985 0.21773291371149864 211.27493836961037 723982.1659437998 0.05683293214266671 0.09593050179761493 1.7613640481848895e-06 5.75415087243828 -0.2980398085884912 SDEGQLS(ph)PATR ddPTM_A459_Selumetinib_30min_R1 1 SDEGQLSPATR 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 SDEGQLS(1)PATR 169.58 0.00041306 154470000.0 5815.8 5866.3 5224.2 5158.2 5496.8 5314.2 5041.2 5074.6 2528.6 4535.5 True False 5951.296824423142 5179.470868831121 4514.7823344764965 4257.417201406041 4999.615410538861 5260.7439729075395 4660.938225306592 4940.005123376113 4290.849518362995 5117.675604511177 1.1628905941551155 1.0120748693538668 0.8821939261833563 0.8319044680466212 0.9769308953720617 1.0279557321433679 0.9107529639428542 0.9652829731961813 0.8384371831971249 1.0 12.321272986436586 -4.864746599990831 3.011540536421688 0.9294526956747466 1.1799221929511707 0.5665833456604469 0.0624791835563705 0.23777560793186944 3.498834267717364 0.016567850509401176 0.1309641794366751 1.3653795691754214e-05 4.864746599990831 0.2504694972764241 SDEGQLS(ph)PATR ddPTM_A459_Selumetinib_30min_R2 3 SDEGQLSPATR 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 SDEGQLS(0.993)PAT(0.007)R;SDEGQLS(0.896)PAT(0.104)R;SDEGQLS(0.997)PAT(0.003)R 119.21 0.0050849 414399300.0 136238.0 113329.0 122200.0 133590.0 144883.0 95559.0 109964.0 118257.0 115972.0 113548.0 True False 128666.43736392514 122020.96988983046 114337.78504129991 115394.81154439609 126681.5022695462 108721.38485176586 115077.54388953214 118601.10829149977 139169.6405284205 110269.57420686557 1.166835351359452 1.1065697021820298 1.036893321332704 1.0464791614041746 1.1488346008473005 0.9859599588895183 1.0436019610781015 1.075556055644182 1.2620855891520761 1.0 16.75067524908207 -11.27395537828925 2.575927871128752 0.9794414931757719 1.0900688776435299 0.12327066204833659 0.07559411202189968 34012581.53386563 25111835.847133435 4446112.503444969 0.018713130258682962 5.321629336907959e-12 11.27395537828925 0.110627384467758 SDES(ph)STEETDKSR ddPTM_A459_Selumetinib_30min_R1 1 SDESSTEETDKSR 13 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y815 A0A0C4DG98 THOC2 THO complex subunit 2 1 SDES(0.492)S(0.492)T(0.017)EETDKSR 255.15 6.5529e-23 3289300.0 1112.1 1257.3 1656.7 2017.5 1520.2 1560.2 1426.2 1345.8 883.34 862.01 True False 1138.009766230093 1110.0947314970872 1431.7292396017015 1665.1814981653854 1382.698178413109 1544.5058045482572 1318.6205857597934 1310.1050122255103 1498.9634633990224 972.657380188443 1.1700006491593316 1.1413008877617492 1.4719769455965241 1.7119918401716878 1.4215675597353967 1.5879238013379635 1.3556886655240548 1.3469337085291946 1.5411012078154516 1.0 9.92578789308429 -10.83553470516768 3.5210006741342985 0.9984203014083691 1.4200835061411208 0.35741661870548547 0.16747537993010464 65769847.52805783 95142875.64251621 1090540.5366160441 0.04522376188606732 1.460378043629994e-11 10.83553470516768 0.42166320473275165 SDGAPAS(ph)DSKPGSSEAAPSSK ddPTM_A459_Selumetinib_30min_R1 1 SDGAPASDSKPGSSEAAPSSK 21 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 S(0.001)DGAPAS(0.418)DS(0.339)KPGS(0.145)S(0.034)EAAPS(0.051)S(0.012)K 92.416 0.00032511 33792000.0 1057.1 1326.2 1381.7 1694.3 1480.6 1029.8 1147.1 1171.7 615.74 1027.2 True False 1081.7283732414628 1170.9278874663462 1194.072729134828 1398.4223109499926 1346.6799914211606 1019.4411469835882 1060.5733234644918 1140.6227097820108 1044.8658081297276 1159.0511257753021 0.9332878845338964 1.0102469696348377 1.0302157537150052 1.2065234050953295 1.1618814403207205 0.8795480409042981 0.9150358425777487 0.984100428718393 0.901483795575286 1.0 10.17872848972581 -6.771047616154952 24.99928045018834 0.9337275340085798 1.0707473660159066 0.4130656614547118 0.07886237271401571 221.39985027018787 576047.7177367152 0.03033870270509872 0.02709209221210766 1.6941520430131427e-07 6.771047616154952 0.13701983200732681 SDGAPASDSKPGS(ph)SEAAPSSK ddPTM_A459_Selumetinib_30min_R1 2 SDGAPASDSKPGSSEAAPSSK 21 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 SDGAPASDSKPGS(0.813)S(0.152)EAAPS(0.029)S(0.006)K;SDGAPASDSKPGS(0.79)S(0.166)EAAPS(0.036)S(0.008)K 134.69 2.1578e-05 25318000.0 6105.5 6247.5 7994.1 7064.9 6931.0 6364.0 5805.799999999999 7059.9 3561.6000000000004 5044.0 True False 6247.746270765073 5516.039795616047 6908.545128448094 5831.147839597833 6304.092273767437 6299.983938049674 5367.8638317236055 6872.648518212867 6043.775071028094 5691.446532720622 1.097743119406681 0.9691806404406778 1.2138469699627796 1.0245458348899628 1.1076432392933258 1.1069213954362074 0.9431457891879136 1.207539854534592 1.0619049192998484 1.0 12.474579657819088 -8.543354746595394 23.135244017498653 0.9999999942751214 1.0827009077287246 0.08354776883934445 0.08364422695795401 4650.004843711747 5253901.3118078 0.07595278232987526 0.019610924250480395 2.8618393665775195e-09 8.543354746595394 0.0827009134536032 SDGAPASDSKPGS(ph)SEAAPSSK ddPTM_A459_Selumetinib_30min_R2 1 SDGAPASDSKPGSSEAAPSSK 21 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 SDGAPASDS(0.001)KPGS(0.678)S(0.216)EAAPS(0.089)S(0.016)K 68.411 0.0042658 9086000.0 49568.0 33950.0 41349.0 38104.0 27616.0 23044.0 48880.0 35533.0 25061.0 31425.0 True False 46813.208996425674 36553.855833544316 38688.650357387225 32914.16946693368 24146.631189827585 26218.10182739559 51153.01685388252 35636.39514719517 30073.900262845684 30517.678598044473 1.5339701821037395 1.1977928044594661 1.267745521111371 1.078527954254121 0.7912342058473237 0.8591119322252645 1.676176537790798 1.1677295516664463 0.9854583193877916 1.0 14.897357603764366 -4.2641441573122 1.1663918595692697 1.1020410403343972 2.3814219745110488 0.2437578578545463 0.23146237122974744 7.5384538998050425 3.767449985700861 0.0752816808680039 15.761945109889806 5.443219436319846e-05 4.2641441573122 1.2793809341766516 SDGAPASDSKPGSSEAAPS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 SDGAPASDSKPGSSEAAPSSK 21 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 1 SDGAPASDSKPGS(0.022)S(0.062)EAAPS(0.738)S(0.178)K 73.649 0.046421 0.0 1128.5 1317.1 1561.0 1355.9 958.03 1337.8 1234.9 1459.8 660.94 1060.9 True False 1154.7918543212481 1162.8933196968214 1349.0247739592294 1119.1175183952637 871.3763556539342 1324.3429466252132 1141.750498776306 1421.0813619013236 1121.566906852345 1197.0768490411008 0.9646764576946548 0.9714441646986478 1.1269324730821118 0.9348752498987135 0.7279201467741493 1.1063140580206332 0.95378212325373 1.187126259303785 0.936921391263024 1.0 10.225300056969944 SDGAPASDSKPGSSEAAPSSK ddPTM_A459_Selumetinib_30min_R2 2 SDGAPASDSKPGSSEAAPSSK 21 1 P80723;P80723-2 P80723 BASP1 Brain acid soluble protein 1 0 ; 134.04 0.00015318 2187700.0 18996.0 13105.1 16491.1 16083.599999999999 13708.7 11867.900000000001 17504.8 13977.5 9956.400000000001 13110.0 False True 17940.278367013023 14110.219030461909 15430.08058015207 13892.985934242452 11986.490548667047 13502.595498930224 18318.807885103157 14018.172210900313 11947.958205059524 12731.480236129288 1.409127456845297 1.1082936758932436 1.2119628113913037 1.0912310019393545 0.9414844406428001 1.0605676047481638 1.438859232810824 1.101063815904113 0.9384578999033991 1.0 13.63611254467825 -2.4322666400166892 1.3468013763223559 1.1029892474062217 199.9999959413306 0.30646082677025455 0.13854952889991426 1305.2652226410528 4.837572693835438 0.04175669646878791 799444.9078279661 0.003696011892688436 2.4322666400166892 198.8970066939244 SDGEAKPEPS(ph)PSPR ddPTM_A459_Selumetinib_30min_R1 1 SDGEAKPEPSPSPR 14 1 P26358;K7EJL0;K7ERQ1;K7ENQ6 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 SDGEAKPEPS(0.865)PS(0.135)PR 156.49 0.0015212 6758600.0 693.62 1156.8 1031.0 1102.0 970.22 685.09 1033.9 926.44 389.99 772.86 True False 709.7799964504248 1021.3613182182702 890.9958628776211 909.556387101985 882.4637723062532 678.1986166119505 955.9120906023347 901.867801698768 661.7845462573692 872.0641092939053 0.8139080474543563 1.1711998089741913 1.0217091305351902 1.0429925706246947 1.0119253423016896 0.7776935312256753 1.0961488730184294 1.0341760337195784 0.7588714398454081 1.0 9.768290387575812 -6.552715238463038 24.99920646060274 0.9400340886558141 1.024828663798435 0.08336276931702091 0.1273799362905746 520.2321502021362 435885.2279823498 0.040980756617332206 0.04098122148356669 2.800817178983791e-07 6.552715238463038 0.0847945751426209 SDGEAKPEPS(ph)PSPR ddPTM_A459_Selumetinib_30min_R2 1 SDGEAKPEPSPSPR 14 1 P26358;K7EJL0;K7ERQ1;K7ENQ6 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 SDGEAKPEPS(0.655)PS(0.345)PR 101.2 0.040148 2279700.0 6234.3 5157.6 6539.6 7302.7 5367.8 5305.4 5644.3 4590.6 5204.1 5933.0 True False 5887.822563880259 5553.171335702155 6118.8492557781165 6308.059662139836 4693.448975259145 6036.170692373915 5906.771133968271 4603.957885985262 6245.065414703131 5761.698874214728 1.0218900175831769 0.9638079769413508 1.0619869919203415 1.0948263350537515 0.8145946321949746 1.0476373070080993 1.0251787299059976 0.7990625658326761 1.0838930584608661 1.0 12.492278547029125 SDGEAKPEPSPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SDGEAKPEPSPSPR 14 1 P26358;K7EJL0;K7ERQ1;K7ENQ6 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 SDGEAKPEPS(0.214)PS(0.786)PR 157.37 0.0014897 7235600.0 703.73 983.84 844.73 1159.7 984.85 919.69 903.75 864.93 534.79 788.64 True False 720.1255397797893 868.6515554251932 730.0203057697498 957.1801652651291 895.7704913893898 910.4387536117081 835.579409886701 841.9892467114065 907.4995704838036 889.8696260041224 0.8092483648570484 0.9761559784052783 0.8203677082988423 1.0756408998509797 1.0066311572086852 1.023114765361696 0.9389908200809071 0.946193939096766 1.0198118285695925 1.0 9.797450173387375 -5.755843420400274 24.99998762639651 0.9977533720192089 0.8793472172408777 0.5404619700652982 0.05581748927479062 115.75958434944673 517149.5668665944 0.015084283644813522 0.025214563927187673 1.7545129561559122e-06 5.755843420400274 -0.11840615477833116 SDGEAKPEPSPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SDGEAKPEPSPSPR 14 1 P26358;K7EJL0;K7ERQ1;K7ENQ6 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 SDGEAKPEPS(0.001)PS(0.999)PR 145.94 0.0024088 2625300.0 6222.3 6431.3 6253.0 5684.7 6993.5 5870.4 5070.7 5423.0 4742.4 7622.5 True False 5876.489475840449 6924.5600301111535 5850.688787751634 4910.434053345523 6114.914007316745 6678.994313814572 5306.497597401433 5438.780032174019 5691.012513727281 7402.4186193665555 0.7938607336345584 0.935445613950391 0.7903752933459866 0.6633553580040198 0.8260697377095939 0.9022719002057885 0.7168599710800366 0.7347301350865009 0.7688044686959727 1.0 12.853781009466244 -5.40548797543511 12.051287005642951 0.7873192317889844 0.864568019824204 0.05353628324035209 0.09664994585278348 1.3835795087060363 135.22510980590147 0.02462667870424212 0.05127861401872204 3.9310812897107866e-06 5.40548797543511 0.0772487880352195 SDGIYIINLK ddPTM_A459_Selumetinib_30min_R1 2 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 ; 140.09 0.02017 131224000.0 7263.200000000001 8797.8 5959.2 6069.0 7121.9 6825.7 7524.0 7260.799999999999 3846.6 6557.3 False True 7432.418428273009 7767.7494860137385 5149.973371542499 5009.163079239517 6477.725402473567 6757.039655239737 6956.45862239285 7068.219997597701 6527.399255451673 7398.993328510889 1.0045175199217062 1.0498386930667858 0.696037034078388 0.6770060272844785 0.8754873960370585 0.9132377007561986 0.9401898763156334 0.9552948196832934 0.882200992167318 1.0 12.853113282598471 -6.800343680649719 3.451298418846775 0.9383029601091676 0.850811916850988 0.10965682120553866 0.11183097596127571 0.619668687364835 15.251757066181149 0.04582947860344468 0.0417093280247851 1.5836394771192396e-07 6.800343680649719 -0.08749104325817958 SDGS(ph)ENLCTPQQSR ddPTM_A459_Selumetinib_30min_R1 3 SDGSENLCTPQQSR 14 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 S(0.001)DGS(0.998)ENLCT(0.001)PQQSR;S(0.009)DGS(0.987)ENLCT(0.004)PQQSR;S(0.003)DGS(0.997)ENLCTPQQSR 135.61 0.00060186 19543000.0 6104.6 5769.1 7168.5 7885.099999999999 6172.4 6042.299999999999 5365.9 5019.5 3488.76 4998.200000000001 True False 6246.825302516165 5093.651090018172 6195.0570737519165 6508.115306658673 5614.107509825731 5981.519947969445 4961.145842889123 4886.366554366143 5920.17091105121 5639.767656590842 1.1076387686318765 0.9031668324253646 1.0984596265259514 1.1539686921416075 0.9954501411533995 1.0605968742310188 0.879672026398347 0.866412741073784 1.0497189372921556 1.0 12.461420013316516 -7.245194396542084 24.32240344232814 0.9378186547292786 1.0504040132188504 0.27911197788881925 0.08122896307807277 717.5748129197518 1074372.7244101015 0.03129861074202798 0.02416307416431058 5.6859836095700524e-08 7.245194396542084 0.11258535848957174 SDGS(ph)ENLCTPQQSR ddPTM_A459_Selumetinib_30min_R2 2 SDGSENLCTPQQSR 14 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 S(0.002)DGS(0.988)ENLCT(0.01)PQQSR;SDGS(0.999)ENLCT(0.001)PQQSR 135.23 0.00060496 26712000.0 46551.4 44713.8 38026.1 45428.8 46178.0 33568.8 41492.5 44177.0 36252.7 35454.0 True False 43964.259548019094 48143.20468247227 35579.54212568724 39241.3190709489 40376.70680344211 38192.59749277372 43421.98346582896 44305.54775610394 43504.25298507105 34430.3508994453 1.2769041964288372 1.3982780722472363 1.0333772731389868 1.1397304426421373 1.1727068051488436 1.1092712242264435 1.2611542529044781 1.2868166196011013 1.2635437005021037 1.0 15.071393263864477 -5.244331793520988 24.995211176415562 1.1703385767997658 1.3375911421348845 0.35755279088690417 0.09503313299540067 976.6109685426552 1426882.5078284284 0.024805873510867854 0.06525813190316622 5.697288429262325e-06 5.244331793520988 0.16725256533511867 SDGSDTTEQESTNLPS(ph)PNK ddPTM_A459_Selumetinib_30min_R1 2 SDGSDTTEQESTNLPSPNK 19 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 SDGSDTTEQESTNLPS(1)PNK;SDGSDTTEQESTNLPS(1)PNK 310.08 9.317199999999997e-117 7415100.0 5008.200000000001 5522.0 5556.4 6036.6 4728.7 4382.8 5073.1 5002.6 2915.2 4333.799999999999 True False 5124.881315739188 4875.481672891843 4801.871399120473 4982.421131016189 4300.989919919791 4338.713011264003 4690.43198262376 4869.914797265076 4946.881482216166 4890.085444786802 1.0480146765539027 0.9970135957623137 0.981960633068207 1.018882223485036 0.87953267248223 0.8872468712973914 0.95917178453888 0.9958751952804363 1.0116145286356728 1.0 12.255643958365818 -4.957232973039501 1.0794075792842037 0.9575990628329148 1.0687889725154653 0.23548384584857807 0.045576600952037666 2.1106675689831444 2.4786473342133775 0.016444482726177254 0.2514763059431125 1.1034865065245184e-05 4.957232973039501 0.11118990968255049 SDGSDTTEQESTNLPS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 3 SDGSDTTEQESTNLPSPNK 19 0 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 SDGSDTTEQES(0.005)T(0.131)NLPS(0.864)PNK;SDGSDTTEQESTNLPS(1)PNK;SDGSDTTEQEST(0.011)NLPS(0.989)PNK 265.43 4.7148e-48 33241400.0 195949.0 192320.0 197254.0 209254.0 200581.0 155652.0 175346.0 174581.0 122674.0 196985.0 True False 185058.93902599683 207070.32559373282 184562.8923939167 180753.24421671618 175382.22156310847 177091.65013182533 183499.93644150757 175089.00180655954 147212.22779794608 191297.5312215052 0.9673880151214046 1.0824516357922265 0.9647949516933891 0.9448801720677739 0.9168033713933912 0.9257393391385133 0.9592383930403748 0.9152705771399755 0.7695458841415348 1.0 17.545458729629075 -5.659182506530706 2.1837431881924436 0.9144993462259755 1.025107860685244 0.3158331952545844 0.06181274647661215 0.350840431403198 3.381045294150891 0.018028831475514 0.03806949620604018 2.1918836315806057e-06 5.659182506530706 0.11060851445926845 SDGSENLCT(ph)PQQSR ddPTM_A459_Selumetinib_30min_R1 1 SDGSENLCTPQQSR 14 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 S(0.002)DGS(0.029)ENLCT(0.969)PQQSR 163.64 0.00062345 5347100.0 1249.9 1657.6 1575.4 1662.6 1607.3 1287.2 1624.2 1499.3 829.85 1507.7 True False 1279.0202381179693 1463.5274214026663 1361.469333052768 1372.2581208672955 1461.9199987918635 1274.2519366840895 1501.6852863490785 1459.533693587241 1408.1948401540494 1701.227981241649 0.751821773578207 0.8602770689995964 0.8002862332766789 0.8066279981274154 0.8593322087994781 0.7490189150040143 0.8827066700684446 0.8579295130814822 0.8277519860249841 1.0 10.732360773909916 -14.52287874527675 0.19699470868673394 1.7976191133243091 0.7940607124592969 0.6496489785686319 0.04076081179332482 84.14800792368622 0.8276758080872635 26.31488992847101 0.09655618666135764 3.000000000024788e-15 14.52287874527675 -1.0035584008650122 SDGSENLCT(ph)PQQSR ddPTM_A459_Selumetinib_30min_R2 2 SDGSENLCTPQQSR 14 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 SDGSENLCT(0.983)PQQS(0.017)R;SDGSENLCT(0.999)PQQS(0.001)R 133.48 0.0016913 24877600.0 32492.0 36286.0 36588.0 42915.0 43162.0 31429.0 29061.0 27974.0 29005.0 35652.0 True False 30686.224715781613 39069.01952212045 34233.96791400234 37069.902967495764 37739.60368682425 35758.0594659441 30412.39408327903 28055.399708655004 34806.81046741305 34622.634124979515 0.8863053170654666 1.1284242377714686 0.9887742160352624 1.070684074287421 1.0900269329766539 1.0327943083956572 0.8783963107341135 0.8103196194541886 1.005319535820663 1.0 15.079427870125704 -7.2504221546902725 22.099923708128937 0.9077021738388251 1.039497165236724 0.29379344951444286 0.08118474545342692 156.23824952001368 313405.6177164757 0.029854109584673424 0.0228305537275263 5.6179496852303625e-08 7.2504221546902725 0.13179499139789885 SDGSGESAQPPEDSS(ph)PPASSESSSTR ddPTM_A459_Selumetinib_30min_R1 2 SDGSGESAQPPEDSSPPASSESSSTR 26 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 SDGSGESAQPPEDS(0.223)S(0.773)PPAS(0.001)S(0.001)ESSSTR;SDGSGESAQPPEDS(0.066)S(0.932)PPAS(0.001)SESSSTR 166.45 3.5535e-17 16934300.0 3042.11 3566.7200000000003 3840.1000000000004 3769.7400000000002 3721.32 3452.2200000000003 3397.69 2986.43 1753.51 2940.5200000000004 True False 3112.985244084373 3149.1267642768566 3318.6355121594074 3111.4256757838793 3384.7272630524076 3417.493801164969 3141.3995078040857 2907.220175108213 2975.578398696788 3317.964385090335 0.9382214161408543 0.9491140949034383 1.0002022707272231 0.9377513784552476 1.0201216379121125 1.0299971321337509 0.9467851800701466 0.8762059617553914 0.8968084202675295 1.0 11.696082685202603 -7.52275943761591 24.999978568229846 0.9142034159183549 0.9795914797344045 0.24572068253789103 0.042551876199089796 5.262233352990301 1103415.425052508 0.019844301460752983 0.011607700124291126 3.000824261362499e-08 7.52275943761591 0.06538806381604967 SDGSGESAQPPEDSS(ph)PPASSESSSTR ddPTM_A459_Selumetinib_30min_R2 1 SDGSGESAQPPEDSSPPASSESSSTR 26 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 SDGSGESAQPPEDS(0.055)S(0.944)PPASSESSSTR 172.65 1.0912e-17 5213900.0 15677.0 14244.0 16941.0 18140.0 18249.0 14705.0 15267.0 15152.0 12241.0 14753.0 True False 14805.735100003327 15336.468998321212 15851.034503966168 15669.30070675458 15956.397471870054 16730.48027130065 15976.945750986579 15196.089811451366 14689.542042116984 14327.042557102615 1.0334118183144085 1.0704560230902767 1.106371705171493 1.0936870358486193 1.1137258375741814 1.1677553273551584 1.1151600679140878 1.060657825987815 1.0253017664720105 1.0 13.80645321325666 -8.143168561521255 2.334736848245601 1.0065264687700868 1.1017048287486806 0.531323601204413 0.032808583353149304 0.26423702925605386 2.5695513207968004 0.03209863721559107 0.00987154830759994 7.191697944360403e-09 8.143168561521255 0.09517835997859381 SDHTLTS(ph)PGGGGK ddPTM_A459_Selumetinib_30min_R1 2 SDHTLTSPGGGGK 13 0 C9J0Q5;Q9Y618;Q9Y618-4 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SDHTLT(0.045)S(0.955)PGGGGK;SDHTLT(0.029)S(0.971)PGGGGK 109.99 0.0038007 65034000.0 20383.2 21457.9 19819.2 23143.0 33071.0 19879.5 27448.0 19404.4 5648.200000000001 12664.4 True False 20858.088901197054 18945.599092492932 17127.86149907288 19101.509497914005 30079.733889159274 19679.53027914181 25377.575261488433 18889.73227762573 9584.582871793831 14289.999101702426 1.4596284263385395 1.3257942815570831 1.1985908030625674 1.3367047374858383 2.104950019596275 1.3771540599185417 1.7758976106908992 1.321884777121877 0.6707196273127813 1.0 13.802718205292521 -10.640076810077792 9.571203633068869 0.9999999985210529 1.416322038784891 0.10079552107461165 0.35123995993149226 1.12176170936037e-08 1.084378704630919e-09 0.34825504815931485 0.08446425514806996 2.2904625217554738e-11 10.640076810077792 0.416322040263838 SDHTLTS(ph)PGGGGK ddPTM_A459_Selumetinib_30min_R2 4 SDHTLTSPGGGGK 13 0 C9J0Q5;Q9Y618;Q9Y618-4 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SDHTLT(0.074)S(0.926)PGGGGK;SDHTLT(0.186)S(0.814)PGGGGK;SDHTLT(0.189)S(0.811)PGGGGK;SDHTLT(0.15)S(0.85)PGGGGK 98.676 0.0081774 98898000.0 270509.0 240947.0 424323.0 544880.0 639990.0 383047.0 276179.0 374677.0 368661.0 493688.0 True False 255475.19271332546 259426.86013328392 397022.52014795016 470666.4040295726 559588.7346168068 435808.247295539 289021.87073830655 375767.24803888344 442403.5012489897 479433.94468453166 0.5328683868669929 0.5411107473918795 0.8281068217003109 0.981712724448979 1.1671863054774254 0.90900582265259 0.6028398154587978 0.7837727224052501 0.9227621576525875 1.0 18.87097253213966 -5.311841251900095 3.69031907198635 0.8987265189387625 0.5291311678002957 0.5285712343999984 0.1383219836880713 0.1979722776655706 5.531719064969429 0.0419891512227109 0.10339693183798918 4.877067294580101e-06 5.311841251900095 -0.36959535113846687 SDHYTIQR ddPTM_A459_Selumetinib_30min_R1 1 SDHYTIQR 8 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7;F8WA26 Q8WX93 PALLD Palladin 0 96.492 0.029554 1366400.0 2975.7 3277.4 3093.1 3242.0 5555.5 3189.9 4182.8 3165.6 634.8 1785.8 False True 3045.0280202957347 2893.680484378076 2673.0740091821226 2675.8455598771625 5053.006005903186 3157.812502197466 3867.288028408398 3081.63800468203 1077.2092360424058 2015.0248251650464 1.5111615411717436 1.4360520268731978 1.3265712540108168 1.3279466964671216 2.5076643934097955 1.5671332991834561 1.9192259966780492 1.5293300440750746 0.534588568135469 1.0 10.976581897570108 -8.178313715696566 5.582507259661837 0.7739186051712507 1.6549504657460459 0.5048595414637105 0.34693013962704883 0.17549279965756434 8.824575951375207 0.2557524342855739 0.09237136246080142 6.632637840202853e-09 8.178313715696566 0.8810318605747952 SDHYTIQR ddPTM_A459_Selumetinib_30min_R2 2 SDHYTIQR 8 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7;F8WA26 Q8WX93 PALLD Palladin 0 ; 132.76 0.0045428000000000005 3227000.0 32801.0 29766.0 47783.0 68033.0 74812.0 47846.0 36263.0 43829.0 48501.0 59476.0 False True 30978.051732806627 32048.95648722476 44708.693802196765 58766.788036528895 65413.44773223431 54436.35219725611 37949.30135377131 43956.535133718426 58202.555231167054 57758.7733427937 0.5363350005540175 0.554875989090294 0.7740589215226965 1.0174521485723513 1.1325283406558988 0.942477636673146 0.6570309436550054 0.761036507351704 1.0076833676113506 1.0 15.817752482732631 -5.405020780414828 3.123506131287044 0.918061162216311 0.5413722090770694 0.5834191374760302 0.1288961656283619 0.20612776798797902 3.7606423332581667 0.03999211751422549 0.09561313507295598 3.93531245057255e-06 5.405020780414828 -0.37668895313924156 SDIS(ph)PLTPR ddPTM_A459_Selumetinib_30min_R1 4 SDISPLTPR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.056)DIS(0.944)PLTPR;S(0.003)DIS(0.974)PLT(0.023)PR;S(0.363)DIS(0.637)PLTPR;S(0.002)DIS(0.998)PLTPR 121.61 0.0062081 554760000.0 9595.8 12284.400000000001 11991.599999999999 13627.899999999998 13010.9 10591.8 10371.5 9439.5 5730.08 9197.3 True False 9819.363469823513 10846.136737137376 10363.206585143816 11248.04309236582 11834.066392260967 10485.256108584937 9589.169404857446 9189.133796182721 9723.527251515237 10377.863044288535 0.9461835666859766 1.0451223619786114 0.9985877189665955 1.083849636901519 1.1403182275347 1.0103482830557786 0.9240023079833235 0.8854552962365376 0.9369488891903028 1.0 13.341221781549589 -7.1621395191584964 4.247295032998712 0.9271202164827911 1.0451526063541028 0.45063598790568693 0.054741703632855764 0.2028954380489853 6.343139535183277 0.02262138902735667 0.017180687832154713 6.884310990658618e-08 7.1621395191584964 0.1180323898713117 SDIS(ph)PLTPR ddPTM_A459_Selumetinib_30min_R2 1 SDISPLTPR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.011)DIS(0.988)PLTPR 82.831 0.040344 9221100.0 20447.0 18911.0 19347.0 22221.0 19589.0 10666.0 16934.0 18199.0 12102.0 17264.0 True False 19310.637595826254 20361.41289155102 18102.23508342089 19194.461466636916 17128.054692118072 12135.144683692133 17721.464554084418 18251.95607699337 14522.738158132497 16765.54346274111 1.151805048177605 1.2144797415485629 1.0797284993266323 1.1448755901825498 1.0216223965648707 0.7238145730653266 1.0570170059484023 1.088658779093895 0.8662253144615975 1.0 14.03321162905715 -6.36895503673115 4.151884913188671 0.9522146753423498 1.1476927105307568 0.4640677408677334 0.1009143695630749 0.22514686112265916 6.675843888076233 0.03316795270898218 0.0379460534995586 4.276071547780948e-07 6.36895503673115 0.195478035188407 SDISPLT(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 SDISPLTPR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SDISPLT(1)PR;SDISPLT(1)PR;SDISPLT(1)PR;SDISPLT(1)PR 123.11 0.006620399999999999 1572555000.0 16299.6 19836.6 21886.100000000002 23215.0 20392.699999999997 18852.8 20928.1 17869.0 11431.900000000001 13888.0 True False 16679.34896649944 17514.12165021486 18914.087831741894 19160.936049521402 18548.18388562361 18663.15794897281 19349.476567690017 17395.056073307802 19399.099347059215 15670.66008057573 1.0643679896530978 1.1176377740414494 1.2069745457108405 1.2227267997007973 1.1836249264710081 1.1909618263053496 1.2347582340627945 1.1100397803197528 1.2379248383483858 1.0 13.935778329935347 -5.021218130508107 3.494921450912436 1.182004270821211 1.0691064542822426 0.19773037380562386 0.06836633971427442 0.309366389639715 7.730421248393987 0.01620430207469889 0.06721977379778415 9.523177289179245e-06 5.021218130508107 -0.11289781653896847 SDISPLT(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SDISPLTPR 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SDIS(0.001)PLT(0.999)PR;SDISPLT(1)PR 123.11 0.013402 897860000.0 233975.0 202822.0 215404.0 243728.0 234893.0 177079.0 184146.0 190468.0 179092.0 228596.0 True False 220971.60617613554 218377.79522448144 201545.1411541429 210531.8259457491 205383.64136993638 201470.02488688543 192709.1538783765 191022.23034632503 214915.40424857536 221995.83951626354 0.9953862498398175 0.9837021977543996 0.9078780106569412 0.9483593314383958 0.9251688762162132 0.9075396427513932 0.8680755202363084 0.8604766231771233 0.968105549711577 1.0 17.760173113329763 -5.218982943172387 5.492752609937579 0.9166147003725643 0.9912891157799683 0.29015983230106535 0.04050691953278255 0.22480633813384562 17.461497087884165 0.010386111524474051 0.0278821445389771 6.0397234980199886e-06 5.218982943172387 0.07467441540740394 SDKGS(ph)PGEDGFVPSALGTR ddPTM_A459_Selumetinib_30min_R1 2 SDKGSPGEDGFVPSALGTR 19 1 G3V238;A0A494BZY7;Q5JPI9 G3V238 METTL10 Protein-lysine N-methyltransferase METTL10 1 S(0.124)DKGS(0.876)PGEDGFVPSALGTR;S(0.393)DKGS(0.607)PGEDGFVPSALGTR 92.39 0.0012438 34231000.0 5575.5 6574.299999999999 7285.5 7604.0 6445.5 6238.299999999999 6745.1 5864.4 3494.6 5682.9 True False 5705.398301965549 5804.5778996908475 6296.169116386914 6276.10414475816 5862.505663045447 6175.548365923206 6236.311676488835 5708.857061744157 5930.080964514485 6412.35557113363 0.8897507692258089 0.9052177215220562 0.9818808465223372 0.9787517356353677 0.9142514943239531 0.9630701693654584 0.9725461427252585 0.8902901591177511 0.924789790386829 1.0 12.646638711166444 -5.0932368837701745 6.214043520695021 0.9497511612773547 0.8933627990678294 0.32053969855084097 0.03245787868285187 0.2647676396576385 14.259411724259563 0.008502289874126696 0.023474662956400633 8.067948479656429e-06 5.0932368837701745 -0.056388362209525256 SDKGS(ph)PGEDGFVPSALGTR ddPTM_A459_Selumetinib_30min_R2 2 SDKGSPGEDGFVPSALGTR 19 1 G3V238;A0A494BZY7;Q5JPI9 G3V238 METTL10 Protein-lysine N-methyltransferase METTL10 1 S(0.065)DKGS(0.935)PGEDGFVPSALGTR;S(0.024)DKGS(0.975)PGEDGFVPSALGTR 71.042 0.008253700000000001 10665500.0 18985.6 18839.3 21699.0 21190.2 23760.0 15254.8 19760.5 18744.7 15407.2 21504.1 True False 17930.456357378524 20284.21373210284 20302.909964084873 18304.058204866098 20775.056382904957 17356.010230713164 20679.402404687917 18799.243973647863 18489.07051313658 20883.220758638286 0.8586058905670305 0.9713163484953502 0.9722116238074354 0.8764959397986862 0.9948205127464073 0.8310983459547971 0.990240090055742 0.9002080757045873 0.885355315965265 1.0 14.350056611293608 SDKNQQGFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SDKNQQGFSPK 11 1 C9JKA9;Q9NS87-4;Q9NS87-2;Q9NS87;D6RCT7 C9JKA9 KIF15 Kinesin-like protein KIF15;Kinesin-like protein 1 SDKNQQGFS(1)PK;SDKNQQGFS(1)PK 87.863 0.017299000000000002 87092000.0 9544.599999999999 10677.1 16050.0 16434.699999999997 11454.599999999999 12836.7 11574.400000000001 12118.3 8827.2 11677.599999999999 True False 9766.970609441363 9427.020168350879 13870.498156339292 13564.688162527205 10418.533452473886 12707.574452791063 10701.333689397105 11796.883318214006 14979.11368682031 13176.533709456446 0.7412397543089705 0.7154400676397434 1.0526666923323549 1.0294580093391474 0.7906884831931773 0.9644095126225175 0.8121508983593343 0.8952948915349185 1.136802289366148 1.0 13.685683276610996 -5.24578472475963 24.807382900433893 0.9477290752803929 0.7283398592497445 0.45245363099397984 0.10127983255369705 703.5258743517679 1114848.0025688896 0.026249649715190233 0.06892228368648014 5.678260010806101e-06 5.24578472475963 -0.21938921603064832 SDKNQQGFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SDKNQQGFSPK 11 1 C9JKA9;Q9NS87-4;Q9NS87-2;Q9NS87;D6RCT7 C9JKA9 KIF15 Kinesin-like protein KIF15;Kinesin-like protein 1 SDKNQQGFS(1)PK 63.727 0.047032 50630000.0 84557.0 79847.0 84013.0 73608.0 61065.0 53986.0 67639.0 53848.0 40327.0 77138.0 True False 79857.66044849032 85971.00815142911 78607.69504643812 63582.46341911749 53393.46877197352 61422.08146388551 70784.34752413577 54004.68876498368 48393.5268305246 74910.82551140679 1.0660363158904218 1.1476446503494768 1.0493502709360532 0.8487753670453905 0.7127603841963164 0.8199359844797421 0.9449147975729799 0.7209196854566807 0.6460151319939151 1.0 16.19288660001024 -5.750553045087139 3.3000013034586484 0.7993240385948832 1.10524073470585 0.6101912703542587 0.10138651669111191 0.15224442610027558 3.442916643560168 0.029170684471757146 0.05067237843551615 1.776016330936999e-06 5.750553045087139 0.3059166961109667 SDKS(ph)PDLAPTPAPQSTPR ddPTM_A459_Selumetinib_30min_R1 3 SDKSPDLAPTPAPQSTPR 18 1 F8WAE5;Q9BY44-4;Q9BY44-3;Q9BY44;Q9BY44-2 F8WAE5 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 S(0.003)DKS(0.997)PDLAPTPAPQSTPR;S(0.017)DKS(0.983)PDLAPTPAPQSTPR;S(0.444)DKS(0.553)PDLAPT(0.002)PAPQSTPR 228.19 4.894100000000001e-18 348068000.0 7986.1 8564.0 9704.3 9109.2 7623.599999999999 7789.000000000001 7747.2 7720.200000000001 4661.4 6445.7 True False 8172.160591754474 7561.322898704415 8386.509361904262 7518.4492208615275 6934.046726055896 7710.649731846154 7162.822466693495 7515.435217256197 7910.055344814235 7273.06838143484 1.1236193808674544 1.0396331372334364 1.1530909544741226 1.0337382830131288 0.9533867086628351 1.0601646138139276 0.9848418976751603 1.033323876954054 1.0875815996733045 1.0 12.828348425253465 -5.921835223800957 8.610666613646945 1.0192762378659415 1.0985112225817166 0.42942755998856896 0.04417366690345735 0.2708989606536783 26.811595535190627 0.012087248932921712 0.01796889478982689 1.1971946742397814e-06 5.921835223800957 0.07923498471577517 SDKS(ph)PDLAPTPAPQSTPR ddPTM_A459_Selumetinib_30min_R2 7 SDKSPDLAPTPAPQSTPR 18 1 F8WAE5;Q9BY44-4;Q9BY44-3;Q9BY44;Q9BY44-2 F8WAE5 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 S(0.013)DKS(0.987)PDLAPTPAPQSTPR;S(0.014)DKS(0.986)PDLAPTPAPQSTPR;S(0.016)DKS(0.984)PDLAPTPAPQSTPR;S(0.132)DKS(0.858)PDLAPT(0.006)PAPQS(0.003)T(0.001)PR;S(0.225)DKS(0.775)PDLAPTPAPQSTPR;S(0.109)DKS(0.891)PDLAPTPAPQSTPR;S(0.179)DKS(0.821)PDLAPTPAPQSTPR 148.4 0.00010746 1092440700.0 735139.0 743228.0 755403.0 773690.0 692507.0 522808.0 651098.0 659844.0 460257.0 675456.0 True False 694282.9173745832 800231.1977453162 706801.1934005984 668312.0873103068 605508.0795688711 594820.0564214989 681375.3471262103 661764.0367969462 552321.2606550632 655953.8302345494 1.0584325990235144 1.2199504917277144 1.0775166800197928 1.0188401325003904 0.9230955772487213 0.9068017122619882 1.0387550399432397 1.0088576456064282 0.8420124026984791 1.0 19.32323474776225 -5.775637346148871 2.3937463996917336 0.9567067187837642 1.1397933578346582 0.5645005706210158 0.06546515294094907 0.20315352882030455 2.374507953772921 0.01931298358230195 0.03533275127228445 1.6763421067158009e-06 5.775637346148871 0.18308663905089395 SDLDYIRS(ph)PLPFQNR ddPTM_A459_Selumetinib_30min_R2 2 SDLDYIRSPLPFQNR 15 1 A0A0A0MRF6;Q99996-5;Q99996-3;Q99996;Q99996-1;Q99996-6;H7BYL6 A0A0A0MRF6 AKAP9 A-kinase anchor protein 9 1 SDLDY(0.001)IRS(0.999)PLPFQNR;SDLDYIRS(1)PLPFQNR 74.14699999999998 0.022618 9822700.0 46130.0 40201.0 47430.0 50907.0 51168.0 41282.0 39898.0 47082.0 40609.0 47397.0 True False 43566.27927302123 43284.287433411366 44378.40543787942 43973.37878052678 44739.818392276145 46968.22077931545 41753.33605638716 47219.00082515532 48731.93471026294 46028.525457804695 0.9465060816027953 0.9403796233509798 0.9641500568720591 0.9553505862541282 0.9720019910976742 1.020415499131559 0.907118697396972 1.0258638606279482 1.0587333447154748 1.0 15.490240605539729 -7.890858975029192 8.787992866234186 1.0335638411734775 0.9604594595891155 0.5338051233603247 0.029959343777716856 0.1919875612292945 14.102676171844072 0.016031871809036313 0.007681435092802498 1.2857040885631092e-08 7.890858975029192 -0.07310438158436205 SDLNGLPS(ph)PVEER ddPTM_A459_Selumetinib_30min_R1 2 SDLNGLPSPVEER 13 0 E7EWN3;Q9C0A6 E7EWN3 SETD5 SET domain-containing protein 5 1 SDLNGLPS(1)PVEER;S(0.003)DLNGLPS(0.997)PVEER 131.18 0.0015497 4786700.0 3502.7 4106.299999999999 4334.9 4660.1 3666.8999999999996 3777.5 3638.2 3539.2 2492.5699999999997 3078.0 True False 3584.3060949322416 3625.5324870329223 3746.2443899012596 3846.3010159110363 3335.2295424437757 3739.501779695578 3363.767644868374 3445.3289190582004 4229.709239890077 3473.0912822589353 1.0320218513234616 1.0438920812570287 1.0786484101462093 1.107457507828404 0.9603057539779107 1.0767070243150554 0.9685226708698955 0.9920064401006248 1.2178514459139205 1.0 11.762004613819078 -11.512266100720026 2.894332477994114 0.9545176392901008 1.048817042505884 0.04402663653357619 0.07175953449480234 53590456.00644883 18037.490666861348 16244270.40877944 0.016823730441528524 3.074212607385322e-12 11.512266100720026 0.09429940321578323 SDLNGLPS(ph)PVEER ddPTM_A459_Selumetinib_30min_R2 2 SDLNGLPSPVEER 13 0 E7EWN3;Q9C0A6 E7EWN3 SETD5 SET domain-containing protein 5 1 SDLNGLPS(1)PVEER;S(0.046)DLNGLPS(0.954)PVEER 135.57 0.0011402 15576400.0 56767.0 48425.0 49207.0 59402.0 60296.0 42196.0 43495.0 47543.0 36400.0 48680.0 True False 53612.11739630599 52139.04178908347 46041.07519253071 51311.34512583442 52721.07742692079 48008.1159828495 45517.60368370746 47681.34225883266 43681.01710097693 47274.481914170385 1.1340603899931037 1.1029003318057506 0.9739096723708365 1.0853920137928366 1.1152121671611128 1.015518606211509 0.9628366476093245 1.008606341691929 0.9239872195803732 1.0 15.528774027170224 -6.965479136135998 4.916354964491116 0.9759835849408981 1.0773288865797326 0.559700630378051 0.04543518402119526 0.16091194090331937 9.50563860808325 0.017241202372710374 0.01479180118635482 1.0827317292004194e-07 6.965479136135998 0.10134530163883448 SDLPGSDKDTEESGLHLS(ph)PTAAEAK ddPTM_A459_Selumetinib_30min_R2 1 SDLPGSDKDTEESGLHLSPTAAEAK 25 1 Q15599-2 Q15599-2 SLC9A3R2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 1 SDLPGSDKDT(0.002)EES(0.008)GLHLS(0.918)PT(0.071)AAEAK 59.614 0.0033776 4489900.0 24543.0 23813.0 29546.0 26326.0 29186.0 18161.0 20186.0 18627.0 17202.0 27174.0 True False 23178.998313413398 25639.380529136717 27645.042527252474 22740.353385116945 25519.393753849483 20662.512900856236 21124.68899780018 18681.201486134138 20642.880664038603 26389.416013468894 0.8783444962019269 0.9715781704320638 1.0475806858758345 0.8617224941056102 0.9670313939810051 0.7829848485586152 0.8004985402866948 0.707905073632529 0.7822409049712462 1.0 14.6876718043404 -6.762964783598644 24.99997203508604 0.795580712968635 0.9477585160528903 0.3582483060249909 0.08541595454104092 38.71032664180263 634419.288524632 0.028290756155800012 0.026283641400763242 1.7259778437203713e-07 6.762964783598644 0.15217780308425533 SDPDGGDS(ph)PLPASGGPLTCK ddPTM_A459_Selumetinib_30min_R2 2 SDPDGGDSPLPASGGPLTCK 20 0 Q8N1G0 Q8N1G0 ZNF687 Zinc finger protein 687 1 SDPDGGDS(0.999)PLPAS(0.001)GGPLTCK;SDPDGGDS(1)PLPASGGPLTCK 200.45 9.9363e-16 29335000.0 121679.0 119829.0 121847.0 144113.0 150077.0 107011.0 111083.0 121413.0 96273.0 125007.0 True False 114916.56829963026 129019.49898903658 114007.49667698257 124484.56079120841 131222.9855545971 121750.79390086066 116248.5796067888 121766.29172899593 115530.29009237222 121397.72310280813 0.9466122210736262 1.0627835159624353 0.9391238465027305 1.0254274759814574 1.0809344870782152 1.0029083807260004 0.9575845134125072 1.003036042330676 0.9516676848587435 1.0 16.889381837553536 -8.132653706268028 9.838554083790354 0.9758544926293894 1.0042225880253408 0.0502111792597989 0.04545944246546039 1.1488391425531823 84.70551169552587 0.030630738021666677 0.011552167097060749 7.367943616285303e-09 8.132653706268028 0.02836809539595142 SDPDGGDSPLPAS(ph)GGPLTCK ddPTM_A459_Selumetinib_30min_R1 1 SDPDGGDSPLPASGGPLTCK 20 0 Q8N1G0 Q8N1G0 ZNF687 Zinc finger protein 687 1 SDPDGGDS(0.125)PLPAS(0.874)GGPLT(0.001)CK 95.183 0.0010700999999999998 9281100.0 811.94 985.9 906.54 947.73 893.55 871.1 1032.4 967.56 610.86 740.58 True False 830.856622239782 870.4703696675251 783.4368472677767 782.2267465954304 812.728560269066 862.337524895518 954.5252368099916 941.8971657221836 1036.5848045508264 835.6406568600792 0.9942750097413006 1.0416802515788528 0.9375283991225866 0.9360802878292787 0.9725814003867339 1.031947784991401 1.1422675871188717 1.1271557433088086 1.2404671745458091 1.0 9.706738876080529 -7.10653400682986 2.7694449910727226 1.1394297821895423 0.976069315542208 0.569847538265913 0.06145090187945345 0.19175368712687108 2.8515714288459812 0.025509475385279843 0.01916797308280859 7.824669326747539e-08 7.10653400682986 -0.16336046664733428 SDPES(ph)PIKK ddPTM_A459_Selumetinib_30min_R1 3 SDPESPIKK 9 1 Q8NDI1-3;Q8NDI1-2;Q8NDI1;H7C0Q4 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 S(0.003)DPES(0.997)PIKK;S(0.001)DPES(0.999)PIKK;SDPES(1)PIKK 123.01 0.01035 154690000.0 12670.9 13950.9 15454.9 17005.4 11715.7 12551.0 12796.199999999999 12583.5 7318.5 10852.3 True False 12966.107316720514 12317.52214240254 13356.209467688985 14035.726120893007 10656.017003574832 12424.748335396212 11830.97233172028 12249.74470303144 12418.959977908551 12245.298415353687 1.0588641351902903 1.0058980781520437 1.0907214356607584 1.1462134808649826 0.8702129292507772 1.0146545975406793 0.9661644763908811 1.0003631016188366 1.0141818971383432 1.0 13.579940312055259 -6.2480579737335065 24.999624754034315 0.9788956536796087 1.0715507712944736 0.4700437353961827 0.05081078242309309 772.8945570971346 1443948.482038767 0.015245044650369684 0.019571540151637194 5.648615667168804e-07 6.2480579737335065 0.09265511761486489 SDPGPPTETPSQRPS(ph)PLKR ddPTM_A459_Selumetinib_30min_R2 1 SDPGPPTETPSQRPSPLKR 19 2 P98174 P98174 FGD1 FYVE, RhoGEF and PH domain-containing protein 1 1 SDPGPPTET(0.001)PS(0.108)QRPS(0.891)PLKR 57.197 0.019935 6365900.0 63252.0 55393.0 59747.0 65704.0 56455.0 44549.0 55266.0 51600.0 42759.0 55475.0 True False 59736.707057817846 59641.46498343212 55902.94306761502 56755.00185427798 49362.61818589646 50685.22037444218 57835.97850750145 51750.14745716016 51311.9947862822 53873.29260864016 1.1088371281067257 1.107069237751896 1.037674520354996 1.0534904979090818 0.9162725312612455 0.940822769876763 1.0735556656551146 0.9605900243205203 0.9524570023784442 1.0 15.71728262154087 -5.684454867145603 1.5771580183685352 0.9771750002621769 1.1082675418532555 0.5741867353914364 0.043799710680326336 0.30289088203417636 1.5058598783757056 0.014507956590443351 0.03553809085757391 2.067974279267627e-06 5.684454867145603 0.13109254159107864 SDS(ph)APPTPVNR ddPTM_A459_Selumetinib_30min_R2 1 SDSAPPTPVNR 11 0 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 S(0.228)DS(0.741)APPT(0.031)PVNR 124.39 0.0035881 7253900.0 33352.0 33146.0 38288.0 42643.0 40222.0 28409.0 34010.0 32556.0 26108.0 36738.0 True False 31498.429358634374 35688.1916188118 35824.59176482243 36834.949836721935 35168.952770757714 32322.08187877457 35591.53238953652 32650.732570064065 31330.329518469924 35677.27848321263 0.882870855002448 1.0003058847553157 1.0041290504173157 1.0324484210322833 0.9857521163590407 0.9059570475361008 0.9975966189877277 0.9151688121454484 0.878159177225693 1.0 15.122717948044164 -6.729717700055549 21.944935845028503 0.9377131904939461 0.9863002900379492 0.13976947188794464 0.05086322417137565 94.7959132737473 65578.05698923496 0.016877995986240683 0.01687453222624586 1.8632979233551876e-07 6.729717700055549 0.04858709954400309 SDS(ph)ASSEPVGIYQGFEK ddPTM_A459_Selumetinib_30min_R2 1 SDSASSEPVGIYQGFEK 17 0 Q05655;Q05655-2 Q05655 PRKCD Protein kinase C delta type;Protein kinase C delta type regulatory subunit;Protein kinase C delta type catalytic subunit 1 S(0.051)DS(0.948)ASSEPVGIYQGFEK 148.36 0.00038571 0.0 6165.2 4732.3 6098.2 7763.1 7745.0 4665.8 6004.1 7184.3 4060.4 3438.2 True False 5822.56286525104 5095.252193257198 5705.848451218137 6705.7523879055425 6772.0038588215 5308.471598084638 6283.302546898447 7205.2051235751105 4872.593457055128 3338.9302324835803 1.7438408291987795 1.52601337508847 1.7088851979317887 2.0083535506872914 2.0281956756503754 1.5898719734961526 1.8818310385074348 2.157938208315212 1.4593277240868763 1.0 11.705170233019231 -8.536263826447238 7.633692886745349 1.0000214380171568 1.8221419287745957 0.6584696650304547 0.18817517479857188 0.10742281953975541 51.08443871031979 0.1922824343816921 0.049715804046303894 2.908949444322149e-09 8.536263826447238 0.8221204907574389 SDS(ph)DSSTLAK ddPTM_A459_Selumetinib_30min_R1 1 SDSDSSTLAK 10 0 Q6AWC2-3;Q6AWC2-2;Q6AWC2-4;Q6AWC2;Q6AWC2-6;Q6AWC2-7 Q6AWC2-3 WWC2 Protein WWC2 1 S(0.008)DS(0.949)DS(0.014)S(0.014)T(0.014)LAK 100.69 0.017159999999999998 18100000.0 2256.0 2117.3 2287.7 2252.3 2349.6 2462.5 2336.2 2257.5 1606.8 1754.7 True False 2308.560410588158 1869.405531693934 1977.042905436599 1858.9780859072594 2137.0790948555727 2437.729485771107 2159.978553114588 2197.6237666065476 2726.622243971232 1979.9328372253913 1.1659791520116884 0.9441762349442386 0.9985403889796373 0.9389096695382689 1.0793694890430732 1.231218271619383 1.0909352643201304 1.1099486433520749 1.3771286544205332 1.0 10.95123577706532 -6.532479913846884 6.824049646524484 1.1637875813934544 1.006220782529113 0.29582011912242134 0.10912127942227877 0.17139681038830426 40.156309159802596 0.03441918554966971 0.03551891971161021 2.9344052172840566e-07 6.532479913846884 -0.15756679886434144 SDS(ph)DSSTLAK ddPTM_A459_Selumetinib_30min_R2 1 SDSDSSTLAK 10 0 Q6AWC2-3;Q6AWC2-2;Q6AWC2-4;Q6AWC2;Q6AWC2-6;Q6AWC2-7 Q6AWC2-3 WWC2 Protein WWC2 1 S(0.12)DS(0.863)DS(0.013)S(0.003)T(0.001)LAK 109.39 0.010099 19868000.0 88022.0 74000.0 78325.0 76551.0 77025.0 62115.0 96309.0 102780.0 76075.0 123110.0 True False 83130.08961998421 79675.56205249738 73285.65477381187 66124.62174215935 67348.43088776324 70670.7774261707 100787.55933266298 103079.0727838549 91292.12571309954 119555.49442180582 0.6953263839693682 0.6664316218825764 0.6129844147124804 0.5530872676488118 0.5633235947329202 0.5911127528512901 0.8430190500243563 0.8621859938965234 0.7635962375013079 1.0 16.86732090806597 -7.273728670903714 9.729471332762358 0.8558962714051724 0.6109989667647582 0.7707727597369806 0.06760113453831411 0.14831917392517294 109.54351379546617 0.028185507641004984 0.01967870890351034 5.324408022041808e-08 7.273728670903714 -0.24489730464041426 SDS(ph)DSSTLPR ddPTM_A459_Selumetinib_30min_R2 2 SDSDSSTLPR 10 0 Q9ULE0 Q9ULE0 WWC3 Protein WWC3 1 S(0.002)DS(0.99)DS(0.006)S(0.002)TLPR;S(0.005)DS(0.91)DS(0.079)S(0.005)T(0.001)LPR 141.71 0.0012789 89875000.0 229487.0 155995.0 193846.0 212431.0 189131.0 166251.0 148025.0 157342.0 118371.0 188482.0 True False 216733.03124924813 167959.3148970177 181374.1594035667 183497.53133608497 165370.67292740723 189150.56617368272 154908.4558059731 157799.83917062977 142048.50756208098 183040.0349249522 1.1840744640270109 0.9176097183650685 0.990898846134571 1.0024994335874136 0.9034672277854976 1.0333835778125582 0.846309146900495 0.8621056002055993 0.7760515759315821 1.0 17.481799706939192 -1.5228787452803376 0.429378285710138 0.8890014907576888 5.510624513011452 0.4388198940902276 0.08226526196684418 81.30113543911237 1.0230780457818156 0.05480041347301132 324.90611869754287 0.029999999999999995 1.5228787452803376 4.621623022253763 SDS(ph)DSSTLSK ddPTM_A459_Selumetinib_30min_R1 2 SDSDSSTLSK 10 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.136)DS(0.672)DS(0.107)S(0.025)T(0.06)LS(0.001)K;S(0.001)DS(0.99)DS(0.007)S(0.001)T(0.001)LSK 132.17 0.0024854 59731000.0 6937.299999999999 8625.9 7616.400000000001 7292.5 7937.4 8212.7 7116.0 7304.3 5204.0 5505.5 True False 7098.925592364014 7615.975617927886 6582.1347138905 6019.001772178972 7219.46357146179 8130.087694534975 6579.234390875532 7110.5662362897865 8830.807914878207 6212.1845531112995 1.1427422240391427 1.2259738185198497 1.0595523454939721 0.9689026011251429 1.1621457008784464 1.3087324796980018 1.0590854689885862 1.144616064686704 1.4215301943106955 1.0 12.60088497496416 -6.510832655696007 24.787494175933062 1.1931373510627519 1.1005054635384337 0.0961675313786926 0.12636237834885575 1266.359589770512 2605821.746282868 0.04038804712796851 0.04349294136097996 3.084376207021504e-07 6.510832655696007 -0.09263188752431817 SDS(ph)DSSTLSK ddPTM_A459_Selumetinib_30min_R2 2 SDSDSSTLSK 10 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.002)DS(0.851)DS(0.141)S(0.003)T(0.003)LSK;S(0.001)DS(0.682)DS(0.309)S(0.003)T(0.005)LSK 112.94 0.0079334 70007000.0 42034.0 46043.0 42623.0 43591.0 49920.0 41089.0 64084.0 92739.0 48511.0 67274.0 True False 39697.9185554341 49574.35004842068 39880.68258441354 37653.830601330716 43648.60330953768 46748.63678119502 67064.03298003701 93008.85513623215 58214.55551059041 65331.624821156474 0.6076370925123332 0.7588109156037234 0.6104345742752582 0.5763492137905194 0.6681083384811648 0.7155590712640031 1.0265171448532462 1.4236421547886084 0.8910624168609178 1.0 15.995493900082552 -7.281120279750845 3.357505996067186 1.1342353111128871 0.6496993837003011 0.7063752310368723 0.13600621965388218 0.12310704699040578 2.915929703270489 0.05706400141255236 0.03879393587374023 5.234554432404634e-08 7.281120279750845 -0.484535927412586 SDS(ph)DTEGLLFSR ddPTM_A459_Selumetinib_30min_R1 2 SDSDTEGLLFSR 12 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.34)DS(0.654)DT(0.006)EGLLFSR;S(0.005)DS(0.991)DT(0.004)EGLLFSR 185.2 0.00010451 7985000.0 1866.19 1847.34 1447.6 1569.91 1735.5900000000001 1592.56 2316.16 1896.52 900.25 1743.68 True False 1909.66859602638 1631.0525739949346 1251.023871097617 1295.7546893605054 1578.6061909433017 1576.5402923287854 2141.450186448886 1846.2181288348395 1527.6584983414868 1967.4983128815022 0.9706074884656813 0.8289982071731358 0.6358449523981693 0.6585798223444502 0.8023418269829934 0.8012918140803187 1.0884127180330958 0.9383581763437236 0.7764471706733779 1.0 10.942146683292671 -7.069238304137996 9.657424878956844 0.9458871895973561 0.770756976021567 0.3470466430745266 0.11274987268333043 0.6265062054923544 84.53428717342926 0.04573538309329021 0.035455295947962866 8.526321331203583e-08 7.069238304137996 -0.17513021357578906 SDS(ph)DTEGLLFSR ddPTM_A459_Selumetinib_30min_R2 3 SDSDTEGLLFSR 12 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.005)DS(0.939)DT(0.056)EGLLFSR;S(0.041)DS(0.957)DT(0.001)EGLLFSR;S(0.122)DS(0.86)DT(0.018)EGLLFSR 163.33 0.00049983 6544400.0 26900.9 19756.800000000003 24645.6 25881.1 24060.899999999998 23293.9 28142.2 31382.7 23790.6 24333.0 True False 25405.855670834964 21272.08303187538 23059.928928100366 22356.049532612247 21038.154634824816 26502.423284029264 29450.868062711397 31474.018461314332 28549.384764903887 23630.44306527336 1.0751324298345764 0.9001982304401325 0.9758568159049287 0.9460698418078362 0.890298780124944 1.1215372987642573 1.2463104471363708 1.331926717344021 1.2081612133146697 1.0 14.52835905930895 -6.950558515455497 4.147804954805897 1.220984213191501 0.9555381748566376 0.5997672693520071 0.09204995850410912 0.13017903154855748 4.74642942339587 0.032907949041623454 0.028171218639569475 1.1205764330645562e-07 6.950558515455497 -0.26544603833486335 SDS(ph)DYDLSPK ddPTM_A459_Selumetinib_30min_R1 4 SDSDYDLSPK 10 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9;Q07343-3;Q07343;E9PMG3 A0A1B0GW84;Q08499-6;Q08499-9;Q07343-3 PDE4D;PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4D;cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 SDS(1)DYDLSPK;S(0.308)DS(0.692)DYDLSPK;S(0.02)DS(0.98)DYDLSPK;S(0.204)DS(0.796)DYDLSPK 208.33 0.00017119 53069700.0 16503.1 17814.699999999997 18393.8 18826.0 16113.2 14997.9 16799.899999999998 17237.8 8736.8 15251.5 True False 16887.590120557365 15728.946642170658 15896.022989911135 15538.39250778762 14655.76390501652 14847.034743003658 15532.670017322904 16780.597547734356 14825.711489375073 17209.178587190447 0.9813129682509975 0.9139859036548328 0.9236944639381712 0.9029130837978248 0.8516248367557446 0.8627393032027085 0.9025805583123274 0.9750957875598373 0.8615002403665278 1.0 14.070890617167645 -10.116932443113411 7.165127185302086 0.9999999999976188 0.9076169227864016 0.3000891579552474 0.041960588006339686 0.0 0.0 0.04187071108838815 0.01015513908453794 7.639546116615779e-11 10.116932443113411 -0.09238307721121719 SDS(ph)DYDLSPK ddPTM_A459_Selumetinib_30min_R2 4 SDSDYDLSPK 10 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9;Q07343-3;Q07343;E9PMG3 A0A1B0GW84;Q08499-6;Q08499-9;Q07343-3 PDE4D;PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4D;cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 SDS(1)DYDLSPK;S(0.078)DS(0.922)DYDLSPK;S(0.002)DS(0.998)DYDLSPK;S(0.196)DS(0.804)DYDLSPK 188.27 0.00018531 90481000.0 762360.0 719160.0 752420.0 740310.0 663380.0 564500.0 580200.0 588610.0 467787.0 682780.0 True False 719991.0831688814 774317.2595361321 704010.1163729553 639478.5008940169 580040.273707554 642254.7509792056 607180.4496444896 590322.7576503685 561357.4710608438 663066.367324511 1.0858507061277485 1.1677824388236144 1.061749096419493 0.9644260852414039 0.8747846404094218 0.9686130719775746 0.9157159517748992 0.8902921136421611 0.8466082713951167 1.0 19.338793753549965 -5.732189300571629 2.4002150511710725 0.9132065055580026 1.1264657353085927 0.7765005077134949 0.046056089087064905 0.12119118133086555 1.4213687439052416 0.013226629969190332 0.02511676106917562 1.852723880853384e-06 5.732189300571629 0.21325922975059008 SDS(ph)FENPVLQQHFR ddPTM_A459_Selumetinib_30min_R1 2 SDSFENPVLQQHFR 14 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 S(0.111)DS(0.889)FENPVLQQHFR;S(0.265)DS(0.735)FENPVLQQHFR 239.86 1.0922e-19 57606000.0 5471.8 10729.0 8401.400000000001 13254.1 6276.6 9679.4 6033.6 3638.2 1962.74 4210.4 True False 5599.282293730618 9472.843692223218 7260.536025586851 10939.5202452708 5708.882638223733 9582.034024192024 5578.480694320774 3541.7031174608787 3330.626427142206 4750.845852769012 1.1785863964555068 1.9939278153388218 1.528261756031313 2.3026468515905947 1.2016560450801268 2.0169111609056256 1.1742078920681838 0.7454889565395204 0.7010596702902839 1.0 12.21396868209628 -7.494632887325457 3.9812968826290627 0.8056437175994512 1.711802698650995 0.5824691454070997 0.3405932477854659 0.1444396835456172 5.061801357564898 0.15000692764439405 0.09100984597387818 3.201600305069316e-08 7.494632887325457 0.9061589810515439 SDS(ph)FENPVLQQHFR ddPTM_A459_Selumetinib_30min_R2 4 SDSFENPVLQQHFR 14 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 S(0.128)DS(0.872)FENPVLQQHFR;S(0.009)DS(0.991)FENPVLQQHFR;S(0.405)DS(0.595)FENPVLQQHFR;S(0.161)DS(0.839)FENPVLQQHFR 191.63 8.1354e-05 49127600.0 149455.0 206798.0 204569.0 125994.0 140732.0 53767.0 111838.4 93658.3 88135.1 121086.7 True False 141148.88941576815 222658.74163962624 191407.25325788627 108833.39984822703 123051.98799995717 61172.9162017696 117039.1072035855 93930.83014703375 105764.58270044798 117590.6123499706 1.2003414779037287 1.8935077995593235 1.6277426355109386 0.9255279624220295 1.046443976613818 0.5202193863886694 0.9953099559959453 0.7987953142677654 0.8994304952309777 1.0 16.843413364060574 -5.780272524251969 5.972820900230727 0.8682784197929566 1.6090261713024965 0.6926366852179446 0.21028952228377204 0.08104495934791997 9.56307671140856 0.05701151198075853 0.08960797328708386 1.6585458262712145e-06 5.780272524251969 0.7407477515095399 SDS(ph)GGSSSEPFDR ddPTM_A459_Selumetinib_30min_R1 1 SDSGGSSSEPFDR 13 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 S(0.308)DS(0.682)GGS(0.006)S(0.001)S(0.001)EPFDR 101.45 0.010104 13886000.0 1789.2 1896.4 1940.6 1913.7 1791.9 1512.1 1792.5 1654.8 753.7 1589.1 True False 1830.884878822841 1674.368606387559 1677.0771789527746 1579.508219598066 1629.82296138564 1496.8896468769515 1657.290281849971 1610.9093284520538 1278.9738519299963 1793.0764641447931 1.021085779348557 0.9337965445807959 0.9353071173976151 0.8808928404240762 0.9089534071615752 0.8348164045479746 0.9242719510238036 0.8984052608266074 0.7132846130686358 1.0 10.808221296622047 -1.9272923110954092 0.5388462974309375 0.8709496911088591 4.6535863046724755 0.2756832045187957 0.06963214486286032 101.03989077295985 1.5222974251010641 0.03378294745568268 425.51896051542565 0.011822455524736116 1.9272923110954092 3.7826366135636165 SDS(ph)LILDHQWELEK ddPTM_A459_Selumetinib_30min_R1 3 SDSLILDHQWELEK 14 0 A0A3B3ITK3;A0A3F2YNW9;A0A3B3IUA1;A0A3B3IU40;A0A3B3IT28;A0A3B3ITE5;A0A3B3ITF7;A0A3B3ITW6;Q12756;Q12756-3;Q12756-2;H7C3Y8 A0A3B3ITK3 KIF1A Kinesin-like protein KIF1A 1 S(0.142)DS(0.858)LILDHQWELEK;S(0.153)DS(0.847)LILDHQWELEK;S(0.163)DS(0.837)LILDHQWELEK 136.39 0.00039392 9762000.0 5339.5 5922.099999999999 5573.9 6324.3 5420.099999999999 5451.6 5494.700000000001 5276.799999999999 3206.22 4445.2 True False 5463.899961141607 5228.737778890402 4816.994995241093 5219.87972681405 4929.852911996376 5396.761853656762 5080.230355191653 5136.84212253795 5440.7211669563385 5015.784719914693 1.0893410037013183 1.0424565787543074 0.9603671736778646 1.0406905436130498 0.9828677240518053 1.0759556390507423 1.012848564855881 1.0241352867762865 1.084719833639286 1.0 12.292259712910376 -6.765895571056178 24.999690920101514 1.0393726022603267 1.021704634556758 0.03847158720107724 0.04064107673543724 445.2758950917832 2498029.3992175376 0.014093451641063275 0.012838518181343102 1.7143694892879087e-07 6.765895571056178 -0.01766796770356871 SDS(ph)LLSFR ddPTM_A459_Selumetinib_30min_R1 3 SDSLLSFR 8 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.012)DS(0.988)LLSFR;S(0.147)DS(0.853)LLSFR;S(0.17)DS(0.83)LLSFR 171.33 0.00016329 26047800.0 6950.400000000001 8466.9 8353.9 7894.0 8056.9 7850.6 8177.700000000001 7688.2 4125.900000000001 7279.4 True False 7112.33079687586 7475.5914118449755 7219.486264688029 6515.461088732369 7328.154817561226 7771.630091774484 7560.849505095962 7484.283961206844 7001.350956186775 8213.781897360532 0.8659020760170636 0.9101278199567521 0.87894788964484 0.7932352197988223 0.8921779162307806 0.9461695220166326 0.9205077027338178 0.9111861082666306 0.8523906580033046 1.0 13.003830924239356 -6.522499132446648 24.99992753041767 0.9200446311420324 0.8636954917173336 0.3188773227344023 0.0436912285912077 19.10546513681582 1258350.4994757771 0.014414513324778173 0.014570771725140904 3.0026234189421044e-07 6.522499132446648 -0.05634913942469877 SDS(ph)LLSFR ddPTM_A459_Selumetinib_30min_R2 2 SDSLLSFR 8 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.19)DS(0.81)LLSFR;S(0.357)DS(0.643)LLSFR 163.38 0.00033749 11582500.0 26396.0 26681.0 27690.0 29794.0 33480.0 26514.0 30630.0 27277.0 26007.0 27082.0 True False 24929.015991560107 28727.346907063227 25908.455546592482 25736.005802483247 29273.94308500245 30166.06282987186 32054.355692193552 27356.371554049547 31209.12669629412 26300.072292513592 0.9478687250094077 1.0922915567513694 0.985109670362671 0.978552663895494 1.1130746242600777 1.1469954338664967 1.2187934442034951 1.0401633596207502 1.186655547908053 1.0 14.682779144690887 -6.323799699854754 5.963869379159967 1.1270216153797785 1.0064757266926811 0.39952137381650654 0.0694372725687369 0.21798836578978562 15.783594783863416 0.02073805493178273 0.023692550755839065 4.7446075996521313e-07 6.323799699854754 -0.12054588868709737 SDS(ph)PEIPFQAAAGPSDGLDASSPGNSFVGLR ddPTM_A459_Selumetinib_30min_R1 2 SDSPEIPFQAAAGPSDGLDASSPGNSFVGLR 31 0 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 S(0.189)DS(0.811)PEIPFQAAAGPSDGLDASSPGNSFVGLR;S(0.226)DS(0.774)PEIPFQAAAGPSDGLDASSPGNSFVGLR 151.4 2.6464e-20 30122000.0 8429.900000000001 9279.3 7791.6 9201.599999999999 8057.5 7455.5 8306.3 7965.9 4963.5 7539.1 True False 8626.300268269997 8192.875242170465 6733.543516195217 7594.713295424338 7328.700547667161 7380.504439052381 7679.749103559501 7754.618455110115 8422.696980303219 8506.816922052743 1.0140455998186007 0.9630952819651698 0.7915467768842467 0.8927796806977351 0.8615091419998144 0.8675988335800958 0.9027758765621036 0.9115769771660822 0.9901114667777257 1.0 13.054403690390236 -8.237245827682111 2.801156662368295 1.001730442390343 0.8947778234672098 0.3128409316679601 0.05609416909842034 0.339659477795768 4.914863395562199 0.05357779887126494 0.015668585873803174 5.791008099034947e-09 8.237245827682111 -0.10695261892313324 SDS(ph)PEIPFQAAAGPSDGLDASSPGNSFVGLR ddPTM_A459_Selumetinib_30min_R2 1 SDSPEIPFQAAAGPSDGLDASSPGNSFVGLR 31 0 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 S(0.24)DS(0.759)PEIPFQAAAGPS(0.001)DGLDASSPGNSFVGLR 55.49 0.0023211 3165500.0 7127.9 7506.5 7367.8 8680.4 9333.2 7002.9 9130.7 8304.7 7821.7 7822.8 True False 6731.7598532444845 8082.224412798244 6893.763769454101 7498.114545474778 8160.679976133353 7967.4859090031505 9555.295642138812 8328.865302082904 9386.258556557996 7596.935437924652 0.8861151852941745 1.0638795707609914 0.9074400889389886 0.9869920057558275 1.0742068354819014 1.0487763090928315 1.2577829205231668 1.0963454106118087 1.2355322265476767 1.0 12.891201845305366 -6.588246307426553 1.4857663814243673 1.1513213035324719 0.9616106553215775 0.4737811021951188 0.08392514811283427 0.3240151817598752 1.4759027722781919 0.0330448052967517 0.03460992862162085 2.580796092971295e-07 6.588246307426553 -0.18971064821089434 SDS(ph)PENKYSDSTGHSK ddPTM_A459_Selumetinib_30min_R2 1 SDSPENKYSDSTGHSK 16 1 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2;A0A494C0S5;E9PMZ7;C9JMU2;A0A494C0B7;A0A494C0C1;C9JVK6;C9JD58;J3QTA0;Q9BTA9-3 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 S(0.021)DS(0.879)PENKY(0.007)S(0.009)DS(0.041)T(0.041)GHS(0.003)K 58.658 0.043738 6898400.0 16452.0 18441.0 26334.0 28189.0 31085.0 16558.0 11381.0 15541.0 11480.0 27079.0 True False 15537.663702574146 19855.36540283922 24639.6991102913 24349.609571262667 27179.82439657411 18838.714201441413 11910.239051023666 15586.221737048954 13776.320778000401 26297.158910308546 0.5908495193556192 0.7550384233734037 0.9369719061412556 0.9259406939856748 1.0335650512390355 0.7163783078504573 0.45290972654672684 0.5926960319253013 0.5238710700645328 1.0 14.682619321750872 -6.996169130815498 24.630816447805806 0.6050295970462964 0.8547495897288279 0.2256036099407378 0.17586077257213334 116.01413555892994 745911.2774803563 0.061926352852897895 0.054364907324542966 1.0088599210785665e-07 6.996169130815498 0.24971999268253142 SDS(ph)PSVGETER ddPTM_A459_Selumetinib_30min_R2 1 SDSPSVGETER 11 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 S(0.013)DS(0.942)PS(0.045)VGETER 158.34 0.00057195 8950500.0 37127.0 31948.0 38463.0 38207.0 41016.0 32593.0 25814.0 41268.0 28104.0 28611.0 True False 35063.629971156704 34398.30887098895 35988.33245534802 33003.14068924876 35863.20339230767 37082.38990020417 27014.40214947061 41388.08304771482 33725.58529136966 27784.926089694512 1.261965925623314 1.2380205281074097 1.2952466506180906 1.1878073953736263 1.2907431632725992 1.3346225856601472 0.9722682746127695 1.4895876603776803 1.2138087098917476 1.0 14.762014782149421 -11.172712483580828 3.0940222179692705 0.9789797462922123 1.2547208512876762 0.2777026720682725 0.12277976880532031 86556452.74507922 107780800.64060354 14779093.16553518 0.02886029748406299 6.718735068259315e-12 11.172712483580828 0.2757411049954639 SDS(ph)PVPTAPTSGGPK ddPTM_A459_Selumetinib_30min_R2 1 SDSPVPTAPTSGGPK 15 0 B4E349;F5H6D8;B4DTN4;Q86U44 B4E349 METTL3 N6-adenosine-methyltransferase 70 kDa subunit 1 S(0.207)DS(0.793)PVPTAPTSGGPK 202.01 1.3998e-05 12957000.0 55561.0 42232.0 50237.0 52155.0 47480.0 40441.0 52806.0 60055.0 47272.0 34633.0 True False 52473.142048305504 45471.05860271704 47004.80611390995 45051.39902760667 41515.13792341446 46011.38066315333 55261.58363310393 60229.75010735952 56727.72089003795 33633.05530265945 1.5601657826238677 1.3519752574819313 1.3975776417253762 1.3394976644909313 1.2343552362348644 1.368040466413264 1.64307355177257 1.7907903271159846 1.686665703711799 1.0 15.037592222041026 -7.253457355840786 23.108101068101867 1.5960315904254045 1.3671927852728623 0.07955870914082164 0.2145737789795043 336.3373845119154 973705.5270448428 0.07935911238264579 0.060201906378581777 5.5788237892977803e-08 7.253457355840786 -0.2288388051525423 SDS(ph)RAQAVSEDAGGNEGR ddPTM_A459_Selumetinib_30min_R1 2 SDSRAQAVSEDAGGNEGR 18 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 S(0.001)DS(0.999)RAQAVSEDAGGNEGR;S(0.312)DS(0.688)RAQAVSEDAGGNEGR 159.72 7.039e-05 46793000.0 1180.79 2166.59 8614.4 11112.3 4505.39 4403.63 2707.8199999999997 1811.97 1562.49 1080.6399999999999 True False 1208.30010958262 1912.9246355796365 7444.611795512101 9171.745408705427 4097.878269991209 4359.333480376129 2503.566957321612 1763.9106694919444 2651.4314102455896 1219.3506703249827 0.9909373398389018 1.5688059900519034 6.105390333305803 7.521827503699951 3.3607053079316698 3.575126980669371 2.053196851611488 1.4465983514175007 2.174461764587317 1.0 10.25189737172362 -7.231164175986956 2.1647092913223442 1.5928919126076628 4.083282617342498 0.2605982569507278 1.8164296825716977 0.5076653293382456 4.655387978266183 0.9918879614299376 0.6573189889417029 5.872673063840732e-08 7.231164175986956 2.4903907047348346 SDS(ph)RAQAVSEDAGGNEGR ddPTM_A459_Selumetinib_30min_R2 1 SDSRAQAVSEDAGGNEGR 18 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 S(0.009)DS(0.991)RAQAVSEDAGGNEGR 154.48 0.00040185 0.0 4256.0 14388.0 10582.0 10622.0 8738.8 4481.7 717.63 2367.4 1200.5 10760.0 True False 4019.468558117889 15491.513335288239 9901.16564081046 9175.265276027963 7640.953818136773 5099.013494178044 751.0012169568685 2374.288742055833 1440.6335447726042 10449.33084216256 0.3846627711221011 1.4825364005875579 0.9475406406752594 0.8780720425662281 0.7312385772403609 0.4879751221584222 0.0718707473522241 0.22721921412189278 0.13786849766108614 1.0 13.35112293701312 -6.662551721781651 1.8736437660493444 0.29422371962443666 0.9688894891486781 0.34650234150015446 0.3460441825416737 0.3181410215835203 2.2954908749887486 0.13079173509765135 0.1285961809122045 2.174944996123123e-07 6.662551721781651 0.6746657695242415 SDS(ph)SLETMENTGVMDK ddPTM_A459_Selumetinib_30min_R2 1 SDSSLETMENTGVMDK 16 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 S(0.428)DS(0.453)S(0.111)LET(0.007)MENTGVMDK 90.697 0.012163 2659000.0 9390.9 8630.8 8924.5 11249.0 10431.0 9027.3 10267.0 9801.1 8117.7 9343.7 True False 8868.991372751241 9292.754607603954 8350.307386260905 9716.866794392632 9120.564525676835 10270.728633329636 10744.435843674548 9829.619578340546 9741.466827489017 9073.92310315189 0.9774153110985188 1.0241165262218337 0.9202532676698977 1.0708561979126108 1.0051401606553998 1.131895048764743 1.1841003854156966 1.0832822216584752 1.0735672670738472 1.0 13.147510718301428 -6.38308072394641 1.7105711275853004 1.1023872908148296 0.9862638455348922 0.38019632021000227 0.05784558903133573 0.3508860311601365 2.0429897254122458 0.021243852706659152 0.0258213778450551 4.139227302965385e-07 6.38308072394641 -0.11612344527993734 SDS(ph)VSASER ddPTM_A459_Selumetinib_30min_R2 1 SDSVSASER 9 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 S(0.078)DS(0.92)VS(0.002)ASER 172.21 0.00051016 43488000.0 91205.0 84234.0 110570.0 100450.0 115970.0 60530.0 93063.0 117930.0 77219.0 116150.0 True False 86136.19122254278 90694.4769450008 103456.04657951341 86768.53671408488 101400.81181504586 68867.45806336812 97390.61390083602 118273.15677563741 92664.95767913002 112796.44770605778 0.7636427651251007 0.8040543721850739 0.9171924177002009 0.7692488414191873 0.89897167754158 0.6105463377963237 0.8634191579741178 1.0485539144269125 0.8215237231637873 1.0 16.783362108152666 -7.528219606003361 24.973417076415856 0.9522206434611977 0.79810008540752 0.3701109755948684 0.0949917236746567 159.7318807584782 746876.7215380451 0.04289099108728754 0.02486477486507016 2.9633325673882623e-08 7.528219606003361 -0.15412055805367775 SDS(ph)YSQSLK ddPTM_A459_Selumetinib_30min_R1 3 SDSYSQSLK 9 0 Q9H8W4 Q9H8W4 PLEKHF2 Pleckstrin homology domain-containing family F member 2 1 S(0.179)DS(0.795)YS(0.025)QSLK;SDS(0.954)YS(0.045)QS(0.001)LK;S(0.049)DS(0.95)YS(0.001)QSLK 139.31 0.0023913 45274800.0 7115.8 7716.099999999999 7690.6 8981.5 6978.7 7642.7 8076.9 7244.6 3718.2999999999997 6355.6 True False 7281.58429506348 6812.69542488243 6646.2587614419335 7413.049628635638 6347.477817189558 7565.8213770163875 7467.6529302505005 7052.449674222718 6309.683526112918 7171.403168786519 1.015363956492716 0.9499808147078718 0.9267724328161785 1.033695840850349 0.8851096037686055 1.0549987497490827 1.0413098740220612 0.983412800568577 0.8798394648310627 1.0 12.808039711342905 -6.783948210767864 24.999959484282048 0.9939627807481414 0.9635119724775698 0.05952794861711508 0.058679856264437724 802.6431293909327 891468.5071333499 0.020911970913859844 0.01845696991360357 1.6445678247780732e-07 6.783948210767864 -0.03045080827057156 SDS(ph)YSQSLK ddPTM_A459_Selumetinib_30min_R2 2 SDSYSQSLK 9 0 Q9H8W4 Q9H8W4 PLEKHF2 Pleckstrin homology domain-containing family F member 2 1 S(0.062)DS(0.921)YS(0.016)QSLK;S(0.056)DS(0.944)YSQSLK 120.86 0.006446899999999999 23290000.0 83572.0 77945.0 82466.0 72979.0 74472.0 72707.0 67506.0 65147.0 54862.0 75013.0 True False 78927.40280522282 83923.13086732283 77160.22734219187 63039.13430420304 65116.16157187273 82721.72928156787 70645.16276060132 65336.566984333556 65835.93297235701 72847.17978281963 1.0834654552246257 1.1520436496996054 1.0592067884059588 0.8653613563646876 0.8938734727412166 1.1355515687523852 0.9697721033431463 0.8968990588121932 0.9037540391904622 1.0 16.15258550019754 -5.561356326189557 7.082346349611136 0.9540060142496571 1.1150771801150263 0.4610539908928398 0.07414346035746526 0.1724988070105001 24.36147914553776 0.02149990727029254 0.03783670920701909 2.7456405092671672e-06 5.561356326189557 0.16107116586536918 SDSDS(ph)STLSK ddPTM_A459_Selumetinib_30min_R2 1 SDSDSSTLSK 10 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.04)DS(0.365)DS(0.586)S(0.003)T(0.007)LSK 124.6 0.0037912 54166000.0 88658.0 78149.0 72381.0 89886.0 99321.0 79997.0 129570.0 223020.0 102640.0 161210.0 True False 83730.74328609397 84142.77701135963 67724.08526247405 77643.37173800141 86843.40803899415 91015.86060953677 135595.26173808426 223668.95127705144 123170.8680012164 156555.44842611768 0.5348312315403608 0.5374631024168326 0.4325884914470715 0.4959480651651878 0.5547134188688275 0.5813650149166758 0.8661165299658986 1.428688388207749 0.7867555504422046 1.0 17.256314192306945 -7.364152194535829 3.1184028939043698 1.0893233078398057 0.5153040262474943 0.7234608832975301 0.1536190557111883 0.12357200854667902 2.298242259247908 0.0669248052155203 0.0425853248536364 4.3236228706716894e-08 7.364152194535829 -0.5740192815923114 SDSDSST(ph)LSK ddPTM_A459_Selumetinib_30min_R2 1 SDSDSSTLSK 10 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.001)DS(0.164)DS(0.249)S(0.12)T(0.268)LS(0.198)K 111.86 0.020098 13579000.0 47230.0 42084.0 42147.0 42611.0 48192.0 35641.0 66685.0 108530.0 60279.0 89434.0 True False 44605.145676670116 45311.707478612094 39435.3079061839 36807.308291925016 42137.69011805369 40550.22423321501 69785.98463382071 108845.80433189136 72336.48433598304 86851.80804256191 0.513577629320178 0.5217128865804037 0.4540528147307946 0.42379438173454625 0.4851676789204437 0.46688981089885073 0.8035064117447267 1.2532359059071199 0.8328725212091658 1.0 16.4062682621856 -7.432691364327235 3.4962622083093806 1.0343954325043598 0.4769596112962733 0.8586690996731172 0.10103203851267677 0.07820562980733356 1.7976781421455648 0.04407358074859212 0.027440556353738117 3.6923990934902084e-08 7.432691364327235 -0.5574358212080865 SDSDYDLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SDSDYDLSPK 10 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9;Q07343-3;Q07343;E9PMG3 A0A1B0GW84;Q08499-6;Q08499-9;Q07343-3 PDE4D;PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4D;cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 SDS(0.021)DYDLS(0.979)PK;SDSDYDLS(1)PK 137.4 0.0017507999999999998 139885000.0 8572.0 9169.0 10568.099999999999 9643.2 6374.5 7417.9 7342.4 7666.1 5546.1 8176.8 True False 8771.710921791531 8095.489217447547 9133.010066418025 7959.196145282994 5797.92760050938 7343.282660914311 6788.556856599845 7462.770124997765 9411.326628882789 9226.371928776767 0.9507215826009395 0.8774293167391147 0.9898809778015181 0.8626571968618031 0.6284081809476837 0.7959014353205122 0.7357774983497627 0.808852079951559 1.0200463087260936 1.0 13.17154773542101 -5.995350320860614 23.997025531765885 0.8090251396627699 0.9320053211047555 0.13767309643261672 0.11217830704391099 132.71352491506724 684913.1161037937 0.03167351089235552 0.04675358791944598 1.0107637991916075e-06 5.995350320860614 0.12298018144198564 SDSDYDLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 SDSDYDLSPK 10 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9;Q07343-3;Q07343;E9PMG3 A0A1B0GW84;Q08499-6;Q08499-9;Q07343-3 PDE4D;PDE4B cAMP-specific 3,5-cyclic phosphodiesterase 4D;cAMP-specific 3,5-cyclic phosphodiesterase 4B 1 SDSDYDLS(1)PK;SDSDYDLS(1)PK;SDS(0.001)DYDLS(0.999)PK 144.28 0.00099767 170254000.0 987510.0 813287.0 819075.0 779639.0 669715.0 550241.0 740271.0 676888.0 460320.0 607697.0 True False 932628.1475157412 875663.4977701242 766376.6062414299 673450.8232477094 585579.414371936 626031.7031595199 774695.0683191585 678857.63201516 552396.8624154322 590151.2086235733 1.580320660006673 1.4837951443198083 1.2986105849530871 1.1411496128567087 0.9922531815832416 1.0607988156452848 1.312706060750095 1.1503113474908901 0.9360259783315591 1.0 19.170725123796096 -5.418535223762578 1.6859266085170133 1.0915925115744973 1.5754836270170152 0.7701680576992737 0.0988983382355553 0.21289202596229562 1.1118349862288421 0.031543590182594866 0.10963441642406284 3.8147385331675075e-06 5.418535223762578 0.48389111544251784 SDSFENPVLQQHFR ddPTM_A459_Selumetinib_30min_R2 2 SDSFENPVLQQHFR 14 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 ; 184.11 0.00010719 13128600.0 171123.0 163339.0 189314.0 192484.0 199682.0 150903.0 160163.0 159078.0 130162.0 178281.0 False True 161612.6687196446 175866.576082336 177133.74334949814 166267.34714657968 174596.16198027073 171688.51848895472 167610.89685696363 159540.89064321938 156198.0370301472 173133.56430033283 0.9334566025527953 1.0157855687488893 1.023104584401822 0.9603415017677196 1.0084477997426353 0.9916535778766075 0.9681016938241445 0.9214902453372104 0.9021822987436003 1.0 17.401525912345313 -7.553208088220978 3.755181258812164 0.9342669696531508 0.9907664929666768 0.2699165383133064 0.03427175933906609 0.25048655356045346 7.640139838639142 0.016517110020698826 0.009374197105399298 2.7976405346239774e-08 7.553208088220978 0.056499523313526034 SDSGGS(ph)SSEPFDR ddPTM_A459_Selumetinib_30min_R2 1 SDSGGSSSEPFDR 13 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 S(0.005)DS(0.202)GGS(0.611)S(0.091)S(0.091)EPFDR 94.547 0.015722 22584000.0 15707.0 13698.0 14814.0 17792.0 16937.0 13335.0 14657.0 12913.0 15621.0 12555.0 True False 14834.067820102842 14748.59255398793 13860.883368263663 15368.698907088063 14809.222641298873 15171.775206922423 15338.57954229452 12950.574692137772 18745.636487207696 12192.504528192469 1.2166546902486148 1.2096442137778234 1.1368364339101484 1.2605038506691835 1.2146169482287927 1.2443526407426013 1.2580335325549765 1.0621750980032392 1.5374721775876776 1.0 13.573706887727996 -5.783432756568026 24.902154984316446 1.2296100275214592 1.189904943569181 0.015308881124962315 0.134781397295977 1222.134907182827 1383765.3121578437 0.035371641566091155 0.052514051499187885 1.6465208835530465e-06 5.783432756568026 -0.03970508395227812 SDSGST(ph)S(ph)GGS(ph)KS(ph)QSRSR ddPTM_A459_Selumetinib_30min_R2 1 SDSGSTSGGSKSQSRSR 17 2 Q96S94;Q96S94-3;A0A0A0MSF3 Q96S94 CCNL2 Cyclin-L2 4 S(0.018)DS(0.024)GS(0.441)T(0.518)S(0.999)GGS(0.996)KS(0.475)QS(0.344)RS(0.185)R 62.002 0.047562 16364000.0 3636.7 2973.2 10027.0 11711.0 13816.0 10600.0 4790.2 7215.8 8333.5 9874.8 True False 3434.5867728635667 3201.2348796551973 9381.873736572148 10115.94159739818 12080.310563392883 12060.053782780476 5012.95379160123 7236.796783360008 10000.432857444808 9589.688866188364 0.3581541404302849 0.33382051538107926 0.978329314692478 1.0548769348571145 1.2597187178810392 1.257606367741732 0.5227441538042037 0.7546435431159545 1.042831837089591 1.0 13.22726829297236 -5.2623030262518915 23.131522175494087 0.9807801202123703 0.3459871968363521 0.604765543183569 0.2062489872236556 18.653356687330056 499667.0101449784 0.059724535279648265 0.13729521186754212 5.4663441906082654e-06 5.2623030262518915 -0.6347929233760181 SDSKEDENLVINEVINS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SDSKEDENLVINEVINSPK 19 1 Q5FWF5-2;Q5FWF5 Q5FWF5-2 ESCO1 N-acetyltransferase ESCO1 1 SDSKEDENLVINEVINS(1)PK 69.133 0.0099363 2123400.0 22000.0 29158.0 23282.0 21754.0 17805.0 12689.0 18614.0 19964.0 14493.0 15495.0 True False 20777.32807297781 31394.324842252885 21784.06146752494 18791.06767225686 15568.176721280422 14436.794570726554 19479.587882941258 20022.09193478189 17392.004968254347 15047.619089155092 1.3807717985067918 2.0863317084414343 1.4476749669470863 1.2487734811017175 1.03459401976094 0.9594072314823038 1.294529570925962 1.3305820552842096 1.1557977953328755 1.0 13.87724761404271 -5.614298040216815 3.0958506419091867 1.15083739491896 1.7415094908751279 0.5857560944158436 0.19807313627313042 0.1613464772808694 3.0792792428138824 0.05465153432738626 0.1063923500621692 2.4305354501509513e-06 5.614298040216815 0.5906720959561678 SDSLS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 SDSLSPPR 8 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9;Q9UPQ0-7;D6R8Y0 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 SDS(0.001)LS(0.999)PPR 109.83 0.012283 26482000.0 124080.0 116940.0 149380.0 129380.0 133710.0 100000.0 100700.0 97882.0 99185.0 114680.0 True False 117184.1303315948 125908.92197863519 139769.0534326463 111758.22080705094 116912.1544174335 113774.09229038189 105382.74953326449 98166.82041476257 119024.77146045065 111368.89042557628 1.0522160172719386 1.130557389029349 1.2550098407063577 1.0034958629828035 1.049773899790818 1.021596712112463 0.9462494340256348 0.8814563927110671 1.0687434435740428 1.0 16.764986763697017 -6.263557187279568 1.4528572433056615 0.9738040454887321 1.1374810084803195 0.43092397836928276 0.07262719628261904 0.36845150249329217 1.5595287142127043 0.027839541781068775 0.03844687806205675 5.450581184855884e-07 6.263557187279568 0.1636769629915874 SDSPES(ph)DAER ddPTM_A459_Selumetinib_30min_R1 1 SDSPESDAER 10 0 O75400-3;O75400;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 SDS(0.01)PES(0.99)DAER 119.03 0.0055279 896240.0 629.14 847.68 355.22 708.78 626.42 542.27 672.06 543.63 384.17 605.54 True False 643.7977379066641 748.4332315242598 306.98307508379094 585.0048784484071 569.7604216034334 536.8152561417661 621.3659731213897 529.2111664408936 651.9084313333516 683.2669574590893 0.9422345554375964 1.0953745433666346 0.4492871662130267 0.8561878663412965 0.8338767379037906 0.785659617052253 0.9094043936093515 0.774530599882814 0.9541050159335192 1.0 9.416305550068103 -8.4183800299327 4.700638205950918 0.9984446175931734 0.829338266251614 0.12728662111279943 0.1549951750052486 0.4418462711583841 14.42773776210645 0.14916964746854514 0.03893353123311097 3.81610196212918e-09 8.4183800299327 -0.16910635134155938 SDSPES(ph)DAEREK ddPTM_A459_Selumetinib_30min_R1 1 SDSPESDAEREK 12 1 O75400-3;O75400;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 SDS(0.017)PES(0.983)DAEREK 143.58 0.0038644 78190000.0 3274.3 3603.2 3007.0 3394.1 2828.8 2503.1 2763.7 3074.1 1693.2 2355.7 True False 3350.5848193212796 3181.3356689177667 2598.6659162686774 2801.3841501477746 2572.9355394652052 2477.9210866329577 2555.2318839323657 2992.5648819159187 2873.2367335649083 2658.077041461135 1.2605296110903825 1.1968560802771158 0.977648832495916 1.0539138280987763 0.9679687606236094 0.9322232004497708 0.961308436164726 1.1258382790405943 1.0809456192381468 1.0 11.376167204822888 -5.154282169378829 4.025213692700308 1.012181730387963 1.2470467670242695 0.7008640186983803 0.05696714687455236 0.13420287891002733 3.731084234999567 0.01635752817108127 0.04974223924532648 7.009996976034366e-06 5.154282169378829 0.23486503663630653 SDSPVPTAPT(ph)SGGPKPSTASAVPELATDPELEKK ddPTM_A459_Selumetinib_30min_R1 1 SDSPVPTAPTSGGPKPSTASAVPELATDPELEKK 34 2 B4E349;F5H6D8;B4DTN4;Q86U44 B4E349 METTL3 N6-adenosine-methyltransferase 70 kDa subunit 1 S(0.004)DS(0.004)PVPT(0.076)APT(0.255)S(0.255)GGPKPS(0.076)T(0.076)AS(0.255)AVPELATDPELEKK 65.73 0.00017775 136780000.0 5805.7 6211.8 7847.2 7900.0 5974.7 5631.4 5921.7 5894.7 3606.0 5397.6 True False 5940.9615140743235 5484.519568212528 6781.593341584155 6520.413301366315 5434.289439918961 5574.753228902098 5475.021401411976 5738.353407315882 6119.118628180402 6090.434537076296 0.9754577408078132 0.9005136718611483 1.1134826752180558 1.070599028964595 0.8922662918116978 0.9153293077801063 0.8989541498364502 0.9421911314181155 1.004709695331177 1.0 12.57232944910248 -6.2673571524595175 24.984841173008956 0.9358413170656444 1.0138682640474583 0.23728733721429573 0.06328170813449309 721.128399813689 3044601.7186121894 0.02077205076597956 0.02417689701975012 5.403098034939385e-07 6.2673571524595175 0.0780269469818139 SDSQAS(ph)LTVPLSPQVVR ddPTM_A459_Selumetinib_30min_R2 1 SDSQASLTVPLSPQVVR 17 0 Q8TEV9-2;Q8TEV9 Q8TEV9-2 SMCR8 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 1 SDS(0.319)QAS(0.673)LT(0.008)VPLSPQVVR 108.25 0.0023599 2177800.0 10014.0 6981.4 9140.6 10756.0 9278.0 8843.9 7163.7 8688.8 6735.6 10259.0 True False 9457.461969218177 7516.850931260864 8552.5037475328 9291.014244865066 8112.414693627618 10062.066948069083 7496.826244602255 8714.082969491725 8082.908208388466 9962.796013916884 0.9492778890591743 0.7544921045016564 0.8584441290964838 0.9325709601889453 0.8142708816175203 1.0099641640773864 0.7524821580337536 0.8746623896865046 0.8113092145114252 1.0 13.282334969658848 -11.963425874913685 2.2471086381330276 2.3599165794405437 0.8608620152867457 0.21371332608212668 0.07941930226482012 5363808.056878779 525360.398527427 37242176.173084565 0.019554040032169914 1.087862797467583e-12 11.963425874913685 -1.499054564153798 SDSQASLTVPLS(ph)PQVVR ddPTM_A459_Selumetinib_30min_R1 2 SDSQASLTVPLSPQVVR 17 0 Q8TEV9-2;Q8TEV9 Q8TEV9-2 SMCR8 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 1 SDSQASLT(0.002)VPLS(0.998)PQVVR;SDSQASLTVPLS(1)PQVVR 269.99 1.3807e-51 88075000.0 3417.8 4304.8 4375.700000000001 4854.1 4322.0 3544.3999999999996 3925.7 3325.5 1976.0 3169.6000000000004 True False 3497.428090118887 3800.792014752775 3781.503973999616 4006.422557742057 3931.075863111078 3508.7465540577114 3629.5812884007955 3237.2969372536295 3353.127678670125 3576.4490345184954 0.9779051948910976 1.062727856057505 1.0573347858454043 1.1202235846432103 1.099156125299106 0.9810699160515511 1.0148561473599897 0.905170717101935 0.9375577972192642 1.0 11.804312167492993 -7.153436725000848 1.8358037059904586 0.9484471534542301 1.0642886900199324 0.5001688632337338 0.046377992915989735 0.28356852730204946 1.8797995500755114 0.023662615718401968 0.01610779286430664 7.023656681988707e-08 7.153436725000848 0.11584153656570229 SDSQASLTVPLS(ph)PQVVR ddPTM_A459_Selumetinib_30min_R2 4 SDSQASLTVPLSPQVVR 17 0 Q8TEV9-2;Q8TEV9 Q8TEV9-2 SMCR8 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 1 SDSQASLT(0.001)VPLS(0.999)PQVVR;SDSQASLTVPLS(1)PQVVR;SDSQASLTVPLS(1)PQVVR;SDSQASLTVPLS(1)PQVVR 316.32 5.2761999999999976e-104 74199000.0 186546.0 166778.0 177439.0 200653.0 215701.0 151222.0 164766.0 153589.0 139945.0 175538.0 True False 176178.52012280544 179569.33632420763 166022.76792097618 173323.71525426852 188602.71198859336 172051.4578433614 172427.94547763496 154035.91856197218 167937.91039000623 170469.7618375028 1.0334883924501779 1.0533794051720378 0.9739132977685179 1.0167416988561655 1.1063704785859645 1.0092784549518308 1.011486985251958 0.9035967253172098 0.9851477973559323 1.0 17.379156329135327 -7.567475292599089 9.515710880467026 0.9579375173031995 1.0313011712000268 0.37938579107421977 0.039473044292662345 0.36736461434106177 74.28847353633137 0.018727749794124813 0.010807276691384054 2.7072272161143148e-08 7.567475292599089 0.07336365389682731 SDSS(ph)LETMENTGVMDK ddPTM_A459_Selumetinib_30min_R1 1 SDSSLETMENTGVMDK 16 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 SDS(0.051)S(0.949)LETMENTGVMDK 191.15 1.0469e-06 2559400.0 1419.3 1629.1 1313.2 1262.5 1396.7 1560.6 1478.8 1312.6 877.21 1296.5 True False 1452.3669285229494 1438.3642146519564 1134.8746528912618 1042.028075060123 1270.3687316074138 1544.9017809114273 1367.2529254112892 1277.7855840743089 1488.5613011165083 1462.9184039794377 0.9927873793727756 0.9832156125313013 0.7757607326588895 0.7122940501846127 0.8683797593575627 1.0560409772062325 0.9346064152943057 0.8734496610326798 1.017528590157398 1.0 10.514633588344163 -6.614146118544903 10.940314488239377 0.9656982430371753 0.8582715874369353 0.260544754724908 0.09128283884436636 0.6638818008104727 74.76992305726672 0.03320923421579989 0.033201656928705005 2.4313858307486155e-07 6.614146118544903 -0.10742665560024 SDSS(ph)LETMENTGVMDK ddPTM_A459_Selumetinib_30min_R2 1 SDSSLETMENTGVMDK 16 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 SDS(0.043)S(0.957)LETMENTGVMDK 281.68 2.7075999999999982e-130 0.0 13282.0 11227.0 19059.0 15914.0 18087.0 14553.0 12902.0 14996.0 13336.0 14383.0 True False 12543.839612058704 12088.074799505226 17832.764689870208 13746.485746818777 15814.749360168425 16557.543651019267 13501.968564827994 15039.635877278564 16003.572638973308 13967.725418478078 0.8980588632895304 0.8654290113344985 1.276712145721237 0.9841606514281401 1.1322351267907154 1.1854144576120522 0.9666547816701831 1.0767419480757006 1.1457536685108358 1.0 13.76980948299845 -5.225070063744386 24.910301955912313 1.0945794943774059 0.8817437911193561 0.4669023052242882 0.09154939735265252 468.3941368151068 320814.03094304394 0.022187214389266605 0.05869815849423927 5.955660544566572e-06 5.225070063744386 -0.2128357032580498 SDSSLETMENT(ph)GVMDK ddPTM_A459_Selumetinib_30min_R1 1 SDSSLETMENTGVMDK 16 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 SDS(0.001)S(0.001)LETMENT(0.998)GVMDK 88.075 0.025814 0.0 747.47 1498.5 1270.0 1151.3 1262.4 1401.8 1265.7 1287.6 438.76 1319.1 True False 764.8845966765653 1323.0549233662507 1097.5409756106487 950.2470675776003 1148.2161428948225 1387.699164732564 1170.2272299790843 1253.4486652857545 744.5436742375024 1488.4193341220807 0.5138905274485162 0.8888993128718209 0.7373869382434588 0.6384269847838866 0.7714332356291774 0.9323307840199987 0.7862214653838283 0.8421340925573775 0.5002244039490786 1.0 10.53956532053731 -6.512899620011201 24.015855854159884 0.8063806456708322 0.7107473472400258 0.11620804326817757 0.15006627554934404 782.0263532753887 1882039.09782902 0.04688587752134071 0.04970184991994447 3.069731424064092e-07 6.512899620011201 -0.09563329843080648 SDSTEPHS(ph)PSDLLPMSPSVYAVLR ddPTM_A459_Selumetinib_30min_R2 2 SDSTEPHSPSDLLPMSPSVYAVLR 24 0 Q14765 Q14765 STAT4 Signal transducer and activator of transcription 4 1 S(0.009)DS(0.024)T(0.024)EPHS(0.941)PS(0.002)DLLPMSPSVYAVLR;S(0.028)DS(0.026)T(0.026)EPHS(0.567)PS(0.353)DLLPMSPSVYAVLR 65.223 0.01764 0.0 2105.31 1212.0900000000001 6105.3 7078.799999999999 8280.6 5737.4 2941.6 5138.7 5040.0 5422.1 True False 1988.305298423679 1305.05340551637 5712.491644948033 6114.655228388883 7240.316998496746 6527.674771068369 3078.39022866982 5153.652766242417 6048.140829366036 5265.549884692345 0.37760639286771314 0.24784750578668607 1.084880358185383 1.1612567276525099 1.3750353062925702 1.2396947923796506 0.5846284426283969 0.9787492055150351 1.1486247328030805 1.0 12.362368485332647 -5.2639066428155274 24.795026667178863 1.0734990625348586 0.31272689795755804 0.7005741871446151 0.19844716796322326 103.54275913517974 1040577.8571395011 0.0568275841231373 0.1278780144677052 5.446197132720281e-06 5.2639066428155274 -0.7607721645773006 SDSVLPAS(ph)HGHLPQAGSLER ddPTM_A459_Selumetinib_30min_R2 1 SDSVLPASHGHLPQAGSLER 20 0 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 SDSVLPAS(0.996)HGHLPQAGS(0.004)LER 91.401 0.00080804 24369000.0 46407.0 36023.0 67116.0 74893.0 81350.0 64731.0 51867.0 50922.0 58585.0 62765.0 True False 43827.884721940056 38785.84826779874 62797.82963037564 64692.444202368875 71130.08572177257 73647.107680487 54278.91827251071 51070.174589409056 70303.63700166838 60952.81136694544 0.7190461561828436 0.6363258297357587 1.030269617135835 1.0613529179632135 1.1669697283289913 1.208264328237789 0.8905072146015243 0.8378641352891606 1.1534108997602999 1.0 15.895405144309807 -5.267041164374659 23.21746862166113 1.0432455649124914 0.6776859575267581 0.6296833617284397 0.11223794451168204 103.44069130806663 428732.4700806825 0.03178360854315413 0.06948112349416861 5.407030702597502e-06 5.267041164374659 -0.36555960738573334 SDSVLPASHGHLPQAGS(ph)LER ddPTM_A459_Selumetinib_30min_R1 4 SDSVLPASHGHLPQAGSLER 20 0 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER 161.46 4.727e-07 77425800.0 15329.999999999998 15122.800000000001 15505.0 15583.099999999999 21741.600000000002 14353.9 19585.2 15049.9 4706.12 9752.1 True False 15687.159173012606 13352.21554560102 13399.506162868585 12861.80411601537 19775.076118791247 14209.512798298429 18107.872595865014 14650.727763035156 7985.9419185946645 11003.877028498173 1.42560291544385 1.2134101018232983 1.217707734116452 1.1688429525980235 1.7971007916189137 1.2913187562436588 1.6455902359658054 1.3314150753495573 0.7257389280080494 1.0 13.425724301872812 -10.340386589718957 9.278626648183407 0.9999721934756547 1.3269284741534864 0.1039391736114873 0.27292263514043164 0.0 0.0 0.26483137601833384 0.06423104331183874 4.566814909859392e-11 10.340386589718957 0.32695628067783167 SDSVLPASHGHLPQAGS(ph)LER ddPTM_A459_Selumetinib_30min_R2 5 SDSVLPASHGHLPQAGSLER 20 0 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER;SDSVLPASHGHLPQAGS(1)LER 121.35 0.00016321 81244900.0 133315.0 121737.0 163714.0 193388.0 198742.0 148937.0 135278.0 140435.0 136071.0 181069.0 True False 125905.88600222902 131073.83645384922 153180.819478326 167048.2207870923 173774.25318397736 169451.719834526 141568.69504827153 140843.6425997341 163289.0021414021 175841.06749623897 0.7160209375146224 0.7454108321803309 0.8711322199042175 0.9499954883444122 0.9882461228102711 0.9636640760165448 0.805094606533252 0.8009712668671474 0.9286169861593604 1.0 17.423912524178583 -5.290104257436083 3.0291496798958204 0.9112206495838309 0.7213555047169135 0.567802379363668 0.06482252012337758 0.21044336657204998 3.859387464306677 0.019442242281959607 0.05445181685978527 5.127382804344441e-06 5.290104257436083 -0.1898651448669174 SDSYSQS(ph)LK ddPTM_A459_Selumetinib_30min_R1 1 SDSYSQSLK 9 0 Q9H8W4 Q9H8W4 PLEKHF2 Pleckstrin homology domain-containing family F member 2 1 S(0.009)DS(0.393)YS(0.179)QS(0.418)LK 86.189 0.041645 0.0 1670.4 1677.2 1839.6 1967.3 1556.5 1627.8 2109.0 1503.7 842.4 1297.9 True False 1709.317069967401 1480.832644290874 1589.7924241994872 1623.7479857946773 1415.7148498223937 1611.4258099241463 1949.91643203436 1463.8169912940268 1429.491273538317 1464.4981076165932 1.1671691899617678 1.0111536755078943 1.0855544407543176 1.1087402416908934 0.9666894361006775 1.100326317626092 1.3314571196051348 0.9995349148496512 0.9760963610016211 1.0 10.516190613670476 -7.961751730760022 24.999999061183736 0.9879688491646641 1.1041688267501233 0.25839759071264845 0.09156925124513504 227.4500207402342 148666.64345468153 0.051844976659098985 0.0249054610079028 1.0920644487519704e-08 7.961751730760022 0.11619997758545919 SDTDTGVCS(ph)GTDEDPDDKNAPFR ddPTM_A459_Selumetinib_30min_R2 3 SDTDTGVCSGTDEDPDDKNAPFR 23 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83;Q5JSH3-3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 S(0.011)DT(0.011)DT(0.04)GVCS(0.88)GT(0.058)DEDPDDKNAPFR;SDTDT(0.005)GVCS(0.979)GT(0.015)DEDPDDKNAPFR;SDTDT(0.001)GVCS(0.628)GT(0.371)DEDPDDKNAPFR 114.71 4.1526e-05 18633100.0 127168.0 93681.0 120126.0 124728.0 122001.0 89256.0 93507.0 107721.0 84344.0 107681.0 True False 120100.51165383846 100866.03146810812 112397.22394329972 107739.8312321988 106674.14367722168 101550.20381470324 97855.26078060546 108034.45027582833 101215.15676826368 104571.96974116252 1.1484962170179287 0.964560882976314 1.0748312786065553 1.0302936006549117 1.0201026521854994 0.9711034808473171 0.9357695090072194 1.033110981300593 0.9678994956181121 1.0 16.674136666989753 -6.416236565489163 2.0981391328707693 0.981260662833189 1.051687547966412 0.33562834012372766 0.04834481976766803 0.4031967411399273 3.50644431314739 0.016438566906235304 0.019076428885540845 3.834982924011906e-07 6.416236565489163 0.07042688513322304 SDTEIS(ph)LEVTDVEESVEKEK ddPTM_A459_Selumetinib_30min_R1 1 SDTEISLEVTDVEESVEKEK 20 1 P26374 P26374 CHML Rab proteins geranylgeranyltransferase component A 2 1 S(0.016)DT(0.061)EIS(0.903)LEVT(0.02)DVEESVEKEK 90.084 0.0009577 2282700.0 732.54 909.91 1287.6 1059.3 806.67 1055.1 911.83 965.49 515.29 705.74 True False 749.6067567252873 803.3773141943173 1112.7509922805284 874.3131405237132 733.7068409291562 1044.4866519541504 843.0499289814555 939.8820688464912 874.4094947074534 796.3286034897404 0.9413284333129507 1.0088515101349962 1.3973515297631334 1.0979300965609198 0.9213619072752659 1.3116276966278873 1.0586709120920295 1.1802691310191022 1.0980510945802275 1.0 9.637220068783112 -5.016473819249204 24.895313778611303 1.1390616636640587 0.958209074208886 0.1923657763231923 0.13230395981446694 906.2728899997309 1369577.1952726797 0.0326741753579727 0.09200219406678271 9.62778050764554e-06 5.016473819249204 -0.18085258945517269 SDTEISLEVTDVEES(ph)VEKEK ddPTM_A459_Selumetinib_30min_R1 2 SDTEISLEVTDVEESVEKEK 20 1 P26374 P26374 CHML Rab proteins geranylgeranyltransferase component A 2 1 SDTEISLEVTDVEES(1)VEKEK;SDTEISLEVTDVEES(1)VEKEK 139.55 4.1417e-05 13753700.0 2761.3 3889.7 4119.9 3796.7 2241.83 3176.9 2913.5 2608.7 2218.8 2607.0 True False 2825.632917445513 3434.2921157275273 3560.440208990794 3133.677617885758 2039.0568723272331 3144.943270394408 2693.7323493276936 2539.508801748171 3765.1415452597544 2941.6338443304253 0.9605658171534547 1.1674777682975839 1.210361451291101 1.0652847307714621 0.6931715435138949 1.0691144570748778 0.9157265968092779 0.8632987435342124 1.279949084253474 1.0 11.522401965026425 -6.011298935849864 24.91309500764516 0.9577444269311839 1.1215282802166486 0.1504254638918643 0.15316675759569334 856.9797297339535 1889565.5730821125 0.04331448053651047 0.05952030730530049 9.743187586671168e-07 6.011298935849864 0.16378385328546474 SDTS(ph)SPEVR ddPTM_A459_Selumetinib_30min_R1 2 SDTSSPEVR 9 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.001)DT(0.071)S(0.464)S(0.464)PEVR;S(0.035)DT(0.189)S(0.388)S(0.388)PEVR 131.12 0.0036806 15401300.0 8923.4 10202.9 9222.4 10067.3 10018.3 8904.3 9231.6 8808.4 5629.6 7617.6 True False 9131.29785808616 9008.33972480048 7970.048735017038 8309.235041625965 9112.146533874517 8814.730826457531 8535.252979596204 8574.772618284434 9553.020030284073 8595.393161707503 1.0623478980305536 1.0480427777210535 0.9272465592991864 0.9667079661514062 1.060119806324759 1.025518049101835 0.9930032075345635 0.9976009772868875 1.1114116423251934 1.0 13.069347916159845 -6.26294835242232 24.98975446686837 1.0289541627212875 0.9991660685123479 0.08346294488728578 0.04847989142554792 426.9783003582846 7071036.611607588 0.015562127059138538 0.018657294890701937 5.458227680813681e-07 6.26294835242232 -0.029788094208939575 SDTSGHFER ddPTM_A459_Selumetinib_30min_R1 4 SDTSGHFER 9 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 ;;; 131.52 0.005036100000000001 3730430.0 4074.14 4349.15 4157.990000000001 3981.8500000000004 5658.209999999999 4454.36 3978.166 3914.0 1634.78 2982.4999999999995 False True 4169.0595351035645 3839.9494961350174 3593.357796204189 3286.494646081705 5146.425904538114 4409.553182635284 3678.08973578018 3810.1880055362226 2774.1022603928877 3365.33292701016 1.238825288767924 1.141031089469807 1.067757001800298 0.9765734081476163 1.5292471847979447 1.3102873558940376 1.0929348791199331 1.1321875392938558 0.8243173322104166 1.0 11.716533520073458 -8.061196622442989 2.823322307261895 0.9149116711370586 1.195641612556893 0.34954169960486814 0.14936415437589995 0.33605139499969877 4.985294237359076 0.12711269748023415 0.04282508735498019 8.685671052665366e-09 8.061196622442989 0.2807299414198343 SDTSGHFER ddPTM_A459_Selumetinib_30min_R2 2 SDTSGHFER 9 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 ; 128.91 0.0059172 7100800.0 38629.0 35170.0 58914.0 71053.0 85792.0 48865.0 50906.0 51833.0 60876.0 70618.0 False True 36482.15482413912 37867.42591062606 55123.537380713235 61375.458826738286 75014.04196978887 55595.710197695094 53273.229868325354 51983.825448584896 73052.9010175569 68579.07485240094 0.5319721052326486 0.5521717228196222 0.8037952903178216 0.894958979234313 1.093832807328439 0.8106803761548367 0.7768146476601276 0.7580129297525068 1.065236023886072 1.0 16.065480821664117 -5.345916213771685 2.635239005730414 0.9005981141388498 0.5264622938664667 0.6445275036303948 0.1088199051210971 0.18824437052713625 2.501255806552258 0.03140370117074383 0.0876232829933821 4.509036867085054e-06 5.345916213771685 -0.3741358202723831 SDTSGHFQR ddPTM_A459_Selumetinib_30min_R1 2 SDTSGHFQR 9 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 ; 163.16 0.0011609 1611400.0 2277.7 2430.9 2542.7 2163.4 2712.3999999999996 2619.1000000000004 2162.4 2384.4 1355.4 1810.26 False True 2330.7659783673066 2146.28909790525 2197.415306051334 1785.6028020475815 2467.063898913113 2592.7542319525305 1999.288427041772 2321.1579663772536 2300.014805500753 2042.6245044256218 1.1410643382165382 1.0507506853340027 1.0757803508624992 0.8741708513624662 1.207791198807165 1.2693249426583195 0.9787841195041201 1.1363605799049954 1.1260096021160328 1.0 10.996208302540042 -4.735459950556664 22.76616974777336 1.0843477951143576 1.1410651261704883 0.026419356096451407 0.10841153689146844 4272.042311569759 3743043.5513032903 0.027610049838930544 1.6913944402526577 1.8388235172957904e-05 4.735459950556664 0.05671733105613064 SDTSGHFQR ddPTM_A459_Selumetinib_30min_R2 2 SDTSGHFQR 9 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 ; 131.11 0.0051749 3925900.0 22837.0 16777.6 26246.0 32394.0 37549.0 23782.3 26643.0 34493.0 33672.0 41889.0 False True 21567.810963754295 18064.3879715132 24557.36093448415 27981.881317233096 32831.75892768089 27058.09595077549 27881.952292102946 34593.36891937645 40407.340874288304 40679.55572930737 0.5301879673237404 0.44406551762065594 0.6036781988941912 0.687861035244141 0.8070825341887257 0.6651521990758033 0.6854045427053556 0.8503870875476115 0.9933083129808383 1.0 15.312016302829793 -5.50192282053404 0.19924473214356564 1.0769365594623301 0.09843477680461371 0.8151561360395558 0.07547384110444078 4.810826634909862 0.24232726028008655 0.2082305558973578 1.203289808772778 3.148307757364145e-06 5.50192282053404 -0.9785017826577165 SDVLELTDDNFESR ddPTM_A459_Selumetinib_30min_R1 4 SDVLELTDDNFESR 14 0 H7BZJ3 H7BZJ3 PDIA3 0 ;;; 284.12 7.8681e-54 31450600.0 4858.299999999999 6154.82 6080.39 6869.76 6607.82 6104.13 5888.14 5486.16 3543.4900000000002 5064.84 False True 4971.488937393811 5434.2108131018085 5254.706435191517 5670.085377366359 6010.143847705374 6042.727994306597 5443.992859231291 5340.649215240832 6013.043723730163 5714.961549719415 0.8699076790180493 0.9508744312319318 0.9194648799429813 0.9921475985511645 1.0516507933461865 1.057352344672078 0.9525860868650239 0.9345030878647012 1.0521582116375539 1.0 12.480528076677391 -5.788407957600668 4.2554158625146 1.005846099752505 0.9158755503287329 0.4979700512933285 0.042682590525849266 0.1930817750918447 7.837730070364725 0.012949258091021477 0.02097238006487776 1.6277662604736141e-06 5.788407957600668 -0.08997054942377203 SDVLELTDDNFESR ddPTM_A459_Selumetinib_30min_R2 1 SDVLELTDDNFESR 14 0 H7BZJ3 H7BZJ3 PDIA3 0 135.02 0.0084038 14130000.0 22818.0 21607.0 26273.0 27971.0 31197.0 21036.0 22992.0 23252.0 17391.0 25804.0 False True 21549.866907691277 23264.187422544688 24582.62378387953 24161.30154733367 27277.7539552814 23933.51805420473 24061.17355778368 23319.65947042418 20869.685945139823 25058.971473156387 0.8599661375079131 0.9283775851481254 0.9809909321383311 0.9641777027128062 1.0885424401596775 0.955087804774539 0.9601820084099795 0.9305912453511753 0.8328229260125779 1.0 14.613039581079612 -10.638383841384911 16.878594644094235 0.9999999839596875 0.9502990019279207 0.05408172323308924 0.06572371457030993 0.0 0.0 0.0668392677229087 0.016210903574146462 2.299408638575455e-11 10.638383841384911 -0.04970098203176676 SDVS(ph)PIIQPVPSIK ddPTM_A459_Selumetinib_30min_R2 1 SDVSPIIQPVPSIK 14 0 P40818;P40818-2;A0A075B720 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 S(0.026)DVS(0.974)PIIQPVPSIK 156.72 0.00031875 5308900.0 43378.0 35092.0 45794.0 40289.0 47549.0 34578.0 31470.0 37979.0 26071.0 38203.0 True False 40967.22441589237 37783.44356143557 42847.66389673728 34801.56869759845 41575.46952654662 39340.80563216822 32933.417356621976 38089.512602238065 31285.92848460353 37099.980126685514 1.1042384463819483 1.0184222048749414 1.1549241738250295 0.9380481762729073 1.1206332020820127 1.0603996416664092 0.8876936657152927 1.026672048668856 0.8432869337873307 1.0 15.179130793588522 -7.241520557383585 22.409292070660033 0.9416358553550511 1.0646375611588033 0.41503154984035395 0.07365725090806928 206.5955029750555 232426.20945401295 0.026152479432707675 0.020213860532592432 5.734287225832796e-08 7.241520557383585 0.12300170580375214 SDVYYFS(ph)PSGK ddPTM_A459_Selumetinib_30min_R1 1 SDVYYFSPSGK 11 0 X6RBL6;Q9UBB5-3;Q9UBB5 X6RBL6 MBD2 Methyl-CpG-binding domain protein 2 1 SDVYYFS(0.749)PS(0.251)GK 104.7 0.012121 5346100.0 1869.8 2424.6 2171.6 2024.5 2184.8 2005.4 2132.0 1998.5 1172.7 1831.9 True False 1913.3627020025435 2140.7267048340395 1876.7086477449475 1670.9590795716583 1987.1852257577693 1985.2274967575133 1971.1815235169533 1945.493287957114 1989.9862493807977 2067.042209217073 0.9256524581214343 1.035647310581469 0.9079198476821537 0.8083816925076543 0.9613665443776541 0.9604194282561127 0.9536242243759364 0.9411966912344777 0.9627216321501914 1.0 11.013352133709146 SDYDMVDYLNELR ddPTM_A459_Selumetinib_30min_R2 2 SDYDMVDYLNELR 13 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 ; 153.38 0.0018035 2462700.0 10832.1 10053.0 14716.9 14982.5 16970.5 12172.2 12246.1 11447.8 12414.1 11731.5 False True 10230.095246331955 10824.032774510193 13770.030676549177 12941.857653745901 14838.514071805073 13848.810061769851 12815.5679151868 11481.111202714686 14897.266878935088 11392.78111290242 0.8979453870790415 0.9500781826003737 1.208662796211761 1.1359700081562296 1.302448798476461 1.2155776473301991 1.1248849414541164 1.0077531630720291 1.3076058190974817 1.0 13.475832348547002 -5.190543532839479 4.910572059778621 1.1676657161617923 0.913503106760201 0.4803252899560262 0.09954965732514201 0.1755451835706081 8.022588972428919 0.02517842657758762 0.0705790759754411 6.4484667844368055e-06 5.190543532839479 -0.2541626094015913 SEAAEPPKT(ph)PPSSCDSTNAAIAK ddPTM_A459_Selumetinib_30min_R1 1 SEAAEPPKTPPSSCDSTNAAIAK 23 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 SEAAEPPKT(1)PPSSCDSTNAAIAK 146.15 2.0936e-07 0.0 1062.3 1424.5 1468.1 1744.5 1087.2 983.82 1213.9 1218.4 670.97 1308.8 True False 1087.0495231240252 1257.7188777679166 1268.7400836960576 1439.8558233207007 988.86295196075 973.9236640370884 1122.3345456835032 1186.0840740790331 1138.5870842901281 1476.7972287915836 0.7360858362481648 0.8516530592335064 0.8591159699928659 0.9749854585648763 0.669599680092781 0.6594836752463432 0.7599787728487776 0.803146194315091 0.7709840336183443 1.0 10.528256035545255 -4.731320572253685 23.22475794762341 0.8054109355767656 0.736084837765316 0.03946753559466154 0.10706861151443155 6524.312643063848 5030255.222405337 0.027584220476953778 2.7650284799019462 1.856433632216988e-05 4.731320572253685 -0.0693260978114496 SEAAEPPKT(ph)PPSSCDSTNAAIAK ddPTM_A459_Selumetinib_30min_R2 1 SEAAEPPKTPPSSCDSTNAAIAK 23 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 SEAAEPPKT(0.927)PPS(0.058)S(0.013)CDS(0.001)T(0.001)NAAIAK 104.82 0.0014193 0.0 15794.0 15764.0 12928.0 15796.0 14130.0 13578.0 16092.0 11724.0 9470.1 12960.0 True False 14916.232708391442 16973.04811075089 12096.226554942132 13644.557550380114 12354.863076197267 15448.246251188046 16840.309885693074 11758.11489898731 11364.384616702238 12585.811125876098 1.185162605668224 1.3485859545321435 0.9611002766498383 1.0841222241391546 0.9816501258942296 1.2274335040215927 1.3380392981640918 0.9342357660852653 0.9029521024145485 1.0 13.61951057734112 -1.5228787452983787 0.1499131040936614 0.9592994567011516 1.9130983147363023 0.17331956869587783 0.1442403064036916 142.2750604673369 1.403516779018818 0.5581129447191732 29.494721388876787 0.02999999999875376 1.5228787452983787 0.9537988580351507 SEAAGSPDQGSTYS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 SEAAGSPDQGSTYSPAR 17 0 Q96S66-4;Q96S66-3;Q96S66-2;Q96S66 Q96S66-4 CLCC1 Chloride channel CLIC-like protein 1 1 SEAAGSPDQGS(0.002)T(0.027)YS(0.971)PAR 199.31 3.7355e-21 0.0 12958.0 4369.6 10793.0 11047.0 7864.8 7488.3 19122.0 10220.0 10968.0 11092.0 True False 12237.84623498394 4704.734269521512 10098.590130529885 9542.379542862069 6876.7535117959105 8519.745352980668 20011.210889524165 10249.738507987915 13161.906471525135 10771.745139522962 1.1361061811685145 0.4367662072006529 0.9375073397788458 0.8858712696283365 0.6384066298193586 0.7909345461322318 1.8577501259383105 0.9515392701207035 1.221891745584692 1.0 13.394964380608611 -7.093390318963828 24.999999999823686 1.2638436934840467 0.7895897929718767 0.3750470209726182 0.2863908571136359 57.19326597482235 15306.810505332636 0.10390252258741454 0.08048255858916818 8.065098596363259e-08 7.093390318963828 -0.47425390051217 SEAAPASLEGGS(ph)LKSPPPFFYR ddPTM_A459_Selumetinib_30min_R2 1 SEAAPASLEGGSLKSPPPFFYR 22 1 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 SEAAPAS(0.341)LEGGS(0.629)LKS(0.028)PPPFFY(0.002)R 51.487 0.024699 5610400.0 9487.5 9625.1 10078.0 11081.0 11414.0 8398.9 10212.0 11293.0 12705.0 11126.0 True False 8960.22273147169 10363.314220425555 9429.59245209675 9571.7486842088 9980.071277545338 9555.772237376876 10686.878234694115 11325.86076034321 15246.355007360218 10804.763471180351 0.8292844869183279 0.9591430898110561 0.8727254860551451 0.885882297168246 0.923673276528938 0.8844036487115223 0.9890895125283703 1.048228477240875 1.4110771649955103 1.0 13.399379869822745 -7.845323018195734 2.4774448932019912 1.2076936961601095 0.9003474867362304 0.5767073363701996 0.10220814428689451 0.18362829411683865 2.213764277772638 0.06499777365005645 0.02627897359088098 1.4278315753545482e-08 7.845323018195734 -0.307346209423879 SEAAPASLEGGSLKS(ph)PPPFFYR ddPTM_A459_Selumetinib_30min_R1 1 SEAAPASLEGGSLKSPPPFFYR 22 1 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 SEAAPASLEGGS(0.001)LKS(0.999)PPPFFYR 81.94 0.00053877 23731000.0 768.41 1182.3 880.58 1297.3 949.22 732.0 974.01 1190.2 876.39 882.22 True False 786.3124579344174 1043.875766363642 761.0020726797039 1070.750908337028 863.3632185984021 724.6367446028228 900.5396415200497 1158.6320296855426 1487.1698210069378 995.4615305505127 0.7898973830757365 1.0486349641119281 0.7644716036980882 1.0756326341861533 0.8672994305675908 0.7279404802334072 0.9046453467890727 1.1639144197212652 1.4939500677484736 1.0 9.959221754081753 -7.832488313420258 3.949106970274447 1.2685587433709675 0.8841068539796142 0.5043883565886307 0.15369050380339347 0.16504483176611803 4.990400032185569 0.08579293409094907 0.039366720189838 1.470657989314288e-08 7.832488313420258 -0.38445188939135333 SEAHLTELLEEICDR ddPTM_A459_Selumetinib_30min_R1 1 SEAHLTELLEEICDR 15 0 F8W031;F8VXJ7;F8W1K5;Q9Y2B0 F8W031;Q9Y2B0 CNPY2 Protein canopy homolog 2 0 144.8 0.00058181 0.0 727.4 1093.1 812.54 716.02 1242.4 1063.0 919.65 589.01 417.14 504.01 False True 744.3470047259864 965.1193438315969 702.2015309627373 590.980548360039 1130.0251393635363 1052.307185126777 850.280060085537 573.3875414258791 707.8561132998257 568.7045929731408 1.3088464800936483 1.6970486184857982 1.234738631688704 1.0391696421343133 1.987016024357844 1.8503581615639881 1.4951172728188158 1.008234412928259 1.2446815482871558 1.0 9.151535645608417 -7.740581775368566 11.711090951417935 1.094858131383123 1.52492898193842 0.3407030142101938 0.2749096534497555 0.7526152561715904 420.10828662712595 0.14140794591856384 0.08025401568723646 1.817264842458551e-08 7.740581775368566 0.43007085055529704 SEALS(ph)SVLDQEEAMEIK ddPTM_A459_Selumetinib_30min_R1 1 SEALSSVLDQEEAMEIK 17 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 S(0.013)EALS(0.966)S(0.021)VLDQEEAMEIK 183.88 5.8611e-14 0.0 349.3 555.73 522.92 576.65 297.93 342.46 395.99 486.36 354.92 477.86 True False 357.43801038051566 490.66487324813215 451.9103361939526 475.9489025611247 270.9822841038138 339.01516332880146 366.1201554866219 473.46015288007084 602.2733176688264 539.1979857505703 0.662906798294058 0.9099901821130146 0.8381157721961587 0.8826978496564633 0.502565460675086 0.6287396694497813 0.6790087596061364 0.8780821987326388 1.1169799101353364 1.0 9.074671296915618 -8.024954305615507 3.866928371663293 1.0519245704727866 0.7345185884554223 0.5443657803099331 0.12022167182966491 0.19190551526360006 6.160446474139655 0.09305553743093628 0.03499670416619062 9.441602110735949e-09 8.024954305615507 -0.31740598201736436 SEANDAVNS(ph)STK ddPTM_A459_Selumetinib_30min_R1 2 SEANDAVNSSTK 12 0 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 SEANDAVNS(0.333)S(0.333)T(0.333)K;SEANDAVNS(0.95)S(0.048)T(0.003)K 206.67 1.0085e-05 31747000.0 11388.2 11864.4 7422.9 7422.700000000001 8645.7 7705.9 10102.7 10032.2 5694.7 9927.599999999999 True False 11653.522902420236 10475.310532390084 6414.910951071087 6126.464786335668 7863.697961522307 7628.3856423973875 9340.645205269566 9766.113466821795 9663.489975568193 11201.904163012929 1.0403162473839482 0.935136596417067 0.5726625453779722 0.5469128013578594 0.7019965397925028 0.6809900827026548 0.8338444133552784 0.8718261935384247 0.8626649393659019 1.0 13.45145637013916 -8.06710563573559 1.1385916696536293 0.9717554650012584 0.7393522282614191 0.21660770886819736 0.1442279878554161 0.8017327273948802 1.928656536190417 0.14847459129714047 0.051310997494483285 8.568294087492151e-09 8.06710563573559 -0.23240323673983931 SEANDAVNS(ph)STK ddPTM_A459_Selumetinib_30min_R2 1 SEANDAVNSSTK 12 0 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 SEANDAVNS(0.948)S(0.049)T(0.003)K 105.14 0.0094489 32384000.0 60808.0 41468.0 45186.0 55684.0 51104.0 46218.0 61152.0 63306.0 61555.0 39606.0 True False 57428.53479371067 44648.46225936423 42278.78195479692 48099.74313974211 44683.85864444339 52584.10997476866 63995.68917038917 63490.20997912748 73867.7199904021 38462.47187125376 1.4931056689737054 1.1608318469186527 1.0992216541962663 1.250562972154972 1.161752130596666 1.3671536803662687 1.6638475390922165 1.6507053990614435 1.9205141114606745 1.0 15.23116386302299 -7.076861213287666 3.6014273434845365 1.6114053003379412 1.223980394189739 0.2802116233663442 0.23914100458037954 0.26219108180069856 6.506321893005397 0.09080077948805416 0.07055120673558123 8.377969726349312e-08 7.076861213287666 -0.38742490614820224 SEANDAVNS(ph)STKEEK ddPTM_A459_Selumetinib_30min_R1 1 SEANDAVNSSTKEEK 15 1 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 SEANDAVNS(0.921)S(0.06)T(0.019)KEEK 76.118 0.02056 20102000.0 4462.0 4898.2 3356.1 4174.0 3062.2 3920.0 4398.4 3743.7 2569.3 4046.2 True False 4565.95591845938 4324.716466888596 2900.3600537377124 3445.089255683922 2785.2245506753193 3880.568359075226 4066.6251468278433 3644.404914748586 4359.914445752608 4565.5691833255705 1.000084706882818 0.9472458511160844 0.6352680109044112 0.7545804514946616 0.6100497963862976 0.8499637620754684 0.8907159181115956 0.7982367079352839 0.9549552904982676 1.0 12.15657901492037 -8.319130867388095 1.1378714167836597 1.0039266193923102 0.795391642179304 0.23546388669529938 0.11805033413950472 0.7354206128642001 1.9747896813009598 0.12018833066329755 0.03925596867962425 4.7958891075306885e-09 8.319130867388095 -0.20853497721300618 SEANDAVNS(ph)STKEEK ddPTM_A459_Selumetinib_30min_R2 1 SEANDAVNSSTKEEK 15 1 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 SEANDAVNS(0.695)S(0.228)T(0.077)KEEK 59.342 0.048222 10440000.0 23790.0 19782.0 23567.0 19313.0 18063.0 15925.0 23698.0 27380.0 14291.0 19452.0 True False 22467.847038915566 21299.2157908446 22050.724877809487 16682.53608321672 15793.76445473115 18118.52419724331 24800.003956696142 27459.671266996993 17149.59932390278 18890.370217634405 1.1893809798360404 1.1275171182702128 1.1672997735758959 0.8831238292854291 0.8360749033911187 0.9591407679416168 1.312838428838468 1.4536333036693496 0.9078487677225833 1.0 14.205363355807831 -10.542921986422158 14.253811653245153 0.9999999733172492 1.095594168899014 0.021184424828087245 0.18886650987645 0.0 0.0 0.19907040734573794 0.04828166567183597 2.864692516718798e-11 10.542921986422158 0.09559419558176485 SEANDAVNSS(ph)TK ddPTM_A459_Selumetinib_30min_R2 1 SEANDAVNSSTK 12 0 O15234;J3KSY7;K7EQ38 O15234 CASC3 Protein CASC3 1 SEANDAVNS(0.047)S(0.889)T(0.064)K 149.35 0.00057855 33260000.0 79774.0 57030.0 70545.0 66957.0 77698.0 64147.0 89783.0 76598.0 65791.0 60212.0 True False 75340.4804406242 61404.01761964749 66006.21150358848 57837.3410927325 67936.88261106692 72982.6669815112 93958.08740163947 76820.8874985185 78951.03835413115 58473.52311043609 1.2884546104453518 1.0501166058299023 1.1288222086246757 0.9891201695423404 1.161840077307431 1.2481318569375819 1.6068484059731687 1.3137721726366758 1.3502014955558634 1.0 15.835495897851692 -6.84485334572549 3.472567332984114 1.3519919054705007 1.110146975794404 0.24096667340679445 0.15651617355450895 0.27040621023236056 6.442262066186979 0.0554541221160402 0.04931410979559914 1.4293765545397533e-07 6.84485334572549 -0.24184492967609672 SEAPAEVTHFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 SEAPAEVTHFSPK 13 0 Q6PID6 Q6PID6 TTC33 Tetratricopeptide repeat protein 33 1 SEAPAEVTHFS(1)PK;SEAPAEVT(0.013)HFS(0.987)PK;SEAPAEVT(0.016)HFS(0.984)PK;SEAPAEVTHFS(1)PK 148.41 0.00036193 164619000.0 36168.8 39355.2 43618.6 44597.600000000006 34923.9 35631.1 36934.9 34971.7 22062.1 32646.7 True False 37011.462667766384 34747.47488826387 37695.43369981938 36809.466360634724 31765.03941131532 35272.68348445031 34148.87075654143 34044.136911908834 37437.77234796972 36837.22195078716 1.0047300178393472 0.9432707747257624 1.0232974069048624 0.9992465341118959 0.8623082232898006 0.9575283264186696 0.9270207944063413 0.924177641771962 1.0163028145277857 1.0 15.168876645404747 SEAPAEVTHFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 SEAPAEVTHFSPK 13 0 Q6PID6 Q6PID6 TTC33 Tetratricopeptide repeat protein 33 1 SEAPAEVT(0.061)HFS(0.939)PK;SEAPAEVT(0.001)HFS(0.999)PK;SEAPAEVT(0.044)HFS(0.956)PK 117.18 0.0024259 182150000.0 1448404.0 1205345.0 1337478.0 1352695.0 1251700.0 972998.0 1108408.0 1136328.0 771709.0 1145949.0 True False 1367907.5041006077 1297791.085704966 1251426.121615941 1168455.607470968 1094450.2556600228 1107019.642503569 1159951.1682687858 1139634.526350773 926072.3633510381 1112862.4748369271 1.2291792876752838 1.1661738220575164 1.1245110244186445 1.049955078808985 0.9834550812942072 0.9947497265246414 1.0423131289773777 1.024056927175812 0.8321534639639455 1.0 20.085843887853457 -4.978244469445015 0.5253555889935971 0.9627012177686087 1.3840806130900325 0.7439008032088597 0.052843634333784376 1.8625001528586647 0.4566742340767256 0.033318569833235716 0.4710839912867647 1.051369878812811e-05 4.978244469445015 0.42137939532142377 SECDS(ph)SPEPK ddPTM_A459_Selumetinib_30min_R1 3 SECDSSPEPK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SECDS(0.5)S(0.5)PEPK;SECDS(0.5)S(0.5)PEPK;SECDS(0.5)S(0.5)PEPK 205.52 8.378799999999999e-05 138424000.0 28601.6 31803.7 31463.0 32244.9 25923.2 28636.0 26345.4 27142.8 18673.9 25245.4 True False 29267.96163097439 28080.108018861 27190.497413888035 26613.93352673757 23578.45113711268 28347.947839407694 24358.14526719676 26422.88477176 31688.24441230669 28485.89300102006 1.027454594101239 0.9857548793662698 0.9545250139398601 0.9342846835022706 0.82772378370825 0.9951574218997654 0.8550950207642959 0.9275778986747516 1.1124188527694026 1.0 14.7979600133497 -8.246722008643438 24.885290598737406 1.0562094252985994 0.9358420180349094 0.3599975182546701 0.06273028208149949 700.6750965785665 1184762.5022099577 0.04323303105346651 0.01616836362706073 5.66601854127758e-09 8.246722008643438 -0.12036740726369 SECDS(ph)SPEPK ddPTM_A459_Selumetinib_30min_R2 2 SECDSSPEPK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SECDS(0.5)S(0.5)PEPK;SECDS(0.5)S(0.5)PEPK 155.33 0.00052713 113914000.0 355800.0 314750.0 298420.0 331200.0 300270.0 267030.0 320850.0 354780.0 265670.0 331900.0 True False 336026.0603802505 338890.3129192361 279219.98209512926 286089.9886481328 262547.3981521409 303810.9586430063 335770.1607522135 355812.35106300906 318811.4234400142 322317.1846202375 1.0425322521235258 1.051418692796431 0.8662894670791863 0.8876038954770951 0.8145622097732117 0.9425838060758822 1.0417383148460628 1.1039198902231553 0.9891232570042646 1.0 18.29812158342216 -7.238966843076442 5.51444514265809 1.0427776480655608 0.9282784275763346 0.29735761971462293 0.07428503619760765 0.23254459058490387 23.34175412169502 0.03275112427534859 0.024245085252177292 5.76810499253566e-08 7.238966843076442 -0.11449922048922623 SECDSS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 1 SECDSSPEPK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SECDS(0.12)S(0.88)PEPK 201.09 0.00020622 35279000.0 15542.0 17351.0 17389.0 17113.0 14337.0 15595.0 14393.0 14884.0 10355.0 13566.0 True False 15904.098360532425 15319.536853738944 15027.669310939802 14124.535800795156 13040.220881402942 15438.128459127083 13307.324422129223 14489.22796995431 17571.678700723245 15307.328244030137 1.0389859096890426 1.0007975663364748 0.9817303889593272 0.9227303142404181 0.85189398656089 1.0085449408944345 0.8693433765829829 0.9465549924171198 1.147925909773066 1.0 13.901934874963555 -8.238384310725838 24.351757888559245 1.073962945876988 0.9498928211620323 0.3548289919995884 0.06539460353898321 526.5114401695605 556125.9532466985 0.04460814037169724 0.016835604157434927 5.7758471177871434e-09 8.238384310725838 -0.1240701247149556 SECFS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 SECFSSPK 8 0 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 SECFS(0.699)S(0.301)PK;SECFS(0.5)S(0.5)PK 97.565 0.020166 18195200.0 169233.0 159934.0 146853.0 155357.0 150315.0 128176.0 163362.0 132764.0 111447.0 141904.0 True False 159827.7073533751 172200.42353113665 137404.63786145698 134197.10859422694 131431.08586685016 145831.0805341199 170958.65669566198 133150.32125973664 133739.5140893563 137806.86280912967 1.1597949775167986 1.2495779964866047 0.9970812415327255 0.9738057006645421 0.9537339664200155 1.05822799794887 1.2405670748956052 0.96620965418941 0.9704851511973908 1.0 17.072288210767546 -5.264914008260774 24.90706082989243 1.0240313094234135 1.2046864932251462 0.44802999935474097 0.08189403354759073 258.9215223367921 1856032.839342431 0.0229588664810192 0.051056185977195974 5.433579074989403e-06 5.264914008260774 0.18065518380173273 SECQDMSLSS(ph)PTSVLGGSR ddPTM_A459_Selumetinib_30min_R1 1 SECQDMSLSSPTSVLGGSR 19 0 O95613-2;O95613 O95613-2 PCNT Pericentrin 1 SECQDMS(0.004)LS(0.104)S(0.891)PTSVLGGSR 145.99 4.8264e-05 4838600.0 1362.2 1562.3 1916.1 2394.3 1925.2 1532.0 1630.4 1594.7 974.99 1484.6 True False 1393.9366096202084 1379.3851897064337 1655.904144383907 1976.1804515773879 1751.065999921666 1516.5894709447052 1507.4176153574301 1552.4033756843685 1654.4868195478668 1675.162871228596 0.832120048480939 0.8234334782592015 0.9885033705226738 1.1796945153924168 1.0453108948369905 0.905338517819709 0.899863315530544 0.9267178746301884 0.9876572887115359 1.0 10.710085656107442 -5.263158742529379 22.046649152831975 0.9912922538377847 0.8277766889546068 0.4235561605783391 0.07646248501303922 29.696667641203906 380834.2905911525 0.0228242744422565 0.05196674252255586 5.455584131233467e-06 5.263158742529379 -0.16351556488317798 SECQDMSLSS(ph)PTSVLGGSR ddPTM_A459_Selumetinib_30min_R2 2 SECQDMSLSSPTSVLGGSR 19 0 O95613-2;O95613 O95613-2 PCNT Pericentrin 1 SECQDMS(0.004)LS(0.063)S(0.928)PT(0.003)S(0.001)VLGGSR;SECQDMS(0.003)LS(0.082)S(0.915)PTSVLGGSR 133.94 0.00021651 12107400.0 58319.0 55080.0 68181.0 72076.0 77407.0 55168.0 60390.0 56064.0 52936.0 68145.0 True False 55077.86344945428 59304.458889885784 63794.30868985996 62259.124461964864 67682.44063263989 62766.89123475789 63198.25466051485 56227.13695810517 63524.67915542073 66177.47678802676 0.8322750597741029 0.896142642002566 0.9639882296237988 0.9407902429007262 1.0227413300968498 0.9484630463595141 0.9549813279062503 0.8496415954057368 0.959913889719561 1.0 16.014052665234395 -4.932303306897597 2.496980769719104 0.951365677399535 0.8239403772959173 0.45026007177039606 0.0427930367446414 0.3747777277683736 3.780346523185397 0.01176426954375795 0.08971076382958428 1.1686829095535739e-05 4.932303306897597 -0.12742530010361774 SEDDSAKFDS(ph)NEEDSASVFSPSFGLK ddPTM_A459_Selumetinib_30min_R1 2 SEDDSAKFDSNEEDSASVFSPSFGLK 26 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 S(0.001)EDDS(0.005)AKFDS(0.824)NEEDS(0.159)AS(0.009)VFS(0.003)PSFGLK;S(0.001)EDDS(0.011)AKFDS(0.988)NEEDSASVFSPSFGLK 97.542 1.763e-06 155812000.0 4199.4 5799.5 7228.5 7351.6 5168.3 5461.6 4965.5 4603.5 2869.2 3908.0 True False 4297.23784939003 5120.491843885596 6246.909403308321 6067.781066623371 4700.828177537475 5406.661262736033 4590.948337253014 4481.40022572458 4868.822841923242 4409.629867143573 0.974512142483662 1.161206722142078 1.4166516445868693 1.3760295647112664 1.0660369054018883 1.226103193608471 1.0411187504557822 1.0162758237637521 1.1041341311208779 1.0 12.106441849459253 -7.149187542213412 1.609032959633608 1.0358624748343945 1.2240621949989872 0.26950003897025077 0.1264557722043714 0.5520476289092947 2.8223649288621653 0.07179869946924701 0.04769691647202449 7.09271415795248e-08 7.149187542213412 0.18819972016459263 SEDDSAKFDS(ph)NEEDSASVFSPSFGLK ddPTM_A459_Selumetinib_30min_R2 4 SEDDSAKFDSNEEDSASVFSPSFGLK 26 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 SEDDS(0.001)AKFDS(0.997)NEEDS(0.001)AS(0.001)VFSPSFGLK;SEDDS(0.002)AKFDS(0.724)NEEDS(0.21)AS(0.061)VFS(0.003)PSFGLK;SEDDS(0.006)AKFDS(0.983)NEEDS(0.007)AS(0.003)VFSPSFGLK;S(0.021)EDDS(0.16)AKFDS(0.811)NEEDS(0.006)AS(0.001)VFSPSFGLK 99.6 1.2483e-06 145595400.0 199736.6 178234.9 180605.9 168400.8 160139.0 126659.4 149429.5 167311.5 101298.4 160874.7 True False 188636.03938096107 191904.94371446804 168985.91302283626 145464.32053241666 140020.90715917575 144105.58265044403 156378.26783893682 167798.34876508993 121560.91051378046 156229.8294083315 1.2074265208850148 1.2283502096958319 1.0816494754094923 0.9310918477176501 0.8962495042685404 0.9223948025559265 1.0009501286096738 1.0740480828825734 0.7780902723516498 1.0 17.25331041210901 -5.512496308413299 2.8000035037969195 0.9459205029700564 1.2178123622959476 0.6897753111962144 0.07402849803508281 0.14909747218574593 2.335288976926291 0.020724442499714706 0.046163965322257985 3.0725834827075427e-06 5.512496308413299 0.2718918593258912 SEDDSAKFDSNEEDS(ph)ASVFSPSFGLK ddPTM_A459_Selumetinib_30min_R1 2 SEDDSAKFDSNEEDSASVFSPSFGLK 26 1 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 SEDDS(0.004)AKFDS(0.32)NEEDS(0.611)AS(0.056)VFS(0.008)PSFGLK;SEDDS(0.003)AKFDS(0.353)NEEDS(0.556)AS(0.083)VFS(0.004)PSFGLK 79.025 8.6067e-05 121364000.0 5612.3 6702.0 7897.2 9418.9 6272.0 7008.9 6154.0 6125.0 3832.6000000000004 5422.4 True False 5743.055670365213 5917.326724324727 6824.8036162145 7774.065929650529 5704.698707411535 6938.396829572022 5689.798825386175 5962.545103196053 6503.642277971213 6118.417858648754 0.9386504490285925 0.9671334748672368 1.1154523561294898 1.2706006861988701 0.932381350735566 1.1340181383270804 0.9299460999289709 0.9745240094655572 1.0629614433374994 1.0 12.578942924087501 -7.267557451107867 24.65899347389458 0.9897348958932141 1.061830783049646 0.09750453470322473 0.10091722747215821 1075.7943796642037 4335990.067515652 0.043253402072418394 0.030043267885528396 5.400606675386761e-08 7.267557451107867 0.072095887156432 SEDES(ph)ET(ph)EDEEEKSQEDQEQK ddPTM_A459_Selumetinib_30min_R2 2 SEDESETEDEEEKSQEDQEQK 21 1 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 2 S(0.033)EDES(0.983)ET(0.976)EDEEEKS(0.007)QEDQEQK;SEDES(1)ET(1)EDEEEKSQEDQEQK 93.381 0.0017535999999999995 24107000.0 116012.0 94166.0 88644.0 82716.0 75698.0 76908.0 96144.0 89759.0 58694.0 78861.0 True False 109564.51747283201 101388.2294085871 82940.7415482896 71449.93810694125 66188.14049129379 87501.3788986869 100614.88650572186 90020.18382959768 70434.4400473829 76584.07802451501 1.4306435527990526 1.3238813082809737 1.0830024162690812 0.9329607400126918 0.8642545839633479 1.142553141015515 1.3137833489816833 1.1754425482641666 0.919700829000467 1.0 16.22475686383129 -5.179845879056327 3.1496721431417005 1.0599224515820944 1.4114015914206923 0.5135579626364608 0.12774274712223435 0.23843541744671887 4.498582670170445 0.0380839327384808 0.12644812387185148 6.609279542516827e-06 5.179845879056327 0.3514791398385979 SEDES(ph)ETEDEEEK ddPTM_A459_Selumetinib_30min_R2 1 SEDESETEDEEEK 13 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 SEDES(0.947)ET(0.053)EDEEEK 286.26 1.2655999999999993e-49 5067400.0 18254.0 12488.0 17385.0 16597.0 21770.0 12279.0 21935.0 24085.0 17437.0 11510.0 True False 17239.515756551697 13445.78944475115 16266.468027356803 14336.459968578054 19035.057973730673 13970.320792335993 22955.020963377938 24155.083362513597 20924.887230487202 11177.676393428543 1.5423165915491135 1.2029145388979101 1.4552638182404356 1.2825975152587696 1.702953038157515 1.2498412282314124 2.0536487330115767 2.1610111540458075 1.872024783504122 1.0 13.448332692588727 -7.259314610468503 24.996208322572336 1.8684221010947808 1.4068813189686113 0.210369057549038 0.3262115601165302 224.18935615906565 2637431.434326204 0.12184671326921713 0.08969221393703054 5.5040882623159775e-08 7.259314610468503 -0.46154078212616945 SEDES(ph)ETEDEEEKSQEDQEQK ddPTM_A459_Selumetinib_30min_R1 2 SEDESETEDEEEKSQEDQEQK 21 1 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 S(0.001)EDES(0.832)ET(0.166)EDEEEKSQEDQEQK;S(0.002)EDES(0.938)ET(0.06)EDEEEKSQEDQEQK 108.5 6.8081e-05 45185000.0 2704.9 2845.3999999999996 3479.2 3953.6000000000004 2506.37 2460.0 2497.1 2523.0 1518.83 2988.8 True False 2767.918907180812 2512.259245209428 3006.7437498776108 3263.1779782635285 2279.6692760355645 2435.254633501288 2308.7417365732567 2456.0818441410033 2577.343579045823 3372.441593377359 0.8207462844178888 0.7449378071195907 0.8915628830406171 0.967601035603286 0.6759699798840908 0.7221043170276176 0.684590577078356 0.7282800238747323 0.7642366836262156 1.0 11.719577742313168 -4.4513869123462175 18.54843580713166 0.7874600211814222 1.5266170608526908 0.0 0.11026998161654263 33706215.21954494 113523262.75916436 0.02820816591607362 1002919568.1599215 3.536821057898046e-05 4.4513869123462175 0.7391570396712686 SEDES(ph)ETEDEEEKSQEDQEQK ddPTM_A459_Selumetinib_30min_R2 2 SEDESETEDEEEKSQEDQEQK 21 1 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 S(0.001)EDES(0.959)ET(0.04)EDEEEKSQEDQEQK;S(0.003)EDES(0.965)ET(0.032)EDEEEKSQEDQEQK 81.723 0.00094355 143456000.0 103182.0 86577.0 85642.0 73764.0 80461.0 47469.0 92582.0 80731.0 54384.0 68068.0 True False 97447.55751027253 93217.17751106809 80131.8869599591 63717.21595000253 70352.76984953355 54007.42386932134 96887.24644775256 80965.91384426341 65262.31961592107 66102.69997809677 1.4741842245863166 1.4101871412507467 1.2122331914809972 0.9639124569966934 1.064294951232628 0.8170229640728257 1.4657078527784235 1.2248503294281714 0.9872867467977229 1.0 16.012421579655467 -5.344382739390993 2.8892242908773973 1.0890757652501435 1.4563723618020012 0.4360990154401706 0.1649202034060311 0.26786136132332694 4.289513895253391 0.04719499551307676 0.1251220200599752 4.524986216128902e-06 5.344382739390993 0.36729659655185776 SEDES(ph)ETEDEEEKSQEDQEQKR ddPTM_A459_Selumetinib_30min_R1 2 SEDESETEDEEEKSQEDQEQKR 22 2 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 S(0.008)EDES(0.789)ET(0.202)EDEEEKS(0.001)QEDQEQKR;S(0.034)EDES(0.868)ET(0.097)EDEEEKSQEDQEQKR 68.303 0.0020743000000000003 59553000.0 6067.3 4303.9 7329.5 7756.4 4797.2 4656.3 4454.4 4622.5 2773.9 4704.9 True False 6208.656285089334 3799.997387171173 6334.19415806161 6401.890345660466 4363.294107014451 4609.461849582135 4118.401021741984 4499.896284003879 4707.10570235985 5308.819744606909 1.1694984165541777 0.7157894918228277 1.1931454565765494 1.2058971021127585 0.8218953207908419 0.8682649009254395 0.775765842478596 0.8476264971277667 0.8866576619297868 1.0 12.374175441761972 -6.285311917026527 24.898461175419193 0.8546143809951696 1.0544233265242025 0.32968756938845645 0.14134703791801503 913.5097599374582 952765.2454555079 0.044220511460760184 0.050166967099450364 5.184275624771109e-07 6.285311917026527 0.19980894552903283 SEDESET(ph)EDEEEK ddPTM_A459_Selumetinib_30min_R2 1 SEDESETEDEEEK 13 0 J3KQ69;A0A499FHX9;P25205;P25205-2;Q7Z6P5 J3KQ69 MCM3 DNA replication licensing factor MCM3 1 SEDES(0.071)ET(0.929)EDEEEK 244.71 5.1866999999999995e-18 4581100.0 27139.0 16793.0 21686.0 20711.0 25159.0 15960.0 33834.0 29523.0 24216.0 17107.0 True False 25630.72302602478 18080.9691019944 20290.746369931538 17890.126071532202 21998.301495686264 18158.34512954495 35407.34804079912 29608.90704220423 29059.876651573002 16613.076460676104 1.542804133039046 1.0883576648065676 1.221371996809901 1.0768701458684629 1.324155796655558 1.0930152023634252 2.1312938711026765 1.782265139890847 1.7492170532266573 1.0 14.02003164030174 -7.240500774209324 24.996114303425028 1.7308828212682408 1.215930906925377 0.34167807203670353 0.29441545293355975 750.2240844305097 895604.5753710647 0.10571594150050388 0.08180414694352052 5.747767941998751e-08 7.240500774209324 -0.5149519143428638 SEDFGVNEDLADSDAR ddPTM_A459_Selumetinib_30min_R1 2 SEDFGVNEDLADSDAR 16 0 P04083 P04083 ANXA1 Annexin A1 0 ; 444.59 0.0 177388000.0 3431.4 4368.5 3276.1 3438.6 3828.1 3218.9 4100.299999999999 3745.7 2006.1999999999998 3354.2999999999997 False True 3511.3449436578912 3857.0339891394465 2831.2236143291675 2838.113060516231 3481.8490309059475 3186.520788527359 3791.011069829532 3646.351868251666 3404.374872949393 3784.857078648848 0.9277351484329766 1.0190699170380206 0.748039768872827 0.7498600347491604 0.9199420106370116 0.8419131085565089 1.001625950743398 0.963405431825017 0.8994725037714547 1.0 11.886023107774669 -7.256274955663974 24.929408836392042 0.9630764251463899 0.8662087117830933 0.2627154586710755 0.08063838720448961 654.862802517226 3161124.3584360415 0.03404898500468822 0.025525066315664053 5.542746856620271e-08 7.256274955663974 -0.09686771336329658 SEDFGVNEDLADSDAR ddPTM_A459_Selumetinib_30min_R2 7 SEDFGVNEDLADSDAR 16 0 P04083 P04083 ANXA1 Annexin A1 0 ;;;;;; 281.6 1.590499999999999e-61 311138200.0 215366.7 191510.2 246006.0 246409.0 257203.8 196460.19999999998 205209.69999999998 206743.6 203524.6 192098.59999999998 False True 203397.4809952087 206198.4165376509 230178.24179108132 212847.66912076523 224891.5592128541 223520.8092618689 214752.35766530642 207345.18964775477 244235.2069524585 186552.21428589706 1.090297865258762 1.105312082876944 1.2338542465024083 1.1409549328348876 1.205515357047442 1.1981675485197743 1.1511648815713962 1.1114592793307285 1.3092056177803415 1.0 17.509219958795867 -11.891444969956313 2.087081295453594 3.230623841462241e-05 1.170124230084682 0.3947990501545595 0.06377215728453571 1384107.4871192204 175646.10831504106 6518255.595386148 0.015691519427323393 1.2839704538055142e-12 11.891444969956313 1.1700919238462673 SEDGYHS(ph)DGDYGEHDYR ddPTM_A459_Selumetinib_30min_R1 2 SEDGYHSDGDYGEHDYR 17 0 P52756;C9JR02;C9J9P7;C9JFQ5;P52756-4;P52756-2;P52756-5 P52756 RBM5 RNA-binding protein 5 1 SEDGY(0.001)HS(0.999)DGDYGEHDYR;SEDGY(0.002)HS(0.998)DGDYGEHDYR 139.2 0.00033539 34119000.0 5398.8 8085.299999999999 4498.7 4337.5 6114.8 5398.4 6840.200000000001 5999.799999999999 2725.3 6122.9 True False 5524.581535763895 7138.669317246003 3887.8012495902562 3580.0370499590376 5561.7174196556225 5344.096997355023 6324.238206923387 5840.665813902972 4624.635051963406 6908.833857096572 0.7996402359696624 1.03326689639719 0.5627290118717806 0.5181825361572009 0.8050153665141004 0.7735165019007814 0.9153843235681948 0.845390978378152 0.669379977521547 1.0 12.754226503153907 -6.85084257560491 2.69802551308684 0.8430365917084544 0.7351546418263087 0.10478927860587406 0.15335128611546364 0.7724669798466322 11.420557134777784 0.06333087258437288 0.05572370298542816 1.4097997343427879e-07 6.85084257560491 -0.10788194988214561 SEDGYHS(ph)DGDYGEHDYR ddPTM_A459_Selumetinib_30min_R2 1 SEDGYHSDGDYGEHDYR 17 0 P52756;C9JR02;C9J9P7;C9JFQ5;P52756-4;P52756-2;P52756-5 P52756 RBM5 RNA-binding protein 5 1 SEDGYHS(0.999)DGDYGEHDYR 82.189 0.0096915 18350000.0 55464.0 40417.0 77226.0 70048.0 73742.0 60316.0 64483.0 67108.0 58186.0 58409.0 True False 52381.53291998374 43516.85393886188 72257.36323731142 60507.341560460045 64477.87069815555 68623.98150586669 67481.58727064056 67303.27316967251 69824.82585267696 56722.58040519266 0.9234687940111498 0.7671874873816237 1.2738729923982202 1.0667240652352428 1.136723157472098 1.2098176954513957 1.1896776696086797 1.1865340520282686 1.2309881770873186 1.0 15.791635544233664 -5.258312769770888 24.999361050396924 1.1668746472031768 0.8453281222552017 0.6977940132680241 0.08325150025511585 129.72213068686236 1037203.9945639272 0.020111937640891496 0.04874864034071977 5.516799878312709e-06 5.258312769770888 -0.3215465249479751 SEDIY(ph)ADPAAYVMR ddPTM_A459_Selumetinib_30min_R2 2 SEDIYADPAAYVMR 14 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 SEDIY(1)ADPAAYVMR;SEDIY(1)ADPAAYVMR 141.71 0.0077191 1297800.0 15984.5 19761.4 19994.9 22850.5 21819.6 14880.3 13524.599999999999 15672.900000000001 12452.2 16928.199999999997 True False 15096.145481023357 21277.035837084033 18708.44990280108 19738.222480688855 19078.42677830105 16929.926255085695 14153.52069848648 15718.505544211723 14942.987943538039 16439.4388812543 0.9182883667785836 1.2942677661185862 1.138022412926399 1.2006627855891188 1.160527857192009 1.0298360167505893 0.8609491358385458 0.9561461104451291 0.9089718968800908 1.0 14.004873436656203 -6.950033585016585 3.532980050027097 0.9283452415604724 1.1533598797351055 0.5236728751702522 0.09435791731631979 0.17136207422746746 4.424497213712416 0.03401005593324489 0.02878672924916682 1.1219316893234845e-07 6.950033585016585 0.22501463817463307 SEDMPFS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 SEDMPFSPK 9 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SEDMPFS(1)PK;SEDMPFS(1)PK;SEDMPFS(1)PK;SEDMPFS(1)PK 143.0 0.0020716 319448000.0 27816.8 33214.0 36330.7 38299.4 28981.6 26616.2 28934.6 28679.1 19714.800000000003 28496.100000000002 True False 28464.877317929357 29325.28943923033 31397.190490250196 31611.12875877836 26360.219397117067 26348.465193576027 26752.039826619886 27918.437105154288 33454.57568797865 32153.85201051948 0.8852711428981126 0.9120303666769458 0.9764674689669612 0.9831210502690763 0.8198152864699706 0.8194497251824087 0.8320010870818111 0.8682765939216387 1.040453121356459 1.0 14.972703961382036 -11.521022455158771 5.880511880135816 1.0968920284586083 0.9006417384423222 0.13726357921627153 0.07165867504810595 0.07118808764615944 2.2471717536898617e-05 0.054261081464298 0.018002413546550963 3.0128502409966303e-12 11.521022455158771 -0.19625029001628613 SEDMPFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 5 SEDMPFSPK 9 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SEDMPFS(1)PK;SEDMPFS(1)PK;SEDMPFS(1)PK;SEDMPFS(1)PK;S(0.003)EDMPFS(0.997)PK 145.23 0.0018742 268848600.0 1786825.0 1677491.0 1655911.0 1643931.0 1564929.0 1142546.0 1519315.0 1493535.0 1002017.0 1454234.0 True False 1687520.419727207 1806149.1657162958 1549371.4890795774 1420024.7618608498 1368328.628377232 1299921.3405000675 1589966.157965557 1497880.93958197 1202448.3986942188 1412246.4858663054 1.194919184870226 1.2789192140268355 1.097097075181714 1.0055077325894517 0.968902130096551 0.9204634980576106 1.1258418228530653 1.0606370450007772 0.8514437180253336 1.0 20.429560480102225 -5.505607823409303 2.862840385022157 0.9946816909136342 1.2366643500492494 0.6457078656560475 0.07259497837636414 0.1661529842710591 2.720630516592311 0.020776459277806532 0.04626029313406075 3.121707275701891e-06 5.505607823409303 0.24198265913561512 SEDPPGQEAGS(ph)EEEGSSASGLAK ddPTM_A459_Selumetinib_30min_R1 1 SEDPPGQEAGSEEEGSSASGLAK 23 0 K7EIG1;I3L2B0;A0A494C0R8;O75153 K7EIG1 CLUH Clustered mitochondria protein homolog 1 SEDPPGQEAGS(1)EEEGSSASGLAK 113.65 7.9543e-06 11288000.0 2883.4 3132.8 3865.7 3433.5 3017.9 3101.9 3081.7 2747.4 1534.5 2236.1 True False 2950.577609880273 2766.0103196007935 3340.7591727701415 2833.9036797773724 2744.9314778535195 3070.697702299857 2849.2448879090966 2674.530027187076 2603.9344245543057 2523.1252164584835 1.1694138644540883 1.096263594671385 1.3240560361325657 1.123172033354375 1.087909335592297 1.2170215264266429 1.129252273855977 1.0600068556807924 1.0320274267676846 1.0 11.30099609013644 -7.825537325522739 1.8934984271877704 1.0146767241176127 1.1685675691977295 0.4920157210932111 0.06405376832058896 0.315526578903109 2.162964210800143 0.04947319697914359 0.01895707566508027 1.494385601589283e-08 7.825537325522739 0.15389084508011686 SEDPPGQEAGS(ph)EEEGSSASGLAK ddPTM_A459_Selumetinib_30min_R2 1 SEDPPGQEAGSEEEGSSASGLAK 23 0 K7EIG1;I3L2B0;A0A494C0R8;O75153 K7EIG1 CLUH Clustered mitochondria protein homolog 1 SEDPPGQEAGS(0.995)EEEGS(0.004)S(0.001)ASGLAK 69.57600000000001 0.0018254 6091100.0 51985.0 52425.0 72186.0 81203.0 99190.0 59697.0 53331.0 61356.0 60792.0 77684.0 True False 49095.88181244325 56445.828927056304 67541.63135017407 70143.01131701187 86728.86543014899 67919.71987458925 55810.99717337171 61534.53580196742 72952.09867040078 75441.06107272815 0.6507846140328394 0.7482109626300233 0.8952900501367721 0.9297723324621754 1.149624146279424 0.9003017575417183 0.7397960259276803 0.8156637105441255 0.9670078553120043 1.0 16.203062347100072 -5.1202083293320495 2.2888826959087907 0.9213082469300398 0.6508109899732306 0.45010599596265843 0.102616438345618 0.37013996293924706 3.4175311984909365 0.031071530962379555 0.1487989558645893 7.582137756533524e-06 5.1202083293320495 -0.27049725695680915 SEDPPTT(ph)PIR ddPTM_A459_Selumetinib_30min_R1 2 SEDPPTTPIR 10 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C151 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SEDPPT(0.006)T(0.994)PIR;SEDPPT(0.035)T(0.964)PIR 169.21 0.00056668 161723000.0 20296.1 24367.0 23334.0 24299.0 24791.0 19896.9 23829.0 23884.0 12931.8 19229.0 True False 20768.959640664154 21514.100312089035 20165.37096448729 20055.635798721527 22548.658427206534 19696.75525093976 22031.559345162026 23250.518733834226 21944.320098697535 21697.229456321336 0.9572171268444258 0.991559791327231 0.9293984287294454 0.9243408629242503 1.0392413682400883 0.9078004770420699 1.0154088746452044 1.071589291187606 1.011388119523445 1.0 14.405223214624328 -7.5023957598790165 23.36014142578128 1.0335930421109336 0.96068431703924 0.40776459161600587 0.039112845230479316 297.7646585148859 339592.58562333445 0.015953601395571778 0.01058749421957288 3.14488116955472e-08 7.5023957598790165 -0.07290872507169366 SEDSIAGSGVEHSTPDT(ph)EPGKEESWVSIK ddPTM_A459_Selumetinib_30min_R2 1 SEDSIAGSGVEHSTPDTEPGKEESWVSIK 29 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 SEDSIAGS(0.003)GVEHS(0.064)T(0.064)PDT(0.653)EPGKEES(0.188)WVS(0.027)IK 46.145 0.0247 5706500.0 21914.0 16118.0 17052.0 22388.0 22731.0 16882.0 22975.0 25560.0 16962.0 22315.0 True False 20696.107608692557 17354.198772461485 15954.89288481382 19338.715778545844 19875.32856228168 19207.34226046226 24043.38302409882 25634.375368314217 20354.873957878306 21670.707968667066 0.9550268333926307 0.8008136511992744 0.7362423464836706 0.8923896628807435 0.9171517880735016 0.8863274004814933 1.1094876576650068 1.1829043797451417 0.9392805249975553 1.0 14.403458665708351 -7.183835416727878 4.683205729472106 1.0729639299452005 0.8567260800242217 0.5617935755815153 0.08322854412265994 0.15885754948165867 6.406452334493216 0.03378599487219182 0.02565586681034026 6.548843065810611e-08 7.183835416727878 -0.21623784992097883 SEEAHAEDSVMDHHFR ddPTM_A459_Selumetinib_30min_R1 5 SEEAHAEDSVMDHHFR 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 ;;;; 159.18 2.2296e-05 35649400.0 12593.02 14280.02 10810.670000000002 11340.33 15098.310000000001 10365.630000000001 14155.39 10282.7 4080.75 8968.36 False True 12886.412864248621 12608.108619798806 9342.640392759657 9359.954249858669 13732.670526323142 10261.36117343901 13087.637535730131 10009.969393083114 6924.734703812306 10119.536365224092 1.2734192950314338 1.2459176156653502 0.9232281060687476 0.9249390398975454 1.3570454248789132 1.0140149511890981 1.2933040668449944 0.9891727280592117 0.6842936725450427 1.0 13.304855572850993 -8.000087170951781 24.99999348060392 0.8403422626069438 1.1372581437505929 0.36925844057537527 0.16091066403093998 3.0308186455143975 869007.5081499197 0.08923887876747891 0.04215238163321113 9.997993016085034e-09 8.000087170951781 0.2969158811436491 SEEAHAEDSVMDHHFR ddPTM_A459_Selumetinib_30min_R2 2 SEEAHAEDSVMDHHFR 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 ; 132.51 0.00021549 55557000.0 86218.0 64191.0 109138.0 117809.0 133577.0 94271.0 94762.0 104387.0 103194.0 102701.0 False True 81426.34871800001 69114.24329340334 102116.17990047004 101763.21096813965 116795.86306646852 107255.97454306573 99168.6207673407 104690.7488878019 123835.68348126979 99735.75528075635 0.8164208361262686 0.6929735790223537 1.0238673143148391 1.0203282732624426 1.1710530765790856 1.0754014369384375 0.9943136289305761 1.049681216060351 1.2416377971237307 1.0 16.605823183257158 -5.360099554564035 4.2521469881825675 1.077425700240894 0.755148605209866 0.7257756847988355 0.07838351837651072 0.10744237837429983 3.3278946565710568 0.020833381847170467 0.04666909743640145 4.364157799377271e-06 5.360099554564035 -0.32227709503102797 SEEDNEIES(ph)EEEVQPK ddPTM_A459_Selumetinib_30min_R1 1 SEEDNEIESEEEVQPK 16 0 P52701-2;P52701;P52701-3;A0A087WWJ1;A0A494C0M1;C9J7Y7 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 SEEDNEIES(1)EEEVQPK 270.99 1.5762e-50 16535000.0 2712.9 2822.1 1760.1 1316.5 1951.4 1848.8 2437.4 2949.8 1566.7 2822.2 True False 2776.1052916155195 2491.687220041304 1521.0880875372457 1086.5979887656647 1774.8962145476517 1830.2027505760902 2253.5449556380017 2871.5617216992196 2658.575472759355 3184.4568605559352 0.8717672787474575 0.7824528103691475 0.47766013299727905 0.3412192522450968 0.5573623045525554 0.5747299557565926 0.7076701159156488 0.9017430122127353 0.8348599428962673 1.0 11.636831612747251 -7.619796161354185 2.4555116500921996 0.9108773648600852 0.5897491485384584 0.48214234874133854 0.1437808019246032 0.29096065430135404 3.521380292555568 0.09481008025370502 0.04706558989836838 2.3999590894952455e-08 7.619796161354185 -0.3211282163216268 SEEDNEIES(ph)EEEVQPK ddPTM_A459_Selumetinib_30min_R2 2 SEEDNEIESEEEVQPK 16 0 P52701-2;P52701;P52701-3;A0A087WWJ1;A0A494C0M1;C9J7Y7 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 SEEDNEIES(1)EEEVQPK;SEEDNEIES(1)EEEVQPK 241.68 1.4138e-21 88845000.0 140035.0 99567.0 127072.0 139834.0 155701.0 137211.0 203932.0 210942.0 181060.0 107727.0 True False 132252.4153045205 107203.4687416352 118896.32586553265 120788.36797289518 136140.44839539903 156110.56977255567 213415.2420835918 211555.80629667183 217277.05923908966 104616.64160164006 1.2641623099326025 1.024726727033021 1.1364953419004489 1.154580821212307 1.301326885580934 1.4922154581007725 2.0399741266426403 2.0222003216489726 2.076888111801932 1.0 16.674752836982414 -6.912115638054374 2.306598497717919 1.8668163181668729 1.1498493796610996 0.46689014885435676 0.30067315599469535 0.22505378762321812 2.434188081700881 0.1166255868701053 0.09772942906374532 1.224290168452048e-07 6.912115638054374 -0.7169669385057733 SEEEFIHINNK ddPTM_A459_Selumetinib_30min_R2 2 SEEEFIHINNK 11 0 Q15046;Q15046-2;J3KRL2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 0 ; 125.68 0.005666 3517800.0 70613.0 75982.0 83797.0 89824.0 101545.0 72637.0 76097.0 81458.0 65162.0 76305.0 False True 66688.61214623567 81809.57507936284 78405.59225127521 77589.81624495707 88788.00927618209 82642.08741696457 79635.66128334486 81695.02929390207 78196.22077840281 74101.8763858007 0.8999584814699031 1.1040148923278692 1.0580783655607833 1.047069521438255 1.1981884077256042 1.1152495921520327 1.0746780671076843 1.1024691044065973 1.055252911158221 1.0 16.177222454040283 -4.758750591658311 24.975716502651174 1.0893979972954793 0.8999582261269446 0.546539766706267 0.05003534292508847 54.49325367525962 506078.94030927576 0.012390513395291248 0.08293627749388155 1.7428074523682567e-05 4.758750591658311 -0.1894397711685346 SEEEQS(ph)SSSVKKDETNVK ddPTM_A459_Selumetinib_30min_R2 1 SEEEQSSSSVKKDETNVK 18 2 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 S(0.001)EEEQS(0.361)S(0.273)S(0.273)S(0.093)VKKDETNVK 67.866 0.032401 6425400.0 13608.0 8242.7 9721.7 11500.0 9137.3 8804.5 11193.0 14700.0 9120.2 8463.9 True False 12851.721837140092 8874.888585542147 9096.216406186639 9933.680161393475 7989.3906855015775 10017.23995570667 11713.496678508736 14742.774566283992 10944.49483967938 8219.525215146808 1.5635601206572305 1.0797325092680103 1.1066595901943677 1.2085467105919754 0.9720014813968643 1.2187127228768715 1.425081908249797 1.7936284858785085 1.331523969232559 1.0 13.004839346508732 -7.244125202356331 4.6367997717718215 1.456015522094549 1.1711146596186615 0.11790515910050114 0.2337061873985612 0.2855813462514142 16.63222442222841 0.09241123747947802 0.06703953115764448 5.6999992383871307e-08 7.244125202356331 -0.28490086247588753 SEEEQSSS(ph)S(ph)MKK ddPTM_A459_Selumetinib_30min_R1 1 SEEEQSSSSMKK 12 1 A0A0G2JNQ3;B2RXH8;O60812 A0A0G2JNQ3;O60812 HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 2 SEEEQS(0.014)S(0.553)S(0.711)S(0.723)MKK 124.48 0.010166 8416500.0 2144.6 2733.0 2619.5 3018.6 2365.6 1879.7 2342.6 2241.6 1204.1 1958.5 True False 2194.5650073348233 2413.019089462771 2263.7862878835385 2491.4581761397935 2151.6318976806006 1860.7919246310457 2165.89579596192 2182.1454862570254 2043.2697560155352 2209.8925524055003 0.9930641220298277 1.0919169290996362 1.0243874913372482 1.1274114542029678 0.9736364310285212 0.8420282346331937 0.9800909974579131 0.9874441559983214 0.9246014037159437 1.0 11.109760510441616 -6.5040694421886185 23.877887139091744 0.9436496866513746 1.0579807963563537 0.5004851089468145 0.05331603997728441 341.76779391424435 433865.2677891809 0.01636554574900132 0.018225828453013508 3.1327847627953875e-07 6.5040694421886185 0.11433110970497906 SEEEQSSSS(ph)VKKDETNVK ddPTM_A459_Selumetinib_30min_R1 1 SEEEQSSSSVKKDETNVK 18 2 B4DY08;G3V4W0;G3V2Q1;P07910;G3V4C1;P07910-2;P07910-4;B2R5W2;G3V2D6;P07910-3;G3V5V7 B4DY08;G3V2Q1 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 SEEEQS(0.144)S(0.104)S(0.098)S(0.654)VKKDETNVK 89.663 0.0068266 15597000.0 2839.1 2277.8 2204.6 2477.1 2256.3 2510.5 2045.7 2616.8 1422.3 2168.7 True False 2905.2455060730654 2011.1141170795088 1905.227429000973 2044.5209859258857 2052.2180633821195 2485.246649351621 1891.3912019974803 2547.393963435665 2413.539219318077 2447.073769926887 1.187232498577216 0.8218444992525077 0.7785737612061842 0.8354962613109008 0.8386416824056084 1.0155993987160732 0.7729195683602096 1.040995982524783 0.9862960606169988 1.0 11.256841878479667 -7.78931640765087 24.991784083771538 1.010234592712494 0.8861952780181521 0.16450866457253044 0.11932287302601924 387.97812406695556 347817.33897548507 0.06438762282589663 0.030941160529196255 1.624364884508955e-08 7.78931640765087 -0.12403931469434193 SEEHS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 SEEHSPPR 8 0 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(0.012)EEHS(0.988)PPR;S(0.031)EEHS(0.969)PPR 83.883 0.025021 9131300.0 34394.0 25429.9 28300.4 32631.0 35969.0 29070.9 44915.0 71769.0 46358.0 65763.0 True False 32482.519170090887 27380.291559983772 26479.58307514574 28186.601508385287 31450.252653060106 33075.15259564463 47003.63649738407 71977.83590800247 55630.895350744155 63864.25131720593 0.5086181784039742 0.4287264157218286 0.4146229311234682 0.4413517880039943 0.4924547302191103 0.5178977583462834 0.7359929150961584 1.127044229337276 0.8710803650454194 1.0 15.96272097301654 -7.439469463962319 2.4671591169873004 0.999829527396961 0.458041017478574 0.9213693035251475 0.06961659011977751 0.06962893801806581 0.8307218524804987 0.0342986052173076 0.019851878850386525 3.63521863533233e-08 7.439469463962319 -0.541788509918387 SEEIS(ph)ESESEETNAPK ddPTM_A459_Selumetinib_30min_R1 1 SEEISESESEETNAPK 16 0 P54259 P54259 ATN1 Atrophin-1 1 SEEIS(0.885)ES(0.115)ESEETNAPK 277.0 2.1602999999999998e-62 13457000.0 2375.1 2310.7 2382.3 2871.9 2660.1 2099.9 2259.0 2036.1 1309.1 1976.8 True False 2430.4352088598985 2040.162169784714 2058.7967450372016 2370.3765772397373 2419.4944246787995 2078.7769125566488 2088.6018112686656 1982.0960138150997 2221.4470871189583 2230.541535662596 1.0896166558664522 0.9146488138265811 0.9230030968356855 1.062691072702039 1.0847116657525384 0.9319606379529425 0.9363653524829941 0.8886165005783253 0.995922762074486 1.0 11.123178297932292 SEEIS(ph)ESESEETNAPK ddPTM_A459_Selumetinib_30min_R2 2 SEEISESESEETNAPK 16 0 P54259 P54259 ATN1 Atrophin-1 1 S(0.013)EEIS(0.941)ES(0.045)ESEETNAPK;SEEIS(0.865)ES(0.135)ESEETNAPK 270.79 1.6314999999999995e-50 50644000.0 147234.0 143577.0 148994.0 151911.0 153990.0 109484.0 123641.0 121733.0 103268.0 141587.0 True False 139051.32370440062 154588.89422718127 139407.88825240158 131220.4597389083 134644.39951193336 124564.4272032015 129390.55148999371 122087.22287601684 123924.48554900214 137499.01542279468 1.0112895956151595 1.1242909176610252 1.0138828108967712 0.9543374498749646 0.9792390083515603 0.9059295938969402 0.9410289309500267 0.8879134334206813 0.9012754394491312 1.0 17.069061762530566 -5.7516716302334565 1.6329699734410288 0.9277528926297668 1.070898645877618 0.6067056214226025 0.042085963268335275 0.23156734319112127 1.2515852642840986 0.0130573695958352 0.028767815106682505 1.7714478426148028e-06 5.7516716302334565 0.14314575324785117 SEEKIS(ph)DSEGFK ddPTM_A459_Selumetinib_30min_R2 2 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 SEEKIS(0.899)DS(0.101)EGFK;SEEKIS(0.841)DS(0.159)EGFK 136.6 0.0066141 13102900.0 48881.0 41780.0 42047.0 40502.0 39964.0 27810.2 41930.0 38609.0 26285.4 41133.0 True False 46164.38970614677 44984.39165612616 39341.74179731217 34985.55773015294 34943.36503730696 31640.802614139768 43879.8280827188 38721.345797935974 31543.214475440054 39945.38341363127 1.1556877356293764 1.1261474496393327 0.9848883258906682 0.8758348209574125 0.8747785614039848 0.7921016125068013 1.0984956040688523 0.9693572195059317 0.789658573277732 1.0 15.285741156516961 -5.341682919978263 2.722304094474818 0.9142804298970237 1.151188350966535 0.5057513728317771 0.08850647265643721 0.2316190280570175 3.2923030425411914 0.02507723605169192 0.069027187382311 4.553203699260205e-06 5.341682919978263 0.2369079210695113 SEEKISDS(ph)EGFK ddPTM_A459_Selumetinib_30min_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 SEEKIS(0.029)DS(0.971)EGFK 116.9 0.02325 14102000.0 2216.3 2208.7 2641.8 2576.9 1984.4 2358.9 2002.3 2411.4 1373.7 2257.3 True False 2267.9354778309103 1950.1043772032278 2283.0580703686683 2126.8927894039057 1804.9113703742764 2335.1716077098336 1851.2648989390223 2347.4418386688944 2331.0685689216343 2547.0464429639687 0.8904177951273397 0.7656336155904223 0.8963551005029574 0.835042798406481 0.7086291556874487 0.9168154802047587 0.7268280890805927 0.9216329153139443 0.9152045795478297 1.0 11.314609550682883 -8.21315279415897 1.8239544630319813 0.9846561800512977 0.8215309022621706 0.3882696054901037 0.07084316092057637 0.3346166256859368 2.022806893264083 0.0614180896113323 0.018441077946809693 6.1213499155256785e-09 8.21315279415897 -0.1631252777891271 SEEPAGQILSHLS(ph)SELK ddPTM_A459_Selumetinib_30min_R1 2 SEEPAGQILSHLSSELK 17 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SEEPAGQILS(0.015)HLS(0.768)S(0.217)ELK;SEEPAGQILS(0.001)HLS(0.644)S(0.355)ELK 157.53 2.693e-05 6399000.0 3785.3 3852.7 3477.9 3307.7 3269.5 3164.6 3831.3 3313.2 1789.55 3119.8 True False 3873.4901250883654 3401.624092928364 3005.620282737223 2730.0722882189075 2973.774302277108 3132.7669972269027 3542.301956402672 3225.3231732096606 3036.7356464393342 3520.256719425418 1.1003430811490937 0.9663000070868646 0.8538071289379728 0.775532157400303 0.8447606351739291 0.8899257204566143 1.0062623946871843 0.9162181710815974 0.8626460762597437 1.0 11.781464927824898 -4.872556725885142 2.9425161457098468 0.8890827177522941 1.1154597666172885 0.47471358095692007 0.06626966689770339 0.29827402579984225 4.193957001424496 0.01844511640695817 0.14569305267470437 1.3410447618247036e-05 4.872556725885142 0.22637704886499443 SEEPAGQILSHLS(ph)SELK ddPTM_A459_Selumetinib_30min_R2 1 SEEPAGQILSHLSSELK 17 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SEEPAGQILSHLS(0.774)S(0.226)ELK 107.73 0.0015970999999999995 2789000.0 15039.0 13491.0 15887.0 19076.0 16219.0 12634.0 14858.0 14709.0 9991.6 14326.0 True False 14203.19258588697 14525.716319597836 14864.847716457725 16477.815892064522 14181.424220300323 14374.218819966847 15548.926440568466 14751.800754793956 11990.199188629704 13912.371156581867 1.0209038003681723 1.0440863139800436 1.0684625610656777 1.1844002511584057 1.0193391234815619 1.0331969049838412 1.1176330954348033 1.0603369180396658 0.8618372133464256 1.0 13.764080706281383 -8.181626443303797 7.683615312131425 0.9316263203008359 1.07080070719334 0.4864656153103566 0.05655713917274156 0.2156966153543194 18.334358887210126 0.038337528601442225 0.014327559038913418 6.582237625205106e-09 8.181626443303797 0.13917438689250416 SEERPSS(ph)PDTSTPGSR ddPTM_A459_Selumetinib_30min_R1 1 SEERPSSPDTSTPGSR 16 1 J3KP16;Q9UFD9;A6NNM3;A6NJZ7 J3KP16 RIMBP3C;RIMBP3;RIMBP3B RIMS-binding protein 3A;RIMS-binding protein 3B;RIMS-binding protein 3C 1 SEERPS(0.039)S(0.957)PDT(0.002)S(0.001)T(0.001)PGSR 72.77199999999998 0.020042 4023000.0 1215.0 1104.1 1385.2 1204.8 1207.0 1433.0 1265.3 969.1 821.92 980.98 True False 1243.3071360215483 974.8314587178352 1197.0974483589528 994.4042968969798 1097.8270631131584 1418.585321059898 1169.8574023011263 943.3963199195592 1394.7382093383342 1106.8983385543766 1.1232351632628914 0.8806874351180052 1.0814881608028948 0.898370032965886 0.9918047799646484 1.2815859159320706 1.0568788131247673 0.8522881343842714 1.2600418310862045 1.0 10.112307010667346 -6.577150013038357 24.999998686912082 1.0852745195303335 0.9877271891391176 0.11089748204686012 0.13343096911248029 211.94441431150037 97630.2730661578 0.04306646677917652 0.043066471851378005 2.647585457535584e-07 6.577150013038357 -0.09754733039121588 SEES(ph)PVYSNSSVR ddPTM_A459_Selumetinib_30min_R1 3 SEESPVYSNSSVR 13 0 Q03188;H0Y8J2 Q03188 CENPC Centromere protein C 1 S(0.02)EES(0.976)PVYS(0.002)NS(0.001)S(0.001)VR;S(0.006)EES(0.994)PVYSNSSVR;S(0.003)EES(0.997)PVYSNSSVR 281.54 1.2229999999999999e-48 53292000.0 5686.25 7311.37 6493.4 7743.43 6177.63 5953.25 6203.61 4929.04 3020.05 4841.2 True False 5818.72856148356 6455.351401436305 5611.631945693059 6391.185312683416 5618.864457249162 5893.365710118518 5735.666703144936 4798.30584742163 5124.8042742751595 5462.615177281341 1.0651910069893393 1.18173277668976 1.0272793824158561 1.169986371960437 1.0286033840746556 1.0788542701357842 1.0499854954087189 0.8783898721948179 0.9381594910051297 1.0 12.415376078303392 -7.611281965464399 4.8583354559264675 0.9322732390164468 1.0917427178415298 0.6006582542034749 0.05565927998798557 0.1310330254227098 5.344963862153258 0.0260730215745696 0.014629634667586294 2.447473704879434e-08 7.611281965464399 0.159469478825083 SEES(ph)PVYSNSSVR ddPTM_A459_Selumetinib_30min_R2 1 SEESPVYSNSSVR 13 0 Q03188;H0Y8J2 Q03188 CENPC Centromere protein C 1 S(0.006)EES(0.973)PVYS(0.016)NS(0.005)SVR 142.39 0.00077791 23068000.0 39577.0 25488.0 25401.0 33511.0 26576.0 21215.0 23836.0 31962.0 32074.0 31975.0 True False 37377.46877928377 27442.847643162808 23766.727314517702 28946.743990300587 23237.285287545554 24137.173679404517 24944.421230137967 32055.00412840605 38489.69622243772 31051.79866897286 1.2037134846114907 0.8837764258269477 0.7653897143892523 0.9322082852232435 0.7483394290703161 0.7773196630803395 0.80331646794627 1.0323074830584806 1.2395319392849486 1.0 14.922389218225495 -7.932714285623296 4.846108018313966 1.125689242292446 0.8643985502309598 0.35892224837320064 0.1356324024171311 0.20247122849298288 9.085066082258823 0.0802585875981191 0.036377227479725764 1.1675774922719822e-08 7.932714285623296 -0.26129069206148625 SEESVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SEESVSPK 8 0 F5H212;P15822;C9J2N3 F5H212 HIVEP1 Zinc finger protein 40 1 SEES(0.003)VS(0.997)PK 92.239 0.025743 18573000.0 3747.2 5181.6 3339.5 2972.3 2808.8 3748.7 3454.0 3453.1 2481.6 3586.7 True False 3834.502469218059 4574.935863139513 2886.014242560441 2453.243601981152 2554.744535933918 3710.9914815472703 3193.461999168647 3361.5125707504158 4211.0939511071765 4047.0878824165457 0.9474720047167471 1.1304266168808237 0.7131088640549067 0.6061750259093218 0.6312550184624263 0.9169535204981539 0.7890765142618567 0.8306003399024862 1.0405244643693534 1.0 11.982668462097871 -8.23840732977636 7.077436033297429 1.020745809895246 0.8157459878540273 0.22677229667134136 0.1472547705979267 0.272937411153639 63.21262921746733 0.11940354335522183 0.04187856493824336 5.775540986812202e-09 8.23840732977636 -0.2049998220412187 SEEVPAFGVAS(ph)PPPLTDTPDTTANAEGDLPTTMGGPLPPHLALK ddPTM_A459_Selumetinib_30min_R1 2 SEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALK 44 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 SEEVPAFGVAS(0.78)PPPLT(0.055)DT(0.055)PDT(0.055)T(0.055)ANAEGDLPTTMGGPLPPHLALK;SEEVPAFGVAS(0.748)PPPLT(0.063)DT(0.063)PDT(0.063)T(0.063)ANAEGDLPTTMGGPLPPHLALK 109.62 9.9245e-24 72819000.0 13957.2 17169.2 16430.4 17896.9 17052.8 14783.3 14708.2 15234.6 7664.4 13509.1 True False 14282.375604016408 15159.02208225546 14199.24192572692 14771.542381420608 15510.377250916365 14634.593424162445 13598.748632360244 14830.528919045008 13005.927014372111 15243.1245747772 0.9369716513141575 0.9944825949490104 0.9315178037200067 0.9690626294469232 1.017532670209977 0.9600783194003615 0.892123433463379 0.9729323437784589 0.8532323507932894 1.0 13.895871040024602 -7.019893214922263 23.95925243008738 0.9271427384927613 0.9710688004129779 0.1572754298943171 0.04419500452593274 758.0565051279413 912995.6624004111 0.015710692453215647 0.012356104627813263 9.552274301196123e-08 7.019893214922263 0.04392606192021664 SEEVPAFGVASPPPLTDT(ph)PDTTANAEGDLPTTMGGPLPPHLALK ddPTM_A459_Selumetinib_30min_R1 1 SEEVPAFGVASPPPLTDTPDTTANAEGDLPTTMGGPLPPHLALK 44 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 SEEVPAFGVAS(0.005)PPPLT(0.196)DT(0.567)PDT(0.174)T(0.057)ANAEGDLPT(0.001)TMGGPLPPHLALK 70.561 1.0274e-07 8503100.0 1232.6 1376.8 1640.9 1303.0 1331.7 1461.8 1478.3 1298.7 865.82 1141.8 True False 1261.3171817779087 1215.6036159430446 1418.074792818514 1075.4555103392795 1211.2479701307318 1447.0956192082044 1366.7906408138422 1264.2542572278726 1469.2333030091936 1288.3611520738323 0.9790090144736265 0.9435270645861432 1.1006811176632312 0.834746925276468 0.9401462999571402 1.12320649910847 1.060875390890019 0.9812887133338695 1.1403893237887663 1.0 10.331321349598685 -6.7451987217206035 24.999749392761178 1.0599652499530865 0.9596270029917299 0.31219861219001765 0.07533911713363545 312.31626665024135 480757.33304844564 0.024767665451315684 0.024696387795816194 1.7980479874489475e-07 6.7451987217206035 -0.10033824696135663 SEGDNYSATLLEPAASSLS(ph)PDHK ddPTM_A459_Selumetinib_30min_R2 1 SEGDNYSATLLEPAASSLSPDHK 23 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 SEGDNYSATLLEPAAS(0.097)S(0.097)LS(0.805)PDHK 103.57 1.8637e-05 4292500.0 14699.0 14191.0 15856.0 17331.0 16415.0 11462.0 16261.0 14278.0 11927.0 13632.0 True False 13882.088424759142 15279.40406874309 14835.842222707477 14970.487902357427 14352.800948038084 13040.78645832357 17017.168720560217 14319.546616149852 14312.733268223948 13238.4087398104 1.048622134094793 1.1541722550683173 1.1206665781585434 1.1308374138153279 1.0841787128747955 0.985072051681518 1.2854391381183428 1.081666754486003 1.0811520893128832 1.0 13.69244209979497 -8.634870393034108 2.2731929463829297 1.0006689918643166 1.1140113804168903 0.17300943641574917 0.07354862243210383 0.8080890366382867 8.971363092551531 0.06921664118382032 0.01892286569708015 2.3180863357330732e-09 8.634870393034108 0.11334238855257373 SEGETIMSS(ph)SMGK ddPTM_A459_Selumetinib_30min_R2 1 SEGETIMSSSMGK 13 0 B0YIW6;P48444-2;P48444 B0YIW6 ARCN1 Coatomer subunit delta 1 SEGETIMS(0.002)S(0.499)S(0.499)MGK 176.43 4.8511e-10 0.0 41298.0 32258.0 38523.0 46682.0 43701.0 31794.0 33974.0 42195.0 28367.0 38060.0 True False 39002.82248899264 34732.08487418181 36044.47212067104 40323.83106905827 38210.88968810308 36173.33490280401 35553.858318203864 42317.78046424174 34041.192640203626 36961.108908244125 1.0552395109631876 0.9396927175644036 0.9751999651891226 1.0909800127794351 1.033813400538429 0.9786864077212682 0.9619261804743533 1.1449272414768599 0.92100030669293 1.0 15.173720420730517 SEGETIMSSS(ph)MGK ddPTM_A459_Selumetinib_30min_R2 1 SEGETIMSSSMGK 13 0 B0YIW6;P48444-2;P48444 B0YIW6 ARCN1 Coatomer subunit delta 1 SEGETIMSS(0.006)S(0.994)MGK 212.95 3.8622e-06 5116200.0 34198.0 24822.0 32449.0 33282.0 33922.0 25255.0 28181.0 31632.0 23308.0 23192.0 True False 32297.41206544069 26725.76758469036 30361.2666677999 28748.93418534763 29660.41509347232 28733.64700793595 29491.47233959211 31724.043883040486 27970.251279933243 22522.38669994741 1.434013743557476 1.1866312367664287 1.3480483694861165 1.2764603755522392 1.3169303719281926 1.275781620781915 1.309429268420339 1.4085560427356734 1.2418866460541926 1.0 14.45907209763053 -8.546604511428566 22.280002328037007 0.9999999980786711 1.313477413124139 0.6781785939809726 0.06608600518534134 780.7117144683419 733137.723034707 0.05918114356133543 0.015280505575775849 2.8405045453725677e-09 8.546604511428566 0.3134774150454678 SEGFDTYR ddPTM_A459_Selumetinib_30min_R2 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 132.08 0.047149 14383000.0 125440.0 116540.0 109620.0 151850.0 128750.0 87913.0 124160.0 105790.0 97051.0 121060.0 False True 118468.54697610615 125478.24326483817 102567.1685452318 131167.76804413914 112575.27396039614 100022.21775524328 129933.68601837248 106097.83138552264 116463.91183150836 117564.68324834578 1.0076882249225394 1.0673123917645884 0.8724318027427255 1.1157072380917146 0.9575603051010657 0.8507845637958682 1.1052101909201608 0.9024634648264194 0.9906368869764048 1.0 16.843095210166695 SEGPS(ph)LSPSGK ddPTM_A459_Selumetinib_30min_R2 1 SEGPSLSPSGK 11 0 A8MU93 A8MU93 C17orf100 Uncharacterized protein C17orf100 1 S(0.004)EGPS(0.921)LS(0.066)PS(0.008)GK 93.011 0.024201 10795000.0 62335.0 54158.0 63679.0 65652.0 66007.0 45033.0 54334.0 54231.0 43994.0 51606.0 True False 58870.67024677602 58311.744454583044 59581.96246845292 56710.08434398302 57714.61054993298 51235.88698112769 56860.6386607785 54388.803231574624 52794.02929506535 50116.0006915094 1.1746881122688992 1.1635354707077048 1.1888810289394707 1.1315764139493834 1.1516204356607995 1.0223458830346777 1.1345805306929004 1.0852582504810508 1.0534365984237377 1.0 15.61298367025197 -6.660206063505131 0.20248524668789714 0.9756399379716797 1.261717550662737 0.7105095253284694 0.03388652596892643 3.1789689820799607 0.2986820271061531 0.1057759493467461 0.2714181144972107 2.1867238237642536e-07 6.660206063505131 0.28607761269105725 SEGPSLS(ph)PSGK ddPTM_A459_Selumetinib_30min_R1 1 SEGPSLSPSGK 11 0 A8MU93 A8MU93 C17orf100 Uncharacterized protein C17orf100 1 S(0.114)EGPS(0.252)LS(0.56)PS(0.074)GK 85.973 0.034119 10432000.0 3154.1 4212.6 4010.1 4000.7 3733.1 3447.5 3769.3 3498.2 1889.5 2987.2 True False 3227.584393189763 3719.386833615394 3465.5504459025647 3302.052847440029 3395.4417641323344 3412.821280079551 3484.9786663191585 3405.4163722449703 3206.3434963801606 3370.636217792041 0.9575593996625406 1.1034672961687348 1.0281591432529904 0.9796526928684882 1.007359306889707 1.0125154598603179 1.0339231056509617 1.0103185725796635 0.9512576526221802 1.0 11.71880521482971 -8.092181082637454 6.576967099215888 0.9762494894384741 1.0193983485540883 0.1605256177587221 0.03760815704422698 0.4308134623777757 25.66873910259326 0.025448583420058866 0.009484311956224208 8.087586103460746e-09 8.092181082637454 0.04314885911561417 SEGPSLS(ph)PSGK ddPTM_A459_Selumetinib_30min_R2 1 SEGPSLSPSGK 11 0 A8MU93 A8MU93 C17orf100 Uncharacterized protein C17orf100 1 S(0.001)EGPS(0.135)LS(0.845)PS(0.018)GK 99.161 0.017531 11511000.0 70099.0 67202.0 70120.0 71138.0 75493.0 59574.0 67576.0 67731.0 59122.0 62730.0 True False 66203.17820853052 72356.17731151234 65608.55554088349 61448.88168010522 66008.89442401708 67779.77774107203 70718.41789930372 67928.08599652942 70948.05200670211 60918.82190788639 1.0867442300285197 1.1877474817375826 1.0769833277486605 1.0087010837639034 1.0835550057718983 1.1126245652543953 1.1608631894791894 1.1150590879653177 1.1646326994632403 1.0 15.894600421767231 -6.881818528144045 5.322436136856562 1.1218851299853487 1.0893094550109073 0.017976209192674508 0.058858970777228424 0.6917323252027464 29.485064719733717 0.021439541681240095 0.01890379212730096 1.3127483220804984e-07 6.881818528144045 -0.03257567497444147 SEIPS(ph)PQSQLLEDAEANLVGR ddPTM_A459_Selumetinib_30min_R1 2 SEIPSPQSQLLEDAEANLVGR 21 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 S(0.141)EIPS(0.858)PQS(0.001)QLLEDAEANLVGR;S(0.002)EIPS(0.993)PQS(0.005)QLLEDAEANLVGR 245.22 7.9637e-32 21766200.0 7715.3 8906.9 9368.5 10001.3 9260.699999999999 8025.200000000001 8798.2 8368.5 4456.9800000000005 6817.2 True False 7895.05147863954 7864.076007294525 8096.309157486899 8254.760702652524 8423.071320109377 7944.473774298595 8134.5446905285435 8146.540195281011 7563.169535060311 7692.2540251512755 1.0263638528869665 1.0223370135179422 1.0525275336740685 1.0731263782581837 1.0950069111821523 1.0327887961477402 1.0574981876483946 1.0590576141459136 0.9832188992109597 1.0 12.909190690966353 -8.260128311648756 24.980786605888873 0.9916094439680325 1.052980123797294 0.571291436845621 0.02103709828227123 84.76627715524847 1615200.8610868223 0.017544054580386263 0.00581827250959596 5.493785368187209e-09 8.260128311648756 0.061370679829261476 SEIPS(ph)PQSQLLEDAEANLVGR ddPTM_A459_Selumetinib_30min_R2 4 SEIPSPQSQLLEDAEANLVGR 21 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 S(0.002)EIPS(0.995)PQS(0.004)QLLEDAEANLVGR;S(0.084)EIPS(0.9)PQS(0.016)QLLEDAEANLVGR;S(0.011)EIPS(0.987)PQS(0.002)QLLEDAEANLVGR;S(0.401)EIPS(0.405)PQS(0.194)QLLEDAEANLVGR 209.23 9.7523e-18 44799400.0 71199.2 72668.2 81594.5 83722.3 98179.0 66305.7 63723.6 69708.5 63106.8 80442.4 True False 67242.23349698009 78241.61727490935 76344.79870337453 72319.17831097687 85844.87628860376 75438.70831178364 66686.8736659178 69911.34019413652 75729.92335131671 78119.81889754423 0.8607576725845931 1.0015591226283418 0.9772782346500614 0.925746876164997 1.0988872926240536 0.9656795084320802 0.8536485952864153 0.894924504187941 0.9694073081587412 1.0 16.253400984228357 -9.58454466836912 10.949620793006035 0.9999999761317787 0.9518056317095687 0.04527856890648152 0.06862844736297347 0.0 0.0 0.06930724563492155 0.016809476139612364 2.6028871035854514e-10 9.58454466836912 -0.048194344422210045 SEIPSPQS(ph)QLLEDAEANLVGR ddPTM_A459_Selumetinib_30min_R1 1 SEIPSPQSQLLEDAEANLVGR 21 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 S(0.001)EIPS(0.18)PQS(0.819)QLLEDAEANLVGR 159.58 1.1793e-07 14471000.0 2561.5 2794.3 3619.2 4029.1 3359.4 2873.2 3434.5 2825.0 1637.5 2798.0 True False 2621.1779661886385 2467.142056965175 3127.732518842565 3325.493320574054 3055.542863150242 2844.2982166568727 3175.432899868188 2750.071823106754 2778.717901731949 3157.150554827976 0.8302353405922572 0.7814458050447969 0.9906820927686123 1.0533211080126175 0.9678166467157058 0.900906740829105 1.005790773902833 0.8710613495771656 0.8801347460236508 1.0 11.624407344655623 -5.25940543245032 24.98075975356309 0.957429894053896 0.8058405616848513 0.5358415992820326 0.05690241963032459 139.93600072725272 1718650.8017578926 0.015759024635779127 0.03761781025052902 5.502937338326641e-06 5.25940543245032 -0.1515893323690447 SEIPSPQS(ph)QLLEDAEANLVGR ddPTM_A459_Selumetinib_30min_R2 1 SEIPSPQSQLLEDAEANLVGR 21 0 Q9ULJ8-3;Q9ULJ8;Q9ULJ8-4;Q9ULJ8-5 Q9ULJ8-3 PPP1R9A Neurabin-1 1 S(0.005)EIPS(0.409)PQS(0.586)QLLEDAEANLVGR 84.62 0.0011624 3850000.0 11560.0 14013.0 14544.0 15168.0 17471.0 10881.0 13676.0 14033.0 14072.0 14606.0 True False 10917.541478346531 15087.752041103295 13608.254874309896 13102.09223374054 15276.136787278312 12379.758982116447 14311.961098479896 14073.833706711797 16886.79320453151 14184.286829054492 0.7696926613175575 1.0636947929026777 0.9593894312990995 0.9237046875633373 1.0769760208167336 0.8727797972019484 1.009001106010059 0.992212994303214 1.190528181504432 1.0 13.792005994803832 -8.072038422718268 6.5497803267742825 1.096239258953081 0.961286578479346 0.25442102182447435 0.09502266988970516 0.3280146372145495 24.322339118436947 0.06034051927315322 0.022596277566727684 8.471524619096937e-09 8.072038422718268 -0.134952680473735 SEIS(ph)PEGEK ddPTM_A459_Selumetinib_30min_R1 1 SEISPEGEK 9 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 SEIS(1)PEGEK 111.86 0.010031 4158200.0 2082.4 2952.9 2038.3 2191.1 2274.7 2365.4 2661.7 2119.0 1262.3 2145.6 True False 2130.9158683549567 2607.1730952340326 1761.5100555804597 1808.4655170409792 2068.953786630902 2341.606223611363 2460.9258260530355 2062.7972365179503 2142.030905255718 2421.008659913831 0.8801768881036555 1.0768954024835367 0.7275934550532157 0.7469884544342549 0.8545833895135843 0.9672027458566407 1.0164878245997788 0.8520404204549066 0.8847679649902441 1.0 11.24139252450798 -6.749776392977066 24.34167676321201 0.9393765655622383 0.8561216440530508 0.15949638161257562 0.09937654213012703 358.94795432121015 749153.8001893009 0.03563705226967461 0.03533033491271527 1.779195235970787e-07 6.749776392977066 -0.08325492150918745 SELCS(ph)SPLGK ddPTM_A459_Selumetinib_30min_R2 1 SELCSSPLGK 10 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 SELCS(0.622)S(0.378)PLGK 165.63 0.00035069 86496000.0 165040.0 148060.0 166880.0 176490.0 170160.0 130090.0 139610.0 146780.0 114980.0 142490.0 True False 155867.73750746643 159415.72591206423 156143.12248520623 152451.75753776848 148782.97955029926 148008.71666055766 146102.1416319668 147207.10549926286 137979.21280962412 138375.9434665189 1.1264077671505077 1.1520479782718596 1.1283978889219732 1.1017215400208298 1.0752084200697676 1.0696130624494675 1.0558348364021621 1.063820067357884 0.9971329506635612 1.0 17.07823362797356 -6.697117320302144 0.3634499407314362 0.9946432975597931 1.1687941735571172 0.9040246059835532 0.015275764271118963 0.5089761340579392 0.13537617322332213 0.01723216360568158 0.03387194529035107 2.0085501496196606e-07 6.697117320302144 0.17415087599732415 SELCSS(ph)PLGK ddPTM_A459_Selumetinib_30min_R1 3 SELCSSPLGK 10 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 SELCS(0.341)S(0.659)PLGK;SELCS(0.238)S(0.762)PLGK;SELCS(0.337)S(0.663)PLGK 196.16 0.00013582 142128000.0 21271.8 24763.5 22104.5 23820.5 21669.2 19913.9 21218.6 20834.5 12033.599999999999 16260.2 True False 21767.391552282425 21864.17790776118 19102.830311327212 19660.6968411641 19709.224686007987 19713.58424637453 19618.06391880712 20281.901380006253 20420.14030062997 18347.355057760487 1.1864048787280292 1.1916800998797459 1.0411762486302993 1.0715820770497435 1.0742270274903445 1.0744646399610693 1.0692584221020542 1.1054400656746162 1.1129746078573186 1.0 14.163284479670581 -5.252517370330813 24.95616600102461 1.0729407676724176 1.1890425085396137 0.7186767108649095 0.0300358967808376 322.599911000782 902354.9555899919 0.00747559446844532 0.01913480422978426 5.590911653414281e-06 5.252517370330813 0.11610174086719605 SELDTEKVPLS(ph)PLPGPK ddPTM_A459_Selumetinib_30min_R1 2 SELDTEKVPLSPLPGPK 17 1 Q8NHU6-2;Q8NHU6 Q8NHU6-2 TDRD7 Tudor domain-containing protein 7 1 SELDTEKVPLS(1)PLPGPK;S(0.001)ELDT(0.007)EKVPLS(0.992)PLPGPK 72.801 0.014616 37953000.0 8135.4 8803.9 10612.5 11509.3 9870.9 8902.0 9238.7 9183.5 5527.299999999999 7741.9 True False 8324.938991267238 7773.135295177934 9171.380790289768 9499.416811318393 8978.078837848938 8812.453962369298 8541.817420879963 8939.923747787912 9379.424401980454 8735.64827749203 0.9529846814823106 0.8898177958018212 1.0498798141770922 1.0874312368773207 1.0277518682822369 1.0087922135183902 0.9778115086076113 1.0233841225982292 1.073695289008734 1.0 13.092699055007175 -5.265519521742655 24.998292813302506 1.0311217558260195 0.9214012353525042 0.6217803297532478 0.03422066727562318 212.72669825670388 1303345.712877034 0.009488797554253418 0.020985687068033342 5.42600860615157e-06 5.265519521742655 -0.10972052047351533 SELDTEKVPLS(ph)PLPGPK ddPTM_A459_Selumetinib_30min_R2 4 SELDTEKVPLSPLPGPK 17 1 Q8NHU6-2;Q8NHU6 Q8NHU6-2 TDRD7 Tudor domain-containing protein 7 1 SELDTEKVPLS(1)PLPGPK;SELDTEKVPLS(1)PLPGPK;SELDTEKVPLS(1)PLPGPK;SELDTEKVPLS(1)PLPGPK 93.215 0.0041017 29503200.0 276992.0 260667.0 279823.0 305317.0 302755.0 206881.0 255942.0 263118.0 203353.0 254690.0 True False 261597.89352683036 280659.32072349044 261819.49282824597 263732.29789879714 264720.21023595886 235376.9798712647 267843.8101394514 263883.62981847016 244029.28215755336 247336.4379359087 1.0576601478938463 1.1347269454742313 1.0585560906965523 1.0662897068451234 1.0702839114411227 0.95164700290645 1.082912863040652 1.0669015532877095 0.9866289180601351 1.0 17.91611526959123 -6.151405296908543 1.5334279061307985 1.0267269844934444 1.0901534548426508 0.3013071964616869 0.042198167742126896 0.5272695301421149 2.4776896703797084 0.015171031421169958 0.02279195256933847 7.056587045711586e-07 6.151405296908543 0.06342647034920645 SELGNQS(ph)PSTSSR ddPTM_A459_Selumetinib_30min_R1 1 SELGNQSPSTSSR 13 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;H0YD16 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 SELGNQS(1)PSTSSR 244.57 2.821299999999999e-78 0.0 2649.5 3607.5 3400.0 3203.9 3068.3 3393.7 3373.9 2732.2 1655.1 2911.6 True False 2711.2281949704457 3185.132222918748 2938.298674863153 2644.3990096515877 2790.772806752364 3359.562459233059 3119.404006657526 2659.7331805636345 2808.583816278808 3285.332221385678 0.8252523678798339 0.9695008018322518 0.894368811694741 0.8049106852689134 0.8494644129400343 1.0225944388102317 0.9494942357281093 0.8095781495856818 0.8548857853694357 1.0 11.68182355168185 SELGNQS(ph)PSTSSR ddPTM_A459_Selumetinib_30min_R2 3 SELGNQSPSTSSR 13 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;H0YD16 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 SELGNQS(0.986)PS(0.011)T(0.002)SSR;SELGNQS(0.996)PS(0.004)TSSR;SELGNQS(0.741)PS(0.233)T(0.021)S(0.004)SR 153.22 0.00041746 28824800.0 112156.0 79587.0 126278.0 147758.0 105151.0 98375.0 141306.0 110800.0 120089.0 107845.0 True False 105922.81851604095 85691.06698746077 118153.41096109094 127633.10550323316 91940.99131813287 111925.26329066303 147877.00899252697 111122.4096560725 144110.1555670116 104731.23463503891 1.0113775406654413 0.8181997212777242 1.1281582936821553 1.218672786089091 0.8778755606054229 1.0686903833483243 1.4119666354344036 1.0610245362169668 1.3759997776136028 1.0 16.676332244621875 -7.018249025282792 24.193182965437327 1.220618201751388 1.0137224151703177 0.2688530320157576 0.15706349073162265 656.7585081276183 870679.2959052727 0.05779296605722928 0.045683705193790065 9.588506670575877e-08 7.018249025282792 -0.20689578658107033 SELISS(ph)TFK ddPTM_A459_Selumetinib_30min_R2 1 SELISSTFK 9 0 H0YHG7;Q92730 H0YHG7 RND1 Rho-related GTP-binding protein Rho6 1 SELIS(0.011)S(0.495)T(0.495)FK 91.853 0.026668 3233300.0 4112.9 5749.7 59250.0 55485.0 108530.0 51184.0 9061.8 22070.0 74406.0 42377.0 True False 3884.321483243206 6190.683501800588 55437.91950652231 47927.847283036266 94895.49112948975 58234.13139790905 9483.191655616045 22134.220046114802 89289.27907734312 41153.465901331125 0.09438625394410743 0.15042921334118659 1.347102079796617 1.1646126573627429 2.305893053017931 1.4150480432809778 0.23043482360277479 0.5378458305111761 2.169666080893931 1.0 15.328726317562069 -5.257439136072418 22.90784369213846 1.2559158232549532 0.1224072116548747 0.3686580170296794 0.6011376866316265 118.91744439811279 680967.342528881 0.16467134321821647 0.4018519712635037 5.527908730461038e-06 5.257439136072418 -1.1335086116000785 SELNLRR ddPTM_A459_Selumetinib_30min_R1 1 SELNLRR 7 1 P06744-2;P06744;A0A2U3TZU2;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41;A0A2R8YF08;K7ELR7;K7ENA0;K7ERK8;K7EIL4;A0A0J9YXM3;A0A0J9YXH9;A0A0J9YYI8 P06744-2 GPI Glucose-6-phosphate isomerase 0 94.662 0.039313 0.0 1377.6 875.06 3453.7 3569.9 2187.7 1496.2 1264.6 1138.5 1011.5 754.82 False True 1409.6953996570242 772.6075683956428 2984.7065098161384 2946.483980322482 1989.8229212698059 1481.1495864409053 1169.210203864699 1108.3032816308098 1716.4416229629721 851.7084995694258 1.6551383488243736 0.9071267561451226 3.5043756300718285 3.4594981520227313 2.336272236658134 1.7390334688331608 1.3727821249356833 1.3012706603152409 2.015292349237685 1.0 9.734215936911097 -6.853719451351349 3.4716813310390315 1.4599008976676426 2.418243349170482 0.2630803782918777 0.7542229549624574 0.3811041124060442 9.01578924391141 0.3097801739006363 0.2743656558452057 1.4004917300654016e-07 6.853719451351349 0.9583424515028391 SELPDS(ph)PEPVTEINEDSVLIPPTAQPEK ddPTM_A459_Selumetinib_30min_R1 1 SELPDSPEPVTEINEDSVLIPPTAQPEK 28 0 Q86YC2 Q86YC2 PALB2 Partner and localizer of BRCA2 1 S(0.01)ELPDS(0.989)PEPVT(0.001)EINEDSVLIPPTAQPEK 107.71 1.3238e-06 0.0 886.27 639.49 1024.3 1109.5 1131.8 773.71 845.98 876.79 479.13 609.26 True False 906.9183666187793 564.6182135091647 885.2056860771553 915.7466528944211 1029.4288898355198 765.927179872473 782.1670474975948 853.5346809846969 813.0486157293607 687.464455694958 1.3192221926615468 0.8213053181613469 1.2876384789702335 1.3320640002670285 1.4974285307519934 1.114133499597731 1.1377563465545313 1.241569180652196 1.1826773137055495 1.0 9.425141312872825 -8.651122152877218 5.893702135434965 1.000000616514475 1.2146939006203905 0.1313820955583268 0.16777127211693996 5.847797780681119 268.2608440659581 0.16773299085760382 0.04348418906207959 2.232944080133947e-09 8.651122152877218 0.21469328410591548 SELS(ph)PVAR ddPTM_A459_Selumetinib_30min_R1 1 SELSPVAR 8 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 SELS(1)PVAR 148.69 0.0015317 26242000.0 4197.9 5284.9 5201.7 5472.6 5510.6 4237.4 4608.1 5089.9 2339.7 4123.8 True False 4295.702902308522 4666.141451116645 4495.3377108928435 4516.913143424975 5012.167202975447 4194.775603251369 4260.507306997406 4954.899317674709 3970.3000150731223 4653.129899213583 0.9231856826164538 1.0027963010242336 0.9660890214246098 0.9707257784031282 1.0771603869951158 0.9014954867175148 0.9156218285927215 1.0648529967994507 0.8532536381037065 1.0 12.183985747350494 -9.360964654455538 12.77750710110653 0.9999999999993863 0.9683613282975582 0.02166226870324972 0.0669981443901262 0.0 0.0 0.06143838787742644 0.014900997805076288 4.355473197512184e-10 9.360964654455538 -0.0316386717018281 SELS(ph)PVAR ddPTM_A459_Selumetinib_30min_R2 2 SELSPVAR 8 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.003)ELS(0.997)PVAR;SELS(1)PVAR 106.88 0.013539 59020000.0 146443.0 136602.0 138918.0 156278.0 176234.0 119875.0 128436.0 139320.0 111853.0 124963.0 True False 138304.28431777685 147078.93415534098 129980.16712248218 134992.66680541274 154093.90936805002 136386.69313309508 134408.52849110583 139725.39813433247 134226.72543394397 121354.99349713395 1.139667024258406 1.2119726590304218 1.0710739078532596 1.112378344848256 1.2697780695088519 1.1238655221576532 1.107564877371776 1.1513774102557417 1.1060667679662808 1.0 16.888873947947147 -9.109566846684308 0.7003847838407515 0.996953247030465 1.1537011980459397 0.4183739651028977 0.053167032976255184 2.0729659040462978 1.5768145286148951 0.06680865944359675 0.020273401457738878 7.77021710268255e-10 9.109566846684308 0.15674795101547478 SELSQDAEPAGS(ph)QETK ddPTM_A459_Selumetinib_30min_R1 2 SELSQDAEPAGSQETK 16 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2;X6RJY0 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 SELSQDAEPAGS(0.998)QET(0.002)K;SELSQDAEPAGS(0.999)QET(0.001)K 295.82 2.1345999999999998e-75 38037000.0 6557.1 8710.3 6888.799999999999 7856.9 6274.4 7034.6 7163.799999999999 6806.799999999999 4216.9 6553.1 True False 6709.867672104434 7690.494026691385 5953.338797469791 6484.8399072791135 5706.881627835294 6963.838310905757 6623.428798391529 6626.2615523975355 7155.771309809744 7394.254217599431 0.9074434655132555 1.0400635142333705 0.8051303920955211 0.8770106783513372 0.771799489156332 0.9417904910992618 0.8957534598454537 0.8961365619031655 0.967747537375431 1.0 12.852188929507946 -8.36421170331869 2.4810347673842688 0.9999292364365202 0.890246618024727 0.2304185675001822 0.06848688478390472 0.42951362606940047 5.087848356531442 0.06693990770648406 0.018573292780970255 4.323030471001862e-09 8.36421170331869 -0.10968261841179316 SELSQDAEPAGS(ph)QETK ddPTM_A459_Selumetinib_30min_R2 4 SELSQDAEPAGSQETK 16 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2;X6RJY0 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 SELSQDAEPAGS(0.999)QET(0.001)K;SELSQDAEPAGS(1)QETK;SELSQDAEPAGS(0.998)QET(0.002)K;SELSQDAEPAGS(0.969)QET(0.031)K 204.23 7.0621e-29 54473000.0 231994.0 205665.2 214516.7 229182.0 211571.0 167311.9 211726.0 205736.0 165085.8 199469.0 True False 219100.70222556425 221439.05952215227 200714.92907012295 197967.0162389979 184991.55951126196 190357.5955187915 221571.67852710994 206334.65769857148 198107.5728826502 193709.8116872975 1.1310769460622616 1.1431483908498017 1.0361629456030532 1.02197722724842 0.9549932339508477 0.982694649593086 1.143833018044483 1.0651740141674086 1.0227028314004658 1.0 17.563537504857628 -5.275493033254128 7.365183402204381 1.0302714648603746 1.1373548859062168 0.4486536657486959 0.04815723478500805 0.14416082605004868 49.18242763544327 0.013896671061846718 0.03110506556725491 5.3028209909463675e-06 5.275493033254128 0.10708342104584223 SEMEVQDAELK ddPTM_A459_Selumetinib_30min_R2 1 SEMEVQDAELK 11 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 129.84 0.034747 2965000.0 19844.0 15746.0 20396.0 23650.0 20493.0 17031.0 23013.0 21353.0 17298.0 16104.0 False True 18741.149921825996 16953.66756863002 19083.74356548573 20428.829201474415 17918.486130255522 19376.865657974926 24083.150099394403 21415.133694820546 20758.0833465027 15639.035676783064 1.1983571307819303 1.0840609305469258 1.22026344589881 1.3062716668523264 1.1457539007252484 1.2390064233142495 1.539938305476664 1.3693385025403064 1.3273250202580662 1.0 13.932863936490472 -7.01508055439922 24.558189543515862 1.3470063426137013 1.1929738613211447 0.11967899460610731 0.13646393987001154 835.8413064653406 1361138.8924848323 0.048986774688286494 0.039328189153401756 9.658717092450047e-08 7.01508055439922 -0.15403248129255664 SEMIEKPLFDFSLITTGIQEPQTDETRNS(ph)PTQK ddPTM_A459_Selumetinib_30min_R1 1 SEMIEKPLFDFSLITTGIQEPQTDETRNSPTQK 33 2 H3BSS6;Q9H2Y7;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 SEMIEKPLFDFSLIT(0.003)T(0.012)GIQEPQT(0.136)DET(0.136)RNS(0.576)PT(0.136)QK 83.435 4.9429000000000006e-06 3860900.0 715.3 942.22 853.2 988.71 867.84 1025.5 968.02 953.83 414.81 805.33 True False 731.9650982684884 831.9044443738059 737.3401262921296 816.0503588853024 789.3440252295961 1015.184401079501 895.0014720426268 928.5313299235098 703.902273476293 908.7019500784894 0.8055062479014871 0.9154865842446468 0.8114213095156687 0.8980396254402402 0.8686500839592303 1.117180832496083 0.9849230234020305 1.0218216543315524 0.7746239274775334 1.0 9.827663364662563 -6.571123900353726 24.999927518243236 0.9826792997301769 0.8615595688334167 0.3294799304219994 0.08550415339883027 138.06437592863023 71541.98028958647 0.027706414026206785 0.027706422580882652 2.6845784500386356e-07 6.571123900353726 -0.1211197308967602 SEMT(ph)PEELQK ddPTM_A459_Selumetinib_30min_R1 1 SEMTPEELQK 10 0 K7ERG4;P62316 K7ERG4 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 S(0.001)EMT(0.999)PEELQK 108.37 0.02507 4602000.0 3180.4 5063.8 2613.0 2953.9 2779.3 3137.6 3941.2 3255.2 1864.5 3173.0 True False 3254.4971320188743 4470.927941903248 2258.1689521815933 2438.0568165703753 2527.9128057252683 3106.038592712863 3643.9121109216753 3168.861521620211 3163.920322307917 3580.285457637298 0.9090049300612422 1.2487629812773933 0.6307231585025078 0.6809671590206938 0.7060645961435401 0.8675393706630868 1.0177713911466617 0.8850862756936164 0.8837061624677971 1.0 11.805858903408506 -7.0129042335964575 23.959223705836948 0.9378634839229176 0.8330312953339886 0.0912268903827742 0.16575346868112917 1100.9867772510504 2044195.1858797336 0.06727893946421462 0.05477670574249863 9.707239982800826e-08 7.0129042335964575 -0.10483218858892906 SEMT(ph)PEELQK ddPTM_A459_Selumetinib_30min_R2 2 SEMTPEELQK 10 0 K7ERG4;P62316 K7ERG4 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 S(0.232)EMT(0.768)PEELQK;S(0.02)EMT(0.98)PEELQK 169.52 0.00054448 5678000.0 50605.0 39412.0 40627.0 46119.0 46349.0 40406.0 54504.0 50693.0 41760.0 37728.0 True False 47792.5766878656 42434.77367044619 38013.10305133303 39837.512640287474 40526.22425468276 45971.55973085169 57038.54399762712 50840.50823732209 50113.16687188999 36638.69461088373 1.30442902498138 1.1581955667667456 1.0375124838656513 1.0873070960463072 1.1061044801155175 1.2547270097662153 1.5567842851225246 1.387617893521229 1.3677661664562577 1.0 15.161080482548895 -6.977838521588909 5.582355381404169 1.3667821351582252 1.1342242564993403 0.2581619989387418 0.14602129985017798 0.18974399349483384 18.040647335413148 0.05167323270492841 0.044235736906874296 1.0523530846791952e-07 6.977838521588909 -0.2325578786588849 SENPTGPTEGS(ph)DR ddPTM_A459_Selumetinib_30min_R1 1 SENPTGPTEGSDR 13 0 Q6GPG7;Q92633;Q92633-2 Q6GPG7 LPAR1 Lysophosphatidic acid receptor 1 1 SENPTGPTEGS(1)DR 125.5 0.0021222 3038300.0 1145.8 961.2 1181.5 1064.3 1268.2 1027.7 1130.8 1115.1 638.96 1015.7 True False 1172.4949106613085 848.6622571502428 1021.0587895149459 878.4399843853379 1153.4915339188951 1017.3622710769408 1045.5028455876975 1085.5239256447217 1084.2684522080278 1146.0749887558163 1.0230525246294517 0.7404945273882593 0.8909179587135145 0.7664768824062516 1.0064712564499207 0.8876925864872014 0.9122464549398287 0.947166578360785 0.9460711234830402 1.0 10.162485728727855 -6.268641031369467 24.993590713402465 0.942302478262539 0.8495884398255827 0.25351749687706626 0.07872549896736061 785.3884749139853 2725716.087300131 0.022810917819628247 0.026399836838310098 5.387148764585747e-07 6.268641031369467 -0.09271403843695625 SENPTGPTEGS(ph)DR ddPTM_A459_Selumetinib_30min_R2 1 SENPTGPTEGSDR 13 0 Q6GPG7;Q92633;Q92633-2 Q6GPG7 LPAR1 Lysophosphatidic acid receptor 1 1 SENPTGPTEGS(1)DR 164.15 0.0003628 4016200.0 13207.0 7097.0 11173.0 14805.0 11571.0 8268.3 17870.0 14314.0 10346.0 9584.7 True False 12473.007811809919 7641.31707954828 10454.141344242606 12788.533459950482 10117.347533947526 9407.183272845637 18700.99040873323 14355.65137018974 12415.489091393049 9307.964806958684 1.340035987510936 0.8209439161002834 1.1231393286346585 1.37393444487346 1.0869559290107913 1.010659523101417 2.0091384955336604 1.54229755568665 1.3338564711924097 1.0 13.18425004064362 -7.19102789061958 24.999987321527183 1.5165324094725463 1.1214534215048007 0.2681243906676978 0.27546351336304864 186.77119104597176 66313.74397771936 0.10290094514575591 0.07970672198555037 6.441278979551724e-08 7.19102789061958 -0.39507898796774565 SENSSTQSS(ph)PEMPTTK ddPTM_A459_Selumetinib_30min_R2 1 SENSSTQSSPEMPTTK 16 0 P47736-4;F2Z357;J3KPC5;P47736;P47736-3;A0A0A0MQY8;X6R8W7;P47736-2 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 SENSSTQS(0.01)S(0.99)PEMPTTK 137.17 0.00040796 2549400.0 19681.0 13308.0 17063.0 17298.0 16794.0 12179.0 12829.0 10210.0 10922.0 13842.0 True False 18587.208809285297 14328.680808035575 15965.185156789716 14941.982559285592 14684.187579735099 13856.546700045606 13425.573920181234 10239.709409643507 13106.705186177738 13442.345494164882 1.382735536544104 1.065936061102985 1.187678531527103 1.1115606696593001 1.092382842422052 1.0308131647159733 0.9987523327687918 0.7617502030496396 0.9750311202659655 1.0 13.714497268973272 -6.351910312201976 0.6143207664945259 0.9012773194088275 1.256149198096626 0.6057086774500909 0.0949340142995145 0.6236423794880518 0.5037938761738543 0.06729718573466019 0.11783542592091896 4.4472309943781973e-07 6.351910312201976 0.35487187868779846 SEPFS(ph)PSLRPEPPK ddPTM_A459_Selumetinib_30min_R2 1 SEPFSPSLRPEPPK 14 1 O60885 O60885 BRD4 Bromodomain-containing protein 4 1 S(0.008)EPFS(0.982)PS(0.009)LRPEPPK 61.265 0.047508 4637600.0 33161.0 21103.0 28849.0 30944.0 32615.0 22657.0 28377.0 28961.0 28881.0 24866.0 True False 31318.04437400078 22721.532243160113 26992.88674841624 26729.3738186226 28517.61211820056 25777.796090231826 29696.58672795877 29045.27171524834 34658.007002563594 24148.05397037305 1.2969179384982534 0.940926017104189 1.1178079517932782 1.1068955639827764 1.1809486658091979 1.0674895841237677 1.2297714244134599 1.202799685261745 1.4352298137599442 1.0 14.559619310208225 -7.279016285685123 21.33602320186338 1.2338503444165745 1.112706173534828 0.1163793327792424 0.12900551415405503 221.54708873051553 268923.6012294169 0.05085932294272478 0.034442037829880055 5.259975415465984e-08 7.279016285685123 -0.12114417088174645 SEPHS(ph)PGIPEIFR ddPTM_A459_Selumetinib_30min_R1 4 SEPHSPGIPEIFR 13 0 Q9UJJ2;Q8ND82 Q9UJJ2 ZNF280C Zinc finger protein 280C 1 SEPHS(1)PGIPEIFR;SEPHS(1)PGIPEIFR;S(0.002)EPHS(0.998)PGIPEIFR;S(0.004)EPHS(0.996)PGIPEIFR 146.1 0.00040305 48881600.0 11824.900000000001 12392.0 13995.599999999999 14405.5 15093.000000000002 11912.8 13748.300000000001 13993.1 7071.02 10192.8 True False 12100.397162749956 10941.138879115497 12095.074392327868 11889.84984972563 13727.840814885578 11792.96804795698 12711.254662180174 13621.957532005346 11999.004493132605 11501.145166279699 1.052103680790606 0.9513086497850589 1.0516408772745096 1.0337970417576832 1.1936064293088262 1.0253733760819643 1.1052164352684117 1.1844001040821286 1.0432878047929162 1.0 13.489489896672065 -6.024378870781032 24.224260728838 1.0999111823439027 1.016825481807763 0.21688910633535352 0.06437295789173363 658.322277579227 654146.9280982658 0.018144327750422348 0.02356470108128151 9.454120408598966e-07 6.024378870781032 -0.08308570053613962 SEPHS(ph)PGIPEIFR ddPTM_A459_Selumetinib_30min_R2 4 SEPHSPGIPEIFR 13 0 Q9UJJ2;Q8ND82 Q9UJJ2 ZNF280C Zinc finger protein 280C 1 SEPHS(1)PGIPEIFR;SEPHS(1)PGIPEIFR;SEPHS(1)PGIPEIFR;SEPHS(1)PGIPEIFR 134.88 0.00077861 37300300.0 156649.0 138697.0 167853.0 200460.0 166331.0 134926.0 143574.0 145552.0 144244.0 152566.0 True False 147943.07569563176 149334.61391885395 157053.52072452795 173157.00218721176 145435.0127619935 153510.8317637206 150250.47548648363 145975.53222256925 173096.8305141018 148161.02316592683 0.9985289824163067 1.007921049192626 1.0600191424747543 1.1687081965767185 0.9816010287612523 1.0361080700138152 1.0141025775599348 0.9852492180692487 1.1683020730779454 1.0 17.176806441101917 -10.460567729215121 4.139672412522434 0.9999983585246063 1.044568537709482 0.042899545733753985 0.06550227945965566 8862991.211750943 7465896.484616544 118.14258307257249 0.015703860935974617 3.462838766365866e-11 10.460567729215121 0.04457017918487571 SEPQPEEGS(ph)PAGGQK ddPTM_A459_Selumetinib_30min_R1 3 SEPQPEEGSPAGGQK 15 0 F8WE91;Q9Y6K1-3;Q9Y6K1 F8WE91 DNMT3A DNA (cytosine-5)-methyltransferase 3A 1 SEPQPEEGS(1)PAGGQK;SEPQPEEGS(1)PAGGQK;SEPQPEEGS(1)PAGGQK 190.46 2.7468e-05 27621500.0 9262.5 9952.400000000001 10596.0 11615.699999999999 8986.3 9305.7 10166.400000000001 9463.7 5171.2 8798.2 True False 9478.29822831242 8787.168381254764 9157.12139966175 9587.236048693761 8173.4907516601215 9212.09310689957 9399.540262984408 9212.69193357004 8775.148710495418 9927.534671725336 0.9547484387345039 0.8851309687471094 0.9223963151437986 0.9657217391543561 0.8233152561974005 0.927933612071543 0.946815153389017 0.927993931847829 0.8839202279985952 1.0 13.27721977900552 -10.610807287508013 4.862566024850477 1.000002217409219 0.9150951148976327 0.28968360340763855 0.039773586866396475 55302858.65626304 0.01264529249442293 1930.8734417882747 0.009418132799288634 2.4501502227521563e-11 10.610807287508013 -0.08490710251158617 SEPQPEEGS(ph)PAGGQK ddPTM_A459_Selumetinib_30min_R2 4 SEPQPEEGSPAGGQK 15 0 F8WE91;Q9Y6K1-3;Q9Y6K1 F8WE91 DNMT3A DNA (cytosine-5)-methyltransferase 3A 1 SEPQPEEGS(1)PAGGQK;SEPQPEEGS(1)PAGGQK;SEPQPEEGS(1)PAGGQK;SEPQPEEGS(1)PAGGQK 260.44 2.1504999999999998e-36 48580600.0 148478.0 126947.0 158558.0 158161.0 155834.0 115920.0 127076.0 127183.0 106505.0 132757.0 True False 140226.18716452716 136683.4267010588 148356.55090489713 136619.1989570569 136256.739746364 131886.92778301061 132985.28579631707 127553.0814737208 127808.97599833891 128923.96046588977 1.0876658354102275 1.0601863781342802 1.1507290837853896 1.0596881949899695 1.0568767764655687 1.0229822858870734 1.0315017108980438 0.9893667632671611 0.9913516117289473 1.0 16.97616088734449 -6.7390405046122295 1.0054950038947694 0.9959549854319103 1.0953520633009537 0.7289708798411825 0.024557761041400072 0.27875368676918155 0.6057009793980703 0.014024331248223986 0.0130630427273622 1.8237256040422898e-07 6.7390405046122295 0.0993970778690434 SEPRPPIS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 SEPRPPISSPR 11 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 SEPRPPIS(0.5)S(0.5)PR 81.789 0.022668 37678000.0 4873.3 3732.5 5291.4 5251.5 5199.2 5048.3 4924.6 5072.4 2922.8 4023.0 True False 4986.838408208898 3295.4971648078254 4572.856943579669 4334.424107863952 4728.933277993313 4997.518685489658 4553.133457181793 4937.863474522722 4959.778127134129 4539.3912373384355 1.0985698626701346 0.7259777781877338 1.007372289474845 0.9548470006752136 1.0417549470280978 1.100922662136484 1.0030273266006071 1.0877809856763792 1.0926086490051423 1.0 12.1482831201165 -6.066283888158359 1.7061885495196571 1.0604893740546824 0.9179035519006165 0.23606866476525357 0.09325694765143253 0.4509522806214021 2.6251801798085004 0.029966876709129415 0.04704252706355554 8.58452187916958e-07 6.066283888158359 -0.1425858221540659 SEPRPPIS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 SEPRPPISSPR 11 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 SEPRPPIS(0.5)S(0.5)PR;SEPRPPIS(0.748)S(0.251)PR 80.96 0.023534 14141700.0 195509.0 138875.0 153782.0 179331.0 173416.0 126340.0 164288.0 149670.0 157102.0 159506.0 True False 184643.39246453712 149526.26594649392 143887.83354518184 154905.8084367698 151629.93172129 143742.1881996684 171927.71753049624 150105.51492079775 188526.78979663938 154900.6473336415 1.1920117549078573 0.9653043322951926 0.9289040170068554 1.0000333187963841 0.9788850746032927 0.9279637669303031 1.1099225244693782 0.9690438194069293 1.2170820008942267 1.0 17.240983647635197 -8.231034978495371 24.956131917829726 1.1085411626447774 1.0042406259242396 0.15580497946306937 0.09214021451827237 989.306940184592 812032.1172274192 0.05963847456597622 0.022535498911748667 5.874420374775747e-09 8.231034978495371 -0.10430053672053785 SEPSDHS(ph)RHSPQQPSNGSLR ddPTM_A459_Selumetinib_30min_R1 1 SEPSDHSRHSPQQPSNGSLR 20 1 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 S(0.014)EPS(0.174)DHS(0.617)RHS(0.195)PQQPSNGSLR 52.731 0.024447 2246100.0 563.34 366.79 731.15 819.54 1089.7 524.0 804.16 363.88 191.07 186.54 True False 576.4647259311762 323.84605628395514 631.8638459194686 676.422723671108 991.1368274021613 518.7290357539331 743.5015637670692 354.22872035118047 324.2318347993424 210.4842260534705 2.738754997178428 1.5385763691464778 3.001953437398927 3.2136504305043383 4.708841351134679 2.4644556291935977 3.5323386350965476 1.6829228821222628 1.540409183522265 1.0 7.717568309778365 -7.8712094693158265 5.358791426720134 1.3826196737462726 3.017226681613728 0.4847662177073496 0.7700599466540218 0.2013188373402029 8.596226102761435 0.46695690068502366 0.21897009823050187 1.3452113739672411e-08 7.8712094693158265 1.6346070078674555 SEPSLEPES(ph)FRSPTFGK ddPTM_A459_Selumetinib_30min_R2 1 SEPSLEPESFRSPTFGK 17 1 Q9C0B5-2;Q9C0B5;H0YEF4 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5;Palmitoyltransferase 1 SEPSLEPES(0.969)FRS(0.027)PT(0.003)FGK 85.49600000000002 0.0064309 7189200.0 20514.0 7218.0 17625.0 16133.0 11732.0 8886.9 25963.0 18437.0 9480.8 14590.0 True False 19373.914004048504 7771.597390471954 16491.026688649054 13935.657569022702 10258.121274589264 10110.989807753947 27170.330944708512 18490.64861759034 11377.224915685221 14168.74879062748 1.367369433274461 0.5485027298679194 1.1639014095272648 0.9835489198764702 0.7239962699723305 0.7136120455775382 1.9176238739359597 1.3050304505237444 0.8029802125654998 1.0 13.790424742374386 SEPSLEPESFRS(ph)PTFGK ddPTM_A459_Selumetinib_30min_R1 2 SEPSLEPESFRSPTFGK 17 1 Q9C0B5-2;Q9C0B5;H0YEF4 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5;Palmitoyltransferase 1 SEPSLEPES(0.272)FRS(0.578)PT(0.15)FGK;SEPSLEPES(0.004)FRS(0.71)PT(0.286)FGK 108.17 0.0013027000000000002 14601300.0 4727.2 3683.9 5784.7 3595.2000000000003 5278.1 4096.8 4441.4 6373.6 2905.2 4184.1 True False 4837.334562470006 3252.5872754013544 4999.169513082613 2967.3658102623003 4800.696786924238 4055.5899115967813 4106.381622208347 6204.5514236294475 4929.912212587268 4721.169991585321 1.024605038812779 0.6889367002667846 1.0588836076635195 0.6285233989776099 1.0168447218551036 0.8590222167016178 0.8697805055796064 1.3141978439005586 1.0442140870534198 1.0 12.204928714564783 -7.732858583340164 24.95942431960079 1.1344044406386495 0.8727690872548082 0.34503781188179394 0.15186287261798018 189.2335716518359 165256.5710149068 0.06555385104824459 0.03783865965655151 1.849870883075164e-08 7.732858583340164 -0.26163535338384136 SEPSLEPESFRS(ph)PTFGK ddPTM_A459_Selumetinib_30min_R2 1 SEPSLEPESFRSPTFGK 17 1 Q9C0B5-2;Q9C0B5;H0YEF4 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5;Palmitoyltransferase 1 SEPSLEPES(0.032)FRS(0.571)PT(0.397)FGK 112.55 0.0010507 6695600.0 36283.0 10060.0 23181.0 27839.0 16226.0 13091.0 34950.0 24497.0 17808.0 18170.0 True False 34266.53611235702 10831.569652001654 21689.559697564462 24047.28017504637 14187.54481771952 14894.166421733884 36575.244252111166 24568.282214303345 21370.097597093332 17645.384888670415 1.941954586343909 0.6138471742237988 1.229191646110859 1.3628084809012255 0.8040371409993401 0.84408283047977 2.0727937918540422 1.3923347305435043 1.211087076418177 1.0 14.10700327869061 SEPVINNDNPLESNDEKEGQEAT(ph)CSRPQIVPEPMDFR ddPTM_A459_Selumetinib_30min_R1 1 SEPVINNDNPLESNDEKEGQEATCSRPQIVPEPMDFR 37 2 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6;H7C4B4 P23497-5 SP100 Nuclear autoantigen Sp-100 1 SEPVINNDNPLES(0.228)NDEKEGQEAT(0.582)CS(0.189)RPQIVPEPMDFR 47.534 0.015535 17069000.0 774.28 1128.6 1421.6 973.02 808.07 938.22 1049.1 1064.3 743.62 778.27 True False 792.3192175133862 996.462987328094 1228.5545282898408 803.1003228475258 734.9802111763457 928.782358635601 969.9655423647445 1036.0713066663775 1261.8688281440673 878.1685354917684 0.9022404988237172 1.134705864598168 1.3989962958555089 0.9145173054939792 0.8369466468811273 1.0576356600108534 1.1045323342421627 1.1798091878641321 1.4369324077836942 1.0 9.778354033846101 -7.733248627966203 2.8677082464783727 1.2398641025510777 1.0489925312090842 0.14328111240522912 0.17681158918233333 0.5051879542424185 8.397623652447779 0.11068837138837075 0.05189735381649768 1.848210239627323e-08 7.733248627966203 -0.1908715713419935 SEPVKEES(ph)SELEQPFAQDTSSVGPDR ddPTM_A459_Selumetinib_30min_R1 3 SEPVKEESSELEQPFAQDTSSVGPDR 26 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEES(0.738)S(0.261)ELEQPFAQDTSSVGPDR;S(0.001)EPVKEES(0.5)S(0.5)ELEQPFAQDTSSVGPDR;SEPVKEES(0.5)S(0.5)ELEQPFAQDTSSVGPDR 114.64 4.293399999999999e-09 77371000.0 5345.9 6596.6 7388.6 6650.9 5073.0 5913.2 6698.9 5613.2 3715.25 5600.699999999999 True False 5470.449068689373 5824.267005323858 6385.268702674675 5489.445167855342 4614.1480457108955 5853.718576756027 6193.5965796846685 5464.319701756751 6304.507898876103 6319.604400437823 0.8656315683795619 0.9216189236339465 1.0103905716364625 0.8686374684268264 0.7301324186354492 0.9262792741188801 0.9800608055870674 0.8646616711290002 0.9976111635151287 1.0 12.625618534933192 -8.274717650905849 23.331647995890716 0.9988056693113951 0.8979785868968972 0.2455554426371651 0.0720598215153349 573.5591095370758 1007793.9890508476 0.07211002987321692 0.019156030387815846 5.312297018487613e-09 8.274717650905849 -0.10082708241449789 SEPVKEES(ph)SELEQPFAQDTSSVGPDR ddPTM_A459_Selumetinib_30min_R2 3 SEPVKEESSELEQPFAQDTSSVGPDR 26 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 S(0.003)EPVKEES(0.763)S(0.233)ELEQPFAQDTSSVGPDR;S(0.003)EPVKEES(0.474)S(0.474)ELEQPFAQDT(0.012)S(0.025)S(0.012)VGPDR;S(0.008)EPVKEES(0.749)S(0.241)ELEQPFAQDTSSVGPDR 74.123 0.00011484 73900200.0 89161.3 85776.9 80725.7 87082.90000000001 79468.79999999999 57322.4 79405.40000000001 77362.5 63076.100000000006 70852.4 True False 84206.07188696355 92355.71241379545 75531.8963494967 75222.05879361849 69485.21888391407 65218.04027906185 83097.90843881507 77587.61206694858 75693.08249348699 68806.7071153568 1.223806158108819 1.3422486889099043 1.0977403150955167 1.0932373012344005 1.0098611283260472 0.9478442293383053 1.2077007013211456 1.1276169914201868 1.1000829085830972 1.0 16.070261581837812 -5.33402377665261 5.925900210519808 1.07516760981087 1.2822627743764332 0.5637270457704647 0.07397932354820178 0.15470817096756972 9.709273234485094 0.020428143899950797 0.043661947856083135 4.634215477473735e-06 5.33402377665261 0.2070951645655632 SEPVKEES(ph)SELEQPFAQDTSSVGPDRK ddPTM_A459_Selumetinib_30min_R2 5 SEPVKEESSELEQPFAQDTSSVGPDRK 27 2 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEES(0.549)S(0.451)ELEQPFAQDTSSVGPDRK;SEPVKEES(0.5)S(0.5)ELEQPFAQDTSSVGPDRK;S(0.011)EPVKEES(0.912)S(0.077)ELEQPFAQDTSSVGPDRK;S(0.039)EPVKEES(0.569)S(0.39)ELEQPFAQDT(0.001)S(0.001)S(0.001)VGPDRK;S(0.004)EPVKEES(0.498)S(0.498)ELEQPFAQDTSSVGPDRK 105.51 2.6484e-09 49250100.0 148160.2 139773.9 130647.0 134664.9 111290.3 86793.9 103484.8 104862.3 71182.6 113092.4 True False 139926.04921627327 150494.1086860751 122241.31425769815 116323.30831009004 97309.01756609455 98748.97188842163 108297.04825124094 105167.4319321117 85421.10900802184 109827.1285626565 1.2740572484005654 1.3702817387255832 1.1130338729374987 1.059149135850597 0.8860198644871213 0.8991309631853411 0.9860682844808909 0.9575724441535732 0.7777778598599071 1.0 16.744874935051463 -5.63843329441846 1.5395350692961218 0.9190612148471952 1.332894407977453 0.8310450053048456 0.07031034058551855 0.15266989798490954 0.7126810084556026 0.02176636683061643 0.05772868474272552 2.2991468202394958e-06 5.63843329441846 0.4138331931302578 SEPVKEESS(ph)ELEQPFAQDTSSVGPDR ddPTM_A459_Selumetinib_30min_R1 1 SEPVKEESSELEQPFAQDTSSVGPDR 26 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEES(0.179)S(0.821)ELEQPFAQDTSSVGPDR 110.13 1.1755e-08 44205000.0 4532.7 4938.7 4811.7 5506.9 3941.8 4325.0 3981.3 4504.4 2876.9 4502.2 True False 4638.303090901129 4360.4747080606585 4158.297568776185 4545.223292315717 3585.264885981312 4281.494426785802 3680.9873356369794 4384.928679646748 4881.889179537492 5080.101225141713 0.9130335962492045 0.858344059460945 0.8185462030159026 0.8947111663486439 0.7057467414699593 0.842797069789956 0.7245893679085686 0.8631577374768604 0.9609826582542769 1.0 12.310641528816024 -8.251208283768934 3.1297494228929623 0.9927093646966513 0.8214874138861485 0.49965930896420163 0.06244696941108028 0.20641631360921145 3.8723684046045506 0.056110476154984 0.01634862107129819 5.6077896692801594e-09 8.251208283768934 -0.17122195081050273 SEPVKEESS(ph)ELEQPFAQDTSSVGPDR ddPTM_A459_Selumetinib_30min_R2 2 SEPVKEESSELEQPFAQDTSSVGPDR 26 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEES(0.178)S(0.822)ELEQPFAQDTSSVGPDR;SEPVKEES(0.191)S(0.809)ELEQPFAQDTSSVGPDR 133.4 2.8267e-09 66264000.0 148707.0 123492.0 130131.0 116031.0 120070.0 108128.0 119400.0 116917.0 84729.0 115118.0 True False 140442.4602612868 132963.43931063527 121758.51313592026 100227.37763536036 104985.73316058076 123021.6505117441 124952.33658661165 117257.20911334855 101677.16752606229 111794.24422751598 1.256258416806038 1.1893585419302732 1.0891304286482377 0.8965343281124963 0.9390978389452769 1.1004291979592336 1.1176991932815183 1.0488662446227082 0.9095027049794789 1.0 16.770486386784476 -5.308567873784117 2.7752569369550173 1.0096757164944246 1.236646125904676 0.5958551545930562 0.07206227945135904 0.20876873646935076 3.125799013920832 0.021624868992514992 0.06182737371698822 4.9139657620349985e-06 5.308567873784117 0.22697040941025137 SEPVKEESS(ph)ELEQPFAQDTSSVGPDRK ddPTM_A459_Selumetinib_30min_R1 2 SEPVKEESSELEQPFAQDTSSVGPDRK 27 2 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEES(0.148)S(0.852)ELEQPFAQDTSSVGPDRK;S(0.001)EPVKEES(0.175)S(0.793)ELEQPFAQDT(0.022)S(0.008)S(0.002)VGPDRK 139.25 3.2294e-12 26581000.0 1713.72 2241.8 2541.8 1999.4700000000003 1667.0 1932.83 1838.17 1698.8000000000002 1310.1 1734.88 True False 1753.6463416813563 1979.3290138154546 2196.637521107988 1650.3000992003674 1516.220144332755 1913.3874850692257 1699.515356980843 1653.7423055199129 2223.1440140818463 1957.5687471622423 0.8958287386961511 1.0111159654978947 1.1221253528348918 0.8430355774696026 0.7745424759823729 0.9774305438023245 0.8681765886610715 0.8447939863758213 1.135665869872816 1.0 10.934847258563316 -5.778890979279396 24.998394873129907 0.9081616259976965 1.0098326867893463 0.11668273257762418 0.10876977040940929 444.14566418871357 636211.3142391726 0.030690508516331507 0.04563828513747377 1.663830268407976e-06 5.778890979279396 0.10167106079164989 SEPVKEESSELEQPFAQDT(ph)SSVGPDR ddPTM_A459_Selumetinib_30min_R1 1 SEPVKEESSELEQPFAQDTSSVGPDR 26 1 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEES(0.078)S(0.078)ELEQPFAQDT(0.647)S(0.185)S(0.012)VGPDR 81.48 0.00018042 57052000.0 1459.4 1696.1 1851.9 1881.4 1434.4 1303.0 1622.8 1343.1 812.66 1450.1 True False 1493.4011805019325 1497.5198235045016 1600.42215175855 1552.8488082519732 1304.6587732638882 1289.8930030293413 1500.390889476224 1307.4766249963468 1379.0246656619759 1636.234460170137 0.9127061046903067 0.9152232518980123 0.9781129726311575 0.9490380786201671 0.7973544165108396 0.7883301778739076 0.9169779307301791 0.7990765729627735 0.8428038274652788 1.0 10.676163775172135 -6.244902066481571 24.44393164905826 0.8469006727507711 0.9398983996870095 0.27838287868562506 0.06279463631828062 706.1559879808884 1043774.2805850606 0.01784539019844432 0.022967149083590724 5.689812217917205e-07 6.244902066481571 0.09299772693623842 SEPVKEESSELEQPFAQDT(ph)SSVGPDRK ddPTM_A459_Selumetinib_30min_R1 3 SEPVKEESSELEQPFAQDTSSVGPDRK 27 2 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEESSELEQPFAQDT(0.349)S(0.349)S(0.302)VGPDRK;SEPVKEES(0.004)S(0.048)ELEQPFAQDT(0.47)S(0.239)S(0.239)VGPDRK;SEPVKEES(0.002)S(0.008)ELEQPFAQDT(0.794)S(0.086)S(0.11)VGPDRK 78.122 0.00039341 43200000.0 3169.08 3904.23 3852.33 4280.3 3145.0 3397.3599999999997 4013.14 3770.35 2091.6400000000003 3451.21 True False 3242.91339804376 3447.120936572715 3329.2047453339924 3532.825956182054 2860.5353052948485 3363.1856429560708 3710.425618802451 3670.3480701771828 3549.360312658696 3894.2064211321845 0.8327533385097058 0.8851921454052027 0.8549122427788699 0.9072004855754245 0.7345618069375965 0.8636382562325171 0.9528066100111093 0.9425150270051894 0.9114463715631105 1.0 11.927113644028653 -7.209908585887045 5.11087127199324 0.9470829058654205 0.8453145001698062 0.5460332612843812 0.04712701042219585 0.1746248327544299 10.35032717578215 0.018737311133133185 0.014152557467380818 6.167248018475831e-08 7.209908585887045 -0.1017684056956143 SEPVKEESSELEQPFAQDTSS(ph)VGPDRK ddPTM_A459_Selumetinib_30min_R1 1 SEPVKEESSELEQPFAQDTSSVGPDRK 27 2 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 SEPVKEESSELEQPFAQDT(0.195)S(0.342)S(0.463)VGPDRK 67.744 0.00038382 29656000.0 3155.5 4761.7 5423.7 4856.3 3743.6 4350.6 4308.3 4150.7 2819.2 4021.5 True False 3229.0170104658387 4204.197950345726 4687.191330251551 4008.2383690411707 3404.9920409862634 4306.836914028742 3983.3214623677723 4040.6099526262633 4783.976493778751 4537.698697727196 0.7115979322477187 0.9265044310790156 1.0329445920680524 0.8833196375618291 0.750378609908967 0.9491235978682132 0.8778285487229252 0.8904535584634761 1.054273721649899 1.0 12.147745102194586 -8.251658954830946 21.773042299464247 1.027136819714309 0.8828850341906588 0.314751038854589 0.0878983243263905 133.39188961608642 296965.8043965985 0.06267818304344605 0.022844876271950088 5.601973436745481e-09 8.251658954830946 -0.14425178552365014 SEPVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 SEPVSPSR 8 0 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 SEPVS(0.999)PS(0.001)R;S(0.113)EPVS(0.465)PS(0.422)R 105.17 0.01427 101437000.0 10070.3 13290.3 9551.599999999999 10197.4 10548.6 9936.7 10590.0 10456.599999999999 5921.9 8666.3 True False 10304.91839660723 11734.265497507155 8254.545183183203 8416.615518905428 9594.480992506598 9836.74581980173 9791.187773942083 10179.257000176309 10049.031781536749 9778.704021910537 1.0538122816190814 1.1999816612932463 0.8441348837931647 0.8607086890089769 0.9811607929853321 1.0059355306962092 1.0012766264326618 1.0409617652163599 1.0276445384808157 1.0 13.255427561183803 -9.948517078679238 15.41520340476403 0.9999999967867343 0.9994414785316285 0.0 0.09457195415697442 0.0 0.0 0.09845608145611293 0.023879107254586467 1.1258561936032214e-10 9.948517078679238 -0.0005585182551058887 SEQSSMSIEFGQES(ph)PEQSLAMDFSR ddPTM_A459_Selumetinib_30min_R1 8 SEQSSMSIEFGQESPEQSLAMDFSR 25 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SEQSSMSIEFGQES(0.995)PEQS(0.005)LAMDFSR;SEQSSMSIEFGQES(0.999)PEQS(0.001)LAMDFSR;SEQSSMSIEFGQES(1)PEQSLAMDFSR;SEQSSMSIEFGQES(0.99)PEQS(0.01)LAMDFSR;SEQSSMSIEFGQES(0.735)PEQS(0.264)LAMDFS(0.001)R;SEQSSMSIEFGQES(0.997)PEQS(0.003)LAMDFSR;SEQSSMSIEFGQES(1)PEQSLAMDFSR;SEQSSMSIEFGQES(0.497)PEQS(0.497)LAMDFS(0.007)R 169.36 6.800500000000002e-16 104778900.0 10525.720000000001 12609.22 12220.749999999998 10829.740000000002 11933.52 9399.19 12198.01 12449.099999999999 6890.5 10951.12 True False 10770.948796514176 11132.926660532656 10561.239273774663 8938.529208397324 10854.135223034074 9304.642682381698 11277.904285025803 12118.909427624165 11692.675237791744 12356.802924942003 0.8716614533661611 0.900955265545348 0.8546902736837354 0.7233690836288285 0.8783934881024267 0.7529975786536524 0.9126878816090478 0.9807479735039187 0.9462540843951044 1.0 13.593017902649047 -7.503354429147518 5.410783981357961 0.969063017387453 0.8316227385701418 0.6000310557417884 0.05357985527243765 0.13019502598869134 11.945782460032257 0.0248388685449369 0.015477690303851634 3.137946760000164e-08 7.503354429147518 -0.13744027881731125 SEREEVSSWR ddPTM_A459_Selumetinib_30min_R1 1 SEREEVSSWR 10 1 Q14152-2;Q14152 Q14152-2 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 117.71 0.016738999999999997 9791100.0 1689.7 1981.4 2597.2 2911.5 2448.1 1917.7 2039.0 2035.4 1159.0 1596.0 False True 1729.0667224161389 1749.416766872131 2244.514505398406 2403.061180623801 2226.6697872471595 1898.4096791322854 1885.1965883916816 1981.4145800890215 1966.738349989208 1800.8621463564848 0.9601327485917771 0.9714329164014922 1.2463555358412755 1.3343948538680148 1.2364465496441086 1.0541671293236738 1.0468300376049453 1.1002588866104113 1.092109328839148 1.0 10.814472033713214 -6.797567920556483 24.965242762603015 1.0641989906928382 1.1554706879768586 0.1399917518066518 0.11200935911541232 417.2358921639958 288311.9198301819 0.04517418014396529 0.03984126605238963 1.5937936032788727e-07 6.797567920556483 0.0912716972840204 SERPPTILMTEEPS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 SERPPTILMTEEPSSPK 17 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 SERPPTILMTEEPS(0.501)S(0.499)PK 91.657 0.004571899999999999 9438600.0 2474.0 2835.3 2462.4 2340.0 1986.2 1912.6 2489.8 2669.6 1692.0 2207.0 True False 2531.6393864340002 2503.341757904792 2128.0196049950077 1931.3629272401488 1806.5485606920915 1893.3609805018548 2301.9923814505205 2598.793535917093 2871.200421209439 2490.289948000479 1.0166042666906003 1.0052410804271175 0.8545268420264284 0.775557452171741 0.7254370368167844 0.7602974031285334 0.9243872920496075 1.0435706645339569 1.152958282434061 1.0 11.282098011770483 -7.701652171608858 3.1793333008879276 1.0805146904914171 0.8528967383943357 0.4820281162110672 0.09675218987815828 0.2339403631517632 4.754663200351754 0.062228188615617165 0.030849460103866345 1.9876862268096412e-08 7.701652171608858 -0.22761795209708147 SERPPTILMTEEPSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SERPPTILMTEEPSSPK 17 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 SERPPTILMTEEPS(0.025)S(0.975)PK;SERPPTILMTEEPS(0.122)S(0.878)PK 129.51 0.00051302 21529100.0 4098.9 5520.4 4674.4 4687.9 3873.7 4214.7 4746.7 5120.9 3146.36 4921.700000000001 True False 4194.396394928989 4874.069001635664 4039.642154641271 3869.2462677816648 3523.32451895728 4172.303944641416 4388.652597409908 4985.077096972523 5339.143118957759 5553.448136417744 0.7552778547482012 0.8776653498703035 0.7274115208082317 0.6967286220624589 0.6344390786424096 0.7512997046430984 0.7902572401154738 0.8976543895822084 0.961410458476304 1.0 12.439168103804612 -7.87558930656204 1.6818094000024397 0.9878621992870963 0.7393846942103678 0.7442471805134852 0.057346019268551617 0.2189628686740097 1.1474022933677674 0.05324784231892804 0.019227223212322654 1.3317131660414287e-08 7.87558930656204 -0.2484775050767285 SERPPTILMTEEPSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SERPPTILMTEEPSSPK 17 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 SERPPTILMTEEPS(0.175)S(0.825)PK;SERPPTILMTEEPS(0.271)S(0.729)PK 116.39 0.00089311 28982000.0 139534.0 107616.0 100769.0 92224.0 103960.0 78898.0 108774.0 115467.0 67871.0 89754.0 True False 131779.25887885864 115869.80116002061 94285.63224899159 79662.93210472613 90899.61538580798 89765.48333526537 113832.20653159209 115802.98985340922 81447.09647418706 87162.56881110204 1.5118790172929564 1.329352757043366 1.0817215868583059 0.9139580578145986 1.0428744428448964 1.0298627559933937 1.3059758114551243 1.3285862433033204 0.9344274450045006 1.0 16.411421095007704 -5.046988415712649 2.793448070581084 1.0905622465178335 1.5051550035518952 0.5347099278239551 0.13201440479072574 0.2511616017579992 3.600008576066872 0.03796625770393542 0.1789149012602836 8.974527326627984e-06 5.046988415712649 0.41459275703406173 SERSS(ph)LT(ph)T(ph)PRKMT(ph)WLMQTTK ddPTM_A459_Selumetinib_30min_R1 2 SERSSLTTPRKMTWLMQTTK 20 3 A0A087X202 A0A087X202 EIF2D 4 S(0.112)ERS(0.424)S(0.476)LT(0.972)T(0.864)PRKMT(0.636)WLMQT(0.246)T(0.27)K;S(0.302)ERS(0.336)S(0.375)LT(0.979)T(0.919)PRKMT(0.657)WLMQT(0.224)T(0.207)K 53.99800000000001 0.026138 10109900.0 338.9 89.305 346.92999999999995 472.91 463.01 173.41 351.46000000000004 378.11 0.0 322.66 True False 346.7957106153931 78.84912908323187 299.8188115500804 390.325146120145 421.13082725105505 171.66565284368238 324.9490892379308 368.0812945256261 0.0 364.0765539745512 0.9525351380897601 0.21657293836269226 0.8235048598351588 1.072096354074557 1.156709550927281 0.47150977169400954 0.8925295674509286 1.0109997210953465 0.0 1.0 8.508098025987593 -11.235502890882744 14.345352401811736 1.000019003205218 0.7480381314126328 0.04469710744835542 0.3644243567021944 0.0002181022696657668 4.3692919025576826e-06 0.34745984554586123 0.08426506882789878 5.814295620076445e-12 11.235502890882744 -0.2519808717925853 SES(ph)DLEDVGPTAEWNGDGSGSLRR ddPTM_A459_Selumetinib_30min_R1 1 SESDLEDVGPTAEWNGDGSGSLRR 24 1 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 S(0.214)ES(0.786)DLEDVGPTAEWNGDGSGSLRR 105.52 3.1985e-07 5432600.0 387.42 384.9 391.64 409.76 365.73 327.72 317.09 238.43 214.17 398.84 True False 396.44613221190787 339.8357290648445 338.45743912453094 338.2031081478304 332.64978607487575 324.4234343459524 293.1716460093762 232.1060618702099 363.43084764209516 450.0349990305894 0.8809228905882517 0.7551317781880903 0.7520691498518887 0.7515040138574697 0.7391642578720087 0.7208848979407954 0.6514418803890606 0.5157511357342974 0.8075612972878857 1.0 8.81389339336017 -1.522903014440935 0.7592215953007557 0.7136488723255854 31.162308011937764 0.0800116416700769 0.11668069697954572 781.938386358267 3.2495596278170313 0.04168126799230934 40766.603014185086 0.029998323592618437 1.522903014440935 30.44865913961218 SES(ph)ELIDELSEDFDR ddPTM_A459_Selumetinib_30min_R1 2 SESELIDELSEDFDR 15 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 S(0.017)ES(0.983)ELIDELSEDFDR;S(0.114)ES(0.886)ELIDELSEDFDR 331.73 3.8447999999999985e-127 17199800.0 1008.56 1055.46 687.5 817.13 1029.8 835.46 1209.76 918.78 585.1 748.02 True False 1032.0574856838618 931.8862525299583 594.1412761671812 674.4335849298051 936.6547718259566 827.0560309369871 1118.5068292166359 894.4109697819546 992.8719659867862 844.0356533318161 1.2227652725448657 1.1040839908259248 0.7039291217400815 0.7990581704309412 1.1097336565446354 0.9798828138031821 1.3251890779747866 1.0596838726554771 1.1763388928743015 1.0 9.721160131596523 -6.801173024370014 2.156528302499064 1.1398569515108994 0.9581231982392002 0.14712621035168794 0.1647481748898012 0.5630520804925411 5.378830327685894 0.06960230806417822 0.062440041107014434 1.5806181902531936e-07 6.801173024370014 -0.18173375327169916 SES(ph)ELIDELSEDFDRSECK ddPTM_A459_Selumetinib_30min_R1 3 SESELIDELSEDFDRSECK 19 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 S(0.336)ES(0.664)ELIDELSEDFDRSECK;S(0.448)ES(0.55)ELIDELS(0.002)EDFDRSECK;S(0.421)ES(0.579)ELIDELSEDFDRSECK 175.59 5.1893e-13 56428000.0 2026.0900000000001 2250.53 3257.16 3904.85 2847.59 2650.55 2663.13 2390.13 1530.72 1653.02 True False 2073.293954915142 1987.036901356988 2814.8555622991967 3222.9412506126914 2590.0259872828487 2623.887873506846 2462.2479600017377 2326.73598816359 2597.5200406345816 1865.2012187783205 1.1115658375309871 1.0653203961867814 1.5091431068991505 1.727932202791327 1.3886040611635875 1.4067586097898082 1.320097764901995 1.2474450288465755 1.3926218868417422 1.0 10.865115562152974 -9.887032764423937 0.6860460443344173 0.9728173179796967 1.365603632456186 0.2524809372069694 0.1804428146249637 16.452167329364304 6.411798457004343 1.397966978602711 0.07405488670512567 1.2970814117429183e-10 9.887032764423937 0.39278631447648926 SES(ph)ENWR ddPTM_A459_Selumetinib_30min_R2 2 SESENWR 7 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1;C9IYH5;C9JH78 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 S(0.002)ES(0.998)ENWR;SES(1)ENWR 117.31 0.011687 47029000.0 191783.0 137286.0 187169.0 209899.0 265650.0 77852.0 138129.0 179824.0 121822.0 140786.0 True False 181124.4686281776 147815.39475593407 175126.75031419922 181310.39410402894 232276.67205886796 88575.406329908 144552.27219742083 180347.2580685341 146189.80399107747 136721.14237404242 1.3247729318458759 1.0811451117892208 1.2809046740926617 1.3261328201018026 1.6989082158442197 0.647854492669341 1.0572781187122762 1.3190882912252089 1.0692552845347842 1.0 17.060876831057946 -6.759243638294071 24.999828806888658 1.0410497352528107 1.3235429191375894 0.37136525567372847 0.20883832244287803 78.98035370234112 899241.3610275905 0.07434650768223224 0.07092114533667844 1.740829997424757e-07 6.759243638294071 0.2824931838847786 SES(ph)ETSTMAAK ddPTM_A459_Selumetinib_30min_R2 1 SESETSTMAAK 11 0 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 SES(0.896)ET(0.009)S(0.025)T(0.07)MAAK 156.36 0.00054628 10291000.0 34783.0 36952.0 32095.0 35364.0 47306.0 34454.0 32301.0 36380.0 28014.0 41875.0 True False 32849.90010738125 39786.09958059294 30030.04264239384 30547.362193697318 41362.99735899418 39199.72575772816 33803.06050321725 36485.8597769668 33617.582776559524 40665.95994568377 0.8077984671026534 0.9783637133792974 0.7384565047155905 0.7511776983624254 1.0171405621370164 0.9639444343644167 0.8312372448201624 0.8972088652450305 0.8266762378525297 1.0 15.311534049576355 -6.250012848676958 24.95996803285224 0.9150506322519899 0.8245863902749957 0.2606670828118889 0.08480501287757819 1251.321085400275 2733368.4304513917 0.026219393937010886 0.033559040412536566 5.623246884716061e-07 6.250012848676958 -0.09046424197699421 SES(ph)FANY(ph)IDEREKS(ph)ISELSDQY(ph)KQEK ddPTM_A459_Selumetinib_30min_R1 1 SESFANYIDEREKSISELSDQYKQEK 26 3 P49454 P49454 CENPF Centromere protein F 4 S(0.197)ES(0.834)FANY(0.963)IDEREKS(0.503)IS(0.503)ELS(0.481)DQY(0.518)KQEK 43.88800000000001 0.02907 8009700.0 292.37 303.71 279.44 327.22 368.88 538.19 388.76 322.89 183.2 445.54 True False 299.18165214701213 268.1514920090515 241.49358285404693 270.07716968013744 335.51486913105344 532.7762972374226 359.43552020752816 314.3259083054651 310.8770196014003 502.72939892711065 0.5951146934822279 0.5333913086867833 0.48036495054680584 0.5372217544001145 0.6673866096693081 1.0597675377139986 0.7149681736827206 0.6252387645844406 0.618378436321512 1.0 8.973638248106152 -6.521572061239576 24.99990469125512 0.7845788764062096 0.5410401454952475 0.4567816682830592 0.136627664875593 52.075843859749526 996359.2235671275 0.04693275027518422 0.04755368961870168 3.009039846084885e-07 6.521572061239576 -0.24353873091096212 SES(ph)FSSEDLIPSR ddPTM_A459_Selumetinib_30min_R1 2 SESFSSEDLIPSR 13 0 Q9P219;A0A0A0MR69;Q9P219-3;Q9P219-2 Q9P219 CCDC88C Protein Daple 1 S(0.044)ES(0.915)FS(0.039)S(0.002)EDLIPSR;S(0.069)ES(0.926)FS(0.004)SEDLIPSR 128.96 0.0017734000000000005 9288400.0 1485.65 2021.31 1948.7800000000002 2246.46 1902.5300000000002 1960.87 1907.91 1621.0 824.02 1215.13 True False 1520.2627544283237 1784.6540855184746 1684.146379882299 1854.1579322768828 1730.446497418954 1941.145428127508 1763.994812632846 1578.0058142499267 1398.3017559604023 1371.1037718685193 1.1087875225932262 1.3016185369298308 1.228314307375269 1.3523104307050842 1.2620828072412988 1.41575383858958 1.2865509152738315 1.1509018111002967 1.019836561352915 1.0 10.421122050158887 -8.035739041350807 2.470446457486351 1.006333869278525 1.2856465907230585 0.6702703206665913 0.07570558252536626 0.17726073508837742 2.0055696831984435 0.06221565712797366 0.020909804565054885 9.21002817227783e-09 8.035739041350807 0.27931272144453345 SES(ph)FSSEDLIPSR ddPTM_A459_Selumetinib_30min_R2 1 SESFSSEDLIPSR 13 0 Q9P219;A0A0A0MR69;Q9P219-3;Q9P219-2 Q9P219 CCDC88C Protein Daple 1 S(0.019)ES(0.98)FSSEDLIPSR 141.54 0.00082341 1832000.0 14336.0 8192.3 15570.0 13554.0 14269.0 9583.9 11377.0 10532.0 11324.0 11726.0 True False 13539.262511554998 8820.623067603688 14568.243151334227 11707.921818045843 12476.4006535215 10903.9952310179 11906.05304309782 10562.646376333536 13589.116418996226 11387.439912193135 1.1889645623559157 0.7745922819894734 1.2793255783273323 1.0281434552738717 1.0956282316065051 0.9575457973958146 1.0455425569665908 0.92756988908662 1.1933425356164242 1.0 13.475155820965606 -6.725758605725234 24.976975148530162 1.0215694196513019 1.0656679577530128 0.028146766700309245 0.13833412477723256 897.981517580644 628595.6131321662 0.04338549329438272 0.04338377886925739 1.8803616894424788e-07 6.725758605725234 0.04409853810171094 SES(ph)GGSEYGTGPGR ddPTM_A459_Selumetinib_30min_R1 1 SESGGSEYGTGPGR 14 0 A0A5F9ZHX5;Q12873-2;Q12873;Q12873-3 A0A5F9ZHX5;Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 S(0.144)ES(0.856)GGSEYGTGPGR 185.66 7.9994e-05 3310800.0 590.29 652.09 525.03 512.19 554.95 616.34 669.68 610.89 270.68 412.18 True False 604.0426084956043 575.7429996515838 453.7338097833531 422.7456314970649 504.7548704843804 610.1401791919453 619.1654984375391 594.6872127496225 459.32419031499455 465.08731797319336 1.2987724780971561 1.237924530302433 0.9755884373727545 0.9089597053287767 1.085290548630856 1.3118830714431833 1.3312887161400226 1.2786571247335086 0.9876085039615486 1.0 8.861357790685126 -6.720121561298441 24.889387163048028 1.208641221581049 1.091226513242261 0.04930195826160588 0.15304064193962308 337.4771484049189 203291.37048530785 0.05383601137273978 0.05383544578165622 1.9049274441722697e-07 6.720121561298441 -0.11741470833878798 SES(ph)LDPDSSMDTTLILK ddPTM_A459_Selumetinib_30min_R1 2 SESLDPDSSMDTTLILK 17 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 S(0.004)ES(0.996)LDPDSSMDTTLILK;SES(0.999)LDPDS(0.001)SMDTTLILK 235.78 1.4039e-17 12190800.0 5306.9 5734.7 6332.1 7825.5 5552.5 5010.7 5619.9 5526.5 2338.0 4006.7 True False 5430.540444570165 5063.2786580103 5472.235599735577 6458.923327828112 5050.277355373495 4960.296907351588 5195.986418392552 5379.9192673980415 3967.4152392362084 4520.998973562989 1.2011815256596639 1.1199468718348198 1.2104040792167934 1.4286495895259737 1.1170711130229218 1.0971683330072488 1.1493005083116856 1.1899846248268753 0.8775527847796651 1.0 12.142425874772917 -8.252869933524329 24.82071277344526 0.9387763895729864 1.1887886902475446 0.5399814257089453 0.09245992026148328 402.2017761735804 1164954.6150283264 0.0684061419227153 0.02492414575168051 5.586374755365951e-09 8.252869933524329 0.25001230067455826 SES(ph)LELPQAAPPQIYHEK ddPTM_A459_Selumetinib_30min_R2 1 SESLELPQAAPPQIYHEK 18 0 B0QY58;B0QY55;B0QY57;B0QY56;H0YGT9;Q15040 B0QY58 JOSD1 Josephin-1 1 S(0.208)ES(0.792)LELPQAAPPQIYHEK 114.78 0.00071254 3179200.0 21549.0 21292.0 21404.0 25807.0 24024.0 19777.0 21319.0 21028.0 19102.0 24677.0 True False 20351.392847481773 22925.027935429327 20026.88994291316 22292.04208044186 21005.890342715 22501.102232268804 22310.37574279707 21089.1879986272 22922.933754474212 23964.510891454036 0.849230469992161 0.9566240696197393 0.8356894924175119 0.9302106010597282 0.876541584255988 0.9389343406250324 0.9309756349232713 0.8800174597407618 0.9565366828600178 1.0 14.548611874829732 -14.522878574922856 0.12979368855015286 1.328406851023889 0.8656076514269665 0.4172444432259108 0.038213956037070576 141.5963572019091 1.155832737890911 11.963020571361156 0.27235811895094353 3.0000011767880207e-15 14.522878574922856 -0.4627991995969224 SES(ph)LIDASEDSQLEAAIR ddPTM_A459_Selumetinib_30min_R1 1 SESLIDASEDSQLEAAIR 18 0 C9JAT7;O94888 C9JAT7 UBXN7 UBX domain-containing protein 7 1 S(0.148)ES(0.846)LIDAS(0.004)EDS(0.002)QLEAAIR 130.01 0.00079471 0.0 0.0 160.39 280.73 165.75 0.0 158.37 160.85 0.0 93.576 175.76 True False 0.0 141.6114642367119 242.6084079395095 136.8048740128439 0.0 156.776941588455 148.7169549989221 0.0 158.79163747937017 198.3205080473784 0.0 0.7140535571988409 1.2233147763092196 0.6898170812479033 0.0 0.7905230938143889 0.7498818778912864 0.0 0.8006818812779318 1.0 7.631690062139421 -8.518572336200796 24.72351852234517 1.0000001052511969 0.5459701094395156 0.1402071283417745 0.38773393547633767 573.1661755559858 3290594.7215806055 0.3826812926616906 0.0988078851001341 3.029895595566856e-09 8.518572336200796 -0.45402999581168124 SES(ph)LSNCSIGK ddPTM_A459_Selumetinib_30min_R1 1 SESLSNCSIGK 11 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.001)ES(0.768)LS(0.228)NCS(0.002)IGK 124.48 0.0035592 28506000.0 3197.5 4678.8 3252.4 4053.4 4119.1 3729.6 4391.6 3815.7 2054.5 3871.2 True False 3271.995528748064 4131.003920884891 2810.741944154387 3345.549781741547 3746.52813228617 3692.0836102058556 4060.338076302558 3714.4952408596246 3486.336445256968 4368.106228681222 0.7490650083699806 0.9457196562117688 0.6434692283120093 0.7659039424853008 0.857700782935695 0.8452366808214129 0.9295419716769153 0.8503674238666742 0.7981345376551271 1.0 12.092792226480306 -6.36885898549814 4.021294487606601 0.8757065558683995 0.7789445191326437 0.26276722153261933 0.08558577238870817 0.3760099270288718 10.639347381041587 0.027190904122183567 0.031147644850114495 4.2770173745965323e-07 6.36885898549814 -0.09676203673575579 SES(ph)LSNCSIGK ddPTM_A459_Selumetinib_30min_R2 2 SESLSNCSIGK 11 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.001)ES(0.938)LS(0.037)NCS(0.025)IGK;S(0.205)ES(0.784)LS(0.01)NCS(0.001)IGK 137.62 0.0013177 36454000.0 71911.0 57033.0 62126.0 62054.0 58215.0 49005.0 52814.0 54723.0 42643.0 50265.0 True False 67914.4745025413 61407.247710000986 58128.880797674385 53602.13815087922 50901.511251296804 55754.993926901654 55269.95564895561 54882.23487011965 51172.7915449714 48813.71884584583 1.3912989239155458 1.2579915884697421 1.190830819123737 1.0980957693503184 1.0427706074196936 1.1421992678528843 1.1322627522704967 1.1243198872726385 1.0483280674962614 1.0 15.574999046382123 -4.941863163657893 1.075084007874106 1.0893980705274013 1.4875206024111558 0.8366266540936663 0.04411129392517686 0.5443546155439083 0.6219711152079419 0.01456099794761415 0.23297667730819716 1.1432384865691644e-05 4.941863163657893 0.39812253188375446 SES(ph)LSNCSIGKK ddPTM_A459_Selumetinib_30min_R1 1 SESLSNCSIGKK 12 1 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.186)ES(0.407)LS(0.407)NCSIGKK 103.14 0.019705 11364000.0 768.9 845.35 1248.1 1516.7 1043.6 788.58 975.38 948.97 518.51 710.78 True False 786.8138739810432 746.376029007447 1078.6148753225586 1251.8368169851 949.2065642625448 780.6476011733522 901.8063013170572 923.8002329110138 879.8735995279585 802.0155365834984 0.981045675664573 0.9306253993369382 1.344880274910065 1.5608635492496727 1.183526404371248 0.9733572051469584 1.1244249770505157 1.1518483006530091 1.097077998359143 1.0 9.647486374503371 -6.543098076467537 23.84889348401183 1.081848934783807 1.2170087587202085 0.12293353528680184 0.17253854796942625 352.76082473877625 416080.1473618042 0.0639424237330906 0.06395166136176468 2.863531227308918e-07 6.543098076467537 0.13515982393640158 SES(ph)MPVQLNK ddPTM_A459_Selumetinib_30min_R1 1 SESMPVQLNK 10 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 S(0.01)ES(0.99)MPVQLNK 151.13 0.00068378 11606000.0 3180.5 4229.6 4384.3 4313.3 4187.2 3270.4 4125.7 4278.4 1710.4 3620.0 True False 3254.599461824308 3734.396465712309 3788.9361412360354 3560.063125668776 3808.468499310201 3237.5027452856175 3814.495127379875 4164.922933798203 2902.4238773266093 4084.6622617860135 0.7967854508493044 0.9142485293458384 0.9276008390420333 0.8715685404335346 0.9323827174012064 0.7925998620679163 0.933858146135194 1.0196492798836925 0.7105664290730191 1.0 11.996001079461436 -10.60027195829982 4.045918089404093 1.0000200191388329 0.8849908030933732 0.15213489309379225 0.08506399680956835 114370931.91036598 131413430.34762216 28546.74599645003 0.020096886551051758 2.51031396272072e-11 10.60027195829982 -0.11502921604545968 SES(ph)MPVQLNK ddPTM_A459_Selumetinib_30min_R2 4 SESMPVQLNK 10 0 C9J3F6;Q92609;Q92609-2 C9J3F6;Q92609 TBC1D5 TBC1 domain family member 5 1 S(0.001)ES(0.999)MPVQLNK;S(0.002)ES(0.998)MPVQLNK;S(0.003)ES(0.997)MPVQLNK;SES(1)MPVQLNK 148.78 0.00077327 72516100.0 263936.0 179857.0 238036.0 276233.0 298229.0 147750.0 207974.0 267133.0 155269.0 167792.0 True False 249267.4937395214 193651.45356859485 222721.02291400143 238609.5888714961 260762.80681891282 168101.22135903928 217645.2030926628 267910.3128037512 186327.13857833995 162947.40898402766 1.5297419903372318 1.18842916727554 1.3668276427508759 1.4643349677004374 1.600288144774816 1.031628685642475 1.335677593462052 1.6441520271734555 1.1434802169613143 1.0 17.314046886497252 -6.74489100685828 24.999842746530597 1.2777902070944362 1.4149142151014982 0.17952538577671395 0.1992418854891702 619.3025920319866 935586.458376317 0.06691753402172965 0.0667405610377333 1.7993224271916605e-07 6.74489100685828 0.13712400800706193 SES(ph)PDLILHDSGVSAAR ddPTM_A459_Selumetinib_30min_R2 2 SESPDLILHDSGVSAAR 17 0 P0CG40 P0CG40 SP9 Transcription factor Sp9 1 S(0.262)ES(0.738)PDLILHDSGVSAAR;S(0.167)ES(0.833)PDLILHDSGVSAAR 106.39 0.0016904 6378700.0 13109.0 13271.400000000001 26498.0 44061.0 49159.0 25507.0 14525.5 19507.2 23334.0 34301.0 True False 12380.454259484826 14289.273705723128 24793.14752884101 38059.815790535504 42983.206932964 29020.357720507705 15200.96453173221 19563.962722409196 28001.45200643393 33310.64100529905 0.3716666472288944 0.42897024117458427 0.7443011236228364 1.1425723024807886 1.2903746561384466 0.8712038209018901 0.4563395981876796 0.5873187105374816 0.8406158260953149 1.0 15.023695495983455 -5.317257395734097 3.6022828463893832 0.8693275084043424 0.38854614328342163 0.40808061892164027 0.22887790554737042 0.26386906276873945 6.890780013977693 0.07145262822941431 0.17641070618037985 4.8166224356329885e-06 5.317257395734097 -0.48078136512092073 SES(ph)PEPAATCSLPSDLTR ddPTM_A459_Selumetinib_30min_R2 4 SESPEPAATCSLPSDLTR 18 0 Q9NS37;E9PIM0 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 S(0.01)ES(0.99)PEPAATCSLPSDLTR;S(0.007)ES(0.992)PEPAAT(0.001)CSLPSDLTR;SES(1)PEPAATCSLPSDLTR;S(0.002)ES(0.968)PEPAAT(0.024)CS(0.006)LPSDLTR 247.44 8.637899999999998e-33 13778600.0 44524.9 28982.5 39886.600000000006 46843.2 46001.2 34630.0 46188.3 41821.600000000006 40157.899999999994 34581.2 True False 42050.38430529685 31205.36455657435 37320.339581246495 40463.075350972795 40222.1180000542 39399.96816015925 48336.14747038015 41943.293932061395 48190.60210547583 33582.75090325202 1.2521423401685912 0.929208111821255 1.111294893285009 1.2048767376901965 1.1977017045425917 1.1732203914344588 1.4393147127711767 1.248953489632077 1.4349807805890389 1.0 15.035432791835358 -6.304547418064331 1.1390554418705552 1.2903516271532884 1.083740521727738 0.17894433433733692 0.14024078879675245 0.6640062857076376 1.7892581814160977 0.05780621732708074 0.08215260983235396 4.95966772739982e-07 6.304547418064331 -0.2066111054255504 SES(ph)PFRETEPLVSPHQDK ddPTM_A459_Selumetinib_30min_R2 2 SESPFRETEPLVSPHQDK 18 1 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 S(0.225)ES(0.75)PFRET(0.025)EPLVS(0.001)PHQDK;S(0.136)ES(0.857)PFRET(0.008)EPLVSPHQDK 132.76 0.00025746 13552500.0 42737.0 38555.0 53188.0 61769.0 57271.0 45167.0 34686.0 37960.0 34908.0 50610.0 True False 40361.84862976608 41512.04452613556 49765.94198671582 53355.95564253166 50076.10497076391 51388.34426479675 36298.9677290051 38070.45731538371 41890.57541101381 49148.75779942817 0.8212180823466443 0.8446204214467155 1.0125574727606816 1.0856013057394596 1.0188681710964125 1.0455675090407808 0.7385531060039817 0.7745965314270191 0.8523221600424903 1.0 15.584867333465217 -7.258389557478335 24.98442806222093 0.8225843272785955 0.9748611931673847 0.2753273734932975 0.10144653347154295 334.1415854935106 2737332.944124481 0.04273895010942114 0.03166041194267462 5.51582453788227e-08 7.258389557478335 0.1522768658887892 SES(ph)PIPVAEQGTLMR ddPTM_A459_Selumetinib_30min_R1 3 SESPIPVAEQGTLMR 15 0 P86452 P86452 ZBED6 Zinc finger BED domain-containing protein 6 1 SES(1)PIPVAEQGTLMR;S(0.013)ES(0.987)PIPVAEQGTLMR;S(0.009)ES(0.991)PIPVAEQGTLMR 270.99 5.6185e-45 47955700.0 5404.5 6076.200000000001 6315.5 6044.299999999999 6442.7 5303.3 6102.3 5493.1 3224.0299999999997 4818.0 True False 5530.414334673627 5364.79567925126 5457.889788558307 4988.776470563088 5859.958922551072 5249.953617011131 5641.998598010085 5347.405143896533 5470.943436165406 5436.437231294201 1.0172865241298947 0.9868219664837579 1.0039460691536393 0.9176554898575472 1.07790427319181 0.9656974583998507 1.0378117796583015 0.983623081880691 1.0063472092848922 1.0 12.408445775729339 -6.2587284902521585 24.995006003617277 1.0100641840993214 0.983421305164859 0.13488447532102954 0.03749623546195597 566.5560219927759 5223778.591685006 0.010739908053891554 0.013209761778949742 5.511521548824011e-07 6.2587284902521585 -0.026642878934462377 SES(ph)PIPVAEQGTLMR ddPTM_A459_Selumetinib_30min_R2 3 SESPIPVAEQGTLMR 15 0 P86452 P86452 ZBED6 Zinc finger BED domain-containing protein 6 1 S(0.015)ES(0.985)PIPVAEQGTLMR;S(0.028)ES(0.972)PIPVAEQGTLMR;S(0.001)ES(0.999)PIPVAEQGTLMR 252.01 3.4763999999999996e-28 39163700.0 88494.9 74579.3 89716.7 97090.0 99295.6 74603.2 77801.3 75857.4 67897.5 79898.7 True False 83576.70773115294 80299.29249975421 83944.42519815726 83866.17451040813 86821.1990140731 84879.1136195781 81419.21461035134 76078.13247513144 81478.89721465892 77591.81692924668 1.0771330152941732 1.034893828726506 1.0818721421964292 1.0808636506976352 1.1189478794296361 1.0939183663784604 1.049327336729268 0.9804916998464476 1.0500965235671273 1.0 16.24361688894504 -7.533493166725187 5.4983375283377995 1.0114758805338246 1.0803541500976985 0.6148624398995837 0.025201844975797884 0.11953692813602224 11.950567258139332 0.01232293637952749 0.007315753682301202 2.927566933921111e-08 7.533493166725187 0.06887826956387388 SES(ph)PKEPEQLR ddPTM_A459_Selumetinib_30min_R1 6 SESPKEPEQLR 11 1 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.028)ES(0.972)PKEPEQLR;S(0.145)ES(0.855)PKEPEQLR;S(0.008)ES(0.992)PKEPEQLR;SES(1)PKEPEQLR;S(0.03)ES(0.97)PKEPEQLR;S(0.069)ES(0.931)PKEPEQLR 174.46 0.00061989 3729219600.0 28995.799999999996 36311.3 33207.9 34452.49999999999 27276.3 29839.800000000003 30462.399999999998 28113.1 20377.75 30218.39 True False 29671.345723994724 32059.956115334608 28698.44957793767 28436.017628521873 24809.163481021886 29539.638704370635 28164.596642581044 27367.449263781386 34579.55341802641 34097.21470854472 0.8701985184895211 0.9402514659738592 0.8416655091404247 0.8339689288871985 0.7276008815700932 0.8663358270424368 0.826008718991438 0.8026300534431375 1.014145985635619 1.0 15.05736627450894 -8.267501188179564 24.953168925764516 1.0070730271540582 0.8387270338622037 0.635923464384798 0.05099510918344549 349.945613418945 1440512.8209956563 0.04837165539305704 0.013764493304199628 5.40130637027548e-09 8.267501188179564 -0.1683459932918545 SES(ph)PKEPEQLR ddPTM_A459_Selumetinib_30min_R2 1 SESPKEPEQLR 11 1 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 SES(1)PKEPEQLR 139.74 0.0054271 308900000.0 37453.0 32158.0 34319.0 30737.0 31598.0 24992.0 33658.0 27098.0 23698.0 26245.0 True False 35371.51219623811 34624.41519573252 32110.952903701946 26550.56757571751 27628.376750295898 28434.421145212233 35223.16369206175 27176.850693684606 28438.262177443696 25487.23865730078 1.3878126489825133 1.3585000580600133 1.2598835572367435 1.0417200518547403 1.084008241213757 1.1156336521009207 1.381992147743794 1.0662924712677668 1.115784356234982 1.0 14.637487456667273 -5.50556336770105 3.593140723354814 1.1278360500504458 1.368066491404459 0.5302140251627336 0.09793175650679442 0.1931521959587894 5.287946858964336 0.027898543327334508 0.0582733273127624 3.1220268395388286e-06 5.50556336770105 0.24023044135401306 SES(ph)PKEPEQLRK ddPTM_A459_Selumetinib_30min_R2 1 SESPKEPEQLRK 12 2 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8W646 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.195)ES(0.805)PKEPEQLRK 54.343 0.045433 2151000000.0 160360.0 141650.0 131780.0 126610.0 86981.0 73867.0 101640.0 80743.0 44323.0 105450.0 True False 151447.83317194192 152514.09952346238 123301.41827121547 109365.49958556783 76053.66915999388 84041.50875213643 106366.46139583923 80977.94876227686 53188.83848809341 102405.38450799629 1.4789049804321195 1.4893171902650624 1.2040521000298332 1.0679662999266222 0.7426725608755002 0.8206747052990566 1.0386803575502774 0.7907587003489424 0.5193949394715682 1.0 16.643932049137547 -5.678426843683172 1.4099620934821857 0.8164329306917453 1.5126458256039106 0.7810701528523911 0.1393797634342576 0.20560470680708437 0.8039462042108092 0.04698543838080133 0.12530971412462716 2.0968779667955987e-06 5.678426843683172 0.6962128949121653 SES(ph)PPAELPSLR ddPTM_A459_Selumetinib_30min_R1 4 SESPPAELPSLR 12 0 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.004)ES(0.996)PPAELPSLR;S(0.01)ES(0.99)PPAELPSLR;S(0.197)ES(0.803)PPAELPSLR;S(0.225)ES(0.775)PPAELPSLR 182.41 0.00010389 438889000.0 12579.2 19809.800000000003 12964.2 14987.599999999999 14182.7 13711.3 15113.5 12488.599999999999 6770.0 11517.400000000001 True False 12872.270885137657 17490.459406673843 11203.732847253199 12370.297012095927 12899.877289159065 13573.376770864314 13973.476527051342 12157.361759310077 11488.195538763528 12995.770478976307 0.9904969394436106 1.3458578262034364 0.8621060879289807 0.9518709977302054 0.9926212001071909 1.0444457135359861 1.075232634314118 0.9354860320884744 0.8839949549238629 1.0 13.66575454881527 -5.273862724118674 24.996624662527022 0.9727474824700844 1.168177403273244 0.38514749239839696 0.1009281899650163 666.8914218014867 1341831.691131929 0.025736811671434354 0.05419481164812343 5.322764796310567e-06 5.273862724118674 0.19542992080315957 SES(ph)PPAELPSLR ddPTM_A459_Selumetinib_30min_R2 1 SESPPAELPSLR 12 0 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.024)ES(0.976)PPAELPSLR 179.6 0.00010389 142850000.0 46687.0 44997.0 55085.0 53091.0 61794.0 42457.0 47686.0 51074.0 43321.0 47084.0 True False 44092.32344286891 48448.12521184076 51540.891072013226 45859.91421291661 54030.88527463088 48305.06636372743 49903.49348801642 51222.61688424413 51986.410489874186 45724.562581076374 0.9643027938143035 1.0595645420540678 1.1272035895504444 1.0029601514853255 1.1816599705864035 1.0564358331055752 1.091393567724791 1.1202429064995187 1.1369471364038668 1.0 15.480681748208397 -4.806083377959173 3.1715793313130423 1.0931468741046106 0.9489520016981283 0.3191769386405747 0.054668510890077654 0.35241444615918627 5.537009134575285 0.012995328376553227 0.1238452881390424 1.5628475707872447e-05 4.806083377959173 -0.14419487240648232 SES(ph)PPAELPSLRR ddPTM_A459_Selumetinib_30min_R1 2 SESPPAELPSLRR 13 1 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.005)ES(0.995)PPAELPSLRR;S(0.194)ES(0.806)PPAELPSLRR 139.66 0.00047382 47778000.0 5656.5 5131.8 13127.8 13303.2 8738.1 7047.5 6667.200000000001 5929.9 4065.5 4334.799999999999 True False 5788.285444366983 4530.966470290904 11345.116865843669 10980.04585199194 7947.740397836856 6976.608548618025 6164.287736206484 5772.619788970168 6898.8565676282315 4891.213804527626 1.1834047080520114 0.9263480705130384 2.319489051028988 2.2448509287874705 1.624901448895959 1.426355262196885 1.2602777107188439 1.1802018925499955 1.4104590073822167 1.0 12.255976813739762 -6.9538198223579855 2.643909274108826 1.2305138545554406 1.688316644734205 0.21277008326381486 0.4043121476778065 0.5137459266547135 7.28178779593132 0.1819743230910213 0.15022974137839218 1.1121930519514748e-07 6.9538198223579855 0.45780279017876446 SES(ph)PPAELPSLRR ddPTM_A459_Selumetinib_30min_R2 1 SESPPAELPSLRR 13 1 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.192)ES(0.808)PPAELPSLRR 60.657 0.047342 4110600.0 7549.6 12482.0 12583.0 11952.0 17209.0 9249.6 7662.4 7518.9 5125.6 10960.0 True False 7130.023455443337 13439.329264044196 11773.423479334528 10324.116981649991 15047.051569588015 10523.648440491164 8018.716782757555 7540.7787541790985 6150.863221229867 10643.556322500152 0.66989108145843 1.2626728188240868 1.1061550409091998 0.9699875369499502 1.4137240517794798 0.9887342276983582 0.7533869826766674 0.7084830037717866 0.577895492339072 1.0 13.377692657417022 -7.185333886339874 3.9167326783088456 0.7334410546191302 1.0972388692199009 0.35063317232034563 0.20627713939543016 0.23455626111477745 6.901872918758104 0.08091075360746773 0.06042939937595222 6.526286177313634e-08 7.185333886339874 0.36379781460077065 SES(ph)PPPLSDPK ddPTM_A459_Selumetinib_30min_R1 4 SESPPPLSDPK 11 0 Q15059;Q15059-2 Q15059 BRD3 Bromodomain-containing protein 3 1 SES(1)PPPLSDPK;S(0.079)ES(0.921)PPPLSDPK;S(0.399)ES(0.601)PPPLSDPK;S(0.016)ES(0.984)PPPLSDPK 184.87 2.2726e-05 632400000.0 25434.1 30603.699999999997 32722.2 33725.2 29322.7 26606.4 29303.0 26790.4 15258.599999999999 23814.6 True False 26026.665043856505 27020.604576725873 28278.704970178555 27835.726920410023 26670.466962343144 26338.763772678318 27092.651118019356 26079.831564516513 25892.729755949385 26871.435883847847 0.9685624972315259 1.0055511991812722 1.0523704461649779 1.0358853557632848 0.992521094802176 0.9801770134848018 1.0082323562882056 0.9705410487644555 0.9635781976025051 1.0 14.713785793835356 -6.444244142427335 6.180138912258578 0.9843491753830322 1.017389266550595 0.28048871800183217 0.02355237535167377 0.32083796940787446 20.23692007593146 0.007928316778998851 0.008947071088144923 3.5954715576599626e-07 6.444244142427335 0.03304009116756279 SES(ph)PPPLSDPK ddPTM_A459_Selumetinib_30min_R2 4 SESPPPLSDPK 11 0 Q15059;Q15059-2 Q15059 BRD3 Bromodomain-containing protein 3 1 S(0.168)ES(0.832)PPPLSDPK;S(0.005)ES(0.995)PPPLSDPK;SES(1)PPPLSDPK;S(0.001)ES(0.999)PPPLSDPK 182.23 3.7626e-05 523349000.0 484513.0 433333.0 467837.0 470344.0 478403.0 360881.0 379024.0 439537.0 322090.0 434062.0 True False 457585.70711921377 466568.247714795 437736.87676241086 406282.3358113444 418301.73816291615 410589.08199845295 396649.3670218082 440815.9799007326 386516.9999465297 421529.5022314837 1.0855366105974944 1.106846010172209 1.0384489684473541 0.9638289459233003 0.9923427327115173 0.9740458967281896 0.9409765269620144 1.0457535654495131 0.9169393788581687 1.0 18.68527408124728 -5.52671012675253 3.1421056857606255 0.9773502044823031 1.0952659469553474 0.6796902452080618 0.033150365370733965 0.13094098481743133 2.647615344446635 0.008621611297517935 0.01819768384576109 2.973650155550644e-06 5.52671012675253 0.11791574247304426 SES(ph)PQKEDGLSSQLK ddPTM_A459_Selumetinib_30min_R2 1 SESPQKEDGLSSQLK 15 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 S(0.005)ES(0.995)PQKEDGLSSQLK 135.23 0.0030104 0.0 13966.0 10741.0 10389.0 13054.0 12420.0 10803.0 14272.0 14810.0 10128.0 9960.6 True False 13189.825630327652 11564.800162241525 9720.583050687941 11276.022680593955 10859.688563791227 12291.015190129958 14935.676279431491 14853.094648072522 12153.882999964128 9673.011597253198 1.3635697112234526 1.195573896088942 1.00491795682828 1.1657199587971088 1.1226791630101016 1.2706503105630704 1.5440564842983036 1.535519160577693 1.2564735271707326 1.0 13.239749413246743 -6.999368969211132 6.949461283456258 1.3829433814852148 1.1651545946629571 0.15252854163307705 0.16723994610082382 0.18218714172060552 51.27298035616764 0.06017424828335269 0.05058894179229642 1.0014540582066529e-07 6.999368969211132 -0.21778878682225766 SES(ph)PSLTQER ddPTM_A459_Selumetinib_30min_R2 1 SESPSLTQER 10 0 Q9BXW9;H7BZJ7;Q9BXW9-3;Q9BXW9-1 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 S(0.11)ES(0.74)PS(0.002)LT(0.149)QER 141.71 0.0012789 12661000.0 48682.0 35369.0 47749.0 51293.0 58960.0 36852.0 46772.0 40676.0 42424.0 49417.0 True False 45976.449329486655 38081.68857074019 44676.88132518036 44306.80491463964 51552.9176909123 41928.02849085152 48946.99067695976 40794.360425725725 50909.985425600105 47990.20280921442 0.958038237768374 0.7935304779213866 0.9309583771253019 0.9232468779259349 1.0742383793596684 0.8736789185396207 1.0199371499126408 0.8500560122219978 1.0608412226969184 1.0 15.550452289524365 -5.68951774943311 2.6594545805079384 0.9694053242685577 0.8753684322996886 0.18724796135279975 0.07886566279246611 0.4215859989429569 6.02918997928104 0.02127955594231112 0.040655212947983216 2.044006396612157e-06 5.68951774943311 -0.09403689196886911 SES(ph)PVCSSR ddPTM_A459_Selumetinib_30min_R1 1 SESPVCSSR 9 0 O00472;D6RC27 O00472 ELL2 RNA polymerase II elongation factor ELL2 1 SES(0.812)PVCS(0.186)S(0.002)R 100.82 0.017575 789060.0 500.97 387.59 524.16 615.67 491.66 401.66 542.13 397.62 226.11 331.34 True False 512.6416262820698 342.21078261429756 452.98195100478506 508.15479205724057 447.1894398096232 397.6196650781008 501.2366976286329 387.0738259482148 383.692155578999 373.87071652491124 1.371173519678191 0.9153184977820958 1.2116005105058891 1.3591724882346647 1.1961071569504071 1.0635218205210977 1.3406685131362386 1.0353146390977743 1.0262696130506743 1.0 8.546395666109204 -7.89844509619374 9.897542996778926 1.019074273920483 1.1967700190708137 0.2951038686795524 0.13233057745614418 0.4155983642676449 36.722397679903764 0.0716555589519228 0.03437779769062828 1.2634408187663372e-08 7.89844509619374 0.1776957451503307 SES(ph)PVCSSR ddPTM_A459_Selumetinib_30min_R2 2 SESPVCSSR 9 0 O00472;D6RC27 O00472 ELL2 RNA polymerase II elongation factor ELL2 1 S(0.071)ES(0.927)PVCSS(0.001)R;S(0.03)ES(0.97)PVCSSR 123.51 0.0035817 8119800.0 33741.0 29564.0 34216.0 40425.0 33791.0 27892.0 31473.0 39494.0 30565.0 37595.0 True False 31865.81029592477 31831.463736757145 32014.579811564032 34919.04526298536 29545.872484627154 31733.869821633307 32936.55686256636 39608.92100141632 36678.854057454904 36509.53466645923 0.8728079003756632 0.8718671445023988 0.8768827130786565 0.9564363277153728 0.8092645593692135 0.8691940368877598 0.9021357616158469 1.0848925181674378 1.004637675953488 1.0 15.15598566051973 -7.66336874793403 5.868479805766063 1.0326994296787406 0.8774891702949144 0.7511169803978474 0.03972766441886603 0.09659605975392364 4.790075355128718 0.01898144201664572 0.010723810005447032 2.170857178834669e-08 7.66336874793403 -0.15521025938382627 SES(ph)PVPQNEK ddPTM_A459_Selumetinib_30min_R1 2 SESPVPQNEK 10 0 Q9UIF8-4;Q9UIF8-2;Q9UIF8-5;Q9UIF8-3;Q9UIF8 Q9UIF8-4 BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 1 S(0.014)ES(0.986)PVPQNEK;S(0.01)ES(0.99)PVPQNEK 132.86 0.0023684 21721400.0 8894.2 8758.6 10637.0 10409.7 10053.8 7869.8 9483.3 8565.4 5602.7 8718.5 True False 9101.41755489947 7733.139040237327 9192.553824858629 8591.841309269996 9144.43556514255 7790.636957206688 8767.967045951365 8338.217767659671 9507.372694982345 9837.60440038159 0.9251660449515978 0.7860794890204538 0.934430116391147 0.8733672304343452 0.9295388585444488 0.7919241961899279 0.8912705460702675 0.8475862037445052 0.9664316949575208 1.0 13.264091325789309 -8.391975151461882 4.141773405274714 0.9981997219923605 0.8716267397113897 0.44519947489544265 0.049966915899905595 0.18842201847381942 5.046319127277884 0.04491907089584956 0.011819873205012477 4.05531737637193e-09 8.391975151461882 -0.1265729822809708 SES(ph)PVPQNEK ddPTM_A459_Selumetinib_30min_R2 2 SESPVPQNEK 10 0 Q9UIF8-4;Q9UIF8-2;Q9UIF8-5;Q9UIF8-3;Q9UIF8 Q9UIF8-4 BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 1 S(0.135)ES(0.865)PVPQNEK;S(0.003)ES(0.997)PVPQNEK 158.34 0.00047709 21395000.0 171155.0 144446.0 159742.0 180240.0 177576.0 129437.0 149346.0 171458.0 128162.0 153535.0 True False 161642.89028775092 155524.54373290527 149464.37363393922 155691.0010686574 155267.31533041783 147265.77183790162 156290.88492348496 171956.91439360016 153797.98114547785 149102.04561816272 1.0841091389296174 1.0430745137540902 1.0024300673694604 1.04419091249337 1.0413493301630738 0.9876844494477048 1.048214223188676 1.1532834018519555 1.0314947759961726 1.0 17.18594052537094 -7.532318900854444 24.974018959888152 1.0755832074890148 1.0323107737393484 0.04703398200776787 0.044271953443908295 369.8178744505612 978342.1799139745 0.01993144640740511 0.011527066327631494 2.9354933383174917e-08 7.532318900854444 -0.043272433749666384 SES(ph)SQGGAAGGPEAGAR ddPTM_A459_Selumetinib_30min_R2 1 SESSQGGAAGGPEAGAR 17 0 Q6ZN16 Q6ZN16 MAP3K15 Mitogen-activated protein kinase kinase kinase 15 1 S(0.026)ES(0.487)S(0.487)QGGAAGGPEAGAR 122.1 0.0011467 0.0 11323.0 5805.4 7847.6 6856.1 6709.8 8512.0 8038.3 8723.1 5417.5 6755.7 True False 10693.712989560361 6250.655512696858 7342.693959820843 5922.287352567813 5866.854937626925 9684.450735757298 8412.096877589272 8748.482776813054 6501.151377597317 6560.645387583423 1.6299788142488418 0.9527500944536269 1.1192029939184813 0.9026988966323715 0.8942496646336723 1.4761429956397187 1.2822056948101292 1.3334789887242342 0.9909316833220855 1.0 12.67962202811327 -6.750870064886352 24.999878773403967 1.2414977049778233 1.0817385840617775 0.04880382053305299 0.2391854956104904 543.537689966047 1285642.6894164705 0.0787275562891159 0.07793684025303393 1.7747203741217308e-07 6.750870064886352 -0.15975912091604583 SES(ph)TENQSYAK ddPTM_A459_Selumetinib_30min_R2 3 SESTENQSYAK 11 0 Q96RT1-7;Q96RT1-6;Q96RT1-4;Q96RT1-5;Q96RT1-3;Q96RT1-9;Q96RT1-2;Q96RT1;Q96RT1-8 Q96RT1-7 ERBB2IP Protein LAP2 1 S(0.006)ES(0.993)T(0.001)ENQSYAK;SES(0.998)T(0.002)ENQSYAK;S(0.044)ES(0.879)T(0.076)ENQSYAK 165.35 5.1651e-05 0.0 62059.0 49054.1 50761.0 49089.0 49870.0 37336.5 55575.0 39902.9 34357.9 49313.1 True False 58610.00922186051 52816.39173620817 47495.09252439796 42402.99351675172 43604.88475654337 42479.263967998406 58159.347619773354 40019.01083271928 41230.44003993556 47889.302672179045 1.2238643277616483 1.1028849615488656 0.9917683046988676 0.8854376896447365 0.9105349696786318 0.8870303303179321 1.2144538419758746 0.8356565788118699 0.8609530258181874 1.0 15.547415807841809 -5.063667637381719 1.924629285408143 0.9428112671991719 1.2376307935727946 0.44331549344809185 0.10181860961063519 0.448092789106048 2.6098648353199234 0.029039664814257026 0.19307900479958182 8.63639232166628e-06 5.063667637381719 0.29481952637362274 SES(ph)VEGFLSPSR ddPTM_A459_Selumetinib_30min_R2 1 SESVEGFLSPSR 12 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.445)ES(0.555)VEGFLSPSR 127.79 0.0025426 4600700.0 8175.6 6658.5 7986.0 8012.6 7720.7 5461.5 8248.3 7633.1 5949.5 6684.4 True False 7721.232881519882 7169.185539548012 7472.189454499362 6921.270057494034 6750.756642066262 6213.772050439207 8631.86229369638 7655.311057272268 7139.56624291929 6491.4040038430685 1.1894549895444382 1.104412163424689 1.1510898797972895 1.0662208134629232 1.0399532424833904 0.9572308312285761 1.3297373401171932 1.1792997405091623 1.0998493143690478 1.0 12.66431483227269 -7.245959352434638 24.99782389305848 1.167163268414794 1.085761916859969 0.096987505667392 0.09665439700173951 1680.3800231571045 2713553.581814681 0.03732891277742313 0.028817421984913407 5.6759772693557334e-08 7.245959352434638 -0.08140135155482486 SES(ph)VVYADIR ddPTM_A459_Selumetinib_30min_R1 3 SESVVYADIR 10 0 O95297-4;O95297-2;O95297;O95297-5 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 SES(1)VVYADIR;S(0.001)ES(0.999)VVYADIR;S(0.008)ES(0.992)VVYADIR 173.04 0.00012617 6948400.0 4593.8 3785.6000000000004 4676.0 3711.81 4632.700000000001 4054.8 3938.8999999999996 4842.0 1696.0300000000002 3277.13 True False 4700.826602021225 3342.3801921223044 4041.0248834294393 3063.6120628031 4213.673102969617 4014.012393463834 3641.7856017734157 4713.574430967399 2878.0390368698836 3697.7815574493916 1.2712558946461134 0.9038879501653875 1.0928241218815549 0.828500011481554 1.1395137969902338 1.0855190689610579 0.9848568784266964 1.2747033208253298 0.7783150497551458 1.0 11.852444286231465 -7.2804218679338 0.007770557191307525 1.018595855083003e-07 2.0680427045304244 0.02947759154065921 0.1587113931668963 18599.919896962285 88.01444951643664 11568.628628974333 11845.580685652287 5.2429791672416605e-08 7.2804218679338 2.0680426026708387 SES(ph)VVYADIR ddPTM_A459_Selumetinib_30min_R2 3 SESVVYADIR 10 0 O95297-4;O95297-2;O95297;O95297-5 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 S(0.001)ES(0.999)VVYADIR;S(0.001)ES(0.999)VVYADIR;S(0.133)ES(0.867)VVYADIR 134.75 0.0032203 2476000.0 72680.0 35697.0 61708.0 69268.0 53332.0 46351.0 63081.0 59751.0 48530.0 46922.0 True False 68640.73656109217 38434.84511605396 57737.77446259038 59833.578906035094 46631.95736587069 52735.4295175149 66014.39149263014 59924.86551768948 58237.356041494735 45567.23994200295 1.5063615142908962 0.8434753819843609 1.2670895699646905 1.31308323660134 1.0233658528632168 1.1573101549410383 1.4487248202140817 1.315086575222915 1.2780531828484247 1.0 15.475709367126683 SESADQTVS(ph)PPTPFAR ddPTM_A459_Selumetinib_30min_R2 1 SESADQTVSPPTPFAR 16 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 SESADQT(0.168)VS(0.831)PPT(0.001)PFAR 114.58 0.0020736 4398800.0 21168.0 19236.0 25832.0 25104.0 28201.0 23825.0 20115.0 18732.0 19041.0 21683.0 True False 19991.567302217944 20711.339346511293 24169.997243755013 21684.791893184523 24658.13825986121 27106.67748818347 21050.387357116335 18786.507018750457 22849.732049991802 21056.95545080026 0.9494044544534653 0.9835866060933405 1.1478391213881038 1.0298161072644718 1.171021058456202 1.2873027894045954 0.9996880796134432 0.8921758448245416 1.0851394021980234 1.0 14.362009236921894 -7.49289031857919 24.99565005002012 0.9823808854636739 1.0969235087936329 0.1897275703614788 0.10121479166628795 1108.1970215216024 923695.6255749471 0.04502158354227063 0.030302954847483462 3.214472253690187e-08 7.49289031857919 0.11454262332995901 SESAPTLHPYS(ph)PLSPK ddPTM_A459_Selumetinib_30min_R2 2 SESAPTLHPYSPLSPK 16 0 Q8WUF5;K7EN03 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 SESAPT(0.002)LHPY(0.456)S(0.53)PLS(0.012)PK;SESAPTLHPY(0.167)S(0.804)PLS(0.029)PK 71.872 0.025672000000000004 5593900.0 44558.0 45670.0 50226.0 63566.0 53939.0 41931.0 46188.0 41630.0 32741.0 49146.0 True False 42081.644739806645 49172.74214780468 46994.51384193401 54908.201142533755 47162.70059922184 47706.61463828001 48335.83351978574 41751.13640778252 39290.114859974885 47727.02728335695 0.8817151860300564 1.0302913243656362 0.9846520203935187 1.1504634641613427 0.9881759515256485 0.9995723042846195 1.0127560057913159 0.874790213936951 0.8232256877577597 1.0 15.542518859306014 -7.758456301766377 24.812017898683138 0.8867559424064718 1.0113859306626876 0.3008588325137648 0.07410317957008346 74.00142357955446 615532.5668033927 0.036032602010037884 0.01963647338865298 1.7439888268776134e-08 7.758456301766377 0.12462998825621574 SESAPTLHPYSPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SESAPTLHPYSPLSPK 16 0 Q8WUF5;K7EN03 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 SESAPTLHPYS(0.021)PLS(0.979)PK;SESAPTLHPYS(0.034)PLS(0.966)PK 89.604 0.008615000000000001 50201000.0 7540.200000000001 8468.3 8605.2 9801.2 7749.3 8446.5 8323.8 8160.5 5166.3 7253.1 True False 7715.871989324839 7476.827499194137 7436.66110498012 8089.60441131032 7048.37718325004 8361.535878808387 7695.929064470174 7944.057030960236 8766.833768377255 8184.106036176834 0.9427873924430813 0.9135790110909782 0.9086711574981158 0.9884530302456027 0.8612275002417559 1.0216798074031843 0.9403506052403605 0.9706688789031458 1.0712023683007703 1.0 12.998609121934411 -7.662518860836759 0.9661957399485981 1.0283702970318358 0.9292044505812067 0.3869385928896939 0.04557941672365321 0.5703968804273881 0.9695571170061811 0.03760117296700305 0.016323287997341267 2.1751095698274395e-08 7.662518860836759 -0.09916584645062909 SESAPTLHPYSPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SESAPTLHPYSPLSPK 16 0 Q8WUF5;K7EN03 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 SESAPTLHPYSPLS(1)PK 183.73 8.5565e-07 5785300.0 24232.0 21876.0 27326.0 23604.0 25840.0 18345.0 18506.0 23845.0 14968.0 25939.0 True False 22885.282448381753 23553.818857573362 25567.874910299226 20389.094480828844 22593.748187469035 20871.857230670546 19366.565668943316 23914.38500224776 17962.018240863254 25190.073672384256 0.9085039903424644 0.9350436669581991 1.014998020364234 0.809409878907234 0.896930611689256 0.8285746799364169 0.7688173492789256 0.9493574855426077 0.7130593770575161 1.0 14.6205677210193 -5.770270749430936 24.999974765274818 0.8475886753857306 0.9510680758278245 0.23570278765488983 0.08264289412714997 245.3612359799018 694573.0728808151 0.021647071188210656 0.03265378438156979 1.6971852572326825e-06 5.770270749430936 0.10347940044209392 SESDLEDVGPTAEWNGDGSGS(ph)LRR ddPTM_A459_Selumetinib_30min_R1 2 SESDLEDVGPTAEWNGDGSGSLRR 24 1 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 SESDLEDVGPTAEWNGDGS(0.247)GS(0.753)LRR;SESDLEDVGPTAEWNGDGS(0.009)GS(0.991)LRR 90.964 2.4921e-05 11780600.0 2429.94 2439.69 2708.13 2940.97 2535.45 2634.5699999999997 2324.3 2653.82 1362.57 1913.86 True False 2486.5528741598355 2154.0499606188905 2340.380820693279 2427.384798344215 2306.1189951700544 2608.068617798165 2148.9761796953344 2583.4320727777567 2312.1817718246716 2159.5225735750764 1.1514363890363797 0.9974658227595528 1.0837491811066335 1.1240377053923054 1.0678837180906557 1.2077061150977104 0.995116330799783 1.1962977856262464 1.0706911796698049 1.0 11.0764966818343 -1.6935725872378615 17.854674145139402 1.093205815026439 1.131510352124602 0.0 0.07536062675233066 0.0 0.0 0.01590114885621047 0.0 0.020250111216390112 1.6935725872378615 0.03830453709816295 SESDLEDVGPTAEWNGDGSGS(ph)LRR ddPTM_A459_Selumetinib_30min_R2 1 SESDLEDVGPTAEWNGDGSGSLRR 24 1 Q9H0B6;Q9H0B6-2;A8MZ87 Q9H0B6 KLC2 Kinesin light chain 2 1 SESDLEDVGPT(0.002)AEWNGDGS(0.302)GS(0.696)LRR 59.302 0.0050332 5007200.0 11352.0 10851.0 9638.3 12371.0 10654.0 8692.2 8023.2 8212.5 7360.7 11036.0 True False 10721.101285656561 11683.236808535776 9018.182271387583 10686.048458834674 9315.54927203154 9889.471650064566 8396.294697669195 8236.39701534744 8833.04567514178 10717.36200502844 1.0003488993491463 1.0901224389970368 0.8414554129231031 0.9970782412519914 0.869201699789632 0.9227524129001671 0.783429233213338 0.7685097332238133 0.8241809571233514 1.0 13.387662220922406 -5.653669739232822 0.6949676012099428 0.8362417287282675 1.0658635202642774 0.3469219598425588 0.08328816638614239 1.2225243377484094 0.9329898854451573 0.04235799294040459 0.18780790123276547 2.2198838966166846e-06 5.653669739232822 0.22962179153600992 SESDLSQPES(ph)DEEGYALSGR ddPTM_A459_Selumetinib_30min_R2 1 SESDLSQPESDEEGYALSGR 20 0 Q15751;H0YNB1 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 SESDLSQPES(0.979)DEEGY(0.02)ALSGR 125.03 0.00022963 6734200.0 17810.0 12781.0 19997.0 23970.0 22081.0 20444.0 19903.0 20880.0 18493.0 19169.0 True False 16820.19149907887 13761.261602607656 18710.414791087387 20705.244649443615 19306.9873733554 23259.975427845675 20828.52893704632 20940.757343129917 22192.116737592467 18615.541162956695 0.9035564076186828 0.7392351091028913 1.0050964743544217 1.1122558548362402 1.0371434923296576 1.2494923045337516 1.1188785088071078 1.1249072567817797 1.192128477132475 1.0 14.184219936204396 -5.5044555582426735 3.098050211697237 1.1262857942030393 0.8220732416637202 0.7015631700030771 0.07665671484524521 0.12345464917117605 2.396698134464136 0.020447662093108828 0.04442108789126851 3.1300007510574064e-06 5.5044555582426735 -0.3042125525393191 SESELIDELS(ph)EDFDRSECK ddPTM_A459_Selumetinib_30min_R1 4 SESELIDELSEDFDRSECK 19 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 SESELIDELS(1)EDFDRSECK;SESELIDELS(1)EDFDRSECK;SESELIDELS(1)EDFDRSECK;SES(0.002)ELIDELS(0.996)EDFDRS(0.002)ECK 123.61 0.00022637 48683300.0 5404.4 6765.6 8474.2 8293.3 7014.0 6756.6 6381.6 6820.77 3693.0299999999997 5049.0599999999995 True False 5530.31200486819 5973.480406757891 7323.450185448628 6845.030839521677 6379.584938422274 6688.634738501958 5900.230774144367 6639.861022616585 6266.802181760691 5697.156033009193 0.9707145061194897 1.048502160051029 1.285457190046529 1.2014820727853903 1.1197841346558006 1.1740304635765915 1.0356449323063233 1.165469399845358 1.0999878089086872 1.0 12.476026203766201 -7.247821353361985 24.517768731654243 1.0890646455791284 1.1388698657622527 0.08179176446511982 0.08955132317360445 2035.911877181478 3665438.5135511905 0.036523776571376405 0.028135838283087633 5.6516940892281894e-08 7.247821353361985 0.04980522018312428 SESELIDELSEDFDR ddPTM_A459_Selumetinib_30min_R1 4 SESELIDELSEDFDR 15 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 0 ;;; 342.32 6.285999999999996e-145 10699800.0 3160.96 3027.7 2135.31 2538.52 2611.83 2033.926 2778.11 2619.94 1494.8600000000001 2464.1800000000003 False True 3234.6042178425273 2673.215476460456 1845.3466304182473 2095.2151359220775 2375.5904376560384 2013.4665510970494 2568.554926030808 2550.450680435507 2536.6682397453546 2780.4815061458194 1.1633252048945266 0.9614217791241306 0.6636788003586419 0.7535439927548276 0.8543809525095446 0.7241431193290071 0.9237806186998256 0.917269427902374 0.9123125739690936 1.0 11.441119026019607 -8.189193466179823 1.1955553517780009 0.9852434324625274 0.84884175482624 0.08370117357185569 0.1329284563066206 1.1707535925457548 3.220550021035428 0.1328142566321136 0.043766800888534366 6.468543958139291e-09 8.189193466179823 -0.1364016776362874 SESELIDELSEDFDR ddPTM_A459_Selumetinib_30min_R2 3 SESELIDELSEDFDR 15 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 0 ;; 345.57 2.4052999999999993e-145 5269900.0 13300.300000000001 8142.099999999999 9912.7 14030.4 11305.900000000001 9766.5 9043.0 12560.5 12169.0 10817.8 False True 12561.122571319407 8766.572889022123 9274.927674131717 12119.435316210001 9885.551765971597 11111.74672354014 9463.517418364552 12597.04897549729 14603.140030268902 10505.462005980125 1.1956754081038148 0.8344776159327255 0.8828671855509125 1.1536318259312288 0.9409916251512165 1.0577113807288907 0.9008187753168345 1.199095191465787 1.3900521482973538 1.0 13.358851989354779 -7.837317227063621 7.1366314994324584 1.2251469719824089 0.9913551883677033 0.2949231078582668 0.14065730488280545 0.24640249238629114 19.201965738196396 0.07387336048236551 0.035313591042791366 1.4543963398748942e-08 7.837317227063621 -0.23379178361470554 SESELIDELSEDFDRS(ph)ECK ddPTM_A459_Selumetinib_30min_R1 1 SESELIDELSEDFDRSECK 19 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 SESELIDELS(0.002)EDFDRS(0.998)ECK 74.214 0.0055078 1721400.0 563.23 654.47 567.42 725.9 557.46 653.41 784.78 827.39 468.3 747.67 True False 576.3521631451987 577.8443481451516 490.36748061495575 599.1351918306088 507.0378414275568 646.8372886488115 725.5834127699968 805.4449294585118 794.670896721265 843.640727422527 0.6831725216800016 0.6849412663025044 0.5812515501866724 0.710178127200039 0.6010115739393568 0.7667212684539483 0.860062096559496 0.9547250426366799 0.9419541647178727 1.0 9.720484933830237 -7.286600608232249 1.5569545252070376 0.967563952725426 0.6517641508412525 0.9134239657744053 0.04228676216496276 0.10290589146356702 0.4858058513303502 0.023596626191668142 0.013867646039790195 5.1689150152133724e-08 7.286600608232249 -0.31579980188417345 SESELIDELSEDFDRSECK ddPTM_A459_Selumetinib_30min_R1 2 SESELIDELSEDFDRSECK 19 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;D6RC54;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 0 ; 187.56 7.139699999999997e-15 4828500.0 1536.52 1582.3200000000002 2186.9 2265.13 1657.52 1435.0900000000001 1504.29 1399.3899999999999 1088.8799999999999 1382.3 False True 1572.3179264525345 1397.0612387993895 1889.9309917818318 1869.567567256187 1507.5976086589249 1420.654297557466 1390.8201941891728 1362.2736313406579 1847.74983135138 1559.7316697422127 1.008069501283129 0.8957061434998567 1.2117026463238985 1.1986469233936776 0.9665749807517184 0.9108325009469527 0.8917047856180563 0.8734025587656433 1.1846587891985099 1.0 10.607082139371705 -6.47981149983858 24.458659590310898 0.9569061096985411 1.0759379539560932 0.16139117938100445 0.11732620114618167 660.9973276862182 375391.9959468253 0.03826152570267355 0.04338072935907608 3.3127487605547217e-07 6.47981149983858 0.11903184425755209 SESETST(ph)MAAK ddPTM_A459_Selumetinib_30min_R2 1 SESETSTMAAK 11 0 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 S(0.001)ES(0.039)ET(0.115)S(0.255)T(0.591)MAAK 113.38 0.016678 9419700.0 28138.0 27660.0 32371.0 33566.0 36084.0 24689.0 28589.0 27209.0 22273.0 26988.0 True False 26574.20260533862 29781.43305908207 30288.285102879905 28994.25289542032 31550.805324947087 28089.685645572376 29918.445148028797 27288.173685307564 26728.22235961701 26208.786316754926 1.013942510888041 1.1363148487361736 1.1556538611449172 1.1062798767177053 1.2038255012509709 1.07176598359364 1.1415425646361326 1.041184179820742 1.0198191566974628 1.0 14.677762926068105 -7.883803715529552 4.119316839202705 1.0153060331165993 1.1215681016622125 0.47006208096058133 0.04820536495583722 0.19169715856188746 5.793796532219965 0.028174632061481276 0.012664553282672356 1.306761360766691e-08 7.883803715529552 0.10626206854561326 SESGGLGVSMVEYVLSS(ph)SPGDSCLRK ddPTM_A459_Selumetinib_30min_R1 2 SESGGLGVSMVEYVLSSSPGDSCLRK 26 1 Q5T1Z4;Q5T1Z8;Q14671-2;Q14671;Q14671-3;H0YEH2 Q5T1Z4 PUM1 Pumilio homolog 1 1 SESGGLGVSMVEYVLS(0.002)S(0.842)S(0.155)PGDSCLRK;SESGGLGVSMVEYVLS(0.001)S(0.618)S(0.379)PGDS(0.002)CLRK 159.36 2.7456999999999998e-14 29910000.0 2940.2 2998.2 5445.9 5384.700000000001 3619.6 3593.3999999999996 3150.2 3320.4 2105.4 2723.4 True False 3008.700939366712 2647.169350174635 4706.376692187422 4444.363228337618 3292.207819092285 3557.253658546152 2912.57787775943 3232.3322058207673 3572.710027668056 3072.9749181624416 0.97908411864482 0.8614353910046141 1.531537619904074 1.4462738377946902 1.0713422357058933 1.157592806085543 0.9478039864708936 1.051857659727863 1.1626225800126095 1.0 11.585420276262557 -6.466263389049274 24.999745400872733 1.0660115752453807 1.210348916255897 0.11159766912397806 0.19243141903040592 724.578796727921 319952.9777927086 0.06565854917975916 0.07444952875340827 3.4177210317192326e-07 6.466263389049274 0.1443373410105162 SESLIDASEDS(ph)QLEAAIR ddPTM_A459_Selumetinib_30min_R1 4 SESLIDASEDSQLEAAIR 18 0 C9JAT7;O94888 C9JAT7 UBXN7 UBX domain-containing protein 7 1 SESLIDASEDS(1)QLEAAIR;SES(0.094)LIDASEDS(0.906)QLEAAIR;SES(0.001)LIDASEDS(0.998)QLEAAIR;SESLIDASEDS(1)QLEAAIR 248.7 7.433999999999998e-33 58178200.0 7965.110000000001 11478.849999999999 11151.18 12018.83 10202.93 9991.880000000001 11923.36 10170.1 6269.34 7667.8 True False 8150.6815655939035 10134.900905627406 9636.911005047205 9919.966961881075 9280.0767829736 9891.370759101166 11023.971355647798 9900.355910859465 10638.61208552316 8652.03682069691 0.9420534995986501 1.171389016905623 1.113831483240378 1.146547011699152 1.072588683484833 1.143241870566199 1.274147531281522 1.1442803718976782 1.2296078144367206 1.0 13.078824089689649 -6.994931660686375 17.631605189200794 1.1789839622353357 1.099340557971575 0.1188868318187376 0.0882852056605306 6.789877396491971 23610.260854394885 0.029562670636628402 0.025820970768917227 1.0117386459785265e-07 6.994931660686375 -0.07964340426376082 SESLIDASEDS(ph)QLEAAIR ddPTM_A459_Selumetinib_30min_R2 5 SESLIDASEDSQLEAAIR 18 0 C9JAT7;O94888 C9JAT7 UBXN7 UBX domain-containing protein 7 1 SESLIDASEDS(1)QLEAAIR;SESLIDAS(0.001)EDS(0.999)QLEAAIR;SESLIDASEDS(1)QLEAAIR;SESLIDAS(0.002)EDS(0.998)QLEAAIR;SESLIDASEDS(1)QLEAAIR 235.37 1.0298e-19 7883900.0 43796.5 45790.100000000006 55734.6 56711.2 52847.46 51807.2 39748.799999999996 50926.5 37175.2 44361.21 True False 41362.465861280594 49302.05343162235 52148.696515244206 48987.036727723316 46208.28961251325 58943.1715410627 41597.197960752994 51074.68768366406 44611.278761874644 43080.386603034385 0.9601229033159886 1.1444199395404158 1.2104974125643313 1.1371076397042568 1.0726061963719367 1.3682136161914344 0.9655716032460832 1.1855670691698619 1.0355357107852052 1.0 15.394743576223071 -8.425680168666064 4.976777302437195 1.0008811218542097 1.1340905653683095 0.14148944869936175 0.1122354238964719 0.3803902877168353 13.808682449352945 0.10312796004230104 0.026857880813671093 3.752492486432668e-09 8.425680168666064 0.1332094435140998 SESLS(ph)NCSIGK ddPTM_A459_Selumetinib_30min_R2 1 SESLSNCSIGK 11 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 SES(0.154)LS(0.599)NCS(0.247)IGK 120.59 0.0046868000000000005 20935000.0 53403.0 43654.0 64249.0 53466.0 57347.0 43685.0 51688.0 37518.0 31274.0 48690.0 True False 50435.07504914703 47002.1214302664 60115.28928902199 46183.83856600557 50142.557171315246 49702.21221705333 54091.59441782893 37627.17116856075 37529.67386857011 47284.19318818725 1.066637107424452 0.9940345443391996 1.2713612147249296 0.9767289119684806 1.0604507297343944 1.0511379991034755 1.1439677991871147 0.7957663783921968 0.7937044356283094 1.0 15.529070359725623 -7.76367709804053 24.999999681911 0.8460515143980588 1.0787180197785333 0.5246652225535648 0.09441997085275457 42.70955953588386 477131.69741951005 0.04695486794635573 0.02427552057416228 1.7231492762263794e-08 7.76367709804053 0.2326665053804745 SESPCES(ph)PYPNEKDK ddPTM_A459_Selumetinib_30min_R2 1 SESPCESPYPNEKDK 15 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H0Y594;B7ZBA0;B7ZB98 A0A0C4DG98 THOC2 THO complex subunit 2 1 S(0.125)ES(0.109)PCES(0.641)PY(0.125)PNEKDK 61.097 0.044588 8248600.0 25700.0 22188.0 26336.0 34219.0 30441.0 23601.0 25574.0 28833.0 16910.0 20677.0 True False 24271.696885251356 23889.748254335245 24641.57043246874 29558.313168932487 26616.72943400714 26851.823521453014 26763.241673919616 28916.89925643991 20292.47250487691 20080.001284702153 1.2087497675482035 1.1897284226040128 1.2271697637410908 1.4720274540744844 1.3255342495562965 1.337242121688007 1.332830675379939 1.4400845321892535 1.010581235387501 1.0 14.293471741140593 -8.277059469901637 24.604063658459634 1.0052904684189705 1.3161544516065007 0.671298820422678 0.08715468797906407 470.9798383116424 741857.4964837411 0.08935064320089132 0.023414005492431555 5.283728943383278e-09 8.277059469901637 0.31086398318753017 SESQESLVT(ph)SPSKPK ddPTM_A459_Selumetinib_30min_R1 1 SESQESLVTSPSKPK 15 1 E7EWD6;Q76L83;Q76L83-2;A0A5F9ZHN2 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 SESQES(0.002)LVT(0.719)S(0.278)PSKPK 175.27 0.00020642 11605000.0 4241.3 4748.3 3745.7 3953.0 3350.7 3949.3 3856.4 3995.3 2627.1 3942.5 True False 4340.1140378668215 4192.366828575217 3237.054513657324 3262.682757000134 3047.6297766141333 3909.5736276774956 3565.508643194546 3889.331665436605 4457.996824207632 4448.558278202033 0.9756226099438577 0.9424102296507713 0.7276637308583579 0.7334247531357075 0.6850825786744306 0.8788406002984009 0.8014975684741646 0.8742903705441734 1.0021217089707126 1.0 12.119122137168741 -8.139471748048429 2.708314072531656 1.0065251725215996 0.8154931937271207 0.39303447185920415 0.08815202732157726 0.3168987032676539 4.166745279666304 0.08304522483288682 0.026005844062635484 7.2531766030001184e-09 8.139471748048429 -0.19103197879447886 SESQESLVT(ph)SPSKPK ddPTM_A459_Selumetinib_30min_R2 1 SESQESLVTSPSKPK 15 1 E7EWD6;Q76L83;Q76L83-2;A0A5F9ZHN2 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 SESQESLVT(0.499)S(0.499)PS(0.002)KPK 92.633 0.018415 53173000.0 166800.0 111470.0 148090.0 147450.0 125360.0 108870.0 152520.0 161380.0 111880.0 120420.0 True False 157529.92375330473 120019.39056745745 138562.05062820078 127367.05563456222 109611.15606738077 123865.85427653886 159612.4822126466 161849.58908210282 134259.1261883874 116943.16171126513 1.347064004838941 1.0263053333874073 1.1848666360698636 1.089136412687677 0.9373028269751487 1.0591970703029732 1.3648723010134858 1.3840021657847126 1.1480716291891928 1.0 16.835447976540266 -7.244638247868054 24.360215061183062 1.2562367141370552 1.0986012696428997 0.11984465788842391 0.14406396796855134 911.3055462867399 1321317.2401058676 0.054479326275498056 0.04206911458126253 5.693269628617881e-08 7.244638247868054 -0.15763544449415545 SESQESLVTS(ph)PSKPK ddPTM_A459_Selumetinib_30min_R1 1 SESQESLVTSPSKPK 15 1 E7EWD6;Q76L83;Q76L83-2;A0A5F9ZHN2 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 SESQESLVT(0.117)S(0.879)PS(0.004)KPK 198.15 0.00012395 10345000.0 3087.4 3197.4 2630.2 2694.5 2381.9 2016.5 2303.9 2289.3 1211.3 2048.8 True False 3159.3304129653725 2823.0469215690664 2273.033286654431 2223.9561570293085 2166.4575655586004 1996.2158408355078 2130.1149681194697 2228.5803273055903 2055.4876301483414 2311.7834370019855 1.3666204032772724 1.2211554405935654 0.983237984264734 0.9620088635609506 0.9371369008371089 0.863496038982043 0.9214163117639986 0.9640091245725437 0.8891350276364905 1.0 11.174790540200975 -5.090988291872564 1.6099407209811907 0.9261934394562734 1.4159098944482131 0.9405779281904944 0.03666399023349855 0.12161198187029817 0.45852058418317054 0.010428273158977527 0.07772993108053029 8.10982920815019e-06 5.090988291872564 0.4897164549919397 SESS(ph)DFEVVPK ddPTM_A459_Selumetinib_30min_R1 1 SESSDFEVVPK 11 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.03)ES(0.235)S(0.735)DFEVVPK 125.72 0.0032958 7802400.0 5570.9 6255.6 6371.9 6492.1 6044.0 5430.3 6312.0 6448.1 3666.3 5488.9 True False 5700.691130915586 5523.19144385046 5506.630978341328 5358.37660681016 5497.321267154865 5375.676112317908 5835.8807581796445 6277.075441619342 6221.44332404265 6193.453781413609 0.9204381484242619 0.8917789070171818 0.8891050410138818 0.8651677716382589 0.8876018876014189 0.8679609636306916 0.9422659737435949 1.013501620122956 1.0045192139340793 1.0 12.596528437840309 -7.552572452737705 3.1820386796821882 1.0066919531220218 0.8866534480234308 0.9266798088815623 0.014983351509997045 0.06252934029557272 1.3076920494613529 0.008101020005388643 0.004497764133948411 2.8017381726364026e-08 7.552572452737705 -0.12003850509859093 SESS(ph)DFEVVPK ddPTM_A459_Selumetinib_30min_R2 2 SESSDFEVVPK 11 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.024)ES(0.116)S(0.861)DFEVVPK;S(0.001)ES(0.074)S(0.925)DFEVVPK 172.92 0.00021965 6915500.0 76500.0 62072.0 76815.0 82463.0 79527.0 53679.0 68549.0 78084.0 53268.0 58938.0 True False 72248.43625376385 66832.72280706231 71872.80652984828 71231.3971433903 69536.10727959941 61072.79500055408 71736.66432726664 78311.21151249796 63923.088432275785 57236.30680068561 1.262283335389809 1.1676630890912365 1.2557205478007423 1.2445142100352473 1.2148950756334695 1.067028926468444 1.2533419491421018 1.3682086753990197 1.1168276222796065 1.0 15.80464296404881 -8.524280317076931 24.81883876145842 0.9999999940023272 1.224661487960919 0.5044300951386472 0.0723842439881573 103.15791090456862 1826718.1891787166 0.07182693347720832 0.01854563451030768 2.9903338908316227e-09 8.524280317076931 0.2246614939585918 SESSTSAFST(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 SESSTSAFSTPTR 13 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 SESSTSAFS(0.007)T(0.993)PTR;SESSTSAFS(0.002)T(0.998)PTR 225.33 3.5397e-09 33489000.0 9820.0 11264.5 11349.6 12002.6 10956.900000000001 9886.599999999999 10224.5 9260.1 5146.1 8079.5 True False 10048.786893606257 9945.647103276018 9808.386658890247 9906.571226706239 9965.850329597815 9787.149780314565 9453.25773320782 9014.492066956047 8732.555843726883 9116.582525994501 1.1022537080044765 1.0909402810666793 1.0758841518653701 1.086654039324408 1.093156377533112 1.073554673849334 1.0369299796555718 0.9888016744490209 0.9578760263319477 1.0 13.154277396684446 -7.529777094216391 1.7961672831169604 0.9760172314952222 1.0885740658775813 0.941038200350103 0.011830265086471016 0.07655898615816874 0.4836721481310575 0.007423475645433561 0.0036654727941793494 2.952724351733148e-08 7.529777094216391 0.11255683438235908 SESSTSAFST(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 SESSTSAFSTPTR 13 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 SESSTSAFS(0.016)T(0.919)PT(0.065)R 108.23 0.014842 14515000.0 26867.0 22675.0 27305.0 30657.0 31858.0 24503.0 24917.0 25589.0 24939.0 23544.0 True False 25373.83969712252 24414.09958838345 25548.226027436176 26481.4637137252 27855.713225866406 27878.06583391225 26075.689872098836 25663.459753513 29927.496853880875 22864.22354534157 1.1097617046476203 1.0677860781044393 1.1173887438937962 1.158205248527699 1.2183100454133644 1.2192876691669774 1.1404581406575505 1.122428658144473 1.3089225092001167 1.0 14.480804306509528 -5.701584171583887 2.8951353754202507 1.1761937360627197 1.0894781517091614 0.14707831994128717 0.0758445615467345 0.4209166499669697 7.133075228214938 0.02072408046820287 0.03835353266341198 1.98799747482418e-06 5.701584171583887 -0.0867155843535583 SESVEGFLS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 SESVEGFLSPSR 12 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 SESVEGFLS(0.881)PS(0.119)R 98.368 0.015348 36731000.0 481.69 723.68 762.95 947.61 819.79 712.95 844.13 472.96 401.99 536.91 True False 492.9124397944194 638.9512091702957 659.3455805843652 782.1277023427514 745.64013924568 705.7783703068069 780.4565944870378 460.41556440940496 682.147669812046 605.8276284462787 0.8136182911607308 1.054674925950417 1.088338579531838 1.291006988817292 1.2307793574188224 1.1649821453618159 1.2882486004948588 0.7599778266801709 1.1259764952640072 1.0 9.242763562747125 -7.751978507578773 24.99998779980081 0.9572328376902817 1.1394126171393832 0.20350570163039594 0.15468639251849975 301.4214737666701 796499.798602404 0.07598933498607124 0.04312881718744239 1.770196559865016e-08 7.751978507578773 0.18217977944910158 SESVEGFLS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 SESVEGFLSPSR 12 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 SESVEGFLS(0.999)PS(0.001)R;SESVEGFLS(0.996)PS(0.004)R 129.54 0.0022951 20296800.0 17868.6 18499.8 21038.2 21041.1 26215.0 16416.3 17706.7 16703.1 14947.6 18755.4 True False 16875.53474567325 19918.675173767413 19684.625116660223 18175.265882077943 22921.63733492649 18677.496312665946 18530.09663516043 16751.703255652945 17937.53767083963 18213.882869618552 0.92652043863872 1.0935985103424881 1.0807484190806413 0.9978798047721597 1.2584706676224788 1.0254538500311057 1.0173611397309101 0.9197216966622433 0.9848277711700959 1.0 14.152750891078913 -7.346541524008005 2.836162343505843 0.9663162559032634 1.072775397650483 0.20799984405039462 0.08245266078225699 0.4020644768888016 6.303603161873971 0.03887080173484426 0.02469863407693228 4.502549292027023e-08 7.346541524008005 0.1064591417472196 SESVVSGLDS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 SESVVSGLDSPAK 13 0 H7BYJ3;O14578;O14578-4;O14578-2 H7BYJ3 CIT Citron Rho-interacting kinase 1 SESVVS(0.007)GLDS(0.993)PAK 88.78 0.02334 62422000.0 1925.2 2008.4 1800.1 1766.2 1945.6 2002.2 1755.7 1541.1 1079.9 1801.2 True False 1970.0534142129077 1773.255594320172 1555.6563072415167 1457.7663256801493 1769.6208235235795 1982.059685852147 1623.2661354778209 1500.2250218017039 1832.5114272246294 2032.4015651737477 0.9693229172673314 0.8724927320987269 0.7654276270489515 0.7172629418613573 0.8707043203700232 0.975230348084633 0.7986936062702007 0.7381538410070312 0.9016483054459614 1.0 10.98896976494535 SESVVY(ph)ADIR ddPTM_A459_Selumetinib_30min_R2 1 SESVVYADIR 10 0 O95297-4;O95297-2;O95297;O95297-5 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 SESVVY(1)ADIR 128.38 0.043723000000000005 4077700.0 40996.0 14190.0 33606.0 41108.0 29343.0 27994.0 37035.0 34974.0 22281.0 23815.0 True False 38717.60643999085 15278.32737195859 31443.826547446242 35509.019484744604 25656.670010251677 31849.919395769488 38757.200883460275 35075.768549742614 26737.82258315568 23127.399071199005 1.6741011957633676 0.6606158922118046 1.359591990895502 1.5353658824940963 1.1093625327805419 1.3771509410858398 1.6758132103028118 1.5166326503797456 1.1561102266987215 1.0 14.497315407820517 -5.472750324426519 24.99599677992918 1.3725094666914261 1.128044900655174 0.03968898361933282 0.3017969527037673 815.6400377589556 406708.1717019361 0.07508909159835328 0.15630706483751305 3.3670508524628137e-06 5.472750324426519 -0.2444645660362521 SET(ph)PPHWR ddPTM_A459_Selumetinib_30min_R1 3 SETPPHWR 8 0 Q13427;E9PG73;C9JM79 Q13427 PPIG Peptidyl-prolyl cis-trans isomerase G 1 SET(1)PPHWR;SET(1)PPHWR;S(0.002)ET(0.998)PPHWR 133.23 0.0042221 23179900.0 13601.099999999999 15843.800000000001 16050.4 16463.4 14562.7 12948.5 15627.3 13599.5 7729.7 12655.5 True False 13917.979166866398 13988.800530417211 13870.843838536333 13588.37624629293 13245.506356253503 12818.24984629734 14448.520179388588 13238.79708259833 13116.736345048812 14279.956700009097 0.9746513563908448 0.9796108506693371 0.9713505530816838 0.9515698493878677 0.927559280081365 0.897639265691133 1.0118042010154964 0.9270894415660165 0.9185417449508412 1.0 13.801703984352256 -5.780599392474522 3.3782518680088574 0.9439210525936523 0.9766259284732277 0.12229249745502058 0.03334026604161029 0.4542296119231439 10.790651326488874 0.009531092330678502 0.016093240545767145 1.6572980048351433e-06 5.780599392474522 0.03270487587957538 SET(ph)PPVPPPPPYLASYPGFPENGAPGPPISR ddPTM_A459_Selumetinib_30min_R1 1 SETPPVPPPPPYLASYPGFPENGAPGPPISR 31 0 P48634;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 S(0.257)ET(0.728)PPVPPPPPY(0.012)LAS(0.003)Y(0.001)PGFPENGAPGPPISR 52.675 0.010507 15537000.0 1483.1 2413.8 2392.6 2616.7 1965.7 2120.9 2152.8 1770.5 1122.0 1771.1 True False 1517.6533443897583 2131.191173854825 2067.6980616110513 2159.7424665424355 1787.902782072522 2099.5656716231238 1990.4125627707767 1723.540588605489 1903.9520523622882 1998.4379369749204 0.7594198029922629 1.0664285011927146 1.0346571306292212 1.0807153059812733 0.8946501409890717 1.050603390166463 0.9959841764131581 0.8624438901587559 0.9527201306257939 1.0 10.964657054113554 SET(ph)SPVAPR ddPTM_A459_Selumetinib_30min_R1 2 SETSPVAPR 9 0 A0A2R8Y661;A0A2R8YGD3;Q9Y4G8;H0Y8T6;H0Y8H7 A0A2R8Y661 RAPGEF2 Rap guanine nucleotide exchange factor 2 1 S(0.069)ET(0.581)S(0.35)PVAPR;S(0.008)ET(0.655)S(0.337)PVAPR 133.99 0.0069912 69142000.0 7958.099999999999 9476.0 9225.5 10073.3 9808.7 8065.0 9289.0 8224.599999999999 4643.6 7867.4 True False 8143.508246232981 8366.545514727113 7972.727772044126 8314.187254259907 8921.50481686664 7983.8734224341015 8588.3232513832 8006.456890734086 7879.850044874789 8877.257424965548 0.9173450601230689 0.9424696293246878 0.8981070831203329 0.9365716072261105 1.0049843538136738 0.8993626116981829 0.9674523155350011 0.9019065807664306 0.887644648302555 1.0 13.115898318158896 -4.744950273104952 23.154607646345138 0.9351212807194887 0.9173449307792283 0.019008105969178235 0.04024608696692868 2306.647498435798 3238615.358369553 0.009741118165502426 0.23042155088331248 1.7990768983735323e-05 4.744950273104952 -0.01777634994026045 SETAPAAPAAPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 4 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 SETAPAAPAAPAPAEKT(1)PVK;SETAPAAPAAPAPAEKT(1)PVK;SETAPAAPAAPAPAEKT(1)PVK;SETAPAAPAAPAPAEKT(1)PVK 153.93 6.912e-06 300167000.0 28378.799999999996 42243.600000000006 31342.2 37073.5 28276.2 28104.2 25680.0 20579.2 17033.1 26619.199999999997 True False 29039.970824467717 37297.699673483155 27086.101390381154 30599.309180785334 25718.622702568562 27821.49726457191 23742.936924913396 20033.372765337524 28903.926651597205 30036.03361296527 0.9668377389194425 1.241765146293595 0.9017868916849674 1.0187533272561302 0.8562589532949162 0.926270679513508 0.7904817670288059 0.6669779713087675 0.9623083734704777 1.0 14.874406690913123 -5.942218759408378 1.056175879995501 0.839333542662204 1.0934874754550234 0.3113691914011981 0.11944194820699788 0.5725497800876336 1.2849146386066863 0.04632136329508495 0.10383389112603898 1.142302798048093e-06 5.942218759408378 0.2541539327928195 SETAPAAPAAPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 4 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 SETAPAAPAAPAPAEKT(1)PVK;SETAPAAPAAPAPAEKT(1)PVK;SETAPAAPAAPAPAEKT(1)PVK;SETAPAAPAAPAPAEKT(1)PVK 131.84 0.00020929 256222000.0 763580.0 719240.0 682290.0 675540.0 635000.0 494445.0 639730.0 493805.0 378978.0 789040.0 True False 721143.2804529277 774403.3952788922 638392.2042211852 583530.2866285015 555225.623027973 562550.3106251782 669478.7126009457 495241.8907961817 454784.18953005597 766258.3650278769 0.9411228814796587 1.010629613486463 0.8331291811711056 0.7615320279175971 0.7245932290837355 0.7341522602558632 0.8736984066419813 0.6463118882599924 0.5935128545233052 1.0 19.547471392823738 -5.470786037052677 2.863093820150422 0.7493448166290011 0.9763890337134254 0.373086693780196 0.10832034892021629 0.2570192428656718 4.128454712208393 0.02946993348015958 0.0681628128351338 3.3823143093108525e-06 5.470786037052677 0.22704421708442435 SETAPAAPAAPAPAEKT(ph)PVKK ddPTM_A459_Selumetinib_30min_R1 3 SETAPAAPAAPAPAEKTPVKK 21 2 P10412 P10412 HIST1H1E Histone H1.4 1 SETAPAAPAAPAPAEKT(1)PVKK;SETAPAAPAAPAPAEKT(1)PVKK;SETAPAAPAAPAPAEKT(1)PVKK 130.07 9.6397e-05 84054000.0 14196.3 21341.6 16844.4 19641.0 13105.400000000001 14354.6 12387.9 9334.2 7296.7 11849.8 True False 14527.046168808802 18842.91555055933 14557.022999666142 16211.068057232387 11920.018883946295 14210.205756933989 11453.470729444487 9086.626694245331 12381.966970117563 13370.837256826499 1.0864724392178209 1.4092547226942767 1.0887143953707188 1.2124198167886462 0.8914938275731772 1.06277606136287 0.8566008627168731 0.6795854679635819 0.9260427550111668 1.0 13.706802186674981 -6.370413763695713 1.0365661931189278 0.8522041219905759 1.2400796753347174 0.54271164575133 0.1296918580185687 0.3609779965944828 0.8224041540330249 0.058825489045608456 0.08025651237986053 4.2617329889160987e-07 6.370413763695713 0.3878755533441415 SETAPAAPAAPAPAEKT(ph)PVKK ddPTM_A459_Selumetinib_30min_R2 2 SETAPAAPAAPAPAEKTPVKK 21 2 P10412 P10412 HIST1H1E Histone H1.4 1 SETAPAAPAAPAPAEKT(1)PVKK;SETAPAAPAAPAPAEKT(1)PVKK 109.36 0.00015169 53828000.0 602770.0 632860.0 545140.0 476190.0 436650.0 322280.0 415670.0 292190.0 271130.0 571610.0 True False 569270.4564794931 681398.3270343705 510066.2859035552 411332.1005264319 381794.1232994722 366671.1446334423 434999.4786344795 293040.22452534176 325363.57600516133 555106.1340788604 1.02551642205168 1.2275099934989524 0.9188626365117655 0.7409972170619116 0.6877858122267356 0.6605424118432668 0.7836329882326285 0.5278994529786828 0.5861285906073936 1.0 19.082404109810234 -5.598316673525235 2.506710900137238 0.6883587356530203 1.126742625936279 0.6194455994284209 0.12951712120136605 0.16423086545840568 2.0714768655581732 0.03573057745026157 0.07579491245848133 2.521641402398583e-06 5.598316673525235 0.43838389028325864 SETAPAETATPAPVEKS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 5 SETAPAETATPAPVEKSPAK 20 1 P16401 P16401 HIST1H1B Histone H1.5 1 SETAPAETAT(0.007)PAPVEKS(0.993)PAK;SETAPAETAT(0.001)PAPVEKS(0.999)PAK;SETAPAETATPAPVEKS(1)PAK;SETAPAETAT(0.002)PAPVEKS(0.998)PAK;SETAPAETAT(0.008)PAPVEKS(0.992)PAK 162.82 2.5396000000000003e-07 559260900.0 12589.1 19659.199999999997 17258.4 18129.9 13460.5 13525.82 12186.940000000002 10626.47 8234.14 12444.17 True False 12882.401535875608 17357.491724685864 14914.804073605363 14963.853305372297 12243.000151644286 13389.76253126196 11267.669304038323 10344.621495960782 13972.734182208913 14041.500435980564 0.9174519200857745 1.2361564779934953 1.062194467151602 1.0656876288682264 0.8719153773817703 0.9535848816378225 0.8024547914527387 0.7367176708162373 0.9951026420513123 1.0 13.777409485839273 -6.230714256035997 4.318664690950361 0.87764722185661 1.084780108240811 0.39553201892198764 0.1056977084190709 0.1930609674683577 8.585394461326622 0.03168686431485724 0.04005477771917916 5.878760182163882e-07 6.230714256035997 0.20713288638420102 SETAPAETATPAPVEKS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 5 SETAPAETATPAPVEKSPAK 20 1 P16401 P16401 HIST1H1B Histone H1.5 1 SETAPAETATPAPVEKS(1)PAK;SETAPAETATPAPVEKS(1)PAK;SETAPAET(0.017)AT(0.01)PAPVEKS(0.972)PAK;SETAPAETATPAPVEKS(1)PAK;SETAPAETATPAPVEKS(1)PAK 125.08 0.00012599 415205300.0 471997.0 503881.0 438947.0 352543.0 289387.0 237059.7 337489.0 242009.8 155826.0 438242.0 True False 445765.29629369645 542527.0524672198 410705.62790935795 304526.03522940347 253031.61790739544 269712.5218613021 353182.907221767 242714.00845112067 186995.55414222073 425588.81477053993 1.0474083923799427 1.2747681180477644 0.9650291869883696 0.7155405044974958 0.5945448026960477 0.6337396860552363 0.8298688662957197 0.5703016621383298 0.4393808005575548 1.0 18.699100709187746 -5.637778803023744 2.7683523941876045 0.6616599791539235 1.159583420694905 0.6173290603074069 0.15328897246199436 0.1583483991829778 2.4335754446502564 0.04251972071554466 0.08387850915936651 2.3026142975015675e-06 5.637778803023744 0.49792344154098145 SETAPAETATPAPVEKS(ph)PAKK ddPTM_A459_Selumetinib_30min_R1 1 SETAPAETATPAPVEKSPAKK 21 2 P16401 P16401 HIST1H1B Histone H1.5 1 SETAPAET(0.003)AT(0.042)PAPVEKS(0.955)PAKK 78.428 0.020427 0.0 786.9 805.13 971.35 1254.4 524.7 720.19 637.71 738.58 404.46 526.15 True False 805.2332389591401 710.8650053052178 839.4460052436244 1035.3425880042919 477.2409776433093 712.9455424802003 589.6070212767339 718.990459154048 686.339079410384 593.6864776350029 1.3563274039301862 1.1973744258703767 1.4139550703388497 1.7439214585595095 0.8038602791568312 1.2008788634032483 0.9931286015229455 1.2110608650178516 1.1560631836259267 1.0 9.21355744306811 -6.267973050588802 24.99996253307768 1.07500219793451 1.410433184370947 0.52850224486036 0.16921074415935314 469.34229442767344 1795853.3951563141 0.05310970200735589 0.06165314045705827 5.395441019751228e-07 6.267973050588802 0.3354309864364371 SETAPAETATPAPVEKS(ph)PAKK ddPTM_A459_Selumetinib_30min_R2 2 SETAPAETATPAPVEKSPAKK 21 2 P16401 P16401 HIST1H1B Histone H1.5 1 SETAPAETATPAPVEKS(1)PAKK;SETAPAETATPAPVEKS(1)PAKK 137.27 1.1889e-05 10296500.0 132755.0 153192.0 121256.0 103708.0 87080.0 69729.0 91862.0 71022.0 51490.0 134526.0 True False 125377.00856037153 164941.33381008354 113454.52097355037 89582.79149372126 76140.23189492269 79333.53681316032 96133.76502109977 71228.66226167486 61789.438750804984 130641.88483947596 0.9596999363138893 1.2625455765029145 0.8684391006219463 0.685712638054745 0.5828163914542318 0.6072595853208952 0.7358571497894609 0.5452207180660008 0.47296805941469483 1.0 16.995257985122578 -5.571993483883928 2.9191527539692617 0.63847368208695 1.1104856965865397 0.5783810862653354 0.1522353551618502 0.15794215641723802 2.7165617067880414 0.040549551902373596 0.0835301345191364 2.6792085231256593e-06 5.571993483883928 0.47201201449958974 SETAPLAPTIPAPAEKT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 SETAPLAPTIPAPAEKTPVK 20 1 P16402 P16402 HIST1H1D Histone H1.3 1 SETAPLAPT(0.005)IPAPAEKT(0.995)PVK;SETAPLAPTIPAPAEKT(1)PVK 101.08 0.00099894 3569800.0 44724.0 44807.0 39911.0 39782.0 33723.0 26659.0 32335.0 28653.0 21873.2 36725.0 True False 42238.41912435727 48243.55282278707 37343.16971181121 34363.6229722222 29486.415252554867 30331.035263692913 33838.64157058697 28736.375486240508 26248.45118827165 35664.65382699068 1.1843215787052341 1.3526993155973601 1.0470638490692499 0.9635204406839392 0.8267685814530413 0.850450852848 0.9488005052492112 0.8057382422843842 0.7359794186031623 1.0 15.122207349900137 -5.605965235362733 1.9179772089569858 0.8584407748543089 1.2722483133875282 0.7750379120228957 0.08434759050659398 0.14584960152210757 1.0695643125836636 0.02460426809008238 0.059035233902437124 2.4776203795784834e-06 5.605965235362733 0.4138075385332193 SETILS(ph)PPPEKR ddPTM_A459_Selumetinib_30min_R2 2 SETILSPPPEKR 12 1 Q9P0M6 Q9P0M6 H2AFY2 Core histone macro-H2A.2 1 S(0.001)ET(0.009)ILS(0.99)PPPEKR;S(0.003)ET(0.003)ILS(0.994)PPPEKR 76.01 0.024935 10114300.0 80498.0 48230.0 47609.0 77549.0 45959.0 62022.0 91951.0 99384.0 71464.0 46954.0 True False 76024.24341902582 51929.08591610734 44545.888772759856 66986.69242051317 40185.219541326966 70564.96752034065 96226.90369744995 99673.19098609315 85758.79687099476 45598.31601885697 1.6672598915185015 1.1388378003835122 0.9769196027839737 1.469060664275653 0.8812873599259359 1.547534507440118 2.110317048937855 2.1858963156638014 1.8807448247766347 1.0 15.476692925077524 -7.003663721494637 6.979309699362885 1.8857590531599384 1.219551418921315 0.3340104336467449 0.369851319018441 0.12950455829002672 37.14826250135427 0.1298523393441586 0.10831289102002399 9.915994529569092e-08 7.003663721494637 -0.6662076342386234 SETIQDTDTQSLVGS(ph)PSTR ddPTM_A459_Selumetinib_30min_R1 2 SETIQDTDTQSLVGSPSTR 19 0 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 SETIQDTDTQSLVGS(0.984)PS(0.009)T(0.006)R;SETIQDTDTQSLVGS(1)PSTR 327.31 5.0078999999999985e-138 6633000.0 2267.33 2472.0299999999997 1911.1399999999999 2004.1999999999998 2474.24 2036.53 2603.7 2511.8199999999997 1231.46 1925.35 True False 2320.1543775438167 2182.603578384432 1651.617685140578 1654.2040934934648 2250.4454288625525 2016.0443572212932 2407.3008127491025 2445.1983740587625 2089.697677720198 2172.487426997154 1.0679713717610648 1.0046564832834315 0.7602426898384722 0.7614332184098903 1.0358842131358859 0.9279889642481849 1.1080850378390963 1.1255293557388055 0.9618917245512488 1.0 11.085132112306438 -6.847414044393178 1.8960673884278285 1.0535969815585233 0.904061186982575 0.21982125546856235 0.10757786538462003 0.4989827067137933 3.6863941107608706 0.04892470613362072 0.04213244117772731 1.4209734242312713e-07 6.847414044393178 -0.14953579457594834 SETIQDTDTQSLVGS(ph)PSTR ddPTM_A459_Selumetinib_30min_R2 4 SETIQDTDTQSLVGSPSTR 19 0 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 SETIQDTDTQSLVGS(0.996)PS(0.003)T(0.001)R;SETIQDTDTQSLVGS(0.999)PS(0.001)TR;SETIQDTDTQSLVGS(1)PSTR;SETIQDTDTQSLVGS(0.999)PS(0.001)TR 319.36 5.244199999999998e-135 37430400.0 122821.0 93478.0 115102.0 128201.0 132204.0 88570.0 119990.0 117604.0 113205.0 122834.0 True False 115995.10051141852 100647.46202085588 107696.46263358227 110739.80264093982 115595.35160124445 100769.71354159109 125569.77275567432 117946.20816960982 135849.16321198054 119287.46325894014 0.9723997588885362 0.8437388076765286 0.9028313595688005 0.9283440155027379 0.9690486195545869 0.8447636556982343 1.052665295456045 0.9887561102173928 1.1388385627506348 1.0 16.864082902679087 -7.277553727297 24.54291055141943 1.0441280198051923 0.9103337029455726 0.588940758573453 0.0552004636076166 459.6591582898366 700079.4028472743 0.02208359312936109 0.014943427855950174 5.277719111965669e-08 7.277553727297 -0.13379431685961973 SETSWES(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 SETSWESPK 9 0 E5RJU9;Q86UE4 E5RJU9 MTDH Protein LYRIC 1 SETS(0.001)WES(0.999)PK;SETSWES(1)PK;SETSWES(1)PK 128.51 0.004305600000000001 74985000.0 476739.0 281691.0 436172.0 439366.0 374281.0 309231.0 479625.0 387289.0 352866.0 381655.0 True False 450243.7549174264 303295.79392067523 408109.16838816577 379523.59285137383 327260.4746654059 351824.7633304709 501928.51285890694 388415.9468708546 423449.0598998169 370635.62849122274 1.2147881107660132 0.8183125706379785 1.1011061458108862 1.0239803291343903 0.8829709005516073 0.9492470131991174 1.3542370842818028 1.0479725018666222 1.1424942108873508 1.0 18.49964204597193 SEVIEDS(ph)DVETVSEK ddPTM_A459_Selumetinib_30min_R2 1 SEVIEDSDVETVSEK 15 0 E5RFE4;Q56NI9 E5RFE4 ESCO2 N-acetyltransferase ESCO2 1 SEVIEDS(1)DVETVSEK 144.4 0.00037347 2292700.0 13251.0 9681.1 14556.0 13618.0 12353.0 15103.0 18712.0 16238.0 14519.0 14509.0 True False 12514.562467955868 10423.609240357173 13619.482807374494 11763.204907639689 10801.105702778823 17183.301158616374 19582.14507712459 16285.249891654385 17423.205694755055 14090.08747109076 0.8881820282260515 0.7397831462539706 0.9666003021853607 0.8348567694682353 0.766574779960729 1.2195311912628004 1.3897816544646813 1.155794804330884 1.2365576672609733 1.0 13.782392947457975 -6.7684867273497415 24.99985403387604 1.2219108591318955 0.8405128405682047 0.736468929576676 0.10762541261837273 78.21102377560379 277445.1337417047 0.036316256574397354 0.0327034895215911 1.7041714003948319e-07 6.7684867273497415 -0.3813980185636907 SEVLSESS(ph)ELLQQELEELRK ddPTM_A459_Selumetinib_30min_R1 2 SEVLSESSELLQQELEELRK 20 1 H0YJ97;Q15643-2;Q15643 H0YJ97 TRIP11 Thyroid receptor-interacting protein 11 1 S(0.002)EVLS(0.159)ES(0.129)S(0.71)ELLQQELEELRK;S(0.001)EVLS(0.04)ES(0.15)S(0.809)ELLQQELEELRK 85.51 0.001235 7566500.0 711.38 1186.64 1124.24 1197.3200000000002 836.5 793.71 1011.77 1074.6 534.48 640.0 True False 727.9537698954807 1047.7076371460312 971.5743830082791 988.2305384799898 760.8387226960704 785.7259980310195 935.4513743193003 1046.098117207262 906.9735231253082 722.1502341279138 1.0080364659502956 1.4508167243222851 1.3453909409606106 1.36845560906506 1.0535740165131675 1.0880367559250068 1.2953694814611174 1.4485879360969198 1.2559346798808306 1.0 9.49615519237823 -11.496507773471793 2.7033363718793835 0.775577418741333 1.2644952736802069 0.20535289683269387 0.15112268449057742 6472000.58526603 7014141.591347633 9103696.44307926 0.039017452064527995 3.187808516344726e-12 11.496507773471793 0.48891785493887385 SEVQAIIESTPELDMDKDLS(ph)GYKGSSTPTK ddPTM_A459_Selumetinib_30min_R1 1 SEVQAIIESTPELDMDKDLSGYKGSSTPTK 30 2 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;H0YBE9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 SEVQAIIES(0.001)T(0.001)PELDMDKDLS(0.452)GY(0.12)KGS(0.14)S(0.14)T(0.14)PT(0.009)K 62.107 0.00063376 44852000.0 2465.5 1525.6 2153.5 2166.2 1805.4 1724.6 1729.5 2103.6 1169.8 1367.3 True False 2522.94135297212 1346.9820427678014 1861.066528328764 1787.9138346100908 1642.101888769258 1707.2520898115126 1599.042422571561 2047.805694544199 1985.0651611884164 1542.806273629838 1.6352936827488191 0.8730727025102698 1.2062865961454377 1.158871249857946 1.0643603910851376 1.106588765545252 1.0364505575994407 1.3273252316547972 1.2866587303395218 1.0 10.591341202293288 -4.742307675937099 24.99513255989257 1.1274601885550677 1.6352953778014618 0.5911458305183361 0.1288990335248544 969.3157764792429 1266323.105940941 0.03216255765726687 1.1639563931343309 1.810057303133239e-05 4.742307675937099 0.5078351892463941 SEVQAIIESTPELDMDKDLSGYKGS(ph)STPTK ddPTM_A459_Selumetinib_30min_R1 1 SEVQAIIESTPELDMDKDLSGYKGSSTPTK 30 2 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;H0YBE9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 SEVQAIIESTPELDMDKDLS(0.018)GY(0.167)KGS(0.271)S(0.271)T(0.271)PT(0.003)K 75.005 1.8517e-05 39759000.0 1750.6 1277.0 1831.6 1962.2 1933.6 1348.1 1525.3 1513.7 840.15 1034.7 True False 1791.385573925367 1127.488246338806 1582.878780258632 1619.5386050558213 1758.7062214048067 1334.5393379768645 1410.2453929739256 1473.5517588094488 1425.673187871815 1167.5138238314892 1.5343591976037478 0.9657172560395652 1.3557687694557814 1.387168675862783 1.5063686489237202 1.143060844964764 1.2079046639001259 1.262127889821141 1.2211188927880194 1.0 10.189223916785517 -9.12402650456072 0.48061722724292283 0.9803906841697282 1.3137599413206869 0.2615505168402923 0.15690599542473838 3.5002581325838897 1.373737500627242 0.3121439996999956 0.08708229032613704 7.515770246194859e-10 9.12402650456072 0.33336925715095866 SEVQQPVHPKPLS(ph)PDSR ddPTM_A459_Selumetinib_30min_R1 2 SEVQQPVHPKPLSPDSR 17 1 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VRN8;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 SEVQQPVHPKPLS(0.744)PDS(0.256)R;SEVQQPVHPKPLS(0.98)PDS(0.02)R 82.146 0.0080833 12476300.0 2427.7799999999997 3031.96 3289.1800000000003 3544.4 3060.9 2570.19 2895.7200000000003 2362.19 2066.7 2276.08 True False 2484.3425503624644 2676.976713680038 2842.527422172464 2925.4370766281986 2784.042135445787 2544.3362221458056 2677.293509042455 2299.5370477255024 3507.0389542042244 2568.2370388966597 0.9673338218927653 1.0423402019114614 1.10680103865866 1.1390837497947603 1.084028496311166 0.9906936873859891 1.0424635532056055 0.8953757043833487 1.3655433283957634 1.0 11.326562648749526 -8.251982755284404 24.98594671150039 1.1827716806947557 1.0403257228817424 0.23999078089053305 0.10568979751269166 852.4197099493623 2252247.854217425 0.07047025333780753 0.02587418346285155 5.59779828469411e-09 8.251982755284404 -0.14244595781301328 SEVQQPVHPKPLS(ph)PDSR ddPTM_A459_Selumetinib_30min_R2 4 SEVQQPVHPKPLSPDSR 17 1 Q9UHB6;Q9UHB6-4;F8VQE1;Q9UHB6-2;Q9UHB6-5;F8VRN8;F8VS07;Q9UHB6-3 Q9UHB6 LIMA1 LIM domain and actin-binding protein 1 1 S(0.002)EVQQPVHPKPLS(0.96)PDS(0.038)R;SEVQQPVHPKPLS(0.974)PDS(0.026)R;SEVQQPVHPKPLS(0.996)PDS(0.004)R;SEVQQPVHPKPLS(0.946)PDS(0.054)R 132.67 0.00037894 212417000.0 253226.0 270264.0 250678.0 271624.0 252401.0 202332.0 210879.0 209347.0 169449.0 252359.0 True False 239152.71266399487 290992.3797642714 234549.65039756952 234628.34262246513 220692.12988643046 230201.39641297545 220685.29134881098 209956.16511073822 203343.53480064365 245072.73996257395 0.9758437951953238 1.187371471052676 0.9570613624077021 0.957382459829258 0.9005168421430031 0.9393186547313684 0.9004889380292265 0.8567095840312614 0.8297272672256288 1.0 17.902850493084657 -5.4632699025445435 5.0669895055686585 0.9091828397665606 1.0825305838552515 0.5068537622737127 0.06580071507493125 0.1531754544328151 8.056909754249986 0.017077872229464473 0.035791859758565504 3.441359928658609e-06 5.4632699025445435 0.1733477440886909 SEVTSQSGLSNSSDSLDS(ph)STRPPSVTR ddPTM_A459_Selumetinib_30min_R1 1 SEVTSQSGLSNSSDSLDSSTRPPSVTR 27 1 Q9Y2H0-3;Q9Y2H0;Q9Y2H0-1 Q9Y2H0-3 DLGAP4 Disks large-associated protein 4 1 SEVTSQSGLSNS(0.001)S(0.001)DS(0.007)LDS(0.237)S(0.237)T(0.237)RPPS(0.237)VT(0.045)R 56.07899999999999 0.0048771 4344000.0 463.66 548.87 648.32 694.57 608.98 506.22 602.38 445.57 206.31 393.83 True False 474.46237587469193 484.60804523725943 560.2817049668469 573.2763881936709 553.8978665241517 501.12788641098484 556.94199162108 433.7520361846641 350.09300171378214 444.38191672905685 1.0676905562833137 1.0905215243777096 1.2608112163764194 1.290053367637824 1.2464455588139236 1.1276963970532727 1.2532958040249236 0.9760794034495471 0.7878200901843551 1.0 8.79565629998481 -7.894617433149803 4.626935512529971 0.8900721524354879 1.1926542927443096 0.6772406852107501 0.08627774412157072 0.12125354026480391 4.34415036462972 0.05229222567104192 0.023916718416082478 1.2746253948641752e-08 7.894617433149803 0.3025821403088217 SEWLDPS(ph)QKSPLHVGETR ddPTM_A459_Selumetinib_30min_R2 2 SEWLDPSQKSPLHVGETR 18 1 O15164-2;O15164 O15164-2 TRIM24 Transcription intermediary factor 1-alpha 1 S(0.001)EWLDPS(0.554)QKS(0.444)PLHVGET(0.001)R;SEWLDPS(0.5)QKS(0.5)PLHVGETR 95.751 0.0021586 23868600.0 62993.0 53417.0 64607.0 63389.0 66082.0 51754.0 51950.0 52181.0 38643.3 60070.0 True False 59492.10124095872 57513.91213727357 60450.25595878295 54755.30884787576 57780.188379424515 58882.64372396421 54365.777936972125 52332.83807097041 46373.03978401598 58335.62301939637 1.0198245627920666 0.9859140806321793 1.0362494275356153 0.9386255946845692 0.990478637045032 1.009377129723736 0.9319481840263489 0.8970991542092546 0.7949351936911194 1.0 15.832089522982965 -7.508394998290193 2.773387303532935 0.884766605785297 0.9950500548510613 0.4227519399931948 0.05235032460264444 0.23854196774999772 3.688364957808939 0.026072626050924384 0.014647679180508213 3.101737221552897e-08 7.508394998290193 0.11028344906576437 SEWLDPSQKS(ph)PLHVGETR ddPTM_A459_Selumetinib_30min_R2 2 SEWLDPSQKSPLHVGETR 18 1 O15164-2;O15164 O15164-2 TRIM24 Transcription intermediary factor 1-alpha 1 SEWLDPS(0.186)QKS(0.811)PLHVGET(0.003)R;SEWLDPS(0.015)QKS(0.985)PLHVGET(0.001)R 80.016 0.0063882 24820000.0 33247.0 36946.0 40772.0 31650.0 36644.0 25820.0 28017.0 30233.0 23850.0 37806.0 True False 31399.264838286086 39779.639399885986 38148.77390919712 27339.21540070465 32040.45311848354 29376.47062937658 29319.846014632305 30320.973024657433 28620.66642467855 36714.44254821538 0.8552292411099769 1.0834874953540483 1.0390672242700703 0.7446447093620261 0.87269343873072 0.8001339143525826 0.7985916162591303 0.8258595506342851 0.7795478955479809 1.0 15.164060074605151 -5.753225859216929 24.9984931014459 0.8234038262583581 1.0016839721713093 0.4256222581353155 0.08511376813094515 148.64147485884445 452397.0977489886 0.021768004829162198 0.03690021876985058 1.7651196137226328e-06 5.753225859216929 0.17828014591295127 SEYQWIT(ph)SPSVKEPSK ddPTM_A459_Selumetinib_30min_R1 1 SEYQWITSPSVKEPSK 16 1 A0A2R8Y589;A0A2R8Y4C1;A0A2R8Y7U5;A8MST6;A0A2U3TZI9;A0A2R8Y5W6;A0A2R8Y432;A0A2R8YCP0;A0A2R8Y7A4;Q5JTW2;Q5JTW2-3;Q5JTW2-5;Q5JTW2-2 A0A2R8Y589 CEP78 Centrosomal protein of 78 kDa 1 SEYQWIT(0.5)S(0.5)PSVKEPSK 85.855 0.022115 14377000.0 1336.4 1103.3 1822.2 2009.3 1373.0 1483.7 1324.9 1315.8 698.74 1148.6 True False 1367.5355198182685 974.1251230897459 1574.7552486281284 1658.413474232321 1248.8123924228378 1468.7753250918136 1224.9617263168902 1280.9007096792443 1185.710746049576 1296.0339983114402 1.0551694798130182 0.751620038022846 1.2150570514969707 1.2796064581585151 0.9635645315245388 1.1332845642980294 0.9451617225418872 0.9883233860748155 0.9148762668220118 1.0 10.339887848989536 -7.282299350781655 24.020909634559374 0.9611172775853727 1.0638524793117654 0.12261200800836791 0.13656516315622785 1244.5671784418753 1433149.9937934207 0.0604295350574632 0.040801039778601084 5.2203623548450615e-08 7.282299350781655 0.10273520172639272 SEYQWITS(ph)PSVKEPSK ddPTM_A459_Selumetinib_30min_R1 1 SEYQWITSPSVKEPSK 16 1 A0A2R8Y589;A0A2R8Y4C1;A0A2R8Y7U5;A8MST6;A0A2U3TZI9;A0A2R8Y5W6;A0A2R8Y432;A0A2R8YCP0;A0A2R8Y7A4;Q5JTW2;Q5JTW2-3;Q5JTW2-5;Q5JTW2-2 A0A2R8Y589 CEP78 Centrosomal protein of 78 kDa 1 SEYQWIT(0.094)S(0.892)PS(0.013)VKEPSK 85.49600000000002 0.0089413 11260000.0 1499.1 1256.7 1984.6 1977.2 1607.6 1219.1 1356.2 1089.3 902.4 1032.5 True False 1534.0261132591786 1109.5649797760195 1715.1022206274743 1631.9191366406947 1462.192863844833 1206.836960854237 1253.9007421171152 1060.4082254549335 1531.3068913117015 1165.0314324016742 1.316725086203755 0.9523905955813463 1.4721510277983205 1.4007511653797586 1.2550673082103632 1.0358836056177319 1.076280611186807 0.9101970950851829 1.3143910530851193 1.0 10.186153163797677 -6.721039958919575 6.238248081614853 1.0621854740999803 1.2802735638402478 0.30867663123930533 0.15875465508340014 0.2442640424575171 24.434015892245284 0.05382159246770919 0.052883459571496906 1.9009033720148657e-07 6.721039958919575 0.2180880897402675 SEYQWITS(ph)PSVKEPSK ddPTM_A459_Selumetinib_30min_R2 1 SEYQWITSPSVKEPSK 16 1 A0A2R8Y589;A0A2R8Y4C1;A0A2R8Y7U5;A8MST6;A0A2U3TZI9;A0A2R8Y5W6;A0A2R8Y432;A0A2R8YCP0;A0A2R8Y7A4;Q5JTW2;Q5JTW2-3;Q5JTW2-5;Q5JTW2-2 A0A2R8Y589 CEP78 Centrosomal protein of 78 kDa 1 SEYQWIT(0.019)S(0.976)PS(0.005)VKEPSK 88.264 0.0077424999999999985 4370500.0 25554.0 25363.0 26016.0 36186.0 30280.0 20359.0 16942.0 21272.0 12077.0 27720.0 True False 24133.810980767048 27308.26054510119 24342.15888407906 31257.40437566823 26475.95569336541 23163.267449398845 17729.83656993611 21333.89799823083 14492.737459574133 26919.651574790525 0.8965127543986365 1.0144358841061147 0.9042523754978607 1.1611370336211886 0.9835177702730512 0.860459407694956 0.658620581350302 0.7925027535723905 0.5383701724113755 1.0 14.716372116593709 -6.956957766928858 3.2117150459355495 0.7309109146247896 0.9975389879983276 0.4427102442259604 0.12861704011102526 0.2100033943809578 4.456802006972602 0.04733336965733316 0.03960810659134819 1.1041859915130955e-07 6.956957766928858 0.266628073373538 SFAANGIQAHPES(ph)STGSDAR ddPTM_A459_Selumetinib_30min_R1 1 SFAANGIQAHPESSTGSDAR 20 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 S(0.005)FAANGIQAHPES(0.332)S(0.332)T(0.332)GSDAR 80.87100000000002 0.0039271 9408400.0 1114.6 1696.7 2635.1 2982.2 2051.0 1898.2 1734.9 1321.1 789.64 1205.6 True False 1140.5680113659391 1498.04957522557 2277.2678935682043 2461.4147528271683 1865.4874121334606 1879.1058314277022 1604.035096223996 1286.0601364624185 1339.9614069762529 1360.3505035384585 0.8384368649103044 1.101223229843292 1.6740302500309425 1.8093974651567302 1.3713284975313873 1.3813394610726353 1.1791336806592716 0.9453888046626215 0.9850118800197664 1.0 10.40976270420133 -7.501840623113542 2.5800113941680887 0.9721647536055803 1.386617681307155 0.31318859945899447 0.25437555695128905 0.3809535583366437 5.057038905583404 0.15169380244042877 0.084335198921833 3.148903683120476e-08 7.501840623113542 0.4144529277015746 SFCPIELNINGS(ph)PGAESDLATFCTSK ddPTM_A459_Selumetinib_30min_R1 1 SFCPIELNINGSPGAESDLATFCTSK 26 0 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 SFCPIELNINGS(0.998)PGAES(0.002)DLATFCTSK 117.82 5.1337e-09 4359300.0 1073.9 1171.1 1156.2 1263.7 1060.5 767.24 1090.9 877.96 646.97 983.61 True False 1098.9197805543542 1033.9870675703798 999.1943905519937 1043.018517586913 964.5779622464823 759.5222621981828 1008.6125347113716 854.6736487840021 1097.8608371807748 1109.8659246727457 0.990137417614998 0.9316324112529724 0.9002838706365506 0.9397698356172677 0.8690941318257853 0.6843369503592382 0.9087697101870844 0.7700692757424827 0.9891832993291413 1.0 10.116169689622394 -6.3128410185388795 5.199320635221221 0.8505622856645195 0.9371066553455785 0.10358687218519091 0.09133338810965214 0.3794244046406822 23.431166213653263 0.027618559021450335 0.031889863141095036 4.865852965657261e-07 6.3128410185388795 0.08654436968105894 SFELPPYTPPPILS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 SFELPPYTPPPILSPVR 17 0 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 SFELPPYTPPPILS(1)PVR;SFELPPYT(0.004)PPPILS(0.996)PVR 216.34 1.0550999999999996e-11 33600000.0 9084.4 11876.6 9960.1 10503.8 10921.7 9637.7 11291.0 10485.6 5662.9 9078.1 True False 9296.048844834688 10486.082150718452 8607.57312691308 8669.508510745758 9933.83416338275 9540.753488331451 10439.310779563746 10207.487825971026 9609.527698148306 10243.362563182216 0.9075192630833488 1.0236953037675973 0.8403073769790532 0.8463537688206633 0.9697825398749423 0.9314083563364087 1.0191292864206358 0.9964977577441089 0.9381223830432297 1.0 13.322401762553623 -6.792665259213347 2.0007188262982214 0.9855446783493171 0.9110581021077345 0.2812350252682093 0.053790695189071584 0.46800070906313224 3.8568070554092713 0.022920035047243544 0.020596565715569302 1.6118875496911912e-07 6.792665259213347 -0.07448657624158261 SFELPPYTPPPILS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 SFELPPYTPPPILSPVR 17 0 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 SFELPPYT(0.461)PPPILS(0.538)PVR 107.75 0.0024132 10397000.0 29433.0 26294.0 28352.0 22533.0 30091.0 21291.0 25433.0 22739.0 20347.0 24537.0 True False 27797.23168963437 28310.665251464354 26527.863187323564 19463.96652840689 26310.69956304686 24223.641989545195 26615.684894533424 22805.166725355906 24416.96854268071 23828.553055217708 1.1665513900579727 1.188098378691324 1.1132804885739713 0.8168337575220452 1.1041669001922734 1.0165804836496766 1.116966054667991 0.9570520993242722 1.0246937145574668 1.0 14.540403728751139 -5.533259093656368 24.99273411133516 1.0089907166479655 1.1706660720442015 0.4517231285215966 0.0781312575479226 176.84855689740243 425796.28497585276 0.020820532041178206 0.03610851703595315 2.9291452392133663e-06 5.533259093656368 0.161675355396236 SFETFSHR ddPTM_A459_Selumetinib_30min_R1 3 SFETFSHR 8 0 P30838;A8MYB8;I3L3I9 P30838 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 0 ;; 224.51 0.00022805 41890800.0 21164.7 24284.4 21309.3 23278.9 25981.7 21669.699999999997 24605.800000000003 22204.9 11075.6 18697.9 False True 21657.796330662764 21441.171158488738 18415.614103606284 19213.677114072965 23631.65982244171 21451.722492513352 22749.76469575678 21615.953920319684 18794.484270181605 21097.957597969256 1.0265352098701437 1.01626762016777 0.8728624094580058 0.9106889624198667 1.1200922986363537 1.0167677318006434 1.0782922749805184 1.0245519652765007 0.8908200797593143 1.0 14.364815724173916 -5.01963736840848 24.710982256900426 0.9927250211950771 1.023968410899084 0.02750566457485959 0.07528364768066353 3079.077394814922 3874636.1159808 0.020546888908404008 0.05626515103227888 9.557903283804955e-06 5.01963736840848 0.031243389704006974 SFETFSHR ddPTM_A459_Selumetinib_30min_R2 5 SFETFSHR 8 0 P30838;A8MYB8;I3L3I9 P30838 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 0 ;;;; 224.51 0.00022805 67252500.0 588001.0 463847.0 553234.0 606945.0 638793.0 439509.0 429371.0 463125.0 422963.0 475796.0 False True 555322.2583745017 499422.5733968206 517639.52675563435 524278.0439614742 558542.1124581232 500047.37528453383 449337.60228249524 464472.6170755293 507567.41857363895 462058.5332135302 1.2018439623056842 1.0808643007270757 1.12028994066087 1.1346572052575656 1.2088124605633142 1.0822165144463374 0.9724690055120002 1.0052246278089696 1.0984916024461295 1.0 18.81771609713423 -7.000796754286522 8.826620690975949 1.0205002618852728 1.1433957265363606 0.6387420333046057 0.0461091487996685 0.07189708561859123 72.92754786436603 0.016828869412853734 0.014209434158046819 9.981670872969877e-08 7.000796754286522 0.1228954646510878 SFEVEEVETPNS(ph)TPPRR ddPTM_A459_Selumetinib_30min_R1 1 SFEVEEVETPNSTPPRR 17 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7EJV0;K7EPY1 Q9UHD8 SEPT9 Septin-9 1 SFEVEEVET(0.032)PNS(0.484)T(0.484)PPRR 90.581 0.0045708 1994200.0 676.16 713.26 713.85 795.27 715.96 592.08 686.86 849.95 394.28 527.04 True False 691.9132124216703 629.7511876144223 616.913090897371 656.3910235667839 651.2015444130043 586.1242127656276 635.0495972058415 827.4065649733045 669.0643629281667 594.690717804337 1.1634841299966634 1.058955804690432 1.0373679501423554 1.1037519233363036 1.0950255736583738 0.9855950248049307 1.067865325947097 1.3913224810842513 1.1250627307559553 1.0 9.215995747442498 SFFDNISCDDNR ddPTM_A459_Selumetinib_30min_R2 1 SFFDNISCDDNR 12 0 Q8ND56-3;Q8ND56-2;Q8ND56;A0A0G2JQ95;A0A096LP11;A0A140TA76 Q8ND56-3;A0A140TA76 LSM14A Protein LSM14 homolog A 0 133.91 0.033389 0.0 12086.0 9670.1 10850.0 13379.0 10893.0 11508.0 8886.8 9330.6 8513.9 12194.0 False True 11414.30850409136 10411.765575727746 10151.922812586792 11556.757119937685 9524.523955344432 13093.122540777144 9300.05380886013 9357.75050123602 10216.917898241956 11841.927536183104 0.963889406451344 0.8792289552452093 0.8572863481529938 0.9759185812128913 0.8043052050641395 1.1056580527765436 0.7853496637640909 0.7902219020208778 0.8627749044253211 1.0 13.531616310225601 SFGDKDLILPNGGTPAGTS(ph)SPASSSSLLNR ddPTM_A459_Selumetinib_30min_R1 1 SFGDKDLILPNGGTPAGTSSPASSSSLLNR 30 1 Q5VWJ9 Q5VWJ9 SNX30 Sorting nexin-30 1 SFGDKDLILPNGGTPAGT(0.04)S(0.437)S(0.437)PAS(0.04)S(0.015)S(0.015)S(0.015)LLNR 110.61 2.2647e-11 10634000.0 1191.6 1054.5 1460.5 1771.2 1412.1 1185.7 1152.5 1233.2 565.49 958.45 True False 1219.3619615500218 931.0386497762505 1262.1721219522458 1461.8931695417748 1284.3758043265032 1173.7729345294624 1065.5659971169268 1200.4915300018574 959.5952282445182 1081.4763935935928 1.127497529093774 0.8608959523217525 1.1670824526814003 1.3517568928935295 1.1876133514654947 1.08534309346243 0.9852882628128405 1.110048760299607 0.8873011319793299 1.0 10.07878645923877 -7.072005607485762 4.120907075963072 1.0057636026882133 1.1371493689792151 0.229421616164447 0.1230757232765039 0.4304756726914965 13.952732671703028 0.05301373443919136 0.04137411108457563 8.47216475053895e-08 7.072005607485762 0.13138576629100185 SFGPVQS(ph)MTFVLETR ddPTM_A459_Selumetinib_30min_R1 1 SFGPVQSMTFVLETR 15 0 H3BQP3;Q96IC2-2;Q96IC2 H3BQP3 LOC81691;44M2.3 Putative RNA exonuclease NEF-sp 1 SFGPVQS(0.997)MT(0.002)FVLETR 75.589 0.031913 235890000.0 4235.4 4336.3 6188.9 5848.5 2847.9 3911.8 2490.7 4076.6 3985.6 4395.2 True False 4334.076579346222 3828.6039801088214 5348.481373194285 4827.169264941884 2590.307947837583 3872.450843630221 2302.8244937259246 3968.4753253369868 6763.272103293347 4959.366732873452 0.8739173392073514 0.7719945279970316 1.0784605497596222 0.973343881375965 0.5223061909633695 0.780835750250421 0.46433841612509075 0.8001979968595015 1.3637370389373713 1.0 12.275940197679363 -8.222606997041414 12.452771872127522 1.1817702748934522 0.779530882293299 0.4085887083966956 0.19182781865946227 1.514323304908423 485.54195067869495 0.13620631224019664 0.05128082789334211 5.989533564180331e-09 8.222606997041414 -0.4022393926001532 SFGS(ph)PNR ddPTM_A459_Selumetinib_30min_R1 2 SFGSPNR 7 0 D6R9G1;D6RAD4;P50613;D6REC6 D6R9G1 CDK7 Cyclin-dependent kinase 7 1 SFGS(1)PNR;SFGS(1)PNR 135.55 0.0051157 42085300.0 14942.5 16155.4 17303.0 18340.0 17224.9 13862.9 15805.8 14240.7 8042.700000000001 12867.3 True False 15290.631176956364 14263.918257558293 14953.347638575622 15137.263284437757 15666.910836303097 13723.451812506104 14613.555780677407 13862.990375687197 13647.87448443331 14518.943293115792 1.0531504165462557 0.9824350140083252 1.029919832090384 1.0425871207593422 1.0790668797316412 0.9452100979699485 1.0065164857835402 0.9548208912876176 0.9400046689971231 1.0 13.825648835551302 -6.773128114258613 24.99995951615044 0.9688121098477378 1.0342455460203488 0.5588751949673978 0.030192653208104873 181.4820044056035 388153.12486125977 0.01080468451811426 0.009605717518928164 1.6860555757717177e-07 6.773128114258613 0.06543343617261099 SFGTRPLS(ph)SGFSPEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R1 2 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.004)FGT(0.011)RPLS(0.414)S(0.414)GFS(0.158)PEEAQQQDEEFEK;S(0.004)FGT(0.011)RPLS(0.441)S(0.441)GFS(0.103)PEEAQQQDEEFEK 101.98 1.3225e-06 671515000.0 4491.9 5658.0 6088.6 6100.700000000001 5341.5 5161.1 5446.0 4843.3 2542.62 3886.7999999999997 True False 4596.552530284104 4995.558729667159 5261.801562285817 5035.327269322212 4858.362268118422 5109.184019903862 5035.203835400247 4714.839950744403 4314.640434382709 4385.708640638088 1.048075215871007 1.1390539452115411 1.199760858149543 1.1481217020813332 1.1077713241369282 1.164962025192926 1.1480935575026394 1.0750463236560168 0.9837955021460252 1.0 12.09859425611985 -8.045248597590653 2.86324802489028 0.9920915271561119 1.1393674272190237 0.6997796773152297 0.037638561474350685 0.15394202901550474 2.3823781293501076 0.030538770480120853 0.010483025309982056 9.010552105409875e-09 8.045248597590653 0.1472759000629118 SFGTRPLS(ph)SGFSPEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R2 1 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.012)FGT(0.012)RPLS(0.369)S(0.303)GFS(0.303)PEEAQQQDEEFEK 59.789 0.0042207 4966100.0 8869.5 10534.0 9932.5 12673.0 10401.0 10571.0 9480.1 10180.0 7256.7 11264.0 True False 8376.568697421671 11341.923927851434 9293.453763688327 10946.915537855612 9094.333393880237 12027.059296016267 9920.943434461778 10209.622114610273 8708.242769138991 10938.779052613289 0.7657681590543232 1.0368546501669977 0.8495878487890391 1.0007438202383638 0.8313846865485037 1.0994882736152338 0.9069516247420366 0.933342017925774 0.7960890998212987 1.0 13.41716409820643 -4.737892386118346 24.599067316850423 0.9370257507911005 0.7657672698906988 0.24383378090699148 0.0916363600339216 2424.890447246217 2533074.0049947645 0.021302040460127538 1.2269172408261404 1.8285532574413784e-05 4.737892386118346 -0.17125848090040174 SFGTRPLSS(ph)GFSPEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R1 1 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.005)FGT(0.005)RPLS(0.171)S(0.661)GFS(0.158)PEEAQQQDEEFEK 91.592 2.0029e-05 620130000.0 1429.4 1531.7 1933.7 1929.2 1947.8 1459.9 1645.7 1351.6 889.43 1297.1 True False 1462.70223887177 1352.3678519319883 1671.114161053787 1592.3014355691012 1771.6218339120198 1445.2147314831427 1521.563524039328 1315.7511773844562 1509.2977486030209 1463.595419823934 0.9993897350729128 0.924003883596926 1.141786957255453 1.0879382471425403 1.2104587168803387 0.9874414144156024 1.0396066449991812 0.8989855800059398 1.0312260670948155 1.0 10.515301090688377 -6.909683019323727 20.832081150238643 0.9880173688537666 1.0721205945950827 0.20425759596100324 0.08004426256715778 9.66937136804264 2222.001078769071 0.029935384763207916 0.026400564220521464 1.231167040979399e-07 6.909683019323727 0.08410322574131612 SFGTRPLSS(ph)GFSPEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R2 1 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.023)FGT(0.007)RPLS(0.207)S(0.586)GFS(0.176)PEEAQQQDEEFEK 67.083 0.0010254 98790000.0 72195.0 70584.0 89460.0 90297.0 84139.0 73251.0 81056.0 74363.0 66610.0 83907.0 True False 68182.69091948343 75997.56583666845 83704.24099668325 77998.39282898653 73568.70660779621 83340.66034362759 84825.26460941698 74579.38401854265 79933.86123890299 81484.38689343263 0.8367577338300956 0.9326641425928628 1.0272426925928007 0.9572188710334757 0.9028564785547353 1.0227807254980348 1.041000219101527 0.9152598045080647 0.9809715000180653 1.0 16.314236032644494 -4.847685719096061 3.322753324864113 0.9780977617503541 0.8275459239353029 0.5010083143189588 0.04368601208057858 0.24116292494178537 4.3870380554077775 0.011430107014553341 0.08484386419553341 1.4200848064181527e-05 4.847685719096061 -0.15055183781505121 SFGTRPLSSGFS(ph)PEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R1 1 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.004)FGT(0.004)RPLS(0.096)S(0.359)GFS(0.538)PEEAQQQDEEFEK 93.679 8.5654e-06 19116000.0 1798.5 2155.4 2064.4 2232.8 1843.4 1931.6 1865.1 1608.1 1118.1 1659.1 True False 1840.4015507281918 1903.0447659817241 1784.0658189374983 1842.8833948469257 1676.664795478703 1912.1698577524753 1724.4140053993751 1565.447964155033 1897.334037207018 1872.0616460025342 0.983088112861055 1.016550266945188 0.9529952300166312 0.9844138406350488 0.8956247776663404 1.0214246212647886 0.9211309943139772 0.8362160335359565 1.0134997644219936 1.0 10.870412227552324 -5.629677873135576 1.314556676895168 0.9422799427046031 1.000372302166982 0.07926971909650915 0.05555977624023815 1.0819172700766577 3.567098434038778 0.018343804202224836 0.05548016808494991 2.3459682323079e-06 5.629677873135576 0.058092359462378784 SFGTRPLSSGFS(ph)PEEAQQQDEEFEK ddPTM_A459_Selumetinib_30min_R2 2 SFGTRPLSSGFSPEEAQQQDEEFEK 25 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 S(0.111)FGT(0.122)RPLS(0.101)S(0.101)GFS(0.564)PEEAQQQDEEFEK;S(0.013)FGT(0.004)RPLS(0.216)S(0.216)GFS(0.55)PEEAQQQDEEFEK 55.718 0.0069559 327970000.0 64163.0 72235.0 60640.0 73222.0 71056.0 65472.0 58392.0 61855.0 51944.0 69577.0 True False 60597.07732483981 77775.19222786662 56738.488419839916 63249.0372850047 62129.31003130029 74490.17370435873 61107.343701552934 62034.98780935348 62334.251436624836 67568.13122724387 0.8968292629115472 1.1510632426149918 0.8397226235104549 0.9360779429030933 0.9195061177931377 1.1024453740452698 0.9043811422878911 0.9181101605536282 0.9225392252892634 1.0 16.04405533372988 SFIS(ph)PASIR ddPTM_A459_Selumetinib_30min_R1 3 SFISPASIR 9 0 C9IYV0;Q8N8L2 C9IYV0 ZNF491 Zinc finger protein 491 1 SFIS(0.817)PAS(0.183)IR;SFIS(0.867)PAS(0.133)IR;SFIS(0.983)PAS(0.017)IR 88.948 0.020188 66634100.0 14028.100000000002 21229.9 12924.8 15653.9 15242.2 14801.2 15509.2 14076.4 8294.1 13040.0 True False 14354.92743606904 18744.29343848726 11169.68315084449 12920.240225095975 13863.54570122897 14652.313366414352 14339.328557471445 13703.048145408804 14074.481922903795 14713.81102035626 0.9756090666251788 1.2739251178742823 0.7591291702327466 0.878102906665111 0.9422131140633134 0.9958204129537326 0.9745489144609288 0.9313051612835664 0.9565490479272865 1.0 13.84488334660931 -5.257585823987881 24.999988838323446 0.9298213115932588 1.1247670762429611 0.40765010622022824 0.0940523731813535 309.4379121026547 2007460.4992118008 0.02364191097154516 0.057792410324284706 5.52604193151195e-06 5.257585823987881 0.19494576464970237 SFIS(ph)PASIR ddPTM_A459_Selumetinib_30min_R2 2 SFISPASIR 9 0 C9IYV0;Q8N8L2 C9IYV0 ZNF491 Zinc finger protein 491 1 SFIS(0.73)PAS(0.27)IR;SFIS(0.737)PAS(0.263)IR 88.819 0.020301 23002900.0 97909.0 100551.0 111898.0 118660.0 125620.0 90352.0 91366.0 89516.0 84860.0 101984.0 True False 92467.60974078128 108262.9383775765 104698.60450533037 102498.3033000825 109838.4925429513 102797.16786620572 95614.70003829442 89776.47673982833 101834.37118650805 99039.45693374616 0.9336441515691952 1.093129362068297 1.057140333224666 1.0349239229840506 1.109037710257532 1.0379415542935917 0.9654202779227397 0.9064718196090834 1.0282202097960977 1.0 16.59571578334699 -7.2253759077020225 5.2279400649108885 0.967003830478791 1.0502092385272876 0.28644177042772123 0.0526690932708994 0.21624347148312445 15.908733708023039 0.020255381604759284 0.015152010388498711 5.951467855878003e-08 7.2253759077020225 0.08320540804849663 SFIS(ph)PIPSK ddPTM_A459_Selumetinib_30min_R2 1 SFISPIPSK 9 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 SFIS(0.999)PIPS(0.001)K 104.52 0.014277 5551700.0 40945.0 36491.0 43322.0 45897.0 47361.0 36615.0 43543.0 39859.0 40581.0 33591.0 True False 38669.440815821676 39289.74236294156 40534.709685427166 39645.749423258836 41411.08776728795 41658.383892123325 45567.835778817636 39974.98309098732 48698.33392787755 32621.14055010061 1.1854104474499256 1.2044257711528845 1.2425902038333896 1.2153391559798348 1.2694555453598397 1.2770364000039491 1.3968805201287513 1.2254318033298817 1.4928458388229886 1.0 14.993519604186863 -6.392911307955137 1.79057004727264 1.300253840386974 1.20990935611135 0.05261218192701589 0.12010275408498974 0.8521318510050847 5.425486728005419 0.04112258762048682 0.04932469972635298 4.0465852301991656e-07 6.392911307955137 -0.0903444842756238 SFISPAS(ph)IR ddPTM_A459_Selumetinib_30min_R1 2 SFISPASIR 9 0 C9IYV0;Q8N8L2 C9IYV0 ZNF491 Zinc finger protein 491 1 SFIS(0.326)PAS(0.674)IR;SFIS(0.34)PAS(0.66)IR 96.711 0.01405 277540000.0 16182.3 24718.0 14787.0 18117.2 16850.7 18359.0 19265.8 16006.2 8494.7 15679.8 True False 16559.3161047255 21824.00506891355 12779.0066191769 14953.371121963772 15326.557160232724 18174.32512863827 17812.565195015442 15581.663580534972 14414.885471659465 17692.45506418574 0.9359535488235313 1.2335204464128426 0.7222856620416138 0.8451835015386527 0.8662764497425671 1.0272359072104111 1.006788776933103 0.8806953881757443 0.8147476096089711 1.0 14.11084663465362 -5.256610993791691 24.999889551530476 0.8969935690057713 1.0847369780308542 0.31431188758301065 0.11184013151613972 481.8823634016622 2495016.0295090703 0.029010673502049323 0.07181799868907886 5.538459779647988e-06 5.256610993791691 0.1877434090250829 SFISPAS(ph)IR ddPTM_A459_Selumetinib_30min_R2 1 SFISPASIR 9 0 C9IYV0;Q8N8L2 C9IYV0 ZNF491 Zinc finger protein 491 1 SFIS(0.346)PAS(0.654)IR 83.005 0.026394 12052000.0 32705.0 31430.0 40147.0 40123.0 39278.0 27279.0 32995.0 36727.0 26496.0 30938.0 True False 30887.387028488156 33840.579936621456 37563.985728748565 34658.17818396442 34343.54649022478 31036.434635893278 34529.33287835217 36833.86948951782 31795.9403600957 30044.739553422405 1.0280464230208235 1.1263396001968893 1.2502683094308813 1.1535522923185564 1.1430801864385838 1.0330072783858733 1.1492638442398788 1.2259673419376358 1.058286436584331 1.0 14.874824795293268 -6.561933425416789 24.999123368914 1.1083829699509318 1.1467415176992841 0.06439021318833027 0.07791296626978564 572.3498084167488 366360.3501444053 0.026464666317052 0.02646468507432415 2.7419944700335993e-07 6.561933425416789 0.038358547748352345 SFLGS(ph)PAAGTLAELQPPVQLPAEGCHR ddPTM_A459_Selumetinib_30min_R2 2 SFLGSPAAGTLAELQPPVQLPAEGCHR 27 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 S(0.066)FLGS(0.931)PAAGT(0.003)LAELQPPVQLPAEGCHR;S(0.083)FLGS(0.917)PAAGTLAELQPPVQLPAEGCHR 82.234 0.0011663 2513900.0 7030.4 10721.8 11386.9 9243.8 10729.4 7201.4 9754.3 10130.7 8024.0 8763.9 True False 6639.678512921059 11544.127583979256 10654.27925111931 7984.778493555571 9381.476849946988 8193.32748219956 10207.894277778769 10160.178659772337 9629.02420929228 8510.863435653204 0.7801415876450928 1.3563991093570227 1.2518446960959373 0.9381866544945617 1.1022943701160404 0.9626905124427868 1.1993958491939212 1.1937894123891026 1.1313804154059086 1.0 13.055089786860682 SFLSEPSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 2 SFLSEPSSPGR 11 0 Q69YN4-3;Q69YN4;H0YC41 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 SFLSEPS(0.001)S(0.999)PGR;SFLSEPS(0.002)S(0.998)PGR 191.33 1.9961e-05 283230000.0 12619.7 14626.1 15686.400000000001 16280.800000000001 14730.6 12651.0 14013.1 13444.0 6886.0 9953.7 True False 12913.714456338379 12913.66941251059 13556.273039227459 13437.663908466424 13398.219830898657 12523.742426188954 12956.080584988467 13087.421447733519 11685.03906645875 11231.354352248472 1.1497913832407136 1.1497873726978727 1.207002522942707 1.1964419861595994 1.1929300252392434 1.1150696553066861 1.1535635132369153 1.165257638328673 1.0403944795953706 1.0 13.455244287649451 -8.343274401406019 3.0639826062794504 1.0010738758270235 1.1677140929583478 0.8378648373984101 0.025953438919460295 0.10016784137324744 1.7297172894438648 0.026943678263224344 0.007365775299375347 4.536548921346951e-09 8.343274401406019 0.16664021713132438 SFLSEPSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 6 SFLSEPSSPGR 11 0 Q69YN4-3;Q69YN4;H0YC41 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 SFLSEPS(0.002)S(0.998)PGR;SFLSEPS(0.003)S(0.997)PGR;SFLSEPS(0.003)S(0.997)PGR;SFLSEPS(0.002)S(0.998)PGR;SFLSEPS(0.002)S(0.998)PGR;SFLSEPS(0.002)S(0.998)PGR 179.94 5.0623e-05 395721000.0 1064565.0 993789.0 1198184.0 1219153.0 1346452.0 909139.0 970704.0 1003339.0 865030.0 1044951.0 True False 1005400.7390913462 1070009.4207647184 1121094.1459241016 1053102.258243771 1177298.6623263955 1034364.6449078551 1015843.6594134859 1006258.5503782872 1038060.17095764 1014780.5495212479 0.9907568090122274 1.054424447994718 1.104765110499024 1.0377635428079526 1.1601509931204537 1.0192988478108362 1.0010476254129423 0.9916021260488476 1.02294054753747 1.0 19.952736341711976 -6.978624636485667 24.999280708224745 1.0041942141064244 1.07099929133758 0.3637861283270991 0.0417658125835935 255.66501309424783 299008.64350100624 0.014674477388292641 0.012940341436824286 1.0504499470551501e-07 6.978624636485667 0.0668050772311557 SFLVASVLPGPDGNINS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 SFLVASVLPGPDGNINSPTR 20 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 S(0.168)FLVASVLPGPDGNINS(0.831)PT(0.001)R 243.99 1.6165e-30 36253000.0 6421.0 8198.7 8296.9 9512.5 8769.7 6347.5 7468.4 6841.1 3926.2 6578.0 True False 6570.596806908937 7238.792392527779 7170.22655160944 7851.32044674014 7976.482183416288 6283.6499130688735 6905.052575156667 6659.651804975432 6662.474641697698 7422.350375145971 0.8852447640993661 0.9752695610769274 0.9660318078784347 1.057794371043247 1.0746571881227607 0.8465849219554388 0.930305391979137 0.897242984819948 0.8976233005662536 1.0 12.857660390326272 -6.7695044370042226 24.99998644463837 0.9089261488129653 0.9931160485431835 0.2894850263880372 0.06035125123145856 232.60073845230772 721009.283370641 0.021744978095087943 0.019510987139125868 1.7001825835026206e-07 6.7695044370042226 0.08418989973021818 SFLVASVLPGPDGNINS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 SFLVASVLPGPDGNINSPTR 20 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 SFLVASVLPGPDGNINS(0.916)PT(0.084)R;SFLVASVLPGPDGNINS(0.987)PT(0.013)R 179.84 2.7929e-13 29630000.0 88942.0 89969.0 111347.0 117332.0 124009.0 99049.0 87846.0 92525.0 84619.0 101688.0 True False 83998.95970303597 96869.33300406935 104183.05524544702 101351.17919101065 108429.88076547405 112692.1006727002 91931.0130635466 92794.23243166157 101545.16445240566 98752.0032228464 0.8506051215334001 0.9809353718675604 1.054996879509824 1.0263202353708096 1.098001835170759 1.141162680197952 0.9309280831103004 0.9396693677419347 1.0282846032323631 1.0 16.59152239365418 -4.800860036413884 2.9153871509208935 1.028202578318306 0.8242569988401763 0.4364995431886143 0.060465990208139 0.39632456860613774 4.932561093211409 0.017156501859188104 0.18929976538269958 1.581757722957379e-05 4.800860036413884 -0.20394557947812963 SFLVIVDGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SFLVIVDGSPK 11 0 Q9H116;Q9H116-4 Q9H116 GZF1 GDNF-inducible zinc finger protein 1 1 SFLVIVDGS(1)PK 133.88 0.0017364999999999998 3160700.0 46229.0 41031.0 35226.0 40993.0 34063.0 28218.0 37618.0 30224.0 22602.0 33513.0 True False 43659.77724934962 44177.9457645407 32959.597511168875 35409.682683130675 29783.70141291632 32104.77336249995 39367.31153865285 30311.946836147432 27123.031552645047 32545.392612768956 1.3415040884226426 1.3574254976788265 1.0127269903709015 1.0880090802542026 0.9151434050063018 0.9864613939210513 1.209612432919533 0.9313744405177264 0.8333908235601839 1.0 14.990165697896037 -5.267881074647718 7.496286913960942 1.0018382164718205 1.3504759123434196 0.6834892184246817 0.0958762895141483 0.06989037259457352 32.42461951781823 0.025992865051300565 0.05963057117913137 5.396583800372076e-06 5.267881074647718 0.3486376958715991 SFNYS(ph)PNSSTSEVSSTSASK ddPTM_A459_Selumetinib_30min_R2 1 SFNYSPNSSTSEVSSTSASK 20 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.469)FNY(0.001)S(0.525)PNS(0.005)STSEVSSTSASK 104.5 0.00090674 0.0 28948.0 26018.0 31787.0 32745.0 35118.0 23187.0 21571.0 25263.0 22665.0 31775.0 True False 27339.186048025553 28013.496938944223 29741.859027068796 28285.074511724302 30706.162881096647 26380.798779370823 22574.094242125608 25336.51114748522 27198.63331301214 30857.573188635255 0.8859797846349915 0.9078321476447637 0.9638431008574138 0.9166331499504181 0.9950932529070571 0.854921371104024 0.7315576667072307 0.8210791883276348 0.8814248984113018 1.0 14.913336984348817 -6.919189192980924 8.20678410183197 0.8365243887621532 0.9328204418237959 0.20728684936629482 0.06922868245515469 0.316982443831112 28.378096618426735 0.0238729428829614 0.02105028133116193 1.2045111013520925e-07 6.919189192980924 0.09629605306164268 SFPIKPVPS(ph)PSWSGSCR ddPTM_A459_Selumetinib_30min_R1 2 SFPIKPVPSPSWSGSCR 17 1 Q9P0U3;Q9P0U3-2 Q9P0U3 SENP1 Sentrin-specific protease 1 1 S(0.001)FPIKPVPS(0.723)PS(0.252)WS(0.013)GS(0.013)CR;S(0.004)FPIKPVPS(0.863)PS(0.091)WS(0.031)GS(0.011)CR 93.738 0.015085 43225600.0 3677.57 3950.48 4708.45 5079.490000000001 4472.219999999999 4022.56 4392.26 4343.32 2490.99 3875.29 True False 3763.2502256944535 3487.9559650716747 4069.0683516645336 4192.452425336356 4067.70849063457 3982.0966985922523 4060.9482919711845 4228.121044508328 4227.028095288711 4372.721220021196 0.8606197459979421 0.7976625514339941 0.9305574599710725 0.9587742310533196 0.9302464726106762 0.9106678652093328 0.9287004790923991 0.9669313070198042 0.9666813598668476 1.0 12.094315657935205 -1.5959076354330808 0.2537119237892881 0.9824468680051806 6.2153606179776036e-15 0.6485263203876355 0.03295445136244926 32.054053778254676 0.4532869800558869 0.04429711933702096 13.4075495945392 0.025356678520846422 1.5959076354330808 -0.9824468680051743 SFPIKPVPS(ph)PSWSGSCR ddPTM_A459_Selumetinib_30min_R2 1 SFPIKPVPSPSWSGSCR 17 1 Q9P0U3;Q9P0U3-2 Q9P0U3 SENP1 Sentrin-specific protease 1 1 S(0.001)FPIKPVPS(0.861)PS(0.103)WS(0.003)GS(0.032)CR 85.988 0.0062824 21239000.0 103570.0 88145.0 90928.0 111750.0 98083.0 66990.0 62654.0 80958.0 83322.0 93333.0 True False 97813.99402355978 94905.4380691538 85077.79147492097 96529.45722049766 85760.9366668547 76217.26442532672 65567.53514654569 81193.5743766816 99988.72821119793 90638.23378174327 1.079169241747315 1.047079517212195 0.9386523537052605 1.064997112067965 0.9461894069269587 0.8408952960056324 0.723398199753453 0.8957982849952218 1.1031628049148734 1.0 16.46783212796354 -6.476500460652836 5.041113481448871 0.893899021122478 1.0256957878142556 0.23308177638832217 0.09972814530492367 0.2954359482815836 17.326804148689398 0.03360442929775229 0.0371872316507437 3.338101510959272e-07 6.476500460652836 0.13179676669177764 SFPIKPVPSPS(ph)WSGSCR ddPTM_A459_Selumetinib_30min_R2 1 SFPIKPVPSPSWSGSCR 17 1 Q9P0U3;Q9P0U3-2 Q9P0U3 SENP1 Sentrin-specific protease 1 1 SFPIKPVPS(0.168)PS(0.637)WS(0.168)GS(0.027)CR 65.416 0.023918 17803000.0 84973.0 74574.0 90926.0 87797.0 97198.0 68102.0 78055.0 74731.0 70252.0 88418.0 True False 80250.54083387024 80293.58600679635 85075.92015274354 75838.89714172739 84987.11827885512 77482.4323315958 81684.71216304829 74948.45483761693 84304.36300488531 85865.1426024469 0.9346113964478916 0.9351127078254946 0.9908085816224933 0.8832326464868202 0.9897743799523283 0.902373535793648 0.9513139987578676 0.8728624045338873 0.9818228963435378 1.0 16.389784960265175 -8.505421672860823 24.07200021738447 1.0000000245832121 0.9339865616720305 0.28655278271733564 0.03735562503432141 467.2930871676542 644362.2946824847 0.03330705338215886 0.00859984420177858 3.1230456120218436e-09 8.505421672860823 -0.0660134629111816 SFPSS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 SFPSSPSK 8 0 A0A0G2JIS2;A2ABF8;A0A0G2JIR1;Q96KQ7-2;A2ABF9;A0A0G2JK64;Q96KQ7-3;Q96KQ7 A0A0G2JIS2 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 SFPS(0.04)S(0.562)PS(0.397)K;SFPS(0.013)S(0.987)PSK 166.34 0.00025385 27538000.0 214329.0 196404.0 194213.0 202625.0 203850.0 176053.0 198652.0 203940.0 163851.0 189346.0 True False 202417.45220696638 211467.5552616031 181717.5470231262 175027.1254523789 178240.54055787795 200302.7026999859 207889.71162147028 204533.43163591553 196625.7783794552 183879.08900001008 1.100818224126373 1.1500359089857766 0.9882447645970023 0.9518598683745345 0.9693355646213158 1.0893174628463322 1.1305783205259348 1.1123256741602865 1.0693210383451728 1.0 17.48839789811648 -6.934380354725028 24.999561510595218 1.0906361137408782 1.031483568182927 0.11259222152651227 0.06455145898274453 119.40226650860546 45488.21789627965 0.02516034435196875 0.022189334480029622 1.163106935184534e-07 6.934380354725028 -0.05915254555795113 SFQSLACS(ph)PGLPAADR ddPTM_A459_Selumetinib_30min_R2 1 SFQSLACSPGLPAADR 16 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;C9J0X3;C9K0F0;A0A087WXJ0 Q96JY6;A0A087WXJ0 PDLIM2 PDZ and LIM domain protein 2 1 SFQS(0.003)LACS(0.997)PGLPAADR 102.69 0.0048052 2787300.0 8334.5 11851.0 13176.0 11827.0 14625.0 10646.0 7773.4 10347.0 8480.3 8876.4 True False 7871.301855646982 12759.933593028978 12328.270504944108 10216.142197287018 12787.676750841121 12112.389865234047 8134.878502699881 10377.108056961939 10176.596959379522 8620.115268343101 0.9131318562007987 1.4802509242410171 1.4301746694987947 1.1851514601904731 1.4834693449869703 1.4051308466507555 0.9437087845651873 1.2038247440926106 1.1805639069297036 1.0 13.073491445850602 -7.2487843654073245 24.963453843960757 1.0990097479823975 1.3304988080103304 0.29546251794569867 0.17555926046109893 974.6012065609781 1922514.954500565 0.06617965664031102 0.05091449696168247 5.639175809911897e-08 7.2487843654073245 0.2314890600279329 SFS(ph)ADNFIGIQR ddPTM_A459_Selumetinib_30min_R1 1 SFSADNFIGIQR 12 0 Q8N7R7-3;Q8N7R7-2;Q8N7R7 Q8N7R7-3 CCNYL1 Cyclin-Y-like protein 1 1 SFS(1)ADNFIGIQR 115.24 0.0053048 11140000.0 3906.1 3421.6 4537.7 3539.1 4352.5 3589.8 3561.1 4700.1 2292.0 3528.5 True False 3997.1045300524856 3020.9974813413132 3921.505263801917 2921.0626221348784 3958.81714349629 3553.689871277612 3292.4833599419426 4575.438079923557 3889.3565989432846 3981.4173455005407 1.0039401005196487 0.7587743808760434 0.984952071963435 0.7336740584194257 0.9943235787552411 0.8925690433568061 0.8269626301957084 1.1491983087616595 0.9768773935087978 1.0 11.959066392144019 -7.751416292087348 24.992508579120607 1.0472784023387824 0.8826877143147132 0.34985345184625616 0.09796146621288424 194.54141160237563 485090.7627453032 0.04307963103919008 0.02450357216256422 1.772489650006942e-08 7.751416292087348 -0.1645906880240693 SFS(ph)DHIR ddPTM_A459_Selumetinib_30min_R2 3 SFSDHIR 7 0 Q96QB1-6 Q96QB1-6 DLC1 Rho GTPase-activating protein 7 1 SFS(1)DHIR;SFS(1)DHIR;SFS(1)DHIR 109.48 0.010468 11618900.0 77667.0 72414.0 86365.0 93342.0 96031.0 62063.0 64241.0 62182.0 54600.3 74254.0 True False 73350.57906563487 77967.920952291 80808.36992710219 80628.65857606861 83966.72725196743 70611.61489817977 67228.33379112661 62362.93932521573 65521.88565984807 72110.09408493861 1.0172026537537877 1.0812344920872303 1.120624940967597 1.1181327607352165 1.164424042396379 0.9792195641154792 0.9323012907449301 0.8648295376200495 0.9086368072501712 1.0 16.137913603883533 -6.945374857243809 4.442285388547371 0.9192240810634211 1.100953359474672 0.7547781956549565 0.04713163494047116 0.10182024384233691 4.204828340436774 0.01803270271642265 0.015552677343429704 1.1340315643172032e-07 6.945374857243809 0.18172927841125097 SFS(ph)ENGDR ddPTM_A459_Selumetinib_30min_R1 1 SFSENGDR 8 0 P47974 P47974 ZFP36L2 Zinc finger protein 36, C3H1 type-like 2 1 S(0.002)FS(0.998)ENGDR 98.943 0.019052 6033900.0 1710.0 2236.0 1909.3 2298.9 2016.4 1857.9 2622.8 2764.9 1427.7 2342.6 True False 1749.8396729192161 1974.208080511802 1650.0275470341824 1897.4402706975989 1834.0169760243355 1839.2112128382294 2424.9600843716066 2691.5658703390664 2422.702624917681 2643.295528856331 0.6619916894711789 0.7468737638148157 0.6242312026866311 0.7178313018667876 0.6938372785043281 0.6958023394508585 0.917400289864981 1.0182614244059272 0.9165462576808074 1.0 11.368122016558138 -7.321834498117891 3.489629705378376 0.9746674654318261 0.6893961051851314 0.9215083204057886 0.03928704016102221 0.058941123133268464 1.4374871932247812 0.016420343570795897 0.010850029776732523 4.766125807570168e-08 7.321834498117891 -0.28527136024669475 SFS(ph)ENGDR ddPTM_A459_Selumetinib_30min_R2 2 SFSENGDR 8 0 P47974 P47974 ZFP36L2 Zinc finger protein 36, C3H1 type-like 2 1 S(0.03)FS(0.97)ENGDR;S(0.003)FS(0.997)ENGDR 98.754 0.019204 44875000.0 106394.0 86333.0 88592.0 145525.0 126818.0 94607.0 75664.0 119478.0 96438.0 138368.0 True False 100481.04740892744 92954.46349565186 82892.08717167648 125704.24395537244 110885.98907269529 107638.25549316166 79182.52592537165 119825.66119935244 115728.29470285744 134372.956316761 0.7477773070055909 0.6917646678586709 0.6168807284128863 0.9354876710388542 0.8252106086830504 0.8010410609663383 0.5892742713698472 0.8917394130771684 0.8612469195814074 1.0 17.035883287303783 -14.522878745052928 0.11741408990311719 1.781824212288866 0.6507336045381362 0.35778629426442066 0.10243420229195302 188.23505218822967 1.437106578554286 34.60656012797164 1.1119039338606571 3.000000001570888e-15 14.522878745052928 -1.1310906077507297 SFS(ph)EPFGR ddPTM_A459_Selumetinib_30min_R2 1 SFSEPFGR 8 0 A0A494C127;A0A494C1S3;A0A494C175;A0A0S2Z4A4;A0A494C1P6;P58340-2;P58340-5;P58340-4;P58340;P58340-3 A0A494C127 MLF1 Myeloid leukemia factor 1 1 S(0.002)FS(0.998)EPFGR 83.647 0.038396 1586400.0 7113.8 6519.8 10701.0 8353.9 11810.0 6048.4 5706.7 7382.3 7004.0 7696.9 True False 6718.443474797711 7019.847695538799 10012.509310367863 7216.084408718698 10326.322217260413 6881.512198091457 5972.072857611522 7403.781270794449 8404.995708111051 7474.6704980521345 0.8988280455370584 0.9391514578961225 1.3395251754545003 0.9654050182679192 1.3815086858947703 0.9206442210241573 0.7989747319521063 0.9905160732802658 1.124463708507466 1.0 12.867794267811792 SFS(ph)KEVEER ddPTM_A459_Selumetinib_30min_R1 1 SFSKEVEER 9 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 S(0.004)FS(0.996)KEVEER 148.78 0.0071001000000000015 484370000.0 2716.9 3129.0 3872.6 3802.1 2534.5 3139.5 2760.1 2544.9 1730.0 2378.3 True False 2780.198483832876 2762.6552253673644 3346.7221906691298 3138.134609256311 2305.2549225023185 3107.919480437924 2551.9034348307414 2477.4009849997783 2935.6836457992495 2683.57797160378 1.0360043618078116 1.0294670975094962 1.2471119624927598 1.1693845464757915 0.8590228966310357 1.1581252765242165 0.9509332174558184 0.9231708604014272 1.0939438603473124 1.0 11.3899420910186 -6.226751925661546 24.96800680107991 0.9993908126691606 1.1230345042049934 0.2743097430024616 0.09791359721920721 850.4538602392211 612156.1899246426 0.029108019123171503 0.037576365341503735 5.932641075520593e-07 6.226751925661546 0.12364369153583277 SFS(ph)KEVEER ddPTM_A459_Selumetinib_30min_R2 1 SFSKEVEER 9 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 SFS(1)KEVEER 139.76 0.011165 66081000.0 82843.0 70188.0 66433.0 50745.0 75077.0 48364.0 49508.0 49892.0 36835.0 62641.0 True False 78238.91770680452 75571.19391000915 62158.773106781424 43833.443459992355 65645.1560631042 55025.70199532026 51810.22009824088 50037.1774599348 44203.029255892434 60832.39156913612 1.286139105970967 1.2422854331499094 1.0218038696725884 0.7205609105500245 1.0791151616733392 0.9045460909223576 0.8516880359595673 0.82254167836008 0.7266363875511226 1.0 15.892552103093724 -5.38054460241908 3.0452283684258 0.8733119490563355 1.272801875581424 0.684455261999958 0.10521753195434483 0.14328493669459744 2.497503448232475 0.028815304774377066 0.07131396928049255 4.163469596363718e-06 5.38054460241908 0.39948992652508863 SFS(ph)LDPLMER ddPTM_A459_Selumetinib_30min_R1 3 SFSLDPLMER 10 0 Q63HR2-6;Q63HR2;Q63HR2-4;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(0.001)FS(0.999)LDPLMER;S(0.001)FS(0.999)LDPLMER;S(0.001)FS(0.999)LDPLMER 158.05 0.00048193 13410900.0 8810.7 10299.3 9870.2 11382.7 9546.900000000001 9401.0 9110.5 8289.7 4949.9 6841.7 True False 9015.97216736218 9093.453167985333 8529.881053127729 9394.92512474207 8683.384580642096 9306.43447542505 8423.28765009437 8069.830227259483 8399.618773607923 7719.898838801486 1.167887346145835 1.1779238767067952 1.1049213508155233 1.2169751600269199 1.1248054879939582 1.2055124904810117 1.0911137342574406 1.0453284940340388 1.0880477774384882 1.0 12.914366227269996 -7.468930625415408 4.343434182990676 1.0520123255319318 1.1642491212908128 0.6868139751722051 0.03728830228225768 0.12462810621844853 4.888161268553712 0.01580913808986646 0.009956459766752275 3.396795289651529e-08 7.468930625415408 0.11223679575888101 SFS(ph)LEGLTGGAGVGNKPSSSLEVSSANAEELR ddPTM_A459_Selumetinib_30min_R2 1 SFSLEGLTGGAGVGNKPSSSLEVSSANAEELR 32 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(0.066)FS(0.829)LEGLT(0.104)GGAGVGNKPS(0.001)SSLEVSSANAEELR 84.42299999999999 1.9596e-07 14422000.0 24654.0 17975.0 19646.0 21227.0 27962.0 19297.0 24373.0 29586.0 24861.0 22827.0 True False 23283.829377781592 19353.62470126537 18381.997748947488 18335.84598138255 24449.163576548344 21954.986589274984 25506.39279418328 29672.09036177403 29833.89467437875 22167.925198331304 1.050338683907788 0.8730462832273639 0.8292159768894924 0.8271340604651077 1.1029071669002546 0.9903942923322229 1.1505990103261121 1.338514547315759 1.3458135755810157 1.0 14.436186127375203 -7.056030499133515 1.3016372899845479 1.2525609114372827 0.9030858952144204 0.5387106403139026 0.12138950898675792 0.31369410211265875 1.073748946639322 0.06859339552419369 0.04745021678642021 8.789607880158252e-08 7.056030499133515 -0.34947501622286226 SFS(ph)MQDLR ddPTM_A459_Selumetinib_30min_R1 4 SFSMQDLR 8 0 E5RGS2;Q9H6H4 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 S(0.003)FS(0.997)MQDLR;SFS(1)MQDLR;S(0.002)FS(0.998)MQDLR;S(0.002)FS(0.998)MQDLR 133.42 0.0030655 102623000.0 21254.3 32689.300000000003 28916.800000000003 31778.300000000003 30320.199999999997 26379.0 27563.5 24512.3 12843.5 21935.0 True False 21749.483836331514 28862.021559156718 24990.057388612604 26228.816457570803 27577.743263466095 26113.651210215667 25484.363003498853 23862.154176828182 21794.481447874376 24750.570914993445 0.878746753399376 1.166115386117119 1.0096759979574483 1.0597257149200492 1.1142265509019027 1.0550726809455733 1.0296474813056087 0.9641052022106256 0.8805647967769372 1.0 14.595174183397463 -7.76356938976364 2.955291581633187 0.935521558659281 1.053732757868258 0.2596848784939133 0.07499829962984973 0.30624218611819437 5.42472511333566 0.04279981919293255 0.01966216732659595 1.7235766831214218e-08 7.76356938976364 0.11821119920897705 SFS(ph)MQDLR ddPTM_A459_Selumetinib_30min_R2 4 SFSMQDLR 8 0 E5RGS2;Q9H6H4 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 S(0.001)FS(0.999)MQDLR;S(0.002)FS(0.998)MQDLR;SFS(1)MQDLR;S(0.004)FS(0.996)MQDLR 126.03 0.004940600000000001 85966900.0 219194.0 150937.0 223678.0 221674.0 218152.0 165853.0 178755.0 206471.0 162625.0 179013.0 True False 207012.07498310477 162513.38256105114 209286.80100219278 191481.61879102036 190745.79545637552 188697.7452863671 187067.46169631268 207071.7964268857 195154.5441221531 173844.42955836895 1.1907892332759482 0.9348207645991132 1.2038740702469497 1.1014538646849747 1.0972212106015848 1.0854402741907303 1.0760624437120894 1.1911327671121066 1.1225815208340006 1.0 17.407437314425735 SFS(ph)PLQPGQAPTGR ddPTM_A459_Selumetinib_30min_R1 1 SFSPLQPGQAPTGR 14 0 Q7Z3C6;H7C152;Q7Z3C6-2;H7C1G6 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 S(0.124)FS(0.876)PLQPGQAPTGR 182.7 7.6255e-05 14265000.0 1279.3 1293.4 1634.7 1612.3 1533.6 1323.1 1388.8 1430.0 805.43 1266.0 True False 1309.1052009155271 1141.9681267146527 1412.7167187643508 1330.742071619356 1394.8861507790707 1309.7908152786806 1284.0416978707053 1392.0717547053657 1366.7558837202835 1428.5034318842804 0.9164172599772756 0.7994157390355928 0.9889487748033577 0.9315637904096797 0.9764667830998022 0.9168972128761281 0.8988719727309149 0.9744966120726366 0.9567746588592032 1.0 10.48028878691921 -1.5228787452803376 0.232858453713096 0.9754595727863268 0.3772637331849029 0.26544161004895117 0.047913269223712966 69.8297851278907 0.9196574678960653 0.06885547410476821 15.984373234461177 0.029999999999999995 1.5228787452803376 -0.5981958396014239 SFS(ph)PLQPGQAPTGR ddPTM_A459_Selumetinib_30min_R2 1 SFSPLQPGQAPTGR 14 0 Q7Z3C6;H7C152;Q7Z3C6-2;H7C1G6 Q7Z3C6 ATG9A Autophagy-related protein 9A 1 S(0.137)FS(0.863)PLQPGQAPTGR 222.88 4.353e-09 14215000.0 46065.0 33270.0 39713.0 53130.0 39519.0 34103.0 33566.0 35202.0 33548.0 33251.0 True False 43504.89171280559 35821.70202008897 37157.90881624508 45893.60234563785 34554.269915657445 38800.37869378891 35126.885509767206 35304.431991995174 40258.53740943883 32290.957233526697 1.3472778585713716 1.1093415955751353 1.150721811915355 1.4212524581955703 1.0700912229316268 1.2015865126941385 1.0878242244641807 1.093322558903261 1.2467433875772393 1.0 14.97884258840449 SFS(ph)PTMK ddPTM_A459_Selumetinib_30min_R1 2 SFSPTMK 7 0 A3KN83-3;A3KN83-2;A3KN83;A3KN83-4 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 1 S(0.013)FS(0.494)PT(0.494)MK;S(0.375)FS(0.621)PT(0.005)MK 93.143 0.026096 62100000.0 10967.9 13172.9 14219.099999999999 15191.0 13388.900000000001 11770.9 13394.5 12431.0 6901.3 9950.1 True False 11223.43073018167 11630.610744084936 12288.224319925484 12538.177020386798 12177.876359002283 11652.49543312208 12384.142081026186 12101.289498421245 11711.00204899096 11227.292257181502 0.9996560589221892 1.035923041608314 1.0944958088238383 1.1167587636606497 1.084667262599559 1.0378722817755632 1.1030390763280176 1.0778457727134247 1.0430833882942752 1.0 13.454722407184029 -5.000279367252164 3.664233414209207 1.0746189139648399 1.0028794331778734 0.29882335444772345 0.03326691280635241 0.2457505747609095 7.051240223650632 0.008376607900627813 0.0358552982789353 9.993569399814744e-06 5.000279367252164 -0.07173948078696646 SFS(ph)SPENFQR ddPTM_A459_Selumetinib_30min_R2 1 SFSSPENFQR 10 0 G3V1T9;J3KPD3;Q9Y580;I3L521;F5GXV8;F5GY08 G3V1T9 RBM7 RNA-binding protein 7 1 S(0.002)FS(0.641)S(0.357)PENFQR 152.64 0.00062605 12295000.0 50726.0 58779.0 49415.0 63978.0 66698.0 49678.0 51903.0 50730.0 42338.0 56329.0 True False 47906.85199226698 63287.160295726135 46235.69269898398 55264.08603179408 58318.80095231455 56520.69356801591 54316.59234384335 50877.61590119639 50806.783022559386 54702.635409681636 0.8757686285766793 1.1569307369151935 0.8452187422546168 1.010263685065767 1.0661058743431748 1.0332352937791458 0.9929428799371893 0.9300761383827539 0.9287812669728754 1.0 15.739322718982093 -7.66335870536894 5.922956673729511 0.947418975791628 1.0026573745018919 0.05038616831193299 0.0855255997623942 0.5657528941428364 28.368692492021594 0.039506928692328476 0.022336434351321873 2.1709073780140065e-08 7.66335870536894 0.055238398710263814 SFS(ph)SQRPVDR ddPTM_A459_Selumetinib_30min_R2 1 SFSSQRPVDR 10 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8 E7EPN9 PRRC2C Protein PRRC2C 1 SFS(0.918)S(0.082)QRPVDR 132.17 0.011798 79817000.0 61967.0 52354.0 57877.0 67935.0 63333.0 47081.0 57180.0 57943.0 44915.0 57088.0 True False 58523.12221355529 56369.38345535727 54153.25683171297 58682.13580558839 55376.54233579629 53565.980391234654 59838.98330002052 58111.604537019935 53899.25502995544 55439.72110756284 1.0556171828500023 1.016768885723482 0.9767952606876593 1.058485407813194 0.9988604060319141 0.9662021980108306 1.079352170331491 1.0481943879961657 0.9722136755591064 1.0 15.758632379489438 -8.272177044449721 24.839631040446246 0.9861068363450001 1.023243067878345 0.16107230738502354 0.035347468516359774 1454.1173979119428 3363802.18814202 0.03329220661200281 0.00896976340437378 5.343464833506249e-09 8.272177044449721 0.037136231533345 SFS(ph)SSAEEHS ddPTM_A459_Selumetinib_30min_R1 2 SFSSSAEEHS 10 0 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 SFS(0.963)S(0.018)S(0.018)AEEHS;S(0.004)FS(0.935)S(0.007)S(0.055)AEEHS 161.27 0.00042827 22014000.0 3992.4 5157.6 4968.1 4952.2 5775.1 5110.9 6639.5 7675.1 3897.6 3744.1000000000004 True False 4085.415152141915 4553.7457942968085 4293.459307819892 4087.3912343071224 5252.743224676715 5059.4889863259095 6138.677169507884 7471.5314157616385 6613.942530559051 4224.691705622378 0.9670327296793967 1.077888307976772 1.0162775433071236 0.967500475565464 1.243343559883001 1.1975995738558987 1.4530473694301296 1.7685388512061706 1.5655444210892284 1.0 12.04463035008107 -6.9247277349430565 1.5113455571377727 1.5115030923503108 1.0229462291857843 0.47547705406245544 0.19341106068725242 0.2995731268378631 1.4040910711229087 0.09112280112521155 0.07209513817643484 1.1892475490840516e-07 6.9247277349430565 -0.4885568631645265 SFS(ph)SSAEEHS ddPTM_A459_Selumetinib_30min_R2 2 SFSSSAEEHS 10 0 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 SFS(0.931)S(0.022)S(0.048)AEEHS;S(0.009)FS(0.989)S(0.001)SAEEHS 192.26 0.00017576 27033000.0 93684.0 90035.0 116446.0 130874.0 129603.0 98908.0 112370.0 121096.0 151132.0 272714.0 True False 88477.4183267662 96940.39499184598 108953.99113681883 113048.73542975748 113321.11247447936 112531.67920257094 117595.4276569308 121448.36931147813 181362.6229809025 264840.03822393273 0.33407871000212985 0.3660337600082924 0.41139546674092353 0.42685666483015045 0.4278851235426189 0.4249043307697341 0.4440243569119984 0.4585725410928567 0.6848006222818667 1.0 18.01476171810998 -8.57509870664031 1.3151121602571303 1.00119365401896 0.4012865729325089 0.9750599203474364 0.02990037759089914 0.07703254804728217 0.2896790007009906 0.03130504155154945 0.009499380455168106 2.6601203977568713e-09 8.57509870664031 -0.5999070810864512 down SFS(ph)TTSASSQK ddPTM_A459_Selumetinib_30min_R1 1 SFSTTSASSQK 11 0 B5MCH3;Q8N3C7;Q8N3C7-3;Q8N3C7-2 B5MCH3 CLIP4 CAP-Gly domain-containing linker protein 4 1 S(0.388)FS(0.607)T(0.005)TSASSQK 120.55 0.0046978 3333700.0 1424.6 1402.8 1607.7 1742.5 1440.6 1290.3 1192.1 1647.2 653.01 996.5 True False 1457.7904082109444 1238.5595238559727 1389.383170463967 1438.2050857760505 1310.2979843585883 1277.3207534986643 1102.1789372347844 1603.5109051403344 1108.1102760366293 1124.4104817319783 1.2964930796139917 1.101519012832543 1.2356547657967754 1.2790747766427086 1.165319966014795 1.1359915033263934 0.980228266404143 1.4260903212769567 0.9855033317812539 1.0 10.134953092329926 -6.528785310823936 4.25433456718479 1.1256347919453211 1.2203611374357812 0.15393151671398886 0.1306419767231689 0.49939754827565996 21.792140875075848 0.04193746117555485 0.04413236045787907 2.959475092206974e-07 6.528785310823936 0.0947263454904601 SFS(ph)TTSASSQK ddPTM_A459_Selumetinib_30min_R2 1 SFSTTSASSQK 11 0 B5MCH3;Q8N3C7;Q8N3C7-3;Q8N3C7-2 B5MCH3 CLIP4 CAP-Gly domain-containing linker protein 4 1 S(0.024)FS(0.957)T(0.019)TSASSQK 88.552 0.033706 0.0 10688.0 8288.3 8059.5 11247.0 9603.3 5548.8 6348.4 7850.7 5636.5 5796.8 True False 10094.00374745395 8923.985958915036 7540.960544520118 9715.139197842827 8396.847599408724 6313.096833008707 6643.613179115949 7873.544237246652 6763.95749696858 5629.431322104822 1.7930769859147764 1.5852375574551627 1.3395599152101534 1.7257763070480758 1.4915978398097192 1.1214448621514161 1.1801570707557594 1.3986393627949554 1.2015347749974081 1.0 12.458773475135057 -6.6361652027566045 4.858310169240949 1.206621993615546 1.5916552093347056 0.664636133133422 0.14531454612825292 0.14512372331351978 5.572494512418486 0.04938157314735459 0.049197476111400594 2.311185463233909e-07 6.6361652027566045 0.3850332157191596 SFSEDAVT(ph)DSSGSGTLPR ddPTM_A459_Selumetinib_30min_R1 1 SFSEDAVTDSSGSGTLPR 18 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 SFSEDAVT(0.536)DS(0.214)S(0.214)GS(0.031)GT(0.005)LPR 342.97 6.523199999999995e-163 22912000.0 2061.7 2591.3 1980.9 1886.8 2263.8 1861.0 2445.1 2049.9 1073.3 1812.5 True False 2109.7335986301428 2287.9093913373135 1711.9046603048282 1557.3057996225264 2059.0396897063524 1842.280029652804 2260.6641384386958 1995.5299929863831 1821.3117092695577 2045.1520302450701 1.031577881463088 1.1186989316697173 0.8370549646129197 0.7614621194864983 1.0067905266972343 0.9008034622404301 1.1053770599967578 0.9757367488945353 0.8905507670504624 1.0 10.997992377280529 SFSEDAVT(ph)DSSGSGTLPR ddPTM_A459_Selumetinib_30min_R2 2 SFSEDAVTDSSGSGTLPR 18 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 SFSEDAVT(0.735)DS(0.187)S(0.078)GSGTLPR;SFSEDAVT(0.784)DS(0.04)S(0.04)GS(0.129)GT(0.006)LPR 284.15 5.2819999999999986e-67 36510000.0 68244.0 40656.0 64385.0 64897.0 74108.0 56047.0 45843.0 53903.0 34501.0 53441.0 True False 64451.27168237713 43774.18447035576 60242.539197087615 56057.916646430655 64797.8905060741 63766.96550599028 47974.790336181184 54059.84880587797 41402.16403848363 51898.019473606786 1.2418830686815403 0.8434654137932474 1.1607868625453908 1.0801552200838689 1.2485619136011088 1.228697475409819 0.9244050316906448 1.0416553339452694 0.7977600004473981 1.0 15.663391863216901 -7.279519034442342 24.242911976703866 0.9444263409760745 1.1247099683916597 0.36171076884815623 0.12518833853381256 698.7586345523242 936957.1210123453 0.052714253634915074 0.035632107923943834 5.2538898763456496e-08 7.279519034442342 0.18028362741558523 SFSEDAVTDS(ph)SGSGTLPR ddPTM_A459_Selumetinib_30min_R1 2 SFSEDAVTDSSGSGTLPR 18 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 SFSEDAVT(0.037)DS(0.622)S(0.05)GS(0.279)GT(0.012)LPR;SFSEDAVT(0.094)DS(0.401)S(0.401)GS(0.102)GT(0.002)LPR 103.39 0.0020685 27652200.0 2757.83 3094.39 2763.5299999999997 2696.13 3104.9 2589.65 3059.52 2822.43 1767.68 2944.94 True False 2822.0820731969598 2732.0973802571175 2388.257804983697 2225.3015081281983 2824.0623432146167 2563.600472214072 2828.737943166318 2747.5699878552896 2999.623853760935 3322.951735144782 0.8492696548522095 0.8221899076539188 0.7187157669864982 0.6696761450347221 0.8498655918911718 0.7714829093364413 0.8512726541431601 0.8268461918347957 0.9026985923496239 1.0 11.698249623141036 -8.411154888331188 0.7115884565381558 1.0003945690310332 0.7738471664164362 0.6149851334741637 0.05439252995292265 0.49539438098951394 0.5761165884448648 0.05645235718411992 0.022708443378947396 3.880119593437333e-09 8.411154888331188 -0.22654740261459694 SFSEDAVTDSSGS(ph)GTLPR ddPTM_A459_Selumetinib_30min_R2 1 SFSEDAVTDSSGSGTLPR 18 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 SFSEDAVT(0.038)DS(0.066)S(0.005)GS(0.832)GT(0.059)LPR 319.8 5.502899999999996e-127 16160000.0 23336.0 15213.0 25767.0 23395.0 27862.0 19067.0 19116.0 21826.0 14249.0 17271.0 True False 22039.078541409555 16379.788182495135 24109.179272988375 20208.560641373966 24361.72647055966 21693.306177007096 20004.931877635405 21889.51004651119 17099.198150324737 16772.341354552933 1.314013236167945 0.976595207326183 1.437436715801388 1.2048741564568894 1.4524940767406067 1.2933976073124904 1.1927334088156374 1.3050956681470818 1.0194878454273217 1.0 14.033796477206826 -8.268076880997096 23.026229306289462 1.009743718184375 1.269581717413276 0.4052059007683735 0.12710568378292245 189.66873258442723 657953.4867735634 0.1094947515253551 0.03111570578353343 5.394151240798136e-09 8.268076880997096 0.25983799922890105 SFSEDAVTDSSGSGT(ph)LPR ddPTM_A459_Selumetinib_30min_R1 2 SFSEDAVTDSSGSGTLPR 18 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 SFSEDAVTDSSGS(0.007)GT(0.993)LPR;SFSEDAVTDSSGS(0.011)GT(0.989)LPR 359.98 1.0632999999999993e-205 24788000.0 4608.0 5210.200000000001 4051.4 4553.1 4699.9 4931.6 5160.8 4967.8 2695.41 3942.1 True False 4715.357434392832 4600.187361843735 3501.2421327472275 3757.986557272274 4274.794874834738 4881.992581534534 4771.51670101608 4836.037806311405 4573.913905042629 4448.106934305702 1.0600818514559485 1.034189921641749 0.7871308366586584 0.8448507674779747 0.9610368945642229 1.0975438885883162 1.0727072823308503 1.0872125777853525 1.0282832613053094 1.0 12.11897575611787 -6.6357396516904315 5.219874473904847 1.0629726775965673 0.9257828415059736 0.3645601468970451 0.07924112834127876 0.23779898532171456 9.955072024121902 0.029080781833421714 0.028986042301045723 2.3134512287449574e-07 6.6357396516904315 -0.13718983609059376 SFSEDAVTDSSGSGT(ph)LPR ddPTM_A459_Selumetinib_30min_R2 1 SFSEDAVTDSSGSGTLPR 18 0 Q27J81-2;Q27J81;A0A0A0MQU1 Q27J81-2 INF2 Inverted formin-2 1 SFSEDAVT(0.022)DS(0.035)S(0.006)GS(0.198)GT(0.738)LPR 193.27 6.0911e-10 14147000.0 33443.0 19889.0 33612.0 30081.0 37012.0 28522.0 24110.0 26681.0 19996.0 25231.0 True False 31584.37194293624 21414.422346785377 31449.440513978567 25983.91590738064 32362.221668521794 32450.646603062727 25231.162773058662 26758.637292722677 23995.758734921266 24502.51547198917 1.2890256912210878 0.8739683226102216 1.2835188513575677 1.0604591164154138 1.3207714002065503 1.324380210683255 1.0297376529321027 1.0920771511526097 0.9793181749993295 1.0 14.580642246029338 -7.321996127636785 24.798039962869193 1.032956098829317 1.1815950389710352 0.26948663877118284 0.13359056130016503 359.051712307911 147030.39653861808 0.056048497089815734 0.03778789759073697 4.7643523489543224e-08 7.321996127636785 0.1486389401417183 SFSEDT(ph)LMDGPAR ddPTM_A459_Selumetinib_30min_R2 1 SFSEDTLMDGPAR 13 0 Q9BRG2;M0QZQ6 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 SFS(0.136)EDT(0.864)LMDGPAR 133.88 0.006157500000000001 0.0 17936.0 15540.0 19994.0 18823.0 22857.0 17736.0 15536.0 16658.0 15795.0 16820.0 True False 16939.18892349682 16731.868031024416 18707.607807821238 16259.274928513862 19985.499315827394 20178.97300862212 16258.454783999965 16706.47202211965 18954.4413491739 16334.362896391664 1.037027830895 1.0243355150827806 1.145291550486725 0.9954030672421029 1.22352487468258 1.2353694561959163 0.9953528574776267 1.0227807553981911 1.1604028555874086 1.0 13.99562256471164 -5.2380202639225475 23.27154791628585 1.1002431181064067 1.0306816230145428 0.08335217986746735 0.08788010519561251 871.9497190916833 866445.5601790012 0.02298993533131025 0.0607078984559411 5.780690744168215e-06 5.2380202639225475 -0.06956149509186393 SFSKEELMS(ph)SDLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R1 3 SFSKEELMSSDLEETAGSTSIPK 23 1 O00567 O00567 NOP56 Nucleolar protein 56 1 SFSKEELMS(0.556)S(0.393)DLEET(0.037)AGS(0.008)T(0.003)S(0.001)IPK;SFSKEELMS(0.499)S(0.499)DLEET(0.001)AGSTSIPK;SFSKEELMS(0.5)S(0.5)DLEETAGSTSIPK 100.76 2.496e-05 520983000.0 14329.2 18686.7 26940.6 31404.9 20856.1 20690.2 16692.0 15416.899999999998 8769.4 12030.400000000001 True False 14663.042480230413 16498.85247678886 23282.214494123014 25920.623757984686 18969.669437443525 20482.07537319852 15432.9090011937 15007.993730851154 14881.031308365273 13574.619026019476 1.0801807735542837 1.2154191911510952 1.7151283914116684 1.9094918029228451 1.397436598484492 1.508850843912379 1.1368944477640441 1.1055922602383332 1.0962393331143732 1.0 13.728624088666743 -7.3122941152882595 4.122633563296161 1.083798274437488 1.4884670870298518 0.4235877677503037 0.2207726022347877 0.25207340043543053 9.110363511380779 0.10694787007187459 0.07177619933046671 4.871984351618805e-08 7.3122941152882595 0.40466881259236365 SFSKEELMSS(ph)DLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R1 2 SFSKEELMSSDLEETAGSTSIPK 23 1 O00567 O00567 NOP56 Nucleolar protein 56 1 SFSKEELMS(0.058)S(0.942)DLEETAGSTSIPK;SFSKEELMS(0.404)S(0.595)DLEETAGSTSIPK 96.287 5.9369e-05 290203000.0 4182.799999999999 7610.799999999999 8894.1 11242.6 7132.400000000001 6170.9 5385.2 5013.8 2675.05 3665.6600000000003 True False 4280.251101688005 6719.723997835072 7686.330071794227 9279.290959739365 6487.275679327498 6108.826348728906 4978.990028350604 4880.817736882347 4539.3644720781995 4136.183167552079 1.0348311301264712 1.6246195406795807 1.8583147216720661 2.243442948207522 1.5684207919560944 1.4769235551877888 1.203764395012836 1.1800293988844228 1.0974766561812435 1.0 12.014084360321654 -7.124987685239746 1.818491752456053 1.1083020149517837 1.7070943462195194 0.4561675942998601 0.28271036197892857 0.352524217791666 2.301437817860161 0.14993077565753754 0.10416189644219995 7.499154734716966e-08 7.124987685239746 0.5987923312677357 SFSKEELMSS(ph)DLEETAGSTSIPK ddPTM_A459_Selumetinib_30min_R2 1 SFSKEELMSSDLEETAGSTSIPK 23 1 O00567 O00567 NOP56 Nucleolar protein 56 1 SFSKEELMS(0.164)S(0.836)DLEETAGSTSIPK 105.72 1.1599e-05 15254000.0 50298.0 57780.0 53757.0 43051.0 54326.0 35742.0 31357.0 24639.0 19896.0 48380.0 True False 47502.63851884719 62211.54020801744 50298.33314619612 37187.37953288268 47501.08219939789 40665.13606642828 32815.16263271673 24710.695410793982 23875.755940687817 46983.14369366402 1.0110570469394373 1.3241246821124715 1.0705612522258525 0.7915047101860415 1.011023921879534 0.8655260774283232 0.698445443469592 0.5259481053867066 0.508177062317514 1.0 15.51985562843642 -6.405954026430487 0.7669231222761944 0.6448164896626197 1.169253608012822 0.4976252139575086 0.17171124809021554 0.5349169562823237 0.6942197325249286 0.10498980135103514 0.1532721708395186 3.926865022291471e-07 6.405954026430487 0.5244371183502022 SFSKEELMSS(ph)DLEETAGSTSIPKR ddPTM_A459_Selumetinib_30min_R1 1 SFSKEELMSSDLEETAGSTSIPKR 24 2 O00567 O00567 NOP56 Nucleolar protein 56 1 S(0.005)FS(0.005)KEELMS(0.202)S(0.787)DLEET(0.001)AGSTSIPKR 63.125 0.0017392 34294000.0 1100.0 765.57 3687.9 4165.8 2079.7 1539.9 1451.7 1230.6 645.92 629.51 True False 1125.6278597725943 675.9367084961627 3187.1034361846537 3438.3212317508605 1891.5915022008578 1524.410004117332 1342.1971002296252 1197.9604904478483 1096.0790638697397 710.3137404466609 1.5846910958878182 0.9516030311776299 4.486895374120925 4.84056697198166 2.6630366195807835 2.1461080045540855 1.8895834668573668 1.686523042190546 1.5430914558692066 1.0 9.472312583138113 -6.980764896829899 2.1545395195988326 1.569318729998679 2.991973855661034 0.2571208706604031 1.1079979349016063 0.5280804497086832 4.937952615743411 0.5389501654125015 0.4279272134457929 1.0452859264527056e-07 6.980764896829899 1.4226551256623547 SFSKEELMSSDLEET(ph)AGSTSIPK ddPTM_A459_Selumetinib_30min_R1 1 SFSKEELMSSDLEETAGSTSIPK 23 1 O00567 O00567 NOP56 Nucleolar protein 56 1 S(0.003)FS(0.002)KEELMS(0.232)S(0.232)DLEET(0.256)AGS(0.114)T(0.123)S(0.037)IPK 56.247 0.028122 16569000.0 3812.9 4367.2 5695.1 6361.0 4330.7 4285.3 3817.8 3501.9 1969.8 2547.0 True False 3901.733151388112 3855.8861937438023 4921.736700945038 5250.170760758374 3938.988949647183 4242.193772741087 3529.820272271588 3409.0182362256774 3342.606731500207 2873.9322598809326 1.357628781253794 1.341676088741059 1.712544435946081 1.8268248121394097 1.3705921342106984 1.47609386343603 1.2282197188662438 1.186186008561981 1.16307777262596 1.0 11.488810341765063 -7.378474733942909 1.2202162980330529 1.092486246237584 1.5452638564526655 0.606635675871734 0.14996279593922768 0.36742074542480063 1.0463058584946976 0.11535275627346056 0.059833233778306176 4.1833602558160614e-08 7.378474733942909 0.45277761021508156 SFSLASSSNS(ph)PISQR ddPTM_A459_Selumetinib_30min_R1 4 SFSLASSSNSPISQR 15 0 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 S(0.001)FSLAS(0.01)S(0.078)S(0.098)NS(0.518)PIS(0.294)QR;SFSLASSSNS(1)PISQR;SFSLASSSNS(1)PISQR;SFSLASS(0.002)SNS(0.998)PISQR 296.51 2.1169e-68 178593000.0 11155.0 12972.4 14733.9 15883.099999999999 15194.1 12104.5 13402.2 11779.7 6454.18 10625.8 True False 11414.889796148445 11453.585377294858 12733.117307519466 13109.414747712823 13819.796337736227 11982.739720006648 12391.261263826877 11467.26409014181 10952.2720653437 11989.724934056852 0.9520560195442361 0.9552834147813443 1.0620024543975153 1.0933874479868582 1.152636646273765 0.9994173999746764 1.0334900368422515 0.956424284394466 0.9134715037735134 1.0 13.549510940651533 -10.216547920734389 6.215573625035164 0.9999999998643915 1.0178573326045428 0.0 0.07022762613339796 1.642892037435467e-10 3.0433097194108477e-18 0.07509340976837538 0.01821282680289012 6.073682412015321e-11 10.216547920734389 0.017857332740151333 SFSLASSSNS(ph)PISQR ddPTM_A459_Selumetinib_30min_R2 4 SFSLASSSNSPISQR 15 0 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 SFSLAS(0.162)S(0.101)S(0.019)NS(0.718)PISQR;SFSLASSSNS(0.975)PIS(0.024)QR;SFSLASS(0.001)SNS(0.999)PISQR;SFSLASSSNS(0.998)PIS(0.002)QR 276.14 5.365399999999998e-46 238611000.0 427256.0 339856.0 448108.0 455827.0 466722.0 357748.0 333753.0 360466.0 288101.0 363537.0 True False 403510.82196128205 365921.86239072325 419277.2191431008 393742.5762545652 408088.20981238055 407024.53968699527 349273.1758190229 361514.8963816417 345729.2502145206 353040.7422274403 1.142958230303423 1.0364862142596123 1.1876170905877736 1.1152893396108472 1.1559238382449266 1.1529109561660078 0.9893282390450272 1.0240033320254638 0.9792899483306394 1.0 18.429475159966458 -7.264567932067931 24.964281227237954 1.000155650849583 1.1304033421927953 0.743932559162863 0.03841762042754602 140.35995218785598 1119991.9959674524 0.015507708553675116 0.010944720462973848 5.4379106561334975e-08 7.264567932067931 0.13024769134321224 SFSLEGLT(ph)GGAGVGNKPSSSLEVSSANAEELR ddPTM_A459_Selumetinib_30min_R1 1 SFSLEGLTGGAGVGNKPSSSLEVSSANAEELR 32 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 SFSLEGLT(0.899)GGAGVGNKPS(0.096)S(0.002)S(0.003)LEVSSANAEELR 125.42 1.4731e-18 46774000.0 1180.2 1902.2 918.1 1001.5 1051.6 1227.6 1656.7 1485.2 715.54 1235.9 True False 1207.6963637305607 1679.489539691211 793.4270627623123 826.6068254833372 956.4829656750588 1215.2514585716183 1531.733785183178 1445.8076713904954 1214.2191190261237 1394.5398036854517 0.8660178508629828 1.2043324509294764 0.5689526112237635 0.5927452363129423 0.6858771353440696 0.8714354766783887 1.0983793945035873 1.0367632874798944 0.8706952041219753 1.0 10.44557339777344 -7.0287509273997415 6.618433819832426 1.0027345696501444 0.7835863435890295 0.2578659145317552 0.17425567626672417 0.3017290492414112 46.75046882381192 0.07221576234210718 0.0576749234418914 9.359422933205926e-08 7.0287509273997415 -0.21914822606111495 SFSLEGLT(ph)GGAGVGNKPSSSLEVSSANAEELR ddPTM_A459_Selumetinib_30min_R2 1 SFSLEGLTGGAGVGNKPSSSLEVSSANAEELR 32 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(0.051)FS(0.304)LEGLT(0.52)GGAGVGNKPS(0.026)S(0.026)S(0.07)LEVS(0.003)S(0.001)ANAEELR 49.087 0.01845 12170000.0 9694.8 7613.0 9284.5 8234.5 11961.0 10656.0 13668.0 14602.0 10618.0 11669.0 True False 9156.00182735933 8196.89262034678 8687.145378199268 7112.946894695183 10458.352247303286 12123.767274463084 14303.589082628188 14644.489402508765 12741.89669170805 11332.085650296925 0.807971463498374 0.7233348629104303 0.766597221930779 0.6276820626138497 0.9228973880045863 1.069861952035759 1.2622203470773627 1.292303098867334 1.124408788012839 1.0 13.468125790613154 -6.68667403110257 2.251487143378134 1.1897126048068989 0.7345338401852173 0.8247872304750867 0.09082421185371879 0.11061502687186567 1.1486735656140235 0.033546314188846044 0.03246397355809236 2.0574342673446976e-07 6.68667403110257 -0.4551787646216816 SFSLEGLT(ph)GGAGVGNKPSSSLEVSSANAEELRHPFSGEER ddPTM_A459_Selumetinib_30min_R1 1 SFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEER 40 2 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(0.025)FS(0.09)LEGLT(0.373)GGAGVGNKPS(0.13)S(0.13)S(0.13)LEVS(0.061)S(0.061)ANAEELRHPFSGEER 50.35 0.0041948 41976000.0 1319.6 1108.8 1622.2 1619.7 1469.6 1075.8 1287.7 1210.3 610.63 971.27 True False 1350.3441125053773 978.9811805328642 1401.9141501067663 1336.8498005345593 1336.6749394789529 1064.9784287482462 1190.5677522667818 1178.1989123915407 1036.1945113493612 1095.9419654709675 1.232131038914167 0.8932783043052459 1.279186484572941 1.2198180584863951 1.2196585052790943 0.9717471018555119 1.0863419686234481 1.075055933171812 0.9454830127835002 1.0 10.097955688486062 -6.7624762164857035 24.997390073895946 1.0248301453727147 1.1624722011556057 0.3380256607725366 0.10655300686222972 38.241116724482 921947.797676353 0.03718579758779832 0.034675344778534345 1.7279206050100457e-07 6.7624762164857035 0.13764205578289102 SFSLEGLTGGAGVGNKPS(ph)SSLEVSSANAEELR ddPTM_A459_Selumetinib_30min_R1 1 SFSLEGLTGGAGVGNKPSSSLEVSSANAEELR 32 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 S(0.001)FS(0.013)LEGLT(0.054)GGAGVGNKPS(0.492)S(0.178)S(0.26)LEVS(0.001)SANAEELR 95.674 6.461899999999999e-09 46671000.0 1134.4 1321.3 897.15 972.86 1094.2 865.34 1566.5 1083.7 687.71 1295.8 True False 1160.8293128418472 1166.6015817442944 775.3219576921994 802.9682638439538 995.2298031967008 856.6354652658559 1448.3376438036144 1054.9567556462962 1166.993641648903 1462.1285521608604 0.7939310884301336 0.7978789416431198 0.5302693504934032 0.549177610037953 0.6806718887514124 0.5858824547266009 0.9905679234997055 0.721521205565126 0.7981470848949762 1.0 10.513854445071264 -7.249042611512922 24.99701653476887 0.8543524926564091 0.6532468970816102 0.46520601239068793 0.11511973088200336 791.7544760182129 1596506.9056236371 0.04608702541194172 0.03544599234677521 5.63582356309064e-08 7.249042611512922 -0.2011055955747989 SFSPT(ph)MK ddPTM_A459_Selumetinib_30min_R1 1 SFSPTMK 7 0 A3KN83-3;A3KN83-2;A3KN83;A3KN83-4 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 1 S(0.009)FS(0.065)PT(0.926)MK 113.26 0.033243 54313000.0 4182.5 4997.3 5462.2 5420.1 5015.3 4088.1 4359.1 4406.7 2434.7 4118.8 True False 4279.944112271706 4412.213792818258 4720.463241716912 4473.581282877919 4561.667000523132 4046.9774256978108 4030.289577468458 4289.820001021069 4131.508076547648 4647.488100509455 0.9209155612044583 0.9493760279525179 1.0157020609045686 0.9625804705960469 0.9815338741853012 0.8707881199855431 0.8671973957344098 0.9230405561556623 0.8889765798635944 1.0 12.18223545591594 -6.7516655061548745 24.999891583215526 0.9025153675995755 0.9676657043689735 0.30257586082854193 0.041722397475118224 220.03354188242892 562807.5179509803 0.013573257577469282 0.013410538305453627 1.7714728223525912e-07 6.7516655061548745 0.06515033676939797 SFSS(ph)PENFQR ddPTM_A459_Selumetinib_30min_R1 1 SFSSPENFQR 10 0 G3V1T9;J3KPD3;Q9Y580;I3L521;F5GXV8;F5GY08 G3V1T9 RBM7 RNA-binding protein 7 1 SFS(0.035)S(0.965)PENFQR 152.64 0.00062605 13774000.0 2701.8 3080.3 3288.6 3391.1 3518.1 2724.6 2893.4 2731.5 1464.2 2445.6 True False 2764.746683212359 2719.6570440073806 2842.0261829867545 2798.9080438307983 3199.8884761710033 2697.192997738866 2675.1485085102972 2659.051746837554 2484.640459063156 2759.516582161293 1.001895296112687 0.9855556083947522 1.029900019937854 1.0142747689664735 1.1595829852433082 0.9774150353633264 0.9694265023821971 0.9635933206659503 0.900389754903067 1.0 11.430199839490477 -6.98060019706241 24.999204098430077 0.9579044944657975 1.0370177245480956 0.37375393796378 0.04971637307616054 271.94219411576125 350432.2733637322 0.018111204798258902 0.015970662148625334 1.0456824108765331e-07 6.98060019706241 0.07911323008229809 SFSS(ph)PENFQR ddPTM_A459_Selumetinib_30min_R2 3 SFSSPENFQR 10 0 G3V1T9;J3KPD3;Q9Y580;I3L521;F5GXV8;F5GY08 G3V1T9 RBM7 RNA-binding protein 7 1 S(0.002)FS(0.436)S(0.561)PENFQR;SFS(0.028)S(0.972)PENFQR;SFS(0.046)S(0.954)PENFQR 190.26 0.00018055 30745500.0 105799.0 109844.0 125851.0 135371.0 133136.0 98779.0 102305.0 102922.0 92999.0 112740.0 True False 99919.11512695374 118268.68159587157 117753.8836762082 116933.2362719999 116410.26542905858 112384.91062351623 107062.38521351176 103221.48598034558 111601.39860916918 109484.9032663019 0.9126291584139126 1.0802282147357316 1.0755262156079504 1.0680306853592525 1.0632540373709058 1.0264877373107832 0.9778734968884449 0.9427919548805581 1.0193313898055816 1.0 16.74037242659771 -7.142961645459025 3.7683490656458565 0.9802663834289996 1.0456237369922168 0.21366837445959552 0.04895702433366653 0.3312920838649881 8.368347708494001 0.019674575640938656 0.014911427777863653 7.195125186540525e-08 7.142961645459025 0.06535735356321715 SFSS(ph)QRPVDR ddPTM_A459_Selumetinib_30min_R1 1 SFSSQRPVDR 10 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3;H7C5N8 E7EPN9 PRRC2C Protein PRRC2C 1 SFS(0.127)S(0.873)QRPVDR 123.67 0.01937 96986000.0 7071.0 8485.9 8006.0 8134.4 8039.3 7104.5 8307.3 6669.0 4204.0 6384.8 True False 7235.740542229107 7492.366883012121 6918.82917381012 6713.879741599262 7312.146734453695 7033.0351803698795 7680.673672754399 6492.11645603502 7133.88095198846 7204.351273218601 1.0043569875787695 1.039978007577752 0.960368104138692 0.9319200975884374 1.0149625493187446 0.9762204692203765 1.0661159320904403 0.9011382440732398 0.9902183668511408 1.0 12.81465281123878 -5.260743330793566 24.999860713651163 0.9790424492529282 1.0221674982429765 0.13093039455990796 0.04326299858574593 120.68836922042223 4334486.580677717 0.011058557289537946 0.025960521676202837 5.486010938523016e-06 5.260743330793566 0.04312504899004832 SFT(ph)FGAYGGVDK ddPTM_A459_Selumetinib_30min_R1 1 SFTFGAYGGVDK 12 0 P47736-4 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 S(0.05)FT(0.95)FGAYGGVDK 152.0 0.0011866 12392000.0 1568.7 1331.5 1646.4 1542.8 867.65 1406.6 965.21 1075.2 1101.4 805.28 True False 1605.2476578411545 1175.6073610024432 1422.8279230278506 1273.3789419427792 789.1712106960489 1392.450881090615 892.4034326049706 1046.6822032581879 1868.9953569267582 908.6455320914481 1.766637925513509 1.2938019496959652 1.5658778619126628 1.4014034042646055 0.8685138294573432 1.5324467373823785 0.9821249333069489 1.1519147635591382 2.0569025994381476 1.0 9.827573790213046 -1.5229087661142076 0.8728294837150009 1.288623193279135 184.32417936466138 0.13569331408897634 0.33345062905907064 1615.933431500743 4.045670271748547 0.11063903607646582 588199.2493412448 0.02999792630593697 1.5229087661142076 183.03555617138224 SFT(ph)PDHVVYAR ddPTM_A459_Selumetinib_30min_R1 3 SFTPDHVVYAR 11 0 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 S(0.127)FT(0.873)PDHVVYAR;S(0.074)FT(0.926)PDHVVYAR;S(0.017)FT(0.983)PDHVVYAR 118.37 0.0072257000000000016 31987800.0 22314.1 23636.3 23288.8 23860.5 24880.0 21067.6 23486.5 21238.8 11507.599999999999 18556.9 True False 22833.97511431968 20868.951007782252 20126.308876221472 19693.711592057076 22629.60839292077 20855.679071850303 21714.89439591036 20675.47803065475 19527.55671814997 20938.858874512967 1.0905071403921383 0.9966613334972229 0.9611941604286497 0.940534138468668 1.0807469752072212 0.9960274911273264 1.037061977734708 0.9874214327802359 0.9325988983057308 1.0 14.353895199996764 SFT(ph)PDHVVYAR ddPTM_A459_Selumetinib_30min_R2 1 SFTPDHVVYAR 11 0 Q6NZI2;Q6NZI2-3;Q6NZI2-2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 S(0.006)FT(0.994)PDHVVYAR 111.5 0.012117 0.0 16487.0 15745.0 11266.0 18172.0 18288.0 13150.0 14746.0 13619.0 13531.0 15491.0 True False 15570.718542690243 16952.590871845514 10541.157825493345 15696.942251551505 15990.497943205626 14961.293136185215 15431.718218644664 13658.629035253174 16237.578087728542 15043.73457954835 1.0350301290118689 1.1268871291369507 0.7007008645196275 1.0434205794145808 1.0629340645868866 0.9945198818200892 1.025790380509888 0.9079280788310239 1.0793581874146594 1.0 13.87687513742775 SFTQS(ph)SPTFPLASVGTTFAQR ddPTM_A459_Selumetinib_30min_R1 1 SFTQSSPTFPLASVGTTFAQR 21 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 SFTQS(0.966)S(0.007)PT(0.001)FPLASVGT(0.013)T(0.013)FAQR 138.28 5.2605e-05 0.0 813.17 901.34 822.18 977.0 898.67 728.51 822.76 774.55 361.57 494.12 True False 832.1152788466187 795.8106937784019 710.5324719114665 806.3852905613782 817.3854571730748 721.181850834156 760.6985507921238 754.006417907021 613.5578819720427 557.545115136383 1.4924626837472557 1.4273476211583989 1.2743945783430652 1.4463139729313665 1.46604361688853 1.293495057629095 1.364371295058422 1.3523684405746808 1.1004632007617146 1.0 9.122944738754043 -8.32862278605892 2.190588811847018 0.9974693878217026 1.393361604195026 0.8121479403785472 0.06643005421405593 0.1256976804333562 1.1496883434551572 0.06464337402645418 0.018363485428716894 4.69220754960514e-09 8.32862278605892 0.3958922163733235 SFVT(ph)PPQSHFVR ddPTM_A459_Selumetinib_30min_R2 1 SFVTPPQSHFVR 12 0 H0YNU5;A0A3B3IT82;P54132;H0YLV8 H0YNU5 BLM Bloom syndrome protein 1 S(0.001)FVT(0.999)PPQSHFVR 89.624 0.034602999999999995 3674800.0 42042.0 37048.0 47014.0 43731.0 44280.0 33767.0 39496.0 37687.0 31707.0 49169.0 True False 39705.47394746063 39889.462471904284 43989.17042497283 37774.762359817236 38717.1505317774 38418.09774369322 41332.64225983927 37796.66293058127 38049.28596760095 47749.36321359578 0.8315393394849547 0.8353925536863802 0.9212514568665011 0.7911050497331353 0.8108411908779839 0.8045782217416955 0.8656166172299976 0.7915637065463387 0.796854311907705 1.0 15.543193873017977 -10.607707769100767 4.781766569524712 1.0000072162344917 0.8284287100255021 0.645446604630775 0.03832018690647686 64069239326.87536 12260717069.938889 5276966.793562243 0.009536159782016869 2.4676992602504068e-11 10.607707769100767 -0.17157850620898962 SFYPEEVS(ph)SMVLTK ddPTM_A459_Selumetinib_30min_R2 1 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 SFYPEEVS(0.911)S(0.089)MVLTK 162.46 0.00027546 3709900.0 15104.0 15573.0 18390.0 16591.0 13651.0 8722.8 13910.0 13276.0 13806.0 12566.0 True False 14264.580146102586 16767.3990249127 17206.807421518068 14331.277178928634 11936.039338511591 9924.286522305425 14556.842562142092 13314.630962039892 16567.585771870527 12203.186929611036 1.1689225305145148 1.374018043124997 1.4100257187543153 1.174388072688929 0.9781083750793647 0.8132536672223009 1.1928722100306364 1.0910781780890315 1.3576441848702059 1.0 13.574970344315238 -5.970611336050249 5.579633334721352 1.0699196717163555 1.3211483554304533 0.363147657318011 0.14546437254718464 0.19858649532896044 17.48370056991251 0.04369150210818881 0.06421431735041426 1.0700120386804099e-06 5.970611336050249 0.2512286837140978 SFYPEEVSSMVLT(ph)K ddPTM_A459_Selumetinib_30min_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 SFYPEEVS(0.114)S(0.114)MVLT(0.772)K;SFYPEEVS(0.005)S(0.012)MVLT(0.982)K 168.93 1.993e-05 15112000.0 4529.2 5796.5 6135.4 6253.799999999999 5782.7 5277.2 5524.599999999999 4884.75 2769.28 4368.4 True False 4634.721547710939 5117.843085280258 5302.246379339816 5161.69122836515 5259.655806018605 5224.116159314228 5107.874974119025 4755.190562095826 4699.265899791295 4929.126691819343 0.9402723519772751 1.0382859693531754 1.0756969156706244 1.0471816918262182 1.067056323536546 1.0598461930354652 1.0362636818802695 0.9647125869147994 0.9533668322200891 1.0 12.267116347292356 -7.741713944878636 6.960585540655156 0.9690953608915006 1.0418005270988688 0.38987709344447463 0.03702223393128138 0.14916731539985245 29.728732636270912 0.018795390773344064 0.010289443618815577 1.812533554224084e-08 7.741713944878636 0.07270516620736822 SFYPEEVSSMVLTK ddPTM_A459_Selumetinib_30min_R1 1 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 197.56 0.0014360999999999998 11124000.0 1943.3 2246.3 2281.9 2610.7 2278.4 2134.6 2053.2 1826.6 1652.5 1888.3 False True 1988.5751089964394 1983.3021517234606 1972.0305135794777 2154.7902539084857 2072.3191222841906 2113.127862061728 1898.3254709591972 1778.1526343670064 2804.1718061752945 2130.6816985995947 0.9333046368697137 0.9308298621173682 0.9255397063182212 1.0113149492600122 0.9726084959786516 0.991761398922512 0.8909474710403177 0.8345463499009306 1.3160913748958165 1.0 11.057099370438324 -8.252871893858778 24.999865245972927 1.1580456967269015 0.9398520172219117 0.5194950348896387 0.08522997254240298 423.6097099814855 1236098.9156698277 0.05672736455671191 0.02066621375880804 5.586349539438462e-09 8.252871893858778 -0.2181936795049898 SFYPEEVSSMVLTK ddPTM_A459_Selumetinib_30min_R2 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ; 172.76 0.0016174 4750700.0 23494.8 20012.7 25575.2 25124.6 26160.5 20320.9 18962.3 20775.1 19808.8 23086.8 False True 22189.05307313634 21547.609739027183 23929.71947617233 21702.58613764752 22873.984112162678 23119.919520236213 19844.084523084624 20835.552101497047 23771.11350411625 22420.22409728983 0.9896891742406164 0.9610791420069646 1.0673273992415164 0.9679914903379998 1.0202388706242993 1.0312082261047053 0.8850975100415428 0.9293195291484915 1.0602531625448701 1.0 14.452513077961877 SGAHS(ph)SASPPR ddPTM_A459_Selumetinib_30min_R2 1 SGAHSSASPPR 11 0 P18615;P18615-3;A0A0A0MT02;P18615-4;A0A0G2JI50;E9PD43;A0A0A0MSN9 P18615 NELFE Negative elongation factor E 1 S(0.055)GAHS(0.867)S(0.067)AS(0.011)PPR 92.906 0.016106 6350800.0 0.0 400.97 681.18 826.9 793.01 1001.4 1079.4 959.66 954.56 2001.9 True False 0.0 431.7231096782406 637.3536204127073 714.2747935179364 693.3849942006503 1139.3337601958842 1129.594238790524 962.452451719735 1145.4986726348495 1944.0999454391476 0.0 0.22206837189161063 0.327839945630335 0.3674064161123109 0.35666118700704114 0.5860469071401178 0.5810371228292808 0.49506325741001406 0.5892179953619081 1.0 10.924886673915944 -7.630210938537358 0.22387914389779964 1.085866294212006 1.9552840079970953e-15 0.8814993548469707 0.08738778097346556 0.9191722539821663 0.19470110867020204 0.3113985595261147 0.3972692879971997 2.34309049063438e-08 7.630210938537358 -1.085866294212004 down SGAHSSAS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 3 SGAHSSASPPR 11 0 P18615;P18615-3;A0A0A0MT02;P18615-4;A0A0G2JI50;E9PD43;A0A0A0MSN9 P18615 NELFE Negative elongation factor E 1 SGAHS(0.004)S(0.004)AS(0.992)PPR;SGAHS(0.003)S(0.021)AS(0.976)PPR;S(0.006)GAHS(0.291)S(0.162)AS(0.541)PPR 130.1 0.002459 12789990.0 874.81 1037.03 758.467 1083.5500000000002 1018.04 1149.6100000000001 733.33 815.13 752.9359999999999 666.3699999999999 True False 895.1913709160582 915.6140454978326 655.4713473610093 894.3283332525914 925.95846174956 1138.0459671623648 678.0143276926299 793.5101044846039 1277.677399730348 751.9050804934657 1.1905643333711158 1.2177255736813573 0.8717474643619003 1.1894165320250998 1.2314831828797663 1.5135500433319053 0.9017286161275274 1.0553328140352947 1.6992535798425843 1.0 9.55440673925137 -5.985651563493484 24.928512155431427 1.2316162166724227 1.0932501534117989 0.06495730862370552 0.2378543175438668 715.8732512018098 1243724.6660502478 0.06697075871404759 0.09929006953735582 1.0335903275766387e-06 5.985651563493484 -0.13836606326062384 SGAHSSAS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 SGAHSSASPPR 11 0 P18615;P18615-3;A0A0A0MT02;P18615-4;A0A0G2JI50;E9PD43;A0A0A0MSN9 P18615 NELFE Negative elongation factor E 1 SGAHSSAS(1)PPR;SGAHSS(0.002)AS(0.998)PPR 145.14 0.00070712 62105000.0 23644.3 18494.3 40030.0 74105.0 79013.0 48438.0 44068.2 64798.0 77362.0 104264.0 True False 22330.244461632243 19912.753341452702 37454.5133813686 64011.771161744604 69086.68055481778 55109.894823615134 46117.458619481695 64986.551452113636 92836.56167488376 101253.62740959453 0.22053772326892743 0.1966621231346209 0.3699078673977413 0.632192374726508 0.682313140993419 0.5442757581482267 0.4554647551828027 0.6418194894808843 0.9168714647559068 1.0 16.62761406788683 -6.5751012135493205 0.22918465575716232 1.0514791491785125 2.2933697931338317e-15 0.7729692770512012 0.12073060528590913 2.67024584583067 0.2875176936955353 0.31164610798188197 0.8675873715842048 2.660105042598502e-07 6.5751012135493205 -1.0514791491785103 down SGAMS(ph)PMSWNSDASTSEAS ddPTM_A459_Selumetinib_30min_R1 2 SGAMSPMSWNSDASTSEAS 19 0 Q13158 Q13158 FADD FAS-associated death domain protein 1 S(0.034)GAMS(0.943)PMS(0.023)WNSDASTSEAS;S(0.029)GAMS(0.969)PMS(0.002)WNSDASTSEAS 130.87 0.00027886 15352900.0 2644.13 3494.7 3304.8 3500.6000000000004 3602.7000000000003 2523.95 3151.6000000000004 2999.4 1918.73 2509.21 True False 2705.7330844186454 3085.538899358047 2856.0263119669835 2889.2859244003703 3276.8364211083485 2498.5613545632445 2913.872274632284 2919.8461685757147 3255.944671505429 2831.29154527516 0.9556532914930482 1.089799072266921 1.0087362132427162 1.0204833653468117 1.1573645344213 0.8824811272907683 1.0291671585340387 1.0312771121887232 1.1499856582904462 1.0 11.46724459952434 -8.03175811437369 24.6782392433224 1.0802057040718582 1.0232272330123544 0.07175449379623089 0.07639065873193662 1485.6334862049066 1154430.6048020988 0.04922834688199328 0.018653703998419143 9.29483930089804e-09 8.03175811437369 -0.05697847105950382 SGAMS(ph)PMSWNSDASTSEAS ddPTM_A459_Selumetinib_30min_R2 1 SGAMSPMSWNSDASTSEAS 19 0 Q13158 Q13158 FADD FAS-associated death domain protein 1 S(0.014)GAMS(0.93)PMS(0.041)WNS(0.009)DAS(0.001)T(0.001)S(0.001)EAS(0.003) 66.779 0.02184 3864400.0 50638.0 48151.0 64307.0 59595.0 46314.0 46604.0 47979.0 53742.0 44332.0 56160.0 True False 47823.74267997503 51844.026870132315 60169.55763216765 51478.058192890836 40495.621267586714 53023.277971009535 50210.11856858487 53898.38032253297 53199.638739574424 54538.514878796384 0.8768801788287797 0.9505947674840035 1.1032489198850648 0.9438844880043589 0.7425141912569881 0.9722171219521794 0.9206359703811018 0.9882627064985906 0.9754508141228743 1.0 15.734987794761055 -10.369789501947956 6.478090587581997 1.0000000019517425 0.9424242835501817 0.039456928330101504 0.08645680069969919 2.5884173413599033e-09 4.0423448355643684e-10 0.08786790135929612 0.0213110957416876 4.267863276056623e-11 10.369789501947956 -0.05757571840156084 SGAQAS(ph)STPLSPTR ddPTM_A459_Selumetinib_30min_R1 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.002)GAQAS(0.418)S(0.418)T(0.126)PLS(0.035)PT(0.001)R 94.454 0.013188 13456000.0 2505.4 5389.0 3110.6 3960.2 3078.1 2605.7 2990.0 2774.0 1570.3 2505.9 True False 2563.7709453402344 4758.053374721869 2688.1976053027424 3268.625412160871 2799.686398482695 2579.489023786305 2764.461892737188 2700.4245087781 2664.684409825759 2827.556674533031 0.9067089506751052 1.6827437687018802 0.9507139607543662 1.155989353493925 0.990143336011138 0.9122678413554012 0.9776857587456622 0.955038154707924 0.942398231598958 1.0 11.46534022602955 SGAQAS(ph)STPLSPTR ddPTM_A459_Selumetinib_30min_R2 2 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.206)GAQAS(0.37)S(0.197)T(0.197)PLS(0.028)PT(0.002)R;S(0.009)GAQAS(0.465)S(0.26)T(0.26)PLS(0.006)PTR 113.11 0.0034008000000000003 83994000.0 61850.0 50191.0 56403.0 62125.0 67049.0 54712.0 44977.0 48947.0 47214.0 57246.0 True False 58412.62460516717 54040.48831049846 52774.09238694309 53663.467828397406 58625.7051943348 62248.081373913745 47068.51962023475 49089.42766638792 56658.11926938253 55593.15923702955 1.0507160486439784 0.9720708276370651 0.9492911198288453 0.9652890493162185 1.0545489049178793 1.1197075724462782 0.8466602773832523 0.8830120169477684 1.0191563143193998 1.0 15.762619749153103 -7.272584998022069 24.962837586455695 0.9274581638355229 1.0125486609286931 0.2547903937651137 0.06689684785842369 1065.9221905489746 2387336.49687249 0.029220613323564338 0.01990426777108488 5.3384478182240724e-08 7.272584998022069 0.08509049709317018 SGAQASS(ph)TPLSPTR ddPTM_A459_Selumetinib_30min_R1 3 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 SGAQAS(0.127)S(0.406)T(0.406)PLS(0.061)PT(0.001)R;SGAQAS(0.241)S(0.44)T(0.241)PLS(0.039)PT(0.039)R;S(0.002)GAQAS(0.116)S(0.407)T(0.407)PLS(0.033)PT(0.033)R 128.82 0.0011033 32761900.0 6912.8 8368.8 8932.4 8866.9 7775.3 7366.900000000001 7801.999999999999 7302.1 4639.9 6188.4 True False 7073.8547900327185 7388.9770054504315 7719.429142161069 7318.462367327208 7072.025487840714 7292.795674610017 7213.488858573759 7108.424587436395 7873.571415112102 6982.741420120597 1.0130483665984797 1.0581770913296713 1.1055012176045536 1.0480786738342107 1.0127863918120823 1.0444029408845081 1.033045393573972 1.0179991152119203 1.1275759678605026 1.0 12.76957783352388 -5.992255660194352 24.910037148475357 1.0392609935025692 1.0618280780948874 0.04791673412184061 0.038547553343674164 553.4349516947647 1780136.5804759203 0.01072370675499806 0.015864814408275037 1.0179919407938747e-06 5.992255660194352 0.022567084592318265 SGAQASS(ph)TPLSPTR ddPTM_A459_Selumetinib_30min_R2 4 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.001)GAQAS(0.147)S(0.676)T(0.174)PLS(0.002)PTR;S(0.004)GAQAS(0.169)S(0.654)T(0.169)PLS(0.003)PTR;SGAQAS(0.173)S(0.63)T(0.173)PLS(0.023)PT(0.001)R;SGAQAS(0.168)S(0.66)T(0.168)PLS(0.003)PT(0.001)R 150.01 0.00042914 110791000.0 226230.0 246457.0 253237.0 255637.0 267534.0 195636.0 175414.0 184822.0 171404.0 226591.0 True False 213657.04227044398 265359.4594158424 236944.00712359886 220818.7996015773 233923.98713569425 222583.08319321164 183571.09857624705 185359.801421071 205689.58942790815 220048.72907587863 0.9709533118765225 1.2059122564817877 1.0767797120150342 1.0034995454367435 1.0630553883136997 1.011517240422048 0.8342293061503976 0.842357973161272 0.9347456369856194 1.0 17.747463513693823 -7.068577737271582 4.038699868093023 0.8904932952935986 1.0676128301854575 0.5212832854373861 0.07240933314372747 0.17179086976979324 5.4245416526948596 0.028408880565414088 0.02220652905329441 8.53929983103604e-08 7.068577737271582 0.17711953489185894 SGAQASST(ph)PLSPT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 2 SGAQAS(0.038)S(0.172)T(0.789)PLS(0.396)PT(0.604)R 134.08 0.0055306 30368000.0 227140.0 240930.0 246950.0 273220.0 242860.0 205380.0 224660.0 208800.0 199740.0 249830.0 True False 214516.46811346256 259408.55628794743 231061.50585882983 236006.96466921075 212349.75560405274 233669.23074598596 235107.13515534473 209407.57343129907 239693.58120189927 242616.7587637055 0.884178278559846 1.0692112021024738 0.9523724042652395 0.9727562344490296 0.8752476815126731 0.9631207338548533 0.9690473830141524 0.8631208103610426 0.9879514606628916 1.0 17.88831968256312 -6.04177883452898 24.982581852821948 0.9372162269084391 0.9759688796126625 0.03652582146437655 0.05933532021740892 1215.6629015396052 726930.6853914929 0.016586027894078797 0.021414505532852728 9.082829576224164e-07 6.04177883452898 0.038752652704223456 SGAQASST(ph)PLSPTR ddPTM_A459_Selumetinib_30min_R2 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 SGAQAS(0.259)S(0.259)T(0.481)PLS(0.001)PTR 102.39 0.021566 0.0 36548.0 34123.0 34379.0 38029.0 36304.0 29546.0 29483.0 31024.0 23686.0 32804.0 True False 34516.80847323606 36740.124377261665 32167.09256902499 32849.3845963159 31743.1669581221 33615.69330811622 30854.01791945619 31114.27470370032 28423.861842135673 31856.86328497218 1.0834967700513896 1.1532875678501926 1.0097382244220872 1.0311556509021376 0.9964310256840725 1.0552103955562295 0.9685202728044772 0.9766898399685772 0.892236677160367 1.0 14.959316601654482 -5.403654148914047 0.43890441246190753 0.9547524969616339 1.1808818949597115 0.5771355169798212 0.04360341071072542 2.18431221007153 0.489779337121872 0.035219162656032754 0.24432848519036965 3.947715538719782e-06 5.403654148914047 0.22612939799807763 SGAQASSTPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 11 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 SGAQASSTPLS(0.5)PT(0.5)R;SGAQASSTPLS(0.876)PT(0.124)R;SGAQAS(0.006)S(0.019)T(0.061)PLS(0.871)PT(0.043)R;S(0.002)GAQASS(0.001)TPLS(0.921)PT(0.077)R;SGAQAS(0.009)S(0.029)T(0.355)PLS(0.604)PT(0.004)R;SGAQASSTPLS(0.894)PT(0.106)R;SGAQASSTPLS(0.677)PT(0.323)R;SGAQASSTPLS(0.701)PT(0.299)R;SGAQASSTPLS(0.672)PT(0.328)R;SGAQASSTPLS(0.5)PT(0.5)R;SGAQASS(0.002)T(0.002)PLS(0.652)PT(0.344)R 190.18 7.1551e-05 6359003200.0 34259.24 39409.69999999999 42104.4 45405.80000000001 40747.4 35616.3 38101.30000000001 34625.8 20390.850000000002 30119.99 True False 35057.41363512331 34795.59400292752 36386.853742914165 37476.5294024277 37061.80486453775 35258.032359013 35227.288265467374 33707.41130355038 34601.78316124024 33986.18411004754 1.031519558700886 1.023815850883968 1.0706366335536004 1.1026989461681957 1.0904962070625912 1.037422508065254 1.0365179024335631 0.9917974667119295 1.0181132147463035 1.0 15.052660768067662 -7.378571404743563 1.982590255080873 1.0042486271913864 1.0631622766841071 0.5178161895334336 0.02422814738932438 0.3114195451633296 2.3888737911772697 0.015030074480685973 0.008679729605600449 4.182429173805322e-08 7.378571404743563 0.05891364949272071 SGAQASSTPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 SGAQASSTPLS(0.986)PT(0.014)R;SGAQAS(0.002)S(0.001)T(0.003)PLS(0.964)PT(0.03)R 144.18 0.00053187 45954500.0 42588.5 38051.4 46208.6 47667.0 44014.4 35872.1 37330.6 36489.0 26428.7 34902.3 True False 40221.60166527347 40969.82002546475 43235.58898411963 41174.67236983851 38484.91757827154 40813.15616049805 39066.54686918059 36595.17694892086 31715.178479576618 33894.57991193404 1.1866676551170865 1.2087425226072672 1.2755900529363604 1.2147863309360918 1.1354298438943413 1.2041204306570572 1.152589793727626 1.0796763684342334 0.9357005917164335 1.0 15.048766969744339 -7.882562288708101 1.7581186836420215 0.9664221528676668 1.2052467032923566 0.8595248402360895 0.03750710143207207 0.1335974849734241 0.7684615703034859 0.03203674351268952 0.011562483037993813 1.310502070060543e-08 7.882562288708101 0.23882455042468986 SGAQASSTPLSPT(ph)R ddPTM_A459_Selumetinib_30min_R1 2 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 SGAQASSTPLS(0.234)PT(0.765)R;SGAQASSTPLS(0.126)PT(0.874)R 119.0 0.0053243000000000006 13484600.0 1869.18 2794.8 2992.3 3225.5 2744.1 2125.9 2272.8999999999996 2066.0299999999997 1699.8899999999999 2180.7799999999997 True False 1912.7282572088536 2467.583516732731 2585.9620955273567 2662.226975133805 2495.8966395102043 2104.5153761627603 2101.45332307771 2011.2321729887583 2884.5891749466396 2460.70435559605 0.7773092500360689 1.0027956065185306 1.0509032056802963 1.0818963152072532 1.014301711554304 0.8552491774872276 0.8540047967561225 0.8173400304733409 1.172261579651617 1.0 11.264855618469094 -6.732942777175075 24.965788000367553 0.9229944149560964 0.9954007637119371 0.02201183756125713 0.1212904242569639 613.3664946041847 537367.1970631839 0.04058843847429818 0.04058123833451779 1.849512295447865e-07 6.732942777175075 0.07240634875584073 SGAQASSTPLSPT(ph)R ddPTM_A459_Selumetinib_30min_R2 8 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 SGAQASSTPLS(0.188)PT(0.812)R;SGAQASSTPLS(0.294)PT(0.706)R;SGAQASSTPLS(0.038)PT(0.962)R;SGAQASSTPLS(0.217)PT(0.783)R;SGAQASSTPLS(0.234)PT(0.766)R;SGAQASSTPLS(0.09)PT(0.91)R;SGAQASSTPLS(0.028)PT(0.972)R;SGAQASSTPLS(0.04)PT(0.96)R 180.93 0.00017373 6036642100.0 454803.2 392881.7 462924.3 554645.9 482089.7 342964.9 344724.1 368951.19999999995 303125.1 405681.8 True False 429527.0588654607 423014.46307622455 433140.25453186844 479102.1716024548 421525.28194939916 390205.2018496155 360754.45370784495 370024.7869088403 363758.590022949 393968.7123460991 1.0902567777720475 1.073726034123768 1.0994280534423693 1.216091929608782 1.069946086427015 0.9904471843104704 0.9156931563411167 0.9392237893850205 0.9233184733293981 1.0 18.587721534739146 -6.783607661355858 2.7942981418608186 0.9411513789551756 1.1172372512277091 0.7793184550531529 0.042463418064866316 0.1230601904376093 1.9700054350077865 0.01646013468752346 0.015080207014848116 1.6458579085092696e-07 6.783607661355858 0.17608587227253347 SGAVQGAGSLGPGS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 SGAVQGAGSLGPGSPVR 17 0 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 SGAVQGAGSLGPGS(1)PVR;SGAVQGAGSLGPGS(1)PVR 155.94 4.874100000000001e-05 21304600.0 64468.0 82144.0 74750.0 86482.0 100361.0 61808.0 65606.0 55561.0 42133.0 82383.0 True False 60885.12664585156 88444.18066541007 69940.66638164641 74703.00241022889 87752.75394127626 70321.49096283929 68656.80899582274 55722.67331138132 50560.77729438076 80004.38873326006 0.7610223340227823 1.1054916119700486 0.874210371318919 0.9337363061330755 1.0968492520310325 0.8789704174516701 0.8581630343396423 0.6964952072462476 0.6319750465559302 1.0 16.28779152242499 -7.377188009306315 2.40161766499961 0.7525813362101814 0.9558938736010476 0.23325312498445527 0.13131077373504776 0.35864349174515125 4.034958133491338 0.06348485480648229 0.0383247838390726 4.195773065372769e-08 7.377188009306315 0.2033125373908662 SGCNSASST(ph)PDSTR ddPTM_A459_Selumetinib_30min_R2 2 SGCNSASSTPDSTR 14 0 Q92547;A0A2R8YD63 Q92547 TOPBP1 DNA topoisomerase 2-binding protein 1 1 SGCNS(0.007)AS(0.015)S(0.037)T(0.902)PDS(0.02)T(0.02)R;SGCNS(0.001)AS(0.005)S(0.018)T(0.975)PDSTR 148.18 0.001086 694560.0 6136.0 8120.9 7187.6 6572.1 8539.5 8639.9 7951.8 6109.200000000001 7942.4 9509.0 True False 5794.9856843541775 8743.746917190876 6725.157641267171 5676.968642495137 7466.691665901386 9829.967799796706 8321.574456192777 6126.976760567494 9531.10192919778 9234.450462650908 0.6275398528360969 0.9468616408258725 0.728268310980424 0.6147597699999428 0.8085691396689721 1.064488660105373 0.9011445228765596 0.6634912153515024 1.0321244309822972 1.0 13.172810394391961 -6.530249892483705 24.969734992998042 0.9123022430633002 0.7406717141575104 0.3350877803069344 0.13362677390796304 246.44169398008341 834813.1393357253 0.04451855361565407 0.04460564603281985 2.949511593145729e-07 6.530249892483705 -0.17163052890578978 SGCS(ph)DLEEAVDSGADKK ddPTM_A459_Selumetinib_30min_R1 3 SGCSDLEEAVDSGADKK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 S(0.085)GCS(0.915)DLEEAVDSGADKK;S(0.223)GCS(0.777)DLEEAVDSGADKK;S(0.005)GCS(0.995)DLEEAVDSGADKK 188.54 3.5030000000000003e-08 29043800.0 9664.2 12265.3 12741.5 12998.7 10289.0 11396.0 10971.800000000001 11112.1 6552.48 9940.500000000002 True False 9889.35705674028 10829.272974016725 11011.27428404966 10728.721060819034 9358.361766670485 11281.366586740118 10144.188292553146 10817.371010812232 11119.07998579576 11216.460003669581 0.8816825498869407 0.96548046090066 0.9817067310405606 0.9565157863808209 0.8343418300969111 1.0057867262085634 0.9044019493881643 0.9644193450761842 0.9913181148203657 1.0 13.453329802288456 -8.080245290268918 3.3446690977074045 0.9953291170569055 0.9357364469819383 0.2164691553970528 0.04760005072192531 0.41982160783190103 8.653594176617327 0.03621433932518128 0.012407417213114887 8.312941221386463e-09 8.080245290268918 -0.05959267007496727 SGCS(ph)DLEEAVDSGADKK ddPTM_A459_Selumetinib_30min_R2 1 SGCSDLEEAVDSGADKK 17 1 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 S(0.056)GCS(0.944)DLEEAVDSGADKK 116.98 0.000822 18878000.0 56380.0 47392.0 55940.0 62917.0 49383.0 46938.0 48945.0 52400.0 38958.0 47736.0 True False 53246.625307022274 51026.814010701986 52340.88130286682 54347.596062121156 43179.06605037861 53403.28343925945 51221.03948267756 52552.47532471303 46750.68857746862 46357.73764697694 1.148602757807241 1.100718382749412 1.1290646170322778 1.172352207434895 0.9314316927887094 1.1519820886415058 1.1049080926410948 1.1336289903728738 1.0084764906666517 1.0 15.500522541124033 -7.867836744082878 0.013887336584618945 8.116426981634464e-05 2.1499937664655673 0.23042675820958247 0.0666245579115609 830.900585567984 11.702088046643356 902.2596696718382 906.5340589184154 1.3556989382339578e-08 7.867836744082878 2.149912602195751 SGCSEAQPPES(ph)PETR ddPTM_A459_Selumetinib_30min_R1 1 SGCSEAQPPESPETR 15 0 A0A494BZT8;Q9Y6A5;H0Y8F2;A0A494C117 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 SGCSEAQPPES(0.925)PET(0.075)R 276.34 3.4037999999999997e-46 27871000.0 919.24 1132.1 1084.7 1571.0 1212.7 1059.1 1035.4 944.11 508.48 791.32 True False 940.6565034703269 999.5532057009883 937.4036978306059 1296.6543413223387 1103.011499119575 1048.4464155858604 957.2989443946776 919.0691358985185 862.8534220901746 892.8936301095333 1.0534922321653637 1.119453843094805 1.049849238722436 1.452193517343466 1.2353223966714446 1.1742120004341896 1.0721310043137429 1.0293153684899445 0.9663563418907204 1.0 9.802344507950034 -7.491402270618555 2.088109841318615 0.9936609192044398 1.1877572146690383 0.3727591871369099 0.10749714933919279 0.39008130611102365 3.3535835422445452 0.06720875107013997 0.03576362964107096 3.225505073761214e-08 7.491402270618555 0.1940962954645985 SGCSEAQPPES(ph)PETR ddPTM_A459_Selumetinib_30min_R2 2 SGCSEAQPPESPETR 15 0 A0A494BZT8;Q9Y6A5;H0Y8F2;A0A494C117 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 SGCSEAQPPES(1)PETR;SGCSEAQPPES(0.999)PET(0.001)R 165.16 8.845700000000001e-05 55140000.0 7900.200000000001 13064.599999999999 13546.6 15812.599999999999 16474.8 11674.0 9582.400000000001 13234.7 11359.900000000001 16489.0 True False 7461.138511006338 14066.612810689936 12675.026504422885 13658.896601743532 14405.088337419305 13281.987533979174 10028.000587165383 13273.210785877469 13632.197422126035 16012.919726432949 0.4659449143862278 0.8784539641118545 0.791549993440602 0.8529922609426707 0.8995916162397571 0.8294544505868126 0.6262443550885912 0.8289063464152031 0.8513249085751056 1.0 13.96694876615429 -14.522878745222217 0.028084244097050966 2.1158841046115295 1.377514381405448e-09 0.28093014400413663 0.12141652381734945 2763.6497100425318 5.828678988674678 333.476657362336 142.7283661595187 3.0000000004014843e-15 14.522878745222217 -2.115884103234015 SGCSSQSIS(ph)PMR ddPTM_A459_Selumetinib_30min_R1 1 SGCSSQSISPMR 12 0 C9JD37;Q14449-2;Q14449 C9JD37 GRB14 Growth factor receptor-bound protein 14 1 SGCSSQS(0.001)IS(0.999)PMR 86.699 0.037311 0.0 889.88 715.06 962.24 1160.3 916.94 851.72 998.74 757.45 471.25 749.37 True False 910.6124725949419 631.340442777625 831.5730932059764 957.675386528524 834.0029388989057 843.1524700998852 923.4042377098133 737.3599654556492 799.6768312617899 845.5589389819295 1.076935540048028 0.7466545661947255 0.9834596441109211 1.1325944796723277 0.9863333003173764 0.9971539903712192 1.0920637168375409 0.8720385196843238 0.945737540454149 1.0 9.723761509771744 -5.499703479914583 24.978562796331136 1.0054387876138435 0.9001105584370107 0.1135217150516894 0.1001555651872291 1353.1666423269216 1458455.8728307355 0.025630280350698396 0.052810014067235914 3.164437482731037e-06 5.499703479914583 -0.10532822917683282 SGCSSQSIS(ph)PMR ddPTM_A459_Selumetinib_30min_R2 1 SGCSSQSISPMR 12 0 C9JD37;Q14449-2;Q14449 C9JD37 GRB14 Growth factor receptor-bound protein 14 1 SGCSSQS(0.002)IS(0.998)PMR 86.756 0.029453 4343000.0 22295.0 18333.0 20081.0 19640.0 18807.0 14287.0 15190.0 22024.0 13641.0 18201.0 True False 21055.933153956394 19739.082150113943 18789.010322539656 16964.998119110263 16444.29652328676 16254.904565526846 15896.365098413982 22088.086193730513 16369.58116138534 17675.489838122736 1.1912503329069088 1.1167488047511094 1.0629979986192668 0.9598035627007024 0.9303446000019462 0.9196296518169498 0.8993450956096553 1.2496449261672302 0.926117539672321 1.0 14.109462576323205 -5.274649145910813 1.8564956774214345 0.9863273277450201 1.182061146845778 0.3429369226406572 0.09538451714025908 0.4988104325891812 3.0373009578810444 0.028436979797593596 0.1183497758335801 5.3131350387701125e-06 5.274649145910813 0.19573381910075793 SGDAAIVDMVPGKPMCVES(ph)FSDYPPLGR ddPTM_A459_Selumetinib_30min_R1 1 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 SGDAAIVDMVPGKPMCVES(0.607)FS(0.325)DY(0.068)PPLGR 78.584 4.3052e-05 19522000.0 1399.4 2440.5 2067.0 2416.8 2249.4 2076.5 1859.7 1929.1 800.18 1572.8 True False 1432.003297241608 2154.7651254423304 1786.3127532182752 1994.7512489546973 2045.9421671638245 2055.6122953111485 1719.4213317469412 1877.9340014000843 1357.847017165111 1774.6842003693496 0.8069059818888215 1.2141682024294114 1.0065524631630267 1.1240034979403926 1.152848583842703 1.1582975128100716 0.9688604493064699 1.0581792529675118 0.7651203616296997 1.0 10.793346608944088 -8.156806071634662 7.685374000722834 0.8835987173686755 1.0705703729350413 0.25226961594267483 0.1222944148044698 0.3235853782451111 20.629575569771337 0.07880462484379673 0.02950572372014886 6.969376527823954e-09 8.156806071634662 0.18697165556636586 SGDAAIVDMVPGKPMCVESFS(ph)DYPPLGR ddPTM_A459_Selumetinib_30min_R1 1 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 SGDAAIVDMVPGKPMCVES(0.325)FS(0.66)DY(0.014)PPLGR 63.462 0.00084965 13629000.0 847.9 2031.2 1862.1 2177.2 1907.3 1808.7 1762.2 1412.4 622.57 1328.3 True False 867.6544202738029 1793.3861597207394 1609.2370477831394 1796.9928911056645 1734.7850517611657 1790.506120168204 1629.275835244641 1374.938563878223 1056.4558192862655 1498.8002437376692 0.5788993055606054 1.1965478169715529 1.0736834708340224 1.1989542293003437 1.1574491390760677 1.1946262536647887 1.0870533562108284 0.9173594477469772 0.7048676591162698 1.0 10.549592402055508 -7.861982485901422 4.002122007586393 0.8413073034558306 1.0880402264882587 0.18804700655781048 0.1855340339792752 0.32123989080872506 9.401762755045068 0.10785401648747657 0.04874593082212012 1.3740973880855701e-08 7.861982485901422 0.2467329230324281 SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_A459_Selumetinib_30min_R1 4 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 ;;; 175.74 8.6256e-26 112676000.0 7897.78 8097.250000000001 8870.7 9885.4 8326.68 7901.2699999999995 8355.710000000001 7717.860000000001 4917.63 6267.57 False True 8081.782907595271 7149.220205690603 7666.107663267227 8159.100461940076 7573.533264194751 7821.790397579154 7725.432067479286 7513.157281657588 8344.85894051547 7072.073660801708 1.1427741416764459 1.0109086172725397 1.0839971458100137 1.1537069398984654 1.0709070107926726 1.1060108778183253 1.0923856902536153 1.0623697718677152 1.1799734195033083 1.0 12.787917586190058 -5.523081793528888 24.999315283518317 1.0986707110919738 1.0694942520363775 0.011727642631142787 0.05509918847622898 22.150332675222778 2727097.672150981 0.01389161308381493 0.024329364601613255 2.9985977202227775e-06 5.523081793528888 -0.029176459055596293 SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_A459_Selumetinib_30min_R2 2 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 ; 86.508 8.1398e-05 43907000.0 102790.0 89601.0 109779.0 121765.0 132667.0 85718.0 88540.0 96958.0 89392.0 108833.0 False True 97077.34330097238 96473.10858737589 102715.9386583376 105180.39694365895 116000.18540197183 97524.87642946953 92657.28543868153 97240.13172773906 107272.89782116855 105690.70850790675 0.9185040451659949 0.9127870363378131 0.9718540078729191 0.9951716515912123 1.0975438336974894 0.9227384110323537 0.876683359840944 0.9200442792042075 1.0149699943883281 1.0 16.689489026381914 -4.5289566290429715 0.004363579321934403 1.8999389948933332 1.7883615098610756e-05 0.041521108939331586 0.060906734175645655 218202.88824897597 138.20959677350956 29070.5206854753 31132.536885831618 2.9583078841612287e-05 4.5289566290429715 -1.8999211112782346 SGDEGS(ph)EDEAPSGED ddPTM_A459_Selumetinib_30min_R2 2 SGDEGSEDEAPSGED 15 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 S(0.005)GDEGS(0.995)EDEAPSGED;S(0.017)GDEGS(0.983)EDEAPSGED 148.62 0.00030118 2441700.0 20686.7 20610.4 19684.6 20002.0 21092.9 17295.8 18185.2 17196.4 16553.4 20821.4 True False 19537.016029421367 22191.151407118763 18418.114266971967 17277.693094625436 18443.02132908148 19678.13945435987 19030.847833290187 17246.438676982725 19864.54254064043 20220.23208150591 0.9662112655616136 1.0974726362026042 0.9108755128393299 0.854475508737023 0.9121073019705879 0.9731905833246168 0.9411785065858085 0.8529298084939829 0.9824092255997988 1.0 14.303511935688308 -5.280707271266989 24.542000702568807 0.921977887744658 1.031841954063713 0.35216624079780423 0.055579203405817595 547.4344750559737 697280.8133040905 0.014106162502995812 0.029439800105611785 5.239534794308294e-06 5.280707271266989 0.10986406631905488 SGDET(ph)PGSEVPGDK ddPTM_A459_Selumetinib_30min_R1 2 SGDETPGSEVPGDK 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 SGDET(1)PGSEVPGDK;SGDET(1)PGSEVPGDK 227.91 8.498600000000001e-13 58619000.0 16618.4 20522.6 13548.8 13912.6 14778.800000000001 15585.599999999999 18600.4 17797.3 10438.5 17656.5 True False 17005.57638622262 18119.804451302105 11708.94737823114 11483.025581846709 13442.060149409057 15428.82301459255 17197.356852732057 17325.257790222237 17713.372102124547 19922.883763874237 0.8535700246898237 0.9094970721135451 0.5877134814922094 0.5763736674842548 0.6747045412061919 0.7744271962560623 0.8631961645992071 0.8696159650159571 0.8890967950254194 1.0 14.28213886685129 -7.307156447235387 1.8989074306077696 0.9113684587631407 0.7161820338200655 0.42914585568281227 0.10222680797227333 0.4059399963613324 2.8536528422668823 0.061757742052166976 0.03743634607233416 4.929961784357001e-08 7.307156447235387 -0.19518642494307514 SGDET(ph)PGSEVPGDK ddPTM_A459_Selumetinib_30min_R2 4 SGDETPGSEVPGDK 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.374)GDET(0.625)PGS(0.001)EVPGDK;SGDET(0.998)PGS(0.002)EVPGDK;SGDET(0.905)PGS(0.095)EVPGDK;S(0.012)GDET(0.974)PGS(0.014)EVPGDK 202.92 9.6788e-05 81107200.0 185658.0 153299.0 169960.0 185681.0 184102.0 147980.0 180873.0 187841.0 139168.0 155636.0 True False 175339.8716078599 165056.54036602366 159024.95863845636 160390.9274824088 160973.46086723753 168362.90177130705 189283.95289305027 188387.5862112482 167005.48867881225 151142.384289109 1.1600972978728807 1.0920599217906957 1.0521533015799815 1.0611909309013476 1.0650451335961684 1.1139357273156298 1.252355213154393 1.2464246021876673 1.1049547052225925 1.0 17.205548761208327 -7.012802503925996 22.89934253353216 1.1731370935995136 1.083801213402421 0.11961731750980364 0.07350222116597248 288.8423515690607 516641.0195267067 0.02660868229749345 0.021689726984182114 9.709514084897468e-08 7.012802503925996 -0.08933588019709249 SGDETPGS(ph)EVPGDKAAEEQGDDQDSEK ddPTM_A459_Selumetinib_30min_R1 1 SGDETPGSEVPGDKAAEEQGDDQDSEK 27 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.005)GDET(0.065)PGS(0.93)EVPGDKAAEEQGDDQDSEK 85.01299999999998 3.5519e-05 7075500.0 993.44 1031.9 1456.2 1338.7 919.51 910.49 726.2 1053.9 611.36 663.32 True False 1016.5852191022608 911.0846682827047 1258.456038334036 1104.9211755112772 836.3404828526759 901.3312972587759 671.422149333026 1025.947148450338 1037.4332680322714 748.4635832839501 1.3582293672083594 1.2172732095865508 1.6813857967710988 1.476252419207008 1.1174097197664021 1.2042420197708286 0.8970672245496595 1.370737563408101 1.386083827192288 1.0 9.54778831301398 -6.25988767081108 24.982846731264466 1.1699333897742454 1.4355772500008959 0.36148506407072833 0.17607615436987434 169.06640260561323 2722008.114847622 0.05549099957351131 0.06784705001226703 5.496830296228665e-07 6.25988767081108 0.26564386022665043 SGDETPGS(ph)EVPGDKAAEEQGDDQDSEK ddPTM_A459_Selumetinib_30min_R2 2 SGDETPGSEVPGDKAAEEQGDDQDSEK 27 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.005)GDET(0.496)PGS(0.498)EVPGDKAAEEQGDDQDSEK;S(0.018)GDET(0.357)PGS(0.624)EVPGDKAAEEQGDDQDS(0.001)EK 58.361 0.0037035 11951600.0 33695.0 39437.0 34705.0 33962.0 28627.0 18471.5 12220.8 14150.9 8792.7 31262.0 True False 31822.36679177215 42461.69109005858 32472.11808394699 29336.3170122822 25030.620331372895 21015.78145741788 12789.091415055796 14192.076776192389 10551.485688564833 30359.384831569336 1.0481887880245033 1.3986347656789346 1.0695907793948682 0.9663014311731609 0.8244771911631325 0.6922334419492101 0.42125660602177306 0.4674691814385744 0.3475526841898597 1.0 14.889854937449211 -6.33246515184989 1.0986284117971878 0.5185280536595415 1.21680978398238 0.6464191719603734 0.1904370643012097 0.2764093644773245 0.698421457372182 0.08129965884789765 0.11348631042607599 4.650876936924036e-07 6.33246515184989 0.6982817303228385 SGDWVCPNPSCGNMNFAR ddPTM_A459_Selumetinib_30min_R1 2 SGDWVCPNPSCGNMNFAR 18 0 Q92804-2;Q92804;A0A075B7D9;A0A075B7F4 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 ; 179.35 2.3501e-07 26104000.0 3537.6 4682.9 4959.2 5070.3 4250.7 3768.0 3419.5 3778.0 2573.5 3243.0 False True 3620.0191970286623 4134.623890978855 4285.767878935687 4184.867286318687 3866.224935522036 3730.0973410702695 3161.5643619447574 3677.79516732648 4367.041538996741 3659.2706394950383 0.9892734245882965 1.1299038246456168 1.1712082273114137 1.143634264476316 1.0565561600700724 1.019355414931814 0.8639875738682827 1.0050623552222413 1.1934185714121905 1.0 11.837340405946675 -6.541467423887996 3.355782854099815 1.0077590054983738 1.1139894050102335 0.19485027928802023 0.08684743808968969 0.38036997264798894 8.999117796991003 0.03104876302878073 0.032577380354638745 2.874303184912587e-07 6.541467423887996 0.10623039951185964 SGECS(ph)PVPMGSFPR ddPTM_A459_Selumetinib_30min_R2 1 SGECSPVPMGSFPR 14 0 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7;E7EMH9 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.239)GECS(0.761)PVPMGSFPR 109.95 0.0044037 5337100.0 15868.0 13994.0 14303.0 19700.0 17661.0 15717.0 12104.0 10256.0 8952.0 13443.0 True False 14986.120084636916 15067.294802197912 13382.76055192893 17016.82601560448 15442.26728865676 17881.87408527932 12666.859983620992 10285.843262027804 10742.650139778712 13054.86566089139 1.1479336880141944 1.1541516545310135 1.025116680596708 1.3034853408397746 1.1828744691657254 1.3697478434303811 0.970278845654249 0.7878934589760829 0.8228847709984939 1.0 13.672299991442795 -7.476154347963215 6.167936400633031 0.8577119365117498 1.1911084805869223 0.6887452168021287 0.10094090516338773 0.11521927002952818 11.057658631782898 0.04410906521480793 0.028812696650395334 3.3407628843976446e-08 7.476154347963215 0.3333965440751725 SGEHDFGAAFDGDGDR ddPTM_A459_Selumetinib_30min_R1 2 SGEHDFGAAFDGDGDR 16 0 A0A3B3ITK7;P36871;P36871-2;P36871-3 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 0 ; 108.66 0.0043645 16233200.0 6538.700000000001 8597.5 5567.6 5954.6 7309.2 6350.9 8303.5 6149.7 2585.98 4778.2 False True 6691.038987904608 7590.900703130683 4811.550500637672 4914.740891685553 6648.084150544067 6287.015712155825 7677.160309813802 5986.5899789591485 4388.219187493605 5391.528513609372 1.2410282113903308 1.407931105987778 0.8924279058326945 0.9115672632129637 1.2330611131449791 1.1660915260461022 1.4239302065147215 1.1103697149792893 0.8139100398739988 1.0 12.396478623759975 -8.108060284969321 5.758516823367283 0.9136026484069276 1.1769532046707727 0.28713048359007454 0.17059572011631682 0.32366102342679637 14.370374099959623 0.12733502845873484 0.046855269414838426 7.797218688266721e-09 8.108060284969321 0.26335055626384507 SGEISLPIKEEPS(ph)PISK ddPTM_A459_Selumetinib_30min_R1 2 SGEISLPIKEEPSPISK 17 1 Q9ULH7-4;Q9ULH7;Q9ULH7-5;I3L2A0 Q9ULH7-4 MKL2 MKL/myocardin-like protein 2 1 SGEISLPIKEEPS(0.877)PIS(0.123)K;SGEISLPIKEEPS(0.997)PIS(0.003)K 93.776 0.0039323 53284000.0 4405.8 5270.9 5705.1 6408.4 4691.299999999999 4538.4 4290.299999999999 4931.1 3155.3 4056.0 True False 4508.446567805545 4653.780577625072 4930.378755871111 5289.293240566568 4266.972743316286 4492.747816537502 3966.679216859651 4800.311209529811 5354.313646005998 4576.6271087856585 0.9851024478596413 1.0168581505561822 1.0772952741564552 1.1557186362010614 0.9323400490997104 0.981672246775986 0.8667254557936122 1.048875317002504 1.1699256939083873 1.0 12.16006903449421 -1.5295265470033885 17.5681142753038 1.021750692879059 0.00277628977239619 0.0 0.0889930779227605 0.0 0.0 0.021383305721309673 0.0 0.029544282884067553 1.5295265470033885 -1.0189744031066628 SGEISLPIKEEPS(ph)PISK ddPTM_A459_Selumetinib_30min_R2 2 SGEISLPIKEEPSPISK 17 1 Q9ULH7-4;Q9ULH7;Q9ULH7-5;I3L2A0 Q9ULH7-4 MKL2 MKL/myocardin-like protein 2 1 SGEISLPIKEEPS(0.911)PIS(0.089)K;SGEISLPIKEEPS(0.968)PIS(0.032)K 77.66 0.010804 17680100.0 68102.0 69048.0 60591.0 78900.0 67288.0 55599.0 64251.0 55351.0 51366.0 84110.0 True False 64317.163473906134 74343.75957568696 56692.64102649276 68153.68388990824 58834.6798776477 63257.25757252943 67238.79881094115 55512.06224614867 61640.6352859555 81681.52575597526 0.7874138353641261 0.9101661469668185 0.6940693198589708 0.8343830904128596 0.7202935955606063 0.7744377567274073 0.8231824539103008 0.6796158829352889 0.7546459828640785 1.0 16.317722194590097 -10.980157828215784 3.1904883065172553 1.004162688523719 0.7756109539429206 0.5117812652535194 0.06582296563949418 23918936.679315254 29387888.425824083 883650.5752498186 0.016728232994923806 1.0467480771700062e-11 10.980157828215784 -0.22855173458079836 SGELGLPGAPESSTASAPGEPSPPS(ph)PPCR ddPTM_A459_Selumetinib_30min_R1 2 SGELGLPGAPESSTASAPGEPSPPSPPCR 29 0 Q5QP82;Q5QP82-2 Q5QP82;Q5QP82-2 DCAF10 DDB1- and CUL4-associated factor 10 1 SGELGLPGAPESSTASAPGEPS(0.023)PPS(0.977)PPCR;SGELGLPGAPESSTASAPGEPS(0.004)PPS(0.996)PPCR 152.13 4.3797e-16 16093100.0 5791.4 6814.2 7014.3 7233.6 6187.5 5716.2 6488.299999999999 6251.8 3247.6 5184.4 True False 5926.328351897277 6016.390296164362 6061.796586791943 5970.387551489036 5627.841717491854 5658.700217894335 5998.8823072397 6085.981955291609 5510.940004680719 5849.868240332431 1.013070398925857 1.028465949828379 1.03622788373221 1.0206020556712156 0.9620458933912741 0.9673209695356775 1.0254730637999465 1.0403622278757103 0.9420622445280149 1.0 12.514188415142794 -6.03022981106414 22.479156965097584 0.9921635000719866 1.0265490567057014 0.2726640747268674 0.027941798223266368 289.5510953433433 215312.6633068082 0.008577064163911201 0.01109753180598678 9.327605910264861e-07 6.03022981106414 0.03438555663371479 SGELGLPGAPESSTASAPGEPSPPS(ph)PPCR ddPTM_A459_Selumetinib_30min_R2 2 SGELGLPGAPESSTASAPGEPSPPSPPCR 29 0 Q5QP82;Q5QP82-2 Q5QP82;Q5QP82-2 DCAF10 DDB1- and CUL4-associated factor 10 1 SGELGLPGAPESSTASAPGEPS(0.007)PPS(0.993)PPCR;SGELGLPGAPESSTASAPGEPS(0.008)PPS(0.992)PPCR 115.61 9.7437e-14 6393400.0 56295.0 51468.0 58684.0 60824.0 60148.0 47340.0 45133.0 49494.0 37980.0 57660.0 True False 53166.3492667403 55415.4301042963 54908.335330308146 52539.66627274756 52591.67051005755 53860.65529026679 47231.77392934285 49638.019345827226 45577.06124986546 55995.20598132837 0.949480376667757 0.9896459729565885 0.9805899338707202 0.9382886508224819 0.9392173774232435 0.9618797599963584 0.8434967440800613 0.8864690909857363 0.8139457735911027 1.0 15.773015695951402 -7.2470866129750835 23.838571928028703 0.8765169951163091 0.9602294710238691 0.3597163502976466 0.047616852544547006 400.1168459403857 664556.4588754401 0.017232324999621348 0.013276675823682617 5.661263730761126e-08 7.2470866129750835 0.08371247590756004 SGEQAEGS(ph)PGGPGDSQGR ddPTM_A459_Selumetinib_30min_R1 5 SGEQAEGSPGGPGDSQGR 18 0 P38936 P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 1 S(0.353)GEQAEGS(0.647)PGGPGDSQGR;SGEQAEGS(1)PGGPGDSQGR;SGEQAEGS(0.962)PGGPGDS(0.037)QGR;SGEQAEGS(0.999)PGGPGDSQGR;S(0.014)GEQAEGS(0.977)PGGPGDS(0.009)QGR 150.23 0.0001204 71652850.0 2638.23 3044.3700000000003 3417.1299999999997 3233.09 2812.91 3068.01 3287.22 2689.64 1855.1399999999999 2405.2899999999995 True False 2699.695625898048 2687.9337451107854 2953.1025149515053 2668.4915241157482 2558.4827871595962 3037.1486049302002 3039.2623488439945 2618.3020100179983 3148.0370859352724 2714.0324010086415 0.9947175372315875 0.9903838082816709 1.0880866838045176 0.9832202162081896 0.9426868987300089 1.119053922790854 1.1198327432327206 0.9647276167539245 1.1599113867488604 1.0 11.406222228888073 -6.768973561124655 24.99849036376586 1.0734460779447186 1.0032764505047373 0.2464004790382669 0.06358277436865825 268.0068329396267 889243.4498237399 0.02185611665088418 0.019645289047305253 1.7022621351467735e-07 6.768973561124655 -0.07016962743998123 SGEQAEGS(ph)PGGPGDSQGR ddPTM_A459_Selumetinib_30min_R2 2 SGEQAEGSPGGPGDSQGR 18 0 P38936 P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 1 S(0.42)GEQAEGS(0.578)PGGPGDS(0.002)QGR;S(0.015)GEQAEGS(0.985)PGGPGDSQGR 186.58 1.8765e-10 20875000.0 9679.02 10351.300000000001 12114.81 12524.73 11227.28 8202.07 10275.1 10918.699999999999 8307.25 9795.13 True False 9141.098816586991 11145.211425324525 11335.3563142078 10818.840167635626 9816.808713243312 9331.830691521722 10752.912509724394 10950.471609311906 9968.932123958533 9512.319146095886 0.960974781879427 1.1716607962947525 1.1916501265477555 1.1373504191221309 1.0320100243138286 0.9810258201178793 1.1304196531439634 1.1511884158981647 1.0480022769263428 1.0 13.215581404157541 -6.249138041076803 24.3688074722456 1.0645286225880959 1.1248728097681322 0.11411048299539106 0.07614812557690703 1241.0886258498026 2458581.2034727326 0.023492788362767848 0.0300729621314031 5.634585313188435e-07 6.249138041076803 0.06034418718003631 SGEQAEGS(ph)PGGPGDSQGRK ddPTM_A459_Selumetinib_30min_R1 1 SGEQAEGSPGGPGDSQGRK 19 1 P38936 P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 1 S(0.014)GEQAEGS(0.986)PGGPGDSQGRK 65.854 0.011973 8601000.0 1125.6 1056.6 1981.9 2046.4 1216.7 1574.6 1170.4 1027.8 843.7 705.58 True False 1151.8242899636657 932.8927807999866 1712.7688657974368 1689.034655685574 1106.6496998258322 1558.7609536224095 1082.1157857055548 1000.5394052350865 1431.6972785900728 796.148065931209 1.4467463267858882 1.1717578936888267 2.1513195083807792 2.1215082067806152 1.3900048837416281 1.95787821427314 1.3591891157078497 1.2567252852204227 1.7982801690480754 1.0 9.636892954864893 -7.294537967149544 23.20119757008658 1.3749421698590067 1.7069198214792043 0.1957755735008071 0.34941358014168655 524.0173929114823 367318.3319107337 0.15102245651015872 0.1018322049753616 5.0753036746886306e-08 7.294537967149544 0.33197765162019754 SGEQAEGSPGGPGDS(ph)QGR ddPTM_A459_Selumetinib_30min_R1 1 SGEQAEGSPGGPGDSQGR 18 0 P38936 P38936 CDKN1A Cyclin-dependent kinase inhibitor 1 1 SGEQAEGS(0.006)PGGPGDS(0.994)QGR 132.5 0.00048092 1640400.0 500.55 453.67 531.06 541.91 408.49 413.39 355.6 225.68 286.36 298.21 True False 512.2118410992475 400.5541054945388 458.94496890377235 447.27559141055923 371.54215162476686 409.23167192808876 328.7768057047975 219.69423328804672 485.9320050931056 336.48815831138336 1.5222284304734757 1.190395844848333 1.363926062679057 1.3292461572946472 1.1041760087169095 1.2161844683680938 0.9770828410566239 0.6529033128254799 1.4441281010650846 1.0 8.394411924191154 -6.558011722381665 1.2046299810895955 1.0046755967451961 1.3539327483703298 0.32974384497841924 0.20079824941991103 0.5247925577259197 1.6009614128593885 0.09001841664255729 0.09851922490318153 2.7668669617357405e-07 6.558011722381665 0.3492571516251337 SGETSVRFT(ph)AGR ddPTM_A459_Selumetinib_30min_R2 1 SGETSVRFTAGR 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 SGETSVRFT(1)AGR 133.99 0.017233000000000002 13044000.0 10847.0 9241.2 9545.7 13513.0 8226.2 9279.4 7031.8 9214.0 12644.0 11326.0 True False 10244.167163981387 9949.97032485861 8931.54005457233 11672.50608877479 7192.751212838917 10557.553119993692 7358.792633247365 9240.81121454019 15173.153302877798 10998.988951517944 0.9313735297977196 0.9046259041368924 0.8120328235569061 1.0612344589330545 0.653946580412399 0.9598657809849577 0.6690426425268657 0.8401509679910069 1.379504368061374 1.0 13.425083294056714 -8.24074670248385 24.58709716819369 1.189752166161465 0.8519188501232521 0.4608417072002179 0.14523586188572682 459.76895825452914 546300.8555618086 0.09191541125108663 0.0346541831051063 5.744514070342641e-09 8.24074670248385 -0.33783331603821287 SGEVAEGEARS(ph)PSHK ddPTM_A459_Selumetinib_30min_R1 2 SGEVAEGEARSPSHK 15 1 O00257 O00257 CBX4 E3 SUMO-protein ligase CBX4 1 SGEVAEGEARS(0.865)PS(0.135)HK;SGEVAEGEARS(0.828)PS(0.172)HK 71.87899999999998 0.020379 9866400.0 3444.1 4419.6 6547.6 7781.8 5462.5 4955.2 4203.4 3829.3 1983.52 2783.7 True False 3524.3408289479944 3902.1511773837046 5658.471883392349 6422.854712477517 4968.417839482703 4905.355186961621 3886.3341538232444 3727.7345246805976 3365.888569431057 3141.0150105341777 1.1220388368499474 1.2423217222130003 1.8014787781705122 2.0448341351241144 1.581787359442688 1.5617102021194704 1.2372860813429585 1.1867929672983764 1.0715926406409106 1.0 11.617015122135083 -7.437185855042671 1.9506783010664204 1.0818479998173047 1.5844944600688797 0.4366626461255134 0.2461839123456445 0.3775568677045153 2.8114748975893 0.15967130732724635 0.0874207908951074 3.65438369872797e-08 7.437185855042671 0.502646460251575 SGEVAEGEARS(ph)PSHK ddPTM_A459_Selumetinib_30min_R2 2 SGEVAEGEARSPSHK 15 1 O00257 O00257 CBX4 E3 SUMO-protein ligase CBX4 1 SGEVAEGEARS(0.8)PS(0.2)HK;SGEVAEGEARS(0.5)PS(0.5)HK 66.215 0.02732 14636500.0 108722.0 144633.0 127225.0 128517.0 131957.0 75846.0 44309.0 55817.0 34120.0 155514.0 True False 102679.66648864985 155725.88603160612 119039.48201210643 111012.76289580899 115379.3819494524 86293.09803856311 46369.456296617835 55979.41822899821 40944.95339245418 151023.90674610285 0.6798901491885786 1.0311340064418284 0.7882161478727489 0.735067482279084 0.7639809116011347 0.571387006850754 0.3070338815600424 0.3706659391556414 0.2711157079341729 1.0 17.20441741745767 -6.836351614260219 2.5891091024336665 0.4338759868960122 0.8165214452352464 0.3241310100832173 0.21013632915176972 0.2717395990080472 3.7133324471345346 0.0773259210204587 0.06848544697566929 1.4576336505032562e-07 6.836351614260219 0.3826454583392342 SGFGEIS(ph)SPVIR ddPTM_A459_Selumetinib_30min_R1 2 SGFGEISSPVIR 12 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 SGFGEIS(0.5)S(0.5)PVIR;SGFGEIS(0.5)S(0.5)PVIR 190.78 0.00010447 153950000.0 11039.8 11996.2 12470.6 14047.3 12754.8 9776.1 11281.1 10937.1 6097.1 8888.0 True False 11297.00586028862 10591.679327117918 10777.161016102478 11594.202755478864 11601.130592042839 9677.761309988602 10430.15754453428 10647.012579292343 10346.333385435026 10028.861376451407 1.1264494977281192 1.056119825525563 1.0746146159132421 1.1560836589787757 1.156774448920318 0.9649910340482702 1.0400141305198565 1.0616372267635892 1.0316558377932183 1.0 13.29187019887996 -6.7557599186962864 24.999990497432375 1.0247841272482987 1.1109413440358724 0.6030551493425074 0.03811934715816053 115.28894839192166 507482.18294828676 0.013810340046081813 0.01344586268713235 1.754850328406172e-07 6.7557599186962864 0.08615721678757371 SGFGEISS(ph)PVIR ddPTM_A459_Selumetinib_30min_R1 1 SGFGEISSPVIR 12 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 SGFGEIS(0.253)S(0.747)PVIR 167.2 0.00043922 5379300.0 3025.2 3286.7 3846.4 4376.3 3608.1 3500.5 3626.6 3181.8 1902.3 2653.2 True False 3095.6812739855036 2901.891636054623 3324.080006762831 3612.061358325243 3281.747992061795 3465.2881481997015 3353.0426422075902 3097.4083280570144 3228.06416150515 2993.7640643565323 1.034043166875569 0.9693120679095145 1.110334660749993 1.2065283972541787 1.0961945970071494 1.1575020855708336 1.1200089820465795 1.0346200507028795 1.0782627127962996 1.0 11.547744813140888 -8.538646395696077 1.2037548243779423 1.0035740445172612 1.0981125291193474 0.16249890252701626 0.0631525428118653 1.0411016758371134 3.3027844106886954 0.06664157463563121 0.020797837108514558 2.8930344439022537e-09 8.538646395696077 0.09453848460208625 SGFGEISS(ph)PVIR ddPTM_A459_Selumetinib_30min_R2 4 SGFGEISSPVIR 12 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 SGFGEIS(0.167)S(0.833)PVIR;SGFGEIS(0.016)S(0.984)PVIR;SGFGEIS(0.337)S(0.663)PVIR;SGFGEIS(0.08)S(0.92)PVIR 186.76 0.00011251 82508000.0 233398.0 229275.0 261050.0 290385.0 315173.0 243692.0 240793.0 235404.0 203825.0 258325.0 True False 220426.67352622162 246859.6552646792 244254.32720974993 250834.0620579347 275578.15005763044 277258.360984277 251990.35162227773 236088.98666677013 244595.6953463354 250866.4860410449 0.8786613030891541 0.9840280348339948 0.9736427175441317 0.9998707520337934 1.0985052423963175 1.1052028724909633 1.0044799351199465 0.9410941668316071 0.9750034737853205 1.0 17.93656022437132 -4.184004357779738 1.0817678508596797 1.0187758113555014 0.5595719944279205 0.40564136385057337 0.049003654056209225 6.25738902249927 2.4330272703121336 0.017531144800090298 4.504845772083183 6.546296053769932e-05 4.184004357779738 -0.45920381692758094 SGGGGGGGGSSWGGR ddPTM_A459_Selumetinib_30min_R2 1 SGGGGGGGGSSWGGR 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 128.08 0.013862 781990.0 0.0 0.0 0.0 1056.0 637.46 829.7 0.0 801.28 616.65 0.0 False True 0.0 0.0 0.0 912.1709782983932 557.3765758352943 943.9836437332984 0.0 803.6115921409546 739.997230640588 0.0 0.0 SGGGLHSVAEGVRLS(ph)PEPGR ddPTM_A459_Selumetinib_30min_R1 3 SGGGLHSVAEGVRLSPEPGR 20 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 S(0.014)GGGLHS(0.152)VAEGVRLS(0.834)PEPGR;S(0.009)GGGLHS(0.136)VAEGVRLS(0.854)PEPGR;SGGGLHSVAEGVRLS(1)PEPGR 80.41 0.0022599 64712000.0 12135.7 11921.0 14742.099999999999 16199.3 15584.0 13159.699999999999 12931.0 11301.1 4455.49 7709.4 True False 12418.43819803843 10525.283778077453 12740.203792558843 13370.396353521943 14174.429951578662 13027.325366051595 11955.60425919218 11001.358116853713 7560.6411138856065 8698.976585915223 1.4275746204611586 1.2099450635514135 1.4645635227006926 1.5370079711641433 1.6294364988323928 1.4975698850764276 1.3743690583728965 1.2646726897352898 0.8691414489064461 1.0 13.086629965936861 -8.034060631836983 2.349017489290464 0.9324600664134918 1.4550719818675084 0.7756688232788289 0.10904912408143182 0.1560773311925783 1.58624111510761 0.1000256266467256 0.03336878756886258 9.245690858706502e-09 8.034060631836983 0.5226119154540166 SGGGLHSVAEGVRLS(ph)PEPGR ddPTM_A459_Selumetinib_30min_R2 2 SGGGLHSVAEGVRLSPEPGR 20 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 SGGGLHSVAEGVRLS(1)PEPGR;SGGGLHSVAEGVRLS(1)PEPGR 67.153 0.0081572 100106000.0 53104.0 59982.0 64125.0 75149.0 85019.0 49829.0 35941.0 46868.0 34197.0 65305.0 True False 50152.69227215521 64582.42652747149 59999.267314020995 64913.57656074431 74338.15314049649 56692.492447374374 37612.3277157404 47004.37812058494 41037.355544013946 63419.47496723285 0.7908090109239752 1.018337451718727 0.9460700730338909 1.023559034417794 1.1721660133406187 0.8939287573204583 0.5930722027448775 0.7411663080602741 0.6470781343619898 1.0 15.952638313356625 -7.009063641316303 23.997964523149 0.7265797564753257 0.9953443144466216 0.4283143224016738 0.13265348887929232 218.75926782806673 579213.7030902776 0.04681691238260886 0.03915778081829384 9.793464619069025e-08 7.009063641316303 0.26876455797129595 SGGGPGPSGSET(ph)PPPPR ddPTM_A459_Selumetinib_30min_R1 2 SGGGPGPSGSETPPPPR 17 0 P27987-2;P27987 P27987-2 ITPKB Inositol-trisphosphate 3-kinase B 1 SGGGPGPSGS(0.001)ET(0.999)PPPPR;SGGGPGPSGS(0.002)ET(0.998)PPPPR 142.74 0.00056314 0.0 1268.18 1655.63 1197.97 1559.75 1714.96 1167.99 1421.1599999999999 1285.88 497.33 941.5799999999999 True False 1297.7261265512818 1461.7880699184943 1035.2922539781796 1287.368942633685 1559.8421708007804 1156.2410810500692 1313.96075701752 1251.7742852731021 843.9326864539544 1062.4409647658777 1.2214571628808122 1.3758769836596219 0.9744468524011773 1.211708683425411 1.4681683241990875 1.0882873678584688 1.2367376641082999 1.1782059679418955 0.7943337224764537 1.0 10.053166963836453 -8.165604329269335 5.536251397998167 0.9002752289300537 1.2233114625127408 0.4737023160994972 0.1362768103817717 0.18318295329560658 8.213660590744077 0.09557192927540409 0.034621675428709024 6.82960632673427e-09 8.165604329269335 0.32303623358268707 SGGGPGPSGSET(ph)PPPPR ddPTM_A459_Selumetinib_30min_R2 2 SGGGPGPSGSETPPPPR 17 0 P27987-2;P27987 P27987-2 ITPKB Inositol-trisphosphate 3-kinase B 1 SGGGPGPSGS(0.002)ET(0.998)PPPPR;SGGGPGPS(0.001)GS(0.005)ET(0.993)PPPPR 120.59 0.0034162 1852000.0 10142.7 12878.0 21553.5 27844.2 32685.5 21902.0 14835.6 21291.2 24857.1 21066.8 True False 9579.009338445097 13865.70119070351 20166.771275676438 24051.77192607585 28579.25527792254 24918.80169343943 15525.484796183697 21353.153867052097 29829.21456540367 20458.546745880132 0.46821553150514383 0.6777461450675002 0.9857382113290891 1.175634429210829 1.3969347692634975 1.218014260883779 0.7588752509662087 1.0437277941724827 1.4580319382367943 1.0 14.32041604775218 -5.212931954938235 1.9641622342348704 1.1477821055160298 0.46929565640668675 0.6037437792548838 0.18771872327721958 0.2882430996449887 1.9451372772223505 0.056516034356814446 0.25387793619282195 6.1244634202197875e-06 5.212931954938235 -0.678486449109343 SGGGYGGDRS(ph)SGGGYSGDR ddPTM_A459_Selumetinib_30min_R1 1 SGGGYGGDRSSGGGYSGDR 19 1 Q92804-2;Q92804;A0A075B7F4 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 1 SGGGY(0.003)GGDRS(0.497)S(0.497)GGGY(0.003)SGDR 68.26100000000001 0.010705 16849000.0 1143.2 1581.3 1880.2 1848.6 1491.5 1119.3 1579.8 1115.6 955.02 1105.8 True False 1169.8343357200276 1396.1606608735742 1624.8791671993224 1525.776712519718 1356.594088345713 1108.040858243087 1460.634414095723 1086.0106640204936 1620.5991880989595 1247.740201404136 0.9375624303870007 1.1189514125636204 1.3022576056864847 1.2228320533414692 1.0872408269117875 0.8880381164253269 1.1706238305474232 0.8703820417089702 1.2988274211852988 1.0 10.285101858955375 -6.517033891412954 24.79275899409443 1.038883289691697 1.1547557864998788 0.09220949028177161 0.14575027979235397 523.5217889172494 2220690.0872011282 0.04643115461772122 0.04791529315644845 3.0406477307686484e-07 6.517033891412954 0.11587249680818168 SGGIVIS(ph)PFR ddPTM_A459_Selumetinib_30min_R1 3 SGGIVISPFR 10 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 SGGIVIS(1)PFR;SGGIVIS(1)PFR;SGGIVIS(1)PFR 119.03 0.0055279 44990000.0 9775.0 13499.300000000001 9736.2 8845.2 9499.8 8793.4 11643.5 11066.4 5464.1 10095.5 True False 10002.738481161008 11918.795680345693 8414.077517118423 7300.551864967765 8640.544767325911 8704.94637976839 10765.221420764372 10772.883123266754 9272.178617925825 11391.355763497435 0.8780990330592496 1.0463017684460696 0.7386370588196859 0.6408852481248738 0.7585176818911892 0.7641712330381779 0.9450342561734878 0.945706845342104 0.8139662047635875 1.0 13.475651841860973 -10.912700077257728 8.350535049550778 1.0000013134799213 0.8362709435593396 0.15654547611966574 0.11362992387721037 3.0810967266949522e-06 2.251240986770928e-07 0.12189119612819213 0.02956272001705203 1.2226437235416598e-11 10.912700077257728 -0.16373036992058165 SGGIVIS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 4 SGGIVISPFR 10 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 SGGIVIS(1)PFR;SGGIVIS(1)PFR;SGGIVIS(1)PFR;SGGIVIS(1)PFR 139.32 0.00154 72982300.0 116903.0 101473.0 111663.0 139973.0 128200.0 101433.0 127003.0 132314.0 110692.0 111671.0 True False 110405.9992597875 109255.65281287889 104478.7241494817 120908.43593310665 112094.3698774585 115404.47503290305 132908.89115167008 132699.01183423828 132833.4929928936 108446.76807389708 1.0180662939125615 1.0074588183064213 0.9634102150309218 1.1149104586567118 1.0336349516757928 1.0641578083199759 1.2255680230240165 1.2236327019336841 1.2248727680144333 1.0 16.726627532949635 -7.129246747859653 4.3380267528137235 1.1865405666816056 1.0293129535497478 0.4554459736792603 0.07190492079857211 0.18789972169954836 5.7485952193731515 0.027521658781705528 0.02111081262949393 7.425971055732949e-08 7.129246747859653 -0.15722761313185774 SGGIVIS(ph)PFRLEELTNR ddPTM_A459_Selumetinib_30min_R1 2 SGGIVISPFRLEELTNR 17 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 SGGIVIS(1)PFRLEELTNR;SGGIVIS(1)PFRLEELTNR 124.2 0.00072615 130300000.0 4684.1 5281.1 7054.9 7454.299999999999 6334.5 5163.6 4722.1 4481.3 3022.4 3524.7999999999997 True False 4793.230416328008 4662.786356883217 6096.883329791783 6152.546439541133 5761.545593446809 5111.658872173684 4365.90819521548 4362.44136668612 5128.792052637948 3977.242414459488 1.2051642612735773 1.1723666477887784 1.532942349107568 1.546937751939184 1.448628218511496 1.2852268832269218 1.0977224268108416 1.096850760422905 1.2895346871470383 1.0 11.95755278230439 -7.068359924176397 3.7994102992601855 1.1307130689604858 1.3866046871788602 0.4606729525558616 0.1323103494897836 0.24599602819677313 6.896812157719304 0.057539233382131176 0.04495495206952808 8.543583647435032e-08 7.068359924176397 0.25589161821837436 SGGIVIS(ph)PFRLEELTNR ddPTM_A459_Selumetinib_30min_R2 1 SGGIVISPFRLEELTNR 17 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 S(0.001)GGIVIS(0.999)PFRLEELTNR 77.726 0.010764 9500200.0 20841.0 30387.0 27808.0 27772.0 26081.0 23608.0 19563.0 16698.0 15384.0 29424.0 True False 19682.74065313322 32717.58519039504 26018.863555061158 23989.405690627795 22804.47161290169 26859.78770791334 20472.7182633491 16746.58841549728 18461.22986487442 28574.45266726683 0.688823015521154 1.1449942916273015 0.910563847295203 0.8395403394063471 0.7980720358302826 0.9399930777565617 0.716469305702622 0.5860685630798158 0.6460746625611659 1.0 14.80243824398107 -7.292373490829613 9.44134196331782 0.7024044733624243 0.8935824429007442 0.17818129350716916 0.15002810641674655 0.6441467303913012 190.30557741442385 0.0607526320877262 0.04129145710936838 5.100661572539544e-08 7.292373490829613 0.1911779695383199 SGGLQT(ph)PECLSR ddPTM_A459_Selumetinib_30min_R1 1 SGGLQTPECLSR 12 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 SGGLQT(1)PECLSR 145.49 0.0015942 13462000.0 2570.3 2718.6 3182.7 3231.2 2744.2 2326.9 2608.6 2470.7 1328.8 2277.5 True False 2630.1829890668173 2400.3050481571468 2750.5068213196905 2666.9315771360552 2495.987594527861 2303.4934986561598 2411.831201804092 2405.1690100353476 2254.876548287885 2569.8393097286316 1.0234814990609502 0.9340292364080199 1.0703030383678491 1.0377814546768982 0.9712621271994749 0.8963570173184886 0.938514401532279 0.9359219469210031 0.8774387331346386 1.0 11.327462436180282 -6.52500301563828 5.084135524196121 0.926444388278177 1.0137013016510454 0.4639059227520512 0.043828494098154355 0.16088074565528485 12.421622490785381 0.014246216985385942 0.014983272501468189 2.985361889198324e-07 6.52500301563828 0.08725691337286845 SGGLQT(ph)PECLSR ddPTM_A459_Selumetinib_30min_R2 2 SGGLQTPECLSR 12 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 S(0.005)GGLQT(0.995)PECLSR;SGGLQT(1)PECLSR 112.24 0.015113 72268000.0 262110.0 251290.0 291210.0 297560.0 293880.0 163504.0 212450.0 213671.0 175612.0 205408.0 True False 247542.9755094642 270563.1349752982 272473.8656454743 257031.81468036908 256960.16707946587 186025.19185846587 222329.34596168884 214292.7472348619 210739.30700925185 199477.33732592268 1.2409578893917552 1.3563602693033225 1.3659389547609802 1.288526396662339 1.2881672200166927 0.9325630387502237 1.114559422850269 1.074271143316559 1.056457389266874 1.0 17.605865325221792 -6.6826633347222435 7.167458573437304 1.0456574395442562 1.3150117062742555 0.8547689267771275 0.05607926459046653 0.08252656220352467 6.281205707439274 0.018544463462377783 0.018483392867220245 2.0765226149530975e-07 6.6826633347222435 0.2693542667299993 SGGLQTPECLS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 SGGLQTPECLSR 12 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 SGGLQTPECLS(1)R;SGGLQTPECLS(1)R;SGGLQTPECLS(1)R 175.01 0.0001195 137507000.0 5098.8 6226.9 4585.3 4254.0 4872.2 4763.4 5801.1 5642.5 2738.3599999999997 5003.700000000001 True False 5217.592119462276 5497.851653192726 3962.641445250002 3511.1187574699125 4431.510370256773 4715.484520821154 5363.518356507593 5492.842570576936 4646.796918098748 5645.973635165382 0.924126192684469 0.9737650241492286 0.7018526300882962 0.621880119241305 0.7848974608481262 0.8351942154761811 0.9499722639690443 0.9728778286114047 0.8230284479468056 1.0 12.463006676555437 -7.124019748155909 3.7510088772930836 0.9339212000956263 0.7963189346050585 0.27839342646620646 0.1029266863009848 0.37104343429823955 9.26200601543342 0.04607252701673079 0.03515151301147954 7.515887171422678e-08 7.124019748155909 -0.13760226549056775 SGGLQTPECLS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 SGGLQTPECLSR 12 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 SGGLQTPECLS(1)R;SGGLQTPECLS(1)R 175.66 0.00010346 321080000.0 658550.0 557180.0 712180.0 632710.0 693560.0 535780.0 578370.0 705570.0 548300.0 603610.0 True False 621950.4273845245 599913.9143839238 666359.1141629562 546533.806514372 606428.7922949316 609578.8316734085 605265.3510184137 707623.0918865977 657975.320782024 586182.2109328753 1.0610189387950313 1.0234256570652243 1.1367781241646415 0.932361638277277 1.03453974034769 1.0399135632302776 1.0325549628249016 1.207172579939702 1.1224757567018182 1.0 19.16098966118085 -7.707591235830886 24.999101013126854 1.1236186349553212 1.036492030321532 0.19300559592259758 0.06630830219822084 116.58338362041067 54123.708069801825 0.03000543585498 0.017323623366846987 1.960689234016778e-08 7.707591235830886 -0.0871266046337893 SGGS(ph)GGCSGAGGASNCGTGSGR ddPTM_A459_Selumetinib_30min_R2 1 SGGSGGCSGAGGASNCGTGSGR 22 0 E9PL01;A0A087WUC6;E9PI68;Q15005 E9PL01 SPCS2 Signal peptidase complex subunit 2 1 S(0.032)GGS(0.512)GGCS(0.455)GAGGASNCGTGSGR 112.44 4.1277e-05 624130.0 670.01 0.0 545.66 465.99 0.0 442.47 499.87 681.95 0.0 495.01 True False 632.77352646254 0.0 510.5528296696874 402.521358122413 0.0 503.41622615725254 523.1149454736138 683.9343615971 0.0 480.7177751095619 1.316309816749178 0.0 1.06206355600919 0.8373340428917426 0.0 1.047217831798538 1.0881955537308539 1.4227357443589896 0.0 1.0 8.909046339596072 SGGSGHAVAEPAS(ph)PEQELDQNK ddPTM_A459_Selumetinib_30min_R1 2 SGGSGHAVAEPASPEQELDQNK 22 0 P46013 P46013 MKI67 Antigen KI-67 1 SGGSGHAVAEPAS(1)PEQELDQNK;SGGSGHAVAEPAS(1)PEQELDQNK 258.76 4.136999999999998e-54 31785000.0 6543.4 14801.099999999999 5793.1 9199.7 11865.400000000001 9314.9 14103.5 7384.2 1294.1299999999999 5016.2 True False 6695.848488759997 13068.180331155292 5006.428839220508 7593.145094756923 10792.176665006522 9221.200563252503 13039.661640207012 7188.34702873801 2196.0440904844972 5660.078131925691 1.1829957701452987 2.3088339112218565 0.8845158534087592 1.3415265510077963 1.9067186730397254 1.629164889304317 2.3037953427986717 1.270008445323769 0.3879882996840101 1.0 12.466606252871847 -8.00578221407594 24.311352133759144 0.7389952803207049 1.6541863389614504 0.41743341554807434 0.44927192991096054 161.03222062896336 677055.3496611392 0.25357832372442224 0.11544834970020659 9.867741998504959e-09 8.00578221407594 0.9151910586407455 SGGSGHAVAEPAS(ph)PEQELDQNK ddPTM_A459_Selumetinib_30min_R2 4 SGGSGHAVAEPASPEQELDQNK 22 0 P46013 P46013 MKI67 Antigen KI-67 1 SGGSGHAVAEPAS(1)PEQELDQNK;SGGSGHAVAEPAS(1)PEQELDQNK;SGGSGHAVAEPAS(1)PEQELDQNK;SGGSGHAVAEPAS(1)PEQELDQNK 216.87 4.156e-26 68999000.0 170931.0 153410.0 263229.0 260175.0 314975.0 194840.0 160168.0 185149.0 189984.0 298270.0 True False 161431.3393110077 165176.05370910233 246293.1327220649 224738.71617309147 275405.0245877733 221677.44141858025 167616.12936687114 185687.75293693296 227986.1085964839 289658.1701014715 0.5573167131949219 0.5702447600605871 0.8502889203359423 0.7758756333175834 0.9507932211658139 0.7653070560409997 0.5786687436026844 0.6410582269158293 0.7870867530393395 1.0 18.143991832692322 -12.614090895835426 1.0624525066079509 5.006890980241576 0.7223915654283665 0.31312613231952147 0.12452711347057174 67417.53210026189 1480.9599405701463 645970.8145214517 0.04095181114743752 2.4316950132404916e-13 12.614090895835426 -4.28449941481321 SGIETFS(ph)PPPPPPK ddPTM_A459_Selumetinib_30min_R1 2 SGIETFSPPPPPPK 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 S(0.001)GIET(0.051)FS(0.948)PPPPPPK;SGIET(0.021)FS(0.979)PPPPPPK 110.38 0.004268500000000001 32325000.0 10265.7 12392.9 12345.2 13298.8 13499.8 10714.9 11988.5 11469.099999999999 5416.2 8864.8 True False 10504.870836425016 10941.933506697098 10668.78964732959 10976.414229393711 12278.745473583265 10607.117834350796 11084.197793003272 11164.902211112798 9190.895816403401 10002.683430464267 1.050205268361416 1.0938998102621385 1.0665927519845948 1.0973469575138048 1.2275451441547178 1.0604272251629656 1.108122422353699 1.1161906990986905 0.918843016506103 1.0 13.288099464798291 -8.254530949445797 24.8884276904215 0.95942150383594 1.1038308420663072 0.5666190845852412 0.050056530023631925 324.84115328263744 1170289.1747459737 0.035724127380713254 0.012855478319923534 5.565049742234791e-09 8.254530949445797 0.14440933823036717 SGIETFS(ph)PPPPPPK ddPTM_A459_Selumetinib_30min_R2 4 SGIETFSPPPPPPK 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 SGIET(0.007)FS(0.993)PPPPPPK;S(0.017)GIET(0.097)FS(0.886)PPPPPPK;S(0.002)GIET(0.008)FS(0.99)PPPPPPK;S(0.003)GIET(0.161)FS(0.836)PPPPPPK 159.66 0.00029659 38904300.0 188573.0 158739.0 191634.0 212249.0 202958.0 149358.0 159171.0 161832.0 146203.0 182643.0 True False 178092.86757752934 170913.770873667 179304.47707532367 183340.3200500522 177460.6015724591 169930.70876306863 166572.7668913528 162302.90432727005 175447.68525313554 177369.62202649593 1.0040776179301176 0.9636022725928539 1.0109086044539166 1.0336624612227248 1.0005129375871906 0.9580598234441969 0.9391279351459053 0.9150546890325155 0.9891642280600154 1.0 17.4363994158427 -6.7731579648521345 5.2463216561907275 0.9532199304389303 1.0028269368304414 0.35537372629915587 0.027740958802911 0.17951109813475538 14.161735404220707 0.009846814462600897 0.009101973771339401 1.6859396912000443e-07 6.7731579648521345 0.049607006391511166 SGIIPTS(ph)PTPYTYNK ddPTM_A459_Selumetinib_30min_R2 1 SGIIPTSPTPYTYNK 15 0 R4GN33;Q8IW41-2;Q8IW41;F8VRP2 R4GN33 MAPKAPK5 MAP kinase-activated protein kinase 5 1 SGIIPT(0.003)S(0.992)PT(0.004)PYTYNK 123.68 0.0016117 0.0 20611.0 21003.0 19571.0 24475.0 27786.0 20184.0 16906.0 17047.0 15482.0 17851.0 True False 19465.523132370272 22613.862564710802 18311.823167293645 21141.462778270045 24295.274270008296 22964.162787890662 17692.16249860348 17096.603947717234 18578.832603223203 17335.59524753196 1.1228644216956754 1.3044756895746223 1.0563134928926463 1.2195406316538175 1.4014675540758932 1.3246826809226542 1.020568503473931 0.9862138394210173 1.0717158734926187 1.0 14.081449754360676 -7.276584010689461 23.931189334221198 1.0184756577886114 1.2395377583488933 0.5616604642138179 0.09460053848005814 379.24600019988316 599272.3591823379 0.042063003745636054 0.028499380779133745 5.289516659704762e-08 7.276584010689461 0.22106210056028197 SGISTNHADYSSS(ph)PAGSPGAQVSLYNSPSVASPAR ddPTM_A459_Selumetinib_30min_R2 1 SGISTNHADYSSSPAGSPGAQVSLYNSPSVASPAR 35 0 Q8WV41 Q8WV41 SNX33 Sorting nexin-33 1 SGISTNHADYS(0.001)S(0.103)S(0.838)PAGS(0.059)PGAQVSLYNSPSVASPAR 135.87 4.091e-26 3613400.0 2516.6 2202.9 4476.9 4484.4 4578.8 3607.3 2385.9 3144.7 3139.8 4653.2 True False 2376.7374467479976 2371.8553465600835 4188.861128080166 3873.616983978517 4003.5702090086384 4104.172831190944 2496.849077571161 3153.850556366891 3767.8477333419582 4518.85002553446 0.5259606832087534 0.524880297676964 0.9269750278080395 0.8572129993449763 0.8859710294401998 0.9082339108400769 0.5525408153539795 0.6979321151499986 0.8338067676623816 1.0 12.141739961385957 -5.247204181322325 23.91087335875056 0.8174967416890929 0.5254203672184365 0.5081102339836656 0.12023154230240293 398.3640855576403 669126.6977988727 0.03253863256950391 0.08507015807883479 5.659731371117391e-06 5.247204181322325 -0.2920763744706564 SGITS(ph)PVEK ddPTM_A459_Selumetinib_30min_R1 1 SGITSPVEK 9 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 S(0.018)GIT(0.22)S(0.761)PVEK 118.23 0.0072794 13944000.0 6688.8 8135.6 5777.1 6740.5 6772.0 5889.3 7069.0 6489.4 3526.0 6078.3 True False 6844.636025860849 7183.080169862169 4992.601551338797 5563.398209855654 6159.473795693708 5830.058989056564 6535.7796387154485 6317.280031458041 5983.364471149221 6858.509012655779 0.9979772590851262 1.04732386537766 0.7279426974763925 0.8111672959224374 0.8980776702819572 0.850047580064202 0.9529446745138326 0.9210864955926972 0.8724001762056909 1.0 12.743679264290435 -7.271800523945333 24.38622454772771 0.9300317079260186 0.8855509371121657 0.062123881605318565 0.08911948572599036 1957.7043841044817 4607672.175190911 0.04000675302291884 0.02733340197566484 5.3480994686436254e-08 7.271800523945333 -0.04448077081385293 SGITS(ph)PVEKR ddPTM_A459_Selumetinib_30min_R1 1 SGITSPVEKR 10 1 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 S(0.001)GIT(0.024)S(0.975)PVEKR 107.03 0.020726 8340200.0 3995.6 3610.2 6029.3 5679.0 5027.9 4243.4 4182.6 4603.8 2383.3 3217.3 True False 4088.689705915798 3187.5161056635548 5210.554176574239 4687.269258032824 4573.127332747842 4200.71524869893 3867.1031145694205 4481.69226875004 4044.2860306551133 3630.2717941558426 1.126276471226737 0.8780378677968262 1.4353069059353623 1.2911620737539757 1.2597203713809655 1.1571351917675723 1.0652379033423445 1.2345335343664483 1.1140449696261772 1.0 11.825861849798203 -6.996898286973027 23.93553930585922 1.1213111258492652 1.1996436828982227 0.08250470403785604 0.14389848278303802 190.8614455821659 1472824.940304819 0.05405536018163338 0.047387963662865316 1.0071675227861788e-07 6.996898286973027 0.07833255704895747 SGKNS(ph)QEDSEDSEDKDVK ddPTM_A459_Selumetinib_30min_R1 1 SGKNSQEDSEDSEDKDVK 18 2 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 S(0.042)GKNS(0.95)QEDS(0.008)EDSEDKDVK 81.37899999999998 0.011845 16572000.0 752.37 628.2 963.8 626.9 482.66 788.79 529.99 631.39 373.42 589.0 True False 769.8987571428248 554.6500519577429 832.9212537744431 517.4236833704487 439.00348822054434 780.8554887640169 490.012427602603 614.6434861562379 633.6664664822862 664.6038873458457 1.1584325216896993 0.8345573393691494 1.2532596778823966 0.7785444732152047 0.6605490828134387 1.174918629926214 0.7372999721074622 0.9248267996307861 0.953449834626892 1.0 9.376350921321329 -5.781719283388451 24.998869460252447 0.8827650535710656 1.0573307725000598 0.2087673469423328 0.16896836477890603 386.0129993535854 475833.7321837075 0.046168499161608124 0.06857154461856861 1.65302992836311e-06 5.781719283388451 0.1745657189289942 SGKNS(ph)QEDSEDSEDKDVK ddPTM_A459_Selumetinib_30min_R2 2 SGKNSQEDSEDSEDKDVK 18 2 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 S(0.002)GKNS(0.991)QEDS(0.006)EDSEDKDVK;S(0.017)GKNS(0.728)QEDS(0.255)EDSEDKDVK 119.38 0.0011039 11255400.0 62627.0 49342.0 46107.0 35291.0 40566.0 32483.0 46162.0 39796.0 26567.3 41547.0 True False 59146.44205574464 53126.37274046374 43140.525817505935 30484.304919629332 35469.7364153587 36957.23839868473 48308.62446826768 39911.799771417536 31881.502352384177 40347.43015793012 1.4659283583670732 1.3167225900760864 1.069226110526567 0.7555451437751054 0.8791076972317968 0.9159750262662252 1.197316019364193 0.9892030202467068 0.7901742992699128 1.0 15.300189166646604 -5.250997597960915 2.5802124905818418 0.9391267824912023 1.4376285939097808 0.7048664275479322 0.11806744974226173 0.1698942139349415 2.1698932595987785 0.03459722003689898 0.11462945528944257 5.610510791409599e-06 5.250997597960915 0.4985018114185785 SGLCS(ph)PSYVAVTPFSLR ddPTM_A459_Selumetinib_30min_R1 1 SGLCSPSYVAVTPFSLR 17 0 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 S(0.356)GLCS(0.642)PS(0.002)YVAVTPFSLR 174.35 2.5991e-07 23420000.0 1359.6 1317.4 1750.7 1917.3 1746.0 1560.8 1259.2 1510.1 998.65 881.29 True False 1391.2760346789266 1163.1581955573556 1512.9645559067421 1582.479547178435 1588.0746082813378 1545.0997690930121 1164.2175302122635 1470.0472425038956 1694.6361114898377 994.4121559915463 1.3990939534439422 1.169694264645779 1.5214662720993568 1.5913718850314296 1.5969983861448676 1.5537820608723 1.1707595519600231 1.4783077958636628 1.7041586843838261 1.0 9.957700122208495 -10.570754461565544 6.351078676773871 0.9999995872172326 1.4599787876456787 0.40964480021230143 0.16739112561869765 1.0330475034661328e-06 1.5455798133410424e-07 0.17110302986249298 0.04149854319223362 2.6868630965386273e-11 10.570754461565544 0.4599792004284461 SGLCS(ph)PSYVAVTPFSLR ddPTM_A459_Selumetinib_30min_R2 1 SGLCSPSYVAVTPFSLR 17 0 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 S(0.023)GLCS(0.786)PS(0.187)Y(0.004)VAVTPFSLR 97.823 0.0054367 9728000.0 40210.0 42174.0 44226.0 42724.0 48885.0 34401.0 25503.0 28537.0 20911.0 50364.0 True False 37975.289173383535 45408.61018921645 41380.54730962796 36904.91749698914 42743.62926255507 39139.425488814275 26688.94003323578 28620.037945445332 25093.784302157354 48909.860458612944 0.7764342162766517 0.9284142249320213 0.8460573577927867 0.7545496378632633 0.8739266246470754 0.8002358853984808 0.5456760616976143 0.5851588550260399 0.513061866602369 1.0 15.577837728176199 -7.138311879990159 5.521925823390448 0.6273904552842747 0.836844765030976 0.26357744340947187 0.13451208065830497 0.2504624508780583 10.265621628830413 0.049027490019032546 0.03781946757982381 7.272573514856019e-08 7.138311879990159 0.20945430974670132 SGLCSPS(ph)YVAVTPFSLR ddPTM_A459_Selumetinib_30min_R2 1 SGLCSPSYVAVTPFSLR 17 0 H0YBT0;A0A087WUS5;P01106;P01106-2;H0YBG3;A0A0B4J1R1 H0YBT0 MYC Myc proto-oncogene protein 1 S(0.151)GLCS(0.162)PS(0.67)Y(0.016)VAVT(0.001)PFSLR 76.32600000000002 0.021118 10499000.0 35719.0 35693.0 43491.0 42652.0 42987.0 25956.0 23543.0 29808.0 21058.0 42617.0 True False 33733.88097448612 38430.53832891597 40692.83640942047 36842.72402119606 37586.58875134407 29531.2033948915 24637.796149569487 29894.736345019966 25270.188409680533 41386.53647773624 0.8150931159130255 0.9285758509796914 0.9832385087674843 0.8902103716993929 0.9081839639217855 0.7135461410446299 0.5953094471392482 0.7223299867361876 0.6105895916966754 1.0 15.336873898098991 -6.768755380149342 6.3185574744467665 0.7017404399549845 0.9104880172018706 0.3749093142686264 0.11143842587568858 0.1349215662489579 21.733908007127212 0.036401622240205836 0.033758854277881584 1.7031175328925633e-07 6.768755380149342 0.20874757724688608 SGLEPAS(ph)SPSK ddPTM_A459_Selumetinib_30min_R2 1 SGLEPASSPSK 11 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SGLEPAS(0.492)S(0.492)PS(0.016)K 122.18 0.0042268 270070000.0 1126600.0 811610.0 1128400.0 1075200.0 1065200.0 894370.0 1247100.0 1062300.0 830850.0 943260.0 True False 1063988.082137128 873857.877262532 1055799.972509028 928755.9051765429 931380.0529911757 1017561.3492174878 1305092.6210817709 1065391.117126767 997043.2158886424 916025.6329161931 1.1615265380182567 0.953966620432423 1.152587803845466 1.0138972882448962 1.0167619982708358 1.1108437500575754 1.4247337347176325 1.1630581927440882 1.0884446679887412 1.0 19.8050284438984 -7.007855974919944 24.78275095312238 1.1948103845122107 1.057213891272203 0.1481380842307385 0.11716983159893472 491.61295045015316 1550861.4199605095 0.041464938955486516 0.035006732719982656 9.820735740841701e-08 7.007855974919944 -0.13759649324000756 SGLEPAS(ph)SPSKGSEPR ddPTM_A459_Selumetinib_30min_R1 2 SGLEPASSPSKGSEPR 16 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SGLEPAS(0.5)S(0.5)PSKGSEPR;SGLEPAS(0.893)S(0.106)PS(0.001)KGSEPR 276.14 7.096899999999998e-51 20770100.0 4448.799999999999 6199.7 4835.4 5203.1 4779.8 4119.3 5436.8 5030.8 3074.8 5191.5 True False 4552.448384142105 5473.836241837666 4178.779238950967 4294.4762592834295 4347.467933942228 4077.863582025148 5026.6977988072085 4897.366841658564 5217.711025493373 5857.87959449229 0.7771495317900387 0.9344398691608974 0.7133603843411102 0.7331110498278579 0.742157271042207 0.6961330488696365 0.8581087606398435 0.8360306426002982 0.8907166733845437 1.0 12.516162824377473 -8.3678205058981 1.0404413251617186 0.9955640114151725 0.7727760806929634 0.5404178627197146 0.06584310088883787 0.41790225526250213 0.9703217366833332 0.06620300618175955 0.022168939543621605 4.287256762976859e-09 8.3678205058981 -0.22278793072220904 SGLEPAS(ph)SPSKGSEPR ddPTM_A459_Selumetinib_30min_R2 1 SGLEPASSPSKGSEPR 16 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 S(0.002)GLEPAS(0.478)S(0.478)PS(0.039)KGS(0.002)EPR 79.51100000000002 0.013509 28826000.0 83920.0 80073.0 86579.0 90461.0 95123.0 59097.0 71982.0 74044.0 60904.0 80418.0 True False 79256.0623583773 86214.34162472462 81008.60140008773 78140.0557460708 83172.79832959034 67237.075320847 75329.30562962712 74259.45578135595 73086.50179994229 78096.12338894325 1.014852708676168 1.1039516160789453 1.0372935029904036 1.0005625420983926 1.0650054666012505 0.8609527900121908 0.9645716376274338 0.9508724960843513 0.9358531336561807 1.0 16.25296331579949 -6.738787630219924 24.999822711059426 0.9407621196605249 1.0448225359485772 0.5986244473830904 0.04170049283193713 159.14382380490798 175640.27036005142 0.013421983067518255 0.013412883113188624 1.824787804488508e-07 6.738787630219924 0.1040604162880523 SGLEPASS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 3 SGLEPASSPSK 11 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SGLEPAS(0.125)S(0.856)PS(0.019)K;SGLEPAS(0.022)S(0.957)PS(0.022)K;SGLEPAS(0.019)S(0.979)PS(0.002)K 140.78 0.001058 254672000.0 38255.0 50296.0 32089.1 34478.0 33522.6 33653.2 37141.0 35316.1 20244.0 36745.6 True False 39146.26706872782 44407.320938023986 27731.57647280917 28457.064532216176 30490.486748895724 33314.67936266081 34339.424467609344 34379.40230513996 34352.5894367399 41462.255692454186 0.944142242503515 1.0710300295144284 0.6688390684411342 0.6863366224765033 0.7353793526106869 0.8034941371683217 0.8282092687460527 0.8291734670720472 0.8285267856999833 1.0 15.339510985813318 -5.252737751066094 24.997870794716857 0.7865167474590218 1.0075861488868565 0.4482657413645369 0.0925934343831261 535.5131536833491 1538403.5571487509 0.02362255393610403 0.06044721637343411 5.588075290747651e-06 5.252737751066094 0.2210694014278347 SGLEPASS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 SGLEPASSPSK 11 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SGLEPAS(0.242)S(0.714)PS(0.044)K;SGLEPAS(0.024)S(0.975)PS(0.001)K;SGLEPAS(0.148)S(0.845)PS(0.007)K 171.49 0.00030256 312724000.0 694030.0 577830.0 622300.0 640640.0 658240.0 536310.0 680450.0 619720.0 495540.0 536810.0 True False 655458.5910222173 622147.7029837075 582261.8955090092 553383.726834357 575546.0064597377 610181.8343625474 712092.2732860958 621523.2825998315 594661.8465444519 521310.90050011803 1.2573276146602825 1.1934292998417106 1.1169187042711328 1.0615234139617453 1.1040360098121664 1.1704758787456224 1.3659646721427698 1.1922315109919532 1.1407048000990674 1.0 18.99178450113277 -7.0018507142461575 24.98128424313409 1.2018124934401004 1.1423044148363135 0.0 0.09796873546312419 211.033287389399 2848605.1890085754 0.03545329257593405 0.030834340905310117 9.957476399615718e-08 7.0018507142461575 -0.05950807860378693 SGLEPASS(ph)PSKGSEPR ddPTM_A459_Selumetinib_30min_R1 2 SGLEPASSPSKGSEPR 16 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SGLEPAS(0.023)S(0.963)PS(0.014)KGSEPR;SGLEPAS(0.005)S(0.994)PS(0.001)KGSEPR 260.58 1.9795e-38 15023900.0 4945.3 7368.900000000001 5394.1 5731.2 5089.8 5759.1 6550.0 5583.2 3205.3999999999996 5767.4 True False 5060.515868121281 6506.145762291334 4661.61084767039 4730.353507948179 4629.428488677175 5701.168682844417 6055.928226564748 5435.1153992104855 5439.329686846769 6507.701969233329 0.7776194871931819 0.9997608669005815 0.7163221164259269 0.7268853936938143 0.7113768440171158 0.8760648090213742 0.9305786059649864 0.8351819774332406 0.8358295620424018 1.0 12.667932466626048 -6.922597493639843 10.60080163850827 0.8890331284465856 0.7911247273669002 0.2712973106955906 0.08919889960214668 0.7036543757045919 91.78985656946826 0.03301418407100856 0.029117619014724583 1.1950952117393512e-07 6.922597493639843 -0.09790840107968535 SGLLSTFGGS(ph)TGR ddPTM_A459_Selumetinib_30min_R1 1 SGLLSTFGGSTGR 13 0 Q9P212-2;Q9P212 Q9P212-2 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 1 SGLLSTFGGS(0.945)T(0.055)GR 97.631 0.013213 10565000.0 1849.9 2091.5 2145.3 2011.2 1716.7 1535.7 1709.2 1675.4 1259.2 2178.5 True False 1892.9990707212016 1846.6262076880282 1853.980043289388 1659.9816748997393 1561.4247881080014 1520.2522523040357 1580.2736679151847 1630.9629495338236 2136.7704316707586 2458.13169538697 0.7700966853296268 0.7512316004685519 0.754223236602271 0.6753021727903873 0.6352079471731457 0.6184584231825345 0.6428759170555388 0.6634969772346027 0.8692660509934065 1.0 11.263346495406036 -8.461726132750425 3.151440355430627 0.9980024263663332 0.6871484244801183 0.7991361262700263 0.05124346079381533 0.10865319247280306 2.2673757197608606 0.057459879456085924 0.015320173526974028 3.453614565305511e-09 8.461726132750425 -0.3108540018862149 SGLLSTFGGS(ph)TGR ddPTM_A459_Selumetinib_30min_R2 2 SGLLSTFGGSTGR 13 0 Q9P212-2;Q9P212 Q9P212-2 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 1 SGLLSTFGGS(0.711)T(0.289)GR;SGLLSTFGGS(0.957)T(0.043)GR 107.46 0.0066084 6320000.0 23003.6 21529.7 22587.5 30676.0 21388.1 20346.8 24448.5 22388.0 17513.2 23345.1 True False 21725.152002706942 23180.95876110338 21134.244841410527 26497.8758809484 18701.135665960006 23149.387010139424 25585.403693783683 22453.14537346708 21016.329359693103 22671.066305145836 0.9582765852427421 1.0224908898899832 0.9322122107954629 1.1687970704286619 0.8248899903625291 1.021098288830156 1.1285487567903392 0.9903877070118535 0.927011066741173 1.0 14.468564627574251 -8.00721647946815 24.99298296698871 0.9619034709042308 1.0091916466993986 0.03539103364374507 0.09229991981064846 1201.5352513343598 4161279.282485164 0.052432276132637845 0.023542218906101437 9.835207354531012e-09 8.00721647946815 0.047288175795167864 SGLNGS(ph)ILAER ddPTM_A459_Selumetinib_30min_R2 2 SGLNGSILAER 11 0 Q96H22-5;Q96H22-4;Q96H22;Q96H22-3 Q96H22-5 CENPN Centromere protein N 1 S(0.487)GLNGS(0.513)ILAER;S(0.116)GLNGS(0.884)ILAER 95.57 0.021092 14705000.0 40116.0 32920.0 44414.0 58219.0 48749.0 48842.0 42557.0 42902.0 38510.0 41111.0 True False 37886.51331707172 35444.85814551632 41556.45159430689 50289.47176662323 42624.71479841053 55569.54215646828 44535.98482509572 43026.837717191556 46213.07605930279 39924.01861079413 0.9489654257106389 0.8878078755311772 1.0408884937016687 1.2596295041558423 1.0676459004276242 1.3918824830285024 1.1155185869253819 1.0777181059012562 1.157525661677963 1.0 15.284969324124164 -5.513397386498809 4.711896682191513 1.1610849270190708 0.924909462955466 0.44609855013813693 0.10441386079213658 0.15831686536719952 9.382512019327535 0.027689619947771887 0.054703633004651656 3.066215067851488e-06 5.513397386498809 -0.2361754640636048 SGLQLS(ph)LEQGTGENSFR ddPTM_A459_Selumetinib_30min_R2 2 SGLQLSLEQGTGENSFR 17 0 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6;C9JBL0 P23497-5 SP100 Nuclear autoantigen Sp-100 1 SGLQLS(0.991)LEQGT(0.009)GENSFR;S(0.007)GLQLS(0.993)LEQGTGENSFR 100.77 0.0062591 0.0 14242.6 13169.2 15225.0 15259.9 17713.9 12816.2 13952.7 11987.5 9610.7 13902.8 True False 13451.053309645185 14179.235294347927 14245.440075726636 13181.475295204204 15488.521517724745 14581.515216119918 14601.528196750543 12022.38164036255 11533.108545394467 13501.390040187518 0.9962717371772459 1.050205590101669 1.055109143082632 0.9763050512553838 1.1471797697587016 1.0800010349095432 1.0814833252937965 0.8904551016286004 0.8542163815033585 1.0 13.720820327629118 -7.764001877696758 24.999914470812826 0.904251765648336 1.0564795277147234 0.5666332883888765 0.05600069149248832 45.861353532476784 447406.9288577603 0.02891749474416192 0.014888863115697412 1.7218611304059194e-08 7.764001877696758 0.15222776206638744 SGLS(ph)DIILGK ddPTM_A459_Selumetinib_30min_R1 2 SGLSDIILGK 10 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;K7EJR2;M0R330;M0QX30;M0R1V5 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 S(0.321)GLS(0.679)DIILGK;S(0.288)GLS(0.712)DIILGK 91.313 0.028206 28364000.0 6557.799999999999 7563.8 8453.6 8557.9 6575.700000000001 7519.0 6433.5 6290.3 3838.7 5870.9 True False 6710.583980742473 6678.226779684781 7305.647552300922 7063.42341667883 5980.929096034131 7443.3656867057725 5948.215915359434 6123.460810225986 6513.993532444842 6624.487202408705 1.0129967461183202 1.0081122622225815 1.1028246155633816 1.0662596516316802 0.9028516341399871 1.1236138676514187 0.8979134133124486 0.9243675205530562 0.9833204191376975 1.0 12.693593065387498 -7.280118448421584 24.98572465032612 0.9450976350382629 1.033182939506226 0.3022266205062498 0.06267009110400847 1032.8807751314175 1381609.5559015127 0.025860430538591987 0.017465089925433955 5.2466434505576854e-08 7.280118448421584 0.08808530446796303 SGLS(ph)DIILGK ddPTM_A459_Selumetinib_30min_R2 1 SGLSDIILGK 10 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;K7EJR2;M0R330;M0QX30;M0R1V5 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 S(0.004)GLS(0.996)DIILGK 95.618 0.022574 1065200.0 10347.0 7176.5 10505.0 12439.0 11621.0 7901.9 6676.0 9757.0 6226.8 8227.0 True False 9771.955162322798 7726.914473915495 9829.11973697919 10744.786741528127 10161.06608694186 8990.31499869368 6986.447228243037 9785.391254641701 7472.333991328659 7989.465133686926 1.2231050513156567 0.9671378927902937 1.2302600452607912 1.344869345035829 1.2718080518429897 1.1252711975407157 0.8744574400588162 1.2247867774505206 0.9352733714078274 1.0 12.963883207739443 -7.004999934136979 23.96603335483747 1.0234334338716138 1.2025444149716653 0.36257764867153663 0.12357965119374487 161.61187123993844 774653.721265897 0.04574788662030006 0.03920017031435339 9.885532445761775e-08 7.004999934136979 0.17911098110005153 SGLS(ph)LEELR ddPTM_A459_Selumetinib_30min_R1 3 SGLSLEELR 9 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 SGLS(1)LEELR;S(0.002)GLS(0.998)LEELR;S(0.001)GLS(0.999)LEELR 111.5 0.010239 45059200.0 5325.3 6641.400000000001 7197.2 6867.0 7692.499999999999 5656.4 6427.599999999999 6153.8 3245.2200000000003 5279.7 True False 5449.3691287699985 5863.821800496904 6219.85977138973 5667.807359554745 6996.714733221179 5599.501751600281 5942.760957109547 5990.581233640473 5506.901318509039 5957.40092363304 0.914722577618089 0.9842919547742863 1.044055931625403 0.9513892773391369 1.1744575903000207 0.9399236048369732 0.9975425581203682 1.005569594934564 0.9243798409912506 1.0 12.540467338098724 -4.809008852843188 3.611827541460703 1.0068679526043691 0.9070532988019224 0.1405237086205633 0.06634783866599105 0.49130907971244686 10.890736145898208 0.01628102546583782 0.12684668245699468 1.5523553657644135e-05 4.809008852843188 -0.0998146538024467 SGLS(ph)LEELR ddPTM_A459_Selumetinib_30min_R2 3 SGLSLEELR 9 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 1 S(0.002)GLS(0.998)LEELR;SGLS(1)LEELR;S(0.001)GLS(0.999)LEELR 111.5 0.010239 22307200.0 168713.0 140755.0 160175.0 160109.0 160056.0 118835.7 109692.8 121965.5 114922.4 130476.0 True False 159336.6068716503 151550.4559013413 149869.5148853538 138301.87799656962 139948.33436120534 135204.23899192124 114793.73255215953 122320.39941252446 137910.09120014615 126708.81886263945 1.257502108392167 1.1960529445518058 1.1827867723068435 1.091493703737368 1.1044877193032505 1.067046794418401 0.9059648222007606 0.9653661087720159 1.0884016790468989 1.0 16.951157413174663 -5.987647059471502 0.7474713493740189 0.9892541955312633 1.2558168855232612 0.7613695085718568 0.0502916884618941 0.4227345068155595 0.46332146276426167 0.028261672529915714 0.07236850432805103 1.0288520814523441e-06 5.987647059471502 0.26656268999199795 SGLSCQVGSATSHPVSCQEPIDEDQRIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SGLSCQVGSATSHPVSCQEPIDEDQRISPK 30 1 Q8TEP8-1;H0Y966;A0A0A0MR42;K7ENP4;Q8TEP8;Q8TEP8-2;K7ELX0 Q8TEP8-1 CEP192 Centrosomal protein of 192 kDa 1 SGLSCQVGSATSHPVS(0.003)CQEPIDEDQRIS(0.997)PK 64.422 0.00024224 11494000.0 16863.0 11460.0 11221.0 17228.0 16683.0 10159.0 12478.0 11459.0 10028.0 17057.0 True False 15925.821967937509 12338.945150292138 10499.053076501055 14881.516680042334 14587.132392087686 11558.310035779894 13058.25172468793 11492.343792860434 12033.880205730671 16564.520090591705 0.9614417973378557 0.7449020607183421 0.6338277848728195 0.8983970920168535 0.8806251139369179 0.6977751225249664 0.78832659523319 0.6937927407500228 0.7264852914492621 1.0 14.01580878562742 -6.76335687852627 24.999921635550436 0.7625786751732573 0.813039352604575 0.015688020028638894 0.11743173930802957 206.8915178359932 2697378.8116807677 0.0401858746712423 0.0372299300526443 1.7244202790186586e-07 6.76335687852627 0.05046067743131777 SGLTVPT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 SGLTVPTSPK 10 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 1 SGLTVPT(0.619)S(0.381)PK;SGLTVPT(0.64)S(0.36)PK 144.7 0.0022266 40946000.0 14573.5 18955.4 19426.5 21725.0 16388.0 16778.2 17547.300000000003 17631.7 11167.2 19358.5 True False 14913.034194905362 16736.092955873606 16788.488002126185 17931.136578757378 14905.708293536387 16609.42654138671 16223.693033587731 17164.050040166843 18949.92277998229 21843.35204275817 0.6827264499383258 0.766187026749047 0.7685856991757889 0.8208967444033926 0.6823910663692364 0.7603881725146352 0.742729092212129 0.7857791243106078 0.867537305761862 1.0 14.414906646264399 -8.529043274186206 1.4935563929683193 0.9993984461690478 0.7481861500004202 0.8084549518136698 0.03871656055034448 0.17846135919930198 0.8808974982324799 0.03671776217203261 0.010844521336819238 2.9577177374899885e-09 8.529043274186206 -0.2512122961686276 SGLTVPT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 3 SGLTVPTSPK 10 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 1 SGLTVPT(0.923)S(0.077)PK;SGLTVPT(0.713)S(0.287)PK;SGLTVPT(0.636)S(0.364)PK 136.81 0.0042453000000000005 248080000.0 1079070.0 967320.0 952570.0 911940.0 837470.0 585195.0 814960.0 831060.0 513916.0 726110.0 True False 1019099.6092594618 1041510.3335759694 891282.6832797987 787732.1988157536 732259.5315232079 665800.2993787001 852857.2548126039 833478.2470106108 616713.5600127921 705145.3176396533 1.445233462899128 1.4770151733577943 1.2639702214335147 1.1171203709506927 1.038451951966886 0.9442029645851531 1.209477299895275 1.1819950103342227 0.874590732697665 1.0 19.427561075826496 -5.5593054540538605 1.9360963235156057 1.055097390910494 1.4712777272627442 0.7518086418035655 0.09525792271289478 0.17566023798637098 1.2979888710438048 0.029069107291844323 0.07361783902894829 2.758636930729058e-06 5.5593054540538605 0.41618033635225027 SGLTVPTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SGLTVPTSPK 10 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 1 SGLTVPT(0.076)S(0.924)PK 84.65799999999999 0.037561 12710000.0 176200.0 149580.0 156470.0 161330.0 150410.0 111440.0 143320.0 139890.0 91736.0 126230.0 True False 166407.50938448595 161052.30502449366 146402.89055165488 139356.57569022712 131514.15111753927 126789.84844840167 149984.66398319244 140297.05673996368 110085.76331800057 122585.41191507224 1.3574821570104432 1.3137966623310078 1.1942929282081582 1.1368120685255276 1.072836882162234 1.034298016930777 1.2235115226198574 1.1444841155908678 0.8980331476494814 1.0 16.903427778016777 -1.5228787452875598 0.30594989972275166 1.0263686650541168 4.228279800922742 0.6627997283406393 0.07817294608201643 36.24207576760854 0.5171940776261211 0.08206715835423944 63.938610637072955 0.029999999999501103 1.5228787452875598 3.201911135868625 SGMS(ph)PEQSR ddPTM_A459_Selumetinib_30min_R1 2 SGMSPEQSR 9 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.121)GMS(0.866)PEQS(0.014)R;S(0.011)GMS(0.987)PEQS(0.002)R 106.16 0.013330000000000002 310079000.0 5814.4 7607.9 7670.7 8485.099999999999 7552.3 6425.1 7251.8 6712.1 3988.6 5799.0 True False 5949.864207147064 6717.163531183244 6629.061072139054 7003.336570053581 6869.195798466863 6360.469327524038 6704.790887542323 6534.073304026488 6768.3628841820155 6543.358137043394 0.9092982658955453 1.026562109317523 1.0130976989644624 1.0702969978681356 1.049796702946585 0.9720497020506974 1.0246712387000525 0.9985810293701727 1.0343867388008032 1.0 12.67581552042326 -4.759959008351298 24.984153565365173 1.02177563181436 0.9092981273017596 0.6198559762390821 0.026248774701311962 25.692286056486303 433458.1206831835 0.006744446918180159 0.04130530034853254 1.7379648618789603e-05 4.759959008351298 -0.11247750451260041 SGMS(ph)PEQSR ddPTM_A459_Selumetinib_30min_R2 3 SGMSPEQSR 9 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.045)GMS(0.955)PEQSR;S(0.012)GMS(0.987)PEQS(0.001)R;S(0.004)GMS(0.957)PEQS(0.039)R 106.67 0.013035 362263500.0 221020.8 188306.8 212712.1 224361.3 245826.7 163298.8 190521.5 196112.6 161634.3 220687.1 True False 208737.34875236452 202749.32605820475 199026.43506942326 193802.90389516996 214943.7522274183 185791.727421086 199381.12726119 196683.25519781132 193965.67643968188 214315.29000905287 0.9739731996888662 0.9460329500972163 0.9286618563753254 0.9042887415404824 1.0029324189531175 0.8669084105629513 0.9303168581801512 0.9177285259931909 0.90504824192193 1.0 17.70937525507815 -6.765904718362523 24.999999405276714 0.9192532344994395 0.9470361652856357 0.09553763303305618 0.03949999575728685 268.7885455150938 1504847.0229700804 0.013091241237848881 0.01192216534569041 1.7143333808444151e-07 6.765904718362523 0.027782930786196203 SGNS(ph)DSIER ddPTM_A459_Selumetinib_30min_R2 1 SGNSDSIER 9 0 A0A5F9ZI51;A0A5F9ZGW5;C9J8U3;A0A0A0MRW7;Q7Z2E3-13;Q7Z2E3-4;Q7Z2E3-5;Q7Z2E3-9;Q7Z2E3-10;Q7Z2E3-11;Q7Z2E3-8;Q7Z2E3-7;Q7Z2E3 A0A5F9ZI51 APTX Aprataxin 1 SGNS(0.997)DS(0.003)IER 128.57 0.0042932 58008000.0 43362.0 34371.0 35019.0 42584.0 44359.0 30448.0 47659.0 56853.0 40048.0 46788.0 True False 40952.11363183926 37007.14517981599 32765.915665804314 36783.98573850259 38786.225845508445 34641.93562057547 49875.237934516896 57018.43281747919 48058.71903461328 45437.10887017672 0.9012922399804965 0.8144696284605851 0.7211267723794521 0.8095582367179676 0.8536244230751733 0.7624150497681242 1.0976763085217598 1.2548869026942873 1.0576975566805327 1.0 15.471583419687924 -7.293829952221436 7.013587218599245 1.1253444109507738 0.8084190002454691 0.7771386675717736 0.07627050228347165 0.09361510927916158 15.939838409479737 0.031179425560730563 0.021274791223435525 5.0835845108436145e-08 7.293829952221436 -0.31692541070530467 SGNTPNS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SGNTPNSPR 9 0 Q96EA4-2;Q96EA4-3;Q96EA4 Q96EA4-2 SPDL1 Protein Spindly 1 SGNTPNS(1)PR 80.834 0.045404 3597600.0 9504.5 7702.8 9993.7 8724.1 8521.1 12052.0 17957.0 60748.0 13014.0 29914.0 True False 8976.277939528078 8293.579991594263 9350.716222317846 7535.862530088078 7450.603238399468 13712.053602836811 18792.036081120474 60924.76662262722 15617.16364154157 29050.305094093943 0.3089908319535341 0.2854902888190453 0.3218801383335175 0.25940734548843525 0.2564724609351593 0.4720106573209289 0.6468791298491725 2.0972160679652725 0.5375903485680297 1.0 14.826265694828995 -7.534606771473123 24.903573491030055 1.2648517367404146 0.33145390183005885 0.5454981524166316 0.3640280172641428 144.25449410738335 306309.1791543958 0.15809118967499827 0.09136336513416858 2.920069771623573e-08 7.534606771473123 -0.9333978349103558 SGPEAEGLGSETSPTVDDEEEMLYGDSGS(ph)LFSPSKEEARR ddPTM_A459_Selumetinib_30min_R1 1 SGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEARR 40 2 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 SGPEAEGLGSETSPT(0.016)VDDEEEMLY(0.042)GDS(0.275)GS(0.333)LFS(0.267)PS(0.068)KEEARR 81.077 2.1965e-09 13449000.0 557.94 368.95 1552.2 1596.5 708.74 670.56 519.13 532.98 314.81 254.35 True False 570.9389164377467 325.7531624797984 1341.4197656242898 1317.701245016623 644.6345921382098 663.814775219766 479.97160614603905 518.8436390369691 534.2095771873187 286.9983000788044 1.9893459866521073 1.1350351635893057 4.673964149808416 4.59132073135906 2.2461268654246562 2.312957167472751 1.6723848399598458 1.8078282655141311 1.8613684368187362 1.0 8.164898381466134 -6.787566449922918 2.274597692592925 1.6917580203972573 3.0663128117154685 0.27479153634338893 1.0378481442003427 0.4722127038685631 5.01476322548952 0.44973753991246423 0.40810551479450125 1.630923348096557e-07 6.787566449922918 1.3745547913182112 SGPEAEGLGSETSPTVDDEEEMLYGDSGSLFS(ph)PSKEEAR ddPTM_A459_Selumetinib_30min_R1 2 SGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEAR 39 1 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 SGPEAEGLGSETS(0.001)PT(0.078)VDDEEEMLY(0.069)GDS(0.019)GS(0.077)LFS(0.715)PS(0.041)KEEAR;SGPEAEGLGSETSPT(0.002)VDDEEEMLY(0.001)GDS(0.277)GS(0.277)LFS(0.421)PS(0.023)KEEAR 123.04 1.6702999999999996e-24 14319600.0 4815.7 6364.5 5318.0 5963.5 5458.6 4843.1 4642.8 5187.0 2757.3 4813.2 True False 4927.896440278986 5619.34138122422 4595.844809683013 4922.086673759244 4964.870593794103 4794.382811182963 4292.589858060277 5049.423910249459 4678.936714775877 5431.021104538241 0.9073609447330564 1.0346749300106044 0.8462211288117916 0.9062912073102195 0.9141689008804227 0.8827774223113783 0.7903835716037497 0.9297374863872443 0.8615206283890313 1.0 12.40700775413917 -5.271376402981221 24.978341671650515 0.8863092727355143 0.9710179409295339 0.2186067795601252 0.059604705216907236 794.1296170994123 1996177.8588179136 0.014713303171662006 0.031236735274062972 5.353324837860437e-06 5.271376402981221 0.08470866819401957 SGPIS(ph)PGIHSCDLTVEGLATVTR ddPTM_A459_Selumetinib_30min_R1 2 SGPISPGIHSCDLTVEGLATVTR 23 0 Q9BUB4-2;Q9BUB4 Q9BUB4-2 ADAT1 tRNA-specific adenosine deaminase 1 1 S(0.013)GPIS(0.987)PGIHSCDLTVEGLATVTR;S(0.002)GPIS(0.998)PGIHSCDLTVEGLATVTR 174.98 1.1594e-13 29571000.0 4258.7 4682.8 5609.6 5164.3 4996.9 4661.9 4993.5 5397.1 2484.7 3831.4 True False 4357.919424012316 4134.535599025342 4847.847131327157 4262.451950917221 4544.931277274347 4615.0055186665295 4616.836274710085 5253.951375748479 4216.3544246921365 4323.197510996393 1.0080315352068938 0.9563605614846015 1.1213568473326225 0.9859489278653911 1.0512892981905075 1.067498190153908 1.0679216628356207 1.2152929313048133 0.9752860964523381 1.0 12.077883033832707 -6.643240342557462 2.3118987307138403 1.0805086634130423 1.0203368646937452 0.06763628532582044 0.07193271521853815 0.652461498754094 7.115094322185554 0.02604547878748161 0.02590902605196401 2.2738387192690625e-07 6.643240342557462 -0.06017179871929712 SGPIS(ph)PGIHSCDLTVEGLATVTR ddPTM_A459_Selumetinib_30min_R2 3 SGPISPGIHSCDLTVEGLATVTR 23 0 Q9BUB4-2;Q9BUB4 Q9BUB4-2 ADAT1 tRNA-specific adenosine deaminase 1 1 S(0.158)GPIS(0.838)PGIHS(0.004)CDLTVEGLATVTR;S(0.084)GPIS(0.916)PGIHSCDLTVEGLATVTR;S(0.019)GPIS(0.975)PGIHS(0.007)CDLTVEGLATVTR 109.28 1.1256e-05 15517500.0 71231.1 61370.9 69725.0 90353.5 78211.3 55480.2 59165.5 74381.4 67564.5 70646.0 True False 67272.36062268598 66077.85069145408 65238.96941083995 78047.1974315188 68385.69727610666 63122.09395088846 61916.812984214135 74597.83755949643 81079.28790986128 68606.26641964843 0.9805570851385025 0.9631459943800378 0.9509185212293654 1.137610330725803 0.9967850000436899 0.9200630969303216 0.9024950083347129 1.087332709569108 1.1818058632416797 1.0 16.06605273611754 -7.895840906571235 7.873877679739328 1.105098292724996 0.981868495663145 0.3241074554839929 0.07270711676529845 0.2666801601966185 17.828670687806127 0.04146153501321716 0.019819828406940954 1.2710396350009454e-08 7.895840906571235 -0.12322979706185089 SGPKPFSAPKPQT(ph)SPSPK ddPTM_A459_Selumetinib_30min_R2 1 SGPKPFSAPKPQTSPSPK 18 2 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 SGPKPFSAPKPQT(0.509)S(0.361)PS(0.13)PK 98.077 0.010917 580560000.0 47280.0 43774.0 51623.0 43271.0 38199.0 35844.0 32765.0 31308.0 24626.0 36981.0 True False 44652.366876835986 47131.32504440559 48301.63238287265 37377.41515336152 33400.10011660719 40781.18564056449 34288.63742261581 31399.101096681574 29551.888107930135 35913.2624418228 1.2433391967429854 1.3123654560973215 1.344952507757217 1.040769136858857 0.93002133044062 1.1355466718354372 0.9547625331494519 0.8743037797678815 0.8228683806101524 1.0 15.1322290961791 -5.868778691501492 4.179555574431194 0.9579900474784172 1.3013139243988372 0.7846891453173971 0.08123769421457637 0.10458570954953582 3.2866122633815835 0.025389321817253677 0.03927810559973834 1.3527617301399325e-06 5.868778691501492 0.34332387692042 SGPKPFSAPKPQTS(ph)PSPK ddPTM_A459_Selumetinib_30min_R2 1 SGPKPFSAPKPQTSPSPK 18 2 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 SGPKPFSAPKPQT(0.161)S(0.775)PS(0.064)PK 66.068 0.036342 7264600.0 11353.0 135340.0 0.0 47109.0 12192.0 13055.0 10809.0 9711.8 11611.0 25844.0 True False 10722.04570965987 145720.14281331078 0.0 40692.67293244221 10660.331962137085 14853.20774850935 11311.639917627173 9740.059730124956 13933.524438446226 25097.816569223887 0.42721029855671755 5.806088446434804 0.0 1.621363070377264 0.42475136961552584 0.5918127462419598 0.4507021511782835 0.38808394759202564 0.5551687892855255 1.0 14.61527423927251 -5.302535671363591 24.99958276915793 0.6275840088086523 3.1166560383687782 0.3804744056700736 1.2697495579397864 397.32749798025793 241700.46405928026 0.3002353037063707 0.6249992756978265 4.9826952824933325e-06 5.302535671363591 2.489072029560126 SGPKPFSAPKPQTSPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SGPKPFSAPKPQTSPSPK 18 2 Q01518-2;Q01518 Q01518-2 CAP1 Adenylyl cyclase-associated protein 1 1 SGPKPFSAPKPQT(0.161)S(0.161)PS(0.678)PK;SGPKPFSAPKPQT(0.015)S(0.172)PS(0.813)PK 98.887 0.0035754 3226250000.0 132751.0 134103.0 131813.0 124599.0 118245.0 86053.0 116827.0 117189.0 58905.0 112567.0 True False 125373.230864358 144388.26889089242 123332.29508714308 107628.401254736 103390.00597628772 97906.0196386424 122259.6869883088 117530.00058831679 70687.64594321558 109316.89822580991 1.1468787799428906 1.3208229581545343 1.1282088779392765 0.9845541082991024 0.9457824696299072 0.8956165170036504 1.1183969630730253 1.0751311324763488 0.6466305492605543 1.0 16.7381569047442 -5.645075507133968 2.9208467892752825 0.9575996945108706 1.234310581681671 0.45884280182480186 0.1258512869580403 0.2306792310290936 3.9292854500792638 0.03567367172793505 0.06885643438129058 2.2642506071335315e-06 5.645075507133968 0.2767108871708005 SGPPPEHLPSS(ph)PLPPHPPSQPCTPELPAGPR ddPTM_A459_Selumetinib_30min_R1 1 SGPPPEHLPSSPLPPHPPSQPCTPELPAGPR 31 0 A0A494BYR6;Q86Y91-6 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 1 S(0.005)GPPPEHLPS(0.473)S(0.523)PLPPHPPSQPCTPELPAGPR 58.867 0.001194 9495000.0 1111.8 1183.5 1406.8 1698.7 1416.5 1226.1 1333.2 1110.0 407.14 778.62 True False 1137.702776813792 1044.9352698057767 1215.7642869992596 1402.0539335482238 1288.3778251033864 1213.7665472097283 1232.6356506345226 1080.5591942118572 690.8868436709288 878.5634614010572 1.2949579931306063 1.1893680032395202 1.3838092982611223 1.5958482171707313 1.46645960332654 1.381535427473979 1.40301265052478 1.2299159271757951 0.7863824003893379 1.0 9.779002690170977 -8.078882115632345 3.702345489119734 0.898926554023617 1.3886586008553614 0.7548269903975422 0.1110811048705927 0.12583298817306354 3.1697403576445047 0.0920013330019162 0.03220271963667194 8.33907508744866e-09 8.078882115632345 0.4897320468317444 SGPPS(ph)PPSTATSFGGPRPR ddPTM_A459_Selumetinib_30min_R1 5 SGPPSPPSTATSFGGPRPR 19 1 A0A087X0E3;A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A087X0E3;A0A0A0MS59 SRCAP Helicase SRCAP 1 S(0.003)GPPS(0.99)PPS(0.006)T(0.001)ATSFGGPRPR;SGPPS(0.995)PPS(0.005)TATSFGGPRPR;SGPPS(0.977)PPS(0.014)T(0.004)AT(0.004)S(0.001)FGGPRPR;SGPPS(1)PPSTATSFGGPRPR;SGPPS(0.786)PPS(0.102)T(0.102)AT(0.005)S(0.005)FGGPRPR 145.88 2.6838000000000006e-05 127638000.0 7033.5 6739.700000000001 8947.5 9780.9 7361.63 6759.1900000000005 6570.45 6500.11 4044.7000000000003 5689.49 True False 7197.366865191408 5950.612790798477 7732.478645099432 8072.849425232122 6695.771866301343 6691.198685453485 6074.835666600353 6327.705967467055 6863.560486800133 6419.791461825664 1.121121598417874 0.9269168361905387 1.2044750504871486 1.2574940281528024 1.0429889983369016 1.0422766417323217 0.946266822329582 0.9856559991229963 1.069125146449581 1.0 12.648310718789048 -6.5072557408801455 22.99788745722832 1.0081756213849768 1.1226185984827826 0.30357858285218164 0.08513382336465211 348.2579805883316 512655.28882437496 0.028832219504660743 0.03165701790151477 3.109884495241683e-07 6.5072557408801455 0.11444297709780571 SGPPS(ph)PPSTATSFGGPRPR ddPTM_A459_Selumetinib_30min_R2 2 SGPPSPPSTATSFGGPRPR 19 1 A0A087X0E3;A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A087X0E3;A0A0A0MS59 SRCAP Helicase SRCAP 1 S(0.423)GPPS(0.572)PPS(0.002)T(0.001)AT(0.001)S(0.001)FGGPRPR;SGPPS(0.908)PPS(0.062)T(0.006)AT(0.006)S(0.018)FGGPRPR 106.31 0.0039274 12732400.0 34601.0 30353.1 34264.7 37741.0 41678.0 28112.8 28829.8 30691.2 25779.0 28953.3 True False 32678.014938777524 32681.08516940072 32060.14650658456 32600.61069314359 36442.037033952554 31985.08301741047 30170.44282516495 30780.50631079834 30935.520325441852 28117.34299929231 1.1622013836655904 1.162310577148889 1.1402267457274142 1.1594484832355647 1.2960697258937224 1.137557094858341 1.0730189842590858 1.0947160374140992 1.1002291477619517 1.0 14.779172650245332 -7.929471591008662 0.7950931675351113 1.0200831647180977 1.1782488988565765 0.5486432682643281 0.04886414558536774 0.5167124237759041 0.6347381850280504 0.049222132486772 0.020934942297278495 1.1763279306243887e-08 7.929471591008662 0.1581657341384788 SGPS(ph)PLSSPNGK ddPTM_A459_Selumetinib_30min_R1 2 SGPSPLSSPNGK 12 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 S(0.071)GPS(0.928)PLS(0.001)SPNGK;S(0.079)GPS(0.92)PLS(0.001)SPNGK 103.97 0.010202 4169400.0 5236.700000000001 5214.9 5775.700000000001 6555.299999999999 6422.9 4677.1 5663.6 5634.0 2684.4 4558.700000000001 True False 5358.70492115559 4604.337083658764 4991.3916636491485 5410.5399132210905 5841.949829055095 4630.052620467026 5236.390092209483 5484.568018188828 4555.2307391812155 5143.8535504983165 1.0417685629165043 0.8951143415062262 0.9703603756692494 1.0518456367594171 1.1357146488918117 0.9001136161853761 1.0179897310066695 1.066237202195911 0.8855677352517011 1.0 12.328633853265453 -5.562671251311954 14.722032734253913 1.0121074880383327 0.959518147122479 0.04731718318136868 0.07709538749119822 5.908941458425081 2183.7840738310697 0.020697251844655967 0.03585709976494528 2.7373400315366747e-06 5.562671251311954 -0.052589340915853766 SGPS(ph)PLSSPNGK ddPTM_A459_Selumetinib_30min_R2 1 SGPSPLSSPNGK 12 0 O75179-4;O75179-6;O75179-2;O75179;H0YM23;O75179-7 O75179-4 ANKRD17 Ankyrin repeat domain-containing protein 17 1 S(0.067)GPS(0.933)PLSSPNGK 135.91 0.0014508 17543000.0 126980.0 101790.0 147950.0 153410.0 148940.0 102350.0 93502.0 113710.0 93044.0 123920.0 True False 119922.9599412148 109596.96569356328 138431.05807578017 132515.29335298907 130228.82565950608 116447.78345920586 97850.02827069811 114040.87727429617 111655.39986657407 120342.10761717323 0.9965170322819025 0.9107117023594775 1.1503127277457252 1.1011548324759328 1.0821551013032282 0.9676395549730955 0.8130988413629426 0.9476390228853043 0.927816556294386 1.0 16.876782003246063 -6.955335585252137 5.668870860963382 0.9139752332181854 1.0479972033591065 0.3924637368169872 0.07412184539306531 0.19764704751285586 15.13973923122447 0.02820358992784159 0.024541383232342343 1.1083180718502515e-07 6.955335585252137 0.1340219701409211 SGQGFHGNSEVNAILS(ph)PR ddPTM_A459_Selumetinib_30min_R1 6 SGQGFHGNSEVNAILSPR 18 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59 Q8TB72-3 PUM2 Pumilio homolog 2 1 SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNS(0.002)EVNAILS(0.998)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR 289.68 1.0279999999999996e-80 160323600.0 16636.68 19829.489999999998 18136.17 16893.3 16536.809999999998 17197.07 17828.94 17545.739999999998 11490.730000000001 18065.93 True False 17024.28227465594 17507.84409232019 15673.377728850845 13943.202281515389 15041.058455310938 17024.083089490254 16484.088701638062 17080.36997860427 19498.929560286022 20384.868092560177 0.8351431168136554 0.858864723226244 0.7688731493225176 0.6839976701445623 0.73785409780505 0.8351333455870386 0.8086433832581054 0.8378945549732577 0.9565394032352118 1.0 14.315211000941767 -8.225574347930484 1.3937056431886823 1.0044232675350901 0.7834065669736265 0.7061895458537117 0.0484235807605203 0.24914279464910757 0.9208916851490798 0.05139279578352796 0.01611875416762826 5.948749099563223e-09 8.225574347930484 -0.2210167005614636 SGQGFHGNSEVNAILS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 SGQGFHGNSEVNAILSPR 18 0 Q8TB72-3;Q8TB72;C9JW01;Q8TB72-2;Q8TB72-4;A0A0A0MR59 Q8TB72-3 PUM2 Pumilio homolog 2 1 SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR;SGQGFHGNSEVNAILS(1)PR 161.64 6.4576e-06 136761000.0 108467.6 94786.0 140629.0 176012.0 188676.0 127646.3 122819.9 117716.0 119480.0 151113.0 True False 102439.40502220597 102055.78141497297 131581.08324527802 152038.86196236438 164972.8340951589 145228.41916725758 128531.26871301471 118058.53407106717 143379.33855012973 146749.9750512745 0.6980539859472794 0.6954398553002454 0.8966344505292321 1.0360401213645314 1.1241762326536502 0.989631644683515 0.8758520651748379 0.8044875921090786 0.9770314339067719 1.0 17.163000732501914 -5.346979484863356 3.4778618959038377 0.9672694112514112 0.6923934623036906 0.6385304000423644 0.08158183882464987 0.1692452957961925 3.8643344671209836 0.025445978468855653 0.061556512968710515 4.498011020274553e-06 5.346979484863356 -0.2748759489477206 SGRS(ph)PTGNTPPVIDSVSEK ddPTM_A459_Selumetinib_30min_R1 2 SGRSPTGNTPPVIDSVSEK 19 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.064)GRS(0.932)PT(0.004)GNTPPVIDSVSEK;S(0.001)GRS(0.982)PT(0.017)GNTPPVIDSVSEK 192.25 1.4453e-14 16300200.0 4175.6 4682.9 6308.9 7227.0 5553.8 5054.7 5001.5 4762.1 2516.7 4075.7 True False 4272.883355696771 4134.623890978855 5452.186032307097 5964.940117591688 5051.459770603031 5003.854307300391 4624.232828269247 4635.793638519173 4270.656087504608 4598.855795679907 0.9291187950947822 0.899054911628857 1.1855527275781934 1.2970487405139035 1.0984166486255762 1.08806506000926 1.0055181187923263 1.0080319637058341 0.9286344858902502 1.0 12.167059245128533 -7.410316879706081 2.302209455260343 0.9758080080259409 1.090424075256119 0.16223229184988708 0.10876258470334578 0.6493037077672265 6.7284230559857505 0.06505751508490032 0.03793131409171154 3.8876138466132575e-08 7.410316879706081 0.11461606723017803 SGS(ph)AAQAEGLCK ddPTM_A459_Selumetinib_30min_R1 1 SGSAAQAEGLCK 12 0 F8WF93;H7BZZ2;F8WE30;H7C0X4;Q92685 F8WF93 ALG3 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase 1 S(0.12)GS(0.88)AAQAEGLCK 118.21 0.0045774 9563100.0 1951.1 2384.0 2293.0 1846.1 2321.8 2173.0 2574.8 2318.9 1197.7 2427.3 True False 1996.5568338202802 2104.880171708469 1981.6231945474137 1523.713290588905 2111.7935999470824 2151.1415929261384 2380.580763016627 2257.395239151238 2032.4094234530412 2738.867598904198 0.7289716504073029 0.7685220609242362 0.7235191636646647 0.5563296638357152 0.7710462531273861 0.7854127719743719 0.8691843168939896 0.8242075082615918 0.7420619471588163 1.0 11.419363810281423 -6.757313733941108 2.518324507128686 0.8410366100039297 0.7001914588077265 0.42953515806356946 0.08124789822107865 0.3049044479161537 3.9650655119925315 0.030840530422095867 0.028622059098282974 1.7485830574366913e-07 6.757313733941108 -0.14084515119620322 SGS(ph)AAQAEGLCK ddPTM_A459_Selumetinib_30min_R2 4 SGSAAQAEGLCK 12 0 F8WF93;H7BZZ2;F8WE30;H7C0X4;Q92685 F8WF93 ALG3 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase 1 S(0.126)GS(0.874)AAQAEGLCK;S(0.014)GS(0.986)AAQAEGLCK;S(0.025)GS(0.975)AAQAEGLCK;S(0.005)GS(0.995)AAQAEGLCK 135.47 0.0014878 42995500.0 229395.0 77030.0 161290.0 174651.0 82366.0 92380.0 252410.0 172233.0 152545.0 128397.0 True False 216646.14424094287 82937.95330951178 150912.77699927374 150863.23251022 72018.44671861749 105104.50645785485 264147.56514092634 172734.16951529187 183058.26246342118 124689.84499453058 1.7374802595227052 0.6651540332987805 1.2103052739049713 1.2099079320921242 0.5775806900856804 0.8429275572719268 2.118436871523202 1.385310644366177 1.4681088301252672 1.0 16.927984448244317 -7.220716701976349 24.999234319375383 1.5250742051034119 1.0178642869935968 0.2332302047611955 0.3988959899900214 668.000683709222 410079.2254898264 0.14797779464580046 0.1146218976694271 6.015660217499134e-08 7.220716701976349 -0.5072099181098151 SGS(ph)DAGEARPPTPASPR ddPTM_A459_Selumetinib_30min_R1 1 SGSDAGEARPPTPASPR 17 1 Q96FS4;F6RY50;E9PIB3 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 S(0.006)GS(0.994)DAGEARPPTPASPR 203.05 1.4286e-07 10989000.0 1993.0 2182.8 2224.3 3084.1 2367.7 2040.1 2054.1 2074.4 1108.6 1543.4 True False 2039.4330222970727 1927.2367612438104 1922.2522772053255 2545.51983072707 2153.541953051387 2019.578446262593 1899.1575832346027 2019.380173399167 1881.2132310595641 1741.5104239890973 1.1710713838999338 1.1066466985763364 1.1037845371044186 1.4616736114024007 1.2365943513094177 1.1596706045758567 1.0905232360794026 1.1595567534838995 1.080219334404249 1.0 10.766123393011569 -7.040440285683782 3.360917079071283 1.0963709477636128 1.216656193810931 0.2762903127411259 0.10055094557805538 0.41119714399375584 9.43219368132753 0.043278621014280635 0.03428111687091351 9.110867156123569e-08 7.040440285683782 0.12028524604731827 SGS(ph)ESEEAELSLSLAR ddPTM_A459_Selumetinib_30min_R1 1 SGSESEEAELSLSLAR 16 0 Q8IV50 Q8IV50 LYSMD2 LysM and putative peptidoglycan-binding domain-containing protein 2 1 S(0.012)GS(0.985)ES(0.003)EEAELSLSLAR 183.76 8.5417e-07 6117400.0 910.2 1167.1 1391.6 1545.7 1396.1 1065.5 1254.3 1406.3 722.09 843.34 True False 931.4058890591051 1030.4553894299304 1202.6283635116354 1275.7725113825209 1269.8230015014738 1054.782037396595 1159.6871411572765 1369.000355693814 1225.3339906330523 951.5909038272423 0.9787881381726599 1.0828764601316594 1.2638081749990835 1.3406732937982482 1.3344211219278377 1.1084406472932056 1.2186824574437223 1.4386438018562133 1.2876688771454534 1.0 9.894197671010188 -5.1080690202251695 2.860596023849201 1.2655664392789279 0.9880582459539828 0.3621791586868587 0.11782514653843106 0.2816104330220253 4.224601985299959 0.031042080008516597 0.12451979162964404 7.797061859161097e-06 5.1080690202251695 -0.27750819332494503 SGS(ph)FDSR ddPTM_A459_Selumetinib_30min_R2 1 SGSFDSR 7 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 S(0.004)GS(0.987)FDS(0.009)R 90.709 0.029294 17084000.0 53238.0 35243.0 39373.0 43277.0 41016.0 41373.0 78875.0 156860.0 43815.0 95744.0 True False 50279.24508859972 37946.02477589406 36839.78404608109 37382.59794301093 35863.20339230767 47071.75520329968 82542.84378784747 157316.436630429 52579.22429338746 92979.62194721305 0.5407555336925821 0.40811119663873235 0.39621352802440946 0.4020515158067001 0.38571035933731956 0.5062588362643972 0.887751983275531 1.6919453245329568 0.5654919130907852 1.0 16.50462693945677 -7.337489306194154 3.5162878756482163 1.1230380879365112 0.42796044070995654 0.5594965779179587 0.2613492570064518 0.1611622651475683 3.870135559952281 0.10960205505477025 0.07175422876730274 4.5973830871081904e-08 7.337489306194154 -0.6950776472265546 SGS(ph)GGGSAKEPQEER ddPTM_A459_Selumetinib_30min_R1 1 SGSGGGSAKEPQEER 15 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 S(0.015)GS(0.982)GGGS(0.003)AKEPQEER 147.09 0.0015702 4340600.0 668.05 524.11 1063.6 1284.4 712.78 628.93 745.34 711.5 349.48 561.05 True False 683.6142652009831 462.74695754787143 919.1689619366019 1060.1036511740372 648.3091748515297 622.6035352227501 689.1184037233231 692.6287087222848 593.0420349907064 633.0662325897907 1.0798463573146322 0.7309613650610213 1.4519317483992198 1.67455409339603 1.024077958161474 0.9834729814537112 1.0885407691138893 1.0940856944601702 0.9367772350843124 1.0 9.306212634815658 -6.425349603104895 21.076373412929506 1.0271789117846655 1.2308362807446294 0.1683011977653026 0.23184661735090525 27.42559452296148 5917.457198850952 0.07929715436586256 0.08991435546597489 3.755349803395353e-07 6.425349603104895 0.2036573689599639 SGS(ph)GGGSAKEPQEER ddPTM_A459_Selumetinib_30min_R2 1 SGSGGGSAKEPQEER 15 1 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;F6UYG0 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 S(0.026)GS(0.974)GGGSAKEPQEER 103.39 0.042387 0.0 3328.4 4365.1 4803.6 3746.3 3517.0 2639.3 2903.4 3144.1 816.48 4088.5 True False 3143.4208526408793 4699.889133991292 4494.54160576423 3236.0474772720336 3075.1630176210733 3002.8396178200464 3038.4138529779566 3153.248810466227 979.7988143572976 3970.4543818012644 0.7917030521868917 1.1837156864295988 1.131996787663684 0.8150320255798897 0.7745116104887656 0.7562962142528777 0.7652559532996142 0.7941783250096686 0.24677246484640258 1.0 11.955088404589514 -5.921867217114839 3.976932381815341 0.7209575923045375 1.0492375087757142 0.3227983350869742 0.20172245392342897 0.248287466904945 7.649020139645987 0.057239642269151736 0.08718026244654625 1.197106483355923e-06 5.921867217114839 0.3282799164711767 SGS(ph)GNFGGGR ddPTM_A459_Selumetinib_30min_R2 3 SGSGNFGGGR 10 0 F8W6I7;P09651-2;P09651;F8VZ49;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.365)GS(0.635)GNFGGGR;S(0.004)GS(0.996)GNFGGGR;S(0.003)GS(0.997)GNFGGGR 92.792 0.026128 58200000.0 69526.0 52469.0 66598.0 76678.0 72415.0 56691.0 66167.0 77575.0 61707.0 85353.0 True False 65662.02325462985 56493.203585573974 62313.15718641977 66234.32412307219 63317.580301686125 64499.67066034037 69243.8966074232 77800.73040676735 74050.1242376369 82888.6371162735 0.7921715875545315 0.6815554646691456 0.7517695953790251 0.7990760425962948 0.7638873373302817 0.7781485243853427 0.8353846681094551 0.9386175610250534 0.8933688236876399 1.0 16.338886721323675 -7.748760137790503 0.6847211809914205 0.9928110763086736 0.7413512663972692 0.8418474021426879 0.03599183907003539 0.25130280392492915 0.23249237355144742 0.03332674682914942 0.016887288827603323 1.783363452749573e-08 7.748760137790503 -0.2514598099114044 SGS(ph)GSESTGAEER ddPTM_A459_Selumetinib_30min_R2 1 SGSGSESTGAEER 13 0 Q14669;Q14669-2;Q14669-3;G5E9G6;H7C1L9 Q14669;H7C1L9 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 S(0.027)GS(0.882)GS(0.002)ES(0.003)T(0.086)GAEER 104.81 0.0075167 1976000.0 2276.0 2645.2 2570.8 1892.0 2381.3 1790.1 2988.4 3826.4 3637.8 2597.5 True False 2149.509031549887 2848.0783343414264 2405.397526875404 1634.3063361179525 2082.1398049078934 2036.670026090126 3127.3665214022603 3837.5341905053783 4365.461648624557 2522.503425884501 0.8521332456847602 1.1290681729570948 0.9535755242956568 0.6478906309294278 0.8254259572225568 0.8074003013002765 1.2397868281608646 1.5213197140296328 1.7306068264679693 1.0 11.300640513360706 -7.4511808027626305 3.379531683468691 1.4633524383479055 0.8737766448467069 0.5952935436369172 0.20567674578362014 0.1638056164930959 3.6328107159026355 0.09824275126219664 0.06007413149848435 3.5384999779693827e-08 7.4511808027626305 -0.5895757935011986 SGS(ph)IVELIAGGGSS(ph)CSPVLSR ddPTM_A459_Selumetinib_30min_R1 1 SGSIVELIAGGGSSCSPVLSR 21 0 P42858 P42858 HTT Huntingtin 2 S(0.046)GS(0.954)IVELIAGGGS(0.007)S(0.7)CS(0.29)PVLS(0.003)R 100.9 0.0046991 2591000.0 470.49 521.8 741.21 654.04 650.8 438.51 749.36 519.99 176.55 522.86 True False 481.45150158582544 460.70741342176126 640.557753175093 539.8241918513447 591.9352549080724 434.0989875352238 692.8351718868025 506.19817603443573 299.59245529818367 589.9741740876893 0.8160552151800904 0.7808942046220572 1.085738632823418 0.9149963092640548 1.0033240112983175 0.7357932035016546 1.1743483059375828 0.8580005672573698 0.5078060505978258 1.0 9.204507992162588 -8.009568666309628 24.994927449051083 0.7302364294460937 0.9316623150309828 0.14469099401833052 0.1687476065854274 695.2539493870914 1816107.6832824496 0.09506149056306919 0.041503970590814475 9.782082780256229e-09 8.009568666309628 0.20142588558488916 SGS(ph)IVELIAGGGSSCS(ph)PVLSR ddPTM_A459_Selumetinib_30min_R1 2 SGSIVELIAGGGSSCSPVLSR 21 0 P42858 P42858 HTT Huntingtin 2 S(0.049)GS(0.949)IVELIAGGGS(0.135)S(0.114)CS(0.725)PVLS(0.027)R;S(0.04)GS(0.96)IVELIAGGGS(0.045)S(0.036)CS(0.692)PVLS(0.228)R 144.58 0.00012496 2118000.0 1042.1399999999999 1387.04 1291.26 1352.6999999999998 1238.83 881.3900000000001 896.27 908.3 634.5899999999999 912.27 True False 1066.4198343485566 1224.6447119825984 1115.9139843834691 1116.4763383238246 1126.7780452332013 872.5240168380903 828.6636323088833 884.2089334257918 1076.8528813802002 1029.3687407623001 1.0359939952701676 1.1897045864008717 1.0840760363065598 1.0846223458243125 1.0946301365230544 0.8476301856533371 0.8050211741374772 0.858981721915307 1.046129378848959 1.0 10.007544162107445 -6.751739838273563 24.69711111363687 0.896080643873413 1.1014158503563274 0.5955779266972181 0.07617947543687398 113.09104215380401 287953.48931406735 0.02553327535817064 0.025219178814661507 1.7711696500454819e-07 6.751739838273563 0.20533520648291437 SGS(ph)LKGPDDPR ddPTM_A459_Selumetinib_30min_R1 1 SGSLKGPDDPR 11 1 A8MVZ6;Q96G01-4;Q96G01-3;Q96G01 A8MVZ6 BICD1 Protein bicaudal D homolog 1 1 S(0.128)GS(0.872)LKGPDDPR 113.99 0.032193 11800000.0 2750.7 3514.0 4179.5 4217.3 3137.6 3632.6 2897.1 2820.0 1853.7 3285.7 True False 2814.785958069522 3102.5792463857197 3611.9468563501614 3480.8277235255914 2853.8046339882712 3596.0593421369044 2678.569414531409 2745.2044393490405 3145.5935111087088 3707.451600428263 0.7592239256054953 0.836849561576833 0.9742397866860704 0.9388734091966315 0.7697483181327617 0.9699544942735081 0.7224826385385574 0.7404559075112216 0.8484516725033843 1.0 11.856212143551595 -7.266715802219114 24.98852466785041 0.806218888885792 0.8757445246854936 0.03319065714422709 0.09977896515324057 1125.5505859576538 5330449.7141939895 0.040406516777386145 0.02816972723407832 5.4110830274417895e-08 7.266715802219114 0.06952563579970161 SGS(ph)MDPSGAHPSVR ddPTM_A459_Selumetinib_30min_R1 4 SGSMDPSGAHPSVR 14 0 Q07666-3;Q07666-2;Q07666 Q07666-3 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 S(0.01)GS(0.99)MDPSGAHPSVR;S(0.063)GS(0.935)MDPS(0.002)GAHPSVR;S(0.047)GS(0.953)MDPSGAHPSVR;S(0.02)GS(0.979)MDPS(0.002)GAHPSVR 135.57 0.00039837 42539200.0 7011.360000000001 8131.5 8584.8 9426.0 11279.71 7630.900000000001 9983.2 7578.990000000001 3518.8500000000004 5556.7 True False 7174.711046268342 7179.460199768207 7419.031312930939 7779.926047934033 10259.462222094551 7554.140074302845 9230.159186479576 7377.970565170919 5971.231443364558 6269.956571841532 1.1442999587094551 1.145057404705364 1.183266778313891 1.2408261458897172 1.636289199859844 1.2048153743565944 1.4721248992269511 1.1767179693565173 0.9523561088415583 1.0 12.614239735056891 -8.101364223238123 4.161914070618335 0.9823802482606154 1.2902232432955112 0.41057766749884805 0.14806309238684695 0.24382073020256023 7.096200144543528 0.1150584762337113 0.040499322131368136 7.918369739001702e-09 8.101364223238123 0.30784299503489576 SGS(ph)MDPSGAHPSVR ddPTM_A459_Selumetinib_30min_R2 5 SGSMDPSGAHPSVR 14 0 Q07666-3;Q07666-2;Q07666 Q07666-3 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 S(0.189)GS(0.811)MDPSGAHPSVR;S(0.354)GS(0.643)MDPS(0.003)GAHPSVR;S(0.001)GS(0.999)MDPSGAHPSVR;S(0.019)GS(0.98)MDPS(0.001)GAHPSVR;S(0.042)GS(0.958)MDPSGAHPSVR 222.56 4.7968e-09 96972600.0 177208.54 157938.4 315288.7 480953.0 571805.2 317997.8 198595.5 280403.10000000003 328099.6 414263.4 True False 167359.99876879135 170051.76742800145 295003.36830238125 415446.3717097977 499969.91877265373 361799.11045338423 207830.5842595177 281219.02659776795 393728.68786878337 402302.53925642365 0.4160053254402099 0.42269623190126604 0.733287363404756 1.0326715125330002 1.242770974542564 0.899320971530774 0.5166027155673719 0.6990237424738742 0.978688050531604 1.0 18.61792131844333 -5.382660075615629 3.3057795437740425 0.8940272821273963 0.4138892249329657 0.5216186119517503 0.18512490910085264 0.22558367133067253 4.543120512221985 0.05738988626608153 0.13698100093928928 4.1432384120752e-06 5.382660075615629 -0.48013805719443065 SGS(ph)NGGGQAPGASPSVSLPASLGR ddPTM_A459_Selumetinib_30min_R1 2 SGSNGGGQAPGASPSVSLPASLGR 24 0 P38432 P38432 COIL Coilin 1 S(0.182)GS(0.818)NGGGQAPGASPSVSLPASLGR;S(0.012)GS(0.988)NGGGQAPGASPSVSLPASLGR 200.57 7.7307e-31 11963000.0 1786.15 1877.17 2254.3 2435.5 2203.79 1965.8500000000001 2529.0 2196.7 1284.2 1998.99 True False 1827.7638197571098 1657.3900637273423 1948.1784419835303 2010.185644997173 2004.4575836107251 1946.0753338489883 2338.2354938904195 2138.4363801127784 2179.193605743004 2255.5798383114984 0.810329915488761 0.734795565901159 0.8637151338619495 0.8912057160884961 0.8886662088233771 0.8627827314265224 1.0366449700316511 0.9480650357797078 0.9661345471922305 1.0 11.139282637133698 -5.906720460761871 0.4443660416636875 0.9978355432143861 0.718294531983615 0.7383259061216525 0.043884147351741815 1.034310472109987 0.3192387516562256 0.03830756088385904 0.13904614214780797 1.2395942105851987e-06 5.906720460761871 -0.279541011230771 SGS(ph)NGGGQAPGASPSVSLPASLGR ddPTM_A459_Selumetinib_30min_R2 1 SGSNGGGQAPGASPSVSLPASLGR 24 0 P38432 P38432 COIL Coilin 1 S(0.174)GS(0.826)NGGGQAPGASPSVSLPASLGR 228.94 1.2818e-38 5141800.0 12504.0 13755.0 15796.0 14938.0 14193.0 12296.0 13659.0 14392.0 13337.0 14712.0 True False 11809.077737477934 14809.96427070405 14779.702557384413 12903.418630512677 12409.94845297012 13989.662388025354 14294.170564795031 14433.878337276145 16004.772666915627 14287.226333633414 0.8265479570151628 1.0365877830212615 1.0344696872752457 0.9031437123759193 0.8686044556987235 0.979172728235741 1.0004860447367079 1.010264553820184 1.1202155193159469 1.0 13.80243824398107 -7.562783242721299 1.7237817479427973 1.0548453567372766 0.9443838444410978 0.31948115940074606 0.0687162744058805 0.4917528084122133 2.8507073796096525 0.04691048648143667 0.0222424081525119 2.7366342453522634e-08 7.562783242721299 -0.11046151229617884 SGS(ph)PDLSEDQYFVK ddPTM_A459_Selumetinib_30min_R2 1 SGSPDLSEDQYFVK 14 0 Q9H706-2;Q9H706-3;Q9H706 Q9H706-2 GAREM GRB2-associated and regulator of MAPK protein 1 S(0.049)GS(0.944)PDLS(0.007)EDQYFVK 77.204 0.040645 51682000.0 11104.0 11332.0 13172.0 15727.0 18180.0 11479.0 12674.0 12972.0 11948.0 14352.0 True False 10486.884132833895 12201.127961877002 12324.52786058924 13584.955469411756 15896.065868737884 13060.128054012932 13263.36611305456 13009.74637236979 14337.93385501298 13937.620469025744 0.7524156764161724 0.8754096862511191 0.8842634141156764 0.9746969003498315 1.140515047318478 0.937041447142078 0.9516234239933845 0.9334266492104578 1.0287217884054793 1.0 13.766696654488394 -5.168899001386457 1.312782285642294 0.9927831017865072 0.7449478390319304 0.6146563103348741 0.06048035400927863 0.5370667525972744 1.2917888852239794 0.019780691428553186 0.14802605927183932 6.77799116823888e-06 5.168899001386457 -0.2478352627545768 SGS(ph)PISSEER ddPTM_A459_Selumetinib_30min_R1 1 SGSPISSEER 10 0 H8Y6P7;P0CAP2-3;P0CAP2;P0CAP1-11;P0CAP2-2 H8Y6P7 GCOM1;POLR2M DNA-directed RNA polymerase II subunit GRINL1A 1 S(0.041)GS(0.959)PISSEER 169.21 0.00024231 37685000.0 3260.3 2910.5 3253.5 3270.7 2493.0 2996.6 2673.9 2458.2 1660.5 2205.9 True False 3336.258646560535 2569.7373069452588 2811.692570196253 2699.533643642887 2267.508590174899 2966.4569246951064 2472.205570230761 2393.000550641068 2817.7472218784114 2489.0487522855715 1.3403749699546914 1.0324174263704538 1.1296253508953626 1.0845643907794242 0.9109940446496907 1.1918034638619088 0.9932330847118426 0.9614116832559799 1.1320578672036907 1.0 11.281378772912658 SGS(ph)PISSEER ddPTM_A459_Selumetinib_30min_R2 1 SGSPISSEER 10 0 H8Y6P7;P0CAP2-3;P0CAP2;P0CAP1-11;P0CAP2-2 H8Y6P7 GCOM1;POLR2M DNA-directed RNA polymerase II subunit GRINL1A 1 S(0.002)GS(0.992)PIS(0.004)S(0.001)EER 114.71 0.006874 67785000.0 44833.0 44092.0 39318.0 37793.0 48896.0 30433.0 39212.0 33449.0 32783.0 41909.0 True False 42341.36134071884 47473.714621874424 36788.32268620163 32645.528203438604 42753.24734421381 34624.869506731906 41035.43569710395 33546.331052219975 39340.51603355293 40698.97827734111 1.0403544052675178 1.1664596172013757 0.9039126838887571 0.8021215663198549 1.0504747085510104 0.8507552516621547 1.0082669746024107 0.8242548700761039 0.9666217113724327 1.0 15.312704956529538 -5.270654310260613 24.757797849711533 0.9198248748350474 1.103407012730125 0.4194043235230913 0.0833499575006388 431.89392533681325 1160374.2232907012 0.020325421471429062 0.04328598520344476 5.362233107398026e-06 5.270654310260613 0.1835821378950776 SGS(ph)PISSEERR ddPTM_A459_Selumetinib_30min_R2 1 SGSPISSEERR 11 1 H8Y6P7;P0CAP2-3;P0CAP2;P0CAP1-11;P0CAP2-2 H8Y6P7 GCOM1;POLR2M DNA-directed RNA polymerase II subunit GRINL1A 1 S(0.026)GS(0.974)PISSEERR 66.708 0.039473 12308000.0 15182.0 17400.0 18868.0 20988.0 21928.0 13409.0 11782.0 12060.0 12455.0 17484.0 True False 14338.245218361333 18734.524050181768 17654.053421925128 18129.398193680558 19173.208601192746 15255.9680352173 12329.886345590097 12095.092603359528 14946.34802177657 16979.191491112466 0.8444598334300252 1.1033813983420888 1.0397464114334247 1.0677421362006638 1.129217996700768 0.8985096871781459 0.7261762936146879 0.7123479707317363 0.8802744247039112 1.0 14.051480142354801 -6.963552741674434 5.600565159023147 0.8060477085292548 1.0414309046504242 0.4641139208228958 0.10464021222532924 0.1421767290727569 11.647173612751855 0.03680618898648113 0.03186620766877611 1.0875450557540887e-07 6.963552741674434 0.23538319612116942 SGS(ph)PKLDPSEVYLK ddPTM_A459_Selumetinib_30min_R2 2 SGSPKLDPSEVYLK 14 1 Q5TCQ9-3;Q5TCQ9-2;Q5TCQ9;Q5TCQ9-1 Q5TCQ9-3 MAGI3 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 1 S(0.075)GS(0.924)PKLDPS(0.001)EVYLK;S(0.425)GS(0.556)PKLDPS(0.018)EVYLK 82.774 0.016033000000000002 23920000.0 367750.0 439390.0 384550.0 359990.0 302850.0 171560.0 188413.0 182175.0 99111.0 297310.0 True False 347311.9272198908 473089.8001384705 359808.4716663822 310958.740982612 264803.2754866484 195190.83273337924 197174.57783327697 182705.09908930518 118935.96939271785 288725.88779585017 1.2029123189170525 1.6385430615524812 1.2461940091800585 1.0770033243519959 0.9171442072900758 0.6760420211137877 0.6829127077537761 0.63279777398586 0.41193385983044956 1.0 18.13934094300926 -6.146314427431558 1.1583080914626882 0.6456911069654372 1.4315316983481015 0.7475321039211835 0.17274725392683593 0.21844476085808093 0.6015406291396579 0.06684645362326824 0.11162109657268719 7.139792208665309e-07 6.146314427431558 0.7858405913826643 SGS(ph)PLEKDSDGLR ddPTM_A459_Selumetinib_30min_R1 1 SGSPLEKDSDGLR 13 1 Q9NRA8;Q9NRA8-3;B1AKL4;B1AKL5 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.017)GS(0.983)PLEKDSDGLR 139.64 0.0043877 3814200.0 1037.5 832.42 2424.4 2392.8 1476.6 1237.4 1383.2 1090.0 801.8 1075.0 True False 1061.671731376424 734.9598794184411 2095.1797962759492 1974.9423984189018 1343.041790714903 1224.9528794693076 1278.8641103792916 1061.0896591810124 1360.5960388449937 1212.9867213867312 0.8752542073689659 0.6059092539596871 1.727289968912984 1.628164895458274 1.107218873080068 1.0098650363368333 1.0543100660799047 0.8747743404543914 1.1216907941824046 1.0 10.244348041967692 -6.519012349433288 23.361714456579694 1.012671484423884 1.2236523041986767 0.08230175926658467 0.30871865676004856 200.7803626048226 1213187.178919989 0.11148118251703566 0.11416558290184033 3.026827357162025e-07 6.519012349433288 0.21098081977479266 SGS(ph)PMVPSYETSVSPQANR ddPTM_A459_Selumetinib_30min_R1 1 SGSPMVPSYETSVSPQANR 19 0 Q9Y2I7;E9PDH4;Q9Y2I7-2;Q9Y2I7-3;Q9Y2I7-4 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 S(0.037)GS(0.849)PMVPSYET(0.006)S(0.02)VS(0.087)PQANR 137.79 0.00015603 6331300.0 1001.7 1496.5 984.55 1242.0 954.34 956.94 1156.9 1186.4 803.65 965.97 True False 1025.0376610310977 1321.289084296025 850.8535177460344 1025.1080152274644 868.0201155024123 947.3140524320016 1069.6341015744658 1154.9328180296825 1363.7353537263393 1089.9616588445963 0.9404346040187133 1.2122344612531097 0.78062701641081 0.9404991514234736 0.7963767426668465 0.8691260327782475 0.9813502088764494 1.0596086648166674 1.2511773626715956 1.0 10.090061671437095 -7.78643851967651 2.846603169313823 1.1310263242994658 0.9257759472010649 0.29499700422086195 0.12538466573290993 0.33179826761255693 5.408924613496637 0.08030267426810087 0.035738400048970276 1.6351646146603658e-08 7.78643851967651 -0.20525037709840088 SGS(ph)PMVPSYETSVSPQANR ddPTM_A459_Selumetinib_30min_R2 2 SGSPMVPSYETSVSPQANR 19 0 Q9Y2I7;E9PDH4;Q9Y2I7-2;Q9Y2I7-3;Q9Y2I7-4 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 S(0.199)GS(0.8)PMVPSYETSVSPQANR;S(0.174)GS(0.811)PMVPS(0.013)Y(0.002)ETSVSPQANR 149.86 2.9394e-05 16998400.0 47948.0 40257.0 44044.0 44644.0 46123.0 36788.1 37417.7 35390.0 32957.1 37441.0 True False 45283.24211105186 43344.58245334299 41210.25699148136 38563.4101848044 40328.61639514839 41855.32684587795 39157.697191765954 35492.97904087011 39549.44089831334 36359.98104659931 1.2454143486218108 1.1920958483942043 1.1333959976124819 1.0606003929259797 1.109148443819672 1.1511372019758688 1.0769449285900636 0.9761550479188084 1.0877189635392381 1.0 15.150063827046697 -1.5228787453021213 0.23681670407483835 1.012504854505588 2.3511395116139227 0.705347478927804 0.04236315477085405 29.96491367637355 0.39786278139191966 0.06330086560112738 15.695809515315966 0.029999999998495234 1.5228787453021213 1.3386346571083347 SGS(ph)PNLPHSVSSYK ddPTM_A459_Selumetinib_30min_R1 2 SGSPNLPHSVSSYK 14 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 S(0.014)GS(0.985)PNLPHSVSSYK;S(0.143)GS(0.854)PNLPHS(0.002)VSSYK 148.41 0.00045994 37459000.0 6462.200000000001 7259.4 7214.1 8244.0 8820.6 6537.299999999999 7632.200000000001 6391.5 2058.0 4353.4 True False 6612.7566867476935 6409.466073196501 6234.464844214787 6804.340159046062 8022.778287403416 6471.540697393484 7056.497009280531 6221.97665748206 3492.275689627085 4912.201295706972 1.3461900864133816 1.304805256820006 1.26917943075 1.3851916380122142 1.63323483799716 1.3174420810175878 1.4365243980224447 1.2666371516411121 0.7109390432918875 1.0 12.262153966373404 -8.127298464977645 4.675328357946861 0.8626501796201471 1.3822215753907887 0.7629306935580604 0.11599799610404597 0.10520058241602556 3.4323871722392663 0.08550024847292462 0.030408632995611286 7.459359444462635e-09 8.127298464977645 0.5195713957706416 SGS(ph)PNLPHSVSSYK ddPTM_A459_Selumetinib_30min_R2 2 SGSPNLPHSVSSYK 14 0 Q5T481 Q5T481 RBM20 RNA-binding protein 20 1 S(0.427)GS(0.571)PNLPHS(0.002)VS(0.001)SYK;S(0.009)GS(0.989)PNLPHS(0.002)VSSYK 211.45 3.5784e-06 28140000.0 36864.0 35200.0 46476.0 59375.0 55084.0 43651.0 39945.0 43092.0 37587.0 46956.0 True False 34815.24645828429 37899.72681416083 43485.78475924274 51288.022572411995 48163.85546279197 49663.52902567455 41802.52164951592 43217.39058573539 45105.450268528 45600.25827366032 0.763487922575963 0.8311296525277033 0.9536302294226491 1.1247309667550074 1.0562189181856552 1.0891063100482758 0.9167167738096331 0.9477444256209109 0.989149008714757 1.0 15.476754375191083 -5.26494714513135 2.7909514765299175 1.0168026899908813 0.7793148916851715 0.6802119753881893 0.05992253781026733 0.1714616306076061 2.621442216086647 0.018108015876243957 0.05555998476802203 5.433164506199727e-06 5.26494714513135 -0.23748779830570976 SGS(ph)PRPTEPTDFLMLFEGS(ph)PSGK ddPTM_A459_Selumetinib_30min_R1 2 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 2 S(0.393)GS(0.47)PRPT(0.126)EPT(0.011)DFLMLFEGS(0.811)PS(0.189)GK;S(0.318)GS(0.403)PRPT(0.229)EPT(0.051)DFLMLFEGS(0.911)PS(0.088)GK 107.18 3.6557e-05 16460800.0 3901.3500000000004 4430.24 4972.13 5027.78 3959.52 4064.29 3978.8100000000004 3787.73 2098.89 3502.04 True False 3992.2438642943766 3911.545441237299 4296.9420559550945 4149.772606119434 3601.3821151100333 4023.406932680062 3678.6851583416924 3687.2670961189856 3561.663033139645 3951.5609467583135 1.0102954042931913 0.9898734940292794 1.0874037156076553 1.0501603447426833 0.9113821509103759 1.0181816722277022 0.9309448109004933 0.9331165951378928 0.9013306592326449 1.0 11.948206944357342 -6.252484598054551 24.986142945449608 0.9483555368205074 1.0350340099356128 0.5024071945779328 0.0415685387724018 554.0948995914198 1546067.0243130636 0.012572711091828689 0.015990594312601827 5.59133356486449e-07 6.252484598054551 0.08667847311510535 SGS(ph)PRPTEPTDFLMLFEGSPSGK ddPTM_A459_Selumetinib_30min_R1 2 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.115)GS(0.759)PRPT(0.093)EPT(0.033)DFLMLFEGSPSGK;S(0.015)GS(0.385)PRPT(0.267)EPT(0.333)DFLMLFEGSPSGK 85.712 0.00050359 37609000.0 3457.03 3685.2400000000002 4480.9 4619.9 3823.0 3601.4100000000003 3834.0499999999997 3416.8 1840.3999999999999 3165.71 True False 3537.5720727905955 3253.770387578406 3872.418391821853 3813.1211912635767 3477.210325005471 3565.183085218648 3544.8445216886334 3326.175364669433 3123.0243825022762 3572.059715126685 0.9903451663503708 0.9108947349898961 1.0840855698529428 1.0674852873024667 0.9734468632426403 0.998074883832732 0.9923810922525167 0.9311645464895225 0.8742923219556301 1.0 11.802540483261488 -7.732060762984762 4.0864547092198755 0.9257230356455474 1.004138175527868 0.2477177463847675 0.05332767144312053 0.28327472899035305 10.311169045982822 0.02965812240368766 0.015165061118034152 1.853272310345038e-08 7.732060762984762 0.07841513988232063 SGS(ph)PSDNSGAEEMEVSLAKPK ddPTM_A459_Selumetinib_30min_R1 1 SGSPSDNSGAEEMEVSLAKPK 21 1 P31749-2;P31749 P31749-2 AKT1 RAC-alpha serine/threonine-protein kinase 1 S(0.033)GS(0.579)PS(0.314)DNS(0.074)GAEEMEVSLAKPK 101.58 0.00013126 9215500.0 2090.1 2360.9 2976.2 3013.2 2236.3 2360.5 2324.6 2113.4 1445.3 2073.1 True False 2138.795263373364 2084.4847304473683 2572.0483870963867 2487.001184769238 2034.0270598508337 2336.7555131625177 2149.253550453802 2057.3457667093126 2452.5685394645407 2339.20257870403 0.9143266525288731 0.8911091110382662 1.0995406770290748 1.0631833289731971 0.8695386532010962 0.9989538890031199 0.9187975295600673 0.8795073096444377 1.0484635070910864 1.0 11.191801091472678 -6.256081167599885 24.99646531296376 0.9471520705290672 0.9925092141223156 0.05614805863040717 0.07745259059710571 1392.1011413953079 6494261.804125933 0.02403276164183983 0.030129734597514658 5.545220657017275e-07 6.256081167599885 0.045357143593248384 SGS(ph)PSDNSGAEEMEVSLAKPK ddPTM_A459_Selumetinib_30min_R2 1 SGSPSDNSGAEEMEVSLAKPK 21 1 P31749-2;P31749 P31749-2 AKT1 RAC-alpha serine/threonine-protein kinase 1 S(0.259)GS(0.474)PS(0.253)DNS(0.014)GAEEMEVSLAKPK 70.112 0.011999 11050000.0 42152.0 32087.0 38886.0 47641.0 34625.0 26716.0 31261.0 36057.0 27287.0 35895.0 True False 39809.360587825526 34547.9697240335 36384.11709587558 41152.21361469104 30275.097948572573 30395.88649629842 32714.698442496338 36161.91990044231 32745.16246248235 34858.61808358969 1.1420234873443387 0.9910883340581298 1.0437624638081695 1.180546329060135 0.8685111347780339 0.871976233349532 0.9384967116036468 1.0373882238741465 0.93937064240357 1.0 15.08922775671615 -6.268891932912061 24.99932022874013 0.9407545015339893 1.0790794753619635 0.526608401333223 0.06786154274361257 516.7126771269153 1733291.353597951 0.02199382570075344 0.025415430992593614 5.384037388251524e-07 6.268891932912061 0.13832497382797415 SGS(ph)PVATFK ddPTM_A459_Selumetinib_30min_R1 1 SGSPVATFK 9 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 1 S(0.002)GS(0.998)PVATFK 100.69 0.017694 10364000.0 3141.4 3506.8 4132.6 3898.2 3137.7 2837.7 3286.3 2932.4 1945.8 2716.7 True False 3214.5885078996625 3096.22222573291 3571.415618746901 3217.4525482767303 2853.895589005929 2809.1553144254494 3038.4117451846905 2854.6232262223866 3301.8804843908547 3065.414907898911 1.0486634287633831 1.0100499667286849 1.1650676094593706 1.0495977363410254 0.930998143726664 0.9164029662630216 0.9911910251872791 0.9312355136221984 1.0771398272653476 1.0 11.581866642446558 -6.120092782354007 5.682500744896516 0.9694492855902075 1.0740078394087333 0.4013033683698979 0.05645467910760196 0.2245219577253537 9.553252235804335 0.016798665286643977 0.02192011747710146 7.584155303836009e-07 6.120092782354007 0.10455855381852586 SGS(ph)PVATFK ddPTM_A459_Selumetinib_30min_R2 1 SGSPVATFK 9 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 1 S(0.309)GS(0.69)PVAT(0.001)FK 84.198 0.036879 13956000.0 164760.0 146400.0 153040.0 196800.0 153010.0 126410.0 129350.0 150670.0 110130.0 151670.0 True False 155603.29878653758 157628.4092498054 143193.57301735313 169995.5005010637 133787.51587324444 143821.83006427163 135365.03130216233 151108.42475523875 132159.07728930193 147290.89301401447 1.056435300258056 1.070184354404093 0.9721821226498268 1.1541480740760324 0.9083217104299504 0.9764475394319677 0.9190319138691255 1.0259183148605193 0.8972657751265534 1.0 17.16830870583101 -6.280105918339853 24.99612011068135 0.9551176770242517 1.0572297281338028 0.4757030440255322 0.055781473790357555 722.0000485499374 966818.183110251 0.016184698400701632 0.018382861790768555 5.246794826691536e-07 6.280105918339853 0.10211205110955113 SGS(ph)SPGLR ddPTM_A459_Selumetinib_30min_R1 1 SGSSPGLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.009)GS(0.658)S(0.333)PGLR 104.42 0.014616999999999996 3157900.0 1763.6 2054.1 2017.7 1602.6 2133.1 2225.4 1872.2 1723.8 1184.1 1508.2 True False 1804.68844863177 1813.6050170748179 1743.7074224327596 1322.7359945278042 1940.1614816293932 2203.014496501531 1730.978446683133 1678.0792243084666 2009.331216757739 1701.7921611120623 1.0604634865943139 1.0657030032913595 1.0246300707445422 0.7772605990048996 1.140069584267896 1.2945261747250836 1.0171503231934025 0.986065903142896 1.1807148150481024 1.0 10.73283913693724 SGS(ph)SPGLR ddPTM_A459_Selumetinib_30min_R2 3 SGSSPGLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.313)GS(0.592)S(0.094)PGLR;S(0.028)GS(0.865)S(0.108)PGLR;S(0.081)GS(0.54)S(0.379)PGLR 131.22 0.0036226 270259000.0 243652.0 162597.0 168904.0 239260.0 242146.0 175833.0 245052.0 341702.0 227011.0 313600.0 True False 230110.79725623588 175067.66706824192 158036.9005287702 206672.3752534791 211725.45466729402 200052.399696947 256447.40356132586 342696.2962481884 272419.5432173044 304545.55316934735 0.7555874477939895 0.5748488698861178 0.5189269680154919 0.6786254900217036 0.6952176857087805 0.6568882638903767 0.8420658285518431 1.1252710561090569 0.8945116432740071 1.0 18.216298513459066 -7.434318616059777 2.950220878040346 1.0075460443149828 0.6399311980718062 0.7970929887632889 0.08154345280289628 0.11318647847927236 1.9076709403439243 0.03997540176108482 0.02410750255849435 3.6785899832978117e-08 7.434318616059777 -0.36761484624317664 SGS(ph)SQELDVKPSAS(ph)PQER ddPTM_A459_Selumetinib_30min_R2 1 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.068)GS(0.536)S(0.396)QELDVKPS(0.015)AS(0.985)PQER 160.12 0.00047359 4328600.0 62647.0 41878.0 51706.0 58882.0 52798.0 50322.0 71382.0 70578.0 49856.0 45950.0 True False 59165.33053581099 45089.907941006495 48379.2922532362 50862.17002288446 46165.04321989125 57253.39872236594 74701.40444074964 70783.37029518317 59828.59309303035 44623.30410756221 1.3258841253259948 1.0104565056930692 1.0841710003504081 1.1398118324067572 1.0345500886400694 1.2830380866544424 1.6740446709344001 1.58624224966765 1.3407477166822197 1.0 15.445509720632892 -6.996542842600595 6.5202111023909834 1.4538166927675507 1.1155237629272008 0.32212745610568727 0.18663532825397117 0.13608971152516178 28.08106857003975 0.06542387619047182 0.055141785564346756 1.0079921673088012e-07 6.996542842600595 -0.33829292984034987 SGS(ph)SQELDVKPSASPQER ddPTM_A459_Selumetinib_30min_R1 1 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.055)GS(0.472)S(0.472)QELDVKPSASPQER 67.097 0.016583 56284000.0 1668.1 3371.1 2095.6 2481.4 1867.9 2122.1 1857.5 1735.1 1003.5 1750.8 True False 1706.9634844424224 2976.4100448181266 1811.0290303068293 2048.070071646882 1698.9487748045292 2100.753600712635 1717.3872795181708 1689.0795116008933 1702.8662072598531 1975.532234236176 0.8640524588060728 1.5066370435453473 0.9167296786767185 1.036718123933195 0.8599954712768402 1.0633861418742554 0.8693289078030079 0.854999722266725 0.8619784469972229 1.0 10.948025671242554 -5.395509659204046 19.61704562400644 0.9311563763378231 1.1920580377790195 0.28173275119731767 0.16112715488076304 3.498520326812759 529.6166199416842 0.03884740417959622 0.08086750575283223 4.022447095185979e-06 5.395509659204046 0.2609016614411964 SGS(ph)TGSSLSVSVR ddPTM_A459_Selumetinib_30min_R2 1 SGSTGSSLSVSVR 13 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 1 S(0.003)GS(0.744)T(0.213)GS(0.018)S(0.018)LS(0.004)VSVR 86.699 0.038744 0.0 10952.0 8334.1 7937.9 7165.6 9407.9 5528.9 9298.7 9105.1 6693.6 9681.1 True False 10343.33168432969 8973.298671644823 7427.184156132043 6189.632918650529 8225.995494306886 6290.455788642921 9731.107975024499 9131.59433356955 8032.5070348104155 9401.581488481408 1.1001693382120967 0.9544456624280386 0.7899930628939026 0.658360822190811 0.8749586975749961 0.6690848551756783 1.0350501122547116 0.9712827937254345 0.8543782814254868 1.0 13.198687745035157 -10.09095329553754 9.677277314487574 0.9999959462498622 0.8728349049186236 0.06411907154602026 0.13750205954400063 0.0 0.0 0.140276057507131 0.03402194128512461 8.110482741057595e-11 10.09095329553754 -0.12716104133123862 SGS(ph)VSNYR ddPTM_A459_Selumetinib_30min_R1 3 SGSVSNYR 8 0 Q13131;Q13131-2 Q13131 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 SGS(0.998)VS(0.002)NYR;S(0.032)GS(0.919)VS(0.049)NYR;S(0.135)GS(0.863)VS(0.002)NYR 150.15 0.002448 57227200.0 10784.5 13831.2 13527.9 14833.6 12239.3 13145.0 12499.6 13476.5 7392.6 10151.8 True False 11035.757867015947 12211.836674049568 11690.885483435653 12243.190221157902 11132.257476023917 13012.773234705055 11556.745108514304 13119.059442158632 12544.70226585868 11454.88241690587 0.9634108378736956 1.06608136422479 1.02060283623527 1.0688184981356592 0.9718351590928771 1.1360023404081343 1.0088925130700686 1.1452810220728813 1.095140203913781 1.0 13.483675029163889 -6.760128956928724 24.999999821309668 1.0818826054122994 1.023763828040077 0.22272432551266563 0.054153629650517246 53.799298467704126 1026375.2882652158 0.017367453450868105 0.01644743800312721 1.737284892677116e-07 6.760128956928724 -0.058118777372222485 SGS(ph)VYEPLK ddPTM_A459_Selumetinib_30min_R2 3 SGSVYEPLK 9 0 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L3F2;H3BV13;H3BQ89 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 S(0.179)GS(0.821)VYEPLK;S(0.002)GS(0.998)VYEPLK;S(0.002)GS(0.998)VYEPLK 104.79 0.014119 8879900.0 112686.0 85884.0 88295.0 100105.0 90542.0 60678.0 74970.0 79892.0 70066.0 78669.0 True False 106423.36323779903 92471.02663941451 82614.19582832712 86470.52630924291 79167.30450424999 69035.84371995779 78456.25355023684 80124.47249316737 84081.15780761123 76397.62156339089 1.3930193252088914 1.2103914329674088 1.0813713063014407 1.131848407577637 1.036253523135677 0.9036386514032421 1.0269462837287127 1.0487822899916346 1.1005729771030233 1.0 16.221240104039353 -4.053181493538128 0.748780685971481 1.0209344615243945 2.2284328160334588 0.8196514254357924 0.053640042598639956 3.0953336595514314 0.6009000885835128 0.02229154245147748 4.047890428711108 8.847457934771945e-05 4.053181493538128 1.2074983545090643 SGS(ph)YSYLEER ddPTM_A459_Selumetinib_30min_R1 2 SGSYSYLEER 10 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;H0YIM2;H0YIS3;A0A0U1RQZ1 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 S(0.148)GS(0.814)YS(0.038)YLEER;S(0.225)GS(0.774)YSYLEER 174.57 7.9616e-05 48825000.0 5043.8 5601.9 6384.9 6829.0 5785.6 5543.6 5745.2 5301.9 2969.9 3549.4 True False 5161.310726473649 4946.026943747343 5517.86564974522 5636.443346206403 5262.293501530646 5487.836417186078 5311.834938512941 5161.276389001658 5039.703387086239 4005.0000640837793 1.2887167650156826 1.2349630123860789 1.377744210100915 1.4073516244739055 1.3139309406564257 1.3702462745007535 1.3263008373329765 1.2887081913648855 1.2583528855046766 1.0 11.967586550380554 -8.964500399794924 1.058775329244074 0.9996722952220001 1.3330087222529945 0.8182317798930017 0.04627750970602018 0.6773369952040195 1.1616279725089549 0.04861678027970321 0.015245169446883332 1.0851745506620492e-09 8.964500399794924 0.3333364270309944 SGS(ph)YSYLEER ddPTM_A459_Selumetinib_30min_R2 2 SGSYSYLEER 10 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;H0YIM2;H0YIS3;A0A0U1RQZ1 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 SGS(0.999)YSYLEER;S(0.006)GS(0.994)YSYLEER 185.99 9.9346e-05 49535000.0 77409.0 70392.0 85229.0 80514.0 73383.0 60183.0 57215.0 63157.0 50819.0 70069.0 True False 73106.91767277902 75790.84005404591 79745.4589303187 69547.85430560294 64163.971487656396 68472.66196312061 59875.610869371696 63340.77641379577 60984.2200014985 68045.92590887425 1.0743761172517858 1.1138189251116002 1.171935833999999 1.0220722751093143 0.9429509648172545 1.0062712946961414 0.8799294016449408 0.9308533254234864 0.8962214737612263 1.0 16.054221165863353 -6.022310132245163 3.2443189038745253 0.9396978055179293 1.1190908634010237 0.7661641544504535 0.043695217940951714 0.11420471760390637 2.473424696380352 0.01336471415294579 0.01927265870368192 9.4992620350068e-07 6.022310132245163 0.17939305788309445 SGSDAGEARPPT(ph)PASPR ddPTM_A459_Selumetinib_30min_R1 1 SGSDAGEARPPTPASPR 17 1 Q96FS4;F6RY50;E9PIB3 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 SGSDAGEARPPT(0.5)PAS(0.5)PR 156.17 0.00049336 5476000.0 892.6 1076.2 1289.8 1219.0 1099.9 1065.5 1014.5 961.49 922.18 1074.4 True False 913.3958433027437 950.1980036881937 1114.6522443642632 1006.1245334639927 1000.4142392031174 1054.782037396595 937.9754482213643 935.988161840323 1564.8721066376597 1212.3097055422354 0.7534344063460293 0.7837914679262542 0.9194451213815099 0.8299236811058761 0.825213420819441 0.8700598803874275 0.7737094274947107 0.7720701711463072 1.2908187565303142 1.0 10.243542592030948 -8.250651937247289 24.97766549761527 1.1454093838983725 0.8195028492030902 0.7276546648861406 0.08059821364233885 296.7710484258047 687159.2428988061 0.05272035304556924 0.019489807880726465 5.6149780485819616e-09 8.250651937247289 -0.3259065346952823 SGSDAGEARPPT(ph)PASPR ddPTM_A459_Selumetinib_30min_R2 1 SGSDAGEARPPTPASPR 17 1 Q96FS4;F6RY50;E9PIB3 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 SGSDAGEARPPT(0.629)PAS(0.371)PR 130.4 0.008956299999999999 3263500.0 10293.0 7239.8 9513.7 11765.0 9902.3 7065.9 9760.6 9842.2 9074.9 9797.9 True False 9720.956266143672 7795.069380373909 8901.598899733359 10162.586704242984 8658.284546314808 8039.163587146086 10214.487240261977 9870.83917253608 10890.13357389163 9515.009168998562 1.0216444454742217 0.8192392925664753 0.935532351217927 1.0680585298177467 0.9099607149644058 0.8448928891565318 1.0735131263501487 1.0373967063213 1.1445216058617627 1.0 13.2159893313939 -7.28689308616751 24.270049156253886 1.0669742892795806 0.9332170702973044 0.4105231383179 0.07665289991510857 550.9161095805642 525294.3523803425 0.03243152058095479 0.021876512283229576 5.1654351537237876e-08 7.28689308616751 -0.13375721898227622 SGSDAGEARPPTPAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SGSDAGEARPPTPASPR 17 1 Q96FS4;F6RY50;E9PIB3 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 SGSDAGEARPPT(0.195)PAS(0.805)PR 183.6 3.0799e-07 6737700.0 1126.4 1408.7 1434.4 1337.9 1618.7 1247.0 1184.3 1241.1 720.99 948.87 True False 1152.6429284071367 1243.7687491131367 1239.616358595207 1104.2608804934175 1472.2888708046958 1234.45631218541 1094.9672975145997 1208.1819963390403 1223.4673709738731 1070.6667072764903 1.0765655834570345 1.1616768698047732 1.1577985475503227 1.0313768729228374 1.375114086203196 1.1529790772382935 1.022696689897012 1.1284389326089672 1.1427154339057293 1.0 10.064293731516821 -9.450046388513979 0.535437832066649 0.9896408336835247 1.1499547998942696 0.1699245386608399 0.09259445321229806 7.047542111170019 2.5880544506811147 0.2671223441053199 0.044396266018003325 3.54775492397333e-10 9.450046388513979 0.1603139662107449 SGSDAGEARPPTPAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SGSDAGEARPPTPASPR 17 1 Q96FS4;F6RY50;E9PIB3 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 SGSDAGEARPPT(0.043)PAS(0.957)PR 120.99 0.006859399999999999 3315700.0 9393.6 7622.9 9025.4 9477.4 10585.0 7383.2 9455.0 8793.2 5852.2 8316.7 True False 8871.541317560204 8207.551918513256 8444.715590112517 8186.561770573088 9255.21766889937 8400.168781983475 9894.676234727067 8818.786756207375 7022.8035241301395 8076.575261618338 1.0984286074469856 1.01621685586431 1.0455812416239916 1.0136179637274514 1.1459334394965894 1.0400656850067287 1.2251079095057462 1.0918968090492749 0.8695274044561989 1.0 12.979527956293227 -8.24703792615085 24.397997996705538 0.9347637064183186 1.0839022960919793 0.44125479903146114 0.06744236562402983 470.8605484549359 797705.5749402934 0.04676704018052397 0.01748187751156053 5.661898425453382e-09 8.24703792615085 0.14913858967366067 SGSDSDDDDSHSK ddPTM_A459_Selumetinib_30min_R1 1 SGSDSDDDDSHSK 13 0 O75400-3;O75400;O75400-2 O75400-3;O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 85.845 0.038303 980200.0 839.18 815.98 1090.8 854.12 753.28 710.48 851.15 742.25 466.18 741.21 False True 858.7312612399686 720.4446822611892 942.6753513355073 704.9639758181013 685.1459570023857 703.3332162642258 786.9470702352033 722.5631188322081 791.0734115599389 836.3515234967984 1.02675876962548 0.8614137261913496 1.1271281570626754 0.8429039178055612 0.8192081173449413 0.8409540683606086 0.9409286025389966 0.8639466761669313 0.9458623429684793 1.0 9.707965632814647 -5.811200149194991 24.99999860817153 0.8844353268594161 0.9907343135533974 0.27721016050103486 0.08076808773844871 135.84415419993363 68247.92405192532 0.02192260029327083 0.03251653891512206 1.544542456798233e-06 5.811200149194991 0.1062989866939813 SGSGSVGNGSS(ph)RYSPSQNSPIHHIPSR ddPTM_A459_Selumetinib_30min_R2 1 SGSGSVGNGSSRYSPSQNSPIHHIPSR 27 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.01)GS(0.009)GS(0.023)VGNGS(0.066)S(0.182)RY(0.163)S(0.182)PS(0.182)QNS(0.182)PIHHIPSR 45.57899999999999 0.02352 3771900.0 15626.0 13644.0 13150.0 16635.0 16608.0 7356.5 10509.0 11197.0 6459.5 15422.0 True False 14757.56947583415 14690.450927625303 12303.943316637451 14369.2843030244 14521.554562596199 8369.791099341937 10997.689323188446 11229.581416236866 7751.580493509902 14976.726788831867 0.9853668083762374 0.9808852851999651 0.8215375422226765 0.9594409049205307 0.969608030335768 0.558853160463826 0.734318618363888 0.7498021146123034 0.5175750751686443 1.0 13.870434732217053 -6.744562431240009 24.999917070867212 0.6978604696687839 0.9395766925666007 0.4438384089310906 0.1289085704633697 211.71859907136647 313619.37913724175 0.040287767552168646 0.040186727958901554 1.8006842616339875e-07 6.744562431240009 0.2417162228978168 SGSGSVGNGSSRYS(ph)PSQNS(ph)PIHHIPSR ddPTM_A459_Selumetinib_30min_R2 2 SGSGSVGNGSSRYSPSQNSPIHHIPSR 27 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 2 SGSGS(0.001)VGNGS(0.022)S(0.022)RY(0.169)S(0.759)PS(0.118)QNS(0.909)PIHHIPSR;S(0.002)GS(0.006)GS(0.016)VGNGS(0.093)S(0.093)RY(0.303)S(0.541)PS(0.136)QNS(0.807)PIHHIPS(0.002)R 71.857 0.00088401 9182500.0 17252.9 23433.0 28110.0 29097.0 31276.0 15752.6 12503.5 10760.900000000001 8297.8 25847.0 True False 16294.052886830874 25230.235751029286 26301.433203853907 25133.93840487531 27346.829269012418 17922.377662134688 13084.937525215226 10792.212437437112 9957.591859903461 25100.72995142895 0.6491465753530118 1.0051594435640292 1.0478353918291767 1.0013230074786916 1.0894834262561197 0.7140181857983932 0.5212970917792101 0.4299561191375921 0.3967052702918143 1.0 14.615441699183425 -6.968986114071817 4.121734720356756 0.5454789254461853 0.9674002127917412 0.45085828090603364 0.19226318293212752 0.17211937291635265 6.560369211182563 0.0702749367629747 0.059405683432047225 1.0740237521242471e-07 6.968986114071817 0.4219212873455559 SGSIGAADS(ph)PENWEK ddPTM_A459_Selumetinib_30min_R1 1 SGSIGAADSPENWEK 15 0 D6RAI0;D6RGK7;D6RAZ3;D6R9T3;E7EMP6;Q96FZ2 D6RAI0 HMCES Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein 1 SGSIGAADS(1)PENWEK 147.75 0.00031792 7325600.0 2904.2 2855.1 2998.3 3022.1 2776.3 2674.3 2834.0 2722.3 1519.4 2374.6 True False 2971.862209410519 2520.823564700019 2591.147328482998 2494.3469668429307 2525.184155195577 2647.3989700701222 2620.229098333509 2650.095760723367 2578.310827414669 2679.403040562727 1.1091508684659737 0.9408153706396469 0.9670614272120878 0.9309338420094758 0.9424428191531944 0.9880555220666305 0.9779152515193121 0.98906201142729 0.9622706208742576 1.0 11.387695894915339 -10.497256303035318 18.074316430789413 0.9999999999997595 0.9752767483534718 0.013416672666992091 0.04769818647248236 0.0 0.0 0.04478874096118405 0.010862865283611184 3.18231889155494e-11 10.497256303035318 -0.024723251646287747 SGSIVELIAGGGSSCS(ph)PVLSR ddPTM_A459_Selumetinib_30min_R1 2 SGSIVELIAGGGSSCSPVLSR 21 0 P42858 P42858 HTT Huntingtin 1 SGSIVELIAGGGSS(0.002)CS(0.998)PVLSR;SGSIVELIAGGGSS(0.004)CS(0.996)PVLSR 243.99 1.6979999999999999e-31 142044000.0 6807.6 7750.5 8245.2 8538.9 7284.5 7055.9 6711.4 6392.4 3295.0 5734.5 True False 6966.203834716289 6843.067856890307 7125.547127641666 7047.741410004659 6625.618261182931 6984.924052244608 6205.153694620862 6222.852786558446 5591.374342721694 6470.578933760195 1.076596685710791 1.057566552690773 1.101222502744566 1.0891979654607293 1.0239606577726483 1.0794898143967957 0.9589796768022597 0.961714994942842 0.8641227315146011 1.0 12.659679083046674 -7.349232330805382 2.576204790246696 0.9350337961819442 1.0721972801397475 0.7255850568068792 0.03754060960342023 0.14655856673560094 1.8989811892659085 0.017676428404307012 0.011041119987171805 4.474738588710861e-08 7.349232330805382 0.1371634839578033 SGSIVELIAGGGSSCS(ph)PVLSR ddPTM_A459_Selumetinib_30min_R2 2 SGSIVELIAGGGSSCSPVLSR 21 0 P42858 P42858 HTT Huntingtin 1 SGSIVELIAGGGS(0.272)S(0.164)CS(0.56)PVLS(0.003)R;SGSIVELIAGGGS(0.001)S(0.097)CS(0.901)PVLSR 135.98 3.4851e-05 46746000.0 137322.0 116253.0 142179.0 145605.0 153686.0 87837.0 119287.0 114634.0 95329.0 121845.0 True False 129690.1929835208 125169.23128768853 133031.35793279036 125773.34781736515 134378.59070972764 99935.7494451026 124834.08186270631 114967.56596131976 114397.46371480863 118327.01825867067 1.0960319535814675 1.0578246044708093 1.1242686572391696 1.0629300870441636 1.1356543305770384 0.8445725322566353 1.0549922046527935 0.9716087471247952 0.9667907245387375 1.0 16.852420004220193 -6.731932497160871 24.999862128146432 0.9712806959420273 1.0930640331196069 0.5851895720424596 0.053715967508851784 149.1463344728798 126364.63714451532 0.01674244559484303 0.016740112210399703 1.853819742136954e-07 6.731932497160871 0.12178333717757961 SGSLDDS(ph)FSDFQELPASSK ddPTM_A459_Selumetinib_30min_R1 6 SGSLDDSFSDFQELPASSK 19 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.001)GS(0.001)LDDS(0.926)FS(0.072)DFQELPASSK;SGSLDDS(0.995)FS(0.005)DFQELPASSK;S(0.044)GS(0.254)LDDS(0.701)FSDFQELPASSK;SGSLDDS(0.579)FS(0.421)DFQELPASSK;SGSLDDS(0.995)FS(0.005)DFQELPASSK;SGSLDDS(0.995)FS(0.005)DFQELPASSK 259.55 3.5075999999999984e-95 9859200.0 6293.53 7163.1 8260.26 8071.85 7004.429999999999 7200.97 6846.22 6810.86 3824.49 5996.13 True False 6440.1570039223825 6324.440921965157 7138.562062360321 6662.252924890338 6370.880543232556 7128.534779757632 6329.804113476655 6630.2138680088 6489.880200302175 6765.7916927522065 0.9518704235043687 0.9347673131497911 1.0550963414979864 0.9846967254441512 0.9416311989116225 1.0536142854344763 0.9355600055286066 0.9799612771276061 0.959219629427019 1.0 12.724043044345033 SGSLDDS(ph)FSDFQELPASSK ddPTM_A459_Selumetinib_30min_R2 7 SGSLDDSFSDFQELPASSK 19 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 SGS(0.001)LDDS(0.997)FS(0.002)DFQELPASSK;SGSLDDS(1)FSDFQELPASSK;SGSLDDS(0.993)FS(0.006)DFQELPASSK;S(0.002)GS(0.002)LDDS(0.794)FS(0.202)DFQELPASSK;SGS(0.001)LDDS(0.992)FS(0.007)DFQELPASSK;S(0.076)GS(0.076)LDDS(0.807)FS(0.041)DFQELPASSK;S(0.301)GS(0.301)LDDS(0.398)FS(0.001)DFQELPASSK 180.62 1.2618e-10 0.0 44847.4 39794.200000000004 45751.899999999994 50914.0 50567.3 38253.0 40456.5 39645.90000000001 33579.1 44608.3 True False 42354.96104636662 42846.287181479514 42808.272564902276 43979.4253684511 44214.58369660228 43522.00352383979 42337.807413033916 39761.26300526793 40295.85827844544 43320.34247271747 0.9777152863701658 0.9890569819124465 0.988179458457936 1.0152141663272563 1.0206425243394137 1.0046551121161917 0.9773193145852357 0.9178427670628182 0.9301832806105629 1.0 15.402757027891306 -7.552054244055973 5.342787192332419 0.9431450516942599 0.9994207569446036 0.4706087083032877 0.023422376859316366 0.14183230276601938 11.051847490608367 0.011181804059975597 0.00648731101320183 2.80508325681085e-08 7.552054244055973 0.056275705250343755 SGSLDSELS(ph)VSPK ddPTM_A459_Selumetinib_30min_R1 1 SGSLDSELSVSPK 13 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 SGSLDSELS(0.905)VS(0.095)PK 170.26 0.00023238 7766300.0 2084.1 2596.0 3016.2 2535.6 1856.5 2269.2 2030.4 2224.8 1660.2 2365.7 True False 2132.6554750473324 2292.059113152343 2606.616606800659 2092.805059106891 1688.5799027916958 2246.373908268751 1877.2452933155826 2165.7910768311167 2817.238143789547 2669.3606388693856 0.7989386836656975 0.8586547204513926 0.9764947339242621 0.7840098593771517 0.6325784078043865 0.8415400585288499 0.7032565274172524 0.811351993917331 1.0553980989930214 1.0 11.382278515867073 -8.254730671084378 22.14955293322554 1.027699098994709 0.8005669344692391 0.52125054605764 0.08696011858244239 84.24337994174961 278151.4767928549 0.06684025149066428 0.02377358915567801 5.562491097417388e-09 8.254730671084378 -0.22713216452546992 SGSLDSELS(ph)VSPKR ddPTM_A459_Selumetinib_30min_R1 1 SGSLDSELSVSPKR 14 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 SGSLDS(0.007)ELS(0.916)VS(0.077)PKR 136.14 0.0010731 22345000.0 2894.6 2780.2 4852.9 5145.0 3688.1 3699.3 3180.2 3255.1 1780.3 2690.6 True False 2962.0385480888644 2454.6928915200842 4193.902835071586 4246.522333611353 3354.5120061869393 3662.08840069566 2940.314953606292 3168.764173945058 3021.0390720326027 3035.9647186633842 0.9756498584716536 0.808538016410411 1.3814069739644395 1.3987390260190276 1.1049245683144167 1.2062354935099289 0.9684944411675498 1.043742094387757 0.9950837219750852 1.0 11.56793930976819 -7.265991154476613 24.190954187454174 1.0054752338680524 1.1509132004050557 0.154948972731908 0.16450788472240807 559.200151938633 2971913.9803752354 0.07455150348281207 0.05221813840613938 5.4201192975527824e-08 7.265991154476613 0.14543796653700336 SGSLDSELSVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 SGSLDSELSVSPK 13 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 SGSLDS(0.005)ELS(0.177)VS(0.817)PK;SGSLDSELS(0.003)VS(0.997)PK;SGSLDSELS(0.002)VS(0.998)PK 206.66 1.2026e-05 281820000.0 11725.2 14485.4 15063.699999999999 14314.199999999999 10851.9 11251.500000000002 11183.2 11560.4 8275.45 12606.1 True False 11998.374346732384 12789.442633920236 13018.132278981195 11814.493680812373 9870.34756105855 11138.320125544615 10339.642220354022 11253.780638528608 14042.834235045897 14224.21572881234 0.8435174617345456 0.8991316553231227 0.9152091424353104 0.8305901644110422 0.6939115483931627 0.7830533744635927 0.7269042045959843 0.7911705540104494 0.9872484010911731 1.0 13.796061489350553 -8.266627870030263 23.099230111049764 0.9936243275228439 0.80997547549766 0.5604757064434949 0.06488788694789353 134.94969631867633 600767.9583503429 0.064625551674679 0.018804229524154982 5.4121787276326034e-09 8.266627870030263 -0.18364885202518388 SGSLDSELSVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 SGSLDSELSVSPK 13 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 SGSLDSELS(0.001)VS(0.999)PK;SGSLDSELS(0.006)VS(0.994)PK;SGSLDSELS(0.009)VS(0.991)PK;SGSLDS(0.006)ELS(0.069)VS(0.925)PK 181.75 0.00010861 129226300.0 327665.0 261861.0 296952.0 281767.0 259429.0 229495.0 305990.0 270512.0 194987.4 237668.0 True False 309454.69104692177 281944.8966841756 277846.431616892 243389.84852481406 226837.20969531353 261105.85310181195 320219.1413076822 271299.1451343278 233990.32840316047 230805.90730437686 1.3407572391066502 1.2215670732914077 1.2038098801798869 1.0545217467239347 0.9828050431836236 1.1312789007496105 1.3873957778965815 1.175442813846832 1.013796965320234 1.0 17.81632062359207 SGSLDSELSVS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 2 SGSLDSELSVSPKR 14 1 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 SGSLDSELS(0.052)VS(0.948)PKR;SGSLDSELS(0.027)VS(0.973)PKR 204.17 4.8235e-05 56800000.0 7352.6 7622.0 11292.1 11972.900000000001 8751.2 7754.9 7332.200000000001 7473.700000000001 4774.6 6231.6 True False 7523.901274330893 6729.612696628331 9758.694843065354 9882.057774168201 7959.655505149849 7676.892746885829 6779.126250811913 7275.473198001038 8102.147477013352 7031.486560924233 1.0700299586922535 0.9570682725935235 1.3878565732169514 1.405400933151934 1.1320018087474828 1.0917880138672642 0.9641099633874364 1.0346991542915975 1.1522666518398903 1.0 12.779614013412457 -6.712635840440962 3.2526770512704424 1.0421943673384004 1.205622283339477 0.23316407354733937 0.13286333494706604 0.40352047176548644 8.720623783472647 0.05258166688720341 0.05040861897529704 1.9380463509111786e-07 6.712635840440962 0.16342791600107653 SGSLGQPSPS(ph)AQR ddPTM_A459_Selumetinib_30min_R1 1 SGSLGQPSPSAQR 13 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 S(0.008)GS(0.012)LGQPS(0.22)PS(0.76)AQR 94.339 0.015911 5938100.0 1250.6 1746.3 1739.4 1910.1 1869.0 1352.1 1692.2 1962.0 879.08 1415.0 True False 1279.7365467560055 1541.8423841671558 1503.1990338402836 1576.5368920176954 1699.949279998751 1338.4991016085742 1564.5559916019643 1909.961386525823 1491.734554537112 1596.6290332671845 0.8015240360105933 0.9656860498221564 0.9414829634935832 0.9874158988526129 1.0647114918862162 0.8383281737459085 0.9799120265277971 1.1962461828828617 0.9343025358148306 1.0 10.640813435210113 -3.799977397046375 0.8828804013496516 1.0038249774487504 2.3579210608571897e-17 0.2980444622483043 0.0875831490654449 14.255090041724298 2.3681411098597738 0.030528222778086932 20.807399978424208 0.0001584975680728991 3.799977397046375 -1.0038249774487504 SGSMEEDVDTS(ph)PGGDYYTSPS(ph)SPTSSSR ddPTM_A459_Selumetinib_30min_R1 1 SGSMEEDVDTSPGGDYYTSPSSPTSSSR 28 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 2 SGSMEEDVDT(0.201)S(0.798)PGGDYYT(0.021)S(0.078)PS(0.528)S(0.332)PT(0.031)S(0.008)S(0.002)SR 107.89 3.657e-09 2320700.0 903.97 982.31 899.11 996.64 869.49 739.62 1025.7 866.57 452.62 765.54 True False 925.0307421805752 867.3006885364704 777.015800457709 822.595533249839 790.844783020928 732.1800943212294 948.3306232041929 843.5857485839357 768.0630819431542 863.8045159910678 1.0708797245859045 1.004047411747311 0.8995273653625397 0.9522936243347275 0.9155367544166738 0.8476224432343678 1.0978532823669553 0.9765933529718417 0.88916307766918 1.0 9.75456104878422 -4.9574895902958 3.742336191862961 0.9472772382492739 1.0669165599910297 0.2585698245764575 0.0656708842949397 0.3242062538731381 9.235896400095887 0.017120888525510886 0.08303255998280677 1.1028346676302372e-05 4.9574895902958 0.11963932174175584 SGSMEEDVDTSPGGDYYTSPS(ph)SPTSSSR ddPTM_A459_Selumetinib_30min_R1 2 SGSMEEDVDTSPGGDYYTSPSSPTSSSR 28 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 SGSMEEDVDTSPGGDYYTSPS(0.442)S(0.442)PT(0.079)S(0.026)S(0.009)S(0.002)R;SGSMEEDVDTSPGGDYYTSPS(0.76)S(0.156)PT(0.055)S(0.02)S(0.007)S(0.002)R 221.37 3.6623e-45 23653000.0 3261.8999999999996 4067.8999999999996 4267.9 4882.7 4363.4 4043.6 3953.0 3836.3 2058.44 3589.1 True False 3337.895923447477 3591.628376884598 3688.342621896602 4030.0281046305467 3968.7312404208374 4002.925055295047 3654.8220274214436 3734.5488619413945 3493.0223374907546 4049.7959457945253 0.8242133599135248 0.8868665051172004 0.9107477688417187 0.9951188056315513 0.9799830148336562 0.9884263574938508 0.9024706618161247 0.9221572918555325 0.8625181081328437 1.0 11.983633502435461 -5.026051547540208 1.7932684465932414 0.946970337333761 0.8160178938031271 0.45254411514732906 0.04299841646564979 0.5425420626283772 2.5415849762372282 0.012849766980794573 0.1030638794457374 9.417778078342948e-06 5.026051547540208 -0.13095244353063396 SGSMEEDVDTSPGGDYYTSPS(ph)SPTSSSR ddPTM_A459_Selumetinib_30min_R2 2 SGSMEEDVDTSPGGDYYTSPSSPTSSSR 28 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 SGSMEEDVDTSPGGDYYTSPS(0.404)S(0.404)PT(0.132)S(0.043)S(0.014)S(0.002)R;SGSMEEDVDTSPGGDYYTSPS(0.778)S(0.147)PT(0.05)S(0.017)S(0.006)S(0.001)R 233.21 1.3321e-49 9941800.0 110623.0 96874.0 111282.0 116383.0 129745.0 96298.0 102205.0 114656.0 87288.0 109731.0 True False 104475.01651895579 104303.92430099472 104122.23727468043 100531.43462812687 113445.27316498318 109562.175393792 106957.73501536534 114989.62997767751 104748.03903049654 106562.78091462266 0.9804081276994866 0.9788025744613617 0.9770975980638346 0.9434010051658837 1.0645862672810193 1.0281467361627175 1.0037063043714964 1.0790787270257745 0.9829702090302984 1.0 16.70134411172763 -6.256883484689874 24.99888071058809 1.029319824987173 0.9710734350777993 0.47703676486377944 0.028868616240654826 326.27713654462855 1790331.3458782444 0.008215768131685501 0.01026758499010717 5.534985854496305e-07 6.256883484689874 -0.058246389909373586 SGSNGGGQAPGASPS(ph)VSLPASLGR ddPTM_A459_Selumetinib_30min_R2 2 SGSNGGGQAPGASPSVSLPASLGR 24 0 P38432 P38432 COIL Coilin 1 SGSNGGGQAPGAS(0.042)PS(0.947)VS(0.012)LPASLGR;SGSNGGGQAPGAS(0.143)PS(0.829)VS(0.028)LPASLGR 181.81 1.9267e-20 6383500.0 38735.0 34903.0 40437.0 48960.0 50628.0 30438.0 37398.0 44670.0 30376.9 41475.0 True False 36582.26376849071 37579.94786916637 37835.32744447669 42291.56353928913 44267.65801993738 34630.55821134643 39137.08110273115 44799.9823044834 36453.12880150179 40277.50898500854 0.9082553685757175 0.9330256218961749 0.9393661226308497 1.0500044467752518 1.099066430260471 0.8597989072322241 0.9716857394854815 1.112282845524487 0.9050492376544389 1.0 15.29768684029972 -5.6070594408809535 7.339953736483694 1.001413347333658 0.9244492884680345 0.17116583608380886 0.07400081221619004 0.39878983471480756 29.291702705210316 0.020444730226554613 0.035592009449648895 2.4713858690010436e-06 5.6070594408809535 -0.07696405886562341 SGSPRPT(ph)EPTDFLMLFEGSPSGK ddPTM_A459_Selumetinib_30min_R1 2 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.023)GS(0.025)PRPT(0.754)EPT(0.198)DFLMLFEGSPSGK;S(0.079)GS(0.349)PRPT(0.422)EPT(0.15)DFLMLFEGSPSGK 68.291 0.0051056 23514000.0 4415.7 5123.1 5524.3 5904.5 5071.1 4918.4 5264.9 4595.3 3149.5 4586.0 True False 4518.577218543498 4523.285070335428 4774.1304028077975 4873.389916192079 4612.419900375426 4868.925361549891 4867.764354204691 4473.417716361933 5344.471469621235 5174.657771422833 0.8732127646194198 0.8741225545997213 0.9225982883685647 0.9417801391824377 0.8913478154724783 0.9409173662534058 0.9406930021705071 0.8644857136382015 1.0328164113839957 1.0 12.337247737071662 -1.5228787466232843 0.04371172286098246 1.2054344081630237 0.44445290125670905 0.4442050768448549 0.039448322656480635 625.0879348710885 2.0821270324764183 9.401162679050994 33.907560692469595 0.029999999907232528 1.5228787466232843 -0.7609815069063146 SGSPRPTEPTDFLMLFEGS(ph)PSGK ddPTM_A459_Selumetinib_30min_R1 1 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 SGSPRPTEPTDFLMLFEGS(0.926)PS(0.074)GK 66.372 0.0074602 2538200.0 961.42 937.16 1155.9 955.47 1089.8 852.18 978.8 802.64 502.13 717.29 True False 983.8192154023338 827.4368715261359 998.9351289042106 788.6151008932243 991.2277824198169 843.6078429175316 904.9683279635989 781.3513798578422 852.0779358758249 809.3611584962684 1.2155503202429372 1.0223333092280469 1.2342266717619068 0.9743673669223406 1.224703918657825 1.042313229467165 1.118126708285534 0.9653927318547553 1.0527783881535915 1.0 9.660639805041765 -7.748478949676224 24.84475196187057 1.0068141753366997 1.1151080612537467 0.26468955260128213 0.08595773650198069 265.20872735677193 508399.31712710456 0.037084629917680335 0.021235727672477372 1.7845184823436116e-08 7.748478949676224 0.10829388591704703 SGSPRPTEPTDFLMLFEGSPSGK ddPTM_A459_Selumetinib_30min_R1 1 SGSPRPTEPTDFLMLFEGSPSGK 23 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 0 91.774 0.00037563 6583200.0 1663.3 2005.6 1917.4 2438.5 1930.9 1630.4 1902.5 1683.4 1028.5 1437.6 False True 1702.051653781598 1770.7834196218562 1657.0276115242973 2012.6617513141473 1756.2504359280842 1613.9996562847577 1758.992893288462 1638.7507635461618 1745.2893813320966 1622.1299634098277 1.0492695974888284 1.0916409039751345 1.0215134723491035 1.240752465408749 1.0826817058704261 0.9949878817921719 1.0843723579280535 1.0102462814393713 1.075924507098913 1.0 10.663673696113449 -6.5377769597425655 23.68409084751798 1.0371600328625898 1.1028823568923776 0.22335589522091548 0.060203950795266116 204.21046955571154 324634.593119233 0.019782158656559783 0.019791628729589648 2.8988319562057635e-07 6.5377769597425655 0.06572232402978773 SGSPSDNS(ph)GAEEMEVSLAKPK ddPTM_A459_Selumetinib_30min_R1 1 SGSPSDNSGAEEMEVSLAKPK 21 1 P31749-2;P31749 P31749-2 AKT1 RAC-alpha serine/threonine-protein kinase 1 S(0.015)GS(0.052)PS(0.186)DNS(0.747)GAEEMEVSLAKPK 121.84 0.0010414 0.0 1277.3 1232.8 1209.7 1250.2 1076.0 1077.0 1151.6 1072.1 597.2 997.84 True False 1307.0586048068496 1088.4632028868284 1045.4293844064582 1031.8760391605276 978.6759899832288 1066.1663578377595 1064.7338848415206 1043.6644253284067 1013.4047822377528 1125.9224837846843 1.1608779677383234 0.9667301422279623 0.9285091997562248 0.9164716523751899 0.8692214642463661 0.946926962728322 0.9456546966381878 0.9269416326248545 0.9000662095593707 1.0 10.136891790491433 -4.72975231092888 2.6866151497235813 0.92550058321787 1.2270001702089668 0.8215176069582576 0.03218475003737462 0.21732192880623397 1.842369244603847 0.008104275442402262 0.15705176103770233 1.8631494347111987e-05 4.72975231092888 0.3014995869910968 SGSPSDNS(ph)GAEEMEVSLAKPK ddPTM_A459_Selumetinib_30min_R2 3 SGSPSDNSGAEEMEVSLAKPK 21 1 P31749-2;P31749 P31749-2 AKT1 RAC-alpha serine/threonine-protein kinase 1 S(0.001)GS(0.004)PS(0.01)DNS(0.985)GAEEMEVSLAKPK;S(0.006)GS(0.036)PS(0.189)DNS(0.768)GAEEMEVSLAKPK;S(0.008)GS(0.035)PS(0.049)DNS(0.908)GAEEMEVSLAKPK 92.819 0.00030887 28805000.0 68632.0 53307.0 60057.0 68835.0 66753.0 52607.0 52882.0 60034.0 42173.0 57011.0 True False 64817.7081956642 57395.47549097928 56192.99800511749 59459.55425300176 58366.89136060836 59853.13673120114 55341.11778369507 60208.689000836246 50608.77841207415 55364.94429763284 1.1707355442681358 1.0366753948569087 1.0149562817770243 1.0739567249152635 1.0542210798016438 1.081065600092371 0.999569646204109 1.087487574757851 0.914094271277682 1.0 15.75668516636728 -1.5228787452803376 0.20028555760652858 0.9908712867584102 1.5580608354133785 0.3428662855725364 0.05253927996787493 71.73130048100548 0.8674381607045469 0.09536052270478035 12.772405988247979 0.029999999999999995 1.5228787452803376 0.5671895486549683 SGSS(ph)PGLR ddPTM_A459_Selumetinib_30min_R1 3 SGSSPGLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.002)GS(0.126)S(0.873)PGLR;S(0.004)GS(0.331)S(0.665)PGLR;S(0.032)GS(0.132)S(0.836)PGLR 131.62 0.0035228 74998500.0 8289.3 10011.7 10556.6 9455.9 9807.9 9851.0 9129.5 9538.3 7134.299999999999 8282.5 True False 8482.424561829968 8839.52550968694 9123.071703253043 7804.604574226553 8920.777176725385 9751.907883992357 8440.854464797378 9285.313299235095 12106.386031344266 9345.639553381947 0.9076344656113339 0.9458449000944128 0.9761848454717728 0.8351065253102199 0.9545389725090762 1.0434714316007825 0.9031863915340977 0.993544983860947 1.2954047673455666 1.0 13.190077680459245 -8.052130096490718 8.937089905846316 1.1475401170200266 0.9410193783982314 0.49663875675832003 0.08326983453405001 0.33590113930324583 54.64669820805439 0.05260716947925191 0.019979120323308026 8.868902969447919e-09 8.052130096490718 -0.2065207386217952 SGSS(ph)PGLR ddPTM_A459_Selumetinib_30min_R2 1 SGSSPGLR 8 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.015)GS(0.339)S(0.646)PGLR 109.48 0.012433 6934300.0 13586.0 13410.0 13285.0 14748.0 16153.0 11643.0 19658.0 21364.0 22817.0 22955.0 True False 12830.94450906712 14438.503880053884 12430.25756361433 12739.29695828096 14123.715730347805 13246.717565369165 20572.135951588014 21426.165702999402 27381.037560246987 22292.229505747353 0.5755792396520528 0.6476922317855811 0.5576049520039966 0.5714680514569677 0.6335712507672886 0.5942302703259857 0.9228388729034094 0.9611495206199693 1.2282772144072733 1.0 14.444253291168861 -7.47135692355526 1.744175116285158 1.0935259642339292 0.5905414278099507 0.9057968173777261 0.06928653250470833 0.09652137215132238 0.5726123797866285 0.040101790247421255 0.020688423430607526 3.377871128213311e-08 7.47135692355526 -0.5029845364239786 SGSS(ph)QELDVKPSASPQER ddPTM_A459_Selumetinib_30min_R2 2 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SGS(0.002)S(0.997)QELDVKPSASPQER;S(0.088)GS(0.239)S(0.673)QELDVKPSASPQER 204.63 2.4445e-10 56519000.0 49789.0 45183.0 43100.0 40824.0 47500.0 34088.0 35703.0 37592.0 33290.1 44788.0 True False 47021.92670115875 48648.39081375653 40326.99292373186 35263.70077467197 41532.62534461221 38783.312579945385 37363.26024415236 37701.3864963094 39949.05020311074 43494.85406680081 1.0810917224584993 1.1184861257159466 0.9271669899569349 0.8107556981456433 0.9548859568726233 0.8916758869998899 0.8590271434585951 0.8668010803854264 0.918477623623146 1.0 15.408557103465707 -5.321212631075815 4.775564839528937 0.893565633702154 1.1004877341734396 0.7058055744490113 0.05061675917353255 0.09289775099029417 4.385583151289306 0.01268438861431131 0.028376720306928855 4.772955320030687e-06 5.321212631075815 0.20692210047128556 SGSS(ph)SPDSEITELK ddPTM_A459_Selumetinib_30min_R1 1 SGSSSPDSEITELK 14 0 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.002)GS(0.041)S(0.795)S(0.163)PDSEITELK 322.18 1.4588999999999992e-109 66093000.0 10808.0 13639.0 7642.8 7819.7 8378.5 9420.0 10541.0 9571.8 5076.8 8693.7 True False 11059.805371292918 12042.139539400916 6604.949738895327 6454.136188948626 7620.666154344316 9325.24335267567 9745.883883392215 9317.924770411755 8614.958805198628 9809.621078809138 1.1274447078475278 1.2275845766779403 0.6733134425715402 0.6579393981782772 0.776856322290223 0.9506221777332637 0.993502583340899 0.9498761160653239 0.8782152476621923 1.0 13.259981694472451 -5.246179450966637 24.983400619249036 0.8560633003798666 1.1775146924579496 0.5319533532575855 0.11907083386026869 682.9228294272475 1118070.1043886845 0.034123083444749666 0.08953927603884079 5.6731014378478274e-06 5.246179450966637 0.32145139207808304 SGSS(ph)SPDSEITELK ddPTM_A459_Selumetinib_30min_R2 1 SGSSSPDSEITELK 14 0 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.006)GS(0.047)S(0.9)S(0.047)PDSEITELK 329.46 2.0871999999999992e-126 95253000.0 125330.0 98788.0 117380.0 146710.0 136070.0 123080.0 156580.0 143430.0 117560.0 106910.0 True False 118364.66033574136 106364.7219465149 109827.89859368115 126727.84491113365 118975.67011876582 140033.1527910021 163861.28025738377 143847.3575538851 141075.28490084715 103823.2305144611 1.1400595006457137 1.0244790247756719 1.0578354964439647 1.2206116519701462 1.1459445976514302 1.3487651279690962 1.5782718322809288 1.3855026167178375 1.3588026899355379 1.0 16.663769758193105 -6.7357367885734565 3.625429514919838 1.3766854676175027 1.10956972626761 0.34774265073286437 0.14357420268509927 0.2184528536315274 6.064847051163605 0.04972398916458428 0.04718306810025857 1.837651745458392e-07 6.7357367885734565 -0.2671157413498926 SGSS(ph)SPDSEITELKFPSINHD ddPTM_A459_Selumetinib_30min_R1 1 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.103)GS(0.103)S(0.394)S(0.394)PDS(0.007)EITELKFPSINHD 104.97 8.2619e-05 319450000.0 742.36 956.53 1006.5 865.71 898.16 864.95 962.22 818.0 291.29 864.67 True False 759.6555436188937 844.5390229212676 869.8228283087534 714.5299998893462 816.9215865830273 856.2493883117647 889.638970712234 796.3039827615307 494.29785502015244 975.6588170990367 0.7786077779500895 0.865608969160313 0.8915235665014851 0.7323564214936173 0.8373025203749106 0.8776114901084823 0.9118340910990086 0.8161705391329436 0.506629824234938 1.0 9.930232922672376 -10.9176087180705 5.32359577233672 1.0001131049339897 0.8113336234717075 0.21671571969898074 0.11167806576861139 0.00015032854533616877 1.7091783875864666e-05 0.1084273109157183 0.026281780507289614 1.2089025173406983e-11 10.9176087180705 -0.1887794814622823 SGSS(ph)SPDSEITELKFPSINHD ddPTM_A459_Selumetinib_30min_R2 2 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.124)GS(0.096)S(0.437)S(0.34)PDS(0.003)EITELKFPSINHD;S(0.018)GS(0.083)S(0.382)S(0.279)PDS(0.238)EITELKFPSINHD 162.82 2.8074e-08 131088000.0 139255.0 131084.0 179091.0 232303.0 262679.0 144388.0 136772.0 139580.0 134856.0 196558.0 True False 131515.76458193298 141137.7212985076 167568.48003953745 200662.9306549727 229678.915639945 164276.13637623636 143132.16900857663 139986.15469128697 161830.96819146513 190882.859820984 0.6889867676190131 0.7393944193358745 0.8778602761750766 1.0512359823357673 1.203245361345409 0.860612296621602 0.7498429620281806 0.733361574855754 0.84780251272029 1.0 17.542328037307257 -5.252827867121016 3.5230054121660515 0.9149930090551478 0.7033908334827994 0.273372052697592 0.13318001294659668 0.36077456288046494 9.671178461151687 0.040968069969787274 0.11410620668347984 5.586915886061447e-06 5.252827867121016 -0.2116021755723484 SGSSFVHQAS(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 SGSSFVHQASFK 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 SGSSFVHQAS(1)FK 121.76 0.0027901 0.0 1697.2 1106.4 1413.2 1638.5 1592.6 1495.1 1877.8 1586.0 477.98 1243.1 True False 1736.7414578236796 976.8621736485941 1221.2952021519436 1352.3667334542677 1448.5496111963666 1480.0606514421863 1736.1560341745471 1543.9341279459513 811.0971497220376 1402.6639938193905 1.238173550812131 0.6964334851061819 0.8706969078363608 0.9641416186722198 1.0327131925957775 1.05517833063644 1.237756185247953 1.1007155917233526 0.5782547732714353 1.0 10.453953739445302 -4.6717232783321085 22.390330869408913 0.9646523541493801 1.2382953913447594 0.17831609806247395 0.18364311556371016 111893.99643188079 27890514.85316939 0.04732247915688712 1948.8444740537138 2.1294954754738553e-05 4.6717232783321085 0.2736430371953793 SGSSFVHQAS(ph)FK ddPTM_A459_Selumetinib_30min_R2 1 SGSSFVHQASFK 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 SGSSFVHQAS(1)FK 105.03 0.011209 0.0 6358.9 5771.6 8344.6 9104.8 8542.1 8121.4 4837.4 5376.7 6713.7 9056.3 True False 6005.497794693572 6214.263161380986 7807.7175209135285 7864.710533343946 7468.965030657091 9240.049131271075 5062.348685126252 5392.3453068394 8056.627596451341 8794.82108790676 0.6828447940744785 0.706582100905481 0.8877630872616 0.894243379681509 0.8492458181926208 1.050623888640159 0.5756056472924946 0.6131273453935404 0.916064979142047 1.0 13.10243851406881 -12.384842339562928 1.1294836092192986 2.9083026108067216 0.7972088287541631 0.1541076896255541 0.1424587048038781 107678.26654343893 3721.6070376809785 520329.9032485238 0.04439713647168548 4.1224714860518295e-13 12.384842339562928 -2.1110937820525586 SGSSQELDVKPS(ph)ASPQER ddPTM_A459_Selumetinib_30min_R1 1 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.007)GS(0.029)S(0.166)QELDVKPS(0.773)AS(0.026)PQER 120.99 0.004468 9905900.0 2136.6 2162.6 2598.5 2610.4 2275.5 2093.5 2263.1 2313.0 1287.3 1896.6 True False 2186.378622900114 1909.4017866345355 2245.637972538795 2154.5426432767877 2069.681426772154 2072.441290745915 2092.392544967737 2251.6517263171404 2184.4540793279616 2140.0470844484403 1.021649775272872 0.8922241947431967 1.0493404508983357 1.006773476590158 0.9671195749908362 0.9684092026788516 0.9777320135491387 1.0521505543872014 1.020750475633094 1.0 11.063426823229161 -7.74436873548527 24.815494360876905 1.027337887335187 0.98206202834702 0.1735388262205586 0.04075526745050498 337.7571679247375 490996.98825830896 0.018889733812302054 0.010870362699204881 1.8014875476585747e-08 7.74436873548527 -0.045275858988166995 SGSSQELDVKPS(ph)ASPQER ddPTM_A459_Selumetinib_30min_R2 1 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SGSSQELDVKPS(0.769)AS(0.231)PQER 72.207 0.011135 60186000.0 162590.0 124220.0 131130.0 146040.0 149300.0 123690.0 161450.0 169160.0 124940.0 139760.0 True False 153553.89869933928 133747.27456974573 122693.23856354872 126149.10006694785 130543.59924106514 140727.17475397332 168957.7449071058 169652.2275940546 149931.49111527606 135724.765659911 1.1313624153465343 0.9854301381140689 0.9039856356870365 0.929447912130074 0.9618259321085995 1.0368570103601946 1.2448556760117568 1.2499725217367956 1.1046730520129482 1.0 17.050324467373258 -7.06962157138569 4.778184811379585 1.1696800218245866 0.9768472102689942 0.4407881988351692 0.08778412727554866 0.18380323561194364 7.997663197326594 0.03440899499389108 0.026865379093846464 8.518800125391051e-08 7.06962157138569 -0.1928328115555924 SGSSQELDVKPSAS(ph)PQER ddPTM_A459_Selumetinib_30min_R1 2 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SGSSQELDVKPS(0.083)AS(0.917)PQER;SGSSQELDVKPS(0.302)AS(0.698)PQER 206.45 9.3994e-11 38711400.0 5628.4 5769.8 5584.7 6444.0 6232.6 5327.4 6708.400000000001 6236.200000000001 3067.71 6000.7 True False 5759.530769040067 5094.269133692751 4826.328414561247 5318.676368861333 5668.862430454907 5273.8111928921835 6202.379987036178 6070.795717967554 5205.679813326484 6770.9482967677695 0.8506239475775468 0.7523715896818455 0.7127994784519591 0.7855142493704015 0.837233158782358 0.7788881205029625 0.9160282600292476 0.8965946056426918 0.768825810678765 1.0 12.72514218747797 -6.985029281971161 1.1232001013204875 0.8901068935942581 0.7711811937314631 0.37057543295041817 0.066049093161578 0.5623707289016576 1.4621465428209264 0.038906818617628805 0.028330339063041523 1.0350723753683551e-07 6.985029281971161 -0.118925699862795 SGSSQELDVKPSAS(ph)PQER ddPTM_A459_Selumetinib_30min_R2 1 SGSSQELDVKPSASPQER 18 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SGSSQELDVKPS(0.166)AS(0.834)PQER 105.38 0.00095459 52912000.0 65644.0 66894.0 71670.0 82446.0 81383.0 60165.0 86413.0 78343.0 76607.0 66093.0 True False 61995.76927375258 72024.55470188856 67058.83022839582 71216.71257271718 71158.9399667489 68452.18262650813 90431.37572411115 78570.9651596182 91930.5405784215 64184.72335976308 0.9658960267890982 1.1221448178281035 1.044778675020893 1.1095586121566492 1.108658513146415 1.0664871490187071 1.4089236657955575 1.2241380977716225 1.432280701174636 1.0 15.969942341138092 -7.2394124547391625 24.422212062511353 1.2850137880486547 1.0744414294102658 0.395953230148565 0.11806134598657399 530.8239628100827 588548.2997425535 0.04152154348880448 0.03213227390045058 5.762189613093605e-08 7.2394124547391625 -0.21057235863838897 SGSSS(ph)PDSEITELK ddPTM_A459_Selumetinib_30min_R1 3 SGSSSPDSEITELK 14 0 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 SGS(0.003)S(0.054)S(0.943)PDSEITELK;SGSS(0.02)S(0.98)PDSEITELK;SGS(0.001)S(0.468)S(0.53)PDS(0.001)EITELK 312.91 3.817099999999998e-94 217091000.0 25033.3 31230.1 18606.5 18781.0 18583.399999999998 21176.3 24390.1 22538.5 12556.400000000001 21706.2 True False 25616.527183677543 27573.66537352041 16079.839498188598 15501.250913033009 16902.53475116575 20963.285648542 22550.33512041782 21940.705764634164 21307.293716828735 24492.402206292718 1.0458968854062018 1.1258048574114972 0.6565235766893164 0.6329003901891807 0.6901133914427986 0.8559097418037666 0.9207073659203616 0.8958168161633832 0.8699552431551345 1.0 14.580046659418887 -9.560980663303951 18.119558258331647 0.999999999977354 0.8487841431583065 0.07427144753486459 0.15238905763880278 0.0 0.0 0.1645216868352941 0.0399023701486299 2.748016504131827e-10 9.560980663303951 -0.15121585681904748 SGSSS(ph)PDSEITELK ddPTM_A459_Selumetinib_30min_R2 3 SGSSSPDSEITELK 14 0 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 SGS(0.007)S(0.113)S(0.809)PDS(0.071)EIT(0.001)ELK;SGS(0.003)S(0.049)S(0.948)PDSEITELK;S(0.001)GS(0.004)S(0.034)S(0.961)PDS(0.001)EITELK 162.67 0.00027391 113802900.0 174082.0 149463.0 170660.0 185324.0 189820.0 154993.0 212590.0 200487.0 182045.0 148081.0 True False 164407.21934546024 160926.33150070827 159679.92140055908 160082.55149826859 165973.114587669 176341.87886363151 222475.8562390934 201070.3839775904 218459.08676228984 143805.51676935636 1.1432608639705115 1.1190553402677261 1.1103880086649458 1.1131878323904518 1.1541498429011339 1.2262525306762666 1.5470606499465045 1.398210503287428 1.5191286931826629 1.0 17.13375949696733 -7.031329398790766 4.587564960198295 1.4000168414342804 1.1294888014227162 0.3788354758297555 0.1407166846018686 0.18126381796667582 9.155625690751007 0.05037186160882529 0.04035305258721256 9.304019269995821e-08 7.031329398790766 -0.27052804001156416 SGSSS(ph)PDSEITELKFPSINHD ddPTM_A459_Selumetinib_30min_R1 4 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.042)GS(0.055)S(0.186)S(0.539)PDS(0.17)EIT(0.007)ELKFPSINHD;S(0.035)GS(0.035)S(0.161)S(0.765)PDS(0.005)EITELKFPSINHD;S(0.009)GS(0.038)S(0.169)S(0.77)PDS(0.015)EITELKFPSINHD;S(0.041)GS(0.028)S(0.147)S(0.779)PDS(0.005)EITELKFPSINHD 232.58 2.1091e-25 641231000.0 15372.8 14258.5 17652.4 18433.9 19697.8 15475.2 16770.6 13957.8 5019.91 9313.9 True False 15730.956329738307 12589.108191403178 15255.301037692452 15214.765412159053 17916.13746792905 15319.533538357386 15505.580139912472 13587.593802675898 8518.42063027983 10509.429790068716 1.496842040336372 1.1978868923316595 1.4515821830893743 1.447725111265011 1.704767796713346 1.4576940751661103 1.4753969006544063 1.2928954352514928 0.8105502201774671 1.0 13.359396774695718 -8.099072695888449 3.6053565022819356 0.9098293303635485 1.4574937026705375 0.7592668849609386 0.12332769837681856 0.12246219858946356 2.820359961628436 0.09985001636602467 0.034200767049431785 7.960260936756537e-09 8.099072695888449 0.547664372306989 SGSSS(ph)PDSEITELKFPSINHD ddPTM_A459_Selumetinib_30min_R2 4 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.033)GS(0.033)S(0.158)S(0.767)PDS(0.009)EITELKFPSINHD;S(0.067)GS(0.067)S(0.276)S(0.527)PDS(0.062)EITELKFPSINHD;S(0.042)GS(0.042)S(0.156)S(0.594)PDS(0.166)EITELKFPSINHD;S(0.043)GS(0.033)S(0.139)S(0.598)PDS(0.183)EIT(0.003)ELKFPSINHD 129.74 3.0305e-05 144541900.0 83875.0 87395.0 106875.0 139899.0 155960.0 97896.0 86102.0 94906.0 87761.0 123775.0 True False 79213.56327822791 94097.91548078376 99998.77885670186 120844.5148607641 136366.9104999097 111380.28538859224 90105.9136078762 95182.16074746584 105315.65224722099 120201.29414392854 0.6590075742726856 0.7828361262742422 0.8319276391231174 1.0053511962696955 1.13448787278966 0.926614693975141 0.7496251537856468 0.7918563724737865 0.8761607185453133 1.0 16.87509290330602 -5.110936912054005 1.9197899504439018 0.9166816385290782 0.6604956707497577 0.385478760998865 0.10582650253591311 0.5553689189620106 3.333504961623895 0.03405032486134332 0.19963387570126506 7.745743084492289e-06 5.110936912054005 -0.25618596777932057 SGSSSPDS(ph)EITELKFPSINHD ddPTM_A459_Selumetinib_30min_R2 2 SGSSSPDSEITELKFPSINHD 21 1 B4E1E0;P17812-2;P17812 B4E1E0 CTPS1 CTP synthase;CTP synthase 1 1 S(0.019)GS(0.019)S(0.051)S(0.06)PDS(0.849)EIT(0.001)ELKFPSINHD;S(0.035)GS(0.126)S(0.126)S(0.191)PDS(0.511)EIT(0.011)ELKFPSINHD 65.02199999999999 0.0057205 4658900.0 10176.6 9790.4 18064.3 16270.9 18215.5 15281.2 9791.7 10881.3 12182.3 14789.9 True False 9611.025312157546 10541.29219890228 16902.062604922718 14054.775351131932 15927.106041363859 17386.046591077837 10247.033451885469 10912.962781503813 14619.100401901944 14362.877158224916 0.6691573844348995 0.7339262240271823 1.1767880779544044 0.9785487403603846 1.1089077672883378 1.210484946682267 0.7134387726777636 0.7598033918471895 1.0178392700051955 1.0 13.810057156992222 -5.107845310428979 6.762626907228462 0.9877387688653719 0.685025893876684 0.3789718093805322 0.15126349587030408 0.2576034302761997 13.757616160983943 0.041970923681943315 0.11414087243625157 7.801079244870084e-06 5.107845310428979 -0.30271287498868793 SGST(ph)SPLGFAR ddPTM_A459_Selumetinib_30min_R1 1 SGSTSPLGFAR 11 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 S(0.072)GS(0.041)T(0.443)S(0.443)PLGFAR 139.31 0.002758 26843000.0 5582.1 6258.5 6745.8 7193.4 6967.4 5726.3 5713.5 5743.9 3007.3 5317.5 True False 5712.15206912418 5525.751910502286 5829.757412027014 5937.20772684158 6337.199900194379 5668.698621064401 5282.5260950347565 5591.553113183318 5103.168455498311 6000.052921836222 0.9520169477731983 0.920950528684873 0.9716176653726761 0.9895258932190536 1.0561906674408095 0.9447747703081234 0.8804132503248192 0.9319172990681074 0.8505205740646312 1.0 12.550759510338903 -7.000747367861725 24.999706924206308 0.9104041856628717 0.9776982312867912 0.2694124244314091 0.04815961649676578 35.370732181269474 1183208.2787572497 0.017278364560792122 0.015061870339808894 9.98280601764314e-08 7.000747367861725 0.0672940456239195 SGST(ph)SPLGFAR ddPTM_A459_Selumetinib_30min_R2 2 SGSTSPLGFAR 11 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 SGS(0.001)T(0.633)S(0.366)PLGFAR;S(0.031)GS(0.018)T(0.475)S(0.475)PLGFAR 160.67 0.0014087 38816000.0 179367.0 149356.0 178927.0 198306.0 193070.0 132594.0 142586.0 149254.0 122495.0 155962.0 True False 169398.50020299156 160811.12494476745 167415.03162098798 171296.3807030688 168814.82053230033 150857.61993150873 149216.53152879895 149688.3044296701 146997.42279626834 151458.97182205942 1.1184448049865827 1.0617471055705787 1.1053490566255424 1.1309754624791408 1.1145910902566494 0.9960296053557185 0.9851944043572738 0.9883092604479741 0.9705428541332454 1.0 17.20856751456958 -6.784885229183142 6.888190709988817 0.9865515315649309 1.1051886255294774 0.9130108392448966 0.0182443119168599 0.04886283844613743 8.599319135267654 0.006790448386225789 0.006145505938210836 1.6410233884498787e-07 6.784885229183142 0.11863709396454647 SGSTS(ph)PLGFAR ddPTM_A459_Selumetinib_30min_R1 1 SGSTSPLGFAR 11 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 S(0.002)GS(0.001)T(0.321)S(0.676)PLGFAR 139.76 0.001142 34231000.0 6033.1 6903.2 7438.9 7736.4 7333.2 6699.4 6720.5 6685.6 3355.6 5164.2 True False 6173.659491630945 6094.970134789383 6428.738238952793 6385.3829702139665 6669.913354781611 6632.010118568513 6213.567274294411 6508.27617011062 5694.208116672811 5827.075373567771 1.0594782280722361 1.0459741369464366 1.1032529745735276 1.0958126608725087 1.1446416816636769 1.1381370058558038 1.0663269094612724 1.1169026918088014 0.9771982944484192 1.0 12.508556256814483 -8.26421963595214 24.999237219089945 0.9885991320679993 1.0968574755975342 0.6588950934969915 0.030999247217828117 163.3238577498821 1468516.421571199 0.028123330018376774 0.00849507032073744 5.442273508804367e-09 8.26421963595214 0.1082583435295349 SGSTS(ph)PLGFAR ddPTM_A459_Selumetinib_30min_R2 2 SGSTSPLGFAR 11 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 S(0.002)GS(0.009)T(0.205)S(0.784)PLGFAR;S(0.002)GS(0.033)T(0.217)S(0.749)PLGFAR 163.46 0.00063861 14764900.0 112982.0 98561.0 117426.0 138796.0 128197.0 88615.0 101337.0 118635.0 86673.0 115001.0 True False 106702.91274278093 106120.311776435 109870.93900376187 119891.74536354504 112091.74676427896 100820.91188312176 106049.371295456 118980.2082089186 104010.02184596093 111680.62232151805 0.9554290666073945 0.9502123964793513 0.9837959058596014 1.0735232565089754 1.0036812513595896 0.9027610142865053 0.9495771879758137 1.0653612572679414 0.9313166392154032 1.0 16.769019360295317 -6.426122243441562 0.0024772972543030632 1.8513043898243056 0.11221507905677197 0.0077709164195033376 0.052460280570283575 495870.50409354223 384.3015601828907 133718.11371792032 136062.42262311565 3.748674712252724e-07 6.426122243441562 -1.7390893107675336 SGSTS(ph)SLSYSTWTSSHSDK ddPTM_A459_Selumetinib_30min_R2 1 SGSTSSLSYSTWTSSHSDK 19 0 Q9ULD2;Q9ULD2-5;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 S(0.202)GS(0.202)T(0.05)S(0.273)S(0.273)LSYSTWTSSHSDK 127.07 0.00023548 9950200.0 23767.0 17116.0 35724.0 55982.0 56287.0 38673.0 27562.0 62298.0 58345.0 98351.0 True False 22446.12528683926 18428.74216338571 33425.556733350284 48357.15502566346 49215.7238478355 43999.8547114594 28843.687613066882 62479.27686601089 70015.63029550818 95511.35108341332 0.23501002794145684 0.19294818840214353 0.3499642330905633 0.5062974659779601 0.5152866469751195 0.46067670713853504 0.30199224789393575 0.6541555130075127 0.7330608299568617 1.0 16.543384580536532 -8.884524471911934 0.1517162079437972 1.4023006474607485 1.2377603329415114e-17 0.8206836701589316 0.09983753498650594 4.236033082915383 0.3438098870769109 1.7995442243179012 0.9952137712597623 1.3045944544198505e-09 8.884524471911934 -1.4023006474607485 down SGSYSGRS(ph)PSPYGR ddPTM_A459_Selumetinib_30min_R1 1 SGSYSGRSPSPYGR 14 1 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 S(0.001)GS(0.001)YS(0.004)GRS(0.935)PS(0.058)PYGR 86.777 0.012593 10904000.0 2068.5 2823.7 3683.8 4037.0 4083.2 3056.5 3268.9 2185.4 1169.4 1902.4 True False 2116.692025399648 2493.0998912974824 3183.5601936649655 3332.013733875419 3713.8752809475122 3025.7543850799552 3022.3242411935116 2127.4360928203528 1984.3863904032607 2146.5915709452242 0.9860711530082035 1.1614225663802815 1.4830768166405897 1.5522346118261374 1.7301266487840323 1.4095622222850726 1.407964273270052 0.9910763284529079 0.9244359370746348 1.0 11.067832002349162 -7.772692528700309 6.235422944440384 0.9637908881542594 1.4057281736910718 0.4960420394488737 0.1927887636655942 0.14228165225636108 21.12509647973397 0.11459818573508997 0.057990139887380346 1.6877474920070486e-08 7.772692528700309 0.44193728553681244 SGT(ph)FDLLEMDR ddPTM_A459_Selumetinib_30min_R1 3 SGTFDLLEMDR 11 0 H0YA31;H0YA26;E9PHT6;Q9NVE7 H0YA31 PANK4 Pantothenate kinase 4 1 S(0.093)GT(0.907)FDLLEMDR;S(0.138)GT(0.862)FDLLEMDR;S(0.361)GT(0.639)FDLLEMDR 193.15 4.7387e-05 16461500.0 4624.96 5764.8 3259.56 3792.3999999999996 3659.37 3504.29 4333.42 4410.049999999999 3045.05 5999.5599999999995 True False 4732.7125693944145 5089.854536017187 2816.9296554814523 3130.1285321647615 3328.380629614246 3469.040024240744 4006.5466405435413 4293.081148138739 5167.227448347402 6769.661966663228 0.6991061876797332 0.7518624358323729 0.41611082936684934 0.46237589817318525 0.4916612743745029 0.5124391795814639 0.5918385083736126 0.6341647735558652 0.7632917971079038 1.0 12.724868081358343 -8.528588443701507 1.2612917445015057 0.9984346540919675 0.552213025957632 0.6660624937858348 0.09713064858993209 0.3217817065211766 1.1230439459345576 0.10254739341168696 0.03160130699890095 2.9608169361448703e-09 8.528588443701507 -0.4462216281343355 SGT(ph)LKSPPKGFDTTAINK ddPTM_A459_Selumetinib_30min_R2 1 SGTLKSPPKGFDTTAINK 18 2 B1ALK7;A0A2R8YG42;Q14155-1;Q14155-5;Q14155-6;Q14155-2;Q14155-3;Q14155;E7EUY6;E7EU80 B1ALK7 ARHGEF7 Rho guanine nucleotide exchange factor 7 1 S(0.097)GT(0.543)LKS(0.36)PPKGFDTTAINK 80.738 0.035784 6786500.0 40281.0 35642.0 33415.0 34102.0 27376.0 24185.0 25943.0 24482.0 19173.0 31564.0 True False 38042.34327761907 38375.62679290682 31265.115279501188 29457.248770768747 23936.782135454803 27516.26422042883 27149.40090507927 24553.23856678671 23008.135738379944 30652.665306879084 1.2410778278742889 1.2519507327897696 1.01998031709447 0.961001220476509 0.7809037777241152 0.8976793353840463 0.8857109368230498 0.8010147998867968 0.7506079979680086 1.0 14.903724903965907 -5.510034484404377 1.4867457778434838 0.8472511083297622 1.2753472213137569 0.8201818093908793 0.07096063784714719 0.17233163070408253 0.7095387362230271 0.02165156139933897 0.07183720186247669 3.0900500626758245e-06 5.510034484404377 0.42809611298399464 SGT(ph)NSPPPPFSDWGR ddPTM_A459_Selumetinib_30min_R1 1 SGTNSPPPPFSDWGR 15 0 D6RAU6;D6REP2;D6RAJ6;Q9UKT5-2;Q9UKT5 D6RAU6 FBXO4 F-box only protein 4 1 S(0.039)GT(0.568)NS(0.393)PPPPFSDWGR 123.76 0.0032854 24457000.0 1894.4 2215.8 2455.4 2535.3 2110.1 2488.6 2421.3 2096.6 1004.7 1954.4 True False 1938.5358341392757 1956.3731059025276 2121.970166546759 2092.5574484751924 1919.2418275684136 2463.566943468012 2238.6593916001857 2040.9913572834032 1704.9025196153204 2205.2662774681194 0.8790484187537304 0.8871369076339627 0.9622285472859119 0.9488910567651138 0.8702993589381449 1.1171290145952122 1.0151424408350385 0.9255078981331355 0.7731050608422354 1.0 11.106737150870764 -5.251150777069071 14.686253305002989 0.9540673233617939 0.8830867837372278 0.09238584003096117 0.08551915635977411 7.178296368836002 10218.641973793188 0.022866375553176742 0.05729663451267944 5.608532268697356e-06 5.251150777069071 -0.07098053962456607 SGT(ph)NSPPPPFSDWGR ddPTM_A459_Selumetinib_30min_R2 1 SGTNSPPPPFSDWGR 15 0 D6RAU6;D6REP2;D6RAJ6;Q9UKT5-2;Q9UKT5 D6RAU6 FBXO4 F-box only protein 4 1 S(0.011)GT(0.967)NS(0.022)PPPPFSDWGR 182.37 4.8269e-05 13865000.0 43376.0 31448.0 43293.0 36981.0 47599.0 35233.0 32452.0 30804.0 26806.0 34570.0 True False 40965.33556788573 33859.96047874232 40507.575513854375 31944.124004216705 41619.18807954098 40086.02593667025 33961.082302418065 30893.63454012326 32167.949022219418 33571.874276353126 1.2202278380608707 1.0085811772085693 1.2065926132216729 0.9515144653903653 1.239704037282664 1.1940359840113386 1.0115932766476217 0.9202237052902249 0.9581815050724592 1.0 15.034965462718894 -7.453119010571718 4.950657471956953 0.9557417774178543 1.129733025087023 0.4527608136905441 0.0895250859435885 0.19739922561261322 9.182118714342124 0.038193323601744086 0.02474874902516174 3.522743233882836e-08 7.453119010571718 0.17399124766916874 SGT(ph)PPRQGSIT(ph)SPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R2 1 SGTPPRQGSITSPQANEQSVTPQR 24 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.186)GT(0.802)PPRQGS(0.014)IT(0.859)S(0.138)PQANEQS(0.001)VT(0.001)PQR 87.025 0.0024368000000000003 0.0 8936.4 10720.0 11859.0 10879.0 11412.0 7859.4 6048.4 6732.3 3060.6 9277.3 True False 8439.750663243587 11542.18952976717 11096.004851102934 9397.261432678233 9978.322535425563 8941.961009470268 6329.662584677231 6751.889878407735 3672.8055203090644 9009.440243679801 0.9367674833255201 1.2811217142889777 1.2315975855311185 1.0430460914894788 1.1075407867237304 0.9925101635191076 0.7025589174774253 0.7494239037929402 0.4076618991824235 1.0 13.137221758874762 -7.124801805028718 1.9923615651199607 0.680119978982207 1.1355583447216953 0.5807220693896036 0.16152368934629519 0.22088632490661322 1.7266208814282202 0.07354548173006059 0.0520039303627803 7.502365097438304e-08 7.124801805028718 0.45543836573948826 SGT(ph)PPRQGSITSPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R1 1 SGTPPRQGSITSPQANEQSVTPQR 24 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.147)GT(0.55)PPRQGS(0.268)IT(0.027)S(0.009)PQANEQSVTPQR 66.52 0.0035102 14680000.0 432.45 446.71 793.12 699.24 671.59 412.51 446.07 615.08 396.06 391.71 True False 442.52524359878043 394.4089855301551 685.4186602963127 577.1308603604281 610.8448030788445 408.36052392911273 412.42258076698243 598.7660803385846 672.0848929221102 441.98979407850806 1.0012114522268296 0.8923486261768718 1.5507567583666102 1.3057560787431117 1.3820337285216675 0.9239139215431251 0.9331043075934152 1.354705670493897 1.5205891672755043 1.0 8.787869246716504 -5.2173609520962785 24.994595423771457 1.2432891967474713 0.946779814822743 0.2338028033540921 0.21687044706413186 717.102687203196 406629.40466212656 0.0584476392257045 0.15463621995006263 6.062322666190663e-06 5.2173609520962785 -0.2965093819247283 SGT(ph)PPRQGSITSPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R2 1 SGTPPRQGSITSPQANEQSVTPQR 24 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.117)GT(0.611)PPRQGS(0.25)IT(0.017)S(0.005)PQANEQSVTPQR 74.579 0.00062418 6163500.0 14090.0 16070.0 13555.0 13003.0 13356.0 8401.1 7457.7 7420.7 3270.3 11713.0 True False 13306.934206738983 17302.517326805813 12682.886057568105 11231.968968573858 11678.099875845064 9558.27526740727 7804.497827152198 7442.293008436982 3924.451379816613 11374.81525597119 1.1698593697821624 1.521125129282683 1.114997103000002 0.9874418806650643 1.0266628172017709 0.8403015831302991 0.6861208425389801 0.6542781435092022 0.3450123181347037 1.0 13.473555493523763 -6.323290090948503 0.7646026134391904 0.62745512155107 1.352166639037311 0.6432800025042638 0.18353248335208103 0.4136711058753877 0.5273710209353755 0.10528679503581682 0.17034587515899643 4.750178274725099e-07 6.323290090948503 0.7247115174862411 SGT(ph)PTQDEMMDKPTSSSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R1 1 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.156)GT(0.623)PT(0.215)QDEMMDKPT(0.002)S(0.001)S(0.001)S(0.001)VDTMSLLSK 88.927 7.807e-05 87928000.0 2748.7 2954.3 3523.7 3697.9 2398.2 2947.7 2849.7 2649.4 1758.2 2423.6 True False 2812.7393619608456 2608.4091825831906 3045.2008942986163 3052.1311831800635 2181.283233436598 2918.048814297459 2634.744834693369 2579.129305535939 2983.5369861527406 2734.6926678631444 1.0285394753914654 0.9538216901796756 1.113544103176354 1.1160783144107238 0.7976337740141843 1.0670481727577772 0.9634518955843496 0.9431148647322184 1.0909953506709915 1.0 11.417162992830448 SGT(ph)PTQDEMMDKPTSSSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R2 3 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.043)GT(0.435)PT(0.329)QDEMMDKPT(0.067)S(0.028)S(0.023)S(0.043)VDT(0.022)MS(0.009)LLS(0.001)K;S(0.089)GT(0.429)PT(0.477)QDEMMDKPT(0.001)S(0.001)S(0.001)SVDT(0.001)MSLLSK;S(0.256)GT(0.382)PT(0.276)QDEMMDKPT(0.026)S(0.035)S(0.014)S(0.007)VDT(0.004)MSLLSK 70.062 0.0012137 26543900.0 95916.0 84944.0 76428.0 81962.0 80139.0 62546.7 70084.2 73326.1 52963.8 72304.4 True False 90585.37270217013 91458.93166199101 71510.7056885146 70798.63420766358 70071.22236825002 71161.94018258815 73343.25416920769 73539.46681121076 63558.03993221762 70216.7841026077 1.2900814792343358 1.3025223645722965 1.0184275255901225 1.0082864818218622 0.9979269666616323 1.0134605435446788 1.044525964932135 1.0473203487039173 0.9051687676174452 1.0 16.099528302491798 -5.268974869525964 7.107297706939885 1.007391389655846 1.2973500858707498 0.9082053635013615 0.03711579737992771 0.03219117270781852 11.317943345892802 0.00952198099687773 0.02186077778117864 5.3830093042798095e-06 5.268974869525964 0.2899586962149039 SGT(ph)TPKPVINSTPGR ddPTM_A459_Selumetinib_30min_R1 1 SGTTPKPVINSTPGR 15 1 Q99459 Q99459 CDC5L Cell division cycle 5-like protein 1 S(0.003)GT(0.852)T(0.136)PKPVINS(0.008)T(0.001)PGR 108.66 0.040821 3114600.0 1885.7 2296.8 2653.8 2821.3 2336.4 1734.2 1983.9 1658.2 1250.1 1469.0 True False 1929.633141066529 2027.8895882466488 2293.42853627995 2328.6129173600993 2125.073032524924 1716.7555225276153 1834.2528257529457 1614.2191494072983 2121.3283963084623 1657.5604592717286 1.164140427139737 1.223418172714876 1.3836168228141728 1.4048434277825417 1.282048579669066 1.0357121593512764 1.1065978411181752 0.9738523505299632 1.279789454702905 1.0 10.69484577804715 -6.730699652927945 8.596739391964368 1.0792899054367906 1.2996987556316293 0.5224466197649251 0.10140703036756307 0.2035097714365385 50.843698575341044 0.034220974837039446 0.033813513979198774 1.8590897100070262e-07 6.730699652927945 0.2204088501948387 SGTAETEPVEQDS(ph)SQPSLPLVR ddPTM_A459_Selumetinib_30min_R1 1 SGTAETEPVEQDSSQPSLPLVR 22 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SGTAETEPVEQDS(0.686)S(0.314)QPSLPLVR 234.03 3.9183e-31 4710600.0 2001.3 2353.8 2408.9 2666.7 2472.8 1968.9 2536.7 2150.8 1078.4 1941.7 True False 2047.9263961480842 2078.2160017480664 2081.784611140543 2201.010905158678 2249.1356766082995 1949.0946536181655 2345.354676691114 2093.753797216993 1829.9660367802958 2190.9361087596417 0.9347266622519085 0.9485516229519857 0.9501804287296662 1.0045983980814208 1.0265637905258709 0.8896172945552527 1.0704806348820886 0.9556434753372764 0.8352439075990662 1.0 11.097331698282964 -5.543085696819071 24.552989283772124 0.9709048688412318 0.9435708335523689 0.030329863543222646 0.06351577222895927 784.5538825061639 953289.11802651 0.01727481952815002 0.029925402665750087 2.863612853985501e-06 5.543085696819071 -0.027334035288862912 SGTAETEPVEQDSS(ph)QPSLPLVR ddPTM_A459_Selumetinib_30min_R1 1 SGTAETEPVEQDSSQPSLPLVR 22 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SGTAETEPVEQDS(0.081)S(0.915)QPS(0.004)LPLVR 169.33 5.182e-12 6198000.0 2343.4 2912.0 2965.7 3107.3 3185.1 2260.9 3024.6 2703.7 1826.1 2481.3 True False 2397.996660537361 2571.061686247928 2562.974229424014 2564.6683862450077 2897.0082673750767 2238.157398732953 2796.4519868805714 2631.989093144683 3098.7583269329543 2799.7990249087416 0.8564888548082564 0.9183022293293822 0.9154136445588459 0.9160187439984562 1.0347200786918995 0.7993993064576858 0.9988045434695874 0.9400635794672697 1.1067788435400134 1.0 11.45110755605601 -7.942209268996539 1.9840862528662095 1.0468440011492302 0.9163003028116662 0.36565257692087294 0.06734612270071953 0.36439584091587873 2.666697659126803 0.051871186100412074 0.018166331218777133 1.1423277604708317e-08 7.942209268996539 -0.13054369833756396 SGTLS(ph)PEIFEK ddPTM_A459_Selumetinib_30min_R1 1 SGTLSPEIFEK 11 0 O60673-2;O60673 O60673-2 REV3L DNA polymerase zeta catalytic subunit 1 S(0.29)GT(0.081)LS(0.629)PEIFEK 116.01 0.006011600000000001 4396900.0 2423.2 2720.2 3343.2 3418.2 2619.8 2296.2 2599.1 2916.3 1517.8 2121.4 True False 2479.655845273593 2401.7177194133296 2889.2118028830837 2821.275537560804 2382.839552563256 2273.102312782788 2403.0477944525846 2838.950250522556 2575.595744274046 2393.7023541858694 1.0359081783653747 1.003348522097346 1.2070054565600925 1.1786242064002808 0.9954619246609263 0.9496177788386313 1.0039041780822804 1.186008045469012 1.075988307305668 1.0 11.225028055641669 SGTNS(ph)PPPPFSDWGR ddPTM_A459_Selumetinib_30min_R1 1 SGTNSPPPPFSDWGR 15 0 D6RAU6;D6REP2;D6RAJ6;Q9UKT5-2;Q9UKT5 D6RAU6 FBXO4 F-box only protein 4 1 S(0.097)GT(0.212)NS(0.691)PPPPFSDWGR 133.87 0.00050037 25253000.0 4483.9 5013.2 5184.9 5965.1 4891.1 4970.6 5056.4 4821.0 2341.5 4108.7 True False 4588.366145849397 4426.252213426546 4480.819058617048 4923.407263794966 4448.700868593841 4920.600276943702 4674.991677069007 4693.1314191850115 3973.3544836063234 4636.091667127126 0.9897056562500406 0.9547378549072969 0.9665078648873444 1.0619736660310433 0.9595800057488063 1.0613682019779558 1.008390690420922 1.012303413338941 0.8570483003560875 1.0 12.178693376977627 -8.219903381542338 24.99818808210131 0.928523977049859 1.0018753557015216 0.27266180311173727 0.04788507136850808 537.9163930241663 323742.6390627669 0.031040745315469815 0.01173212348183312 6.02693653755962e-09 8.219903381542338 0.07335137865166264 SGTNS(ph)PPPPFSDWGR ddPTM_A459_Selumetinib_30min_R2 1 SGTNSPPPPFSDWGR 15 0 D6RAU6;D6REP2;D6RAJ6;Q9UKT5-2;Q9UKT5 D6RAU6 FBXO4 F-box only protein 4 1 S(0.001)GT(0.042)NS(0.957)PPPPFSDWGR 135.57 0.00063777 0.0 28224.0 24488.0 31230.0 28060.0 27914.0 19696.0 23114.0 24863.0 15095.0 24943.0 True False 26655.423069623925 26366.15085866963 29220.695800653055 24238.179593800105 24407.19376567378 22408.94521751361 24188.8467995221 24935.347213708785 18114.42178953973 24222.83078030305 1.1004255989477065 1.0884834682538191 1.206328693193615 1.0006336506924507 1.0076111246882278 0.9251166975800197 0.9985970268673724 1.0294150770348907 0.7478243130967825 1.0 14.564079853750227 -5.923308886306729 5.395351096146046 0.9579366490346181 1.1268408145554343 0.498881611872651 0.08056389256693036 0.175238647676973 8.946720979261851 0.022529375379805917 0.03380335051670942 1.1931391978631654e-06 5.923308886306729 0.16890416552081622 SGTPPRQGS(ph)ITSPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R1 1 SGTPPRQGSITSPQANEQSVTPQR 24 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SGT(0.001)PPRQGS(0.905)IT(0.069)S(0.024)PQANEQSVTPQR 75.054 0.000239 14947000.0 359.06 447.52 631.31 689.67 640.89 631.08 615.15 600.4 195.61 279.7 True False 367.42539939086186 395.1241503535963 545.5815695376049 569.2320812092792 582.9216126583199 624.7319081747941 568.7487402398936 584.4754416259448 331.9358832108622 315.60221950871517 1.164204104656861 1.2519688580412065 1.7287000401546255 1.8036377630530578 1.8470136666520587 1.9794914913693833 1.8021062751879282 1.8519370444725431 1.0517539570145387 1.0 8.301963541079699 -8.27220134774063 23.46334851512012 1.0258764778280927 1.6900031903564854 0.5188161920232629 0.2512635542846298 309.0690705648329 673818.8091306485 0.2614013950677663 0.07063996237025824 5.34316581946814e-09 8.27220134774063 0.6641267125283927 SGTPPRQGS(ph)ITSPQANEQSVTPQR ddPTM_A459_Selumetinib_30min_R2 1 SGTPPRQGSITSPQANEQSVTPQR 24 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.246)GT(0.246)PPRQGS(0.465)IT(0.03)S(0.012)PQANEQSVTPQR 62.19300000000001 0.0031623000000000003 6225500.0 4016.9 7181.4 7248.1 5024.3 5045.2 3897.1 3719.7 4297.0 780.55 5902.7 True False 3793.6567789247542 7732.190288159503 6781.765137134588 4339.981672599066 4411.376871339734 4433.890150648473 3892.6734204457216 4309.503558593354 936.6818103892177 5732.273713943578 0.6618066352443712 1.3488871386848102 1.1830846668466224 0.7571134752414553 0.7695684280757907 0.7734958887017507 0.679080172144766 0.7517965424628311 0.1634049344347895 1.0 12.484891784059956 -5.853604004222761 5.1136551713394836 0.6882941736817204 1.0916891132728752 0.30094045607740394 0.2552517771065355 0.23330932288340844 10.005832073349964 0.07086446370207655 0.10792500334493225 1.4008640678391869e-06 5.853604004222761 0.4033949395911548 SGTPT(ph)QDEMMDKPTSSSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R2 2 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.032)GT(0.3)PT(0.553)QDEMMDKPT(0.026)S(0.032)S(0.04)S(0.013)VDT(0.004)MSLLSK;S(0.097)GT(0.386)PT(0.504)QDEMMDKPT(0.003)S(0.004)S(0.005)S(0.001)VDTMSLLSK 83.56700000000002 0.00014961 17858700.0 64775.0 62732.0 57155.0 62607.0 54726.0 42617.0 53271.0 51948.0 44117.0 51509.0 True False 61175.064814869926 67543.34268482772 53477.709525658785 54079.81859690101 47850.830623352536 48487.10491139205 55748.20705448393 52099.16007954563 52941.63273197247 50021.80133354564 1.2229680496100943 1.35027809643336 1.0690880396143498 1.08112497261537 0.9565995095674972 0.9693194490954009 1.1144781988708201 1.041529067139109 1.0583711765787358 1.0 15.61026939085043 -5.351375201545786 5.0065115862583935 1.0344325776000456 1.2855556181172219 0.7744046707524264 0.05420024018578401 0.09280051089543945 3.812426852804423 0.014711434242069384 0.031984937446308315 4.452713973079892e-06 5.351375201545786 0.25112304051717627 SGTPTQDEMMDKPT(ph)SSSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R1 1 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.001)GT(0.002)PT(0.021)QDEMMDKPT(0.583)S(0.188)S(0.188)S(0.015)VDT(0.003)MS(0.001)LLSK 84.947 0.00013037 94360000.0 2083.8 2114.5 2563.7 2891.3 1876.8 2002.9 2251.6 1948.8 1308.8 1972.0 True False 2132.348485631029 1866.933356995619 2215.5636213960765 2386.388731422838 1707.0437713759518 1982.752644487697 2081.7599992264413 1897.1114934054663 2220.9380090300897 2225.125408906636 0.9583048564794399 0.8390238813159648 0.9957028096159048 1.072473812878458 0.7671674434811946 0.8910745599107448 0.9355697395273372 0.8525863242636977 0.9981181285963545 1.0 11.11967093386878 -8.303150198653933 20.001412354425597 0.9990608051323756 0.9145574672901479 0.14980853979939968 0.08105570494201372 114.07481118113542 54693.86066415457 0.07926380743100267 0.020470879635276436 4.975649747698842e-09 8.303150198653933 -0.08450333784222774 SGTPTQDEMMDKPTS(ph)SSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R1 1 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.002)GT(0.007)PT(0.069)QDEMMDKPT(0.295)S(0.37)S(0.125)S(0.058)VDT(0.067)MS(0.006)LLS(0.001)K 53.99800000000001 0.023058 20918000.0 1473.3 1933.6 2030.8 2337.4 1833.1 1704.3 1510.8 2284.6 1411.2 1614.5 True False 1507.6250234572394 1707.2132130937473 1755.0285143859091 1929.216968432104 1667.2964286600911 1687.1562893805883 1396.8391396479424 2224.0049865733417 2394.7033300299995 1821.736801561745 0.8275756531705223 0.9371349426712912 0.9633820389868349 1.0589987350413177 0.9152235532766013 0.9261251614032372 0.766762321785702 1.2208157537723006 1.3145166348821957 1.0 10.831098823104849 -7.779970274614426 24.996613261991556 1.2007498331295179 0.9225566018507232 0.5746657570666378 0.10368294759099601 170.59054762065153 230108.9745008636 0.055980884648422 0.02696862148231272 1.659700502132121e-08 7.779970274614426 -0.2781932312787947 SGTPTQDEMMDKPTS(ph)SSVDTMSLLSK ddPTM_A459_Selumetinib_30min_R2 1 SGTPTQDEMMDKPTSSSVDTMSLLSK 26 1 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2;Q5VT52-5 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.098)GT(0.152)PT(0.098)QDEMMDKPT(0.16)S(0.206)S(0.104)S(0.13)VDT(0.04)MS(0.012)LLSK 59.912 0.003385 10033000.0 47918.0 42210.0 42453.0 44055.0 33840.0 30249.0 39034.0 31728.0 26515.0 39969.0 True False 45254.909390952314 45447.371273458215 39721.62019933153 38054.63300088609 29588.71666656159 34415.5251769176 40849.15834440365 31820.32322714686 31818.740891000092 38814.99111806648 1.1659131713645652 1.170871613372718 1.0233577042052462 0.9804107100046074 0.7623012607824479 0.8866554953531565 1.0524067420278338 0.8197946801110063 0.8197539140023151 1.0 15.244326336978558 -5.567207431540839 1.8087070028740575 0.8900746294577322 1.1754560951459918 0.623766614388834 0.08333013121762335 0.24031215962949445 1.544349325146094 0.025846840412548075 0.06770075708675202 2.7088974754728403e-06 5.567207431540839 0.2853814656882596 SGTSSPQS(ph)PVFR ddPTM_A459_Selumetinib_30min_R1 4 SGTSSPQSPVFR 12 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 SGTS(0.001)S(0.013)PQS(0.986)PVFR;SGT(0.001)SS(0.008)PQS(0.99)PVFR;SGTS(0.002)S(0.028)PQS(0.969)PVFR;SGTSS(0.002)PQS(0.998)PVFR 151.07 0.00053239 930825000.0 14456.6 15943.2 17285.4 17106.3 16352.3 13937.300000000001 14782.5 13340.3 7895.1 10584.6 True False 14793.410652353181 14076.562732207414 14938.13762190575 14119.005830020591 14873.237352233047 13797.103416055901 13667.444123540965 12986.47190859859 13397.40806471079 11943.236512734873 1.2386433640980998 1.1786221194897892 1.2507612660921068 1.1821758545069196 1.245327205600757 1.1552231592620879 1.1443668647914322 1.0873494713724654 1.1217569082237766 1.0 13.543906226884609 -8.03489386107192 0.49745078651972036 1.0018414268152294 1.2279695532641106 0.831667627556253 0.03046825924539647 0.32401552064254446 0.20037022820783768 0.03110311996237933 0.018818902168997283 9.227969255505014e-09 8.03489386107192 0.22612812644888125 SGTSSPQS(ph)PVFR ddPTM_A459_Selumetinib_30min_R2 7 SGTSSPQSPVFR 12 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 SGTSSPQS(1)PVFR;SGTSS(0.002)PQS(0.998)PVFR;SGT(0.001)SS(0.002)PQS(0.996)PVFR;SGTSSPQS(1)PVFR;S(0.001)GT(0.003)S(0.003)S(0.018)PQS(0.975)PVFR;S(0.002)GT(0.008)S(0.001)S(0.018)PQS(0.972)PVFR;SGT(0.001)S(0.04)S(0.028)PQS(0.931)PVFR 162.88 0.00049558 993104700.0 307940.0 310319.0 349963.0 355927.0 373848.0 277983.0 270894.0 295756.0 252575.0 352823.0 True False 290825.9275814903 334119.46946714696 327446.761590905 307449.12859167863 326881.8719964749 316272.63497157214 283491.1077662778 296616.60099495854 303097.0575351446 342636.0832457553 0.8487895519541524 0.9751438502975771 0.9556692292564068 0.897305169027283 0.9540205716221059 0.9230569996468411 0.8273825251584613 0.8656899127060435 0.8846034389137838 1.0 18.38631756508385 -7.0321227134918445 24.198000393636573 0.8820826347092264 0.9298990583404183 0.05619698395054573 0.053014938242575436 826.8800669407035 622885.0181935262 0.019244845223671113 0.014924278170771512 9.287039367373075e-08 7.0321227134918445 0.04781642363119187 SGVGT(ph)GPPSPIALPPLR ddPTM_A459_Selumetinib_30min_R1 1 SGVGTGPPSPIALPPLR 17 0 Q92630 Q92630 DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 1 S(0.003)GVGT(0.63)GPPS(0.367)PIALPPLR 87.824 0.02436 16436000.0 1183.4 1336.8 1552.6 1330.6 1281.9 1274.7 1190.2 1140.0 893.09 902.21 True False 1210.9709175044443 1180.2868345385407 1341.7654478213321 1098.2356884554454 1165.9523713378262 1261.8776753349969 1100.4222557644828 1109.763496758124 1515.5085012871973 1018.0174417696019 1.189538477257752 1.1593974583449855 1.3180181328612257 1.0787984993129405 1.1453166944871511 1.2395442588306709 1.0809463675314226 1.0901222820200815 1.4886861846421957 1.0 9.991546564090378 -5.773273199771127 24.998640066908514 1.1635905466131358 1.216026000208994 0.0435375496641448 0.13125550622344093 925.6332970681781 1955375.2696904815 0.03595085939035619 0.05380519984069658 1.6854924063293425e-06 5.773273199771127 0.05243545359585822 SGVGTGPPS(ph)PIALPPLR ddPTM_A459_Selumetinib_30min_R1 1 SGVGTGPPSPIALPPLR 17 0 Q92630 Q92630 DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 1 SGVGT(0.016)GPPS(0.984)PIALPPLR 101.3 0.004039 19917000.0 1894.4 2050.1 2536.7 2446.7 1862.3 1788.9 1708.2 2011.0 1184.2 1977.0 True False 1938.5358341392757 1810.0733389343666 2192.2300730956945 2019.4297752472112 1693.8552938157695 1770.9052901912435 1579.3490987202895 1957.6617473513909 2009.5009094540285 2230.7672076107588 0.8689996103248826 0.8114129223160976 0.9827247171360659 0.9052624443991633 0.7593151307033765 0.7938548155761865 0.7079847208314649 0.8775733033336658 0.9008115694897114 1.0 11.123324253220076 -8.538916165656458 2.130339386832915 0.9980010429861911 0.835649368934588 0.32082975734391783 0.07312908036515477 0.43634711129334136 4.58154755290021 0.07664766713211085 0.021231014843449254 2.891237940669002e-09 8.538916165656458 -0.1623516740516031 SGVGTGPPS(ph)PIALPPLR ddPTM_A459_Selumetinib_30min_R2 1 SGVGTGPPSPIALPPLR 17 0 Q92630 Q92630 DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 1 SGVGTGPPS(1)PIALPPLR 89.23200000000001 0.0096441 2280700.0 8626.4 7074.8 5975.6 9067.8 7480.4 7165.5 7046.7 7166.7 5880.8 7625.6 True False 8146.97922221527 7617.4144109325325 5591.136401741351 7832.749997172501 6540.645276375518 8152.482583067312 7374.385512771149 7187.553910488943 7057.124323280904 7405.429114311785 1.1001360078473184 1.0286256600864714 0.7550050531083851 1.0577037300964602 0.8832229942941483 1.1008791600356778 0.9958079942348457 0.9705789900274955 0.9529662919387419 1.0 12.854367620872042 -6.741675367399106 24.999785910211383 1.0016928525756594 0.9619675409683368 0.0380099154111323 0.09744291559899337 1036.256146862695 1310773.3237487562 0.032433620252389515 0.032389779425774645 1.8126945649774961e-07 6.741675367399106 -0.03972531160732262 SGVS(ph)LAALK ddPTM_A459_Selumetinib_30min_R2 2 SGVSLAALK 9 0 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 S(0.008)GVS(0.992)LAALK;S(0.061)GVS(0.939)LAALK 106.29 0.013253 6514200.0 40934.0 44013.0 42282.0 33781.0 39469.0 27491.0 28657.0 26740.0 29858.0 35285.0 True False 38659.05215178518 47388.65557589946 39561.62215316081 29179.969524524608 34510.55136266312 31277.63571154888 29989.607282768244 26817.808972954692 35830.434302224414 34266.23036856002 1.1281968204841017 1.3829550279151668 1.1545367473353423 0.8515663733848541 1.0071300808835766 0.9127830921327944 0.8751942352633085 0.7826308492211793 1.0456485559351048 1.0 15.064499869109644 -5.6197920318779895 4.547537858894911 0.9175878453748252 1.2590207142269838 0.6807832807257808 0.09447251218130913 0.10512402854884755 3.7775898461822286 0.024889951761235915 0.04469423813897528 2.399981909543533e-06 5.6197920318779895 0.3414328688521586 SGVSS(ph)DNEDDDDEEDGNYLHPSLFASK ddPTM_A459_Selumetinib_30min_R1 2 SGVSSDNEDDDDEEDGNYLHPSLFASK 27 0 Q12872;Q12872-2 Q12872 SFSWAP Splicing factor, suppressor of white-apricot homolog 1 S(0.001)GVS(0.142)S(0.857)DNEDDDDEEDGNYLHPSLFASK;S(0.007)GVS(0.178)S(0.815)DNEDDDDEEDGNYLHPSLFASK 230.7 4.919699999999998e-49 28696000.0 3735.8 4009.5 3027.8999999999996 4617.5 7169.4 3688.6000000000004 6075.6 3515.1 1079.47 1879.9099999999999 True False 3822.836871398598 3540.0658760340207 2616.727811064157 3811.1403062099957 6520.929035860375 3651.496032980837 5617.312600506377 3421.8681293460327 1831.7817486305871 2121.2147603740736 1.8021922828428958 1.66888612231311 1.233598718973038 1.79667819468591 3.074148434979972 1.721417416658415 2.648158359748435 1.6131643967735687 0.8635531785134074 1.0 11.050674977214532 -8.112241674122656 4.155067858168182 0.9494131705320327 1.9829721959951234 0.4152471162442335 0.49589674877516987 0.2451463428055735 6.946773690211149 0.3897349947760864 0.13632368025523595 7.722507271014595e-09 8.112241674122656 1.0335590254630906 SGVSS(ph)DNEDDDDEEDGNYLHPSLFASK ddPTM_A459_Selumetinib_30min_R2 2 SGVSSDNEDDDDEEDGNYLHPSLFASK 27 0 Q12872;Q12872-2 Q12872 SFSWAP Splicing factor, suppressor of white-apricot homolog 1 S(0.015)GVS(0.206)S(0.778)DNEDDDDEEDGNYLHPSLFASK;S(0.013)GVS(0.197)S(0.79)DNEDDDDEEDGNYLHPSLFASK 134.05 3.3972e-12 4871000.0 18758.9 18425.5 36722.0 59334.0 68193.0 35696.0 24352.7 34430.1 43072.0 54817.0 True False 17716.355435826532 19838.676602679563 34359.346499890526 51252.606843140915 59625.985686845044 40612.79998397471 25485.1488039596 34530.28589079009 51687.60353223288 53234.29077832948 0.3327996893881504 0.3726672472314679 0.6454363531011381 0.9627742963000971 1.1200672501702134 0.7629067540899277 0.47873557497142516 0.6486474298037725 0.9709456588322537 1.0 15.70006823428057 -5.393432275151388 3.084508214133194 0.826115572452059 0.345150622249871 0.5484527489116284 0.17787984696761464 0.22174013905550036 3.9494745021856192 0.054318084390887554 0.1319632848717826 4.041733972990102e-06 5.393432275151388 -0.48096495020218805 SGVTNMSS(ph)PHK ddPTM_A459_Selumetinib_30min_R1 2 SGVTNMSSPHK 11 0 Q9NVG8 Q9NVG8 TBC1D13 TBC1 domain family member 13 1 SGVTNMS(0.01)S(0.99)PHK;SGVTNMS(0.115)S(0.884)PHK 128.08 0.0034414000000000003 4549900.0 4875.5 6218.700000000001 5321.4 5069.1 6587.5 4909.9 5741.9 5316.6 2565.7 4707.6 True False 4989.089663928441 5490.611713004802 4598.783108357876 4183.876843791896 5991.661788117586 4860.510863832511 5308.78386016979 5175.586497249331 4353.805508686203 5311.866315907137 0.93923479380268 1.0336502062490518 0.8657565599093049 0.7876472401541214 1.1279767659390647 0.9150288382215159 0.9994197038189543 0.9743442679930222 0.8196376282377656 1.0 12.375003123401758 -3.721475647004449 11.886473665851655 0.9469975456100389 0.9002492150715526 0.0 0.09790953609406348 0.0 0.0 0.02198132693528147 0.0 0.00018989973250955856 3.721475647004449 -0.04674833053848626 SGVTNMSS(ph)PHK ddPTM_A459_Selumetinib_30min_R2 2 SGVTNMSSPHK 11 0 Q9NVG8 Q9NVG8 TBC1D13 TBC1 domain family member 13 1 SGVTNMS(0.197)S(0.803)PHK;SGVTNMS(0.067)S(0.933)PHK 111.31 0.0055027 44318300.0 129692.0 118585.0 145986.0 145413.0 159040.0 118876.0 113731.0 122031.0 107463.0 133846.0 True False 122484.23783821087 127680.08818912657 136593.41969753886 125607.49854858371 139059.97336436046 135250.0899511143 119019.71685370116 122386.09000668045 128958.60276709536 129981.51820632782 0.9423204123818892 0.9822941749799534 1.050868012487095 0.966348910844379 1.0698442000317447 1.0405332374747565 0.9156664616332123 0.9415653217129633 0.9921303008816321 1.0 16.9879469785551 -8.5525391496652 20.82230862624197 1.0000000083963434 0.9902366632929962 0.004205932090605602 0.048376187535743215 14234.21250251211 9992757.390009716 0.04978565521912093 0.012854601095609009 2.8019530270059576e-09 8.5525391496652 -0.009763345103347199 SGYIS(ph)ESENSEISQQVR ddPTM_A459_Selumetinib_30min_R2 1 SGYISESENSEISQQVR 17 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 SGYIS(0.784)ES(0.216)ENSEISQQVR 176.85 9.1945e-08 7147900.0 10614.0 8354.1 11337.0 7558.2 10265.0 5821.0 7252.2 8415.2 7969.1 9537.0 True False 10024.116371208476 8994.83260733469 10607.589762792308 6528.760121377758 8975.418929735662 6622.7899122231265 7589.441669961673 8439.68683878864 9563.142675258106 9261.642029898172 1.0823260431410442 0.9711919957927359 1.1453249573400899 0.7049246883329974 0.9690958580305163 0.715077293080819 0.8194488240272785 0.9112516777849847 1.0325536923567806 1.0 13.177052281428265 -5.746422453538724 24.999477121597288 0.8696637148861447 1.0567720903848659 0.369145640184382 0.11158545008419886 255.9242740472215 426047.2305792285 0.029747966983027146 0.05126373286211461 1.792988675047467e-06 5.746422453538724 0.18710837549872117 SGYISES(ph)ENSEISQQVR ddPTM_A459_Selumetinib_30min_R1 4 SGYISESENSEISQQVR 17 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 SGYIS(0.141)ES(0.859)ENSEISQQVR;SGYIS(0.052)ES(0.93)ENS(0.018)EISQQVR;SGYIS(0.447)ES(0.552)ENS(0.001)EISQQVR;SGYIS(0.402)ES(0.595)ENS(0.003)EISQQVR 289.5 1.0535999999999995e-75 23373300.0 4912.700000000001 9004.220000000001 5972.27 8499.119999999999 7399.14 6135.0 6144.429999999999 5223.2 3100.19 4647.389999999999 True False 5027.156351549842 7950.001736451685 5161.268537330872 7014.908240241579 6729.889093424267 6073.287470134312 5680.950698191027 5084.663768655287 5260.7960010811385 5243.927775912071 0.958662393224032 1.5160395177389623 0.9842371515944797 1.3377202242304878 1.2833679983805162 1.158156200783675 1.0833388522790905 0.969628870941289 1.0032167157691514 1.0 12.356432100265417 -7.345247146911642 2.0776308850652203 0.9907085695774527 1.2252746677118291 0.28986372782588676 0.15260918890267108 0.39098738052428667 3.293710361814539 0.07495345064742709 0.044976873075967025 4.51598876795045e-08 7.345247146911642 0.23456609813437646 SGYISES(ph)ENSEISQQVR ddPTM_A459_Selumetinib_30min_R2 1 SGYISESENSEISQQVR 17 0 A0A075B754;Q96QE3;Q96QE3-2 A0A075B754 ATAD5 ATPase family AAA domain-containing protein 5 1 SGYIS(0.045)ES(0.955)ENSEISQQVR 308.25 5.431899999999998e-103 9141200.0 36544.0 40940.0 46979.0 33819.0 37276.0 29410.0 34086.0 36022.0 28591.0 44497.0 True False 34513.03077722281 44079.966357151825 43956.42228686772 29212.793858970956 32593.055628331877 33460.9605426013 35671.06654012763 36126.81805623687 34309.99889928658 43212.25599290961 0.7986861593823245 1.0200801912398323 1.017221185908003 0.6760302878832403 0.754254895501865 0.7743395889372605 0.8254849398740172 0.8360317513199187 0.7939876803681867 1.0 15.399152931579197 -5.747592565141486 24.99517422355937 0.7987707613754096 0.9528042827841106 0.29304965988629184 0.09627560912915366 260.16138695994107 469618.71994109143 0.025450999645185938 0.043795565662932336 1.7881643607191005e-06 5.747592565141486 0.15403352140870097 SGYMS(ph)DSDLMGK ddPTM_A459_Selumetinib_30min_R2 3 SGYMSDSDLMGK 12 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 S(0.002)GYMS(0.966)DS(0.032)DLMGK;SGYMS(0.99)DS(0.01)DLMGK;SGYMS(0.965)DS(0.034)DLMGK 117.7 0.0047014 3068000.0 269246.0 272282.0 302741.0 244438.0 255170.0 331931.0 217276.0 216519.0 181645.0 241862.0 True False 254282.38519713606 293165.1538753795 283262.97365947865 211145.12272093032 223113.2633512566 377651.4822803872 227379.76452422622 217149.03444335 217979.07558535566 234878.8156270559 1.0826109818302618 1.2481549393576281 1.2059962619585405 0.8989534546026905 0.9499079887456482 1.607856720803752 0.9680726800209313 0.9245151967563668 0.9280491090838353 1.0 17.84155707298057 -7.485984639808665 24.9988747957007 0.9450275484047348 1.1608076170355877 0.2422086431747531 0.18232290950342114 857.6170632181014 581109.4949209397 0.07884252781894571 0.053137093778493134 3.2659938318325413e-08 7.485984639808665 0.21578006863085286 SGYS(ph)SPGSPGTPGSR ddPTM_A459_Selumetinib_30min_R1 1 SGYSSPGSPGTPGSR 15 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SGYS(0.476)S(0.476)PGS(0.048)PGTPGSR 183.28 2.0847e-05 27425000.0 2760.1 3710.9 4286.7 4280.8 3944.5 3480.1 4016.3 3350.4 1857.4 2491.0 True False 2824.4049597803073 3276.426102849392 3704.589685157608 3533.238640568217 3587.720671458037 3445.0933536779826 3713.34725745832 3261.5365083670304 3151.872140871402 2810.7441143947403 1.0048602237804591 1.165679254141187 1.3180102970545031 1.257047421169841 1.2764309113320367 1.2256872961272185 1.321126045747478 1.160381868866552 1.1213657354042417 1.0 11.456736403731705 -8.46032354382018 1.8013591331312522 1.0040196703807938 1.2280124181131136 0.3794026344052718 0.08741586590518785 0.3639061405245747 2.584695467354808 0.08676368384060253 0.02485009291101842 3.464786321416626e-09 8.46032354382018 0.2239927477323198 SGYSS(ph)PGSPGTPGSR ddPTM_A459_Selumetinib_30min_R1 4 SGYSSPGSPGTPGSR 15 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 S(0.003)GYS(0.113)S(0.83)PGS(0.053)PGT(0.001)PGSR;SGYS(0.017)S(0.718)PGS(0.262)PGT(0.002)PGSR;SGYS(0.076)S(0.896)PGS(0.028)PGTPGSR;SGYS(0.031)S(0.556)PGS(0.41)PGT(0.003)PGSR 185.32 2.1003e-05 39492500.0 8400.3 9521.900000000001 9621.3 10126.1 9500.2 8490.9 9230.5 8512.3 4880.240000000001 7796.700000000001 True False 8596.010645861568 8407.071521388785 8314.7803060179 8357.766725438663 8640.90858739654 8405.489255120365 8534.235953481817 8286.526152152781 8281.410841373025 8797.48239128923 0.9770989316640011 0.9556224323578064 0.9451317929605322 0.9500180112567264 0.9822024305444793 0.9554425779178604 0.9700770713598627 0.9419201748397509 0.9413387231752587 1.0 13.102875005995637 -11.107224258219512 6.607343557027111 1.0000761063868604 0.9575579685138338 0.4628719198394742 0.01368580712978577 1.576188207891774e-05 9.915487127999236e-07 0.013612596943838247 0.003295634127047689 7.812242967884014e-12 11.107224258219512 -0.04251813787302661 SGYSS(ph)PGSPGTPGSR ddPTM_A459_Selumetinib_30min_R2 4 SGYSSPGSPGTPGSR 15 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SGYS(0.034)S(0.825)PGS(0.14)PGTPGSR;SGYS(0.101)S(0.795)PGS(0.101)PGT(0.004)PGSR;SGYS(0.047)S(0.891)PGS(0.061)PGTPGSR;SGYS(0.048)S(0.912)PGS(0.04)PGTPGSR 160.46 0.00012877 43850100.0 105208.0 98325.0 118569.0 112801.0 117662.0 86619.0 86674.0 92611.0 81809.0 101485.0 True False 99360.96054099318 105866.2113352944 110940.39962816644 97437.30920742147 102880.2476483739 98549.98100100578 90704.51274127285 92880.48267742369 98173.08593444564 98554.86436030373 1.0081791617889349 1.0741855515955188 1.125671475966755 0.9886605784490086 1.043888075095483 0.9999504503473304 0.9203453663095611 0.9424241338090097 0.9961262345766886 1.0 16.588639459497017 -6.735863183328632 1.6240701619534763 0.9600353897651803 1.057525106086089 0.4658307143646364 0.04141173936654176 0.31379194818803763 1.7164227047827192 0.018140004590619273 0.016840473631870852 1.837117002890444e-07 6.735863183328632 0.09748971632090875 SGYSSPGS(ph)PGTPGSR ddPTM_A459_Selumetinib_30min_R1 1 SGYSSPGSPGTPGSR 15 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SGYS(0.001)S(0.005)PGS(0.749)PGT(0.24)PGS(0.006)R 87.51899999999998 0.018573 3832900.0 1743.5 1813.5 2282.0 1721.8 1953.8 1449.2 2004.7 1709.9 958.3 1506.8 True False 1784.1201577395618 1601.1745769267227 1972.1169341287382 1421.1199521889273 1777.0791349714054 1434.6223637683197 1853.4838650067702 1664.5478974620303 1626.1651085372362 1700.2124574749078 1.049351303065542 0.9417497030369532 1.159923823318912 0.8358484529042457 1.045210042520602 0.8437900554492863 1.0901483851962215 0.9790234685929515 0.9564481788072274 1.0 10.731499320550899 -5.756231031347366 24.999998815253036 0.9670657424118577 1.039482359123533 0.16038275233156796 0.0889754916498663 272.7630771884573 1309239.1894346727 0.023023885521125147 0.038375372431529046 1.7529477393174945e-06 5.756231031347366 0.07241661671167521 SGYSSPGS(ph)PGTPGSR ddPTM_A459_Selumetinib_30min_R2 1 SGYSSPGSPGTPGSR 15 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SGYS(0.001)S(0.014)PGS(0.934)PGT(0.051)PGSR 119.77 0.0018689 2033000.0 12208.0 13235.0 12257.0 12228.0 11988.0 10415.0 9146.7 10465.0 8590.3 12386.0 True False 11529.528232496057 14250.08194276758 11468.39796441256 10562.525305523433 10481.960265920234 11849.571712043276 9572.039673842213 10495.451417425991 10308.60003303632 12028.38399730719 0.9585267842361191 1.184704607531466 0.9534446162493652 0.8781333642065368 0.8714354536957619 0.985134138941362 0.7957876698968971 0.872557063340813 0.8570228582113874 1.0 13.554155210286659 -5.484111513144697 6.189107496966405 0.889443586896319 1.0726415495977493 0.4599936190205909 0.0758763300314271 0.1526612043495688 16.450650347336595 0.018970919253618997 0.03872887426016898 3.2801105939006937e-06 5.484111513144697 0.1831979627014303 SGYSSPGSPGT(ph)PGSR ddPTM_A459_Selumetinib_30min_R2 1 SGYSSPGSPGTPGSR 15 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SGYSSPGS(0.11)PGT(0.888)PGS(0.002)R 119.62 0.0044137 1928200.0 13259.0 10664.0 15859.0 16685.0 12502.0 8949.0 9685.7 10426.0 6857.8 13189.0 True False 12522.117859982402 11481.894509835543 14838.649205973643 14412.474216769591 10931.386990701923 10181.643519066274 10136.10424185045 10456.337933882784 8229.55162294174 12808.199300862643 0.9776641950862699 0.8964487700517143 1.1585273509114 1.1252537439668744 0.8534679023901264 0.7949316902322509 0.7913762117339769 0.8163784532286705 0.6425221398910832 1.0 13.644780041620654 -6.413558945652568 4.9423266630355585 0.7989887070665688 1.0366571199745676 0.5185796521317743 0.10559008435020291 0.18419944044829567 6.856298388481381 0.03380210837076687 0.03822768335443914 3.8587003491112837e-07 6.413558945652568 0.23766841290799878 SHDDGNIDLESDS(ph)FLKFDSEPSAVALELPTR ddPTM_A459_Selumetinib_30min_R1 1 SHDDGNIDLESDSFLKFDSEPSAVALELPTR 31 1 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;P18583-8 P18583-10 SON Protein SON 1 SHDDGNIDLES(0.222)DS(0.772)FLKFDS(0.005)EPSAVALELPTR 78.274 9.2866e-06 4293100.0 306.47 391.32 412.32 453.61 433.83 337.4 366.34 297.64 255.03 307.79 True False 313.6101547131884 345.5040724802676 356.3292087116398 374.3955288142751 394.5901530989076 334.0060623346889 338.7066788579737 289.74562032902435 432.7672833457703 347.29784462848556 0.9030005787933011 0.9948350610982432 1.0260046649377146 1.0780243373372407 1.136172191108793 0.9617280023490636 0.9752628301517331 0.8342856853574013 1.2460983851158474 1.0 8.440029646986396 -4.774323684803802 2.51959421734947 1.0267750779116585 0.8747180079442506 0.12303559751473514 0.10361772216420478 1.2345702226857056 9.818094500426614 0.026690510483959647 0.41284161082546256 1.6814204114683165e-05 4.774323684803802 -0.15205706996740787 SHEAEVLK ddPTM_A459_Selumetinib_30min_R1 1 SHEAEVLK 8 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 0 112.84 0.015456 5693300.0 3661.8 4032.8 4399.6 4019.0 4114.7 4040.3 3719.2 3682.5 2989.3 3068.2 False True 3747.112815377534 3560.637901202146 3802.15848527292 3317.1570959735727 3742.5261115092876 3999.658250298885 3438.657749654902 3584.8281375542015 5072.6237701662985 3462.0333567988528 1.0823445152597484 1.0284816852528733 1.0982443244823505 0.9581528408613489 1.0810196568902475 1.155291656114239 0.9932480121550403 1.0354689767833116 1.4652151632809998 1.0 11.757403909845104 SHEAEVLK ddPTM_A459_Selumetinib_30min_R2 2 SHEAEVLK 8 0 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 0 ; 108.98 0.017768 4098300.0 65956.0 53564.0 55224.0 63999.0 62861.0 48242.0 60115.0 65844.0 53084.0 77695.0 False True 62290.42956278755 57672.1865645941 51670.94796334497 55282.22579556704 54963.839195529814 54886.89760272604 62910.46661561264 66035.59513893895 63702.28329088625 75451.74347414666 0.8255664706294189 0.7643585675969876 0.684821126513132 0.7326832124761882 0.7284634743312861 0.7274437286069194 0.8337841343211473 0.8752030383706889 0.8442784799626754 1.0 16.203266617245667 -8.227913178666263 0.7255820943912177 0.989987410215495 0.7384318175905668 0.7625318420729224 0.04326711721282335 0.31671842756548074 0.3684255073920844 0.04405679180122962 0.018266174401019453 5.916799071592328e-09 8.227913178666263 -0.2515555926249282 SHEGETAYIR ddPTM_A459_Selumetinib_30min_R1 2 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 ; 210.64 0.00026129 34445000.0 1013.92 1181.6 1217.98 1464.32 1193.48 1022.99 1000.79 1170.34 568.75 852.6 False True 1037.542363255117 1043.2577226890635 1052.5850058852423 1208.6040006907238 1085.5299447260077 1012.6996494006027 925.2996045593485 1139.2987813999146 965.1272101435396 962.0395150272808 1.0784820654957141 1.0844229435414403 1.0941182658753823 1.2562935116614737 1.1283631574065074 1.0526590993218041 0.9618103935503206 1.1842536232699414 1.0032095304486233 1.0 9.909952342567443 -6.767333722823361 6.519923882374181 1.0466431121474702 1.1313302010993302 0.26816735401775615 0.07225134144361778 0.22687482356450847 42.04715333835919 0.02561444680530443 0.023799900848489215 1.7087018009660658e-07 6.767333722823361 0.08468708895186006 SHEGETAYIR ddPTM_A459_Selumetinib_30min_R2 3 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 ;; 180.09 0.00016585 30516600.0 10137.67 8076.38 12562.1 9859.8 11116.2 9859.5 9514.7 11086.6 7030.900000000001 11230.3 False True 9574.258885708417 8695.812376345235 11753.86816258032 8516.878230896302 9719.683575911118 11217.556629370192 9957.152403020375 11118.860170514572 8437.276459759849 10906.052059176409 0.8778849425766848 0.7973382420294366 1.0777381309756866 0.7809313750460375 0.8912192536008414 1.0285625420182807 0.9129932948231596 1.0195128457285425 0.773632512845075 1.0 13.412841326726314 -6.5594178848353115 24.93756330952184 0.9475773427202054 0.8843064467786774 0.08652676139077842 0.10081728054593253 441.4648678028515 301292.0782371887 0.031994545863345616 0.03199464902632022 2.75792286325763e-07 6.5594178848353115 -0.06327089594152802 SHEGETSYIR ddPTM_A459_Selumetinib_30min_R1 1 SHEGETSYIR 10 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 152.04 0.0021929 0.0 237.04 358.8 300.24 468.16 574.95 353.16 399.96 364.05 65.42699999999999 212.25 False True 242.56257080045074 316.79152919840544 259.4690571002685 386.4046444516017 522.9458740156671 349.60753104362396 369.7906951903564 354.3942113989428 111.02484040098692 239.49435499007777 1.0128112239242553 1.322751549661912 1.0834036447790942 1.6134185896265087 2.1835415454252884 1.4597735761166821 1.5440476465747046 1.4797601864713066 0.4635801975607595 1.0 7.903847841043907 -8.248078484036483 24.208672252011887 0.7317901404880515 1.476848731801664 0.44560292616773167 0.3256732676733262 423.37457273880426 767119.5735294286 0.2380870162703115 0.08873790724188618 5.648348907889368e-09 8.248078484036483 0.7450585913136126 SHELDIDENPAS(ph)DFDDSGSLLGFK ddPTM_A459_Selumetinib_30min_R1 1 SHELDIDENPASDFDDSGSLLGFK 24 0 Q96RS0 Q96RS0 TGS1 Trimethylguanosine synthase 1 SHELDIDENPAS(0.982)DFDDS(0.015)GS(0.003)LLGFK 69.054 0.0012212 6108400.0 1105.4 1499.8 1257.8 1553.3 1266.6 1049.8 1306.8 1188.5 674.86 1110.0 True False 1131.1536692660243 1324.202718761897 1086.9976686008451 1282.0453140521897 1152.0362536363918 1039.2399651421354 1208.2270238892843 1156.9771192079209 1145.1881301757694 1252.4793123156014 0.903131619136073 1.0572651426183577 0.867876744879074 1.0236059801115007 0.9198046165780502 0.8297462121116985 0.9646682480172045 0.9237494845874022 0.914336962626975 1.0 10.290571058728338 -4.429401153830932 14.741197060115226 0.9409707530809515 3.495468994616058e-05 0.031753292111675546 0.06600496866132836 557293.2914428151 1356769.556407442 0.01593567666412167 16819659.602316562 3.72047890264207e-05 4.429401153830932 -0.9409357983910053 SHESNAPGS(ph)AGGQASEKPR ddPTM_A459_Selumetinib_30min_R2 2 SHESNAPGSAGGQASEKPR 19 1 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 SHESNAPGS(1)AGGQASEKPR;SHESNAPGS(1)AGGQASEKPR 131.77 0.00014331 2415700.0 3027.08 3518.9 8634.1 13874.400000000001 13471.300000000001 9904.4 8026.0 6629.299999999999 6939.9 14298.4 True False 2858.8470119613507 3788.7883149531413 8078.591406097288 11984.682785325023 11778.914859049983 11268.641196808578 8399.224903217284 6648.5901654603 8328.073917007407 13885.56804029527 0.20588621248083697 0.27285799932406474 0.5817976897058582 0.863103529545643 0.8482846956543746 0.811536205368589 0.6048888226137473 0.47881297662194316 0.5997647264296084 1.0 13.761298576666904 -5.328478820412809 3.0051861554604056 0.7235591912917596 0.22050231380544674 0.6507269509701333 0.145470824229363 0.1733422680326273 3.038175584572695 0.042892802795477906 0.11374606216098308 4.6937632421056675e-06 5.328478820412809 -0.5030568774863129 SHGLEPAAPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SHGLEPAAPSPR 12 0 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 SHGLEPAAPS(1)PR;SHGLEPAAPS(1)PR 112.5 0.0042011 21365300.0 4534.9 6116.5 5632.1 6289.7 5981.6 5437.4 5590.6 5093.0 3078.3 4401.8 True False 4640.554346620675 5400.377336516294 4867.291754910812 5191.321967291608 5440.565336137255 5382.704692764189 5168.896540982119 4957.917095604494 5223.650269863484 4966.813907162893 0.9343121029616787 1.0872920623678164 0.979962576792226 1.0452016250910752 1.0953833660429961 1.0837339174317602 1.0406865724378747 0.9982087487623467 1.0517104863401856 1.0 12.27810497864024 -4.7466222002418235 24.97349520654899 1.0434285872670763 0.9343118125349852 0.42406612548404676 0.03779668009074113 813.3904892938618 1370845.0569293457 0.009624386315851875 0.2156078851724486 1.792164208601503e-05 4.7466222002418235 -0.10911677473209114 SHGLEPAAPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SHGLEPAAPSPR 12 0 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 SHGLEPAAPS(1)PR 77.74600000000002 0.029942 2795900.0 22089.0 15634.0 19354.0 19499.0 19388.0 15199.0 17384.0 18003.0 15046.0 19326.0 True False 20861.38180927305 16833.077528766768 18108.78471104192 16843.20256234883 16952.306109080855 17292.524287215136 18192.3904457425 18055.385749442907 18055.62042036534 18768.0081650217 1.1115394678990396 0.8969027176863072 0.9648751509385857 0.8974422013381171 0.9032554738906815 0.921383033040424 0.9693298450097657 0.9620299389624669 0.9620424427359292 1.0 14.195987925673103 -10.13373899296483 14.21656600569147 0.9999999998032839 0.9494593875108911 0.044716074753804236 0.059673997569337875 0.0 0.0 0.05575317581929346 0.013522131345092907 7.349554369900705e-11 10.13373899296483 -0.05054061229239282 SHGS(ph)PAPSTSSTCR ddPTM_A459_Selumetinib_30min_R2 2 SHGSPAPSTSSTCR 14 0 Q14123;A0A0A0MS69;Q14123-3 Q14123 PDE1C Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C 1 S(0.078)HGS(0.922)PAPSTSSTCR;S(0.025)HGS(0.975)PAPSTSSTCR 88.95100000000002 0.01332 1990760.0 3831.1 1926.54 2490.7 3017.1 1917.58 1745.74 1664.5 1466.04 2794.15 1720.6100000000001 True False 3618.1827991084238 2074.299423197539 2330.451073669116 2606.1657752121964 1676.6764570172927 1986.1998387501108 1741.9025481441781 1470.3059336840136 3353.0580750740282 1670.9315186183383 2.165368693326361 1.2414030138785928 1.394701726373635 1.5597083101090736 1.0034381650803408 1.1886781813730236 1.04247393069976 0.8799318926605573 2.006699878308962 1.0 10.706436891924593 -2.916957988004313 1.4500254105423254 1.2334758632677638 199.99999755672926 0.41263542835360933 0.3195044441716201 297.1716406669778 3.828295842891893 0.0878136744582712 193611.4047633414 0.0012107152478720966 2.916957988004313 198.7665216934615 SHHAPMS(ph)PGSSGGGGQPLAR ddPTM_A459_Selumetinib_30min_R1 1 SHHAPMSPGSSGGGGQPLAR 20 0 O14497-2;O14497 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 SHHAPMS(0.994)PGS(0.004)S(0.002)GGGGQPLAR 88.04 0.0038131 1486800.0 589.29 715.85 617.25 831.33 1091.5 705.26 1042.9 761.21 270.59 210.87 True False 603.019310441266 632.0379492103636 533.4308403115532 686.1538214968173 992.7740177199771 698.1657247248454 964.2332133563928 741.0202380414484 459.17146688833475 237.9372185477395 2.5343631152865513 2.656322340271252 2.2418974365060342 2.883759950144782 4.172420034912646 2.9342434486968085 4.052469047262272 3.114351939407793 1.92980093526733 1.0 7.894437148021592 -5.982820772452654 16.47819430583664 3.0803148456160394 2.5066151974195154 0.006035809552465854 0.8890963224654036 12.880836053636461 12345.803931743438 0.2430100344045709 0.3596504826217211 1.040349415595222e-06 5.982820772452654 -0.573699648196524 SHHAPMS(ph)PGSSGGGGQPLAR ddPTM_A459_Selumetinib_30min_R2 4 SHHAPMSPGSSGGGGQPLAR 20 0 O14497-2;O14497 O14497-2 ARID1A AT-rich interactive domain-containing protein 1A 1 S(0.003)HHAPMS(0.997)PGSSGGGGQPLAR;SHHAPMS(1)PGSSGGGGQPLAR;S(0.006)HHAPMS(0.992)PGS(0.001)SGGGGQPLAR;S(0.015)HHAPMS(0.952)PGS(0.02)S(0.012)GGGGQPLAR 104.97 0.00094938 6665630.0 17891.82 16188.81 28780.0 28970.4 46738.8 25479.5 16055.060000000001 22201.6 24221.8 24807.7 True False 16897.464271030272 17430.439671771448 26928.32613329473 25024.581543272485 40867.05409382651 28989.069845127855 16801.652102497865 22266.202980327264 29066.836813638518 24091.437242854652 0.70138880053916 0.7235118227303434 1.1177550704776436 1.038733442551029 1.696331093984332 1.2032935002134755 0.6974117788460759 0.9242372198832288 1.2065214922891134 1.0 14.556232843747974 -5.255449347425618 6.632380326699347 1.115198934079969 0.7095427158358913 0.30259302391555976 0.2416882962651343 0.18251106271265957 46.39789484692488 0.06872137536302243 0.16673991060221505 5.5532938244292326e-06 5.255449347425618 -0.4056562182440777 SHHLDEDEERER ddPTM_A459_Selumetinib_30min_R1 1 SHHLDEDEERER 12 1 F5GWA4;Q9H3F6-2;Q9H3F6;F5GWK6;F5H268;B3KVY5;Q9H3F6-3 F5GWA4 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 0 104.43 0.007790000000000002 2417500.0 1314.4 1183.7 1223.5 1288.7 1503.7 1173.4 1330.9 1159.1 484.01 641.46 False True 1345.0229626228165 1045.1118537128 1057.3554202044309 1063.652736895034 1367.690600499798 1161.5966613619566 1230.509141486263 1128.3569027125789 821.3296193082627 723.7976393495182 1.8582859206774944 1.4439282430543003 1.4608439745046464 1.4695443575236662 1.8896035661693378 1.6048638434437164 1.700073438471186 1.5589397386355677 1.1347503427151229 1.0 9.499442592173907 -8.304651959683962 3.000569368846449 1.0078513091856212 1.6227539244051865 0.7017616663201252 0.14676210099342718 0.14458369316184946 2.4384090033962313 0.14048099114793286 0.039223678042278144 4.958473999827751e-09 8.304651959683962 0.6149026152195654 SHIAQWS(ph)PHTPPR ddPTM_A459_Selumetinib_30min_R1 1 SHIAQWSPHTPPR 13 0 P40189-3;P40189 P40189-3 IL6ST Interleukin-6 receptor subunit beta 1 SHIAQWS(0.943)PHT(0.057)PPR 69.805 0.041527 8011400.0 2613.4 2735.2 3256.7 2838.0 3445.8 2572.4 2653.3 2677.5 1404.8 2381.1 True False 2674.2871352088187 2414.961512440016 2814.458027772596 2342.3965758579257 3134.1279984053995 2546.523991552325 2453.159444815916 2606.4840022542767 2383.8429974675064 2686.7373788780883 0.9953660362314725 0.8988453919707037 1.0475374518918705 0.871836821221451 1.1665181803939952 0.9478127678469591 0.9130626104737827 0.9701298023190776 0.8872631230012281 1.0 11.39163959346871 -10.073346748060331 6.232574091239496 1.000000000037644 0.9679664583473772 0.01387133030875265 0.08394165075035234 0.0 0.0 0.07801922470131427 0.01892244142778337 8.44604229580722e-11 10.073346748060331 -0.03203354169026695 SHIAQWS(ph)PHTPPR ddPTM_A459_Selumetinib_30min_R2 2 SHIAQWSPHTPPR 13 0 P40189-3;P40189 P40189-3 IL6ST Interleukin-6 receptor subunit beta 1 SHIAQWS(0.684)PHT(0.316)PPR;SHIAQWS(0.999)PHT(0.001)PPR 106.19 0.0057683 12165000.0 59342.0 30429.0 43824.0 41627.0 43588.0 30055.0 48798.0 38034.0 32757.0 32538.0 True False 56044.009204847745 32762.806455343754 41004.41155196346 35957.330789419706 38112.08575833592 34194.803437874274 51067.203691402596 38144.67264313235 39309.315307052224 31598.543396123157 1.7736263505020873 1.0368454660908022 1.2976677765784075 1.13794266838994 1.2061342600688332 1.08216391525407 1.6161252451170918 1.2071655381371895 1.2440230175886875 1.0 14.947570435305497 SHIAS(ph)PSPCPDR ddPTM_A459_Selumetinib_30min_R1 1 SHIASPSPCPDR 12 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 S(0.077)HIAS(0.916)PS(0.007)PCPDR 150.51 0.00054734 7627400.0 1514.5 1626.5 1665.4 1633.4 1781.3 1248.4 1713.8 1255.8 756.49 1153.9 True False 1549.784903295995 1436.068623860664 1439.2478273873812 1348.1573527154098 1620.1817295140577 1235.8422294565075 1584.5266862117037 1222.4921045867113 1283.7082781564584 1302.0143049378128 1.1902979079557934 1.1029591751906704 1.1054009329460655 1.035439739488731 1.2443655368221482 0.9491771517176489 1.2169810118079958 0.9389237122437764 0.9859402260697675 1.0 10.346529583818072 -7.7800659487797486 24.99772049004753 0.971823922736489 1.1142772018511704 0.3908074884455409 0.08306989768744108 249.6572086778953 335046.70327348623 0.041915724443359 0.020192298400388213 1.6593349138561372e-08 7.7800659487797486 0.14245327911468142 SHIAS(ph)PSPCPDR ddPTM_A459_Selumetinib_30min_R2 2 SHIASPSPCPDR 12 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 S(0.156)HIAS(0.841)PS(0.003)PCPDR;SHIAS(0.947)PS(0.053)PCPDR 149.41 0.00057682 15683100.0 58284.0 49206.0 65465.0 66620.0 75211.0 56333.0 47489.0 49860.0 50754.0 52431.0 True False 55044.80860933818 52979.941977772694 61253.053172902684 57546.241074089834 65762.32178512892 64092.359409940764 49697.33259766829 50005.084345232644 60906.21818524673 50917.180797901965 1.081065521436063 1.0405120854600758 1.2029938070614195 1.1301929952190326 1.2915546531562614 1.2587570326081698 0.9760425031174558 0.9820866662612455 1.1961820593915593 1.0 15.635864921304774 -10.736537558983564 4.60554178935247 0.9999693448396036 1.1282441680598465 0.12111232983524389 0.10409653743073699 3.54862929251226e-05 6.059165735838597e-06 0.10915782509479201 0.026468337129101956 1.8342665278341014e-11 10.736537558983564 0.12827482322024286 SHIASPS(ph)PCPDR ddPTM_A459_Selumetinib_30min_R2 1 SHIASPSPCPDR 12 0 A6NF31;O75665-3;O75665 A6NF31 OFD1 Oral-facial-digital syndrome 1 protein 1 SHIAS(0.305)PS(0.695)PCPDR 170.18 0.00031719 12520000.0 31016.0 23399.0 32883.0 37488.0 42768.0 28481.0 23041.0 25049.0 25844.0 34824.0 True False 29292.254886885472 25193.628060356532 30767.343580303346 32382.06972959294 37395.10148922893 32403.999225223644 24112.452154875336 25121.888442914802 31013.522141693593 33818.54063638186 0.8661596371598889 0.7449649685135532 0.9097773884188235 0.9575241604233042 1.1057573977334616 0.9581726063709426 0.7129950524516498 0.7428436582472978 0.9170567847723553 1.0 15.045526784357033 -10.422640087698358 17.37290552682158 0.9999999999999979 0.8787585351303784 0.09104739115166349 0.11422690746619006 0.0 0.0 0.12401996888312371 0.03007926067005498 3.778852255290281e-11 10.422640087698358 -0.12124146486961951 SHIEIIR ddPTM_A459_Selumetinib_30min_R1 1 SHIEIIR 7 0 P00390-5;P00390-4;P00390-2;P00390-3;P00390 P00390-5 GSR Glutathione reductase, mitochondrial 0 124.08 0.013136000000000002 0.0 3579.2 3280.9 3437.8 3689.2 3661.8 3156.1 3212.0 4115.5 2069.4 2637.9 False True 3662.5883960891547 2896.770702750972 2970.9656424836908 3044.9504748608356 3330.590836543299 3124.3524995095213 2969.716254003963 4006.343570971977 3511.620657004028 2976.5001603219125 1.230501662628179 0.9732136894753878 0.9981405954845898 1.0229969127673488 1.1189620887448872 1.0496732172766348 0.9977208446321012 1.345991384236541 1.1797817798955677 1.0 11.53940125673536 -7.734339810145128 24.999932406260246 1.1971652176363037 1.0514082016470596 0.20398041334800587 0.10517033064249658 258.2777737093831 238267.0784135784 0.047389106296434655 0.02735129418826402 1.843572366666595e-08 7.734339810145128 -0.14575701598924407 SHILEDDENS(ph)VDISMLK ddPTM_A459_Selumetinib_30min_R1 9 SHILEDDENSVDISMLK 17 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 1 SHILEDDENS(1)VDISMLK;SHILEDDENS(1)VDISMLK;SHILEDDENS(0.998)VDIS(0.002)MLK;SHILEDDENS(1)VDISMLK;SHILEDDENS(1)VDISMLK;SHILEDDENS(0.988)VDIS(0.012)MLK;SHILEDDENS(0.989)VDIS(0.011)MLK;SHILEDDENS(1)VDISMLK;SHILEDDENS(1)VDISMLK 229.75 1.5349e-16 135258000.0 37948.67 47421.6 51031.6 52365.99999999999 43433.54 41789.3 45518.799999999996 42468.30999999999 25507.86 36612.7 True False 38832.800175742246 41869.45702629629 44101.789016513634 43221.26113156311 39504.983975814284 41368.93758364853 42085.28026860385 41341.9124622877 43284.975399616655 41312.29668289858 0.9399816348583028 1.0134865497233019 1.0675220831953838 1.0462081414479856 0.9562524271899789 1.0013710421665662 1.0187107386364518 1.000716875646407 1.0477504006097698 1.0 15.334283646011334 -4.764298443079241 6.316485544548425 1.0172525473999636 0.9376975259046358 0.37625896909333 0.029738435618437423 0.13911305527852125 24.380680655702434 0.007848038875493998 0.04784096161221536 1.7206857295786984e-05 4.764298443079241 -0.07955502149532778 SHILEDDENS(ph)VDISMLK ddPTM_A459_Selumetinib_30min_R2 3 SHILEDDENSVDISMLK 17 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 1 SHILEDDENS(0.932)VDIS(0.068)MLK;SHILEDDENS(1)VDISMLK;SHILEDDENS(1)VDISMLK 153.36 0.00021625 6082900.0 63970.0 59356.0 69831.0 71851.0 71284.0 69371.0 57998.0 65198.0 45991.2 63538.0 True False 60414.80349219959 63908.41434037872 65338.14948624404 62064.76985011159 62328.66663295446 78926.22556276074 60695.02192085675 65387.71538589008 55190.725101495846 61703.49284845028 0.97911480701075 1.0357341438894543 1.0589052008242195 1.0058550494466925 1.0101319026791509 1.279120871756987 0.9836561776159021 1.0597084924590672 0.8944505821906967 1.0 15.913064537846518 -10.43253933797367 6.17411415647381 0.9999999926212128 1.0397983388908936 0.008448860080904952 0.09383279108826201 9.403040597186285e-09 1.63238308206249e-09 0.09018105021515417 0.0218721133063662 3.693691857397745e-11 10.43253933797367 0.03979834626968082 SHISDQS(ph)PLSSK ddPTM_A459_Selumetinib_30min_R1 2 SHISDQSPLSSK 12 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SHISDQS(1)PLSSK;SHISDQS(1)PLSSK 250.05 2.2158e-18 72905000.0 13510.4 15373.3 12136.7 15261.9 25814.5 13435.2 23451.9 14055.2 3552.8900000000003 7750.6 True False 13825.166033337868 13573.386889146723 10488.60280212107 12596.695666344634 23479.58303292013 13300.05408618557 21682.904301767 13682.410438276109 6028.994837181329 8745.465007237202 1.5808382998384902 1.5520486192460015 1.199319052039126 1.4403688832921284 2.684772395005856 1.5207943860251312 2.479331205810506 1.564514914524659 0.6893852793638884 1.0 13.094319380735767 -8.15977993838079 4.900879691018694 0.8539591016254456 1.7753271345151895 0.4048186311903079 0.444995492621749 0.22340487350672775 8.202181415663343 0.3346408928789678 0.11875119380428746 6.921816178387837e-09 8.15977993838079 0.9213680328897439 SHISDQS(ph)PLSSK ddPTM_A459_Selumetinib_30min_R2 2 SHISDQSPLSSK 12 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SHISDQS(1)PLSSK;SHISDQS(0.988)PLS(0.009)S(0.002)K 125.33 0.0019129 86875000.0 318690.0 313700.0 510060.0 750350.0 921480.0 562440.0 388220.0 487120.0 597720.0 773260.0 True False 300978.4856171503 337759.78129551816 477243.2949113377 648151.0355740517 805715.4442642792 639911.0046780243 406272.99924333626 488537.43855294277 717280.7016921954 750933.9746292382 0.4008055245679271 0.4497862564578753 0.6355329643288133 0.8631265297246219 1.0729511135277752 0.852153486588445 0.5410235959079187 0.6505730930527552 0.9551847777913383 1.0 19.518326539749673 -5.462140846606766 2.622804742069171 0.8291589051247434 0.4190392252876616 0.5613622748792948 0.14960207761531563 0.23889175270965807 3.198405522851782 0.04635739289384811 0.11225535913443518 3.4503182347082387e-06 5.462140846606766 -0.41011967983708186 SHISDQS(ph)PLSSKR ddPTM_A459_Selumetinib_30min_R2 2 SHISDQSPLSSKR 13 1 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SHIS(0.294)DQS(0.647)PLS(0.055)S(0.003)KR;SHISDQS(0.996)PLS(0.003)SKR 78.249 0.021294 8500300.0 14485.4 17480.5 30293.0 40402.0 39160.0 22577.3 14061.599999999999 17705.7 20051.2 38548.0 True False 13680.359457650586 18821.198141333472 28343.981360524587 34899.17790266255 34240.37070515815 25687.118138676393 14715.492262531794 17757.22065566357 24062.000277338146 37435.019080267855 0.3654428338427522 0.5027698289929335 0.757151513660235 0.9322601873884991 0.914661500017944 0.6861788445625816 0.39309429042840766 0.4743478457320586 0.6427671433997297 1.0 15.192100869325497 -5.062593025133825 3.5421719610216584 0.7064077196047487 0.38276888513960455 0.2922054622301601 0.1846502769210903 0.3445541314162997 8.283972573829601 0.05377936964979357 0.1983598627514611 8.657788551500962e-06 5.062593025133825 -0.32363883446514413 SHISDQSPLS(ph)SK ddPTM_A459_Selumetinib_30min_R1 2 SHISDQSPLSSK 12 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SHISDQS(0.002)PLS(0.996)S(0.001)K;SHIS(0.001)DQS(0.244)PLS(0.585)S(0.17)K 243.3 1.2167e-13 45124300.0 7729.8 8581.5 7405.1 8639.1 13928.9 7624.599999999999 11787.2 6491.1 1945.48 4571.4 True False 7909.88930042746 7576.773990568888 6399.528093302682 7130.443360991616 12669.033454347029 7547.903446582898 10898.082014070833 6318.93494193566 3301.3374677627303 5158.183719206791 1.533464050722842 1.4688840884740764 1.2406553239803528 1.3823554470231458 2.456103571335228 1.4632870516957064 2.1127750788501785 1.2250309965515083 0.6400193648531773 1.0 12.332647443223168 -7.992863388008872 7.855222956211093 0.8546995935861154 1.6550816405812692 0.48236720329404403 0.3536781849515177 0.10735617553414004 49.893811403706195 0.21081560408673378 0.09534357921888117 1.0165684150891435e-08 7.992863388008872 0.8003820469951538 SHLDS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 1 SHLDSPEAR 9 0 K7ER08;K7EP90;Q9BTD8-4;Q9BTD8-2;Q9BTD8-3;Q9BTD8 K7ER08 RBM42 RNA-binding protein 42 1 SHLDS(1)PEAR 126.39 0.0048162 6514400.0 3455.6 3356.4 3220.9 4103.7 3333.4 2766.6 3253.3 3027.8 1798.7 2507.6 True False 3536.1087565728885 2963.4311276519743 2783.5194711372733 3387.0658309894866 3031.89455855957 2738.7705158718168 3007.900961753143 2947.4929083195125 3052.262528149775 2829.474886092434 1.2497402871302141 1.0473431456196935 0.9837583237861403 1.1970651683949376 1.0715396604020337 0.9679430375344726 1.0630597841803497 1.0417102207929698 1.0787381585015638 1.0 11.466318617039228 -6.52356564914386 24.99824363194709 1.0332559009199913 1.1083391938552265 0.23591508256788118 0.07450341376820512 42.06595851134298 1530827.286403096 0.02459934806164845 0.0248247082144775 2.995258786679917e-07 6.52356564914386 0.07508329293523519 SHLEPSGNPLPATPTTSAPSAPPAS(ph)SQGPDTAPRPSPPQEEAR ddPTM_A459_Selumetinib_30min_R2 2 SHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEAR 43 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 SHLEPSGNPLPAT(0.009)PT(0.011)T(0.011)S(0.011)APS(0.036)APPAS(0.406)S(0.406)QGPDT(0.096)APRPS(0.011)PPQEEAR;SHLEPSGNPLPATPT(0.001)T(0.001)S(0.001)APS(0.027)APPAS(0.372)S(0.372)QGPDT(0.127)APRPS(0.099)PPQEEAR 82.55 3.9425e-10 20512600.0 26342.2 22721.3 28679.7 28755.6 34023.0 23560.7 21682.4 28668.0 24630.9 26756.0 True False 24878.205980181643 24463.95064950546 26834.479326096356 24839.03767382315 29748.726570520845 26805.972562260005 22690.67456286053 28751.41913375713 29557.768244847586 25983.484759563315 0.9574622576760082 0.9415192333084351 1.0327513639686006 0.9559548268321112 1.1449090391761914 1.0316542530883572 0.8732729567580094 1.106526680305076 1.137559819953278 1.0 14.665307309496106 -5.468202126631408 1.3492662223890945 1.0412169104045612 0.9436583281357134 0.15888557941025394 0.07850639360170313 1.0830379980334854 3.495749693996867 0.02631774089293773 0.10214555725147756 3.4024979590483143e-06 5.468202126631408 -0.09755858226884784 SHLEPSGNPLPATPTTSAPSAPPASSQGPDT(ph)APRPSPPQEEAR ddPTM_A459_Selumetinib_30min_R2 1 SHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEAR 43 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 SHLEPSGNPLPATPTTSAPS(0.007)APPAS(0.159)S(0.159)QGPDT(0.478)APRPS(0.196)PPQEEAR 76.544 2.3532e-09 17633000.0 47216.0 40962.0 53236.0 54702.0 60208.0 36465.0 40343.0 40899.0 43473.0 44932.0 True False 44591.923740623664 44103.65368641067 49810.85371897423 47251.49323378664 52644.13277365077 41487.72275368775 42219.02943813793 41018.00931880606 52168.81473710905 43634.696412643854 1.0219372977624852 1.010747348150013 1.1415423462082512 1.082888094074026 1.2064741387405709 0.9507966403924839 0.967556392254497 0.9400319628881485 1.195581017540718 1.0 15.413188139227518 -6.793551825206986 24.99997109589164 1.0043429250923452 1.0903305482125305 0.18656636872720156 0.08492690024474679 337.5732679802868 262803.036497102 0.030279375543479776 0.026705875714738488 1.6086004090129688e-07 6.793551825206986 0.08598762312018526 SHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPS(ph)PPQEEAR ddPTM_A459_Selumetinib_30min_R1 2 SHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEAR 43 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 SHLEPSGNPLPATPTTSAPSAPPAS(0.003)S(0.003)QGPDT(0.019)APRPS(0.975)PPQEEAR;SHLEPSGNPLPATPTTSAPS(0.011)APPAS(0.121)S(0.121)QGPDT(0.093)APRPS(0.652)PPQEEAR 85.44200000000002 2.9564e-12 29042000.0 2555.5 3032.6 2521.3999999999996 2523.1 3006.9 2397.8 2633.6 2424.3999999999996 1172.35 2492.3 True False 2615.038177862606 2677.541782182507 2179.0077290588083 2082.4879494528295 2734.9264259113124 2373.680309028209 2434.9454316764773 2360.0970364389423 1989.3923249437862 2812.210982057814 0.9298869091070372 0.9521126968301775 0.7748379275100961 0.7405162566888864 0.9725182226228456 0.8440619584279152 0.8658473518564829 0.8392318540453033 0.7074121883586642 1.0 11.457489119239783 -7.820422024129743 5.273233522033566 0.828775955307395 0.8663182268965272 0.0 0.09563639800263192 0.9767212341610267 54.26889045747811 0.053484343950970646 0.0254327398995494 1.5120911650257296e-08 7.820422024129743 0.03754227158913215 SHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPS(ph)PPQEEAR ddPTM_A459_Selumetinib_30min_R2 1 SHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEAR 43 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 SHLEPSGNPLPAT(0.001)PT(0.002)T(0.002)S(0.003)APS(0.019)APPAS(0.131)S(0.131)QGPDT(0.355)APRPS(0.358)PPQEEAR 60.056 9.1774e-06 14940000.0 33093.0 27061.0 33799.0 27754.0 36655.0 25270.0 26561.0 30745.0 25875.0 32007.0 True False 31253.82354177521 29136.49168517063 31624.40913756875 23973.85732167953 32050.071200142324 28750.713121779496 27796.13912962301 30834.46285989127 31050.723007905995 31082.87474582684 1.00549977430808 0.9373808543587967 1.0174222750041682 0.7712882903438086 1.031116698896885 0.9249695646519807 0.8942589563198268 0.9920080787904304 0.9989656124736287 1.0 14.92383231925884 -7.898417939005769 9.293506403530014 0.9981236913716728 0.9395795422239334 0.12076704069319388 0.07027387176560371 0.5985180585025478 49.1858603474279 0.037183442050423565 0.01782798136973217 1.263519826384522e-08 7.898417939005769 -0.05854414914773942 SHNSWENSDDS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SHNSWENSDDSR 12 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 1 S(0.044)HNS(0.311)WENS(0.017)DDS(0.628)R 98.253 0.016829 0.0 5180.8 3961.2 5692.3 5831.2 5671.2 4688.5 4962.9 6224.5 6141.0 5775.7 True False 4892.871876385612 4265.011302734488 5326.063615307628 5036.980500618924 4958.733154828727 5334.29831703455 5193.684683799784 6242.612264478552 7369.371593876352 5608.940533929207 0.8723344180220841 0.7603951721247324 0.9495667823699646 0.8980270819684355 0.8840766139046595 0.9510349209029207 0.9259653676808505 1.1129752984037151 1.3138616017228333 1.0 12.453512572288629 -7.773672888304036 3.134085898611325 1.1739669665121497 0.8870112241228032 0.6415124301598951 0.08639977864953288 0.14449564133655798 2.8976083919805937 0.050473812476964725 0.023310431861866394 1.683941932827131e-08 7.773672888304036 -0.2869557423893465 SHNSWENSDDSR ddPTM_A459_Selumetinib_30min_R1 1 SHNSWENSDDSR 12 0 B5MBZ0;Q9HC35;Q9HC35-2 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 0 106.54 0.012445 680130.0 580.01 622.23 833.49 800.92 637.76 548.62 664.7 587.21 219.19 502.42 False True 593.5231044970027 549.379022333121 720.3066360328494 661.0543571304186 580.0747206056734 543.1013809071044 614.5611438469596 571.6352832731029 371.9494209958019 566.910500985229 1.0469432184895568 0.969075403222131 1.270582631263726 1.16606475974881 1.02322098390763 0.9580019773196177 1.084053202011462 1.008334264896598 0.6560990144818171 1.0 9.146977182479432 -8.056555408629038 7.760479570751689 0.8274445315358463 1.0727616329992007 0.4124164069252454 0.11582917194039884 0.2980545963187341 36.608768305446965 0.07862376862576206 0.029782988536752215 8.778990748804984e-09 8.056555408629038 0.2453171014633544 SHNVAAGS(ph)YEAPLPPGSFHGDFAYGTYR ddPTM_A459_Selumetinib_30min_R1 1 SHNVAAGSYEAPLPPGSFHGDFAYGTYR 28 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 1 S(0.002)HNVAAGS(0.511)Y(0.338)EAPLPPGS(0.146)FHGDFAYGT(0.002)YR 70.449 0.00024503 16194000.0 2534.5 2574.8 2759.7 2830.6 2746.5 2550.4 2226.5 2398.9 1581.5 2184.5 True False 2593.5489187214916 2273.3412190079544 2384.9478979470114 2336.2888469427203 2498.079559933958 2524.7452915779236 2058.553312434567 2335.2733792746158 2683.689991810124 2464.90185383192 1.0521915567102915 0.9222846806147 0.9675630265924735 0.9478222604728627 1.013460051583985 1.0242782233511534 0.8351461577402579 0.9474102896406261 1.0887613994196472 1.0 11.267314487935087 -8.247913812449557 24.682755579897886 1.0443807026408007 0.9613674353965795 0.21982696524943857 0.060609946856129075 858.2074480723483 1566149.0055826767 0.04164529825562907 0.015517599035955069 5.650491000355835e-09 8.247913812449557 -0.0830132672442212 SHNVAAGSY(ph)EAPLPPGSFHGDFAYGTYR ddPTM_A459_Selumetinib_30min_R1 1 SHNVAAGSYEAPLPPGSFHGDFAYGTYR 28 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 1 SHNVAAGS(0.002)Y(0.507)EAPLPPGS(0.481)FHGDFAY(0.001)GT(0.007)Y(0.001)R 87.052 0.00017622 6425900.0 1815.9 2289.3 3067.8 3028.2 2626.2 2694.3 2402.9 2438.1 1245.0 1726.6 True False 1858.206936873687 2021.2676917333051 2651.2096102191686 2499.3817163541107 2388.6606736932695 2667.197788228667 2221.647318414112 2373.43366793507 2112.6740687977253 1948.225928508214 0.9537943775835814 1.03749142343107 1.3608327306521577 1.282901371848554 1.2260696455889502 1.3690392624386127 1.1403437793866447 1.2182538139980734 1.084409173434742 1.0 10.927945275757033 -8.456156844987573 2.587472469020173 1.000150102177681 1.2068857042570824 0.21360823462583167 0.12402005962727758 0.4207272795336833 6.049560752605113 0.1266592757398747 0.03445388136386342 3.4981880752429563e-09 8.456156844987573 0.20673560207940134 SHNVAAGSYEAPLPPGS(ph)FHGDFAYGTYR ddPTM_A459_Selumetinib_30min_R2 2 SHNVAAGSYEAPLPPGSFHGDFAYGTYR 28 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 O15027 SEC16A Protein transport protein Sec16A 1 SHNVAAGS(0.001)Y(0.033)EAPLPPGS(0.964)FHGDFAYGT(0.001)YR;SHNVAAGS(0.006)Y(0.045)EAPLPPGS(0.944)FHGDFAY(0.001)GT(0.001)Y(0.001)R 120.23 2.088e-12 7273000.0 36798.5 35332.1 38852.9 40587.4 44472.6 33721.0 29581.7 34827.8 27353.7 38047.6 True False 34753.38668606703 38041.9584593924 36353.146713839036 35059.32610282973 38885.55439791158 38365.76166123967 30957.30766502652 34929.14313194733 32825.20432623605 36949.06692846319 0.9405754887762877 1.029578325564896 0.9838718467295018 0.9488555196998026 1.052409644692723 1.038341827021487 0.8378373322650537 0.9453322109479348 0.8883906159197115 1.0 15.173250312129921 -7.245557014368778 24.976950891209995 0.9133343837302368 0.9998006040680877 0.37300512876798375 0.05133554685102951 804.1977290325851 1264700.0531634672 0.019037043320170248 0.014695589444100394 5.6812380312364285e-08 7.245557014368778 0.0864662203378509 SHPAMS(ph)PGTPGPTMGR ddPTM_A459_Selumetinib_30min_R1 2 SHPAMSPGTPGPTMGR 16 0 A0A3F2YNW7;Q8NFD5;Q8NFD5-2;Q8NFD5-3;A0A1B0GUC6;A0A1B0GUG2;A0A1B0GU09;A0A6I8PTU7 A0A3F2YNW7 ARID1B AT-rich interactive domain-containing protein 1B 1 SHPAMS(0.98)PGT(0.019)PGPT(0.001)MGR;SHPAMS(0.945)PGT(0.055)PGPTMGR 153.41 0.0001436 5759000.0 1813.13 1943.07 1789.5 2295.2 2297.2200000000003 2116.92 1993.31 2148.44 1194.18 1636.95 True False 1855.3724012631685 1715.5744610912636 1546.495729019885 1894.386406239996 2089.4368566071334 2095.6257068095733 1842.9530218769119 2091.4563920833525 2026.436240543669 1847.068477743265 1.0044957312736176 0.9288093439758878 0.8372703815017093 1.0256178528662585 1.1312178632164154 1.1345684970867966 0.9977718985971861 1.1323112365810493 1.0971094277021902 1.0 10.851021638080052 -5.969636950887703 7.193620572148051 1.0865163140726342 0.924438099066729 0.5829338096700754 0.05993549686148605 0.12634902939920506 21.974761989852976 0.016901211129957523 0.024912637441009727 1.0724154178813965e-06 5.969636950887703 -0.16207821500590514 SHPAMS(ph)PGTPGPTMGR ddPTM_A459_Selumetinib_30min_R2 1 SHPAMSPGTPGPTMGR 16 0 A0A3F2YNW7;Q8NFD5;Q8NFD5-2;Q8NFD5-3;A0A1B0GUC6;A0A1B0GUG2;A0A1B0GU09;A0A6I8PTU7 A0A3F2YNW7 ARID1B AT-rich interactive domain-containing protein 1B 1 SHPAMS(0.994)PGT(0.006)PGPTMGR 89.604 0.008615000000000001 3685100.0 19680.0 20008.0 20198.0 22814.0 25590.0 14029.0 16497.0 19539.0 13988.0 19656.0 True False 18586.26438528197 21542.549264140067 18898.482669919642 19706.693843654848 22375.15542249738 15961.36740741766 17264.143188185353 19595.85525514442 16785.990857375407 19088.480207578737 0.9736901095930429 1.1285628310831675 0.9900464816688936 1.0323867395074575 1.1721810840453253 0.836178010708285 0.9044273300150389 1.0265801699270032 0.8793780685960966 1.0 14.220414621931297 -6.767191469062885 24.999999492511062 0.9294186554093823 1.0578665431074734 0.4273837787441418 0.07526275456065357 140.31171657258872 609825.8635439149 0.02563967208526441 0.023224627770425922 1.7092615802863953e-07 6.767191469062885 0.12844788769809112 SHPLDLS(ph)PNVQSR ddPTM_A459_Selumetinib_30min_R1 3 SHPLDLSPNVQSR 13 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2;H0YBM4 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 SHPLDLS(1)PNVQSR;SHPLDLS(1)PNVQSR;SHPLDLS(1)PNVQSR 187.08 0.00013811 28564500.0 9352.8 11217.5 11201.600000000002 12871.5 11793.2 9658.8 10441.6 9480.3 5982.3 8026.08 True False 9570.702042619201 9904.149885125727 9680.484245984444 10623.73415297931 10726.507142258564 9561.641241488725 9653.981705419606 9228.851647645639 10151.526170095292 9056.30554863964 1.0567998165716515 1.0936192282749826 1.0689220006980178 1.1730759409475882 1.1844241655329095 1.0557993201681444 1.065995582146601 1.0190525924814802 1.1209345925414549 1.0 13.144706918413908 -6.937266476419879 24.998614973552517 1.0541986724196626 1.115318412019152 0.30185004415523564 0.04788009825287049 90.96949621510055 36249.61967512678 0.017555309856193132 0.015482325742891885 1.1554030870729582e-07 6.937266476419879 0.06111973959948935 SHPLDLS(ph)PNVQSR ddPTM_A459_Selumetinib_30min_R2 2 SHPLDLSPNVQSR 13 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2;H0YBM4 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 SHPLDLS(1)PNVQSR;SHPLDLS(1)PNVQSR 151.11 0.00031383 42065000.0 103871.0 91103.0 106996.0 105737.0 100915.0 83546.0 86843.0 89620.0 73592.0 97147.0 True False 98098.26564855804 98090.30715768429 100111.99384843672 91335.43819350093 88237.15550845343 95053.7031449225 90881.37157613995 89880.77936261034 88312.45633228282 94342.11369178124 1.0398141594436634 1.03972980166788 1.0611591147459962 0.9681300812476683 0.9352891519552667 1.0075426490386472 0.9633171021909934 0.9527111047803505 0.9360873196121352 1.0 16.525614303699662 -5.769526140890919 24.897505464918236 0.9645038286137513 1.0461839046924433 0.7231727126299679 0.02287668382576984 82.83103451586804 255020.51113592292 0.006408490949614387 0.009695162776943515 1.7000976189229282e-06 5.769526140890919 0.08168007607869199 SHPLDPIDTVDFER ddPTM_A459_Selumetinib_30min_R2 1 SHPLDPIDTVDFER 14 0 A0A0U1RQL2;C9J165;A0A0U1RQT0;A0A1B0GVU9;P47897-2;P47897;A0A0U1RQM8;A0A0U1RQU2;A0A0U1RRI9;A0A0U1RQE9 A0A0U1RQL2 QARS Glutamine--tRNA ligase 0 85.90899999999998 0.033723 1402900.0 20929.0 23355.0 25205.0 18184.0 20767.0 31841.0 17853.0 14713.0 14035.0 23201.0 False True 19765.84996542514 25146.253401838818 23583.33774112904 15707.30783085036 18158.06380066445 36226.8087261805 18683.19987504837 14755.812394131724 16842.392170665138 22531.126846562587 0.8772685938005215 1.1160672776415177 1.0467003227016576 0.6971381386211809 0.8059101492935182 1.6078560549983039 0.829217286924055 0.654907874542587 0.7475166371110579 1.0 14.459631848262344 -7.5024800588727825 24.949307934792962 0.7691397332585125 1.0231546005073335 0.15756290254557226 0.24344208922086355 1292.6728752452293 1581053.5416869929 0.10602432754803194 0.0704927381652463 3.144270789729238e-08 7.5024800588727825 0.25401486724882105 SHS(ph)AGEVGEDSR ddPTM_A459_Selumetinib_30min_R1 1 SHSAGEVGEDSR 12 0 A0A2R8Y6F3;Q9P2P5;A0A2R8YE75 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 S(0.051)HS(0.949)AGEVGEDSR 115.8 0.0051666 1332600.0 398.34 428.98 586.59 525.53 463.62 602.32 498.34 517.23 257.39 378.81 True False 407.62054696528674 378.75482217260844 506.93429990822824 433.7560509198786 421.68565285875894 596.2612076628031 460.74981258416426 503.51138020017873 436.77203097819006 427.4339534218676 0.9536456888883942 0.886113092187569 1.1859944579739448 1.0147908172652143 0.9865516051846372 1.3949785759633064 1.0779438762306621 1.1779863910418562 1.021846831496575 1.0 8.739557703499512 -5.254819613176697 24.974234178123115 1.115447462554072 0.9198793724990001 0.28573790239768804 0.11813026395432705 619.5933406746694 2337508.826236324 0.03003176202719647 0.07563594097346507 5.561352034039294e-06 5.254819613176697 -0.19556809005507192 SHS(ph)AGEVGEDSR ddPTM_A459_Selumetinib_30min_R2 1 SHSAGEVGEDSR 12 0 A0A2R8Y6F3;Q9P2P5;A0A2R8YE75 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 S(0.023)HS(0.977)AGEVGEDSR 141.37 0.0009974 7000900.0 34358.0 31037.0 36283.0 39165.0 43557.0 24233.0 24072.0 28749.0 20473.0 33238.0 True False 32448.51990597146 33417.438100315645 33948.59128194347 33830.65943660658 38084.980255479444 27570.875784728243 25191.395697763102 28832.654830346844 24568.17206341486 32278.332577304765 1.0052724944282394 1.0352900980954574 1.0517455076292597 1.048091916011587 1.1798930494401496 0.8541604718489584 0.7804429066288089 0.8932510612589507 0.7611351052467004 1.0 14.978278433859511 -6.7947764203009875 17.714075278505465 0.8462846083841744 1.0608875217559233 0.6550230138960277 0.07459205350096741 4.890309332606702 2597.9118422595006 0.02511021487987986 0.02215751214854307 1.6040709719961027e-07 6.7947764203009875 0.21460291337174886 SHS(ph)APSEVGFSDAR ddPTM_A459_Selumetinib_30min_R1 2 SHSAPSEVGFSDAR 14 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 S(0.002)HS(0.998)APSEVGFSDAR;S(0.01)HS(0.99)APSEVGFSDAR 139.49 0.00037717 23626000.0 5804.700000000001 6522.8 7959.6 6621.9 6653.1 6534.1 6240.2 4942.0 2862.3 4444.8 True False 5939.938216019979 5759.107543632549 6878.730038953165 5465.509473457924 6051.328279700207 6468.3728864881205 5769.496689986161 4810.9221061216185 4857.114045879298 5015.333376018363 1.1843556092248555 1.14830004545075 1.3715399402649757 1.08975995486006 1.20656551140461 1.2897194267120313 1.1503715221751665 0.9592427353136342 0.9684528787466817 1.0 12.292129886584899 -7.665431537901855 4.050804411293098 0.9720475067337115 1.2134814392984137 0.6832922733261355 0.07266611392153073 0.12450753436577305 3.766867189440149 0.03688207302881346 0.01982108528344169 2.1605705998622877e-08 7.665431537901855 0.24143393256470214 SHS(ph)APSEVGFSDAR ddPTM_A459_Selumetinib_30min_R2 4 SHSAPSEVGFSDAR 14 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 S(0.064)HS(0.935)APSEVGFSDAR;S(0.108)HS(0.892)APSEVGFSDAR;S(0.006)HS(0.993)APSEVGFSDAR;S(0.046)HS(0.954)APSEVGFSDAR 127.2 0.00081735 37190500.0 188087.0 184857.0 207588.0 199537.0 232848.0 180258.0 179887.0 159333.0 129281.0 214441.0 True False 177633.87751191735 199034.93749106012 194232.01408472462 172359.71637947543 203595.55255246855 205086.90328079666 188252.10193932822 159796.6326510021 155140.8124129504 208249.5311453696 0.8529857259938759 0.9557521517401295 0.9326888421618583 0.8276595650972145 0.9776519132249459 0.9848132773832501 0.9039737131889047 0.7673324966069445 0.7449755663778835 1.0 17.667953721936343 -7.631755066008059 6.562637624732873 0.8179760352762898 0.9239111684110853 0.1726711910369676 0.07940988052921849 0.2881255359253186 15.614836474770962 0.03688464970705185 0.02104366756210891 2.334774460306312e-08 7.631755066008059 0.10593513313479552 SHS(ph)DLVR ddPTM_A459_Selumetinib_30min_R2 1 SHSDLVR 7 0 O60269 O60269 GPRIN2 G protein-regulated inducer of neurite outgrowth 2 1 S(0.116)HS(0.884)DLVR 68.846 0.04719 3601200.0 3655.8 825.79 3442.4 4514.6 3557.3 2493.0 4286.1 3724.8 2555.7 2964.6 True False 3452.6252713269237 889.1254376666438 3220.9197318017323 3899.7036918806075 3110.400171334505 2836.38812079922 4485.412142746027 3735.6385513261644 3066.9114122243577 2879.004295044157 1.1992428345001718 0.3088308826760562 1.1187616973500663 1.354532085482976 1.0803735780070447 0.985197599629047 1.557973411316926 1.297545320705702 1.0652680919940478 1.0 11.491354225850438 -5.497049968816277 24.06345067325816 1.2083482601958395 0.7439765057610642 0.3039200137681638 0.26042991085983336 474.0088796601469 441610.05834903044 0.06489300355031961 0.13416637517912502 3.183831177150029e-06 5.497049968816277 -0.4643717544347753 SHS(ph)DNDRPNCSWNTQYSSAYYTSR ddPTM_A459_Selumetinib_30min_R2 1 SHSDNDRPNCSWNTQYSSAYYTSR 24 1 O75494-6;O75494-3 O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.023)HS(0.917)DNDRPNCS(0.058)WNT(0.002)QYSSAYYTSR 90.545 2.9111e-05 20390000.0 0.0 0.0 3317.4 3436.3 0.0 997.14 0.0 2931.0 1410.2 805.2 True False 0.0 0.0 3103.962095712019 2968.2700120518625 0.0 1134.4869838643135 0.0 2939.5287247468277 1692.2794042801554 781.9517838391536 0.0 0.0 3.969505741738291 3.795975753746003 0.0 1.4508400739164704 0.0 3.759219923144884 2.164173596448058 1.0 9.61093584160311 -5.185825550605404 23.995075646072827 2.0151849824216 6.977768888349496e-05 0.2501074169062689 1.3973355975907187 127.74500237866035 40536.27069961143 0.372992751121382 0.9868477507396589 6.5189019571300295e-06 5.185825550605404 -2.0151152047327168 SHS(ph)DTSIASR ddPTM_A459_Selumetinib_30min_R2 2 SHSDTSIASR 10 0 E9PEM3;H0Y6E6;Q92622-3;Q92622-2;Q92622;H7C357;H7C3H3 E9PEM3 KIAA0226 Run domain Beclin-1 interacting and cysteine-rich containing protein 1 S(0.163)HS(0.503)DT(0.332)S(0.002)IASR;SHS(1)DTSIASR 111.5 0.008478399999999999 12511800.0 21456.2 16268.9 21065.7 24305.7 27286.9 13224.2 15705.7 18199.4 18583.9 22422.3 True False 20263.750299973955 17516.67231724151 19710.355796599975 20995.221730328823 23858.87567401891 15045.713512664684 16436.046170254143 18252.357240927144 22301.19927755068 21774.909938868183 0.9306008776552132 0.8044429284170896 0.9051865588393098 0.9641932751626395 1.0957049072074851 0.690965590898179 0.7548158048137699 0.8382288281407178 1.0241695299847404 1.0 14.410379131392329 -6.765416059733419 24.999937802142014 0.844849038409513 0.9319004531562116 0.09298091672169395 0.11527927556685877 246.60690071481088 1550315.0430402763 0.04175728500951023 0.038178174790675035 1.7162633967798615e-07 6.765416059733419 0.08705141474669864 SHS(ph)GPAGSFNKPAIR ddPTM_A459_Selumetinib_30min_R1 1 SHSGPAGSFNKPAIR 15 1 Q9UJM3 Q9UJM3 ERRFI1 ERBB receptor feedback inhibitor 1 1 S(0.256)HS(0.744)GPAGSFNKPAIR 83.964 0.012366 115010000.0 2009.8 2588.6 2224.0 2870.7 2515.7 2006.1 2345.7 1847.9 986.19 1615.1 True False 2056.6244296099644 2285.525508592509 1921.9930155575435 2369.386134712946 2288.15537918291 1985.9204553930626 2168.7619604660954 1798.8876891748555 1673.4924015322317 1822.4138174062402 1.12851670129294 1.2541199406869044 1.0546413757403519 1.3001361776795497 1.255563010622658 1.089719819080133 1.1900491204312733 0.9870906772069648 0.9182834247350244 1.0 10.83163487526889 -7.7980019456364325 4.720729780437161 0.9580081208709138 1.1842185934870837 0.6315112956242268 0.07476345887880666 0.12390343407109271 6.291097664899104 0.04124533328603778 0.0198349988555645 1.5922015939824867e-08 7.7980019456364325 0.2262104726161699 SHS(ph)GTSPDNTAPPPPPPRPQPSHSR ddPTM_A459_Selumetinib_30min_R2 1 SHSGTSPDNTAPPPPPPRPQPSHSR 25 1 E9PMG1;H0YDT0;Q96D71-4;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 S(0.253)HS(0.407)GT(0.17)S(0.17)PDNTAPPPPPPRPQPSHSR 66.633 0.00084012 3429900.0 7352.1 5109.6 9056.4 8471.7 7241.5 4879.8 5117.2 7008.0 3841.1 5796.0 True False 6943.499714788196 5501.489890046481 8473.721083862765 7317.839845502359 6331.758030168615 5551.948155586056 5355.159939539433 7028.392119763146 4609.4273293011665 5628.654420183477 1.2335985115536476 0.9774076500982183 1.5054612437170283 1.3001046607625664 1.124915043187572 0.9863721843852477 0.9514103264781482 1.2486806961465653 0.8189217147125748 1.0 12.458574359126063 -6.511824704636898 3.847650040949392 1.0148906211407431 1.250715022812061 0.3691343600914876 0.15521494478249653 0.2700614500277111 8.897082043856 0.052079682711870884 0.05569844874437683 3.077338677968681e-07 6.511824704636898 0.2358244016713178 SHS(ph)LSRPGPTEGDAEGEAEGPVGSTLGSYATLTR ddPTM_A459_Selumetinib_30min_R2 1 SHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTR 34 1 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 S(0.203)HS(0.35)LS(0.35)RPGPT(0.097)EGDAEGEAEGPVGSTLGSYATLTR 60.562 0.00021028 3987000.0 4783.6 3897.1 5030.2 5435.6 6376.7 3496.5 4000.6 4403.4 3535.4 4771.1 True False 4517.746662268034 4195.995038848473 4706.56240846766 4695.26190306699 5575.6019375787055 3978.1111369332025 4186.635827038513 4416.213164977889 4242.5787873295 4633.345946193473 0.9750505821780027 0.9056079747931826 1.015802071143498 1.013363119782667 1.2033640488596247 0.858582800233473 0.9035880065200064 0.9531369373802169 0.9156619938588857 1.0 12.177838689076214 SHS(ph)PSASQSGSQLR ddPTM_A459_Selumetinib_30min_R1 6 SHSPSASQSGSQLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.018)HS(0.917)PS(0.038)AS(0.018)QS(0.009)GSQLR;S(0.396)HS(0.604)PSASQSGSQLR;S(0.014)HS(0.986)PSASQSGSQLR;S(0.124)HS(0.862)PS(0.014)ASQSGSQLR;SHS(0.989)PS(0.01)ASQSGSQLR;S(0.181)HS(0.807)PS(0.012)ASQSGSQLR 225.21 1.1465999999999995e-09 36619000.0 4365.9 5045.38 5549.530000000001 5184.5599999999995 5112.18 4441.79 5062.339999999999 4645.719999999999 2347.46 3750.3 True False 4467.61697543743 4454.664564066476 4795.934307386268 4279.173922244522 4649.784221628683 4397.109625422638 4680.4836180866805 4522.500414174689 3983.4681683051494 4231.687536015493 1.0557530388087408 1.052692224119396 1.1333384770422024 1.0112216192298882 1.098801407725596 1.0390912816693703 1.1060560540568098 1.0687226728542962 0.9413426994319 1.0 12.047017388748367 -8.249670005075586 24.220652367708578 0.9706713541779732 1.0712743863472052 0.5561953798301975 0.03574157296009762 288.935390233517 594615.8963600327 0.02284014501874895 0.008461967751135651 5.627687777841486e-09 8.249670005075586 0.10060303216923194 SHS(ph)PSASQSGSQLR ddPTM_A459_Selumetinib_30min_R2 2 SHSPSASQSGSQLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.331)HS(0.668)PS(0.001)ASQSGSQLR;S(0.062)HS(0.936)PS(0.001)AS(0.001)QSGSQLR 184.0 7.7708e-05 19670900.0 6800.299999999999 5120.9 8301.8 8763.6 13252.1 7294.6 6203.4 7055.6 6262.1 9150.6 True False 6422.3665497577795 5513.65656371126 7767.671226316404 7569.982561946777 11587.252722722844 8299.364936214199 6491.870391803904 7076.130627882541 7514.694977693069 8886.398401885945 0.7227187280276306 0.6204602038257824 0.8741079203322557 0.8518617126529251 1.303931266491912 0.9339402264986048 0.7305401016486213 0.7962877993834697 0.8456401162588252 1.0 13.117383107479801 -5.3802613222008695 3.8329274691314694 0.9198373347321986 0.6718740558360501 0.3057868244165206 0.14881944908863742 0.3089256465936927 7.897528396314709 0.04378571804290212 0.09966717252191146 4.166186216918515e-06 5.3802613222008695 -0.24796327889614855 SHS(ph)PSIDGTPK ddPTM_A459_Selumetinib_30min_R2 1 SHSPSIDGTPK 11 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 S(0.371)HS(0.624)PS(0.005)IDGTPK 103.97 0.0084388 4293200.0 65275.0 59681.0 62240.0 59741.0 65659.0 46515.0 55039.0 63618.0 49163.0 57784.0 True False 61647.276816528494 64258.34079533898 58235.5461617882 51604.172741026756 57410.32942109241 52922.019028871124 57598.422557709484 63803.117847473135 58996.973728992525 56115.625779137634 1.0985759485096465 1.1451060182105035 1.0377777197209606 0.9196043352369043 1.023072069926664 0.9430888151753658 1.0264239551458965 1.1369937866966373 1.051346624221842 1.0 15.776114934610288 -5.362120974098744 5.253558616450524 1.0154435565890123 1.1210501116410472 0.3564667798719653 0.05669339021091033 0.2492300619178262 10.285041523858885 0.01642199680552485 0.035327140113984745 4.3438920683280115e-06 5.362120974098744 0.10560655505203487 SHS(ph)PSSPDPDTPSPVGDSR ddPTM_A459_Selumetinib_30min_R1 1 SHSPSSPDPDTPSPVGDSR 19 0 E9PNJ4;G0XQ39;Q13586;H0YDB2 E9PNJ4 STIM1 Stromal interaction molecule 1 1 S(0.2)HS(0.773)PS(0.022)S(0.005)PDPDTPSPVGDSR 106.02 0.0013745 0.0 1058.4 1204.3 1100.8 991.4 1259.2 1096.3 1028.3 1206.0 415.3 725.06 True False 1083.0586607121033 1063.299996136119 951.3174062615763 818.270600882856 1145.305582329816 1085.2722173607574 950.7345031109198 1174.012962359909 704.7337676881089 818.1285136824769 1.3238246101913131 1.2996735578254097 1.1627970304807043 1.0001736734486122 1.3999091379601023 1.3265302445893745 1.162084546878302 1.4349982218264965 0.8613973916103143 1.0 9.676183672904596 -8.273626787074395 24.999258393050887 0.9306986451520186 1.2560380437192353 0.530278588996296 0.12521460421683941 691.2295510507626 1417860.1957953845 0.11858862489261258 0.03155226685576579 5.325657254386561e-09 8.273626787074395 0.3253393985672167 SHS(ph)QASLAGPGPVDPSNR ddPTM_A459_Selumetinib_30min_R2 1 SHSQASLAGPGPVDPSNR 18 0 A6PVU7;Q9P2M7-2;Q9P2M7;A2A3M4 A6PVU7 CGN Cingulin 1 S(0.29)HS(0.586)QAS(0.123)LAGPGPVDPSNR 57.316 0.040132 12585000.0 21591.0 20339.0 23410.0 20016.0 27963.0 18137.0 17504.0 21554.0 14569.0 23592.0 True False 20391.058655621095 21898.935899807297 21903.82608688082 17289.786270474087 24450.037947608213 20635.207118706567 18317.970683518004 21616.71857154322 17483.207091871776 22910.837660622587 0.8900180324121323 0.9558330526450165 0.956046496917372 0.7546553524837053 1.0671821916677926 0.9006744940702364 0.7995329963426674 0.9435149815013705 0.763097681143304 1.0 14.48374258663087 -7.004537861118096 24.996485473188425 0.86872566915591 0.9252798373189198 0.051274029709512337 0.09546924279173585 563.9821870317187 3106667.1427760804 0.03263150993067024 0.02807828045824915 9.896055878310216e-08 7.004537861118096 0.056554168163009844 SHS(ph)SPASLQLGTGAGAAGSPAQQHAHLR ddPTM_A459_Selumetinib_30min_R2 1 SHSSPASLQLGTGAGAAGSPAQQHAHLR 28 0 Q9GZV5;C9JR84;C9J038 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 S(0.067)HS(0.421)S(0.421)PAS(0.091)LQLGTGAGAAGSPAQQHAHLR 172.06 2.0692e-22 22194000.0 20589.0 20987.0 39731.0 56454.0 61839.0 36194.0 25676.0 26674.0 33336.0 46512.0 True False 19444.745804297298 22596.6354161589 37174.750715842005 48764.86781141805 54070.23197232571 41179.394963580795 26869.984876028775 26751.61692388157 40004.131485663886 45169.07770731084 0.4304879973484619 0.500267806276273 0.8230132781707227 1.0796073395035297 1.1970630067475159 0.9116722557502144 0.5948756591875183 0.5922551064077115 0.8856530510736778 1.0 15.46304783570537 -5.263328924819909 3.812364370436559 0.8829118054822134 0.44936138661531666 0.47258457065211135 0.17903779615079132 0.21940947089479754 7.294142268545253 0.055214818086777216 0.14617908163835375 5.453446729179226e-06 5.263328924819909 -0.4335504188668967 SHS(ph)SPSLNPDTSPITAK ddPTM_A459_Selumetinib_30min_R2 2 SHSSPSLNPDTSPITAK 17 0 A0A087X1Z0;A0A087WXD8;B4DKF8;E5RJ29;Q9NYI0-3;Q9NYI0-2;Q9NYI0 A0A087X1Z0 PSD3 PH and SEC7 domain-containing protein 3 1 S(0.131)HS(0.607)S(0.131)PS(0.131)LNPDTSPITAK;S(0.062)HS(0.689)S(0.187)PS(0.061)LNPDTSPITAK 98.684 0.0033675 10504200.0 53236.0 43859.0 81162.0 108961.0 101117.0 76146.0 62549.0 64561.0 64873.0 88858.0 True False 50277.35624059305 47222.844271087495 75940.12528250394 94120.32383179109 88413.77846255062 86634.42031543427 65457.652438492136 64748.86182135109 77849.4127030679 86292.43865918965 0.5826391862578194 0.5472419716586435 0.8800322074849226 1.0907134540897323 1.0245831481451018 1.0039630547190266 0.7585560618702166 0.7503422411907432 0.9021579864086664 1.0 16.396946528909517 -5.297275773523165 5.120532844835752 0.9255888336651454 0.5625365417615746 0.6573515039603735 0.10463501575798378 0.12054637149922545 8.428496059661006 0.031622222443595874 0.07164613931118181 5.043409433970404e-06 5.297275773523165 -0.3630522919035708 SHS(ph)SPSQIPK ddPTM_A459_Selumetinib_30min_R2 1 SHSSPSQIPK 10 0 Q9H792;H0YN99 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 S(0.236)HS(0.379)S(0.379)PS(0.006)QIPK 146.16 0.00057772 26083000.0 219250.0 190520.0 208950.0 219190.0 218020.0 165940.0 185480.0 181070.0 148890.0 180460.0 True False 207064.96272729046 205132.27138164578 195506.38448755868 189335.94387616016 190630.3784764707 188796.72874665976 194105.18752164755 181596.8837222476 178672.1603341879 175249.6509086108 1.1815427971110237 1.1705145791623754 1.1155878683576457 1.0803784366731497 1.0877646687917264 1.0773015967096762 1.1075924346512367 1.0362182337067636 1.0195293366225413 1.0 17.419052044875748 -1.5228787453194235 0.1682008284377364 0.987569389640669 1.7938647556993896 0.8727158841599509 0.02017836106521944 22.08104419519282 0.23718393385445244 0.05919793458461376 4.46640948629787 0.02999999999730004 1.5228787453194235 0.8062953660587207 SHS(ph)SSEAYEPR ddPTM_A459_Selumetinib_30min_R1 7 SHSSSEAYEPR 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 SHS(0.461)S(0.461)S(0.079)EAYEPR;S(0.035)HS(0.909)S(0.053)S(0.003)EAYEPR;S(0.227)HS(0.379)S(0.379)S(0.015)EAYEPR;S(0.207)HS(0.388)S(0.388)S(0.017)EAYEPR;S(0.007)HS(0.955)S(0.032)S(0.005)EAYEPR;S(0.037)HS(0.832)S(0.053)S(0.078)EAYEPR;S(0.004)HS(0.747)S(0.245)S(0.004)EAYEPR 174.23 0.00014431 145972800.0 5689.320000000001 6381.200000000001 6002.42 6994.83 8942.0 5576.469999999999 6950.03 5786.31 2902.13 4279.59 True False 5821.870086510382 5634.086137460602 5187.3243329329625 5773.314249721031 8133.197678838321 5520.375774829649 6425.783641598746 5632.838262216228 4924.702646811198 4828.917063236689 1.205626439690423 1.1667390563308269 1.0742210448021328 1.1955712169244297 1.6842694898940478 1.143191258524017 1.3306883422205065 1.1664806391271283 1.0198358311646603 1.0 12.237483970064424 -8.143125632956039 2.9612975906910646 1.003227564815536 1.2564111776325555 0.27646746802506406 0.15807711912161077 0.38362663512041134 6.019349136719605 0.13882714960159276 0.04402220473969182 7.192408854919988e-09 8.143125632956039 0.2531836128170195 SHS(ph)SSEAYEPR ddPTM_A459_Selumetinib_30min_R2 3 SHSSSEAYEPR 11 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 S(0.161)HS(0.817)S(0.021)S(0.001)EAYEPR;S(0.017)HS(0.887)S(0.096)SEAYEPR;S(0.008)HS(0.492)S(0.492)S(0.008)EAYEPR 158.34 0.00054921 230339000.0 31560.4 26450.3 40690.5 50802.3 61343.7 34480.8 31761.4 26996.0 30647.4 42183.4 True False 29806.399314291346 28478.95295888064 38072.517530466626 43882.93910114434 53637.15598636395 39230.21721446197 33238.36803402014 27074.5538905716 36777.736359903305 40965.45563636434 0.7275983838400838 0.6951943415857031 0.9293810343139525 1.071218137805605 1.3093264838180185 0.9576414226340978 0.8113755240284696 0.6609118211915597 0.897774375717094 1.0 15.32212024077116 -12.586529337029233 11.256547205228635 0.9302314536499097 0.9059953205719967 0.0 0.18637988868907027 0.0 0.0 0.0 0.04800935490155139 2.591019389476133e-13 12.586529337029233 -0.024236133077912947 SHS(ph)TEPNLSSFLNDPNPMK ddPTM_A459_Selumetinib_30min_R2 2 SHSTEPNLSSFLNDPNPMK 19 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(0.034)HS(0.786)T(0.18)EPNLSSFLNDPNPMK;S(0.048)HS(0.743)T(0.209)EPNLSSFLNDPNPMK 115.96 0.0003113 5356900.0 55871.0 43184.0 63341.0 72585.0 79910.0 31186.0 38561.0 55772.0 33538.0 44529.0 True False 52765.91348933378 46496.07394155458 59265.70902046636 62698.7977838909 69870.99139553605 35481.58842167846 40354.1629071719 55934.28728644834 40246.5371300155 43243.33206976362 1.2202092429928286 1.0752195012757892 1.3705167059017134 1.4499067204798222 1.615763357060796 0.8205100468307278 0.933188100354277 1.293477736549317 0.9306992593698966 1.0 15.400190072263866 -6.770971994245337 24.999999832918384 1.0100182287815798 1.338360547420366 0.5032960716499697 0.17383600068297697 200.5313476750172 525905.3279097072 0.0660968308192201 0.05904163750099976 1.6944470644161938e-07 6.770971994245337 0.32834231863878616 SHS(ph)VPENMVEPPLSGR ddPTM_A459_Selumetinib_30min_R1 1 SHSVPENMVEPPLSGR 16 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.022)HS(0.978)VPENMVEPPLSGR 129.05 0.00090241 6863800.0 1429.7 1481.5 1602.4 1664.3 1564.1 1405.7 1376.4 1290.2 570.34 930.42 True False 1463.0092282880712 1308.0452912693352 1384.8028813531519 1373.6612477802482 1422.6274311642835 1391.559934273481 1272.5770398540024 1255.979704839763 967.8253240145342 1049.8484700582721 1.39354323029767 1.2459372267282838 1.3190502447236867 1.3084376335796373 1.3550788249330117 1.3254864620569882 1.212153064130643 1.1963437969005655 0.9218714429910202 1.0 10.035965396104562 -7.9904520041572455 1.6579593141881306 0.9575853402632184 1.317642616986264 0.8732307808016141 0.052217709930157195 0.11908760331562898 0.5893473774295113 0.04309155568542969 0.014407811622746828 1.0222285254445252e-08 7.9904520041572455 0.36005727672304566 SHS(ph)VPENMVEPPLSGR ddPTM_A459_Selumetinib_30min_R2 2 SHSVPENMVEPPLSGR 16 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.059)HS(0.941)VPENMVEPPLSGR;S(0.171)HS(0.829)VPENMVEPPLSGR 143.33 0.00025935 17109200.0 190216.0 164535.0 193791.0 213658.0 251930.0 124951.0 154719.0 185100.0 125914.0 171045.0 True False 179644.55621497968 177154.30543658987 181322.6980436869 184557.41181939162 220280.30111722424 142161.86605775513 161913.74006988254 185638.61035504518 151100.31833110974 166106.48642171873 1.0815023548140672 1.0665104611677982 1.0916051621448217 1.1110788976104693 1.3261390681515384 0.8558477704285918 0.9747586837687274 1.1175879663346644 0.909659349168878 1.0 17.341748885760772 -6.780769043264944 24.999493227657094 0.9791193021018222 1.1277613461951181 0.43469282986220203 0.09299470244360197 270.1919019997672 349442.95029190206 0.03354711423062973 0.029629279062817898 1.6566507320295872e-07 6.780769043264944 0.14864204409329596 SHS(ph)WVNSAYAPGGSK ddPTM_A459_Selumetinib_30min_R2 1 SHSWVNSAYAPGGSK 15 0 K7ESB7;K7EKT0 K7ESB7 DOCK6 1 S(0.191)HS(0.809)WVNSAYAPGGSK 123.54 0.00094587 11092000.0 66315.0 67980.0 73231.0 82914.0 84870.0 58817.0 64439.0 69520.0 54698.0 68748.0 True False 62629.477779978406 73193.84740984814 68519.39718788404 71620.97016537197 74207.8718525734 66918.50786243382 67435.54118345615 69722.29169034443 65639.12838981413 66763.06661124447 0.9380856955637524 1.0963224298256031 1.026306918866782 1.0727633375862533 1.1115108340466051 1.0023282521172143 1.010072553678929 1.0443242833096817 0.9831652696845856 1.0 16.026762602722485 SHSESAS(ph)PSALSSSPNNLSPTGWSQPK ddPTM_A459_Selumetinib_30min_R2 1 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 S(0.006)HS(0.02)ES(0.017)AS(0.799)PS(0.063)ALS(0.028)S(0.033)S(0.033)PNNLSPTGWSQPK 96.783 1.4800999999999996e-06 2020600.0 5324.4 4913.9 7178.6 7933.3 8242.1 6335.7 5232.8 5708.6 4622.8 6542.5 True False 5028.491163261961 5290.78032932116 6716.736691468715 6852.770854294164 7206.653712691122 7208.385165241725 5476.135568596493 5725.211080890395 5547.489171824069 6353.601025543544 0.7914395542064713 0.8327215240696577 1.0571543073707725 1.078564868449214 1.1342628666354762 1.1345353817876935 0.8618947816491224 0.9010970405401887 0.8731252008933763 1.0 12.63335878350453 -10.752028418595701 20.676232750141814 0.9999999996708117 0.9704302070878487 0.004764475922103939 0.12249181574376254 0.0 0.0 0.13262733715659525 0.03216685411417931 1.7699931328415903e-11 10.752028418595701 -0.029569792582962995 SHSESASPSALSS(ph)SPNNLS(ph)PTGWSQPK ddPTM_A459_Selumetinib_30min_R1 1 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 2 S(0.001)HS(0.001)ES(0.001)AS(0.01)PS(0.031)ALS(0.168)S(0.72)S(0.379)PNNLS(0.501)PT(0.166)GWS(0.022)QPK 56.483 0.033902 4297000.0 352.33 386.58 486.13 816.08 547.5 670.48 415.95 419.67 163.37 336.98 True False 360.53860348516207 341.3190338838337 420.11621612094854 673.5669477188633 497.97872166897577 663.7355799471316 384.57455661673384 408.5389883197208 277.2269579272968 380.23466546316337 0.9482002464083343 0.8976536462504633 1.104886677308092 1.7714506563950245 1.3096615508803977 1.745594603108152 1.0114137177584375 1.074439090981039 0.7290943806756992 1.0 8.570746256248245 -7.495752132223199 24.617913705041207 0.94964513603469 1.2988751480669012 0.2601246134355608 0.2848397997537344 925.7813526515333 840166.701876078 0.13063941765221437 0.08778425078196239 3.193359902623001e-08 7.495752132223199 0.34923001203221116 SHSESASPSALSS(ph)SPNNLS(ph)PTGWSQPK ddPTM_A459_Selumetinib_30min_R2 1 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 2 SHSESASPSALS(0.023)S(0.758)S(0.247)PNNLS(0.934)PT(0.036)GWSQPK 146.37 4.4958999999999996e-13 4996800.0 22618.0 18175.0 27173.0 36576.0 35161.0 26914.0 23770.0 29847.0 23763.0 32700.0 True False 21360.98210702783 19568.96405816402 25424.718763725436 31594.285702880676 30743.760836671783 30621.159199033355 24875.35209936144 29933.849828563147 28516.263993695444 31755.866035196603 0.6726625588907698 0.6162314715799205 0.800630621616364 0.9949117957565119 0.9681285593848061 0.9642678037844852 0.783330930789003 0.942624263352981 0.8979841381774772 1.0 14.95473549484194 -5.484787367264195 3.64241870281782 0.9291652683827791 0.6481395844398061 0.7850277799641555 0.06087604096587315 0.10373093439112599 2.8402203743843537 0.017267119000338036 0.03681774632804993 3.2750100174951456e-06 5.484787367264195 -0.281025683942973 SHSESASPSALSS(ph)SPNNLSPTGWSQPK ddPTM_A459_Selumetinib_30min_R1 1 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 SHSESASPSALS(0.001)S(0.498)S(0.498)PNNLS(0.003)PTGWSQPK 123.72 5.0703e-12 6425300.0 1465.5 1485.6 1423.9 1415.0 2055.7 1161.9 1529.2 1126.8 451.39 739.2 True False 1499.6432986333969 1311.6652613632968 1230.5422009228366 1167.8968128396623 1869.7622979633122 1150.2123409207923 1413.8512128340162 1096.913603637766 765.9758617787992 834.0835204177404 1.797953396660228 1.5725826362165334 1.4753225196279323 1.400215666957112 2.2416967272376573 1.3790133874659491 1.6950954889096794 1.3151124279357427 0.9183443180788055 1.0 9.704048044019563 -8.01686922079081 2.678901146329341 0.9581125616316605 1.6458504441533621 0.5802152992395893 0.23590811602746348 0.20597133766287545 2.8050055288059377 0.18319329802756312 0.06377690194570008 9.619018925403274e-09 8.01686922079081 0.6877378825217016 SHSESASPSALSS(ph)SPNNLSPTGWSQPK ddPTM_A459_Selumetinib_30min_R2 1 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 SHSESASPSALS(0.083)S(0.458)S(0.458)PNNLSPTGWSQPK 135.91 2.9348e-12 24484000.0 38313.0 26107.0 51918.0 60432.0 72263.0 44907.0 36275.0 44807.0 40682.0 50139.0 True False 36183.716839090885 28109.322952764134 48577.652404044326 52201.05734898528 63184.67590058342 51092.53162484179 37961.85937754887 44937.38095180183 48819.53675005336 48691.35679323315 0.7431240208142956 0.5772959474538736 0.9976647931650032 1.0720805659751074 1.2976569161729432 1.0493141902330876 0.7796426692062234 0.9229026240247833 1.0026324991797728 1.0 15.571378081668023 -5.2730570532541154 22.107290828897618 1.0174029394168178 0.660210026141986 0.5534750059479436 0.1275423959681564 110.82026507170389 210882.30637908756 0.03746061631789476 0.07938474702139166 5.33264835899067e-06 5.2730570532541154 -0.3571929132748318 SHSESASPSALSSS(ph)PNNLSPTGWSQPK ddPTM_A459_Selumetinib_30min_R1 2 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 SHSESASPSALS(0.012)S(0.049)S(0.934)PNNLS(0.002)PT(0.002)GWSQPK;SHSESASPSALS(0.013)S(0.08)S(0.832)PNNLS(0.064)PT(0.009)GWSQPK 110.91 6.361599999999999e-10 16958600.0 2141.27 2313.1400000000003 2419.7 2469.96 3172.9 2456.34 2458.05 2173.2 657.84 1587.3700000000001 True False 2191.1574248138754 2042.3164934503889 2091.1180304606955 2038.6278528914868 2885.911755220993 2431.631449778275 2272.637309512591 2115.559676451539 1116.3064332673864 1791.124401793168 1.2233418419291355 1.1402426829793297 1.1674889965025275 1.138183283556705 1.6112290985102926 1.3576005370391186 1.2688327551326757 1.181134975512346 0.6232433839602689 1.0 10.806649827244083 -8.116719334132696 5.31000521567892 0.8180042278251743 1.2713351988150856 0.5749633641058431 0.15597085278574277 0.16586907342849472 6.4394985274484435 0.11544232351216595 0.04201691307207511 7.643295773735587e-09 8.116719334132696 0.45333097098991126 SHSESASPSALSSSPNNLS(ph)PTGWSQPK ddPTM_A459_Selumetinib_30min_R2 1 SHSESASPSALSSSPNNLSPTGWSQPK 27 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 SHSESASPSALSSSPNNLS(0.821)PT(0.179)GWSQPK 224.08 3.0730999999999994e-45 7504500.0 14235.0 12173.0 18649.0 25829.0 23194.0 19147.0 16995.0 18505.0 19898.0 27089.0 True False 13443.875687219968 13106.629957635787 17449.143643495954 22311.04564248975 20280.162363009156 21784.325450839402 17785.30117495363 18558.846486332346 23878.155996572485 26306.87018432542 0.5110404845966934 0.4982208018590212 0.6632922700889284 0.8481071859237543 0.7709074557676879 0.8280850324725929 0.676070587277644 0.7054752753290422 0.9076775697475388 1.0 14.683151996044653 -5.473537352462078 2.982657738608254 0.7992781986386981 0.5042662832193183 0.6584288242427442 0.09019192722790279 0.15974697642918895 2.796112631037483 0.02448325881981597 0.05565117367019646 3.3609546116686307e-06 5.473537352462078 -0.29501191541937977 SHSGTSPDNTAPPPPPPRPQPS(ph)HSR ddPTM_A459_Selumetinib_30min_R2 1 SHSGTSPDNTAPPPPPPRPQPSHSR 25 1 E9PMG1;H0YDT0;Q96D71-4;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 SHSGTSPDNTAPPPPPPRPQPS(0.5)HS(0.5)R 55.302 0.0056332 3528600.0 1001.1 951.22 1028.6 1144.9 2490.1 2465.6 1082.0 777.79 1979.8 1125.9 True False 945.4628697208226 1024.1755153456268 962.4209958550018 988.9626449373385 2177.271376223553 2805.214019511654 1132.3151439423261 780.0532401299342 2375.815320233903 1093.3923415604852 0.8647059557518592 0.9366953438542724 0.8802155999020794 0.9044901883306544 1.9912992742533389 2.5656060618716827 1.0355982028612807 0.7134248251790801 2.172884544666875 1.0 10.094595460289902 -6.235136158080534 22.6130838580613 1.5875532982156821 0.8982303986345936 0.28007816886215064 0.5365772891765387 332.2522993640235 285638.3565593402 0.16761395990768654 0.21626847908692823 5.819207479558321e-07 6.235136158080534 -0.6893228995810885 SHSLS(ph)RPGPTEGDAEGEAEGPVGSTLGSYATLTR ddPTM_A459_Selumetinib_30min_R2 2 SHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTR 34 1 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 S(0.044)HS(0.243)LS(0.522)RPGPT(0.192)EGDAEGEAEGPVGSTLGSYATLTR;S(0.021)HS(0.26)LS(0.714)RPGPT(0.004)EGDAEGEAEGPVGSTLGSYATLTR 101.49 1.0973e-11 9515400.0 10138.7 7900.299999999999 11562.9 14007.8 13662.0 8823.3 9054.3 10389.4 9244.599999999999 12666.5 True False 9575.231642431832 8506.227606531667 10818.95560273362 12099.913475197187 11945.65742017035 10038.629485057258 9475.342890755082 10419.631433942244 11093.778315705804 12300.785233480676 0.7784244225620375 0.6915190733823351 0.8795337368614677 0.9836700052500105 0.9711296631418515 0.8160966389148712 0.7703039042552168 0.8470704297463673 0.901875620550662 1.0 13.586462793999276 -1.5228799469253875 0.028921989737508032 1.462375609642214 1.4094220788388738e-10 0.2618141478030692 0.08347856956628902 2684.120544752449 5.978631774020205 98.04556099697068 229.9162224394398 0.029999916993415462 1.5228799469253875 -1.4623756095012719 SHSLSRPGPT(ph)EGDAEGEAEGPVGSTLGSYATLTR ddPTM_A459_Selumetinib_30min_R1 1 SHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTR 34 1 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 S(0.005)HS(0.034)LS(0.292)RPGPT(0.669)EGDAEGEAEGPVGSTLGSYATLTR 69.612 0.00010884 18923000.0 294.46 449.48 532.5 656.21 586.41 365.36 507.43 499.34 223.48 380.73 True False 301.3203450805802 396.8546726424171 460.18942481312615 541.6152420872901 533.3693190390944 361.68481012033766 469.1541465657631 486.09588111508856 379.22923766659903 429.600404124251 0.7013967915016927 0.9237763019599883 1.0712034262426533 1.260741928749773 1.2415475263026776 0.8419098460990496 1.0920710084575995 1.1315070387468669 0.8827487917281303 1.0 8.746851540239062 -4.8918743731515475 2.3976253406807815 1.0754448799458667 0.6614209759647004 0.4347359226734471 0.12775291420716942 0.41358365868320635 3.5560901164023373 0.03512776779824953 0.3274222501456442 1.2827015716011948e-05 4.8918743731515475 -0.4140239039811663 SHSPSASQSGS(ph)QLR ddPTM_A459_Selumetinib_30min_R2 1 SHSPSASQSGSQLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.292)HS(0.11)PS(0.059)AS(0.015)QS(0.015)GS(0.509)QLR 112.96 0.0034460000000000003 14170000.0 2747.7 1238.4 2375.9 3008.7 4457.9 2134.3 1170.8 980.0 552.92 3122.6 True False 2594.9938339145974 1333.3812979163863 2223.0371806843286 2598.9098697030054 3897.8587478683503 2428.280451753619 1225.244519896187 982.8516377522666 663.5194498756084 3032.4424245108553 0.8557438099861632 0.4397053962636952 0.7330847117543916 0.8570351900818759 1.2853859042343039 0.8007672073593649 0.404045435452521 0.3241122172041912 0.21880694073940635 1.0 11.566264538528497 -7.245018457444253 7.764754391143802 0.43011876082670114 0.8291839533972605 0.2624489649985329 0.27432979313238326 0.2312726836000891 83.42501589802663 0.11099588283464933 0.0830393304492651 5.6882875520131113e-08 7.245018457444253 0.39906519257055934 SHSS(ph)LPPNNSYADFER ddPTM_A459_Selumetinib_30min_R1 1 SHSSLPPNNSYADFER 16 0 O43293 O43293 DAPK3 Death-associated protein kinase 3 1 SHS(0.098)S(0.902)LPPNNSYADFER 181.75 9.5169e-07 5501200.0 933.02 948.76 1066.0 1034.0 1241.4 1016.9 1174.3 950.24 528.02 830.62 True False 954.757550659115 837.6787381334422 921.2430551188593 853.4313105838946 1129.1155891869707 1006.6709092713253 1085.7216055656456 925.0365483854723 896.0113749450397 937.2381679239497 1.0186925621840306 0.8937736071813647 0.9829337799584914 0.910581045236673 1.2047264268889555 1.074082281029137 1.1584265800555236 0.9869813031990525 0.9560124689861593 1.0 9.87227189723374 -6.220703927311997 24.99885629419148 1.0680089881278831 0.9496178681959309 0.32831943624110727 0.07820585637877107 607.3522933912353 372724.58959255234 0.023619419864693215 0.030492165322388333 6.015837169253258e-07 6.220703927311997 -0.11839111993195228 SHSS(ph)LPPNNSYADFER ddPTM_A459_Selumetinib_30min_R2 2 SHSSLPPNNSYADFER 16 0 O43293 O43293 DAPK3 Death-associated protein kinase 3 1 S(0.013)HS(0.055)S(0.932)LPPNNSYADFER;S(0.04)HS(0.187)S(0.773)LPPNNSYADFER 83.666 0.012001 16599000.0 89119.0 82128.0 89614.0 99577.0 90965.0 55833.0 77029.0 79678.0 69408.0 81435.0 True False 84166.12275162325 88426.9535168581 83848.33280434608 86014.44082009369 79537.16346258206 63523.48894848892 80611.00113006776 79909.84978859697 83291.53942155525 79083.75995645986 1.0642655685309033 1.1181430114797553 1.060247171486401 1.0876372199228965 1.0057332062407227 0.8032431561607875 1.0193116914831657 1.0104457581757862 1.0532066187471614 1.0 16.271093843706936 -6.348716144565552 4.710687479742134 0.9735689959928701 1.0834550592538699 0.3685388534321953 0.06481022719903398 0.2505868652797461 9.654850507611876 0.02152004632589178 0.024634473136697713 4.480060258215863e-07 6.348716144565552 0.10988606326099981 SHSS(ph)PSQIPK ddPTM_A459_Selumetinib_30min_R1 2 SHSSPSQIPK 10 0 Q9H792;H0YN99 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 SHS(0.024)S(0.893)PS(0.083)QIPK;S(0.001)HS(0.069)S(0.861)PS(0.069)QIPK 170.4 0.00020597 46278000.0 16382.0 19305.8 19558.5 20753.7 19102.1 15278.9 16956.0 16632.6 8557.1 13581.9 True False 16763.66872617694 17045.467960977065 16902.56312715028 17129.455890198253 17374.318427749677 15125.208138131242 15676.99526864609 16191.449417701022 14520.773714143794 15325.269163909239 1.0938580293033358 1.1122459108985092 1.102921126302665 1.1177262667945724 1.1337039657786836 0.9869456762136917 1.0229507293460893 1.0565197416454926 0.9475052972211399 1.0 13.903624792325337 -6.7618287594559225 24.99999996789879 1.0075771664825168 1.1119032961038335 0.7957144381099863 0.027638809004429565 4.751168350219883 305032.49768755154 0.009289872695402978 0.008703714820664133 1.7304985532393204e-07 6.7618287594559225 0.10432612962131671 SHSS(ph)PSQIPK ddPTM_A459_Selumetinib_30min_R2 2 SHSSPSQIPK 10 0 Q9H792;H0YN99 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 SHS(0.341)S(0.611)PS(0.048)QIPK;SHS(0.029)S(0.773)PS(0.198)QIPK 169.65 0.00022878 20838000.0 201071.0 173376.0 209557.0 216401.0 210648.0 169268.0 163109.0 171725.0 139004.0 172342.0 True False 189896.2787709876 186673.38170829372 196074.33076840988 186926.81048745263 184184.5150229866 192583.1305380837 170693.89169435177 172224.6913193958 166808.68409626916 167366.0386617084 1.134616558349803 1.1153599810389887 1.1715299730833006 1.116874199701182 1.100489182248454 1.1506703037128447 1.0198836816552124 1.0290300989169496 0.996669846703095 1.0 17.352647285329645 -7.269682284967231 24.00817513046876 1.0138150624119948 1.1305851791636 0.8924487578357774 0.02043244302239094 113.27882283806404 329932.2225899161 0.00849272723705547 0.0058399848573297795 5.374248142604812e-08 7.269682284967231 0.11677011675160509 SHSTYS(ph)STPGR ddPTM_A459_Selumetinib_30min_R2 1 SHSTYSSTPGR 11 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;A0A0A0MR81 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 SHSTYS(0.45)S(0.1)T(0.45)PGR 86.262 0.0223 849960.0 3297.2 2300.9 3854.2 4152.5 5198.6 2014.2 4473.9 8028.8 5053.3 6233.2 True False 3113.954823737386 2477.3716314404182 3606.2249681356684 3586.92233653795 4545.505391926336 2291.6377669128706 4681.94521486467 8052.162478760611 6064.1012009990845 6053.231320201451 0.5144285190861918 0.40926432518325956 0.5957520500002391 0.5925632355345999 0.7509221358775138 0.3785809009586313 0.7734621340571625 1.3302254701366072 1.0017957154158899 1.0 12.56348976839331 -7.559597899059146 5.4386318618908716 1.1193452387969083 0.5499556669826934 0.7943448698568264 0.1297731448347624 0.07735954034462768 5.860391498608571 0.06059445390093522 0.034943366642826365 2.7567799464429787e-08 7.559597899059146 -0.5693895718142149 SHT(ph)SEGAHLDITPNSGAAGNSAGPK ddPTM_A459_Selumetinib_30min_R1 1 SHTSEGAHLDITPNSGAAGNSAGPK 25 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 S(0.188)HT(0.625)S(0.188)EGAHLDITPNSGAAGNSAGPK 102.06 1.8338e-06 24783000.0 4284.0 4594.0 4121.7 4434.3 6795.8 4283.7 6334.8 3664.8 1028.8 2417.7 True False 4383.808864787089 4056.1323443073443 3561.995778877486 3659.9327471200822 6181.1210898959425 4240.609867288401 5856.96093582326 3567.5975990519046 1745.7984594209643 2728.035345392278 1.6069472384921462 1.4868327681891131 1.3057000104099783 1.3416001934512334 2.2657774945387037 1.554455617465111 2.1469519981534764 1.3077534369478272 0.639947155512359 1.0 11.413646621213255 -8.023371781982885 6.216844450255666 0.8595984927350446 1.6624886923449584 0.549983929475823 0.30720865214863785 0.14015596520602927 19.443938944616885 0.20552920776865882 0.08235994009290594 9.476069079410613e-09 8.023371781982885 0.8028901996099138 SHT(ph)SEGAHLDITPNSGAAGNSAGPK ddPTM_A459_Selumetinib_30min_R2 1 SHTSEGAHLDITPNSGAAGNSAGPK 25 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 S(0.161)HT(0.64)S(0.193)EGAHLDIT(0.005)PNSGAAGNSAGPK 84.57600000000002 8.3286e-05 34827000.0 156790.0 120530.0 210810.0 251900.0 286250.0 202640.0 146700.0 178120.0 144690.0 249180.0 True False 148076.2394800998 129774.26343496617 197246.71411257377 217590.78544826203 250288.71589253112 230551.8206172297 153521.84068053527 178638.29971064662 173632.0429763829 241985.5259526085 0.6119218862251277 0.5362893624488174 0.8151178188698915 0.8991892576702127 1.0343127544808146 0.9527504577376333 0.6344257164810827 0.7382189451514217 0.7175306964863168 1.0 17.884561231602447 -5.3081857452748045 5.692287854336015 0.8453721413359353 0.5738341584526744 0.4469393377707681 0.12240016307608692 0.18623120572404983 15.071917974650114 0.035617138419835964 0.07785357035758877 4.918291381723577e-06 5.3081857452748045 -0.2715379828832609 SHT(ph)SLKDELSDVSQGGSK ddPTM_A459_Selumetinib_30min_R2 1 SHTSLKDELSDVSQGGSK 18 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9 A0A087X2D8 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 S(0.013)HT(0.55)S(0.437)LKDELSDVSQGGSK 95.197 0.0056198 8805000.0 25266.0 22095.0 23771.0 21372.0 23108.0 18147.0 23195.0 23256.0 15132.0 18122.0 True False 23861.816867811704 23789.615453377384 22241.599739907895 18461.096731243593 20204.966451858912 20646.584527935604 24273.61346002055 23323.67110976193 18158.82282340611 17598.770773389395 1.3558797472316921 1.3517771076005485 1.2638155258854096 1.0489992152837229 1.1480896428522311 1.1731833315969273 1.379278915134459 1.3253011480227355 1.0318233618261312 1.0 14.103187043578648 -5.524185744016714 24.981459917977112 1.179180554824099 1.3423204264778774 0.30912255983313985 0.11551340691296337 56.96100139045114 1088723.6431516502 0.032807673258879844 0.05739399580784217 2.9909851443780403e-06 5.524185744016714 0.1631398716537784 SHTEEDCTEELFDFLHAR ddPTM_A459_Selumetinib_30min_R1 1 SHTEEDCTEELFDFLHAR 18 0 P07919 P07919 UQCRH Cytochrome b-c1 complex subunit 6, mitochondrial 0 244.0 1.0580999999999998e-25 4591800.0 1407.9 1304.1 1301.3 1288.9 988.33 1397.2 968.59 1655.4 555.58 710.05 False True 1440.7013307034877 1151.4153657403574 1124.5906075292414 1063.8178106494993 898.9357260038335 1383.1454365560978 895.5284764837174 1611.493414502979 942.7786820422818 801.1918339726959 1.7981977219610377 1.437128184433788 1.4036471165126312 1.3277941256272883 1.1219981131690724 1.7263598777558615 1.1177453869484102 2.0113702438932965 1.1767202835399981 1.0 9.646003906547994 -4.7523615254039555 3.6615110657799823 1.3925950353949121 1.8572397833976426 0.16092478898352636 0.29122718557579547 0.5872538701087704 12.985772696936001 0.06866213363202196 0.7807893899385283 1.7686360566338203e-05 4.7523615254039555 0.4646447480027305 SHTPS(ph)PTSPK ddPTM_A459_Selumetinib_30min_R1 5 SHTPSPTSPK 10 0 B7Z385;A0A087X0J3;A0A087WZ15;E9PDI2;P40123-2;P40123 B7Z385 CAP2 Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 1 SHTPS(0.995)PT(0.005)SPK;SHTPS(0.997)PT(0.003)SPK;SHTPS(0.625)PT(0.294)S(0.082)PK;SHT(0.066)PS(0.909)PT(0.02)S(0.004)PK;SHTPS(1)PTSPK 117.03 0.0040688 50231800.0 35154.91 39295.7 43178.5 45947.100000000006 42809.899999999994 36145.020000000004 38262.8 35550.14 21797.489999999998 31649.859999999997 True False 35973.951003452916 34694.941175924694 37315.09686252315 37923.301518887136 38937.752103701714 35781.433915852365 35376.60619044297 34607.23480407092 36988.74850431945 35712.4278267433 1.007323029898118 0.9715088916453712 1.0448770675450882 1.0619076838704375 1.090313777954439 1.0019322710134368 0.9905965050057772 0.9690529854751361 1.0357388381369126 1.0 15.124138595090383 -9.432121832098861 10.179846141900489 0.9999977372462556 1.0191159510048537 0.02348513790776885 0.03722990966456706 0.0 0.0 0.03996451568773127 0.00969281879159824 3.697244468848593e-10 9.432121832098861 0.019118213758598124 SHTPS(ph)PTSPK ddPTM_A459_Selumetinib_30min_R2 1 SHTPSPTSPK 10 0 B7Z385;A0A087X0J3;A0A087WZ15;E9PDI2;P40123-2;P40123 B7Z385 CAP2 Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 1 SHTPS(0.971)PT(0.027)S(0.002)PK 89.44 0.0204 12314000.0 34074.0 31979.0 35555.0 34632.0 35769.0 30203.0 29973.0 28578.0 25589.0 34522.0 True False 32180.30348902938 34431.686471308225 33267.43000935701 29915.06185646773 31275.378441082787 34363.18909446402 31366.803890372747 28661.157248657422 30707.515016398298 33525.26016107208 0.9598822897844533 1.0270371148764013 0.9923093765573683 0.8923140853416452 0.9328899549420425 1.0249939576715024 0.9356170165323391 0.8549122992917854 0.9159515800582626 1.0 15.032960907253612 -5.657825069118341 8.621863504891135 0.9341682826798945 0.9973124004214617 0.22121930882570484 0.04821139780173915 0.381550954524723 28.726090396621494 0.01380281071319092 0.023941337117649304 2.1987453342019205e-06 5.657825069118341 0.06314411774156725 SHTPSPT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 SHTPSPTSPK 10 0 B7Z385;A0A087X0J3;A0A087WZ15;E9PDI2;P40123-2;P40123 B7Z385 CAP2 Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 1 SHTPSPT(0.798)S(0.202)PK;SHTPS(0.012)PT(0.653)S(0.336)PK 134.18 0.0029077 126161000.0 172707.0 152307.0 153447.0 141857.0 140846.0 107404.0 143160.0 129932.0 101875.0 139097.0 True False 163108.63634089901 163988.4571558069 143574.38708046105 122535.83188302568 123151.66630078427 122197.92608356175 149817.22366615824 130310.0806085996 122252.84662533006 135080.9081925917 1.2074884491326245 1.2140017368109504 1.0628769750034532 0.9071291681598714 0.9116881722856104 0.904627661440786 1.1090925110790357 0.9646817033744687 0.9050342366000972 1.0 17.043464258632355 -5.438610829604376 3.106436695750638 0.9586344888333119 1.2117163278668126 0.7378206441120205 0.05993339428865746 0.13297875573426543 2.4496259082400496 0.017534946660502856 0.04071743001285755 3.6424128579963682e-06 5.438610829604376 0.2530818390335007 SHTPSPTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 SHTPSPTSPK 10 0 B7Z385;A0A087X0J3;A0A087WZ15;E9PDI2;P40123-2;P40123 B7Z385 CAP2 Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 1 SHTPSPT(0.069)S(0.931)PK;SHTPSPT(0.009)S(0.991)PK;SHTPSPT(0.009)S(0.991)PK;SHTPSPT(0.146)S(0.854)PK 151.16 0.00045139 308911400.0 33364.0 42521.5 44248.0 47027.600000000006 35699.6 36064.200000000004 36432.0 34826.8 21697.999999999996 34005.6 True False 34141.31628495712 37543.06301229097 38239.36463686613 38815.11247738413 32470.577483276284 35701.42689167365 33683.90490842853 33903.08013061035 36819.92124078158 38370.550002594035 0.8897791739406655 0.9784343203251681 0.996581092381552 1.01158603342303 0.8462369572779415 0.9304382368576958 0.8778582768855628 0.8835703457031067 0.9595880496446461 1.0 15.227711824196383 -6.247922158183314 24.998000177666142 0.9092471200854034 0.9717255167743579 0.19799254476136563 0.05079475411729355 1104.6339790581662 2042848.7570169126 0.014661425840081774 0.01881805307885723 5.650382417257619e-07 6.247922158183314 0.062478396688954496 SHTPSPTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SHTPSPTSPK 10 0 B7Z385;A0A087X0J3;A0A087WZ15;E9PDI2;P40123-2;P40123 B7Z385 CAP2 Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 1 SHTPSPT(0.013)S(0.987)PK 153.75 0.00038595 102430000.0 124400.0 123220.0 118460.0 117180.0 107530.0 73977.0 111200.0 99128.0 68451.0 105050.0 True False 117486.3460126565 132670.57778525254 110838.41256949602 101219.88185322518 94021.12006960319 84166.66025365576 116371.02033861978 99416.4460684762 82143.11268074096 102016.93354732105 1.151635732690984 1.30047604032043 1.0864707329992729 0.9921870647707112 0.9216226836105698 0.8250263689274159 1.1407029822616706 0.974509256567307 0.8051909602109191 1.0 16.6384491160169 -5.592521503747975 2.5461695474958943 0.9492025673807615 1.225720968147012 0.5735685102804658 0.09509432475385274 0.19953824336688064 2.5961526746747996 0.027601841345320628 0.05853429776777053 2.555515363608288e-06 5.592521503747975 0.27651840076625056 SHTS(ph)EGAHLDITPNSGAAGNSAGPK ddPTM_A459_Selumetinib_30min_R1 1 SHTSEGAHLDITPNSGAAGNSAGPK 25 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 S(0.24)HT(0.266)S(0.296)EGAHLDIT(0.197)PNSGAAGNSAGPK 50.865 0.017113 31559000.0 4902.4 5035.0 4950.4 5630.5 7786.7 4787.0 7468.3 4292.0 1414.5 3027.1 True False 5016.616381590155 4445.499859292006 4278.1628706007505 4647.238872575069 7082.394359853539 4738.847126248242 6904.9601182371725 4178.1622176191795 2400.303189007535 3415.6577714509526 1.4687116559277318 1.3015062271310576 1.2525150810947345 1.3605692324968925 2.0735081889790665 1.3873893239120398 2.0215608764879227 1.2232379521571095 0.7027352708078536 1.0 11.737947717417853 -8.000765055735219 24.999005003652425 0.8885738450567812 1.5434846231835067 0.507993324382112 0.27623635636422383 22.073627095130185 721263.2113968811 0.15836105184695076 0.0746061178004266 9.982399447857869e-09 8.000765055735219 0.6549107781267255 SHVEDGDIAGAPAS(ph)SPEAPPAEQDPVQLK ddPTM_A459_Selumetinib_30min_R1 1 SHVEDGDIAGAPASSPEAPPAEQDPVQLK 29 0 Q9P2E9;A0A087WVV2;Q9P2E9-3;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 SHVEDGDIAGAPAS(0.5)S(0.5)PEAPPAEQDPVQLK 147.49 1.1122e-15 43745000.0 3744.0 5966.3 5499.2 6537.4 6005.0 5875.6 5562.5 4966.5 2536.8 3896.8 True False 3831.227915444177 5267.762822342379 4752.438844943365 5395.765812196475 5461.84881026886 5816.496798617955 5142.91614660556 4834.772286534404 4304.76431945869 4396.992238046335 0.871329242361015 1.1980377806359157 1.0808385795684192 1.2271492693364212 1.242178406186057 1.322835357381102 1.1696441267521211 1.0995635254254128 0.9790247711174893 1.0 12.102301270443954 -8.070985546461888 2.947097449078139 0.989585840243129 1.1689212492452874 0.25280233339906144 0.11407497675373197 0.3779854795399405 6.088091535823101 0.09332536161780335 0.03142306209830916 8.492087366585788e-09 8.070985546461888 0.17933540900215839 SHVEDGDIAGAPASS(ph)PEAPPAEQDPVQLK ddPTM_A459_Selumetinib_30min_R1 3 SHVEDGDIAGAPASSPEAPPAEQDPVQLK 29 0 Q9P2E9;A0A087WVV2;Q9P2E9-3;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 SHVEDGDIAGAPAS(0.349)S(0.651)PEAPPAEQDPVQLK;SHVEDGDIAGAPAS(0.152)S(0.848)PEAPPAEQDPVQLK;SHVEDGDIAGAPAS(0.035)S(0.965)PEAPPAEQDPVQLK 200.4 5.860800000000001e-42 78026000.0 4981.6 7431.3 7368.1 8316.099999999999 7401.4 7031.9 6960.099999999999 7019.9 2805.75 5474.8 True False 5097.661587493782 6561.239941282356 6367.55249007623 6863.849247530684 6731.944676823301 6961.165470454356 6435.094053391344 6833.709448151185 4761.152826127887 6177.543909067975 0.8251922871824446 1.0621114212804148 1.0307579490822143 1.1110967964882106 1.0897445288800822 1.1268500188620447 1.0416913498494624 1.1062178672854157 0.7707193823647329 1.0 12.592817644715456 -8.247813973471448 24.985012866735204 0.8853596757410213 1.0547746261000903 0.3169580635531414 0.09593279903930949 758.9280451737951 1391658.7893545139 0.06364067471528297 0.023768514983943903 5.651790128298089e-09 8.247813973471448 0.16941495035906906 SHVEDGDIAGAPASS(ph)PEAPPAEQDPVQLK ddPTM_A459_Selumetinib_30min_R2 1 SHVEDGDIAGAPASSPEAPPAEQDPVQLK 29 0 Q9P2E9;A0A087WVV2;Q9P2E9-3;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 SHVEDGDIAGAPAS(0.395)S(0.605)PEAPPAEQDPVQLK 111.27 4.2159e-11 7299200.0 24717.0 19612.0 24415.0 26002.0 26233.0 19989.0 20440.0 25772.0 21095.0 20544.0 True False 23343.328089990584 21116.177337480738 22844.165481042077 22460.48274404811 22937.376014004443 22742.30330792443 21390.500501091614 25846.99225321573 25314.589443546913 19950.84134027765 1.1700422900393694 1.0584103686319462 1.1450226630254061 1.1257912566676516 1.149694673161349 1.1399170050042577 1.072160323279576 1.295533948286916 1.2688482160619807 1.0 14.284161966691435 -7.747872936817805 24.999932285065224 1.2116433449061683 1.1231519939164525 0.09952678741109977 0.08097170156377007 346.6951690822527 638884.408166839 0.03610620861933392 0.020704928767660544 1.7870103307597775e-08 7.747872936817805 -0.08849135098971583 SHVSSEPYEPIS(ph)PPQVPVVHEK ddPTM_A459_Selumetinib_30min_R1 2 SHVSSEPYEPISPPQVPVVHEK 22 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 SHVSSEPY(0.001)EPIS(0.999)PPQVPVVHEK;SHVSSEPYEPIS(1)PPQVPVVHEK 111.82 2.2618000000000006e-05 34265000.0 4772.0 5944.0 5688.3 6564.7 11060.0 6339.4 9618.1 5616.1 1581.88 3280.7 True False 4883.178315304382 5248.073716709366 4915.860103595315 5418.298379680944 10059.624952801596 6275.6313917146645 8892.598973423266 5467.142784336223 2684.3348240560213 3701.8098017241355 1.3191326882947951 1.4177048518984012 1.3279612856678185 1.463689025070209 2.7174883345212058 1.6952873669500144 2.4022301116825333 1.4768837615022454 0.7251412060138205 1.0 11.85401505638097 -6.019771557417343 24.88248769157205 1.7639395465384848 1.3669790820008978 0.047470995858304166 0.55433515807305 1804.4107597438324 2270849.952358835 0.16672260362541572 0.21841283714476795 9.554950523644017e-07 6.019771557417343 -0.39696046453758704 SHVSSEPYEPIS(ph)PPQVPVVHEK ddPTM_A459_Selumetinib_30min_R2 5 SHVSSEPYEPISPPQVPVVHEK 22 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 SHVSSEPYEPIS(1)PPQVPVVHEK;SHVSSEPYEPIS(1)PPQVPVVHEK;SHVSSEPYEPIS(1)PPQVPVVHEK;SHVSSEPYEPIS(1)PPQVPVVHEK;SHVSSEPYEPIS(1)PPQVPVVHEK 129.04 1.7363e-05 32340400.0 90468.4 88851.1 131759.0 189587.0 241349.0 129305.4 99257.0 120408.9 125935.3 175537.2 True False 85440.52850169943 95665.69366868428 123281.76938835248 163764.92354418297 211028.58093256425 147116.0451324476 103872.64717401416 120759.2699642335 151125.8789262815 170468.98493558116 0.5012086423462117 0.561191196773041 0.7231917843292118 0.9606728379714844 1.2379294744572464 0.8630076913289625 0.6093345790336394 0.7083943745536319 0.8865300569683731 1.0 17.37914975415633 -5.42579494319444 2.8700982971027353 0.8827600772790369 0.5256524501392006 0.4520585326026384 0.15974941396982267 0.2863801908449766 4.50449302456416 0.050402009931980754 0.12214195664685785 3.7515009158111747e-06 5.42579494319444 -0.35710762713983635 SHVTEEEEEEEEEES(ph)DS ddPTM_A459_Selumetinib_30min_R1 1 SHVTEEEEEEEEEESDS 17 0 O75971-2;O75971 O75971-2 SNAPC5 snRNA-activating protein complex subunit 5 1 SHVTEEEEEEEEEES(0.5)DS(0.5) 151.15 0.00022632 1870700.0 399.27 348.82 243.97 383.65 296.52 333.13 387.21 178.67 0.0 170.28 True False 408.57221415582137 307.9799922379816 210.84021403128327 316.65272950242866 269.6998183548578 329.7790146578393 358.0024379554404 173.93109119804726 0.0 192.13709666765817 2.1264618922733782 1.6029179038272774 1.0973425626180668 1.6480561796462796 1.4036842600019133 1.7163734665370842 1.863265575281808 0.9052447143973344 0.0 1.0 7.585992282497852 -7.941402636796949 4.793780857468303 0.47972332119371025 1.6050978478283016 0.6545791140929199 0.3407299262652141 0.1137781820515396 5.293303466890645 0.19755304057337475 0.08879046403015793 1.1444514222587781e-08 7.941402636796949 1.1253745266345914 SHVTEEEEEEEEEES(ph)DS ddPTM_A459_Selumetinib_30min_R2 1 SHVTEEEEEEEEEESDS 17 0 O75971-2;O75971 O75971-2 SNAPC5 snRNA-activating protein complex subunit 5 1 SHVTEEEEEEEEEES(0.632)DS(0.368) 189.99 1.4319e-14 0.0 3817.7 3252.0 5404.5 4630.9 5114.1 2756.4 4172.8 2516.4 2746.2 2893.1 True False 3605.527517463973 3501.4179431719026 5056.780353974686 4000.163431251921 4471.621037365917 3136.069079892084 4366.843468246338 2523.722307387554 3295.516735239089 2809.568685823467 1.2833028555794908 1.2462474972900186 1.7998422247123582 1.4237642423322703 1.5915685065571952 1.116210148453061 1.5542753911945892 0.8982596937820961 1.1729617972565043 1.0 11.456132955113915 -7.760938548873889 24.99999999239813 1.026708019787262 1.4316640604462723 0.4840739448470689 0.1925421347966797 11.565807446308902 577439.1660792268 0.09682444753175569 0.051507798504648386 1.7340493422167706e-08 7.760938548873889 0.40495604065901025 SHWDDSTS(ph)DSELEK ddPTM_A459_Selumetinib_30min_R2 3 SHWDDSTSDSELEK 14 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 SHWDDS(0.001)T(0.025)S(0.974)DSELEK;SHWDDS(0.002)T(0.096)S(0.901)DSELEK;S(0.002)HWDDS(0.003)T(0.173)S(0.821)DSELEK 105.39 0.0038735 25651500.0 281546.0 222682.0 237329.0 250908.0 244268.0 173676.0 216499.0 209526.0 147858.0 218683.0 True False 265898.8004379371 239760.99336451598 222059.51052427795 216733.89755955737 213580.87005637324 197598.29252624363 226566.6324846297 210135.68597110332 177433.731497699 212369.05358332986 1.25206001510763 1.1289827275631663 1.045630268522837 1.0205531074447003 1.0057061820100257 0.9304476767784321 1.0668533322616562 0.9894835543383433 0.835497114592909 1.0 17.696214026385704 -1.5228788364818793 0.4866501822930355 0.9611360367019753 9.608408031307313 0.7266821255548911 0.05523191351318264 53.59664271968507 0.5903703548857879 0.03158945722712366 470.52869101787024 0.02999999370002135 1.5228788364818793 8.647271994605338 SIDAVIATASAPPSS(ph)SPGR ddPTM_A459_Selumetinib_30min_R2 1 SIDAVIATASAPPSSSPGR 19 0 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 SIDAVIATAS(0.001)APPS(0.022)S(0.488)S(0.488)PGR 150.9 2.4329e-05 5552100.0 41246.0 38413.0 41969.0 49490.0 44067.0 35471.0 38332.0 36353.0 36754.0 42601.0 True False 38953.712440820134 41359.1535827375 39268.76023239219 42749.3766249881 38530.909496021595 40356.80827632135 40114.51395341704 36458.78121143687 44105.826992563314 41370.998439309195 0.9415705182451617 0.9997136917884862 0.9491857028782864 1.0333174986748501 0.9313507275524429 0.9754854801371147 0.9696288575743366 0.8812642330815754 1.0661049686114317 1.0 15.336332155252984 -8.291962805085285 24.999820476994866 1.033052482377004 0.9634410498832077 0.33056300899807045 0.04126872273980492 927.4011153757787 759567.6842526899 0.03774387655905707 0.009750239215529321 5.105487237708182e-09 8.291962805085285 -0.06961143249379631 SIDAVIATASAPPSSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 2 SIDAVIATASAPPSSSPGR 19 0 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 SIDAVIATASAPPS(0.009)S(0.23)S(0.76)PGR;SIDAVIATASAPPS(0.162)S(0.162)S(0.676)PGR 182.49 2.9051e-13 44358000.0 5971.0 5957.4 7709.0 7434.3 7253.3 6250.2 6214.4 6307.6 3576.3999999999996 5721.8 True False 6110.112682456513 5259.904838479876 6662.160142505897 6136.03906409463 6597.240295674127 6187.328662727542 5745.642804757856 6140.301958027666 6068.889590078863 6456.248765051719 0.9463874309693776 0.8146998404014782 1.0318933462676958 0.9504031346049715 1.0218379953674661 0.9583473140347586 0.889935164186913 0.9510634087189603 0.9400024396411633 1.0 12.65648045268177 -5.260738254868118 24.999937282062604 0.9643584070740984 0.8805436406523732 0.3323185030374368 0.04934134531562217 70.93462207148471 2529187.02827721 0.012645670754661758 0.029692145586171236 5.486075058023547e-06 5.260738254868118 -0.08381476642172514 SIDAVIATASAPPSSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 SIDAVIATASAPPSSSPGR 19 0 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 SIDAVIATASAPPS(0.011)S(0.321)S(0.667)PGR;SIDAVIATASAPPS(0.006)S(0.225)S(0.769)PGR 308.39 1.1527999999999992e-116 10648400.0 64366.0 59532.0 61640.0 75288.0 68519.0 52335.0 57945.0 59414.0 53844.0 63098.0 True False 60788.795397513204 64097.91297444952 57674.149508557595 65033.644520955815 59911.03065236806 59543.67120017137 60639.55731583921 59586.8849034828 64614.30452706046 61276.19679170756 0.9920458282381469 1.0460491402939651 0.9412162067532653 1.0613198587050159 0.9777211019805941 0.9717259607768175 0.9896103297984952 0.97243118899877 1.0544764184157827 1.0 15.903039136342096 SIDDLEEK ddPTM_A459_Selumetinib_30min_R2 1 SIDDLEEK 8 0 P09493-3;P09493-9;Q6ZN40;P09493-2;H7BYY1;P09493-8;P09493-7 P09493-3 TPM1 Tropomyosin alpha-1 chain 0 134.91 0.037275 5457200.0 32467.0 30955.0 32679.0 35451.0 34397.0 28187.0 33757.0 31106.0 20788.0 33612.0 False True 30662.614115698678 33329.14896398716 30576.468718204953 30622.512643613918 30075.741346918425 32069.503393889943 35326.767388226515 31196.513310124483 24946.18086525023 32641.53422553607 0.9393741698486326 1.0210656378373648 0.9367350353980733 0.9381456285733458 0.921394844344958 0.9824753693348576 1.0822643060873571 0.9557306067347434 0.7642465790022326 1.0 14.994421248364796 -8.02526030262538 24.614847103561697 0.8747450229022189 0.97507773156471 0.21331273722029687 0.06967641566433472 850.3184182535454 828584.5919902853 0.04515062785407433 0.01723793693437019 9.434952050544321e-09 8.02526030262538 0.10033270866249111 SIEAVHEDIR ddPTM_A459_Selumetinib_30min_R1 3 SIEAVHEDIR 10 0 H7C312;H7BZ20;P23919-2;P23919 H7C312 DTYMK Thymidylate kinase 0 ;; 139.15 0.0021899000000000003 16435800.0 12823.599999999999 14029.6 15651.4 16490.4 15107.8 13167.4 14853.3 13073.4 7273.3 11634.3 False True 13122.364929618032 12387.00790981591 13526.025846986218 13610.661203145706 13741.302157498727 13034.947911042638 13732.903622539558 12726.650963611964 12342.258879185943 13127.67573267873 0.9995954498596062 0.943579668027671 1.0303442987486258 1.0367913924979637 1.046742960240288 0.9929364631238365 1.0461032022869237 0.9694519595674889 0.9401709130019377 1.0 13.680323887877357 -2.0324146025902516 6.716202072577685 1.002308301848732 1.0024440188676806 0.0 0.03789155416365604 0.0 0.0 0.009120138743578685 0.0 0.009280799650070655 2.0324146025902516 0.00013571701894865562 SIEAVHEDIR ddPTM_A459_Selumetinib_30min_R2 3 SIEAVHEDIR 10 0 H7C312;H7BZ20;P23919-2;P23919 H7C312 DTYMK Thymidylate kinase 0 ;; 161.51 0.00059601 14702500.0 139482.0 130212.0 151491.0 174375.0 183559.0 133222.0 134900.0 150800.0 124415.0 150661.0 False True 131730.1488306861 140198.8417024293 141744.23399092956 150624.82418634684 160498.67738171926 151572.12123109246 141173.117299279 151238.80303371625 149301.47644555056 146311.02546571154 0.9003432817956531 0.9582247220000883 0.9687870995350776 1.029483756995786 1.096969123624471 1.0359583001256039 0.9648836569214216 1.0336801519387857 1.0204389995239276 1.0 17.158678964250647 -5.311772888736571 1.6374567939258537 1.027448667719308 0.9103433927095482 0.5893250941686559 0.03329513192577767 0.34939420923882547 1.6166654913736735 0.010637225689513766 0.04632881810319527 4.877835063929592e-06 5.311772888736571 -0.11710527500975976 SIGS(ph)PESTPK ddPTM_A459_Selumetinib_30min_R2 1 SIGSPESTPK 10 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6;Q8NEY1-5;H0Y6F6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 S(0.006)IGS(0.786)PES(0.018)T(0.191)PK 129.82 0.0028839 31101000.0 246340.0 234850.0 265270.0 246490.0 221550.0 149470.0 206410.0 216390.0 125530.0 205150.0 True False 232649.40897715228 252862.23983822993 248202.81700413834 212917.63678103287 193716.9083178699 170058.13574643372 216008.47399365567 217019.6590747069 150639.5076012538 199226.78645628743 1.1677616906610002 1.26921808224674 1.2458305502939826 1.068719927517123 0.9723436881333903 0.8535907182528709 1.0842340923922413 1.089309640209066 0.756120752037055 1.0 17.604052108236395 -5.9442730123920695 2.8854838929505076 0.9658191861131958 1.2328808350292215 0.6051924754617481 0.09669221782269671 0.1818823052875709 3.079228265837954 0.029286602030428256 0.04537581710212385 1.136912359068965e-06 5.9442730123920695 0.2670616489160257 SIGVS(ph)NFNHR ddPTM_A459_Selumetinib_30min_R1 3 SIGVSNFNHR 10 0 P52895;B4DK69;S4R3P0 P52895 AKR1C2 Aldo-keto reductase family 1 member C2 1 SIGVS(1)NFNHR;SIGVS(1)NFNHR;SIGVS(1)NFNHR 103.97 0.0090275 25834000.0 7268.0 12269.0 11292.9 13474.099999999999 11985.8 10319.400000000001 11697.2 11643.7 4404.01 8805.6 True False 7437.330258933836 10832.539776296648 9759.386207459444 11121.101375182261 10901.686506264865 10215.596205265529 10814.870786530248 11334.871251932067 7473.283313836044 9935.884533807444 0.7485322754736001 1.0902441286871118 0.9822362744104509 1.1192864950616168 1.0972034215143323 1.0281516628445457 1.0884658280530535 1.1408014267239606 0.7521507811818614 1.0 13.278432692573206 -4.755693452309516 24.929193145312457 1.042242667851689 0.7485317858830697 0.39009201260850457 0.10622997588306497 176.28340332650674 764739.8158303214 0.02510931974013092 0.21693338631108947 1.7551189191698446e-05 4.755693452309516 -0.2937108819686193 SIGVS(ph)NFNHR ddPTM_A459_Selumetinib_30min_R2 4 SIGVSNFNHR 10 0 P52895;B4DK69;S4R3P0 P52895 AKR1C2 Aldo-keto reductase family 1 member C2 1 SIGVS(1)NFNHR;SIGVS(1)NFNHR;SIGVS(1)NFNHR;SIGVS(1)NFNHR 110.15 0.0063733 62636000.0 164212.0 124797.0 182935.0 162207.0 183344.0 112238.0 112533.0 132653.0 114335.0 150104.0 True False 155085.75443271972 134368.5286143988 171165.16126456842 140114.12677731778 160310.68760384378 127697.76570487885 117766.00747990918 133038.99826811362 137205.19478681884 145770.10750297114 1.0639064283434017 0.9217838342587491 1.1742130413197347 0.9611993101840988 1.099750081480706 0.8760216198803041 0.8078885959352732 0.9126631004604423 0.9412436962360221 1.0 17.153335376689213 -6.771319349822607 24.99969224993085 0.8958751458980279 1.0399863503904845 0.4188672911636754 0.07978587207860417 189.6028025193597 479756.7099857462 0.026934618186388596 0.024035542600685415 1.6930923607544383e-07 6.771319349822607 0.14411120449245662 SIGVSNFNHR ddPTM_A459_Selumetinib_30min_R1 2 SIGVSNFNHR 10 0 P52895;B4DK69;S4R3P0 P52895 AKR1C2 Aldo-keto reductase family 1 member C2 0 ; 219.5 0.00024744 140259000.0 19621.9 20032.8 20127.2 22194.0 24543.0 18771.1 22426.0 19559.1 6475.0 13109.900000000001 False True 20079.05209242898 17687.35046300394 17394.036790795777 18318.234532977724 22323.08998341859 18582.27977679513 20734.38876472383 19040.329131089307 10987.60208471106 14792.683366239911 1.3573637449885327 1.1956823535728671 1.1758540597504246 1.2383307395589822 1.5090629219012888 1.2561804587262304 1.4016651510329876 1.2871450472970603 0.7427727487081305 1.0 13.852596158019184 -8.249244781059085 24.592480958162046 0.8713863933993801 1.3013543276522626 0.7082950586718486 0.11070526423440287 281.0113398328992 566710.5877056239 0.0767937918849257 0.02852849948300845 5.633200626857313e-09 8.249244781059085 0.4299679342528825 SIGVSNFNHR ddPTM_A459_Selumetinib_30min_R2 2 SIGVSNFNHR 10 0 P52895;B4DK69;S4R3P0 P52895 AKR1C2 Aldo-keto reductase family 1 member C2 0 ; 181.53 0.00015145 140389000.0 701030.0 567570.0 891940.0 1003210.0 1070760.0 707240.0 608860.0 739520.0 663470.0 783880.0 False True 662069.5590454388 611100.7939748074 834553.5514708459 866571.0673662223 936241.5560841456 804655.890314497 637173.1964332026 741671.8807658735 796182.5389006924 761247.3476351671 0.869716736750773 0.8027624606814151 1.0962974834177175 1.1383567641427532 1.2298782504695775 1.0570229148438803 0.8370120413720931 0.9742850113959606 1.0458920367657796 1.0 19.53800577077564 -5.259182892646783 24.98480227710867 1.0490281623557833 0.836239582170509 0.42064005818061656 0.09908434584050148 205.8313410297063 2279017.3648413564 0.02929285874522122 0.07015474731294599 5.505757858635797e-06 5.259182892646783 -0.21278858018527436 SIKS(ph)DVPVYLK ddPTM_A459_Selumetinib_30min_R2 1 SIKSDVPVYLK 11 1 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2 H0Y2V6 CEP170 Centrosomal protein of 170 kDa 1 S(0.248)IKS(0.752)DVPVYLK 70.197 0.03682 3918300.0 51584.0 41755.0 51363.0 48314.0 47550.0 38293.0 38207.0 49375.0 35117.0 45469.0 True False 48717.167787113096 44957.474236513815 48058.36049980603 41733.54985370125 41576.34389760653 43567.5131607559 39983.701205734236 49518.673075528735 42141.381250961684 44156.191827350296 1.1032918775603682 1.0181465469734463 1.0883719476469602 0.9451347167092325 0.9415744922064178 0.986668264580059 0.9055061034717304 1.121443472053605 0.9543708256303788 1.0 15.430328134348926 -5.756814052948426 24.999979382822275 0.9799702466682602 1.0647577762597173 0.3386838204030397 0.05793430623990616 143.88179380893015 777671.3676247459 0.015811097085092707 0.026248961531656134 1.750596061487731e-06 5.756814052948426 0.08478752959145719 SILAKPSSS(ph)PDPR ddPTM_A459_Selumetinib_30min_R2 2 SILAKPSSSPDPR 13 1 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 SILAKPS(0.085)S(0.195)S(0.721)PDPR;SILAKPS(0.029)S(0.05)S(0.921)PDPR 156.6 0.0017335 21136800.0 55038.0 49210.0 62035.0 56726.0 56100.0 44639.0 41276.0 45275.0 33243.0 46637.0 True False 51979.20829457063 52984.24876491065 58043.73563860107 48999.82094219188 49052.21645963668 50787.61705750354 43195.415786842386 45406.74275432029 39892.52888702682 45290.46863252187 1.1476853709843433 1.169876363939058 1.2815883207029 1.0819013894461322 1.0830582667986262 1.1213753929018593 0.9537418598452063 1.0025672978290827 0.8808151050656399 1.0 15.466919846963913 -6.916200246448568 0.8678303215077714 0.9424355978624662 1.187463435672217 0.7118409165415376 0.059397472586228274 0.31997297013841947 0.5104636750552167 0.04040540292043302 0.03227866372472794 1.2128295046515946e-07 6.916200246448568 0.24502783780975068 SILFVPTSAPR ddPTM_A459_Selumetinib_30min_R2 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 150.81 0.0084073 2013600.0 8317.8 9377.4 11414.0 10133.0 14844.0 6959.9 9874.5 10224.0 7869.5 9312.7 False True 7855.529974791582 10096.616426906581 10679.635666623564 8752.867919600007 12979.164012956284 7918.56304931829 10333.683815950548 10253.75014732569 9443.619892201594 9043.818153699554 0.8686076877361937 1.1164108184524209 1.1808768691633684 0.9678288274758677 1.4351420818481293 0.8755774292165576 1.1426240156900267 1.1337855287516136 1.0442071845881258 1.0 13.14271626841524 -4.760055403146251 24.686376590722055 1.1070372970753326 0.8686073453400575 0.1893063767621782 0.14266466181569756 47.42524028150892 845571.031086735 0.03298451366028361 0.20069368159764384 1.7375791508406647e-05 4.760055403146251 -0.23842995173527515 SILPYPVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SILPYPVSPK 10 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 S(0.002)ILPYPVS(0.998)PK;SILPYPVS(1)PK 137.62 0.0017258 165274000.0 8613.9 15676.0 16625.5 17927.0 11766.2 13368.9 13319.599999999999 10776.5 6232.0 9807.1 True False 8814.587110268321 13840.646632425309 14367.848417334513 14796.385981467582 10701.949287491327 13234.421003989988 12314.89184832851 10490.672212994661 10575.248832728854 11065.936814243547 0.7965513682422807 1.2507433274524293 1.2983851849615573 1.337111012817494 0.9671073915510061 1.1959602902264246 1.1128648260920275 0.9480148304743226 0.9556578001707815 1.0 13.433837970774494 -7.678444008018968 4.343037678456659 0.9633892004622533 1.154020012944203 0.20473442944862152 0.15172209272558923 0.32604955249513723 11.313896637874254 0.07859747969267389 0.042499122739513964 2.0967950949014798e-08 7.678444008018968 0.1906308124819498 SILPYPVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SILPYPVSPK 10 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 SILPYPVS(1)PK;SILPY(0.003)PVS(0.997)PK 137.95 0.0016905000000000002 39751000.0 155593.0 159220.0 145140.0 141576.0 129527.0 106531.0 126104.0 138039.0 91999.0 146533.0 True False 146945.76394812917 171431.66202700854 135801.85041648347 122293.10456777777 113254.66027392793 121204.67825786682 131968.0858703357 138440.67063641318 110401.37066683438 142302.2115515434 1.032631624947753 1.2047013195217569 0.954320027326452 0.859390049068084 0.7958742105206557 0.8517413533939714 0.9273790226551427 0.9728638025155952 0.7758232951063153 1.0 17.118598557732348 -5.451873710731297 4.646296977261469 0.8803513905612983 1.1163291748419755 0.5908980882670591 0.07718956797655405 0.13749911311402577 5.585630782119211 0.020195051344418288 0.04290767590074063 3.5328588749123093e-06 5.451873710731297 0.23597778428067717 SILS(ph)PGGSCGPIK ddPTM_A459_Selumetinib_30min_R2 3 SILSPGGSCGPIK 13 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 1 S(0.078)ILS(0.922)PGGSCGPIK;S(0.002)ILS(0.998)PGGSCGPIK;S(0.34)ILS(0.66)PGGSCGPIK 182.72 0.00010376 166237000.0 218028.0 207258.0 238205.0 261284.0 275372.0 177064.0 196215.0 208161.0 173610.0 198187.0 True False 205910.87659523662 223154.0221604931 222879.14963799444 225696.6684599591 240777.30750308544 201452.9587730418 205339.38629264655 208766.7140470911 208336.85106869796 192464.8263583334 1.0698623768889033 1.159453529160815 1.1580253589974683 1.1726644952764211 1.2510197944158548 1.0467001300173893 1.0668930535408228 1.0847006073640004 1.082467144832032 1.0 17.554235286607877 -6.793701270065164 24.999957949090803 1.0621172207298049 1.1624011780674566 0.5640671289072573 0.04646833186806517 158.08140770543073 122497.28075135476 0.01660253388447859 0.014643195809164716 1.6080469695535848e-07 6.793701270065164 0.10028395733765172 SILVS(ph)PTGPSR ddPTM_A459_Selumetinib_30min_R1 2 SILVSPTGPSR 11 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 S(0.008)ILVS(0.936)PT(0.056)GPSR;S(0.004)ILVS(0.994)PT(0.002)GPSR 158.34 0.00057195 53810000.0 5496.3 6541.3 7640.200000000001 7465.3 6440.4 5759.7 5955.2 5675.2 3551.2 5349.6 True False 5624.353096061917 5775.441555032131 6602.702804614545 6161.625496036704 5857.866957144974 5701.76264738918 5505.994469440974 5524.675260352369 6026.127030614039 6036.273269516701 0.9317591906358865 0.9567892799350595 1.093837622951619 1.0207664929871607 0.9704442949472347 0.9445832540722093 0.9121512932899104 0.915246048957407 0.9983191220063047 1.0 12.559442404584415 -6.498868273136184 4.010314657588176 0.946662677079235 1.0039699913544746 0.1614635545734039 0.04849825590579712 0.35860618553483864 12.899937414467288 0.01696570712331458 0.018336065449015504 3.1705289776940664e-07 6.498868273136184 0.05730731427523961 SILVS(ph)PTGPSR ddPTM_A459_Selumetinib_30min_R2 5 SILVSPTGPSR 11 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 S(0.007)ILVS(0.973)PT(0.02)GPSR;SILVS(0.979)PT(0.021)GPS(0.001)R;S(0.023)ILVS(0.489)PT(0.489)GPSR;S(0.1)ILVS(0.842)PT(0.058)GPSR;SILVS(0.994)PT(0.006)GPSR 151.13 0.0006014 97986800.0 107360.0 112603.0 118808.0 137144.0 134436.0 106347.0 106484.0 112120.0 103804.0 124150.0 True False 101393.36099613181 121239.28802428835 111164.02262836978 118464.7506134043 117546.9478069113 120995.33392805238 111435.71699404296 112446.25063753467 124567.70052609374 120565.4669195612 0.8409817801624688 1.0055888400048807 0.9220220803568583 0.982576135938175 0.97496365095435 1.003565423993074 0.9242755810699144 0.9326571987031452 1.0331955219748186 1.0 16.879457215520695 -4.752019362272794 24.996203302453896 0.9711435428774906 0.8409815236649832 0.5503427938691857 0.03627233904101791 290.1145995472452 769770.0668999283 0.008719071654922705 0.10835626263821795 1.7700300428120295e-05 4.752019362272794 -0.13016201921250736 SILYDER ddPTM_A459_Selumetinib_30min_R2 1 SILYDER 7 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 139.68 0.042113 6837800.0 62552.0 57724.0 57709.0 66793.0 66082.0 48958.0 54539.0 56790.0 49053.0 57014.0 False True 59075.61025549582 62151.245188085806 53996.065768808425 57695.67817564828 57780.188379424515 55701.520103525116 57075.1715669783 56955.249497909375 58864.97065533572 55367.85767983795 1.066965794434341 1.1225148993026328 0.9752240384852553 1.0420428131655526 1.0435691536691876 1.0060262837983827 1.0308358307271488 1.0286699158065757 1.0631614283456596 1.0 15.756761081037286 -5.249570648572153 24.999158429974685 1.0257047272996798 1.0947403478034827 0.5289660275994685 0.026764387995236012 566.777270017249 1193799.5286106574 0.0065003911555430735 0.016884392365340742 5.628975409548028e-06 5.249570648572153 0.06903562050380296 SIMVQS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 SIMVQSPEK 9 0 Q14191 Q14191 WRN Werner syndrome ATP-dependent helicase 1 S(0.001)IMVQS(0.999)PEK;SIMVQS(1)PEK 137.4 0.0025568 37763000.0 11388.3 13478.5 12580.0 12236.6 10626.5 12047.9 11801.0 10749.599999999999 6825.0 10866.3 True False 11653.62523222567 11900.430954015354 10871.705096993666 10099.707519430262 9665.334951260958 11926.709064617955 10910.841068960393 10464.48568837818 11581.526521722475 12261.095451725234 0.9504554693427423 0.9705846431805462 0.8866830161952561 0.8237198347566206 0.7882929375532239 0.9727278538509193 0.8898748983660469 0.853470697588097 0.9445751863951815 1.0 13.581800260060191 -8.525585726607588 5.33873682744714 0.9999437116001784 0.891515324309103 0.26372277394092725 0.05749684550186393 0.20302983946489964 26.374912240131152 0.05972479392445663 0.015512941114841434 2.9813589910140643e-09 8.525585726607588 -0.1084283872910754 SIMVQS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 3 SIMVQSPEK 9 0 Q14191 Q14191 WRN Werner syndrome ATP-dependent helicase 1 SIMVQS(1)PEK;S(0.004)IMVQS(0.996)PEK;SIMVQS(1)PEK 136.38 0.0026452 80834000.0 249293.0 211429.0 219370.0 216118.0 203376.0 171932.0 208475.0 204909.0 143479.0 192756.0 True False 235438.29305894815 227644.92444861415 205255.97303199716 186682.35557565547 177826.08867549148 195614.0723566995 218169.50058537547 205505.2512654889 172178.80913821596 187190.6334397664 1.2577461207999316 1.2161127950980786 1.096507711204705 0.9972847046095686 0.9499732193208899 1.0449992543010629 1.1654936819025048 1.097839392330577 0.919804618288335 1.0 17.514148722242346 -5.317039306213734 2.5711843578396207 1.0330367495345754 1.2501924458308546 0.6113735279862516 0.0667830435529643 0.21452853206915284 2.720378800287401 0.019986510539352225 0.05917871795184941 4.8190418047891446e-06 5.317039306213734 0.2171556962962793 SINEENGEVS(ph)EDQSQNK ddPTM_A459_Selumetinib_30min_R1 2 SINEENGEVSEDQSQNK 17 0 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 SINEENGEVS(1)EDQSQNK;SINEENGEVS(1)EDQSQNK 244.32 4.503e-23 17451400.0 5153.1 5092.1 5843.6 6043.799999999999 5588.9 5004.8 5393.0 5712.0 3224.6 4640.4 True False 5273.1572038128725 4495.914564746933 5050.07121659715 4988.36378617693 5083.384981800438 4954.456255994816 4986.201668070791 5560.49920480912 5471.910684534254 5236.040541323705 1.0070886889045714 0.8586477757886758 0.9644828333052706 0.952697701021971 0.9708452296504423 0.9462219050623122 0.9522847710438558 1.0619664154478432 1.0450474249290131 1.0 12.35426055240747 -7.751053278102181 24.332613483786332 1.0401301858214316 0.9480654445393116 0.5131573321897502 0.037976051136892744 103.69349573647749 242935.58385625778 0.01741548498806279 0.009903913543751471 1.7739718413516484e-08 7.751053278102181 -0.09206474128211994 SINEENGEVS(ph)EDQSQNK ddPTM_A459_Selumetinib_30min_R2 4 SINEENGEVSEDQSQNK 17 0 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 SINEENGEVS(1)EDQSQNK;SINEENGEVS(1)EDQSQNK;SINEENGEVS(1)EDQSQNK;SINEENGEVS(1)EDQSQNK 308.24 5.432899999999996e-103 41303100.0 213156.0 191035.0 216772.0 232741.0 230306.0 167702.0 197336.0 204726.0 166858.0 190274.0 True False 201309.64285107527 205686.77022566 202825.12552350786 201041.2742993811 201372.90131823666 190801.42825281603 206512.51501386572 205321.7187657862 200234.2624020551 184780.29522877716 1.089454060032933 1.1131423400476683 1.0976555983547343 1.0880016943931774 1.0897964042589938 1.0325853631556552 1.1176111324975524 1.1111667427069354 1.0836342812102573 1.0 17.495451391951413 -5.981540179108093 2.086332712340222 1.0783583086699553 1.1017034264687944 0.1084123686877625 0.03358852734184946 0.8928501200819221 7.824132199222493 0.010595111080410797 0.01693815283931277 1.0434215952634382e-06 5.981540179108093 0.023345117798839077 SINHQIES(ph)PSER ddPTM_A459_Selumetinib_30min_R1 2 SINHQIESPSER 12 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 SINHQIES(0.998)PS(0.002)ER;SINHQIES(0.99)PS(0.01)ER 182.72 0.00010424 37797000.0 6432.400000000001 7873.1 7395.9 7477.8 7422.400000000001 7311.8 7489.7 6995.5 3871.64 5325.36 True False 6582.262404728397 6951.313791895107 6391.577402770702 6171.942605690767 6751.045230531157 7238.249930583219 6924.745899007936 6809.956615413554 6569.890306602428 6008.921829399107 1.095414883336338 1.1568321221762738 1.063681236706962 1.027129788158346 1.1235035871994798 1.2045838065606929 1.1524107145358573 1.1333075730982758 1.0933559285891754 1.0 12.55289043850727 -4.466413471169333 17.84674500093476 1.1123905357429056 0.9226286751058203 0.0 0.05939127087047948 18369259.624238454 118265147.61563668 0.015321199392550682 127773731.76279972 3.416540150497164e-05 4.466413471169333 -0.18976186063708533 SINHQIES(ph)PSER ddPTM_A459_Selumetinib_30min_R2 3 SINHQIESPSER 12 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 SINHQIES(0.995)PS(0.005)ER;SINHQIES(0.988)PS(0.012)ER;SINHQIES(0.817)PS(0.183)ER 192.54 0.00014981 50283900.0 40867.9 39854.4 66343.0 80055.0 76222.0 46219.0 38817.0 46926.0 47824.0 54078.0 True False 38596.625725165926 42911.104327905996 62074.563608796896 69151.3708974223 66646.31092667437 52585.24771569157 40622.06741442631 47062.5468909825 57390.136314206575 52516.62762848205 0.7349410552065475 0.8170955803078536 1.1819982815334311 1.3167519321046142 1.269051611580047 1.0013066354468714 0.7735086818940217 0.8961456402706718 1.0927993457653289 1.0 15.680486655645536 -11.005817015087407 4.541314942881922 0.9999331554410561 1.0149016075125183 0.0 0.19487398028553513 0.0001492909598088399 1.699763909234493e-05 0.21357137468192908 0.05156733096373396 9.866951305419689e-12 11.005817015087407 0.014968452071462246 SIPAGAEPGEKGS(ph)AR ddPTM_A459_Selumetinib_30min_R1 2 SIPAGAEPGEKGSAR 15 1 A6NGP5;Q9H910;Q9H910-3;Q9H910-2;H3BU16 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 SIPAGAEPGEKGS(1)AR;SIPAGAEPGEKGS(1)AR 159.64 0.00064488 17022800.0 4631.6 4904.0 6254.799999999999 6290.0 5640.200000000001 5343.700000000001 5928.6 5332.299999999999 3471.4 4360.6 True False 4739.507268475225 4329.837400192252 5405.432515157075 5191.569577923308 5130.044905858187 5289.947229691402 5481.400928856757 5190.870082248542 5890.712258975443 4920.325485840909 0.963250760973838 0.8799900357511126 1.098592467248792 1.0551272660442792 1.0426230786196526 1.0751214009955528 1.1140321803162088 1.0549851015316307 1.1972200367489894 1.0 12.264538039510477 -5.266632131374706 24.997014405137605 1.080535490034779 0.9216203939688867 0.5900407317500187 0.052707280409608225 249.88023188008134 1202885.6273561926 0.013082897800421338 0.028610618948239134 5.412125623009909e-06 5.266632131374706 -0.15891509606589227 SIPAGAEPGEKGS(ph)AR ddPTM_A459_Selumetinib_30min_R2 4 SIPAGAEPGEKGSAR 15 1 A6NGP5;Q9H910;Q9H910-3;Q9H910-2;H3BU16 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 SIPAGAEPGEKGS(1)AR;SIPAGAEPGEKGS(1)AR;SIPAGAEPGEKGS(1)AR;SIPAGAEPGEKGS(1)AR 95.873 0.005795300000000001 40872600.0 167191.0 193620.0 192260.0 198543.0 179401.0 157236.0 169815.0 156397.0 134757.0 187825.0 True False 157899.19353860142 208470.0314135744 179890.20091686054 171501.10089422102 156863.04251471086 178893.83175370493 177711.73398203886 156852.08937708294 161712.16542517455 182402.00422204332 0.8656658911838825 1.142915245381831 0.9862292998594189 0.94023693229515 0.8599853010592848 0.9807668096449873 0.9742860816688458 0.8599252516224672 0.8865701126195827 1.0 17.476762056271248 -5.715877896416068 3.9279585753151744 0.9235386122472962 1.0164314027058794 0.13882641441922727 0.07764774311559375 0.334887688247194 10.722567300010907 0.021108637502190823 0.036877429716252776 1.9236324896496574e-06 5.715877896416068 0.09289279045858323 SIPLECPLS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 SIPLECPLSSPK 12 0 Q92667-2;Q92667;I3L2A2;I3L2N7 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 SIPLECPLS(0.98)S(0.02)PK 216.83 5.1238e-08 4137000.0 56479.0 30807.0 39421.0 44051.0 26835.0 26759.0 53776.0 43002.0 35062.0 39073.0 True False 53340.12328335064 33169.7978398822 36884.69577833955 38051.177807786444 23463.747392056153 30444.809355983292 56276.69055512248 43127.12870063569 42075.3797141333 37944.86096615404 1.4057272032417993 0.8741578436528972 0.9720603749540647 1.0028018772219838 0.6183643000559492 0.8023434157036279 1.4831175848903497 1.1365736387624168 1.1088558145374043 1.0 15.211616888097158 -7.236680926534128 24.99835673318444 1.1935179877316686 0.9315340683785212 0.21542379835170322 0.21940048867209855 1133.655626464774 1144642.3050001625 0.08525122494658083 0.06600365053429903 5.7985455552007774e-08 7.236680926534128 -0.26198391935314747 SIPLECPLSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SIPLECPLSSPK 12 0 Q92667-2;Q92667;I3L2A2;I3L2N7 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 SIPLECPLS(0.395)S(0.605)PK 84.352 0.032747000000000005 3732500.0 43550.0 29150.0 27834.0 33259.0 25402.0 21952.0 44589.0 30576.0 29183.0 34270.0 True False 41129.665344462934 31385.71126797693 26043.190743367817 28729.066825024853 22210.773663238706 24975.68873958463 46662.47685142733 30664.9710978707 35020.415441148594 33280.536055846715 1.2358474417432734 0.9430650760946231 0.7825351941346677 0.8632393053049318 0.6673802857612543 0.7504593284697681 1.402095109679872 0.921408568852769 1.052279187522168 1.0 15.022391050975669 -7.2101411948551135 24.999986636626083 1.0873984184256833 0.8628999921981202 0.2544876432125234 0.18393055224333388 506.19836317667045 246694.07250617063 0.07238350989877754 0.056067968386595654 6.163945712897636e-08 7.2101411948551135 -0.2244984262275631 SIPT(ph)DNQIK ddPTM_A459_Selumetinib_30min_R2 1 SIPTDNQIK 9 0 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 1 S(0.112)IPT(0.888)DNQIK 107.03 0.029998 3076100.0 54749.0 50413.0 52128.0 53833.0 53614.0 35242.0 46044.0 45305.0 35225.0 48671.0 True False 51706.26975761194 54279.51499665599 48774.14123267506 46500.852532895224 46878.53000475868 40096.265604976354 48185.13723445513 45436.830049353484 42270.98426873384 47265.741767555184 1.09394812868683 1.148390207512099 1.0319131660418643 0.9838172594768203 0.9918077713727471 0.8483155898020793 1.019451624633786 0.9613057650254179 0.8943260528231058 1.0 15.528507275818825 -5.5999730765690625 1.7036613403030796 0.9499687154576012 1.1254835272643895 0.6321022264134775 0.05008051297674032 0.23422860499453482 1.3403106654811487 0.015065291093848611 0.039288322015971995 2.5120421569447156e-06 5.5999730765690625 0.1755148118067883 SIPTDNQIK ddPTM_A459_Selumetinib_30min_R2 1 SIPTDNQIK 9 0 B4DLR8;P15559-3;P15559-2;P15559;H3BNV2 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 138.98 0.033519 10958000.0 47845.0 42354.0 43513.0 48599.0 47589.0 35881.0 33375.0 37126.0 24879.0 45816.0 False True 45185.96643871017 45602.41561042525 40713.42095337227 41979.73236204883 41610.44436894207 40823.28205471189 34927.00363130789 37234.03051345986 29855.495177340785 44493.17303573603 1.015570779868132 1.0249306241611111 0.9150487181633924 0.9435095206253676 0.9352096407132258 0.9175178857647093 0.7849969163416423 0.8368481718207472 0.6710129473877138 1.0 15.441296367694227 -6.983098281514399 1.6598033761617847 0.8074481361847241 0.9722549208845087 0.395505883828301 0.08231142735405098 0.34965817661029847 1.951661128784729 0.03776951765916437 0.028868097642582746 1.0396848569100749e-07 6.983098281514399 0.1648067846997846 SIQADGLVWGS(ph)SK ddPTM_A459_Selumetinib_30min_R1 2 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 1 SIQADGLVWGS(0.907)S(0.093)K;SIQADGLVWGS(0.859)S(0.141)K 162.64 0.00036328 27458000.0 4230.5 8663.3 7477.200000000001 8960.3 6699.4 7320.700000000001 7099.9 5664.4 2758.9 5634.4 True False 4329.062418879964 7648.996808541092 6461.837309319635 7395.551810662351 6093.440452875138 7247.06040466378 6564.348826837712 5514.1617114357105 4681.651797916504 6357.63012370362 0.6809239189206057 1.2031207635094678 1.0163908852179828 1.1632560666102565 0.9584452593674043 1.1398996581515544 1.0325150565716883 0.8673297445972605 0.7363831658689229 1.0 12.634273369992844 -7.7723143189860675 5.363511227376115 0.8482904935733389 1.0415932225964353 0.18727697871212945 0.14959937768071102 0.23673316296101243 20.248965942186384 0.07525956263995352 0.03780885355917191 1.689217924049718e-08 7.7723143189860675 0.19330272902309642 SIQADGLVWGS(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 1 SIQADGLVWGS(0.5)S(0.5)K 163.9 0.00036288 4560700.0 40943.0 40749.0 41862.0 40057.0 37691.0 25117.0 28792.0 34773.0 24102.0 40008.0 True False 38667.55196781505 43874.31727131362 39168.64449589937 34601.16749782074 32955.91961818479 28576.638760575224 30130.885050265653 34874.183673019965 28923.073466146863 38852.86508673232 0.9952303872956707 1.1292427771638405 1.0081275707328692 0.8905692648554899 0.8482236649630954 0.7355091753666765 0.7755125647234418 0.8975961900150571 0.7444257560306322 1.0 15.245733369276707 -5.814147389142912 2.1617436631373503 0.8213710121793701 1.0654111249626486 0.586076407271243 0.07952470423399378 0.1925847018172747 1.837289436084534 0.02320568697933909 0.04235765187202241 1.5340962589252345e-06 5.814147389142912 0.24404011278327842 SIQDLTVTGTEPGQVS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 SIQDLTVTGTEPGQVSSR 18 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 SIQDLTVTGTEPGQVS(0.662)S(0.338)R 141.74 0.00030729 13460000.0 50328.0 44313.0 56285.0 60683.0 64261.0 50246.0 46481.0 41682.0 43639.0 49341.0 True False 47530.971238946695 47711.66461124742 52663.684378474405 52417.87071598616 56187.95867937102 57166.930412225265 48642.45860035421 41803.28771917344 52368.019375536605 47916.39712668611 0.9919562840519836 0.9957272973822009 1.0990743782183152 1.0939443251002074 1.1726248643197388 1.1930556936716605 1.0151526725130955 0.872421346885697 1.0929039434471848 1.0 15.548231814327375 -7.510028079442812 24.899740741162198 0.9783549893533046 1.0920303285303352 0.26832080215074006 0.07801017868385898 765.0906012040334 1482464.9690701868 0.036071482681269446 0.0229899724796902 3.090095634974474e-08 7.510028079442812 0.11367533917703065 SIQDLTVTGTEPGQVSS(ph)R ddPTM_A459_Selumetinib_30min_R1 2 SIQDLTVTGTEPGQVSSR 18 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 SIQDLTVT(0.001)GT(0.035)EPGQVS(0.225)S(0.739)R;SIQDLTVTGTEPGQVS(0.422)S(0.578)R 224.8 4.6884e-15 66882000.0 5840.6 7081.4 7183.3 7619.299999999999 7674.1 6399.4 6768.1 6154.2 3622.1 5142.0 True False 5976.674616170744 6252.306395946453 6207.847315042495 6288.7322869747295 6979.979009972396 6335.027846190308 6257.576767971428 5990.970624341092 6146.439152282922 5802.0257873214605 1.0301013534326104 1.0776074814436265 1.069944799040334 1.0838856146963043 1.203024472111963 1.0918648207378807 1.0785158490066407 1.0325653218281987 1.0593608814552447 1.0 12.502340992324525 -7.663366811448297 2.8819445644334025 1.032911291384526 1.0952534849454123 0.289939546140894 0.0433216237852307 0.3854777935506938 6.40338540015158 0.02645986954771658 0.013198636783289261 2.1708668585416465e-08 7.663366811448297 0.06234219356088633 SIQDLTVTGTEPGQVSS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SIQDLTVTGTEPGQVSSR 18 0 Q9UG54;O43318-4;O43318-3;O43318-2;O43318 Q9UG54 DKFZp586F0420;MAP3K7 Mitogen-activated protein kinase kinase kinase 7 1 SIQDLTVTGT(0.002)EPGQVS(0.23)S(0.768)R 132.6 0.00047609 11423000.0 38781.0 37807.0 43786.0 42790.0 47124.0 36701.0 32010.0 43890.0 26795.0 33124.0 True False 36625.707272643325 40706.67533133463 40968.85643059218 36961.92818313277 41203.86182609483 41756.22961149304 33498.52842661167 44017.71263361934 32154.748714853748 32167.624053512325 1.1385891358253495 1.2654548332079856 1.2736052983720092 1.1490412882731065 1.280910948149304 1.2980824925717123 1.0413740340562712 1.3683855717908742 0.9995997423173947 1.0 14.973321759966526 -8.288649762010584 23.914299279592502 0.9997995880142366 1.2251599839739915 0.5078164042077207 0.08942929386301993 379.7210814967058 333718.69389954174 0.08026291756599041 0.020751156143663376 5.1445837071412905e-09 8.288649762010584 0.22536039595975488 SIQEIQELDKDDES(ph)LRK ddPTM_A459_Selumetinib_30min_R2 1 SIQEIQELDKDDESLRK 17 2 J3KTF8;J3QQX2;P52565;J3KRE2;J3KRY1;P52565-2;J3KS60 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 1 SIQEIQELDKDDES(1)LRK 52.569 0.035696 5567100.0 28375.0 24960.0 27770.0 22543.0 19365.0 18784.0 27582.0 21033.0 15336.0 25705.0 True False 26798.03109412482 26874.35174095041 25983.308433689876 19472.60451115592 16932.195574703466 21371.325495825324 28864.61765269615 21094.2025477994 18403.62852364237 24962.82986038927 1.0735173553639297 1.076574726954107 1.0408799234304718 0.7800639839337618 0.6782963177412541 0.8561259126208722 1.1563039052114117 0.845024489041262 0.7372412753910178 1.0 14.607493871206822 -5.663608531502165 6.368497586272986 0.8626878639827833 1.0700540324429904 0.33974870687959857 0.12740481903128212 0.26051765149136186 14.330425255985299 0.03758852417912117 0.06550615222369802 2.169658931496269e-06 5.663608531502165 0.20736616846020706 SIQEIQELDKDDESLR ddPTM_A459_Selumetinib_30min_R1 2 SIQEIQELDKDDESLR 16 1 J3KTF8;J3QQX2;P52565;J3KRE2;J3KRY1;P52565-2;J3KS60 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 0 ; 273.84 2.2153e-50 50057000.0 2795.1 3526.3999999999996 3474.6 3967.0 2866.3 2962.1000000000004 3449.2 3262.5 2153.5 2645.5 False True 2860.220391682162 3113.527448621115 3002.7684046116196 3274.237919812681 2607.0436710863664 2932.303963371615 3189.024067033147 3175.9679019064693 3654.332214583053 2985.075694352184 0.9581734885630369 1.0430313222917476 1.0059270558173483 1.0968693108880276 0.8733593174936699 0.9823214764434904 1.0683226804153867 1.0639488666620605 1.224200854101326 1.0 11.543551799898209 -7.55772283202314 2.421258890916112 1.1105110397117328 0.9962595007162638 0.27948133309591483 0.0751581967538629 0.3770717820250131 4.429007467057545 0.041917332750366236 0.021883091098485314 2.7687080790718455e-08 7.55772283202314 -0.11425153899546903 SIQEIQELDKDDESLR ddPTM_A459_Selumetinib_30min_R2 3 SIQEIQELDKDDESLR 16 1 J3KTF8;J3QQX2;P52565;J3KRE2;J3KRY1;P52565-2;J3KS60 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 0 ;; 180.56 2.8448000000000007e-06 37189100.0 74670.0 72013.0 73264.0 76016.0 68517.0 54532.0 64721.0 68197.0 53896.0 66019.0 False True 70520.14032769339 77536.16554170921 68550.27400381182 65662.4896650859 59909.281910248224 62043.28800779103 67730.6547422285 68395.44197937881 64676.70598006185 64112.85993203814 1.099937522713028 1.2093699395706297 1.0692125429512502 1.0241703417175654 0.9344347136246012 0.9677198626540615 1.0564285357730936 1.0667975512538415 1.0087945858073 1.0 15.968326145119699 -5.526716925540108 3.3443106786812824 1.0087687860990107 1.1543887121566279 0.6330453312011124 0.044174124697412574 0.15490494925433415 3.6124038922513826 0.013150415046018299 0.027272830760215475 2.973603604055438e-06 5.526716925540108 0.1456199260576172 SIQEIQELDKDDESLRK ddPTM_A459_Selumetinib_30min_R1 1 SIQEIQELDKDDESLRK 17 2 J3KTF8;J3QQX2;P52565;J3KRE2;J3KRY1;P52565-2;J3KS60 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 0 84.62 0.0077217 18489000.0 5216.0 5765.4 7189.6 7547.2 6353.4 6272.6 5415.9 5936.1 3622.0 5099.6 False True 5337.522651430774 5090.384287738257 6213.291809645915 6229.2231984901055 5778.736091783874 6209.503339065113 5007.374302633894 5778.655344829732 6146.269459586636 5754.183334310485 0.9275899534873546 0.8846406157040232 1.0797869043549417 1.0825555663732678 1.004266940423498 1.0791285189054873 0.8702145920128074 1.0042529076842803 1.068139317518484 1.0 12.490395472247275 -5.249970431837543 24.917132402794447 1.0216233135636383 0.9061152712185833 0.37020195414886237 0.06122401587598978 791.8864040786369 1720423.1546474514 0.016262480510925402 0.042154633386154695 5.623796124962871e-06 5.249970431837543 -0.11550804234505507 SIQGSSTSSS(ph)ASSTLSHGEVK ddPTM_A459_Selumetinib_30min_R2 1 SIQGSSTSSSASSTLSHGEVK 21 0 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 SIQGS(0.051)S(0.034)T(0.034)S(0.034)S(0.126)S(0.475)AS(0.126)S(0.034)T(0.085)LSHGEVK 112.74 6.0832e-05 2734200.0 16306.0 13361.0 10941.0 14059.0 13209.0 8586.2 16439.0 14961.0 8665.8 11207.0 True False 15399.777798089828 14385.745737613726 10237.067971660106 12144.13994687226 11549.567330041737 9768.87111223676 17203.446073260526 15004.53403307311 10399.202142682569 10883.424790717076 1.4149753495999657 1.3218032020475692 0.9406108985465427 1.1158380914462238 1.0612070696618257 0.8975916405072267 1.5807015166709342 1.3786592292043125 0.9555082469584831 1.0 13.409844994142993 -5.0349354852727775 12.099514556117374 1.136196326288734 1.3917843079002692 0.19999723720759643 0.20231965176905461 2.1401633710438643 743.2273733691837 0.05425084467743018 0.14618423953427037 9.227084859190152e-06 5.0349354852727775 0.2555879816115352 SIQPQVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SIQPQVSPR 9 0 A0A2R8YCL1;Q13322-3;Q13322-2;Q13322-4;Q13322 A0A2R8YCL1 GRB10 Growth factor receptor-bound protein 10 1 SIQPQVS(1)PR;SIQPQVS(1)PR 150.09 0.0013571 76280000.0 5313.7 6219.1 6954.1 7351.8 6897.1 5266.0 5934.8 5503.5 3444.2 4778.5 True False 5437.498871339671 5490.964880818852 6009.771416137015 6067.946140377832 6273.258522781904 5213.028821145441 5487.133257865105 5357.529302112572 5844.555845584838 5391.867021531618 1.0084630888754913 1.0183791363717802 1.1145993386220188 1.12538868561602 1.1634668469623937 0.966831859971321 1.017668506280488 0.9936315715350688 1.0839577130232394 1.0 12.39656920073998 -6.777521684151826 24.999989076677853 1.0123480748134916 1.086069935615414 0.3368902634390396 0.05165831843510085 320.209240990942 497763.0624731988 0.01967500873283338 0.0174044255849606 1.6690844684027384e-07 6.777521684151826 0.07372186080192233 SIQPQVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SIQPQVSPR 9 0 A0A2R8YCL1;Q13322-3;Q13322-2;Q13322-4;Q13322 A0A2R8YCL1 GRB10 Growth factor receptor-bound protein 10 1 SIQPQVS(1)PR;SIQPQVS(1)PR;SIQPQVS(1)PR;SIQPQVS(1)PR 124.39 0.005326300000000001 181220000.0 491370.0 435406.0 503270.0 460534.0 463584.0 311855.0 346874.0 331100.0 299427.0 356345.0 True False 464061.62250995985 468800.2401490482 470890.156118945 397808.47473453695 405344.43342645693 354810.1955121704 363004.3283177915 332063.4461834445 359320.766689402 346056.393954499 1.3409999948475932 1.3546931897195003 1.3607324249609434 1.1495481132096712 1.1713247912990545 1.0252958815690092 1.0489744869893112 0.9595645449253155 1.0383300900276013 1.0 18.400647635561548 -6.166430256748499 0.9528166451572506 1.0018976476785757 1.3761542721500264 0.9213383256039678 0.041598176338950334 0.13876445429078746 0.26388791565983605 0.018340538978775092 0.03265217545324125 6.816630340481481e-07 6.166430256748499 0.3742566244714507 SIRPPQS(ph)PPQNCSR ddPTM_A459_Selumetinib_30min_R2 1 SIRPPQSPPQNCSR 14 1 Q96S21-2;Q96S21 Q96S21-2 RAB40C Ras-related protein Rab-40C 1 SIRPPQS(0.998)PPQNCS(0.002)R 70.117 0.032197 4003100.0 9912.8 12837.0 11018.0 12859.0 12719.0 8527.0 8716.3 11591.0 8853.4 12676.0 True False 9361.886260082474 13821.55662253928 10309.113875491363 11107.58201698772 11121.125510697311 9701.516849600863 9121.62522102079 11624.727891006656 10624.327384664533 12310.010943796702 0.7605099867762622 1.122789954098642 0.8374577344048879 0.9023210513541491 0.9034212529519726 0.788099774557039 0.7409924542445177 0.9443312393531724 0.8630640080802183 1.0 13.587544423951366 -4.484083208787632 18.051134819130123 0.8913930707416169 0.10410366029090584 0.1379704441817613 0.10266836771870408 6151106.3998775855 75312383.47752425 0.025551108621893824 163405923.85350055 3.2803243761401266e-05 4.484083208787632 -0.7872894104507111 SIS(ph)ADDDLQESSR ddPTM_A459_Selumetinib_30min_R1 2 SISADDDLQESSR 13 0 P18615;P18615-3;A0A0A0MT02;P18615-4;A2ABK4;A0A0G2JI50;E9PD43;A0A0A0MSN9 P18615 NELFE Negative elongation factor E 1 S(0.124)IS(0.876)ADDDLQESSR;S(0.005)IS(0.995)ADDDLQESSR 273.07 1.7533000000000004e-38 49786000.0 2091.21 2250.3 2863.6 2802.1 2441.0 1899.94 2169.06 2550.8 1500.17 2170.61 True False 2139.9311242136796 1986.8338298639128 2474.738848628861 2312.7658369314636 2220.211980993552 1880.8283286074966 2005.4460578797755 2483.144497833879 2545.6789219182992 2449.228937031861 0.8737162507997276 0.8112078866223468 1.0104154867727126 0.9442832403140834 0.906494263326871 0.7679267136565886 0.8188071060070476 1.0138474441034162 1.039379734343382 1.0 11.25811191805096 -7.779923293724298 23.62939995404702 1.0199604433452896 0.878418496354199 0.490686082453599 0.0660786258877374 125.91503716355876 160962.55252126715 0.03982479523571897 0.01920061606702146 1.659880054090214e-08 7.779923293724298 -0.14154194699109057 SIS(ph)CGPSSR ddPTM_A459_Selumetinib_30min_R1 1 SISCGPSSR 9 0 Q5VU43-13;Q5VU43-2 Q5VU43-13 PDE4DIP Myomegalin 1 S(0.051)IS(0.949)CGPSSR 106.16 0.013330000000000002 8661700.0 2043.4 2774.1 2503.4 2827.5 3852.2 2109.7 3030.4 2591.4 1167.2 1695.0 True False 2091.007244235744 2449.307082355897 2163.452030191888 2333.730203748514 3503.769190161148 2088.4783334543376 2801.8144882109636 2522.667653946491 1980.6531510849047 1912.5697606981469 1.0932972418598013 1.2806367290162657 1.131175486849777 1.2202065784500487 1.831969354614372 1.0919749837997954 1.4649476038919569 1.3189937987023488 1.0355978598981432 1.0 10.901296655514574 -8.280675150350142 5.895946846946006 1.0116185355668985 1.31100982372031 0.23246756144121106 0.2079665207446996 0.26005897735104566 33.74772894124304 0.18191764374832475 0.05240198478269833 5.2399223306284485e-09 8.280675150350142 0.29939128815341154 SIS(ph)CGPSSR ddPTM_A459_Selumetinib_30min_R2 3 SISCGPSSR 9 0 Q5VU43-13;Q5VU43-2 Q5VU43-13 PDE4DIP Myomegalin 1 S(0.014)IS(0.979)CGPS(0.006)SR;SIS(0.983)CGPS(0.017)SR;S(0.121)IS(0.879)CGPSSR 99.343 0.018892 24954900.0 54272.0 33456.5 47613.0 59182.0 55952.0 40408.9 39029.0 51313.0 37571.8 41798.0 True False 51255.779508029635 36022.50597039695 44549.631417114746 51121.30950535553 48922.80954277347 45974.8591795281 40843.925834496324 51462.31233467554 45087.2098438045 40591.18313575379 1.2627318434303578 0.8874465632086338 1.0975199039683634 1.2594190549801079 1.2052570475503328 1.1326316610621834 1.0062265418058216 1.2678199638222956 1.1107636279783748 1.0 15.308878771302433 -5.526506723012933 24.947228331495364 1.1505856888723947 1.0544377055936798 0.038026349421769856 0.12052957331581611 222.79562920670278 1532015.021069082 0.03136062640699316 0.05464945213125188 2.9750432039352455e-06 5.526506723012933 -0.09614798327871488 SIS(ph)ESSR ddPTM_A459_Selumetinib_30min_R1 1 SISESSR 7 0 Q9H307 Q9H307 PNN Pinin 1 S(0.22)IS(0.762)ES(0.018)SR 96.668 0.022997 8083600.0 1617.0 2361.0 2311.0 1959.0 1874.1 2094.2 1759.9 2354.9 1677.9 1792.5 True False 1654.6729538657141 2084.573022400879 1997.1788934143378 1616.897424984382 1704.587985899228 2073.1342493814636 1627.1493260963803 2292.440402206757 2847.273751032694 2022.5848354285724 0.818098170658488 1.0306480034293204 0.9874388744693365 0.7994213130950188 0.8427770029918359 1.0249924814363498 0.8044900256317793 1.13342113618735 1.407740086427265 1.0 10.981984501080136 -7.9149307643287115 5.528271551724804 1.2249135496245405 0.9091339526447616 0.5163678705589791 0.12435661684097411 0.1442648061496977 7.085973039834901 0.06731412914996134 0.03139883783067271 1.2163799017202535e-08 7.9149307643287115 -0.31577959697977886 SIS(ph)GTSTSEKPNSMDTANTSPFK ddPTM_A459_Selumetinib_30min_R2 3 SISGTSTSEKPNSMDTANTSPFK 23 1 Q9UJF2-2;Q9UJF2 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.44)IS(0.527)GT(0.008)S(0.008)T(0.008)S(0.008)EKPNSMDTANTSPFK;S(0.04)IS(0.764)GT(0.154)S(0.033)T(0.007)S(0.002)EKPNSMDTANTSPFK;S(0.27)IS(0.307)GT(0.122)S(0.122)T(0.122)S(0.046)EKPNS(0.01)MDT(0.001)ANTSPFK 83.723 0.0001857 38504400.0 61319.6 59930.5 74786.2 95058.3 80312.7 62275.3 66181.8 75654.5 59669.5 68023.7 True False 57911.70211380776 64526.97664307008 69974.53731305792 82111.19555528589 70223.1006213524 70853.15729611227 69259.38483674881 75874.64206972322 71605.06730513026 66059.67903420195 0.8766573341027644 0.976798216195717 1.0592624477758827 1.2429850819101522 1.0630251561621251 1.0725628451725981 1.0484365932339792 1.148577213498716 1.0839451288895487 1.0 16.011482339531803 -5.071327153290913 2.329928557053905 1.0985455269896518 0.878039494494313 0.5494807253142562 0.06234071924474269 0.25785882910559144 2.4258294571514836 0.01684187853564384 0.08944124081251914 8.48541029712677e-06 5.071327153290913 -0.22050603249533884 SIS(ph)KDSLASNIVNLTPQNQPHPTATK ddPTM_A459_Selumetinib_30min_R1 1 SISKDSLASNIVNLTPQNQPHPTATK 26 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 S(0.183)IS(0.739)KDS(0.055)LAS(0.023)NIVNLTPQNQPHPTATK 107.19 1.6626e-08 8835800.0 1965.7 1652.0 1826.5 2322.5 2762.0 1458.7 2243.2 1653.4 561.85 1372.5 True False 2011.4969854136264 1458.5830720060367 1578.4713322463367 1916.918973724464 2512.1775876707043 1444.026802393631 2073.9936179893175 1609.5464609998955 953.4184140995995 1548.673744282128 1.2988513512547701 0.9418272101475758 1.019240713593954 1.2377810244423253 1.6221477228150458 0.9324280260610959 1.3392062890242233 1.0393063528987407 0.6156354219988065 1.0 10.59681753138343 -8.024142720229326 7.544491272206424 0.8122284161089622 1.1897697544728396 0.3474644357968526 0.21312391783247506 0.23605809998436947 56.96657916142288 0.1370098391773095 0.055018346948155446 9.459262548202307e-09 8.024142720229326 0.3775413383638774 SIS(ph)LGDSEGPIVATLAQPLR ddPTM_A459_Selumetinib_30min_R1 2 SISLGDSEGPIVATLAQPLR 20 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 S(0.015)IS(0.985)LGDSEGPIVATLAQPLR;S(0.048)IS(0.952)LGDSEGPIVATLAQPLR 273.77 2.6024999999999996e-59 910760000.0 5806.1 5669.599999999999 6377.4 6890.1 6198.7 5410.1 6060.400000000001 5472.2 2986.04 4403.3 True False 5941.370833296059 5005.800596274466 5511.384108550667 5686.873378195453 5638.028679469372 5355.679305977772 5603.2591487439695 5327.059479789299 5067.091788267279 4968.506446774133 1.1958062039254413 1.0075061087068826 1.1092637531202167 1.1445840795653448 1.1347532180681652 1.0779254013960304 1.127755233644098 1.072165154026913 1.0198420476151648 1.0 12.278596521628343 -8.175274979439205 2.212158926311477 1.0017533582831628 1.1104164208127656 0.4463033315758014 0.0460230744510003 0.2962286380280021 2.584734035723668 0.04036619583143187 0.012166341488229487 6.679208804960324e-09 8.175274979439205 0.10866306252960278 SIS(ph)LGDSEGPIVATLAQPLR ddPTM_A459_Selumetinib_30min_R2 5 SISLGDSEGPIVATLAQPLR 20 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 S(0.032)IS(0.853)LGDS(0.115)EGPIVATLAQPLR;S(0.001)IS(0.999)LGDSEGPIVATLAQPLR;S(0.001)IS(0.999)LGDSEGPIVATLAQPLR;SIS(1)LGDSEGPIVATLAQPLR;S(0.068)IS(0.929)LGDS(0.003)EGPIVATLAQPLR 246.42 9.0907e-38 408497000.0 501705.9 484981.7 608493.6 691484.4 646372.2 467637.5 529902.8 503455.9 548835.92 556922.7 True False 473823.0945658457 522178.23692804767 569343.7842537381 597303.0318428758 565169.1455952149 532050.3208344341 554544.3301824786 504920.8733173888 658618.4397568788 540842.8945920499 0.8760826837213859 0.9654896868376523 1.052697169449154 1.1043928612456173 1.044978405460081 0.9837428320764982 1.0253334854306695 0.9335814122107372 1.2177629517600768 1.0 19.04485005165074 -4.943914204786318 2.6278977991335357 1.0418392949397477 0.868468561616912 0.3525928452165251 0.07233426944537243 0.38723984027049485 4.514668207557593 0.018449868907442765 0.1276675903948432 1.1378520471813389e-05 4.943914204786318 -0.1733707333228357 SIS(ph)LGGAYPNISCLSSLK ddPTM_A459_Selumetinib_30min_R2 2 SISLGGAYPNISCLSSLK 18 0 P46934-3;P46934-2;P46934;H0Y8X6;H0YA37 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 SIS(1)LGGAYPNISCLSSLK;S(0.002)IS(0.997)LGGAYPNISCLSSLK 203.23 8.813799999999999e-11 6080600.0 42079.0 39075.0 42717.0 43683.0 54753.0 34614.0 34710.0 36724.0 33374.0 39034.0 True False 39740.41763558337 42071.92685407201 39968.63472675299 37733.30004262184 47874.43864196949 39381.764305392775 36324.083776560205 36830.860760014526 40049.73254747264 37906.98699748823 1.0483665620329208 1.1098726168043835 1.0543870112758202 0.9954180754361222 1.2629449722591173 1.0389051577220385 0.9582424416629866 0.9716114014140714 1.0565264010596882 1.0 15.210176169307022 -6.99620240572202 24.99812666993726 0.9948499630904154 1.0937247683825244 0.3077506054137906 0.069192419786381 139.2163773205257 916398.7434542142 0.024554809705126395 0.021561243004468104 1.0087826269038267e-07 6.99620240572202 0.09887480529210901 SIS(ph)LSQSAENVPASK ddPTM_A459_Selumetinib_30min_R1 1 SISLSQSAENVPASK 15 0 Q4ADV7-2;Q4ADV7-3;Q4ADV7;H0YFN7 Q4ADV7-2 RIC1 RAB6A-GEF complex partner protein 1 1 S(0.159)IS(0.795)LS(0.045)QS(0.001)AENVPASK 136.36 0.000406 7546800.0 2037.9 1967.5 2104.2 2551.2 1992.4 2518.9 2300.0 2440.7 1344.0 1945.6 True False 2085.379104936883 1737.144185334065 1818.461197543248 2105.680811955157 1812.1877717867912 2493.5621529782115 2126.509148259376 2375.9647074890786 2280.669838123809 2195.336711748859 0.9499131016105582 0.7912882684634801 0.8283290612375435 0.9591607522828332 0.8254714468575337 1.1358449661199255 0.9686482883827633 1.0822780372475649 1.0388701769155817 1.0 11.100226516047092 -6.7519891477331875 24.999999999999627 1.0454906755180386 0.8689592036346684 0.64494890575664 0.06465281300565273 121.62347728385777 321746.89349459746 0.020659721734962135 0.020401179065029126 1.7701531908267295e-07 6.7519891477331875 -0.17653147188337026 SIS(ph)LSQSAENVPASK ddPTM_A459_Selumetinib_30min_R2 2 SISLSQSAENVPASK 15 0 Q4ADV7-2;Q4ADV7-3;Q4ADV7;H0YFN7 Q4ADV7-2 RIC1 RAB6A-GEF complex partner protein 1 1 S(0.032)IS(0.963)LS(0.001)QSAENVPAS(0.002)K;S(0.01)IS(0.988)LSQS(0.002)AENVPASK 83.85600000000002 0.022691 25045000.0 150605.0 103581.0 127361.0 140370.0 147830.0 97347.0 106352.0 112440.0 84890.0 103292.0 True False 142234.97701958288 111525.32963459069 119166.73192017178 121251.36384824393 129258.27378303204 110755.66562191803 111297.57873248994 112767.18178455585 101870.37202477822 100309.6915751537 1.4179584722680365 1.1118101140908607 1.1879882197712677 1.2087701790748742 1.2885920767305876 1.1041372362204707 1.1095396365475207 1.1241902952125897 1.0155586207585459 1.0 16.614101475321554 -7.405535181362603 0.40207014515962164 0.9825180006422686 1.272523965535748 0.5551130922178877 0.07944739034506561 0.9699476464860468 0.38645272609245207 0.08964122851695976 0.09547573170886132 3.9306540214375755e-08 7.405535181362603 0.2900059648934795 SIS(ph)LYYTGEK ddPTM_A459_Selumetinib_30min_R2 2 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 1 S(0.038)IS(0.962)LYYTGEK;S(0.013)IS(0.987)LYYTGEK 130.44 0.0027794 8226400.0 30736.0 43092.0 44692.0 34954.0 42694.0 30730.0 19830.5 30987.0 24636.0 37117.0 True False 29027.816165956647 46397.01783738124 41816.56537697042 30193.204900986762 37330.398030797296 34962.778560834355 20752.657543390298 31077.167039826007 29563.8883873535 36045.335768452394 0.8053140731556835 1.2871850642597937 1.1601103023589845 0.8376452669200121 1.0356512773413977 0.969966788086754 0.5757376676056224 0.8621688875215131 0.8201862392756073 1.0 15.137524967751423 -7.018759915938044 22.983919829502955 0.7987250624868727 1.0334139001626446 0.2707922198095737 0.16295163593904868 329.0497260470944 403137.8442208999 0.06123881587838913 0.04838928001374113 9.577233678488525e-08 7.018759915938044 0.23468883767577187 SIS(ph)NEGLTLNNSHVSK ddPTM_A459_Selumetinib_30min_R1 1 SISNEGLTLNNSHVSK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.033)IS(0.955)NEGLT(0.012)LNNSHVSK 72.207 0.037929 9217200.0 1265.8 1237.9 1355.0 1555.2 2516.3 1469.5 2149.9 1541.7 552.86 1043.6 True False 1295.2906771819553 1092.9660925159033 1170.9984424822271 1283.6135147196069 2288.7011092888474 1454.7181641992454 1987.7313121055806 1500.8091078526295 938.1630407032212 1177.55622552483 1.0999820213295137 0.9281646759829022 0.9944310234191321 1.0900655840425009 1.943602402737743 1.2353704499765061 1.6880139300521808 1.2745116329232835 0.7967033933221213 1.0 10.201580231420959 -6.020857810594575 24.901430712429867 1.365734973430266 1.0066994171625612 0.17816465678389592 0.3058904986779004 1089.1674929903013 1300319.7992403915 0.09004591500966709 0.11760844889115753 9.531081636138095e-07 6.020857810594575 -0.3590355562677048 SIS(ph)NEGLTLNNSHVSK ddPTM_A459_Selumetinib_30min_R2 3 SISNEGLTLNNSHVSK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.073)IS(0.927)NEGLTLNNSHVSK;S(0.185)IS(0.814)NEGLTLNNSHVSK;S(0.025)IS(0.974)NEGLTLNNSHVSK 126.09 0.00076126 43939000.0 117918.0 89642.0 185393.0 250754.0 296401.0 148141.0 139845.0 159079.0 161913.0 182266.0 True False 111364.58962315445 96517.25315554003 173465.0162206364 216600.87262522255 259164.4565214396 168546.07805989476 146348.0695976103 159541.8935530539 194300.1242272112 177003.50699605982 0.629166006443214 0.5452844115551256 0.9800089227864723 1.2237094976318417 1.4641769585232496 0.9522188623282287 0.8268088699557127 0.9013487713359565 1.0977190651456212 1.0 17.433418419353565 -5.329508837821971 4.509617633468753 1.065929596425238 0.5854556947905176 0.5489192984604434 0.17088119421950607 0.16813754671041733 6.655527250043595 0.05142754049476576 0.11587263147409703 4.6826442217191946e-06 5.329508837821971 -0.48047390163472037 SIS(ph)PEVSASR ddPTM_A459_Selumetinib_30min_R2 4 SISPEVSASR 10 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 S(0.132)IS(0.844)PEVS(0.023)ASR;S(0.295)IS(0.704)PEVSASR;S(0.016)IS(0.974)PEVS(0.007)AS(0.003)R;S(0.118)IS(0.765)PEVS(0.118)ASR 155.33 0.00052713 88526000.0 321577.0 317253.0 389548.0 438438.0 433360.0 349212.0 317183.0 343150.0 342099.0 363259.0 True False 303705.0377147265 341585.2849708228 364484.9057877934 378721.9880522633 378917.44251244504 397312.78316908865 331932.63798619126 344148.5096884597 410528.35904470074 352770.7688097705 0.8609132744739902 0.9682924867140015 1.0332060873908169 1.0735639728032194 1.0741180279502522 1.1262633366976535 0.9409301091077189 0.9755584649192962 1.1637255559178024 1.0 18.428371496102244 -4.861113931714769 1.8112938553557023 1.0493209630463762 0.8180772812746282 0.46358709072853543 0.06321741490375736 0.6704840055842898 2.6043347801413477 0.017823597216362348 0.2545333463812772 1.376848222635194e-05 4.861113931714769 -0.23124368177174803 SIS(ph)PSALQDLLR ddPTM_A459_Selumetinib_30min_R1 1 SISPSALQDLLR 12 0 Q92793-2;Q92793 Q92793-2 CREBBP CREB-binding protein 1 S(0.002)IS(0.997)PS(0.002)ALQDLLR 195.94 0.00016555 15258000.0 1005.1 1079.2 1100.0 1192.8 1146.5 1057.4 1088.6 837.33 522.31 787.42 True False 1028.5168744158505 952.8467622935311 950.6260418674902 984.4998716290808 1042.799277431015 1046.763516042384 1006.4860255631123 815.1212883688413 886.3219219869397 888.4930271203153 1.1575970131688764 1.072430208464091 1.0699307848802748 1.108055822137324 1.1736718754122584 1.178133630868255 1.1328012655599817 0.91742001736437 0.9975564184893917 1.0 9.795216643824496 -7.751491660717566 24.99964572772063 0.9681161628425005 1.1261571038959903 0.7518427101083957 0.04101326742571406 100.57582124824162 252759.04660703446 0.021399619950260105 0.012165886621672792 1.7721820740845228e-08 7.751491660717566 0.15804094105348987 SIS(ph)SPNVNR ddPTM_A459_Selumetinib_30min_R2 1 SISSPNVNR 9 0 Q9NQT8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 S(0.011)IS(0.495)S(0.495)PNVNR 97.597 0.02045 63087000.0 154670.0 166000.0 125470.0 217830.0 208660.0 135730.0 146270.0 173480.0 137120.0 182700.0 True False 146074.0605930671 178731.66622587244 117397.39680140694 188161.17822229097 182446.26535593235 154425.5754657352 153071.84482850652 173984.79807884007 164547.8314529112 177424.97628839198 0.8233004374515674 1.0073647462990585 0.6616734535197887 1.0605112209030145 1.028300914406654 0.8703711207757309 0.862741244387706 0.9806105189837527 0.927422028708349 1.0 17.436849587971345 -1.5228787452803376 0.1270413827211135 1.003428656505557 0.5590464794652424 0.08919537793912058 0.10923538631982364 261.0910076182783 2.2637830460179034 0.6387080239892426 20.69513523430328 0.029999999999999995 1.5228787452803376 -0.4443821770403146 SIS(ph)TSGPLDKEDTGR ddPTM_A459_Selumetinib_30min_R2 1 SISTSGPLDKEDTGR 15 1 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 S(0.076)IS(0.811)T(0.062)S(0.017)GPLDKEDT(0.034)GR 60.542 0.045738 6542900.0 74733.0 64276.0 72455.0 90329.0 82553.0 62424.0 68881.0 74082.0 55912.0 66589.0 True False 70579.63903990242 69205.76252008529 67793.32418303916 78026.03437378352 72181.95410681625 71022.339371348 72084.10298511216 74297.56635506461 67095.96231180828 64666.40255100025 1.0914421748486567 1.070196574882993 1.0483546557205314 1.2065930884626985 1.1162203440942726 1.098288084223257 1.114707176238261 1.1489361310375752 1.0375706652135461 1.0 15.980728733770219 -8.455248626281229 4.739285933379434 1.0005327629624567 1.1110020436969745 0.46299295257932405 0.04100260021405952 0.17502567309992398 7.229779952354785 0.04115439509270498 0.010728318265127252 3.5055113187448873e-09 8.455248626281229 0.11046928073451778 SISASKAS(ph)PPGDLQNPK ddPTM_A459_Selumetinib_30min_R1 2 SISASKASPPGDLQNPK 17 1 O00273 O00273 DFFA DNA fragmentation factor subunit alpha 1 SISAS(0.001)KAS(0.999)PPGDLQNPK;S(0.001)IS(0.025)AS(0.061)KAS(0.913)PPGDLQNPK 110.38 0.0011757 178165000.0 6893.799999999999 6952.799999999999 9010.6 10744.7 8159.0 7180.299999999999 7606.099999999999 7334.9 4027.1 5947.8 True False 7054.412127000283 6138.762943730975 7787.010011682923 8868.339847998821 7421.019890588442 7108.07270119077 7032.365753293761 7140.354624886983 6833.694572253269 6711.25806647814 1.051131107926866 0.9146963032748355 1.1602906540843696 1.3214124326845698 1.1057568964089564 1.0591267137669267 1.0478461241744692 1.0639368288565931 1.0182434507155498 1.0 12.712367518470774 -6.836040126387454 3.8896188647648815 1.04010850175268 1.1143517169489192 0.12876522456045003 0.09571731562735387 0.5950091527260769 17.583492246420906 0.03932630164123616 0.035113822614581895 1.4586794802021266e-07 6.836040126387454 0.07424321519623911 SISASKAS(ph)PPGDLQNPK ddPTM_A459_Selumetinib_30min_R2 1 SISASKASPPGDLQNPK 17 1 O00273 O00273 DFFA DNA fragmentation factor subunit alpha 1 SISAS(0.001)KAS(0.999)PPGDLQNPK 128.75 0.00054518 89977000.0 46651.0 48061.0 42699.0 51466.0 54175.0 30559.0 35410.0 31903.0 27630.0 49312.0 True False 44058.32417874945 51747.124159527935 39951.79282715607 44456.242016197975 47369.052169355076 34768.22486301777 37056.635163583866 31995.832448174016 33156.77204670308 47888.2344320372 0.9200239829529914 1.0805811651495998 0.8342715763274902 0.9283332856902483 0.989158458881608 0.7260285386457649 0.7738150216453376 0.6681355624747949 0.6923782519850267 1.0 15.547383626083919 -6.763845813869179 24.999682036440007 0.7514388957849774 0.9500162026105327 0.4205401557433216 0.10329688203585917 55.62823807812994 577898.53794255 0.03418749883465002 0.031575224885999884 1.7224799928089568e-07 6.763845813869179 0.1985773068255553 SISGASSGLST(ph)SPLSSPR ddPTM_A459_Selumetinib_30min_R2 1 SISGASSGLSTSPLSSPR 18 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 SISGASSGLS(0.002)T(0.865)S(0.133)PLSSPR 303.07 1.7749e-95 6090200.0 22932.0 21703.0 26921.0 26391.0 27961.0 17007.0 17815.0 22020.0 21411.0 24137.0 True False 21657.531244069418 23367.550313856056 25188.932169368563 22796.500272985693 24448.289205488432 19349.559875825234 18643.432799752813 22084.074554392755 25693.798273324643 23440.102094542523 0.9239520867578416 0.9969048009947296 1.074608466625801 0.9725427039967255 1.0430112081798757 0.8254895732868982 0.7953648292382437 0.9421492477003551 1.0961470291252204 1.0 14.51669123305404 -6.734161370792056 24.999897024223 0.9196852759055201 1.0042840981689982 0.13206087487400753 0.08739724538049505 411.45129806997494 377088.208157734 0.030491795493296826 0.03048474996794806 1.8443299941862016e-07 6.734161370792056 0.08459882226347815 SISGASSGLSTS(ph)PLSSPR ddPTM_A459_Selumetinib_30min_R1 2 SISGASSGLSTSPLSSPR 18 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 SISGASSGLS(0.001)T(0.02)S(0.966)PLS(0.013)SPR;SISGASS(0.001)GLS(0.108)T(0.214)S(0.675)PLS(0.001)SPR 191.15 2.3742e-10 16355200.0 5511.0 6113.1 6733.900000000001 7675.1 6749.9 6047.0 6646.099999999999 5953.0 3565.8999999999996 4965.1 True False 5639.395577460701 5397.37541009691 5819.4733666649945 6334.787864470454 6139.372736791633 5986.172670236709 6144.7793261941915 5795.107101930798 6051.071856968522 5602.418949169539 1.0066001183821933 0.9634008914840217 1.0387429821769452 1.130723696664898 1.0958432049609015 1.0684978621822017 1.096808250497769 1.0343937421512939 1.0800819988418553 1.0 12.451834156915918 -5.491592113297129 5.961938755322119 1.0763586108714254 0.9878082591218473 0.4898006416901932 0.0352007736592287 0.1402081733869214 15.262752986692682 0.009111634876842679 0.018398656716301722 3.2240954203289784e-06 5.491592113297129 -0.08855035174957804 SISGASSGLSTS(ph)PLSSPR ddPTM_A459_Selumetinib_30min_R2 2 SISGASSGLSTSPLSSPR 18 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 SISGASSGLS(0.002)T(0.419)S(0.577)PLS(0.001)SPR;SISGASSGLS(0.004)T(0.027)S(0.969)PLS(0.001)SPR 164.82 1.3708e-06 10475200.0 37991.0 39467.0 39137.0 42929.0 41258.0 34122.0 35605.0 35032.0 33379.0 37766.0 True False 35879.61231002274 42493.991993593365 36618.968029143725 37081.996143344426 36074.8011888002 38821.9957713241 37260.703049969066 35133.937320140205 40055.7326871843 36675.59745214787 0.9782966005349011 1.1586448468641033 0.9984559372733319 1.0110809017283713 0.9836186373205902 1.0585238814985012 1.0159535396412998 0.9579649620154346 1.0921630585417628 1.0 15.16253284740395 SISGT(ph)STSEKPNSMDTANTSPFK ddPTM_A459_Selumetinib_30min_R1 1 SISGTSTSEKPNSMDTANTSPFK 23 1 Q9UJF2-2;Q9UJF2 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.152)IS(0.212)GT(0.29)S(0.063)T(0.232)S(0.051)EKPNSMDTANTSPFK 83.167 0.00052082 22851000.0 1927.4 2080.9 1631.9 2109.2 1991.2 1603.8 2006.5 1842.0 1124.3 1729.2 True False 1972.3046699324536 1837.2672606158362 1410.2969433850521 1740.8678145875745 1811.0963115749132 1587.6672281338883 1855.1480895575814 1793.144176340758 1907.8549843769335 1951.1596638343574 1.010837148025366 0.9416283529587203 0.7227993533925261 0.8922221214672283 0.9282153301671909 0.8137044125921785 0.9507925588784994 0.9190145786516146 0.977805671027289 1.0 10.93011612349941 -8.053354730536721 1.2216677603045618 0.997841995693109 0.884001100192412 0.20994860016331673 0.07449961829012881 0.7439327377291675 2.0298168651015587 0.07083776571248734 0.02408588547246912 8.843929450139298e-09 8.053354730536721 -0.11384089550069709 SISLYYTGEK ddPTM_A459_Selumetinib_30min_R2 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 140.17 0.027451 0.0 29879.0 32904.0 35486.0 32080.0 33925.0 24815.0 25546.0 28653.0 24643.0 28852.0 False True 28218.444795113825 35427.63099696445 33202.86939423546 27710.648658913302 29663.03820665195 28233.041001858273 26733.939618438693 28736.375486240508 29572.28858294983 28018.967793501306 1.0071193558264764 1.2644159934107746 1.1850140104710247 0.9889960566406192 1.0586770513913066 1.0076402960285575 0.9541372050343461 1.0256043583770276 1.0554381874770133 1.0 14.774116188043859 -5.76083151668012 24.999995447480742 1.013230756889859 1.1634064315176271 0.4818680450467979 0.06586432848641083 12.5195376569845 514850.0602593648 0.017769693697486575 0.028565034990841724 1.7344767526153208e-06 5.76083151668012 0.15017567462776804 SISNEGLT(ph)LNNSHVSK ddPTM_A459_Selumetinib_30min_R2 1 SISNEGLTLNNSHVSK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 SIS(0.36)NEGLT(0.64)LNNSHVSK 234.36 2.0556e-15 12434000.0 13012.0 11330.0 20026.0 29847.0 33584.0 15070.0 14053.0 16819.0 16347.0 20895.0 True False 12288.845131163062 12198.974568308024 18737.548962660207 25781.78711105314 29364.877675230644 17145.755708160556 14706.492345491222 16867.940505464652 19616.856773342577 20291.70705827013 0.6056092321791425 0.6011803015526082 0.9234091990808379 1.270557821331521 1.4471368816288244 0.8449636917645426 0.7247538269333241 0.8312726207325134 0.9667425572925118 1.0 14.308602617778904 -5.317363755185652 4.247549932654913 1.0095665963362985 0.5988376956616929 0.3900093923684538 0.20086735076631476 0.23864209472898143 8.951706633407897 0.06160008520158104 0.14301589879033344 4.8154429811008245e-06 5.317363755185652 -0.41072890067460566 SISS(ph)PNVNR ddPTM_A459_Selumetinib_30min_R2 1 SISSPNVNR 9 0 Q9NQT8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 S(0.159)IS(0.244)S(0.596)PNVNR 93.442 0.024562 12768000.0 28901.0 22550.0 33738.0 34820.0 38435.0 28680.0 20023.0 28742.0 28852.0 28546.0 True False 27294.798119869636 24279.512490321784 31567.333811156976 30077.455932149664 33606.451686740395 32630.40966888152 20954.1091748218 28825.634461505753 34623.20619223587 27721.80280858478 0.9845967922193389 0.875827328329563 1.1387186478861082 1.0849747449626688 1.2122751149623385 1.1770666537883554 0.7558710852792305 1.0398181770696076 1.2489521850835001 1.0 14.758733461643333 -5.260459692895774 24.999551412532007 1.080108415018891 0.9302120562050653 0.17188530542738423 0.13338737245919446 157.40925668909716 4016615.1020388063 0.03621434689321165 0.08525686291124118 5.4895950246920374e-06 5.260459692895774 -0.1498963588138258 SISS(ph)PSVSSETMDKPVDLSTR ddPTM_A459_Selumetinib_30min_R2 1 SISSPSVSSETMDKPVDLSTR 21 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 S(0.005)IS(0.122)S(0.343)PS(0.057)VS(0.213)S(0.213)ET(0.046)MDKPVDLSTR 76.807 0.0015063 11301000.0 19719.0 16762.0 20581.0 24189.0 26319.0 18043.0 17612.0 18831.0 17619.0 21091.0 True False 18623.09692141134 18047.591501675113 19256.840866898514 20894.416471647557 23012.571925154687 20528.259471953603 18430.992897515942 18885.795092360127 21143.292315992097 20482.048029000984 0.9092399790803384 0.881141938351142 0.9401814134813241 1.0201331645186404 1.1235483821037173 1.002256192490477 0.8998608377159888 0.9220657556128817 1.032284090245997 1.0 14.3220723592212 -5.550629614506285 4.2138600491636335 0.9975020402106688 0.8972668473975092 0.3526879327511192 0.05774330515960006 0.2580285659350477 10.452764528609672 0.018067710869978555 0.034509695332811445 2.814299966377385e-06 5.550629614506285 -0.10023519281315962 SISS(ph)SNPDLAVAPGSVDDEVSR ddPTM_A459_Selumetinib_30min_R1 2 SISSSNPDLAVAPGSVDDEVSR 22 0 K7ESB7;K7EKT0;K7EP20;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 SISS(0.933)S(0.067)NPDLAVAPGSVDDEVSR;SIS(0.001)S(0.499)S(0.499)NPDLAVAPGSVDDEVSR 474.11 0.0 44165000.0 3668.2000000000003 4094.7999999999997 4975.6 4888.8 4642.7 3633.3 3967.4 3924.0 1900.0 3327.3 True False 3753.6619229253006 3615.3789123791253 4299.9408490144415 4035.062854141725 4222.768604735259 3596.752300772453 3668.1358238279363 3819.922773051646 3224.1612294905053 3754.3913656465743 0.9998057094612064 0.9629733717855201 1.1453097000914059 1.0747581861239481 1.1247545057168065 0.9580120851766947 0.9770254261162293 1.0174546020973458 0.8587706809130823 1.0 11.874363332233061 -6.784911162471461 24.922480173431445 0.9642667299515836 1.0614358737069902 0.3800544423549368 0.06336547946636528 263.57806697283723 279866.59688812133 0.02307798636599199 0.020364722292510497 1.6409253999562405e-07 6.784911162471461 0.09716914375540664 SISS(ph)SNPDLAVAPGSVDDEVSR ddPTM_A459_Selumetinib_30min_R2 1 SISSSNPDLAVAPGSVDDEVSR 22 0 K7ESB7;K7EKT0;K7EP20;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 SIS(0.087)S(0.457)S(0.457)NPDLAVAPGSVDDEVSR 246.32 2.8343e-44 13301000.0 24686.0 17201.0 21410.0 20607.0 20704.0 16351.0 14237.0 14177.0 16607.0 15840.0 True False 23314.05094588776 18520.26139006763 20032.503909445455 17800.291050942218 18102.978423891593 18603.201830400336 14899.048710080308 14218.252722871306 19928.864038349562 15382.658042737447 1.515606137841368 1.203970168134338 1.3022784393821536 1.1571661413448764 1.1768433240598806 1.2093619827415583 0.9685613935307192 0.9243040236199045 1.295540990574025 1.0 13.909017194536105 -1.522878745315338 0.329633914869621 1.0426378015694049 5.337253888457283 0.5459591136060279 0.11378936449647951 45.420125316313616 0.6466638658264966 0.10302584754022463 118.7896829430509 0.029999999997582252 1.522878745315338 4.294616086887879 SISSPS(ph)VSSETMDKPVDLSTR ddPTM_A459_Selumetinib_30min_R1 1 SISSPSVSSETMDKPVDLSTR 21 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 SISS(0.002)PS(0.994)VS(0.003)S(0.001)ETMDKPVDLSTR 195.25 1.0034e-16 30721000.0 2691.6 2869.9 2786.8 3213.7 2803.2 2338.3 3239.5 2843.1 1683.9 2406.1 True False 2754.3090430581046 2533.8907738196854 2408.3678667966574 2652.487623620369 2549.651054945158 2314.778825006532 2995.141906863588 2767.691752309667 2857.4553128100324 2714.946372398709 1.0144985076167887 0.933311537782215 0.8870775096263932 0.9769944815804386 0.9391165442035935 0.8526057267795601 1.1032048136616859 1.0194277796597346 1.0524905176249997 1.0 11.40670798580828 -7.268900526496994 24.988378464332413 1.045399757825524 0.9339687720351234 0.5539565444237006 0.04827971769757693 443.40381280523053 1485012.5791106562 0.019671253494115346 0.01355712901337233 5.383930852878081e-08 7.268900526496994 -0.11143098579040067 SISSPSVSS(ph)ETMDKPVDLSTR ddPTM_A459_Selumetinib_30min_R1 1 SISSPSVSSETMDKPVDLSTR 21 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 SIS(0.01)S(0.055)PS(0.357)VS(0.087)S(0.49)ETMDKPVDLSTR 110.34 6.0477e-05 24884000.0 1024.2 1456.2 1178.2 1374.0 1308.6 1317.0 1519.8 1293.9 794.51 997.26 True False 1048.0618672537196 1285.7074270309865 1018.2069113893425 1134.0566931743438 1190.237361052095 1303.7521757403242 1405.1602624020009 1259.5815688204693 1348.2254412855261 1125.2680351350052 0.9313886421095906 1.142578822899499 0.9048572247652819 1.007810279653313 1.0577367559448136 1.158614778908125 1.2487338292102248 1.119361369461943 1.1981371541614718 1.0 10.136052972239426 -6.605896575155987 3.0241865369688985 1.1592678971153003 1.0021189040807308 0.40411721474837703 0.08415352639874588 0.24205699910162376 4.470175637954922 0.028240672085121613 0.028597479262349956 2.478012112336924e-07 6.605896575155987 -0.15714899303456953 SISSPSVSS(ph)ETMDKPVDLSTR ddPTM_A459_Selumetinib_30min_R2 1 SISSPSVSSETMDKPVDLSTR 21 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 S(0.001)IS(0.024)S(0.109)PS(0.327)VS(0.074)S(0.464)ET(0.001)MDKPVDLSTR 130.95 2.8174e-05 11158000.0 30725.0 26299.0 30290.0 31776.0 34783.0 29099.0 32244.0 27698.0 26350.0 32093.0 True False 29017.427501920174 28316.048735386805 28341.174377258416 27448.053983342536 30413.248576034635 33107.12311557819 33743.40989027388 27778.59659434924 31620.73628051488 31166.39170237201 0.9310486686757428 0.9085443385873806 0.9093505160272187 0.8806939938848782 0.9758347667086513 1.0622700064781152 1.082685805033559 0.891299732725719 1.014578029515951 1.0 14.927703515763085 -6.4396497309429455 4.961386863829162 1.0090633887758333 0.9084430891514419 0.4988605243122822 0.04857526791460217 0.2046383528367303 8.701091048277622 0.016268177148891182 0.018298793528537454 3.6337100416697586e-07 6.4396497309429455 -0.10062029962439145 SISSS(ph)NPDLAVAPGSVDDEVSR ddPTM_A459_Selumetinib_30min_R2 1 SISSSNPDLAVAPGSVDDEVSR 22 0 K7ESB7;K7EKT0;K7EP20;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 SIS(0.002)S(0.231)S(0.767)NPDLAVAPGSVDDEVSR 226.72 2.6193e-30 13833000.0 30235.0 24768.0 25053.0 32083.0 30236.0 21485.0 27760.0 28181.0 21515.0 24894.0 True False 28554.65974029475 26667.625958327713 23441.117255643967 27713.240053737987 26437.483366730412 24444.36372858855 29050.89500539647 28263.002044384288 25818.60117932742 24175.245537620332 1.1811528323821732 1.1030963849706867 0.9696330578800554 1.1463478213949059 1.0935766226485557 1.0111319734291604 1.2016794187338817 1.169088520751642 1.0679767921756897 1.0 14.56124292216194 -7.256307883705052 24.992235715939433 1.123776891363239 1.0830668213675034 0.012822632064692585 0.07663886222049858 1401.3876538258808 6825278.586877926 0.02971481290231593 0.022327524473507207 5.542326623610249e-08 7.256307883705052 -0.040710069995735676 SIT(ph)SPTTLYDR ddPTM_A459_Selumetinib_30min_R2 1 SITSPTTLYDR 11 0 Q08999;F5H837 Q08999 RBL2 Retinoblastoma-like protein 2 1 SIT(0.601)S(0.33)PT(0.008)T(0.06)LYDR 181.31 0.00010018 22815000.0 45426.0 42973.0 49773.0 52104.0 51519.0 47063.0 40165.0 38658.0 36852.0 51495.0 True False 42901.40477468592 46268.89092002653 46570.65936874494 45007.3453155866 45046.7226342963 53545.501054622415 42032.75208543764 38770.48837982359 44223.42973091212 50008.20554992203 0.857887306751258 0.9252259786413927 0.931260357307853 0.8999992065433504 0.9007866236937296 1.0707343018171125 0.8405171036076734 0.7752825352055457 0.884323467411061 1.0 15.609877217134908 -10.528356613215534 4.694802837716657 1.0000021412995286 0.9000546102844683 0.15144100698045826 0.07202626480148004 1.7150226079715204e-06 3.6321495620302825e-07 0.07409070920158613 0.01796925155908905 2.962397870040707e-11 10.528356613215534 -0.09994753101506026 SITNNSSDPFLNGGPYHS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SITNNSSDPFLNGGPYHSR 19 0 Q9GZV5;C9J337 Q9GZV5 WWTR1 WW domain-containing transcription regulator protein 1 1 SITNNSSDPFLNGGPY(0.096)HS(0.904)R 83.73299999999998 0.0028885 10365000.0 57913.0 41529.0 58093.0 53597.0 53250.0 40462.0 61320.0 59392.0 46894.0 45370.0 True False 54694.42730410748 44714.14076321834 54355.359626876016 46296.996140017916 46560.258938959945 46035.27322253432 64171.50150327484 59564.820887125126 56274.110327835464 44060.050214583214 1.241360984332343 1.0148454335718988 1.2336654035152508 1.0507703898325178 1.056745480592966 1.0448302486795018 1.456455478165457 1.3519008852016712 1.2772139399244167 1.0 15.42718351880724 -7.24261655877873 24.828950585057868 1.3007176670377116 1.103758200940251 0.26503576327054756 0.1304085318711686 815.7314620419404 1076022.723496631 0.04745981678192364 0.03669897689708628 5.71983421417953e-08 7.24261655877873 -0.19695946609746073 SITS(ph)PTTLYDR ddPTM_A459_Selumetinib_30min_R1 2 SITSPTTLYDR 11 0 Q08999;F5H837 Q08999 RBL2 Retinoblastoma-like protein 2 1 SIT(0.002)S(0.562)PT(0.337)T(0.099)LYDR;SIT(0.003)S(0.909)PT(0.081)T(0.008)LYDR 157.03 0.00055491 48670000.0 4536.5 5167.6 4915.2 5437.6 5119.7 4509.8 4824.1 4865.9 2746.0 3474.9 True False 4642.191623507615 4562.57498964794 4247.742837260991 4488.025236393603 4656.624038956447 4464.435506570775 4460.2142530948095 4736.840525329256 4659.7614400952225 3920.9372633923253 1.1839494772969852 1.163643966519495 1.0833488403193474 1.1446307183478481 1.1876303358466946 1.138614368623747 1.1375377756582392 1.208088833645613 1.1884305019620944 1.0 11.936982842987677 -10.55573557742987 4.772957485408393 0.9999961765826207 1.157974096873164 0.6643092521608358 0.03400714151989003 1.475921495267066e-06 2.990397037060946e-07 0.03512373249233052 0.00851855027962383 2.7814062267138445e-11 10.55573557742987 0.15797792029054325 SITS(ph)PTTLYDR ddPTM_A459_Selumetinib_30min_R2 2 SITSPTTLYDR 11 0 Q08999;F5H837 Q08999 RBL2 Retinoblastoma-like protein 2 1 S(0.003)IT(0.02)S(0.943)PT(0.027)T(0.007)LYDR;SIT(0.08)S(0.917)PT(0.003)T(0.001)LYDR 161.93 0.00061866 27259100.0 102572.0 82087.0 117643.0 127202.0 134317.0 89294.0 84806.0 98235.0 85542.0 110878.0 True False 96871.45886824917 88382.80894869367 110073.97746001356 109876.86816431051 117442.89765078474 101593.43796977345 88749.64703990109 98520.84758632028 102652.79024318019 107676.6640443588 0.8996513750494882 0.8208167455139883 1.0222640015543865 1.0204334350388615 1.0906996301668728 0.9435046940897122 0.8242235941052141 0.914969352558446 0.9533429657598887 1.0 16.716346093721192 -5.256596348014939 24.994595466914863 0.9679337047675761 0.8602340574513052 0.2850594808699377 0.07013035189224755 595.7695640028054 3074707.6690429435 0.020448544484763846 0.05056338174216108 5.538646557091882e-06 5.256596348014939 -0.10769964731627091 SITST(ph)PLSGK ddPTM_A459_Selumetinib_30min_R2 1 SITSTPLSGK 10 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 SITS(0.028)T(0.868)PLS(0.103)GK 101.35 0.023857 0.0 142960.0 137160.0 155700.0 164610.0 140940.0 154130.0 209810.0 259990.0 304410.0 446600.0 True False 135014.85551422328 147679.73096108777 145682.4315133424 142189.83403191136 123233.8571804136 175360.00844716563 219566.58073062796 260746.52785633827 365300.5059260551 433705.497593848 0.3113053817931093 0.3405069379576677 0.3359017405164865 0.32784881635295254 0.28414179175523935 0.40432968781821843 0.5062573150415662 0.6012064161116987 0.8422777851622898 1.0 18.726356205166333 -8.066266875804882 0.9251276033860089 1.0043306161537637 0.3195846190914349 0.9868560814329193 0.026901208688610175 0.055913151920798966 0.09288798497352249 0.02612230249449867 0.009804515700481888 8.584858162008041e-09 8.066266875804882 -0.6847459970623289 down SITSTPLS(ph)GK ddPTM_A459_Selumetinib_30min_R1 1 SITSTPLSGK 10 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 SIT(0.006)S(0.139)T(0.139)PLS(0.716)GK 86.772 0.034589 12607000.0 3087.7 4182.3 4604.1 5085.4 4200.7 4124.9 5096.9 5105.6 3025.2 3315.6 True False 3159.6374023816743 3692.634371701481 3978.88850851101 4197.330354780792 3820.747426693822 4083.407251109541 4712.436729462267 4970.182902673926 5133.54344813404 3741.189556678924 0.8445542131755823 0.9870214582175447 1.0635356611128501 1.1219240006931877 1.021265394016956 1.0914729631434141 1.2596091852788995 1.328503361664996 1.372168763533895 1.0 11.869281350137154 -7.1338040740239 2.5966922954072946 1.2706621074233049 1.0160386436601607 0.47019709413610056 0.11440680765768543 0.24326889134416463 3.191396975736262 0.049708605687264984 0.03643668732955054 7.348453087326765e-08 7.1338040740239 -0.25462346376314415 SITSTPLS(ph)GK ddPTM_A459_Selumetinib_30min_R2 3 SITSTPLSGK 10 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 SITSTPLS(1)GK;SITSTPLS(1)GK;SITSTPLS(1)GK 126.34 0.0034724000000000005 36138300.0 212649.0 199284.0 231053.0 200679.0 184905.0 139505.0 195365.0 263932.0 228405.0 274268.0 True False 200830.81988139384 214568.44200094359 216187.3015314851 173346.17400941552 161675.5808283265 158720.54744969733 204449.85960840347 264699.9984237053 274092.3821689183 266349.17020615644 0.7540133116463218 0.8055908033611138 0.8116687630907743 0.6508230300670513 0.6070061367309245 0.5959115522186397 0.7676008881505341 0.9938082338263916 1.0290716579171941 1.0 18.022959260718537 -7.720896246492122 3.8144167318802853 1.014832395863687 0.7052339111088891 0.7903390909255201 0.07011748027756878 0.11276256009112973 3.4160713164986434 0.04456666608203117 0.022703576699023616 1.901532504214091e-08 7.720896246492122 -0.3095984847547978 SIVECQPDASATPGVGT(ph)ADSPAAPTDSRDDQK ddPTM_A459_Selumetinib_30min_R1 1 SIVECQPDASATPGVGTADSPAAPTDSRDDQK 32 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 SIVECQPDASATPGVGT(0.693)ADS(0.306)PAAPT(0.001)DSRDDQK 120.4 1.2978e-16 9292200.0 845.2 882.06 1060.8 1172.3 827.54 763.89 581.65 751.55 414.88 710.94 True False 864.8915155270887 778.7880051414305 916.7491865573039 967.5798117964217 752.689153114053 756.205960156626 537.775672210898 731.6164526215503 704.0210583636951 802.1960741420304 1.0781547596728303 0.9708200155110016 1.1427993929511449 1.2061637335127493 0.9382857600232882 0.9426697344105155 0.6703793368548495 0.9120169946032622 0.8776171824533846 1.0 9.647811095556063 -6.549283115643976 2.9046888094963492 0.8611716682414856 1.0925845912272822 0.5144055772254992 0.0989181701625326 0.21131117147783998 3.6408335680720265 0.03491072178917026 0.03660324162027492 2.823039041816682e-07 6.549283115643976 0.23141292298579663 SIVECQPDASATPGVGTADS(ph)PAAPTDSRDDQK ddPTM_A459_Selumetinib_30min_R2 2 SIVECQPDASATPGVGTADSPAAPTDSRDDQK 32 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 SIVECQPDASATPGVGT(0.072)ADS(0.927)PAAPT(0.001)DSRDDQK;SIVECQPDASAT(0.001)PGVGT(0.144)ADS(0.855)PAAPTDSRDDQK 120.13 5.4683999999999997e-17 12402900.0 32740.0 35467.0 41350.0 43925.0 37245.0 29412.0 26920.0 31031.0 22780.1 42966.0 True False 30920.441868604277 38187.204855620505 38689.58601847592 37942.33922514858 32565.950125475396 33463.2360244471 28171.833340968045 31121.29507254142 27336.75652917483 41725.45994092532 0.7410449618142322 0.915201531862938 0.9272416906428935 0.9093330374037132 0.7804815134831848 0.8019860313540981 0.6751713074188654 0.7458586464140307 0.6551577039025588 1.0 15.348640332093222 -6.407224278200717 3.566194231695491 0.7558351420290728 0.8797668918181917 0.1638570366311085 0.10119591728443313 0.35452343612992543 8.220092733938975 0.03174006668731744 0.03600840751376228 3.915396261356682e-07 6.407224278200717 0.12393174978911892 SIVPSS(ph)PQPQR ddPTM_A459_Selumetinib_30min_R2 2 SIVPSSPQPQR 11 0 H7C5K2;H7C5C6;H7C5A5;A0A1X7SBY3;H0Y860;Q9P246-3;Q9P246;Q9P246-2 H7C5K2 STIM2 Stromal interaction molecule 2 1 S(0.001)IVPS(0.1)S(0.899)PQPQR;SIVPS(0.207)S(0.793)PQPQR 145.83 0.00069482 14650200.0 116155.0 46459.0 94434.0 100559.0 64484.0 54127.0 138816.0 102445.0 101026.0 68385.0 True False 109699.57010530631 50022.25591076981 88358.21925196513 86862.69072604926 56382.94342572576 61582.50293401497 145271.21905868576 102743.09798931725 121234.02290228828 66410.5473644317 1.6518395715566627 0.7532275804966613 1.3304847310939079 1.3079652882453332 0.8490058531865596 0.927300035581358 2.1874720932731 1.5470900642560375 1.825523621074972 1.0 16.019124769042413 -7.24023075556488 24.9974197813118 1.685612361538613 1.122734198797316 0.3044452971983128 0.36983395598445334 869.8720223081953 1025270.8661810977 0.13413261942954283 0.1037980748098708 5.7513426756076674e-08 7.24023075556488 -0.5628781627412969 SIYDDIS(ph)SPGLGSTPLTSR ddPTM_A459_Selumetinib_30min_R2 1 SIYDDISSPGLGSTPLTSR 19 0 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 SIYDDIS(0.453)S(0.453)PGLGS(0.043)T(0.043)PLT(0.007)S(0.002)R 67.952 0.019961000000000003 4826600.0 14406.0 17137.0 19081.0 26378.0 25466.0 16890.0 18594.0 17962.0 17493.0 21714.0 True False 13605.372191787206 18451.352795860068 17853.349233821988 22785.27089541194 22266.73341107146 19216.444187845485 19458.65784331202 18014.26644623083 20992.088795257947 21087.06040025259 0.6452000389596377 0.8750082963502608 0.8466495042432814 1.080533296861947 1.055942980596989 0.9112908021838503 0.9227771663744527 0.8542805921879489 0.9954962141146281 1.0 14.364070372662828 -4.544892156800284 1.3349969173732446 0.9614045968304121 0.3579425214790345 0.6400269177697316 0.07191147121587657 1.564356226545197 1.6590603547982492 0.022534316597083288 1.4904301005535046 2.8517263149756195e-05 4.544892156800284 -0.6034620753513776 SIYDDISSPGLGS(ph)TPLTSR ddPTM_A459_Selumetinib_30min_R1 1 SIYDDISSPGLGSTPLTSR 19 0 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 SIYDDISSPGLGS(0.783)T(0.182)PLT(0.017)S(0.017)R 64.275 0.017102000000000003 3275100.0 2011.4 2093.6 2781.7 3423.7 2604.6 2489.8 2269.5 2094.3 1286.7 1643.4 True False 2058.261706496906 1848.480338711765 2403.960418784363 2825.8150658085897 2369.01438987948 2464.7548725575252 2098.309787815068 2038.7523607548585 2183.435923150228 1854.3463980715849 1.1099661361207276 0.996836589233856 1.2963923144480154 1.5238873754910502 1.2775468447228202 1.3291771565014663 1.1315630078593681 1.099445261616193 1.177469282665244 1.0 10.856695054030041 -7.393680140861891 5.7773132402683895 1.1062063830114224 1.2585404225937076 0.2361326544493425 0.13574964301186826 0.42219717563922626 18.047765113914924 0.06515826707116842 0.04333906695686051 4.039427884662214e-08 7.393680140861891 0.1523340395822852 SIYDDISSPGLGST(ph)PLTSR ddPTM_A459_Selumetinib_30min_R2 2 SIYDDISSPGLGSTPLTSR 19 0 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 SIYDDIS(0.004)S(0.018)PGLGS(0.237)T(0.739)PLT(0.001)SR;SIYDDISS(0.001)PGLGS(0.035)T(0.964)PLTSR 246.49 4.0973e-37 11991200.0 62056.0 53286.0 56295.0 67533.0 66092.0 62607.0 54960.0 54385.0 42557.0 52277.0 True False 58607.17594985051 57372.86485850496 52673.04098936161 58334.88889907703 57788.93209002327 71230.54596023937 57515.74890117398 54543.251346078585 51069.589141930635 50767.627178042036 1.154420232096237 1.1301072759870845 1.0375320635852703 1.149056832900553 1.1383027985010512 1.4030702224950142 1.1329217475432973 1.0743707038896153 1.0059479235227917 1.0 15.63162121124452 -7.919610263746258 2.7565656032954795 1.0083711159099078 1.1654444320568238 0.36122686808216264 0.08718109730878496 0.3424757822718835 5.078764303115907 0.06705068124293051 0.026064777967169467 1.2033438320423925e-08 7.919610263746258 0.157073316146916 SIYGEKFEDENFILK ddPTM_A459_Selumetinib_30min_R1 2 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 ; 173.06 9.8222e-05 102734000.0 8495.9 8773.1 12963.3 13698.599999999999 10216.0 9436.5 9323.8 8752.6 5169.0 6381.4 False True 8693.837939856348 7745.941373496464 11202.955062309846 11306.396664569185 9291.96460378129 9341.577377656464 8620.498259365557 8520.45261554838 8771.41547117706 7200.514850099799 1.207391154777752 1.0757482672769023 1.5558547264373148 1.5702205883809097 1.2904583626617343 1.2973485330048293 1.197205816365489 1.1833115815920143 1.2181650414977603 1.0 12.813884350262922 -8.228191326168727 0.685306286922136 1.0183663224212594 1.343171267759304 0.3254051939721816 0.1427280818795107 0.9002139831918264 0.9513975562569625 0.15428973321632505 0.06652836116713755 5.9130108217974324e-09 8.228191326168727 0.3248049453380446 SIYYITGESK ddPTM_A459_Selumetinib_30min_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 145.89 0.012243 9008800.0 3195.0 3661.9 3469.8 3577.7 3286.8 3006.2 3253.1 2942.0 2078.9 2484.7 False True 3269.4372836122184 3233.163045628875 2998.6202182471065 2952.921856746614 2989.509520331672 2975.960357411209 3007.716047914163 2863.96860303719 3527.7414631514785 2803.635448027545 1.1661420838120666 1.1532037975563183 1.0695471197429538 1.0532474394358573 1.0662975182579089 1.0614648061697538 1.0727914180248348 1.0215196148458214 1.258273954851501 1.0 11.453083055011088 -5.232841880915859 5.597516726401932 1.0743639468922415 1.1613201982048067 0.20956879677591733 0.06550687174455652 0.2711605078726107 26.513840477263187 0.016022220255619606 0.0419195087960664 5.850030348291783e-06 5.232841880915859 0.08695625131256524 SIYYITGESK ddPTM_A459_Selumetinib_30min_R2 2 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 ; 150.61 0.009745299999999998 22688000.0 175790.0 182434.0 183223.0 204308.0 200204.0 147715.0 149815.0 169930.0 155411.0 173743.0 False True 166020.2955431259 196426.1011822339 171434.63165811854 176480.89794904192 175052.5836735311 168061.40042673756 156781.69435279083 170424.4681665742 186497.54254615144 168726.58815147265 0.9839604851968131 1.164168038566004 1.0160498919365024 1.0459578415146278 1.0374925824753793 0.9960575998600889 0.9292056223648735 1.0100629072969656 1.1053239716951135 1.0 17.364327807705557 -6.083364646675235 1.4195140866650702 1.0063176943606174 1.0678788238580523 0.10221531787036897 0.05909269039417362 0.8271578333471645 3.3625364143017484 0.021554830597822233 0.03540270781761102 8.253446744227644e-07 6.083364646675235 0.061561129497434974 SKDDQVTVIGAGVTLHEALAAAELLK ddPTM_A459_Selumetinib_30min_R1 1 SKDDQVTVIGAGVTLHEALAAAELLK 26 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 86.91799999999998 6.0105e-05 2079500.0 1348.8 1624.0 1073.0 938.41 1127.9 1004.7 1179.2 1029.8 812.21 992.55 False True 1380.224415692068 1433.861325022883 927.2924935671066 774.5343096373623 1025.8816441469185 994.5936301946115 1090.251994620633 1002.486358738171 1378.2610485286743 1119.95346075572 1.2323944378552327 1.2802865255270026 0.8279741311227253 0.6915772277847363 0.9160038163145422 0.888066928712807 0.9734797318139942 0.8951143006082728 1.230641358613825 1.0 10.12922306754145 -5.254862753257528 24.90784363333827 0.9154576589385713 1.2563405268350682 0.5021535382219684 0.130361726195089 392.5632611166194 1486755.4517237854 0.03450300792012325 0.08681698602413963 5.560799631762189e-06 5.254862753257528 0.3408828678964969 SKDHFGLEGDEESTMLEDS(ph)VSPK ddPTM_A459_Selumetinib_30min_R1 1 SKDHFGLEGDEESTMLEDSVSPK 23 1 Q9Y490 Q9Y490 TLN1 Talin-1 1 SKDHFGLEGDEES(0.001)T(0.006)MLEDS(0.622)VS(0.371)PK 58.12300000000001 0.0088355 10748000.0 3108.4 3358.1 3913.6 4286.6 3118.7 3275.6 3266.9 2739.6 1063.8 2383.0 True False 3180.8196721064865 2964.9320908616633 3382.154615866008 3538.025779447703 2836.614135651205 3242.6504380068372 3020.475102803722 2666.9369085250487 1805.1909031221041 2688.8812623856543 1.1829528200454527 1.102663822437101 1.2578296643955418 1.3157984433677308 1.054942133493272 1.2059477982043219 1.123320373069902 0.991838853515928 0.6713538929273827 1.0 11.39279033368114 -7.880114874289776 2.778671724248082 0.833269767286688 1.1828860567005017 0.6442760085743728 0.10273968814990381 0.15802415928789226 2.3900559837999604 0.06760820857210935 0.027383570892325192 1.3179080954422389e-08 7.880114874289776 0.34961628941381373 SKDHFGLEGDEESTMLEDSVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 SKDHFGLEGDEESTMLEDSVSPK 23 1 Q9Y490 Q9Y490 TLN1 Talin-1 1 SKDHFGLEGDEES(0.034)T(0.027)MLEDS(0.05)VS(0.889)PK;SKDHFGLEGDEESTMLEDS(0.136)VS(0.864)PK;SKDHFGLEGDEESTMLEDS(0.291)VS(0.709)PK 86.527 0.0001388 34991900.0 4344.17 5173.1 5476.9 5800.9 5580.2 4704.18 4919.5599999999995 4532.110000000001 1873.11 3942.0899999999997 True False 4445.380708716651 4567.431047091056 4733.167062458236 4787.881711379221 5075.47189526433 4656.8602202536995 4548.473628439522 4411.903720431981 3178.530863458399 4448.095650708294 0.9993896394761181 1.0268284240613754 1.0640884176365561 1.076389108362996 1.1410437845364534 1.0469334712962306 1.022566506121613 0.9918634999967796 0.7145823995381629 1.0 12.118972096401295 -8.04671060276071 6.258887213008306 0.8535241040485915 1.0541343870973143 0.5286439417886162 0.07333512306549142 0.15551974805882524 15.124584095510645 0.047449990044482276 0.018109237462724206 8.98027006030443e-09 8.04671060276071 0.20061028304872286 SKDHFGLEGDEESTMLEDSVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SKDHFGLEGDEESTMLEDSVSPK 23 1 Q9Y490 Q9Y490 TLN1 Talin-1 1 SKDHFGLEGDEESTMLEDS(0.012)VS(0.988)PK;SKDHFGLEGDEESTMLEDS(0.089)VS(0.911)PK 93.179 4.7134e-05 31412000.0 156033.0 154229.0 204333.0 223375.0 211920.0 173206.0 184884.0 172786.0 134767.0 215457.0 True False 147361.31050958842 166057.86837560224 191186.43724094867 192950.9396566323 185296.71501116245 197063.55429247892 193481.4723406959 173288.7786537379 161724.16570459775 209236.19658548466 0.704282112341796 0.7936383431045514 0.913735005514872 0.9221680703692254 0.8855863279633761 0.9418234392918123 0.9247036387494643 0.828196944322393 0.7729263308345619 1.0 17.67477292505221 -5.004297998301118 2.7789064888745716 0.8952325253306765 0.7033843361351915 0.529212083553275 0.05917368870103692 0.24689116948176082 3.47597642993414 0.016069663856496306 0.08600219664546663 9.90152302459246e-06 5.004297998301118 -0.19184818919548507 SKDHFGLEGDEESTMLEDSVS(ph)PKK ddPTM_A459_Selumetinib_30min_R1 1 SKDHFGLEGDEESTMLEDSVSPKK 24 2 Q9Y490 Q9Y490 TLN1 Talin-1 1 SKDHFGLEGDEES(0.013)T(0.013)MLEDS(0.284)VS(0.691)PKK 43.835 0.031426 13821000.0 1929.6 1886.8 2505.6 2185.7 2262.7 2199.4 1738.6 1620.8 615.8 919.88 True False 1974.5559256519987 1665.8925788504764 2165.3532822756206 1804.0085256704242 2058.0391845121303 2177.27603289542 1607.4560022451087 1577.811118899619 1044.967623747502 1037.9555583899769 1.902351126395843 1.6049748617701156 2.086171478896847 1.7380402379353401 1.9827816016559077 2.097658242972077 1.5486751713517595 1.5201143306627098 1.0067556508569615 1.0 10.019528958547694 -7.9719018014095635 1.4991302961704076 0.9760957735352062 1.885928721571734 0.817448372431165 0.1620343948123599 0.16413895260015215 0.6630143823666571 0.14066881276090193 0.04773995143354648 1.0668373171978338e-08 7.9719018014095635 0.9098329480365278 SKDYDVYS(ph)DNDICSQESEDNFAK ddPTM_A459_Selumetinib_30min_R1 4 SKDYDVYSDNDICSQESEDNFAK 23 1 A0A0C4DGZ1;Q8N5P1 A0A0C4DGZ1 ZC3H8 Zinc finger CCCH domain-containing protein 8 1 SKDY(0.001)DVY(0.028)S(0.97)DNDICS(0.001)QESEDNFAK;SKDYDVY(0.005)S(0.994)DNDICSQESEDNFAK;SKDY(0.011)DVY(0.217)S(0.768)DNDICS(0.003)QESEDNFAK;SKDYDVY(0.028)S(0.971)DNDICSQESEDNFAK 142.85 7.6287e-07 126850000.0 12878.1 14414.7 17622.3 17644.0 13515.2 13944.2 13576.4 13288.5 7469.900000000001 11553.1 True False 13178.134673579494 12727.02022278778 15229.288452364977 14562.806618899658 12292.752546302356 13803.934008320604 12552.321217577657 12936.045812868706 12675.874720090063 13036.05292172375 1.010899138927165 0.9762939978234525 1.168243834526503 1.1171177891301491 0.9429811784376287 1.0589044161762513 0.9628927784314234 0.9923284210753403 0.9723706091255986 1.0 13.670219493577582 -6.261988568881146 24.999980218418177 0.9901278917885352 1.0687287217240733 0.3217405701971393 0.05678520841298005 66.37030367788235 3021307.4658907177 0.018276363024757433 0.02202840208876726 5.470303611583775e-07 6.261988568881146 0.07860082993553807 SKDYDVYS(ph)DNDICSQESEDNFAK ddPTM_A459_Selumetinib_30min_R2 4 SKDYDVYSDNDICSQESEDNFAK 23 1 A0A0C4DGZ1;Q8N5P1 A0A0C4DGZ1 ZC3H8 Zinc finger CCCH domain-containing protein 8 1 S(0.002)KDY(0.006)DVY(0.163)S(0.815)DNDICS(0.014)QESEDNFAK;S(0.001)KDY(0.001)DVY(0.064)S(0.701)DNDICS(0.23)QES(0.003)EDNFAK;S(0.011)KDY(0.022)DVY(0.083)S(0.744)DNDICS(0.138)QES(0.002)EDNFAK;S(0.002)KDY(0.003)DVY(0.034)S(0.958)DNDICS(0.003)QESEDNFAK 96.708 3.8585e-05 101742000.0 392874.0 378319.0 404451.0 396708.0 404187.0 323406.0 347966.0 359066.0 279660.0 403156.0 True False 371039.63587923173 407334.8508126846 378429.0629929537 342675.68604052893 353409.41558237356 367952.24091263214 364147.10848154826 360110.8226134236 335599.81435327436 391515.83875491435 0.9477001928177405 1.0404045264377486 0.9665740834302419 0.8752536988804712 0.902669523425347 0.9398144455222593 0.9300954710787609 0.9197860902859921 0.8571806837254342 1.0 18.57871114729401 -5.554604591284184 7.673220988795664 0.9155405559564621 0.9964563306628151 0.3617901211590654 0.04178370113861896 0.17699834391820496 34.823309195066614 0.010774216838568195 0.01894511653332875 2.7886589817955133e-06 5.554604591284184 0.08091577470635303 SKEFVS(ph)SDESSSGENK ddPTM_A459_Selumetinib_30min_R1 1 SKEFVSSDESSSGENK 16 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 S(0.004)KEFVS(0.876)S(0.068)DES(0.026)S(0.026)SGENK 118.05 0.008513799999999998 9991100.0 1809.0 2160.8 2054.5 2009.6 1836.5 1589.3 1747.0 1461.2 1366.2 1812.0 True False 1851.1461802987478 1907.8125314713336 1775.5101845606896 1658.6610848640184 1670.3888992604097 1573.3130849689428 1615.2223834822314 1422.444229353482 2318.3416166999627 2044.5878503746562 0.9053884282641798 0.9331037211835825 0.8683951556473056 0.8112447134810473 0.8169807420866376 0.7695013372404831 0.7899990128505622 0.6957119641950474 1.1338919070047018 1.0 10.997594337537103 -8.27066402729464 24.999990139317184 1.0669459769284164 0.8253399958575328 0.6529197887306935 0.0709062680619228 480.9330288861406 1303375.5276110102 0.06972697413909977 0.019026924248687658 5.3621131325403414e-09 8.27066402729464 -0.2416059810708836 SKEFVS(ph)SDESSSGENK ddPTM_A459_Selumetinib_30min_R2 3 SKEFVSSDESSSGENK 16 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 SKEFVS(0.67)S(0.31)DES(0.012)S(0.005)S(0.002)GENK;SKEFVS(0.403)S(0.194)DES(0.337)S(0.056)S(0.009)GENK;S(0.014)KEFVS(0.488)S(0.488)DES(0.007)S(0.003)S(0.001)GENK 104.45 0.015076 20309100.0 93392.0 84246.0 93794.0 89980.0 93326.0 72141.7 73742.0 82201.0 55188.4 94042.0 True False 88201.64651779748 90707.39730641468 87759.39615518592 77724.56877584224 81601.55353497421 82078.56433785036 77171.14911700084 82440.1913008919 66227.62209273495 91326.76310954001 0.9657809333722451 0.9932181347281251 0.9609384277632255 0.8510601507097881 0.8935119427927047 0.8987350645440363 0.8450003754588289 0.9026947686956855 0.7251721164506792 1.0 16.478750080365998 -5.68682580024071 5.265866644540739 0.8704097049030067 0.9783019168987735 0.33293403627364393 0.06463908271626831 0.21505233513337868 10.602708148287611 0.016744061795716497 0.029238824273790653 2.0567153991933257e-06 5.68682580024071 0.10789221199576682 SKEFVSSDES(ph)SSGENK ddPTM_A459_Selumetinib_30min_R2 1 SKEFVSSDESSSGENK 16 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 S(0.002)KEFVS(0.013)S(0.02)DES(0.586)S(0.285)S(0.094)GENK 62.468 0.035879 11741000.0 44902.0 37105.0 44044.0 44771.0 36249.0 33030.0 40780.0 43485.0 32877.0 43410.0 True False 42406.52659694775 39950.83418862039 41210.25699148136 38673.11256571717 31695.076549828365 37579.582683513116 42676.35080403703 43611.53415067071 39453.31866013238 42156.640507274766 1.0059275617474752 0.9476759463725832 0.9775507843033627 0.9173670411199759 0.7518406630233949 0.8914273583310841 1.0123280766804124 1.0345116125452378 0.935874353017388 1.0 15.363472281709376 -7.264305998788372 24.85177844750698 0.9985544815424862 0.9122637492090138 0.2514494892028363 0.067748515027417 362.5936620757651 3143428.9173898133 0.03038586266810648 0.02153644891699579 5.441191377978706e-08 7.264305998788372 -0.0862907323334724 SKEFVSSDESS(ph)SGENK ddPTM_A459_Selumetinib_30min_R1 1 SKEFVSSDESSSGENK 16 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 SKEFVS(0.032)S(0.075)DES(0.28)S(0.538)S(0.074)GENK 117.98 0.0085404 7204600.0 1058.9 1682.2 1962.9 1724.5 1773.4 1508.7 1544.2 1356.2 875.55 1677.7 True False 1083.5703097392732 1485.2472419664364 1696.3489614379066 1423.348447874204 1612.9962831191997 1493.5238477899982 1427.7197507574476 1320.2291704415488 1485.7444023581115 1893.0491371818773 0.5723941806140068 0.784579339645392 0.8960934653620285 0.7518814065191664 0.8520625542348133 0.7889514426515944 0.7541905398625041 0.6974088228934894 0.7848419637801333 1.0 10.886496143695558 -12.090476036161661 1.8125019241268494 3.460032621556417 0.7697757690305289 0.4206625816593015 0.08264422512228566 1990095.6266296185 103777.27541615891 20100617.375901233 0.020927542259615503 8.11940049558517e-13 12.090476036161661 -2.690256852525888 SKEPHELVGS(ph)SPHR ddPTM_A459_Selumetinib_30min_R2 1 SKEPHELVGSSPHR 14 1 Q3T8J9-3;Q3T8J9 Q3T8J9-3 GON4L GON-4-like protein 1 SKEPHELVGS(0.789)S(0.211)PHR 103.01 0.0030775 4368900.0 43836.0 41751.0 76048.0 72639.0 84666.0 60733.0 48695.0 55379.0 62625.0 72964.0 True False 41399.7706094116 44953.16744937583 71155.1544748019 62745.442890735765 74029.50015635646 69098.41947071756 50959.413987311964 55540.143721513 75151.74988869995 70857.33973676112 0.5842693327637476 0.6344179391489901 1.0042030188989197 0.885517902927749 1.0447682686279232 0.9751765974763089 0.719183279765074 0.7838304955823583 1.0606064264886714 1.0 16.112629681575996 -5.206921040533617 6.615603380768546 0.9223097715472638 0.604212646072857 0.5985335120094059 0.10609834289619273 0.17303802927730297 16.865813948638266 0.02851768032809512 0.07646356416409364 6.2098192524399915e-06 5.206921040533617 -0.3180971254744068 SKESVPEFPLS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 3 SKESVPEFPLSPPK 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 SKESVPEFPLS(1)PPK;SKESVPEFPLS(1)PPK;SKESVPEFPLS(1)PPK 157.91 0.0014705 4066810000.0 18257.4 46948.2 21027.6 32161.3 19795.9 23000.1 21343.1 21781.7 15169.6 23795.7 True False 18682.761897283795 41451.48291837393 18172.167416338954 26544.9326973712 18005.364340250017 22768.739876419917 19733.172783571605 21203.978559067018 25741.70325625219 26850.109884746256 0.6958169622947282 1.5438105503591557 0.6768004858953183 0.9886340432614606 0.6705881062512521 0.847994290308473 0.7349382504680982 0.7897166398977441 0.9587187302677014 1.0 14.712640372037757 -5.320570309883768 24.99996362362021 0.8226443914875143 1.119826542354552 0.20976191101574904 0.22155854904393474 296.83025776234894 125496.1545340154 0.052535468201338024 0.10936133576673317 4.780019739986857e-06 5.320570309883768 0.2971821508670376 SKESVPEFPLS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 3 SKESVPEFPLSPPK 14 1 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 SKESVPEFPLS(1)PPK;SKESVPEFPLS(1)PPK;SKESVPEFPLS(1)PPK 120.63 0.010427 1940900000.0 185980.0 345567.0 176184.0 200028.0 153257.0 130690.0 150009.0 138874.0 101399.0 192909.0 True False 175643.97613692796 372070.87772696395 164848.51325463483 172783.84133245322 134003.48552503655 148691.36121430012 156984.71573719435 139278.1003481716 121681.63332477908 187339.2159322246 0.9375718546856323 1.9860811089418215 0.8799466381575632 0.9223047105896013 0.7152986354630427 0.7937012038530873 0.8379703894671372 0.7434540582178988 0.649525689105056 1.0 17.51529340663339 -5.423020865990426 8.724026095778038 0.8029220436489781 1.460822058352427 0.5109935701925452 0.25278022413132084 0.2268222803382053 18.12978426631983 0.06043123931208994 0.12606517510363804 3.775540506340003e-06 5.423020865990426 0.6579000147034488 SKESVPEFPLS(ph)PPKKK ddPTM_A459_Selumetinib_30min_R2 1 SKESVPEFPLSPPKKK 16 3 A2A2D0;P16949;P16949-2 A2A2D0 STMN1 Stathmin 1 SKESVPEFPLS(1)PPKKK 70.26 0.030327 4700800.0 42028.0 94458.0 62688.0 74610.0 58466.0 35410.0 14025.0 18551.0 7441.0 65821.0 True False 39692.25201141419 101702.62486965903 58654.722329533746 64447.98929057113 51120.97838732836 40287.4060800242 14677.190290010269 18604.980338716625 8929.407918911244 63920.57670650391 0.6209620447209686 1.5910780238519155 0.9176187911891233 1.0082510611017932 0.7997577778757244 0.6302728816888938 0.22961604926378687 0.29106402503442325 0.13969535913155612 1.0 15.963992804208642 -6.685299275053969 1.524691457119602 0.35828551168662004 1.079119398852464 0.4280556977195602 0.31588876580090636 0.31692103723913584 1.529909620562089 0.12951452799965965 0.1251046731442885 2.0639573796570516e-07 6.685299275053969 0.7208338871658441 SKETSSPGTDDVFTPAPSDS(ph)PSSQR ddPTM_A459_Selumetinib_30min_R2 2 SKETSSPGTDDVFTPAPSDSPSSQR 25 1 P19634 P19634 SLC9A1 Sodium/hydrogen exchanger 1 1 SKETSSPGTDDVFTPAPS(0.087)DS(0.83)PS(0.063)S(0.021)QR;SKETSSPGTDDVFTPAPS(0.046)DS(0.693)PS(0.215)S(0.046)QR 157.01 4.111e-13 21462000.0 196107.0 76746.0 144580.0 156820.0 94709.0 75786.0 210840.0 137622.0 102712.0 102236.0 True False 185208.15801852112 82632.17142271563 135277.88020680196 135460.8454704107 82810.80871079743 86224.83358318881 220644.47777153424 138022.45723545153 123257.27001306423 99284.18103897147 1.865434715584977 0.832279327461849 1.362532064938946 1.3643749090022612 0.8340785797315704 0.8684649727769166 2.2223528004418536 1.390175713704828 1.2414593012020994 1.0 16.599276250831373 SKGDCQTLSEGS(ph)PGSSQSGSR ddPTM_A459_Selumetinib_30min_R2 1 SKGDCQTLSEGSPGSSQSGSR 21 1 O94972-2;O94972-3;O94972 O94972-2 TRIM37 E3 ubiquitin-protein ligase TRIM37 1 S(0.043)KGDCQTLS(0.001)EGS(0.796)PGS(0.145)S(0.011)QS(0.004)GSR 129.98 2.9878e-05 3731800.0 11601.0 12144.0 11823.0 12412.0 13220.0 8343.0 9497.2 10879.0 9906.1 11539.0 True False 10956.262862482536 13075.405750885491 11062.321051909088 10721.464188105729 11559.185411700486 9492.172519786554 9938.83861834479 10910.6560888846 11887.596799560091 11205.839088077482 0.9777280198623872 1.1668386140576608 0.9871925667466445 0.9567747764210618 1.031532339599535 0.8470737840494075 0.8869339047460778 0.9736581083421996 1.0608395057366091 1.0 13.451963060783697 -5.497394982100725 19.51732038765901 0.9597538252982143 1.073467008562681 0.24908487240959765 0.07285339494410309 59.27969746607415 45397.86012558031 0.019335709527949285 0.03974266092026544 3.181302874602837e-06 5.497394982100725 0.11371318326446667 SKGDCQTLSEGSPGS(ph)SQSGSR ddPTM_A459_Selumetinib_30min_R2 1 SKGDCQTLSEGSPGSSQSGSR 21 1 O94972-2;O94972-3;O94972 O94972-2 TRIM37 E3 ubiquitin-protein ligase TRIM37 1 SKGDCQTLS(0.002)EGS(0.347)PGS(0.535)S(0.051)QS(0.051)GS(0.013)R 94.49 0.00024425 2894900.0 20114.0 18062.0 20860.0 23832.0 25549.0 19458.0 18839.0 22779.0 19295.0 22502.0 True False 18996.14440272162 19447.297321516275 19517.890310650728 20586.0404875069 22339.306209042028 22138.162877862487 19715.05082877031 22845.28311873355 23154.539147344767 21852.308792782704 0.8692969050938725 0.8899424544073463 0.8931729134770886 0.9420533401169023 1.022285856422648 1.0130811845920005 0.9021953247924869 1.0454402477727571 1.059592346369925 1.0 14.415498094420887 -5.964931061544555 2.484500511283964 1.0044361587916035 0.8826439616213073 0.6554222952569235 0.04009002640141046 0.1927982692988039 2.405997348542546 0.013099619785561102 0.020461130415043056 1.0840989866158004e-06 5.964931061544555 -0.12179219717029621 SKGHYEVTGS(ph)DDETGK ddPTM_A459_Selumetinib_30min_R1 3 SKGHYEVTGSDDETGK 16 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 SKGHYEVT(0.009)GS(0.895)DDET(0.096)GK;SKGHYEVT(0.002)GS(0.978)DDET(0.02)GK;SKGHYEVT(0.001)GS(0.996)DDET(0.004)GK 196.76 6.277499999999999e-07 96935100.0 12166.1 12277.699999999999 9745.6 10070.1 12625.600000000002 9963.2 12256.199999999999 9727.199999999999 3225.1499999999996 6854.4 True False 12449.546458890332 10840.221176252122 8422.201048748919 8311.54607418847 11483.61670923073 9862.979253861811 11331.704966476775 9469.203057601413 5472.8439943638405 7734.229007509959 1.6096687138177297 1.4015904061964335 1.088951599515729 1.0746444236546313 1.4847784695901949 1.2752375504119196 1.4651369846268654 1.224324111479863 0.7076133883609721 1.0 12.917041767353762 -8.125085482288032 5.055880261592948 0.861461057887977 1.3288332462661137 0.5541777082208146 0.17225960674693888 0.17515389087964228 6.30415716333885 0.12734418490342295 0.04593413081957572 7.497466219989571e-09 8.125085482288032 0.46737218837813665 SKGHYEVTGS(ph)DDETGKLQGSGVSLASK ddPTM_A459_Selumetinib_30min_R2 2 SKGHYEVTGSDDETGKLQGSGVSLASK 27 2 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.001)KGHY(0.001)EVT(0.03)GS(0.931)DDET(0.024)GKLQGS(0.01)GVS(0.003)LASK;S(0.006)KGHY(0.005)EVT(0.151)GS(0.577)DDET(0.094)GKLQGS(0.127)GVS(0.03)LAS(0.009)K 54.537 0.0040354 23004000.0 86932.0 90249.0 110242.0 148412.0 123402.0 85748.0 66644.0 68153.0 62829.0 142935.0 True False 82100.66745636848 97170.80810372723 103149.14974241387 128198.0295750201 107899.13753212271 97559.00865715671 69743.07805258068 68351.31394666347 75396.55558893623 138808.09516027005 0.5914688719096226 0.7000370402859593 0.7431061540273729 0.9235630632853264 0.777325972289589 0.7028337111356042 0.5024424402053367 0.49241590605896546 0.5431711709744461 1.0 17.082732181452556 -7.053489467635361 6.243194185708353 0.5925819489580051 0.7529734041352965 0.07871793699448615 0.15662206042858864 0.384999131872581 34.04914690747146 0.058814400988473244 0.046034106331023665 8.841186102895772e-08 7.053489467635361 0.16039145517729136 SKGHYEVTGSDDET(ph)GKLQGSGVSLASK ddPTM_A459_Selumetinib_30min_R1 1 SKGHYEVTGSDDETGKLQGSGVSLASK 27 2 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.001)KGHY(0.008)EVT(0.292)GS(0.227)DDET(0.468)GKLQGS(0.003)GVSLASK 79.021 0.00036889 29775000.0 1271.5 1258.6 1871.5 1782.7 1941.3 1361.6 1546.9 1341.6 427.68 573.6 True False 1301.1234760916861 1111.2425268927345 1617.360579413645 1471.3849104235098 1765.709757764352 1347.9035402338836 1430.216087583665 1306.0164098690327 725.7417234886836 647.2271473371429 2.0103042362250085 1.7169281780973942 2.4989072013865266 2.273367111495804 2.7281144881343913 2.082581896911311 2.209759113887509 2.017864076379238 1.1213091516240776 1.0 9.338128311305411 -8.236690881746384 2.8350238203216773 0.9837488520265932 2.223402265199449 0.7610688943007816 0.2561286881905599 0.13348840734551637 1.9832973787814174 0.24570362708052465 0.07193527290214188 5.798412638268674e-09 8.236690881746384 1.239653413172856 up SKHDSSAPDPAPDS(ph)ADEVMPEAVPEVASEPGLESASHPNVDR ddPTM_A459_Selumetinib_30min_R2 1 SKHDSSAPDPAPDSADEVMPEAVPEVASEPGLESASHPNVDR 42 1 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 SKHDS(0.002)S(0.002)APDPAPDS(0.995)ADEVMPEAVPEVAS(0.001)EPGLESASHPNVDR 66.479 5.6787e-08 2898400.0 579.73 1134.4 3040.9 5826.6 8501.6 4586.2 1753.8 3403.9 5460.0 5466.8 True False 547.5109274430655 1221.404832329093 2845.2518046815817 5033.007028554368 7433.553002731682 5217.907420621492 1835.3551750887705 3413.804785454019 6552.152565146534 5308.959279547797 0.10312961516813536 0.23006483342873352 0.5359340041734003 0.9480214037322708 1.4001902465834795 0.9828493958736747 0.34570903230681793 0.6430271180653693 1.234168924668156 1.0 12.374213360495599 -5.476609816631412 2.490971330570408 0.9167823412151729 0.15287884118431425 0.5590467314916352 0.2755578365220497 0.24676074388653083 2.9917672695164534 0.08669964229242241 0.21149610089615117 3.3372610779871427e-06 5.476609816631412 -0.7639035000308586 SKLESVISDEGDLQFPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SKLESVISDEGDLQFPSPK 19 1 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 SKLESVISDEGDLQFPS(1)PK 112.45 0.00031443 8463600.0 1736.4 2274.6 2507.3 3020.2 2010.9 2292.3 1917.2 1710.5 1130.5 1573.2 True False 1776.8547415537585 2008.2887745671487 2166.822431613054 2492.778766175511 1829.0144500532297 2269.2415432418725 1772.5840604534244 1665.1319835129557 1918.3759315468512 1775.1355442656782 1.0009684878958307 1.1313439027541523 1.2206518193005962 1.4042751688613733 1.0303519953513407 1.2783483213844336 0.9985626540911222 0.9380308951008991 1.0806926478059045 1.0 10.793713473546417 -7.283520407607276 23.275900530563945 0.9991573752836557 1.181110990654628 0.3582295961049393 0.11351771029042253 379.3670937579685 399892.64674779726 0.04813532841283278 0.03249275525434239 5.205705464854896e-08 7.283520407607276 0.18195361537097232 SKLPDGPTGS(ph)SEEEEEFLEIPPFNK ddPTM_A459_Selumetinib_30min_R1 1 SKLPDGPTGSSEEEEEFLEIPPFNK 25 1 A6NNK5;Q12888;Q12888-3;Q12888-2 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SKLPDGPT(0.076)GS(0.462)S(0.462)EEEEEFLEIPPFNK 69.35600000000001 0.00075377 7904500.0 1734.1 2179.3 1923.9 2113.1 1936.3 1807.2 1951.6 1767.3 1189.1 1444.5 True False 1774.501156028778 1924.1465428709157 1662.6449472262411 1744.0867527996402 1761.1620068815303 1789.0212088063133 1804.3892407578257 1720.4254630005526 2017.815851572188 1629.9156456215178 1.0887073578290163 1.1805190949849445 1.0200803653199138 1.0700472490615223 1.0805234072159395 1.0976158266915252 1.107044555100137 1.055530369085157 1.2379879026210319 1.0 10.670581586055484 SKPDPEVGPLLGVQPLPGS(ph)PTADR ddPTM_A459_Selumetinib_30min_R2 2 SKPDPEVGPLLGVQPLPGSPTADR 24 1 A0A6E1W9L1;Q9H5J0 A0A6E1W9L1 ZBTB3 Zinc finger and BTB domain-containing protein 3 1 SKPDPEVGPLLGVQPLPGS(0.699)PT(0.301)ADR;SKPDPEVGPLLGVQPLPGS(0.5)PT(0.5)ADR 134.98 2.7185e-07 1603100.0 46797.0 46346.0 47277.0 57643.0 55727.0 42586.0 39017.0 38624.0 37263.0 52033.0 True False 44196.210083233775 49900.58917412213 44235.24929130559 49791.923960278655 48726.076054298996 48451.83494278202 40831.367810718795 38736.38944545261 44716.64121521161 50530.672092030116 0.8746412476513362 0.9875306840019773 0.8754138320333669 0.9853802037224837 0.964287115864114 0.9588598951254406 0.8080511523051535 0.7665916134046881 0.8849405591473319 1.0 15.624871748450309 -7.253544688503848 24.89891994552505 0.8454451317721606 0.9432250378000132 0.2090118620865744 0.06840576741449127 660.7419861955741 2083906.5034416968 0.02528716831398836 0.019221098362850422 5.5777020514568555e-08 7.253544688503848 0.09777990602785258 SKPGAAMVEMADGYAVDR ddPTM_A459_Selumetinib_30min_R1 1 SKPGAAMVEMADGYAVDR 18 1 M0QYT0;P14866;M0QXS5;A0A3B3ITJ4;P14866-2 M0QYT0;P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 114.9 0.0023834 0.0 1760.3 1770.8 1941.5 2107.6 1818.3 1414.9 1772.5 1502.3 996.65 1406.5 False True 1801.3115650524537 1563.4739127774142 1677.8549638961201 1739.5472245518533 1653.8350860469386 1400.6673906264118 1638.7988979520626 1462.454123841867 1691.242257564059 1587.0379754701737 1.1350147840783706 0.9851521746442278 1.057224206244366 1.0960967862388407 1.0420891696413097 0.8825670288144504 1.0326147976809152 0.9214991364076227 1.0656596021673734 1.0 10.632120934805569 -6.542978955549909 24.99250688960637 0.9769884149884467 1.0625641577440823 0.3270285519738284 0.05989618166123782 274.8759700679022 341777.1371095274 0.018587982499652937 0.018590167598128284 2.8643167617016357e-07 6.542978955549909 0.08557574275563562 SKPIPIMPAS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 2 SKPIPIMPASPQK 13 1 O00429-4;O00429-5;O00429-3;O00429-9;O00429-2;O00429;O00429-8;O00429-6;O00429-7 O00429-4 DNM1L Dynamin-1-like protein 1 SKPIPIMPAS(1)PQK;SKPIPIMPAS(1)PQK 172.91 0.00077505 70893000.0 7975.4 11344.099999999999 7748.6 7788.0 7200.099999999999 7433.900000000001 8404.7 8291.7 4060.8 8535.7 True False 8161.211302573045 10015.927498270989 6696.382680013124 6427.9719988659335 6548.852226280898 7359.121715441149 7770.72671233721 8071.777180762572 6890.881010902655 9631.34023975881 0.8473598792495175 1.0399308142935888 0.6952700780281869 0.6674016117020598 0.679952328882205 0.7640807543131128 0.8068167585087624 0.8380741391983788 0.7154643942965115 1.0 13.23352085352171 -5.267599009049688 24.997263009296173 0.7591966339747989 0.9436453494692301 0.30616752507665745 0.10283304514394886 484.706989557979 1967063.8672318484 0.02612020677360712 0.056656506281193196 5.400089912293077e-06 5.267599009049688 0.1844487154944312 SKPIPIMPAS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 3 SKPIPIMPASPQK 13 1 O00429-4;O00429-5;O00429-3;O00429-9;O00429-2;O00429;O00429-8;O00429-6;O00429-7 O00429-4 DNM1L Dynamin-1-like protein 1 SKPIPIMPAS(1)PQK;SKPIPIMPAS(1)PQK;SKPIPIMPAS(1)PQK 95.365 0.00828 566815000.0 1631050.0 1422460.0 1649460.0 1620910.0 1689140.0 1361780.0 1804770.0 1735980.0 1454030.0 1424760.0 True False 1540402.7706104768 1531558.1080702033 1543335.5393962567 1400139.2617742887 1476935.1320968051 1549352.8339919606 1888695.3810839127 1741031.4143930415 1744876.6289926758 1383623.476828953 1.1133106632021288 1.106918272000048 1.115430292447291 1.0119366180336773 1.0674400635942574 1.119779231805775 1.3650356565302757 1.2583130046211786 1.2610920949329785 1.0 20.400019967489484 -7.0520957749358555 10.099903945971864 1.242774453520083 1.0833032620951382 0.3327908006804612 0.09071936862442184 0.6234310968680203 118.72660411832642 0.032933361965790824 0.02557922024400287 8.869603891473701e-08 7.0520957749358555 -0.15947119142494492 SKPIPIMPAS(ph)PQKGHAVNLLDVPVPVAR ddPTM_A459_Selumetinib_30min_R1 2 SKPIPIMPASPQKGHAVNLLDVPVPVAR 28 2 O00429-4;O00429-5;O00429-3;O00429-9;O00429-2;O00429;O00429-8;O00429-6;O00429-7 O00429-4 DNM1L Dynamin-1-like protein 1 S(0.009)KPIPIMPAS(0.991)PQKGHAVNLLDVPVPVAR;S(0.005)KPIPIMPAS(0.995)PQKGHAVNLLDVPVPVAR 69.435 0.00020955 21522600.0 3534.16 3685.84 6779.5 6956.77 5375.3 4237.91 4080.99 4140.53 2290.0299999999997 3223.9300000000003 True False 3616.499051721737 3254.300139299471 5858.881137127867 5741.900714246345 4889.105064086295 4195.28047311441 3773.1576386761003 4030.709694063081 3886.0136528263874 3637.7528192375116 0.9941574459365743 0.8945907820041457 1.6105770315521089 1.578419700173546 1.3439904542802532 1.1532615550260938 1.037222105559929 1.1080218734894514 1.0682456576697568 1.0 11.828831801654935 -6.950052634009465 4.158392528623992 1.0650478747745862 1.296149887809708 0.21067224335122303 0.2099017641952635 0.39997430225193803 14.638127191119848 0.08808234619041616 0.07543948283281184 1.1218824803167902e-07 6.950052634009465 0.2311020130351218 SKPIPIMPAS(ph)PQKGHAVNLLDVPVPVAR ddPTM_A459_Selumetinib_30min_R2 1 SKPIPIMPASPQKGHAVNLLDVPVPVAR 28 2 O00429-4;O00429-5;O00429-3;O00429-9;O00429-2;O00429;O00429-8;O00429-6;O00429-7 O00429-4 DNM1L Dynamin-1-like protein 1 S(0.065)KPIPIMPAS(0.935)PQKGHAVNLLDVPVPVAR 41.188 0.034098 28771000.0 21601.0 25349.0 25038.0 31574.0 27476.0 14466.0 14164.0 14671.0 12033.0 26541.0 True False 20400.50289565427 27293.18679011828 23427.082339313187 27273.56673181198 24024.21924144347 16458.560190726643 14822.654065433551 14713.690181085205 14439.936230111409 25774.69236820041 0.79149355515969 1.0589141627851713 0.9089180194529269 1.0581529487219337 0.9320855860566316 0.6385550584119651 0.5750855860348129 0.5708580327902675 0.5602369961911443 1.0 14.653667588073182 -6.745145212792413 5.486447481507986 0.6348539730146308 0.962057883677815 0.49252701105157837 0.1404683005193764 0.1241439559087139 11.130786755569144 0.04516101876943692 0.04317087176324061 1.7982695365405396e-07 6.745145212792413 0.3272039106631842 SKPPPTYES(ph)EEEDK ddPTM_A459_Selumetinib_30min_R1 2 SKPPPTYESEEEDK 14 1 O60885;O60885-2;O60885-3 O60885 BRD4 Bromodomain-containing protein 4 1 SKPPPT(0.006)YES(0.994)EEEDK;SKPPPT(0.008)YES(0.992)EEEDK 216.29 6.3747e-08 17868800.0 4388.4 6631.4 3468.2999999999997 3531.6 2801.8999999999996 3633.6000000000004 4721.3 4595.5 3127.5 6156.2 True False 4490.641181660047 5854.992605145776 2997.3239100081987 2914.872356342442 2548.468639715624 3597.0492830448297 4365.168539859564 4473.6124117122445 5307.13907643766 6946.408236466043 0.6464695175970024 0.8428805802701398 0.4314926229462545 0.4196229557946873 0.3668757367781982 0.5178286620359667 0.6284065651287327 0.6440180679602812 0.76401197507759 1.0 12.76205148424162 -8.479074878895664 1.1048024861965886 0.996324595999819 0.5392191300340632 0.5501083388834309 0.12831666545373296 0.4391063929909921 1.175799274185346 0.13729293810079204 0.04432185537924501 3.3183723889292764e-09 8.479074878895664 -0.45710546596575585 SKPPPTYES(ph)EEEDK ddPTM_A459_Selumetinib_30min_R2 4 SKPPPTYESEEEDK 14 1 O60885;O60885-2;O60885-3 O60885 BRD4 Bromodomain-containing protein 4 1 SKPPPT(0.001)Y(0.004)ES(0.995)EEEDK;SKPPPTYES(1)EEEDK;SKPPPTYES(1)EEEDK;S(0.001)KPPPT(0.002)YES(0.997)EEEDK 139.9 0.00031172 82311000.0 246411.0 168408.0 202226.0 197483.0 176803.0 159396.0 273730.0 248728.0 191157.0 154479.0 True False 232716.46308138786 181324.3520829316 189214.9993270207 170585.47472282342 154591.42650112553 181351.35214717718 286458.98738570506 249451.75730086322 229393.74137284167 150018.78988535606 1.5512487686324434 1.2086776077949914 1.2612753340539427 1.1370940590387668 1.0304804259470688 1.2088575856782031 1.909487388910524 1.662803422767865 1.5291000650528093 1.0 17.194783684336002 -7.212934665333189 24.746999146944773 1.580581477493833 1.2195647793019375 0.2395727670739869 0.24682105002795504 395.3129972993223 201687.8735263435 0.09170971558346828 0.07103788798331545 6.124425198083329e-08 7.212934665333189 -0.3610166981918954 SKPPPTYES(ph)EEEDKCKPMSYEEK ddPTM_A459_Selumetinib_30min_R1 1 SKPPPTYESEEEDKCKPMSYEEK 23 3 O60885;O60885-2;O60885-3 O60885 BRD4 Bromodomain-containing protein 4 1 SKPPPT(0.009)Y(0.027)ES(0.942)EEEDKCKPMS(0.011)Y(0.012)EEK 58.107 0.010432 58127000.0 2744.6 4469.1 3130.4 3455.3 2417.8 3396.0 2714.1 2773.5 1647.3 3306.7 True False 2808.543839938057 3945.855694371778 2705.3088740563576 2851.896719014054 2199.1104168972606 3361.839323321292 2509.373251865554 2699.937770402328 2795.3477859682666 3731.1471549855814 0.7527293144107875 1.0575449132579244 0.7250608892338936 0.7643484967360058 0.5893925716542152 0.9010202984969868 0.6725473822474447 0.723621357789294 0.7491925860477269 1.0 11.86540354526743 -5.30176486976117 24.95286587409563 0.750945723416956 0.9051373699675018 0.15135998693449604 0.12839462030053797 664.1655797008644 410975.46480147616 0.03098210556331712 0.06449550210330239 4.9915466033490345e-06 5.30176486976117 0.15419164655054585 SKPS(ph)PQKDQALGDGIAPPQK ddPTM_A459_Selumetinib_30min_R1 1 SKPSPQKDQALGDGIAPPQK 20 2 Q9H9J4-2;Q9H9J4;B4DP25;E5RJP3 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 S(0.482)KPS(0.518)PQKDQALGDGIAPPQK 66.264 0.017953999999999998 11955000.0 1980.1 2154.1 2877.1 2919.4 2288.0 2302.7 2461.6 2077.7 1538.0 2052.1 True False 2026.2324773961038 1901.896970586078 2486.405622779051 2409.581593925166 2081.0508039792085 2279.536928684317 2275.919530154471 2022.5926466792562 2609.8736689244192 2315.5070241467056 0.8750707539497949 0.8213738722243573 1.0738061240368397 1.0406280649539934 0.8987451915617067 0.9844655640914568 0.9829033150928043 0.8734988171433459 1.1271283747827072 1.0 11.177112418160721 -5.246694256064046 24.984594855858134 0.9901345478007888 0.8482222941369572 0.40464421399715333 0.07203970134226613 807.4736066209414 1368203.293421303 0.01798054436501275 0.04713892282206188 5.666380626591354e-06 5.246694256064046 -0.14191225366383164 SKPS(ph)PQKDQALGDGIAPPQK ddPTM_A459_Selumetinib_30min_R2 1 SKPSPQKDQALGDGIAPPQK 20 2 Q9H9J4-2;Q9H9J4;B4DP25;E5RJP3 Q9H9J4-2 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 S(0.016)KPS(0.984)PQKDQALGDGIAPPQK 86.22200000000002 0.0026024 9310200.0 101860.0 100980.0 91863.0 99368.0 99747.0 78826.0 84784.0 98057.0 72422.0 101150.0 True False 96199.02897788741 108724.84129812375 85952.63459287194 85833.90698063889 87215.89011050593 89683.56598881642 88726.62399630884 98342.3296357898 86908.42363975132 98229.53668073802 0.9793289496065721 1.106844692258879 0.8750182225966512 0.8738095473219328 0.8878784636231337 0.9129999898126631 0.9032580931811255 1.0011482590559129 0.8847483819680209 1.0 16.58386927390214 -5.268163003545119 24.995774661597817 0.9141313281729027 1.0430868230236394 0.47463854674949024 0.05282354929068424 377.9988163252436 1405255.0627826771 0.013417977305302404 0.029017160776701367 5.393081662413643e-06 5.268163003545119 0.12895549485073676 SKPVLEPLT(ph)PPLGSPRPR ddPTM_A459_Selumetinib_30min_R1 2 SKPVLEPLTPPLGSPRPR 18 2 Q9H7P9;Q9H7P9-3;H7BXC7;E7ESZ3;Q9H7P9-2 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 SKPVLEPLT(0.995)PPLGS(0.005)PRPR;SKPVLEPLT(1)PPLGSPRPR 115.31 0.0034624 57587000.0 6562.5 8332.1 9869.7 10691.0 8629.5 7660.3 8859.7 7429.3 4300.6 6495.0 True False 6715.393481597868 7356.573858511795 8529.448950381424 8824.017544924975 7848.963248661967 7583.244336995907 8191.405696014606 7232.250830232566 7297.804096603612 7328.696516657506 0.9163148543993257 1.0038038608626958 1.163842564771881 1.2040364237854209 1.0709903501696294 1.0347330278665292 1.1177165922202175 0.986839994505745 0.9957847319801443 1.0 12.839340907826113 -7.776263779836535 24.940551007820503 0.9934842264710523 1.0773738168464502 0.18109542799134637 0.07645339289526284 439.26721691724197 739011.8046399083 0.04550950606803985 0.022003780495381937 1.6739258656119614e-08 7.776263779836535 0.0838895903753979 SKPVLEPLT(ph)PPLGSPRPR ddPTM_A459_Selumetinib_30min_R2 2 SKPVLEPLTPPLGSPRPR 18 2 Q9H7P9;Q9H7P9-3;H7BXC7;E7ESZ3;Q9H7P9-2 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 SKPVLEPLT(1)PPLGSPRPR;SKPVLEPLT(1)PPLGSPRPR 106.38 0.0021533 51248000.0 175546.0 167363.0 185974.0 175885.0 166550.0 106402.0 128279.0 127938.0 103625.0 131048.0 True False 165789.8560863167 180199.20394313664 174008.63531318097 151929.15958145162 145626.5000241088 121057.90967881205 134244.2276800162 128310.27839872394 124352.89552441587 127264.30373640526 1.3027208040182818 1.4159446023165474 1.3673012007639973 1.193808123102085 1.144283948826185 0.9512322475715725 1.054845889528206 1.0082189163151762 0.9771231356593157 1.0 16.957468290029396 -6.171689896474012 1.4417012463303172 1.0018403329283434 1.3738606478948576 0.917672925373652 0.046581124654900115 0.10119613427841262 0.4222260897663434 0.016675673012668205 0.02505436051957321 6.734573599722639e-07 6.171689896474012 0.3720203149665142 SKPVLEPLTPPLGS(ph)PRPR ddPTM_A459_Selumetinib_30min_R2 1 SKPVLEPLTPPLGSPRPR 18 2 Q9H7P9;Q9H7P9-3;H7BXC7;E7ESZ3;Q9H7P9-2 Q9H7P9 PLEKHG2 Pleckstrin homology domain-containing family G member 2 1 SKPVLEPLT(0.027)PPLGS(0.973)PRPR 76.158 0.005806100000000001 2959400.0 34119.0 37460.0 38687.0 34114.0 34137.0 29814.0 30601.0 31684.0 20288.0 31738.0 True False 32222.80256917864 40333.061547115496 36197.920539220766 29467.614350067583 29848.404871347928 33920.60787545444 32024.007134731157 31776.19519443143 24346.166894082962 30821.641474772794 1.0454603008588197 1.3085955068333301 1.1744319512913808 0.9560689483130395 0.968423595991101 1.100545144658117 1.039010435603908 1.0309702427899543 0.7899049411112662 1.0 14.911656077367523 -5.73366916381054 8.721646631481061 0.9914055481388637 1.1900882986137755 0.45159039750073027 0.09663801184126511 0.2211094770670346 61.484030244348524 0.02618000643693255 0.04466358814728903 1.8464214476906535e-06 5.73366916381054 0.1986827504749118 SKPYEGSQRNS(ph)TELAPPLPVR ddPTM_A459_Selumetinib_30min_R1 1 SKPYEGSQRNSTELAPPLPVR 21 2 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 SKPYEGSQRNS(0.754)T(0.246)ELAPPLPVR 77.795 0.0028636 40923000.0 761.17 1136.9 1036.0 1342.7 1258.5 922.78 879.42 937.34 631.19 607.07 True False 778.903780021005 1003.7912194695292 895.3168903406552 1108.2226506005766 1144.6688972062218 913.4976710172027 813.0846413748958 912.4786982905782 1071.0833297063743 684.9933478625512 1.137096852767244 1.4654028723078156 1.3070446496077606 1.6178589968189725 1.67106571294165 1.3335861930158517 1.1869964050191726 1.332098627144148 1.563640483588017 1.0 9.419946167552549 -6.981750485576541 24.929949931842664 1.292920483428644 1.4495182929274149 0.14414008607444417 0.1916837584429118 504.9304017610915 689763.2377277236 0.06856097768406703 0.060454980675634325 1.042916442199841e-07 6.981750485576541 0.15659780949877078 SKS(ph)DATASISLSSNLK ddPTM_A459_Selumetinib_30min_R2 2 SKSDATASISLSSNLK 16 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 S(0.263)KS(0.736)DAT(0.001)ASISLSSNLK;S(0.021)KS(0.978)DAT(0.001)ASISLSSNLK 159.88 0.00027659 20480600.0 195622.0 166912.0 183005.0 204608.0 202503.0 152305.0 164406.0 201541.0 156234.0 188060.0 True False 184750.11237691232 179713.61369332988 171230.65754077848 176740.03743151305 177062.76274021066 173283.6312628659 172051.20476430876 202127.45094309116 187485.16554269282 182630.21916143972 1.0116075708894523 0.9840299952466703 0.9375811863282912 0.9677480443435271 0.969515141323312 0.9488223365142452 0.9420741296500366 1.1067579717703588 1.0265834778250005 1.0 17.4785659770384 -7.7468247540324775 24.99999512507595 1.0500030584167068 0.9650704518616184 0.5534866911056069 0.03220326297161175 151.18688985631576 258623.63629255095 0.014903126647396401 0.008556352024590486 1.7913285428750424e-08 7.7468247540324775 -0.08493260655508839 SKS(ph)DSYTLDPDTLR ddPTM_A459_Selumetinib_30min_R2 1 SKSDSYTLDPDTLR 14 1 A0A499FJI4;O75592-2;O75592 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 S(0.052)KS(0.818)DS(0.041)YT(0.089)LDPDTLR 133.28 0.00351 23666000.0 35002.0 30077.0 30975.0 35389.0 38895.0 25075.0 25888.0 26773.0 25643.0 28171.0 True False 33056.72896410772 32383.809187202165 28982.102223030026 30568.957150569906 34008.66237428823 28528.85364181324 27091.84329609882 26850.904997491267 30772.316525284376 27357.630032951816 1.208318444408066 1.1837212926776333 1.0593791270706403 1.1173832350883501 1.2431143462838468 1.042811588849279 0.9902847309312663 0.981477743691606 1.124816604662744 1.0 14.7396556358039 -6.904874365835048 7.867105193280643 1.0217927282780037 1.1550670310841067 0.5585701123621031 0.059763064644428016 0.19520387999624447 14.151182928669508 0.021712414038115562 0.019148919818763887 1.2448746812126462e-07 6.904874365835048 0.13327430280610297 SKS(ph)EDMDNVQSK ddPTM_A459_Selumetinib_30min_R1 3 SKSEDMDNVQSK 12 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 S(0.001)KS(0.999)EDMDNVQSK;S(0.006)KS(0.993)EDMDNVQSK;S(0.021)KS(0.979)EDMDNVQSK 122.34 0.012505 66439400.0 14075.01 15616.25 16950.21 17975.24 15320.98 14574.09 16508.75 16842.35 9375.21 13568.25 True False 14402.930347798061 13787.892190202328 14648.46458283887 14836.20177104454 13935.200064138708 14427.487886814957 15263.481696229124 16395.63616633699 15909.046631753516 15309.867053446993 0.9407612944983258 0.9005886296770949 0.9567989409510117 0.96906143725815 0.9102103901680334 0.9423653279580002 0.9969702312204322 1.070919565081758 1.0391368243900994 1.0 13.902174134486073 -7.4213841761664145 3.0667886499360972 1.0409209344401513 0.9359526477537443 0.7658599910353159 0.025006176669470588 0.1190404379026712 2.1420371490614443 0.012049873247058617 0.007383936480772612 3.78979591943474e-08 7.4213841761664145 -0.10496828668640701 SKS(ph)EDMDNVQSK ddPTM_A459_Selumetinib_30min_R2 3 SKSEDMDNVQSK 12 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 S(0.013)KS(0.987)EDMDNVQSK;S(0.002)KS(0.588)EDMDNVQS(0.41)K;S(0.008)KS(0.538)EDMDNVQS(0.453)K 122.12 0.0024502 66391000.0 206254.0 176170.0 193721.0 185948.0 179890.0 140120.0 174118.0 174184.0 152442.0 181066.0 True False 194791.22838018023 189681.6725241681 181257.20176747703 160621.56162180804 157290.6099629956 159420.25811728314 182214.83200827174 174690.84660228665 182934.65958536018 175838.1541140344 1.1077870406547512 1.0787287519019104 1.0308183834205191 0.9134625100627586 0.8945192285230066 0.9066306395248898 1.0362644724426642 0.9934752072578986 1.0403581663324533 1.0 17.423888621020247 -5.453095643794956 3.2114809889523075 0.966140017480927 1.0930567883615874 0.4983016462082309 0.04962437826293725 0.22400586604186878 4.463937505509084 0.015234495314953968 0.03453358756024388 3.522932776630087e-06 5.453095643794956 0.12691677088066033 SKS(ph)EEAHAEDSVMDHHFR ddPTM_A459_Selumetinib_30min_R2 1 SKSEEAHAEDSVMDHHFR 18 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 S(0.14)KS(0.86)EEAHAEDSVMDHHFR 110.6 0.00058513 16768000.0 59615.0 58174.0 61513.0 51904.0 48202.0 23904.0 40103.0 37378.0 31227.0 42116.0 True False 56301.83695775333 62635.75874110773 57555.32055029044 44834.585660605844 42146.43382865257 27196.559021092886 41967.868962586945 37486.763791739 37473.27255528038 40900.00164949053 1.376572975234945 1.5314365822742688 1.4072204945988647 1.0962000941915446 1.0304751131758834 0.6649525164855747 1.0261092242061003 0.9165467550098731 0.9162168959410585 1.0 15.319813280900135 -5.909912878614155 1.973727597143424 0.9107767044792267 1.4667965433807273 0.8321486792380386 0.10315106174923377 0.12049719830914499 0.9538863591614979 0.032308666992117846 0.05572614519080057 1.2305155929022846e-06 5.909912878614155 0.5560198389015006 SKS(ph)ISSSNPDLAVAPGSVDDEVSR ddPTM_A459_Selumetinib_30min_R1 1 SKSISSSNPDLAVAPGSVDDEVSR 24 1 K7ESB7;K7EKT0;K7EP20;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 S(0.139)KS(0.215)IS(0.215)S(0.215)S(0.215)NPDLAVAPGSVDDEVSR 132.16 5.8669e-08 11717000.0 1690.0 2354.0 2510.0 2388.8 1935.4 2024.5 2300.4 1846.5 923.95 1853.6 True False 1729.3737118324411 2078.3925856550904 2169.155786443091 1971.6409233296029 1760.3434117226218 2004.135368098926 2126.878975937334 1797.524821722697 1567.8756673619741 2091.5276155929714 0.8268471804720323 0.9937198869190369 1.0371155371181227 0.9426798425373029 0.8416543958581895 0.9582160680822429 1.0169021724029879 0.8594315505669662 0.7496318268393811 1.0 11.030341331468328 -7.877509917881443 9.168003632956863 0.8516911652217753 0.9470221285056496 0.131190560741004 0.08560928643210991 0.4512989508131219 34.065089738274004 0.0464961600159802 0.022293150239051797 1.3258368395892205e-08 7.877509917881443 0.09533096328387425 SKS(ph)LGDLTSEDIACNFESK ddPTM_A459_Selumetinib_30min_R1 1 SKSLGDLTSEDIACNFESK 19 1 Q4KWH8-2;A0A2U3TZV8;Q4KWH8 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 S(0.187)KS(0.802)LGDLT(0.01)S(0.001)EDIACNFESK 100.39 0.00070187 17961000.0 2697.8 3563.7 4127.2 4500.8 3744.4 3308.6 3850.8 3408.6 1739.1 2910.8 True False 2760.6534909950065 3146.460347280816 3566.748909086826 3714.8197704796867 3405.719681127514 3275.31848796844 3560.3310557031327 3318.1928553067883 2951.1256811615435 3284.42953359302 0.8405275445124177 0.9579929528397366 1.0859568983308225 1.13103957094669 1.0369288323265708 0.9972259884003013 1.0840028745595551 1.010279813090352 0.8985200172442558 1.0 11.68142709797205 -4.901220014723183 3.2139776261005273 1.0351351334391647 0.8348864531837561 0.48127221295360634 0.060433654700435 0.24516276905669285 4.396304932179571 0.016317732887244023 0.105740291917977 1.2553938167726116e-05 4.901220014723183 -0.20024868025540865 SKS(ph)LKEGLTVQER ddPTM_A459_Selumetinib_30min_R1 1 SKSLKEGLTVQER 13 2 A0A494BZV2;Q6WCQ1-2;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;J3QL44 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(0.012)KS(0.971)LKEGLT(0.018)VQER 178.67 0.0035065 28323000.0 2322.4 2506.3 5478.7 5993.9 3764.4 3246.7 2377.7 2443.2 2037.3 1658.6 True False 2376.5074013962485 2212.8612308527413 4734.722632344925 4947.1778844379205 3423.9106846587993 3214.041145767739 2198.348174702748 2378.3983993679367 3457.1493014952666 1871.4974661321232 1.2698427031845485 1.1824014036343444 2.5299113239679185 2.6434328520157675 1.8295032435897935 1.7173633434889384 1.1746466209468809 1.2708531229184297 1.8472636827236828 1.0 10.869977379599884 -7.030745239531273 3.3658620914988897 1.3479941816531031 1.924446970544444 0.2369602855742392 0.47781584659870313 0.4147991612475232 9.660207924956767 0.20955606365883725 0.16708500987441566 9.316542307100263e-08 7.030745239531273 0.5764527888913409 SKS(ph)MDLGIADETK ddPTM_A459_Selumetinib_30min_R1 2 SKSMDLGIADETK 13 1 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-4;Q8TEW0-8 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.035)KS(0.965)MDLGIADETK;S(0.007)KS(0.991)MDLGIADET(0.002)K 169.61 0.0011842 54202000.0 4130.7 4438.849999999999 5132.7 5532.099999999999 4529.6 4727.68 4638.14 4563.05 2344.27 3823.6400000000003 True False 4226.937273056961 3919.1473784346194 4435.707531902972 4566.022585378303 4119.898479765835 4680.123831589993 4288.281365612061 4442.023091124696 3978.0549712935294 4314.441439407593 0.9797183094081706 0.9083788558670876 1.0281070201550886 1.0583114058920347 0.9549088885840874 1.0847577600294445 0.99393662559501 1.0295708386610114 0.9220324408528182 1.0 12.074958080507288 -5.271770571080269 24.92071835389694 1.0120128747609487 0.9440485811269517 0.22951206929322765 0.04730300248374907 792.383051679974 1911375.831984871 0.011809321231349704 0.02502864068901493 5.348468334546001e-06 5.271770571080269 -0.06796429363399703 SKS(ph)NPDFLK ddPTM_A459_Selumetinib_30min_R1 1 SKSNPDFLK 9 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;J3QL44;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 SKS(1)NPDFLK 150.14 0.006414199999999999 79845000.0 2150.7 2720.7 2012.6 2333.9 2131.4 2188.6 2147.7 1862.0 997.31 1868.7 True False 2200.8071254662896 2402.159179180886 1739.2999744204637 1926.328177728967 1938.6152463292324 2166.5846710898068 1985.6972598768111 1812.6137113716022 1692.3622293595658 2108.565847679427 1.0437459792343589 1.1392383983761152 0.824873444827271 0.9135726920024713 0.9193999079814211 1.0275157749871706 0.9417288352944546 0.8596429242968467 0.8026129377093382 1.0 11.042046360411083 -5.2537262933668405 24.940443730853715 0.9117821309423635 1.0914922007138237 0.5155590056342039 0.06991684706635362 460.0190047779473 1487472.6787093938 0.0185467520988544 0.047158781778379455 5.575370163525477e-06 5.2537262933668405 0.1797100697714602 SKS(ph)NPDFLK ddPTM_A459_Selumetinib_30min_R2 2 SKSNPDFLK 9 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H7C3G6;H0Y7E2;J3QL44;K7EL39;J3QRL2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 SKS(1)NPDFLK;S(0.001)KS(0.999)NPDFLK 97.957 0.011069 235800000.0 1019220.0 785650.0 979580.0 919450.0 1042710.0 871130.0 1029270.0 961830.0 910440.0 884030.0 True False 962575.8326609295 845906.8287370877 916554.889286064 794219.3238602817 911715.4478543286 991120.2501692044 1077133.094459814 964628.7660604719 1092553.4398190496 858505.7569142153 1.121222338823656 0.9853245850995656 1.0676164742103753 0.9251182271799754 1.0619794223994123 1.1544712917612274 1.2546603045871534 1.123613625525007 1.272622147283074 1.0 19.71146828303084 -6.722122286477646 3.715430460759265 1.176462594787321 1.0222439361691649 0.3641381775455734 0.08506916445395828 0.2127665479394 6.132987557145462 0.028064077264423167 0.026877690417887273 1.8961719313851213e-07 6.722122286477646 -0.1542186586181562 SKS(ph)PIPGQGYLGTER ddPTM_A459_Selumetinib_30min_R2 1 SKSPIPGQGYLGTER 15 1 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KRE4 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 S(0.271)KS(0.729)PIPGQGYLGTER 66.26100000000001 0.035019 4981900.0 16389.0 8309.1 12425.0 14528.0 17508.0 13918.0 17766.0 19432.0 14477.0 12743.0 True False 15478.164990365169 8946.381252032497 11625.589027317128 12549.261337802121 15308.488516494108 15835.078164975352 18592.15420266114 19488.543902859215 17372.804521177008 12375.076479709798 1.250753077424871 0.7229354312840816 0.9394357316804036 1.0140754570994301 1.2370419319503956 1.2795943678359143 1.5023870141849123 1.574822097852298 1.4038543155399075 1.0 13.59514982082712 -6.455798080248449 1.6421055002659848 1.408230894467923 0.9459238855076474 0.4553961483089374 0.18861776339787392 0.2879593633230735 1.5630365059597084 0.07025971163885748 0.08116156018179949 3.501079074570481e-07 6.455798080248449 -0.46230700896027555 SKS(ph)PLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSK ddPTM_A459_Selumetinib_30min_R1 1 SKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSK 36 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 S(0.265)KS(0.734)PLPPEEEAKDEEEDQT(0.001)LVNLDTYTSDLHFQVSK 79.553 7.7016e-07 219780000.0 9154.9 11232.0 12930.0 12900.0 10690.0 9772.7 10243.0 10942.0 4556.9 8955.2 True False 9368.191357665564 9916.952218384866 11174.177019406048 10647.257162990569 9723.091387472792 9674.39551090165 9470.362263313387 10651.7826153749 7732.72647719225 10104.687151034843 0.9271134491982909 0.9814210049411821 1.1058409678979202 1.0536948847446663 0.9622357666439014 0.9574166291641076 0.9372246880838371 1.054142741498338 0.765261344721625 1.0 13.30273703499916 -6.415085908074648 5.288793169887393 0.9471935943450858 1.0205225056881961 0.15591822621229168 0.08135971811039236 0.44965614362582224 18.328069304778197 0.025387718187006417 0.02871593518440599 3.8451571321803355e-07 6.415085908074648 0.07332891134311037 SKS(ph)PPKVPIVIQDDSLPAGPPPQIR ddPTM_A459_Selumetinib_30min_R2 2 SKSPPKVPIVIQDDSLPAGPPPQIR 25 2 Q7Z422-4;Q7Z422-5;Q7Z422;Q7Z422-2;Q7Z422-3 Q7Z422-4 SZRD1 SUZ domain-containing protein 1 1 S(0.178)KS(0.822)PPKVPIVIQDDSLPAGPPPQIR;S(0.171)KS(0.829)PPKVPIVIQDDSLPAGPPPQIR 106.73 1.1372e-07 41330100.0 219635.0 200158.0 196121.0 188612.0 194597.0 165884.0 200060.0 173751.0 129439.0 183278.0 True False 207428.5659685672 215509.47499059114 183502.78838039987 162922.72022615187 170149.9851407472 188733.0152549771 209363.1864113692 174256.58664397366 155330.4168278392 177986.2879265678 1.1654187993074303 1.210820662092264 1.0309939631760174 0.9153666955140345 0.9559724354212407 1.0603795239150282 1.1762882908021917 0.9790450077585026 0.8727100196163662 1.0 17.441406574604116 -5.325872578855985 4.97913950526131 1.0005746800157855 1.1882839555126181 0.48286882504680817 0.07869898947888461 0.1836632746338424 9.086178598773333 0.02277128346434828 0.05026291705838625 4.722015639485424e-06 5.325872578855985 0.18770927549683258 SKS(ph)PTISDK ddPTM_A459_Selumetinib_30min_R1 2 SKSPTISDK 9 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 S(0.066)KS(0.467)PT(0.467)IS(0.001)DK;S(0.005)KS(0.976)PT(0.018)ISDK 147.26 0.0078703 45761300.0 4765.1 5611.3 5487.8 5145.7 4666.299999999999 5900.8 4457.7 5611.6 5398.0 4979.6 True False 4876.117558729443 4954.326387377399 4742.586902327647 4247.100091751983 4244.233988902178 5841.443309497724 4121.452100085142 5462.762138954284 9160.01174567881 5618.780165411504 0.8678249397878569 0.8817441226612855 0.8440598782494481 0.7558758247736033 0.7553657313431023 1.0396283779630509 0.7335136771244899 0.9722327583809655 1.6302491779384212 1.0 12.456041240672533 -8.051318527340523 8.23320715430235 1.3133968769510582 0.8433015642705767 0.568985832941046 0.1633125850894532 0.2246219748877732 33.154179598178 0.10027608209016164 0.03812704982708045 8.885491845797675e-09 8.051318527340523 -0.47009531268048155 SKS(ph)PTISDK ddPTM_A459_Selumetinib_30min_R2 1 SKSPTISDK 9 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 S(0.017)KS(0.92)PT(0.063)ISDK 122.55 0.028054000000000003 12214000.0 19930.0 15673.0 15104.0 14688.0 15906.0 12496.0 20069.0 32318.0 14650.0 25833.0 True False 18822.37038611128 16875.068703362016 14132.225083991783 12687.469061786727 13907.74607855582 14217.210572606116 21002.248265969076 32412.04002946708 17580.409355200864 25087.134167805325 0.7502798151518756 0.6726582873311225 0.5633256070407543 0.5057360867495474 0.5543776337914208 0.566713219513581 0.837172078942423 1.2919785820359628 0.7007739201140819 1.0 14.614660053244318 -7.447348421749414 4.360430484218892 1.0091795654794447 0.5995601981710359 0.5924234304589151 0.1481202833690723 0.1440402208011728 5.107864389956992 0.06404008623543053 0.04093941728715799 3.569863235590892e-08 7.447348421749414 -0.40961936730840875 SKS(ph)QSSGSSATHPISVPGAR ddPTM_A459_Selumetinib_30min_R1 1 SKSQSSGSSATHPISVPGAR 20 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.054)KS(0.897)QS(0.039)S(0.01)GSSATHPISVPGAR 102.21 0.0003601 24481000.0 2356.1 2974.9 2482.3 3086.9 4145.7 2829.5 3466.9 2268.0 400.94 1079.4 True False 2410.9925458274647 2626.5973250065113 2145.2172942978837 2547.830863289579 3770.7221669827823 2801.0377989804456 3205.3889417827963 2207.8452724977387 680.3658965010122 1217.9515042463609 1.9795472458645462 2.156569712216733 1.7613322753973628 2.0918984494921378 3.0959542755489387 2.29979419477269 2.631787005153554 1.8127530240737297 0.5586149318170154 1.0 10.250240974576146 -8.104454902758066 3.933567686937456 0.798501851306951 2.2851979072190045 0.7275419734527625 0.3637277486380721 0.12923673510008218 3.415164583863019 0.29217707264308473 0.10152413963528369 7.862218283704429e-09 8.104454902758066 1.4866960559120534 SKS(ph)QSSSNCSNPISVPLRR ddPTM_A459_Selumetinib_30min_R2 2 SKSQSSSNCSNPISVPLRR 19 2 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.104)KS(0.537)QS(0.139)S(0.104)S(0.104)NCS(0.009)NPIS(0.001)VPLRR;S(0.341)KS(0.515)QS(0.045)S(0.063)S(0.029)NCS(0.007)NPISVPLRR 76.04899999999998 0.01009 29171000.0 60379.0 64213.0 57711.0 63727.0 57878.0 45495.0 38821.0 46067.0 29288.0 57272.0 True False 57023.37689628762 69137.9306226622 53997.93709098581 55047.272664793265 50606.84820411501 51761.5232875092 40626.25342235217 46201.047343197606 35146.41837509374 55618.40854947343 1.0252608512802817 1.2430763918957326 0.9708644763352733 0.9897311717545436 0.909893855720439 0.9306545195637255 0.7304461684878037 0.8306790601910348 0.6319206049168138 1.0 15.763274843927856 -6.183291831839546 0.812753229835135 0.7887344320575128 1.134032784066816 0.5247012754789477 0.11031376921819594 0.4954841804032151 0.6925047889686923 0.05558272795530534 0.1044374072515362 6.557045060194892e-07 6.183291831839546 0.34529835200930326 SKS(ph)YNTPLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R1 3 SKSYNTPLLNPVQEHEAEGAAAGGTSIR 28 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.055)KS(0.595)Y(0.001)NT(0.348)PLLNPVQEHEAEGAAAGGTSIR;S(0.159)KS(0.489)Y(0.091)NT(0.261)PLLNPVQEHEAEGAAAGGTSIR;S(0.164)KS(0.637)Y(0.135)NT(0.064)PLLNPVQEHEAEGAAAGGTSIR 126.31 1.9673e-12 43827300.0 2446.33 2864.89 3960.37 4076.88 3588.36 3202.13 3244.98 2672.38 1791.8 2801.2799999999997 True False 2503.3247292704464 2529.467346948772 3422.573506755228 3364.929440515734 3263.7934715764145 3169.9194795014155 3000.2085460516128 2601.49980128638 3040.553732105834 3160.8515747778793 0.7919779433004098 0.800248694729212 1.0828010824885825 1.0645642039525995 1.0325677730710179 1.0028688169972593 0.9491772944961658 0.8230376339228119 0.9619413187155115 1.0 11.62609757635519 -5.239673248202581 23.39610130790381 0.9865389234591774 0.7961131516878295 0.561708776576188 0.0683291162445247 298.75521797676515 321124.25794312713 0.019977255342557558 0.052715586730692814 5.75873046189202e-06 5.239673248202581 -0.1904257717713479 SKS(ph)YNTPLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R2 1 SKSYNTPLLNPVQEHEAEGAAAGGTSIR 28 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.107)KS(0.31)Y(0.273)NT(0.31)PLLNPVQEHEAEGAAAGGTSIR 56.234 0.0041597000000000005 12140000.0 20144.0 16259.0 19464.0 21503.0 26680.0 15181.0 21844.0 16780.0 14621.0 22425.0 True False 19024.477122821147 17506.01301907504 18211.70743080086 18574.254305255992 23328.219877773736 17272.044950602864 22859.789283064838 16828.827021921457 17545.608544873172 21777.53198285273 0.8735827888027305 0.803856609319136 0.8362613102871554 0.8529090587437113 1.0712058600644916 0.7931130563464486 1.0496960491695873 0.7727609829787966 0.8056747917389488 1.0 14.410552844263119 -6.021406601410889 24.851683621108755 0.9098653236838903 0.8361773856849133 0.11586972456770661 0.09971751263965464 1661.55927929364 1928962.4961858643 0.02889730541076675 0.03770093684846865 9.519045409779121e-07 6.021406601410889 -0.073687937998977 SKSDAT(ph)ASISLSSNLK ddPTM_A459_Selumetinib_30min_R1 1 SKSDATASISLSSNLK 16 1 Q9UBF8-2;A0A0B4J1S8;Q9UBF8 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 SKS(0.087)DAT(0.906)AS(0.007)ISLSSNLK 255.23 4.1449999999999996e-29 24900000.0 1234.6 1403.9 1115.3 1170.9 1158.8 1297.6 1234.6 1440.3 605.09 948.64 True False 1263.3637778865861 1239.5307353445974 963.8483859043748 966.4242955151676 1053.9867446027572 1284.5473221265343 1141.473128017837 1402.0985652462502 1026.7935359749529 1070.407184536101 1.180264665762786 1.1579992672431398 0.9004502210269568 0.9028566974109034 0.984659632174965 1.200054839582601 1.0663915045679881 1.309874023177357 0.9592550861100118 1.0 10.063943989105947 -6.7467627148701474 24.984317034927166 1.1239370053401085 1.0188887502364465 0.08633560832966902 0.12657614415509408 507.17852643210233 863376.2499583347 0.04304815251250017 0.04287303080923665 1.7915844532421604e-07 6.7467627148701474 -0.105048255103662 SKSEDMDNVQS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 SKSEDMDNVQSK 12 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 S(0.006)KS(0.386)EDMDNVQS(0.608)K 106.88 0.041373 14943000.0 37597.0 32266.0 31373.0 34102.0 41464.0 33301.0 33703.0 30711.0 27049.0 40188.0 True False 35507.50925271577 34740.698448457784 29354.495336339674 29457.248770768747 36254.92162713682 37887.91047362007 35270.256281227565 30800.363925520236 32459.555812206723 39027.66801903616 0.9098035074859355 0.8901556309106822 0.7521457680233856 0.7547786036409007 0.9289543410447454 0.970796165816001 0.903724410693053 0.7891930389101658 0.8317062601940303 1.0 15.252209640997005 -6.283004352085826 24.931024721361318 0.8968418130579028 0.8259251250691964 0.204295936178445 0.0739504623785316 1538.7268826729787 1778899.7747958198 0.025173077575332086 0.02856671741890378 5.211894882140601e-07 6.283004352085826 -0.07091668798870643 SKSEEAHAEDSVMDHHFR ddPTM_A459_Selumetinib_30min_R2 1 SKSEEAHAEDSVMDHHFR 18 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 36.127 0.045889 5632800.0 47302.0 52811.0 65108.0 80810.0 77028.0 48096.0 35838.0 45318.0 28395.0 78498.0 False True 44673.14420490895 56861.433885870654 60919.022164230475 69803.53859497442 67351.05400094292 54720.78742798203 37504.53801164977 45449.86787720125 34074.793422588984 76231.55877770226 0.5860190309787533 0.7459041215683843 0.7991312671681757 0.9156777024398453 0.883506189311232 0.7178232782508426 0.4919817804200516 0.5962080351752606 0.44699064231329694 1.0 16.21810075609305 -7.009445136614385 20.556317721115803 0.6008251222124639 0.7926379938045104 0.1513791487555397 0.16223046350603534 63.658333083349234 138546.51284224587 0.05778004070799202 0.04809498918257457 9.78486556849183e-08 7.009445136614385 0.19181287159204652 SKSERPPTILMTEEPSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SKSERPPTILMTEEPSSPK 19 2 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 SKSERPPTILMT(0.025)EEPS(0.136)S(0.839)PK 63.125 0.033297 5001200.0 19276.0 12915.0 17155.0 14945.0 10361.0 13719.0 16280.0 15562.0 9509.6 14967.0 True False 18204.717087941837 13905.538971729758 16051.265976951743 12909.465218437012 9059.35855148478 15608.66772131749 17037.052258208005 15607.28284357221 11411.785720424446 14534.863821063844 1.2524862504428602 0.9567023910865906 1.1043286111625166 0.8881724230349297 0.6232847216880015 1.0738778094843582 1.1721508001690393 1.0737825297650345 0.7851319324978161 1.0 13.827229934298714 SKSISS(ph)SNPDLAVAPGSVDDEVSR ddPTM_A459_Selumetinib_30min_R1 1 SKSISSSNPDLAVAPGSVDDEVSR 24 1 K7ESB7;K7EKT0;K7EP20;Q96HP0 K7ESB7;Q96HP0 DOCK6 Dedicator of cytokinesis protein 6 1 S(0.239)KS(0.087)IS(0.141)S(0.392)S(0.141)NPDLAVAPGSVDDEVSR 130.62 6.3474e-08 8337600.0 2256.9 2625.7 3267.4 3696.9 3134.1 2889.7 2933.9 3117.9 1573.0 2176.4 True False 2309.4813788370625 2318.2818233451867 2823.7050265434887 3051.305814407739 2850.6212083702976 2860.6322416376734 2712.593560903559 3035.2031636334655 2669.2661126255607 2455.762139931237 0.9404336606075903 0.9440172505510245 1.1498283895778907 1.242508696095941 1.1607888085000435 1.1648653569183915 1.1045831828727164 1.2359516071529848 1.0869400049877396 1.0 11.261955115663357 -5.263151661429987 6.904731279905364 1.1554344844074673 0.9411390886817544 0.5816904880509098 0.06754670635757026 0.07458476012993519 24.21977197019586 0.01643327078149109 0.03864112527785775 5.4556730843517485e-06 5.263151661429987 -0.21429539572571288 SKSQEEPKDT(ph)FEHDPSESIDEFNK ddPTM_A459_Selumetinib_30min_R2 1 SKSQEEPKDTFEHDPSESIDEFNK 24 2 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.297)KS(0.297)QEEPKDT(0.407)FEHDPSESIDEFNK 74.36399999999998 0.00059266 5351400.0 68192.0 57741.0 60283.0 59075.0 54547.0 50425.0 60604.0 59996.0 36971.0 63646.0 True False 64402.16163420478 62169.54903342221 56404.45741116773 51028.88308994084 47694.318203632836 57370.586037425026 63422.20608454778 60170.578427127504 44366.23305604991 61808.374607832535 1.041964977122106 1.0058434545137498 0.9125698219545154 0.8255982043487408 0.7716481545785363 0.928200853062958 1.02611023970384 0.9735020344557405 0.7178029407430444 1.0 15.91551470613603 -5.2341761725706855 3.278124582112804 0.8913824349691731 1.0332972777982081 0.2407426364447679 0.09331683525268503 0.37022220478997714 8.169044888038215 0.026029458516964928 0.07741133039638645 5.8320847640238895e-06 5.2341761725706855 0.141914842829035 SKSYNT(ph)PLLNPVQEHEAEGAAAGGTSIR ddPTM_A459_Selumetinib_30min_R2 1 SKSYNTPLLNPVQEHEAEGAAAGGTSIR 28 1 P85299;P85299-5;P85299-2;P85299-4;P85299-3 P85299 PRR5 Proline-rich protein 5 1 S(0.044)KS(0.288)Y(0.235)NT(0.433)PLLNPVQEHEAEGAAAGGTSIR 87.53200000000002 3.5065e-05 12853000.0 21088.0 23534.0 28515.0 26538.0 32534.0 21443.0 18970.0 19691.0 17692.0 26535.0 True False 19916.013381952554 25338.982126263098 26680.375944784537 22923.47861939655 28446.78806234973 24396.57860982659 19852.142588341885 19748.29754997946 21230.894355782526 25768.86560379029 0.7728711728397989 0.9833177182054936 1.0353725443335067 0.8895804329091141 1.1039208516096086 0.946746317239442 0.7703925696062411 0.7663627050418053 0.823897127728421 1.0 14.65334140786811 -7.182241062461456 6.553426498065306 0.8210491511521418 0.9648920524678322 0.22204977054392527 0.10244311438032466 0.3026199309081594 20.814818662862134 0.03858157755457744 0.02975670776897747 6.572928945974444e-08 7.182241062461456 0.14384290131569033 SKT(ph)FDWAEFRPIQQALAQER ddPTM_A459_Selumetinib_30min_R1 1 SKTFDWAEFRPIQQALAQER 20 2 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 S(0.074)KT(0.926)FDWAEFRPIQQALAQER 78.45100000000002 0.015872999999999998 151480000.0 1287.5 2118.8 2089.3 2223.6 1730.6 1496.2 1651.7 1729.1 1076.7 1407.4 True False 1317.4962449611057 1870.7299109966048 1805.5845357034077 1835.2900021415376 1574.0675355622463 1481.1495864409053 1527.1109392087014 1683.2386510916408 1827.0812609433813 1588.0534992369155 0.8296296350180792 1.1780018191424406 1.136979665087492 1.1556852480243411 0.9911930147936517 0.9326824235786898 0.9616243658935307 1.0599382526473216 1.1505161896758027 1.0 10.633043800281296 -6.288612496681683 24.298825076431424 1.0121053842607415 1.0868479234911066 0.06425455596151908 0.10611682171343352 1308.8480518001177 1170398.7609965375 0.0337365322190867 0.03826522814765121 5.145025165270089e-07 6.288612496681683 0.07474253923036511 SKT(ph)PPPPPQTAQTK ddPTM_A459_Selumetinib_30min_R1 2 SKTPPPPPQTAQTK 14 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.113)KT(0.887)PPPPPQTAQTK;S(0.243)KT(0.757)PPPPPQTAQTK 142.19 0.0056806 55423800.0 6598.700000000001 7277.0 7773.5 8088.5 6523.6 6610.4 6567.2 6867.2 3352.6 6026.4 True False 6752.436871164932 6425.00545701448 6717.901396779033 6675.995314949551 5933.541531835128 6543.905377762979 6071.8308167169425 6685.05954819069 5689.117335784139 6799.94714210697 0.9930131411393123 0.944861088291296 0.9879343554275755 0.98177164843093 0.872586419840407 0.9623465066723068 0.8929232374643988 0.9831046342691596 0.8366414057185392 1.0 12.731307816596162 -6.213849013097161 24.982754977776665 0.9240590035767067 0.9753954630378114 0.2186149810086585 0.04839490347038861 606.6353412525366 318455.3493209411 0.013116251883066485 0.01693298012208102 6.111544620529066e-07 6.213849013097161 0.051336459461104766 SKT(ph)PPPPPQTAQTK ddPTM_A459_Selumetinib_30min_R2 1 SKTPPPPPQTAQTK 14 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 S(0.237)KT(0.763)PPPPPQTAQTK 101.45 0.011461 41187000.0 168900.0 133630.0 181760.0 199380.0 172060.0 138350.0 201540.0 174570.0 111560.0 181150.0 True False 159513.2141602705 143878.99131182715 170065.75948532496 172224.10005031578 150444.2845640837 157406.4566837434 210912.00934393378 175077.9697983806 133875.11724684 175919.72881577592 0.9067386315000154 0.8178672868606909 0.9667236337285328 0.9789925280675585 0.8551871104896357 0.8947629566242697 1.1989104960751842 0.9952150959812085 0.7610011574485471 1.0 17.424557759797146 SKTPS(ph)SPCPASK ddPTM_A459_Selumetinib_30min_R2 2 SKTPSSPCPASK 12 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 SKT(0.032)PS(0.484)S(0.484)PCPASK;S(0.004)KT(0.004)PS(0.76)S(0.233)PCPASK 119.96 0.009094 41490400.0 218614.0 246286.0 247913.0 334099.0 354378.0 260021.0 218388.0 288717.0 261840.0 268597.0 True False 206464.3090611808 265175.3442656937 231962.54748726555 288594.1398470785 309857.86746048374 295836.53251437395 228543.4747276122 289557.1186703278 314215.316420874 260841.90671118395 0.791530439507895 1.0166132720357235 0.8892840510635626 1.1063948407899926 1.1879144396976538 1.134160289826196 0.8761762157361698 1.1100866510339484 1.2046197652158228 1.0 17.992816145184953 -5.7625005999193935 24.999621657917956 1.0902664395129338 0.9108896289454999 0.4160132763934554 0.10250123203166978 29.648665601577726 698478.4994893064 0.02924327905069796 0.046310015639526934 1.7278235937503947e-06 5.7625005999193935 -0.17937681056743393 SKTPSS(ph)PCPASK ddPTM_A459_Selumetinib_30min_R1 2 SKTPSSPCPASK 12 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 SKT(0.001)PS(0.027)S(0.973)PCPASK;SKT(0.003)PS(0.028)S(0.969)PCPASK 201.3 0.0003862 30153000.0 11132.9 11787.0 14149.6 16603.300000000003 11231.0 10309.9 10919.099999999999 10517.599999999999 5592.9 8569.3 True False 11392.27490914756 10406.972560372362 12228.162038189314 13703.84533754119 10215.158032994093 10206.191766640217 10095.46349598216 10238.639082020376 9490.742810746016 9669.253127050526 1.1781959536540356 1.0762953894813245 1.264643905533927 1.4172599638749308 1.0564578151766815 1.0555305184934667 1.0440789338464287 1.058886239452864 0.9815383552422355 1.0 13.239188741942916 -6.486308799701265 24.737524779223726 1.0352808355876004 1.226490226819723 0.5893662199227512 0.08241194367064955 413.0865376265771 279430.0740460329 0.02749825096687777 0.03116969829390442 3.263556984852674e-07 6.486308799701265 0.19120939123212266 SKTPT(ph)GPELDTSYK ddPTM_A459_Selumetinib_30min_R2 1 SKTPTGPELDTSYK 14 1 Q8NF91;Q8NF91-4;A0A0C4DG40;E7ENN3;Q8NF91-2;A0A5F9ZHE1;A0A5F9ZH87;H0Y325;F8WAI0;Q5JV20;Q8NF91-9;H0Y326;Q8NF91-3;Q8NF91-11;Q8NF91-8;A0A5F9ZH86 Q8NF91 SYNE1 Nesprin-1 1 S(0.001)KT(0.242)PT(0.754)GPELDT(0.003)SYK 116.51 0.027359 6855800.0 36435.0 25764.0 31230.0 34249.0 27650.0 27103.0 38120.0 27974.0 25744.0 30634.0 True False 34410.08856086123 27740.015955682946 29220.695800653055 29584.2271171796 24176.359805863714 30836.192233462196 39892.65553334702 28055.399708655004 30893.519347460147 29749.516823309288 1.1566604178895536 0.9324526552965101 0.9822242147394511 0.9944439532543876 0.8126639484417137 1.0365274977945684 1.3409513764637144 0.9430539620284888 1.0384544909063704 1.0 14.860578616633012 -6.996758436929885 24.999913710468604 1.0919937413099363 0.9696823908483687 0.13215787446111127 0.12540507210970878 178.37292473989214 1375650.2311938554 0.04439482019875426 0.038947425011772584 1.0074918996968433e-07 6.996758436929885 -0.1223113504615676 SKVGST(ph)ENIK ddPTM_A459_Selumetinib_30min_R2 1 SKVGSTENIK 10 1 E7EVA0;H0Y2V1;H7C4C5;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 S(0.067)KVGS(0.334)T(0.599)ENIK 124.3 0.040249 52781000.0 148920.0 129820.0 154490.0 148020.0 138820.0 95151.0 107900.0 131610.0 90371.0 140650.0 True False 140643.62257399343 139776.77656290788 144550.28159599358 127859.42065125785 121380.19053345402 108257.18655522121 112917.56379979383 131992.9633107915 108447.72517671408 136589.0690474127 1.0296843192127865 1.0233379401274685 1.0582858687309553 0.9360882356323506 0.888652301241768 0.7925757698637148 0.8266954638998086 0.9663508524607793 0.793970746949522 1.0 17.059482506658554 -5.981075065598312 2.764262715609439 0.8698634284900751 1.0360161493052353 0.5461529304583589 0.06430433070122933 0.19325052521459005 2.9986839041935065 0.019055956486170027 0.028917466641608165 1.0445396602348748e-06 5.981075065598312 0.1661527208151602 SKVSSSSGTTPFSSAAALPPGSYAS(ph)LGR ddPTM_A459_Selumetinib_30min_R1 2 SKVSSSSGTTPFSSAAALPPGSYASLGR 28 1 H0Y5T1;Q7Z460-2;Q7Z460-3;Q7Z460 H0Y5T1;Q7Z460 CLASP1 CLIP-associating protein 1 1 SKVSSSSGTTPFSSAAALPPGS(0.1)YAS(0.9)LGR;SKVSSSSGTTPFSSAAALPPGS(0.223)YAS(0.777)LGR 148.56 2.3228e-14 38973000.0 5181.4 4796.0 10704.4 11056.5 6127.7 6179.4 5258.7 4974.4 3263.24 3465.2 True False 5302.116538750655 4234.482090400089 9250.801275060336 9125.689831209702 5573.450616933303 6117.240846446285 4862.032025196341 4842.4627528715855 5537.479942380312 3909.9921739063248 1.3560427496849723 1.082989914573046 2.365938565503115 2.3339406897309902 1.425437793489259 1.5645148569018188 1.243488940372704 1.2384840013717124 1.4162381140645677 1.0 11.932950004553325 -6.9233985986554 1.8783415918216266 1.245833630601827 1.7623341388033058 0.26576817636341965 0.3870925175561753 0.542134452783668 3.897257152856702 0.18760462623136967 0.15267134372908378 1.1928927561758326e-07 6.9233985986554 0.5165005082014789 SKYDEIFYNLAPADGKLS(ph)GSK ddPTM_A459_Selumetinib_30min_R1 1 SKYDEIFYNLAPADGKLSGSK 21 2 Q9NZN4;Q9NZN4-2 Q9NZN4 EHD2 EH domain-containing protein 2 1 SKYDEIFYNLAPADGKLS(0.716)GS(0.284)K 69.07 0.0028345 374970000.0 5640.5 6245.0 7589.4 7913.0 5860.5 6455.4 5766.5 5670.0 3587.4 5117.3 True False 5771.912675497562 5513.832496778263 6558.801165590119 6531.143095406536 5330.4188097553115 6390.464537034238 5331.528262364212 5519.613181244351 6087.5557866706495 5774.1553017230835 0.999611609645336 0.954915863647253 1.1358892899248634 1.1310993130817866 0.9231512716959042 1.1067358259531468 0.9233434128058895 0.9559169944038787 1.0542764211509938 1.0 12.495394195494146 -7.266886015391335 24.95132461983694 0.9797106285528661 1.0408756931279342 0.13088099594352143 0.07360123585235627 983.408650391956 4505025.661256436 0.031040332152277694 0.021535140303922725 5.4089626755194826e-08 7.266886015391335 0.061165064575068095 SKYDEIFYNLAPADGKLS(ph)GSK ddPTM_A459_Selumetinib_30min_R2 1 SKYDEIFYNLAPADGKLSGSK 21 2 Q9NZN4;Q9NZN4-2 Q9NZN4 EHD2 EH domain-containing protein 2 1 SKYDEIFYNLAPADGKLS(0.683)GS(0.317)K 69.256 0.0027778000000000004 14425000.0 135080.0 132540.0 133920.0 138390.0 133630.0 116430.0 144320.0 140740.0 100020.0 140630.0 True False 127572.79436808394 142705.3918167298 125303.733001071 119541.04326393396 116842.20473264257 132467.17565369143 151031.1659646548 141149.53009923873 120026.79479229945 136569.6464993789 0.9341226080471997 1.0449275917059564 0.9175079251716513 0.8753119476257677 0.8555503197643113 0.9699605955580611 1.105891168615873 1.0335351501395347 0.8788687520901309 1.0 17.059277345247388 -6.9996250513392635 24.99999276700801 1.0117337259379713 0.9272759725739593 0.21935473254964333 0.06997194546414644 20.58022199357389 1372100.5072451846 0.026463967526270803 0.02312907228346601 1.0008637239917711e-07 6.9996250513392635 -0.08445775336401196 SLAALDALNT(ph)DDENDEEEYEAWK ddPTM_A459_Selumetinib_30min_R1 3 SLAALDALNTDDENDEEEYEAWK 23 0 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 SLAALDALNT(1)DDENDEEEYEAWK;SLAALDALNT(1)DDENDEEEYEAWK;SLAALDALNT(0.993)DDENDEEEY(0.007)EAWK 173.34 1.153e-12 43232300.0 11843.6 13159.5 13895.7 14874.4 12304.600000000002 11626.1 12530.7 12097.5 7330.3 9602.6 True False 12119.532836366088 11618.779622314421 12008.740263616448 12276.865267068753 11191.65110255358 11509.1519896542 11585.499210475551 11776.63500178192 12438.983716070656 10835.187247244852 1.1185346925543733 1.07231922782588 1.1083094356924938 1.1330552012555655 1.032898725898749 1.062201485496314 1.0692477154394804 1.086888000461317 1.1480174206711207 1.0 13.403436464991866 -6.250726540790935 24.984073530121336 1.070804861269723 1.105520307315862 0.21298751873143784 0.03845091667774392 1353.9281537661643 3157584.2506444957 0.011435693459107638 0.014610166507155506 5.614013584836427e-07 6.250726540790935 0.034715446046138965 SLAALDALNT(ph)DDENDEEEYEAWK ddPTM_A459_Selumetinib_30min_R2 2 SLAALDALNTDDENDEEEYEAWK 23 0 P55081 P55081 MFAP1 Microfibrillar-associated protein 1 1 SLAALDALNT(0.998)DDENDEEEY(0.002)EAWK;SLAALDALNT(1)DDENDEEEYEAWK 91.599 0.00019506 1828500.0 54960.2 54016.0 56814.2 60066.5 58211.2 43694.2 42847.6 47238.1 39602.9 54591.1 True False 51905.732107112504 58158.853511185014 53158.83622662382 51885.339079507925 50898.18864126921 49712.679433544006 44840.09830090866 47375.555050311545 47524.586597480215 53014.91309828816 0.9790779438019777 1.0970281777763198 1.0027147668443561 0.9786932779332103 0.9600730373150927 0.9377112312035313 0.8458015995947475 0.8936269491280424 0.896438074120219 1.0 15.694110626519022 -6.254928691751251 1.1777338985362515 0.9021623406864875 1.0365943570584926 0.514273421848062 0.04669526887566879 0.33706325264222153 0.9629609332192213 0.018879732699655354 0.02793125135805616 5.559955405246129e-07 6.254928691751251 0.13443201637200508 SLAASSPPPCS(ph)QPSQCPEEKPQESSPMK ddPTM_A459_Selumetinib_30min_R2 2 SLAASSPPPCSQPSQCPEEKPQESSPMK 28 1 Q7Z6J9 Q7Z6J9 TSEN54 tRNA-splicing endonuclease subunit Sen54 1 S(0.002)LAAS(0.093)S(0.087)PPPCS(0.754)QPS(0.064)QCPEEKPQESSPMK;S(0.004)LAAS(0.033)S(0.098)PPPCS(0.865)QPS(0.002)QCPEEKPQESSPMK 89.39200000000002 1.0377e-05 21846700.0 101414.0 86980.0 99665.0 105596.0 102893.0 80065.0 86489.0 94442.0 76707.0 91929.0 True False 95777.81587240782 93651.08631521916 93252.6624070473 91213.64263673955 89966.66146490909 91093.22699229422 90510.9098747022 94716.81058428522 92050.54337265503 89274.7709097735 1.0728430316467201 1.0490207408078216 1.0445578460379819 1.0217180252293852 1.0077501241177629 1.0203692046923152 1.0138464535089988 1.0609583157599114 1.0310924624571356 1.0 16.445964906229648 -5.141136069797623 1.3893274076337712 1.0240401737508562 1.075144541595611 0.5022656253555978 0.015990349644770068 0.6505451709657726 1.760837303840436 0.0051062454482352655 0.038753017588562075 7.225433864130814e-06 5.141136069797623 0.051104367844754695 SLAGSS(ph)GPGASSGTSGDHGELVVR ddPTM_A459_Selumetinib_30min_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;E9PPR1;E9PMW7;E9PIZ1;H0YCK7 P29692 EEF1D Elongation factor 1-delta 1 S(0.013)LAGS(0.072)S(0.44)GPGAS(0.368)S(0.106)GT(0.001)SGDHGELVVR 61.597 0.0043565 8796200.0 4700.0 6210.7 7633.5 7628.8 6994.2 6514.1 6521.9 6150.1 4023.4 4971.6 True False 4809.500855391998 5483.548356723902 6596.9126278140775 6296.573290311813 6361.575844926308 6448.574068329576 6029.9478321881825 5986.979369659769 6827.415942490574 5609.753287484901 0.8573462341243724 0.977502588029574 1.1759719705555471 1.1224331922687536 1.13402060998274 1.149528996705799 1.0749042824469155 1.0672446831158229 1.217061712450389 1.0 12.45372160830387 -5.014373133432724 3.3427720858481496 1.1199986497879417 0.8653736481604966 0.6766333333008315 0.05803641052047273 0.1289576771967193 2.8883364293804115 0.01433231115766039 0.06289675516085014 9.674462968197725e-06 5.014373133432724 -0.25462500162744517 SLAGSSGPGASSGTS(ph)GDHGELVVR ddPTM_A459_Selumetinib_30min_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 P29692;E9PI39;E9PQ49;E9PK01;P29692-2;E9PRY8;A0A087X1X7;E9PL12;E9PPR1;E9PMW7;E9PIZ1;H0YCK7 P29692 EEF1D Elongation factor 1-delta 1 SLAGSSGPGASSGT(0.076)S(0.923)GDHGELVVR 137.28 2.9668000000000003e-07 0.0 1343.8 1556.5 1371.5 1751.2 1461.5 964.72 1188.0 1172.0 732.19 1305.5 True False 1375.1079254203758 1374.2642564027806 1185.2578331102386 1445.385794095278 1329.3075830487828 955.0157926956763 1098.3882035357133 1140.9147528074745 1242.4729529582387 1473.073641646863 0.933495710291195 0.9329229833115364 0.8046154649710161 0.981204030288241 0.9024040247999054 0.6483150371409743 0.7456437835027311 0.7745130457510309 0.84345610282537 1.0 10.524613839803711 -6.56826052167761 24.9923801216108 0.7837031413260591 0.9111165334334212 0.24111489634397631 0.09351403233026835 156.3505157318208 86103.39107783517 0.029849510597927426 0.029849520730673765 2.7023368180071164e-07 6.56826052167761 0.12741339210736213 SLANS(ph)GGWVPIK ddPTM_A459_Selumetinib_30min_R2 1 SLANSGGWVPIK 12 0 Q9Y6R9-2;Q9Y6R9 Q9Y6R9-2 CCDC61 Coiled-coil domain-containing protein 61 1 S(0.001)LANS(0.999)GGWVPIK 98.902 0.014858 2600200.0 14537.0 12814.0 16097.0 17130.0 17196.0 13059.0 12003.0 14232.0 12596.0 14507.0 True False 13729.091736221748 13796.792596495941 15061.336545088448 14796.864449101768 15035.684745809504 14857.75871220096 12561.163283493283 14273.412763765566 15115.551961645746 14088.145216287385 0.9745137862682922 0.979319306032237 1.0690787405907736 1.0503060709507046 1.0672579331753809 1.0546284471162195 0.8916122804420876 1.013150598935053 1.0729270411104628 1.0 13.782194064766609 -9.869143424072627 15.294472201800886 0.9999989227562606 1.0189334115031206 0.010985566344138165 0.05459853165228035 0.0 0.0 0.055886516727226526 0.013554471265541367 1.351626120182726e-10 9.869143424072627 0.01893448874685999 SLAPDRS(ph)DDEHDPLDNTSRPR ddPTM_A459_Selumetinib_30min_R1 2 SLAPDRSDDEHDPLDNTSRPR 21 2 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(0.003)LAPDRS(0.996)DDEHDPLDNTSRPR;S(0.014)LAPDRS(0.986)DDEHDPLDNTSRPR 93.427 0.00020238 101697000.0 5006.7 6978.1 7484.5 7369.1 7249.2 5909.799999999999 6926.799999999999 5950.9 3135.0 5076.0 True False 5123.346368657681 6161.100807969324 6468.146009415667 6082.2250201390525 6593.511139950213 5850.352777669073 6404.305899201328 5793.062800752559 5319.866028659332 5727.554044427018 0.8945086033090793 1.0756949232044615 1.1293033569380728 1.0619236366799776 1.1511914315964913 1.0214399955529951 1.118157218513337 1.011437475022917 0.9288198744864972 1.0 12.483703451331975 -7.9856156986249385 6.933089587988111 0.965864758333535 1.068983084088869 0.25321511783801975 0.06939501549128259 0.181026060807152 41.6806228474088 0.03952267666569971 0.017942349465884348 1.0336756869663004e-08 7.9856156986249385 0.10311832575533397 SLAPDRS(ph)DDEHDPLDNTSRPR ddPTM_A459_Selumetinib_30min_R2 7 SLAPDRSDDEHDPLDNTSRPR 21 2 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(0.297)LAPDRS(0.703)DDEHDPLDNTSRPR;SLAPDRS(1)DDEHDPLDNTSRPR;S(0.003)LAPDRS(0.997)DDEHDPLDNTSRPR;SLAPDRS(1)DDEHDPLDNTSRPR;S(0.263)LAPDRS(0.737)DDEHDPLDNTSRPR;SLAPDRS(1)DDEHDPLDNTSRPR;SLAPDRS(1)DDEHDPLDNTSRPR 180.68 2.8692e-14 385851700.0 346802.0 315057.0 380849.0 411710.0 390710.0 279717.0 278491.0 310989.0 260439.0 351281.0 True False 327528.1331984027 339220.85883207596 356345.5899770387 355634.3877606352 341625.51680828223 318245.47773188754 291441.38331944775 311893.9265029993 312534.0772736624 341138.6047923514 0.9601028104039022 0.9943783965422419 1.0445771453921013 1.0424923557892465 1.0014273143206034 0.9328920071230321 0.8543195616832812 0.9142733250399698 0.9161498372894489 1.0 18.37999850054326 -6.790815237431152 3.910322757215473 0.9117868402380669 1.012695380083853 0.5234556263285697 0.04025586930416176 0.15922865333863143 5.2368277892060275 0.01452300373428457 0.013286350451748604 1.6187685663706327e-07 6.790815237431152 0.10090853984578607 SLAQVEEPAIENVKPPGS(ph)PVAK ddPTM_A459_Selumetinib_30min_R1 2 SLAQVEEPAIENVKPPGSPVAK 22 1 Q9NXL9-4;Q9NXL9 Q9NXL9-4 MCM9 DNA helicase MCM9 1 SLAQVEEPAIENVKPPGS(1)PVAK;SLAQVEEPAIENVKPPGS(1)PVAK 103.27 4.8733e-05 56698000.0 5107.4 6584.200000000001 7262.6 7918.8 5845.2 5872.2 6098.5 6025.2 3954.0 5251.700000000001 True False 5226.392482729593 5813.318803088465 6276.378810606216 6535.930234286022 5316.502692053875 5813.130999531002 5638.485235069485 5865.3921233921465 6709.649211266026 5925.806850889947 0.8819714537176799 0.9810172604959967 1.059160206962132 1.1029603898251334 0.8971778570972887 0.9809855680088488 0.9515135030468784 0.9898048098734897 1.13227605625694 1.0 12.532795887707064 -8.119236057376686 9.097083307337499 1.0657932726413697 0.9831278700883693 0.19761552318833076 0.06893512498545276 0.5695361269752652 40.324531207088484 0.04794899419347708 0.018062059109466757 7.599131198197813e-09 8.119236057376686 -0.08266540255300037 SLAQVEEPAIENVKPPGS(ph)PVAK ddPTM_A459_Selumetinib_30min_R2 2 SLAQVEEPAIENVKPPGSPVAK 22 1 Q9NXL9-4;Q9NXL9 Q9NXL9-4 MCM9 DNA helicase MCM9 1 SLAQVEEPAIENVKPPGS(1)PVAK;SLAQVEEPAIENVKPPGS(1)PVAK 107.09 3.2828000000000005e-05 18314400.0 65828.0 71281.0 69044.0 72807.0 78193.0 58623.0 65298.0 62847.0 51599.0 73512.0 True False 62169.54329036285 76748.02349546016 64601.78420942324 62890.561000919544 68369.69628571082 66697.78612339064 68334.48638553226 63029.874365119074 61920.24179651941 71389.51755288623 0.8708497468736484 1.075060122637813 0.9049197476585473 0.8809495169137324 0.9576993742122113 0.9342798272026437 0.9572061659459911 0.8829009709783481 0.8673576166227505 1.0 16.12342463188925 SLASEAPSQPSLNGGS(ph)PEGVESQDGVDHFR ddPTM_A459_Selumetinib_30min_R2 1 SLASEAPSQPSLNGGSPEGVESQDGVDHFR 30 0 P38935 P38935 IGHMBP2 DNA-binding protein SMUBP-2 1 SLASEAPS(0.002)QPS(0.045)LNGGS(0.944)PEGVES(0.01)QDGVDHFR 84.509 1.7393e-06 8774600.0 30816.0 23929.0 30698.0 38083.0 36565.0 29536.0 30458.0 33334.0 29425.0 32658.0 True False 29103.37008622201 25764.277356137925 28722.92410145525 32896.02970316068 31971.377804752527 33604.31589888717 31874.357351382034 33430.996421259224 35310.822203193544 31715.078684325726 0.9176508870086935 0.8123668117800126 0.9056551423802942 1.037236263248453 1.00808130173593 1.059569053363098 1.0050221747403396 1.0541041614309958 1.1133764653292477 1.0 14.952881301015383 -5.693108204432812 3.614937436779259 1.0409366378342635 0.8634274396284344 0.7808689357593288 0.03942727817478974 0.09528455979865232 2.4710287543965728 0.010816397997775489 0.019356270216254995 2.0271775854757836e-06 5.693108204432812 -0.1775091982058291 SLATMDS(ph)PPHQK ddPTM_A459_Selumetinib_30min_R1 1 SLATMDSPPHQK 12 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 SLAT(0.006)MDS(0.994)PPHQK 126.1 0.0027832 3410100.0 1726.1 3103.1 2807.5 3207.1 2653.0 2666.0 2710.3 1993.3 1272.6 1791.0 True False 1766.3147715940686 2739.787609407947 2426.256920493617 2647.040189723028 2413.0366184251934 2639.182460534323 2505.859888924953 1940.4312088490942 2159.5092529734807 2020.8922958173355 0.8740271687164284 1.3557316315562773 1.2005869513755234 1.3098373402687704 1.194045137100816 1.3059490928817286 1.2399769617170397 0.9601853660708329 1.0685919568514572 1.0 10.98077671947683 -7.755837119200533 24.987555358930226 1.0107914793581063 1.2233312910404075 0.3436663322457134 0.12709155659780894 136.5531589190794 609070.9911666316 0.058601934624819454 0.03262102336502561 1.754538412654324e-08 7.755837119200533 0.21253981168230118 SLATMDS(ph)PPHQK ddPTM_A459_Selumetinib_30min_R2 2 SLATMDSPPHQK 12 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 SLAT(0.003)MDS(0.997)PPHQK;SLATMDS(1)PPHQK 91.076 0.015567 28903000.0 138290.0 141122.0 154217.0 153414.0 160361.0 129012.0 140108.0 161033.0 114791.0 154823.0 True False 130604.39541873205 151945.60362125028 144294.84611877427 132518.74854608858 140215.01753447065 146782.23194566753 146623.29961873498 161501.57936955176 137752.40752852292 150352.85771153684 0.8686525644182056 1.010593386344337 0.9597080382443723 0.8813849670907864 0.9325730130350007 0.9762516933817127 0.9751946311525566 1.0741503808288404 0.9161941424007463 1.0 17.197992763479967 -6.958934514266473 2.60224150184448 0.9969885374727318 0.9340007230233374 0.23835587490501098 0.051540986982990346 0.42440450755471953 5.8224846210070575 0.020570552428620128 0.016902353405580776 1.0991715671421941e-07 6.958934514266473 -0.06298781444939439 SLCLS(ph)PSEASQMK ddPTM_A459_Selumetinib_30min_R2 1 SLCLSPSEASQMK 13 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 S(0.48)LCLS(0.513)PS(0.007)EASQMK 201.76 8.8912e-05 6960800.0 28470.0 21499.0 23874.0 38986.0 43830.0 32333.0 36894.0 43859.0 40896.0 22162.0 True False 26887.751374439937 23147.904169819427 22337.972832045816 33676.0395453988 38323.68355482847 36786.577260249156 38609.644104074076 43986.622428751674 49076.34272971299 21522.125476208803 1.2493074350004352 1.0755398761803432 1.037907378466819 1.5647171829113857 1.7806644421431614 1.7092446236740944 1.7939512594494593 2.043786171462284 2.280273980558446 1.0 14.393532941763919 -5.947129017848343 2.8829299263233437 1.8167733195709292 1.1140604159425085 0.45386635089887517 0.31314790154221983 0.21713430080417176 3.6713923362054426 0.09201447532611157 0.14229445338505672 1.1294603308815472e-06 5.947129017848343 -0.7027129036284208 SLDDS(ph)EEDDDEDSGHSSR ddPTM_A459_Selumetinib_30min_R2 1 SLDDSEEDDDEDSGHSSR 18 0 B4DFN3;Q13563-3;Q13563 B4DFN3 PKD2 Polycystin-2 1 S(0.099)LDDS(0.901)EEDDDEDSGHSSR 81.017 0.0071313 1516100.0 3668.1 750.04 3646.2 4666.2 4841.2 2787.5 3694.9 3328.7 5287.4 3964.1 True False 3464.2416865677264 807.5656562412844 3411.607461682393 4030.6555103560227 4233.005175122874 3171.452822594395 3866.720171305454 3338.3859659040513 6345.027742299597 3849.6461330312814 0.8998857471192864 0.20977659461011094 0.8862132631905134 1.0470197444309541 1.0995829301821383 0.8238297009645236 1.0044352227929918 0.867192944634458 1.648210646650633 1.0 11.910510121226956 -5.480747041954258 7.045327668872432 1.0468488916226752 0.5500825736582128 0.3749916014105078 0.2624442358168378 0.23043966271260125 31.441362678589627 0.06599700890462976 0.1353419675071743 3.3056202327999175e-06 5.480747041954258 -0.49676631796446247 SLDDVIKR ddPTM_A459_Selumetinib_30min_R2 1 SLDDVIKR 8 1 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 91.069 0.037049 102210000.0 420370.0 393400.0 417420.0 423680.0 447320.0 280510.0 331010.0 318680.0 260760.0 394220.0 False True 397007.51827444043 423572.5150196273 390563.65165253304 365974.0531112341 391123.6625084618 319147.7062837504 346402.62088387145 319607.3060396863 312919.286243152 382837.8442934322 1.0370122081508422 1.1064018913840017 1.02018036480526 0.9559505638390531 1.0216431534618056 0.8336367760945141 0.9048285744143038 0.8348372837318512 0.8173676947238006 1.0 18.54637392462601 -6.276698409582295 0.9860274315489039 0.8672080505074252 1.0687279183798222 0.5770749678270926 0.06202333761067481 0.35787761905959015 0.7367996061148009 0.027984159685568763 0.04309315383986039 5.288123514767185e-07 6.276698409582295 0.20151986787239695 SLDGAAAVDSADRS(ph)PRPTSAPAITQGQVAEGGVLDASAK ddPTM_A459_Selumetinib_30min_R1 2 SLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAK 39 2 P11171;Q4VB86;A0A2U3TZH6;A0A3B3IU06;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8YCW8;A0A2R8Y6G5;A0A2R8YFR9;A0A2R8Y4N6;A0A2R8YD30;A0A3B3IUD6;A0A2R8Y7Y3;A0A2R8Y7N0;A0A2R8Y420;A0A3B3ITP0;P11171-3;P11171-4;P11171-7;P11171-6;P11171-5;P11171-2 P11171 EPB41 Protein 4.1 1 S(0.115)LDGAAAVDS(0.204)ADRS(0.543)PRPT(0.063)S(0.063)APAIT(0.01)QGQVAEGGVLDASAK;S(0.161)LDGAAAVDS(0.112)ADRS(0.26)PRPT(0.217)S(0.217)APAIT(0.032)QGQVAEGGVLDASAK 47.808 0.0028876 33464000.0 3030.8 2280.07 2793.0099999999998 2659.21 2722.18 2454.42 2290.79 2893.71 1678.5700000000002 2247.24 True False 3101.4117430897986 2013.1183444242138 2413.7345829057454 2194.8288930539647 2475.959299639913 2429.7307632350553 2117.993865974391 2816.9594107052194 2848.4106920978297 2535.6951439712725 1.2231011880365597 0.7939118190964287 0.9519025142452578 0.8655728581064911 0.9764420243997453 0.9582109146723918 0.8352714919259973 1.1109219566092814 1.123325372480226 1.0 11.308165591370367 -7.781483281282982 24.995535771260215 1.0878428347322509 0.9368953197402227 0.22430098561529344 0.11380858636247725 325.0725004001841 405372.42596827756 0.05830179950704581 0.028062872966064963 1.6539284536197744e-08 7.781483281282982 -0.1509475149920282 SLDGAAAVDSADRS(ph)PRPTSAPAITQGQVAEGGVLDASAK ddPTM_A459_Selumetinib_30min_R2 2 SLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAK 39 2 P11171;Q4VB86;A0A2U3TZH6;A0A3B3IU06;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8YCW8;A0A2R8Y6G5;A0A2R8YFR9;A0A2R8Y4N6;A0A2R8YD30;A0A3B3IUD6;A0A2R8Y7Y3;A0A2R8Y7N0;A0A2R8Y420;A0A3B3ITP0;P11171-3;P11171-4;P11171-7;P11171-6;P11171-5;P11171-2 P11171 EPB41 Protein 4.1 1 S(0.073)LDGAAAVDS(0.062)ADRS(0.83)PRPT(0.015)S(0.015)APAIT(0.006)QGQVAEGGVLDASAK;S(0.142)LDGAAAVDS(0.09)ADRS(0.633)PRPT(0.057)S(0.057)APAIT(0.021)QGQVAEGGVLDASAK 59.017 5.0167e-05 21280000.0 35286.0 29015.0 29613.0 33662.0 28566.0 25256.1 29475.4 33061.0 27898.0 28605.0 True False 33324.94538104979 31240.35720207038 27707.73182019656 29077.17752981107 24977.283696719824 28734.898522951138 30846.064504397054 33157.202036456816 33478.37953524874 27779.099325284387 1.1996409599470923 1.1245993556614549 0.997430892043974 1.0467285922169973 0.8991394358846485 1.0344071341721575 1.110405493828273 1.1936024868263928 1.2051643267201577 1.0 14.761712203490408 -7.436768437630473 4.155753448439135 1.1501598797644839 1.0448066436734724 0.14102486970092776 0.09028696584362311 0.3819617750496044 11.930516180328109 0.042633908174070805 0.02721666346844012 3.657897758306519e-08 7.436768437630473 -0.10535323609101144 SLDGAEFSRPAS(ph)VSENHDAGPDGDKR ddPTM_A459_Selumetinib_30min_R1 1 SLDGAEFSRPASVSENHDAGPDGDKR 26 2 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.001)LDGAEFS(0.022)RPAS(0.759)VS(0.219)ENHDAGPDGDKR 54.828 0.004495 24109000.0 1736.6 2417.8 1251.2 1523.0 2129.3 1696.5 2649.8 2186.1 775.19 1857.6 True False 1777.0594011646242 2134.722851995275 1081.2939123496396 1257.0366402507466 1936.7051909584495 1679.434750298754 2449.9234526337805 2128.117526546432 1315.4408123624974 2096.0410545562713 0.8478170774860252 1.0184546945561581 0.5158743956847486 0.599719474729878 0.9239824700706767 0.8012413433639961 1.168833715021114 1.0153033605522346 0.6275835148853867 1.0 11.033451259469073 -6.376076645826811 9.890768526301985 0.9304376956087168 0.7486619162720476 0.1826241235233036 0.18338217933462903 0.7342044275881302 58.90661011916664 0.05999684501202897 0.06801883161116938 4.206523836121114e-07 6.376076645826811 -0.18177577933666922 SLDGAEFSRPAS(ph)VSENHDAGPDGDKR ddPTM_A459_Selumetinib_30min_R2 3 SLDGAEFSRPASVSENHDAGPDGDKR 26 2 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.002)LDGAEFS(0.04)RPAS(0.594)VS(0.364)ENHDAGPDGDKR;S(0.002)LDGAEFS(0.062)RPAS(0.705)VS(0.23)ENHDAGPDGDKR;SLDGAEFS(0.035)RPAS(0.884)VS(0.081)ENHDAGPDGDKR 55.631 0.0041656 93672000.0 111357.0 58235.0 89951.0 126159.0 115078.0 88445.0 155886.0 145459.0 122505.0 100759.0 True False 105168.2237373904 62701.43724496187 84163.65059124363 108975.92656358592 100620.87282962684 100627.49592622834 163135.00788224908 145882.26160796633 147009.4230756915 97849.82586667794 1.0747921399541773 0.6407925276269132 0.8601308162358718 1.113705881419426 1.0283193857363067 1.0283870720765003 1.667197733233816 1.49087911312927 1.502398412808566 1.0 16.57828166298708 -7.129430996469737 5.279772715183081 1.4538327274148366 0.9403547722334867 0.5502083843915204 0.2022464018365479 0.1624194979455977 6.29628219933773 0.0782403827129721 0.06035256921746184 7.422821269792329e-08 7.129430996469737 -0.5134779551813499 SLDLLAALPT(ph)PPHNQTEDVR ddPTM_A459_Selumetinib_30min_R1 1 SLDLLAALPTPPHNQTEDVR 20 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 SLDLLAALPT(1)PPHNQTEDVR 99.078 0.0011385 11839000.0 3026.7 2944.3 2340.1 1968.7 2952.8 2010.9 3257.7 3331.0 1813.8 2901.2 True False 3097.21622106701 2599.5799872320654 2022.3272732491946 1624.9035020759325 2685.719761359181 1990.6721717511139 3011.969066210684 3242.651059387111 3077.8861252894108 3273.597280081101 0.9461201107151087 0.794105005844721 0.6177691084833419 0.4963663404668019 0.8204184973212846 0.6080992869415497 0.9200792915297341 0.9905467233607846 0.9402152622796529 1.0 11.67666113617299 -7.39478073306122 5.229428728692877 0.9704867192056379 0.7087203213688321 0.5137685963040153 0.11928353947186243 0.20068833666197683 7.6878580997057835 0.05424190432840061 0.03587494897454106 4.0292040975358274e-08 7.39478073306122 -0.2617663978368058 SLDLLAALPT(ph)PPHNQTEDVR ddPTM_A459_Selumetinib_30min_R2 2 SLDLLAALPTPPHNQTEDVR 20 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 SLDLLAALPT(1)PPHNQTEDVR;SLDLLAALPT(1)PPHNQTEDVR 90.592 0.0022609 15557100.0 46946.0 35400.3 50165.0 55771.0 59827.0 44731.0 49693.0 50056.0 44791.0 49886.0 True False 44336.92925972805 38115.38918009482 46937.438515522255 48174.893589658765 52310.99739983397 50892.28922241068 52003.82296481148 50201.65467278308 53750.45156510594 48445.6615606061 0.9151888493515983 0.786765789799609 0.9688677376570234 0.9944108933137675 1.0797870379867203 1.0505025131867345 1.073446440601375 1.0362466535828023 1.1094997948962568 1.0 15.564079853750227 -5.631428641027996 1.9369107812741877 1.0583738818855501 0.8508019622904158 0.7592204970321186 0.04423193917636008 0.1408636845725259 1.0598622645602525 0.012217815513334129 0.028256592671018762 2.336529986167866e-06 5.631428641027996 -0.20757191959513432 SLDNNYS(ph)TPNER ddPTM_A459_Selumetinib_30min_R1 1 SLDNNYSTPNER 12 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;C9JZR2;O60716-19;O60716-11;O60716-13;O60716-21;O60716-9;O60716-17;O60716-10;O60716-18;O60716-27;O60716-29;O60716-25;O60716-26;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 SLDNNYS(0.5)T(0.5)PNER 144.51 0.00073684 20482000.0 5820.6 6064.2 7041.5 7607.2 7422.8 5387.2 6776.4 6454.0 3880.1 5411.9 True False 5956.208655083968 5354.200644829907 6085.3029761908465 6278.745324829603 6751.409050601783 5333.009659186238 6265.250692289058 6282.818954453446 6584.246308708481 6106.570081370094 0.9753771062507169 0.8767934492661414 0.9965173403570476 1.0281950818815264 1.1055975712452661 0.8733232548097939 1.0259852271904757 1.0288621715193365 1.0782233268386914 1.0 12.576146563884818 -5.439027187296489 6.006693914049062 1.0185131116311004 0.9268202931693899 0.26640892985437625 0.06140917626780853 0.30000459369827753 17.05845304685166 0.016203666832643376 0.0340640837271941 3.6389225537193766e-06 5.439027187296489 -0.09169281846171051 SLDNNYST(ph)PNER ddPTM_A459_Selumetinib_30min_R1 1 SLDNNYSTPNER 12 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;C9JZR2;O60716-19;O60716-11;O60716-13;O60716-21;O60716-9;O60716-17;O60716-10;O60716-18;O60716-27;O60716-29;O60716-25;O60716-26;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 SLDNNYST(1)PNER 212.1 9.8061e-06 19627000.0 4439.6 4642.9 5829.4 5369.3 5155.6 3594.3 4874.9 4356.8 2771.9 4047.5 True False 4543.034042042193 4099.307109574347 5037.799498602135 4431.652549243818 4689.276890295109 3558.1446053632853 4507.182368195492 4241.243511119113 4703.711848434071 4567.036050988645 0.9947445107333329 0.8975858880481036 1.1030785486161385 0.9703563755062716 1.026765901985819 0.7790927344646292 0.986894414205424 0.92866433804502 1.0299265860657787 1.0 12.157042462680797 -4.403409556353448 21.3729369067587 0.9663022644810982 11.174021494811944 0.0074103007182582115 0.0831706859538511 3749.3049424204714 672802.3980542888 0.019813195042822043 5749.5202510357085 3.949939499301728e-05 4.403409556353448 10.207719230330845 SLDNNYST(ph)PNER ddPTM_A459_Selumetinib_30min_R2 2 SLDNNYSTPNER 12 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;C9JZR2;O60716-19;O60716-11;O60716-13;O60716-21;O60716-9;O60716-17;O60716-10;O60716-18;O60716-27;O60716-29;O60716-25;O60716-26;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 SLDNNYS(0.001)T(0.999)PNER;SLDNNYS(0.004)T(0.996)PNER 206.74 2.34e-05 44236000.0 94831.0 89409.0 110617.0 102170.0 109185.0 82900.0 96566.0 92543.0 77733.0 86137.0 True False 89560.672658571 96266.38280475304 103500.02265068347 88254.2697469195 95468.20417371538 94318.72250872658 101056.51034189879 92812.28480868158 93281.77204149021 83650.00099919674 1.0706595527647516 1.1508234507454154 1.2372985225867164 1.0550420644677216 1.1412815664477054 1.12754000456775 1.208087377582568 1.1095311858941022 1.1151437050477258 1.0 16.352077937046026 -8.841711653045472 1.5866024752801502 1.0002295910197976 1.140998396319162 0.3830800051631015 0.05218414623335349 1.2998261730440346 5.002459470466239 0.04944559684365414 0.014186570964277948 1.4397541762709152e-09 8.841711653045472 0.1407688052993643 SLDQEIAR ddPTM_A459_Selumetinib_30min_R2 1 SLDQEIAR 8 0 P48681 P48681 NES Nestin 0 140.98 0.031952 88166000.0 78748.0 77117.0 98428.0 89883.0 84656.0 65205.0 64652.0 80674.0 55295.0 82610.0 False True 74371.50141322086 83031.62592976261 92095.2496403035 77640.78034317661 74020.75644575771 74186.39687794347 67658.4461055077 80908.74798370044 66355.54507138794 80224.83465344323 0.9270383882309298 1.0349865635553406 1.14796434343727 0.9677898456079184 0.9226663634211772 0.9247310661145676 0.8433603683669768 1.0085249578040463 0.8271197486168951 1.0 16.291761290608065 -5.992708307951343 24.989729223617466 0.9202854519646566 1.0400590726196524 0.33453263584364223 0.07294266342051141 192.03675567197567 658130.2813640528 0.02002369003867131 0.029631306830795127 1.0169314812696986e-06 5.992708307951343 0.11977362065499575 SLDQTS(ph)PCPLVLVR ddPTM_A459_Selumetinib_30min_R2 1 SLDQTSPCPLVLVR 14 0 Q6XZF7 Q6XZF7 DNMBP Dynamin-binding protein 1 SLDQT(0.069)S(0.931)PCPLVLVR 140.03 0.00056578 1305000.0 10490.0 10387.0 10027.0 12356.0 9785.4 9447.8 11046.0 9284.6 9311.6 9886.6 True False 9907.007794797151 11183.64950053093 9381.873736572148 10673.09148471111 8556.070569414067 10749.14869141069 11559.660887233755 9311.616648851726 11174.18018784222 9601.148169528291 1.0318565675550748 1.1648241755111242 0.9771616447236939 1.1116474088572976 0.8911507684642295 1.1195690871145885 1.2039873443388058 0.9698440732749581 1.1638379067314417 1.0 13.22899122793707 SLDS(ph)DESEDEEDDYQQKR ddPTM_A459_Selumetinib_30min_R2 1 SLDSDESEDEEDDYQQKR 18 1 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 S(0.046)LDS(0.632)DES(0.321)EDEEDDYQQKR 81.357 0.005389199999999999 6845700.0 14421.0 17089.0 23424.0 20003.0 18743.0 8595.9 11257.0 12133.0 8340.7 16980.0 True False 13619.53855183696 18399.671350204393 21916.925342122864 17278.55689290033 16388.33677545402 9779.907199188929 11780.472805322328 12168.305021273727 10009.073058629616 16489.743280661725 0.8259399991878111 1.1158252155315558 1.3291247152298509 1.0478366217601267 0.9938503284446745 0.593090324860198 0.7144121412210114 0.7379317442463798 0.6069878037681589 1.0 14.009281318009533 -6.613111466675566 4.726681122051718 0.7143126487791693 1.0919590845225413 0.5376542936172497 0.15468354095357428 0.15581180104279127 6.092812913874683 0.05209522117928799 0.05213301195983332 2.4371852064626104e-07 6.613111466675566 0.377646435743372 SLDS(ph)PTSSPGAGTR ddPTM_A459_Selumetinib_30min_R1 4 SLDSPTSSPGAGTR 14 0 Q9P107;K7EJC2 Q9P107 GMIP GEM-interacting protein 1 S(0.005)LDS(0.548)PT(0.253)S(0.174)S(0.021)PGAGTR;SLDS(0.572)PT(0.252)S(0.17)S(0.007)PGAGTR;S(0.048)LDS(0.528)PT(0.232)S(0.155)S(0.036)PGAGT(0.001)R;SLDS(0.684)PT(0.261)S(0.049)S(0.006)PGAGTR 144.51 0.00052922 35124200.0 5732.0 6601.8 7973.5 7300.7 7086.000000000001 5932.799999999999 6458.8 5793.5 3656.42 5430.999999999999 True False 5865.54444746956 5828.858186906446 6890.7424953003965 6025.76979611203 6445.072551134908 5873.121418551404 5971.607515990287 5639.837560059814 6204.6776856493025 6128.121752419848 0.9571520743943113 0.9511655320171747 1.1244460821261275 0.9832979890996125 1.0517207084846028 0.9583885007232843 0.9744596725142156 0.9203207422947786 1.012492560742486 1.0 12.58122924541507 -6.784972358821089 24.97104410662301 0.9682352897837252 1.0145698330140958 0.12730927096260747 0.05210280612626025 451.74178637971283 479343.0571950874 0.018437193842323292 0.016268729046157955 1.6406941937723734e-07 6.784972358821089 0.04633454323037056 SLDS(ph)PTSSPGAGTR ddPTM_A459_Selumetinib_30min_R2 1 SLDSPTSSPGAGTR 14 0 Q9P107;K7EJC2 Q9P107 GMIP GEM-interacting protein 1 SLDS(0.778)PT(0.115)S(0.081)S(0.026)PGAGTR 106.55 0.0084493 0.0 14501.0 16280.0 20703.0 22290.0 23849.0 13952.0 13969.0 16969.0 13346.0 17208.0 True False 13695.092472102338 17528.623651549387 19370.991519722058 19254.063547605278 20852.875407234857 15873.76135635408 14618.586179048381 17018.376980630826 16015.572918396643 16711.1603282466 0.8195177476068941 1.0489172090534638 1.1591649615723925 1.1521679625717223 1.2478412628228803 0.9498898367651302 0.8747798412500912 1.01838392106531 0.9583758759902378 1.0 14.028524288992195 SLDSDES(ph)EDEEDDYQQK ddPTM_A459_Selumetinib_30min_R2 1 SLDSDESEDEEDDYQQK 17 0 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 SLDS(0.019)DES(0.981)EDEEDDYQQK 226.65 2.3912e-51 0.0 17063.0 12096.0 15355.0 13429.0 16063.0 12313.0 11592.0 12079.0 10843.0 16108.0 True False 16114.706768600932 13023.724305229809 14367.07601725992 11599.94703368288 14045.022334958012 14009.00398371471 12131.05096911224 12114.147890213897 13011.902978733315 15642.920186389818 1.0301597512861822 0.8325634951817468 0.9184395142385275 0.7415461368763779 0.8978516905799939 0.8955491568577648 0.7754978497983329 0.7744172920318201 0.8318077969901279 1.0 13.933222236514887 SLDSEPSVPSAAKPPS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 SLDSEPSVPSAAKPPSPEK 19 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 SLDSEPSVPS(0.001)AAKPPS(0.999)PEK;SLDSEPSVPS(0.001)AAKPPS(0.999)PEK 100.07 0.00071791 172441000.0 8356.0 10841.3 8715.4 10174.900000000001 6678.0 8936.0 8319.8 8470.400000000001 5337.9 9104.3 True False 8550.678542054362 9571.995556016362 7531.896550265386 8398.044721528124 6073.976079096663 8846.111953238827 7692.230787690589 8245.737476263163 9058.026435209138 10272.925588391829 0.8323508691347316 0.9317691901547985 0.7331793154207461 0.8174929964466717 0.5912605933756706 0.8611093185795808 0.7487867717432544 0.8026669136570654 0.8817377637237538 1.0 13.32655947949224 -8.547166880824678 2.054041783229337 0.9993030960044763 0.7869632298525664 0.37597807208023226 0.0850010334081575 0.3774789410247789 3.6622930877854265 0.08222693488186344 0.02288378028297004 2.83682874682806e-09 8.547166880824678 -0.21233986615190992 SLDSEPSVPSAAKPPS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 4 SLDSEPSVPSAAKPPSPEK 19 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 SLDSEPSVPSAAKPPS(1)PEK;SLDSEPSVPS(0.002)AAKPPS(0.998)PEK;SLDSEPSVPSAAKPPS(1)PEK;SLDSEPSVPSAAKPPS(1)PEK 92.096 0.0012795 355182000.0 249903.0 220136.0 195527.0 194787.0 184116.0 139804.0 219841.0 181772.0 117340.0 171234.0 True False 236014.3917009718 237019.72335119647 182947.00569370098 168256.6745736828 160985.70206207625 159060.73198564543 230064.0421066771 182300.9264260253 140811.27875353355 166290.02950063752 1.4192937027536396 1.425339354758415 1.100168219604529 1.0118265964529025 0.9681019514249293 0.9565259713002554 1.3835107420303578 1.096282964008533 0.8467812482587461 1.0 17.343342143836438 -5.295897766085869 4.148053458151127 1.0504190009875922 1.4287579462480373 0.5672992477582581 0.13217411670036247 0.15520691487767552 6.097561169511232 0.03702210323718586 0.08935819448677251 5.059437483012509e-06 5.295897766085869 0.3783389452604451 SLDSESIS(ph)PGDFHR ddPTM_A459_Selumetinib_30min_R2 1 SLDSESISPGDFHR 14 0 Q52LW3;F8VWZ8 Q52LW3 ARHGAP29 Rho GTPase-activating protein 29 1 SLDSES(0.018)IS(0.982)PGDFHR 80.545 0.022327 2955300.0 21694.0 20071.0 25352.0 24916.0 27339.0 18915.0 21307.0 21490.0 19889.0 22156.0 True False 20488.334327962773 21610.381161563135 23720.87992117053 21522.3978175026 23904.430406239007 21520.36955672574 22297.817719019535 21552.532342138984 23867.355745091492 21516.29871179866 0.9522239211490314 1.0043726131071458 1.102460987314838 1.0002834644464476 1.1109917521795138 1.0001891981972182 1.0363221861570606 1.001684008519572 1.1092686555798563 1.0 14.393142302732453 -4.956169015281069 4.5013038032335055 1.0446699100422474 0.9581904480772544 0.2965746964463144 0.04460261093725447 0.23647380127826542 10.497934364763037 0.01045873422718943 0.04612897285275251 1.1061932007035472e-05 4.956169015281069 -0.08647946196499301 SLEDLQDEYDFK ddPTM_A459_Selumetinib_30min_R2 1 SLEDLQDEYDFK 12 0 A0A669KB68;A0A669KB56;A0A669KBA4;A0A669KB53;P42224;A0A669KB75;A0A669KB52;J3KPM9;A0A669KBI6;P42224-2;E7EPD2;D2KFR9;A0A669KB17 A0A669KB68 STAT1 Signal transducer and activator of transcription 1-alpha/beta;Signal transducer and activator of transcription 0 125.82 0.039098 1233900.0 11508.0 11187.0 13981.0 13427.0 12436.0 9388.4 10607.0 9796.9 9089.4 10814.0 False True 10868.431430174036 12045.006928125484 13081.477681361845 11598.219437133066 10873.678500749405 10681.566880590206 11100.246517371766 9825.407357035898 10907.533979055477 10501.771721853704 1.0349140809790534 1.1469499858828942 1.2456448328751892 1.1044059749458945 1.0354137176798255 1.0171204596232422 1.0569879836820928 0.9355952135761699 1.0386375049799836 1.0 13.358345120651132 -6.232905146966798 3.0392352851225173 1.0107013093261437 1.1463107114127062 0.524798182367413 0.056251060715299304 0.20679071554524805 3.871256234673038 0.01832997046744106 0.023360194985241133 5.849178204465666e-07 6.232905146966798 0.13560940208656258 SLENETLNKEEDCHS(ph)PTSKPPKPDQPLK ddPTM_A459_Selumetinib_30min_R1 3 SLENETLNKEEDCHSPTSKPPKPDQPLK 28 3 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SLENETLNKEEDCHS(0.46)PT(0.46)S(0.079)KPPKPDQPLK;SLENETLNKEEDCHS(0.854)PT(0.073)S(0.073)KPPKPDQPLK;SLENETLNKEEDCHS(0.711)PT(0.145)S(0.145)KPPKPDQPLK 95.153 1.0056e-06 82504000.0 4389.7 4882.5 5637.2 6467.700000000001 4542.3 4131.8 4867.799999999999 4443.1 2276.48 3864.7999999999997 True False 4491.97146913069 4310.854630187331 4871.699202923108 5338.237608765431 4131.449767008199 4090.237843374236 4500.617926911737 4325.254554777207 3863.0202924792347 4360.884726339942 1.030059667021001 0.9885275352841989 1.117135514611937 1.2241180273631709 0.9473879788782433 0.9379376204716015 1.032042397206191 0.9918296002305387 0.8858340760869959 1.0 12.090405140035584 SLENETLNKEEDCHS(ph)PTSKPPKPDQPLK ddPTM_A459_Selumetinib_30min_R2 1 SLENETLNKEEDCHSPTSKPPKPDQPLK 28 3 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.001)LENET(0.009)LNKEEDCHS(0.824)PT(0.083)S(0.083)KPPKPDQPLK 45.639 0.021668 48425000.0 76877.0 70077.0 69021.0 77937.0 84028.0 65951.0 68479.0 80536.0 53596.0 80386.0 True False 72604.48410301442 75451.68056693033 64580.26400438271 67321.84615117591 73471.65142014898 75035.15160642978 71663.40918856417 80770.34642654755 64316.69759736149 78065.04731208921 0.930051112538951 0.9665232157650383 0.8272622156520715 0.8623814174099705 0.9411593786195157 0.9611875505109669 0.9179961026868719 1.034654422274838 0.8238859747338084 1.0 16.252389123093863 -6.409305181604617 7.348802776198338 0.9482052108860047 0.8967423887342396 0.13447517926157648 0.06219593043671367 0.5582859213004362 32.473551915470004 0.019040477015790324 0.021573606873221973 3.896680681171081e-07 6.409305181604617 -0.05146282215176512 SLENPT(ph)PPFTPK ddPTM_A459_Selumetinib_30min_R1 2 SLENPTPPFTPK 12 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 SLENPT(0.97)PPFT(0.03)PK;SLENPT(0.999)PPFT(0.001)PK 141.85 0.0022391 18536600.0 8621.9 9170.0 10518.8 10799.599999999999 9038.4 8927.0 8491.4 7763.4 4426.6 7782.8 True False 8822.773494703026 8096.372136982661 9090.404735632512 8913.652593599452 8220.878315859123 8837.202485067479 7850.886861534644 7557.489412922815 7511.616893927718 8781.79819089177 1.004665935486169 0.9219492364764185 1.035141612006163 1.0150145106778288 0.936126990982961 1.0063089919594341 0.8939953630086102 0.8605856395972783 0.8553620489387415 1.0 13.10030066581921 -7.271513564374733 23.13973749347703 0.8908678723048213 0.9848115533061365 0.3987716284979237 0.04972002423855213 234.14053870172148 537800.6926570932 0.019945728788487736 0.01365144636950538 5.351634386825794e-08 7.271513564374733 0.09394368100131512 SLENPT(ph)PPFTPK ddPTM_A459_Selumetinib_30min_R2 1 SLENPTPPFTPK 12 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 SLENPT(0.996)PPFT(0.004)PK 114.64 0.012749 12707000.0 174060.0 152780.0 171790.0 182670.0 181550.0 170410.0 155430.0 163120.0 116840.0 164460.0 True False 164386.4420173872 164497.73473487215 160737.21843080944 157790.03087667402 158742.06592240726 193882.43067203995 162657.80297870204 163594.65219403038 140211.26478236637 159711.6124816032 1.0292704422874854 1.0299672777633515 1.0064216116365639 0.9879684290010502 0.9939293922080487 1.2139532477287636 1.0184469397767693 1.0243128201643725 0.877902756122489 1.0 17.285109688003423 -8.110492599274847 6.510571043002584 0.9397637733986919 1.0398944678651805 0.2637339783559075 0.0666166320424672 0.3330952432248932 16.952238891816187 0.047079201877159325 0.017498231195940774 7.753671561231988e-09 8.110492599274847 0.10013069446648859 SLENYHFVDEHGK ddPTM_A459_Selumetinib_30min_R2 1 SLENYHFVDEHGK 13 0 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 0 100.02 0.0063551 2032700.0 17254.0 12913.0 21887.0 20229.0 21170.0 18779.0 13946.0 19042.0 17495.0 15112.0 False True 16295.091753234525 13903.385578160765 20478.814248763792 17473.775303028593 18510.43533779874 21365.6367912108 14594.516633474746 19097.409067427197 20994.48885114261 14675.677294308598 1.1103468294137235 0.9473760767111351 1.3954254947201463 1.190662274224654 1.2613002430202866 1.4558535434338453 0.9944697161700792 1.3012966069261689 1.4305635392571983 1.0 13.841139465957502 -5.253250406095312 24.955094598854405 1.2604391666861945 1.0288614463028742 0.24831543721707117 0.15612089775342186 770.2262626697074 2347174.791803225 0.03809229521602805 0.09718425534581944 5.581482840551022e-06 5.253250406095312 -0.23157772038332025 SLEPAENVHGAGGGAFPAS(ph)QTPSKPASADGHR ddPTM_A459_Selumetinib_30min_R1 1 SLEPAENVHGAGGGAFPASQTPSKPASADGHR 32 1 P12931;P12931-2 P12931 SRC Proto-oncogene tyrosine-protein kinase Src 1 S(0.36)LEPAENVHGAGGGAFPAS(0.447)QT(0.175)PS(0.013)KPAS(0.005)ADGHR 88.10799999999998 1.2617e-07 17898000.0 924.21 701.77 554.13 447.85 772.09 742.68 868.18 709.98 92.731 501.19 True False 945.7422948003906 619.6064421559781 478.8821896182111 369.64140468568394 702.2545958235609 735.209313499487 802.6924836242723 691.1490240599405 157.35773419572843 565.5226185040145 1.672333278732824 1.0956351202981631 0.846795820271531 0.6536279763018178 1.2417798560935467 1.3000528881485718 1.4193817494827117 1.2221421415260938 0.2782518842694377 1.0 9.143440916820948 -8.238424506664636 24.80556834218819 0.6391258726423426 1.1637506944412956 0.3237308634351006 0.3127084058640353 775.7892574753796 836153.2558967968 0.2203403021295877 0.08315893793502012 5.775312561481999e-09 8.238424506664636 0.5246248217989531 SLEPEES(ph)PGKR ddPTM_A459_Selumetinib_30min_R1 1 SLEPEESPGKR 11 1 Q5JWZ0;Q5JXL1;Q9BVI0 Q5JWZ0 PHF20 PHD finger protein 20 1 SLEPEES(1)PGKR 124.38 0.0064476 8036300.0 2229.2 2533.0 2550.9 2722.8 2253.8 2069.7 1976.9 2294.7 1354.4 2037.3 True False 2281.1360227318783 2236.435182440248 2204.501791090711 2247.314093286101 2049.94418794071 2048.8806971372424 1827.7808413886783 2233.8371017639165 2298.317878537864 2298.8072999824994 0.9923128496891602 0.9728676181153912 0.9589763313817098 0.9776000334187253 0.8917425083678462 0.8912798811596084 0.7950996333631761 0.9717374317459851 0.999787097663802 1.0 11.166669820308682 -6.248425017533438 23.79010609421323 0.9153528304881781 0.9740796125774654 0.1418409772881125 0.058004931960957885 752.4801027141797 1375521.9610607035 0.0180989868308675 0.02319692138252846 5.643843758769933e-07 6.248425017533438 0.05872678208928739 SLEPEES(ph)PGKR ddPTM_A459_Selumetinib_30min_R2 2 SLEPEESPGKR 11 1 Q5JWZ0;Q5JXL1;Q9BVI0 Q5JWZ0 PHF20 PHD finger protein 20 1 SLEPEES(1)PGKR;SLEPEES(1)PGKR 76.868 0.025957 29645000.0 105769.0 111195.0 120090.0 108342.0 121016.0 97948.0 101143.0 104148.0 84482.0 111858.0 True False 99890.78240685418 119723.29895172223 112363.54014410579 93585.63269962562 105812.88818323346 111439.4479165833 105846.34991105234 104451.05343737034 101380.76062430568 108628.36889801272 0.91956441415997 1.1021365796638827 1.0343848599034005 0.8615211076904765 0.9740815337343175 1.0258779455780083 0.9743895723080191 0.9615448938153135 0.9332807042282706 1.0 16.72904139455671 SLEPEPQQSLEDGS(ph)PAKGEPSQAWR ddPTM_A459_Selumetinib_30min_R2 2 SLEPEPQQSLEDGSPAKGEPSQAWR 25 1 Q8IV36-3;Q8IV36-2;Q8IV36 Q8IV36-3 HID1 Protein HID1 1 S(0.001)LEPEPQQS(0.301)LEDGS(0.698)PAKGEPSQAWR;SLEPEPQQS(0.006)LEDGS(0.994)PAKGEPSQAWR 75.436 0.0001682 15515500.0 45452.0 38124.0 41389.0 48388.0 43728.0 27422.0 32509.0 32868.0 21764.0 37180.0 True False 42925.959798772165 41047.98821201897 38726.07680093592 41797.47092604416 38234.49770672004 31199.13158786851 34020.73291536143 32963.640438409675 26117.408136968734 36106.51679475871 1.1888701433809694 1.1368581590229045 1.0725508921579905 1.1576157058747787 1.058936200466455 0.8640858869110696 0.942232481431162 0.9129554264618164 0.7233433312171499 1.0 15.139971629375976 -6.632506079648978 3.529503626553561 0.8858774807632146 1.1325863762471229 0.731617438827646 0.0720782668534038 0.12458058364243203 3.0157325998261673 0.024604578980831886 0.024535478778323436 2.3307404872300244e-07 6.632506079648978 0.24670889548390829 SLEPS(ph)PSPGPQEEDGEVALVLLGR ddPTM_A459_Selumetinib_30min_R1 1 SLEPSPSPGPQEEDGEVALVLLGR 24 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 S(0.041)LEPS(0.479)PS(0.479)PGPQEEDGEVALVLLGR 81.92200000000003 0.0012375 0.0 420.2 357.23 378.71 436.83 436.34 323.4 399.73 576.39 290.51 244.25 True False 429.98984243313134 315.4053455282785 327.2832621051247 360.5458408146644 396.87312404208393 320.1468896237062 369.57804427553083 561.1022648214163 492.9742519890979 275.6018666964737 1.5601847969581732 1.1444238361260493 1.1875219352761819 1.3082126225644959 1.440023352523838 1.1616281611629682 1.3409852723623064 2.035916053643317 1.7887188425034188 1.0 8.106441849459255 -7.558595441875192 23.505848850841765 1.6850819171107818 1.2911991021372722 0.18962911576005237 0.27331930422385103 111.96172143965673 73682.10010779976 0.12163517351620586 0.07022661322007931 2.763150614064862e-08 7.558595441875192 -0.39388281497350963 SLEQYDQVLDGAHGAS(ph)LTDLANLSEGVSLAER ddPTM_A459_Selumetinib_30min_R1 1 SLEQYDQVLDGAHGASLTDLANLSEGVSLAER 32 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2;M0R3I1 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 SLEQYDQVLDGAHGAS(0.907)LT(0.093)DLANLSEGVSLAER 113.75 7.3293e-13 7228600.0 940.6 748.2 1074.1 1116.2 939.08 1003.2 984.42 871.18 451.43 820.27 True False 962.5141499110028 660.6003961712564 928.2431196089736 921.2766236689976 854.14037980804 993.1087188327205 910.1644068389115 848.0734764085456 766.0437388573154 925.5596446064125 1.0399266600698704 0.7137307682123197 1.0028992999189181 0.9953725068261416 0.9228366694523042 1.0729818706119505 0.9833665632925821 0.9162818207887431 0.8276546447561139 1.0 9.85418215253968 -4.46061686379156 24.113642004781283 0.9397873078151133 4.216550277872849 0.09044622157292692 0.09739274847054313 2439.146997638881 963965.2753857098 0.023645541016383626 8787.87692137111 3.462447014919099e-05 4.46061686379156 3.2767629700577356 SLESS(ph)KEIPEQR ddPTM_A459_Selumetinib_30min_R1 1 SLESSKEIPEQR 12 1 Q9BXY4;Q9BXY4-2 Q9BXY4 RSPO3 R-spondin-3 1 SLES(0.244)S(0.756)KEIPEQR 85.287 0.017304 21351000.0 1217.5 3710.7 1856.2 2719.2 1987.2 2834.9 3143.9 1505.4 2310.5 2360.2 True False 1245.865381157395 3276.2495189423703 1604.138235376759 2244.342765705732 1807.458110868655 2806.3834798832545 2906.7530918315883 1465.4719017716482 3920.749747756744 2663.1546602948497 0.46781563223949585 1.2302137640701807 0.6023451282394383 0.8427384256599092 0.6786906287555013 1.0537816378912621 1.091469877873998 0.550276678865282 1.4722200727623758 1.0 11.378920498851361 -6.771379162445064 24.97513430894226 1.0090619903882456 0.7855948875215167 0.18386140987140875 0.2794309298802755 415.5609300398321 1044150.0756026083 0.09236857750996408 0.08241459421437584 1.6928591979463024e-07 6.771379162445064 -0.22346710286672888 SLETENRR ddPTM_A459_Selumetinib_30min_R2 1 SLETENRR 8 1 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 0 92.47 0.034391000000000005 5411500.0 12936.0 11694.0 9557.2 10680.0 9623.4 9999.9 17838.0 30918.0 15662.0 21622.0 False True 12217.06890691096 12590.892197863555 8942.300157092584 9225.36557597238 8414.422457712439 11377.295454945892 18667.50234532643 31007.966261249574 18794.837632843406 20997.716679297282 0.5818284479929378 0.5996314928030988 0.4258701216741939 0.4393508930934447 0.4007303549346699 0.5418348875124763 0.8890253464431049 1.476730386205368 0.8950895909255787 1.0 14.3579448353193 -7.3875418238492445 3.2947352084227344 1.1455549932732412 0.4902698622229684 0.7694810851147015 0.1550248527126541 0.10878287501665287 2.2050040417715997 0.06896027131604142 0.04361818709526979 4.096926532936443e-08 7.3875418238492445 -0.6552851310502728 SLFS(ph)PQNTLAAPTGHPPTSGVEK ddPTM_A459_Selumetinib_30min_R1 2 SLFSPQNTLAAPTGHPPTSGVEK 23 0 Q5VT52-2;Q5VT52-3;Q5VT52 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.024)LFS(0.946)PQNT(0.03)LAAPTGHPPTSGVEK;S(0.103)LFS(0.699)PQNT(0.198)LAAPT(0.001)GHPPTSGVEK 100.57 3.079e-05 60853000.0 6328.4 6421.2 8190.0 8225.9 8152.900000000001 6887.099999999999 6914.6 6923.299999999999 3611.2 5457.6 True False 6475.839407077171 5669.402918865105 7077.842984449766 6789.400984266984 7415.471634511404 6817.822026986478 6393.026155023605 6739.671593952207 6127.942648387429 6158.136121525785 1.0515908189234164 0.9206361806533779 1.1493482516096296 1.1025090790920666 1.204174686654067 1.1071242811854642 1.038143040176842 1.0944336826842238 0.995096978608054 1.0 12.58827804221691 -10.640073058625353 12.185692257670901 1.0000060653107097 1.0766335353181509 0.07831491421974357 0.07520790549192297 0.0 0.0 0.07661894181718178 0.018582822943252617 2.2904823069442894e-11 10.640073058625353 0.07662747000744119 SLFS(ph)PQNTLAAPTGHPPTSGVEK ddPTM_A459_Selumetinib_30min_R2 2 SLFSPQNTLAAPTGHPPTSGVEK 23 0 Q5VT52-2;Q5VT52-3;Q5VT52 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 1 S(0.085)LFS(0.705)PQNT(0.209)LAAPT(0.001)GHPPTSGVEK;S(0.213)LFS(0.776)PQNT(0.011)LAAPTGHPPTSGVEK 112.9 8.515900000000001e-06 41526000.0 75574.0 70097.0 93711.0 102847.0 110863.0 75526.0 74317.0 81477.0 73532.0 93962.0 True False 71373.89962669212 75473.21450262041 87681.73628482228 88839.06117902933 96935.39881220496 85929.0209432338 77772.88775634179 81714.08458075649 88240.45465574268 91249.07291740524 0.7821876688138708 0.8271121238780753 0.9609055027242638 0.9735886441218164 1.0623165333410756 0.9416974682144231 0.8523142785980794 0.8955059154926494 0.9670285059839914 1.0 16.477522280848575 -5.169223792446939 3.627901254951741 0.9533386341282393 0.7912069267545442 0.5670631625619114 0.05357204211429501 0.19588393802302037 4.748551796498948 0.015740788883680513 0.04933559825770125 6.772924081144047e-06 5.169223792446939 -0.1621317073736951 SLGEISALT(ph)SK ddPTM_A459_Selumetinib_30min_R2 1 SLGEISALTSK 11 0 P18206;P18206-2 P18206 VCL Vinculin 1 SLGEISALT(0.94)S(0.06)K 101.38 0.025075 0.0 19214.0 21765.0 32230.0 19781.0 25742.0 16268.0 9777.7 10744.0 7348.0 26914.0 True False 18146.16279973618 23434.30551449461 30156.3568893707 17086.793675871682 22508.059823600128 18508.769333799315 10232.382424144993 10775.263261235055 8817.805320274134 26136.922889030015 0.694273112285622 0.8965977216977701 1.1537837494262835 0.6537415956888796 0.8611595144219152 0.708146456734112 0.3914914723354695 0.4122621207930167 0.33736968034500625 1.0 14.673801681583765 -7.024269623313367 3.39947000654056 0.4876514265579155 0.8588901765833955 0.3153916376845717 0.21434068906240103 0.2513568114652474 6.029569959260527 0.0822116329557339 0.06587355204566682 9.456498906769418e-08 7.024269623313367 0.37123875002548 SLGEKS(ph)PAASGAR ddPTM_A459_Selumetinib_30min_R1 1 SLGEKSPAASGAR 13 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 SLGEKS(0.956)PAAS(0.043)GAR 124.5 0.010671 5557000.0 1081.2 1135.7 1387.9 1654.1 1398.8 1167.9 1435.3 1285.0 889.34 1086.9 True False 1106.3898563510265 1002.7317160273936 1199.4308031889914 1365.2424863025337 1272.2787869781985 1156.151986368356 1327.0341654333401 1250.9176257317442 1509.1450251763604 1226.414202302546 0.9021339236563158 0.8176126093001883 0.9779981354888957 1.1131985292891609 1.0373973039365847 0.9427092284137972 1.0820440296124132 1.019979729020745 1.2305345309463946 1.0 10.26023059377795 -5.473507027963505 4.339143195262465 1.0564985177698443 0.8630081284649657 0.5326431693099208 0.07475429206339455 0.16149632165264918 6.420617536623518 0.0198871585900497 0.04180713394645533 3.361189297638398e-06 5.473507027963505 -0.1934903893048786 SLGEKS(ph)PAASGAR ddPTM_A459_Selumetinib_30min_R2 1 SLGEKSPAASGAR 13 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 SLGEKS(1)PAASGAR 157.07 0.0017327999999999998 4752900.0 13650.0 12241.0 11575.0 16072.0 12387.0 11681.0 13810.0 13115.0 8996.8 14846.0 True False 12891.387645279427 13179.845338981326 10830.277101907108 13882.96587425356 10830.834318814967 13289.951720439505 14452.19236399586 13153.162478694869 10796.41139159531 14417.3574054596 0.8941574577597476 0.914165125294761 0.75119710202966 0.9629341552562417 0.7512357510616696 0.9218021962476171 1.002416181936578 0.9123143797291172 0.7488481479627396 1.0 13.815519133073067 SLGEKSPAAS(ph)GAR ddPTM_A459_Selumetinib_30min_R1 1 SLGEKSPAASGAR 13 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 SLGEKS(0.301)PAAS(0.699)GAR 132.51 0.0067226 5546600.0 1255.6 1503.4 1484.2 1610.2 1626.8 1202.5 1369.0 1297.7 756.64 994.47 True False 1284.853037027699 1327.3812290883022 1282.653792127026 1329.008797197474 1479.656227234868 1190.4039417826418 1265.7352278117773 1263.28078047633 1283.9628172008915 1122.119911458104 1.1450229373063494 1.182922801328316 1.1430630354471842 1.1843732417781756 1.3186257655050202 1.0608527035544786 1.1279857124779622 1.1257983817743673 1.1442295997871437 1.0 10.132011137455791 -9.246712862086833 0.4075437520571218 0.9806437381117721 1.1819996769939405 0.4092537808253579 0.06045775387945685 3.2458100835458947 0.873468610830492 0.18373757897161438 0.04395114030479355 5.666137872991912e-10 9.246712862086833 0.2013559388821684 SLGGESS(ph)GGTTPVGSFHTEAAR ddPTM_A459_Selumetinib_30min_R1 2 SLGGESSGGTTPVGSFHTEAAR 22 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 SLGGES(0.093)S(0.907)GGTTPVGSFHTEAAR;SLGGES(0.056)S(0.943)GGT(0.001)TPVGSFHTEAAR 251.0 1.5208999999999998e-44 13943900.0 1650.08 1833.31 1515.94 1681.9299999999998 2560.3 1406.68 1998.21 1539.1399999999999 672.21 998.56 True False 1688.52365350324 1618.6652129173042 1310.083674462367 1388.212499236335 2328.721317057678 1392.5300763632501 1847.483410931899 1498.3170073686815 1140.6912737241123 1126.7349027980779 1.4985988712252045 1.4365980932139324 1.162725740730113 1.232066651870743 2.066787237419065 1.2358985888385188 1.6396788688660926 1.329786628290146 1.0123865612855125 1.0 10.13793240407035 -8.174138777056942 3.4506399099002 0.996818436644872 1.4609310213665814 0.3561240269815943 0.244027355102903 0.27835289428177884 5.970609240690553 0.20092482653106714 0.06434262892734871 6.6967058467799886e-09 8.174138777056942 0.46411258472170935 SLGGESS(ph)GGTTPVGSFHTEAAR ddPTM_A459_Selumetinib_30min_R2 2 SLGGESSGGTTPVGSFHTEAAR 22 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 S(0.017)LGGES(0.262)S(0.721)GGTTPVGSFHTEAAR;S(0.018)LGGES(0.263)S(0.718)GGTTPVGSFHTEAAR 146.65 2.7753e-07 31071000.0 28024.0 26092.0 47544.0 53623.0 72656.0 44175.0 28488.0 30155.0 38741.0 58622.0 True False 26466.538268960474 28093.172500996705 44485.070801993206 46319.45489516543 63528.30372711875 50259.70526927617 29812.748447901067 30242.746057571017 46490.28251398203 56929.430541752175 0.4649008081953297 0.4934736257442995 0.7814072682383104 0.813629338189052 1.1159132125961975 0.8828422274910266 0.5236790209246223 0.5312321899196044 0.816630028995037 1.0 15.796887048245678 -5.256465658918973 4.685621453637344 0.7964221027809343 0.47204836256100513 0.3679961596721092 0.17218391839828068 0.22502669915466914 14.17067988937993 0.05030510710840064 0.12746285068166088 5.540313512723567e-06 5.256465658918973 -0.32437374021992915 SLGGIS(ph)PSEDR ddPTM_A459_Selumetinib_30min_R1 1 SLGGISPSEDR 11 0 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 SLGGIS(0.679)PS(0.321)EDR 103.97 0.012757 4360700.0 2383.5 3144.4 1822.3 1778.6 2287.2 1976.1 2077.3 1884.8 1162.6 2214.5 True False 2439.0309125163453 2776.2521862081 1574.8416691773891 1468.000898456979 2080.323163837957 1956.2222281552424 1920.607588556175 1834.8089813067636 1972.8472870556118 2498.7526460566655 0.976099381571614 1.1110552261302704 0.6302511261619593 0.5874934843085259 0.8325446566793873 0.7828795023958847 0.7686265351583025 0.7342899603137247 0.789532845585578 1.0 11.286992379376185 -5.254754111984753 24.992007359461688 0.7529531586173999 1.0435773243732427 0.5010432770201787 0.11033305999952224 392.5858313698944 1467621.5840169638 0.02771560919597273 0.06984153739480947 5.562190871910786e-06 5.254754111984753 0.2906241657558428 SLGGIS(ph)PSEDRR ddPTM_A459_Selumetinib_30min_R1 1 SLGGISPSEDRR 12 1 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 SLGGIS(0.673)PS(0.327)EDRR 99.834 0.0071885 9165200.0 1768.0 2356.1 2489.5 2644.7 2489.1 2119.1 2359.2 2230.5 1126.7 1754.2 True False 1809.1909600708614 2080.2467166788274 2151.439573844653 2182.852792167531 2263.961344486298 2097.783777988854 2181.243644597184 2171.3398943149073 1911.9276090878698 1979.3686573549794 0.9140242538186264 1.0509647654311405 1.0869322224792681 1.1028025446681904 1.1437795258977266 1.0598246921784202 1.1019895846547196 1.0969860951604933 0.9659280003164086 1.0 10.950824623982971 -4.760778287578999 3.271515851010625 1.077627583705629 0.8867924974759595 0.45826450507781746 0.04989713449035372 0.30090319934774606 4.8216397973562595 0.0124069114107775 0.15137746393597912 1.73468935097979e-05 4.760778287578999 -0.1908350862296696 SLGGISPS(ph)EDR ddPTM_A459_Selumetinib_30min_R2 3 SLGGISPSEDR 11 0 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 SLGGIS(0.227)PS(0.773)EDR;SLGGIS(0.254)PS(0.746)EDR;SLGGIS(0.233)PS(0.767)EDR 145.14 0.00070712 13403700.0 61294.0 53019.0 75100.0 76796.0 79922.0 62563.0 63091.0 66037.0 61054.0 61208.0 True False 57887.52485932283 57085.386817045284 70268.1477626974 66336.25231951059 69881.48384825463 71180.4853596317 66024.85651244479 66229.15673698616 73266.5059912925 59440.76600251729 0.9738690927514515 0.9603743467005076 1.1821541424907205 1.1160060137297234 1.175649113359259 1.19750282754797 1.110767255416067 1.114204294308411 1.2325969350426895 1.0 15.859165087298642 -5.255776931980517 24.981691821561004 1.146456117226525 0.9671216961403458 0.5661984282020246 0.06077345059089198 290.06214162108455 1279692.3883542232 0.014522806172643232 0.03625898002798378 5.549106602531087e-06 5.255776931980517 -0.17933442108617925 SLGGQQGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SLGGQQGSPK 10 0 A0A0C4DGT3;A0A3B3IU98;A0A2R8Y7T6;A0A3B3IRZ4;Q6DN90;Q6DN90-3;Q6DN90-2;A0A2R8Y695 A0A0C4DGT3;A0A2R8Y7T6 IQSEC1 IQ motif and SEC7 domain-containing protein 1 1 SLGGQQGS(1)PK;SLGGQQGS(1)PK 92.295 0.026826 66567000.0 180193.0 159751.0 148605.0 133061.0 132661.0 99812.0 158465.0 159691.0 89722.0 163715.0 True False 170178.59442973137 172003.38801957428 139043.91608889043 114937.86225697173 115994.93917561244 113560.19699687588 165833.93649244055 160155.67437173193 107668.90704213886 158988.1225673459 1.0703855840403755 1.0818631306669795 0.8745553683105648 0.722933640582397 0.7295824197589228 0.7142684318998284 1.0430586500082408 1.0073436416855068 0.6772135257873197 1.0 17.27855946539777 -5.301395572473369 4.643071795131487 0.8383502864467541 1.0785185323725746 0.3420074834354302 0.12790880423492604 0.21947914010005726 11.303482031143567 0.03575257268897744 0.08254609175742847 4.995792912393891e-06 5.301395572473369 0.24016824592582042 SLGLQMPVVVQS(ph)MY(ph)IFK ddPTM_A459_Selumetinib_30min_R2 1 SLGLQMPVVVQSMYIFK 17 0 G5E9M0;H7C2Q0;X6RJK6;Q5SRE7;Q5SRE7-3 G5E9M0 PHYHD1 Phytanoyl-CoA dioxygenase domain-containing protein 1 2 S(0.002)LGLQMPVVVQS(0.998)MY(1)IFK 49.081 0.046517 0.0 18411.0 17314.0 31154.0 28386.0 34930.0 24267.0 18775.0 27307.0 24561.0 29551.0 True False 17387.790325072496 18641.92812671536 29149.58555791051 24519.777831418727 30541.781121837976 27609.558976106964 19648.074701956724 27386.458849082803 29473.886291678413 28697.78584728122 0.6058930963386426 0.6495946490757393 1.0157433647680556 0.8544135760822709 1.0642556636379477 0.962079761938242 0.6846547258564253 0.9543056385890952 1.0270439137195917 1.0 14.80865181086252 -5.222752700056403 8.208247460962577 0.9359262482127968 0.6259401325022619 0.6002810686379418 0.1034353863937456 0.22906968629562852 44.303389322289 0.027103061996100377 0.07132568197468737 5.987524451101677e-06 5.222752700056403 -0.3099861157105349 SLGLSLS(ph)GGDQEDAGR ddPTM_A459_Selumetinib_30min_R1 4 SLGLSLSGGDQEDAGR 16 0 H0YE82;H7C1L7;H0YEB7;C9JEV6;H7C3G9;Q9UJ70;Q9UJ70-2 H0YE82 NAGK N-acetyl-D-glucosamine kinase 1 SLGLS(0.002)LS(0.998)GGDQEDAGR;SLGLS(0.002)LS(0.998)GGDQEDAGR;SLGLS(0.002)LS(0.998)GGDQEDAGR;SLGLS(0.007)LS(0.993)GGDQEDAGR 289.87 1.3528999999999999e-74 57346400.0 4732.62 4883.5 5843.0 5976.6 5535.1 4525.48 4651.4 4551.79 2604.99 4033.0599999999995 True False 4842.880837924523 4311.737549722442 5049.552693301587 4932.899004676699 5034.451182301279 4479.957780007081 4300.541153136373 4431.061742902333 4420.477769058139 4550.742536331135 1.0641957437189828 0.9474800025049579 1.109610718028579 1.0839767280382475 1.106292246179261 0.9844454491197998 0.9450196575180285 0.9737008208059844 0.9713750522616871 1.0 12.15188625109004 -6.887625592492386 6.785333018796269 0.9696540505991061 1.0594960078928297 0.49559435249273165 0.044100141143874505 0.19913566063072327 11.126370120936452 0.01641779613667165 0.014481950699268059 1.295312055422264e-07 6.887625592492386 0.08984195729372357 SLGLSLS(ph)GGDQEDAGR ddPTM_A459_Selumetinib_30min_R2 4 SLGLSLSGGDQEDAGR 16 0 H0YE82;H7C1L7;H0YEB7;C9JEV6;H7C3G9;Q9UJ70;Q9UJ70-2 H0YE82 NAGK N-acetyl-D-glucosamine kinase 1 SLGLS(0.001)LS(0.999)GGDQEDAGR;SLGLS(0.003)LS(0.997)GGDQEDAGR;SLGLSLS(1)GGDQEDAGR;SLGLS(0.048)LS(0.952)GGDQEDAGR 218.34 2.3768e-39 25537500.0 127452.0 128274.0 141010.0 154194.0 159978.0 105311.0 113432.0 123083.0 97086.0 119423.0 True False 120368.72807078027 138112.2033340818 131937.5701200794 133192.51120051355 139880.13341853392 119816.63433192397 118706.81276124401 123441.1511525123 116505.91280949008 115974.9476917826 1.0378855991440037 1.190879634635677 1.1376385395811466 1.1484593341183365 1.206123703459494 1.0331251422535763 1.0235556482139718 1.0643777264773773 1.0045782742590115 1.0 16.823453669925506 -6.783260109924711 24.05827227429543 1.029052635760017 1.14666319388212 0.6369005902475151 0.044883847259607326 98.68159394501396 108799.53173591197 0.015212099254733527 0.013429296551342614 1.647175561025892e-07 6.783260109924711 0.11761055812210297 SLGNILQAKPTS(ph)SPAKGPPQK ddPTM_A459_Selumetinib_30min_R2 2 SLGNILQAKPTSSPAKGPPQK 21 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SLGNILQAKPT(0.032)S(0.597)S(0.371)PAKGPPQK;SLGNILQAKPT(0.153)S(0.423)S(0.423)PAKGPPQK 119.28 8.439399999999999e-05 47881000.0 162493.0 168320.0 175027.0 183598.0 155194.0 125816.0 121832.0 122912.0 92352.0 154530.0 True False 153462.2895710176 181229.60276589604 163765.95337498887 158591.63567578464 135697.14226803655 143146.01195606677 127497.42940552814 123269.65357082308 110824.98053047869 150068.31738284178 1.0226161807326553 1.2076473297395491 1.091276001697299 1.0567962541433638 0.9042357816397536 0.9538723059770478 0.8495959149076572 0.8214235737470676 0.7384968557203933 1.0 17.19525989990094 -6.3510487612487045 1.115115727467782 0.8433635706527748 1.1270492380060546 0.6506814739955473 0.07859721924304326 0.2792369279764267 0.7262334469738296 0.03392314994455509 0.04624568911165169 4.456062142934914e-07 6.3510487612487045 0.2836856673532798 SLGNILQAKPTSS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 SLGNILQAKPTSSPAK 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SLGNILQAKPT(0.003)S(0.036)S(0.961)PAK;SLGNILQAKPTS(0.007)S(0.993)PAK 202.01 2.4986e-06 76479000.0 4971.2 7313.1 4473.9 4461.200000000001 4362.6 5060.6 4914.4 4899.9 2651.0 5099.299999999999 True False 5087.019287728658 6456.878852232044 3866.368953373606 3682.135167095622 3968.003600279589 5009.694958657166 4543.7028513938585 4769.93873488169 4498.5533786207 5753.844826388236 0.884107834190907 1.1221850861565748 0.6719626736615657 0.6399434253438055 0.6896264532685282 0.8706691107973132 0.7896811590322294 0.8290002387631026 0.7818343237185458 1.0 12.490310598680049 -5.264197069271895 24.999912003906886 0.7727525902756218 1.0031464612851717 0.3721250682432069 0.11305270326508636 219.79929317494097 1992617.3062635069 0.029245054862934203 0.0657031526229439 5.442556305943319e-06 5.264197069271895 0.2303938710095499 SLGNILQAKPTSS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 SLGNILQAKPTSSPAK 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SLGNILQAKPT(0.002)S(0.012)S(0.986)PAK;SLGNILQAKPT(0.012)S(0.218)S(0.77)PAK 161.48 0.00022056 277542000.0 453583.0 366096.0 425391.0 389951.0 414668.0 306911.0 453032.0 459565.0 322088.0 396481.0 True False 428374.6726966134 394174.3860158247 398021.806190701 336839.0010970048 362573.6986610453 349185.2043893341 474098.8856658776 460902.2580649181 386514.59989064373 385033.5633486479 1.1125644969000277 1.0237403269150844 1.0337327549554225 0.8748302308180782 0.9416677743823979 0.9068954959470555 1.2313183337645321 1.197044366876586 1.0038465128315444 1.0 18.554624685351186 -7.253096731403721 24.92467914029982 1.124472669095657 0.979739288720656 0.29771524482154077 0.09326428521825147 693.1025906371065 2070733.910700939 0.037398686166129735 0.028457211376005365 5.583458192441808e-08 7.253096731403721 -0.14473338037500105 SLGNILQAKPTSS(ph)PAKGPPQK ddPTM_A459_Selumetinib_30min_R1 2 SLGNILQAKPTSSPAKGPPQK 21 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SLGNILQAKPT(0.085)S(0.238)S(0.678)PAKGPPQK;SLGNILQAKPT(0.166)S(0.166)S(0.667)PAKGPPQK 102.59 8.191100000000001e-05 957960000.0 13310.0 12973.5 19836.7 20205.6 13827.9 13854.1 12973.6 12454.9 8781.9 11151.7 True False 13620.0971032484 11454.556588783485 17142.9850951935 16677.071266086994 12577.168886514028 13714.740332516343 11994.990906894714 12124.555592783116 14902.242895401403 12583.129321756665 1.0824093717052388 0.9103106465716888 1.362378519431783 1.325351654556372 0.9995263153473014 1.0899308098823306 0.9532597655302613 0.9635564637978679 1.1843034045302951 1.0 13.619203132891766 -6.32813382839319 24.99995317202896 1.0289237618225577 1.1652911944468871 0.20656156387364366 0.13263135405965779 334.56853398995446 125409.52192720711 0.04404872430134004 0.04994656381151757 4.697493324497119e-07 6.32813382839319 0.13636743262432938 SLGNILQAKPTSS(ph)PAKGPPQK ddPTM_A459_Selumetinib_30min_R2 2 SLGNILQAKPTSSPAKGPPQK 21 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SLGNILQAKPT(0.009)S(0.185)S(0.805)PAKGPPQK;SLGNILQAKPT(0.028)S(0.227)S(0.745)PAKGPPQK 102.78 0.00023042 239154000.0 259305.0 290101.0 240710.0 275680.0 257431.0 181413.0 196115.0 190493.0 156276.0 264737.0 True False 244893.8661801596 312350.8138782642 225222.98066523153 238131.9084254739 225090.2163176604 206400.99404675062 205234.73609450014 191047.30309218616 187535.56671627134 257093.35494066766 0.9525484088714643 1.2149314942439837 0.876035791423737 0.9262468432154938 0.875519386215202 0.8028250831079788 0.7982887622352763 0.7431047882831368 0.7294454061620964 1.0 17.971932795934563 -5.766511814483131 1.0629395828764296 0.8007441656909351 1.0849014437175044 0.44085639060063464 0.10215653264535543 0.48260296050346074 1.044319143541746 0.03718090840236851 0.1066148100912041 1.711938604743692e-06 5.766511814483131 0.2841572780265693 SLGPPGPPFNIT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 SLGPPGPPFNITPR 14 0 Q9NZM1-5;Q9NZM1-2;Q9NZM1-6;Q9NZM1 Q9NZM1-5 MYOF Myoferlin 1 SLGPPGPPFNIT(1)PR;SLGPPGPPFNIT(1)PR;SLGPPGPPFNIT(1)PR 106.3 0.016 0.0 49817.5 37309.6 41936.2 52057.0 43504.8 39827.1 43123.0 45189.0 30593.0 39861.6 True False 47048.84278525332 40171.12635072768 39238.07054868221 44966.74679666612 38039.33808615336 45312.92151058266 45128.304946603406 45320.49250855833 36712.45483984028 38710.692035125176 1.2153965819717794 1.037726897630178 1.0136235878469573 1.1616105120483082 0.9826571442235482 1.1705531244305003 1.1657839881977579 1.170748703418569 0.9483802254562707 1.0 15.24044447862165 -8.270750486020102 24.975895729265986 0.9741900925364565 1.1095418962003245 0.3578761670738688 0.07505860012085863 837.6333100582245 2246820.0962420222 0.06900289732728096 0.01883394274544993 5.3610457569621465e-09 8.270750486020102 0.135351803663868 SLGS(ph)PLLHER ddPTM_A459_Selumetinib_30min_R1 2 SLGSPLLHER 10 0 H7C3L4;E7EQA9;Q92844;E7EV32;E7EMT6;E7ENY2;E7EVA2;E7EW82 H7C3L4 TANK TRAF family member-associated NF-kappa-B activator 1 S(0.017)LGS(0.983)PLLHER;S(0.038)LGS(0.962)PLLHER 95.183 0.015239 11463000.0 3052.0 4353.5 4198.4 4257.6 3591.8 3605.6 3540.8 3411.4 1903.37 2911.1 True False 3123.105661841781 3843.7901961127595 3628.2803401604306 3514.090085050282 3266.922324183793 3569.3309376228644 3273.714605285565 3320.918590211108 3229.879873355442 3284.7680415152677 0.9507842326671836 1.1701861889582967 1.1045773382788697 1.0698137709076188 0.9945671301273248 1.0866310474624343 0.996634941618403 1.0110055103553566 0.9832900931006058 1.0 11.681575780880602 -6.959171759641261 0.8317099594227495 0.9926373474846356 1.0807117865197815 0.21375320173617018 0.057216305294897504 0.8927633144340685 1.298703272562491 0.04031269471902852 0.031276645420278 1.0985712782439923e-07 6.959171759641261 0.08807443903514589 SLGS(ph)PLLHER ddPTM_A459_Selumetinib_30min_R2 4 SLGSPLLHER 10 0 H7C3L4;E7EQA9;Q92844;E7EV32;E7EMT6;E7ENY2;E7EVA2;E7EW82 H7C3L4 TANK TRAF family member-associated NF-kappa-B activator 1 S(0.023)LGS(0.977)PLLHER;S(0.013)LGS(0.987)PLLHER;S(0.001)LGS(0.999)PLLHER;S(0.001)LGS(0.999)PLLHER 105.66 0.008186399999999998 25671900.0 82701.0 73218.0 94120.0 98054.0 86006.0 62620.0 68819.0 67159.0 57310.0 64767.0 True False 78104.80949833366 78833.58516702344 88064.42167010764 84698.87604741547 75201.15737660456 71245.33659223719 72019.2198622615 67354.4215712291 68773.60137519192 62897.00842512477 1.2417889412230614 1.2533757509448202 1.4001368884649452 1.3466280538325532 1.1956237547629498 1.132730130989467 1.1450341067969265 1.070868444425471 1.093431994576704 1.0 15.940703779279216 -6.638992213129898 1.8638364230926594 1.0866241205002747 1.3122661570617327 0.7828424530446416 0.05519671142013696 0.16958928305358847 1.2083560454799098 0.023043612895241393 0.023044375503115153 2.296189818268319e-07 6.638992213129898 0.22564203656145798 SLGS(ph)VQAPSYGAR ddPTM_A459_Selumetinib_30min_R1 2 SLGSVQAPSYGAR 13 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.03)LGS(0.964)VQAPS(0.006)YGAR;S(0.001)LGS(0.633)VQAPS(0.364)Y(0.002)GAR 173.33 0.00015233 188200000.0 3872.2 4266.9 3273.2 4211.3 2812.3999999999996 3098.85 4217.9 5267.7 2537.21 3196.1 True False 3962.414726010402 3767.329364372007 2828.717418400608 3475.8755108916403 2558.0189165695497 3067.678382530677 3899.74040714923 5127.98348409892 4305.460059513476 3606.3505676503523 1.0987325418538099 1.0446375896358122 0.7843711711708615 0.9638207505590005 0.7093095550708419 0.8506323289943948 1.08135366598318 1.4219315033036175 1.1938551116284335 1.0 11.81632393035849 -7.497214676147137 5.202016289634278 1.236310203674378 0.9056697901745169 0.45912080211463213 0.14456158690867257 0.15183923901793264 11.66524317771649 0.06629933038849352 0.041524491448119795 3.182623929696035e-08 7.497214676147137 -0.3306404134998612 SLGS(ph)VQAPSYGARPVSSAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.273)LGS(0.39)VQAPS(0.184)Y(0.15)GARPVS(0.002)S(0.001)AASVYAGAGGSGSR 106.89 2.4126e-11 211520000.0 0.0 0.0 144.83 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 125.16288149424422 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SLGSASPGPGQPPLSS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 3 SLGSASPGPGQPPLSSPTR 19 0 Q9C0B5-2;Q9C0B5 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5 1 SLGSASPGPGQPPLS(0.103)S(0.896)PTR;SLGSASPGPGQPPLS(0.194)S(0.724)PT(0.082)R;SLGSASPGPGQPPLS(0.033)S(0.965)PT(0.002)R 235.54 1.2405999999999998e-24 31128200.0 7350.3 5664.900000000001 8844.7 5109.24 9146.4 6815.599999999999 7316.800000000001 9505.5 3391.1000000000004 6645.3 True False 7521.547688805908 5001.650874459439 7643.63832045945 4217.00714631302 8319.109734928075 6747.04125206967 6764.887885210522 9253.383261784507 5754.4490238553935 7498.288985703482 1.0031018680590695 0.6670389583538023 1.0193843335503736 0.5623959218367448 1.1094677400123683 0.8998107788235198 0.9021908728922972 1.2340659688400053 0.7674349488032591 1.0 12.872345713143137 -6.29799202279151 24.999845943978958 0.9887489070064146 0.8172987115314579 0.19088479148385207 0.17383244107731088 943.1976139222343 645088.9407634694 0.05025747878965294 0.056988227093225416 5.035098572734072e-07 6.29799202279151 -0.17145019547495666 SLGSASPGPGQPPLSS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 4 SLGSASPGPGQPPLSSPTR 19 0 Q9C0B5-2;Q9C0B5 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5 1 SLGSASPGPGQPPLS(0.068)S(0.931)PT(0.001)R;SLGSASPGPGQPPLS(0.375)S(0.622)PT(0.003)R;SLGSASPGPGQPPLS(0.227)S(0.773)PTR;SLGSASPGPGQPPLS(0.027)S(0.973)PTR 311.54 7.404699999999997e-117 69880300.0 300628.0 103253.0 196426.0 218181.0 140709.0 111628.0 335056.0 226036.0 148711.0 142642.0 True False 283920.29926923517 111172.17308927688 183788.1650124583 188464.3714167816 123031.87746557954 127003.74374190731 350636.76790086896 226693.72733772555 178457.35533251014 138523.55483157575 2.0496174792398336 0.8025506797341858 1.3267647169170447 1.360522198884706 0.8881657535800911 0.916838612005916 2.531242923466638 1.6364994936301753 1.2882816611910373 1.0 17.07977179041754 SLGSVQAPS(ph)YGARPVSSAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 SLGS(0.002)VQAPS(0.278)Y(0.241)GARPVS(0.152)S(0.048)AAS(0.202)VY(0.072)AGAGGS(0.002)GS(0.002)R 57.838 0.0014638 69763000.0 42455.0 41810.0 31580.0 40149.0 61880.0 32825.0 26278.0 25647.0 32381.0 50548.0 True False 40095.52106083061 45016.69255966095 29548.177181704224 34680.6369391119 54106.08118578106 37346.345794317844 27499.97906886915 25721.6285239106 38858.10480073443 49088.54790052349 0.8167999009072954 0.9170508088951005 0.6019362650853463 0.7064914001813866 1.102213927684833 0.7607954887970841 0.5602117040536024 0.5239843023271891 0.7915920609319967 1.0 15.583098870195176 -7.00441547718881 24.99781743343269 0.6765968198568508 0.826098223085913 0.06172197025348547 0.17429936533760235 396.6484011196403 2245597.7962437803 0.06284199584025166 0.05407308601174645 9.898844973994187e-08 7.00441547718881 0.14950140322906214 SLGSVQAPSYGARPVS(ph)SAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 SLGSVQAPS(0.001)Y(0.001)GARPVS(0.416)S(0.416)AAS(0.13)VY(0.034)AGAGGSGSR 110.62 1.2521e-11 234950000.0 1016.6 664.9 1632.5 1678.6 1049.8 937.22 1201.7 1086.5 722.16 684.47 True False 1040.2848020407453 587.053198896376 1410.8154666806167 1385.4640212244933 954.8457753572435 927.7924177276742 1111.0548015057798 1057.6824905506146 1225.4527755204542 772.3283918023961 1.3469462123657199 0.7601082714651468 1.8267041347375204 1.79387943772365 1.2363209555573937 1.2012926464641147 1.4385782178910864 1.36947249612601 1.5866991146869454 1.0 9.593070597485507 -5.2532123948261695 24.998208651944058 1.4427994584843673 1.0535272871828982 0.2291713655568569 0.27676010262160733 881.488977444909 2678444.667700606 0.0709764620837503 0.18100746411294338 5.58197137664832e-06 5.2532123948261695 -0.38927217130146907 SLGSVQAPSYGARPVS(ph)SAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 SLGS(0.002)VQAPS(0.105)Y(0.3)GARPVS(0.34)S(0.17)AAS(0.053)VY(0.019)AGAGGS(0.005)GS(0.006)R 54.308 0.0021642 80818000.0 6936.6 5940.0 8498.4 6085.8 8678.1 5715.8 7597.4 2922.6 2819.5 8960.5 True False 6551.09154140991 6395.578899889641 7951.6221963583075 5256.903541409431 7587.879494801667 6503.099567133642 7950.6941539625 2931.1042821375227 3383.4787834122094 8701.787082825054 0.7528443846138193 0.7349730393326634 0.9137918591518555 0.6041176934546146 0.8719909396287188 0.7473291986158775 0.9136852095192026 0.3368393473936773 0.38882573788667735 1.0 13.087096001803642 -7.753515032776719 24.99999633949111 0.5221243904860686 0.7880153708046189 0.19965444428863355 0.18938138652745504 207.5819891201911 654892.1602376968 0.08536926176664894 0.04814406840015971 1.7639447058009058e-08 7.753515032776719 0.2658909803185503 SLGSVQAPSYGARPVSSAAS(ph)VYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 2 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 SLGSVQAPS(0.007)Y(0.006)GARPVS(0.278)S(0.278)AAS(0.401)VY(0.031)AGAGGSGSR;SLGSVQAPSYGARPVS(0.033)S(0.033)AAS(0.93)VY(0.003)AGAGGSGSR 137.19 1.5803999999999999e-18 208063000.0 4412.5 476.20000000000005 2118.1 1734.41 1149.34 1452.38 628.0999999999999 803.05 2633.3 358.28 True False 4515.30266476961 420.4462826206263 1830.473653890483 1431.5278524079429 1045.3823999324584 1437.770375855529 580.7219113137892 781.7505053259746 4468.517771377552 404.26872794273294 11.169062439598912 1.0400168342483938 4.527863590155755 3.541030392562858 2.5858601659650087 3.5564719120673556 1.4364749761105733 1.9337397411474138 11.053335226093827 1.0 8.659170798561528 -4.750577516621115 24.993402956360576 3.393931902152979 11.169079017046796 0.41034950216867616 2.790859074324343 462.52744762061275 1064217.2009855378 0.662670493885353 9.607953718805744 1.7759162591623678e-05 4.750577516621115 7.775147114893818 SLGSVQAPSYGARPVSSAAS(ph)VYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R2 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 SLGSVQAPS(0.013)Y(0.012)GARPVS(0.035)S(0.073)AAS(0.709)VY(0.029)AGAGGS(0.093)GS(0.035)R 62.372 0.015907 0.0 8713.7 6876.1 6301.5 8827.8 5015.9 1675.0 2010.7 1627.9 5080.4 4146.2 True False 8229.427437704855 7403.474759853728 5896.068350554441 7625.438411195597 4385.757799285059 1905.7160458638962 2104.201534126465 1632.6369194866484 6096.621958236351 4026.4884328786625 2.043822446006974 1.8386926681323539 1.4643202008006657 1.8938185315346685 1.0892264742331679 0.4732948020668819 0.522589737733856 0.4054741362610659 1.5141287650186257 1.0 11.975306473550942 -6.41595304260997 3.593960685962074 0.731023320313784 1.786805954607144 0.6796530191859198 0.33169246064985747 0.14132239683189712 3.341036358794195 0.10843209019421078 0.12257193277596637 3.837487354619828e-07 6.41595304260997 1.0557826342933598 SLGSVQAPSYGARPVSSAASVYAGAGGS(ph)GSR ddPTM_A459_Selumetinib_30min_R2 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 SLGSVQAPS(0.001)Y(0.001)GARPVS(0.01)S(0.01)AAS(0.007)VY(0.019)AGAGGS(0.82)GS(0.132)R 64.777 0.00022502 26161000.0 14000.0 16462.0 13841.0 25766.0 18075.0 8862.4 2978.6 2989.2 1473.9 15453.0 True False 13221.936046440427 17724.58246632714 12950.485128941367 22256.62635117082 15804.256907449791 10083.115155142803 3117.1108019839307 2997.898077111301 1768.721184206864 15006.831738284203 0.8810611244950327 1.1811008996062529 0.8629726350501516 1.4830996135174577 1.0531374765221937 0.671901659923299 0.20771278417361155 0.19976888722376412 0.1178610658833901 1.0 13.87333180501358 -6.939929758286404 2.898741572227139 0.31906620451542417 1.1086249616754942 0.5833462326265129 0.2819255895242268 0.16769987365961875 2.862841140191959 0.10624450591687769 0.08915092457000147 1.1483393360373261e-07 6.939929758286404 0.78955875716007 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR ddPTM_A459_Selumetinib_30min_R1 1 SLGSVQAPSYGARPVSSAASVYAGAGGSGSR 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 95.287 1.5664e-07 10801000.0 373.28 259.15 554.85 565.77 543.2 335.91 433.68 336.33 195.45 216.65 False True 381.9766977235584 228.80859752443357 479.5044175728885 466.96889031823054 494.0676559097491 332.5310503818772 400.9671684422286 327.4094358461925 331.66437489679925 244.45913784970722 1.5625380220329361 0.9359789105740217 1.9614910769573541 1.9102124568782604 2.021064380148066 1.3602725318712217 1.6402216418219642 1.339321731746771 1.3567272543548998 1.0 7.9334495238753755 -8.342872305937492 0.9559142075393465 1.0182834064121493 1.6414345554492737 0.2957335022455144 0.30368891051865743 0.7386532003626364 1.4527097115929006 0.3084234451927653 0.10738393493945012 4.540751071137926e-09 8.342872305937492 0.6231511490371244 SLGTADVHFER ddPTM_A459_Selumetinib_30min_R1 4 SLGTADVHFER 11 0 E9PB61;Q86V81 E9PB61 ALYREF THO complex subunit 4 0 ;;; 164.9 0.00092353 37251100.0 15607.400000000001 23036.6 21848.8 24672.7 21219.699999999997 20876.5 21077.999999999996 16294.5 9004.7 13877.7 False True 15971.022053286177 20339.464162575212 18881.85296686765 20364.076108939335 19300.381881642315 20666.501364345382 19488.069490004847 15862.3169280046 15280.31822273323 15659.037975245248 1.0199235788644316 1.2988961515215087 1.2058118127510273 1.3004678921611976 1.2325394390225966 1.31978103616686 1.2445253355163173 1.0129815735219947 0.9758146220022762 1.0 13.934707961847904 -7.780023812827417 5.969176400211244 0.992496499339696 1.239783730870253 0.645861302078746 0.07979765416326785 0.0978553816609917 11.492497009101742 0.041465386074670894 0.020655701623834115 1.65949591302057e-08 7.780023812827417 0.2472872315305571 SLGTADVHFER ddPTM_A459_Selumetinib_30min_R2 2 SLGTADVHFER 11 0 E9PB61;Q86V81 E9PB61 ALYREF THO complex subunit 4 0 ; 147.58 0.00093301 21700000.0 127927.0 126697.0 148247.0 142664.0 153397.0 117694.0 106981.0 101341.0 99875.0 148571.0 False True 120817.3294723561 136414.25250493566 138708.94941912935 123232.9170908727 134125.8974734204 133905.2801802419 111955.82847882986 101635.8855320944 119852.79074066138 144281.36919618322 0.8373730450816388 0.9454737868438826 0.9613781057935699 0.8541152456302907 0.929613422860202 0.9280843460680452 0.7759548519850857 0.7044283409446813 0.8306879218597818 1.0 17.138525493575756 -7.2579470789765885 24.940149759201827 0.8031368053452231 0.9117588396224584 0.1764689866997151 0.07939553616690194 365.7823426715431 2612236.212307328 0.029910889401924802 0.02224614091908473 5.5214471686421685e-08 7.2579470789765885 0.10862203427723527 SLGVLPFTLNSGS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 SLGVLPFTLNSGSPEK 16 0 P42695 P42695 NCAPD3 Condensin-2 complex subunit D3 1 SLGVLPFT(0.002)LNS(0.085)GS(0.913)PEK;SLGVLPFTLNS(0.166)GS(0.834)PEK 223.18 4.1841e-11 108164000.0 12572.900000000001 17755.1 14634.5 14722.8 12327.4 14730.6 13634.6 13383.8 8185.2 12393.300000000001 True False 12865.824107395321 15676.324637877942 12647.215281554356 12151.739361184296 11212.388846579239 14582.423538314666 12606.13114472057 13028.818147290682 13889.686576645096 13984.10077596481 0.9200322790513976 1.1210105597080398 0.9043996095402697 0.86896823441591 0.8017954837575646 1.0427859303887617 0.9014616918656203 0.9316879473354468 0.9932484611751377 1.0 13.77149986627268 -10.316581541510715 15.138809198704077 0.9999999580044634 0.9420082399510454 0.038435088752859836 0.08571223715872701 0.0 0.0 0.08511311892072028 0.020642963496228635 4.824123956055077e-11 10.316581541510715 -0.05799171805341796 SLGVLPFTLNSGS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 SLGVLPFTLNSGSPEK 16 0 P42695 P42695 NCAPD3 Condensin-2 complex subunit D3 1 SLGVLPFTLNS(0.027)GS(0.973)PEK 177.07 1.1792e-06 22442000.0 135960.0 149220.0 153700.0 171860.0 151480.0 121100.0 141590.0 152900.0 108500.0 138790.0 True False 128403.88749100281 160664.69418207605 143811.10933590715 148452.3715249635 132449.72815161792 137780.4257636525 148174.2155552625 153344.91368604227 130203.03174329681 134782.77208027363 0.9526728491273967 1.19202693120444 1.0669843565040824 1.101419485841622 0.9826903402219225 1.0222406294002735 1.0993557505035823 1.1377189481954968 0.9660213225600581 1.0 17.04027657761278 SLHLS(ph)PQEQSASYQDR ddPTM_A459_Selumetinib_30min_R1 5 SLHLSPQEQSASYQDR 16 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 SLHLS(1)PQEQSASYQDR;SLHLS(0.999)PQEQS(0.001)ASYQDR;SLHLS(0.945)PQEQS(0.049)AS(0.006)YQDR;SLHLS(1)PQEQSASYQDR;S(0.002)LHLS(0.997)PQEQS(0.001)ASYQDR 218.83 2.0885e-39 4663600.0 4632.92 4432.620000000001 3492.0299999999997 3175.79 5044.3 3763.56 4791.97 3604.5899999999997 1342.73 2858.9900000000002 True False 4740.858021906954 3913.646789730867 3017.8315063477553 2621.1978934615354 4588.043955643496 3725.7020034390694 4430.507844862822 3508.9845638415445 2278.514740880939 3225.9692154208847 1.4695918359185038 1.2131692921999142 0.9354805656302662 0.8125303493076123 1.4222218655130299 1.1549093480586687 1.3733881351638328 1.087730331420331 0.7063039318506535 1.0 11.655516955960499 -4.862490228056849 3.4772616334988125 1.0826033352334763 1.4856597401351672 0.2538383684507347 0.21207585994816533 0.40205840950679467 8.148407754425508 0.05629609874553521 0.3753262702971898 1.3724918427293733e-05 4.862490228056849 0.4030564049016909 SLHLS(ph)PQEQSASYQDR ddPTM_A459_Selumetinib_30min_R2 4 SLHLSPQEQSASYQDR 16 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 SLHLS(1)PQEQSASYQDR;SLHLS(1)PQEQSASYQDR;S(0.008)LHLS(0.991)PQEQSASYQDR;S(0.1)LHLS(0.9)PQEQSASYQDR 187.56 8.689200000000002e-07 61830600.0 82916.6 75166.0 125792.0 153457.0 184771.0 119291.0 106447.4 129960.0 143234.0 135192.0 True False 78308.42731344885 80930.99050321635 117698.67967197395 132555.89187190947 161558.41510630195 135722.25243411952 111397.41502152142 130338.16208396369 171884.80229234401 131288.65568900018 0.5964599675614608 0.6164355181983712 0.8964878119460793 1.009652290034191 1.230558834336803 1.0337698388474763 0.8484923121263606 0.992760276201715 1.3092129048796797 1.0 17.00238273652984 -5.407614588790238 2.1360664669068163 1.0585913210461466 0.5836590019419369 0.6888097965297658 0.12118967331559681 0.19851542102877684 1.7215459915170888 0.03645780601764034 0.10685082528103346 3.911878984097744e-06 5.407614588790238 -0.47493231910420974 SLHPWYGITPTS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 SLHPWYGITPTSSPK 15 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 SLHPWYGIT(0.012)PT(0.035)S(0.477)S(0.477)PK;SLHPWYGIT(0.189)PT(0.241)S(0.285)S(0.285)PK 115.2 0.0015889 54779000.0 8433.3 9148.5 9141.2 10304.0 11356.3 8485.2 9778.7 7150.200000000001 2912.6000000000004 5230.0 True False 8629.779481654745 8077.389366977741 7899.875249017366 8504.599830035258 10329.124670117606 8399.846591945183 9041.084786123469 6960.553468877136 4942.469472112654 5901.321444514048 1.4623469612347773 1.3687424830054964 1.3386620815853374 1.441134822089933 1.7503070739723399 1.4233840116867043 1.5320441143785157 1.179490650411488 0.8375191079800006 1.0 12.526822328625173 -7.977259382847666 3.4279236755573015 0.9282075695725192 1.4713134263815535 0.7947180412956888 0.113868473786384 0.10851986698959327 2.6263082464832768 0.08335500440300599 0.03257082495971067 1.0537573506974603e-08 7.977259382847666 0.5431058568090343 SLHPWYGITPTS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 SLHPWYGITPTSSPK 15 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 SLHPWYGIT(0.001)PT(0.104)S(0.447)S(0.447)PK;SLHPWYGITPT(0.025)S(0.488)S(0.488)PK 124.04 0.00090745 21434300.0 121028.0 110394.0 163269.0 198465.0 190642.0 126161.0 123095.0 128849.0 123466.0 164598.0 True False 114301.74827347098 118860.86482734284 152764.45029384622 171433.72462877928 166691.84759889595 143538.53257446847 128819.16140811515 129223.92925789962 148162.64992827515 159845.62806303657 0.7150758494839474 0.7435978466703449 0.955699897113246 1.0724955490254187 1.0428301957258381 0.8979822239358511 0.8058973083537458 0.8084295505845115 0.9269108684652037 1.0 17.286319759950104 -5.237453112080733 7.241833538247322 0.9342809976269525 0.7277835000551504 0.50110612530948 0.08351021338400925 0.19433634181930756 43.84401099651168 0.025037469307243727 0.06419156219861157 5.788244768482084e-06 5.237453112080733 -0.20649749757180214 SLIEEGGDWDR ddPTM_A459_Selumetinib_30min_R2 1 SLIEEGGDWDR 11 0 Q15008-4;C9J0E9;Q15008;Q15008-3;Q15008-2;H7C531 Q15008-4 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 135.55 0.020618 2744700.0 13073.0 11332.0 13718.0 16752.0 15003.0 10395.0 11306.0 13351.0 8586.3 13677.0 False True 12346.454995365411 12201.127961877002 12835.398815029082 14470.348701188143 13118.189011478249 11826.81689358519 11831.751402413987 13389.84919962297 10303.799921266984 13282.10947288636 0.9295552803994755 0.9186137177068118 0.9663674916421087 1.089461634895226 0.98765855214921 0.8904321198171152 0.8908036352634283 1.008111642729383 0.7757653211864278 1.0 13.697196674155053 -6.753903663378767 24.944650200361366 0.9121408387215252 0.980522947711152 0.16202537260506533 0.07416457713665436 316.567469346326 1047896.8905675982 0.024815119390565684 0.024345433088004954 1.762366937049028e-07 6.753903663378767 0.06838210898962682 SLIEEGGDWDRR ddPTM_A459_Selumetinib_30min_R1 2 SLIEEGGDWDRR 12 1 Q15008-4;C9J0E9;Q15008;Q15008-3;Q15008-2;H7C531 Q15008-4 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 ; 201.09 0.00011461 25337600.0 5672.0 7601.7 7257.900000000001 8418.4 7309.8 6256.200000000001 7160.9 6260.9 3567.3999999999996 5260.3 False True 5804.1465642092335 6711.689430065549 6272.317044790964 6948.284472939516 6648.629880650009 6193.268308175107 6620.747547726333 6094.8405937306425 6053.617247412858 5935.510744661041 0.9778680915420853 1.130768642968539 1.0567442827785087 1.1706295838465897 1.120144527853886 1.043426349408249 1.1154469821626822 1.026843494338363 1.0198982880888647 1.0 12.535156462311273 -7.8597876461584075 5.668155037592977 1.0146206116738534 1.0909088487400438 0.2982478492584356 0.050883838125137554 0.2595186016228875 12.288926403296449 0.027927624296117993 0.013180295693063483 1.381059386185518e-08 7.8597876461584075 0.07628823706619037 SLIEEGGDWDRR ddPTM_A459_Selumetinib_30min_R2 3 SLIEEGGDWDRR 12 1 Q15008-4;C9J0E9;Q15008;Q15008-3;Q15008-2;H7C531 Q15008-4 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 ;; 181.4 0.00014083 41092800.0 61591.8 68512.9 70575.6 74640.9 86110.8 52801.7 56168.5 58909.2 49391.9 79677.1 False True 58168.77432751069 73767.61912630439 66034.84273290317 64474.68065726558 75292.7914636806 60074.65488889055 58780.44654577131 59080.61601905696 59271.66012499294 77376.61509703251 0.7517616821899662 0.9533580531249353 0.8534211873974271 0.8332579627115049 0.973069077385477 0.7763929038968066 0.7596668124091359 0.7635461430429357 0.766015159110599 1.0 16.23960999784289 SLIGS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 SLIGSPGR 8 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SLIGS(1)PGR 91.265 0.027107 98427000.0 4585.8 5418.4 5035.7 5444.8 4869.9 4214.7 4901.4 4164.9 2675.1 4051.3 True False 4692.640217586516 4784.011209054181 4351.879599120109 4493.967891554343 4429.418404850674 4172.303944641416 4531.683451860218 4054.4333224981656 4539.449318426339 4571.323818003779 1.0265385705350696 1.046526432936724 0.9519954771045955 0.9830780033248189 0.9689574795392482 0.9127124025231255 0.9913284711996467 0.8869276130756952 0.9930272934391774 1.0 12.158396303140542 -5.26345934158991 24.98745422509699 0.9573958622890051 1.0365325064120687 0.42474704224897697 0.034958095836703666 138.81373916985476 1717187.9604535396 0.008550747343944124 0.019356126118070777 5.451809328383638e-06 5.26345934158991 0.07913664412306365 SLIGS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 3 SLIGSPGR 8 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SLIGS(1)PGR;SLIGS(1)PGR;SLIGS(1)PGR 114.86 0.010127 270837000.0 1013313.0 858485.0 1087781.0 1209606.0 1211520.0 841337.0 767962.0 842751.0 810800.0 981512.0 True False 956997.1200733345 924328.0390356485 1017794.3547464047 1044855.5761132616 1059318.0264737797 957223.534853131 803673.7546878331 845203.2658850607 972982.6556448396 953173.1982855642 1.0040117806445337 0.9697377566828375 1.0677958177769498 1.0961864832043149 1.1113594343390416 1.0042493185654529 0.8431560561431753 0.8867257990523602 1.0207826420160637 1.0 19.862378860245187 -7.009243568821266 24.43171341631047 0.9275803216287082 1.0498301399689938 0.4236203703817303 0.06123681333422235 312.1235244545037 824976.2597485274 0.02359146042649272 0.01971411021765151 9.789408042812039e-08 7.009243568821266 0.12224981834028559 SLIPDIKPLAGQEAVVDLHADDS(ph)RISEDETER ddPTM_A459_Selumetinib_30min_R1 1 SLIPDIKPLAGQEAVVDLHADDSRISEDETER 32 2 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 SLIPDIKPLAGQEAVVDLHADDS(0.477)RIS(0.477)EDET(0.046)ER 41.88399999999999 0.01771 202070000.0 2607.3 3061.5 2017.3 2134.9 2307.1 2330.6 2550.2 2142.4 1168.8 2310.5 True False 2668.045017077352 2703.0581567472623 1743.3617402357177 1762.079792036322 2098.423212351587 2307.1562800154893 2357.8363608222003 2085.576592504037 1983.3682342255272 2607.0751811758532 1.02338629754206 1.0368163435655577 0.6687040530413165 0.6758837661296679 0.804895550194739 0.8849596270464692 0.9043990667575454 0.7999679516581458 0.760763728083584 1.0 11.348216471657404 -5.238094622234028 24.811055539038428 0.8060295438323491 1.030101407726724 0.45197928119285957 0.09565797813872555 652.6392989259375 693629.2959675955 0.025346926360786486 0.06697000881916665 5.779701080184636e-06 5.238094622234028 0.22407186389437495 SLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGT(ph)HDK ddPTM_A459_Selumetinib_30min_R2 1 SLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDK 41 3 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 SLIPDIKPLAGQEAVVDLHADDS(0.025)RIS(0.015)EDET(0.359)ERNGDDGT(0.6)HDK 46.033 0.0018881 12056000.0 41645.0 59255.0 46986.0 50058.0 44208.0 27817.0 24925.0 23658.0 23635.0 45442.0 True False 39330.5376181437 63799.667965144865 43962.971914488786 43240.01404513345 38654.1958154656 31648.539252415514 26084.061887950535 23726.840863207253 28362.660417076622 44129.971387504746 0.8912432159264897 1.4457219426888077 0.9962157357513437 0.9798332671789748 0.8759170831098796 0.7171665482062083 0.5910736188543315 0.5376581973022858 0.6427074282016737 1.0 15.429471191465243 -6.287859019917227 1.2254743935293537 0.6544434122663055 1.1548418590336165 0.5082605216905857 0.17740940226550042 0.3243923171540182 0.9995082267795473 0.07005693101699538 0.09903869209058053 5.15395924551734e-07 6.287859019917227 0.5003984467673109 SLKESEQES(ph)EEEILAQK ddPTM_A459_Selumetinib_30min_R2 2 SLKESEQESEEEILAQK 17 1 Q9BW71 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 SLKESEQES(1)EEEILAQK;SLKES(0.001)EQES(0.999)EEEILAQK 64.538 0.025023 18371100.0 87392.0 82949.0 96884.0 95437.0 83868.0 63529.0 63014.0 66213.0 50023.0 85550.0 True False 82535.10249789452 89310.92157692685 90650.5889193234 82438.31596199228 73331.75205056704 72279.54309115668 65944.27585987207 66405.66886784778 60028.99775940019 83079.94921440577 0.9934418987774637 1.0749997131851958 1.0911247512366666 0.9922769180953924 0.8826648637124055 0.869999846829753 0.7937447781737156 0.7992983806053322 0.7225449500996008 1.0 16.34221271383327 -6.322844845297562 1.6570515223503457 0.8186447559636097 1.0570660497676252 0.6441187328672846 0.07150674887812536 0.2125663373519055 1.1587825439683563 0.02544464336161123 0.03256303286375095 4.7550507307215913e-07 6.322844845297562 0.23842129380401544 SLKPGEELS(ph)PTDENGK ddPTM_A459_Selumetinib_30min_R2 1 SLKPGEELSPTDENGK 16 1 P42330-2 P42330-2 AKR1C3 Aldo-keto reductase family 1 member C3 1 S(0.003)LKPGEELS(0.627)PT(0.369)DENGK 64.374 0.032182 21296000.0 30802.0 9800.3 20319.0 24596.0 27673.0 31473.0 44482.0 46925.0 38364.0 18928.0 True False 29090.1481501756 10551.951497068769 19011.69766165447 21245.982369533387 24196.470340241125 35808.12006655186 46550.50113941083 47061.54398114807 46037.87197972194 18381.499459149905 1.5825775375302782 0.5740528143810509 1.0342843740199261 1.1558351056587826 1.3163491038374813 1.948052178557575 2.5324648428634595 2.560266864285757 2.5045765217377465 1.0 14.165966837908922 -6.7676853053642105 2.335456845913525 2.2809151129635223 1.0543773504890666 0.500886030700611 0.48625648786534265 0.20983697010576902 2.3490526166723824 0.1792657076045931 0.16491378419051472 1.7073190833786152e-07 6.7676853053642105 -1.2265377624744558 SLKPGEELSPT(ph)DENGK ddPTM_A459_Selumetinib_30min_R2 2 SLKPGEELSPTDENGK 16 1 P42330-2 P42330-2 AKR1C3 Aldo-keto reductase family 1 member C3 1 SLKPGEELS(0.033)PT(0.967)DENGK;SLKPGEELS(0.242)PT(0.758)DENGK 174.35 8.3699e-08 19951000.0 152489.0 70638.8 100466.6 110736.0 101544.0 128161.0 248366.0 226926.0 202489.0 90396.0 True False 144014.27184183267 76056.56882045853 94002.68833576355 95653.56576974485 88787.13490512219 145814.01442027613 259915.51112789218 227586.3170903781 242992.45801537644 87786.0326029859 1.6405146419264682 0.8663857628060935 1.0708160005463807 1.0896216964530112 1.011403890487497 1.6610161103842447 2.9607843459945995 2.5925117053602573 2.7680081991438743 1.0 16.421703794282948 -7.0292909947039135 4.356998467271515 2.4585105661260847 1.1248658114651036 0.5198975507650475 0.5343772676763782 0.1447120966518403 6.394629807496507 0.1935257074157843 0.15531793313480097 9.347791247966521e-08 7.0292909947039135 -1.333644754660981 SLKQPLEQNQTIS(ph)PLSTYEESK ddPTM_A459_Selumetinib_30min_R2 3 SLKQPLEQNQTISPLSTYEESK 22 1 Q9UQR1 Q9UQR1 ZNF148 Zinc finger protein 148 1 SLKQPLEQNQTIS(0.997)PLS(0.002)T(0.001)YEESK;SLKQPLEQNQT(0.064)IS(0.919)PLS(0.014)T(0.003)Y(0.001)EESK;SLKQPLEQNQT(0.012)IS(0.876)PLS(0.073)T(0.022)Y(0.018)EESK 119.72 1.8100000000000006e-05 9667600.0 39531.8 45993.7 44093.0 41142.4 37079.4 25573.2 24190.0 30904.199999999997 23249.1 40540.0 True False 37334.78081433386 49521.26889694514 41256.10438482852 35538.73414540132 32421.154277958147 29095.67616960393 25314.882931575667 30994.12610553429 27899.569634129723 39369.50486443032 0.9483172557769505 1.2578585650866738 1.0479203263260422 0.9026970054050634 0.8235093224972233 0.73904094729653 0.6430073992230275 0.7872622785646706 0.7086593984405558 1.0 15.264790947923395 -5.953244996473465 1.811089014654165 0.7592444814762981 1.1134575720426743 0.5870036808357186 0.11267455879106002 0.2130595962217603 1.4145936169201123 0.03506194170909343 0.05977043168898066 1.113666109206003e-06 5.953244996473465 0.3542130905663762 SLLGDS(ph)APTLHLNK ddPTM_A459_Selumetinib_30min_R2 1 SLLGDSAPTLHLNK 14 0 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 1 S(0.139)LLGDS(0.861)APTLHLNK 82.94200000000002 0.019056 2446500.0 36164.0 36931.0 48433.0 36048.0 46887.0 34977.0 35163.0 39127.0 34308.0 37077.0 True False 34154.14965596227 39763.4889481186 45316.873509863224 31138.200213731496 40996.63588490172 39794.764260406875 36798.14917416265 39240.85309217646 41170.5586456131 36006.490672384854 0.9485553581637092 1.1043422506769083 1.2585751253070314 0.8647940866287452 1.1385901574780253 1.1052108527457087 1.0219865498412752 1.0898272050231266 1.1434204743865477 1.0 15.135969375460222 -4.755860908476664 24.789074414078723 1.0831007557760672 0.9485551183405826 0.13939674048739592 0.09838322406426192 326.380564890398 1450169.7804223453 0.023634311498669975 0.20180978265204885 1.7544423072296157e-05 4.755860908476664 -0.13454563743548464 SLLGDSAPTLHLNKGT(ph)PS(ph)QSPVVGR ddPTM_A459_Selumetinib_30min_R1 1 SLLGDSAPTLHLNKGTPSQSPVVGR 25 1 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 2 SLLGDS(0.013)APT(0.424)LHLNKGT(0.903)PS(0.622)QS(0.038)PVVGR 65.111 0.007725399999999999 20797000.0 1724.1 1684.6 2433.8 2344.1 2209.5 2108.6 1616.5 2040.4 1025.2 1183.7 True False 1764.2681754853918 1487.3662488507075 2103.303327906454 1934.7469392066805 2009.6511151189095 2087.389398455616 1494.5661035483836 1986.2819638467324 1739.6895223545598 1335.6394252143944 1.3209165154751215 1.1135986410493672 1.5747538506276388 1.4485548290071766 1.504635964752481 1.562839011075577 1.1189892087143793 1.4871393628769967 1.3025143534343546 1.0 10.383314869071095 -9.304294473954991 0.8838693015736043 0.9955988674099331 1.3962191476638508 0.3547833117938345 0.15713074302386484 4.2517261067674985 3.879551694229349 0.20056499921628917 0.05200012655682316 4.962557204910824e-10 9.304294473954991 0.4006202802539177 SLLGDSAPTLHLNKGT(ph)PS(ph)QSPVVGR ddPTM_A459_Selumetinib_30min_R2 1 SLLGDSAPTLHLNKGTPSQSPVVGR 25 1 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 2 SLLGDSAPT(0.001)LHLNKGT(0.998)PS(0.812)QS(0.189)PVVGR 78.419 0.00035219 24321000.0 46915.0 48730.0 48831.0 57649.0 56414.0 43867.0 26041.0 25623.0 22406.0 46755.0 True False 44307.65211562518 52467.43430835391 45689.26662317286 49797.10674992807 49326.7689724411 49909.28106502178 27251.958099262567 25697.558687884008 26887.826075947476 45405.06166592101 0.9758306781219613 1.1555415273829173 1.0062593232301489 1.096730296642313 1.0863715885989764 1.0992008210943898 0.6001964780881832 0.5659624223607527 0.5921768430529026 1.0 15.470565514803019 -7.259203465604313 24.99681035030304 0.6534141255358519 1.0729411678234728 0.6860844334522037 0.12509488940011682 98.85502989128369 1105175.6427561606 0.04631872786273613 0.03410603655999602 5.505497051638456e-08 7.259203465604313 0.41952704228762094 SLLGDSAPTLHLNKGT(ph)PSQS(ph)PVVGR ddPTM_A459_Selumetinib_30min_R1 2 SLLGDSAPTLHLNKGTPSQSPVVGR 25 1 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 2 SLLGDSAPT(0.001)LHLNKGT(0.884)PS(0.193)QS(0.923)PVVGR;SLLGDSAPTLHLNKGT(0.98)PS(0.267)QS(0.752)PVVGR 87.79299999999998 0.00010933 106858000.0 9501.4 10359.7 14027.8 14239.7 13790.8 10098.099999999999 10922.8 8744.7 4661.3 7412.5 True False 9722.764133493938 9146.781507906131 12122.901809189809 11753.003707274167 12543.424574963492 9996.522282341206 10098.884402003265 8512.762149211198 7909.885652117937 8363.966578864321 1.1624585107816292 1.0935937418760109 1.449420163851956 1.405194962994462 1.4996980746743571 1.1951891710809008 1.2074276369686923 1.0177900723232063 0.9457098587775513 1.0 13.029971581811598 -7.620116230699193 1.737603319641746 0.9666409147893931 1.3150030009060685 0.5759442723756893 0.12091089722485043 0.2957304406409073 1.7406937027838771 0.09192922520055619 0.041481784382912744 2.3981910026880922e-08 7.620116230699193 0.3483620861166754 SLLGDSAPTLHLNKGT(ph)PSQS(ph)PVVGR ddPTM_A459_Selumetinib_30min_R2 2 SLLGDSAPTLHLNKGTPSQSPVVGR 25 1 P52594-2;P52594-3;P52594;P52594-4;C9J2I0;B8ZZY2 P52594-2 AGFG1 Arf-GAP domain and FG repeat-containing protein 1 2 S(0.001)LLGDS(0.004)APT(0.044)LHLNKGT(0.921)PS(0.492)QS(0.537)PVVGR;SLLGDSAPT(0.001)LHLNKGT(0.996)PS(0.243)QS(0.76)PVVGR 78.378 0.00035354 19817700.0 68894.0 72067.0 89559.0 96853.0 83534.0 62470.0 47318.6 40659.1 35627.4 75999.0 True False 65065.14728453329 77594.30716807197 83796.87144446645 83661.45431925583 73039.71211656489 71074.67545380154 49519.00866002711 40777.41124952365 42753.87551272925 73804.71140088387 0.8815852816105462 1.0513462581894564 1.1353864794526236 1.1335516761908768 0.9896348177535205 0.9630100044392337 0.670946443934392 0.5525041758924256 0.5792838248564338 1.0 16.17142529472043 -7.17248407357252 2.935087335508275 0.6589479889367424 1.046607617431129 0.5818138848137047 0.13426802884212197 0.17165381943847263 2.870730579553427 0.056622668192358436 0.041162196558184504 6.72226960536066e-08 7.17248407357252 0.3876596284943865 SLLGLDSGELQSGPESS(ph)SSPGVHVR ddPTM_A459_Selumetinib_30min_R2 2 SLLGLDSGELQSGPESSSSPGVHVR 25 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4 P49815 TSC2 Tuberin 1 SLLGLDSGELQSGPES(0.139)S(0.399)S(0.399)S(0.062)PGVHVR;SLLGLDSGELQSGPES(0.049)S(0.363)S(0.363)S(0.226)PGVHVR 120.72 5.1113e-08 9895800.0 60873.0 51571.0 68300.0 87056.0 84073.0 65144.0 57486.0 59761.0 55096.0 62222.0 True False 57489.92235392629 55526.32987309914 63905.65235941724 75198.82262002358 73510.99811784386 74116.99468164632 60159.212906347966 59934.894616033904 66116.7395108633 60425.489187828854 0.9514184018473142 0.9189223061231496 1.0575942903957387 1.244488437425351 1.2165561107720537 1.2265849342362505 0.9955933119440178 0.9918809995849605 1.0941862515228227 1.0 15.882869627242384 -5.396542328925614 4.3218502131796095 1.1162933661965138 0.9368811805971877 0.35798930327332734 0.09157019047759188 0.2560957270847068 7.702168368393828 0.027298826963734125 0.05995038276688451 4.0128938430431385e-06 5.396542328925614 -0.17941218559932604 SLLGLDSGELQSGPESSS(ph)SPGVHVR ddPTM_A459_Selumetinib_30min_R1 1 SLLGLDSGELQSGPESSSSPGVHVR 25 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4 P49815 TSC2 Tuberin 1 SLLGLDSGELQSGPES(0.018)S(0.012)S(0.6)S(0.37)PGVHVR 128.47 4.3558000000000005e-08 6731800.0 1069.9 1161.3 1549.0 1472.0 1397.1 1158.3 1515.0 1047.9 509.78 927.86 True False 1094.8265883369988 1025.3344561262775 1338.6543080479482 1214.9428328621786 1270.7325516780384 1146.6485536522532 1400.7223302665025 1020.1062879410852 865.0594271419316 1046.9598691217598 1.0457197268271534 0.9793445635947606 1.2786109071887117 1.1604483311106577 1.21373568286241 1.0952172929169837 1.3378949581338735 0.9743508973240773 0.8262584389863815 1.0 10.031990428240624 -7.977916666763988 20.07475089584534 0.908854237803359 1.1561621099008839 0.4892924880415018 0.10661119807965477 18.859789301795832 17144.085448514674 0.05852367572340315 0.028099663018378494 1.0521637455987248e-08 7.977916666763988 0.2473078720975248 SLLGLSNS(ph)EPNGSVETK ddPTM_A459_Selumetinib_30min_R2 1 SLLGLSNSEPNGSVETK 17 0 Q13033-2;Q13033;G3V340;G3V3G7 Q13033-2 STRN3 Striatin-3 1 S(0.016)LLGLS(0.151)NS(0.833)EPNGSVETK 113.07 0.0018562 3063000.0 14068.0 10742.0 12588.0 15532.0 13486.0 13724.0 14902.0 14756.0 11518.0 13692.0 True False 13286.156878665994 11565.876859026015 11778.101784778117 13416.51480580552 11791.768113630305 15614.35642593201 15594.972527752807 14798.937517012704 13821.921839809123 13296.676383911694 0.9992088620537966 0.8698321689636773 0.8857929188251151 1.009012659888363 0.8868207191909814 1.1743052154615563 1.1728474152098591 1.1129801981883736 1.0395020109335706 1.0 13.698778056578972 -6.757454809347806 24.999999798694454 1.111545764894631 0.9287021927150187 0.6196842957137801 0.06619169459438198 64.3267905204654 403599.1973680819 0.022236587160930125 0.021456965007124594 1.74801514323396e-07 6.757454809347806 -0.18284357217961222 SLLLEPPRGT(ph)PDR ddPTM_A459_Selumetinib_30min_R2 1 SLLLEPPRGTPDR 13 1 Q53GT1-3;Q53GT1 Q53GT1-3 KLHL22 Kelch-like protein 22 1 SLLLEPPRGT(1)PDR 86.214 0.037055000000000005 9500600.0 21894.0 18289.0 20640.0 22383.0 22347.0 18127.0 15678.0 13825.0 16023.0 19579.0 True False 20677.219128626213 19691.707491596237 19312.04487113284 19334.39678717132 19539.57007528522 20623.829709477515 16407.058065367633 13865.228461148037 19228.047720026178 19013.703397648766 1.0874903587263889 1.035658707815507 1.0156908660687831 1.0168664348452081 1.0276572462838294 1.0846824144752283 0.8629070161784753 0.7292229278627861 1.0112731495750542 1.0 14.214751940102929 -7.267579693859506 24.953576577469764 0.8782860078482573 1.040909607365552 0.4400989799630608 0.07775556391179547 402.8236870233402 1637024.1032710378 0.03084997550039095 0.021416816831676986 5.400330085925214e-08 7.267579693859506 0.16262359951729466 SLLNHT(ph)PPSGRPR ddPTM_A459_Selumetinib_30min_R2 1 SLLNHTPPSGRPR 13 1 B3KRP1;Q9UKI8;Q9UKI8-2;F8W7X8 B3KRP1 TLK1 Serine/threonine-protein kinase tousled-like 1 1 S(0.003)LLNHT(0.997)PPS(0.001)GRPR 80.102 0.021428 4866700.0 11466.0 13001.0 14388.0 22043.0 23819.0 14421.0 12357.0 14541.0 12698.0 18904.0 True False 10828.765622034709 13998.134895196166 13462.291744469929 19040.705373704033 20826.64427543826 16407.361849195964 12931.624984930972 14583.311902607853 15237.954811763866 18358.192401509397 0.5898601226744075 0.7625007184283159 0.7333124879638514 1.037177569407025 1.1344605078725456 0.8937351505177036 0.7044062237776603 0.7943762426963574 0.8300356853494472 1.0 14.16413639354298 -5.609381510667628 7.198738945151271 0.9043123198075511 0.6937037913700635 0.3973184025379497 0.12371631795990182 0.26950126961188364 18.82205587586188 0.03830473134464386 0.06671151803584054 2.45820721675932e-06 5.609381510667628 -0.21060852843748756 SLLPLSTS(ph)LDHR ddPTM_A459_Selumetinib_30min_R2 1 SLLPLSTSLDHR 12 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 1 SLLPLST(0.103)S(0.897)LDHR 104.09 0.0066783 1328200.0 6403.3 7424.8 8345.7 7090.8 9739.5 7512.2 5188.4 5473.8 4071.2 6706.9 True False 6047.430220440859 7994.25828550515 7808.746748111114 6125.020807687733 8515.936937765267 8546.93736103807 5429.67088061956 5489.727851763631 4885.553758832341 6513.254370381048 0.9284805838294111 1.2273830916014812 1.1989009340125427 0.9403933056171118 1.307478021508172 1.3122376119540444 0.8336340900964851 0.842854821811982 0.7500941128676538 1.0 12.669162855835172 -7.279602276694154 24.46209564876163 0.8435502696433331 1.1553989056521754 0.5297050916756922 0.13631923059607745 491.17774675956895 661523.3562108052 0.057185841469386364 0.0386481462361967 5.25288294733447e-08 7.279602276694154 0.3118486360088423 SLLSS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 SLLSSPTK 8 0 Q92667-2;Q92667;I3NI36 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 SLLS(0.122)S(0.878)PT(0.001)K;SLLS(0.132)S(0.856)PT(0.012)K 148.69 0.0015317 89040000.0 18070.3 25737.0 17081.2 16953.1 17281.2 23452.0 20733.3 23566.0 11373.0 18666.1 True False 18491.302831317018 22723.700075193312 14761.666860315434 13992.559334100408 15718.11851124367 23216.094172712284 19169.37048852441 22940.953126843793 19299.150348945 21062.075758211024 0.8779430405432953 1.0788917643283333 0.7008647689703906 0.6643485426001009 0.7462758510454973 1.1022699965202394 0.9101368121824961 1.0892066570361798 0.9162985913874728 1.0 14.362360006725172 -6.755629957078942 24.999938500398233 1.0033174812255718 0.8138376027680385 0.37943907960347023 0.12143813036893539 170.1494562434712 732211.0003591187 0.04386462598836552 0.04273972163404265 1.7553755418810732e-07 6.755629957078942 -0.18947987845753334 SLLSS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 SLLSSPTK 8 0 Q92667-2;Q92667;I3NI36 Q92667-2 AKAP1 A-kinase anchor protein 1, mitochondrial 1 SLLS(0.149)S(0.851)PTK;SLLS(0.115)S(0.885)PTK 145.9 0.0019262 85544000.0 1729250.0 946050.0 1277260.0 1559630.0 963240.0 1002430.0 2135380.0 1447170.0 1351890.0 1116790.0 True False 1633145.2077362244 1018608.992969798 1195082.482175538 1347205.7034881827 842229.1797251424 1140505.633346474 2234679.401175198 1451381.025108109 1622305.7749626313 1084545.3709311076 1.505833920377283 0.9392036702856409 1.1019202277812794 1.24218473435701 0.7765734862729339 1.05159789891254 2.0604757173567334 1.3382391036919594 1.495839471952975 1.0 20.048658977381052 SLLVTELGS(ph)SRTPETVR ddPTM_A459_Selumetinib_30min_R2 1 SLLVTELGSSRTPETVR 17 1 E5RG13;E5RIP7;H0YBL1;P29218;P29218-3 E5RG13 IMPA1 Inositol monophosphatase 1 1 SLLVTELGS(0.607)S(0.195)RT(0.195)PET(0.004)VR 61.276 0.031257 1621700.0 11697.0 9942.7 13875.0 13344.0 10191.0 10301.0 9411.5 7603.6 8799.0 11273.0 True False 11046.927566800976 10705.273119180592 12982.297605957758 11526.524180316046 8910.715471304053 11719.869246832239 9849.153398533452 7625.72521715626 10559.045864601532 10947.519199228484 1.0090804469728172 0.9778720570716183 1.1858666214417486 1.052889149637515 0.8139483758048149 1.070550234582661 0.8996698904376036 0.6965710749969433 0.9645149437459467 1.0 13.41831635947086 -6.204385148573626 10.349934810297784 0.900163300105933 1.0602525925787523 0.31055015533244723 0.10828619624865835 0.8588896017347625 153.21622896128136 0.03274970020121832 0.04228026040708307 6.246185120430544e-07 6.204385148573626 0.16008929247281922 SLMEKS(ph)T(ph)EPKMET(ph)MRMLK ddPTM_A459_Selumetinib_30min_R2 1 SLMEKSTEPKMETMRMLK 18 3 Q8WTQ4 Q8WTQ4 C16orf78 Uncharacterized protein C16orf78 3 S(0.54)LMEKS(0.73)T(0.73)EPKMET(1)MRMLK 61.222 0.031701 0.0 2893.7 1199.7 2384.8 2997.2 2291.0 1878.8 976.74 2288.7 2422.5 3061.2 True False 2732.8797383989063 1291.7131323564988 2231.3645643739164 2588.9761895416113 2003.184098200137 2137.587645951694 1022.1603453735923 2295.359738085317 2907.0676903054014 2972.8152020472126 0.9192901518119673 0.4345083850038737 0.7505897315236075 0.8708836619776189 0.6738340468726934 0.7190449122029705 0.34383581753406245 0.7721165232553407 0.9778837541948338 1.0 11.537614069005398 -8.176682245801688 4.035514425538197 0.9919711805265418 0.6701887119950637 0.35648699815778917 0.16621303007794755 0.24351430055387666 7.037109506486959 0.12841819277967845 0.042899282812684965 6.657600854621717e-09 8.176682245801688 -0.32178246853147807 SLMS(ph)S(ph)PEDLTKDFEELKAEEVDVTK ddPTM_A459_Selumetinib_30min_R1 3 SLMSSPEDLTKDFEELKAEEVDVTK 25 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 S(0.031)LMS(0.92)S(0.92)PEDLT(0.128)KDFEELKAEEVDVTK;S(0.044)LMS(0.935)S(0.942)PEDLT(0.08)KDFEELKAEEVDVTK;S(0.026)LMS(0.947)S(0.947)PEDLT(0.081)KDFEELKAEEVDVTK 65.438 0.0019971 10648400.0 3385.23 3170.87 5315.8099999999995 5578.849999999999 3532.57 3577.1900000000005 3118.2799999999997 3188.63 2189.2200000000003 2813.1099999999997 True False 3464.099272489075 2799.623066302528 4593.952199654202 4604.60857548449 3213.04966722589 3541.20671642865 2883.065629058368 3104.0571742700486 3714.946445697474 3174.2000705118394 1.0913298454846576 0.8819932594390905 1.447278715142057 1.4506358998164843 1.0122391770685666 1.115621774861101 0.9082810046669408 0.977902181751738 1.1703567397055847 1.0 11.632177349079203 SLMS(ph)SPEDLTK ddPTM_A459_Selumetinib_30min_R1 2 SLMSSPEDLTK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SLMS(0.628)S(0.371)PEDLTK;SLMS(0.933)S(0.067)PEDLTK 161.93 0.0023469000000000003 17741000.0 10998.2 14031.6 9402.3 10092.3 10253.5 10655.900000000001 11843.6 11549.3 6190.1 11300.3 True False 11254.436661228136 12388.773748886138 8125.519303137007 8329.869260934085 9326.072735402451 10548.711320783084 10950.227716662934 11242.975046586485 10504.14759298378 12750.803579243238 0.8826452851606148 0.9716072929751314 0.6372554680682532 0.6532819056591933 0.7314105873753844 0.8272977663898068 0.8587872637681108 0.8817463916461458 0.8238027923262231 1.0 13.638300550810616 -7.151773399470427 2.489952506791327 0.8846797125681682 0.7724786443540098 0.22017596591799982 0.1019455860851638 0.559377497244078 6.767657608054219 0.04995741833351412 0.03596756599553742 7.050608504964804e-08 7.151773399470427 -0.11220106821415843 SLMS(ph)SPEDLTK ddPTM_A459_Selumetinib_30min_R2 2 SLMSSPEDLTK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SLMS(0.63)S(0.37)PEDLTK;SLMS(0.607)S(0.393)PEDLTK 160.56 0.00060085 35166500.0 159297.0 116825.0 145451.0 136511.0 158795.0 110980.0 158716.0 157962.0 140262.0 125876.0 True False 150443.91045641567 125785.10184841877 136092.84101507452 117917.96630538999 138845.75245468825 126266.48762386569 166096.6084897874 158421.64326798322 168318.31924772597 122241.63281487483 1.2307092681284038 1.0289874157596557 1.1133100718736 0.9646301639635926 1.1358303162144359 1.032925401242686 1.358756461813034 1.2959712629812474 1.376931208883888 1.0 16.899376193523487 -7.256426026671725 24.99769471707835 1.2825790074707304 1.0800879908161627 0.33274208285864615 0.11823678602627205 405.38037048042 2021322.1901436325 0.043158761506525 0.03238863806332529 5.540819126087919e-08 7.256426026671725 -0.2024910166545677 SLMS(ph)SPEDLTKDFEELKAEEVDVTK ddPTM_A459_Selumetinib_30min_R1 1 SLMSSPEDLTKDFEELKAEEVDVTK 25 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.008)LMS(0.521)S(0.441)PEDLT(0.03)KDFEELKAEEVDVTK 73.831 0.0016936 12782000.0 3963.6 3420.3 7589.0 7407.2 4163.1 4846.3 3467.4 4524.7 2779.4 3206.4 True False 4055.944168176962 3019.8496859456686 6558.455483393074 6113.6715703646305 3786.548340055003 4797.55062208833 3205.8512263802436 4404.6902577030505 4716.438800655742 3617.9726729808503 1.1210543955920118 0.8346800705538807 1.8127432339033003 1.689805900420904 1.0465939580840622 1.3260328520214124 0.8860905032040887 1.2174470776403137 1.3036137160123613 1.0 11.820965795798715 SLMSS(ph)PEDLTK ddPTM_A459_Selumetinib_30min_R1 3 SLMSSPEDLTK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.001)LMS(0.346)S(0.653)PEDLTK;SLMS(0.053)S(0.947)PEDLTK;SLMS(0.371)S(0.629)PEDLTK 200.82 1.8938e-05 120566000.0 23119.8 31756.7 20417.6 20879.0 22248.5 22971.800000000003 24538.5 24529.4 13482.3 23008.6 True False 23658.446356700384 28038.61080071069 17645.002065848796 17232.874597370545 20236.12710329171 22740.724548725564 22687.541188940297 23878.800629279565 22878.47839176833 25961.977932743004 0.9112728782833828 1.0799874675707453 0.6796478339038677 0.6637735630934577 0.7794524421719847 0.875924192202828 0.8738756826507806 0.919760454736534 0.8812301763385373 1.0 14.664112679876359 -8.26548747586152 0.8360182361845102 0.9879963425855643 0.8280362247413813 0.16022536342492155 0.11305087578775298 1.2148228184587495 1.827205623111559 0.1196984187488694 0.045162320003969074 5.426408997244346e-09 8.26548747586152 -0.15996011784418307 SLMSS(ph)PEDLTK ddPTM_A459_Selumetinib_30min_R2 9 SLMSSPEDLTK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SLMS(0.386)S(0.614)PEDLTK;SLMS(0.045)S(0.955)PEDLTK;SLMS(0.017)S(0.983)PEDLTK;SLMS(0.009)S(0.991)PEDLTK;SLMS(0.068)S(0.932)PEDLTK;SLMS(0.019)S(0.981)PEDLTK;SLMS(0.022)S(0.978)PEDLTK;SLMS(0.342)S(0.658)PEDLTK;SLMS(0.291)S(0.709)PEDLTK 216.84 1.8067e-05 227853200.0 706775.0 600823.0 685756.0 700935.0 713002.0 522199.0 724600.0 743619.0 645287.0 578476.0 True False 667495.2749444955 646904.1921495624 641635.2055546796 605466.4438196816 623428.314441246 594127.1721994514 758295.3357676606 745782.8081772473 774362.4308252223 561773.8948188495 1.1881920486172415 1.1515383646621105 1.1421591702148821 1.0777760401538796 1.1097495276854714 1.057591279479148 1.3498230209009299 1.3275497759071442 1.3784236646932917 1.0 19.099630059580313 -7.262427950905957 24.99565297474326 1.2912449323745325 1.1210110170379692 0.29637450036590396 0.10444318553967248 93.28967554131297 2358746.4313676534 0.039868522075130745 0.02860120107073085 5.464772024763149e-08 7.262427950905957 -0.1702339153365633 SLMSSPEDLTKDFEELKAEEVDVTK ddPTM_A459_Selumetinib_30min_R1 1 SLMSSPEDLTKDFEELKAEEVDVTK 25 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 64.318 0.0012972 2968500.0 332.68 445.89 806.03 613.92 376.36 446.8 295.94 236.05 318.19 338.45 False True 340.4307967174062 393.68499151136274 696.5755532058668 506.7103967056718 342.3183044517548 442.30559766194153 273.61700753733925 229.78918720153942 539.9451903218859 381.89335428217595 0.8914289628247011 1.0308767803811378 1.8240054334414426 1.32683742993671 0.8963714623816688 1.1581913974211968 0.7164749123525392 0.6017103587294982 1.413863803251542 1.0 8.577026004137952 -6.260478472752187 24.913360760804423 0.9418106175436379 1.291023442385829 0.18488395119740686 0.30891008964211525 134.149655406454 3478079.1277700514 0.09702647295102011 0.11812660203152411 5.489357647562797e-07 6.260478472752187 0.34921282484219096 SLNDDGS(ph)SDPR ddPTM_A459_Selumetinib_30min_R2 2 SLNDDGSSDPR 11 0 P54259 P54259 ATN1 Atrophin-1 1 S(0.025)LNDDGS(0.944)S(0.03)DPR;SLNDDGS(0.5)S(0.5)DPR 110.98 0.0085117 15372100.0 47757.0 35270.0 42648.0 55891.0 57833.0 43032.0 53043.0 50806.0 51903.0 42920.0 True False 45102.85712641828 37975.09558907536 39904.07411163147 48278.5493826472 50567.50150642012 48959.26739439713 55509.604602710504 50953.83704861393 62285.050290989115 41680.78808044766 1.0821018316488096 0.9110935118544309 0.9573733115269564 1.1582926236774906 1.2132088627695885 1.1746243209197809 1.3317791519577795 1.222477774418959 1.4943347561176958 1.0 15.347094935213017 -5.972529229090645 2.1572967222293533 1.2550297703538145 0.9734833087991018 0.4513033888925706 0.12452816973535255 0.2597201789315729 2.436453051117816 0.037785869203262 0.06037416272416979 1.0652971641260864e-06 5.972529229090645 -0.28154646155471263 SLNFQEDDDTS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 SLNFQEDDDTSR 12 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 SLNFQEDDDT(0.035)S(0.965)R;SLNFQEDDDT(0.102)S(0.898)R 153.0 0.00048069 11990200.0 83430.0 56994.0 76199.0 91180.0 88846.0 75365.0 107835.0 121532.0 116523.0 62482.0 True False 78793.29459675185 61365.256535405766 71296.43929919811 78761.12670572668 77684.37118668242 85745.8446546463 112849.54117099868 121885.63799929418 139830.85592464646 60677.98231226772 1.2985483629178227 1.0113265833329974 1.1749968700719895 1.298018221838648 1.2802728143941 1.4131294645456662 1.8598103771849224 2.00872925160947 2.3044743842178783 1.0 15.888885492878591 -7.107580668086697 2.3087013952486464 1.886928912561536 1.201269546789732 0.4083358389495757 0.3222177582964396 0.2619183781617906 2.7413242167346663 0.13712257619621268 0.10061261538789255 7.805834370964691e-08 7.107580668086697 -0.685659365771804 SLNFQEDDDTSRET(ph)FASDTNEALASLDESQEGHAEAK ddPTM_A459_Selumetinib_30min_R1 1 SLNFQEDDDTSRETFASDTNEALASLDESQEGHAEAK 37 1 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 S(0.033)LNFQEDDDT(0.134)S(0.134)RET(0.295)FAS(0.295)DT(0.107)NEALAS(0.001)LDESQEGHAEAK 50.644 0.0036107 16965000.0 1384.7 1206.3 1954.3 2114.5 1947.6 1536.8 1605.8 1419.8 595.97 1175.5 True False 1416.960815842829 1065.065835206345 1688.9167942014883 1745.2422690808953 1771.4399238767066 1521.3411873027571 1484.6732131630024 1382.1422918396345 1011.3175620733986 1326.3868753396305 1.0682862158749924 0.8029827910756637 1.2733214008688298 1.3157867448243665 1.3355378862770466 1.1469814845033108 1.1193364777398311 1.0420355610694108 0.7624604712817622 1.0 10.373285921143891 -7.978469841758371 3.1501163738746176 0.8813612592817536 1.1562929389715089 0.32660214888717587 0.15339122732447916 0.3193495124568354 6.347415236641379 0.11964830874962527 0.04547630196855108 1.0508244235950193e-08 7.978469841758371 0.2749316796897553 SLNFQEDDDTSRETFAS(ph)DTNEALASLDESQEGHAEAK ddPTM_A459_Selumetinib_30min_R1 1 SLNFQEDDDTSRETFASDTNEALASLDESQEGHAEAK 37 1 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 1 S(0.005)LNFQEDDDT(0.129)S(0.129)RET(0.129)FAS(0.501)DT(0.106)NEALASLDESQEGHAEAK 78.22800000000002 7.6627e-07 18048000.0 1277.2 1596.1 1818.6 2239.6 2160.5 1613.0 1831.5 1867.0 589.99 1099.5 True False 1306.9562750014165 1409.2278699932406 1571.6441088547435 1848.495902498734 1965.0831564672546 1596.774684486821 1693.3484804508907 1817.4810951293125 1001.1699388353171 1240.6315350369407 1.0534604659734859 1.1358955743062582 1.2668097371940064 1.489963659873996 1.583937777632537 1.2870660138743577 1.3649084620442684 1.4649644506055504 0.8069841129788036 1.0 10.276858986345838 -8.264081916183331 24.99749416510905 0.9034920181668861 1.335653324474304 0.5405007304564853 0.15757469236108368 197.3669444447107 1866967.7972030481 0.1432137941357963 0.043469064899777025 5.443999589913214e-09 8.264081916183331 0.432161306307418 SLPAPVAQRPDS(ph)PGGGLQAPGQK ddPTM_A459_Selumetinib_30min_R1 2 SLPAPVAQRPDSPGGGLQAPGQK 23 1 Q5JVS0-2;Q5JVS0 Q5JVS0-2 HABP4 Intracellular hyaluronan-binding protein 4 1 SLPAPVAQRPDS(1)PGGGLQAPGQK;SLPAPVAQRPDS(1)PGGGLQAPGQK 99.343 2.9726e-05 306810000.0 6697.4 7652.4 7514.3 7083.799999999999 6241.7 6151.3 6504.0 6897.9 4085.5 6563.3 True False 6853.436389128156 6756.453450495759 6493.899333095353 5846.747309394769 5677.139337061639 6089.42350693353 6013.398043599555 6714.945284463029 6932.795106886028 7405.7634869558415 0.9254192901514439 0.9123236871385717 0.8768710133038136 0.7894860968343036 0.7665839379101265 0.8222546558041113 0.8119889399913011 0.9067188408447573 0.9361350951994515 1.0 12.85443276049563 -8.260836596247223 1.7678504554977204 0.9926332102000688 0.8422260612231361 0.5125457957125992 0.04943083673557339 0.3171332723667901 1.851834787426193 0.05295033250689714 0.015746144528243848 5.484832935152501e-09 8.260836596247223 -0.15040714897693264 SLPAPVAQRPDS(ph)PGGGLQAPGQK ddPTM_A459_Selumetinib_30min_R2 2 SLPAPVAQRPDSPGGGLQAPGQK 23 1 Q5JVS0-2;Q5JVS0 Q5JVS0-2 HABP4 Intracellular hyaluronan-binding protein 4 1 SLPAPVAQRPDS(1)PGGGLQAPGQK;SLPAPVAQRPDS(1)PGGGLQAPGQK 173.49 4.326e-13 333480000.0 382330.0 337420.0 369170.0 398080.0 387260.0 303950.0 337180.0 358300.0 315370.0 379220.0 True False 361081.62918825465 363299.0290236967 345418.00412190455 343860.81727369624 338608.936651674 345816.3535166155 352859.53810949513 359342.5936802419 378452.8121740412 368270.9332681113 0.9804782201623753 0.9864993302613028 0.9379453356706563 0.9337169627323157 0.9194560473366422 0.9390270104886387 0.9581520186188676 0.9757560568013405 1.0276477940183164 1.0 18.490408007746147 -7.993583504080027 2.6492015704985503 1.013337268647491 0.9491042632287535 0.5934124005940982 0.02062851817226091 0.21803526121913464 2.9276022950055554 0.01783717744640047 0.006343694789074964 1.0148842106962655e-08 7.993583504080027 -0.06423300541873755 SLPAT(ph)PQGK ddPTM_A459_Selumetinib_30min_R1 2 SLPATPQGK 9 0 Q13111;Q13111-3;Q13111-2;K7EPA1 Q13111 CHAF1A Chromatin assembly factor 1 subunit A 1 S(0.002)LPAT(0.998)PQGK;S(0.003)LPAT(0.997)PQGK 103.21 0.036108 30883000.0 11293.1 11872.4 12592.4 13407.7 12392.1 10855.8 11832.7 10934.4 6827.4 9344.900000000001 True False 11556.207257452632 10482.37388867098 10882.421245101994 11066.29688869989 11271.236743002954 10746.600508277757 10940.149912438583 10644.384192063177 11585.5991464334 10544.408942034293 1.0959559062039883 0.994116782296254 1.0320560692330745 1.0494942817121915 1.0689301605205417 1.0191752394425302 1.0375308822504699 1.009481351736117 1.0987433444703099 1.0 13.364190607891608 -14.522736782533661 0.002810577616807393 3.9283059336374074e-05 2.0285114349475766 0.060195521669339724 0.03447355890437174 701713.1081658695 149.43800331201032 56268.94892439425 51675.50485583036 3.0009808042073194e-15 14.522736782533661 2.02847215188824 SLPELDRDKS(ph)DSDTEGLLFSR ddPTM_A459_Selumetinib_30min_R1 1 SLPELDRDKSDSDTEGLLFSR 21 2 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.001)LPELDRDKS(0.693)DS(0.124)DT(0.182)EGLLFSR 59.983 0.0082914 26518000.0 2094.4 2463.1 3921.8 3353.0 2344.5 2498.2 2602.6 2511.3 1473.1 2026.5 True False 2143.1954450070216 2174.7191069358773 3389.2411009053862 2767.4614936052208 2132.4403889550927 2473.0703761841146 2406.2837866347195 2444.69216614796 2499.743109032874 2286.6210147815914 0.9372761953785029 0.9510623285965023 1.4822049998648825 1.2102842909757643 0.9325727241944265 1.0815392494852638 1.0523317030148776 1.0691287057822596 1.0932039427931346 1.0 11.15900155753771 -6.241588626478379 24.856547675042442 1.0444664187664525 1.1554107664925064 0.10966680438055465 0.14766985400223526 1916.5911932815177 2399899.88926962 0.04681236565354868 0.06033825455738653 5.73338853342563e-07 6.241588626478379 0.11094434772605388 SLPELDRDKSDS(ph)DTEGLLFSR ddPTM_A459_Selumetinib_30min_R1 1 SLPELDRDKSDSDTEGLLFSR 21 2 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.001)LPELDRDKS(0.414)DS(0.418)DT(0.166)EGLLFS(0.001)R 50.158 0.024461 45075000.0 3404.3 3259.1 5300.1 5857.8 4245.0 3838.6 3716.5 4142.4 2572.5 3000.6 True False 3483.6135663853115 2877.5230568855136 4580.375531365352 4834.845194524505 3861.0404995156196 3799.98716916994 3436.161412828685 4032.5300955884622 4365.344612033854 3385.756238319091 1.0289026501549925 0.8498907937666837 1.352836769382827 1.4279956542071781 1.1403775782253274 1.1223451724500106 1.0148874198145519 1.191027886163025 1.28932631434834 1.0 11.725262393032235 -5.252263856317561 24.988581133777775 1.1968937189937534 0.93939671431579 0.35840478094217376 0.13526720989743307 734.7323543331632 2000956.2944973302 0.03658229434455376 0.09398242253002147 5.594176231432083e-06 5.252263856317561 -0.25749700467796344 SLPESTSAPASGPSDGS(ph)PQPCTHPPGPVK ddPTM_A459_Selumetinib_30min_R2 1 SLPESTSAPASGPSDGSPQPCTHPPGPVK 29 0 H3BNC2;Q7LC14;O00221 H3BNC2 NFKBIE NF-kappa-B inhibitor epsilon 1 SLPESTSAPAS(0.001)GPS(0.059)DGS(0.94)PQPCT(0.001)HPPGPVK 159.53 5.238899999999999e-19 7830100.0 21392.0 17022.0 21320.0 23920.0 20975.0 17599.0 23430.0 24051.0 24765.0 17911.0 True False 20203.11827896099 18327.532665643346 19948.294411460865 20662.054735698428 18339.932981120844 20023.102502184305 24519.541425664214 24120.984428142598 29718.691991914635 17393.862891633227 1.1615084242545723 1.0536781150815688 1.146858207158593 1.1878933888594272 1.0543910283403863 1.1511590396527611 1.4096662471370043 1.386752590751146 1.7085734305868239 1.0 14.086290746680655 -7.2378888401163115 4.7679072232199555 1.4103236486260617 1.1210347705453045 0.34813967660882217 0.16549256451834904 0.19191730774438098 11.847602909284259 0.06314995398888816 0.046258464468073086 5.782440329702294e-08 7.2378888401163115 -0.2892888780807572 SLPS(ph)SSQLKGSPQAISR ddPTM_A459_Selumetinib_30min_R1 1 SLPSSSQLKGSPQAISR 17 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 S(0.004)LPS(0.469)S(0.131)S(0.365)QLKGS(0.025)PQAIS(0.005)R 66.738 0.022253 67776000.0 2416.6 3153.1 3235.6 4449.6 3609.7 2939.4 2873.9 2703.1 1236.6 2186.7 True False 2472.902078114955 2783.9335861635786 2796.2232918785944 3672.560889336654 3283.2032723442944 2909.8323047616636 2657.1194092098376 2631.4050070937583 2098.4198823094516 2467.3842452617328 1.0022363086997166 1.1282934919884224 1.133274356131742 1.4884430328957863 1.3306412564841605 1.1793186692950604 1.0768972908506103 1.0664755650227582 0.8504633545987716 1.0 11.268766688409988 -7.647834539786802 1.6376597830143036 0.9414155146783012 1.2210187443036766 0.4169950206322165 0.12985038664989912 0.4157361705368567 2.150629831824978 0.1025451290809473 0.04451310407270141 2.249911627895946e-08 7.647834539786802 0.2796032296253754 SLPSSSQLKGS(ph)PQAISR ddPTM_A459_Selumetinib_30min_R1 1 SLPSSSQLKGSPQAISR 17 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 SLPSSSQLKGS(0.999)PQAISR 237.39 9.6339e-22 24314000.0 823.85 1485.3 1041.8 1400.8 766.25 889.7 841.73 763.56 407.28 618.6 True False 843.0441020669564 1311.4003855027638 900.3292821977744 1156.1765762726504 696.9428227924249 880.7504257829663 778.2376284192891 743.3079084075722 691.1244134457332 698.0033356742618 1.2077938012324643 1.8787881353546378 1.2898638676677217 1.6564055172541539 0.9984806478312707 1.261814064157979 1.1149482941475086 1.0649059544816455 0.9901448576576161 1.0 9.44709012069277 -6.265410640775197 24.977226536540385 1.0866274792051167 1.5190861457475595 0.5625102739140724 0.18821139095219463 242.7313781695565 1526654.9009758404 0.053932197395065114 0.06343500798976637 5.427369118787502e-07 6.265410640775197 0.4324586665424428 SLPSSSQLKGS(ph)PQAISR ddPTM_A459_Selumetinib_30min_R2 1 SLPSSSQLKGSPQAISR 17 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 SLPSSSQLKGS(0.997)PQAIS(0.003)R 95.554 0.030133 8616200.0 13942.0 12912.0 12065.0 15033.0 14581.0 9798.7 8212.9 8480.6 9802.6 11242.0 True False 13167.159454248029 13902.308881376279 11288.751035378773 12985.479466628545 12749.204424206104 11148.38198125765 8594.816123552617 8505.277141961094 11763.393907528467 10917.414249776153 1.20606941836232 1.2734067392983028 1.0340132541558762 1.1894281163595852 1.167786083088998 1.0211559006736628 0.7872574885329502 0.7790560060625604 1.0774890132770825 1.0 13.41434357914405 -6.93926077933194 3.4821662545028036 0.8925325665788535 1.1725271801925432 0.6005101694046087 0.10078055962071177 0.15745720016978693 3.8919102010776983 0.038413220829933814 0.032686341756947485 1.1501095791698318e-07 6.93926077933194 0.2799946136136897 SLPTPAVLLS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 SLPTPAVLLSPTK 13 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 SLPTPAVLLS(0.999)PT(0.001)K 119.62 0.0031943 4151600.0 25203.0 24533.0 27833.0 25804.0 28348.0 24414.0 31885.0 32470.0 24792.0 25679.0 True False 23802.318155602738 26414.602213971826 26042.25508227911 22289.45068561717 24786.670805664566 27776.806891773827 33367.71567892887 32564.48232430213 29751.092746357688 24937.580547945392 0.9544758405828512 1.0592287476801003 1.044297582606695 0.8938096718229386 0.9939485010588464 1.1138533202276657 1.3380494396710043 1.3058396848761304 1.1930224220893346 1.0 14.606033880771498 -6.963735310760303 3.757646552092846 1.235007376991605 0.9919398116540437 0.5333940625378303 0.09575768700026635 0.15957787972385953 4.818777432895097 0.03555943965695868 0.02997024191879227 1.0870879687151392e-07 6.963735310760303 -0.24306756533756135 SLPTPAVLLS(ph)PTKEPPPLLAK ddPTM_A459_Selumetinib_30min_R1 2 SLPTPAVLLSPTKEPPPLLAK 21 1 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 SLPTPAVLLS(0.952)PT(0.048)KEPPPLLAK;SLPTPAVLLS(0.986)PT(0.014)KEPPPLLAK 149.32 1.1984e-06 102225000.0 4800.7 7086.3 5172.9 4921.1 4371.8 5248.4 5032.6 5121.0 3663.7 4833.3 True False 4912.546969463903 6256.6327016685045 4470.448592705764 4061.7222654878206 3976.371461903982 5195.605861165924 4652.986930230494 4985.174444647673 6217.031313939137 5453.701135328826 0.9007730433999489 1.1472269100223194 0.8197091262934089 0.7447643654647977 0.729114295637733 0.9526752075776626 0.8531796691404041 0.9140901418953711 1.1399655316030233 1.0 12.413019926904092 -8.131631852101819 5.338386190399091 1.0672806352490576 0.8787211634388462 0.3006389282336619 0.11513853356598626 0.30030276586512983 11.469172730737474 0.08796304807435484 0.03194086232702803 7.3853001073728065e-09 8.131631852101819 -0.18855947181021138 SLPTPAVLLS(ph)PTKEPPPLLAKPK ddPTM_A459_Selumetinib_30min_R1 2 SLPTPAVLLSPTKEPPPLLAKPK 23 2 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 SLPTPAVLLS(0.5)PT(0.5)KEPPPLLAKPK;SLPT(0.012)PAVLLS(0.654)PT(0.334)KEPPPLLAKPK 80.102 0.00023038 205692000.0 7708.1 8250.4 11462.900000000001 11334.2 8582.3 8493.2 7699.4 8607.0 5671.2 6589.2 True False 7887.683732648304 7284.439332493099 9906.301141202595 9354.894739284317 7806.032480328132 8407.766119208598 7118.628059177497 8378.714400523826 9623.612191940287 7434.988004243204 1.0608872170535772 0.9797513228448808 1.3323896602857992 1.2582259357977992 1.0499051882630033 1.1308378862763762 0.9574498378632005 1.126930453114656 1.294368220425913 1.0 12.860114699268927 SLPTPAVLLS(ph)PTKEPPPLLAKPK ddPTM_A459_Selumetinib_30min_R2 2 SLPTPAVLLSPTKEPPPLLAKPK 23 2 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;A0A3B3ISX8 Q8WX93 PALLD Palladin 1 SLPT(0.003)PAVLLS(0.9)PT(0.097)KEPPPLLAKPK;S(0.001)LPT(0.004)PAVLLS(0.497)PT(0.497)KEPPPLLAKPK 73.994 0.0004121 9645400.0 15051.0 18415.4 17140.7 17754.5 18748.6 11900.3 16742.5 13250.6 11084.7 18903.2 True False 14214.525673926777 19827.80196515617 16037.88602338309 15336.30647177918 16393.23325338938 13539.458304832302 17521.059424634357 13289.15705224508 13301.949732395577 18357.41549958804 0.774320637578082 1.08009768399049 0.873646185310944 0.8354284115933064 0.8930033344703266 0.7375470858158731 0.9544404235458716 0.7239122006332156 0.7246090678011883 1.0 14.164075338715705 -5.514445042089973 23.33579548500309 0.8317230102765094 0.9396248325951637 0.08590422224749117 0.11232519216918178 301.004386172725 832865.1411721273 0.028626824692053465 0.05300868328178402 3.0588273021296197e-06 5.514445042089973 0.1079018223186543 SLPTTVPES(ph)PNYR ddPTM_A459_Selumetinib_30min_R1 6 SLPTTVPESPNYR 13 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 1 SLPTT(0.003)VPES(0.997)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR 278.64 1.8957999999999997e-48 2108651600.0 17295.100000000002 21446.7 23874.199999999997 24204.100000000002 21526.399999999998 18811.199999999997 20265.9 18719.1 11028.7 15424.4 True False 17698.04217959365 18935.710393699672 20632.214771593488 19977.3083022279 19579.340920794595 18621.976407203027 18737.2268468303 18222.608659793834 18714.89839562207 17404.27198637906 1.016879200316135 1.0879920980618523 1.185468417624172 1.147839353341671 1.1249732787512048 1.0699658349270207 1.07658779761052 1.0470192992878542 1.0753048682684765 1.0 14.087153847526174 -7.136087457865142 1.6332700239700597 1.0481163752911449 1.1164887210783818 0.30085643028994713 0.045272591620762304 0.5351210898964984 2.822739147367496 0.025263622379834674 0.017017967073948856 7.309918621210044e-08 7.136087457865142 0.06837234578723694 SLPTTVPES(ph)PNYR ddPTM_A459_Selumetinib_30min_R2 7 SLPTTVPESPNYR 13 0 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YC33 Q6PKG0 LARP1 La-related protein 1 1 SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR;SLPTTVPES(1)PNYR 278.36 1.9599999999999998e-48 1909033800.0 494447.0 451049.2 591058.0 602517.0 587747.0 378182.0 424139.0 425950.0 366403.3 444875.0 True False 466967.6151681666 485643.22328823165 553029.9717752925 520453.1452002004 513908.9673351534 430273.13770561235 443862.303915484 427189.4439801817 439694.1981635818 432030.3028259361 1.080867735697481 1.1240952778349347 1.2800721804880129 1.2046681489605826 1.1895206516155095 0.995932773444756 1.0273869703401683 0.9887950942003604 1.0177392541391557 1.0 18.720772981741007 -6.7611359979494 24.999998681146735 1.0066090011354383 1.1803615520578998 0.7445777908053794 0.04971160057597914 4.4424487484160355 366090.5403187711 0.018381826930345537 0.017300724365983358 1.73326114749241e-07 6.7611359979494 0.17375255092246156 SLQARPVS(ph)MPVDR ddPTM_A459_Selumetinib_30min_R2 2 SLQARPVSMPVDR 13 1 Q4KWH8-2;A0A2U3TZV8;Q4KWH8;Q4KWH8-3;Q4KWH8-4 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 SLQARPVS(1)MPVDR;SLQARPVS(1)MPVDR 125.33 0.010155 11042300.0 42873.0 46399.0 52489.0 51936.0 50068.0 34406.0 29885.0 30505.0 24064.0 40126.0 True False 40490.29029421719 49957.65410370024 49111.914885702136 44862.22720540278 43778.010226400904 39145.114193428795 31274.71171600408 30593.76449962541 28877.472404338147 38967.458120131465 1.0390795871106357 1.2820352292337742 1.2603314985108 1.15127414949927 1.1234504978856754 1.0045590880665 0.8025853680162643 0.7851106019106744 0.7410663614576234 1.0 15.249982205922088 -6.938965623394746 1.803141505016916 0.8102261614473306 1.1925781438635503 0.7569023023659995 0.09032284413753873 0.15665466304795805 1.036513685937356 0.03975432949761039 0.0318159631858787 1.1508914842221744e-07 6.938965623394746 0.3823519824162197 SLQEEQSRPPTAVSS(ph)PGGPAR ddPTM_A459_Selumetinib_30min_R1 2 SLQEEQSRPPTAVSSPGGPAR 21 1 A0A087X0M4;Q9BWU0 A0A087X0M4 SLC4A1AP Kanadaptin 1 SLQEEQSRPPT(0.007)AVS(0.19)S(0.804)PGGPAR;SLQEEQSRPPT(0.008)AVS(0.171)S(0.821)PGGPAR 83.948 0.00068887 35129000.0 3370.9 3742.8 4438.1 4331.6 4015.0 3570.4 3989.0 3688.3 1764.44 3090.0 True False 3449.4354113704 3304.5912360194866 3835.430396738282 3575.167374202321 3651.8439589058253 3534.485017663823 3688.106518437675 3590.4743027131476 2994.1258104011704 3486.631599148834 0.9893317700133519 0.9477890456870214 1.100038902209972 1.0253929251014362 1.0473845185701074 1.0137248278615587 1.0577849748559685 1.0297831017161847 0.858744528998161 1.0 11.767618220282605 -8.230731753673615 24.342224873423525 0.9293722668843417 1.0275268614193138 0.38000354775247136 0.049559617556594084 420.8617126169283 333622.16045393376 0.0325831990951032 0.012311535882595799 5.878523332865926e-09 8.230731753673615 0.0981545945349721 SLQEEQSRPPTAVSS(ph)PGGPAR ddPTM_A459_Selumetinib_30min_R2 1 SLQEEQSRPPTAVSSPGGPAR 21 1 A0A087X0M4;Q9BWU0 A0A087X0M4 SLC4A1AP Kanadaptin 1 SLQEEQS(0.007)RPPT(0.004)AVS(0.284)S(0.705)PGGPAR 73.688 0.017266 4148600.0 16955.0 16533.0 17181.0 18282.0 17897.0 13505.0 15717.0 14120.0 13784.0 16371.0 True False 16012.708976242684 17801.027938026175 16075.5931652584 15791.960061790918 15648.61885878999 15365.19116381606 16447.871642644677 14161.086862308162 16541.185157139167 15898.326693033767 1.0071946114466899 1.1196793399538154 1.0111500081516318 0.993309570667619 0.9842934518163354 0.9664659344652093 1.0345662131758626 0.8907281335785597 1.0404356053638704 1.0 13.956587308662932 -5.482082115313015 6.242130946705339 0.9847721844868883 1.0645807202079174 0.29724142177364565 0.04626415587995953 0.21477003014719823 22.891134623253663 0.011378214340193864 0.0232893100040958 3.2954739628998715e-06 5.482082115313015 0.07980853572102908 SLQLPAS(ph)PAPDPSPR ddPTM_A459_Selumetinib_30min_R2 1 SLQLPASPAPDPSPR 15 0 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 SLQLPAS(0.91)PAPDPS(0.09)PR 74.296 0.040845 5560600.0 15532.0 8895.1 19425.0 17996.0 16938.0 12799.0 18134.0 16481.0 9572.2 13114.0 True False 14668.793619522337 9577.325567745514 18175.216648340866 15544.913755168436 14810.097012358754 14561.946072245977 18977.266931839313 16528.956981423573 11486.907469614602 12735.364745736038 1.151815743984375 0.7520260125217163 1.4271453555679399 1.22061001514488 1.1629110989787208 1.1434259138217067 1.4901235505008321 1.2978785697486739 0.9019692563937413 1.0 13.63655265909316 -5.260909154889161 24.999999875248633 1.2231121556414675 0.9519208933383243 0.21746504838051017 0.19008491460554036 62.45106638367876 2944362.0381851713 0.047845905819405316 0.11207359291110915 5.483916647236396e-06 5.260909154889161 -0.27119126230314317 SLQTLPT(ph)DSSTFDTDTFCPPRPK ddPTM_A459_Selumetinib_30min_R1 1 SLQTLPTDSSTFDTDTFCPPRPK 23 1 B0QY95;Q9NQG6 B0QY95 MIEF1 Mitochondrial dynamics protein MID51 1 S(0.145)LQT(0.069)LPT(0.702)DS(0.058)S(0.021)T(0.005)FDTDTFCPPRPK 90.882 0.0002204 21828000.0 1263.1 1838.4 1303.1 1249.4 1791.9 1805.4 1662.4 1586.5 766.63 1869.5 True False 1292.5277724352397 1623.1592733510274 1126.1461774159338 1031.2157441426673 1629.82296138564 1787.239315172043 1537.0038295940822 1544.4208663217207 1300.9151175601612 2109.4685354720855 0.6127267369484515 0.7694636094620747 0.5338530338230002 0.48885097208235334 0.7726225511208661 0.8472462542666324 0.7286213582939793 0.7321374272008704 0.61670278351368 1.0 11.042663853349037 -6.295105428912899 23.625087468402242 0.7699998729893113 0.6084285531793655 0.372618163794482 0.1145996341955177 399.2839867173647 280195.3700611467 0.0358644726252792 0.040669863516284065 5.068676466332134e-07 6.295105428912899 -0.16157131980994577 SLQTT(ph)SPPVVAPGNENGLAVPVPLRK ddPTM_A459_Selumetinib_30min_R1 1 SLQTTSPPVVAPGNENGLAVPVPLRK 26 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 S(0.064)LQT(0.147)T(0.394)S(0.394)PPVVAPGNENGLAVPVPLRK 70.679 0.00096767 6236600.0 1788.2 1221.3 1705.8 1459.2 1290.0 1283.9 1361.2 1176.2 667.13 946.15 True False 1829.861580768503 1078.309628233033 1474.1617292886958 1204.3781125764215 1173.3197277679974 1270.9851316879287 1258.5235880915925 1145.0033551639517 1132.070884752632 1067.5975687814473 1.7139993891678693 1.01003379903142 1.3808215496137741 1.128119946873891 1.0990281001737583 1.1905095785658517 1.1788370682860092 1.0725046484237082 1.0603910292197223 1.0 10.060152209837835 -4.753602774070495 24.999892861144666 1.1378299341183573 1.714000428297868 0.7376138462084068 0.10521156927479663 145.34672117595662 463639.6584284551 0.025419468504650006 0.26897273105578284 1.7635883688824637e-05 4.753602774070495 0.5761704941795107 SLQTT(ph)SPPVVAPGNENGLAVPVPLRK ddPTM_A459_Selumetinib_30min_R2 1 SLQTTSPPVVAPGNENGLAVPVPLRK 26 1 O94804 O94804 STK10 Serine/threonine-protein kinase 10 1 S(0.046)LQT(0.126)T(0.414)S(0.414)PPVVAPGNENGLAVPVPLRK 71.696 0.0071134 0.0 9882.9 8148.1 8622.9 11866.0 9267.8 7773.3 7188.4 4792.5 7097.1 8097.2 True False 9333.647982383301 8773.033069729086 8068.1120019036525 10249.830330008266 8103.496108816775 8844.001516008248 7522.674843544376 4806.445381558915 8516.718309542397 7863.412796947828 1.1869716398465235 1.1156775431062613 1.0260318528661345 1.3034836901843336 1.030531693816473 1.1247026888173839 0.9566679300448644 0.6112416460476969 1.0830816757894421 1.0 12.940939876615076 -7.35990970881381 3.9887775166436437 0.869861511622805 1.1294286207992 0.3782505717120227 0.13618597157874332 0.2180032437128552 6.205919852736276 0.05726789250875949 0.03745259235351712 4.366065946866361e-08 7.35990970881381 0.2595671091763949 SLS(ph)AIDR ddPTM_A459_Selumetinib_30min_R1 1 SLSAIDR 7 0 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 S(0.003)LS(0.997)AIDR 90.601 0.029436 6801500.0 3949.2 4551.1 4321.6 4515.1 4153.8 4670.3 3514.4 4654.8 2273.2 3042.1 True False 4041.2086761944847 4018.2550962510118 3734.750456849589 3726.6225439239324 3778.089523412952 4623.321022293118 3249.3059785403293 4531.339583078692 3857.4543720409556 3432.583167563324 1.1773083065786878 1.170621336788596 1.0880291239966557 1.0856612533497147 1.1006549117628202 1.3468926451606005 0.9466066282807367 1.3200960797973436 1.123775938917522 1.0 11.745078960308346 -8.550748268803595 22.594186289231143 0.9999999942318578 1.1528108932970125 0.1505318605503514 0.10977959386205108 4742.7002541175825 3844965.29789391 0.0998763595399033 0.02578796505513186 2.8135311719616468e-09 8.550748268803595 0.15281089906515466 SLS(ph)AIDR ddPTM_A459_Selumetinib_30min_R2 2 SLSAIDR 7 0 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 S(0.01)LS(0.99)AIDR;S(0.004)LS(0.996)AIDR 88.37 0.032367 18484100.0 128077.0 65658.0 88129.0 117927.0 72593.0 68971.0 138884.0 108711.0 99508.0 77035.0 True False 120958.99307285379 70693.75747625482 82458.87608759999 101865.13916457824 63473.21835034602 78471.12919359929 145342.38119342504 109027.33101192505 119412.3804858246 74810.79938903276 1.6168653999249516 0.9449672781683777 1.1022322547149312 1.3616368224440019 0.8484499413015385 1.048927826389503 1.9427994671947348 1.457374228083819 1.5961917458581576 1.0 16.190958926405656 -7.2238903637028455 24.975776619592885 1.537206185141075 1.1375692624225129 0.2420358377294768 0.2954101554264677 676.8195502016981 450187.9398822612 0.10793073453100004 0.08360072078483306 5.971860253191655e-08 7.2238903637028455 -0.3996369227185621 SLS(ph)APGNLLTK ddPTM_A459_Selumetinib_30min_R2 1 SLSAPGNLLTK 11 0 F5GZ00;Q96RR4-6;Q96RR4-5;Q96RR4-2;Q96RR4-3;Q96RR4-4;Q96RR4-7;Q96RR4 F5GZ00 CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1 S(0.01)LS(0.99)APGNLLTK 101.39 0.015321 2654600.0 26027.0 23224.0 24156.0 25526.0 27652.0 17808.0 21726.0 18224.0 20114.0 25906.0 True False 24580.52353433608 25005.206123070195 22601.82925906419 22049.314765193907 24178.10854798349 20260.89035507121 22736.30204925229 18277.02882285438 24137.362032116733 25158.026468128566 0.9770449826609374 0.9939255829445933 0.8983943668116141 0.876432608620039 0.9610494916448838 0.8053449812821649 0.9037394915716367 0.7264889734498302 0.9594298687416971 1.0 14.618731133391607 -5.336737040742499 3.9074337399989743 0.8794339214348676 0.9863861131028576 0.1882309772369002 0.07571316742243209 0.3067539629441365 8.919935927232178 0.019322561101994165 0.045186097765167875 4.605353369087607e-06 5.336737040742499 0.10695219166798997 SLS(ph)DFTGPPQLQALK ddPTM_A459_Selumetinib_30min_R1 1 SLSDFTGPPQLQALK 15 0 O95425-3;O95425;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 S(0.003)LS(0.994)DFT(0.003)GPPQLQALK 190.34 2.7325e-05 16486000.0 3219.8 4099.4 3676.3 4157.7 4104.6 2908.3 3338.7 2800.4 1603.1 2967.0 True False 3294.8150753598184 3619.440342240643 3177.078652470415 3431.63574469503 3733.33965472599 2879.0451425251217 3086.8591709972093 2726.124295018813 2720.34361420854 3347.843351027375 0.9841604668715209 1.0811259556484092 0.9489926258035472 1.02502876774146 1.1151476527658666 0.8599700883978368 0.9220440884875705 0.8142926681985372 0.8125659802373162 1.0 11.709016308971135 -6.779236958056945 24.9935650061991 0.8726846526122612 1.028806320512916 0.554007217969603 0.0666340985119437 176.5981086595319 247999.31539003542 0.022993655416366738 0.020321394080149435 1.6625053132158905e-07 6.779236958056945 0.15612166790065485 SLS(ph)DPIPQR ddPTM_A459_Selumetinib_30min_R1 2 SLSDPIPQR 9 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 S(0.032)LS(0.968)DPIPQR;S(0.009)LS(0.991)DPIPQR 112.83 0.0094646 12805700.0 2748.5 3540.0 3440.1000000000004 3451.4 3553.8 3062.1 3147.7 3044.1 1585.69 2154.28 True False 2812.534702349979 3125.5351542986496 2972.9533151166847 2848.6777808019892 3232.35941747435 3031.29805416435 2910.2664547721897 2963.360579369652 2690.8001157846306 2430.8028224641907 1.1570394259698995 1.2858036552426675 1.2230335128963266 1.1719082084634835 1.3297497384825285 1.2470357637199945 1.1972449710346929 1.2190871888019237 1.1069594336972473 1.0 11.247217156806919 -8.487606670315603 1.5637434702863469 0.9994364620719475 1.2355925501417717 0.7023358652751137 0.0482519183018203 0.21010267581960074 1.133584406979023 0.045152239852721154 0.013253204756351554 3.2538185421182776e-09 8.487606670315603 0.23615608806982424 SLS(ph)DPIPQR ddPTM_A459_Selumetinib_30min_R2 2 SLSDPIPQR 9 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 S(0.005)LS(0.995)DPIPQR;S(0.006)LS(0.994)DPIPQR 97.813 0.020257 9636600.0 53437.0 53202.0 59176.0 60089.0 67458.0 53899.0 51976.0 49474.0 38827.0 62536.0 True False 50467.18546525983 57282.4223286075 55368.68058595725 51904.77454069327 58983.32295782842 61323.098003592895 54392.986988490105 49617.96114913838 46593.48491702281 60730.423191958864 0.8310033556944164 0.9432244881210065 0.9117124116021055 0.8546750016318976 0.9712318778249224 1.0097591088697124 0.8956464343507509 0.8170198483930233 0.7672181827178856 1.0 15.890131802002925 -11.476508226785247 2.61330201414174 1.0799244822380425 0.8943453324129117 0.17901166411480052 0.07046335614457419 43097405.12222545 19862904.148919 20895016.59155112 0.018687745650370947 3.3380418189584986e-12 11.476508226785247 -0.1855791498251308 SLS(ph)DSESDDSK ddPTM_A459_Selumetinib_30min_R1 6 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.001)LS(0.655)DS(0.344)ESDDSK;S(0.08)LS(0.581)DS(0.08)ES(0.258)DDSK;S(0.008)LS(0.955)DS(0.036)ESDDSK;S(0.07)LS(0.927)DS(0.002)ESDDS(0.001)K;S(0.004)LS(0.937)DS(0.022)ES(0.037)DDSK;S(0.002)LS(0.646)DS(0.188)ES(0.164)DDSK 236.08 5.074999999999999e-09 2378273000.0 22134.0 27040.800000000003 26976.5 28731.0 22421.6 23600.9 22754.1 22697.999999999996 14935.6 21893.7 True False 22649.67913473329 23874.85056507314 23313.239471307585 23713.67019766526 20393.570238854987 23363.49637390269 21037.73991756898 22095.975306505152 25344.622346936 24703.96965769735 0.9168437076539245 0.9664378193418857 0.9437041817303059 0.9599133469740345 0.8255179439350018 0.9457385471902492 0.8515934972828938 0.8944301508085932 1.0259331879902562 1.0 14.592455265299312 -8.263581030083833 24.980190131906582 1.0129666060962021 0.913514763103801 0.45433274970865434 0.04380948109162296 179.0644814124439 2088528.1899449409 0.03732649145359209 0.011383279135189663 5.450281955695791e-09 8.263581030083833 -0.09945184299240117 SLS(ph)DSESDDSK ddPTM_A459_Selumetinib_30min_R2 7 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 SLS(0.663)DS(0.337)ESDDSK;SLS(0.991)DS(0.008)ESDDSK;S(0.039)LS(0.957)DS(0.004)ESDDSK;S(0.122)LS(0.876)DS(0.002)ESDDSK;S(0.298)LS(0.701)DSESDDSK;S(0.005)LS(0.945)DS(0.049)ES(0.001)DDSK;S(0.002)LS(0.998)DSESDDSK 253.42 9.224e-16 2663843700.0 1076267.0 1026834.0 1082727.0 1060765.0 980840.0 776829.0 907385.0 866560.0 705066.0 962782.0 True False 1016452.3887781656 1105588.8660082945 1013065.523604024 916286.9770783072 857618.1103791448 883830.1433984498 949580.2004492666 869081.5461332699 846098.9011900377 934983.9820519489 1.0871334785302131 1.1824682424846789 1.0835111007791969 0.9800028606558493 0.9172543346646279 0.9452890748553412 1.0156111962103183 0.9295149038018308 0.9049341137729003 1.0 19.83458212370215 -5.711569193596698 2.9396816478033947 0.9512261371088215 1.1350094143957716 0.7889291214487653 0.039021716989271565 0.1052757217690353 1.8448104106469758 0.011129341198940114 0.020366501104403058 1.942812130288598e-06 5.711569193596698 0.1837832772869501 SLS(ph)DSESDDSKSK ddPTM_A459_Selumetinib_30min_R1 2 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 SLS(0.657)DS(0.342)ESDDSKSK;S(0.016)LS(0.729)DS(0.09)ES(0.151)DDS(0.012)KS(0.003)K 233.52 9.157899999999999e-13 67737000.0 5582.4 3178.29 25677.1 20469.1 12129.6 9787.0 7336.2 9282.5 8517.5 5950.1 True False 5712.459058540485 2806.174329253066 22190.290854214312 16894.555937594585 11032.47982165481 9688.551665885012 6782.824527591499 9036.2979461906 14453.575406413349 6713.853293882032 0.8508465717810572 0.4179677759432396 3.305149797424843 2.5163725208278938 1.6432411223087204 1.443068718036133 1.0102729730142177 1.3459182902350406 2.1527988136982534 1.0 12.71292529734526 -6.666852116941446 4.278851863846007 1.3877852643114783 1.8148412412904429 0.04651646059718251 0.8052278597520991 0.8118701722940159 26.960032343076918 0.3004038222183382 0.29662780444219145 2.1535149104142625e-07 6.666852116941446 0.4270559769789646 SLS(ph)DSESDDSKSK ddPTM_A459_Selumetinib_30min_R2 2 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.216)LS(0.744)DS(0.04)ESDDSKSK;SLS(1)DSESDDSKSK 195.94 0.00060405 9504900.0 43502.0 88727.0 57247.0 96332.0 58846.0 25480.0 18532.3 16390.5 11057.3 52631.0 True False 41084.332992303694 95532.07559772865 53563.79034582086 83211.41541803085 51453.23939008526 28989.63871558931 19394.088671055797 16438.193641406644 13269.068966775603 51111.40627823956 0.8038192643076454 1.8690950328713802 1.0479811503176226 1.6280400301460247 1.0066880005215437 0.5671853080655992 0.37944736964345155 0.32161497478509266 0.25961071966092325 1.0 15.641357665716988 -6.660176430792065 2.7148486852413347 0.4398579674712338 1.3551483261743835 0.5784467781427927 0.3340265564115129 0.171137345606012 2.5590324536974927 0.11257157155064809 0.11076307708779551 2.1868730330520439e-07 6.660176430792065 0.9152903587031498 SLS(ph)EGLYPYPPEMGKPATGDFGYR ddPTM_A459_Selumetinib_30min_R1 1 SLSEGLYPYPPEMGKPATGDFGYR 24 1 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(0.063)LS(0.935)EGLY(0.002)PYPPEMGKPATGDFGYR 110.44 2.0259e-07 15691000.0 1621.7 1796.6 2059.1 2443.5 2039.1 1531.2 2160.7 2043.7 680.42 1325.9 True False 1659.4824547211058 1586.2532367833192 1779.4855298266823 2016.7885951757712 1854.663765032344 1515.7975182183636 1997.7166594104501 1989.4944371268205 1154.6230440894367 1496.0921803596898 1.1092113684613563 1.0602643724813485 1.189422385323115 1.3480376554677906 1.2396721200604408 1.0131712057033386 1.3352898207984485 1.3297940215478614 0.7717592934760495 1.0 10.54698335296968 -8.262941423122946 24.99987014516275 0.8858796354588507 1.2020148814622054 0.5220500058791231 0.12140988198144742 111.76850832965731 1860170.6810197965 0.10217636432213421 0.031751762226152266 5.458314769176437e-09 8.262941423122946 0.31613524600335463 SLS(ph)ELCLAVPAPGIR ddPTM_A459_Selumetinib_30min_R2 1 SLSELCLAVPAPGIR 15 0 A0A5F9ZHW8;O94827-5;O94827-3;O94827;O94827-7;O94827-2;O94827-6 A0A5F9ZHW8 PLEKHG5 Pleckstrin homology domain-containing family G member 5 1 S(0.005)LS(0.995)ELCLAVPAPGIR 101.61 0.010502 0.0 8010.6 7082.9 8758.6 10784.0 9569.5 5077.1 6722.2 7931.2 5020.7 6743.5 True False 7565.402920972555 7626.135654886929 8195.081211642642 9315.200596562374 8367.293857584556 5776.4244396749755 7034.795619786599 7954.278478919155 6024.980290078976 6548.797633282824 1.1552354103176221 1.1645092858158834 1.2513871508249002 1.4224291416824235 1.277683985081418 0.882058778288944 1.074211788746349 1.2146166249653652 0.920013203562489 1.0 12.677014335169858 -6.737405233010881 24.996848994256954 1.0350955819857648 1.2584478934650816 0.5377796899839049 0.10883054038123689 205.365180626292 213590.7575944054 0.03798219806142751 0.03796402451705107 1.8306055174346082e-07 6.737405233010881 0.22335231147931678 SLS(ph)ELESLK ddPTM_A459_Selumetinib_30min_R2 1 SLSELESLK 9 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 S(0.045)LS(0.955)ELESLK 116.55 0.0050537 0.0 10911.0 8744.1 6793.4 9982.7 7576.2 9415.5 7890.0 8146.3 8976.2 9074.5 True False 10304.610300193686 9414.744353287038 6356.3200400946625 8623.039038881969 6624.410023912648 10712.399659600902 8256.900633738405 8170.0043843074345 10771.690815983207 8812.495606617487 1.1693180638247058 1.0683403173803923 0.7212849031461155 0.9785013716666988 0.7517064767599135 1.2155920567559475 0.9369537305117208 0.9270931582845168 1.2223201345932608 1.0 13.105334917819718 -6.766441700361979 24.999965459941333 1.0481202086365933 0.9353100086289008 0.13210819741116675 0.1554197346988106 306.180835334261 1530182.3950277108 0.05484547758956232 0.04986997698429092 1.7122150088091226e-07 6.766441700361979 -0.11281020000769248 SLS(ph)EQPVMDTATATEQAK ddPTM_A459_Selumetinib_30min_R2 2 SLSEQPVMDTATATEQAK 18 0 P18615;P18615-3;A0A0A0MT02;P18615-4;A2ABK4;A0A0G2JI50;E9PD43;A0A0A0MSN9 P18615 NELFE Negative elongation factor E 1 S(0.027)LS(0.796)EQPVMDT(0.177)ATATEQAK;S(0.057)LS(0.943)EQPVMDTATATEQAK 200.73 1.5359e-10 22736300.0 118967.0 96992.0 117602.0 134859.0 144136.0 68737.0 80462.0 115510.0 68985.0 84351.0 True False 112355.29040263408 104430.97452156481 110035.61535537614 116490.97155524879 126028.347087811 78204.89781763974 84203.64243242823 115846.11497629005 82783.92760194754 81915.56745978184 1.3715987557285403 1.2748611498398932 1.3432808777086287 1.4220858765636026 1.5385152175096295 0.9547012886901634 1.0279321140486484 1.4142136662016913 1.0106006729745483 1.0 16.321850031205685 -6.7622293485077325 24.99999600742966 1.1040305666382706 1.3828474156669852 0.5624895519233837 0.13527034036787403 18.702001484849966 591845.1629750127 0.048013059380299185 0.044839479601623586 1.7289030939540074e-07 6.7622293485077325 0.2788168490287146 SLS(ph)ESAATR ddPTM_A459_Selumetinib_30min_R1 2 SLSESAATR 9 0 O14924-5;O14924-4;O14924;E9PBG5 O14924-5 RGS12 Regulator of G-protein signaling 12 1 S(0.001)LS(0.748)ES(0.251)AATR;S(0.016)LS(0.96)ES(0.024)AATR 104.07 0.014676 13942500.0 3353.3 3497.7 3798.2 3682.0 3694.8999999999996 3197.7 4830.0 5336.7 3369.2 3208.8 True False 3431.425365614037 3088.1876579633836 3282.4253020191845 3039.0078197000967 3360.696947387576 3165.5340412792993 4465.669211344691 5195.153379955328 5717.286323368111 3620.6807363588277 0.9477293402745262 0.8529301208338653 0.9065768403872546 0.8393470844259812 0.9281947766450386 0.874292507895283 1.2333783441606712 1.4348554203594002 1.579063921862869 1.0 11.822045253418015 -7.382052270395236 3.2222826389010697 1.3762806111826014 0.888126566276172 0.6826530162858118 0.14062774226673075 0.13260145429326467 2.5910998873986313 0.06207797724011423 0.03926264104344313 4.149041030023653e-08 7.382052270395236 -0.48815404490642933 SLS(ph)ESAATR ddPTM_A459_Selumetinib_30min_R2 2 SLSESAATR 9 0 O14924-5;O14924-4;O14924;E9PBG5 O14924-5 RGS12 Regulator of G-protein signaling 12 1 S(0.002)LS(0.99)ES(0.008)AATR;S(0.004)LS(0.989)ES(0.007)AATR 144.55 0.0019369 17819500.0 34543.0 31154.0 39597.0 43649.0 39784.0 27598.0 30404.0 50032.0 38673.0 56526.0 True False 32623.238346585134 33543.41162410134 37049.37212995386 37703.93090127514 34785.978246527404 31399.373990299562 31817.846244383043 50177.58483675655 46408.68061390333 54893.94750781422 0.5942957252608072 0.611058470869241 0.6749263591342167 0.6868504200013661 0.6336942381776347 0.5720006560983762 0.5796239419628865 0.9140822825615467 0.8454243631740457 1.0 15.744359469001703 -7.766412800807945 24.9966595404741 0.9098150981087423 0.6244568977285107 0.88299621622786 0.049672959015350175 42.06720368323113 211426.54581386573 0.027309269632095 0.013765525410935906 1.7123289496916984e-08 7.766412800807945 -0.28535820038023163 SLS(ph)ESSVIMDR ddPTM_A459_Selumetinib_30min_R1 3 SLSESSVIMDR 11 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 S(0.014)LS(0.984)ES(0.001)S(0.001)VIMDR;SLS(0.62)ES(0.086)S(0.293)VIMDR;SLS(0.722)ES(0.063)S(0.214)VIMDR 148.78 0.00064275 48822200.0 7468.8 8275.3 9095.2 8955.0 8132.900000000001 7432.7 8040.6 7273.6 4465.799999999999 6223.9 True False 7642.808508245047 7306.424028917399 7860.121796357454 7391.1773561690325 7397.280630980116 7357.933786351638 7434.0910684758055 7080.680500017441 7578.136430872994 7022.798190919883 1.088285367238205 1.0403864428803078 1.1192293417344936 1.052454755958308 1.0533238219125276 1.0477210915536586 1.0585653846763963 1.00824205786981 1.079076491286783 1.0 12.777830262743276 -7.6463549364909955 0.008906783784897855 4.037057712228851e-07 2.093945801769526 0.3786096892827019 0.02651270277895849 1414.4197720275547 11.05224328309416 1290.5011142950898 1306.2127279127137 2.2575899521905664e-08 7.6463549364909955 2.093945398063755 SLS(ph)ESSVIMDR ddPTM_A459_Selumetinib_30min_R2 6 SLSESSVIMDR 11 0 H3BSS6;Q9H2Y7;A0A0C4DGM5;Q9H2Y7-2;H3BNX5 H3BSS6 ZNF106 Zinc finger protein 106 1 S(0.108)LS(0.889)ES(0.002)S(0.002)VIMDR;S(0.003)LS(0.996)ESSVIMDR;S(0.008)LS(0.992)ESSVIMDR;S(0.004)LS(0.984)ES(0.006)S(0.006)VIMDR;S(0.006)LS(0.993)ESSVIMDR;SLS(0.995)ES(0.002)S(0.002)VIMDR 164.11 0.00059911 61762900.0 194978.8 190707.0 234448.0 243989.0 260546.0 195566.0 188947.0 188955.0 171270.0 221772.0 True False 184142.65885797836 205333.61368034626 219363.8709276819 210757.27729549835 227813.8821692066 222503.44132860837 197733.40989137779 189504.8277668159 205528.7856836352 215368.86612714492 0.8550105786844236 0.9534043493506891 1.0185495929489572 0.978587486136812 1.0577846569276854 1.0331272357502754 0.9181151084978276 0.879908183455542 0.954310571344604 1.0 17.71645018239503 -10.411889871028603 15.893060321707182 0.9999999999999981 0.9642902912458304 0.03234865891139316 0.0616772605428617 0.0 0.0 0.06513965706760363 0.015798687441543637 3.873558586814967e-11 10.411889871028603 -0.03570970875416768 SLS(ph)FEMQQDELIEKPMSPMQYAR ddPTM_A459_Selumetinib_30min_R1 1 SLSFEMQQDELIEKPMSPMQYAR 23 1 Q9Y6Y0 Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein 1 S(0.083)LS(0.917)FEMQQDELIEKPMSPMQYAR 84.03 0.00017401 57412000.0 702.87 969.07 962.84 1263.8 959.49 864.75 932.98 759.63 436.21 687.47 True False 719.2455034530577 855.6108338915799 832.091616501541 1043.101054464146 872.7042989117185 856.0514001301784 862.6045674534926 739.4821447740118 740.2165104821328 775.7134710248706 0.9272051218896488 1.1029985501749107 1.0726790852325714 1.3446989042049298 1.1250343477453135 1.1035664998819288 1.1120144224307742 0.9532929005306687 0.9542395976495814 1.0 9.599380045451252 -7.750932036571284 10.852453983299164 0.9652766116140324 1.1197990859634968 0.31745642102860205 0.0959151765960011 0.3104530692844617 307.6103847830965 0.04914546045344616 0.027099807645102503 1.7744671483271394e-08 7.750932036571284 0.1545224743494643 SLS(ph)FEMQQDELIEKPMSPMQYAR ddPTM_A459_Selumetinib_30min_R2 1 SLSFEMQQDELIEKPMSPMQYAR 23 1 Q9Y6Y0 Q9Y6Y0 IVNS1ABP Influenza virus NS1A-binding protein 1 S(0.133)LS(0.867)FEMQQDELIEKPMS(0.001)PMQYAR 56.688 0.0094545 4765500.0 6773.7 7494.8 8004.7 6985.9 9420.5 5612.8 6499.2 4949.6 4656.0 6256.1 True False 6397.244871269541 8069.627060419675 7489.686316858384 6034.408368650321 8237.012569661452 6385.91225207455 6801.425677920485 4964.002516549613 5587.330099509571 6075.470137700107 1.052962935587935 1.328230882141158 1.2327747725040474 0.9932413841037608 1.355781920241584 1.051097628222721 1.1194896071853941 0.8170565246871174 0.9196539482333257 1.0 12.568780337674287 -7.519664216213723 2.264269110432686 0.9033890751209968 1.1823394479574993 0.4603908837652243 0.12124441441566336 0.2549538782738505 2.5966751794178404 0.0660116660349594 0.03501587062411769 3.0222875615963804e-08 7.519664216213723 0.2789503728365026 SLS(ph)FSDEMSSCR ddPTM_A459_Selumetinib_30min_R1 2 SLSFSDEMSSCR 12 0 Q14153-2;Q14153 Q14153-2 FAM53B Protein FAM53B 1 S(0.131)LS(0.868)FS(0.001)DEMSSCR;SLS(0.9)FS(0.099)DEMSSCR 141.37 0.0009974 10433700.0 1887.94 2280.2 2538.0 2696.3999999999996 2462.4 1759.45 2062.67 2485.6000000000004 1347.71 1867.29 True False 1931.9253287082472 2013.2331239637795 2193.3535402360826 2225.524357696725 2239.6763547720298 1741.7515304527817 1907.0811412348567 2419.673813633326 2286.965437156132 2106.9748604448628 0.9169190221379026 0.9555088490893096 1.0409965403065995 1.056265264231407 1.0629820017402336 0.8266598539695112 0.9051276201901142 1.1484113356352248 1.0854260675294751 1.0 11.040957385277725 -7.762851870923782 24.99995993875156 1.0876890230988678 0.9706073068998522 0.2990773177310636 0.07766954686309833 49.7960121426528 881281.3608371178 0.043204305312458946 0.022510754755600246 1.7264266408374235e-08 7.762851870923782 -0.11708171619901564 SLS(ph)FSEPQQPAPAMK ddPTM_A459_Selumetinib_30min_R1 1 SLSFSEPQQPAPAMK 15 0 Q9H8N7 Q9H8N7 ZNF395 Zinc finger protein 395 1 S(0.164)LS(0.834)FS(0.002)EPQQPAPAMK 108.66 0.0055255 0.0 951.45 1268.2 1406.2 1306.5 1400.4 1180.9 1462.7 1231.2 695.19 1151.1 True False 973.6169338005774 1119.718554429815 1215.2457637036962 1078.3443010424166 1273.7340672607006 1169.021218171411 1352.367361373474 1198.544576498773 1179.6866553313178 1298.8548976635036 0.7495963833619957 0.8620813275170806 0.9356285801360791 0.8302269198678304 0.9806592480438018 0.9000398891934356 1.0411997243158058 0.9227701867659138 0.9082513046325988 1.0 10.343024552927456 -3.3572106474112946 0.5218709217705343 0.9575443581791909 4.953462880765439e-13 0.5756939804818295 0.05272813242976246 12.609496499814325 0.8193181831794406 0.027975170834692933 10.206894620969585 0.00043932847468490977 3.3572106474112946 -0.9575443581786955 SLS(ph)FSEPQQPAPAMK ddPTM_A459_Selumetinib_30min_R2 1 SLSFSEPQQPAPAMK 15 0 Q9H8N7 Q9H8N7 ZNF395 Zinc finger protein 395 1 S(0.019)LS(0.755)FS(0.226)EPQQPAPAMK 122.33 0.0015715 6914100.0 50464.0 48615.0 57053.0 50109.0 58749.0 44583.0 47625.0 49636.0 41503.0 56575.0 True False 47659.41290339787 52343.61417813719 53382.272094609594 43284.06775715354 51368.425397276216 50723.90356582093 49839.656867147176 49780.43254231786 49804.759690710045 54941.53275049693 0.8674569222491668 0.9527148508186415 0.9716196367697216 0.7878205355812912 0.9349652771893519 0.9232342278503715 0.9071399062250659 0.906061954412213 0.906504736897053 1.0 15.74560953861075 -10.98021771891189 2.43617914606688 1.0044037736671594 0.9075326552506287 0.2543270215154957 0.048050067791818654 3602899.839313932 3363814.771139137 107541.76627272072 0.01270419590865061 1.0466037369787667e-11 10.98021771891189 -0.09687111841653073 SLS(ph)GSPLK ddPTM_A459_Selumetinib_30min_R2 1 SLSGSPLK 8 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 S(0.039)LS(0.812)GS(0.149)PLK 128.86 0.004222399999999999 89955000.0 263300.0 280050.0 277240.0 246690.0 266560.0 204950.0 223900.0 234630.0 177370.0 260910.0 True False 248666.84007341214 301528.93449732277 259402.68023608823 213090.396436014 233072.34972336443 233180.00214913773 234311.79364943338 235312.7344549127 212848.95613187613 253376.8503744079 0.9814110472443086 1.1900413713871725 1.0237820852724948 0.841001836281161 0.9198644208378151 0.9202892916403932 0.9247561223655492 0.9287065259008376 0.8400489461344048 1.0 17.950925193960202 -5.565999907924782 6.107815416904904 0.9098780041330599 1.0911684134572848 0.5648778734946225 0.06358343353079754 0.11013424366782505 10.218453700989352 0.016072452596327176 0.028543645764809313 2.7164398447542147e-06 5.565999907924782 0.1812904093242249 SLS(ph)GSSPCPK ddPTM_A459_Selumetinib_30min_R1 1 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.094)LS(0.889)GS(0.017)SPCPK 122.7 0.0043834 17820000.0 2771.9 2906.3 3519.4 3874.0 3024.3 2386.7 2951.9 2767.3 2083.1 2623.8 True False 2836.479876821506 2566.0290448977867 3041.484810680406 3197.4786239864675 2750.7525989835326 2362.691964950214 2729.2358064116743 2693.9022145427657 3534.868556395616 2960.5902879762834 0.9580791669624731 0.8667288598895595 1.02732378169065 1.0800138867482774 0.9291230232548706 0.7980475969760868 0.9218552859190956 0.9099206416650739 1.193974245862936 1.0 11.53166913640587 -8.24505695665297 24.941898593883597 1.0969871328944132 0.9365456337933235 0.3607196560979473 0.08551982160630836 779.7281046823546 1187124.7491416587 0.061287437530246125 0.023001611509742677 5.687783320731259e-09 8.24505695665297 -0.16044149910108974 SLS(ph)GSSPCPK ddPTM_A459_Selumetinib_30min_R2 1 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.028)LS(0.966)GS(0.001)S(0.004)PCPK 123.62 0.0040969 3796500.0 16732.0 14651.0 16419.0 19156.0 19826.0 13016.0 13415.0 13849.0 13279.0 14252.0 True False 15802.102423502942 15774.684589609966 15362.619415655528 16546.919754056817 17335.280633311184 14808.835852516098 14038.824081318204 13889.29829717462 15935.171046260235 13840.507728856946 1.141728521314008 1.1397475366254326 1.1099751336163077 1.1955428282126603 1.2525032298611247 1.0699633382408524 1.01432869056153 1.003525200756613 1.1513429534839963 1.0 13.756609247702432 -6.943226841537852 9.48598683261183 1.0425176969226764 1.1645406681181798 0.5597715167732116 0.05364606066039621 0.28131449304524075 44.512436978199325 0.019446217405428238 0.01714241775879579 1.1396543655905377e-07 6.943226841537852 0.12202297119550343 SLS(ph)IEIGHEVK ddPTM_A459_Selumetinib_30min_R2 1 SLSIEIGHEVK 11 0 A0A3B3IU16;C9JTT8;Q68DU7;H7C1N3;O15155-2;O15155 A0A3B3IU16 BET1;DKFZp781C0425 BET1 homolog 1 S(0.248)LS(0.752)IEIGHEVK 77.633 0.032485 3453400.0 39209.0 15683.0 32459.0 35124.0 22649.0 15274.0 43053.0 38709.0 28139.0 21659.0 True False 37029.92074606308 16885.83567120695 30370.623278687082 30340.05060772041 19803.630135370986 17377.854856432932 45055.04980790105 38821.63678138007 33767.58626935133 21033.648393159743 1.7605086884548955 0.8028010811808719 1.4439065782122598 1.4424530657071915 0.9415214025262129 0.8261930850800142 2.1420463519088395 1.8456920100463918 1.6054079462663613 1.0 14.360411494107984 -7.257790965964424 24.98641746776193 1.7187609033426567 1.1946742761049582 0.23048222125011442 0.39010991641773285 402.7810645535354 2758486.3162132027 0.14917434720114112 0.1109331913240348 5.5234322841037324e-08 7.257790965964424 -0.5240866272376985 SLS(ph)KSDSDLLTCSPTEDATMGSR ddPTM_A459_Selumetinib_30min_R1 1 SLSKSDSDLLTCSPTEDATMGSR 23 1 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.014)LS(0.482)KS(0.482)DS(0.021)DLLT(0.001)CSPTEDATMGSR 69.292 0.0053551 7801900.0 2006.4 2167.8 2691.2 2641.2 2296.1 2338.7 2508.9 2126.2 1522.8 2115.0 True False 2053.1452162252117 1913.9929682171212 2325.749821703446 2179.9640014643933 2088.41816040938 2315.1748013697006 2319.6516530730214 2069.8062691290534 2584.0803790884956 2386.4808518445902 0.8603233563086281 0.8020148021459014 0.9745520563912325 0.913463856112412 0.8751036735933466 0.9701208369554799 0.971996758859425 0.8673047879387892 1.0827995443965848 1.0 11.22066904549818 -1.522878745373559 0.1742514060511719 1.0209510037325322 0.24332141840426516 0.40940211551981676 0.06052546965090941 59.72572705381705 0.6579075308012552 0.14434764893657856 12.185556832241252 0.029999999993560487 1.522878745373559 -0.7776295853282671 SLS(ph)LDPGQSLEPHPEGPQR ddPTM_A459_Selumetinib_30min_R1 1 SLSLDPGQSLEPHPEGPQR 19 0 P98174 P98174 FGD1 FYVE, RhoGEF and PH domain-containing protein 1 1 S(0.02)LS(0.979)LDPGQS(0.002)LEPHPEGPQR 123.14 0.0011044 0.0 645.43 597.04 406.31 571.55 556.83 453.02 588.26 526.82 0.0 376.81 True False 660.4672632118417 527.1382792436339 351.13533370107257 471.7395218222683 506.464824816321 448.4630301092495 543.8870745891572 512.8470222474687 0.0 425.1772339402179 1.5533928218384025 1.239808336769396 0.8258563856936046 1.1095126553473869 1.1911851914619036 1.054767269529548 1.2792008394918684 1.2061958668266268 0.0 1.0 8.73192053979318 -8.231742627269034 24.91005755740356 0.49999991413476186 1.1693363591597132 0.4814971055530849 0.28302922635319683 465.2929296003375 390295.506034345 0.18130752896937002 0.06850678965813581 5.864856261917072e-09 8.231742627269034 0.6693364450249514 SLS(ph)LDPGQSLEPHPEGPQR ddPTM_A459_Selumetinib_30min_R2 3 SLSLDPGQSLEPHPEGPQR 19 0 P98174 P98174 FGD1 FYVE, RhoGEF and PH domain-containing protein 1 1 S(0.2)LS(0.8)LDPGQSLEPHPEGPQR;S(0.009)LS(0.991)LDPGQSLEPHPEGPQR;S(0.234)LS(0.766)LDPGQSLEPHPEGPQR 169.72 3.0805e-07 16589100.0 77175.0 62618.4 89321.0 103610.0 120641.0 55181.4 69234.0 86938.0 80071.0 98534.0 True False 72885.92245600284 67421.02993010939 83574.18410535179 89498.13926278085 105484.99903577588 62782.13696312477 72453.51818456834 87190.97518663922 96087.43737066808 95689.06739792248 0.7616953998820692 0.7045844605187696 0.8733932347549066 0.9353016148710418 1.1023725270214733 0.6561056416408113 0.757176552711824 0.9111905629099301 1.0041631712334387 1.0 16.546066483866014 -1.5228787452803376 0.13005269702721795 1.0093705764557457 0.2023084807384832 0.19833833583810123 0.12420546460191291 173.22784192942825 1.5302777142041972 0.7392390302270822 25.626024995815193 0.029999999999999995 1.5228787452803376 -0.8070620957172625 SLS(ph)LESTDR ddPTM_A459_Selumetinib_30min_R1 2 SLSLESTDR 9 0 H0Y7V8;A0A0A0MRJ1;H0Y5V1;A0A0A0MRJ0;Q5VT25-3;Q5VT25-4;Q5VT25-5;Q5VT25;Q5VT25-2;Q5VT25-6 H0Y7V8 CDC42BPA Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase MRCK alpha 1 SLS(0.999)LESTDR;SLS(0.959)LES(0.04)T(0.001)DR 158.47 2.0346e-05 0.0 4593.8 5173.3 5068.0 5308.9 5860.8 4411.0 4885.1 4639.5 2337.9 4118.3 True False 4700.826602021225 4567.607630998078 4379.79343653131 4381.800275395397 5330.691674808284 4366.629344867557 4516.612973983426 4516.445388780101 3967.2455465399216 4646.923920639047 1.0115996479182223 0.9829314421764708 0.9425145561515885 0.942946420089617 1.1471441680231351 0.9396816946955862 0.971957589820472 0.9719215261348625 0.8537358507032206 1.0 12.182060309924918 -7.68979208341588 1.8168142646996597 0.9295436957671844 0.9950577747982808 0.12102391939282331 0.06609077114762124 0.7602905682018728 4.894071985702731 0.04686984622394071 0.020082924676486803 2.0427156518002213e-08 7.68979208341588 0.0655140790310964 SLS(ph)LESTDR ddPTM_A459_Selumetinib_30min_R2 2 SLSLESTDR 9 0 H0Y7V8;A0A0A0MRJ1;H0Y5V1;A0A0A0MRJ0;Q5VT25-3;Q5VT25-4;Q5VT25-5;Q5VT25;Q5VT25-2;Q5VT25-6 H0Y7V8 CDC42BPA Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase MRCK alpha 1 S(0.002)LS(0.953)LES(0.004)T(0.041)DR;SLS(0.524)LES(0.474)T(0.001)DR 108.9 0.01174 16866900.0 54256.0 47867.0 53733.0 68014.0 61467.0 38151.0 57377.0 47230.0 44261.0 51160.0 True False 51240.668723976545 51538.24498333628 50275.8772800669 58750.37586930575 53744.96593804794 43405.95394970359 60045.14419036862 47367.431480652594 53114.436755668685 49682.87787035653 1.0313546823451922 1.037344195676852 1.0119356896204312 1.182507503341697 1.0817603214993121 0.8736602187773407 1.2085681579688599 0.9533954857497202 1.0690692454303177 1.0 15.600461123338132 SLS(ph)LGDK ddPTM_A459_Selumetinib_30min_R1 4 SLSLGDK 7 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.001)LS(0.999)LGDK;SLS(1)LGDK;S(0.032)LS(0.968)LGDK;S(0.033)LS(0.967)LGDK 122.33 0.0080511 55150100.0 19258.4 29712.5 17656.800000000003 18188.899999999998 19773.2 20776.899999999998 25121.5 23551.4 12564.900000000001 24703.8 True False 19707.083249676853 26233.746687033487 15259.103541859926 15012.55006293946 17984.71755124201 20567.90324991582 23226.565029564306 22926.74036627129 21321.7175960133 27874.77336538933 0.7069863130850105 0.9411286091246424 0.5474162369623556 0.5385711971950872 0.6451969067333372 0.7378679991513016 0.8332467756815392 0.8224906464975332 0.7649108861450826 1.0 14.766672454861922 -7.1310818507794185 2.852047530673999 0.8424853740232671 0.6763954643507069 0.33717074466526786 0.11798555882684876 0.3897340939336685 6.105063033764906 0.053634524734686495 0.039843188065175277 7.394658959815383e-08 7.1310818507794185 -0.1660899096725602 SLS(ph)LGDKEISR ddPTM_A459_Selumetinib_30min_R1 1 SLSLGDKEISR 11 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 SLS(0.998)LGDKEIS(0.002)R 132.06 0.0098931 43222000.0 5092.6 5424.2 6304.2 6412.3 5263.4 4864.2 4954.1 4759.4 2746.4 4002.0 True False 5211.247671525376 4789.13214235783 5448.124266491845 5292.512178778637 4787.326399328742 4815.270564340233 4580.408248431206 4633.165251290008 4660.44021088038 4515.695682781113 1.15402986330467 1.060552454989242 1.2064861428253888 1.172025873877998 1.0601525735189352 1.0663408038547495 1.0143305860704586 1.0260136149025323 1.0320536498177224 1.0 12.14073254939661 -6.50259205780664 2.4490729998822727 1.0272643950477636 1.1455586831145586 0.6867569706628815 0.03829874195292417 0.18311809647401622 2.1984212266487506 0.01394040878306814 0.015142478377726466 3.143460027477639e-07 6.50259205780664 0.11829428806679498 SLS(ph)LGDKEISR ddPTM_A459_Selumetinib_30min_R2 1 SLSLGDKEISR 11 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.001)LS(0.999)LGDKEISR 127.78 0.013778 8767800.0 71381.0 66069.0 69005.0 68179.0 69793.0 60117.0 60247.0 62422.0 43951.0 59130.0 True False 67413.92978078316 71136.27985468172 64565.293426963355 58892.90258466494 61024.97938266358 68397.57106220897 63048.60487716569 62603.63768548159 52742.42809354494 57422.76326180964 1.1739931335839837 1.2388167307509665 1.1243849957653296 1.0256020302637203 1.0627315008236409 1.191122948060885 1.0979723248375552 1.0902233561984924 0.9184933830696116 1.0 15.809335136221137 -1.522878745362326 0.144632594950371 0.9587065697197333 1.8437630842786012 0.45825723736753865 0.06706528404030627 72.9775684674485 0.7004853633214169 0.28333612711303735 13.437387805106399 0.029999999994336436 1.522878745362326 0.8850565145588679 SLS(ph)MDSQVPVYSPSIDLK ddPTM_A459_Selumetinib_30min_R1 2 SLSMDSQVPVYSPSIDLK 18 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 S(0.012)LS(0.987)MDSQVPVYSPSIDLK;S(0.023)LS(0.959)MDS(0.018)QVPVYSPSIDLK 224.86 4.4615000000000004e-15 32569000.0 6487.4 8135.3 7507.799999999999 8245.3 7098.200000000001 6394.8 7837.099999999999 6735.5 3539.15 5326.6 True False 6638.543797717024 7182.815294001634 6488.281997393403 6805.413138450085 6456.169063288993 6330.474118013836 7245.941237314593 6556.852660012577 6005.67906071122 6010.320995477728 1.104524001748323 1.1950801462028589 1.0795233735894143 1.1322878001974601 1.0741804086914375 1.0532672252907953 1.2055830699835448 1.0909321922982267 0.9992276727366142 1.0 12.553226328213723 -8.197061373387827 4.144236336288599 0.9980018595159899 1.1195752848416347 0.5091676832162622 0.04664639039952546 0.175205945957041 5.789745503474116 0.036528832782521 0.012067258662463224 6.352411548495494e-09 8.197061373387827 0.12157342532564486 SLS(ph)MDSQVPVYSPSIDLK ddPTM_A459_Selumetinib_30min_R2 2 SLSMDSQVPVYSPSIDLK 18 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 S(0.005)LS(0.995)MDSQVPVYSPSIDLK;S(0.029)LS(0.97)MDS(0.001)QVPVYSPSIDLK 201.22 1.4062e-10 7883000.0 60522.0 67018.0 69524.0 76333.0 79439.0 50840.0 57660.0 71285.0 57567.0 68273.0 True False 57158.429528762 72158.06510316566 65050.9015320078 65936.31371823023 69459.16262632937 57842.7485204301 60341.30425112248 71492.42754813295 69082.00855637195 66301.78109544277 0.862094932962378 1.0883277026795501 0.981133545090828 0.9944878196154875 1.0476213682154554 0.8724162091085348 0.9101008035404047 1.0782881902556756 1.0419329226906737 1.0 16.01676000619272 -7.77527779345176 24.999846733374802 1.045082915948621 0.9712512927986482 0.19019267696701314 0.06981742941739782 424.0914282930465 766132.9514162294 0.03827730925046653 0.018538425062100142 1.677730526144114e-08 7.77527779345176 -0.07383162314997282 SLS(ph)MVDLQDAR ddPTM_A459_Selumetinib_30min_R1 3 SLSMVDLQDAR 11 0 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 S(0.023)LS(0.977)MVDLQDAR;S(0.061)LS(0.939)MVDLQDAR;S(0.024)LS(0.976)MVDLQDAR 214.61 2.0238e-05 30121300.0 6517.4 7754.199999999999 8267.0 8393.2 7350.4 6790.299999999999 6788.9 6961.7 4203.7 5720.2 True False 6669.242739347192 6846.3346591702175 7144.3868073804915 6927.485179876936 6685.55761781852 6721.995747099109 6276.807807225248 6777.053101211425 7133.371873899597 6454.443389466402 1.0332792987589512 1.06071650893141 1.106894332521387 1.0732893236282055 1.0358069959571254 1.0414524292008434 0.9724785591068855 1.0499825766961595 1.1051877665456329 1.0 12.656076972157305 -6.273294034273399 9.196131683082761 1.0339100175072176 1.0707352393599838 0.1766642120863161 0.0362495358900328 0.41414724644554585 287.7682406978515 0.011621310177349718 0.013645898970669864 5.329739292060124e-07 6.273294034273399 0.036825221852766266 SLS(ph)MVDLQDAR ddPTM_A459_Selumetinib_30min_R2 1 SLSMVDLQDAR 11 0 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 S(0.316)LS(0.684)MVDLQDAR 118.73 0.0052246 4918300.0 23841.0 22622.0 23515.0 28276.0 27913.0 21463.0 21680.0 29457.0 22365.0 19783.0 True False 22516.012663084726 24357.034658805307 22002.07050119616 24424.760021179307 24406.31939461388 24419.333428284663 22688.162958105015 29542.71499313115 26838.624930311773 19211.813387593105 1.1719878914514887 1.2678154928641436 1.1452365301135494 1.271340686504518 1.2703808277866868 1.2710582252508527 1.1809485393376202 1.5377369328503727 1.39698551036541 1.0 14.229706079803021 -6.625356174173544 1.0206332201911494 1.319122309299546 1.2071910792922165 0.025363984296180697 0.13620290790913747 1.3269898174375097 2.978153518313418 0.07144603156627218 0.07470466470940469 2.3694296887484127e-07 6.625356174173544 -0.11193123000732963 SLS(ph)NSNPDISGTPTSPDDEVR ddPTM_A459_Selumetinib_30min_R1 1 SLSNSNPDISGTPTSPDDEVR 21 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 S(0.003)LS(0.986)NS(0.011)NPDISGTPTSPDDEVR 294.28 4.295299999999998e-87 78087000.0 1678.6 2146.4 2284.4 2193.9 2219.8 1649.3 2038.6 1852.1 1029.5 1750.2 True False 1717.7081140129792 1895.0984901657105 1974.191027310996 1810.7765496034885 2019.0194819375215 1632.7095394445844 1884.826760713723 1802.9762915313336 1746.9863082949864 1974.8552183916802 0.8697893891238664 0.959613885877202 0.9996636760636939 0.9169161023754353 1.0223632918173153 0.8267489810084717 0.9544126289160193 0.9129663150697576 0.8846148781062189 1.0 10.94753117422284 -6.745301534703213 24.999998356929886 0.9127254191595907 0.954512892484472 0.09756291138399242 0.05726847631503048 545.2018591515558 844599.14463542 0.018052308512692565 0.017999901597178573 1.7976223757865827e-07 6.745301534703213 0.04178747332488131 SLS(ph)NSNPDISGTPTSPDDEVR ddPTM_A459_Selumetinib_30min_R2 1 SLSNSNPDISGTPTSPDDEVR 21 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 S(0.005)LS(0.942)NS(0.053)NPDISGTPTSPDDEVR 201.61 8.4985e-17 4627500.0 11468.0 9834.3 13706.0 12728.0 12187.0 11842.0 7026.1 10911.0 10426.0 14404.0 True False 10830.654470041352 10588.55918774153 12824.170881964474 10994.424442975318 10655.96010683765 13473.128009027023 7352.827571953029 10942.749203586716 12511.491326779815 13988.119093913514 0.7742752544017135 0.756968046715359 0.916790227182474 0.7859830452658351 0.7617864871821297 0.963183678847103 0.5256480533649717 0.7822888216864057 0.8944370034870373 1.0 13.771914363759413 -8.496017718601868 3.2059879602522123 0.9982434795951859 0.7843502944917092 0.2905482074312695 0.10863133863911487 0.28358409575751115 6.858388629771525 0.1038819591676047 0.02760930754230047 3.191407647517195e-09 8.496017718601868 -0.21389318510347666 SLS(ph)PDEER ddPTM_A459_Selumetinib_30min_R1 2 SLSPDEER 8 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SLS(1)PDEER;SLS(1)PDEER 119.22 0.0079825 41471000.0 5342.1 9196.5 6451.9 7945.4 7271.0 8115.7 7760.8 6491.6 3041.3 5640.9 True False 5466.560536082892 8119.769504663145 5575.76741774987 6557.885043629863 6613.339333799313 8034.063426466024 7175.396607744075 6319.42168031143 5160.863972236565 6364.964462018986 0.8588516980264306 1.2756975397294725 0.8760091986407132 1.0303097657122946 1.0390221930165409 1.2622322519484415 1.127327049594872 0.9928447704650484 0.8108236900665309 1.0 12.635936743704336 -8.006072962105954 7.067903028378139 0.9034623737736307 1.0721125769481339 0.18391552332064853 0.13613835128114954 0.20819992184338035 61.90728450911189 0.08084253778523035 0.034604911333183136 9.861138031579383e-09 8.006072962105954 0.1686502031745032 SLS(ph)PDEER ddPTM_A459_Selumetinib_30min_R2 1 SLSPDEER 8 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 S(0.177)LS(0.823)PDEER 99.788 0.018368 26906000.0 214910.0 193900.0 287660.0 284640.0 328320.0 273450.0 203430.0 226680.0 280220.0 246530.0 True False 202966.1625528936 208771.50651323242 269152.2687805269 245871.54096861207 287073.50638195954 311115.2553680492 212889.89808889764 227339.60127110593 336271.83000098274 239412.0383381348 0.8477692431916616 0.8720175809136754 1.1242219507792182 1.0269806926807672 1.1990771574172465 1.2994971244037612 0.8892196882272959 0.9495746448222528 1.404573605969001 1.0 17.86913617147208 -5.246970458622224 7.5096331754784735 1.1088132062544047 0.8585599274200953 0.3109152697171963 0.14987342806079898 0.20464161688773844 69.55750260047364 0.038820439070614166 0.09671542047881479 5.662778068144947e-06 5.246970458622224 -0.25025327883430937 SLS(ph)PGAASSSSGDGDGK ddPTM_A459_Selumetinib_30min_R2 2 SLSPGAASSSSGDGDGK 17 0 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.001)LS(0.999)PGAASSSSGDGDGK;S(0.008)LS(0.992)PGAASSSSGDGDGK 170.0 9.2822e-07 14865200.0 50735.0 36740.0 42924.0 40542.0 49782.0 43629.0 48475.0 58341.0 38145.0 41839.0 True False 47915.35180829684 39557.83986228038 40162.31657211754 35020.10966114909 43527.94010327333 49638.49872537067 50729.18355139026 58510.76265112754 45775.06586035067 40630.999359222995 1.1792806616611151 0.9735876667109589 0.9884648963969165 0.861906185263438 1.0712987814658008 1.221690322861897 1.2485339851695043 1.4400522648686942 1.1266044789016492 1.0 15.310293229052343 -6.6798284853899474 3.57375529688419 1.2393731906189156 0.9950564835383753 0.3573729515841486 0.12780840510347208 0.21928891349175006 5.513212339796121 0.043816445055013045 0.04283307241471622 2.090121413226799e-07 6.6798284853899474 -0.24431670708054032 SLS(ph)PGAASSSSGDGDGKEGLEEPK ddPTM_A459_Selumetinib_30min_R1 4 SLSPGAASSSSGDGDGKEGLEEPK 24 1 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.022)LS(0.977)PGAASSSSGDGDGKEGLEEPK;S(0.023)LS(0.977)PGAASSSSGDGDGKEGLEEPK;S(0.038)LS(0.958)PGAAS(0.001)S(0.001)S(0.001)S(0.001)GDGDGKEGLEEPK;S(0.035)LS(0.965)PGAASSSSGDGDGKEGLEEPK 153.31 2.2518e-10 71831000.0 13741.800000000001 16588.5 12451.2 13547.8 10184.380000000001 13568.399999999998 13969.3 13606.0 7744.490000000001 13573.5 True False 14061.957203111864 14646.310708215577 10760.39542954591 11181.931053702609 9263.20462719833 13431.914215121504 12915.584454252043 13245.124681483348 13141.833894829959 15315.790942086314 0.9181345747199359 0.9562882363436372 0.7025687063916094 0.7300916482854138 0.6048139898373736 0.8769977512693713 0.843285502073632 0.8648018722354733 0.858057800901256 1.0 13.90273225244524 -8.592521570919292 0.8106328391145236 0.9962095112028639 0.7946939837236099 0.25831348843832336 0.09955342874168942 1.1314011174170033 1.635761629342196 0.10632999394890798 0.03847493447464387 2.5555149683527066e-09 8.592521570919292 -0.20151552747925405 SLS(ph)PGAASSSSGDGDGKEGLEEPK ddPTM_A459_Selumetinib_30min_R2 3 SLSPGAASSSSGDGDGKEGLEEPK 24 1 Q6ZN18-2;Q6ZN18 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.033)LS(0.904)PGAAS(0.041)S(0.008)S(0.002)S(0.012)GDGDGKEGLEEPK;S(0.05)LS(0.95)PGAASSSSGDGDGKEGLEEPK;S(0.062)LS(0.914)PGAAS(0.006)S(0.006)S(0.002)S(0.009)GDGDGKEGLEEPK 115.34 8.3129e-08 84198100.0 187572.0 167518.0 180208.0 174193.0 152705.0 136796.0 174167.0 165284.5 108776.7 154277.0 True False 177147.49915020898 180366.09194473294 168613.6134756352 150467.61290031442 133520.83269997902 155638.40728955055 182266.11060536333 165765.45053067818 130535.0794749404 149822.622150215 1.1823815162746087 1.2038642052592998 1.1254215889145232 1.0043050291127114 0.891192737009425 1.0388178037192843 1.2165459927848536 1.1064113559865385 0.8712641495759129 1.0 17.192895951369913 -5.57084112606723 3.691099882068242 1.027019597513499 1.1896334715622936 0.36953496625765425 0.09318165030002737 0.2724706942290944 7.693122983833159 0.028192132208853596 0.05436180963553459 2.6863269800804246e-06 5.57084112606723 0.16261387404879457 SLS(ph)PGGAALGYR ddPTM_A459_Selumetinib_30min_R1 1 SLSPGGAALGYR 12 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 S(0.355)LS(0.645)PGGAALGYR 163.45 0.00050089 191460000.0 2365.0 2627.5 2831.3 3015.0 2377.0 2225.2 2467.1 2867.2 1511.8 2062.7 True False 2420.0998985110787 2319.87107850839 2446.8250112176597 2488.486848559424 2162.000769693436 2202.816508319947 2281.0046607263953 2791.1525420218345 2565.414182496707 2327.4676373994494 1.0397995914629043 0.9967361269523183 1.0512820766657671 1.0691821482595936 0.9289069093605552 0.9464434533582693 0.9800371116115846 1.199222922446507 1.102234093945608 1.0 11.184545392429863 -7.738341688044206 24.99606866785366 1.1130464353084983 1.001142785650603 0.3468743210976395 0.06134767647190371 223.73097714100155 242119.58698824997 0.029548400354782817 0.01704648162539419 1.8266624950681616e-08 7.738341688044206 -0.11190364965789534 SLS(ph)PGVSR ddPTM_A459_Selumetinib_30min_R2 4 SLSPGVSR 8 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 S(0.183)LS(0.817)PGVSR;S(0.417)LS(0.583)PGVSR;S(0.076)LS(0.924)PGVSR;S(0.004)LS(0.996)PGVSR 125.71 0.0050199 228810000.0 892620.0 729000.0 1007390.0 1007570.0 1106380.0 829640.0 833000.0 834890.0 754690.0 879410.0 True False 843011.7538409752 784911.9558955485 942575.6241633024 870337.2278448006 967386.6532373058 943915.3792779242 871736.1505581865 837319.3916765196 905649.0878004481 854019.1483184159 0.9871110682949973 0.9190800433937095 1.1036937825331625 1.0191073930350572 1.1327458583828165 1.1052625472584732 1.020745439109481 0.9804456882790293 1.0604552480862903 1.0 19.703908891910586 -5.256194885425216 24.999943363957257 1.0544883858469143 0.953095552054409 0.3951533823972999 0.049310083535496825 439.8442777118661 2096672.2150376977 0.013140893409343862 0.03271890630124691 5.543768858965249e-06 5.256194885425216 -0.1013928337925053 SLS(ph)PIIGK ddPTM_A459_Selumetinib_30min_R1 1 SLSPIIGK 8 0 Q9H4G0-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0;Q9H4G0-4;H7C2K6;X6RC15 Q9H4G0-3 EPB41L1 Band 4.1-like protein 1 1 S(0.382)LS(0.618)PIIGK 109.29 0.012513 594720000.0 10320.0 12548.0 12037.0 12192.0 11904.0 9837.6 13026.0 11314.0 6266.5 9959.2 True False 10560.43592077561 11078.874326593057 10402.441514508171 10062.896072184569 10827.285301821896 9738.642675826137 12043.438332707236 11013.915966948605 10633.792812948554 11237.560330823007 0.9397445361703516 0.9858789630882161 0.9256850426845562 0.895469815150491 0.9634907384767682 0.8666153852909199 1.0717128965860874 0.9800984949321271 0.946272366946195 1.0 13.456041240672533 -7.256888749870055 24.999350691221974 0.9978624794487008 0.9318717302263374 0.39403917256813226 0.0424686312922914 446.0583491882001 2450474.5107596456 0.016682387995226162 0.012479743260577733 5.534918751361495e-08 7.256888749870055 -0.06599074922236337 SLS(ph)PILPGR ddPTM_A459_Selumetinib_30min_R1 1 SLSPILPGR 9 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 S(0.163)LS(0.837)PILPGR 103.26 0.015402 78907000.0 4003.8 4967.5 4619.5 5341.5 4176.0 3823.5 3978.9 3744.7 2869.9 3446.6 True False 4097.0807499613775 4385.902790671906 3992.197273097155 4408.707297373189 3798.281537332683 3785.0390614602334 3678.768369569232 3645.378391500128 4870.01069079726 3889.004682726984 1.053503681329715 1.1277699947629003 1.0265344474457696 1.1336338361726497 0.9766718857919489 0.9732667790994148 0.9459408434010078 0.9373551046855454 1.2522511768698597 1.0 11.925185256575615 -6.270775118963994 24.818149368686782 1.0056510042331055 1.0841878810876435 0.12807413466578077 0.08920285038601775 1186.7682350200357 3154899.2528612628 0.027296814098397158 0.03134523037142022 5.36074169002193e-07 6.270775118963994 0.07853687685453803 SLS(ph)PILPGR ddPTM_A459_Selumetinib_30min_R2 1 SLSPILPGR 9 0 M0QZS0;A0A590UK10;A0A3B3IPE9;A0A087WZG4;Q6ZSZ5-2;Q6ZSZ5-1;Q6ZSZ5-6;Q6ZSZ5-5;Q6ZSZ5 M0QZS0 ARHGEF18 Rho guanine nucleotide exchange factor 18 1 S(0.001)LS(0.999)PILPGR 109.83 0.011204 44839000.0 36407.0 30092.0 36298.0 37799.0 38077.0 20571.0 26608.0 26208.0 21208.0 24130.0 True False 34383.64468876835 32399.959638969533 33962.626198274236 32650.71099308802 33293.426847301016 23404.46852505445 27845.324722751757 26284.260941032033 25450.19260103073 23433.304202730727 1.4672981834444652 1.3826458001255284 1.4493315114441483 1.3933464402038178 1.4207738933983227 0.9987694574599122 1.1882799148532748 1.1216626009561672 1.0860693131814065 1.0 14.516272774672247 -6.7511411946494695 24.9996713364979 1.093392900955055 1.420306254549852 0.8999200967767463 0.057208645389992076 60.82348376481306 147653.7059260807 0.018247272639410415 0.018052680011409725 1.7736127631206668e-07 6.7511411946494695 0.326913353594797 SLS(ph)PNHNTLQTLK ddPTM_A459_Selumetinib_30min_R2 2 SLSPNHNTLQTLK 13 0 A0A499FJI4;O75592-2;O75592 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 S(0.045)LS(0.955)PNHNTLQTLK;SLS(0.998)PNHNT(0.002)LQTLK 151.22 0.00047135 18679800.0 51083.0 48092.0 53703.0 67764.0 72566.0 49504.0 43947.0 50443.0 44644.0 48432.0 True False 48244.01136145117 51780.50175984725 50247.80744740538 58534.42630057983 63449.61033172901 56322.726647430616 45990.62257932846 50589.78077871182 53574.04745758279 47033.64231855178 1.025734112504019 1.1009247680446628 1.0683375764752503 1.244522503788564 1.3490260843928343 1.1974987237000543 0.977823964128504 1.0756084003887016 1.139058019252131 1.0 15.521405439396647 -10.310527544076804 5.185835629317472 0.9999999309098968 1.133804249385086 0.1250903381818289 0.10364664227498908 79883785.62782437 6.325398126646775 65.92267561253902 0.028000991001547765 4.891842388237052e-11 10.310527544076804 0.13380431847518914 SLS(ph)PPQSQSK ddPTM_A459_Selumetinib_30min_R2 2 SLSPPQSQSK 10 0 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6;I3L0Y9 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 SLS(0.997)PPQS(0.003)QSK;SLS(1)PPQSQSK 120.55 0.0050533 115967000.0 74320.0 73271.0 75562.0 78866.0 82642.0 57890.0 68797.0 57124.0 49619.0 74495.0 True False 70189.59192653233 78890.65009660157 70700.42318568504 68124.31474856162 72259.77313114602 65863.82202690213 71996.19681866937 57290.221382612704 59544.1864706971 72344.13578874551 0.9702181270296084 1.0904912918853955 0.9772792558078193 0.9416701714081384 0.9988338701308723 0.9104237863761789 0.9951905020872436 0.7919124440149201 0.8230685987399731 1.0 16.142588456273543 -6.942571235280906 0.9188801896086547 0.8723562659670329 1.009773503074722 0.2961272543316137 0.07047183519395121 0.6379863220000431 1.1312717901366478 0.04672693916774535 0.03591686502655219 1.1413760747156463e-07 6.942571235280906 0.13741723710768905 SLS(ph)PQDEQCAVEEALDWR ddPTM_A459_Selumetinib_30min_R1 2 SLSPQDEQCAVEEALDWR 18 0 A0A0A0MTR7;A0A0A0MTC1;Q63HN8;Q63HN8-4 A0A0A0MTR7 RNF213 E3 ubiquitin-protein ligase RNF213 1 S(0.019)LS(0.981)PQDEQCAVEEALDWR;S(0.012)LS(0.988)PQDEQCAVEEALDWR 207.56 1.747e-11 3813100.0 673.48 798.7 840.7 684.5699999999999 905.48 768.96 541.79 553.45 241.872 470.01 True False 689.1707736360428 705.1878326944434 726.5375576345452 565.0227004704225 823.5794938754786 761.2249605598175 500.92234410236875 538.7707081410379 410.4391183680671 530.3403617850954 1.299487693745076 1.3296891647485047 1.3699458121366839 1.0653963778441986 1.5529262964322705 1.4353517390182744 0.9445299286976626 1.0158961055265836 0.7739164279078297 1.0 9.050774739368492 -7.270975241694577 24.20366521063545 0.9349102307243335 1.3398340401848265 0.7029122473086151 0.13011240686892842 256.8937126223577 652037.1631744602 0.05468019622199519 0.0374333994934769 5.358272031361145e-08 7.270975241694577 0.404923809460493 SLS(ph)PQDR ddPTM_A459_Selumetinib_30min_R2 1 SLSPQDR 7 0 E9PKP7;P17480-2;P17480 E9PKP7 UBTF Nucleolar transcription factor 1 1 S(0.121)LS(0.879)PQDR 92.239 0.027284 18923000.0 61536.0 58909.0 62337.0 81769.0 71614.0 52480.0 55328.0 61695.0 41896.0 67281.0 True False 58116.075468125615 63427.13087771028 58326.30528739382 70631.92114060713 62617.209082716996 59708.64363399237 57900.86163035211 61874.52223584291 50276.370672047495 65338.42271296835 0.8894624794269904 0.9707478118402953 0.8926800321400663 1.0810166240298318 0.9583520152880696 0.9138366240686954 0.8861686466584993 0.9469852449248377 0.7694763446144325 1.0 15.99564400770093 -6.838803023393788 3.9807457543809996 0.896935857842378 0.9624243844412309 0.12362080611556081 0.07337747052460966 0.44117051364785326 13.506774479948085 0.025941931782904586 0.0231318138892202 1.4494291008759212e-07 6.838803023393788 0.06548852659885296 SLS(ph)PQEDALTGSR ddPTM_A459_Selumetinib_30min_R2 2 SLSPQEDALTGSR 13 0 Q96EN8 Q96EN8 MOCOS Molybdenum cofactor sulfurase 1 S(0.006)LS(0.994)PQEDALTGSR;SLS(1)PQEDALTGSR 166.52 0.00032988 19264100.0 67091.0 52653.0 59067.0 76311.0 67675.0 42160.0 52074.0 52921.0 49826.0 53327.0 True False 63362.350806552524 56691.31579392078 55266.69352728704 65917.31015618231 59173.06147782372 47967.15730962501 54495.54418267346 53074.991348456846 59792.5922547603 51787.310949814404 1.2235111197017965 1.0946951049236502 1.067186005870133 1.2728467446409968 1.1426169923201195 0.9262337902832724 1.0522953052241606 1.0248647858910902 1.1545799764097344 1.0 15.660311028188389 -6.5588468056723 22.4248361941555 1.0344402939855035 1.159503853197003 0.42001742030586775 0.07576616419320463 61.643108546966346 38431.35041311463 0.025200537464713117 0.025200760698929202 2.761551802433119e-07 6.5588468056723 0.12506355921149948 SLS(ph)PQLLQQMPSKPEGAAK ddPTM_A459_Selumetinib_30min_R1 2 SLSPQLLQQMPSKPEGAAK 19 1 Q9UPX8;Q9UPX8-3;A0A2R8Y2H5;A0A087X158 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 S(0.175)LS(0.825)PQLLQQMPSKPEGAAK;S(0.163)LS(0.837)PQLLQQMPSKPEGAAK 144.63 3.215e-05 108831000.0 6405.8 6413.1 8108.6 7920.5 7435.299999999999 6276.3 6684.700000000001 6434.1 3856.4 5369.0 True False 6555.0426764829845 5662.251270630694 7007.496657351577 6537.333361198974 6762.778427808835 6213.166120424445 6180.467697117151 6263.446767097754 6544.0291396879875 6058.163448488703 1.0820181284673387 0.9346481518327515 1.1567031356837523 1.0790949132991463 1.1163083474573319 1.025585752720886 1.0201883375495522 1.0338854044389083 1.0802001621994024 1.0 12.564664787051406 -6.84956419428924 24.974791495621183 1.0333528196833701 1.0709561626544282 0.11976466315828738 0.056319574839249466 55.82560491579831 15808.516233550301 0.0201801413248781 0.01779721322580841 1.4139557088514652e-07 6.84956419428924 0.03760334297105805 SLS(ph)PQLLQQMPSKPEGAAK ddPTM_A459_Selumetinib_30min_R2 4 SLSPQLLQQMPSKPEGAAK 19 1 Q9UPX8;Q9UPX8-3;A0A2R8Y2H5;A0A087X158 Q9UPX8 SHANK2 SH3 and multiple ankyrin repeat domains protein 2 1 S(0.084)LS(0.916)PQLLQQMPSKPEGAAK;S(0.192)LS(0.808)PQLLQQMPSKPEGAAK;S(0.045)LS(0.955)PQLLQQMPSKPEGAAK;S(0.033)LS(0.967)PQLLQQMPSKPEGAAK 154.66 3.3269e-06 98349300.0 337693.0 297854.0 314388.0 334451.0 306329.0 245348.0 313392.0 293019.0 231314.0 299726.0 True False 318925.3749521867 320698.44404843927 294160.6183597724 288898.1968398441 267845.2124039935 279142.4599526061 327965.34897446714 293871.63677809347 277583.2634531691 291072.1315983289 1.0956918932805786 1.1017834042971653 1.0106107264356916 0.9925312851266547 0.9202021881421891 0.9590147240128596 1.1267493977302157 1.0096179086757362 0.9536579882412994 1.0 18.151017191157713 -5.30498137612782 4.1353731555263105 0.9963221580656582 1.1002080706905644 0.39055734754874294 0.05128277677612467 0.22794391476109938 8.54000508897393 0.01480587060225229 0.03526326342981663 4.954714376758825e-06 5.30498137612782 0.10388591262490621 SLS(ph)PSHLTEDR ddPTM_A459_Selumetinib_30min_R1 4 SLSPSHLTEDR 11 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 S(0.227)LS(0.681)PS(0.092)HLTEDR;S(0.174)LS(0.825)PS(0.001)HLTEDR;S(0.038)LS(0.64)PS(0.004)HLT(0.317)EDR;S(0.002)LS(0.993)PS(0.001)HLT(0.004)EDR 168.83 0.00045652 205479000.0 16750.5 17960.899999999998 19354.7 21084.7 21633.100000000002 16748.0 20598.5 16325.9 7109.0 12297.2 True False 17140.754059200764 15858.029478204116 16726.438047757012 17402.65295383777 19676.389924634026 16579.53032596732 19044.738561052505 15892.88409800302 12063.453779183159 13875.665404871535 1.2353104200093283 1.142866234914875 1.2054512385319276 1.2541851108436184 1.418050187180641 1.1948638023619753 1.37252794769512 1.1453781591204462 0.8693964164736823 1.0 13.760269336834913 -8.07619848492158 4.4506682982284955 0.9422989116302374 1.2576524189463631 0.7064723763385365 0.08296055943330105 0.12493843134636763 4.497267051416486 0.061047967627121176 0.02207413521928902 8.390764171044888e-09 8.07619848492158 0.31535350731612577 SLS(ph)PSHLTEDR ddPTM_A459_Selumetinib_30min_R2 6 SLSPSHLTEDR 11 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 S(0.011)LS(0.988)PS(0.002)HLTEDR;S(0.049)LS(0.916)PS(0.036)HLTEDR;S(0.159)LS(0.813)PS(0.028)HLTEDR;S(0.001)LS(0.802)PS(0.079)HLT(0.118)EDR;S(0.057)LS(0.942)PS(0.001)HLTEDR;S(0.003)LS(0.95)PS(0.047)HLTEDR 154.67 0.00053883 285563200.0 175076.0 155531.0 191253.0 215024.0 238297.0 162661.0 142424.0 152954.0 140584.0 195397.0 True False 165345.97680475743 167459.727589013 178947.99020052215 185737.3602629104 208360.00045779048 185066.07626045813 149046.99820780216 153399.0708171023 168704.7282451578 189755.3809076239 0.8713638370300055 0.882503182718888 0.9430456693485653 0.9788252611046137 1.0980452805141985 0.975287632821076 0.785469152415555 0.8084043260505984 0.8890642649405873 1.0 17.53378127126952 -7.240937536528818 24.382092804404863 0.854768125246584 0.9613469171975854 0.21501697367674133 0.07940716689336827 811.4249404084861 964999.0906441745 0.03231051970361555 0.0249950417440196 5.741990418569209e-08 7.240937536528818 0.1065787919510014 SLS(ph)PSPLGSSAASTALER ddPTM_A459_Selumetinib_30min_R2 1 SLSPSPLGSSAASTALER 18 0 A0A0C3SFZ9;M0QZI3;O14526-3;O14526-2;O14526 A0A0C3SFZ9 FCHO1 F-BAR domain only protein 1 1 S(0.002)LS(0.709)PS(0.141)PLGS(0.083)S(0.022)AAS(0.038)T(0.004)ALER 85.176 0.007733499999999998 3870700.0 23787.0 17591.0 23268.0 23942.0 21424.0 19552.0 23323.0 24219.0 15256.0 17167.0 True False 22465.013766905617 18940.17313601997 21770.962212282902 20681.058297746316 18732.52558700993 22245.11052461547 24407.565713647735 24289.4732803287 18307.626288255586 16671.344104777392 1.3475226487867868 1.1360915482868843 1.3058912392099296 1.2405153518377614 1.1236361908960826 1.3343321561121662 1.4640430645693066 1.4569595065444203 1.098149385748045 1.0 14.02508280391725 SLS(ph)PSSNSAFSR ddPTM_A459_Selumetinib_30min_R1 2 SLSPSSNSAFSR 12 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 S(0.001)LS(0.999)PSSNSAFSR;S(0.019)LS(0.981)PSSNSAFSR 206.46 1.0308e-05 66379000.0 4431.9 4699.6 4854.799999999999 5751.6 5231.700000000001 4671.200000000001 4221.5 4429.4 2556.3999999999996 3751.3 True False 4535.154647023785 4149.368647215237 4195.544825507538 4747.191030903607 4758.493658731657 4624.211969110253 3903.068856250853 4311.917923281081 4338.02408793133 4232.815895756322 1.0714273331780335 0.9802856418525676 0.9911947339155123 1.1215207908435092 1.1241910293103845 1.0924670675486576 0.9220974765672983 1.0186878025108685 1.024855366915553 1.0 12.047402025372405 -10.387356115270986 6.342791137427833 0.9999999976180645 1.0379595961904726 0.03389627790448535 0.06163592956656639 2.2375056370006113e-09 4.5803510192917993e-10 0.06498868969141723 0.015762071535107454 4.0986787935031425e-11 10.387356115270986 0.03795959857240816 SLS(ph)PSVR ddPTM_A459_Selumetinib_30min_R2 1 SLSPSVR 7 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 S(0.004)LS(0.994)PS(0.002)VR 95.815 0.023547 17754000.0 28272.0 24358.0 38290.0 38638.0 35722.0 26278.0 31472.0 31325.0 25766.0 38669.0 True False 26700.75542178312 26226.180276685507 35826.46308699984 33375.437745732306 31234.28300126813 29897.555972066526 32935.510360584914 31416.150563867086 30919.919962191518 37552.525495872134 0.7110242272445333 0.6983865913244198 0.954036049877337 0.8887667954423203 0.8317491989906639 0.7961530037534477 0.8770518074531436 0.8365922171418385 0.8233779101112736 1.0 15.196622315194459 -14.522874051587655 0.022814504700865355 2.0926970557507363 5.853222835111969e-11 0.3945973838497281 0.0701536309976207 3121.4433597314187 5.364087391679463 345.9210220445749 173.4913053425387 3.0000324230556148e-15 14.522874051587655 -2.092697055692204 SLS(ph)PVAAPPLR ddPTM_A459_Selumetinib_30min_R2 1 SLSPVAAPPLR 11 0 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 S(0.037)LS(0.963)PVAAPPLR 88.155 0.031044 5200000.0 30638.0 21302.0 28072.0 28085.0 33336.0 30725.0 32707.0 33140.0 28695.0 28809.0 True False 28935.262613631552 22935.794903274254 26265.878082482635 24259.774550672686 29148.033652378756 34957.089856219834 34227.940307690966 33236.43191337765 34434.80180528937 27977.209315228727 1.034244062286846 0.8198028132416231 0.9388312389036397 0.8671263197601148 1.0418492181960664 1.2494845165701276 1.2234222478029573 1.1879823873386182 1.2308161767423174 1.0 14.771964442557026 -6.5344313232609315 3.870044601349083 1.1918731462440537 0.9119096551030118 0.6870104060685995 0.0834196256513888 0.1125083584463999 3.7752949383038503 0.026275281192983516 0.027592157218602656 2.921249672683924e-07 6.5344313232609315 -0.2799634911410419 SLS(ph)PVAAPPLREPR ddPTM_A459_Selumetinib_30min_R1 4 SLSPVAAPPLREPR 14 1 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 S(0.047)LS(0.953)PVAAPPLREPR;S(0.057)LS(0.943)PVAAPPLREPR;S(0.003)LS(0.997)PVAAPPLREPR;S(0.012)LS(0.988)PVAAPPLREPR 102.63 0.012981 145936000.0 13768.900000000001 15670.9 18994.0 19509.2 17778.4 16646.0 16422.100000000002 15970.500000000002 10051.0 14508.199999999999 True False 14089.68858038444 13836.143742796234 16414.719126573735 16102.284453039962 16170.346859031451 16478.556353358726 15183.367775491439 15546.91046050492 17055.81290400477 16370.468791835314 0.8606771595576785 0.845189219608478 1.0027030584952148 0.9836177972539731 0.9877754305421191 1.0066025941527905 0.9274852155158846 0.9496924405890478 1.041864660131863 1.0 13.99880801559317 -5.258551850634867 24.996530479249614 0.9840856110613383 0.8529331757945098 0.7630241692064346 0.029942576341708854 115.17611301552316 997034.7373166489 0.007855732529026629 0.018981734713939276 5.5137636935208e-06 5.258551850634867 -0.13115243526682852 SLS(ph)PVAAPPLREPR ddPTM_A459_Selumetinib_30min_R2 1 SLSPVAAPPLREPR 14 1 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 S(0.303)LS(0.697)PVAAPPLREPR 65.105 0.040143 35153000.0 77898.0 72945.0 82668.0 82061.0 91998.0 51824.0 66000.0 70716.0 53591.0 83347.0 True False 73568.74101040115 78539.6469448567 77349.23088211277 70884.15023687902 80440.3887674448 58962.28558856746 69069.1307765189 70921.77185233598 64310.69745764986 80940.55554848733 0.9089231042691558 0.970337384178289 0.95563009616084 0.8757556673108818 0.993820566492864 0.7284640584564085 0.8533315630029636 0.8762204728116845 0.7945423282784935 1.0 16.304575130759616 -6.73602111747173 24.99998776205707 0.8429515889527094 0.9397290772681569 0.28505439485036754 0.07105411809727295 270.2256552695314 265778.3010484525 0.022138874120361692 0.022131169473270262 1.8364490442545983e-07 6.73602111747173 0.09677748831544752 SLS(ph)QGSTNATVLDVAQTGGHK ddPTM_A459_Selumetinib_30min_R2 1 SLSQGSTNATVLDVAQTGGHK 21 0 A0A2R8Y661;H0Y8T6 A0A2R8Y661 RAPGEF2 1 S(0.157)LS(0.563)QGS(0.258)T(0.021)NAT(0.001)VLDVAQTGGHK 123.76 4.7431e-05 7170400.0 69975.0 64137.0 60972.0 67858.0 68259.0 49770.0 63822.0 67269.0 53195.0 58164.0 True False 66086.06963211928 69056.10166704073 57049.127901294196 58615.62333842079 59683.69417679752 56625.36573292304 66789.84946089386 67464.74165301758 63835.48639248533 56484.65419177906 1.16998272500246 1.222563945112925 1.0099933994036436 1.0377265148761745 1.0566355593531112 1.0024911463681132 1.1824423892926064 1.1943906290717206 1.1301385713675154 1.0 15.785571347456688 -11.183626198308579 13.972259311729877 0.9999980067478944 1.1095687712653854 0.1603407670855973 0.07660958864450719 5.231722049764476e-06 1.2707625725766223e-07 0.0815833389367983 0.019786506174280825 6.551998686551981e-12 11.183626198308579 0.10957076451749104 SLS(ph)SPGGPSKPK ddPTM_A459_Selumetinib_30min_R1 1 SLSSPGGPSKPK 12 1 J3KRY8;Q9BZE9-3;Q9BZE9;Q9BZE9-2;J3QR12;Q9BZE9-4;J3QL04 J3KRY8;J3QL04 ASPSCR1 Tether containing UBX domain for GLUT4 1 S(0.001)LS(0.5)S(0.5)PGGPSKPK 170.66 0.0014128 46106000.0 6465.4 7552.4 7825.5 7742.8 6683.8 6039.7 6613.9 6962.7 4028.5 5468.1 True False 6616.031240521578 6668.161496984491 6762.840082394585 6390.665330356848 6079.251470120734 5978.946101608833 6115.008198118558 6778.026577962967 6836.070270001312 6169.983898804448 1.0722931127589426 1.0807421228889391 1.0960871524648572 1.0357669379972227 0.9852945436857145 0.9690375533666089 0.9910898145623132 1.0985485033885323 1.1079559334548557 1.0 12.591051009183412 -5.853218442120058 5.539012866788289 1.0245506319898594 1.082575282745988 0.25940330106980536 0.04370981367927744 0.3206408606240592 15.319512659813714 0.014118395530534315 0.021368402702721168 1.4021082925428576e-06 5.853218442120058 0.058024650756128615 SLS(ph)SPGGPSKPK ddPTM_A459_Selumetinib_30min_R2 1 SLSSPGGPSKPK 12 1 J3KRY8;Q9BZE9-3;Q9BZE9;Q9BZE9-2;J3QR12;Q9BZE9-4;J3QL04 J3KRY8;J3QL04 ASPSCR1 Tether containing UBX domain for GLUT4 1 S(0.001)LS(0.5)S(0.5)PGGPSKPK 92.112 0.012162 103340000.0 255160.0 216600.0 257240.0 255950.0 230080.0 182850.0 221240.0 223190.0 144340.0 238240.0 True False 240979.2286864102 233212.52352122805 240689.45846173476 221089.16846162232 201175.2934587026 208035.92775296335 231528.09837874325 223839.44594890627 173212.03319656634 231361.39217814224 1.0415706199626533 1.0080010382270717 1.0403181628350946 0.9556009599535493 0.8695283667026125 0.8991816905768838 1.0007205445948935 0.9674883256950483 0.7486643798512311 1.0 17.819788613038597 -5.912980192403845 4.16772110701677 0.9158101763471574 1.0272249762077663 0.3555831202096036 0.06943448452189407 0.2523615525764219 8.226058734772518 0.020010831164401353 0.030493118205420312 1.221855386100046e-06 5.912980192403845 0.11141479986060887 SLS(ph)SPPSSK ddPTM_A459_Selumetinib_30min_R1 2 SLSSPPSSK 9 0 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 S(0.012)LS(0.494)S(0.494)PPS(0.001)SK;SLS(0.497)S(0.497)PPS(0.005)SK 115.7 0.0080838 65020000.0 8956.099999999999 10883.900000000001 11637.6 11830.7 10254.0 9485.2 10537.5 9001.099999999999 5447.0 8038.2 True False 9164.75970446303 9609.607928212166 10057.277840761008 9764.6903347436 9326.527510490743 9389.787499872537 9742.647891210074 8762.361588306616 9243.161166860415 9069.981268698435 1.0104496837376815 1.05949589569452 1.1088532095948036 1.076594322023871 1.0282852008391328 1.0352598557483013 1.074164058621939 0.966083757917621 1.0190937437500167 1.0 13.146883855968941 -7.755050112324852 24.999200763093544 0.9944415602407829 1.0572228939867065 0.48593734593274673 0.028780908630529112 129.29963468696735 505914.5637880669 0.014673281233299763 0.00820292774332933 1.7577207825606328e-08 7.755050112324852 0.06278133374592365 SLS(ph)SPPSSK ddPTM_A459_Selumetinib_30min_R2 1 SLSSPPSSK 9 0 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 S(0.207)LS(0.389)S(0.389)PPS(0.015)S(0.001)K 115.57 0.0081236 12165000.0 139320.0 103100.0 143340.0 145280.0 186980.0 72172.0 92144.0 129750.0 91271.0 82991.0 True False 131577.1521421487 111007.43848124948 134117.66045679164 125492.61337802101 163489.90077759136 82113.03788781441 96428.87857987203 130127.55101873125 109527.75032481481 80594.83419348625 1.6325755051033144 1.3773517818121053 1.664097479682279 1.5570801110744568 2.0285406926341785 1.0188374814530092 1.1964647554007315 1.6145892267279864 1.3589921912596594 1.0 16.298399750284354 -6.775962248188248 24.999998209804257 1.2736066307933442 1.6320815422407298 0.4577638770544453 0.22315841477341178 264.89352703660455 455990.9772273945 0.08084148260994557 0.07160426757852349 1.6750884797104513e-07 6.775962248188248 0.3584749114473855 SLS(ph)SPTDNLELSLR ddPTM_A459_Selumetinib_30min_R1 1 SLSSPTDNLELSLR 14 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 S(0.126)LS(0.806)S(0.068)PTDNLELSLR 265.43 1.5279e-36 82100000.0 2487.6 2775.8 2999.8 2892.9 3216.0 2188.9 2775.2 2429.3 1415.2 1798.6 True False 2545.5562399730065 2450.808045565591 2592.4436367219073 2387.709321458559 2925.113367830915 2166.8816533621825 2565.864429673662 2364.867072521499 2401.491037881559 2029.4678298476047 1.2542974086778973 1.2076111823608582 1.2774007050491543 1.1765199163752476 1.4413203918835047 1.0677092888557373 1.2643040662863505 1.1652646263917767 1.1833107194716608 1.0 10.986885755967872 -9.153274655227069 0.47426076876940243 0.9820725224689955 1.252726383807079 0.4006740700054703 0.08852642118987708 2.4242001021258477 0.9090695379954168 0.17527109321487877 0.0469799351507761 7.026278255420303e-10 9.153274655227069 0.27065386133808356 SLS(ph)SPTVTLSAPLEGAK ddPTM_A459_Selumetinib_30min_R1 2 SLSSPTVTLSAPLEGAK 17 0 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5;Q96PU5-2;Q96PU5-9;Q96PU5-6;Q96PU5-5 A0A1B0GVY1;Q96PU5-9 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 S(0.002)LS(0.499)S(0.499)PTVTLSAPLEGAK;S(0.099)LS(0.442)S(0.442)PT(0.018)VTLSAPLEGAK 321.02 1.2467999999999994e-118 622140000.0 12458.8 12517.5 15214.5 13220.6 13268.8 10666.5 11166.5 12353.9 6465.3 9944.1 True False 12749.065799395272 11051.94528077212 13148.454467266303 10911.870391397906 12068.639382796913 10559.20469440711 10324.201914799276 12026.234440877344 10971.141893171027 11220.522098736552 1.136227502357563 0.9849760272756458 1.1718219840008015 0.9724922151908243 1.075586258517851 0.9410617974359761 0.9201177827511072 1.0718070277880845 0.9777746344268948 1.0 13.453852186666714 -5.790742805481255 24.99311818835122 0.995212146951976 1.0864053814440657 0.3461222813400915 0.06465876917009752 244.44711156366282 208489.8931514679 0.01776246586618781 0.026350482426256743 1.6190385682856742e-06 5.790742805481255 0.09119323449208971 SLS(ph)SPTVTLSAPLEGAK ddPTM_A459_Selumetinib_30min_R2 3 SLSSPTVTLSAPLEGAK 17 0 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5;Q96PU5-2;Q96PU5-9;Q96PU5-6;Q96PU5-5 A0A1B0GVY1;Q96PU5-9 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 S(0.149)LS(0.656)S(0.195)PTVTLSAPLEGAK;S(0.073)LS(0.865)S(0.042)PT(0.019)VTLSAPLEGAK;S(0.106)LS(0.411)S(0.411)PT(0.054)VT(0.006)LS(0.012)APLEGAK 184.92 5.9589e-08 308169000.0 607411.0 455446.0 565987.0 588832.0 476552.0 473286.0 634118.0 529191.0 453280.0 418623.0 True False 573653.5282788875 490377.2437102926 529572.0126200528 508632.06580814207 416683.27733106574 538476.850437457 663605.7434809793 530730.8581977143 543948.6657013956 406536.2662768232 1.4110759011307221 1.2062324677729477 1.302643962050487 1.2511357731164843 1.0249596700121537 1.3245481279419027 1.6323408230180123 1.3054944963663417 1.3380077272884778 1.0 18.63302453238022 -6.985534162902976 24.979595426500584 1.3635652302133443 1.2348831721560891 0.0279695442727963 0.17006871582886476 529.1117171227918 913665.7134198833 0.05855522001709802 0.051621956462003765 1.033869770494982e-07 6.985534162902976 -0.1286820580572552 SLS(ph)TSGESLYHVLGLDK ddPTM_A459_Selumetinib_30min_R1 2 SLSTSGESLYHVLGLDK 17 0 Q9H3Z4-2;Q9H3Z4 Q9H3Z4-2 DNAJC5 DnaJ homolog subfamily C member 5 1 S(0.007)LS(0.95)T(0.033)S(0.008)GES(0.002)LYHVLGLDK;S(0.181)LS(0.787)T(0.031)S(0.001)GESLYHVLGLDK 159.72 1.9624e-05 273430000.0 11503.5 7028.2 8454.5 6277.6 13593.0 8611.0 11981.7 13428.0 2382.75 6708.9 True False 11771.509168085498 6205.335076678464 7306.425337244271 5181.335005146477 12363.51555003907 8524.381158162438 11077.910722477984 13071.845819708833 4043.3527208255264 7570.052665219946 1.5550102078112134 0.8197215199292368 0.965174967779697 0.6844516457529737 1.6332139414091977 1.1260662950638487 1.46338621570952 1.7267839997687828 0.5341247808489384 1.0 12.886087621806693 -6.256795923117288 24.874984397603658 1.2883481058126607 0.9898551343549292 0.08072330657726556 0.38240762115717514 811.7822668298807 4348710.424077884 0.1106588836702385 0.13812762327679007 5.536101919623603e-07 6.256795923117288 -0.29849297145773146 SLS(ph)TSGESLYHVLGLDK ddPTM_A459_Selumetinib_30min_R2 2 SLSTSGESLYHVLGLDK 17 0 Q9H3Z4-2;Q9H3Z4 Q9H3Z4-2 DNAJC5 DnaJ homolog subfamily C member 5 1 S(0.02)LS(0.66)T(0.233)S(0.082)GES(0.006)LYHVLGLDK;S(0.001)LS(0.505)T(0.157)S(0.336)GESLYHVLGLDK 140.75 0.00050311 166968000.0 347843.0 126667.0 384986.0 487785.0 316654.0 277210.0 490706.0 401106.0 379211.0 380055.0 True False 328511.2785858558 136381.95160140118 360216.41990106436 421347.84152394056 276873.0935973224 315393.1612381674 513524.8013154921 402273.1520533266 455063.7960406205 369081.8246485212 0.890077095773272 0.3695168455701619 0.9759798392784597 1.1416109203567328 0.750167239638501 0.8545345237157591 1.3913575988319793 1.0899294551727485 1.232961814020456 1.0 18.493581168576632 -5.8529354401175375 0.5664470589725604 1.1623482153302802 0.5837013689587996 0.33540893777576086 0.21876064223364183 1.6141820987180806 0.869989220887172 0.15240977895866764 0.5373816216882424 1.4030222548048926e-06 5.8529354401175375 -0.5786468463714806 SLS(ph)VPDSGR ddPTM_A459_Selumetinib_30min_R1 2 SLSVPDSGR 9 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 S(0.149)LS(0.851)VPDSGR;S(0.047)LS(0.953)VPDSGR 112.85 0.0094578 28335000.0 4701.6 5299.1 5870.2 6023.3 6221.6 4358.1 4890.5 5669.9 2929.0 4284.3 True False 4811.138132278935 4678.678908515246 5073.059082700493 4971.443726344271 5658.8573785126955 4314.261470838198 4521.60564763586 5519.515833569193 4970.2990743040455 4834.231637615973 0.9952229212275754 0.9678226570919057 1.0494033929251885 1.028383432779809 1.1705805188316112 0.8924399561800473 0.9353307798601296 1.1417565907725455 1.0281466522268623 1.0 12.239070887768346 -5.259133489883149 24.640989175195752 1.0323791160195732 0.9815227884396301 0.05873438158113575 0.07862054978391042 523.7850889705953 5597079.932604597 0.020956914143477383 0.05025492615408849 5.506384196608232e-06 5.259133489883149 -0.05085632757994307 SLS(ph)VPDSGR ddPTM_A459_Selumetinib_30min_R2 4 SLSVPDSGR 9 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 S(0.002)LS(0.998)VPDSGR;S(0.002)LS(0.997)VPDS(0.001)GR;S(0.224)LS(0.776)VPDSGR;S(0.005)LS(0.995)VPDSGR 128.51 0.004305600000000001 69277000.0 461434.0 369863.0 548333.0 584506.0 604658.0 246767.0 415813.0 475090.0 305192.0 348612.0 True False 435789.3455466564 398230.3028030106 513053.8517598301 504895.27447090833 528695.4563288954 280756.9143222067 435149.1284178279 476472.433244617 366238.9277769608 338546.6657572474 1.2872356742072781 1.1762936784867317 1.5154597686326405 1.491360942343293 1.5616619798819489 0.8293004856338521 1.2853445992283044 1.4074054818376747 1.0817974737921947 1.0 18.368995185094683 -6.73227010362368 24.999925433092393 1.1565178266135383 1.4043971896240934 0.37655598089663234 0.18085392634391043 276.0359349025831 236579.6678356486 0.06258847732403364 0.06257938759118992 1.8523792027041938e-07 6.73227010362368 0.24787936301055513 SLS(ph)VPVDLSR ddPTM_A459_Selumetinib_30min_R1 4 SLSVPVDLSR 10 0 Q9NYF3;D6RHW3 Q9NYF3 FAM53C Protein FAM53C 1 S(0.117)LS(0.883)VPVDLSR;S(0.133)LS(0.867)VPVDLSR;S(0.469)LS(0.531)VPVDLSR;S(0.001)LS(0.999)VPVDLSR 172.21 0.00015105 131118000.0 13459.5 13032.0 14829.3 16121.900000000001 14582.2 12497.400000000001 12313.5 11845.0 7694.0 10211.6 True False 13773.080162372029 11506.207381587566 12815.562511514157 13306.512810544004 13263.242584696516 12371.687502731304 11384.682781344276 11530.832122017522 13056.156052473656 11522.358329407194 1.1953351708582587 0.9985982949533511 1.1122343313006042 1.1548428221142295 1.1510874948964451 1.0737114008298514 0.9880514436257771 1.0007354217225393 1.1331149126956004 1.0 13.492148408997222 -7.000130190491801 7.317712592166038 1.0304459846665668 1.1165042554076325 0.3355854802326085 0.06078744243225712 0.16234585166763196 59.03427666692114 0.022265471561603835 0.01872288925520655 9.9970027024227e-08 7.000130190491801 0.08605827074106576 SLS(ph)VPVDLSR ddPTM_A459_Selumetinib_30min_R2 3 SLSVPVDLSR 10 0 Q9NYF3;D6RHW3 Q9NYF3 FAM53C Protein FAM53C 1 SLS(1)VPVDLSR;S(0.012)LS(0.988)VPVDLSR;S(0.23)LS(0.769)VPVDLS(0.001)R 134.3 0.0021242 60144300.0 106478.0 95822.0 113459.0 119159.0 122770.0 103624.0 91635.0 100430.0 86194.0 99111.0 True False 100560.37902520609 103171.23928370817 106159.17146481891 102929.33863925938 107346.53502227447 117897.26539498536 95896.20907130776 100722.2346729185 103435.20846158243 96249.40790869632 1.0447895858289251 1.07191557356465 1.1029592157649755 1.0694023046552115 1.1152955364058454 1.2249141886340178 0.9963303791154372 1.046471213292711 1.0746581273487175 1.0 16.554490045337182 SLS(ph)YEEPR ddPTM_A459_Selumetinib_30min_R1 2 SLSYEEPR 8 0 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 SLS(1)YEEPR;S(0.001)LS(0.999)YEEPR 150.81 0.0012315 57941000.0 13508.9 14328.2 16011.1 16613.9 16677.699999999997 12971.400000000001 14282.1 13619.0 7663.9 10607.099999999999 True False 13823.631086256371 12650.647683000529 13836.880562676888 13712.594246527833 15169.204979687076 12840.919493088879 13204.789698415327 13257.7798792534 13005.078550890667 11968.624606903431 1.154989110301194 1.056984248273917 1.1560961277619033 1.1457117836763373 1.2674142165790352 1.0728817984384198 1.1032838051248497 1.10771122954315 1.0865975814288147 1.0 13.546969751813469 -8.605190303383235 0.7059920227961143 1.000783659787612 1.1430312870098978 0.3919425945371716 0.053358240553789356 0.931831669354698 1.0344127936401177 0.05554414778172109 0.021467213235378695 2.482045260220882e-09 8.605190303383235 0.14224762722228568 SLS(ph)YEEPR ddPTM_A459_Selumetinib_30min_R2 4 SLSYEEPR 8 0 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 S(0.004)LS(0.996)YEEPR;S(0.001)LS(0.996)Y(0.003)EEPR;S(0.016)LS(0.984)YEEPR;S(0.039)LS(0.957)Y(0.004)EEPR 154.85 0.0006596 118195000.0 558696.0 556322.0 648185.0 699021.0 817558.0 397221.0 506633.0 566235.0 451374.0 509430.0 True False 527645.9129572923 598990.1085428292 606481.4827904662 603813.1339215147 714849.0549787458 451934.58713677817 530192.4383742441 567882.65010475 541661.4124433077 494721.43224190164 1.0665515552180318 1.2107623998184573 1.2259050109111056 1.2205113717941192 1.4449526711210063 0.9135132575291337 1.07169894777269 1.147883663602985 1.0948816387207863 1.0 18.916256875488507 -6.776342178105682 24.99995780183285 1.0564697455433072 1.2312904911215437 0.4508122543015277 0.10346327761980303 252.36515780021588 423348.5774182688 0.03735362787412437 0.033074508878503356 1.6736237179869506e-07 6.776342178105682 0.17482074557823646 SLS(ph)YSPVER ddPTM_A459_Selumetinib_30min_R1 1 SLSYSPVER 9 0 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.001)LS(0.501)YS(0.498)PVER 136.52 0.0026332 31139000.0 3291.7 3360.3 3393.3 4096.0 3948.1 3027.4 3749.7 3048.4 1715.3 2912.8 True False 3368.390205466772 2966.8745138389104 2932.5084980626884 3380.710491442586 3590.9950520936704 2996.9471046592703 3466.857110099211 2967.546529401282 2910.738819444768 3286.686253074668 1.0248590665798023 0.9026947768632992 0.8922386477624236 1.02860760995363 1.0925883323162726 0.9118445978394351 1.0548183924936536 0.9028992428544607 0.8856150527668395 1.0 11.682418028048021 -10.740993819953225 4.319152138414341 1.0000138922773303 0.9668879046574762 0.01853140927729069 0.07356983483251027 1.0100483444921668e-05 1.8285331155030898e-06 0.07308376171177576 0.017717980288330774 1.8155414978965722e-11 10.740993819953225 -0.03312598761985408 SLSDNGQPGT(ph)PDPADSGGTSAK ddPTM_A459_Selumetinib_30min_R1 2 SLSDNGQPGTPDPADSGGTSAK 22 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 SLSDNGQPGT(1)PDPADSGGTSAK;SLSDNGQPGT(1)PDPADSGGTSAK 153.77 1.001e-07 27342000.0 9715.900000000001 13576.1 13285.6 14605.5 11710.4 11727.9 11216.5 10956.5 5488.0 8947.4 True False 9942.261566149598 11986.603900642342 11481.488492577026 12054.923604190593 10651.196387639036 11609.927974081209 10370.430374544047 10665.898028272262 9312.735172338893 10095.885945056401 0.9847834672714357 1.1872760811557859 1.1372442750503837 1.1940431646906098 1.0550036366897104 1.149966237461922 1.0271936936472703 1.0564598378307726 0.9224287222558225 1.0 13.301479896702936 -7.666219698357039 1.3366335332527863 0.9699065678216063 1.1243897865349586 0.4440135466849161 0.0650960420632032 0.39422630799516645 1.3120400480730123 0.049084083876334936 0.020390147234912788 2.156653138054349e-08 7.666219698357039 0.15448321871335224 SLSDNGQPGT(ph)PDPADSGGTSAK ddPTM_A459_Selumetinib_30min_R2 1 SLSDNGQPGTPDPADSGGTSAK 22 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 SLSDNGQPGT(0.905)PDPADS(0.094)GGT(0.001)SAK 264.54 5.0166999999999974e-117 0.0 84007.0 71569.0 91623.0 93284.0 98243.0 65661.0 72474.0 82485.0 64738.0 81060.0 True False 79338.2272466658 77058.11216939424 85728.07593157951 80578.55827612414 85900.83603643655 74705.20673878762 75844.18460450662 82725.01769387323 77687.40893085282 78719.58718082686 1.0078587818863667 0.9788937534997987 1.0890310658598024 1.0236151021857753 1.0912256925219086 0.9490040460601273 0.9634728448243111 1.0508822601399763 0.9868879107863838 1.0 16.264435034503336 -6.770709471542965 24.999751683387686 0.9915685308143779 1.0368562877284184 0.26145619308202805 0.040331512421046475 316.9594875543428 854775.4855736024 0.014607608296602575 0.0130623443813149 1.6954716348721217e-07 6.770709471542965 0.04528775691404052 SLSDNGQPGTPDPADS(ph)GGTSAK ddPTM_A459_Selumetinib_30min_R2 1 SLSDNGQPGTPDPADSGGTSAK 22 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 SLSDNGQPGT(0.041)PDPADS(0.958)GGT(0.001)SAK 254.54 5.944999999999997e-100 0.0 35631.0 30905.0 42713.0 37970.0 41946.0 27369.0 31311.0 35186.0 27973.0 32014.0 True False 33650.77166219423 33275.31412476253 39964.89208239814 32798.420498096544 36676.368478002165 31138.83131895461 32767.023541569466 35288.38543464412 33568.38163092382 31089.672637638687 1.0823778061096387 1.070301206210766 1.285471627450161 1.0549619122843115 1.1796961938286847 1.0015811900591198 1.0539520284912907 1.1350516888982056 1.0797277289528062 1.0 14.924147805281443 -6.753552014631006 24.999981126611047 1.0624963492054913 1.1349533823030316 0.2361412080605394 0.07158984726143056 306.05767196211633 970086.7009893829 0.023818506426969577 0.023411848735352864 1.763794505484266e-07 6.753552014631006 0.07245703309754026 SLSDS(ph)ESDDSK ddPTM_A459_Selumetinib_30min_R1 1 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.137)LS(0.28)DS(0.583)ESDDSK 213.63 2.0001e-05 42407000.0 3426.0 4132.9 4299.5 3773.6 3263.0 3327.8 3797.5 3915.5 2270.9 3358.4 True False 3505.8191341644647 3649.0181466669155 3715.6515154629788 3114.6115992450527 2967.862226129441 3294.325353400648 3511.0515176152103 3811.648220663534 3853.55144002631 3789.4833535862313 0.925144355323974 0.9629328872004717 0.9805166479875467 0.821909297027917 0.7831838668246853 0.8693336389202018 0.9265251196558172 1.0058490472207318 1.0169068130037957 1.0 11.887785453895662 -7.6629740956151995 3.2859648885954407 1.01036702497027 0.89024801027371 0.46493739900234055 0.05608646264477989 0.25858451762347845 5.492187866372807 0.03574330677879588 0.018411865738435774 2.172830777945277e-08 7.6629740956151995 -0.12011901469656006 SLSDS(ph)ESDDSKSK ddPTM_A459_Selumetinib_30min_R1 1 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 SLS(0.135)DS(0.865)ESDDSKSK 217.2 8.9815e-08 44367000.0 2586.8 1759.0 9429.5 8404.5 4817.8 3706.4 2979.9 3432.9 3291.2 2199.8 True False 2647.067406963406 1553.0554622630852 8149.025692535906 6936.811847004199 4382.030840651673 3669.1169811419445 2755.1237438687444 3341.848340369263 5584.926020262711 2482.165757866541 1.0664345838203009 0.6256856365619837 3.2830304207967633 2.794661003206528 1.765406208978604 1.478191764395141 1.109967670425369 1.3463437442798472 2.2500213785331726 1.0 11.277383745846354 -6.65217443790896 4.391118663638047 1.438827918608305 1.9785150702386398 0.08560116613017599 0.7751567953477153 0.6164997133453185 20.803635798762507 0.2884013544677909 0.2860763032131589 2.2275402599098643e-07 6.65217443790896 0.5396871516303348 SLSDSES(ph)DDSK ddPTM_A459_Selumetinib_30min_R1 1 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 SLSDS(0.235)ES(0.764)DDSK 168.83 0.00045652 20198000.0 2952.0 3584.8 3169.8 2519.9 2467.9 2885.0 2937.7 2783.0 1815.1 2774.1 True False 3020.775856407908 3165.0899494716928 2739.358570465065 2079.846769381391 2244.6788807431335 2855.979519370416 2716.106923844162 2709.1857995419787 3080.092130341164 3130.1827570222586 0.9650477594738177 1.0111518065106977 0.8751433328675721 0.664448989349091 0.7171079310648607 0.9124002465872976 0.8677151254989319 0.865504032780254 0.9839975392590988 1.0 11.612031176629094 -8.273082061956451 3.5158928276541537 1.0004729126056646 0.8550148807256823 0.22640007700976084 0.09781913901621177 0.3989450679371956 10.023966895950657 0.10026646505397613 0.02877875772339595 5.332341289061669e-09 8.273082061956451 -0.1454580318799823 SLSDSES(ph)DDSK ddPTM_A459_Selumetinib_30min_R2 1 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 S(0.001)LS(0.135)DS(0.28)ES(0.583)DDS(0.001)K 84.89200000000002 0.035643 5082400.0 20701.0 16729.0 20354.0 17853.0 19800.0 14993.0 17804.0 18170.0 17197.0 17581.0 True False 19550.521292668804 18012.06050778683 19044.44579975959 15421.390601857196 17312.546985754125 17058.14965709695 18631.921277956713 18222.871691794568 20636.88052432693 17073.390849076204 1.1450871982894149 1.054978514051965 1.1154460158563073 0.9032412329910204 1.0140075359834488 0.9991073131216885 1.091284176802222 1.067325867068788 1.2087159900895454 1.0 14.059461991830284 -7.3916439823531945 6.386459358365706 1.0988377859841576 1.0357025043892236 0.0975590808609168 0.07803900196591637 0.5454854389075845 25.94834482898578 0.03360596620800423 0.022448322728926367 4.058410917907811e-08 7.3916439823531945 -0.06313528159493398 SLSDSESDDSK ddPTM_A459_Selumetinib_30min_R1 1 SLSDSESDDSK 11 0 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 0 208.6 0.0002527 5952100.0 1741.0 2214.6 1885.4 1981.3 1664.3 1736.7 1584.6 1811.2 1278.9 1796.0 False True 1781.5619126037152 1955.313602460391 1629.3730357608786 1635.3031486072252 1513.7643588560306 1719.2303747974336 1465.0723462312205 1763.1610923932576 2170.199892839688 2026.534094521458 0.8791176607489597 0.9648560109333444 0.8040195524791482 0.8069457864183542 0.7469720657295372 0.8483599557713878 0.7229448298905526 0.8700377147168635 1.0708923667786379 1.0 10.984798732232015 -8.16078106286546 4.734349770010469 1.0337094015159534 0.8249768932483166 0.6122939493130027 0.06586004493108102 0.15099387444462445 5.304505534514734 0.05134543196015932 0.018075838975422826 6.90587856207217e-09 8.16078106286546 -0.20873250826763678 SLSEGLY(ph)PYPPEMGKPATGDFGYR ddPTM_A459_Selumetinib_30min_R1 1 SLSEGLYPYPPEMGKPATGDFGYR 24 1 Q63HR2-6;Q63HR2;Q63HR2-4;Q63HR2-5;F8VV64;Q63HR2-2 Q63HR2-6 TNS2 Tensin-2 1 S(0.027)LS(0.244)EGLY(0.672)PY(0.057)PPEMGKPATGDFGYR 71.042 0.011874 13547000.0 922.86 1219.6 1487.1 1396.5 1505.7 1211.0 1096.7 1098.7 480.77 1170.4 True False 944.3608424270333 1076.8086650233424 1285.159988055586 1152.6274905516536 1369.5097008529253 1198.8184395000253 1013.9750360417643 1069.5589069194298 815.8315759484998 1320.6322406614238 0.7150823774785786 0.8153736005142771 0.9731399465243465 0.8727846065414646 1.037010651933669 0.9077609970354885 0.7677951550947494 0.8098839888868329 0.6177583363706914 1.0 10.367013056741994 -11.247097222260896 7.102685094973643 1.001703147965371 0.8451034684609154 0.14897452875265127 0.11601985320035278 0.003347834476911894 0.00012998888324792748 0.12019122728332521 0.028855921731687436 5.661125434665117e-12 11.247097222260896 -0.15659967950445564 SLSFPILNPALSQPSQPS(ph)SPLPGSHGR ddPTM_A459_Selumetinib_30min_R1 1 SLSFPILNPALSQPSQPSSPLPGSHGR 27 0 Q8ND24;E9PN76;Q8ND24-2 Q8ND24 RNF214 RING finger protein 214 1 SLSFPILNPALSQPS(0.007)QPS(0.412)S(0.29)PLPGS(0.29)HGR 84.47 4.509e-05 17889000.0 1691.0 1892.1 2682.0 2784.9 2506.0 1726.4 1683.6 1692.7 942.04 1534.2 True False 1730.39700988678 1670.5720523865734 2317.7991311714636 2298.5694940474737 2279.3327424702343 1709.0339834457827 1556.6046965258638 1647.8040973355048 1598.5730761206507 1731.129514373508 0.9995768632672217 0.9650185260639784 1.3388941219746173 1.3277859772839242 1.3166737228757375 0.9872363501723777 0.8991844247362368 0.9518664453779135 0.9234277752460195 1.0 10.75749794856631 -6.894240275126439 6.455509998590888 0.9403001145828539 1.1922769858493354 0.4860213949966601 0.12249600708214915 0.20872631612160103 11.274254784468052 0.04912419272339732 0.04331418492335249 1.2757328093476646e-07 6.894240275126439 0.2519768712664815 SLSFPILNPALSQPSQPS(ph)SPLPGSHGR ddPTM_A459_Selumetinib_30min_R2 1 SLSFPILNPALSQPSQPSSPLPGSHGR 27 0 Q8ND24;E9PN76;Q8ND24-2 Q8ND24 RNF214 RING finger protein 214 1 SLSFPILNPALSQPS(0.082)QPS(0.544)S(0.362)PLPGS(0.012)HGR 80.477 6.7007e-05 4483200.0 9682.1 8550.7 11177.0 11069.0 16229.0 8594.9 11702.0 11263.0 8841.8 10462.0 True False 9144.00764251721 9206.511195166058 10457.883988597474 9561.383104909946 14190.167930899186 9778.769458266032 12246.166187073093 11295.77346530997 10610.407060533451 10159.93487645954 0.9000065210756201 0.9061584849817734 1.0293258879865734 0.9410870464399893 1.396679024368321 0.9624834782084416 1.205339043604239 1.1117958532866343 1.0443380975913192 1.0 13.310603534247129 -6.1124823483788475 21.49947773044296 1.1263367453635624 0.9474260411463419 0.3462276739948009 0.1182281142855344 8.726010542035402 1650.1613202117553 0.033102557212057265 0.0427352723459419 7.718228851945052e-07 6.1124823483788475 -0.17891070421722055 SLSFPILNPALSQPSQPSS(ph)PLPGSHGR ddPTM_A459_Selumetinib_30min_R2 1 SLSFPILNPALSQPSQPSSPLPGSHGR 27 0 Q8ND24;E9PN76;Q8ND24-2 Q8ND24 RNF214 RING finger protein 214 1 SLSFPILNPALSQPS(0.004)QPS(0.125)S(0.771)PLPGS(0.1)HGR 97.046 1.4297999999999996e-06 4603400.0 14913.0 12405.0 18933.0 17992.0 20796.0 16616.0 13548.0 14872.0 13500.0 17575.0 True False 14084.19516146901 13356.423611638218 17714.871392691774 15541.458562068821 18183.42056140116 18904.70317496984 14178.008844852708 14915.275057807863 16200.377221516159 17067.56408466607 0.825202418552663 0.7825617964802584 1.037926168304665 0.9105844562805337 1.065378777615817 1.1076392085707356 0.8306990250348957 0.8738959457728429 0.949190941434401 1.0 14.058969548416393 -5.250909639046075 24.92666821307244 0.9683621782063337 0.8038820854664445 0.40168178969838586 0.0819392125603509 741.8442063924381 1756131.65922951 0.022479649903521227 0.05813640104669305 5.611647219430861e-06 5.250909639046075 -0.16448009273988928 SLSGS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 2 SLSGSPLK 8 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 S(0.013)LS(0.034)GS(0.953)PLK;S(0.088)LS(0.088)GS(0.825)PLK 120.45 0.0073788 246560000.0 8436.6 14459.7 11675.1 14196.4 10292.6 12194.599999999999 10141.900000000001 8947.3 5777.2 8755.6 True False 8633.15636523407 12766.751601867849 10089.685546733765 11717.2652394325 9361.636147306117 12071.933395810905 9376.888317709472 8709.988539073645 9803.486450006596 9879.46654676619 0.8738484334521006 1.2922511090486706 1.0212783756058554 1.1860220573617781 0.9475851862032396 1.2219215823715064 0.9491290115030324 0.8816253891688771 0.9923092915594248 1.0 13.27021742858615 -7.372114159319053 11.054062379271938 0.9453724502661366 1.0943243349396683 0.22462442015073725 0.12190015680866881 0.6978641694021237 65.85319696078338 0.047027207586050966 0.03168498980293162 4.245079624596665e-08 7.372114159319053 0.1489518846735317 SLSGS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 SLSGSPLK 8 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 SLS(0.165)GS(0.835)PLK 99.568 0.018546 89515000.0 88327.0 86910.0 95534.0 90104.0 83477.0 68339.0 78832.0 79291.0 63137.0 77966.0 True False 83418.13894099602 93575.71754030447 89387.4464495544 77831.67976193014 72989.87296615138 77752.07693032407 82497.84420264453 79521.72368266841 75766.16419517517 75714.91900000442 1.1017397897631134 1.235895366147047 1.1805790408301062 1.0279569837739058 0.9640091270010752 1.0269056344142629 1.0895850552602415 1.0502781318786563 1.0006768176714387 1.0 16.20828997892375 -5.763760254196343 10.15854801539661 1.025322146282888 1.179157588541372 0.7125588326572867 0.04357015939554303 0.05285936008791703 100.78933611362771 0.012469819793462155 0.019798389555584602 1.722819369312201e-06 5.763760254196343 0.153835442258484 SLSGS(ph)SPCPK ddPTM_A459_Selumetinib_30min_R1 6 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SLS(0.001)GS(0.976)S(0.023)PCPK;SLSGS(0.809)S(0.191)PCPK;SLS(0.023)GS(0.488)S(0.488)PCPK;S(0.463)LS(0.066)GS(0.469)S(0.002)PCPK;SLS(0.001)GS(0.499)S(0.499)PCPK;S(0.354)LS(0.14)GS(0.391)S(0.114)PCPK 179.94 0.00011593 753463000.0 39528.899999999994 43125.399999999994 46704.299999999996 49314.700000000004 39966.0 35413.8 40035.2 35609.2 20506.500000000004 31856.9 True False 40449.846460149914 38076.25811954545 40362.11258835619 40702.81339656829 36351.08235657041 35057.56932515769 37015.31263147556 34664.728341017 34798.03276449845 35946.04342748367 1.1252934287956353 1.0592614510233704 1.1228527186804675 1.1323308357616815 1.0112679697253426 0.9752831183181992 1.0297465062086455 0.9643544889981687 0.9680629478651473 1.0 15.133545361850105 -6.366145591454832 4.660842998752799 0.9885775469718608 1.1069484950482062 0.836128200735012 0.025805956996144103 0.09128889299027199 3.2055994324819386 0.008327243486711515 0.009497347209244797 4.303823063550813e-07 6.366145591454832 0.1183709480763454 SLSGS(ph)SPCPK ddPTM_A459_Selumetinib_30min_R2 1 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SLSGS(0.5)S(0.5)PCPK 166.29 0.00033071 22621000.0 86121.0 76362.0 93039.0 85887.0 86515.0 66024.0 68368.0 67385.0 61421.0 64206.0 True False 81334.73958967824 82218.71985747019 87052.97203320397 74189.04243666094 75646.21224608675 75118.20669380177 71547.24746862186 67581.07919381278 73706.91624612924 62352.205952777826 1.3044404499702345 1.3186176591689183 1.396149032788562 1.1898382952617217 1.2132082753155051 1.2047401618908595 1.1474693858114315 1.0838602766515593 1.1821059915979695 1.0 15.928152981478258 -6.556992378661312 0.25004090855457456 0.9888547387749536 1.4555640280052322 0.7760384013673809 0.05187543260064653 1.817121616424906 0.22328616365826784 0.09724090458407106 0.2721466076125133 2.773368773465625e-07 6.556992378661312 0.46670928923027866 SLSGSS(ph)PCPK ddPTM_A459_Selumetinib_30min_R2 5 SLSGSSPCPK 10 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SLSGS(0.016)S(0.984)PCPK;SLSGS(0.038)S(0.962)PCPK;SLS(0.002)GS(0.08)S(0.918)PCPK;SLSGS(0.052)S(0.948)PCPK;SLSGS(0.034)S(0.966)PCPK 193.3 3.2669000000000003e-19 895561000.0 1047024.0 1016591.0 1000749.0 1127617.0 1134970.0 797699.0 884092.0 855937.0 686660.0 882907.0 True False 988834.5976491603 1094560.2608447303 936361.8988731268 974033.6193521748 992384.921839463 907574.7964594519 925204.0297950635 858427.6349620026 824011.1868834292 857415.1808421222 1.1532739561223568 1.2765813870588258 1.0920752510510323 1.1360116325389926 1.1574146854558587 1.0585009651544364 1.0790618716201894 1.0011808213132942 0.9610410514006938 1.0 19.709634435248987 -6.966368310266718 0.5934366811861592 0.9709144137705185 1.1978088892347598 0.7233203349911304 0.046808543163784376 0.4328876100007687 0.32458607289790736 0.04000605309135199 0.03787364589547141 1.080517213006971e-07 6.966368310266718 0.22689447546424135 SLSKPEPTYVS(ph)PPCPR ddPTM_A459_Selumetinib_30min_R2 1 SLSKPEPTYVSPPCPR 16 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 SLSKPEPT(0.074)Y(0.008)VS(0.918)PPCPR 76.329 0.016214 4721200.0 25881.0 25575.0 28593.0 31054.0 31245.0 22891.0 24455.0 26860.0 22785.0 26536.0 True False 24442.637629851786 27536.52026341372 26753.35750970453 26824.391628861995 27319.723766155963 26044.027466191295 25592.205956663183 26938.15815308763 27342.63666609228 25769.83673119196 0.9484979623586933 1.0685562563181998 1.038165580510726 1.0409220635997898 1.0601434557436684 1.0106399872789047 0.9931070275538931 1.0453367801310718 1.061032592146639 1.0 14.653395776357154 -4.747651048056172 24.9788246877348 1.0356883147406872 0.9484977431221591 0.5240212984946646 0.024822475996381082 590.8611710569896 1070336.1984668938 0.006335798286297875 0.1267621426772847 1.7879235793434355e-05 4.747651048056172 -0.08719057161852817 SLSKS(ph)DSDLLTCSPTEDATMGSR ddPTM_A459_Selumetinib_30min_R1 1 SLSKSDSDLLTCSPTEDATMGSR 23 1 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.072)LS(0.203)KS(0.51)DS(0.203)DLLT(0.009)CS(0.002)PTEDATMGSR 51.554 0.020394 10566000.0 3183.2 3559.1 3737.4 3579.9 3215.1 3337.8 3302.5 2930.4 1807.4 2785.4 True False 3257.362366571023 3142.398917419301 3229.88160806869 2954.73766804573 2924.294772672009 3304.22476247992 3053.3897661419965 2852.6762727193036 3067.0257927269154 3142.9332220935803 1.0364083919037959 0.9998299980825163 1.0276647258566924 0.9401210459309445 0.9304349046029265 1.0513187933019144 0.9715095900472436 0.9076477516818096 0.975848220753446 1.0 11.617895904180903 -5.749329546849914 24.964716460861133 0.9663146642296526 1.0191539497692634 0.28732595198228694 0.038258485198110564 305.6145679239356 630026.270662218 0.010829680817001763 0.01857838452151663 1.7810267942243877e-06 5.749329546849914 0.052839285539610814 SLSKS(ph)DSDLLTCSPTEDATMGSR ddPTM_A459_Selumetinib_30min_R2 4 SLSKSDSDLLTCSPTEDATMGSR 23 1 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.062)LS(0.207)KS(0.585)DS(0.146)DLLTCSPTEDATMGSR;S(0.006)LS(0.159)KS(0.705)DS(0.124)DLLT(0.005)CS(0.001)PTEDATMGSR;S(0.014)LS(0.205)KS(0.572)DS(0.208)DLLT(0.001)CSPTEDATMGSR;S(0.016)LS(0.245)KS(0.732)DS(0.007)DLLTCSPTEDATMGSR 129.2 4.627e-06 45498100.0 157024.0 160862.0 162528.0 179912.0 172080.0 119296.0 117802.0 113560.0 101209.0 147115.0 True False 148297.23469687588 173199.59814714635 152071.12542710674 155407.67523448926 150461.7719852812 135727.94113873388 123280.02642023467 113890.44079913001 121453.62801573529 142867.40769932573 1.0380060580995323 1.212310077828645 1.064421395166285 1.0877755657298365 1.0531567304835427 0.9500273248072272 0.862898182346011 0.7971758054070684 0.8501143120853903 1.0 17.124317306800833 -6.826201155888392 1.723605751900448 0.8592074065623044 1.1073706601370996 0.7115210855831995 0.06476268413968565 0.1747510424525197 1.07161450510368 0.027228552586611696 0.02363711330550051 1.4921031393320833e-07 6.826201155888392 0.24816325357479518 SLSKSDS(ph)DLLTCSPTEDATMGSR ddPTM_A459_Selumetinib_30min_R1 1 SLSKSDSDLLTCSPTEDATMGSR 23 1 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.062)LS(0.152)KS(0.333)DS(0.441)DLLT(0.009)CS(0.002)PT(0.001)EDATMGSR 52.463 0.017121 27078000.0 4642.9 5539.6 6366.0 6493.3 5930.9 4990.9 5944.8 4989.4 3007.5 4296.0 True False 4751.070536489252 4891.0210567098275 5501.532165934952 5359.367049336951 5394.45114218544 4940.696077374629 5496.378949814059 4857.064904144719 5103.507840890892 4847.433446583623 0.9801208389643213 1.0089918944956169 1.1349371222027453 1.105609207097857 1.1128468707471053 1.0192395897372735 1.1338740408468733 1.0019869189886215 1.0528267994040734 1.0 12.243005375476281 -10.024613732298363 11.309615796209101 0.9999999999999714 1.0637878085755752 0.09904412484701497 0.05482418920546276 0.0 0.0 0.05456388642646661 0.013233686298854568 9.449009109978056e-11 10.024613732298363 0.06378780857560384 SLSLDPGQS(ph)LEPHPEGPQR ddPTM_A459_Selumetinib_30min_R2 1 SLSLDPGQSLEPHPEGPQR 19 0 P98174 P98174 FGD1 FYVE, RhoGEF and PH domain-containing protein 1 1 S(0.018)LS(0.43)LDPGQS(0.552)LEPHPEGPQR 81.01 0.0059823 2334900.0 7433.5 8716.5 14207.0 13378.0 16413.0 8121.2 10059.0 12522.0 12192.0 11101.0 True False 7020.375828658214 9385.027522035032 13292.937087412027 11555.893321662776 14351.05220591831 9239.821583086494 10526.763431530359 12558.436946871312 14630.740672942591 10780.485286138159 0.6512114846708436 0.8705570549873628 1.2330555382793804 1.0719270065255464 1.331206511117944 0.8570877226619202 0.9764647093453165 1.164923156383256 1.357150470002978 1.0 13.396134502365904 -5.006091660014914 3.40659706830692 1.119932979947707 0.6657878220934117 0.5080978108628748 0.1499252362020224 0.19854160228337348 4.68333695662897 0.0397550041866124 0.17630149823584476 9.860713483951582e-06 5.006091660014914 -0.4541451578542952 SLSLEAT(ph)SPLSAEK ddPTM_A459_Selumetinib_30min_R1 2 SLSLEATSPLSAEK 14 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 SLSLEAT(0.661)S(0.339)PLSAEK;S(0.002)LS(0.154)LEAT(0.527)S(0.315)PLS(0.002)AEK 236.42 5.9303e-19 32226000.0 9455.6 10641.3 12775.5 12671.8 10940.6 9809.3 10545.8 9168.8 5738.6 8541.5 True False 9675.897082605226 9395.411648993837 11040.657270798289 10458.908009146036 9951.024661719817 9710.627348131782 9750.321815527715 8925.613639540246 9737.985069239061 9637.884726255588 1.003944055924023 0.974841670745324 1.145547761192999 1.0851870826649141 1.0324905250849463 1.0075475712713213 1.0116661583392696 0.9260967414587385 1.0103861320016392 1.0 13.234500830515467 -6.963253893329692 1.8041490143447587 0.9796810065293147 1.052813318349389 0.27041385360307835 0.048317663367602716 0.4809459949009289 3.1735175208559196 0.02353949760265175 0.018495935592171116 1.0882936788723936e-07 6.963253893329692 0.0731323118200744 SLSLEAT(ph)SPLSAEK ddPTM_A459_Selumetinib_30min_R2 3 SLSLEATSPLSAEK 14 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 SLSLEAT(0.333)S(0.333)PLS(0.333)AEK;SLSLEAT(0.498)S(0.498)PLS(0.004)AEK;SLSLEAT(0.629)S(0.367)PLS(0.003)AEK 227.92 8.4903e-13 24842000.0 244894.0 226053.0 269495.0 282322.0 292006.0 222107.0 214780.0 248810.0 202381.0 267574.0 True False 231283.77186835615 243390.5382250421 252155.98510397074 243869.25656738522 255321.59571323838 252700.22316339848 224767.6955784962 249533.9959072869 242862.85499760447 259848.44337925676 0.890071800548716 0.9366634452753144 0.9703963657613348 0.9385057435631837 0.9825788924992277 0.972490809939449 0.864995351349636 0.9603059100996206 0.9346327106648805 1.0 17.987310891011404 -4.797971019201736 3.631143488306268 0.9498724433169812 0.8844861501073666 0.22305188851369495 0.03493590899278512 0.41593984392685696 9.381182479979772 0.008786139636106105 0.07206233687525773 1.5923149798852836e-05 4.797971019201736 -0.06538629320961453 SLSLEATS(ph)PLSAEK ddPTM_A459_Selumetinib_30min_R2 1 SLSLEATSPLSAEK 14 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 SLSLEAT(0.226)S(0.774)PLSAEK 191.01 0.00010454 5758600.0 62817.0 61711.0 62887.0 60733.0 72107.0 47695.0 56387.0 53161.0 44159.0 61946.0 True False 59325.882616374925 66444.0352678602 58840.91888618853 52461.06062973135 63048.274015241 54264.553317897604 59009.1072287208 53315.689708722704 52992.03390555053 60157.45802496299 0.9861766863845379 1.1045020426276744 0.9781151135370755 0.8720624566277728 1.0480541579579117 0.9020419927879921 0.9809109155548815 0.8862689923932421 0.880888848121889 1.0 15.876455986254822 -5.513939899457328 23.892275484443243 0.9376205994857727 1.0443316970084149 0.33021622037212217 0.060317886382640816 236.0868927418456 631024.7048501134 0.015477753293898841 0.02879405361161893 3.0623871977623095e-06 5.513939899457328 0.10671109752264218 SLSNS(ph)NPDISGTPTSPDDEVR ddPTM_A459_Selumetinib_30min_R1 3 SLSNSNPDISGTPTSPDDEVR 21 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 S(0.047)LS(0.187)NS(0.766)NPDISGTPTSPDDEVR;SLS(0.003)NS(0.963)NPDIS(0.03)GT(0.004)PTSPDDEVR;SLS(0.007)NS(0.992)NPDIS(0.001)GTPTSPDDEVR 293.72 5.192999999999998e-87 31883000.0 1800.78 2144.8599999999997 2156.66 2191.2 2252.66 1759.75 2032.1600000000003 2075.49 940.04 1636.5700000000002 True False 1842.734670292084 1893.7387940816368 1863.7974176854023 1808.548053918212 2048.907300739424 1742.048512725161 1878.872535098599 2020.4412630583474 1595.1792221948708 1846.639701041751 0.9978853315308536 1.0255052964654208 1.009291317972841 0.9793724530551084 1.1095327906053178 0.943361345335754 1.0174548581613752 1.09411774366085 0.863828077179851 1.0 10.850686693361217 -8.26362457189712 24.999921419000376 0.9319140489570096 1.0204693816173547 0.2956433365084208 0.055616381287483585 237.6190840337198 2718402.371005823 0.0426297804397671 0.013193330432776502 5.449735544739387e-09 8.26362457189712 0.0885553326603451 SLSNS(ph)NPDISGTPTSPDDEVR ddPTM_A459_Selumetinib_30min_R2 2 SLSNSNPDISGTPTSPDDEVR 21 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SLSNS(0.999)NPDIS(0.001)GT(0.001)PTSPDDEVR;SLSNS(0.999)NPDIS(0.001)GTPTSPDDEVR 351.15 1.5881999999999987e-195 181230000.0 88755.0 86880.0 114036.0 124611.0 125656.0 89402.0 89464.0 108048.0 78242.0 98641.0 True False 83822.35241441568 93543.41663676957 106699.04791300898 107638.76683403517 109869.96990110721 101716.31398944721 93624.25326955278 108362.40179169069 93892.5862641382 95792.97802990285 0.8750365020309693 0.9765164269928945 1.1138504106188418 1.123660304207627 1.1469522313713858 1.0618347616011616 0.9773602950346415 1.131214458724356 0.9801614710718001 1.0 16.547632284647328 -4.97178938709278 3.197737133650994 1.072694601556035 0.876882482869573 0.49701814089125684 0.06060260448145084 0.21159187684755373 4.166127228129339 0.01586053806246006 0.08270439423794146 1.067113496877141e-05 4.97178938709278 -0.19581211868646198 SLSNSNPDIS(ph)GTPTSPDDEVR ddPTM_A459_Selumetinib_30min_R2 2 SLSNSNPDISGTPTSPDDEVR 21 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A0U1RRC1;A0A0U1RQJ5 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SLSNS(0.012)NPDIS(0.76)GT(0.221)PT(0.005)S(0.002)PDDEVR;SLS(0.001)NS(0.001)NPDIS(0.499)GT(0.499)PTSPDDEVR 226.23 1.0634e-24 24562000.0 56581.0 44475.0 64108.0 61900.0 76704.0 50848.0 46256.0 47660.0 45869.0 46859.0 True False 53436.454531688985 47886.08949033534 59983.361075512854 53469.11321654402 67067.75777753963 57851.850447813384 48406.99565452517 47798.68270946228 55044.081686942576 45506.058915696594 1.174271202669606 1.0523013996674142 1.3181401005663125 1.174988880395017 1.473820396132034 1.27129995051842 1.0637483624807584 1.0503806272921359 1.2095989632702733 1.0 15.473771025644966 -7.262270440301688 24.933982843902918 1.0851303684887723 1.246078028072771 0.3295587225836415 0.1139558215417045 96.7937100100132 2903993.000832854 0.04812270855394364 0.034617019248725664 5.4667543563132226e-08 7.262270440301688 0.1609476595839987 SLSPQEDALT(ph)GSR ddPTM_A459_Selumetinib_30min_R1 1 SLSPQEDALTGSR 13 0 Q96EN8 Q96EN8 MOCOS Molybdenum cofactor sulfurase 1 SLS(0.002)PQEDALT(0.499)GS(0.499)R 115.12 0.0095105 3222100.0 1033.1 1167.9 1073.8 1039.4 959.25 1007.5 1166.9 1124.4 621.7 895.79 True False 1057.1692199373342 1031.16172505802 927.9838579611921 857.8883019544497 872.4860068693428 997.3654647368081 1078.8797935234197 1094.5772594340647 1054.979492828551 1010.7733722335063 1.0459013355301465 1.0201710426734547 0.9180929013895824 0.848744461934898 0.8631865765729563 0.9867350012722726 1.067380506017307 1.082910659800403 1.0437349477236053 1.0 9.981243848267269 -7.059013103687437 4.592309217895714 1.0538004564739085 0.9363027705111 0.41739662358358764 0.06049016404387902 0.23131768880794443 9.949584594084694 0.026621398184589303 0.020901776385326983 8.729450291831299e-08 7.059013103687437 -0.11749768596280852 SLSPS(ph)GLK ddPTM_A459_Selumetinib_30min_R2 1 SLSPSGLK 8 0 F6VUX8;Q9HC77-2;Q9HC77 F6VUX8 CENPJ Centromere protein J 1 S(0.012)LS(0.027)PS(0.961)GLK 87.806 0.031954 2277400.0 33208.0 34493.0 32922.0 37829.0 39326.0 26068.0 31570.0 31935.0 24150.0 32339.0 True False 31362.432302156696 37138.502187524144 30803.834362763366 32676.624941335107 34385.51630109936 29658.630378256745 33038.067554768226 32027.92556287615 28980.6748073789 31405.289043187262 0.9986353654961866 1.182555656037835 0.9808486182185172 1.0404815856462761 1.094895711795991 0.9443832959942325 1.0519905583207858 1.0198258490419452 0.9227959904309706 1.0 14.938719927004168 -6.749319208812124 0.5566761152705619 0.9775942452456932 1.075659847810214 0.18207364688411176 0.06452310376293251 1.5432903940506297 1.0345722328278502 0.053434103856228314 0.06523217128173799 1.7810691906678576e-07 6.749319208812124 0.09806560256452079 SLSQGST(ph)NSNMLDVQGGAHK ddPTM_A459_Selumetinib_30min_R2 1 SLSQGSTNSNMLDVQGGAHK 20 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;B7Z7Y1;Q8TEU7-2 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 S(0.079)LS(0.333)QGS(0.136)T(0.439)NS(0.013)NMLDVQGGAHK 138.24 0.00011765 2788500.0 9437.6 10036.0 8368.6 13520.0 11859.0 8890.2 9010.7 9613.8 9629.6 14818.0 True False 8913.095973706164 10805.72892917381 7830.17338704275 11678.55267669912 10369.166399194864 10114.744352799531 9429.715404363324 9641.774566349734 11555.789073504593 14390.165838212348 0.619387995518293 0.7509106601453995 0.5441336448152756 0.811564842823932 0.7205730994190542 0.7028928274016374 0.6552888625732998 0.6700252571618386 0.8030337664920294 1.0 13.812795597936757 -8.598486739751143 2.7566651057070692 0.99963630505741 0.6872750653093118 0.6650214471114434 0.06898300118412613 0.2013144541080295 3.647374175237834 0.06385362347782945 0.01712658139945317 2.520654141222364e-09 8.598486739751143 -0.31236123974809815 SLSQGSTNS(ph)NMLDVQGGAHK ddPTM_A459_Selumetinib_30min_R2 1 SLSQGSTNSNMLDVQGGAHK 20 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;B7Z7Y1;Q8TEU7-2 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 S(0.048)LS(0.218)QGS(0.003)T(0.001)NS(0.73)NMLDVQGGAHK 171.9 8.765e-10 4087000.0 19194.0 16782.0 20714.0 21181.0 21767.0 16868.0 18136.0 23217.0 17474.0 27887.0 True False 18127.274319669832 18069.12543736498 19381.28379169796 18296.111260736976 19032.434860551013 19191.4138875416 18979.35993580224 23284.55762621874 20969.28826435358 27081.829850872415 0.669351901975925 0.6672047471261584 0.7156563606824968 0.6755862274257507 0.70277506968156 0.7086453904045692 0.700815271357701 0.8597852417815353 0.7742936271227654 1.0 14.725037601017416 -8.711731377690375 0.46837615794212 1.013812502749337 0.6711983588840658 0.8765947527143705 0.03539358748506755 0.42270957207268806 0.21158853592981416 0.04768755824347441 0.02056588358429015 1.9420867367817527e-09 8.711731377690375 -0.3426141438652712 SLSRTPETLLPFAEAEAFLKK ddPTM_A459_Selumetinib_30min_R1 1 SLSRTPETLLPFAEAEAFLKK 21 2 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 0 89.344 0.00051774 1071900.0 387.19 470.16 645.21 747.43 455.21 519.76 278.85 285.86 60.93 329.47 False True 396.21077365941017 415.11344862854594 557.5940258848397 616.9053814987624 414.03633587385326 514.5316863043214 257.81611999657713 278.2780641958571 103.39375984887181 371.7606838095685 1.0657683582870912 1.116614711310313 1.4998735750401806 1.6594153399361815 1.1137173829977678 1.3840400793105014 0.693500230725424 0.7485408659792623 0.27811913510960307 1.0 8.538230393404405 -7.268496689795908 19.799030082026505 0.6590839259279888 1.3139960017258328 0.6225180926109914 0.23874757015574846 21.48958537488974 60284.540103397514 0.09977624517408658 0.06939520170644449 5.3889395282167444e-08 7.268496689795908 0.6549120757978439 SLSS(ph)PPSSK ddPTM_A459_Selumetinib_30min_R2 1 SLSSPPSSK 9 0 Q5VW31;A0A1B0GWB8;A0A2R8Y7V8;Q5VW30;Q5VW27;A0A1B0GWI9;A0A1B0GU97;A0A0A0MRX8;A0A1B0GWJ4;A0A1B0GVN4;U3KQE8;A0A1B0GW37;Q5VW26;O00712-4;O00712;O00712-5;O00712-6 Q5VW31 NFIB Nuclear factor 1;Nuclear factor 1 B-type 1 S(0.026)LS(0.108)S(0.863)PPS(0.003)SK 83.86200000000002 0.037731 15173000.0 44075.0 44948.0 51935.0 46169.0 49843.0 38843.0 42112.0 37802.0 31905.0 41130.0 True False 41625.48794620445 48395.36706940063 48593.55864255253 39880.70255403268 43581.2767379264 44193.270668353 44070.29144334493 37911.99756154203 38286.89150018318 39942.4700314262 1.042136050010279 1.211626798025355 1.2165887238400572 0.9984535889406708 1.091101193883033 1.1064230788326892 1.1033441699692337 0.9491650749618985 0.9585509226159414 1.0 15.285635930956877 -7.743438242368417 8.974822740350934 0.9653124687226139 1.112956134498622 0.5045835032075402 0.06381331611129888 0.16653641293542187 72.7419891130513 0.032693058658289705 0.018201731369320934 1.8053514438294533e-08 7.743438242368417 0.14764366577600818 SLSS(ph)PTDNLELSLR ddPTM_A459_Selumetinib_30min_R1 1 SLSSPTDNLELSLR 14 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 SLS(0.067)S(0.932)PTDNLELSLR 291.13 1.1327999999999995e-66 72082000.0 2164.8 2737.0 2846.0 2583.9 2994.2 2288.8 2503.1 2235.9 1329.0 2215.2 True False 2215.2356280324657 2416.550767603221 2459.52883195898 2132.67037081018 2723.3751386689437 2265.776750064126 2314.2891517426283 2176.596668773235 2255.2159336804625 2499.542497875243 0.8862564368941697 0.9667972317563835 0.9839916040834364 0.853224289094134 1.0895494439418298 0.9064765860113075 0.9258850984569813 0.8707980242878323 0.9022514862609968 1.0 11.287448340970437 -9.890315245302647 7.277544005696736 1.0000000000000073 0.933894496529244 0.0892704024865626 0.06511234683331728 0.0 0.0 0.06195904279770647 0.01502727505963272 1.287314777531091e-10 9.890315245302647 -0.06610550347076338 SLSS(ph)PTDNLELSLR ddPTM_A459_Selumetinib_30min_R2 2 SLSSPTDNLELSLR 14 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 S(0.002)LS(0.026)S(0.941)PT(0.031)DNLELSLR;SLS(0.019)S(0.811)PT(0.17)DNLELSLR 204.17 2.6861e-05 16865000.0 60898.0 61703.0 66125.0 81232.0 62735.0 45434.0 59197.0 63062.0 55883.0 53425.0 True False 57513.53295400921 66435.42169358424 61870.58949145638 70168.06146698409 54853.668441984126 51692.121091212095 61949.7777966302 63245.49997952388 67061.16150148053 51882.48143517982 1.1085347377970853 1.28049815382455 1.1925140775842682 1.3524422796671673 1.057267634943722 0.9963309321624187 1.1940403790059293 1.2190145542390955 1.2925588685511202 1.0 15.66295986200367 -6.276856285852934 24.95454905431812 1.134351155179204 1.2339271537914362 0.19413530464179019 0.10604483350315014 1512.6625970061386 2448464.2090163487 0.03429242129343653 0.03901885929288744 5.286201506717239e-07 6.276856285852934 0.09957599861223221 SLSS(ph)SPVK ddPTM_A459_Selumetinib_30min_R2 1 SLSSSPVK 8 0 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 SLS(0.002)S(0.499)S(0.499)PVK 97.965 0.019842 7365800.0 117500.0 123350.0 121940.0 129880.0 130250.0 92963.0 105520.0 108280.0 103260.0 124010.0 True False 110969.82038976788 132810.54836723694 114094.5131582337 112190.1199445032 113886.83055022612 105767.80941590766 110426.88908391321 108595.07687328097 123914.88532546333 120429.50908332503 0.9214504089108924 1.1028073549261543 0.9473966474387258 0.931583303780463 0.9456721314991657 0.878254924569418 0.9169421176292347 0.901731458509427 1.0289412143972685 1.0 16.877829416301225 -5.491797419243014 24.71691572839251 0.9358059903712601 1.015372190945664 0.17122658427694382 0.05848543945435754 773.7570732974232 615316.0576525953 0.014443628121040442 0.030010675808268637 3.222571639681212e-06 5.491797419243014 0.079566200574404 SLSS(ph)SPVKK ddPTM_A459_Selumetinib_30min_R1 1 SLSSSPVKK 9 1 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 SLS(0.014)S(0.493)S(0.493)PVKK 152.54 0.0019687000000000003 193370000.0 9724.0 10491.0 11140.0 12361.0 9635.5 8722.6 8984.2 8627.3 5068.0 8133.7 True False 9950.55028038973 9262.708842866416 9627.249187639853 10202.38339470747 8763.970726285697 8634.85856348713 8306.514560779082 8398.475978580136 8600.025847925199 9177.739623947211 1.084204901000465 1.0092581858279677 1.0489782432397352 1.1116444585207763 0.9549160343815074 0.9408480646973731 0.9050719350443472 0.9150919859031776 0.9370527167152792 1.0 13.163923162171844 -6.392137812227616 5.495531799815668 0.9338103112684822 1.058138636075342 0.7499145026575507 0.03424415632810531 0.11313490722893783 4.59045886664911 0.010731118277834207 0.01216723172428558 4.0537987811754014e-07 6.392137812227616 0.12432832480685974 SLSSS(ph)PQAQPPRPAELSDEEVAELFQR ddPTM_A459_Selumetinib_30min_R2 3 SLSSSPQAQPPRPAELSDEEVAELFQR 27 1 A0A087WXA6;A0A087WT45;Q4V328-4;Q4V328 A0A087WXA6 GRIPAP1 GRIP1-associated protein 1 1 S(0.026)LS(0.083)S(0.285)S(0.6)PQAQPPRPAELS(0.006)DEEVAELFQR;S(0.002)LS(0.02)S(0.068)S(0.829)PQAQPPRPAELS(0.08)DEEVAELFQR;S(0.002)LS(0.021)S(0.1)S(0.758)PQAQPPRPAELS(0.119)DEEVAELFQR 85.01299999999998 3.5519e-05 59403500.0 21508.0 24263.1 27047.6 26321.800000000003 33686.6 19096.7 21381.6 15794.380000000001 14324.8 27302.9 True False 20312.671463345767 26124.001751837095 25307.386863200234 22736.725432362327 29454.58814597501 21727.097082417364 22375.886766836622 15840.339030899628 17190.160268353688 26514.59433554649 0.7660939936053939 0.985268770143477 0.9544700757224927 0.8575173787169956 1.110882096600175 0.8194391665004347 0.8439083202128664 0.5974196259779639 0.6483282395653285 1.0 14.69449905544382 -7.304190032496316 2.386013938277281 0.7232772362597932 0.9324317398979722 0.2219013398137467 0.13424518178523898 0.35821856030078486 3.9998063209753987 0.06284867792948191 0.04007907987435099 4.9637507707082685e-08 7.304190032496316 0.209154503638179 SLSSS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 SLSSSPVK 8 0 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 SLS(0.001)S(0.131)S(0.868)PVK;SLSS(0.12)S(0.88)PVK 128.28 0.0043687 14229600.0 170675.0 164657.0 181737.0 192194.0 197394.0 139627.0 158878.0 159794.0 130814.0 181570.0 True False 161189.56676615882 177285.66244429816 170044.2392802847 166016.84564685755 172595.6009952501 158859.3518422916 166266.1418107844 160258.9740846794 156980.45524854955 176327.60232448473 0.9141482368116801 1.0054334097848752 0.9643654030261403 0.9415249992530781 0.9788348433255115 0.9009329778666905 0.9429388230710196 0.908870602061297 0.8902772633388853 1.0 17.42789880626814 -6.755545761126998 24.998718129560014 0.923804275988332 0.9624580274082528 0.16054659040317387 0.035962262484631774 218.692642579811 927618.9593189759 0.01139718416487704 0.011105111307272332 1.7557158866201612e-07 6.755545761126998 0.03865375141992078 SLSSS(ph)PVKK ddPTM_A459_Selumetinib_30min_R1 1 SLSSSPVKK 9 1 Q9H3Q1;Q9H3Q1-2 Q9H3Q1 CDC42EP4 Cdc42 effector protein 4 1 SLS(0.098)S(0.098)S(0.804)PVKK 78.488 0.026362 167180000.0 10861.0 13622.0 14352.0 16994.0 15574.0 15988.0 16258.0 16343.0 9314.3 14329.0 True False 11114.040168172856 12027.12990730401 12403.077229892928 14026.316916888496 14165.334449813028 15827.17523594253 15031.645970609115 15909.530550454392 15805.686810443905 16168.266726279498 0.6873983684415826 0.7438725567135414 0.7671247289440911 0.8675213709884232 0.8761195426587716 0.9789036452631891 0.9297005192385311 0.9839972842973599 0.9775745958441999 1.0 13.980877406571883 -5.732875426823629 0.5997285179671992 0.9898838346549804 0.6376053701479236 0.9591326952099558 0.02172700118357008 0.24512363525239492 0.1400772280426886 0.012681078967289695 0.05228043741063477 1.8497991398992244e-06 5.732875426823629 -0.3522784645070568 SLSSSS(ph)IGSNSTYLTSK ddPTM_A459_Selumetinib_30min_R1 1 SLSSSSIGSNSTYLTSK 17 0 Q86SQ4-2;Q86SQ4;Q86SQ4-4;Q86SQ4-3 Q86SQ4-2 GPR126 G-protein coupled receptor 126 1 SLS(0.001)S(0.005)S(0.016)S(0.765)IGS(0.156)NS(0.043)T(0.012)Y(0.001)LTSK 106.31 0.0042893 0.0 888.26 881.26 1163.2 920.91 872.38 1037.0 818.3 901.03 470.32 1074.3 True False 908.954729746913 778.0816695133414 1005.2438290002411 760.0903561216779 793.4733830311982 1026.5687215206653 756.5749721828902 877.1317574420804 798.0986891863017 1212.196869568154 0.749840848929703 0.6418773130395342 0.8292743977786051 0.6270354058845744 0.6545746841549539 0.8468663360650166 0.6241353951461865 0.7235885353792072 0.6583903235706465 1.0 10.243408306645188 -10.921467177885877 3.5483026301723073 1.0021566250989395 0.706297111330436 0.5674352405853234 0.07696188420033279 37911000.56729704 43513222.24617395 794595.3309616508 0.017927920152345216 1.1982096753160015e-11 10.921467177885877 -0.2958595137685035 SLSSSSIGS(ph)NSTYLTSK ddPTM_A459_Selumetinib_30min_R2 1 SLSSSSIGSNSTYLTSK 17 0 Q86SQ4-2;Q86SQ4;Q86SQ4-4;Q86SQ4-3 Q86SQ4-2 GPR126 G-protein coupled receptor 126 1 SLSS(0.01)S(0.069)S(0.146)IGS(0.561)NS(0.1)T(0.1)Y(0.013)LT(0.001)SK 98.105 0.0053233 2895400.0 24552.0 8484.4 14994.0 18520.0 13080.0 11826.0 32255.0 19547.0 16728.0 14076.0 True False 23187.498129443255 9135.126198354154 14029.30236423285 15997.544051218027 11436.773463316364 13454.924154260556 33754.92141206997 19603.87853381996 20074.067419372022 13669.589306159873 1.696283451544105 0.6682809551738053 1.0263148401913496 1.1703017327674297 0.8366581619363397 0.9842961520575763 2.4693442250572315 1.434123446926525 1.4685201559293464 1.0 13.738682278318798 SLST(ph)NGENMGLAVQYLDPR ddPTM_A459_Selumetinib_30min_R2 1 SLSTNGENMGLAVQYLDPR 19 0 J3KRN4;J3QRB6;Q99759;Q99759-2 J3KRN4 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1 S(0.007)LS(0.158)T(0.836)NGENMGLAVQYLDPR 100.46 0.005710100000000001 0.0 3552.8 2890.1 3202.0 3823.4 4362.7 3399.9 3377.4 3410.7 2640.6 3047.7 True False 3355.3495989852568 3111.761376863815 2995.9868060740005 3302.6463242671152 3814.61862296715 3868.2053637806903 3534.4557921911387 3420.6245723282186 3168.793784528561 2959.7049821244277 1.1336770452630862 1.0513755241342477 1.0122585947480247 1.1158701101001391 1.288850965216499 1.3069563984056802 1.1941919257284097 1.1557315992599202 1.0706451499953393 1.0 11.531237662530534 -6.005744431998057 24.1247907806537 1.1868513272251915 1.0642864486366996 0.19589341013676032 0.09053033453143593 226.4105583029919 950867.1208863985 0.026589155869318967 0.03802929894182718 9.86860049436408e-07 6.005744431998057 -0.12256487858849185 SLSVLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 SLSVLSPR 8 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 SLSVLS(1)PR;SLSVLS(1)PR;SLS(0.01)VLS(0.99)PR;SLSVLS(1)PR 104.42 0.014616999999999996 42622300.0 14473.1 16920.3 19143.300000000003 19508.0 18027.0 14911.0 15415.699999999999 15026.099999999999 9031.4 12248.099999999999 True False 14810.295070249771 14939.263409965944 16543.745006619934 16101.294010513178 16396.461032925345 14761.008878104762 14252.881337748735 14627.559016348454 15325.626172642398 13820.262941597039 1.0716362729737128 1.0809681026401365 1.1970644174088467 1.1650497590787914 1.1864073138271714 1.0680700461693975 1.0313031957481487 1.0584139446668246 1.10892435530401 1.0 13.754497443968052 -6.885895702922789 6.781350218452065 1.0539589006768106 1.1412135910652343 0.47908356937462127 0.04549302990903001 0.2149525125729638 11.963151804477215 0.017213158816631356 0.015184436067141401 1.3004818550173537e-07 6.885895702922789 0.0872546903884237 SLSVLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SLSVLSPR 8 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6 A0A087WVP4 SMTN Smoothelin 1 SLS(0.005)VLS(0.995)PR 91.265 0.027107 14347000.0 27280.0 30520.0 34166.0 30951.0 39487.0 25192.0 27914.0 28378.0 20854.0 32163.0 True False 25763.8868104925 32860.78586273263 31967.79675712813 26735.420406546917 34526.29004174108 28661.96932979299 29212.056310541666 28460.57528176921 25025.38270944429 31234.370620490194 0.8248569219957651 1.0520713307146161 1.0234813803533727 0.8559615537445182 1.1053941333170754 0.9176419681397495 0.9352535597876955 0.9111941337821824 0.8012129654703937 1.0 14.93084683912005 -7.348065195703487 2.0765466994815696 0.895761306636215 0.9732331436898851 0.07523165811748334 0.09190942336617887 0.737028853683074 6.2023022037539715 0.04672411191641515 0.027970314022321557 4.486780299348909e-08 7.348065195703487 0.07747183705367011 SLSVS(ph)SDFLGK ddPTM_A459_Selumetinib_30min_R2 2 SLSVSSDFLGK 11 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 SLS(0.001)VS(0.993)S(0.006)DFLGK;SLSVS(0.815)S(0.185)DFLGK 149.41 0.00063169 7789400.0 37218.0 37476.0 33161.0 41797.0 37689.0 31359.0 34100.0 35957.0 26895.0 33284.0 True False 35149.57255545855 40350.28869566736 31027.45736296686 36104.176496153326 32954.17087606501 35678.41760134085 35685.71756786811 36061.62891699818 32274.751509087197 32323.004437782405 1.0874475676639814 1.2483458576177977 0.959918729791678 1.1169808352948498 1.0195268493526806 1.1038088266212127 1.1040346709278988 1.115664510284375 0.998507164493694 1.0 14.98027368302396 -1.5234957099712751 0.013149912662853848 0.09335664782351275 2.2401824191894337 0.1625639433482181 0.07268574513126867 13807.600967612882 14.081601208416107 945.2759591531997 1393.865679565004 0.029957411846811662 1.5234957099712751 2.146825771365921 SLSYS(ph)PVER ddPTM_A459_Selumetinib_30min_R1 2 SLSYSPVER 9 0 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.003)LS(0.079)YS(0.918)PVER;SLS(0.041)YS(0.959)PVER 169.99 0.00066331 185199000.0 7213.200000000001 8326.4 9231.1 8947.2 8765.1 7429.8 7846.4 6878.200000000001 4213.4 5639.3 True False 7381.2535255560715 7351.541217161654 7977.567322802715 7384.739479744899 7972.298252604098 7355.062957718646 7254.539730827121 6695.767792457648 7149.832065439624 6363.159086433665 1.1599982689876474 1.1553288417439118 1.2537117514177807 1.160546102876676 1.2528836925672875 1.1558822996268838 1.1400846077059257 1.0522710027371638 1.1236293118434137 1.0 12.63552747576921 -7.86384061673455 0.8437438110791814 1.023291867866595 1.197186904253156 0.6517023156936466 0.0434691636828734 0.35998262928327945 0.48208276893431834 0.03914623401820033 0.016461291464109108 1.3682308653441733e-08 7.86384061673455 0.173895036386561 SLSYS(ph)PVER ddPTM_A459_Selumetinib_30min_R2 4 SLSYSPVER 9 0 Q9UQ35;Q9UQ35-2;I3L4U6 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SLS(0.242)YS(0.758)PVER;SLS(0.019)YS(0.981)PVER;SLS(0.077)YS(0.923)PVER;S(0.008)LS(0.061)YS(0.931)PVER 181.87 0.0010799000000000002 238796000.0 704540.0 700160.0 687600.0 738720.0 792830.0 610300.0 548890.0 604500.0 604620.0 692170.0 True False 665384.4872970819 753860.0206307621 643360.5646022735 638105.061636922 693227.6074098718 694363.2852481996 574414.4726049018 606258.9949196378 725560.894494304 672185.2536263628 0.9898826011243306 1.1215063355879549 0.9571179390375149 0.9492994054755262 1.031304396622788 1.0329939276444833 0.854547863860448 0.9019224858756417 1.0794061467132545 1.0 19.358499367642864 SLT(ph)AHSLLPLAEK ddPTM_A459_Selumetinib_30min_R1 2 SLTAHSLLPLAEK 13 0 F2Z2E2;Q86VI3 F2Z2E2 IQGAP3 Ras GTPase-activating-like protein IQGAP3 1 S(0.404)LT(0.593)AHS(0.003)LLPLAEK;S(0.164)LT(0.835)AHS(0.001)LLPLAEK 130.95 0.0021323 33771000.0 23840.8 23898.6 26216.4 25971.7 21161.4 24421.2 21578.8 20647.5 10704.9 16231.9 True False 24396.244253878598 21100.540801842286 22656.356876377173 21436.230144189303 19247.355106348605 24175.544900675486 19951.09374280846 20099.861227467853 18165.433445038372 18315.422477095137 1.3320055425632689 1.1520641048946676 1.2370097880466975 1.170392338533112 1.050882398722657 1.3199556237869419 1.0893056803772263 1.0974282057978348 0.9918107795632704 1.0 14.160771359251687 -7.8183351248247 1.5149724068004913 0.9969072089823505 1.2000107441080456 0.510303455605905 0.08083863611265661 0.3507406622642824 1.4891687842210968 0.06467017525149843 0.024163559938894998 1.5193746466101577e-08 7.8183351248247 0.20310353512569512 SLT(ph)NDWEDHLAVK ddPTM_A459_Selumetinib_30min_R1 1 SLTNDWEDHLAVK 13 0 P07900;P07900-2;P08238 P07900;P08238 HSP90AA1;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta 1 S(0.034)LT(0.966)NDWEDHLAVK 147.09 0.00078995 6951800.0 2404.3 3166.4 3129.2 3635.7 2885.4 2482.8 3090.4 3201.4 1277.1 2186.0 True False 2460.3155120465913 2795.676415980576 2704.2718274652275 3000.793245541456 2624.4160794587447 2457.825286202032 2857.2886399046865 3116.4884723872406 2167.145424306485 2466.594393443158 0.9974544329569314 1.1334155398277896 1.0963585397963593 1.2165734477943906 1.0639836393186968 0.9964448523582004 1.1583942003193124 1.2634782924471362 0.8785982122019391 1.0 11.268304783162774 -8.280594332552395 24.995595426093633 0.9392990898011012 1.1147826422384624 0.40634044193900476 0.0853111162953711 951.0802196376599 1241067.1170371214 0.08205844653196356 0.02133148429452419 5.240897517755588e-09 8.280594332552395 0.17548355243736113 SLT(ph)PALCR ddPTM_A459_Selumetinib_30min_R2 2 SLTPALCR 8 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 S(0.112)LT(0.888)PALCR;S(0.001)LT(0.999)PALCR 111.61 0.026956 5042500.0 38189.0 37245.0 37899.0 43714.0 49105.0 41166.0 39877.0 37861.0 31942.0 42403.0 True False 36066.60826267953 40101.571738449464 35460.61960131122 37760.07778914389 42935.990895730145 46836.24283225861 41731.35951477643 37971.16924177402 38331.292534049586 41178.715213774994 0.8758555985888221 0.9738422272347825 0.8611395333055225 0.9169804738471415 1.0426743688537254 1.1373896098776555 1.0134206300058766 0.9221067011112577 0.9308520757643042 1.0 15.329611197775304 -6.20970957443711 7.662114679686987 1.010557803496346 0.9080428614804634 0.3839684048085845 0.06248816189778826 0.35838819507697023 47.773375167766645 0.020656083520632786 0.02662961088439442 6.170074750741574e-07 6.20970957443711 -0.10251494201588263 SLT(ph)PAVPVESKPDKPSGK ddPTM_A459_Selumetinib_30min_R2 2 SLTPAVPVESKPDKPSGK 18 2 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;H0YA91;B7Z574;E7EVY3;E7ES10;H0Y944;E7EQK6;P20810-5;F8W7E0;E9PCH5;P20810-2;E9PSG1;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 S(0.06)LT(0.94)PAVPVESKPDKPSGK;S(0.057)LT(0.943)PAVPVESKPDKPSGK 72.793 0.024714 19018300.0 151507.0 140898.0 160143.0 166443.0 140700.0 116561.0 138745.0 136778.0 117119.0 144879.0 True False 143086.84747057492 151704.42354152343 149839.57373051494 143773.17626980986 123024.00812604069 132616.21971459212 145196.91741800195 137176.0013351833 140546.07257827782 140695.9668291516 1.016993242203784 1.078242873342201 1.0649884080363619 1.021871340806769 0.8743961244847186 0.9425730012263195 1.0319906155825767 0.9749817597952709 0.9989346229728403 1.0 17.10222144751034 -6.009094732038722 24.206874761439355 0.9688382358172315 1.0538147088845768 0.4474778469890347 0.04193971404893337 269.0151916027658 716026.7775151231 0.012752772820194184 0.01782379075454495 9.79276353949281e-07 6.009094732038722 0.08497647306734535 SLT(ph)PPPSSTESK ddPTM_A459_Selumetinib_30min_R1 4 SLTPPPSSTESK 12 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 S(0.392)LT(0.606)PPPSS(0.001)TESK;S(0.453)LT(0.546)PPPS(0.001)STESK;S(0.009)LT(0.97)PPPS(0.007)S(0.012)T(0.002)ESK;S(0.138)LT(0.861)PPPS(0.001)S(0.001)TESK 147.96 0.0014397 111975000.0 19368.300000000003 20307.6 22813.800000000003 23751.2 19992.3 18383.699999999997 20181.199999999997 17787.5 11336.5 15658.4 True False 19819.543705848686 17929.9767512529 19715.81126723324 19603.498785241973 18183.999994927235 18198.776669064082 18658.915836022665 17315.717718057127 19237.21251479954 17668.308165732084 1.1217567364083536 1.0148100532923874 1.1158856344532362 1.109528914786715 1.029187391591649 1.0300237294004668 1.0560669228201418 0.9800439043530602 1.0887976559131092 1.0 14.108876280346482 -6.275597123756156 24.054607831683448 1.0309246623873491 1.0869028351883268 0.3581160581756466 0.03910823351678982 560.1374874794877 951694.3599119665 0.011627485802633725 0.013249389510300896 5.301550177754688e-07 6.275597123756156 0.05597817280097761 SLT(ph)PPPSSTESK ddPTM_A459_Selumetinib_30min_R2 2 SLTPPPSSTESK 12 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 S(0.002)LT(0.997)PPPSSTESK;S(0.001)LT(0.991)PPPS(0.002)S(0.004)T(0.001)ESK 132.5 0.0043837 47697100.0 166843.0 160756.0 154981.0 161453.0 165262.0 128588.0 137098.0 127688.0 112944.0 136924.0 True False 157570.53398544725 173085.46828799 145009.69119055444 139462.82287804017 144500.31009897476 146299.8297943562 143473.32865453328 128059.55094011356 135535.95591903094 132970.6483487239 1.1850023741495839 1.3016817653927841 1.0905391001046894 1.0488241172765447 1.086708321674221 1.100241531579779 1.0789849522149089 0.9630663047101142 1.0192922844414458 1.0 17.02074829794509 -4.227457905470837 0.34338108635323156 0.9964584638729608 1.557915236046666 0.6525997179121322 0.054312901638042296 6.1013173480803715 0.43079588226110216 0.05354291140779104 1.5293452461448858 5.923004935510132e-05 4.227457905470837 0.5614567721737052 SLT(ph)PSTTVSSILR ddPTM_A459_Selumetinib_30min_R2 1 SLTPSTTVSSILR 13 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1 Q8TDM6-4 DLG5 Disks large homolog 5 1 S(0.003)LT(0.978)PS(0.007)T(0.002)T(0.002)VS(0.007)S(0.001)ILR 96.23 0.033566000000000006 3518000.0 23100.0 18751.0 20686.0 22577.0 20668.0 18400.0 22435.0 18724.0 20172.0 18736.0 True False 21816.1944766267 20189.141406032093 19355.085281213855 19501.97365250266 18071.501065735683 20934.43298143026 23478.27195410912 18778.483740074924 24206.963652772152 18195.042998025816 1.1990185722008893 1.1095956963785487 1.0637559517344315 1.0718289401469756 0.9932101324353266 1.1505569392554702 1.2903663902666536 1.0320659171903255 1.3304153035196804 1.0 14.151257840070349 -6.981807902185326 24.85282479577414 1.1736808801920264 1.0850587590479186 0.10519343793329883 0.1053826085442736 442.61501829826415 604668.8983902223 0.0352127482968188 0.031049013818654582 1.0427785708482282e-07 6.981807902185326 -0.08862212114410783 SLTDPSQESHTEAIS(ph)DAETSSSDISFSGIATR ddPTM_A459_Selumetinib_30min_R1 2 SLTDPSQESHTEAISDAETSSSDISFSGIATR 32 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 SLTDPSQESHTEAIS(0.994)DAET(0.002)S(0.003)S(0.001)S(0.001)DISFSGIATR;SLTDPSQESHT(0.003)EAIS(0.467)DAET(0.465)S(0.044)S(0.017)S(0.004)DISFSGIATR 169.92 9.175899999999999e-29 56876000.0 2588.9 3444.5 3357.8999999999996 3593.8 3892.7 3168.6 3421.8 3390.1000000000004 1613.1399999999999 2357.7200000000003 True False 2649.2163328775173 3041.216338695393 2901.9156236244066 2966.210293981045 3540.6059723120056 3136.7267608586117 3163.690871093016 3300.1835354032587 2737.3807609159526 2660.3563281376046 0.9958125927935805 1.1431612775061646 1.0907996018923927 1.114967293143605 1.3308765953133144 1.1790626419786754 1.1891981677912196 1.2405043266191218 1.0289526752351514 1.0 11.377403777910377 -3.6885030033288917 0.9365471479443022 1.1690369533607678 3.567790680185511e-09 0.16800757661067411 0.09369245653234537 20.942369425764014 3.026993194029914 0.030203521207692107 40.014454712823465 0.00020487878816791356 3.6885030033288917 -1.1690369497929771 SLTDPSQESHTEAIS(ph)DAETSSSDISFSGIATR ddPTM_A459_Selumetinib_30min_R2 1 SLTDPSQESHTEAISDAETSSSDISFSGIATR 32 0 Q5QJE6;J3KP30 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 SLTDPSQESHT(0.001)EAIS(0.827)DAET(0.114)S(0.04)S(0.015)S(0.003)DISFSGIATR 135.15 5.206e-19 11050000.0 89147.0 79366.0 97918.0 98168.0 107430.0 90179.0 88832.0 75128.0 78876.0 92213.0 True False 84192.566623716 85453.11699808772 91618.0624850573 84797.34905075427 93933.68296361442 102600.33868654347 92962.86401726874 75346.61004189008 94653.40397957838 89550.57109185282 0.940167835862922 0.954244243852311 1.0230874171766458 0.9469213654011974 1.0489456607402963 1.1457251186182318 1.0381046472826612 0.8413861477734897 1.056982695090705 1.0 16.45041501230515 -5.17918153661337 4.391269241867504 1.0116298488913893 0.9434630120861066 0.11006835680422988 0.07458569745879721 0.5534048986530979 19.29250701414994 0.02051770541703134 0.05948247089084659 6.619397527310697e-06 5.17918153661337 -0.06816683680528268 SLTEISTDFDRS(ph)SPPLQPPPVNSLTTENR ddPTM_A459_Selumetinib_30min_R1 2 SLTEISTDFDRSSPPLQPPPVNSLTTENR 29 1 J3KRR7;Q9NQC7-2;Q9NQC7 J3KRR7 CYLD Ubiquitin carboxyl-terminal hydrolase CYLD 1 SLTEIS(0.001)T(0.004)DFDRS(0.603)S(0.391)PPLQPPPVNSLTTENR;SLTEIS(0.001)T(0.005)DFDRS(0.519)S(0.474)PPLQPPPVNSLTTENR 113.13 1.5684000000000006e-11 82116000.0 2894.9 3499.7 3616.7 3845.1000000000004 3450.2 3396.7 3228.8 3261.4 1949.89 2660.0 True False 2962.3455375051685 3089.953497033609 3125.572005111048 3173.625466466281 3138.1300191822857 3362.5322819568396 2985.2490164782052 3174.8970774797745 3308.8209156690746 3001.436910594144 0.9869757805166601 1.029491403309871 1.0413585553235336 1.0573687073895721 1.0455425560023124 1.120307500080425 0.9946066185636617 1.0577923748033382 1.1024122825937004 1.0 11.551437627879421 -4.497595311093795 1.1045255770085687 1.056363199885515 0.9140661576103011 0.23279380746904343 0.03658862968877909 4.09317683564311 2.7407434477579757 0.011023813205972755 0.7886750464798108 3.179835758938537e-05 4.497595311093795 -0.1422970422752139 SLTEISTDFDRS(ph)SPPLQPPPVNSLTTENR ddPTM_A459_Selumetinib_30min_R2 1 SLTEISTDFDRSSPPLQPPPVNSLTTENR 29 1 J3KRR7;Q9NQC7-2;Q9NQC7 J3KRR7 CYLD Ubiquitin carboxyl-terminal hydrolase CYLD 1 SLTEIS(0.002)T(0.002)DFDRS(0.498)S(0.498)PPLQPPPVNSLTTENR 79.408 1.9545e-05 24128000.0 36243.0 31024.0 27813.0 37044.0 38028.0 27778.0 25135.0 27114.0 33050.0 34414.0 True False 34228.75915222431 33403.441042117214 26023.54186050474 31998.543295535666 33250.58266536655 31604.167356422255 26303.827304057613 27192.89725103567 39660.923494156224 33420.37840168981 1.0241882584577087 0.9994932026391495 0.7786728668275321 0.957456044061959 0.9949193951581745 0.9456555810518373 0.7870595296050756 0.8136621591831148 1.1867287383003082 1.0 15.028440447932116 -8.262435608294416 24.999940760740525 1.0933643670102828 0.9122192577889362 0.3652793481263994 0.09529133995595654 100.73921961207287 2527818.438713738 0.07917223456993716 0.02494334634943339 5.464675671907961e-09 8.262435608294416 -0.18114510922134663 SLTEISTDFDRSS(ph)PPLQPPPVNSLTTENR ddPTM_A459_Selumetinib_30min_R1 1 SLTEISTDFDRSSPPLQPPPVNSLTTENR 29 1 J3KRR7;Q9NQC7-2;Q9NQC7 J3KRR7 CYLD Ubiquitin carboxyl-terminal hydrolase CYLD 1 SLTEIS(0.003)T(0.003)DFDRS(0.397)S(0.597)PPLQPPPVNSLTTENR 68.657 0.00023952 39905000.0 510.92 565.76 533.8 727.97 465.48 567.78 526.55 525.92 383.36 408.16 True False 522.8234419227401 499.52055618531153 461.31289195351474 600.8437051893211 423.37741618716876 562.0686487029926 486.83190957216294 511.97089317108083 650.5339204934102 460.55131181507727 1.1352121435985978 1.0846143380129625 1.0016536271179775 1.3046183775296132 0.9192839219556175 1.220425681750478 1.0570633436120533 1.111647888165499 1.4125112746494914 1.0 8.847218091318616 -8.043596166136021 24.978329922498244 1.2248636685755265 1.1024256446300984 0.07849590940078965 0.13701351361177116 954.0115048303836 546593.2010260075 0.08409281410513302 0.03178879660075105 9.044901336685813e-09 8.043596166136021 -0.12243802394542813 SLTEISTDFDRSS(ph)PPLQPPPVNSLTTENR ddPTM_A459_Selumetinib_30min_R2 1 SLTEISTDFDRSSPPLQPPPVNSLTTENR 29 1 J3KRR7;Q9NQC7-2;Q9NQC7 J3KRR7 CYLD Ubiquitin carboxyl-terminal hydrolase CYLD 1 SLTEIST(0.001)DFDRS(0.175)S(0.823)PPLQPPPVNSLTTENR 111.27 3.505e-11 25304000.0 32973.0 32504.0 37200.0 39351.0 41734.0 32612.0 27092.0 26626.0 16983.0 35617.0 True False 31140.492661377157 34996.95228316717 34806.59250029758 33991.325915738664 36491.001813306204 37104.006977739315 28351.83168177956 26703.477251828423 20380.07454466734 34588.64466592043 0.9003097103732233 1.01180467234812 1.0063011383210365 0.9827307847430549 1.0549994706574939 1.0727221993262206 0.8196861124689893 0.7720301708768277 0.5892128686021474 1.0 15.078010863278674 -7.39826767769602 4.486750412094215 0.7662301304630993 1.0058928734951202 0.4981553999319106 0.1025400390076801 0.17487184274962425 5.589445868323756 0.0433720632583826 0.02832599737422478 3.9969831949711726e-08 7.39826767769602 0.23966274303202095 SLTNDWEDHLAVK ddPTM_A459_Selumetinib_30min_R1 2 SLTNDWEDHLAVK 13 0 P07900;P07900-2;P08238 P07900;P08238 HSP90AA1;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta 0 ; 147.52 0.00080235 109485000.0 7207.5 10557.3 8787.8 10421.9 8742.0 8742.1 8811.7 7253.6 4501.9 6358.8 False True 7375.420726646344 9321.246408044379 7594.465027930122 8601.910808292356 7951.287643525456 8654.162411191714 8147.026374659635 7061.210964986602 7639.395494233321 7175.013919957152 1.02793120806801 1.2991258988526175 1.0584599713188396 1.1988702606368915 1.1081912498328559 1.2061526998742595 1.1354718562982644 0.9841389917510809 1.0647220450659338 1.0 12.808765915367998 -7.6906450192383575 6.1402692417813585 1.018738504780626 1.1538402799933607 0.3893977576779619 0.0753232721324128 0.1882758874474426 12.29953866793518 0.033217722689261237 0.018733324381751543 2.038707782393826e-08 7.6906450192383575 0.1351017752127346 SLTNDWEDHLAVK ddPTM_A459_Selumetinib_30min_R2 3 SLTNDWEDHLAVK 13 0 P07900;P07900-2;P08238 P07900;P08238 HSP90AA1;HSP90AB1 Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta 0 ;; 149.32 0.00073413 3491000.0 71020.0 73155.0 83400.0 77739.0 94709.0 66543.0 60327.0 66613.0 59266.0 88984.0 False True 67072.99271558561 78765.75326960035 78034.13479905423 67150.81409274516 82810.80871079743 75708.69423278872 63132.32503568272 66806.83280162419 71120.8560303983 86414.80071180234 0.7761748237929447 0.9114845214107252 0.9030181653638473 0.7770753799073896 0.9582942739979878 0.8761079538362992 0.7305730559540624 0.7730947968557874 0.8230170693512318 1.0 16.398990810975256 SLTNPT(ph)PIQQQLR ddPTM_A459_Selumetinib_30min_R2 1 SLTNPTPIQQQLR 13 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.001)LT(0.036)NPT(0.963)PIQQQLR 106.6 0.016812999999999998 0.0 44700.0 34204.0 36997.0 45188.0 40576.0 38747.0 35491.0 31006.0 37041.0 41391.0 True False 42215.75294827764 36827.33681680558 34616.65329928787 39033.316446352066 35478.48012595756 44084.047539754276 37141.40182408235 31096.22232668037 44450.235012013356 40195.93428326675 1.05024932747618 0.9161955673744971 0.8611978777589581 0.9710762330159676 0.882638524481989 1.0967290181411733 0.924008919965421 0.7736161102150443 1.1058390806086484 1.0 15.294761963391379 SLTQPIT(ph)TEEVVIAATLQASAHQK ddPTM_A459_Selumetinib_30min_R1 1 SLTQPITTEEVVIAATLQASAHQK 24 0 O95425-4 O95425-4 SVIL Supervillin 1 S(0.139)LT(0.125)QPIT(0.571)T(0.165)EEVVIAATLQASAHQK 61.111 0.009852799999999998 22969000.0 3283.5 3090.9 3637.3 3986.4 3785.1 3242.1 3883.5 3240.7 1781.5 2672.3 True False 3359.9991614211945 2729.015991079575 3143.3746382587483 3290.250073995781 3442.738373313683 3209.48741759127 3590.564468376213 3154.746108722849 3023.07538438807 3015.3157354062882 1.1143108902220693 0.9050514873235533 1.0424694838251176 1.0911792869188366 1.1417505413740041 1.064395141080912 1.1907756213438174 1.0462407208901372 1.0025734117627108 1.0 11.558093360106088 -4.449739659660231 23.457472402770502 1.060278831036804 3.9217951486015408 0.04934610965770847 0.0749747001023867 2801.6312365056115 1014056.1805431646 0.01895675001338547 54610.49826527198 3.550261479358551e-05 4.449739659660231 2.8615163175647367 SLTQPIT(ph)TEEVVIAATLQASAHQK ddPTM_A459_Selumetinib_30min_R2 1 SLTQPITTEEVVIAATLQASAHQK 24 0 O95425-4 O95425-4 SVIL Supervillin 1 S(0.101)LT(0.378)QPIT(0.494)T(0.028)EEVVIAATLQASAHQK 132.86 1.3927e-07 2654400.0 6147.4 3805.9 7488.7 8302.7 7445.8 8437.8 4094.3 5386.5 6742.7 5662.9 True False 5805.752117991996 4097.800292102692 7006.885195080065 7171.857937043619 6510.392037703442 9600.030359277836 4284.693062701541 5402.173823216924 8091.428406779034 5499.397363018807 1.055706968373171 0.745136243410727 1.2741187320266212 1.3041170629479195 1.18383735670442 1.7456513369690478 0.7791204708200112 0.9823210556749961 1.4713300153923363 1.0 12.425057818023182 -5.273269620690471 24.418901971674515 1.2220191320250988 0.9004216014252043 0.18712009649832162 0.26427124546257563 792.0018660870599 1634780.3760546618 0.06943300539739482 0.14651185275375062 5.330038908322673e-06 5.273269620690471 -0.3215975305998945 SLTQPITTEEVVIAATLQASAHQK ddPTM_A459_Selumetinib_30min_R1 1 SLTQPITTEEVVIAATLQASAHQK 24 0 O95425-4 O95425-4 SVIL Supervillin 0 243.7 5.965699999999999e-45 3303800.0 1439.2 990.04 1266.7 1259.9 1423.5 1639.6 1211.2 1293.7 501.76 920.26 False True 1472.7305598042885 874.1256565428911 1094.689097485045 1039.882116252078 1294.744676339338 1623.1071126376876 1119.8382088572853 1259.3868734701618 851.4500728995558 1038.3843350914908 1.4182904248786918 0.8418132159764071 1.0542234320094912 1.0014424150191512 1.2468838681250518 1.5631082420890696 1.0784428953838345 1.2128330820391264 0.8199758452871263 1.0 10.020124808997476 -8.255212616049484 24.631400916891184 0.9099879173861374 1.167900898256078 0.2217643151312242 0.199577615503193 609.1579699902545 2409694.1483153836 0.1481297142651876 0.05275054480104396 5.5563217175064325e-09 8.255212616049484 0.2579129808699405 SLTS(ph)SLENIFSR ddPTM_A459_Selumetinib_30min_R1 1 SLTSSLENIFSR 12 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 SLT(0.001)S(0.499)S(0.499)LENIFSR 217.2 4.9229e-08 73585000.0 3488.1 4108.6 4189.9 4525.6 4505.1 3610.9 4537.0 4040.6 1871.5 3332.7 True False 3569.3659433388993 3627.5632019636805 3620.9345934732687 3735.2889160333402 4097.614500440008 3574.57762443488 4194.770437240342 3933.4301622814687 3175.7988110481488 3760.4845082470315 0.9491771434002735 0.9646531435000345 0.9628904428491278 0.9932999079883362 1.0896506797072623 0.9505630502121619 1.1154866954087668 1.0459902583444112 0.8445185199097026 1.0 11.876702838217449 -5.867407725845999 4.1959825822126176 1.014655832436777 0.9593958861145179 0.08016742889523698 0.07090744169652903 0.517813906948105 16.38395565334721 0.02026757312565298 0.031356408078516675 1.3570388284785282e-06 5.867407725845999 -0.05525994632225906 SLTS(ph)SLENIFSR ddPTM_A459_Selumetinib_30min_R2 2 SLTSSLENIFSR 12 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 S(0.001)LT(0.117)S(0.844)S(0.038)LENIFSR;SLT(0.001)S(0.787)S(0.212)LENIFSR 249.19 2.5159e-18 25278800.0 66686.0 53902.0 66834.0 72613.0 78222.0 59154.0 59605.0 60231.0 50233.0 61110.0 True False 62979.8590852091 58036.1100777528 62533.97320335718 62722.98413558821 68395.05304644738 67301.92655345255 62376.750605066816 60406.26223822115 60281.0036272905 59345.59551715184 1.061238977153863 0.9779345808566268 1.0537255993207422 1.056910518615661 1.1524874331521384 1.1340677596537252 1.0510763277628399 1.0178727117290913 1.0157620477473903 1.0 15.85685334014354 -7.68396855354766 3.8341546219183797 1.0117540318658955 1.071853488457419 0.2713859670981512 0.044854920259756674 0.3689891010629203 10.501657735522421 0.027247269546435145 0.014321517268461703 2.070291249286823e-08 7.68396855354766 0.06009945659152338 SLTSS(ph)LENIFSR ddPTM_A459_Selumetinib_30min_R1 2 SLTSSLENIFSR 12 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 SLT(0.018)S(0.222)S(0.761)LENIFSR;SLTS(0.045)S(0.955)LENIFSR 228.17 7.710599999999999e-10 66549100.0 4652.4 4712.3 4955.7 6165.1 6017.6 4597.0 5314.5 5009.4 2385.1099999999997 3846.9 True False 4760.79186800547 4160.581725311165 4282.743159711565 5088.481018259933 5473.309142493569 4550.758353742044 4913.622986271502 4876.5344391755625 4047.3574684579435 4340.687086979177 1.0967830144417658 0.9585076376022873 0.9866509780349226 1.1722754753559463 1.2609315144857907 1.0483958558987172 1.1319919837140457 1.1234475882409893 0.9324232287093122 1.0 12.083707709479397 -4.370975398655201 21.523224403282818 1.0771428626767465 37.62825961584965 0.00026001728723157314 0.09897743084104337 8786.408159836763 1249568.8911315314 0.025174626493963844 59056.88671157124 4.256225225578852e-05 4.370975398655201 36.551116753172906 SLTSS(ph)LENIFSR ddPTM_A459_Selumetinib_30min_R2 1 SLTSSLENIFSR 12 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 SLT(0.001)S(0.307)S(0.693)LENIFSR 181.76 0.00010413 14516000.0 12414.0 11753.0 13935.0 17157.0 14468.0 13183.0 12532.0 13363.0 12064.0 11973.0 True False 11724.0795771794 12654.41730814864 13038.437271280822 14820.18700252416 12650.400494438929 14998.838586641039 13114.7628316869 13401.884117636257 14477.13709632377 11627.308380410062 1.0083227513714506 1.0883359152552514 1.1213633323124257 1.2746016978008021 1.0879904514919887 1.2899665250051682 1.1279276684346768 1.152621370240428 1.2450978870324931 1.0 13.50522954380156 -5.079327155751847 1.8932713035781092 1.174697175263143 1.0047243545058206 0.25177411695883845 0.08413976617392863 0.5788391849266689 3.2749934903463265 0.021742295694396754 0.14082687815157846 8.330534057679754e-06 5.079327155751847 -0.16997282075732234 SLTTECHLLDS(ph)PGLNCSNPFTQLER ddPTM_A459_Selumetinib_30min_R1 2 SLTTECHLLDSPGLNCSNPFTQLER 25 0 Q15398-1;Q15398 Q15398-1 DLGAP5 Disks large-associated protein 5 1 SLTTECHLLDS(1)PGLNCSNPFTQLER;SLTTECHLLDS(0.999)PGLNCS(0.001)NPFTQLER 147.23 5.9974e-10 15263200.0 1762.3400000000001 2437.4 2652.5 2445.44 2624.9 2132.8500000000004 2005.56 1966.59 725.15 1643.78 True False 1803.3990930833036 2152.0280748834816 2292.3050691395624 2018.389810594082 2387.4782584637355 2111.3954654728573 1854.2789945143804 1914.429644815402 1230.5265871394945 1854.7751747730972 0.972300641938407 1.160263574881386 1.2358937623909 1.088212651347892 1.2872062829694744 1.1383565481089393 0.9997324849580341 1.032162642056929 0.6634370590441131 1.0 10.857028606873499 -7.728160586078705 1.7316908058733045 0.8496930550809089 1.1527383425256892 0.48895614983017877 0.11799955835285642 0.29569244424678803 1.7072402521344634 0.08405344128712142 0.034411374928754374 1.8699905589864683e-08 7.728160586078705 0.3030452874447803 SLTTECHLLDS(ph)PGLNCSNPFTQLER ddPTM_A459_Selumetinib_30min_R2 2 SLTTECHLLDSPGLNCSNPFTQLER 25 0 Q15398-1;Q15398 Q15398-1 DLGAP5 Disks large-associated protein 5 1 SLTTECHLLDS(1)PGLNCSNPFTQLER;SLTTECHLLDS(1)PGLNCSNPFTQLER 146.45 6.583200000000001e-10 8033400.0 28335.0 28078.0 39575.0 36819.0 44472.0 25818.0 27196.0 30362.0 28833.0 40183.0 True False 26760.254133992126 30231.492315000232 37028.78758600205 31804.188683682318 38885.029775275645 29374.195147530787 28460.66788785164 30450.348393300308 34600.40566133153 39022.8123820277 0.6857592392883706 0.7747133143310708 0.948901048532729 0.8150152882965969 0.9964691779412722 0.7527441861432654 0.7293341035808953 0.7803217281008809 0.8866712455934379 1.0 15.252030136568449 SLTVSDDAES(ph)SEPER ddPTM_A459_Selumetinib_30min_R1 1 SLTVSDDAESSEPER 15 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 SLTVSDDAES(0.738)S(0.262)EPER 203.32 9.9188e-06 4142200.0 1538.2 2344.2 2107.0 2306.1 2147.9 1871.5 2108.1 1764.2 1221.1 1710.0 True False 1574.0370671838232 2069.739974210987 1820.8809729225466 1903.3829258583378 1953.6228242425443 1852.6744091860428 1949.0843197589531 1717.4076850707736 2072.11751438466 1929.4951568105214 0.8157766354727344 1.0726847211331134 0.943708496233017 0.9864668066877413 1.0125046530160284 0.9601860894269026 1.010152481015196 0.8900813661070127 1.0739169295505748 1.0 10.91400770726413 -4.743157024403065 24.969367378821836 0.9891313856520205 0.8157760761639459 0.5041906550958208 0.05291045055232617 959.6157439400306 1310538.1532689664 0.012079185460315901 0.3974530670065123 1.8065208385387946e-05 4.743157024403065 -0.17335530948807465 SLTVSDDAESS(ph)EPER ddPTM_A459_Selumetinib_30min_R1 2 SLTVSDDAESSEPER 15 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 SLTVSDDAES(0.225)S(0.775)EPER;SLTVSDDAES(0.352)S(0.648)EPER 225.21 3.097e-10 35408000.0 4409.0 5920.7 5823.799999999999 5944.8 5662.1 4982.3 5612.700000000001 5003.5 3128.5 4736.8 True False 4511.721121579429 5227.501691541245 5032.959947843539 4906.652277716767 5149.964054724946 4932.182585566455 5189.329520189307 4870.790926341465 5308.836003400546 5344.814420339222 0.8441305472479026 0.9780511128035515 0.9416528904522956 0.9180210746036255 0.9635440353414724 0.9227977246127511 0.9709092050870408 0.9113115149154848 0.9932685376686302 1.0 12.38392414102613 -1.5228787647061568 0.04251212264075843 1.1407187821180227 0.6122602476108674 0.3407055602175654 0.03631235841385302 880.1638459529086 2.854164839816139 9.370215854582003 32.643587423741934 0.029999998658111978 1.5228787647061568 -0.5284585345071553 SLTVSDDAESS(ph)EPER ddPTM_A459_Selumetinib_30min_R2 1 SLTVSDDAESSEPER 15 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 SLTVSDDAES(0.319)S(0.681)EPER 153.41 0.00020807 20700000.0 71409.0 67807.0 73018.0 64798.0 72685.0 56878.0 58669.0 62975.0 48242.0 56404.0 True False 67440.37365287606 73007.57886613061 68320.10137598723 55972.4006172152 63553.66048785544 64712.42821292338 61397.22475041804 63158.2468239275 57891.74799410246 54775.46996480828 1.2312148795109312 1.332851711049416 1.247275494302121 1.0218515816144693 1.160257694341772 1.1814125603029846 1.1208890547148944 1.1530388851890256 1.0568918538041991 1.0 15.741242336911723 -1.5228787452803523 0.14319036987402253 0.9858216249010783 2.058401427876187 0.5560534779934663 0.0663052690465523 59.86338730682398 0.5701946778969458 0.2867473009081818 13.196900414693468 0.029999999999998982 1.5228787452803523 1.0725798029751086 SLTWPPSGSPS(ph)HAGTTPPENGLSEHPCETEQINAK ddPTM_A459_Selumetinib_30min_R1 1 SLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAK 35 0 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6 P23497-5 SP100 Nuclear autoantigen Sp-100 1 S(0.032)LT(0.084)WPPS(0.273)GS(0.273)PS(0.321)HAGT(0.009)T(0.009)PPENGLSEHPCETEQINAK 73.166 8.812e-06 8684000.0 1212.8 1131.4 1217.5 1312.0 1710.8 1169.9 1619.1 1106.1 304.78 781.86 True False 1241.055880302002 998.9351620264094 1052.170187248791 1082.8838292902033 1556.0584420662713 1158.1318681842113 1496.9699834551107 1076.7626348808426 517.1893997495345 882.219346961329 1.4067429880977231 1.1322979545473473 1.1926401193454121 1.2274541847444547 1.7637999522747703 1.312748209584409 1.696822891734575 1.220515780559096 0.5862367465992613 1.0 9.784993588675851 -10.559387557217145 9.851788137852957 1.000000228409251 1.2989315155367394 0.06817804061624155 0.3073257066876315 4.2872976765121805e-10 0.0 0.30381013387095024 0.07368478071076293 2.758115461035171e-11 10.559387557217145 0.2989312871274883 SLTWPPSGSPS(ph)HAGTTPPENGLSEHPCETEQINAK ddPTM_A459_Selumetinib_30min_R2 1 SLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAK 35 0 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6 P23497-5 SP100 Nuclear autoantigen Sp-100 1 S(0.011)LT(0.01)WPPS(0.119)GS(0.119)PS(0.467)HAGT(0.188)T(0.079)PPENGLS(0.006)EHPCET(0.001)EQINAK 44.815 0.010711 4418500.0 3479.8 4940.0 5916.4 7195.6 9175.9 5858.8 4431.9 5156.4 3964.4 6385.5 True False 3286.4066467431026 5318.8821153964345 5535.745265289264 6215.546866897647 8023.141408413201 6665.796519108889 4637.992131643248 5171.404270312026 4757.3907745910155 6201.134023478536 0.5299686532012071 0.8577273278175013 0.8926988586813319 1.002324227046947 1.2938184174114347 1.0749318582490013 0.7479264460472924 0.8339449285779376 0.7671807699331662 1.0 12.598316355071997 -4.602458553946986 1.7142713443774262 0.958326582813313 0.21640153870974327 0.4115202997037286 0.15150625222889513 1.801791711228272 3.6590635902711277 0.04721900876137056 2.5398166621741716 2.4977067415875157e-05 4.602458553946986 -0.7419250441035696 SLVESVSS(ph)SPNK ddPTM_A459_Selumetinib_30min_R2 1 SLVESVSSSPNK 12 0 Q9H2U2-4;Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U2-2 Q9H2U2-4 PPA2 Inorganic pyrophosphatase 2, mitochondrial 1 SLVES(0.011)VS(0.105)S(0.693)S(0.191)PNK 124.21 0.0027344 0.0 35311.0 23958.0 30559.0 24475.0 27220.0 26795.0 38464.0 36755.0 29263.0 20245.0 True False 33348.55598113272 25795.501562888236 28592.867210123466 21141.462778270045 23800.380250112506 30485.768029207815 40252.65221497009 36861.95096488219 35116.417676535384 19660.474247172962 1.6962233749741824 1.312048795903153 1.4543325278247 1.0753282200865546 1.2105699969844235 1.5506120374279095 2.047389686988763 1.8749268456829153 1.7861429604926686 1.0 14.263010502132953 -6.998248707647574 8.403956064597894 1.7572161890172606 1.341869385371107 0.19286981399591518 0.2999472795983464 0.1403394797396891 104.65390246151365 0.10500739779725878 0.08902184594949793 1.0040406411307507e-07 6.998248707647574 -0.4153468036461536 SLVESVSSS(ph)PNK ddPTM_A459_Selumetinib_30min_R2 1 SLVESVSSSPNK 12 0 Q9H2U2-4;Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U2-2 Q9H2U2-4 PPA2 Inorganic pyrophosphatase 2, mitochondrial 1 SLVESVSS(0.024)S(0.975)PNK 187.62 0.00011807 4748000.0 57209.0 38546.0 48327.0 53041.0 50533.0 43441.0 67739.0 65422.0 52311.0 30570.0 True False 54029.55280577222 41502.35425507509 45217.693434459135 45816.72429917143 44184.59276924815 49424.60343186477 70888.99772228199 65612.36718880491 62774.6616914616 29687.364669601233 1.8199511275952522 1.3979804107560942 1.5231292483418168 1.5433072220817925 1.4883299094072686 1.6648363363311174 2.3878508082891474 2.2101108643028042 2.114524559188662 1.0 14.857561411343465 -7.051495248104161 9.452535452461102 2.029284844413564 1.546658275378329 0.16975484366211702 0.3645181408966308 0.6474498295202835 115.50156907878224 0.1304945769183289 0.10144777408271544 8.88187694500103e-08 7.051495248104161 -0.48262656903523515 SLVESVSSS(ph)PNKESNEEEQVWHFLGK ddPTM_A459_Selumetinib_30min_R1 1 SLVESVSSSPNKESNEEEQVWHFLGK 26 1 Q9H2U2-4;Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U2-2 Q9H2U2-4 PPA2 Inorganic pyrophosphatase 2, mitochondrial 1 SLVES(0.013)VS(0.159)S(0.144)S(0.516)PNKES(0.169)NEEEQVWHFLGK 64.069 0.00079748 124690000.0 5687.1 7058.5 8001.9 9181.8 6611.2 6209.3 7223.8 6810.5 3894.9 5495.4 True False 5819.59836482975 6232.087538592378 6915.285931290432 7578.370993732308 6013.218127302158 6146.840079593315 6678.902950085256 6629.863416378245 6609.360827759244 6200.788119728966 0.9385255958534706 1.0050476517273388 1.1152269353129738 1.2221625456964582 0.9697506205977238 0.9912998091381311 1.0771054938702191 1.0691968969692893 1.065890448140024 1.0 12.598235878252598 -10.629147523568939 4.881463826086766 0.9999976876169194 1.0533061160363208 0.035875294278776226 0.07723582363127661 2.057668392269285e-06 3.7677628256914285e-07 0.07916779797032168 0.019200178488174402 2.3488348200249677e-11 10.629147523568939 0.05330842841940142 SLVESVSSSPNKES(ph)NEEEQVWHFLGK ddPTM_A459_Selumetinib_30min_R1 1 SLVESVSSSPNKESNEEEQVWHFLGK 26 1 Q9H2U2-4;Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U2-2 Q9H2U2-4 PPA2 Inorganic pyrophosphatase 2, mitochondrial 1 SLVESVS(0.002)S(0.008)S(0.04)PNKES(0.949)NEEEQVWHFLGK 75.797 8.1742e-05 119790000.0 2336.0 3402.9 3365.1 3574.0 2849.6 2804.3 2672.8 2375.1 1554.4 2402.7 True False 2390.424254935256 3004.486886034711 2908.137903171174 2949.8679922890146 2591.8541831377415 2776.091288100676 2471.188544116375 2312.1046325879097 2637.703271115812 2711.109949279905 0.8817142423789099 1.1082128509147073 1.07267427643191 1.0880665290142608 0.9560121985558576 1.0239685368857987 0.9115043618104625 0.8528258447068978 0.9729237546475789 1.0 11.404667907636433 -6.946813756918056 1.667180605231346 0.9243249317647451 1.038616688322123 0.22762696930210213 0.07338670943401868 0.45775842232833835 2.5925102641629465 0.03390109841464676 0.02668702597389522 1.1302805208695991e-07 6.946813756918056 0.114291756557378 SLVGS(ph)WLK ddPTM_A459_Selumetinib_30min_R2 2 SLVGSWLK 8 0 B0QY16;Q6ICG6-3;Q6ICG6;Q6ICG6-2 B0QY16 KIAA0930 Uncharacterized protein KIAA0930 1 SLVGS(1)WLK;S(0.203)LVGS(0.797)WLK 82.171 0.041961 5223700.0 45445.0 49659.0 51245.0 49952.0 53798.0 40317.0 36379.0 49272.0 38898.0 51740.0 True False 42919.34883074897 53467.6856211481 47947.952491337324 43148.45142799365 47039.41427977779 45870.300788713255 38070.69558362095 49415.373362581304 46678.68690092859 50246.131763335594 0.8541821494419407 1.0641154601310674 0.9542615681775678 0.8587417561062661 0.9361798138280222 0.9129120825612418 0.7576841091556622 0.983466221744845 0.9290006068684046 1.0 15.616724913141237 -4.4725508834635725 16.82596513239249 0.9267834120190369 0.3439932138589603 0.07829509997458695 0.07854846508871317 678757.331143495 5814708.542566227 0.019905689806799253 13072899.796083415 3.368597457609088e-05 4.4725508834635725 -0.5827901981600766 SLVGT(ph)PYWMAPELISR ddPTM_A459_Selumetinib_30min_R1 1 SLVGTPYWMAPELISR 16 0 O96013;O96013-2;O96013-4;O96013-3;M0R1R1 O96013 PAK4 Serine/threonine-protein kinase PAK 4 1 S(0.047)LVGT(0.934)PY(0.019)WMAPELISR 118.52 0.017886000000000003 126390000.0 2035.6 2214.2 2117.0 2113.5 2431.4 2035.3 2395.1 2179.8 1299.7 2169.0 True False 2083.025519411903 1954.9604346463464 1829.5230278486147 1744.4169003085697 2211.480299298536 2014.8267299045413 2214.435678693928 2121.9846230117178 2205.495973667793 2447.412277849133 0.851113454919224 0.7987867235692838 0.7475336478480284 0.7127597242592986 0.9035994136803377 0.8232477822147881 0.9048069664176268 0.8670319431741138 0.9011542491754009 1.0 11.257041435163142 -7.983247959735782 0.429599024419156 0.9987337756117953 0.7778472419681749 0.6081527403556519 0.05005759758087928 0.7214122381328671 0.3631422929458704 0.061986840526884274 0.044196072010691166 1.0393265945487338e-08 7.983247959735782 -0.22088653364362043 SLVHEVGKPPQDVT(ph)DDSPPSK ddPTM_A459_Selumetinib_30min_R1 1 SLVHEVGKPPQDVTDDSPPSK 21 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 SLVHEVGKPPQDVT(0.642)DDS(0.338)PPS(0.02)K 56.347 0.017161000000000003 25436000.0 3853.2 4289.1 4659.6 4468.2 5542.6 3912.1 4258.4 4013.3 1336.0 2773.7 True False 3942.972062977963 3786.9301780515057 4026.8519133506898 3687.912748501894 5041.272808625512 3872.7478259025997 3937.185459542491 3906.8542469643653 2267.094422420691 3129.73141312593 1.2598435911916737 1.2099856755021592 1.2866445652372223 1.1783479991397923 1.6107685111516845 1.237405807303623 1.25799467744425 1.24830336257585 0.7243734759195679 1.0 11.611823138121089 -8.190376277102338 6.370486172116843 0.8645816097965094 1.290179728489768 0.6348233477025421 0.12871494208122644 0.1308282834696662 9.373867078719325 0.08876457560688196 0.032548433545791226 6.450950699894251e-09 8.190376277102338 0.4255981186932586 SLVHEVGKPPQDVTDDS(ph)PPSK ddPTM_A459_Selumetinib_30min_R2 4 SLVHEVGKPPQDVTDDSPPSK 21 1 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 SLVHEVGKPPQDVTDDS(0.969)PPS(0.031)K;SLVHEVGKPPQDVT(0.004)DDS(0.982)PPS(0.014)K;SLVHEVGKPPQDVT(0.055)DDS(0.875)PPS(0.07)K;SLVHEVGKPPQDVT(0.096)DDS(0.699)PPS(0.205)K 95.834 0.00017347 46181000.0 128191.7 127029.1 176903.0 243312.0 239090.0 178005.9 148709.1 161422.0 155552.6 221536.0 True False 121067.31850603409 136771.82350706562 165521.2535774228 210172.48586338898 209053.37670828032 202524.59694832467 155624.36781149148 161891.7112951493 186667.46650278612 215139.68006034623 0.5627382102273042 0.6357349953699913 0.7693664577868408 0.9769117710151658 0.9717099916186605 0.9413632896149932 0.723364317395281 0.75249582619877 0.8676570795793054 1.0 17.71491411238585 -5.341447208357701 2.6657785745991016 0.8784013799122434 0.5839309980340193 0.6233594281769292 0.08970120224008489 0.20755068713810085 2.8262726167941223 0.027448878251617164 0.07653953824482035 4.5556756033928725e-06 5.341447208357701 -0.29447038187822416 SLY(ph)GDVDSPLPTGEAGGPPSTR ddPTM_A459_Selumetinib_30min_R1 1 SLYGDVDSPLPTGEAGGPPSTR 22 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 S(0.2)LY(0.774)GDVDS(0.022)PLPT(0.004)GEAGGPPSTR 163.62 1.6562e-08 13589000.0 1206.2 1069.6 1157.9 1248.6 1289.2 1025.1 963.31 1100.0 812.48 819.29 True False 1234.3021131433666 944.3707347564499 1000.6635398894243 1030.5554491248083 1172.592087626747 1014.7884247163297 890.64675113467 1070.8244266964346 1378.719218808655 924.4538520604044 1.3351689869563295 1.0215444855918498 1.0824375253120155 1.1147721942289783 1.2684160328969336 1.0977166923525596 0.9634301908630855 1.1583319430275534 1.491387823995533 1.0 9.852457493108558 -8.018874047737285 24.966554095636745 1.272082579030327 1.1198966862561808 0.08319551402293723 0.15053245527106185 1424.2928885409176 1884040.7565729378 0.09329777298132629 0.036551657584475 9.574717129599233e-09 8.018874047737285 -0.15218589277414618 SLYAS(ph)SPGGVYATR ddPTM_A459_Selumetinib_30min_R1 5 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SLYAS(0.5)S(0.5)PGGVYATR;SLYAS(0.5)S(0.5)PGGVYATR;SLYAS(0.5)S(0.5)PGGVYATR;SLYAS(0.5)S(0.5)PGGVYATR;SLYAS(0.5)S(0.5)PGGVYATR 252.46 1.1525e-27 5532873000.0 15982.699999999999 17483.0 19909.6 20738.0 18194.3 15856.4 16873.5 16707.600000000002 9881.900000000001 14963.5 True False 16355.06581307949 15436.082232373805 17205.985675604537 17116.49760047274 16548.628777464568 15696.899012459282 15600.718310067212 16264.460174066684 16768.862554580126 16884.21098183289 0.9686603555639793 0.9142317783746456 1.0190577276082295 1.013757623550771 0.9801244959134068 0.9296791558307856 0.9239826679999028 0.9632940616275735 0.9931682666500155 1.0 14.043387141708356 -6.627394821226661 21.043793537049282 0.9570776780839583 0.9797118662334933 0.0478615756266586 0.0348521941681855 10.253870975536756 2027.9962459165888 0.01231039651917512 0.012310370730354538 2.3583332752114566e-07 6.627394821226661 0.022634188149534995 SLYAS(ph)SPGGVYATR ddPTM_A459_Selumetinib_30min_R2 4 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SLYAS(0.5)S(0.5)PGGVYATR;SLYAS(0.922)S(0.078)PGGVYATR;S(0.001)LYAS(0.5)S(0.5)PGGVYATR;SLYAS(0.5)S(0.5)PGGVYATR 241.41 1.2543e-19 4845990000.0 891499.0 864564.0 978331.0 1067393.0 993689.0 790330.0 853057.0 897746.0 806714.0 940616.0 True False 841953.0545332581 930873.278788586 915386.248586255 922012.2320443717 868852.9041276277 899190.7835985752 892725.8408003784 900358.2922301481 968079.3414724563 913457.9720661312 0.9217206267616914 1.0190652523214216 1.0021109635901062 1.0093647001173922 0.9511689981339676 0.9843811221710776 0.9773036834755963 0.9856592418736538 1.059796258915753 1.0 19.80097882684008 -8.167730707661088 8.460275630515003 1.0297045595580823 0.9830705675401984 0.2951509645634224 0.029929005429919695 0.37325764169833914 30.192490839455022 0.019636650117521297 0.007377563379056632 6.7962491601078536e-09 8.167730707661088 -0.046633992017883874 SLYASS(ph)PGGVYATR ddPTM_A459_Selumetinib_30min_R1 1 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SLYAS(0.225)S(0.775)PGGVYATR 185.32 7.662399999999999e-05 15434000.0 3893.6 4200.5 4961.5 4974.6 4435.8 3909.7 3961.4 3727.4 2600.8 3441.7 True False 3984.313304373248 3708.7035072405306 4287.755551568684 4105.879494807199 4034.5826732040996 3870.3719677235727 3662.5884086585647 3628.5372436984476 4413.367645083633 3883.4757199969395 1.0259658078604874 0.9549959301003312 1.1041025773613085 1.0572692584802448 1.0389102350837613 0.9966257669113541 0.9431212328170424 0.9343530139802978 1.1364478532357378 1.0 11.923132730729543 -6.772887247844906 8.743018242553779 0.994257213089045 1.0366942944993816 0.06380653800468516 0.06182348721331782 0.4075920023882491 222.81585974184105 0.021742080536830827 0.01989043091190984 1.6869909475440586e-07 6.772887247844906 0.04243708141033653 SLYASS(ph)PGGVYATR ddPTM_A459_Selumetinib_30min_R2 3 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SLYAS(0.022)S(0.978)PGGVYATR;SLYAS(0.293)S(0.707)PGGVYATR;SLYAS(0.102)S(0.898)PGGVYATR 204.18 2.6737e-05 329727500.0 302561.0 260282.0 298336.0 339047.0 291197.0 242426.0 263030.0 290660.0 262423.0 235220.0 True False 285745.8708676471 280244.792461461 279141.3865636773 292868.2137113024 254614.2295257902 275817.98097588075 275261.41618405725 291505.7724786466 314914.9327112551 228428.58742504433 1.2509199224523972 1.2268376546933708 1.2220072352164488 1.2820996575457222 1.1146338223071064 1.2074582436683263 1.205021750066114 1.2761352498154381 1.3786143681100775 1.0 17.801383687114345 SLYASSPGGVYAT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SLYASSPGGVY(0.004)AT(0.996)R 155.47 0.00076732 5574500.0 728.67 1259.4 1291.8 1320.9 1157.9 1033.1 1072.8 1091.2 558.8 852.99 True False 745.6465932549967 1111.9488625208246 1116.3806553494767 1090.2296113638938 1053.1681494438485 1022.7079519797488 991.8778322837643 1062.2578312828628 948.2427868627859 962.4795753262019 0.7747141990023876 1.1552960613672916 1.1599006191597518 1.1327301267607628 1.0942238946596976 1.0625762646787953 1.0305442917555925 1.1036679203533686 0.9852082175784448 1.0 9.910612115520793 -8.272563673784346 23.897902687184605 0.9926040754602221 1.0725410463183538 0.0648839732731955 0.10498337844945013 1202.0203547288586 2582203.8522580806 0.09528909654895815 0.025659316094663265 5.338709947101869e-09 8.272563673784346 0.07993697085813167 SLYASSPGGVYATR ddPTM_A459_Selumetinib_30min_R1 2 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 0 ; 136.81 0.0082015 33396000.0 4006.8999999999996 3867.6 4438.7 5210.2 5361.7 4466.7 4126.8 3984.7999999999997 2755.93 3540.9 False True 4100.252973929828 3414.7795940015408 3835.9489200338435 4300.336377566935 4876.735181685019 4421.7690534391095 3815.51215349426 3879.1101595454093 4676.611924836721 3995.4090062867667 1.0262411101036437 0.8546758513655031 0.9600891708453344 1.0763194383354409 1.2205847196148096 1.106712490881776 0.9549741084055626 0.9708918795151231 1.1704964166317098 1.0 11.964127482718482 -5.708693323670026 4.926516457323029 1.073221348789419 0.9340606923456893 0.2963596771654545 0.08781218864033506 0.2488265749013787 12.639612648096609 0.025671597856533463 0.044500278650773245 1.9557199967251545e-06 5.708693323670026 -0.13916065644372977 SLYASSPGGVYATR ddPTM_A459_Selumetinib_30min_R2 2 SLYASSPGGVYATR 14 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 0 ; 125.97 0.018504 20658600.0 69301.0 60920.0 63260.0 78915.0 78554.0 60098.0 50645.0 54020.0 42539.0 66956.0 False True 65449.527853883395 65592.36811132614 59189.92047228023 68166.64086403203 68685.34423832987 68375.95398467362 53000.09285116364 54177.18925650755 51047.98863896856 65022.80630741974 1.0065626442581725 1.0087594159072986 0.9102947693834936 1.0483497212001067 1.0563269741634052 1.0515687935922144 0.815100052750504 0.8332028765471077 0.7850782139057491 1.0 15.988658201933132 -7.263508644394641 24.999287217449076 0.844445519563486 1.012241721830072 0.5651085779156131 0.0662877881714966 130.18448904413094 1572774.275891344 0.02653222861215555 0.018891550380531242 5.4511904528383455e-08 7.263508644394641 0.1677962022665861 SLYGDVDS(ph)PLPTGEAGGPPSTR ddPTM_A459_Selumetinib_30min_R1 2 SLYGDVDSPLPTGEAGGPPSTR 22 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 S(0.036)LY(0.013)GDVDS(0.944)PLPT(0.006)GEAGGPPSTR;SLYGDVDS(1)PLPTGEAGGPPSTR 257.88 6.9569e-54 13116000.0 3561.9500000000003 3553.0899999999997 4480.530000000001 4043.77 4196.5599999999995 3314.71 3747.48 3349.5899999999997 1905.75 2943.56 True False 3644.936504651812 3137.092571013271 3872.09863578959 3337.601480464057 3816.981888962844 3281.3670269158793 3464.804566486542 3260.747992198282 3233.9185595271197 3321.3945987024413 1.0974114626656428 0.9445106499055634 1.1658050619165488 1.004879541192711 1.1492106028154596 0.987948564797992 1.0431776362375391 0.9817406198806213 0.9736628586047874 1.0 11.697573417250613 -7.322950137412408 1.5264175210700412 0.985686958344403 1.0639857163974613 0.21196559024266104 0.06477813253709692 0.6414136879365347 2.9023265558107054 0.03685077890226863 0.020896398222751942 4.7538980366827497e-08 7.322950137412408 0.0782987580530583 SLYGDVDS(ph)PLPTGEAGGPPSTR ddPTM_A459_Selumetinib_30min_R2 4 SLYGDVDSPLPTGEAGGPPSTR 22 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;J3QL92 Q9Y4B5 MTCL1 Microtubule cross-linking factor 1 1 SLYGDVDS(1)PLPTGEAGGPPSTR;SLYGDVDS(1)PLPTGEAGGPPSTR;SLYGDVDS(0.999)PLPT(0.001)GEAGGPPSTR;SLYGDVDS(1)PLPTGEAGGPPSTR 247.18 2.593e-44 41994800.0 140586.0 136450.0 140337.0 143298.0 159149.0 106398.0 121782.0 106433.0 112193.0 143176.0 True False 132772.79293034822 146915.2762440982 131307.8702073725 123780.56519716227 139155.27980988807 121053.35871512046 127445.10430645484 106742.70240906821 134634.7349343382 139042.13686407686 0.9549104748019132 1.0566241253017987 0.9443746562650635 0.8902377940161131 1.0008137313505316 0.8706235494169536 0.9165933952168838 0.7677003879292825 0.9683016815683205 1.0 17.08516263387896 -5.696969396528875 0.9751400369833015 0.8988297030580054 1.011372364351951 0.14897429796366102 0.07108565495336028 1.0653914817507935 1.8376887948573914 0.02740407128267562 0.0932173782052073 2.009234392533949e-06 5.696969396528875 0.11254266129394563 SLYYYIQQDTK ddPTM_A459_Selumetinib_30min_R1 2 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 ; 147.62 0.0091865 25098000.0 2743.6 3880.8 3899.7 4332.200000000001 3483.0 3793.5 3396.0 3115.3 2142.5 2907.5 False True 2807.520541883718 3426.434131865028 3370.142159518773 3575.6625954657147 3167.9632649735936 3755.340834222415 3139.8369858647143 3032.672124079457 3635.6660179912656 3280.7059464482995 0.8557672000208207 1.0444197644639546 1.027261270754027 1.0899064572784207 0.9656346276334942 1.1446746204998826 0.9570613877369625 0.9243962042262993 1.108196247191019 1.0 11.67979057385145 -4.758099559918547 24.99574872700108 1.027924578742157 0.8557669604943995 0.377298462243848 0.06677420069295088 101.10149328955431 756538.2833591304 0.01612404526404774 0.11323271534683789 1.7454219774701932e-05 4.758099559918547 -0.17215761824775744 SLYYYIQQDTK ddPTM_A459_Selumetinib_30min_R2 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 125.97 0.039978 0.0 17125.0 16896.0 14362.0 14029.0 19061.0 13180.0 12542.0 14931.0 12663.0 16999.0 False True 16173.261056806605 18191.868870797214 13437.96455616327 12118.225998625136 16666.386772497954 14995.425363872335 13125.227851501522 14974.44673803989 15195.953833782169 16508.194701293804 0.9797110677122709 1.1019902054687698 0.8140178135353644 0.7340733628296369 1.0095826390508802 0.9083625214752945 0.7950734825336688 0.9070917207480168 0.920509729182635 1.0 14.01089473857128 -5.260548903241678 24.999970627930654 0.8792970541712448 1.0408506404431943 0.33666078615058115 0.08647564956427808 83.46179217260199 2343094.4584693164 0.02246677562366245 0.05278348653306319 5.4884674985635426e-06 5.260548903241678 0.1615535862719495 SMDAMS(ph)SPTKTETVK ddPTM_A459_Selumetinib_30min_R1 1 SMDAMSSPTKTETVK 15 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 SMDAMS(0.965)S(0.035)PTKTETVK 162.93 0.00051081 3236500.0 1444.9 1572.4 1939.6 2005.0 1576.5 1786.1 1511.7 1688.4 947.08 1462.5 True False 1478.5633587140208 1388.302677011072 1676.212973460168 1654.864388511325 1433.9058533536822 1768.1334556490463 1397.6712519233486 1643.6181473038725 1607.125588013615 1650.2261209563671 0.8959762180089227 0.84128027024957 1.0157474495002785 1.0028106860605683 0.8689147718269546 1.0714491991099664 0.8469574164256631 0.995995716242411 0.9738820441663026 1.0 10.688448006848999 -5.254347693876873 24.98711003192682 0.9683357017533731 0.8686282383964314 0.2880081432008911 0.0647922023556607 676.1143914219305 2382232.07430227 0.01566128914588001 0.03954312304691143 5.567398474703487e-06 5.254347693876873 -0.0997074633569417 SMDAMS(ph)SPTKTETVK ddPTM_A459_Selumetinib_30min_R2 1 SMDAMSSPTKTETVK 15 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 S(0.011)MDAMS(0.732)S(0.253)PT(0.004)KT(0.001)ETVK 99.927 0.019701 0.0 15831.0 16287.0 15087.0 16859.0 14051.0 12469.0 12905.0 11344.0 8739.2 13962.0 True False 14951.176396514173 17536.160529040833 14116.318845483585 14562.775116602845 12285.787762466227 14186.491567687708 13505.108070772385 11377.009161899705 10487.28419364993 13558.880782367441 1.1026851431540967 1.2933339270779354 1.0411123950467254 1.074039616569305 0.9061063342664094 1.0462878017289183 0.9960341334614443 0.8390817313398656 0.7734623795267859 1.0 13.726950475695638 -5.954382619332303 0.6075046699043806 0.8851192669355957 1.2346253382594408 0.5542235499218424 0.0923766839332279 0.8737551053390578 0.5888911202539832 0.060802661206386825 0.18034850521658585 1.1107527078707288e-06 5.954382619332303 0.34950607132384504 SMDAMSS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 SMDAMSSPTK 10 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 SMDAMS(0.398)S(0.524)PT(0.078)K;SMDAMS(0.145)S(0.823)PT(0.032)K 120.77 0.0049847 18060400.0 12070.4 15260.2 10095.6 10635.599999999999 10139.3 10734.9 11672.0 10484.6 6665.8 11954.8 True False 12351.616835090115 13473.528689725492 8724.67297116131 8778.292114938178 9222.202105238808 10626.91665250934 10791.57164281889 10206.514349219493 11311.37574923042 13489.315029613097 0.9156593057523386 0.9988297152336535 0.6467839880681883 0.6507589225744369 0.6836671902904858 0.7878025406909148 0.8000088676947754 0.7566369624264189 0.8385433748413876 1.0 13.719529471462778 -9.777153457590698 10.496747736087016 0.9999998999213682 0.7811883051095092 0.2628193535713488 0.1069239354204337 0.0 0.0 0.11341602587277591 0.027507426724190622 1.670500240154856e-10 9.777153457590698 -0.21881159481185897 SMDAMSS(ph)PTKTETVK ddPTM_A459_Selumetinib_30min_R1 1 SMDAMSSPTKTETVK 15 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 SMDAMS(0.172)S(0.647)PT(0.176)KT(0.004)ETVK 143.93 0.001571 0.0 1310.1 1593.9 1749.8 1802.2 1291.2 1532.1 1412.0 1289.2 666.1 1156.3 True False 1340.6227809891593 1407.2854470159934 1512.186770963396 1487.4796014838441 1174.411187979875 1516.688465035498 1305.4917031922785 1255.0062280882216 1130.323049980855 1304.722368315792 1.0275157485953963 1.0786091211363193 1.1590103823508526 1.1400736567458143 0.9001234412006518 1.1624606903868167 1.0005896540867 0.961895234239184 0.8663322385128867 1.0 10.34952713324562 -7.599027094746554 3.0470383986534966 0.9338246557674948 1.0769644946975594 0.37206419291945636 0.07873835183579309 0.27204216453493213 5.086265654733427 0.0422424777296443 0.022424347304952328 2.5175198599322386e-08 7.599027094746554 0.14313983893006454 SMDAMSS(ph)PTKTETVK ddPTM_A459_Selumetinib_30min_R2 2 SMDAMSSPTKTETVK 15 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 SMDAMS(0.241)S(0.757)PT(0.002)KTETVK;SMDAMS(0.071)S(0.927)PT(0.001)KTETVK 83.404 0.012951 215280000.0 190158.0 155117.0 172145.0 176070.0 166519.0 130261.0 148946.0 141181.0 104354.0 149036.0 True False 179589.779622787 167013.97512023285 161069.3781173041 152088.9622623085 145599.3945212522 148203.27035837437 155872.2841309 141591.81333622723 125227.71589437735 144732.94343796818 1.2408355372096629 1.1539458201637018 1.1128729527036645 1.0508247718149466 1.0059865505578927 1.023977450039863 1.076964790657395 0.9782970619740956 0.8652329795811092 1.0 17.143033813204866 -1.5228836957591465 0.30522094732326055 0.9566037588813424 3.541495419256011 0.7728636415353702 0.04676646011513657 26.63566485832835 0.3800590004804003 0.04912535716279516 37.81425110706571 0.029999658034987758 1.5228836957591465 2.5848916603746686 SMDAMSSPT(ph)KTETVK ddPTM_A459_Selumetinib_30min_R1 1 SMDAMSSPTKTETVK 15 1 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 SMDAMS(0.176)S(0.176)PT(0.62)KT(0.028)ETVK 246.77 7.889100000000001e-27 38813000.0 4126.0 5059.2 5769.1 6594.2 4261.9 3698.4 4104.3 4770.3 2402.8 3529.9 True False 4222.1277722015675 4466.866512041729 4985.687907397944 5442.646758464523 3876.411897499559 3661.197453878522 3794.709346609111 4643.776147881821 4077.3761064314644 3982.9970491376957 1.0600378860726605 1.121483761332133 1.251742807210296 1.3664701960155448 0.9732399621884701 0.9192066699299106 0.9527271297955522 1.1658999719538286 1.0236954876263846 1.0 11.959638695522612 -6.291915728008174 24.990973759719274 1.0071070519607868 1.1980307906163299 0.491577033800741 0.0967108262945053 653.1868187152878 535619.2858242979 0.03293522728949172 0.0373493775106476 5.106040697293304e-07 6.291915728008174 0.19092373865554313 SMDFEEAER ddPTM_A459_Selumetinib_30min_R1 1 SMDFEEAER 9 0 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 0 164.96 0.013619 8358100.0 2216.7 2480.6 2675.0 2967.4 2802.5 2179.1 2980.9 2272.7 1231.2 1695.7 False True 2268.3447970526468 2190.170198800348 2311.7496927232155 2449.1992949967594 2549.014369821562 2157.1802324644946 2756.048313063643 2212.4206132299882 2089.256476709847 1913.3596125167242 1.185529778204629 1.1446725354046345 1.2082149521712082 1.2800517367329722 1.3322191777993755 1.1274306295339132 1.440423585317814 1.1563015121448583 1.09193089633671 1.0 10.901892335782938 -8.286881144744216 2.555667148648745 1.015902189453157 1.2419207722468169 0.43935323842015017 0.08978173932076804 0.2585225940872494 3.11645256447549 0.0831612615862405 0.02362998713411193 5.165577185221453e-09 8.286881144744216 0.22601858279365983 SMESS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SMESSPR 7 0 Q1ED39;H3BPL4 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 SMES(0.012)S(0.988)PR 79.71300000000002 0.046245 71842000.0 131090.0 99655.0 95863.0 110910.0 140890.0 138040.0 273540.0 466870.0 183390.0 314910.0 True False 123804.54259484822 107298.21805867064 89695.27894774252 95803.86666957845 123190.13862741923 157053.7569976432 286260.1520092269 468228.5144055108 220073.12434472915 305817.73006555816 0.40483114752146065 0.35085676044900704 0.2932965296960204 0.3132711326090903 0.4028220947196585 0.5135534717492527 0.936048253146936 1.5310705311465644 0.7196218620076477 1.0 18.222312525138655 -7.245209932767975 2.7618826380541712 1.1142811285435317 0.3545438304078709 0.75091220128782 0.1903916289639889 0.12442035178241695 1.8939350118951603 0.08155481890015769 0.055758367151231086 5.685780205775216e-08 7.245209932767975 -0.7597372981356607 down SMEVLSVTDGGS(ph)PVPAR ddPTM_A459_Selumetinib_30min_R1 3 SMEVLSVTDGGSPVPAR 17 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 SMEVLS(0.016)VT(0.04)DGGS(0.944)PVPAR;S(0.019)MEVLS(0.012)VT(0.009)DGGS(0.96)PVPAR;SMEVLSVTDGGS(1)PVPAR 165.58 1.6079e-06 28044000.0 5357.620000000001 6510.110000000001 4981.889999999999 5685.610000000001 5621.719999999999 5317.39 6043.3 5491.68 2666.5200000000004 4685.66 True False 5482.442121886226 5747.903294731969 4305.376701562936 4692.724945617892 5113.2364185952765 5263.90188440383 5587.449015511256 5346.022806909344 4524.889685084751 5287.110103193441 1.0369449500540575 1.087154075202672 0.8143156880660509 0.8875784415352846 0.9671136630021864 0.9956104150780606 1.0568058743729223 1.0111427041552092 0.8558342074911008 1.0 12.368263655579389 -6.53489806626631 12.785658101315612 0.9882779647742215 0.9521374465327174 0.020700485943720648 0.08457889900747557 3.275563510158547 3458.0634284767643 0.029927686832330973 0.030192010298089666 2.918111846857946e-07 6.53489806626631 -0.036140518241504105 SMEVLSVTDGGS(ph)PVPAR ddPTM_A459_Selumetinib_30min_R2 2 SMEVLSVTDGGSPVPAR 17 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 S(0.026)MEVLS(0.292)VT(0.22)DGGS(0.462)PVPAR;SMEVLS(0.004)VT(0.045)DGGS(0.951)PVPAR 114.56 0.0064491 9570300.0 42688.0 27677.0 32618.0 43051.0 41032.0 29062.0 30937.0 38153.0 32286.0 33015.0 True False 40315.571853603506 29799.73690441844 30519.39339179318 37187.37953288268 35877.193329265814 33065.02670143077 32375.63180050253 38264.01891343083 38744.10214621264 32061.771166728333 1.2574343333670985 0.9294476200161615 0.9518935567559744 1.1598666629956296 1.1190022267546118 1.031291332268741 1.009789248140474 1.1934468222123298 1.2084205187771662 1.0 14.968566505069209 -7.764429240116505 24.995631509548616 1.1507002519721121 1.060295243963047 0.0726218070579141 0.10599924040241449 167.74357476992108 1402307.595271857 0.0546237541280924 0.028003748490363363 1.7201675864353398e-08 7.764429240116505 -0.09040500800906504 SMFGS(ph)LDPPNMPQALPK ddPTM_A459_Selumetinib_30min_R1 2 SMFGSLDPPNMPQALPK 17 0 Q99570 Q99570 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 1 S(0.001)MFGS(0.999)LDPPNMPQALPK;SMFGS(1)LDPPNMPQALPK 139.34 0.00050666 26374000.0 3398.1 4395.799999999999 4691.3 5722.799999999999 4761.5 4011.8 4605.3 3658.4 2034.62 3742.8 True False 3477.269118448413 3881.1376924480232 4054.247227466325 4723.420410260653 4330.823165711104 3971.444934422957 4257.918513251698 3561.367347842032 3452.6015372347197 4223.224837959308 0.8233682202268572 0.9189985949986541 0.9599884881869954 1.1184392476113212 1.0254777644762545 0.9403820745527692 1.0082149723549063 0.8432814932872268 0.8175272853583236 1.0 12.044129340698815 -9.812614119613206 7.899305464715025 1.0000000037863983 0.9465240311359517 0.03318897084250594 0.09112491786869156 0.0 0.0 0.09602848289478226 0.02329032812017683 1.5395219325410315e-10 9.812614119613206 -0.05347597265044657 SMFGS(ph)LDPPNMPQALPK ddPTM_A459_Selumetinib_30min_R2 1 SMFGSLDPPNMPQALPK 17 0 Q99570 Q99570 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 1 SMFGS(1)LDPPNMPQALPK 157.37 4.1534e-05 2870500.0 46012.0 36335.0 45991.0 49853.0 50392.0 39179.0 43140.0 48691.0 35067.0 38831.0 True False 43454.837240629786 39121.777664560635 43031.98913121469 43062.93539877821 44061.30644980416 44575.55161844869 45146.0954802883 48832.68274877103 42081.37985384498 37709.848134945554 1.1523471822301075 1.0374419309396967 1.1411339811612005 1.141954622693693 1.168429697519061 1.1820665906405685 1.1971964278066558 1.2949583507741045 1.1159254660282851 1.0 15.202653720021015 -5.8098885996390885 1.694701764917861 1.1774409706677154 1.0958106304595951 0.056586103334667404 0.07562248971315864 0.6801797109419475 3.9822102452201227 0.023250768721274167 0.04698873059312884 1.5492139549788314e-06 5.8098885996390885 -0.08163034020812021 SMGS(ph)QEDDSGNKPSSYS ddPTM_A459_Selumetinib_30min_R2 2 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 SMGS(1)QEDDSGNKPSSYS;SMGS(0.92)QEDDS(0.008)GNKPS(0.021)S(0.03)YS(0.021) 152.25 0.00084806 15708200.0 64866.0 53458.0 60531.0 58130.0 64065.0 43372.0 46065.0 48896.0 37374.0 54027.0 True False 61261.007399171765 57558.05670543776 56636.501361169656 50212.59372015676 56016.58195163324 49346.099308184406 48207.11377606582 49038.27926483141 44849.844316810726 52467.10013099594 1.1676080295312654 1.097031407524546 1.0794669653890507 0.9570300930447786 1.067651572352488 0.9405150882168206 0.9188065217194374 0.9346481727100658 0.8548184329767222 1.0 15.679125433638342 -5.301361251633372 0.5193385036202927 0.9174033561228602 1.2485802495028322 0.7152015305403743 0.049401996331480104 1.3920026443717828 0.42239989302113895 0.03202021090114553 0.26329857056872824 4.9961877287949125e-06 5.301361251633372 0.331176893379972 SMGSQEDDSGNKPSS(ph)YS ddPTM_A459_Selumetinib_30min_R1 2 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 SMGSQEDDSGNKPS(0.111)S(0.575)YS(0.313);SMGSQEDDSGNKPS(0.101)S(0.516)YS(0.383) 133.94 0.0028047 37218000.0 5502.2 6693.3 6368.4 7555.0 6101.1 5518.1 5570.1 5532.9 3032.7 4727.0 True False 5630.390554582519 5909.645324369247 5503.606259117204 6235.661074914244 5549.2565822366905 5462.592924033931 5149.942872486762 5386.149518607914 5146.270400355714 5333.756494879141 1.0556144735868935 1.1079705888416556 1.0318443041787027 1.1690936923912831 1.0404030606879875 1.024154913948262 0.9655376801380311 1.009822912571857 0.9648491462436596 1.0 12.380936246849519 -6.737588039082193 2.456999575489594 0.9876762299996072 1.0887254038061944 0.6036147922711891 0.03748864780688977 0.18834000588748853 2.330884892285311 0.013427810524802007 0.012605088453875958 1.8298351291475386e-07 6.737588039082193 0.10104917380658718 SMGSQEDDSGNKPSSYS(ph) ddPTM_A459_Selumetinib_30min_R2 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 SMGSQEDDSGNKPS(0.252)S(0.189)Y(0.001)S(0.558) 109.37 0.010647 15861000.0 42431.0 45477.0 45621.0 48644.0 48049.0 36297.0 41511.0 43264.0 36095.0 48565.0 True False 40072.854884751 48964.939668397485 42685.794528389124 42018.6032844195 42012.65505648991 41296.58227863989 43441.34375248601 43389.891077259206 43315.00857856486 47162.80226297626 0.8496707778581043 1.038210990843433 0.9050733306807411 0.8909267742431186 0.8908006530704109 0.8756176541074305 0.9210933546794001 0.9200023958568113 0.9184146509582618 1.0 15.525361820742258 -9.326004114909155 1.2398617626900343 1.0001516293105728 0.9129240228208837 0.2389531723452768 0.047144510353499695 10.381568431498767 14.548379052813312 0.04839225360188698 0.013549734867704635 4.72058568521226e-10 9.326004114909155 -0.08722760648968908 SMGTGDTPGLEVPS(ph)SPLR ddPTM_A459_Selumetinib_30min_R2 1 SMGTGDTPGLEVPSSPLR 18 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDTPGLEVPS(0.5)S(0.5)PLR 239.7 5.3837e-25 45540000.0 40719.0 36464.0 37727.0 43285.0 47144.0 36932.0 36238.0 40639.0 33206.0 40816.0 True False 38456.00099107199 39260.67154976024 35299.6858940518 37389.50832921018 41221.34924729256 42019.04776468384 37923.13880423477 40757.25276185139 39848.127853160426 39637.536027296206 0.9701915115154848 0.9904922324819475 0.8905620639421894 0.9432853824077779 1.0399574085257384 1.0600822345704743 0.9567481383837576 1.0282488985638285 1.0053129393744151 1.0 15.274579663171606 -6.250801703966236 24.5680987453255 1.0158064064265053 0.9474748416746375 0.46508779334536854 0.03488470975336671 533.3201834370605 1231721.215407344 0.01073765170875416 0.013723269393878218 5.61304205378534e-07 6.250801703966236 -0.06833156475186786 SMGTGDTPGLEVPS(ph)SPLRK ddPTM_A459_Selumetinib_30min_R1 4 SMGTGDTPGLEVPSSPLRK 19 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.594)S(0.406)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK 178.1 3.6243e-13 441603700.0 9422.47 10279.2 11182.9 13130.2 10529.1 9030.050000000001 9355.5 9089.26 5383.94 8312.8 True False 9641.99521806498 9075.706485329569 9664.323603272685 10837.25705437975 9576.744764063593 8939.215895629397 8649.807102843739 8848.18329872258 9136.152952580585 9379.828853528945 1.0279500157870578 0.9675769810997183 1.0303304840830552 1.155378975843731 1.0209935504804615 0.9530254800188835 0.9221711011911958 0.9433203352525622 0.9740212849558889 1.0 13.195345883904055 -6.69687772737615 4.678637347783284 0.9524858868085506 1.0439126923621311 0.4288601150510636 0.04748803477498455 0.2086336689256084 8.931196271555432 0.017464612318578873 0.01712804935580048 2.009658538503864e-07 6.69687772737615 0.09142680555358051 SMGTGDTPGLEVPS(ph)SPLRK ddPTM_A459_Selumetinib_30min_R2 10 SMGTGDTPGLEVPSSPLRK 19 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDT(0.002)PGLEVPS(0.579)S(0.419)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.569)S(0.431)PLRK;SMGTGDTPGLEVPS(0.565)S(0.435)PLRK;SMGTGDTPGLEVPS(0.5)S(0.5)PLRK;SMGTGDTPGLEVPS(0.571)S(0.429)PLRK 139.7 6.614e-05 777804600.0 574287.0 555398.0 631290.0 667001.0 661129.0 460641.0 497572.0 504098.0 421174.0 557174.0 True False 542370.4275930102 597995.2407139573 590673.4886965834 576154.313159096 578072.0644517491 524090.1164673381 520710.0839202135 505564.84172208403 505420.56858480396 541086.9389080924 1.0023720563048664 1.1051740445273088 1.0916424814994723 1.064809130898205 1.0683533881233434 0.9685876312685467 0.9623408854979956 0.934350481167238 0.934083845388575 1.0 19.045500891510372 -6.7916116717781225 4.166432270964663 0.9539087717988125 1.0707658338183235 0.7521113555193333 0.030555183328231737 0.09849232493324471 3.7655095778768874 0.010782659318494724 0.009850388007172108 1.6158026952441826e-07 6.7916116717781225 0.11685706201951096 SMGTGDTPGLEVPSS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 9 SMGTGDTPGLEVPSSPLR 18 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDTPGLEVPS(0.009)S(0.991)PLR;SMGTGDTPGLEVPS(0.097)S(0.903)PLR;SMGTGDTPGLEVPS(0.033)S(0.967)PLR;SMGTGDTPGLEVPS(0.041)S(0.959)PLR;SMGTGDTPGLEVPS(0.031)S(0.969)PLR;SMGTGDTPGLEVPS(0.001)S(0.999)PLR;SMGTGDTPGLEVPS(0.002)S(0.998)PLR;SMGTGDTPGLEVPS(0.001)S(0.999)PLR;SMGTGDTPGLEVPS(0.022)S(0.978)PLR 270.95 4.7357999999999977e-54 344894500.0 23163.72 27558.49 27594.5 29707.800000000003 27819.800000000003 23939.000000000004 25407.829999999998 23474.93 13611.64 20860.08 True False 23703.389607246965 24331.929179205596 23847.31846573859 24519.890414472182 25303.504001984606 23698.195394872906 23491.296927138723 22852.298599080863 23097.958925148498 23537.67446238596 1.007040421309498 1.033743975773345 1.0131552504835366 1.0417295240299054 1.0750214105654534 1.0068197447773979 0.9980296466704326 0.9708817511092546 0.9813186498972044 1.0 14.522684167754274 -7.134339998844965 3.039141971619802 0.9844483865237954 1.0336404258583851 0.559042847045285 0.01918431821247468 0.2001399520048154 3.5217925319419265 0.008346986468440563 0.006232183228371828 7.339390597095478e-08 7.134339998844965 0.04919203933458971 SMGTGDTPGLEVPSS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 10 SMGTGDTPGLEVPSSPLR 18 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDTPGLEVPS(0.059)S(0.941)PLR;SMGTGDTPGLEVPS(0.234)S(0.766)PLR;SMGTGDTPGLEVPS(0.247)S(0.753)PLR;SMGTGDTPGLEVPS(0.038)S(0.962)PLR;SMGTGDTPGLEVPS(0.053)S(0.947)PLR;SMGTGDTPGLEVPS(0.002)S(0.998)PLR;SMGTGDTPGLEVPS(0.239)S(0.761)PLR;SMGTGDTPGLEVPS(0.004)S(0.996)PLR;SMGTGDTPGLEVPS(0.205)S(0.795)PLR;SMGTGDTPGLEVPS(0.023)S(0.977)PLR 303.45 6.877399999999997e-96 166339700.0 516657.0 512853.0 582583.0 631182.0 661206.0 471607.0 506484.0 537304.0 479075.0 560844.0 True False 487943.2722818409 552187.1760176951 545100.2440484111 545213.922750317 578139.391023361 536566.5834279007 530036.5095790067 538867.4656845344 574903.3864739151 544650.9764722869 0.8958824887127851 1.0138367502693566 1.0008248724330473 1.0010335908725922 1.0614860084672557 0.9851567455239887 0.9731672804702595 0.9893812532473322 1.0555445804900114 1.0 19.054972491820394 -4.759591270455438 24.996061542806657 1.0078857243385213 0.8958823477231316 0.6082231043751936 0.027208743680775832 33.801484639472115 457044.9384529947 0.0068945045825455145 0.0433782371044521 1.7394371030177617e-05 4.759591270455438 -0.11200337661538973 SMGTGDTPGLEVPSS(ph)PLRK ddPTM_A459_Selumetinib_30min_R1 3 SMGTGDTPGLEVPSSPLRK 19 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDT(0.025)PGLEVPS(0.422)S(0.553)PLRK;SMGTGDT(0.005)PGLEVPS(0.245)S(0.75)PLRK;SMGTGDTPGLEVPS(0.079)S(0.921)PLRK 340.8 1.827999999999999e-173 123995000.0 5873.6 5813.4 6886.6 8350.9 6645.9 5776.2 6364.6 6244.89 3059.57 4640.860000000001 True False 6010.443451963921 5132.76442542366 5951.437545386056 6892.57208080759 6044.779518428944 5718.096672369977 5884.5130978311445 6079.255230938451 5191.866827848562 5236.559586804485 1.1477847912032801 0.9801787491080258 1.136516723763247 1.316240551941023 1.1543417807487724 1.0919567661903264 1.1237364915429258 1.1609254378117764 0.9914652438848317 1.0 12.354403558792239 -8.266135371247293 24.49641974314481 0.9957325860706745 1.1379338327220936 0.3538187685086909 0.07741363933054494 386.68391128766723 2017068.8789361601 0.07202693061765868 0.02100817937188969 5.4183197298326024e-09 8.266135371247293 0.1422012466514191 SMGTGDTPGLEVPSS(ph)PLRK ddPTM_A459_Selumetinib_30min_R2 2 SMGTGDTPGLEVPSSPLRK 19 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SMGTGDTPGLEVPS(0.179)S(0.821)PLRK;SMGTGDTPGLEVPS(0.267)S(0.733)PLRK 91.622 0.013517 10376400.0 60610.0 66959.0 80407.0 84446.0 79274.0 60163.0 59375.0 64948.0 62202.0 74296.0 True False 57241.53884105392 72094.53999288044 75233.70116052227 72944.30912252465 69314.89140144813 68449.90714466244 62136.055149330496 65136.987927279806 74644.13806909251 72150.88143580957 0.7933588294687705 0.99921911635994 1.042727402124053 1.0109967843902359 0.9606936190116466 0.9487050716845398 0.8611960645915469 0.902788526363745 1.0345561493313302 1.0 16.138729399148858 -6.758925495656686 3.988216483698267 0.9373116920865776 0.9713402115463012 0.0 0.0772128263054272 0.9074426119026522 32.24481530569938 0.028149373427692782 0.02634848578378319 1.7421057105049164e-07 6.758925495656686 0.03402851945972363 SMGYDDLDY(ph)GMMSDYGTAR ddPTM_A459_Selumetinib_30min_R1 1 SMGYDDLDYGMMSDYGTAR 19 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 S(0.055)MGY(0.03)DDLDY(0.757)GMMS(0.157)DY(0.001)GTAR 128.68 0.013595 16388000.0 1903.9 2122.2 1584.6 1399.3 2210.6 1466.2 2243.4 1640.7 1291.5 2011.1 True False 1948.2571656554926 1873.7318374159863 1369.42002358475 1154.9385231141628 2010.6516203131298 1451.4513592030858 2074.1785318282978 1597.1833062553096 2191.5811725720973 2269.244274772886 0.8585488954689469 0.8257074208564505 0.6034696391254778 0.5089529302568156 0.8860445932002463 0.639618826117057 0.9140393367461019 0.703839301925819 0.9657757857696649 1.0 11.147996202193633 -8.260426339174467 0.875532612066226 1.0073843865179624 0.7201589957223438 0.34121269202761817 0.12817940139038309 0.668601432607414 1.0891057122763825 0.12311759105396507 0.045376983126629675 5.490016640580125e-09 8.260426339174467 -0.2872253907956186 SMGYDDLDYGMMS(ph)DYGTAR ddPTM_A459_Selumetinib_30min_R1 1 SMGYDDLDYGMMSDYGTAR 19 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 S(0.191)MGY(0.004)DDLDY(0.042)GMMS(0.655)DY(0.079)GT(0.028)AR 124.39 0.0015388 7416200.0 1025.0 1363.0 1023.2 1242.2 1432.9 1198.9 1294.0 1181.0 949.95 1172.0 True False 1048.880505697191 1203.4193263584916 884.255060035288 1025.2730889819286 1303.2944479990424 1186.8401545141046 1196.3925381946233 1149.6760435713538 1611.9957683971086 1322.4376162467433 0.793141765487627 0.9100008284503872 0.668655405118408 0.7752903247654072 0.9855243317245982 0.8974640012755515 0.9046873164347419 0.8693612684992202 1.2189578915428694 1.0 10.368983951913117 -7.38946217438341 0.6671568825448574 1.0643453357968016 0.7974434420383238 0.45308363363848636 0.10473119041661501 0.7250477941064333 0.6359261734354374 0.09495519662571046 0.05932418691992959 4.0788508566954586e-08 7.38946217438341 -0.2669018937584777 SMIIDRR ddPTM_A459_Selumetinib_30min_R2 1 SMIIDRR 7 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 114.72 0.018352 2451500.0 18504.0 19004.0 21062.0 23704.0 22229.0 15521.0 10984.0 13898.0 8633.5 17870.0 False True 17475.621757380988 20461.545692508887 19706.893850571698 20475.474308319215 19436.39429021862 17658.87686439016 11494.777764383087 13938.440879062236 10360.441240145166 17354.04666816402 1.0070055757911494 1.1790648074057315 1.1355791664847814 1.1798674222699568 1.1199920492247302 1.0175653668596703 0.6623687249539465 0.8031810185593364 0.5970043436123393 1.0 14.082984493497985 -7.0922273961765 3.7431408031746014 0.7503912837452218 1.1280102624217243 0.7075367195066152 0.10867087320174594 0.11934987290178953 3.0791350789099665 0.04066683888288746 0.03140783513416509 8.086723682271552e-08 7.0922273961765 0.3776189786765025 SMLLMEAEDR ddPTM_A459_Selumetinib_30min_R1 1 SMLLMEAEDR 10 0 A0A1B0GU80;Q96N23-2;Q96N23 A0A1B0GU80 CFAP54 Cilia- and flagella-associated protein 54 0 90.906 0.044133 0.0 3215.5 2659.6 3697.6 2570.4 4492.0 3215.3 3344.4 3677.1 1409.6 2895.9 False True 3290.4148937261616 2348.212795585504 3195.486229462938 2121.527892383794 4085.699393127014 3182.9570012588197 3092.1292154081143 3579.5713630958726 2391.9882468893757 3267.6169734547307 1.006976925526044 0.71863159441935 0.9779255816768722 0.6492584380661914 1.2503605613259363 0.9740912191105424 0.9462948811099241 1.0954684689715404 0.7320283455255818 1.0 11.674023166896248 -6.247963786691083 24.999730878623854 1.0005292642115498 0.8396382253679404 0.20337463565288683 0.15658072766459824 1285.7344550735695 2385275.8831612305 0.04390473635199333 0.05635474186679508 5.64984083608317e-07 6.247963786691083 -0.16089103884360934 SMMS(ph)PMADR ddPTM_A459_Selumetinib_30min_R2 1 SMMSPMADR 9 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 SMMS(1)PMADR 143.24 0.0020506 12120000.0 15270.0 14768.0 16207.0 19252.0 21184.0 12045.0 15274.0 16415.0 15846.0 17945.0 True False 14421.354530653236 15900.658113395659 15164.25926484739 16629.844388447596 18522.676532637142 13704.089416376499 15984.271264856832 16462.764932350463 19015.64277423298 17426.88122329062 0.8275350216640848 0.9124213282721408 0.8701648373307732 0.9542639428919845 1.062879599356081 0.78637647441249 0.9172192694751501 0.9446764869406674 1.0911672909561705 1.0 14.089026782272573 -1.5228787686425576 0.14145700722844226 1.035281389397897 0.40581229046558076 0.2615702395941947 0.07879094861342863 119.95025825804677 1.1318279683442298 0.3445850211591674 15.29224149655722 0.02999999838619506 1.5228787686425576 -0.6294690989323162 SMMS(ph)PMAER ddPTM_A459_Selumetinib_30min_R1 1 SMMSPMAER 9 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 S(0.006)MMS(0.994)PMAER 97.813 0.020257 8000200.0 1834.0 2181.0 2192.0 2472.9 2358.1 2257.0 2310.3 2234.6 904.42 1596.8 True False 1876.728631657216 1925.6475060806076 1894.338439794127 2041.0544370821224 2144.810271356369 2234.296629192036 2136.0322109667986 2175.331148996229 1534.7346837767373 1801.764834149146 1.041605761244347 1.0687562935980839 1.051379405286649 1.1328084544651338 1.1903941239752416 1.240060071572629 1.185522200501546 1.2073335586125442 0.8517952258189624 1.0 10.815195007940767 -8.260222966693387 24.998780213966477 0.9258976044300024 1.1407500067501322 0.5807468028032287 0.0726705855233829 80.73905586976606 1659385.2645231269 0.061788637493427716 0.020417355925604022 5.492588121028693e-09 8.260222966693387 0.2148524023201298 SMMS(ph)PMAER ddPTM_A459_Selumetinib_30min_R2 3 SMMSPMAER 9 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;H7C1M2 P18583-10 SON Protein SON 1 S(0.02)MMS(0.98)PMAER;S(0.001)MMS(0.999)PMAER;S(0.019)MMS(0.981)PMAER 103.31 0.015352 29316000.0 41017.7 38452.3 43788.5 51061.5 51672.1 34671.7 36739.2 39048.9 39185.200000000004 44667.1 True False 38738.10044086281 41401.46776636811 40971.195583314 44106.835613999414 45180.588843564925 39447.41195664432 38447.6455973437 39162.52583410661 47023.33492596708 43377.44476393673 0.8930470813040838 0.9544469018790287 0.9445276411803942 1.0168149796289774 1.041568702108689 0.9093991628903008 0.8863510934444995 0.9028315532930069 1.0840503672328223 1.0 15.404657450195117 -4.596501121982044 1.7965179521799661 0.9683011554769843 0.8377719984890093 0.13184625244193404 0.06093266742075861 3.792653250730031 8.417930786397976 0.017481462427108012 0.9847161442590502 2.5322050934240145e-05 4.596501121982044 -0.13052915698797496 SMS(ph)AAFCSLLAPER ddPTM_A459_Selumetinib_30min_R1 2 SMSAAFCSLLAPER 14 0 E9PNR2;Q13671-2;Q13671 E9PNR2 RIN1 Ras and Rab interactor 1 1 S(0.372)MS(0.628)AAFCSLLAPER;S(0.012)MS(0.988)AAFCSLLAPER 216.27 1.3458e-08 84557800.0 3787.74 4232.65 5337.59 4793.61 4355.5 4475.73 4372.18 4510.7699999999995 2746.22 3086.72 True False 3875.986972340951 3737.089370294397 4612.774595283182 3956.496000704126 3961.5457940259816 4430.708219837692 4042.3829425376894 4391.12972655407 4660.13476402706 3482.9305791989277 1.1128522042585258 1.0729726835824347 1.324394641349446 1.1359675166463175 1.1374173857169256 1.2721207382941158 1.1606269061691823 1.2607571775272155 1.33799243426175 1.0 11.766086002478039 -6.742489671113624 24.98186155987456 1.2197422602711085 1.1602304504030494 0.045723794311697374 0.10397487811483701 713.4665809882814 940578.319777751 0.03357149317632986 0.03351727066213692 1.8092989405517573e-07 6.742489671113624 -0.05951180986805915 SMS(ph)AAFCSLLAPER ddPTM_A459_Selumetinib_30min_R2 1 SMSAAFCSLLAPER 14 0 E9PNR2;Q13671-2;Q13671 E9PNR2 RIN1 Ras and Rab interactor 1 1 S(0.027)MS(0.973)AAFCSLLAPER 162.41 0.00027587 19241000.0 12669.0 10005.0 12354.0 11310.0 12026.0 11827.0 8979.0 11210.0 8021.0 9154.4 True False 11964.907698025274 10772.351328854516 11559.157090018176 9769.558489161764 10515.186366195923 13456.061895183462 9396.541291550966 11242.6192440846 9625.42412546527 8890.088686012352 1.3458704542341446 1.2117259691462599 1.3002296712973551 1.0989269999671845 1.182798815352708 1.5136026613947287 1.0569682287124387 1.2646239695869081 1.0827140724265094 1.0 13.117982095869216 -8.419062403995904 1.2298161968680514 0.9976364647188193 1.2516515524912322 0.3202547682159912 0.12183711599435226 0.5608340943826262 1.8259257194297398 0.1130497580064327 0.03551244477483152 3.810110717847326e-09 8.419062403995904 0.2540150877724129 SMS(ph)AEDLLER ddPTM_A459_Selumetinib_30min_R1 1 SMSAEDLLER 10 0 A0A2R8Y5P9;Q8TF72 A0A2R8Y5P9 SHROOM3 Protein Shroom3 1 S(0.028)MS(0.972)AEDLLER 116.71 0.0062495 2415500.0 2106.3 1648.0 1236.5 1374.6 2978.5 998.2 2115.9 1705.2 559.63 902.21 True False 2155.372691853652 1455.0513938655856 1068.5900916083194 1134.5519144377392 2709.0952008968857 988.1590142930836 1956.2959594791362 1659.9725567297826 949.6512362419842 1018.0174417696019 2.117225701071492 1.4292990809040513 1.0496775868110944 1.114471980426551 2.6611481196115 0.9706700236642155 1.9216723399930566 1.6305934344742476 0.9328437777954198 1.0 9.991546564090378 -8.261585942961535 24.935202759487183 0.966421806802065 1.5943738082525405 0.21220402671932093 0.4965207491675579 20.169915774583036 3429733.2859263197 0.38602720458871076 0.1237756867772152 5.475377374595773e-09 8.261585942961535 0.6279520014504755 SMS(ph)APSDLEMIGNEDLEFTR ddPTM_A459_Selumetinib_30min_R1 2 SMSAPSDLEMIGNEDLEFTR 20 0 F8VWT9;J3KPF0;Q9Y4D8-2;Q9Y4D8-4;Q9Y4D8 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 1 S(0.008)MS(0.888)APS(0.104)DLEMIGNEDLEFTR;S(0.074)MS(0.915)APS(0.01)DLEMIGNEDLEFTR 219.72 1.6779e-19 10433600.0 4322.4 5194.0 4956.2 5536.7 5421.1 3835.0 4550.8 4448.3 2539.4700000000003 3428.3999999999996 True False 4423.103510073692 4585.884065374911 4283.175262457868 4569.819281730999 4930.762462172942 3796.423381901398 4207.529492129903 4330.316633885227 4309.295114449605 3868.4685354439694 1.143373267624644 1.1854520783503302 1.1072017836552739 1.1812993281090596 1.2746032226954787 0.9813763113535825 1.0876473347474236 1.1193878389366951 1.1139537713611114 1.0 11.917546824261034 -6.765200474393907 24.999999995939902 1.069633199205694 1.1749856747235485 0.5089955405766282 0.05750609912370664 94.88965040390643 630726.6190287271 0.020396846945036035 0.018670624821155876 1.717115567582564e-07 6.765200474393907 0.10535247551785454 SMS(ph)APVIFDR ddPTM_A459_Selumetinib_30min_R2 1 SMSAPVIFDR 10 0 O60749;D6RC15 O60749 SNX2 Sorting nexin-2 1 S(0.01)MS(0.99)APVIFDR 123.01 0.004287399999999999 1820100.0 13408.0 11597.0 14690.0 13370.0 16470.0 9008.8 12290.0 14855.0 11646.0 14200.0 True False 12662.837036476667 12486.452609767706 13744.86139326267 11548.98293546355 14400.89135633184 10249.680426255924 12861.509352172992 14898.225590622362 13975.525416427943 13790.009103969172 0.918261687936952 0.9054709475263316 0.9967260564974169 0.8374891451042923 1.0442989013101405 0.7432685757477682 0.9326686628851514 1.0803637240771808 1.0134529506877101 1.0 13.75133578884854 -7.65221643863008 6.308527754182587 1.034176383249581 0.9086405251681173 0.329027747217132 0.07908107647268847 0.23395859834746122 12.088872280543747 0.036309507235623706 0.020643812145878872 2.2273248443859257e-08 7.65221643863008 -0.1255358580814636 SMS(ph)DVSAEDVQNLR ddPTM_A459_Selumetinib_30min_R1 3 SMSDVSAEDVQNLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.019)MS(0.981)DVSAEDVQNLR;S(0.018)MS(0.982)DVSAEDVQNLR;S(0.227)MS(0.76)DVS(0.013)AEDVQNLR 158.65 0.00030415 21129200.0 4667.1 4967.6 5991.9 5778.9 5396.0 4569.8 4564.6 4652.9 2697.52 3901.4999999999995 True False 4775.834349404253 4385.9910826254145 5178.23289115074 4769.723598388077 4907.932752741179 4523.831961046421 4220.288547019457 4529.489977250766 4577.494420934332 4402.295528828211 1.0848509188285842 0.9962963762664211 1.176257445062773 1.0834628359576912 1.1148576283899678 1.0276075132671887 0.9586563463045835 1.0288927555157596 1.0397971674002437 1.0 12.104040282155015 -6.890922189276661 5.464730671163678 1.0071899165963625 1.0898375363191037 0.43868861497866063 0.045725690149992296 0.21041962671739872 9.338640335508472 0.016596267377135376 0.014621477463207943 1.2855169600015615e-07 6.890922189276661 0.08264761972274126 SMS(ph)DVSAEDVQNLR ddPTM_A459_Selumetinib_30min_R2 3 SMSDVSAEDVQNLR 14 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;E9PJ10;Q8WWI1-3;E9PMP7;E9PK58;E9PLU6 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.312)MS(0.688)DVSAEDVQNLR;S(0.019)MS(0.981)DVSAEDVQNLR;S(0.005)MS(0.994)DVS(0.001)AEDVQNLR 128.85 0.0041776 13137400.0 47869.2 56332.0 56539.5 60521.9 62987.4 54447.5 55086.1 52013.4 49871.0 57922.1 True False 45208.821499590435 60652.483264071234 52901.8101255531 52278.712813899125 55074.359697499465 61947.14889980567 57647.71280103634 52164.75038271811 59846.59351216538 56249.738473310776 0.8037161189832197 1.078271382414506 0.9404809970921697 0.9294036600490896 0.9791042801671158 1.1012877673946553 1.0248529924879362 0.92737765185289 1.063944386880327 1.0 15.779558768250062 -6.528756842708453 24.928994611108386 1.0213895073463735 0.9489297913520987 0.22063005827331095 0.07468018157979744 266.1158777856423 1128585.737311615 0.02397229209149918 0.024036740092349664 2.959669092922143e-07 6.528756842708453 -0.07245971599427481 SMS(ph)ENAVR ddPTM_A459_Selumetinib_30min_R1 3 SMSENAVR 8 0 A0A0A0MS29;Q9GZY8-2;C9JHF5;H7C433;Q9GZY8-4;Q9GZY8-3;Q9GZY8;Q9GZY8-5 A0A0A0MS29;Q9GZY8-5 MFF Mitochondrial fission factor 1 S(0.291)MS(0.709)ENAVR;S(0.016)MS(0.984)ENAVR;S(0.002)MS(0.998)ENAVR 110.54 0.011981 193970000.0 8898.5 11099.099999999999 11156.2 10063.9 10697.2 11428.6 9748.199999999999 12270.7 5087.299999999999 7809.599999999999 True False 9105.817736533118 9799.612212168397 9641.249316620086 8306.428787800063 9729.640148744058 11313.638660338545 9012.885425679153 11945.241175149036 8632.776538308965 8812.038231945873 1.0333384282789673 1.1120710049398466 1.0940998056122944 0.9426228721622147 1.1041304965599952 1.2838844274782804 1.0227923652220616 1.3555593905442338 0.9796571815829124 1.0 13.10526003899719 -6.519819425491786 24.99374550876471 1.1495581504230816 1.0499575266452537 0.08250080514759006 0.12057659431630582 251.28518022136916 2052950.1992699024 0.03681041347784748 0.03751245984276245 3.0212076416842247e-07 6.519819425491786 -0.09960062377782797 SMS(ph)ENAVR ddPTM_A459_Selumetinib_30min_R2 2 SMSENAVR 8 0 A0A0A0MS29;Q9GZY8-2;C9JHF5;H7C433;Q9GZY8-4;Q9GZY8-3;Q9GZY8;Q9GZY8-5 A0A0A0MS29;Q9GZY8-5 MFF Mitochondrial fission factor 1 S(0.05)MS(0.95)ENAVR;S(0.002)MS(0.998)ENAVR 108.31 0.012929 90379000.0 303430.0 127239.0 244770.0 369660.0 318018.0 273550.0 392990.0 272120.0 386610.0 244400.0 True False 286566.5753265302 136997.82216213088 229021.76468542605 319311.6703009313 278065.7357230077 311229.02946033963 411264.81369491183 272911.824148109 463942.8027859523 237343.53697254008 1.2073915261475399 0.5772131986807844 0.9649378601445683 1.3453565004294796 1.1715749216090052 1.3113018935769374 1.7327828637798295 1.1498599356412391 1.9547311407920454 1.0 17.85661723916259 -6.012036390376115 1.14371491615246 1.4499787966124018 0.8595748509724168 0.32078539308354614 0.3035105577423471 0.5374883652544841 1.4317475347620972 0.1129055612774293 0.22132663866846586 9.726657188170958e-07 6.012036390376115 -0.590403945639985 SMS(ph)FQGIR ddPTM_A459_Selumetinib_30min_R1 2 SMSFQGIR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 S(0.001)MS(0.999)FQGIR;S(0.001)MS(0.999)FQGIR 128.91 0.0042103 34073000.0 6089.700000000001 6127.2 5964.700000000001 6307.8 7362.2 5204.5 6404.0 6304.799999999999 2211.5299999999997 6171.9 True False 6231.578161506518 5409.824575541997 5154.726501751837 5206.261142070692 6696.290309901977 5152.147455307911 5920.94112411002 6137.576223123343 3752.8048862395426 6964.123484396989 0.8948115546009878 0.7768134191851459 0.7401830988926205 0.7475831170620738 0.961541007264577 0.7398127656482855 0.8502062229907033 0.8813135259411307 0.5388768442500544 1.0 12.7657260690336 -4.751779386536519 23.62163533850098 0.8009259298294682 0.8948119422635988 0.04547400082695241 0.12403205636483548 671.9665010003464 1642921.4718807342 0.029010192081732656 0.35013504790447675 1.771008368940756e-05 4.751779386536519 0.09388601243413064 SMS(ph)FQGIR ddPTM_A459_Selumetinib_30min_R2 2 SMSFQGIR 8 0 P15924-2;P15924-3;P15924 P15924-2 DSP Desmoplakin 1 SMS(1)FQGIR;S(0.001)MS(0.999)FQGIR 136.52 0.0025896 34208800.0 48839.0 41131.0 63635.0 51630.0 48185.0 33971.0 25546.0 30866.0 29248.2 54006.0 True False 46124.72389800742 44285.615442990056 59540.79338054935 44597.90493328221 42131.569520634504 38650.1968919656 26733.939618438693 30955.81494985864 35098.65726298883 52446.706455560525 0.8794589215452473 0.8443926880425642 1.1352627725250934 0.8503471037036652 0.8033215499687038 0.7369423078018241 0.5097353375486231 0.5902337256599386 0.669225193248862 1.0 15.678564556938811 -6.517484520337121 1.8503307837012057 0.6597682993214392 0.9400092074545904 0.35128038160219677 0.14238818818809174 0.33095423820778336 2.285676681203511 0.05289595382785305 0.05775249744031997 3.0374943561599944e-07 6.517484520337121 0.28024090813315117 SMS(ph)IDDTPR ddPTM_A459_Selumetinib_30min_R2 1 SMSIDDTPR 9 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7;A0A0C4DGY6;A0A1B0GVW2 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 S(0.032)MS(0.967)IDDTPR 108.31 0.012082 4213100.0 33255.0 30575.0 38593.0 37162.0 38144.0 27448.0 24402.0 29841.0 26799.0 31187.0 True False 31406.82023031263 32920.00418587975 36109.96839688132 32100.471491974316 33352.009708313424 31228.71285186402 25536.74135164568 29927.832369556498 32159.54882662307 30286.550276442733 1.0369890246213105 1.0869512666645746 1.1922773662660457 1.0598919718150428 1.1012152062182878 1.0311082829447933 0.8431710154691499 0.9881558677494792 1.0618425846814643 1.0 14.88638964000366 -6.970175686775778 5.2419693422522124 0.9675520255677172 1.096663861301502 0.45076971637462027 0.06337613444974541 0.16724497623644732 12.225474677461422 0.023833212335147267 0.02045966471890193 1.0710859271777879e-07 6.970175686775778 0.12911183573378482 SMS(ph)PFR ddPTM_A459_Selumetinib_30min_R2 1 SMSPFR 6 0 B4DZM6;Q99640-4;Q99640-3;Q99640;I3L1H7;I3L4K3;I3L3P0;I3L136;A6NHV6;Q99640-2 B4DZM6 PKMYT1 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 1 SMS(1)PFR 92.47 0.043433 4233900.0 15813.0 8329.8 14093.0 15351.0 8527.4 8264.1 25395.0 12104.0 14273.0 10376.0 True False 14934.176764454462 8968.668875471507 13186.271723298214 13260.167318047932 7456.111776076759 9402.40476096944 26575.917819237846 12139.220636074933 17127.998820940746 10076.417919914378 1.4820918389003621 0.8900651944721757 1.3086269176308898 1.3159604358847996 0.7399565833152855 0.9331098447581395 2.637437036698818 1.2047158754783052 1.6998102854676245 1.0 13.298695243820832 SMS(ph)PTSTPK ddPTM_A459_Selumetinib_30min_R1 3 SMSPTSTPK 9 0 O94913;E9PKN0;E9PQ01 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 SMS(0.894)PT(0.076)S(0.023)T(0.007)PK;S(0.009)MS(0.556)PT(0.146)S(0.28)T(0.009)PK;SMS(0.923)PT(0.022)S(0.054)T(0.001)PK 126.71 0.0047394 63428900.0 14087.5 16930.6 17941.199999999997 18589.3 15716.7 15021.5 15348.199999999999 14514.699999999999 8476.1 13640.199999999999 True False 14415.71134049676 14948.357481177589 15504.883583957293 15343.02771937834 14295.127260008758 14870.397348430732 14190.472917093284 14129.723005609767 14383.32263014971 15391.052536799327 0.9366293374692491 0.9712368563122454 1.0073959235007353 0.996879692450782 0.9287946503872779 0.9661715670761482 0.9219949631881569 0.918047870464104 0.9345249518029921 1.0 13.909804275133547 -6.266190178041013 24.99718127632842 0.9407408199578307 0.979647015205836 0.2349314665478215 0.028625718342275955 515.8212390686429 2714083.0443567177 0.008865914472107914 0.01038000608990843 5.417635995622101e-07 6.266190178041013 0.038906195248005315 SMS(ph)PTSTPK ddPTM_A459_Selumetinib_30min_R2 4 SMSPTSTPK 9 0 O94913;E9PKN0;E9PQ01 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 S(0.037)MS(0.85)PT(0.092)S(0.02)T(0.001)PK;S(0.013)MS(0.941)PT(0.045)STPK;S(0.004)MS(0.32)PT(0.32)S(0.32)T(0.035)PK;S(0.002)MS(0.865)PT(0.11)S(0.022)T(0.001)PK 126.03 0.0049031000000000005 132427000.0 401076.0 387668.0 395739.0 422489.0 419018.0 321095.0 326352.0 321691.0 270660.0 393940.0 True False 378785.8015544389 417400.88905091246 370277.58358804556 364945.2693658239 366377.2127715518 365322.92163980176 341528.0146542197 322627.0675511884 324799.5628722639 382565.92862095905 0.9901190179686246 1.0910560973255603 0.9678791441851357 0.9539408558450236 0.9576838535837131 0.9549280119029068 0.892729825380244 0.8433241002777401 0.8490028478047524 1.0 18.54534886720507 -6.149674571373988 0.7422332320512821 0.887821022945487 1.0422122252475587 0.45690202996657747 0.05173636870181872 0.6435602034322757 0.7396375274881711 0.029376820514777652 0.06032349983769199 7.084764661501781e-07 6.149674571373988 0.1543912023020717 SMS(ph)YSSQK ddPTM_A459_Selumetinib_30min_R2 2 SMSYSSQK 8 0 Q9C0B5-2;Q9C0B5 Q9C0B5-2 ZDHHC5 Palmitoyltransferase ZDHHC5 1 S(0.026)MS(0.888)YS(0.043)S(0.043)QK;S(0.005)MS(0.456)YS(0.456)S(0.083)QK 104.42 0.014616999999999996 10647000.0 75361.0 31473.0 60695.0 67631.0 43495.0 27270.0 76730.0 61664.0 34380.0 46051.0 True False 71172.73731398548 33886.87789835465 56789.94977971941 58419.54113001766 38030.76924976647 31026.194967587126 80298.0970376105 61843.43203097527 41256.96065746116 44721.387975132726 1.5914697762413141 0.757733143640296 1.2698610743319818 1.3062998215194432 0.8503933122762968 0.6937663693452271 1.795518893158239 1.3828603008780327 0.9225330993841704 1.0 15.448677343977575 -10.026291757537608 15.912955847514128 1.000004173412436 1.1696394202198386 0.02210393501256902 0.3468358553520158 0.0 0.0 0.3369626646294695 0.08172545047981666 9.412570508297489e-11 10.026291757537608 0.1696352468074025 SMSSIPPYPASS(ph)LASSSPPGSGR ddPTM_A459_Selumetinib_30min_R1 1 SMSSIPPYPASSLASSSPPGSGR 23 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 SMSSIPPYPAS(0.211)S(0.701)LAS(0.036)S(0.036)S(0.016)PPGSGR 209.73 5.8749e-24 21442000.0 5539.2 7598.9 7175.9 7906.0 7300.6 6852.4 6776.0 6553.5 3440.9 5818.0 True False 5668.252582593052 6709.217255367231 6201.4521943972 6525.365514000268 6640.262019025618 6783.471077481393 6264.880864611101 6379.679891231896 5838.955986607306 6564.796972119072 0.8634315130637433 1.0219992002588225 0.9446525491549838 0.9939934992222501 1.0114954121547168 1.033310109404912 0.9543144885086735 0.9718015527862667 0.8894343589612232 1.0 12.680534678591176 -4.748513359107183 24.996540187301537 0.9803928457691171 0.8634312350008766 0.4280205738551328 0.040463347146554814 630.4994109959517 1219197.6306316848 0.010171508647744722 0.18370327398056324 1.7843770993982e-05 4.748513359107183 -0.11696161076824052 SMSSIPPYPASSLAS(ph)SSPPGSGR ddPTM_A459_Selumetinib_30min_R2 1 SMSSIPPYPASSLASSSPPGSGR 23 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 SMSSIPPYPASSLAS(0.403)S(0.403)S(0.191)PPGS(0.002)GR 206.11 9.2987e-24 10622000.0 49943.0 48235.0 57410.0 52292.0 64576.0 36152.0 42271.0 41159.0 37170.0 50197.0 True False 47167.3679976696 51934.46940002975 53716.3031032818 45169.73939126851 56463.38556323531 41131.60984481886 44236.68525839743 41278.76587576076 44605.0386165745 48747.682182531025 0.967581757447583 1.0653731023675364 1.1019252751781357 0.9266028120503196 1.1582783639192027 0.843765446956134 0.9074623300602765 0.8467841757316045 0.9150186556471589 1.0 15.573046003883213 -6.778290203686562 24.99995004595698 0.8933336327196053 1.0418436416869044 0.4820192189151531 0.07292958703435767 194.72243501667523 288889.07844836684 0.024100294436333793 0.021310384091057077 1.666133498958663e-07 6.778290203686562 0.14851000896729905 SMSSIPPYPASSLASSS(ph)PPGSGR ddPTM_A459_Selumetinib_30min_R1 1 SMSSIPPYPASSLASSSPPGSGR 23 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 SMSSIPPYPAS(0.01)S(0.01)LAS(0.175)S(0.175)S(0.616)PPGS(0.013)GR 160.02 1.1915e-09 17827000.0 5687.0 6434.6 6129.7 7361.5 6662.2 5837.4 6241.8 6422.6 3353.0 4495.8 True False 5819.4960350243155 5681.23404063562 5297.320408031957 6075.952217469387 6059.605186306946 5778.681055935132 5770.976000697989 6252.2517844550175 5689.7961065692925 5072.8797228004305 1.1471780040177502 1.1199228743983218 1.0442432498887686 1.1977323629733567 1.1945099267919965 1.1391322821951455 1.1376134101425495 1.232485713460505 1.1216106861347581 1.0 12.30858923945867 -5.776080790191911 24.999437754486706 1.1572080942937728 1.105395498058077 0.06608569251662733 0.06410073595923055 478.9117263296513 817715.6396113017 0.017177805294491876 0.025605819758329252 1.6746313215941998e-06 5.776080790191911 -0.051812596235695896 SMSSIPPYPASSLASSS(ph)PPGSGR ddPTM_A459_Selumetinib_30min_R2 4 SMSSIPPYPASSLASSSPPGSGR 23 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 SMSSIPPYPAS(0.002)S(0.002)LAS(0.27)S(0.27)S(0.457)PPGSGR;SMSSIPPYPAS(0.003)S(0.003)LAS(0.288)S(0.288)S(0.417)PPGS(0.001)GR;SMSSIPPY(0.002)PAS(0.014)S(0.014)LAS(0.184)S(0.184)S(0.593)PPGS(0.009)GR;SMSSIPPYPAS(0.098)S(0.098)LAS(0.067)S(0.295)S(0.437)PPGS(0.004)GR 191.71 2.5715e-22 17637700.0 226590.4 220913.6 246024.4 256696.5 250058.8 159268.3 178418.6 204289.7 174640.8 208936.8 True False 213997.4126812396 237856.9627708188 230195.457955113 221733.99387383845 218644.1779899643 181206.06263132207 186715.41842974874 204884.14920501978 209573.83987165644 202904.25170099904 1.0546719001067928 1.1722620929665204 1.134502880177841 1.0928011217852007 1.0775731713703056 0.8930619300099657 0.920214420666225 1.0097577920986018 1.0328706181104856 1.0 17.63043957040216 -6.595092740695963 6.020439043317169 0.9689426122712185 1.11535184732007 0.6721773634409169 0.047673397073358534 0.12745231857246422 8.03604263463415 0.01697756443573504 0.016997163754421094 2.540430155671669e-07 6.595092740695963 0.14640923504885162 SMVWPGDGLVPDT(ph)AEPHVAPSPTLPSTEDVIR ddPTM_A459_Selumetinib_30min_R1 2 SMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIR 32 0 F8VXI9;Q14161-6;Q14161-4;Q14161-3;Q14161;R4GNG3;F8WAK2;Q14161-11;Q14161-7;Q14161-9;Q14161-10;Q14161-8;Q14161-5 F8VXI9 GIT2 ARF GTPase-activating protein GIT2 1 SMVWPGDGLVPDT(0.974)AEPHVAPS(0.013)PT(0.006)LPS(0.002)T(0.006)EDVIR;S(0.286)MVWPGDGLVPDT(0.714)AEPHVAPSPTLPSTEDVIR 108.69 1.0089e-11 12911100.0 1605.1399999999999 1620.05 1672.1799999999998 1444.6599999999999 1623.0 1776.65 1948.9 1016.35 871.81 1369.04 True False 1642.536638941256 1430.3737928591875 1445.1071406272547 1192.3772506268178 1476.1999365639235 1758.7785140691326 1801.892903931608 989.3930964299284 1479.3978955169043 1544.7696195788733 1.063289061438841 0.9259463513071472 0.9354839209106223 0.7718803085678738 0.9556117092504429 1.1385377416657128 1.1664476573683722 0.640479385333621 0.9576818942880362 1.0 10.593175981384697 -8.40915686885964 0.005908797175829959 0.7283079579432173 1.1668869573149658 0.0 0.15042453467895353 174584.16618085047 763.7279112118669 28516.42600923404 28156.214310874722 3.898011635455181e-09 8.40915686885964 0.4385789993717485 SMVWPGDGLVPDT(ph)AEPHVAPSPTLPSTEDVIR ddPTM_A459_Selumetinib_30min_R2 1 SMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIR 32 0 F8VXI9;Q14161-6;Q14161-4;Q14161-3;Q14161;R4GNG3;F8WAK2;Q14161-11;Q14161-7;Q14161-9;Q14161-10;Q14161-8;Q14161-5 F8VXI9 GIT2 ARF GTPase-activating protein GIT2 1 S(0.007)MVWPGDGLVPDT(0.992)AEPHVAPS(0.001)PTLPSTEDVIR 79.163 1.4101e-05 1854400.0 701.96 1157.9 599.2 1744.3 2757.8 975.09 1988.7 1832.8 1603.2 1310.0 True False 662.9478733685236 1246.7072067646825 560.6481243596318 1506.723330914665 2411.3405089551884 1109.3997965142846 2081.178490534291 1838.133144563627 1923.8847971507196 1272.17689621124 0.5211129641977429 0.9799794434858778 0.4406998162200065 1.1843662114930276 1.8954443490811475 0.8720483761482122 1.6359191058510776 1.4448722894103023 1.5122777365949476 1.0 10.313083575993945 -5.928071207889761 5.706681570922978 1.4136043487666918 0.6881843415354898 0.5419593885658565 0.3055625842188923 0.14709936575823207 8.53260706657325 0.08161482159894216 0.12214475035326997 1.1801271235183178e-06 5.928071207889761 -0.725420007231202 SNDRNS(ph)MDIQCEVDALLER ddPTM_A459_Selumetinib_30min_R1 6 SNDRNSMDIQCEVDALLER 19 1 Q02241;H7BYN4;A0A2U3TZL8;A0A2R8Y531;H0YME6;Q02241-2 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 S(0.079)NDRNS(0.921)MDIQCEVDALLER;S(0.031)NDRNS(0.969)MDIQCEVDALLER;S(0.348)NDRNS(0.652)MDIQCEVDALLER;S(0.005)NDRNS(0.995)MDIQCEVDALLER;S(0.058)NDRNS(0.942)MDIQCEVDALLER;S(0.015)NDRNS(0.985)MDIQCEVDALLER 158.89 1.2725e-06 65378100.0 3804.4199999999996 5141.65 4971.55 5783.51 4969.86 5047.95 4707.2 4505.32 2307.72 3919.9999999999995 True False 3893.0555838873215 4539.663227711762 4296.440816769384 4773.528548428491 4520.337040500047 4997.172206171882 4352.132114211538 4385.824278258162 3916.0322907999084 4423.170184033475 0.8801505304815688 1.0263370023832221 0.9713487471674609 1.079209786152864 1.0219676956625634 1.1297716339765558 0.983939557632585 0.9915567558512393 0.8853451546892303 1.0 12.11086503649344 -7.894298178646338 2.819092368313273 0.9429191139436339 1.020141863245231 0.13522861580564582 0.06760960612370195 0.4828048693111254 7.5051236074089775 0.04621527961990667 0.01855076400083506 1.2755627300604863e-08 7.894298178646338 0.07722274930159712 SNDRNS(ph)MDIQCEVDALLER ddPTM_A459_Selumetinib_30min_R2 3 SNDRNSMDIQCEVDALLER 19 1 Q02241;H7BYN4;A0A2U3TZL8;A0A2R8Y531;H0YME6;Q02241-2 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 S(0.007)NDRNS(0.993)MDIQCEVDALLER;S(0.033)NDRNS(0.967)MDIQCEVDALLER;S(0.345)NDRNS(0.655)MDIQCEVDALLER 97.825 0.00083007 7982300.0 15931.0 13269.2 15633.899999999998 17009.5 14152.400000000001 13351.6 15178.3 17389.6 12867.6 14353.0 True False 15045.618796845902 14286.904972797241 14628.031894903279 14692.776756975858 12374.448987938722 15190.661706242614 15884.121025230863 17440.200856996747 15441.479550783799 13938.591596427443 1.0794217401923303 1.0249891370989788 1.0494626945417171 1.0541077020107052 0.887783310267185 1.0898275913425919 1.1395786235176066 1.2512168633642147 1.1078220811593014 1.0 13.766797173216245 -6.994571420332015 24.9636925848943 1.1411768574240684 1.0196732043673442 0.30048500239340536 0.07498069259711118 154.695163865374 711370.7570898265 0.026207381659569116 0.0230433476586088 1.012578215224731e-07 6.994571420332015 -0.12150365305672417 SNDS(ph)TDGEPEEK ddPTM_A459_Selumetinib_30min_R1 1 SNDSTDGEPEEK 12 0 A0A0A0MTH9;O14981 A0A0A0MTH9 BTAF1 TATA-binding protein-associated factor 172 1 SNDS(0.952)T(0.047)DGEPEEK 106.76 0.0087674 2998100.0 1458.1 1573.8 1345.3 2010.1 1437.6 1590.6 1276.0 1236.4 910.23 1087.2 True False 1492.070893031291 1389.5387643602287 1162.615649203941 1659.073769250182 1307.569333828895 1574.6000081492473 1179.750292686506 1203.6066556067929 1544.5938294311281 1226.752710224794 1.2162768262870838 1.1326967144874742 0.9477180197065956 1.3524109263603485 1.065878496073827 1.283551277307317 0.9616854993296284 0.981132257198144 1.259091434285963 1.0 10.260628743370898 -7.273794112190796 24.98411831090486 1.0489049957161214 1.1588318654332888 0.15882671691174133 0.12999637553912405 1578.9504510736574 3192987.482783499 0.05280882848324582 0.03589866750321799 5.323605778684246e-08 7.273794112190796 0.10992686971716736 SNDS(ph)TDGEPEEK ddPTM_A459_Selumetinib_30min_R2 1 SNDSTDGEPEEK 12 0 A0A0A0MTH9;O14981 A0A0A0MTH9 BTAF1 TATA-binding protein-associated factor 172 1 S(0.013)NDS(0.934)T(0.053)DGEPEEK 88.78 0.031017000000000006 0.0 14614.0 15975.0 14912.0 17902.0 15966.0 13127.0 13066.0 13970.0 12241.0 14121.0 True False 13801.812384477169 17200.231132278957 13952.578154957992 15463.716717327494 13960.208342149008 14935.125094958417 13673.59488978782 14010.650387142 14689.542042116984 13713.290039235828 1.006455222998133 1.2542745820343955 1.0174493586176274 1.1276445457715418 1.0180057668296016 1.0890986081550622 0.9971053518641819 1.0216840996621073 1.071190210378979 1.0 13.743287117979543 -6.195747556626214 1.0272954977185154 1.0290160334646696 1.1178804797156288 0.1646958509056058 0.07005558268146045 0.8695735970066061 1.91593526207421 0.029045673533709307 0.04828452129339731 6.371657801366809e-07 6.195747556626214 0.08886444625095913 SNEDQSMGNWQIK ddPTM_A459_Selumetinib_30min_R1 4 SNEDQSMGNWQIK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;; 234.24 2.0854e-11 43627000.0 5397.0 5295.799999999999 5405.4 5527.33 5058.92 5288.2 6010.000000000001 5195.92 3026.66 5025.62 False True 5522.739599266086 4675.765274049373 4671.376369736847 4562.085576334313 4601.341579224872 5235.005509301432 5556.660861321241 5058.1073228732175 5136.020961499856 5670.7072806842625 0.9739066620627398 0.8245471054335864 0.8237731447801286 0.804500276689264 0.8114228704588761 0.9231662383867121 0.9798885017832802 0.8919711550095872 0.9057108235853274 1.0 12.469312971628323 -6.850194725534968 6.233647364358779 0.9372600623182981 0.8428485978348705 0.422514003217652 0.054042589965264724 0.21809895249007066 12.456265354924403 0.01944210516037584 0.017188165602322926 1.4119043441430334e-07 6.850194725534968 -0.09441146448342752 SNEDS(ph)LILEK ddPTM_A459_Selumetinib_30min_R1 2 SNEDSLILEK 10 0 A0A0U1RRH6;O94880 A0A0U1RRH6 PHF14 PHD finger protein 14 1 S(0.01)NEDS(0.99)LILEK;S(0.103)NEDS(0.897)LILEK 127.3 0.0033107 7302700.0 3623.0 4250.6 4145.1 4279.0 3891.0 3134.1 3868.7 3702.4 2303.2 3455.5 True False 3707.4088508691925 3752.9377759496697 3582.218187404488 3531.7529767780334 3539.059737011845 3102.573799535119 3576.880844291759 3604.2003249098907 3908.3621809276465 3899.0470844203246 0.9508499822131224 0.9625269186785476 0.9187419669072964 0.9057990068624941 0.9076729930123428 0.7957261690766122 0.9173730829217563 0.9243797899521213 1.0023890700229148 1.0 11.928905861313398 -8.199333542951061 3.197288519196292 1.0041911953895541 0.9069943711443019 0.4303206408806268 0.042053124649454834 0.26295943304321906 4.979979740700706 0.03945021383967333 0.012122553153235066 6.319263385642267e-09 8.199333542951061 -0.09719682424525222 SNEDS(ph)LILEK ddPTM_A459_Selumetinib_30min_R2 1 SNEDSLILEK 10 0 A0A0U1RRH6;O94880 A0A0U1RRH6 PHF14 PHD finger protein 14 1 SNEDS(1)LILEK 140.33 0.0014302999999999998 7585000.0 19814.0 21382.0 22917.0 25248.0 22029.0 20487.0 20276.0 22037.0 16827.0 23883.0 True False 18712.817201726477 23021.93064603373 21442.545170143007 21809.178844770653 19261.520078241298 23308.898287530534 21218.874176131787 22101.12402157826 20192.87018566315 23193.435734513787 0.8068152306508098 0.9926054470565202 0.9245092195734801 0.9403168678591571 0.8304729104700315 1.004978242738092 0.9148654998343482 0.9529042731987277 0.8706286734230779 1.0 14.501428927433226 -6.778211177698963 24.999464226828668 0.9436187013840528 0.9078661054874485 0.129890101089285 0.06155985604203026 701.3679295662205 1045427.8044330674 0.02092360116980704 0.018500470238576518 1.6664367029615892e-07 6.778211177698963 -0.03575259589660429 SNEEEET(ph)SDSSLEK ddPTM_A459_Selumetinib_30min_R2 2 SNEEEETSDSSLEK 14 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 SNEEEET(0.48)S(0.48)DS(0.02)S(0.02)LEK;SNEEEET(0.489)S(0.489)DS(0.011)S(0.011)LEK 133.23 0.0017384 12085000.0 39739.0 30505.0 40084.0 42671.0 40042.0 27619.0 29545.0 33305.0 25391.0 35104.0 True False 37530.46546782115 32844.63541096526 37505.039080159346 36859.13618841923 35011.56597997811 31423.266549680564 30918.901042306847 33401.91203606044 30469.909483816064 34090.45630885451 1.1009082755537405 0.9634554349580335 1.1001624249428994 1.0812156884754163 1.027019575883012 0.9217613945964935 0.9069664765465782 0.9798024330752291 0.8937958825708631 1.0 15.057080289972326 -6.653569785990456 4.390453318651318 0.9372570913126794 1.056805621594725 0.6005810357702259 0.046988489976824754 0.14931574002446982 5.044025106649689 0.015479579963640676 0.015349397099484364 2.220394863570706e-07 6.653569785990456 0.1195485302820456 SNEEGS(ph)EEKGPEVR ddPTM_A459_Selumetinib_30min_R1 1 SNEEGSEEKGPEVR 14 1 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 1 SNEEGS(1)EEKGPEVR 163.34 0.0012760999999999998 4995300.0 1979.9 2436.7 2718.6 2882.6 2019.8 2443.0 1941.3 2187.6 1495.8 2364.9 True False 2026.0278177852354 2151.4100312089017 2349.429052200871 2379.208023103613 1837.1094466246523 2418.4256380665247 1794.8661780504028 2129.5777416737465 2538.2633510904734 2668.457951076727 0.7592504191297936 0.8062371866646069 0.8804444721539916 0.8916040899739862 0.6884535864180943 0.9063008233240798 0.6726229946123645 0.7980555739371716 0.9512097989276092 1.0 11.381790562523433 -8.34464217203104 3.877011343801687 0.9940320938116675 0.8016200748444471 0.46796231717978 0.07539893900573927 0.20147706643477245 5.347567270485615 0.07042398697586194 0.018866006070769846 4.522283951636893e-09 8.34464217203104 -0.19241201896722038 SNEEGS(ph)EEKGPEVR ddPTM_A459_Selumetinib_30min_R2 1 SNEEGSEEKGPEVR 14 1 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 1 S(0.001)NEEGS(0.999)EEKGPEVR 66.26100000000001 0.03831 4254300.0 19586.0 17837.0 14472.0 14421.0 12686.0 11746.0 13113.0 11172.0 6604.5 14701.0 True False 18497.488528970167 19205.040545005308 13540.88727592221 12456.834922387423 11092.27126572105 13363.904880428254 13722.780482916556 11204.50867037584 7925.584545148409 14276.543932214847 1.295655910617892 1.3452163658229195 0.9484709562912746 0.8725385486524317 0.776957736997641 0.9360742308418752 0.9612116593534427 0.7848194019207271 0.5551472809371198 1.0 13.80135915336198 -5.358683943180334 3.0463422545058156 0.8402941668664821 1.330244361094075 0.7140325152919833 0.11928560476944967 0.1363689697419911 2.4012239246365406 0.03346873882179615 0.08482226327092118 4.378406267610153e-06 5.358683943180334 0.489950194227593 SNEEGSEEKGPEVR ddPTM_A459_Selumetinib_30min_R1 3 SNEEGSEEKGPEVR 14 1 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 0 ;; 149.35 0.0012454 48394000.0 10009.0 11369.1 12639.3 13101.8 11268.8 10988.5 10999.900000000001 10602.4 6897.799999999999 8882.1 False True 10242.190225876271 10038.000486648802 10922.95248270525 10813.816581245721 10249.539029668224 10877.965666759726 10170.168686929706 10321.189910551162 11705.06280462084 10022.204053980546 1.0219498795585142 1.0015761435890922 1.089875283308261 1.0789858720698038 1.022683131820429 1.085386568480343 1.0147636819358505 1.0298323457555094 1.1679130400435132 1.0 13.290912196274009 -5.246950676470365 24.519601474442204 1.060713263723843 1.0117630044671804 0.15258710354652583 0.04657231798510781 1140.1800650874795 1929544.5150535973 0.01141512962951388 0.02988376347268027 5.663036014058833e-06 5.246950676470365 -0.04895025925666263 SNES(ph)VDIQDQEEK ddPTM_A459_Selumetinib_30min_R1 2 SNESVDIQDQEEK 13 0 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SNES(1)VDIQDQEEK;SNES(1)VDIQDQEEK 248.25 8.831399999999998e-23 9676900.0 5254.5 4977.0 5568.7 5940.9 5090.7 4959.0 5110.1 5802.3 2137.21 4302.299999999999 True False 5376.919626522816 4394.290526255474 4812.501126679538 4903.4333395047 4630.247083836086 4909.116962411746 4724.641042834888 5648.404155473381 3626.6892743575813 4854.54211295082 1.1076059289254923 0.9051915554574139 0.9913398657807239 1.0100712333761506 0.9537968723113214 1.0112420179269497 0.973241334178689 1.1635297467921262 0.7470713385475418 1.0 12.245119509754938 -8.269594851454666 24.99947151810884 0.8735357079624725 1.0064312858692377 0.2778334090427661 0.09016002034537954 872.0921688058933 2673243.591660057 0.07567369489647364 0.020851858190654115 5.37533021183445e-09 8.269594851454666 0.1328955779067652 SNES(ph)VDIQDQEEK ddPTM_A459_Selumetinib_30min_R2 2 SNESVDIQDQEEK 13 0 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 S(0.002)NES(0.998)VDIQDQEEK;S(0.112)NES(0.888)VDIQDQEEK 146.2 0.00077874 3967900.0 23018.0 25523.0 27600.0 30582.0 28514.0 17021.3 18163.4 23046.0 18066.8 24832.0 True False 21738.751708354695 27480.532030620092 25824.246048607874 26416.678843107413 24931.81640160573 19365.829571022765 19008.034090094312 23113.060044529328 21680.6648285695 24115.03563871566 0.9014604844064198 1.1395600836890853 1.070877374410683 1.095444321081432 1.0338701868463658 0.80306037532583 0.7882233464161971 0.9584501715362301 0.8990517432104524 1.0 14.55764532175626 -6.656518870816016 6.5366782148680675 0.8813603655635553 1.0597229451166965 0.4774838594353783 0.08254739794285473 0.17561196386712305 9.652481358102413 0.02730054903506676 0.027221922560357686 2.2053683073977023e-07 6.656518870816016 0.17836257955314117 SNFS(ph)NSADDIK ddPTM_A459_Selumetinib_30min_R1 1 SNFSNSADDIK 11 0 P45973 P45973 CBX5 Chromobox protein homolog 5 1 S(0.156)NFS(0.844)NSADDIK 201.3 1.8773e-05 24052000.0 2668.7 2936.7 2873.6 2584.0 2468.6 2370.0 2637.6 2705.4 1704.0 2316.5 True False 2730.8755176137483 2592.8697987652076 2483.3809035549275 2132.7529076874116 2245.315565866728 2346.159951787828 2438.643708456056 2633.644003622304 2891.563544764114 2613.845339620802 1.044773183867843 0.9919752173023989 0.9500871631200638 0.8159445684712227 0.8590085770692394 0.8975894312584662 0.9329716917412708 1.0075745353795011 1.1062489049882351 1.0 11.35195806452414 -7.866835799920737 3.282679894459163 1.0544771860789353 0.9221287474203189 0.3859261279613433 0.06515545138578989 0.2688221459759723 5.611783690634067 0.0457896527372766 0.019709526645882644 1.3588271011540259e-08 7.866835799920737 -0.13234843865861634 SNGELSES(ph)PGAGK ddPTM_A459_Selumetinib_30min_R1 2 SNGELSESPGAGK 13 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;A0A0A0MR81;F5H176 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 SNGELS(0.001)ES(0.999)PGAGK;SNGELS(0.044)ES(0.956)PGAGK 184.87 0.00012445 67928000.0 10961.1 14206.0 14514.4 15236.2 12888.5 12263.1 12450.9 10727.7 6450.200000000001 10419.099999999999 True False 11216.472303412174 12542.754915809775 12543.424201892278 12575.483688895885 11722.737450649487 12139.744348003931 11511.718588722897 10443.166547519408 10945.518296031396 11756.492975628365 0.9540661765940172 1.0668789529166018 1.066935881975624 1.0696628420537755 0.9971287759837177 1.0325991240049273 0.9791796424824227 0.8882892686763365 0.931018996797927 1.0 13.521170140298384 -7.442919792427553 3.329518327312182 0.9319010962318874 1.03467141321568 0.4804838816802315 0.042420424858169006 0.1940165905918385 4.135597373957827 0.020038232995651606 0.012289003055001906 3.6064524255179865e-08 7.442919792427553 0.10277031698379258 SNGELSES(ph)PGAGK ddPTM_A459_Selumetinib_30min_R2 3 SNGELSESPGAGK 13 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;A0A0A0MR81;F5H176 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 SNGELS(0.001)ES(0.999)PGAGK;S(0.002)NGELS(0.143)ES(0.855)PGAGK;SNGELS(0.054)ES(0.946)PGAGK 156.72 0.00036515 76487000.0 327400.0 266720.0 292094.0 329754.0 312352.0 250814.0 292341.0 299124.0 222416.0 299470.0 True False 309204.418686043 287176.5663600275 273300.9900479016 284840.93634262076 273111.5492976908 285361.3518371986 305935.4357627016 299994.40131735615 266905.4148222764 290823.52298349695 1.063202919468069 0.9874598980644478 0.9397485706938854 0.979428807616722 0.9390971765141184 0.9812182622290553 1.05196248441039 1.0315341697252585 0.917757312352695 1.0 18.149784439427265 -7.033404773535711 24.738813525547723 1.004891200739511 0.9776882242401382 0.030845067780825963 0.045696560602234294 1703.0582864938972 1261241.4393002952 0.017831909576287715 0.01382376650486964 9.259663967714328e-08 7.033404773535711 -0.027202976499372755 SNGVTPGTQS(ph)SPAPSTR ddPTM_A459_Selumetinib_30min_R2 1 SNGVTPGTQSSPAPSTR 17 0 Q8TDW5;Q8TDW5-2 Q8TDW5 SYTL5 Synaptotagmin-like protein 5 1 SNGVTPGT(0.128)QS(0.436)S(0.436)PAPSTR 78.501 0.018719 1415200.0 9713.3 6877.1 8238.4 5935.2 5699.1 5609.7 5211.2 6514.1 4551.8 7041.6 True False 9173.4736714207 7404.551456638224 7708.350313291706 5126.81552120892 4983.128107399563 6382.385255213553 5453.531125796901 6533.054952532696 5462.2871879183185 6838.290711726009 1.3414863535547585 1.0828073518344599 1.1272334912690616 0.7497217853604373 0.7287096026576799 0.9333304950415915 0.7974991640009422 0.9553637345850319 0.7987796100203551 1.0 12.739420041076317 -5.656915754776642 5.171276662591953 0.8466418202603408 1.186392071380733 0.6863223308186732 0.10331728515151216 0.11653638909373469 4.854557938399755 0.027963471143369136 0.04919376988652383 2.2033538321335976e-06 5.656915754776642 0.33975025112039214 SNLDEEVNVIPPHT(ph)PVR ddPTM_A459_Selumetinib_30min_R1 3 SNLDEEVNVIPPHTPVR 17 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 SNLDEEVNVIPPHT(1)PVR;SNLDEEVNVIPPHT(1)PVR;SNLDEEVNVIPPHT(1)PVR 200.94 1.1348e-07 36812100.0 6160.6 9262.8 7300.1 6815.0 8219.0 7511.2 9615.3 8588.199999999999 3813.0600000000004 8018.2 True False 6304.129993559133 8178.307069841112 6308.78651657897 5624.888183393854 7475.592901182311 7435.644147623938 8890.010179677562 8360.413037594837 6470.484325116353 9047.414073881937 0.696788048173664 0.903938628546939 0.6973027281675066 0.6217122525243731 0.8262684608149905 0.8218529722309433 0.9826023333386753 0.9240665862447555 0.7151749961124625 1.0 13.143289785599434 -6.737950824759763 2.460228572088175 0.8964936668962625 0.7408831048750105 0.35225056331927784 0.1009376373733916 0.35248388296726374 4.373771298165366 0.03872756982364341 0.036347779081984395 1.8283072239698867e-07 6.737950824759763 -0.155610562021252 SNLDEEVNVIPPHT(ph)PVR ddPTM_A459_Selumetinib_30min_R2 3 SNLDEEVNVIPPHTPVR 17 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 SNLDEEVNVIPPHT(1)PVR;SNLDEEVNVIPPHT(1)PVR;SNLDEEVNVIPPHT(1)PVR 161.97 2.484e-05 79300900.0 183467.0 149884.0 210752.0 224625.0 266702.0 190537.0 208786.0 231041.0 193744.0 200265.0 True False 173270.63861659178 161379.62084697984 197192.44576942784 194030.687500262 233196.51041386867 216781.7422273246 218494.96270161032 231713.29105910324 232498.21365966115 194482.8290990415 0.890930265768361 0.8297885298901958 1.0139324210931056 0.9976751592884879 1.199059636751335 1.1146574904920128 1.1234665996674724 1.1914331570171777 1.1954691050964716 1.0 17.56928325963694 -5.706593728936865 1.3492977649012206 1.1451877574527853 0.8539467439670692 0.7166661881188572 0.06583606050110978 0.22382023195570272 0.802189043119218 0.021040706716845804 0.05560439713516965 1.9651978080733233e-06 5.706593728936865 -0.2912410134857162 SNNWS(ph)LEDVTASDK ddPTM_A459_Selumetinib_30min_R1 2 SNNWSLEDVTASDK 14 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 SNNWS(0.996)LEDVT(0.003)AS(0.001)DK;SNNWS(1)LEDVTASDK 140.75 0.00055993 18116900.0 2999.13 4312.4 3230.6 3842.5 4311.9 3537.2 4751.5 4065.5 2155.5299999999997 3464.0 True False 3069.003893708892 3807.502203219631 2791.9022644155575 3171.4795076582354 3921.889406327777 3501.6189795206324 4393.090529545404 3957.6697333948664 3657.7769763177193 3908.638142217334 0.7851849626499 0.9741250186592281 0.7142902880315591 0.811402691234826 1.0033902509335197 0.8958667577076338 1.1239440361837243 1.0125444181306886 0.9358187796434634 1.0 11.932450312217593 -6.262873796384629 24.851603879597466 0.9973524025511287 0.8245302937101588 0.5214171424659324 0.08163164762821785 99.92592616992552 1731234.141699983 0.024966515601491674 0.029865359589937725 5.459164784042039e-07 6.262873796384629 -0.17282210884096982 SNNWS(ph)LEDVTASDK ddPTM_A459_Selumetinib_30min_R2 2 SNNWSLEDVTASDK 14 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 SNNWS(0.975)LEDVT(0.025)ASDK;SNNWS(0.998)LEDVT(0.002)ASDK 228.32 3.4566e-13 14740700.0 45461.0 35028.0 42801.0 52910.0 47631.0 42519.0 53568.0 52321.0 42447.0 43456.0 True False 42934.459614802036 37714.53496722802 40047.2302582053 45703.56672515906 41647.1679534573 48375.60630094745 56059.01814297826 52473.24544779218 50937.58606827384 42201.31236775245 1.017372617246136 0.8936815670227133 0.9489569876221868 1.0829892285549585 0.9868690241320885 1.1463057328499813 1.328371441496094 1.243403166956696 1.2070142659164576 1.0 15.365000243813865 -6.852350808416495 3.5481156317005085 1.2177287159459396 0.9826389606565754 0.546911577174968 0.09018462500776686 0.1626597345222635 4.001783274461876 0.032726114999915554 0.029011358262094198 1.4049122250115741e-07 6.852350808416495 -0.23508975528936416 SNPTPMEPT(ph)SPGEHQQNSK ddPTM_A459_Selumetinib_30min_R1 2 SNPTPMEPTSPGEHQQNSK 19 0 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 SNPTPMEPT(0.754)S(0.246)PGEHQQNSK;SNPT(0.01)PMEPT(0.495)S(0.495)PGEHQQNSK 154.66 8.2015e-06 15600900.0 3518.8999999999996 3593.7 3922.3999999999996 4085.5 3970.3 3216.3 3723.5 3539.5 1783.1100000000001 2817.3 True False 3600.88352341253 3172.9479333341947 3389.7596242009495 3372.0441193331744 3611.1870660133973 3183.9469421667454 3442.6333971929535 3445.620962083662 3025.807436798322 3178.927897825896 1.1327351985162086 0.9981188738203874 1.0663216446397679 1.060748852353447 1.1359763989875733 1.0015788481218093 1.0829542247710018 1.0838940274298643 0.9518326725396024 1.0 11.634324579329647 -8.258424034181434 24.983939470649407 0.9759163314472175 1.0677561029651892 0.4175375466617465 0.044505827686425255 232.85684682265307 1929404.7368134144 0.031463358518122174 0.010739800151193022 5.515386678538455e-09 8.258424034181434 0.09183977151797174 SNPTPMEPT(ph)SPGEHQQNSK ddPTM_A459_Selumetinib_30min_R2 1 SNPTPMEPTSPGEHQQNSK 19 0 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 SNPT(0.002)PMEPT(0.98)S(0.018)PGEHQQNSK 92.428 0.0030548000000000003 6880700.0 23700.0 18217.0 25158.0 25196.0 25300.0 20962.0 22021.0 23208.0 20839.0 23205.0 True False 22382.848878617013 19614.18532311273 23539.361669959304 21764.26133447567 22121.58781513029 23849.325225909844 23045.020133783688 23275.531437708774 25007.382290309277 22535.011356169358 0.9932477301587563 0.870387194978848 1.044568440544184 0.9657976643760295 0.9816541676192284 1.0583231953588819 1.0226318402752748 1.0328608701293902 1.1097124334691344 1.0 14.459880556626688 -6.239456339588117 0.7156349988800208 1.0514761595200288 0.9418489249600036 0.34752786883012565 0.04896185406933609 0.8335419820192926 0.911369905316399 0.02860238235555766 0.053138930461371 5.761607381323311e-07 6.239456339588117 -0.10962723456002521 SNPTPMEPTS(ph)PGEHQQNSK ddPTM_A459_Selumetinib_30min_R2 2 SNPTPMEPTSPGEHQQNSK 19 0 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 SNPTPMEPT(0.005)S(0.995)PGEHQQNSK;SNPTPMEPT(0.011)S(0.989)PGEHQQNSK 136.96 0.00011105 21525000.0 84056.0 81662.0 90942.0 92695.0 93019.0 68252.0 77039.0 82377.0 67903.0 90813.0 True False 79384.50402282827 87925.21281528429 85090.8907301631 80069.78109220607 81333.12161958903 77653.0934700315 80621.46614988253 82616.70343175349 81485.49736834162 88190.99272948972 0.9001429915447965 0.9969863145205694 0.964847861404218 0.9079133663661773 0.9222384180328257 0.8805104814753434 0.9141689378321732 0.9367929861631745 0.9239662106796322 1.0 16.428343695104637 -3.789610816981831 12.103611510717833 0.9323933630634774 0.9378301725661795 0.0 0.03827926000644421 0.0 0.0 0.008870237618546823 0.0 0.0001623264096588821 3.789610816981831 0.005436809502702089 SNQSLGWGDS(ph)SKPVSSPDWNK ddPTM_A459_Selumetinib_30min_R2 1 SNQSLGWGDSSKPVSSPDWNK 21 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 S(0.009)NQS(0.066)LGWGDS(0.561)S(0.172)KPVS(0.096)S(0.096)PDWNK 56.017 0.017075999999999997 18857000.0 38157.0 25678.0 33770.0 35730.0 31782.0 24152.0 27364.0 37150.0 26429.0 33100.0 True False 36036.3866945734 27647.42003221652 31597.274965995934 30863.5123623121 27789.261025315045 27478.718769973024 28636.480220737343 37258.10034948641 31715.538487959304 32144.316995871817 1.1210811136289325 0.8601028927062654 0.9829816875578306 0.9601545544201731 0.8645155231913598 0.8548546473549903 0.8908722566547308 1.1590882566977965 0.9866608300320215 1.0 14.972276076151076 -7.740856658201982 24.999850620828482 1.0546559801588689 0.9279345008433074 0.26755504512961115 0.08673411469839748 275.9429070180565 335162.0431569706 0.03999411320693808 0.023057471381010556 1.8161149847582414e-08 7.740856658201982 -0.12672147931556144 SNQSLGWGDSSKPVS(ph)SPDWNK ddPTM_A459_Selumetinib_30min_R1 2 SNQSLGWGDSSKPVSSPDWNK 21 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 SNQSLGWGDSSKPVS(0.579)S(0.42)PDWNK;SNQSLGWGDS(0.007)S(0.007)KPVS(0.493)S(0.493)PDWNK 83.06299999999997 0.00079012 66923000.0 6717.299999999999 7341.3 5548.7 6874.3 6548.4 6229.4 6955.0 7213.3 3980.0 6660.0 True False 6873.800020409503 6481.7771831222235 4795.2170168274015 5673.83255159272 5956.098376213919 6166.737891842654 6430.378750497373 7021.979851899445 6753.769312301163 7514.8758738936085 0.9146924228367925 0.862526180324504 0.6380966362313185 0.7550134755124029 0.792574418548306 0.8206040918474337 0.8556866218956807 0.9344106236396444 0.8987200089044052 1.0 12.875533559449494 -7.715263793431906 1.0179516662460932 0.9706987790370459 0.7852876941992533 0.4740687608621815 0.0704552424709993 0.5112167901426955 0.9603927343781237 0.06590896731338845 0.0273584542880207 1.926354476906834e-08 7.715263793431906 -0.18541108483779267 SNQSLGWGDSSKPVS(ph)SPDWNK ddPTM_A459_Selumetinib_30min_R2 1 SNQSLGWGDSSKPVSSPDWNK 21 1 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 1 SNQS(0.001)LGWGDS(0.004)S(0.004)KPVS(0.495)S(0.495)PDWNK 49.326 0.037593 23786000.0 49719.0 29235.0 38836.0 37547.0 34946.0 37882.0 32999.0 43572.0 29698.0 44195.0 True False 46955.81702092656 31477.230494658874 36337.33404143969 32433.033827812273 30555.771058796152 43099.90164144246 34533.51888627801 43698.78730626709 35638.42983145087 42918.97551759983 1.0940572661542525 0.733410574577927 0.8466496136781922 0.7556805221157347 0.7119408301408806 1.0042155275530387 0.8046212303487258 1.0181693942891876 0.830365343106491 1.0 15.389328018707298 -6.7711761891341595 24.999987731251125 0.9246815504109244 0.8200531651936583 0.15375339750999273 0.11965502226314634 388.29971015646476 996982.6515687079 0.04031558906554894 0.03598734502692081 1.6936505631544177e-07 6.7711761891341595 -0.10462838521726603 SNRAASAAGAAGSAGGSSGAAGAAGGGAGAGT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 SNRAASAAGAAGSAGGSSGAAGAAGGGAGAGTR 33 1 Q9UKY7;Q9UKY7-2 Q9UKY7 CDV3 Protein CDV3 homolog 1 SNRAASAAGAAGS(0.004)AGGS(0.037)S(0.037)GAAGAAGGGAGAGT(0.923)R 54.324 0.0018547 10636000.0 865.38 2226.2 472.69 1542.4 11872.0 559.79 3119.2 756.43 84.962 147.81 True False 885.541670263644 1965.5554690676984 408.5012943003129 1273.0487944338488 10798.179696171834 554.1590208486531 2883.9162327176728 736.3670191690761 144.17430862103805 166.78285329132348 5.309548630378975 11.785117176490662 2.4493003101870086 7.632971671315546 64.7439438951821 3.322637848632381 17.291443189788037 4.415124244713854 0.8644432312787301 1.0 7.381827164749485 -6.01634732414831 24.965136099052813 9.999999999999998 6.708264816115151 0.001954882591799212 18.265186975509845 7444.064628567545 11368361.955963781 5.717830482478302 7.594917452190461 9.630585158628114e-07 6.01634732414831 -3.291735183884847 SNS(ph)APLIHGLSDTSPVFQAEAPSAR ddPTM_A459_Selumetinib_30min_R1 2 SNSAPLIHGLSDTSPVFQAEAPSAR 25 0 Q96E09 Q96E09 FAM122A Protein FAM122A 1 S(0.253)NS(0.747)APLIHGLSDTSPVFQAEAPSAR;S(0.239)NS(0.761)APLIHGLSDTSPVFQAEAPSAR 190.09 8.013400000000001e-27 111159000.0 4162.7 5235.4 4528.4 4872.3 5079.700000000001 4222.2 5157.9 4658.8 1695.9299999999998 3833.4 True False 4259.682810795798 4622.436934128572 3913.468152720675 4021.4442693983665 4620.242031893875 4179.728501450869 4768.835450350888 4535.233490084865 2877.8693441735945 4325.454230478038 0.9847943322995303 1.0686593101732376 0.9047531066553832 0.9297160610468249 1.0681518716204883 0.966309728120493 1.1025051234500864 1.0484987814987565 0.6653334403345519 1.0 12.078635927619175 -8.229574013302853 24.993888773736327 0.8326665200135711 1.008675349196487 0.34912777049543764 0.09639807910307382 597.141617698235 468374.81814206694 0.06194085480746904 0.023407384920867778 5.894215181541035e-09 8.229574013302853 0.17600882918291594 SNS(ph)APLIHGLSDTSPVFQAEAPSAR ddPTM_A459_Selumetinib_30min_R2 4 SNSAPLIHGLSDTSPVFQAEAPSAR 25 0 Q96E09 Q96E09 FAM122A Protein FAM122A 1 S(0.235)NS(0.765)APLIHGLSDTSPVFQAEAPSAR;S(0.257)NS(0.743)APLIHGLSDTSPVFQAEAPSAR;S(0.172)NS(0.828)APLIHGLSDTSPVFQAEAPSAR;S(0.24)NS(0.76)APLIHGLSDTSPVFQAEAPSAR 137.51 2.3301e-08 218769000.0 207449.0 173771.0 228065.0 287440.0 256524.0 197740.0 174793.0 213990.0 178337.0 232371.0 True False 195919.81506414438 187098.67693816873 213391.54619839665 248290.17613834306 224297.16176634294 224976.89009500097 182921.2208457588 214612.6754720483 214009.38315211268 225661.84545763556 0.8682008899946058 0.8291108164906572 0.9456252817823274 1.10027539496018 0.9939525280025736 0.9969646824378063 0.810598798723816 0.9510366053987555 0.9483631702032215 1.0 17.783802985025552 -5.338331909313586 5.352760841912174 0.9685913002071543 0.849052731215179 0.333373405142696 0.06814921008156676 0.25367061721798795 12.80507078748096 0.019589442875480242 0.04236300752499465 4.588472050831589e-06 5.338331909313586 -0.11953856899197535 SNS(ph)DESNFSEK ddPTM_A459_Selumetinib_30min_R1 1 SNSDESNFSEK 11 0 O95999;A0A087WWW9 O95999 BCL10 B-cell lymphoma/leukemia 10 1 S(0.012)NS(0.987)DESNFSEK 206.66 1.7565e-05 10482000.0 2146.2 2442.9 2203.4 2529.9 2301.2 2089.8 2393.2 2453.7 1338.4 1925.8 True False 2196.202284221766 2156.884132326601 1904.1903824098436 2088.1004571046383 2093.056866309859 2068.778509386583 2212.6789972236256 2388.6199052591282 2271.167047131626 2172.995188880527 1.0106797729971941 0.9925857836057952 0.8762975602310629 0.9609319283308563 0.9632128395959079 0.9520400781247778 1.0182622624045212 1.0992292654314093 1.0451781295943294 1.0 11.085469264986212 -7.419229748532731 3.777460938178534 1.055070873450012 0.9574588676536596 0.5041152131087843 0.03996339819274423 0.18700186090157161 4.800445582292189 0.018621054566488455 0.01182238905295577 3.808642869615711e-08 7.419229748532731 -0.09761200579635243 SNS(ph)DVTISDIDAEDVLDQNAVNPNTGAALHR ddPTM_A459_Selumetinib_30min_R1 2 SNSDVTISDIDAEDVLDQNAVNPNTGAALHR 31 0 Q9P2F8 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 S(0.143)NS(0.851)DVT(0.005)ISDIDAEDVLDQNAVNPNTGAALHR;S(0.166)NS(0.831)DVT(0.003)ISDIDAEDVLDQNAVNPNTGAALHR 237.56 1.0078999999999998e-66 53925000.0 3330.6 3690.1000000000004 3901.2 4379.1 3970.1000000000004 3079.7 3593.8999999999996 3273.2 1677.5 2718.8 True False 3408.1964997805467 3258.061376519051 3371.4384677576845 3614.372390887753 3611.005155978085 3048.721014143871 3322.809229534508 3186.3841031479715 2846.594980247539 3067.7844633546442 1.1109634788532892 1.0620242117519356 1.0989815314701061 1.1781702508967697 1.1770726395913176 0.9937859228904473 1.083129949064607 1.0386597041643655 0.9278992752752803 1.0 11.582981410080302 -7.592862238906447 1.068924156076864 0.971833888412335 1.1157630869345543 0.5257515862731408 0.05231834778777318 0.452881030923909 0.9497494895036582 0.045369783839089156 0.020050545457866865 2.5535111649054847e-08 7.592862238906447 0.1439291985222193 SNS(ph)EVEDVGPTSHNR ddPTM_A459_Selumetinib_30min_R1 1 SNSEVEDVGPTSHNR 15 0 Q13206 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 S(0.23)NS(0.77)EVEDVGPTSHNR 137.86 0.00026456 9901200.0 1626.1 1942.3 2073.6 1952.0 1966.2 1823.5 1969.8 1906.5 1256.6 1330.0 True False 1663.9849661601968 1714.8946130492275 1792.0165094694805 1611.1198435781077 1788.3575571608037 1805.1572456055296 1821.216400104921 1855.9334268152293 2132.3584215672454 1500.718455297072 1.1087922323383472 1.1427157485777428 1.1941057319207453 1.0735656897477024 1.1916675981750304 1.202862028672922 1.2135630062231795 1.2366966103897492 1.4208917162580892 1.0 10.551437627879421 -6.7498830024328385 1.7132262968759053 1.2369488811035996 1.1353732119013038 0.12066206727888562 0.09985553373827975 0.6554018212117776 3.9817319177824557 0.04051294084790626 0.03727569294271305 1.778758537452443e-07 6.7498830024328385 -0.10157566920229577 SNS(ph)FIGVPNGEVEMPLK ddPTM_A459_Selumetinib_30min_R1 2 SNSFIGVPNGEVEMPLK 17 0 Q9H7E2-2;Q9H7E2;Q9H7E2-3 Q9H7E2-2 TDRD3 Tudor domain-containing protein 3 1 S(0.003)NS(0.997)FIGVPNGEVEMPLK;S(0.264)NS(0.736)FIGVPNGEVEMPLK 180.05 7.9126e-08 22089000.0 4611.8 4936.5 3946.7 4733.7 4710.1 4225.4 4857.4 4440.9 2421.33 4218.6 True False 4719.245966999319 4358.532285083413 3410.7598176712936 3907.0481575541435 4284.072286635694 4182.896312356236 4491.002407284826 4323.1129059238165 4108.820163053815 4760.098402643781 0.9914177329565765 0.915639114238198 0.716531367455963 0.8207914683831222 0.8999965807967961 0.8787415634166378 0.9434683965336731 0.9081982220205237 0.8631796688849451 1.0 12.216775682468164 -6.806241774306715 2.03012663927499 0.9194892834826337 0.8572849611503838 0.11913323920451047 0.07385105361087968 0.7777800903938995 6.593335953419549 0.032147763578740204 0.028642834629135014 1.5622776712846114e-07 6.806241774306715 -0.06220432233224993 SNS(ph)FIGVPNGEVEMPLK ddPTM_A459_Selumetinib_30min_R2 2 SNSFIGVPNGEVEMPLK 17 0 Q9H7E2-2;Q9H7E2;Q9H7E2-3 Q9H7E2-2 TDRD3 Tudor domain-containing protein 3 1 S(0.089)NS(0.911)FIGVPNGEVEMPLK;S(0.046)NS(0.954)FIGVPNGEVEMPLK 165.19 2.0956e-06 5207100.0 42270.0 40232.0 40394.0 43663.0 44573.0 37186.0 32328.0 40785.0 27348.0 35362.0 True False 39920.80262021694 43317.66503373064 37795.094017661846 37716.0240771238 38973.34125232421 42308.03395910139 33831.31605671675 40903.67759767976 32818.364166964726 34341.00717848999 1.1624819974768223 1.2613976290381872 1.1005819899579234 1.0982794966114973 1.1348922019018635 1.2319974699403011 0.9851579448696981 1.1911030269170555 0.9556610846149266 1.0 15.06764473193855 -7.932139270241093 0.6452344201400495 0.9858521384050575 1.1679475222307711 0.37351103000943886 0.07892990139477492 0.7910002475052335 0.6956003820568581 0.07384429129776718 0.036573512688487436 1.1691244142334234e-08 7.932139270241093 0.18209538382571366 SNS(ph)FNNPLGNR ddPTM_A459_Selumetinib_30min_R2 3 SNSFNNPLGNR 11 0 O95835;O95835-2 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 S(0.212)NS(0.788)FNNPLGNR;S(0.173)NS(0.827)FNNPLGNR;S(0.477)NS(0.523)FNNPLGNR 129.76 0.0025233 55444000.0 86353.0 74363.0 92666.0 100889.0 97200.0 69075.0 77163.0 71352.0 62207.0 75302.0 True False 81553.84595844797 80066.40298526837 86703.97044711218 87147.74415676772 84988.86702097482 78589.45424958132 80751.23239558381 71559.62250704049 74650.13820880417 73127.83560190735 1.115223023998824 1.094882712256563 1.1856493458812383 1.1917178108645496 1.1621958495207823 1.074685905889597 1.1042475376295373 0.9785551824150261 1.0208170061969823 1.0 16.158133042100296 -7.433659205850097 1.3879223534911214 0.9969048260059942 1.148496738127673 0.7357908979397111 0.03671975662824092 0.23366477345799017 0.8633702901153255 0.026443012471604167 0.013350492265275165 3.684179605902067e-08 7.433659205850097 0.15159191212167877 SNS(ph)FSDER ddPTM_A459_Selumetinib_30min_R2 1 SNSFSDER 8 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.211)NS(0.465)FS(0.323)DER 82.494 0.04118 10938000.0 146910.0 131220.0 172860.0 193490.0 170040.0 122200.0 155620.0 132520.0 115140.0 141560.0 True False 138745.33032732608 141284.1520611985 161738.37579573746 167136.32821113258 148678.0550231126 139031.94077884656 162856.63835517986 132905.61126013292 138171.21728039783 137472.7949829489 1.0092566339728164 1.0277244459801833 1.1765118750644321 1.215777479695986 1.0815089272139518 1.0113414861179701 1.1846463031131316 0.9667775451616994 1.0050804400793303 1.0 17.068786620881724 -7.782567685440066 24.99987582566837 0.9894466879254006 1.1012756158549002 0.34310422886123715 0.069962619685388 304.95465809242194 360829.5386958686 0.04079680683620803 0.01963053197882363 1.649803856901013e-08 7.782567685440066 0.11182892792949961 SNS(ph)GLGGEVSGVMSKPNVDPQPWFQDGPK ddPTM_A459_Selumetinib_30min_R1 2 SNSGLGGEVSGVMSKPNVDPQPWFQDGPK 29 1 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 S(0.143)NS(0.434)GLGGEVS(0.211)GVMS(0.211)KPNVDPQPWFQDGPK;S(0.234)NS(0.704)GLGGEVS(0.031)GVMS(0.031)KPNVDPQPWFQDGPK 85.44200000000002 2.4398e-06 38877000.0 1695.6999999999998 1911.44 2347.59 2250.7200000000003 1326.87 1629.3 1960.24 1435.79 981.16 1400.47 True False 1735.2065107421706 1687.6477161956518 2028.8001723888206 1857.6740032469868 1206.8548427779258 1612.9107212860358 1812.3775186017224 1397.7081850967945 1664.9568589088958 1580.233966233001 1.0980693668283799 1.0679733205701851 1.2838606280721343 1.1755689619021126 0.7637190875316108 1.0206784284803918 1.1469045453579958 0.8844944577597482 1.0536141447951908 1.0 10.625922461377735 SNS(ph)GLGGEVSGVMSKPNVDPQPWFQDGPK ddPTM_A459_Selumetinib_30min_R2 1 SNSGLGGEVSGVMSKPNVDPQPWFQDGPK 29 1 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 S(0.057)NS(0.911)GLGGEVS(0.014)GVMS(0.018)KPNVDPQPWFQDGPK 74.874 3.5265e-05 7134100.0 58242.0 53943.0 59132.0 71994.0 76647.0 41749.0 51649.0 59669.0 44862.0 55987.0 True False 55005.14280119885 58080.25464591701 55327.511498053645 62188.293003422725 67017.91862712608 47499.54579031152 54050.78084055192 59842.62691126528 53835.653549011695 54370.50983830438 1.0116723746895484 1.0682308262079068 1.0176014840139507 1.143787196190878 1.2326152325301816 0.8736270072061707 0.9941194408751486 1.1006449468514228 0.9901627501584347 1.0 15.73053673606039 -6.76757144952492 24.99994186831136 0.998151714082026 1.0917411555972232 0.30092380151117404 0.07817259913028432 228.88254306918344 933127.9587963407 0.028974762622453038 0.026202213034235283 1.7077667375353745e-07 6.76757144952492 0.09358944151519721 SNS(ph)GRELTDEEILASVMIK ddPTM_A459_Selumetinib_30min_R1 2 SNSGRELTDEEILASVMIK 19 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 S(0.21)NS(0.79)GRELTDEEILASVMIK;S(0.236)NS(0.764)GRELTDEEILASVMIK 139.45 7.2783e-05 21946000.0 4310.22 5060.8 6955.2 6983.4 6430.0 5511.5 4985.0 4477.2699999999995 2726.69 3608.98 True False 4410.639739771847 4468.279183297907 6010.722042178878 5763.880284653361 5848.4076353087 5456.059314041608 4608.977436553473 4358.518255377407 4626.993780441825 4072.227737442122 1.083102425539268 1.0972567035517902 1.4760279703694512 1.4154120683520053 1.4361690976993948 1.3398217550251028 1.1318073874346966 1.07030316976209 1.1362315859446914 1.0 11.99160253038096 -7.359855995870416 4.039781003016258 1.081663342338856 1.3166959527796913 0.42660464014838173 0.1276586111749094 0.26523517761437904 7.70356448864055 0.06326586113140813 0.041416196115860546 4.3666059692834786e-08 7.359855995870416 0.23503261044083534 SNS(ph)IQQMEQLNR ddPTM_A459_Selumetinib_30min_R2 2 SNSIQQMEQLNR 12 0 A0A2R8Y6F3;Q9P2P5;A0A2R8YE75 A0A2R8Y6F3 HECW2 E3 ubiquitin-protein ligase HECW2 1 S(0.25)NS(0.75)IQQMEQLNR;S(0.184)NS(0.816)IQQMEQLNR 165.89 2.539e-05 0.0 26152.0 27770.0 24674.0 22438.2 26818.0 22554.2 19223.0 21109.3 18168.5 20273.8 True False 24698.57653475074 29899.869705376317 23086.50170301995 19382.078451946007 23448.88308403809 25660.836323357296 20116.90758965188 21170.72456816726 21802.70767030492 19688.442716341564 1.2544708025206446 1.518650821507543 1.1725915571706425 0.9844393856431686 1.19099734914917 1.303345149896421 1.021762253088442 1.0752869017210482 1.1073860936806597 1.0 14.265061383411505 -1.5228787852086763 0.24812750694985752 1.0301263148488737 3.275997387985379 0.38193443304359365 0.1229584227389974 53.824114572457596 0.7296135675423755 0.1682089540011129 50.32462982894337 0.0299999972418482 1.5228787852086763 2.2458710731365055 SNS(ph)ISVGEFYR ddPTM_A459_Selumetinib_30min_R2 1 SNSISVGEFYR 11 0 E9PC85;Q5S007 E9PC85 LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 1 S(0.031)NS(0.876)IS(0.093)VGEFYR 83.869 0.046105 0.0 8505.4 8798.8 8662.4 9990.3 6976.2 6367.5 5665.7 5993.3 7942.3 7467.6 True False 8032.703917813888 9473.639667398813 8105.070614908006 8629.603905771237 6099.787387980708 7244.56532659006 5929.166276371563 6010.739510755771 9530.981926403543 7251.9909848450825 1.1076549784190726 1.3063501715868706 1.1176338514272364 1.1899634078151826 0.8411189976280717 0.9989760524702057 0.8175915122842947 0.8288399038714709 1.3142572772526888 1.0 12.8241614162903 -6.243573211023499 23.97901222793447 0.9523879400764791 1.1849137068595432 0.3438027905828147 0.14369048948731558 518.9554624780161 696513.1333187419 0.04166736706292509 0.053658372266045015 5.707248583409703e-07 6.243573211023499 0.23252576678306414 SNS(ph)KDIQNLSVGLPR ddPTM_A459_Selumetinib_30min_R1 1 SNSKDIQNLSVGLPR 15 1 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1;A0A1B0GTX4 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 S(0.013)NS(0.979)KDIQNLS(0.008)VGLPR 127.88 0.0048336 11015000.0 808.41 783.36 906.75 986.69 806.21 789.34 814.19 811.19 482.46 625.16 True False 827.2443801079665 691.6438470258165 783.6183304212245 814.3831139652061 733.288447847936 781.3999562633771 752.7749927918707 789.6746060835279 818.6993825157836 705.405375574073 1.172721967754695 0.9804913188575334 1.110876607345812 1.1544895207276311 1.0395277286498863 1.10773178560974 1.0671523337616293 1.1194621325941483 1.1606083691232287 1.0 9.462308759704621 -7.775798882087467 24.86359211940543 1.1050264229591065 1.0881573321429634 0.0 0.06416913111176069 1509.266174362642 2613274.4445610857 0.0331076911797951 0.016036362817158832 1.675718706803917e-08 7.775798882087467 -0.016869090816143073 SNS(ph)LDKHQQSSTLGNSVVR ddPTM_A459_Selumetinib_30min_R1 1 SNSLDKHQQSSTLGNSVVR 19 1 Q6ZSL5;A0A088AWN3;A0A0A0MSY4;Q9BZ29-3;Q9BZ29-5;Q9BZ29;Q9BZ29-4;X6RGR3 Q6ZSL5 DOCK9 Dedicator of cytokinesis protein 9 1 S(0.284)NS(0.716)LDKHQQSSTLGNSVVR 50.944 0.04518 5304600.0 322.28 381.23 653.19 620.46 461.12 649.03 517.45 471.7 297.2 269.69 True False 329.7884969522836 336.5954143709814 564.4903857158421 512.1083084766767 419.41177741734833 642.5013474720904 478.4183298986149 459.18898370246177 504.3266933708304 304.30733850305813 1.0837349456459768 1.1061035071541623 1.855000896438024 1.6828654576515587 1.3782506182089114 2.1113567311017496 1.5721550858813977 1.508964542101725 1.6572938919307796 1.0 8.249385315261511 -5.243167313565481 23.039812883965865 1.6268304820114061 1.0949187490655605 0.340369991345955 0.27617671449602993 297.05849878643505 374565.0952533987 0.06637601679145921 0.17459685305055098 5.712585148043059e-06 5.243167313565481 -0.5319117329458456 SNS(ph)LDKHQQSSTLGNSVVR ddPTM_A459_Selumetinib_30min_R2 1 SNSLDKHQQSSTLGNSVVR 19 1 Q6ZSL5;A0A088AWN3;A0A0A0MSY4;Q9BZ29-3;Q9BZ29-5;Q9BZ29;Q9BZ29-4;X6RGR3 Q6ZSL5 DOCK9 Dedicator of cytokinesis protein 9 1 S(0.263)NS(0.736)LDKHQQSSTLGNSVVR 55.18899999999999 0.032014 4033000.0 8433.4 5792.5 7220.3 7448.6 7716.2 7799.6 9008.0 6085.1 4715.1 8418.4 True False 7964.705389575049 6236.7661241768965 6755.753758868237 6434.087830448299 6746.82197229677 8873.924102280618 9426.889849013374 6102.806633557468 5658.251750901542 8175.338918370004 0.9742354988706754 0.7628755439316246 0.8263576380531509 0.7870117550712045 0.8252651100661584 1.0854503025361912 1.15308856833215 0.7464897412197125 0.6921121934391538 1.0 12.997062825146374 -6.624610927338049 22.880140205442736 0.9356564825363105 0.8279184324370389 0.11247921291908991 0.14009921116662546 15.621250416841562 3478.208196514337 0.050096209619681524 0.0500961722762009 2.3734991070302065e-07 6.624610927338049 -0.10773805009927162 SNS(ph)LNNGQPK ddPTM_A459_Selumetinib_30min_R2 2 SNSLNNGQPK 10 0 O60333-3 O60333-3 KIF1B Kinesin-like protein KIF1B 1 S(0.054)NS(0.946)LNNGQPK;S(0.044)NS(0.956)LNNGQPK 122.52 0.0044393 78329000.0 144719.0 147103.0 126393.0 177134.0 148628.0 116863.0 155983.0 151143.0 114284.0 146229.0 True False 136676.09733605795 158385.3270893038 118261.01198629315 153008.04362680658 129956.02188882134 132959.8174733089 163236.51857445083 151582.80110692955 137143.99336175932 142006.98882143042 0.962460358256903 1.115334733901503 0.8327830409459838 1.077468404172767 0.9151382123328957 0.9362906613033105 1.1494963728842664 1.067431978981967 0.9657552385271251 1.0 17.115602407616812 -7.225230888512088 24.99375961380564 1.0512903503167736 0.975415939493455 0.14137241113967758 0.08690230267572709 1118.7534096885531 772246.5514503457 0.03224648033970017 0.024977310639412567 5.953455496058378e-08 7.225230888512088 -0.0758744108233187 SNS(ph)LPHSAVSNAGSK ddPTM_A459_Selumetinib_30min_R1 3 SNSLPHSAVSNAGSK 15 0 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 S(0.008)NS(0.867)LPHS(0.125)AVSNAGSK;S(0.024)NS(0.956)LPHS(0.013)AVS(0.007)NAGSK;S(0.247)NS(0.753)LPHSAVSNAGSK 212.35 7.718800000000002e-07 55977000.0 10625.49 9885.95 10869.43 12159.779999999999 12270.02 9757.53 11810.960000000001 9616.32 3668.61 7724.280000000001 True False 10873.043243395554 8728.498378146529 9393.421107505235 10036.302690340264 11160.198857447976 9659.37810732839 10920.049778141547 9361.263955390417 6225.363225326923 8715.766578858695 1.2475142771457 1.0014607779100828 1.077750421895222 1.1515111837304952 1.280460961921421 1.108264892127625 1.2529075531496734 1.0740608838811112 0.7142645651419129 1.0 13.089411844122749 -8.07397859129157 6.098382831117705 0.8623480336252386 1.1538849690479807 0.5715934177963959 0.1033358026493162 0.16464938927765754 10.585712089971453 0.06932123682252553 0.02584848528016558 8.43376331290313e-09 8.07397859129157 0.29153693542274206 SNS(ph)LPHSAVSNAGSK ddPTM_A459_Selumetinib_30min_R2 1 SNSLPHSAVSNAGSK 15 0 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 S(0.357)NS(0.643)LPHSAVSNAGSK 111.93 0.0020731 17765000.0 62187.0 48926.0 69235.0 84229.0 77901.0 59501.0 55562.0 59627.0 48064.0 60606.0 True False 58730.89549428511 52678.46687811458 64780.49547736838 72756.86489687067 68114.37993622384 67696.72265370021 58145.743094014346 59800.50469821875 57678.143020366886 58856.14730670109 0.9978718992297732 0.8950376347878424 1.1006581035587555 1.2361812355425261 1.1573027296754208 1.150206490766897 0.98792982134925 1.0160451785366886 0.9799850255200092 1.0 15.84490548683909 -10.217474393578804 8.247993242125782 1.0000053987678543 1.0619710456211433 0.029325564999746256 0.09747202798231819 0.0 0.0 0.10627499704114428 0.02577547283310837 6.060739341768614e-11 10.217474393578804 0.06196564685328898 SNS(ph)MLELAPK ddPTM_A459_Selumetinib_30min_R1 1 SNSMLELAPK 10 0 A6PVU7;Q9P2M7-2;Q9P2M7;A2A3M4 A6PVU7 CGN Cingulin 1 S(0.007)NS(0.993)MLELAPK 125.61 0.0035964 5637700.0 3581.4 4805.7 4720.4 4799.9 4187.9 4083.7 3968.6 3971.9 1905.0 3188.7 True False 3664.839651808701 4243.046409890683 4079.3956073011855 3961.6875702820494 3809.1051844337994 4042.621685702935 3669.2453068618106 3866.552309450515 3232.645864304955 3598.00070556825 1.0185766906985347 1.1792789265783532 1.1337951104311712 1.1010802649790923 1.0586727174730246 1.123574456071282 1.0198011637916866 1.07463911929385 0.8984561507456423 1.0 11.812979754164132 -7.786188530895359 1.2413363750619046 0.9605091013714636 1.1064802738649142 0.49061609370599224 0.05465398096215685 0.38033849960286786 1.0643457763723574 0.04448451159106402 0.017066450459659877 1.6361061197855934e-08 7.786188530895359 0.1459711724934506 SNS(ph)MLELAPK ddPTM_A459_Selumetinib_30min_R2 1 SNSMLELAPK 10 0 A6PVU7;Q9P2M7-2;Q9P2M7;A2A3M4 A6PVU7 CGN Cingulin 1 S(0.035)NS(0.965)MLELAPK 114.56 0.006941199999999999 5747900.0 43312.0 42258.0 49998.0 51057.0 41870.0 34550.0 36971.0 35198.0 32279.0 46074.0 True False 40904.89243167343 45499.05271911389 46781.18311370643 44102.94852176234 36609.91627745078 39308.94888632694 38690.22475664668 35300.42035265743 38735.70195061631 44743.72390537153 0.91420402374606 1.0168812237296074 1.0455362010690912 0.9856789885221809 0.8182134405012212 0.8785354783938282 0.8647073014859606 0.7889468571573135 0.865723694177499 1.0 15.449397712751086 -6.214908364559813 7.8910693759810275 0.859079987384913 0.996838649298455 0.4850316564468433 0.06051142413290103 0.23269033416988583 35.995396534081465 0.017285964255664386 0.022255894438664457 6.096655221186975e-07 6.214908364559813 0.13775866191354202 SNS(ph)PGTASSGSSR ddPTM_A459_Selumetinib_30min_R2 1 SNSPGTASSGSSR 13 0 H0YAP0;Q96GY0 H0YAP0 ZC2HC1A Zinc finger C2HC domain-containing protein 1A 1 S(0.037)NS(0.96)PGT(0.003)ASSGSSR 161.94 0.0003635 4909000.0 4093.8 4954.3 5579.6 4764.7 5057.6 5432.3 10239.0 31996.0 7195.5 17089.0 True False 3866.2829847798475 5334.278879414691 5220.614610609146 4115.739640434046 4422.219072482328 6180.550015490414 10715.133788193603 32089.103062777067 8634.801059068117 16595.59616744572 0.2329704185236823 0.32142737299661023 0.3145783108925015 0.24800191562310786 0.2664694312794287 0.37242109009704116 0.645661275442014 1.9335914623979429 0.520306771262989 1.0 14.018512836164742 -7.53142698688816 24.918906740901768 1.1940949710174373 0.3098401584628692 0.582580238256167 0.32468530740972357 119.02982264808001 346977.1728121035 0.14052414238569916 0.08129504450895254 2.941528178670304e-08 7.53142698688816 -0.8842548125545682 SNS(ph)PLPVPPSK ddPTM_A459_Selumetinib_30min_R1 6 SNSPLPVPPSK 11 0 Q13247-3;Q13247 Q13247-3 SRSF6 Serine/arginine-rich splicing factor 6 1 S(0.001)NS(0.999)PLPVPPSK;S(0.039)NS(0.96)PLPVPPSK;S(0.004)NS(0.996)PLPVPPSK;S(0.04)NS(0.914)PLPVPPS(0.046)K;S(0.097)NS(0.903)PLPVPPSK;S(0.025)NS(0.975)PLPVPPSK 180.85 4.5447e-05 1326976000.0 92758.5 100460.4 94218.29999999999 96025.2 90649.9 79457.6 92217.9 88098.4 50307.6 80538.5 True False 94919.5925733782 88698.44966522699 81423.97236407617 79256.20143624826 82450.63255053975 78658.32868572845 85261.82955794282 85761.74424806645 85368.32287827173 90876.4009864236 1.0444911059754516 0.9760339175236266 0.8959858828062571 0.8721318249397736 0.9072832072526441 0.8655528589592754 0.9382174979693622 0.9437185376749102 0.9393893458767724 1.0 16.471618079908623 -10.752535235456364 14.762034708897124 1.0000007512295979 0.9278628312958918 0.14221011089487468 0.04984197987797281 0.0 0.0 0.051978450432667286 0.012606625964107014 1.7679287751926667e-11 10.752535235456364 -0.07213791993370611 SNS(ph)PLPVPPSK ddPTM_A459_Selumetinib_30min_R2 7 SNSPLPVPPSK 11 0 Q13247-3;Q13247 Q13247-3 SRSF6 Serine/arginine-rich splicing factor 6 1 S(0.045)NS(0.944)PLPVPPS(0.011)K;S(0.016)NS(0.983)PLPVPPS(0.001)K;S(0.006)NS(0.879)PLPVPPS(0.115)K;S(0.004)NS(0.996)PLPVPPSK;S(0.004)NS(0.996)PLPVPPSK;S(0.337)NS(0.663)PLPVPPSK;S(0.287)NS(0.713)PLPVPPSK 162.88 0.00055892 2009829500.0 6878993.0 6245166.0 6849072.0 7608699.0 7807307.0 5893036.0 6817683.0 6993489.0 6179272.0 6418536.0 True False 6496686.107850818 6724150.150826301 6408410.16422576 6572381.070462118 6826483.296449862 6704748.2173454305 7134718.768482568 7013838.895155569 7415299.063285386 6233216.1883206945 1.0422686958979206 1.078760939404842 1.0281065136539513 1.0544125010098195 1.095178330127677 1.0756482712581437 1.1446288004338816 1.1252359429306404 1.1896425279103242 1.0 22.571545320322507 -6.721508319670408 1.4480476151365296 1.123372658074913 1.0517439690017276 0.22608268816972532 0.04782344082640972 0.503343013460002 2.2006850979603536 0.020383112475127686 0.01909002990446291 1.898854465874433e-07 6.721508319670408 -0.07162868907318543 SNS(ph)QSDSHDEEVSPTPPNPVVK ddPTM_A459_Selumetinib_30min_R2 1 SNSQSDSHDEEVSPTPPNPVVK 22 0 C9J4C2;C9IZL8;C9JR00;C9JSK5;P31321 C9J4C2 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit 1 S(0.359)NS(0.464)QS(0.142)DS(0.035)HDEEVSPTPPNPVVK 108.3 3.6719e-05 7896700.0 24866.0 20199.0 30031.0 34042.0 35009.0 24582.0 27145.0 24768.0 26266.0 33791.0 True False 23484.047266484828 21748.198349978265 28098.83815528054 29405.420874274514 30610.856435568996 27967.94736682168 28407.296286797082 24840.070779436865 31519.93393335878 32815.366030438185 0.715641789419688 0.6627443475658791 0.8562707522206887 0.8960869382654228 0.9328208134925456 0.8522820480161569 0.8656705599580282 0.7569646109202693 0.960523612752702 1.0 15.002083904905687 -5.323302430042449 4.947623029352192 0.8824640357382078 0.6889488975757438 0.6093997477737687 0.06427311439156204 0.12868752655634128 6.428897251440359 0.01652297747280891 0.0365958517518114 4.750043315461761e-06 5.323302430042449 -0.1935151381624639 SNS(ph)QTLSDAPFTTCPEGPAR ddPTM_A459_Selumetinib_30min_R2 2 SNSQTLSDAPFTTCPEGPAR 20 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 S(0.039)NS(0.763)QT(0.198)LSDAPFTTCPEGPAR;S(0.054)NS(0.586)QT(0.06)LS(0.3)DAPFTTCPEGPAR 333.01 4.2760999999999985e-155 13526400.0 44764.0 31244.0 26919.0 41911.0 33787.0 20753.3 37095.0 37993.0 26408.0 20523.9 True False 42276.19608448994 33640.31433470572 25187.060847191133 36202.649499492356 29542.375000387612 23611.87869529982 38819.99100234805 38103.553339920276 31690.337901170282 19931.321679503726 2.121093461050526 1.6878115197598544 1.2636924561351153 1.8163697361184616 1.4822085296414318 1.1846619644687675 1.947687746280689 1.911742429961575 1.5899767416708186 1.0 14.282749760436072 -4.8028307463541315 3.9491944165839157 1.5641100601951003 2.159988329658451 0.2577438894798767 0.2989089700815009 0.326167116113721 9.220063872422404 0.0747622971846024 0.5311322432115443 1.5745963980649068e-05 4.8028307463541315 0.5958782694633507 SNS(ph)REHLGGGSESDNWR ddPTM_A459_Selumetinib_30min_R1 1 SNSREHLGGGSESDNWR 17 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.113)NS(0.887)REHLGGGSESDNWR 70.45100000000002 0.013683 12568000.0 2542.8 2998.3 3338.7 3545.6 3908.0 2646.3 2785.5 2793.2 1231.8 2045.2 True False 2602.0422925725043 2647.2576421281474 2885.322878166355 2926.4275191549873 3554.5220900134373 2619.6806246481565 2575.3874923810854 2719.115262407709 2090.2746328875796 2307.7213419350146 1.12753747399619 1.1471305456266365 1.2502908499979568 1.2681026369939405 1.5402735267131453 1.1351806550662504 1.1159872058996663 1.1782684559859997 0.9057742782475172 1.0 11.17225331329045 -7.875234401212395 1.3032904799124936 0.9641555472981845 1.2509337939126415 0.4366028428803058 0.12063715317839231 0.4613547039425846 1.4147679491836227 0.1116940470931421 0.04048467436435872 1.3328018865215913e-08 7.875234401212395 0.28677824661445694 SNS(ph)REHLGGGSESDNWR ddPTM_A459_Selumetinib_30min_R2 1 SNSREHLGGGSESDNWR 17 1 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.413)NS(0.587)REHLGGGSESDNWR 68.168 0.020451 116730000.0 24039.0 23018.0 23828.0 30634.0 44800.0 20086.0 13781.0 14824.0 10174.0 30781.0 True False 22703.008615741546 24783.4065854646 22294.932421964804 26461.596353402438 39171.823482918444 22852.66417744611 14421.843806533441 14867.135385754693 12209.084285311515 29892.27255135741 0.7594942330575867 0.8290907472118303 0.7458426716690829 0.8852320046239112 1.3104331032583083 0.7645007296846813 0.4824606018747994 0.4973571467412428 0.4084361356044541 1.0 14.867484961207246 -7.00594153726744 24.99545640648574 0.5649342550545354 0.9062688644418403 0.31992154506671844 0.21027827557487558 297.9756618409784 1253557.3158976194 0.07660958448006971 0.06540581716095611 9.864122629916813e-08 7.00594153726744 0.34133460938730487 SNS(ph)SEALLVDR ddPTM_A459_Selumetinib_30min_R2 1 SNSSEALLVDR 11 0 Q96HB5-2;Q96HB5;Q96HB5-5;Q96HB5-3;Q96HB5-4 Q96HB5-2 CCDC120 Coiled-coil domain-containing protein 120 1 S(0.011)NS(0.899)S(0.089)EALLVDR 110.22 0.0089489 3076200.0 10288.0 8933.2 12290.0 13585.0 13039.0 12546.0 10634.0 10222.0 8612.1 9360.2 True False 9716.234146127083 9618.347715234711 11499.274780340244 11734.699564567867 11400.924249861013 14274.097618751302 11128.502070871256 10251.744327656806 10334.760642179217 9089.946705279735 1.0688989122987465 1.0581302649055206 1.2650541475299402 1.2909536155753227 1.2542344437772102 1.5703169756166386 1.2242648314326707 1.1278112688716053 1.136944030285288 1.0 13.15005612052767 -8.244348004973167 1.5986435097228622 1.023022491810992 1.2516170455051931 0.2385360495701574 0.13509260085565777 0.5894836244913938 2.8298810954723934 0.1391036054967571 0.04222846146482843 5.697075763435456e-09 8.244348004973167 0.22859455369420112 SNS(ph)SSEAVLGQEELSAQAK ddPTM_A459_Selumetinib_30min_R1 1 SNSSSEAVLGQEELSAQAK 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.014)NS(0.473)S(0.473)S(0.041)EAVLGQEELSAQAK 293.63 9.883499999999995e-86 19873000.0 2468.0 2735.6 2799.7 2863.0 2772.1 2535.1 2890.2 3268.8 1829.3 2567.1 True False 2525.4995981079664 2415.3146802540623 2419.5161176512847 2363.0307951660457 2521.3640444540065 2509.599195686633 2672.189887086631 3182.100805441186 3104.1884932141993 2896.6122906715123 0.8718804398646283 0.8338412040964335 0.8352916700116522 0.8157911926204773 0.8704527190518434 0.8663911299999492 0.9225224569033179 1.0985594501856821 1.0716617143451275 1.0 11.500150878570409 -7.57432856014864 3.0755315957926856 1.0639379771477566 0.8480362625678443 0.904274872939552 0.03005675062492858 0.06927840940478969 1.3349155613461554 0.016092788471309648 0.008724795985872695 2.664841848395015e-08 7.57432856014864 -0.21590171457991236 SNS(ph)SSEAVLGQEELSAQAK ddPTM_A459_Selumetinib_30min_R2 3 SNSSSEAVLGQEELSAQAK 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.321)NS(0.676)S(0.003)SEAVLGQEELSAQAK;S(0.01)NS(0.635)S(0.177)S(0.177)EAVLGQEELSAQAK;S(0.003)NS(0.497)S(0.497)S(0.004)EAVLGQEELSAQAK 320.27 4.6471999999999974e-135 26338500.0 144664.0 135382.0 146912.0 146978.0 165813.0 126891.0 136363.0 150720.0 131147.0 203689.0 True False 136624.15401587565 145765.36407825883 137459.8418656912 126959.3428488081 144982.0885529722 144369.0834481885 142704.14969815823 151158.57024696062 157380.06455334628 197807.96932242063 0.6906908477139395 0.7369033946284842 0.6949155907952126 0.64183128356102 0.7329436172344304 0.729844626294462 0.7214277068157707 0.7641682524963239 0.7956204448811758 1.0 17.593741025257444 -9.082938384158092 0.5643877649719925 1.0125470036741422 0.6967129017469792 0.926414013037731 0.02496726868505254 0.506180363813439 0.27186078305897976 0.03955979900472678 0.011854302611679421 8.261551526191893e-10 9.082938384158092 -0.315834101927163 SNS(ph)TSSMSSGLPEQDR ddPTM_A459_Selumetinib_30min_R1 1 SNSTSSMSSGLPEQDR 16 0 P42684-2;P42684-6;P42684-3;P42684 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 SNS(0.337)T(0.337)S(0.038)S(0.038)MS(0.124)S(0.124)GLPEQDR 199.61 8.073699999999998e-07 8902200.0 1302.2 1078.8 1323.1 1267.1 1115.7 997.68 1456.8 949.17 560.1 946.41 True False 1332.5387263598845 952.4935944794858 1143.4302872680692 1045.8247714128179 1014.785131992833 987.6442450209623 1346.912403123591 923.9949282613222 950.4487919145434 1067.8909423140615 1.2478228567725707 0.8919390143112217 1.0707369469679349 0.9793366812781206 0.950270380413424 0.9248549696290064 1.2612827300556602 0.8652521448108508 0.8900242096397716 1.0 10.0605486048932 -4.7483339599137455 24.93246352596671 0.9860257885192837 1.2478235070614605 0.3449437456656067 0.10993526671693737 745.343318850445 1417895.2814350957 0.027112893213787743 0.49897323405524296 1.785114345556953e-05 4.7483339599137455 0.2617977185421768 SNS(ph)TTQVSQPR ddPTM_A459_Selumetinib_30min_R1 4 SNSTTQVSQPR 11 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.003)NS(0.988)T(0.009)TQVSQPR;S(0.042)NS(0.777)T(0.18)TQVSQPR;SNS(0.922)T(0.078)T(0.001)QVSQPR;S(0.002)NS(0.771)T(0.226)T(0.001)QVSQPR 182.72 3.486e-05 54139900.0 4932.040000000001 5161.92 5801.02 5650.159999999999 6129.3 4319.459999999999 5386.200000000001 5128.5 2380.3900000000003 4061.55 True False 5046.946935920754 4557.5600066885 5013.273346721956 4663.465622638977 5574.905897215805 4276.010154155885 4979.914597545501 4992.475520284242 4039.3479731931047 4582.889505347232 1.10125869934941 0.9944730287236516 1.0939110229196143 1.0175819463239797 1.2164609010780438 0.9330380209181814 1.086632045510813 1.0893728758808414 0.8813976353739419 1.0 12.16204178704259 -8.251451278441174 24.934337613535963 0.9406988145344315 1.0646760887667615 0.3045772998763664 0.07604720139267888 691.7540263772429 1726908.819261929 0.049408329043660444 0.018180469163415633 5.604652899358568e-09 8.251451278441174 0.12397727423232996 SNS(ph)TTQVSQPR ddPTM_A459_Selumetinib_30min_R2 5 SNSTTQVSQPR 11 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.003)NS(0.988)T(0.009)TQVSQPR;SNS(0.616)T(0.376)T(0.007)QVSQPR;S(0.005)NS(0.497)T(0.497)T(0.001)QVSQPR;S(0.002)NS(0.972)T(0.021)T(0.005)QVSQPR;S(0.017)NS(0.917)T(0.065)T(0.001)QVSQPR 162.67 0.00062825 100750600.0 48995.6 44273.8 56318.2 58392.8 57214.6 36095.4 58863.1 93532.6 52140.0 58640.7 True False 46272.62069692693 47669.45809729528 52694.748326619825 50439.59990680147 50026.790442986254 41067.21370858247 61600.3507850199 93804.76438084456 62569.4569133224 56947.59062416376 0.8125474702224318 0.8370759425433599 0.9253200662059373 0.8857196477316664 0.8784707113097617 0.7211404952952831 1.0817024936412658 1.647212170922675 1.0987200025065362 1.0 15.79734718429053 -7.521924349081139 24.999958011509115 1.2966711635055723 0.8545938277626713 0.544400750675119 0.16628383167063826 23.52865035840371 616379.0117712767 0.07203121712747995 0.04225869042267367 3.006599984719246e-08 7.521924349081139 -0.442077335742901 SNS(ph)VEKPVSSILSR ddPTM_A459_Selumetinib_30min_R1 2 SNSVEKPVSSILSR 14 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5 Q9UI08-4 EVL Ena/VASP-like protein 1 S(0.012)NS(0.988)VEKPVSSILSR;S(0.002)NS(0.782)VEKPVS(0.196)S(0.02)ILSR 165.24 0.0012081 41573000.0 5256.4 6483.0 6306.2 7107.5 6060.0 5502.700000000001 5934.4 5973.9 2905.4 5118.5 True False 5378.863892826058 5723.96734613507 5449.852677477063 5866.308549298876 5511.874069979898 5447.347834051848 5486.7634301871485 5815.452766038029 4930.251597979848 5775.509333412073 0.9313228638916105 0.9910757676420284 0.9436142100834217 1.0157214213751709 0.9543528980367133 0.9431805092129679 0.9500051187599176 1.0069160017446215 0.8536479318729001 1.0 12.49573246588962 -6.494346626919804 24.59640223801026 0.9508723845745632 0.9718729398490955 0.042386580949799635 0.04449856550340278 2018.540951824329 1740106.964050948 0.013040753120208063 0.014752156930019621 3.2037113001526764e-07 6.494346626919804 0.021000555274532262 SNS(ph)VEKPVSSILSR ddPTM_A459_Selumetinib_30min_R2 2 SNSVEKPVSSILSR 14 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5 Q9UI08-4 EVL Ena/VASP-like protein 1 SNS(0.998)VEKPVS(0.002)SILSR;S(0.231)NS(0.769)VEKPVSSILSR 183.76 0.00036761 36023800.0 129718.0 117016.0 142402.0 130857.0 141878.0 73099.0 108086.0 105765.0 91663.0 126329.0 True False 122508.79286229725 125990.75093425692 133240.01035557486 113034.0508590839 124054.01723458701 83167.72372334615 113112.21316834599 106072.75863966174 109998.16127821009 122681.55352783948 0.9985917959092112 1.0269738792121386 1.086063931570115 0.9213614240174557 1.0111872051443829 0.6779154757318372 0.9219985394354989 0.8646186455047719 0.8966153273666263 1.0 16.90455881525056 SNS(ph)WVNTGGPK ddPTM_A459_Selumetinib_30min_R1 4 SNSWVNTGGPK 11 0 Q96N67-2;Q96N67-6;Q96N67;A0A1B0GWE0;A0A0U1RRC1 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SNS(0.94)WVNT(0.06)GGPK;S(0.07)NS(0.766)WVNT(0.165)GGPK;S(0.001)NS(0.663)WVNT(0.336)GGPK;SNS(0.64)WVNT(0.36)GGPK 177.21 6.6025e-05 68473000.0 12393.300000000001 15166.9 17309.2 16663.6 14696.899999999998 13193.099999999999 14328.300000000001 14131.1 8038.299999999999 11743.300000000001 True False 12682.039776836087 13391.152297099477 14958.705712629793 13753.615074512367 13367.56798994844 13060.38939237637 13247.504795219491 13756.297323718163 13640.408005796586 13250.666944428647 0.9570869021176596 1.0106021344631184 1.1289020979369877 1.037956438886662 1.0088222763435273 0.9856401528428513 0.9997613592415825 1.038158862599902 1.0294129392129812 1.0 13.69377735607089 -6.257559249499792 19.422850457626573 1.0104473585611249 1.0387962399928021 0.06399254266246512 0.04190476284886952 43.15957560186197 216029.13126144887 0.013517468317306065 0.01669873537646756 5.526380080474534e-07 6.257559249499792 0.028348881431677242 SNS(ph)WVNTGGPK ddPTM_A459_Selumetinib_30min_R2 1 SNSWVNTGGPK 11 0 Q96N67-2;Q96N67-6;Q96N67;A0A1B0GWE0;A0A0U1RRC1 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SNS(0.894)WVNT(0.106)GGPK 131.66 0.0021596 9994100.0 60357.0 45397.0 60895.0 65242.0 57520.0 39705.0 48248.0 54364.0 39126.0 49042.0 True False 57002.59956821465 48878.80392563809 56977.081997462905 56355.927051272476 50293.82336467565 45174.00334389611 50491.6276015983 54522.1902395553 46952.293271780865 47626.03003358141 1.19687909170724 1.0263043947012451 1.1963433012847808 1.183300959822508 1.0560154463685754 0.9485149888001086 1.060168726345579 1.144798132473174 0.9858536022984598 1.0 15.5394626744288 -6.376918166224167 5.747589113074866 1.0353921241635318 1.1445984331954169 0.428451795206765 0.06696953559057157 0.25904603173932744 11.33244094890899 0.02143408210398994 0.024325207823031225 4.198380863064878e-07 6.376918166224167 0.10920630903188511 SNSFS(ph)DER ddPTM_A459_Selumetinib_30min_R1 2 SNSFSDER 8 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.001)NS(0.237)FS(0.763)DER;SNS(0.005)FS(0.995)DER 180.66 0.00043557 681710000.0 25874.0 30579.0 18387.9 18212.8 24955.0 21413.9 24515.0 23035.0 12085.9 24211.0 True False 26476.8138579601 26998.796464208583 15890.924177504749 15032.27637659802 22697.82465616309 21198.49560826554 22665.813812860277 22424.036971774884 20508.88958078909 27318.717685110823 0.9691821615913702 0.9882893031587422 0.5816863134160055 0.5502555628660005 0.8308524916062879 0.7759696429609172 0.8296807366333135 0.8208305100644008 0.7507266562502966 1.0 14.737602146019723 -9.696434592638242 9.259368647645463 0.9999993804299868 0.7844113145982877 0.1833962249481751 0.1335556893628927 0.0 0.0 0.14016039539999833 0.033993889103678177 2.0117101510385817e-10 9.696434592638242 -0.2155880658316991 SNSFS(ph)DER ddPTM_A459_Selumetinib_30min_R2 2 SNSFSDER 8 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 SNS(0.011)FS(0.989)DER;SNS(0.009)FS(0.991)DER 147.3 0.0017280000000000002 1868630000.0 1443210.0 1149440.0 1333810.0 1427790.0 1382360.0 1312110.0 1484820.0 1386900.0 1240740.0 1060010.0 True False 1363002.1658273775 1237598.351967869 1247994.1167425218 1233322.5389248708 1208695.5783448024 1492841.24235133 1553867.0721150145 1390935.6493863445 1488922.669172149 1029404.7570632632 1.3240682602981333 1.202246583257057 1.2123453949279008 1.198092908025172 1.1741694120328614 1.4501985075435062 1.509481145733155 1.351203829050173 1.4463918676846037 1.0 19.973378923948154 -6.756775737935815 24.99936966820106 1.3832819430770344 1.2191917984899725 0.16458090488013777 0.1364281073445754 160.0723811294087 858064.2883414722 0.0431446097339764 0.04179628527286592 1.750750512146937e-07 6.756775737935815 -0.16409014458706195 SNSGLAT(ph)YSPPMGPVSER ddPTM_A459_Selumetinib_30min_R1 1 SNSGLATYSPPMGPVSER 18 0 H0Y465;P21359-2;P21359-6;P21359;J3KSB5;P21359-4 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 S(0.001)NS(0.375)GLAT(0.615)YS(0.009)PPMGPVSER 222.93 2.7609e-14 25077000.0 3007.5 3620.8 3262.4 3908.4 3406.2 3278.0 2937.8 3048.3 1545.5 2583.8 True False 3077.5688984237086 3196.875052735749 2819.383999080456 3225.8713097544432 3098.109811413454 3245.0262961858634 2716.19938076365 2967.44918172613 2622.6006211460913 2915.4558983432903 1.0556046826750283 1.0965266374128229 0.9670473838011313 1.1064723399134753 1.062650206156079 1.113042491237769 0.9316551083167239 1.0178336717123333 0.8995507778513768 1.0 11.509505784160366 -7.266838368932779 24.98283101057153 0.963746026837924 1.0653058090533696 0.5214075105268023 0.04908643608273207 371.455807868683 1718833.2818993016 0.019324114973496075 0.013434586954913397 5.4095561255040514e-08 7.266838368932779 0.1015597822154456 SNSGLATYS(ph)PPMGPVSER ddPTM_A459_Selumetinib_30min_R1 1 SNSGLATYSPPMGPVSER 18 0 H0Y465;P21359-2;P21359-6;P21359;J3KSB5;P21359-4 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 SNS(0.193)GLAT(0.185)YS(0.622)PPMGPVSER 217.67 3.1746e-14 28534000.0 3919.0 5054.5 4875.2 5261.2 4683.5 4393.7 4291.0 4279.6 1729.8 4011.7 True False 4010.3050749534514 4462.716790226699 4213.174617556719 4342.4301849554995 4259.878251939084 4349.503367160412 3967.326415296079 4166.091105900055 2935.3442604066704 4526.640772267116 0.8859340240831474 0.9858782737008749 0.9307508215295377 0.9593052339297169 0.9410683255533824 0.9608678015291269 0.8764394205085309 0.9203493971564958 0.6484597316381563 1.0 12.144225105576917 -7.7936524177864195 2.2545213048037747 0.8243498647943818 0.9427387170058625 0.17321766026727148 0.08649100222736823 0.4311347343266568 4.317631294707533 0.0552203501398987 0.022805597911853537 1.608227863349199e-08 7.7936524177864195 0.11838885221148077 SNSGLATYS(ph)PPMGPVSER ddPTM_A459_Selumetinib_30min_R2 3 SNSGLATYSPPMGPVSER 18 0 H0Y465;P21359-2;P21359-6;P21359;J3KSB5;P21359-4 H0Y465 NF1 Neurofibromin;Neurofibromin truncated 1 S(0.004)NS(0.023)GLAT(0.081)Y(0.014)S(0.878)PPMGPVSER;S(0.005)NSGLAT(0.027)Y(0.015)S(0.952)PPMGPVSER;SNSGLAT(0.154)Y(0.132)S(0.714)PPMGPVSER 124.81 0.0010017 26476200.0 81318.0 60754.0 91189.0 91765.0 89713.0 74086.0 69182.0 73112.0 59410.0 81408.0 True False 76798.67110174596 65413.63644510021 85321.99901907625 79266.44869654554 78442.45089560396 84290.6740142523 72399.10008153225 73324.7438156569 71293.66005409448 79057.53951661433 0.9714275396289856 0.8274180659436436 1.0792392419592747 1.0026424953421085 0.9922197348314755 1.0661939965452405 0.9157772999793046 0.9274857814193338 0.9017945725355109 1.0 16.27061543485349 -9.992014895686594 8.422833162570251 1.0000032973676594 0.9665756706051559 0.02030243837612533 0.07229715706095087 0.0 0.0 0.07204750682218904 0.017474087099429086 1.0185564524090195e-10 9.992014895686594 -0.03342762676250344 SNSLPHS(ph)AVSNAGSK ddPTM_A459_Selumetinib_30min_R1 2 SNSLPHSAVSNAGSK 15 0 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 SNS(0.016)LPHS(0.899)AVS(0.085)NAGSK;SNS(0.232)LPHS(0.753)AVS(0.015)NAGSK 157.7 0.00015248 31781000.0 7322.5 6621.700000000001 8099.7 8221.0 8046.7 7193.700000000001 7773.400000000001 7225.2 2238.7799999999997 5052.7 True False 7493.1000028952985 5846.428285655189 6999.805228467376 6785.356677282592 7318.877405760267 7121.337909357004 7187.0461795997535 7033.564225242801 3799.046145978289 5701.263262465798 1.3142876688796388 1.0254619049334353 1.227763901826901 1.1901496852379911 1.2837290735097278 1.2490807004546258 1.2606059128887435 1.2336852205279119 0.6663516436768087 1.0 12.477065905793594 -8.246805278480224 24.822495276667873 0.833175833570133 1.2197027976479569 0.688326952211229 0.10493132387432066 330.1047844322299 559929.3823881581 0.06766022541759888 0.025322376530627917 5.6649322663410974e-09 8.246805278480224 0.38652696407782383 SNSLPHS(ph)AVSNAGSK ddPTM_A459_Selumetinib_30min_R2 1 SNSLPHSAVSNAGSK 15 0 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 S(0.009)NS(0.445)LPHS(0.541)AVS(0.006)NAGSK 109.1 0.0038293 22479000.0 45108.0 38111.0 50934.0 59501.0 60723.0 41966.0 41711.0 43614.0 37611.0 52604.0 True False 42601.077941631054 41033.99115382055 47656.96189274613 51396.86115504988 53094.4338694923 47746.435570581656 43650.64414877851 43740.909519313645 45134.25093914403 51085.18583839396 0.8339223444620117 0.8032463909132095 0.9328920138121276 1.0061010900037026 1.0393313246907727 0.9346434741693156 0.8544677567948106 0.8562347146526265 0.8835095771585233 1.0 15.64061736511436 -5.267418618764291 23.176030050921433 0.9361542333626486 0.8185843569490692 0.38955433530839856 0.05994085376235115 188.027726093345 728821.5373759532 0.018013322335158597 0.03927255776428609 5.402333381038419e-06 5.267418618764291 -0.11756987641357941 SNSLS(ph)EQLAINTSPDAVK ddPTM_A459_Selumetinib_30min_R1 1 SNSLSEQLAINTSPDAVK 18 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 S(0.034)NS(0.112)LS(0.605)EQLAINT(0.192)S(0.057)PDAVK 79.514 0.012035 18985000.0 768.74 782.28 782.57 1083.7 790.82 788.08 912.53 793.51 499.33 736.72 True False 786.6501462923494 690.6902939278949 676.3012923493112 894.4521385684396 719.290470630611 780.1526307193883 843.6971274178821 772.4635371162613 847.3265403797338 831.2851882604947 0.9463059818718215 0.8308704445621105 0.8135611002097909 1.0759870994936467 0.8652752157605044 0.9384897526586468 1.01493102407293 0.9292401067949729 1.0192970503333596 1.0 9.699199695777494 -6.283452638350963 0.5057003430437229 0.9961810223615702 0.860880928983225 0.2333645288859192 0.07194534909905757 1.9225249202732801 0.9640184642660029 0.05982730202961282 0.12909223841517214 5.206517849836259e-07 6.283452638350963 -0.13530009337834525 SNSLSEQLAINT(ph)SPDAVK ddPTM_A459_Selumetinib_30min_R1 2 SNSLSEQLAINTSPDAVK 18 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 SNSLS(0.002)EQLAINT(0.499)S(0.499)PDAVK;SNSLSEQLAINT(0.5)S(0.5)PDAVK 303.05 1.7854999999999995e-95 27310000.0 7466.799999999999 7416.799999999999 8525.7 8262.9 6656.299999999999 6659.2 6924.099999999999 6403.299999999999 4106.27 5776.9 True False 7640.761912136368 6548.437608023228 7367.9567683178775 6819.939628843007 6054.238840265215 6592.2144940698345 6401.80956237511 6233.463683150255 6968.040279905247 6518.421386771168 1.1721798053195729 1.0046048298308816 1.130328392587629 1.046256328669355 0.9287891164188941 1.0113207021946182 0.9821104194594237 0.9562842463362032 1.0689766534649876 1.0 12.670306903531227 -6.00987609621398 9.4457914023365 0.9893827951518065 1.0919637284915622 0.47452252634048064 0.05223753641408324 0.16353959555656422 136.14907721932042 0.014168936228430132 0.019579231513129097 9.775160655432756e-07 6.00987609621398 0.10258093333975571 SNSLSEQLAINT(ph)SPDAVK ddPTM_A459_Selumetinib_30min_R2 3 SNSLSEQLAINTSPDAVK 18 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 SNSLSEQLAINT(0.927)S(0.073)PDAVK;SNSLSEQLAINT(0.5)S(0.5)PDAVK;SNSLSEQLAINT(0.977)S(0.023)PDAVK 324.45 4.909499999999997e-127 27001900.0 100254.0 101268.0 109035.0 119470.0 118944.0 96738.0 99443.0 96600.0 84321.0 119238.0 True False 94682.28402856004 109034.9299720578 102019.8068083319 103197.97990275461 104001.19134714836 110062.78139986955 104067.2965425663 96881.09000700919 101187.55612559001 115795.28912247009 0.8176695679598845 0.941618012255557 0.8810359003502409 0.8912105206076906 0.8981469983390449 0.9504944651371993 0.8987178781729216 0.8366583022608421 0.8738486417920655 1.0 16.821217036072284 -4.743765100430047 24.79942684757682 0.9022330039242296 0.8176692803236124 0.26893403873972943 0.04375421509659711 1469.5060804278746 2061796.3905957546 0.010675396585276622 0.3217514374526801 1.8039932141119217e-05 4.743765100430047 -0.08456372360061715 SNSLSEQLAINTS(ph)PDAVK ddPTM_A459_Selumetinib_30min_R1 1 SNSLSEQLAINTSPDAVK 18 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 SNSLSEQLAINT(0.064)S(0.936)PDAVK 372.57 2.6833999999999963e-230 19750000.0 2263.5 2032.1 2561.6 2247.3 2080.4 1573.0 1762.9 1976.5 1271.8 1688.5 True False 2316.2351459956967 1794.1807873023392 2213.7487898616037 1854.8512420456361 1892.2281873244513 1557.1770481697274 1629.9230336810679 1924.0767994231858 2158.15171140317 1905.235422382786 1.2157212273005575 0.9417108070867399 1.161929262837752 0.9735548794940329 0.9931728987895536 0.8173147684931457 0.8554969189280566 1.009889264507184 1.132748051001526 1.0 10.895753561498346 -1.5228787454376025 0.6997639471966042 0.9654236305842816 27.875357057461546 0.27486086157500356 0.10354110934526185 410.34267060784197 2.1802843559505485 0.04298882798000127 17275.765501506776 0.029999999989136522 1.5228787454376025 26.909933426877263 SNSLSEQLAINTS(ph)PDAVK ddPTM_A459_Selumetinib_30min_R2 1 SNSLSEQLAINTSPDAVK 18 0 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 SNSLSEQLAINT(0.008)S(0.992)PDAVK 293.08 5.461499999999998e-81 8890900.0 36699.0 38379.0 40702.0 41927.0 39533.0 30452.0 34693.0 33864.0 34417.0 38125.0 True False 34659.41649773696 41322.54589206476 38083.27763298687 36216.4702718908 34566.51111049588 34646.4865842671 36306.293242875334 33962.53863351301 41301.361691327555 37024.232189353854 0.9361278937663726 1.116094607464861 1.028604116304606 0.9781828853780978 0.9336185807638522 0.9357786653636408 0.9806089443582044 0.9173056840130444 1.1155224362276868 1.0 15.176182196681468 -5.75326676627436 5.147846535056135 0.9726392612598033 1.0367478645648012 0.08377839359695682 0.06604243608797207 0.3243000277929448 24.30811189126995 0.01775164791040117 0.02940279860353035 1.7649533614400897e-06 5.75326676627436 0.0641086033049979 SNSLVS(ph)TFTMEK ddPTM_A459_Selumetinib_30min_R2 2 SNSLVSTFTMEK 12 0 Q9HB21 Q9HB21 PLEKHA1 Pleckstrin homology domain-containing family A member 1 1 SNSLVS(0.971)T(0.028)FTMEK;SNS(0.03)LVS(0.944)T(0.026)FTMEK 195.94 0.00010397 37592000.0 174829.0 125902.0 143237.0 141103.0 151788.0 113272.0 151068.0 133606.0 92779.0 95591.0 True False 165112.70407593827 135558.27856126337 134021.2873646538 121884.52798374822 132719.03443806295 128874.18981916147 158092.96133556293 133994.77134033598 111337.39246185534 92831.03945475483 1.7786368120591063 1.4602688858970871 1.4437120186505592 1.3129717032109054 1.4296838128452631 1.3882661508058822 1.7030183251650033 1.4434263811690276 1.1993552276889063 1.0 16.502319652360278 -12.861138619285517 0.1866905739341539 1.2690027920416529e-09 1.5675510061506392 0.525946633782062 0.14588192815826204 60.03481928124623 1.0202704159939597 23.584829110174503 0.4654684543146141 1.3767699576025334e-13 12.861138619285517 1.5675510048816363 SNSQS(ph)DSHDEEVSPTPPNPVVK ddPTM_A459_Selumetinib_30min_R2 1 SNSQSDSHDEEVSPTPPNPVVK 22 0 C9J4C2;C9IZL8;C9JR00;C9JSK5;P31321 C9J4C2 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit 1 S(0.148)NS(0.148)QS(0.633)DS(0.072)HDEEVSPTPPNPVVK 115.55 2.2208e-05 10271000.0 19407.0 20369.0 23177.0 25483.0 35436.0 25906.0 22504.0 24214.0 19961.0 23520.0 True False 18328.436632376382 21931.236803342097 21685.817053209594 22012.171439373044 30984.212878140585 29474.31634874634 23550.480590830033 24284.45873115651 23953.75775693957 22840.91648770106 0.8024387568793717 0.9601732406469421 0.9494284988470826 0.9637166464500554 1.3565223135781077 1.2904174123055485 1.0310654830120782 1.0631998389483512 1.0487213930245634 1.0 14.47933291929286 -6.023995728653887 24.186604562437367 1.1397591654698631 0.9174532652942566 0.4566944723318159 0.11456703982679951 484.93749762172604 488794.94098925183 0.03634547548683841 0.0472273514967807 9.46246467784514e-07 6.023995728653887 -0.22230590017560647 SNSQSDSHDEEVS(ph)PTPPNPVVK ddPTM_A459_Selumetinib_30min_R2 1 SNSQSDSHDEEVSPTPPNPVVK 22 0 C9J4C2;C9IZL8;C9JR00;C9JSK5;P31321 C9J4C2 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit 1 SNSQSDSHDEEVS(0.999)PT(0.001)PPNPVVK 123.85 2.134e-05 19017000.0 62091.0 49137.0 78957.0 101360.0 89902.0 60702.0 60681.0 70086.0 60471.0 75016.0 True False 58640.230789966656 52905.64989964263 73876.99258188148 87554.59314424708 78607.70702592266 69063.14950210747 63502.78673712039 70289.93865663801 72566.8897009113 72850.0931650249 0.8049437995519222 0.7262262490151827 1.0140960618201322 1.2018460010190044 1.0790337199412392 0.9480173120116814 0.8716912220451062 0.9648572239628102 0.9961125174751381 1.0 16.1526431968445 -5.266700200228454 24.248125657540793 1.0104431414828636 0.7655850118567283 0.5761669252542545 0.08366174823214895 204.01557189600751 940353.9488360734 0.02507487327396878 0.054851564469024464 5.411277423610389e-06 5.266700200228454 -0.2448581296261353 SNSS(ph)SEAVLGQEELSAQAK ddPTM_A459_Selumetinib_30min_R1 1 SNSSSEAVLGQEELSAQAK 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.002)NS(0.078)S(0.913)S(0.007)EAVLGQEELSAQAK 367.05 1.3135999999999988e-217 18270000.0 4808.5 4759.3 4885.3 5208.6 5189.3 4669.2 5317.7 5785.6 3662.8 4159.2 True False 4920.528694287749 4202.078943461455 4221.903093032046 4299.015787531213 4719.928731245324 4622.232087294399 4916.5816076951705 5632.147093722632 6215.504079672539 4693.073834038779 1.0484660732586912 0.8953788267688979 0.8996029558304964 0.9160341259390659 1.0057222405093582 0.9849050432084477 1.0476250281926727 1.2000976956451808 1.3243993807622632 1.0 12.196317442484832 -7.533678162405094 2.2401076660226433 1.1979897964947892 0.9510856222651993 0.5454495452801171 0.08734615472030252 0.21258248123196338 2.1216968986297227 0.04895579190654602 0.02558296318558653 2.9263201487906145e-08 7.533678162405094 -0.24690417422958988 SNSSSEAVLGQEELS(ph)AQAK ddPTM_A459_Selumetinib_30min_R2 1 SNSSSEAVLGQEELSAQAK 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 SNS(0.052)S(0.181)S(0.053)EAVLGQEELS(0.715)AQAK 164.48 2.9466e-07 9296700.0 28361.0 26129.0 24797.0 29958.0 30269.0 20970.0 25326.0 29315.0 23632.0 36189.0 True False 26784.809158078348 28133.01028202297 23201.58801693224 25877.668719567475 26466.33761170665 23858.42715329308 26503.709182516963 29400.30179664048 28359.06033324963 35144.12953968594 0.7621417718663948 0.8005038295301701 0.6601838862087115 0.7363297671193004 0.7530799014902323 0.6788737540462152 0.7541432816706436 0.8365636645927071 0.8069359151782552 1.0 15.100996101811806 -8.719624359146236 0.8056366675997819 0.9989603021260886 0.7317366206398921 0.7681977826940316 0.043313719394249404 0.4262321252091937 0.5716858962274559 0.043561305564431343 0.01546799578678075 1.9071095497131035e-09 8.719624359146236 -0.26722368148619646 SNST(ph)SSMSSGLPEQDR ddPTM_A459_Selumetinib_30min_R1 1 SNSTSSMSSGLPEQDR 16 0 P42684-2;P42684-6;P42684-3;P42684 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 SNS(0.09)T(0.763)S(0.003)S(0.003)MS(0.046)S(0.095)GLPEQDR 180.31 3.7922e-09 0.0 592.79 769.58 760.42 658.97 762.53 702.05 1071.7 708.54 362.2 679.27 True False 606.6008536314514 679.477215831964 657.15914068807 543.8932598989064 693.5592961356058 694.9880144103985 990.8608061693803 689.7472175377197 614.6269459586639 766.4609211501062 0.7914308960738948 0.8865125371458997 0.8573941900416471 0.709616426474519 0.9048853985861295 0.9067494444042109 1.2927740721373673 0.8999117874173228 0.8019025223574228 1.0 9.582068426146462 -6.74248185660043 2.9091383309798475 0.998651835782731 0.8214111722669932 0.27818480050750516 0.1270800797802894 0.3571340594925946 6.208417917537269 0.04840717748937637 0.04548629969949556 1.8093314966127625e-07 6.74248185660043 -0.17724066351573775 SNST(ph)SSMSSGLPEQDR ddPTM_A459_Selumetinib_30min_R2 1 SNSTSSMSSGLPEQDR 16 0 P42684-2;P42684-6;P42684-3;P42684 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 S(0.008)NS(0.095)T(0.893)S(0.003)SMSSGLPEQDR 235.79 4.2688e-16 7095500.0 15498.0 15716.0 19422.0 21538.0 20460.0 16994.0 11016.0 14671.0 13111.0 21087.0 True False 14636.683203409551 16921.36666509522 18172.409665074705 18604.487244877644 17889.63188527927 19334.769243827483 11528.265827789883 14713.690181085205 15733.566351948037 20478.163519394224 0.7147458896666984 0.8263127037280235 0.8874042659081313 0.9085036960105295 0.8735955188724107 0.9441651945749985 0.5629540860376383 0.7185063332046515 0.7683094402995303 1.0 14.32179871987458 -7.226604899443635 24.997990199152003 0.7389844481132106 0.861818080085023 0.13174841556735062 0.11534295663442255 962.8800646778581 690984.8851149823 0.04301939952845014 0.03332122728039326 5.9346498540778445e-08 7.226604899443635 0.12283363197181241 SNSVSLVPPGSSHT(ph)LPR ddPTM_A459_Selumetinib_30min_R1 1 SNSVSLVPPGSSHTLPR 17 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 SNSVSLVPPGS(0.003)S(0.002)HT(0.995)LPR 175.19 3.0402e-07 2884000.0 1986.0 1767.9 1764.6 1694.3 2226.7 2006.7 1845.0 1851.6 607.45 1090.7 True False 2032.269935916702 1560.913446125588 1524.9770122539753 1398.4223109499926 2025.2953781558158 1986.5144199378196 1705.8301645819772 1802.489553155562 1030.798283607372 1230.701969317681 1.651309566883542 1.2683114881103026 1.239111539814505 1.1362802252809412 1.6456424289941365 1.6141311783543923 1.3860627569546462 1.46460280237862 0.8375693785383812 1.0 10.265265721184422 -8.259099615462745 24.986719743183066 0.9187846518654965 1.4168631949345378 0.5818260025450809 0.1717641950767303 147.34092278956487 1573523.4805778158 0.13776156529292463 0.046414145710859896 5.506813704362825e-09 8.259099615462745 0.4980785430690413 SNT(ph)LDIMDGR ddPTM_A459_Selumetinib_30min_R1 3 SNTLDIMDGR 10 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 S(0.011)NT(0.989)LDIMDGR;S(0.045)NT(0.955)LDIMDGR;S(0.047)NT(0.953)LDIMDGR 150.26 0.0016761 45330000.0 14598.400000000001 16892.2 17342.6 18006.199999999997 14052.699999999999 15505.6 13753.2 13864.7 7629.799999999999 12563.6 True False 14938.514316458399 14914.453371029278 14987.570176082856 14861.755188235706 12781.635766205687 15349.627741958375 12715.785051235156 13496.963117107318 12947.213341456132 14176.260439827287 1.0537697427235189 1.052072472450357 1.057230165860684 1.0483551181440323 0.9016225273554165 1.0827698748278205 0.8969773873165436 0.9520820511443535 0.9133024464676011 1.0 13.791189393337456 -6.2643019015785075 0.9189333721064645 0.9473821576562145 1.0641825343156213 0.38724361529531837 0.05423118988043136 0.5955623013107051 1.0728101742127663 0.02585058555900115 0.041538236243609666 5.441242711369022e-07 6.2643019015785075 0.11680037665940679 SNT(ph)LDIMDGR ddPTM_A459_Selumetinib_30min_R2 2 SNTLDIMDGR 10 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 SNT(1)LDIMDGR;S(0.002)NT(0.998)LDIMDGR 161.87 0.00097808 42551000.0 101052.0 76581.0 94762.0 108477.0 107825.0 75625.0 84764.0 87323.0 63027.0 80989.0 True False 95435.93438320696 82454.51645327423 88665.11608906457 93702.24546673753 94279.05953226973 86041.65729460123 88705.69395667962 87577.09547289918 75634.16112151848 78650.63713530687 1.2134159093844776 1.0483642530628627 1.1273286437149805 1.1913729993761726 1.1987068759541828 1.0939727944807263 1.1278445691936927 1.1134950543660016 0.9616471509493435 1.0 16.26317083226256 -8.180931430741103 4.1271368673518465 0.9802793529664515 1.1396547951082712 0.6354319802742692 0.04827479709574965 0.14374855204959985 4.394842118012214 0.0380281006207543 0.01274231943060949 6.59277978155146e-09 8.180931430741103 0.15937544214181965 SNT(ph)LPSDVGR ddPTM_A459_Selumetinib_30min_R2 1 SNTLPSDVGR 10 0 F5H4P8;H0YFK8;F5H4N6;Q9Y3R0-3;Q9Y3R0-2;Q9Y3R0 F5H4P8 GRIP1 Glutamate receptor-interacting protein 1 1 S(0.004)NT(0.982)LPS(0.014)DVGR 108.23 0.025269 14744000.0 151630.0 147410.0 159080.0 154310.0 151770.0 104280.0 128980.0 119940.0 101880.0 131910.0 True False 143203.01162298318 158715.87300214323 148844.96599320788 133292.71180040267 132703.29575898492 118643.62344041029 134977.82556902134 120289.00554286403 122258.84676504221 128101.41555666004 1.1178878156864989 1.2389860979478577 1.1619306886376508 1.0405248936647893 1.0359237263876249 0.9261694956675439 1.053679422530033 0.9390138666317819 0.9543910676847 1.0 16.966926892390298 -5.910120136681874 1.8392660415697955 0.9799689051467538 1.1867828848216744 0.7675653005837313 0.046330265884550005 0.15120019478347102 1.0398460531656355 0.01444513557674773 0.025493482581851207 1.2299284948628997e-06 5.910120136681874 0.20681397967492055 SNT(ph)PESIAETPPAR ddPTM_A459_Selumetinib_30min_R1 1 SNTPESIAETPPAR 14 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.013)NT(0.809)PES(0.021)IAET(0.158)PPAR 136.26 0.0013952 15501000.0 2298.7 2978.3 2646.6 3067.3 2699.0 2685.6 2406.8 2324.1 1350.2 2354.6 True False 2352.255237508422 2629.5992514258955 2287.206256733183 2531.6536353520128 2454.875926547152 2658.5853023296995 2225.253138274204 2262.457318259259 2291.1907852937256 2656.8358457462296 0.885359643605584 0.9897484843243358 0.860876015503612 0.9528829714509304 0.9239847958531466 1.0006584737202604 0.8375576315100468 0.8515608225783325 0.8623757425443028 1.0 11.375493377434474 -7.279079783048565 24.988706117560966 0.8755036213840802 0.9349101607141833 0.1267850651603465 0.05778721835711255 1357.0989220405227 1922404.8163957566 0.022753533864329042 0.015375183570092628 5.2592064207644515e-08 7.279079783048565 0.05940653933010309 SNT(ph)PESIAETPPAR ddPTM_A459_Selumetinib_30min_R2 1 SNTPESIAETPPAR 14 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.422)NT(0.572)PES(0.003)IAET(0.003)PPAR 161.94 0.00065331 7061000.0 32577.0 21045.0 26953.0 26000.0 25903.0 15294.0 21371.0 22187.0 16946.0 22589.0 True False 30766.500756063568 22659.083829659525 25218.87332420753 22458.75514749831 22648.833564241893 17400.60967489099 22364.793845833137 22251.560496744423 20335.67351080094 21936.796876729553 1.4025065249476107 1.032925816699163 1.1496151177367004 1.0237937322254393 1.0324585531567585 0.7932156081250619 1.0195104586831272 1.0143486590947455 0.9270119801479734 1.0 14.421065264113679 -1.522878763147873 0.6894046839591721 0.9664549468973781 47.73448654260459 0.6853404201218365 0.08322819595101752 158.30148073231214 0.8768389259164143 0.033171594595963166 11390.32511795506 0.029999998765754397 1.522878763147873 46.768031595707214 SNT(ph)PILVDGK ddPTM_A459_Selumetinib_30min_R1 3 SNTPILVDGK 10 0 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41 P06744-2 GPI Glucose-6-phosphate isomerase 1 S(0.003)NT(0.997)PILVDGK;S(0.086)NT(0.914)PILVDGK;S(0.002)NT(0.998)PILVDGK 138.31 0.0038616 52771100.0 21546.3 27834.1 16933.2 17375.300000000003 16104.7 18683.1 21258.3 20093.0 12098.2 20351.5 True False 22048.2868681984 24575.270632277978 14633.76444740962 14341.030029775964 14648.032728515722 18495.16497689753 19654.76931584449 19560.068368737684 20529.761782432644 22963.813265397243 0.960131778349792 1.0701737707172938 0.6372532417976217 0.6245056020981316 0.6378745794187388 0.8054047802577613 0.8559018090197177 0.8517778882225779 0.8940049087303666 1.0 14.48707460877063 -8.335629017096199 1.0527040876492957 0.993323925251073 0.7865422591299556 0.18094862900411435 0.13590859671781574 0.9649472063945794 2.261134931084708 0.1455619008253145 0.04876639780922154 4.61711809480038e-09 8.335629017096199 -0.20678166612111748 SNT(ph)PILVDGK ddPTM_A459_Selumetinib_30min_R2 3 SNTPILVDGK 10 0 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41 P06744-2 GPI Glucose-6-phosphate isomerase 1 S(0.333)NT(0.667)PILVDGK;S(0.022)NT(0.978)PILVDGK;S(0.006)NT(0.994)PILVDGK 156.52 0.0011867000000000002 109996000.0 568480.0 476530.0 487440.0 516630.0 508520.0 400740.0 514190.0 524180.0 409080.0 420600.0 True False 536886.1574057474 513078.3187145482 456078.6410845451 446264.1027635397 444635.17137351964 455938.2974444761 538100.8538481563 525705.2770173291 490907.4306502086 408456.1851499604 1.3144277817916634 1.2561404071434905 1.1165913448393507 1.092562970003009 1.0885749501143593 1.1162477495036172 1.3174016538655136 1.287054269540127 1.2018606854245018 1.0 18.639821804075638 -7.228528392107612 24.931027397767327 1.2255004338782982 1.1594320636778526 0.008579413827191185 0.10498218851685774 1755.256374332952 1329659.357002431 0.041410419388347434 0.03207324539239951 5.9084233785029434e-08 7.228528392107612 -0.06606837020044565 SNT(ph)PILVDGKDVMPEVNK ddPTM_A459_Selumetinib_30min_R1 1 SNTPILVDGKDVMPEVNK 18 1 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90;K7EPY4;K7ERC6;K7EP41 P06744-2 GPI Glucose-6-phosphate isomerase 1 S(0.068)NT(0.932)PILVDGKDVMPEVNK 80.002 0.016096 56360000.0 5118.5 4526.7 7338.1 7423.9 5371.4 5264.4 4445.2 5452.2 3657.2 4043.8 True False 5237.751091132748 3996.711859594265 6341.626325298031 6127.455228862457 4885.557818397694 5211.444915692759 4109.894985148947 5307.589944758457 6206.001288680358 4562.8611199475945 1.1479093826096782 0.8759223115780846 1.3898354910637443 1.3428975960006497 1.0707224458442 1.142144101846478 0.9007276086448474 1.1632153171515804 1.36011180825763 1.0 12.155723027726376 -5.2403800375385075 24.991918225507735 1.1688811035182365 1.011915896781251 0.13339228728289265 0.16231743876546542 1755.787226704662 2083651.3242456224 0.0426900887437924 0.1126960974720247 5.749366080744166e-06 5.2403800375385075 -0.15696520673698555 SNT(ph)PMGDKDDDDDDDADEK ddPTM_A459_Selumetinib_30min_R2 2 SNTPMGDKDDDDDDDADEK 19 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 S(0.172)NT(0.828)PMGDKDDDDDDDADEK;S(0.222)NT(0.778)PMGDKDDDDDDDADEK 92.679 0.0030424 43310000.0 212320.0 154628.0 176285.0 160202.0 156088.0 136214.0 182535.0 184650.0 125645.0 160182.0 True False 200520.10438430216 166487.47039261524 164943.01502459572 138382.21123613554 136478.82999557533 154976.24207242084 191023.23918624083 185187.30092954676 150777.5108146224 155557.12945718228 1.2890447714226825 1.0702657664973279 1.0603372253021481 0.8895909285483813 0.8773550300897117 0.9962657617379 1.2279941128562721 1.190477746508689 0.9692741910368339 1.0 17.24708499207872 -4.706369429360826 2.5512350358072533 1.0298065118912327 1.3781932853558478 0.3487027329986955 0.10707031230658423 0.927329840407761 6.40487065668523 0.031653557343882435 0.7646931127274589 1.966213033688878e-05 4.706369429360826 0.3483867734646151 SNTACDGDKES(ph)EVEDVETDSGNSPEDLRK ddPTM_A459_Selumetinib_30min_R1 2 SNTACDGDKESEVEDVETDSGNSPEDLRK 29 2 Q7Z3K6-4;Q7Z3K6-3;Q7Z3K6;Q7Z3K6-2 Q7Z3K6-4 MIER3 Mesoderm induction early response protein 3 1 SNT(0.001)ACDGDKES(0.997)EVEDVET(0.002)DSGNSPEDLRK;SNT(0.003)ACDGDKES(0.992)EVEDVET(0.004)DSGNSPEDLRK 95.223 7.413199999999999e-08 39376000.0 4558.9 4964.4 6484.5 5958.7 3788.5 5227.7 4940.700000000001 4904.0 3571.8 4719.6 True False 4665.113499924801 4383.1657401130515 5603.940516808859 4918.124903652087 3445.8308439140023 5175.114084371823 4568.019021219611 4773.929989563014 6061.083726049568 5325.406632797034 0.8760107577878178 0.8230668646256794 1.052302838678355 0.9235210083983704 0.6470549727963529 0.971778202344283 0.8577784451401368 0.8964442189564084 1.138144773531808 1.0 12.378675974267573 -8.194487870475927 7.06687405091883 1.0681998134991397 0.8800660138013351 0.34456645216228976 0.10381113155155952 0.26456402972201837 23.919685331339444 0.07206160809548767 0.02669056747705839 6.390165843602191e-09 8.194487870475927 -0.18813379969780464 SNTACDGDKES(ph)EVEDVETDSGNSPEDLRK ddPTM_A459_Selumetinib_30min_R2 2 SNTACDGDKESEVEDVETDSGNSPEDLRK 29 2 Q7Z3K6-4;Q7Z3K6-3;Q7Z3K6;Q7Z3K6-2 Q7Z3K6-4 MIER3 Mesoderm induction early response protein 3 1 S(0.035)NT(0.17)ACDGDKES(0.793)EVEDVET(0.002)DSGNSPEDLRK;S(0.03)NT(0.137)ACDGDKES(0.833)EVEDVETDSGNSPEDLRK 86.084 1.6175e-06 23452000.0 53036.0 60556.0 47329.0 51588.0 44307.0 32883.0 42463.0 40198.0 28597.0 49132.0 True False 50088.471439929606 65200.4504817706 44283.90366791891 44561.62540573627 38740.75855039436 37412.334767846245 44437.613638838244 40314.969524862856 34317.199066940586 47713.43149973335 1.04977717731766 1.3665009711601852 0.9281223813920487 0.9339430010600958 0.8119466014640105 0.7841048860226145 0.9313439055224227 0.84493963770114 0.7192356111954004 1.0 15.54210782671054 -5.417149292676101 5.095558818267981 0.8570813737662706 1.2056580656268328 0.6307765485158243 0.10457558379539918 0.12521831303401504 4.859670077007105 0.02649736634258061 0.056568416416001965 3.826931664479134e-06 5.417149292676101 0.34857669186056217 SNTLPS(ph)DVGR ddPTM_A459_Selumetinib_30min_R1 1 SNTLPSDVGR 10 0 F5H4P8;H0YFK8;F5H4N6;Q9Y3R0-3;Q9Y3R0-2;Q9Y3R0 F5H4P8 GRIP1 Glutamate receptor-interacting protein 1 1 SNT(0.174)LPS(0.826)DVGR 96.23 0.021921 7915400.0 4154.0 4845.3 4582.5 4720.1 3701.4 4520.3 4303.6 4609.9 2541.6 3956.0 True False 4250.78011772305 4278.01002348114 3960.2216698707043 3895.8231422505232 3366.609023535245 4474.829886104017 3978.9759871517635 4487.630476934446 4312.909568880564 4463.791134703167 0.9522802455240144 0.9583804202267225 0.8871879419004337 0.872761073420965 0.7542039763827609 1.0024729542820743 0.8913893744305663 1.0053406043230704 0.9661987845601481 1.0 12.124053808249979 -7.581552183817688 1.5248486650014519 0.9915855672124385 0.8953355650198959 0.25998132255932715 0.06433755646470374 0.593461782200701 2.6482116360299597 0.04737974547490365 0.021465433009498706 2.620884100359605e-08 7.581552183817688 -0.09625000219254265 SNTPESIAET(ph)PPAR ddPTM_A459_Selumetinib_30min_R1 2 SNTPESIAETPPAR 14 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 SNTPESIAET(1)PPAR;SNTPESIAET(1)PPAR 185.86 0.00018924 17798100.0 3135.8 3433.5 3131.0 4033.1000000000004 3677.8 2792.1 3253.8 3072.9 1436.3600000000001 2521.3 True False 3208.8580387953666 3031.504223809155 2705.8273973519213 3328.7947956633548 3345.14363936833 2764.014009023963 3008.363246350591 2991.3967098140683 2437.398012416305 2844.933414541734 1.127920260767247 1.0655800266936912 0.951103946236921 1.1700782797405338 1.1758249322356005 0.9715566610086003 1.0574459250868558 1.0514821522794504 0.8567504602946655 1.0 11.474179171417285 -8.13274372721933 6.1133661369221555 0.9299573854498312 1.0715017597137537 0.3594663303013921 0.07671508775673445 0.2557271888202905 11.362073583114702 0.05418190944511126 0.019992265454257238 7.366416540569796e-09 8.13274372721933 0.14154437426392252 SNTPMGDKDDDDDDDADEKMQS(ph)SGIPNGGHIR ddPTM_A459_Selumetinib_30min_R2 1 SNTPMGDKDDDDDDDADEKMQSSGIPNGGHIR 32 2 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 S(0.121)NT(0.277)PMGDKDDDDDDDADEKMQS(0.301)S(0.301)GIPNGGHIR 42.894 0.013578 7186300.0 17729.0 14987.0 14484.0 15847.0 14035.0 12163.0 12929.0 11943.0 5982.9 17848.0 True False 16743.693154810167 16136.454709199672 13552.115208986836 13688.611262400209 12271.797825508043 13838.342845279143 13530.22411832748 11977.752152729909 7179.6471761932635 17332.681865326893 0.9660186049052821 0.9309843009049736 0.7818821873201931 0.7897572556145248 0.7080149466111832 0.7983959408475622 0.7806191923128741 0.6910501355644659 0.4142259825674044 1.0 14.081207277813274 -4.817893765207329 0.6616076251496932 0.7109586703123146 1.150432898457665 0.26266204013248207 0.1365144779375344 4.100989937645612 1.4026220911007403 0.06211013300510599 1.357640054403552 1.5209195234299293e-05 4.817893765207329 0.4394742281453504 SNVS(ph)SPATPTASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVS(0.958)S(0.042)PATPTASSSSSTTPTR 234.51 1.7745999999999996e-25 10763000.0 1988.2 2355.4 2693.3 2672.7 2640.2 2299.3 2522.0 2155.7 1289.9 2204.2 True False 2034.5211916362468 2079.6286730042466 2327.564653237921 2205.9631177926262 2401.394376165169 2276.171129597365 2331.7635095261508 2098.52383329955 2188.8660894314753 2487.13054072617 0.8180194639249718 0.836155818502818 0.9358433806045178 0.8869510794349175 0.965528080188357 0.9151795984672317 0.9375316137790434 0.8437529912229063 0.880076881204792 1.0 11.280266516187872 -5.185775669409317 5.232328231287677 0.9157880468759912 0.8236079341377542 0.43717548698360964 0.042245432660137555 0.20888552725360876 10.273955910937062 0.01077273871285571 0.02995140060144136 6.519650733167749e-06 5.185775669409317 -0.09218011273823701 SNVSDAVAQS(ph)TR ddPTM_A459_Selumetinib_30min_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 1 SNVS(0.005)DAVAQS(0.592)T(0.403)R 87.647 0.028232 5355000.0 1540.5 1992.3 2437.4 2201.9 2212.0 1491.9 1817.5 1614.4 985.59 1389.9 True False 1576.3906527088013 1759.0405898048589 2106.4144676798373 1817.3794997820883 2011.92499056032 1476.8928405368179 1680.4045117223543 1571.5808676897484 1672.474245354499 1568.307203772482 1.0051542509763873 1.1216173627039254 1.3431134299536254 1.1588160122012294 1.2828640879291624 0.9417114433857273 1.0714766263141737 1.0020873869031475 1.0664200491660363 1.0 10.614992470357935 -6.765225827605457 24.999811220732852 1.0199156590792609 1.1865690134257034 0.45193178934216627 0.09128570138870844 95.8330006235418 632727.3597969275 0.03236052712073234 0.02962144807623097 1.7170153288612466e-07 6.765225827605457 0.16665335434644257 SNVSDAVAQS(ph)TR ddPTM_A459_Selumetinib_30min_R2 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 1 SNVSDAVAQS(0.909)T(0.091)R 108.66 0.0079681 4670700.0 12760.0 15860.0 15310.0 12733.0 20317.0 11456.0 8801.7 13617.0 12079.0 16709.0 True False 12050.85028232713 17076.411002062247 14324.971268267627 10998.743434349846 17764.59682371549 13033.960012786143 9210.99649023768 13656.623215584299 14495.137515458788 16226.567754804291 0.7426616931210956 1.0523735678487114 0.8828096911638231 0.6778231601746701 1.0947846206389409 0.8032481181318893 0.5676490943385442 0.8416211870523824 0.8932965821541115 1.0 13.986070252708513 -6.959939039749476 24.999936171791976 0.7943004856291733 0.8931198473950832 0.033327751793467586 0.15519332029264685 408.90594666565073 255175.5166247397 0.05416828565066051 0.04777187550546881 1.0966321153838947e-07 6.959939039749476 0.09881936176590989 SNVSS(ph)PATPT(ph)ASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R1 2 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 2 SNVS(0.026)S(0.95)PAT(0.024)PT(0.185)AS(0.109)S(0.142)S(0.177)S(0.136)S(0.105)T(0.081)T(0.062)PT(0.004)R;S(0.002)NVS(0.119)S(0.876)PAT(0.004)PT(0.341)AS(0.183)S(0.045)S(0.182)S(0.134)S(0.033)T(0.025)T(0.055)PT(0.001)R 134.32 0.0010894 0.0 619.69 839.72 876.49 958.0500000000001 989.8399999999999 815.77 675.63 854.62 440.45000000000005 743.88 True False 634.1275712931632 741.4051920247634 757.4674722149422 790.7445523258223 900.3091467704459 807.564094459897 624.6666851471666 831.9527014030066 747.4114808047856 839.364244004801 0.7554855663943867 0.8832937515748202 0.9024299970188028 0.9420755744288047 1.0726084095205946 0.9621140050079116 0.7442140758423749 0.9911700520307701 0.8904495112142405 1.0 9.713153197082807 -4.597608715050402 1.4450128999758336 0.938374199710722 0.6146790867959261 0.3212721555079636 0.08122127961827161 2.416249693508857 3.342115538110288 0.02416037955132145 1.2823592104344428 2.525755369623816e-05 4.597608715050402 -0.3236951129147959 SNVSS(ph)PATPTAS(ph)SSSSTTPTRK ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 2 S(0.034)NVS(0.111)S(0.491)PAT(0.358)PT(0.008)AS(0.188)S(0.165)S(0.145)S(0.099)S(0.057)T(0.166)T(0.148)PT(0.03)RK 63.291 0.022531 6070500.0 1185.7 980.29 1666.4 1484.2 1146.6 1070.6 1073.2 1079.2 484.09 683.55 True False 1213.3245030294227 865.5171910755435 1440.1120328799877 1225.012331884542 1042.890232448672 1059.830736027024 992.2476599617225 1050.5761102643564 821.4653734652937 771.2903008408367 1.573110023173757 1.1221678661484313 1.8671465611716138 1.58826362855733 1.3521371023488113 1.3741009511874185 1.2864775544046192 1.3621020634112098 1.0650534209619358 1.0 9.591130158547902 -7.936476478706397 0.6489224454932959 0.9933204421452443 1.5138669732401029 0.4741073340974088 0.18253014229788994 0.6666291161523245 0.5920915557233978 0.17873546438640714 0.08796358444137047 1.1575067207039836e-08 7.936476478706397 0.5205465310948586 SNVSS(ph)PATPTASSSSS(ph)TTPTR ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 2 SNVS(0.058)S(0.941)PAT(0.001)PT(0.036)AS(0.057)S(0.125)S(0.176)S(0.125)S(0.276)T(0.197)T(0.008)PTR 157.02 4.9831e-06 0.0 8095.3 10283.0 11452.0 9481.4 11497.0 10324.0 8889.4 9159.1 8634.0 9408.0 True False 7645.395634053514 11071.673034943635 10715.190787994834 8190.016963672706 10052.644075515926 11746.037288059018 9302.774714011928 9185.751464629366 10361.041254116339 9136.366595080417 0.8368092013919698 1.2118245168604886 1.1728065721185654 0.8964194768719893 1.100289044983034 1.2856355057363622 1.0182138180642966 1.0054053073544071 1.1340439491225496 1.0 13.157404824405496 -4.743738774857425 24.90337564551122 1.0922713759988294 0.8368083753527181 0.32770611333147126 0.10948973614165214 1366.7945159301044 1922867.0631881761 0.027835691446280553 0.8593685851348182 1.8041025698503867e-05 4.743738774857425 -0.25546300064611127 SNVSS(ph)PATPTASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVS(0.006)S(0.992)PAT(0.002)PTASSSSSTTPTR 133.94 0.00012073 0.0 317.92 359.95 313.78 371.12 270.81 174.04 334.52 185.42 209.04 208.9 True False 325.3269174353668 317.80688666378484 271.1703994701648 306.31085878519826 246.3152833153888 172.28931561567654 309.286887076403 180.50205927095712 354.72561232247097 235.7143498583145 1.380174425659352 1.3482712734918996 1.1504195634808088 1.2995002594000689 1.0449736448521119 0.7309241703750234 1.3121258305330676 0.7657661036735993 1.5048961276039958 1.0 7.880895779670615 -5.746883794926229 1.273509656636397 1.0524374949729363 1.3612131781632941 0.19819622493942723 0.223595652127133 0.7578448077708126 2.4229340372137633 0.07414489913589446 0.19262937177247974 1.7910850342560407e-06 5.746883794926229 0.30877568319035786 SNVSS(ph)PATPTASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVS(0.001)S(0.358)PAT(0.267)PT(0.265)AS(0.077)S(0.013)S(0.003)S(0.006)S(0.006)T(0.002)TPTR 157.88 1.5286e-07 8839700.0 9892.5 11655.0 12992.0 13266.0 15387.0 9302.1 11207.0 12228.0 8908.8 12529.0 True False 9342.714452815142 12548.901023268312 12156.108864620059 11459.14791487356 13453.94749847468 10583.379838943612 11728.147706249205 12263.581455545625 10690.808932669861 12167.255215748579 0.7678571943426059 1.0313666312370726 0.999083905866124 0.9418022151817375 1.1057504145274015 0.8698247592641197 0.9639107176012041 1.007916842220287 0.8786541206789439 1.0 13.570716129914542 -4.752329365045876 24.998604982487237 0.9776005527577131 0.7678567887750639 0.4732160925385376 0.06638560877911828 311.8354473871739 855639.4286029706 0.01584274280380231 0.19096147690336926 1.768767032451734e-05 4.752329365045876 -0.20974376398264916 SNVSSPAT(ph)PTASSSSST(ph)TPTRK ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 2 S(0.006)NVS(0.067)S(0.216)PAT(0.711)PTASS(0.002)S(0.005)S(0.063)S(0.133)T(0.439)T(0.352)PT(0.006)RK 111.38 0.00012953 5341700.0 17679.0 16368.0 16624.0 19280.0 16984.0 16731.0 15017.0 15922.0 12223.0 19697.0 True False 16696.471954644312 17623.372968584797 15554.429938842657 16654.030740144903 14850.318081113546 19035.543381103784 15715.320255620984 15968.330383971004 14667.941539154976 19128.296431047936 0.8728676918423102 0.9213247521603422 0.8131633674181049 0.8706489258036094 0.776353405785231 0.995151003107961 0.8215744832411104 0.8348014911590423 0.7668190208170774 1.0 14.223420772317708 -11.036972916891672 2.9369147411298075 1.0054368677226773 0.8544449955435073 0.3184625770572884 0.06466851255672192 24814894.56177011 26674643.54995301 1075830.1652269324 0.016892184807656585 9.18389866556643e-12 11.036972916891672 -0.15099187217916998 SNVSSPAT(ph)PTASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSS(0.002)PAT(0.869)PT(0.119)AS(0.006)S(0.002)SS(0.001)S(0.001)TTPTR 189.84 3.5221e-16 10167000.0 9716.6 10200.0 10791.0 10815.0 15173.0 8372.2 14186.0 9087.8 7982.3 9925.2 True False 9176.590270631656 10982.3072018307 10096.718808352445 9341.978343084396 13266.832091658955 9525.394554735354 14845.677109025713 9114.243993433725 9578.983044096922 9638.633687233447 0.9520633907673266 1.1394049777383877 1.0475259394623266 0.9692222618085408 1.3764224808367937 0.9882515368699943 1.540226300817832 0.9455950178401026 0.9938112968007558 1.0 13.234612938134275 -4.7574973882902265 24.25531896067263 1.1208944761932609 0.9520630271504268 0.059125854921926235 0.18680295722440146 241.40959637764647 1485097.1724559446 0.04509950462041286 0.3305499217032121 1.7478437733667335e-05 4.7574973882902265 -0.1688314490428341 SNVSSPAT(ph)PTASSSSSTTPTRK ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVS(0.001)S(0.029)PAT(0.886)PT(0.078)AS(0.003)S(0.001)S(0.001)S(0.001)STTPTRK 84.37100000000002 0.00084047 4534500.0 9592.5 10897.0 10339.0 13111.0 11243.0 6722.5 6311.6 10765.0 5736.1 10049.0 True False 9059.387251819986 11732.764860622463 9673.799996252057 11325.259182263475 9830.553826304726 7648.463354220915 6605.101906198138 10796.32436775832 6883.480280025103 9758.859259562409 0.9283244087102669 1.2022680672565171 0.9912838928149308 1.1605105556949393 1.007346613455058 0.7837456357131515 0.6768313519560188 1.1063100799593284 0.7053570603838958 1.0 13.252496801635072 -6.603860236427489 5.199954084222981 0.8512330156465291 1.0755527275504304 0.35170579833158355 0.13994102385215232 0.2197371614126944 10.316486516493443 0.04465518430130731 0.04471992665985242 2.4896584050636935e-07 6.603860236427489 0.22431971190390132 SNVSSPATPT(ph)ASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSS(0.001)PAT(0.082)PT(0.644)AS(0.194)S(0.059)S(0.018)S(0.002)S(0.001)TTPTR 213.01 9.9372e-18 8901500.0 916.03 1270.9 1261.9 1427.4 1341.0 1171.3 1484.2 1326.6 819.1 1110.4 True False 937.3717167159002 1122.1024371746191 1090.5409111205327 1178.1313856164907 1219.7067867727797 1159.5177854553092 1372.2455990637238 1291.4142585958996 1389.9528753029854 1252.9306562119314 0.7481433326485271 0.8955822348278604 0.8703920729481052 0.9403005503739638 0.9734830740436987 0.9254445006246048 1.0952286882440287 1.030714870127225 1.1093613747989233 1.0 10.291090855181768 -5.225557686899935 0.42242366929016756 1.06649428426645 0.6532517178077012 0.7690189036363909 0.04948358162395936 1.7535971447089254 0.32413147520832686 0.0400180353915305 0.35212452172348496 5.948977318423408e-06 5.225557686899935 -0.4132425664587488 SNVSSPATPT(ph)ASSSSSTTPTR ddPTM_A459_Selumetinib_30min_R2 2 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPAT(0.001)PT(0.247)AS(0.116)S(0.116)S(0.056)S(0.056)S(0.056)T(0.177)T(0.177)PT(0.001)R;SNVSSPATPT(0.452)AS(0.237)S(0.038)S(0.022)S(0.022)S(0.012)T(0.046)T(0.17)PT(0.001)R 154.31 1.1466e-06 22418800.0 31028.5 28447.1 35826.0 41856.0 45056.0 32852.0 32764.0 35960.0 26287.6 41980.0 True False 29304.06018692691 30628.901098156668 33520.99416439949 36155.140594372664 39395.66247424937 37377.064799236265 34287.59092063433 36064.63764650152 31545.854536913204 40767.92832286097 0.7188017981893479 0.7512989341913958 0.8222393323234505 0.8868525353567783 0.9663395736534867 0.9168252186677033 0.84104324971076 0.8846325808093113 0.77379096350166 1.0 15.315147025748649 -5.412867171328424 2.074482125184765 0.8924418745519657 0.7252460582231895 0.5448716165801162 0.05892491709106545 0.27155155665367303 2.217839676681084 0.017154607945486042 0.05094067974279651 3.864851652038827e-06 5.412867171328424 -0.16719581632877611 SNVSSPATPT(ph)ASSSSSTTPTRK ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPT(0.626)AS(0.06)S(0.018)S(0.054)S(0.031)S(0.031)T(0.09)T(0.09)PTRK 162.2 2.7254e-09 21003000.0 2192.2 2517.4 2637.3 2910.5 2594.0 2208.1 2198.4 1708.6 1139.4 1821.5 True False 2243.273994721347 2222.661637692491 2279.1691456519393 2402.2358118514762 2359.373158007897 2185.8885187943897 2032.572918058006 1663.282377685026 1933.4785815165699 2055.3072679124934 1.0914543191392327 1.0814254746201397 1.1089189345235055 1.1687964370852182 1.1479418162152626 1.063533688086708 0.988938709939182 0.8092621495832912 0.9407248306382623 1.0 11.005138377233651 -7.3109756101990815 2.5283374106676604 0.9063715895850466 1.1176817387516795 0.7369508319810683 0.05260739161173104 0.13783848957442452 1.7319506879176088 0.02501680775430233 0.016031224907055188 4.886798026305667e-08 7.3109756101990815 0.21131014916663293 SNVSSPATPTAS(ph)SSSSTTPTRK ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPT(0.008)AS(0.301)S(0.033)S(0.138)S(0.097)S(0.138)T(0.138)T(0.138)PT(0.008)RK 88.541 0.00025144 28585000.0 23689.0 20552.0 23197.0 23610.0 25942.0 17161.0 20074.0 18327.0 16166.0 22457.0 True False 22372.460214580526 22128.272314904363 21704.530274983957 20394.277270478262 22682.934035577455 19524.771977952423 21007.480775876375 18380.32853580183 19399.65171578002 21808.608059706752 1.0258545686790317 1.0146577101263157 0.9952276741166673 0.9351480486349064 1.0400908656562127 0.8952782279592658 0.9632655471804031 0.8428015435685252 0.889541031810394 1.0 14.4126100720663 -6.771826930017123 24.983175850177826 0.9111703704585549 0.9987761147130729 0.43255047085879006 0.04769989939543899 194.65335708900184 468159.42979792616 0.016485571616848937 0.014696255643292157 1.691114720737413e-07 6.771826930017123 0.08760574425451806 SNVSSPATPTASSSSS(ph)TTPTRK ddPTM_A459_Selumetinib_30min_R2 2 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPTASSSS(0.003)S(0.33)T(0.33)T(0.33)PT(0.006)RK;SNVSSPATPT(0.021)AS(0.206)S(0.133)S(0.086)S(0.057)S(0.215)T(0.141)T(0.141)PTRK 175.34 3.9739999999999997e-14 31205400.0 54333.0 52992.0 56585.0 64143.0 59048.0 58537.0 45754.0 52095.0 42854.0 68769.0 True False 51313.38937223198 57056.31600386392 52944.38270508971 55406.61274715321 51629.86234418234 66599.94040402072 47881.651659831026 52246.58782520848 51425.99744080398 66783.46028668007 0.7683547565813449 0.8543480041156803 0.792776871366299 0.82964573128302 0.7730935492493474 0.9972520159651572 0.716968714323732 0.7823282531472697 0.7700409236066623 1.0 16.027203226006797 -11.796502392108561 2.2823210116102586 1.7928611813973068 0.8117893995791219 0.38618884843846357 0.07202342591564535 4103014.55029669 706675.4920387908 16775949.882453742 0.0174580310771513 1.5977087288011814e-12 11.796502392108561 -0.9810717818181849 SNVSSPATPTASSSSST(ph)TPTR ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPT(0.002)AS(0.006)S(0.006)S(0.062)S(0.062)S(0.202)T(0.656)T(0.004)PTR 179.84 6.965800000000001e-14 4616700.0 9063.8 8370.9 9167.7 12253.0 8081.0 7706.8 8566.9 10309.0 6373.7 10726.0 True False 8560.070281266202 9012.921113314173 8577.860163037043 10584.120262396023 7065.792534943391 8768.341744635149 8965.277824990308 10338.997483253173 7648.6180960576 10416.312510505171 0.8217946871921429 0.8652698451802752 0.8235025739085696 1.0161100919083996 0.6783391462014338 0.8417894274765668 0.8606959339928165 0.9925775050264647 0.7342923024192807 1.0 13.346557017592733 -11.191104312524383 2.94410593154705 1.015563896057408 0.8523940900653206 0.18140184985119245 0.09634089634996393 101605389.21794687 100792390.57829659 11921850.74071765 0.024432577287651105 6.440145620686942e-12 11.191104312524383 -0.1631698059920874 SNVSSPATPTASSSSST(ph)TPTRK ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSS(0.001)PAT(0.031)PT(0.105)AS(0.065)S(0.054)S(0.054)S(0.056)S(0.115)T(0.343)T(0.152)PT(0.024)RK 52.739 0.045396 24196000.0 497.8 499.29 1463.7 1202.1 795.55 923.1 643.89 818.65 334.1 502.67 True False 509.39777144981605 440.83289468637656 1264.937579528587 992.1758012117018 723.5926429657599 913.8144521077402 595.320858901187 796.9367426500334 566.9432983014619 567.1925909204355 0.8981037122208694 0.7772190641118858 2.23017296025651 1.7492749677875854 1.275744173229625 1.6111184573564503 1.0495920934635363 1.4050549238606431 0.9995604797683112 1.0 9.147694876949899 -8.009136107435715 1.0849430697325684 0.9957499940625398 1.4269900613005497 0.1136386184342848 0.4052989511027344 1.2081465539519523 2.621279858565832 0.39836401697684687 0.14248358099356923 9.79183062370456e-09 8.009136107435715 0.4312400672380099 SNVSSPATPTASSSSSTT(ph)PTR ddPTM_A459_Selumetinib_30min_R1 3 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPTASSSS(0.001)S(0.003)T(0.08)T(0.916)PT(0.001)R;SNVSSPATPTASSSSST(0.009)T(0.981)PT(0.011)R;SNVSSPATPT(0.014)AS(0.047)S(0.158)S(0.063)S(0.063)S(0.063)T(0.063)T(0.527)PTR 287.48 3.5752999999999974e-86 30936600.0 5340.8 6826.0 6875.1 6639.8 5919.9 5046.1 5987.1 5883.4 2769.04 4973.9 True False 5465.230248612251 6026.808746678689 5941.499182221073 5480.283574482539 5384.446090243232 4995.340815492216 5535.488226758134 5727.353120023458 4698.858637320203 5612.348514888799 0.9737866837944466 1.0738479142359714 1.0586475815710805 0.9764688632475496 0.9593926813274384 0.8900624760276834 0.986305146958218 1.0204913513174685 0.8372357177845903 1.0 12.454388884690818 -5.920229257282127 3.9695489746852344 0.949994879508613 1.0388890479639263 0.3226665384368228 0.055795608501048165 0.25466080503259625 7.789663141244014 0.015870029296540474 0.024192190151853806 1.2016299454605574e-06 5.920229257282127 0.08889416845531328 SNVSSPATPTASSSSSTT(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTR 21 0 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPTASSSSS(0.001)T(0.028)T(0.97)PT(0.001)R 265.9 3.4384e-49 15767000.0 23986.0 20799.0 24376.0 27280.0 23976.0 23833.0 20019.0 23635.0 17576.0 23784.0 True False 22652.954143565723 22394.216420674195 22807.674698582083 23564.416939375144 20963.920531840467 27115.779415566714 20949.923166895947 23703.77393701511 21091.691114471705 23097.294121746672 0.9807622496453993 0.9695601702361095 0.9874608938329315 1.0202241360033886 0.9076353455664063 1.173980782018814 0.9070293280445816 1.0262576132109529 0.9131671876063334 1.0 14.495436227476777 -3.591023188238582 21.401005517667418 0.9902883718724869 0.7094722993456071 0.0 0.07501121365632736 0.0 0.0 0.01588266362996194 0.0 0.00025643471149526114 3.591023188238582 -0.2808160725268798 SNVSSPATPTASSSSSTT(ph)PTRK ddPTM_A459_Selumetinib_30min_R1 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPTAS(0.056)S(0.032)S(0.104)S(0.034)S(0.109)T(0.034)T(0.63)PT(0.001)RK 160.21 4.4789e-09 7440600.0 1810.3 1797.3 2078.6 2663.0 1860.3 1546.7 1876.7 1818.0 1034.9 1642.0 True False 1852.4764677693888 1586.8712804578981 1796.3375369325133 2197.957040701075 1692.0361934626412 1531.141602291237 1735.1390080601616 1769.7807343037446 1756.1497138945908 1852.7666944344303 0.9998433549858634 0.8564873738419081 0.9695433010149492 1.186310746681474 0.9132483860733188 0.8264082071912613 0.9365124131777556 0.955209708604991 0.9478525921099136 1.0 10.855465509268674 SNVSSPATPTASSSSSTT(ph)PTRK ddPTM_A459_Selumetinib_30min_R2 1 SNVSSPATPTASSSSSTTPTRK 22 1 A6NNK5;Q12888;Q12888-3;Q12888-2;H7BZY0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 SNVSSPATPT(0.002)AS(0.008)S(0.004)S(0.01)S(0.006)S(0.006)T(0.26)T(0.697)PT(0.006)RK 102.06 0.00013514 6824500.0 9458.8 11387.0 12431.0 13648.0 14578.0 7867.6 9526.3 10605.0 7642.5 10744.0 True False 8933.117762576485 12260.346285024138 11631.202993849432 11789.118855886807 12746.581311026455 8951.29048503808 9969.29182600534 10635.858794247737 9171.213549291646 10433.792803735556 0.8561716655306982 1.1750613142935549 1.1147626958516152 1.1298977349508044 1.2216632581071443 0.857913383312854 0.9554811000690071 1.0193664944582603 0.8789913430146058 1.0 13.348976068996576 -6.767721187357821 24.999941752974536 0.9443815413486955 1.1062439879709098 0.3765723671351602 0.10090476478735498 161.0220488570377 640821.5393481521 0.034562561551384124 0.0312141133516918 1.7071780282091673e-07 6.767721187357821 0.16186244662221438 SNVVS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 SNVVSPTK 8 0 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 SNVVS(0.916)PT(0.084)K 82.494 0.04118 11949000.0 5168.8 5030.5 2965.0 2614.6 3540.3 3338.1 4227.1 3939.1 1951.8 3586.7 True False 5289.222983265988 4441.526721383995 2562.369285579189 2158.009192120554 3220.080490090733 3304.521744752297 3908.246443742265 3834.6222719999328 3312.062046168194 4047.0878824165457 1.3069207135941299 1.0974623854058556 0.6331390273761932 0.5332251868056769 0.795653710432401 0.81651840552055 0.9656934954940051 0.9475016069357634 0.8183815480158383 1.0 11.982668462097871 -5.040732034481678 4.454353011945773 0.8076082504476219 1.2722275533358858 0.577807490959569 0.13793885979970827 0.1412757283806085 6.326210172877985 0.03936983455060712 0.13119388673779883 9.10474874561657e-06 5.040732034481678 0.4646193028882639 SNVVSPT(ph)KNEDNGAPENSVEKPHEKPEAR ddPTM_A459_Selumetinib_30min_R1 2 SNVVSPTKNEDNGAPENSVEKPHEKPEAR 29 3 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 SNVVS(0.022)PT(0.978)KNEDNGAPENSVEKPHEKPEAR;S(0.02)NVVS(0.207)PT(0.772)KNEDNGAPENS(0.001)VEKPHEKPEAR 86.039 2.0664e-06 110674000.0 3628.3 4126.1 4890.3 5012.8 3501.0 3571.4 3090.2 3488.8 2161.4300000000003 2834.8999999999996 True False 3712.8323305571885 3643.0142938281497 4226.2241204950815 4137.40858191001 3184.3351681517543 3535.474958571752 2857.1037260657063 3396.2656907804753 3667.788845398769 3198.787029264413 1.1607000705548642 1.1388736607031604 1.3211958413708262 1.2934304610024134 0.9954820808698909 1.105254875122075 0.8931834785896079 1.0617354827656265 1.146618643830817 1.0 11.643309227708967 -6.26623780722137 24.983440145370345 1.033349871489955 1.2287621166837632 0.5782955090582244 0.08150893490082653 307.50456070712943 1601047.2885477282 0.026171546888085036 0.030639893386166035 5.41704187475782e-07 6.26623780722137 0.1954122451938083 SNVVSPT(ph)KNEDNGAPENSVEKPHEKPEAR ddPTM_A459_Selumetinib_30min_R2 2 SNVVSPTKNEDNGAPENSVEKPHEKPEAR 29 3 Q71RC2-6;Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;X6RLN4;Q71RC2-2 Q71RC2-6 LARP4 La-related protein 4 1 S(0.013)NVVS(0.075)PT(0.902)KNEDNGAPENS(0.009)VEKPHEKPEAR;S(0.005)NVVS(0.111)PT(0.877)KNEDNGAPENS(0.007)VEKPHEKPEAR 41.69 0.030152 77833000.0 284790.0 281690.0 282380.0 303270.0 281950.0 218622.0 286950.0 277060.0 179233.0 314300.0 True False 268962.5119046977 303294.7172238917 264211.9782320975 261964.10283006914 246528.92033501886 248735.19604707867 300293.7435806384 277866.1987302479 215084.60818844492 305225.3423505296 0.8811932516265748 0.9936747548163261 0.8656292305134639 0.8582645884273331 0.8076947950537406 0.8149231454098067 0.9838427611157279 0.9103641152153688 0.7046748036453524 1.0 18.21951522614261 -5.328473830182379 13.792018664814883 0.8646771579023789 0.9374231960151848 0.09487174887265137 0.08502426929951439 4.397527359781511 902.5934778507166 0.021917613730439565 0.045632043909559 4.693817175774438e-06 5.328473830182379 0.07274603811280589 SPAAPYFLGSSFS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 SPAAPYFLGSSFSPVR 16 0 P30291 P30291 WEE1 Wee1-like protein kinase 1 SPAAPYFLGSSFS(1)PVR;SPAAPYFLGS(0.002)S(0.018)FS(0.98)PVR 194.32 1.2042e-06 42121000.0 2862.7 3142.9 2449.26 2453.87 2685.2 2314.1400000000003 2758.4 2780.67 1311.3600000000001 2567.39 True False 2929.395340155461 2774.9278069054303 2116.6639448221554 2025.3476693447797 2442.3241341105654 2290.861852671006 2550.3316671994185 2706.917598710886 2225.2821420550895 2896.9395149963534 1.0112034873324403 0.9578825489937519 0.7306552083207094 0.6991335714329987 0.843070461591477 0.7907869117777869 0.8803537850884777 0.9344059773075012 0.768149328122196 1.0 11.500313847652949 -9.500208924373585 10.758293600138767 0.9999999890196011 0.8436238955824867 0.18612267556598106 0.09636195937773386 0.0 0.0 0.09980212399190724 0.02420557052233083 3.1607567612907437e-10 9.500208924373585 -0.15637609343711434 SPAAPYFLGSSFS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 SPAAPYFLGSSFSPVR 16 0 P30291 P30291 WEE1 Wee1-like protein kinase 1 SPAAPYFLGS(0.05)S(0.056)FS(0.894)PVR;SPAAPYFLGSS(0.001)FS(0.999)PVR 152.68 0.00016493 24535000.0 28836.0 28787.0 26395.0 24074.1 31567.0 21988.4 29760.0 27665.0 24702.7 26493.7 True False 27233.41055965403 30994.870335205906 24696.774436703086 20795.1660498611 27601.271247439417 25017.10250917833 31143.898968321286 27745.5005698127 29643.930251107213 25728.758042100566 1.0584813505219088 1.2046780604212717 0.9598898787221357 0.8082460107803683 1.0727789970380543 0.9723400744117638 1.2104703583966159 1.078384760135413 1.152171053208249 1.0 14.65109419768812 -7.241479146511614 24.678658556903677 1.116788622295758 1.0124925471638435 0.16586769906351007 0.10673483097763395 1284.1950324854654 1587768.8883477098 0.043071279486274955 0.0333139487860621 5.7348340279812094e-08 7.241479146511614 -0.10429607513191441 SPAGLSGTPATQGLLGACS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 SPAGLSGTPATQGLLGACSPVR 22 0 P57059;A0A0B4J2F2 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 1 SPAGLSGTPATQGLLGACS(1)PVR 185.06 2.5595999999999992e-17 14063000.0 938.28 1080.3 1163.6 1374.4 1188.2 1068.4 1119.0 961.93 375.2 1084.5 True False 960.1400984249367 953.8179737821551 1005.5895111972832 1134.386840683274 1080.7275197937481 1057.652866029584 1034.592929087931 936.4164916110009 636.6869964762301 1223.7061389245664 0.7846165577535957 0.7794501828849221 0.8217573477902371 0.927009193302087 0.8831593512667407 0.8643029828706134 0.8454586409096269 0.7652298716372827 0.5202940282997778 1.0 10.257041435163142 -10.524297323127335 5.189094846593521 1.0000012657609683 0.8076530011996941 0.24411022345812483 0.10511208628108663 1.6113944726173856e-06 3.100950828266159e-07 0.10654664160960857 0.025841186317886202 2.990216797994061e-11 10.524297323127335 -0.19234826456127418 SPAGLSGTPATQGLLGACS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 SPAGLSGTPATQGLLGACSPVR 22 0 P57059;A0A0B4J2F2 P57059 SIK1;LOC102724428 Serine/threonine-protein kinase SIK1 1 SPAGLSGTPATQGLLGACS(1)PVR;SPAGLSGTPATQGLLGACS(1)PVR 205.13 5.1381e-23 10171800.0 25471.0 21424.0 24370.0 24854.0 28849.0 22320.0 20514.4 19667.6 20224.7 23570.0 True False 24055.423788491746 23067.151910982448 22802.06073204978 21468.84232445856 25224.730706667706 25394.377399213237 21468.360248512417 19724.829459853543 24270.205125333192 22889.472857785448 1.050938304169365 1.0077624790357094 0.9961811210647459 0.9379352009479028 1.1020232254098399 1.1094347850206516 0.9379141399147747 0.8617424080670557 1.0603217154071818 1.0 14.482396617706662 -7.3037061058223065 24.97282492143647 0.9534730759743858 1.029851297976596 0.19612435466016065 0.06655459159218918 771.2095391800605 455657.37418288767 0.028736482313381415 0.019374251570581452 4.969284873264189e-08 7.3037061058223065 0.07637822200221012 SPAGPAATPAQAQAAS(ph)TPR ddPTM_A459_Selumetinib_30min_R1 1 SPAGPAATPAQAQAASTPR 19 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SPAGPAATPAQAQAAS(0.5)T(0.5)PR 148.4 2.4146e-05 9424000.0 4758.7 5809.0 4028.8 4907.4 4727.4 4683.5 5006.5 4292.4 2935.6 4449.6 True False 4869.568451181681 5128.879579469168 3481.7110886143155 4050.4147133069687 4299.80750469026 4636.38824227776 4628.855674243729 4178.551608319797 4981.498792259121 5020.749502774324 0.9698887483812715 1.0215366404229276 0.6934644093855749 0.8067350723370732 0.8564074949993637 0.9234454417046344 0.9219451541420168 0.8322565397877045 0.9921823005721527 1.0 12.293687031950194 -6.766331733086435 23.554554195135562 0.9227306482425668 0.8647685070077914 0.09904552620076867 0.09348271055893036 177.8154303021231 856094.1084419091 0.03456411986026674 0.031495478378181875 1.712648611969151e-07 6.766331733086435 -0.05796214123477539 SPAGPAATPAQAQAAST(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 SPAGPAATPAQAQAASTPR 19 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SPAGPAATPAQAQAAS(0.234)T(0.766)PR;SPAGPAATPAQAQAAS(0.037)T(0.963)PR;SPAGPAATPAQAQAAS(0.085)T(0.915)PR;SPAGPAATPAQAQAAS(0.232)T(0.768)PR 240.42 1.872e-29 288554000.0 10378.5 13295.399999999998 8927.1 9375.1 10126.400000000001 10262.199999999999 11233.1 9700.2 5542.12 10135.3 True False 10620.29885695443 11738.768387136222 7714.848853050245 7737.914777422705 9210.46890796113 10158.971585332083 10385.77822317931 9442.91918530978 9404.572859570479 11436.264481182256 0.9286510358718573 1.0264512862964756 0.6745951762259963 0.6766120869410652 0.8053738983665909 0.8883120534723652 0.9081442843743721 0.8256996155385864 0.8223465691131213 1.0 13.48132826955571 -6.763078034454977 24.833289979118927 0.8792094723243927 0.8173727194074971 0.08156844626566429 0.1086493417222284 136.2615925726784 2064979.1317602177 0.04108028120667814 0.0381312803768033 1.7255278196168155e-07 6.763078034454977 -0.06183675291689561 SPAGPAATPAQAQAAST(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 SPAGPAATPAQAQAASTPR 19 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 SPAGPAATPAQAQAAS(0.252)T(0.748)PR;SPAGPAATPAQAQAAS(0.011)T(0.989)PR;SPAGPAATPAQAQAAS(0.248)T(0.752)PR;SPAGPAATPAQAQAAS(0.223)T(0.777)PR;SPAGPAATPAQAQAAS(0.238)T(0.762)PR 239.1 2.2910999999999998e-29 368412200.0 144867.6 122909.4 142337.7 148708.5 154938.2 125424.4 139656.8 146670.1 126652.0 143370.5 True False 136816.43874295094 132336.1557639894 133179.84734757 128454.14576352903 135473.4781509178 142700.47261065774 146151.11792469918 147096.88570845782 151985.938952553 139231.02114370544 0.982657726841906 0.9504789570378889 0.9565386093815271 0.92259716770264 0.9730121709808525 1.0249186671077515 1.0497022626434036 1.056495057639732 1.09160974116309 1.0 17.087121158785372 -6.8214883587982404 2.377878648250559 1.0535882036625868 0.9524230331102846 0.7602933264111259 0.024979310791968367 0.1330535534453426 1.5398197773108564 0.009605717463729423 0.008549005585924224 1.5083830419912994e-07 6.8214883587982404 -0.10116517055230212 SPAGSQQQFGYSPGQQQTHPQGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SPAGSQQQFGYSPGQQQTHPQGSPR 25 0 Q8TAP9 Q8TAP9 MPLKIP M-phase-specific PLK1-interacting protein 1 SPAGSQQQFGYSPGQQQT(0.083)HPQGS(0.917)PR 111.81 9.7666e-07 0.0 633.73 587.33 517.11 816.79 768.39 701.17 701.41 417.2 204.9 459.33 True False 648.4946759760787 518.5651305576908 446.8893022819073 674.1529595472146 698.8892601702726 694.1168664114219 648.5020789915693 406.1345007434116 347.7003346961076 518.2894797530855 1.2512209900247702 1.0005318471923001 0.8622388061876282 1.3007266901662422 1.3484534945668303 1.3392455249952229 1.2512352735782277 0.7836055266583747 0.6708612624391931 1.0 9.017614299950958 -7.76592200452351 24.998405309836848 0.7954249088124556 1.1889290229070113 0.5230821659369712 0.1637165232442106 96.91059414079606 540429.926467621 0.09476735111771976 0.04795738442329667 1.7142651468366492e-08 7.76592200452351 0.39350411409455566 SPAGSQQQFGYSPGQQQTHPQGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SPAGSQQQFGYSPGQQQTHPQGSPR 25 0 Q8TAP9 Q8TAP9 MPLKIP M-phase-specific PLK1-interacting protein 1 SPAGSQQQFGYSPGQQQT(0.044)HPQGS(0.956)PR;SPAGSQQQFGYSPGQQQT(0.009)HPQGS(0.991)PR 154.25 6.8367e-11 25431400.0 17479.2 15280.8 22809.1 23746.7 25282.6 17502.1 14934.8 16307.3 17048.0 23071.4 True False 16507.776038781554 16452.78822448377 21341.587338670368 20512.358494657616 22106.373758688238 19912.855406754923 15629.297792744774 16354.751543181153 20458.076360919076 22405.268735303827 0.7367809881597343 0.7343267522856901 0.9525253899339567 0.915514950389166 0.9866596120695208 0.8887577132863563 0.6975724316181844 0.729951143920496 0.9130922107032542 1.0 14.451550410247188 -12.543919364411307 1.1705389004095106 3.502958604896766 0.840312784767809 0.1855316748162309 0.10090124397294388 221020.93503842028 4982.737246182301 1461758.8021724878 0.03250436680233659 2.858121162339808e-13 12.543919364411307 -2.662645820128957 SPALKS(ph)PLQSVVVR ddPTM_A459_Selumetinib_30min_R2 1 SPALKSPLQSVVVR 14 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.024)PALKS(0.94)PLQS(0.037)VVVR 64.53399999999999 0.041048 81897000.0 101630.0 98077.0 99948.0 92732.0 113250.0 83589.0 87471.0 86836.0 72921.0 96939.0 True False 95981.81145712433 105599.19053273994 93517.45449515416 80101.74162837742 99022.5225321544 95102.62600460734 91538.5748204984 87088.67838352628 87507.23758297611 94140.1191922303 1.0195633092532355 1.1217235694923084 0.9933857668503193 0.8508778437470736 1.0518631523076196 1.0102241936874081 0.9723651893150926 0.9250963258894408 0.9295424557970857 1.0 16.522522059195808 -5.507346006552783 24.38024651001021 0.9624507735881724 1.0673712823909227 0.36150042942351945 0.05652585019651824 525.0679511235298 824146.5928391434 0.015146341780582218 0.03000304766899087 3.1092381903566293e-06 5.507346006552783 0.10492050880275028 SPAPEQFQS(ph)REDFR ddPTM_A459_Selumetinib_30min_R1 1 SPAPEQFQSREDFR 14 1 Q9P0V3-2;Q9P0V3 Q9P0V3-2 SH3BP4 SH3 domain-binding protein 4 1 SPAPEQFQS(1)REDFR 115.1 0.017799000000000002 0.0 665.67 872.66 1029.9 1005.6 1209.5 685.55 743.93 881.68 385.46 641.15 True False 681.1788158316573 770.4885615113727 890.0452368357529 829.9908374498697 1100.1009385545683 678.6539894295973 687.8147611585205 858.2949822997381 654.0974671154785 723.4478478298629 0.9415728001334158 1.065022950614365 1.2302825138061224 1.1472711404693585 1.520636134110506 0.938082809238241 0.9507454659264915 1.1863951007310038 0.9041390738497381 1.0 9.49874520875824 SPAPGAPTRS(ph)PSTPAK ddPTM_A459_Selumetinib_30min_R1 2 SPAPGAPTRSPSTPAK 16 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 SPAPGAPT(0.001)RS(0.972)PS(0.022)T(0.004)PAK;SPAPGAPT(0.307)RS(0.682)PS(0.006)T(0.006)PAK 125.45 0.0057156 44892100.0 5629.1 6814.0 8317.7 8368.6 7735.4 5787.6 6305.4 6494.6 3390.1000000000004 5343.1 True False 5760.247077678101 6016.213712257342 7188.2020258556595 6907.181108077741 7035.734435795787 5729.381998720351 5829.778601493337 6322.342110566061 5752.752096892507 6028.938931201337 0.9554329780763435 0.9978893103597154 1.1922831045202387 1.1456711018138317 1.1669938136848625 0.9503134903339788 0.9669659401130615 1.0486658071532762 0.9541898106017477 1.0 12.557688400652596 -6.773453215337543 24.999956398065702 0.986002298032688 1.0950363642651988 0.3531769062473016 0.07272971876240697 285.216567365702 593511.9612535377 0.02803087978193051 0.024910951715882684 1.6847939125454346e-07 6.773453215337543 0.10903406623251077 SPAPGAPTRS(ph)PSTPAK ddPTM_A459_Selumetinib_30min_R2 4 SPAPGAPTRSPSTPAK 16 1 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 SPAPGAPT(0.011)RS(0.987)PS(0.001)T(0.001)PAK;SPAPGAPT(0.002)RS(0.997)PS(0.001)T(0.001)PAK;SPAPGAPT(0.005)RS(0.97)PS(0.01)T(0.015)PAK;SPAPGAPT(0.016)RS(0.973)PS(0.006)T(0.006)PAK 110.34 0.0015470999999999998 131482000.0 214914.0 215421.0 211215.0 260338.0 238284.0 200026.0 203661.0 191121.0 156726.0 224283.0 True False 202969.9402489069 231943.09801231124 197625.65685350454 224879.51529190072 208348.6336340119 227577.7658447591 213131.64004661562 191677.13046821504 188075.57929032118 217807.3670327831 0.9318782142862828 1.064900150863127 0.9073414712540878 1.0324697385376003 0.9565729409081579 1.0448579813671106 0.978532741799024 0.8800305199932237 0.8634950316534203 1.0 17.732693226480222 -7.684304219303761 6.1978963467011585 0.9041811235475877 0.9913053649726449 0.24966001279801908 0.0576692404733275 0.23016715031401946 14.301227248168438 0.025781683682817913 0.014575026049893096 2.068691741529034e-08 7.684304219303761 0.08712424142505715 SPAPPPPAVFPAARPEPGDGLS(ph)SPAGGSYETGDR ddPTM_A459_Selumetinib_30min_R2 1 SPAPPPPAVFPAARPEPGDGLSSPAGGSYETGDR 34 1 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 SPAPPPPAVFPAARPEPGDGLS(0.494)S(0.494)PAGGS(0.008)YET(0.004)GDR 61.203 0.00023647 3809500.0 7248.5 6743.5 7487.6 8323.1 8905.2 6567.4 7948.0 5799.2 7977.8 6940.4 True False 6845.657388044533 7260.70476622993 7005.855967882472 7189.479421851661 7786.449162501908 7471.999737078539 8317.597748663218 5816.074711890756 9573.582918356413 6740.012618675184 1.0156742687805405 1.0772538831918528 1.039442559568908 1.0666863444633763 1.155257356778126 1.10860322670245 1.234062637452172 0.8629174811595475 1.420410236596589 1.0 12.718535577090448 -6.1120224176434395 4.897647928959231 1.127221834255072 1.048185427090911 0.07790830471634069 0.13659198146341245 0.660037933160834 24.06653155108377 0.037830702168228106 0.049771335521845386 7.726407014878764e-07 6.1120224176434395 -0.07903640716416094 SPART(ph)PPSEEDSAEAER ddPTM_A459_Selumetinib_30min_R1 2 SPARTPPSEEDSAEAER 17 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 S(0.002)PART(0.998)PPSEEDSAEAER;S(0.021)PART(0.979)PPSEEDSAEAER 102.29 0.00504 34129000.0 1147.69 1705.19 1423.72 1971.9299999999998 1670.9699999999998 1185.91 1321.78 1565.27 863.51 1025.08 True False 1174.4289439840088 1505.5455620786765 1230.3866439341666 1627.5694432105415 1519.8310585337142 1173.9808221201276 1222.0770704288175 1523.7539548864793 1465.313401724919 1156.6590031247529 1.0153631630508644 1.301633029277769 1.0637418985286382 1.4071298790858917 1.3139836844116026 1.0149757352413973 1.0565577816169982 1.31737525992536 1.2668499512529847 1.0 10.175747888078293 -6.740082434840733 24.999681440645745 1.1463254619347945 1.2265588272628436 0.08208883798055255 0.14405015784588004 762.0260528190001 891998.208054998 0.0488718417795237 0.048825930219979816 1.8193554880815072e-07 6.740082434840733 0.08023336532804914 SPAS(ph)PLNNQGIPTPAQLTK ddPTM_A459_Selumetinib_30min_R1 2 SPASPLNNQGIPTPAQLTK 19 0 A0A2U3U043;J3QLL6;J3KSG1;J3QRK1;Q719H9 A0A2U3U043 KCTD1 BTB/POZ domain-containing protein KCTD1 1 S(0.028)PAS(0.972)PLNNQGIPTPAQLTK;S(0.015)PAS(0.985)PLNNQGIPTPAQLTK 190.55 1.4635e-15 15196000.0 2893.54 3483.7 3463.3 3968.5 3526.4 2907.69 3010.93 2855.16 1802.1999999999998 2846.7799999999997 True False 2960.953852151266 3075.826784471808 2993.002882545163 3275.475972971167 3207.4377426364854 2878.4412785712875 2783.8131259863503 2779.4318819332657 3058.2017725198866 3212.1919429854097 0.9217860902170611 0.9575476307350226 0.9317633988470402 1.01970119815659 0.9985199513499478 0.8960987791707321 0.8666397199785875 0.8652757778073694 0.9520607195339627 1.0 11.649342387641708 -6.775380630016021 24.990657666338826 0.9045087669599396 0.9664981697142995 0.20462801159620403 0.04643870321052078 307.75265768658903 551664.5699467259 0.01646637237809209 0.014593235161594487 1.6773333034647148e-07 6.775380630016021 0.061989402754359824 SPAS(ph)PLNNQGIPTPAQLTK ddPTM_A459_Selumetinib_30min_R2 2 SPASPLNNQGIPTPAQLTK 19 0 A0A2U3U043;J3QLL6;J3KSG1;J3QRK1;Q719H9 A0A2U3U043 KCTD1 BTB/POZ domain-containing protein KCTD1 1 S(0.25)PAS(0.75)PLNNQGIPTPAQLTK;S(0.415)PAS(0.585)PLNNQGIPTPAQLTK 143.23 7.846800000000001e-05 15878900.0 76164.0 80754.0 83718.0 89026.0 86031.0 69879.0 73854.0 73737.0 71361.0 83447.0 True False 71931.10978864915 86947.5721349642 78331.6750252666 76900.50522158411 75223.01665310166 79504.1979515959 77288.3573389246 73951.56246218247 85635.19399293435 81037.66828865602 0.88762561050536 1.0729278614638456 0.9666082043013543 0.9489476541657722 0.9282475451435427 0.9810770673756567 0.9537337261929061 0.912557876156643 1.0567331933577107 1.0 16.306305043362883 -8.271566684790033 24.97306438294763 1.0283665963268527 0.9602239559441221 0.25753074697948974 0.04849892346497294 1105.0351175252883 2724890.809824833 0.04362633533596849 0.011763608995070356 5.350979845568887e-09 8.271566684790033 -0.06814264038273055 SPASDTYIVFGEAK ddPTM_A459_Selumetinib_30min_R2 1 SPASDTYIVFGEAK 14 0 E9PAV3;F8VZJ2;F8W0W4;H0YHX9;Q13765;E9PAV3-2;F8W1N5;F8VNW4 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alpha 0 130.1 0.013836 4494400.0 21341.0 18777.0 20466.0 17931.0 21205.0 15516.0 14830.0 16814.0 11145.0 15813.0 False True 20154.9526547918 20217.135522428933 19149.239841695977 15488.766867299686 18541.03832489476 17653.188159775655 15519.624385087507 16862.92595629246 13374.311417318346 15356.437602891863 1.312475795232372 1.3165250981530847 1.2469845114396758 1.0086171850418553 1.2073788729101589 1.1495627186640784 1.0106266040611471 1.0981014211992044 0.870925390586665 1.0 13.90655595701982 -4.688821650195828 0.28699053381911377 0.9540939000633589 1.674673997770229 0.6679010814067281 0.08181242999818748 5.358420399908149 0.35013630792560274 0.09930601254339967 1.378909152550511 2.0472852137263682e-05 4.688821650195828 0.72058009770687 SPASPSCPS(ph)PVPQR ddPTM_A459_Selumetinib_30min_R2 3 SPASPSCPSPVPQR 14 0 A7MCY6 A7MCY6 TBKBP1 TANK-binding kinase 1-binding protein 1 1 SPAS(0.003)PS(0.02)CPS(0.976)PVPQR;SPAS(0.019)PS(0.119)CPS(0.862)PVPQR;SPASPS(0.01)CPS(0.99)PVPQR 118.16 0.0030042 3805500.0 14326.900000000001 24153.1 21183.7 22259.9 19212.8 15709.4 15629.6 16974.800000000003 12928.9 16528.8 True False 13530.668253124815 26005.565105542835 19820.763805068636 19228.06321953067 16799.11629938873 17873.227254265235 16356.407369464854 17024.19385767059 15515.041263648918 16051.570597020129 0.8429498017867919 1.620125890383001 1.2348177198777193 1.197892947815352 1.0465714988978947 1.1134877516336803 1.0189910869221306 1.060593650619524 0.9665746519863412 1.0 13.970426847094737 -6.150445113400201 2.195596314153499 1.036088747197736 1.2697266968736465 0.20708425873792746 0.1785980826625207 0.4406909461356424 4.171799066726483 0.05593495124930973 0.07788088395993209 7.072205743240499e-07 6.150445113400201 0.23363794967591045 SPAVATSTAAPPPPS(ph)SPLPSK ddPTM_A459_Selumetinib_30min_R2 3 SPAVATSTAAPPPPSSPLPSK 21 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 SPAVATSTAAPPPPS(0.493)S(0.493)PLPS(0.013)K;SPAVATSTAAPPPPS(0.596)S(0.397)PLPS(0.007)K;SPAVATSTAAPPPPS(0.625)S(0.375)PLPSK 118.05 4.9922e-05 156777700.0 184983.0 180491.0 204685.0 228970.0 212505.0 173505.0 199504.0 202585.0 169176.0 211943.0 True False 174702.38540562062 194334.07932996334 191515.7899441776 197783.89100471832 185808.22208119597 197403.7388284268 208781.3313096765 203174.4888102479 203015.92717238638 205823.65489595314 0.8487964393302374 0.9441775748671942 0.9304848368424496 0.9609385816450542 0.9027544583013296 0.9590916016345025 1.014369953809335 0.9871289522720581 0.9863585761073668 1.0 17.651049272217513 -1.522878746057372 0.2320291460719425 1.0072640708575196 0.25655574681621657 0.6687280146863654 0.027191322213527665 32.949295859834415 0.4331774602728513 0.041145872896959826 9.420589843800347 0.02999999994632436 1.522878746057372 -0.750708324041303 SPAVATSTAAPPPPSS(ph)PLPSK ddPTM_A459_Selumetinib_30min_R1 4 SPAVATSTAAPPPPSSPLPSK 21 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 SPAVATSTAAPPPPS(0.208)S(0.791)PLPS(0.001)K;SPAVATSTAAPPPPS(0.306)S(0.694)PLPSK;SPAVATSTAAPPPPS(0.227)S(0.773)PLPSK;SPAVATSTAAPPPPS(0.228)S(0.772)PLPSK 281.53 5.4280999999999986e-73 595793000.0 20463.1 24649.1 26304.800000000003 27969.5 24631.300000000003 20634.4 24280.1 21232.6 12733.900000000001 17723.6 True False 20939.8504157387 21763.171912944297 22732.75264192361 23085.151877539905 22403.403264009212 20426.83667053619 22448.632508979354 20669.442474795193 21608.498252741647 19998.596702483595 1.0470659880419615 1.0882349515174514 1.1367173897306737 1.1543385879006698 1.1202487653159667 1.0214135008782599 1.1225103862508259 1.0335446422712393 1.0805007258363344 1.0 14.28761114947962 -6.740902059335923 24.944290495026983 1.0581226686014822 1.112172679966402 0.3191189559268576 0.041513820658267885 316.11954858140746 383952.469397031 0.01387996182969076 0.013863773348813363 1.8159251380680146e-07 6.740902059335923 0.054050011364919825 SPAVATSTAAPPPPSS(ph)PLPSK ddPTM_A459_Selumetinib_30min_R2 6 SPAVATSTAAPPPPSSPLPSK 21 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 SPAVATSTAAPPPPS(0.212)S(0.788)PLPSK;SPAVATSTAAPPPPS(0.198)S(0.791)PLPS(0.011)K;SPAVATSTAAPPPPS(0.229)S(0.771)PLPSK;SPAVATSTAAPPPPS(0.219)S(0.78)PLPS(0.001)K;SPAVATSTAAPPPPS(0.233)S(0.767)PLPSK;SPAVATSTAAPPPPS(0.231)S(0.766)PLPS(0.003)K 216.53 2.6525e-20 834041000.0 619322.0 599709.0 649824.0 656884.0 675266.0 521689.0 528552.0 546123.0 494063.0 644590.0 True False 584902.5625823984 645704.751931635 608015.0313148762 567415.2660118964 590433.0481253657 593546.9243287706 553130.715305919 547712.1275144706 592889.4052736238 625979.0118540484 0.934380468843535 1.0315118234062868 0.9713025833151087 0.9064445536780928 0.9432154064983725 0.9481898164137817 0.8836250175028 0.8749688362429853 0.9471394312687601 1.0 19.255754760984978 -5.6379704182521 5.369519709849857 0.9235485478319213 0.9871083320722814 0.23501685614476453 0.04053724417361893 0.24044503963296765 10.285147654926073 0.010854603846766238 0.019107962262908056 2.3015985842871574e-06 5.6379704182521 0.06355978424036013 SPAVQS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 SPAVQSPAK 9 0 A0A087WT04;U3KQ54 A0A087WT04 PMF1-BGLAP 1 SPAVQS(1)PAK 80.17 0.047087 7162300.0 60372.0 60406.0 66717.0 72481.0 67317.0 44800.0 64716.0 66282.0 46268.0 69736.0 True False 57016.765928264416 65038.945964096565 62424.500855977225 62608.96276330088 58860.03663838443 50970.79334609107 67725.4222323213 66474.86964642412 55522.89283593409 67722.54048411219 0.8419171153456748 0.9603736879799245 0.9217684453320546 0.9244922342803875 0.8691350947206873 0.7526414836438231 1.0000425522756309 0.9815767272053124 0.8198583874590447 1.0 16.047348473797236 -10.717622446943134 5.217880178857046 1.000006237439406 0.9007484532401384 0.1490157715171152 0.07341165557275463 5.405010121092513e-06 8.341298112031133e-07 0.07212385563446969 0.017491505177694884 1.9159208032330742e-11 10.717622446943134 -0.09925778419926767 SPCETIS(ph)SPSSTLESK ddPTM_A459_Selumetinib_30min_R1 1 SPCETISSPSSTLESK 16 0 Q9C0D5 Q9C0D5 TANC1 Protein TANC1 1 SPCET(0.006)IS(0.963)S(0.03)PS(0.001)STLESK 207.31 7.2222e-08 13962000.0 2280.5 2088.9 2855.4 3020.3 2450.0 2316.0 2259.1 2315.8 1075.0 1975.6 True False 2333.6312129194575 1844.3306168967363 2467.652363589484 2492.861303052745 2228.3979325826317 2292.703142759749 2088.6942681881546 2254.377461221457 1824.1964851064704 2229.1875039736033 1.0468528146509344 0.8273555336234182 1.1069738903483035 1.1182824677642118 0.9996458030607277 1.0284927305006542 0.9369755861563845 1.011300062109155 0.8183234841639734 1.0 11.12230225598195 -7.5327326014822 1.5666397249935495 0.9272353888716076 1.0200135100314285 0.15284132725247712 0.08934838623086076 0.8119576237194401 3.848115198362565 0.061740733295750326 0.029361974279187797 2.9326983748616817e-08 7.5327326014822 0.09277812115982087 SPCETISS(ph)PSSTLESK ddPTM_A459_Selumetinib_30min_R2 1 SPCETISSPSSTLESK 16 0 Q9C0D5 Q9C0D5 TANC1 Protein TANC1 1 SPCETIS(0.052)S(0.794)PS(0.112)S(0.035)T(0.008)LESK 125.39 0.0012093 7326900.0 62862.0 57024.0 65460.0 76819.0 66207.0 50205.0 53935.0 58756.0 51704.0 59394.0 True False 59368.381696524164 61397.55743894058 61248.37486745913 66356.11967983343 57889.48476191032 57120.28303438621 56443.084370174976 58926.9702324206 62046.24473046456 57679.14089585532 1.029286857855926 1.064467266421308 1.0618808448976098 1.1504352986055244 1.0036467926322756 0.9903109191158346 0.9785701294006415 1.0216339792372835 1.075713746196297 1.0 15.815762056012383 SPCETISSPS(ph)STLESK ddPTM_A459_Selumetinib_30min_R2 1 SPCETISSPSSTLESK 16 0 Q9C0D5 Q9C0D5 TANC1 Protein TANC1 1 SPCET(0.002)IS(0.224)S(0.224)PS(0.366)S(0.075)T(0.107)LESK 86.641 0.015357 8455000.0 30852.0 24479.0 29544.0 27197.0 30138.0 23350.0 22333.0 25990.0 18855.0 25475.0 True False 29137.369350341443 26356.460587609166 27643.171205075043 23492.721682558127 26351.7950028615 26566.250549804157 23371.52875199997 26065.62659712389 22626.526852717565 24739.47055800105 1.1777685089108771 1.0653607370382938 1.1173711717179373 0.9496048683612711 1.06517214833197 1.0738407067976765 0.9447061002055814 1.0536048674127323 0.9145922019499269 1.0 14.594527005509672 -1.5228787455262136 0.3672637218986362 0.9872165591918276 3.3154244453807546 0.48921330581375244 0.0562789353610113 56.64935257805212 0.78497850007668 0.043243589962102834 92.8153258148893 0.029999999983015484 1.5228787455262136 2.328207886188927 SPDASSAFSPAS(ph)PATPNGTK ddPTM_A459_Selumetinib_30min_R2 1 SPDASSAFSPASPATPNGTK 20 0 Q53GS7-2;Q53GS7 Q53GS7-2 GLE1 Nucleoporin GLE1 1 SPDASS(0.004)AFS(0.394)PAS(0.602)PAT(0.001)PNGTK 154.52 3.487e-06 6036300.0 23957.0 17071.0 24437.0 23248.0 29439.0 21211.0 23126.0 19652.0 18429.0 23455.0 True False 22625.565847469534 18380.290808083508 22864.750024993853 20081.5822949631 25740.609632000796 24132.62271571288 24201.404823299665 19709.184066436275 22115.31494928307 22777.793206591326 0.9933168521752256 0.8069390498621574 1.0038176138317634 0.8816298450348558 1.1300747793492174 1.05948027962294 1.062499979861806 0.8652806655884876 0.9709156084042175 1.0 14.475340359952476 -6.217087652074168 24.99913045960172 1.012600922234196 0.9191333313932999 0.23256759951552886 0.08291931097509342 730.4093441620059 411699.4687011886 0.02539140430203734 0.03278006643446969 6.066138865605502e-07 6.217087652074168 -0.09346759084089618 SPDASSAFSPASPAT(ph)PNGTK ddPTM_A459_Selumetinib_30min_R2 1 SPDASSAFSPASPATPNGTK 20 0 Q53GS7-2;Q53GS7 Q53GS7-2 GLE1 Nucleoporin GLE1 1 SPDASSAFSPAS(0.061)PAT(0.938)PNGTK 133.35 0.00031266 3352100.0 17201.0 20058.0 20295.0 21542.0 21149.0 16718.0 15944.0 21151.0 14698.0 18778.0 True False 16245.037281058703 21596.38410336471 18989.241795525253 18607.94243797724 18492.073545541112 19020.752749106043 16685.42759243663 21212.545908263455 17638.010696432928 18235.8303488967 0.890830687182915 1.184283012628012 1.0413148966739612 1.020405546770348 1.0140516330620457 1.0430428658959767 0.9149804134609164 1.1632344402429062 0.9672173056545275 1.0 14.15448827228416 -5.5278584958427714 22.78194049331196 1.0217625237346877 1.0563672913437074 0.0015933725487132788 0.08896317313955891 195.54565972006762 894596.7408605146 0.022709456687439795 0.03958603278765843 2.965797564181717e-06 5.5278584958427714 0.03460476760901976 SPDEATAADQES(ph)EDDLSASR ddPTM_A459_Selumetinib_30min_R2 1 SPDEATAADQESEDDLSASR 20 0 C9JME2;Q9Y4F1;Q9Y4F1-2;M0QXT1 C9JME2 FARP1 FERM, RhoGEF and pleckstrin domain-containing protein 1 1 SPDEATAADQES(1)EDDLSASR 246.61 3.088299999999998e-81 0.0 11385.0 5807.6 8992.0 10435.0 10733.0 6874.4 11626.0 12347.0 11866.0 7785.5 True False 10752.267277766017 6253.024245622739 8413.464509749352 9013.734998620956 9384.624585762578 7821.28620041001 12166.632036481958 12382.927725844118 14239.531563741542 7560.712385841695 1.422123568395602 0.8270416763018584 1.1127872719380958 1.1921806489425801 1.2412354956573097 1.0344641881969043 1.6091912263803843 1.6377990715574073 1.8833584505088046 1.0 12.884306459201143 -7.267119606133683 24.439519831946583 1.5857371495408865 1.130124706398655 0.3617251556766148 0.2525267807235995 325.16530345509517 1399034.572045095 0.09824822558596111 0.0683811863216281 5.406054179257177e-08 7.267119606133683 -0.4556124431422315 SPDEEDYDYES(ph)YEK ddPTM_A459_Selumetinib_30min_R1 1 SPDEEDYDYESYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SPDEEDYDYES(1)YEK 233.62 1.1737999999999994e-64 0.0 561.89 803.06 658.85 771.99 584.3 583.09 852.72 671.49 497.94 708.75 True False 574.9809437523851 709.0373618675347 569.3817888039964 637.1764385470613 531.4501681665437 577.2246440033607 788.3986438711893 653.6799038930811 844.967811901317 799.7249663096238 0.7189733570600744 0.8866015089405397 0.7119720063654396 0.796744462646137 0.6645411742226213 0.7217789469134577 0.985837227902612 0.8173808889692716 1.056573006343004 1.0 9.64336011732046 -7.260542478507733 24.99984007703792 0.9497295271392886 0.752804247131382 0.6312032752073349 0.08009979735061827 57.21782328018836 1594895.7245793012 0.031205742592167903 0.022743219532410652 5.4885486927894366e-08 7.260542478507733 -0.19692528000790654 SPDEEDYDYES(ph)YEK ddPTM_A459_Selumetinib_30min_R2 1 SPDEEDYDYESYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SPDEEDY(0.027)DY(0.382)ES(0.59)YEK 80.53399999999998 0.033776 4802200.0 11321.0 11878.0 14847.0 15156.0 15496.0 9986.5 16573.0 13197.0 9569.2 11004.0 True False 10691.824141553729 12789.004406210295 13891.760184191346 13091.726654441709 13549.253944002316 11362.049726578976 17343.67733877649 13235.401085119041 11483.307385787597 10686.285928174419 1.0005182542762316 1.1967679409075191 1.2999614906022388 1.2250960476291712 1.2679104821891087 1.063236544759008 1.6229845856032958 1.238540796501044 1.0745835796431227 1.0 13.383472903885343 -4.783260725581535 3.5778452594319172 1.2430636439582035 0.9730323042399912 0.13358847765529225 0.1638497788821047 0.5091028124853266 10.972249427897852 0.04042981616746013 0.37093935936606837 1.6471732259878088e-05 4.783260725581535 -0.27003133971821225 SPDEEDYDYESYEK ddPTM_A459_Selumetinib_30min_R1 2 SPDEEDYDYESYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 ; 227.31 5.4018e-12 12594600.0 2833.7 3732.7 3082.0 3453.8 3187.0 2646.61 2779.99 2775.2 1718.48 2481.74 False True 2899.719696579638 3295.6737487148484 2663.481328214188 2850.658665855567 2898.7364127105498 2619.987506329614 2570.29311611721 2701.5926808799504 2916.1350471867595 2800.2955031947013 1.0355048934198228 1.1769021322767534 0.9511429508691388 1.0179849457328376 1.0351537576671972 0.935611082237791 0.9178649586034423 0.9647527119183864 1.041366899978914 1.0 11.451363361296206 -5.273252227855774 24.973799310632923 0.9808214038556197 1.1062035165208135 0.4873943960047268 0.05050723349704649 528.7035892205542 1117744.568070759 0.013365038632835141 0.028191124204940465 5.330252372563839e-06 5.273252227855774 0.12538211266519383 SPDEEDYDYESYEK ddPTM_A459_Selumetinib_30min_R2 4 SPDEEDYDYESYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 ;;; 238.01 7.597800000000001e-39 20256000.0 64552.0 65957.0 71175.0 73298.0 74911.0 54254.0 57613.0 61034.0 50964.4 69432.0 False True 60964.458262130225 71015.68981481853 66595.67798948062 63314.68595389727 65500.01046716302 61726.996031223774 60292.118657993706 61211.59883527738 61158.70406431393 67427.31775399909 0.9041507254456144 1.053218371727483 0.987666130105418 0.9390064452050979 0.9714165215073862 0.9154597585570244 0.8941794018555307 0.907816013957443 0.9070315430230299 1.0 16.041045588219887 -6.392651147344321 1.417776748350387 0.9178876972138462 0.984222179838002 0.17647169589361955 0.04550922183591456 0.547964540874411 2.232616147122434 0.017544757161565963 0.021782031184191766 4.0490100306891234e-07 6.392651147344321 0.06633448262415576 SPDKPGGS(ph)PSASR ddPTM_A459_Selumetinib_30min_R1 4 SPDKPGGSPSASR 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 SPDKPGGS(0.98)PS(0.019)AS(0.001)R;SPDKPGGS(0.968)PS(0.025)AS(0.007)R;SPDKPGGS(0.982)PS(0.017)AS(0.001)R;S(0.001)PDKPGGS(0.865)PS(0.132)AS(0.002)R 140.77 0.0041015 173622600.0 6298.370000000001 6727.179999999999 7419.460000000001 7374.71 6142.48 5844.52 6094.29 6543.64 3348.5800000000004 5329.639999999999 True False 6445.10976650538 5939.558638218868 6411.93808417652 6086.855338951795 5586.89376854292 5785.729435199574 5634.592798758971 6370.0814104616875 5682.295689393322 6013.751209089838 1.0717287001769444 0.9876628466507181 1.0662127283358211 1.0121561613243093 0.929019770571533 0.9620832711626636 0.9369514306215785 1.05925256782044 0.9448837326034509 1.0 12.554049469029486 -6.008568259745114 23.839207199904134 0.9725470638943923 1.0369037259040506 0.3715276899559091 0.04099316282839443 248.76206023711302 692131.3756207755 0.011550872335976561 0.01622046264638714 9.804641988567754e-07 6.008568259745114 0.06435666200965828 SPDKPGGS(ph)PSASR ddPTM_A459_Selumetinib_30min_R2 1 SPDKPGGSPSASR 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 SPDKPGGS(0.475)PS(0.475)AS(0.049)R 112.57 0.02309 15247000.0 5732.0 5373.0 5925.4 5715.1 6199.7 5293.9 4674.1 5738.8 3229.9 5324.5 True False 5413.438387014043 5785.091823081996 5544.166215087724 4936.6935209026005 5420.838259978785 6023.086671760527 4891.454911553442 5755.498957890514 3875.9702509463027 5170.767850287598 1.0469312380196971 1.1188071076832873 1.0722133299369372 0.9547312244211509 1.0483623355237806 1.164834091599282 0.9459823092389227 1.1130839992304806 0.7495927806410263 1.0 12.336162818886383 -8.247610020001858 24.993863269468385 0.8747963722359515 1.0566589124313366 0.4236001293482393 0.08552422454872538 620.1605743210929 1120823.9769279703 0.05519694128260843 0.020621941285279867 5.654444946543801e-09 8.247610020001858 0.18186254019538506 SPDLPNAAS(ph)APPAAAPEAPR ddPTM_A459_Selumetinib_30min_R2 1 SPDLPNAASAPPAAAPEAPR 20 0 S4R3C3;S4R3I3;Q5JR12 S4R3C3 PPM1J Protein phosphatase 1J 1 SPDLPNAAS(1)APPAAAPEAPR 92.633 0.003812 0.0 9515.9 10078.0 8719.4 9099.5 8987.2 5038.8 4152.1 6279.4 6324.2 9889.2 True False 8987.044373165892 10850.95019412253 8158.4032969649115 7860.132402486957 7858.147589412599 5732.848962327762 4345.180877230067 6297.67201438937 7589.216712912038 9603.673100772674 0.9357924076406589 1.1298750051425122 0.8495086423035909 0.8184506407089764 0.8182439684229114 0.596943367623219 0.45244989408067954 0.6557565994080623 0.790241049781405 1.0 13.22937058119994 -5.837131917537047 1.2377447518895046 0.6747288906670403 1.0329510544156315 0.3808712929924728 0.14785247953816202 0.4482961212914298 1.374919157576043 0.05351322417935767 0.12507183842177932 1.455017050052184e-06 5.837131917537047 0.35822216374859117 SPDPRDPPAFAPQS(ph)ARITGMSHHAR ddPTM_A459_Selumetinib_30min_R1 1 SPDPRDPPAFAPQSARITGMSHHAR 25 2 J3QKQ5 J3QKQ5 KPNB1 1 SPDPRDPPAFAPQS(0.961)ARIT(0.029)GMS(0.01)HHAR 53.964 0.01672 25680000.0 4614.8 5132.2 5345.4 5499.7 5181.2 4600.1 4682.3 4455.1 2074.8 4360.3 True False 4722.315861162338 4531.319638104951 4619.5240401804385 4539.2806371549805 4712.561374815155 4553.827170556619 4329.110341258642 4336.936275795717 3520.784062603632 4919.986977918662 0.9598228374092269 0.9210023641204571 0.9389301355701289 0.9226204576409804 0.9578402129854304 0.925577077946466 0.8799028047610843 0.8814934460721688 0.7156084108362935 1.0 12.26443878174753 -7.423627563914755 2.0843282960124516 0.8494856057377635 0.9382034736126678 0.20223514822850353 0.06547461325811765 0.449073186357996 3.8192882259856082 0.03398521881791114 0.019142699497328955 3.7702698582753413e-08 7.423627563914755 0.08871786787490421 SPEEGAETPVYLALLPPDAEGPHGQFVSEK ddPTM_A459_Selumetinib_30min_R2 1 SPEEGAETPVYLALLPPDAEGPHGQFVSEK 30 0 P16152 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 97.057 1.1392000000000003e-07 2373600.0 4417.6 4554.5 4521.5 5058.3 5984.5 4050.0 3001.8 4790.4 3154.7 4706.5 False True 4172.087477053946 4903.815504974308 4230.591612636973 4369.350813945793 5232.673607891194 4607.850737760465 3141.3896479538557 4804.339270906589 3785.728149682743 4570.611116044429 0.9128073623258984 1.072901496204789 0.9256074308720185 0.9559664349057957 1.1448520723022564 1.0081476241952223 0.6873018876899173 1.0511371781426981 0.8282761437291231 1.0 12.158171359167108 SPEKIEEVLSPEGS(ph)PSKSPSK ddPTM_A459_Selumetinib_30min_R1 1 SPEKIEEVLSPEGSPSKSPSK 21 2 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 SPEKIEEVLS(0.003)PEGS(0.429)PS(0.109)KS(0.354)PS(0.105)K 59.154 0.0090985 39607000.0 2979.5 3114.3 7171.4 8053.5 4245.9 4180.9 3467.5 4002.6 2387.9 3068.7 True False 3048.916552902224 2749.6763082012094 6197.563269680475 6647.107407918177 3861.8590946745285 4138.843941953471 3205.943683299733 3896.4380457228613 4052.0918946844095 3462.597536669264 0.8805287130871792 0.7941079721457243 1.7898595502502508 1.919688135142657 1.1153069491262104 1.1953003195210208 0.9258782313995374 1.1252933684781963 1.1702462823855038 1.0 11.757638995155942 -6.483721198723118 24.99978143426895 1.089551385667669 1.3607197118361336 0.12593477944679254 0.3319667608112139 1273.0978198033997 812798.2116778692 0.11486012420859253 0.13021615111377588 3.2830598599099557e-07 6.483721198723118 0.27116832616846454 SPEKIEEVLSPEGSPSKS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 SPEKIEEVLSPEGSPSKSPSK 21 2 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 SPEKIEEVLS(0.001)PEGS(0.092)PS(0.092)KS(0.641)PS(0.173)K 66.77 0.003537 33315000.0 2096.6 2447.0 4843.8 5573.5 3598.9 3445.0 3015.5 3496.1 1939.3 2580.3 True False 2145.446700726564 2160.5041024205616 4186.038565088864 4600.192852552553 3273.3801304374006 3410.346427809731 2788.0384072070233 3403.372071066732 3290.850459132071 2911.5066392504 0.736885388411456 0.7420570756372403 1.4377568330624197 1.5800042460960775 1.1242908006145467 1.1713339004055174 0.9575930103064559 1.1689384544707644 1.130291243292283 1.0 11.507550193286342 -5.241118222197631 23.977028621135393 1.2040280565262516 0.7394709687225487 0.516210214878688 0.176763587565123 409.2139297189736 482829.9482657528 0.04913991373953636 0.12961153196588118 5.7396019940547026e-06 5.241118222197631 -0.46455708780370286 SPEPNKT(ph)SVLGGGEDGIEPVSPPEGMTEPGHSR ddPTM_A459_Selumetinib_30min_R2 1 SPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSR 33 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 S(0.219)PEPNKT(0.39)S(0.39)VLGGGEDGIEPVSPPEGMTEPGHSR 69.57600000000001 5.9691e-05 3717800.0 6410.5 8298.4 9544.3 10982.0 10276.0 6162.3 6147.6 6191.2 6101.6 8572.2 True False 6054.230073264745 8934.860596438413 8930.230129048126 9486.232654993315 8985.037011394417 7011.100889210201 6433.475581238298 6209.215366991666 7322.090492948377 8324.698312749615 0.7272611986421712 1.0732954229409504 1.0727391904846708 1.1395287010539183 1.0793228383584144 0.8422048014007203 0.7728178655297535 0.7458787254166316 0.8795622637440562 1.0 13.02318227449325 -6.790028365489951 10.018861820801844 0.8272660726125451 1.0312024475217347 0.31350705565524195 0.12341291797676056 0.4078002712109858 137.55367401073522 0.043664536219814754 0.03885997081668149 1.6217041739874966e-07 6.790028365489951 0.2039363749091896 SPESSESQTSQS(ph)ESR ddPTM_A459_Selumetinib_30min_R2 1 SPESSESQTSQSESR 15 0 A0A087WU78;A0A087WWC4;Q6T4R5-4;Q6T4R5-3;Q6T4R5-2;Q6T4R5 A0A087WU78 NHS Nance-Horan syndrome protein 1 SPESSES(0.001)QT(0.128)S(0.052)QS(0.646)ES(0.173)R 195.17 8.704100000000001e-21 0.0 3787.8 998.34 1067.4 976.62 3074.9 2020.9 2857.7 2156.3 1080.1 2123.9 True False 3577.2892397647893 1074.9094678309466 998.7246460972484 843.6026712365309 2688.6035720452214 2299.260631096328 2990.588712425125 2162.5744760053176 1296.150180515526 2062.5774884450802 1.7343781069101107 0.5211486471915734 0.4842119395233772 0.40900411061525715 1.3035163949510982 1.1147511518850506 1.4499279320068825 1.0484815664480185 0.6284128415910607 1.0 11.01023260527895 -6.276200895669044 24.945125169601585 1.1124215089792204 0.7465420459913136 0.1162593634964153 0.40134722004852275 1515.8428493531057 2561580.0397741683 0.12696479251245285 0.14457040726256942 5.29418489167863e-07 6.276200895669044 -0.36587946298790686 SPESSESQTSQSES(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SPESSESQTSQSESR 15 0 A0A087WU78;A0A087WWC4;Q6T4R5-4;Q6T4R5-3;Q6T4R5-2;Q6T4R5 A0A087WU78 NHS Nance-Horan syndrome protein 1 SPESSESQTSQS(0.017)ES(0.983)R 242.9 2.3675e-20 2870600.0 3500.8 2730.6 3052.4 3694.1 2427.1 3236.7 2464.8 2549.0 1032.5 2164.6 True False 3306.2395508127606 2940.0282397371475 2856.0119072018347 3190.957207322057 2122.1859994506985 3682.5260451627905 2579.4180839085443 2556.4171679903325 1239.028850460403 2102.1023736937805 1.5728251831061346 1.3986132533454958 1.3586454888889623 1.5179837325025034 1.0095540664471196 1.7518300208623594 1.2270658728081032 1.216124009934986 0.5894236484226034 1.0 11.0376172158194 -8.007767765851153 2.6976671528719547 0.801939744145039 1.4072324262429468 0.5592663016461565 0.2118264469594183 0.19627073727053376 2.726454053437948 0.15350276858939937 0.054036287913067284 9.822730622128431e-09 8.007767765851153 0.6052926820979078 SPFIYS(ph)PIIAHNR ddPTM_A459_Selumetinib_30min_R2 1 SPFIYSPIIAHNR 13 0 H0YBR0;Q96Q05-3;Q96Q05;Q96Q05-2 H0YBR0 TRAPPC9 Trafficking protein particle complex subunit 9 1 S(0.01)PFIY(0.072)S(0.918)PIIAHNR 75.018 0.031743 1892200.0 20158.0 21960.0 23153.0 20649.0 23683.0 20677.0 22026.0 13253.0 14978.0 20339.0 True False 19037.699058867598 23644.26138747079 21663.361187080365 17836.570578488172 20707.7298112937 23525.06906288225 23050.252643690998 13291.564035847734 17974.0185202866 19751.76022293161 0.9638482263856669 1.1970711025552052 1.0967812965818309 0.9030370142798756 1.0483992098715442 1.1910365859732268 1.1669973907910176 0.6729306090105505 0.9099957835362406 1.0 14.269693607610625 -7.748346932858276 24.999542568484348 0.8435973530470384 1.082224534894021 0.4225820497066801 0.11734190030805666 196.5822740226796 375368.1222491893 0.05601395748552493 0.03208827297973892 1.785061022651711e-08 7.748346932858276 0.2386271818469825 SPFNSPS(ph)PQDSPR ddPTM_A459_Selumetinib_30min_R1 2 SPFNSPSPQDSPR 13 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 S(0.001)PFNS(0.081)PS(0.788)PQDS(0.13)PR;S(0.048)PFNS(0.015)PS(0.85)PQDS(0.087)PR 102.15 0.0095328 36271000.0 3567.0 4321.4 2627.8 3004.7 3430.9 2865.2 3788.3 3610.6000000000004 1840.18 3340.8 True False 3650.104159826224 3815.448479035644 2270.959193472174 2479.985550204476 3120.5757007745915 2836.378689393452 3502.5454810221713 3514.835159118316 3122.651058570442 3769.6242221477096 0.9682939053661455 1.0121561869797797 0.602436492244926 0.657886676245816 0.8278214264541922 0.752430089113087 0.9291497705377719 0.9324099570635107 0.8283719741145285 1.0 11.88020499917339 -7.2721241949037765 23.699322591530173 0.9168504393333692 0.7983352322485021 0.18257893097625844 0.12280873334764715 725.1902671410741 1608489.0475769646 0.05569565561152254 0.038035595163680706 5.3441151223894347e-08 7.2721241949037765 -0.11851520708486707 SPFNSPS(ph)PQDSPR ddPTM_A459_Selumetinib_30min_R2 1 SPFNSPSPQDSPR 13 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 SPFNS(0.005)PS(0.992)PQDS(0.003)PR 115.26 0.004039 9980700.0 50028.0 43937.0 69214.0 94531.0 91413.0 72213.0 72805.0 88830.0 78963.0 77434.0 True False 47247.644037951555 47306.82662027796 64760.846594505245 81655.71472492944 79928.88169741129 82159.68526565352 76190.57676037058 89088.4805934019 94757.80641056148 75198.27922230611 0.6283075161637004 0.6290945365973921 0.8612011772643754 1.0858721179447928 1.0629083873198781 1.0925740072158785 1.013195747939005 1.1847143513754173 1.2601060475124997 1.0 16.19841202834266 -5.516210445011342 1.9512691468963512 1.1077223184493805 0.6104669264686102 0.8715792769658798 0.07287356810881478 0.1164108410841262 0.8633655677847789 0.022438261052547533 0.05991260957918656 3.04641843640614e-06 5.516210445011342 -0.4972553919807703 SPFNSPSPQDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SPFNSPSPQDSPR 13 0 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 SPFNS(0.039)PS(0.339)PQDS(0.621)PR;SPFNS(0.001)PS(0.395)PQDS(0.604)PR 139.0 0.00095779 48632000.0 84571.0 59379.0 93003.0 78199.0 85923.0 72793.0 81058.0 87134.0 74825.0 66243.0 True False 79870.88238453663 63933.17836642204 87019.28823401006 67548.16129920073 75128.58457863395 82819.57500093766 84827.3576133799 87387.54551418973 89792.09078518109 64330.392470016195 1.2415730624022496 0.9938254052502588 1.3526932588600162 1.0500194185926086 1.1678552188788633 1.2874097579855293 1.3186202408592045 1.3584177269697253 1.395795786991854 1.0 15.973212869925574 -6.760373775645032 5.0643853276534045 1.2984914844954443 1.1553586128905615 0.12791869006135648 0.13643837430801042 0.28976049038937374 20.744026884474245 0.04472944821532341 0.04194449930498325 1.7363058334955257e-07 6.760373775645032 -0.14313287160488275 SPFS(ph)VAVSPSLDLSK ddPTM_A459_Selumetinib_30min_R2 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 S(0.017)PFS(0.923)VAVS(0.057)PS(0.003)LDLSK 97.073 0.0097628 2277000.0 9009.1 10780.0 11189.0 10160.0 10938.0 8045.0 8269.8 9024.8 6874.3 11163.0 True False 8508.410288284751 11606.791336836754 10469.11192166208 8776.190473022418 9563.870653039325 9153.125724761214 8654.362086297819 9051.060673863933 8249.352083990269 10840.695185042816 0.7848583640672807 1.0706685446567061 0.9657232993790454 0.8095597490031038 0.8822193124878966 0.8443301438260173 0.7983216886531838 0.8349151525219446 0.760961538275895 1.0 13.404169655416062 -5.7559361273195675 24.844818965902554 0.8396128743018174 0.9534419462685438 0.1805859317615992 0.08870805292025113 167.19144465715863 754786.2971779762 0.02297465182098643 0.03838005132397127 1.7541384680185672e-06 5.7559361273195675 0.11382907196672643 SPFSVAVSPS(ph)LDLSK ddPTM_A459_Selumetinib_30min_R1 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 S(0.234)PFSVAVS(0.041)PS(0.725)LDLSK 183.58 2.0915e-05 40409000.0 2838.1 2898.4 3654.3 3652.0 3229.3 2780.4 2998.5 2433.3 1916.3 2426.9 True False 2904.222208018728 2559.053980570395 3158.066131633065 3014.2467565303523 2937.2103851792235 2752.4317004012128 2772.3207308938 2368.760979527667 3251.8211389856065 2738.416255007867 1.0605481189018082 0.9345014571435354 1.1532454665567242 1.1007262869616923 1.0725945625716369 1.0051180843554062 1.0123810526701083 0.8650112908130039 1.187482411791433 1.0 11.419126045863944 -6.766583495738336 23.698033913257444 1.0054606577273482 1.0640733852258413 0.0701366351068915 0.088940874307636 173.62493869664067 799850.8015181944 0.03037016457994942 0.027635716529067385 1.7116560688456022e-07 6.766583495738336 0.05861272749849311 SPFSVAVSPS(ph)LDLSK ddPTM_A459_Selumetinib_30min_R2 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 S(0.041)PFS(0.236)VAVS(0.128)PS(0.595)LDLSK 164.8 9.1467e-05 10027000.0 66080.0 62413.0 69328.0 77589.0 67861.0 46892.0 50925.0 49927.0 43205.0 55253.0 True False 62407.53813919877 67199.87641057455 64867.511958619114 67021.24435150948 59335.69449496269 53350.94735680583 53293.11340597311 50072.279304140226 51847.207248563405 53657.70232546542 1.163067657289171 1.2523808045854798 1.208913336712773 1.249051700816154 1.105818772020034 0.9942831139731079 0.9932052826772033 0.9331797138912602 0.9662584307855693 1.0 15.71149765787826 -6.592069120819777 2.2855228671532717 0.9697896601670198 1.220649640173312 0.9357368855945849 0.02975978949830615 0.0656058471063342 0.6959716176297034 0.010646439269922866 0.010944350003694774 2.558178703557608e-07 6.592069120819777 0.25085998000629217 SPGAGSLGS(ph)PASQR ddPTM_A459_Selumetinib_30min_R1 2 SPGAGSLGSPASQR 14 0 E9PC47;P53667-4;P53667-2;P53667 E9PC47 LIMK1 LIM domain kinase 1 1 SPGAGSLGS(1)PASQR;SPGAGSLGS(0.999)PAS(0.001)QR 207.08 7.0703e-06 26164000.0 2362.5 2436.7 2359.4 2777.2 2804.3 2416.5 2618.5 2405.4 1212.19 2273.3999999999996 True False 2417.5416533752314 2151.4100312089017 2039.0064392565075 2292.214154500574 2550.6515601393767 2392.1922040064487 2420.9844368335557 2341.600978159641 2056.997895145314 2565.213034791249 0.942433092529473 0.8386866907465167 0.7948682669244417 0.8935765269441291 0.9943234832918829 0.932551087009863 0.9437751968348975 0.9128290502196809 0.8018818972330334 1.0 11.32486292783337 -5.998226827369927 24.998271172060686 0.9287789786380073 0.8545912936286171 0.21900276326813117 0.06123796107586607 89.13725228667586 1256608.0439763044 0.017513413759310526 0.025769102741046452 1.004091227178526e-06 5.998226827369927 -0.07418768500939021 SPGAGSLGS(ph)PASQR ddPTM_A459_Selumetinib_30min_R2 2 SPGAGSLGSPASQR 14 0 E9PC47;P53667-4;P53667-2;P53667 E9PC47 LIMK1 LIM domain kinase 1 1 SPGAGSLGS(1)PASQR;SPGAGSLGS(1)PASQR 201.16 6.1899e-05 57101000.0 61174.0 53260.0 72160.0 62147.0 73643.0 67895.0 73730.0 66711.0 59042.0 63494.0 True False 57774.193978924806 57344.87074210816 67517.30416186765 53682.471390445244 64391.307963226864 77246.91996055472 77158.5910932233 66905.11796539943 70852.04977131542 61660.76324277595 0.9369685183988298 0.930005853419704 1.0949800263748413 0.8706099076179465 1.0442833428723544 1.252772685547398 1.25134018840195 1.085051732200832 1.1490621595511357 1.0 15.912065126921117 -6.543868140116924 7.801631494023212 1.158692693164421 0.9647381973909855 0.5109156853198611 0.08714748954197019 0.1410515894738811 39.15122301100078 0.028316054158131158 0.02870525342404163 2.8584582927441003e-07 6.543868140116924 -0.1939544957734355 SPGDPAKPAS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 2 SPGDPAKPASSPR 13 1 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3;H7C3V8 C9JWC4 HJURP Holliday junction recognition protein 1 SPGDPAKPAS(0.5)S(0.5)PR;SPGDPAKPAS(0.5)S(0.5)PR 144.4 0.0031859 34107000.0 6648.5 7699.9 6793.1 6479.299999999999 7127.1 6015.9 6238.4 6843.700000000001 3193.2 5935.4 True False 6803.397114271 6798.392128413608 5870.634331827318 5347.811886524398 6482.455063391708 5955.385508000163 5767.8324654353455 6662.182844529448 5418.627177899516 6697.266405691907 1.0158468697749419 1.0150995520554111 0.8765717198942473 0.7985066686281693 0.9679255192659451 0.8892263122367016 0.8612218950306876 0.9947615102883407 0.8090804291873929 1.0 12.709356641770874 -5.255171359508554 23.95338181467454 0.8965544301071183 1.0154732435205738 0.32501706997858704 0.06663797140473982 301.91094630382275 1153742.7796356906 0.016222525245969656 0.04060142748863806 5.556849574784196e-06 5.255171359508554 0.11891881341345545 SPGDPAKPAS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 SPGDPAKPASSPR 13 1 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3;H7C3V8 C9JWC4 HJURP Holliday junction recognition protein 1 SPGDPAKPAS(0.5)S(0.5)PR 62.528 0.047027 43934000.0 67705.0 70134.0 64003.0 68394.0 72833.0 55962.0 63709.0 63522.0 53007.0 63689.0 True False 63942.22714458927 75513.05228364648 59885.116661197484 59078.619213769125 63683.06740471879 63670.25752754352 66671.5947369886 63706.83850336683 63609.881139326455 61850.13308610509 1.0338252151466134 1.2209036345729518 0.9682293905144554 0.9551898478782967 1.0296350909392866 1.02942797938534 1.077953941411432 1.0300194247711143 1.0284518070603264 1.0 15.916489079075383 -5.276370031218316 24.997935476313533 1.017105311834487 1.1273644389134732 0.41643595071096884 0.05321754035528263 672.3893369155825 1125761.0562400308 0.01385544219541181 0.029041985014380146 5.292123478129911e-06 5.276370031218316 0.11025912707898611 SPGGGGGGGSGNDNNQAATKS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SPGGGGGGGSGNDNNQAATKSPR 23 1 Q9NS37;E9PIM0;J3KN20 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 SPGGGGGGGSGNDNNQAAT(0.102)KS(0.898)PR;SPGGGGGGGSGNDNNQAAT(0.1)KS(0.9)PR 118.61 5.8812e-06 6747800.0 930.86 874.81 1162.8400000000001 1218.08 1107.95 744.78 895.1199999999999 952.38 624.97 944.54 True False 952.5472268617431 772.386838511865 1004.9327150229027 1005.3651941934536 1007.7361181244595 737.2881894061344 827.6003777347538 927.1197886337732 1060.5284439972004 1065.7809095987186 0.8937551970417544 0.7247144620020257 0.9429074080537565 0.9433131942398815 0.9455377827173562 0.6917821315487193 0.7765201743446098 0.8698971620563618 0.9950717210692994 1.0 10.05769518136965 -8.229811883106859 4.206652496937191 1.0013382779917128 0.8450929676807069 0.32534337767116983 0.08630859217292759 0.2593765235804031 10.349319033995894 0.07526223623289745 0.023858900336885484 5.890987712681378e-09 8.229811883106859 -0.15624531031100597 SPGGGGGGGSGNDNNQAATKS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SPGGGGGGGSGNDNNQAATKSPR 23 1 Q9NS37;E9PIM0;J3KN20 Q9NS37 CREBZF CREB/ATF bZIP transcription factor 1 SPGGGGGGGSGNDNNQAAT(0.262)KS(0.738)PR;SPGGGGGGGSGNDNNQAAT(0.038)KS(0.962)PR 72.058 0.00099025 2934600.0 3509.55 3190.1499999999996 3114.3 2830.2 3886.97 3677.1099999999997 2300.5 1047.6 1254.3 4901.299999999999 True False 3314.5032608417864 3434.8242470509977 2913.929328593461 2444.721877632679 3398.6540786473092 4183.5985250188605 2407.477808354269 1050.6483425604836 1505.1950480702017 4759.7867338932465 0.696355413833994 0.7216340645248822 0.6121974557902147 0.5136200452479159 0.7140349491808838 0.878946633307855 0.5057953103678415 0.22073433145209648 0.3162316154528701 1.0 12.216681218521487 -7.507118930920794 24.56853168361334 0.43374275158834463 0.6815247743333536 0.11284255082169337 0.21323414491739223 832.6485908296329 1298052.3978000656 0.08845912248543479 0.05758365972136708 3.110864314719309e-08 7.507118930920794 0.24778202274500893 SPGKAEAES(ph)DALPDDTVIESEALPSDIAAEAR ddPTM_A459_Selumetinib_30min_R1 1 SPGKAEAESDALPDDTVIESEALPSDIAAEAR 32 1 G3V529;Q9GZR7-2;Q9GZR7;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 1 S(0.201)PGKAEAES(0.788)DALPDDT(0.011)VIESEALPSDIAAEAR 90.435 8.2093e-08 4864400.0 351.05 615.49 1001.3 1264.0 569.9 530.2 699.17 535.5 321.3 364.55 True False 359.22878197560834 543.428144666462 865.3289597471982 1043.26612821861 518.3526456240171 524.866669383083 646.4310439950036 521.2968004508556 545.2226331764731 411.3435435177049 0.8733059935828227 1.3211053223765306 2.1036648645244944 2.536240436149464 1.2601453305701547 1.275981299948353 1.5715113417531499 1.2673027416277365 1.325467827971404 1.0 8.684199988799927 SPGLVPPS(ph)PEFAPR ddPTM_A459_Selumetinib_30min_R2 1 SPGLVPPSPEFAPR 14 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 S(0.094)PGLVPPS(0.906)PEFAPR 104.16 0.006381 8491900.0 25433.0 23378.0 27446.0 28395.0 34076.0 23654.0 28395.0 35691.0 26950.0 20094.0 True False 24019.535676365675 25171.01742788216 25680.15424094534 24527.552015892852 29795.068236694842 26912.123790366924 29715.423763625073 35794.85490103688 32340.753045915615 19513.83400951808 1.2308978166284439 1.2899063000948316 1.3159973702973784 1.256931467385101 1.5268690008412484 1.3791305069644566 1.5227875644084632 1.8343322426324606 1.6573243899759047 1.0 14.252209640997005 -6.461665069211057 1.2185209808980173 1.5549104066848194 1.2653005597580846 0.15891251211322632 0.20806223077660835 0.6587190063137381 2.036275575469691 0.08961816086087196 0.10732610465021132 3.454100191451902e-07 6.461665069211057 -0.28960984692673475 SPGS(ph)NSKVPEIEVTVEGPNNNNPQTSAVR ddPTM_A459_Selumetinib_30min_R2 1 SPGSNSKVPEIEVTVEGPNNNNPQTSAVR 29 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 S(0.083)PGS(0.458)NS(0.458)KVPEIEVT(0.001)VEGPNNNNPQTSAVR 103.59 1.0337e-08 14791000.0 26117.0 50367.0 35973.0 54814.0 39669.0 13941.0 9193.9 8965.5 3011.5 44180.0 True False 24665.521694634623 54229.986944569275 33658.53634444099 47348.23864057583 34685.42557464045 15861.246206202133 9621.434567367232 8991.58812068157 3613.884148340439 42904.408606574514 0.5748948067508142 1.263972368011134 0.7845006477791953 1.1035751378081076 0.8084350000648974 0.36968802790516997 0.22425281876261263 0.20957259201805503 0.08423106775527633 1.0 15.38883827781177 -6.718940694180565 3.483986916786002 0.31051111104900303 0.9461804748185905 0.45290971592791307 0.2890662878640976 0.1823509322228825 4.562934639006221 0.09584196023441018 0.09174954561741083 1.9101140796246362e-07 6.718940694180565 0.6356693637695874 SPGS(ph)PPGPELPIETALDDR ddPTM_A459_Selumetinib_30min_R1 3 SPGSPPGPELPIETALDDR 19 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.015)PGS(0.985)PPGPELPIETALDDR;SPGS(1)PPGPELPIETALDDR;S(0.411)PGS(0.589)PPGPELPIETALDDR 161.2 1.4769999999999996e-06 79907200.0 5206.12 7370.84 5836.88 6253.969999999999 5732.59 5663.66 6502.01 6160.049999999999 3353.84 5220.92 True False 5327.412466653911 6507.858626189448 5044.263755686831 5161.831541056445 5214.078246670969 5606.688722591831 6011.558150901717 5996.665463337607 5691.221525218125 5891.075938067359 0.9043190959785243 1.1046977996220555 0.8562550896842903 0.8762120188778024 0.8850808072220356 0.9517257596973322 1.0204516482389605 1.0179236401601859 0.9660750574342793 1.0 12.52431543463548 -7.092226923486854 4.886788302896379 1.0019219635745928 0.9277994328675445 0.2268232438815142 0.06587117100170164 0.38339839158088207 15.098114570428134 0.02696908954561148 0.02090445705898792 8.086732483932156e-08 7.092226923486854 -0.07412253070704833 SPGS(ph)PPGPELPIETALDDR ddPTM_A459_Selumetinib_30min_R2 3 SPGSPPGPELPIETALDDR 19 0 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.005)PGS(0.995)PPGPELPIETALDDR;S(0.02)PGS(0.98)PPGPELPIETALDDR;S(0.061)PGS(0.939)PPGPELPIETALDDR 193.27 3.1563000000000004e-15 31234000.0 46329.0 43735.0 51899.0 52085.0 62087.0 45753.0 43728.0 44184.0 44846.0 51119.0 True False 43754.21964968133 47089.333869810325 48559.87484335867 44990.93314836343 54287.07599517758 52055.060445618416 45761.438645388196 44312.56812494501 53816.45310193438 49643.061646887356 0.8813763333314624 0.9485582135275665 0.9781804995986464 0.9062884450678191 1.0935481050972087 1.048586826007785 0.921809355170129 0.8926235944136905 1.0840679707616039 1.0 15.599304473393476 -4.142045788841834 0.852482044961638 0.9919978554268405 0.6545266334919643 0.21767026156051017 0.066070004718494 10.722539738283475 2.787030938152086 0.024219714442618865 4.398859908021284 7.210314548788331e-05 4.142045788841834 -0.3374712219348762 SPGS(ph)PPGPELPIETALDDRER ddPTM_A459_Selumetinib_30min_R1 2 SPGSPPGPELPIETALDDRER 21 1 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.471)PGS(0.527)PPGPELPIET(0.002)ALDDRER;S(0.447)PGS(0.553)PPGPELPIETALDDRER 79.455 0.0012032 32848900.0 978.27 974.96 1314.4099999999999 1615.8899999999999 1210.42 953.5699999999999 1266.4099999999999 936.72 705.8 689.0699999999999 True False 1001.0617876179423 860.811229953393 1135.9203415373165 1333.7051455120013 1100.9377247170075 943.9779515722863 1170.8836741074588 911.8751427046219 1197.691050407578 777.51884661019 1.2875080674665957 1.1071258705899403 1.4609553793964964 1.7153348132031272 1.4159627506353731 1.2140901223009848 1.5059232058647225 1.1728013368167158 1.540401310693941 1.0 9.602733835540823 -10.664519829469262 5.237165354864596 0.9999879179554823 1.3780147661681132 0.2917707563332379 0.17759224771353943 2.5902878509260923e-05 4.245209723286807e-06 0.1777853475697052 0.04311790311254456 2.1651110201596635e-11 10.664519829469262 0.378026848212631 SPGS(ph)PPGPELPIETALDDRER ddPTM_A459_Selumetinib_30min_R2 1 SPGSPPGPELPIETALDDRER 21 1 F5GZI3;B1AP52;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.177)PGS(0.823)PPGPELPIET(0.001)ALDDRER 60.17100000000001 0.011393 2980700.0 6808.4 5146.4 8056.3 6661.2 6814.1 3396.7 3645.4 3228.7 3708.1 6634.9 True False 6430.0163841846415 5541.11233171583 7537.966429036217 5753.933068789062 5958.051839173094 3864.5645928273984 3814.9183232230625 3238.0949824599415 4449.823612970671 6443.333197459512 0.9979332415588688 0.8599760654781269 1.169886175063599 0.8930056684105259 0.9246847332871508 0.5997772386427456 0.5920721785313252 0.5025496716104427 0.6906089560485797 1.0 12.653591485954603 -6.692297885117541 4.697144466953596 0.6403237053794177 0.9759166189256597 0.4923507434458484 0.14640695870943968 0.15612804676206865 6.575473531070046 0.047706523660262665 0.04687750601362427 2.0309634833805672e-07 6.692297885117541 0.335592913546242 SPGS(ph)PVGEGTGSPPK ddPTM_A459_Selumetinib_30min_R1 3 SPGSPVGEGTGSPPK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.006)PGS(0.53)PVGEGT(0.453)GS(0.011)PPK;SPGS(1)PVGEGTGSPPK;SPGS(0.932)PVGEGT(0.065)GS(0.003)PPK 200.0 2.0304e-05 275066000.0 10291.6 13592.9 9549.3 10275.9 11569.5 10585.400000000001 11642.4 11268.9 6755.5 11018.3 True False 10531.374256032397 12001.436948832234 8252.557510550203 8481.406967532925 10523.040767761126 10478.920486774208 10764.204394649989 10970.012165454045 11463.590097801627 12432.606132330624 0.8470769639075005 0.9653194849970235 0.6637833952681628 0.6821905944142538 0.8464066709550357 0.8428579153267058 0.8658043438421165 0.8823582158632737 0.9220584948791147 1.0 13.601841126470017 -8.087863053249372 0.7675124610462624 0.9938695391750936 0.7994456802660573 0.37887625558764804 0.08082110227638194 0.732496004159668 0.8927115037346158 0.08390278338955835 0.034765771078801216 8.168399061429098e-09 8.087863053249372 -0.19442385890903624 SPGS(ph)PVGEGTGSPPK ddPTM_A459_Selumetinib_30min_R2 6 SPGSPVGEGTGSPPK 15 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 SPGS(1)PVGEGTGSPPK;SPGS(1)PVGEGTGSPPK;S(0.007)PGS(0.992)PVGEGTGSPPK;SPGS(1)PVGEGTGSPPK;SPGS(1)PVGEGTGSPPK;SPGS(1)PVGEGTGSPPK 260.29 2.2043e-36 615323000.0 923691.0 754658.2 930794.0 919981.0 1007676.0 720583.0 853767.0 846840.0 688082.4 813259.0 True False 872355.9520480434 812538.057331431 870907.7274118798 794678.0007442567 881082.7321422615 819836.7674488025 893468.8572072153 849304.164198092 825718.1066286067 789778.0995693561 1.1045582962147402 1.0288181677543164 1.1027245854079284 1.006204149213016 1.1156079569979103 1.038059637125715 1.1312910014780087 1.075370619495772 1.045506461978178 1.0 19.591087837068258 -8.577064739845765 2.986842473987143 1.0001909046032802 1.074147277718143 0.26968440603388044 0.03835909237552926 0.3796805023902289 8.606879779155147 0.03425216874810617 0.009130146237461086 2.648105358754974e-09 8.577064739845765 0.0739563731148627 SPGS(ph)TPTTPT(ph)SSQAPQK ddPTM_A459_Selumetinib_30min_R2 1 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 2 S(0.003)PGS(0.917)T(0.08)PT(0.001)T(0.105)PT(0.736)S(0.133)S(0.025)QAPQK 215.49 4.7062e-08 56716000.0 104290.0 82912.0 96191.0 103710.0 107370.0 77859.0 84604.0 84948.0 89577.0 109520.0 True False 98493.97930594794 89271.08379590085 90002.175784842 89584.519090271 93881.2207000213 88583.3705163683 88538.25363964548 85195.1846161015 107494.90299050025 106357.87303286622 0.9260619500684428 0.8393462679374446 0.8462201548260554 0.8422932551743302 0.8826917840958568 0.8328802371686643 0.832456038419326 0.8010237717876784 1.010690604514841 1.0 16.69856730571439 -8.271314308533116 24.98981513390227 1.0053453413593127 0.8494936038721366 0.7917907822001324 0.03178539730543953 321.0306668032693 812401.1219121119 0.029074557510300292 0.007874117733741635 5.354090298924442e-09 8.271314308533116 -0.15585173748717618 SPGS(ph)TPTTPTS(ph)SQAPQK ddPTM_A459_Selumetinib_30min_R2 1 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 2 SPGS(0.712)T(0.287)PT(0.001)T(0.02)PT(0.382)S(0.509)S(0.088)QAPQK 122.14 0.025486 4566400.0 18920.0 16076.0 17301.0 20857.0 21437.0 13933.0 15012.0 18021.0 18263.0 22133.0 True False 17868.50214276093 17308.977507512776 16187.87249590452 18016.240619668162 18743.89241078844 15852.144278818896 15710.087745713681 18073.438126462857 21916.110310855518 21493.962781559854 0.8313265601302108 0.8052948487638831 0.7531357833089974 0.8382000472767495 0.8720538228003838 0.7375161313863817 0.7309069949256501 0.8408611436681401 1.0196402838129892 1.0 14.391643872471063 -8.189554997290939 4.031203089752779 1.0120422957903283 0.7961768843754882 0.7883881637058899 0.04365219812784279 0.10107694699369238 3.05497632331469 0.036555098045819155 0.012067965818501098 6.463161419632961e-09 8.189554997290939 -0.21586541141484017 SPGS(ph)TPTTPTSSQAPQK ddPTM_A459_Selumetinib_30min_R1 1 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 S(0.136)PGS(0.8)T(0.064)PTTPTSSQAPQK 246.34 2.5212e-30 66350000.0 6953.2 8302.1 7105.1 6907.3 7432.7 7049.4 7632.6 7066.4 3630.6 7168.2 True False 7115.196031428006 7330.086272458422 6140.26644552064 5701.069721079436 6760.413597349767 6978.48943634308 7056.86683695849 6878.976117097893 6160.863031467485 8088.3082941808025 0.8796890242854727 0.9062570324788572 0.7591533633724501 0.7048531675259109 0.8358254101433794 0.8627872705302059 0.8724774798749461 0.8504839166488036 0.7616998273792267 1.0 12.98162227275479 -6.520767067977308 23.3290206187546 0.8591066709445797 0.8097466850067376 0.10475833891717878 0.07574576739249625 99.4274873883398 1098479.9551135264 0.025750344982761915 0.026200105920263388 3.0146224707704215e-07 6.520767067977308 -0.04935998593784208 SPGSPVGEGT(ph)GSPPKWQIGEQEFEALMR ddPTM_A459_Selumetinib_30min_R1 2 SPGSPVGEGTGSPPKWQIGEQEFEALMR 28 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.007)PGS(0.057)PVGEGT(0.468)GS(0.468)PPKWQIGEQEFEALMR;SPGS(0.001)PVGEGT(0.794)GS(0.204)PPKWQIGEQEFEALMR 75.43 0.00014038 38758000.0 1479.46 1157.7 2213.7 2237.6 2098.45 1517.46 1358.5 1405.9 790.56 946.1299999999999 True False 1513.928539471966 1022.155945799871 1913.091698983694 1846.8451649540857 1908.6455680114377 1502.1957301434416 1256.0272512653746 1368.610964993197 1341.5225797821117 1067.5750015866302 1.41810040252157 0.9574558642537926 1.7919974672884404 1.7299441839770546 1.787832766011576 1.4071102525919752 1.1765236628795792 1.281981090751626 1.2566073369911628 1.0 10.060121713398809 -7.096003757571216 4.358544819891995 1.2051303598283538 1.5352338600030433 0.33072061127761654 0.2384983196360622 0.3313091516299258 10.813631336327362 0.10234994414879474 0.07918801513259684 8.016711271968929e-08 7.096003757571216 0.3301035001746895 SPGST(ph)PTTPT(ph)SSQAPQK ddPTM_A459_Selumetinib_30min_R1 1 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 2 S(0.155)PGS(0.339)T(0.507)PT(0.001)T(0.101)PT(0.719)S(0.149)S(0.031)QAPQK 152.68 0.0013113 9989700.0 1237.5 1848.4 1289.3 1333.7 1412.9 1158.5 1322.1 1588.8 912.31 1253.6 True False 1266.3313422441686 1631.9884687021522 1114.2201416179596 1100.7943316496526 1285.103444467756 1146.8465418338383 1222.3729325711827 1546.6598628502688 1548.1234375139372 1414.5117710980521 0.8952427036087126 1.1537468277377982 0.7877065178135751 0.7782150379668682 0.9085137859758922 0.8107720029389139 0.8641659670476148 1.093423112095867 1.094457797485959 1.0 10.466088467076087 -7.7612117382086145 24.999999791223562 1.0704553780820019 0.8859247073098996 0.38322585540546117 0.10284111447382042 6.57204330572514 722044.5120922147 0.05503110446199602 0.029196919206575935 1.732958895892568e-08 7.7612117382086145 -0.18453067077210228 SPGSTPT(ph)TPTSSQAPQK ddPTM_A459_Selumetinib_30min_R2 3 SPGSTPTTPTSSQAPQK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SPGS(0.002)T(0.037)PT(0.91)T(0.052)PTSSQAPQK;SPGS(0.007)T(0.027)PT(0.593)T(0.368)PT(0.004)S(0.001)SQAPQK;SPGSTPT(0.632)T(0.368)PTSSQAPQK 242.9 1.8087999999999998e-22 18088200.0 65247.0 59313.0 72391.0 73315.0 78130.0 50043.0 65123.0 77107.0 70216.0 71199.0 True False 61620.8329444356 63862.11637864548 67733.4418733614 63329.370524570615 68314.61090893792 56935.96900487582 68151.34853877654 77331.36860424894 84261.16199896157 69143.29987278178 0.891204687335043 0.9236197360575318 0.9796096223059299 0.9159147833715149 0.9880149057772976 0.8234488245373524 0.9856536882701528 1.118421723385094 1.218645366275481 1.0 16.07730183759716 -7.674625804293787 3.7976430501167298 1.1282220445292506 0.9247507336929657 0.6247302966355898 0.06600347632315443 0.1337168737410624 3.6891766140213007 0.03304588430249595 0.017439796010735944 2.1153108436205605e-08 7.674625804293787 -0.2034713108362849 SPHQLLSPSSFS(ph)PSATPSQK ddPTM_A459_Selumetinib_30min_R2 1 SPHQLLSPSSFSPSATPSQK 20 0 E9PIQ6;A0A3B3ITS5;Q14181 E9PIQ6 POLA2 DNA polymerase alpha subunit B 1 SPHQLLSPSSFS(0.997)PS(0.002)AT(0.001)PSQK 173.45 4.8917e-10 9676500.0 28466.0 24143.0 47578.0 55914.0 58457.0 40866.0 33351.0 31808.0 35159.0 47218.0 True False 26883.97367842666 25994.690468019464 44516.883279009635 48298.41674297002 51113.109047789374 46494.92055538745 34901.887583752796 31900.556013902144 42191.78242453976 45854.693652902584 0.5862861909388182 0.56689268637986 0.9708250068352977 1.053292757957674 1.1146756193529588 1.013962080028951 0.7611410044071578 0.6956879104977479 0.9201191647666592 1.0 15.484781794137303 -5.259052148307029 24.70471737143293 0.9367096481157037 0.576589392828906 0.5931774758803072 0.12073943351004011 136.64879628452408 1414108.9507643457 0.036454490868999885 0.08749844294637828 5.507415616382799e-06 5.259052148307029 -0.3601202552867977 SPIIHS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SPIIHSPK 8 0 O94913;E9PKN0;E9PQ01 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 S(0.008)PIIHS(0.992)PK;SPIIHS(1)PK 89.266 0.029909 34572000.0 6715.0 7576.6 8019.4 8899.7 7331.200000000001 6431.8 7389.2 6651.8 2958.5 5568.5 True False 6871.446434884521 6689.5281497342185 6930.409527411044 7345.534463059471 6668.094254428489 6367.10193160715 6831.8266949209465 6475.372655908498 5020.358419709292 6283.271216783269 1.093609713445152 1.0646569149945009 1.1029938527719767 1.1690621349335975 1.0612456512488777 1.0133418902243088 1.087304122201892 1.0305734755826084 0.7990039338584326 1.0 12.617300139879521 -8.064257235379223 5.8024480499405025 0.9005173498988488 1.082708468338109 0.6114214137848654 0.058219159003043884 0.14292020851042328 9.392534879559435 0.039287487473172254 0.014689849790415661 8.624675514416911e-09 8.064257235379223 0.18219111843926017 SPIS(ph)PELHSAPLTPVAR ddPTM_A459_Selumetinib_30min_R2 1 SPISPELHSAPLTPVAR 17 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 S(0.068)PIS(0.932)PELHSAPLTPVAR 97.621 0.0036499 7234100.0 14842.0 18111.0 18518.0 19599.0 16376.0 14610.0 12077.0 12256.0 11789.0 18112.0 True False 14017.141057233495 19500.05546395644 17326.572040873933 16929.582389839194 14318.700476702508 16622.394883624795 12638.604430121512 12291.662930909975 14147.129412181775 17589.059499372514 0.79692385245121 1.1086468531561964 0.9850766632230709 0.9625064029400294 0.8140685678625014 0.945041710969128 0.7185491885209889 0.6988243419921616 0.8043141483878926 1.0 14.102390722401015 -6.507027436355384 1.3353798272403634 0.7946263951034412 0.9790305826541778 0.22028398326522391 0.11325712662329535 0.5157029132348953 1.9001238769223392 0.04727092708463654 0.0535755721731546 3.111519762058082e-07 6.507027436355384 0.1844041875507365 SPITS(ph)SPPK ddPTM_A459_Selumetinib_30min_R2 1 SPITSSPPK 9 0 G3V5T8;Q52LA3 G3V5T8;Q52LA3 LIN52 Protein lin-52 homolog 1 SPIT(0.022)S(0.676)S(0.301)PPK 82.029 0.042377 25714000.0 150400.0 125600.0 126490.0 130590.0 115360.0 96767.0 145060.0 146990.0 98536.0 114220.0 True False 142041.370098903 135233.11613234645 118351.77111189911 112803.41671968481 100867.44546851491 110095.77588663393 151805.57743093683 147417.71656449535 118245.95332587506 110922.17182079988 1.2805498465029848 1.2191711892444919 1.066980290496855 1.0169600438578157 0.9093533223589522 0.9925497678182769 1.3685773992614034 1.3290193848949856 1.0660263082200292 1.0 16.759188243712842 -7.243579138597987 24.79661970109074 1.2183240793169798 1.0758708326046909 0.11140137533138805 0.1436447169315854 1377.6101566263103 1912634.8329827078 0.05864705760593566 0.04532772483712418 5.7071706871627054e-08 7.243579138597987 -0.14245324671228898 SPITSS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 2 SPITSSPPK 9 0 G3V5T8;Q52LA3 G3V5T8;Q52LA3 LIN52 Protein lin-52 homolog 1 SPIT(0.006)S(0.207)S(0.787)PPK;SPIT(0.008)S(0.188)S(0.803)PPK 95.483 0.022335 39979000.0 357410.0 292110.0 301340.0 275650.0 272360.0 231397.0 317060.0 307130.0 234240.0 265900.0 True False 337546.58302559087 314513.8977183108 281952.11247418507 238105.99447722727 238143.701870707 263269.83633717505 331803.91824247094 308023.6974518912 281094.5452124407 258222.77610883137 1.3071913644183248 1.2179944095471842 1.0918948232333798 0.9220952468455934 0.9222412734434325 1.0195453720403678 1.2849521767306376 1.192860297195746 1.0885737867443952 1.0 17.978256731201526 -5.132388197522808 2.831185637973334 1.067373603207786 1.2955876091117042 0.3690142712477731 0.10638739926850664 0.3588429925948751 5.295763073048352 0.03278226309035623 0.12662918760364167 7.372449433540535e-06 5.132388197522808 0.22821400590391816 SPIYPLS(ph)DSETSACR ddPTM_A459_Selumetinib_30min_R2 3 SPIYPLSDSETSACR 15 0 E9PRS6;E9PI72;E9PLB6;E9PII1;E9PK36;E9PN93;E9PQU6;E9PME1;E9PMP1;E9PLH6;E9PMJ9;E9PJY5;E9PLR2;E9PM84;P78524 E9PRS6 ST5 Suppression of tumorigenicity 5 protein 1 SPIYPLS(0.938)DS(0.057)ET(0.001)S(0.004)ACR;SPIYPLS(0.907)DS(0.065)ET(0.002)S(0.026)ACR;SPIYPLS(0.991)DS(0.003)ETS(0.005)ACR 116.58 0.0027733 0.0 29668.899999999998 21285.3 30220.9 31003.5 34376.0 25741.1 25177.5 26758.800000000003 24163.4 22917.0 True False 28020.02131201688 22917.814066973224 28276.520196028054 26780.769815979373 30057.379554660794 29286.702870559497 26348.303638269786 26836.663677842203 28996.755181806202 22255.32666448322 1.259025389042409 1.029767588338627 1.2705506696135773 1.2033420232253076 1.3505701357611928 1.3159412715921845 1.1839099931217123 1.2058535056540076 1.3029130337629005 1.0 14.441863056424612 -4.390110147437785 22.881749226085628 1.217867808350778 46.17459691853023 0.011151785799435099 0.11026923230859992 10186.195985542978 1762217.77387949 0.026018088542516093 91934.26143059539 4.0727696955161706e-05 4.390110147437785 44.95672911017945 SPLAQMEEERR ddPTM_A459_Selumetinib_30min_R1 2 SPLAQMEEERR 11 1 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;A0A0U1RRM2 E7EPK1 SEPT7 Septin-7 0 ; 136.5 0.007008400000000001 48831000.0 3704.9 4157.3 4354.6 4743.1 4293.6 3851.3999999999996 4253.1 4030.6 2090.37 2948.3 False True 3791.2169615195326 3670.561383323664 3763.269238105613 3914.806624013999 3905.2446380966494 3812.6584127914075 3932.2852428095466 3923.695394766043 3547.205215415825 3326.7430238739503 1.139618219475428 1.103349840063493 1.1312172930397653 1.1767685679115836 1.1738942894209607 1.1460633975724446 1.1820225411430938 1.1794404817589275 1.0662696787698225 1.0 11.699894713401276 -8.481311089129335 3.676652437648155 1.0007035591739029 1.153337081616347 0.8128934519945796 0.02419556383520143 0.0894516051411695 2.714453318286238 0.026290968453668528 0.006927455318757436 3.301329790337633e-09 8.481311089129335 0.1526335224424442 SPLDPMT(ph)SPGSGLILQANFVHSQR ddPTM_A459_Selumetinib_30min_R1 1 SPLDPMTSPGSGLILQANFVHSQR 24 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9 A0A1B0GW84;Q08499-6;Q08499-9 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 S(0.124)PLDPMT(0.492)S(0.379)PGS(0.004)GLILQANFVHSQR 79.365 0.00046137 11181000.0 1488.6 1378.6 1829.4 1684.6 1637.3 1721.4 1710.2 1290.8 824.25 1184.6 True False 1523.2814836886216 1217.1928711062471 1580.9775281748975 1390.4162338584429 1489.206504088794 1704.0842789061458 1581.1982371100805 1256.5637908906897 1398.692049161868 1336.654948981136 1.1396220728840616 0.910626090925 1.1827865743361787 1.04022076521565 1.1141293459646713 1.2748871952369476 1.1829516946878083 0.9400809025908327 1.0464122025119644 1.0 10.384411373398505 -7.764411495879776 24.999092073797673 0.9949349136874099 1.1176277382086577 0.27137343552017257 0.09394972162475518 115.67107823009547 972897.4450529476 0.0512090682056727 0.026282585630117383 1.7202378698160804e-08 7.764411495879776 0.12269282452124775 SPLDPMT(ph)SPGSGLILQANFVHSQR ddPTM_A459_Selumetinib_30min_R2 1 SPLDPMTSPGSGLILQANFVHSQR 24 0 A0A1B0GW84;Q08499-11;Q08499-2;Q08499-10;A0A087WSZ7;Q08499;A0A1W2PQN6;Q08499-6;Q08499-7;Q08499-12;Q08499-9 A0A1B0GW84;Q08499-6;Q08499-9 PDE4D cAMP-specific 3,5-cyclic phosphodiesterase 4D 1 S(0.188)PLDPMT(0.418)S(0.372)PGS(0.021)GLILQANFVHSQR 55.022 0.02143 5718900.0 36248.0 23273.0 31561.0 37869.0 30700.0 23559.0 34507.0 32922.0 29084.0 33551.0 True False 34233.48127224092 25057.96426551038 29530.399621018594 32711.17687233127 26843.191538517764 26804.038402691065 36111.64387432332 33017.79756946952 34901.61267485749 32582.295454033094 1.0506773938176734 0.7690668786937375 0.9063326941676011 1.0039555659447015 0.8238582077922648 0.8226565387483531 1.108321048934978 1.0133662195793058 1.0711833585849246 1.0 14.9918006262457 -7.263824585771215 24.999574578203177 1.0493315101024068 0.8924025077940844 0.44151155271297593 0.08375437529605866 198.45832942506172 2080041.9937407011 0.03328579130688816 0.02362572622400954 5.447226252545682e-08 7.263824585771215 -0.1569290023083224 SPLEHSS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 SPLEHSSPEK 10 0 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 SPLEHS(0.038)S(0.961)PEK 75.08800000000002 0.040235 6827600.0 65004.0 47262.0 58476.0 61852.0 61839.0 57000.0 85393.0 87392.0 65538.0 47224.0 True False 61391.3379116296 50886.843428717875 54713.71782385488 53427.65089934866 54070.23197232571 64851.23260551763 89363.94370301942 87646.29625147565 78647.43128472049 45860.52041731272 1.3386533199578317 1.1096002174782926 1.1930461609676808 1.1650031533261729 1.179014792686778 1.4140971802194324 1.948602913570161 1.9111491857032756 1.7149267075266428 1.0 15.4849651060167 -7.014434680676597 4.309426713322478 1.7193705338494387 1.1949053529288007 0.39592462208406765 0.252631197116971 0.17306901887444567 7.743929703746022 0.09168472706859211 0.07459211897846481 9.673092022062145e-08 7.014434680676597 -0.524465180920638 SPLELGEKLS(ph)PLPGGPGAGDPR ddPTM_A459_Selumetinib_30min_R1 1 SPLELGEKLSPLPGGPGAGDPR 22 1 Q15742;Q15742-2;Q15742-3 Q15742 NAB2 NGFI-A-binding protein 2 1 S(0.001)PLELGEKLS(0.999)PLPGGPGAGDPR 50.14 0.029753 21916000.0 3853.7 4123.6 4843.7 4944.0 3665.8 3508.9 3924.9 3761.2 2306.4 3207.2 True False 3943.483712005132 3640.8069949903693 4185.952144539602 4080.623210374059 3334.2290372495577 3473.6036518262913 3628.8416330448827 3661.4407579005724 3913.792347208894 3618.8753607735116 1.0896986822895822 1.0060603452814605 1.1566997277421793 1.1275942947926927 0.9213439825506694 0.9598572223509324 1.002753969473334 1.0117620511577836 1.081494098866214 1.0 11.821325704754278 -6.246583490003182 24.999009542909658 0.9953003580376071 1.093065660762922 0.461432819462132 0.05227479462278526 823.4521012904488 1385678.4177193642 0.016480276545989332 0.021183256611633266 5.667826011540773e-07 6.246583490003182 0.09776530272531503 SPLELGEKLS(ph)PLPGGPGAGDPR ddPTM_A459_Selumetinib_30min_R2 1 SPLELGEKLSPLPGGPGAGDPR 22 1 Q15742;Q15742-2;Q15742-3 Q15742 NAB2 NGFI-A-binding protein 2 1 S(0.004)PLELGEKLS(0.996)PLPGGPGAGDPR 54.74 0.014781 7233800.0 37786.0 36556.0 32078.0 29855.0 30989.0 28964.0 28166.0 35094.0 25026.0 29905.0 True False 35686.00538934271 39359.727653933616 30014.13640388562 25788.69749725237 27095.884774825 32953.528090986205 29475.774809870174 35196.11772987556 30031.899284863943 29041.564947478728 1.2287907161298077 1.355289486813646 1.0334889479325846 0.8879926940538803 0.9330036044485736 1.134702215620343 1.0149513245300903 1.2119222154015203 1.034100584427052 1.0 14.825831576723845 -5.270281221666089 24.579389137512422 1.0333234455275442 1.2920401029277726 0.5677477415693766 0.09099992776419426 342.8409859382517 953064.3072417862 0.025527370318858347 0.054465936827589656 5.3668416107612564e-06 5.270281221666089 0.2587166574002284 SPLGEAPPGT(ph)PPCR ddPTM_A459_Selumetinib_30min_R2 1 SPLGEAPPGTPPCR 14 0 M0QXZ5;Q96B54 M0QXZ5 ZNF428 Zinc finger protein 428 1 S(0.35)PLGEAPPGT(0.65)PPCR 108.66 0.011264 19023000.0 34566.0 24506.0 27360.0 26004.0 32960.0 25111.0 22880.0 26902.0 19659.0 25844.0 True False 32644.96009866142 26385.53140079049 25599.687387315647 22462.21034059792 28819.27013386141 28569.81231503777 23943.965335859913 26980.280366134142 23591.349318354547 25097.816569223887 1.300709167613098 1.0513078429756977 1.0199965927995178 0.8949866327472539 1.1482779808503718 1.138338557708299 0.954025832080593 1.0750050822834771 0.9399761629975159 1.0 14.61527423927251 -4.7600489180844345 4.263262740827878 1.0262404368512337 1.327505793752665 0.5336863319187126 0.07775109480664656 0.18505344530368545 6.830574180972558 0.0197615574502015 0.17490775138616196 1.73760509727288e-05 4.7600489180844345 0.3012653569014314 SPLLAGGS(ph)PPQPVVPAHK ddPTM_A459_Selumetinib_30min_R1 2 SPLLAGGSPPQPVVPAHK 18 0 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4;C9JIY9 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 SPLLAGGS(1)PPQPVVPAHK;S(0.001)PLLAGGS(0.999)PPQPVVPAHK 148.2 0.00013266 190118000.0 11310.7 12585.0 12858.8 12523.5 12562.1 10499.4 11713.5 10786.2 5649.799999999999 10360.8 True False 11574.217303208994 11111.542349392228 11112.645588332445 10336.505820210254 11425.860273018883 10393.785568692449 10829.941264407047 10500.114937484615 9587.297954934442 11690.709602738276 0.990035480865764 0.9504591874208909 0.9505535562810975 0.8841641073514621 0.9773453161767565 0.8890637028789037 0.9263715918382223 0.8981589051724634 0.820078359716406 1.0 13.513074880786117 -3.7406005558340936 0.5145335041129306 0.9056005176110626 1.1930055487045867 0.1941824413092087 0.04788429412053955 17.930325545049808 1.6042079187033202 0.025854750690536478 3.9200360764902507 0.00018171862590474604 3.7406005558340936 0.2874050310935241 SPLLAGGS(ph)PPQPVVPAHK ddPTM_A459_Selumetinib_30min_R2 2 SPLLAGGSPPQPVVPAHK 18 0 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4;C9JIY9 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 SPLLAGGS(1)PPQPVVPAHK;S(0.003)PLLAGGS(0.997)PPQPVVPAHK 112.91 0.0012022 79745500.0 146039.0 119690.0 144674.0 161651.0 181763.0 141150.0 134797.0 153364.0 135466.0 156218.0 True False 137922.7370204367 128869.83813599177 135365.83234914104 139633.8549364709 158928.30695816307 160592.13126787398 141065.32759518828 153810.26384922303 162562.98523628933 151707.58043689097 0.9091354342561105 0.8494620886106643 0.8922812687362847 0.9204144877556554 1.0475963462107674 1.0585636578303936 0.9298502236272249 1.0138601077564924 1.0715547948766746 1.0 17.210933649576653 -6.097599554087768 3.7393517913705807 1.0180230331699252 0.8826154299256432 0.7180196736363502 0.03950336764585529 0.13468806109276213 3.4387857722229067 0.012506947853238333 0.016902145804876062 7.987308262084532e-07 6.097599554087768 -0.13540760324428192 SPLLNS(ph)PTVAK ddPTM_A459_Selumetinib_30min_R1 1 SPLLNSPTVAK 11 0 O43365 O43365 HOXA3 Homeobox protein Hox-A3 1 S(0.281)PLLNS(0.601)PT(0.119)VAK 95.264 0.021395 8116700.0 1668.9 1841.5 2149.5 2273.8 1914.0 1820.0 1852.3 1726.2 995.89 1441.0 True False 1707.7821228858938 1625.8963239098762 1857.609706358338 1876.723514512244 1740.8790379441455 1801.6924524277824 1712.5795197047148 1680.4155685121693 1689.9525930722632 1625.9663865286325 1.0503182212345326 0.9999569101678013 1.1424650114226862 1.1542203640008617 1.070673448336682 1.108074845430426 1.0532687107763634 1.033487274051085 1.0393527240622966 1.0 10.667081717665617 -7.552714364734881 2.722007341030237 1.0262927122310872 1.0883781013535203 0.3072966117263276 0.04268917040274076 0.4025379076276102 6.0277160999905 0.025314450861231998 0.013640515948775614 2.800822813767087e-08 7.552714364734881 0.06208538912243311 SPLPAGPSSCT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 SPLPAGPSSCTSPR 14 0 Q8N3V7-2 Q8N3V7-2 SYNPO Synaptopodin 1 SPLPAGPS(0.006)S(0.025)CT(0.732)S(0.237)PR;SPLPAGPS(0.002)S(0.01)CT(0.852)S(0.135)PR 101.72 0.018919 30794000.0 107734.0 105281.0 123024.0 135012.0 138758.0 94422.0 116326.0 100089.0 102803.0 118052.0 True False 101746.57557337233 113355.7141682291 115108.76977840363 116623.13269130941 121325.97952774087 107427.7734224243 121735.38949559597 100380.242419374 123366.47255581665 114643.53202406835 0.8875038458516054 0.9887667639586603 1.0040581247465195 1.01726744311075 1.0582889185782378 0.9370591739957108 1.0618600748452058 0.875585745197558 1.0760875068810425 1.0 16.806795437466953 -4.758548340623325 3.884784632532123 1.001260582448491 0.8736464856557498 0.26790975213736734 0.05718965218971377 0.3532000843087048 9.550648379453127 0.013301410532724448 0.13303490391017736 1.7436192671956047e-05 4.758548340623325 -0.12761409679274127 SPLS(ph)PTETFSWPDVR ddPTM_A459_Selumetinib_30min_R1 1 SPLSPTETFSWPDVR 15 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.043)PLS(0.949)PT(0.008)ETFSWPDVR 225.31 2.7266e-10 19049000.0 732.91 755.55 1017.0 802.59 795.06 653.31 813.17 693.68 409.03 562.63 True False 749.9853770053932 667.0898547543344 878.8969859811252 662.4327229802012 723.1469633792434 646.7382945580196 751.8319322130769 675.2813530098025 694.09403563079 634.8490409802941 1.1813601794960777 1.0507850082348018 1.3844188606223418 1.043449198501291 1.1390849110563437 1.0187276861273458 1.1842688319291546 1.0636880729426248 1.093321389536973 1.0 9.310269767926235 SPLSPT(ph)ETFSWPDVR ddPTM_A459_Selumetinib_30min_R1 1 SPLSPTETFSWPDVR 15 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.013)PLS(0.417)PT(0.566)ET(0.004)FSWPDVR 118.19 0.0048018 20262000.0 1075.8 1102.0 1550.0 1498.0 1499.7 1334.3 849.88 931.49 605.38 1094.1 True False 1100.864046857597 972.9773276940992 1339.518513540555 1236.4024209426248 1364.0523997935402 1320.8781534474667 785.7728673576868 906.7838592940566 1027.28564479419 1234.5383924364853 0.8917211919873399 0.7881304734264529 1.085035930633863 1.0015098991797742 1.1049088535038962 1.0699368780589975 0.6364912360537328 0.7345124824384179 0.8321212617509114 1.0 10.269755987660774 -7.25075600189381 24.983116056334577 0.7786572809949097 0.9910597667481148 0.3545781573852267 0.12376726558536637 750.8392061783424 1755843.124232384 0.04958684801352009 0.03800503924894241 5.613632761618865e-08 7.25075600189381 0.21240248575320508 SPLSPT(ph)ETFSWPDVR ddPTM_A459_Selumetinib_30min_R2 1 SPLSPTETFSWPDVR 15 0 A1L390-3;A1L390;G3V311;A1L390-2 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.268)PLS(0.223)PT(0.392)ET(0.112)FS(0.006)WPDVR 117.48 0.0049943 1525600.0 2887.8 1238.9 2725.4 2927.3 2412.9 392.72 2135.7 838.99 816.16 972.98 True False 2727.307636779333 1333.9196463086328 2550.0507311911547 2528.5966901258384 2109.76993040031 446.81361524278736 2235.0142818092654 841.4313219977286 979.4148054157498 944.8875392943615 2.886383324322465 1.411723184861554 2.698787554226319 2.6760821631896903 2.232826492744182 0.4728749154385781 2.3653759721271865 0.8905094913476225 1.036541138162509 1.0 9.883998819471142 -6.6347418566099705 7.924314322093763 1.2245524592436663 2.3764602648470574 0.5216667474277665 0.5874181786910339 0.20859492926553966 13.756484348758029 0.18913209801229125 0.18893440251327887 2.318772512136434e-07 6.6347418566099705 1.1519078056033911 SPMFPALGEAS(ph)SDDDLFQSAKPK ddPTM_A459_Selumetinib_30min_R1 1 SPMFPALGEASSDDDLFQSAKPK 23 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;Q5SRD0;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21D;FAM21A WASH complex subunit FAM21C;Putative WASH complex subunit FAM21;WASH complex subunit FAM21A 1 SPMFPALGEAS(0.872)S(0.128)DDDLFQSAKPK 121.56 5.799e-06 12322000.0 1182.2 1477.2 1133.1 1273.4 1050.2 1573.6 1233.2 1035.3 703.43 1172.9 True False 1209.7429598392382 1304.248737268352 979.2312436727761 1051.0245946784637 955.2095954278699 1557.771012714484 1140.1787311449839 1007.8404808716538 1193.6693335055295 1323.4531400134854 0.9140806903272083 0.985489170591308 0.7399062453112607 0.7941532366365115 0.7217555095438716 1.177050373463628 0.8615180218117628 0.7615233591582883 0.901935472753774 1.0 10.370091398371864 SPMFPALGEAS(ph)SDDDLFQSAKPKPAK ddPTM_A459_Selumetinib_30min_R2 1 SPMFPALGEASSDDDLFQSAKPKPAK 26 2 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;Q5SRD0;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21D;FAM21A WASH complex subunit FAM21C;Putative WASH complex subunit FAM21;WASH complex subunit FAM21A 1 SPMFPALGEAS(0.482)S(0.482)DDDLFQS(0.036)AKPKPAK 54.582 0.004596 2509000.0 12399.0 9578.1 10470.0 11559.0 9390.3 6298.5 8883.4 7623.0 7661.5 8183.4 True False 11709.913217129637 10312.709471554379 9796.371598874075 9984.644259612805 8210.606563652877 7166.061202909699 9296.495702123157 7645.181667944412 9194.014080196004 7947.123978973334 1.4734781095792604 1.2976656081923423 1.2326939437202087 1.256384609832486 1.0331544575593221 0.9017175549129236 1.1697937174152586 0.962006090275198 1.1568982822618243 1.0 12.956217136005943 -5.460191237983029 0.8439443171889006 1.0334522297405868 1.486174179277198 0.7075399651094874 0.0901931649887148 0.6024916815750732 0.6289374828610813 0.037370352329706424 0.2121646312787813 3.4658420135966667e-06 5.460191237983029 0.45272194953661127 SPNPST(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SPNPSTPR 8 0 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 SPNPS(0.025)T(0.975)PR;SPNPS(0.003)T(0.997)PR;SPNPST(1)PR;SPNPS(0.003)T(0.997)PR 118.03 0.020036 329527000.0 509348.0 483850.0 440120.0 540721.0 581432.0 405226.0 476882.0 485304.0 504756.0 593649.0 True False 481040.4772415952 520959.7391770366 411803.15836642456 467073.8670042471 508387.31409197 461042.2032246228 499057.9579237562 486716.1542935981 605721.3040610079 576508.8108846623 0.8344026459950034 0.9036457541344689 0.7143050558663723 0.8101764590336694 0.881837891274968 0.799714062508682 0.8656553872228657 0.844247555465326 1.050671373316079 1.0 19.13698313144217 -8.238251215570195 7.957197329143826 1.0255070409486253 0.831047564325793 0.7011397586564923 0.05055581796646621 0.10810230179031528 33.17737510647615 0.03638552759287723 0.012981844310329414 5.777617472028149e-09 8.238251215570195 -0.19445947662283236 SPPAS(ph)PESWK ddPTM_A459_Selumetinib_30min_R2 2 SPPASPESWK 10 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 S(0.017)PPAS(0.983)PESWK;S(0.063)PPAS(0.937)PESWK 148.78 0.00077327 17251300.0 194544.0 182944.0 179556.0 228661.0 206267.0 183918.0 194087.0 172474.0 157799.0 200390.0 True False 183732.0233013363 196975.2165423251 168003.56244579077 197516.9773377735 180353.8954096235 209251.0350586247 203112.4300760946 172975.8707853921 189363.20927244655 194604.22002425257 0.9441317525305396 1.0121836850083572 0.8633089376214622 1.0149675958371198 0.9267727872866626 1.0752646321469634 1.0437205835042103 0.8888598138510817 0.9730683602279906 1.0 17.570183469972328 SPPGQVTEAVK ddPTM_A459_Selumetinib_30min_R2 1 SPPGQVTEAVK 11 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 156.58 0.007605800000000002 4723700.0 20452.0 15629.0 19122.0 19376.0 22059.0 15842.0 16435.0 14532.0 12978.0 20531.0 False True 19315.359715842842 16827.694044844317 17891.71133845941 16736.955374535664 19287.751210037888 18024.09170064229 17199.260065334678 14574.285714097896 15573.962635617532 19938.216684055707 0.9687606480517912 0.8439919332555539 0.8973576534940129 0.8394409409704107 0.9673759451848075 0.9039971822081704 0.8626278035732587 0.7309723805816963 0.7811111135165762 1.0 14.283248757383692 -7.52831614573208 24.70018146605362 0.8129850535692842 0.8990651884109048 0.10851458377658652 0.07671752597271408 200.97967178438168 912956.0405861973 0.0341713076907654 0.01981165116041998 2.962673918614185e-08 7.52831614573208 0.08608013484162058 SPPLIGS(ph)ESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 1 SPPLIGSESAYESFLSADDKASGR 24 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.368)PPLIGS(0.577)ES(0.053)AY(0.002)ESFLSADDKASGR 84.70700000000002 6.2814e-05 39863000.0 1662.6 1363.7 1746.7 1446.1 1798.2 1573.1 1651.6 1691.5 913.89 1236.0 True False 1701.3353451435596 1204.0373700330695 1509.507733936314 1193.5657816589658 1635.5531274979949 1557.2760422605197 1527.0184822892115 1646.6359252336545 1550.8045821153041 1394.652639659534 1.2198989890119833 0.8633241968602318 1.0823539073534603 0.8558158122802119 1.1727315325608747 1.1166049509221778 1.0949095415342927 1.1806781691788395 1.111964755965249 1.0 10.445690125395243 -6.297291262866606 24.998401799239534 1.1211429778748652 1.000703931314905 0.18969503638145735 0.10782089124103017 845.5714599476652 589588.2543451389 0.031040375191262504 0.03519758207289219 5.043229561300978e-07 6.297291262866606 -0.12043904655996007 SPPLLES(ph)PDATR ddPTM_A459_Selumetinib_30min_R1 3 SPPLLESPDATR 12 0 Q15036-2;Q15036 Q15036-2 SNX17 Sorting nexin-17 1 S(0.003)PPLLES(0.997)PDATR;SPPLLES(0.912)PDAT(0.088)R;SPPLLES(1)PDATR 145.61 0.00067846 49078000.0 3009.25 3540.3999999999996 3314.4199999999996 3613.6 3768.3999999999996 2738.04 3571.5 2754.25 1645.5700000000002 2511.31 True False 3079.359670018802 3125.888322112693 2864.33996880586 2982.552595673079 3427.5488853650563 2710.4978035414097 3302.0988795688536 2681.1983429351426 2792.412102322469 2833.6611007308934 1.0867071115965614 1.1031270893002783 1.0108265833437362 1.0525438609803344 1.2095832082675588 0.9565356290638581 1.165311857059101 0.9461958391014276 0.9854432139405149 1.0 11.468451510267673 -7.782297661674144 24.99935250215915 0.9743646061723037 1.0802508785348206 0.3346195709762647 0.06855181683839827 281.22892669881367 337057.466985478 0.03552664913263244 0.017095467086524995 1.650829945854219e-08 7.782297661674144 0.10588627236251691 SPPLLES(ph)PDATR ddPTM_A459_Selumetinib_30min_R2 3 SPPLLESPDATR 12 0 Q15036-2;Q15036 Q15036-2 SNX17 Sorting nexin-17 1 SPPLLES(0.878)PDAT(0.122)R;SPPLLES(0.989)PDAT(0.011)R;SPPLLES(1)PDATR 136.33 0.0014159 47958300.0 31851.0 34468.9 31814.6 32896.9 35413.8 19341.199999999997 25609.199999999997 27795.7 21011.3 28051.5 True False 30080.848929655313 37112.55379501788 29767.68327311738 28416.285469682185 30964.80184061108 22005.274738067328 26800.07854366711 27876.580885174146 25214.147104773525 27241.58030845009 1.1042255474556484 1.362349517715237 1.0927296777963984 1.0431217700269655 1.1366742123622717 0.8077826061816792 0.9837930927727409 1.0233099757625692 0.9255757859595365 1.0 14.733522777357331 -5.874563502830818 1.1794281000557494 0.9627520001461795 1.2329008438054332 0.4989081469477219 0.09798243729775899 0.4003576987987838 1.1165220636568887 0.03564860752165125 0.08171443927655105 1.3348623908163884e-06 5.874563502830818 0.27014884365925373 SPPLS(ph)PVGTTPVK ddPTM_A459_Selumetinib_30min_R1 1 SPPLSPVGTTPVK 13 0 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 S(0.149)PPLS(0.678)PVGT(0.165)T(0.008)PVK 136.33 0.0014995 0.0 1591.0 1471.6 1642.5 1695.2 1549.0 1447.0 1413.1 1442.3 984.87 1059.9 True False 1628.0672044529067 1299.3043878717199 1419.4575216066842 1399.1651428450866 1408.8932234981623 1432.4444937708806 1306.5087293066636 1404.0455187493346 1671.2524579412168 1195.9484893002757 1.3613188352329912 1.0864216975029715 1.1868885109233918 1.1699209082689745 1.1780551053017978 1.1977476509953817 1.09244565380159 1.174001665883463 1.3974284619223287 1.0 10.223939537215315 -4.744914224160252 24.73559438306822 1.170243395605445 1.3613194662940773 0.2668516098331507 0.0973566868979742 1188.171827543329 1778399.5530920909 0.02305690440012248 0.6074754883731466 1.799226238321564e-05 4.744914224160252 0.1910760706886323 SPPLS(ph)PVGTTPVK ddPTM_A459_Selumetinib_30min_R2 1 SPPLSPVGTTPVK 13 0 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 SPPLS(0.982)PVGT(0.015)T(0.004)PVK 125.73 0.0020994 12951000.0 44169.0 40169.0 52438.0 58376.0 57331.0 42170.0 41893.0 43802.0 44049.0 59074.0 True False 41714.26380251626 43249.833136307556 49064.19617017755 50425.088095783125 50128.56723435708 47978.53471885403 43841.107509404676 43929.45656818855 52860.03083189372 57368.38012731514 0.72712988775248 0.7538967117482678 0.8552480662917712 0.8789700525599107 0.8738013366092774 0.836323678869394 0.7642033366134797 0.7657433671771423 0.921414038789029 1.0 15.807968161696854 -14.522878745262028 0.19609423746330124 1.8037673496663373 0.7891179959010834 0.5033926296516936 0.0574642299007446 135.6079395549004 1.3325220037035928 42.61007767997149 0.16014734650462764 3.0000000001264748e-15 14.522878745262028 -1.014649353765254 SPPLSPVGTT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 SPPLSPVGTTPVK 13 0 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 SPPLSPVGT(0.04)T(0.96)PVK 180.85 0.00026517 8514100.0 61523.0 51750.0 60236.0 64666.0 69994.0 51899.0 51716.0 49470.0 49861.0 59387.0 True False 58103.7979560825 55719.05859752343 56360.48133999797 55858.379244927884 61200.72796570077 59047.61615778524 54120.89647330992 49613.94950980063 59834.59323274201 57672.34300404347 1.007481141385374 0.9661313498849337 0.9772531928527072 0.9685470770801109 1.0611798442350422 1.0238463201268821 0.9384202835233423 0.8602728262023643 1.0374919782355112 1.0 15.815592014249846 SPPPS(ph)PPTHR ddPTM_A459_Selumetinib_30min_R1 2 SPPPSPPTHR 10 0 Q96HA1 Q96HA1 POM121 Nuclear envelope pore membrane protein POM 121 1 SPPPS(0.992)PPT(0.008)HR;SPPPS(0.997)PPT(0.002)HR 91.62 0.018373 2292300.0 126.69 450.25 448.49 331.07 300.65999999999997 121.17 234.92000000000002 188.03 0.0 184.65 True False 129.6416305041727 397.53452068445404 387.58752137922784 273.2548394535881 273.4653560858344 119.95113981355743 217.19979526482288 183.04283359248234 0.0 208.35162614331145 0.622225191633497 1.9079981665754606 1.860256761867708 1.3115080717711027 1.312518462888 0.5757149201756212 1.0424674829051988 0.8785284616237128 0.0 1.0 7.70287654980912 -6.647622151437306 3.9156603106796246 0.7127073156822843 1.4749024337124652 0.3997042375644282 0.42945626362191186 0.23190990522364616 6.616326355927815 0.1476994811597854 0.1464801123994884 2.2510121988259785e-07 6.647622151437306 0.7621951180301809 SPPPS(ph)PPTHR ddPTM_A459_Selumetinib_30min_R2 2 SPPPSPPTHR 10 0 Q96HA1 Q96HA1 POM121 Nuclear envelope pore membrane protein POM 121 1 SPPPS(0.999)PPT(0.001)HR;S(0.01)PPPS(0.988)PPT(0.002)HR 92.039 0.018409 2805400.0 2425.3999999999996 3128.5299999999997 4686.0 3609.47 4590.6 2265.8 3757.2 2059.33 703.9 1382.0700000000002 True False 2290.605977645474 3368.478191190528 4384.507861731034 3117.8539593169507 4013.887787515301 2577.8933831154714 3931.917244750558 2065.322309359565 844.6996686092758 1342.1660480508929 1.706648727236034 2.509732827828767 3.2667402577335793 2.3230016612659288 2.9906044735256936 1.920696315377009 2.929531148892142 1.538797909810673 0.6293555628500342 1.0 10.390347452385285 -7.962286882511358 4.019436940832776 0.8625920239834708 2.5335034422439606 0.6958421510762933 0.45915542519393343 0.11421741349686981 3.9641748422577106 0.28666018697011114 0.12010589579914722 1.0907196002592014e-08 7.962286882511358 1.6709114182604898 SPPREGS(ph)QGELTPANSQSR ddPTM_A459_Selumetinib_30min_R1 2 SPPREGSQGELTPANSQSR 19 1 C9JFE4;A0A096LP07;A0A096LPJ3;A8K070;Q13098-5;Q13098;Q13098-7;J3QQX0 C9JFE4 GPS1 COP9 signalosome complex subunit 1 1 S(0.102)PPREGS(0.898)QGELTPANSQSR;SPPREGS(0.999)QGELTPANSQSR 92.8 0.001194 13453000.0 1032.69 1152.47 1657.8000000000002 1887.04 1734.69 1149.19 1220.0500000000002 787.88 738.22 903.37 True False 1056.7496677350546 1017.5382766312327 1432.6798656435683 1557.5038881278842 1577.7875957843942 1137.6301919810346 1128.0206462321105 766.9828630050794 1252.705422544464 1019.3263390689585 1.0367137855971407 0.9982458390711664 1.4055163795258763 1.5279737493592986 1.547872879676128 1.1160608221113304 1.1066334725171845 0.7524409343779276 1.2289542362739998 1.0 9.993400291399805 -7.062289787337168 3.43212256996603 1.003828365050971 1.3059328923439204 0.2922127547003165 0.20387970228778673 0.33515643408386525 7.775371047967719 0.08911855869594038 0.06969241226752694 8.663835797330169e-08 7.062289787337168 0.30210452729294945 SPPS(ph)PATDQR ddPTM_A459_Selumetinib_30min_R2 1 SPPSPATDQR 10 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 1 S(0.004)PPS(0.992)PAT(0.004)DQR 96.23 0.021921 7013300.0 21660.0 20801.0 29047.0 26397.0 26684.0 20537.0 16980.0 13927.0 19309.0 25555.0 True False 20456.22391184999 22396.36981424316 27178.147643982342 22801.683062635097 23331.717362013304 23365.785333675707 17769.603645231684 13967.52526426104 23171.339538537453 24817.160750136074 0.8242773666902177 0.9024549600872598 1.0951352540936143 0.9187869350650869 0.9401445071384879 0.9415172657713309 0.7160208141511213 0.5628172136566612 0.933682131160407 1.0 14.599050450456705 -7.250488523175826 23.83030054134922 0.7666981437420715 0.9419759508833568 0.1847605896657113 0.12878779901947843 484.0162128996118 1053275.2837171948 0.04870009936127252 0.037303252774343695 5.61709122089373e-08 7.250488523175826 0.17527780714128538 SPPS(ph)PVER ddPTM_A459_Selumetinib_30min_R1 2 SPPSPVER 8 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 S(0.011)PPS(0.989)PVER;SPPS(1)PVER 110.54 0.011981 1534070000.0 1586.1399999999999 2070.61 1848.08 2326.94 2181.07 1724.33 1995.0500000000002 2116.02 790.78 1246.87 True False 1623.0939759088212 1828.1820185995257 1597.1208867767923 1920.5836110735856 1983.7926035991838 1706.9848057663728 1844.5617722760292 2059.8962757983545 1341.8959037139473 1406.9179100423007 1.1536522240021956 1.2994233747046118 1.1351912399272626 1.3650999801515362 1.4100272584770341 1.2132796047176984 1.31106566993704 1.4641197337067244 0.9537840794660163 1.0 10.458322438233068 -8.279201267665705 24.83572337841342 0.9768919192631574 1.2929888125859688 0.6159809045865334 0.10014403862010408 571.1576353398407 798617.910588768 0.0961628112277614 0.025047091351251417 5.257735475697584e-09 8.279201267665705 0.3160968933228113 SPPS(ph)TGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 1 SPPSTGSTYGSSQK 14 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.131)PPS(0.681)T(0.141)GS(0.044)T(0.003)YGSSQK 121.92 0.0018495 72211000.0 15005.0 8049.5 13985.0 17813.0 16743.0 17437.0 21121.0 21534.0 22845.0 12271.0 True False 14171.082169774189 8666.870766778056 13085.220325716706 15386.838670861058 14639.594655680889 19838.788472673874 22103.168350467527 21596.660374854397 27414.638342632337 11916.704346113082 1.1891779604649189 0.7272875549358547 1.0980569749542175 1.2911991624496284 1.2284935692355197 1.6647881743533202 1.85480546537827 1.8123014339865422 2.300521817642835 1.0 13.540697682386275 -6.574484479106924 1.231788549541886 1.8228937609545675 0.9973665190069642 0.4706265276433439 0.3289859767806905 0.3493044421317096 1.1124351158585821 0.14389376781650343 0.1546714196669469 2.66388529747017e-07 6.574484479106924 -0.8255272419476033 SPPSS(ph)SEIFTPAHEENVR ddPTM_A459_Selumetinib_30min_R2 1 SPPSSSEIFTPAHEENVR 18 0 I3L2L5;I3L3A7;I3L317;I3L4Q0;C9JLW8 I3L2L5 FAM195B Protein FAM195B 1 S(0.116)PPS(0.401)S(0.406)S(0.077)EIFTPAHEENVR 118.55 0.00065802 9692000.0 3572.6 2742.1 5434.8 2171.3 3744.2 4991.1 3918.7 5323.1 2294.0 3669.2 True False 3374.049194250936 2952.4102527588198 5085.13088496283 1875.5651942985785 3273.820122427302 5678.578720305248 4100.927314756736 5338.589339713356 2752.8640997154116 3563.260662273499 0.9468993469869144 0.8285698220222449 1.4271004472960223 0.5263620520823461 0.918770876655001 1.5936467349773098 1.1508917543349706 1.498231492362147 0.772568824072213 1.0 11.798982309085929 SPPTTMLLPAS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 SPPTTMLLPASPAK 14 0 Q9UGU5 Q9UGU5 HMGXB4 HMG domain-containing protein 4 1 SPPTTMLLPAS(1)PAK;SPPTTMLLPAS(1)PAK 133.23 0.00074333 13929200.0 47235.0 40123.0 39695.0 35279.0 42369.0 37219.0 48323.0 55030.0 40239.0 33542.0 True False 44609.867796686674 43200.30508422091 37141.06691664818 30473.9393403305 37046.22743633418 42345.579409557235 50570.11525020793 55190.128189293064 48287.92437159915 32573.555307417897 1.3695117826615562 1.3262385599763808 1.1402214638876136 0.9355423150076204 1.137309915565088 1.2999986955649874 1.5524898885904455 1.6943231301719388 1.482427199483584 1.0 14.991413573782824 -7.047964743081935 3.918019206512759 1.4878522840139923 1.175633951698665 0.23698377663826742 0.20156751850470012 0.27396697501016826 8.703434740557098 0.0800750475030845 0.06333677672631594 8.95437456050848e-08 7.047964743081935 -0.31221833231532736 SPPVLGSAAAS(ph)PVHLK ddPTM_A459_Selumetinib_30min_R2 1 SPPVLGSAAASPVHLK 16 0 O00512 O00512 BCL9 B-cell CLL/lymphoma 9 protein 1 SPPVLGS(0.001)AAAS(0.999)PVHLK 98.188 0.004776 6727400.0 66017.0 62592.0 65851.0 63258.0 64747.0 49036.0 59012.0 59770.0 45085.0 62769.0 True False 62348.0394269899 67392.60513499862 61614.218353147706 54642.15127386339 56612.903014475865 55790.263895511634 61756.174930059606 59943.92080454385 54103.259780152315 60956.695876552156 1.022825114295162 1.105581661963442 1.010786714521521 0.8964093359739049 0.9287396929965951 0.9152442253185206 1.0131155247509893 0.9833853351556431 0.8875687732438905 1.0 15.895497084025987 -5.536678764037495 6.355768717111644 0.9466249553973399 1.0632381930203534 0.5416695580051376 0.04402091794322706 0.10619569347049827 17.6391138244137 0.012001479727051694 0.021913312894701286 2.906171476630885e-06 5.536678764037495 0.11661323762301345 SPQDPGDPVQY(ph)NRTTDEELSELEDR ddPTM_A459_Selumetinib_30min_R2 1 SPQDPGDPVQYNRTTDEELSELEDR 25 1 H7C3K9;H7C052;Q9BV36-5;Q9BV36;Q9BV36-4;Q9BV36-2;H7C2D8 H7C3K9;Q9BV36;Q9BV36-2 MLPH Melanophilin 1 SPQDPGDPVQY(0.365)NRT(0.317)T(0.317)DEELS(0.002)ELEDR 65.207 0.020669 4431800.0 13161.0 20635.0 19092.0 17748.0 14544.0 5516.9 4637.5 4435.7 3334.9 14140.0 True False 12429.56430765732 22217.638148017286 17863.641505797874 15330.691782992304 12716.852694990312 6276.8028975680745 4853.152939031917 4448.607152630332 4001.9731848914244 13731.741459867895 0.9051702833164831 1.6179767302603314 1.3009013866162413 1.1164419187324104 0.9260917657207808 0.45710173876434607 0.35342588944130954 0.3239652571111785 0.29143959610567305 1.0 13.745226979265894 -6.513715931430907 1.805330186564666 0.42254937612696397 1.2903379658334493 0.6586618237040507 0.253373470232452 0.1885746012811518 1.2404378359664379 0.09219010308817283 0.10109850900108505 3.0639668947905123e-07 6.513715931430907 0.8677885897064853 SPQDPGDPVQYNRT(ph)TDEELSELEDR ddPTM_A459_Selumetinib_30min_R1 2 SPQDPGDPVQYNRTTDEELSELEDR 25 1 H7C3K9;H7C052;Q9BV36-5;Q9BV36;Q9BV36-4;Q9BV36-2;H7C2D8 H7C3K9;Q9BV36;Q9BV36-2 MLPH Melanophilin 1 SPQDPGDPVQY(0.001)NRT(0.499)T(0.499)DEELSELEDR;SPQDPGDPVQY(0.021)NRT(0.489)T(0.489)DEELSELEDR 118.46 1.0741e-07 20330400.0 1669.96 1813.8200000000002 3666.2 4245.3 2392.1 2385.8 1842.04 1361.47 1168.26 961.9000000000001 True False 1708.8668188234922 1601.4571111779592 3168.3501769950853 3503.9380491506877 2175.734977359557 2361.8010181330787 1703.0934397650879 1325.3593929221768 1982.4518936655668 1085.3692346994385 1.5744566587947495 1.4754952139595483 2.919145002182108 3.228337359424972 2.004603509848023 2.176034608892439 1.569137382299868 1.221113839005393 1.8265230211860108 1.0 10.083970205166292 -7.276917258932538 2.430641445177019 1.3818425163363965 2.2828311319171 0.3641992440182755 0.5385773882655259 0.37744292754906716 4.38706748851426 0.28358237009223836 0.18533136809658798 5.2854593988299175e-08 7.276917258932538 0.9009886155807036 SPQEEDFRCPS(ph)DEDFR ddPTM_A459_Selumetinib_30min_R2 1 SPQEEDFRCPSDEDFR 16 1 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 SPQEEDFRCPS(1)DEDFR 75.017 0.017329 38107000.0 25229.0 25221.0 29561.0 29461.0 25690.0 24374.0 22342.0 20750.0 16798.0 26444.0 True False 23826.87317968897 27155.369601703143 27659.07744358324 25448.36097694029 22462.59252848603 27731.297254857654 23380.947269833137 20810.379064652585 20158.06937533545 25680.493010236678 0.9278199281529048 1.0574317864878433 1.0770462012765045 0.9909607641409433 0.8746947544788981 1.0798584452332551 0.910455545402228 0.8103574591172068 0.7849564791182203 1.0 14.648385278917615 -7.496311870584221 6.299435383452232 0.8499286079158648 1.0009791878702268 0.37065274415287763 0.08057934732707982 0.17157409415182204 24.245628598832624 0.035181102131142325 0.022470577420145535 3.189246807162307e-08 7.496311870584221 0.151050579954362 SPQESALLFIPVHS(ph)PSTEGPQLPPVPAATQEK ddPTM_A459_Selumetinib_30min_R2 1 SPQESALLFIPVHSPSTEGPQLPPVPAATQEK 32 0 Q7RTP6;J3QR21;J3QLA3 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 S(0.002)PQES(0.002)ALLFIPVHS(0.331)PS(0.331)T(0.331)EGPQLPPVPAAT(0.002)QEK 49.62600000000001 0.0079825 2094300.0 4241.0 4377.2 5915.4 5857.8 5763.4 4344.8 5828.7 5062.3 4887.6 5197.7 True False 4005.302198068134 4712.917165083662 5534.809604200547 5059.957534731366 5039.350166550267 4943.256761832507 6099.746099349941 5077.030454891123 5865.256570954253 5047.628895753559 0.7935017174970396 0.9336893148084874 1.096516744496974 1.002442461447231 0.9983598776030749 0.9793225421130192 1.2084379072481934 1.0058248258231302 1.1619825252780653 1.0 12.301390131207471 -4.932669795336374 2.6060434794105065 1.055462683636362 0.7776723544858192 0.5567061105685572 0.07392099684110665 0.2617223949222932 2.9484848290062375 0.019175555908991643 0.13935427090337524 1.167697108156196e-05 4.932669795336374 -0.2777903291505429 SPQESALLFIPVHSPSTEGPQLPPVPAAT(ph)QEKSPEER ddPTM_A459_Selumetinib_30min_R1 1 SPQESALLFIPVHSPSTEGPQLPPVPAATQEKSPEER 37 1 Q7RTP6;J3QR21;J3QLA3 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 SPQESALLFIPVHS(0.01)PS(0.048)T(0.048)EGPQLPPVPAAT(0.687)QEKS(0.207)PEER 84.06700000000002 3.3113e-08 14855000.0 432.72 515.0 342.94 482.02 487.84 614.53 335.2 398.26 299.84 325.74 True False 442.80153407345193 454.7035605829953 296.37063163457907 397.8442556360242 443.7149581351471 608.3483861485963 309.91559412893196 387.69685106920167 508.8065805528591 367.5519019762919 1.2047319893940145 1.237113882796136 0.8063368194832408 1.0824165335476517 1.2072171460665382 1.6551360035890563 0.8431886557042557 1.0548084474181532 1.384312195956691 1.0 8.521804176966585 SPQGPSPVLAEDS(ph)EGEG ddPTM_A459_Selumetinib_30min_R2 1 SPQGPSPVLAEDSEGEG 17 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 1 SPQGPSPVLAEDS(1)EGEG 87.38799999999998 0.010656 3159000.0 8622.1 8252.2 8477.2 9237.0 9024.9 7663.5 6515.1 6712.8 7776.3 7880.6 True False 8142.918199000999 8885.117204994829 7931.786181277488 7978.904665286224 7891.111378370323 8719.077562673414 6818.065059425734 6732.33313663614 9331.77728797601 7653.066601742218 1.0640072304018975 1.160987832377172 1.0364193328033784 1.042576143721241 1.031104495624527 1.1392920010245982 0.890893208465428 0.879690911758631 1.2193513755455407 1.0 12.901822239607192 -7.247421013850977 24.993434062901777 0.9874581082998277 1.0770113108511072 0.14602708277962528 0.09534742591034147 1451.560829890742 2587999.7660137583 0.03631890276950075 0.02798765617646491 5.656906312066492e-08 7.247421013850977 0.08955320255127952 SPQNDDHS(ph)DTDSEENRDNQQFLTTVK ddPTM_A459_Selumetinib_30min_R1 1 SPQNDDHSDTDSEENRDNQQFLTTVK 26 1 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 SPQNDDHS(0.472)DT(0.472)DS(0.056)EENRDNQQFLTTVK 81.477 7.1688e-05 8630100.0 584.1 478.29 548.6 400.94 499.16 477.71 390.24 289.54 188.76 457.12 True False 597.708393539248 422.2915844490113 474.1031332440956 330.9233555759255 454.01106613385565 472.9046711259759 360.8038826159736 281.8604586415325 320.31193351506715 515.7958047258628 1.1588081718829033 0.8187185327601734 0.9191682617427914 0.641578222513473 0.8802147322139529 0.9168447412582527 0.6995091454994192 0.5464574470343682 0.6210053098150107 1.0 9.010656228652516 -1.5228787507930504 0.7493299627315232 0.744258979940247 69.33147104325758 0.38188178804090966 0.14299594876968774 401.4807167500558 1.738152683114736 0.05508580089199703 46477.5646494261 0.029999999619195295 1.5228787507930504 68.58721206331734 SPQNDDHS(ph)DTDSEENRDNQQFLTTVK ddPTM_A459_Selumetinib_30min_R2 1 SPQNDDHSDTDSEENRDNQQFLTTVK 26 1 Q86W56-3;Q86W56-2;Q86W56 Q86W56-3 PARG Poly(ADP-ribose) glycohydrolase 1 SPQNDDHS(0.85)DT(0.141)DS(0.009)EENRDNQQFLTTVK 72.654 0.00024773 8725500.0 49661.0 45300.0 58520.0 66910.0 82405.0 46529.0 46299.0 52936.0 51907.0 55960.0 True False 46901.04042873414 48774.36433754222 54754.886911758425 57796.74257381203 72052.54718995295 52937.94740179177 48451.99523972806 53090.03499597346 62289.850402758464 54344.28939845881 0.8630353059702395 0.8975067091212245 1.0075554859184757 1.0635292725982564 1.3258531482793912 0.9741216232241888 0.8915747316976077 0.9769202170758181 1.1462078369640987 1.0 15.729840821621249 -5.30047858459552 2.6727779964928944 1.0534559265393386 0.8690141714073653 0.2758005146469614 0.1115205587648391 0.4104913430038829 5.675263210499144 0.03325823055947657 0.09863405416536292 5.006352386398485e-06 5.30047858459552 -0.18444175513197336 SPQPPVEEEDEHFDDT(ph)VVCLDTYNCDLHFK ddPTM_A459_Selumetinib_30min_R1 1 SPQPPVEEEDEHFDDTVVCLDTYNCDLHFK 30 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;Q5RI18;A0A1W2PRI6 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.438)PQPPVEEEDEHFDDT(0.562)VVCLDTYNCDLHFK 109.28 4.2819e-11 55878000.0 8406.0 8718.6 4261.4 4750.0 5612.0 5828.5 6645.7 5875.9 4278.7 5976.5 True False 8601.843444771295 7697.822258832826 3682.72528619466 3920.501668543037 5104.395590879072 5769.87058185458 6144.409498516234 5720.052044386889 7260.641396116327 6743.641991039811 1.2755486510405583 1.141493316083627 0.5461033208891944 0.5813626633430654 0.7569197175148408 0.8556015561800185 0.9111411173191327 0.8482140736395923 1.0766647170421335 1.0 12.71931223264712 -9.550469266917737 21.47158324145086 0.9999999999999933 0.8711759754154694 0.017628005662664425 0.21997723779361014 0.0 0.0 0.23092273008792413 0.056006988676971105 2.8153392370773664e-10 9.550469266917737 -0.1288240245845239 SPQPVCS(ph)PAGSEGTPK ddPTM_A459_Selumetinib_30min_R1 2 SPQPVCSPAGSEGTPK 16 0 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 SPQPVCS(0.968)PAGS(0.031)EGT(0.001)PK;SPQPVCS(0.73)PAGS(0.249)EGT(0.02)PK 81.01 0.022248 16109600.0 4109.200000000001 4420.5 5344.0 6050.9 3872.0 4901.6 4521.5 3799.1 2221.0299999999997 3784.9 True False 4204.936364888677 3902.945804965305 4618.314152490789 4994.223904460436 3521.778283657123 4852.294354296714 4180.439614719464 3698.335526784024 3768.9256923869984 4270.728783048034 0.9845945688659723 0.9138828530759003 1.0813878349808677 1.169407882861632 0.8246316876024186 1.136174784396778 0.9788586040193051 0.8659729321758778 0.8825017658220626 1.0 12.06026656574311 -7.56547903032192 7.181915003583441 0.9079804823718869 1.0180212119101628 0.1698304369648561 0.10057506158136244 0.352196188980775 46.85003172727518 0.04708584251955057 0.02715237213394384 2.7196998021871136e-08 7.56547903032192 0.11004072953827593 SPQPVCS(ph)PAGSEGTPK ddPTM_A459_Selumetinib_30min_R2 2 SPQPVCSPAGSEGTPK 16 0 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 S(0.033)PQPVCS(0.927)PAGS(0.039)EGT(0.001)PK;S(0.001)PQPVCS(0.818)PAGS(0.174)EGT(0.007)PK 178.23 1.1228e-06 19442100.0 82401.0 81794.0 91160.0 96138.0 94420.0 66701.0 68171.0 81362.0 67397.0 83691.0 True False 77821.48229733839 88067.33679083729 85294.86484750324 83043.83855269986 82558.11547449023 75888.45729860767 71341.08657827377 81598.74994979573 80878.28322952046 81274.62337466802 0.957512678202014 1.0835772979821208 1.0494649043687634 1.0217683589855093 1.0157920399569917 0.9337288091606324 0.8777781257674782 1.0039880415518325 0.9951234453179749 1.0 16.310517345054343 -6.634684983932032 5.149245143269255 0.9573798817292057 1.0318575433561352 0.3225774657349131 0.045792407191717656 0.23952639557955516 9.881335140693343 0.01588584574816837 0.01583506493036922 2.3190761849735216e-07 6.634684983932032 0.07447766162692948 SPQQTVPYVVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SPQQTVPYVVPLSPK 15 0 Q9UQR0;H0Y6S1;B4DRC2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 S(0.008)PQQT(0.005)VPY(0.011)VVPLS(0.976)PK;S(0.002)PQQT(0.046)VPY(0.01)VVPLS(0.942)PK 114.96 0.0024292 69847000.0 8600.0 9435.7 11120.400000000001 11197.6 7689.0 9209.2 8196.4 9214.7 5916.3 8629.3 True False 8800.363267313016 8330.96385746208 9610.310759984763 9242.149364984743 6993.531307603209 9116.563809284587 7578.138949040498 8970.296222436036 10039.528990544568 9736.95471150001 0.9038106397803396 0.855602609265774 0.9869934743184466 0.9491827413009463 0.7182462602340515 0.9362849144730335 0.7782863506687772 0.9212630117136626 1.0310748368468015 1.0 13.249254916355795 -8.117907841859985 4.4490120481864395 1.0129092902861865 0.8765179543866357 0.344567135309074 0.07599718554738784 0.2640425548733623 8.162660678856268 0.055895855062373184 0.01976401647817448 7.622407418438519e-09 8.117907841859985 -0.13639133589955077 SPQQTVPYVVPLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SPQQTVPYVVPLSPK 15 0 Q9UQR0;H0Y6S1;B4DRC2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 SPQQT(0.001)VPYVVPLS(0.999)PK;SPQQTVPYVVPLS(1)PK 141.3 0.00038604 36423000.0 248788.0 244886.0 227926.0 229005.0 214081.0 166122.0 217250.0 219341.0 152740.0 209838.0 True False 234961.35893727295 263667.9687674035 213261.4893070647 197814.1239443404 187186.23087157722 189003.79759462806 227352.55547270793 219979.24599614274 183292.267912176 203779.4317154001 1.1530180301288786 1.293889017885005 1.046530984564268 0.9707266443877863 0.9185727396325402 0.9274920241145446 1.1156796029848106 1.079496807623683 0.8994640252415826 1.0 17.63664891622666 -5.408105978182455 4.670776177447346 0.9916960724564844 1.2212273553452277 0.6239380442813596 0.07206853255139821 0.14540198525907244 4.904853154168103 0.0201280695939783 0.04349609840614832 3.907455329542927e-06 5.408105978182455 0.22953128288874336 SPQTLAPVGEDAMKTPS(ph)PAAEDAREPEAK ddPTM_A459_Selumetinib_30min_R1 1 SPQTLAPVGEDAMKTPSPAAEDAREPEAK 29 2 Q92797 Q92797 SYMPK Symplekin 1 SPQTLAPVGEDAMKT(0.013)PS(0.987)PAAEDAREPEAK 60.139 0.0014007 9797500.0 1040.0 1008.0 2361.1 2458.4 1145.5 1368.5 1388.3 1229.3 1084.7 682.12 True False 1064.2299765122712 889.9828913935131 2040.4755885939373 2029.0865898834118 1041.889727254451 1354.7341324985834 1283.579413273258 1196.6949706708433 1840.6566766464994 769.6767464114579 1.3826973225761838 1.15630736610268 2.6510812469097633 2.6362841275169457 1.3536718266625039 1.7601338988281743 1.6676863621745373 1.554802033776278 2.3914671779138192 1.0 9.588108850819873 SPQTPSQMVPLPSANPPGPLKS(ph)PQVLGSSLSVR ddPTM_A459_Selumetinib_30min_R2 1 SPQTPSQMVPLPSANPPGPLKSPQVLGSSLSVR 33 1 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 SPQTPSQMVPLPSANPPGPLKS(0.973)PQVLGS(0.024)S(0.002)LS(0.001)VR 91.603 5.046699999999999e-09 7330000.0 22062.0 17873.0 25935.0 29214.0 23932.0 19121.0 21234.0 23136.0 20940.0 28208.0 True False 20835.882361183474 19243.801629247053 24266.37033589296 25235.002803039057 20925.44820520546 21754.74418684391 22221.423074372786 23203.321929629004 25128.58511248507 27393.56174681426 0.7606123859963769 0.7024935934621578 0.8858421026143132 0.9212019611131352 0.7638819806861731 0.794155370809854 0.8111914500113163 0.8470355970532908 0.9173171909785482 1.0 14.741549238889315 -14.522878745280329 0.1065914320194294 1.6033819132662765 0.7086191090524804 0.5174007318822171 0.05986362358166736 160.47956057681827 1.1422409906289042 20.976573289806513 0.9130950800572382 3.0000000000000626e-15 14.522878745280329 -0.8947628042137962 SPRPAS(ph)PASNVVVLPSGSTVYVK ddPTM_A459_Selumetinib_30min_R1 2 SPRPASPASNVVVLPSGSTVYVK 23 1 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 S(0.128)PRPAS(0.868)PAS(0.005)NVVVLPSGSTVYVK;S(0.223)PRPAS(0.707)PAS(0.071)NVVVLPSGSTVYVK 109.74 9.0687e-06 35437000.0 5826.4 6754.9 9036.8 9330.4 7677.5 7053.5 6793.8 6315.700000000001 3737.0 5839.8 True False 5962.143783799129 5964.033167732183 7809.652195589212 7701.020793299785 6983.071480572715 6982.548194065585 6281.338196280237 6148.187119715157 6341.416060318957 6589.395214469053 0.9048089528318776 0.9050956838400444 1.185184973947337 1.1686991814347112 1.0597439147737298 1.0596645013389459 0.95324957630218 0.9330427026466576 0.9623669326123312 1.0 12.685930343047799 -7.2626343940965326 24.260575598204102 0.9565850220780232 1.0531052466052107 0.18049795496849175 0.08790698888574902 128.64602462964075 2611644.1743696514 0.039563645731308855 0.028389545743598414 5.462174946228354e-08 7.2626343940965326 0.09652022452718745 SPRPAS(ph)PASNVVVLPSGSTVYVK ddPTM_A459_Selumetinib_30min_R2 2 SPRPASPASNVVVLPSGSTVYVK 23 1 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 S(0.284)PRPAS(0.701)PAS(0.015)NVVVLPSGSTVYVK;S(0.044)PRPAS(0.941)PAS(0.014)NVVVLPSGSTVYVK 120.64 5.824500000000002e-06 15622200.0 99732.0 86872.0 116228.0 107002.0 125840.0 74603.0 73166.0 81074.0 65008.0 101254.0 True False 94189.29469882826 93534.80306249388 108750.01701947821 92428.14301125448 110030.85417612625 84878.88607139351 76568.36397567861 81309.91191747681 78011.4164752832 98330.53393051353 0.9578845037634829 0.951228467126919 1.1059638616050609 0.9399739767158181 1.1189896950410225 0.8631996865935276 0.7786834965198763 0.8269040008969691 0.7933590244756621 1.0 16.58535185623704 -6.900311386979961 7.336391390619973 0.83339609163857 1.011715064337463 0.5012312112261068 0.08034827105469945 0.17100035553750945 11.015281629142956 0.026886193797799603 0.023710866261721135 1.2580230920636426e-07 6.900311386979961 0.17831897269889307 SPRPGS(ph)SAPEHSPR ddPTM_A459_Selumetinib_30min_R2 2 SPRPGSSAPEHSPR 14 1 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 S(0.122)PRPGS(0.782)S(0.096)APEHSPR;S(0.017)PRPGS(0.767)S(0.207)APEHS(0.009)PR 70.80199999999998 0.031111 1934800.0 1408.75 650.96 1876.9099999999999 1921.17 1694.19 1694.6399999999999 1422.21 3621.2 1867.42 1835.04 True False 1330.4573146730681 700.8865388336975 1756.151654025094 1659.5033317968969 1481.3507059492315 1928.0612775897264 1488.3455830556518 3631.7370924780685 2240.956180074348 1782.0576271934924 0.7465848995962966 0.3933018372349171 0.9854628869610705 0.9312287697510644 0.8312585874577832 1.0819298142598064 0.8351837563185885 2.0379459323083617 1.2575105012757422 1.0 10.799328275350213 -7.7121024558609 22.073687566787996 1.4857946212899955 0.8322286938133668 0.4588969257164769 0.2980964421656893 26.718142972079324 11953.598031370873 0.13717744092514492 0.07919861859871544 1.9404280507325768e-08 7.7121024558609 -0.6535659274766287 SPRPGSS(ph)APEHSPR ddPTM_A459_Selumetinib_30min_R2 1 SPRPGSSAPEHSPR 14 1 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 S(0.015)PRPGS(0.179)S(0.765)APEHS(0.041)PR 68.26100000000001 0.03514 756920.0 3306.9 2276.7 879.61 3181.2 2773.1 2116.0 2053.8 2950.7 977.06 3180.5 True False 3123.1157365695626 2451.315569255681 823.0168502469561 2747.915072123906 2424.718386171453 2407.4597928644803 2149.3057695274933 2959.28604848532 1172.4993013373767 3088.6707010685905 1.0111520582265552 0.7936474316953235 0.2664631260180038 0.8896756365685754 0.7850362245909125 0.7794485155156129 0.6958675681366407 0.958109923295317 0.3796129192185253 1.0 11.592770350752385 SPRPGSSAPEHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SPRPGSSAPEHSPR 14 1 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 SPRPGSSAPEHS(1)PR 84.40299999999998 0.014252 1375000.0 1122.3 830.21 2794.9 1101.5 673.07 737.61 991.45 1188.4 2180.8 1262.0 True False 1059.9270589228634 893.8844374541038 2615.0791768570334 951.4737998065144 588.5129292778553 839.2090821430852 1037.5543895209046 1191.8580472497886 2617.0209366431436 1225.5627809302187 0.8648492557177401 0.7293665011396915 2.133778226254679 0.776356637629231 0.4801981085221648 0.6847540535672225 0.8465942387165077 0.9724985662057657 2.135362608398396 1.0 10.259228674551682 -8.107004082543114 11.22092389680187 1.5669398124117704 0.9347022538058016 0.20831491937049973 0.49307714744457976 0.888199436424112 88.63208070962393 0.339252995012345 0.12811435804884871 7.816204570065723e-09 8.107004082543114 -0.6322375586059688 SPRPT(ph)SAPAITQGQVAEGGVLDASAK ddPTM_A459_Selumetinib_30min_R2 1 SPRPTSAPAITQGQVAEGGVLDASAK 26 1 P11171;Q4VB86;A0A2U3TZH6;A0A3B3IU06;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8YCW8;A0A2R8Y6G5;A0A2R8YFR9;A0A2R8Y4N6;A0A2R8YD30;A0A3B3IUD6;A0A2R8Y7Y3;A0A2R8Y7N0;A0A2R8Y420;A0A3B3ITP0;P11171-3;P11171-4;P11171-7;P11171-6;P11171-5;P11171-2;A0A2R8Y6D0;A0A1B0GWG0;A0A2R8Y5C8 P11171 EPB41 Protein 4.1 1 S(0.108)PRPT(0.418)S(0.418)APAIT(0.056)QGQVAEGGVLDASAK 81.455 0.00018078 7471700.0 32961.0 23927.0 25171.0 30028.0 32659.0 32146.0 33276.0 27808.0 31064.0 25118.0 True False 31129.159573337343 25762.123962568923 23551.52526411265 25938.134598810724 28556.08444483556 36573.819707666145 34823.39993514308 27888.916676137782 37277.66800067985 24392.778075598442 1.2761629477733702 1.0561373486335417 0.9655122180475479 1.063353035001708 1.1706778275247756 1.4993708217373212 1.4276110669812971 1.1433267908109548 1.5282256037073094 1.0 14.57416645452041 -6.554803755451227 8.49942969465403 1.3358234162361677 1.0835280382492964 0.29987255902007004 0.1655993103540273 0.2782260118180661 66.05596410532947 0.0527133579717422 0.05297437928679665 2.7873804170553615e-07 6.554803755451227 -0.2522953779868713 SPRS(ph)PQLSDFGLER ddPTM_A459_Selumetinib_30min_R1 2 SPRSPQLSDFGLER 14 1 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 S(0.038)PRS(0.962)PQLSDFGLER;S(0.152)PRS(0.848)PQLSDFGLER 93.649 0.0077918000000000015 12659000.0 1324.95 1685.8600000000001 3113.2 3762.9 1856.54 1695.1799999999998 1305.87 1418.83 1007.8600000000001 1286.19 True False 1355.8187570960895 1488.4787274649498 2690.444539583518 3105.7801533811785 1688.6162847987594 1678.1280283002902 1207.367174538032 1381.1980193906384 1710.2648088180526 1451.2850150515337 0.9342194972280794 1.0256281240608658 1.8538360912435816 2.1400208237324736 1.1635318130386665 1.1563049372770526 0.8319297464083302 0.9517069390684733 1.1784486100804417 1.0 10.50311515997467 -6.50678794733497 24.264738971894108 1.0254801013335384 1.502758163156719 0.2932666399589968 0.3412208458338396 686.4321364861557 1035133.5711276474 0.11941880054131043 0.1315615342152181 3.1132360636683506e-07 6.50678794733497 0.47727806182318067 SPS(ph)AGDVHILTGFAK ddPTM_A459_Selumetinib_30min_R1 2 SPSAGDVHILTGFAK 15 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 S(0.008)PS(0.992)AGDVHILTGFAK;S(0.415)PS(0.585)AGDVHILTGFAK 119.54 0.0018956 15904800.0 4822.54 7306.4 4597.0 4787.7 5872.799999999999 4893.5 6509.6 6697.200000000001 3084.85 6260.8 True False 4934.895798970661 6450.96329134679 3972.7526495135044 3951.6180712596824 5341.606276927052 4844.275832942506 6018.575631090973 6519.56850042851 5234.765141470415 7064.434665356323 0.6985549492263228 0.9131605849484362 0.5623595995580097 0.5593679124301685 0.7561265026799744 0.6857273175302507 0.8519543199409576 0.9228719365755036 0.7410026972351338 1.0 12.786358397504301 -7.305714905578905 4.700931087130959 0.8756538113734464 0.6958284695467865 0.39530747591356286 0.11111896285069403 0.24514895818297344 12.623082388167827 0.04890474169305431 0.033084472684049834 4.946352858261445e-08 7.305714905578905 -0.17982534182666 SPS(ph)AGDVHILTGFAK ddPTM_A459_Selumetinib_30min_R2 2 SPSAGDVHILTGFAK 15 0 A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2-4;Q9Y2H2 A0A3B3ITL0 INPP5F Phosphatidylinositide phosphatase SAC2 1 S(0.149)PS(0.851)AGDVHILTGFAK;S(0.151)PS(0.849)AGDVHILTGFAK 145.1 0.00036945 10810900.0 69851.0 57384.0 78560.0 75867.0 85056.0 71287.0 90774.0 79040.0 76320.0 65808.0 True False 65968.96105570784 61785.16828135812 73505.53512966061 65533.783722125096 74370.50486971236 81106.1371710446 94995.17086526875 79269.99331422367 91586.13255897151 63907.95205028195 1.0322496487417452 0.9667837303368186 1.1501782293356453 1.025440209233492 1.1637128476781513 1.2691086878708198 1.4864374122101078 1.2403776176688477 1.4330944682269389 1.0 15.963707836069515 -6.5979461751902315 2.39075935324689 1.3164818726691971 1.0455469484575979 0.43030327588593 0.12945672006448802 0.2483895423817955 2.883895172830335 0.044558100797423617 0.04558060354258541 2.523793542491276e-07 6.5979461751902315 -0.27093492421159926 SPS(ph)ASSLSSMSSVASSVSSR ddPTM_A459_Selumetinib_30min_R2 1 SPSASSLSSMSSVASSVSSR 20 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0;F5H0N7 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 S(0.309)PS(0.69)ASSLSSMSSVASSVSSR 132.23 0.00014666 7071200.0 5375.7 4053.8 9041.0 8232.9 9170.6 3058.6 6339.7 7683.0 8735.2 5665.0 True False 5076.94011463213 4364.713424978556 8459.311903096515 7111.564817455335 8018.507241795796 3479.894386793619 6634.508611877228 7705.356258010878 10482.484081880599 5501.436730562352 0.9228389534006637 0.7933770101782847 1.5376550376562836 1.2926741078286286 1.4575296662506836 0.6325428351218915 1.2059592678800206 1.4006079930366198 1.9054084587843818 1.0 12.425592720277011 -7.782092259964388 3.9711496674366984 1.505187365784402 1.121672996665645 0.15428039822041228 0.3352252137606866 0.36736732248927895 12.647630077772705 0.19187277688956358 0.09209529124594117 1.6516108986540463e-08 7.782092259964388 -0.383514369118757 SPS(ph)ASSLSSMSSVASSVSSRPSR ddPTM_A459_Selumetinib_30min_R2 1 SPSASSLSSMSSVASSVSSRPSR 23 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0;F5H0N7 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 S(0.241)PS(0.757)AS(0.001)SLSSMSSVASSVSSRPSR 70.987 0.0012179 11183000.0 0.0 0.0 0.0 1583.9 1625.3 0.0 1344.9 1504.7 0.0 1088.4 True False 0.0 0.0 0.0 1368.1700876200978 1421.115283633645 0.0 1407.4405148687924 1509.0784278835047 0.0 1056.9750639971871 0.0 0.0 0.0 1.2944204023565675 1.3445116465277624 0.0 1.331574000947801 1.4277332354242944 0.0 1.0 10.04572562593145 -5.746813965951997 24.680188693982878 0.929105664613449 5.686539228844658e-07 0.41725115936804136 0.49478563694595473 197.57477524647695 333401.45894147473 0.13353948870157034 0.22996312357925228 1.79137304087655e-06 5.746813965951997 -0.9291050959595262 SPS(ph)ASSVGSR ddPTM_A459_Selumetinib_30min_R2 1 SPSASSVGSR 10 0 O15164-2;O15164 O15164-2 TRIM24 Transcription intermediary factor 1-alpha 1 S(0.068)PS(0.733)AS(0.152)S(0.047)VGSR 80.737 0.046835 2351400.0 7256.6 8731.3 7474.5 6900.2 12795.0 7275.3 7302.6 6443.4 6961.6 8681.0 True False 6853.307222471406 9400.962634445528 6993.598807620277 5960.3808564910705 11187.57771124869 8277.406536402148 7642.185369827379 6462.149227237709 8354.114523356067 8430.356974053264 0.8129320316523178 1.115132213663024 0.829573270639072 0.7070140534778987 1.327058598548262 0.9818571813599516 0.9065079205243978 0.7665332852602501 0.9909562013884046 1.0 13.041378006433545 -1.536044046882262 24.95214284858052 0.942954744250378 0.004715386115525577 0.0 0.17382023145409523 0.0 0.0 0.03982222598649687 0.0 0.029104219231741477 1.536044046882262 -0.9382393581348524 SPS(ph)DEYKDNLHQVSK ddPTM_A459_Selumetinib_30min_R2 2 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 S(0.089)PS(0.882)DEY(0.028)KDNLHQVSK;S(0.092)PS(0.499)DEY(0.409)KDNLHQVSK 63.16 0.031387 9289300.0 66667.0 59099.0 66758.0 74832.0 70618.0 47728.0 66710.0 63052.0 50992.0 73986.0 True False 62961.915029145945 63631.703266763994 62462.8629606146 64639.75250759975 61746.33550706992 54302.09876835347 69812.14718335726 63235.470881179484 61191.82483552237 71849.83194128615 0.8762987097951297 0.885620766917899 0.8693529445087312 0.8996507126199225 0.8593803748563734 0.7557721055315447 0.9716396725938895 0.8801060374484091 0.8516627413342702 1.0 16.132697161733013 -11.029578463377407 2.754133594341759 1.005562667210077 0.8726463170665701 0.36987159750380727 0.05005294170608608 23035539.718336657 24199874.36427699 967861.0948029123 0.013265874411533323 9.34160579523329e-12 11.029578463377407 -0.1329163501435069 SPS(ph)FGGASEASAR ddPTM_A459_Selumetinib_30min_R2 1 SPSFGGASEASAR 13 0 H7C2F7;Q8WVT3 H7C2F7 TRAPPC12 Trafficking protein particle complex subunit 12 1 S(0.39)PS(0.609)FGGAS(0.001)EASAR 126.32 0.0020397 5226200.0 6063.2 6532.2 9306.2 9903.5 10233.0 6655.9 5366.8 7577.1 5103.2 6350.0 True False 5726.231616912687 7033.198735666514 8707.449223824438 8554.626215509594 8947.439055819295 7572.689808755521 5616.366834112449 7599.148106543568 6123.982595321579 6166.6590007186105 0.9285792543815704 1.1405201317029081 1.412020548373073 1.387238408109271 1.4509378668054511 1.2280052793373306 0.9107633215097455 1.2322958194474556 0.9930794932244416 1.0 12.590273356116024 -7.066770417942122 8.353239020623556 1.0548633735166533 1.2787248422840125 0.3130357716947998 0.1612433035781502 0.4875251042407925 56.86623827921317 0.065685791687911 0.0509755031738584 8.574910228242086e-08 7.066770417942122 0.22386146876735924 SPS(ph)GAGEGASCSDGPR ddPTM_A459_Selumetinib_30min_R1 1 SPSGAGEGASCSDGPR 16 0 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 S(0.042)PS(0.958)GAGEGASCSDGPR 128.82 0.00092192 3527700.0 666.92 567.77 712.74 611.71 703.28 698.92 784.06 785.02 427.26 661.85 True False 682.457938399581 501.29522445088804 615.9538228005774 504.8863317188343 639.6684481741685 691.8894993685855 724.9177229496723 764.1987194956685 725.0290141642704 746.8048944649377 0.9138369920413294 0.6712532659685504 0.8247854658771205 0.6760618944263476 0.8565402462077741 0.9264662089076192 0.9706922495052114 1.0232909896006948 0.9708412726509124 1.0 9.544587572610872 -6.753101633724281 2.043234978960451 0.9909743474893487 0.7678298202991122 0.6764716791208489 0.068104681633603 0.1745500078389454 1.5003090068477893 0.02548055833565544 0.02355208008940951 1.7656245803434492e-07 6.753101633724281 -0.22314452719023647 SPS(ph)GAGEGASCSDGPR ddPTM_A459_Selumetinib_30min_R2 1 SPSGAGEGASCSDGPR 16 0 Q7Z2K8;Q7Z2K8-2 Q7Z2K8 GPRIN1 G protein-regulated inducer of neurite outgrowth 1 1 S(0.177)PS(0.823)GAGEGASCSDGPR 152.94 0.00015728 2411800.0 2544.4 2742.3 1810.0 2534.7 2071.2 1148.8 2965.9 3094.2 1144.1 2478.0 True False 2402.9924340402163 2952.625592115718 1693.5465705789945 2189.469487398612 1810.9973392370673 1307.0367722319072 3103.8202268193563 3103.203609727613 1372.9519688249363 2406.453701382791 0.9985616729959998 1.2269613125816992 0.7037519855901871 0.9098323753914332 0.7525585629162265 0.5431381337113864 1.2897901277036188 1.289533892941492 0.5705291433764188 1.0 11.232692951709735 -9.236284635048365 18.36581839491362 0.9999999997731159 0.9285158238947373 0.007112595330664773 0.26708211076984706 0.0 0.0 0.2648811713510566 0.06424312045398455 5.803839113064318e-10 9.236284635048365 -0.07148417587837863 SPS(ph)LGSDLTFATR ddPTM_A459_Selumetinib_30min_R1 1 SPSLGSDLTFATR 13 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 1 S(0.373)PS(0.572)LGS(0.052)DLT(0.003)FATR 123.95 0.0023548 74390000.0 1027.8 1058.2 963.99 1072.8 1112.9 1213.1 1231.9 1084.7 659.68 842.86 True False 1051.7457402493385 934.3054520561664 833.0854528180382 885.4556189500986 1012.2383914984537 1200.897315406673 1138.9767911916197 1055.9302323978384 1119.4287788791034 951.0492911516463 1.105879316702667 0.9823943519528788 0.8759645378729392 0.9310302075698738 1.064338516327279 1.262707755086469 1.1976001683492217 1.110279185550088 1.1770460156944786 1.0 9.893376305053206 -6.518136129091977 5.980656808727906 1.1604026983632767 0.9702637246199555 0.4945888414582875 0.08331777869615703 0.12514656246500033 18.021353509621242 0.02746760094197289 0.029070414627873326 3.032940363613497e-07 6.518136129091977 -0.19013897374332123 SPS(ph)LNLLQNK ddPTM_A459_Selumetinib_30min_R2 1 SPSLNLLQNK 10 0 O43353-2;O43353 O43353-2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1 S(0.025)PS(0.975)LNLLQNK 115.92 0.0064967 10117000.0 33433.0 30131.0 30160.0 28786.0 31272.0 21497.0 29579.0 29477.0 27554.0 24304.0 True False 31574.927702903053 32441.950813564796 28219.53843572514 24865.29714138024 27343.331784772883 24458.01661966338 30954.482109676588 29562.773189819938 33065.56992308564 23602.280370624438 1.3377914001140936 1.3745261179907968 1.1956276254919576 1.0535124890867649 1.1585038121487865 1.0362565072358008 1.311503872659811 1.2525388532632622 1.400948103482377 1.0 14.526638634071217 -14.522858206542967 0.017904097145904838 4.262117281753369e-05 2.0989180199900352 0.13342540314975226 0.1295128454152377 11659.028575705148 15.75876664943237 1208.0459172134879 702.6069472588681 3.000141879926375e-15 14.522858206542967 2.0988753988172175 SPS(ph)MAVPSPGWVASPK ddPTM_A459_Selumetinib_30min_R2 1 SPSMAVPSPGWVASPK 16 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 S(0.344)PS(0.5)MAVPS(0.156)PGWVASPK 99.069 0.010896 0.0 9597.0 9713.4 10023.0 13765.0 9774.4 8132.2 10178.0 9417.3 7310.3 10046.0 True False 9063.637159834916 10458.386546496307 9378.131092217269 11890.183254050547 8546.452487755309 9252.336733238437 10651.297167324386 9444.702783882065 8772.56426684812 9755.945877357342 0.9290372531556155 1.0720012880318726 0.961273382418311 1.2187627323401389 0.8760250000556935 0.9483792601507008 1.0917749340989142 0.9680970869059817 0.8992018177559225 1.0 13.252066039240962 SPS(ph)MPENLNRPR ddPTM_A459_Selumetinib_30min_R1 3 SPSMPENLNRPR 12 1 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;H0Y999 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 SPS(1)MPENLNRPR;S(0.034)PS(0.966)MPENLNRPR;SPS(1)MPENLNRPR 146.67 0.00053869 80070000.0 6703.300000000001 6967.799999999999 7408.6 7829.3 7139.700000000001 7407.2 6983.8 6081.700000000001 3747.8 5460.200000000001 True False 6859.473847648758 6152.006736757665 6402.552812526812 6462.0597291629465 6493.915395616415 7332.690293199492 6457.006343310363 5920.393559854282 6359.742871518162 6161.0698568519365 1.1133575835080174 0.99852896975609 1.0391949712120718 1.0488535074758598 1.054023983901807 1.190165095278794 1.0480332950825586 0.9609359571325117 1.032246512258788 1.0 12.588965178302427 -7.546077173300598 14.077024673172248 0.9988350950908399 1.0712968018182247 0.311868578930693 0.050577214642465784 2.4684201064609144 1493.0945531040286 0.02482666533981027 0.014363012660986909 2.8439556970442398e-08 7.546077173300598 0.07246170672738483 SPS(ph)MPENLNRPR ddPTM_A459_Selumetinib_30min_R2 3 SPSMPENLNRPR 12 1 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;H0Y999 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 S(0.216)PS(0.784)MPENLNRPR;S(0.052)PS(0.948)MPENLNRPR;S(0.002)PS(0.998)MPENLNRPR 93.478 0.011133 115536500.0 135594.0 121317.0 143197.0 160842.0 172252.0 137256.0 123646.0 132417.0 122978.0 143850.0 True False 128058.22830578875 130621.62380436204 133983.86092110485 138935.04213207372 150612.16380758194 156161.76811408662 129395.78399990102 132802.3115471855 147577.03629241587 139696.67673281438 0.9166877215748985 0.9350374458383903 0.9591055711179448 0.9945479404481656 1.0781370561566375 1.1178631572801376 0.9262624353432904 0.9506476077536539 1.056410501265349 1.0 17.091938175083143 -5.678556944611829 2.4133518684641992 1.0198174872994845 0.928059999920407 0.3398309483437021 0.053581729519388555 0.37513586882382793 4.423017858477531 0.017284269619447956 0.03440444852921058 2.0962499023734055e-06 5.678556944611829 -0.09175748737907752 SPS(ph)PAHLPDDPK ddPTM_A459_Selumetinib_30min_R1 5 SPSPAHLPDDPK 12 0 Q92615;H0Y4V9;A0A087X183;H0Y641 Q92615 LARP4B La-related protein 4B 1 S(0.087)PS(0.913)PAHLPDDPK;S(0.432)PS(0.568)PAHLPDDPK;S(0.041)PS(0.959)PAHLPDDPK;S(0.01)PS(0.99)PAHLPDDPK;S(0.008)PS(0.992)PAHLPDDPK 171.99 0.000243 248839900.0 20859.7 22718.5 20437.5 22760.5 21611.999999999996 19450.8 21742.199999999997 20090.0 9668.000000000002 17531.899999999998 True False 21345.69042408944 20058.60745845588 17662.199755151672 18785.805942499745 19657.198415908493 19255.142611913354 20102.16834925435 19557.14793848307 16405.88987721801 19782.29014016747 1.0790302979505655 1.0139679135393609 0.8928288701665028 0.9496274601875144 0.9936765802456318 0.9733525529896179 1.0161699280932783 0.988619002143374 0.8293220734795634 1.0 14.27192183206757 -4.974076549830208 4.563866314246491 0.9584969768016207 1.0704355975963646 0.34519438606492603 0.05355277014260676 0.22059088840990654 11.271150423358568 0.013617290597202411 0.05670343175578145 1.0615084365794526e-05 4.974076549830208 0.11193862079474393 SPS(ph)PAHLPDDPK ddPTM_A459_Selumetinib_30min_R2 5 SPSPAHLPDDPK 12 0 Q92615;H0Y4V9;A0A087X183;H0Y641 Q92615 LARP4B La-related protein 4B 1 S(0.491)PS(0.509)PAHLPDDPK;S(0.245)PS(0.755)PAHLPDDPK;S(0.028)PS(0.972)PAHLPDDPK;S(0.117)PS(0.883)PAHLPDDPK;S(0.051)PS(0.949)PAHLPDDPK 151.7 0.00051553 610979000.0 765050.0 670692.0 723969.0 783170.0 752757.0 577930.0 638024.0 627707.0 481676.0 637836.0 True False 722531.5837378036 722131.9197853187 677389.6227378487 676500.8949563954 658188.9359270368 657534.6115738045 667693.3802205714 629533.5234475117 578024.6591519284 619420.0173830481 1.166464698364747 1.1658194755090612 1.093586909896314 1.092152135822967 1.0625890630848214 1.0615327130559722 1.077933165675644 1.0163273800985502 0.9331707773894545 1.0 19.240558480814933 -5.645136198876826 0.3110151126440183 0.9714257850819704 1.2563348118238054 0.8020770804136325 0.030217454790692464 1.994095778799003 0.23755966960880742 0.03769870260079395 0.20691468729363763 2.2639342049695224e-06 5.645136198876826 0.28490902674183494 SPS(ph)PAHLPDDPKVAEK ddPTM_A459_Selumetinib_30min_R1 2 SPSPAHLPDDPKVAEK 16 1 Q92615;H0Y4V9;A0A087X183;H0Y641 Q92615 LARP4B La-related protein 4B 1 S(0.147)PS(0.853)PAHLPDDPKVAEK;S(0.162)PS(0.838)PAHLPDDPKVAEK 113.14 0.0012782 13966000.0 6088.7 3244.4 23952.8 22467.3 11996.2 8712.9 5399.7 5932.1 4882.0 3278.6 True False 6230.55486345218 2864.54413971936 20700.141323312393 18543.807818454105 10911.145828101126 8625.25613668024 4992.396281676592 5774.761437823567 8284.397432827704 3699.440246268407 1.6841885389923208 0.7743182614204407 5.595479301008428 5.012598280823452 2.949404531971317 2.3315030281622904 1.3495004512405298 1.560982487458344 2.239365115083046 1.0 11.85309128107282 -6.898697134878693 2.7970437509379664 1.599795401147681 3.3133413781953776 0.2526692839303113 1.346682672862605 0.43584814580506787 6.894357214028957 0.5833172740295872 0.5003105375213491 1.2627078055852588e-07 6.898697134878693 1.7135459770476966 SPS(ph)PEPIYNSEGK ddPTM_A459_Selumetinib_30min_R1 2 SPSPEPIYNSEGK 13 0 Q15637-6;Q15637-4;Q15637-7;Q15637-3;Q15637-2;Q15637;Q15637-5 Q15637-6;Q15637-5 SF1 Splicing factor 1 1 S(0.078)PS(0.922)PEPIYNSEGK;S(0.321)PS(0.679)PEPIYNSEGK 182.72 0.00011855 98719000.0 6967.6 9331.2 5934.4 6517.9 6084.5 7345.6 8134.200000000001 7060.5 3565.2 6591.299999999999 True False 7129.931523410487 8238.69876604281 5128.541075325848 5379.671121136139 5534.158049305724 7271.709933271163 7520.630745118014 6873.232604263799 6049.884008094495 7437.357559698934 0.958664615245298 1.1077454189759721 0.6895649475179264 0.7233309785033261 0.7441027280030016 0.9777276236757297 1.0111966091115903 0.9241498138408756 0.8134453614113176 1.0 12.860574417733552 -6.7892239018307 24.94704958572302 0.9446815592853856 0.8439369919059068 0.1385721413250034 0.12542794352457654 505.9459099129844 454272.9177080144 0.04906307932893341 0.04327889145699415 1.6247109151782736e-07 6.7892239018307 -0.10074456737947879 SPS(ph)PEPIYNSEGK ddPTM_A459_Selumetinib_30min_R2 4 SPSPEPIYNSEGK 13 0 Q15637-6;Q15637-4;Q15637-7;Q15637-3;Q15637-2;Q15637;Q15637-5 Q15637-6;Q15637-5 SF1 Splicing factor 1 1 S(0.122)PS(0.878)PEPIYNSEGK;S(0.024)PS(0.976)PEPIYNSEGK;S(0.188)PS(0.812)PEPIYNSEGK;S(0.083)PS(0.917)PEPIYNSEGK 200.97 0.00010371 173964000.0 370928.0 304185.0 340617.0 367078.0 357323.0 337477.0 355679.0 375138.0 295086.0 318707.0 True False 350313.3067024322 327515.01139106596 318702.0730557486 317081.3431551303 312432.89023184974 383961.3934388121 372218.77826456795 376229.5894725613 354111.4453917269 309505.10080976837 1.1318498654332223 1.058189382127072 1.0297150910337758 1.0244785702256278 1.0094595837497389 1.2405656399013822 1.2026256668814819 1.215584455597725 1.1441215167868106 1.0 18.23960366045896 -6.754625017636898 24.999991997621564 1.1766813754867373 1.0485255768558095 0.37514985244408405 0.0693100331999111 145.56949593464503 534053.6394895682 0.02238332945597294 0.021896377496282537 1.759442111296984e-07 6.754625017636898 -0.12815579863092785 SPS(ph)PFTHTHLAQGYR ddPTM_A459_Selumetinib_30min_R1 1 SPSPFTHTHLAQGYR 15 0 P38398-8;P38398-4;P38398;P38398-7;Q5YLB2 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 S(0.003)PS(0.908)PFT(0.089)HTHLAQGYR 128.82 0.00061972 8817100.0 672.31 684.04 771.34 887.82 739.97 581.62 694.31 580.86 455.56 415.95 True False 687.9735149124664 603.9522787984312 666.5962646673365 732.7789034454488 673.0398441523141 575.7694308687069 641.9376377078122 565.4537059008098 773.0520472140499 469.341234196103 1.4658279835370551 1.2868084770623076 1.4202806318713843 1.5612924031713664 1.4340096184071918 1.2267608062498412 1.3677418281974216 1.204781648621456 1.6471002138521855 1.0 8.874493404364141 -6.734984429011907 24.075891321720825 1.306979822506809 1.4318355966029326 0.15783091895990675 0.1641876181062151 318.1243754160317 289514.31837346306 0.05187455092051236 0.05185642238721527 1.8408380008172e-07 6.734984429011907 0.12485577409612358 SPS(ph)PGLFR ddPTM_A459_Selumetinib_30min_R2 1 SPSPGLFR 8 0 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 S(0.371)PS(0.629)PGLFR 86.898 0.033227 4005800.0 49073.0 43214.0 36394.0 37064.0 47203.0 28477.0 35052.0 35695.0 19543.0 21659.0 True False 46345.71911478369 46528.374845089376 34052.449662791114 32015.81926103374 41272.93713982588 32399.448261532045 36681.98745422035 35798.866540374656 23452.14607704373 21033.648393159743 2.203408474292818 2.2120924518363947 1.6189511693969914 1.5221239160508861 1.9622338630157983 1.540362739545866 1.7439669413771093 1.7019808390453386 1.1149823196944995 1.0 14.360411494107984 -1.5228787456195794 0.07666620472814949 0.3147189079004418 5.142262344097984 0.6886610154037228 0.21377669773716995 132.4467972230974 0.7464140333464566 7.4518552291363385 68.08247564436178 0.029999999976566008 1.5228787456195794 4.8275434361975424 SPS(ph)PISISSSETSSIMQK ddPTM_A459_Selumetinib_30min_R2 2 SPSPISISSSETSSIMQK 18 0 Q5VT06 Q5VT06 CEP350 Centrosome-associated protein 350 1 S(0.233)PS(0.767)PISISSSETSSIMQK;S(0.07)PS(0.925)PIS(0.005)ISSSETSSIMQK 116.96 0.0010296 5688000.0 18959.8 20613.2 21480.3 21937.2 22624.7 14875.8 16729.4 17466.0 16510.2 19924.7 True False 17906.090218092948 22194.16615811534 20098.280883982305 18949.31551621922 19782.382918615735 16924.806420932622 17507.350248677212 17516.823168348037 19812.70133353156 19349.422140412305 0.925406975368795 1.1470195852392735 1.0387018660369174 0.9793220375632076 1.0223759022394352 0.8746931199347941 0.9047996431951408 0.9052892143876077 1.0239427921804276 1.0 14.240002861288128 -6.309128839484322 1.7440559515194245 0.9366157900954999 1.0418602959201715 0.21737036964515222 0.0689407165546828 0.4551409943343017 2.736973606785394 0.024494408303105158 0.03141546512932927 4.907622631194411e-07 6.309128839484322 0.1052445058246716 SPS(ph)PISNQPSPR ddPTM_A459_Selumetinib_30min_R2 3 SPSPISNQPSPR 12 0 F6SS63;Q8N5C8-2;Q8N5C8 F6SS63 TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 1 S(0.018)PS(0.978)PIS(0.001)NQPS(0.004)PR;S(0.116)PS(0.829)PIS(0.055)NQPSPR;S(0.007)PS(0.977)PIS(0.015)NQPS(0.001)PR 129.17 0.0023473 22891300.0 29149.0 29389.9 32436.0 30805.2 29698.199999999997 22334.0 22705.4 22691.5 23250.8 28359.8 True False 27529.0152726923 31644.01082657687 30349.10307364658 26609.47861806594 25967.246610723403 25410.305772133877 23761.24608989658 22757.52850821995 27901.60968163169 27540.978886390483 0.9995656068091285 1.1489791614565277 1.1019616695121808 0.9661776630319828 0.9428585206735427 0.9226362605684474 0.862759678510858 0.8263151648348165 1.013094334690457 1.0 14.74929221750611 -5.903226117427311 3.003279451376179 0.9169400021448096 1.0908932555190403 0.5401212787760421 0.06343728658762718 0.17719447226532412 3.2118794130991266 0.01880228054920558 0.029784106607792613 1.2496082465121736e-06 5.903226117427311 0.17395325337423062 SPS(ph)PLGTSVR ddPTM_A459_Selumetinib_30min_R1 1 SPSPLGTSVR 10 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 S(0.218)PS(0.782)PLGTSVR 139.31 0.0015418 39036000.0 2261.6 2505.8 2083.7 1933.6 2063.2 2031.7 2409.9 2018.1 1220.4 1716.4 True False 2314.2908796924553 2212.419771085186 1800.744984944808 1595.93305816733 1876.583924287546 2011.2629426360045 2228.119302778379 1964.57343228734 2070.929665510638 1936.7166591518 1.194955838664607 1.1423559355626818 0.9297926862122713 0.8240405485365532 0.968951196562439 1.0384910632807034 1.150462197064077 1.0143835046824763 1.0692992471173444 1.0 10.919397188351892 -6.994984755285519 23.284211329653598 1.0646979659057796 1.0041959799387197 0.038704982264303966 0.1043099076372205 200.31616307564522 929984.3782798789 0.041314569488263966 0.03628170480476003 1.0116149636003595e-07 6.994984755285519 -0.06050198596705991 SPS(ph)PLGTSVR ddPTM_A459_Selumetinib_30min_R2 4 SPSPLGTSVR 10 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 S(0.018)PS(0.978)PLGT(0.005)SVR;S(0.225)PS(0.774)PLGT(0.001)SVR;S(0.016)PS(0.97)PLGT(0.014)SVR;S(0.145)PS(0.818)PLGT(0.036)SVR 147.28 0.00083069 117394000.0 435006.0 418736.0 441184.0 492831.0 449756.0 374557.0 396694.0 425417.0 398429.0 404962.0 True False 410830.1079869901 450851.7047515478 412798.7017648189 425706.56761910504 393253.6304103449 426148.82686008554 415141.05703424895 426654.89303842466 478125.93303640495 393269.69484236283 1.0446523425906644 1.1464186299233303 1.049658051913418 1.0824799703667585 0.9999591516147097 1.083604540214831 1.055614156083532 1.0848913573405239 1.2157711090046124 1.0 18.585159491673252 -8.013395969828192 24.583416920448514 1.1220341069382898 1.0674923639285039 0.06233761819963657 0.059945050417399545 1033.89356178455 1897324.0370581804 0.03496515180202098 0.01448244234951906 9.696255039515822e-09 8.013395969828192 -0.05454174300978587 SPS(ph)PLTGK ddPTM_A459_Selumetinib_30min_R1 2 SPSPLTGK 8 0 Q9P2F8;Q9P2F8-2 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 S(0.179)PS(0.808)PLT(0.013)GK;S(0.114)PS(0.865)PLT(0.021)GK 101.97 0.016599000000000003 22144600.0 10179.1 11509.900000000001 11900.6 12365.900000000001 11620.8 10038.4 11773.5 11461.3 5822.700000000001 9589.0 True False 10416.25322491929 10162.315557192655 10284.5638853166 10206.427701691864 10569.700691818873 9937.422810137943 10885.415416100768 11157.309092450769 9880.696626818091 10819.841554769639 0.9626992384493434 0.9392296093941291 0.950528141586595 0.943306577090552 0.9768812822549607 0.9184443930934733 1.0060605195555958 1.0311896931182294 0.913201600670617 1.0 13.401391752113271 -7.274725603870902 24.993518697571027 0.99021209493635 0.949236968955288 0.2670360247961071 0.03160279100426055 1045.5551551412982 1966848.6931866636 0.012633134053850685 0.008575149200167487 5.3121997385831574e-08 7.274725603870902 -0.04097512598106201 SPS(ph)PLVSLQAVK ddPTM_A459_Selumetinib_30min_R2 1 SPSPLVSLQAVK 12 0 Q9UPZ3;Q9UPZ3-2 Q9UPZ3 HPS5 Hermansky-Pudlak syndrome 5 protein 1 S(0.011)PS(0.979)PLVS(0.01)LQAVK 78.28699999999998 0.044235 45019000.0 69744.0 49667.0 73722.0 59404.0 75134.0 59654.0 61181.0 52640.0 41571.0 58230.0 True False 65867.90768735288 53476.29919542408 68978.80678244459 51313.07272238422 65694.99521351772 67870.79701490432 64026.03772785158 52793.17368497885 49886.36159078877 56548.74860029047 1.1647986793294758 0.9456672432031394 1.2198113749610062 0.9074130549746708 1.161740919819051 1.2002174883593393 1.132227313824637 0.9335869491673892 0.8821832989339136 1.0 15.787207477891315 -7.768461872825364 24.830728715889677 0.9309137596734148 1.101172245499089 0.3621017144597758 0.1007202346351224 163.08755631339608 576646.3634816823 0.05230205591236793 0.025982493165498898 1.704268932330932e-08 7.768461872825364 0.17025848582567427 SPS(ph)PPDGS(ph)PAATPEIR ddPTM_A459_Selumetinib_30min_R1 1 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 2 S(0.132)PS(0.868)PPDGS(0.998)PAAT(0.002)PEIR 122.46 0.045731 0.0 415.3 482.95 497.74 743.38 569.24 440.76 558.6 439.71 271.35 494.94 True False 424.9756819668715 426.4059894826363 430.14964189011357 613.5626379708473 517.7523425074847 436.32635457806003 516.4643522685597 428.04746242062646 460.46113138013067 558.470370123859 0.760963704972601 0.763524821179084 0.7702282249901886 1.098648506338429 0.9270900842826385 0.7812882794145202 0.9247838021451646 0.7664640513080273 0.8245041384702441 1.0 9.125336929732505 -9.4637623776833 0.017416209074025357 1.8127942695116908 5.1649364459969165e-06 0.13486039486549561 0.10547824949901845 2802.0184005729766 15.294628222724857 843.9415182264713 747.0709072374383 3.43745975555416e-10 9.4637623776833 -1.8127891045752447 SPS(ph)PPDGSPAATPEIR ddPTM_A459_Selumetinib_30min_R1 2 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 S(0.007)PS(0.993)PPDGSPAATPEIR;S(0.489)PS(0.511)PPDGSPAATPEIR 254.72 5.7234e-30 105270000.0 2375.1000000000004 2657.1 2301.3 2771.0 2244.33 2080.15 2800.2 2348.2 1364.7 2022.42 True False 2430.435208859901 2346.005496747722 1988.7961001360518 2287.0968681121585 2041.3307477686449 2059.225579625083 2588.9786595460446 2285.918107971424 2315.796226255626 2282.017307039024 1.065038026382654 1.0280401859842703 0.8715078952300171 1.0022259082161498 0.8945290386151031 0.9023707108939418 1.134513157091394 1.001709365183326 1.0148022186827457 1.0 11.1560940178683 -7.2418918055298205 24.990836328641453 1.0378986520201425 0.9585199278533169 0.23845716130845784 0.06746987197187654 1237.7696535674118 1582444.4231768362 0.02660670275858378 0.02057221198426861 5.7293874770440486e-08 7.2418918055298205 -0.07937872416682568 SPS(ph)PPDGSPAATPEIR ddPTM_A459_Selumetinib_30min_R2 4 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 S(0.066)PS(0.934)PPDGSPAATPEIR;S(0.009)PS(0.651)PPDGS(0.328)PAAT(0.011)PEIR;S(0.004)PS(0.989)PPDGS(0.007)PAATPEIR;S(0.022)PS(0.977)PPDGSPAATPEIR 174.21 3.2761000000000007e-06 91151000.0 100178.0 89802.0 104389.0 112564.0 117006.0 84506.0 92933.0 86985.0 82344.0 100589.0 True False 94610.50780430778 96689.52464105895 97672.72539014953 97232.58901626902 102306.66023308832 96145.93443091011 97254.56864324599 87238.11194885796 98815.10088359461 97684.73420839118 0.9685291010003145 0.9898120256414974 0.9998770655585136 0.9953713832996914 1.047314721815562 0.9842472850036288 0.9955963890506421 0.8930577807864286 1.0115715795754945 1.0 16.575845500569486 SPS(ph)PPLPLSCSNSTR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPLPLSCSNSTR 15 0 Q96HJ3-2;Q96HJ3 Q96HJ3-2 CCDC34 Coiled-coil domain-containing protein 34 1 S(0.004)PS(0.996)PPLPLSCSNSTR 134.37 0.00045661 31641000.0 21231.0 19982.0 22715.0 21681.0 21702.0 19082.0 15769.0 18593.0 14163.0 18521.0 True False 20051.06601442691 21514.555147743227 21253.54163022202 18728.010398188864 18975.600741658393 21710.37229085067 16502.28974568071 18647.10255176315 16995.995747283956 17986.25060666289 1.1147996574115966 1.1961667619472232 1.1816549260327098 1.0412403789843334 1.055005912940466 1.2070538082466284 0.9174947078502035 1.036742062565027 0.9449437861711935 1.0 14.134606854913958 -7.030059997019449 0.7174944597396299 0.966699095907394 1.1543925106189872 0.46994670067578337 0.07100915850223422 0.6304264559072532 0.6760249877106548 0.056881428035738514 0.044239186860925 9.331253822605701e-08 7.030059997019449 0.18769341471159318 SPS(ph)PPLPTHIPPEPPR ddPTM_A459_Selumetinib_30min_R1 1 SPSPPLPTHIPPEPPR 16 0 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 S(0.246)PS(0.754)PPLPTHIPPEPPR 123.59 0.00089596 5290500.0 1543.2 1753.6 1873.0 1757.4 1759.7 1497.9 1621.2 1565.2 837.31 1295.8 True False 1579.1535574555169 1548.2876967734767 1618.6568876525532 1450.5030804836917 1600.5354457002686 1482.8324859843835 1498.9115787643914 1523.685811513873 1420.8539152972082 1462.1285521608604 1.0800374256570715 1.05892720204751 1.1070551117139198 0.9920489401154313 1.0946612343592212 1.0141601323583518 1.0251571768769372 1.0421011266499365 0.9717708563979187 1.0 10.513854445071264 -6.911530501653875 0.4335745234364955 0.9915225573855188 1.0835760690779033 0.4170244168138183 0.033169652755535226 1.2321726023082225 0.49750180935862703 0.031821593583871766 0.04368714517800378 1.2259407985789518e-07 6.911530501653875 0.09205351169238452 SPS(ph)PPLPTHIPPEPPR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPLPTHIPPEPPR 16 0 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 S(0.272)PS(0.725)PPLPT(0.003)HIPPEPPR 80.382 0.015359 1820500.0 11535.0 10537.0 10900.0 11135.0 11374.0 9822.3 10685.0 9666.9 6297.7 12409.0 True False 10893.930878263594 11345.154018204916 10198.70586702267 9618.393791053604 9945.096435149875 11175.232667038172 11181.873671925827 9695.029078558548 7557.415972440172 12050.719927546023 0.9040066438986609 0.9414503105554469 0.8463150690034756 0.7981592675693583 0.8252699004660271 0.9273497960477344 0.9279008838605441 0.8045186625238263 0.6271339818598825 1.0 13.556831717280621 -7.919118257609814 7.326643698785702 0.7816821027783718 0.878454380413273 0.08516254003209411 0.09557025943157137 0.3966911565924098 29.988189310120074 0.05128406527169919 0.024429469036911775 1.2047078559132959e-08 7.919118257609814 0.09677227763490115 SPS(ph)PPLPTHIPPEPPRT(ph)PPFPAK ddPTM_A459_Selumetinib_30min_R1 2 SPSPPLPTHIPPEPPRTPPFPAK 23 1 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 2 S(0.385)PS(0.597)PPLPT(0.018)HIPPEPPRT(1)PPFPAK;S(0.377)PS(0.514)PPLPT(0.131)HIPPEPPRT(0.977)PPFPAK 112.9 1.8932e-05 33090000.0 10660.2 11831.0 12089.3 13441.400000000001 12091.5 11265.1 11116.7 11094.599999999999 6424.9 9703.9 True False 10908.561918861653 10445.821019917315 10447.639461771496 11094.111816327239 10997.825959927706 11151.783321892426 10278.158368893484 10800.33516766024 10902.586043870286 10949.49008899041 0.9962620935042529 0.9540006826820614 0.9541667581649744 1.013208078747178 1.0044144403569897 1.0184751281802082 0.938688311999849 0.9863779116545214 0.9957163260810397 1.0 13.418576065520751 -5.7499513096218555 24.99723902790114 0.9924415176326614 0.9667289301240625 0.20086925735979289 0.02332038898581367 381.3867202966851 829863.0465128855 0.006653638808161764 0.011397404781368093 1.77847879076882e-06 5.7499513096218555 -0.02571258750859895 SPS(ph)PPTQHTGQPPGQPSAPSQLSAPR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPTQHTGQPPGQPSAPSQLSAPR 26 0 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7;Q68EM7-2;I3L460 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 S(0.088)PS(0.393)PPT(0.393)QHT(0.127)GQPPGQPSAPSQLSAPR 84.947 6.2296e-05 173030000.0 4666.5 3700.8 4413.7 4210.3 5229.5 3405.5 2316.0 3965.9 4071.7 4415.1 True False 4407.154611479591 3984.639460052454 4129.727347273211 3636.8498768273885 4572.523457676829 3874.5767129489545 2423.698589066936 3977.4401124099104 4886.153772803511 4287.624591192558 1.027877911823849 0.9293349674870132 0.9631737246204596 0.8482202206550543 1.0664467843265704 0.90366510186268 0.565277705059717 0.9276558681420444 1.1395945864384731 1.0 12.065962878859267 -1.5228926814809096 0.8079324080557111 0.9081893998363041 31.235988427421994 0.03212977100044789 0.14526701955046203 1975.4388349458238 6.636256847991503 0.05425165109895725 109734.91004357678 0.029999037336814964 1.5228926814809096 30.32779902758569 SPS(ph)PSLSSLLLPSSPGPR ddPTM_A459_Selumetinib_30min_R1 2 SPSPSLSSLLLPSSPGPR 18 0 Q8TER5;Q8TER5-2;Q8TER5-4;Q8TER5-3 Q8TER5 ARHGEF40 Rho guanine nucleotide exchange factor 40 1 S(0.133)PS(0.655)PS(0.207)LS(0.003)S(0.001)LLLPSSPGPR;S(0.11)PS(0.871)PS(0.019)LSSLLLPSSPGPR 176.17 2.3189e-09 32150000.0 2656.2400000000002 3449.1 2888.28 3322.1000000000004 3064.73 2898.62 3197.3 3207.89 2131.29 2934.41 True False 2718.1252238566885 3045.2777685569104 2496.0674401863967 2741.9575985403862 2787.5257126220285 2869.462514536386 2956.125086839002 3122.8063365047497 3616.643466737271 3311.070107073893 0.820920468597021 0.9197261519926341 0.7538552067664486 0.8281182547848704 0.8418806073198678 0.86662692777358 0.8928005119926113 0.9431411101302478 1.0922883991524492 1.0 11.693081842680916 -7.833847159670149 1.6322667107904203 1.0449282260481827 0.8377692053608863 0.7533286958197373 0.046160610963351806 0.18639987675124706 0.925775665730194 0.036676905160289666 0.01362671522817238 1.4660636988458749e-08 7.833847159670149 -0.2071590206872964 SPS(ph)PSPTPEAK ddPTM_A459_Selumetinib_30min_R1 1 SPSPSPTPEAK 11 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 SPS(0.998)PS(0.002)PTPEAK 152.96 0.00056908 8776700.0 3719.4 4411.5 4200.6 4100.1 4378.6 3894.9 4239.8 3540.2 1942.8 3353.2 True False 3806.054783307446 3894.9995291492914 3630.1815922441665 3384.094503409119 3982.556403104618 3855.7208422862473 3919.9884725174393 3446.302395809742 3296.7897035021847 3783.6158829339406 1.0059305439737465 1.029438412793896 0.9594477094300609 0.8944075213007565 1.0525794706243838 1.0190571563243345 1.0360429266085411 0.9108489081448102 0.8713330859964953 1.0 11.885549916702226 -7.775596129242316 24.924376137878912 0.9183182071397392 0.9979092881438005 0.28267634073923775 0.05203449239944818 292.1336855404028 514322.76086336165 0.029182319447701065 0.0141236319299032 1.67650120824168e-08 7.775596129242316 0.07959108100406131 SPS(ph)PSVR ddPTM_A459_Selumetinib_30min_R1 1 SPSPSVR 7 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 S(0.221)PS(0.769)PS(0.01)VR 87.696 0.033251 26896000.0 593.42 541.77 638.55 718.12 575.93 450.21 597.74 679.56 370.63 452.03 True False 607.2455314056847 478.3393165379601 551.838417304078 592.7138227819216 523.8372331886999 445.68129615797375 552.651990556765 661.5358612780267 628.9320402558237 510.05245364506385 1.1905550636332312 0.9378237730639909 1.0819248360838045 1.162064447580092 1.0270261998449841 0.8737950243606027 1.083519913701553 1.296995743379714 1.2330732569977714 1.0 8.99450181082415 -7.563057715085792 10.794950514446398 1.1973182199278634 1.0410869524804265 0.2056177393299714 0.11297826148748226 0.7305525977935553 191.7661537059205 0.05269015732475775 0.03042660572131908 2.7349052499409887e-08 7.563057715085792 -0.15623126744743687 SPS(ph)PVLR ddPTM_A459_Selumetinib_30min_R1 1 SPSPVLR 7 0 A0A0A0MSA7;A0A0U1RQK7;O43432;O43432-3;O43432-2 A0A0A0MSA7 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 1 S(0.308)PS(0.692)PVLR 96.668 0.022997 9561800.0 1382.9 1641.9 1490.4 1779.5 1796.9 1343.3 1656.0 1435.8 855.35 1333.6 True False 1415.1188793450196 1449.6655847013985 1288.0118661811885 1468.7437303520705 1634.3707122684611 1329.7876216188145 1531.08658674675 1397.7179198643094 1451.466477707739 1504.7805503640407 0.9404154506134932 0.9633734196994316 0.8559466467516403 0.9760517771157715 1.0861189771977513 0.8837086718705319 1.0174816430052511 0.928851665132281 0.964570200855265 1.0 10.555337391589923 -5.948784097391686 24.99854139356397 0.978836896383676 0.9228813893092854 0.1905237848027892 0.0562400985999069 181.85252774573422 88761.02629029912 0.015567634787379762 0.023090530576170425 1.125164192471162e-06 5.948784097391686 -0.055955507074390565 SPS(ph)PVQGK ddPTM_A459_Selumetinib_30min_R1 1 SPSPVQGK 8 0 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 S(0.123)PS(0.877)PVQGK 83.081 0.039762 74777000.0 5167.6 7477.8 6505.2 5429.1 5714.7 6554.4 5814.5 6843.9 5984.3 5043.2 True False 5287.995025600785 6602.295699665097 5621.829570505818 4481.009601828844 5197.806394012232 6488.468686919045 5375.907583719194 6662.377539879756 10154.920024021061 5690.543844927963 0.929260044330214 1.1602222704161727 0.9879248317393442 0.7874483922697145 0.9134111845294167 1.1402194348616221 0.944708929448069 1.170780459905954 1.7845253987581944 1.0 12.474350822059883 -8.012420901204834 10.809946874491137 1.4208777333985412 0.9889790934083091 0.39545249145116435 0.20332983574803987 0.3541261324760711 296.1807171001395 0.11762806806878959 0.04970897054969818 9.718049319505091e-09 8.012420901204834 -0.43189863999023204 SPS(ph)S(ph)STGSIASSRKY(ph)PY(ph)PMPPLPDEDK ddPTM_A459_Selumetinib_30min_R2 1 SPSSSTGSIASSRKYPYPMPPLPDEDK 27 2 H7C3I4;H7C0Q9;Q9P0K1-5;Q9P0K1-2;Q9P0K1 H7C3I4 ADAM22 Disintegrin and metalloproteinase domain-containing protein 22 4 S(0.061)PS(0.367)S(0.367)S(0.367)T(0.367)GS(0.367)IAS(0.117)S(0.117)RKY(0.935)PY(0.935)PMPPLPDEDK 42.041 0.024486 9044400.0 14620.0 14046.0 16013.0 15904.0 15197.0 14227.0 13924.0 13269.0 10550.0 13307.0 True False 13807.478928497087 15123.28303499156 14982.741013636163 13737.847764069737 13287.816997096235 16186.640110152623 14571.493589882579 13307.610593198804 12660.29479162929 12922.792334261814 1.0684593988165956 1.1702798159880392 1.1594043010281043 1.0630711543392204 1.0282465780918448 1.2525652112537216 1.1275808829063678 1.029778259139608 0.9796872428309034 1.0 13.657630218275289 -7.861326098541242 3.8278262048173826 0.9941710419964774 1.1263573531435227 0.46593736674239505 0.0602434683488705 0.2124936156824098 5.798398787527609 0.03777002534430298 0.01692897075435916 1.3761757522577436e-08 7.861326098541242 0.13218631114704527 SPS(ph)SLLIANLHLQ ddPTM_A459_Selumetinib_30min_R1 2 SPSSLLIANLHLQ 13 0 Q658Y4 Q658Y4 FAM91A1 Protein FAM91A1 1 S(0.069)PS(0.776)S(0.154)LLIANLHLQ;S(0.039)PS(0.48)S(0.48)LLIANLHLQ 118.73 0.0033659 10617500.0 2280.8 2647.6 3019.1000000000004 2778.8 2643.6 2362.56 2021.4299999999998 2229.8 1351.54 1648.1100000000001 True False 2333.938202335758 2337.6177611641533 2609.12280272922 2293.534744536295 2404.4868467654883 2338.794791432848 1868.9519076373692 2170.658460588827 2293.464667423997 1859.6609724508687 1.2550342438276982 1.2570128619107277 1.4030099256697455 1.23330799458227 1.292970537310673 1.2576457892486301 1.0049960370864028 1.167233432730532 1.2332703118469026 1.0 10.860823917852747 -7.097354905202607 6.831978846282098 1.115804701482707 1.2884909050314515 0.5670935357901565 0.07776244963638618 0.2036908312346385 12.27806607299311 0.029639947569722318 0.022962994893538036 7.991808979084665e-08 7.097354905202607 0.17268620354874442 SPS(ph)WQRPNQGVPSTGR ddPTM_A459_Selumetinib_30min_R2 1 SPSWQRPNQGVPSTGR 16 1 Q96HC4;H0Y8Y3;Q96HC4-7;Q96HC4-4;Q96HC4-6;A0A0A0MSP3 Q96HC4 PDLIM5 PDZ and LIM domain protein 5 1 S(0.181)PS(0.819)WQRPNQGVPSTGR 110.22 0.013454 40981000.0 17160.0 19729.0 16902.0 18680.0 19878.0 14421.0 15554.0 18559.0 20571.0 16618.0 True False 16206.315896922708 21242.150861266466 15814.543721506167 16135.751775202632 17380.74792842528 16407.361849195964 16277.291819666292 18613.003617392154 24685.77480176363 16138.195161250695 1.004221087611803 1.3162655829240957 0.9799450039790295 0.9998485960775881 1.0769945309719684 1.0166788593926268 1.0086190963131727 1.1533510055748801 1.529649044091155 1.0 13.978191621268644 -8.007414390101209 24.285774449942366 1.2903830301542154 1.0628364349800936 0.23071239881296324 0.15011381418357364 276.50002487701215 905666.7849826165 0.08262322281238106 0.036989902414223993 9.830726411880083e-09 8.007414390101209 -0.2275465951741218 SPSDLHIS(ph)PLAK ddPTM_A459_Selumetinib_30min_R1 2 SPSDLHISPLAK 12 0 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785;O95785-2 B9EGQ5 WIZ Protein Wiz 1 SPSDLHIS(1)PLAK;SPSDLHIS(1)PLAK 88.561 0.017846 33023000.0 13663.099999999999 16090.0 16195.3 17161.6 16504.9 13945.9 14641.7 14033.3 6697.9 12438.0 True False 13981.423646235395 14206.175319961927 13996.067214415067 14164.648723130142 15012.034709176763 13805.616907864067 13537.264780899708 13661.091297417335 11365.847104739187 14034.53845637968 0.9962154216678112 1.0122296051356237 0.997258816733861 1.0092707193154127 1.0696493337372803 0.9836887013258672 0.9645678639860134 0.9733908485752457 0.8098482996120627 1.0 13.77669399932144 -7.65790067933794 1.7182441327643132 0.9103722481718679 1.0131381703288114 0.37559485677941573 0.05004760706712932 0.36269585514771074 2.0784212087759384 0.0337295120776744 0.014671363666939538 2.1983625682365232e-08 7.65790067933794 0.10276592215694347 SPSDLHIS(ph)PLAK ddPTM_A459_Selumetinib_30min_R2 2 SPSDLHISPLAK 12 0 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785;O95785-2 B9EGQ5 WIZ Protein Wiz 1 SPSDLHIS(1)PLAK;SPSDLHIS(1)PLAK 89.46600000000002 0.017026 13809300.0 182799.0 179078.0 211501.0 243433.0 257420.0 214379.0 185942.0 189241.0 172904.0 243134.0 True False 172639.76338237588 192812.70677347458 197893.25592487754 210277.0054546516 225080.59823600118 243907.7613111977 194588.6714370831 189791.6599794657 207489.63134140984 236114.0896820033 0.7311709505133125 0.8166082211915151 0.8381255696828541 0.8905737295806917 0.9532705080799627 1.0330080752050455 0.8241298589980534 0.8038133608844593 0.8787685293192598 1.0 17.84912460879392 -5.113842323343692 1.2867685215050895 0.9063978011515206 0.716118849439639 0.416505876960404 0.06834295200138486 0.9419082521671104 2.040529467004862 0.023097326257979243 0.2023697693817512 7.694097344957219e-06 5.113842323343692 -0.19027895171188158 SPSDSSTAS(ph)TPVAEQIER ddPTM_A459_Selumetinib_30min_R1 1 SPSDSSTASTPVAEQIER 18 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 SPS(0.001)DS(0.024)S(0.125)T(0.125)AS(0.507)T(0.216)PVAEQIER 183.73 5.8839e-10 9080900.0 1607.6 1640.5 2186.6 1931.8 2009.5 1296.0 1695.2 1397.2 999.33 1488.8 True False 1645.0539521549308 1448.4294973522417 1889.6717301340504 1594.4473943771457 1827.7410798060405 1282.9634166738495 1567.329699186651 1360.1417172547804 1695.7900218246025 1679.9019821400602 0.9792559147166814 0.8622107198820367 1.1248702306587914 0.9491312060635513 1.0880045974335033 0.7637132584601496 0.9329887790179274 0.8096554035385262 1.0094577182796713 1.0 10.714161342662658 -6.747943499997272 24.999950420498703 0.8931305724485824 0.997034980655888 0.19525271241683606 0.09780824583638567 362.81897877327634 672089.8147515322 0.03090189032574653 0.03073668703792573 1.7867200049727804e-07 6.747943499997272 0.10390440820730562 SPSDSSTAS(ph)TPVAEQIER ddPTM_A459_Selumetinib_30min_R2 2 SPSDSSTASTPVAEQIER 18 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 SPSDS(0.002)S(0.01)T(0.01)AS(0.489)T(0.489)PVAEQIER;SPS(0.001)DS(0.012)S(0.022)T(0.201)AS(0.383)T(0.383)PVAEQIER 200.81 1.5137000000000002e-10 18553900.0 30617.0 33975.0 40245.0 43664.0 40040.0 29987.0 31899.0 33165.0 32347.0 42160.0 True False 28915.42970956192 36580.773253156665 37655.68051544289 37716.8878753987 35009.81723785836 34117.4370551168 33382.36670666937 33261.50465923868 38817.30385069506 40942.731255164836 0.7062408594422801 0.8934619682594351 0.9197158900016643 0.9212108405845738 0.8550923732876748 0.8332965586122925 0.8153429359322054 0.8123909577977364 0.9480877963117896 1.0 15.32131972609371 -8.448763457886228 4.266038477333632 0.9989862309654607 0.8506587536679737 0.437626994574036 0.05967963484760988 0.19841603976181615 6.5477053765173165 0.05962497180640733 0.015607765678686953 3.558250688934761e-09 8.448763457886228 -0.14832747729748696 SPSDSSTAST(ph)PVAEQIER ddPTM_A459_Selumetinib_30min_R1 1 SPSDSSTASTPVAEQIER 18 0 Q16643-3;Q16643;Q16643-2;D6R9Q9 Q16643-3 DBN1 Drebrin 1 SPSDSST(0.184)AS(0.184)T(0.631)PVAEQIER 231.41 1.4385e-18 6009600.0 1691.1 1460.6 2056.5 1944.9 1767.5 1651.4 1780.0 1518.6 1104.8 1411.0 True False 1730.499339692213 1289.5922729854826 1777.2385955459042 1605.2597252946002 1607.62993707747 1634.7884153512312 1645.7331669137786 1478.3217948920044 1874.7649086005836 1592.1155943038862 1.0869181521011555 0.8099865848932442 1.116274849580227 1.0082557642408252 1.0097444826425226 1.0268025897114603 1.033676934515132 0.928526672423157 1.1775306487216959 1.0 10.636729370088133 -5.288415335845368 24.99753631260454 1.0324800709752369 0.9484522016233343 0.13606812002079072 0.08910973947016045 1243.0087301227952 1151844.4773347848 0.021496661267282453 0.04476881148894679 5.147361432018693e-06 5.288415335845368 -0.08402786935190254 SPSEGQTATTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SPSEGQTATTSPR 13 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 SPSEGQTAT(0.002)T(0.046)S(0.952)PR 108.36 0.0063038 6103300.0 2374.4 2610.7 3096.5 2731.7 2767.9 2300.8 2396.8 2445.3 1440.7 2258.2 True False 2429.718900221862 2305.038030318497 2676.012307856984 2254.659875359792 2517.5439337124362 2277.6560409592544 2216.007446325249 2380.442700546174 2444.762675435249 2548.0619667307124 0.9535556560028678 0.9046240085267523 1.050214768242249 0.8848528429834971 0.9880230412695056 0.893877806229963 0.8696834987763247 0.9342169584676144 0.9594596628165989 1.0 11.315184647816753 -4.380936825768736 20.15855216317221 0.9392325362332726 11.365289992754455 0.0 0.054656717721664895 3046.540176942794 433107.2727016818 0.012851303174753035 1486.4008889474142 4.159711149335251e-05 4.380936825768736 10.426057456521182 SPSEGQTATTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 SPSEGQTATTSPR 13 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 SPSEGQTAT(0.001)T(0.106)S(0.893)PR;SPSEGQTAT(0.003)T(0.1)S(0.897)PR;SPSEGQTAT(0.007)T(0.073)S(0.92)PR 134.06 0.0012601 19871200.0 75861.0 76266.0 88945.0 86766.0 92245.0 60938.6 73515.0 76055.0 65468.0 74171.0 True False 71644.9493156441 82115.356966159 83222.37553599356 74948.32112030151 80656.35841923686 69332.3390044665 76933.59316720889 76276.30745841698 78563.42932875697 72029.49051059829 0.9946613367354361 1.1400241260081756 1.1553930889424848 1.0405227163070625 1.119768553789357 0.9625548995694349 1.0680846500766101 1.0589594195060121 1.0907119954874218 1.0 16.13630007919597 SPSFAS(ph)EWDEIEK ddPTM_A459_Selumetinib_30min_R1 1 SPSFASEWDEIEK 13 0 Q92625;A0A3B3ISP1 Q92625 ANKS1A Ankyrin repeat and SAM domain-containing protein 1A 1 S(0.003)PS(0.107)FAS(0.891)EWDEIEK 259.27 1.2244000000000001e-29 41855000.0 1481.5 1236.4 1872.4 1702.4 1446.7 1278.3 1167.3 1298.6 897.26 1230.9 True False 1516.016067502817 1091.6417132132344 1618.13836435699 1405.1077980058246 1315.8462404356308 1265.4414626035352 1079.2496212013787 1264.1569095527184 1522.5846867224473 1388.898004981328 1.0915244042871224 0.7859768746862806 1.1650519754175497 1.011670974374187 0.9474030747515694 0.9111118729129051 0.7770546269996894 0.9101870007867953 1.0962537790835953 1.0 10.439724942217198 -6.383202447523749 3.998508587975019 0.9238654940366122 1.0077832563608042 0.07724577957406475 0.1176636114720173 0.6086678593747602 16.757169641740877 0.03803599759645223 0.0433891486083476 4.138067327478132e-07 6.383202447523749 0.08391776232419201 SPSFGDPQLS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 1 SPSFGDPQLSPEAR 14 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 SPSFGDPQLS(1)PEAR 144.15 0.00053213 8834300.0 1537.3 2086.2 1314.4 1163.8 1674.9 1280.6 1568.3 1474.0 935.31 1579.9 True False 1573.1160989349187 1841.946734151933 1135.9116994823903 960.5641772316607 1523.4055907276122 1267.718326691769 1450.0018683544256 1434.904731773223 1587.1527576604021 1782.6955545292055 0.882436765457894 1.033236847128603 0.6371877108216466 0.538826820312197 0.8545517415226462 0.7111244112719867 0.8133760499208507 0.804907337165694 0.8903106049869269 1.0 10.799844627852947 -8.501459585908533 1.3704913905681297 0.9996920582840957 0.7754437456414731 0.2254914711866236 0.12825795107737065 0.7370332250547569 3.0443448950607657 0.1317405956066879 0.03981046466181612 3.151667650931626e-09 8.501459585908533 -0.22424831264262257 SPSFGDPQLS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 2 SPSFGDPQLSPEAR 14 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 SPSFGDPQLS(1)PEAR;SPSFGDPQLS(1)PEAR 161.48 0.00028289 32175000.0 81287.0 64383.0 83219.0 80360.0 90620.0 67442.0 76017.0 87740.0 67046.0 66728.0 True False 76769.39395764307 69320.96907602603 77864.78014199619 69414.82937126794 79235.50544692116 76731.52332247925 79551.94112482788 87995.30887386111 80457.07342176106 64801.389259834854 1.1846874709710309 1.0697451068227715 1.2015912163515647 1.0711935371159178 1.2227439311402672 1.1841030601181712 1.227627093083569 1.3579231846562014 1.241594884627418 1.0 15.983737122548076 -6.295091429825625 21.38001323721498 1.2235816147636775 1.1323563486787778 0.11595463606096312 0.09226568779510808 185.8394089800906 118067.246204379 0.027671822890084383 0.03138227276556537 5.068839853137173e-07 6.295091429825625 -0.09122526608489978 SPSFGDPQLS(ph)PEARPR ddPTM_A459_Selumetinib_30min_R1 2 SPSFGDPQLSPEARPR 16 1 O95425-3 O95425-3 SVIL Supervillin 1 SPSFGDPQLS(1)PEARPR;SPSFGDPQLS(1)PEARPR 136.36 0.0019465 31191000.0 3691.4 4245.799999999999 4482.6 4444.4 4577.7 3963.3 3829.1 3508.8 2524.02 3020.6 True False 3777.4024377859587 3748.6997621811292 3873.8875411592835 3668.2689717205635 4163.647843258576 3923.4328003884802 3540.2679041739048 3415.7352258113183 4283.077592872958 3408.323433135588 1.10828755307146 1.0998662056941004 1.1365962230865474 1.0762678612181564 1.2216117175910461 1.1511327716862252 1.038712426689192 1.0021746154146267 1.2566523327079362 1.0 11.734846531387904 -10.515572592268976 4.927644599667516 0.9999987207267146 1.1176549100851583 0.19750731413845013 0.07300104740365386 1.0220326244237247e-06 2.0888157791994878e-07 0.07041183781443633 0.017077193587314375 3.0508960296247596e-11 10.515572592268976 0.11765618935844369 SPSFGDPQLS(ph)PEARPR ddPTM_A459_Selumetinib_30min_R2 3 SPSFGDPQLSPEARPR 16 1 O95425-3 O95425-3 SVIL Supervillin 1 SPSFGDPQLS(1)PEARPR;SPSFGDPQLS(1)PEARPR;SPSFGDPQLS(1)PEARPR 159.4 3.3983e-05 53340100.0 131081.0 120463.0 131113.0 148178.0 138528.0 96474.0 100480.0 96722.0 83506.0 110736.0 True False 123796.04277881848 129702.1247504048 122677.33232504086 127995.90077869274 121124.8741839672 109762.41779622287 105152.5190973428 97003.44500681086 100209.53335258737 107538.76395331879 1.151175987410054 1.206096480769547 1.1407731297552717 1.1902303511155674 1.1263368643194185 1.0206776957550798 0.9778103748987497 0.9020323596886312 0.9318456867896218 1.0 16.71449726897327 -6.871111548788356 1.6567702517449148 0.9405642578158738 1.1742125087542896 0.918925031304385 0.029944774225272586 0.08891109341974814 0.5024183324760951 0.013072741529609496 0.010918639021277682 1.345514713438061e-07 6.871111548788356 0.2336482509384158 SPSGPVKS(ph)PPLSPVGTTPVK ddPTM_A459_Selumetinib_30min_R1 2 SPSGPVKSPPLSPVGTTPVK 20 1 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 S(0.01)PS(0.05)GPVKS(0.937)PPLS(0.002)PVGTTPVK;S(0.058)PS(0.236)GPVKS(0.704)PPLS(0.001)PVGTTPVK 56.327 0.023035 36077000.0 3957.2 4301.1 4953.9 5626.8 4141.0 4278.0 4452.7 3115.7 2340.0 3366.0 True False 4049.3950606291905 3797.5252124728563 4281.187589824874 4644.185008117465 3766.447281152932 4234.96720411322 4116.829254110661 3033.061514780074 3970.809093161989 3798.0588876164993 1.0661749015614708 0.999859487396211 1.1272041104427335 1.2227785680890164 0.9916769045981261 1.1150346346448845 1.0839298114975275 0.798582013741102 1.045483814405495 1.0 11.891046558820818 -7.587348064363522 24.181677958603974 0.9414691418938271 1.087861267888351 0.3565751454605278 0.08521538444258653 47.07139129105091 17654.784385026527 0.039162353339751696 0.022610394911740914 2.58613942857451e-08 7.587348064363522 0.1463921259945239 SPSGPVKS(ph)PPLSPVGTTPVK ddPTM_A459_Selumetinib_30min_R2 2 SPSGPVKSPPLSPVGTTPVK 20 1 C9J4K0;Q9BVC5-2;Q9BVC5 C9J4K0 C2orf49 Ashwin 1 S(0.007)PS(0.03)GPVKS(0.963)PPLSPVGTTPVK;S(0.074)PS(0.285)GPVKS(0.64)PPLS(0.001)PVGTTPVK 82.302 0.001848 38802000.0 142319.0 121040.0 114789.0 145041.0 131294.0 120692.0 118831.0 133879.0 103902.0 124618.0 True False 134409.4797280967 130323.37879505761 107403.60071281348 125286.16559031904 114799.67393674771 137316.2274671075 124356.87695915958 134268.56572513832 124685.30326444269 121019.95454355172 1.1106389870583404 1.0768751259789793 0.8874867051297883 1.035252128980366 0.9486011986183196 1.1346577346274842 1.0275733239877147 1.1094746005446465 1.0302871434278378 1.0 16.88488542232919 -6.756206141369516 24.99871025544612 1.065189142707283 1.0097875920906654 0.10804884561660644 0.06905888233792808 282.9845864774426 1351790.2188771232 0.023217466412854184 0.022551861676454035 1.753048205896086e-07 6.756206141369516 -0.05540155061661767 SPSGSAFGS(ph)QENLR ddPTM_A459_Selumetinib_30min_R1 2 SPSGSAFGSQENLR 14 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SPSGSAFGS(1)QENLR;SPSGSAFGS(1)QENLR 174.39 8.663799999999999e-05 28355000.0 2970.7 3421.6000000000004 3524.7 3947.8 3588.8 2821.3999999999996 3178.9 3143.2 1833.9 2455.5 True False 3039.9115300240437 3020.997481341317 3046.0650997912194 3258.3908393840416 3264.1936736541015 2793.019277626235 2939.113013652926 3059.832125447486 3111.9943572434936 2770.6873435954562 1.0971687357835265 1.0903422532767768 1.099389690010426 1.1760225659946546 1.178116932319846 1.0080600700336688 1.0607884070524203 1.10435850242013 1.1231849614634364 1.0 11.436028204686178 -6.757522451263863 24.999998696643747 1.0658951737034825 1.1271597166257705 0.36260786465768835 0.04526045633624269 139.6761840303673 891488.9352188982 0.01636708958179443 0.01577652404421859 1.747742908860634e-07 6.757522451263863 0.061264542922288 SPSGSAFGS(ph)QENLR ddPTM_A459_Selumetinib_30min_R2 2 SPSGSAFGSQENLR 14 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GWE0 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 SPSGS(0.003)AFGS(0.997)QENLR;SPSGSAFGS(1)QENLR 127.29 0.0012285 41635000.0 27132.0 20010.0 31113.0 36338.0 37973.0 27786.0 22851.2 35044.0 20376.0 32050.0 True False 25624.11205800157 21544.702657709033 29111.223453273087 31388.70171345357 33202.492257072794 31613.269283805497 23913.826078793772 35145.972238153496 24451.769353008392 31124.633224099423 0.8232743458695967 0.6922074391234025 0.9353113735885769 1.0084842281498656 1.0667593098370878 1.0156993355130601 0.7683247512223723 1.1292011695399 0.7856082729378377 1.0 14.925769215962598 -5.368592493245724 5.29360863351201 0.9707366571325875 0.7593172339521381 0.3573819231661247 0.11083904071898351 0.21324007570530804 8.611402189080575 0.0279374128281108 0.05995049738812365 4.279642648029721e-06 5.368592493245724 -0.21141942318044937 SPSLS(ph)PSPPSPLEK ddPTM_A459_Selumetinib_30min_R1 2 SPSLSPSPPSPLEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SPS(0.001)LS(0.515)PS(0.28)PPS(0.205)PLEK;S(0.029)PS(0.118)LS(0.846)PS(0.007)PPSPLEK 142.95 0.00054195 22969900.0 6296.5 12145.7 7455.0 9337.599999999999 7494.799999999999 7297.1 6028.4 6027.799999999999 3904.4 6094.5 True False 6443.196199143766 10723.675797617263 6442.651947383764 7706.963448460515 6816.896663314409 7223.69779923669 5573.672934507315 5867.923162946152 6625.4816339066965 6876.788440457148 0.9369484396578938 1.5594017309778379 0.9368692963536154 1.1207213243785903 0.9912907343796725 1.0504464201252177 0.8105052209715492 0.8532941232311737 0.9634557891774048 1.0 12.747519247443114 -6.0968753588457965 0.9110780337500511 0.9084417879688242 1.2198528759245952 0.25121021223723683 0.1713001125643081 0.753763425037126 1.2958341268132674 0.07631172883165016 0.15160397077967622 8.000638378728547e-07 6.0968753588457965 0.311411087955771 SPSLSPS(ph)PPSPLEK ddPTM_A459_Selumetinib_30min_R2 1 SPSLSPSPPSPLEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.125)PS(0.005)LS(0.052)PS(0.81)PPS(0.008)PLEK 128.71 0.0011125 6857400.0 36329.0 41824.0 42364.0 48514.0 44159.0 36889.0 34856.0 34712.0 26396.0 41712.0 True False 34309.9796165096 45031.76631464382 39638.34636243566 41906.30950868204 38611.35163353114 41970.12490499894 36476.873065853695 34813.00617311905 31675.937565862256 40507.66617920861 0.8469996633407604 1.1116850355046448 0.9785393754128657 1.0345278674729306 0.9531862799182741 1.0361032580677523 0.9004930796180057 0.8594177215518661 0.7819738966378809 1.0 15.30590734710469 -7.412295308977255 4.442510490051533 0.8676291163912913 0.997909977614353 0.2945700969974113 0.08122411439193523 0.24717449277260548 7.951146705924063 0.03358705910966374 0.021829867795517877 3.8699440927969535e-08 7.412295308977255 0.1302808612230617 SPSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R1 4 SPSLSPSPPSPLEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SPSLS(0.001)PS(0.019)PPS(0.98)PLEK;SPSLS(0.001)PS(0.011)PPS(0.989)PLEK;SPSLSPS(0.019)PPS(0.981)PLEK;SPSLSPS(0.026)PPS(0.974)PLEK 173.19 0.00010872 1972460000.0 18537.2 20264.699999999997 20055.0 21221.899999999998 17259.1 17761.1 17992.6 17052.3 11111.699999999999 15508.800000000001 True False 18969.080692887772 17892.099503196547 17331.64115422956 17515.89354940073 15698.017452341594 17582.439459788526 16635.403696074634 16600.01761032328 18855.743333541923 17499.505548504683 1.08397809528445 1.022434574142891 0.9904074778678837 1.0009364836538166 0.8970549144277379 1.0047392145483178 0.9506213561271801 0.9485992369505398 1.0775014917580417 1.0 14.095026538590027 -4.7354965276915815 1.3587994043240792 0.9772394063195438 1.1374168365895148 0.3236413801828004 0.0445159867373267 1.6073407824169856 2.455890705043215 0.012749539782434323 0.3676799386161559 1.8386686544862796e-05 4.7354965276915815 0.160177430269971 SPSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R2 6 SPSLSPSPPSPLEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SPSLS(0.04)PS(0.282)PPS(0.678)PLEK;S(0.001)PSLS(0.012)PS(0.059)PPS(0.927)PLEK;SPSLSPS(0.047)PPS(0.953)PLEK;SPSLS(0.002)PS(0.021)PPS(0.977)PLEK;SPSLSPS(0.039)PPS(0.961)PLEK;SPSLS(0.003)PS(0.016)PPS(0.981)PLEK 169.02 0.00018546 1405106600.0 363976.0 333032.0 364614.0 356417.0 366515.0 284680.0 309067.0 309799.0 285631.0 340176.0 True False 343747.6710313719 358574.48353334196 341155.13220170734 307872.3897463803 320470.1090143271 323892.08593225916 323439.22790464177 310700.4638000145 342765.1811969546 330354.23499660747 1.0405426497253834 1.0854242069487146 1.0326948955420863 0.9319462477892615 0.9700802201540359 0.9804387279478507 0.9790679023926038 0.940506979737085 1.0375686002647269 1.0 18.333654313989115 -5.569463219567209 6.383860783401256 0.9747344487955915 1.062229954491371 0.592427514876293 0.029469416203805797 0.11124713108066243 10.809732221944545 0.007636129300717483 0.01348368464462698 2.6948635508860472e-06 5.569463219567209 0.08749550569577946 SPSMAVPSPGWVAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SPSMAVPSPGWVASPK 16 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 SPSMAVPSPGWVAS(1)PK 203.11 3.9766e-07 11536000.0 1808.5 1971.0 1826.1 1943.5 1399.7 1728.0 1269.3 1343.0 968.9 1681.9 True False 1850.6345312715796 1740.2344037069593 1578.1256500492957 1604.1042090133465 1273.0973821371065 1710.6178888984662 1173.5556790807075 1307.379277321193 1644.1525343438682 1897.788248093342 0.9751533307948679 0.9169802824184031 0.831560450242432 0.8452493109412749 0.6708321560195949 0.901374476639888 0.6183807283345484 0.6888962868405802 0.866351942054497 1.0 10.890103312601608 -5.21915375777759 1.1830197288107422 0.7735734190034139 0.9995041456312749 0.21220884400426876 0.11021369321632353 1.0869718839310958 2.107761312421326 0.03436144553902332 0.25123961556369157 6.037348450285984e-06 5.21915375777759 0.22593072662786096 SPSMAVPSPGWVAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SPSMAVPSPGWVASPK 16 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 SPSMAVPSPGWVAS(1)PK;SPSMAVPSPGWVAS(1)PK 178.99 1.0862e-06 11203100.0 61642.0 53719.0 50030.0 59884.0 46877.0 37015.0 40338.0 46887.0 30786.0 48527.0 True False 58216.184412477225 57839.07456619049 46811.12426854537 51727.69589433802 40987.892174302826 42113.480261284836 42213.79692823063 47023.433407439305 36944.06023271087 47125.8994217121 1.2353331209983347 1.2273309427711963 0.9933205486361135 1.0976489898144153 0.8697529952164407 0.893637697700515 0.8957663927106219 0.9978256963680233 0.7839438755770421 1.0 15.524232532760694 -5.385321516875069 0.93160562821309 0.9057875888580824 1.3048878228426437 0.7132436596093485 0.07619585429563105 0.5066449581391573 0.6312872778071491 0.027503419535123617 0.1698682765612471 4.117925479789918e-06 5.385321516875069 0.3991002339845613 SPSPGGPQLS(ph)PQLPR ddPTM_A459_Selumetinib_30min_R1 2 SPSPGGPQLSPQLPR 15 0 Q9HCH0;H7C1V4;Q9HCH0-2 Q9HCH0 NCKAP5L Nck-associated protein 5-like 1 SPSPGGPQLS(1)PQLPR;SPSPGGPQLS(1)PQLPR 164.8 9.1467e-05 30852000.0 2988.1 3623.8999999999996 4225.0 4408.700000000001 4190.6 3449.1 3692.4 3186.0 1915.32 2856.2 True False 3057.716916169536 3199.6121032945957 3651.2682062637696 3638.8033065485665 3811.5609699105225 3414.4051855322327 3413.8792952317062 3101.4969304134897 3250.1581505619756 3222.8210917439824 0.9487702944487363 0.9927985489145389 1.132941637876628 1.1290739395587985 1.182678424090849 1.0594460841400841 1.0592829071328733 0.9623546706823741 1.0084823383116188 1.0 11.65410838704719 -10.32493936248213 6.760963028932592 0.9999999995491232 1.0572371396431095 0.041651582471880055 0.07343934869651682 5.721160493191996e-10 1.7474030348183814e-10 0.07928326391558496 0.019229015825419606 4.732173263930319e-11 10.32493936248213 0.05723714009398628 SPSPGGPQLS(ph)PQLPR ddPTM_A459_Selumetinib_30min_R2 4 SPSPGGPQLSPQLPR 15 0 Q9HCH0;H7C1V4;Q9HCH0-2 Q9HCH0 NCKAP5L Nck-associated protein 5-like 1 SPSPGGPQLS(1)PQLPR;SPS(0.004)PGGPQLS(0.995)PQLPR;S(0.005)PS(0.014)PGGPQLS(0.981)PQLPR;SPSPGGPQLS(1)PQLPR 135.69 0.00040872 41460400.0 72660.4 53859.5 67855.5 70736.0 80559.2 56341.5 64570.4 61271.3 50337.799999999996 61451.5 True False 68622.22585062715 57990.35046441177 63489.75100548228 61101.63477359383 70438.63308761435 64102.03020778549 67573.05154382037 61449.589338990256 60406.76655564713 59677.23552482828 1.1498894887997513 0.9717331902930609 1.0638855913335301 1.0238683852601207 1.1803266767997131 1.0741454365981198 1.1323086759893075 1.0296989932354457 1.0122246116865674 1.0 15.864893085601784 -7.959994401505725 10.919332246163064 1.0110381212454138 1.0809056597149476 0.24770702661785038 0.05737265098854163 0.8192159668535709 220.23852058878606 0.03165263620169897 0.015169724869643696 1.0964923309450917e-08 7.959994401505725 0.06986753846953375 SPSPPDGS(ph)PAATPEIR ddPTM_A459_Selumetinib_30min_R1 2 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 SPSPPDGS(0.999)PAAT(0.001)PEIR;S(0.447)PS(0.079)PPDGS(0.474)PAATPEIR 151.11 0.00021064 11032000.0 1650.69 2021.07 1961.54 2162.01 2390.6000000000004 2018.8600000000001 1687.06 1800.9499999999998 1214.33 1441.31 True False 1689.1478653163858 1784.4421848300483 1695.1736419679617 1784.455539454049 2174.370652094711 1998.552101378217 1559.8037059402027 1753.182955689949 2060.6293188458976 1626.3161780482883 1.0386343615812152 1.0972295602270428 1.0423395308053247 1.0972377718061814 1.3369913436538108 1.228882875516028 0.9591023732003293 1.0780086795876993 1.2670533237385737 1.0 10.667392048937687 -6.008552121474979 24.35238078925711 1.150469939610175 1.0642847371894055 0.108367602279972 0.11012210757159406 705.9435328711693 2010207.1234714475 0.03333184241737306 0.04679221082474743 9.805006333286615e-07 6.008552121474979 -0.08618520242076944 SPSPPDGS(ph)PAATPEIR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPDGSPAATPEIR 16 0 O00499-6;O00499-11;O00499-2;O00499;O00499-9;O00499-10;O00499-7;O00499-8;O00499-4;O00499-3;O00499-5 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 SPSPPDGS(0.993)PAAT(0.007)PEIR 84.859 0.01676 11234000.0 20750.0 17779.0 16423.0 19543.0 21150.0 14359.0 13481.0 14884.0 14776.0 15434.0 True False 19596.798068831362 19142.592131504705 15366.362060010397 16881.20968644459 18492.94791660101 16336.821911975925 14107.89321209473 14927.309975821163 17731.612875935032 14988.380317652136 1.3074660272499086 1.2771621566714626 1.0252183180802468 1.1262864518164932 1.2338189667379516 1.0899657978878279 0.9412553533539286 0.9959254875752619 1.1830239492289993 1.0 13.871556869977196 -1.5228787452952135 0.3869047056131218 1.040030410254991 5.285759171401462 0.4679731357728433 0.0888553782287141 65.70994218675588 0.8887950717559109 0.07097448259640472 210.39878699493102 0.029999999998972408 1.5228787452952135 4.24572876114647 SPSPPLPT(ph)HIPPEPPRT(ph)PPFPAK ddPTM_A459_Selumetinib_30min_R1 1 SPSPPLPTHIPPEPPRTPPFPAK 23 1 Q8IZ21-3;Q8IZ21;Q8IZ21-2 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 2 S(0.323)PS(0.374)PPLPT(0.652)HIPPEPPRT(0.651)PPFPAK 55.707 0.034821 11644000.0 1802.7 2431.5 2366.9 2535.1 2260.7 1913.7 1897.9 1969.8 1074.6 1798.5 True False 1844.699402556415 2146.8188496263188 2045.487980451057 2092.392374720727 2056.2200841590034 1894.4499155005765 1754.7398749919437 1917.554505187851 1823.517714321313 2029.3549938735207 0.9090077429160655 1.057882359718932 1.0079498099771802 1.031062766759641 1.0132382409024476 0.9335231742202753 0.8646786197039844 0.9449083629906115 0.8985700973099255 1.0 10.986805541626248 -6.80656917838827 5.243493230138139 0.9197397482148723 1.008729957911229 0.37122865951197714 0.0484824778782352 0.1791493481673305 11.13450977467058 0.016339811943546313 0.014681193569725201 1.5611003518536774e-07 6.80656917838827 0.08899020969635674 SPSPPT(ph)QHTGQPPGQPSAPSQLSAPR ddPTM_A459_Selumetinib_30min_R1 3 SPSPPTQHTGQPPGQPSAPSQLSAPR 26 0 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7;Q68EM7-2;I3L460 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 S(0.013)PS(0.052)PPT(0.875)QHT(0.061)GQPPGQPSAPSQLSAPR;S(0.143)PS(0.143)PPT(0.644)QHT(0.07)GQPPGQPSAPSQLSAPR;S(0.302)PS(0.302)PPT(0.372)QHT(0.024)GQPPGQPSAPSQLSAPR 119.43 1.0490000000000002e-08 316348400.0 1237.6100000000001 1388.21 1288.81 1301.09 1034.68 1070.37 1259.1000000000001 1027.19 468.78999999999996 785.0649999999999 True False 1266.4439050301467 1225.67772783868 1113.7966809265818 1073.8790559841386 941.0933766875904 1059.603049618201 1164.1250732927738 999.9455844166463 795.5023909330812 885.8357399306731 1.4296599786426099 1.383639960084026 1.2573399680326167 1.2122778609815203 1.0623791006233751 1.1961619991773276 1.3141545557688608 1.1288160313952829 0.8980247184374593 1.0 9.790895395149425 -1.522878745281107 0.18673564450402308 0.9757590270608816 3.0270729922993524 0.6503642628506158 0.0947494410865266 39.321550839523844 0.4543060505928471 0.21871943367862626 23.124639421632036 0.02999999999994685 1.522878745281107 2.051313965238471 SPSPPT(ph)QHTGQPPGQPSAPSQLSAPR ddPTM_A459_Selumetinib_30min_R2 3 SPSPPTQHTGQPPGQPSAPSQLSAPR 26 0 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7;Q68EM7-2;I3L460 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 S(0.009)PS(0.042)PPT(0.946)QHT(0.002)GQPPGQPSAPSQLSAPR;S(0.059)PS(0.059)PPT(0.808)QHT(0.073)GQPPGQPSAPSQLSAPR;S(0.013)PS(0.044)PPT(0.471)QHT(0.471)GQPPGQPSAPSQLSAPR 118.08 1.0517e-08 244909700.0 109293.6 84153.0 135739.5 114632.4 136718.8 99062.4 114007.9 122443.7 108725.7 94400.1 True False 103219.49924894578 90607.26450545662 127006.16835199314 99019.26936808022 119542.96206242015 112707.34640106719 119309.49325236821 122799.99089535429 130473.87804988175 91674.52383208461 1.12593439195831 0.9883581688563463 1.3854030873901635 1.0801176295112107 1.303993269508339 1.2294293080540815 1.3014465553254588 1.3395214478591735 1.4232294054656218 1.0 16.484233246983536 -5.151436790434681 0.8633256244280539 1.2795474130459177 1.003844950571701 0.16106399183751796 0.13804366664472525 2.254026575484992 1.8942259398468966 0.05031559484203524 0.5301919737159886 7.056075345102658e-06 5.151436790434681 -0.2757024624742166 SPSPPTQHT(ph)GQPPGQPSAPSQLSAPR ddPTM_A459_Selumetinib_30min_R1 1 SPSPPTQHTGQPPGQPSAPSQLSAPR 26 0 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7;Q68EM7-2;I3L460 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 S(0.001)PS(0.004)PPT(0.081)QHT(0.913)GQPPGQPSAPSQLSAPR 102.92 1.0284e-06 4708700.0 394.54 353.82 549.56 421.38 456.54 357.7 389.55 453.11 261.74 357.85 True False 403.7320143587995 312.39458991354473 474.93277051699835 347.79389328224545 415.2460376086836 354.1018627656143 360.16592987149556 441.0920508912924 444.1536632667604 403.78353325417805 0.9998724096176896 0.7736684737881453 1.1762063863511554 0.8613374856554944 1.028387745934379 0.8769596419938959 0.8919777559249163 1.0923973232301898 1.0999796343531665 1.0 8.657438266920241 -7.770220292160181 24.95624286479312 1.0721413989112276 0.9439149766721929 0.2093601887672002 0.1065829523657447 277.5562643757778 788828.5020658651 0.05414663333347314 0.026634962106751238 1.6973824513358926e-08 7.770220292160181 -0.1282264222390347 SPSPPTQHT(ph)GQPPGQPSAPSQLSAPR ddPTM_A459_Selumetinib_30min_R2 1 SPSPPTQHTGQPPGQPSAPSQLSAPR 26 0 Q68EM7-5;Q68EM7-3;Q68EM7-6;Q68EM7;Q68EM7-7;Q68EM7-2;I3L460 Q68EM7-5 ARHGAP17 Rho GTPase-activating protein 17 1 S(0.003)PS(0.003)PPT(0.052)QHT(0.941)GQPPGQPSAPSQLSAPR 99.097 3.3874e-06 93216000.0 6458.2 6604.4 9896.2 15277.0 15944.0 8132.7 8618.8 9513.2 9141.0 12957.0 True False 6099.279098222969 7110.936243506931 9259.489266167868 13196.246245705066 13940.972178831502 9252.905603699879 9019.591277828207 9540.881837004967 10969.45542087994 12582.897743671021 0.48472770123962905 0.5651270787036006 0.7358789250930081 1.0487446146768973 1.1079301813323221 0.7353557020165669 0.7168135243223211 0.7582420227331073 0.8717749793681178 1.0 13.61917658149731 -5.361674234104883 3.0328158872991926 0.8768388373746357 0.5140739583901736 0.5618624883830678 0.1278896546849711 0.215454698725098 3.7554905600617143 0.039057010684684354 0.09885853073672958 4.348362741661259e-06 5.361674234104883 -0.3627648789844622 SPSQPGQSGLCGVAAAATGHT(ph)PPLAEAPK ddPTM_A459_Selumetinib_30min_R2 1 SPSQPGQSGLCGVAAAATGHTPPLAEAPK 29 0 Q6AWC2-3;Q6AWC2-2;Q6AWC2-4;Q6AWC2;Q6AWC2-6;Q6AWC2-5 Q6AWC2-3 WWC2 Protein WWC2 1 SPSQPGQSGLCGVAAAAT(0.043)GHT(0.957)PPLAEAPK 108.1 1.6761e-10 6015300.0 25677.0 21453.0 25700.0 28665.0 28849.0 24604.0 29181.0 28497.0 22427.0 26648.0 True False 24249.975133175067 23098.37611773273 24046.489980044284 24760.77755011689 25224.730706667706 27992.977667125546 30537.974321054528 28579.921552067688 26913.026662736534 25878.603000181018 0.9370666234574347 0.8925665777851748 0.9292035578534159 0.9568050311658512 0.9747330915231885 1.0817035860448008 1.1800472506510848 1.1043842494847105 1.0399721601103538 1.0 14.659472118243484 -6.6409586118127555 2.547157657391951 1.0956509275866853 0.9272660894703051 0.7058849739066637 0.04654969040021781 0.1488087398090601 1.963284165207339 0.017366111856687155 0.017283781005214494 2.2858166309160825e-07 6.6409586118127555 -0.16838483811638016 SPSS(ph)DLDTDAEGDDFELLDQSELSQLDPASSR ddPTM_A459_Selumetinib_30min_R1 2 SPSSDLDTDAEGDDFELLDQSELSQLDPASSR 32 0 K7EQI9;Q86VR2-2;Q86VR2 K7EQI9 FAM134C Protein FAM134C 1 S(0.152)PS(0.152)S(0.695)DLDTDAEGDDFELLDQSELSQLDPASSR;S(0.169)PS(0.169)S(0.662)DLDTDAEGDDFELLDQSELSQLDPASSR 247.6 5.445399999999998e-75 6925400.0 266.62 375.942 410.57000000000005 255.21 199.64 144.31 353.446 263.15999999999997 0.0 125.93 True False 272.8317272477901 331.9265358693059 354.8168490995777 210.64236438502496 181.58259724930474 142.8583724229964 326.78528365899297 256.18014193584895 0.0 142.09434216207538 1.920074530037187 2.335958848317159 2.4970512104899094 1.482412045264705 1.2779016707237247 1.0053769224678177 2.299776885460054 1.802887701493739 0.0 1.0 7.150705301025231 -6.174518437702634 0.3065605857148515 0.8341198146267415 2.6950791496821296 0.357566843343355 0.5866143896386825 4.102586398065497 0.6078506222109984 0.786195714423992 2.7139512365225995 6.690854138369804e-07 6.174518437702634 1.8609593350553881 SPSSES(ph)SPQHPTPPARPR ddPTM_A459_Selumetinib_30min_R2 1 SPSSESSPQHPTPPARPR 18 1 O14733;O14733-4;O14733-3;O14733-2 O14733 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 1 S(0.063)PS(0.083)S(0.083)ES(0.441)S(0.328)PQHPT(0.001)PPARPR 105.01 0.00096912 2298100.0 554.61 523.46 1707.6 2306.3 3732.2 1404.4 2364.3 4487.4 2229.6 2128.0 True False 523.7869964797376 563.6076988108134 1597.7348750943054 1992.177961410591 3263.327669708666 1597.8433521261234 2474.244634771573 4500.457591070941 2675.5823002290676 2066.5591107919995 0.25345851166047634 0.27272759625772974 0.7731377567428888 0.9640072480903281 1.5791116995719567 0.7731902483610822 1.1972774559655979 2.1777541070897124 1.2947039773779627 1.0 11.013014915070322 -5.523472080457581 0.8087874657777882 1.4229782289724178 6.6078431215586944e-15 0.5761373956340143 0.3584046129108531 0.7858041446853647 0.7785808631009595 0.1617167923881312 0.8364442692550356 2.995904184295669e-06 5.523472080457581 -1.422978228972411 SPSSESS(ph)PQHPTPPARPR ddPTM_A459_Selumetinib_30min_R1 1 SPSSESSPQHPTPPARPR 18 1 O14733;O14733-4;O14733-3;O14733-2 O14733 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 1 S(0.002)PS(0.008)S(0.032)ES(0.171)S(0.703)PQHPT(0.085)PPARPR 122.83 0.00049545 2225400.0 144.98 286.7 246.14 207.56 361.22 289.64 349.25 275.58 200.63 227.32 True False 148.35775191802796 253.13303071678592 212.71553995024001 171.31354238374584 328.5477147785709 286.72648457207856 322.905791317212 268.2707231900031 340.4544565645681 256.4987362843083 0.5783956446225345 0.9868782762196858 0.829304436472786 0.6678923446775135 1.2808940875810089 1.117847552489558 1.258898176244022 1.0458949119057122 1.3273143622321852 1.0 8.002807907767473 -6.262593560409144 24.99985206286969 1.1757594009941084 0.7859710524940495 0.6732675103868269 0.13831698225039205 61.83621526158337 1339385.9600578719 0.03985831489684124 0.047783007091065546 5.462688540665594e-07 6.262593560409144 -0.38978834850005883 SPSSQETHDS(ph)PFCLR ddPTM_A459_Selumetinib_30min_R2 1 SPSSQETHDSPFCLR 15 0 Q8TB45-2;Q8TB45 Q8TB45-2 DEPTOR DEP domain-containing mTOR-interacting protein 1 SPSSQET(0.001)HDS(0.999)PFCLR 94.313 0.0076541 3673600.0 22938.0 33033.0 28375.0 27216.0 26239.0 19087.0 23397.0 21692.0 18294.0 25102.0 True False 21663.197788089336 35566.52488216406 26549.383392364092 23509.133849781287 22942.62224036378 21716.060995465188 24485.006860275953 21755.120128696075 21953.311177067895 24377.24003717143 0.8886649085399492 1.4590054012648992 1.0891053848540888 0.9643886598291515 0.9411492935779406 0.8908334562219363 1.004420796732534 0.892435734952889 0.9005659026039279 1.0 14.573247174495112 -5.655080343386815 3.75251129563287 0.9371395255991157 1.1935991950303793 0.33140953082300917 0.1341217981697399 0.21227271503880077 5.633729647003651 0.034882662507476424 0.06342737459956568 2.2126853305189533e-06 5.655080343386815 0.2564596694312635 SPT(ph)GPSNSFLANMGGTVAHK ddPTM_A459_Selumetinib_30min_R2 4 SPTGPSNSFLANMGGTVAHK 20 0 H0Y6J6;Q5W012;Q96I25 H0Y6J6 RBM17 Splicing factor 45 1 S(0.373)PT(0.485)GPS(0.132)NS(0.01)FLANMGGTVAHK;S(0.404)PT(0.544)GPS(0.026)NS(0.026)FLANMGGTVAHK;S(0.399)PT(0.529)GPS(0.071)NSFLANMGGTVAHK;S(0.347)PT(0.478)GPS(0.16)NS(0.015)FLANMGGTVAHK 163.6 4.2978e-07 556099500.0 471305.0 400944.1 480360.0 542384.0 593530.0 455132.0 457755.0 532319.0 471046.0 472941.0 True False 445111.7548834001 431695.2232315221 449454.16057642316 468510.3635354133 518965.4551744774 517822.30172306125 479041.51452432445 533867.9601598451 565268.3621249122 459285.96448171104 0.9691385962244545 0.9399268791474519 0.978593284651355 1.0200842171698228 1.1299397223255292 1.1274507426052232 1.0430136158523957 1.1623868383661524 1.230754705867833 1.0 18.80903317072803 -6.043298928484361 2.2442474051800607 1.1215959218543687 0.9579060961649646 0.5741713071796686 0.059759067162477995 0.21765158816136163 2.1816421232449286 0.019107393476924063 0.02865994125304423 9.051093921612871e-07 6.043298928484361 -0.16368982568940416 SPT(ph)KGEDWETLK ddPTM_A459_Selumetinib_30min_R2 1 SPTKGEDWETLK 12 1 Q4KWH8-2;A0A2U3TZV8;Q4KWH8 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 S(0.174)PT(0.826)KGEDWETLK 95.094 0.025406 6820200.0 46981.0 39125.0 46544.0 45443.0 42829.0 40366.0 48018.0 49357.0 38129.0 48594.0 True False 44369.98409984413 42125.76169329666 43549.40971327556 39253.58500645253 37448.438123882 45926.050093935555 50250.93214586189 49500.62069850876 45755.86541327333 47190.96495762524 0.9402220136775293 0.892665825569008 0.9228336346243484 0.8318029741858421 0.7935510146382583 0.9731958254122265 1.0648422254341339 1.0489427529815816 0.9695895274521182 1.0 15.526223051455384 -6.964293299483211 7.650655571325786 1.0241988695439164 0.8774541633251596 0.6909093608409516 0.046040353128221495 0.1250143344065919 22.063898851650386 0.017386216311329205 0.015231842704549206 1.0856921570121867e-07 6.964293299483211 -0.1467447062187568 SPT(ph)MEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R1 1 SPTMEQAVQTASAHLPAPAAVGR 23 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.138)PT(0.862)MEQAVQTASAHLPAPAAVGR 140.56 4.3234e-06 45624000.0 1882.5 2528.5 2744.8 2765.4 1960.6 2154.4 2458.4 2229.5 1275.1 1793.0 True False 1926.358587292644 2232.46204453224 2372.0712361071696 2282.4748029871403 1783.264076172045 2132.728692038689 2272.9609087308054 2170.3664175633635 2163.751570380706 2023.1490152989852 0.9521585274864011 1.1034590273135771 1.1724649139384427 1.1281792817667617 0.8814299207260867 1.0541629291322914 1.1234767639668413 1.0727664651249735 1.0694968853102214 1.0 10.982386870359244 -10.524127719136981 4.740924130219373 0.9999988041976605 1.0649624543032532 0.047887677551385566 0.08189387452748892 1.0801014007394297e-06 2.2754367448919985e-07 0.08273544616003241 0.020065923871784914 2.991384788294565e-11 10.524127719136981 0.06496365010559269 SPT(ph)PPPTLHLVPEPAAPPPPPPR ddPTM_A459_Selumetinib_30min_R2 1 SPTPPPTLHLVPEPAAPPPPPPR 23 0 A0A087WWH3;Q9NZM4-2;Q9NZM4 A0A087WWH3 GLTSCR1 Glioma tumor suppressor candidate region gene 1 protein 1 S(0.45)PT(0.519)PPPT(0.03)LHLVPEPAAPPPPPPR 74.905 0.0012863 10631000.0 27960.0 23569.0 23872.0 26665.0 34867.0 22642.0 19370.0 22538.0 23600.0 23968.0 True False 26406.09513274819 25376.66651372035 22336.101509868367 23033.18100030932 30486.69574506511 25760.72997638827 20270.74338092685 22603.581848633246 28320.65943909492 23275.981563657253 1.1344782629480272 1.090251186370721 0.9596201753632423 0.9895686219425849 1.309792055887626 1.1067516059821367 0.8708867261081383 0.9711118642543574 1.2167331960476524 1.0 14.506554388027883 -10.781626362856505 5.971819219932049 0.9999975270544941 1.066045980018302 0.02758553250747331 0.12382223662993166 4.267929621393685e-06 5.299161621800093e-07 0.1255096398141469 0.030439419078910394 1.6533836442398142e-11 10.781626362856505 0.0660484529638079 SPT(ph)SPLNMK ddPTM_A459_Selumetinib_30min_R2 2 SPTSPLNMK 9 0 A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 A0A0A0MRP6 SMARCA1 Probable global transcription activator SNF2L1 1 S(0.003)PT(0.681)S(0.316)PLNMK;S(0.004)PT(0.947)S(0.048)PLNMK 119.53 0.016062 129342000.0 653540.0 631300.0 714120.0 701670.0 699770.0 555760.0 586940.0 606070.0 547920.0 652870.0 True False 617218.8631279056 679718.6800505613 668174.296675066 606101.3355517363 611858.6365768271 632310.8953130259 614233.872999546 607833.5633597098 657519.3101639373 634019.9467400246 0.9735007018335842 1.0720777533033596 1.05386951958003 0.9559657210599777 0.9650463518109399 0.9973044200962663 0.9687926636343008 0.9586978556195924 1.0370640758934173 1.0 19.27416870377663 -5.756481643059151 24.999980922991192 0.9807689389119212 1.037042173635417 0.3212140639018545 0.03294470612138407 128.7270439639429 649112.0157500765 0.008809333261862099 0.014666582099333594 1.751936484227807e-06 5.756481643059151 0.05627323472349577 SPT(ph)SSVATPSSTISTPTKR ddPTM_A459_Selumetinib_30min_R2 1 SPTSSVATPSSTISTPTKR 19 1 A0A2R8YE27;A0A2R8YE71;A0A2R8Y7K8;A0A2R8Y5S6;A0A2R8Y622;A0A2R8YGJ7;A0A2U3TZH5;A0A2R8Y700;A0A2R8Y7A1;A0A2R8YED7;Q8WXI2-4;Q8WXI2-2;Q8WXI2-5;Q8WXI2 A0A2R8YE27 CNKSR2 Connector enhancer of kinase suppressor of ras 2 1 S(0.141)PT(0.859)SSVATPSSTISTPTKR 117.53 0.00057225 15025000.0 20468.0 17823.0 18581.0 21833.0 22526.0 17212.0 16824.0 14401.0 16696.0 19509.0 True False 19330.470499895902 19189.966790022416 17385.518689463155 18859.30773597424 19696.082495004917 19582.796765020525 17606.349336123556 14442.904525786109 20035.66652521731 18945.724479530607 1.020307801941329 1.0128916849158074 0.9176486604271515 0.9954387205593677 1.0396056649237675 1.0336261770394806 0.9293046225361219 0.7623305480553437 1.057529710561573 1.0 14.209584688730546 -7.354631175115349 6.596322467394216 0.9163123444077724 1.0009355060362966 0.12577080648466432 0.07796148471340354 0.4050641437606053 24.24615807663979 0.03217443685504558 0.02155116405754492 4.419456106378684e-08 7.354631175115349 0.08462316162852412 SPTAALNES(ph)LVECPK ddPTM_A459_Selumetinib_30min_R1 3 SPTAALNESLVECPK 15 0 Q53EZ4 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 SPTAALNES(1)LVECPK;SPT(0.001)AALNES(0.999)LVECPK;SPTAALNES(1)LVECPK 142.74 0.00038021 25798100.0 7366.6 9214.9 9275.2 10052.5 8159.7 8920.8 8815.4 8793.8 5100.6 6784.499999999999 True False 7538.227447091635 8136.015224109209 8015.678785026685 8297.019583795553 7421.656575712044 8831.06485143833 8150.447280680745 8560.559857711913 8655.345666915402 7655.356661626298 0.9846997050938474 1.0627872199465622 1.0470679733586494 1.083818814789609 0.9694723451507213 1.1535798058509092 1.064672443223471 1.118244418398308 1.1306260504231904 1.0 12.902253878843435 -6.767714113072987 24.999981965176254 1.0990178013953842 1.0354006769638555 0.2791723746808895 0.050475241880727224 196.66424636193338 783549.4111252307 0.016628383217139574 0.015029407938008986 1.707205836902345e-07 6.767714113072987 -0.06361712443152867 SPTAALNES(ph)LVECPK ddPTM_A459_Selumetinib_30min_R2 2 SPTAALNESLVECPK 15 0 Q53EZ4 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 SPTAALNES(1)LVECPK;SPTAALNES(1)LVECPK 149.3 0.00028795 14690400.0 62226.0 55072.0 62764.0 70387.0 68273.0 56819.0 51934.0 52805.0 47199.0 61137.0 True False 58767.72803041447 59295.845315609855 58725.83257227624 60800.16917565238 59695.93537163601 64645.30149847207 54349.03390526869 52958.65380766168 56640.118850247534 59371.81595699741 0.9898253419262016 0.9987204258424135 0.9891196963692495 1.024057765382981 1.0054591460512738 1.0888213617264833 0.9154012392788072 0.8919830554958814 0.9539900024495053 1.0 15.857490619859808 -7.292603609531417 24.999572698457776 0.9313421481239333 1.0138803878398222 0.48451259886949827 0.03773895772394855 547.2258550215403 438975.91717600514 0.015591523266664511 0.010513267788884053 5.0979596116466694e-08 7.292603609531417 0.0825382397158888 SPTAPSVFS(ph)PTGNR ddPTM_A459_Selumetinib_30min_R2 2 SPTAPSVFSPTGNR 14 0 H0Y3X6;A0A0C4DFX9;Q9H3P2;C9JEM7;H7C2C7;C9JHL4 H0Y3X6 NELFA Negative elongation factor A 1 SPTAPSVFS(0.692)PT(0.307)GNR;SPTAPS(0.005)VFS(0.923)PT(0.073)GNR 152.11 0.00038894 32168000.0 46331.0 39555.0 49361.0 52010.0 58107.0 42477.0 46027.0 37388.0 35102.0 42521.0 True False 43756.108497688 42588.74131062874 46185.16700019325 44926.14827774564 50807.07917682905 48327.82118218549 48167.34670077025 37496.792890083394 42123.38083182671 41293.30824717417 1.0596416309338055 1.03137150106018 1.1184661379935292 1.087976482989107 1.2303949800463356 1.170354791941203 1.1664685816028433 0.9080597918102 1.0201018668614266 1.0 15.333620385387324 -7.756147801234279 24.999985020191573 0.973060614287872 1.1243302460129536 0.5557020239714665 0.06040637913148501 100.88398474303052 476631.6383110218 0.03221703646250912 0.017895245852485888 1.753283714159046e-08 7.756147801234279 0.15126963172508157 SPTGPS(ph)NSFLANMGGTVAHK ddPTM_A459_Selumetinib_30min_R1 1 SPTGPSNSFLANMGGTVAHK 20 0 H0Y6J6;Q5W012;Q96I25 H0Y6J6 RBM17 Splicing factor 45 1 S(0.266)PT(0.315)GPS(0.374)NS(0.044)FLANMGGTVAHK 81.553 0.0068408 18901000.0 1730.0 2286.1 2367.4 2185.3 2105.5 2172.0 2308.5 2094.1 907.16 2051.1 True False 1770.30563400599 2018.4423492209444 2045.920083197362 1803.6783781614943 1915.0578967562165 2150.1516520182117 2134.3679864159863 2038.557665404549 1539.3842636550548 2314.3786644058823 0.7649161570803023 0.8721314192287082 0.8840040373093244 0.7793358994797472 0.8274609190833625 0.9290405606855052 0.9222207321738743 0.8808228734375502 0.66513932543974 1.0 11.176409213311116 -6.634383956227605 16.84611340761864 0.8750989510699282 0.828772615666418 0.08522429108169294 0.08735104352227253 3.7302788783603944 543.7861988740729 0.028844664949252124 0.02884427267242156 2.3206841910815578e-07 6.634383956227605 -0.046326335403510166 SPTLSQVHS(ph)PLVTSPSANLK ddPTM_A459_Selumetinib_30min_R2 2 SPTLSQVHSPLVTSPSANLK 20 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 S(0.001)PT(0.003)LS(0.007)QVHS(0.989)PLVTSPSANLK;SPTLSQVHS(1)PLVTSPSANLK 147.0 1.4985999999999997e-05 15337700.0 64873.0 66567.0 77744.0 110531.0 115152.0 63540.0 65539.0 73144.0 68997.0 78047.0 True False 61267.618367195006 71672.47485335916 72742.03568126689 95476.48712339003 100685.57628805844 72292.0582413086 68586.69336306475 73356.83693035896 82798.32793725556 75793.58031954092 0.808348386616579 0.9456272490518663 0.9597387453474435 1.2596909490337733 1.3284182626493488 0.9538018647031828 0.9049142826332732 0.9678502667520282 1.092418745600657 1.0 16.209788037531837 -5.119867306348744 2.074219438747972 1.0679720637493166 0.8207234132877904 0.2737030700631179 0.12994221558361851 0.603602550406421 4.408775116209438 0.040545473361506004 0.21441630067885495 7.588093850370508e-06 5.119867306348744 -0.24724865046152622 SPTLSQVHSPLVT(ph)SPSANLK ddPTM_A459_Selumetinib_30min_R2 1 SPTLSQVHSPLVTSPSANLK 20 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 SPTLSQVHS(0.001)PLVT(0.702)S(0.296)PS(0.001)ANLK 119.25 0.00034613 41349000.0 61866.0 53923.0 93681.0 101390.0 92944.0 81472.0 75624.0 64398.0 70568.0 79740.0 True False 58427.73538922029 58058.720710227106 87653.66645216077 87580.50709249426 81267.5437900976 92694.02847081996 79140.66584611314 64585.38751833718 84683.57183466326 77437.69901059858 0.7545128036568277 0.7497474931722965 1.1319249870810855 1.130980235873324 1.0494571097596126 1.1970142405462398 1.021991444183814 0.8340303023401773 1.0935703528984375 1.0 16.240748464453823 -5.252985473829935 24.698632203209485 1.0575135488341119 0.7521300884817728 0.6333898644123219 0.09289004950281483 348.2904084950001 1017546.1922879561 0.025458355613327537 0.06500296215807704 5.584888746165801e-06 5.252985473829935 -0.3053834603523391 SPTS(ph)PLNMK ddPTM_A459_Selumetinib_30min_R1 1 SPTSPLNMK 9 0 A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 A0A0A0MRP6 SMARCA1 Probable global transcription activator SNF2L1 1 S(0.004)PT(0.193)S(0.803)PLNMK 97.734 0.020328 72407000.0 4536.3 5204.6 5599.9 6046.7 5409.9 4734.4 4824.1 5115.5 2643.4 3580.3 True False 4641.9869638967475 4595.243012447102 4839.464338048872 4990.757355616672 4920.575500195419 4686.7762344912635 4460.2142530948095 4979.82032251419 4485.656733702738 4039.8663800752674 1.149044678009935 1.1374740103066199 1.1979268329064654 1.2353768382615882 1.2180045172938971 1.1601314978155153 1.104049944595373 1.2326695623089914 1.1103477966068682 1.0 11.980091860809763 -8.559110467093085 5.761884075571514 1.0000186102025865 1.1783504702812648 0.6499615683855213 0.040684258593658255 0.1599588777601191 21.530026819759943 0.04146191473846685 0.010753298161131946 2.759875765258802e-09 8.559110467093085 0.1783318600786783 SPTTVLFTS(ph)SPIK ddPTM_A459_Selumetinib_30min_R1 1 SPTTVLFTSSPIK 13 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 SPTTVLFT(0.041)S(0.479)S(0.479)PIK 203.74 5.1593e-05 14654000.0 1743.4 2330.6 1738.4 1699.9 1517.7 1772.5 1747.9 1604.8 912.41 2028.9 True False 1784.0178279341292 2057.7322685334543 1502.334828347678 1403.0443760750131 1380.424302971698 1754.6702593012333 1616.054495757637 1562.2354908749437 1548.293130210226 2289.329078159569 0.7792753977371973 0.8988363831851124 0.6562336724239884 0.6128626895365104 0.6029820335316078 0.7664561098013235 0.7059074692122511 0.6823988328191122 0.6763086814303366 1.0 11.16070914174758 -10.119764011606103 6.106347655748447 0.9999999999005835 0.7079253238153687 0.5235202605584665 0.08327126127326834 32990407.725900926 54673459.53912273 0.18643251107729675 0.022070251699225423 7.589898854703074e-11 10.119764011606103 -0.29207467608521487 SPTTVLFTSS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 1 SPTTVLFTSSPIK 13 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 SPTTVLFT(0.004)S(0.132)S(0.864)PIK 206.45 1.2293e-05 13468000.0 3031.7 3197.3 3460.1 3542.9 2714.1 2586.7 3215.9 2972.7 1772.1 2604.2 True False 3102.3327113387045 2822.958629615556 2990.237424968823 2924.1990234697105 2468.610134213274 2560.6801465356857 2973.3220738640557 2893.854339309539 3007.1242709369058 2938.4744370561166 1.055763042283515 0.960688510342704 1.017615599189818 0.9951418962825119 0.8400992375779958 0.8714318267478547 1.0118590913599543 0.9848152166362625 1.0233624063612972 1.0 11.520851632472226 -10.724949525924544 17.29960882516849 0.9999999999832432 0.9695288781907166 0.01181664913998659 0.06463859049277532 0.0 0.0 0.06732663883900912 0.01632910843241453 1.8838680215170935e-11 10.724949525924544 -0.030471121792526534 SPTTVLFTSS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 2 SPTTVLFTSSPIK 13 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 SPTTVLFT(0.048)S(0.295)S(0.657)PIK;SPTTVLFT(0.001)S(0.007)S(0.993)PIK 237.07 1.2925999999999999e-17 16700900.0 95570.0 80323.0 95237.0 103511.0 97928.0 78687.0 84392.0 80362.0 69628.0 93696.0 True False 90258.6019970222 86483.51582084762 89109.55510620536 89412.6232335653 85625.40915257222 89525.42000053271 88316.39521957551 80595.8401153548 83555.54556886875 90990.75302855595 0.9919535666299631 0.9504648872804272 0.9793253945072835 0.9826561519444138 0.9410341853715629 0.9838958028233554 0.9706084660257606 0.8857585791169476 0.9182861201582343 1.0 16.473432317853174 -7.697404095107351 21.941112741870057 0.9265169196782923 0.9706616810813467 0.22118277717745294 0.03043331578376795 22.819969434807312 7818.300318544708 0.013489753800143174 0.007788286546565618 2.0072242947674974e-08 7.697404095107351 0.044144761403054344 SPVAEEPGGGGSSSSEAKLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SPVAEEPGGGGSSSSEAKLSPR 22 1 Q7L8J4 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 SPVAEEPGGGGSS(0.003)S(0.008)S(0.023)EAKLS(0.966)PR 86.99700000000001 0.00030675 17760000.0 3087.7 3453.4 2176.8 2019.2 3892.8 2226.8 3930.8 3263.7 1227.0 3054.9 True False 3159.6374023816743 3049.0743225578963 1881.2025163065039 1666.5846250783363 3540.6969273296627 2204.400413772632 3634.2965912947657 3177.1360740083232 2082.1293834657104 3447.026172245883 0.9166270415414447 0.8845521241201646 0.5457465137495086 0.48348476100849735 1.02717436723805 0.6395078840774719 1.0543281105773756 0.9217034960713063 0.6040364300770932 1.0 11.751136537363788 -6.276733871279779 24.986132637495253 0.8677895022821146 0.7086806866218127 0.15835188237931608 0.18806859003337456 1693.5958712060528 2766767.8114899453 0.06003245116021353 0.06831462522804503 5.287691738200168e-07 6.276733871279779 -0.15910881566030188 SPVAEEPGGGGSSSSEAKLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SPVAEEPGGGGSSSSEAKLSPR 22 1 Q7L8J4 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 SPVAEEPGGGGSSSSEAKLS(1)PR;SPVAEEPGGGGS(0.024)S(0.027)S(0.102)S(0.231)EAKLS(0.616)PR 96.41 0.00010984 18934900.0 40881.0 35424.0 36952.0 40979.0 46035.0 35960.0 40338.0 34997.0 37660.0 36969.0 True False 38608.99767960939 38140.90689388731 34574.54855029559 35397.58950728202 40251.671741878345 40913.163587621304 42213.79692823063 35098.83547593478 45193.052308318416 35901.60891300256 1.07541134920074 1.0623731929761437 0.9630361868761168 0.9859610914111987 1.1211662362936696 1.1395913672493854 1.1758190846132797 0.977639625037054 1.2588029806082244 1.0 15.131760878717502 -6.272734483904094 24.090056752078794 1.1156054055928297 1.0204110613218524 0.22761712368095444 0.08148691907222592 639.6558649153261 1364247.146636232 0.024217430547349334 0.027721740402024252 5.336610619529427e-07 6.272734483904094 -0.09519434427097728 SPVDES(ph)GDEVQYGDVPVENGMAPFFEMK ddPTM_A459_Selumetinib_30min_R1 2 SPVDESGDEVQYGDVPVENGMAPFFEMK 28 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;F8WA26;D6R9F5 Q8WX93 PALLD Palladin 1 S(0.035)PVDES(0.965)GDEVQYGDVPVENGMAPFFEMK;S(0.075)PVDES(0.925)GDEVQYGDVPVENGMAPFFEMK 69.551 0.006910899999999999 0.0 584.0 741.8299999999999 862.27 761.36 717.6 675.16 612.4300000000001 672.4 427.03 408.95000000000005 True False 597.606063733814 654.9761987325893 745.1784701100734 628.4027684972478 652.6932067025701 668.368503396232 566.2339120297786 654.5657677369846 724.6387209628056 461.4427160103288 1.2950818010538006 1.4194095518411618 1.6148883583057654 1.3618218398384727 1.414462042755401 1.4484322326615107 1.227094701863501 1.4185201001684746 1.5703763345276978 1.0 8.850007751064357 SPVDES(ph)GDEVQYGDVPVENGMAPFFEMK ddPTM_A459_Selumetinib_30min_R2 1 SPVDESGDEVQYGDVPVENGMAPFFEMK 28 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;F8WA26;D6R9F5 Q8WX93 PALLD Palladin 1 S(0.011)PVDES(0.988)GDEVQY(0.001)GDVPVENGMAPFFEMK 105.71 8.017300000000001e-10 3575200.0 7462.0 8326.8 7236.6 8693.1 7166.5 6376.3 4888.1 8466.2 4681.5 8798.8 True False 7047.291912752751 8965.43878511802 6771.005034614339 7509.084783566058 6266.180200677116 7254.577446711613 5115.4063355864 8490.83524034514 5617.930812039107 8544.755781972106 0.8247505361851613 1.0492328878530945 0.7924164490341478 0.8787945466398084 0.7333363715201348 0.849009337635777 0.5986603322682417 0.9936896333841714 0.6574711969992083 1.0 13.060823543424508 -5.296145184341336 24.54679638236423 0.8058436890391055 0.9369917918288845 0.12116018992727329 0.13256733707287713 783.9834931315844 554496.0399884306 0.03180013542026003 0.06620197421561376 5.056555934339615e-06 5.296145184341336 0.13114810278977895 SPVGKS(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R1 2 SPVGKSPPSTGSTYGSSQK 19 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.002)PVGKS(0.886)PPS(0.088)T(0.021)GS(0.001)T(0.001)YGSSQK;S(0.001)PVGKS(0.893)PPS(0.076)T(0.026)GS(0.003)T(0.001)YGSSQK 102.19 0.00061185 69614000.0 9838.8 12670.7 9180.3 9759.6 9412.9 9089.8 11074.9 9189.3 5104.07 8758.0 True False 10068.024897027815 11187.20855355138 7933.665683778297 8055.26907038161 8561.50485698247 8998.36486487805 10239.511376546856 8945.569912946861 8661.23400347663 9882.174610144177 1.0188066184028828 1.1320593892428867 0.8028258957936535 0.8151312224449844 0.8663583871705705 0.9105652571288425 1.0361597300695202 0.9052228143959449 0.8764502091053687 1.0 13.27061283194352 -5.253494840958573 24.918049632346722 0.8989849263282574 1.0754330115619017 0.474660397372604 0.07311457160853405 506.988656973872 1590160.7535582718 0.019804507276712787 0.050409051040797986 5.57834228688214e-06 5.253494840958573 0.1764480852336443 SPVGKS(ph)PPSTGSTYGSSQK ddPTM_A459_Selumetinib_30min_R2 1 SPVGKSPPSTGSTYGSSQK 19 1 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.08)PVGKS(0.68)PPS(0.107)T(0.107)GS(0.008)T(0.008)Y(0.008)GS(0.002)S(0.001)QK 52.91 0.038097000000000006 55764000.0 104590.0 75392.0 95753.0 100170.0 103100.0 74011.0 81588.0 80476.0 71557.0 95177.0 True False 98777.30650694326 81174.32397651194 89592.35622798374 86526.67319711162 90147.65627430569 84205.34344503446 85382.00366355492 80710.1718364809 85870.39946963219 92428.99271045609 1.0686831437877287 0.8782344326828203 0.9693101006590169 0.936142120126375 0.975317956311642 0.9110273841111403 0.9237578075855848 0.8732127168075317 0.9290418184976935 1.0 16.49605784026825 -6.768331928056616 24.970734136486964 0.9192556022404499 0.9592638848131102 0.09902785735684227 0.053155406660146155 348.8762037977328 1263920.3649608376 0.017461241939285777 0.015733407863574467 1.7047789410378227e-07 6.768331928056616 0.040008282572660314 SPVGKS(ph)PPSTGSTYGSSQKEESAASGGAAYTK ddPTM_A459_Selumetinib_30min_R1 1 SPVGKSPPSTGSTYGSSQKEESAASGGAAYTK 32 2 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.016)PVGKS(0.677)PPS(0.108)T(0.041)GS(0.041)T(0.041)Y(0.037)GS(0.016)S(0.016)QKEES(0.005)AAS(0.001)GGAAYTK 46.902 0.0072191999999999985 29600000.0 1639.7 2071.5 2443.6 2924.1 2598.0 2316.9 2095.6 2093.1 975.78 1685.7 True False 1677.901819699204 1828.967816985778 2111.772541733999 2413.4608271550933 2363.011358714153 2293.594089576885 1937.52720482276 2037.5841886530068 1655.8273918485506 1902.0760151084758 0.882142357282978 0.9615639976835897 1.1102461336770308 1.2688561382324424 1.2423327669054227 1.2058372385533083 1.0186381561161018 1.0712422492414442 0.8705369179233977 1.0 10.893359188288864 -7.926128124672933 2.039344802237279 0.9430063506575889 1.1136684209891405 0.2087749707324097 0.12040183010170045 0.5752664294082392 4.488801102005227 0.10784119703850333 0.03845971896726723 1.185418976684716e-08 7.926128124672933 0.17066207033155167 SPVGS(ph)GAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK ddPTM_A459_Selumetinib_30min_R2 1 SPVGSGAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK 51 0 P16989-2;P16989;P16989-3 P16989-2 YBX3 Y-box-binding protein 3 1 S(0.478)PVGS(0.522)GAPQAAAPAPAAHVAGNPGGDAAPAATGTAAAASLATAAGSEDAEK 65.988 8.006399999999999e-11 23660000.0 61287.0 37942.0 62833.0 54665.0 67565.0 61457.0 78620.0 82913.0 80802.0 59366.0 True False 57880.91389129959 40852.02939724119 58790.3931873978 47219.53269761516 59076.8806612363 69922.14389889997 82275.98578257457 83154.26310301392 96964.65779651479 57651.94932860805 1.0039714973276355 0.7085975387300495 1.019746840688782 0.8190448588038269 1.0247160997888614 1.2128322582876345 1.4271154183115815 1.4423495488252487 1.6818972979357525 1.0 15.815081768678375 -6.84988505210289 1.7929717167149386 1.4281513801489985 0.8833493075084407 0.612855079410423 0.17897873019609412 0.20898535752466949 1.3824891522125953 0.07315575477126482 0.06258133224753315 1.412911460747869e-07 6.84988505210289 -0.5448020726405578 SPVLSNTTTEPASTMS(ph)PPPAKK ddPTM_A459_Selumetinib_30min_R2 1 SPVLSNTTTEPASTMSPPPAKK 22 1 A0A075B784;Q9P275 A0A075B784 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 SPVLSNTTTEPAS(0.286)T(0.22)MS(0.493)PPPAKK 58.924 0.0093578 7991000.0 19554.0 17488.0 21650.0 22180.0 22379.0 14847.0 19448.0 18230.0 11404.0 18623.0 True False 18467.266960864017 18829.273367217193 20257.062570737704 19159.04573736587 19567.5499492016 16892.03948235299 20352.370535480906 18283.046281861025 13685.11865438298 18085.30560163506 1.0211199836841256 1.0411365880107037 1.120084062550002 1.0593708593806528 1.0819584905124595 0.9340201296253358 1.1253539743138699 1.0109337759937045 0.7566982253894418 1.0 14.142530356102071 -8.046440742551495 10.38187500941717 0.87981769867634 1.054361474669505 0.46579264384304153 0.0745055786643358 0.5940317022833935 130.13899694903753 0.04654319138502937 0.017711066096547042 8.98585191948326e-09 8.046440742551495 0.17454377599316495 SPVPSLRPSS(ph)TGPSPSGGLSEEPAAK ddPTM_A459_Selumetinib_30min_R2 1 SPVPSLRPSSTGPSPSGGLSEEPAAK 26 1 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 SPVPS(0.024)LRPS(0.305)S(0.459)T(0.19)GPS(0.011)PS(0.005)GGLS(0.006)EEPAAK 61.14100000000001 0.0026765 5525900.0 9026.9 9063.1 11451.0 9198.2 9137.4 7430.4 6375.0 8716.7 6501.2 7954.9 True False 8525.2210355438 9758.210627540375 10714.25512690612 7945.389292219954 7989.478122607569 8453.870153544534 6671.45013182285 8742.064153872638 7801.621658705246 7725.221367687631 1.103556860027641 1.2631625895351233 1.3869188489174893 1.0284998855117888 1.0342070139278141 1.0943207645679425 0.8635933928997296 1.1316263622474518 1.0098897219097405 1.0 12.915360558972221 -5.785858363755591 24.999644996939228 1.025423202710167 1.2524077057196694 0.5664660694930355 0.09140821711559352 155.9188102462429 159625.82121987332 0.02549544408828686 0.03783609974931929 1.637350422645461e-06 5.785858363755591 0.22698450300950235 SPVPSPGS(ph)SSPQLQVK ddPTM_A459_Selumetinib_30min_R1 2 SPVPSPGSSSPQLQVK 16 0 Q8N3F8 Q8N3F8 MICALL1 MICAL-like protein 1 1 SPVPSPGS(0.333)S(0.333)S(0.333)PQLQVK;SPVPSPGS(0.333)S(0.333)S(0.333)PQLQVK 209.23 5.615e-08 59387000.0 6249.9 6976.1 5766.8 6368.6 6216.299999999999 5286.1 6490.9 5415.9 3156.2 4913.0 True False 6395.510509811578 6159.334968899097 4983.70023476495 5256.4435634280435 5654.0367625769 5232.926633394781 6001.286187146428 5272.252738677474 5355.840880272593 5543.631406672569 1.1536680635212595 1.1110650252622205 0.8989955985829686 0.9481949967130114 1.0199157100833656 0.9439528441765068 1.0825550522574436 0.9510467691505514 0.966124997745351 1.0 12.436615621241888 -5.112095988353938 5.677561671560293 0.9781272661758252 1.1435520613030947 0.6370635764007415 0.047498205597079866 0.12992170752947885 5.520941748456113 0.01219710703854991 0.03407397168377543 7.725098250589432e-06 5.112095988353938 0.16542479512726949 SPVPSPGS(ph)SSPQLQVK ddPTM_A459_Selumetinib_30min_R2 4 SPVPSPGSSSPQLQVK 16 0 Q8N3F8 Q8N3F8 MICALL1 MICAL-like protein 1 1 SPVPSPGS(0.699)S(0.269)S(0.032)PQLQVK;SPVPS(0.015)PGS(0.868)S(0.059)S(0.059)PQLQVK;SPVPSPGS(0.633)S(0.079)S(0.288)PQLQVK;SPVPSPGS(0.576)S(0.212)S(0.212)PQLQVK 214.54 1.1638e-08 85327000.0 268616.0 242830.0 276182.0 282522.0 302284.0 230436.0 234022.0 239048.0 212717.0 274885.0 True False 253687.39807504593 261454.2801784855 258412.75080422568 244042.01622236596 264308.3814667528 262176.4673102643 244904.48670579598 239743.5901034731 255266.34380957426 266948.35581299727 0.9503238830688251 0.9794189568323827 0.968025257234583 0.9141918686074333 0.9901105427744465 0.9821243008288998 0.9174227200610913 0.8980897798502208 0.9562386815687807 1.0 18.026201137626387 -7.262940147843938 24.99719543634396 0.9344452774322698 0.9638332295423379 0.07023030232093253 0.03211881070759278 258.5997955874194 4307253.434261688 0.012786711222147886 0.009138448958466187 5.458330797205236e-08 7.262940147843938 0.02938795211006806 SPVSFSPTDHS(ph)LSTSSGSSIFTPEYDDSR ddPTM_A459_Selumetinib_30min_R1 1 SPVSFSPTDHSLSTSSGSSIFTPEYDDSR 29 0 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 S(0.009)PVS(0.023)FS(0.064)PT(0.188)DHS(0.581)LS(0.014)T(0.039)S(0.039)S(0.014)GS(0.016)S(0.007)IFT(0.004)PEYDDSR 50.088 0.01685 5228400.0 511.61 443.21 464.88 466.42 513.75 284.67 440.97 461.87 109.31 243.34 True False 523.5295175802336 391.31876715726077 401.7518494030537 384.9685027877567 467.2814032099294 281.80647825967964 407.7072778730162 449.619707234802 185.49108631347738 274.575059332323 1.9066899916302908 1.42517957788599 1.463176773520447 1.4020519697742195 1.7018348437990158 1.0263367654183198 1.484866392688496 1.6375110992532624 0.675556937926304 1.0 8.101056775887184 -1.5228787494616585 0.09395265229786803 0.6639989740666794 3.6179255282953426 0.39169104994611337 0.27385423993662106 163.57943314500443 1.1031186106775512 4.295705210166545 62.22610751841389 0.029999999711164585 1.5228787494616585 2.953926554228663 SPVVSGDTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SPVVSGDTSPR 11 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SPVVSGDT(0.004)S(0.996)PR;SPVVSGDT(0.29)S(0.71)PR 127.52 0.0029518 39239000.0 8844.5 7839.0 11946.900000000001 12206.900000000001 10188.5 9413.3 8413.900000000001 7482.4 5381.7 6581.5 True False 9050.559641598833 6921.206235747769 10324.57659962429 10075.194066892218 9266.95197392578 9318.610748592553 7779.232748930251 7283.942445739456 9132.351836183707 7426.299634238858 1.2187172733875893 0.9319858579147059 1.3902720208087167 1.3566910255601143 1.2478559215683431 1.2548121147212024 1.047524760927259 0.9808306699822525 1.2297311293607274 1.0 12.858427810480864 -7.262747051910825 24.70513091214921 1.0629241890376493 1.2330821600023012 0.2866312105341594 0.1305006105571417 144.25018921844372 2725195.0087190676 0.05505823771978942 0.03944928610326548 5.460758218845879e-08 7.262747051910825 0.1701579709646519 SPVVSGDTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SPVVSGDTSPR 11 0 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 1 SPVVS(0.001)GDT(0.195)S(0.804)PR 98.407 0.018278 42346000.0 170060.0 148760.0 178140.0 187000.0 229530.0 136930.0 127830.0 139220.0 121200.0 156200.0 True False 160608.74600411867 160169.41366120966 166678.66634416734 161530.27740700688 200694.38937576488 155790.86457321967 133774.3482903395 139625.10715088842 145443.38661094505 151690.1001436612 1.0587951741874446 1.0558989249101818 1.098810444361965 1.0648702667743402 1.3230552896048797 1.0270338303269282 0.8818924119876365 0.9204628846487254 0.9588192404988851 1.0 17.21076740748584 -6.999758330930308 24.99999970815998 0.9366366055015111 1.1186979538373056 0.5442980518666278 0.07768681978388617 6.6255768836092575 685314.0901564586 0.02830701037632281 0.024729835655199955 1.0005566184519005e-07 6.999758330930308 0.18206134833579457 SPYEAENS(ph)GEELDQR ddPTM_A459_Selumetinib_30min_R2 1 SPYEAENSGEELDQR 15 0 R4GMT1;Q9NPC7-3;Q9NPC7-2;Q9NPC7 R4GMT1 MYNN Myoneurin 1 S(0.445)PYEAENS(0.555)GEELDQR 146.67 0.00037203 0.0 3000.0 3122.7 3729.9 3956.7 4589.4 2833.6 4237.7 3127.4 3456.5 3827.2 True False 2833.272009951521 3362.201048936935 3489.922294808062 3417.7906343117884 4012.8385422434335 3223.902679140261 4434.761446843246 3136.50021623106 4147.896582679304 3716.6987917402 0.762308749971356 0.9046202658146304 0.9389844295598787 0.9195769756503568 1.079678167937999 0.8674102637278266 1.1931990444581713 0.843894109256703 1.1160163400643 1.0 11.859806058879876 -3.613750207897848 0.5713926602918404 1.0142371052033656 1.3080351551297652e-15 0.36045778892973557 0.10142743273864098 14.030122455941825 1.2512700120854146 0.04581789289228322 12.689777463901427 0.00024336033363305673 3.613750207897848 -1.0142371052033643 SPYGGGRPGR ddPTM_A459_Selumetinib_30min_R2 1 SPYGGGRPGR 10 1 P46781 P46781 RPS9 40S ribosomal protein S9 0 120.31 0.014455 5286400.0 1749.6 969.77 1359.8 1659.4 1561.9 623.35 1444.2 3473.7 1497.4 1196.2 False True 1652.364236203727 1044.1482406979762 1272.3119484382967 1433.3868573753346 1365.680158436838 709.210804292095 1511.35816162801 3483.8078918980063 1796.9218408517254 1161.6625978991501 1.422413219804101 0.8988395103589486 1.0952508505819627 1.233909794433938 1.1756254879055679 0.6105135911018331 1.301030234046684 2.9989842990541504 1.5468534874940731 1.0 10.181975386949121 -7.541782938783275 24.998872383372138 1.99375314943451 1.0677009887656892 0.30497552300266195 0.5100138856772648 229.7627381254634 303834.1681237235 0.22311102833330296 0.12883735578194874 2.872215762299991e-08 7.541782938783275 -0.9260521606688208 SPYGSRS(ph)PFEHSVEHK ddPTM_A459_Selumetinib_30min_R2 1 SPYGSRSPFEHSVEHK 16 1 O14646 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(0.004)PY(0.062)GS(0.079)RS(0.854)PFEHSVEHK 67.846 0.021148 11684000.0 49125.0 52558.0 63271.0 74288.0 83310.0 44654.0 34587.0 37029.0 29626.0 79748.0 True False 46394.82916295615 56589.02959939391 59200.212744256096 64169.846246052126 72843.8529991504 50804.683171347104 36195.364032840305 37136.74825951907 35552.0278196028 77445.46802981207 0.5990644816698222 0.7306951722160214 0.7644115821143648 0.8285810374514156 0.9405825137645201 0.6560058898706663 0.46736581175940684 0.4795212580447386 0.45905885423685877 1.0 16.24089319710251 -6.996420724912398 24.838037903340474 0.5586236084163938 0.7755140477534105 0.17320364605971916 0.1681194742427619 130.66410139381637 906720.550201488 0.057649682233697735 0.05059967091275132 1.0082756408183119e-07 6.996420724912398 0.21689043933701668 SPYGSRSPFEHS(ph)VEHK ddPTM_A459_Selumetinib_30min_R2 1 SPYGSRSPFEHSVEHK 16 1 O14646 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(0.007)PY(0.009)GS(0.011)RS(0.041)PFEHS(0.932)VEHK 53.038 0.043387 14877000.0 77614.0 71142.0 105620.0 107570.0 118040.0 73227.0 58046.0 49431.0 41134.0 103360.0 True False 73300.52459345905 76598.36264241548 98824.52419036081 92918.78043139975 103210.75990901105 83313.35456147786 60745.25401596696 49574.8360262574 49361.949379988604 100375.72823846863 0.7302614474618266 0.7631163826820381 0.984546024468958 0.9257096517461576 1.028244195287999 0.8300149450825934 0.60517871284232 0.49389266604850424 0.4917717683972012 1.0 16.61505092915042 -7.201098823739113 4.243459357930697 0.604316382326309 0.8898734763908628 0.32215394863910174 0.15913051458733474 0.22434902846314395 8.255720563197032 0.06362550769535424 0.047500079219752384 6.293629549785317e-08 7.201098823739113 0.28555709406455376 SPYHVRGPINQVCS(ph)EILLS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 SPYHVRGPINQVCSEILLSR 20 1 A4D0V7 A4D0V7 CPED1 Cadherin-like and PC-esterase domain-containing protein 1 2 SPYHVRGPINQVCS(1)EILLS(1)R 63.398 0.015589 45500000.0 1713.1 2419.6 2034.9 2242.6 2294.0 2025.3 1821.9 1751.9 1047.2 1429.3 True False 1753.0118968876645 2136.312107158477 1758.571756905596 1850.9720088157085 2086.508105038594 2004.9273208252682 1684.472616179894 1705.4339210268026 1777.021915538136 1612.76457756098 1.0869608133003417 1.324627373940262 1.0904082228573768 1.1477013040644624 1.2937462380244407 1.2431618034774579 1.0444628060515564 1.0574599323144662 1.1018483046208556 1.0 10.655320141894844 -7.269072720903914 24.829692761115364 1.0557310782755025 1.2007409278319303 0.4661240731702698 0.07687165317922146 506.6719126597597 1648093.6215719222 0.03148855871189678 0.021715612635844886 5.3817965890261536e-08 7.269072720903914 0.14500984955642782 SPYQEFTDHLVK ddPTM_A459_Selumetinib_30min_R2 2 SPYQEFTDHLVK 12 0 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 0 ; 130.69 0.0029958000000000003 4733800.0 42193.0 35678.0 42300.0 41844.0 45589.0 39228.0 34120.0 33807.0 32677.0 42541.0 False True 39848.08197196152 38414.387877148576 39578.46405275774 36144.77501507379 39861.702249168964 44631.30092367101 35706.64760749737 33905.37277294987 39213.31307166546 41312.73079520794 0.9645472764677101 0.9298438311321807 0.9580210092853177 0.8749064590827386 0.9648769636354494 1.0803280263634378 0.8643013163302957 0.8207003536276211 0.9491823057171035 1.0 15.334298805865316 SQAAPGSS(ph)PCR ddPTM_A459_Selumetinib_30min_R1 3 SQAAPGSSPCR 11 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 SQAAPGS(0.078)S(0.922)PCR;SQAAPGS(0.004)S(0.996)PCR;SQAAPGS(0.027)S(0.973)PCR 162.67 0.00056268 40830500.0 8669.63 10046.66 10137.52 10372.41 10244.720000000001 8469.810000000001 8565.98 7457.320000000001 4050.0 6893.93 True False 8871.615510836618 8870.392376634481 8760.90046541138 8561.063307749995 9318.086884852219 8384.61140137218 7919.841232089936 7259.527648810776 6872.554199703444 7778.8330680647705 1.1404815392244574 1.1403243004469397 1.1262486787868464 1.1005588155499304 1.1978772141424017 1.0778752195871606 1.0181271615924066 0.9332412182251407 0.8834942387333179 1.0 12.925338032009057 -7.374147962866269 1.9162831613592728 0.9311349557107994 1.1374257758381683 0.8467728678619044 0.03730735495790195 0.12046389025775325 0.8627097308322086 0.020093509295674144 0.011548856910054464 4.225246368263488e-08 7.374147962866269 0.20629082012736888 SQAAPGSS(ph)PCR ddPTM_A459_Selumetinib_30min_R2 6 SQAAPGSSPCR 11 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 SQAAPGS(0.119)S(0.881)PCR;SQAAPGS(0.205)S(0.795)PCR;SQAAPGS(0.029)S(0.971)PCR;SQAAPGS(0.035)S(0.965)PCR;SQAAPGS(0.049)S(0.951)PCR;SQAAPGS(0.094)S(0.906)PCR 143.58 0.00082779 177399880.0 114749.8 114783.09999999999 132343.3 132670.4 160179.0 115000.9 115761.4 117595.1 108033.09999999999 125849.3 True False 108372.46549584507 123586.59468416203 123828.47616249035 114600.46265079467 140055.88200157133 130841.23010076983 121144.53447686242 117937.2822720833 129642.73869702063 122215.70371324963 0.8867311008584915 1.0112169789091006 1.0131961147400885 0.9376901590296257 1.1459728802951499 1.0705762526864628 0.9912354206223739 0.9649928666188051 1.06076989092332 1.0 16.89907014595706 -4.748929369064193 3.8167867107931497 1.0232501237973823 0.8677870772218447 0.34694942235784987 0.05576466804737926 0.3570316738460945 8.922445295833295 0.014618149153009654 0.16379486567358087 1.7826686659459458e-05 4.748929369064193 -0.15546304657553767 SQANGAGALSYVS(ph)PNTSK ddPTM_A459_Selumetinib_30min_R1 3 SQANGAGALSYVSPNTSK 18 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;A0A494C002;A0A494C1N1;A0A494C0Q2;F5H1Z4;A0A494C1K5;A0A494C0P9;A0A494BZU6;A0A494C1G3;A0A494C156;A0A494BZW7 O95453 PARN Poly(A)-specific ribonuclease PARN 1 SQANGAGALS(0.062)YVS(0.85)PNT(0.078)S(0.01)K;SQANGAGALSYVS(0.998)PNT(0.001)SK;SQANGAGALSYVS(0.785)PNT(0.192)S(0.023)K 250.38 5.818299999999999e-33 65023000.0 10180.6 10504.900000000001 11677.7 11341.2 10228.8 9192.7 9389.0 9580.7 5824.610000000001 9271.060000000001 True False 10417.7881720008 9274.981424404488 10091.932481014537 9360.672320690595 9303.606846041319 9100.229784303785 8680.780170872733 9326.588713500478 9883.937757317202 10461.090858771784 0.9958605954813332 0.8866170411498984 0.9647112922790742 0.8948084331799422 0.8893534117658584 0.8699121255287735 0.8298159616493309 0.8915503019152148 0.9448285929979635 1.0 13.35274567993761 -1.5228806842860745 0.9720695729788408 0.8974610320459112 73.9696110995304 0.18683849155474075 0.04839666260895229 2139.150822326427 3.329006297629716 0.015392451059546067 347862.40919637127 0.029999866058527853 1.5228806842860745 73.07215006748449 SQANGAGALSYVS(ph)PNTSK ddPTM_A459_Selumetinib_30min_R2 3 SQANGAGALSYVSPNTSK 18 0 O95453;O95453-3;O95453-2;A0A494C0W0;A0A494C0K5;A0A494C0Q6;A0A494C002;A0A494C1N1;A0A494C0Q2;F5H1Z4;A0A494C1K5;A0A494C0P9;A0A494BZU6;A0A494C1G3;A0A494C156;A0A494BZW7 O95453 PARN Poly(A)-specific ribonuclease PARN 1 SQANGAGALS(0.005)YVS(0.728)PNT(0.23)S(0.036)K;SQANGAGALSYVS(0.663)PNT(0.332)S(0.005)K;SQANGAGALS(0.001)YVS(0.994)PNT(0.005)SK 230.62 7.1767e-19 115068000.0 143856.0 133142.0 142197.0 162234.0 162952.0 127797.0 133861.0 137518.0 112578.0 139021.0 True False 135861.05942119542 143353.56328099454 133048.19983238762 140137.44933074 142480.51295063668 145399.8767243393 140085.80174053935 137918.1546126697 135096.74569213702 135007.1025100636 1.0063252739689614 1.0618223827913704 0.9854903731636641 1.0380005697870154 1.0553556835279538 1.0769794627175338 1.0376180151714403 1.0215622144945233 1.0006639886376847 1.0 17.042675781612985 -8.052329446110388 2.6912605789843447 1.0001569734715308 1.038447065624901 0.2605471400264312 0.024821456093052228 0.41206684955681067 5.553112464360599 0.020749885169186466 0.0069823810772362835 8.864832904564462e-09 8.052329446110388 0.0382900921533702 SQAPLESSLDSLGDVFLDS(ph)GRK ddPTM_A459_Selumetinib_30min_R1 1 SQAPLESSLDSLGDVFLDSGRK 22 1 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 SQAPLESSLDSLGDVFLDS(1)GRK 118.67 1.6983e-05 13283000.0 1654.1 2033.9 2221.0 2067.1 1721.7 1949.0 1951.5 1749.8 1170.6 1545.1 True False 1692.6373116816796 1795.7700424655422 1919.4003990797244 1706.1197892726964 1565.9725389908233 1929.3948295504106 1804.2967838383368 1703.3896198485656 1986.4227027587276 1743.4286355484999 0.970866990003958 1.0300221103690748 1.1009343083755545 0.9786003020054412 0.8982143043085632 1.1066669379004457 1.034912899242754 0.9770343248449985 1.1393771229034444 1.0 10.767711595580582 SQASDDSS(ph)LGK ddPTM_A459_Selumetinib_30min_R2 1 SQASDDSSLGK 11 0 O75140;H0Y770;A0A2R8Y6V4;A0A5F9UWT1;A0A2R8Y5T1;A0A2R8Y5K9;A0A2R8Y721;A0A2R8Y6H3;O75140-6;A0A2R8Y842;A0A2R8Y7U0;O75140-8;O75140-5;O75140-1;O75140-4;O75140-9;A0A2R8YEW8;A0A2R8Y5P2;A0A2R8Y7U6;A0A2R8YF97;A0A2R8Y6H8;A0A2R8YF50;O75140-2;A0A2R8Y5E9 O75140 DEPDC5 DEP domain-containing protein 5 1 SQASDDS(0.038)S(0.962)LGK 96.756 0.0196 0.0 11344.0 8070.8 9388.1 10332.0 8265.1 7999.8 9107.7 10363.0 7593.0 11619.0 True False 10713.54589363002 8689.804408287764 8784.079866990423 8924.763776305861 7226.764247068509 9101.699835045962 9531.226096565175 10393.15461431299 9111.812166146092 11283.529280212524 0.9494853629190239 0.7701317728245477 0.7784869121042398 0.79095498887541 0.640470199314482 0.8066359034497522 0.8447025624579808 0.9210907647963525 0.8075321062998537 1.0 13.461930766318636 -8.592660873632843 0.6838240733165893 0.9937057879241654 0.7862386302849423 0.3472597949072066 0.07933132447178319 0.9494104452901174 0.9977940368167024 0.08206021045113235 0.03234118485358763 2.5546954021424665e-09 8.592660873632843 -0.20746715763922308 SQASPS(ph)EDEETFELR ddPTM_A459_Selumetinib_30min_R2 1 SQASPSEDEETFELR 15 0 Q13829-2;Q13829 Q13829-2 TNFAIP1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 1 SQAS(0.004)PS(0.996)EDEETFELR 89.50200000000002 0.01653 11479000.0 44121.0 38025.0 45599.0 46008.0 51871.0 40575.0 30420.0 41483.0 30638.0 43405.0 True False 41668.931450357006 40941.39523035413 42665.209984437344 39741.63103177317 45354.50124737637 46163.83794682241 31834.59027608646 41603.708662119665 36766.456097245326 42151.784870266354 0.9885448879235965 0.9712849730174528 1.0121803884640044 0.9428220217504172 1.075980563740474 1.095181095863538 0.7552370646715464 0.9869975563351933 0.8722396029113393 1.0 15.363306101320909 -7.2381503452522535 24.993656095325253 0.9025349692011785 1.0118295257773484 0.3390765140142986 0.07566961034276422 920.1790438046819 987532.3117770039 0.028260570038697103 0.021875844444026814 5.778959551702227e-08 7.2381503452522535 0.10929455657616993 SQATS(ph)PGQTNGDSSLEVLATR ddPTM_A459_Selumetinib_30min_R1 1 SQATSPGQTNGDSSLEVLATR 21 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;C9J0X3;C9K0F0;A0A087WVI1;C9J760;Q96JY6-2 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 SQAT(0.107)S(0.893)PGQTNGDSSLEVLATR 211.87 5.9087e-18 5178500.0 551.66 480.94 623.0 465.7 456.25 387.47 560.06 303.64 323.79 359.34 True False 564.5126046564993 424.63132121705974 538.4000218940424 384.3742372716826 414.9822680574797 383.57240359461167 517.8142232931068 295.58648083827757 549.4479813140684 405.464789268007 1.3922604862326622 1.0472705212791829 1.3278588823113984 0.9479842576851135 1.0234730093497262 0.9460066909560308 1.2770880160221219 0.7290065343821969 1.3551065243075655 1.0 8.663432825415686 -1.522878745332132 0.7422810703588598 1.0447967654949746 53.952581766993525 0.20085382156502007 0.18680318616317382 560.3187192207102 2.4999404057399137 0.06508144826194466 49519.16962183608 0.02999999999642217 1.522878745332132 52.90778500149855 SQATS(ph)PGQTNGDSSLEVLATR ddPTM_A459_Selumetinib_30min_R2 2 SQATSPGQTNGDSSLEVLATR 21 0 Q96JY6;Q96JY6-3;Q96JY6-5;C9JSR2;C9JS55;Q96JY6-4;C9J0X3;C9K0F0;A0A087WVI1;C9J760;Q96JY6-2 Q96JY6 PDLIM2 PDZ and LIM domain protein 2 1 SQAT(0.001)S(0.997)PGQT(0.002)NGDSSLEVLATR;SQAT(0.007)S(0.992)PGQT(0.001)NGDSSLEVLATR 233.54 2.815e-25 7317800.0 50256.0 47475.0 47270.0 64010.0 69580.0 51869.0 45064.0 45070.0 50067.0 61774.0 True False 47462.972710707894 51116.17984381497 44228.699663684565 55291.727576591 60838.73834690776 59013.48393009813 47159.565292621955 45201.14623825985 60081.798988862916 59990.42411187267 0.7911758153634144 0.8520723198837762 0.7372626601406421 0.9216758906968329 1.0141408274336103 0.9837150645917638 0.7861182178788536 0.7534726901407939 1.0015231577096346 1.0 15.872444610456244 -5.7793864165840745 24.781156908358177 0.9133077085168485 0.7993604710715816 0.30378145654131006 0.08883588075161564 315.5479649251731 435705.6742774471 0.027003979858107676 0.040148125745110334 1.6619332754502787e-06 5.7793864165840745 -0.11394723744526691 SQCT(ph)SPQPGTITPSASGCVR ddPTM_A459_Selumetinib_30min_R2 1 SQCTSPQPGTITPSASGCVR 20 0 Q9P2F5-2;Q9P2F5 Q9P2F5-2 STOX2 Storkhead-box protein 2 1 S(0.006)QCT(0.657)S(0.295)PQPGT(0.042)ITPSASGCVR 164.58 3.1319e-07 6627300.0 14122.0 14125.0 14359.0 15573.0 19908.0 11417.0 12630.0 13234.0 11737.0 16682.0 True False 13337.155774845129 15208.342080966531 13435.157572897117 13451.930535076584 17406.979060221885 12989.5881167929 13217.320025870218 13272.508748993365 14084.727959180378 16200.347314958713 0.8232635705612413 0.9387664218114505 0.8293129345746595 0.8303482804134479 1.0744818442348467 0.8018092368179579 0.8158664606940806 0.8192730989623965 0.8694090123719223 1.0 13.983737122548076 -4.430825128112184 12.740417880564587 0.8785595740468585 0.0001356838649086609 0.03885458492542482 0.08656061658403624 503035.36024025216 1650143.1064185146 0.02136336769365679 11859048.545907771 3.7083000917282496e-05 4.430825128112184 -0.8784238901819498 SQDADS(ph)PGSSGAPENLTFK ddPTM_A459_Selumetinib_30min_R2 2 SQDADSPGSSGAPENLTFK 19 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;H0Y8L4;H0Y948;H0Y8U8 A8MQ02 MLLT4 Afadin 1 SQDADS(0.999)PGSSGAPENLTFK;S(0.12)QDADS(0.524)PGS(0.01)S(0.343)GAPENLT(0.003)FK 133.92 0.00021701 13560200.0 42226.0 39440.2 47263.0 42423.0 52665.0 32674.7 36922.2 43724.3 31529.5 41835.0 True False 39879.24796407096 42465.13651976891 44222.15003606354 36644.91421624307 46048.75186892631 37175.34333360541 38639.15545995133 43851.530474052466 37836.28100783658 40627.114849616206 0.9815919272556389 1.0452412551803458 1.0884885672968554 0.9019817024144221 1.1334487334229524 0.9150377394804493 0.9510681623092502 1.0793660991279257 0.931306127641353 1.0 15.310155294205963 SQDAT(ph)FSPGSEQAEK ddPTM_A459_Selumetinib_30min_R1 1 SQDATFSPGSEQAEK 15 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SQDAT(0.494)FS(0.494)PGS(0.012)EQAEK 231.41 1.3264e-13 56620000.0 6051.8 7418.8 7045.9 7806.0 6452.2 6251.0 6935.6 5984.4 3361.1 5476.5 True False 6192.79516524708 6550.203447093449 6089.105480358323 6442.828636767782 5868.599649228429 6188.120615453884 6412.442108116409 5825.674271929221 5703.541214968701 6179.46212062738 1.002157638376841 1.0599957276586442 0.9853779117817647 1.0426196505455176 0.9496942508375811 1.0014011728945795 1.0377023085409538 0.9427477923171993 0.922983441540967 1.0 12.59326555164691 -6.729980191810287 0.5930322442488704 0.9622074488726314 1.027600793300891 0.22244888008359043 0.03791876800640791 1.2898769825170022 0.9899548912598319 0.03148407705054551 0.03715460612372823 1.862172068472891e-07 6.729980191810287 0.06539334442825961 SQDAT(ph)FSPGSEQAEK ddPTM_A459_Selumetinib_30min_R2 1 SQDATFSPGSEQAEK 15 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SQDAT(0.493)FS(0.493)PGS(0.013)EQAEK 167.18 0.0001744 55334000.0 72342.0 63723.0 71490.0 74266.0 70713.0 58691.0 64273.0 75644.0 58514.0 67083.0 True False 68321.52124797106 68610.34919826052 66890.41123242666 64150.84268400426 61829.400757759126 66775.15250614805 67261.8218545334 75864.1115164617 70218.43501776284 65146.13948743409 1.0487424394679514 1.053175978470599 1.0267747522526491 0.9847220908059823 0.9490877163900906 1.0250055188462577 1.0324759438355882 1.1645219826279187 1.0778602626377751 1.0 15.991392067823222 -7.543439229306362 24.75185706042964 1.0924145174454527 1.0139069705032642 0.2752776448316602 0.04695675806184553 240.37792581290233 289376.55682467774 0.022431943451952683 0.012952906596298532 2.8612827110281904e-08 7.543439229306362 -0.07850754694218853 SQDATFS(ph)PGS(ph)EQAEKSPGPIVSR ddPTM_A459_Selumetinib_30min_R1 1 SQDATFSPGSEQAEKSPGPIVSR 23 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 2 S(0.001)QDAT(0.031)FS(0.966)PGS(0.969)EQAEKS(0.033)PGPIVSR 80.41 0.0011192 26955000.0 2594.6 3147.8 3697.4 4004.8 2863.2 3009.2 2942.7 2889.2 1831.8 2773.0 True False 2655.0491317872493 2779.254112627481 3195.313388364416 3305.436859406561 2604.224065539017 2978.9301801349916 2720.7297698186376 2812.5690305557623 3108.430810621424 3128.941561307352 0.8485454521170097 0.8882409780341942 1.0212122296810593 1.0564073488242025 0.8323019188798481 0.9520568287284721 0.8695367799332906 0.8988883222800105 0.9934448278166761 1.0 11.611458998530347 -8.278517857219429 21.016448646723923 0.9967227193633016 0.9240441971849951 0.16317110715743266 0.06838879876899938 240.6014359995893 296056.5225203664 0.06815071127538916 0.017925311312589374 5.266015617682815e-09 8.278517857219429 -0.0726785221783065 SQDATFS(ph)PGSEQAEK ddPTM_A459_Selumetinib_30min_R2 1 SQDATFSPGSEQAEK 15 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SQDAT(0.002)FS(0.949)PGS(0.049)EQAEK 274.45 2.1986999999999997e-45 57658000.0 72131.0 71032.0 74491.0 83418.0 76184.0 63475.0 73464.0 75549.0 54187.0 67956.0 True False 68122.24778327101 76479.92599612138 69698.33015966846 72056.32449592376 66613.08482639855 72218.10508131991 76880.22156615437 75768.83508218969 65025.9141112812 65993.93370910782 1.0322501471657155 1.1588932754521708 1.0561323782711471 1.0918628492966964 1.0093819398616222 1.0943142956085536 1.1649589173609776 1.148118180318941 0.9853316881807119 1.0 16.010045794777874 -8.27847757806575 24.745138903336464 0.9926658055178215 1.0947759866920501 0.40182943818541805 0.049692347868218176 856.3491817557086 1243690.773348837 0.048899920288270844 0.012761658971134628 5.266504043158398e-09 8.27847757806575 0.10211018117422865 SQDATFS(ph)PGSEQAEKS(ph)PGPIVSR ddPTM_A459_Selumetinib_30min_R1 1 SQDATFSPGSEQAEKSPGPIVSR 23 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 2 S(0.006)QDAT(0.113)FS(0.845)PGS(0.192)EQAEKS(0.842)PGPIVS(0.001)R 76.749 0.0016199 23730000.0 7088.2 7779.2 9355.7 9411.2 7887.4 7482.2 6022.0 7272.3 4282.4 6214.4 True False 7253.341268763729 6868.407647548035 8085.247327181523 7767.710590103626 7173.98606263357 7406.9358612940405 5567.755691659982 7079.414980240437 7266.920025879015 7012.078773382045 1.0344067006630786 0.9795109081804118 1.153045707055266 1.1077614557882565 1.0230897704495459 1.0563109886059578 0.7940235515886195 1.0096028879644081 1.0363431816345747 1.0 12.775626488022699 -7.054554196434348 24.99963533850913 0.955703266107585 1.0606586041767394 0.29180005301073064 0.07546527654484038 402.09060030565973 184258.04396155113 0.029591096233899168 0.022921263823837978 8.819537345851869e-08 7.054554196434348 0.10495533806915436 SQDATFSPGS(ph)EQAEK ddPTM_A459_Selumetinib_30min_R1 3 SQDATFSPGSEQAEK 15 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SQDAT(0.281)FS(0.03)PGS(0.689)EQAEK;SQDAT(0.102)FS(0.037)PGS(0.861)EQAEK;SQDAT(0.007)FS(0.025)PGS(0.967)EQAEK 268.18 8.383600000000001e-45 73154800.0 13948.599999999999 14939.0 15078.7 16574.9 14823.900000000001 12839.0 14113.5 14116.1 7932.700000000001 13416.6 True False 14273.575240749095 13189.934935047317 13031.095361370306 13680.404864407152 13483.08086237212 12709.851316879282 13048.907332155963 13741.695172445043 13461.212518515436 15138.7512987509 0.9428502363947817 0.8712696757318168 0.8607774250473025 0.9036679838670659 0.8906336193979626 0.839557442094182 0.8619540062879975 0.9077165547715201 0.8891890918127523 1.0 13.885958590857596 -9.226709363284401 1.183084626160583 1.0001650157020727 0.8816266689002465 0.6084389294039729 0.02761353139772153 2.893542145837663 4.263356275618369 0.027867725291629335 0.008180252020262135 5.933222523572883e-10 9.226709363284401 -0.11853834680182618 SQDATFSPGS(ph)EQAEK ddPTM_A459_Selumetinib_30min_R2 2 SQDATFSPGSEQAEK 15 0 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SQDATFS(0.166)PGS(0.834)EQAEK;SQDAT(0.003)FS(0.058)PGS(0.939)EQAEK 142.57 0.00038089 61092000.0 110032.0 98926.0 123352.0 109521.0 118765.0 101626.0 98784.0 106378.0 94010.0 101802.0 True False 103916.86193299532 106513.30610277475 115415.6666155027 94604.05086573685 103844.67892742864 115624.05903102354 103377.65173678256 106687.54236817414 112814.6268588692 98862.71174663882 1.0511229167910048 1.0773860459719389 1.1674337530947472 0.9569234870694637 1.0503927830096083 1.1695416501151616 1.0456687856359275 1.079148452265688 1.1411241393821543 1.0 16.5931388588551 SQDATFSPGS(ph)EQAEKS(ph)PGPIVSR ddPTM_A459_Selumetinib_30min_R2 1 SQDATFSPGSEQAEKSPGPIVSR 23 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 2 S(0.002)QDAT(0.019)FS(0.106)PGS(0.876)EQAEKS(0.959)PGPIVS(0.039)R 53.603 0.046689 18424000.0 124620.0 130700.0 130110.0 149250.0 147860.0 93360.0 107060.0 106260.0 84522.0 149260.0 True False 117694.11929338622 140724.26973326164 121738.86425305698 128921.89252938952 129284.5049148287 106219.49256230037 112038.50213536555 106569.19900771009 101428.7617419991 144950.47597594614 0.8119609025148493 0.9708437918935442 0.839865225922121 0.8894202772454746 0.8919219067364972 0.7327985082293003 0.7729433199926699 0.735211100827256 0.6997476969915624 1.0 17.14520054524219 -6.752026799854616 24.95331395850287 0.7706410177981027 0.884009221776608 0.20934330602918094 0.0866578531625883 240.02115344023335 636309.6683194658 0.026824051291347295 0.02648297618610885 1.7699997301299824e-07 6.752026799854616 0.11336820397850533 SQDATFSPGSEQAEKS(ph)PGPIVSR ddPTM_A459_Selumetinib_30min_R1 3 SQDATFSPGSEQAEKSPGPIVSR 23 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 SQDATFSPGSEQAEKS(0.972)PGPIVS(0.028)R;SQDATFSPGS(0.001)EQAEKS(0.897)PGPIVS(0.102)R;SQDATFSPGSEQAEKS(0.999)PGPIVS(0.001)R 116.35 5.9441e-06 210050000.0 3587.43 4479.09 5661.3 5387.1 4689.71 4349.4 4347.4 4329.8 2392.77 3564.6400000000003 True False 3671.0101390763634 3954.6760605275517 4892.526555294931 4446.344113391198 4265.526558535546 4305.648984939228 4019.4721178881805 4214.959638827474 4060.3559289936834 4022.19626653395 0.9126879684167639 0.9832131001243799 1.216381854859353 1.1054518026348699 1.0604968718275107 1.0704721250834281 0.9993227211042794 1.0479249045844383 1.0094872701208628 1.0 11.973767765571083 -7.251150731872122 23.60871407170087 1.018177467170458 1.0641661292498574 0.07197812239921653 0.07488173461249223 1030.1354396477593 2363792.0275884545 0.031261417729816804 0.02391578649442164 5.608532852376339e-08 7.251150731872122 0.045988662079399445 SQDLHCGACR ddPTM_A459_Selumetinib_30min_R1 1 SQDLHCGACR 10 0 F8W031;F8VXJ7;F8W1U5;F8VP03;Q9Y2B0-2;Q9Y2B0 F8W031;Q9Y2B0 CNPY2 Protein canopy homolog 2 0 106.16 0.016961 1371600.0 2026.3 2121.6 2270.2 2617.5 2677.2 1942.8 2197.7 2014.8 991.24 1707.9 False True 2073.508847506554 1873.2020856949196 1961.9193093159781 2160.402761560295 2435.0477326980513 1923.2571959212614 2031.9257196215783 1961.3609590072517 1682.0618826948253 1927.1256013547872 1.0759593697727112 0.9720186812826528 1.018054717314082 1.121049276726702 1.2635646223506085 0.9979926552629438 1.0543815712858133 1.0177649851303914 0.8728345892516399 1.0 10.912234887715808 -7.974147189535371 3.0055009764188823 0.9361868241565527 1.0727768385822345 0.29999310784127586 0.08152746000814101 0.34489966208683953 6.162171697782806 0.06274811119188915 0.023630765224739367 1.0613357920993383e-08 7.974147189535371 0.13659001442568175 SQDLHCGACR ddPTM_A459_Selumetinib_30min_R2 1 SQDLHCGACR 10 0 F8W031;F8VXJ7;F8W1U5;F8VP03;Q9Y2B0-2;Q9Y2B0 F8W031;Q9Y2B0 CNPY2 Protein canopy homolog 2 0 101.3 0.023197 1726100.0 22139.0 16689.0 21691.0 29144.0 31819.0 22548.0 18597.0 22077.0 20766.0 25257.0 False True 20908.60300943892 17968.992636407103 20295.42467537512 25174.536923795793 27821.61275453084 25653.782329635313 19461.79734925641 22141.24041495591 24919.78025051886 24527.764784433053 0.8524463273844222 0.7325980493669533 0.8274469709631244 1.0263689800129372 1.1342905886062753 1.0459078744067583 0.7934598819052666 0.9027011066661979 1.015982518975174 1.0 14.582128146614783 -5.669478652515752 5.326804713736811 0.9843702464411241 0.7906648372085181 0.47236368044072896 0.08941911036146295 0.19990644090452106 9.050195119293935 0.02753071557896608 0.04824774598763106 2.1405301406583544e-06 5.669478652515752 -0.19370540923260604 SQDQDS(ph)EVNELSR ddPTM_A459_Selumetinib_30min_R1 2 SQDQDSEVNELSR 13 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 SQDQDS(1)EVNELSR;SQDQDS(0.974)EVNELS(0.026)R 147.75 0.00056482 19619300.0 5919.5 6597.700000000001 6273.7 5883.799999999999 5743.700000000001 5759.6 6407.6 5326.6 3366.15 4642.5 True False 6057.412832658069 5825.238216812488 5421.7659989673375 4856.304782604951 5224.1833491326 5701.663653298384 5924.269573211646 5185.3212647647515 5712.1106961312935 5238.41009677944 1.1563456699165553 1.1120240892162734 1.0350022046385075 0.9270570063979132 0.9972841477883553 1.0884339996220898 1.1309289390790291 0.9898654685231063 1.090428315194926 1.0 12.354913292313652 -5.125373084453082 3.256167523253424 1.0325057930375643 1.1490729171355538 0.3560083480171331 0.056161538598915595 0.30238234033350814 5.817326254822974 0.01592694005454314 0.05611229819314347 7.49250282812719e-06 5.125373084453082 0.11656712409798953 SQDQDS(ph)EVNELSR ddPTM_A459_Selumetinib_30min_R2 2 SQDQDSEVNELSR 13 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 SQDQDS(1)EVNELSR;SQDQDS(1)EVNELSR 231.41 3.472300000000001e-13 70517000.0 135804.0 111665.0 154460.0 146239.0 170806.0 121445.0 114696.0 136574.0 108616.0 129224.0 True False 128256.5573464856 120229.34644043364 144522.21176333242 126320.99592365373 149347.82325498585 138172.9463820544 120029.59126581228 136971.40772895716 130342.23498460751 125492.96735572598 1.022021871416315 0.9580564470965777 1.1516359427031924 1.0065982069384063 1.190089185090669 1.1010413515076536 0.9564646832007163 1.0914668018064635 1.038641748068126 1.0 16.937246992036734 -5.235796780044461 24.873296567361017 1.0697669399381364 0.9900391565776268 0.16586662417205544 0.06880308020805491 1231.1659961176406 1194225.244745393 0.017174281221533836 0.04539447094725531 5.810362389273846e-06 5.235796780044461 -0.07972778336050967 SQDSVS(ph)SPSPQK ddPTM_A459_Selumetinib_30min_R2 1 SQDSVSSPSPQK 12 0 Q70CQ4;I3L4X5 Q70CQ4 USP31 Ubiquitin carboxyl-terminal hydrolase 31 1 SQDS(0.095)VS(0.439)S(0.439)PS(0.028)PQK 94.688 0.020799 0.0 20906.0 14647.0 19529.0 18395.0 19919.0 12294.0 13705.0 11679.0 8455.1 14516.0 True False 19744.128213348842 15770.37780247199 18272.5254015675 15889.569266855047 17416.59714188064 13987.386906179536 14342.30965594231 11712.983956437462 10146.356255232693 14096.88536290258 1.4006021688526722 1.11871363045722 1.2962101152963583 1.1271687935173327 1.2354925711259757 0.9922324361797535 1.0174098239945677 0.830891622858862 0.7197587264158284 1.0 13.783088821048468 -7.068372365885396 1.0858903094657317 0.8352611933266794 1.2448464259359844 0.7080843133567576 0.10627495928140696 0.2638203841535353 0.6311454807917685 0.06410740237816263 0.04317021882592279 8.543338893556283e-08 7.068372365885396 0.409585232609305 SQDSVSS(ph)PSPQK ddPTM_A459_Selumetinib_30min_R2 1 SQDSVSSPSPQK 12 0 Q70CQ4;I3L4X5 Q70CQ4 USP31 Ubiquitin carboxyl-terminal hydrolase 31 1 SQDS(0.004)VS(0.488)S(0.501)PS(0.007)PQK 113.37 0.0059856 2206100.0 24792.0 19798.0 21306.0 20906.0 21751.0 16282.0 16501.0 16784.0 10944.0 18208.0 True False 23414.159890239374 21316.442939396497 19935.195156218833 18058.56673513845 19018.444923592833 18524.697706719962 17268.3291961112 16832.838661259226 13133.105800909098 17682.287729934556 1.3241589690117566 1.2055251710054258 1.1274104041679123 1.0212799956063878 1.07556472409372 1.0476414584838636 0.9765890850694302 0.951960454345662 0.7427266200784588 1.0 14.110017321875715 -3.735018260541326 0.32556726419678794 0.894987848635158 2.053201254756254 0.7522691762763203 0.0736014431495821 7.003459704305859 0.35186994953194906 0.07353921994410964 3.645823987267979 0.00018406946051677107 3.735018260541326 1.1582134061210958 SQDSYPGS(ph)PS(ph)LSPR ddPTM_A459_Selumetinib_30min_R1 1 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 2 SQDS(0.007)Y(0.001)PGS(0.973)PS(0.675)LS(0.344)PR 122.16 0.033033 4104300.0 1577.6 1469.4 2002.3 1874.4 1776.1 1380.0 1388.4 1563.7 889.2 1216.9 True False 1614.3550105247675 1297.3619648944723 1730.3986578466152 1547.0712268456998 1615.4520685959233 1366.1184529397478 1283.671870192747 1522.2255963865596 1508.9074554015567 1373.1009686097798 1.1757001469158161 0.9448409072262247 1.260212247609575 1.1266988096382011 1.1764991107911869 0.9949147835230926 0.9348707047322407 1.1086042695955298 1.098904953019789 1.0 10.423222000137487 -6.764971108728426 24.99917224558241 1.028459938822761 1.132422537264741 0.2777524988889378 0.08800304334786319 137.4181053102009 972700.6887528423 0.030910987287384985 0.0283330935178615 1.7180226741466017e-07 6.764971108728426 0.10396259844197986 SQDSYPGS(ph)PSLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 2 S(0.001)QDS(0.012)YPGS(0.987)PS(0.399)LS(0.601)PR 132.25 0.014977 5658500.0 37391.0 33183.0 42404.0 40298.0 43636.0 28033.0 27770.0 32491.0 34170.0 36935.0 True False 35312.95790803245 35728.02939983804 39675.77280598436 34809.342882072575 38154.05556921046 31894.29129176275 29061.36002521107 32585.543430825386 41004.95478957092 35868.5905813452 0.9845092136516307 0.9960812181569167 1.1061425097260227 0.9704686556648946 1.063717724918188 0.8891983424726638 0.8102175065759488 0.908470137875245 1.143199499199087 1.0 15.130433436769819 -6.75867507783887 24.99972063046351 0.9357465060553101 1.0241916865319654 0.1372998553828193 0.08908582387499075 132.47039379590305 1198032.979847509 0.03103545651707915 0.029719663441478566 1.7431105128377266e-07 6.75867507783887 0.08844518047665528 SQDSYPGS(ph)PSLSPR ddPTM_A459_Selumetinib_30min_R1 1 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 1 SQDSYPGS(0.758)PS(0.234)LS(0.007)PR 152.59 0.00037958 10108000.0 3006.7 3940.2 3963.1 3679.1 4374.2 3467.2 3492.6 3575.4 1792.6 3056.3 True False 3076.750259980238 3478.8795522507166 3424.9327877500455 3036.6142502603575 3978.554382327732 3432.323115965717 3229.150370091609 3480.5687774640314 3041.911273676147 3448.6058758830377 0.8921721909414819 1.0087785260065205 0.9931354614052756 0.8805338619574244 1.1536703599998934 0.9952784514950839 0.9363639935412348 1.0092683544398384 0.8820698517476272 1.0 11.75179754439762 -4.752531449277257 24.430832638573612 0.9857983457999263 0.8921719487239343 0.1239847985539434 0.07340933651991119 563.065033341088 1544103.474123247 0.017933459185444457 0.20670717890013007 1.767944188062156e-05 4.752531449277257 -0.09362639707599196 SQDSYPGS(ph)PSLSPR ddPTM_A459_Selumetinib_30min_R2 1 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 1 S(0.033)QDSYPGS(0.721)PS(0.243)LS(0.002)PR 91.14 0.017356 10301000.0 33548.0 25081.0 29359.0 35584.0 37309.0 21977.0 25684.0 24246.0 24356.0 23723.0 True False 31683.53646328454 27004.632051874076 27470.073903662265 30737.397814176125 32621.909873308105 25004.13226265723 26878.356891880492 24316.551845858634 29227.880563499835 23038.055350243703 1.3752695694842743 1.172174979238793 1.1923781537130338 1.3342010576361854 1.4160010199369115 1.0853404023266542 1.1666938239036815 1.0554949832430802 1.2686782855216403 1.0 14.49173132311073 -6.783342996132255 24.999962438993137 1.1219256652894816 1.2871571769079324 0.4708336387780382 0.09640518098660847 242.37516342164676 276635.9132911505 0.03411842435876696 0.030113945042655958 1.6468612233735426e-07 6.783342996132255 0.16523151161845084 SQDSYPGSPS(ph)LSPR ddPTM_A459_Selumetinib_30min_R2 2 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 1 SQDS(0.002)YPGS(0.004)PS(0.871)LS(0.122)PR;SQDSYPGS(0.156)PS(0.844)LSPR 195.5 0.00012508 23793000.0 69266.0 63152.0 76653.0 81474.0 77233.0 56757.0 56185.0 65344.0 58834.0 60417.0 True False 65416.473013767325 67995.55533431486 71721.22943347594 70377.10064951063 67530.3000682197 64574.76156125199 58797.7138284654 65534.140221718466 70602.44395930975 58672.60422778207 1.1149406758868898 1.158897857513512 1.2223972393493183 1.1994882718395916 1.1509681725742016 1.1005947735088806 1.002132334201455 1.1169461639592162 1.2033289622736532 1.0 15.84039940808718 -6.707345408428486 3.4559535649013533 1.0857642003822996 1.1759318783904995 0.33836278643603324 0.060015119232122466 0.2979423232881263 7.244032995072117 0.02198095663069445 0.021173146527704995 1.9617993737950137e-07 6.707345408428486 0.09016767800819991 SQDSYPGSPSLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SQDSYPGSPSLSPR 14 0 A0A0D9SEU5;R4GMX8;Q6VN20-2;Q6VN20-3;Q6VN20 A0A0D9SEU5 RANBP10 Ran-binding protein 10 1 SQDSYPGS(0.004)PSLS(0.996)PR 220.72 7.336e-09 10847000.0 43905.0 45007.0 52312.0 51299.0 50771.0 31926.0 37829.0 43726.0 33801.0 39680.0 True False 41464.93586564051 48458.892179685725 48946.3028729991 44311.98770428904 44392.69308150114 36323.51670462729 39588.12345674142 43853.235420771045 40562.144478849455 38534.33529897867 1.0760516703849698 1.2575510075288647 1.2701997450646667 1.1499351775626319 1.1520295533079492 0.9426273068628751 1.0273467324552676 1.1380301510464448 1.0526234373614465 1.0 15.233856884843371 -6.5803189985342945 7.002448497333954 1.0403802899587018 1.193484290636951 0.5454414897469357 0.06837796445949999 0.1782820275061826 17.514172407575995 0.02370368550118077 0.023742786079610015 2.628336713479551e-07 6.5803189985342945 0.15310400067824914 SQDSYPVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SQDSYPVSPR 10 0 Q96S59-2;Q96S59-3;Q96S59 Q96S59-2 RANBP9 Ran-binding protein 9 1 SQDSYPVS(1)PR;SQDSYPVS(1)PR 105.66 0.012376 11101600.0 87032.0 58302.0 75575.0 86325.0 96522.0 71491.0 87381.0 96145.0 98109.0 72532.0 True False 82195.10985670028 62773.57592952284 70712.58677983837 74567.3860810689 84396.0434423718 81338.23631931686 91444.38964216666 96424.76603233845 117733.5413944982 70437.81269923192 1.1669174085185154 0.8911914428343308 1.0039009456721737 1.0586272234129441 1.1981638868137665 1.1547524433592158 1.2982286947584873 1.3689347005147692 1.6714536820900179 1.0 16.10406248949986 -6.870117039334119 1.0796385676829532 1.378551710347431 1.0147102821499587 0.37561856776362257 0.1683426897959916 0.4692538883920594 1.151929304321804 0.09369154449294631 0.07613519816899676 1.3485993954832346e-07 6.870117039334119 -0.3638414281974722 SQDVAVS(ph)PQQQQCSK ddPTM_A459_Selumetinib_30min_R1 4 SQDVAVSPQQQQCSK 15 0 H3BQ37;H3BPW9;Q96F86;H3BTD6 H3BQ37 EDC3 Enhancer of mRNA-decapping protein 3 1 S(0.481)QDVAVS(0.519)PQQQQCSK;S(0.007)QDVAVS(0.993)PQQQQCSK;S(0.001)QDVAVS(0.999)PQQQQCSK;S(0.001)QDVAVS(0.999)PQQQQCSK 294.98 9.791999999999995e-68 204121000.0 18210.199999999997 21271.500000000004 23840.5 24091.000000000004 22043.8 19348.0 21000.8 19130.3 10903.2 16109.7 True False 18634.462229119 18781.02289114794 20603.09104649264 19883.95909407797 20049.942182148996 19153.376686578427 19416.69274815891 18622.902300028007 18501.93406177941 18177.536916766345 1.0251368111337023 1.0331995460740866 1.1334368974648619 1.0938753245351784 1.103006544503596 1.0536838282480396 1.0681696225988466 1.0245008652877976 1.0178460451764426 1.0 14.14986910500521 -7.8450923505938315 1.3835439107733003 1.0039279431181494 1.0776935394606209 0.44197000206388626 0.030659722230589548 0.4413230193280977 1.5375574122166447 0.028283977274723714 0.010378517219643361 1.4285901435149564e-08 7.8450923505938315 0.07376559634247148 SQDVAVS(ph)PQQQQCSK ddPTM_A459_Selumetinib_30min_R2 4 SQDVAVSPQQQQCSK 15 0 H3BQ37;H3BPW9;Q96F86;H3BTD6 H3BQ37 EDC3 Enhancer of mRNA-decapping protein 3 1 S(0.007)QDVAVS(0.993)PQQQQCSK;S(0.001)QDVAVS(0.999)PQQQQCSK;SQDVAVS(1)PQQQQCSK;SQDVAVS(1)PQQQQCSK 289.5 3.7316999999999994e-67 408407000.0 260708.0 235053.0 256403.0 282350.0 277290.0 208124.0 218546.0 215118.0 180998.0 235109.0 True False 246218.8930568137 253080.80928548172 239906.31013047838 243893.44291908303 242454.3511959477 236791.19183843402 228708.82204068342 215743.9577652978 217202.6575066653 228320.7922834574 1.0783901483275162 1.1084439868765217 1.050742281205111 1.068205135764825 1.0619021980921635 1.0370986780059028 1.0016994937401245 0.9449159474598107 0.9513047643817341 1.0 17.80070272058874 -7.2015671305175655 1.4439671147209463 0.9605670714062441 1.0761415681950737 0.8470970904538114 0.020161847955805456 0.14870317715398415 0.6094413369548809 0.011752364601268803 0.007299936898225687 6.286846684734753e-08 7.2015671305175655 0.11557449678882958 SQEDEIS(ph)SPVNK ddPTM_A459_Selumetinib_30min_R1 3 SQEDEISSPVNK 12 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SQEDEIS(0.5)S(0.5)PVNK;SQEDEIS(0.5)S(0.5)PVNK;SQEDEIS(0.5)S(0.5)PVNK 230.69 5.278899999999999e-10 157928000.0 10369.8 17504.3 16008.8 18242.4 12245.599999999999 15427.3 13667.900000000001 12142.8 6375.3 9910.1 True False 10611.396163881685 15454.88841847171 13834.892890043895 15056.707292258843 11137.987642136279 15272.115368867664 12636.919298910587 11820.733498626785 10818.41846651096 11182.157867548502 0.9489578209834426 1.3821025066479349 1.2372292587814235 1.3464938941664013 0.9960499372361387 1.3657574459030435 1.1300966636845575 1.0571066549624988 0.9674714482351263 1.0 13.448910997463427 -7.7349585427671155 2.5195057107106003 0.9934165028104321 1.2191864964948906 0.3055439437802998 0.13822645727039354 0.33654722215762234 4.2825292196013525 0.08316462563456938 0.03751730342181799 1.8409477277543153e-08 7.7349585427671155 0.2257699936844585 SQEDEIS(ph)SPVNK ddPTM_A459_Selumetinib_30min_R2 2 SQEDEISSPVNK 12 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SQEDEIS(0.5)S(0.5)PVNK;SQEDEIS(0.5)S(0.5)PVNK 182.72 0.00010424 93820300.0 346349.0 307434.0 437445.0 421128.0 423258.0 340476.0 332939.0 374957.0 319491.0 391933.0 True False 327100.3091248995 331013.19924388384 409300.2649541036 363769.63991368 370084.5460654709 387373.47846660035 348421.3232061123 376048.0627925275 383398.1273244011 380616.87592577044 0.859395181386261 0.8696755718956599 1.0753602660380386 0.955737023033692 0.9723282635992377 1.017751715617958 0.9154121775568957 0.9879962938528927 1.0073072203954854 1.0 18.537980004190267 -5.1540576307695 8.547850184065346 0.9872426095823911 0.8625584812500211 0.6210276998480568 0.039577095623140886 0.19837947646666132 14.338128905174122 0.009820836901875123 0.02620158229635864 7.013622216524788e-06 5.1540576307695 -0.12468412833236997 SQEDEISS(ph)PVNK ddPTM_A459_Selumetinib_30min_R2 1 SQEDEISSPVNK 12 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SQEDEIS(0.032)S(0.968)PVNK 141.34 0.00099971 104190000.0 300780.0 277590.0 353440.0 317600.0 381020.0 259450.0 270260.0 319560.0 246740.0 320390.0 True False 284063.8517177393 298880.2604074694 330700.05519637524 274342.3321094408 333152.86123798153 295186.8824473959 282827.62551003066 320489.86669399426 296094.8944916222 311139.5082268093 0.9129790470410692 0.9605988712613013 1.0628674483708027 0.8817341573653683 1.0707507482306788 0.9487283827427516 0.9090058254635398 1.0300519806066186 0.9516467265088684 1.0 18.247202073114764 -4.839187635511183 4.417358885309811 0.9805491137730744 0.9118748408432584 0.1101714674938502 0.05878939542398003 0.42944629181685623 14.14164570302302 0.01388833815849955 0.0751628977108855 1.4481460515990981e-05 4.839187635511183 -0.06867427292981598 SQEEPKDT(ph)FEHDPSESIDEFNK ddPTM_A459_Selumetinib_30min_R2 1 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.135)QEEPKDT(0.865)FEHDPSESIDEFNK 126.29 4.1548e-05 24499000.0 46161.0 38016.0 43589.0 44533.0 37528.0 35077.0 34654.0 42983.0 24029.0 40119.0 True False 43595.556417124084 40931.704959293726 40784.5311961148 38467.52857629005 32813.397135423285 39908.53835269725 36265.47966559828 43108.07341378128 28835.47142635643 38960.660228319684 1.1189634919337272 1.0505906398768194 1.0468131432349133 0.9873428312266848 0.8422187135209767 1.0243291083575778 0.930823026434179 1.1064513065527295 0.7401176278167004 1.0 15.24973050512299 -5.7348880505396345 2.5595593260620713 0.9475771726226743 1.0791316017310792 0.2757976120606739 0.09548114069357427 0.3795976894628048 5.062777449953024 0.02664179587402156 0.049509816671150515 1.8412465642441936e-06 5.7348880505396345 0.13155442910840498 SQEEPKDTFEHDPS(ph)ESIDEFNK ddPTM_A459_Selumetinib_30min_R1 1 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SQEEPKDTFEHDPS(0.559)ES(0.44)IDEFNK 89.039 0.00025729 13513000.0 2580.6 2631.1 3579.6 3250.0 2663.2 2982.3 2599.6 2710.2 2034.5 2196.0 True False 2640.722959026508 2323.0495888347946 3093.509981335334 2682.4485100557636 2422.31403022615 2952.300769711744 2403.510079050032 2638.316692029707 3452.3979059991752 2477.8779908514057 1.0657195264562433 0.9375157281398623 1.248451292903407 1.0825587538852415 0.9775759900889375 1.1914633329857074 0.9699872584219448 1.0647484265854326 1.3932880951950835 1.0 11.274889436496068 SQEEPKDTFEHDPS(ph)ESIDEFNK ddPTM_A459_Selumetinib_30min_R2 2 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SQEEPKDTFEHDPS(0.5)ES(0.5)IDEFNK;SQEEPKDTFEHDPS(0.57)ES(0.429)IDEFNK 100.39 7.4398e-05 9227000.0 88771.0 82061.0 79898.0 80235.0 66176.0 63644.0 71679.0 68752.0 49642.0 79755.0 True False 83837.46319846892 88354.814832297 74757.44966636485 69306.8545869047 57862.37925905385 72410.38329729064 75012.21552924387 68952.05693749366 59571.78711337075 77452.26592162397 1.0824404192810357 1.1407647507912242 0.9652067473663575 0.8948331435136857 0.7470714842301237 0.9349033554494668 0.9684960747972273 0.8902522878706751 0.7691419534924007 1.0 16.24101982626049 -5.458434655266273 2.9438783333137626 0.8820815483667609 1.1120375810457621 0.5775968638051566 0.07595879018123944 0.18254749611482873 3.076015258563716 0.02141500714378889 0.04967655099264802 3.4798886274434817e-06 5.458434655266273 0.22995603267900122 SQEEPKDTFEHDPSES(ph)IDEFNK ddPTM_A459_Selumetinib_30min_R1 2 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SQEEPKDTFEHDPS(0.171)ES(0.829)IDEFNK;SQEEPKDT(0.003)FEHDPS(0.113)ES(0.884)IDEFNK 64.707 0.0031427 38905000.0 5484.4 6887.7 7848.5 8048.7 5759.2 7043.200000000001 6615.9 6499.6 4397.1 5739.1 True False 5612.175849215291 6081.284881995138 6782.716808724546 6643.145637811023 5238.281376869343 6972.351802713933 6116.857336508348 6327.2094943237735 7461.557548522476 6475.76938856799 0.8666423265662849 0.9390829903132042 1.0473993747674872 1.0258465425804864 0.8089048671369847 1.076683152896486 0.9445761529597938 0.9770591129284998 1.1522271873508574 1.0 12.660835894778591 -8.114599874595783 7.434788638082904 1.0751983121404052 0.9624127575257997 0.23590361905692847 0.08337164986534425 0.3836742006383021 22.26004599132515 0.055531815147101246 0.02079084557936845 7.680688027729148e-09 8.114599874595783 -0.11278555461460549 SQEEPKDTFEHDPSES(ph)IDEFNK ddPTM_A459_Selumetinib_30min_R2 1 SQEEPKDTFEHDPSESIDEFNK 22 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SQEEPKDTFEHDPS(0.374)ES(0.626)IDEFNK 63.372 0.0038673 5442900.0 54424.0 54706.0 52208.0 50948.0 43577.0 46239.0 45625.0 42891.0 34112.0 50862.0 True False 51399.33195653384 58901.77429248529 48848.994119772484 44008.79450979781 38102.46767667714 52608.002534149644 47746.65290422236 43015.80570901268 40935.35316891552 49393.481904653534 1.040609610307536 1.192500953996036 0.9889765255680476 0.8909838467097737 0.7714067971605656 1.0650798547812694 0.9666589813690373 0.8708802062597658 0.8287602248396839 1.0 15.592033052042222 -5.482313774651447 4.527359005995156 0.9118008383781334 1.1149587390886826 0.46404444146809287 0.08648335140434439 0.17668181278127307 8.169465211900619 0.023744232511210543 0.049248975822366904 3.2937165752881327e-06 5.482313774651447 0.20315790071054918 SQEPIPDDQKVS(ph)DDDKEKGEGALPTGK ddPTM_A459_Selumetinib_30min_R1 1 SQEPIPDDQKVSDDDKEKGEGALPTGK 27 3 E5RJU9;Q86UE4;H0YBJ8 E5RJU9 MTDH Protein LYRIC 1 SQEPIPDDQKVS(0.988)DDDKEKGEGALPT(0.012)GK 51.81100000000001 0.015393 25417000.0 513.31 662.2 861.24 890.86 418.97 804.75 374.13 428.17 578.71 715.85 True False 525.2691242726092 584.6693161515717 744.2883384526887 735.2880245133159 381.0742374751611 796.6549456545375 345.90907288620906 416.81354070782953 982.0286026939216 807.7363204694802 0.6502977654481444 0.7238368528627568 0.9214496359654674 0.9103069973205424 0.47178049051164306 0.9862809501886681 0.42824504002142244 0.5160267405897573 1.2157786864445288 1.0 9.657740602510232 -8.268972064987917 24.937246192161105 1.107889380890177 0.7088857780738419 0.422188375320912 0.19021333109457172 609.35031001907 2017249.823030872 0.1723809585306731 0.04797105664236572 5.383044066183947e-09 8.268972064987917 -0.3990036028163352 SQEPS(ph)PVGSR ddPTM_A459_Selumetinib_30min_R1 2 SQEPSPVGSR 10 0 Q96CP6-2;Q96CP6-3;Q96CP6;M0QZ12 Q96CP6-2 GRAMD1A GRAM domain-containing protein 1A 1 SQEPS(1)PVGSR;SQEPS(1)PVGSR 125.84 0.0035578000000000007 10317300.0 3685.3 5483.7 4927.0 5143.7 6145.200000000001 4909.0 4703.5 5021.1 2731.5 4823.2 True False 3771.1603196544943 4841.665854697033 4257.940462073749 4245.449354207333 5589.36774502318 4859.619917015377 4348.711208190424 4887.924117168608 4635.155999133321 5442.304701946493 0.6929344324116403 0.889635204174688 0.7823781826384795 0.780082995479637 1.0270221994413669 0.8929341856359654 0.7990569154709521 0.8981349602532167 0.8516899095112246 1.0 12.410002016641274 -3.2540381827031504 0.5244544031060401 0.8956435117665026 2.0732928866109191e-19 0.327593055785644 0.07992423421245114 26.159400300288034 1.5524224316270192 0.04351334503872366 20.38824501609467 0.0005571367639143124 3.2540381827031504 -0.8956435117665026 SQEPS(ph)PVGSR ddPTM_A459_Selumetinib_30min_R2 1 SQEPSPVGSR 10 0 Q96CP6-2;Q96CP6-3;Q96CP6;M0QZ12 Q96CP6-2 GRAMD1A GRAM domain-containing protein 1A 1 SQEPS(0.992)PVGS(0.008)R 125.84 0.0035578000000000007 17053000.0 116260.0 40586.0 88980.0 97699.0 60705.0 49347.0 106200.0 82433.0 66435.0 58205.0 True False 109798.7346256547 43698.81569544125 83255.12367409894 84392.22765982468 53078.695190414364 56144.1013225347 111138.51043130773 82672.86638248229 79723.85634899451 56524.470415248325 1.9424991303595627 0.7730955349853722 1.4729040902546806 1.4930211117388659 0.9390392302746031 0.9932707181523452 1.9662017107784604 1.4626031128666717 1.4104308410731752 1.0 15.786587949801369 -7.217873918775052 24.999621625050334 1.498361055448204 1.250888705372065 0.051827418725322705 0.3813655443432972 1185.6551631834009 680377.4231341623 0.14095090695004425 0.10917943215152484 6.055166384393743e-08 7.217873918775052 -0.2474723500761391 SQESGYYDR ddPTM_A459_Selumetinib_30min_R1 1 SQESGYYDR 9 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;D6R991 D6REM6 MATR3 Matrin-3 0 157.99 0.012003 10000000.0 2348.4 2865.0 2680.6 2840.6 2664.5 2492.0 2479.2 2321.1 1408.7 2018.3 False True 2403.113150809056 2529.564468097635 2316.589243481814 2344.54253466597 2423.496445455684 2466.932742554965 2292.1919479846274 2259.5368880046317 2390.461012622775 2277.368464906826 1.0552149060812497 1.110740096333567 1.017221973158653 1.029496355462133 1.0641652779515574 1.0832382991901552 1.0065090402832149 0.9921700958026906 1.0496593104974674 1.0 11.153152014646956 -7.276519370534153 24.462505012252002 1.0114321138810283 1.0591752012834201 0.4105561771676306 0.028118922002020118 664.2431577788283 1077518.059137677 0.012137432835201231 0.008225174808005645 5.290304007090305e-08 7.276519370534153 0.04774308740239186 SQETECTYFSTPLLLGK ddPTM_A459_Selumetinib_30min_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 127.3 0.010368 0.0 664.17 689.34 815.7 819.43 756.76 704.95 626.12 793.19 344.84 679.65 False True 679.6438687501493 608.6317523345282 704.9324203193747 676.3319331061515 688.3111916168298 697.8588430433877 578.8912643078962 772.1520245557685 585.1682938828977 766.8896978516195 0.8862341881161235 0.7936366260227014 0.9192096624771291 0.8819155284010746 0.8975361040121921 0.909985940609691 0.7548559668093261 1.006861908197347 0.7630410155752517 1.0 9.582875278838051 -11.164516421401228 2.9951716129330603 1.0109135619419731 0.8707009575420288 0.22250249788725418 0.0738058387540654 69126720.685117 79326372.96554907 5918478.77603065 0.016347645633922575 6.8467359394717385e-12 11.164516421401228 -0.14021260439994432 SQGAGS(ph)GQDEADVDPQRPPRPEVK ddPTM_A459_Selumetinib_30min_R2 1 SQGAGSGQDEADVDPQRPPRPEVK 24 2 Q9UHG0;Q9UHG0-2 Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 1 S(0.172)QGAGS(0.828)GQDEADVDPQRPPRPEVK 45.511 0.027314 5309700.0 16445.0 17056.0 17111.0 16977.0 19921.0 15133.0 19623.0 18717.0 13221.0 17684.0 True False 15531.052734550922 18364.140356316122 16010.09688904817 14664.703313041484 17418.3458840004 17217.433386303484 20535.508382236836 18771.463371233847 15865.569425604832 17173.416971450057 0.904365902276205 1.0693352631480144 0.9322604182769307 0.8539187825824538 1.0142620954791655 1.0025630551524256 1.1957730029135196 1.0930534908947045 0.9238446519979422 1.0 14.067889498523199 -6.709291810732338 2.7198400493939134 1.0617859730638441 0.9489990147489114 0.23133599244746061 0.08448830531753775 0.3863438576284412 5.835914130360311 0.03190216645629609 0.030520461878889436 1.953026738949131e-07 6.709291810732338 -0.1127869583149328 SQGDEAGGHGEDRPEPLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 SQGDEAGGHGEDRPEPLSPK 20 1 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 SQGDEAGGHGEDRPEPLS(1)PK;SQGDEAGGHGEDRPEPLS(1)PK;SQGDEAGGHGEDRPEPLS(1)PK;SQGDEAGGHGEDRPEPLS(1)PK 83.221 0.0016479 230669000.0 15626.0 18771.899999999998 21222.6 22843.0 15841.099999999999 17610.4 17040.600000000002 15411.800000000001 9683.2 14813.7 True False 15990.055397096869 16574.077221180443 18340.687487397267 18853.898866216554 14408.275301973357 17433.255364963865 15755.213822534237 15003.028999418293 16431.683167053914 16715.182692657323 0.9566186437268801 0.991558245334712 1.0972472048094335 1.1279505113933772 0.861987306205313 1.0429593074457977 0.9425690470888611 0.8975689512510594 0.9830394001180768 1.0 14.028871502877506 -6.258760532259301 24.984080358242906 0.9533734689694392 1.0434949426718463 0.3051581208661359 0.06552022877494869 310.21056938471975 2893157.8643805026 0.020285674109245914 0.02498902079045233 5.511114926806877e-07 6.258760532259301 0.09012147370240708 SQGDMQDLNGNNQSVTR ddPTM_A459_Selumetinib_30min_R1 1 SQGDMQDLNGNNQSVTR 17 0 G8JLH9;P40763;P40763-2;P40763-3 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 0 154.13 0.014314 4674700.0 603.97 491.04 577.92 575.96 639.58 544.38 668.1 408.35 224.38 546.78 False True 618.041325878958 433.5488085216972 499.4416382873276 475.37939810822087 581.7301019270201 538.9040314574925 617.7046791096042 397.5192314922627 380.7564719331998 616.9645390882201 1.0017452976994905 0.7027126861495419 0.8095143345279235 0.7705133244947261 0.9428906607610363 0.8734765084779601 1.0011996475883003 0.6443145534421406 0.617144824070278 1.0 9.269043760589016 -10.665358384910688 4.531211143777651 1.0000235959059904 0.8186810949118731 0.147382999590443 0.1311981222070899 191928917.62061098 0.1759432182065984 47250.678817951724 0.03251850830916894 2.1609345591585192e-11 10.665358384910688 -0.1813425009941173 SQGS(ph)GNEAEPLGK ddPTM_A459_Selumetinib_30min_R1 4 SQGSGNEAEPLGK 13 0 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3 B8ZZZ7 SPATS2L SPATS2-like protein 1 S(0.052)QGS(0.948)GNEAEPLGK;S(0.001)QGS(0.999)GNEAEPLGK;SQGS(1)GNEAEPLGK;SQGS(1)GNEAEPLGK 160.03 0.0003641 47735500.0 10332.1 11383.1 12521.1 13513.8 12840.5 10138.9 11075.5 11451.5 5998.37 9620.4 True False 10572.817827233117 10050.36136014038 10820.80339347912 11153.868515443555 11679.079042174399 10036.91187138464 10240.06611806379 11147.76902028566 10178.795786388928 10855.272050631538 0.9739799958876214 0.9258507122864479 0.9968247081241587 1.0275070457395534 1.075890036445004 0.9246117300948448 0.9433265302151542 1.0269451533125882 0.9376822376180564 1.0 13.406108262220958 -5.279760745781744 23.96884833977617 0.9927372470971791 0.9499153534355536 0.11833667344504795 0.04542547194515784 920.2516066524737 1203915.8055084974 0.012434829899918554 0.025971383325414835 5.250966580097852e-06 5.279760745781744 -0.04282189366162559 SQGS(ph)GNEAEPLGK ddPTM_A459_Selumetinib_30min_R2 2 SQGSGNEAEPLGK 13 0 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3 B8ZZZ7 SPATS2L SPATS2-like protein 1 S(0.043)QGS(0.957)GNEAEPLGK;SQGS(1)GNEAEPLGK 133.23 0.0013435 60975000.0 422310.0 352660.0 487180.0 479700.0 472740.0 343910.0 310640.0 386680.0 250650.0 353840.0 True False 398839.70084087533 379707.88801937475 455835.3692014781 414364.03247134393 413350.17485077796 391280.48079585214 325085.37552148226 387805.17478167947 300787.00374614977 343623.71981327137 1.1606873386319456 1.1050107024791882 1.3265538521298346 1.205865627368546 1.2029151394886146 1.1386887989236538 0.946050452215979 1.1285751024184731 0.8753383029250731 1.0 18.39047010135515 -7.08322513619869 3.7320639715040564 0.9986468795522814 1.2009003520212393 0.6185756403538528 0.07873220888072918 0.16889598375706447 4.415171196465859 0.03086140722771046 0.023927976922750768 8.25609846396586e-08 7.08322513619869 0.20225347246895797 SQGS(ph)SQFR ddPTM_A459_Selumetinib_30min_R2 3 SQGSSQFR 8 0 Q15172 Q15172 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform 1 S(0.001)QGS(0.993)S(0.006)QFR;SQGS(0.96)S(0.04)QFR;S(0.001)QGS(0.965)S(0.034)QFR 111.27 0.011672 157701000.0 102575.0 100755.7 101185.0 115688.0 118625.0 93255.0 103110.0 108699.0 102028.4 113755.0 True False 96874.29214025915 108483.33820936213 94674.86726189831 99931.09482706881 103722.26697904457 106100.02976539549 107904.8193085889 109015.29609391173 122436.93091168422 110470.59757901484 0.8769237630942401 0.9820109656940047 0.8570141679027442 0.9045944986003396 0.9389128804599479 0.9604368229248216 0.9767741070777612 0.9868263454982925 1.1083214320816033 1.0 16.75330291309021 -7.403339038569235 1.0099304141648877 1.045187308046531 0.9097048982754272 0.6091061728244647 0.0424504074910669 0.36990004390830983 0.7118681543711 0.032095467160595276 0.016347147040019796 3.950580915685983e-08 7.403339038569235 -0.13548240977110382 SQGSS(ph)QFR ddPTM_A459_Selumetinib_30min_R1 1 SQGSSQFR 8 0 Q15172 Q15172 PPP2R5A Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform 1 SQGS(0.346)S(0.654)QFR 82.417 0.043852 0.0 1575.5 2144.8 2143.4 2055.5 2046.5 2001.6 1984.8 1820.7 1309.0 1717.0 True False 1612.206084610657 1893.6858189095317 1852.3380528534362 1696.5455115137302 1861.3944363389219 1981.46572130739 1835.0849380283519 1772.409121532907 2221.277394422669 1937.3936749962952 0.8321520326083133 0.9774398684940235 0.9560979148220758 0.8756844483437133 0.9607724337917442 1.0227481109698466 0.947192592662852 0.9148420088324569 1.1465286704969329 1.0 10.919901421493003 -6.810557910220222 0.42687535631474915 1.0336705637069725 0.8929287240708645 0.3145894398745406 0.06735821501377148 1.8412108154763853 0.7064250550889392 0.06766274294399614 0.10242769649815828 1.5468282311543127e-07 6.810557910220222 -0.14074183963610798 SQIDVALS(ph)QDSTYQGER ddPTM_A459_Selumetinib_30min_R1 1 SQIDVALSQDSTYQGER 17 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 SQIDVALS(0.542)QDS(0.454)T(0.004)YQGER 260.11 3.3505e-40 81161000.0 2338.1 2762.8 2716.6 2822.0 2640.0 2326.6 2960.9 2498.1 1370.4 2087.4 True False 2392.5731808493665 2439.330091609125 2347.700641215659 2329.1906755007276 2401.2124661298567 2303.1965163837785 2737.5569291657334 2431.842273027604 2325.468709944098 2355.3381229978263 1.015808795131354 1.0356602594723832 0.9967573735135545 0.9888986437905489 1.0194767548166894 0.9778623688442307 1.1622776799797334 1.0324811751157004 0.9873184182083755 1.0 11.201718466944554 SQIDVALS(ph)QDSTYQGER ddPTM_A459_Selumetinib_30min_R2 4 SQIDVALSQDSTYQGER 17 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 SQIDVALS(0.898)QDS(0.102)TYQGER;SQIDVALS(0.87)QDS(0.128)T(0.002)YQGER;SQIDVALS(1)QDSTYQGER;SQIDVALS(0.927)QDS(0.053)T(0.02)Y(0.001)QGER 202.81 3.2249e-08 97980000.0 116946.0 120518.0 117429.0 120196.0 131880.0 113334.0 108337.8 109995.0 92939.3 124730.0 True False 110446.60949193027 129761.34307355186 109873.7459870283 103825.09745033462 115312.05537784113 128944.7297563814 113375.72236727818 110315.06723934742 111529.75694101141 121128.72081254068 0.911811903494448 1.0712681699526165 0.9070825255148973 0.8571468166580805 0.9519794694794025 1.064526471438073 0.935993723096762 0.9107259327048578 0.9207540226038987 1.0 16.886181457231785 -10.677660577839326 3.7112578155966336 1.000034840625779 0.9497820651302367 0.053857867404747295 0.065064876307651 96959878.36138923 202739437.56673357 44686.93943849298 0.016913987087351177 2.1005809479488698e-11 10.677660577839326 -0.05025277549554241 SQIDVALSQDS(ph)TYQGER ddPTM_A459_Selumetinib_30min_R1 3 SQIDVALSQDSTYQGER 17 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 SQIDVALS(0.109)QDS(0.889)T(0.002)YQGER;SQIDVALS(0.097)QDS(0.902)T(0.001)YQGER;SQIDVALS(0.051)QDS(0.949)TYQGER 307.57 5.841599999999996e-103 102835000.0 7754.3 9306.1 9435.7 10542.0 10004.0 8342.7 9186.3 8069.7 4679.3 7521.700000000001 True False 7934.960102758753 8216.537485711486 8154.383766590075 8701.037597848566 9099.139966349656 8258.780012565532 8493.369995067444 7855.6653419201975 7940.430337449955 8487.183462562394 0.9349344382338923 0.9681112140388212 0.9607879695967073 1.0251973032313368 1.072103602624669 0.9730884278625097 1.000728926449197 0.9255915553813735 0.9355789670950077 1.0 13.051070148363221 -10.458028128599842 15.722332457540212 0.9999999996384893 0.9798228297860595 0.02154376090087562 0.04297674600809654 0.0 0.0 0.045512677819442765 0.011038445762015802 3.483147544830891e-11 10.458028128599842 -0.020177169852429788 SQIDVALSQDS(ph)TYQGER ddPTM_A459_Selumetinib_30min_R2 1 SQIDVALSQDSTYQGER 17 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 SQIDVALS(0.033)QDS(0.957)T(0.01)YQGER 208.07 4.9006e-09 65259000.0 42057.0 37457.0 44208.0 48352.0 43584.0 46244.0 37916.0 36251.0 39147.0 49116.0 True False 39719.64030751035 40329.83145676201 41363.70541003107 41766.37418814759 38108.588274096386 52613.691238764186 39679.16912912866 36356.48440832391 46977.49385856984 47697.89346130636 0.832733637172716 0.8455264694127113 0.8672019330075084 0.8756439992896005 0.7989574697887016 1.103061108588488 0.8318851473245318 0.7622241103334497 0.9848966159622767 1.0 15.541637931733375 SQIHDIVLVGGS(ph)TR ddPTM_A459_Selumetinib_30min_R2 2 SQIHDIVLVGGSTR 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PNE6;A8K7Q2 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 SQIHDIVLVGGS(0.785)T(0.215)R;SQIHDIVLVGGS(0.82)T(0.18)R 119.37 0.0014705 10062700.0 53686.0 55697.0 76908.0 97912.0 102212.0 68145.0 63171.0 80167.0 78817.0 81705.0 True False 50702.34704208579 59968.78080591811 71959.82301109903 84576.21669237879 89371.21477312628 77531.35519128067 66108.57667096176 80400.27269763868 94582.60233098056 79345.96435491579 0.6390034761603421 0.7557886691965426 0.9069121989521932 1.0659170555173794 1.126348586216274 0.9771304164189328 0.8331687340172339 1.0132874853975804 1.1920278882478639 1.0 16.2758692270181 -5.257884438855905 1.9748551155842666 1.0232765705733393 0.6476268151239793 0.681140893300987 0.09110174422679888 0.2417146738685884 1.6863115747609265 0.027968215134325555 0.11368902490926432 5.522243607637645e-06 5.257884438855905 -0.37564975544935997 SQIHDIVLVGGSTR ddPTM_A459_Selumetinib_30min_R1 2 SQIHDIVLVGGSTR 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PNE6;A8K7Q2 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 ; 141.82 0.00077446 28852700.0 7135.4 8924.9 9235.2 9114.0 9690.4 7933.200000000001 8847.7 7882.5 3853.7799999999997 7125.6 False True 7301.640936928515 7879.968558926552 7981.1105653224095 7522.410990968687 8813.905030979078 7853.399210769281 8180.310865675864 7673.430494031498 6539.583191045217 8040.240169221661 0.9081371679517073 0.9800663155674585 0.9926457913377262 0.9355953096730564 1.096224098468978 0.9767617689869994 1.0174212080119696 0.9543782688738175 0.8133566974875931 1.0 12.973022881311318 -8.008706162120374 24.31467125173117 0.8990747171021163 0.988344570461156 0.20244441390730705 0.06281229040237886 367.12664001626393 1025308.0107917007 0.035393110390002876 0.015612529128844536 9.801529195674897e-09 8.008706162120374 0.0892698533590397 SQIHDIVLVGGSTR ddPTM_A459_Selumetinib_30min_R2 1 SQIHDIVLVGGSTR 14 0 P11142;E9PKE3;P11142-2;E9PN89;E9PNE6;A8K7Q2 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 122.33 0.0025155 11518000.0 87916.0 68927.0 125320.0 133970.0 152110.0 108710.0 94032.0 105990.0 100380.0 131870.0 False True 83029.98067563273 74213.47926476336 117257.04763809904 115723.05488885957 133000.58191934656 123683.8157288742 98404.67432087309 106298.413352411 120458.80485154018 128062.57046059286 0.6483547876401757 0.5795095241165737 0.9156230990551695 0.9036446361543994 1.038559365480433 0.9658076929428331 0.7684108945099924 0.8300505992507851 0.9406246057555708 1.0 16.966489347450747 -5.265289200055065 24.822847467915743 0.9140941471650048 0.6139321406430028 0.7244490226211953 0.07551017222299522 150.18703368760427 968382.580510215 0.02134362682187565 0.04726644445418489 5.428886973151399e-06 5.265289200055065 -0.300162006522002 SQIMLDMLT(ph)ENLFFDTGMGKS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 SQIMLDMLTENLFFDTGMGKSK 22 1 C9JKF1;Q5K651 C9JKF1 SAMD9 Sterile alpha motif domain-containing protein 9 2 S(0.089)QIMLDMLT(0.91)ENLFFDT(0.015)GMGKS(0.985)K 58.339 0.011971 58451000.0 2317.1 2965.8 2930.9 2729.7 2606.7 2396.8 2556.4 2395.6 1641.2 2007.2 True False 2371.0839217082525 2618.5627572369876 2532.8998782812996 2253.0091378151437 2370.9244452502644 2372.6903681202803 2363.5686898305526 2332.060905994527 2784.9965314946417 2264.843671783671 1.0469084251810246 1.156178145918012 1.1183552798090128 0.9947746795436847 1.0468380112888982 1.0476177220000684 1.0435902129921093 1.0296785314802408 1.2296639128745366 1.0 11.14519575801268 -8.180001103513398 0.005104343177000936 6.53279165527704e-08 2.1258561236995153 0.027552158783202163 0.06951450022159184 19697.48401957447 92.68617421607858 19351.046844932513 19242.879432292062 6.606917692316139e-09 8.180001103513398 2.125856058371599 SQIMLDMLT(ph)ENLFFDTGMGKS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 SQIMLDMLTENLFFDTGMGKSK 22 1 C9JKF1;Q5K651 C9JKF1 SAMD9 Sterile alpha motif domain-containing protein 9 2 S(0.007)QIMLDMLT(0.857)ENLFFDT(0.17)GMGKS(0.967)K 49.655 0.035355000000000004 2485500.0 5000.4 6018.7 7832.7 8939.5 10741.0 8287.6 6200.8 8018.6 7001.9 8324.3 True False 4722.497786187194 6480.314936829255 7328.752609598949 7721.924678502345 9391.619554241675 9429.141672657686 6489.149486652102 8041.932798449313 8402.475649432152 8083.9558298711645 0.5841815424989101 0.8016267126155899 0.906579991755812 0.9552160898713633 1.1617603747336842 1.1664019288447744 0.8027195624540566 0.994801674785682 1.039401479456879 1.0 12.980845723623684 -4.879001981755636 1.1748758186670634 1.020285023505851 0.43525024653992916 0.6625321158940338 0.09770021346258427 0.8769643796409445 1.1531631621291114 0.032911733315022756 0.6065128290062255 1.3212896049156445e-05 4.879001981755636 -0.5850347769659218 SQLDDHPES(ph)DDEENFIDANDDEDMEK ddPTM_A459_Selumetinib_30min_R1 3 SQLDDHPESDDEENFIDANDDEDMEK 26 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 SQLDDHPES(1)DDEENFIDANDDEDMEK;SQLDDHPES(1)DDEENFIDANDDEDMEK;SQLDDHPES(1)DDEENFIDANDDEDMEK 133.07 3.4642e-09 43565700.0 3616.6899999999996 4833.74 2777.0 2864.53 3142.65 3717.6899999999996 4399.59 4374.72 1991.25 4156.93 True False 3700.951840146312 4267.803473655241 2399.8986529691106 2364.2936093877024 2858.397862379923 3680.293413992444 4067.7253841697684 4258.688214506751 3379.005814854194 4690.5124574271085 0.7890293168896941 0.9098799997636641 0.5116495638273029 0.5040586995231201 0.6093999085012223 0.7846250164339611 0.8672240871525244 0.9079366600473274 0.7203916087044534 1.0 12.19552983627277 -6.964881179337082 4.002621001736038 0.8631231811784105 0.6616389196264024 0.36370102427623985 0.13017811322018602 0.2793881888161136 9.806662151708261 0.05340742717854523 0.04518480955666572 1.0842235112380262e-07 6.964881179337082 -0.20148426155200805 SQLDDHPES(ph)DDEENFIDANDDEDMEK ddPTM_A459_Selumetinib_30min_R2 5 SQLDDHPESDDEENFIDANDDEDMEK 26 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 SQLDDHPES(1)DDEENFIDANDDEDMEK;S(0.002)QLDDHPES(0.998)DDEENFIDANDDEDMEK;S(0.002)QLDDHPES(0.998)DDEENFIDANDDEDMEK;S(0.003)QLDDHPES(0.997)DDEENFIDANDDEDMEK;SQLDDHPES(1)DDEENFIDANDDEDMEK 144.33 2.8337e-10 66025400.0 321514.7 209624.8 282331.4 308142.5 283038.0 290216.0 366054.0 370175.2 306682.1 250391.8 True False 303646.20009932015 225702.34811003137 264166.50510318635 266172.95992453815 247480.23604817552 330190.61968145455 383076.23632224 371252.34854619624 368027.08941383276 243162.3381379733 1.248738609870693 0.9281961583292766 1.0863791947636852 1.094630698005167 1.01775726431678 1.3579019769669278 1.5753929628069203 1.526767473076127 1.5135036627465297 1.0 17.891560270697227 -6.8633421919317374 4.546071916111347 1.4497413388377254 1.0690487196981833 0.46375723801071467 0.16893334488062925 0.16194995502989468 5.7828671432398835 0.057352764350149625 0.050704934188359654 1.3698020381509832e-07 6.8633421919317374 -0.3806926191395421 SQLDDHPES(ph)DDEENFIDANDDEDMEKFTDADK ddPTM_A459_Selumetinib_30min_R1 1 SQLDDHPESDDEENFIDANDDEDMEKFTDADK 32 1 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 S(0.021)QLDDHPES(0.979)DDEENFIDANDDEDMEKFT(0.001)DADK 75.005 7.9662e-06 4311100.0 323.89 332.97 355.56 294.96 407.1 307.44 499.93 523.39 220.26 267.36 True False 331.4360068197687 293.98571760644677 307.27690495127734 243.45077308493768 370.27787687934244 304.34743273318537 462.2198776040477 509.5079969896792 373.76513284609416 301.67826030693635 1.0986406726243911 0.9745008384340889 1.0185583297869882 0.806988123165533 1.2273933047167893 1.0088477453547144 1.5321617047704121 1.688911877413012 1.2389528249924755 1.0 8.236866925777333 -7.252580106101634 24.587868279732366 1.4224159255758684 1.019646688608814 0.40639966752999823 0.1979738614419053 428.8543651453765 1190236.7947407742 0.07406688778781656 0.056475766272609744 5.590104079672747e-08 7.252580106101634 -0.40276923696705436 SQLPTLEQDGGTQNPVS(ph)SPGMSQELR ddPTM_A459_Selumetinib_30min_R1 1 SQLPTLEQDGGTQNPVSSPGMSQELR 26 0 P46937-6;P46937-7;P46937;P46937-9;P46937-5;P46937-3;P46937-2;P46937-8;H0YCI3;P46937-4 P46937-6 YAP1 Transcriptional coactivator YAP1 1 SQLPTLEQDGGTQNPVS(0.476)S(0.476)PGMS(0.048)QELR 94.732 0.00032709 0.0 726.73 625.63 870.28 635.68 839.39 838.76 649.97 577.55 469.98 593.6 True False 743.6613950295799 552.3809487525037 752.1007561058542 524.670421191461 763.4673227063413 830.3228359331468 600.942239606151 562.2314978532049 797.5217340189197 669.7943421536403 1.1102831842956888 0.8247023212772918 1.1228831131770505 0.7833306257924613 1.1398533470012708 1.2396683335116674 0.8972041144359268 0.8394091476578013 1.1906964329596872 1.0 9.38757437922431 -4.468673379764481 22.113902713137307 1.0020757561268856 2.820132442665451 0.039961573983290144 0.15568514301873523 821.8506950067009 454634.1619480256 0.03696665162504351 25469.76013787873 3.398807909417743e-05 4.468673379764481 1.8180566865385654 SQLQALHIGLDS(ph)SSIGSGPGDAEADDGFPESR ddPTM_A459_Selumetinib_30min_R1 1 SQLQALHIGLDSSSIGSGPGDAEADDGFPESR 32 0 E9PF63;O75116;Q14DU5 E9PF63 ROCK2 Rho-associated protein kinase 2 1 SQLQALHIGLDS(0.333)S(0.333)S(0.333)IGS(0.001)GPGDAEADDGFPESR 128.71 6.447299999999999e-19 18751000.0 762.45 894.84 867.43 979.4 1178.4 828.26 815.56 844.45 380.97 484.97 True False 780.2136015305589 790.0717168001704 749.6377704519251 808.3661756149586 1071.8139280634175 819.9284563999097 754.0416525888774 822.0524428398222 646.4782650521038 547.2206235078351 1.4257752138966815 1.44379009646163 1.369900435488963 1.4772216924740675 1.9586504638527598 1.4983507952312585 1.377948162397942 1.5022322031107662 1.1813850525369454 1.0 9.095978792936771 -8.415381585889365 1.6677695274288422 0.994783327229171 1.5193554902998132 0.5344628617116209 0.15919896686722326 0.30052599226852056 1.7714461953896747 0.16287048992666242 0.04756643198508608 3.842540150455197e-09 8.415381585889365 0.5245721630706423 SQLQALHIGLDS(ph)SSIGSGPGDAEADDGFPESR ddPTM_A459_Selumetinib_30min_R2 1 SQLQALHIGLDSSSIGSGPGDAEADDGFPESR 32 0 E9PF63;O75116;Q14DU5 E9PF63 ROCK2 Rho-associated protein kinase 2 1 SQLQALHIGLDS(0.524)S(0.218)S(0.218)IGS(0.04)GPGDAEADDGFPESR 60.637 0.0043424 0.0 3178.1 2397.7 3866.8 2430.5 3739.4 2991.1 3599.1 2555.4 2274.6 3569.6 True False 3001.4739249423105 2581.595880179359 3618.014297853511 2099.461707153639 3269.6231413398464 3403.096874497613 3766.4652814813535 2562.8357909307565 2729.5835576341237 3466.5363730653758 0.8658423284588757 0.7447191093213642 1.0436971975730884 0.605636716656498 0.9431959712710576 0.9816994568236235 1.086521206223709 0.7393073417154142 0.787409466937287 1.0 11.75927918292591 SQLQALHIGLDSS(ph)SIGSGPGDAEADDGFPESR ddPTM_A459_Selumetinib_30min_R1 1 SQLQALHIGLDSSSIGSGPGDAEADDGFPESR 32 0 E9PF63;O75116;Q14DU5 E9PF63 ROCK2 Rho-associated protein kinase 2 1 SQLQALHIGLDS(0.095)S(0.453)S(0.453)IGSGPGDAEADDGFPESR 152.0 4.8679e-21 17835000.0 949.23 1138.4 1004.5 1290.7 1442.4 1271.7 1015.0 1079.0 463.57 932.12 True False 971.3452121199451 1005.1155987721985 868.0944173235398 1065.3034744396846 1311.9351746764028 1258.9078526112146 938.4377328188116 1050.3814149140478 786.6444321867965 1051.7666816176743 0.9235367777822772 0.9556450269239144 0.8253678619942243 1.0128705282821757 1.2473633150829375 1.196945933555288 0.8922489647375437 0.9986829144449643 0.7479267464309619 1.0 10.038598984914012 SQLQALHIGLDSSS(ph)IGSGPGDAEADDGFPESR ddPTM_A459_Selumetinib_30min_R2 1 SQLQALHIGLDSSSIGSGPGDAEADDGFPESR 32 0 E9PF63;O75116;Q14DU5 E9PF63 ROCK2 Rho-associated protein kinase 2 1 SQLQALHIGLDS(0.073)S(0.26)S(0.651)IGS(0.015)GPGDAEADDGFPESR 93.207 3.5615e-08 4787500.0 10507.0 7607.9 12397.0 12182.0 13362.0 9277.0 7508.8 10188.0 7628.9 10216.0 True False 9923.063002853547 8191.401466745859 11599.390516833035 10522.790584877861 11683.346102204374 10554.82254177872 7857.974078404934 10217.645393285804 9154.893169275894 9921.0375356443 1.000204158809194 0.8256597596083872 1.169171114932158 1.0606542457955213 1.177633494503821 1.0638829360192779 0.7920516428017541 1.0298968587283186 0.9227757819062974 1.0 13.276275289271856 SQMS(ph)PQGLR ddPTM_A459_Selumetinib_30min_R1 1 SQMSPQGLR 9 0 P16144-4;P16144-2;P16144-3;P16144;P16144-5 P16144-4 ITGB4 Integrin beta-4 1 SQMS(1)PQGLR 86.01100000000002 0.034412 3315800.0 307.2 249.26 186.5 304.85 422.79 404.61 325.74 311.48 226.62 248.27 True False 314.3571622928556 220.07652332216975 161.17432437117 251.61367024323062 384.54871914963735 400.5399907564866 301.16916954522156 303.2185385703686 384.5575883300725 280.1378728545895 1.1221516001730627 0.7856007510858924 0.575339288218378 0.8981779852873915 1.372712354924049 1.4297959311070871 1.0750748068310947 1.082390379710492 1.3727440149789527 1.0 8.129993229545278 -6.133476825538735 5.473466287549682 1.2278092396986406 0.8111097044834163 0.5062014169703362 0.18265222717048435 0.18711386950078726 7.5610730543025335 0.05599937431947978 0.073082031334647 7.353992361913852e-07 6.133476825538735 -0.4166995352152243 SQNRPQGQSTQPSNAAGTNTTSAST(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SQNRPQGQSTQPSNAAGTNTTSASTPR 27 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 SQNRPQGQSTQPSNAAGT(0.023)NT(0.055)T(0.042)S(0.032)AS(0.245)T(0.602)PR;SQNRPQGQSTQPSNAAGT(0.003)NT(0.01)T(0.086)S(0.147)AS(0.214)T(0.539)PR 96.382 3.257799999999999e-06 2323200.0 312.61 214.54 293.84 318.06 202.9 184.56 368.15999999999997 512.46 0.0 304.54 True False 319.8932047668278 189.42155706305982 253.93814194758482 262.5167917256419 184.5477308249045 182.7034939670723 340.38939479268333 498.86789609532264 0.0 343.63067547080453 0.9309215608546755 0.5512358778899337 0.7389856612762147 0.7639503992650557 0.5370525508878325 0.5316856352150525 0.9905675455962121 1.4517560034820214 0.0 1.0 8.424715019540503 -7.268875459372199 24.224479494157833 0.8982272184876693 0.6705781605739848 0.05687693093838009 0.3556163924117229 1016.5867447530267 3311710.7861982565 0.14086301709347945 0.09717445963706642 5.384241617962958e-08 7.268875459372199 -0.2276490579136845 SQNRPQGQSTQPSNAAGTNTTSAST(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 SQNRPQGQSTQPSNAAGTNTTSASTPR 27 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 SQNRPQGQSTQPSNAAGTNTTS(0.003)AS(0.07)T(0.927)PR;SQNRPQGQSTQPSNAAGT(0.001)NT(0.007)T(0.02)S(0.015)AS(0.24)T(0.718)PR;SQNRPQGQSTQPSNAAGT(0.008)NT(0.025)T(0.022)S(0.068)AS(0.234)T(0.644)PR 148.61 1.1613e-13 3349380.0 1252.06 522.45 1260.6 1608.7199999999998 1548.6100000000001 1092.23 503.03 1153.24 0.0 528.85 True False 1182.4755175933003 562.5202350584754 1179.4943684375037 1389.6095608032103 1354.0597670509442 1242.674768223237 526.4218917350349 1156.5957374708403 0.0 513.5807263826828 2.3024141227453425 1.0952907812964274 2.2966094867793596 2.705727628430852 2.636508142717953 2.4196289003596423 1.025003207271419 2.2520232517624303 0.0 1.0 9.004447251904203 -7.960185418023855 1.398185419811574 0.628929813467551 2.1816755429730446 0.44794221220838193 0.6467784973485421 0.41307199030640407 1.4510464328378818 0.5770449420867941 0.19838771689438597 1.0960101648073328e-08 7.960185418023855 1.5527457295054936 SQPAPVS(ph)PQQK ddPTM_A459_Selumetinib_30min_R1 3 SQPAPVSPQQK 11 0 Q13118-2;Q13118 Q13118-2 KLF10 Krueppel-like factor 10 1 SQPAPVS(1)PQQK;SQPAPVS(1)PQQK;SQPAPVS(1)PQQK 185.66 1.902e-05 20979200.0 8537.2 9982.5 11214.3 11714.4 9619.0 8689.4 8424.699999999999 8805.4 5566.1 8063.300000000001 True False 8736.10014950054 8813.744259261657 9691.459655740544 9668.699946522225 8748.963148372379 8601.99252534394 7789.2180962351185 8571.852188029807 9445.265168140579 9098.30309819314 0.9601900546966246 0.9687239657922592 1.0651941962304157 1.0626926628155926 0.9616038346875762 0.9454502045609181 0.8561176751499961 0.9421374618451782 1.0381348110964057 1.0 13.151381781610448 -6.451444391530704 7.835397930334941 0.9472237337979603 1.014553220068662 0.20128850008522847 0.054147020251815337 0.47053389923193173 46.82325964376314 0.018036982246870423 0.020400334349144896 3.5363529880833887e-07 6.451444391530704 0.06732948627070168 SQPAPVS(ph)PQQK ddPTM_A459_Selumetinib_30min_R2 2 SQPAPVSPQQK 11 0 Q13118-2;Q13118 Q13118-2 KLF10 Krueppel-like factor 10 1 SQPAPVS(1)PQQK;S(0.011)QPAPVS(0.989)PQQK 123.68 0.0037932 33546000.0 52170.0 46493.0 52672.0 58986.0 63598.0 42457.0 51081.0 45755.0 37532.0 52844.0 True False 49270.600253056975 50058.86360144263 49283.14086493748 50952.00504347444 55608.25066666623 48305.06636372743 53456.36771508125 45888.139474851996 45039.448731699595 51318.256414799085 0.9600988750437824 0.9754591659705478 0.9603432444506295 0.9928631368851607 1.0835958692203347 0.9412842473306884 1.041663755740259 0.8941874233595131 0.8776496295519344 1.0 15.647184533912064 -10.433612879441979 4.585747171410873 1.0000002686309921 0.9726715555158326 0.021515790929359624 0.058278423004723905 2621933566311.958 623259821185.6056 8084592.279352072 0.014585935851714735 3.6845726201318677e-11 10.433612879441979 -0.027328713115159498 SQPDPVDT(ph)PTSSKPQSK ddPTM_A459_Selumetinib_30min_R1 2 SQPDPVDTPTSSKPQSK 17 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.003)QPDPVDT(0.962)PT(0.028)S(0.006)S(0.001)KPQSK;S(0.001)QPDPVDT(0.956)PT(0.042)S(0.001)SKPQSK 120.41 0.0020314 14894200.0 5201.4 11771.0 9902.5 12259.900000000001 8704.0 8963.6 10359.8 7108.6 4362.0 7058.1 True False 5322.58249983743 10392.84584781056 8557.794890538933 10118.938611825433 7916.72473681601 8873.43432229762 9578.351945277169 6920.056836012977 7401.995412125041 7964.075886715988 0.6683239305536318 1.3049656979218065 1.0745496416995803 1.2705728518614114 0.9940544074951672 1.1141825427729077 1.2026947107892052 0.868908952456816 0.929423013719835 1.0 12.959291252690269 -7.770543983902505 24.99497221207069 0.9243744637890436 1.101782945409836 0.14904829566470967 0.17004858069139714 332.1452021498309 911826.1455959111 0.08614771351118164 0.0423049803450217 1.6961178163829307e-08 7.770543983902505 0.17740848162079237 SQPDPVDT(ph)PTSSKPQSK ddPTM_A459_Selumetinib_30min_R2 2 SQPDPVDTPTSSKPQSK 17 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 SQPDPVDT(0.578)PT(0.261)S(0.08)S(0.08)KPQSK;S(0.004)QPDPVDT(0.838)PT(0.114)S(0.022)S(0.022)KPQSK 156.06 0.00199 22925000.0 81941.0 87264.0 85264.0 74471.0 76259.0 72487.0 71987.0 69538.0 55765.5 96516.0 True False 77387.04725581245 93956.8682020149 79778.20706842393 64327.92133035953 66678.66265589015 82471.42627852905 75334.53813953442 69740.3440673644 66920.15821825626 93729.33230131608 0.8256438550851154 1.0024275847817559 0.8511551838645045 0.68631579625001 0.7113958994345028 0.8798891900072892 0.8037455969210677 0.7440610356976283 0.7139724201077725 1.0 16.516212984994006 -5.524028963917708 24.985664783462838 0.7805654723824432 0.9172246471821518 0.2008838004947472 0.09676531031612651 46.53258121349374 1010801.2729016853 0.025215028627874447 0.04412942641900442 2.9920650834930708e-06 5.524028963917708 0.13665917479970857 SQPLTS(ph)PESR ddPTM_A459_Selumetinib_30min_R1 2 SQPLTSPESR 10 0 P46939;P46939-2 P46939 UTRN Utrophin 1 SQPLT(0.454)S(0.546)PESR;SQPLT(0.143)S(0.857)PESR 138.2 0.0016624000000000005 30440000.0 12620.599999999999 12858.7 13899.0 14474.3 13650.8 10978.0 12812.1 12752.7 6988.9 9714.2 True False 12914.63542458728 11353.197426152548 12011.592141742047 11946.635221261575 12416.087550244481 10867.571287226488 11845.672981919111 12414.456969392377 11859.652850940094 10961.112194320915 1.1782230849966584 1.035770570073608 1.0958369852254042 1.089910860273036 1.1327397557957126 0.9914661117014302 1.0806999118261464 1.1325909952663797 1.081975317895635 1.0 13.420106571627406 -4.7467013355396075 24.941886402156136 1.076444256873902 1.1782233592494518 0.3172559321023989 0.04652647884097171 991.1092086925628 1677205.1584468537 0.011327343095459276 0.24950205242594536 1.791837677793984e-05 4.7467013355396075 0.10177910237554966 SQPLTS(ph)PESR ddPTM_A459_Selumetinib_30min_R2 2 SQPLTSPESR 10 0 P46939;P46939-2 P46939 UTRN Utrophin 1 SQPLT(0.436)S(0.564)PESR;SQPLT(0.224)S(0.776)PESR 147.58 0.00081938 23009000.0 198081.0 186674.0 233490.0 275230.0 247060.0 207740.0 221070.0 248870.0 231620.0 234320.0 True False 187072.45100106913 200991.2955484851 218467.5076046908 237743.1992017679 216022.11405557662 236354.2993240392 231350.19304189438 249594.1704973534 277950.4720035234 227554.57276352556 0.8220992825113411 0.8832663440139039 0.9600664357192328 1.0447744306541813 0.949320030936344 1.0386708403775224 1.016680043966039 1.0968541192829877 1.2214673105794678 1.0 17.795853052335865 -4.000406200154248 0.36857414722711335 1.0980708837540514 0.40003520627275974 0.6398640982213591 0.06337810726082127 7.070440571562097 0.48994875721333586 0.05575087835768671 2.44822911569854 9.990651268465108e-05 4.000406200154248 -0.6980356774812917 SQPS(ph)SSVPSSYIR ddPTM_A459_Selumetinib_30min_R1 1 SQPSSSVPSSYIR 13 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 SQPS(0.685)S(0.151)S(0.151)VPS(0.005)S(0.005)Y(0.004)IR 78.903 0.026567 55507000.0 4100.3 5624.0 5149.1 5288.7 4993.6 5104.6 5442.2 5100.6 2449.0 4086.5 True False 4195.829012205064 4965.53946547333 4449.8805019817255 4365.127826194435 4541.929761691685 5053.252358605971 5031.6904724596425 4965.315518916213 4155.774132116973 4611.042080880815 0.9099524442864256 1.076880101802237 0.9650487729081181 0.9466683993828562 0.985011561816862 1.0959024597842497 1.0912263180861004 1.076831534351932 0.901265713741464 1.0 12.170877116666762 -6.6052821640182025 12.135845312192997 1.0414567540424104 0.979331696001719 0.1478762954320504 0.066079562252062 1.0949545260239912 156.22031059061058 0.021884134583154597 0.02188139231746219 2.4815203211492323e-07 6.6052821640182025 -0.06212505804069146 SQPVT(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 SQPVTPEK 8 0 P54274;P54274-2 P54274 TERF1 Telomeric repeat-binding factor 1 1 S(0.003)QPVT(0.997)PEK;SQPVT(1)PEK 107.97 0.030581 20099800.0 13860.8 18498.2 13375.5 14382.5 13643.3 13895.5 14143.5 13827.8 7911.0 13651.5 True False 14183.729671578161 16332.42214442014 11559.180566362385 11870.86636796215 12409.265923920253 13755.723886104546 13076.644408002827 13461.041824975418 13424.38920342073 15403.803001870649 0.9207940188442867 1.0602850570366757 0.7504108280895718 0.7706451690222565 0.8055975477233293 0.8930082970052292 0.8489231137541028 0.8738778224663546 0.8714983697071731 1.0 13.91099895739179 -10.108421882115952 14.706470432214603 0.9999987017601317 0.8643490740296874 0.19149918315583492 0.08245741298757872 0.0 0.0 0.08557998362934292 0.02075619482014183 7.790729361961601e-11 10.108421882115952 -0.1356496277304443 SQPVT(ph)PEK ddPTM_A459_Selumetinib_30min_R2 1 SQPVTPEK 8 0 P54274;P54274-2 P54274 TERF1 Telomeric repeat-binding factor 1 1 SQPVT(1)PEK 125.97 0.011587 28980000.0 80828.0 75484.0 86565.0 95222.0 82537.0 62444.0 83683.0 92161.0 68717.0 86967.0 True False 76335.90334012051 81273.38008068533 80995.50214484552 82252.59933288798 72167.96416985802 71045.09418980591 87574.42531471868 92429.17325192511 82462.32011340182 84456.03674259775 0.9038537241899534 0.9623158179726996 0.9590256098767798 0.9739102437825099 0.8545033244906945 0.8412080051344908 1.0369232170060863 1.0944057620608887 0.9763934384551775 1.0 16.365912927115417 -7.290178999721248 24.176702312427217 1.0347977946933193 0.9197366004729531 0.5381381285630582 0.05014516071393546 398.3212103901731 335078.69073095673 0.022463608351120545 0.01514858748814057 5.1265004552740665e-08 7.290178999721248 -0.1150611942203662 SQQQPT(ph)PVTPK ddPTM_A459_Selumetinib_30min_R1 3 SQQQPTPVTPK 11 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 SQQQPT(0.962)PVT(0.038)PK;SQQQPT(0.899)PVT(0.101)PK;S(0.025)QQQPT(0.974)PVT(0.001)PK 174.46 0.00030539 284423000.0 29475.6 35060.7 40800.0 41198.0 28148.6 30078.9 29215.4 27743.4 18462.4 26706.9 True False 30162.324130466426 30955.776944722777 35259.58409835783 34003.54268223916 25602.56410003896 29776.333575456065 27011.658856546514 27007.55490873624 31329.344359655526 30134.990762235622 1.0009070309145427 1.0272369813869577 1.170054584604161 1.1283740868058107 0.849595883471231 0.9880983143612236 0.8963553056865978 0.896219120218925 1.0396334482676077 1.0 14.879152002089317 -6.2500619321030815 24.945270963464424 0.939518946212357 1.084072119105565 0.4850624009012876 0.06882389364879007 613.4522550254759 1345005.2264530312 0.020755761602252832 0.0265515511698716 5.622611388208336e-07 6.2500619321030815 0.1445531728932079 SQQQPT(ph)PVTPK ddPTM_A459_Selumetinib_30min_R2 4 SQQQPTPVTPK 11 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 SQQQPT(0.999)PVT(0.001)PK;SQQQPT(0.72)PVT(0.28)PK;S(0.001)QQQPT(0.945)PVT(0.054)PK;SQQQPT(0.984)PVT(0.016)PK 168.82 0.0010685 484380000.0 785180.0 748370.0 725930.0 731570.0 708040.0 552110.0 655550.0 659430.0 477860.0 672420.0 True False 741542.838924578 805767.572611181 679224.4541328244 631928.9039713576 619089.6852420885 628158.1409444264 686034.3739476814 661348.8321254866 573445.3525239779 653005.4874430235 1.135584391225012 1.2339369088096468 1.0401512195440603 0.967723726864539 0.9480619951085875 0.9619492531435043 1.0505797993122374 1.012776837014239 0.8781631449521511 1.0 19.31673558975151 -5.434421248983543 3.922821603861528 0.9773627073877403 1.183166754306717 0.7458478937955008 0.04841636376341745 0.1096248711023348 3.057393549867457 0.0131415854806386 0.02884980930079676 3.6777207577982534e-06 5.434421248983543 0.2058040469189767 SQQQPTPVT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SQQQPTPVTPK 11 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 S(0.001)QQQPT(0.226)PVT(0.773)PK;S(0.001)QQQPT(0.34)PVT(0.659)PK 104.41 0.028827 11878700.0 60126.0 60772.0 60164.0 58004.0 54485.0 43454.0 51997.0 48913.0 35104.0 54070.0 True False 56784.43762344837 65433.01698722109 56293.1137416103 50103.755137518914 47640.107197919875 49439.39406386255 54414.96353010082 49055.32873201693 42125.78088771137 52508.858609268565 1.0814258608436997 1.2461329139550412 1.072068889565879 0.9541962340174518 0.9072775234446006 0.9415438722778824 1.0363006351940736 0.9342295763282495 0.8022604566817906 1.0 15.680273215538495 -5.62351697584886 3.162435031327948 0.9385643545048675 1.1644407726051595 0.6398898489561768 0.06873661525129271 0.1471016620551005 2.913141023442445 0.019344739420325746 0.03717232362713121 2.379485289016833e-06 5.62351697584886 0.22587641810029202 SQQQQSLMES(ph)MQPGK ddPTM_A459_Selumetinib_30min_R2 1 SQQQQSLMESMQPGK 15 0 A8MVX0;A8MVX0-2 A8MVX0 ARHGEF33 Rho guanine nucleotide exchange factor 33 1 SQQQQS(0.118)LMES(0.882)MQPGK 93.478 0.021299 0.0 17432.0 13298.0 16261.0 18280.0 19407.0 13900.0 16017.0 12097.0 11677.0 14847.0 True False 16463.199225824977 14317.91384019064 15214.784963638138 15790.232465241113 16968.919159218698 15814.598828363074 16761.822237083394 12132.200267233846 14012.72628264032 14418.328532861291 1.1418243930496628 0.9930356218169262 1.055239165133574 1.0951499980911845 1.176899189149718 1.0968399556383734 1.1625357404556962 0.8414429064771929 0.9718689826427142 1.0 13.815616307157292 -7.7562060866965075 24.99996287681594 0.9299919528862749 1.0992975465954302 0.5906084361546484 0.06291374869688177 86.45054609680396 412988.8658041094 0.03116278717844037 0.017301226906792373 1.7530484265860307e-08 7.7562060866965075 0.16930559370915532 SQQTSFQS(ph)SPCNKSPK ddPTM_A459_Selumetinib_30min_R1 1 SQQTSFQSSPCNKSPK 16 1 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 S(0.001)QQT(0.005)S(0.012)FQS(0.722)S(0.255)PCNKS(0.004)PK 64.5 0.032001 7588400.0 890.52 973.56 1279.9 1732.0 1047.5 1146.3 859.18 1029.6 683.53 976.78 True False 911.2673833497189 859.5751426042345 1106.096609987455 1429.53871366664 952.7538099511454 1134.769262757125 794.3713608702135 1002.2916633878629 1159.9004869440237 1102.1592276429128 0.8268019361399923 0.7799010533555386 1.0035724260576784 1.2970346550778 0.8644429825159772 1.0295874083311467 0.7207410154057894 0.9093891683249546 1.0523892173226157 1.0 10.106116948077997 -5.261504978680196 24.680732748309836 0.9804523541076492 0.8033514838517747 0.21127920007643042 0.13992431870838454 7.826227856426183 2946375.0864461423 0.038240587829134344 0.08877334241212878 5.476398228734482e-06 5.261504978680196 -0.1771008702558745 SQQTSFQSS(ph)PCNK ddPTM_A459_Selumetinib_30min_R1 1 SQQTSFQSSPCNK 13 0 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 SQQTSFQS(0.026)S(0.974)PCNK 143.05 0.001131 0.0 1043.6 1332.5 1189.3 955.11 1461.2 1160.6 1045.1 842.36 549.15 778.81 True False 1067.9138495078907 1176.4902805375561 1027.7995923572782 788.3179681351879 1329.0347179958128 1148.9254177404864 966.267265585163 820.0178764290985 931.8674416709008 878.7778497518135 1.2152261800971582 1.338780080619719 1.1695784010117594 0.8970617185649667 1.512367111177372 1.3074128098073576 1.099558057657073 0.9331344396774336 1.0604129837069527 1.0 9.779354695794508 -7.489947813260724 4.748723820309093 0.998981497685939 1.2370198506601233 0.35321722848467196 0.1483644129849723 0.23936486273087623 13.285179229345735 0.07029048991462086 0.043945607997374264 3.2363254370617306e-08 7.489947813260724 0.2380383529741843 SQQTSFQSSPCNKS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SQQTSFQSSPCNKSPK 16 1 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 SQQTS(0.002)FQS(0.099)S(0.368)PCNKS(0.53)PK 83.395 0.010208 9338000.0 1448.5 1804.7 2389.8 2492.3 1421.5 1621.9 1499.2 1373.6 1028.5 1458.0 True False 1482.2472317096394 1593.4048850177317 2065.278286231753 2057.066591265225 1292.9255759862083 1605.5851585673738 1386.1141369871557 1337.1676659183836 1745.2893813320966 1645.1485021226536 0.9009808110314476 0.9685477529608059 1.2553749911129766 1.2503835298826178 0.7859020473337274 0.9759515061988427 0.8425465149186966 0.8127945071178088 1.0608704193452665 1.0 10.684002101817805 -6.268114427944337 24.95895887335861 0.9032743790933903 1.096413143719019 0.31587484897397555 0.12986308287168802 641.5688145152321 2398914.1957943426 0.04206373457183156 0.04880566910517476 5.393684909390078e-07 6.268114427944337 0.19313876462562873 SQQTSFQSSPCNKS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SQQTSFQSSPCNKSPK 16 1 Q12986-3;Q12986-2;Q12986 Q12986-3 NFX1 Transcriptional repressor NF-X1 1 SQQT(0.002)S(0.009)FQS(0.258)S(0.258)PCNKS(0.473)PK 62.303 0.03622 15703000.0 45171.0 42945.0 33938.0 37781.0 34949.0 28386.0 34494.0 27665.0 17460.0 36630.0 True False 42660.576653840064 46238.7434100607 31754.46602890052 32635.16262413976 30558.394171975822 32295.913837547792 36098.039348564314 27745.5005698127 20952.487873160906 35572.39672383033 1.1992606791451104 1.299848974727218 0.8926715361753474 0.917429401159161 0.859047941279268 0.9078925462425311 1.0147766997207093 0.7799727632978323 0.5890097323446472 1.0 15.118470560165054 -5.270395097496324 18.853366198141835 0.8700537588107492 1.2495548456273613 0.6317310423386313 0.11588745063730713 13.107302680460927 27596.71205346123 0.03126135202784627 0.06750073644971477 5.365434562199245e-06 5.270395097496324 0.3795010868166121 SQRYS(ph)GAYGASVSDEELKR ddPTM_A459_Selumetinib_30min_R1 2 SQRYSGAYGASVSDEELKR 19 2 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 S(0.045)QRY(0.003)S(0.951)GAYGASVSDEELKR;S(0.056)QRY(0.257)S(0.673)GAY(0.014)GASVSDEELKR 79.021 0.008096800000000001 60222000.0 2968.1000000000004 2433.1 5062.7 4044.3999999999996 3561.0 3605.7 2240.34 3016.3999999999996 2063.02 2022.5 True False 3037.2509550827617 2148.2315208824975 4375.213147420493 3338.1214627906243 3238.908178745611 3569.4299317136592 2071.3493500919176 2936.395273351932 3500.794262980791 2282.1075758182897 1.3308973631506842 0.9413366589926031 1.91718094001405 1.4627362435329905 1.4192618319424508 1.56409363411967 0.9076475500280476 1.2867032669566578 1.5340180717491023 1.0 11.156151084808208 -7.228173915293988 24.986368416774948 1.2059838831177998 1.4385016131915582 0.17254249540579947 0.2738927717629887 1312.3750277698489 985752.8960585397 0.10698488291739217 0.08286536192997672 5.9132478792750434e-08 7.228173915293988 0.23251773007375842 SQS(ph)AAVTPSSTTSSTR ddPTM_A459_Selumetinib_30min_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 S(0.014)QS(0.896)AAVT(0.08)PS(0.006)S(0.004)T(0.001)TSSTR 194.39 1.2076e-06 9355400.0 3123.5 3649.7 3988.3 4681.5 3963.3 2974.9 3709.9 3516.7 1950.2 2720.7 True False 3196.271472727001 3222.391427300503 3446.710766163739 3863.9639076387875 3604.8202147774477 2944.9752069930837 3430.059256142374 3423.425692148502 3309.346963027571 3069.928346862214 1.0411550732100712 1.0496634003181613 1.1227332943085255 1.2586495419634665 1.1742359454291331 0.9592977015255599 1.1173092230795065 1.1151484026158458 1.0779883401546058 1.0 11.583989267673527 -6.698555105599449 24.99999368477077 1.0650975073998963 1.1316864671806075 0.20117230678181763 0.07332312058689609 134.45815368765486 53453.35594347197 0.026434510742861423 0.026434502648499534 2.0019115922564017e-07 6.698555105599449 0.06658895978071122 SQS(ph)CSDTAQER ddPTM_A459_Selumetinib_30min_R2 2 SQSCSDTAQER 11 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 S(0.004)QS(0.983)CS(0.013)DTAQER;S(0.04)QS(0.957)CS(0.003)DTAQER 148.85 0.00064154 7454900.0 10910.3 8022.799999999999 9234.2 8990.0 10143.4 6916.2 9957.4 15945.7 9137.9 12197.9 True False 10303.949203391361 8638.122962632093 8640.08162543677 7765.546491384988 8869.095408853455 7868.843770987385 10420.438830213789 15992.099347047259 10965.735334258701 11845.714933049683 0.8698461225538378 0.7292192165228988 0.7293845643145472 0.655557434504778 0.7487176129917305 0.6642776578248746 0.8796800268374383 1.3500324326081083 0.9257132554882079 1.0 13.53207765277845 -7.53081219444862 23.756350726380976 1.1056951770414138 0.7332434922274997 0.6598425134479056 0.1153203711550749 55.07503439439362 164914.58348920153 0.050498178298496205 0.029238034326646827 2.9456951897228985e-08 7.53081219444862 -0.3724516848139141 SQS(ph)DLSSSSSR ddPTM_A459_Selumetinib_30min_R2 2 SQSDLSSSSSR 11 0 J3KP75 J3KP75 PHACTR2 Phosphatase and actin regulator 1 S(0.32)QS(0.673)DLS(0.002)SS(0.005)SSR;SQS(0.996)DLS(0.004)SSSSR 195.87 2.0606e-05 14731400.0 50979.0 46828.0 54122.0 59666.0 59104.0 41755.0 45049.0 50960.0 41605.0 61091.0 True False 48145.791265106185 50419.55702424781 50639.84944357809 51539.387870408966 51678.82712353599 47506.37223584895 47143.867762900045 51108.28516311788 49927.16254082814 59327.14409651975 0.8115305733708917 0.8498564660759649 0.8535696469931497 0.8687319886249568 0.8710823335682457 0.8007527238890936 0.7946424605607402 0.861465454665565 0.8415568168864035 1.0 15.856404715238705 -9.398468084186888 1.5481007041011694 1.0000780528494517 0.8393181489815895 0.7705897769030776 0.026320409310582524 8.382539643930794 14.120143890982456 0.02866406658472096 0.007855355523293844 3.9951392005823417e-10 9.398468084186888 -0.1607599038678622 SQS(ph)FALR ddPTM_A459_Selumetinib_30min_R2 1 SQSFALR 7 0 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 S(0.012)QS(0.988)FALR 80.916 0.043999 10634000.0 62429.0 49227.0 52781.0 70062.0 61534.0 59226.0 49234.0 47406.0 50375.0 52680.0 True False 58959.44610308782 53002.55261024702 49385.12792360771 60519.43473630872 53803.548799060314 67383.84389990155 51523.47855532019 47543.94361151424 60451.407595101984 51158.99152092224 1.1524747527318921 1.0360359153790362 0.9653264549480206 1.1829677039579325 1.0516929126145214 1.3171456648504087 1.0071245938116056 0.9293369982101861 1.1816379838210742 1.0 15.642700204713009 SQS(ph)FHTAGSLPPTGR ddPTM_A459_Selumetinib_30min_R1 1 SQSFHTAGSLPPTGR 15 0 Q9ULD2;Q9ULD2-5;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 S(0.002)QS(0.946)FHT(0.037)AGS(0.015)LPPTGR 87.38799999999998 0.036054 0.0 570.81 865.61 573.6 861.22 1419.5 685.75 953.44 786.02 240.4 399.49 True False 584.1087623970864 764.2639787888286 495.7082705592658 710.8240941016071 1291.1064756330795 678.8519776111822 881.521253181052 765.1721962472109 407.9412418786932 450.7684328621255 1.2958067154088961 1.6954691657004086 1.0996960621483578 1.5769163106393114 2.8642344527882777 1.5059882816124783 1.9555966853843088 1.6974839861540407 0.9049907050688891 1.0 8.816242677450198 -5.997862804836901 24.997064725068086 1.744777343955156 1.3870830511812953 0.040875241378642735 0.5294190616809209 186.7266617894517 2183914.305778328 0.1498865078095917 0.2207050880147295 1.0049332020933732e-06 5.997862804836901 -0.35769429277386067 SQS(ph)FNNYDK ddPTM_A459_Selumetinib_30min_R1 2 SQSFNNYDK 9 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1 A0A0A0MTL4 NAV2 Neuron navigator 2 1 S(0.001)QS(0.999)FNNYDK;S(0.004)QS(0.996)FNNYDK 119.74 0.0039869 5466200.0 3450.1000000000004 3451.5 3937.5 4155.5 3805.9 3525.3999999999996 3208.5 3167.3 2160.7 2732.6 True False 3530.480617274027 3047.3967754411815 3402.809127139311 3429.819933395915 3461.6570169862202 3489.93767680709 2966.4802618218314 3083.292915159651 3666.55008871586 3083.355827778029 1.145012387304715 0.9883376897298419 1.1036057196134548 1.1123659171921003 1.1226913824865967 1.1318634214598766 0.9620946875792723 0.99997959605641 1.18914270473872 1.0 11.590285674706777 -7.2319060442457435 24.997976031225516 1.0378025003629376 1.0972104640705251 0.16456992031979878 0.06910436680649482 1410.2091942296283 1193648.7347760026 0.02654667718855987 0.020560890972595672 5.862649840181596e-08 7.2319060442457435 0.0594079637075875 SQS(ph)FNNYDK ddPTM_A459_Selumetinib_30min_R2 2 SQSFNNYDK 9 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1 A0A0A0MTL4 NAV2 Neuron navigator 2 1 S(0.003)QS(0.985)FNNY(0.012)DK;S(0.002)QS(0.998)FNNYDK 145.31 0.0018651 11518000.0 51686.0 44711.0 44970.0 48963.0 46957.0 42440.0 42016.0 38729.0 38915.0 48860.0 True False 48813.49903545146 48140.18993147575 42076.679159633895 42294.154934113845 41057.841859093794 48285.72476803806 43969.82725312453 38841.6949780689 46699.08737594824 47449.284846474206 1.0287509957924819 1.0145609167184926 0.886771619335807 0.8913549502581508 0.8652994874831008 1.0176280827892394 0.9266699676379164 0.8185938966992692 0.9841894883568154 1.0 15.534098722723751 -5.223491993326963 9.075767276790977 0.9175514886567304 1.0220402784761171 0.2965422500370244 0.05965999502999823 0.5056848902196037 115.00621523623575 0.014990573562294454 0.039432849769246804 5.977340644398142e-06 5.223491993326963 0.1044887898193867 SQS(ph)FNSIDK ddPTM_A459_Selumetinib_30min_R1 2 SQSFNSIDK 9 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.412)QS(0.577)FNS(0.011)IDK;S(0.005)QS(0.988)FNS(0.007)IDK 145.14 0.0018837 54101000.0 4151.4 5243.7 5314.1 5076.4 4825.7 4516.8 4558.3 4760.4 3257.6000000000004 3912.1 True False 4248.119542781774 4629.765166270007 4592.4744082618445 4189.902035829871 4389.216287046532 4471.365092926269 4214.463761091614 4634.138728041549 5527.909274309617 4414.256142080958 0.9623636250476248 1.0488211416040427 1.0403733404778979 0.9491751046994472 0.994327502929492 1.0129373894507148 0.9547392868563449 1.049811922752841 1.2522855712001486 1.0 12.107954630679346 -8.008652235802867 24.435773261734578 1.1344447912851023 0.9977999122075415 0.39326884259953077 0.06487914504001495 253.80525357836447 716795.2080957427 0.035447265109644174 0.015641077102484767 9.802746326480153e-09 8.008652235802867 -0.13664487907756084 SQS(ph)FNSIDK ddPTM_A459_Selumetinib_30min_R2 1 SQSFNSIDK 9 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;F8VZV4;H0YHX7;A0A1B0GTC4 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.155)QS(0.82)FNS(0.025)IDK 115.92 0.0080137 21617000.0 39221.0 43635.0 34724.0 46654.0 31122.0 38415.0 37697.0 37650.0 29318.0 42425.0 True False 37041.25383410289 46981.66419136103 32489.895644632594 40299.644717361014 27212.176125789894 43706.31755335021 39449.98519518842 37759.55526670698 35182.41921336377 41200.080016612126 0.8990578129743347 1.1403294404384101 0.7885881685553151 0.9781448167360828 0.6604884290228994 1.060830890030494 0.9575220528523717 0.9164922799053326 0.8539405554352807 1.0 15.330359518886521 -5.263915195189925 24.98736356493175 0.900767861909391 1.0196936184833763 0.13130774100657072 0.12105369898669498 397.3567185505162 4010398.042000389 0.030112175908632004 0.06760458331220752 5.446089884159122e-06 5.263915195189925 0.1189257565739853 SQS(ph)FSHQQPSR ddPTM_A459_Selumetinib_30min_R1 2 SQSFSHQQPSR 11 0 B3KNS5;Q8WVR3-2;Q8WVR3-3;Q8WVR3 B3KNS5 C7orf43 Uncharacterized protein C7orf43 1 S(0.01)QS(0.99)FSHQQPSR;S(0.005)QS(0.993)FS(0.002)HQQPSR 171.99 0.0002735 16185200.0 1512.28 2046.3 1903.1399999999999 2235.79 2461.17 1683.6399999999999 1977.2 2077.1800000000003 689.93 1408.69 True False 1547.5131816153623 1806.7182447009393 1644.7040411997243 1845.351247476177 2238.5576080548567 1666.7041102228088 1828.0582121471487 2022.0864387684542 1170.7608195065175 1589.5090833025802 0.9735793257626679 1.1366517270521386 1.0347245312889082 1.1609567173042032 1.408332693138013 1.0485653260690009 1.1500772353869952 1.2721452554187942 0.7365549727303135 1.0 10.634365545490379 -8.260280045702805 24.999867391023 0.8682774830461457 1.1498135560072862 0.42235060129792834 0.13090131270207384 95.5762954456818 2061131.2073473416 0.100270379285568 0.033008563647698254 5.491866281583895e-09 8.260280045702805 0.28153607296114047 SQS(ph)FSHQQPSR ddPTM_A459_Selumetinib_30min_R2 1 SQSFSHQQPSR 11 0 B3KNS5;Q8WVR3-2;Q8WVR3-3;Q8WVR3 B3KNS5 C7orf43 Uncharacterized protein C7orf43 1 S(0.005)QS(0.994)FS(0.001)HQQPSR 143.56 0.00082908 8125600.0 3959.4 2999.0 3939.9 6970.2 5133.0 2562.2 3341.6 3749.3 3562.1 3535.6 True False 3739.3523987340172 3229.0136566951237 3686.411123438776 6020.84673573433 4488.146650397775 2915.119792664163 3496.9910212547816 3760.2098422699696 4274.61953338983 3433.518041407985 1.0890731761527657 0.9404388204032852 1.073654216748221 1.7535503419884046 1.3071568566907306 0.8490183413944602 1.0184862811499218 1.0951478328996977 1.2449678381876026 1.0 11.745471828932573 -6.733671733223584 24.999348947592942 1.0460307329234968 1.2366257775362317 0.15649468191353266 0.2217935710981649 480.89675491418876 432952.4603034224 0.08126962524556554 0.08125272271382236 1.846410523754209e-07 6.733671733223584 0.1905950446127349 SQS(ph)FTHSPSGDPK ddPTM_A459_Selumetinib_30min_R1 1 SQSFTHSPSGDPK 13 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(0.003)QS(0.743)FT(0.204)HS(0.046)PS(0.004)GDPK 137.93 0.0010146 3553800.0 708.78 875.38 1120.0 1110.7 1114.8 814.0 762.99 827.47 457.78 713.46 True False 725.2931949541994 772.8901026468791 967.9101517196272 916.7370954212106 1013.966536833925 805.8118990528658 705.4370500132272 805.5228075986355 776.8192250716644 805.0395406889087 0.9009410821405534 0.9600647714589051 1.2023138029858045 1.138747911235164 1.2595238936540036 1.0009594042589463 0.8762762750877465 1.0006003020787193 0.9649454291486168 1.0 9.652915834809248 -6.986214461176613 24.996934688086053 0.957378687911332 1.0973192225582837 0.2697536134706824 0.10333114389419933 328.40144239399604 595478.804496092 0.03952700157664878 0.03484379174764643 1.0322515384764142e-07 6.986214461176613 0.13994053464695178 SQS(ph)GEDESMNQPGPIK ddPTM_A459_Selumetinib_30min_R2 2 SQSGEDESMNQPGPIK 16 0 A0A0C4DG33;O43933-2;O43933 A0A0C4DG33 PEX1 Peroxisome biogenesis factor 1 1 S(0.005)QS(0.995)GEDESMNQPGPIK;S(0.001)QS(0.874)GEDES(0.125)MNQPGPIK 203.93 3.0239e-07 46603000.0 152806.0 135431.0 162354.0 147483.0 164896.0 131849.0 142097.0 145435.0 115773.0 145577.0 True False 144313.65425088422 145818.1222206996 151908.32039766997 127395.56097763438 144180.29029105627 150010.00294394544 148704.79205986386 145858.19177193975 138930.83496789538 141373.8137555299 1.0207948022144895 1.031436574759559 1.0745152610819202 0.9011255875004733 1.0198514594815944 1.0610876155845215 1.051855277222775 1.0317200045558963 0.9827197221130426 1.0 17.10915539328537 -6.519271706599438 24.963293175151527 1.0303701243353043 1.0069091021250003 0.02970234287322493 0.04599462772976434 525.8733449683832 3639438.485434679 0.015549655344203337 0.015896377384074303 3.025020299880547e-07 6.519271706599438 -0.023461022210303994 SQS(ph)GGYSDR ddPTM_A459_Selumetinib_30min_R2 1 SQSGGYSDR 9 0 Q14011;F6WMK9;K7EMY9;K7EPM4;K7EQR7;D6W5Y5;Q14011-3;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 1 S(0.015)QS(0.985)GGYSDR 84.605 0.036275 2807800.0 26051.0 17567.0 20749.0 23940.0 21423.0 24062.0 35779.0 72403.0 25928.0 60233.0 True False 24603.18971041569 18914.332413192136 19414.031929803084 20679.33070119652 18731.65121595004 27376.32208691169 37442.7943947435 72613.68074303806 31114.324488849725 58493.9167858715 0.42061108337949926 0.3233555462259738 0.3318983066371153 0.35352959482773705 0.3202324659591687 0.46801998551623936 0.6401143307228035 1.2413885876176618 0.5319241076426774 1.0 15.835998975541353 -7.392247806656199 2.7663500865826753 0.9178891667273559 0.35718904972205856 0.676818020137425 0.1706457510361115 0.1488788622780407 2.2015935984017023 0.07668340716175116 0.04703462710221166 4.052772199356887e-08 7.392247806656199 -0.5607001170052973 SQS(ph)GTLDGESAAWSASGEDSR ddPTM_A459_Selumetinib_30min_R1 1 SQSGTLDGESAAWSASGEDSR 21 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 SQS(0.68)GT(0.204)LDGES(0.116)AAWSASGEDSR 244.33 1.4517999999999995e-31 11323000.0 1505.6 1832.8 2185.9 2299.2 1644.1 1745.7 2080.2 1696.9 815.86 1431.4 True False 1540.6775506123806 1618.214923954397 1889.066786289226 1897.6878813292956 1495.3914452894307 1728.1398429687808 1923.2888392213722 1651.892699691983 1384.4548319432233 1615.1341330167122 0.9539006817562184 1.0019074520652538 1.169603655617672 1.1749413516416967 0.9258620783998734 1.069966764767084 1.1907920214831293 1.0227588321761325 0.8571763816032845 1.0 10.657438266920241 -8.01078911974107 24.421728376626866 0.9323812835807019 1.0720269336781223 0.268359040020988 0.09202432861567733 502.2481408815994 1136856.798526953 0.05749522440893182 0.02468730446158893 9.754631781420272e-09 8.01078911974107 0.13964565009742036 SQS(ph)IEQESQEK ddPTM_A459_Selumetinib_30min_R1 3 SQSIEQESQEK 11 0 A0A0A0MRN0;Q5VTL8 A0A0A0MRN0 PRPF38B Pre-mRNA-splicing factor 38B 1 S(0.011)QS(0.803)IEQES(0.186)QEK;S(0.014)QS(0.907)IEQES(0.079)QEK;S(0.007)QS(0.986)IEQES(0.007)QEK 219.97 1.2682e-05 80493000.0 10538.2 11156.8 12917.6 12782.7 10569.5 10278.6 11504.7 10455.1 5765.7 9293.1 True False 10783.71955623233 9850.556669344402 11163.46087129772 10550.441405996864 9613.490591196785 10175.206616222089 10636.891216512886 10177.796785049 9783.971789933368 10485.959907459557 1.0283960315889584 0.9394043803597667 1.0646102950819218 1.006149317669185 0.916796428370653 0.9703648217254385 1.0143936568883845 0.9706118347647568 0.9330544724830766 1.0 13.356171314454954 -6.04543148448777 24.98791275518543 0.9679081583877648 1.0089497318039298 0.21728222868491343 0.039171589300841456 704.6587425414145 387570.2496321729 0.011592199567647078 0.014966315257106906 9.0067584468327e-07 6.04543148448777 0.04104157341616499 SQS(ph)IEQESQEK ddPTM_A459_Selumetinib_30min_R2 3 SQSIEQESQEK 11 0 A0A0A0MRN0;Q5VTL8 A0A0A0MRN0 PRPF38B Pre-mRNA-splicing factor 38B 1 SQS(0.997)IEQES(0.003)QEK;S(0.001)QS(0.999)IEQESQEK;S(0.007)QS(0.959)IEQES(0.034)QEK 172.58 0.00023979 168195000.0 482229.0 394643.0 504076.0 515679.0 521369.0 340250.0 399552.0 392131.0 283306.0 426369.0 True False 455428.64269563777 424910.8491227513 471644.2989564508 445442.63060410594 455869.9651220027 387116.3490180245 418131.9596972676 393272.0362892184 339975.1162310271 414058.6191302978 1.099913446198113 1.0262094048790673 1.1390761529058562 1.0757960588762243 1.1009792914817877 0.9349312660877253 1.0098375939511308 0.9497979709135382 0.821079674528022 1.0 18.659475501924597 -6.762581057007006 24.999701814824142 0.9441609241636653 1.087055828063117 0.6405830904299302 0.05439830543412428 20.38205792656507 446306.526154542 0.01866271774019629 0.017390846853368117 1.727503528025689e-07 6.762581057007006 0.1428949038994518 SQS(ph)KSPTGTPAR ddPTM_A459_Selumetinib_30min_R1 1 SQSKSPTGTPAR 12 1 Q13595 Q13595 TRA2A Transformer-2 protein homolog alpha 1 S(0.004)QS(0.908)KS(0.087)PTGTPAR 115.09 0.025355000000000003 2803400.0 441.42 728.72 1112.8 916.3 474.65 663.72 581.71 653.07 589.15 603.65 True False 451.7042271461988 643.4011236272631 961.6878721728581 756.2854060812604 431.71799130626385 657.0435794095431 537.8311463625923 635.748462129673 999.74452018649 681.1343575489307 0.6631646490006191 0.944602362950166 1.4118915915994934 1.1103321946682612 0.6338220741937107 0.9646313860512359 0.7896109488559402 0.9333671911917948 1.4677640455314593 1.0 9.411795595722174 -8.223540780078096 23.55476820979983 1.2338820848401633 0.9403051585310367 0.20803098005563103 0.23554414594343362 406.5501123494879 252679.96328227935 0.16559682191017805 0.06258503874005374 5.976669213689627e-09 8.223540780078096 -0.2935769263091266 SQS(ph)LNIR ddPTM_A459_Selumetinib_30min_R1 2 SQSLNIR 7 0 O00443;A0A0C4DGF9;O00443-2 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 S(0.088)QS(0.912)LNIR;S(0.003)QS(0.997)LNIR 109.44 0.015842 66969000.0 6913.6 8544.5 8575.7 9336.7 8601.7 6873.7 8129.4 7455.6 4089.8 5839.3 True False 7074.673428476191 7544.1059677697185 7411.167042948214 7706.220616565424 7823.677753753483 6804.55681882025 7516.192812982514 7257.853268798129 6940.091892826455 6588.831034598641 1.0737372671003915 1.1449839779097124 1.1248075726986169 1.1695884408173853 1.1874151443056489 1.032741131634551 1.1407475428515619 1.1015388360524625 1.053311559574575 1.0 12.68580681511827 -8.47639011014857 0.7966426675146325 0.9984858589665915 1.1318991387260222 0.4766259052600478 0.04224305337720765 0.588158122754885 0.841410680195216 0.041113875543330416 0.015305021328290756 3.3389498016998862e-09 8.47639011014857 0.13341327975943074 SQS(ph)LNIR ddPTM_A459_Selumetinib_30min_R2 1 SQSLNIR 7 0 O00443;A0A0C4DGF9;O00443-2 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 S(0.224)QS(0.776)LNIR 96.665 0.022999 52933000.0 197270.0 155500.0 246370.0 188770.0 239840.0 175030.0 160490.0 209620.0 146700.0 201680.0 True False 186306.52313437907 167426.34998869334 230518.8224273743 163059.20035358664 209709.15500319566 199138.79373585543 167953.10300490176 210229.95949554082 176044.09914047585 195856.97437243018 0.9512376249625375 0.8548398673326035 1.17697530642454 0.8325422205467281 1.0707260013341418 1.0167562037243807 0.857529345294245 1.0733851075212661 0.8988400832013298 1.0 17.579440977315038 SQS(ph)LPGADSLLAKPIDK ddPTM_A459_Selumetinib_30min_R2 1 SQSLPGADSLLAKPIDK 17 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 S(0.006)QS(0.994)LPGADSLLAKPIDK 104.42 0.0015335999999999998 4030200.0 33880.0 24055.0 34716.0 41990.0 46584.0 16166.0 28097.0 29310.0 17400.0 28529.0 True False 31997.085232385827 25899.94115098408 32482.41035592288 36270.88956320974 40731.70145375608 18392.719759663127 29403.56617314927 29395.2872474683 20880.486196620823 27705.293642756093 1.154908720512763 0.9348372727951921 1.1724261354080912 1.309168205574794 1.4701775761328526 0.6638702334949675 1.0612977632466716 1.0609989421698145 0.7536641360262318 1.0 14.757874037502452 -6.763455910421275 24.999999967512405 0.9213619125729628 1.196721385323406 0.429023287299115 0.17263653757475717 61.959552780669206 768136.4442459125 0.06261401093473927 0.05798552371394205 1.7240271053864211e-07 6.763455910421275 0.27535947275044315 SQS(ph)LPHSATVTLGGTSDPSTLSSSALSER ddPTM_A459_Selumetinib_30min_R1 2 SQSLPHSATVTLGGTSDPSTLSSSALSER 29 0 F8WDP1;A0A0A0MRY0;Q8WUA7-3;Q8WUA7-4;Q8WUA7 F8WDP1 TBC1D22A TBC1 domain family member 22A 1 S(0.243)QS(0.728)LPHS(0.028)AT(0.001)VTLGGTSDPSTLSSSALSER;S(0.164)QS(0.776)LPHS(0.043)AT(0.017)VTLGGTSDPSTLSSSALSER 153.07 3.0249e-16 21957000.0 4444.0 4627.5 5010.0 5979.8 6451.5 5003.5 4786.1 4217.3 1421.94 3562.1 True False 4547.536553481282 4085.7101487336167 4329.669517960117 4935.54018474814 5867.962964104836 4953.169332814513 4425.0806236887865 4105.443504278977 2412.928325611435 4019.3302327922534 1.1314165022768186 1.0165151684725464 1.077211691300187 1.2279509019888097 1.459935517671641 1.2323369929654961 1.1009497521716836 1.0214247813688353 0.600330947162597 1.0 11.972739400411411 -7.93817058245411 2.864931126948994 0.7997662312651809 1.1849174849935635 0.5091172292212633 0.14629887207999634 0.22321195598242105 3.588307725867449 0.10993645168087066 0.042444367204768414 1.153000292703786e-08 7.93817058245411 0.38515125372838266 SQS(ph)LPHSATVTLGGTSDPSTLSSSALSER ddPTM_A459_Selumetinib_30min_R2 2 SQSLPHSATVTLGGTSDPSTLSSSALSER 29 0 F8WDP1;A0A0A0MRY0;Q8WUA7-3;Q8WUA7-4;Q8WUA7 F8WDP1 TBC1D22A TBC1 domain family member 22A 1 S(0.058)QS(0.937)LPHS(0.003)AT(0.001)VTLGGTSDPSTLSSSALSER;S(0.133)QS(0.592)LPHS(0.133)AT(0.133)VT(0.01)LGGTSDPSTLSSSALSER 219.42 1.7773e-46 17223300.0 38562.0 33225.0 46761.0 52214.0 62018.0 27862.0 31053.0 42604.0 32891.0 36063.0 True False 36418.87841591684 35773.25066478676 43752.448169527284 45102.363125826036 54226.744392045446 31699.73759394617 32497.02603035217 42727.97058652809 39470.119051325055 35021.76748707327 1.0398926447489907 1.0214576028463116 1.249292977165603 1.2878380036779573 1.548372577485155 0.9051438539087645 0.9279093650069775 1.2200403820937713 1.1270167636711566 1.0 15.095964275442244 SQS(ph)LPNSLDYTQTSDPGR ddPTM_A459_Selumetinib_30min_R1 3 SQSLPNSLDYTQTSDPGR 18 0 H0YLG5;Q96TC7;H0YNE5 H0YLG5;H0YNE5 RMDN3 Regulator of microtubule dynamics protein 3 1 S(0.003)QS(0.794)LPNS(0.203)LDYTQTSDPGR;SQS(0.985)LPNS(0.015)LDYTQTSDPGR;S(0.002)QS(0.997)LPNSLDYTQTSDPGR 311.87 1.3969999999999993e-111 34052000.0 4125.52 3833.7999999999997 4360.0 4108.0 4529.52 3717.02 4116.799999999999 4370.4 2454.25 3461.8900000000003 True False 4221.636589135485 3384.9369137147346 3767.935947765689 3390.6149167104836 4119.825715751708 3679.630153584131 3806.2664615453027 4254.482794940089 4164.6829986721405 3906.2573031641946 1.0807369462620455 0.8665422298149245 0.9645897992212492 0.8679957958642346 1.054673411404445 0.9419835581756255 0.9744023924031077 1.0891455592271968 1.0661568543625155 1.0 11.931571266598777 -7.6666787332016435 5.8653510856419375 1.057688294830933 0.9584923939744696 0.2577654600425945 0.06754258591275852 0.2474606751851543 12.470626271749984 0.031186569970230726 0.01760924251615738 2.154374831568371e-08 7.6666787332016435 -0.09919590085646335 SQS(ph)LPNSLDYTQTSDPGR ddPTM_A459_Selumetinib_30min_R2 3 SQSLPNSLDYTQTSDPGR 18 0 H0YLG5;Q96TC7;H0YNE5 H0YLG5;H0YNE5 RMDN3 Regulator of microtubule dynamics protein 3 1 S(0.004)QS(0.74)LPNS(0.252)LDYT(0.003)QTSDPGR;S(0.003)QS(0.989)LPNS(0.007)LDYTQTS(0.002)DPGR;SQS(0.481)LPNS(0.283)LDYT(0.202)QT(0.013)S(0.019)DPGR 170.22 8.5524e-08 36264000.0 80752.0 53042.0 83154.0 85511.0 69366.0 58052.0 82343.0 77977.0 69774.0 58693.0 True False 76264.12711586847 57110.1508430886 77803.96217122977 73864.2542852973 60651.62294009197 66048.13605641254 86172.11265955918 78203.90016021264 83730.74964844964 56998.38058727205 1.3380051561131288 1.0019609373926934 1.3650205737354524 1.2959009277851565 1.0640937920547817 1.1587721506452997 1.5118344025163715 1.372037229030957 1.4690022556035045 1.0 15.798633310196992 -7.237286810224752 24.8885166251663 1.36922160056855 1.199919848221781 0.12255967083931463 0.16777809152174564 1205.0297487842797 1241749.7669755288 0.06134000490514796 0.047490750870525636 5.79046165175397e-08 7.237286810224752 -0.16930175234676903 SQS(ph)LPTTLLSPVR ddPTM_A459_Selumetinib_30min_R1 1 SQSLPTTLLSPVR 13 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 S(0.024)QS(0.908)LPT(0.034)T(0.034)LLS(0.001)PVR 125.36 0.0021367 78222000.0 2161.9 1799.0 1935.6 2073.5 1693.8 1707.3 2334.4 1343.2 573.59 1194.5 True False 2212.2680636748855 1588.3722436675903 1672.7561514897411 1711.402149415577 1540.5960890646784 1690.1261121043694 2158.314328563779 1307.5739726715012 973.3403366439256 1347.825710415303 1.6413606348206724 1.1784700584010732 1.2410774913726181 1.269750336553712 1.1430232241155107 1.253964885106394 1.6013304330711582 0.9701357991372644 0.7221559353872334 1.0 10.396418235947202 -7.940757398908848 8.079965663121417 0.8559206082402011 1.309894628696622 0.5824706559464352 0.16975424649574689 0.1668117064233061 20.03272361573625 0.09184658746033209 0.04382528176028696 1.1461530147946682e-08 7.940757398908848 0.4539740204564209 SQS(ph)LPTTLLSPVR ddPTM_A459_Selumetinib_30min_R2 1 SQSLPTTLLSPVR 13 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 S(0.001)QS(0.68)LPT(0.159)T(0.159)LLSPVR 157.37 0.00036494 51926000.0 26147.0 26653.0 28847.0 28462.0 27617.0 17960.0 19363.0 20967.0 19373.0 22940.0 True False 24693.854414734134 28697.199397097414 26991.015426238828 24585.426500311423 24147.50556088748 20433.826975352586 20263.41786705662 21028.010498726293 23248.14132684686 22277.66259472204 1.1084580489420166 1.2881602490871855 1.2115730414479597 1.10359093534957 1.0839335346881696 0.9172338834233763 0.9095845572172987 0.94390560092728 1.0435628615883044 1.0 14.44331025047232 -6.289795746424183 1.64871655593625 0.9578504988852243 1.2077582031687168 0.7399141396596944 0.06038496565035861 0.17931846998575762 0.9667054332783364 0.022167883273627245 0.02914919690487725 5.131026451937176e-07 6.289795746424183 0.24990770428349252 SQS(ph)LQDQPTR ddPTM_A459_Selumetinib_30min_R1 1 SQSLQDQPTR 10 0 Q8N4C8;Q8N4C8-2;Q8N4C8-3 Q8N4C8 MINK1 Misshapen-like kinase 1 1 S(0.006)QS(0.994)LQDQPTR 146.79 0.0017574 0.0 3253.8 3564.9 2934.1 2883.7 3335.0 2768.4 3408.6 2816.7 1524.5 2673.6 True False 3329.607209207335 3147.5198507229516 2535.665335857638 2380.1159287531696 3033.3498388420708 2740.5524095060864 3151.486557720396 2741.991966068953 2586.9651549254068 3016.782603069362 1.10369477927236 1.0433366486271083 0.8405197422173474 0.7889583844495691 1.005491690304715 0.9084354990372091 1.0446515285900888 0.9089126817687065 0.8575245535735169 1.0 11.558795020664695 -5.077922113201342 5.2827445098045125 0.9189362634726674 1.0909163601078526 0.4090234854185665 0.07561922471504165 0.19417581985309754 9.372824443562774 0.02009877210582049 0.05821342098958981 8.357528895353401e-06 5.077922113201342 0.1719800966351852 SQS(ph)LQDQPTR ddPTM_A459_Selumetinib_30min_R2 3 SQSLQDQPTR 10 0 Q8N4C8;Q8N4C8-2;Q8N4C8-3 Q8N4C8 MINK1 Misshapen-like kinase 1 1 S(0.006)QS(0.99)LQDQPT(0.004)R;S(0.001)QS(0.999)LQDQPTR;S(0.006)QS(0.952)LQDQPT(0.042)R 124.47 0.0038317 14776900.0 68777.0 61788.0 68334.0 66801.0 73825.0 56633.0 70746.0 61351.0 53032.0 68050.0 True False 64954.6496761453 66526.94092026622 63937.46483643369 57702.58856184753 64550.443496126245 64433.68168681197 74035.82918053956 61529.52125279516 63639.8818378848 66085.21968486652 0.9828922410470534 1.00668411541198 0.9675002238219893 0.8731542217307843 0.976775802576446 0.9750089656063783 1.120308437099646 0.9310632777829048 0.9629972048418309 1.0 16.012040020847856 -7.01330223328273 24.826545066920495 1.004963380614069 0.9610071438145749 0.11315014882529117 0.05579049393179391 1369.9859657493366 2556863.079166533 0.021695357849737463 0.017614428320349228 9.698348069895867e-08 7.01330223328273 -0.04395623679949412 SQS(ph)MDAMGLSNK ddPTM_A459_Selumetinib_30min_R1 1 SQSMDAMGLSNK 12 0 P47736-4;F2Z357;J3KPC5;P47736;P47736-3;A0A0A0MQY8;X6R8W7;P47736-2 P47736-4 RAP1GAP Rap1 GTPase-activating protein 1 1 S(0.119)QS(0.88)MDAMGLSNK 115.1 0.0054695 0.0 1235.5 1311.1 1122.8 1348.0 1177.4 1124.9 1306.8 1405.8 783.06 1266.1 True False 1264.2847461354916 1157.5958024861459 970.3299270989255 1112.597105093898 1070.9043778868531 1113.5845273274801 1208.2270238892843 1368.513617318044 1328.7956275604392 1428.616267858362 0.8849715452497122 0.8102916287111144 0.6792096302763979 0.7787935291831668 0.7496095361508415 0.7794847030524538 0.8457323712969731 0.9579294651107271 0.9301277449069204 1.0 10.480402739373034 -7.608602160847708 2.208764378234984 0.9648353973535974 0.7751969849759044 0.7194218580541015 0.05079963610061472 0.17630370245982152 1.7173591952104357 0.03245003795327635 0.015807709229078593 2.4626224774484102e-08 7.608602160847708 -0.18963841237769297 SQS(ph)MDIDGVSCEK ddPTM_A459_Selumetinib_30min_R1 4 SQSMDIDGVSCEK 13 0 O95155-2;O95155;O95155-4 O95155-2 UBE4B Ubiquitin conjugation factor E4 B 1 S(0.002)QS(0.998)MDIDGVSCEK;SQS(1)MDIDGVSCEK;S(0.005)QS(0.747)MDIDGVS(0.248)CEK;S(0.232)QS(0.758)MDIDGVS(0.01)CEK 168.45 0.00027951 37862700.0 12702.0 13181.2 15085.000000000002 18999.6 13558.9 13525.9 13564.2 13219.9 5804.870000000001 11067.64 True False 12997.93188621046 11637.938976226364 13036.53985597372 15681.67652666322 12332.499889018223 13389.841726534583 12541.041473399935 12869.265307712898 9850.440419069757 12488.279401942924 1.0408104645855571 0.9319089204887373 1.0439020009390163 1.25571153734945 0.9875259426930771 1.0721926772755737 1.0042249272104533 1.0305074777323369 0.7887748265415352 1.0 13.608287099947818 -8.11956746336928 7.4357040923056745 0.8952730043748235 1.0477182829438718 0.30245719404758675 0.09229885266272303 0.3203583145759073 18.102147818699994 0.06338096467676872 0.023725365075078733 7.593334585336678e-09 8.11956746336928 0.15244527856904833 SQS(ph)MDIDGVSCEK ddPTM_A459_Selumetinib_30min_R2 2 SQSMDIDGVSCEK 13 0 O95155-2;O95155;O95155-4 O95155-2 UBE4B Ubiquitin conjugation factor E4 B 1 SQS(0.895)MDIDGVS(0.105)CEK;S(0.024)QS(0.976)MDIDGVSCEK 193.32 0.00010459 40139000.0 191420.0 208630.0 211245.0 216270.0 213030.0 109672.0 140672.0 165952.0 135172.0 164417.0 True False 180781.6427149735 224631.25014881702 197653.72668616517 186813.6529134404 186267.2668876363 124778.32249670743 147213.52673627977 166434.89284516734 162210.17702124332 159669.85400333072 1.1322215069552353 1.4068482216068865 1.237890069606014 1.169999522324004 1.1665775487196899 0.7814770250501046 0.921986981545113 1.0423689173141946 1.0159098474397028 1.0 17.284732429106562 -6.588726522179186 6.685306070431939 0.9533533353136802 1.2394585880477778 0.6767389662210828 0.09437465891649752 0.130468382781124 10.497037645580116 0.032917515522673566 0.03294995478717518 2.577943992674207e-07 6.588726522179186 0.2861052527340976 SQS(ph)PAASDCSSSSSSASLPSSGR ddPTM_A459_Selumetinib_30min_R1 8 SQSPAASDCSSSSSSASLPSSGR 23 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 S(0.002)QS(0.555)PAAS(0.423)DCS(0.004)S(0.015)S(0.001)SSSASLPSSGR;S(0.247)QS(0.753)PAASDCSSSSSSASLPSSGR;S(0.006)QS(0.768)PAAS(0.224)DCSSS(0.001)S(0.001)SSASLPSSGR;S(0.006)QS(0.993)PAAS(0.001)DCSSSSSSASLPSSGR;S(0.004)QS(0.995)PAAS(0.001)DCSSSSSSASLPSSGR;S(0.021)QS(0.957)PAAS(0.022)DCSSSSSSASLPSSGR;S(0.005)QS(0.994)PAAS(0.001)DCSSSSSSASLPSSGR;S(0.013)QS(0.986)PAAS(0.001)DCSSSSSSASLPSSGR 293.56 3.4839999999999973e-118 913881600.0 14668.150000000001 16978.48 18667.800000000003 20006.179999999997 17123.675000000003 14835.339999999998 15690.719999999998 15294.41 9596.65 12755.539999999999 True False 15009.889355748524 14990.631668518796 16132.81529488541 16512.476225509967 15574.841619680366 14686.109949010985 14507.15635772886 14888.752563554746 16284.814138415819 14392.8378084812 1.0428721253916804 1.0415341205113378 1.1208918984259588 1.1472703608026305 1.0821244445972047 1.0203762554982014 1.0079427386571602 1.0344556620224903 1.131452626306936 1.0 13.813063453113699 -6.6657863330178735 6.496245645246586 1.039228888606718 1.090324633006752 0.22191845773800067 0.04497975296291635 0.35704294506814344 20.469502767785276 0.015963664736278815 0.015908042320938728 2.1588062512582356e-07 6.6657863330178735 0.05109574440003395 SQS(ph)PAASDCSSSSSSASLPSSGR ddPTM_A459_Selumetinib_30min_R2 5 SQSPAASDCSSSSSSASLPSSGR 23 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 S(0.233)QS(0.752)PAAS(0.015)DCSSSSSSASLPSSGR;S(0.004)QS(0.91)PAAS(0.086)DCSSSSSSASLPSSGR;S(0.017)QS(0.98)PAAS(0.003)DCSSSSSSASLPSSGR;S(0.127)QS(0.863)PAAS(0.01)DCSSSSSSASLPSSGR;S(0.025)QS(0.493)PAAS(0.444)DCS(0.007)S(0.021)S(0.003)S(0.007)S(0.001)SASLPSSGR 327.32 2.8063999999999988e-145 882839700.0 156643.2 159396.40000000002 181312.1 190263.5 196107.4 129190.27 130460.93999999999 139765.8 110620.75 153332.5 True False 147937.5980364128 171621.59133979265 169646.67688368823 164349.2830771552 171470.63518960014 146985.0570199936 136527.63221344826 140172.49533852612 132747.9910020028 148905.3923193208 0.9935006095626637 1.1525545762087515 1.139291695494067 1.10371612818907 1.1515408039884092 0.987103655083161 0.9168750042353806 0.9413527150039848 0.8914921678412479 1.0 17.184036473699216 -6.910349783396902 4.367979934192342 0.9345153862783283 1.1115833978984961 0.7269673234436942 0.04985447372303492 0.10698712291343904 3.7288980321831398 0.017670606938197993 0.01543261697257656 1.2292783038366836e-07 6.910349783396902 0.17706801162016783 SQS(ph)PHYFR ddPTM_A459_Selumetinib_30min_R1 1 SQSPHYFR 8 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 S(0.001)QS(0.999)PHYFR 106.4 0.0090913 30488000.0 2711.7 3207.0 3363.1 4040.2 4262.6 2940.9 4139.0 3252.4 1337.3 2417.1 True False 2774.8773339503127 2831.52294910615 2906.4094921859623 3334.6549139468602 3877.0485826231525 2911.3172161235543 3826.7918976719834 3166.1357867158945 2269.3004274724476 2727.358329547783 1.0174230880804023 1.0381924950710963 1.0656500323768852 1.2226684252742732 1.421539861711533 1.0674494746740055 1.403112988936256 1.160880018006605 0.8320507074142748 1.0 11.413288543514497 -8.219983284451324 9.00149070183251 0.9163168512845283 1.1805271167992568 0.3517058476231645 0.14025912225372514 0.4184319058749789 88.47377016104225 0.10065516554539389 0.03749686161760688 6.025827784204412e-09 8.219983284451324 0.2642102655147285 SQS(ph)PHYFR ddPTM_A459_Selumetinib_30min_R2 1 SQSPHYFR 8 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 S(0.079)QS(0.914)PHY(0.006)FR 93.442 0.024057 21848000.0 38696.0 33789.0 45209.0 55164.0 55739.0 46339.0 37809.0 37183.0 40388.0 45009.0 True False 36545.43123236135 36380.50765124091 42300.302159837454 47650.568036792174 48736.56850701766 52721.77662644002 39567.1934171122 37291.19637402297 48466.728535006994 43709.473222573855 0.8360986426504765 0.832325465603006 0.9677605114213861 1.090165690035883 1.1150115733229096 1.2061865023624156 0.9052315322042735 0.8531605078865111 1.1088380838681955 1.0 15.415658370719019 -5.393296163238986 3.277454706829383 1.0379173775858972 0.832333387368503 0.40740626967903304 0.0978436678228979 0.26992871995037715 5.346896950557221 0.02930497723981115 0.06952613220808147 4.0430008883667465e-06 5.393296163238986 -0.20558399021739415 SQS(ph)PVHLR ddPTM_A459_Selumetinib_30min_R1 3 SQSPVHLR 8 0 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 S(0.007)QS(0.993)PVHLR;S(0.008)QS(0.992)PVHLR;S(0.022)QS(0.978)PVHLR 93.561 0.02389 91007000.0 11859.900000000001 13109.400000000001 14033.099999999999 14660.400000000001 13591.6 11246.199999999999 12718.7 11494.100000000002 5796.2 9750.0 True False 12136.21259465181 11574.545353605288 12127.482098300612 12100.236349791234 12362.242179791885 11133.073438732597 11759.31821911588 11189.239129901352 9835.72806230151 11001.507473042444 1.1031408763198853 1.0520872145900904 1.102347303587004 1.099870756752296 1.1236862048299943 1.0119589034514167 1.0688824461493425 1.0170641757339998 0.8940345753890998 1.0 13.425413601015205 -7.9402196303259105 2.757468373731677 0.946763804831643 1.080789271477224 0.6542392511165723 0.03861532242931939 0.16235469277676975 2.4066387584726976 0.027436126249538888 0.01044283241918735 1.1475731268967724e-08 7.9402196303259105 0.13402546664558102 SQS(ph)PVHLR ddPTM_A459_Selumetinib_30min_R2 3 SQSPVHLR 8 0 Q96T58;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 1 S(0.002)QS(0.998)PVHLR;S(0.011)QS(0.989)PVHLR;S(0.001)QS(0.999)PVHLR 106.49 0.009065299999999998 219920000.0 385939.0 314315.0 394377.0 447848.0 463189.0 287282.0 286745.0 358305.0 324063.0 406557.0 True False 364490.0554162271 338421.9498179828 369003.2131852108 386850.3298191084 404999.0568578015 326852.48781365505 300079.21067443857 359347.6082294145 388884.6550767553 394818.64304805646 0.9231834966107773 0.8571579781676896 0.934614460797629 0.9798177888272156 1.025785038242244 0.827854746904318 0.7600431640152149 0.910158662861509 0.9849703450538964 1.0 18.59083058884601 -6.781577412848319 24.999938302634014 0.8824551900202413 0.9407370813450717 0.07192313654793214 0.0769097507908249 591.4500435645117 734238.0217965655 0.02893637150898933 0.02555102492488742 1.6535700101908338e-07 6.781577412848319 0.058281891324830415 SQS(ph)SDLLER ddPTM_A459_Selumetinib_30min_R2 1 SQSSDLLER 9 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 S(0.034)QS(0.946)S(0.02)DLLER 108.59 0.011919 13055000.0 55571.0 44521.0 56756.0 56477.0 49016.0 33024.0 44404.0 51827.0 39778.0 45762.0 True False 52482.58628833863 47935.617542421984 53104.38075126048 48784.73517174085 42858.17187140025 37572.75623797569 46468.87398485679 51977.8079895783 47734.711490182985 44440.73215604489 1.1809568326655004 1.07864148984102 1.1949483767457947 1.0977482324198182 0.9643894191687078 0.845457633462166 1.0456370030469004 1.169598372211071 1.0741207260621164 1.0 15.439594964710164 -6.041058816537316 6.019880598648099 1.0185201613659625 1.1448889857459568 0.354725941500464 0.08252256752177753 0.2646298023981635 26.02881289740633 0.027436344982623158 0.03659193099361764 9.097900513472084e-07 6.041058816537316 0.1263688243799943 SQS(ph)SDTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R1 2 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.005)QS(0.824)S(0.144)DT(0.027)EQQS(0.928)PT(0.055)S(0.017)GGGK;S(0.003)QS(0.648)S(0.293)DT(0.057)EQQS(0.888)PT(0.09)S(0.021)GGGK 208.52 8.413e-08 17585000.0 7239.62 8658.5 8893.3 8556.31 7896.5 7028.349999999999 7610.959999999999 7254.55 4809.91 6040.25 True False 7408.289060151698 7644.758794772555 7685.638707400137 7062.111080330838 7182.262969240307 6957.651180231212 7036.859159580952 7062.135767900564 8162.065968072985 6815.5749245173965 1.086964657009661 1.1216601503817922 1.1276581642075263 1.0361724665261307 1.0538014839223377 1.0208458211210811 1.032467434884699 1.0361760887546294 1.1975608893553367 1.0 12.73461964466625 -5.760094920848088 24.99958912717853 1.053098472139839 1.1130509136141982 0.21042564756072346 0.05166821991034441 55.7269371926591 1036180.4262507813 0.01415709091618312 0.022917601077812936 1.7374210507179642e-06 5.760094920848088 0.059952441474359075 SQS(ph)SDTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R2 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.002)QS(0.966)S(0.033)DT(0.255)EQQS(0.719)PT(0.023)S(0.002)GGGK 174.65 3.8805e-06 9224900.0 13603.0 11776.0 11675.0 11918.0 13977.0 9340.9 12720.0 13942.0 11869.0 13407.0 True False 12846.999717123517 12679.181334191984 10923.843210778876 10294.747840303262 12221.08430403462 10627.524186752282 13311.505204201838 13982.568911777644 14243.131647568545 13019.905074430619 0.9867199218182731 0.9738305511222374 0.839010971918057 0.7906930028638068 0.9386461909031291 0.8162520483826984 1.0223964866183153 1.0739378537588242 1.0939504985746926 1.0 13.6684313096853 -7.417715876362846 5.3187565357072994 1.0604447323537378 0.8903616302222981 0.5878663872501031 0.06462280648932489 0.1659710672733139 6.8661023997522195 0.029500348872865127 0.019466333311831237 3.8219422773658614e-08 7.417715876362846 -0.17008310213143973 SQS(ph)SDTEQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R1 5 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.111)QS(0.514)S(0.265)DT(0.111)EQQSPTSGGGK;S(0.133)QS(0.51)S(0.268)DT(0.089)EQQSPTSGGGK;S(0.163)QS(0.539)S(0.228)DT(0.069)EQQSPTSGGGK;S(0.208)QS(0.479)S(0.093)DT(0.208)EQQS(0.011)PTSGGGK;SQS(0.556)S(0.444)DTEQQSPTSGGGK 211.11 2.7166e-29 61338200.0 26936.079999999998 31431.83 32391.670000000002 35108.54 31157.5 25869.78 29201.3 27243.799999999996 15814.78 22981.020000000004 True False 27563.63825551216 27751.776731338676 27993.059128707202 28977.492557917896 28339.309626303402 25609.55350108089 26998.6224308985 26521.205923665733 26836.526594169394 25930.857771091076 1.0629666977789445 1.0702220873802966 1.0795269240925445 1.1174907060044637 1.0928797603408777 0.9876091923820433 1.0411773752042177 1.0227662408157128 1.0349262963482835 1.0 14.662382309675532 -6.747335922508762 24.999970676815146 1.0202113074554278 1.0853610270697394 0.7389071489272978 0.019969005326514938 129.47008108433613 229499.75587896138 0.0068716255060014666 0.006841295583052814 1.7892213735348796e-07 6.747335922508762 0.0651497196143116 SQS(ph)SDTEQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R2 3 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.012)QS(0.494)S(0.494)DTEQQSPTSGGGK;SQS(0.974)S(0.026)DTEQQSPTSGGGK;SQS(0.49)S(0.49)DT(0.019)EQQSPTSGGGK 303.05 2.2319999999999998e-89 176946600.0 113035.1 104397.0 118619.9 119566.0 124370.2 91053.3 96894.7 117658.5 85984.0 118977.3 True False 106753.06165735703 112403.9142107373 110988.02477758189 103280.90453714538 108745.70359230507 103595.06557543819 101400.49554320556 118000.8667555869 103183.20259369224 115542.11620885025 0.9239320272132943 0.9728393238666286 0.9605850093394817 0.8938810186794408 0.9411780497056139 0.8966000361996403 0.877606355763099 1.0212801238839377 0.8930354227473346 1.0 16.81805929811579 -10.74229316862283 4.206523035249541 1.0000351087145112 0.9325524123402028 0.19246463058261887 0.042188734077294794 1.3674140007621702e-05 2.5374555791861573e-06 0.040211088050749674 0.009747548604578733 1.8101177678865893e-11 10.74229316862283 -0.06748269637430837 SQS(ph)SHSYDDSTLPLIDR ddPTM_A459_Selumetinib_30min_R2 2 SQSSHSYDDSTLPLIDR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 S(0.01)QS(0.771)S(0.077)HS(0.142)YDDSTLPLIDR;SQS(0.904)S(0.096)HSYDDSTLPLIDR 229.96 2.2467e-16 9728800.0 13717.4 12491.1 20692.7 28864.5 33408.5 14683.3 15622.0 18404.5 17925.5 18889.5 True False 12955.041823103003 13449.127204783084 19361.35421050827 24933.10530596019 29211.425554220557 16705.79129327364 16348.45395440574 18458.054047971 21511.10088031762 18344.11105418491 0.7062234732899484 0.7331577510110465 1.055453390645021 1.359188528259161 1.5924143431063915 0.9106896073583509 0.8912099314115365 1.0062114208450617 1.1726434067466145 1.0 14.163029373599375 -5.300893061965195 4.001580815848785 1.137338672873769 0.7111698678124347 0.3943097349293182 0.20174266816926878 0.23016868037768068 8.07979909086705 0.06001550433460128 0.14554078689793198 5.00157675603147e-06 5.300893061965195 -0.42616880506133437 SQS(ph)SSNCSNPISVPLRR ddPTM_A459_Selumetinib_30min_R1 1 SQSSSNCSNPISVPLRR 17 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.334)QS(0.449)S(0.15)S(0.051)NCS(0.006)NPIS(0.01)VPLRR 92.427 0.03576 0.0 686.3 750.73 858.35 754.18 738.67 624.61 745.78 625.71 454.23 625.18 True False 702.289454692665 662.8341825950913 741.7907845790547 622.4766207119552 671.8574289227803 618.3269905005045 689.5252141690777 609.1141382074782 770.7951343534065 705.4279427688899 0.9955509444892331 0.939619970245844 1.0515472092974318 0.882409928742912 0.9524111368280348 0.876527499142572 0.9774566222350194 0.8634675510820163 1.0926631731200531 1.0 9.462354913392131 -8.273129246556636 24.99620902181284 1.0463315852997834 0.9432314970507426 0.3335184697943907 0.05877286748828588 960.7092185673861 2054243.4030628926 0.0523864627300568 0.013980323806632155 5.331761980010382e-09 8.273129246556636 -0.10310008824904082 SQS(ph)SSQFR ddPTM_A459_Selumetinib_30min_R2 2 SQSSSQFR 8 0 Q16537-2;Q16537 Q16537-2 PPP2R5E Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1 S(0.007)QS(0.471)S(0.471)S(0.051)QFR;SQS(0.474)S(0.474)S(0.052)QFR 99.788 0.018368 299810000.0 683620.0 525910.0 499460.0 543660.0 590340.0 539970.0 473670.0 667620.0 516180.0 654570.0 True False 645627.1371476869 566245.6059328222 467325.2873709307 469612.57013418933 516176.2114934393 614345.9661403745 495696.5935592987 669562.6636695592 619430.4232742384 635670.8633228956 1.01566262416488 0.8907842699802836 0.73516864518226 0.7387668638441979 0.81201804467675 0.9664529264861258 0.7798007147411199 1.0533165861488414 0.9744514952852138 1.0 19.277920436860626 -7.766050111909681 24.999806808330117 1.0104130575731467 0.8445828054383427 0.4104279074739767 0.08827416243766864 122.53190766149918 664361.3439346396 0.049201559501489384 0.0248800375045972 1.7137595506354097e-08 7.766050111909681 -0.16583025213480396 SQS(ph)TTFNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R1 1 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.002)QS(0.48)T(0.48)T(0.037)FNPDDMSEPEFK 308.73 5.136399999999998e-103 34832000.0 6417.9 7989.1 6850.6 7960.7 6635.1 7252.6 7187.6 6188.9 3279.1 5644.7 True False 6567.42458294049 7053.73245796817 5920.326147652208 6570.513185846436 6034.956376522053 7179.645428833926 6645.433545230039 6024.750267619605 5564.393204011744 6369.252229034119 1.031113912085787 1.1074663405248515 0.9295166739769718 1.0315988360289567 0.9475141130401171 1.1272352186188583 1.0433616547539053 0.9459117100365239 0.8736336706288 1.0 12.636908289986778 -7.8219248407584185 5.542155972834878 0.9295033339159972 1.0306220063035019 0.2984405447461165 0.06382301393110165 0.23984316080933357 14.489268732351304 0.03529461765324641 0.01680945242661902 1.506867822995852e-08 7.8219248407584185 0.10111867238750472 SQS(ph)TTFNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R2 1 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.035)QS(0.447)T(0.447)T(0.071)FNPDDMSEPEFK 134.21 0.0049427 0.0 13474.0 17758.0 13043.0 16032.0 14749.0 9380.4 10232.0 11776.0 9516.1 10462.0 True False 12725.169020695597 19119.981499030346 12203.827580144656 13848.41394325741 12896.09876226706 10672.464953206976 10707.808274323363 11810.266210378248 11419.585902049628 10159.93487645954 1.2524852939933382 1.881900005415501 1.201171831171949 1.3630416052512342 1.2693091952928934 1.050446197045511 1.0539248926814717 1.162435227586203 1.1239821948572413 1.0 13.310603534247129 -6.012700235339676 0.992530651789594 1.0846795282574322 1.5439954226356318 0.4751368092345394 0.17404852447974214 0.47978335765301805 0.9618428676123748 0.07092258713042539 0.1501659138941022 9.71180077110737e-07 6.012700235339676 0.45931589437819964 SQS(ph)TTFNPDDMSEPEFKR ddPTM_A459_Selumetinib_30min_R1 4 SQSTTFNPDDMSEPEFKR 18 1 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.207)QS(0.576)T(0.207)T(0.009)FNPDDMSEPEFKR;S(0.016)QS(0.867)T(0.116)T(0.002)FNPDDMSEPEFKR;S(0.041)QS(0.71)T(0.124)T(0.124)FNPDDMSEPEFKR;S(0.008)QS(0.329)T(0.329)T(0.329)FNPDDMS(0.004)EPEFKR 219.21 1.3294999999999999e-14 89479800.0 9098.5 8936.7 12194.9 12941.100000000002 9716.5 9521.0 9532.0 7878.999999999999 4888.68 6665.3 True False 9310.477347400863 7890.387009440883 10538.899561790779 10681.179819533114 8837.644290587403 9425.227384376329 8812.99356574277 7670.023325401098 8295.732904939807 7520.856180519977 1.2379544461329077 1.0491341437798054 1.4012898676467098 1.4202079607902618 1.1750848677944519 1.2532120224275698 1.1718072190463635 1.0198337983469865 1.1030303872086884 1.0 12.876681193517006 -7.545388733195544 2.341356991585805 1.0426478019890542 1.2584787699264692 0.46661142883845963 0.10237271870838953 0.3018634392019767 3.304512638463779 0.0621636634073647 0.03252552923753745 2.8484674877277584e-08 7.545388733195544 0.21583096793741507 SQS(ph)TTFNPDDMSEPEFKR ddPTM_A459_Selumetinib_30min_R2 5 SQSTTFNPDDMSEPEFKR 18 1 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.062)QS(0.87)T(0.062)T(0.005)FNPDDMSEPEFKR;S(0.157)QS(0.618)T(0.171)T(0.054)FNPDDMSEPEFKR;S(0.224)QS(0.625)T(0.139)T(0.012)FNPDDMSEPEFKR;S(0.156)QS(0.399)T(0.399)T(0.045)FNPDDMSEPEFKR;S(0.075)QS(0.408)T(0.11)T(0.408)FNPDDMSEPEFKR 123.17 0.0004587 74957700.0 180398.0 197380.0 182258.0 193184.0 186654.0 125300.0 128140.0 142815.0 114418.0 156699.0 True False 170372.2013504117 212518.41132326916 170531.7187075064 166872.00593901216 163204.85581206818 142558.9376398483 134098.76390459313 143230.5680057039 137304.79710603223 152174.69271710358 1.1195830154698436 1.3965424048422166 1.120631267017105 1.0965818491858645 1.07248355753522 0.936811076102311 0.8812159335447843 0.9412246244648116 0.9022840437817421 1.0 17.215368927054193 -6.13446474456017 1.034015652083855 0.9217554275423263 1.2542875905551976 0.7072547822704536 0.0783962913684299 0.2709364691358252 0.6002336531231165 0.03263215837650894 0.058114261263174156 7.33728275071783e-07 6.13446474456017 0.33253216301287125 SQS(ph)WDDRGER ddPTM_A459_Selumetinib_30min_R1 1 SQSWDDRGER 10 1 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 SQS(1)WDDRGER 142.76 0.0055243 5230200.0 2629.4 2634.0 2971.3 3314.1 3693.4 2387.5 2607.3 2822.4 1550.3 2161.1 True False 2690.659904078238 2325.610055486621 2567.813780182614 2735.354648361787 3359.332622122731 2363.4839176765554 2410.629261850728 2747.540783552742 2630.7458705679633 2438.4982358966163 1.103408591595271 0.9537058593079166 1.053030813138337 1.121737390700231 1.377623560546695 0.9692374933408641 0.9885712551948429 1.126734784182648 1.0788385375233454 1.0 11.251777213335181 -10.29508580614851 0.5875411554075533 0.9835019160895654 1.08737496121821 0.04909030836398509 0.11400738425071048 70.30306875839574 16.23020125607579 2.34392507436653 0.04999776645174916 5.068905489944523e-11 10.29508580614851 0.10387304512864459 SQS(ph)WEER ddPTM_A459_Selumetinib_30min_R1 1 SQSWEER 7 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 SQS(1)WEER 97.597 0.022241 0.0 3635.8 3341.1 3373.4 3680.4 3774.9 3101.0 3094.2 3311.8 1902.2 3011.7 True False 3720.507065964729 2949.9224587647486 2915.31080875981 3037.687229664379 3433.460961512727 3069.806755482721 2860.802002845287 3223.9603057575027 3227.8944688088604 3398.2810314422477 1.0948203022472591 0.8680631270547942 0.8578780806490678 0.8938893521631933 1.0103522721472946 0.9033410501014036 0.8418379693662793 0.9487032637760502 0.9498609558606533 1.0 11.730589450281022 -8.541377185450573 2.039317367766616 0.9987460216772234 0.9208285449638194 0.08066552379151992 0.07278117725375723 0.8605725839316051 8.220134931495739 0.06942464986384479 0.01934891888733986 2.874900474510318e-09 8.541377185450573 -0.07791747671340399 SQS(ph)WEER ddPTM_A459_Selumetinib_30min_R2 2 SQSWEER 7 0 Q6Y7W6;I1E4Y6;Q6Y7W6-3;Q6Y7W6-5;Q6Y7W6-4;E7ESB6 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 S(0.08)QS(0.92)WEER;SQS(1)WEER 107.45 0.016687999999999998 377190000.0 377120.0 277941.0 355250.0 430770.0 516340.0 216104.0 305480.0 349470.0 274210.0 244810.0 True False 356161.1801309729 299258.1809788259 332393.6017669546 372098.3828803023 451472.7530618325 245870.36440320683 319685.4252971365 350486.89984212676 329059.662067551 237741.69920723146 1.4981014324311661 1.2587534369306101 1.3981291581382123 1.5651372229654867 1.8990053262313855 1.034191163027273 1.344675445507258 1.4742340153656388 1.3841057886135522 1.0 17.85903544445378 -6.788868608848605 24.99986017544916 1.2831582589146373 1.50441173374608 0.30128213263733117 0.20584558280303952 368.85132839356527 336180.04195872386 0.07618675028281863 0.06720585645906417 1.6260406225445844e-07 6.788868608848605 0.22125347483144275 SQSAAVT(ph)PSSTTSSTR ddPTM_A459_Selumetinib_30min_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 S(0.001)QS(0.22)AAVT(0.748)PS(0.019)S(0.002)T(0.002)T(0.007)SSTR 193.31 2.6980000000000003e-06 8877700.0 2071.0 2105.8 2311.8 3013.4 2373.0 2067.6 2375.4 2700.7 1241.9 2241.7 True False 2119.2502705354946 1859.2519570401394 1997.8702578084212 2487.1662585237023 2158.3625689871774 2046.8018212305963 2196.2216655544876 2629.0686628900553 2107.413595212767 2529.4440310071022 0.8378324424485137 0.7350437227503608 0.7898456076978173 0.9832857450233572 0.8532952469115602 0.809190397628865 0.8682626057869556 1.0393859799472565 0.8331528863177483 1.0 11.304604601655926 -1.5228787452803378 0.10089606667881039 1.0688817568314113 0.22004714999839645 0.3345031874161979 0.07704371948379105 144.7642725499274 1.0377585954987165 0.9829520495876948 17.01360719497079 0.02999999999999998 1.5228787452803378 -0.8488346068330148 SQSAAVT(ph)PSSTTSSTR ddPTM_A459_Selumetinib_30min_R2 3 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 S(0.001)QS(0.087)AAVT(0.816)PS(0.088)S(0.006)TTSSTR;SQSAAVT(0.493)PS(0.039)S(0.089)T(0.018)T(0.018)S(0.089)S(0.128)T(0.128)R;S(0.055)QS(0.022)AAVT(0.352)PS(0.182)S(0.182)T(0.182)T(0.017)S(0.005)S(0.001)T(0.001)R 220.1 2.0311000000000004e-10 49317000.0 40493.6 38778.4 40189.3 48008.8 48802.3 41954.2 39919.8 44323.8 38695.4 43069.4 True False 38243.12782072431 41752.57858779131 37603.56419280132 41469.91862020063 42671.31877590246 47733.010227691404 41776.14979958307 44452.77491979989 46435.56123981159 41825.87451425985 0.9143413799437938 0.9982475936888408 0.899050279988312 0.9914895767705261 1.020213427010459 1.1412316127763835 0.9988111494319186 1.0628056301523223 1.1102113650721193 1.0 15.352108084647414 -6.221900596242653 2.515834873439964 1.0628531455689685 0.9442817880944434 0.5448610623461829 0.048738071879777745 0.216561059954728 2.7026292288381057 0.015205962292290959 0.01981187337668692 5.999283755140961e-07 6.221900596242653 -0.11857135747452507 SQSAAVTPS(ph)STTSSTR ddPTM_A459_Selumetinib_30min_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 SQSAAVT(0.224)PS(0.597)S(0.176)T(0.002)TSSTR 220.78 7.679300000000001e-11 21803000.0 1794.5 1985.0 2382.5 2328.0 2080.1 2104.3 1943.9 2017.4 1248.3 1668.0 True False 1836.308358510838 1752.5952771985367 2058.969586135724 1921.45850197225 1891.9553222714826 2083.132652551531 1797.2700579571322 1963.8919985612602 2118.273927775262 1882.1040476958751 0.9756678228065544 0.9311893672106563 1.0939722427441632 1.0209098186280157 1.005234181706196 1.1068105693209473 0.9549259830546568 1.043455594798551 1.1254818405860785 1.0 10.878130670935532 -5.249415009890529 24.890422547095426 1.0422752448823556 0.9534285873852989 0.3344092126061312 0.05098715577711433 812.6756173014262 1682227.7894310437 0.012620115333286445 0.032869372988023865 5.630993034337194e-06 5.249415009890529 -0.08884665749705667 SQSAAVTPSS(ph)TTSSTR ddPTM_A459_Selumetinib_30min_R2 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 SQSAAVT(0.169)PS(0.165)S(0.461)T(0.165)T(0.022)S(0.008)S(0.008)T(0.003)R 80.541 0.022973 14032000.0 4468.8 7210.8 5722.4 7535.4 5854.4 4895.0 4590.7 6084.7 5848.3 7451.7 True False 4220.441986023784 7763.8451736236075 5354.227014078036 6509.065520709947 5118.917932999945 5569.241817614188 4804.176646299479 6102.405469623689 7018.123415155036 7236.55005915825 0.5832118829444956 1.0728655381576524 0.7398866822322286 0.8994708068760429 0.7073699333457487 0.7695990177758817 0.6638766549012579 0.8432755138480332 0.9698161911107375 1.0 12.821086357831165 -8.209372379594546 3.442657254157292 0.9928809973505274 0.7867875153531168 0.29328600487048495 0.12679428355906344 0.3073385950369117 6.958577203866189 0.10241447886129561 0.031670528974778206 6.174867179283602e-09 8.209372379594546 -0.20609348199741062 SQSAAVTPSSTTS(ph)STR ddPTM_A459_Selumetinib_30min_R2 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 S(0.001)QS(0.184)AAVT(0.009)PS(0.019)S(0.048)T(0.048)T(0.128)S(0.413)S(0.075)T(0.075)R 89.50200000000002 0.013104 3315700.0 9875.4 9227.2 13080.0 12003.0 12834.0 6991.3 8435.9 9950.8 8593.8 11406.0 True False 9326.564802358422 9934.89656987571 12238.44704042721 10368.17069367008 11221.678182584272 7954.288114297464 8828.186065418733 9979.755180556382 10312.800130834485 11076.679143652986 0.8420000869757619 0.8969201365346466 1.1048841337468844 0.9360360229998278 1.0130904792899387 0.7181112688323491 0.797006571277037 0.9009699614053415 0.9310371815494711 1.0 13.435237796938841 -6.715638828136725 24.999998512594043 0.8587081361462501 0.9620351553988918 0.17158565297704698 0.09638074648602592 209.10112954018305 114136.05278449309 0.032753493723536066 0.032753371372504184 1.9246916928582783e-07 6.715638828136725 0.10332701925264176 SQSASVESIPEVLEECTSPADHSDS(ph)ASVHDMDYVNPR ddPTM_A459_Selumetinib_30min_R1 1 SQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPR 37 0 A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 A0A669KB10 GBF1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 1 SQSASVESIPEVLEECT(0.039)S(0.039)PADHS(0.19)DS(0.411)AS(0.315)VHDMDY(0.007)VNPR 55.925 0.00021376 5300800.0 667.21 784.83 851.84 1225.4 1027.1 932.22 967.88 824.81 388.81 578.02 True False 682.7546948353391 692.9417387424314 736.1648068221849 1011.406893606871 934.1989863492336 922.8427131880371 894.8720323553413 802.9333594395332 659.7821724411596 652.2144973915887 1.0468253888343333 1.0624445508551617 1.1287157978952322 1.5507274027974016 1.4323493115921062 1.4149374429405908 1.3720517344128604 1.231087874695697 1.0116030463594974 1.0 9.349202699371524 -8.208609917358578 3.5597740759547203 0.9970121963587395 1.2931832818232718 0.3299071259906283 0.15755161659055852 0.3095999576840368 7.559656814466594 0.15057779268462898 0.0469901379623023 6.185717508969193e-09 8.208609917358578 0.2961710854645323 SQSDLDDQHDYDSVAS(ph)DEDTDQEPLR ddPTM_A459_Selumetinib_30min_R2 2 SQSDLDDQHDYDSVASDEDTDQEPLR 26 0 J3QRU8;Q9Y2X7;Q9Y2X7-3;A0A0C4DGN6;J3QLH1 J3QRU8 GIT1 ARF GTPase-activating protein GIT1 1 SQSDLDDQHDY(0.015)DS(0.213)VAS(0.623)DEDT(0.149)DQEPLR;SQSDLDDQHDYDS(0.241)VAS(0.735)DEDT(0.024)DQEPLR 123.62 5.078199999999999e-09 48103000.0 221862.0 215819.0 246720.0 236076.0 237135.0 152870.0 160306.0 180780.0 161283.0 193409.0 True False 209531.7982239548 232371.62333253952 230846.30380842465 203922.04154618486 207343.98128620224 173926.45488430676 167760.54664031282 181306.03987025993 193544.10662354005 187824.77963306903 1.1155705793095683 1.2371723464097568 1.2290513757524522 1.0857036113369234 1.1039223987977813 0.9260037744970936 0.8931757937799617 0.9652935050660302 1.0304503324941692 1.0 17.519027884049564 -6.3818411890441915 1.6785857049986357 0.9579594695464534 1.1905934440487485 0.7453749550913373 0.05638380904472822 0.1796339938369096 1.0084068956838712 0.021595321689685105 0.026341789464495866 4.1510580900768974e-07 6.3818411890441915 0.23263397450229506 SQSESS(ph)DEVTELDLSHGKK ddPTM_A459_Selumetinib_30min_R2 2 SQSESSDEVTELDLSHGKK 19 1 Q86YS7-3;Q86YS7;Q86YS7-2;Q86YS7-4;Q86YS7-5 Q86YS7-3 C2CD5 C2 domain-containing protein 5 1 S(0.045)QS(0.029)ES(0.275)S(0.651)DEVTELDLSHGKK;S(0.233)QS(0.233)ES(0.233)S(0.302)DEVTELDLSHGKK 89.631 0.0014739 11477600.0 45899.1 51165.8 49970.2 51998.5 52801.2 30076.6 34597.2 35913.0 23223.5 45750.4 True False 43348.21177065528 55090.05233602247 46755.17173544003 44916.21459758427 46167.841207282865 34219.37864180899 36206.03835305121 36017.50088428279 27868.84891880597 44429.4670781853 0.9756635544237507 1.239944027216826 1.0523459949038336 1.010955511092276 1.0391266032076965 0.7701955682158199 0.8149104802300958 0.8106669571548214 0.6272604816475386 1.0 15.439229216187254 -6.714153241847212 4.964654563226363 0.7927744917750297 1.0735022849322837 0.594683841839498 0.1067186626004951 0.1306198739056148 7.031625002147809 0.03531725424731615 0.034455283833503825 1.9312867376285692e-07 6.714153241847212 0.28072779315725405 SQSFNTDTTTSGISSMS(ph)SSPSR ddPTM_A459_Selumetinib_30min_R2 1 SQSFNTDTTTSGISSMSSSPSR 22 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 SQSFNTDTTTSGISSMS(0.497)S(0.497)S(0.006)PSR 274.68 6.862399999999998e-66 18284000.0 70743.0 58280.0 86817.0 74515.0 94477.0 63923.0 78394.0 79656.0 72996.0 62404.0 True False 66811.38726666686 62749.888600264 81231.28873920251 64365.92845445522 82607.95462490377 72727.8130147809 82039.4763347641 79887.78577223925 87597.23967865149 60602.23437493609 1.1024574911432434 1.0354385320521473 1.3404008874761588 1.0621048731674443 1.363117308741818 1.2000846794662032 1.3537368247381658 1.3182316889173857 1.4454457097522466 1.0 15.887083365693455 -5.26023686563231 0.7434700249973332 1.2946445821350863 1.0076478631007986 0.18038726408396544 0.13875476053219704 2.381601444828401 1.5583297691445421 0.05808771440570774 0.5116950200914149 5.4924123418548315e-06 5.26023686563231 -0.2869967190342877 SQSFNTDTTTSGISSMSS(ph)SPSR ddPTM_A459_Selumetinib_30min_R2 2 SQSFNTDTTTSGISSMSSSPSR 22 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 SQSFNTDTTTSGISSMS(0.227)S(0.769)S(0.004)PSR;SQSFNTDTTTSGISSMS(0.034)S(0.855)S(0.11)PS(0.001)R 274.68 6.862399999999998e-66 25412500.0 119650.0 92776.0 120996.0 138183.0 155685.0 102565.0 124520.0 131208.0 120267.0 105482.0 True False 113000.33199689993 99891.6208781419 113211.24909048388 119362.23702102918 136126.458458441 116692.39775763015 130310.4267316991 131589.79355734642 144323.76054074673 102436.46058485055 1.1031260876423885 0.9751568953849133 1.1051850917545938 1.165231952954472 1.3288867819255061 1.139168584031377 1.272109813124204 1.2845991828109629 1.4089100669502335 1.0 16.6443697849165 -5.807962440861881 2.3418734844075835 1.2498423294223484 1.0409389001975728 0.34669175758377657 0.10895655965290586 0.2900053808616942 3.2441353788229548 0.03137129514486423 0.05618625340677431 1.5561002021732992e-06 5.807962440861881 -0.20890342922477556 SQSFT(ph)HSPSGDPK ddPTM_A459_Selumetinib_30min_R1 1 SQSFTHSPSGDPK 13 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 S(0.01)QS(0.304)FT(0.494)HS(0.148)PS(0.045)GDPK 137.73 0.0026861 0.0 913.59 1110.9 1073.5 1356.8 1326.3 1341.9 1237.9 850.0 420.78 829.31 True False 934.8748694633138 980.8353115566016 927.7245963134098 1119.8603502903568 1206.3363991772837 1328.4017043477163 1144.5242063609924 827.4552388108815 714.0329274447442 935.7600166634694 0.9990540873895086 1.048169716690666 0.9914129475432061 1.1967388329791142 1.2891514679998586 1.4195965639611785 1.2230958643027827 0.8842600924126277 0.7630513323177542 1.0 9.86999477603474 -7.76999341728173 23.36445398784918 0.8677413983513335 1.1710279998841884 0.47766975622076935 0.13592923573889595 80.22017209223452 219104.17265936124 0.08258468980167888 0.04078066715073195 1.698269393392623e-08 7.76999341728173 0.3032866015328549 SQSFT(ph)HSPSGDPK ddPTM_A459_Selumetinib_30min_R2 1 SQSFTHSPSGDPK 13 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 SQS(0.001)FT(0.69)HS(0.155)PS(0.155)GDPK 117.02 0.008646 6003800.0 20126.0 14220.0 23427.0 20061.0 22465.0 18014.0 17579.0 16719.0 13931.0 17226.0 True False 19007.47749076144 15310.628275493387 21919.732325389014 17328.657192844756 19642.745860351835 20495.26498518938 18396.458332127673 16767.649522020554 16717.589264662336 16728.640621476967 1.1362236729718973 0.9152344546057691 1.3103116279064237 1.0358676227760826 1.1741985678820557 1.2251602176734346 1.0996983406116985 1.002331863145742 0.9993393750834456 1.0 14.03003259549747 -7.701469541477128 4.241953327392317 0.99930519179647 1.1307342297536942 0.26127751902025576 0.09934588034369003 0.2981315882490214 10.71978295735409 0.0507984635737187 0.026942110250279684 1.9885222672161004e-08 7.701469541477128 0.13142903795722416 SQSFTHS(ph)PSGDPK ddPTM_A459_Selumetinib_30min_R2 1 SQSFTHSPSGDPK 13 0 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 SQS(0.004)FT(0.113)HS(0.873)PS(0.01)GDPK 216.27 2.0894e-08 6116600.0 27108.0 22798.0 26423.0 28707.0 27399.0 24395.0 23151.0 22828.0 20003.0 26519.0 True False 25601.44588192194 24546.53329287611 24722.972947187176 24797.057077662845 23956.892669832203 27755.18981423866 24227.56737283622 22894.425700621166 24004.158930517617 25753.327565363288 0.9941024443130363 0.9531402584996338 0.9599913985654468 0.9628680804345233 0.9302445522439133 1.077732178251317 0.9407548329956736 0.8889890303501138 0.9320798980090557 1.0 14.652471233277918 -7.502637121274773 24.97358803798993 0.9292950469296611 0.9774569995262341 0.13966791586221128 0.045057636319481814 1224.6888877686326 1510995.2918635698 0.018809296626686376 0.01250030546436103 3.143133871222644e-08 7.502637121274773 0.048161952596572966 SQSGEDES(ph)MNQPGPIK ddPTM_A459_Selumetinib_30min_R1 2 SQSGEDESMNQPGPIK 16 0 A0A0C4DG33;O43933-2;O43933 A0A0C4DG33 PEX1 Peroxisome biogenesis factor 1 1 S(0.001)QS(0.181)GEDES(0.817)MNQPGPIK;S(0.001)QS(0.438)GEDES(0.561)MNQPGPIK 197.73 1.0279e-06 15418700.0 4904.4 4843.0 4516.200000000001 5537.5 5219.8 4440.5 4996.5 4896.9 2677.2 4332.2 True False 5018.662977698832 4275.979308550383 3902.924845710874 4570.479576748858 4747.670011630538 4395.832601651413 4619.60998229477 4767.018304627062 4543.012865048412 4888.280069201483 1.0266725528512215 0.8747410639359867 0.7984249655213455 0.9349872576952125 0.9712352697512454 0.8992595635727327 0.945037910450454 0.9751933680440227 0.929368366937807 1.0 12.255111229980946 -7.9513258856738345 0.4955024755114575 0.9942547982888916 0.9047647546829649 0.13932149064586608 0.05812098378683801 1.700030329879822 1.026808050567227 0.06420789568453238 0.04048490273546579 1.1185981953157143e-08 7.9513258856738345 -0.08949004360592672 SQSGT(ph)LDGESAAWSASGEDSR ddPTM_A459_Selumetinib_30min_R1 1 SQSGTLDGESAAWSASGEDSR 21 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 SQS(0.317)GT(0.683)LDGESAAWSASGEDSR 215.32 2.0772e-18 9809200.0 846.43 871.07 903.4 973.19 734.13 890.92 776.32 822.38 357.64 666.28 True False 866.1501721339245 769.0847194505435 780.7232420209918 803.2406355388213 667.7280711211782 881.9581536906377 717.7615573811825 800.5678109332857 606.8889590078866 751.8035281167919 1.1520964450693145 1.0229863131622163 1.0384671165040174 1.068418284163783 0.8881683127954773 1.1731231907089779 0.9547195916719334 1.0648630672679131 0.8072440954461803 1.0 9.554211875552909 -1.5228787452820036 0.26275088716520745 0.9640025414731092 1.9837097724022628 0.20252109568105203 0.09485329338177673 91.45022191059313 1.266409932853457 0.10993009228848435 41.90153535361471 0.029999999999884914 1.5228787452820036 1.0197072309291535 SQSGT(ph)LDGESAAWSASGEDSR ddPTM_A459_Selumetinib_30min_R2 1 SQSGTLDGESAAWSASGEDSR 21 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 S(0.005)QS(0.26)GT(0.735)LDGESAAWSASGEDSR 297.3 5.590399999999997e-101 8108800.0 35681.0 28000.0 33896.0 36639.0 41724.0 28733.0 27740.0 33064.0 21270.0 28197.0 True False 33697.992862360064 30147.50996580975 31715.168263174364 31648.70499419963 36482.25810270734 32690.70993779543 29029.964965767194 33160.21076596014 25524.594333455454 27382.879345395686 1.2306226981212711 1.1009620129987874 1.1582115913791635 1.1557844080235933 1.3323017511247106 1.19383756271388 1.0601501982167723 1.2109833428286236 0.932136975498426 1.0 14.740986535382499 -8.261339468245241 24.999999921279876 0.966068467215091 1.1776602768701145 0.5903504996989001 0.07137358441968185 6.393746025614795 1600945.1089023082 0.05792565057844077 0.018661203829584902 5.478485692029794e-09 8.261339468245241 0.21159180965502355 SQSGTLDGES(ph)AAWSASGEDSR ddPTM_A459_Selumetinib_30min_R2 1 SQSGTLDGESAAWSASGEDSR 21 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4 P49815 TSC2 Tuberin 1 SQSGT(0.495)LDGES(0.504)AAWSASGEDSR 203.93 4.5966999999999996e-17 9709200.0 21494.0 18382.0 21808.0 25750.0 30839.0 20035.0 22945.0 21638.0 17906.0 20659.0 True False 20299.449527299334 19791.84029255412 20404.897022755107 22242.805578772357 26964.729115842012 22794.639390378 24011.98796465496 21700.96299763627 21487.700335442103 20062.520991471778 1.0118095096786826 0.9865081412733365 1.017065454108627 1.1086745074673008 1.344034935953674 1.136180213845887 1.196857960914385 1.0816668058246999 1.0710369023203088 1.0 14.292215281281033 -5.8111421188550345 4.125874588327333 1.151191706542509 1.001335265615936 0.3153033324366449 0.08631711386463205 0.23225696991444006 8.188008712581949 0.025153859373375678 0.04015588413169385 1.5447488520347368e-06 5.8111421188550345 -0.14985644092657302 SQSIEQES(ph)QEK ddPTM_A459_Selumetinib_30min_R1 1 SQSIEQESQEK 11 0 A0A0A0MRN0;Q5VTL8 A0A0A0MRN0 PRPF38B Pre-mRNA-splicing factor 38B 1 SQS(0.102)IEQES(0.898)QEK 151.16 0.00060076 76039000.0 3715.1 3828.6 4504.5 4593.1 3724.9 3668.3 3795.1 3898.0 2274.7 3213.8 True False 3801.654601673787 3380.3457321321494 3892.8136414473756 3791.0013081652714 3387.9834526845066 3631.4002325499105 3508.83255154746 3794.612377511545 3859.9997624852876 3626.322535062956 1.0483498268329812 0.932169077473817 1.0734879768161034 1.0454120590515694 0.9342752664513578 1.001400233277062 0.967600790503469 1.0464078528099452 1.0644391736153924 1.0 11.824291532701086 -7.788743050740803 24.94367525064938 1.0415676756080496 0.999801158627299 0.11057595322363023 0.04695598309512558 451.3161031427884 412299.9603680629 0.02546691042536962 0.01223812442453343 1.626510792228222e-08 7.788743050740803 -0.04176651698075062 SQSLPHS(ph)ATVTLGGTSDPSTLSSSALSER ddPTM_A459_Selumetinib_30min_R2 1 SQSLPHSATVTLGGTSDPSTLSSSALSER 29 0 F8WDP1;A0A0A0MRY0;Q8WUA7-3;Q8WUA7-4;Q8WUA7 F8WDP1 TBC1D22A TBC1 domain family member 22A 1 S(0.004)QS(0.016)LPHS(0.75)AT(0.171)VT(0.06)LGGTSDPSTLSSSALSER 101.71 3.7796e-08 14724000.0 41285.0 37512.0 50928.0 58790.0 66653.0 33513.0 36769.0 46646.0 38683.0 36465.0 True False 38990.544976949524 40389.04977990911 47651.347926213864 50782.70058159331 58279.45425461967 38129.11154927568 38478.831356391296 46781.73213733897 46420.68089332667 35412.16070255184 1.1010495887120444 1.140541807633857 1.3456210234237431 1.4340469368177766 1.6457469157034517 1.0767236675995333 1.086599365669841 1.3210640415389234 1.3108683563039842 1.0 15.11195725320638 SQSLPNS(ph)LDYTQTSDPGR ddPTM_A459_Selumetinib_30min_R2 1 SQSLPNSLDYTQTSDPGR 18 0 H0YLG5;Q96TC7;H0YNE5 H0YLG5;H0YNE5 RMDN3 Regulator of microtubule dynamics protein 3 1 SQSLPNS(0.99)LDYT(0.009)QTSDPGR 276.3 3.1615999999999994e-55 12041000.0 57283.0 37707.0 54029.0 66465.0 50917.0 43087.0 58201.0 54972.0 52366.0 36829.0 True False 54099.440182017635 40599.00565288531 50552.83296232738 57412.35234147984 44520.35125624459 49021.84314515681 60907.461823093625 55131.95941889549 62840.66322829004 35765.65107676625 1.5126088454506346 1.1351395663326498 1.413446461629411 1.605237165073601 1.2447795556884322 1.3706403118438386 1.7029596830870994 1.5414778637906525 1.7570115833599913 1.0 15.126287084088323 -7.208852822803347 24.1593132352462 1.5454855676081178 1.374734350032163 0.04851086154541551 0.2269498082030717 497.7830938437521 228691.2141779755 0.08234159904816844 0.06378141682264489 6.182258739840783e-08 7.208852822803347 -0.1707512175759549 SQSLPT(ph)TLLSPVR ddPTM_A459_Selumetinib_30min_R1 1 SQSLPTTLLSPVR 13 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 S(0.022)QS(0.005)LPT(0.486)T(0.486)LLSPVR 120.21 0.0072029 84304000.0 1794.3 2130.3 2185.2 2819.5 2071.9 1890.2 2023.1 2004.6 822.04 1196.0 True False 1836.10369889997 1880.8834856503984 1888.4618424444 2327.127253569915 1884.4970108236553 1871.186304164282 1870.495938192845 1951.4314961415207 1394.941840573881 1349.5182500265394 1.3605623331613792 1.3937443866456858 1.3993599882085788 1.724413325662065 1.3964220274802472 1.3865587250320504 1.386047160278166 1.4460208271382355 1.0336591154261519 1.0 10.398228771688974 -8.273852598695587 5.93590181924282 1.00929236065798 1.4394546367647842 0.7400210978563608 0.09954543652619349 0.08406682459526234 12.245987144704355 0.08933003257192246 0.02642759353360008 5.322888896146228e-09 8.273852598695587 0.43016227610680424 SQSLPT(ph)TLLSPVR ddPTM_A459_Selumetinib_30min_R2 1 SQSLPTTLLSPVR 13 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 S(0.025)QS(0.134)LPT(0.42)T(0.42)LLSPVR 167.61 0.00070497 36089000.0 31816.0 26188.0 34023.0 35953.0 28220.0 20154.0 21214.0 23465.0 22807.0 27191.0 True False 30047.794089539184 28196.535392308084 31833.997221441514 31056.139377615647 24674.751309999065 22930.03056020357 22200.493034743533 23533.27926516012 27369.03728082365 26405.925179297603 1.1379186256687883 1.0678109250424723 1.205562653279028 1.1761049524583156 0.934439946430819 0.8683668685913284 0.8407390721590338 0.8912120709790674 1.036473332973053 1.0 14.68857406927168 -6.2915983900339585 7.026750284348297 0.9150560998254078 1.145471908100904 0.7334224299930561 0.06418212876636291 0.10738821900485024 19.535216929191144 0.020636856682526367 0.023837248435573513 5.109773032868516e-07 6.2915983900339585 0.23041580827549613 SQSLPTTLLS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 SQSLPTTLLSPVR 13 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 SQSLPTTLLS(1)PVR;SQSLPTTLLS(1)PVR 134.02 0.0012636 15177800.0 28936.0 21989.7 30318.0 25742.0 31931.0 26006.0 25028.0 25956.0 18003.8 24761.0 True False 27327.85295998574 23676.239281970255 28367.372887742506 22235.895192573113 27919.542313238137 29588.090441036686 26191.851592041137 26031.527662752873 21605.063068202428 24046.085593195814 1.1364782369284483 0.9846192716152432 1.1797085549661963 0.9247199552040636 1.1610847098181492 1.2304743042838149 1.0892355635402253 1.082568202706509 0.8984856593172857 1.0 14.553514439660585 -8.179773887230986 6.096891081478176 0.9503277828797799 1.0987169209517578 0.3148243479774103 0.08827480600596624 0.2591405397162671 15.190232523507841 0.06151468065324852 0.022509083789994708 6.610375235779504e-09 8.179773887230986 0.14838913807197784 SQSPAAS(ph)DCSSSSSSASLPSSGR ddPTM_A459_Selumetinib_30min_R2 2 SQSPAASDCSSSSSSASLPSSGR 23 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 SQS(0.002)PAAS(0.889)DCS(0.003)S(0.005)S(0.005)S(0.018)S(0.018)S(0.018)AS(0.042)LPSSGR;SQS(0.001)PAAS(0.998)DCSSS(0.001)SSSASLPSSGR 278.98 1.5781999999999995e-136 61855000.0 49234.4 47664.5 58731.3 62560.6 64515.7 43489.2 40616.0 46136.7 35216.3 53831.5 True False 46498.14914891909 51320.21388447642 54952.592099804504 54039.7383569455 56410.660988324096 49479.442544348705 42504.724479077166 46270.95015865814 42260.54402563552 52277.244723965974 0.8894529425649413 0.9816931660315523 1.0511761358113818 1.0337143558786588 1.0790672172220124 0.9464814529841767 0.8130635939883669 0.8851069026873501 0.808392719409361 1.0 15.6738954853381 -7.014706104941461 6.942878331679982 0.8684202078736862 1.0100653032054412 0.4453896961833641 0.06829024357449016 0.13665754008517852 32.939053373636575 0.025305298582194737 0.020660728167973774 9.6670484462664e-08 7.014706104941461 0.14164509533175496 SQSS(ph)DLLER ddPTM_A459_Selumetinib_30min_R2 1 SQSSDLLER 9 0 Q8IVT2 Q8IVT2 MISP Mitotic interactor and substrate of PLK1 1 S(0.018)QS(0.317)S(0.665)DLLER 117.2 0.0076073999999999985 9200900.0 63284.0 58131.0 53855.0 53916.0 46571.0 34636.0 46958.0 41744.0 37829.0 43199.0 True False 59766.928625923996 62589.46077937451 50390.027932890494 46572.54778971225 40720.33462997757 39406.79460569666 49141.64004551174 41865.46812890877 45395.85703057293 41951.73262551859 1.4246593617344114 1.4919398285186034 1.2011429511790657 1.1101459909997349 0.9706472672646665 0.9393365217465682 1.1713852317894409 0.997943720289699 1.0820973101587545 1.0 15.356442775402256 -5.494556954695574 2.035193845347798 1.0327522358898815 1.4695795150316213 0.8595350608495304 0.06731303548658897 0.11385237348778653 0.9158026493984937 0.01967983409988552 0.05265426332237164 3.202160126100551e-06 5.494556954695574 0.4368272791417398 SQSS(ph)DTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 SQS(0.06)S(0.939)DTEQQS(0.67)PT(0.3)S(0.029)GGGK 181.6 1.3268000000000002e-06 24750000.0 5302.5 5391.3 6326.7 6888.4 5443.2 5505.1 5535.4 5418.3 3031.7 4669.0 True False 5426.037933131074 4760.084089652628 5467.5688900755 5685.470251282495 4950.863521075012 5449.723692230875 5117.860321423893 5274.589082881174 5144.573473392822 5268.311629911297 1.0299386813650644 0.9035312305040645 1.037821843915402 1.0791826016902157 0.9397438627142051 1.0344345731732336 0.9714422154465572 1.0011915492876762 0.9765127492048988 1.0 12.363124970733057 SQSS(ph)DTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R2 3 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.005)QS(0.155)S(0.84)DT(0.003)EQQS(0.941)PT(0.056)S(0.002)GGGK;S(0.011)QS(0.387)S(0.601)DT(0.001)EQQS(0.922)PT(0.073)S(0.005)GGGK;S(0.006)QS(0.172)S(0.784)DT(0.037)EQQS(0.8)PT(0.2)SGGGK 238.19 1.1712e-27 42581000.0 159844.0 150461.0 163201.0 183134.0 177567.0 133761.0 142205.0 155705.0 126514.0 158427.0 True False 150960.5103862303 162000.8748916322 152700.8253398136 158190.83327622933 155259.4459908788 152185.36358853753 148817.81427386173 156158.07577164948 151820.33509651103 153852.8008672204 0.9812009240996125 1.0529601929798071 0.9925124825748153 1.0281959924327462 1.0091427982833565 0.9891621259458129 0.9672740010907959 1.014983639501101 0.986789543256587 1.0 17.231191182394703 -6.665982556386851 4.585205685162704 0.9910861883257989 1.0153541180050996 0.19832502937864405 0.02124662848812535 0.31817176238483263 11.661204737755469 0.006808852333578329 0.006737244248981903 2.157831077568261e-07 6.665982556386851 0.024267929679300693 SQSS(ph)DTEQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R1 6 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQS(0.226)S(0.766)DT(0.007)EQQSPTSGGGK;SQS(0.026)S(0.973)DT(0.001)EQQSPTSGGGK;S(0.002)QS(0.159)S(0.816)DT(0.023)EQQSPTSGGGK;SQS(0.011)S(0.989)DTEQQSPTSGGGK;SQS(0.062)S(0.877)DT(0.062)EQQSPTSGGGK;SQS(0.006)S(0.93)DT(0.064)EQQSPTSGGGK 293.35 5.0732999999999996e-76 187118300.0 9928.119999999999 12355.97 12150.06 12707.19 11010.06 10001.580000000002 10011.411000000002 10280.71 5448.5 8726.21 True False 10159.425879241357 10909.327288265391 10500.148587502294 10488.117809998608 10014.202016983974 9900.973185908057 9256.242208036769 10008.032174347549 9245.706557304746 9846.304053983351 1.0318009502389205 1.107961650224684 1.0664050723940857 1.065183215193889 1.0170518767326406 1.0055522490088642 0.9400727579900531 1.0164252616491942 0.9390027472861117 1.0 13.265366575362332 -6.5203069161831415 1.5792519516462877 0.9755893310938657 1.0731958930154764 0.6767424696828018 0.028789153898489347 0.206246199182301 1.0476794829803568 0.010751444017413705 0.011850690556255584 3.0178182725676295e-07 6.5203069161831415 0.09760656192161066 SQSS(ph)DTEQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R2 8 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQS(0.006)S(0.991)DT(0.003)EQQSPTSGGGK;SQS(0.021)S(0.978)DT(0.001)EQQSPTSGGGK;SQS(0.079)S(0.921)DTEQQSPTSGGGK;SQS(0.017)S(0.983)DTEQQSPTSGGGK;SQS(0.099)S(0.9)DT(0.001)EQQSPTSGGGK;S(0.006)QS(0.193)S(0.786)DT(0.015)EQQSPTSGGGK;SQS(0.338)S(0.626)DT(0.036)EQQSPTSGGGK;SQS(0.008)S(0.966)DT(0.026)EQQSPTSGGGK 346.63 1.520599999999999e-155 260027140.0 73479.95000000001 77475.1 76107.90000000001 84123.4 85394.0 63086.7 61632.50000000001 67208.2 55713.8 68358.5 True False 69396.22854254581 83417.19104828939 71211.20057401607 72665.6477990407 74666.04228795397 71776.32028095641 64498.53337248191 67403.76473508356 66858.11677363755 66384.81248828712 1.0453630271952643 1.256570410031774 1.0727031967828562 1.0946125337306898 1.1247458490769704 1.081215982851809 0.9715856828527153 1.0153491771476528 1.0071297073473535 1.0 16.018565599223564 -7.071930004125944 3.650841202731427 1.0002014379292044 1.1218065293481196 0.530666061406464 0.053322715501743286 0.1898148891787403 4.882996821404287 0.02076382183624804 0.016179914627573216 8.473639740211244e-08 7.071930004125944 0.12160509141891529 SQSS(ph)HSYDDSTLPLIDR ddPTM_A459_Selumetinib_30min_R1 1 SQSSHSYDDSTLPLIDR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 S(0.006)QS(0.108)S(0.46)HS(0.365)YDDS(0.06)T(0.001)LPLIDR 217.35 9.4446e-12 4865400.0 1108.5 1411.6 1460.5 1600.5 2293.9 1263.1 1839.8 1529.4 482.29 989.88 True False 1134.3258932344736 1246.3292157649637 1262.1721219522458 1321.0027201059227 2086.4171500209372 1250.3943608030395 1701.0224047685217 1488.8353438086608 818.410904932092 1116.940740247718 1.015564973467527 1.1158418444729212 1.130026040300328 1.1826972304841772 1.8679747947578726 1.1194813795812693 1.522929859637195 1.3329582225449697 0.7327254485771401 1.0 10.125336929732505 -8.253576853860869 24.736318094065744 0.8663627193931753 1.2933791516311637 0.3198475942209478 0.24454313405668548 552.2654192427985 1737499.5843827317 0.1770627697191306 0.06412726222116688 5.57728896277703e-09 8.253576853860869 0.42701643223798835 SQSSDT(ph)EQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.073)QS(0.073)S(0.336)DT(0.517)EQQS(0.994)PT(0.005)S(0.001)GGGK 103.58 0.0052332 0.0 820.92 1284.1 1197.8 1258.8 957.31 1096.2 1389.5 874.22 740.24 771.52 True False 840.0458387677437 1133.7569750381056 1035.1453390444367 1038.9742106025205 870.7214795268075 1085.173223269965 1284.6888963071328 851.0328457332333 1256.1332150095009 870.5521072412005 0.9649575617361587 1.3023424624529454 1.189067639299428 1.1934658499593478 1.0001945573208062 1.246534485694261 1.4757174046460484 0.9775782961805422 1.4429155986885331 1.0 9.76578684331867 SQSSDT(ph)EQQSPT(ph)SGGGK ddPTM_A459_Selumetinib_30min_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.003)QS(0.065)S(0.03)DT(0.902)EQQS(0.082)PT(0.853)S(0.065)GGGK 190.18 6.0952e-07 13237000.0 3135.7 3762.8 4167.0 4285.8 3861.6 3564.2 3363.8 3240.0 2102.5 2936.1 True False 3208.755708989933 3322.2496267217393 3601.144287692573 3537.3654844298435 3512.3189618208544 3528.3473840346724 3110.065857789083 3154.0646749967727 3567.7889394756785 3312.977035035887 0.9685414885331901 1.0027988698948986 1.086981361358445 1.067730155392256 1.060170029757785 1.0650081019944204 0.9387526158192624 0.9520333650494522 1.076913272185429 1.0 11.693912487611751 -7.2421236530518796 24.921473507502235 0.987927586604778 1.044153202078715 0.2091492213877746 0.047201348086002945 1185.337364859883 1529343.6075182941 0.018932613161575802 0.014643612770777338 5.726329667561105e-08 7.2421236530518796 0.05622561547393701 SQSSDT(ph)EQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQS(0.001)S(0.005)DT(0.578)EQQS(0.417)PTSGGGK 146.5 0.0010007 176760000.0 2416.5 2784.6 3527.6 3361.7 2743.2 2641.2 3079.3 2690.7 1585.8 2516.1 True False 2472.799748309522 2458.577737474581 3048.5712957197798 2774.642201924449 2495.0780443512963 2614.6319260177247 2847.025921841348 2619.333895374632 2690.9867777505474 2839.065943889446 0.8709905994370286 0.8659812015871651 1.0737937603320749 0.9773081206149309 0.8788376507144828 0.9209479376994489 1.0028037312655715 0.9226041054144073 0.9478422942384939 1.0 11.47120064405105 SQSSDT(ph)EQQSPTSGGGK ddPTM_A459_Selumetinib_30min_R2 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQS(0.001)S(0.048)DT(0.951)EQQSPTSGGGK 174.4 5.889899999999999e-07 2623800.0 6435.2 6034.5 7442.1 5663.1 7690.1 4955.1 5015.9 3744.5 5311.2 4950.8 True False 6077.557346146678 6497.32674602425 6963.283388345821 4891.776010607603 6724.00088763373 5637.620047080712 5249.149288817295 3755.395875064655 6373.588407327157 4807.857540276802 1.2640884833282262 1.3513975178328974 1.4483131686021056 1.0174544419479554 1.3985441189354813 1.1725846699601123 1.0917855291767 0.7810954970284844 1.3256608279121789 1.0 12.231178433418947 -7.131854651245562 2.810046446560606 1.028390155606521 1.2918714457971454 0.3278451990371831 0.16457196171903354 0.3108475224870238 4.736684912785322 0.06752877412431531 0.05005538496198882 7.381512316796531e-08 7.131854651245562 0.2634812901906245 SQSSDTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R1 10 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQSSDTEQQS(0.976)PT(0.024)SGGGK;SQSSDTEQQS(0.981)PT(0.019)SGGGK;SQSSDTEQQS(0.993)PT(0.005)S(0.001)GGGK;SQSSDT(0.001)EQQS(0.993)PT(0.006)SGGGK;SQSSDTEQQS(0.936)PT(0.064)SGGGK;SQSSDTEQQS(0.646)PT(0.301)S(0.053)GGGK;SQSSDTEQQS(0.999)PT(0.001)SGGGK;SQS(0.006)S(0.025)DT(0.272)EQQS(0.673)PT(0.021)S(0.003)GGGK;SQSSDTEQQS(0.999)PT(0.001)SGGGK;SQSSDTEQQS(0.967)PT(0.033)SGGGK 308.24 5.432899999999996e-103 545406200.0 26211.57 30732.42 33445.159999999996 36671.740000000005 31413.659999999996 27137.07 30013.550000000003 27355.41 16797.01 25197.299999999996 True False 26822.248582163233 27134.253979285564 28903.490973113567 30267.709022816114 28572.299999532137 26864.09571428814 27749.603759452257 26629.85566390538 28503.299164928587 28431.61889748639 0.9433950517863251 0.9543689396344741 1.0165967360961248 1.0645791620923861 1.0049480510607922 0.9448669036803657 0.976012089199239 0.9366281870871481 1.002521146182377 1.0 14.795208628015477 -9.338679485880952 15.635662896733054 1.0000011555844646 0.9832265124951527 0.017901879730386816 0.038327731140966007 0.0 0.0 0.040813139847394694 0.00989864038258314 4.584801252779747e-10 9.338679485880952 -0.01677464308931187 SQSSDTEQQS(ph)PTSGGGK ddPTM_A459_Selumetinib_30min_R2 11 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQSSDTEQQS(0.975)PT(0.025)SGGGK;SQSSDT(0.006)EQQS(0.994)PTSGGGK;SQSSDTEQQS(0.844)PT(0.147)S(0.009)GGGK;S(0.001)QS(0.001)S(0.013)DTEQQS(0.985)PTSGGGK;SQSS(0.015)DT(0.002)EQQS(0.903)PT(0.079)S(0.001)GGGK;SQS(0.031)S(0.026)DT(0.291)EQQS(0.646)PT(0.006)SGGGK;SQSSDT(0.003)EQQS(0.997)PTSGGGK;SQSSDTEQQS(0.993)PT(0.006)S(0.001)GGGK;SQSS(0.026)DT(0.357)EQQS(0.593)PT(0.024)SGGGK;SQSS(0.001)DT(0.006)EQQS(0.751)PT(0.223)S(0.02)GGGK;SQSSDTEQQS(0.713)PT(0.219)S(0.067)GGGK 257.93 1.7292e-40 787008620.0 193286.90000000002 186029.8 194924.5 211678.10000000003 220890.1 163453.3 185759.5 186393.7 159490.69999999998 210771.7 True False 182544.78788676634 200297.68747991376 182383.26988774916 182847.17761490977 193139.9108554508 185967.50839367465 194397.68482546642 186936.07480786176 191393.29654249357 204686.17337035591 0.8918276446375921 0.9785599299738644 0.8910385439555205 0.8933049780752361 0.9435904129488343 0.9085494409883172 0.9497353027052117 0.9132813991769859 0.9350572800840318 1.0 17.643054125485293 -11.28082114095531 0.37090067186883424 1.0654781527368524 0.9194355113400203 0.43114044474006474 0.027106767844521863 31.05989454634977 2.0393739022792894 1.8260168768254081 0.018916770394270206 5.2381611964160125e-12 11.28082114095531 -0.1460426413968321 SQSSDTEQQSPT(ph)SGGGK ddPTM_A459_Selumetinib_30min_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 SQSSDTEQQS(0.024)PT(0.97)S(0.006)GGGK 326.38 4.355499999999998e-119 3376700.0 729.89 804.59 844.19 1112.6 826.95 632.53 799.12 688.77 529.69 467.4 True False 746.8950168812902 710.3882287562573 729.5536348037423 918.3052960886283 752.1525185098808 626.1673224912889 738.8417350247971 670.5015821597301 898.845242973066 527.3953428615424 1.4161957002289518 1.346974785370367 1.3833145185646296 1.7412085800873518 1.426164505793416 1.187282616289005 1.4009257856089297 1.2713452843965622 1.7043101634081752 1.0 9.042741021386332 -6.535220577866587 24.890939201010557 1.332072742648567 1.4725464556915695 0.12935844411252828 0.19424496851724996 517.294545862594 1043268.9679973833 0.06293597599938495 0.06297755184022921 2.9159456310697525e-07 6.535220577866587 0.1404737130430025 SQSSEGVSSLSSS(ph)PSNSLETQSQSLSR ddPTM_A459_Selumetinib_30min_R1 1 SQSSEGVSSLSSSPSNSLETQSQSLSR 27 0 O95155-2;O95155;O95155-4 O95155-2 UBE4B Ubiquitin conjugation factor E4 B 1 SQSSEGVSSLSS(0.014)S(0.983)PS(0.002)NS(0.001)LETQSQSLSR 156.52 4.6677e-17 19137000.0 1496.3 1678.4 1631.9 1931.2 1858.0 1511.7 1474.3 1560.5 834.76 1191.5 True False 1531.160878707031 1481.8921477330082 1410.2969433850521 1593.95217311375 1689.9442280565434 1496.493670513781 1363.0923640342608 1519.1104707816246 1416.5267515418384 1344.4406311928271 1.1388832226444543 1.1022369551701439 1.0489841727959348 1.1855876236792613 1.2569868753201658 1.1130976227533735 1.013873229065448 1.129920083889331 1.0536179275428876 1.0 10.39279033368114 -8.200348141456118 0.7650702642085003 1.0062772238570565 1.136652853820638 0.32301500116637205 0.061867646265224584 0.8602748894913955 1.085217682926849 0.06516193447471325 0.026280390250173428 6.304517557659653e-09 8.200348141456118 0.13037562996358143 SQSSEGVSSLSSS(ph)PSNSLETQSQSLSR ddPTM_A459_Selumetinib_30min_R2 1 SQSSEGVSSLSSSPSNSLETQSQSLSR 27 0 O95155-2;O95155;O95155-4 O95155-2 UBE4B Ubiquitin conjugation factor E4 B 1 SQSSEGVSSLS(0.001)S(0.252)S(0.746)PSNSLETQSQSLSR 143.56 5.4109e-13 14759000.0 27724.0 23052.0 33132.0 35540.0 26666.0 23151.0 23436.0 29392.0 20191.0 26502.0 True False 26183.21106796532 24820.01427613737 31000.323191394084 30699.390690080356 23315.978682935343 26339.84010614631 24525.82043755301 29477.525853892475 24229.76418367651 25736.818399534583 1.017344516385087 0.9643777210856106 1.2045126444982293 1.1928199598531384 0.9059386564796597 1.0234303128401694 0.9529468661128887 1.1453445952909835 0.9414436472891565 1.0 14.651546097330442 -6.262960459069017 24.994251598183972 1.0014517042059046 1.0932896310708133 0.22642567101247935 0.08996085582969479 249.28873006028056 4096292.3673458477 0.028694307824550673 0.03433544116124464 5.458075526190884e-07 6.262960459069017 0.09183792686490877 SQSSHS(ph)YDDSTLPLIDR ddPTM_A459_Selumetinib_30min_R2 1 SQSSHSYDDSTLPLIDR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 SQS(0.01)S(0.002)HS(0.725)YDDS(0.132)T(0.132)LPLIDR 146.18 0.00044183 6150100.0 5845.9 7612.0 9730.9 12566.0 12840.0 7537.0 7880.2 8029.1 8851.0 10142.0 True False 5521.008280991866 8195.815923562282 9104.824488202845 10854.489122440915 11226.924408943592 8575.153335926085 8246.64491432007 8052.463351710936 10621.447317602924 9849.17410791939 0.5605554557668554 0.8321323020345738 0.9244251739729081 1.1020709963603126 1.1398848559207009 0.8706469437910628 0.8372930383766106 0.8175775210670934 1.0784099459732948 1.0 13.265787038635768 -4.78376460596303 1.9679003196554876 0.9673562609303278 0.4400694238202921 0.5868543852003408 0.1055314437379097 0.6135154339940193 2.5838760881545833 0.03166016231244202 0.5952998033819559 1.6452632386118946e-05 4.78376460596303 -0.5272868371100357 SQSSHSYDDS(ph)TLPLIDR ddPTM_A459_Selumetinib_30min_R1 2 SQSSHSYDDSTLPLIDR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 SQSSHS(0.001)YDDS(0.5)T(0.5)LPLIDR;SQSSHSYDDS(0.5)T(0.5)LPLIDR 142.89 0.00032923 8800600.0 3056.95 2988.9700000000003 2448.9700000000003 2877.2200000000003 3810.3 2739.75 3422.33 2584.6 792.07 1445.8899999999999 True False 3128.1709872107563 2639.020002865544 2116.4133252292986 2374.767539108505 3465.6590377631037 2712.1906024939644 3164.1808927663087 2516.0480120360053 1344.0849394960755 1631.4840656612648 1.9173775907782844 1.6175579390632355 1.297231992499715 1.4555873324732573 2.124237135199001 1.662407043733322 1.9394494616064908 1.5421836259345956 0.823841904304041 1.0 10.671969181681975 -8.175935182238428 4.382671532213559 0.9121667736812608 1.701511444564162 0.6500687654223873 0.23174972293946333 0.1411890823033602 4.702014650378765 0.18544484392890778 0.06346306754228286 6.669062964917022e-09 8.175935182238428 0.7893446708829012 SQSSHSYDDS(ph)TLPLIDR ddPTM_A459_Selumetinib_30min_R2 2 SQSSHSYDDSTLPLIDR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 SQSSHSYDDS(0.636)T(0.364)LPLIDR;SQSSHSYDDS(0.678)T(0.322)LPLIDR 185.23 3.8573e-08 8938800.0 36778.0 17400.9 49183.0 63920.0 54005.0 54742.0 22661.0 27471.0 25298.0 47499.0 True False 34734.025993999014 18735.493077287818 46018.61932640151 55213.98573184964 47220.40908917433 62282.21360160083 23714.781401919623 27550.936061931126 30358.306885178943 46127.58045277686 0.7529990875970178 0.4061668288989987 0.9976378313081714 1.196984216164882 1.0236914363526233 1.3502163562505145 0.5141128402821311 0.5972768524058272 0.6581378556427488 1.0 15.493341999715275 -10.820289824074697 4.296448109105768 1.000151737382102 0.8405222434216894 0.028424743161489463 0.28989479133191925 0.00046476348458830805 7.600196783528915e-05 0.3075005518466328 0.07450863275122849 1.5125515184757824e-11 10.820289824074697 -0.1596294939604127 SQSST(ph)SPEGQALENR ddPTM_A459_Selumetinib_30min_R2 1 SQSSTSPEGQALENR 15 0 O60239-2;O60239 O60239-2 SH3BP5 SH3 domain-binding protein 5 1 SQSS(0.037)T(0.481)S(0.481)PEGQALENR 219.53 5.6659e-09 4930800.0 33764.0 34938.0 41085.0 43021.0 36652.0 29784.0 32096.0 33908.0 30129.0 40146.0 True False 31887.53204800105 37617.63225662362 38441.635829965766 37161.46558463555 32047.448086962642 33886.47564776733 33588.52759701748 34006.66666622842 36155.64187459709 38986.88066816525 0.8179041642087264 0.9648792519925892 0.9860146585503902 0.953178734685993 0.8220059552784637 0.8691763759247695 0.8615341115105986 0.8722592339631976 0.9273797045301957 1.0 15.25070110918636 -4.737407533536206 24.41804646309296 0.910420405241558 0.8179036246471257 0.20833887701185239 0.05673181384027387 3045.5623952031997 3094290.156250753 0.015224789889489445 0.9101100438585339 1.830595820458537e-05 4.737407533536206 -0.09251678059443225 SQSSTS(ph)PEGQALENR ddPTM_A459_Selumetinib_30min_R2 1 SQSSTSPEGQALENR 15 0 O60239-2;O60239 O60239-2 SH3BP5 SH3 domain-binding protein 5 1 SQS(0.01)S(0.016)T(0.211)S(0.763)PEGQALENR 165.66 8.4801e-05 5147700.0 17011.0 17213.0 20097.0 22860.0 21221.0 12467.0 12319.0 20033.0 14755.0 22303.0 True False 16065.59672042844 18533.18175148156 18803.980899959137 19746.428564300437 18555.028261852953 14184.21608584191 12891.857909635413 20091.29271335831 17706.412289146007 21659.0544398468 0.7417496809496951 0.8556782477717734 0.8681810626674865 0.9116939347071564 0.8566869026247388 0.6548862105331242 0.5952179466301115 0.927616335660331 0.817506246097752 1.0 14.402682640744969 -8.803399915062876 1.4880188407912414 0.998440101482617 0.7986157608346278 0.25158231568762 0.1027855853937372 1.619183102015956 5.9993932015490925 0.1075005474170492 0.03127711574284818 1.5725341476251728e-09 8.803399915062876 -0.19982434064798915 SQST(ph)TFNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R1 1 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.035)QS(0.275)T(0.552)T(0.137)FNPDDMSEPEFK 155.92 0.00011425 11527000.0 1799.0 2154.0 1785.9 1972.3 1503.3 1717.9 1726.8 1666.6 1046.5 1291.4 True False 1840.913199755362 1901.8086786325673 1543.3845892465004 1627.8748296563022 1367.3267804291713 1700.6194857284013 1596.546085745345 1622.3963541202525 1775.8340666641113 1457.1637693012315 1.2633536727571493 1.3051440879185192 1.059170301761356 1.1171529679446623 0.9383480492963804 1.1670750546755062 1.095653158128515 1.1133932837887237 1.2186921635552983 1.0 10.508947314350856 -5.259388923460337 24.99786507648487 1.0914313354984841 1.2842488967110062 0.518421297938775 0.07535729900373322 136.39794235517022 1662847.7685957241 0.019193070306098993 0.04581895116172527 5.503146527408983e-06 5.259388923460337 0.19281756121252203 SQST(ph)TFNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R2 1 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 SQS(0.093)T(0.697)T(0.209)FNPDDMSEPEFK 186.17 6.059300000000001e-07 7994500.0 44135.0 38340.0 37860.0 37372.0 36201.0 25570.0 35583.0 34122.0 34315.0 32911.0 True False 41682.15338640348 41280.55471746951 35424.12881885123 32281.869129704082 31653.10673895379 29092.035398650634 37237.68000637685 34221.28937079881 41178.95884120942 31960.773916952778 1.3041659596451212 1.291600598431482 1.1083626732849985 1.0100465405996 0.990373600501714 0.9102418944623711 1.1651057043592137 1.0707278071463409 1.2884218307169055 1.0 14.964014722503437 -5.309921775083439 3.478785384711527 1.059998620800479 1.3044514012858548 0.4708692509972413 0.09846914059715794 0.20517022276133978 5.040759867795945 0.027527351631933906 0.06972840397443808 4.898670460430494e-06 5.309921775083439 0.24445278048537578 SQSTT(ph)FNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R1 1 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 SQS(0.039)T(0.22)T(0.741)FNPDDMSEPEFK 326.38 4.355499999999998e-119 33932000.0 3917.2 4794.9 4431.7 5131.1 4797.5 4636.7 4784.7 3975.1 2571.2 3559.1 True False 4008.463138455641 4233.510878911466 3829.899481585598 4235.0497076760375 4363.566972067419 4590.059007786756 4423.786226815929 3869.667435055452 4363.138606982096 4015.945153569782 0.9981369229837488 1.0541754722791195 0.9536732537746917 1.0545586520053674 1.0865603999070144 1.1429585893887628 1.101555439043687 0.9635757678651803 1.0864537338373987 1.0 11.971523850959436 -5.977214989876817 24.43049673382719 1.0678418526481068 1.0066969786553142 0.21099391481658747 0.05299891215552557 291.60372708337485 312659.35518335766 0.015444075470157154 0.022905686359753787 1.0538650697964706e-06 5.977214989876817 -0.06114487399279267 SQSTT(ph)FNPDDMSEPEFK ddPTM_A459_Selumetinib_30min_R2 1 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 SQS(0.025)T(0.062)T(0.913)FNPDDMSEPEFK 214.54 2.0252e-09 34950000.0 87969.0 75414.0 76542.0 80933.0 85097.0 51407.0 76175.0 81833.0 71465.0 65283.0 True False 83080.03514780845 81198.01130577041 71617.37105262854 69909.78578278776 74406.3540831677 58487.847623716574 79717.28843789887 82071.12048181753 85759.99689893733 63398.11016439572 1.310449711077761 1.2807639075552617 1.1296452034125262 1.1027108789442903 1.1736367833398633 0.9225487553501753 1.2574079610762272 1.2945357561763495 1.3527216612065514 1.0 15.952152215228162 -5.184795998160716 5.22838550483728 1.15905270392102 1.3011016063473069 0.17452020027699944 0.12300324734598551 0.41847553709384167 20.38291619386103 0.03321381943412462 0.0924015243560524 6.534374207702925e-06 5.184795998160716 0.14204890242628676 SQSTTFNPDDMS(ph)EPEFK ddPTM_A459_Selumetinib_30min_R2 2 SQSTTFNPDDMSEPEFK 17 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6 Q86W92-2 PPFIBP1 Liprin-beta-1 1 SQST(0.006)T(0.107)FNPDDMS(0.886)EPEFK;S(0.002)QS(0.065)T(0.371)T(0.105)FNPDDMS(0.456)EPEFK 196.67 8.5693e-08 42307500.0 115453.0 113558.0 109435.0 116331.0 120182.0 76320.0 104564.0 109658.0 91716.0 91847.0 True False 109036.58445497771 122267.53345347967 102394.07124381917 100486.51711783162 105083.66271928804 86832.38723601945 109426.43318963521 109977.08662514087 110061.76275915396 89195.13846283496 1.222449859197316 1.3707869684447547 1.1479781634789863 1.1265918619511024 1.1781321777203515 0.9735103138182806 1.226820598918965 1.2329941801813016 1.2339435159351597 1.0 16.444677458454052 -5.282463527701449 22.93438115833257 1.1463557361892815 1.296618376934186 0.31321048434860965 0.09238664133038398 299.2108159432146 326396.9158484024 0.024256560879708258 0.050615052510211304 5.218389267298691e-06 5.282463527701449 0.15026264074490436 SQT(ph)LPIIR ddPTM_A459_Selumetinib_30min_R2 1 SQTLPIIR 8 0 Q96BY6;A0A2R8YD85;Q96BY6-3;H7C0I3 Q96BY6 DOCK10 Dedicator of cytokinesis protein 10 1 S(0.147)QT(0.853)LPIIR 99.283 0.043911 9357100.0 24698.0 16933.0 22777.0 25599.0 20559.0 19789.0 17937.0 18523.0 15021.0 16012.0 True False 23325.38403392754 18231.706651823442 21311.55261772253 22112.37203926189 17976.194620208033 22514.755123343657 18771.106041491206 18576.89886335227 18025.61972180698 15549.691955827782 1.5000544126654258 1.172480246143428 1.3705450036092381 1.422045665089495 1.1560482787230286 1.4479229033797982 1.207168996968849 1.1946795419564527 1.1592268048146932 1.0 13.924598379956672 -8.276291731770556 0.6272087385308268 0.9987564321087762 1.345417941558473 0.5117807938783329 0.10702339635434106 0.6044195939139336 0.5568592540503815 0.1015958543158565 0.04611315728234767 5.293077687126295e-09 8.276291731770556 0.34666150944969687 SQT(ph)PPGVATPPIPK ddPTM_A459_Selumetinib_30min_R1 4 SQTPPGVATPPIPK 14 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 S(0.001)QT(0.999)PPGVATPPIPK;S(0.007)QT(0.993)PPGVATPPIPK;S(0.088)QT(0.899)PPGVAT(0.013)PPIPK;S(0.013)QT(0.986)PPGVAT(0.001)PPIPK 178.0 0.00016609 221758000.0 33414.7 36954.4 42295.7 43934.0 37916.5 34197.1 35104.5 34051.4 20673.699999999997 29646.199999999997 True False 34193.197496312096 32627.76166836552 36552.17625364983 36261.75164331997 34486.95926970178 33853.10822248248 32456.539302204896 33148.24625746454 35081.75895269359 33451.57854844215 1.0221699238137891 0.9753728548599392 1.0926891297735806 1.0840071894008927 1.0309516251904305 1.0120033102013066 0.9702543410680512 0.9909321979966252 1.0487325404357446 1.0 15.029786671440853 -6.752890648326361 3.54085474539913 1.0008354810080138 1.0434925184551391 0.21519251374968473 0.03547162717766288 0.380116586583169 10.107396339246634 0.013760437528979989 0.012905542238654961 1.7664825500446498e-07 6.752890648326361 0.042657037447125346 SQT(ph)PPGVATPPIPK ddPTM_A459_Selumetinib_30min_R2 3 SQTPPGVATPPIPK 14 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 S(0.135)QT(0.863)PPGVAT(0.002)PPIPK;S(0.019)QT(0.981)PPGVATPPIPK;S(0.006)QT(0.994)PPGVATPPIPK 135.61 0.0014075 166616600.0 528274.0 449656.0 511821.0 573049.0 575735.0 413415.0 429760.0 470567.0 346559.0 479832.0 True False 498914.64592837676 484143.16932807676 478890.994088571 494998.73763533786 503406.02216379554 470359.163642282 449744.6915532846 471936.2720634397 415880.4836675119 465978.003406742 1.0706828268305297 1.0389828828582683 1.0277115885029395 1.062279193473569 1.0803214282292708 1.0094020752127988 0.9651629224238559 1.0127865878070148 0.8924895180180832 1.0 18.829902328189732 -7.0160149947938075 3.6792164601264097 0.969404741586975 1.0537291056907179 0.6147921960651779 0.03289081909237137 0.16039959627343747 4.687339602487814 0.012428446735097807 0.010050858192470065 9.637957462774183e-08 7.0160149947938075 0.08432436410374289 SQTGDVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 SQTGDVSPK 9 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2;H0YBM4 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 SQTGDVS(1)PK;SQTGDVS(1)PK;SQT(0.006)GDVS(0.994)PK 111.5 0.010239 44336300.0 18493.0 22502.899999999998 26015.9 24163.2 17780.800000000003 20171.0 17491.6 18789.4 17308.6 17875.199999999997 True False 18923.85091888599 19868.25000668561 22483.083675109487 19943.55071943981 16172.529779455204 19968.098053802645 16172.194529432038 18291.044075427264 29371.430029873354 20169.656039192632 0.9382336953150883 0.9850564614527215 1.1146984178322883 0.9887898276840484 0.801824768257306 0.9900068704692668 0.8018081467530763 0.9068594942762065 1.4562186867639344 1.0 14.299898860883456 -8.232905374772386 24.918349404377828 1.2281094470733802 0.9421338960223371 0.42193139140654856 0.1344599216216571 547.7462440811158 478340.68071481684 0.08846736783073993 0.033423826775970236 5.849175136328297e-09 8.232905374772386 -0.2859755510510431 SQTGDVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SQTGDVSPK 9 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2;H0YBM4 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 SQTGDVS(1)PK 86.11399999999998 0.034274 19571000.0 36591.0 30022.0 27160.0 29934.0 25533.0 22009.0 37602.0 46542.0 27084.0 37453.0 True False 34557.41870537872 32324.590864055004 25412.5551695721 25856.93756096977 22325.316272083848 25040.539972190152 39350.567506949454 46677.4295145571 32501.55679018842 36371.63457541954 0.950120034713345 0.8887307716959307 0.6986915893724023 0.7109094178144044 0.6138111892054366 0.6884634211384302 1.0819026410636798 1.2833470384116956 0.893596264495449 1.0 15.150526142870095 -7.269152680350891 24.161890284158776 1.0883237850723149 0.7529237362872486 0.5680453576918711 0.13013028155493275 272.682181009223 854170.814990589 0.05635544035577086 0.03883067805214063 5.38080581920288e-08 7.269152680350891 -0.33540004878506624 SQTPPGVAT(ph)PPIPK ddPTM_A459_Selumetinib_30min_R2 1 SQTPPGVATPPIPK 14 0 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 S(0.063)QT(0.396)PPGVAT(0.541)PPIPK 103.08 0.016687999999999998 7997700.0 74094.0 80545.0 85560.0 85395.0 91015.0 69991.0 70110.0 73218.0 58634.0 74341.0 True False 69976.15210178262 86722.54250700539 80055.16275068422 73764.05368540826 79580.88201557635 79631.62493496109 73370.25392032947 73431.0522581076 70362.43837084291 72194.58216888526 0.9692715159440489 1.2012333876264396 1.1088804775323813 1.0217394639510695 1.1023109993131102 1.1030138625732095 1.0162847642596498 1.0171269096942739 0.9746221427841163 1.0 16.139602953900678 -7.367376024421759 3.9325917545925986 0.999930460100546 1.0887772856411222 0.3295971177288869 0.057652501646535154 0.2820903114395926 7.73060091656815 0.02526923661626191 0.016459570570272072 4.291646829579424e-08 7.367376024421759 0.08884682554057621 SQTPS(ph)PSTLNIDHMEQK ddPTM_A459_Selumetinib_30min_R2 1 SQTPSPSTLNIDHMEQK 17 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 S(0.175)QT(0.135)PS(0.688)PS(0.001)T(0.001)LNIDHMEQK 126.26 0.0007823999999999999 4514900.0 25884.0 19278.0 25753.0 23212.0 27250.0 22511.0 21680.0 23095.0 19264.0 23123.0 True False 24445.47090186174 20756.560611460027 24096.08001774633 20050.485557066557 23826.6113819091 25611.685915487855 22688.162958105015 23162.20262641692 23117.33828113239 22455.378909230938 1.0886242891146547 0.9243469324370848 1.0730649487210806 0.8929034614875379 1.0610647666298998 1.140559062441802 1.0103665161837185 1.0314768109700176 1.0294788778482529 1.0 14.454773445726447 SQTTS(ph)LENGVFPR ddPTM_A459_Selumetinib_30min_R1 2 SQTTSLENGVFPR 13 0 J3KNG8;Q8TF40;A0A087WX11;Q8TF40-3;Q8TF40-2 J3KNG8 FNIP1 Folliculin-interacting protein 1 1 S(0.081)QT(0.026)T(0.081)S(0.812)LENGVFPR;S(0.062)QT(0.032)T(0.143)S(0.763)LENGVFPR 108.58 0.0062279 9922700.0 3290.6 3683.7 3690.9 4376.7 4069.2 3185.1000000000004 3620.6000000000004 4106.2 1970.65 3016.0 True False 3367.264577607001 3252.4106914943295 3189.696052662472 3612.39150583417 3701.1415784756095 3153.060785839412 3347.4952270382164 3997.2902371826367 3344.0491194186634 3403.132978327794 0.9894601824409407 0.9557107266177047 0.9372822258123458 1.0614899649349583 1.0875688966742196 0.9265170670435392 0.9836510205026087 1.1745912553634021 0.9826383925384654 1.0 11.732647810759532 -5.7594503507468335 24.999711590632504 1.0342374196229358 0.9603070067590732 0.19352949469343517 0.06533348876764879 86.25531134088482 1084090.6838948056 0.018546797469425357 0.030150281096300236 1.7400016064885402e-06 5.7594503507468335 -0.0739304128638626 SQTTS(ph)LENGVFPR ddPTM_A459_Selumetinib_30min_R2 1 SQTTSLENGVFPR 13 0 J3KNG8;Q8TF40;A0A087WX11;Q8TF40-3;Q8TF40-2 J3KNG8 FNIP1 Folliculin-interacting protein 1 1 SQT(0.005)T(0.104)S(0.891)LENGVFPR 119.77 0.0031637 3971900.0 17768.0 16650.0 16735.0 19276.0 17845.0 15168.0 16185.0 17111.0 15565.0 17445.0 True False 16780.525690939547 17927.001461811873 15658.288319690322 16650.575547045275 15603.151563675881 17257.254318605108 16937.634569969083 17160.790177121464 18678.434922436973 16941.317522446647 0.99050889452405 1.0581822481078718 0.9242662678946689 0.9828382901733499 0.9210116948107641 1.018648891725207 0.9997826053096116 1.0129548752264412 1.1025373261370437 1.0 14.04825845665087 -7.761331435462829 1.855897712968795 1.0502799474266487 0.9812729914349283 0.25142988312598846 0.04475898084809183 0.4849360169462628 3.2311599204559975 0.03286315179277854 0.01326986306569752 1.7324813355101538e-08 7.761331435462829 -0.06900695599172035 SQTTTERDS(ph)DTDVEEEELPVENR ddPTM_A459_Selumetinib_30min_R2 2 SQTTTERDSDTDVEEEELPVENR 23 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 S(0.013)QT(0.046)T(0.046)T(0.065)ERDS(0.82)DT(0.01)DVEEEELPVENR;S(0.016)QT(0.055)T(0.034)T(0.034)ERDS(0.861)DT(0.001)DVEEEELPVENR 124.45 5.718300000000002e-06 31660000.0 19426.2 17478.0 22321.3 18298.3 23143.4 12320.9 13567.4 14911.3 17653.5 15610.9 True False 18346.56957324009 18818.506399372258 20885.17185959387 15806.039973671857 20235.919187378895 14017.99213700566 14198.310983293079 14954.689414301389 21184.693280002644 15160.172755010726 1.210182091571232 1.2413121343325315 1.3776341600520958 1.0426028930605464 1.334807954658072 0.9246591291232118 0.9365533765834078 0.9864458443825173 1.397391284541972 1.0 13.887998573122914 -6.757981999531982 24.998973930446876 1.0411342584700736 1.2378426024002136 0.2913600514185384 0.14964801076373976 119.03655511791953 860708.8439040476 0.050509699218704476 0.04858138147150684 1.7458945145746492e-07 6.757981999531982 0.19670834393014003 SQVEDPLPPVFS(ph)GTPK ddPTM_A459_Selumetinib_30min_R2 1 SQVEDPLPPVFSGTPK 16 0 Q13164-2;Q13164 Q13164-2 MAPK7 Mitogen-activated protein kinase 7 1 SQVEDPLPPVFS(0.974)GT(0.026)PK 79.32600000000002 0.024851 3978800.0 26089.0 19183.0 26762.0 23904.0 23867.0 20920.0 21802.0 24342.0 17186.0 27346.0 True False 24639.077822541734 20654.27441693317 25040.162056262463 20648.233963299983 20868.614086312806 23801.54010714788 22815.836199843434 24412.831189964978 20623.680216961235 26556.449926559235 0.927800134832784 0.7777498300432367 0.9429032165635842 0.7775223729226542 0.7858209265178175 0.8962621198605256 0.8591448127644955 0.9192806740915165 0.7765977859990764 1.0 14.696774679258915 SQVEEELFSVR ddPTM_A459_Selumetinib_30min_R2 2 SQVEEELFSVR 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 ; 142.19 0.013044 3899100.0 56628.0 29296.0 41138.0 50877.0 38063.0 25419.0 65868.0 47890.0 37908.0 35947.0 False True 53480.84245984493 31542.90899851295 38491.2258676678 43947.46483227965 33281.185652462606 28920.236519292175 68930.99251496592 48029.351971383716 45490.65923801738 34909.11670847748 1.5320021674125432 0.9035722462394168 1.1026124261207797 1.2589108226163528 0.9533665927554237 0.8284436630351366 1.9745842637784767 1.375839794872841 1.303116879693786 1.0 15.091316232962004 -7.22705526775324 24.999578879009963 1.4447058502731804 1.0888721225071596 0.21798966979253676 0.291429540314956 847.3724421332694 616097.948226779 0.10831449493538074 0.08389616349874573 5.928498744721332e-08 7.22705526775324 -0.35583372776602085 SQWES(ph)PSPTPSYR ddPTM_A459_Selumetinib_30min_R2 1 SQWESPSPTPSYR 13 0 Q92620 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 1 S(0.001)QWES(0.778)PS(0.21)PT(0.007)PS(0.004)YR 137.93 0.0014434 0.0 13329.0 11589.0 11257.0 14376.0 16442.0 8733.2 10007.0 12265.0 11786.0 14153.0 True False 12588.227540214602 12477.839035491757 10532.736875694885 12417.964000016753 14376.408966655019 9936.119027903625 10472.34532849432 12300.689119419949 14143.529328354776 13744.366116089848 0.9158827285223571 0.9078511828118846 0.7663312215879299 0.9034948498264797 1.0459855947685555 0.7229230467218057 0.7619373087155227 0.8949622714881076 1.0290419513634497 1.0 13.746552751495875 -8.176882428969835 4.559096023431476 1.014282523176462 0.8604957741359232 0.31364323354401924 0.08935688633603558 0.2727184746963001 9.757532010016654 0.07026565888027378 0.024288182722233462 6.654532815357218e-09 8.176882428969835 -0.1537867490405389 SRAPTSVT(ph)PVAPGK ddPTM_A459_Selumetinib_30min_R2 2 SRAPTSVTPVAPGK 14 1 Q8IZD4;Q8IZD4-2;F5GZK9 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 S(0.003)RAPT(0.001)S(0.002)VT(0.994)PVAPGK;S(0.013)RAPT(0.005)S(0.003)VT(0.979)PVAPGK 86.22200000000002 0.032676 17481200.0 150061.0 138310.0 154694.0 174169.0 172911.0 126154.0 126077.0 122244.0 90088.0 147810.0 True False 141721.21036177836 148917.93226325544 144741.15645809242 150446.88174171653 151188.3743360469 143530.56838800813 131939.830316836 122599.70980141652 108108.11726903319 143542.34124349873 0.9873129359188096 1.0374495147089582 1.008351648748435 1.0481010720488755 1.0532667436403158 0.9999179833950833 0.9191701150604703 0.8541013664633206 0.75314444736305 1.0 17.131116831489834 -7.385337451976176 2.3067420592677697 0.8541032781847043 1.0273921755485418 0.5834713060059225 0.05916409771743937 0.195431706962257 2.0302671273441715 0.029225552915490373 0.017384824439544144 4.1177743879437934e-08 7.385337451976176 0.17328889736383746 SRDAT(ph)PPVSPINMEDQER ddPTM_A459_Selumetinib_30min_R1 1 SRDATPPVSPINMEDQER 18 1 P17275 P17275 JUNB Transcription factor jun-B 1 S(0.009)RDAT(0.99)PPVSPINMEDQER 72.935 0.026076 5617300.0 1087.6 1151.1 1240.0 1542.5 1529.9 987.66 1516.9 1348.3 730.46 649.79 True False 1112.938963898795 1016.3286768681287 1071.6148108324444 1273.131331311082 1391.5208151257839 977.7250371235298 1402.479011736804 1312.5387041043655 1239.5372693124384 733.1968759905894 1.5179264947019218 1.3861606754597973 1.4615648892183748 1.7364112873380855 1.8978815386328023 1.333509551309216 1.912827315094568 1.7901586150800946 1.6905926769501782 1.0 9.5180568286224 -5.744165542750836 19.826240907193213 1.6674380671289724 1.4483095548658267 0.06072126046153126 0.26448826079464866 45.111150860305656 51769.840550494715 0.0676849825902596 0.11643946556005119 1.8023306042501773e-06 5.744165542750836 -0.21912851226314567 SRDAT(ph)PPVSPINMEDQER ddPTM_A459_Selumetinib_30min_R2 2 SRDATPPVSPINMEDQER 18 1 P17275 P17275 JUNB Transcription factor jun-B 1 S(0.251)RDAT(0.749)PPVSPINMEDQER;S(0.362)RDAT(0.637)PPVS(0.001)PINMEDQER 95.344 0.0055705 18476200.0 10173.2 7553.200000000001 12040.8 13162.900000000001 8994.7 4316.7 6430.9 5303.299999999999 7192.299999999999 4875.5 True False 9607.814270546274 8132.506152634082 11266.108037031803 11370.09031273098 7864.705372361748 4911.286241898911 6729.949592586597 5318.731724991421 8630.960969652639 4734.731646929698 2.0292204473249487 1.7176276839063767 2.3794607333949886 2.40142233195076 1.6610667634060579 1.037289250613327 1.4214004286706987 1.1233438601405057 1.822903939075302 1.0 12.20906694422799 -6.5018604977373515 5.253694204899457 1.2994096928625147 2.1149272392523093 0.6678851866603015 0.2824316263114013 0.11536324501574555 9.380929635898449 0.09166853174540758 0.09916998811773108 3.148759583099072e-07 6.5018604977373515 0.8155175463897946 SRDEDNDEDEER ddPTM_A459_Selumetinib_30min_R2 1 SRDEDNDEDEER 12 1 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 0 116.24 0.01426 1287800.0 2130.6 521.82 800.75 1059.6 687.58 1865.6 3647.0 6719.7 3312.0 2208.2 False True 2012.18978146757 561.8419160842444 749.2306167906795 915.2806520880463 601.2000533568095 2122.5694657693625 3816.5927263934045 6739.253214493783 3974.4925450119626 2144.4435284073747 0.9383272419218116 0.26199893288936854 0.34938230215235117 0.4268149941760428 0.2803524762451105 0.9897996555524792 1.7797590264491103 3.1426582818428703 1.8533910976726535 1.0 11.066387609327862 -7.190040214149294 2.6357685933607073 2.1630679453674637 0.44403941588403173 0.6325676962176583 0.5298641761997891 0.15921325573435594 2.167677881695194 0.22584825832803618 0.15974239904283993 6.45594446480261e-08 7.190040214149294 -1.719028529483432 SRDEDNDEDEERLEEEEQNEEEEVDN ddPTM_A459_Selumetinib_30min_R2 2 SRDEDNDEDEERLEEEEQNEEEEVDN 26 2 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 0 ; 90.758 0.00015725 20719300.0 38024.0 26771.6 34194.3 37632.0 38766.0 32064.0 38153.0 33212.0 32709.4 33476.0 False True 35910.77830213222 28824.895635738296 31994.275965938854 32506.45668117906 33895.86850756284 36480.52495198802 39927.19009873526 33308.64142145743 39252.193976997085 32509.4608989065 1.104625463147564 0.8866617544158618 0.9841527691102078 0.999907589432603 1.0426462811231352 1.1221510275248858 1.228171399793291 1.024583013696724 1.2074083325791904 1.0 14.988572011710513 -6.549665769801582 2.529089405836402 1.1251383564974633 0.985379713333053 0.3289435098653941 0.08209420593055673 0.29779001876927025 3.852721987504238 0.02775494134383702 0.029221115055501255 2.820552775213153e-07 6.549665769801582 -0.13975864316441033 SRDESASET(ph)STPSEHSAAPSPQVEVR ddPTM_A459_Selumetinib_30min_R1 1 SRDESASETSTPSEHSAAPSPQVEVR 26 1 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(0.009)RDES(0.139)AS(0.338)ET(0.486)S(0.024)T(0.003)PSEHSAAPSPQVEVR 85.274 0.00012607 4579300.0 798.63 1182.6 1248.9 1074.7 1052.2 1114.6 1239.2 913.61 539.93 983.47 True False 817.2365251365336 1044.140642224176 1079.3062397166445 887.0238196175169 957.0286957809976 1103.3881359758273 1145.726146314357 889.3780949764811 916.2217750730566 1109.7079543090304 0.7364428829794171 0.9409148039083125 0.972603859894547 0.7993308655427547 0.8624149192270142 0.9943049715840433 1.0324573612953452 0.8014523925173271 0.8256422525542321 1.0 10.115964332132037 SRDPQLCR ddPTM_A459_Selumetinib_30min_R2 1 SRDPQLCR 8 1 Q8TAT6-2;Q8TAT6;I3L4S2 Q8TAT6-2 NPLOC4 Nuclear protein localization protein 4 homolog 0 112.41 0.031517 1969300.0 4180.4 5679.4 5659.4 6704.7 7781.8 4102.6 6165.2 4861.5 5467.3 6409.2 False True 3948.0701034671138 6114.991717850712 5295.280365488821 5791.508293747376 6804.180713825327 4667.695910305204 6451.89401611204 4875.646160135352 6560.91276912558 6224.1497428985385 0.6343147685307018 0.9824621788426009 0.8507636519398472 0.9304898713844754 1.0931903946540773 0.7499330997990248 1.036590423209748 0.7833433258411295 1.0541058682932993 1.0 12.603661054295062 -4.755744815794255 24.904301864005095 0.9339671069749534 0.6343142637265178 0.41287794915650944 0.10978160440020061 168.39836327408702 736384.9131587015 0.025012656917434137 0.2155118632630084 1.7549113556458335e-05 4.755744815794255 -0.29965284324843566 SRDS(ph)FLK ddPTM_A459_Selumetinib_30min_R2 1 SRDSFLK 7 1 P46778;M0R181 P46778 RPL21 60S ribosomal protein L21 1 S(0.213)RDS(0.787)FLK 72.243 0.034041 7007600.0 54897.0 51147.0 65677.0 59627.0 53230.0 31337.0 31684.0 44934.0 35424.0 55812.0 True False 51846.04451010285 55069.81043647396 61451.41332371089 51505.69973768773 46542.77151776226 35653.38730103694 33157.368780654935 45064.75050077585 42509.78982925841 54200.562543009015 0.9565591587534205 1.0160376175574781 1.1337781462129328 0.9502798000817267 0.8587138091201512 0.6578047464497331 0.6117532221984603 0.8314443316896619 0.7843053251620075 1.0 15.726020204814901 -6.297168283645772 2.596421775269723 0.7576399867595746 1.031627006965819 0.5128169904183715 0.10844749867998718 0.21287893932061092 2.8368408638403237 0.03590699557310641 0.044244592726020375 5.044657855439841e-07 6.297168283645772 0.27398702020624455 SRDS(ph)GDENEPIQER ddPTM_A459_Selumetinib_30min_R1 3 SRDSGDENEPIQER 14 1 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7 Q8WX93 PALLD Palladin 1 S(0.015)RDS(0.985)GDENEPIQER;SRDS(1)GDENEPIQER;S(0.001)RDS(0.999)GDENEPIQER 260.07 4.1953e-35 50546300.0 3979.0 4790.5 4142.299999999999 4736.0 4581.0 3867.6 3469.1 3580.81 2314.6 3035.2799999999997 True False 4071.7029582137766 4229.626032956969 3579.7984120251845 3908.9465057304883 4166.6493588412395 3828.6954554998324 3207.4229940115665 3485.8352866898713 3927.7071483045893 3424.887754130897 1.1888573438071741 1.2349677818945872 1.0452308714956988 1.1413356542899102 1.2165798291683205 1.1179039228021084 0.9365045584758106 1.0177954832199867 1.146813393684865 1.0 11.74184099121341 -7.013997002851629 22.612042593305834 1.0268245410541526 1.1618466460143266 0.4850547756733711 0.06815280125990078 172.49739716971737 278667.9127868925 0.026067877297783187 0.021088876169439084 9.68284538552953e-08 7.013997002851629 0.13502210496017408 SRDS(ph)GDENEPIQER ddPTM_A459_Selumetinib_30min_R2 1 SRDSGDENEPIQER 14 1 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;Q8WX93-4;Q8WX93-7 Q8WX93 PALLD Palladin 1 S(0.006)RDS(0.994)GDENEPIQER 117.53 0.011827 27383000.0 22848.0 28119.0 26306.0 29311.0 28665.0 26367.0 29515.0 26482.0 25444.0 28298.0 True False 21578.19962779077 30275.636883164454 24613.500599807216 25318.79123570472 25063.846431648606 29998.814914204995 30887.50598286298 26559.058235668905 30533.51096475981 27480.96321296619 0.7852053605460834 1.101694895063928 0.8956564007259383 0.9213210992458479 0.9120439570263269 1.0916216684883453 1.1239600935199205 0.9664529598124745 1.1110786302553382 1.0 14.746144951326135 -6.75831354952623 24.99996407938782 1.060609576509141 0.9314687385215993 0.3865749083670238 0.08496699749453099 89.3915779751437 714942.9794754884 0.027433107298791493 0.026326781996122352 1.7445621687985532e-07 6.75831354952623 -0.12914083798754172 SREPQAKPQLDLSIDSLDLS(ph)CEEGTPLSITSK ddPTM_A459_Selumetinib_30min_R1 1 SREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 32 2 A0A087WY61;Q14980-2;Q14980;Q14980-5 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 S(0.002)REPQAKPQLDLS(0.286)IDS(0.286)LDLS(0.328)CEEGT(0.092)PLS(0.005)IT(0.001)SK 44.615 0.009315100000000002 17833000.0 1995.0 2922.2 3036.9 3245.3 2674.2 2103.7 2476.8 2689.1 1496.4 2076.0 True False 2041.4796184057516 2580.0674655060775 2624.5056604976185 2678.5692768258364 2432.3190821683575 2082.538688006774 2289.9729819168806 2617.776332572166 2539.2815072682047 2342.4748219524226 0.8715054690339017 1.1014280458116619 1.1203986637987113 1.1434783638755541 1.0383544187429306 0.8890335420002529 0.9775870205547045 1.1175259208934776 1.084016563794588 1.0 11.19381782584875 -11.941085963412235 2.024826707093853 0.7068579604152004 1.0416997036534001 0.014030898019907645 0.0916814562692331 8929221.99299906 863278.7988323792 11979071.311714122 0.02428870728882705 1.1452862232617857e-12 11.941085963412235 0.3348417432381997 SREQSSEAAETGVS(ph)ENEENPVR ddPTM_A459_Selumetinib_30min_R1 1 SREQSSEAAETGVSENEENPVR 22 1 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 SREQSSEAAET(0.014)GVS(0.986)ENEENPVR 115.45 9.4014e-05 0.0 472.3 796.61 736.92 791.0 637.04 672.38 747.4 577.57 440.71 450.51 True False 483.3036710641784 703.3425308660585 636.8503116118097 652.8666989089563 579.4198444785469 665.616467672194 691.0230162648074 562.2509673882363 747.8526818151371 508.3373468390101 0.9507538135246242 1.3836137266711712 1.2528103936724908 1.2843177920502435 1.1398333175430617 1.3093991063438313 1.3593788073250768 1.1060587440298786 1.4711739880327566 1.0 8.989642417256215 -4.7470127280965375 24.969221698889108 1.2616111116547968 0.9507530000107278 0.3191317314732951 0.13367994556777804 852.1029580313041 1474709.945871981 0.03028738137133421 0.6485992284397388 1.7905533765778324e-05 4.7470127280965375 -0.31085811164406896 SREQSSEAAETGVS(ph)ENEENPVR ddPTM_A459_Selumetinib_30min_R2 1 SREQSSEAAETGVSENEENPVR 22 1 Q29RF7 Q29RF7 PDS5A Sister chromatid cohesion protein PDS5 homolog A 1 SREQSSEAAETGVS(1)ENEENPVR 110.75 2.5899e-05 5114300.0 7355.1 10057.0 13891.0 13838.0 15137.0 8835.0 5877.2 7458.6 8734.8 10765.0 True False 6946.332986798144 10828.339561648163 12997.26818337725 11953.24052811852 13235.354733503042 10051.941053855238 6150.501445450867 7480.303291162298 10482.004070703653 10454.186479171003 0.664454666141461 1.0357897846209865 1.2432596461975403 1.1433927022379258 1.2660339242917904 0.9615230294468918 0.5883290352343696 0.7155318403843387 1.002660904470001 1.0 13.35179317862373 -7.004744858939403 24.860370827191907 0.7989249311127532 1.0854395791440243 0.2551928361935273 0.19334374149214922 237.88965931978424 1246412.3621497904 0.07146023404484719 0.06140411113505967 9.891340244126714e-08 7.004744858939403 0.28651464803127114 SRES(ph)LNVDVVK ddPTM_A459_Selumetinib_30min_R1 3 SRESLNVDVVK 11 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9;H0YGB8 Q07866-6 KLC1 Kinesin light chain 1 1 S(0.003)RES(0.997)LNVDVVK;S(0.004)RES(0.996)LNVDVVK;S(0.008)RES(0.992)LNVDVVK 112.12 0.0043195 71382800.0 10233.900000000001 13117.8 10535.3 11371.499999999998 10533.3 11556.800000000001 11879.9 10785.2 6473.9 9163.3 True False 10472.329958297049 11581.961877700225 9104.664126260517 9385.680994492037 9580.564874805163 11440.549084734836 10983.789578437634 10499.141460733083 10985.735465051877 10339.498813100496 1.012846961694918 1.120166662529666 0.8805711273668893 0.9077500915808473 0.9265985758097155 1.106489714011986 1.0623135392714393 1.015440076015127 1.0625017385883906 1.0 13.335878635088308 -6.756118735040628 24.999960954872982 1.051124301444307 0.9695715655131248 0.2594694419216981 0.0673411786132359 205.9615338318043 967744.6997844292 0.02458098447728112 0.02387920786627932 1.753401060778622e-07 6.756118735040628 -0.08155273593118217 SRES(ph)LNVDVVK ddPTM_A459_Selumetinib_30min_R2 1 SRESLNVDVVK 11 1 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9;H0YGB8 Q07866-6 KLC1 Kinesin light chain 1 1 S(0.003)RES(0.997)LNVDVVK 74.85300000000002 0.029909 52610000.0 21909.0 25457.0 27873.0 26806.0 27357.0 25086.0 24224.0 24845.0 18466.0 27277.0 True False 20691.38548867596 27409.470042843535 26079.681525827786 23154.976557070742 23920.16908531697 28541.36879196518 25350.46399894539 24917.294836688823 22159.71598314945 26489.442135842746 0.7811182048518318 1.0347318717503644 0.9845311725360756 0.8741209587702056 0.9030076572639745 1.0774620562260153 0.9570025623394987 0.9406500412091858 0.8365489869326178 1.0 14.69312984060965 SRESASPT(ph)IPNLDLLEAHTK ddPTM_A459_Selumetinib_30min_R2 2 SRESASPTIPNLDLLEAHTK 20 1 O75151 O75151 PHF2 Lysine-specific demethylase PHF2 1 S(0.256)RES(0.109)AS(0.109)PT(0.526)IPNLDLLEAHTK;S(0.103)RES(0.103)AS(0.103)PT(0.692)IPNLDLLEAHTK 77.357 0.003019 5905800.0 41214.0 45398.0 50296.0 40025.0 46500.0 31835.0 27356.0 28598.0 22312.0 48148.0 True False 38923.490872714014 48879.88062242257 47060.010118144295 34573.52595302384 40658.2542847256 36219.98228064306 28628.10820488565 28681.215445346228 26775.023449368044 46757.842136472405 0.8324483999733729 1.0453835846349915 1.0064624021953354 0.7394166277415856 0.8695494151773749 0.7746290381606484 0.6122632460524721 0.6133990392806021 0.5726317175035498 1.0 15.512920730915075 -6.387512914310786 1.061138026388723 0.6752366129994942 0.9593441452096277 0.32435394526355277 0.13615252963896232 0.5095487121616009 1.2135985302219134 0.062006314171495595 0.0825087126397204 4.097199260779587e-07 6.387512914310786 0.2841075322101335 SRGPKS(ph)DDDGFEIVPIEDPAK ddPTM_A459_Selumetinib_30min_R1 1 SRGPKSDDDGFEIVPIEDPAK 21 2 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 S(0.017)RGPKS(0.983)DDDGFEIVPIEDPAK 65.92399999999999 0.0037957 4536700.0 1568.0 1366.6 1886.3 2130.1 1657.3 1692.6 1408.1 1631.4 917.29 1672.9 True False 1604.5313492031157 1206.5978366848965 1630.1508207042239 1758.118021929163 1507.3975076200807 1675.5739807578386 1301.8858833321856 1588.1299724659675 1556.5741337891282 1887.633010425918 0.8500229336639307 0.6392120873180982 0.8635952071723958 0.93138762260386 0.7985649219389088 0.887658761794894 0.6896922633486015 0.8413340748409714 0.8246169277564758 1.0 10.882362590938689 SRGS(ph)TNLFSK ddPTM_A459_Selumetinib_30min_R2 1 SRGSTNLFSK 10 1 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 SRGS(0.618)T(0.382)NLFSK 126.56 0.0018892 7894000.0 72202.0 60425.0 62121.0 75165.0 60954.0 66266.0 55116.0 61773.0 53141.0 73979.0 True False 68189.30188750653 65059.403203001944 58124.20249223082 64927.3973331427 53296.413584326125 75393.53999714447 57679.0032102821 61952.749202929335 63770.684883599315 71843.03404947431 0.9491428471763642 0.9055770550864979 0.8090443737691243 0.9037396344986043 0.7418452504055416 1.0494203229950605 0.8028475408007096 0.8623348111977831 0.887639083278192 1.0 16.132560658299177 SRIPS(ph)PLQPEMQGTPDDEPSEPEPSPSTLIYR ddPTM_A459_Selumetinib_30min_R1 1 SRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYR 32 1 Q96GY3;K7EMY4 Q96GY3 LIN37 Protein lin-37 homolog 1 S(0.044)RIPS(0.951)PLQPEMQGT(0.004)PDDEPSEPEPSPSTLIYR 89.86 9.2987e-08 25169000.0 510.1 628.96 667.5 710.3 675.99 523.87 566.95 835.21 312.99 516.06 True False 521.9843375181823 555.321070804429 576.8571663150453 586.2594389823413 614.8468238557282 518.6003434359023 524.1845050459364 813.0575176555719 531.1211701148594 582.3013278500802 0.8964161896133833 0.9536661591597856 0.9906506111618614 1.0067973589324877 1.0558911588366278 0.890604775624729 0.9001945899407143 1.3962831248513012 0.9121070908009373 1.0 9.18562209839898 SRIPS(ph)PLQPEMQGTPDDEPSEPEPSPSTLIYR ddPTM_A459_Selumetinib_30min_R2 4 SRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYR 32 1 Q96GY3;K7EMY4 Q96GY3 LIN37 Protein lin-37 homolog 1 S(0.101)RIPS(0.881)PLQPEMQGT(0.019)PDDEPSEPEPSPSTLIYR;S(0.063)RIPS(0.725)PLQPEMQGT(0.211)PDDEPSEPEPSPSTLIYR;S(0.043)RIPS(0.91)PLQPEMQGT(0.047)PDDEPSEPEPSPSTLIYR;S(0.107)RIPS(0.88)PLQPEMQGT(0.012)PDDEPSEPEPSPSTLIYR 127.25 5.578699999999998e-19 37505600.0 75308.5 78604.5 94093.0 90776.2 92019.5 56076.5 61555.7 62883.5 50241.2 82889.5 True False 71123.15505381144 84633.21239669599 88039.15882071224 78412.32496232065 80459.1877452324 63800.528863215935 64418.16202030556 63066.48057407618 60290.843856417596 80496.26476221504 0.8835584516114922 1.0513930385055934 1.0937048952616475 0.9741113478240224 0.9995393945657954 0.7925899301251046 0.8002627477261958 0.7834708947101306 0.748989335524027 1.0 16.296634219496525 -6.75683885545701 23.946210313863126 0.809979501492607 1.007007322430305 0.5308003079495014 0.081725890394407 47.752681664450904 248557.20631316013 0.026570054025858648 0.025700977709032558 1.7504960880000568e-07 6.75683885545701 0.1970278209376981 SRIPSPLQPEMQGT(ph)PDDEPSEPEPSPSTLIYR ddPTM_A459_Selumetinib_30min_R1 1 SRIPSPLQPEMQGTPDDEPSEPEPSPSTLIYR 32 1 Q96GY3;K7EMY4 Q96GY3 LIN37 Protein lin-37 homolog 1 SRIPS(0.003)PLQPEMQGT(0.997)PDDEPSEPEPSPSTLIYR 152.26 9.3438e-21 26058000.0 1263.0 1448.6 1469.4 1816.6 1733.8 1467.8 1375.9 1497.8 657.15 1144.6 True False 1292.425442629807 1278.9972385641308 1269.8635508364455 1499.3649118053218 1576.9780961272518 1453.0352646557699 1272.1147552565556 1458.0734784599279 1115.1355536629917 1291.5205593481408 1.0007006340511706 0.9903034290136808 0.9832313869454575 1.160929960388772 1.2210243845620141 1.1250577887735285 0.9849744520510152 1.1289587826583651 0.8634284182249685 1.0 10.334854894152475 -8.257943293064555 24.980906270587997 0.9317142068800557 1.075035462485487 0.3094838899382444 0.08524708474688165 369.27095639733096 2638636.9278901126 0.06846595206449983 0.02360304083172304 5.521495301430549e-09 8.257943293064555 0.1433212556054313 SRLDQELK ddPTM_A459_Selumetinib_30min_R2 1 SRLDQELK 8 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 0 125.71 0.014146 14070000.0 71569.0 76118.0 71643.0 76364.0 65661.0 67979.0 57132.0 60251.0 52220.0 78533.0 False True 67591.48149340689 81956.00584205371 67033.56737900064 65963.09146475232 57412.078163212216 77342.49019807865 59788.75120491031 60426.32043491 62665.45914870919 76265.5482367612 0.886264939492387 1.074613737616189 0.8789495247696837 0.8649133585190313 0.7527917846336111 1.0141209495796735 0.7839549126336862 0.7923147716360813 0.8216745384714018 1.0 16.21874386894678 -5.449861479602476 7.920424932934328 0.8528655256751735 0.9805059274355281 0.20272933813004235 0.09216513695008326 0.4188160733817743 41.154270173450456 0.023106046834930182 0.048174629846425156 3.5492657678890382e-06 5.449861479602476 0.12764040176035463 SRLGDLYEEEMR ddPTM_A459_Selumetinib_30min_R1 3 SRLGDLYEEEMR 12 1 P08670;B0YJC4 P08670 VIM Vimentin 0 ;; 162.93 0.0013255 31166700.0 6722.700000000001 6092.6 13787.1 14578.5 11041.099999999999 8094.500000000001 7246.500000000001 7713.400000000001 4563.1 4554.1 False True 6879.325829902926 5379.275559627103 11914.88754711934 12032.638647337824 10042.434454464525 8013.076679217961 6699.890670809377 7508.815575345707 7743.247424362172 5138.663095690519 1.338738442625708 1.046823942230883 2.3186745901111174 2.341589324551917 1.954289329239447 1.5593699236554417 1.303819796325656 1.4612391268933136 1.5068603020221265 1.0 12.327177353012674 -6.982227352664641 4.426210725600901 1.3622984952830488 1.81562306494988 0.24816721354224602 0.39169609128115673 0.35312549041219954 16.901758636795034 0.16385426646926823 0.13769405202851007 1.0417719202101297e-07 6.982227352664641 0.4533245696668311 SRLGDLYEEEMR ddPTM_A459_Selumetinib_30min_R2 2 SRLGDLYEEEMR 12 1 P08670;B0YJC4 P08670 VIM Vimentin 0 ; 152.38 0.0014015999999999998 7735800.0 56080.0 69903.0 70194.0 65004.0 68405.0 42543.0 32288.0 34511.0 29961.0 64084.0 False True 52963.29810602708 75264.33532642855 65677.79446144869 56150.34306184541 59811.352351540976 48402.91208309715 33789.45597745825 34611.42129639641 35954.03718028486 62233.72840977191 0.8510384876396191 1.209381749247898 1.0553408278706953 0.9022493830375863 0.9610761540385138 0.7777601201135323 0.5429444264527248 0.5561521409821517 0.5777259068193539 1.0 15.925409059924808 -6.831970499778875 2.165426606965451 0.6318365547141022 1.018131479036537 0.5014387598786413 0.15282059112254992 0.2254430457345722 2.167474489692453 0.05991753573403786 0.05267655998030484 1.4724125152612948e-07 6.831970499778875 0.38629492432243484 SRLS(ph)AIEIDIPVVSHTT ddPTM_A459_Selumetinib_30min_R1 2 SRLSAIEIDIPVVSHTT 17 1 P56749 P56749 CLDN12 Claudin-12 1 S(0.011)RLS(0.989)AIEIDIPVVSHTT;S(0.084)RLS(0.916)AIEIDIPVVSHTT 120.32 0.0008091000000000001 16378400.0 2814.7 3237.9 4619.0 3738.2 3822.1 3383.5 3796.9 3694.5 1991.24 2886.3 True False 2880.2770335472023 2858.805162741129 3991.7651703508536 3085.393544704753 3476.391729846563 3349.465061972201 3510.4967760982727 3596.509858572708 3378.9888455845644 3256.784719942809 0.8843928233603914 0.8777998573977992 1.2256767068168237 0.9473741158914963 1.0674306190885134 1.0284576200145705 1.077902618064334 1.104313047328429 1.037522936316129 1.0 11.669232642487465 -5.209381318484955 24.85495837365868 1.0604111331708836 0.881095981241893 0.5213282162991673 0.06898465330493053 232.54118334171986 111025.11212925168 0.016341564844550554 0.043235600043473835 6.174740086043257e-06 5.209381318484955 -0.1793151519289906 SRLS(ph)AIEIDIPVVSHTT ddPTM_A459_Selumetinib_30min_R2 1 SRLSAIEIDIPVVSHTT 17 1 P56749 P56749 CLDN12 Claudin-12 1 S(0.027)RLS(0.973)AIEIDIPVVSHTT 161.02 1.2705e-05 1832700.0 10456.0 4653.9 7953.7 12404.0 8474.5 5198.6 11802.0 10095.0 9241.2 8355.6 True False 9874.897378684365 5010.8391653529325 7441.967601333784 10714.553801906492 7409.857547008754 5914.659961807793 12350.816385219341 10124.374778682788 11089.698220701861 8114.352117544003 1.2169668305783645 0.6175279421901129 0.9171363891448019 1.3204447683186689 0.9131791965236431 0.7289133964275144 1.5220951970417576 1.2477120332001521 1.3666769768007574 1.0 12.986260193468565 -7.261855772342291 24.9999982804227 1.3047637164748673 0.9504906323578125 0.336459601076618 0.22749572138058155 43.15883736379979 2591109.002842785 0.09097943700066399 0.06559133931612915 5.471976551238818e-08 7.261855772342291 -0.3542730841170548 SRLS(ph)LQENQLPK ddPTM_A459_Selumetinib_30min_R2 1 SRLSLQENQLPK 12 1 Q5RGS4 Q5RGS4 PLEKHA1 1 S(0.259)RLS(0.741)LQENQLPK 65.105 0.043619 1229100.0 17501.0 19651.0 19590.0 21855.0 18535.0 19691.0 16710.0 17659.0 18701.0 19668.0 True False 16528.36448205386 21158.16851207599 18329.600727979287 18878.31129802212 16206.467594997623 22403.25651289908 17487.048110236832 17710.384766395175 22441.722549598057 19100.133736398988 0.8653533378436966 1.107749757361909 0.9596582401435597 0.9883863410885891 0.8485002156876563 1.172937154372137 0.9155458465147754 0.9272387832889684 1.1749510688938805 1.0 14.221295119389747 -6.742207427779281 24.99791916242024 1.025925315825283 0.9647077443401652 0.12889146114308958 0.10527994524964966 705.7378771524592 917324.4464145172 0.03412381897504911 0.03407329431058565 1.8104751667303317e-07 6.742207427779281 -0.06121757148511786 SRLS(ph)SSSSNDSGNK ddPTM_A459_Selumetinib_30min_R2 1 SRLSSSSSNDSGNK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 S(0.037)RLS(0.948)S(0.013)S(0.001)SSNDSGNK 96.805 0.0063461 2977000.0 6493.0 5760.5 6174.6 5415.6 6728.9 7523.7 10100.0 14934.0 9033.6 10803.0 True False 6132.145053538407 6202.311827073114 5777.332958396169 4677.985937568917 5883.555424870754 8560.021381651459 10569.67001277032 14977.455467543205 10840.572419873215 10491.089320435147 0.5845098508115705 0.5911980765421465 0.5506895215488011 0.44590087784848675 0.5608145393834773 0.8159325614526756 1.0074902319420835 1.4276358736522485 1.0333123747938477 1.0 13.35687686448057 -7.114255314805055 1.9952601062727948 1.1724510074628511 0.5422897204079022 0.8357425891048373 0.1192964206440089 0.11946345908625879 0.9377095383095736 0.054848739675443035 0.03910129769660851 7.686784136401696e-08 7.114255314805055 -0.6301612870549489 SRLT(ph)PVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R1 4 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 S(0.07)RLT(0.93)PVS(0.53)PES(0.434)S(0.034)S(0.003)TEEK;S(0.002)RLT(0.998)PVS(0.623)PES(0.306)S(0.058)S(0.011)T(0.002)EEK;S(0.303)RLT(0.697)PVS(0.929)PES(0.027)S(0.022)S(0.017)T(0.004)EEK;SRLT(1)PVS(0.996)PES(0.003)S(0.001)STEEK 202.79 4.1742e-05 246761000.0 33588.299999999996 34709.9 40985.9 37943.2 33009.6 34017.8 30410.899999999998 31648.399999999998 19228.7 24966.1 True False 34370.84203854531 30646.04877180526 35420.239899433414 31317.13240207626 30023.887508318214 33675.61181769113 28116.98132904396 30808.981623508596 32629.699491317944 28170.74212540767 1.220090045393077 1.0878679956452078 1.2573413842543857 1.111690003148011 1.0657826256284233 1.19541088650691 0.998091608800209 1.0936517570732174 1.1582832765306763 1.0 14.781909949884323 -1.5228787483643473 0.059190269976402386 0.8392941438261721 1.6948685956721201 0.3251560155608483 0.06873860140333561 429.2109216122683 1.9070451993469708 5.662275637216493 31.806552744667016 0.029999999786964153 1.5228787483643473 0.855574451845948 SRLT(ph)PVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R2 1 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 S(0.323)RLT(0.683)PVS(0.994)PESSSTEEK 88.471 0.046886 4128400.0 29408.0 23821.0 25840.0 25290.0 24490.0 20238.0 20564.0 18156.0 18416.0 26105.0 True False 27773.621089551456 25647.99410341266 24177.482532464775 21845.458372316614 21413.347256622157 23025.600797727464 21520.26674679297 18208.8309541124 22099.71458603271 25351.28082106445 1.0955510013708765 1.011704074616288 0.9536986593740714 0.8617102436167707 0.8446653014403023 0.9082618334058856 0.8488828197158276 0.7182607885824306 0.8717395677961168 1.0 14.629771017804423 -5.170179673941615 1.04228784330522 0.8480672572736047 1.1391389391977873 0.564960167479114 0.06704615081104809 0.731893677188253 0.988014782571258 0.02263027626983325 0.2054111968065384 6.758033278862205e-06 5.170179673941615 0.29107168192418265 SRLT(ph)PVSPES(ph)SSTEEK ddPTM_A459_Selumetinib_30min_R2 2 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 2 S(0.026)RLT(0.974)PVS(0.047)PES(0.783)S(0.154)S(0.014)T(0.003)EEK;S(0.01)RLT(0.989)PVS(0.174)PES(0.677)S(0.123)S(0.023)T(0.004)EEK 191.61 0.00010256 198891000.0 486220.0 450250.0 481910.0 503620.0 470180.0 406260.0 436000.0 422320.0 359140.0 477040.0 True False 459197.8388928767 484782.7272180661 450904.4352639348 435026.0872070429 411111.78493746876 462218.6273389055 456274.86391761014 423548.88128115993 430978.0352100239 463266.6157012297 0.991217202642167 1.0464443385031494 0.9733151925515229 0.9390404412123672 0.8874194060264496 0.9977378288726074 0.984907715024886 0.9142659257672809 0.9303023801049601 1.0 18.821483195880667 -5.474109709483332 4.808952054250043 0.9480953401198353 1.018212032368969 0.3527646624250852 0.03645395404137547 0.21500888840750892 10.961302246190504 0.00994071547879649 0.02070395338603265 3.356528124557979e-06 5.474109709483332 0.07011669224913364 SRLT(ph)PVSPESSSTEEK ddPTM_A459_Selumetinib_30min_R1 10 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.101)RLT(0.887)PVS(0.012)PESSSTEEK;S(0.001)RLT(0.999)PVSPESSSTEEK;S(0.002)RLT(0.775)PVS(0.218)PES(0.005)S(0.001)STEEK;SRLT(0.999)PVS(0.001)PESSSTEEK;S(0.136)RLT(0.852)PVS(0.012)PESSSTEEK;S(0.001)RLT(0.878)PVS(0.119)PES(0.002)S(0.001)STEEK;S(0.012)RLT(0.987)PVS(0.001)PESSSTEEK;S(0.231)RLT(0.759)PVS(0.01)PESSSTEEK;S(0.029)RLT(0.971)PVSPESSSTEEK;S(0.14)RLT(0.86)PVSPESSSTEEK 192.72 1.1655e-05 3338286500.0 32705.899999999994 35552.90000000001 41742.600000000006 40207.600000000006 32369.729999999996 33783.939999999995 27614.78 28342.93 19661.43 22882.389999999996 True False 33467.8838353968 31390.3499399052 36074.18419568899 33186.09745012863 29441.893636840014 33444.10423696323 25531.774911813078 27591.183425588337 33364.01069596923 25819.5676498535 1.296221698568477 1.215758155426871 1.3971645336940286 1.2853080229760134 1.1402938281581592 1.2953007072197427 0.9888536964699308 1.0686152378599139 1.2921986591111077 1.0 14.656177222385312 -6.739497160867838 1.2928521033201907 1.1021227943013021 1.2963067823015346 0.3974465128562539 0.10374090421340282 0.46629279106256516 1.6372240596070735 0.049666038352148285 0.04570912132318878 1.8218089828438576e-07 6.739497160867838 0.1941839880002325 SRLT(ph)PVSPESSSTEEK ddPTM_A459_Selumetinib_30min_R2 6 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.005)RLT(0.994)PVSPESSSTEEK;S(0.002)RLT(0.998)PVSPESSSTEEK;S(0.061)RLT(0.939)PVSPESSSTEEK;S(0.187)RLT(0.796)PVS(0.017)PESSSTEEK;S(0.358)RLT(0.642)PVSPESSSTEEK;S(0.011)RLT(0.664)PVS(0.325)PESSSTEEK 148.19 0.000409 3514178200.0 1235371.0 1191462.0 1268757.0 1263979.0 1233619.0 997992.0 1088563.0 976242.0 906852.0 1238708.0 True False 1166714.0254019394 1282843.3042458468 1187126.5559381754 1091822.8797146068 1078640.7525262132 1135456.3391306277 1139183.3364466643 979082.7025944362 1088247.7395619545 1202943.2814900998 0.9698828227019292 1.06642044058534 0.9868516447988037 0.9076262335179702 0.8966680051532341 0.9438984834963496 0.9469967154524066 0.8139059568807226 0.9046542395697404 1.0 20.198137190689366 -5.656383407094908 3.895999506150693 0.9099694737068044 1.0199368891711662 0.41730798592960205 0.04986497464546093 0.19201774048411405 5.412537279509893 0.013759745526738596 0.024867610132846166 2.206056305994937e-06 5.656383407094908 0.10996741546436184 SRLTPVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R1 3 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 SRLTPVS(0.998)PES(0.002)SSTEEK;SRLTPVS(0.967)PES(0.032)SSTEEK;S(0.002)RLT(0.002)PVS(0.992)PES(0.004)SSTEEK 220.78 3.6454e-10 372626000.0 10331.3 8551.8 22463.0 20985.2 15421.600000000002 12230.7 9335.9 9981.8 6629.800000000001 6641.799999999999 True False 10571.999188789643 7550.551280376035 19412.64798042677 17320.528760991452 14026.719002904612 12107.67026258708 8631.685546623787 9717.050238544067 11250.286378566401 7494.339726610593 1.4106645247547323 1.0075005345121797 2.590307977565674 2.3111480654513743 1.8716417342409921 1.615575314739958 1.1517606435660706 1.2965852353932081 1.5011711223364144 1.0 12.871585662754429 -7.03845913715238 3.4220522564704696 1.2646003138915975 1.8568602880387506 0.3055586461684199 0.42525932761537577 0.3559985251572831 8.51846550600991 0.18608428367258234 0.14769131323592144 9.15252371493901e-08 7.03845913715238 0.592259974147153 SRLTPVS(ph)PESSSTEEK ddPTM_A459_Selumetinib_30min_R2 2 SRLTPVSPESSSTEEK 16 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.005)RLT(0.003)PVS(0.988)PES(0.003)S(0.001)STEEK;S(0.079)RLT(0.079)PVS(0.834)PES(0.006)S(0.001)STEEK 156.83 0.0003834 112516400.0 83594.0 114966.0 89432.0 109374.0 93253.0 51055.0 52684.0 49653.0 44479.0 93593.0 True False 78948.18013329581 123783.52252604607 83678.04248619935 94477.07251932616 81537.72444760244 58087.362818854475 55133.910391365534 49797.48200950333 53376.04284709756 90890.72690618227 0.8686054432680069 1.361893855836535 0.9206444412373566 1.0394577723736957 0.8970961859702801 0.6390900897823433 0.6065955490517195 0.5478829766748864 0.5872550992159244 1.0 16.471845491032674 -6.553620708653098 2.135227255279541 0.6390570728400158 1.0668974657322432 0.5061279218157251 0.1709779371027945 0.22690151074573883 2.090851486808495 0.05991522268938502 0.06331579329565634 2.794983776384503e-07 6.553620708653098 0.4278403928922274 SRNEVVT(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 SRNEVVTPEK 10 1 Q99728-3;Q99728-2;Q99728;A0A494C142;A0A087X2H0 Q99728-3 BARD1 BRCA1-associated RING domain protein 1 1 SRNEVVT(1)PEK;SRNEVVT(1)PEK 143.55 0.011172 15046200.0 5166.7 7449.5 5752.8 6373.9 6031.799999999999 5271.5 5153.0 5381.2 3369.0 4752.5 True False 5287.07405735188 6577.30907682141 4971.601357868455 5260.818017921363 5486.224755000783 5218.473496139045 4764.305061295901 5238.473095398959 5716.946937975532 5362.529668270173 0.9859291014528534 1.2265310373458682 0.9271000190982959 0.9810328974120865 1.0230665552234626 0.9731365267807279 0.8884435809252604 0.9768660351465746 1.0660914328926567 1.0 12.388698009026783 -5.282706573181635 24.99624988628705 0.9767770250700479 1.1062301101336263 0.33950409596521014 0.07064398608426693 731.2288673722428 859443.6877327678 0.017782762460093797 0.037073074248972535 5.2154697020004064e-06 5.282706573181635 0.12945308506357833 SRNTDEMVELR ddPTM_A459_Selumetinib_30min_R1 5 SRNTDEMVELR 11 1 P61978;P61978-2;P61978-3;Q5T6W2;S4R457 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;;;; 154.15 0.0015444 25733800.0 10524.9 11722.400000000001 22131.0 23172.6 16288.699999999999 13165.1 12521.0 10676.3 7590.0 7686.4 False True 10770.109692109625 10349.935958404096 19125.73175688129 19125.94041357482 14815.389961003559 13032.671046954396 11576.53088928506 10393.129842490129 12879.675648333117 8673.024311876246 1.241794016115206 1.1933479702382017 2.2051975261607213 2.2052215842846263 1.7082149695713844 1.502667417766643 1.3347744077498953 1.1983282265516642 1.4850270430692292 1.0 13.08231943830914 -7.052156127358997 2.348643590532384 1.264966688661663 1.7350511753196203 0.294045022276889 0.33256670666728233 0.45136330001956776 4.938539132861046 0.1603715469101067 0.12249695390958694 8.868371398507219e-08 7.052156127358997 0.4700844866579572 SRPCS(ph)LPVSELETVIASACGDPETPR ddPTM_A459_Selumetinib_30min_R1 2 SRPCSLPVSELETVIASACGDPETPR 26 1 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(0.088)RPCS(0.697)LPVS(0.212)ELET(0.002)VIASACGDPETPR;S(0.208)RPCS(0.792)LPVSELETVIASACGDPETPR 113.66 5.9043e-09 26073000.0 2710.5 2413.86 2664.84 3052.9799999999996 2698.0 2403.41 2444.26 2529.23 1241.7 2134.84 True False 2773.6493762851064 2131.244149026931 2302.969364918332 2519.8343545323205 2453.9663763705894 2379.233877521681 2259.8875003149847 2462.1466043031132 2107.0742098201904 2408.8675091025566 1.1514329309537046 0.8847494272613373 0.9560382031041309 1.0460659812174997 1.0187220206580954 0.9876981064882576 0.938153506481942 1.022117901876806 0.8747156918585357 1.0 11.234139330286128 -7.034290474354289 7.100611777372251 0.9607692670660551 1.0032579860208124 0.09795956791231664 0.07315861568487164 0.6677054528768985 110.16928990137352 0.02699051402398701 0.021369624869145204 9.24079903823452e-08 7.034290474354289 0.042488718954757254 SRPCS(ph)LPVSELETVIASACGDPETPR ddPTM_A459_Selumetinib_30min_R2 2 SRPCSLPVSELETVIASACGDPETPR 26 1 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(0.066)RPCS(0.933)LPVSELETVIASACGDPETPR;S(0.267)RPCS(0.653)LPVS(0.079)ELETVIASACGDPETPR 103.04 3.8719e-07 11032700.0 15341.8 15456.0 16351.4 19353.4 22928.8 19453.1 16616.1 16902.8 20617.0 22168.6 True False 14489.164174091407 16641.425501126992 15299.368726058225 16717.43353352284 20048.27915792724 22132.58794734026 17388.781574177527 16951.984349590828 24740.976087111023 21528.534917059926 0.6730213751150206 0.7729938690783725 0.7106553597353481 0.7765244406053563 0.9312421507159933 1.0280582507173612 0.8077085431576712 0.7874193211428202 1.1492178256638101 1.0 14.39396252256545 -4.933358704148108 0.2847358422409355 1.0131580733781735 0.42839223377514196 0.51823383955526 0.10206616620954961 7.042106212915422 0.5067946802435984 0.1326949054775658 1.4356555082433573 1.1658462922455718e-05 4.933358704148108 -0.5847658396030315 SRPT(ph)SFADELAAR ddPTM_A459_Selumetinib_30min_R1 2 SRPTSFADELAAR 13 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 S(0.092)RPT(0.454)S(0.454)FADELAAR;S(0.056)RPT(0.841)S(0.103)FADELAAR 169.15 0.0027096 27907000.0 4282.6 5309.700000000001 5683.8 5659.3 6237.2 5007.6 5773.6 6390.3 3842.8 4324.700000000001 True False 4382.376247511014 4688.037855587437 4911.971178878585 4671.0094932180245 5673.046361267097 4957.228090537016 5338.09270364797 6220.808485380205 6520.950932992694 4879.8173711453 0.8980615285777518 0.9606994481613453 1.0065891416189903 0.9572098990503269 1.1625530075802049 1.015863446007109 1.0939123941835371 1.2748035453466513 1.3363104470981908 1.0 12.25261144009916 -6.594211043357052 0.736749800106079 1.2059832646145747 0.9322115393986661 0.4663158197029432 0.1001882206272923 0.6041374346754985 0.730208471930063 0.06815654971427966 0.0812885937528013 2.545592933083797e-07 6.594211043357052 -0.27377172521590865 SRPTPQDYEMRVS(ph)PSDTTPLVSR ddPTM_A459_Selumetinib_30min_R1 1 SRPTPQDYEMRVSPSDTTPLVSR 23 2 Q9HCK8-2;Q9HCK8;H0YJG4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 SRPT(0.001)PQDY(0.001)EMRVS(0.878)PS(0.067)DT(0.023)T(0.023)PLVS(0.008)R 57.142 0.018571 5238600.0 736.63 791.13 1454.0 1822.2 1179.7 1183.4 782.39 973.97 423.69 564.24 True False 753.792045767533 698.5041318136415 1256.5547862503008 1503.9869769303418 1072.996343292952 1171.4960704412301 723.3736923941968 948.1371516995699 718.9709849067533 636.6657001630224 1.1839683613779093 1.097128574124199 1.9736492572609956 2.362286795951527 1.6853371290744958 1.84004897725959 1.136190770460812 1.4892229178622207 1.1292755126004999 1.0 9.314392232090322 -7.2643854035256625 24.88189332634861 1.229440860633961 1.7066208694512934 0.31383195579786904 0.36096580107813664 367.582480138817 3104549.4194715 0.16323281278226506 0.11546359714546343 5.4401966223588245e-08 7.2643854035256625 0.47718000881733236 SRPTS(ph)EGS(ph)DIESTEPQK ddPTM_A459_Selumetinib_30min_R2 3 SRPTSEGSDIESTEPQK 17 1 Q4G0J3;Q4G0J3-3;H0YA82;D6RFF0 Q4G0J3 LARP7 La-related protein 7 2 S(0.008)RPT(0.058)S(0.887)EGS(0.797)DIES(0.242)T(0.008)EPQK;S(0.234)RPT(0.335)S(0.49)EGS(0.94)DIESTEPQK;SRPT(0.101)S(0.899)EGS(0.915)DIES(0.075)T(0.009)EPQK 156.83 0.0015198 28061000.0 159212.0 153794.0 166189.0 165941.0 169226.0 128088.0 137799.0 146740.0 113505.0 161711.0 True False 150363.63441613404 165589.50527434805 155496.58067290162 143339.5495358083 147966.3169803651 145730.95933290443 144206.9265435384 147166.98910588512 136209.17159468107 157041.98325436303 0.9574741180680839 1.0544282607927873 0.9901593029492101 0.9127466844559603 0.9422086623848991 0.9279745219268023 0.9182699018132271 0.9371187631241051 0.8673424059734475 1.0 17.260790771999275 -5.660294677806059 4.924962064752822 0.9268884161501083 1.0094141555954843 0.42777423017850214 0.0378277719049147 0.1670664038759131 6.600070495492696 0.009676358447213623 0.01706379232279321 2.1862776858480066e-06 5.660294677806059 0.082525739445376 SRPTS(ph)EGSDIESTEPQKQCSK ddPTM_A459_Selumetinib_30min_R1 1 SRPTSEGSDIESTEPQKQCSK 21 2 Q4G0J3;Q4G0J3-3;H0YA82;D6RFF0 Q4G0J3 LARP7 La-related protein 7 1 S(0.01)RPT(0.325)S(0.402)EGS(0.263)DIESTEPQKQCSK 69.619 0.047697 0.0 159.5 64.195 784.6 566.11 222.82 158.53 224.24 258.18 127.34 178.36 True False 163.2160396670262 56.67901955655414 678.0556294993025 467.24951570082084 202.66597034206617 156.93533213372334 207.32539626334028 251.33222771316855 216.0866794543794 201.25424337352314 0.8109942773435145 0.281628941613714 3.369149480445226 2.321687770993314 1.007014644485895 0.7797864507256875 1.0301665832632867 1.2488294582027861 1.073699991772733 1.0 7.652875392030049 -6.309190362781248 23.18919371558017 1.0238629755238964 1.7143688462744493 0.15116043897000853 0.7803540750359892 373.65669995362686 181456.48273091708 0.2644079530068018 0.29981191683478614 4.906927453724727e-07 6.309190362781248 0.6905058707505529 SRPTS(ph)FADELAAR ddPTM_A459_Selumetinib_30min_R2 1 SRPTSFADELAAR 13 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2;A0A087WYF6 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 S(0.013)RPT(0.228)S(0.759)FADELAAR 148.18 0.0026267 12369000.0 21065.0 17944.0 25133.0 27923.0 32254.0 20916.0 21453.0 23958.0 20432.0 31080.0 True False 19894.29162987627 19320.24710094607 23515.97014274137 24119.839230138263 28201.964165581503 23796.989143456267 22450.60700831303 24027.7138135396 24518.970917779123 30182.639644462113 0.6591302770142723 0.6401112470125169 0.7791223835870188 0.7991295497762653 0.9343769961072963 0.788433000684303 0.7438251681354268 0.7960772847098609 0.8123534325228524 1.0 14.881431362864205 -3.288607185802533 0.05619908295591085 1.290414230734832 1.9826724087049709e-22 0.5737084018245482 0.06758008813697956 247.8504077382058 1.4819837395639237 9.158297632521226 30.09776323556861 0.0005145088082887253 3.288607185802533 -1.290414230734832 SRPTSEGS(ph)DIESTEPQK ddPTM_A459_Selumetinib_30min_R1 3 SRPTSEGSDIESTEPQK 17 1 Q4G0J3;Q4G0J3-3;H0YA82;D6RFF0 Q4G0J3 LARP7 La-related protein 7 1 SRPTSEGS(0.883)DIES(0.115)T(0.002)EPQK;S(0.001)RPT(0.13)S(0.072)EGS(0.797)DIESTEPQK;SRPTSEGS(0.91)DIES(0.089)T(0.001)EPQK 200.89 2.6905e-08 237796000.0 24071.8 30949.5 29204.0 29456.7 27788.0 24354.0 27493.899999999998 25200.4 12673.7 23768.199999999997 True False 24632.62610443087 27325.918151967802 25238.25720608926 24312.64031574141 25274.580306369873 24109.020871662775 25420.012987534115 24532.0035295644 21506.34324957568 26819.079991873557 0.9184739413840741 1.0188984171063222 0.9410560397201059 0.9065426675004652 0.9424104150488501 0.8989503323368304 0.9478331469698672 0.9147220388245174 0.8019045864396658 1.0 14.710972127085379 -5.516949567708938 8.523537060650007 0.9148887709826437 0.9715445034327806 0.14024005633121917 0.05218741611450538 0.2118929728638062 151.92295461872348 0.013417935493616348 0.025169295857882353 3.041238167863906e-06 5.516949567708938 0.056655732450137 SRPTSEGS(ph)DIESTEPQK ddPTM_A459_Selumetinib_30min_R2 4 SRPTSEGSDIESTEPQK 17 1 Q4G0J3;Q4G0J3-3;H0YA82;D6RFF0 Q4G0J3 LARP7 La-related protein 7 1 SRPT(0.004)S(0.011)EGS(0.985)DIESTEPQK;S(0.008)RPT(0.05)S(0.038)EGS(0.904)DIESTEPQK;SRPT(0.001)S(0.002)EGS(0.996)DIES(0.001)TEPQK;SRPTSEGS(1)DIESTEPQK 290.92 4.0422999999999995e-75 284496000.0 379763.0 340332.0 357426.0 378227.0 396753.0 305752.0 329439.0 331022.0 266087.0 366412.0 True False 358657.29277173994 366434.370060141 334429.60029600415 326711.8301220328 346909.3411231769 347866.56265968864 344758.5662709941 331985.21921635745 319311.8350919682 355832.73350729275 1.0079378848500156 1.0297938766013808 0.9398505781063845 0.9181612576835539 0.974922508403986 0.9776125968820099 0.9688781660777936 0.9329811115017991 0.897364983667035 1.0 18.44083970650466 -5.261798850888537 24.9999865438425 0.9500667578068684 1.0188658851491625 0.45791476196825165 0.029418276550953817 26.63930377075503 1852857.4602349584 0.007854451673829727 0.01814158201120627 5.472693791005619e-06 5.261798850888537 0.0687991273422941 SRPTSEGSDIES(ph)TEPQK ddPTM_A459_Selumetinib_30min_R1 1 SRPTSEGSDIESTEPQK 17 1 Q4G0J3;Q4G0J3-3;H0YA82;D6RFF0 Q4G0J3 LARP7 La-related protein 7 1 S(0.001)RPTS(0.002)EGS(0.247)DIES(0.734)T(0.016)EPQK 158.33 2.017e-05 42006000.0 5774.5 7772.0 7655.5 7253.4 6886.1 6342.1 6820.0 5939.0 3235.4 5461.2 True False 5909.034614778953 6862.050626895226 6615.925148651432 5986.729853181068 6263.253470839697 6278.304232166069 6305.561909186499 5781.478427409204 5490.23749573346 6162.198216592757 0.958916673414997 1.1135718757663458 1.0736306941306983 0.9715250374551065 1.0163992216243276 1.0188416554437794 1.0232650245179897 0.9382168869286938 0.8909543806867605 1.0 12.589229374292852 -7.757625751334764 5.875459308057356 0.9351078042496368 1.028095189966785 0.3698450023728116 0.04873400101755384 0.15388197204751664 18.94472714464233 0.025413178019543237 0.013235649357197173 1.7473272450564126e-08 7.757625751334764 0.09298738571714815 SRPYGSSHS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SRPYGSSHSPR 11 1 Q8TAP9 Q8TAP9 MPLKIP M-phase-specific PLK1-interacting protein 1 SRPYGS(0.001)S(0.009)HS(0.99)PR 74.133 0.030661 949920.0 2324.5 1078.4 1009.4 3711.6 4989.2 2717.3 3232.2 2766.1 3797.8 4589.3 True False 2195.3135957107697 1161.1098123974737 944.4563029516229 3206.073677132872 4362.412091986085 3091.583409806548 3382.5037044827977 2774.148893047495 4557.46611939808 4456.7949845666035 0.4925767515250089 0.26052574022773556 0.21191378697520805 0.719367547359741 0.9788226981704664 0.6936786234305965 0.7589542970219721 0.6224537818441439 1.0225882355325049 1.0 12.12179088224001 -5.855053687372705 5.207143450418668 0.8172290521286053 0.31730899884223374 0.7255539186910841 0.14350586579798275 0.1063538981324294 4.645007550570982 0.04009030303841036 0.060942769349209815 1.3961957530256122e-06 5.855053687372705 -0.49992005328637157 SRQPS(ph)PLLLLPPPAGLTSDPGPSVR ddPTM_A459_Selumetinib_30min_R1 2 SRQPSPLLLLPPPAGLTSDPGPSVR 25 1 I3L2J0 I3L2J0 CIC 1 S(0.349)RQPS(0.651)PLLLLPPPAGLTSDPGPSVR;S(0.263)RQPS(0.737)PLLLLPPPAGLTSDPGPSVR 79.054 0.00012394 82767000.0 1830.5 2460.7 2878.4 2850.2 2377.3 1771.9499999999998 2104.85 1837.29 1295.23 1633.32 True False 1873.1470884670316 2172.6001000516044 2487.5290899194392 2352.4660748802885 2162.2736347464056 1754.1257918018725 1946.0794698755437 1788.559100840994 2197.910710143677 1842.9725318840703 1.0163727652262478 1.1788564736939167 1.3497374740449544 1.2764520545921338 1.173253316225996 0.951791609182927 1.0559459982217245 0.9704751806650913 1.1925900533616491 1.0 10.847818853509201 -6.61448536627923 6.1701099100166 1.0344560453767628 1.2150587808850923 0.4044177656159209 0.10020734462476273 0.21452922457146492 11.869867351319733 0.034402950867713944 0.034370692393048824 2.429487303156862e-07 6.61448536627923 0.1806027355083295 SRQPS(ph)PLLLLPPPAGLTSDPGPSVR ddPTM_A459_Selumetinib_30min_R2 2 SRQPSPLLLLPPPAGLTSDPGPSVR 25 1 I3L2J0 I3L2J0 CIC 1 S(0.267)RQPS(0.733)PLLLLPPPAGLTSDPGPSVR;S(0.301)RQPS(0.699)PLLLLPPPAGLTSDPGPSVR 84.741 5.7643e-05 33261000.0 123160.0 113599.0 134507.0 145742.0 144683.0 90710.0 83206.0 99923.0 78601.0 133046.0 True False 116315.26024854308 122311.67802164392 125852.96606014855 125891.68818102666 126506.62805756892 103204.47911660542 87075.24386956116 100213.7593868569 94323.39629543635 129204.61628497796 0.9002407467547003 0.9466509907964066 0.9740593616451219 0.9743590577549939 0.9791184842694918 0.7987677382128067 0.6739329164331492 0.7756205797308521 0.7300311630305342 1.0 16.979298090695195 -6.8152078579063815 5.613012874978185 0.7717368686297397 0.9566228627879153 0.47179448802715485 0.08256281382331147 0.14776366145990114 9.846047488083837 0.027682983735999103 0.024710516149369012 1.5303548424545077e-07 6.8152078579063815 0.18488599415817564 SRS(ph)APDGGDEENQEQLQDQIAEGSSIEEEEKTDNATLLR ddPTM_A459_Selumetinib_30min_R1 1 SRSAPDGGDEENQEQLQDQIAEGSSIEEEEKTDNATLLR 39 2 H0Y9T6;Q8IZQ1-2;Q8IZQ1 H0Y9T6 WDFY3 WD repeat and FYVE domain-containing protein 3 1 S(0.338)RS(0.66)APDGGDEENQEQLQDQIAEGS(0.001)S(0.001)IEEEEKTDNATLLR 47.18899999999999 0.0031726 6312300.0 369.86 193.81 345.39 189.68 353.37 175.18 322.02 291.79 139.76 333.48 True False 378.47701837772007 171.11863510017542 298.48793509146583 156.55594873457758 321.4077458925408 173.41784825071372 297.72977214021046 284.0507813325026 237.16251233346995 376.2854063702763 1.005824334322674 0.4547575648782655 0.7932487681909849 0.41605639252594817 0.8541594769590022 0.4608678553960854 0.791233906762877 0.7548812059242818 0.6302729479231911 1.0 8.555683527637862 -11.293777537352366 0.4789632755058282 1.255815510384007 0.6703212793220005 0.2049479920312386 0.1843675207690764 76.12578703209721 6.710306682276081 22.44333151411642 0.0846997870655454 5.084198084138933e-12 11.293777537352366 -0.5854942310620065 SRS(ph)APPNLWAAQR ddPTM_A459_Selumetinib_30min_R1 3 SRSAPPNLWAAQR 13 1 Q92934;F5H3B1;F5H1R6 Q92934 BAD Bcl2-associated agonist of cell death 1 S(0.228)RS(0.772)APPNLWAAQR;S(0.024)RS(0.976)APPNLWAAQR;S(0.053)RS(0.947)APPNLWAAQR 137.09 0.0050287 37231600.0 3402.9 2964.0299999999997 4842.1 4574.5 3368.0 3528.83 3630.41 3123.07 2065.34 2885.2000000000003 True False 3482.1809491092404 2616.9999896598356 4184.569415751434 3775.6494490000246 3063.3649946686937 3493.3331741212824 3356.565250840139 3040.2360384389417 3504.731133534695 3255.5435242279036 1.069615848534873 0.8038596228814028 1.2853673694145622 1.159760089490885 0.9409688341964995 1.0730414593212276 1.031030679166298 0.9338643503959834 1.0765425519432703 1.0 11.668682711078233 -7.528510229854228 24.729263317015796 0.9996115764123961 1.0538278275344248 0.03445987695253283 0.12284669639261848 572.4685438869019 2513791.2429120825 0.058950110344330925 0.03417536397807201 2.961350209643325e-08 7.528510229854228 0.05421625112202877 SRS(ph)APPNLWAAQR ddPTM_A459_Selumetinib_30min_R2 1 SRSAPPNLWAAQR 13 1 Q92934;F5H3B1;F5H1R6 Q92934 BAD Bcl2-associated agonist of cell death 1 S(0.119)RS(0.881)APPNLWAAQR 128.74 0.00098751 12719000.0 9009.3 11208.0 11006.0 11706.0 9639.7 7287.7 6284.0 6152.0 4898.5 7602.9 True False 8508.599173085413 12067.617560599843 10297.88594242675 10111.62260602366 8428.674705988586 8291.514523846163 6576.21845150977 6169.901301481575 5878.336875525698 7383.38452229347 1.1523982189190416 1.6344289700966745 1.3947378619294721 1.369510496912699 1.1415733097116851 1.1229964386672096 0.890678039543175 0.8356467529020206 0.7961574881785698 1.0 12.850066579839233 -6.733406110626201 1.1390036850056438 0.8554321803178043 1.4208666602854247 0.7573959450526311 0.1260297773586266 0.21204816123448683 0.5841626082109376 0.06299169535566579 0.05842522624339502 1.8475401682554813e-07 6.733406110626201 0.5654344799676204 SRS(ph)AVTLPR ddPTM_A459_Selumetinib_30min_R1 1 SRSAVTLPR 9 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 S(0.001)RS(0.986)AVT(0.012)LPR 71.085 0.039289 3328000.0 1319.5 1471.2 2046.3 2046.8 1172.7 1109.4 1125.3 981.18 567.57 733.66 True False 1350.241782699945 1298.951220057676 1768.4236995213146 1689.364803194503 1066.6294920570012 1098.2404432546061 1040.4177150157725 955.1559190781885 963.1248363273296 827.8324074535715 1.6310569271542712 1.5690992625588012 2.136209797537427 2.040708708651576 1.2884606623917687 1.326645868615865 1.256797518009856 1.1538034878536183 1.163429732462299 1.0 9.693194917151088 -6.3504221799209315 5.530670401369734 1.2079433373645445 1.843884051081244 0.7625606233936667 0.1768583657044244 0.1228645079375169 5.9617222685480264 0.060566994839160386 0.06896394991361543 4.462495796986867e-07 6.3504221799209315 0.6359407137166995 SRS(ph)AVTLPR ddPTM_A459_Selumetinib_30min_R2 1 SRSAVTLPR 9 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 S(0.001)RS(0.997)AVT(0.002)LPR 103.44 0.00838 1365400.0 6005.8 5272.6 6095.2 7457.0 8677.6 4436.2 4116.5 4629.5 3428.3 5046.4 True False 5672.021679122278 5676.991465918879 5703.041467951982 6441.343735957491 7587.442309271716 5047.246282185917 4307.925406690002 4642.971078545016 4114.055794705471 4900.69731987817 1.157390736235733 1.158404834122669 1.1637204046084115 1.3143728974711748 1.5482372842116963 1.0299036958910555 0.8790433535277172 0.9474102919419719 0.8394837563254663 1.0 12.25877132947228 -6.987296701062523 24.99501064404213 0.9181549395440465 1.2620509416920458 0.6816566934572594 0.1145769345200822 143.4037335955596 282160.0562227583 0.0433682854778751 0.038225005366903236 1.0296824222285636e-07 6.987296701062523 0.3438960021479993 SRS(ph)DIDVNAAAGAK ddPTM_A459_Selumetinib_30min_R1 6 SRSDIDVNAAAGAK 14 1 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 SRS(1)DIDVNAAAGAK;S(0.004)RS(0.996)DIDVNAAAGAK;S(0.032)RS(0.968)DIDVNAAAGAK;S(0.018)RS(0.982)DIDVNAAAGAK;S(0.022)RS(0.978)DIDVNAAAGAK;S(0.399)RS(0.601)DIDVNAAAGAK 170.0 0.00079455 423022100.0 25412.600000000002 27234.0 30523.2 31314.399999999998 30543.300000000003 25077.2 28866.299999999996 26145.9 14512.849999999999 24009.94 True False 26004.66413568823 24045.430619256895 26378.31709193616 25845.92788408929 27780.66390785759 24824.946136275816 26688.89175060855 25452.42579814756 24627.246473374344 27091.849675620575 0.9598703834197528 0.8875521940052291 0.973662463352345 0.9540111950107096 1.0254251459566035 0.9163252577255845 0.985126230588285 0.9394864545203682 0.9090278725241828 1.0 14.725571275368722 -5.287679013431021 24.962999464360188 0.9617702918219025 0.9237112678899536 0.14673154106959818 0.037708252712262295 1217.3572649872935 1158127.1897969188 0.009554721721571242 0.01989744475473613 5.156095902613579e-06 5.287679013431021 -0.03805902393194893 SRS(ph)DIDVNAAAGAK ddPTM_A459_Selumetinib_30min_R2 5 SRSDIDVNAAAGAK 14 1 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 S(0.088)RS(0.912)DIDVNAAAGAK;S(0.035)RS(0.965)DIDVNAAAGAK;S(0.001)RS(0.999)DIDVNAAAGAK;S(0.003)RS(0.997)DIDVNAAAGAK;S(0.004)RS(0.996)DIDVNAAAGAK 194.67 0.00032888 513781000.0 656104.0 536765.0 644285.0 725090.0 736207.0 549506.0 599718.0 616970.0 522520.0 604683.0 True False 619640.3662724105 577933.1495284957 602832.4045444686 626331.4911499823 643718.0948859132 625195.4635811863 627606.0753186733 618765.2805551187 627038.6004286393 587224.2306348879 1.055202312756194 0.9841779670836351 1.0265795808403642 1.0665968100001815 1.0962049270173098 1.064662237975509 1.068767333800456 1.0537121056570327 1.0678009654858849 1.0 19.16355197377522 -5.695324333717526 4.873331237041698 1.0640506066475222 1.0167489043570936 0.2654373211666703 0.02802195660333243 0.21406634528121338 9.755380885649428 0.007306942526766946 0.012756632072921364 2.0168595983057428e-06 5.695324333717526 -0.047301702290428516 SRS(ph)DIDVNAAASAK ddPTM_A459_Selumetinib_30min_R1 5 SRSDIDVNAAASAK 14 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.028)RS(0.972)DIDVNAAASAK;S(0.139)RS(0.861)DIDVNAAASAK;S(0.009)RS(0.991)DIDVNAAASAK;S(0.084)RS(0.916)DIDVNAAASAK;S(0.02)RS(0.98)DIDVNAAASAK 221.51 3.4306e-09 489350800.0 13127.04 15203.0 15900.53 16599.899999999998 15660.5 12682.03 13759.6 13335.080000000002 8011.15 12089.74 True False 13432.874491226587 13423.02569231705 13741.32536135936 13701.039083715285 14244.010540085841 12554.460292561927 12721.702294082483 12981.390359955534 13594.336438754133 13641.575893040022 0.9847010782735215 0.9839791089800352 1.0073121660650828 1.004358967845174 1.044161660776537 0.9203086498948596 0.9325683772776676 0.951604892406799 0.9965370969852544 1.0 13.735722695593937 -6.765168701582447 24.999999463504665 0.955451899880371 1.0038438423462046 0.3833271580823624 0.02800876986421666 99.28349829664698 665554.5830602014 0.009949155503915378 0.009111392775831183 1.7172411956695228e-07 6.765168701582447 0.04839194246583356 SRS(ph)DIDVNAAASAK ddPTM_A459_Selumetinib_30min_R2 4 SRSDIDVNAAASAK 14 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.004)RS(0.996)DIDVNAAASAK;S(0.017)RS(0.983)DIDVNAAASAK;S(0.002)RS(0.998)DIDVNAAASAK;S(0.06)RS(0.94)DIDVNAAASAK 196.01 9.6678e-06 251195000.0 373440.0 310742.0 343310.0 398036.0 414462.0 277916.8 328862.3 330597.6 288478.2 311882.0 True False 352685.69979876495 334574.91220698704 321221.80836766586 343822.810149602 362393.57822270814 316197.3165224761 344155.04857828474 331559.5842826209 346181.90075436886 302877.15629324794 1.1644513046645617 1.1046554857476576 1.0605679619385242 1.1351889801048918 1.1965035021387878 1.0439787549257478 1.1362859212963266 1.0946998721871333 1.1429779155057602 1.0 18.208373245223633 -11.267029689167664 2.7320496782684494 0.976416190418442 1.1179355759840486 0.4035861365081156 0.04367502650435131 16735165.81813423 13938415.26589275 2675601.9741704473 0.010597557319215994 5.407173572513769e-12 11.267029689167664 0.14151938556560661 SRS(ph)DITQVDWR ddPTM_A459_Selumetinib_30min_R2 1 SRSDITQVDWR 11 1 C9J119;Q6ZWE6-3;Q6ZWE6-2;Q6ZWE6 C9J119 PLEKHM3 Pleckstrin homology domain-containing family M member 3 1 S(0.351)RS(0.649)DITQVDWR 83.85600000000002 0.02051 6985500.0 32079.0 31451.0 36726.0 40128.0 36304.0 32039.0 27777.0 31176.0 26620.0 30026.0 True False 30296.177602411626 33863.1905690958 34363.08914424541 34662.49717533893 31743.1669581221 36452.08142891543 29068.6855390813 31266.71699853535 31944.743824945213 29159.07136308297 1.038996654768927 1.1613260980584077 1.1784699422132838 1.188738034340271 1.088620640995815 1.2501111909573985 0.9969002502557024 1.0722809587866635 1.0955336480773206 1.0 14.831657154042547 -7.278781479170671 24.99120867383312 1.0472021294071674 1.1516337520343412 0.4427873853130756 0.06022427937767274 820.5801558951983 1182509.6834870006 0.024532762783365324 0.01658181202020299 5.262820053112836e-08 7.278781479170671 0.10443162262717376 SRS(ph)DNALHLASER ddPTM_A459_Selumetinib_30min_R2 1 SRSDNALHLASER 13 1 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 S(0.072)RS(0.928)DNALHLASER 67.902 0.037672 6255300.0 13463.0 10170.0 17772.0 20167.0 16428.0 15374.0 11170.0 17264.0 19334.0 13520.0 True False 12714.780356659112 10950.006298295897 16628.568868690545 17420.21980998454 14364.167771816614 17491.628948723308 11689.427132935107 17314.235381790935 23201.340237095825 13129.642470821358 0.9684026343379711 0.8339912014078547 1.2664906074666558 1.3267855426146098 1.0940258124879487 1.3322243151400204 0.8903081069353631 1.3187133937781779 1.7670961177090152 1.0 13.68054001073868 -5.266557451762237 24.072015799179468 1.248178188908561 0.9011969008994183 0.2754977210429399 0.22589573951495745 301.0610314241527 1416004.0644752563 0.05897270257652417 0.12925085890183072 5.413056351382533e-06 5.266557451762237 -0.34698128800914274 SRS(ph)DVDMDAAAEATR ddPTM_A459_Selumetinib_30min_R1 2 SRSDVDMDAAAEATR 15 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 SRS(1)DVDMDAAAEATR;S(0.024)RS(0.976)DVDMDAAAEATR 274.16 1.1816999999999995e-44 36640000.0 5448.2 6034.4 6566.299999999999 7061.200000000001 6555.2 5303.2 5769.6 5236.5 3260.9 3710.9 True False 5575.132459648228 5327.889642683548 5674.632526104096 5828.093975140229 5962.283317414557 5249.85462292034 5334.394426868389 5097.611009450798 5533.509133287151 4187.230162226992 1.331460713562274 1.272413847881219 1.355223454706398 1.3918733266003553 1.423920607756488 1.2537774183705697 1.2739673292836793 1.2174183916223071 1.321520174172641 1.0 12.031780506484559 -10.148571753498922 0.34427338213414066 0.884431788097307 1.3499855488085513 0.7485285775485793 0.05633101678391472 5.154153244176905 0.5825210149293784 0.7169250649161044 0.052926877587323604 7.10277809247637e-11 10.148571753498922 0.4655537607112442 SRS(ph)DVDMDAAAEATR ddPTM_A459_Selumetinib_30min_R2 1 SRSDVDMDAAAEATR 15 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 S(0.017)RS(0.983)DVDMDAAAEATR 132.87 0.0027839 18285000.0 40282.0 40509.0 29395.0 48914.0 55411.0 24635.0 31239.0 30601.0 24813.0 35772.0 True False 38043.28770162241 43615.91004303525 27503.757702856125 42251.828818643546 48449.77479937483 28028.247635735577 32691.67539890415 30690.04384373174 29776.293333146714 34739.16941318207 1.0951121844377363 1.2555254135260017 0.7917217989794423 1.2162590393600698 1.3946728035757283 0.806819740056883 0.9410609393124701 0.883442073087854 0.8571388964137941 1.0 15.084275640281458 -6.790291049087128 24.99982836762987 0.8931179553375482 1.1401880296321882 0.4093720422033311 0.15161484917122509 229.3727266689304 198748.7019148677 0.05456364210963357 0.04812868309315039 1.6207235806393227e-07 6.790291049087128 0.24707007429464 SRS(ph)DVDMDPSSATAVLGPAR ddPTM_A459_Selumetinib_30min_R1 2 SRSDVDMDPSSATAVLGPAR 20 1 M0QZR4;M0QYC1;M0QZH8;M0QYS3 M0QZR4 ARHGEF1 1 S(0.076)RS(0.924)DVDMDPSSATAVLGPAR;S(0.148)RS(0.852)DVDMDPSSATAVLGPAR 149.74 8.618e-06 45734000.0 5036.0 4893.3 5582.299999999999 5468.5 5432.6 5074.6 4556.7 4941.7 2778.6000000000004 3571.1 True False 5153.329001649806 4320.390161166548 4824.254321378991 4513.529131458441 4941.22228920343 5023.554131368145 4212.984450379782 4810.630063096158 4715.081259085431 4029.4854704596805 1.2789049717213443 1.0721940041326619 1.1972382967368398 1.1201254265705396 1.2262663125174984 1.2466986587235571 1.0455390598291867 1.1938571557989424 1.1701447476735878 1.0 11.976379915820456 -13.704310383946247 0.34763942000211423 2.473789243514814e-12 1.1749578148866668 0.35350167988519876 0.07029953491636315 256.3205594857134 3.7042637210646783 187.03540507763677 0.052621307506263974 1.975557233452825e-14 13.704310383946247 1.174957814884193 SRS(ph)DVDMDPSSATAVLGPAR ddPTM_A459_Selumetinib_30min_R2 4 SRSDVDMDPSSATAVLGPAR 20 1 M0QZR4;M0QYC1;M0QZH8;M0QYS3 M0QZR4 ARHGEF1 1 S(0.095)RS(0.904)DVDMDPSS(0.001)ATAVLGPAR;S(0.157)RS(0.843)DVDMDPSSATAVLGPAR;S(0.161)RS(0.839)DVDMDPSSATAVLGPAR;S(0.202)RS(0.798)DVDMDPSSATAVLGPAR 140.27 0.00021539 60987400.0 182102.0 156965.0 190873.0 220423.0 212155.0 149933.0 153430.0 161130.0 139269.0 202457.0 True False 171981.4998520641 169003.71077797603 178592.4389868087 190401.00714911593 185502.19221023566 170584.909793738 160564.79901577716 161598.86162349244 167126.6915009881 196611.5403635418 0.8747273915562847 0.8595818458340853 0.9083517613288867 0.9684121633809369 0.9434959507831302 0.8676240950979804 0.8166600939033745 0.8219195135986949 0.8500350040082328 1.0 17.584988479414484 -6.922841649902337 7.4604302367779045 0.8551981090505972 0.9109122746104503 0.080549258798285 0.05648892151008977 0.4175850943493851 34.31546890738176 0.02008391724622349 0.017699990025552108 1.1944235293050616e-07 6.922841649902337 0.05571416555985309 SRS(ph)ESDVSSVEQDSFIEPYATTSQLRPR ddPTM_A459_Selumetinib_30min_R2 1 SRSESDVSSVEQDSFIEPYATTSQLRPR 28 2 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 S(0.141)RS(0.421)ES(0.421)DVS(0.012)S(0.004)VEQDSFIEPYATTSQLRPR 71.143 0.00015743 5463200.0 3804.4 1910.6 1461.5 1510.8 3475.9 3323.0 1173.9 1488.4 3511.8 3324.3 True False 3592.9666782198537 2057.136876452719 1367.468681160885 1305.0264337246326 3039.226367059735 3780.7130868093896 1228.4886760387215 1492.7309975821152 4214.258127890406 3228.3188214313177 1.1129528640008561 0.6372161456905487 0.42358538818498714 0.40424335572470876 0.9414269578592159 1.1711089566838881 0.380535115640795 0.462386486635881 1.3054033263114824 1.0 11.656567347597711 -6.284544724025274 24.798565378336484 0.8398306490759819 0.6281995689128731 0.10338011629906319 0.32295297086915004 1969.9509338817684 2114307.7601125906 0.1049054667366927 0.11903036307820292 5.193441882347185e-07 6.284544724025274 -0.21163108016310883 SRS(ph)ESETSTMAAK ddPTM_A459_Selumetinib_30min_R1 2 SRSESETSTMAAK 13 1 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 S(0.084)RS(0.875)ES(0.04)ETSTMAAK;S(0.031)RS(0.953)ES(0.002)ET(0.002)S(0.002)T(0.01)MAAK 138.98 0.00052732 99976000.0 6589.58 7768.24 7509.35 8014.11 7159.83 6510.92 6880.68 6275.67 3639.4 5458.16 True False 6743.104392909358 6858.730849443202 6489.621515906945 6614.596131976305 6512.224640670653 6445.42605624236 6361.664767932754 6109.218845350924 6175.795988740918 6158.768002980648 1.0948787792698003 1.1136530627755088 1.0537207299846616 1.0740128754281781 1.0573908024330423 1.0465447071756848 1.0329443753773337 0.9919546965227878 1.002764836368577 1.0 12.588426068414556 -6.7057892482263 0.4987647136509018 0.990022646178883 1.1065110601741197 0.8685993796453013 0.014044357896455976 0.3668508135007685 0.19354087677439977 0.012989417623647683 0.018299467553010703 1.9688414852935317e-07 6.7057892482263 0.11648841399523668 SRS(ph)ESETSTMAAK ddPTM_A459_Selumetinib_30min_R2 3 SRSESETSTMAAK 13 1 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 S(0.26)RS(0.738)ES(0.002)ETSTMAAK;S(0.029)RS(0.939)ES(0.022)ET(0.004)S(0.005)T(0.001)MAAK;SRS(0.673)ES(0.318)ET(0.008)S(0.001)TMAAK 166.9 0.0015187000000000002 95118900.0 220759.0 210680.0 234742.0 244576.0 252709.0 187947.0 192158.0 203144.0 180006.0 238034.0 True False 208490.0985482961 226838.4785570283 219638.95528776536 211264.32688286717 220961.43617287558 213834.99323700398 201093.72775385366 203735.11540770018 216012.2297878695 231161.33993339457 0.9019245978084796 0.9812993756758296 0.9501543612398631 0.9139258621002093 0.9558753909132992 0.9250465207487424 0.8699280243478239 0.8813546221284372 0.9344652088022588 1.0 17.818540612110745 -6.998622630425431 24.21742539885964 0.9095409128486603 0.94179202036509 0.01860100852239499 0.03919534443049588 64.10040536865328 1127001.1355357643 0.013387376148004355 0.011705788325919843 1.0031765452108281e-07 6.998622630425431 0.03225110751642968 SRS(ph)FDYNYR ddPTM_A459_Selumetinib_30min_R1 1 SRSFDYNYR 9 1 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.001)RS(0.999)FDYNYR 152.67 0.0051369 49311000.0 3830.3 4785.1 4096.3 4546.6 4567.6 3773.8 4188.2 3808.0 2244.7 3824.9 True False 3919.5385375336073 4224.85826746736 3540.044959365276 3752.621660252164 4154.4613864752755 3735.8389983362445 3872.280702060835 3706.9994698727464 3809.091953598596 4315.863172681029 0.9081702502396007 0.9789138576519939 0.8202403129398071 0.8694950488713067 0.9626026637666805 0.865606449709463 0.897220450956827 0.8589242340530332 0.8825794056006587 1.0 12.075433411947788 -11.099426686791892 6.4652193047958635 1.000194539470146 0.8936547364505066 0.33316653478190394 0.04509467165021101 0.0001275930709539284 8.356942622926865e-06 0.044057498905428254 0.010666090341484039 7.953775218011878e-12 11.099426686791892 -0.10653980301963928 SRS(ph)FDYNYR ddPTM_A459_Selumetinib_30min_R2 2 SRSFDYNYR 9 1 O75494-2;O75494;Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3 O75494-2;O75494-6 SRSF10 Serine/arginine-rich splicing factor 10 1 S(0.038)RS(0.961)FDYNYR;S(0.085)RS(0.915)FDYNYR 68.515 0.043488 31308200.0 57842.0 53053.0 63960.0 73742.0 77404.0 44439.0 40031.0 50250.0 45882.0 64886.0 True False 54627.37319987194 57121.99450771807 59844.88323438259 63698.212387954554 67679.81751946015 50560.068872922784 41892.52081992164 50396.21918066466 55059.682050192896 63012.572585925634 0.866928153510644 0.9065174165016828 0.9497292489173729 1.0108809999955797 1.0740684714494102 0.8023806487820778 0.6648279716368647 0.7997803789385527 0.8737888296039975 1.0 15.943352090665377 -6.7927851323383255 24.648790224452974 0.8054337198228866 0.960638915694728 0.3189808485160275 0.09463621250887827 184.74433543144505 145272.63713191316 0.034202772217392846 0.030167128429895156 1.6114427009956235e-07 6.7927851323383255 0.15520519587184145 SRS(ph)FSGLIK ddPTM_A459_Selumetinib_30min_R2 1 SRSFSGLIK 9 1 Q14CB8-4;Q14CB8-6;Q14CB8-7;Q14CB8-3;Q14CB8;Q14CB8-2 Q14CB8-4 ARHGAP19 Rho GTPase-activating protein 19 1 S(0.005)RS(0.993)FS(0.002)GLIK 84.29700000000003 0.020173 3019900.0 19349.0 22917.0 22431.0 25384.0 24466.0 16335.0 18071.0 12135.0 13621.0 24696.0 True False 18273.660040184004 24674.660210230802 20987.813881026203 21926.655410157564 21392.36235118488 18584.997975633865 18911.337307007183 12170.310840942611 16345.580602538645 23982.962312086114 0.7619434080907957 1.0288412202439274 0.875113491315853 0.9142596783845888 0.8919816523417662 0.7749250377743384 0.7885321696676684 0.5074565302889807 0.6815496930627856 1.0 14.549722247184258 -6.981643645660399 1.8869483715653104 0.7005084179529296 0.9044957332525837 0.21083054928124656 0.13065189733099639 0.40604718874673584 2.9183582321332335 0.05664230664847254 0.04417054437424576 1.0431730395473288e-07 6.981643645660399 0.20398731529965408 SRS(ph)FSSSAEEHS ddPTM_A459_Selumetinib_30min_R1 1 SRSFSSSAEEHS 12 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 S(0.047)RS(0.929)FS(0.002)S(0.002)S(0.019)AEEHS 109.15 0.036849 4794700.0 1298.2 1519.6 1443.6 1817.7 1815.6 1472.1 1329.2 1526.8 640.32 1106.0 True False 1328.4455341425298 1341.6845255571254 1247.56704912719 1500.2728174548797 1651.379300570214 1457.292010559857 1228.93737385494 1486.3043042546508 1086.5762728775574 1247.9658733523022 1.064488671131721 1.0750971274182963 0.9996804205678792 1.2021745542006108 1.3232567779551994 1.1677338633028964 0.984752387942911 1.190981529216116 0.8706778735533705 1.0 10.285362767725577 -8.261514870427023 24.999999994182094 0.9353389278072276 1.1259063720554576 0.3647417682601365 0.10065863370552137 7.918088739633497 2619625.8498288007 0.08523333274330895 0.027320035566088807 5.476273496484483e-09 8.261514870427023 0.19056744424823002 SRS(ph)FTLDDESLK ddPTM_A459_Selumetinib_30min_R1 2 SRSFTLDDESLK 12 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 S(0.028)RS(0.971)FTLDDESLK;S(0.026)RS(0.973)FT(0.001)LDDESLK 167.18 0.000242 183989000.0 18489.2 19083.1 23436.0 24302.0 19072.8 18621.5 19391.6 20201.5 13920.400000000001 12432.3 True False 18919.96238627951 16848.841780507493 20253.5199247332 20058.111905038517 17347.668607576332 18434.184616969218 17928.875999733267 19665.690596280012 23621.90209421033 14028.10680585697 1.348718159059076 1.2010773808389326 1.4437814171957268 1.4298516672730148 1.236636479010367 1.3140892689291925 1.2780681133855967 1.4018777350675184 1.6838980784169528 1.0 13.77603269954805 -7.8272530437836 9.350998240264106 1.4077201155311727 1.3224336652343038 0.0 0.1713524411411176 1.2327940426764192 163.1679716151812 0.08885782204100633 0.04265439028976055 1.488493547024556e-08 7.8272530437836 -0.08528645029686888 SRS(ph)FTLDDESLK ddPTM_A459_Selumetinib_30min_R2 3 SRSFTLDDESLK 12 1 Q86WR7;Q86WR7-2;X6RHS9 Q86WR7 PROSER2 Proline and serine-rich protein 2 1 S(0.01)RS(0.989)FT(0.001)LDDESLK;S(0.251)RS(0.728)FT(0.019)LDDES(0.002)LK;S(0.081)RS(0.884)FT(0.035)LDDESLK 158.14 0.00024817 91933000.0 516530.0 545070.0 505190.0 535850.0 544650.0 423930.0 504810.0 506030.0 476610.0 825830.0 True False 487823.3304334198 586875.1163237103 472686.6254092841 462866.30560719117 476226.19776722114 482322.50944661605 528284.6652620381 507502.4635222234 571945.3175960601 801986.142135978 0.6082690271108308 0.7317771286678976 0.5893950039465138 0.5771500045803927 0.5938085120758562 0.6014100295573904 0.6587204410478038 0.6328070235360446 0.7131610978623193 1.0 19.613217782383302 -8.947641724463022 1.1691782406513445 1.0003771697185695 0.6205958646598351 0.8782176925131345 0.042097850699396304 0.5220230101975605 1.066757901630836 0.04260738362163595 0.013040006214484508 1.1281277325558201e-09 8.947641724463022 -0.3797813050587344 SRS(ph)GEGEVSGLMR ddPTM_A459_Selumetinib_30min_R1 2 SRSGEGEVSGLMR 13 1 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 S(0.022)RS(0.978)GEGEVSGLMR;S(0.002)RS(0.998)GEGEVSGLMR 164.93 0.001721 171483000.0 5245.9 6015.299999999999 6615.299999999999 7127.4 6374.700000000001 5289.1 6170.3 5108.5 2995.7 3746.5 True False 5368.119263255502 5311.025879562899 5716.978595241824 5882.733387868135 5798.109510544698 5235.896456118562 5704.869303262971 4973.005985253398 5083.484102728791 4227.3997690003625 1.2698395128419286 1.2563339569890684 1.352362896257076 1.3915725290535281 1.3715545790257153 1.2385619393068839 1.3494984186489607 1.1763746645681787 1.202508487606523 1.0 12.045554833624877 -8.52985554657173 0.8205870996074708 1.0026441418768939 1.3247729405160802 0.7541745278380212 0.055379219832529795 0.3386716111670831 0.5093058891643562 0.055435301670125156 0.020143825301401026 2.9521910102606385e-09 8.52985554657173 0.3221287986391863 SRS(ph)GSSQELDVKPSASPQER ddPTM_A459_Selumetinib_30min_R1 2 SRSGSSQELDVKPSASPQER 20 2 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.278)RS(0.687)GS(0.027)S(0.007)QELDVKPS(0.001)ASPQER;S(0.27)RS(0.696)GS(0.024)S(0.01)QELDVKPSASPQER 68.959 0.014355 9858100.0 974.27 808.51 1088.8400000000001 1480.12 1222.5900000000001 1011.5699999999999 956.02 855.98 513.77 883.45 True False 996.9685954005867 713.8492733338986 940.9815085699988 1221.644827293457 1112.0069503657953 1001.3945242320732 883.9066417038819 833.2766297851034 871.8301657238609 996.8494130317281 1.0001195590500436 0.7161054257561948 0.9439555225379351 1.2255058901806004 1.1155214978597796 1.0045594762267271 0.886700268013047 0.8359102376866039 0.8745856237928205 1.0 9.961231773153651 -7.2631349754225365 21.298136410654138 0.8856248405857632 1.0008359423228368 0.12817580081261737 0.12791670349821854 43.23399613594321 543013.174228461 0.05799400573291525 0.04149581362036896 5.455882700532343e-08 7.2631349754225365 0.1152111017370736 SRS(ph)GSSQELDVKPSASPQER ddPTM_A459_Selumetinib_30min_R2 1 SRSGSSQELDVKPSASPQER 20 2 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.249)RS(0.713)GS(0.018)S(0.02)QELDVKPSASPQER 69.28399999999999 0.013921 4586900.0 11910.0 14431.0 13066.0 15633.0 13764.0 11012.0 8134.0 9089.3 9054.1 14276.0 True False 11248.089879507543 15537.811297021452 12225.34778518516 13503.758431570812 12034.843268278788 12528.803043016842 8512.247117215227 9115.74835818538 10865.17299269108 13863.814786497467 0.8113271889972531 1.1207457353047126 0.8818170159840799 0.9740290561817568 0.8680758834141388 0.9037053102598538 0.6139902507573638 0.6575209275778537 0.7837073100019422 1.0 13.759036665618156 -7.107802968179596 6.275137646050919 0.7357618718509435 0.9361896982368839 0.2860797762254754 0.123235953117083 0.25337833317372416 12.705515788924275 0.04536843682396155 0.03512109514908788 7.801839860902393e-08 7.107802968179596 0.20042782638594037 SRS(ph)HGIFPDPSK ddPTM_A459_Selumetinib_30min_R2 1 SRSHGIFPDPSK 12 1 Q9Y6V0-6;Q9Y6V0;Q9Y6V0-3 Q9Y6V0-6 PCLO Protein piccolo 1 S(0.326)RS(0.671)HGIFPDPS(0.002)K 78.548 0.024054 131860000.0 42383.0 44140.0 41390.0 46994.0 42478.0 28452.0 28005.0 25685.0 23433.0 46786.0 True False 40027.52253259176 47525.39606753008 38727.012462024635 40593.33613082828 37141.53388186181 32371.004738459455 29307.28799085473 25759.739097619342 28120.25477272505 45435.16661537335 0.8809810883151495 1.0460046613199714 0.8523576636103066 0.8934342967082506 0.8174622577326408 0.7124658529920844 0.6450353365918631 0.5669559730172383 0.6189094674346443 1.0 15.471521748922921 -6.49911897891993 1.4541182607843859 0.6707185588699274 0.936341813162455 0.39057907677047266 0.12031172044086025 0.347228336812638 1.5018812057243127 0.047201222777850035 0.05334824441942839 3.1686992501666595e-07 6.49911897891993 0.26562325429252764 SRS(ph)PAPPADK ddPTM_A459_Selumetinib_30min_R2 2 SRSPAPPADK 10 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 S(0.054)RS(0.946)PAPPADK;S(0.293)RS(0.707)PAPPADK 71.031 0.039755 83078000.0 94916.0 73752.0 79189.0 90852.0 98690.0 73122.0 109001.0 113707.0 97796.0 89534.0 True False 89640.94869885282 79408.54124994278 74094.06595446392 78477.80087155837 86291.6799002058 83193.89176457305 114069.762481384 114037.86854479293 117357.93264854775 86948.92078273073 1.030961027369724 0.913278054921119 0.8521562463047849 0.9025736048830311 0.9924410691172665 0.9568133913065949 1.3119169445061112 1.3115501321718814 1.3497342070731795 1.0 16.407880500341058 -7.246764388803498 11.422557990942325 1.2692761427532147 0.9365409191977779 0.6752545570383488 0.10190921974431055 0.3763112026664574 291.2381612254405 0.038219567618634945 0.028905877896869124 5.665465655927179e-08 7.246764388803498 -0.3327352235554367 SRS(ph)PAPPADKEAFAAEAQK ddPTM_A459_Selumetinib_30min_R2 3 SRSPAPPADKEAFAAEAQK 19 2 Q9Y618;Q9Y618-4;Q9Y618-5 Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 S(0.263)RS(0.737)PAPPADKEAFAAEAQK;S(0.414)RS(0.586)PAPPADKEAFAAEAQK;S(0.439)RS(0.561)PAPPADKEAFAAEAQK 74.812 0.0037808 26780400.0 127247.0 119902.0 124746.0 127191.0 138272.0 100858.0 107705.0 113421.0 85507.0 128360.0 True False 120175.12115010043 129098.09785430417 116719.97817317501 109867.36638328686 120901.0351926362 114750.2740022333 112713.49591340868 113751.03633214264 102610.78926519859 124653.91328066771 0.9640701842991247 1.035652186575403 0.9363522981454353 0.881379200153245 0.9698936199493263 0.9205509155887018 0.9042114519070551 0.9125348201145004 0.8231654070431198 1.0 16.9275686487383 -5.434265693158488 5.605489079253567 0.9138543947113013 0.998703099142871 0.32536587195947475 0.04751374619364919 0.23564346721456655 11.571511767542932 0.012058204047269346 0.025462634237311196 3.6790382816876503e-06 5.434265693158488 0.08484870443156978 SRS(ph)PASAEAPGDSGER ddPTM_A459_Selumetinib_30min_R1 1 SRSPASAEAPGDSGER 16 1 H7BY64;Q8NB15;Q8NB15-1 H7BY64 PRAP1;ZNF511 Zinc finger protein 511 1 S(0.362)RS(0.638)PASAEAPGDSGER 147.64 0.00017133 6700000.0 911.4 944.98 876.74 823.83 990.08 804.77 1047.5 890.24 500.23 783.22 True False 932.6338467243112 834.3413022907167 757.6835235880941 679.9635557043811 900.5274388128208 796.6747444726957 968.4862316529114 866.6279432929397 848.8537746463346 883.7539162088511 1.0553094358270527 0.9440878133472881 0.8573467225338284 0.7694037256675537 1.0189798566052473 0.9014667203855686 1.0958777255636354 0.9806213329278597 0.9605092085902918 1.0 9.787500892774634 -6.816945857192542 2.013464269586364 1.0028638731225705 0.9111035629394395 0.15718223125045838 0.08392405779954894 0.5863332400418602 4.887507694648284 0.03575727183407137 0.03160742897052715 1.5242427668922238e-07 6.816945857192542 -0.09176031018313102 SRS(ph)PASAEAPGDSGER ddPTM_A459_Selumetinib_30min_R2 2 SRSPASAEAPGDSGER 16 1 H7BY64;Q8NB15;Q8NB15-1 H7BY64 PRAP1;ZNF511 Zinc finger protein 511 1 S(0.258)RS(0.742)PASAEAPGDSGER;S(0.05)RS(0.943)PAS(0.007)AEAPGDSGER 159.4 0.00029354 5303300.0 10835.7 10085.4 10189.0 10855.3 13740.6 6418.9 9697.6 8844.599999999999 8367.7 12381.400000000001 True False 10233.4951727439 10858.917750327775 9533.450832944412 9376.789413563009 12014.382985477432 7303.045210027323 10148.55761542985 8870.336321697641 10041.473813072658 12023.916811259429 0.8510949745727663 0.9031098535345217 0.7928739846251351 0.7798448343207433 0.9992070948317715 0.6073765582932684 0.8440309239270971 0.7377243589535888 0.8351250237917172 1.0 13.553619312512618 -5.264791312203925 24.792968863654426 0.812740432130028 0.8771024140361342 0.02644713038259383 0.11042981057294646 778.8576246624532 5760971.398286777 0.02723417173302355 0.06056691193142383 5.435114376353208e-06 5.264791312203925 0.0643619819061062 SRS(ph)PESQVIGENTK ddPTM_A459_Selumetinib_30min_R1 1 SRSPESQVIGENTK 14 1 O95218-2 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 S(0.007)RS(0.683)PES(0.31)QVIGENTK 147.83 0.0022362 6223100.0 1246.7 1955.4 1211.4 1637.3 1516.8 1370.9 1319.4 1319.5 737.24 1341.6 True False 1275.7456843440846 1726.4608589592035 1046.898533743889 1351.3762909274778 1379.6057078127901 1357.1099906776094 1219.8765957449655 1284.5025736599512 1251.0424341208316 1513.807428290639 0.8427397438422078 1.1404758800190908 0.6915665190823022 0.8927002640312214 0.9113482217289772 0.8964878658377511 0.8058334058529661 0.8485244223635404 0.8264211224894592 1.0 10.563965976167852 -5.257375897240027 24.996472975250363 0.8561978462190502 0.9916077862005693 0.21620140085723838 0.10078955775333011 473.080438781447 2910121.7097027884 0.02414591977076817 0.059262438031963516 5.528713723296619e-06 5.257375897240027 0.13540993998151918 SRS(ph)PESQVIGENTK ddPTM_A459_Selumetinib_30min_R2 1 SRSPESQVIGENTK 14 1 O95218-2 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 S(0.061)RS(0.938)PES(0.001)QVIGENTK 131.82 0.0056231 0.0 14341.0 12246.0 9882.5 13306.0 13215.0 10757.0 11260.0 12453.0 7766.9 10413.0 True False 13543.984631571584 13185.228822903791 9246.670709252441 11493.699845869703 11554.813556401052 12238.67910767637 11783.612311266712 12489.236168294867 9320.497025318065 10112.349633776827 1.3393509047919547 1.3038739066994942 0.9143938890687796 1.1366003215987461 1.1426437944556596 1.2102705652895218 1.1652694712915788 1.2350478989154872 0.9216944985946837 1.0 13.303830630118934 -5.0483558860942415 17.854619286184935 1.1095264303416348 1.3304831166518118 0.4165421363635833 0.10783055320350805 13.629261684674264 5032.695232819813 0.02711440790237135 0.0717814280321556 8.946313522574954e-06 5.0483558860942415 0.22095668631017706 SRS(ph)PHEAGFCVYLK ddPTM_A459_Selumetinib_30min_R1 1 SRSPHEAGFCVYLK 14 1 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 S(0.029)RS(0.971)PHEAGFCVYLK 80.361 0.018771 29197000.0 3781.7 3577.5 4151.5 3949.7 4797.6 3645.8 3795.5 3180.4 1391.7 2251.4 True False 3869.806252092746 3158.6446368653724 3587.7491025571708 3259.9590400514585 4363.657927085077 3609.1265621215434 3509.2023792254195 3096.0454606048565 2361.613254253651 2540.3891204931037 1.5233124015826343 1.2433703999851258 1.4122832890501313 1.2832518505742467 1.717712413379438 1.4206983225550076 1.3813641189520853 1.2187288300163626 0.929626581692827 1.0 11.310833781348132 -8.002696633945101 2.2647347704111374 0.9614661315133987 1.4271657669563023 0.6874299024367293 0.12422615417862341 0.18598690180903676 1.7697175815035482 0.10308740809337244 0.035106574362349846 9.938100083027784e-09 8.002696633945101 0.4656996354429036 SRS(ph)PLELEPEAK ddPTM_A459_Selumetinib_30min_R1 5 SRSPLELEPEAK 12 1 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 S(0.043)RS(0.957)PLELEPEAK;S(0.016)RS(0.984)PLELEPEAK;S(0.003)RS(0.997)PLELEPEAK;S(0.014)RS(0.986)PLELEPEAK;S(0.008)RS(0.992)PLELEPEAK 167.29 0.00023958 974440400.0 27291.8 32101.9 32517.7 33346.7 28977.0 28292.5 31101.4 27302.100000000002 15354.3 22761.599999999995 True False 27927.64583940155 28343.39462423159 28101.974946940456 27523.32484008507 26356.035466304857 28007.903137534628 28755.396358119204 26577.959618280664 26055.12566629793 25683.273076759255 1.087386555285791 1.1035740865084471 1.094174206805825 1.0716439745754553 1.026194573703084 1.0905114411947334 1.1196157231275912 1.034835378607994 1.0144783956634857 1.0 14.64854145080667 -7.947878826009067 5.931983244363575 1.0124732146979534 1.0832202493787475 0.6503643678104013 0.02343335147744783 0.12916227981791553 9.889498718969513 0.014603014808359922 0.006785580010560811 1.1275120032780056e-08 7.947878826009067 0.07074703468079413 SRS(ph)PLELEPEAK ddPTM_A459_Selumetinib_30min_R2 5 SRSPLELEPEAK 12 1 A0A087WTQ7;A0A087WV56;A0A087WW71;A0A087X0X5;Q92466-3;Q92466-2;Q92466-5;Q92466-4;Q92466 A0A087WTQ7 DDB2 DNA damage-binding protein 2 1 S(0.058)RS(0.942)PLELEPEAK;SRS(1)PLELEPEAK;S(0.003)RS(0.997)PLELEPEAK;S(0.043)RS(0.957)PLELEPEAK;S(0.315)RS(0.685)PLELEPEAK 154.13 0.00031461 834415800.0 1895696.0 1756844.0 2187582.0 2180838.0 2260677.0 1527548.0 1486375.0 1699516.0 1475328.0 1958086.0 True False 1790340.805392353 1891588.28565618 2046835.3557791945 1883804.1022446128 1976670.5445511944 1737953.871299881 1555494.3826961855 1704461.310189982 1770434.824108518 1901550.969461593 0.9415160751117136 0.9947607589986222 1.0764030986551665 0.9906671619630553 1.0395043710613083 0.9139664932525932 0.8180135098543321 0.8963532072309294 0.9310477881167711 1.0 20.858745179028396 -6.832140382408434 6.267391351720204 0.8982139219410654 1.010413439751314 0.4410747144164885 0.05345771119545253 0.17565473264103126 11.946511779963851 0.018900772435805586 0.01674661918270715 1.4718366654550463e-07 6.832140382408434 0.11219951781024862 SRS(ph)PLGFYVHLK ddPTM_A459_Selumetinib_30min_R1 3 SRSPLGFYVHLK 12 1 Q8IXT5;B9ZVT1 Q8IXT5 RBM12B RNA-binding protein 12B 1 S(0.126)RS(0.874)PLGFYVHLK;S(0.14)RS(0.86)PLGFYVHLK;S(0.031)RS(0.969)PLGFYVHLK 118.08 0.0021092 34560500.0 10969.6 12791.099999999999 11743.4 13539.099999999999 12612.099999999999 9972.1 11162.8 10483.300000000001 6547.53 9090.5 True False 11225.170336874056 11293.512065578943 10148.710781878812 11174.750345383376 11471.337781847109 9871.789727942363 10320.781008778155 10205.24882944248 11110.680197329459 10257.35422396844 1.0943533870210034 1.1010160923554055 0.9894082392284201 1.089437890257436 1.1183525041030506 0.9624109212173716 1.0061835424052632 0.9949201915632196 1.0831916257086107 1.0 13.32437103055277 -6.759620390350577 24.999899972706853 1.0088264134550144 1.075420361174542 0.3928127126614267 0.04291178750790137 55.869653239912935 767865.791088653 0.014897483608190145 0.014163579978042332 1.7393204758671837e-07 6.759620390350577 0.06659394771952765 SRS(ph)PLHPMSEIPR ddPTM_A459_Selumetinib_30min_R1 1 SRSPLHPMSEIPR 13 1 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 S(0.034)RS(0.966)PLHPMSEIPR 79.317 0.021628 27330000.0 2307.0 2537.3 2476.2 2376.7 2763.6 2433.6 2481.1 2695.8 981.37 1925.5 True False 2360.7486113594327 2240.2317364412306 2139.9456407929824 1961.6539611844712 2513.632867953209 2409.1201935320064 2293.94862945493 2624.2986268074997 1665.313213571103 2172.656680958278 1.0865723204451219 1.031102500489469 0.9849442203860448 0.9028826221726199 1.156939745696287 1.1088361150871906 1.0558265599713412 1.2078754318652956 0.7664870516204132 1.0 11.085244505287854 -8.267262815735785 24.99933463844805 0.8832435446344699 1.0615156770340537 0.3670398458287638 0.09625130010934586 571.6273811783326 2453890.8859714083 0.0847081370476292 0.024272618742563676 5.4042718143704174e-09 8.267262815735785 0.17827213239958384 SRS(ph)PLHPMSEIPR ddPTM_A459_Selumetinib_30min_R2 2 SRSPLHPMSEIPR 13 1 Q9NVW2-2;Q9NVW2 Q9NVW2-2 RLIM E3 ubiquitin-protein ligase RLIM 1 S(0.233)RS(0.767)PLHPMSEIPR;S(0.231)RS(0.768)PLHPMSEIPR 81.52600000000002 0.019182 50296000.0 62191.0 53900.0 69318.0 67608.0 72117.0 53100.0 53496.0 59295.0 51390.0 65232.0 True False 58734.67319029836 58033.95668418382 64858.155347731954 58399.67376969487 63057.01772583995 60414.04300619275 55983.67000031302 59467.538633184326 61669.43595657153 63348.582666909635 0.9271663345512958 0.9161050530416692 1.0238296204472281 0.9218781433005944 0.9953974512326069 0.9536763170196426 0.8837398982496304 0.9387351086585148 0.9734935394029705 1.0 15.95102472105768 SRS(ph)PLLVTVVESDPRPQGQPR ddPTM_A459_Selumetinib_30min_R2 3 SRSPLLVTVVESDPRPQGQPR 21 2 A0A2R8YH03;Q5VWN6;Q5VWN6-2 A0A2R8YH03 FAM208B Protein FAM208B 1 S(0.356)RS(0.644)PLLVTVVESDPRPQGQPR;S(0.17)RS(0.41)PLLVT(0.41)VVES(0.009)DPRPQGQPR;S(0.245)RS(0.755)PLLVTVVESDPRPQGQPR 125.04 2.7451e-05 50154000.0 43054.8 34075.6 49905.0 42728.9 52458.0 35485.1 39013.9 46418.5 37280.9 45786.3 True False 40661.986578020245 36689.088949676676 46694.16663245567 36909.15010853615 45867.75705952979 40372.850423334305 40828.12365457622 46553.57015000362 44738.12171537942 44464.330551905936 0.9144855229643685 0.8251353049574705 1.0501488733299764 0.8300844665917064 1.0315629739659646 0.9079828690146274 0.9182219353761563 1.04698686727463 1.006157546061643 1.0 15.440360844367502 -6.192728731524333 0.32049795594522446 1.020146185972527 0.856002166592359 0.21052327678272553 0.07199535278943377 4.627545032545916 0.7593222056437958 0.0841441053553503 0.2784887340932247 6.416102132178169e-07 6.192728731524333 -0.16414401938016798 SRS(ph)PSTESQLMSK ddPTM_A459_Selumetinib_30min_R1 2 SRSPSTESQLMSK 13 1 P35612;A0A1C7CYY0;P35612-5;P35612-6;P35612-4;P35612-3 P35612 ADD2 Beta-adducin 1 SRS(0.954)PS(0.045)TESQLMSK;S(0.003)RS(0.901)PS(0.094)T(0.003)ESQLMSK 189.8 0.00075437 36506000.0 5158.6 6671.8 7151.599999999999 6103.1 6000.200000000001 5670.4 6055.1 5188.3 3856.0 4794.4 True False 5278.785343111736 5890.662554364327 6180.452000926858 5037.308154375792 5457.482969421353 5613.360924311265 5598.35893201102 5050.689430026468 6543.350368902832 5409.807941410736 0.975780545313623 1.088885708727803 1.1424531273313852 0.9311436207959342 1.0088127025075468 1.0376266560855851 1.0348535461225847 0.9336171421844193 1.209534689543248 1.0 12.401361661173937 -10.665293087415503 11.177086496239111 0.9999869001712518 1.037221050575187 0.01928094038858197 0.08367134974934734 0.0 0.0 0.07787054877050263 0.01888638221797611 2.1612594866629258e-11 10.665293087415503 0.037234150403935296 SRS(ph)PVDLR ddPTM_A459_Selumetinib_30min_R2 2 SRSPVDLR 8 1 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 S(0.231)RS(0.769)PVDLR;S(0.385)RS(0.615)PVDLR 70.41199999999998 0.039279 48157000.0 51406.0 45503.0 57724.0 57958.0 63005.0 45501.0 43774.0 53339.0 45078.0 53725.0 True False 48549.060314522656 48992.93378479431 54010.10068513917 50064.020416873325 55089.748628153466 51768.34973304662 45809.57773653546 53494.207659253225 54094.859584555976 52173.819655686166 0.9305253216060353 0.9390329116809222 1.0351954493953344 0.9595621088749843 1.0558887386760365 0.9922284792389097 0.8780184782108991 1.0253074820337245 1.0368199978753223 1.0 15.67103843677164 -5.13664137040682 7.373981346295404 0.9949349175652221 0.93284924245586 0.21581674877362822 0.04793713916945997 0.4105755628055313 22.580109008284683 0.012551423829674823 0.03378248320518838 7.300601269219761e-06 5.13664137040682 -0.06208567510936214 SRS(ph)QPCDLDAR ddPTM_A459_Selumetinib_30min_R1 2 SRSQPCDLDAR 11 1 Q9NYF3 Q9NYF3 FAM53C Protein FAM53C 1 S(0.186)RS(0.814)QPCDLDAR;S(0.372)RS(0.628)QPCDLDAR 168.89 0.0021516 31693000.0 4441.799999999999 5559.200000000001 6060.5 6284.9 5975.4 4749.0 5696.6 4814.5 2641.3 4237.5 True False 4545.285297761735 4908.326279598035 5237.517387943571 5187.360197184447 5434.9261250425525 4701.229371746998 5266.90087564103 4686.803820299985 4482.09318708067 4781.424401745371 0.9506132306729689 1.0265406011242886 1.0953885177044127 1.084898507501425 1.1366751136039361 0.983227795054315 1.1015338596001738 0.9802107963035352 0.9373970621483766 1.0 12.223224750401938 -7.882571670760845 6.717540893876098 0.965757302039822 1.056101188797678 0.31617802283967156 0.05500274589009362 0.2507139934308359 13.58598243292482 0.03102033679258859 0.014752671976728951 1.3104737596231585e-08 7.882571670760845 0.09034388675785587 SRS(ph)QPCDLDAR ddPTM_A459_Selumetinib_30min_R2 4 SRSQPCDLDAR 11 1 Q9NYF3 Q9NYF3 FAM53C Protein FAM53C 1 S(0.181)RS(0.819)QPCDLDAR;S(0.428)RS(0.572)QPCDLDAR;S(0.4)RS(0.6)QPCDLDAR;S(0.02)RS(0.98)QPCDLDAR 141.59 0.004707899999999999 24021700.0 76626.7 81942.9 83785.3 88545.0 96992.6 66144.1 67896.2 69241.4 67962.6 74626.7 True False 72368.09477498414 88227.65694204831 78394.64501653732 76485.01825135527 84807.52246315437 75254.8493786425 71053.50783376796 69442.8810104691 81557.0190337048 72472.0332675477 0.9985658123847604 1.217402809940974 1.0817227209167004 1.055372876996464 1.1702103368628736 1.0383984826370385 0.9804265815401796 0.9582024662410703 1.1253585052956596 1.0 16.145136750536352 -6.955655585214641 9.38174190611203 1.0120588568726852 1.106790561628285 0.27253918348330075 0.06937314059029798 0.4276637299723675 85.84292882422035 0.02356475307640717 0.020753170744328652 1.1075017337983196e-07 6.955655585214641 0.09473170475559978 SRS(ph)SDIVSSVR ddPTM_A459_Selumetinib_30min_R1 2 SRSSDIVSSVR 11 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 S(0.002)RS(0.959)S(0.039)DIVSSVR;S(0.024)RS(0.951)S(0.024)DIVSSVR 135.81 0.0069627 55192000.0 6043.4 6759.9 7328.1 8664.6 7770.0 6647.3 7188.6 7025.4 3392.1 5864.2 True False 6184.199461590632 5968.44776540775 6332.984270371961 7151.4902646858945 7067.204871904919 6580.434197265494 6646.358114424936 6839.063570284661 5756.145950818285 6616.927192145179 0.9346029179422997 0.901996892529326 0.9570884016813301 1.0807872078712435 1.068049362896762 0.9944849030645213 1.0044478232002754 1.0335709267593538 0.8699122392719222 1.0 12.691945689937057 -5.530032230258374 24.82044465206127 1.011237932926957 0.9211105784821807 0.3062535641348325 0.05434776119785667 172.54354260868016 598672.3403083577 0.014993500071920076 0.026041914090216552 2.9509902169611222e-06 5.530032230258374 -0.09012735444477626 SRS(ph)SDIVSSVR ddPTM_A459_Selumetinib_30min_R2 3 SRSSDIVSSVR 11 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 S(0.06)RS(0.64)S(0.3)DIVSSVR;S(0.001)RS(0.705)S(0.293)DIVSSVR;S(0.002)RS(0.688)S(0.308)DIVS(0.001)S(0.001)VR 107.11 0.0059046 95140600.0 82200.0 61889.0 99816.0 101388.0 124001.0 70900.0 60853.2 75922.0 74261.0 75892.2 True False 77631.65307267163 66635.68729550007 93393.94723144357 87578.77949594455 108422.8857969949 80665.83143388067 63682.99437832818 76142.92045043633 89115.27502570435 73700.99499438363 1.0533324967809123 0.9041355181239824 1.2672006292257065 1.1882984687332712 1.4711183452171475 1.0945012538843986 0.864072383055088 1.0331328695933994 1.2091461591867976 1.0 16.16939647599019 -6.997318327978421 24.99996249111655 1.0221971730041728 1.1788755124118189 0.1701967172655755 0.15655822607192513 159.59343468537995 1487795.0913364552 0.05970194545763533 0.05235397104655321 1.0061938812621754e-07 6.997318327978421 0.15667833940764608 SRS(ph)TCGDSEVEEESPGK ddPTM_A459_Selumetinib_30min_R1 1 SRSTCGDSEVEEESPGK 17 1 O95696;O95696-2 O95696 BRD1 Bromodomain-containing protein 1 1 S(0.094)RS(0.747)T(0.094)CGDS(0.066)EVEEESPGK 102.78 0.025341 0.0 1243.4 1154.7 1348.8 1887.8 1274.0 1618.0 1395.2 1581.3 1018.8 1438.2 True False 1272.3688007647675 1019.5071871945333 1165.640368428064 1558.1311683948513 1158.7669249429684 1601.7243890264574 1289.9589407180351 1539.3587872137018 1728.829189792067 1622.8069792543224 0.7840543065383039 0.628236876121272 0.7182865142493251 0.9601457156111138 0.7140509868126278 0.9870085657152199 0.7948936362787702 0.9485778696373582 1.0653326069539468 1.0 10.664275696973796 -6.532254798802638 0.390301157972057 1.0294295679107988 0.6499046989628566 0.5198817042061138 0.09820514559949947 1.3738588143182802 0.40170514176641753 0.10039266556284558 0.21090943278479798 2.935926650371053e-07 6.532254798802638 -0.37952486894794213 SRS(ph)TCGDSEVEEESPGKR ddPTM_A459_Selumetinib_30min_R1 2 SRSTCGDSEVEEESPGKR 18 2 O95696;O95696-2 O95696 BRD1 Bromodomain-containing protein 1 1 S(0.239)RS(0.717)T(0.045)CGDSEVEEESPGKR;S(0.227)RS(0.731)T(0.042)CGDSEVEEESPGKR 130.52 0.00065279 7487800.0 1324.2 1755.6 1707.52 2224.8 1796.5299999999997 1691.1 1499.7 1707.1399999999999 956.72 1386.9299999999998 True False 1355.0512835553366 1550.0535358437014 1475.6481627359788 1836.280444668327 1634.0341787031334 1674.0890693959468 1386.5764215846032 1661.8611016277732 1623.4839639358706 1564.9559753422309 0.8658718231731781 0.9904774065639319 0.9429326996967299 1.1733751451166297 1.0441406687787471 1.069735568139449 0.8860162480170607 1.0619219504014168 1.037399127845012 1.0 10.611906357124257 -4.666428795727554 1.4440358408656826 1.0326837408833314 0.7701423536426713 0.3167018157696936 0.07202352052956514 1.9620119286551267 3.0773381581887462 0.021042823821342815 0.8067610970485676 2.1556150360793967e-05 4.666428795727554 -0.2625413872406601 SRS(ph)TTELDDYSTNK ddPTM_A459_Selumetinib_30min_R1 1 SRSTTELDDYSTNK 14 1 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 S(0.058)RS(0.865)T(0.077)TELDDYSTNK 249.86 9.0606e-27 37804000.0 9385.9 10823.0 9469.5 10937.0 10789.0 9927.0 12295.0 10059.0 5641.8 8223.2 True False 9604.573208217815 9555.838128523805 8183.593912240186 9027.058262916882 9813.13685495266 9827.143392994834 11367.578251238716 9792.202643763118 9573.72253923133 9278.727820751043 1.0351174637042428 1.0298651187022676 0.8819737005258751 0.9728767172940105 1.0575950760196304 1.0591046081788615 1.2251225028733084 1.055338925004755 1.0317925823646383 1.0 13.179711299873908 -6.3988926358791804 3.135739669255498 1.0855662986882761 0.9765696848806112 0.2960214454808524 0.06826134682767518 0.3142126479611199 5.851902130700932 0.02352684557830067 0.02689445608996718 3.991235595072664e-07 6.3988926358791804 -0.1089966138076649 SRSES(ph)DLSQPESDEEGYALSGR ddPTM_A459_Selumetinib_30min_R2 1 SRSESDLSQPESDEEGYALSGR 22 1 Q15751;H0YNB1 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 S(0.315)RS(0.315)ES(0.37)DLSQPESDEEGYALSGR 92.363 0.003694 0.0 3792.7 5307.3 8054.8 9415.2 11073.0 7811.7 4807.7 4183.1 7190.2 6002.0 True False 3581.916917381046 5714.35284434079 7536.5629374031405 8132.8335178740745 9681.910746124018 8887.690767447762 5031.267576276817 4195.272128450516 8628.440910973743 5828.706664931197 0.6145303106316686 0.9803809271654681 1.2930077580927815 1.3953067096009155 1.6610735970598556 1.5248135269735132 0.8631876444473993 0.7197603807533584 1.4803354169265943 1.0 12.508960083167421 -7.280767624612045 24.818876169310908 0.9924675661949408 1.2607776385839473 0.10210616166183673 0.32779581276155806 1780.0459883298795 2285699.202615499 0.14842050804299026 0.10023768218474993 5.238806713494506e-08 7.280767624612045 0.2683100723890065 SRSES(ph)DVSSVEQDSFIEPYATTSQLRPR ddPTM_A459_Selumetinib_30min_R2 1 SRSESDVSSVEQDSFIEPYATTSQLRPR 28 2 K7EQI2;A0A0C4DGP8;K7EJF0;Q96ST8-3;Q96ST8 K7EQI2 CEP89 Centrosomal protein of 89 kDa 1 S(0.069)RS(0.173)ES(0.619)DVS(0.069)S(0.069)VEQDS(0.002)FIEPYATTSQLRPR 59.789 0.005203899999999999 6930000.0 6138.3 4196.6 5759.0 5891.9 6092.0 6091.9 6484.4 6181.4 4151.9 6081.6 True False 5797.15785956181 4518.46572580419 5388.4722099251 5089.413055905585 5326.668496828998 6931.003928237769 6785.937448594839 6199.3868506141425 4982.39601377874 5906.00840610556 0.9815695239391766 0.7650625287178824 0.9123712394913902 0.8617348140995212 0.9019066907054099 1.1735513144669047 1.1489887893792394 1.0496745727969656 0.8436147853477484 1.0 12.527967694543737 -6.617932276916373 8.048133719532268 1.0525297219368706 0.8752336366087107 0.3966389039910304 0.0976762950243795 0.24478828115647414 18.26906801505762 0.0331327889899973 0.033107487547027456 2.410281254213702e-07 6.617932276916373 -0.17729608532815988 SRSES(ph)ETSTMAAK ddPTM_A459_Selumetinib_30min_R1 1 SRSESETSTMAAK 13 1 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 SRSES(0.986)ET(0.011)S(0.003)T(0.001)MAAK 154.72 0.0017903 11632000.0 2064.8 2676.3 3275.9 3609.4 2624.8 2904.9 2514.9 2372.6 1378.3 2188.2 True False 2112.905822598594 2362.9575518218844 2831.0507732306482 2979.0860468293135 2387.387303446078 2875.6793434381702 2325.1990682423943 2309.670940709055 2338.874432950927 2469.0767848729706 0.8557473123328966 0.9570206833172481 1.1466029694075717 1.206558688284205 0.9669149692195192 1.1646779723726246 0.941728131943058 0.935439089970579 0.947266787035648 1.0 11.269755987660774 SRSES(ph)ETSTMAAK ddPTM_A459_Selumetinib_30min_R2 2 SRSESETSTMAAK 13 1 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 S(0.025)RS(0.284)ES(0.343)ET(0.343)S(0.003)T(0.001)MAAK;S(0.026)RS(0.283)ES(0.676)ET(0.011)S(0.004)TMAAK 148.18 0.0026267 55242000.0 69793.0 63605.0 69164.0 71337.0 75077.0 54746.0 58741.0 54307.0 47597.0 65705.0 True False 65914.18446351556 68483.29897769034 64714.06354006943 61620.777536810965 65645.1560631042 62286.76456529241 61472.57289308329 54465.024378992195 57117.729971296685 63807.925927908145 1.033009355890789 1.0732726065264142 1.0142010196850006 0.9657229355242125 1.0287931335876956 0.9761603070387466 0.9634002672730125 0.8535777270135405 0.8951510198878707 1.0 15.961448019631684 -7.2185343524775565 1.7351952749202015 0.907977207865361 1.0226618973539594 0.5088774106192799 0.04384084821052598 0.281120285503159 1.656410001613866 0.023461848033138572 0.014973517865260126 6.04596526168739e-08 7.2185343524775565 0.11468468948859845 SRSESET(ph)STMAAK ddPTM_A459_Selumetinib_30min_R1 1 SRSESETSTMAAK 13 1 A0A087WVF1;Q96B23-2;Q96B23 A0A087WVF1 C18orf25 Uncharacterized protein C18orf25 1 SRSES(0.085)ET(0.907)S(0.002)T(0.006)MAAK 212.03 5.2408e-05 10617000.0 1666.2 1721.4 2213.3 2382.7 1990.0 2015.0 1760.0 1598.0 1014.7 1291.2 True False 1705.01921813918 1519.857687742851 1912.746016786651 1966.606173818421 1810.0048513630359 1994.7309294736162 1627.241783015871 1555.6158489644567 1721.8717892442187 1456.9380973530665 1.170275676939756 1.0431861796352881 1.3128533190680416 1.3498213667356962 1.2423347667628524 1.3691253822640783 1.1168915041567027 1.0677295430675235 1.1818427923413342 1.0 10.508723865881286 -7.448150128650856 9.892516906638663 1.0933171538297717 1.245888244939114 0.3850300076724943 0.09720742964780257 0.6270859510351386 80.38267201937458 0.043665997278957286 0.029383298220476348 3.5632793526999854e-08 7.448150128650856 0.1525710911093423 SRSEYLNR ddPTM_A459_Selumetinib_30min_R2 2 SRSEYLNR 8 1 P46087-2;P46087;P46087-4;P46087-3;F5GYR3 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 0 ; 113.26 0.030503 2558200.0 7287.799999999999 4973.8 8445.7 8098.6 7346.5 3663.54 5776.200000000001 6086.4 5317.9 7364.700000000001 False True 6882.773251374899 5355.274466712308 7902.312856982881 6995.55670913576 6423.5669914567015 4168.159380695054 6044.80474532316 6104.110416342234 6381.628594540796 7152.06197521139 0.9623480997829955 0.7487734985062158 1.104899941355628 0.9781174622622024 0.8981419643342566 0.5827912838481601 0.8451834962104753 0.8534756043080595 0.892278145331952 1.0 12.804143522713343 -6.532657584943836 24.998415666879488 0.816709900593793 0.9445219026388672 0.14415100399392278 0.12714998623082482 368.5444633754642 942132.4005167023 0.042229832216918124 0.04227642599637258 2.9332049893617564e-07 6.532657584943836 0.12781200204507415 SRSPGS(ph)PVGEGTGSPPK ddPTM_A459_Selumetinib_30min_R2 1 SRSPGSPVGEGTGSPPK 17 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5;A0A0A0MSR2 P35611 ADD1 Alpha-adducin 1 S(0.353)RS(0.061)PGS(0.585)PVGEGTGSPPK 127.1 0.0053082 9733200.0 9015.1 9879.6 9251.1 9315.8 11648.0 7298.4 7084.3 6444.1 5686.3 9888.6 True False 8514.076832304652 10637.333552079075 8655.894297836103 8046.971969348646 10184.674105558794 8303.688351721223 7413.733987274142 6462.851264121816 6823.71888849684 9603.090424331665 0.8865975905769101 1.1076989887679194 0.9013654891663188 0.8379564925224248 1.0605621373462808 0.8646891765886006 0.7720154304170376 0.6729970226820605 0.710575303051126 1.0 13.229283046992414 -7.068394231622155 3.6566641934603155 0.7630827022112853 0.957991002282029 0.33014713341329416 0.11118403147078695 0.24555120105735168 6.386126133693505 0.04312664315551336 0.03367007323894176 8.542908766754046e-08 7.068394231622155 0.19490830007074378 SRSPS(ph)TESQLMSK ddPTM_A459_Selumetinib_30min_R2 2 SRSPSTESQLMSK 13 1 P35612;A0A1C7CYY0;P35612-5;P35612-6;P35612-4;P35612-3 P35612 ADD2 Beta-adducin 1 S(0.002)RS(0.016)PS(0.732)T(0.249)ES(0.001)QLMSK;S(0.001)RS(0.003)PS(0.926)T(0.069)ESQLMSK 108.34 0.0034699 9442500.0 122336.0 114104.0 112408.0 116845.0 117091.0 72788.0 98738.0 91952.0 70580.0 103680.0 True False 115537.05486980965 122855.40989781292 105175.79166057661 100930.50943113236 102380.98177317863 82813.88629632311 103329.51264563538 92219.56509652705 84697.9721699713 100686.48900700854 1.1474931344737564 1.2201777131116496 1.044586942079742 1.0024235667221135 1.0168293957102044 0.8224925420783978 1.0262500327967823 0.9159080429362064 0.8412049422447899 1.0 16.619510577341117 -5.634460606548556 1.1084990562097017 0.9266381049180408 1.2038623855150339 0.6620719045939205 0.06800530965970565 0.3539948035559398 0.7943000091554938 0.023897573328395545 0.08196655811470917 2.3202746406522157e-06 5.634460606548556 0.2772242805969931 SRT(ph)ASGSSVTSLDGTR ddPTM_A459_Selumetinib_30min_R1 2 SRTASGSSVTSLDGTR 16 1 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 S(0.082)RT(0.918)ASGSSVTSLDGTR;S(0.017)RT(0.981)AS(0.002)GSSVTSLDGTR 179.66 2.4359000000000003e-08 4582700.0 2029.99 1449.13 1990.35 2514.27 1690.91 2015.3600000000001 1920.46 1657.13 1347.43 1578.46 True False 2077.284817327064 1279.4651859177397 1720.0714022099626 2075.1999431932 1537.9674890544081 1995.0873082004698 1775.598156028784 1613.177529283148 2286.4902976065205 1781.0707165024173 1.1663123749551831 0.7183685487964752 0.9657513237811004 1.1651418014824138 0.863507257069835 1.1201617598420395 0.996927376087357 0.9057346877562672 1.2837728880842094 1.0 10.79852908370799 -6.522976259641858 0.5772681232081924 1.0646538498899272 0.9455367123607153 0.042755834008459837 0.15607207924455738 3.129110934558671 2.257479205148955 0.12086818719059653 0.18093057515365998 2.999326470272797e-07 6.522976259641858 -0.11911713752921183 SRT(ph)GS(ph)ESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 1 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.497)RT(0.666)GS(0.573)ES(0.253)S(0.011)QTGTSTTSSR 99.603 0.010071 24090000.0 4460.8 4534.4 6062.0 3753.5 5352.3 3663.3 2662.5 3592.0 3328.5 3781.4 True False 4212.886593997249 4882.173899605991 5671.977519806554 3242.2668248513405 4679.8962238309 4167.886322873556 2786.3115256436613 3602.4521253123867 3994.2930060604845 3672.22115674289 1.1472311754049986 1.329487983217296 1.5445631615600641 0.8829170919888438 1.27440478775025 1.1349769376554382 0.7587537369658329 0.9810008633868921 1.0877049163355017 1.0 11.842437231248342 -6.438161335286117 1.0085902214899303 0.9664338048657976 1.3036495803954464 0.3318417786770006 0.17722316582940256 0.6083305856235812 1.3253623241289396 0.0886891478718818 0.11334504399150924 3.646184702949248e-07 6.438161335286117 0.3372157755296489 SRT(ph)GSESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 3 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.019)RT(0.958)GS(0.023)ESSQTGTSTTSSR;S(0.329)RT(0.671)GSESSQTGTSTTSSR;S(0.43)RT(0.57)GSESSQTGTSTTSSR 178.22 2.5592e-09 68880000.0 4372.84 4872.700000000001 4673.79 5415.83 5140.8 4772.44 5544.8 4402.0 3401.7400000000002 5985.46 True False 4129.815058665472 5246.420421800045 4373.083439837791 4678.184611172141 4494.966744664889 5429.800290103101 5802.644186812763 4414.809091209672 4082.1830525570667 5812.644217707275 0.7104881881613642 0.9025875703552746 0.7523397744723311 0.8048289962287408 0.7733084249284868 0.9341360122407111 0.9982796072630683 0.7595182030513195 0.7022936377425889 1.0 12.50497889096839 -6.7401331577942365 24.98277367874275 0.8712800350350637 0.7939119435313778 0.1676625884756031 0.09936677829197876 544.8507871307422 638867.6623663557 0.03396285533918389 0.03393154892662698 1.8191430108366163e-07 6.7401331577942365 -0.07736809150368584 SRT(ph)PPSAPSQSR ddPTM_A459_Selumetinib_30min_R1 2 SRTPPSAPSQSR 12 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.007)RT(0.992)PPSAPSQSR;S(0.023)RT(0.976)PPSAPSQSR 146.84 0.0066899 425019000.0 5479.5 6166.4 6356.4 6657.5 6295.1 5242.2 5511.5 5265.0 3075.8 4131.299999999999 True False 5607.161688749025 5444.435021318411 5493.23579320592 5494.892601752693 5725.709316490175 5189.468227536772 5095.763117665893 5125.355096869751 5219.407952456259 4661.592597269767 1.2028424989418993 1.1679345433376447 1.1784032342129676 1.178758651060794 1.2282732128594094 1.1132393316773703 1.0931378088789687 1.0994858495080853 1.1196619703560533 1.0 12.186607209424547 -8.200525320994952 0.35040221665984483 0.9910110003027541 1.2052203153193777 0.7841566078721345 0.029395189058262123 0.6510844308642115 0.25243926997989286 0.05194516941655068 0.03723712480265026 6.301946022139984e-09 8.200525320994952 0.21420931501662355 SRT(ph)PPSAPSQSR ddPTM_A459_Selumetinib_30min_R2 5 SRTPPSAPSQSR 12 1 Q9UQ35;I3L3Q8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.024)RT(0.976)PPSAPSQSR;S(0.038)RT(0.962)PPSAPSQSR;S(0.005)RT(0.995)PPSAPSQSR;S(0.01)RT(0.99)PPSAPSQSR;S(0.027)RT(0.971)PPSAPS(0.001)QS(0.001)R 161.49 0.0050017 972217900.0 106683.40000000001 97144.7 113667.59999999999 124391.7 120180.0 102988.26000000001 87837.0 103631.3 86783.79999999999 119635.2 True False 100754.36371548742 104595.38612055696 106354.35036792519 107449.33587234841 105081.91397716831 117173.9579806584 91921.59454571345 103932.84992591481 104142.98494197117 116181.02092642048 0.8672187842048398 0.9002794543077659 0.9154193130673323 0.9248441356045408 0.904467125002444 1.0085464652171268 0.7911928627648146 0.8945768344705574 0.8963855207291282 1.0 16.82601488696873 -4.789553371469938 2.7873246182023896 0.9117016607524489 0.8594042465211026 0.06032885911005903 0.056981892987026175 1.488362554843539 16.073429319081864 0.01439165718801154 0.17976860466868821 1.6234788250928906e-05 4.789553371469938 -0.05229741423134626 SRT(ph)PVQDHR ddPTM_A459_Selumetinib_30min_R2 2 SRTPVQDHR 9 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.235)RT(0.765)PVQDHR;S(0.196)RT(0.804)PVQDHR 92.247 0.036195 292264000.0 23837.7 28936.1 17544.9 21403.6 22532.5 18841.7 39311.9 68705.0 33736.5 60583.0 True False 22512.896063873803 31155.405825773843 16416.080235442765 18488.392756730565 19701.765906894183 21436.97314707688 41139.98124505205 68904.920175275 40484.7426765689 58833.811376462254 0.3826523479809873 0.5295493373090944 0.2790245923453869 0.31424774843207337 0.3348714870914568 0.3643648549285251 0.6992574555778481 1.1711789286328966 0.6881203466067762 1.0 15.84435787960842 -7.439190911557715 3.4380238817650746 0.9488390788258265 0.3675610986734516 0.8090628435716553 0.12821424399196552 0.098250642194988 2.211474941789402 0.057778203641098445 0.03572510673860161 3.637550978338042e-08 7.439190911557715 -0.5812779801523749 down SRTDSLAAT(ph)PPAAK ddPTM_A459_Selumetinib_30min_R1 2 SRTDSLAATPPAAK 14 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 S(0.001)RTDSLAAT(0.999)PPAAK;SRT(0.001)DS(0.044)LAAT(0.955)PPAAK 127.05 0.012933000000000002 36323000.0 6147.9 7496.4 8183.1 9024.1 8193.7 7119.9 6832.6 6709.7 3358.3 5626.0 True False 6291.134108269032 6618.718003018185 7071.879966550781 7448.2103383366775 7452.581281715233 7048.2802703519665 6317.211481042178 6531.736959822784 5698.789819472615 6348.151901880695 0.991018205850624 1.0426212392708079 1.1140061038009623 1.1732879826221676 1.1739765205535395 1.1102885342525992 0.9951260742785076 1.0289194494365677 0.897708483910774 1.0 12.632120934805569 -7.315951035328913 4.022477910066321 0.9794826576030506 1.1057481376552942 0.49098045861677087 0.06007896895898681 0.2209776568122975 7.440236368100684 0.028892010960200203 0.01932382328046062 4.8311326773014027e-08 7.315951035328913 0.12626548005224358 SRTDSLAAT(ph)PPAAK ddPTM_A459_Selumetinib_30min_R2 1 SRTDSLAATPPAAK 14 1 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 SRTDS(0.001)LAAT(0.999)PPAAK 80.596 0.04658 4221000.0 29773.0 30361.0 31678.0 34371.0 35641.0 25713.0 26526.0 26143.0 22937.0 33980.0 True False 28118.335850762203 32689.591073998236 29639.871968398573 29689.61050671787 31163.458945417337 29254.732350625898 27759.511560271832 26219.071801793372 27525.040913327117 32998.909109357235 0.8520989514404558 0.9906264163359483 0.8982076307484308 0.8997149090088867 0.9443784593649056 0.8865363474191446 0.8412251286331247 0.7945435927867882 0.8341197226281054 1.0 15.010130711640716 -7.023742055749066 4.3958928358025435 0.8512053388526223 0.9190970910949912 0.10666855426058353 0.060692821012748116 0.3212204103674895 14.844865777603633 0.02211927594386816 0.017842584310191326 9.467993350602027e-08 7.023742055749066 0.06789175224236887 SRTGS(ph)ESS(ph)QTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 1 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.328)RT(0.022)GS(0.655)ES(0.397)S(0.564)QT(0.035)GTSTTSSR 181.64 3.6648e-08 20734000.0 17291.0 19968.0 17826.0 22788.0 19221.0 12438.0 12360.0 11189.0 11839.0 17457.0 True False 16330.03544135726 21499.481392760335 16679.09456748131 19684.23508850736 16806.28614207981 14151.221599077693 12934.764490875361 11221.55813756133 14207.130809298513 16952.971051266886 0.9632550773533542 1.2681836905014765 0.9838449270657422 1.161108281786181 0.9913475396882652 0.8347340154291233 0.7629792118301737 0.6619228041873373 0.8380319158414903 1.0 14.049250511041611 -6.6742955484083515 2.58248306069548 0.7886335205486067 1.0985906532212455 0.5622838085710653 0.11363509996014952 0.18007108240183964 2.446369563841193 0.0394003832055583 0.03844813670524362 2.1169200271866573e-07 6.6742955484083515 0.3099571326726388 SRTGSES(ph)S(ph)QTGTSTTSSR ddPTM_A459_Selumetinib_30min_R1 1 SRTGSESSQTGTSTTSSR 18 1 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 S(0.015)RT(0.055)GS(0.019)ES(0.913)S(0.936)QT(0.041)GT(0.001)S(0.012)T(0.003)T(0.004)S(0.001)SR 145.48 0.0092252 6761300.0 1309.4 1155.5 1755.1 1748.6 1463.5 1023.7 1099.7 1012.2 717.55 790.03 True False 1339.9064723511226 1020.2135228226243 1516.7670600742108 1443.239835287233 1331.1266834019116 1013.4025074452315 1016.7487436264503 985.353167911028 1217.6299422215327 891.4380460438686 1.5030842337249586 1.1444581340792568 1.701483425354687 1.6190018383130687 1.4932352161873126 1.1368176531646048 1.1405714038554902 1.1053523823488882 1.3659165071821626 1.0 9.79999072540275 -6.759644943044554 24.936190349053398 1.1557435670012526 1.4915962666715694 0.5372415470034577 0.15889642402219556 39.29932986966092 546120.8728962897 0.055423906309367464 0.05273316029466844 1.7392221467425498e-07 6.759644943044554 0.33585269967031683 SRTPS(ph)ASNDDQQE ddPTM_A459_Selumetinib_30min_R2 1 SRTPSASNDDQQE 13 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 SRT(0.002)PS(0.989)AS(0.009)NDDQQE 127.07 0.009323200000000002 194750000.0 30343.0 36792.0 36415.0 36098.0 43285.0 29808.0 27095.0 32361.0 35223.0 55619.0 True False 28656.657532653 39613.828095074015 34072.09854565419 31181.390127476694 37847.1513271903 33913.781429917035 28354.97118772395 32455.165152348058 42268.58421284917 54013.134954483176 0.5305497923199967 0.7334110143478352 0.6308113493943042 0.5772927298841888 0.7007027338643473 0.6278802639116606 0.5249643667529882 0.6008754200195563 0.7825612093885843 1.0 15.721022665147837 -8.55549270308237 2.8691250485585624 0.9990848187686743 0.6196234167408153 0.7859687610419488 0.06270196068074681 0.12077036617581555 2.509627849735403 0.06088413835046901 0.016292879615697503 2.782962132159918e-09 8.55549270308237 -0.37946140202785894 SRTPSAS(ph)NDDQQE ddPTM_A459_Selumetinib_30min_R2 1 SRTPSASNDDQQE 13 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 SRT(0.001)PS(0.106)AS(0.893)NDDQQE 134.06 0.0059817 83002000.0 42878.0 48218.0 49969.0 51264.0 49758.0 33692.0 38597.0 45095.0 40514.0 64488.0 True False 40495.01241423378 51916.165554693405 46754.04894213361 44281.75476466744 43506.95519783606 38332.76717447545 40391.83697850455 45226.21898412089 48617.93205574115 62626.06388005379 0.6466159599586669 0.8289865646694194 0.7465589571728558 0.7070818764768488 0.6947100376795817 0.6120896763988438 0.6449684759985247 0.722162885260386 0.7763210561797068 1.0 15.934475586303455 -8.738053861513988 1.9640608730577682 0.9996899114939084 0.7011403629432124 0.7127479029393328 0.057326167985256665 0.4868034685827527 3.2655742543100286 0.060190605131018114 0.01672182766236134 1.8278735078977268e-09 8.738053861513988 -0.29854954855069604 SRTS(ph)VQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R1 3 SRTSVQTEDDQLIAGQSAR 19 1 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 S(0.004)RT(0.05)S(0.945)VQTEDDQLIAGQSAR;SRT(0.031)S(0.968)VQTEDDQLIAGQSAR;SRT(0.037)S(0.963)VQTEDDQLIAGQSAR 247.28 7.6593e-37 36545000.0 6874.1 6940.200000000001 7759.6 7911.8 7701.799999999999 6111.9 6743.099999999999 5443.0 2940.96 4721.3099999999995 True False 7034.253155329812 6127.638157588552 6705.8889404318015 6530.152652879752 7005.173549863227 6050.419835161191 6234.46253809904 5298.633958644267 4990.594320780208 5327.336127953847 1.3204072328793655 1.1502255555896543 1.2587696325832245 1.225781984848756 1.3149486688300656 1.135730821153399 1.1702776750626411 0.9946122848980803 0.9367898328384667 1.0 12.379198595190111 -7.620772989769281 1.5285327342994006 0.9565714814491788 1.240814232817515 0.8028201607395447 0.05730362031437122 0.1656455723726685 0.7405328366544007 0.039793696096143354 0.017437941209753744 2.3945670943928092e-08 7.620772989769281 0.2842427513683361 SRTS(ph)VQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R2 1 SRTSVQTEDDQLIAGQSAR 19 1 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 S(0.074)RT(0.227)S(0.7)VQTEDDQLIAGQSAR 160.98 8.574600000000002e-07 36956000.0 16830.0 15386.0 18333.0 27085.0 26924.0 14420.0 26581.0 21649.0 21141.0 16986.0 True False 15894.655975828031 16566.056726212464 17153.47473946117 23395.97627576891 23541.566416386057 16406.22410827305 27817.06916925228 21711.9950058151 25369.79072889431 16495.57004507186 0.9635711850150122 1.0042730673112847 1.0398837198467028 1.4183187493274039 1.4271447638403514 0.9945836405438135 1.6863357309414584 1.3162318699196258 1.5379759935288606 1.0 14.009791014196036 -5.707756997948883 5.958493119785521 1.35684849280904 0.9965705098746179 0.36572948188208565 0.203120640161708 0.1971580927890535 14.84352207411894 0.053286428860437614 0.09213568463168427 1.9599410182395943e-06 5.707756997948883 -0.36027798293442215 SRTSPITR ddPTM_A459_Selumetinib_30min_R2 1 SRTSPITR 8 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 86.882 0.045629 0.0 4592.4 4161.6 3678.2 6579.0 7656.0 3888.4 3361.5 3455.2 4329.4 5446.0 False True 4337.172792833787 4480.781338346924 3441.5486165213583 5682.928850591972 6694.184834491595 4423.991804619207 3517.816410685886 3465.2540599608474 5195.400973543115 5288.759829592686 0.8200736907290823 0.8472272295813461 0.6507288527765136 1.0745295747395742 1.2657381031059503 0.8364894506771203 0.6651495859203745 0.6552110838104978 0.9823476847015831 1.0 12.36871374661293 -10.30762147442616 12.795104442306473 1.0000041129787265 0.8643399896687523 0.043637443360687866 0.18742874954609315 0.0 0.0 0.1983119244613042 0.04809770655138047 4.924685780601149e-11 10.30762147442616 -0.13566412330997424 SRVPVRPPQQYS(ph)DDEDDYEDDEEDDVQNTNSALR ddPTM_A459_Selumetinib_30min_R2 1 SRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALR 34 2 Q92560;F8W6N3 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 S(0.017)RVPVRPPQQY(0.313)S(0.358)DDEDDY(0.313)EDDEEDDVQNTNSALR 61.525 0.00015626 3052600.0 7179.0 7345.3 9609.3 8690.1 10263.0 5678.2 5543.8 5064.6 5875.3 7883.7 True False 6780.019919813993 7908.660891137948 8991.048099814772 7506.493388741346 8973.67018761589 6460.320508432459 5801.597684831302 5079.337147510336 7050.524169598066 7656.0770966874525 0.8855736213455188 1.0329912814696942 1.1743674973838651 0.9804620948748248 1.1720976779999406 0.8438160205084193 0.7577768107039405 0.6634386100563182 0.920905586576265 1.0 12.902389642496557 -6.87831798453833 6.726535467500704 0.8069280812047415 1.0506676569502946 0.4442328021967893 0.11665385465796865 0.18031986029713623 9.918567114785763 0.04042788830064197 0.03567262459362502 1.3233722251582892e-07 6.87831798453833 0.24373957574555316 SRVPVRPPQQYSDDEDDY(ph)EDDEEDDVQNTNSALR ddPTM_A459_Selumetinib_30min_R2 1 SRVPVRPPQQYSDDEDDYEDDEEDDVQNTNSALR 34 2 Q92560;F8W6N3 Q92560 BAP1 Ubiquitin carboxyl-terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase 1 S(0.055)RVPVRPPQQY(0.17)S(0.184)DDEDDY(0.591)EDDEEDDVQNTNSALR 54.255 0.0016028 7696300.0 3085.6 5568.7 7131.3 4939.3 7259.1 2290.6 4082.9 2031.1 1684.6 4948.2 True False 2914.114704635472 5995.801383807312 6672.47992197237 4266.5588192322475 6347.14696082262 2606.1093580034867 4272.762940112868 2037.0101647332933 2021.5670716567508 4805.332609032412 0.6064335066334253 1.2477390997945115 1.3885573517700625 0.8878800212939578 1.3208548662983526 0.5423369348262962 0.8891711121268709 0.42390617475768444 0.42069243403815243 1.0 12.230420577637036 -6.770895948074297 24.998200071607936 0.633837264199117 1.1043650652590637 0.3883566334607389 0.2720543546630239 197.0318644199082 520845.62790460605 0.09363406366523472 0.08364585203147512 1.694743792785648e-07 6.770895948074297 0.47052780105994674 SRWDETPASQMGGST(ph)PVLTPGK ddPTM_A459_Selumetinib_30min_R1 2 SRWDETPASQMGGSTPVLTPGK 22 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 SRWDETPASQMGGS(0.224)T(0.776)PVLTPGK;SRWDETPASQMGGS(0.107)T(0.881)PVLT(0.011)PGK 109.32 7.1997e-05 66348000.0 9624.900000000001 10201.400000000001 11586.5 12788.3 11830.6 10172.0 10441.4 10193.6 5599.2 8287.0 True False 9849.141443204768 9007.015345497812 10013.116940088801 10555.063471121885 10760.52431886208 10069.678915437044 9653.796791580635 9923.232614520708 9501.433450612227 9350.717172215658 1.0533033201421285 0.9632432656888492 1.0708394613668106 1.128797211671076 1.1507699485164053 1.0768884065232642 1.0324124464234181 1.0612269018259048 1.0161181517546485 1.0 13.190861304327631 -10.331733941295482 10.709699949091405 0.9999990190607805 1.06308749952215 0.11723890784448399 0.05046947355757014 0.0 0.0 0.054336648894744106 0.013178573102066536 4.658714095690541e-11 10.331733941295482 0.0630884804613695 SRWDETPASQMGGST(ph)PVLTPGK ddPTM_A459_Selumetinib_30min_R2 2 SRWDETPASQMGGSTPVLTPGK 22 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 SRWDETPASQMGGS(0.014)T(0.969)PVLT(0.017)PGK;SRWDETPASQMGGS(0.332)T(0.664)PVLT(0.004)PGK 101.71 0.00015773 41046000.0 166676.0 160683.0 170106.0 199484.0 191406.0 124829.0 127997.0 121619.0 110513.0 162593.0 True False 157412.81517689332 173006.86942272144 159161.56515740915 172313.93507090586 167359.86708864916 142023.06166516067 133949.11412124382 121972.89115489069 132618.68799121596 157898.51762265235 0.9969239581658407 1.0956839369206441 1.0079991095152345 1.0912954577743639 1.0599204451596413 0.8994578530785766 0.8483240763624958 0.7724764804086564 0.8398982459616853 1.0 17.26863810143935 -6.857960541944278 3.5792915865437895 0.8488924536724387 1.0535364671798182 0.6775594854068105 0.06131920019895025 0.12371867999550223 3.077456149431669 0.02174929375187338 0.01923624927902894 1.3868818290327734e-07 6.857960541944278 0.20464401350737949 SS(ph)AEAQTPEDTPNK ddPTM_A459_Selumetinib_30min_R1 2 SSAEAQTPEDTPNK 14 0 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7;O43493-4 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 S(0.031)S(0.969)AEAQTPEDTPNK;S(0.226)S(0.774)AEAQTPEDTPNK 253.06 9.7696e-28 7622700.0 6568.5 7099.7 3980.8 3207.9 4356.4 5470.3 5727.1 7478.0 3162.6000000000004 6609.200000000001 True False 6721.533269923899 6268.463823439012 3440.2292249691864 2647.7004847408853 3962.3643891848906 5415.273748635002 5295.100236085336 7279.659148032667 5366.701212835089 7457.555199059708 0.9013051986221153 0.8405521187733719 0.4613079130011603 0.3550359888820833 0.5313221670400091 0.7261459827099627 0.7100316517607504 0.976145526747228 0.7196327844159643 1.0 12.864487035749558 -7.429948529312804 1.9364795719618801 0.886070212175704 0.6134406767236894 0.30983697555229917 0.1717135368503971 0.4754464063439583 3.4866173941976526 0.10836433328452665 0.05958276410224433 3.715792644409276e-08 7.429948529312804 -0.2726295354520146 SS(ph)AEAQTPEDTPNK ddPTM_A459_Selumetinib_30min_R2 2 SSAEAQTPEDTPNK 14 0 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7;O43493-4 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 S(0.121)S(0.879)AEAQTPEDTPNK;S(0.023)S(0.977)AEAQTPEDTPNK 323.16 1.1815999999999992e-109 24345000.0 123816.0 40726.0 73642.0 85043.0 70122.0 77300.0 121995.0 104283.0 98092.0 55433.0 True False 116934.80239471918 43849.553245270305 68903.95389534716 73459.99669264218 61312.64746136617 87947.37334046524 127668.00922850659 104586.44626501987 117713.14091947896 53832.50525776924 2.1721969251624764 0.8145553144016426 1.2799692967178558 1.3646029725142739 1.1389521473648558 1.6337224678536109 2.3715784472074377 1.9428121683028248 2.1866554483360274 1.0 15.716189946628079 -7.0017679911593556 7.5694543230173625 1.9614531202351728 1.3258947208921654 0.20934715525517045 0.4647633837062952 0.1533184639427065 66.27998075894217 0.15957686828024747 0.1338839933978904 9.959373249962722e-08 7.0017679911593556 -0.6355583993430074 SS(ph)DEENGPPSS(ph)PDLDR ddPTM_A459_Selumetinib_30min_R2 1 SSDEENGPPSSPDLDR 16 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 2 S(0.337)S(0.663)DEENGPPS(0.261)S(0.739)PDLDR 161.95 0.00085837 0.0 16579.0 15561.0 18426.0 19358.0 20004.0 16858.0 21293.0 18325.0 17128.0 14693.0 True False 15657.605550995422 16754.47866349877 17240.491220711912 16721.40700558738 17490.918681970998 19180.03647831257 22283.166691279064 18378.322716132934 20554.078596305844 14268.774913001342 1.0973335585193522 1.1742058281564536 1.2082670955165757 1.171888063799455 1.2258178286934585 1.3441964425997226 1.5616734321721772 1.2880098556595128 1.4404935757713506 1.0 13.800573852918891 -6.658015597411347 3.2205183048876975 1.3604921135470542 1.1694378480500796 0.2246353988856895 0.13746461337187005 0.3102815862673579 6.394869535971886 0.04597423054571514 0.04531615344277712 2.197780939456483e-07 6.658015597411347 -0.19105426549697468 SS(ph)DGEDEQQVPK ddPTM_A459_Selumetinib_30min_R2 1 SSDGEDEQQVPK 12 0 Q16649 Q16649 NFIL3 Nuclear factor interleukin-3-regulated protein 1 S(0.226)S(0.774)DGEDEQQVPK 159.58 0.0004647 7047000.0 33086.0 26947.0 40223.0 41994.0 44041.0 37032.0 38218.0 43750.0 35371.0 45499.0 True False 31247.212573752022 29013.748251738427 37635.09597149113 36274.344756309394 38508.17584846452 42132.82185697418 39995.21272753033 43877.305256797605 42446.1883483147 44185.32564940097 0.7071852954460606 0.6566376466692799 0.8517555414237703 0.8209590904486448 0.871515039948259 0.9535478405497592 0.9051695815231036 0.9930288984391011 0.9606399347401926 1.0 15.43127969649816 -5.187376573751595 0.4143426431986275 0.9950418932336993 0.4999049625788844 0.8802685989820171 0.03840681210562778 1.1919222526587254 0.20661767092915603 0.030691100469952184 0.28299591730550633 6.49566211699573e-06 5.187376573751595 -0.4951369306548149 SS(ph)DKLNLVTK ddPTM_A459_Selumetinib_30min_R2 1 SSDKLNLVTK 10 1 A0A088AWN2;Q8TBZ3-4;Q8TBZ3-5;Q8TBZ3-6;Q8TBZ3;Q8TBZ3-2;Q8TBZ3-7 A0A088AWN2 WDR20 WD repeat-containing protein 20 1 S(0.124)S(0.876)DKLNLVTK 92.856 0.014319 22834000.0 143120.0 122550.0 152670.0 138860.0 133310.0 109960.0 131500.0 122880.0 112580.0 125150.0 True False 135165.963354754 131949.19093964205 142847.37841452757 119947.02845313921 116562.40599347906 125105.99188250375 137615.01056230682 123237.56045612099 135099.14574802158 121536.59432124934 1.11214210098301 1.0856745795498417 1.1753445882887659 0.9869210925566291 0.9590725052355642 1.0293689121469016 1.132292798978376 1.0139955059985932 1.1115923274180555 1.0 16.89103124503219 -5.764274113860857 24.999999976372447 1.0347691329858422 1.1205158366466996 0.37126659586523325 0.05421432048108507 87.1312243660902 768434.5651781188 0.015868700551511048 0.02474290948698328 1.7207821252577462e-06 5.764274113860857 0.08574670366085746 SS(ph)DTEENVK ddPTM_A459_Selumetinib_30min_R1 1 SSDTEENVK 9 0 H0YBT0;A0A087WUS5;P01106;P01106-2;A0A494C1T8 H0YBT0 MYC Myc proto-oncogene protein 1 S(0.203)S(0.797)DTEENVK 157.97 2.3271e-05 0.0 1373.2 1575.5 1087.1 1062.1 991.46 1211.7 1167.0 1439.6 1228.1 1370.4 True False 1405.1928882179334 1391.0397275699208 939.477791012863 876.6241730862238 901.7826180564801 1199.5113981355737 1078.9722504429103 1401.4171315201706 2083.996003124888 1546.3041888263956 0.9087428582111247 0.8995899627134061 0.6075633745297567 0.5669157332824395 0.5831857823142221 0.7757279627147434 0.6977748998156837 0.9063010639477149 1.3477270631379368 1.0 10.594608438687505 -8.016572674751348 4.035886766995498 1.1715169109658277 0.7157661047510314 0.6323902621115216 0.1374381663791378 0.1404446025309235 5.141266471746198 0.10001870591367869 0.03846435013364122 9.625589250783517e-09 8.016572674751348 -0.45575080621479624 SS(ph)EDLAGPLPSSVSSSSTTSSKPK ddPTM_A459_Selumetinib_30min_R1 1 SSEDLAGPLPSSVSSSSTTSSKPK 24 1 Q9NRF2-2;Q9NRF2-3;Q9NRF2 Q9NRF2-2 SH2B1 SH2B adapter protein 1 1 S(0.441)S(0.559)EDLAGPLPS(0.001)SVSSSSTTSSKPK 152.23 3.5672000000000004e-10 6320400.0 1156.8 968.21 964.73 788.59 1135.8 827.21 1079.9 982.41 536.18 717.01 True False 1183.751189259034 854.8515230913831 833.7249648825675 650.8775601676533 1033.0670905417774 818.8890184465864 998.4422735675221 956.3532954825861 909.85829896222 809.0452177688375 1.4631458950138168 1.0566177320086867 1.030504780909269 0.8045008435531273 1.2768966033700084 1.012167182329927 1.234099468903603 1.182076445764046 1.124607474315715 1.0 9.660076527322207 SS(ph)FMSR ddPTM_A459_Selumetinib_30min_R2 2 SSFMSR 6 0 Q16513-3;Q16513-2;Q16513;Q16513-4;B1AL79;Q16513-5;A0A3B3IUG4 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 S(0.227)S(0.773)FMSR;S(0.221)S(0.776)FMS(0.003)R 118.74 0.02108 13736600.0 54108.0 42660.0 50774.0 60543.0 54219.0 44729.0 43675.0 47005.0 40960.0 43960.0 True False 51100.89397148561 45931.884826480156 47507.25611855129 52296.938957499624 47407.52449599007 50890.013740564886 45705.97404037065 47141.776767903335 49153.14451802235 42690.76057820316 1.197001254589417 1.0759209769134879 1.1128229030149281 1.2250177380114688 1.1104867623322496 1.192061538640004 1.0706291811466808 1.1042618151894148 1.1513766410411232 1.0 15.381636245405726 -14.522872736039114 0.24007655026015284 0.2189628554266271 1.1491110749175288 0.41821267521284367 0.04951930954566843 171.91400734695668 1.7111853053927417 65.46136582363349 0.07710956474206786 3.0000415106549733e-15 14.522872736039114 0.9301482194909018 SS(ph)FSITR ddPTM_A459_Selumetinib_30min_R2 1 SSFSITR 7 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.016)S(0.636)FS(0.348)ITR 95.815 0.023547 2977800.0 26594.0 18309.0 23454.0 21300.0 15577.0 15359.0 21178.0 18327.0 12973.0 17123.0 True False 25116.01194421693 19713.241427286095 21944.995174784384 18398.90325545053 13620.07799985314 17474.562834879747 22162.81896341087 18380.32853580183 15567.96249590586 16628.614499103118 1.5104091772391253 1.1855011389162549 1.3197127864121219 1.1064603882928967 0.8190747341330062 1.0508730499358354 1.3328121212146837 1.105343354781193 0.9362152509305892 1.0 14.02138034742037 -4.019166862582917 0.7458716010355182 1.0611830824733606 2.4886557044429427 0.48469406765741985 0.14049013754153866 7.477815362467935 1.387258584809234 0.058450750504625545 11.647541814122063 9.568263733335225e-05 4.019166862582917 1.4274726219695821 SS(ph)FSQHAR ddPTM_A459_Selumetinib_30min_R1 2 SSFSQHAR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.096)S(0.904)FSQHAR;S(0.386)S(0.614)FSQHAR 107.79 0.0087003 5976700.0 5118.0 5882.599999999999 5447.6 5134.3 7365.2 6072.5 6441.799999999999 5522.599999999999 2346.59 3622.43 True False 5237.239442105583 5193.862457253455 4707.845841524856 4237.690887747479 6699.018960431677 6011.416163388855 5955.889839677067 5376.122708067025 3981.9918418474313 4087.4041759562206 1.2813118587374264 1.2706995035641138 1.1517935684506873 1.0367682532291047 1.6389421432404558 1.470717331735985 1.4571325915631348 1.3152902127202328 0.9742104451698543 1.0 11.996969193500762 -8.252582780636434 8.087851936294433 0.9862004371342816 1.3300331585941738 0.42087808312661845 0.15986476692294616 0.13672792941419445 84.02445923755793 0.13339447277999528 0.04490970872137415 5.59006965399505e-09 8.252582780636434 0.3438327214598922 SS(ph)FSQHAR ddPTM_A459_Selumetinib_30min_R2 1 SSFSQHAR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.114)S(0.871)FS(0.015)QHAR 91.584 0.016822999999999998 0.0 16659.0 12937.0 24523.0 29492.0 29114.0 15051.0 19141.0 28237.0 27846.0 36635.0 True False 15733.15947126079 13929.226300988601 22945.216878623592 25475.138723462296 25456.439037537657 17124.138630625366 20031.094427171953 28319.16499511301 33415.978082247326 35577.25236083878 0.4422252542632795 0.3915205749930544 0.6449406673090994 0.7160513258607835 0.7155257179320154 0.48132268498268155 0.5630309565226834 0.7959907838831585 0.9392512311892177 1.0 15.118667474795933 -6.8260567170611575 0.114523809767739 1.3087038590734492 2.935493263872264e-17 0.6626277611344089 0.113010526579371 11.932666050566949 0.6067077560028469 2.379120913195962 4.1675562299105975 1.4925994695394194e-07 6.8260567170611575 -1.3087038590734492 SS(ph)FSSDPDEK ddPTM_A459_Selumetinib_30min_R2 1 SSFSSDPDEK 10 0 P46013 P46013 MKI67 Antigen KI-67 1 S(0.014)S(0.986)FSSDPDEK 236.69 5.503200000000001e-09 13928000.0 136610.0 146290.0 142890.0 122700.0 123940.0 110740.0 140580.0 135800.0 130070.0 159970.0 True False 129017.76309315911 157509.97260351104 133696.61296686882 105988.04833069384 108369.54916234166 125993.42980236874 147117.24855398547 136195.15551709972 156087.63445945224 155351.25044802422 0.8304906637125815 1.0138957501099037 0.8606085408472436 0.6822477966867361 0.6975775788724584 0.8110229524320585 0.9469975177522398 0.87669172358974 1.0047401228461588 1.0 17.24517432843537 -7.757542836600519 1.3996194857466793 0.9902658488378661 0.8192693706067626 0.3588288299188612 0.09192149203928626 0.586623030462129 2.1254591394535334 0.08547748836671434 0.03325675335445172 1.7476608735299934e-08 7.757542836600519 -0.17099647823110342 SS(ph)GDGEELER ddPTM_A459_Selumetinib_30min_R2 2 SSGDGEELER 10 0 Q9BS91 Q9BS91 SLC35A5 Probable UDP-sugar transporter protein SLC35A5 1 S(0.153)S(0.847)GDGEELER;S(0.21)S(0.79)GDGEELER 103.21 0.011565 1503800.0 11503.400000000001 9536.0 12963.599999999999 12487.9 14819.3 10067.2 14207.3 14213.8 13396.6 10837.900000000001 True False 10864.087079758781 10267.380536927212 12129.53608970047 10787.026477170932 12957.567047777084 11453.865419057316 14867.96760123087 14255.159804778745 16076.294332278781 10524.981666754053 1.0322190977373276 0.9755247906378268 1.152451992198222 1.0248974125289565 1.2311249043508548 1.0882551420718753 1.412635961941415 1.3544118418569269 1.5274415520418456 1.0 13.361530099842922 -6.89366669864759 1.3124507518291808 1.3501540430920946 1.0523862292932027 0.3688497833157014 0.1458741043322848 0.4072773412131202 1.4552413514439293 0.07138160650478693 0.05714588105825726 1.2774187938059786e-07 6.89366669864759 -0.29776781379889194 SS(ph)GFISELPSEEGK ddPTM_A459_Selumetinib_30min_R2 1 SSGFISELPSEEGK 14 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(0.02)S(0.98)GFISELPSEEGK 275.19 5.707399999999998e-45 7832700.0 61978.0 58001.0 57826.0 51922.0 57124.0 45993.0 57060.0 46907.0 36546.0 51474.0 True False 58533.51087759182 62449.490197390405 54105.53811618839 44850.1340295541 49947.57242496054 52328.1182671153 59713.40306224499 47043.4916041281 43856.22118055776 49987.81187448658 1.170955652641137 1.249294335070989 1.082374604674454 0.8972213895292602 0.9991950147842623 1.0468175402137014 1.1945592500063458 0.9410992367949349 0.8773382857940549 1.0 15.60928875660254 -5.464370491706739 4.75305422564285 1.0010127684306434 1.2054859723964089 0.5029670779845289 0.0852528542413546 0.18674781262936146 8.634244526469113 0.02446230245069423 0.05143330752443535 3.432649874816239e-06 5.464370491706739 0.20447320396576552 SS(ph)GGGYGGGPAGGHGGNR ddPTM_A459_Selumetinib_30min_R1 1 SSGGGYGGGPAGGHGGNR 18 0 Q9H2U1-3;Q9H2U1-2;Q9H2U1 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 1 S(0.413)S(0.586)GGGYGGGPAGGHGGNR 141.3 0.00020569 818380.0 391.24 482.85 420.56 323.61 479.71 350.5 444.04 532.04 389.12 309.06 True False 400.35513077948195 426.3176975291251 363.4502619707196 267.0975884120447 436.32031519967944 346.9742882285374 410.54570530134504 517.928570890519 660.3082197996549 348.73086149933295 1.1480347023437951 1.2224834237389126 1.0422084825188747 0.7659132525973918 1.251166338774161 0.9949629543446675 1.1772565913330568 1.4851813477698468 1.8934608108979134 1.0 8.44597023316059 -7.704109924224986 3.740639530644202 1.5236811189969408 1.0723674295073267 0.3364786826226879 0.23941788886006923 0.22049656056165126 6.21287274120159 0.12377319693550284 0.06371857622038714 1.97646931288146e-08 7.704109924224986 -0.45131368948961414 SS(ph)GGGYGGGPAGGHGGNR ddPTM_A459_Selumetinib_30min_R2 2 SSGGGYGGGPAGGHGGNR 18 0 Q9H2U1-3;Q9H2U1-2;Q9H2U1 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 1 S(0.369)S(0.467)GGGY(0.164)GGGPAGGHGGNR;S(0.39)S(0.61)GGGYGGGPAGGHGGNR 203.17 1.0026e-29 0.0 10199.0 8044.9 9324.8 12233.2 11266.4 4556.4 11475.099999999999 15484.1 6847.9 13598.8 True False 9632.180409831852 8661.917961569394 8724.852520074595 10567.017056552937 9851.014109106078 5184.00274111896 12008.714887479284 15529.156167469248 8217.671346312625 13206.167310074361 0.7293698605865697 0.6558994565335868 0.6606649995581093 0.800157745123512 0.7459404290290343 0.39254407576408107 0.9093262720000831 1.1759018194190822 0.6222601269062942 1.0 13.688924208356584 -7.490961394821286 24.71928230490234 0.9479714280962287 0.6715942377110966 0.3844196431279445 0.16259637412739011 558.4322702323954 432494.69885030465 0.06562934002088466 0.0441977480833087 3.2287811208284026e-08 7.490961394821286 -0.2763771903851321 SS(ph)GGREDLESSGLQR ddPTM_A459_Selumetinib_30min_R1 1 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 S(0.132)S(0.867)GGREDLESSGLQR 120.66 0.0083799 6757500.0 1527.6 1955.2 2031.5 2742.8 2187.4 1699.7 1810.6 2032.1 1172.6 1607.7 True False 1563.1901078078322 1726.2842750521795 1755.6334582307343 2263.8214687326 1989.5500562168363 1682.6025612041221 1674.0249842775772 1978.202106808931 1989.8165566845087 1814.063955324136 0.8617061726076367 0.9516115845781897 0.9677902772270444 1.2479281461320373 1.0967364465721632 0.927532106167379 0.9228037299150588 1.0904809066973975 1.0968833545501813 1.0 10.825009604035955 -5.277135127187146 2.71410796879354 1.050849697401106 0.8915693919105858 0.290040169365403 0.09208642259303983 0.392295177046054 5.628875241630641 0.027361364457269374 0.08361162971980042 5.282808559201623e-06 5.277135127187146 -0.15928030549052008 SS(ph)GGREDLESSGLQR ddPTM_A459_Selumetinib_30min_R2 1 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 S(0.27)S(0.73)GGREDLESSGLQR 107.46 0.02009 17839000.0 38502.0 43064.0 37702.0 43808.0 46891.0 29062.0 31874.0 40256.0 27582.0 38917.0 True False 36362.21297571783 46366.8703274154 35276.294366833856 37841.27482698485 41000.13336914127 33065.02670143077 33356.204157132815 40373.13829526042 33099.17070547103 37793.36509149073 0.9621321861044038 1.22685212642933 0.9333991371616814 1.0012676758308805 1.0848500330649984 0.8748897226110052 0.8825941822429316 1.0682599497960696 0.875793161718838 1.0 15.205845360297776 -5.2973219923969666 24.978823537404384 0.9669651037116329 1.0944923534519568 0.2361892270243372 0.09300491551287245 708.6370881100916 493299.60936426086 0.023479653670639426 0.04887892228871899 5.042872728323227e-06 5.2973219923969666 0.12752724974032392 SS(ph)GPYGGGGQYFAKPR ddPTM_A459_Selumetinib_30min_R2 1 SSGPYGGGGQYFAKPR 16 1 F8W6I7;P09651-2;P09651;P09651-3;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 S(0.203)S(0.797)GPYGGGGQYFAKPR 76.051 0.01645 96500000.0 50674.0 56321.0 54062.0 57705.0 69162.0 45000.0 41169.0 44129.0 34613.0 51881.0 True False 47857.74194409445 60640.63959944182 50583.70977825504 49845.47945332266 60473.25124387513 51198.3415306718 43083.44007482591 44257.40808405077 41536.567168025125 50383.06072697359 0.9498776226286871 1.2035918168619046 1.0039824704649996 0.989330118776148 1.2002695027120405 1.0161816450198655 0.8551175623945434 0.8784184097882062 0.8244153207188479 1.0 15.620651146748614 -7.13711946958585 4.448258982597005 0.8801494916025773 1.0718596794624808 0.47590973885282584 0.08879513728191495 0.18740181343187817 5.938673536323486 0.03365830863880676 0.025798412592216234 7.292568721975493e-08 7.13711946958585 0.19171018785990357 SS(ph)GSETEQVVDFSDR ddPTM_A459_Selumetinib_30min_R2 1 SSGSETEQVVDFSDR 15 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 S(0.211)S(0.692)GS(0.097)ETEQVVDFSDR 149.31 0.00028779 15040000.0 24791.0 29245.0 33206.0 26759.0 31377.0 25230.0 25892.0 21106.0 24127.0 27486.0 True False 23413.215466236048 31487.9974625038 31069.562111959174 23114.378038150284 27435.140746060973 28705.20348486335 27096.029304024665 21167.414965713597 28953.074164705213 26692.40776279554 0.8771488759762578 1.1796611883920212 1.1639849948367942 0.8659532794327984 1.0278256270421835 1.0754070498231068 1.015121211425209 0.7930125732312991 1.084693236443834 1.0 14.704141827808296 -7.543060555772538 24.927197029417513 0.9441251238467288 1.0374123902068593 0.06516303751489394 0.11772419661866032 536.143913518297 662200.1865703706 0.05465743713801072 0.03156126715864804 2.8637786316108394e-08 7.543060555772538 0.09328726636013052 SS(ph)GSPYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 S(0.02)S(0.49)GS(0.49)PYGGGYGSGGGSGGYGSR 212.55 1.0021e-23 126790000.0 1216.4 1662.5 1707.8 1903.5 1503.0 1248.6 1751.8 1392.6 876.65 1190.9 True False 1244.7397532976227 1467.8537271247183 1475.8901402739093 1571.089458120352 1367.0539153762018 1236.040217638094 1619.6603156177277 1355.6637241976864 1487.6110220172907 1343.763615348333 0.9263085702576929 1.09234519402002 1.098325719952855 1.169171006102209 1.0173321406844547 0.9198345628056653 1.2053163942810554 1.0088558052275205 1.107048148220377 1.0 10.392063657184469 -10.818502475448309 5.357183357511791 0.9999893724360499 1.063082160227335 0.03896855965944013 0.08931814667244327 1.1109284394430521e-05 1.4606093832791796e-06 0.08474243944754732 0.020549598847088405 1.5187892850139627e-11 10.818502475448309 0.06309278779128513 SS(ph)GSPYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R2 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 S(0.004)S(0.888)GS(0.108)PYGGGYGSGGGSGGYGSR 227.36 2.0437999999999998e-57 0.0 6528.9 4832.3 7264.4 6319.3 6384.3 5256.2 6377.0 7085.4 4405.3 4074.5 True False 6166.049875257492 5202.921871706518 6797.01641288069 5458.600438599466 5582.247157633844 5980.193838967048 6673.543135785778 7106.017340948882 5286.483094366308 3956.8585981776323 1.5583194906427345 1.3149122574414893 1.7177809730201425 1.3795288113437953 1.4107775193697343 1.5113488871503473 1.686576098235944 1.795873459875878 1.3360303289081512 1.0 11.95013979491763 -6.988977429877068 23.256096851156197 1.5320884390908485 1.4739152722037765 0.0 0.22798630534970696 622.1662009295607 1312667.2692231531 0.0772772062158162 0.0680633244733041 1.0257052303861835e-07 6.988977429877068 -0.05817316688707197 SS(ph)HGANK ddPTM_A459_Selumetinib_30min_R1 1 SSHGANK 7 0 G3V5X4;A0A0A0MRE3 G3V5X4 SYNE2 1 S(0.011)S(0.989)HGANK 87.58200000000002 0.033402 21539000.0 1237.3 1476.5 1140.2 1124.8 792.28 1304.4 992.86 882.99 644.32 593.18 True False 1266.1266826333008 1303.630693593773 985.3671026702846 928.3747951109913 720.6184138883947 1291.2789203004395 917.9677708438282 859.5702368442594 1093.3639807291174 669.3204310624942 1.8916599940381664 1.9476929630317135 1.4721903843665594 1.3870408731394444 1.076641889960641 1.9292387627412397 1.3714922303904957 1.2842432368002847 1.6335434120746726 1.0 9.386553243137639 -5.305047043216773 4.524206227323784 1.4069560931059433 1.9244511124153025 0.4171343689101983 0.24876647323706844 0.18626201858745475 8.74183022650899 0.06395478525394548 0.14797452291443008 4.953965260464445e-06 5.305047043216773 0.5174950193093593 SS(ph)IDSQASLSGPLSGGAPGAGAR ddPTM_A459_Selumetinib_30min_R1 2 SSIDSQASLSGPLSGGAPGAGAR 23 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(0.212)S(0.777)IDS(0.011)QASLSGPLSGGAPGAGAR;S(0.014)S(0.986)IDSQASLSGPLSGGAPGAGAR 340.33 7.070699999999994e-184 29159000.0 1829.02 2472.02 1755.31 1875.5300000000002 2313.57 1651.15 2392.3 1945.8000000000002 1269.72 2079.57 True False 1871.6326073466107 2182.5947491890793 1516.9485432276585 1548.0038935584269 2104.3080019939584 1634.5409301242487 2211.8468849482215 1894.1910631508385 2154.622103320359 2346.5030662271674 0.7976263207513814 0.9301478359874344 0.6464720055391571 0.6597067422747459 0.8967846802678067 0.6965858914270888 0.9426141038479642 0.8072399693030957 0.9182268433105759 1.0 11.196296630230837 -8.22569720602346 0.6931757157037454 0.9965858506983303 0.7727489538132775 0.3461688057505341 0.09767027234927546 0.8043874076649655 0.865919704045909 0.09595446920377282 0.04106949168949985 5.947066488721136e-09 8.22569720602346 -0.22383689688505282 SS(ph)IDSQASLSGPLSGGAPGAGAR ddPTM_A459_Selumetinib_30min_R2 2 SSIDSQASLSGPLSGGAPGAGAR 23 0 A6NKD9 A6NKD9 CCDC85C Coiled-coil domain-containing protein 85C 1 S(0.002)S(0.997)IDS(0.002)QASLSGPLSGGAPGAGAR;S(0.042)S(0.958)IDSQASLSGPLSGGAPGAGAR 449.83 0.0 24830000.0 39696.0 33386.0 42530.0 45769.0 54395.0 39906.0 39995.0 48553.0 39942.0 47964.0 True False 37489.855235678544 35946.59884709015 39793.666103162795 39535.18324407115 47561.413802530085 45402.689269399765 41854.846748589014 48694.28119161814 47931.51607272581 46579.15469456181 0.8048633660596581 0.7717314554720113 0.8543234922167613 0.848774167399971 1.0210879547816902 0.9747426626164301 0.8985746311423645 1.0454092932970995 1.0290336178711696 1.0 15.507396837710736 -6.09960379620009 2.619059903542828 0.9918628253746566 0.8062981684336163 0.7974279262656513 0.04318923692440697 0.13246548649535908 1.7759112565043098 0.014393945328880806 0.020249140075291397 7.950532254351776e-07 6.09960379620009 -0.1855646569410403 SS(ph)ISGSLPSSGSLQAVSSR ddPTM_A459_Selumetinib_30min_R1 1 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.025)S(0.971)IS(0.003)GS(0.001)LPSSGSLQAVSSR 173.49 1.3995e-09 2964000.0 1640.0 1502.4 1358.0 1390.4 1050.6 1372.2 1594.3 1362.4 949.24 1222.8 True False 1678.208809115504 1326.4983095531893 1173.5910589600478 1147.5927410404722 955.5734154984954 1358.396913857914 1474.0406674217068 1326.2647263011122 1610.790950253455 1379.7582910806466 1.2163063776925063 0.9613990494771781 0.8505772833884364 0.8317346222588459 0.692565807848907 0.9845180294542734 1.0683325311038478 0.9612297565991522 1.1674442985168514 1.0 10.430199839490477 -6.993446869380098 24.989343847409785 1.0432214600483902 0.8989272141072011 0.1906218085138751 0.1336871225718948 285.196391188894 1087545.438795656 0.04977431420145022 0.04379248014237236 1.0152035567186071e-07 6.993446869380098 -0.14429424594118911 SS(ph)ISGSLPSSGSLQAVSSR ddPTM_A459_Selumetinib_30min_R2 1 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.033)S(0.967)ISGSLPSSGSLQAVSSR 216.53 4.9012e-19 2915100.0 11512.0 7194.1 8860.2 8430.9 9826.8 6916.7 9437.8 8803.0 6484.9 6684.7 True False 10872.209126187305 7745.8643373225705 8290.14437825636 7282.596875886285 8592.269531293363 7869.412641448839 9876.67640064591 8828.615272584897 7782.061203245201 6491.695342063571 1.6747873326309337 1.1931959109560317 1.2770384223886115 1.12183281749191 1.3235786768394564 1.2122276580754205 1.521432519583756 1.3599860756525382 1.19877178351556 1.0 12.664379579864127 -8.57565579760169 3.5385345559518266 1.0004035485644194 1.3224695559119706 0.31211448085682914 0.1538082916840004 0.338429778063373 11.777518768355081 0.14666481991790786 0.038656074507131245 2.6567103176706203e-09 8.57565579760169 0.3220660073475512 SS(ph)ITEPEGPNGPNIQK ddPTM_A459_Selumetinib_30min_R1 2 SSITEPEGPNGPNIQK 16 0 Q13625-2;Q13625;Q13625-3 Q13625-2 TP53BP2 Apoptosis-stimulating of p53 protein 2 1 S(0.014)S(0.986)ITEPEGPNGPNIQK;S(0.184)S(0.816)ITEPEGPNGPNIQK 350.86 3.2482999999999977e-174 23679600.0 5659.4 5716.5 4144.4 3775.4 4526.4 4120.5 5075.8 6110.2 3048.8 4899.8 True False 5791.253008724568 5047.2095224712475 3581.61324355966 3116.0972630352403 4116.987919200827 4079.0515111146583 4692.928319449975 5948.137647273229 5173.590924458238 5528.737058093676 1.0474820827745077 0.9129046054166192 0.6478176129422604 0.5636182785132631 0.7446525085098504 0.7377908314780893 0.8488246538293702 1.0758582990604664 0.9357636057016803 1.0 12.43273424466715 -7.579955326950549 4.638697905216513 1.0025971691622027 0.7666217630778861 0.38169525732864973 0.1292981040033683 0.23430796841964446 10.441574507860736 0.07002530376810212 0.03962395343053814 2.6305385643767566e-08 7.579955326950549 -0.23597540608431655 SS(ph)LAELMAR ddPTM_A459_Selumetinib_30min_R2 1 SSLAELMAR 9 0 Q9ULE0 Q9ULE0 WWC3 Protein WWC3 1 S(0.252)S(0.748)LAELMAR 97.813 0.020257 834710.0 12310.0 9832.6 12040.0 9613.9 12719.0 9125.7 7644.4 10613.0 7657.7 10910.0 True False 11625.859480834404 10586.728803207898 11265.359508160833 8304.470235097455 11121.125510697311 10382.682340143376 7999.879747091238 10643.882072923268 9189.453974015132 10594.999952415757 1.097296794058371 0.9992193346630479 1.063271312766002 0.7838103135813568 1.0496579103958932 0.9799605839333703 0.755061801134524 1.0046136970955215 0.8673387461337224 1.0 13.371095960780103 -5.692274245731738 24.999978781872905 0.9212719654178833 1.0478592770773218 0.2979742990952239 0.09356775081513745 65.03215194520425 23504.680552674898 0.024569933337083034 0.04255636308827094 2.0310740351789707e-06 5.692274245731738 0.1265873116594386 SS(ph)LETLEDIEENAPLR ddPTM_A459_Selumetinib_30min_R1 2 SSLETLEDIEENAPLR 16 0 V9GYB4;Q8TDN4-2;Q8TDN4 V9GYB4 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 S(0.212)S(0.787)LET(0.001)LEDIEENAPLR;S(0.022)S(0.978)LETLEDIEENAPLR 242.93 1.0314000000000002e-21 4384900.0 914.8 1029.48 735.173 1111.69 986.0999999999999 667.47 854.4 810.18 581.49 985.87 True False 936.113060109063 908.9480030077322 635.3405446162257 917.5542105058126 896.9074291100948 660.7558578142704 789.9519201186133 788.6913945644707 986.7460596507548 1112.4160176870107 0.8415134672867033 0.817093594982263 0.5711357392509113 0.8248300958607516 0.8062697901231125 0.5939826893073205 0.7101227486467874 0.7089896064283181 0.8870297118720432 1.0 10.119480707986154 -8.464826282468058 3.16256717680847 0.9984312123712518 0.7316457348714652 0.4872813536286943 0.08935202072278231 0.19205705599442718 4.0724176425699765 0.08743247327567825 0.02330003561109379 3.4290492088021373e-09 8.464826282468058 -0.26678547749978654 SS(ph)LGSHQLPR ddPTM_A459_Selumetinib_30min_R1 4 SSLGSHQLPR 10 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 S(0.3)S(0.697)LGS(0.003)HQLPR;S(0.217)S(0.778)LGS(0.004)HQLPR;S(0.372)S(0.591)LGS(0.037)HQLPR;S(0.235)S(0.763)LGS(0.002)HQLPR 91.093 0.018863 30686900.0 9324.1 10336.3 10115.6 11780.7 12036.500000000002 9511.1 10124.3 9635.1 4174.1 7259.200000000001 True False 9541.333388459681 9126.121190784494 8741.95708101344 9723.421896127365 10947.80070021667 9415.426969387852 9360.615899879302 9379.54584878438 7083.142835798064 8190.989030595866 1.164857302679794 1.1141659641705808 1.0672651432396671 1.187087647145832 1.336566397454967 1.1494859697917228 1.1427943395986149 1.1451054095847142 0.8647481774594429 1.0 12.99982194695425 -8.207609444803236 7.071842394735242 0.9330508181425213 1.1645721068826265 0.6204342835742778 0.07230159785097716 0.15342768160816034 17.322891620479876 0.05367032962920071 0.019758156263907877 6.1999838067018015e-09 8.207609444803236 0.23152128874010514 SS(ph)LGSHQLPR ddPTM_A459_Selumetinib_30min_R2 1 SSLGSHQLPR 10 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 S(0.193)S(0.807)LGSHQLPR 106.26 0.0079448 23618000.0 76889.0 56268.0 76460.0 99921.0 99913.0 74264.0 59352.0 72524.0 74581.0 83672.0 True False 72615.8171910542 60583.57466986373 71540.64684335374 86311.5874266608 87361.03570644716 84493.1918985291 62111.985603756824 72735.03283300542 89499.28396725167 81256.17195403583 0.8936652496025875 0.7455873592486493 0.8804333889101018 1.0622157720583325 1.0751310774997458 1.039837219335466 0.7643971419043922 0.8951324075929818 1.1014459802250927 1.0 16.310189779153937 -5.553793835192203 7.120911333143141 0.9824299656430019 0.8177334133819802 0.3356491717162291 0.09943794633292474 0.21518440127671884 36.317299192484995 0.02911516098717527 0.051476967969946524 2.793869810047735e-06 5.553793835192203 -0.16469655226102164 SS(ph)LSASHPMVGK ddPTM_A459_Selumetinib_30min_R1 4 SSLSASHPMVGK 12 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.013)S(0.852)LS(0.132)AS(0.003)HPMVGK;S(0.23)S(0.769)LS(0.001)ASHPMVGK;S(0.007)S(0.993)LSASHPMVGK;S(0.079)S(0.921)LSASHPMVGK 168.83 0.0003725 159247500.0 23661.1 24240.4 25246.699999999997 26467.7 28086.0 23285.300000000003 28603.299999999996 22691.2 8486.400000000001 15173.3 True False 24212.35759351395 21402.322698943783 21818.336810196324 21845.613055262435 25545.626258986027 23051.07102336081 26445.73005235106 22089.355664594663 14400.80097786749 17120.940855457946 1.4141955046702557 1.2500669723487179 1.2743655266609315 1.2759586777205834 1.4920690676203343 1.3463670728126143 1.5446423345315445 1.2901951972781243 0.8411220562844647 1.0 14.063474364594972 -8.180836000484394 5.063176545394696 0.9227797521124183 1.365400479302609 0.7668968749852646 0.09763932219377365 0.0974074293345252 4.266288839192134 0.07303464651196445 0.0258388458824666 6.594228613673152e-09 8.180836000484394 0.44262072719019085 SS(ph)LSASHPMVGK ddPTM_A459_Selumetinib_30min_R2 1 SSLSASHPMVGK 12 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.205)S(0.795)LSASHPMVGK 160.56 0.00017556 0.0 38022.0 37188.0 50483.0 69461.0 64226.0 55609.0 46467.0 51803.0 50573.0 57210.0 True False 35908.88945412557 40040.20002173333 47234.97874173446 60000.29197309156 56157.35569227502 63268.63498175842 48627.80757261374 51953.73815355168 60689.01312768419 55558.198650568775 0.6463292606006397 0.7206893130852691 0.8501891689976687 1.0799538759429759 1.0107843136793297 1.1387812513448132 0.875258895243464 0.9351227976326733 1.0923502669585363 1.0 15.761712203490408 -5.43068965695036 2.4156899125425415 1.01461940899864 0.6709060973940131 0.7633744288068867 0.07493216623484873 0.14511938923668755 1.629346426982549 0.02177142183369683 0.05712460483596811 3.709457016588362e-06 5.43068965695036 -0.3437133116046269 SS(ph)LSGDEEDELFK ddPTM_A459_Selumetinib_30min_R1 1 SSLSGDEEDELFK 13 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 S(0.3)S(0.7)LS(0.001)GDEEDELFK 307.77 1.1861999999999994e-87 81792000.0 2759.8 2461.0 2714.9 2842.9 2417.8 2648.2 2548.9 2271.4 1659.2 2325.3 True False 2824.0979703640055 2172.8649759121404 2346.2314918782276 2346.4408828423157 2199.1104168972606 2621.561512373216 2356.6344208688365 2211.1550934529823 2815.5412168266566 2623.7749053400607 1.0763491809515502 0.8281445833976833 0.8942198079198942 0.8942996131515327 0.8381475150255847 0.999156408973064 0.8981846789038479 0.8427381056784672 1.0730879432897624 1.0 11.357428240563534 -8.268496650544968 24.994630640604008 1.0365439823374396 0.9055290759248522 0.31922235740446514 0.07442835334904369 673.3734556599098 2384844.516976782 0.06306767518823385 0.01769267257901675 5.388940015261737e-09 8.268496650544968 -0.1310149064125874 SS(ph)LSGDEEDELFK ddPTM_A459_Selumetinib_30min_R2 3 SSLSGDEEDELFK 13 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 S(0.148)S(0.532)LS(0.32)GDEEDELFK;S(0.103)S(0.896)LS(0.001)GDEEDELFK;S(0.233)S(0.767)LSGDEEDELFK 132.06 0.0014615 8160900.0 66283.0 55468.0 56771.0 70067.0 62364.0 43280.3 55016.0 56564.0 44961.0 56580.0 True False 62599.25621187218 59722.2172422691 53118.41566759126 60523.753727683245 54529.2767787662 49241.76846555415 57574.353012135885 56728.59187532568 53954.45631530282 54946.388387505365 1.1392788142943178 1.0869179757745413 0.9667317038742844 1.1015055857874392 0.9924087529502846 0.8961784370299318 1.0478277954521231 1.032435316316906 0.9819472744012397 1.0 15.745737035852748 -4.220800992111846 0.858399984361135 0.9990693123325622 1.408744050804545 0.4233913969724302 0.051976002538513616 5.439573277983933 1.584352321750616 0.018704654087729655 2.6426586573516593 6.0144927801204875e-05 4.220800992111846 0.40967473847198277 SS(ph)LYEGLEKPESR ddPTM_A459_Selumetinib_30min_R2 1 SSLYEGLEKPESR 13 1 P20020-6;P20020;P20020-4;P20020-1;A0A0U1RQU3;E7ERY9;H0YHH6;A0A2R8Y4R4;Q01814-6;Q01814-8;Q01814-5;Q01814 P20020-6;Q01814-6 ATP2B1;ATP2B2 Plasma membrane calcium-transporting ATPase 1;Calcium-transporting ATPase;Plasma membrane calcium-transporting ATPase 2 1 S(0.236)S(0.76)LY(0.003)EGLEKPESR 71.031 0.032497000000000005 3285900.0 15820.0 6226.6 8648.4 11384.0 10988.0 6831.6 16553.0 12971.0 9255.4 8261.4 True False 14940.787732477678 6704.160198325391 8091.97135966595 9833.479561504642 9607.589206033654 7772.590888909722 17322.747299147242 13008.743462535353 11106.738617483015 8022.871916304997 1.8622742439790547 0.8356309646051349 1.008612806496452 1.2256807367845324 1.1975249394805882 0.9688040604404233 2.1591703669033997 1.621457203635209 1.3843843867070385 1.0 12.969903049739061 -7.2158059938468835 24.99998966213727 1.593042854310823 1.1619560209102007 0.1758969425461 0.3714334481656469 615.3949219125703 337140.9085187309 0.1371173306095169 0.10621020915996894 6.08406725404178e-08 7.2158059938468835 -0.43108683340062237 SS(ph)LYFPR ddPTM_A459_Selumetinib_30min_R1 2 SSLYFPR 7 0 B8ZZW8;E7ENZ2;E9PG19;O94868-2;O94868 B8ZZW8 FCHSD2 F-BAR and double SH3 domains protein 2 1 S(0.201)S(0.798)LYFPR;S(0.225)S(0.775)LYFPR 115.49 0.013004 8085400.0 4171.2 4754.4 4403.7 4669.2 4480.6 4442.9 4471.6 4217.7 3007.1 3418.3 True False 4268.380844257681 4197.752637739405 3805.7017277926057 3853.8118717391912 4075.3305211141796 4398.208459830435 4134.303611894187 4105.832894979591 5102.829070105735 3857.0721020616375 1.1066375559783277 1.0883262035717898 0.986681510505968 0.9991547395962073 1.0565865540693111 1.1402971848723167 1.071876154372216 1.064494721990027 1.322979953467354 1.0 11.913290399857306 -6.671366321279916 5.589003654346873 1.1207778680688143 1.0424031776154579 0.15299369583753353 0.08525630939179861 0.39949333741068904 19.577763448828765 0.02830451097916935 0.02811615401617828 2.1312464783828878e-07 6.671366321279916 -0.07837469045335643 SS(ph)LYFPR ddPTM_A459_Selumetinib_30min_R2 1 SSLYFPR 7 0 B8ZZW8;E7ENZ2;E9PG19;O94868-2;O94868 B8ZZW8 FCHSD2 F-BAR and double SH3 domains protein 2 1 S(0.179)S(0.811)LY(0.01)FPR 91.069 0.034169 0.0 12258.0 8986.1 10825.0 13488.0 13444.0 11177.0 9743.0 8899.6 10881.0 12842.0 True False 11576.74943266192 9675.304975134395 10128.531285368852 11650.9111319022 11755.044529115079 12716.53029529598 10196.06880538825 8925.496362591914 13057.504040542026 12471.218092476913 0.9282773620682194 0.7758107430557154 0.8121525267430569 0.9342239904320532 0.9425738882881172 1.0196702680524083 0.8175679977514695 0.7156876173928908 1.0470111214251623 1.0 13.606314762932868 -14.522878745263204 0.17774952091362403 1.4774126557365506 0.8572834591671222 0.12030025636166575 0.09997484844149301 325.19722376667625 3.108114089493288 54.73046167578389 0.33634192913775035 3.0000000001183515e-15 14.522878745263204 -0.6201291965694283 SS(ph)LYGIAK ddPTM_A459_Selumetinib_30min_R2 2 SSLYGIAK 8 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.386)S(0.614)LYGIAK;S(0.158)S(0.842)LYGIAK 118.71 0.0050723 10555000.0 219480.0 184808.0 221525.0 287970.0 248880.0 200184.0 266770.0 235600.0 197271.0 228216.0 True False 207282.1802480533 198982.17934862015 207272.32267818283 248747.98922404234 217613.46938457 227757.5289105782 279175.33359472634 236285.55699432036 236730.7122122746 221626.81110362124 0.9352757422076469 0.897825395572679 0.9352312639704634 1.1223731821315637 0.9818914431017337 1.0276623472423223 1.2596640821773066 1.0661415729338155 1.0681501531039561 1.0 17.757772895113114 -5.703837354357373 6.7742522297139764 1.0796011616988344 0.9181973804230494 0.4735793133168419 0.07352084679998082 0.18431099654996203 16.88911258894825 0.020800641698163015 0.036001875084167925 1.9777101646378596e-06 5.703837354357373 -0.16140378127578492 SS(ph)MEMEGIFNHK ddPTM_A459_Selumetinib_30min_R1 1 SSMEMEGIFNHK 12 0 E7EPJ7;O75962-5;O75962-4;O75962;E7EWP2;O75962-2 E7EPJ7 TRIO Triple functional domain protein 1 S(0.044)S(0.956)MEMEGIFNHK 108.23 0.01524 5414700.0 2282.6 2705.0 2456.1 2654.4 2911.2 2292.5 2620.0 2574.0 1543.2 1876.6 True False 2335.7801388335674 2388.297342479617 2122.5751103915836 2190.858869259081 2647.882474014105 2269.4395314234584 2422.3712906258975 2505.729158469656 2618.697689131446 2117.479889631944 1.1030943671628295 1.1278961156484684 1.0024062664229247 1.0346539204393066 1.2504876608175743 1.0717643848877014 1.1439878614606107 1.1833544066882244 1.236704868817726 1.0 11.048132552559094 -6.226808068940663 24.997552920507932 1.152900258053405 1.0667467371790074 0.21129504764838758 0.07599011319171874 936.5567492374938 676024.2678184309 0.022026972022096546 0.028435334764506652 5.931874184829275e-07 6.226808068940663 -0.08615352087439754 SS(ph)MEMEGIFNHK ddPTM_A459_Selumetinib_30min_R2 3 SSMEMEGIFNHK 12 0 E7EPJ7;O75962-5;O75962-4;O75962;E7EWP2;O75962-2 E7EPJ7 TRIO Triple functional domain protein 1 S(0.225)S(0.775)MEMEGIFNHK;S(0.407)S(0.593)MEMEGIFNHK;S(0.099)S(0.901)MEMEGIFNHK 206.45 6.8265e-06 24790200.0 93452.0 82522.0 84822.0 106449.0 98807.0 83720.0 88901.0 74309.0 69579.0 88419.0 True False 88258.31195799643 88851.17204994836 79364.64486721087 91950.46256523277 86393.98131421261 95251.6700655076 93035.07265398951 74525.22688748283 83496.74419969434 85866.11372984857 1.0278596308163448 1.034764101814266 0.9242836483424348 1.0708585560833315 1.0061475658025565 1.1093045431773914 1.083489966096473 0.8679236039720353 0.9724062330617556 1.0 16.389801276930136 -7.752507356558204 24.999888937199092 0.9401236797998056 1.0352108613404956 0.3436167546020611 0.05668816385902557 202.9524577222926 568048.8808243844 0.02758948399017128 0.01562753305924552 1.7680422684336532e-08 7.752507356558204 0.09508718154068996 SS(ph)PAELSSSSQHLLR ddPTM_A459_Selumetinib_30min_R2 2 SSPAELSSSSQHLLR 15 0 Q9UQC2;Q9UQC2-2;E9PJE2 Q9UQC2 GAB2 GRB2-associated-binding protein 2 1 S(0.172)S(0.828)PAELSSSSQHLLR;S(0.226)S(0.774)PAELSSSSQHLLR 229.02 5.6342999999999986e-14 9474500.0 27608.0 21153.0 52047.0 71650.0 86410.0 48163.0 32477.0 42764.0 57254.0 67831.0 True False 26073.65788358053 22775.36708238477 48698.352684488935 61891.146396855955 75554.40328479862 54797.01606981662 33987.24485195464 42888.4361600387 68706.3998104211 65872.54278389683 0.3958198178126879 0.34574901954373055 0.7392815067766552 0.939559090650222 1.1469786969157143 0.8318642905525164 0.5159546514464164 0.6510821405625651 1.0430203071987232 1.0 16.007389621049136 -5.353318136497258 3.6780291373136462 0.8545737993299429 0.36639141713812545 0.5583438332628592 0.17594626291411042 0.189513698636031 4.725936792432867 0.05224189084315843 0.12292701120152556 4.432838034651141e-06 5.353318136497258 -0.4881823821918175 SS(ph)PELEDTATSSK ddPTM_A459_Selumetinib_30min_R1 1 SSPELEDTATSSK 13 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 S(0.029)S(0.971)PELEDTATSSK 167.22 0.00031163 3072900.0 1016.8 3124.1 1014.2 1157.3 1030.2 1085.8 1615.9 974.0 498.5 1443.1 True False 1040.4894616516133 2758.328919645313 876.4772106018264 955.1992802115486 937.018591896582 1074.8778378275204 1494.0113620314467 948.1663560021154 845.918091000535 1628.3359419843646 0.6389894338287622 1.6939556810886869 0.5382655925003481 0.5866106959768382 0.5754455009785563 0.6601081571150638 0.9175080666774303 0.5822916092158702 0.5194985071505949 1.0 10.669182657384269 -5.299742220691497 24.999920891591803 0.6593266816742293 1.1664734701035946 0.32952595748873925 0.28136445333435084 484.8381812455754 316448.7084220032 0.0681636618761373 0.1418983869761941 5.014848060213706e-06 5.299742220691497 0.5071467884293653 SS(ph)PELTR ddPTM_A459_Selumetinib_30min_R1 3 SSPELTR 7 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.111)S(0.889)PELTR;S(0.23)S(0.77)PELTR;S(0.107)S(0.893)PELTR 176.44 8.3081e-07 234692000.0 8437.8 9247.0 7063.0 7589.099999999999 7924.4 6768.9 7784.8 7760.2 4220.5 7298.0 True False 8634.384322899268 8164.35694118633 6103.8833942818965 6263.806150050521 7207.639419166455 6700.8110116694625 7197.586268421562 7554.374287317888 7161.880246876143 8234.769388539875 1.0485277626493739 0.9914493722858182 0.741233069960225 0.7606534991456719 0.8752691276573147 0.8137217565551763 0.8740483101370471 0.9173753302467855 0.8697123026715423 1.0 13.007512533075351 -10.075815546082168 11.82369341566072 0.9999989514292376 0.8720506488210474 0.14313569988285313 0.0896655978092345 0.0 0.0 0.09353550438470642 0.022685692019033442 8.398165983962015e-11 10.075815546082168 -0.12794830260819012 SS(ph)PELTR ddPTM_A459_Selumetinib_30min_R2 2 SSPELTR 7 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.086)S(0.914)PELTR;S(0.079)S(0.921)PELTR 159.28 0.00095488 211955000.0 119721.0 102420.0 123051.0 116067.0 132951.0 97492.0 116210.0 170030.0 102636.0 116246.0 True False 113067.38610113531 110275.28466779419 115134.0326277988 100258.47437325711 116248.50678297976 110920.63805573908 121613.99526574646 170524.75915001822 123166.0678894468 112889.67593662004 1.0015741932381403 0.9768411836854447 1.0198809738141053 0.8881102150523091 1.029753215415779 0.9825578569116769 1.077281817462427 1.5105434375217481 1.0910303964252344 1.0 16.78455402825287 -7.5328939006377915 24.998110901686903 1.2392547176805677 0.9862740690075502 0.35282820938110904 0.12876479513569822 186.35598391478163 465143.21054217266 0.05613687653120121 0.03245687370725357 2.93160935817599e-08 7.5328939006377915 -0.2529806486730175 SS(ph)PGAGPSDHHSASR ddPTM_A459_Selumetinib_30min_R2 1 SSPGAGPSDHHSASR 15 0 I3VM54;Q9Y2K7-3;Q9Y2K7;Q9Y2K7-4;Q9Y2K7-5;Q9Y2K7-2 I3VM54 KDM2A Lysine-specific demethylase 2A 1 S(0.222)S(0.778)PGAGPSDHHSASR 146.67 0.00022422 1893400.0 1036.3 369.89 2548.4 6273.6 9149.6 4046.0 1695.9 3162.3 5272.8 4726.2 True False 978.706594637587 398.2593736161919 2384.438718488128 5419.12485743636 8000.145449538178 4603.299774068852 1774.7627103620987 3171.5017694530547 6327.507334341513 4589.7423258576855 0.2132378083893187 0.08677161926334702 0.5195147241828107 1.180703506361588 1.743048929885882 1.0029538582448922 0.38668025007927836 0.6909977825084975 1.3786192960536388 1.0 12.164197445786526 -5.564211830738129 3.7709029704569472 1.0381718515998077 0.16879901226210206 0.5326149470106458 0.34594168634873457 0.19216323399076604 5.758878597237548 0.10780907635831297 0.2081242338821578 2.727647025814626e-06 5.564211830738129 -0.8693728393377057 SS(ph)PGAVAGLSNAPGTPR ddPTM_A459_Selumetinib_30min_R1 1 SSPGAVAGLSNAPGTPR 17 0 Q9BWG4-2;Q9BWG4;V9GYB2;U3KPY3 Q9BWG4-2;U3KPY3 SSBP4 Single-stranded DNA-binding protein 4 1 S(0.09)S(0.91)PGAVAGLSNAPGTPR 250.38 1.5121e-30 28815000.0 1179.9 1320.6 1516.2 1166.7 1357.4 1535.0 1307.2 1338.0 680.11 1130.3 True False 1207.389374314258 1165.9835380697157 1310.308367890444 962.9577466714028 1234.623409668434 1519.5592936684877 1208.5968515672425 1302.5118935634814 1154.09699673094 1275.385015054345 0.9466861850049338 0.9142208229724513 1.0273825961759562 0.7550329785161938 0.9680397645379469 1.1914514250457444 0.947632940093579 1.0212695603201676 0.9049008598252686 1.0 10.31671712034207 -6.52093805278232 24.999317606075696 1.0180087726671871 0.91216523932212 0.2091210357999833 0.09344782922706467 119.05737520427675 1533681.4134716247 0.030375002913236845 0.030833210741014347 3.0134358262214527e-07 6.52093805278232 -0.10584353334506713 SS(ph)PGAVAGLSNAPGTPR ddPTM_A459_Selumetinib_30min_R2 1 SSPGAVAGLSNAPGTPR 17 0 Q9BWG4-2;Q9BWG4;V9GYB2;U3KPY3 Q9BWG4-2;U3KPY3 SSBP4 Single-stranded DNA-binding protein 4 1 S(0.23)S(0.77)PGAVAGLSNAPGTPR 170.48 8.5431e-07 14746000.0 23234.0 24724.0 23554.0 24022.0 21970.0 21171.0 20908.0 20270.0 11507.0 18114.0 True False 21942.74729307122 26620.251299810003 22038.561283656163 20750.162159738622 19209.932185708003 24087.11307879675 21880.263428416045 20328.98234412086 13808.721532443446 17591.00175417589 1.2473847481632068 1.5132879680084552 1.2528315096338658 1.1795895679910773 1.0920317361203036 1.3692860369977942 1.2438327125527082 1.1556466555007312 0.784987786677096 1.0 14.102550021803914 -8.072101811157362 3.7675816550689545 0.8965601348087717 1.2707671355447667 0.6214857164589978 0.11631768224263105 0.16107764634640812 4.273909812414768 0.09041673205861646 0.03194572599731765 8.470288228681363e-09 8.072101811157362 0.374207000735995 SS(ph)PGEIVEER ddPTM_A459_Selumetinib_30min_R2 2 SSPGEIVEER 10 0 H0YA93;Q86UW6-2;Q86UW6 H0YA93 N4BP2 NEDD4-binding protein 2 1 S(0.109)S(0.891)PGEIVEER;S(0.022)S(0.978)PGEIVEER 174.77 7.363899999999999e-05 10169800.0 38684.0 34871.0 36449.0 32544.0 42918.0 36292.0 35767.0 41989.0 35365.0 33840.0 True False 36534.09814432154 37545.49357206258 34103.91102267058 28111.451058468643 37526.2571482119 41290.89357402539 37430.23637096596 42111.18103834683 42438.98818066068 32862.951273120896 1.1117108089498746 1.1424869683804573 1.0377616647767325 0.8554146833872898 1.1419016154798365 1.2564572557972853 1.1389797605177572 1.2814181139230245 1.2913930896818804 1.0 15.004174427576444 -6.514689754565314 24.531256831943203 1.2068612137897585 1.0387304543213631 0.32496624222408144 0.10595317222988673 345.3649456142446 1034593.1249895998 0.03454725474391932 0.03616764764985805 3.057104226237466e-07 6.514689754565314 -0.1681307594683954 SS(ph)PGGQDEGGFMAQGK ddPTM_A459_Selumetinib_30min_R1 4 SSPGGQDEGGFMAQGK 16 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30 A0A1B0GTU4 PXN Paxillin 1 S(0.406)S(0.594)PGGQDEGGFMAQGK;S(0.173)S(0.827)PGGQDEGGFMAQGK;S(0.123)S(0.877)PGGQDEGGFMAQGK;S(0.136)S(0.864)PGGQDEGGFMAQGK 314.61 2.119499999999999e-102 205904000.0 14628.2 16703.6 14833.5 13989.1 15086.900000000001 13641.199999999999 15871.8 14465.1 8403.8 13224.199999999999 True False 14969.0085984777 14747.934746707035 12819.192174583104 11546.166292929558 13722.292558808529 13503.981913218615 14674.577347540504 14081.438558733269 14260.63481073279 14921.65488461618 1.0031734894170712 0.9883578504359964 0.8590998970093687 0.7737859092849909 0.9196227003585131 0.9049922423243317 0.9834416799620258 0.9436914784331897 0.9557006190670658 1.0 13.865119925962421 -7.249355657208637 22.010830808159117 0.9660160640724802 0.9039982811248682 0.19384922693678763 0.06183191179906061 294.6234880904916 536665.811861732 0.026547319843996515 0.02034313772263057 5.631762644338976e-08 7.249355657208637 -0.062017782947611955 SS(ph)PGGQDEGGFMAQGK ddPTM_A459_Selumetinib_30min_R2 1 SSPGGQDEGGFMAQGK 16 0 A0A1B0GTU4;F5GZ78;P49023;A0A1B0GV30 A0A1B0GTU4 PXN Paxillin 1 S(0.316)S(0.684)PGGQDEGGFMAQGK 132.65 0.0022823 14762000.0 76887.0 77939.0 80934.0 97349.0 96054.0 69277.0 73702.0 67420.0 64414.0 71006.0 True False 72613.9283430475 83916.67068661586 75726.79455427654 84089.89826360809 83986.83778634472 78819.27791600779 77129.28903774242 67616.1810380182 77298.59987753631 68955.87228425608 1.0530492318871967 1.216961919366157 1.098192105265651 1.2194740705616074 1.2179794846206375 1.143039385987199 1.118531119725281 0.9805717598536744 1.1209864702876804 1.0 16.073385796475513 -7.557389826364525 4.51354811418045 1.0380109200182024 1.1617450941466367 0.44865513304093385 0.06128940144338487 0.1801969019967983 8.554179873915068 0.02859602697766388 0.016409274643172034 2.7708318661960038e-08 7.557389826364525 0.12373417412843435 SS(ph)PIMR ddPTM_A459_Selumetinib_30min_R2 4 SSPIMR 6 0 A0A087WZV0;O43314;O43314-2;A0A087WWN8;K7ENU7;H0Y9S9 A0A087WZV0;K7ENU7 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 S(0.017)S(0.983)PIMR;S(0.019)S(0.981)PIMR;S(0.019)S(0.981)PIMR;S(0.019)S(0.981)PIMR 111.65 0.025184 216053000.0 584408.0 489977.0 487582.0 578733.0 609383.0 466672.0 535162.0 544046.0 384379.0 571037.0 True False 551928.9429305834 527556.6603756282 456211.5049591415 499908.5670298888 532826.8595868585 530951.8319733711 560048.0934033854 545629.0837883359 461265.54044660565 554549.6780776934 0.995274120154222 0.9513244371619967 0.8226702187269603 0.9014675993732173 0.9608280027027777 0.9574468311186789 1.009915099662039 0.9839138049447975 0.8317839838002421 1.0 19.08095718118272 -6.270011620081819 22.812692647576366 0.9591469526016634 0.9133002696991618 0.08896559837918683 0.0613238812264806 461.42663485695283 1227958.0796031945 0.019621140769190897 0.022656547420331793 5.370174276177361e-07 6.270011620081819 -0.0458466829025016 SS(ph)PLSFPSVPQEETLR ddPTM_A459_Selumetinib_30min_R1 1 SSPLSFPSVPQEETLR 16 0 Q9ULD5 Q9ULD5 ZNF777 Zinc finger protein 777 1 S(0.339)S(0.661)PLSFPSVPQEETLR 287.42 1.8234e-74 7803400.0 763.82 1056.7 675.3 744.04 628.46 747.77 745.95 1049.1 335.92 690.86 True False 781.615519865003 932.9810727534973 583.5979691573788 614.107381360581 571.6159039636249 740.2481127208365 689.6823909322093 1021.2744600429361 570.0317053739209 779.5386105462666 1.002664280243003 1.1968375397078856 0.7486453669670304 0.7877831489709554 0.7332746527629483 0.9495977527041323 0.8847315342711634 1.3101011883520068 0.7312424268176628 1.0 9.606476671150782 -10.230742804000016 11.845582836733609 0.9999947795067683 0.9307530837719958 0.012953541558920811 0.18834970205418058 0.0 0.0 0.18602970372238148 0.04511883046763164 5.878373759758566e-11 10.230742804000016 -0.06924169573477246 SS(ph)PNVANQPPS(ph)PGGK ddPTM_A459_Selumetinib_30min_R1 3 SSPNVANQPPSPGGK 15 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 2 S(0.403)S(0.597)PNVANQPPS(1)PGGK;S(0.173)S(0.827)PNVANQPPS(1)PGGK;S(0.426)S(0.574)PNVANQPPS(1)PGGK 169.6 9.2315e-05 3905000.0 3373.5999999999995 4142.2 3239.58 3358.7200000000003 3598.6299999999997 2949.88 3806.64 3909.7 2104.31 3476.5199999999995 True False 3452.1983161171133 3657.2292983434645 2799.6628297391667 2772.1826029829194 3273.134551889729 2920.2068854767426 3519.5020800565526 3806.0020555045908 3570.860377278508 3922.7652061724602 0.8800420455155177 0.9323089978948585 0.7136962531771988 0.7066909328707458 0.83439471389709 0.7444256110158735 0.8971992701777373 0.9702344788609466 0.910291641125951 1.0 11.93765527135729 -7.475938560146279 4.546513471104278 0.9528328681179201 0.801350290117899 0.513005160726927 0.06985650608931926 0.19338713520903353 8.777893627855224 0.034131982700551976 0.021515129837346648 3.342423221070455e-08 7.475938560146279 -0.15148257800002107 SS(ph)PNVANQPPS(ph)PGGK ddPTM_A459_Selumetinib_30min_R2 1 SSPNVANQPPSPGGK 15 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 2 S(0.401)S(0.599)PNVANQPPS(1)PGGK 188.34 0.00045202 14335000.0 44826.0 36138.0 43621.0 44703.0 47753.0 33879.0 43373.0 44834.0 35492.0 40871.0 True False 42334.75037269565 38909.66839801546 40814.472350953765 38614.37428302374 41753.841222763505 38545.52472705847 45389.93044196905 44964.459517331736 42591.391729337185 39690.948034389 1.0666097049638623 0.9803159240314284 1.028306814833229 0.9728760887638033 1.0519738955740532 0.9711414475074238 1.143583932604541 1.132864336683862 1.0730756970691449 1.0 15.276522401654823 -7.25942818284244 24.97666958190439 1.0984530195873858 1.0112338341143896 0.3684599786788806 0.04755029717338541 159.82043284724162 1984793.3352071755 0.01772186018384059 0.013005700885531254 5.5026490760796996e-08 7.25942818284244 -0.08721918547299623 SS(ph)PPFWALPPSAPSER ddPTM_A459_Selumetinib_30min_R2 1 SSPPFWALPPSAPSER 16 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 S(0.221)S(0.779)PPFWALPPSAPSER 109.55 0.0029501 1454500.0 3479.8 3220.6 4186.4 3871.9 3162.5 2710.2 3398.4 2892.0 2033.2 2274.9 True False 3286.4066467431026 3467.6096641388194 3917.051581807681 3344.54054059995 2765.198476891286 3083.5054492539293 3556.4323338018476 2900.4152412036256 2439.896812354568 2209.2177260999633 1.4875883929035605 1.5696097415714452 1.773049136593086 1.5139026367058106 1.2516640819159197 1.395745386624879 1.6098152263517214 1.312869803160536 1.104416637404876 1.0 11.10931989298214 -8.184795884317671 0.4515325404182472 0.9628853145009701 1.5890794231424448 0.6357161341256727 0.1362426213298968 0.7090845759602429 0.3897560020248841 0.17701089650258647 0.10855230734671197 6.534375920580217e-09 8.184795884317671 0.6261941086414746 SS(ph)PPPGYVPER ddPTM_A459_Selumetinib_30min_R1 1 SSPPPGYVPER 11 0 J3KRN4;J3QRB6;Q99759;Q99759-2 J3KRN4 MAP3K3 Mitogen-activated protein kinase kinase kinase 3 1 S(0.375)S(0.625)PPPGYVPER 143.0 0.00087569 12470000.0 1757.4 2234.1 1891.1 1796.4 2163.9 1868.4 2261.9 1956.8 919.3 1934.7 True False 1798.3440006948708 1972.5305333950869 1634.2990070687367 1482.6924626043608 1968.1756270675746 1849.6055923714662 2091.283061933864 1904.899307417802 1559.9849569845371 2183.0375905738683 0.8237805929040962 0.903571492269428 0.74863530253692 0.679187783575727 0.9015766084679231 0.8472623652280991 0.95796933179887 0.8725911618026924 0.7145937219406535 1.0 11.092121257532057 SS(ph)PQHSLSNPLPR ddPTM_A459_Selumetinib_30min_R1 1 SSPQHSLSNPLPR 13 0 Q86UE8-2;Q86UE8 Q86UE8-2 TLK2 Serine/threonine-protein kinase tousled-like 2 1 S(0.364)S(0.589)PQHS(0.043)LS(0.004)NPLPR 147.7 0.00056637 8987600.0 838.21 793.15 884.93 1031.0 940.05 819.61 824.87 678.64 532.73 524.99 True False 857.7386621272606 700.2876292745688 764.7613665725441 850.955204266921 855.0226434793074 811.3654675463382 762.649391793353 660.6402626666079 904.0039009402512 592.377580335646 1.4479593600440765 1.1821643028383688 1.2910032249012935 1.4365081200148775 1.4433744150054506 1.3696761904571269 1.2874379738700263 1.115235087547175 1.5260602881493848 1.0 9.210373229877096 -11.16969197039299 3.015874953652511 0.9710874819585187 1.3359898884228019 0.41721682921086856 0.12174157893468725 183961127.82797307 174647045.3955225 41046688.61511662 0.030355356825491987 6.765626670592305e-12 11.16969197039299 0.3649024064642832 SS(ph)PQLDPLR ddPTM_A459_Selumetinib_30min_R1 1 SSPQLDPLR 9 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.438)S(0.562)PQLDPLR 89.266 0.030097 2853800.0 1369.1 2387.8 1363.7 1662.1 2380.0 1378.9 2071.0 1889.1 748.9 1555.5 True False 1400.9973661951456 2108.2352659418957 1178.517030267906 1371.845436481134 2164.7294202231287 1365.029517941027 1914.7828026283346 1838.9949313383959 1270.8286025081263 1755.1635768530787 0.7982146990009127 1.2011617001088053 0.6714570914130571 0.7816054609227846 1.2333491013438083 0.7777221086073683 1.0909426493805467 1.0477627017737132 0.724051375762172 1.0 10.77738977702525 SS(ph)PQLDPLR ddPTM_A459_Selumetinib_30min_R2 1 SSPQLDPLR 9 0 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.207)S(0.793)PQLDPLR 124.6 0.0052584 34137000.0 39160.0 33130.0 42213.0 49141.0 53803.0 41163.0 40241.0 47526.0 44660.0 39718.0 True False 36983.643969900506 35670.96447025989 39497.061538039285 42447.91102704672 47043.78613507724 46832.829609489854 42112.28623602879 47664.29279164714 53593.24790466016 38571.238140242785 0.9588399479277829 0.9248073484331079 1.024002947336828 1.1005068303150802 1.219659736201072 1.214190465942742 1.0918054038843907 1.2357470252404792 1.3894614352227486 1.0 15.235237836901096 -5.794311929455668 1.7009618195922735 1.2004849883283264 0.9405776484171583 0.5249246603079298 0.09588007293679471 0.28015054604972955 1.651520424410652 0.0303222310817112 0.06223260570348402 1.6057874913061291e-06 5.794311929455668 -0.2599073399111681 SS(ph)PQLDPLRK ddPTM_A459_Selumetinib_30min_R1 2 SSPQLDPLRK 10 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.048)S(0.952)PQLDPLRK;S(0.073)S(0.927)PQLDPLRK 95.183 0.011827 439390000.0 13015.9 17960.199999999997 9960.0 9360.5 13352.5 11979.099999999999 15967.9 16462.1 8011.0 15285.2 True False 13319.145145467379 15857.411434529546 8607.486706363823 7725.864393346761 12144.768732575338 11858.601130152558 14763.42844716995 16025.471631563061 13594.081899709709 17247.20431045624 0.7722495139338352 0.9194192374074144 0.4990656196462793 0.4479487953107218 0.7041586864725946 0.6875665711783328 0.8559896538257807 0.9291634367575449 0.7881904600311483 1.0 14.074074906407528 -7.277175570952002 2.8721011022663463 0.8955771930703395 0.662641426872377 0.4041105536319728 0.13272311908522616 0.32010157527458605 5.307433012456333 0.06633884585375421 0.044465726729928184 5.2823166194511795e-08 7.277175570952002 -0.2329357661979624 SS(ph)PQLDPLRK ddPTM_A459_Selumetinib_30min_R2 2 SSPQLDPLRK 10 1 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 1 S(0.228)S(0.772)PQLDPLRK;S(0.043)S(0.957)PQLDPLRK 107.34 0.011254 1674470000.0 587860.0 458510.0 583350.0 565190.0 598390.0 510640.0 666080.0 647740.0 548330.0 497960.0 True False 555189.0945900333 493676.2426579805 545817.8961034555 488210.1469928677 523214.89852552646 580976.0248716056 697054.0398124813 649624.8161608704 658011.3216202934 483582.6009445425 1.1480750000219768 1.0208726320875128 1.1286963075953391 1.0095692980667348 1.081955590427723 1.201399768595546 1.441437385156088 1.3433585387315654 1.3607009853850274 1.0 18.883402812525524 -6.94195845993597 3.7320212283543635 1.3164719582028135 1.0744352893694031 0.4078468511699681 0.11613549472313751 0.18780823379830197 5.362845639810428 0.04093711736622583 0.03495333543351604 1.1429876557960216e-07 6.94195845993597 -0.24203666883341035 SS(ph)PRPGQPPK ddPTM_A459_Selumetinib_30min_R2 1 SSPRPGQPPK 10 1 P57739 P57739 CLDN2 Claudin-2 1 S(0.163)S(0.837)PRPGQPPK 122.69 0.020821 5383700.0 30794.0 10602.0 19606.0 23661.0 13728.0 11960.0 30387.0 25618.0 14518.0 9668.4 True False 29082.592758149043 11415.13930919696 18344.57130539877 20438.33098249836 12003.36591012286 13607.38143792966 31800.055710698194 25692.54413871179 17422.00566681271 9389.248170479968 3.097435729687649 1.2157671308642628 1.95378490080543 2.176780356786924 1.2784160874415635 1.4492514406756878 3.38685857837674 2.736379278959714 1.8555272318382139 1.0 13.196793925592761 -7.156472052333 22.515375316999084 2.3938029657892894 1.8245077097582496 0.04125966683507887 0.7685588044694207 33.3920324678444 7139.674050382246 0.2847396521996949 0.2205584708453302 6.974738791939538e-08 7.156472052333 -0.5692952560310398 SS(ph)PSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R1 1 SSPSARPPDVPGQQPQAAK 19 1 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 S(0.414)S(0.571)PS(0.015)ARPPDVPGQQPQAAK 147.1 0.00020335 10177000.0 2480.6 3128.6 2232.2 2612.5 2305.1 2592.0 2794.0 2165.9 1296.6 2098.5 True False 2538.3931535926363 2762.3020575533196 1929.079500596919 2156.27591769867 2096.6041119984598 2565.926833347699 2583.246330537696 2108.453296165281 2200.235500082835 2367.862916120982 1.0720186275610144 1.1665802267297236 0.8146922220299496 0.9106422094869697 0.8854415083425113 1.0836466992570601 1.0909610995426855 0.8904456764833902 0.9292072970538544 1.0 11.209369845376779 -5.2402099952537 24.996579607585304 0.9527231110176865 1.1192994471828306 0.3847331895044198 0.08528681857667286 908.1437462900611 1069292.019030622 0.023291530444907553 0.0614945947552542 5.751617610064506e-06 5.2402099952537 0.1665763361651441 SS(ph)PSARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R2 1 SSPSARPPDVPGQQPQAAK 19 1 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 S(0.389)S(0.611)PSARPPDVPGQQPQAAK 214.34 2.0354e-16 3859200.0 19648.0 14733.0 16528.0 18193.0 19960.0 13058.0 18445.0 21498.0 16563.0 14485.0 True False 18556.042817175818 15862.97372593841 15464.606474325765 15715.082015324495 17452.446355335993 14856.620971278067 19302.72904807412 21560.555620814506 19876.062808886818 14066.780413450242 1.319139296397424 1.1276904351738297 1.0993707173774436 1.1171768914724933 1.2406852060225861 1.056149348650712 1.3722208267086773 1.5327285268631148 1.4129788213571537 1.0 13.780004543726898 -7.280459660072989 23.65797574477083 1.3738761566088937 1.157525414110094 0.22037325993830592 0.14688806144634992 477.68259967342937 594151.5141325563 0.058588142833886137 0.03959197387289362 5.242522945056538e-08 7.280459660072989 -0.21635074249879982 SS(ph)PSIICMPK ddPTM_A459_Selumetinib_30min_R1 1 SSPSIICMPK 10 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 S(0.026)S(0.972)PS(0.002)IICMPK 128.51 0.0031049 28952000.0 3170.4 4351.1 2822.8 2858.5 3382.5 3198.6 3861.3 3177.7 1621.8 3355.2 True False 3244.264151475484 3841.671189228489 2439.4792645305006 2359.316635690585 3076.5534722288794 3166.424988096433 3570.039032249534 3093.4170733756923 2752.0761484145783 3785.87260241559 0.8569395994480822 1.014738632984453 0.6443638021453711 0.623189653604618 0.8126405178731776 0.8363791708353007 0.9429897429648472 0.8170948677464546 0.7269331109183669 1.0 11.886410148700099 -6.744553877957752 3.8984885823599917 0.8593965421981697 0.7840472690662945 0.08571405066130722 0.1227577799921476 0.6964707658238694 23.149009899601904 0.046810390396643496 0.0442558528807385 1.800719725847915e-07 6.744553877957752 -0.07534927313187523 SS(ph)PSIICMPK ddPTM_A459_Selumetinib_30min_R2 1 SSPSIICMPK 10 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 S(0.205)S(0.795)PSIICMPK 215.83 0.00013758 16304000.0 300200.0 231850.0 271980.0 321500.0 348000.0 280530.0 285160.0 293830.0 262100.0 257640.0 True False 283516.08579581545 249632.14948474942 254481.1029094331 277711.14538156585 304281.12884052726 319170.46110220836 298420.50503382046 294684.99665382516 314527.32368588087 250201.26377088844 1.133152093330087 0.9977253740546244 1.0171055856155218 1.1099510098233094 1.2161454512842118 1.2756548719692944 1.192721813376158 1.177791799339874 1.2570972622020662 1.0 17.932729551036424 -6.054398014936191 3.609063709508503 1.1995995743098786 1.0452041840100266 0.3797949481538896 0.07794709836672363 0.21107530920180678 5.520065977695039 0.02239312841894676 0.03113566354430627 8.822709608734947e-07 6.054398014936191 -0.15439539029985205 SS(ph)PSKCPSLDDR ddPTM_A459_Selumetinib_30min_R1 2 SSPSKCPSLDDR 12 1 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 S(0.182)S(0.818)PSKCPSLDDR;S(0.223)S(0.754)PS(0.023)KCPSLDDR 202.29 0.00031246 11926000.0 2940.0 3260.2 3456.3 3907.1 4762.1 2883.8 3559.9 3146.7 1918.38 2376.8 True False 3008.496279755844 2878.4942683741406 2986.953444096914 3224.7983303504207 4331.3688958170405 2854.7915902809004 3291.373876908068 3063.2392940778823 3255.350747068419 2681.88543199254 1.1217840418785692 1.0733099311537435 1.1137513215386388 1.202437021313963 1.6150462074731493 1.0644718660334038 1.2272611788873848 1.1421961794251632 1.2138291622136208 1.0 11.38903189243892 -5.774366902284908 5.112530662010332 1.2276760831859321 1.0984640377081616 0.08417763117486987 0.15413601247503333 0.39306151317238464 28.3977290549169 0.04365907976666056 0.07024676187717098 1.6812530984067721e-06 5.774366902284908 -0.12921204547777054 SS(ph)PSPALEQPFR ddPTM_A459_Selumetinib_30min_R2 1 SSPSPALEQPFR 12 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.181)S(0.787)PS(0.032)PALEQPFR 97.463 0.016179 16520000.0 9318.4 9408.1 8580.9 12159.0 13780.0 6844.8 9407.4 8402.9 8705.9 7445.2 True False 8800.520632510756 10129.671018190527 8028.814236177513 10502.923224555076 12048.83320523696 7787.609069092054 9844.862740409462 8427.351047825021 10447.323263170189 7230.237731047277 1.2171827483238271 1.4010149313200075 1.1104495501857536 1.452638711927078 1.6664504893799288 1.077088936599052 1.3616236570112703 1.1655703949591083 1.4449487903154918 1.0 12.819827368597043 SS(ph)PSVKPAVDPAAAK ddPTM_A459_Selumetinib_30min_R1 1 SSPSVKPAVDPAAAK 15 1 H3BV90;Q6FI81-3;Q6FI81;H3BPG7;H3BT65 H3BV90 CIAPIN1 Anamorsin 1 S(0.178)S(0.806)PS(0.017)VKPAVDPAAAK 128.64 0.0045214 7724400.0 1449.0 2041.0 1636.5 1725.0 1518.8 1338.0 1524.4 1385.9 1048.6 1594.8 True False 1482.7588807368093 1802.0387711648416 1414.272288651043 1423.7611322603661 1381.4248081659196 1324.5409348067988 1409.4132806985192 1349.1414299623539 1779.3976132861799 1799.508114667496 0.823980102479719 1.0014063045766333 0.7859215955313239 0.7911946162707032 0.767668007110472 0.7360572169753958 0.7832214087897811 0.7497278945094623 0.9888244452929116 1.0 10.813386892600837 -8.27388809278523 23.84421307189168 0.9944123441041637 0.8061000213374436 0.5384916287018651 0.07017142839724555 391.44158412869245 749751.4024049015 0.07164436185619569 0.01909185239650334 5.322453883998425e-09 8.27388809278523 -0.18831232276672005 SS(ph)PSVLIHSLGK ddPTM_A459_Selumetinib_30min_R2 1 SSPSVLIHSLGK 12 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 S(0.061)S(0.938)PS(0.001)VLIHSLGK 138.2 0.0012603 15513000.0 45021.0 35145.0 65092.0 73967.0 80986.0 69822.0 48897.0 47458.0 58135.0 68856.0 True False 42518.91305334249 37840.5084910137 60904.051586811045 63892.566999808 70811.81465597391 79439.34671899043 51170.807387567365 47596.09492290514 69763.62442761792 66867.94837062691 0.6358638793233826 0.5658990504879301 0.91081083046305 0.9555036240333357 1.0589799205964485 1.1880033507037546 0.7652516434921035 0.7117923621507831 1.0433043951182894 1.0 16.029027233058954 -5.308299862445397 5.033554958727473 0.9516200876165573 0.5994673140297959 0.5355818598764899 0.13183041873178536 0.1555666743598293 9.304622094162404 0.037987761523187294 0.08509101821502447 4.916999199145451e-06 5.308299862445397 -0.35215277358676134 SS(ph)PTPESR ddPTM_A459_Selumetinib_30min_R2 2 SSPTPESR 8 0 K7EQ92;Q8NCA9 K7EQ92 ZNF784 Zinc finger protein 784 1 S(0.121)S(0.879)PTPESR;S(0.223)S(0.777)PT(0.001)PESR 101.46 0.015068000000000003 1889600.0 14849.2 14172.7 23170.0 17138.6 17524.0 19579.5 30716.0 78524.0 21885.0 39089.0 True False 14023.94091005738 15259.700517586854 21679.26742558858 14804.293114265944 15322.478453452299 22276.3983999953 32144.35486259933 78752.49183965192 26262.611517991194 37960.39900458108 0.36943607753872565 0.40198999266960567 0.5711022010851972 0.3899930849641321 0.4036437670637544 0.5868325672052861 0.8467865382215854 2.074595997532798 0.6918423464100525 1.0 15.21220753626319 -7.527085616270888 24.998863277619446 1.3220698743360815 0.4737224987521964 0.5346476776468667 0.3342799507098522 84.24887129410503 500626.55566520867 0.14669238786120056 0.08513981648572204 2.9710802589550453e-08 7.527085616270888 -0.8483473755838851 SS(ph)PTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R1 1 SSPTQETQAPFIAK 14 0 O15231-5 O15231-5 ZNF185 Zinc finger protein 185 1 S(0.214)S(0.784)PT(0.002)QETQAPFIAK 98.582 0.010293 8224300.0 2386.3 3238.7 2642.9 2746.1 2663.6 2442.6 3149.8 2797.2 1735.7 2042.8 True False 2441.896147068492 2859.511498369217 2284.0086964105376 2266.5451856812697 2422.677850296774 2418.029661703352 2912.2080500814714 2723.0091694138778 2945.3561294877213 2305.0132785570363 1.059384850310774 1.240561833187921 0.9908874355120211 0.9833111187542277 1.0510472424754955 1.0490306863729066 1.263423546047659 1.1813420750090045 1.2778044087154008 1.0 11.170559346315923 -7.2460316791488015 24.150630406052787 1.195754347354196 1.0631125864675677 0.2593221705208256 0.09657617169244026 650.7878784754254 1020071.701932773 0.036870016781335585 0.028432616544850887 5.6750320798115674e-08 7.2460316791488015 -0.13264176088662838 SS(ph)PTSASACGAQGLR ddPTM_A459_Selumetinib_30min_R2 1 SSPTSASACGAQGLR 15 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;A0A2R8YFX5;H0YHA8 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.156)S(0.843)PTS(0.001)ASACGAQGLR 136.33 0.00040612 9004600.0 22187.0 15234.0 20875.0 21066.0 25021.0 20717.0 25894.0 20525.0 17146.0 21294.0 True False 20953.935361598134 16402.398814969496 19531.925226981497 18196.774459123048 21877.638289421935 23570.578699798396 27098.122307987593 20584.72435190332 20575.679099267858 20679.18689154364 1.0132862317795894 0.7931839342134359 0.9445209489822207 0.8799559941384482 1.057954473943479 1.1398213490413946 1.3104056000900526 0.9954319993268717 0.9949945908019184 1.0 14.335891839351234 -6.357624959623742 4.097968846105177 1.1013420759944685 0.9020383578593335 0.41063599473000634 0.10244292717097728 0.22472646340860325 6.719944405794781 0.0337845440009635 0.038810364602387626 4.389095599499191e-07 6.357624959623742 -0.19930371813513503 SS(ph)PVCSTAPVETEPK ddPTM_A459_Selumetinib_30min_R2 1 SSPVCSTAPVETEPK 15 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 S(0.227)S(0.773)PVCSTAPVETEPK 263.72 9.9685e-37 5522300.0 25839.0 19777.0 19338.0 25978.0 23977.0 18849.0 28398.0 26492.0 23742.0 18113.0 True False 24402.97182171244 21293.832306922115 18093.81413362243 22439.75158545042 20964.794902900332 21445.27865581408 29718.563269569462 26569.087334013297 28491.06340690644 17590.030626774205 1.3873183247656258 1.210562548680857 1.0286402859402304 1.2757084999780692 1.1918566458314925 1.2191723318077519 1.6895117410616742 1.5104628239573303 1.619727902209534 1.0 14.102470374301154 -7.1917057160421765 10.919206570239997 1.4973696212926246 1.2109875990127055 0.2550852241284761 0.19193684167104538 0.8445064668748445 130.20533958812783 0.06936127008599537 0.05371677803178919 6.431233590000719e-08 7.1917057160421765 -0.28638202227991916 SS(ph)PVESLK ddPTM_A459_Selumetinib_30min_R1 1 SSPVESLK 8 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B1AKL5 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.185)S(0.815)PVESLK 89.08 0.03017 7646300.0 5652.1 6824.6 4769.9 4261.2 5025.3 4518.6 6213.9 5881.4 2755.5 5649.9 True False 5783.782932927895 6025.572659329532 4122.173779185219 3517.0614126306505 4570.762502288779 4473.146986560538 5745.180520160409 5725.406166520376 4675.882246242678 6375.119699686409 0.9072430331327579 0.9451701212176343 0.6466033538771025 0.551685549183281 0.7169688911901707 0.7016569409325084 0.901187866393005 0.8980860652392155 0.7334579531852059 1.0 12.638236715029308 -8.890757320270994 0.5849352749914596 0.9988985751792318 0.7530655435388396 0.2198572095021466 0.12447933565599373 2.4399248690054467 1.6195766018088928 0.17103445761522187 0.061883930342673185 1.2860050669108141e-09 8.890757320270994 -0.24583303164039216 SS(ph)PVGGGPR ddPTM_A459_Selumetinib_30min_R1 1 SSPVGGGPR 9 0 Q00587-2;Q00587 Q00587-2 CDC42EP1 Cdc42 effector protein 1 1 S(0.225)S(0.775)PVGGGPR 99.788 0.018495 5698500.0 1851.4 2055.1 1706.4 1743.0 2754.4 1468.3 2488.6 1947.7 1100.4 1449.7 True False 1894.53401780271 1814.4879366099292 1474.6802525842593 1438.617770162214 2505.265006328816 1453.530235109733 2300.882898416646 1896.0406689787692 1867.298429963869 1635.7831162738084 1.1581816678230037 1.1092472581225785 0.9015133106053024 0.8794673058120795 1.531538613771502 0.888583712992934 1.40659411111779 1.1591027258539066 1.1415317907287337 1.0 10.675765762881623 SS(ph)PVLQHK ddPTM_A459_Selumetinib_30min_R1 1 SSPVLQHK 8 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.227)S(0.773)PVLQHK 164.66 0.00019443 22944000.0 8282.5 10682.0 9985.0 8085.6 8161.8 8564.6 6787.3 9056.2 9763.9 7849.8 True False 8475.466135060464 9431.346474072925 8629.091843678996 6673.601745509811 7423.566631082822 8478.447900034616 6275.328496513418 8816.000157316592 16568.62517295912 8857.398293527034 0.9568798708368251 1.0647987322603898 0.9742242087030359 0.7534494356414867 0.8381204485867986 0.9572165120124095 0.7084843978507113 0.995326151671344 1.8705972819430998 1.0 13.112667279127425 -8.028680142031172 22.310007639199785 1.434520828445847 0.89468358085138 0.48794385772274385 0.21905073688754365 143.93689135200427 111964.61487385306 0.13622575857834504 0.05183463667379125 9.360948543646568e-09 8.028680142031172 -0.539837247594467 SS(ph)PVLQHK ddPTM_A459_Selumetinib_30min_R2 3 SSPVLQHK 8 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.164)S(0.836)PVLQHK;S(0.226)S(0.774)PVLQHK;S(0.197)S(0.803)PVLQHK 110.53 0.007926899999999999 145673600.0 176301.0 130896.0 119146.0 132016.0 131948.0 117570.0 216984.0 360770.0 171401.0 270020.0 True False 166502.89620882086 140935.30230302285 111480.27607635634 114035.1930596975 115371.5126099134 133764.200305802 227074.18594563915 361819.7809713118 205685.9893440804 262223.8210037854 0.6349648005717118 0.5374618589704264 0.4251340539910256 0.4348773220646926 0.4399734248714495 0.5101146028372113 0.8659555988331097 1.379812785834162 0.7843909396054112 1.0 18.00043922362356 -7.378040893954343 3.5267656759820194 1.0702605643732228 0.48894429496688474 0.7434400326907039 0.14913927783723582 0.11325335249420976 2.5812064129109986 0.06470501282241604 0.0414893230228492 4.187541326144985e-08 7.378040893954343 -0.5813162694063381 SS(ph)PVNNHHS(ph)PGQTPTLGQPEAR ddPTM_A459_Selumetinib_30min_R2 1 SSPVNNHHSPGQTPTLGQPEAR 22 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;E7EWM2;E7EMW0;Q96L14 H0Y2V6 CEP170;CEP170P1 Centrosomal protein of 170 kDa;Cep170-like protein 2 S(0.345)S(0.734)PVNNHHS(0.917)PGQT(0.003)PTLGQPEAR 73.51899999999998 0.012027 0.0 9481.9 8178.4 11423.0 10025.0 9701.1 9274.5 11293.0 9671.9 8059.1 10907.0 True False 8954.933957053108 8805.656982299233 10688.056616422022 8659.577705910402 8482.361089065631 10551.978189471458 11818.146876654979 9700.043627730764 9671.145190068217 10592.086570210684 0.8454362507041885 0.8313429959177612 1.0090605420919845 0.8175516361681471 0.8008205968521376 0.9962133635829575 1.1157524816585698 0.9157821325791735 0.9130538280594747 1.0 13.370699198150048 -6.779249829018606 24.739018211775957 0.9908713019214851 0.8650328505752624 0.41890598803960843 0.0748610864187052 234.93798718958462 326330.58633361926 0.027808700562751944 0.024577723715291346 1.662456043133122e-07 6.779249829018606 -0.12583845134622273 SS(ph)PVPPVPERR ddPTM_A459_Selumetinib_30min_R1 1 SSPVPPVPERR 11 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 S(0.193)S(0.807)PVPPVPERR 110.8 0.0044217 48619000.0 1063.7 1345.7 1746.3 1738.8 1622.3 1403.3 1513.5 1381.4 512.43 958.32 True False 1088.482140400099 1188.1448184010426 1509.1620517392719 1435.1512213184485 1475.5632514403287 1389.1840760944547 1399.3354764741598 1344.7607845804127 869.5562835935888 1081.3297068272857 1.0066144798646097 1.0987812606084426 1.395653927022206 1.3272096496167718 1.3645821825886557 1.2846998166456003 1.2940877029818503 1.243617720007024 0.8041546237964198 1.0 10.078590765070349 -8.249103266399645 23.35392021102018 0.9020773504005923 1.2603585342545358 0.57329013410199 0.12054786177406296 200.89222618610182 380320.210969721 0.08841475805605231 0.03278571528319778 5.635036501813232e-09 8.249103266399645 0.3582811838539435 SS(ph)PVTVNQTDKEK ddPTM_A459_Selumetinib_30min_R1 2 SSPVTVNQTDKEK 13 1 Q8IVL0-3;Q8IVL0-2;Q8IVL0;A0A2R8YFX5;H0YHA8 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.22)S(0.78)PVTVNQTDKEK;S(0.032)S(0.942)PVT(0.025)VNQT(0.001)DKEK 240.37 3.9412e-17 13406400.0 4476.5 4959.7 5402.0 5207.8 4032.8 4775.3 4773.6 4716.3 2632.9300000000003 4017.3399999999997 True False 4580.79374024729 4379.016018298023 4668.438071061984 4298.355492513357 3668.033952048671 4727.264817625489 4413.5235087525925 4591.208403298542 4467.889908401284 4533.004721205364 1.0105424595783827 0.9660294413136207 1.0298771693801827 0.9482353884181236 0.8091837925713233 1.042854598300191 0.9736419395519622 1.0128399782645057 0.9856353970911449 1.0 12.146251948479415 SS(ph)PVVNDGVVR ddPTM_A459_Selumetinib_30min_R1 1 SSPVVNDGVVR 11 0 H0YAM1;H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0YAM1 GRSF1 G-rich sequence factor 1 1 S(0.237)S(0.763)PVVNDGVVR 92.906 0.024348 7434400.0 2113.2 2714.5 2492.2 2871.8 2326.2 2646.1 2208.4 2240.4 1194.0 1812.6 True False 2162.4334484285887 2396.6850780631858 2153.77292867469 2370.294040362505 2115.795620723966 2619.4826364665714 2041.8186100069595 2180.977314155176 2026.1307936903497 2045.2648662191514 1.0572877303789183 1.1718213702529712 1.0530533058322784 1.1589178885882874 1.0344849000585419 1.2807547226432883 0.9983150073767402 1.0663544610664049 0.9906446970048566 1.0 10.998071972052603 SS(ph)PVVNDGVVR ddPTM_A459_Selumetinib_30min_R2 2 SSPVVNDGVVR 11 0 H0YAM1;H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0YAM1 GRSF1 G-rich sequence factor 1 1 S(0.228)S(0.772)PVVNDGVVR;S(0.208)S(0.792)PVVNDGVVR 147.52 0.00066503 11754200.0 53993.0 29073.0 50516.0 52788.0 59209.0 39334.0 39937.0 42293.0 46956.0 39929.0 True False 50992.285211104165 31302.805615570964 47265.85555766214 45598.183335620786 51770.63608482406 44751.90146149879 41794.14963366419 42416.06562801692 56348.51206026022 38776.14602199897 1.3150426342570143 0.8072696445338292 1.2189415505823267 1.1759338669127009 1.3351155644878399 1.1541090606608915 1.0778314484877638 1.093870071666042 1.45317464062292 1.0 15.242881800032531 SS(ph)QPSPTAVPASDS(ph)PPTK ddPTM_A459_Selumetinib_30min_R2 1 SSQPSPTAVPASDSPPTK 18 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 S(0.37)S(0.508)QPS(0.121)PT(0.001)AVPAS(0.027)DS(0.906)PPT(0.067)K 163.6 8.3676e-05 20033000.0 47533.0 41234.0 43869.0 47361.0 46030.0 38692.0 46224.0 47078.0 39907.0 34255.0 True False 44891.306149675205 44396.51521179285 41046.51630095579 40910.350097717965 40247.29988657889 44021.471788994524 48373.50759111833 47214.98918581751 47889.5150947441 33265.9691448214 1.349466355669471 1.3345925687153526 1.2338890871407426 1.2297958288729605 1.2098640418790954 1.3233184819401982 1.4541439445376496 1.4193180117575979 1.439594766839949 1.0 15.021759444234801 -6.996395951191034 23.923683316194136 1.3668536157402786 1.27021416389625 0.010796328734308025 0.1293312583843526 141.09279889534167 936556.4711087559 0.04369992385121516 0.03833747914062012 1.0083331581326618e-07 6.996395951191034 -0.09663945184402856 SS(ph)RS(ph)KS(ph)RS(ph)PSPK ddPTM_A459_Selumetinib_30min_R2 1 SSRSKSRSPSPK 12 3 Q16629;C9JAB2 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 4 S(0.273)S(0.868)RS(0.881)KS(0.98)RS(0.986)PS(0.013)PK 61.344 0.045454 0.0 26994.0 24474.0 43669.0 37310.0 38742.0 27150.0 25784.0 30429.0 24542.0 32312.0 True False 25493.781545543778 26351.077103686723 40859.38408321222 32228.313636660056 33874.8836021256 30889.666056838687 26983.007090026727 30517.54335220787 29451.085760774055 31379.06860334167 0.8124454510682593 0.839766069439056 1.3021222713685312 1.027064061207602 1.0795375742452133 0.9844035349586231 0.8599046527197818 0.9725445881767806 0.9385583151960636 1.0 14.937514910272219 -7.0043635871366625 24.52973797708917 0.9378482429286444 1.0207849942150413 0.056913379598214076 0.13036777092826426 435.22825376926465 2446630.670680071 0.04954636172061414 0.04262030254114256 9.900027771129304e-08 7.0043635871366625 0.08293675128639688 SS(ph)SMEIR ddPTM_A459_Selumetinib_30min_R1 1 SSSMEIR 7 0 E9PK89;Q8TBN0;Q8TBN0-2 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 S(0.017)S(0.885)S(0.098)MEIR 132.76 0.0034751 9329400.0 3470.3 3683.5 4079.9 3968.8 3999.4 3822.7 3830.3 3597.4 1775.2 3093.2 True False 3551.151237971668 3252.2341075873096 3525.8719892865233 3275.7235836028667 3637.654976151418 3784.247108733893 3541.3773872077772 3501.9852659979592 3012.384744521866 3490.242350319477 1.0174511915043996 0.9318075311560009 1.010208356724508 0.9385375726997942 1.0422356418368621 1.0842362016458555 1.014650855658668 1.003364498650762 0.8630875572998906 1.0 11.76911150031334 -8.129535160267379 12.595589865725325 0.9315807995503014 1.005083796868143 0.24330064270235208 0.05204473156690347 0.8841874235560112 84.55420657827604 0.035725336384637825 0.013497753019120855 7.4210411492309915e-09 8.129535160267379 0.0735029973178416 SS(ph)SMSSLTGAYTSGIPSSSR ddPTM_A459_Selumetinib_30min_R2 1 SSSMSSLTGAYTSGIPSSSR 20 0 A8CG34-2;A8CG34 A8CG34-2 POM121C Nuclear envelope pore membrane protein POM 121C 1 S(0.001)S(0.496)S(0.496)MS(0.005)S(0.001)LTGAYTSGIPSSSR 247.91 7.7423e-38 5148500.0 13704.0 11224.0 11668.0 18314.0 13768.0 8146.8 13359.0 10407.0 11263.0 10783.0 True False 12942.386541458554 12084.844709151737 10917.293583157847 15819.601606587843 12038.340752518334 9268.94775071283 13980.219970356318 10437.2826470284 13515.914714513812 10471.66677240138 1.2359433147327494 1.1540516874545674 1.042555480463811 1.510705215360865 1.1496107557820694 0.8851454073330162 1.3350520288901773 0.9967164610830053 1.2907128357193054 1.0 13.354203473479519 -6.512465378504166 24.74555017770998 1.1049669408304605 1.230418132558958 0.12575558610959559 0.1667974829700603 1025.3116114166444 2436480.517482163 0.05214291918152964 0.05544391717646952 3.072802316047799e-07 6.512465378504166 0.1254511917284975 SS(ph)SPAPADIAQTVQEDLR ddPTM_A459_Selumetinib_30min_R1 1 SSSPAPADIAQTVQEDLR 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 S(0.001)S(0.5)S(0.5)PAPADIAQTVQEDLR 286.57 2.0485999999999997e-68 59438000.0 2061.7 1872.5 2060.9 2595.4 1929.3 1686.2 2028.0 1726.2 1216.4 1569.8 True False 2109.7335986301428 1653.2668294983673 1781.0410997133736 2142.1621116919155 1754.795155645581 1669.2383589471026 1875.026327247834 1680.4155685121693 2064.14195765908 1771.299121146875 1.1910656836232942 0.9333639980738632 1.0054999059448473 1.2093734401589469 0.9906825643934108 0.9423808429749062 1.0585599602363027 0.9486910191792673 1.1653265860159159 1.0 10.790592146755197 SS(ph)SPAPADIAQTVQEDLR ddPTM_A459_Selumetinib_30min_R2 3 SSSPAPADIAQTVQEDLR 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 S(0.001)S(0.804)S(0.196)PAPADIAQTVQEDLR;S(0.001)S(0.788)S(0.211)PAPADIAQTVQEDLR;S(0.002)S(0.766)S(0.232)PAPADIAQTVQEDLR 380.03 6.296599999999994e-256 1089259800.0 249997.7 254592.1 256061.0 308239.3 296917.5 221678.6 215386.4 214824.3 188922.0 256846.9 True False 236103.82865408604 274118.4954273727 239586.31403813759 266256.57559754857 259616.0691738713 252212.81495202635 225402.29438005504 215449.4031469227 226711.67892172444 249431.06262860948 0.9465694695998348 1.0989749734399423 0.9605311845015461 1.0674555638404646 1.0408329517499864 1.0111523893379661 0.9036656942590503 0.8637633215222926 0.908915178937785 1.0 17.928281615264822 -7.22501130929978 4.904525325228865 0.9072986302996939 1.0257052153688166 0.4610225031991354 0.05332678640239377 0.15280392502159867 9.363724485427943 0.01998164289702742 0.014869274932514116 5.95646632316415e-08 7.22501130929978 0.11840658506912272 SS(ph)SPEDPERDEEVLNHVLR ddPTM_A459_Selumetinib_30min_R1 1 SSSPEDPERDEEVLNHVLR 19 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 S(0.105)S(0.448)S(0.448)PEDPERDEEVLNHVLR 76.329 0.0037506 4823800.0 1232.1 1737.4 1582.1 1771.6 1815.5 1497.3 1619.9 1636.6 668.57 1374.5 True False 1260.8055327507393 1533.9844003046533 1367.2595098532333 1462.2233170507052 1651.2883455525584 1482.2385214396252 1497.7096388110274 1593.1920515739857 1134.5144595791928 1550.930463763779 0.8129349201711029 0.9890736149330633 0.8815737015927747 0.942803917528449 1.0647081762423005 0.9557092055839479 0.9656845834186557 1.0272491828599761 0.7315056903492417 1.0 10.598918289003823 -4.752426045092696 24.91130464201612 0.953520406014339 0.8129346367041576 0.18354632547018634 0.08715360367424514 574.8614041114096 1588696.5397407934 0.020831202728605714 0.24850249864490564 1.7683733239105266e-05 4.752426045092696 -0.1405857693101814 SS(ph)SPEDPERDEEVLNHVLR ddPTM_A459_Selumetinib_30min_R2 1 SSSPEDPERDEEVLNHVLR 19 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 S(0.291)S(0.354)S(0.354)PEDPERDEEVLNHVLR 75.91199999999998 0.0049536 10617000.0 26899.0 23564.0 24888.0 28987.0 25955.0 18335.0 22332.0 25935.0 20779.0 22938.0 True False 25404.061265228644 25371.283029797905 23286.73317600554 25038.920594635903 22694.300859355983 20860.479821441513 23370.48225001849 26010.466556229636 24935.380613769215 22275.720339918662 1.1404372508530696 1.1389657727176579 1.0453863139175399 1.1240453827104984 1.0187908859085115 0.9364671266795803 1.049145971191692 1.1676599525995222 1.119397273500708 1.0 14.443184465124938 -5.254177944489615 23.246705074850773 1.0599567148396924 1.1397015473698773 0.21117895451641489 0.0633323683872154 380.2012761733987 1217150.0006877051 0.017862457816894658 0.04506313503909576 5.5695749868118765e-06 5.254177944489615 0.07974483253018483 SS(ph)SPELVTHLK ddPTM_A459_Selumetinib_30min_R1 1 SSSPELVTHLK 11 0 E9PNR6;H0YE29;Q07960 E9PNR6 ARHGAP1 Rho GTPase-activating protein 1 1 S(0.075)S(0.462)S(0.462)PELVTHLK 158.58 0.00038039 65020000.0 11138.0 12724.0 12196.0 12205.0 12874.0 10331.0 11813.0 10641.0 5639.7 9630.0 True False 11397.493729224687 11234.268164772884 10539.850187832646 10073.625866224798 11709.5489730893 10227.079519797484 10921.935899299138 10358.766113160687 9570.158992609266 10866.104304143462 1.0489033981459754 1.0338818632993458 0.9699750612382388 0.9270687621122433 1.0776216245802293 0.9411909948165779 1.005138142759626 0.9533100201523634 0.8807350569016693 1.0 13.407547180221691 -7.876704913923581 4.500103646482024 0.9335005755948861 0.9984460644762064 0.19595348206082264 0.05154504701697999 0.32395187546814136 11.071863227619266 0.029494749652143305 0.013515159363547287 1.3282966767073526e-08 7.876704913923581 0.06494548888132035 SS(ph)SPFLSK ddPTM_A459_Selumetinib_30min_R2 1 SSSPFLSK 8 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 S(0.014)S(0.472)S(0.472)PFLS(0.042)K 96.665 0.020894 9034200.0 113510.0 87620.0 109390.0 108060.0 97837.0 88358.0 106570.0 91234.0 75396.0 101630.0 True False 107201.56861653252 94340.17225729457 102351.96649482644 93342.04158610234 85545.84138612257 100528.51246593564 111525.71616444884 91499.4758353983 90477.30674025408 98695.67783354849 1.086183011958531 0.9558693382338431 1.0370460869364952 0.9457561226087821 0.8667638063178078 1.0185705663370412 1.1299959492910963 0.9270869590633273 0.9167301823778464 1.0 16.590699285865973 -4.753917136635886 24.918002140406657 0.9787086403660428 1.086183211310173 0.17807426792817183 0.06998477086369029 506.6983062192227 1678332.0238909395 0.018367501302618234 0.18712663914893307 1.76231226342191e-05 4.753917136635886 0.10747457094413027 SS(ph)SPIPLTPSK ddPTM_A459_Selumetinib_30min_R1 1 SSSPIPLTPSK 11 0 Q8N5Y2;Q8N5Y2-3;Q8N5Y2-2;A0A3B3IT59;Q8N5Y2-6;Q8N5Y2-4;A0A3B3ITL5;A0A3B3ITF3;A0A3F2YNX2;A0A3B3IRN2 Q8N5Y2 MSL3 Male-specific lethal 3 homolog 1 S(0.002)S(0.921)S(0.077)PIPLTPSK 156.01 0.00054173 31485000.0 6164.8 6740.3 8423.2 9100.1 7565.0 6587.8 7144.5 6293.7 3808.6 6371.4 True False 6308.427845387353 5951.142542519542 7279.375705325678 7510.938365033372 6880.7470857092285 6521.5327132438215 6605.584612930053 6126.770631181224 6462.916030861863 7189.231252691548 0.8774829496582913 0.8277856607118482 1.0125388166642129 1.0447484718510593 0.9570907992607933 0.907125182654578 0.9188165439047483 0.8522149887566138 0.8989717820583719 1.0 12.8116217956293 -10.027311274868632 15.358379397578657 1.0000124220557722 0.9238425308931001 0.11745854079569129 0.06404736331107794 0.0 0.0 0.06918525274556807 0.01677988851794303 9.390500175339565e-11 10.027311274868632 -0.07616989116267214 SS(ph)SPIPLTPSK ddPTM_A459_Selumetinib_30min_R2 1 SSSPIPLTPSK 11 0 Q8N5Y2;Q8N5Y2-3;Q8N5Y2-2;A0A3B3IT59;Q8N5Y2-6;Q8N5Y2-4;A0A3B3ITL5;A0A3B3ITF3;A0A3F2YNX2;A0A3B3IRN2 Q8N5Y2 MSL3 Male-specific lethal 3 homolog 1 S(0.001)S(0.935)S(0.063)PIPLTPSK 203.03 1.819e-05 38160000.0 262780.0 265870.0 274240.0 299880.0 321810.0 220930.0 256670.0 259800.0 202400.0 253670.0 True False 248175.7395916867 286261.3740932092 256595.69696993622 259035.8266781458 281381.35078209767 251361.10209714083 268605.66358195635 260555.97498779438 242885.6555285094 246345.88798618753 1.007427977062892 1.1620302511778062 1.0416073881627907 1.0515126872857312 1.142220611361999 1.020358424295008 1.0903598423246947 1.0576834755301603 0.9859537640917629 1.0 17.910325864773952 -8.171656532979881 3.950161568184186 0.9925977054638716 1.0754486885438546 0.3158449851582804 0.04661345449972874 0.25433249515406536 6.967591537131157 0.03408327524949087 0.011361112490111253 6.735090984923028e-09 8.171656532979881 0.08285098307998295 SS(ph)SPSASLTENELLWEPTPVK ddPTM_A459_Selumetinib_30min_R2 1 SSSPSASLTENELLWEPTPVK 21 0 O96028-3 O96028-3 WHSC1 Histone-lysine N-methyltransferase NSD2 1 S(0.284)S(0.334)S(0.284)PS(0.074)AS(0.02)LT(0.002)ENELLWEPTPVK 72.399 0.016712 0.0 10903.0 9224.5 11631.0 9488.0 11334.0 8355.0 10654.0 12014.0 7324.4 9988.8 True False 10297.054908167149 9931.989488557581 10882.674122875302 8195.718032287074 9910.121592754405 9505.825410861396 11149.432110500495 12048.958750975238 8789.484660835038 9700.3973899808 1.0615085644638245 1.0238744959887915 1.1218792061153735 0.8448847714993761 1.021620166096517 0.9799418548233528 1.1493789029732278 1.242109809173404 0.9060953183127722 1.0 13.243828135138262 -7.250150906554904 24.654192624522064 1.0945718269179907 1.007881172915346 0.07111674726644879 0.10625578996503461 1268.6784481671543 2770819.010407735 0.040377978752477534 0.030986645863461545 5.621459594793786e-08 7.250150906554904 -0.08669065400264464 SS(ph)SPSASLTENEVK ddPTM_A459_Selumetinib_30min_R1 1 SSSPSASLTENEVK 14 0 O96028-5 O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 S(0.013)S(0.542)S(0.445)PSASLTENEVK 178.22 7.1269e-05 7736400.0 2263.3 4009.7 4316.6 4575.4 4021.9 4228.9 3893.1 2912.8 1431.4 2497.9 True False 2316.0304863848314 3540.24245994104 3730.4294293865537 3776.392280895121 3658.119855124116 4186.361105533982 3599.4403326472075 2835.543081892158 2428.981254680372 2818.529796606434 0.8217158070045518 1.256059972899191 1.3235373398848098 1.3398447252329824 1.2978822716469292 1.485299573761627 1.2770630762821826 1.0060362268677125 0.8617901636537295 1.0 11.460727103937952 -7.828766514154202 4.23523488443826 0.933918138191969 1.2739868962390215 0.4177684733023248 0.16348356829510954 0.20771915076001335 7.22788374984252 0.09767306778654401 0.045368099667366976 1.4833153323320823e-08 7.828766514154202 0.3400687580470525 SS(ph)SPSASLTENEVK ddPTM_A459_Selumetinib_30min_R2 1 SSSPSASLTENEVK 14 0 O96028-5 O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 S(0.141)S(0.577)S(0.282)PSASLTENEVK 116.63 0.0026221 15737000.0 88933.0 88803.0 93223.0 90844.0 95367.0 75064.0 76868.0 87975.0 70474.0 97449.0 True False 83990.45988700625 95613.90455334993 87225.133673528 78470.89048535921 83386.14486820277 85403.3846368522 80442.51431105247 88230.99268495479 84570.76920808372 94635.39416709109 0.8875163529060827 1.0103397930010325 0.9216967334602179 0.8291917751915172 0.8811306340730582 0.9024465464375985 0.8500256697723555 0.9323255158547922 0.8936484066285287 1.0 16.530092240061542 -10.779579823507763 13.244605752448308 1.0000000000675686 0.9015329691209321 0.2887209119881037 0.04664295791393349 0.0 0.0 0.047782706906958426 0.011589008685607069 1.6611933216765858e-11 10.779579823507763 -0.09846703094663656 SS(ph)SPTQYGLTK ddPTM_A459_Selumetinib_30min_R1 2 SSSPTQYGLTK 11 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 S(0.003)S(0.757)S(0.239)PTQYGLTK;S(0.063)S(0.73)S(0.207)PTQYGLTK 219.89 1.2845e-05 183594000.0 15625.900000000001 16532.2 18853.8 20015.7 17779.5 14305.7 17204.800000000003 14591.4 8448.8 12747.0 True False 15989.953067291442 14596.602338388742 16293.557516510258 16520.333736222507 16171.34736422567 14161.797646536343 15907.02808433606 14204.388672453051 14336.99652406283 14383.201616294571 1.1117102779937813 1.0148368025274992 1.1328185442420182 1.1485852855950238 1.1243218162154751 0.9846067672786146 1.1059448729631352 0.9875679317712585 0.9967875655598545 1.0 13.812097226525312 -7.765910198476631 24.978527482982198 0.9941332817560141 1.0874477844008104 0.436586376964855 0.04901020974983892 114.67798142646198 640689.943162737 0.026907219396181205 0.013613104117955188 1.7143117487867563e-08 7.765910198476631 0.09331450264479624 SS(ph)SPTSYWK ddPTM_A459_Selumetinib_30min_R1 1 SSSPTSYWK 9 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 S(0.04)S(0.702)S(0.257)PTSYWK 148.32 0.0015449 31775000.0 4845.9 5702.4 3982.6 4283.0 5349.9 3402.5 5444.6 5146.7 2212.9 5052.6 True False 4958.800041520012 5034.760357026159 3441.7847948558806 3535.054451867333 4866.002489601562 3368.273939222821 5033.909438527392 5010.19279716231 3755.1296761787066 5701.150426491715 0.8697893706641734 0.8831130526973959 0.603700049530851 0.6200598453675041 0.8535123835692101 0.5908060105853998 0.882963798874025 0.8788038242038466 0.6586617428527456 1.0 12.477037352558343 -10.434454460758596 5.127342149548656 1.0000006304276254 0.7599173295383985 0.2590266685861351 0.12169585222469768 8.920002871865217e-07 1.8946846371426696e-07 0.11984200949796144 0.029065880452417942 3.6774395224397915e-11 10.434454460758596 -0.2400833008892269 SS(ph)SPVGLAK ddPTM_A459_Selumetinib_30min_R2 1 SSSPVGLAK 9 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.018)S(0.491)S(0.491)PVGLAK 137.46 0.0025514 50122000.0 398350.0 375330.0 429480.0 426130.0 380800.0 320690.0 356670.0 332080.0 283640.0 358780.0 True False 376211.3017213964 404116.60412383394 401847.72438246745 368090.35888474877 332960.49960480665 364862.1365660256 373255.8617281971 333046.2978211967 340375.9255637667 348421.08917761035 1.0797604203849434 1.1598511590606744 1.15333926924734 1.0564525808514187 0.9556267113184915 1.0471872911803979 1.0712780406295297 0.9558729599499753 0.9769096536813172 1.0 18.410472424237966 -5.944977959255322 4.34597202940345 1.0045751297347199 1.1327406804840865 0.6785367229421664 0.03991114449723877 0.12694839562210325 5.006377620740821 0.012110833280979451 0.01815842369800954 1.1350684197162301e-06 5.944977959255322 0.12816555074936664 SS(ph)SQENLLDEVMK ddPTM_A459_Selumetinib_30min_R2 1 SSSQENLLDEVMK 13 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.031)S(0.572)S(0.396)QENLLDEVMK 131.61 0.0057166000000000005 3425500.0 27265.0 29142.0 29928.0 29004.0 25153.0 20502.0 22083.0 23953.0 21427.0 22832.0 True False 25749.72045044275 31377.097693701013 28002.465063142638 25053.605165309244 21993.05526932696 23325.964401374098 23109.90325663435 24022.699264367395 25712.99872040199 22172.780835339723 1.161321200153748 1.4151178387011853 1.2629207527506594 1.1299261626840222 0.9918943154966692 1.052008973281168 1.042264541748458 1.0834319539243003 1.1596650375680324 1.0 14.436502099044896 -5.826577996527699 3.18213559838093 1.0585226712082763 1.2983588714795125 0.6578809744951223 0.07228846462517519 0.1371653263656755 2.800961885446364 0.020479867438020275 0.03376383661809219 1.49080899159279e-06 5.826577996527699 0.2398362002712362 SS(ph)SQGPLSSIR ddPTM_A459_Selumetinib_30min_R2 1 SSSQGPLSSIR 11 0 A0A0U1RQE4 A0A0U1RQE4 1 S(0.029)S(0.759)S(0.211)QGPLSSIR 117.27 0.005647600000000001 14306000.0 37597.0 30882.0 39920.0 39411.0 36715.0 31374.0 35427.0 31236.0 34786.0 34765.0 True False 35507.50925271577 33250.5500987192 37351.590661609676 34043.15381223291 32102.533463735486 35695.4837151844 37074.42569726874 31326.89158860183 41744.172002048996 33761.24411968227 1.0517239568199281 0.9848733648809659 1.1063452084052285 1.0083500978681734 0.9508693859128319 1.0572917155731976 1.098135648255182 0.9278950585336619 1.2364524202386489 1.0 15.043080448648583 -6.965103076150616 24.99813786806482 1.062198131108914 1.020710786290549 0.0650584531891708 0.08256632778113239 582.8477187224933 417516.68684516574 0.02769457712416439 0.02442421673705093 1.0836696835915864e-07 6.965103076150616 -0.041487344818365024 SS(ph)TDFSELEQPR ddPTM_A459_Selumetinib_30min_R1 1 SSTDFSELEQPR 12 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 S(0.315)S(0.672)T(0.013)DFSELEQPR 241.35 2.0078e-13 30784000.0 2393.8 2833.3 2879.6 2875.2 2494.3 2393.9 2546.3 2441.0 1275.0 1877.2 True False 2449.5708824760322 2501.575918834566 2488.566136510568 2373.10029418841 2268.6910054044315 2369.8195394872914 2354.230540962108 2376.2567505145416 2163.5818776844176 2118.156905476439 1.1564633744283679 1.1810153970967907 1.1748733675378087 1.1203609553441585 1.0710684366860597 1.1188120829765658 1.1114523833788266 1.1218511453853075 1.0214455180777842 1.0 11.04859374763177 -1.5228787455810913 0.05245133703112591 0.7726815780868355 1.756878943792308 0.7478049729796794 0.028911669421065166 232.20794259820062 0.9206841193720702 3.926812659206928 18.209723187686173 0.02999999997922467 1.5228787455810913 0.9841973657054726 SS(ph)TDSLPGPISR ddPTM_A459_Selumetinib_30min_R1 1 SSTDSLPGPISR 12 0 Q9HCD5 Q9HCD5 NCOA5 Nuclear receptor coactivator 5 1 S(0.096)S(0.881)T(0.023)DSLPGPISR 114.24 0.005619399999999999 6845200.0 1313.6 1613.5 1661.9 1578.7 1714.3 1265.5 1424.2 1260.4 1025.7 1155.5 True False 1344.204324179345 1424.5906699042005 1436.2231081632563 1303.0096808692415 1559.2418676842465 1252.770218982066 1316.771447370002 1226.970097643806 1740.5379858360063 1303.8196805231332 1.0309741019095586 1.0926285982526434 1.1015504134643823 0.999378748713498 1.1959030002205748 0.9608462256678126 1.0099337101904093 0.941058120208392 1.3349529937588056 1.0 10.3485286419585 SS(ph)TPSDINSPR ddPTM_A459_Selumetinib_30min_R2 1 SSTPSDINSPR 11 0 Q674X7-3;A0A1B0GWK2;Q674X7-4;Q674X7-2;Q674X7;Q674X7-5 Q674X7-3 KAZN Kazrin 1 S(0.26)S(0.48)T(0.26)PSDINSPR 176.87 6.794800000000001e-05 3716900.0 25405.0 23990.0 29388.0 30493.0 29601.0 17072.0 18284.0 22796.0 18980.0 20540.0 True False 23993.091804272794 25829.955859991995 27497.208075235096 26339.80079664099 25882.257743702434 19423.51303581399 19134.242229058676 22862.332585919034 22776.530345509393 19946.956830670893 1.2028447250349723 1.294932158286685 1.3785164478300151 1.3204921943852765 1.2975542065597339 0.9737582128792677 0.9592562109342629 1.1461564177431514 1.1418548974090967 1.0 14.28388104077469 -6.749973133260856 24.79251659208282 1.048030623054088 1.3042756294759117 0.7628620058558886 0.07094455046661131 103.21767071683867 223178.57789400374 0.025545457950869543 0.02533062008030645 1.778389423057405e-07 6.749973133260856 0.2562450064218238 SS(ph)TQTLEDSWR ddPTM_A459_Selumetinib_30min_R1 1 SSTQTLEDSWR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.351)S(0.639)T(0.009)QTLEDSWR 195.71 2.0661e-05 6943200.0 1440.6 1545.5 1396.3 1651.7 2084.8 1500.1 2213.8 2264.1 1241.7 1094.4 True False 1474.1631770803642 1364.5521415165424 1206.6901293268886 1363.2616012489552 1896.2302081013358 1485.0103559818235 2046.8112836593946 2204.0487131667246 2107.0742098201904 1234.8769003587333 1.193773384741522 1.105010662293657 0.9771744284603134 1.1039655862482536 1.5355621338049796 1.2025574011064797 1.6575022846931489 1.7848327331464744 1.706303040576824 1.0 10.270151517489404 -6.514358996020759 1.2789067827026883 1.5705143173195861 1.078679381177652 0.3588717132896275 0.2358719805875819 0.42180572304157177 1.4340266560567458 0.10184528375557586 0.11527564220207998 3.0594334027183817e-07 6.514358996020759 -0.4918349361419341 SS(ph)TQTLEDSWR ddPTM_A459_Selumetinib_30min_R2 1 SSTQTLEDSWR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 S(0.053)S(0.779)T(0.168)QTLEDSWR 101.45 0.015259 5672200.0 15769.0 21483.0 23261.0 24302.0 21778.0 19569.0 20390.0 17606.0 20191.0 32213.0 True False 14892.62210830851 23130.67702126754 21764.412584661877 20992.025676711695 19042.052942209757 22264.452120304835 21338.175402018514 17657.230545169794 24229.76418367651 31282.92699057457 0.4760622979044001 0.7394025830203397 0.6957281392249329 0.6710377735125781 0.6087043245009348 0.711712562159322 0.6821029057941933 0.5644366510361979 0.7745363530393703 1.0 14.933087884433501 -8.574255257548897 5.131625877022368 0.9999485815763319 0.6523985208092202 0.6851465896569269 0.07416557678920142 0.16696110520734908 14.291870534113203 0.06831187182831688 0.017756696614110248 2.6652916729489123e-09 8.574255257548897 -0.3475500607671117 SS(ph)TSSEPTPTVK ddPTM_A459_Selumetinib_30min_R2 1 SSTSSEPTPTVK 12 0 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 S(0.488)S(0.511)TSSEPTPTVK 112.84 0.006206100000000001 5858200.0 25226.0 19875.0 21631.0 25451.0 24711.0 21345.0 26233.0 36701.0 31413.0 30325.0 True False 23824.039907679013 21399.348591802453 20239.285010052055 21984.529894576128 21606.583260857093 24285.079999381993 27452.886479703346 36807.793833822376 37696.477752554594 29449.438456187687 0.8089811268599347 0.7266470844134615 0.6872553797642799 0.7465177961638487 0.7336840494599409 0.8246364369735343 0.9322040731114573 1.2498640301268158 1.280040629930385 1.0 14.845952504464368 -7.499248534050029 2.2489362926090988 1.1998819852548006 0.7447347599434283 0.8408266468142086 0.08160337421159662 0.10678285679316159 1.069305633148736 0.044444768863716094 0.023950966496826914 3.1677541310478514e-08 7.499248534050029 -0.4551472253113723 SS(ph)TSSIDSNISSK ddPTM_A459_Selumetinib_30min_R2 1 SSTSSIDSNISSK 13 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;E9PNV5 A0A0A0MTL4 NAV2 Neuron navigator 2 1 S(0.368)S(0.622)T(0.006)S(0.003)S(0.001)IDSNISSK 86.944 0.037879 0.0 12502.0 11368.0 15039.0 13860.0 14297.0 9853.6 12633.0 11783.0 10869.0 12857.0 True False 11807.188889471303 12239.88904611876 14071.407113225136 11972.244090166401 12500.883043198317 11210.84395792506 13220.459531814598 11817.286579219337 13043.103705234016 12485.78500350223 0.9456505046466376 0.9803059273153834 1.1269941865311748 0.9588699538561828 1.0012092182983972 0.8978885952930031 1.0588408760927963 0.9464592395195512 1.0446362564769023 1.0 13.607998908469336 -8.298846039884635 24.942523086647633 1.022318098014214 0.992425439573269 0.041582040151483035 0.06172841167860861 2682.4648627762995 1788627.3404806205 0.05828449690493103 0.015049965231611158 5.025207046879357e-09 8.298846039884635 -0.029892658440944908 SS(ph)TSSIDSNVSSK ddPTM_A459_Selumetinib_30min_R2 1 SSTSSIDSNVSSK 13 0 Q8IVL0-3;Q8IVL0-2;Q8IVL0;A0A2R8YFX5;H0YHA8 Q8IVL0-3 NAV3 Neuron navigator 3 1 S(0.364)S(0.616)T(0.011)S(0.006)S(0.003)IDSNVSSK 180.95 0.00011365 3916500.0 19794.0 19260.0 18618.0 19895.0 19860.0 14773.0 16458.0 15443.0 14661.0 18397.0 True False 18693.92872166014 20737.18006933915 17420.138149745708 17185.266679210716 17365.009249347335 16807.84665405811 17223.329610908324 15487.936573273719 17593.609662566552 17865.830808853585 1.04635093221616 1.16071736552339 0.9750533482670725 0.9619069419763222 0.9719676311242093 0.9407816985330915 0.9640374296152596 0.8669026780214734 0.9847630289797589 1.0 14.124915384205542 -5.3770576155707275 5.4486777341217625 0.9519865572929344 1.1023692087198076 0.6518664948628371 0.04253068500532234 0.11632024566593402 4.714031780103951 0.010742562637257317 0.022940733850726855 4.197033004622415e-06 5.3770576155707275 0.15038265142687324 SS(ph)VDLEESSTK ddPTM_A459_Selumetinib_30min_R1 1 SSVDLEESSTK 11 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 S(0.058)S(0.942)VDLEESSTK 248.19 2.5257e-15 17921000.0 3600.7 5103.8 4468.3 4998.6 4488.8 4161.6 4957.1 4107.0 2426.2 4033.6 True False 3684.5893042574385 4506.24472330775 3861.5294026150054 4125.688345342997 4082.7888325620092 4119.738082430473 4583.181956015894 3998.0690185838716 4117.084197363088 4551.35185059118 0.8095593189040842 0.9900892902231738 0.8484357020460696 0.9064753683693137 0.8970497044810305 0.9051680067088981 1.006993549712176 0.8784354956131458 0.9045849085098344 1.0 12.152079405462047 -7.021947612454798 24.589983899412236 0.9400456377950002 0.8951023006149355 0.18113177887971765 0.05637451710426984 1330.502334824068 1490684.1925591591 0.020418634530898636 0.015966965420435585 9.507194689685198e-08 7.021947612454798 -0.04494333718006471 SS(ph)VSSVGAR ddPTM_A459_Selumetinib_30min_R1 1 SSVSSVGAR 9 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67;Q8N4M4;E9PRA3;E9PRP1;E9PS62;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 S(0.223)S(0.775)VS(0.001)S(0.001)VGAR 120.27 0.0038104 0.0 1516.9 1666.7 1493.7 1581.6 1387.8 1294.7 1355.3 1620.5 856.25 1405.3 True False 1552.2408186264086 1471.5619891721915 1290.8637443067905 1305.403250308983 1262.2737350359898 1281.6764934935445 1253.0686298417097 1577.5190758741576 1452.9937119743386 1585.6839437811846 0.9789093373329945 0.9280298226790009 0.8140737940680834 0.8232430273564788 0.7960437134943813 0.8082799214308047 0.7902385811220815 0.9948508856767779 0.9163198742553728 1.0 10.63088952847925 -7.769386716444352 24.999180791311247 0.9666890608022741 0.8456201855982584 0.4543693248349596 0.061165582847710294 185.2546854297072 582727.2882276829 0.035712296001866047 0.017641470001830837 1.7006435001902906e-08 7.769386716444352 -0.12106887520401577 SS(ph)VTDENWLSPR ddPTM_A459_Selumetinib_30min_R2 1 SSVTDENWLSPR 12 0 H3BRS1;Q12968;I3L3K7;H3BR83;Q12968-5;Q12968-6;Q12968-4;Q12968-3;Q12968-2 H3BRS1 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 1 S(0.166)S(0.834)VTDENWLSPR 159.0 0.00037608 0.0 5499.3 4427.3 4671.7 6992.5 7475.8 4615.7 6348.2 5841.2 7199.5 5844.2 True False 5193.6709214421335 4766.859673986768 4371.127908162371 6040.109437264686 6536.623169500036 5251.470777847156 6643.403878719661 5858.196924937282 8639.60117083745 5675.462760944837 0.9151096818363238 0.8399067837761995 0.7701799998128569 1.064249681775578 1.1517339545386842 0.925293848104274 1.170548404340809 1.0321972272023197 1.5222725502297456 1.0 12.470522315074708 -6.29229336073307 0.6733294532293815 1.1897819083187087 0.8187766936211389 0.38472260669931113 0.1580419333542967 0.8730955067438464 0.8504849963309185 0.10141281489798268 0.18163235820818013 5.101602763894697e-07 6.29229336073307 -0.37100521469756975 SSAMSS(ph)DGSLAENGVMAEEKPAPQMNGSTGDAR ddPTM_A459_Selumetinib_30min_R2 1 SSAMSSDGSLAENGVMAEEKPAPQMNGSTGDAR 33 1 Q9NZB2-4;Q9NZB2;Q9NZB2-6;A0A0C4DG79 Q9NZB2-4 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 S(0.02)S(0.02)AMS(0.215)S(0.544)DGS(0.173)LAENGVMAEEKPAPQMNGS(0.014)T(0.014)GDAR 44.483 0.011851 4997600.0 11963.0 8634.7 11234.0 14765.0 12869.0 11200.0 14685.0 14220.0 11780.0 8723.2 True False 11298.144351683353 9296.953725063488 10511.216670654385 12753.981528954324 11252.281169680302 12742.698336522768 15367.881597775457 14261.377845752275 14136.329160700776 8471.338550404498 1.3336905713848348 1.097459825238547 1.240797615171747 1.5055450154740107 1.3282766475131627 1.5042130899035213 1.814103108539046 1.6834857633061198 1.6687243788675852 1.0 13.04837423148698 -6.154268161449703 1.1022781419627088 1.5866986929382336 1.2043630103383807 0.21148841538036822 0.2227697529234815 0.6226158625057369 1.5613225717401549 0.09059222112741777 0.15317246525847675 7.010223083269319e-07 6.154268161449703 -0.38233568259985296 SSASAPDVDDPEAFPALA ddPTM_A459_Selumetinib_30min_R2 1 SSASAPDVDDPEAFPALA 18 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 106.35 0.03734 0.0 7394.5 6018.6 6560.4 7501.3 7939.8 6276.4 5325.9 5358.1 4757.5 6403.6 False True 6983.543292528837 6480.207267150811 6138.311006423448 6479.609999535728 6942.3313412874095 7140.917128513526 5573.564903070641 5373.691183918795 5709.132935656527 6218.711429449082 1.122988801097579 1.0420498427477114 0.9870712085714586 1.0419537991184389 1.1163617125585827 1.1482953035410655 0.8962572015605498 0.8641165046622613 0.9180572214077315 1.0 12.602399957151047 -7.27625812278455 24.86598522515811 0.9082840904164547 1.071072661754808 0.660019395809004 0.05482603989166188 484.2625574583218 812593.9196887814 0.024274502180251015 0.01644120452108623 5.2934873212914364e-08 7.27625812278455 0.16278857133835334 SSATIQNET(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SSATIQNETPK 11 0 F5GX09;Q5HYJ3-3;Q5HYJ3-2;Q5HYJ3 F5GX09 FAM76B Protein FAM76B 1 SSAT(0.001)IQNET(0.999)PK;SSAT(0.001)IQNET(0.999)PK 172.57 0.00056105 57423000.0 6906.200000000001 9310.3 8204.6 8147.400000000001 5691.0 7685.4 6873.5 5844.3 4801.5 6548.5 True False 7067.1010228740815 8220.245747758956 7090.46038464183 6724.609535639485 5176.2500548276585 7608.091853784882 6355.026361113405 5689.290179038156 8147.794812315083 7389.063762791631 0.9564271265950058 1.1124881326850669 0.9595884691571552 0.910075992238953 0.700528540691878 1.0296421979867312 0.8600584005127653 0.7699608991990494 1.102682974985832 1.0 12.851175862789256 -5.551079806189282 3.8030528716305207 0.8957119091670181 1.0359962638434865 0.13885324594828863 0.11813186671927028 0.34610856904325116 10.832573949196064 0.03145686171991839 0.06144540095169819 2.8113841614520805e-06 5.551079806189282 0.14028435467646838 SSATSGDIWPGLS(ph)AYDNSPR ddPTM_A459_Selumetinib_30min_R2 4 SSATSGDIWPGLSAYDNSPR 20 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSATSGDIWPGLS(0.708)AY(0.014)DNS(0.278)PR;SSATSGDIWPGLS(0.509)AY(0.056)DNS(0.435)PR;SSATSGDIWPGLS(0.973)AY(0.011)DNS(0.015)PR;SSATSGDIWPGLS(0.705)AY(0.024)DNS(0.271)PR 132.5 0.00014352 3866700.0 32029.300000000003 24063.1 32896.6 38359.299999999996 39646.3 27462.7 37125.4 38935.1 37997.0 29370.5 True False 30249.239729446752 25908.66239493845 30780.068571109925 33134.6971665166 34665.577351581 31245.4376434307 38851.80466258448 39048.39469494722 45597.461724885165 28522.49735127651 1.0605396630212314 0.9083588325332571 1.0791505453407424 1.1617039264983462 1.2153766524946161 1.0954664052947078 1.3621459644327283 1.3690384195337522 1.5986489949781508 1.0 14.799812685264163 -6.421112346875606 0.7743153570171464 1.3538256841141783 0.986220309603202 0.37472389419001595 0.1548097947144551 0.6568729138408693 0.8700773145510506 0.09183214686236811 0.13108735493621146 3.7921687333813853e-07 6.421112346875606 -0.3676053745109763 SSATSGDIWPGLSAYDNS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 SSATSGDIWPGLSAYDNSPR 20 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSATSGDIWPGLSAYDNS(1)PR;SSATSGDIWPGLSAYDNS(1)PR;SSATSGDIWPGLS(0.008)AY(0.001)DNS(0.991)PR 288.96 1.2275999999999992e-85 114322000.0 8962.7 10345.800000000001 7409.2 6606.9 9430.9 7385.9 11396.199999999999 10499.1 5644.2 10388.199999999999 True False 9171.513471621663 9134.508926368066 6403.071335822374 5453.128941873049 8577.876760160629 7311.604551860641 10536.575458866744 10220.629762116847 9577.795163942268 11721.62665963687 0.7824437459012018 0.7792867996574674 0.5462613271817631 0.4652194699777262 0.7317991784961326 0.6237704683973573 0.8989004482755948 0.8719463653719096 0.8171046086054906 1.0 13.516885172086738 -7.263519942752792 24.89269588654298 0.8863167318529246 0.6504049843597055 0.572725137559222 0.10227307151158135 146.45278444046704 1752201.5908374565 0.04440638278216091 0.03160233372469636 5.4510486396136285e-08 7.263519942752792 -0.23591174749321908 SSATSGDIWPGLSAYDNS(ph)PR ddPTM_A459_Selumetinib_30min_R2 7 SSATSGDIWPGLSAYDNSPR 20 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSATSGDIWPGLSAYDNS(1)PR;SSATSGDIWPGLS(0.001)AY(0.002)DNS(0.997)PR;SSATSGDIWPGLSAYDNS(1)PR;SSATSGDIWPGLS(0.002)AY(0.001)DNS(0.997)PR;SSATSGDIWPGLS(0.004)AY(0.001)DNS(0.995)PR;SSATSGDIWPGLS(0.001)AY(0.001)DNS(0.998)PR;SSATSGDIWPGLS(0.001)AYDNS(0.998)PR 213.48 3.3989e-17 82509400.0 420929.69999999995 289245.9 375873.2 451429.0 474638.8 416330.1 556672.3 591503.6 537785.3999999999 350908.6 True False 397536.112389097 311430.13045784325 351689.9275317963 389943.59144153947 415010.43061929056 473675.7922066393 582558.6649752362 593224.7775473075 645357.506979551 340776.9569479637 1.1665580793650916 0.9138825971305282 1.0320237925755613 1.1442780490028364 1.217835954450002 1.3899877399250593 1.7095013412664293 1.7408007362360842 1.8937827039699064 1.0 18.37846825946992 -6.797316483210635 1.6296204612909788 1.6478348251814048 1.0490782845699873 0.49719278977619263 0.232817115358558 0.2684866078781729 1.4770581411906354 0.0978143688815632 0.08649917300377688 1.5947166066272927e-07 6.797316483210635 -0.5987565406114175 SSATVFQNPMGIIPSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SSATVFQNPMGIIPSSPK 18 0 P48552 P48552 NRIP1 Nuclear receptor-interacting protein 1 1 SSATVFQNPMGIIPS(0.24)S(0.76)PK 93.228 0.004693 8231400.0 1460.5 1473.3 1880.8 1747.7 1109.8 1599.4 1411.1 1777.9 940.61 1335.5 True False 1494.5268083617048 1300.8053510814118 1625.397690494887 1442.4970033921397 1009.4187859511043 1583.3114881390086 1304.6595909168718 1730.744316566902 1596.146470563717 1506.9244338716092 0.9917728950229758 0.8632187001835031 1.0786192419210396 0.9572457456848439 0.6698536192406761 1.050690699911969 0.8657763863878191 1.1485276087270362 1.0592080363730498 1.0 10.55739135812598 -7.7588528704698305 24.9998935370294 1.0779008720332772 0.9250446078734079 0.2516221095802078 0.11345723371921639 89.89233144746439 868881.1408181507 0.05576052472562829 0.030287937914049157 1.7423970596639974e-08 7.7588528704698305 -0.1528562641598693 SSAWAEGGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 SSAWAEGGSPR 11 0 Q8N9B5-2;Q8N9B5 Q8N9B5-2 JMY Junction-mediating and -regulatory protein 1 SSAWAEGGS(1)PR;SSAWAEGGS(1)PR;SSAWAEGGS(1)PR;SSAWAEGGS(1)PR 145.23 0.00070555 40653500.0 6014.5 7444.2 7640.799999999999 7825.799999999999 7517.0 6452.999999999999 7062.8 6643.599999999999 3735.5099999999998 5334.4 True False 6154.626147820245 6572.629603285307 6603.221327910108 6459.170938459813 6837.08867723414 6388.088678855214 6530.047309707098 6467.390146545847 6338.887639144253 6019.122201456163 1.0225122437838694 1.0919581598950157 1.0970405828133276 1.0731084570599336 1.1358946451660497 1.0612990507668694 1.0848836576415297 1.0744739731287127 1.053124928683244 1.0 12.555337391589923 -8.693867798229247 1.302307298344806 1.0000404872281097 1.0834383614060568 0.4501043525613575 0.027062968222985415 0.6111171888693657 2.067096447455322 0.025249176147137734 0.007617716952004788 2.0236350912425213e-09 8.693867798229247 0.08339787417794708 SSAWAEGGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SSAWAEGGSPR 11 0 Q8N9B5-2;Q8N9B5 Q8N9B5-2 JMY Junction-mediating and -regulatory protein 1 SSAWAEGGS(1)PR;SSAWAEGGS(1)PR;SSAWAEGGS(1)PR;SSAWAEGGS(1)PR 138.63 0.0012353 37533700.0 119557.0 104435.0 126147.0 127241.0 137265.0 88394.0 99894.0 105289.0 104739.0 97342.0 True False 112912.50056459133 112444.82868854773 118030.83935846879 109910.55629703184 120020.54353533036 100569.47113916017 104539.26893620568 105595.37355846773 125689.72665217663 94531.48353511037 1.1944433361468827 1.18949607563055 1.2485876127674482 1.1626873099501231 1.2696356710698715 1.0638727689257856 1.1058672203888378 1.1170392086277592 1.3296070467940306 1.0 16.528507275818825 -6.7585082055038255 24.999998298577655 1.129504076239475 1.2108511608868036 0.22191485103042907 0.08352169803063231 134.61837397411497 1148161.1855864362 0.027593587195701607 0.026442183129458827 1.7437804103928318e-07 6.7585082055038255 0.08134708464732854 SSCS(ph)TPLSQANR ddPTM_A459_Selumetinib_30min_R1 1 SSCSTPLSQANR 12 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 SSCS(0.5)T(0.5)PLSQANR 158.34 0.0004531000000000001 28762000.0 4969.5 5451.4 5787.3 6136.9 5568.6 4961.0 5782.6 4543.1 3079.1 4383.0 True False 5085.27968103628 4813.147553712897 5001.41644736339 5065.205618880372 5064.9211132161845 4911.096844227601 5346.4138264020285 4422.602229931432 5225.007811433793 4945.600744035384 1.0282430677748007 0.9732179775162337 1.0112859299035253 1.0241840943163956 1.02412656729816 0.9930233147410056 1.0810443671277028 0.8942497501977466 1.0564960824497178 1.0 12.271930061015523 -13.396248334475441 15.190391919932782 1.0000493571158051 1.0071873737521577 0.0 0.04804505700798017 0.0 0.0 0.0 0.010164113170748947 4.015611280125134e-14 13.396248334475441 0.0071380166363526065 SSCS(ph)TPLSQANR ddPTM_A459_Selumetinib_30min_R2 1 SSCSTPLSQANR 12 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.002)S(0.001)CS(0.944)T(0.052)PLSQANR 163.71 0.00050341 20792000.0 43418.0 41408.0 42469.0 50363.0 49438.0 42669.0 48783.0 45827.0 35460.0 43101.0 True False 41005.00137602503 44583.86045229467 39736.590776751036 43503.47251897912 43227.15645867237 48546.26743938302 51051.50616168065 45960.34898293176 42552.99083518246 41856.56214015322 0.9796552626258026 1.0651582015505554 0.9493515173008324 1.0393465276319485 1.0327450284600495 1.1598245282742017 1.219677478306482 1.0980440493186554 1.016638459047289 1.0 15.353166201247447 -6.617381189284248 5.867854346892532 1.1121964913587228 1.0114814604511329 0.2865485662809437 0.06657687347108918 0.2522501822869921 12.873377755636664 0.02273016614100484 0.022704684305792592 2.413341664472876e-07 6.617381189284248 -0.10071503090758993 SSCST(ph)PLSQANR ddPTM_A459_Selumetinib_30min_R1 2 SSCSTPLSQANR 12 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.004)S(0.004)CS(0.207)T(0.785)PLSQANR;S(0.001)S(0.001)CS(0.227)T(0.77)PLSQANR 132.86 0.0042643 30025100.0 5758.7 6650.299999999999 6550.2 6571.6 6616.400000000001 5307.799999999999 6752.4 5534.9 3730.6 5342.1 True False 5892.866505520399 5871.679784359406 5660.7188176731215 5423.993424209982 6017.947788220293 5254.408351096808 6243.061031611572 5388.096472110998 6330.555727756461 6027.81057146052 0.9776130878135038 0.9740982591854601 0.939100316867049 0.899828115019176 0.9983637867973284 0.8716943388988551 1.0357095594825398 0.8938728926920274 1.0502247296438494 1.0 12.557418364519423 -8.276428372722146 24.995499114465456 1.0251123712240466 0.94965451351835 0.27792608931839713 0.04919547470354684 1129.9608262803183 1884292.4216430583 0.042736514196797554 0.01121506163993268 5.291412601713636e-09 8.276428372722146 -0.07545785770569668 SSCST(ph)PLSQANR ddPTM_A459_Selumetinib_30min_R2 2 SSCSTPLSQANR 12 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 SSCS(0.027)T(0.973)PLSQANR;SSCS(0.001)T(0.998)PLSQANR 138.02 0.0029833000000000004 29528000.0 90339.0 88598.0 101495.0 106892.0 103280.0 81855.0 95277.0 93504.0 74115.0 95809.0 True False 85318.32003567016 95393.18171252913 94964.92219940077 92333.12520101489 90305.04306508515 93129.78324429196 99707.56928779378 93776.08115957958 88940.0709461238 93042.74522832276 0.9169798228362973 1.0252618995542155 1.020659074131584 0.992373182610138 0.9705758664308602 1.0009354626817557 1.0716318509639395 1.007881709954465 0.955905489760312 1.0 16.505606043738688 -7.001208545205638 24.984052064817302 1.0133361534879919 0.9893677490872379 0.0694635286982288 0.038436948157533624 131.17779149884032 2711871.524149897 0.013952202967599433 0.01217032689644461 9.97221090163399e-08 7.001208545205638 -0.023968404400753984 SSDEENGPPS(ph)SPDLDR ddPTM_A459_Selumetinib_30min_R2 1 SSDEENGPPSSPDLDR 16 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 SSDEENGPPS(0.5)S(0.5)PDLDR 343.59 8.672299999999995e-154 124100000.0 77834.0 82533.0 93351.0 99237.0 91077.0 73307.0 68931.0 81689.0 73096.0 89995.0 True False 73508.29787418898 88863.01571457794 87344.89829288366 85720.74940662635 79635.0930212894 83404.37383531015 72136.42808418517 81926.70146565804 87717.24247288483 87396.61051490904 0.8410886582569372 1.0167787422307268 0.9994083040323793 0.9808246441319733 0.9111920079292366 0.954320463275657 0.8253915988181186 0.9374128010568799 1.0036687001485154 1.0 16.41528970860994 -3.1476943399908444 15.328872327217132 0.9454320535670282 0.4416431542020489 0.0 0.0649911815032244 0.0 0.0 0.014962103073439663 0.0 0.0007117142477320967 3.1476943399908444 -0.5037888993649793 SSDEENGPPSS(ph)PDLDR ddPTM_A459_Selumetinib_30min_R1 3 SSDEENGPPSSPDLDR 16 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 SSDEENGPPSS(1)PDLDR;SSDEENGPPS(0.026)S(0.974)PDLDR;SSDEENGPPS(0.024)S(0.976)PDLDR 329.97 1.4295999999999991e-134 137846000.0 15750.119999999999 18230.6 18739.37 18867.16 18815.08 16075.63 18437.3 16693.51 9751.489999999998 13720.810000000001 True False 16117.067151601395 16096.15287682399 16194.666481991268 15572.36468645652 17113.25933607218 15913.923757704202 17046.5596170446 16250.743886637458 16547.566309349662 15482.009615507235 1.0410190635366916 1.0396681875653668 1.0460312894890735 1.0058361332406602 1.1053642105305914 1.0278978086775215 1.1010560024436535 1.0496533906270304 1.068825476815047 1.0 13.918305129723722 -6.24024661120132 24.90824731629164 1.0618499017884189 1.0345259700564147 0.13607284233741967 0.031032669111726374 1444.5878493958253 1697851.344701126 0.008467374104756138 0.010917232737039071 5.751132703946329e-07 6.24024661120132 -0.027323931732004203 SSDEENGPPSS(ph)PDLDR ddPTM_A459_Selumetinib_30min_R2 1 SSDEENGPPSSPDLDR 16 0 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 1 SSDEENGPPSS(1)PDLDR 335.98 2.810499999999998e-135 109220000.0 78978.0 76759.0 83403.0 96290.0 97429.0 71179.0 72591.0 77210.0 65040.0 89513.0 True False 74588.71893398369 82646.16848091397 78036.94178232043 83175.13589048502 85189.09799368882 80983.26115137081 75966.62533633759 77434.66831719644 78049.81736943788 86928.52710729513 0.8580465057451103 0.950737016157015 0.8977138389334506 0.9568221003885488 0.9799901232485011 0.9316074233193192 0.8738975324242252 0.8907854635753749 0.8978619558698109 1.0 16.407542079747607 -5.049450039574135 0.0048415420740765165 1.8263852569927934 7.075140426193957e-07 0.12037832132900117 0.0420457265563772 92345.39134380841 76.19754400235962 13913.373109516982 14840.266254955439 8.923802714425887e-06 5.049450039574135 -1.8263845494787507 SSDGRPDS(ph)GGTLR ddPTM_A459_Selumetinib_30min_R1 1 SSDGRPDSGGTLR 13 1 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 SSDGRPDS(0.628)GGT(0.372)LR 129.29 0.0082602 4652100.0 1780.6 2209.3 1871.3 2170.4 2037.8 1790.6 2021.4 2071.8 1188.0 1442.0 True False 1822.0845155555296 1950.6341289242957 1617.1877383151223 1791.3803834538555 1853.4813498028104 1772.5881897347194 1868.9241705615243 2016.8491338451577 2015.949231913011 1627.0947462694562 1.1198392224749905 1.1988448327281733 0.9939112286011319 1.1009686974658774 1.1391354769305262 1.0894191587790725 1.1486265165851748 1.2395400688677265 1.2389869960155095 1.0 10.668082546731691 -7.519697587287444 24.57183413213861 1.1823747805215485 1.1082192345899629 0.06654529688605315 0.07906297760471477 202.54466002328394 1564541.4391169487 0.035366993984784635 0.020958600094753057 3.022055338737434e-08 7.519697587287444 -0.07415554593158569 SSDGS(ph)LSHEEDLAK ddPTM_A459_Selumetinib_30min_R1 1 SSDGSLSHEEDLAK 14 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YEF9;E9PJZ7 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 SSDGS(0.841)LS(0.159)HEEDLAK 246.86 2.7796999999999994e-27 4916500.0 971.98 1039.5 1262.9 1342.6 1006.8 967.34 1212.7 793.47 455.53 655.57 True False 994.6252428561519 917.7948567495608 1091.4051166131399 1108.140113723344 915.7351177649766 957.609437874446 1121.225062649629 772.4245980462 773.0011394051631 739.7187952925575 1.3445991222418234 1.2407348070513398 1.4754324529248861 1.4980559109425853 1.2379503178674878 1.2945587484980872 1.5157449963214555 1.0442138322856964 1.0449932384095264 1.0 9.530833123030735 -7.779518508019017 24.74071574266244 1.033452329103141 1.3679984900511386 0.73097794001369 0.09523843614172944 121.23569231973907 165904.5628290125 0.05386053237215321 0.025957677147677237 1.661427872368091e-08 7.779518508019017 0.3345461609479976 SSDGS(ph)LSHEEDLAK ddPTM_A459_Selumetinib_30min_R2 2 SSDGSLSHEEDLAK 14 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YEF9;E9PJZ7 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 S(0.186)S(0.186)DGS(0.589)LS(0.038)HEEDLAK;SS(0.003)DGS(0.995)LS(0.002)HEEDLAK 180.85 7.42e-05 8335500.0 71192.0 52939.0 70446.0 66865.0 73784.0 55118.0 59013.0 61824.0 49213.1 69191.0 True False 67235.43364415626 56999.251074285814 65913.58105580538 57757.87165144131 64514.59428267086 62710.00418861269 61757.221432041086 62003.89760448586 59057.095128903464 67193.2760501924 1.0006274079259414 0.8482880196480999 0.9809550141083891 0.859578146008196 0.9601346752981562 0.9332779687921336 0.9190982351553947 0.9227693788612099 0.8789137634067532 1.0 16.036029251029817 -9.300441485023565 18.907110864525286 0.9999999999993026 0.9216185078058472 0.19334776481349047 0.047371303470785546 0.0 0.0 0.041161725514586626 0.009983184825254243 5.006780071924524e-10 9.300441485023565 -0.07838149219345536 SSDGSLS(ph)HEEDLAK ddPTM_A459_Selumetinib_30min_R1 1 SSDGSLSHEEDLAK 14 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YEF9;E9PJZ7 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 SSDGS(0.091)LS(0.909)HEEDLAK 255.39 2.9991e-28 3870300.0 983.8 1073.9 1035.0 1426.9 1218.8 978.38 785.23 1040.0 537.43 669.36 True False 1006.7206258584356 948.1672887574349 894.452684848048 1177.718701230329 1108.5597551966173 968.5383854979643 725.9994689076998 1012.4158216039018 911.979457665833 755.2788761185318 1.3329124614633643 1.2553870083460823 1.184268106960368 1.559316351177152 1.4677489206286796 1.2823586308614887 0.9612336474160348 1.3404529818268285 1.2074738040505042 1.0 9.560865627465612 -7.0098354416337045 24.78117835807059 1.1508233144607236 1.3573988906945056 0.3821396848155115 0.13848778658822797 532.7169098836414 1342222.9234746553 0.052928847849030944 0.04402942584814875 9.776075757215954e-08 7.0098354416337045 0.20657557623378198 SSDITSDLGNVLTS(ph)TPNAK ddPTM_A459_Selumetinib_30min_R2 2 SSDITSDLGNVLTSTPNAK 19 0 Q5T8D3-4;Q5T8D3-2;B7Z2R7;Q5T8D3-3 Q5T8D3-4 ACBD5 Acyl-CoA-binding domain-containing protein 5 1 SSDITSDLGNVLT(0.001)S(0.958)T(0.041)PNAK;SSDITSDLGNVLTS(0.912)T(0.087)PNAK 249.89 1.1535e-37 5413200.0 76230.0 19871.4 60610.0 72758.0 39494.0 46311.0 104745.0 68110.0 70030.0 59425.0 True False 71993.4417728681 21395.472483378282 56710.418587178414 62848.234885449216 34532.41063916027 52689.919880598725 109615.85004828006 68308.18882378249 84037.95680168718 57709.24584530759 1.2475200588455095 0.37074600733355406 0.9826920757064375 1.0890496655235615 0.5983861014528947 0.913023885667066 1.8994503990246316 1.1836610897131783 1.4562303764453095 1.0 15.816514857286291 -7.035309752549004 23.524495854087377 1.4010118739656023 0.8409539635137244 0.3949609700145965 0.3140722499994622 278.92601083889224 185828.38335824327 0.11366461137293216 0.08809969129007589 9.219136546578986e-08 7.035309752549004 -0.5600579104518779 SSDPGPDIGVVEES(ph)PEKGDEISLR ddPTM_A459_Selumetinib_30min_R1 4 SSDPGPDIGVVEESPEKGDEISLR 24 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 SSDPGPDIGVVEES(1)PEKGDEISLR;SSDPGPDIGVVEES(1)PEKGDEISLR;SSDPGPDIGVVEES(0.999)PEKGDEIS(0.001)LR;SSDPGPDIGVVEES(1)PEKGDEISLR 111.81 1.6364e-07 29110900.0 5210.5 8514.5 6226.299999999999 7259.9 5562.200000000001 6549.8 6606.0 6711.0 4226.2699999999995 6992.3 True False 5331.894512131912 7517.618381716343 5380.802658617776 5992.094750201178 5059.099992086168 6483.91495874258 6107.704101478889 6533.00247959979 7171.671515452022 7889.829815769705 0.6757933487329283 0.9528238957310069 0.6819922335793555 0.7594707224513954 0.6412178855840909 0.8218066942056127 0.7741236812575079 0.8280283139367629 0.9089767058242152 1.0 12.945778466194477 -8.318860524536682 1.1486355729735775 0.9995171061235155 0.7562518124995531 0.49057340983140396 0.08236636480691334 0.39485872669610345 1.0787435353586763 0.07587748556075169 0.0247057801475731 4.7988754175399964e-09 8.318860524536682 -0.24326529362396243 SSDPGPDIGVVEES(ph)PEKGDEISLR ddPTM_A459_Selumetinib_30min_R2 2 SSDPGPDIGVVEESPEKGDEISLR 24 1 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 SSDPGPDIGVVEES(0.999)PEKGDEIS(0.001)LR;SSDPGPDIGVVEES(1)PEKGDEISLR 109.17 2.3884e-07 24292000.0 120054.0 96889.0 108098.0 104497.0 104724.0 86323.0 117996.0 101837.0 85613.0 100697.0 True False 113381.87929423997 104320.07475276235 101143.09236820333 90264.32833262032 91567.6348755613 98213.20968782637 123483.04780463838 102133.32880997699 102737.992227086 97789.61596777357 1.1594470248416233 1.0667806977291012 1.0342927658242864 0.9230461479914882 0.9363738058418931 1.0043316840531658 1.2627419239005095 1.0444189579764265 1.050602267023353 1.0 16.577393656719124 SSDQPLTVPVS(ph)PK ddPTM_A459_Selumetinib_30min_R1 4 SSDQPLTVPVSPK 13 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 SSDQPLTVPVS(1)PK;SSDQPLT(0.009)VPVS(0.991)PK;SSDQPLT(0.001)VPVS(0.999)PK;SSDQPLTVPVS(1)PK 195.23 0.00020038 176469400.0 26766.5 32541.5 36879.899999999994 37379.8 25443.600000000002 28681.4 26835.399999999998 26440.1 19950.1 27222.8 True False 27390.107371457405 28731.526051867066 31871.812146789878 30852.119635748426 23142.230872432432 28392.891156627597 24811.18417269551 25738.822658451278 33853.862602346584 30717.111552527156 0.8916888986980277 0.9353589774460179 1.037591444504414 1.0043952076350149 0.7533986661753187 0.924334669556248 0.8077316817457807 0.8379310865358268 1.1021173831548416 1.0 14.90675493985444 -3.985364944238412 15.015163700268173 0.9217884690966623 2.3182915477315547e-05 0.0 0.10409732261493959 386540.5310981082 13443.69516676282 0.024801765457346792 21248.34595826352 0.0001034272686390575 3.985364944238412 -0.921765286181185 SSDQPLTVPVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 SSDQPLTVPVSPK 13 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 SSDQPLT(0.009)VPVS(0.991)PK;SSDQPLTVPVS(1)PK;SSDQPLTVPVS(1)PK;SSDQPLT(0.001)VPVS(0.999)PK;SSDQPLTVPVS(1)PK;SSDQPLT(0.004)VPVS(0.996)PK 191.96 0.00010552 505312000.0 814038.0 825975.0 782363.0 751819.0 712306.0 589984.0 740773.0 671991.0 477603.0 731269.0 True False 768797.0268123056 889324.6265717745 732026.6163524287 649419.9552398842 622819.7521835641 671248.9406584864 775220.4123138528 673946.3825559011 573136.9453427981 710155.3639049593 1.0825758219791386 1.252295866191322 1.0307978416542616 0.9144758854863717 0.8770190071632221 0.9452142091379321 1.091620864554367 0.9490125919067139 0.8070585317996719 1.0 19.437775158511975 -5.487503218605735 4.623527678430981 0.9435086549282753 1.1657616753058935 0.5599604818105156 0.0798321663439323 0.1464771746081705 7.3729080308069745 0.022064578932463785 0.04539525199879526 3.2545937147273874e-06 5.487503218605735 0.22225302037761818 SSDTS(ph)GSPATPLK ddPTM_A459_Selumetinib_30min_R2 1 SSDTSGSPATPLK 13 0 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 S(0.009)S(0.001)DT(0.305)S(0.343)GS(0.343)PATPLK 76.868 0.044262 7495100.0 60499.0 46791.0 56998.0 56885.0 57302.0 38346.0 46275.0 44794.0 36297.0 39325.0 True False 57136.707776685726 50379.71924322159 53330.81073473013 49137.16486790156 50103.21047362038 43627.813429669804 48426.87919217294 44924.34312395412 43557.41422291645 38189.585071379406 1.4961332433932608 1.3192004874904464 1.396475259813652 1.2866640152298132 1.3119600639800995 1.142400823369144 1.2680650785196856 1.1763506474340297 1.1405574096053712 1.0 15.220891624759544 -1.5228787456619857 0.10012421235081334 0.8489300994385829 2.61159960144716 0.8527790275863889 0.0520002828872312 44.30779840577158 0.3155572530875668 0.6320473079264712 10.72784960214991 0.029999999973636685 1.5228787456619857 1.7626695020085772 SSDTSGS(ph)PATPLK ddPTM_A459_Selumetinib_30min_R1 2 SSDTSGSPATPLK 13 0 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 SSDT(0.005)S(0.029)GS(0.966)PATPLK;SSDT(0.001)S(0.003)GS(0.991)PAT(0.006)PLK 134.06 0.0012601 7838000.0 2928.3999999999996 3629.2 3609.1 4006.7 3801.3 2808.1000000000004 3595.1 3366.0 1776.4299999999998 2990.6 True False 2996.6260223255144 3204.2915768306916 3119.0040433672375 3307.0050600739764 3457.473086174025 2779.853063550801 3323.9187125683848 3276.722745691091 3014.47196468622 3374.4726409108457 0.8880279502034006 0.949568100799828 0.9242937712855033 0.9800064815998454 1.0245965678479396 0.8237888877357904 0.9850187173754014 0.9710325417860345 0.8933164631829839 1.0 11.72044634155458 SSDTSGSPAT(ph)PLK ddPTM_A459_Selumetinib_30min_R1 1 SSDTSGSPATPLK 13 0 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 SSDTS(0.001)GS(0.01)PAT(0.989)PLK 118.51 0.007972700000000001 5975900.0 2480.0 3226.5 2607.1 2808.8 2943.2 2571.5 2932.7 2569.5 1648.7 2876.1 True False 2537.779174760033 2848.739880040846 2253.0701397752127 2318.29580770604 2676.988079664163 2545.63304473519 2711.4840778696835 2501.3485130877184 2797.7234837163146 3245.2754505863977 0.7819919182211404 0.8778114287728949 0.6942616040090216 0.714360257859511 0.8248877854668547 0.7844120117061906 0.835517391098416 0.7707661648984966 0.8620912234771277 1.0 11.664125220307074 -9.093154602512119 0.6816350242146584 1.0051976634920243 0.7788930008964184 0.6144570618583047 0.05179872696664097 1.3712032053289611 1.0109846863579959 0.06648040187393027 0.02039991912603519 8.069477174742349e-10 9.093154602512119 -0.2263046625956059 SSDTSST(ph)SPLNSSASQEELHQDEGLVAAPIVSNSEKPIAK ddPTM_A459_Selumetinib_30min_R2 1 SSDTSSTSPLNSSASQEELHQDEGLVAAPIVSNSEKPIAK 40 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 S(0.007)S(0.007)DT(0.02)S(0.057)S(0.174)T(0.545)S(0.139)PLNS(0.018)S(0.018)AS(0.015)QEELHQDEGLVAAPIVSNSEKPIAK 62.401 1.1754e-05 5420600.0 26559.0 20125.0 24277.0 31048.0 26529.0 21914.0 24149.0 23927.0 21315.0 25756.0 True False 25082.957104100806 21668.522787925773 22715.044250799052 26819.208839212602 23196.189847730882 24932.45458451429 25271.976350335688 23996.623608671907 25578.595590860536 25012.35735787537 1.002822594656525 0.866312698075347 0.9081528752285722 1.0722383522466477 0.9273891907044639 0.9968054681045118 1.0103796291067533 0.9593907229666359 1.022638339316981 1.0 14.610353414207298 -5.711608161692947 24.999846521332216 0.9941874101018671 0.9198175279612263 0.3227883307911591 0.047713468574594554 121.17819256965292 60792.910156956255 0.01226968833556289 0.021251684647049178 1.9426378147105323e-06 5.711608161692947 -0.07436988214064078 SSDTSSTSPLNSS(ph)ASQEELHQDEGLVAAPIVSNSEKPIAK ddPTM_A459_Selumetinib_30min_R1 1 SSDTSSTSPLNSSASQEELHQDEGLVAAPIVSNSEKPIAK 40 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 S(0.014)S(0.014)DT(0.075)S(0.071)S(0.068)T(0.07)S(0.065)PLNS(0.082)S(0.271)AS(0.271)QEELHQDEGLVAAPIVSNSEKPIAK 48.265 0.002179 14808000.0 1692.3 1854.4 1825.5 2373.9 1622.3 1500.0 1534.4 1719.8 853.06 1438.6 True False 1731.7272973574209 1637.2859859128296 1577.6071267537313 1959.3429286219614 1475.5632514403287 1484.9113618910299 1418.6589726474735 1674.1853173022976 1447.5805149627217 1623.2583231506526 1.0668217576092487 1.008641670005394 0.9718768136002439 1.2070432048172022 0.9090132053512863 0.9147720610536596 0.873957615010984 1.0313733146630653 0.8917745834520349 1.0 10.6646768913704 SSDTSSTSPLNSS(ph)ASQEELHQDEGLVAAPIVSNSEKPIAK ddPTM_A459_Selumetinib_30min_R2 1 SSDTSSTSPLNSSASQEELHQDEGLVAAPIVSNSEKPIAK 40 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 1 SSDT(0.003)S(0.01)S(0.009)T(0.029)S(0.029)PLNS(0.103)S(0.408)AS(0.408)QEELHQDEGLVAAPIVSNSEKPIAK 55.117 4.8748e-05 7194800.0 20203.0 18818.0 25935.0 24384.0 25435.0 19033.0 19689.0 19779.0 19517.0 22391.0 True False 19080.19813901686 20261.280090593147 24266.37033589296 21062.857135253787 22239.627908214956 21654.62298562837 20604.577513013366 19836.55361541027 23420.945350543036 21744.51365119534 0.8774718278404899 0.9317881473738707 1.1159766884259097 0.968651563016031 1.0227696174291026 0.9958660530647451 0.9475759193115222 0.9122555663285583 1.0770967668552818 1.0 14.408363820664361 -5.0094955345031975 23.91965281504275 1.0005153381097802 0.891050793640875 0.3538672497421209 0.056129520638867295 272.5342109340543 686549.8406585201 0.014078867815595728 0.044778602523866326 9.783730145465525e-06 5.0094955345031975 -0.10946454446890519 SSDVSPPLGQHET(ph)GGSPSK ddPTM_A459_Selumetinib_30min_R2 1 SSDVSPPLGQHETGGSPSK 19 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 SSDVSPPLGQHET(0.416)GGS(0.416)PS(0.168)K 94.259 0.0025064 5661900.0 44946.0 32589.0 43616.0 53736.0 42907.0 36877.0 37848.0 47235.0 35707.0 52454.0 True False 42448.08125309368 35088.47150984909 40809.794045510214 46417.06410022959 37516.63906655317 41956.4720139241 39608.00699438923 47372.446029824765 42849.39773693906 50939.51672814076 0.8333035721488085 0.6888261562651418 0.8011421518446692 0.9112191689597869 0.7364938161226738 0.8236527299197145 0.7775497205003593 0.9299743906611225 0.8411818660475741 1.0 15.636497652133249 -9.062886822853166 0.32602988500541874 1.036013750944613 0.7719374275432368 0.47841480811086634 0.06367613682827977 2.745953701105677 0.5801811451148695 0.2206253378455516 0.07126054275054405 8.651933587985466e-10 9.062886822853166 -0.2640763234013762 SSDVSPPLGQHETGGS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 SSDVSPPLGQHETGGSPSK 19 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 SSDVSPPLGQHET(0.06)GGS(0.699)PS(0.241)K 91.416 0.0016383 8489500.0 33153.0 27519.0 32510.0 41377.0 37376.0 35150.0 33979.0 32773.0 25888.0 40807.0 True False 31310.488981974275 29629.61881246854 30418.341994211678 35741.38122069374 32680.49273432053 39991.59344006921 35559.09082811118 32868.36400413779 31066.323371156323 39628.79588068101 0.7900943817785313 0.7476790085088844 0.7675817878948116 0.901904295258126 0.8246652972429129 1.009154897375145 0.8973043474542255 0.829406073883791 0.7839330638431312 1.0 15.274261511292341 -5.756892799727761 24.788606074162054 0.8874847779934881 0.7663744127612144 0.4068823522863566 0.06835468948248327 107.46644197623594 585911.808686055 0.019095536712611477 0.03169297186483299 1.7502786701545421e-06 5.756892799727761 -0.1211103652322737 SSDYQFPS(ph)SPFTDTLK ddPTM_A459_Selumetinib_30min_R2 2 SSDYQFPSSPFTDTLK 16 0 Q9UK61-3;Q9UK61 Q9UK61-3 FAM208A Protein FAM208A 1 SSDYQFPS(0.662)S(0.275)PFT(0.063)DTLK;SSDYQFPS(0.495)S(0.495)PFT(0.009)DTLK 201.57 5.7803e-07 20992400.0 127253.0 104083.0 113129.0 129428.0 124955.0 108693.0 112339.0 121805.0 97017.0 108886.0 True False 120180.78769412028 112065.83142040657 105850.40330554203 111799.68312424628 109257.03578812664 123664.47413318463 117562.98609550562 122159.43238409687 116423.110881469 105742.17826019644 1.1365454133013528 1.0598025618939844 1.0010234803852753 1.0572856069707997 1.033239882001308 1.1694905114294825 1.1117889571578723 1.1552573854068242 1.1010091980041334 1.0 16.690191425701016 -6.742910556660753 24.998533628759287 1.1174802969505968 1.0545445775293676 0.16731012395447653 0.05321201458722326 343.98031193513225 464087.27376922057 0.017036143905699262 0.017005040947469185 1.8075463534769192e-07 6.742910556660753 -0.06293571942122922 SSDYQFPSS(ph)PFTDTLK ddPTM_A459_Selumetinib_30min_R1 4 SSDYQFPSSPFTDTLK 16 0 Q9UK61-3;Q9UK61 Q9UK61-3 FAM208A Protein FAM208A 1 SSDYQFPS(0.229)S(0.771)PFTDTLK;SSDYQFPS(0.203)S(0.763)PFT(0.03)DT(0.004)LK;SSDYQFPS(0.186)S(0.628)PFT(0.186)DTLK;SSDYQFPS(0.081)S(0.906)PFT(0.014)DTLK 189.04 8.5442e-07 65932100.0 17402.999999999996 20962.3 16709.600000000002 18496.399999999998 17844.3 15623.8 20032.0 19273.9 10100.800000000001 18238.600000000002 True False 17808.456039656787 18508.024170891127 14440.528099262749 15266.350960429361 16230.286215667044 15466.638757275385 18520.970112144274 18762.69356154946 17140.319866756672 20579.70196900841 0.8653408133157164 0.8993339261551463 0.7016879117593235 0.7418159399693648 0.7886550660504569 0.7515482381896036 0.8999629897476435 0.9117087113217073 0.8328750286359246 1.0 14.32893446912113 -7.276225288474097 22.792583384592778 0.9037791259333346 0.7898472109553413 0.43945515636838706 0.06602818605135784 275.0317390117533 423959.5252074277 0.02889073899590418 0.01960212956119458 5.293887544144283e-08 7.276225288474097 -0.11393191497799338 SSDYQFPSS(ph)PFTDTLK ddPTM_A459_Selumetinib_30min_R2 2 SSDYQFPSSPFTDTLK 16 0 Q9UK61-3;Q9UK61 Q9UK61-3 FAM208A Protein FAM208A 1 SSDY(0.002)QFPS(0.176)S(0.484)PFT(0.336)DT(0.002)LK;SSDYQFPS(0.19)S(0.801)PFT(0.01)DTLK 170.78 9.0826e-06 19376200.0 76748.0 62441.0 72066.0 66275.0 71548.0 65311.0 65799.0 67758.0 49342.5 68780.0 True False 72482.6534065864 67230.02392054025 67429.35201952825 57248.23066924804 62559.50059276444 74306.99741577121 68858.78387824501 67955.16456205917 59212.378744641595 66794.14268809871 1.0851648137030623 1.006525740355362 1.0095099556018812 0.8570845940275607 0.9366015952160908 1.1124777476784822 1.0309105126146663 1.0173820911121199 0.8864905867740402 1.0 16.02743397498329 -4.733943281681852 2.18254376393292 0.9828781364135062 1.1198369203289578 0.16781324352745985 0.06964707449983946 1.5891464070002927 7.864306748538455 0.019822206049355744 0.44916184584294533 1.8452563916290924e-05 4.733943281681852 0.13695878391545158 SSDYQFPSSPFT(ph)DTLK ddPTM_A459_Selumetinib_30min_R2 1 SSDYQFPSSPFTDTLK 16 0 Q9UK61-3;Q9UK61 Q9UK61-3 FAM208A Protein FAM208A 1 SSDYQFPS(0.007)S(0.036)PFT(0.725)DT(0.231)LK 114.06 0.004437 0.0 6642.1 6881.9 6763.7 9136.6 7545.0 5133.9 6422.3 6995.9 5473.3 6170.3 True False 6272.958672433003 7409.719601203788 6328.53090575975 7892.179318485882 6597.12964684419 5841.048124095914 6720.94967554602 7016.256910766407 6568.112936779584 5992.147406635282 1.0468632105890403 1.236571649255288 1.0561373871997841 1.3170869778247842 1.1009625096236773 0.9747837841285327 1.1216262250330682 1.1709085966405128 1.0961200536399551 1.0 12.548857399147327 -6.501918220614398 24.99313955141485 1.0810331619942393 1.167546011844459 0.18293727760445866 0.09050500966758916 1396.8765412866542 1665625.2081276055 0.027613572908660167 0.03097858597517897 3.148341103492157e-07 6.501918220614398 0.08651284985021968 SSEAS(ph)PTAQR ddPTM_A459_Selumetinib_30min_R2 2 SSEASPTAQR 10 0 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 SS(0.001)EAS(0.5)PT(0.5)AQR;S(0.089)S(0.348)EAS(0.498)PT(0.064)AQR 125.97 0.0035357 57283000.0 35109.0 30798.0 30010.0 36532.0 39725.0 32655.0 39710.0 40929.0 36774.0 35804.0 True False 33157.782332462666 33160.107568821746 28079.189272417472 31556.27857878494 34734.390353994066 37152.929837424184 41556.59368387223 41048.096613839305 44129.82755141004 34770.245490036104 0.9536252006608492 0.9536920749761238 0.8075637337810558 0.907565596217255 0.9989687983062324 1.0685265322061321 1.1951768846665418 1.180552395743142 1.269183663487681 1.0 15.085565632580115 -6.780891133355913 1.7169842612514448 1.176225267165263 0.9033235174277005 0.6956606646536834 0.07534039092088506 0.1880870042200988 1.1471890344840572 0.03164043092281032 0.028431671808006046 1.656185075154752e-07 6.780891133355913 -0.27290174973756265 SSEGGVGVGPGGGDEPPT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 3 SSEGGVGVGPGGGDEPPTSPR 21 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 SSEGGVGVGPGGGDEPPT(0.947)S(0.053)PR;SSEGGVGVGPGGGDEPPT(0.899)S(0.101)PR;SSEGGVGVGPGGGDEPPT(0.889)S(0.111)PR 267.22 2.0763e-59 30834000.0 4419.4800000000005 5186.57 4441.12 4849.83 5057.9800000000005 4002.33 5490.5599999999995 4892.39 2266.9700000000003 3126.11 True False 4522.4452851889 4579.323973229023 3838.040297325952 4002.8982330842287 4600.486602058897 3962.070194024884 5076.402638724783 4762.627924477611 3846.8825170621512 3527.3766693900216 1.282098768876575 1.2982236949537094 1.088072144557687 1.134808841885445 1.3042232325175653 1.1232342234406265 1.4391439062283728 1.3501897786553079 1.090578885562392 1.0 11.784379926217468 -8.475412442306776 5.336664481870356 1.0005725556766996 1.247658745602512 0.4016317042075074 0.10390219243563842 0.18510791250631217 12.054628529058562 0.10559027608176068 0.027431949536564495 3.3464747900939458e-09 8.475412442306776 0.24708618992581255 SSEGGVGVGPGGGDEPPTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SSEGGVGVGPGGGDEPPTSPR 21 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 SSEGGVGVGPGGGDEPPT(0.23)S(0.77)PR;SSEGGVGVGPGGGDEPPT(0.188)S(0.812)PR;SSEGGVGVGPGGGDEPPT(0.235)S(0.765)PR;SSEGGVGVGPGGGDEPPT(0.243)S(0.757)PR 179.84 2.9786e-14 49478700.0 191942.0 181412.0 219767.0 216788.0 231222.0 168322.0 186009.0 199834.0 184113.0 238778.0 True False 181274.63204470504 195325.7170684819 205627.4304842175 187261.1004198409 202173.82520909279 191506.8276250167 194658.787069841 200415.4838557005 220940.74454703747 231883.85872025008 0.781747522424141 0.8423428786568851 0.8867690559362783 0.807564189475374 0.8718753703896218 0.8258739037806632 0.8394667405663702 0.8642925167874072 0.9528077795772123 1.0 17.82304287288246 -8.326518578227052 2.066333847488385 0.9996227027635471 0.8383043999267231 0.8014912858546871 0.027942039846549253 0.1278566883343105 1.0465742449806719 0.02571794697047452 0.007363366791484235 4.71499701115021e-09 8.326518578227052 -0.16131830283682402 SSEKPTGLWSTAS(ph)SQRVSPGLPSPNLENGAPAVGPVQPR ddPTM_A459_Selumetinib_30min_R1 1 SSEKPTGLWSTASSQRVSPGLPSPNLENGAPAVGPVQPR 39 2 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 SSEKPT(0.001)GLWS(0.082)T(0.082)AS(0.274)S(0.274)QRVS(0.274)PGLPS(0.011)PNLENGAPAVGPVQPR 54.745 8.8278e-05 24662000.0 836.72 658.47 1441.8 1472.5 1123.1 718.58 618.47 601.65 561.72 704.27 True False 856.2139480262954 581.3760262856023 1246.0114792404972 1215.3555172483423 1021.5158032994098 711.3517376184371 571.8183099669465 585.6922875653723 953.1978135944246 794.6699146707283 1.0774460341575507 0.7315943583022085 1.56796105683299 1.5293840811274768 1.2854592635769722 0.8951537292225111 0.7195670798785424 0.7370258729475799 1.1994889903305102 1.0 9.634211916389214 -6.767010793774789 23.386602342162192 0.8818935614949709 1.2446930270553742 0.29251776493880277 0.25313697448617883 80.63389040130187 338464.9580644911 0.0955123148895847 0.08673929154194134 1.7099728156075632e-07 6.767010793774789 0.3627994655604033 SSELDASDS(ph)SSSSNLSLAK ddPTM_A459_Selumetinib_30min_R2 2 SSELDASDSSSSSNLSLAK 19 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 SSELDASDS(0.332)S(0.332)S(0.332)S(0.003)S(0.001)NLSLAK;SSELDASDS(0.303)S(0.303)S(0.303)S(0.076)S(0.014)NLSLAK 164.82 1.7227e-07 7573000.0 71463.0 47528.0 57251.0 58255.0 55612.0 54009.0 53945.0 66163.0 44815.0 55864.0 True False 67491.3725490552 51173.24477339305 53567.53299017569 50320.568504519775 48625.52338241206 61448.249505112326 56453.54938998959 66355.52337612571 53779.25223572196 54251.061167896776 1.244056265372988 0.943267166978016 0.9874006487061019 0.9275499395078582 0.8963054792960686 1.13266447111406 1.040598067110181 1.223119362970024 0.9913032312729394 1.0 15.727363736953373 -6.7822087804254 24.996103991824942 1.0891733014474854 0.99188641598861 0.10633925786594545 0.10907407190275198 458.8898668017527 552273.1611417412 0.037745137009147625 0.0333228903756977 1.651167833735835e-07 6.7822087804254 -0.09728688545887532 SSEMS(ph)PVPMR ddPTM_A459_Selumetinib_30min_R1 2 SSEMSPVPMR 10 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RE77 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 S(0.007)S(0.001)EMS(0.992)PVPMR;S(0.231)S(0.026)EMS(0.743)PVPMR 117.14 0.0061178000000000005 28164400.0 6043.1 6991.9 7791.599999999999 7492.2 7386.0 6073.700000000001 7064.4 6594.7 3587.2000000000003 5658.7 True False 6183.892472174334 6173.285097553876 6733.543516195217 6183.827916012243 6717.937604104212 6012.604092478365 6531.526620418928 6419.787133395431 6087.216401278071 6385.049265405669 0.9684956552612356 0.9668343721325479 1.054579727783417 0.9684855447422078 1.052135594395824 0.94166917788008 1.0229406773424408 1.0054405011685614 0.9533546490014945 1.0 12.64048203609866 SSEMS(ph)PVPMR ddPTM_A459_Selumetinib_30min_R2 4 SSEMSPVPMR 10 0 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4;B7Z7Y1;Q8TEU7-2;Q8TEU7-5;Q8TEU7-3;D6RE77 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 S(0.009)S(0.039)EMS(0.952)PVPMR;S(0.121)S(0.01)EMS(0.869)PVPMR;S(0.099)S(0.006)EMS(0.895)PVPMR;S(0.022)S(0.075)EMS(0.903)PVPMR 147.28 0.00083069 89569000.0 295069.0 237910.0 290968.0 320568.0 353905.0 238679.0 250965.0 269339.0 201341.0 260508.0 True False 278670.24623479537 256156.93199877898 272247.43566200486 276906.08538935496 309444.28994915733 271554.8657377608 262635.36977771344 270122.73189852835 241614.8259375762 252986.4571589302 1.1015223872625333 1.0125321919420258 1.0761344252153964 1.094549046217909 1.2231654351156016 1.0733968481449805 1.0381400361392532 1.0677359370617727 0.9550504349163239 1.0 17.948700631243355 -7.907225672078124 1.4871969747845444 0.9820320372858996 1.094909916548826 0.3950568125948918 0.053439548515531086 0.4741263699502277 1.9017459557324854 0.049350462380365764 0.017380387254481763 1.2381530389145258e-08 7.907225672078124 0.11287787926292647 SSEPVKETVQTTQS(ph)PTPVEK ddPTM_A459_Selumetinib_30min_R1 2 SSEPVKETVQTTQSPTPVEK 20 1 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 SSEPVKETVQTTQS(0.96)PT(0.039)PVEK;SSEPVKETVQTTQS(0.627)PT(0.373)PVEK 172.8 5.4176e-10 211451000.0 13182.5 13676.5 15303.5 15777.300000000001 12988.599999999999 11740.9 13683.3 12447.7 7243.1 9407.9 True False 13489.626601320202 12075.24902196764 13225.368756108317 13022.090731600862 11813.783423323577 11622.797205884259 12651.157664511973 12117.546560172012 12291.011684906664 10615.49560570626 1.2707486397591252 1.1375115652138468 1.245855045053115 1.226705866149194 1.1128810054778024 1.0948897383214526 1.191763261407358 1.1414960742537859 1.1578368209487784 1.0 13.373884107477018 -14.522878745257662 0.09091556075621308 0.4555605838162932 1.3095470277950336 0.5903952806160715 0.04872694861160325 160.75427226550764 1.009841229737887 17.02538413047487 1.1556746709087025 3.0000000001566357e-15 14.522878745257662 0.8539864439787404 SSEPVKETVQTTQS(ph)PTPVEK ddPTM_A459_Selumetinib_30min_R2 2 SSEPVKETVQTTQSPTPVEK 20 1 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 SSEPVKETVQTT(0.001)QS(0.968)PT(0.031)PVEK;SSEPVKET(0.002)VQT(0.008)T(0.05)QS(0.593)PT(0.346)PVEK 146.17 1.3615e-05 29182000.0 143359.0 125377.0 138534.0 138207.0 138393.0 90827.0 98054.0 109622.0 86705.0 126374.0 True False 135391.68069154667 134993.0127494049 129620.87326441487 119382.96817962675 121006.83409088243 103337.59480458501 102613.70529031503 109940.98187110107 104048.4227401155 122725.25426091556 1.1032096165284948 1.0999611576473731 1.0561874493153554 0.9727661099468324 0.9859978275833942 0.8420238803081872 0.8361254242925168 0.8958301413445439 0.8478159068948199 1.0 16.90507263010457 -6.025102173817026 1.1222088176691383 0.8773654345792916 1.1072899246609362 0.7421903368133553 0.05016092818519977 0.23753935600016632 0.6100961896620485 0.019350467756719534 0.0377145518242243 9.438387989592129e-07 6.025102173817026 0.22992449008164462 SSEPVKETVQTTQSPT(ph)PVEK ddPTM_A459_Selumetinib_30min_R1 2 SSEPVKETVQTTQSPTPVEK 20 1 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 SSEPVKETVQTTQS(0.072)PT(0.928)PVEK;SSEPVKETVQTTQS(0.337)PT(0.663)PVEK 177.69 5.3189e-13 231997000.0 23395.9 25018.2 27871.3 28783.7 26039.6 23214.0 24891.5 24571.8 14015.6 18734.7 True False 23940.978949503307 22089.05751335437 24086.530546092166 23757.167131966777 23684.32277766476 22980.488236625577 23013.914114738378 23920.076043544952 23783.44954107743 21139.481236431617 1.1325244305543134 1.0449195638389774 1.1394097270741739 1.1238292400015881 1.1203833487099666 1.087088560953955 1.0886697671216443 1.13153562171248 1.125072525435923 1.0 14.367652352920446 -11.337689799949308 10.546502442536832 0.9987823658886864 1.1092980642829955 0.5908247969757435 0.027544396002137095 0.0007910739042376896 1.3890655788784424e-05 0.026753168912556337 0.006422696353815073 4.59526117696155e-12 11.337689799949308 0.11051569839430908 SSEPVKETVQTTQSPT(ph)PVEK ddPTM_A459_Selumetinib_30min_R2 3 SSEPVKETVQTTQSPTPVEK 20 1 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 SSEPVKETVQTTQS(0.33)PT(0.67)PVEK;SSEPVKETVQTTQS(0.462)PT(0.538)PVEK;SSEPVKETVQTT(0.001)QS(0.006)PT(0.993)PVEK 180.31 3.5433e-13 395169000.0 185085.0 173004.0 173601.0 184936.0 187651.0 126322.0 129698.0 134877.0 110204.0 165396.0 True False 174798.71665395904 186272.8505044623 162431.70066247776 159747.39776760575 164076.60375877525 143721.70886305632 135729.2139917114 135269.46973991048 132247.87935703454 160620.58772958376 1.0882709316706347 1.1597071903264726 1.0112757209925238 0.9945636485688367 1.0215166441490673 0.8947900819851443 0.845029992171497 0.8421676925229927 0.8233557181329911 1.0 17.29329729824945 -6.198312717395692 0.8256329932284892 0.861291400187684 1.1221435252348235 0.6899181021527117 0.059694784388322195 0.3573010600423018 0.5171113272546597 0.030979502715120396 0.05666564181100964 6.334134523244401e-07 6.198312717395692 0.2608521250471395 SSEPVQADESQS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SSEPVQADESQSPR 14 0 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 1 SSEPVQADESQS(1)PR;SSEPVQADESQS(1)PR 312.38 4.2888999999999975e-94 12950500.0 2236.98 2904.7 2436.0 2895.3999999999996 2746.9 2115.2 3098.5 2863.4 1092.53 2289.64 True False 2289.0972815946343 2564.6163736416056 2105.204579990188 2389.7727433893706 2498.4433800045836 2093.9230084479373 2864.777650383337 2787.4533303659737 1853.943614765927 2583.537596982245 0.8860321151387394 0.9926762345697077 0.8148534716309979 0.925000180442814 0.9670629074347292 0.8104867569544132 1.108858510025014 1.0789288817092955 0.7175988524151785 1.0 11.335132163425891 -7.2461994022196325 24.882477571390254 0.9829239862840572 0.9039967279923561 0.10019033741252126 0.11183084538843997 1837.6042604769723 3000280.0715406383 0.04221407659017025 0.03258146334686251 5.672840824630364e-08 7.2461994022196325 -0.07892725829170111 SSEPVQADESQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SSEPVQADESQSPR 14 0 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 1 SSEPVQADESQS(1)PR;SSEPVQADES(0.002)QS(0.998)PR 238.12 2.0982e-19 24755100.0 43557.0 36780.0 39899.0 41789.0 46623.0 25849.2 29946.2 34242.0 27271.4 31110.7 True False 41136.27631248615 39600.90773366008 37331.94177874659 36097.26610995409 40765.80192509166 29409.69266432537 31338.757637269577 34341.63855093175 32726.442026581928 30212.45325569393 1.3615668997264725 1.3107478362816094 1.2356474816129306 1.1947810329884778 1.3493045923838978 0.9734294800698692 1.0372794745280534 1.1366716320681314 1.083210348713215 1.0 14.882855715423444 -6.759228401292473 24.99999909893868 1.0541077358366209 1.2831844504844048 0.7932526625114139 0.06223664480511067 29.448570333848995 332982.6731127284 0.022315697599792857 0.021290497278820663 1.7408910746335885e-07 6.759228401292473 0.2290767146477839 SSESPSS(ph)SPSSPAR ddPTM_A459_Selumetinib_30min_R1 1 SSESPSSSPSSPAR 14 0 Q9Y3R5-2;Q9Y3R5 Q9Y3R5-2 DOPEY2 Protein dopey-2 1 S(0.002)SES(0.21)PS(0.21)S(0.439)S(0.136)PS(0.002)S(0.002)PAR 101.45 0.012368 0.0 315.99 279.8 206.47 335.78 359.69 262.17 363.81 208.73 175.45 0.0 True False 323.35195219049274 247.0408859245089 178.432508058528 277.142326371238 327.15610300842746 259.53280783131424 336.36751879488844 203.1938023494062 297.7258356390047 0.0 0.0 SSESPSSSPSS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 1 SSESPSSSPSSPAR 14 0 Q9Y3R5-2;Q9Y3R5 Q9Y3R5-2 DOPEY2 Protein dopey-2 1 SSESPSSSPS(0.002)S(0.998)PAR 136.17 0.00086158 0.0 6373.1 4365.4 7015.0 8872.5 10351.0 5496.8 6076.2 6690.3 6292.3 6897.8 True False 6018.908615540679 4700.2121430266425 6563.662537354506 7664.050194083795 9050.614840885912 6253.934305017709 6358.7553397618885 6709.76766536121 7550.935821551567 6698.6425913632775 0.8985266094508467 0.7016663568656044 0.9798496408536851 1.1441198854175683 1.3511117689060004 0.9336121788436748 0.9492602796811979 1.0016607952799685 1.1272337221405382 1.0 12.709653063051558 -5.4639372164133855 5.09547380225114 1.072871188729409 0.803790843212168 0.4355996915745636 0.1225671882430291 0.20095181109397744 10.759747828267555 0.03484522116902878 0.07297071914007172 3.4360761779039204e-06 5.4639372164133855 -0.2690803455172409 SSETGAFRVPS(ph)PGMEEAGCSR ddPTM_A459_Selumetinib_30min_R1 2 SSETGAFRVPSPGMEEAGCSR 21 1 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 S(0.087)S(0.087)ET(0.264)GAFRVPS(0.553)PGMEEAGCS(0.009)R;S(0.011)S(0.011)ET(0.111)GAFRVPS(0.865)PGMEEAGCS(0.002)R 81.726 0.00094324 55217000.0 3061.1 2644.2 6129.0 6127.5 4514.8 3298.7 2987.2 2402.1 1868.58 1923.81 True False 3132.417674136263 2334.615834744769 5296.7154641871375 5057.447152420522 4106.43713715268 3265.518072979961 2761.873098991484 2338.388504879549 3170.84378431651 2170.749752996285 1.4430118763402313 1.0754882415728941 2.4400396484560614 2.329815836873748 1.891713741523898 1.5043272806884198 1.2723129854923494 1.07722619876007 1.4607136451080072 1.0 11.083977704341317 -7.014948747235751 2.7106065564939423 1.2087514751857948 1.8528418184327182 0.37550676722933607 0.38445746657433344 0.34306119372947463 5.067551509699698 0.17528021875784455 0.1392937793688902 9.661648931017314e-08 7.014948747235751 0.6440903432469234 SSFASSSASDASKPS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 SSFASSSASDASKPSSPR 18 1 Q96IF1 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 SSFAS(0.006)S(0.007)S(0.037)AS(0.037)DAS(0.125)KPS(0.738)S(0.05)PR 113.07 0.0056552 12884000.0 1937.3 2551.0 2925.7 3689.7 2853.5 2773.3 2872.3 2862.6 1419.5 2150.8 True False 1982.4353206704077 2252.3277340722757 2528.4060097197416 3045.3631592469987 2595.401428826344 2745.4031199549304 2655.6400984980028 2786.674548964739 2408.7878238219837 2426.876130566122 0.816867122183101 0.9280769239536222 1.0418356247666978 1.254849030360936 1.0694412442965968 1.13124979284151 1.0942627293789884 1.1482557819358858 0.9925466707936517 1.0 11.244884758878975 -5.15849791701254 2.369434229271621 1.1063182843784762 0.8280244273920767 0.6115346862763995 0.0725751052696489 0.20139975368193586 2.0485393559405614 0.019033271997345915 0.08098498518568167 6.942279314009278e-06 5.15849791701254 -0.2782938569863995 SSFASSSASDASKPSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 SSFASSSASDASKPSSPR 18 1 Q96IF1 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 SSFASSSASDAS(0.002)KPS(0.077)S(0.921)PR;SSFASSSASDAS(0.001)KPS(0.025)S(0.973)PR;SSFASSSASDASKPS(0.025)S(0.975)PR 316.32 1.0824e-111 33213100.0 5941.1 6457.9 7271.400000000001 7561.8 6201.799999999999 5454.4 6323.8 6307.6 3354.6000000000004 4538.3 True False 6079.516070631784 5701.806065803737 6283.983818941151 6241.273582566055 5640.848285016717 5399.533688198955 5846.790674679411 6140.301958027666 5692.511189709918 5120.835011785491 1.1872118622529158 1.1134524062347555 1.2271404574602967 1.218799974652942 1.101548531056835 1.0544244592477683 1.1417650951891924 1.1990821699773366 1.1116372967706882 1.0 12.322163362297353 -6.273985091719175 24.605470665690216 1.1110322151901366 1.1843147834381251 0.342468227190727 0.05689757462354547 865.2185968534602 1696920.131043244 0.01820173039174146 0.020787540906721046 5.321265255719116e-07 6.273985091719175 0.07328256824798851 SSFASSSASDASKPSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SSFASSSASDASKPSSPR 18 1 Q96IF1 Q96IF1 AJUBA LIM domain-containing protein ajuba 1 SSFASSSASDAS(0.005)KPS(0.143)S(0.852)PR;SSFASSSASDASKPS(0.006)S(0.994)PR;SSFASS(0.001)S(0.001)ASDAS(0.006)KPS(0.23)S(0.762)PR;SSFASSSASDAS(0.003)KPS(0.011)S(0.986)PR 297.87 8.292399999999996e-95 136447900.0 399503.0 376873.0 393100.0 401852.0 388809.0 244412.0 277427.0 271530.0 212290.0 377718.0 True False 377300.22259722097 405777.9472623082 367808.3739749183 347119.0643666333 339963.3374234385 278077.53444876836 290327.9052111716 272320.1073457889 254753.93187819785 366812.2999107775 1.0285920692653832 1.1062277556150888 1.0027154870880368 0.946312499474706 0.9268046287055541 0.7580921755252135 0.7914890129959934 0.7423963357063745 0.6945076049526244 1.0 18.48468249047656 -6.2580666563629155 1.1816000407560108 0.7780310140473279 1.0620495732223543 0.6215627054345836 0.08286749027135633 0.27638387980004747 0.7945655847879309 0.032811560098034015 0.048334495622889204 5.519927118623801e-07 6.2580666563629155 0.2840185591750264 SSFDWLTGSSTDPLVDHT(ph)SPSSDSLLFAHK ddPTM_A459_Selumetinib_30min_R1 2 SSFDWLTGSSTDPLVDHTSPSSDSLLFAHK 30 0 P78527-2;P78527 P78527-2 PRKDC DNA-dependent protein kinase catalytic subunit 1 SSFDWLTGSSTDPLVDHT(0.834)S(0.166)PSSDSLLFAHK;SSFDWLTGSSTDPLVDHT(0.494)S(0.494)PS(0.009)S(0.003)DS(0.001)LLFAHK 113.68 1.3302e-11 41937000.0 6983.75 12297.2 8531.9 9515.1 10408.5 9982.800000000001 10753.6 8982.3 2482.8900000000003 6430.53 True False 7146.457786988053 10857.438107186816 7373.314842372039 7853.4664055481835 9467.053012769931 9882.382095657184 9942.447294226973 8744.060225377625 4213.282986889304 7255.951164166523 0.9849098519682433 1.4963493912150645 1.0161748164437925 1.0823482997422151 1.3047294281035025 1.3619692128664365 1.3702472727941855 1.2050880756419808 0.5806658412609749 1.0 12.824949030570988 -8.188034582044155 7.7899931263395565 0.7923021981955933 1.237667896681556 0.4806229986491095 0.1817202079420749 0.2173742293233387 20.670698191522458 0.12054943204858794 0.045048035396914925 6.485827860774398e-09 8.188034582044155 0.44536569848596264 SSFFSDRGS(ph)GSR ddPTM_A459_Selumetinib_30min_R1 4 SSFFSDRGSGSR 12 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8YDH3;A0A2R8YF89;A0A2R8Y650;A0A2R8YCU0;A0A087WX09;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 SSFFS(0.059)DRGS(0.905)GS(0.036)R;SSFFS(0.001)DRGS(0.972)GS(0.027)R;SSFFS(0.004)DRGS(0.951)GS(0.046)R;SSFFS(0.017)DRGS(0.959)GS(0.024)R 98.654 0.0082965 47115500.0 10197.699999999999 8195.800000000001 11553.4 12521.600000000002 11501.400000000001 7821.299999999999 9393.4 10888.8 5163.1 7980.1 True False 10435.286568729989 7236.231925875949 9984.511738283518 10334.937619542847 10461.100400737096 7742.624823172207 8684.848275330276 10599.993652192852 8761.403602096016 9004.423567756508 1.158906674059313 0.8036307789637763 1.1088451873850713 1.1477622683755915 1.1617734685645762 0.8598690149247739 0.9645090782301065 1.1771984705550549 0.9730110468669299 1.0 13.136418207372525 -10.936719002456421 0.4639403715117309 0.9790316537823956 1.039021329414478 0.009740601657400982 0.12745643557513184 293.7901146660397 31.493795238869268 7.473848832635449 0.06798104776266271 1.1568605128551421e-11 10.936719002456421 0.05998967563208224 SSFFSDRGS(ph)GSR ddPTM_A459_Selumetinib_30min_R2 2 SSFFSDRGSGSR 12 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8YDH3;A0A2R8YF89;A0A2R8Y650;A0A2R8YCU0;A0A087WX09;A0A2R8Y5G6;A0A2R8YCW1;A0A2R8YFR4;A0A2R8YFS5;A0A2R8Y4A4 A0A2R8Y645;A0A2R8Y5G6 DDX3X ATP-dependent RNA helicase DDX3X 1 SSFFSDRGS(0.965)GS(0.035)R;SSFFS(0.009)DRGS(0.963)GS(0.028)R 77.633 0.025012 60766000.0 104045.0 71097.0 91025.0 109772.0 89666.0 55117.0 63668.0 70878.0 57980.0 73857.0 True False 98262.59542513541 76549.91128711354 85168.55060052671 94820.86423273777 78401.35545578947 62708.866447689754 66628.68815574866 71084.24324551536 69577.62009655598 71724.55650646826 1.3699993448725458 1.0672761884586923 1.18743920839505 1.3220139496322525 1.0930894420897406 0.8743012087085481 0.9289522501228705 0.991072607595766 0.9700669266638315 1.0 16.130179521973197 -6.534197175486701 5.215819914876305 0.9523459511484609 1.220559822801926 0.7228702363630917 0.08257854056338904 0.09729165763540848 7.985769387386112 0.027055083581783653 0.02813467987187731 2.9228250749955765e-07 6.534197175486701 0.2682138716534652 SSFLSS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 SSFLSSPER 9 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 SSFLS(0.083)S(0.917)PER;SSFLS(0.076)S(0.924)PER 120.31 0.006621300000000001 39075000.0 9592.0 10187.900000000001 10282.099999999999 11743.0 10997.900000000001 8828.0 10096.6 9420.8 4593.799999999999 7263.200000000001 True False 9815.474937217023 8995.095931773783 8885.847295532474 9692.305493410719 10003.141886836951 8739.198335182675 9335.005333180707 9170.929780928882 7795.3430821228785 8195.502469559167 1.1976660337392337 1.0975649101668352 1.0842345943445784 1.1826371268157354 1.220564806610938 1.0663407603918094 1.1390400244346255 1.119019830082753 0.9511732942644316 1.0 13.00061668891281 -8.2064405138136 5.328907054687103 0.9755235291383562 1.1380047635574049 0.6447319266260022 0.0484180131859582 0.12135856734579348 7.5169054214618365 0.036215916486032285 0.012705364511687328 6.216693932250018e-09 8.2064405138136 0.16248123441904871 SSFLSS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 SSFLSSPER 9 0 Q4AC94 Q4AC94 C2CD3 C2 domain-containing protein 3 1 SSFLS(0.182)S(0.818)PER;SSFLS(0.025)S(0.975)PER 114.97 0.0083159 33057000.0 225106.0 215741.0 250864.0 259333.0 289360.0 185187.0 198165.0 206549.0 176763.0 228313.0 True False 212595.50969071547 232287.64098334883 234723.68336007124 224011.39802562178 253008.00988877876 210694.8282897892 207380.065156498 207150.02339397251 212120.53917087853 221721.0104615857 0.9588424175414296 1.047657326203616 1.0586442974953802 1.0103300429637583 1.1411097638516927 0.9502700165904807 0.9353198631233355 0.9342823350963498 0.9567002185732393 1.0 17.758385962064274 -6.908633908774019 24.999893676758845 0.949897525314453 1.0428899770878455 0.47713379150412705 0.045885818156451194 15.037222828516548 4108.771956334202 0.01570968466590798 0.013854640355857593 1.2341447248228175e-07 6.908633908774019 0.09299245177339244 SSFSQHAR ddPTM_A459_Selumetinib_30min_R2 2 SSFSQHAR 8 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 136.27 0.0036604 1320830.0 4337.6 2101.63 7115.299999999999 7595.8 10060.8 11234.7 12188.3 31445.0 19813.8 29722.0 False True 4096.533556788575 2262.8182631944555 6657.509344552887 6561.238936514138 8796.872359306828 12782.177946547532 12755.080100658268 31536.49974400003 23777.11364382791 28863.848632969843 0.1419261030945573 0.07839627667010915 0.2306521707901531 0.22731684259941473 0.3047712892056455 0.44284385319104813 0.44190503708811474 1.0925951055597396 0.8237679578415059 1.0 14.816976057532115 -7.424135202772191 0.9877453498139191 1.0207154413965924 0.16664171651416734 0.8850081268740895 0.11741851528237575 0.16543742479930904 0.3032023883316223 0.08994028311661777 0.04526851367414973 3.765865433590154e-08 7.424135202772191 -0.8540737248824251 down SSFTPSS(ph)PENVIGDFLLQDR ddPTM_A459_Selumetinib_30min_R2 1 SSFTPSSPENVIGDFLLQDR 20 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 SSFTPS(0.025)S(0.975)PENVIGDFLLQDR 202.96 5.9168e-16 12804000.0 26987.0 27103.0 26289.0 35690.0 30825.0 26350.0 24321.0 21964.0 16093.0 36057.0 True False 25487.170577520552 29181.712950119356 24597.594361299012 30828.96043131594 26952.487921003605 29979.473318515615 25451.974691147225 22027.911603664044 19312.049675989594 35015.94072266314 0.7278733642881872 0.8333836632077763 0.7024684716061012 0.8804264513551313 0.7697205148499502 0.8561664401925434 0.7268682253244194 0.6290823878796169 0.5515216577771501 1.0 15.095724226350027 -7.511188230468734 22.557378419233906 0.6897762610133122 0.7949646265622936 0.046071719126841826 0.1205223211845116 300.2010463228983 579263.2294164902 0.04979999456884771 0.03142789638681781 3.081851934737413e-08 7.511188230468734 0.10518836554898137 SSFVSDNSLNRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 SSFVSDNSLNRSPR 14 1 Q6UB98-2;Q6UB98 Q6UB98-2 ANKRD12 Ankyrin repeat domain-containing protein 12 1 SSFVSDNSLNRS(1)PR;SSFVSDNSLNRS(0.999)PR;SSFVSDNSLNRS(1)PR 162.88 0.0012927 21349000.0 7883.4 8837.2 9956.1 11451.3 9047.5 8500.5 8338.1 7331.0 4555.9 6937.400000000001 True False 8067.067881573883 7802.536515697183 8604.116304942656 9451.545422523553 8229.155222465863 8414.992687836462 7709.150403957176 7136.558065555964 7731.029550229366 7827.882865998426 1.0305555179695385 0.9967620427214952 1.0991626282907114 1.2074203950569762 1.0512619265434366 1.075002377001352 0.9848321105369395 0.9116843197225991 0.9876271378318962 1.0 12.93440645274899 -7.310675269072481 3.6318639899565004 0.9600386032674955 1.0796815908411779 0.45898531641449436 0.056200848232737355 0.22682967841745555 6.177957393643623 0.026987341818610847 0.0180214050598668 4.8901787140812185e-08 7.310675269072481 0.11964298757368241 SSFYSGGWQEGSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SSFYSGGWQEGSSSPR 16 0 D3DPQ1;Q96BR9-2;Q96BR9 D3DPQ1 ZBTB8A Zinc finger and BTB domain-containing protein 8A 1 SSFYSGGWQEGS(0.002)S(0.09)S(0.908)PR 176.49 1.2075e-06 5474800.0 1285.6 1503.4 1253.2 1289.1 1121.7 1166.0 1148.3 1173.4 746.3 910.73 True False 1315.5519786578607 1327.3812290883022 1083.022323334854 1063.9828844039641 1020.2424330522194 1154.2710986432944 1061.682806498366 1142.2776202596333 1266.4165924046126 1027.63106676143 1.2801792600566377 1.291690444189793 1.0539018898562391 1.0353743856315054 0.9928100327557284 1.1232349195912978 1.0331361524951264 1.1115639232857282 1.232365031932825 1.0 10.005106695413572 -5.259262585731885 24.984205120872517 1.0729742263195632 1.2859348753489241 0.6197077060791094 0.06678555032155752 119.58032132856079 1372464.2896268372 0.017640098264907766 0.04224416869406059 5.50474764415444e-06 5.259262585731885 0.21296064902936096 SSFYSGGWQEGSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SSFYSGGWQEGSSSPR 16 0 D3DPQ1;Q96BR9-2;Q96BR9 D3DPQ1 ZBTB8A Zinc finger and BTB domain-containing protein 8A 1 SSFYSGGWQEGS(0.001)S(0.075)S(0.924)PR 138.77 0.00040382 6628000.0 36114.0 31496.0 43964.0 43766.0 38873.0 34647.0 40829.0 37949.0 28324.0 34692.0 True False 34106.928455796406 33911.64192439799 41135.404104383924 37804.995299438866 33989.42621097071 39419.309755848604 42727.62940112866 38059.42530720483 33989.59143868324 33690.351819359064 1.012364864536617 1.0065683524537066 1.2209846998613652 1.1221312113967137 1.0088771525217435 1.1700474357527362 1.2682452718281385 1.1296832253718176 1.0088820568253083 1.0 15.040047873767339 -5.2204173070593844 24.100086614163896 1.1244834870900184 1.0094664325591962 0.19174758898452016 0.08621486919913837 519.0852005596097 304955.03764115693 0.022452625688212147 0.05940257891197311 6.019808736805331e-06 5.2204173070593844 -0.11501705453082223 SSFYVNGLTLGGQK ddPTM_A459_Selumetinib_30min_R2 2 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 0 ; 198.52 0.0012823 21919600.0 161000.0 122702.0 136297.0 167948.0 179938.0 147266.0 139494.0 152246.0 108536.0 141889.0 False True 152052.26453406483 132112.84885088558 127527.79940895305 145073.19267353998 157332.57977387006 167550.55475235375 145980.74740211727 152689.01065431774 130246.23274922092 137792.29589810464 1.103488867378371 0.9587825501404017 0.9255074717911513 1.0528396506348907 1.1418096980560886 1.2159646057153652 1.0594260473754489 1.1081099248627733 0.9452359574989306 1.0 17.07213570224455 -4.424480168754352 21.58525589883549 1.0526163567310618 7.871326152280478 0.0322341253671381 0.08776362769397308 2182.2048972044836 479740.9354252792 0.023197516329751387 1593.1658034349562 3.7628753434229434e-05 4.424480168754352 6.818709795549416 SSGAPQDSDSS(ph)ATCSADEVDEAEGGDKNR ddPTM_A459_Selumetinib_30min_R2 1 SSGAPQDSDSSATCSADEVDEAEGGDKNR 29 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SSGAPQDS(0.004)DS(0.031)S(0.434)AT(0.147)CS(0.385)ADEVDEAEGGDKNR 136.37 3.9707999999999996e-14 67707000.0 73639.0 78276.0 73483.0 76305.0 79373.0 61678.0 59744.0 52222.0 44524.0 68749.0 True False 69546.4391802734 84279.51750299032 68755.18378224102 65912.12736653314 69401.45413637695 70173.58464286182 62522.21438049012 52373.95737418251 53430.044104502624 66764.03773864612 1.0416751523105785 1.2623490183878652 1.0298236312697178 0.9872399812688403 1.0395035484231083 1.0510686144771932 0.9364654460420594 0.78446359968828 0.8002817971204704 1.0 16.02678358783548 -7.386322848530201 2.6147236700379963 0.8447625744890855 1.073181134059203 0.5292861963072805 0.08831978027211018 0.2194339840955502 2.914266173712152 0.045076918527445824 0.027479752714861132 4.108441916476642e-08 7.386322848530201 0.22841855957011747 SSGAPQDSDSSAT(ph)CSADEVDEAEGGDKNR ddPTM_A459_Selumetinib_30min_R1 1 SSGAPQDSDSSATCSADEVDEAEGGDKNR 29 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SSGAPQDSDS(0.003)S(0.233)AT(0.382)CS(0.382)ADEVDEAEGGDKNR 157.61 1.4643999999999999e-18 38214000.0 2679.3 3015.4 3016.3 3587.9 2692.4 2683.4 2384.1 2449.2 1541.2 2374.8 True False 2741.72247698974 2662.3555661785704 2606.7030273499213 2961.34061822433 2448.8728953818277 2656.4074323322584 2204.265417550078 2384.239259877189 2615.303835205665 2679.628712510891 1.0231725254282207 0.9935539031016968 0.9727851530995739 1.1051309475817142 0.9138851528005765 0.9913341426481157 0.8226010593402756 0.889764782988568 0.975994854434534 1.0 11.387817400372175 -6.301787722828209 24.987965105711105 0.924221976742377 1.017876230937124 0.3593362195967146 0.05900336004815531 555.5439178283908 344050.153564393 0.018335707258799735 0.020790960331057012 4.991283949429501e-07 6.301787722828209 0.09365425419474704 SSGAPQDSDSSATCS(ph)ADEVDEAEGGDKNR ddPTM_A459_Selumetinib_30min_R1 2 SSGAPQDSDSSATCSADEVDEAEGGDKNR 29 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SSGAPQDSDSSAT(0.002)CS(0.997)ADEVDEAEGGDKNR;SSGAPQDSDSS(0.003)AT(0.002)CS(0.995)ADEVDEAEGGDKNR 177.38 4.796499999999999e-28 32454000.0 3550.56 4041.7999999999997 4616.7 5598.1 4418.1 3776.8999999999996 3613.7999999999997 3693.9300000000003 2397.77 3467.7700000000004 True False 3633.281139812893 3568.584177018159 3989.7774977178583 4620.496924351745 4018.4836350789096 3738.907815150819 3341.2081565129297 3595.9549768243296 4068.840563808128 3912.892058440244 0.9285411111650216 0.9120068030807543 1.0196492615000123 1.1808393524133058 1.0269855582678038 0.9555356394475194 0.8538973492268532 0.9190018337121593 1.0398550491653604 1.0 11.934019597072812 -6.8264827017751415 5.690582205613448 0.9412742294614354 1.0175093663625454 0.10949990591091496 0.08197341180830847 0.4270968008656262 26.10668794219005 0.032152865055251986 0.02857996179400364 1.4911361471690624e-07 6.8264827017751415 0.07623513690111006 SSGAPQDSDSSATCS(ph)ADEVDEAEGGDKNR ddPTM_A459_Selumetinib_30min_R2 2 SSGAPQDSDSSATCSADEVDEAEGGDKNR 29 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 SSGAPQDS(0.001)DS(0.001)S(0.012)AT(0.024)CS(0.962)ADEVDEAEGGDKNR;SSGAPQDS(0.001)DS(0.004)S(0.013)AT(0.01)CS(0.972)ADEVDEAEGGDKNR 134.0 8.1577e-14 43724200.0 89236.0 88308.0 99346.0 111698.0 96565.0 67530.7 82213.5 86815.0 58344.3 96417.0 True False 84276.62036001128 95080.93964502617 92954.18651974652 96484.5397102025 84433.64139794692 76832.44094234091 86036.59065295973 87067.61727700308 70014.79027594849 93633.19068854881 0.9000720763680883 1.0154619205629016 0.9927482534365313 1.0304523321344254 0.9017490569001085 0.8205684370824009 0.9188685125463941 0.9298798496210096 0.7477561082889722 1.0 16.514732400318664 -6.399712312084938 5.676009414059054 0.8792856763411725 0.9868997994730659 0.3182325901824664 0.07057490851135388 0.2608340871142924 11.031955178144896 0.021289771210514827 0.02412250021570985 3.9837097442171237e-07 6.399712312084938 0.10761412313189345 SSGDPEQIKEDSLS(ph)EESADAR ddPTM_A459_Selumetinib_30min_R1 3 SSGDPEQIKEDSLSEESADAR 21 1 Q9BVS4-2;Q9BVS4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 SSGDPEQIKEDS(0.089)LS(0.76)EES(0.151)ADAR;SSGDPEQIKEDS(0.284)LS(0.712)EES(0.004)ADAR;SSGDPEQIKEDS(0.335)LS(0.543)EES(0.122)ADAR 128.51 3.2467e-05 50681500.0 6088.0 7431.3 9017.7 8519.3 6494.5 6562.290000000001 6954.4 5824.09 4591.86 6156.67 True False 6229.838554814142 6561.239941282356 7793.145870680431 7031.564182067091 5907.073621697103 6496.279320682591 6429.824008980435 5669.616213889491 7792.051043814882 6946.938565544229 0.8967746721862785 0.9444793385427531 1.1218101034221408 1.0121817136749405 0.8503132086118192 0.9351283676097496 0.9255622384328249 0.8161316183232042 1.121652504955533 1.0 12.762161623741111 -4.83489849424983 5.013196094265767 0.9645437975416206 0.896648172704998 0.050464689187665 0.09515226005743223 0.6688574288758005 28.337410852780522 0.024315659752242196 0.11855177189595252 1.4625189626746635e-05 4.83489849424983 -0.06789562483662259 SSGEIVYCGQVFEKS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 2 SSGEIVYCGQVFEKSPLR 18 1 M0R0P7;M0R3D6;M0R1A7;M0R117;Q02543 M0R0P7 RPL18A 60S ribosomal protein L18a 1 SSGEIVYCGQVFEKS(1)PLR;SSGEIVYCGQVFEKS(1)PLR 105.38 0.00095459 572430000.0 9585.5 10668.9 10914.3 11403.5 9892.3 9120.5 10078.7 9737.8 5093.9 9233.1 True False 9808.823499863825 9419.78022816295 9432.198007958503 9412.092795206432 8997.543211627415 9028.756050751424 9318.455544592078 9479.521911167765 8643.976256264043 10418.25832301007 0.9415031952317569 0.9041607470375492 0.9053526717730039 0.9034228662211811 0.8636321861740727 0.8666281609480012 0.8944350634895532 0.909895072406778 0.8296949440361546 1.0 13.346826494135534 -4.054451715369878 0.9619871030221455 0.8898006424086888 1.0836026682830207 0.08070256078769611 0.042070578702044725 15.056445871941165 4.057162951903706 0.012797276806991916 4.244575582303931 8.821618749740363e-05 4.054451715369878 0.19380202587433182 SSGEIVYCGQVFEKS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 4 SSGEIVYCGQVFEKSPLR 18 1 M0R0P7;M0R3D6;M0R1A7;M0R117;Q02543 M0R0P7 RPL18A 60S ribosomal protein L18a 1 SSGEIVYCGQVFEKS(1)PLR;SSGEIVYCGQVFEKS(1)PLR;SSGEIVYCGQVFEKS(1)PLR;SSGEIVY(0.002)CGQVFEKS(0.998)PLR 88.071 0.0036519 107273800.0 320885.3 344615.3 401181.7 374277.7 430951.0 275059.6 295016.3 284837.3 265110.6 385331.4 True False 303051.7796316319 371046.1853971619 375370.10619560856 323300.4315949552 376811.08262917865 312946.56315755507 308735.1425137083 285666.12938564667 318140.1278090728 374205.8812707874 0.8098530643144379 0.9915562634587803 1.0031111882070574 0.8639640576920934 1.0069619465881832 0.8362951487956355 0.8250408611036706 0.76339294405405 0.8501740451771691 1.0 18.513472707557256 -6.790192235185285 24.52392864921327 0.8383213402176206 0.9380539438054493 0.18161550191084797 0.08114385763648509 232.07380775933638 197938.85203229726 0.027435230129856648 0.02420021163982502 1.6210923816444666e-07 6.790192235185285 0.09973260358782865 SSGFGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SSGFGSPR 8 0 A1L390-3;A1L390;G3V311;A1L390-2;A0A0U1RR71 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 SS(0.001)GFGS(0.998)PR 81.525 0.043521 47088000.0 225010.0 182870.0 206440.0 259410.0 266590.0 175790.0 181550.0 189660.0 182900.0 213130.0 True False 212504.84498639734 196895.54098027217 193157.87515487758 224077.91049279034 233098.58085516133 200003.47683726216 189992.4347345003 190211.87920009682 219485.1106529856 206976.38312175655 1.0267105926833624 0.9512947226662368 0.9332363057153721 1.0826255010987105 1.1262085912383446 0.9663106187318363 0.9179425781285142 0.9190028172837584 1.060435530578726 1.0 17.659106633963702 -9.834072713997003 12.921791201597891 1.0000002579693166 0.995527144389334 0.0 0.06958079403387121 0.0 0.0 0.0730467679204401 0.017716443514467897 1.4653024845788805e-10 9.834072713997003 -0.0044731135799825905 SSGGREDLES(ph)SGLQR ddPTM_A459_Selumetinib_30min_R2 1 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 SSGGREDLES(0.5)S(0.5)GLQR 78.166 0.018421 25592000.0 44280.0 34699.0 36575.0 46353.0 32258.0 41880.0 28535.0 38981.0 21788.0 37858.0 True False 41819.09486688443 37360.30172512975 34221.80431984905 40039.64143661498 28205.46164982103 47648.58985121192 29861.934041029814 39094.42825634804 26146.208807584764 36764.94117310316 1.1374721006619979 1.0161937033769048 0.9308271202915825 1.0890712771195064 0.7671836469700609 1.2960333494582366 0.8122394076581982 1.0633616431555482 0.7111723281285448 1.0 15.166043056047771 SSGGREDLESS(ph)GLQR ddPTM_A459_Selumetinib_30min_R1 2 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 SSGGREDLES(0.028)S(0.972)GLQR;SSGGREDLES(0.037)S(0.963)GLQR 204.67 2.6901e-05 11539000.0 5318.6 7360.5 7231.6 7493.5 7034.8 6589.9 6891.0 6144.7 4357.3 5139.200000000001 True False 5442.513031805932 6498.729238196383 6249.588440335402 6184.900895416264 6398.503582094812 6523.611589150467 6371.206322024074 5981.72259520144 7394.01985539946 5798.866380047151 0.9385477565981919 1.1206895990149615 1.0777258917086112 1.0665706864185365 1.1034059353584873 1.1249804981878928 1.0986985911498566 1.0315330968451806 1.2750802261698841 1.0 12.501555180120821 -4.756950511061025 24.97766908761232 1.099967763291019 0.9385475126293064 0.32780569488650246 0.06929629601273934 151.79778624809802 844550.2048120594 0.015949570544081984 0.12316469454640845 1.7500460993789188e-05 4.756950511061025 -0.16142025066171262 SSGGREDLESS(ph)GLQR ddPTM_A459_Selumetinib_30min_R2 3 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 1 SSGGREDLES(0.005)S(0.995)GLQR;SSGGREDLES(0.096)S(0.904)GLQR;SSGGREDLES(0.156)S(0.844)GLQR 166.3 0.00038214 179722000.0 308395.0 261627.0 312591.0 347940.0 309116.0 235860.0 188231.0 199030.0 160068.0 260914.0 True False 291255.6405029997 281692.9496366035 292479.2353833475 300549.97177002084 270282.0845478975 268347.5740760944 196984.1144726504 199609.1443488098 192086.07267360404 253380.7348840151 1.1494782373108272 1.1117378350234413 1.1543073135265383 1.186159523562821 1.066703372975925 1.0590685759867668 0.7774234081482941 0.7877834297077904 0.758092649630728 1.0 17.95094731168635 -7.1201741904354705 2.8942157785051053 0.8117924111211977 1.1347929981427853 0.8024127432737659 0.07085285751439213 0.10728039253774836 1.7277342247619398 0.028765613498400275 0.021540243694464133 7.582733794478767e-08 7.1201741904354705 0.3230005870215876 SSGGREDLESSGLQR ddPTM_A459_Selumetinib_30min_R2 1 SSGGREDLESSGLQR 15 1 Q9UK76;Q9UK76-3;J3KT51;Q9UK76-2;J3KSH8 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 115.09 0.006803399999999999 5478500.0 17049.0 15826.0 15842.0 21647.0 17525.0 12491.0 8121.2 15406.0 10502.0 12864.0 False True 16101.484832554486 17039.803311389467 14822.742967465432 18698.64125684215 15323.352824512187 14211.521867991592 8498.851891852513 15450.828909399399 12602.693450397242 12492.582895314043 1.2888835693533112 1.3639936155861798 1.1865234829080407 1.496779442132499 1.2265960492653576 1.1375967633820803 0.680311826871321 1.2368001908712563 1.0088140743996585 1.0 13.608784170748061 -6.812400716493471 3.044510699965582 0.9937077624334061 1.3250595367456335 0.5237369910826151 0.1482826372139839 0.20441660232680103 3.863032414832513 0.05393364925719389 0.04868966034888486 1.5402786069376101e-07 6.812400716493471 0.3313517743122274 SSGGSGGGPLSHFYS(ph)GSPTSYFTSGLQAGLK ddPTM_A459_Selumetinib_30min_R1 1 SSGGSGGGPLSHFYSGSPTSYFTSGLQAGLK 31 0 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 SSGGSGGGPLS(0.003)HFY(0.135)S(0.641)GS(0.155)PT(0.05)S(0.011)Y(0.003)FT(0.001)SGLQAGLK 80.117 1.0231e-05 15512000.0 1721.7 2027.1 1759.9 2237.3 2138.1 1550.0 2037.9 1657.1 393.73 1320.5 True False 1761.812260154978 1789.7661896267778 1520.9152464387232 1846.5975543223872 1944.709232512215 1534.408407287398 1884.1795622772975 1613.1483249806017 668.1310530985769 1489.9990377592362 1.18242509928363 1.2011861378906339 1.0207491467417193 1.2393280180230375 1.3051748244326409 1.0298049652400767 1.2645508584427392 1.082650581712164 0.4484103923337821 1.0 10.541095683657963 -8.08692860635127 6.89885937651396 0.7288577895928454 1.1741295249718224 0.5843692341311306 0.15072639262724596 0.16340242547190167 10.999555745401087 0.09477200036528917 0.035436462452599585 8.185993465811774e-09 8.08692860635127 0.445271735378977 SSGGSGGGPLSHFYSGS(ph)PTSYFTSGLQAGLK ddPTM_A459_Selumetinib_30min_R1 1 SSGGSGGGPLSHFYSGSPTSYFTSGLQAGLK 31 0 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 SSGGSGGGPLS(0.001)HFY(0.049)S(0.214)GS(0.721)PT(0.008)S(0.003)Y(0.002)FT(0.001)S(0.001)GLQAGLK 87.352 7.053399999999998e-07 14613000.0 691.85 838.83 890.62 749.88 1151.1 654.19 1011.8 647.16 264.04 446.05 True False 707.9687588942452 740.6193936385129 769.6786958254767 618.9275349909589 1046.9832082432117 647.6094425569951 935.4791113951464 629.9952145280586 448.0565952814068 503.3048623949314 1.4066400144148 1.4715124946624625 1.5292494734961015 1.2297269135168838 2.080216756224518 1.286714059298778 1.8586729064045842 1.2517169246692401 0.8902290217292347 1.0 8.975288725458077 -8.002832165280429 5.6872307821633425 0.9778264843525049 1.5474646981997542 0.5038648819502889 0.24181682581227934 0.12638873948564247 14.879637987739965 0.14265732457767383 0.060153863018614494 9.934999159843325e-09 8.002832165280429 0.5696382138472493 SSGHS(ph)SSELS(ph)PDAVEK ddPTM_A459_Selumetinib_30min_R2 1 SSGHSSSELSPDAVEK 16 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.109)S(0.05)GHS(0.781)S(0.06)S(0.001)ELS(0.999)PDAVEK 156.17 0.0015595999999999993 9964400.0 60396.0 47055.0 95312.0 152950.0 151850.0 94009.0 72708.0 75248.0 89313.0 119120.0 True False 57039.43210434404 50663.96719432781 89179.72968785932 132117.94614653336 132773.24544377584 106957.88642126508 76089.06606816873 75466.95922202301 107178.09561372394 115680.69608907112 0.49307649446045143 0.4379638859997685 0.7709128031110156 1.1420915555764464 1.147756280283306 0.9245958058456901 0.6577507625782449 0.6523729695049156 0.9264994008265615 1.0 16.819788613038597 -5.384103291459165 4.006537259796433 0.9084754839272376 0.4667023421792897 0.5583908036413343 0.15939087290425388 0.19234109629259732 5.229225167998924 0.04940762522758512 0.11090471591595638 4.1294927553833045e-06 5.384103291459165 -0.44177314174794796 SSGHSS(ph)SELS(ph)PDAVEK ddPTM_A459_Selumetinib_30min_R1 1 SSGHSSSELSPDAVEK 16 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.057)S(0.003)GHS(0.152)S(0.538)S(0.251)ELS(1)PDAVEK 154.81 0.0018736 6330700.0 2463.3 2978.3 2505.6 2638.0 4696.0 2636.4 3780.8 2975.9 586.19 1421.5 True False 2520.6900972525764 2629.5992514258955 2165.3532822756206 2177.3228213929533 4271.247629146138 2609.8802096596746 3495.611212060456 2896.9694649144735 994.7216163763358 1603.9633715825464 1.5715384415328286 1.6394384672459248 1.3500017024323818 1.3574641790259232 2.6629333966223445 1.6271445195688246 2.1793585028138893 1.8061319330853458 0.6201647955307709 1.0 10.647425481168396 -8.255451655812568 24.72587795001896 0.8100823520225149 1.7799458376181916 0.5042807043262882 0.38234639290871947 315.295547448957 1302006.3309075793 0.2831193276318087 0.10066061149729028 5.553264307321695e-09 8.255451655812568 0.9698634855956767 SSGHSS(ph)SELS(ph)PDAVEK ddPTM_A459_Selumetinib_30min_R2 1 SSGHSSSELSPDAVEK 16 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.1)S(0.047)GHS(0.385)S(0.468)SELS(1)PDAVEK 183.75 1.5549e-05 11570000.0 55054.0 43298.0 84126.0 125790.0 124460.0 79554.0 67358.0 70430.0 72861.0 100530.0 True False 51994.319078623696 46618.81737498679 78713.42474946333 108657.18500014638 108824.22211348279 90511.84138069034 70490.28046734488 70634.93963968582 87435.23590643612 97627.4376916918 0.5325789584155856 0.4775175757680887 0.8062633477900027 1.1129779452297683 1.1146889100700412 0.9271147898660153 0.7220334993319576 0.7235152464284836 0.8956010520583084 1.0 16.574999046382125 -5.365289015019735 4.0523060531711765 0.9179798277828752 0.5046665854721264 0.6266709597665299 0.12816673858592995 0.1633886628654683 4.643003301237801 0.039748937498722804 0.08989986587114752 4.312320043205924e-06 5.365289015019735 -0.41331324231074884 SSGHSSSELS(ph)PDAVEK ddPTM_A459_Selumetinib_30min_R1 6 SSGHSSSELSPDAVEK 16 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSGHSS(0.007)S(0.002)ELS(0.99)PDAVEK;SSGHS(0.047)S(0.047)S(0.016)ELS(0.889)PDAVEK;SSGHS(0.002)S(0.048)S(0.018)ELS(0.932)PDAVEK;SSGHS(0.002)S(0.026)S(0.003)ELS(0.969)PDAVEK;SSGHSSSELS(1)PDAVEK;SSGHSSSELS(1)PDAVEK 272.24 1.3040999999999995e-110 58014300.0 11741.0 11834.800000000001 10583.9 12429.3 19883.899999999998 11449.000000000002 17181.8 10697.1 2816.5099999999998 6083.300000000001 True False 12014.54245599094 10449.176114150749 9146.664513201213 10258.756081857264 18085.40475578766 11333.833454860274 15885.762992853468 10413.37815892221 4779.4117602485785 6864.150811359906 1.750331947268311 1.522282420843342 1.3325267414089788 1.4945411841592142 2.6347621508922865 1.6511632343658906 2.314308561892775 1.5170672156107745 0.6962859487788112 1.0 12.744865535111852 -8.11558825017972 4.480271009456227 0.8656534676928103 1.8044202896112718 0.5021612433842775 0.3785020579626689 0.19901850617267022 6.236930643609291 0.2897184353908547 0.1026748348261613 7.663228048270749e-09 8.11558825017972 0.9387668219184615 SSGHSSSELS(ph)PDAVEK ddPTM_A459_Selumetinib_30min_R2 4 SSGHSSSELSPDAVEK 16 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSGHSSSELS(1)PDAVEK;SSGHSSS(0.004)ELS(0.996)PDAVEK;SSGHSS(0.001)S(0.009)ELS(0.99)PDAVEK;SSGHSS(0.008)SELS(0.992)PDAVEK 303.44 1.0133999999999992e-196 42029500.0 55337.0 55700.0 148154.0 263217.0 338032.0 162536.0 91515.0 125764.0 184498.0 231879.0 True False 52261.59107156247 59972.010896271575 138621.93293787903 227366.39052534796 295565.39811557747 184923.85864509502 95770.62883353222 126129.95241864902 221402.75530483582 225184.05077600465 0.2320838926711918 0.2663244163589854 0.615593921772769 1.0096913602087838 1.3125503209353964 0.8212120619015008 0.42529934293080685 0.5601193867149727 0.9832079782820402 1.0 17.780745122986346 -5.406967704027011 3.1256444687859357 0.8511583515840038 0.24268482230034744 0.5256342108898606 0.23458581239097162 0.2327457167866037 4.253859579311704 0.07301957894157046 0.174215214350924 3.917710097724544e-06 5.406967704027011 -0.6084735292836563 SSGLS(ph)TPVPPSAGHLAHVR ddPTM_A459_Selumetinib_30min_R2 1 SSGLSTPVPPSAGHLAHVR 19 0 Q63ZY3-3;Q63ZY3;Q63ZY3-2 Q63ZY3-3 KANK2 KN motif and ankyrin repeat domain-containing protein 2 1 S(0.223)S(0.223)GLS(0.277)T(0.277)PVPPSAGHLAHVR 83.751 0.0028815 3185100.0 7120.9 8568.1 17734.0 18589.0 17726.0 7686.3 5177.1 6000.0 6323.1 18059.0 True False 6725.148885221262 9225.24571921624 16593.01374731927 16057.146132186375 15499.10140754938 8745.018055715624 5417.845408229036 6017.459006646528 7587.8966821754675 17537.58974708306 0.38347053285014965 0.5260269998476061 0.9461399192599487 0.9155845451828454 0.8837646239345557 0.49864423685530324 0.30892759417696836 0.34311778832934453 0.43266473851901593 1.0 14.09816286627932 -6.873594271009497 6.975281975410299 0.45825528332156223 0.7410276125031128 0.14168846529002788 0.24434272562060658 0.3468534196971041 19.97235110270803 0.08885212955631423 0.07841169471699634 1.3378447816518515e-07 6.873594271009497 0.28277232918155054 SSGNS(ph)PTPVSR ddPTM_A459_Selumetinib_30min_R1 3 SSGNSPTPVSR 11 0 O95429;O95429-2;H0YBT1 O95429 BAG4 BAG family molecular chaperone regulator 4 1 S(0.051)S(0.028)GNS(0.905)PT(0.015)PVSR;S(0.012)S(0.006)GNS(0.981)PT(0.001)PVSR;S(0.002)S(0.007)GNS(0.991)PTPVSR 183.28 3.1732e-05 89179200.0 10470.7 12864.6 12494.5 14102.3 12991.2 10523.900000000001 12055.3 11233.8 6354.8 9984.900000000001 True False 10714.646937564457 11358.406651409716 10797.81552737578 11639.598037956732 11816.14825378265 10418.039120936673 11145.959015222294 10935.843131474921 10783.631463771715 11266.559176162207 0.9510132392713575 1.008152220550338 0.9583951371969718 1.0331102740385725 1.048780561041499 0.9246868505318968 0.9892957415787529 0.9706462248574511 0.9571361846292636 1.0 13.459759361126508 -9.46710739021341 12.25577124637071 1.000000433680036 0.9840210679671684 0.01871516861851863 0.03658157271751132 0.0 0.0 0.03579701355232446 0.008682051056347097 3.4110855353929825e-10 9.46710739021341 -0.015979365712867732 SSGNS(ph)PTPVSR ddPTM_A459_Selumetinib_30min_R2 2 SSGNSPTPVSR 11 0 O95429;O95429-2;H0YBT1 O95429 BAG4 BAG family molecular chaperone regulator 4 1 S(0.048)S(0.101)GNS(0.825)PT(0.026)PVSR;SSGNS(0.955)PT(0.044)PVSR 122.52 0.0041278 33778000.0 67446.0 62678.0 73775.0 79680.0 85732.0 52385.0 59549.0 62507.0 53557.0 66644.0 True False 63697.62132773008 67485.20105846503 69028.39682014652 68827.44654433317 74961.5797061956 59600.5582463165 62318.146494104956 62688.88502140912 64269.89650761046 64719.81455809302 0.9842058689855266 1.0427285912244042 1.0665728462214006 1.0634679195898051 1.1582477517593857 0.920901251854153 0.9628913018310288 0.9686196638455922 0.993048217867208 1.0 15.981919853564206 -6.781797027318705 24.999999058579142 0.9667432704329437 1.0621355030290944 0.5289157003737578 0.04430184210353082 200.25489424480784 245919.2959297097 0.016042419006826177 0.014164367272529262 1.65273404262933e-07 6.781797027318705 0.0953922325961507 SSGNS(ph)SSSGSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNS(0.2)S(0.2)S(0.2)S(0.2)GS(0.2)GS(0.002)GSTSAGSSSPGAR 261.88 1.8532999999999997e-62 2635400.0 79.007 253.87 265.91 208.3 476.92 306.45 193.52 313.97 171.21 238.21 True False 80.84770937913946 224.14678237903902 229.80088253907672 171.9243152752663 433.782670207065 303.36739123433733 178.92263059615414 305.6424956817089 290.5308653163522 268.78657386189127 0.3007877522211391 0.8339210517792113 0.854956701286552 0.6396313357660676 1.613855424303866 1.1286553002837652 0.66566803551761 1.1371196533006707 1.080897982150082 1.0 8.070317265738757 -4.742252470301622 0.9609016513802917 1.0583005827381928 6.015918076362191e-13 0.4179961988894928 0.257858411057934 2.3648079545347853 1.6442542725668456 0.0906226604580391 2.6636728176147577 1.8102874044104627e-05 4.742252470301622 -1.0583005827375913 SSGNS(ph)SSSGSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 S(0.001)SGNS(0.569)S(0.233)S(0.011)S(0.184)GS(0.002)GSGSTSAGSSSPGAR 140.45 2.1888e-08 441120.0 0.0 0.0 601.64 1121.6 479.04 0.0 601.16 0.0 827.45 0.0 True False 0.0 0.0 562.9311374161027 968.83614513208 418.8587125280638 0.0 629.1151311759417 0.0 992.9631208847076 0.0 0.0 SSGNSS(ph)SSGSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 S(0.003)S(0.003)GNS(0.19)S(0.595)S(0.19)S(0.02)GSGSGSTSAGSSSPGAR 166.91 3.3805999999999997e-16 506380.0 71.874 0.0 123.49 53.312 63.841 0.0 74.449 72.637 61.038 0.0 True False 73.54852435754133 0.0 106.72073628201493 44.0020599901824 58.066592822044 0.0 68.83325199076624 70.71043080177176 103.5770279608639 0.0 0.0 SSGNSS(ph)SSGSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R2 3 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 S(0.002)S(0.002)GNS(0.051)S(0.372)S(0.051)S(0.051)GS(0.372)GS(0.023)GS(0.023)T(0.01)S(0.005)AGS(0.002)S(0.016)S(0.023)PGAR;S(0.001)S(0.003)GNS(0.078)S(0.513)S(0.4)S(0.004)GSGSGSTSAGSSSPGAR;S(0.001)S(0.001)GNS(0.181)S(0.754)S(0.008)S(0.021)GS(0.021)GS(0.007)GS(0.002)T(0.002)S(0.001)AGSSSPGAR 164.06 1.1016e-13 25219540.0 21538.399999999998 7556.200000000001 20192.899999999998 24432.76 13593.2 12276.04 23737.5 22046.52 18241.22 16673.29 True False 20341.381953046606 8135.7362429875575 18893.71079836718 21104.975939138105 11885.500691250156 13966.953079204195 24841.34078496393 22110.671723202144 21889.973702271498 16191.88879529001 1.2562698651292383 0.502457517207883 1.1668626827441586 1.3034289085086381 0.7340404100791181 0.8625894888351126 1.5341842510794617 1.3655399936808994 1.351909834548702 1.0 13.982983666404133 -7.252991887788176 24.935956490531673 1.3433701889629657 0.962897090888422 0.29126545490852185 0.25941292293137114 716.4640010229834 2114917.0558392894 0.09945682423690827 0.07577259155983679 5.584806265314268e-08 7.252991887788176 -0.38047309807454366 SSGNSSSS(ph)GSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSS(0.001)S(0.051)S(0.698)GS(0.245)GS(0.004)GSTSAGSSSPGAR 162.2 1.844e-13 928140.0 2368.1 755.29 999.73 2468.8 958.37 435.89 2640.6 2169.6 775.44 917.46 True False 2236.4904822554004 813.2183143598734 935.4084602237225 2132.5451810824543 837.9709926634938 495.92989088454516 2763.3931322496346 2175.913176803386 930.5496676038889 890.9705459526452 2.5101733075408186 0.9127331066711779 1.0498758510850246 2.393508057892408 0.9405148087892365 0.5566176044060873 3.101553855851603 2.442183062827124 1.0444224804411741 1.0 9.799233929142098 -7.246364973984322 24.986819296053866 2.017221921164051 1.3812228162627822 0.0742740654058458 0.8270531514135632 1800.0430420012483 2983693.9737763577 0.3161929632332975 0.24393114450215544 5.670678505548723e-08 7.246364973984322 -0.6359991049012688 SSGNSSSSGSGSGST(ph)SAGSSSPGAR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSS(0.032)GS(0.095)GS(0.175)GS(0.095)T(0.528)S(0.058)AGS(0.011)S(0.006)S(0.001)PGAR 143.58 1.8010999999999998e-08 2119600.0 63.363 222.08 151.17 118.97 245.23 239.12 214.97 165.96 0.0 210.83 True False 64.83923461706448 196.078770357809 130.64194431737135 98.1941228434874 223.04898979887298 236.7146699035887 198.75463982666008 161.5582016859457 0.0 237.89208415810646 0.27255734400128845 0.8242341104023128 0.5491647390442166 0.4127675083893342 0.9376057660272187 0.9950506371042795 0.8354823597012372 0.6791239072022751 0.0 1.0 7.8941634567633105 -6.249030520387461 24.558743838136245 0.7425722546131432 0.5392550089585958 0.11821366821279666 0.3000936619876765 1631.9512775761352 3229840.906335173 0.09165746554984748 0.11742389747680992 5.6359804713665e-07 6.249030520387461 -0.20331724565454745 SSGNSSSSGSGSGSTS(ph)AGSSSPGAR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNS(0.001)S(0.001)S(0.012)S(0.011)GS(0.087)GS(0.245)GS(0.129)T(0.129)S(0.334)AGS(0.004)S(0.014)S(0.034)PGAR 73.404 0.00049126 342620.0 0.0 67.69800000000001 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 59.77188668805364 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSGNSSSSGSGSGSTSAGS(ph)SSPGAR ddPTM_A459_Selumetinib_30min_R1 2 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGS(0.012)GS(0.005)T(0.015)S(0.044)AGS(0.621)S(0.205)S(0.098)PGAR;SSGNSSSSGSGSGS(0.002)T(0.011)S(0.043)AGS(0.41)S(0.267)S(0.267)PGAR 112.47 1.3629e-07 1232940.0 0.0 274.96000000000004 227.31 210.59 0.0 121.15 0.0 0.0 159.05 265.94 True False 0.0 242.76755537456395 196.44255052445388 173.8144097638902 0.0 119.93134099539886 0.0 0.0 269.8962334476129 300.0759894749649 0.0 0.8090202611656068 0.6546426819025549 0.5792346467573388 0.0 0.3996699009648842 0.0 0.0 0.8994262883872957 1.0 8.229184076351007 -8.380564203982184 6.254886581278094 0.9892938395746299 0.32671512339790054 0.4418508482664061 0.2895406620136925 0.24226388071261235 10.962031707453614 0.29671094735918285 0.07694232385902036 4.163281685455947e-09 8.380564203982184 -0.6625787161767294 SSGNSSSSGSGSGSTSAGS(ph)SSPGAR ddPTM_A459_Selumetinib_30min_R2 4 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGSTSAGS(0.482)S(0.313)S(0.205)PGAR;SSGNSS(0.002)S(0.003)S(0.003)GS(0.018)GS(0.177)GS(0.177)T(0.177)S(0.058)AGS(0.337)S(0.035)S(0.012)PGAR;SSGNSSSS(0.001)GS(0.001)GS(0.001)GS(0.001)T(0.003)S(0.008)AGS(0.417)S(0.283)S(0.283)PGAR;SSGNSSSS(0.001)GS(0.001)GS(0.001)GS(0.004)T(0.006)S(0.022)AGS(0.566)S(0.198)S(0.198)PGAR 168.11 2.9027e-16 24241910.0 8322.83 1533.0 7488.2 10263.16 3900.67 5682.02 9284.7 8599.93 7775.1 5053.6 True False 7860.2804275282715 1650.5761706280841 7006.417364535704 8865.299903061483 3410.632962167756 6464.666678757954 9716.45694728402 8624.954372504952 9330.337254445207 4907.689437170323 1.6016254753194723 0.33632449480743304 1.4276407368954191 1.8064101277307067 0.6949569661714903 1.3172526015593509 1.979843482697295 1.7574368718567348 1.9011670102387113 1.0 12.260828241562177 -7.070456192472811 6.6780946388511335 1.71686106446307 1.1598869175803326 0.1898961292296587 0.46888837201567346 0.3689862052733756 29.115338679826788 0.1765266842033619 0.13719893740374917 8.50244453495386e-08 7.070456192472811 -0.5569741468827374 SSGNSSSSGSGSGSTSAGS(ph)SSPGARR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGARR 26 1 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGSTS(0.001)AGS(0.332)S(0.332)S(0.332)PGARR 72.214 0.00026836 8680600.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSGNSSSSGSGSGSTSAGSS(ph)SPGAR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGSTSAGS(0.102)S(0.449)S(0.449)PGAR 188.23 1.6168e-26 10635000.0 0.0 206.79 137.57 0.0 0.0 0.0 74.983 0.0 0.0 69.954 True False 0.0 182.57893066593712 118.8887496179188 0.0 0.0 0.0 69.32697194084037 0.0 0.0 78.93327730966264 0.0 2.3130793106393246 1.5061929983156166 0.0 0.0 0.0 0.8782984097931745 0.0 0.0 1.0 6.302561746053786 -5.758384818869248 24.999712666540315 0.22971635359317455 1.3770898605474575 0.33807313217178103 0.6377275918585114 77.02727247008053 630407.359963242 0.1689938918610817 0.2774054191880247 1.7442759031342553e-06 5.758384818869248 1.147373506954283 SSGNSSSSGSGSGSTSAGSS(ph)SPGAR ddPTM_A459_Selumetinib_30min_R2 2 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGSTSAGS(0.08)S(0.561)S(0.36)PGAR;SSGNSSSSGSGSGST(0.002)S(0.002)AGS(0.236)S(0.753)S(0.006)PGAR 225.65 7.466199999999999e-36 60594100.0 38997.9 15569.0 37682.1 43575.6 24385.0 26895.9 54281.7 42512.2 40684.2 29539.7 True False 36830.55283896283 16763.09223777471 35257.67471116836 37640.5281078972 21321.53829533406 30600.566088328815 56805.906607148034 42635.903463726405 48822.17681152653 28686.812107642116 1.2838844797659212 0.5843483819280515 1.2290551692837204 1.31211958884305 0.7432522726934179 1.066711978086156 1.9802098049094496 1.486254495750271 1.7019031821427237 1.0 14.80810003353848 -7.137732531747387 8.174246325266335 1.5814611457825676 1.0202764360443117 0.3811557411678044 0.3140173734654959 0.2769797126425668 17.219689191776357 0.11504613051594793 0.08908174312633457 7.282281591783905e-08 7.137732531747387 -0.5611847097382558 SSGNSSSSGSGSGSTSAGSS(ph)SPGARR ddPTM_A459_Selumetinib_30min_R1 1 SSGNSSSSGSGSGSTSAGSSSPGARR 26 1 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGST(0.004)S(0.039)AGS(0.113)S(0.422)S(0.422)PGARR 90.015 2.365e-05 8288000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSGNSSSSGSGSGSTSAGSSS(ph)PGAR ddPTM_A459_Selumetinib_30min_R1 7 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGSTSAGS(0.008)S(0.008)S(0.985)PGAR;SSGNSSSSGSGSGST(0.002)S(0.002)AGS(0.046)S(0.288)S(0.662)PGAR;SSGNSSSSGSGSGS(0.001)T(0.002)S(0.006)AGS(0.021)S(0.072)S(0.899)PGAR;SSGNSSSSGSGSGSTSAGS(0.018)S(0.141)S(0.841)PGAR;SSGNSSSSGSGSGST(0.001)S(0.001)AGS(0.015)S(0.05)S(0.933)PGAR;SSGNSSSSGSGSGST(0.005)S(0.012)AGS(0.142)S(0.142)S(0.699)PGAR;SSGNSSSSGSGS(0.001)GS(0.001)T(0.001)S(0.003)AGS(0.044)S(0.16)S(0.791)PGAR 204.38 1.5997999999999996e-31 32698480.0 744.957 913.59 797.987 569.12 956.993 852.56 785.78 784.808 481.28999999999996 800.8199999999999 True False 762.3130486660115 806.626458083532 689.6247484288305 469.7338757055188 870.4331521208371 843.9840204625443 726.5079819648922 763.9923424243409 816.7139779692023 903.6130476473685 0.8436277570922163 0.8926680067133281 0.7631859126252389 0.5198396337110336 0.9632808583132814 0.9340104402652515 0.804003421438431 0.8454861784183598 0.9038315461419962 1.0 9.819561292334242 SSGNSSSSGSGSGSTSAGSSS(ph)PGAR ddPTM_A459_Selumetinib_30min_R2 4 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGSTS(0.004)AGS(0.013)S(0.077)S(0.905)PGAR;SSGNSSSSGSGSGSTS(0.002)AGS(0.144)S(0.144)S(0.708)PGAR;SSGNSS(0.001)S(0.001)S(0.001)GS(0.001)GS(0.002)GS(0.005)T(0.022)S(0.066)AGS(0.18)S(0.18)S(0.539)PGAR;SSGNS(0.002)S(0.001)S(0.002)S(0.002)GS(0.002)GS(0.002)GS(0.001)T(0.003)S(0.012)AGS(0.206)S(0.206)S(0.558)PGAR 102.46 2.0189e-06 65578330.0 92666.61 36406.0 78156.96 101807.24 62843.0 60251.21 127076.07 113717.93 97712.36 72981.0 True False 87516.57079003115 39198.22313625965 73128.42628446395 87940.91828471505 54948.100516451894 68550.26727147178 132985.3590514557 114048.83034928334 117257.5623114511 70873.84890258969 1.234821759296797 0.5530703319095087 1.0318111322692942 1.2408091227778903 0.7752944332397351 0.9672152469903041 1.8763671101626387 1.6091807079086975 1.654454557316508 1.0 16.112965778267295 -7.242263811794354 23.693083288934552 1.5857656072665673 0.9550022115078594 0.4903313134402837 0.28155186609919064 308.00673266205206 380569.3775894438 0.10321131671926834 0.07978617584314769 5.724481922073124e-08 7.242263811794354 -0.630763395758708 SSGNSSSSGSGSGSTSAGSSS(ph)PGARR ddPTM_A459_Selumetinib_30min_R2 1 SSGNSSSSGSGSGSTSAGSSSPGARR 26 1 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 1 SSGNSSSSGSGSGS(0.003)T(0.021)S(0.052)AGS(0.014)S(0.044)S(0.865)PGARR 65.775 0.0008121000000000001 386750.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSGNSSSSGSGSGSTSAGSSSPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGNSSSSGSGSGSTSAGSSSPGAR 25 0 Q12797;E5RHJ2;E5RG56;Q12797-7;Q12797-6;Q12797-11;Q12797-2 Q12797 ASPH Aspartyl/asparaginyl beta-hydroxylase 0 209.43 6.3414999999999985e-31 220190.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SSGPT(ph)SLFAVTVAPPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGPTSLFAVTVAPPGAR 18 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;A0A1W2PP22 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 S(0.259)S(0.259)GPT(0.457)S(0.025)LFAVTVAPPGAR 236.31 1.9058e-24 12688000.0 29769.0 25157.0 31280.0 39167.0 31850.0 32867.0 29351.0 31003.0 20256.0 33631.0 True False 28114.55815474893 27086.461007495574 29267.47885508893 33832.387033156374 27848.718257387332 37394.130913079825 30715.879657903126 31093.213597177048 24307.765999928255 32659.98564616812 0.8608257964145037 0.8293469966871689 0.896126506979123 1.0358971801056442 0.8526861756491533 1.1449524601204821 0.9404743771376064 0.9520277790086875 0.7442675040728378 1.0 14.995236536394966 -5.52709130109714 24.23927907030916 0.9551185059490068 0.8494989616791134 0.15912317679444465 0.10014259939305263 137.29399218264186 789993.9866311051 0.026897787832923962 0.04686711622907147 2.9710413683745475e-06 5.52709130109714 -0.1056195442698934 SSGPTS(ph)LFAVTVAPPGAR ddPTM_A459_Selumetinib_30min_R2 1 SSGPTSLFAVTVAPPGAR 18 0 A0A1W2PPS1;Q00839-2;Q00839;A0A1W2PP35;A0A1X7SBS1;A0A1W2PP22 A0A1W2PPS1 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 SS(0.001)GPT(0.29)S(0.709)LFAVTVAPPGAR 166.9 1.3875e-07 12535000.0 26097.0 17523.0 22666.0 18567.0 17797.0 26357.0 14738.0 17306.0 18844.0 20267.0 True False 24646.633214568268 18866.957754674444 21207.694236874868 16038.142570138494 15561.18175280132 29987.437504975955 15423.346202792967 17356.357594837467 22613.326545351883 19681.83905001008 1.252252553836205 0.9585972991007048 1.0775260473875283 0.8148701210992924 0.7906365717787612 1.5236095279907595 0.7836333872867977 0.8818463330960212 1.1489437794859065 1.0 14.264577410408009 -4.756550182615976 24.57945970725219 0.9940972180194169 1.252253041177813 0.11607792067704692 0.21048280018374968 279.1722214887908 1403277.9326365413 0.051687080058920046 0.41153461595193175 1.7516600186484472e-05 4.756550182615976 0.25815582315839614 SSGPYGGGGQYFAKPR ddPTM_A459_Selumetinib_30min_R1 2 SSGPYGGGGQYFAKPR 16 1 F8W6I7;P09651-2;P09651;P09651-3;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 ; 204.17 7.718899999999998e-07 39631000.0 3678.2000000000003 5242.7 5597.3 5901.4 5422.9 4718.8 4801.200000000001 4367.0 3016.5 4015.1 False True 3763.8949034686884 4628.882246734891 4837.217403768097 4870.8312729978725 4932.399652490758 4671.333156327598 4439.041618531704 4251.172973984847 5118.780183556898 4530.477195385918 0.8307943603164015 1.0217206813112742 1.0677059380620169 1.0751254366667136 1.0887152588504758 1.0310907559771265 0.9798176719778356 0.9383499332729167 1.1298545302843903 1.0 12.145447302076738 -4.763463679757 4.854005695414894 1.037793395627533 0.8167885321563217 0.5781462403260498 0.05299518424772113 0.13518886808343702 7.9630207795789545 0.013742283536339373 0.10265510552440883 1.723996263581774e-05 4.763463679757 -0.22100486347121118 SSGPYGGGGQYFAKPR ddPTM_A459_Selumetinib_30min_R2 1 SSGPYGGGGQYFAKPR 16 1 F8W6I7;P09651-2;P09651;P09651-3;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 175.6 3.5243e-06 13123000.0 35070.0 35275.0 33275.0 29130.0 29975.0 22837.0 28635.0 29569.0 21519.0 27312.0 False True 33120.94979633329 37980.479072997856 31134.12272708069 25162.44374794714 26209.272520100007 25982.5894563545 29966.58423917604 29655.04089458853 25823.40129109676 26523.43159490183 1.2487430096601675 1.4319594708966026 1.1738346380890283 0.9486873392650939 0.9881554136885436 0.979608892740286 1.1298155041497735 1.1180695374383094 0.9736070990173222 1.0 14.69497982259687 -5.513081806108643 4.6635988974238165 1.027175297759405 1.3364420851233887 0.7688438667503847 0.0704737408635711 0.08718882313638826 4.995951240387996 0.019792096052114527 0.03917323066545979 3.0684439448926036e-06 5.513081806108643 0.3092667873639836 SSGRNS(ph)PSAASTSSNDSK ddPTM_A459_Selumetinib_30min_R1 3 SSGRNSPSAASTSSNDSK 18 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 S(0.009)S(0.009)GRNS(0.961)PS(0.021)AASTSSNDSK;S(0.005)S(0.007)GRNS(0.975)PS(0.013)AASTSSNDSK;S(0.17)S(0.17)GRNS(0.642)PS(0.019)AASTSSNDSK 143.91 0.00015905 66273000.0 3670.3500000000004 3705.1800000000003 4273.2 4225.4 3992.3 4156.299999999999 3867.0 3751.7 2456.0299999999997 3240.65 True False 3755.86201374213 3271.375803108551 3692.9229110074175 3487.5132105814196 3631.1971698978114 4114.4913956184555 3575.30907666044 3652.192728760919 4167.703528666085 3656.6189941041007 1.0271406509122356 0.8946449735078463 1.0099282744420057 0.9537535127954688 0.9930477240731728 1.1252174214083075 0.9777636342274751 0.9987895196764228 1.1397696985619918 1.0 11.836294595795124 -6.536625177264083 24.964399156402 1.0455244070603307 0.9692360340903007 0.27893055246325527 0.05907083293525519 303.5567805281569 551274.5845507625 0.01877333142061761 0.018782084530844855 2.906530085747643e-07 6.536625177264083 -0.07628837297003 SSGRNS(ph)PSAASTSSNDSK ddPTM_A459_Selumetinib_30min_R2 4 SSGRNSPSAASTSSNDSK 18 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 S(0.013)S(0.013)GRNS(0.97)PS(0.004)AASTSSNDSK;S(0.007)S(0.007)GRNS(0.933)PS(0.053)AASTSSNDSK;S(0.007)S(0.007)GRNS(0.824)PS(0.162)AASTSSNDSK;S(0.104)S(0.104)GRNS(0.776)PS(0.015)AAS(0.001)TSSNDSK 126.26 0.00043196 39188800.0 17356.300000000003 13420.989999999998 13565.089999999998 19582.37 16862.5 12292.01 13550.72 16647.1 10537.71 17384.9 True False 16391.706328773857 14450.33677771546 12692.326877953263 16915.21742452755 14744.08199733732 13985.122801742973 14180.855330242288 16695.54030492423 12645.546448218 16882.95276560519 0.9709028128164804 0.8559128831512471 0.7517835922523408 1.00191107914417 0.8733118075988884 0.8283576336382447 0.8399511345629211 0.9888993078827558 0.7490127244791059 1.0 14.043279627655563 -10.710769377227237 4.618269798956847 1.0000223562339368 0.8741251872445405 0.16492026201020227 0.08548901707340227 1.8786594169589112e-05 3.3036484281926843e-06 0.07902331197028602 0.019162565955370744 1.9463933977187954e-11 10.710769377227237 -0.1258971689893963 SSGS(ph)ETEQVVDFSDR ddPTM_A459_Selumetinib_30min_R1 2 SSGSETEQVVDFSDR 15 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 S(0.123)S(0.007)GS(0.87)ETEQVVDFSDR;SSGS(0.998)ET(0.001)EQVVDFSDR 390.99 1.6013999999999983e-266 35110000.0 1819.02 2456.3 2357.8999999999996 2380.86 2277.8999999999996 2283.6000000000004 2298.3999999999996 2088.5699999999997 1230.52 1660.03 True False 1861.3996268032233 2168.7152540971115 2037.7101310175967 1965.087495277342 2071.8643471959076 2260.629057342905 2125.029837547543 2033.1743389685207 2088.1025663750816 1873.1110205615028 0.9937476243374145 1.157814582419677 1.0878747221329956 1.0491035895396459 1.1061086739935067 1.2068847134673502 1.1344921973234254 1.0854531934572869 1.114777791307389 1.0 10.871220696291505 -4.7457306788368365 24.748543146644256 1.1092951679053424 0.9937472612631733 0.27209430989088823 0.053989533218986176 1042.6772653781068 1642601.3818362348 0.013466617672078218 0.3224077370518429 1.795846948951972e-05 4.7457306788368365 -0.11554790664216918 SSGS(ph)ETEQVVDFSDR ddPTM_A459_Selumetinib_30min_R2 2 SSGSETEQVVDFSDR 15 0 O95251;O95251-4;O95251-2 O95251 KAT7 Histone acetyltransferase KAT7 1 S(0.008)S(0.336)GS(0.652)ET(0.004)EQVVDFSDR;S(0.008)S(0.259)GS(0.733)ETEQVVDFSDR 308.78 1.9318999999999993e-94 22801000.0 46131.0 42101.0 47496.0 51204.0 47599.0 33991.4 41264.0 39483.9 33277.7 42252.0 True False 43567.22369702456 45330.011323948434 44440.15906973475 44229.926868173185 41619.18807954098 38673.40680679285 43182.85776306481 39598.79161208849 39934.16985662582 41032.07497612013 1.0617845605512233 1.1047457714563453 1.0830590238392297 1.0779354174487676 1.0143086379073576 0.9425164783721034 1.0524171099852102 0.9650691961138748 0.9732427589846901 1.0 15.324464492153421 -6.330524947478739 3.404344965331934 0.9877925531939368 1.0846330304117713 0.7126442418293719 0.028561084486037187 0.13075954473131263 2.984097322087166 0.008964084251387632 0.010558391406219749 4.671701144246177e-07 6.330524947478739 0.09684047721783451 SSGS(ph)PEPSPAIAK ddPTM_A459_Selumetinib_30min_R1 2 SSGSPEPSPAIAK 13 0 Q66K64;K7ELE9 Q66K64 DCAF15 DDB1- and CUL4-associated factor 15 1 S(0.043)S(0.001)GS(0.956)PEPSPAIAK;SS(0.002)GS(0.979)PEPS(0.019)PAIAK 201.08 0.00010161 58407000.0 8374.5 9360.5 10329.5 11319.1 9254.8 7674.099999999999 8318.1 8166.200000000001 4921.0 7172.900000000001 True False 8569.609556059626 8264.56830842161 8926.81063588204 9342.431670822209 8417.704974067648 7596.905521525299 7690.659020059266 7949.605848444027 8350.57758438041 8093.611584962681 1.0588115658998651 1.021122427443461 1.1029452725983762 1.1542970122484926 1.040043111249261 0.9386298615614043 0.9502135034930426 0.9822074811711738 1.03174923786745 1.0 12.982567899929126 -6.54851806469801 7.043723076410592 0.9784246194134983 1.0831424834441368 0.6063253418241563 0.039504589780317935 0.127551201684629 23.547430630814915 0.014141853405253013 0.014330554650018822 2.8280164758293274e-07 6.54851806469801 0.10471786403063843 SSGS(ph)PEPSPAIAK ddPTM_A459_Selumetinib_30min_R2 3 SSGSPEPSPAIAK 13 0 Q66K64;K7ELE9 Q66K64 DCAF15 DDB1- and CUL4-associated factor 15 1 SS(0.001)GS(0.998)PEPS(0.001)PAIAK;S(0.057)S(0.057)GS(0.882)PEPS(0.004)PAIAK;S(0.07)S(0.304)GS(0.626)PEPSPAIAK 165.51 0.00035639 32705600.0 177037.0 166931.0 201905.0 213111.0 188875.0 162304.0 171635.0 184953.0 158322.0 180829.0 True False 167197.9922752623 179734.07093223537 188914.65211754275 184084.91416301945 165146.83393607644 184659.9027509814 179616.36758830023 185491.1826093827 189990.82388628752 175607.99691983406 0.9521092160261303 1.0234959346087462 1.0757747678414853 1.0482718178663306 0.9404288918087643 1.0515460912368335 1.0228256727414071 1.056279815628558 1.081903029581388 1.0 17.42199901893361 -7.319307247934727 2.104000810962849 1.0490171894295124 1.0154182589064673 0.08756482068801508 0.04391637022236574 0.8580053709521903 7.41579636764082 0.02335185061663986 0.01434851503481148 4.793941742718666e-08 7.319307247934727 -0.03359893052304508 SSGS(ph)PYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R1 26 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 S(0.001)S(0.001)GS(0.997)PYGGGYGSGGGSGGYGSR;S(0.003)S(0.063)GS(0.922)PYGGGYGS(0.01)GGGSGGYGSR;S(0.034)S(0.004)GS(0.962)PYGGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.012)S(0.001)GS(0.987)PYGGGYGSGGGSGGYGSR;SS(0.001)GS(0.999)PYGGGYGSGGGSGGYGSR;S(0.328)S(0.008)GS(0.664)PYGGGYGSGGGSGGYGSR;S(0.058)S(0.179)GS(0.763)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.001)GS(0.999)PYGGGYGSGGGSGGYGSR;S(0.005)S(0.014)GS(0.982)PYGGGYGSGGGSGGYGSR;S(0.008)S(0.008)GS(0.985)PYGGGYGSGGGSGGYGSR;S(0.009)S(0.028)GS(0.959)PYGGGYGS(0.004)GGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.004)S(0.001)GS(0.995)PYGGGYGSGGGSGGYGSR;SS(0.003)GS(0.996)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.001)GS(0.998)PYGGGYGSGGGSGGYGSR;SSGS(0.999)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.011)GS(0.988)PYGGGYGSGGGSGGYGSR;S(0.014)S(0.006)GS(0.98)PYGGGYGSGGGSGGYGSR;S(0.013)S(0.013)GS(0.958)PY(0.01)GGGY(0.002)GS(0.001)GGGS(0.001)GGY(0.001)GS(0.001)R;S(0.001)S(0.002)GS(0.997)PYGGGYGSGGGSGGYGSR;S(0.01)S(0.001)GS(0.989)PYGGGYGSGGGSGGYGSR;S(0.03)S(0.008)GS(0.917)PY(0.011)GGGY(0.001)GS(0.01)GGGS(0.003)GGY(0.001)GS(0.02)R;S(0.007)S(0.007)GS(0.986)PYGGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;SS(0.001)GS(0.999)PYGGGYGSGGGSGGYGSR 351.02 1.5105999999999984e-206 1355815200.0 34270.939999999995 39997.39 40872.78 42688.68 41421.21 34555.310000000005 37031.86 35361.420000000006 19264.859999999997 30683.010000000002 True False 35069.3862223591 35314.476984517845 35322.48097410976 35233.90340376837 37674.66886900861 34207.71495511115 34238.51698567847 34423.520271519876 32691.060370296036 34621.47321132679 1.0129374336065449 1.0200165882301142 1.020247773932209 1.0176893163587624 1.0881879184933971 0.9880490857887505 0.9889387657390897 0.9942823652073202 0.9442423252977231 1.0 15.079379495052812 -6.9649230011699705 24.99969388780888 0.9824042603982571 1.0305714149544996 0.49957483660655266 0.024421878819330636 155.46407941614657 110800.23584339432 0.008606103814929805 0.007589847197687268 1.084119107352704e-07 6.9649230011699705 0.04816715455624243 SSGS(ph)PYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R2 31 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 SS(0.001)GS(0.999)PYGGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.001)GS(0.967)PY(0.03)GGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.002)S(0.002)GS(0.996)PYGGGYGSGGGSGGYGSR;S(0.001)SGS(0.999)PYGGGYGSGGGSGGYGSR;SS(0.049)GS(0.951)PYGGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.006)S(0.056)GS(0.938)PYGGGYGSGGGSGGYGSR;S(0.023)S(0.07)GS(0.907)PYGGGYGSGGGSGGYGSR;SS(0.002)GS(0.993)PY(0.005)GGGYGSGGGSGGYGSR;SSGS(0.999)PYGGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.048)S(0.006)GS(0.945)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.001)GS(0.998)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.002)GS(0.998)PYGGGYGSGGGSGGYGSR;S(0.005)S(0.013)GS(0.982)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.026)GS(0.974)PYGGGYGSGGGSGGYGSR;S(0.006)S(0.018)GS(0.976)PYGGGYGSGGGSGGYGSR;S(0.115)S(0.115)GS(0.767)PY(0.003)GGGYGSGGGSGGYGSR;S(0.007)S(0.007)GS(0.777)PY(0.03)GGGY(0.025)GS(0.097)GGGS(0.039)GGY(0.016)GS(0.002)R;S(0.15)S(0.014)GS(0.813)PY(0.022)GGGYGSGGGSGGYGSR;S(0.029)S(0.004)GS(0.966)PYGGGYGSGGGSGGYGSR;S(0.001)S(0.002)GS(0.889)PY(0.108)GGGYGSGGGSGGYGSR;SSGS(1)PYGGGYGSGGGSGGYGSR;S(0.004)S(0.016)GS(0.964)PYGGGYGS(0.009)GGGS(0.001)GGYGS(0.005)R;SS(0.008)GS(0.992)PYGGGYGSGGGSGGYGSR;SS(0.001)GS(0.999)PYGGGYGSGGGSGGYGSR;SS(0.001)GS(0.999)PYGGGYGSGGGSGGYGSR;S(0.003)S(0.042)GS(0.956)PYGGGYGSGGGSGGYGSR;SS(0.003)GS(0.997)PYGGGYGSGGGSGGYGSR 306.67 2.648699999999998e-157 1774783000.0 513267.39999999997 473317.29999999993 541784.7 607456.0 591401.4999999999 430255.6 482439.4 485235.50000000006 423205.5 527729.9999999999 True False 484742.0526801971 509619.2149550062 506926.8622525808 524719.4448799522 517104.3563735086 489519.40342853626 504873.7880355348 486647.454969939 507858.4253496559 512493.06369279313 0.9458509529619098 0.9943924143732223 0.9891389721450964 1.023856676418333 1.008997766033141 0.9551727391221276 0.985132919453861 0.9495688614073674 0.9909566808382886 1.0 18.967172953115913 -6.755425211623061 24.999834422921957 0.9735747114988809 0.9941165759550428 0.10044545335390787 0.02347186023903456 293.1332005392844 1218503.583908921 0.007906095887265407 0.007705110530230646 1.7562032979625675e-07 6.755425211623061 0.020541864456161907 SSGS(ph)TTELHCVTDER ddPTM_A459_Selumetinib_30min_R1 1 SSGSTTELHCVTDER 15 0 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7 P25054-2 APC Adenomatous polyposis coli protein 1 SS(0.005)GS(0.896)T(0.098)T(0.001)ELHCVTDER 164.66 9.2752e-05 3634200.0 902.59 940.49 1265.8 1495.4 1017.0 1122.6 855.55 709.61 586.24 693.94 True False 923.618590865587 830.376993578061 1093.9113125416998 1234.2564621345812 925.0125295659333 1111.3076632392472 791.0151746927429 690.7888376618704 994.8064627244802 783.0139585480076 1.1795684876145904 1.0604881107328938 1.3970521222510628 1.5762892202117842 1.1813487096465594 1.4192692877404323 1.0102184846864959 0.882217781842413 1.2704836891659157 1.0 9.612894215999203 -7.2744187928491035 24.70297761497305 1.0309147763027475 1.3026011801810353 0.38050694803202745 0.16333513194423388 747.0270959893559 1421768.3072842488 0.0708494938547278 0.048105476817549175 5.31595391309142e-08 7.2744187928491035 0.2716864038782878 SSGSPY(ph)GGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 S(0.001)S(0.001)GS(0.168)PY(0.83)GGGYGSGGGSGGYGSR 78.814 0.01939 2656600.0 323.62 315.06 316.05 414.88 247.82 413.24 296.04 363.52 155.51 364.03 True False 331.1597163450972 278.1726287325796 273.1321459383821 342.42899626213386 225.40472475617457 409.08318079189974 273.70946445682875 353.8782687206255 263.88911199898325 410.756796452476 0.8062184708936688 0.6772197834218034 0.6649485736993352 0.8336538779626801 0.5487547052243446 0.9959255314214384 0.6663540733123245 0.8615274823859639 0.6424461245147404 1.0 8.682140636227404 -6.754324878430041 24.99996544323454 0.8141650757701046 0.7093449641348367 0.180546898940112 0.13220428640859822 338.6819138288293 1190108.2227766092 0.0412093346056048 0.04037166214398306 1.760658475077811e-07 6.754324878430041 -0.10482011163526783 SSGSPYGGGYGS(ph)GGGSGGYGSR ddPTM_A459_Selumetinib_30min_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 SSGSPYGGGYGS(0.929)GGGS(0.06)GGYGS(0.01)R 128.72 2.2773e-05 0.0 0.0 193.22 181.02 331.7 123.28 352.44 188.77 277.25 115.38 0.0 True False 0.0 170.597712574459 156.43847827168463 273.77482178015276 112.1293457668518 348.8947735899162 174.53092692040113 269.8964293650785 195.79143297821807 0.0 0.0 SSGSPYGGGYGSGGGSGGYGSR ddPTM_A459_Selumetinib_30min_R1 3 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;P51991-2;H7C1J8 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 ;; 345.69 7.961599999999994e-183 8014400.0 1700.21 1475.31 2181.5299999999997 2063.85 1789.0700000000002 1817.21 1391.3600000000001 1570.4299999999998 1497.0700000000002 1739.6100000000001 False True 1739.82158496724 1302.580019346988 1885.2902082865332 1703.4373407626424 1627.2489343859636 1798.9305172946647 1286.408595009638 1528.7770949244375 2540.4184483333415 1962.9058887363442 0.886349974775042 0.6635977948925239 0.9604587866921234 0.8678140661441801 0.8289999758641176 0.9164629479270442 0.655359282577621 0.7788336179013733 1.2942130658993445 1.0 10.938775289301043 -8.249673876821069 24.99353837818063 1.1471065360498107 0.8188773970090322 0.5643761256555457 0.11504441270519872 448.34681566153273 952431.4348586572 0.07658190930759393 0.028414416736347328 5.627637607096717e-09 8.249673876821069 -0.32822913904077855 SSGSS(ph)PAMETR ddPTM_A459_Selumetinib_30min_R2 1 SSGSSPAMETR 11 0 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 SS(0.002)GS(0.188)S(0.81)PAMETR 124.21 0.0036397 4495700.0 19494.0 15563.0 21404.0 23427.0 22175.0 15077.0 17712.0 15325.0 16979.0 23198.0 True False 18410.601520664997 16756.632057067764 20026.88994291316 20236.202186170874 19389.178252984744 17153.719894620874 18535.64309566217 15369.593212809681 20375.274432898 22528.213464357526 0.817224213086976 0.7438065199257308 0.8889692906451825 0.898260406586927 0.8606620442256049 0.7614327661516622 0.822774656542912 0.6822375523530223 0.9044336544988023 1.0 14.459445288848189 -8.52348603886154 24.964896195241177 1.0000000061817775 0.8121462241156693 0.4818565370137412 0.0631889256983236 49.145604249771225 2020332.894642275 0.06348737083237313 0.01639236865724616 2.9958078962456207e-09 8.52348603886154 -0.18785378206610825 SSGSSSSGLGTVSNS(ph)PASQR ddPTM_A459_Selumetinib_30min_R1 3 SSGSSSSGLGTVSNSPASQR 20 0 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;H0Y3N9;Q9UPP1-5;H0Y589 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 SSGSSSSGLGTVS(0.003)NS(0.988)PAS(0.009)QR;SSGSSSSGLGTVSNS(0.999)PAS(0.001)QR;SSGSSSSGLGTVS(0.001)NS(0.817)PAS(0.182)QR 288.3 1.3293999999999995e-85 23697000.0 2999.04 4643.61 4016.8300000000004 4276.42 3511.7299999999996 3954.2799999999997 3788.47 3372.29 2218.1 3250.36 True False 3068.911796884001 4099.933982444277 3471.366548867811 3529.623525345436 3194.094641546288 3914.5035333989726 3502.7026577853057 3282.8459144582926 3763.953696385729 3667.575367187512 0.8367685704131563 1.117886770405572 0.9465017624245405 0.9623860921642452 0.8709008873062878 1.0673273597648842 0.9550458564867506 0.8950997827689496 1.0262784863429064 1.0 11.84061089766381 -6.76005179281205 24.99999844434775 0.9800874888314873 0.9572281806895592 0.05003347079157072 0.08118292643742935 224.048456668155 4036706.4955622875 0.02715452762594892 0.025765887428379434 1.73759359557292e-07 6.76005179281205 -0.02285930814192816 SSGSSSSGLGTVSNS(ph)PASQR ddPTM_A459_Selumetinib_30min_R2 2 SSGSSSSGLGTVSNSPASQR 20 0 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;H0Y3N9;Q9UPP1-5;H0Y589 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 SSGSSSSGLGTVSNS(0.999)PAS(0.001)QR;SSGSSSSGLGTVSNS(1)PASQR 210.2 7.9511e-17 26083000.0 23770.0 22210.0 31826.0 32682.0 34141.0 23824.0 30935.0 30491.0 21412.2 34620.0 True False 22448.958558849215 23913.435583594095 29778.349809528794 28230.655220405377 29851.90235558745 27105.53974726058 32373.53879653959 30579.72376194321 25695.238306855448 33620.43064643754 0.6677177575424047 0.7112768969283857 0.8857218434435533 0.8396874958946051 0.8879095770520891 0.8062222650361177 0.9629126746468349 0.9095577651437213 0.764274514418754 1.0 15.037050583823135 -5.196579822476263 3.725470176563873 0.8783341849973988 0.6765322583770196 0.5806090705367314 0.06570335535797778 0.15822040030393908 4.333746435110367 0.01649115805730684 0.04946642028170434 6.359459084809052e-06 5.196579822476263 -0.2018019266203792 SSGTPGCSSGTERPQS(ph)PGSSK ddPTM_A459_Selumetinib_30min_R1 2 SSGTPGCSSGTERPQSPGSSK 21 1 Q8IYD8-2;Q8IYD8-3;Q8IYD8 Q8IYD8-2 FANCM Fanconi anemia group M protein 1 S(0.041)S(0.012)GT(0.124)PGCS(0.001)S(0.001)GT(0.001)ERPQS(0.809)PGS(0.009)S(0.003)K;SSGTPGCS(0.028)S(0.007)GT(0.04)ERPQS(0.905)PGS(0.016)S(0.005)K 77.83800000000002 0.0013883 28171000.0 3229.7 3575.3999999999996 4227.8 4527.0 3875.7 3157.2 3245.0 2953.6000000000004 1888.0 2494.6000000000004 True False 3304.9457260977706 3156.7905058416363 3653.68798164307 3736.4444323145945 3525.1436193104087 3125.4414345082387 3000.227037435511 2875.2609333550818 3203.7981059358262 2814.80620946171 1.174129044830334 1.1214947925119598 1.2980246985961368 1.3274251064797582 1.2523574828920605 1.1103575883847199 1.0658733902712472 1.021477401779973 1.138194912021494 1.0 11.458819885378794 -6.888282995852296 3.6868518223328275 1.0609974503164632 1.2370611413364363 0.6373783940506883 0.0640297657595527 0.16898482026642558 4.391045431813482 0.02596546347468527 0.02270334836661029 1.2933527896328286e-07 6.888282995852296 0.1760636910199731 SSGTPGCSSGTERPQS(ph)PGSSK ddPTM_A459_Selumetinib_30min_R2 1 SSGTPGCSSGTERPQSPGSSK 21 1 Q8IYD8-2;Q8IYD8-3;Q8IYD8 Q8IYD8-2 FANCM Fanconi anemia group M protein 1 SSGT(0.002)PGCS(0.079)S(0.079)GT(0.079)ERPQS(0.705)PGS(0.043)S(0.013)K 54.834 0.018695 8897600.0 15227.0 8742.4 15893.0 17965.0 17551.0 10429.0 12114.0 14248.0 12912.0 14148.0 True False 14380.744298510604 9412.913968753403 14870.46168299003 15518.136008646423 15346.086472069237 11865.500084963915 12677.325003435608 14289.459321116616 15494.760791423467 13739.510479081397 1.0466707908120523 0.6850982051423666 1.0823137917199104 1.129453340588299 1.1169310941196833 0.8636042821925359 0.9226911703103993 1.0400268148470446 1.1277520269018655 1.0 13.746042983270051 -5.2983539661623595 24.9968431570695 1.032893734598761 0.8658841808285517 0.25354730956424465 0.11624555269098741 697.7876900620067 472508.18761100166 0.031027480914730655 0.06459137404981714 5.030904042457425e-06 5.2983539661623595 -0.16700955377020932 SSHCDS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 SSHCDSPPR 9 0 F6RP06;A0A0J9YW18;Q12983 F6RP06 BNIP3 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 1 S(0.042)S(0.183)HCDS(0.776)PPR 82.505 0.027233 1277800.0 3776.6 2174.5 2150.7 4868.5 5347.1 3768.4 6020.9 7912.4 6362.5 7728.1 True False 3566.7116909276388 2341.2771578804773 2012.3263035051068 4205.401901369056 4675.349494319489 4287.462893870748 6300.883780187016 7935.423774031666 7635.177783103454 7504.969672984799 0.4752466493990672 0.311963573458296 0.26813250301980035 0.5603489533751209 0.6229671401803356 0.5712831737753822 0.8395615245279323 1.057355874814038 1.0173495851138956 1.0 12.873630526698213 -7.081597293077217 0.8175465162539872 1.067527343984923 0.36426948266920606 0.895156261377929 0.08925763701584324 0.19372070818828654 0.2645038880569457 0.07178201127271552 0.05005374008427192 8.287102431755739e-08 7.081597293077217 -0.703257861315717 down SSHYDELLAAEAR ddPTM_A459_Selumetinib_30min_R2 2 SSHYDELLAAEAR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 ; 142.12 0.002043 3802100.0 26068.0 21509.8 34685.0 38325.0 37263.0 26809.0 26906.0 31023.0 29126.0 31220.0 False True 24619.24491847209 23159.532495091946 32453.404862172625 33105.06888568741 32581.688804553338 30501.69640212847 28157.18231322755 31113.271793865864 34952.01384843552 30318.59748069844 0.8120179350032699 0.7638721583290873 1.0704124715146621 1.0919063425266589 1.0746436679762523 1.006039161987839 0.9287099223884976 1.0262107874110382 1.152824231750391 1.0 14.887915396434405 -5.260864466233741 24.99983360125855 1.0421339196170492 0.7879450258095752 0.7552730053028109 0.058259645684290234 24.174088722279535 1051137.315828464 0.016171946650748354 0.037868318534876586 5.484480968177064e-06 5.260864466233741 -0.254188893807474 SSIETKPDAS(ph)PQLPK ddPTM_A459_Selumetinib_30min_R2 2 SSIETKPDASPQLPK 15 1 E9PRD6;A0A024R3M2;A0A2R8Y5X2;J3KNL5;A0A1B0GWG7;A0A1B0GUD6;Q3KR37-2;Q3KR37;Q3KR37-4 E9PRD6 GRAMD1B;hCG_39893 GRAM domain-containing protein 1B 1 SSIET(0.007)KPDAS(0.993)PQLPK;SSIETKPDAS(1)PQLPK 114.99 0.0013344 36620000.0 335290.0 74950.0 233454.0 213296.0 114197.0 119348.0 359740.0 232408.0 201050.0 131498.0 True False 316655.9240722153 80698.42399776589 218433.82380549688 184244.71684387643 99850.55192586691 135787.10366672493 376468.622811287 233084.26880278438 241265.61780635777 127701.31106716463 2.4796607131595523 0.6319310532005616 1.710505726057984 1.4427785846847943 0.7819070226565679 1.0633180077165187 2.9480403894466125 1.8252300376163992 1.8892963258573272 1.0 16.96241381122676 SSINSVDGES(ph)PNGSSDR ddPTM_A459_Selumetinib_30min_R1 4 SSINSVDGESPNGSSDR 17 0 E9PGE5;Q9NUY8-2;Q9NUY8 E9PGE5 TBC1D23 TBC1 domain family member 23 1 SSINS(0.025)VDGES(0.975)PNGSSDR;SSINSVDGES(0.999)PNGSSDR;SSINSVDGES(0.997)PNGS(0.001)S(0.001)DR;SSINSVDGES(0.998)PNGS(0.002)SDR 344.29 5.277599999999997e-155 34726200.0 7148.179999999999 7594.2 8418.300000000001 8976.6 8026.0 6499.4 7324.599999999999 7504.7 3970.59 5722.31 True False 7314.718686062968 6705.067533552204 7275.141098411906 7409.005321651247 7300.049717105386 6434.02193698304 6772.09952493071 7305.650977298844 6737.801229580374 6456.824228519539 1.1328663174311209 1.038446656784644 1.1267367425425479 1.147468950591215 1.1305944623459552 0.9964684974022087 1.0488282296765354 1.1314619569524706 1.0435162846496224 1.0 12.656609038385916 -6.7351265794694415 24.99998659452917 1.052569654082648 1.1133884426749086 0.3821046127607095 0.04456707485187204 293.34212080250904 278705.9261817209 0.015334108821817648 0.01532953197648757 1.840235568240696e-07 6.7351265794694415 0.06081878859226064 SSINSVDGES(ph)PNGSSDR ddPTM_A459_Selumetinib_30min_R2 3 SSINSVDGESPNGSSDR 17 0 E9PGE5;Q9NUY8-2;Q9NUY8 E9PGE5 TBC1D23 TBC1 domain family member 23 1 SSINSVDGES(0.997)PNGS(0.002)S(0.001)DR;SSINSVDGES(0.577)PNGS(0.321)S(0.102)DR;SSINSVDGES(1)PNGSSDR 259.34 3.7524e-40 68076600.0 104085.0 101184.0 112995.0 144061.0 130878.0 101382.0 91081.0 110069.0 88151.0 127169.0 True False 98300.37238526801 108944.48744216033 105725.02471965377 124439.64328091373 114435.93557583478 115346.45024583499 95316.44697357752 110389.28256709615 105783.66314473144 123497.30054525747 0.7959718305684288 0.8821608809354984 0.8560917870501081 1.0076304723382268 0.9266270199476788 0.9339997695218003 0.7718099630740297 0.8938598826023918 0.85656660248995 1.0 16.91411998157038 -4.600183878429355 1.7013428627553622 0.9025150867070556 0.7186458973066161 0.2004331669978915 0.06589569516503425 2.9147727759068793 5.791581316437996 0.01862107248848552 1.0133828925614998 2.5108231346329007e-05 4.600183878429355 -0.1838691894004395 SSISGS(ph)LPSSGSLQAVSSR ddPTM_A459_Selumetinib_30min_R1 2 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 S(0.015)SIS(0.009)GS(0.964)LPS(0.009)S(0.002)GSLQAVSSR;S(0.017)S(0.002)IS(0.002)GS(0.851)LPS(0.096)S(0.026)GS(0.007)LQAVSSR 271.2 9.503999999999999e-59 16558800.0 2934.8 2724.8999999999996 3978.2 3203.1 3594.8 3149.5 3251.0 2949.2 1700.0900000000001 2841.6000000000004 True False 3003.175129873282 2405.8674412283563 3437.98229068841 2643.738714633728 3269.6509747134864 3117.8188895171998 3005.7744526048823 2870.9776356482953 2884.9285603392186 3206.3470395279387 0.9366344606026897 0.7503453031031118 1.0722427261630962 0.8245329286074279 1.0197433198606187 0.9723897167339152 0.9374451410123759 0.8954045211746577 0.8997555550830076 1.0 11.646714868953612 -5.2502646530088795 24.998980537610958 0.9469306226319546 0.8434899036437452 0.2334615985483045 0.07859565649437358 1057.8477568550745 2366499.7900813976 0.018730573351183943 0.048527665263241995 5.619987466103801e-06 5.2502646530088795 -0.10344071898820939 SSISGS(ph)LPSSGSLQAVSSR ddPTM_A459_Selumetinib_30min_R2 2 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 SSIS(0.031)GS(0.81)LPS(0.103)S(0.053)GS(0.003)LQAVSSR;SSIS(0.251)GS(0.556)LPS(0.093)S(0.093)GS(0.007)LQAVSSR 196.01 3.3073e-15 12701500.0 39980.0 30372.0 36350.0 39857.0 42097.0 31758.0 37888.0 33010.0 29654.0 33306.0 True False 37758.07165262059 32701.43473862765 34011.28057488756 34428.407842839995 36808.39850804503 36132.37622957948 39649.86707364771 33106.0536349003 35585.62860198815 32344.36924061954 1.1673769666592313 1.0110394948608146 1.0515363685675043 1.0644328101351015 1.1380156537979216 1.117114882061227 1.2258661400591973 1.023549211567997 1.100210931221317 1.0 14.981226958051872 -4.680228718736407 22.258612080019155 1.0879941447193748 1.1674001851695497 0.12923616522968673 0.06496964644997023 83662.91360525411 22909278.817824725 0.016485072368791327 314.2648013695351 2.088196104531858e-05 4.680228718736407 0.07940604045017485 SSISGSLPS(ph)SGSLQAVSSR ddPTM_A459_Selumetinib_30min_R2 1 SSISGSLPSSGSLQAVSSR 19 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 SSIS(0.021)GS(0.079)LPS(0.709)S(0.189)GS(0.002)LQAVSSR 225.69 1.8261e-20 7265000.0 13654.0 11019.0 12691.0 13877.0 13474.0 11041.0 9609.8 13954.0 9791.0 11908.0 True False 12895.165341292684 11864.121868330632 11874.474876916036 11986.928660839765 11781.275660911673 12561.797529781064 10056.674741457455 13994.60382979094 11749.473583397395 11564.185099300348 1.115095030956644 1.0259366973508952 1.026831962213616 1.0365562776719126 1.0187726640266646 1.0862674215186225 0.8696397242954802 1.2101677471971315 1.0160226148670224 1.0 13.49737598580717 -11.065454663091279 2.734840597435801 0.9975414078752751 1.0438247919724934 0.026350341980004965 0.08182504613819473 57211703.449784435 63729754.96060442 1050783.4017406306 0.019554497027962057 8.600928490927676e-12 11.065454663091279 0.04628338409721833 SSKAS(ph)LGS(ph)LEGEAEAEASSPK ddPTM_A459_Selumetinib_30min_R1 1 SSKASLGSLEGEAEAEASSPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 2 S(0.335)S(0.335)KAS(0.486)LGS(0.844)LEGEAEAEASSPK 62.792 0.028010000000000004 9602700.0 2514.2 2631.7 3604.9 3648.4 3078.6 2900.6 2822.8 2757.2 1486.0 2380.6 True False 2572.775968218415 2323.579340555861 3115.374380298289 3011.2754289499835 2800.1411735709744 2871.4225975340814 2609.873923350681 2684.0700993521896 2521.633466854151 2686.173199007675 0.9577848402213412 0.8650147136507195 1.1597816482753864 1.1210280223413769 1.042427634452388 1.0689640558527056 0.971595548758665 0.9992170647610279 0.9387456727606737 1.0 11.391336614480913 -7.278169099454135 23.16439804568423 0.977324310990738 1.0378752162118339 0.11717822507239284 0.078468236827155 802.1741553388173 1110702.606075682 0.03598449792303251 0.024359845578910126 5.270246160630055e-08 7.278169099454135 0.06055090522109585 SSKPEGEAGRS(ph)PGEADEGR ddPTM_A459_Selumetinib_30min_R1 2 SSKPEGEAGRSPGEADEGR 19 2 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 SSKPEGEAGRS(0.999)PGEADEGR;S(0.001)S(0.001)KPEGEAGRS(0.999)PGEADEGR 88.765 0.0034615 18035900.0 2318.12 2687.0 2639.7 2908.5 2764.0 2559.74 2524.18 2160.98 1336.54 1931.58 True False 2372.127685723679 2372.404790847589 2281.2432388341954 2400.5850743068263 2513.996688023835 2533.991339657964 2333.7790703710243 2103.6637905476914 2268.0107629806525 2179.517108182495 1.0883730514516596 1.0885001920567365 1.0466737013762328 1.1014297916242008 1.1534649939592643 1.1626388846156228 1.0707780460219323 0.9651971909970195 1.0406024134731167 1.0 11.089792812874839 -7.577985114194951 5.908083395604298 1.0035119285137402 1.1061112887293711 0.6371865509359889 0.03536787962561281 0.13964659012505096 10.293582785164334 0.018599787063952645 0.01064374850123622 2.64249932963492e-08 7.577985114194951 0.10259936021563099 SSLAETLDSTGS(ph)LDPQR ddPTM_A459_Selumetinib_30min_R1 1 SSLAETLDSTGSLDPQR 17 0 Q9UGH3-2;Q9UGH3 Q9UGH3-2 SLC23A2 Solute carrier family 23 member 2 1 SSLAETLDS(0.001)T(0.008)GS(0.991)LDPQR 156.72 4.4834e-05 5380600.0 1063.1 859.59 1113.1 837.41 880.78 997.32 1182.5 1288.8 501.66 1078.8 True False 1087.8681615674955 758.9488031874506 961.9471338206398 691.1720636325525 801.1136045143386 987.2878662941077 1093.3030729637885 1254.6168373876048 851.2803802032663 1217.2744884018643 0.8936917449044185 0.6234820580063741 0.7902466888002896 0.5678029649171229 0.6581207543140947 0.8110642880475533 0.8981565648345794 1.030677016023532 0.6993331317744903 1.0 10.249438808839109 -7.015514748187976 3.2610163593376233 0.9078632272366455 0.6996898754894508 0.39002028755561924 0.11769844295666299 0.25021164304151 5.499678691654064 0.044954734860474924 0.03617073748590247 9.649065440286129e-08 7.015514748187976 -0.20817335174719465 SSLASPFPPGS(ph)PPENGASSLPGLMPAQHYLLR ddPTM_A459_Selumetinib_30min_R1 1 SSLASPFPPGSPPENGASSLPGLMPAQHYLLR 32 0 P08151-3;P08151-2;P08151 P08151-3 GLI1 Zinc finger protein GLI1 1 SSLAS(0.001)PFPPGS(0.675)PPENGAS(0.282)S(0.042)LPGLMPAQHYLLR 67.72800000000001 0.00012906 8723600.0 873.87 992.58 1291.5 1303.5 1287.0 853.66 1113.5 1038.9 652.93 1005.7 True False 894.2294707449797 876.3682721620769 1116.1213937016942 1075.8681947254422 1170.5910772383045 845.0729554612642 1029.5077985160065 1011.3449971772055 1107.9745218795974 1134.7913913475672 0.7880122087312279 0.7722725770076452 0.9835476389861378 0.9480757458406927 1.0315473717581036 0.7446945420142271 0.9072220730309416 0.8912166631580022 0.9763684588441187 1.0 10.148211395985092 -5.249426474474563 24.518485364999712 0.9275276379066393 0.7801423591329085 0.39903739563172336 0.07569732901175617 617.5054455628153 1260328.4239573309 0.019672714731307273 0.05112709520054562 5.630844388329839e-06 5.249426474474563 -0.14738527877373075 SSLFS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 SSLFSPR 7 0 Q7RTP6 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 SSLFS(1)PR;SSLFS(1)PR;SSLFS(1)PR 106.68 0.017016999999999997 43310000.0 13116.099999999999 15410.2 14532.4 13858.900000000001 14499.8 12080.099999999999 14196.2 13782.2 7522.700000000001 12314.199999999999 True False 13421.679610512118 13605.96661999238 12558.979900759197 11438.703278772868 13188.295650147615 11958.585161853212 13125.369204573808 13416.651285105097 12765.47246373064 13894.847520465553 0.9659465201574532 0.9792094947391338 0.903858778029858 0.8232334512433432 0.9491500810442671 0.8606488947964025 0.944621319898733 0.965584635984229 0.9187198668375836 1.0 13.762262382301296 -7.504441938926198 23.596652969543047 0.956311966236338 0.9127859841227061 0.17044886462777387 0.04773457109057344 736.0186282166691 942011.3389168503 0.02129102417900212 0.01403569472467539 3.1300989082778806e-08 7.504441938926198 -0.0435259821136319 SSLFS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SSLFSPR 7 0 Q7RTP6 Q7RTP6 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 1 SSLFS(1)PR;SSLFS(1)PR 132.76 0.0034751 48788000.0 90708.0 96908.0 118183.0 123375.0 125186.0 90709.0 105934.0 96060.0 83499.0 114592.0 True False 85666.81249289423 104340.53199166742 110579.23444792096 106571.11216625407 109459.01550296052 103203.34137568252 110860.14090423883 96339.51869641097 100201.13315699076 111283.43121422762 0.7698074327702946 0.9376106654260625 0.9936720430110477 0.9576548009298703 0.9836056842302519 0.9273917981285964 0.9961962863171074 0.8657130504086572 0.9004137638791643 1.0 16.763879282889654 -4.7645189639940195 5.091225150265509 0.9511074842020518 0.7592150879545949 0.626827643656799 0.042148904218789716 0.11168496334329538 7.889574336243899 0.010803717633225369 0.07637039057035117 1.7198122419162007e-05 4.7645189639940195 -0.1918923962474569 SSLGQS(ph)AS(ph)ETEEDTVSVSKK ddPTM_A459_Selumetinib_30min_R1 1 SSLGQSASETEEDTVSVSKK 20 1 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 2 S(0.145)S(0.149)LGQS(0.848)AS(0.489)ET(0.369)EEDT(0.001)VSVSKK 83.992 0.0065904 7622800.0 2406.7 2406.1 4283.8 4317.7 3798.0 3159.0 3092.7 2621.4 1751.5 1878.0 True False 2462.7714273770043 2124.3926934344568 3702.083489229049 3563.694748267006 3454.4715705913623 3127.223328142509 2859.4151490529453 2551.8719564927565 2972.167575501378 2119.0595932690976 1.1622001736995318 1.0025167296768336 1.747040763265087 1.6817340860005043 1.6301908552095552 1.475759972997317 1.3493792992587303 1.2042473768073478 1.4025880088233766 1.0 11.049208445144643 -8.739720883164882 0.7664067324156596 1.0081198543332313 1.4483006406613426 0.23308991601395168 0.22533974861280914 1.5646607557863002 1.8884462608700292 0.24942139242018166 0.09002017478960357 1.8208707385296926e-09 8.739720883164882 0.4401807863281113 SSLGQS(ph)ASETEEDTVSVSK ddPTM_A459_Selumetinib_30min_R1 2 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.688)AS(0.285)ET(0.026)EEDT(0.001)VSVSK;SSLGQS(0.974)AS(0.009)ET(0.017)EEDT(0.001)VSVSK 214.94 2.6639e-17 15502000.0 4248.0 4580.9 4025.4 3833.6 3445.44 3996.1 4259.0 3293.0299999999997 2384.0499999999997 4150.5 True False 4346.97013483089 4044.5660983973644 3478.7727899394495 3164.1337255845465 3133.800560341838 3955.9028621684984 3937.740201059427 3205.688147131055 4045.558725877284 4683.257104293607 0.9281937843740398 0.8636224764788824 0.7428105509625156 0.6756267390666361 0.6691498012075339 0.8446905164659291 0.8408123050620708 0.6844997137125105 0.8638344288568566 1.0 12.19329652682198 -8.532300346312098 21.900377134385895 1.0000000038299792 0.7791644913141428 0.3925919968287981 0.08399007181650127 248.7833468098485 578295.9890740148 0.08696472804389462 0.02245419621676723 2.9356187552897103e-09 8.532300346312098 -0.22083551251583644 SSLGQS(ph)ASETEEDTVSVSK ddPTM_A459_Selumetinib_30min_R2 2 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.639)AS(0.36)ETEEDTVSVSK;S(0.004)S(0.004)LGQS(0.673)AS(0.317)ET(0.002)EEDTVSVSK 159.77 1.0304000000000003e-05 5555600.0 21491.7 18564.3 20934.0 28005.0 23273.4 21539.3 25935.0 20875.6 20902.8 20221.4 True False 20297.277352091707 19988.122116367227 19587.129231215837 24190.670688680373 20349.58742516416 24506.143060702216 27141.028889227575 20936.344539858375 25083.94407303021 19637.55564049312 1.033594899674694 1.017851838705996 0.9974321442953266 1.2318575250169435 1.0362586768794593 1.247922272473156 1.3820981280003153 1.06613801244627 1.277345537919521 1.0 14.261327742765918 -5.755823577303342 24.99672478835027 1.1857199017735283 1.0164488083335637 0.30211136451096965 0.11168950733589383 160.97460040654326 716510.1839694902 0.029989400525037027 0.050137413156663056 1.7545931224197613e-06 5.755823577303342 -0.1692710934399646 SSLGQS(ph)ASETEEDTVSVSKK ddPTM_A459_Selumetinib_30min_R1 1 SSLGQSASETEEDTVSVSKK 20 1 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 S(0.027)S(0.027)LGQS(0.897)AS(0.049)ET(0.001)EEDTVSVSKK 119.29 0.00013099 28599000.0 1721.8 1609.8 3312.3 3018.1 2541.5 2088.2 1962.3 1905.5 1366.4 1510.8 True False 1761.9145899604127 1421.3238676242827 2862.507853161534 2491.04549175363 2311.621773738268 2067.1946039338986 1814.2821311432072 1854.9599500636868 2318.681002092541 1704.7258964382079 1.0335471489238786 0.8337550749912024 1.6791601858940217 1.4612586674246748 1.3560078946228753 1.2126257999910834 1.0642661878568878 1.0881279822987218 1.3601488702301692 1.0 10.73532407104368 -7.002426962107329 18.765440529382253 1.1359032158942581 1.2817000817347373 0.07904409631879339 0.23111516883201558 11.89992421061845 92023.47018759671 0.08986662635425297 0.0772415682891284 9.944272986594493e-08 7.002426962107329 0.14579686584047913 SSLGQS(ph)ASETEEDTVSVSKK ddPTM_A459_Selumetinib_30min_R2 1 SSLGQSASETEEDTVSVSKK 20 1 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 S(0.007)S(0.007)LGQS(0.939)AS(0.045)ET(0.001)EEDTVSVSKK 108.13 0.00097791 0.0 31220.0 37041.0 35327.0 44648.0 35759.0 16702.0 24230.0 31092.0 22567.0 29196.0 True False 29484.91738356218 39881.92559441284 33054.099281129354 38566.86537790399 31266.634730483944 19002.548894339565 25356.743010834158 31182.472572442297 27081.030574663342 28353.035619681974 1.0399210080734524 1.4066192463260545 1.1658045975925069 1.3602376089540067 1.102761452067567 0.6702121476244494 0.8943219819902507 1.0997930870864563 0.9551369009625327 1.0 14.791215585228718 -6.526633204781256 24.996912686968635 0.9236378023722 1.2470731619676223 0.5441549417190474 0.1380998849004049 83.70034403825406 557263.4161999598 0.045312343399871696 0.04551192637321821 2.9741768932819055e-07 6.526633204781256 0.32343535959542236 SSLGQSAS(ph)ETEEDTVSVSK ddPTM_A459_Selumetinib_30min_R1 5 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.009)AS(0.672)ETEEDT(0.317)VSVSK;SSLGQSAS(0.489)ET(0.017)EEDT(0.489)VS(0.004)VSK;SSLGQS(0.074)AS(0.926)ETEEDTVSVSK;SSLGQS(0.024)AS(0.973)ETEEDT(0.002)VSVSK;SSLGQS(0.102)AS(0.883)ETEEDT(0.014)VSVSK 334.98 4.614299999999998e-155 95879600.0 18405.41 21569.15 15789.3 17973.000000000004 16338.41 16338.29 18121.24 16373.61 8427.38 15712.300000000001 True False 18834.220242306466 19043.823890774216 13645.199784416689 14834.352944994538 14860.603700280573 16173.94163658039 16754.340277305975 15939.3286738191 14300.648348517721 17729.12675576255 1.062332087855637 1.0741546469334338 0.7696487239554283 0.8367221436990903 0.838202800679418 0.9122807828830783 0.9450177951861201 0.899047589506251 0.8066188789512455 1.0 14.113833857909201 -5.2421229276428045 24.807458426446416 0.8733531176229263 1.0682434280263133 0.5892528978920871 0.06419201963460122 505.13985031072036 648731.2784996125 0.01649668727241029 0.0434936161816305 5.726339232349859e-06 5.2421229276428045 0.194890310403387 SSLGQSAS(ph)ETEEDTVSVSK ddPTM_A459_Selumetinib_30min_R2 7 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.003)AS(0.796)ETEEDT(0.201)VSVSK;S(0.019)S(0.004)LGQS(0.106)AS(0.871)ETEEDT(0.001)VSVSK;SSLGQS(0.009)AS(0.991)ETEEDTVSVSK;SSLGQS(0.06)AS(0.874)ET(0.052)EEDT(0.011)VS(0.002)VS(0.001)K;SSLGQS(0.134)AS(0.529)ETEEDT(0.314)VS(0.021)VS(0.001)K;SSLGQSAS(0.911)ET(0.002)EEDT(0.083)VS(0.003)VSK;SSLGQSAS(0.916)ET(0.002)EEDT(0.082)VSVSK 243.87 2.202199999999999e-79 66759000.0 412141.9 322299.3 372879.2 420073.6 400071.0 330281.8 405541.65 393053.7 327573.19999999995 336086.68 True False 389236.70313274604 347018.6199544108 348888.55823217623 362858.8510126207 349810.50429988065 375775.11995033483 424400.14029053494 394197.42119345715 393096.99315993855 326382.984290336 1.1925765798700403 1.0632252190136182 1.0689544952558563 1.1117578687553067 1.071779232181738 1.151331834186741 1.3003133150869384 1.2077756505921164 1.2044040654100296 1.0 18.316206319981987 -6.99792003478718 14.11274020549143 1.1997780807417011 1.0995896467370117 0.1545025423638624 0.07869747024371929 0.4016653094508718 2651.37924632635 0.02666654221441331 0.0230088249788016 1.004800783906268e-07 6.99792003478718 -0.10018843400468946 SSLGQSAS(ph)ETEEDTVSVSKK ddPTM_A459_Selumetinib_30min_R1 4 SSLGQSASETEEDTVSVSKK 20 1 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.048)AS(0.763)ET(0.137)EEDT(0.052)VS(0.001)VSKK;S(0.002)S(0.002)LGQS(0.323)AS(0.641)ET(0.028)EEDT(0.003)VSVSKK;SSLGQS(0.009)AS(0.99)ET(0.001)EEDTVSVSKK;S(0.001)S(0.001)LGQS(0.082)AS(0.82)ET(0.096)EEDTVSVSKK 182.62 7.3698e-14 116759000.0 9826.1 10375.6 17538.8 16750.1 14339.1 11657.6 10946.8 10993.400000000001 6557.460000000001 9339.699999999999 True False 10055.029011737724 9160.819928514426 15157.127293732305 13825.009473318465 13042.13093677372 11540.33512825392 10121.074062680758 10701.819320404175 11127.53068207095 10538.541471381994 0.9541196036512951 0.8692682904357449 1.4382566444220335 1.3118522625603422 1.2375650816757104 1.0950599909477374 0.960386604746502 1.0154934010048327 1.0558890632340718 1.0 13.363387592102528 -7.012896514722111 5.755229602321314 1.0108801645737808 1.1697383633563359 0.18049253609874272 0.1544160179651223 0.3277333277741295 38.92496274573944 0.06428744921673225 0.05262087705480003 9.707412514653469e-08 7.012896514722111 0.15885819878255503 SSLGQSAS(ph)ETEEDTVSVSKK ddPTM_A459_Selumetinib_30min_R2 1 SSLGQSASETEEDTVSVSKK 20 1 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.019)AS(0.961)ET(0.019)EEDTVSVSKK 135.12 5.8498e-05 22864000.0 37981.0 38843.0 35576.0 48166.0 33511.0 22654.0 25106.0 27364.0 17190.0 33400.0 True False 35870.168069989566 41822.13320006957 33287.07889222008 41605.70770901553 29301.048587858906 25774.382867463097 26273.478746595232 27443.624709645937 20628.48032873058 32435.655216378207 1.1058869577537351 1.2893876482862512 1.0262496216019694 1.282715192015204 0.9033592320670465 0.7946311765716533 0.8100184371588888 0.8460943528524261 0.635981613169767 1.0 14.98529296181791 -6.417346080116349 4.413772682552663 0.8104293467839861 1.1720908739815 0.7055841525316309 0.10987309001246776 0.11858834684806357 3.836592002554682 0.03287193111267512 0.03712562843995807 3.8251979986765034e-07 6.417346080116349 0.36166152719751377 SSLGQSASET(ph)EEDTVSVSK ddPTM_A459_Selumetinib_30min_R1 1 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.011)AS(0.288)ET(0.604)EEDT(0.097)VSVSK 195.46 7.94e-15 8238300.0 1300.8 1313.8 1105.0 1101.6 1095.4 1057.7 1240.8 995.92 735.49 1046.0 True False 1331.1061090838098 1159.979685230951 954.9470693305242 909.2262395930547 996.3212634085771 1047.0604983147612 1147.205457026189 969.5049663959206 1248.0728119357739 1180.2642889028102 1.1278034264014072 0.9828135072266602 0.809095961225986 0.7703581715907747 0.8441509861615579 0.8871407092119367 0.9719903142139857 0.8214303995397384 1.0574519822979642 1.0 10.20489423373781 -9.58774872992393 12.620774679193179 0.9999999938754773 0.908931953610575 0.039315319761641154 0.10995255058852267 0.0 0.0 0.1103299696978512 0.02675894816090802 2.58375464308348e-10 9.58774872992393 -0.09106804026490234 SSLGQSASETEEDT(ph)VSVSK ddPTM_A459_Selumetinib_30min_R1 1 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQS(0.074)AS(0.086)ET(0.002)EEDT(0.836)VS(0.002)VSK 169.06 1.0868e-08 11599000.0 3219.2 3272.7 3686.4 3239.4 2966.6 3165.2 2954.5 2999.9 1784.9 2986.9 True False 3294.201096527215 2889.530762563048 3185.8071279457436 2673.6996010691187 2698.27155379577 3133.360961771659 2731.6396863184045 2920.332906951486 3028.8449360618965 3370.2977098697916 0.9774213971900078 0.857351786490898 0.9452598560110064 0.7933125887482547 0.8006033253068363 0.929698570128012 0.810503973675352 0.8664910813069717 0.8986876521893116 1.0 11.718660319862222 -10.313965114989399 9.50507880469759 1.000001299549979 0.8718003492590376 0.2784138797224187 0.05987551725055979 0.0 0.0 0.05712126249110456 0.013853941101144488 4.853274828688446e-11 10.313965114989399 -0.12820095029094136 SSLGQSASETEEDT(ph)VSVSK ddPTM_A459_Selumetinib_30min_R2 4 SSLGQSASETEEDTVSVSK 19 0 E9PPJ0;Q13435;E9PJ04;H0YCG1 E9PPJ0 SF3B2 Splicing factor 3B subunit 2 1 SSLGQSAS(0.3)ET(0.002)EEDT(0.692)VS(0.002)VS(0.004)K;SSLGQSAS(0.339)ET(0.005)EEDT(0.648)VS(0.007)VSK;SSLGQS(0.018)AS(0.239)ETEEDT(0.736)VS(0.007)VS(0.001)K;SSLGQSAS(0.082)ET(0.002)EEDT(0.915)VS(0.001)VSK 205.98 6.257500000000002e-16 93160800.0 387881.0 341185.0 389119.0 414862.0 400936.0 339801.0 337966.0 352929.0 314903.0 342310.0 True False 366324.1268306683 367352.792417315 364083.5071807342 358357.07992313185 350566.83526668267 386605.50334364077 353682.08866692404 353955.9649594585 377892.3991249701 332426.6208718096 1.1019698899864288 1.1050643039775494 1.0952296967851203 1.0780035575469797 1.0545690785752935 1.1629799753393506 1.0639403298669963 1.064764199783961 1.1367693662256158 1.0 18.342676392832452 -11.056191222611238 3.2932572332727994 0.9972642100734299 1.094541833411324 0.4444865699773579 0.0321369113049808 10615507.20780315 652.0076606391617 221021.69914362958 0.007759177917126013 8.78635562844322e-12 11.056191222611238 0.09727762333789403 SSLGSLQT(ph)PEAVTTR ddPTM_A459_Selumetinib_30min_R1 4 SSLGSLQTPEAVTTR 15 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 SSLGS(0.155)LQT(0.844)PEAVT(0.001)TR;SSLGS(0.149)LQT(0.809)PEAVT(0.039)T(0.003)R;S(0.036)S(0.014)LGS(0.038)LQT(0.904)PEAVT(0.007)T(0.001)R;SSLGS(0.009)LQT(0.99)PEAVTTR 228.32 2.1876999999999999e-13 50449000.0 7020.299999999999 8237.3 8463.6 8667.3 8467.4 7315.299999999999 8169.5 7138.3 4029.3900000000003 6653.7 True False 7183.859330874131 7272.873086583125 7314.2896072269905 7153.718760371169 7701.5251650408845 7241.714723760966 7553.268037697812 6948.969095533782 6837.580534998291 7507.767207526414 0.956856963235678 0.968713185365176 0.974229675088292 0.9528423781173827 1.0258076672010064 0.9645630349994424 1.0060605009337242 0.9255706661452627 0.9107342231048039 1.0 12.874168202045318 -10.567171235474344 4.7209949573468535 1.0000010190587563 0.9668800585413789 0.0946740984617892 0.031979142566472975 3.54000265547779e-07 7.161653617184349e-08 0.03195619204781833 0.007750276522808691 2.709123256649842e-11 10.567171235474344 -0.03312096051737734 SSLGSLQT(ph)PEAVTTR ddPTM_A459_Selumetinib_30min_R2 1 SSLGSLQTPEAVTTR 15 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 SSLGS(0.042)LQT(0.956)PEAVT(0.002)TR 108.06 0.009553399999999998 17578000.0 34577.0 27862.0 31112.0 40335.0 39350.0 33845.0 29522.0 32534.0 29030.0 35928.0 True False 32655.348762697926 29998.92580954968 29110.287792184354 34841.303418244024 34406.5012065366 38506.84153567971 30894.83149673323 32628.668553706346 34836.811165971434 34890.665287845375 0.9359336800629551 0.8597980451808754 0.8343288255476546 0.9985852413763361 0.9861233921074747 1.1036430867110487 0.8854755632159257 0.9351689996313419 0.9984564891087732 1.0 15.090553486348705 -5.770096592275619 24.999997891635704 0.9846987355799626 0.8749979666979064 0.43759136293022605 0.05715124641188264 176.87412454476853 510771.68018174055 0.01675109097268782 0.025283008551685148 1.6978659848071535e-06 5.770096592275619 -0.10970076888205615 SSLGSLQTPEAVT(ph)TR ddPTM_A459_Selumetinib_30min_R2 1 SSLGSLQTPEAVTTR 15 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 S(0.002)SLGS(0.01)LQT(0.258)PEAVT(0.706)T(0.024)R 199.61 5.0323e-05 16710000.0 24453.0 26613.0 29987.0 32784.0 34283.0 23773.0 28740.0 24312.0 21596.0 29855.0 True False 23094.000153114863 28654.131525717687 28057.669067376974 28318.762644445538 29976.06304609134 27047.51496019248 30076.466947229626 24382.743894931747 25915.803442656506 28993.00857739434 0.7965368647916417 0.9883117665842767 0.9677391358844131 0.9767445337330564 1.0339066042791945 0.9328978359728163 1.0373696426482644 0.8409870203654137 0.8938638904436738 1.0 14.82341742783239 -4.7560240850062545 24.967973794263035 0.9626595684693688 0.7965365987931877 0.42930456429066066 0.057755595869887696 174.07620805115283 802515.6260756914 0.014810172999358745 0.12451223318830072 1.753783238226154e-05 4.7560240850062545 -0.16612296967618112 SSLPLDHGSPAQENPESEKS(ph)SPAVSR ddPTM_A459_Selumetinib_30min_R2 1 SSLPLDHGSPAQENPESEKSSPAVSR 26 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 SSLPLDHGS(0.002)PAQENPES(0.147)EKS(0.412)S(0.412)PAVS(0.026)R 42.106 0.036275 7682900.0 9119.0 7857.5 21280.0 27288.0 39787.0 20719.0 11752.0 16377.0 18917.0 27365.0 True False 8612.202486249302 8460.144984155364 19910.867967912167 23571.32732557438 34788.601359707034 23572.85418164421 12298.491286146227 16424.654358641696 22700.9285851423 26574.901347191317 0.32407279235900227 0.3183509460158169 0.749235818706681 0.8869770396368986 1.3090773472761665 0.8870344944530004 0.4627859620425664 0.6180513765247752 0.854224378429971 1.0 14.697776715663984 -5.3158197862744885 3.5976820145173187 0.8454460826333454 0.30999454114833613 0.503683569278744 0.2102066636717681 0.2115921541146364 5.529651851201581 0.0637662549059376 0.1578283349196356 4.83259292477252e-06 5.3158197862744885 -0.5354515414850093 SSLPLDHGSPAQENPESEKSS(ph)PAVSR ddPTM_A459_Selumetinib_30min_R2 1 SSLPLDHGSPAQENPESEKSSPAVSR 26 1 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 SSLPLDHGSPAQENPES(0.026)EKS(0.266)S(0.704)PAVS(0.003)R 81.808 0.003421 0.0 3512.8 3855.6 6816.8 9912.8 7537.6 8190.2 4676.6 4944.3 5384.6 7586.6 True False 3317.5726388525695 4151.312122292003 6378.214509570661 8562.659539466193 6590.6593010010265 9318.32570676685 4894.071166507101 4958.687094427074 6461.670458294511 7367.555145645958 0.45029491782130365 0.563458574822521 0.8657165618013769 1.1622118016349714 0.8945517435177859 1.2647785489971863 0.6642734353199075 0.673043770477583 0.8770440574324303 1.0 12.846970238525405 -5.231387469205219 3.3676974948093727 0.9270024636059712 0.478061817998373 0.47827283139720134 0.1772144966161029 0.222170610545931 5.214891765107568 0.05030869010720296 0.1485655662823896 5.869654395471936e-06 5.231387469205219 -0.44894064560759817 SSLPPNS(ph)PKPVR ddPTM_A459_Selumetinib_30min_R2 1 SSLPPNSPKPVR 12 1 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 S(0.062)S(0.062)LPPNS(0.875)PKPVR 65.038 0.043729 5335700.0 15118.0 13735.0 15665.0 14730.0 14370.0 13081.0 9894.0 10449.0 7885.5 11241.0 True False 14277.802082149039 14788.43033501417 14657.130954762399 12723.748589332696 12564.71213057005 14882.789012504847 10354.090604589072 10479.404860074925 9462.82033927894 10916.443122374469 1.307917049728871 1.3546931147109293 1.3426654442710348 1.165558089452594 1.1509895658978215 1.363336834687565 0.948485737388876 0.9599651408979739 0.8668409877832673 1.0 13.414215242619402 -7.271771053082229 24.606176675773455 0.9404866872021316 1.275881204067644 0.8281710046224493 0.07518262601204212 248.24359176504714 591220.5394128936 0.03363787667734917 0.02296731514662349 5.3484623985489e-08 7.271771053082229 0.33539451686551236 SSLS(ph)GDEEDELFK ddPTM_A459_Selumetinib_30min_R1 3 SSLSGDEEDELFK 13 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 1 SSLS(1)GDEEDELFK;S(0.009)S(0.009)LS(0.981)GDEEDELFK;SS(0.001)LS(0.999)GDEEDELFK 206.66 1.2026e-05 15337900.0 4884.200000000001 5500.27 5724.0 5728.85 5053.0 5183.23 5400.17 4686.29 3214.84 4307.51 True False 4997.992357001188 4856.295831393849 4946.712239681375 4728.413891333219 4595.957042179605 5131.091412196297 4992.830829198189 4561.9943659847595 5455.348677376452 4860.420867200515 1.02830443979225 0.9991513006960975 1.0177538889817501 0.9728404227794106 0.9455882870544018 1.055688705235866 1.0272424889974474 0.938600687189535 1.1224025298283686 1.0 12.2468655278623 -6.782343334799195 24.999412713449708 1.0248528832239687 0.9933700016582135 0.12079073795896356 0.04804432852038059 623.177325762354 745263.6578892856 0.01657854880032788 0.014634917575476317 1.6506563433767686e-07 6.782343334799195 -0.03148288156575518 SSLS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 SSLSPGR 7 0 Q9BUQ8;F8W1J5;F8VVA2 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 1 SSLS(1)PGR 111.46 0.027687 46872000.0 24737.0 19824.0 19723.0 24715.0 24550.0 17484.0 21931.0 28883.0 22071.0 31814.0 True False 23362.216570056917 21344.43705579332 18454.043652778735 21348.77436424694 21465.809520215345 19892.262296050358 22950.83495545207 28967.044748161963 26485.81671526543 30895.447157301063 0.756170203690872 0.6908602729431383 0.5973062490023797 0.6910006595972474 0.6947887632415332 0.6438574005668506 0.742854920940299 0.9375829584430083 0.8572724835609453 1.0 14.915106633616753 -7.660183787066558 3.57975140792982 0.9253189313521237 0.6777375388761006 0.8337163750070666 0.05038085774801375 0.09086402274609416 2.2397677014610773 0.026551791600660825 0.013964175473565474 2.186835991130637e-08 7.660183787066558 -0.24758139247602318 SSLS(ph)PTMRPGTGAER ddPTM_A459_Selumetinib_30min_R2 1 SSLSPTMRPGTGAER 15 1 O75400-2;H7BXZ7;H7C2N3;O75400-5 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 SSLS(0.736)PT(0.204)MRPGT(0.06)GAER 110.57 0.019153 0.0 30564.0 27563.0 34628.0 31257.0 32420.0 23924.0 19976.0 22036.0 19705.0 28476.0 True False 28865.37523738609 29676.99347098624 32400.0721801157 26999.742678667488 28347.10976152268 27219.31383955095 20904.923581693067 22100.121111743818 23646.550603701937 27653.823890466625 1.0438113496244958 1.0731605722424913 1.1716308134617612 0.976347531018138 1.0250701629475212 0.9842875237566885 0.7559505573079109 0.7991705306029164 0.8550915308263696 1.0 14.755191365484237 -7.030627054843812 3.323808532271446 0.8363649110927125 1.0595865291469198 0.6165738849234852 0.07561063686110807 0.15452047802861715 3.499383296343741 0.03004774168872642 0.023946919544778657 9.319077965548318e-08 7.030627054843812 0.22322161805420726 SSLSNNECGSLDKT(ph)SPEMSNSNNDER ddPTM_A459_Selumetinib_30min_R1 3 SSLSNNECGSLDKTSPEMSNSNNDER 26 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SSLSNNECGS(0.035)LDKT(0.85)S(0.111)PEMS(0.003)NSNNDER;SSLSNNECGSLDKT(0.989)S(0.011)PEMSNSNNDER;SSLSNNECGS(0.004)LDKT(0.446)S(0.446)PEMS(0.084)NS(0.02)NNDER 128.51 9.0908e-09 47267000.0 2977.6399999999994 4584.09 4325.59 4345.04 3840.3599999999997 4275.77 4006.85 3504.27 1667.87 2862.63 True False 3047.0132185211523 4047.382611714374 3738.1986367650875 3586.2603305023667 3493.0001160706247 4232.759635888541 3704.6100785665594 3411.3253761268306 2830.2535735949073 3230.076444877487 0.9433254198529415 1.2530299764679056 1.1573096490311927 1.1102710389996324 1.0813985909250237 1.3104208857351314 1.1469109607116654 1.0561128921690948 0.8762187588728276 1.0 11.65735259364958 -8.000052065110099 3.5467027865465637 0.9402615447508711 1.1500075160743177 0.4141702310988784 0.09674309940681632 0.2155254612153533 5.687366839817121 0.06586105919191326 0.025183192068374657 9.998801228394624e-09 8.000052065110099 0.20974597132344663 SSLSNNECGSLDKT(ph)SPEMSNSNNDER ddPTM_A459_Selumetinib_30min_R2 2 SSLSNNECGSLDKTSPEMSNSNNDER 26 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SSLSNNECGS(0.051)LDKT(0.698)S(0.244)PEMS(0.007)NSNNDER;SSLSNNECGSLDKT(0.749)S(0.25)PEMS(0.001)NSNNDER 143.0 1.4246e-09 31241000.0 65962.0 54915.0 62150.0 70317.0 85351.0 48277.0 53253.0 61327.0 46292.0 60322.0 True False 62296.09610680748 59126.80392044437 58151.3366638036 60739.7032964092 74628.44433237879 54926.71853502762 55729.3700188176 61505.45141676861 55551.69350655012 58580.34712462176 1.0634299584172995 1.0093283297666382 0.9926765462842769 1.03686144377386 1.2739501897046952 0.9376304721817107 0.9513321916693479 1.049933201760039 0.9482991520752072 1.0 15.838129121648372 SSLSNNECGSLDKTS(ph)PEMSNSNNDER ddPTM_A459_Selumetinib_30min_R2 2 SSLSNNECGSLDKTSPEMSNSNNDER 26 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SSLS(0.002)NNECGS(0.03)LDKT(0.192)S(0.755)PEMS(0.02)NS(0.001)NNDER;SSLSNNECGS(0.011)LDKT(0.198)S(0.68)PEMS(0.072)NS(0.039)NNDER 82.294 6.6899e-05 18282500.0 25907.0 20644.4 27121.0 26355.0 28490.0 19856.0 24371.0 23330.0 21915.0 24230.0 True False 24467.192653938007 22227.759097791528 25376.064387112117 22765.403535089154 24910.831496168434 22590.983765178218 25504.29979022034 23397.88643751059 26298.612356261245 23530.416942899523 1.0398112669788948 0.9446394065915147 1.0784366655589388 0.9674883190694494 1.0586651123360338 0.9600757955117839 1.083886437376387 0.9943676941334895 1.1176432793383648 1.0 14.522239263907842 -7.273780791688212 24.968541609563587 1.0485049885006095 1.008935416223636 0.12542717200780884 0.052736532627723 1627.174091835482 3292006.0534551125 0.020030548785694286 0.01364622510430516 5.32376906464574e-08 7.273780791688212 -0.03956957227697355 SSLSNNECGSLDKTSPEMS(ph)NSNNDER ddPTM_A459_Selumetinib_30min_R1 1 SSLSNNECGSLDKTSPEMSNSNNDER 26 1 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SSLSNNECGS(0.004)LDKT(0.115)S(0.342)PEMS(0.521)NS(0.019)NNDER 78.736 0.00029783 4397900.0 334.73 696.96 798.5 799.75 802.33 726.85 665.99 450.54 436.41 458.45 True False 342.52855772880054 615.3595991920862 690.0680858465374 660.088675666799 729.7593931628667 719.5385489269967 615.7538381083751 438.59021563982856 740.5558958747115 517.2965231811595 0.6621512853447993 1.189568403452394 1.3339894140461341 1.2760353995954328 1.410717761401427 1.3909595689956167 1.1903305174404497 0.8478506929501097 1.4315887748879488 1.0 9.01484768480343 -4.764473365957158 4.586428609393575 1.2427313719787292 0.6171457969735041 0.4823847457930782 0.1769053655734094 0.17101757380837024 8.188485380930581 0.04495018018160003 0.35149608459360776 1.719992820261557e-05 4.764473365957158 -0.625585575005225 SSLSS(ph)LSPPSSPLDTPFLPASR ddPTM_A459_Selumetinib_30min_R2 1 SSLSSLSPPSSPLDTPFLPASR 22 0 Q9ULE0;Q9ULE0-2 Q9ULE0 WWC3 Protein WWC3 1 SSLS(0.006)S(0.874)LS(0.117)PPS(0.002)S(0.001)PLDTPFLPASR 162.09 2.701e-12 0.0 7611.8 8128.2 7843.7 7882.9 7998.4 5611.0 4779.1 7801.4 3868.9 3852.7 True False 7188.766628449664 8751.60680371767 7339.044881574844 6809.235421239013 6993.569485396761 6383.864318413325 5001.337619606996 7824.100782408708 4642.788106098066 3741.4625404832445 1.9213787524707298 2.339087110728448 1.9615443966537585 1.819939488251441 1.8692074047849419 1.706248358586744 1.3367333136418431 2.091187790269351 1.2409019349685664 1.0 11.869386615590043 -8.027676795913148 0.09268705487849863 1.2198717102118002e-13 3.1481009434060154 0.6363831307973556 0.2371334912816585 7.139306388940458 0.6726204717654449 10.86025085688416 10.515066875641569 9.3826000487163e-09 8.027676795913148 3.1481009434058933 SSLSSLS(ph)PPSSPLDTPFLPASR ddPTM_A459_Selumetinib_30min_R1 2 SSLSSLSPPSSPLDTPFLPASR 22 0 Q9ULE0;Q9ULE0-2 Q9ULE0 WWC3 Protein WWC3 1 SSLS(0.003)S(0.049)LS(0.948)PPSSPLDTPFLPASR;SSLS(0.002)S(0.005)LS(0.956)PPS(0.013)S(0.024)PLDTPFLPASR 148.19 3.7229e-08 0.0 1264.97 1256.9099999999999 1354.74 1562.91 1515.42 1121.05 1071.15 1072.62 667.6800000000001 1162.23 True False 1294.4413397968533 1109.750392878393 1170.7737490541485 1289.9771079542315 1378.3505285691322 1109.7732548319593 990.352293112187 1044.1706332392084 1133.0041945822206 1311.4135415788842 0.9870580856122645 0.8462245948309353 0.8927570990647149 0.9836539482436302 1.0510418604566634 0.8462420278929262 0.7551792487363265 0.7962176690520314 0.8639564551225645 1.0 10.356906981897483 -6.966275307621513 24.67579134259815 0.8316927602072953 0.9451064078011582 0.26387401542193234 0.07966637423838854 197.36018757303773 144404.45241729933 0.028459188978453703 0.02509849990483634 1.0807486267684841e-07 6.966275307621513 0.11341364759386285 SSLSSLS(ph)PPSSPLDTPFLPASR ddPTM_A459_Selumetinib_30min_R2 1 SSLSSLSPPSSPLDTPFLPASR 22 0 Q9ULE0;Q9ULE0-2 Q9ULE0 WWC3 Protein WWC3 1 SSLS(0.001)S(0.018)LS(0.979)PPS(0.001)SPLDTPFLPASR 159.5 3.3721e-11 0.0 5722.5 6476.0 5439.9 7109.0 7191.7 5256.1 4506.8 4491.8 4284.0 3517.2 True False 5404.466358982524 6972.688376378004 5089.902756515291 6140.7419362909795 6288.214351386265 5980.080064874757 4716.375130054783 4504.870394342478 5140.919704961132 3415.6492972169276 1.5822661780253862 2.041394701165413 1.49017135941402 1.797825655372306 1.8410011696780182 1.7507886625677083 1.3808136373654307 1.3188913738928199 1.5051075967166638 1.0 11.737944138092468 -8.118050253603476 0.547195415526159 1.023026754345232 1.789782785336921 0.6326773281516727 0.17299259475297135 0.5096538661626718 0.3676879718595412 0.17647151171242692 0.0944864664190055 7.619908325276039e-09 8.118050253603476 0.766756030991689 SSLST(ph)SSPESAR ddPTM_A459_Selumetinib_30min_R2 1 SSLSTSSPESAR 12 0 Q8N7B6;D6RF51;D6RGK2;D6RAM4;D6RC23;D6R9D1;D6REJ6;D6RF67;D6RF08;D6RBZ2;D6RDH3;D6REQ4;D6R9F1;D6RB63;D6RC13;Q8N7B6-2;Q8N7B6-3;Q8N7B6-4;D6R9N9 Q8N7B6 PACRGL PACRG-like protein 1 SSLS(0.018)T(0.383)S(0.383)S(0.215)PESAR 155.47 0.00099698 19303000.0 60960.0 63027.0 64060.0 69920.0 74437.0 55523.0 52416.0 42970.0 48792.0 65798.0 True False 57572.08724221493 67860.96823625329 59938.44934325433 60396.775381272295 65085.55858477684 63170.78926238867 54853.44786033358 43095.03558593357 58551.76336238638 63898.24077626501 0.9009964365654347 1.0620162216024613 0.938029726876588 0.9452024758044147 1.0185813849346672 0.9886154688292053 0.8584500479817416 0.6744322701594816 0.9163282533458327 1.0 15.96348859149956 -7.3133420393250415 5.279133470217547 0.8329742778935187 0.9784533032656455 0.2623498081982403 0.08816162298568406 0.22203812837077902 14.110629112189306 0.03570870505957433 0.02406554190202402 4.8602427451940254e-08 7.3133420393250415 0.14547902537212676 SSLSTSS(ph)PESAR ddPTM_A459_Selumetinib_30min_R1 2 SSLSTSSPESAR 12 0 Q8N7B6;D6RF51;D6RGK2;D6RAM4;D6RC23;D6R9D1;D6REJ6;D6RF67;D6RF08;D6RBZ2;D6RDH3;D6REQ4;D6R9F1;D6RB63;D6RC13;Q8N7B6-2;Q8N7B6-3;Q8N7B6-4;D6R9N9 Q8N7B6 PACRGL PACRG-like protein 1 SSLST(0.003)S(0.018)S(0.979)PESAR;SSLS(0.004)T(0.32)S(0.153)S(0.523)PESAR 239.48 2.77e-13 47334000.0 8702.8 10137.2 10660.8 11501.8 10583.5 9060.1 9746.900000000001 8655.6 5030.6 7486.700000000001 True False 8905.55830729903 8950.33191134358 9213.12191558267 9493.226545525964 9626.224293668689 8968.963619912613 9011.683485725789 8426.025370648782 8536.560779513118 8447.69087163352 1.054200306642728 1.0595004063652325 1.090608315997853 1.1237658538622957 1.1395095346105246 1.0617059449972859 1.0667629323400194 0.9974353345412427 1.0105200236644565 1.0 13.044341327440709 -7.592800448632572 2.039629305204417 1.0005266396817116 1.0915319397890897 0.6771242948019521 0.026266497909314453 0.21511485817542533 1.7755566696016032 0.01829393602725309 0.008840413531903433 2.5538744975881292e-08 7.592800448632572 0.09100530010737806 SSLSTSS(ph)PESAR ddPTM_A459_Selumetinib_30min_R2 1 SSLSTSSPESAR 12 0 Q8N7B6;D6RF51;D6RGK2;D6RAM4;D6RC23;D6R9D1;D6REJ6;D6RF67;D6RF08;D6RBZ2;D6RDH3;D6REQ4;D6R9F1;D6RB63;D6RC13;Q8N7B6-2;Q8N7B6-3;Q8N7B6-4;D6R9N9 Q8N7B6 PACRGL PACRG-like protein 1 SSLS(0.009)T(0.198)S(0.111)S(0.682)PESAR 166.24 0.00047855 14728000.0 52601.0 50054.0 57768.0 59107.0 59170.0 47540.0 39185.0 48158.0 40937.0 57852.0 True False 49677.646998486656 53892.98085102289 54051.269773042724 51056.52463473778 51736.53561348851 54088.20347484752 41007.180143604455 48298.131807013895 49125.54387534869 56181.66244245245 0.8842324139014588 0.9592628360940034 0.9620802842637148 0.9087756113845081 0.920879400222143 0.9627376820728777 0.72990328802763 0.8596778683166638 0.8744053084165776 1.0 15.77781169468654 SSLVNESETNQNSS(ph)SDSEAER ddPTM_A459_Selumetinib_30min_R2 1 SSLVNESETNQNSSSDSEAER 21 0 Q9NQB0;Q5VVR7;E2GH26;C6ZRJ7;A0A0D9SGH8;C6ZRK5;Q9NQB0-13;Q9NQB0-3;Q9NQB0-7;Q9NQB0-5;Q9NQB0-8;Q9NQB0-16;Q9NQB0-2;Q9NQB0-14;Q9NQB0-6;Q9NQB0-4;Q9NQB0-9;Q9NQB0-12;Q9NQB0-10;Q9NQB0-15;Q9NQB0-11;A0A0A0MTL7 Q9NQB0 TCF7L2 Transcription factor 7-like 2 1 SSLVNESETNQNS(0.002)S(0.499)S(0.499)DSEAER 202.21 7.48e-17 7445300.0 48648.0 42829.0 58405.0 59467.0 68086.0 49235.0 44014.0 43469.0 42974.0 54488.0 True False 45944.3389133739 46113.8465830595 54647.285886555896 51367.49201370316 59532.42798343712 56016.674339169535 46060.73821208645 43595.48759331966 51570.0007938841 52914.78986317413 0.868270270602524 0.87147367876353 1.0327412435703065 0.9707586885732338 1.1250621638557903 1.058620368407702 0.8704700204080801 0.8238809547585446 0.9745857618868495 1.0 15.691383396407849 -10.53572827629484 12.538681738387684 0.9999999997844176 0.9570763694517296 0.02045689778260129 0.09230676613159952 0.0 0.0 0.0988225761697417 0.02396799527902893 2.912538827408901e-11 10.53572827629484 -0.04292363033268798 SSMNNGS(ph)PTALSGSK ddPTM_A459_Selumetinib_30min_R2 1 SSMNNGSPTALSGSK 15 0 D6RCP5;Q8N264-3;Q8N264-2;Q8N264 D6RCP5 ARHGAP24 Rho GTPase-activating protein 24 1 SSMNNGS(0.494)PT(0.494)ALS(0.011)GSK 98.077 0.014882 0.0 14978.0 13887.0 13131.0 13251.0 18006.0 12345.0 11411.0 12502.0 8814.2 14861.0 True False 14145.582721684628 14952.088246257155 12286.165755951813 11446.19094075 15743.925304317621 14045.411693247635 11941.634110467534 12538.378750182479 10577.286289325017 14431.924316484921 0.9801591535182028 1.0360425899114558 0.8513186105000491 0.7931160592129454 1.0909096360998831 0.9732182199157052 0.827445727166623 0.8687946579556592 0.7329089355910127 1.0 13.816976057532115 -7.262174967745406 24.94248680237574 0.8463535493551055 0.9520763511287207 0.17988253424114165 0.10015944948464531 111.39129425011437 3776965.7348338505 0.04116925493983221 0.029625061959854742 5.467956265172908e-08 7.262174967745406 0.10572280177361515 SSMS(ph)GLHLVK ddPTM_A459_Selumetinib_30min_R2 1 SSMSGLHLVK 10 0 Q13085;A0A0C4DGT1;Q13085-4;Q13085-2 Q13085 ACACA Acetyl-CoA carboxylase 1;Biotin carboxylase 1 S(0.001)S(0.002)MS(0.998)GLHLVK 128.08 0.0031781999999999995 7736100.0 25395.0 17080.0 37406.0 37069.0 36536.0 22813.0 23771.0 25975.0 20464.0 24440.0 True False 23983.647564239618 18389.981079143945 34999.338684573406 32020.138252408255 31946.0210440158 25955.28367420481 24876.398601342906 26050.582949607273 24557.371811933837 23734.35369725399 1.0105035034939447 0.774825441371577 1.4746278382386602 1.3491051267224061 1.345982344895782 1.093574487229782 1.0481178008323457 1.0975897335102605 1.0346762387203772 1.0 14.534689144275225 -6.982716282943639 24.820508250546094 1.0557452017966447 1.195162424284715 0.12287851437101494 0.18457751453688784 566.8616574683115 814045.9724094096 0.07204777544988887 0.06352654913123756 1.040599749601948e-07 6.982716282943639 0.1394172224880703 SSPAPSENTHIS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 SSPAPSENTHISPLK 15 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 SSPAPSENT(0.001)HIS(0.999)PLK 128.06 0.0010024 2537600.0 9216.8 9099.8 11275.0 9161.7 10815.0 9458.9 8024.2 8396.9 8023.1 10781.0 True False 8704.567153773723 9797.72539953127 10549.578775291804 7913.8606551859675 9456.323012673283 10761.77761565493 8397.341199650651 8421.333588818372 9627.944184144175 10469.724517598002 0.8314036476454256 0.9358150143361265 1.0076271593927404 0.7558805049630466 0.9032064785256435 1.02789501266877 0.802059422436188 0.8043510194239973 0.9195986167507155 1.0 13.353935861710825 SSPASSQEGSPSGDQQFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SSPASSQEGSPSGDQQFSPK 20 0 Q6ZW49-1;Q6ZW49 Q6ZW49-1 PAXIP1 PAX-interacting protein 1 1 SSPASSQEGSPSGDQQFS(1)PK 239.19 1.7357999999999995e-67 0.0 14292.0 12201.0 13204.0 13833.0 10917.0 10457.0 10903.0 13600.0 7852.9 11853.0 True False 13497.70785540904 13136.7774676016 12354.469015428203 11948.921536744001 9545.508860781714 11897.356830805233 11410.01110388464 13639.5737483988 9423.69942835883 11510.773092207506 1.1726152315995733 1.1412593543777574 1.0732961996959056 1.038064206550393 0.8292673988373357 1.0335845156099406 0.9912462883669317 1.1849398506198021 0.818685187595126 1.0 13.49069711126796 -5.532488104389698 1.985059687308991 0.9873672707965534 1.161401482124603 0.3381727883085459 0.09829786829139828 0.41293415999291383 3.1894232078717377 0.02862618001750603 0.07393865381400343 2.9343498766202196e-06 5.532488104389698 0.17403421132804964 SSPGAVAGLSNAPGT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SSPGAVAGLSNAPGTPR 17 0 Q9BWG4-2;Q9BWG4;V9GYB2;U3KPY3 Q9BWG4-2;U3KPY3 SSBP4 Single-stranded DNA-binding protein 4 1 SSPGAVAGLSNAPGT(1)PR;SSPGAVAGLSNAPGT(1)PR 223.93 5.3679e-12 18064800.0 2958.4 2977.3999999999996 3053.3 3292.2 2925.1 2736.8999999999996 3238.2 2825.1000000000004 1841.7199999999998 2614.74 True False 3027.3249639556775 2628.804623844293 2638.6786305763726 2717.2790722478703 2660.52522146835 2709.3692709063716 2993.9399669102213 2750.169170781908 3125.26432609329 2950.367348724408 1.0260840790773196 0.8910092585524502 0.8943559627302701 0.9209968627881834 0.9017606646910015 0.9183159080437112 1.0147685399937239 0.9321446605525052 1.0592797291647424 1.0 11.52667887953939 -7.253532189612648 23.92435554261504 0.9958936214856249 0.9211677651538817 0.3890004485488874 0.046341659425676314 347.8056371391237 1052339.4869211246 0.017338390512657946 0.013171387926514198 5.5778625786963093e-08 7.253532189612648 -0.07472585633174322 SSPGAVAGLSNAPGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 SSPGAVAGLSNAPGTPR 17 0 Q9BWG4-2;Q9BWG4;V9GYB2;U3KPY3 Q9BWG4-2;U3KPY3 SSBP4 Single-stranded DNA-binding protein 4 1 SSPGAVAGLSNAPGT(1)PR;SSPGAVAGLSNAPGT(1)PR;SSPGAVAGLSNAPGT(1)PR 214.34 2.3226e-09 29334500.0 36210.7 31174.1 33012.0 40210.0 40039.0 25733.3 32507.8 33363.9 29719.399999999998 31412.6 True False 34198.254256917164 33565.05322946966 30888.04386074793 34733.328633881014 35008.94286679847 29277.828491360826 34019.477112983695 33460.98342530901 35664.11042941685 30505.636618263525 1.1210470604125302 1.1002902070030718 1.0125356257032008 1.1385872410571625 1.1476221035767156 0.9597514340622672 1.1151865977652293 1.0968787127450452 1.1690990381779143 1.0 14.896788217959076 -10.922706482888739 4.820190105323004 0.999881309170991 1.0927601759830186 0.18296841214293436 0.06036690542482768 7.666245264416395e-05 9.545409685772453e-06 0.05819494585212992 0.014096334883556244 1.1947953318366897e-11 10.922706482888739 0.0928788668120275 SSPGLYTSPGQDSLQPTAVSPPYGGDIS(ph)PVSPSR ddPTM_A459_Selumetinib_30min_R1 1 SSPGLYTSPGQDSLQPTAVSPPYGGDISPVSPSR 34 0 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 SSPGLYTSPGQDSLQPTAVSPPY(0.007)GGDIS(0.594)PVS(0.33)PS(0.068)R 76.678 5.0817e-06 5329500.0 872.61 993.11 1125.2 1223.3 1251.9 893.73 1161.3 827.64 485.51 559.15 True False 892.940115196513 876.8362195156866 972.4040202811824 1009.6736191849895 1138.665866040897 884.7398876419136 1073.7022060320066 805.6882986463969 823.8750097525973 630.9223490822241 1.415293207627587 1.3897688373080823 1.5412419954621948 1.6003136053964784 1.804763878942101 1.4022960019230688 1.701797705524104 1.277000727297737 1.3058263207050016 1.0 9.301318645873891 -8.375006306340223 1.2864463887865585 1.016377832119373 1.5486502332461491 0.594197799651134 0.13958299806033 0.2969429138093813 1.032900217268253 0.13410564190072807 0.04182378884241996 4.216903800666138e-09 8.375006306340223 0.5322724011267761 SSPGQT(ph)PEEGAQALAEFAALHGPALR ddPTM_A459_Selumetinib_30min_R2 1 SSPGQTPEEGAQALAEFAALHGPALR 26 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 1 S(0.277)S(0.277)PGQT(0.446)PEEGAQALAEFAALHGPALR 118.15 1.0515e-08 5877900.0 17463.0 16993.0 16559.0 19563.0 20517.0 13657.0 16239.0 14033.0 12871.0 19314.0 True False 16492.4763699278 18296.30845889304 15493.611968076006 16898.485651942672 17939.47103569281 15538.127784097449 16994.14567696804 14073.833706711797 15445.559645787733 18756.354636201453 0.8793007324619379 0.9754725165827008 0.826046013129435 0.9009472245383479 0.9564476351427061 0.8284193856149139 0.9060473640313779 0.7503501602357225 0.8234840908785341 1.0 14.195091841767967 -6.78109383498663 24.9876751929612 0.8488312788347744 0.9065060233960743 0.07981731166405659 0.07167894519114086 505.2576163367342 642354.6203756657 0.02447524643716122 0.02161527858458197 1.6554122514209034e-07 6.78109383498663 0.05767474456129995 SSPGSVAAS(ph)PSGGGGR ddPTM_A459_Selumetinib_30min_R1 2 SSPGSVAASPSGGGGR 16 0 Q9BXB5;Q9BXB5-2 Q9BXB5 OSBPL10 Oxysterol-binding protein-related protein 10 1 SSPGSVAAS(1)PSGGGGR;SSPGSVAAS(0.999)PS(0.001)GGGGR 232.26 1.9017e-15 5661800.0 1714.38 1892.07 2023.88 1978.7199999999998 2229.8 1231.0 1856.36 1817.6 898.45 1110.7 True False 1754.3217183972188 1670.5455648005202 1749.0482123770703 1633.173697174628 2028.1149837031642 1218.617257658572 1716.3332706359902 1769.3913436031269 1524.6040298082858 1253.269164134178 1.3997964432558214 1.332950345071817 1.395588643230843 1.3031308388592704 1.6182597017012614 0.9723507866727533 1.369484959618966 1.4118206960158572 1.2165016689463988 1.0 10.291480579656035 -6.753221177710438 24.999951116887683 1.230736236968318 1.398935918180164 0.3182873898395109 0.15293640102462658 285.04131075997145 867101.04439042 0.050323458533548596 0.04951364055468801 1.7651386410504286e-07 6.753221177710438 0.16819968121184603 SSPGSVAAS(ph)PSGGGGR ddPTM_A459_Selumetinib_30min_R2 1 SSPGSVAASPSGGGGR 16 0 Q9BXB5;Q9BXB5-2 Q9BXB5 OSBPL10 Oxysterol-binding protein-related protein 10 1 SSPGS(0.001)VAAS(0.99)PS(0.009)GGGGR 122.96 0.0012054 0.0 10606.0 7408.4 9749.2 10439.0 11075.0 7290.3 9659.7 8596.4 6535.2 7561.2 True False 10016.56097918194 7976.600458239466 9121.94708612638 9017.190191720569 9683.65948824379 8294.47265024571 10108.895190332427 8621.414100789369 7842.4226087446195 7342.8885096430795 1.3641172633940513 1.0863028149976894 1.242283206962348 1.2280167647757017 1.3187806781386755 1.1295926173130586 1.3766919076950273 1.174117527382754 1.0680296450702642 1.0 12.84213197971779 -8.262955808066206 2.7373308270697936 1.0113440159010487 1.2414392862018895 0.4822051135837002 0.08836248602035443 0.22509856250884902 3.1174780688463644 0.07624791701433518 0.021900616450010325 5.458133978834439e-09 8.262955808066206 0.23009527030084076 SSPNPFVGS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 1 SSPNPFVGSPPK 12 0 P98082-3;P98082 P98082-3 DAB2 Disabled homolog 2 1 S(0.361)S(0.151)PNPFVGS(0.488)PPK 115.26 0.0053003 74833000.0 3404.0 4655.5 3201.0 3585.9 3090.8 3119.2 3422.5 3179.2 2220.7 3482.9 True False 3483.306576969012 4110.431895716768 2766.3217818343974 2959.689880679681 2811.237685725062 3087.823680007001 3164.3380695294422 3094.8772885030053 3768.365706489245 3929.9641413189256 0.8863456387161812 1.0459209671916436 0.7039050948963618 0.7531086224329739 0.7153341823576002 0.7857129401111288 0.8051824280685336 0.7875077678098968 0.9588804301976539 1.0 11.940300433436713 -8.350225226947169 4.1936642695772886 0.9957202204887301 0.8085534162285565 0.34820147353504993 0.09297977110026526 0.2750763056465771 8.209548715168976 0.09605545657445484 0.0255125197149887 4.464520002165152e-09 8.350225226947169 -0.18716680426017362 SSPNPFVGS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 3 SSPNPFVGSPPK 12 0 P98082-3;P98082 P98082-3 DAB2 Disabled homolog 2 1 SSPNPFVGS(1)PPK;SSPNPFVGS(1)PPK;SSPNPFVGS(1)PPK 152.07 0.0005057 116094000.0 609096.0 506261.0 536047.0 492496.0 392377.0 402954.0 581302.0 556879.0 364857.0 452295.0 True False 575244.8827244769 545089.5908143156 501558.3196238435 425417.1951970125 343083.09336511383 458457.25584778516 608333.6948280609 558499.4256937181 437838.5949563498 439236.06814646017 1.309648556758926 1.2409946048250284 1.1418878275192155 0.9685388474408257 0.7810904391638329 1.0437604948574393 1.3849811956362754 1.2715245085644706 0.9968184006472702 1.0 18.744637001456418 -5.276376606337988 2.8247207597967874 1.0754802689567802 1.290806982515177 0.21981766583329554 0.15728257728158168 0.5001313374227891 7.854907965648752 0.048850098295879 0.14581055999505316 5.292043357190701e-06 5.276376606337988 0.21532671355839672 SSPNPFVGS(ph)PPKGLSIQNGVK ddPTM_A459_Selumetinib_30min_R1 1 SSPNPFVGSPPKGLSIQNGVK 21 1 P98082-3;P98082 P98082-3 DAB2 Disabled homolog 2 1 SSPNPFVGS(0.999)PPKGLSIQNGVK 93.229 0.00029237 30400000.0 3439.6 2274.9 6696.1 5303.3 4262.5 3640.4 3006.5 3633.5 2497.4 2471.0 True False 3519.735987703468 2008.5536504276827 5786.806399044457 4377.178210270376 3876.957627605496 3603.7808812187372 2779.7172844529646 3537.12777672863 4237.905397120836 2788.1769195782435 1.262378998616732 0.7203824249185409 2.0754803464623057 1.569906909254702 1.390499146729881 1.2925223130259134 0.9969658901248782 1.268616690673875 1.5199556984217082 1.0 11.445106392819653 -6.873213378069215 3.9800870432561712 1.2106530646988252 1.4124702705994088 0.07484605937890942 0.3400782823728293 0.7255657409893885 21.21874874753612 0.13094944304350223 0.11534233246365481 1.3390186375901832e-07 6.873213378069215 0.2018172059005836 SSPNPFVGS(ph)PPKGLSIQNGVK ddPTM_A459_Selumetinib_30min_R2 1 SSPNPFVGSPPKGLSIQNGVK 21 1 P98082-3;P98082 P98082-3 DAB2 Disabled homolog 2 1 SSPNPFVGS(0.964)PPKGLS(0.035)IQNGVK 53.033 0.023246 6864300.0 45806.0 59695.0 48835.0 56226.0 46299.0 31063.0 26449.0 22961.0 13625.0 47335.0 True False 43260.28589594647 64273.414550321926 45693.00926752771 48567.92180473998 40482.505701688424 35341.64628816131 27678.930907699247 23027.812708601814 16350.380714307985 45968.315558900045 0.941089212645094 1.3982112193771212 0.9940109554151582 1.0565521319246298 0.8806610642458161 0.7688262199400675 0.6021306321793263 0.500949674327219 0.35568805416326255 1.0 15.488352181241574 -6.619010538844062 1.1517000757366078 0.5677536850839275 1.1422316722388166 0.559269889762769 0.1912472227411522 0.31126263352580075 0.8757453257177507 0.08919459915941974 0.09246482367855562 2.404304455040031e-07 6.619010538844062 0.5744779871548891 SSPNVANQPPS(ph)PGGK ddPTM_A459_Selumetinib_30min_R1 2 SSPNVANQPPSPGGK 15 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 SSPNVANQPPS(1)PGGK;SSPNVANQPPS(1)PGGK 250.38 4.7656e-28 50810000.0 14022.5 16794.0 19950.4 19816.1 16486.5 15305.5 15384.4 15236.2 9355.0 12841.1 True False 14349.196966964731 14827.750672681219 17241.245259702897 16355.590129266457 14995.298985927977 15151.5405662821 14223.9423219485 14832.086481847477 15874.751737833503 14489.380267906188 0.9903251002907307 1.0233529936076367 1.1899228911737556 1.1287984597584138 1.0349165187652913 1.0456996977187898 0.9816805176584653 1.0236522340917769 1.0956128864252321 1.0 13.82270826957619 -6.403514409638634 7.9668571397738805 1.02919935950407 1.086385865626605 0.1660715981509716 0.05791969956757966 0.5517062913012865 34.003102987444905 0.019496692085482846 0.022096164567257735 3.9489859662556137e-07 6.403514409638634 0.05718650612253495 SSPNVANQPPS(ph)PGGK ddPTM_A459_Selumetinib_30min_R2 4 SSPNVANQPPSPGGK 15 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 SSPNVANQPPS(1)PGGK;SSPNVANQPPS(1)PGGK;SSPNVANQPPS(1)PGGK;SSPNVANQPPS(1)PGGK 229.93 7.4342e-14 72227000.0 208648.0 189864.0 202602.0 214612.0 201738.0 124839.0 165871.0 170451.0 143211.0 186144.0 True False 197052.17944412163 204425.95829101777 189566.80789637842 185381.4753736498 176393.86887939714 142034.43907438984 173584.33016715114 170946.98419031774 171857.20164967046 180769.5390598057 1.0900740272338083 1.1308650746926205 1.0486656595039623 1.0255127956724959 0.9757942062409036 0.7857210889241646 0.9602521037005166 0.9456625550932103 0.9506977920257533 1.0 17.463792068397083 -5.994510562413213 1.695231697824496 0.9260851476207719 1.102653394838767 0.6129932640006119 0.055978558892623015 0.24010134309748993 1.3917665298253883 0.019211564372263977 0.03223202545219519 1.0127201182956492e-06 5.994510562413213 0.17656824721799502 SSPPAPPLPPGS(ph)GSPGTPQALPR ddPTM_A459_Selumetinib_30min_R2 1 SSPPAPPLPPGSGSPGTPQALPR 23 0 A0A2R8Y5V0;Q9Y3L3 A0A2R8Y5V0 SH3BP1 SH3 domain-binding protein 1 1 S(0.232)S(0.232)PPAPPLPPGS(0.304)GS(0.095)PGT(0.137)PQALPR 108.36 1.8073e-05 4370100.0 10757.0 8167.3 9339.8 10862.0 9034.0 8829.9 9337.4 8489.9 6492.6 7449.2 True False 10159.169003682833 8793.705647991364 8738.887436405357 9382.576862004871 7899.068155015292 10046.138575148429 9771.607601707086 8514.604203421399 7791.301418401176 7234.122240654026 1.4043402455367353 1.2155870961887891 1.2080093680605661 1.2969889849631027 1.0919179815105182 1.3887156231189386 1.3507661712976045 1.17700585090633 1.0770209790782823 1.0 12.82060226121471 -8.217491912563009 2.386849707574606 1.0140977332671577 1.2713704343660286 0.5332608394542382 0.08978658877860289 0.24005979440000846 2.4618387779666153 0.08223261243286471 0.024238640201809075 6.060494862827031e-09 8.217491912563009 0.2572727010988709 SSPQLDPLRKS(ph)PT(ph)MEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R1 1 SSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGR 33 2 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 2 S(0.17)S(0.514)PQLDPLRKS(0.671)PT(0.635)MEQAVQT(0.009)AS(0.001)AHLPAPAAVGR 57.078 0.0010038 18038000.0 618.15 666.33 1088.9 1151.8 1115.9 858.52 735.99 806.45 216.73 430.91 True False 632.551692289481 588.3157738315872 941.0333608995547 950.6597519637628 1014.9670420281466 849.8840682737914 680.4736817510515 785.0603262812178 367.7749806670931 486.22149591884306 1.3009537784710827 1.2099748340410377 1.93540057113523 1.9551989369931946 2.087458186335633 1.7479360238232835 1.3995137760520397 1.6146146002813808 0.756393914613104 1.0 8.925469866296407 -8.233766923160319 7.669046026154341 0.8777697736484633 1.6706293423141187 0.5517446265128187 0.28034147103119894 0.16532592462836643 40.367029640408084 0.22337388595063418 0.08026309154447527 5.837583111968685e-09 8.233766923160319 0.7928595686656554 SSPQLDPLRKS(ph)PT(ph)MEQAVQTASAHLPAPAAVGR ddPTM_A459_Selumetinib_30min_R2 2 SSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGR 33 2 Q8ND56-3;Q8ND56-2;Q8ND56 Q8ND56-3 LSM14A Protein LSM14 homolog A 2 S(0.355)S(0.355)PQLDPLRKS(0.817)PT(0.473)MEQAVQTASAHLPAPAAVGR;S(0.328)S(0.328)PQLDPLRKS(0.67)PT(0.67)MEQAVQT(0.003)AS(0.001)AHLPAPAAVGR 71.86399999999998 5.813e-05 43702000.0 46356.0 51662.0 57938.0 71000.0 75374.0 38767.0 24570.8 28959.0 24105.0 73546.0 True False 43779.719097770896 55624.309280488 54210.33215812477 61329.677518168486 65904.84426789045 44106.80235821234 25713.390886116544 29043.265895579472 28926.673549973853 71422.53588454338 0.6129678616920309 0.7788061371890564 0.7590087846468706 0.858688042347162 0.9227457895702215 0.6175474142994906 0.36001789305945386 0.40664008265582674 0.40500765188083865 1.0 16.124091737823832 -6.980618602165441 7.192452052430778 0.4924668628945189 0.7875036683649754 0.2657967351621733 0.18571688004762976 0.17367903697138162 39.86680453890808 0.06374615372752876 0.05512394706090734 1.0456380965103515e-07 6.980618602165441 0.2950368054704565 SSPS(ph)ARPPDVPGQQPQAAK ddPTM_A459_Selumetinib_30min_R2 1 SSPSARPPDVPGQQPQAAK 19 1 A0A0A6YYC7;Q96JP5-2;Q96JP5 A0A0A6YYC7 ZFP91-CNTF;ZFP91 E3 ubiquitin-protein ligase ZFP91 1 S(0.324)S(0.324)PS(0.353)ARPPDVPGQQPQAAK 79.514 0.0037783 60492000.0 22950.0 20321.0 20341.0 24151.0 28255.0 24151.0 25613.0 26591.0 18186.0 23195.0 True False 21674.530876129134 21879.555357686444 19032.282205606258 20861.592137201216 24705.3542970951 27477.581029050125 26804.05525119666 26668.375407622985 21823.708159295787 22525.30008215246 0.9622305051244393 0.9713324696181225 0.8449291301866458 0.9261404758700883 1.0967824715760377 1.2198541608252103 1.1899533037712737 1.1839298615494682 0.9688531597671116 1.0 14.45925870530633 -6.300846996756614 4.472291367116729 1.1309998202148717 0.9225533509553107 0.5383899773061702 0.08239920956970145 0.15221117252415567 7.1163302360761085 0.02619280910707033 0.03079589640778521 5.002107296725906e-07 6.300846996756614 -0.208446469259561 SSPS(ph)PALEQPFR ddPTM_A459_Selumetinib_30min_R1 2 SSPSPALEQPFR 12 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.052)S(0.011)PS(0.936)PALEQPFR;SS(0.003)PS(0.997)PALEQPFR 175.01 0.0001195 45962000.0 3647.5 3967.5 4238.5 3989.8999999999996 4105.5 3906.5 4205.9 3901.5 2290.5 3654.1 True False 3732.479653200489 3502.9832555592893 3662.9349804139624 3293.1388646989176 3734.1582498848966 3867.204156818204 3888.6455768104843 3798.0195461419476 3886.8112084989475 4123.13932894814 0.9052518858616129 0.8495912886002182 0.8883849630539695 0.7986969641258849 0.9056590020297769 0.9379271104585184 0.9431273761496975 0.9211475148260065 0.9426824801214072 1.0 12.009527498201004 -6.541322562914915 4.504450478738815 0.9426256433934651 0.860435340131946 0.6178354802472321 0.032542094607769814 0.13657957666978426 6.865728812541096 0.01039151987479703 0.010792683728161327 2.8752620822119677e-07 6.541322562914915 -0.0821903032615191 SSPS(ph)PALEQPFR ddPTM_A459_Selumetinib_30min_R2 2 SSPSPALEQPFR 12 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 S(0.402)S(0.047)PS(0.551)PALEQPFR;S(0.018)S(0.026)PS(0.955)PALEQPFR 132.51 0.0018735 24669900.0 55387.0 43772.0 60070.0 63878.0 65068.0 42140.0 48729.0 45452.0 40130.0 44806.0 True False 52308.812271728304 47129.1716508366 56205.16159927085 55177.70620430371 56893.57612469946 47944.40249116692 50994.99505468166 45584.25779501632 48157.12132588473 43512.334360031164 1.2021605607024675 1.0831221156943427 1.2917064190171064 1.2680934501870331 1.3075275542320666 1.1018577420936277 1.1719664275590738 1.0476169220856224 1.106746444063918 1.0 15.409136796549738 -7.514251386761072 1.204009956977418 1.0438792293756742 1.221993211018705 0.5054741777511289 0.07138191200323357 0.4405226067598194 1.1971407146916588 0.05683523001449 0.02639920442989118 3.0601915614517157e-08 7.514251386761072 0.17811398164303083 SSPS(ph)PEVVKPK ddPTM_A459_Selumetinib_30min_R1 2 SSPSPEVVKPK 11 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 S(0.002)S(0.002)PS(0.997)PEVVKPK;S(0.004)S(0.004)PS(0.992)PEVVKPK 163.71 0.003047 43643000.0 7375.9 7780.799999999999 7785.1 8647.2 7693.4 7341.4 7735.3 7233.299999999999 4125.0 5958.799999999999 True False 7547.744118996979 6869.8203188042135 6727.926180493274 7137.12884804744 6997.533328380087 7267.552181457868 7151.820093274238 7041.449386930292 6999.823721920178 6723.670023627213 1.12256313776166 1.0217366846771814 1.000633010967389 1.0614930273150407 1.0407312232442267 1.0808906677334602 1.063678031215466 1.0472627838942707 1.0410718695775598 1.0 12.715033208082378 -8.77700939805794 1.8388518805619647 1.0000621971389418 1.0529435758121843 0.21828532868743056 0.03114415906784609 1.6649802849003414 9.190276641866385 0.030185928594034295 0.008459856628114722 1.6710544525883163e-09 8.77700939805794 0.052881378673242496 SSPS(ph)PEVVKPK ddPTM_A459_Selumetinib_30min_R2 1 SSPSPEVVKPK 11 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 S(0.009)S(0.034)PS(0.957)PEVVKPK 90.861 0.014976 32091000.0 243840.0 217600.0 290350.0 259810.0 227580.0 199370.0 233860.0 232920.0 167660.0 211680.0 True False 230288.34896885947 234289.220305721 271669.1971091775 224423.42980275082 198989.36580898587 226831.4077993345 244734.95338479898 233597.75863801842 201196.684811807 205568.24838930977 1.1202525233018195 1.1397150199091974 1.3215523274522643 1.0917222458291937 0.9679966014602378 1.1034360100678393 1.1905289620472634 1.1363513600389576 0.9787342470845799 1.0 17.649257920735174 -7.785845806029322 0.17776961743192196 0.9483646892357411 1.2262448012450737 0.23187426465153582 0.08875211274322028 6.049627689339354 1.0816762670736375 0.6430500186846385 0.7245800394873423 1.6373977676994356e-08 7.785845806029322 0.2778801120093326 SSPS(ph)TENMHFPSSISSQTR ddPTM_A459_Selumetinib_30min_R1 1 SSPSTENMHFPSSISSQTR 19 0 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 S(0.268)S(0.057)PS(0.643)T(0.032)ENMHFPSSISSQTR 115.53 0.0014269 0.0 452.73 652.41 468.46 564.48 671.28 577.36 761.17 471.49 272.97 442.87 True False 463.2777281407698 576.0255339028195 404.845705066586 465.9041646019314 610.5628425241097 571.5522826009367 703.754334078517 458.984553584638 463.21015306001186 499.7166784191083 0.9270807802660982 1.1527042397806695 0.8101504763606173 0.9323366313805148 1.2218180198741249 1.1437526648281697 1.4083066755044025 0.9184895629993189 0.9269455534792483 1.0 8.964966559681608 -4.7310202341287715 23.38292812751439 1.0618239039568673 0.9270789439402134 0.05039886211993916 0.16831089201889504 6123.403012307636 4706419.790519794 0.04453390265661679 4.735128987595654 1.85771790050614e-05 4.7310202341287715 -0.13474496001665393 SSPS(ph)TENMHFPSSISSQTR ddPTM_A459_Selumetinib_30min_R2 2 SSPSTENMHFPSSISSQTR 19 0 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 S(0.056)S(0.056)PS(0.725)T(0.162)ENMHFPSSISSQTR;S(0.006)S(0.006)PS(0.655)T(0.331)ENMHFPS(0.001)S(0.001)ISSQTR 92.428 0.0014905 17756800.0 38027.0 26940.0 44509.0 57294.0 60873.0 51099.0 38305.0 42613.0 35341.0 55917.0 True False 35913.61157414216 29006.211374246966 41645.33939773507 49490.45836233724 53225.589528475284 58137.42341946221 40086.258399917526 42736.996775038075 42410.18751004463 54302.53092018622 0.6613616523128164 0.5341594743876718 0.7669134143847794 0.9113840096160203 0.9801677495788581 1.070620879621845 0.738202395369679 0.7870166648006306 0.7809983584812844 1.0 15.728731819953113 -5.493881662139736 3.599725957152873 0.8898303363790524 0.6003154737592366 0.5653855328316875 0.10384218755815894 0.17999289908400407 4.872633269308093 0.030969394395406098 0.06553541953560689 3.207143097406031e-06 5.493881662139736 -0.28951486261981585 SSPST(ph)GSLDSGNESK ddPTM_A459_Selumetinib_30min_R1 3 SSPSTGSLDSGNESK 15 0 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 SS(0.011)PS(0.044)T(0.85)GS(0.073)LDS(0.022)GNESK;SSPS(0.005)T(0.541)GS(0.385)LDS(0.069)GNESK;SSPS(0.001)T(0.975)GS(0.024)LDSGNESK 269.87 1.5706e-44 44013000.0 8766.26 9407.43 10271.3 11226.67 9231.06 7976.63 9479.400000000001 8941.94 5070.88 7518.12 True False 8970.49680182737 8306.003722204448 8876.51387621232 9266.14283519623 8396.112252876013 7896.392344400563 8764.361226091276 8704.770703685383 8604.912997578323 8483.143934690235 1.0574495577216598 0.97911856572875 1.0463707729764518 1.092300555847469 0.9897406336042087 0.9308332388549649 1.033150126128481 1.0261255462245367 1.0143542375121253 1.0 13.05038332520391 SSPST(ph)GSLDSGNESK ddPTM_A459_Selumetinib_30min_R2 1 SSPSTGSLDSGNESK 15 0 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 SSPS(0.075)T(0.538)GS(0.321)LDS(0.065)GNES(0.001)K 148.18 0.00072416 15923000.0 49490.0 39014.0 41607.0 45684.0 48040.0 40090.0 42053.0 38201.0 28207.0 42039.0 True False 46739.54392416691 42006.248350217946 38930.050918276385 39461.760390704316 42004.78571695093 45612.03359921407 44008.54782643864 38312.15858548398 33849.18816943012 40825.224839560586 1.1448692348382417 1.0289287692915023 0.9535783592440198 0.9666024019655848 1.028892942586989 1.1172512528336391 1.07797441408806 0.9384432966639442 0.8291243539369187 1.0 15.317173210811639 -7.887591737417926 5.391108480071926 0.9053068324344786 1.0399855485719474 0.40468111608097956 0.06814788597480088 0.21026969647309554 8.991276282140575 0.04055594024349147 0.01897397237195347 1.2954130343598612e-08 7.887591737417926 0.13467871613746873 SSPSTGSLDS(ph)GNESK ddPTM_A459_Selumetinib_30min_R2 1 SSPSTGSLDSGNESK 15 0 A0A0U1RQT1;A0A087X1H5;Q15057 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 SSPST(0.128)GS(0.14)LDS(0.724)GNES(0.007)K 153.22 0.00021178 17715000.0 57981.0 43529.0 46816.0 53925.0 50588.0 36563.0 44293.0 45506.0 34123.0 43193.0 True False 54758.64813633307 46867.53433220474 43803.90952940676 46580.32197418638 44232.68317754191 41599.22136413232 46352.71226491445 45638.41492607615 40948.553476281195 41945.90586110852 1.305458709549632 1.1173327496464789 1.0442952328756583 1.1104855412688752 1.054517294822655 0.9917349622124232 1.105059273684487 1.088030261575332 0.976222890783912 1.0 15.356242382535806 SSPSVLIHS(ph)LGK ddPTM_A459_Selumetinib_30min_R1 1 SSPSVLIHSLGK 12 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 SSPSVLIHS(1)LGK 75.998 0.032142000000000004 15829000.0 5216.0 7166.5 6167.9 7096.2 6063.9 5945.6 6990.4 6610.2 3376.4 4882.1 True False 5337.522651430774 6327.442848384534 5330.333057849537 5856.981882171604 5515.4213156684955 5885.792662172876 6463.108499996669 6434.876023044336 5729.504197500917 5508.765090681076 0.9689145504606859 1.1486136628131733 0.9676094315342318 1.0632114068685903 1.001208297118837 1.0684413957185432 1.17324089766144 1.1681158875207656 1.0400705245524546 1.0 12.427513228281146 -7.004296631806578 24.030368858166927 1.1110057252650984 1.03488780044496 0.14973505070943882 0.0694534499483281 172.01292351251644 962049.8300794872 0.02371911820003444 0.020397236859237083 9.901554179486218e-08 7.004296631806578 -0.07611792482013846 SSPSVLIHS(ph)LGK ddPTM_A459_Selumetinib_30min_R2 2 SSPSVLIHSLGK 12 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 SSPSVLIHS(1)LGK;SSPSVLIHS(1)LGK 72.428 0.03788 23871800.0 154011.0 122701.0 167486.0 173865.0 179955.0 153298.0 140210.0 159789.0 132527.0 199777.0 True False 145451.6851748812 132111.7721541007 156710.13310496882 150184.28706614603 157347.44408188816 174413.40799930962 146730.0428208443 160253.95953550687 159036.10311376842 194008.9189270172 0.749716487155921 0.6809572100332092 0.8077470560202465 0.7741102207916677 0.8110320131265695 0.8989968552163364 0.7563056566282997 0.8260133627969529 0.8197360409682766 1.0 17.565763451570902 -14.522878745151596 0.08775705052486177 1.650036666076835 0.6197161299715048 0.6771388262000115 0.04712177809033316 136.47560943326388 0.832729424341031 16.84936936461173 1.251697676630781 3.0000000008893155e-15 14.522878745151596 -1.0303205361053303 SSPVCSTAPVET(ph)EPKLSPSWNPK ddPTM_A459_Selumetinib_30min_R1 1 SSPVCSTAPVETEPKLSPSWNPK 23 1 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 SSPVCST(0.001)APVET(0.69)EPKLS(0.231)PS(0.077)WNPK 92.932 0.00015971 17452000.0 972.88 1064.2 1632.2 1426.0 1039.4 1100.7 1179.7 1103.8 660.0 802.64 True False 995.5462111050566 939.6029692668424 1410.556205032835 1176.975869335237 945.3864535209752 1089.6279573556385 1090.7142792180816 1074.5236383522956 1119.971795507228 905.6666623756704 1.0992413130164487 1.0374710788207142 1.557478334614614 1.2995685037670377 1.0438569650351435 1.203122520263047 1.2043219923288437 1.1864449504342949 1.2366269423779055 1.0 9.822836342665413 -6.225895974946193 24.95256469609504 1.160850398326244 1.255444790787592 0.09959663956589193 0.14653239946496424 1681.2776293103125 1180308.4030752664 0.0453908581687929 0.05859737290859102 5.944345244085142e-07 6.225895974946193 0.09459439246134815 SSPVCSTAPVETEPKLS(ph)PSWNPK ddPTM_A459_Selumetinib_30min_R1 1 SSPVCSTAPVETEPKLSPSWNPK 23 1 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 SSPVCSTAPVET(0.061)EPKLS(0.615)PS(0.324)WNPK 100.81 2.4807e-05 18513000.0 3364.8 3675.8 4799.3 4833.1 3198.8 3282.6 3096.1 3076.1 2426.6 2989.6 True False 3443.1932932389345 3245.4356271669426 4147.581420667863 3989.089813523233 2909.4691047940087 3249.580024362331 2862.558684315588 2994.5118354190013 4117.76296814824 3373.3442811700165 1.0207061616742812 0.9620825378787872 1.2295161937130559 1.1825326681863761 0.8624880422181169 0.9633111101352635 0.8485818362194366 0.8876982560405544 1.2206767601912332 1.0 11.71996385098425 -6.260089455242899 24.999844929050045 0.9523929616011062 1.0982936712462243 0.22677227721613746 0.12095278011326183 185.14727398260058 3428821.3283672608 0.03777506337468597 0.046111466730356473 5.49427692014719e-07 6.260089455242899 0.14590070964511814 SSPVNNHHS(ph)PGQTPTLGQPEAR ddPTM_A459_Selumetinib_30min_R2 2 SSPVNNHHSPGQTPTLGQPEAR 22 0 H0Y2V6;Q5SW79-3;Q5SW79;Q5SW79-2;E7EWM2;E7EMW0;Q96L14 H0Y2V6 CEP170;CEP170P1 Centrosomal protein of 170 kDa;Cep170-like protein 1 S(0.005)S(0.005)PVNNHHS(0.985)PGQT(0.002)PT(0.002)LGQPEAR;S(0.007)S(0.007)PVNNHHS(0.985)PGQTPT(0.001)LGQPEAR 80.355 0.00078453 23820000.0 38034.0 47191.0 48758.0 55175.0 57984.0 41394.0 34718.0 41700.0 31016.0 54169.0 True False 35920.222542165386 50810.39795701886 45620.96336369646 47660.069817816126 50699.531536462986 47095.64776268068 36332.45579241187 41821.340096193366 37220.06665944782 52605.000222035684 0.6828290540928234 0.965885329199845 0.867236254560195 0.905998852136718 0.9637778029174018 0.8952694147685377 0.6906654431909419 0.795006936976969 0.7075385705227452 1.0 15.682912316950672 -7.224294275373681 24.497641540196582 0.7812199587882722 0.8884494978883958 0.11077200914659402 0.10790680298513576 734.410952616126 484353.29820228496 0.03896864451345898 0.030184185795272173 5.966308760314918e-08 7.224294275373681 0.10722953910012356 SSQASQNRHS(ph)MEISPPVLISSSNPTAAAR ddPTM_A459_Selumetinib_30min_R1 1 SSQASQNRHSMEISPPVLISSSNPTAAAR 29 1 Q7Z6J0;Q7Z6J0-3;H0YA90 Q7Z6J0 SH3RF1 E3 ubiquitin-protein ligase SH3RF1 1 S(0.015)S(0.015)QAS(0.075)QNRHS(0.84)MEIS(0.054)PPVLISSSNPTAAAR 63.042 0.00079638 9500400.0 510.9 537.44 753.37 570.91 845.05 596.02 714.78 604.45 137.88 383.82 True False 522.8029759616529 474.51627495092265 651.066491965192 471.2112858079801 768.6153767056951 590.024579942861 660.8635691273204 588.418022469691 233.97228964323727 433.0870357233999 1.2071545274690514 1.09566030799865 1.503315588465246 1.0880290725417352 1.7747365155409256 1.362369526848854 1.5259370856563685 1.358659978096173 0.5402431159187794 1.0 8.758513176362849 -8.245939949534462 23.876341090518345 0.7701216371443254 1.3699212546325479 0.5339919633221439 0.22204903744724167 285.5669109086133 439908.95228288876 0.14830528011057498 0.05553796446437003 5.676230859684704e-09 8.245939949534462 0.5997996174882225 SSQDGDT(ph)PAQASPPEEK ddPTM_A459_Selumetinib_30min_R1 1 SSQDGDTPAQASPPEEK 17 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4;E9PNX6 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 SSQDGDT(0.631)PAQAS(0.369)PPEEK 224.15 4.8211e-12 10256000.0 4700.5 5220.9 5842.5 5702.1 4435.0 4816.4 4784.2 4445.1 3372.6 4228.3 True False 4810.012504419165 4609.634600869441 5049.1205905552815 4706.335276673531 4033.8550330628436 4767.951388941305 4423.323942218483 4327.201508280295 5723.055875041933 4771.043492129778 1.008167817449929 0.9661690589225199 1.0582843352579396 0.9864373033775548 0.8454869547337 0.9993519021166807 0.92711876333031 0.906971717071614 1.199539657201318 1.0 12.220089122439756 -8.24983072993323 24.981123256811603 1.0997698400268074 0.962560395502666 0.37173229001414465 0.07151244996662326 671.135767073723 1444251.894007623 0.048532202838790915 0.01799796985047055 5.625605453511623e-09 8.24983072993323 -0.1372094445241414 SSQDGDTPAQAS(ph)PPEEK ddPTM_A459_Selumetinib_30min_R1 1 SSQDGDTPAQASPPEEK 17 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4;E9PNX6 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 SSQDGDT(0.025)PAQAS(0.975)PPEEK 257.37 4.777499999999999e-40 9488700.0 2909.0 3391.6 3446.9 3317.9 2679.4 2857.3 2583.9 2613.0 1659.0 2027.4 True False 2976.7740400713446 2994.5098952879375 2978.8299124664113 2738.4910496966213 2437.0487430864914 2828.5581562208254 2388.9943426901755 2543.6947517798035 2815.2018314340785 2287.636538548334 1.301244314781017 1.3089972313469709 1.3021430031698513 1.197083104571492 1.0653129122657614 1.2364543530222436 1.044306777949158 1.1119313356456337 1.230615871007429 1.0 11.159642138488465 -5.912380310374536 3.214229592887719 1.1228395101655877 1.3057769707903262 0.5895165902980708 0.07044646680379386 0.17197738463522713 3.5566064272676914 0.019917761393331995 0.03109363807423717 1.2235442759428008e-06 5.912380310374536 0.18293746062473848 SSQDGDTPAQAS(ph)PPEEK ddPTM_A459_Selumetinib_30min_R2 2 SSQDGDTPAQASPPEEK 17 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4;E9PNX6 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 SSQDGDT(0.104)PAQAS(0.896)PPEEK;SSQDGDT(0.018)PAQAS(0.982)PPEEK 179.07 8.3058e-08 18903500.0 133050.0 117736.0 123956.0 121687.0 115073.0 98883.0 112601.0 114895.0 86351.0 114632.0 True False 125655.61364134998 126765.97261909192 115980.80591308825 105113.02067821617 100616.50097432762 112503.23567949834 117837.16961464855 115229.32542810895 103623.61284852886 111322.27631029522 1.128755338159836 1.1387296129819477 1.04184723630523 0.9442227033269458 0.9038307902892072 1.0106084730598874 1.0585228178966983 1.0350967411672698 0.930843459935122 1.0 16.764382788650146 -5.421591168720876 3.438077209639743 0.9858721780177727 1.1336190041142795 0.6348632708823265 0.045131206005991964 0.16918899791673195 3.6860253102410816 0.01365036159691939 0.031167717438082974 3.787990064981435e-06 5.421591168720876 0.1477468260965068 SSQGTESGKDS(ph)EQENGLGSLSPSDLNK ddPTM_A459_Selumetinib_30min_R2 1 SSQGTESGKDSEQENGLGSLSPSDLNK 27 1 Q86US8 Q86US8 SMG6 Telomerase-binding protein EST1A 1 S(0.019)S(0.019)QGT(0.067)ES(0.059)GKDS(0.792)EQENGLGS(0.029)LS(0.011)PS(0.004)DLNK 43.15 0.038598 6000200.0 12260.0 8756.2 9663.7 9380.8 10707.0 7775.0 9964.1 12732.0 9403.7 8424.1 True False 11578.638280668545 9427.772384379403 9041.948063041018 8103.11885721739 9361.890938205532 8845.935675577186 10427.450393489587 12769.04801210394 11284.702761331222 8180.874344559629 1.415330170468694 1.1524162317257658 1.105254485304986 0.9904954551228442 1.144363125981918 1.0812946517703002 1.2746131958895024 1.560841479076805 1.3794005733428325 1.0 12.998039326502708 -7.516299099222451 24.688762391725504 1.365618083667226 1.1423291295624223 0.15602411390015303 0.16576108432587502 346.1234639186468 1298774.0729906037 0.07378116809919845 0.044627114804059134 3.0457966227052955e-08 7.516299099222451 -0.22328895410480376 SSQKS(ph)PELGK ddPTM_A459_Selumetinib_30min_R2 1 SSQKSPELGK 10 1 Q9UEG4 Q9UEG4 ZNF629 Zinc finger protein 629 1 SSQKS(1)PELGK 84.89200000000002 0.020476 15241000.0 165630.0 155750.0 135360.0 157450.0 135210.0 100370.0 182480.0 202990.0 110750.0 183100.0 True False 156424.9476694235 167695.5241848164 126651.08496882499 136005.0383836 118223.71100726345 114195.0564318563 190965.68157726002 203580.66729319657 132903.09461354953 177813.42724906735 0.8797139231241266 0.9430982056823045 0.7122695227701894 0.7648749618502917 0.6648750481686897 0.642218409478721 1.0739665982016646 1.1449116663615986 0.7474300263465994 1.0 17.440004745141195 -7.26987642445653 24.96207856085413 1.0036530504107521 0.7684667239553284 0.42270500649221665 0.12777894717678215 628.1354208028837 1858411.1510277994 0.055255033522503175 0.03793854686750662 5.371846268607846e-08 7.26987642445653 -0.2351863264554237 SSQLDSGVPS(ph)SPGGR ddPTM_A459_Selumetinib_30min_R1 1 SSQLDSGVPSSPGGR 15 0 Q70CQ4;I3L4X5 Q70CQ4 USP31 Ubiquitin carboxyl-terminal hydrolase 31 1 SSQLDS(0.01)GVPS(0.771)S(0.22)PGGR 117.48 0.0021356 4153500.0 3857.4 5046.8 5197.2 5394.0 4911.6 4682.9 4527.7 4244.6 2465.6 3963.6 True False 3947.26991480619 4455.918309806335 4491.448786176111 4452.039157920242 4467.346647213409 4635.794277733005 4186.171943727817 4132.0194195960785 4183.94311970094 4472.366668733441 0.8825908533845781 0.9963222248653946 1.0042666710616717 0.995454864880532 0.9988775469696778 1.0365416391598874 0.9360082152909271 0.9238999674340772 0.9355098607972182 1.0 12.126822757610189 -9.855843298365293 7.321927016703161 0.9999992286897592 0.9711701959161413 0.039977241848944134 0.044662812356043864 0.0 0.0 0.045601372853226727 0.011059957467472212 1.393659570876815e-10 9.855843298365293 -0.028829032773617924 SSQLDSGVPSS(ph)PGGR ddPTM_A459_Selumetinib_30min_R2 2 SSQLDSGVPSSPGGR 15 0 Q70CQ4;I3L4X5 Q70CQ4 USP31 Ubiquitin carboxyl-terminal hydrolase 31 1 SSQLDSGVPS(0.101)S(0.899)PGGR;SSQLDS(0.001)GVPS(0.033)S(0.966)PGGR 196.45 1.9646e-05 9468600.0 105385.0 97210.0 109776.0 105081.0 113361.0 91640.0 80415.0 80825.0 73874.0 94892.0 True False 99528.12358958024 104665.69442058468 102713.13167507185 90768.78652516412 99119.57771980163 104262.578174906 84154.45683929962 81060.18736870088 88650.86421202107 92152.22140097505 1.0800404165680497 1.1357913333978211 1.1146028832896377 0.984987503776048 1.0756070359770282 1.1314168729719065 0.9132113752648962 0.8796335686362867 0.9620046360714541 1.0 16.491731323110734 -7.2683109801595736 24.97809111936681 0.9286818497191981 1.085378495942407 0.6809111927189662 0.04955717917840809 317.2347616858348 1153134.3638307764 0.02118234776315648 0.014631708501341148 5.391244397481008e-08 7.2683109801595736 0.156696646223209 SSQPDPDKNPAS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 SSQPDPDKNPASSK 14 1 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 SSQPDPDKNPAS(0.915)S(0.085)K 154.47 0.0003927 0.0 752.23 1046.2 1096.1 1137.2 675.69 737.37 771.41 829.22 454.46 547.25 True False 769.7554954152175 923.7104176348154 947.2556404463239 938.6093678878196 614.5739588027586 729.9527272783928 713.2219226342456 807.2263919138343 771.1854275548709 617.4948681664079 1.246577963799008 1.495899747924522 1.5340299802962076 1.5200278031053613 0.995269743095481 1.1821195039983374 1.1550248583475522 1.3072600818705038 1.2488936626223834 1.0 9.270283336671815 -6.247892527937521 24.986828302494757 1.1655053966329942 1.458538315435816 0.6066634890720927 0.11815630762963986 570.2397349681789 1051792.4843431378 0.0357445008671117 0.04588618286795881 5.650767934316312e-07 6.247892527937521 0.2930329188028218 SSQPS(ph)PTAVPASDS(ph)PPTK ddPTM_A459_Selumetinib_30min_R1 2 SSQPSPTAVPASDSPPTK 18 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 S(0.017)S(0.025)QPS(0.932)PT(0.027)AVPAS(0.002)DS(0.997)PPT(0.002)K;S(0.15)S(0.213)QPS(0.636)PT(0.001)AVPASDS(0.999)PPT(0.001)K 226.11 2.3649e-17 16640000.0 5840.5 8067.9 5391.700000000001 5269.1 5590.1 5274.7 5985.299999999999 5687.7 2839.2 5243.6 True False 5976.572286365309 7123.306517335049 4659.536754488137 4348.950598256871 5084.476442012312 5221.64130704441 5533.824002207326 5536.843719746649 4817.9150330365455 5916.667136989267 1.0101248131742162 1.2039390339879399 0.7875272761852835 0.7350338455020576 0.859348062733774 0.8825308549808794 0.9352941232085681 0.9358044979633764 0.8142954338121126 1.0 12.530569018127087 -5.264341665969827 24.999139225319066 0.8641969146758703 1.1070319281795888 0.5546697420170184 0.08533350570986101 168.08939936210356 1447868.1980577724 0.022647117501781007 0.05066324588745651 5.4407445291255315e-06 5.264341665969827 0.2428350135037185 SSQPS(ph)PTAVPASDS(ph)PPTKQEVK ddPTM_A459_Selumetinib_30min_R1 1 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 S(0.004)S(0.007)QPS(0.966)PT(0.023)AVPAS(0.004)DS(0.665)PPT(0.33)KQEVK 128.18 5.4097e-05 39818000.0 2325.7 3145.9 3486.2 3872.8 2979.9 3015.8 2931.5 2237.7 1391.8 2291.9 True False 2379.884284975565 2777.576565510767 3012.7931883258575 3196.4881814596774 2710.368571144074 2985.463790127312 2710.374594835809 2178.3489269260117 2361.7829469499384 2586.0876899965087 0.920264341453471 1.0740457782058106 1.1650003980839199 1.2360324028548284 1.0480574891672498 1.1544325436742413 1.0480598184354175 0.8423337442702697 0.9132648347872252 1.0 11.33655548006478 -7.601896897141383 5.289279035391333 0.9101913544508522 1.105099953313299 0.4662818652652668 0.08628894707506815 0.1754896145187263 8.534530422156418 0.04317289170380999 0.024428794927811453 2.500939021915211e-08 7.601896897141383 0.19490859886244682 SSQPS(ph)PTAVPASDS(ph)PPTKQEVK ddPTM_A459_Selumetinib_30min_R2 3 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 S(0.01)S(0.013)QPS(0.638)PT(0.339)AVPASDS(0.942)PPT(0.058)KQEVK;S(0.005)S(0.008)QPS(0.966)PT(0.021)AVPAS(0.316)DS(0.391)PPT(0.293)KQEVK;S(0.003)S(0.005)QPS(0.969)PT(0.022)AVPAS(0.012)DS(0.717)PPT(0.271)KQEVK 142.78 8.7214e-06 97827000.0 175847.0 193047.0 190681.0 185428.0 179310.0 132921.0 139603.0 140326.0 91287.0 187069.0 True False 166074.12771131523 207853.0841560599 178412.79205777505 160172.38651885855 156783.4747482613 151229.6612132983 146094.81611809647 140734.32542778007 109546.95077189228 181667.83190636704 0.9141636467424298 1.1441380786841169 0.9820824643832946 0.8816772063499531 0.8630227657974621 0.8324515112353144 0.8041864901728712 0.7746793912326515 0.6030068704092512 1.0 17.4709434572574 -6.0631122072129235 1.104368991346912 0.7844352805331017 1.0402090206372492 0.4180218682463358 0.10567238117997475 0.45209352785553425 1.129203817250369 0.04158205350794575 0.07806794785779093 8.647444687743991e-07 6.0631122072129235 0.25577374010414744 SSQPS(ph)PTAVPASDSPPTK ddPTM_A459_Selumetinib_30min_R1 1 SSQPSPTAVPASDSPPTK 18 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 SSQPS(0.87)PT(0.121)AVPASDS(0.008)PPT(0.001)K 184.97 3.0524e-10 24771000.0 7129.8 12105.0 8750.1 10160.0 9754.4 8898.7 9848.5 8075.1 4738.6 7476.3 True False 7295.910467824221 10687.740972538175 7561.884480858843 8385.746726820482 8872.116242279195 8809.187157373139 9105.619715927158 7860.92211637853 8041.058106349324 8435.955930328944 0.8648587697801938 1.2669270751064043 0.8963873855329614 0.9940481903979665 1.0517025356168785 1.0442429085839997 1.0793820867639479 0.9318353700873361 0.953188728433267 1.0 13.042335843133905 -7.771742197590325 24.997279759587393 0.9568840274408893 1.032536730975251 0.07753551631075661 0.10405368009652813 512.1147183253848 1242500.9994021866 0.05296223042567799 0.025871554819983354 1.691444695534655e-08 7.771742197590325 0.0756527035343616 SSQPS(ph)PTAVPASDSPPTK ddPTM_A459_Selumetinib_30min_R2 4 SSQPSPTAVPASDSPPTK 18 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 SSQPS(0.969)PT(0.031)AVPASDSPPTK;SSQPS(0.919)PT(0.081)AVPASDSPPTK;SSQPS(0.964)PT(0.036)AVPASDSPPTK;SSQPS(0.596)PT(0.404)AVPASDSPPTK 260.98 1.1607e-42 105387500.0 275335.0 236089.0 285624.0 264604.0 255555.0 189556.0 205667.0 216682.0 193414.0 227707.0 True False 260032.98295333417 254196.26715421613 267247.2628038977 228564.4787326399 223449.89620931316 215665.61838195636 215230.92302142904 217312.50874636366 232102.20443869138 221132.5072561622 1.1759147769807956 1.149520123966905 1.2085390163569019 1.033608679106905 1.010479639479086 0.9752777692342043 0.9733120005377739 0.9827252964424021 1.0496068955154647 1.0 17.75455159642496 -5.864002426341511 4.565645117111584 0.9974512213931929 1.174801395256862 0.9109609797658887 0.025119486697009467 0.057753880187239974 2.0651919982179145 0.0074673350494672015 0.011462302144625994 1.3677211843107463e-06 5.864002426341511 0.17735017386366903 SSQPSPT(ph)AVPASDS(ph)PPTKQEVK ddPTM_A459_Selumetinib_30min_R1 1 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 S(0.001)S(0.001)QPS(0.271)PT(0.727)AVPAS(0.003)DS(0.972)PPT(0.025)KQEVK 129.42 8.666e-05 41704000.0 4846.4 6457.5 7463.0 8802.7 6030.3 6177.4 5700.7 5357.4 3167.9 4883.0 True False 4959.311690547186 5701.452897989698 6449.565591324617 7265.473692143961 5484.86042973594 6115.260964630428 5270.691609340099 5215.304348712256 5375.694925738402 5509.780614447822 0.9000924061373354 1.0347876434570318 1.1705666781745319 1.3186502695029882 0.9954771003682913 1.1098919163124041 0.9566064382888892 0.9465539036230615 0.9756640603152477 1.0 12.427779160128333 -7.262916404440852 24.474368211480446 0.9652522518652799 1.095812717699898 0.23355229285864276 0.10453749637800587 152.05410268012923 2519494.4239732814 0.04510168106297191 0.03229198388020813 5.458629218890147e-08 7.262916404440852 0.1305604658346181 SSQPSPT(ph)AVPASDS(ph)PPTKQEVK ddPTM_A459_Selumetinib_30min_R2 1 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 2 S(0.001)S(0.001)QPS(0.263)PT(0.734)AVPAS(0.07)DS(0.86)PPT(0.07)KQEVK 86.258 0.0019889 40014000.0 103580.0 113000.0 107080.0 116960.0 98276.0 75080.0 86532.0 86649.0 59178.0 117620.0 True False 97823.43826359295 121666.73664773194 100190.58937988884 101029.84623274615 85929.69028141277 85421.58849161874 90555.90945990509 86901.13424448589 71015.25357147287 114224.00498653912 0.8564175128960071 1.065159085098355 0.8771412750909577 0.8844887398638503 0.7522909942751461 0.7478427017305632 0.7927922810146324 0.7607957211334594 0.6217191699751883 1.0 16.80150634961843 -5.957101130564204 1.8453390273606998 0.7659602503747855 0.9553712094259903 0.31711458691860006 0.1019111148226086 0.3506452465591467 2.4152577223941796 0.03124200401266802 0.05275429845174984 1.103821552176828e-06 5.957101130564204 0.18941095905120475 SSQPSPT(ph)AVPASDSPPTK ddPTM_A459_Selumetinib_30min_R1 1 SSQPSPTAVPASDSPPTK 18 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 S(0.001)SQPS(0.147)PT(0.852)AVPASDSPPTK 211.67 2.0805e-11 25574000.0 10090.0 15902.0 12254.0 14426.0 13313.0 13273.0 13591.0 11725.0 6664.8 10626.0 True False 10325.077368277709 14040.186447360766 10589.97410640385 11906.769909558285 12108.841500601058 13139.485670919767 12565.81992782312 11414.01491183245 11309.67882226754 11989.950606005023 0.8611442788685483 1.1709961874512567 0.883237509010253 0.9930624654612774 1.0099158785972389 1.0958748791124304 1.048029332291801 0.9519651320428191 0.9432631704590363 1.0 13.549538094963939 -4.506697690069108 18.59449711447128 1.0089198389214575 0.5656986762853581 0.25400042366284203 0.07683890359178384 5686267.927108962 144542502.1679508 0.018801346305877906 70338296.79382789 3.11388313929889e-05 4.506697690069108 -0.44322116263609945 SSQPSPTAVPAS(ph)DSPPTKQEVK ddPTM_A459_Selumetinib_30min_R1 1 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 SSQPS(0.007)PT(0.332)AVPAS(0.343)DS(0.291)PPT(0.027)KQEVK 62.792 0.005626600000000001 14872000.0 1351.1 2336.7 2341.6 2862.7 1728.7 1935.3 1647.7 1834.2 942.88 1268.1 True False 1382.5780012170476 2063.118077697642 2023.6235814881045 2362.7831845343485 1572.3393902267744 1915.8326391118057 1523.4126624291196 1785.5510576787283 1599.9984947694766 1430.872987340012 0.966247887443354 1.441859687024333 1.4142580084973255 1.65128785394625 1.09886719795427 1.3389257160227281 1.0646735775347458 1.2478752995386835 1.1181974283712408 1.0 10.482679900355455 -6.862874718114428 1.5372035568169327 1.1312314145564493 1.361417986230816 0.21471274840573829 0.1875277329489215 0.6190867526917473 3.022702609163431 0.08714263404439208 0.07272419222977533 1.3712772844920915e-07 6.862874718114428 0.23018657167436674 SSQPSPTAVPAS(ph)DSPPTKQEVK ddPTM_A459_Selumetinib_30min_R2 1 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 SSQPS(0.003)PT(0.007)AVPAS(0.428)DS(0.428)PPT(0.133)KQEVK 46.368 0.043897000000000005 12715000.0 23103.0 22191.0 25590.0 24937.0 24207.0 19911.0 20356.0 17623.0 15940.0 24929.0 True False 21819.027748636676 23892.97834468873 23943.567260285345 21540.537581275577 21165.900246674264 22653.55951593792 21302.594334648773 17674.28001235529 19128.445400812412 24209.234996679406 0.9012687824142078 0.986936528476259 0.9890261820982571 0.8897653141138134 0.8742903379465492 0.9357404114192428 0.8799366992625205 0.730063548673865 0.7901301054509204 1.0 14.563269870950139 -6.804451484650593 0.9949110439532853 0.8299629497673866 0.9510948392195682 0.19270055043878564 0.07454207252020544 0.7061404250656232 1.4941513482907982 0.04443510279542151 0.038762631312315006 1.5687311319770868e-07 6.804451484650593 0.12113188945218156 SSQPSPTAVPASDS(ph)PPTK ddPTM_A459_Selumetinib_30min_R1 1 SSQPSPTAVPASDSPPTK 18 0 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 SSQPSPTAVPAS(0.003)DS(0.993)PPT(0.004)K 126.25 0.0009319 0.0 1662.2 2127.2 1505.1 1493.6 1499.4 1765.7 1431.2 1296.5 613.91 1363.3 True False 1700.9260259218254 1878.1464350915483 1300.7156869225091 1232.7707983443968 1363.7795347405702 1747.9386611273278 1323.24343173427 1262.112608374479 1041.7604317876396 1538.2928346665403 1.1057231676506765 1.2209290667980515 0.8455579182389343 0.8013888972002055 0.886553914837808 1.1362847318379616 0.8602025582607051 0.8204631653556849 0.677218542731797 1.0 10.587114450450217 -5.264495843665341 24.99747074978927 0.8781393677104672 1.1633261298612003 0.4826630236129197 0.11796851204976533 214.9079046790878 1757652.1320612596 0.03231483878955113 0.07219145751778977 5.438813368107961e-06 5.264495843665341 0.28518676215073313 SSQPSPTAVPASDS(ph)PPTKQEVK ddPTM_A459_Selumetinib_30min_R2 3 SSQPSPTAVPASDSPPTKQEVK 22 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;C9JIR3;E9PLH3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 SSQPSPTAVPASDS(0.939)PPT(0.06)KQEVK;SSQPSPTAVPAS(0.08)DS(0.908)PPT(0.012)KQEVK;SSQPS(0.001)PT(0.063)AVPAS(0.02)DS(0.884)PPT(0.032)KQEVK 135.63 9.3062e-06 35943500.0 107629.0 110136.0 114242.0 115695.0 108156.0 85421.0 81233.0 91937.0 65056.0 109394.0 True False 101647.41105302409 118583.0770569439 106891.79409728484 99937.141414993 94568.47635309212 97186.96737536706 85010.4954601358 92204.52144901038 78069.01781651509 106235.5109802538 0.9568119936084035 1.116228236328483 1.0061776247035987 0.9407131428357182 0.8901776391010134 0.9148256216645995 0.8002079029481663 0.867925617321581 0.7348674383561437 1.0 16.69690656592411 -6.095475161490538 1.1953299611425219 0.8482139244144101 1.0442086874731904 0.47504828737112315 0.07469758196394878 0.3697425627692196 1.0789633473000484 0.027919427190438932 0.048626618136413224 8.026474652011114e-07 6.095475161490538 0.19599476305878027 SSQQPST(ph)PQQAPPGQPQQGTFVAHK ddPTM_A459_Selumetinib_30min_R1 2 SSQQPSTPQQAPPGQPQQGTFVAHK 25 0 E7ERS3;Q86VM9;H3BRH3 E7ERS3;H3BRH3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 S(0.019)S(0.019)QQPS(0.217)T(0.745)PQQAPPGQPQQGTFVAHK;S(0.002)S(0.002)QQPS(0.249)T(0.746)PQQAPPGQPQQGTFVAHK 184.31 4.4157999999999996e-21 29961000.0 3678.9 3588.6 4049.2000000000003 4647.5 3377.7 3599.1000000000004 3539.3999999999996 3291.1 1766.6 3049.7 True False 3764.6112121067276 3168.445043705122 3499.340880663491 3835.901369379739 3072.187631381368 3562.8963217213372 3272.420208412712 3203.8093370005795 2997.791172641012 3441.158701593591 1.093995232002333 0.9207494679736287 1.016907729086414 1.1147121368169808 0.8927770840556254 1.0353769269843236 0.9509646291225288 0.9310263242194858 0.8711574886833157 1.0 11.748678713418863 -7.1944482386659425 1.1428733125324113 0.9257685073080555 1.0158534976952587 0.20493527637925757 0.0702669376128811 0.7950933054384968 2.04874578510317 0.045260868074201356 0.027291269198932485 6.390749008723559e-08 7.1944482386659425 0.09008499038720319 SSQQPST(ph)PQQAPPGQPQQGTFVAHK ddPTM_A459_Selumetinib_30min_R2 4 SSQQPSTPQQAPPGQPQQGTFVAHK 25 0 E7ERS3;Q86VM9;H3BRH3 E7ERS3;H3BRH3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 S(0.075)S(0.075)QQPS(0.256)T(0.594)PQQAPPGQPQQGTFVAHK;S(0.005)S(0.005)QQPS(0.232)T(0.757)PQQAPPGQPQQGTFVAHK;S(0.083)S(0.083)QQPS(0.202)T(0.631)PQQAPPGQPQQGTFVAHK;S(0.032)S(0.032)QQPS(0.246)T(0.69)PQQAPPGQPQQGTFVAHK 156.49 1.0776e-12 90506000.0 309153.0 283408.0 349182.0 343210.0 336006.0 310223.0 302989.0 304665.0 261012.0 332637.0 True False 291971.51389751415 305144.48229964974 326716.0102806157 296464.205929727 293793.92234824726 352953.40232599096 317078.58886131353 305551.5247099941 313221.6932846209 323032.9055152817 0.9038444966830225 0.9446235262407788 1.0114016395929044 0.9177523430835196 0.9094860533777688 1.0926236810549748 0.9815674609233067 0.9458835910929804 0.9696278240911383 1.0 18.301321605937282 SSQSEGIFLGS(ph)ESDEDSVR ddPTM_A459_Selumetinib_30min_R2 1 SSQSEGIFLGSESDEDSVR 19 0 Q9BYW2;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 SSQSEGIFLGS(0.641)ES(0.062)DEDS(0.297)VR 101.89 0.002774 0.0 3267.5 3922.6 2329.8 3177.7 2799.6 1178.7 3086.1 1635.8 3167.4 2693.7 True False 3085.905430838867 4223.450806853046 2179.9032044944433 2744.891778161745 2447.889219258447 1341.055225826731 3229.609764991137 1640.5599071787317 3800.968504550392 2615.9258819268834 1.179660881127793 1.614514706258445 0.8333199421111782 1.0493002868031818 0.9357639817590471 0.5126503144037527 1.2345952870087495 0.6271431153738576 1.453010779399686 1.0 11.353105949622183 -5.270102093333705 24.9323047717596 0.9391715673916537 1.3970878013037897 0.29151396453886935 0.27425930521254405 603.8417777512366 1737930.3043335418 0.066735978455221 0.14245505120471397 5.369055665312465e-06 5.270102093333705 0.457916233912136 SSQTGTEPGAAHTS(ph)SPQPSTSR ddPTM_A459_Selumetinib_30min_R1 5 SSQTGTEPGAAHTSSPQPSTSR 22 0 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;H0YE34 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 SSQTGTEPGAAHTS(0.492)S(0.492)PQPS(0.006)T(0.006)S(0.006)R;SSQTGTEPGAAHT(0.01)S(0.376)S(0.376)PQPS(0.079)T(0.079)S(0.079)R;SSQTGTEPGAAHT(0.127)S(0.436)S(0.436)PQPSTSR;SSQTGTEPGAAHT(0.011)S(0.492)S(0.492)PQPS(0.001)T(0.001)S(0.001)R;SSQTGTEPGAAHT(0.034)S(0.475)S(0.475)PQPS(0.012)T(0.004)S(0.001)R 176.68 3.1766e-16 10092500.0 2320.78 2589.0699999999997 2147.6800000000003 2696.28 3338.44 2128.0899999999997 2678.94 1958.98 825.01 1591.0910000000001 True False 2374.8496585482194 2285.940480774013 1856.0368523617933 2225.425313444047 3036.4786914494543 2106.68334675112 2476.865398973031 1907.0214867361656 1399.9817136536644 1795.323028388777 1.3227979706134232 1.2732753073554364 1.0338177715168642 1.2395681881501113 1.6913272115573317 1.1734285771635065 1.3796210263040565 1.0622163569347367 0.7797937705450624 1.0 10.8100277329032 -7.958418326545796 4.286052737879949 0.8941470828647815 1.2970437458494226 0.5048309351571412 0.16642732688040854 0.17241106309346416 6.883982928893335 0.10678141414074978 0.04582635835102028 1.1004787819625942e-08 7.958418326545796 0.4028966629846411 SSQTGTEPGAAHTS(ph)SPQPSTSR ddPTM_A459_Selumetinib_30min_R2 2 SSQTGTEPGAAHTSSPQPSTSR 22 0 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;H0YE34 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 SSQTGTEPGAAHTS(0.747)S(0.231)PQPS(0.007)T(0.007)S(0.007)R;SSQTGTEPGAAHT(0.001)S(0.384)S(0.384)PQPS(0.048)T(0.048)S(0.135)R 171.87 3.0094e-12 4490100.0 5250.799999999999 4086.7 10247.7 15961.3 19121.9 10556.4 8884.2 8420.7 8688.0 10434.900000000001 True False 4958.981556617815 4400.136749188381 9588.37413885214 13787.343405221718 16719.635970045056 12010.448278541866 9297.33290370833 8445.202842878074 10425.842763002403 10133.617323873801 0.4893594654432968 0.4342118523483311 0.9461946146577764 1.3605549691263847 1.6499178364131875 1.1852083905168234 0.9174742450363437 0.8333848193558692 1.028837228581757 1.0 13.306861634010641 -5.373449742932007 3.6526151333139887 1.1467427510708446 0.4581196178869022 0.5894069726290612 0.22229131517863424 0.18037287627780593 4.308845615668481 0.06950212993293328 0.16129958650731482 4.232044806030825e-06 5.373449742932007 -0.6886231331839423 SSQTGTEPGAAHTSS(ph)PQPSTSR ddPTM_A459_Selumetinib_30min_R1 1 SSQTGTEPGAAHTSSPQPSTSR 22 0 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;H0YE34 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 SSQTGTEPGAAHT(0.002)S(0.193)S(0.593)PQPS(0.07)T(0.07)S(0.07)R 128.55 1.7805e-05 1053600.0 184.86 0.0 163.46 184.96 126.94 172.21 218.41 190.07 121.87 103.29 True False 189.1668783250562 0.0 141.26302982150912 152.66020812920425 115.45829941307726 170.47772375416952 201.93515785710017 185.02872616562846 206.80448896737258 116.5482776298004 1.6230774248412216 0.0 1.2120559196096552 1.3098452524035442 0.9906478393427203 1.4627219485445218 1.7326309917553606 1.5875715191034123 1.7744105118761055 1.0 6.864783874007216 -6.374387642458504 1.022096589251933 1.573906772440098 0.8648736414489886 0.20792713699227872 0.44498279392112305 0.6875306590212986 1.5270145242439264 0.20411192834243042 0.2784487105179817 4.2229151714075057e-07 6.374387642458504 -0.7090331309911093 SSRFS(ph)GGFGAR ddPTM_A459_Selumetinib_30min_R1 1 SSRFSGGFGAR 11 1 A0A2R8Y645;A0A2U3TZJ9;O00571;O00571-2;A0A0D9SG12;A0A2R8YF78;A0A0D9SF53;F6S8Q4;A0A0D9SFB3;A0A2R8Y7T2;A0A087WVZ1 A0A2R8Y645 DDX3X ATP-dependent RNA helicase DDX3X 1 S(0.089)S(0.089)RFS(0.823)GGFGAR 124.39 0.017033 29320000.0 4477.9 3689.6 6689.8 7039.3 5508.2 4161.0 4123.1 4089.0 2658.5 2775.9 True False 4582.2263575233665 3257.619916751495 5781.3619044410325 5810.018399026314 5009.984282551693 4119.144117885717 3812.091247473148 3980.546437056112 4511.2803308423745 3132.2138045557444 1.4629353688623066 1.0400375325635018 1.8457749902104874 1.8549239488619054 1.599502650574098 1.315090340223423 1.217059717292777 1.2708412277816044 1.4402849269998121 1.0 11.61296697885059 -6.838885535456189 4.867810839505352 1.25719141680764 1.5637435326167786 0.3075265074493386 0.23503959004744543 0.3103392367645708 13.308549111647391 0.0910425329276608 0.0809273890453814 1.4491537484846425e-07 6.838885535456189 0.30655211580913866 SSRS(ph)SPELTR ddPTM_A459_Selumetinib_30min_R1 1 SSRSSPELTR 10 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.007)S(0.007)RS(0.785)S(0.2)PELTR 77.74 0.029838 25621000.0 444.7 327.24 1528.6 1705.7 933.75 641.6 577.52 505.59 370.23 217.45 True False 455.06064476442964 288.9265886702513 1321.0245159987683 1407.8315149544974 849.292477366952 635.14608652619 533.9572014359803 492.18011081222784 628.2532694706686 245.36182564236702 1.8546513646654803 1.1775531418297447 5.383985518286202 5.7377773061018695 3.4613879936027967 2.5886100450359475 2.1762032461164615 2.0059359662966343 2.5605175859198 1.0 7.938766996067574 -6.9045248911915715 2.9667442002308033 2.0425464037876973 3.621283664057494 0.2355709693910666 1.3440713641133073 0.459354268724705 8.144028710803607 0.5818083889289912 0.4992603337602848 1.2458768289318744e-07 6.9045248911915715 1.5787372602697967 SSS(ph)APLIHGLSDLSQVFQPYTLR ddPTM_A459_Selumetinib_30min_R1 1 SSSAPLIHGLSDLSQVFQPYTLR 23 0 G1UD79;Q7Z309-4;Q7Z309-3;Q7Z309-2;Q7Z309 G1UD79;Q7Z309-2 SPACIA2;FAM122B Protein FAM122B 1 S(0.039)S(0.039)S(0.921)APLIHGLSDLSQVFQPYTLR 136.88 3.1514e-06 24076000.0 2747.2 2900.9 3259.1 3467.9 3738.1 3034.5 3285.6 2935.7 1303.3 2120.1 True False 2811.2044148793366 2561.261279408178 2816.532120954851 2862.296365545347 3399.989515015158 3003.975685105555 3037.764546748263 2857.835699502476 2211.6049107341983 2392.2354865227967 1.175136992456176 1.0706560009821886 1.1773640750763987 1.1964944010197762 1.4212603793271077 1.2557190552640558 1.269843443031508 1.1946297576483353 0.9244929787196027 1.0 11.22414369698936 -8.213900663414453 5.706600188835024 0.9620416136621842 1.2236761243900183 0.5894025128162886 0.08617453715930296 0.1414944771053092 11.320009775080022 0.06975650909055765 0.024642072454126605 6.110817822326708e-09 8.213900663414453 0.26163451072783406 SSS(ph)APNVHINTIEPVNIDDLIR ddPTM_A459_Selumetinib_30min_R1 5 SSSAPNVHINTIEPVNIDDLIR 22 0 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056;A0A2R8Y679;A0A2R8Y492;A0A2R8YDP5 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 S(0.174)S(0.174)S(0.651)APNVHINTIEPVNIDDLIR;S(0.12)S(0.12)S(0.761)APNVHINTIEPVNIDDLIR;S(0.19)S(0.094)S(0.717)APNVHINTIEPVNIDDLIR;S(0.132)S(0.15)S(0.718)APNVHINTIEPVNIDDLIR;S(0.027)S(0.027)S(0.946)APNVHINTIEPVNIDDLIR 145.52 3.138e-07 126152400.0 9669.0 10559.439999999999 10216.550000000001 10463.43 11716.9 9293.0 9969.6 9308.34 4425.16 8032.870000000001 True False 9894.268887401104 9323.135855849521 8829.198625492098 8636.18837340701 10657.108463786708 9199.520857368898 9217.58504542899 9061.452585450445 7509.17331910116 9063.967111279844 1.0916046766197962 1.0285933015188404 0.9740987050255749 0.9528044693211127 1.1757664533584027 1.0149552336658814 1.0169482007451212 0.9997225799919033 0.8284643166628674 1.0 13.145926910992674 -8.05500274173112 6.9225714457872485 0.9128789242210209 1.0332913131222203 0.3212721148040294 0.07002642681705554 0.29755678482253045 31.012399322186937 0.04703878071136871 0.017819863841361517 8.810433109030637e-09 8.05500274173112 0.12041238890119943 SSS(ph)APNVHINTIEPVNIDDLIR ddPTM_A459_Selumetinib_30min_R2 4 SSSAPNVHINTIEPVNIDDLIR 22 0 H7C560;A0A2R8Y8E0;A0A2U3TZI2;P15056;A0A2R8Y679;A0A2R8Y492;A0A2R8YDP5 H7C560 BRAF Serine/threonine-protein kinase B-raf 1 S(0.127)S(0.127)S(0.745)APNVHINT(0.001)IEPVNIDDLIR;S(0.149)S(0.149)S(0.702)APNVHINT(0.001)IEPVNIDDLIR;S(0.114)S(0.114)S(0.773)APNVHINTIEPVNIDDLIR;S(0.033)S(0.033)S(0.935)APNVHINTIEPVNIDDLIR 136.33 1.0385e-05 55149300.0 40059.4 36228.0 43224.1 47959.0 46969.5 37196.1 34682.8 39328.4 33534.7 44248.4 True False 37833.05891848399 39006.57110861986 40443.10846484175 41426.90146611043 41068.771497342335 42319.52514242271 36295.61892266443 39442.83913283291 40242.5770378058 42970.83372084998 0.8804357663678963 0.9077452711766536 0.9411757921098528 0.9640702280814623 0.9557359711504797 0.9848430081050243 0.8446570796938795 0.9178979255805026 0.9365091052045287 1.0 15.391070148126678 -5.018269758100412 2.7380856355634364 0.939304528886176 0.8805630771150842 0.20199770066309397 0.04011999159087733 0.5490035130545304 7.483164377714728 0.01098331597772975 0.057196755165299915 9.588048935045674e-06 5.018269758100412 -0.0587414517710918 SSS(ph)ASSPEMK ddPTM_A459_Selumetinib_30min_R1 5 SSSASSPEMK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SS(0.002)S(0.995)AS(0.003)SPEMK;SS(0.002)S(0.998)ASSPEMK;SSS(0.983)AS(0.017)SPEMK;S(0.059)S(0.059)S(0.877)AS(0.004)S(0.001)PEMK;S(0.003)S(0.004)S(0.947)AS(0.037)S(0.01)PEMK 141.1 0.0013805999999999998 133217000.0 25419.0 30056.399999999998 32703.7 32730.699999999997 30074.700000000004 28077.3 29783.8 29271.799999999996 19061.7 22950.9 True False 26011.213243235998 26537.38271515872 28262.717168565327 27014.897676332952 27354.44869511954 27794.86785414869 27537.18398692506 28495.41677579335 32346.312688515354 25896.871575697416 1.0044152695125492 1.02473314730658 1.091356424499093 1.0431722456269479 1.0562839073114132 1.0732905622558837 1.0633401763001742 1.1003420506797625 1.2490432519606087 1.0 14.660490205846205 -7.869024284246302 3.8051878020273433 1.1380781937886593 1.052003770520973 0.19179918958733155 0.06073616670285967 0.2980341056705015 8.007747595493152 0.03453603003458329 0.015388961177640426 1.3519969620836395e-08 7.869024284246302 -0.08607442326768622 SSS(ph)ASSPEMK ddPTM_A459_Selumetinib_30min_R2 5 SSSASSPEMK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SS(0.002)S(0.997)AS(0.001)SPEMK;SS(0.024)S(0.976)ASSPEMK;SS(0.014)S(0.985)ASSPEMK;SS(0.004)S(0.973)AS(0.021)S(0.001)PEMK;SS(0.004)S(0.995)AS(0.001)SPEMK 169.65 0.00022878 115601800.0 341967.0 273528.0 271726.0 334512.0 304387.0 229757.0 301011.0 310361.0 262528.0 348963.0 True False 322961.8431423636 294506.71806885797 254243.44499289914 288950.8885346132 266147.18380569434 261403.9412236124 315008.607941981 311264.0991269709 315040.9356451997 338887.5314752399 0.9530059773413649 0.8690396981760171 0.7502295640271288 0.852645381424205 0.7853554913841373 0.77135898180046 0.9295373204516864 0.9184879059196451 0.9296327140563962 1.0 18.370447031855498 -7.352677534131109 7.059678915384716 0.9388149598155228 0.8275129454531821 0.4832296326794343 0.057703188909127956 0.2577058525167945 17.239483126691606 0.02534122772165687 0.016999660349123032 4.4393814792721764e-08 7.352677534131109 -0.11130201436234066 SSS(ph)CGSGGGGISPK ddPTM_A459_Selumetinib_30min_R1 1 SSSCGSGGGGISPK 14 0 F5GWH4;Q96EP1-2;Q96EP1-4;Q96EP1;F5H375 F5GWH4 CHFR E3 ubiquitin-protein ligase CHFR 1 S(0.141)S(0.141)S(0.718)CGSGGGGISPK 172.85 1.2009e-09 0.0 1891.8 2500.3 2470.8 2475.9 1943.4 1925.3 2404.2 1787.6 1204.1 1961.1 True False 1935.8752591979944 2207.563713642066 2135.2789311329057 2043.530543399096 1767.6198131351373 1905.933230032534 2222.8492583674742 1740.18704105686 2043.2697560155352 2212.826287731643 0.8748428513936584 0.9976217861660657 0.9649555154741809 0.9234934322358891 0.7988064056067933 0.8613117263652433 1.0045294882347524 0.7864092408449815 0.9233755796122979 1.0 11.111674485161725 -6.00618896708652 24.199723605872627 0.8862658023615924 0.949860954428935 0.07660367964596959 0.07394507836833066 380.63498112994984 1488357.198911052 0.02049941352418558 0.029259367220645437 9.85850436155327e-07 6.00618896708652 0.06359515206734268 SSS(ph)CGSGGGGISPK ddPTM_A459_Selumetinib_30min_R2 2 SSSCGSGGGGISPK 14 0 F5GWH4;Q96EP1-2;Q96EP1-4;Q96EP1;F5H375 F5GWH4 CHFR E3 ubiquitin-protein ligase CHFR 1 S(0.001)S(0.016)S(0.983)CGSGGGGISPK;SS(0.04)S(0.959)CGSGGGGISPK 176.87 6.9768e-05 3999200.0 43010.0 37471.0 41542.0 44399.0 45445.0 34566.0 33871.0 38882.0 30965.0 43365.0 True False 40619.67638267162 40344.90521174491 38869.232947509714 38351.77960745295 39735.79281654528 39327.152741093385 35446.06861411324 38995.14018273838 37158.86523438875 42112.939774198814 0.964541459239517 0.958016833497406 0.9229760058528041 0.9106887292382707 0.9435530511429665 0.9338496184773074 0.841690672847063 0.9259657575990312 0.8823621773646575 1.0 15.3619759686547 -7.0328040243285574 24.98100619020832 0.9036829911113902 0.9384206454569302 0.07888291230930511 0.040213626623914 1237.956199214838 942727.6351372628 0.014607509702225121 0.01132379038245173 9.272481503265923e-08 7.0328040243285574 0.03473765434553999 SSS(ph)DMDLQK ddPTM_A459_Selumetinib_30min_R1 1 SSSDMDLQK 9 0 A0A0U1RQE4;Q5HYK7-2;Q5HYK7;Q5HYK7-3;A0A494C1M0 A0A0U1RQE4;A0A494C1M0 SH3D19 SH3 domain-containing protein 19 1 S(0.022)S(0.022)S(0.956)DMDLQK 150.15 0.0013502 6116500.0 3232.8 3194.0 2370.1 2374.6 2218.7 2724.7 2678.2 2981.0 1646.0 2545.7 True False 3308.117950066221 2820.044995149685 2048.2534380273996 1959.9206867625894 2018.018976743301 2697.29199182966 2476.1812177688093 2901.9341963473385 2793.1417809165114 2872.465392217862 1.1516650327724183 0.9817507298050674 0.7130646181418119 0.6823130722731923 0.7025390043725354 0.9390163582604738 0.862040400722434 1.0102590632455708 0.9723848330718777 1.0 11.488073795888067 -7.727418210568344 6.210736216930357 0.9937621150387838 0.8499536918072247 0.1618609827416574 0.1363076687729171 0.33914334252384637 37.03908167407253 0.07457972639867487 0.041162998579703715 1.8731898222571786e-08 7.727418210568344 -0.14380842323155907 SSS(ph)DSWEPTSAGSK ddPTM_A459_Selumetinib_30min_R1 1 SSSDSWEPTSAGSK 14 0 A0A3B3IRS8;B1AL16;Q8IX21;Q8IX21-2 A0A3B3IRS8 FAM178A Protein FAM178A 1 SS(0.009)S(0.987)DS(0.003)WEPTSAGSK 184.0 7.7708e-05 6784200.0 4094.3 5330.4 5360.8 5959.4 5435.8 4565.8 5177.3 5038.9 2854.3 3949.3 True False 4189.689223879033 4706.314289964267 4632.832804766586 4918.7026617927095 4944.132849768439 4519.872197414709 4786.772092731857 4905.252003346055 4843.538630176183 4456.2311244396415 0.9401866974316497 1.0561198821472872 1.0396302784562486 1.1037808687293396 1.109487526949166 1.0142813671907716 1.0741750055286416 1.100762475367091 1.0869136934151378 1.0 12.121608345310339 -4.211400776991502 1.496748007916526 1.07183395814072 0.5522589682420671 0.5146907005994958 0.036111700528096286 4.26639529162802 2.6769805588880113 0.009977246809856717 5.019999787102261 6.146094351275305e-05 4.211400776991502 -0.5195749898986528 SSS(ph)EDAESLAPR ddPTM_A459_Selumetinib_30min_R1 1 SSSEDAESLAPR 12 0 Q4G0J3;Q4G0J3-3;H0YA82 Q4G0J3 LARP7 La-related protein 7 1 S(0.366)S(0.051)S(0.582)EDAESLAPR 234.79 1.332e-10 78306000.0 2099.2 2403.1 3067.8 2960.6 2624.9 2441.0 2775.6 2712.9 1384.1 1890.3 True False 2148.107275667847 2121.743934829118 2651.2096102191686 2443.586787344952 2387.4782584637355 2416.445756250668 2566.2342573516185 2640.94507925887 2348.716609335687 2132.938418081244 1.0071117184903295 0.9947516144126674 1.2429846017796204 1.14564338408943 1.1193376415487286 1.132918670209177 1.2031450301599238 1.2381722120391176 1.1011647544182515 1.0 11.058626597639526 -5.241447732991897 24.664667773706796 1.156761278466847 1.0009316128086105 0.4243442094862193 0.06785847284114785 584.9725329053206 721705.6653580348 0.016509282921114112 0.04355024627442911 5.7352488567318745e-06 5.241447732991897 -0.15582966565823653 SSS(ph)EITLSECDAEDAGEPR ddPTM_A459_Selumetinib_30min_R1 5 SSSEITLSECDAEDAGEPR 19 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 SS(0.001)S(0.999)EITLSECDAEDAGEPR;S(0.023)SS(0.976)EITLSECDAEDAGEPR;SSS(1)EITLSECDAEDAGEPR;SSS(1)EITLSECDAEDAGEPR;S(0.004)S(0.007)S(0.989)EITLSECDAEDAGEPR 413.48 0.0 198821500.0 7344.26 9013.15 8927.279999999999 9473.690000000002 9553.189999999999 7933.5 8332.83 7904.34 5133.48 6854.52 True False 7515.366968557703 7957.886207900244 7715.004410038915 7819.287884686209 8689.105651252687 7853.696193041656 7704.277924300076 7694.691226285174 8711.140625455218 7734.364410678857 0.9716851404339336 1.0288998274910308 0.9974968853790738 1.0109800197531549 1.1234414607172654 1.0154287768233468 0.9961100247180957 0.9948705307524809 1.1262904309793995 1.0 12.917067024398797 -6.022494315825685 24.92653202021766 1.041329746720125 1.0026351696017863 0.15192425802591747 0.047134997805949055 1561.9837681594545 1730876.4911785773 0.013988897367194858 0.018202839407162004 9.495234267636313e-07 6.022494315825685 -0.03869457711833868 SSS(ph)EITLSECDAEDAGEPR ddPTM_A459_Selumetinib_30min_R2 5 SSSEITLSECDAEDAGEPR 19 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 SS(0.001)S(0.998)EITLSECDAEDAGEPR;S(0.156)S(0.156)S(0.681)EIT(0.007)LS(0.001)ECDAEDAGEPR;SS(0.001)S(0.999)EITLSECDAEDAGEPR;SS(0.012)S(0.988)EITLSECDAEDAGEPR;SS(0.001)S(0.999)EITLSECDAEDAGEPR 443.18 0.0 318087600.0 84323.0 77224.0 92549.0 108240.0 100495.0 77864.0 78255.7 77049.7 68621.0 85856.0 True False 79636.66523171398 83146.83248570343 86594.49809973207 93497.52527558504 87869.91966330113 88589.05922098302 81894.74511072774 77273.90187073553 82347.1174309378 83377.11419932249 0.9551381814598844 0.9972380704725694 1.0385883336369506 1.1213811628460606 1.0538853557972525 1.062510499094521 0.9822209115435325 0.9267999092173359 0.9876465289273221 1.0 16.347363818829656 -7.386146650264433 5.1659449877490875 0.9656820807785493 1.0405639432037193 0.3313608101218145 0.044267960169557787 0.26956926006583476 10.220813477637677 0.020812958837301453 0.013770965139048583 4.110109096784176e-08 7.386146650264433 0.07488186242516992 SSS(ph)ESTSSTVNGVPSR ddPTM_A459_Selumetinib_30min_R1 1 SSSESTSSTVNGVPSR 16 0 Q9NR48-2;Q9NR48 Q9NR48-2 ASH1L Histone-lysine N-methyltransferase ASH1L 1 S(0.001)S(0.005)S(0.991)ES(0.004)TSSTVNGVPSR 164.63 2.3185e-05 2958300.0 1033.0 1263.5 1350.3 1158.6 1205.8 1173.5 1139.9 1337.1 789.2 1017.0 True False 1057.0668901319004 1115.5688326147865 1166.9366766669748 956.2722596155708 1096.7356029012808 1161.6956554527496 1053.9164252612456 1301.6357644870936 1339.2147591125827 1147.5418564188885 0.921157589345515 0.9721378147339396 1.0169011876469685 0.8333223352739315 0.9557260127520247 1.0123340154911915 0.9184121863320803 1.1342817320398952 1.1670291167346558 1.0 10.164331061348369 -7.763466647166696 24.999975902241363 1.1129916060344405 0.9492459462310238 0.5470575682595717 0.0635938428903423 37.9787183291179 468324.1590318164 0.03222509446412602 0.01669812823545056 1.7239844840497622e-08 7.763466647166696 -0.1637456598034167 SSS(ph)ESYTQSFQSR ddPTM_A459_Selumetinib_30min_R1 2 SSSESYTQSFQSR 13 0 Q9BTU6;E9PAM4 Q9BTU6 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 1 S(0.31)S(0.039)S(0.65)ESYTQSFQSR;S(0.027)S(0.057)S(0.911)ES(0.004)YT(0.001)QSFQSR 302.85 3.595399999999998e-74 53404000.0 6000.0 4059.3999999999996 5993.700000000001 3804.5 5252.0 5039.2 4696.9 6403.200000000001 2831.2 4258.9 True False 6139.788326032333 3584.123560836137 5179.788461037434 3140.1154943098936 4776.95752731591 4988.510223227516 4342.609051504117 6233.3663354751025 4804.339617333429 4805.571300199018 1.277639627525256 0.7458267367061444 1.0778715240002616 0.6534322972546155 0.9940457083881112 1.0380680904725983 0.9036613505920247 1.2971124443033346 0.9997436968908279 1.0 12.2304922376111 -7.715401606441333 24.999769753027504 1.1113232852978445 0.9454183822095643 0.1140032846687653 0.1802943238693069 218.9303940965993 118884.87648695127 0.08004133523660233 0.04621166773949605 1.9257432911749276e-08 7.715401606441333 -0.1659049030882802 SSS(ph)ETILSSLAGSDIVK ddPTM_A459_Selumetinib_30min_R1 1 SSSETILSSLAGSDIVK 17 0 Q01850 Q01850 CDR2 Cerebellar degeneration-related protein 2 1 SS(0.018)S(0.982)ETILSSLAGSDIVK 373.51 4.066999999999995e-222 63397000.0 1817.7 1597.4 2420.7 2449.1 2277.4 1926.3 1907.4 1891.5 1077.9 1523.2 True False 1860.0488733714953 1410.3756653888868 2091.9822359533027 2021.4106603007892 2071.409572107626 1906.9231709404614 1763.523282343451 1841.331275542096 1829.1175732988513 1718.7175572244355 1.0822306815642802 0.8205976947524226 1.2171762760902112 1.176115675204467 1.2052065002773082 1.1095035149463184 1.0260692776021747 1.0713402372613623 1.0642339490920785 1.0 10.74711676591145 -10.623834015601421 14.615954957838229 1.000004217028413 1.0865714900191525 0.054549530361530874 0.10715796357638793 0.0 0.0 0.10947209228151233 0.02655088232553172 2.3777488724408793e-11 10.623834015601421 0.08656727299073963 SSS(ph)ETILSSLAGSDIVK ddPTM_A459_Selumetinib_30min_R2 3 SSSETILSSLAGSDIVK 17 0 Q01850 Q01850 CDR2 Cerebellar degeneration-related protein 2 1 S(0.004)S(0.017)S(0.979)ETILSSLAGSDIVK;S(0.02)S(0.028)S(0.952)ETILSSLAGSDIVK;S(0.101)S(0.203)S(0.696)ETILSSLAGSDIVK 259.29 3.7777e-40 28382700.0 124818.0 111709.0 137120.0 155965.0 133860.0 109127.0 120783.0 118108.0 99017.0 123429.0 True False 117881.1152460431 120276.72109895152 128297.84848496811 134722.29794536802 117043.31007641653 124158.2536937251 126399.64882697418 118451.67472616794 118823.16676613805 119865.28406294453 0.983446676555161 1.0034324953986755 1.0703503477920715 1.1239475966587762 0.9764571201028807 1.0358149539655386 1.0545142391736901 0.9882066826285227 0.9913059289438697 1.0 16.87105435368617 -7.772573707270737 24.927693555367338 0.992317210296591 1.0366881846456013 0.18270184674143441 0.04087933862210017 386.44909830839265 865173.6553046731 0.023349028228776932 0.011389641568735212 1.6882093169074577e-08 7.772573707270737 0.04437097434901027 SSS(ph)FGSVSTSSNSSK ddPTM_A459_Selumetinib_30min_R1 4 SSSFGSVSTSSNSSK 15 0 E5RG30;E5RJ65;E5RHF1;E5RGS8;E5RH07;E5RGQ6;A0A0C4DGW2;P57768-2;P57768 E5RG30 SNX16 Sorting nexin-16 1 SS(0.006)S(0.986)FGS(0.008)VSTSSNSSK;SS(0.026)S(0.974)FGSVSTSSNSSK;S(0.001)S(0.066)S(0.923)FGS(0.009)VSTSSNSSK;S(0.001)S(0.135)S(0.863)FGSVSTSSNSSK 275.76 9.0498e-46 30830400.0 11620.7 12522.0 12895.7 14176.199999999999 12591.400000000001 10691.1 11579.500000000002 10397.7 6155.199999999999 9772.8 True False 11891.439700053994 11055.918418680141 11144.534771009638 11700.592790231542 11452.510093192232 10583.557240742122 10706.048992291071 10121.919219510468 10444.924841978916 11027.234075133254 1.0783701170241367 1.0026012274112845 1.0106373633748194 1.0610632467317196 1.0385659735851611 0.9597653562653906 0.9708734683009528 0.9179019099935225 0.9471935365489826 1.0 13.428783349400359 -6.776822796366406 6.498538185147869 0.9543483790606156 1.0361559504134126 0.6614739593039481 0.028179240790109354 0.09580652553444936 15.86333033829651 0.00985630293378983 0.009028640355616822 1.6717726025987355e-07 6.776822796366406 0.08180757135279693 SSS(ph)FGSVSTSSNSSK ddPTM_A459_Selumetinib_30min_R2 2 SSSFGSVSTSSNSSK 15 0 E5RG30;E5RJ65;E5RHF1;E5RGS8;E5RH07;E5RGQ6;A0A0C4DGW2;P57768-2;P57768 E5RG30 SNX16 Sorting nexin-16 1 S(0.001)S(0.064)S(0.935)FGSVSTSSNSSK;S(0.038)S(0.17)S(0.791)FGSVSTSSNSSK 297.45 1.987799999999999e-80 22556000.0 143399.0 136050.0 149685.0 163931.0 152959.0 124183.0 119087.0 116071.0 103453.0 146141.0 True False 135429.45765167926 146484.59753030053 140054.4300647055 141603.31500325163 133742.92294919025 141288.08102896472 124624.78146641383 116408.74739341141 124146.49071833407 141921.52961008175 0.9542559048212139 1.0321520486197933 0.9868441416146939 0.9977578130132588 0.9423723329126907 0.9955366280024083 0.8781245650946028 0.8202331789492073 0.8747544580404171 1.0 17.11473393843439 -7.264690463336748 24.04096629268592 0.878297470520143 0.9857219546579269 0.45015652921409544 0.048438678794262516 129.82969470152835 960048.995528896 0.018873201959656534 0.01332919219995635 5.436376627651613e-08 7.264690463336748 0.10742448413778394 SSS(ph)FHDDHFLSR ddPTM_A459_Selumetinib_30min_R2 3 SSSFHDDHFLSR 12 0 J3QQV3;Q8N8E3 J3QQV3 CEP112 Centrosomal protein of 112 kDa 1 S(0.037)S(0.037)S(0.925)FHDDHFLSR;S(0.003)S(0.099)S(0.897)FHDDHFLSR;S(0.295)S(0.295)S(0.41)FHDDHFLSR 160.46 0.00031288 19617800.0 63715.0 56182.0 78416.0 84559.0 95071.0 64391.0 62456.0 68598.0 61690.0 75790.0 True False 60173.97537135375 60490.97874639731 73370.79993288551 73041.91832758885 83127.33103447637 73260.27576669975 65360.32775421616 68797.60882298982 74029.72376261718 73601.74577393127 0.817561794745724 0.8218688036584914 0.9968622233261272 0.9923938292433724 1.1294206429532674 0.9953605719043629 0.8880268676638632 0.9347279483601187 1.0058147803993733 1.0 16.167452365798084 -5.259866730457396 23.459593406077616 0.9917053786385662 0.8197152567382228 0.5902456975302439 0.05768772348038547 42.88517403247633 639687.2059055995 0.016674506773160135 0.03954025622130361 5.497095342989352e-06 5.259866730457396 -0.17199012190034346 SSS(ph)FSELCHR ddPTM_A459_Selumetinib_30min_R2 1 SSSFSELCHR 10 0 Q5T8I3-2;Q5T8I3 Q5T8I3-2 FAM102B Protein FAM102B 1 S(0.276)S(0.276)S(0.448)FSELCHR 111.5 0.0036762 0.0 8203.6 8209.0 9105.2 10191.0 9764.0 7825.4 7518.6 7207.3 7318.3 8983.3 True False 7747.676753612769 8838.603903904726 8519.381344992194 8802.968219544426 8537.359028732488 8903.277818091547 7868.229797823267 7228.2720497672535 8782.1644903868 8723.928787583542 0.8880949102472916 1.013144893672722 0.9765532883667651 1.009060073034225 0.9786140208851095 1.0205582868538847 0.9019135746524937 0.8285569753910642 1.0066753986903405 1.0 13.090762278136923 -7.2723752231726575 24.602276830069616 0.9199995661479252 0.9834294867510324 0.11228185624056686 0.0588890947645816 942.3256092384177 2119933.5636097356 0.02354447477408677 0.01605081100666582 5.341027041861902e-08 7.2723752231726575 0.06342992060310715 SSS(ph)FSLPSR ddPTM_A459_Selumetinib_30min_R1 1 SSSFSLPSR 9 0 Q14153-2;Q14153 Q14153-2 FAM53B Protein FAM53B 1 S(0.002)S(0.001)S(0.97)FS(0.027)LPSR 132.88 0.003258 13524000.0 3210.8 4040.1 4204.9 4070.0 4306.3 3495.5 3630.3 3460.8 2018.7 2468.0 True False 3285.605392870771 3567.083213808465 3633.897675862371 3359.2509033621395 3916.7959253390145 3460.338443660064 3356.4635482287026 3369.0083417372925 3425.586459985516 2784.7918403557683 1.179838774754174 1.280915565076044 1.3049081885409886 1.2062843817198854 1.406495045187517 1.242584236823242 1.2052834612585983 1.2097882121440318 1.2301050334691743 1.0 11.443353776640286 -9.402320523905523 0.554986150931986 0.9829224696401484 1.2713385200321075 0.6165322485449837 0.060798738907749506 2.2956569828330915 0.9286864410686548 0.15110653601818855 0.027490535790064642 3.959856756628692e-10 9.402320523905523 0.28841605039195906 SSS(ph)FSLPSR ddPTM_A459_Selumetinib_30min_R2 3 SSSFSLPSR 9 0 Q14153-2;Q14153 Q14153-2 FAM53B Protein FAM53B 1 S(0.048)S(0.003)S(0.58)FS(0.369)LPSR;S(0.03)S(0.001)S(0.631)FS(0.338)LPSR;S(0.042)S(0.027)S(0.813)FS(0.118)LPSR 130.98 0.0037126 25978900.0 146146.0 129052.0 154703.0 143789.0 171795.0 120194.0 115713.0 121426.0 103410.0 138074.0 True False 138023.7903887918 138949.8734324169 144749.57740789076 124204.69015013987 150212.57623321374 136749.63248750157 121093.8837809596 121779.32955684359 124094.88951681372 134087.44486066504 1.0293565555836874 1.0362631160344997 1.0795162631244493 0.9262961963307251 1.1202583238818884 1.019854115570648 0.9030963630248342 0.908208294097846 0.9254773229944464 1.0 17.0328146327438 -7.188003827697049 5.646840234041327 0.9267523709370337 1.0371887571762672 0.47069633841828806 0.05240800804990269 0.18186167769214634 10.489560244596793 0.019568618871191882 0.015004055966627301 6.486287167701778e-08 7.188003827697049 0.11043638623923357 SSS(ph)FVLPK ddPTM_A459_Selumetinib_30min_R2 1 SSSFVLPK 8 0 Q8WYP3;Q8WYP3-2 Q8WYP3 RIN2 Ras and Rab interactor 2 1 S(0.001)S(0.005)S(0.994)FVLPK 97.565 0.020166 5476800.0 78540.0 87258.0 81128.0 82084.0 80395.0 84488.0 77038.0 86412.0 78875.0 73125.0 True False 74175.06122053089 93950.4080213082 75908.31280548763 70904.01759720188 70295.06135958097 96125.45509429777 80620.41964790091 86663.44461372322 94652.20395163601 71013.6912484327 1.0445177530771992 1.3229900652908495 1.068925040664788 0.9984555985007575 0.9898804036768389 1.353618624865093 1.1352799471563906 1.2203765652815 1.3328726093184884 1.0 16.115809578701985 -6.751940856386928 24.99836899907168 1.217631246155438 1.09248209622273 0.18827542606242686 0.12699738879837102 353.0488541333263 929158.406107414 0.04247861721960714 0.04193906825442156 1.7703500338377552e-07 6.751940856386928 -0.12514914993270798 SSS(ph)KESLVR ddPTM_A459_Selumetinib_30min_R1 1 SSSKESLVR 9 1 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 SS(0.003)S(0.987)KES(0.01)LVR 119.74 0.032279 39579000.0 4605.7 5431.4 6441.3 6315.9 5901.0 4247.6 5079.6 5864.4 2701.3 4620.1 True False 4713.003848867855 4795.489163010646 5566.606839528239 5212.94662912652 5367.255591906168 4204.873000512225 4696.44168239058 5708.857061744157 4583.908804854055 5213.134838584966 0.9040632929700193 0.9198858866102753 1.0678041163115624 0.9999638970668755 1.0295639299755837 0.8065920277737494 0.900886285854322 1.0950910034956527 0.8792998736434553 1.0 12.347935460621725 SSS(ph)LDALGPTR ddPTM_A459_Selumetinib_30min_R2 2 SSSLDALGPTR 11 0 Q9H425-2;Q9H425-3;Q9H425;E5RI90 Q9H425-2 C1orf198 Uncharacterized protein C1orf198 1 S(0.001)S(0.006)S(0.994)LDALGPTR;S(0.005)S(0.003)S(0.992)LDALGPTR 147.33 0.00066847 14372800.0 61786.0 54632.0 73680.0 69928.0 67414.0 52436.0 56340.0 59549.0 50681.0 65102.0 True False 58352.181468954885 58822.09873043283 68939.50901671835 60403.685767471645 58944.85063119338 59658.5830333846 58959.92163559211 59722.27773113236 60818.61614545636 63222.33610469026 0.9229678158733197 0.9304005886943019 1.0904296371231994 0.95541685880523 0.9323421794092872 0.9436314237834487 0.9325805604202921 0.9446388952195293 0.9619798933836681 1.0 15.948146724256963 -5.976783338762997 24.99960808984225 0.9479148880437107 0.9839700644574844 0.06739463018074432 0.046197422000237236 547.1955318324729 589213.9808683613 0.01328223477013156 0.019699587520881526 1.05491304114239e-06 5.976783338762997 0.03605517641377365 SSS(ph)LDMNR ddPTM_A459_Selumetinib_30min_R1 4 SSSLDMNR 8 0 E9PMG1;H0YDT0;Q96D71-4;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 SS(0.002)S(0.997)LDMNR;SS(0.001)S(0.999)LDMNR;S(0.005)S(0.005)S(0.991)LDMNR;SS(0.004)S(0.996)LDMNR 166.07 0.00025869 254949600.0 20927.7 23130.3 26309.5 27853.300000000003 25928.8 22341.0 23480.6 21678.4 12835.699999999999 18694.4 True False 21415.274691784478 20422.193723015265 22736.81440773885 22989.244026195756 23583.544618101452 22116.26982400501 21709.439437660494 21103.418410632727 21781.24541756383 21094.008338876363 1.0152302183514368 0.9681514008590325 1.0778802227851019 1.0898471099884066 1.1180210152205572 1.0484621731776134 1.0291756355120942 1.0004461016420014 1.0325797291651244 1.0 14.364545645432685 -10.066698430350689 10.43372712425398 1.0000000658289325 1.0432754258614385 0.08314686216415801 0.04190217778895042 0.0 0.0 0.04559122980619875 0.01105749741722151 8.576331702201893e-11 10.066698430350689 0.04327536003250598 SSS(ph)LDMNR ddPTM_A459_Selumetinib_30min_R2 4 SSSLDMNR 8 0 E9PMG1;H0YDT0;Q96D71-4;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 SSS(1)LDMNR;SS(0.005)S(0.995)LDMNR;SSS(1)LDMNR;SS(0.005)S(0.995)LDMNR 162.64 0.00036287 366329000.0 400829.0 356770.0 459135.0 476250.0 488832.0 355567.0 347553.0 405507.0 330982.0 386353.0 True False 378552.5288256195 384133.11180364183 429594.75396839064 411383.92842292634 427420.55394647265 404543.1267341418 363714.9031632045 406686.9582347026 397187.6484097673 375197.98502435227 1.008940729788433 1.0238144316758782 1.144981506072075 1.0964449299913628 1.1391866987737977 1.0782124181927173 0.9693946067956563 1.0839262855004579 1.0586081595933619 1.0 18.51729255441382 -7.0302225705858845 24.901202670569937 1.0333800256152523 1.086137251156602 0.2170008042265381 0.04962491136063792 1153.8137283316655 950655.2354777204 0.020035885365618566 0.015542407695506582 9.32776141970272e-08 7.0302225705858845 0.05275722554134976 SSS(ph)LESLQTAVAEVR ddPTM_A459_Selumetinib_30min_R1 3 SSSLESLQTAVAEVR 15 0 A0A087WZG6;A0A087X1S9;Q8TEW8-5;Q8TEW8-2;Q8TEW8;R4GN62 A0A087WZG6 PARD3B Partitioning defective 3 homolog B 1 S(0.001)S(0.03)S(0.969)LESLQTAVAEVR;S(0.026)S(0.003)S(0.971)LESLQTAVAEVR;S(0.002)S(0.009)S(0.989)LESLQTAVAEVR 227.41 1.0436e-13 13073500.0 4650.7 4999.700000000001 4697.7 4901.700000000001 4744.4 3980.2999999999997 4214.1 4124.3 2290.5699999999997 3852.1 True False 4759.052261313094 4414.332799702532 4059.778142619007 4045.7101113047174 4315.269857691852 3940.261795823246 3896.2270442086237 4014.9101663855527 3886.9299933863485 4346.554557631467 1.094902226168399 1.0155935560390155 0.9340221292037041 0.9307855354539283 0.9928024140673244 0.9065253279531779 0.896394372266148 0.9236994757920087 0.894255425038176 1.0 12.085656537990472 -4.909483378224054 1.6955091237135458 0.9300042868950172 1.1301964435826501 0.6851059280546828 0.03460403767435367 0.4029458305610566 1.4123601216182202 0.009727347905713076 0.12251358344990017 1.2317331270221131e-05 4.909483378224054 0.2001921566876329 SSS(ph)LESLQTAVAEVR ddPTM_A459_Selumetinib_30min_R2 1 SSSLESLQTAVAEVR 15 0 A0A087WZG6;A0A087X1S9;Q8TEW8-5;Q8TEW8-2;Q8TEW8;R4GN62 A0A087WZG6 PARD3B Partitioning defective 3 homolog B 1 SS(0.012)S(0.988)LESLQTAVAEVR 219.85 2.3025000000000003e-09 6820600.0 26675.0 23234.0 29476.0 33342.0 33540.0 26642.0 25082.0 27172.0 23745.0 30909.0 True False 25192.51028848562 25015.973090915148 27579.54625104223 28800.762081841847 29326.40534859563 30311.69366800352 26248.36269904011 27251.066021433242 28494.663490733434 30016.576858773464 0.8392865851097931 0.8334052616530554 0.918810508633368 0.9594952221683383 0.977006988057797 1.009831794298816 0.8744622287390524 0.9078672144944503 0.949297570632369 1.0 14.873471838504676 -5.3668472250450865 3.1425334979268866 0.9498000775597105 0.8343283700641545 0.5954309182998144 0.03810555589911219 0.18820027823457253 3.4935329945130387 0.011136404570697698 0.027566357804537988 4.296875545239519e-06 5.3668472250450865 -0.11547170749555602 SSS(ph)LESLQTAVAEVTLNGDIPFHRPR ddPTM_A459_Selumetinib_30min_R1 4 SSSLESLQTAVAEVTLNGDIPFHRPR 26 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.189)S(0.189)S(0.609)LES(0.01)LQT(0.002)AVAEVTLNGDIPFHRPR;S(0.045)S(0.045)S(0.91)LESLQTAVAEVTLNGDIPFHRPR;S(0.135)S(0.135)S(0.516)LES(0.211)LQT(0.002)AVAEVTLNGDIPFHRPR;S(0.143)S(0.143)S(0.691)LES(0.012)LQT(0.012)AVAEVTLNGDIPFHRPR 161.91 1.6756e-14 77028500.0 3514.73 5168.030000000001 3685.1800000000003 3489.91 3526.21 4267.25 4015.12 3930.17 2653.5299999999997 3625.1000000000004 True False 3596.616370525937 4562.9546450480375 3184.7527972447638 2880.4627322242186 3207.2649281029385 4224.3253393529985 3712.2562658083425 3825.929124608658 4502.846603836807 4090.41689646422 0.8792786802819226 1.1155231265038734 0.7785888035025678 0.7041978373192491 0.78409243098798 1.032737113667932 0.9075496116342661 0.9353396539887691 1.1008282817648962 1.0 11.99803217521548 -6.767751903433403 24.99968078611829 0.9857658333834917 0.8546306868084407 0.28596624222000966 0.11241411578114209 248.27130524252155 983230.1198792714 0.04301377235690567 0.03885088208799261 1.7070572899607947e-07 6.767751903433403 -0.131135146575051 SSS(ph)LESLQTAVAEVTLNGDIPFHRPRPR ddPTM_A459_Selumetinib_30min_R1 2 SSSLESLQTAVAEVTLNGDIPFHRPRPR 28 2 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 S(0.069)S(0.16)S(0.686)LES(0.08)LQT(0.004)AVAEVTLNGDIPFHRPRPR;S(0.141)S(0.141)S(0.582)LES(0.135)LQTAVAEVTLNGDIPFHRPRPR 98.225 3.7536e-07 15548000.0 1239.5500000000002 1180.38 1675.62 1567.4499999999998 1707.1399999999999 919.3699999999999 1054.65 1112.57 809.99 584.23 True False 1268.4291032555634 1042.1805608562258 1448.0800075218215 1293.7242821805853 1552.729488420046 910.1219725211712 975.0969013964141 1083.0610294633204 1374.4938706710598 659.2216113821111 1.9241315535699746 1.5809259630781984 2.1966512968010945 1.9625028364409784 2.355398338905522 1.3806009342033363 1.4791640391643792 1.6429392039993895 2.0850255011957555 1.0 9.36461972920533 -6.777955791265054 24.999715706478213 1.555330754940846 1.98882841994919 0.37262130590287756 0.3133374281801123 305.0227361753268 461688.23055649677 0.11031314557020745 0.09755596619495999 1.6674169375758592e-07 6.777955791265054 0.43349766500834397 SSS(ph)LGNLK ddPTM_A459_Selumetinib_30min_R1 1 SSSLGNLK 8 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6;H0YGH8 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.022)S(0.022)S(0.956)LGNLK 118.03 0.0085674 14366000.0 6059.9 8563.5 5568.4 6293.0 5572.8 6509.5 7150.6 5771.0 3508.8 5747.1 True False 6201.083879487223 7560.881438936856 4812.241865031758 5194.045684240282 5068.741223957752 6444.02034015311 6611.224485018912 5617.934333150112 5954.177327387518 6484.796266494589 0.9562496067188355 1.1659397039197894 0.7420806556245221 0.8009574195995469 0.7816346135878995 0.9937120728754181 1.0194960972293836 0.866323952562188 0.9181749252711833 1.0 12.662845534553863 -9.443833249605344 15.76726269815542 1.0000171645025553 0.914819166398972 0.041847290157931316 0.12035930336446725 0.0 0.0 0.12364951176537638 0.029989411621452976 3.5988748994255186e-10 9.443833249605344 -0.0851979981035833 SSS(ph)LGNLK ddPTM_A459_Selumetinib_30min_R2 2 SSSLGNLK 8 0 Q86W92-2;Q86W92-4;Q86W92;Q86W92-3;F5GZP6;H0YGH8 Q86W92-2 PPFIBP1 Liprin-beta-1 1 S(0.024)S(0.024)S(0.953)LGNLK;S(0.033)S(0.196)S(0.77)LGNLK 126.39 0.0048488 52469000.0 492440.0 417550.0 447320.0 507910.0 460010.0 470190.0 471090.0 484870.0 422820.0 452280.0 True False 465072.1561935089 449574.7423651391 418539.918205191 438731.7818063804 402219.4312584223 534954.4045401468 492996.61844712566 486280.89142545016 507395.8145778866 439221.5012354359 1.0588556226991634 1.0235717994237117 0.9529130906112928 0.9988850285614934 0.9157553310278875 1.2179604209617125 1.1224327977123887 1.1071427288000388 1.1552162477262407 1.0 18.74458915484201 -6.757350835892289 24.999931394507183 1.127364506155069 0.9902951449872276 0.5241476722957248 0.06202709968067804 80.32308655965346 491145.8127711145 0.020293905037835045 0.019595987605075124 1.748433681667872e-07 6.757350835892289 -0.1370693611678414 SSS(ph)LIQLTSQNSSPNQQR ddPTM_A459_Selumetinib_30min_R1 2 SSSLIQLTSQNSSPNQQR 18 0 H7C419;O95639 H7C419 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 S(0.031)S(0.031)S(0.938)LIQLTSQNSSPNQQR;S(0.026)S(0.026)S(0.947)LIQLT(0.001)SQNSSPNQQR 201.75 1.2688e-10 8425300.0 1740.89 1873.01 2142.23 2392.6000000000004 2600.1000000000004 1741.96 2076.33 2204.1 1216.3400000000001 1562.87 True False 1781.449349817739 1653.7171184612744 1851.3269324270852 1974.7773246644354 2364.9214140849385 1724.4374639731316 1919.7107564371258 2145.6401080741916 2064.040142041305 1763.4795881429568 1.0101899459430121 0.9377580152219008 1.0498147780528817 1.1198186460122213 1.3410540331659488 0.9778607450676882 1.088592558340122 1.2167082185134173 1.170436083252234 1.0 10.784209161670733 -5.594586417661272 3.105552042187402 1.140399673628308 0.9758256833418021 0.2840738752992531 0.09949303715885964 0.2994446738457272 5.795854781066266 0.028159641940112976 0.05569220093893273 2.5433936480850602e-06 5.594586417661272 -0.16457399028650588 SSS(ph)LIQLTSQNSSPNQQR ddPTM_A459_Selumetinib_30min_R2 4 SSSLIQLTSQNSSPNQQR 18 0 H7C419;O95639 H7C419 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 SSS(0.999)LIQLTSQNSSPNQQR;SS(0.003)S(0.997)LIQLTSQNSSPNQQR;S(0.01)S(0.01)S(0.979)LIQLTSQNSSPNQQR;SS(0.076)S(0.924)LIQLTSQNSSPNQQR 286.57 2.0485999999999997e-68 28893900.0 69978.3 57529.3 84193.0 88986.0 93729.0 51191.6 52688.6 69992.4 51606.3 66460.0 True False 66089.18623133012 61941.612324145 78776.1140424073 76865.95329058767 81953.92507210853 58242.77822892312 55138.72430048023 70196.06629613436 61929.00200049848 64541.127116182484 1.0239856225683963 0.9597231268155881 1.2205568381320637 1.1909608140592103 1.2697938312199093 0.9024134041551287 0.8543192033387224 1.087617608068298 0.9595277425046849 1.0 15.977931152148527 -6.77925935919238 24.997244250390615 0.9595981522167775 1.1314612260439132 0.4161019533076352 0.10199717879095405 274.1606518061947 384580.38246265164 0.03925958201349146 0.034694254723065567 1.662419562538019e-07 6.77925935919238 0.17186307382713573 SSS(ph)LPAYGR ddPTM_A459_Selumetinib_30min_R1 3 SSSLPAYGR 9 0 Q08495;Q08495-2;Q08495-3;Q08495-4 Q08495 DMTN Dematin 1 S(0.002)S(0.002)S(0.997)LPAYGR;SS(0.005)S(0.995)LPAYGR;SS(0.002)S(0.998)LPAYGR 142.98 0.00056485 94329000.0 9308.3 10123.5 10662.0 10765.599999999999 10147.3 8754.7 9842.8 8270.2 5262.85 7722.5 True False 9525.165279201126 8938.235913712539 9214.158962173802 8885.590055340406 9229.478506651323 8666.635666631602 9100.349671516251 8050.847430604415 8930.672066644262 8713.75809852003 1.093117937347711 1.025761309030444 1.057426526878083 1.019719615219702 1.0591846138371555 0.9945921803938498 1.0443656535590404 0.9239236778872477 1.0248932740238765 1.0 13.08907934800587 -6.957836658037529 0.9913655002575551 0.9856146543872644 1.0525099562590663 0.35222976712294785 0.03510508954438184 0.5689512429737742 1.1658897357289713 0.02100245114624413 0.015743096468251356 1.1019536860542962e-07 6.957836658037529 0.06689530187180193 SSS(ph)LPAYGR ddPTM_A459_Selumetinib_30min_R2 4 SSSLPAYGR 9 0 Q08495;Q08495-2;Q08495-3;Q08495-4 Q08495 DMTN Dematin 1 SS(0.004)S(0.996)LPAYGR;SS(0.001)S(0.999)LPAYGR;S(0.021)S(0.002)S(0.977)LPAYGR;S(0.001)S(0.012)S(0.987)LPAYGR 169.76 0.00067933 99722000.0 322389.0 286134.0 307894.0 365731.0 315321.0 261677.0 246750.0 276451.0 217773.0 295449.0 True False 304471.91000542033 308079.5577341784 288084.4352496401 315917.80687883426 275707.55697449396 297720.6314827028 258224.36392584917 277255.426641073 261333.68508601806 286918.61970130954 1.061178637769777 1.073752404270235 1.0040632272298822 1.1010711232603645 0.9609259840351713 1.037648347091027 0.8999916568491376 0.9663207878586054 0.9108286013576737 1.0 18.13028206986683 -6.719900923447362 1.2506078780289605 0.9441128849736827 1.0568187203977377 0.5151910777032801 0.044812073334262174 0.3343683617859518 1.1016872709311067 0.0202677103652817 0.01899547339412429 1.905895464483787e-07 6.719900923447362 0.11270583542405499 SSS(ph)LSDLTHR ddPTM_A459_Selumetinib_30min_R2 1 SSSLSDLTHR 10 0 Q5T9C2-3;Q5T9C2-2;Q5T9C2 Q5T9C2-3 FAM102A Protein FAM102A 1 S(0.294)S(0.294)S(0.413)LSDLTHR 114.72 0.0031853000000000003 0.0 14062.0 11328.0 14252.0 17866.0 18026.0 12198.0 9296.1 11386.0 11087.0 15499.0 True False 13280.490334646098 12196.821174739029 13335.041836404325 15432.619979430945 15761.412725515354 13878.163777580769 9728.387069872688 11419.131374946233 13304.709796662948 15051.50359876185 0.8823364554580821 0.8103390531522944 0.8859607778654937 1.025320817828489 1.0471653295031536 0.9220450094249985 0.6463398826594942 0.7586704743495248 0.8839455612765096 1.0 13.877619994516067 -7.043569143695988 24.809188320479763 0.7995658812040684 0.9322099830252569 0.1816599944069025 0.10668066733895748 630.457321430304 358993.73498369264 0.042605912879536065 0.033004835320619534 9.04546414123033e-08 7.043569143695988 0.13264410182118858 SSS(ph)LVDIR ddPTM_A459_Selumetinib_30min_R1 1 SSSLVDIR 8 0 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 S(0.349)S(0.06)S(0.591)LVDIR 93.556 0.023898 1783800.0 3349.9 3602.8 2796.9 2892.5 3219.4 2724.9 3604.6 3495.7 1893.6 3052.5 True False 3427.9461522292845 3180.982501103721 2417.0963422719847 2387.37917394963 2928.2058384312336 2697.4899800112466 3332.7021199198894 3402.982680366113 3213.3008969280104 3444.318108867902 0.9952466769557476 0.9235449225534119 0.701763387083445 0.6931355056325873 0.8501554577354915 0.78317097746174 0.9675941694640106 0.9879989515499846 0.9329280267855911 1.0 11.750002677365634 -7.271203871315166 23.250084687774034 0.9711302393047713 0.8186204584663682 0.4052634109726828 0.08743515758738943 300.8605939644612 716368.9832305185 0.03984053717354071 0.027291160267008105 5.35545196951497e-08 7.271203871315166 -0.15250978083840305 SSS(ph)LVDIR ddPTM_A459_Selumetinib_30min_R2 2 SSSLVDIR 8 0 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 S(0.06)S(0.207)S(0.733)LVDIR;S(0.015)S(0.06)S(0.925)LVDIR 128.91 0.0042103 7844700.0 88107.0 55794.0 77918.0 85203.0 88983.0 78389.0 89085.0 103484.0 89284.0 60784.0 True False 83210.36566026618 60073.22039401393 72904.84071070392 73598.20441662702 77804.16002188686 89186.37320550752 93227.62901857858 103785.1213073016 107143.29480339603 59029.00798420159 1.4096521100699582 1.017689818031362 1.2350680318093104 1.2468141839064057 1.318066535062053 1.5108905985575294 1.5793527996189576 1.758205412076016 1.8150956362348432 1.0 15.849136476234156 -6.721314270042507 1.8227929047916993 1.6013020948535999 1.2099942584092451 0.27840821117676917 0.2259520568904823 0.3655839123940248 2.507613357662916 0.08822216273567786 0.08309876383541942 1.8997030935906805e-07 6.721314270042507 -0.39130783644435474 SSS(ph)LVDIREEETEGGSR ddPTM_A459_Selumetinib_30min_R1 1 SSSLVDIREEETEGGSR 17 1 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 S(0.143)S(0.143)S(0.711)LVDIREEET(0.002)EGGSR 122.96 0.0050627 0.0 1192.9 1159.5 1350.2 1239.1 1134.9 985.84 970.37 1161.0 523.8 895.14 True False 1220.6922490206616 1023.7452009630747 1166.850256117714 1022.714445787721 1032.2484953828691 975.9233446711015 897.1742096506313 1130.2065085405093 888.8503431616451 1010.0399384019703 1.2085583971580112 1.0135690303323928 1.1552516012028597 1.0125485210077967 1.0219878008151202 0.9662225299874319 0.8882561723946194 1.1189720976070114 0.8800150463039464 1.0 9.980196624961218 -5.980376739330676 1.415336334589612 0.974750309452424 1.1221599345016162 0.4027031978658008 0.07864875210621894 0.4431900826033533 1.8004114544768874 0.02632736818407158 0.04811932808513201 1.0462205847511447e-06 5.980376739330676 0.1474096250491922 SSS(ph)LVDIREEETEGGSR ddPTM_A459_Selumetinib_30min_R2 1 SSSLVDIREEETEGGSR 17 1 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 S(0.237)S(0.237)S(0.526)LVDIREEETEGGSR 119.51 0.0065316 0.0 8556.4 8659.5 9786.3 9744.8 14212.0 7568.5 7638.0 7925.0 6234.6 9548.2 True False 8080.869541983061 9323.65580531891 9156.660112517802 8417.541429282368 12426.561503107967 8610.99217499755 7993.18213440987 7948.060437945628 7481.694209278863 9272.518656797074 0.8714859296680418 1.0055149146002904 0.987505170000996 0.90779449908273 1.340149528197376 0.9286573037720876 0.8620292317827362 0.8571630569995594 0.8068675282518332 1.0 13.17874555017188 -6.990314304956859 24.996065676366786 0.873287730481765 1.0253485515007057 0.2192530475435941 0.1262030953035657 303.81524574713364 784058.0700062494 0.0449450652507914 0.03959210280730795 1.0225526888262227e-07 6.990314304956859 0.1520608210189407 SSS(ph)MAAGLER ddPTM_A459_Selumetinib_30min_R1 4 SSSMAAGLER 10 0 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6;I3L0Y9 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 SS(0.012)S(0.987)MAAGLER;SS(0.007)S(0.993)MAAGLER;S(0.004)S(0.144)S(0.851)MAAGLER;SS(0.006)S(0.994)MAAGLER 166.29 0.00033071 311468000.0 14629.900000000001 16144.5 14944.400000000001 16339.5 18529.8 13749.5 17620.9 14438.0 7643.200000000001 10120.400000000001 True False 14970.748205170083 14254.294434625572 12915.032563713212 13486.113055401886 16853.78286170189 13611.192513547148 16291.741326332018 14055.057338766477 12969.952162758862 11419.451921043974 1.3109865787500463 1.2482468101956363 1.1309678129046767 1.1809772613122904 1.4758836919873037 1.1919304540758384 1.4266657838726304 1.2307996422197427 1.1357771154373528 1.0 13.479205789465027 -10.474497768388948 7.678222963545723 0.9999999976714727 1.2612404973186668 0.3330184697948325 0.10998430900681384 4.413901520676696e-09 4.152667204911232e-10 0.1069886567904233 0.025948560553131196 3.3535302764906104e-11 10.474497768388948 0.2612404996471941 SSS(ph)MAAGLER ddPTM_A459_Selumetinib_30min_R2 3 SSSMAAGLER 10 0 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6;I3L0Y9 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 S(0.128)S(0.128)S(0.743)MAAGLER;S(0.004)S(0.013)S(0.983)MAAGLER;SS(0.005)S(0.995)MAAGLER 158.08 0.00048138 110179000.0 351481.0 462908.0 417441.0 772989.0 691143.0 551402.0 333124.0 329986.0 459949.0 550328.0 True False 331947.0931099236 498411.5551161812 390583.3005353954 667706.5647195999 604315.4374431857 627352.6203710112 348614.9260726834 330946.204627877 551951.6520488252 534438.6007161373 0.6211136184121449 0.9325889904814499 0.730829135492873 1.2493606633669163 1.1307481095740741 1.1738534969786443 0.6523011728672783 0.6192408336231991 1.0327690614211262 1.0 19.027664687058994 SSS(ph)MAAGLERNGRMR ddPTM_A459_Selumetinib_30min_R2 1 SSSMAAGLERNGRMR 15 2 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 S(0.003)S(0.149)S(0.848)MAAGLERNGRMR 74.649 0.042534 0.0 2956.6 2573.3 2697.8 3440.9 3457.3 1141.2 2577.3 1296.0 1997.8 2028.4 True False 2792.2840082075563 2770.6638355363666 2524.2264851425493 2972.2434841164204 3022.963065345847 1298.3899412178382 2697.1495568230644 1299.7711454356497 2397.4158231959245 1969.834821583879 1.4175219046855783 1.406546277473442 1.2814406860332088 1.508879552513209 1.5346276917346717 0.6591364549916149 1.3692262555569892 0.6598376326754883 1.217064393890774 1.0 10.943858943748406 -6.7429130621740825 24.99997785833392 0.984053559220503 1.4246620050678211 0.525912960154953 0.2129953997143094 188.16586610148215 253916.2936301032 0.065155546106913 0.0650437917460935 1.8075359254871407e-07 6.7429130621740825 0.4406084458473182 SSS(ph)MEIR ddPTM_A459_Selumetinib_30min_R1 1 SSSMEIR 7 0 E9PK89;Q8TBN0;Q8TBN0-2 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 S(0.001)S(0.013)S(0.987)MEIR 112.11 0.014704 7114400.0 5408.8 7303.2 6463.5 7953.5 6998.5 6100.9 7554.4 6489.7 3445.7 5734.3 True False 5534.814516307279 6448.137948834433 5585.792201464116 6564.570530685692 6365.486910685529 6039.530485173987 6984.565525917664 6317.572074483503 5847.101236029176 6470.353261812026 0.8554114887317993 0.9965665996772219 0.863290144362197 1.0145613794272617 0.9837927935487824 0.9334158802146473 1.0794720540438671 0.9763875044921833 0.9036757344515827 1.0 12.659628765836816 -5.772388106052319 24.9974784153206 0.9852910117476351 0.914237122031414 0.28718863947320017 0.05675472015146959 288.56291201871346 658830.0413546999 0.01562735519157527 0.023430751254397385 1.688930948616616e-06 5.772388106052319 -0.07105388971622106 SSS(ph)MEIR ddPTM_A459_Selumetinib_30min_R2 2 SSSMEIR 7 0 E9PK89;Q8TBN0;Q8TBN0-2 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 S(0.012)S(0.013)S(0.975)MEIR;S(0.003)S(0.042)S(0.954)MEIR 106.68 0.017016999999999997 21113600.0 122509.0 116732.0 140608.0 147277.0 144515.0 98421.0 123110.0 123759.0 103670.0 132412.0 True False 115700.44022238368 125684.96904746084 131561.4343624149 127217.6185330041 126359.73371950786 111977.59937311661 128834.85893783705 124119.1182005946 124406.89678182096 128588.92151230776 0.8997698935620168 0.9774167756390353 1.023116399260123 0.9893357610968655 0.982664231361591 0.8708184037642682 1.0019125864237515 0.9652395925003124 0.9674775658641284 1.0 16.972406828084544 -9.361165223933362 1.1540349087416226 1.0000974568628482 0.9655798197435822 0.056979533421326556 0.04351296822350622 24.31355965220104 30.03576938657333 0.04911190738109706 0.013091323670015214 4.353462181182193e-10 9.361165223933362 -0.03451763711926603 SSS(ph)MELHR ddPTM_A459_Selumetinib_30min_R2 1 SSSMELHR 8 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.302)S(0.302)S(0.396)MELHR 76.465 0.036872 8816500.0 124220.0 103410.0 116740.0 127560.0 136740.0 136590.0 144830.0 196780.0 114840.0 143670.0 True False 117316.34969205922 111341.21448444233 109229.07549690138 110186.10794672616 119561.49872888994 155404.03265943244 151564.88197520058 197352.59722131718 137811.20889769756 139521.87380051086 0.840845571353197 0.7980197760505898 0.7828813685019577 0.7897407406115464 0.8569373064745363 1.1138327520000912 1.086316273188166 1.4144921641712827 0.9877390916835075 1.0 17.090131795413654 -6.748616543402213 2.914847799441884 1.1525514919198527 0.8012849891817487 0.6504522566251876 0.11209427111896263 0.14733344164224976 2.5733463129459415 0.03969836256396721 0.03716974065158633 1.7839531984970454e-07 6.748616543402213 -0.351266502738104 SSS(ph)MSSIDLVSASDDVHR ddPTM_A459_Selumetinib_30min_R1 2 SSSMSSIDLVSASDDVHR 18 0 A0A2U3TZL3;Q9Y5P4;Q9Y5P4-3;A0A0A0MRE4;A0A2R8YFA1 A0A2U3TZL3 COL4A3BP Collagen type IV alpha-3-binding protein 1 SS(0.021)S(0.973)MS(0.006)SIDLVSASDDVHR;S(0.116)S(0.116)S(0.69)MS(0.072)S(0.006)IDLVSASDDVHR 272.32 3.6064999999999994e-54 15344100.0 3852.3 3576.1000000000004 4065.4 3332.2 3899.1000000000004 3264.0 3198.6000000000004 3442.4 1634.55 2607.3999999999996 True False 3942.0510947290595 3157.4085495162153 3513.341009643723 2750.2938231408643 3546.4270934420188 3231.16712347488 2957.3270267923667 3351.096369508917 2773.7119671914247 2942.0851882267534 1.3398833964780617 1.0731873305882218 1.1941669886728452 0.9348110769010448 1.2054127826188177 1.0982574999544326 1.0051806244858599 1.1390208491986875 0.9427707866145065 1.0 11.522623305168143 -2.0904753822825417 1.1801539038643183 1.0650302826375724 199.9999999895639 0.4434713152934816 0.0914625823861281 1007.7656080228841 2.5663427518614434 0.025689201903350313 541340.5379494579 0.00811941272026373 2.0904753822825417 198.93496970692632 SSS(ph)MSSIDLVSASDDVHR ddPTM_A459_Selumetinib_30min_R2 3 SSSMSSIDLVSASDDVHR 18 0 A0A2U3TZL3;Q9Y5P4;Q9Y5P4-3;A0A0A0MRE4;A0A2R8YFA1 A0A2U3TZL3 COL4A3BP Collagen type IV alpha-3-binding protein 1 S(0.133)S(0.133)S(0.713)MS(0.021)SIDLVSASDDVHR;S(0.111)S(0.111)S(0.769)MS(0.009)SIDLVSASDDVHR;S(0.074)S(0.074)S(0.332)MS(0.26)S(0.26)IDLVSASDDVHR 163.96 2.4125e-06 14968400.0 47109.0 34111.9 48321.0 54671.0 64398.0 52345.0 33199.5 40080.0 40559.0 54766.0 True False 44490.870372268735 36728.173042953786 45212.07946792684 47224.71548726459 56307.74751457547 59555.04860940035 34743.34253356124 40196.62616439883 48671.93331314623 53184.763280843385 0.8365341430088474 0.6905769768873429 0.8500945887299224 0.8879369310697761 1.0587195286973659 1.1197765099549004 0.6532574442439126 0.7557921420490228 0.9151480670532076 1.0 15.698725371749017 -5.514366318938651 3.9058164467311816 0.905581334532986 0.7628474531909105 0.16534227868486895 0.13256050291378407 0.43286814796314155 14.795099965278906 0.03975675404421482 0.08077777053251618 3.0593818160838368e-06 5.514366318938651 -0.14273388134207543 SSS(ph)MSSLTGAYASGIPSSSR ddPTM_A459_Selumetinib_30min_R1 2 SSSMSSLTGAYASGIPSSSR 20 0 Q96HA1;Q96HA1-2;Q96HA1-3 Q96HA1 POM121 Nuclear envelope pore membrane protein POM 121 1 S(0.107)S(0.107)S(0.785)MSSLTGAYASGIPSSSR;SSS(1)MSSLTGAYASGIPSSSR 239.7 1.4776999999999997e-67 8004700.0 1179.92 1626.58 1426.0800000000002 2031.0 1472.56 1687.05 1552.1 1335.32 694.17 1151.07 True False 1207.4098402753452 1436.1392574234737 1232.4261688967188 1676.3239765917701 1339.367208001584 1670.0798087188407 1435.0238473971212 1299.9029758693487 1177.9557898291696 1298.821046871279 0.9296198603986796 1.1057252736110026 0.9488806574743316 1.2906504561424035 1.0312176656114223 1.285842890167113 1.1048664870760605 1.0008330085200545 0.9069423325613172 1.0 10.342986952879476 -7.871181039262352 3.903143497622535 0.9539229588931032 1.1058814342702736 0.21689713558903534 0.11504397130972555 0.33129051850492747 9.254313820546539 0.06829065911287131 0.030557321793342127 1.3452994379070522e-08 7.871181039262352 0.15195847537717044 SSS(ph)MSSLTGAYASGIPSSSR ddPTM_A459_Selumetinib_30min_R2 2 SSSMSSLTGAYASGIPSSSR 20 0 Q96HA1;Q96HA1-2;Q96HA1-3 Q96HA1 POM121 Nuclear envelope pore membrane protein POM 121 1 SS(0.007)S(0.99)MS(0.003)SLTGAYASGIPSSSR;S(0.006)S(0.129)S(0.861)MS(0.002)S(0.001)LTGAYASGIPSSSR 298.33 2.0365999999999996e-100 9104000.0 33583.0 29488.0 32475.0 31750.0 28759.0 22243.3 34857.0 29949.0 25561.7 27622.0 True False 31716.591303400648 31749.634781135665 30385.593856106552 27425.595228195034 25146.03731127793 25307.1126704265 36477.91956783516 30036.146631676147 30674.754253572588 26824.481089425102 1.1823748313216818 1.1836066716553255 1.1327560728876627 1.0224091618684437 0.9374286580772346 0.9434334474564435 1.3598741927654918 1.1197288973286856 1.1435357929688101 1.0 14.711262642350295 -14.211420023487412 0.007662656988025273 3.5893422577955325e-07 2.0741355747462635 0.03895829679932905 0.1206907838767714 131647.46950898142 80.1620249892918 12112.144120914712 9708.644668912466 6.145821982724395e-15 14.211420023487412 2.0741352158120376 SSS(ph)MSSLTGAYTSGIPSSSR ddPTM_A459_Selumetinib_30min_R2 1 SSSMSSLTGAYTSGIPSSSR 20 0 A8CG34-2;A8CG34 A8CG34-2 POM121C Nuclear envelope pore membrane protein POM 121C 1 S(0.002)S(0.002)S(0.974)MS(0.015)S(0.002)LT(0.005)GAYTSGIPSSSR 130.95 0.00016144 5581600.0 26875.0 22360.0 25783.0 28085.0 23251.0 17467.0 28467.0 24740.0 20837.0 23216.0 True False 25381.39508914903 24074.940101268076 24124.149850407863 24259.774550672686 20330.0015134227 19872.920700360984 29790.77190629038 24811.98930407252 25004.98223442462 22545.693757587913 1.125775740682486 1.067828755243581 1.070011422571049 1.0760269704500838 0.9017243706053841 0.8814508399712745 1.3213508631227675 1.1005201068927795 1.1090801863663662 1.0 14.460564283635877 -7.249401783785632 24.99409756410389 1.1411144779452673 1.0220020944039807 0.21810646378595122 0.103627504238614 1183.2221446646013 2456769.5293815285 0.041341187116589156 0.03178188787702543 5.6311645245166015e-08 7.249401783785632 -0.11911238354128661 SSS(ph)MSYVDGFIGTWPK ddPTM_A459_Selumetinib_30min_R1 1 SSSMSYVDGFIGTWPK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.092)S(0.14)S(0.708)MS(0.06)YVDGFIGTWPK 197.47 1.0581e-06 62777000.0 3971.7 4756.4 4783.5 5165.8 4565.6 4225.4 3997.1 4764.0 2316.7 3441.5 True False 4064.232882417102 4199.518476809628 4133.926973884675 4263.690004075711 4152.642286122146 4182.896312356236 3695.595528916326 4637.643244347102 3931.2706949266567 3883.2500480487765 1.046606021278301 1.0814442605671934 1.0645533825363258 1.097969471787709 1.069372879608598 1.0771637830682634 0.9516759114631979 1.1942685088428409 1.0123660970279287 1.0 11.923048892105573 SSS(ph)MSYVDGFIGTWPK ddPTM_A459_Selumetinib_30min_R2 3 SSSMSYVDGFIGTWPK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.002)S(0.007)S(0.991)MS(0.001)YVDGFIGTWPK;S(0.083)S(0.083)S(0.641)MS(0.193)YVDGFIGTWPK;S(0.074)S(0.074)S(0.506)MS(0.345)YVDGFIGTWPK 287.43 1.8215999999999997e-74 50644900.0 164487.0 138671.0 159396.0 172311.0 210972.0 128065.0 131710.0 158950.0 137670.0 128980.0 True False 155345.4710336318 149306.6198024574 149140.63489724274 148841.94454694557 184467.81124638973 145704.79129167763 137834.7759784138 159412.51818441105 165207.84682119504 125256.01226971416 1.240223668458532 1.192011601654338 1.190686436480971 1.1883017976529842 1.472726202149679 1.1632558681329488 1.1004244305783402 1.2726935441721359 1.3189614121312794 1.0 16.934520328663886 -10.036965238332684 5.874821374524313 1.000000000457591 1.235233963592915 0.35020348815839686 0.09708280267702057 16923428.81428162 9637732.088047156 0.1231352708540467 0.0242100457418577 9.184061043247933e-11 10.036965238332684 0.23523396313532396 SSS(ph)NVNGGPELDR ddPTM_A459_Selumetinib_30min_R1 2 SSSNVNGGPELDR 13 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 S(0.009)S(0.009)S(0.983)NVNGGPELDR;S(0.075)S(0.075)S(0.851)NVNGGPELDR 218.12 1.6942e-08 23345000.0 3386.7 3737.2 4264.5 3846.7000000000003 4002.8 3686.6000000000004 3865.8 3486.7 2123.77 3006.8 True False 3465.6035206289494 3299.646886622855 3685.404323221738 3174.9460565019995 3640.7474467517404 3649.516151164982 3574.1995936265666 3394.2213896022363 3603.882575976341 3392.752068712208 1.0214726718726588 0.9725576227782855 1.0862580726744977 0.9358025556247376 1.0730956382950978 1.0756801785844123 1.05348092676375 1.0004330764112057 1.0622298661936331 1.0 11.728240291101061 SSS(ph)NVNGGPELDR ddPTM_A459_Selumetinib_30min_R2 2 SSSNVNGGPELDR 13 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 SSS(1)NVNGGPELDR;S(0.094)S(0.094)S(0.813)NVNGGPELDR 175.27 0.00010173 15731200.0 34876.0 34662.0 39828.0 44464.0 39615.0 38528.0 36302.0 33714.0 39680.0 33935.0 True False 32937.73153968974 37320.463944103496 37265.509841447645 38407.926495321735 34638.20953740656 43834.8822776383 37990.11493104836 33812.10215834686 47617.1087518342 32955.20837628126 0.999469679074944 1.13246026297209 1.1307927237464723 1.1654584627953661 1.0510693527380819 1.3301351876502603 1.1527802979510473 1.026001771018457 1.4449038891863144 1.0 15.00821887224321 -3.516315849995743 0.7920755157882993 1.1732009652589201 2.9917564219807694e-09 0.12579252205748404 0.1289522983427277 33.679390740321445 3.415052037440857 0.04436555604497973 54.95581894314173 0.0003045679148348728 3.516315849995743 -1.1732009622671637 SSS(ph)PAELDLKDDLQQTQGK ddPTM_A459_Selumetinib_30min_R1 1 SSSPAELDLKDDLQQTQGK 19 1 H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 H7C1F9 RALGAPA2 Ral GTPase-activating protein subunit alpha-2 1 S(0.103)S(0.135)S(0.763)PAELDLKDDLQQTQGK 123.58 0.0002265 9905800.0 2638.4 3189.8 3146.1 3568.6 2783.4 2670.9 3229.6 3151.0 1563.5 2972.3 True False 2699.8695865672844 2816.336733102211 2718.876900290284 2945.411000918459 2531.641961449184 2644.0331709831685 2985.9886718341236 3067.4252441095136 2653.145306478109 3353.823657653749 0.805012386505749 0.8397390622118903 0.8106797428319003 0.8782247671837926 0.754852437059931 0.7883638022974852 0.8903236951709759 0.9146054048218527 0.7910807416553866 1.0 11.711591119385263 -14.522878300538444 0.21477668489207918 1.8355685791696827 0.8096341966146194 0.538319567388192 0.04757351417942277 120.01124419569203 1.1957150062880741 43.18894657306493 0.09885215122922979 3.000003072169734e-15 14.522878300538444 -1.0259343825550633 SSS(ph)PAELDLKDDLQQTQGK ddPTM_A459_Selumetinib_30min_R2 1 SSSPAELDLKDDLQQTQGK 19 1 H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 H7C1F9 RALGAPA2 Ral GTPase-activating protein subunit alpha-2 1 S(0.13)S(0.13)S(0.739)PAELDLKDDLQQTQGK 123.58 0.0002265 11583000.0 39817.0 25623.0 34581.0 32154.0 29815.0 25180.0 30030.0 26764.0 18461.0 26736.0 True False 37604.1305400799 27588.201709069417 32356.09610894599 27774.56973125618 26069.373150518146 28648.316438718135 31426.454503316127 26841.878808981284 22153.715843437774 25964.062211529563 1.4483146063092343 1.0625533664304132 1.246187743864594 1.06973128877047 1.0040560270627383 1.1033834461387404 1.2103828071002287 1.0338089082632809 0.8532453690393728 1.0 14.66422849763032 -1.5228787452803376 0.7645322911497012 1.0505094483447737 70.48044247739621 0.5342673394230215 0.10607203003161465 352.456736766687 1.4310331227698039 0.03988514585399733 42220.92767144749 0.029999999999999995 1.5228787452803376 69.42993302905144 SSS(ph)PAGETEGDREPQAR ddPTM_A459_Selumetinib_30min_R1 3 SSSPAGETEGDREPQAR 17 1 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(0.037)S(0.037)S(0.923)PAGET(0.003)EGDREPQAR;SSS(1)PAGETEGDREPQAR;S(0.012)S(0.012)S(0.977)PAGETEGDREPQAR 275.83 8.309899999999998e-52 107379000.0 3983.5200000000004 6991.200000000001 3550.33 3781.68 4293.75 4342.719999999999 5729.98 4801.75 2599.0 5125.86 True False 4076.3282654193886 6172.667053879295 3068.214686566733 3121.280578925437 3905.3810706231334 4299.036179674274 5297.762995366633 4674.3919917178255 4410.31317655043 5783.8140611045455 0.7047820386952282 1.0672312402623279 0.5304829398303289 0.5396578358069416 0.6752259027285044 0.7432874110848022 0.9159635734131656 0.8081850388574124 0.7625267911375742 1.0 12.497805457726662 -7.096074939656114 5.233975311289335 0.8548047494094334 0.7052494761185002 0.21750519828282722 0.15017589299062656 0.4378452086611114 18.638078287312354 0.061804652300772 0.047877504701216204 8.015397418159054e-08 7.096074939656114 -0.1495552732909332 SSS(ph)PAGETEGDREPQAR ddPTM_A459_Selumetinib_30min_R2 2 SSSPAGETEGDREPQAR 17 1 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(0.129)S(0.129)S(0.738)PAGET(0.003)EGDREPQAR;S(0.011)S(0.011)S(0.945)PAGET(0.033)EGDREPQAR 96.391 0.0033060000000000003 99148200.0 31548.0 26998.0 35090.0 32128.0 35124.0 25300.0 35833.0 33105.0 33204.0 27701.0 True False 29794.688456650198 29068.65978774758 32832.34760310328 27752.11097610867 30711.409107455976 28784.84534946662 37499.30550174248 33201.3300691722 39845.72779727576 26901.200154158465 1.107559822086393 1.080571112856244 1.2204789159946814 1.0316309613353316 1.1416371363159616 1.0700208609472384 1.3939640345728488 1.2341951243405713 1.4811877376822644 1.0 14.715382917306407 -7.250496548198065 24.922608535513127 1.2968529863891083 1.1104552021111762 0.2979434720540787 0.12541321439820238 749.6823836213529 1707425.9592844509 0.04447275850695184 0.034122972042702635 5.6169874275752104e-08 7.250496548198065 -0.18639778427793208 SSS(ph)PAGETEGDREPQARPGEGTAPLPPPGQK ddPTM_A459_Selumetinib_30min_R1 1 SSSPAGETEGDREPQARPGEGTAPLPPPGQK 31 2 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(0.113)S(0.131)S(0.486)PAGET(0.265)EGDREPQARPGEGT(0.005)APLPPPGQK 82.042 1.0137e-05 44989000.0 1263.4 1439.3 1580.4 1696.7 1420.5 1074.3 1423.7 1305.4 694.85 883.83 True False 1292.8347618515413 1270.786086887584 1365.7903605158021 1400.4031960035734 1292.0160258096441 1063.4935173863562 1316.3091627725548 1270.7765514632058 1179.1097001639355 997.2781897332408 1.2963632165638337 1.2742543655020702 1.3695179284740335 1.4042252306532077 1.295542245995816 1.0663960450903145 1.3199016847291636 1.2742448040532426 1.1823277720325283 1.0 9.961852188847809 -6.53900330422717 24.866223581065462 1.1935941688343354 1.3360388877681522 0.41384758400520294 0.09349054482686617 257.94975819967823 397790.1062478363 0.03061871023924288 0.03062696465042894 2.890657889392805e-07 6.53900330422717 0.14244471893381672 SSS(ph)PALIETK ddPTM_A459_Selumetinib_30min_R2 1 SSSPALIETK 10 0 H7C1A6;C9JLX3;U3KQ91;A0A0A0MSC1;O60266-2;O60266 H7C1A6 ADCY3 Adenylate cyclase type 3 1 S(0.004)S(0.025)S(0.971)PALIETK 105.2 0.012654 2506200.0 70195.0 19805.0 46965.0 54562.0 29650.0 26338.0 76584.0 49207.0 40239.0 32724.0 True False 66293.84291284907 21323.979816887946 43943.32303162568 47130.561475300114 25925.101925636878 29965.82042744076 80145.30774831705 49350.18422334262 48287.92437159915 31779.17309283714 2.086078285271411 0.6710048670742241 1.3827711282245503 1.4830644377566606 0.8157890656846657 0.9429389600510059 2.5219444040972037 1.5529096392525674 1.5194833493789992 1.0 14.955793965205553 SSS(ph)PAPADIAQTVQEDLR ddPTM_A459_Selumetinib_30min_R1 25 SSSPAPADIAQTVQEDLR 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 S(0.006)S(0.209)S(0.785)PAPADIAQTVQEDLR;S(0.114)S(0.2)S(0.686)PAPADIAQTVQEDLR;SS(0.002)S(0.998)PAPADIAQTVQEDLR;SS(0.022)S(0.978)PAPADIAQTVQEDLR;S(0.027)S(0.027)S(0.945)PAPADIAQTVQEDLR;S(0.023)S(0.023)S(0.954)PAPADIAQTVQEDLR;S(0.072)S(0.023)S(0.904)PAPADIAQTVQEDLR;SS(0.001)S(0.999)PAPADIAQTVQEDLR;SS(0.027)S(0.973)PAPADIAQTVQEDLR;S(0.022)S(0.022)S(0.955)PAPADIAQT(0.001)VQEDLR;S(0.035)S(0.035)S(0.93)PAPADIAQTVQEDLR;S(0.001)S(0.012)S(0.988)PAPADIAQTVQEDLR;SS(0.005)S(0.994)PAPADIAQTVQEDLR;SS(0.009)S(0.991)PAPADIAQTVQEDLR;SS(0.027)S(0.973)PAPADIAQTVQEDLR;SS(0.002)S(0.998)PAPADIAQTVQEDLR;S(0.115)S(0.178)S(0.708)PAPADIAQTVQEDLR;SS(0.001)S(0.999)PAPADIAQTVQEDLR;SS(0.188)S(0.811)PAPADIAQTVQEDLR;S(0.073)S(0.073)S(0.854)PAPADIAQTVQEDLR;S(0.002)S(0.002)S(0.997)PAPADIAQTVQEDLR;SS(0.026)S(0.974)PAPADIAQTVQEDLR;S(0.022)S(0.022)S(0.956)PAPADIAQTVQEDLR;S(0.402)S(0.187)S(0.411)PAPADIAQTVQEDLR;S(0.049)S(0.009)S(0.942)PAPADIAQTVQEDLR 354.36 5.387999999999996e-184 27903868900.0 41094.149999999994 50248.77999999999 54054.25 56337.829999999994 49151.450000000004 42644.26 44405.47 42142.77999999999 25586.879999999997 35210.04000000001 True False 42051.56373970358 44365.62947757596 46713.97974874163 46499.48558254613 44705.71002589331 42215.297462290095 41055.929646850986 41025.01657535814 43419.066568224196 39729.59160883317 1.058444399673974 1.116689794206494 1.175798135774333 1.1703992842505784 1.1252496745009024 1.062565602937239 1.0333841347043429 1.0326060478869092 1.0928646585576967 1.0 15.277926343201 -6.806165616725063 3.4986730705801157 1.043122310740163 1.1344181241120035 0.5735161516813131 0.036962057661724494 0.18255593573873763 4.596646355019683 0.01418784379105129 0.012869358932794613 1.562551655244677e-07 6.806165616725063 0.09129581337184045 SSS(ph)PAPADIAQTVQEDLR ddPTM_A459_Selumetinib_30min_R2 34 SSSPAPADIAQTVQEDLR 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 S(0.005)S(0.094)S(0.9)PAPADIAQTVQEDLR;S(0.001)S(0.016)S(0.983)PAPADIAQTVQEDLR;S(0.011)S(0.011)S(0.978)PAPADIAQTVQEDLR;S(0.027)S(0.04)S(0.932)PAPADIAQTVQEDLR;SS(0.006)S(0.993)PAPADIAQTVQEDLR;S(0.214)S(0.059)S(0.727)PAPADIAQTVQEDLR;S(0.001)S(0.013)S(0.987)PAPADIAQTVQEDLR;S(0.002)S(0.078)S(0.92)PAPADIAQTVQEDLR;S(0.005)S(0.225)S(0.77)PAPADIAQTVQEDLR;S(0.015)S(0.015)S(0.969)PAPADIAQTVQEDLR;SS(0.021)S(0.979)PAPADIAQTVQEDLR;S(0.135)S(0.135)S(0.731)PAPADIAQTVQEDLR;S(0.001)S(0.004)S(0.995)PAPADIAQTVQEDLR;S(0.204)S(0.057)S(0.739)PAPADIAQTVQEDLR;S(0.022)S(0.022)S(0.956)PAPADIAQTVQEDLR;S(0.032)S(0.01)S(0.959)PAPADIAQTVQEDLR;SS(0.004)S(0.996)PAPADIAQTVQEDLR;S(0.006)S(0.006)S(0.989)PAPADIAQTVQEDLR;SS(0.206)S(0.793)PAPADIAQTVQEDLR;S(0.006)S(0.006)S(0.988)PAPADIAQTVQEDLR;S(0.03)S(0.03)S(0.888)PAPADIAQT(0.053)VQEDLR;S(0.184)S(0.184)S(0.631)PAPADIAQTVQEDLR;S(0.003)S(0.013)S(0.985)PAPADIAQTVQEDLR;S(0.004)S(0.004)S(0.991)PAPADIAQTVQEDLR;S(0.005)S(0.015)S(0.98)PAPADIAQTVQEDLR;S(0.012)S(0.012)S(0.977)PAPADIAQTVQEDLR;S(0.035)S(0.035)S(0.93)PAPADIAQTVQEDLR;S(0.042)S(0.042)S(0.914)PAPADIAQT(0.002)VQEDLR;S(0.078)S(0.264)S(0.658)PAPADIAQTVQEDLR;SS(0.001)S(0.999)PAPADIAQTVQEDLR;SS(0.023)S(0.977)PAPADIAQTVQEDLR;S(0.01)S(0.01)S(0.98)PAPADIAQTVQEDLR;S(0.03)S(0.03)S(0.939)PAPADIAQTVQEDLR;S(0.001)S(0.035)S(0.964)PAPADIAQTVQEDLR 382.25 4.562999999999995e-256 16037714990.0 6738979.9 7451185.0200000005 9037318.299999999 7934151.599999999 9562349.599999998 6679809.2 6871340.3 7486072.9 6021101.8 8627340.0 True False 6364454.375431972 8022666.95169795 8455867.079666186 6853506.4649050785 8361041.754757932 7599892.284029411 7190871.239252492 7507856.132752913 7225490.403640736 8378246.277678685 0.7596404025969187 0.9575592177412988 1.0092645643748022 0.8180120561941684 0.9979465245648617 0.9070982198598095 0.8582788093028971 0.8961130866677117 0.8624108392338478 1.0 22.998216862022716 -7.096812594919732 0.007091109604570583 1.8180593745391451 1.554856336429276e-06 0.07719167124133186 0.07687877295349199 16894.36215941155 61.45147301496741 7766.613338146131 7983.74095760432 8.001794708784833e-08 7.096812594919732 -1.8180578196828088 SSS(ph)PATEQSWMENDFDELR ddPTM_A459_Selumetinib_30min_R1 2 SSSPATEQSWMENDFDELR 19 0 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 S(0.004)S(0.007)S(0.988)PATEQSWMENDFDELR;S(0.017)S(0.009)S(0.972)PAT(0.002)EQSWMENDFDELR 297.55 4.3047999999999976e-100 15420200.0 3082.0 3653.0 2274.89 2362.43 2484.2 2392.5 3390.2 2627.7 1586.67 3004.3999999999996 True False 3153.8046034719437 3225.3050617663716 1965.9724330763054 1949.8759488033952 2259.5045486211334 2368.433622216194 3134.474484534322 2558.004860027472 2692.4631042082633 3390.0440053342277 0.9303137653993394 0.9514050722325021 0.5799253431468299 0.57517717933315 0.6665118638772262 0.6986439168605093 0.9246117394353089 0.7545639100856675 0.7942265941007485 1.0 11.727088285417633 -9.107408672698776 0.6661298519209299 1.0042712237137965 0.7424147367066002 0.2338742007857597 0.13072224436737648 3.324560078595767 2.3288363627451796 0.18709061852199976 0.056324165543641634 7.808926359126947e-10 9.107408672698776 -0.2618564870071963 SSS(ph)PATEQSWMENDFDELR ddPTM_A459_Selumetinib_30min_R2 2 SSSPATEQSWMENDFDELR 19 0 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 S(0.065)S(0.065)S(0.839)PAT(0.031)EQS(0.001)WMENDFDELR;S(0.074)S(0.095)S(0.763)PAT(0.068)EQSWMENDFDELR 88.385 0.0031463000000000003 3949500.0 12594.3 7713.3 11026.199999999999 11513.3 12330.400000000001 9323.9 13923.6 13895.5 11902.6 10525.3 True False 11894.35922497748 8304.885307831444 10316.786296418844 9945.168678449698 10781.344916825392 10608.182591062909 14571.074989089993 13935.933604476148 14283.45258643098 10221.407240986387 1.1636713951952518 0.8124992099453817 1.009331303722055 0.9729745077146509 1.0547808792505335 1.037839735856097 1.4255449025318214 1.3634065521423546 1.3974056849194276 1.0 13.319306213773112 -7.174586017848081 5.51267817383509 1.3260028248364066 0.9967591128671344 0.5081230319870071 0.13763951554063872 0.16029221826080525 7.86201922920413 0.05063107769680024 0.03888785201039755 6.689813062013283e-08 7.174586017848081 -0.32924371196927227 SSS(ph)PATEQSWMENDFDELREEGFR ddPTM_A459_Selumetinib_30min_R1 1 SSSPATEQSWMENDFDELREEGFR 24 1 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 S(0.027)S(0.035)S(0.935)PAT(0.001)EQS(0.001)WMENDFDELREEGFR 145.61 1.1634e-09 6809500.0 631.62 849.13 645.93 548.88 651.28 618.93 727.11 613.4 299.35 734.66 True False 646.3355170814239 749.7134648501727 558.2162538395164 453.02841175366376 592.3718389928233 612.7041261434769 672.2635073003805 597.1306393959939 507.97508634104355 828.960767194396 0.7796937354091386 0.9044016249255867 0.6733928503381289 0.5465016315391269 0.7145957473930835 0.7391231894087869 0.8109714402717094 0.7203364296925325 0.612785437434243 1.0 9.69516001367493 -7.007883966751873 20.591975921211006 0.764479337738125 0.7216885206180235 0.043223873510173316 0.12345567725433355 194.6734527510711 508470.7815133589 0.046766034969362276 0.039289381336509145 9.820102779713335e-08 7.007883966751873 -0.042790817120101576 SSS(ph)PATEQSWMENDFDELREEGFR ddPTM_A459_Selumetinib_30min_R2 2 SSSPATEQSWMENDFDELREEGFR 24 1 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 S(0.033)S(0.033)S(0.494)PAT(0.006)EQS(0.434)WMENDFDELREEGFR;S(0.055)S(0.055)S(0.877)PAT(0.005)EQS(0.007)WMENDFDELREEGFR 118.09 8.2707e-08 7586700.0 4768.3 5630.799999999999 6665.299999999999 5512.6 5663.9 3256.6400000000003 4865.4 6103.1 4550.8 3363.0 True False 4503.296975017281 6062.664254124344 6236.46185462993 4761.77437023458 4952.350246091558 3705.212599165494 5091.6507406072 6120.859010577405 5461.087159975985 3265.9014518766453 1.3788833010958141 1.8563524783151766 1.9095682911823157 1.4580275738260196 1.516380796868763 1.1345145142197761 1.5590337968346981 1.8741713737443761 1.6721530764003754 1.0 11.673265543095717 -5.786846527516066 24.973730277148842 1.4886225942815214 1.7290765526635736 0.15281236671974952 0.2691750390016678 438.5996878878004 431115.9452233098 0.07813360757973528 0.11593862115150314 1.633629143411404e-06 5.786846527516066 0.2404539583820522 SSS(ph)PATEQSWMENDFDELREEGFRR ddPTM_A459_Selumetinib_30min_R1 1 SSSPATEQSWMENDFDELREEGFRR 25 2 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 S(0.307)S(0.307)S(0.376)PAT(0.01)EQSWMENDFDELREEGFRR 61.959 0.001966 22454000.0 1303.6 1410.0 1855.0 1610.7 1158.3 1487.7 1389.5 1387.6 692.34 1184.4 True False 1333.9713436359577 1244.9165445087833 1603.101188785632 1329.421481583636 1053.5319695144744 1472.735088723524 1284.6888963071328 1350.7963404399752 1174.8504134870827 1336.4292770329714 0.9981608204494962 0.9315244479473265 1.1995406089461789 0.9947563289956551 0.7883185347850491 1.1019925364050445 0.9612846099565341 1.0107503357296246 0.879096584965115 1.0 10.38416777778106 -5.995233065831519 24.99465135716201 0.9582468184202515 1.0427915700420847 0.1306299849745738 0.09962676629270306 286.79290103815924 1503724.5637977363 0.027930189306514284 0.04125425119332611 1.0110367318312424e-06 5.995233065831519 0.08454475162183317 SSS(ph)PCRTPEPDNDAHLR ddPTM_A459_Selumetinib_30min_R1 1 SSSPCRTPEPDNDAHLR 17 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 S(0.121)S(0.121)S(0.747)PCRT(0.01)PEPDNDAHLR 107.13 0.0010609000000000005 4178700.0 742.38 980.5 1063.1 1185.4 1032.6 708.32 754.31 876.99 535.83 566.84 True False 759.6760095799807 865.7026041779171 918.7368591902989 978.3921427138769 939.2015123203367 701.1949439031032 697.4117894015346 853.7293763350058 909.2643745252096 639.5994354891673 1.18773714832781 1.3535074550461814 1.4364253753408125 1.529695131712554 1.4684214216074676 1.0963032563761217 1.0903883754496317 1.3347875701017018 1.4216153487218166 1.0 9.321024855270052 -6.7541322233100995 24.999817520955887 1.203403719741537 1.4026104298164832 0.3440620388998349 0.1416689250874202 221.59978180164177 758153.9675796302 0.050252737652106465 0.049274807269436144 1.761439684902716e-07 6.7541322233100995 0.19920671007494617 SSS(ph)PEDPERDEEVLNHVLR ddPTM_A459_Selumetinib_30min_R1 3 SSSPEDPERDEEVLNHVLR 19 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 S(0.135)S(0.135)S(0.729)PEDPERDEEVLNHVLR;S(0.151)S(0.151)S(0.697)PEDPERDEEVLNHVLR;S(0.167)S(0.167)S(0.666)PEDPERDEEVLNHVLR 99.407 0.00075106 19047500.0 1306.17 1556.65 1503.3600000000001 1579.3799999999999 1541.33 1270.1599999999999 1632.79 1699.73 843.51 1348.21 True False 1336.6012196356096 1374.3966943330477 1299.2119693653729 1303.570931634421 1401.9169736439128 1257.3833436130074 1509.627335733229 1654.6476388988467 1431.3748624671232 1521.2658861774921 0.8786111828183486 0.9034559354949548 0.8540334606660526 0.8568988126789088 0.9215463163816359 0.826537527093606 0.9923494304644487 1.0876781330162506 0.9409103796205939 1.0 10.57105661336268 -7.368141409285348 5.695225240797786 1.0156305224289475 0.8757278924930717 0.7060102005486673 0.04159860756124417 0.11819895134802738 5.3098044701139875 0.016728065896748724 0.011143604152356741 4.284090047517381e-08 7.368141409285348 -0.13990262993587577 SSS(ph)PEDPERDEEVLNHVLR ddPTM_A459_Selumetinib_30min_R2 1 SSSPEDPERDEEVLNHVLR 19 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 S(0.312)S(0.312)S(0.375)PEDPERDEEVLNHVLR 55.621 0.031153 3053800.0 8000.6 6407.2 7578.3 6364.2 5721.4 3427.3 3229.7 6649.2 4776.3 5515.1 True False 7555.958680939379 6898.611637604867 7090.720428629172 5497.384981142639 5002.626582035035 3899.379465068255 3379.8874495291384 6668.54807116568 5731.693460972417 5355.864733049322 1.4107822093254117 1.2880481456217048 1.3239170109869676 1.026423417159892 0.9340464764103231 0.728057869162833 0.6310628848919462 1.245092698106472 1.0701714376025921 1.0 12.386903809285617 -5.835524575802931 2.749272718307584 0.9230363276316685 1.3470339716820183 0.5570947267625632 0.16213111233484068 0.21793401210079216 3.3393865927108797 0.053014054324026984 0.08933307548768138 1.4604121054820397e-06 5.835524575802931 0.4239976440503498 SSS(ph)PEDPGAEV ddPTM_A459_Selumetinib_30min_R2 2 SSSPEDPGAEV 11 0 Q9Y5U2-2;Q9Y5U2 Q9Y5U2-2 TSSC4 Protein TSSC4 1 S(0.015)S(0.015)S(0.971)PEDPGAEV;S(0.099)S(0.099)S(0.802)PEDPGAEV 124.67 0.0035061 8265700.0 115626.0 111339.0 153878.0 141369.0 172349.0 99769.0 100929.0 114836.0 91170.0 119074.0 True False 109199.96980755143 119878.34328868917 143977.65700969897 122114.29832487243 150696.97780039095 113511.27413719105 105622.39848701945 115170.1537478767 109406.54750263889 115636.02422859329 0.9443421333103009 1.0366868291122628 1.2450934556957698 1.05602297501575 1.3032009601306247 0.981625534900768 0.9134039257370302 0.9959712340179074 0.9461285808854881 1.0 16.819231386805306 -6.966857292775523 24.99988700893025 0.9612506849262639 1.1189335191481198 0.36848248282866125 0.09813268687641559 202.85129554992076 153012.28138168075 0.03482254982889823 0.030710424408173728 1.079301317553455e-07 6.966857292775523 0.15768283422185592 SSS(ph)PELVTHLK ddPTM_A459_Selumetinib_30min_R1 2 SSSPELVTHLK 11 0 E9PNR6;H0YE29;Q07960 E9PNR6 ARHGAP1 Rho GTPase-activating protein 1 1 S(0.001)S(0.224)S(0.775)PELVTHLK;S(0.305)S(0.305)S(0.389)PELVTHLK 182.71 3.4916e-05 44578000.0 14523.1 16556.1 16241.2 16374.3 15934.3 13633.6 15979.900000000001 14254.699999999999 7566.9 12424.0 True False 14861.459972966699 14617.704115277918 14035.734246525719 13514.835888678794 14493.045378429164 13496.458362318368 14774.523277508702 13876.619050208781 12840.476635490362 14018.741420008137 1.0601137097625468 1.0427258537214272 1.0012121506495104 0.9640548665367243 1.033833562101665 0.9627439409828656 1.0539122475304297 0.989861973657884 0.9159507441348405 1.0 13.77506921187817 -5.2255247462612315 3.012840933215589 0.9911407141354629 1.0566723637840874 0.32145493020037563 0.03616897618421494 0.31945957871211844 5.745725437576334 0.009595537495360835 0.03024056208010481 5.949428557277742e-06 5.2255247462612315 0.06553164964862446 SSS(ph)PELVTHLK ddPTM_A459_Selumetinib_30min_R2 1 SSSPELVTHLK 11 0 E9PNR6;H0YE29;Q07960 E9PNR6 ARHGAP1 Rho GTPase-activating protein 1 1 S(0.384)S(0.162)S(0.454)PELVTHLK 142.1 0.00062778 24241000.0 103700.0 89517.0 110560.0 116290.0 125770.0 84567.0 94298.0 92982.0 83177.0 102580.0 True False 97936.76914399095 96382.66605747826 103446.68996862644 100451.10138856064 109969.64820193432 96215.33662720727 98683.04384794229 93252.5622260012 99814.7241595592 99618.24886515188 0.9831207661215059 0.967520179841211 1.038431122280185 1.0083604413136809 1.1039106735433044 0.965840473239487 0.9906121114568524 0.9360991915470469 1.001972282153577 1.0 16.60412243043381 SSS(ph)PFLSK ddPTM_A459_Selumetinib_30min_R2 3 SSSPFLSK 8 0 Q9NYV4;J3QSD7;Q9NYV4-3;Q9NYV4-2 Q9NYV4;Q9NYV4-2 CDK12 Cyclin-dependent kinase 12 1 S(0.094)S(0.094)S(0.811)PFLS(0.001)K;S(0.001)S(0.024)S(0.975)PFLSK;S(0.093)S(0.093)S(0.813)PFLS(0.001)K 122.94 0.0061569 33909900.0 555470.0 451050.0 525210.0 540390.0 566730.0 430040.0 456360.0 474710.0 416871.0 467280.0 True False 524599.2011225899 485644.0846456614 491418.5604054102 466787.94977525464 495532.31076951744 489274.1064855577 477581.6442601852 476091.3275075289 500256.8483489387 453788.412260754 1.1560436250653905 1.0701993958510396 1.0829244359880952 1.028646693399987 1.0919897850647997 1.0781987667953343 1.0524324362556865 1.0491482696432524 1.1024011077248117 1.0 18.791660243897944 -4.737099514062449 0.009460522389844801 2.214684954144419e-09 2.1928757617525205 0.3950339112280047 0.03160410264944476 7997.604203278872 11.675220970535339 1261.000632502867 1449.8524765693676 1.83189461468249e-05 4.737099514062449 2.1928757595378356 SSS(ph)PGKLLGSGYGGLTGGSSR ddPTM_A459_Selumetinib_30min_R1 1 SSSPGKLLGSGYGGLTGGSSR 21 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.021)S(0.021)S(0.959)PGKLLGSGYGGLTGGSSR 160.02 5.1675e-07 20972000.0 2559.8 1486.7 9308.1 8684.4 4393.8 3228.1 2161.5 2457.5 2068.8 1572.2 True False 2619.4383594962605 1312.6364728519206 8044.111145733446 7167.832566377924 3996.3815657883943 3195.6282448802885 1998.4563147663673 2392.319116914988 3510.6025008262914 1774.0071845248547 1.4765658123294714 0.7399273713784275 4.534429857953455 4.04047550027129 2.2527426047932124 1.8013615011013595 1.1265209815379797 1.3485397002807182 1.9789110954286027 1.0 10.792796137061712 -6.759507991234989 3.051795868477669 1.4131816415593215 2.723109126221773 0.2394478794602105 1.0584685272555505 0.41695166615205903 8.016331410152365 0.4300159640388177 0.4004334039575421 1.7397706850957738e-07 6.759507991234989 1.3099274846624516 SSS(ph)PGKPQAVSSLNSSHSR ddPTM_A459_Selumetinib_30min_R1 2 SSSPGKPQAVSSLNSSHSR 19 1 Q9UHB7;Q9UHB7-2;Q9UHB7-3 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 S(0.126)S(0.126)S(0.748)PGKPQAVSSLNSSHSR;S(0.147)S(0.147)S(0.705)PGKPQAVSSLNSSHSR 157.7 1.1731999999999998e-06 77441000.0 13013.8 13062.9 11950.7 14844.0 21140.7 12932.099999999999 18783.7 12205.5 2446.8 6383.799999999999 True False 13316.99621955327 11533.489595222549 10327.860580496197 12251.774056390079 19228.52741769373 12802.014815407327 17366.830386156365 11881.770490948478 4152.040892798615 7203.222913477781 1.8487552557392264 1.6011568340669435 1.4337832806995296 1.7008739287334942 2.669433897667624 1.7772620629931886 2.4109805561704465 1.649507537621358 0.5764143276796042 1.0 12.814426835792164 -8.145140278052835 4.674266491724598 0.8014735613085558 1.911013600216707 0.5998071962849945 0.3632964475871559 0.1580847487843462 5.21195178830665 0.2793784699599003 0.09872170976644516 7.1591213170304705e-09 8.145140278052835 1.1095400389081513 SSS(ph)PGKPQAVSSLNSSHSR ddPTM_A459_Selumetinib_30min_R2 3 SSSPGKPQAVSSLNSSHSR 19 1 Q9UHB7;Q9UHB7-2;Q9UHB7-3 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 S(0.169)S(0.047)S(0.784)PGKPQAVSSLNSSHSR;S(0.162)S(0.162)S(0.676)PGKPQAVSSLNSSHSR;S(0.293)S(0.293)S(0.413)PGKPQAVSSLNSSHSR 92.551 0.0012242000000000002 49082400.0 73646.1 59984.1 133508.0 188868.0 195802.0 121613.0 98440.9 95567.0 115174.0 160889.0 True False 69553.14459069684 64584.687590718924 124918.2406325197 163143.85258452696 171203.6022679106 138364.0868571021 103018.59690694287 95845.08414803147 138212.0182304373 156243.71653017597 0.44515802705745144 0.4133586234697984 0.7995088916640929 1.0441626467136573 1.0957471191159573 0.8855657682104567 0.6593455352621908 0.6134332072773021 0.884592489860185 1.0 17.253438646208124 -5.308003853752262 4.529983018829033 0.8696479965605569 0.4251607332176873 0.6011132656428528 0.1452652877285231 0.1505466137799453 6.9486376543631465 0.044217454930958536 0.10185116491121085 4.920351695424839e-06 5.308003853752262 -0.4444872633428696 SSS(ph)PIPLTPSK ddPTM_A459_Selumetinib_30min_R1 3 SSSPIPLTPSK 11 0 Q8N5Y2;Q8N5Y2-3;Q8N5Y2-2;A0A3B3IT59;Q8N5Y2-6;Q8N5Y2-4;A0A3B3ITL5;A0A3B3ITF3;A0A3F2YNX2;A0A3B3IRN2 Q8N5Y2 MSL3 Male-specific lethal 3 homolog 1 S(0.001)S(0.001)S(0.998)PIPLTPSK;S(0.001)S(0.229)S(0.769)PIPLTPSK;S(0.008)S(0.066)S(0.926)PIPLTPSK 176.32 7.1056e-05 52861900.0 27626.1 32126.7 37207.0 38917.5 32916.9 28622.2 31010.4 29922.0 16482.899999999998 24926.9 True False 28269.734378966972 28365.291028702355 32154.493763421557 32121.289196952344 29939.572206950706 28334.2866548783 28671.26056138373 29128.37135964609 27970.277436615284 28126.510423567346 1.0050921338354017 1.0084895211506555 1.1432094945016409 1.1420289510936896 1.064460957156782 1.0073872026135477 1.0193678536588007 1.0356198092472673 0.9944453476595819 1.0 14.779642952219737 -6.6880305872460175 5.1426615409267145 1.0141106117975796 1.0779220709169717 0.321909662557459 0.0443564282226127 0.2846993844762066 13.669735049102648 0.016720306330670842 0.016512336793706037 2.0510177211004692e-07 6.6880305872460175 0.06381145911939212 SSS(ph)PIPLTPSK ddPTM_A459_Selumetinib_30min_R2 3 SSSPIPLTPSK 11 0 Q8N5Y2;Q8N5Y2-3;Q8N5Y2-2;A0A3B3IT59;Q8N5Y2-6;Q8N5Y2-4;A0A3B3ITL5;A0A3B3ITF3;A0A3F2YNX2;A0A3B3IRN2 Q8N5Y2 MSL3 Male-specific lethal 3 homolog 1 SS(0.017)S(0.983)PIPLTPSK;SS(0.002)S(0.998)PIPLTPSK;S(0.001)S(0.256)S(0.743)PIPLTPSK 181.66 4.0868e-05 55945300.0 461479.0 459172.0 543637.0 544844.0 594740.0 397110.0 450337.0 476720.0 373231.0 458436.0 True False 435831.84462680604 494389.01592931536 508659.98728721234 470635.3072916764 520023.4441569394 451808.297894335 471278.5628258368 478107.17627475597 447887.6289454594 445199.76152022724 0.9789579471888473 1.1104880520176408 1.142543260917946 1.0571328827414332 1.1680676610904084 1.0148439800406486 1.058577752190518 1.0739160655481026 1.0060374412961361 1.0 18.76409329430968 -8.070589269873215 0.8439203671151841 0.998139866876032 1.0873372178994862 0.21590976527048678 0.05338889520956654 0.8731301443009533 1.2402907774472827 0.049478186879000255 0.0194543091927492 8.499839597693677e-09 8.070589269873215 0.08919735102345427 SSS(ph)PIRLPEMSGGQTNR ddPTM_A459_Selumetinib_30min_R2 1 SSSPIRLPEMSGGQTNR 17 1 Q9Y2I7 Q9Y2I7 PIKFYVE 1-phosphatidylinositol 3-phosphate 5-kinase 1 S(0.037)S(0.037)S(0.919)PIRLPEMS(0.004)GGQT(0.004)NR 53.327 0.047951 6254200.0 16479.0 14213.0 17645.0 21710.0 20549.0 12179.0 12472.0 13573.0 11995.0 17635.0 True False 15563.1631506637 15303.091398001932 16509.73991042341 18753.060548161076 17967.450909609175 13856.546700045606 13051.97271279916 13612.495182868886 14394.335168302689 17125.83172876735 0.9087537117698795 0.8935677776336174 0.9640255826343868 1.0950160462373555 1.0491432588017378 0.8091021165862493 0.7621219757096486 0.7948516252208127 0.8405042976174761 1.0 14.063886434882747 -6.773303886489466 24.99989628915491 0.823544567612907 0.9824515857439333 0.4171794948777483 0.08186485221422853 210.31872167273326 443163.36538524553 0.03022946308708435 0.02686846900107629 1.685373315699324e-07 6.773303886489466 0.15890701813102637 SSS(ph)PPILTKPTLK ddPTM_A459_Selumetinib_30min_R1 2 SSSPPILTKPTLK 13 1 A0A3F2YNX6;Q92794;A0A3B3ITI3;A0A3B3IS53 A0A3F2YNX6 KAT6A Histone acetyltransferase KAT6A 1 S(0.107)S(0.107)S(0.786)PPILTKPTLK;S(0.215)S(0.215)S(0.57)PPILTKPTLK 97.957 0.007120100000000002 49180000.0 13902.5 14670.2 12856.0 12284.5 14295.9 12351.9 15993.599999999999 15106.400000000001 7686.0 14039.8 True False 14226.401200444085 12952.60616400905 11110.225812953146 10139.242683624621 13002.838369146142 12227.65110062788 14787.189875478762 14705.729199497295 13042.580636770534 15841.945089232955 0.8980211154824113 0.8176146357692115 0.7013170258053891 0.6400251122266419 0.8207854714749375 0.7718528900178081 0.9334200940722196 0.9282780060569775 0.823294144961718 1.0 13.951461861325006 -7.256241398907024 23.675694791102487 0.9152712341072434 0.769481396444947 0.4638260437641878 0.07682422733539487 204.2169996756099 930168.8001774333 0.031707383033277366 0.02376182021160022 5.5431751461859134e-08 7.256241398907024 -0.14578983766229647 SSS(ph)PPPR ddPTM_A459_Selumetinib_30min_R2 1 SSSPPPR 7 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 SS(0.002)S(0.998)PPPR 113.26 0.014215 5602200.0 32199.0 33678.0 36658.0 28162.0 31507.0 24645.0 37469.0 82698.0 36849.0 42547.0 True False 30409.50848280967 36260.994308162175 34299.464190212595 24326.287017840285 27548.808983846215 28039.62504496461 39211.38274341497 82938.63748860912 44219.82964708512 41318.557559618064 0.7359770107882432 0.8775958419129615 0.8301224973965342 0.5887496673314447 0.666741788943052 0.6786206174914641 0.9490017333455392 2.007297504733507 1.0702171677527912 1.0 15.334502269814632 -7.536828939046502 24.999908340305744 1.4188845843625784 0.7385105632183847 0.5267479317885783 0.264985432788742 160.14633093632963 286991.9241033191 0.1165374713978676 0.06732183101237836 2.9051667231811306e-08 7.536828939046502 -0.6803740211441937 SSS(ph)PRGEASSLNGESH ddPTM_A459_Selumetinib_30min_R1 4 SSSPRGEASSLNGESH 16 1 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 S(0.029)S(0.029)S(0.94)PRGEAS(0.001)S(0.002)LNGESH;SS(0.002)S(0.998)PRGEASSLNGESH;SS(0.002)S(0.998)PRGEASSLNGESH;SS(0.002)S(0.906)PRGEAS(0.01)S(0.082)LNGESH 298.7 2.982499999999999e-87 76220800.0 3530.48 3592.2999999999997 8263.5 8975.2 7341.5 4881.72 4036.57 3314.9300000000003 1736.0500000000002 2088.6299999999997 True False 3612.7333148817715 3171.7118459850376 7141.36208815637 7407.849805369993 6677.462621247097 4832.614329047118 3732.0882750388505 3227.0072879898303 2945.950053924732 2356.726005479038 1.5329458352318865 1.3458127243520368 3.0302046447290705 3.1432800368595424 2.8333639997704387 2.0505626525153993 1.5835902291408925 1.3692755460276322 1.250018053467325 1.0 11.202568324321826 -7.319151223009264 2.127982014687708 1.2400543489990357 2.39680933393917 0.4608885034536778 0.5577884311695652 0.3488681969613386 3.085101436183416 0.32807370818949116 0.20210630561554946 4.795664326838977e-08 7.319151223009264 1.1567549849401342 SSS(ph)PRGEASSLNGESH ddPTM_A459_Selumetinib_30min_R2 1 SSSPRGEASSLNGESH 16 1 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 SS(0.003)S(0.997)PRGEASSLNGESH 224.67 9.5214e-11 6790900.0 8350.7 12073.0 12502.0 12929.0 13893.0 4773.6 3386.9 3573.6 3045.0 11131.0 True False 7886.601524500726 12998.960279186475 11697.63493114839 11168.047896230986 12147.637135004148 5431.12006957367 3544.3975610150305 3583.9985843586705 3654.0850844086444 10809.619108188792 0.7295910656580171 1.2025363844077683 1.0821505192802663 1.0331583180179464 1.1237803120927494 0.5024339909867261 0.32789291884762006 0.33155641734347735 0.3380401333142723 1.0 13.40002806817165 -6.796716066090065 6.633010459793166 0.4436278258052233 1.0464421637970558 0.5917636626552012 0.21941215834711983 0.11351065684835222 14.36020243163708 0.07310463879537518 0.06553859917545724 1.5969228454172384e-07 6.796716066090065 0.6028143379918325 SSS(ph)PSASLTENEVK ddPTM_A459_Selumetinib_30min_R1 1 SSSPSASLTENEVK 14 0 O96028-5 O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 S(0.002)S(0.069)S(0.929)PSASLTENEVK 258.39 1.1133e-35 5684700.0 2259.3 3088.9 3509.4 3664.8 2782.9 2899.4 3180.3 2317.1 1347.3 2095.7 True False 2311.937294167475 2727.25015200935 3032.842755754336 3024.8114768161117 2531.1871863609 2870.2346684445693 2940.407410525781 2255.6429809984616 2286.2696971013456 2364.7035088466714 0.9776859067186263 1.1533158985075056 1.282546731295516 1.2791504158977598 1.0704036158830867 1.213782048238453 1.2434571182075573 0.9538798299912865 0.9668314393530122 1.0 11.207443591638475 -7.76953708464302 24.99382874944251 0.970266647628523 1.179239383454695 0.5126417588749352 0.08959755687283107 151.5661887876453 467805.5330401002 0.049910372753712906 0.024631442907527962 1.7000547788380375e-08 7.76953708464302 0.20897273582617204 SSS(ph)PSASLTENEVK ddPTM_A459_Selumetinib_30min_R2 1 SSSPSASLTENEVK 14 0 O96028-5 O96028-5 WHSC1 Histone-lysine N-methyltransferase NSD2 1 SS(0.018)S(0.982)PSASLTENEVK 265.12 1.9492e-36 16960000.0 82056.0 79139.0 85176.0 78070.0 80892.0 67240.0 65041.0 72724.0 56039.0 85382.0 True False 77495.65601619401 85208.70682800774 79695.86889261665 67436.73132173822 70729.62377634454 76501.69965605273 68065.5353762964 72935.61479989366 67248.36586048464 82916.79981092215 0.9346194763052825 1.0276410452684124 0.9611546643665663 0.8133060064488302 0.8530192185133962 0.9226320821655204 0.8208895607585969 0.8796240926592813 0.8110342658403756 1.0 16.339376815991876 -5.632633041604987 6.253788094088524 0.866048925520652 0.9841054777847416 0.3970702993260379 0.05810540691032925 0.1772637875010341 9.056478130918999 0.014770217904052795 0.025810570625654578 2.3300592164939297e-06 5.632633041604987 0.11805655226408951 SSS(ph)PTLTPSQEGSPVFAGFEGR ddPTM_A459_Selumetinib_30min_R2 2 SSSPTLTPSQEGSPVFAGFEGR 22 0 P0C860 P0C860 MSL3P1 Putative male-specific lethal-3 protein-like 2 1 S(0.013)S(0.013)S(0.962)PT(0.005)LT(0.008)PSQEGSPVFAGFEGR;S(0.024)S(0.024)S(0.948)PT(0.003)LTPSQEGSPVFAGFEGR 185.09 2.3727e-17 5482400.0 16245.7 14767.3 16618.1 18877.0 17800.9 12309.5 15383.1 15626.1 13070.699999999999 15241.0 True False 15342.829030689805 15899.904425646522 15548.909538419228 16305.920035358671 15564.591799934882 14005.02189048456 16098.444631034374 15671.569363959892 15685.205225871956 14800.952729126348 1.0366109068436598 1.074248713351917 1.0505343691707762 1.1016804346162625 1.0515939132286931 0.9462243510125197 1.0876627285860274 1.0588216617380504 1.0597429444528603 1.0 13.853402423873074 -6.526079272238663 24.99967006747059 1.0334254377037704 1.0667050507541413 0.15091022502928286 0.03930379784074837 205.91177925426715 1608383.430004418 0.013167728576357614 0.01322809932645076 2.977972807238802e-07 6.526079272238663 0.03327961305037097 SSS(ph)PTQYGLTK ddPTM_A459_Selumetinib_30min_R2 2 SSSPTQYGLTK 11 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 SS(0.087)S(0.906)PT(0.006)QYGLTK;S(0.09)S(0.09)S(0.813)PT(0.007)QYGLTK 121.68 0.0043711 456530000.0 114092.0 101243.0 127016.0 133990.0 122186.0 95980.0 109801.0 113525.0 91015.0 102824.0 True False 107751.22338646285 109008.01255244552 118843.92884456436 115740.33085435753 106835.90232330072 109200.37378030844 114906.96406655392 113855.33895492463 109220.54317157714 99855.20395116402 1.0790746913817384 1.0916608072400298 1.1901625968606215 1.1590816129218704 1.0699082080444273 1.0935872088721068 1.150735860724407 1.1402043604117782 1.0937891952530927 1.0 16.60754999518967 -8.636982333598482 4.483723364548745 1.0000083150695538 1.1224388299019175 0.4980478630549706 0.03670331731368512 0.7114564720489407 26.740120554124463 0.037955564004262164 0.00990050632188553 2.3068410253968116e-09 8.636982333598482 0.12243051483236367 SSS(ph)PTSYWK ddPTM_A459_Selumetinib_30min_R1 1 SSSPTSYWK 9 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 SS(0.008)S(0.989)PT(0.002)S(0.001)YWK 128.51 0.004305600000000001 11808000.0 3877.1 4887.0 3958.1 3666.0 4353.9 3324.1 4837.2 4495.8 2096.8 3749.5 True False 3967.4288864766586 4314.827768095337 3420.6117602870113 3025.801919342902 3960.0905137434784 3290.6625720413144 4472.326109547939 4376.556779583481 3558.1164557872057 4230.784848222835 0.9377524570040946 1.019864616823473 0.8085052497348947 0.7151869045323606 0.936017938942685 0.7777901004404836 1.0570913601117216 1.0344550565888215 0.841006239606302 1.0 12.046709605597593 -7.266633276994129 24.9920321620462 0.9860094156107126 0.8665875688889092 0.25532772479208865 0.09807184618494523 672.3706322982819 3235299.5977321896 0.042149242756435855 0.029374811910353904 5.412111346457222e-08 7.266633276994129 -0.11942184672180345 SSS(ph)PTSYWK ddPTM_A459_Selumetinib_30min_R2 4 SSSPTSYWK 9 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 SS(0.076)S(0.883)PT(0.031)S(0.009)YWK;SS(0.003)S(0.995)PT(0.001)SYWK;S(0.01)S(0.443)S(0.546)PT(0.001)S(0.001)YWK;S(0.001)S(0.005)S(0.915)PT(0.025)S(0.054)YWK 137.46 0.0025514 156266900.0 331433.0 270762.0 331293.0 348847.0 362286.0 260110.0 322565.0 364623.0 328060.0 270110.0 True False 313013.2806914211 291528.57476294914 309977.9690645455 301333.4368053588 316772.3938020668 295937.7914565125 337564.91165042156 365683.992563413 393681.1667622652 262311.2224699376 1.1932897027586926 1.1113843015098603 1.1817182892358746 1.148763037921084 1.2076204396415817 1.128193405794633 1.2868870362155722 1.394084435732911 1.5008170945007258 1.0 18.000920006231013 -7.404348232306345 4.331281799385871 1.3365190574246417 1.1623678017301518 0.20174002637353994 0.12297478721470571 0.2843872133933135 8.72942726804078 0.05123474318488758 0.03328810868299547 3.9414113936682436e-08 7.404348232306345 -0.17415125569448997 SSS(ph)PVGLAK ddPTM_A459_Selumetinib_30min_R1 3 SSSPVGLAK 9 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.027)S(0.027)S(0.946)PVGLAK;S(0.004)S(0.031)S(0.965)PVGLAK;S(0.14)S(0.024)S(0.836)PVGLAK 109.83 0.011204 340114000.0 41892.5 47071.9 52380.0 53167.0 45992.0 40205.4 45315.8 41641.0 24229.3 34714.8 True False 42868.513741384944 41560.700064867364 45267.08370274468 43882.381518195325 41832.031720547115 39800.97017958243 41897.592722040135 40536.54541096932 41115.352461944356 39170.782730787054 1.0944002328473152 1.061012754085251 1.1556338818618022 1.120283498539974 1.0679396428723493 1.0160882015844954 1.0696133648896908 1.0348668723208538 1.0496433718090838 1.0 15.257490336802679 -6.479202701548938 4.306073307492265 1.0384787821245292 1.1073093637067448 0.6009889441462297 0.02818154928209023 0.16424157835867043 6.6262518118976566 0.009356994968396697 0.010280557568326219 3.3173958608666165e-07 6.479202701548938 0.06883058158221567 SSS(ph)PVGLAK ddPTM_A459_Selumetinib_30min_R2 3 SSSPVGLAK 9 0 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 S(0.001)S(0.049)S(0.95)PVGLAK;S(0.002)S(0.017)S(0.981)PVGLAK;S(0.119)S(0.017)S(0.864)PVGLAK 117.02 0.0076638 231302900.0 472328.0 406326.0 464325.0 481677.0 514855.0 346001.0 378549.0 402504.0 324197.0 400378.0 True False 446077.9006387941 437489.8976559873 434450.83501883474 416071.76166082866 450174.31203790114 393659.4970656436 396152.2785806136 403675.22000187525 389045.45882102865 388818.0468330255 1.1472664509071986 1.125178991097251 1.117362834769359 1.0700937496337637 1.1578019994304032 1.0124517117249374 1.0188628892288472 1.0382111203167224 1.000584880228311 1.0 18.56873565704376 -6.772990836031006 24.992201072175284 1.0167128374457908 1.1203193132404696 0.8396309232182584 0.023896561925828667 87.42956655831244 189157.38057908582 0.00833217268276798 0.007408988696615257 1.6865886134133146e-07 6.772990836031006 0.10360647579467885 SSS(ph)PVQVEEEPVR ddPTM_A459_Selumetinib_30min_R1 2 SSSPVQVEEEPVR 13 0 A0A0J9YVR0;Q8IZ21-3;Q8IZ21;Q8IZ21-2 A0A0J9YVR0;Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 S(0.006)S(0.006)S(0.987)PVQVEEEPVR;S(0.001)S(0.007)S(0.993)PVQVEEEPVR 257.81 1.4709e-29 306220000.0 6383.7 7366.799999999999 6629.9 7140.299999999999 10312.5 6318.2 8606.9 7073.9 3264.05 4770.2 True False 6532.4277894821 6504.291631267591 5729.595995433885 5893.380645031123 9379.736195819753 6254.6446444666035 7957.674603545059 6886.277192734463 5538.854453220251 5382.501635682775 1.213641579999902 1.2084142414649757 1.0644856951737984 1.094914789428307 1.7426350850759984 1.1620330225265592 1.478434219283915 1.2793822759072757 1.029048354858074 1.0 12.394061137473745 -8.273262488985159 5.672579935788204 1.0088356717688804 1.2832071165606176 0.2406014763314459 0.18915505663587642 0.2503514837394265 30.660884963537157 0.16601594701959016 0.049172500531013776 5.330126435520199e-09 8.273262488985159 0.27437144479173714 SSS(ph)PVQVEEEPVR ddPTM_A459_Selumetinib_30min_R2 1 SSSPVQVEEEPVR 13 0 A0A0J9YVR0;Q8IZ21-3;Q8IZ21;Q8IZ21-2 A0A0J9YVR0;Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 S(0.008)S(0.008)S(0.984)PVQVEEEPVR 99.834 0.01142 230300000.0 38142.0 47014.0 71938.0 72399.0 86525.0 69265.0 57794.0 58342.0 64950.0 68255.0 True False 36022.220334523634 50619.82262616354 67309.58740017221 62538.131304758805 75654.95595668569 78805.62502493299 60481.5355166384 58511.76556096193 77941.81485462777 66284.3008022125 0.5434502574299049 0.7636774019418171 1.0154680155866636 0.943483306723986 1.1413706570192923 1.1889033160368276 0.9124564155411532 0.8827394247629881 1.1758714191947266 1.0 16.01637959322415 -4.931055946252356 1.5518764708345125 1.0380334037860173 0.43169262055232005 0.711938965212036 0.10141205212971288 0.45130819580848 1.2898184426112482 0.030457475642639134 0.3859318366503115 1.1720443718868964e-05 4.931055946252356 -0.6063407832336972 SSS(ph)PVT(ph)ELASRSPIR ddPTM_A459_Selumetinib_30min_R2 1 SSSPVTELASRSPIR 15 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.002)S(0.015)S(0.983)PVT(0.962)ELAS(0.034)RS(0.003)PIR 192.54 0.0028801 10565000.0 76563.0 65577.0 73660.0 75170.0 75169.0 57954.0 52415.0 49630.0 41822.0 63548.0 True False 72307.93496597279 70606.54503671078 68920.79579494405 64931.71632451718 65725.59820061372 65936.63744596788 54852.40135835211 49774.415083311236 50187.56860431471 61713.2041224671 1.1716768881823236 1.144107586710216 1.1167917267457674 1.0521527321067805 1.065016784255509 1.0684364615896391 0.8888276364568588 0.8065440093587773 0.813238743927794 1.0 15.91329158017122 -7.235041773505045 2.6288303779236064 0.8534802531816611 1.107819711332955 0.7745098955659453 0.05979582904823279 0.12932923837825425 1.769175037266337 0.027700037913704758 0.018943776571327828 5.820472296722678e-08 7.235041773505045 0.254339458151294 SSS(ph)PVTELASR ddPTM_A459_Selumetinib_30min_R1 5 SSSPVTELASR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.018)S(0.061)S(0.921)PVTELASR;S(0.008)S(0.008)S(0.945)PVT(0.039)ELASR;S(0.002)S(0.003)S(0.995)PVTELASR;SS(0.003)S(0.997)PVTELASR;S(0.006)S(0.003)S(0.991)PVTELASR 244.0 6.338800000000001e-11 485982000.0 20422.8 26785.6 19437.3 19422.8 22797.5 20167.699999999997 26164.800000000003 25374.6 11292.400000000001 21488.7 True False 20898.611504148867 23649.529499712382 16797.82142144633 16030.972591111102 20735.470150225534 19964.83124880649 24191.16807059868 24701.583179683035 19162.378035736096 24246.98396266329 0.8619056100474016 0.9753596379710195 0.6927798297434621 0.6611532640841595 0.8551772947165323 0.8233944180253235 0.9976980274268108 1.0187486912895956 0.7902994477681545 1.0 14.565517683850542 -7.181971501530215 5.77651207518691 0.9529022259829248 0.8075707806406992 0.31335909049647614 0.10155867113456199 0.3010935410003823 16.960822890179212 0.041816732345991224 0.032133077714286036 6.577009943784449e-08 7.181971501530215 -0.14533144534222564 SSS(ph)PVTELASR ddPTM_A459_Selumetinib_30min_R2 6 SSSPVTELASR 11 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SS(0.001)S(0.998)PVT(0.001)ELASR;S(0.27)S(0.179)S(0.535)PVT(0.016)ELASR;S(0.006)S(0.072)S(0.922)PVTELASR;SS(0.001)S(0.999)PVTELASR;S(0.005)S(0.017)S(0.966)PVT(0.012)ELASR;S(0.004)S(0.002)S(0.988)PVT(0.006)ELASR 197.07 1.9384e-05 688074000.0 853761.0 713656.0 891101.0 890117.0 918642.0 758800.0 837312.0 865173.0 792177.0 816696.0 True False 806312.3814960727 768391.1204342851 833768.531817409 768881.5290625276 803233.9791963206 863317.8122994181 876248.6671022519 867690.5101928994 950634.5352747419 793115.8644489585 1.016638826227846 0.9688258108014878 1.051256908593923 0.9694441424352689 1.012757423222636 1.088514113759702 1.104817979792968 1.0940274291395669 1.1986073887643445 1.0 19.597172115719836 -6.7865650649238685 3.46235399068405 1.1060469162306787 1.0012228366103557 0.46825701478410675 0.04977263338381882 0.19349332345102382 4.8499410101308795 0.0171538488564891 0.015740938981436237 1.6346882278409452e-07 6.7865650649238685 -0.10482407962032303 SSS(ph)PVTELASRS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 1 SSSPVTELASRSPIR 15 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.008)S(0.031)S(0.961)PVTELAS(0.288)RS(0.712)PIR 113.05 0.0056367 26733000.0 139530.0 123310.0 146280.0 146450.0 163350.0 118870.0 111660.0 113730.0 95617.0 152370.0 True False 131775.4811828451 132767.480495857 136868.50405762176 126503.25735965888 142828.51263247142 135243.2635055769 116852.41125009254 114060.93547098487 114743.0717622008 147970.6821951963 0.8905512850783021 0.8972553111616804 0.9249704199989491 0.8549210930363992 0.9652487270691801 0.9139868891539612 0.7896997534683665 0.7708346935950514 0.7754446357883035 1.0 17.174951833794452 -7.253944617228875 24.59530190368623 0.8148976614451776 0.908327128238838 0.20438905677422736 0.06725754174478875 552.584711601549 1813401.0661718973 0.024685080908154657 0.018717067777096103 5.572568077635957e-08 7.253944617228875 0.09342946679366038 SSS(ph)PVTELASRS(ph)PIRQDR ddPTM_A459_Selumetinib_30min_R1 1 SSSPVTELASRSPIRQDR 18 2 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.064)S(0.088)S(0.826)PVT(0.022)ELAS(0.014)RS(0.986)PIRQDR 145.17 0.0026325 23924000.0 1424.9 1459.1 2232.5 2484.9 1569.5 1663.3 1326.1 1535.3 947.21 848.55 True False 1458.097397627245 1288.2678936828129 1929.3387622447012 2050.9588623500194 1427.5390021177313 1646.5687121555677 1226.071209350765 1494.578856642759 1607.34618851879 957.4696580769395 1.5228653830720937 1.345492134205355 2.015039062563866 2.1420614690488815 1.4909495983245231 1.7197085027870975 1.2805327030553708 1.5609673309591803 1.6787437335059952 1.0 9.903082958968437 -7.2414343866140545 23.208420498364724 1.4268082418467096 1.7137223656200566 0.23946289515115715 0.27946047397066676 572.4476100495921 664114.559779343 0.11210155406660574 0.08667510584455244 5.735425110351532e-08 7.2414343866140545 0.286914123773347 SSS(ph)QENLLDEVMK ddPTM_A459_Selumetinib_30min_R1 5 SSSQENLLDEVMK 13 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.001)S(0.111)S(0.889)QENLLDEVMK;SS(0.003)S(0.997)QENLLDEVMK;SS(0.003)S(0.997)QENLLDEVMK;S(0.022)S(0.022)S(0.956)QENLLDEVMK;S(0.002)S(0.004)S(0.994)QENLLDEVMK 284.53 5.2883e-49 38144000.0 13858.5 17082.899999999998 17630.9 20096.6 17040.8 15639.4 17384.4 15872.9 8971.599999999999 14927.899999999998 True False 14181.376086053178 15082.826126375241 15236.72061960139 16587.106069903573 15499.462648797597 15482.081835439041 16073.080711739258 15451.899129554395 15224.14994026158 16844.041375059518 0.8419224205333008 0.8954398644916619 0.9045762997330296 0.9847462197797506 0.9201748145636356 0.9191429473904588 0.954229472241632 0.9173510552184687 0.9038300014391757 1.0 14.03995070395441 -4.928247580423843 1.5528381295956442 0.9373272786872764 0.8241452178669986 0.5039852256032016 0.03053591437629023 0.6788803246145402 1.936131071016504 0.008492290785450373 0.10859478861606277 1.1796479561304225e-05 4.928247580423843 -0.11318206082027782 SSS(ph)QENLLDEVMK ddPTM_A459_Selumetinib_30min_R2 5 SSSQENLLDEVMK 13 0 Q3V6T2;Q3V6T2-3;Q3V6T2-2;Q3V6T2-4;Q3V6T2-5;A0A2U3TZV9;A0A2R8Y7B1;A0A2R8Y820;A0A2R8YCU9;A0A2R8Y7D4;H7C2C6;A0A2R8Y885;A0A2R8YDS8;H0Y470;A0A2R8Y5D7;H0Y7U8;H0Y7K3;A0A2R8Y4Z5;A0A2R8Y4C6 Q3V6T2 CCDC88A Girdin 1 S(0.036)S(0.036)S(0.928)QENLLDEVMK;S(0.044)S(0.222)S(0.734)QENLLDEVMK;SS(0.034)S(0.965)QENLLDEVMK;S(0.074)S(0.226)S(0.7)QENLLDEVMK;SSS(0.999)QENLLDEVMK 175.27 5.889400000000001e-10 24593300.0 140531.4 147338.8 155691.2 150886.6 145880.5 123704.0 120786.09999999999 123055.6 111092.8 149175.5 True False 132721.22737976708 158639.21219108757 145674.19769576145 130335.5847860966 127553.6874017832 140743.10312689378 126402.8929831166 123413.67142304873 133314.46419218177 144868.41571050347 0.9161501955332305 1.0950572725810908 1.005562164681004 0.899682543961491 0.88047961852968 0.9715237268014757 0.8725358965456813 0.8519018505018469 0.9202452000206143 1.0 17.144383566469806 -5.737906465831827 6.7726044326484525 0.906810271196164 1.0154025370409023 0.33311894036472767 0.05852297679879488 0.1605465984134702 26.650773411001442 0.01545592274528584 0.02607580980880101 1.8284939771840965e-06 5.737906465831827 0.10859226584473836 SSS(ph)QGPLSSIR ddPTM_A459_Selumetinib_30min_R2 3 SSSQGPLSSIR 11 0 A0A0U1RQE4 A0A0U1RQE4 1 SS(0.016)S(0.984)QGPLSSIR;SS(0.001)S(0.999)QGPLSSIR;S(0.011)S(0.317)S(0.672)QGPLSSIR 147.52 0.00066503 44382000.0 125230.0 115439.0 124046.0 142807.0 136535.0 104216.0 102505.0 101673.0 78272.0 113392.0 True False 118270.21793540957 124292.80010511109 116065.01541107289 123356.44024418443 119382.25266161328 118570.80802134442 107271.68560980418 101968.85159712865 93928.58710240852 110118.07833220209 1.0740308923536994 1.128722930762985 1.0540050931594556 1.1202196960979023 1.084129458756656 1.0767605993235942 0.9741514493759057 0.9259955598708415 0.8529806233908893 1.0 16.748691813267953 -7.3773416972570205 2.179674000985686 0.9167461273341583 1.0937932637288725 0.7898599744072972 0.038811158828162606 0.1290494600498869 1.1973074270393305 0.019278732431274478 0.01139694489282858 4.194288529633654e-08 7.3773416972570205 0.17704713639471426 SSS(ph)QIPEGFGLTSGGSNYSLAR ddPTM_A459_Selumetinib_30min_R1 3 SSSQIPEGFGLTSGGSNYSLAR 22 0 A2RRE0;Q9Y4E6-2;Q9Y4E6 A2RRE0 WDR7 WD repeat-containing protein 7 1 S(0.012)S(0.017)S(0.971)QIPEGFGLTSGGSNYSLAR;S(0.019)S(0.019)S(0.962)QIPEGFGLTSGGSNYSLAR;S(0.014)S(0.014)S(0.461)QIPEGFGLT(0.388)S(0.107)GGS(0.008)NY(0.006)S(0.002)LAR 218.95 4.8595e-26 17657100.0 3737.5299999999997 4804.24 4464.37 4803.200000000001 4156.900000000001 4081.08 4326.05 4287.219999999999 2296.6099999999997 3218.46 True False 3824.6071770326043 4241.7573473694165 3858.1330750290604 3964.4112872307187 3780.909128960305 4040.0280405241633 3999.7325655771638 4173.508998746808 3897.1794322422056 3631.580691455196 1.0531521951395941 1.168019578182557 1.0623839597195026 1.0916489606188966 1.0411194050724155 1.1124709551490926 1.1013751050577503 1.1492265636742491 1.0731358500203345 1.0 11.826381920859134 -8.543528551170413 22.648938555683355 0.999999997910849 1.0980490802977374 0.37540165085889077 0.03782028406807434 1369.3437692343086 1501911.0022526886 0.03550226261312867 0.009166644866332962 2.860694288113422e-09 8.543528551170413 0.09804908238688836 SSS(ph)QIPEGFGLTSGGSNYSLAR ddPTM_A459_Selumetinib_30min_R2 2 SSSQIPEGFGLTSGGSNYSLAR 22 0 A2RRE0;Q9Y4E6-2;Q9Y4E6 A2RRE0 WDR7 WD repeat-containing protein 7 1 S(0.021)S(0.021)S(0.958)QIPEGFGLTSGGSNYSLAR;S(0.039)S(0.039)S(0.916)QIPEGFGLT(0.004)S(0.001)GGSNYSLAR 183.18 1.2757e-16 10771600.0 47436.0 44317.0 48298.0 56617.0 57941.0 63668.0 43778.0 55657.0 46624.0 56806.0 True False 44799.69702135347 47715.97139838538 45190.55926288634 48905.666930227366 50661.93358088789 72437.6890794402 45813.76374446132 55818.95265548763 55950.10278340515 55165.86318028681 0.8120909279520233 0.8649546775411717 0.8191761473068895 0.8865204695592167 0.9183565824995851 1.3130890174365182 0.8304730698174336 1.0118386523395178 1.0142160306738133 1.0 15.751488178163424 -6.532368905413084 24.99420961606347 1.0323670819368687 0.8523271166583005 0.38787953277754716 0.11198708881159103 223.0476745465629 587435.6133974452 0.03651110257282744 0.03655558142716947 2.9351553658019687e-07 6.532368905413084 -0.18003996527856814 SSS(ph)QLGSPDVSHLIR ddPTM_A459_Selumetinib_30min_R2 2 SSSQLGSPDVSHLIR 15 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 S(0.151)S(0.151)S(0.697)QLGSPDVSHLIR;S(0.295)S(0.295)S(0.41)QLGSPDVSHLIR 132.67 0.00039965 3957500.0 11521.900000000001 11129.7 13300.0 15146.5 10671.8 9707.8 8745.9 10084.0 8577.2 9888.599999999999 True False 10881.558923820152 11983.312202374029 12444.2924799451 13083.52057083012 9331.113076897516 11044.961331365688 9152.60167967207 10113.34277050393 10292.879666991732 9603.090424331665 1.1331309446227007 1.247859977660058 1.2958633033814393 1.362428134351414 0.9716781436583133 1.1501465510915847 0.953089190588253 1.053134181146459 1.0718299226790915 1.0 13.229283046992414 -6.266883653857857 24.992355182368502 1.0378001912513932 1.2615407417211426 0.6909184078813944 0.07417840435047329 261.13921953157376 1198777.3390660405 0.022865064096807015 0.026657290257110625 5.408992087546807e-07 6.266883653857857 0.2237405504697494 SSS(ph)QPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_A459_Selumetinib_30min_R2 1 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.028)S(0.033)S(0.396)QPS(0.396)S(0.072)CCS(0.072)DPS(0.004)KPGGNVEGATQSLAEQMR 91.265 2.7854e-07 92428000.0 71905.0 59334.0 76806.0 68276.0 75401.0 69243.0 61439.0 76165.0 55460.0 65067.0 True False 67908.80795852133 63884.72701111984 71864.38558005003 58976.69101733061 65928.45228650743 78780.59472462907 64296.03523906886 76386.62754020549 66553.5496818731 63188.346645631165 1.0747046182322693 1.011020708761286 1.1373044144211475 0.9333475893597898 1.04336409775434 1.2467582854547747 1.0175299505722117 1.2088720720703783 1.0532567034094824 1.0 15.947370897022399 -6.5656357961175855 24.999892742581277 1.1164319962913227 1.037135015895262 0.1171158860121555 0.087039313925407 248.46292133170968 145273.80876293423 0.02686540935316982 0.026865422194375935 2.718718258602369e-07 6.5656357961175855 -0.07929698039606081 SSS(ph)SASDGESEGKR ddPTM_A459_Selumetinib_30min_R1 1 SSSSASDGESEGKR 14 1 K7EJD2;A0A0A0MR03;Q9Y5B0;A0A0J9YWJ4;A0A0J9YWB6;Q9Y5B0-4 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 S(0.004)S(0.072)S(0.628)S(0.072)AS(0.152)DGES(0.072)EGKR 166.79 0.00040655 2430600.0 520.1 859.78 991.28 638.83 808.09 768.7 500.6 1171.2 887.62 499.3 True False 532.2173180615692 759.1165578991221 856.669620711278 527.2703328242841 734.9984021798776 760.967575923757 462.839338964628 1140.135971406241 1506.2263108001896 563.3900185938552 0.9446694128339569 1.3474086030025412 1.5205622968781178 0.9358886657954627 1.3045996164687717 1.3506941032129545 0.8215256282314195 2.0237063735205414 2.6735054954639157 1.0 9.137990193933598 -7.778185270242975 24.93783865728883 2.011455041625765 1.1975076493668313 0.35834297708249685 0.4355463291479387 225.75501648068166 336187.5343452722 0.22318243845825161 0.10767261550591958 1.6665361157450587e-08 7.778185270242975 -0.8139473922589335 SSS(ph)SDSIHSVR ddPTM_A459_Selumetinib_30min_R1 2 SSSSDSIHSVR 11 0 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 S(0.007)S(0.007)S(0.973)S(0.011)DS(0.002)IHSVR;S(0.002)S(0.049)S(0.893)S(0.055)DSIHSVR 170.4 0.00036539 14900240.0 4532.01 5666.040000000001 5107.070000000001 6124.28 7405.0599999999995 6205.66 5856.08 4933.42 1840.9 4125.2300000000005 True False 4637.597015243632 5002.657402729467 4413.55794512746 5054.789464973632 6735.273630469526 6143.236694688457 5414.351170842942 4802.569675593384 3123.872845983721 4654.743453642962 0.9963163515733804 1.0747439579756466 0.9481850050561343 1.0859437292978156 1.4469698915840936 1.3197798666821368 1.1631900285730001 1.0317581889147356 0.6711160082386218 1.0 12.184485940446928 -8.032556663698239 5.0441064311347 0.8346410562741566 1.1505978312947873 0.3838597279701751 0.15680306270820765 0.21649236836102925 14.135804575340527 0.11596775984748042 0.044821734617282165 9.277764324678255e-09 8.032556663698239 0.3159567750206307 SSS(ph)SDSIHSVR ddPTM_A459_Selumetinib_30min_R2 2 SSSSDSIHSVR 11 0 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 S(0.02)S(0.103)S(0.83)S(0.047)DSIHSVR;S(0.002)S(0.002)S(0.98)S(0.014)DS(0.001)IHSVR 148.78 0.00064275 55978800.0 74359.0 55074.2 71316.0 136335.0 146713.0 80368.0 81234.0 81974.0 67759.4 134146.0 True False 70226.42446266169 59298.2140485357 66727.60620298973 117765.93780900683 128281.60130913852 91437.96249193416 85011.54196211735 82212.53076847366 81313.17335582232 130272.85642683435 0.5390718096528667 0.45518472285774736 0.5122141943703078 0.9039944393569674 0.9847147351158745 0.7018957363791959 0.6525652717982945 0.631079512827348 0.6241758689116528 1.0 16.991176990593196 -5.7026554814751504 9.543036989301676 0.7692781188242677 0.4963237593274659 0.48098124903569084 0.13410882952157016 0.3567425061526069 54.680022515347524 0.03946697183613637 0.06833367560790514 1.9830995615944724e-06 5.7026554814751504 -0.27295435949680175 SSS(ph)SERPEPQQK ddPTM_A459_Selumetinib_30min_R1 2 SSSSERPEPQQK 12 1 P78362;C9J2M4 P78362 SRPK2 SRSF protein kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal 1 S(0.002)S(0.077)S(0.844)S(0.077)ERPEPQQK;SS(0.002)S(0.997)S(0.001)ERPEPQQK 193.11 0.00049426 21173000.0 5873.200000000001 6739.700000000001 6871.4 6766.0 6622.5 5982.1 5799.8 6284.5 3346.8999999999996 4560.8 True False 6010.034132742185 5950.612790798477 5938.301621898433 5584.445113549938 6023.4960442973415 5921.925505312223 5362.316416554233 6117.814645067041 5679.444852095668 5146.22310595405 1.167853396365332 1.1563068037049868 1.1539145310330539 1.085154102061544 1.1704692782029424 1.1507323688436097 1.0419906611414045 1.1887970107609374 1.103614191449394 1.0 12.329298288736569 -14.52287874527637 0.19982841993060846 0.38747439953269314 1.1569605487922845 0.5100616643819323 0.041360055869836605 117.47152302901154 1.1587745892429915 28.72055201723497 0.09771990346696918 3.0000000000274013e-15 14.52287874527637 0.7694861492595914 SSS(ph)SGSDDYAYTQALLLHQR ddPTM_A459_Selumetinib_30min_R1 2 SSSSGSDDYAYTQALLLHQR 20 0 F6SS63;Q8N5C8-2;Q8N5C8 F6SS63 TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 1 S(0.091)S(0.091)S(0.655)S(0.135)GS(0.028)DDYAYTQALLLHQR;S(0.222)S(0.222)S(0.333)S(0.069)GS(0.153)DDYAYTQALLLHQR 205.33 1.4154e-16 17759200.0 2228.3 2519.25 2683.3 2618.7 2571.6 2189.9 2345.8999999999996 2554.5 1227.02 1690.29 True False 2280.215054482974 2224.2950388324507 2318.9225983118513 2161.393204087086 2338.9992340528543 2167.8715942701097 2168.9468743050743 2486.7463618145844 2082.1633220049684 1907.2551863188614 1.1955479638170243 1.1662283341986863 1.21584285886124 1.1332480412643307 1.2263693137819116 1.136644749911131 1.1372085339515037 1.3038351551761578 1.0917067296189622 1.0 10.897282170476581 -8.522373306718261 24.99678985591634 0.9999999962012368 1.1861205831240607 0.6022965769565305 0.04947769583468689 28.153970861097086 1392344.9696395213 0.04509220006973275 0.011642755975720512 3.0034934783828596e-09 8.522373306718261 0.18612058692282385 SSS(ph)SGSDDYAYTQALLLHQR ddPTM_A459_Selumetinib_30min_R2 1 SSSSGSDDYAYTQALLLHQR 20 0 F6SS63;Q8N5C8-2;Q8N5C8 F6SS63 TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 1 S(0.093)S(0.093)S(0.637)S(0.135)GS(0.042)DDYAYTQALLLHQR 183.18 7.6711e-14 8493300.0 13779.0 7879.9 10512.0 12887.0 16060.0 6918.1 9384.8 9938.1 6660.0 10118.0 True False 13013.218341707337 8484.262992128011 9835.669364600219 11131.76836868503 14042.399221778356 7871.005478740908 9821.211795628406 9967.018225658978 7992.186095947975 9825.867050278875 1.3243837185175429 0.8634620180299726 1.0009976029872159 1.1329044359875693 1.429125709713303 0.8010494583801147 0.9995262245431727 1.014365264119475 0.81338227507578 1.0 13.262369003376403 -6.812070769850879 24.99999991701474 0.93117900604162 1.1250044419659326 0.31792193371847555 0.16224204095348804 157.26827030997 77652.34344135853 0.05855891750467887 0.05164418364265037 1.5414492477729246e-07 6.812070769850879 0.19382543592431267 SSS(ph)SGSLNAR ddPTM_A459_Selumetinib_30min_R2 1 SSSSGSLNAR 10 0 H0Y7V5;Q7Z3E2 H0Y7V5 CCDC186 Coiled-coil domain-containing protein 186 1 S(0.033)S(0.033)S(0.805)S(0.107)GS(0.022)LNAR 92.943 0.025915 3175800.0 9145.9 7719.4 11186.0 11670.0 11297.0 8180.7 8042.0 16151.0 10652.0 15936.0 True False 8637.60749193854 8311.453158216851 10466.304938395928 10080.525868127123 9877.769863538611 9307.51716799927 8415.968934920687 16197.996736058023 12782.697641747416 15475.886273299497 0.5581333010207615 0.5370582990491846 0.6762976125285577 0.6513698595420041 0.6382684447985832 0.6014206232606855 0.5438117589065471 1.046660362450736 0.825975160065719 1.0 13.917734411637214 -7.758081031320863 24.99978664794268 0.9522383550842018 0.6047497667640978 0.8528977275069549 0.06784908396521543 29.941815672909573 222894.5166222802 0.033000346992929495 0.018051800505389248 1.7454964451708954e-08 7.758081031320863 -0.3474885883201041 SSS(ph)SPELQTLQDILGDPGDKADVGR ddPTM_A459_Selumetinib_30min_R2 2 SSSSPELQTLQDILGDPGDKADVGR 25 1 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4;A0A2R8Y670 P49815 TSC2 Tuberin 1 S(0.133)S(0.133)S(0.586)S(0.147)PELQT(0.001)LQDILGDPGDKADVGR;S(0.051)S(0.051)S(0.765)S(0.133)PELQTLQDILGDPGDKADVGR 115.63 4.2897e-08 6598900.0 22020.8 22750.4 28659.4 31279.2 29903.7 20597.4 22672.4 23226.7 17447.6 25478.7 True False 20796.97209224682 24495.282525934217 26815.485405995398 27018.919000370355 26146.929863530077 23434.5048854191 23726.711524508293 23294.28585161282 20937.60752667596 24743.063729387293 0.8405172584810624 0.9899858317400368 1.0837576825276771 1.0919795258935552 1.056737764954928 0.9471141141501398 0.9589237526930878 0.941447110445997 0.8462010911691749 1.0 14.594736527945164 -6.870290173754891 6.3022933047131895 0.9348441531369576 1.0194753790271005 0.19225772796474172 0.07512736513434405 0.3573910911920423 18.60880659355293 0.02835210084832768 0.025027921067128436 1.3480618743999003e-07 6.870290173754891 0.08463122589014294 SSS(ph)SQTLTQFDSNIAPADPDTAIVHPVPIR ddPTM_A459_Selumetinib_30min_R2 1 SSSSQTLTQFDSNIAPADPDTAIVHPVPIR 30 0 Q96D71;Q96D71-3;H0YE73 Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 S(0.189)S(0.248)S(0.432)S(0.113)QT(0.018)LTQFDSNIAPADPDTAIVHPVPIR 186.19 1.2242999999999999e-39 4746800.0 2299.0 986.01 1241.5 1355.0 2619.7 2631.8 1021.0 783.66 774.61 1175.3 True False 2171.230783626182 1061.633796478146 1161.6232416429953 1170.4466624946233 2290.589865584852 2994.306560898268 1068.4785230731188 785.9403208581026 929.5536444117506 1141.3660352038712 1.9023089146317167 0.9301431475385691 1.0177482120672232 1.0254787915478472 2.006884553188676 2.623441094743479 0.9361401076581597 0.6885962054387904 0.814422030918165 1.0 10.156545821676405 -7.495082010302313 24.99525389062628 0.8133787322342054 1.5440771107263265 0.33622874068917086 0.49807909678583023 936.8825257341792 842461.7974812045 0.2319283807145085 0.15593859961638779 3.1982911011264695e-08 7.495082010302313 0.730698378492121 SSS(ph)SSASPSSPSSR ddPTM_A459_Selumetinib_30min_R2 1 SSSSSASPSSPSSR 14 0 E9PK91;Q9NYF8-3;H0YF63;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.154)S(0.154)S(0.584)S(0.097)S(0.011)AS(0.001)PSSPSSR 153.32 0.00036562 1559600.0 7330.7 5368.8 6548.3 6568.7 7710.7 5282.1 6683.5 5885.8 5551.1 7769.9 True False 6923.289041117203 5780.569696587122 6126.989507249964 5674.031728360463 6742.012931467391 6009.661328870263 6994.295993104007 5902.926703553354 6661.475110693216 7545.562798375356 0.91753116713943 0.7660886074438005 0.8119990080221946 0.7519693202450247 0.8935069671567802 0.7964497134878011 0.9269415920320692 0.7823043636750754 0.8828334331969918 1.0 12.881412795240978 -10.655093050192757 0.32407119037692556 1.0959106450153897 0.8160504546009737 0.41381052976401433 0.059997827045296805 15.19254713228836 1.1845218897879266 1.3472125866604823 0.054013334853148805 2.2126205916079977e-11 10.655093050192757 -0.279860190414416 SSS(ph)SSGVPY(ph)S(ph)PAIPNKR ddPTM_A459_Selumetinib_30min_R2 1 SSSSSGVPYSPAIPNKR 17 1 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-4;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 3 S(0.021)S(0.028)S(0.721)S(0.215)S(0.016)GVPY(1)S(0.999)PAIPNKR 99.711 0.004942899999999999 11020000.0 8666.1 12676.0 36061.0 74856.0 91564.0 33426.0 8640.0 17547.0 27016.0 53371.0 True False 8184.47285514696 13648.208440235869 33740.87452024814 64660.4836661974 80060.91172745406 38030.12808898305 9041.777119835213 17598.05886493778 32419.95489010968 51830.040555488675 0.15790982926947073 0.26332621572279585 0.6509907026625905 1.2475483903388536 1.54468163384402 0.7337468325587825 0.17445051215337531 0.33953395900004146 0.6255051036551135 1.0 15.661500902139117 -5.292726430654846 3.726034336390215 0.7920168333023507 0.19218042515159695 0.2774568033747321 0.37978064592422417 0.34083055295167886 10.233862152200615 0.11833236694678186 0.2990293828272843 5.096518081478926e-06 5.292726430654846 -0.5998364081507538 SSS(ph)TEPPPPVR ddPTM_A459_Selumetinib_30min_R1 3 SSSTEPPPPVR 11 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38;C9J286;C9J323;J3QT54 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 S(0.001)S(0.007)S(0.951)T(0.041)EPPPPVR;S(0.07)S(0.07)S(0.83)T(0.031)EPPPPVR;S(0.002)S(0.071)S(0.917)T(0.01)EPPPPVR 167.11 0.0005557 68544000.0 8697.4 9352.6 8601.1 9457.9 8957.4 7601.1 8671.1 8358.2 4923.2 7600.0 True False 8900.032497805601 8257.593244094223 7433.117862460429 7806.255311771202 8147.204751557419 7524.639835246606 8017.03194585734 8136.5133847401285 8354.310823698768 8575.534030268982 1.0378400302991324 0.9629246662595559 0.8667819212452336 0.910293782779887 0.9500521743369342 0.8774543729506472 0.9348726175605738 0.948805445354278 0.9742029819030087 1.0 13.06601080070918 -8.319764127586973 1.789927521231841 0.9985458423255751 0.9306034412118965 0.18247437062462624 0.045053186071979646 0.5826495832263346 3.6285193234643645 0.04447269871962736 0.01302277646816139 4.788901147332602e-09 8.319764127586973 -0.06794240111367855 SSS(ph)TEPPPPVR ddPTM_A459_Selumetinib_30min_R2 4 SSSTEPPPPVR 11 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;F5H6M0;F5H047;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38;C9J286;C9J323;J3QT54 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 S(0.001)S(0.272)S(0.718)T(0.009)EPPPPVR;SS(0.002)S(0.989)T(0.009)EPPPPVR;S(0.005)S(0.005)S(0.951)T(0.039)EPPPPVR;S(0.05)S(0.05)S(0.899)TEPPPPVR 231.07 2.7791e-07 96886000.0 124013.0 123014.0 130218.0 153633.0 145949.0 114542.0 119875.0 120700.0 116339.0 122724.0 True False 117120.85392337278 132448.77824764754 121839.91565063864 132707.92036829225 127613.58181938548 130319.12079124908 125449.42502780604 121051.21701703944 139610.0507832572 119180.63924475435 0.9827171146720274 1.1113279731252756 1.0223129899515229 1.1135023373700632 1.0707576551700893 1.0934588169444224 1.0525990280197932 1.01569531581756 1.1714155224201153 1.0 16.86279036515139 -4.7452865875991765 24.84268044725476 1.0725479680076382 0.9827168392828479 0.2256032460139581 0.04981300987825465 1287.2510958804637 1979651.613748858 0.011393129967761623 0.2949810904230182 1.797684245582707e-05 4.7452865875991765 -0.08983112872479027 SSS(ph)TGNLLDKDDLAIPPPDYGAASR ddPTM_A459_Selumetinib_30min_R1 1 SSSTGNLLDKDDLAIPPPDYGAASR 25 1 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 S(0.155)S(0.155)S(0.511)T(0.179)GNLLDKDDLAIPPPDYGAASR 62.398 0.0024676 28978000.0 4025.8 4951.1 5934.1 5259.7 4696.7 4637.8 4465.1 4225.2 2501.3 3678.1 True False 4119.593307156828 4371.4229102960535 5128.281813678066 4341.192131797013 4271.884314269735 4591.147942785478 4128.2939121273685 4113.133970616159 4244.523412276105 4150.219962727939 0.9926204741324168 1.053299090061414 1.2356650634746713 1.046014951203586 1.0293151574216386 1.106242074882151 0.9947168943339191 0.991064089989244 1.022722518419525 1.0 12.018972086357095 -7.270652945356151 24.429745927175762 1.001381209433208 1.079716576945702 0.2639967132634663 0.061311880488712535 708.8187191117377 1879421.1677011086 0.02664975710289861 0.018266077524212904 5.3622499598971996e-08 7.270652945356151 0.07833536751249404 SSS(ph)TGNLLDKDDLAIPPPDYGAASR ddPTM_A459_Selumetinib_30min_R2 1 SSSTGNLLDKDDLAIPPPDYGAASR 25 1 B4DWA1;I3L4C2;Q9UQB8-3;Q9UQB8-5;Q9UQB8-4;Q9UQB8-2;Q9UQB8;I3L3C6;Q9UQB8-6 B4DWA1 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 1 S(0.134)S(0.134)S(0.441)T(0.291)GNLLDKDDLAIPPPDYGAASR 49.087 0.023889 14173000.0 23815.0 22568.0 22391.0 21607.0 24689.0 22368.0 21009.0 24724.0 16216.0 23091.0 True False 22491.45763899849 24298.893032442662 20950.3874374775 18664.089325845987 21587.347097539583 25448.988963512602 21985.960128543742 24795.94274672145 19459.653112896736 22424.302832376914 1.0029947333089266 1.0835963648046687 0.9342715175621278 0.8323152548090899 0.9626763988564716 1.1348842884323054 0.9804523374880454 1.1057620355947158 0.8677930037940924 1.0 14.452775512256643 -6.583208730147943 24.999997664049754 1.0250250653469564 0.960771222870155 0.0822288936018657 0.08943960065589288 177.2731162546667 73457.99410592398 0.03025940877108193 0.030259410789300896 2.6109062018608063e-07 6.583208730147943 -0.06425384247680133 SSS(ph)TGSSSSTGGGGQESQPSPLALLAATCSR ddPTM_A459_Selumetinib_30min_R2 1 SSSTGSSSSTGGGGQESQPSPLALLAATCSR 31 0 P08047;H3BVI2;P08047-2 P08047 SP1 Transcription factor Sp1 1 S(0.169)S(0.169)S(0.526)T(0.055)GS(0.065)S(0.007)S(0.007)S(0.001)TGGGGQESQPSPLALLAATCSR 100.33 1.6674e-08 1681400.0 1028.1 619.38 0.0 792.41 796.9 0.0 615.56 0.0 685.85 573.75 True False 970.9623178103865 666.8844543794017 0.0 684.4823910165053 696.786297623609 0.0 644.1847597089996 0.0 823.039164250138 557.1843467184731 1.7426231076462415 1.1968829675618229 0.0 1.228466655690799 1.2505489461922594 0.0 1.156142959691732 0.0 1.4771397816493086 1.0 9.122010917870304 -5.000736648860296 7.416483036054931 0.73878445046457 1.617731988941119 0.2390736647752063 0.5424735498844145 0.1430508297942561 61.03624075085745 0.12826768921641224 0.43265403225275445 9.983052410441026e-06 5.000736648860296 0.878947538476549 SSS(ph)TSDILEPFTVER ddPTM_A459_Selumetinib_30min_R1 4 SSSTSDILEPFTVER 15 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 SS(0.002)S(0.992)T(0.006)SDILEPFTVER;S(0.003)S(0.003)S(0.938)T(0.053)S(0.003)DILEPFTVER;SS(0.001)S(0.992)T(0.006)S(0.001)DILEPFTVER;SSS(0.999)T(0.001)SDILEPFTVER 360.06 3.711499999999997e-189 185974000.0 12389.699999999999 14042.8 14607.599999999999 16721.600000000002 14018.6 13145.400000000001 14037.4 12564.0 7115.799999999999 10570.4 True False 12678.355903840467 12398.66244767939 12623.96815380323 13801.486463307216 12750.620105184855 13013.169211068236 12978.547616424426 12230.761906376372 12074.992882530805 11927.213804415158 1.0629771639665968 1.0395271394472456 1.0584171928845738 1.1571425388717564 1.0690359302911878 1.0910485402928791 1.0881458007921423 1.0254500428129198 1.0123900753804667 1.0 13.541969448566729 -7.856130687219168 4.035623617215547 1.0097967465025655 1.081366929949587 0.5308128286545463 0.029671024619104612 0.19335046167519412 5.779725077088761 0.018845171748212656 0.008556832763312278 1.3927376394398998e-08 7.856130687219168 0.07157018344702148 SSS(ph)TSDILEPFTVER ddPTM_A459_Selumetinib_30min_R2 4 SSSTSDILEPFTVER 15 0 A0A1B0GUI1;Q6GYQ0-3;Q6GYQ0-4;Q6GYQ0;Q6GYQ0-7;Q6GYQ0-5;Q6GYQ0-6;Q6GYQ0-2 A0A1B0GUI1 RALGAPA1 Ral GTPase-activating protein subunit alpha-1 1 S(0.02)S(0.004)S(0.971)T(0.005)SDILEPFTVER;SS(0.007)S(0.99)T(0.002)SDILEPFTVER;SSS(0.995)T(0.005)SDILEPFTVER;SS(0.002)S(0.993)T(0.004)SDILEPFTVER 230.57 6.667899999999999e-14 33264200.0 74629.0 66468.9 79773.0 84163.0 88108.0 65175.4 70121.0 69369.6 58661.0 74891.9 True False 70481.41894355736 71566.85089880059 74640.49203027535 72699.8542107269 77039.08534448607 74152.71974662547 73381.76544212553 69571.45405124458 70394.83912528591 72729.57625447537 0.9690888160402328 0.9840130327226645 1.0262742597195098 0.9995913348423141 1.059253873210151 1.0195676032426015 1.0089673173038738 0.9565771950577472 0.9678983812442358 1.0 16.150254550275854 -1.5254640208058308 24.88205972664532 1.0007761126736254 0.006524719810431456 0.0 0.02968434122624961 0.0 0.0 0.007418855948195856 0.0 0.02982194598069155 1.5254640208058308 -0.994251392863194 SSS(ph)VGS(ph)SSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R1 1 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.044)S(0.065)S(0.891)VGS(0.522)S(0.347)S(0.083)S(0.048)YPISPAVSR 192.24 4.536e-09 25223000.0 2864.3 3964.0 4088.2 4339.9 4298.1 3711.7 3868.2 3524.3 1630.9 2537.3 True False 2931.032617042403 3499.8930371863953 3533.0448948751587 3582.0179350126186 3909.337613891188 3674.3636679539554 3576.418559694311 3430.824115460221 2767.518183776877 2862.9871703949307 1.0237672901056298 1.2224620052012345 1.2340414694865007 1.251147043917246 1.3654750724404818 1.283402072474918 1.2491912631243007 1.1983372300571506 0.9666540641169257 1.0 11.483305490015391 -8.200989110067102 4.128562261044452 0.9804131899899664 1.2390309488048448 0.5938156295882875 0.08119947298651171 0.1505383554993154 5.023954315845196 0.06723522994953281 0.022088702487285446 6.29521967920846e-09 8.200989110067102 0.25861775881487836 SSS(ph)VGS(ph)SSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R2 2 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.158)S(0.008)S(0.834)VGS(0.53)S(0.346)S(0.062)S(0.062)YPISPAVSR;S(0.017)S(0.008)S(0.975)VGS(0.764)S(0.181)S(0.044)S(0.011)YPISPAVSR 193.27 4.739899999999999e-09 48496000.0 132377.0 115524.0 127613.0 139611.0 137897.0 112259.0 95130.0 106072.0 91603.0 122216.0 True False 125020.01628711737 124384.319331793 119402.51851452915 120595.74095759174 120573.14604517879 127721.65826425984 99553.73349651879 106380.6519588352 109926.15960166982 118687.30652469685 1.0533562513789356 1.048000186152263 1.0060260192161616 1.0160795159042368 1.015889142450878 1.0761189381080367 0.8387900645112654 0.8963102717028898 0.9261829493012887 1.0 16.856806123038332 -7.254462057598151 24.9713623643669 0.9066800096567229 1.0332911386833805 0.6625697381205331 0.04195379717580593 309.87318225049336 1109017.8452407478 0.015851241918236267 0.011997835515634625 5.565932592431486e-08 7.254462057598151 0.1266111290266576 SSS(ph)VGSS(ph)SSYPISPAVSR ddPTM_A459_Selumetinib_30min_R1 2 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.204)S(0.274)S(0.522)VGS(0.34)S(0.477)S(0.091)S(0.091)YPISPAVSR;S(0.166)S(0.228)S(0.606)VGS(0.108)S(0.635)S(0.148)S(0.108)YPISPAVSR 133.9 0.0075118 28062300.0 7633.6 9974.2 9593.8 9678.9 9989.3 8855.6 9036.7 8731.9 4763.54 7616.1 True False 7811.4480276000695 8806.416027120225 8291.014654971206 7988.661810454989 9085.76957875416 8766.520704241468 8355.054443511088 8500.301646791457 8083.379464803784 8593.70062209626 0.9089737205314263 1.0247524802617662 0.9647781578116903 0.9295950792042272 1.057259262138209 1.0201100887434746 0.9722301032954812 0.9891316931538604 0.9406168332207978 1.0 13.069063803624042 -2.2543849619232295 9.237314792154953 0.9827830000063044 0.9341159127175553 0.0 0.04419104172769093 0.0 0.0 0.009947332527111163 0.0 0.005566920740882651 2.2543849619232295 -0.04866708728874902 SSS(ph)VGSSSSYPIS(ph)PAVSR ddPTM_A459_Selumetinib_30min_R1 1 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.131)S(0.195)S(0.674)VGSSSS(0.005)YPIS(0.995)PAVSR 199.09 3.5752e-09 42666000.0 4797.6 4998.2 6108.4 5910.2 5597.8 4441.4 5624.8 4973.2 3177.8 4292.8 True False 4909.3747454954555 4413.008420399859 5278.912831039435 4878.094518194328 5091.479978371863 4396.723548468548 5200.516807447542 4841.294580769735 5392.494502671015 4843.822695412981 1.0135331233623706 0.9110590328954243 1.0898237121764338 1.0070753669026329 1.051128478173532 0.9076970452762797 1.0736389695626853 0.9994780744874001 1.1132724795599178 1.0 12.241930341864027 SSS(ph)VGSSSSYPIS(ph)PAVSR ddPTM_A459_Selumetinib_30min_R2 3 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 2 S(0.003)S(0.004)S(0.993)VGS(0.001)SS(0.001)S(0.001)YPIS(0.997)PAVS(0.001)R;S(0.186)S(0.28)S(0.424)VGS(0.108)S(0.002)S(0.005)S(0.01)YPIS(0.984)PAVSR;S(0.007)S(0.01)S(0.983)VGSSSSYPIS(1)PAVSR 206.8 3.4692000000000003e-10 115148300.0 275953.0 251125.0 271433.0 314846.0 338884.0 216641.0 234858.0 253063.0 213443.0 288161.0 True False 260616.63698738394 270385.4800058558 253969.29629390573 271963.4316603551 296310.36225860094 246481.3312788062 245779.3623622985 253799.37143316495 256137.56409570982 279841.0431978067 0.9313024065707406 0.9662109493164404 0.9075484188871701 0.9718496920700683 1.0588524073259435 0.8807904961409823 0.8782820402387095 0.9069411996644321 0.9152966311473404 1.0 18.09424804693043 SSS(ph)VGSSSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R1 10 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(0.071)S(0.071)S(0.857)VGSSSSYPISPAVSR;S(0.063)S(0.063)S(0.864)VGS(0.009)S(0.001)SSYPISPAVSR;SSS(0.998)VGS(0.002)SSSYPISPAVSR;S(0.057)S(0.057)S(0.884)VGS(0.001)SSSYPISPAVSR;S(0.065)S(0.065)S(0.868)VGS(0.001)SSSYPISPAVSR;S(0.01)SS(0.962)VGS(0.027)SSSYPISPAVSR;SS(0.005)S(0.995)VGSSSSYPISPAVSR;S(0.006)S(0.006)S(0.987)VGSSSSYPISPAVSR;SS(0.009)S(0.988)VGS(0.003)SSSYPISPAVSR;S(0.067)S(0.067)S(0.777)VGS(0.067)S(0.02)S(0.001)SYPISPAVSR 371.87 3.032599999999997e-230 7967734000.0 25769.370000000003 35895.59999999999 30467.999999999993 34899.3 28815.5 27524.8 26736.0 24800.52 14709.000000000002 21662.3 True False 26369.746182534655 31692.926464588272 26330.61294874427 28804.792395996654 26209.143112789712 27247.925502518803 24719.281994722904 24142.7296461577 24960.098697145193 24442.867213670495 1.0788319533882869 1.2966124713414529 1.077230945067606 1.1784539082177155 1.0722614038557379 1.1147597891985226 1.0113086070728157 0.9877208526770159 1.021160835140708 1.0 14.577125906617793 -6.846777584079224 0.8448342574137482 0.9933266617125635 1.1716378322554704 0.5308936952432073 0.061581401132256554 0.44067221388683137 0.6763465485749588 0.03899547495615951 0.03364583975354062 1.4230573931721607e-07 6.846777584079224 0.1783111705429069 SSS(ph)VGSSSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R2 8 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 S(0.001)S(0.002)S(0.997)VGSSSSYPISPAVSR;S(0.144)S(0.144)S(0.712)VGSSSSYPISPAVSR;SSS(1)VGSSSSYPISPAVSR;SS(0.005)S(0.995)VGSSSSYPISPAVSR;S(0.24)S(0.019)S(0.733)VGS(0.008)S(0.001)SSYPISPAVSR;SS(0.002)S(0.997)VGS(0.001)SSSYPISPAVSR;S(0.001)S(0.01)S(0.985)VGS(0.002)S(0.002)S(0.001)SYPISPAVSR;S(0.007)S(0.151)S(0.842)VGSSSSYPISPAVSR 308.29 2.3366999999999988e-111 4793725300.0 1184166.6 1135614.1 1160404.0 1292903.8 1340577.8 1219946.0 1028551.3 988451.4 943330.2 1227912.0 True False 1118355.3609664862 1222712.049895144 1085744.8699923495 1116808.072056541 1172162.4318464082 1387982.4879328224 1076380.973485737 991327.6299270628 1132022.5988480188 1192458.99006148 0.9378564548444779 1.0253703146907418 0.910509190707155 0.9365588933158709 0.9829792400541796 1.1639666432983675 0.9026565965427806 0.8313305851096418 0.9493178451274493 1.0 20.185508220584488 SSS(ph)VLSLEGSEK ddPTM_A459_Selumetinib_30min_R1 1 SSSVLSLEGSEK 12 0 A1L390-3;A1L390;G3V311;A1L390-2;A0A0U1RR71 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.092)S(0.092)S(0.816)VLSLEGSEK 104.17 0.010019 12686000.0 3299.1 4176.6 3946.5 3861.3 2999.1 3571.3 3370.8 3331.0 1720.0 3089.3 True False 3375.962611068878 3687.60173035134 3410.5869765727753 3186.996440577943 2727.8319345341097 3535.375964480955 3116.53784215335 3242.651059387111 2918.71437617035 3485.841747330259 0.9684784496182205 1.0578798458580643 0.9784113060166544 0.9142688256054091 0.7825461200650619 1.014210116448526 0.8940560323888048 0.9302347307850671 0.8373054738947168 1.0 11.767291359138806 -5.662530242828515 3.696259514137909 0.9055756193122164 1.0138867907472182 0.2841709193453251 0.06739086931448383 0.2637098394529338 6.862111464717836 0.01821164131891932 0.033062725457213483 2.1750525652929353e-06 5.662530242828515 0.1083111714350018 SSS(ph)VLSLEGSEK ddPTM_A459_Selumetinib_30min_R2 2 SSSVLSLEGSEK 12 0 A1L390-3;A1L390;G3V311;A1L390-2;A0A0U1RR71 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.003)S(0.047)S(0.948)VLS(0.002)LEGSEK;S(0.046)S(0.046)S(0.906)VLS(0.001)LEGSEK 91.307 0.023218 14011600.0 139160.0 139865.0 148861.0 151801.0 169125.0 113458.0 131175.0 126665.0 118484.0 142527.0 True False 131426.04430161804 150592.19576314194 139283.44532760218 131125.4419286688 147878.0055033166 129085.80963082152 137274.8974183313 127033.5741794804 142184.1107195642 138411.8751803815 0.9495286739691998 1.0880005459566728 1.0062969318642987 0.9473568778530248 1.068391027219295 0.9326209146620834 0.9917855475870949 0.9177938960362134 1.0272536986748184 1.0 17.07860820013461 -6.778105304124986 24.998680355592494 0.9698713666504951 1.0122431612281098 0.12024315052362367 0.050843708049730374 483.0132698566506 724510.1734694607 0.01708201696858454 0.015108332732006458 1.6668430012779516e-07 6.778105304124986 0.04237179457761464 SSS(ph)VPHPFQVTLLR ddPTM_A459_Selumetinib_30min_R2 1 SSSVPHPFQVTLLR 14 0 Q5VV41;Q5VV41-2 Q5VV41 ARHGEF16 Rho guanine nucleotide exchange factor 16 1 S(0.048)S(0.148)S(0.804)VPHPFQVTLLR 96.135 0.012009 4299800.0 10880.0 12834.0 14015.0 17948.0 19280.0 16153.0 10725.0 15098.0 10299.0 17933.0 True False 10275.333156090855 13818.326532185807 13113.29015837824 15503.45143797306 16857.87403461312 18377.929127665386 11223.733751184329 15141.932680391545 12359.087778103323 17415.22769447037 0.5900200293880423 0.7934622948727429 0.7529783927282175 0.8902238724616658 0.9679961887587483 1.0552792906348671 0.644478151425379 0.8694650995116971 0.7096713287318973 1.0 14.088061715037151 -4.355474255856483 1.089810289105259 0.8667645938062305 0.18517141350418617 0.321936719716704 0.12145851900361444 4.939101434414719 2.582321935042453 0.038740357152001276 4.852964901670981 4.410885092269037e-05 4.355474255856483 -0.6815931803020443 SSS(ph)YSEANEPDLQMANGGK ddPTM_A459_Selumetinib_30min_R1 1 SSSYSEANEPDLQMANGGK 19 0 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 S(0.175)S(0.175)S(0.611)Y(0.001)S(0.039)EANEPDLQMANGGK 139.29 0.0001456 0.0 386.88 328.32 417.3 385.98 458.47 401.3 412.06 482.9 121.32 300.87 True False 395.89355126256476 289.8801417681731 360.6329520648217 318.5758387419456 417.0014694494528 397.26328635124685 380.97798244859064 470.09192331973475 205.8711791377831 339.48959522197754 1.166143401254189 0.8538704745240661 1.0622798375573763 0.9383964728982125 1.2283188507641702 1.17017809070553 1.1222081259942167 1.384702005410098 0.606413810718331 1.0 8.40722354877586 -4.456663827228989 21.925312242966125 1.0595646948845163 4.182458420729443 0.025656078564727403 0.2040207483706845 1572.1652500820094 549327.6943197843 0.04732963235502971 13219.52553544869 3.494106778953271e-05 4.456663827228989 3.1228937258449267 SSSALDS(ph)PAGPR ddPTM_A459_Selumetinib_30min_R1 1 SSSALDSPAGPR 12 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 SSS(0.04)ALDS(0.96)PAGPR 141.34 0.00099971 19707000.0 3269.4 3491.2 3855.0 3818.1 3575.1 3107.8 3273.9 3072.1 1768.6 2779.9 True False 3345.5706588550174 3082.448680985153 3331.512173999251 3151.3405096135084 3251.7328362351714 3076.538353656628 3026.9470871679896 2990.6179284128334 3001.1850265667913 3136.727243519043 1.0665800368098555 0.9826957977790265 1.0620981409469579 1.00465876213007 1.0366641992713097 0.9808115640316593 0.9650016887576451 0.9534198214371066 0.9567886505808554 1.0 11.615044368663275 -6.872383415185544 3.9680204372561447 0.9657379099700935 1.0282443503749923 0.5653345410664552 0.02602064086403765 0.15855344680574965 4.6170759903600285 0.008853068232913517 0.007799664467356941 1.3415800294743535e-07 6.872383415185544 0.06250644040489883 SSSALDS(ph)PAGPR ddPTM_A459_Selumetinib_30min_R2 2 SSSALDSPAGPR 12 0 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 SSS(0.004)ALDS(0.996)PAGPR;SSS(0.001)ALDS(0.999)PAGPR 167.22 0.00043822 34442000.0 94015.0 84011.0 90728.0 109110.0 115318.0 88875.0 71079.0 86635.0 66493.0 91047.0 True False 88790.02267186412 90454.37356205856 84890.65925717738 94249.02977475176 100830.72188399974 101116.72452307679 74384.31434036653 86887.0935068037 79793.45796964983 88418.23654148458 1.0042048580125786 1.023028473539151 0.960103510064328 1.0659455951774321 1.1403837695483938 1.1436184262240319 0.8412779676449039 0.9826829498690297 0.9024547547067608 1.0 16.43205634028086 -7.261475757420477 24.99999999995813 0.9301608332457091 1.054605237128629 0.4573895022367658 0.06646928631380597 3.35113540607293 2301653.5412160093 0.028430668408173033 0.02059560430195951 5.476766717502877e-08 7.261475757420477 0.12444440388291989 SSSAS(ph)SPEMK ddPTM_A459_Selumetinib_30min_R1 2 SSSASSPEMK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSS(0.003)AS(0.499)S(0.499)PEMK;SSSAS(0.5)S(0.5)PEMK 180.66 0.00012575 57075000.0 12037.8 13783.2 13533.599999999999 13155.5 12329.7 12368.099999999999 11018.0 12181.2 8653.4 10668.0 True False 12318.25731851867 12169.456536364154 11695.811454743523 10858.138884319558 11214.480811985344 12243.688143336301 10186.90338935731 11858.11500588601 14684.187780670063 12037.34171511966 1.0233370132747965 1.010975415035244 0.9716274349886442 0.9020379367216144 0.9316409783315571 1.0171421924458168 0.8462751685915767 0.985110773335567 1.2198862612852301 1.0 13.555229207041794 -8.063058628184844 10.11636056280805 1.1079859971999184 0.9562298916586446 0.4134039623787972 0.07159818891033891 0.5815428129868537 90.74734405408343 0.0466072280151647 0.017621167558288034 8.648511591152349e-09 8.063058628184844 -0.15175610554127383 SSSAS(ph)SPEMK ddPTM_A459_Selumetinib_30min_R2 2 SSSASSPEMK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSSAS(0.923)S(0.077)PEMK;S(0.014)S(0.001)S(0.208)AS(0.493)S(0.283)PEMK 163.46 0.00039167 115215000.0 883780.0 814160.0 722740.0 879040.0 887760.0 706110.0 1192570.0 1356630.0 835150.0 1267780.0 True False 834663.0456516516 876603.4540629868 676239.6952598124 759313.23557142 776231.6521249041 803370.243071616 1248026.8680326235 1360577.5686978125 1002203.336040682 1231175.897311977 0.6779397220770558 0.7120050481632012 0.5492632667161895 0.6167382233759015 0.6304798963492125 0.6525227181799221 1.0136868913348913 1.105104129855334 0.8140212444288341 1.0 20.2316054627884 -7.253466030947525 11.422682559664816 0.9919976609165663 0.6374680817744275 0.823250321798698 0.07789847513360552 0.16742881419320088 236.24873819989304 0.030284769007389745 0.02251638090475016 5.578712352449051e-08 7.253466030947525 -0.3545295791421388 SSSASS(ph)PEMK ddPTM_A459_Selumetinib_30min_R1 2 SSSASSPEMK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSSAS(0.001)S(0.999)PEMK;SSSAS(0.017)S(0.983)PEMK 136.96 0.006823399999999999 20462700.0 14714.2 17960.4 17667.7 16743.6 15040.4 16232.9 14221.2 14673.599999999999 10976.9 14118.5 True False 15057.012231150837 15857.588018436569 15268.523381729334 13819.644576298355 13679.99847559829 16069.611764293932 13148.483434446198 14284.408461429826 18626.99757894437 15930.74700083587 0.9451541870799159 0.995407686632933 0.9584311006212207 0.8674825214142973 0.8587166989018477 1.008716776649003 0.8253525985791068 0.8966565384963013 1.1692482203105121 1.0 13.959526296703585 -8.247755554591263 24.990069147997758 1.0846241133393613 0.9193953852732923 0.48676274376317885 0.06782619092596176 565.8740656040638 1033431.9447723252 0.04629126161804702 0.017298195480256618 5.652550426831665e-09 8.247755554591263 -0.16522872806606892 SSSASS(ph)PEMK ddPTM_A459_Selumetinib_30min_R2 2 SSSASSPEMK 10 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSSAS(0.343)S(0.656)PEMK;SSSAS(0.01)S(0.99)PEMK 144.7 0.00095209 10300400.0 124464.0 109101.0 98384.0 126066.0 124767.0 103816.0 152264.0 180627.0 116263.0 182806.0 True False 117546.78914886877 117468.69588499336 92054.08055239977 108895.59332401984 109092.65402886784 118115.71165218274 159344.5777053923 181152.59466559062 139518.84865963974 177527.91579297112 0.6621312970628748 0.6616914041957356 0.5185329875654658 0.6133998297541629 0.614509856332055 0.6653359902559015 0.8975747672902114 1.0204175149380252 0.7858980827688156 1.0 17.437686376853726 -7.236636574363184 3.2511994719597577 0.9339975015398239 0.6132991384273978 0.8244549157100632 0.06905030289955177 0.09857387881550135 2.154257133667405 0.02913409525760032 0.020505947745248262 5.7991377598613587e-08 7.236636574363184 -0.32069836311242605 SSSCGSGGGGIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SSSCGSGGGGISPK 14 0 F5GWH4;Q96EP1-2;Q96EP1-4;Q96EP1;F5H375 F5GWH4 CHFR E3 ubiquitin-protein ligase CHFR 1 SSSCGS(0.002)GGGGIS(0.998)PK;SSSCGSGGGGIS(1)PK 85.90899999999998 0.024002 11098900.0 50874.0 52377.0 42998.0 55171.0 46505.0 37788.0 45393.0 51603.0 31532.0 51777.0 True False 48046.62674475788 56394.14748140061 40231.55549268266 47656.61462471649 40662.62614002505 42992.95399468948 47503.86444452308 51753.15618666346 37839.28107769243 50282.06347719801 0.9555420645484476 1.1215559502042773 0.8001174317543059 0.9477855785757059 0.8086904818149478 0.8550355936403842 0.9447477123938084 1.0292568086457423 0.7525403386607602 1.0 15.617756235895683 -5.259114476032355 24.998910838251295 0.8928585008884246 1.0385490036238805 0.2838256053199495 0.0929400417912144 245.14530618161342 2635925.054603801 0.0229339180819821 0.05490545428601587 5.506625276943832e-06 5.259114476032355 0.14569050273545592 SSSERS(ph)TPPYLFPEYPEASK ddPTM_A459_Selumetinib_30min_R1 2 SSSERSTPPYLFPEYPEASK 20 1 Q8TE76-2;Q8TE76-3;Q8TE76 Q8TE76-2 MORC4 MORC family CW-type zinc finger protein 4 1 S(0.078)S(0.078)S(0.078)ERS(0.394)T(0.36)PPY(0.013)LFPEYPEASK;S(0.112)S(0.112)S(0.112)ERS(0.571)T(0.093)PPYLFPEYPEASK 106.93 0.0002531 28321000.0 2812.92 3197.3999999999996 5241.4 6491.200000000001 4757.8 4419.1 3693.8999999999996 3190.8 1907.08 2329.08 True False 2878.455563010479 2823.0469215690664 4529.646668949329 5357.633774915065 4327.457830057812 4374.64786622177 3415.266149024048 3106.1696188208957 3236.1754723877625 2628.0401051603785 1.0952860108026468 1.074202374623498 1.723583540469944 2.038642319192504 1.6466483222841553 1.6646046830228274 1.2995487178136607 1.1819338725926098 1.2314026205434456 1.0 11.359771576712934 -7.474968154211267 3.562135433049223 1.1610095896665675 1.554245549884411 0.303077636104107 0.2754003110992884 0.3576764484185089 9.210939857513239 0.14947888770858192 0.0906368094759741 3.349900022829972e-08 7.474968154211267 0.39323596021784346 SSSET(ph)ILSSLAGSDIVK ddPTM_A459_Selumetinib_30min_R2 1 SSSETILSSLAGSDIVK 17 0 Q01850 Q01850 CDR2 Cerebellar degeneration-related protein 2 1 S(0.067)S(0.067)S(0.316)ET(0.55)ILSSLAGSDIVK 119.47 0.0035173 7153400.0 31547.0 30579.0 32321.0 31178.0 38542.0 28968.0 28578.0 33236.0 28105.0 34404.0 True False 29793.74403264686 32924.310973017746 30241.502048444032 26931.502614950066 33700.00939014828 32958.07905467783 29906.933626232712 33332.71125748402 33726.78531931199 33410.66712767293 0.891743463810386 0.9854430875984409 0.905145112274517 0.8060749733621334 1.0086601761458303 0.986453785215793 0.8951312918101478 0.9976667370965382 1.009461594718569 1.0 15.028021169530813 -6.31435007224614 24.999988162604712 0.9785686363311289 0.9039857441306802 0.39967153617002515 0.051069507101196676 404.7992195792542 191264.17238007765 0.01661240158655882 0.018836701312782318 4.848974807256957e-07 6.31435007224614 -0.07458289220044867 SSSFS(ph)LPSR ddPTM_A459_Selumetinib_30min_R2 1 SSSFSLPSR 9 0 Q14153-2;Q14153 Q14153-2 FAM53B Protein FAM53B 1 SSS(0.071)FS(0.929)LPSR 130.41 0.0038495 8747800.0 42839.0 31906.0 38998.0 43961.0 35679.0 28441.0 41068.0 35710.0 32713.0 34056.0 True False 40458.17987810438 34353.0876060402 36488.91113781197 37973.43596304513 31196.685045693026 32358.489588307508 42977.74337469819 35813.91018789126 39256.5140775895 33072.714791885526 1.2233099137065973 1.0387138710024741 1.1032934963888907 1.1481801902867075 0.943275604739506 0.9784043974595864 1.2994924560968575 1.0828838942691905 1.1869758598475013 1.0 15.013353854350841 -10.289895756705011 13.888033698484815 0.9999998114473636 1.1061127341657395 0.09247754419230259 0.10361220755796521 0.0 0.0 0.10123859769403723 0.02455396656952518 5.129845004009469e-11 10.289895756705011 0.10611292271837591 SSSGES(ph)LAQSPDSSK ddPTM_A459_Selumetinib_30min_R1 1 SSSGESLAQSPDSSK 15 0 Q9H7U1-3;Q9H7U1-2;Q9H7U1 Q9H7U1-3 CCSER2 Serine-rich coiled-coil domain-containing protein 2 1 SSSGES(0.515)LAQS(0.136)PDS(0.307)S(0.042)K 148.18 0.00030965 12144000.0 5362.0 6157.9 6369.6 6673.4 5365.3 5219.2 5834.4 5477.3 3184.9 4617.8 True False 5486.924167364227 5436.930205269954 5504.643305708334 5508.015965232655 4880.0095623206535 5166.699586654442 5394.306510697611 5332.024211222166 5404.542684107534 5210.539611181065 1.0530433653340012 1.0434485890104526 1.05644399936931 1.0570912758082192 0.9365651019807734 0.9915862793879259 1.035268304864665 1.0233151667785831 1.0372328179811101 1.0 12.347217072532958 SSSGESLAQS(ph)PDSSK ddPTM_A459_Selumetinib_30min_R1 1 SSSGESLAQSPDSSK 15 0 Q9H7U1-3;Q9H7U1-2;Q9H7U1 Q9H7U1-3 CCSER2 Serine-rich coiled-coil domain-containing protein 2 1 S(0.001)S(0.001)S(0.005)GES(0.015)LAQS(0.586)PDS(0.061)S(0.332)K 107.63 0.0041905 12246000.0 2147.5 2970.6 2622.4 2633.5 2326.6 2506.1 2599.9 2231.4 1416.9 1772.4 True False 2197.532571692407 2622.8007710055276 2266.2924838120975 2173.608661917494 2116.159440794591 2480.8909093567395 2403.7874498085016 2172.2160233912937 2404.3758137184705 1999.904804637993 1.0988185870627913 1.3114628080911512 1.1332001796067108 1.0868560627869202 1.0581300849355384 1.2405044998158354 1.201950934981436 1.0861597103790603 1.2022451309394657 1.0 10.965715614089453 -11.948702523974745 1.8810488539764236 2.229529993461328e-05 1.158124978865375 0.27650888817366137 0.07652577309977439 2034846.5665325492 133190.43077954062 8685199.548511269 0.019461069904787527 1.1253755516110946e-12 11.948702523974745 1.1581026835654402 SSSGESLAQS(ph)PDSSK ddPTM_A459_Selumetinib_30min_R2 2 SSSGESLAQSPDSSK 15 0 Q9H7U1-3;Q9H7U1-2;Q9H7U1 Q9H7U1-3 CCSER2 Serine-rich coiled-coil domain-containing protein 2 1 SSSGES(0.211)LAQS(0.77)PDS(0.019)SK;S(0.002)SS(0.007)GES(0.08)LAQS(0.717)PDS(0.189)S(0.005)K 205.12 4.2748e-06 20115200.0 114285.0 120734.0 123637.0 119924.0 129861.0 100038.0 107160.0 105464.0 96028.0 119403.0 True False 107933.49721910307 129993.90957900243 115682.33002578748 103590.14431956086 113546.70020793023 113817.32644545214 112143.1523335116 105770.88277949479 115236.28324650004 115955.52514374872 0.9308180622294554 1.1210669730299656 0.9976439663601837 0.8933610036360179 0.9792263030775611 0.9815601827024122 0.9671221116414164 0.9121676836733037 0.993797260662163 1.0 16.823212038772404 -5.524161231204203 24.99828878371199 0.9581840302800175 1.0342957594679605 0.19187091541595613 0.05351859005429758 50.22048628424393 978897.7890758769 0.013580695610579292 0.02376435428916058 2.9911539688284653e-06 5.524161231204203 0.07611172918794296 SSSISEEKGDS(ph)DDEKPR ddPTM_A459_Selumetinib_30min_R1 4 SSSISEEKGDSDDEKPR 17 2 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 SSSISEEKGDS(1)DDEKPR;SSSIS(0.001)EEKGDS(0.999)DDEKPR;S(0.001)SS(0.002)IS(0.037)EEKGDS(0.96)DDEKPR;SSSIS(0.005)EEKGDS(0.995)DDEKPR 109.37 0.0025357 409733000.0 13154.119999999999 17377.0 18964.920000000002 19646.9 12868.39 15800.300000000001 15050.330000000002 14215.64 11293.21 15275.76 True False 13460.585402538078 15342.492761651863 16389.58803084873 16215.937732989098 11704.446396598778 15641.363327524565 13915.071491009796 13838.59504829354 19163.752546576037 17236.55259450286 0.7809325750458345 0.8901137670966144 0.9508622992323739 0.940787761594551 0.6790479901608399 0.9074531140590701 0.8073001497670501 0.802863273988268 1.1118088980674596 1.0 14.073183635870272 -8.25971074457781 24.9996550456218 1.0559044613967377 0.848454926698113 0.5130317731119098 0.08216433962832621 121.40734839823344 1755873.009918948 0.06340715975746741 0.02109961749366252 5.499070093522371e-09 8.25971074457781 -0.2074495346986247 SSSISEEKGDS(ph)DDEKPR ddPTM_A459_Selumetinib_30min_R2 2 SSSISEEKGDSDDEKPR 17 2 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 SSSISEEKGDS(1)DDEKPR;SSSISEEKGDS(1)DDEKPR 79.695 0.01967 240886000.0 87831.0 87364.0 90634.0 73156.0 68648.0 51217.0 60048.0 58456.0 48338.0 72291.0 True False 82949.70463535075 94064.53788046446 84802.70711483782 63192.02659886107 60023.82451909336 58271.67684836489 62840.350982854725 58626.097282088216 58006.95067656653 70203.77099542507 1.1815562534490673 1.339878706609568 1.2079508823018084 0.9001229663714085 0.8549943068301117 0.8300362789936491 0.8951136113037261 0.835084731928555 0.8262654534661198 1.0 16.099260906522034 -5.746517355250194 3.8567920826207387 0.8648773866507873 1.2639700377915633 0.8882501272387435 0.05964351809048509 0.05715672011930642 1.8493859986020773 0.015717253251994488 0.026826305553195172 1.7925969152831033e-06 5.746517355250194 0.39909265114077597 SSSLDALDADS(ph)EGEGHSEPSHICYTPGSQSSSR ddPTM_A459_Selumetinib_30min_R2 1 SSSLDALDADSEGEGHSEPSHICYTPGSQSSSR 33 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(0.002)S(0.002)S(0.004)LDALDADS(0.877)EGEGHS(0.055)EPS(0.031)HICY(0.016)T(0.008)PGS(0.001)QSS(0.002)S(0.002)R 56.332 0.00073213 7729600.0 22454.0 20038.0 22553.0 22062.0 22973.0 18183.0 21188.0 19861.0 12300.0 21044.0 True False 21206.096570483827 21574.85016767485 21101.964533849776 19057.117540927204 20086.926358774235 20687.543201160122 22173.283983225512 19918.792221834447 14760.343690714732 20436.40504112165 1.0376627654332269 1.0557067216206788 1.0325673469178607 0.9325083106632954 0.9828992094429426 1.012288764072406 1.084989455758435 0.9746720219018132 0.7222573471711056 1.0 14.318853814303923 -8.018213109157271 24.089139447371082 0.8569072786752292 1.0175535624651555 0.4218433667488154 0.07328064213381946 410.0040529444922 542277.6843709105 0.0452939415886653 0.017874511257582104 9.589299672246554e-09 8.018213109157271 0.1606462837899263 SSSLEMTPYNTPQLS(ph)PATTPANKK ddPTM_A459_Selumetinib_30min_R1 2 SSSLEMTPYNTPQLSPATTPANKK 24 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8;B0QZ65;A0A0A0MQV8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 SSSLEMTPYNT(0.005)PQLS(0.991)PAT(0.003)TPANKK;SSSLEMTPYNT(0.002)PQLS(0.998)PATTPANKK 132.69 5.3233e-08 110483000.0 7652.4 7353.799999999999 11956.9 11815.8 10497.7 8442.4 8487.9 7984.1 4186.7 6756.4 True False 7830.6860310216425 6492.813677311126 10333.21865455036 9752.392340035958 9548.184888519463 8357.477121085889 7847.650869352505 7772.335731988186 7104.524115530472 7623.649752909121 1.0271571077925659 0.8516673624511046 1.3554162362465942 1.279228801967788 1.2524427535349398 1.0962567001319474 1.029382398680882 1.0195032542021396 0.931905890983442 1.0 12.896266124876862 -7.27409085133622 2.397291110353834 0.9869684698342059 1.1550236278305668 0.2378808928866636 0.13378320419651848 0.5127397272575619 5.792181357761363 0.07140769320537461 0.046656615151442635 5.319969576218169e-08 7.27409085133622 0.16805515799636084 SSSLEMTPYNTPQLS(ph)PATTPANKK ddPTM_A459_Selumetinib_30min_R2 2 SSSLEMTPYNTPQLSPATTPANKK 24 1 Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;F8W9S7;Q14C86-3;H0Y4E7;H0Y7I9;C9IZ08;B4DGD8;B0QZ65;A0A0A0MQV8 Q14C86-4 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 SSSLEMTPYNTPQLS(1)PATTPANKK;SSSLEMTPY(0.02)NT(0.02)PQLS(0.959)PAT(0.001)TPANKK 140.04 2.3604e-08 53214000.0 211921.0 189154.0 245750.0 235580.0 238600.0 136446.0 144365.0 142754.0 108310.0 188710.0 True False 200143.27920697856 203661.50357402815 229938.7125523693 203493.59760183305 208624.93488893614 155240.19796653435 151078.25855382057 143169.39050580325 129975.02643425277 183261.45197253674 1.0921188119636405 1.111316653785699 1.2547031035573566 1.110400443800523 1.1384005345554085 0.8470968460393864 0.8243864540397776 0.7812302530881311 0.709232765730409 1.0 17.483543829345734 -6.7805161866659605 4.575572696850182 0.813995164625536 1.1464687968979912 0.787685394870882 0.0800743599752668 0.0836676410046434 4.221736185162135 0.027758484166094204 0.025531283422697903 1.657615554416888e-07 6.7805161866659605 0.3324736322724552 SSSLGNS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 SSSLGNSPER 10 0 Q5SQI0-7;Q5SQI0-6;Q5SQI0-5;Q5SQI0-4;Q5SQI0-3;Q5SQI0-2;Q5SQI0 Q5SQI0-7 ATAT1 Alpha-tubulin N-acetyltransferase 1 1 SSSLGNS(1)PER;SSSLGNS(1)PER 110.64 0.0093376 7088800.0 3151.7 3677.3999999999996 3421.7 3957.1000000000004 2788.6 2997.2 3368.3 3179.5 1900.57 2627.1000000000004 True False 3225.1284778593526 3246.84829842312 2957.051934052721 3266.0667689666648 2536.3716223673173 2967.0508892398625 3114.2264191661134 3095.169331528469 3225.1284778593526 2964.313875121007 1.0879848132572327 1.0953119120324528 0.9975502118283647 1.1017951899015213 0.8556353103005259 1.000923321292602 1.0505724259847438 1.0441435900245617 1.0879848132572327 1.0 11.533482499548088 -5.253888095708489 24.193675330761224 1.0167458723564382 1.0916483783072966 0.17698812215325843 0.06409832463343088 655.2651986337148 2099392.478563058 0.016873522108444367 0.042655323243989324 5.573293370105005e-06 5.253888095708489 0.07490250595085834 SSSLGNS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 SSSLGNSPER 10 0 Q5SQI0-7;Q5SQI0-6;Q5SQI0-5;Q5SQI0-4;Q5SQI0-3;Q5SQI0-2;Q5SQI0 Q5SQI0-7 ATAT1 Alpha-tubulin N-acetyltransferase 1 1 SSSLGNS(1)PER 138.2 0.0016624000000000005 7965000.0 39729.0 33517.0 42345.0 45160.0 49766.0 36737.0 39029.0 43605.0 43623.0 41557.0 True False 37521.02122778798 36087.64612585879 39620.568801750036 39009.130094654734 43513.95016631516 41797.188284717595 40843.925834496324 43731.883330803656 52348.81892845926 40357.14143194696 0.9297244526364323 0.8942071922193078 0.9817486421470414 0.9665979479848607 1.0782218121095477 1.0356825781429277 1.0120619148254149 1.0836219261105848 1.2971389219113425 1.0 15.30053636895885 -6.252954902671639 0.5898788829420832 1.1204389325017983 0.8929945552346812 0.4595369941392341 0.0780161379660898 0.9323855885402849 0.6685141178178629 0.05674791536601162 0.11497669509932941 5.585281895364062e-07 6.252954902671639 -0.22744437726711708 SSSLIQLTSQNS(ph)SPNQQR ddPTM_A459_Selumetinib_30min_R1 1 SSSLIQLTSQNSSPNQQR 18 0 H7C419;O95639 H7C419 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 SSSLIQLTS(0.001)QNS(0.919)S(0.079)PNQQR 224.36 6.3684e-15 9065600.0 600.85 841.62 1073.1 971.31 1006.6 960.01 1013.4 580.81 442.91 623.77 True False 614.8486359494215 743.0827391414765 927.3789141163674 801.6889422468499 915.5532077296639 950.3531710193383 936.9584221069795 565.405032063233 751.5859211334945 703.8369555343264 0.8735668553843576 1.0557597655231903 1.3176047475545474 1.1390264974623818 1.3008029779206614 1.3502461948703248 1.3312151553560811 0.8033181941036314 1.0678409470030155 1.0 9.45909745573271 -7.758696317448466 24.999999354865107 0.9516846808772796 1.2026194886742514 0.33798509735530136 0.15261683828656303 82.90527289328911 755613.5189788912 0.07994091533533844 0.04348337117954899 1.7430252663448276e-08 7.758696317448466 0.25093480779697175 SSSLIQLTSQNS(ph)SPNQQR ddPTM_A459_Selumetinib_30min_R2 1 SSSLIQLTSQNSSPNQQR 18 0 H7C419;O95639 H7C419 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 SSSLIQLTSQNS(0.96)S(0.04)PNQQR 338.14 5.707499999999998e-163 7645800.0 32338.0 28646.0 31797.0 34667.0 36450.0 27086.0 25583.0 29578.0 25589.0 33048.0 True False 30540.783419270767 30843.056088592384 29751.21563795596 29945.294796089358 31870.825132865557 30816.850637772826 26772.660191752802 29664.067083098485 30707.515016398298 32093.818370984016 0.9516095301044843 0.9610279379058727 0.9270076652784326 0.9330549095137544 0.993051832114808 0.9602114114796109 0.8341999036162656 0.9242922341056723 0.9568046613039016 1.0 14.970007824425252 SSSLIQLTSQNSS(ph)PNQQR ddPTM_A459_Selumetinib_30min_R2 1 SSSLIQLTSQNSSPNQQR 18 0 H7C419;O95639 H7C419 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 SSSLIQLTSQNS(0.227)S(0.772)PNQQR 209.23 1.3984000000000003e-11 8148900.0 29058.0 31398.0 33685.0 35880.0 38002.0 26534.0 29646.0 26484.0 29011.0 34157.0 True False 27443.07268839044 33806.12563951769 31517.743773454924 30993.082103547677 33227.84901780953 30188.817648329932 31024.59774243455 26561.064055337774 34814.01063506705 33170.798659455984 0.8273262567516521 1.0191532011810813 0.9501653576999471 0.9343483833999424 1.0017198970377303 0.9101022244975105 0.935298485301631 0.8007363442774997 1.049537908100462 1.0 15.017626128128965 -7.3197725434474155 0.004354904532082884 1.8847916018524347 2.5304059985027765e-05 0.04593361552813213 0.07485699110578384 54237.745108983974 149.38758002836414 32120.727681141874 32524.299496718668 4.788808347780887e-08 7.3197725434474155 -1.8847662977924495 SSSMS(ph)YVDGFIGTWPK ddPTM_A459_Selumetinib_30min_R1 1 SSSMSYVDGFIGTWPK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 S(0.002)S(0.002)S(0.096)MS(0.899)YVDGFIGTWPK 192.4 1.1089e-06 58951000.0 4737.0 5010.7 5387.5 5188.0 5874.7 4932.3 4503.7 4649.3 2568.1 3648.4 True False 4847.3628834025285 4424.044914588767 4655.907091419185 4282.0131908213225 5343.334422262525 4882.685540170085 4163.982283050327 4525.98546094521 4357.87813339714 4116.7076784254405 1.1774853261518314 1.0746560747497322 1.1309783096379527 1.040154785160531 1.297963042230447 1.1860656431251917 1.0114835952216477 1.0994187138097478 1.0585833325585903 1.0 12.007275293229245 -7.260889925311237 24.999683698989493 1.0506563024226168 1.1484391712187674 0.3663146677739366 0.06973688456640594 65.56789687649197 2983381.089218569 0.029059761871952073 0.021138403164775756 5.484159468044726e-08 7.260889925311237 0.09778286879615061 SSSMSYVDGFIGT(ph)WPK ddPTM_A459_Selumetinib_30min_R1 1 SSSMSYVDGFIGTWPK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 SSSMSYVDGFIGT(1)WPK 195.23 2.9212e-06 16372000.0 1628.5 1851.3 2125.4 2173.3 1710.0 1724.8 1975.2 1780.9 1061.1 1803.5 True False 1666.4408814906103 1634.54893535398 1836.7823539865128 1793.773952893596 1555.3308019250214 1707.4500779931 1826.2090737573578 1733.6647468215285 1800.6092003223023 2034.9967925776457 0.8188911587323924 0.8032194160284474 0.9025971739542337 0.8814627912123131 0.7642915249782525 0.8390431298077595 0.897401450664782 0.8519250512555194 0.8848216404516027 1.0 10.99081080527844 -9.461024343646157 0.46344511835500984 1.0181119867861208 0.8353561516768558 0.5934549854078396 0.03944839500838089 2.946045828535962 0.8425173597406317 0.14128614278098162 0.02358240160332977 3.4591998732005645e-10 9.461024343646157 -0.18275583510926496 SSSMSYVDGFIGT(ph)WPK ddPTM_A459_Selumetinib_30min_R2 1 SSSMSYVDGFIGTWPK 16 0 Q08AD1-2;Q08AD1-3;Q08AD1 Q08AD1-2 CAMSAP2 Calmodulin-regulated spectrin-associated protein 2 1 SSSMSYVDGFIGT(1)WPK 102.29 0.014196 0.0 5250.7 5290.2 9516.7 6923.3 7169.6 5331.1 6090.2 5387.3 5344.4 5171.0 True False 4958.887114217485 5695.941329325958 8904.405882999514 5980.334596641348 6268.890750962767 6065.410634092545 6373.40636750236 5402.976151084473 6413.429335012662 5021.699794128494 0.9874917493107709 1.1342655998643736 1.7731856240014154 1.1908984690071907 1.248360317813606 1.2078401502981888 1.2691731144411136 1.0759257567331637 1.2771431184539177 1.0 12.293960069052522 -8.87200146504132 0.49200693693358644 0.9937657030955702 1.279801824916339 0.11618621398309936 0.19808020320951644 3.556957647389113 1.7528075480718228 0.3035582792334693 0.11297366261412269 1.342760431485945e-09 8.87200146504132 0.28603612182076876 SSSNDS(ph)VDEETAESDTSPVLEK ddPTM_A459_Selumetinib_30min_R1 2 SSSNDSVDEETAESDTSPVLEK 22 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 S(0.177)S(0.177)S(0.048)NDS(0.527)VDEET(0.071)AESDTSPVLEK;S(0.031)S(0.031)S(0.123)NDS(0.811)VDEET(0.004)AESDTSPVLEK 179.55 2.1492e-16 14127300.0 8011.5 10555.099999999999 9209.9 9313.400000000001 9234.8 8293.7 9415.3 8233.0 4532.7 7540.099999999999 True False 8198.152362334673 9319.303985067136 7959.246166359453 7686.989524170264 8399.513970536364 8210.272908077095 8705.096340698487 8014.63409544704 7691.660844690324 8507.945281793574 0.9635878100765601 1.0953648238676164 0.935507446597206 0.9035071653105128 0.9872552881258831 0.9650124249913221 1.0231725819072675 0.9420175882651494 0.9040562192084094 1.0 13.054595039406498 -5.286144911534342 24.996813620497395 0.9572339690866706 1.0294763457761935 0.27113336485727735 0.047158494178138825 859.4169507760777 869548.1979538605 0.012253270696476668 0.025527549966741458 5.174341503005541e-06 5.286144911534342 0.07224237668952294 SSSNDS(ph)VDEETAESDTSPVLEK ddPTM_A459_Selumetinib_30min_R2 1 SSSNDSVDEETAESDTSPVLEK 22 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 S(0.168)S(0.168)S(0.145)NDS(0.519)VDEETAESDTSPVLEK 112.99 2.6055e-05 2776000.0 73731.0 64520.0 73826.0 79009.0 81224.0 61840.0 56833.0 65185.0 53755.0 69768.0 True False 69633.32618857852 69468.47653550169 69076.11553567118 68247.83790187277 71019.91496822698 70357.89867237206 59475.84711245302 65374.67755804232 64507.50204019272 67753.61656096642 1.0277433105865381 1.025310235255002 1.0195192381135072 1.0072943905579068 1.0482084731863939 1.0384375365271055 0.877825422926836 0.9648883834742096 0.9520894280550654 1.0 16.04801033642653 -7.231521394599213 24.99483528684308 0.9457748272427631 1.0272669125606932 0.624695379693344 0.029981681260116657 423.16982703985434 353535.7640364009 0.011032005382063224 0.008544072036481394 5.86784462211138e-08 7.231521394599213 0.08149208531793017 SSSPAGET(ph)EGDREPQARPGEGTAPLPPPGQK ddPTM_A459_Selumetinib_30min_R1 1 SSSPAGETEGDREPQARPGEGTAPLPPPGQK 31 2 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(0.003)S(0.003)S(0.011)PAGET(0.982)EGDREPQARPGEGT(0.001)APLPPPGQK 94.087 3.3407e-07 41253000.0 554.63 971.78 1045.4 1308.7 948.13 745.75 941.82 999.16 399.37 567.45 True False 567.5517998778859 858.003545831735 903.4404219711585 1080.160112341531 862.3718089059469 738.2484320868241 870.7777591363676 972.6590310709176 677.7017211692756 640.2877349310702 0.8864011739018948 1.3400280827245628 1.4109912976365506 1.6869917279577673 1.3468504265489094 1.1529948050095007 1.359978821443629 1.5190967716656774 1.0584330828111728 1.0 9.322576564374039 -8.394927226814646 6.100619863803299 1.0040168942186516 1.346331327564665 0.27694398070444337 0.19993234748301916 0.30348615423845493 12.910097126478586 0.19839580916574837 0.05144975477748626 4.027845218441306e-09 8.394927226814646 0.3423144333460133 SSSPAGET(ph)EGDREPQARPGEGTAPLPPPGQK ddPTM_A459_Selumetinib_30min_R2 2 SSSPAGETEGDREPQARPGEGTAPLPPPGQK 31 2 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 S(0.02)S(0.02)S(0.064)PAGET(0.893)EGDREPQARPGEGT(0.002)APLPPPGQK;S(0.14)S(0.14)S(0.164)PAGET(0.53)EGDREPQARPGEGT(0.026)APLPPPGQK 69.28399999999999 0.00074423 28969000.0 48439.0 45421.0 46751.0 54255.0 48371.0 38039.0 34774.0 35411.0 31862.0 54144.0 True False 45746.95429668057 48904.64464846589 43743.09155864011 46865.37540490461 42294.2025377734 43278.526966338344 36391.0599033738 35514.04014739335 38235.29029866283 52580.72203699345 0.8700328280865951 0.9300869739684967 0.8319226108737042 0.8913033824817435 0.8043670930957755 0.8230873462690281 0.6920989003873069 0.675419407942083 0.7271731695080601 1.0 15.682246332689083 -6.615957074208404 1.5837506932710546 0.7510669831774394 0.882648414660221 0.1816436135082422 0.08963367385238061 0.48377683786190717 2.5006486836852893 0.03551594399016934 0.03627011098866804 2.4212683537704064e-07 6.615957074208404 0.13158143148278167 SSSPAPADIAQTVQEDLR ddPTM_A459_Selumetinib_30min_R1 2 SSSPAPADIAQTVQEDLR 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 ; 177.88 2.6691e-08 5418700.0 1462.98 1720.8 2166.54 1854.49 2005.1 1631.21 1701.27 1334.56 895.41 1317.26 False True 1497.0645875364642 1519.3279360217832 1872.3357679523576 1530.6381345887119 1823.7390590291575 1614.8015084201784 1572.9418341996654 1299.163133538177 1519.445371841102 1486.3431521989621 1.0072132974956962 1.0221919035143547 1.2596928005369021 1.029801316287035 1.2269973164212025 1.086425773234915 1.0582629131587717 0.8740667534385563 1.0222709134113257 1.0 10.537551514148003 -7.563441471487175 6.159957353457927 0.960617589293403 1.1078770869062868 0.3445955298547856 0.08612402380395165 0.2025632810733977 19.92824808886533 0.040433771530804435 0.0233054933091298 2.7324896681760545e-08 7.563441471487175 0.14725949761288382 SSSPAPADIAQTVQEDLR ddPTM_A459_Selumetinib_30min_R2 2 SSSPAPADIAQTVQEDLR 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 ; 172.82 6.0802e-07 7694600.0 19698.3 18778.7 23681.0 24302.5 23110.6 17507.3 16455.3 16654.0 14511.6 20241.1 False True 18603.547344542687 20218.96590696255 22157.390241923305 20992.45757584914 20207.239816614623 19918.771659554033 17220.50405555836 16702.46038278188 17414.325487981776 19656.686850306374 0.9464233462239201 1.0286049760541112 1.1272189667903243 1.0679550290298259 1.0280084314564775 1.0133331120978597 0.8760634071600909 0.8497088298744278 0.8859237378404058 1.0 14.262732554359427 -7.164704342555184 3.7563388541180025 0.8901395250759255 1.0436627507996692 0.5682773739606014 0.056250363252087564 0.16614959269355747 4.305601771680906 0.023450236215745542 0.017612981210870543 6.843773967253598e-08 7.164704342555184 0.15352322572374366 SSSPATEQS(ph)WMENDFDELREEGFR ddPTM_A459_Selumetinib_30min_R1 1 SSSPATEQSWMENDFDELREEGFR 24 1 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 S(0.003)S(0.003)S(0.024)PAT(0.238)EQS(0.733)WMENDFDELREEGFR 61.304 0.0038481 18999000.0 173.05 295.2 182.84 196.23 368.96 189.91 263.87 288.91 0.0 222.94 True False 177.08172830331597 260.6378467652433 158.01133226822904 161.96211419330527 335.58763314517887 187.99967782448368 243.96607345704408 281.24716828806083 0.0 251.55652061949553 0.7039440991918069 1.0361005396456575 0.6281345117952122 0.6438398567226536 1.334044660495161 0.7473456754828155 0.969826076685435 1.1180277402289063 0.0 1.0 7.974738776112453 -11.783145376730618 2.364980499414408 1.7260111876321562 0.8241502731032456 0.025182135712089382 0.34394866066113816 78769614.30232523 17506623.988579363 303850422.24318725 0.08315890505062258 1.647610774197657e-12 11.783145376730618 -0.9018609145289106 SSSPNS(ph)PLPMFR ddPTM_A459_Selumetinib_30min_R1 1 SSSPNSPLPMFR 12 0 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 SSS(0.067)PNS(0.933)PLPMFR 132.06 0.0019374 4178300.0 1137.7 1277.7 1499.6 1530.3 1198.9 1131.7 1133.7 1484.8 645.92 1056.1 True False 1164.206196421165 1128.106290013385 1295.9625567131711 1263.0618322887183 1090.4597066829872 1120.316125501386 1048.1840962528934 1445.4182806898777 1096.0790638697397 1191.6607222851408 0.9769611221125686 0.9466673432435676 1.0875264515121552 1.0599173142726883 0.9150756471958819 0.9401301096448462 0.8795994335056079 1.2129444678835506 0.9197912152108927 1.0 10.218757829229604 SSSPNS(ph)PLPMFR ddPTM_A459_Selumetinib_30min_R2 2 SSSPNSPLPMFR 12 0 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 S(0.06)S(0.004)S(0.004)PNS(0.931)PLPMFR;S(0.387)S(0.012)S(0.116)PNS(0.485)PLPMFR 125.47 0.0028725 6977700.0 23877.3 20645.4 17919.3 25910.6 22834.0 21183.8 21919.4 20269.4 19006.9 18265.800000000003 True False 22550.295254405162 22228.835794576033 16766.391747058668 22381.53158172189 19965.388781449998 24101.676162609903 22938.695532467114 20328.380598220203 22808.811097158195 17738.418893752136 1.271268616976222 1.2531464009120634 0.9452021540073203 1.2617545969446669 1.125545004943042 1.3587274213655562 1.2931646089689894 1.1460085997506975 1.2858423985686775 1.0 14.1145898009246 -5.027298105513759 24.993851702659615 1.1877427824344438 1.2667383772600311 0.06526855142001997 0.12456120143486035 1968.5160709765773 1802357.4556362 0.0314500381717619 0.0837490135466015 9.3907849330545e-06 5.027298105513759 0.07899559482558738 SSSPRGEASS(ph)LNGESH ddPTM_A459_Selumetinib_30min_R2 1 SSSPRGEASSLNGESH 16 1 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 S(0.025)S(0.028)S(0.259)PRGEAS(0.135)S(0.549)LNGES(0.005)H 72.417 0.020555 8097600.0 36565.0 50425.0 57874.0 65128.0 62450.0 26505.0 16997.0 14528.0 18353.0 59245.0 True False 34532.86368129247 54292.43535806988 54150.44984844681 56257.45404793342 54604.47268991645 30155.823161565717 17787.394178916544 14570.274074760118 22024.11282566565 57534.44291300381 0.6002120109776439 0.9436510133619251 0.9411831784019559 0.9778047930871375 0.949074500859986 0.524135137749808 0.3091607961827727 0.25324437566539776 0.38279874994127744 1.0 15.812138261575258 -6.8485947152835855 4.615728615845449 0.4240851496121368 0.8942450637886542 0.42897010979994243 0.21890663938049584 0.17171405686867877 6.509737326955974 0.07578922536205293 0.06724484389400305 1.417115618993612e-07 6.8485947152835855 0.4701599141765174 SSSPT(ph)AGPSTEGAEGPEEK ddPTM_A459_Selumetinib_30min_R2 1 SSSPTAGPSTEGAEGPEEK 19 0 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;A0A0C4DGG3 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 S(0.05)S(0.05)S(0.353)PT(0.547)AGPSTEGAEGPEEK 147.7 9.3427e-05 8976700.0 44687.0 37841.0 39561.0 51272.0 44601.0 28673.0 41961.0 39188.0 34193.0 39256.0 True False 42203.47543623454 40743.28302200742 37015.68833076 44288.66515086668 38997.82364200102 32622.44548242119 43912.269644144115 39302.03059207736 41032.55543224459 38122.57728066295 1.107046754093448 1.0687441911928075 0.9709650021362958 1.1617437306194767 1.0229587405619092 0.8557250797145971 1.1518704341749186 1.030938446336698 1.076332146438003 1.0 15.21835803563736 -5.003522866618312 16.718435250509316 1.0358182824021458 1.0974761008918719 0.07103390810767007 0.08316846200972201 5.976403897699359 28526.89602485262 0.020687440174028834 0.07070128121467702 9.91921110902041e-06 5.003522866618312 0.06165781848972607 SSSPVT(ph)ELASRS(ph)PIRQDR ddPTM_A459_Selumetinib_30min_R1 1 SSSPVTELASRSPIRQDR 18 2 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 S(0.01)S(0.014)S(0.121)PVT(0.837)ELAS(0.041)RS(0.977)PIRQDR 121.72 0.014352 29646000.0 2259.7 1716.9 3493.6 3479.0 2855.7 2024.8 1894.6 1657.5 1476.6 1365.3 True False 2312.346613389211 1515.8845498348435 3019.188308971148 2871.457958918154 2597.402439214784 2004.432350371304 1751.6887966487898 1613.537715681218 2505.6823534029877 1540.5495541481891 1.500988142291709 0.9839894768416043 1.9598125232917534 1.863917944856931 1.686023297479033 1.301115141005385 1.137054495866149 1.047378003087597 1.626486046265773 1.0 10.589229374292852 -6.879665546454359 4.9013455665991374 1.208674104280478 1.5983664782491354 0.2987327964545238 0.29094660683023194 0.30088942241368616 11.636752620218196 0.11060574133226175 0.09750020211523427 1.3192723292922252e-07 6.879665546454359 0.3896923739686573 SSSQPS(ph)SCCSDPSKPGGNVEGATQSLAEQMR ddPTM_A459_Selumetinib_30min_R2 2 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.025)S(0.025)S(0.192)QPS(0.247)S(0.247)CCS(0.079)DPS(0.176)KPGGNVEGAT(0.005)QS(0.005)LAEQMR;S(0.051)S(0.02)S(0.137)QPS(0.492)S(0.202)CCS(0.066)DPS(0.029)KPGGNVEGAT(0.002)QS(0.001)LAEQMR 53.236 0.011258 28669600.0 67350.0 55943.0 80755.0 76330.0 79890.0 61602.0 70978.0 72436.0 65247.0 62123.0 True False 63606.956623411716 60233.64821490343 75559.3112193959 65933.72232340551 69853.5039743383 70087.11633272104 74278.61764023874 72646.7767675747 78298.22315350108 60329.3475750618 1.0543286009229904 0.9984137179663793 1.2524470138747144 1.0928963261432711 1.157869375057082 1.1617416589085208 1.231218646079692 1.2041697728818888 1.297846343458006 1.0 15.880572360135114 -5.251094562842283 24.96335031031799 1.1800879714377248 1.0263711430563711 0.3510399274850625 0.0804516645469021 703.7009860530976 1698111.1056604835 0.01963156217237139 0.05074992689271592 5.6092582731102316e-06 5.251094562842283 -0.1537168283813537 SSSQPSS(ph)CCSDPSKPGGNVEGATQSLAEQMR ddPTM_A459_Selumetinib_30min_R1 1 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.001)S(0.001)S(0.003)QPS(0.197)S(0.447)CCS(0.148)DPS(0.197)KPGGNVEGAT(0.003)QS(0.002)LAEQMR 55.012 0.006871 10785000.0 1072.3 1221.8 1145.5 1172.4 882.78 978.72 979.1 1119.8 485.91 891.78 True False 1097.2825036674117 1078.7510880005896 989.9473917811002 967.6623486736542 802.932704867468 968.8749654066597 905.2456987220673 1090.0992663769703 824.5537805377534 1006.2486496727987 1.09046854773342 1.0720522093136389 0.9837999704178494 0.9616533140077339 0.7979466160064485 0.9628584005769432 0.8996242618724761 1.0833299172440503 0.8194334281152805 1.0 9.97477113187775 -5.394989793840677 2.0362575240481258 0.929850619269716 1.0908793659457958 0.36720660436497143 0.07799158112212677 0.3704066562441934 2.8933854329684974 0.021811244631625013 0.06751121906455343 4.027264985085932e-06 5.394989793840677 0.1610287466760798 SSSQPSS(ph)CCSDPSKPGGNVEGATQSLAEQMR ddPTM_A459_Selumetinib_30min_R2 1 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 SSS(0.001)QPS(0.061)S(0.771)CCS(0.038)DPS(0.129)KPGGNVEGATQSLAEQMR 127.14 2.5549e-18 5395500.0 21991.0 22145.0 23148.0 26107.0 23876.0 20867.0 25172.0 22453.0 19084.0 20387.0 True False 20768.828256947978 23843.450292602032 21658.682881636778 22551.181562913018 20876.483425851795 23741.239838233974 26342.54787737174 22518.33451270575 22901.33325151217 19798.37433821264 1.0490168486643003 1.2043135403588179 1.0939626916657281 1.1390420838435815 1.0544544248543835 1.1991509723306548 1.3305409538867166 1.1373830056967527 1.156727964644579 1.0 14.27309435376924 -6.787957677338218 24.98500657283637 1.1837083119731284 1.1144270277341402 0.0739149520457818 0.08683346710244964 468.4816565149717 441390.6665339253 0.02988052843718827 0.026359764048125556 1.6294548177679147e-07 6.787957677338218 -0.06928128423898827 SSSQPSSCCS(ph)DPSKPGGNVEGATQSLAEQMR ddPTM_A459_Selumetinib_30min_R2 1 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.002)S(0.002)S(0.019)QPS(0.137)S(0.137)CCS(0.53)DPS(0.174)KPGGNVEGATQSLAEQMR 108.47 1.9206e-11 90325000.0 21458.0 18187.0 22389.0 23698.0 21710.0 19611.0 22977.0 25492.0 17823.0 22280.0 True False 20265.450263179908 19581.884419577924 20948.516115300055 20470.29151866979 18982.595710137477 22312.237239066788 24045.476028061756 25566.17749957223 21388.098016228352 21636.718509607963 0.9366230953266258 0.9050302341772588 0.9681928480050103 0.9460903930316322 0.8773324708045769 1.0312209418058869 1.1113273030466317 1.1816106720720778 0.9885093253272575 1.0 14.401194091796526 -6.941424943824094 4.981361135475073 1.0840712877732592 0.9294327062263318 0.5940439071227042 0.05634044953576708 0.12877764450789542 6.549967925341352 0.019994835861096644 0.017389926549162122 1.144392640362216e-07 6.941424943824094 -0.15463858154692744 SSSQPSSCCSDPS(ph)KPGGNVEGATQSLAEQMR ddPTM_A459_Selumetinib_30min_R1 3 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 S(0.001)S(0.001)S(0.008)QPS(0.054)S(0.054)CCS(0.032)DPS(0.85)KPGGNVEGATQSLAEQMR;S(0.002)S(0.002)S(0.018)QPS(0.047)S(0.122)CCS(0.315)DPS(0.481)KPGGNVEGAT(0.012)QS(0.001)LAEQMR;SSSQPS(0.015)S(0.043)CCS(0.121)DPS(0.821)KPGGNVEGATQSLAEQMR 114.73 5.3287e-16 128383000.0 5888.900000000001 7013.6 7114.299999999999 7060.900000000001 6436.1 6731.5 6676.5 6772.7 3346.92 5322.5 True False 6026.099912195302 6192.44445146582 6148.217136052622 5827.846364508537 5853.955891385749 6663.787221712981 6172.886229719011 6593.065995169947 5679.478790634924 6005.6947205403485 1.0033976405069616 1.0310954418456804 1.0237312121485007 0.9703867138928083 0.9747341754425795 1.1095780807708824 1.0278388291377587 1.0978023862286412 0.9456822324335403 1.0 12.552115426830525 SSSS(ph)DSIHSVR ddPTM_A459_Selumetinib_30min_R1 1 SSSSDSIHSVR 11 0 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 S(0.027)S(0.027)S(0.16)S(0.785)DS(0.001)IHSVR 70.563 0.043598000000000005 1023200.0 749.31 1275.1 999.61 1225.6 1019.7 944.88 737.94 1154.9 676.67 721.73 True False 766.7674650965482 1125.810699222092 863.868452464693 1011.5719673613366 927.4683150426569 935.3753650823979 682.2765916810977 1124.2683003561028 1148.2595679785993 814.3710757455304 0.9415455532904301 1.3824296229964315 1.0607798805647035 1.2421511488915236 1.138876788070585 1.1485861825655976 0.8377957076342568 1.380535647495672 1.4099955194594855 1.0 9.669542511478701 SSSS(ph)DSIHSVR ddPTM_A459_Selumetinib_30min_R2 1 SSSSDSIHSVR 11 0 Q8WYL5-4;Q8WYL5 Q8WYL5-4 SSH1 Protein phosphatase Slingshot homolog 1 1 S(0.015)S(0.079)S(0.309)S(0.595)DS(0.001)IHSVR 96.866 0.013102 1149500.0 3315.0 3395.7 4651.7 5603.5 8103.2 3997.3 4438.6 4852.3 4844.2 6525.7 True False 3130.7655709964297 3656.139271103579 4352.414686388017 4840.2936334233345 7085.203572472875 4547.891791123433 4645.003694919046 4866.419389658493 5813.175358256936 6337.286085195189 0.4940230768988555 0.57692507833043 0.6867947300905166 0.7637801999709238 1.118018577230548 0.7176402848133938 0.732964179378053 0.7679027464180839 0.9172972910024292 1.0 12.629649429494178 -5.508440333592569 1.8382634419671573 0.8520795631996557 0.5198213000925832 0.5540744478411193 0.1193932035161346 0.3036783044313667 1.9818640444758295 0.03680370108843358 0.10354905875052006 3.101413453092805e-06 5.508440333592569 -0.3322582631070725 SSSS(ph)PELQTLQDILGDPGDKADVGR ddPTM_A459_Selumetinib_30min_R2 2 SSSSPELQTLQDILGDPGDKADVGR 25 1 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;H3BQK4;A0A2R8Y670 P49815 TSC2 Tuberin 1 S(0.026)S(0.026)S(0.426)S(0.521)PELQT(0.003)LQDILGDPGDKADVGR;S(0.015)S(0.015)S(0.064)S(0.902)PELQT(0.003)LQDILGDPGDKADVGR 99.971 2.2217e-06 6881000.0 25470.9 24553.6 27635.1 32447.0 33698.0 21821.9 27837.9 23229.2 18059.2 28343.0 True False 24055.32934609139 26436.78216773237 25857.08775282185 28027.662625802976 29464.555976057694 24827.668645514823 29132.41750975237 23296.793126198914 21671.544616207753 27524.66394604215 0.8739554238790397 0.960476110428 0.9394152024348299 1.0182744712432048 1.0704783184208317 0.9020153232092363 1.0584113784953733 0.8463970049504937 0.7873500166502111 1.0 14.748437329303195 -10.37215839471757 4.981048613277349 1.000000097065527 0.9460525753227118 0.03694411479479043 0.08708006384701317 1.0025624907751439e-07 2.3138125130608717e-08 0.08739463187741545 0.02119627250188305 4.2446472607659064e-11 10.37215839471757 -0.05394752174281514 SSSS(ph)PTEATEK ddPTM_A459_Selumetinib_30min_R1 1 SSSSPTEATEK 11 0 E7EME3;Q9UBG0 E7EME3 MRC2 C-type mannose receptor 2 1 SS(0.006)S(0.072)S(0.922)PT(0.001)EATEK 179.94 5.0623e-05 4451100.0 3155.8 3340.0 4166.7 3530.4 4058.3 3717.9 3299.0 4317.8 2294.3 3779.8 True False 3229.323999882141 2948.9512472761276 3600.885026044793 2913.88191381565 3691.227481551061 3680.501301583106 3050.1537739598634 4203.277917808967 3893.2595309579315 4264.974148369826 0.7571731709362095 0.6914347296579245 0.8442923452235077 0.6832120928398603 0.8654747609576802 0.8629598148888852 0.7151634846663031 0.9855342076142616 0.9128448134781841 1.0 12.058321281508892 -7.731088704843013 0.46172628417498357 1.0116833931953344 0.734192150261059 0.5501693679194499 0.07399209677488545 0.7150195891926969 0.3731450215350599 0.07739430959527784 0.05849648189130438 1.857425036446757e-08 7.731088704843013 -0.2774912429342754 SSSS(ph)PTEATEK ddPTM_A459_Selumetinib_30min_R2 2 SSSSPTEATEK 11 0 E7EME3;Q9UBG0 E7EME3 MRC2 C-type mannose receptor 2 1 SSS(0.059)S(0.939)PT(0.002)EATEK;SSS(0.413)S(0.582)PT(0.005)EATEK 214.04 2.0145e-05 10838700.0 97836.0 32729.0 52595.0 70444.0 50624.0 40409.0 124293.0 114758.0 63457.0 69641.0 True False 92398.66678853896 35239.20905967811 49211.0949611062 60849.4056773219 44264.160535697825 45974.9729536204 130072.87078190695 115091.92678079038 76150.17313672238 67630.28338095188 1.3662321399434372 0.5210566524049678 0.7276488061406903 0.8997360743642866 0.654502071008102 0.6797986146923242 1.92329329819934 1.701780933439148 1.1259774368795583 1.0 16.045381778429864 -7.244604342329576 24.9884982676172 1.496244675080792 0.7886302703664055 0.468987471857945 0.3254366257781969 631.4138817346712 937218.3763193671 0.12135644850108011 0.0937449218064258 5.693714121734406e-08 7.244604342329576 -0.7076144047143865 SSSS(ph)QTLTQFDSNIAPADPDTAIVHPVPIR ddPTM_A459_Selumetinib_30min_R2 1 SSSSQTLTQFDSNIAPADPDTAIVHPVPIR 30 0 Q96D71;Q96D71-3;H0YE73 Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 S(0.005)S(0.005)S(0.106)S(0.526)QT(0.358)LTQFDSNIAPADPDTAIVHPVPIR 172.38 4.1752e-28 3981600.0 4862.5 2566.4 4203.4 6507.6 7022.7 5217.2 4202.9 5171.1 2831.2 3734.0 True False 4592.261716129756 2763.2346277233632 3932.9578203158817 5621.253653763844 6140.445642265428 5935.821942973804 4398.343177888353 5186.147044878308 3397.519110337522 3626.1897179028806 1.2664151832589663 0.7620215274675185 1.084597918553035 1.550181896443841 1.693360281716481 1.6369308846881412 1.2129379652071897 1.4301918675886576 0.9369391495330793 1.0 11.824238691795335 -5.622217790437132 6.060592643309781 1.3884907746340096 0.993002762793909 0.2218939206915087 0.26403513284370633 0.2583693977251528 13.240365214528497 0.0729687879029465 0.127802923179122 2.3866141410869705e-06 5.622217790437132 -0.39548801184010063 SSSS(ph)SQESLNRPFSSK ddPTM_A459_Selumetinib_30min_R1 1 SSSSSQESLNRPFSSK 16 1 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 S(0.001)S(0.003)S(0.011)S(0.493)S(0.493)QESLNRPFSSK 199.15 4.0911000000000005e-06 10140000.0 3300.1 3415.8 4193.9 4641.2 4012.2 3117.4 3912.2 3776.5 1755.1 3708.9 True False 3376.985909123217 3015.87654803766 3624.391415443698 3830.701546114096 3649.297218411442 3086.041786372733 3617.099604269712 3676.3349521991704 2978.2765125677806 4184.973442745343 0.806931263799828 0.7206441305537281 0.8660488447606722 0.9153466798587747 0.8720000899258998 0.7374101242440118 0.8643064654424412 0.8784607602641068 0.711659596724712 1.0 12.031002752326318 -12.010118788223409 2.361572373389995 3.508283561954849 0.8227247362242278 0.379088351818343 0.06928444568633448 3392204.9900481817 661493.2445549694 46067553.46388524 0.018179573277742948 9.769699635903014e-13 12.010118788223409 -2.685558825730621 SSSS(ph)SQESLNRPLSAK ddPTM_A459_Selumetinib_30min_R1 1 SSSSSQESLNRPLSAK 16 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.081)S(0.211)S(0.081)S(0.321)S(0.259)QES(0.047)LNRPLSAK 65.765 0.030172000000000008 10656000.0 2185.1 2698.5 2515.1 2921.2 2513.3 2059.2 2526.5 1685.5 917.3 1733.7 True False 2236.0085785355427 2382.558365501385 2173.563234455388 2411.067257715353 2285.972458759156 2038.486317604006 2335.924070903179 1640.7950647244002 1556.5911030587574 1956.2372826680692 1.1430150106769765 1.2179291268040173 1.1110938605008656 1.232502457179914 1.1685558183623657 1.042044508437013 1.1940903547841923 0.8387505336196005 0.7957066951181694 1.0 10.933865657900265 -7.76288223493062 24.99999928439829 0.8629213862549521 1.1576853695409708 0.7655365118486277 0.07093787623506882 16.54123026187257 286585.602996991 0.03531575128773223 0.01840298491337112 1.726305940713382e-08 7.76288223493062 0.2947639832860187 SSSSAS(ph)DGESEGKR ddPTM_A459_Selumetinib_30min_R1 1 SSSSASDGESEGKR 14 1 K7EJD2;A0A0A0MR03;Q9Y5B0;A0A0J9YWJ4;A0A0J9YWB6;Q9Y5B0-4 K7EJD2 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 SSSSAS(0.995)DGES(0.005)EGKR 150.12 0.00076683 1944400.0 810.15 1655.3 1217.2 778.38 730.77 1096.5 658.66 1242.7 1642.0 963.86 True False 829.0249187225164 1461.4967064719083 1051.9109256010088 642.450545002217 664.6719825279221 1085.4702055423427 608.9767459097917 1209.7395591415084 2786.3540730649524 1087.5808197914546 0.7622651150481702 1.3438051498114436 0.9672025347069971 0.590715221628686 0.6111472089544334 0.9980593495115916 0.5599370040624329 1.1123215278598586 2.5619742665186394 1.0 10.086906898478562 -8.01716668156493 23.96948505939755 1.799707789493732 0.8458064687009428 0.449294763451064 0.41416667932382945 352.27010638292455 491863.23371188 0.2512836176632203 0.10007166971351 9.61243283860742e-09 8.01716668156493 -0.9539013207927891 SSSSGDQSSDSLNS(ph)PTLLAL ddPTM_A459_Selumetinib_30min_R1 1 SSSSGDQSSDSLNSPTLLAL 20 0 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 1 SSSSGDQSSDSLNS(0.859)PT(0.141)LLAL 163.71 2.9483e-07 4779000.0 1482.8 1383.5 1524.5 1995.1 1718.5 1556.8 1265.6 1432.4 942.36 1204.8 True False 1517.3463549734574 1221.5191768282998 1317.4812734790808 1646.6932376653087 1563.0619784258183 1541.1400054613032 1170.1347730595946 1394.4080989090673 1599.1160927487745 1359.4478157457988 1.116149025654975 0.8985406888591522 0.9691297144468212 1.2112956588642028 1.149777108265326 1.1336514631978185 0.8607426923685583 1.025716531931819 1.1762982545023197 1.0 10.408805057275435 SSSSGDQSSDSLNS(ph)PTLLAL ddPTM_A459_Selumetinib_30min_R2 2 SSSSGDQSSDSLNSPTLLAL 20 0 P15408;P15408-3;P15408-2 P15408 FOSL2 Fos-related antigen 2 1 SSSSGDQSSDSLNS(0.998)PT(0.002)LLAL;SSSSGDQSSDSLNS(1)PTLLAL 155.86 1.7609e-06 5655200.0 23974.3 28483.4 30769.0 29434.3 32389.0 23756.8 23519.4 23750.1 25022.0 28349.9 True False 22641.904382726927 30667.985191433763 28789.356038754187 25425.297563000368 28320.00425866619 27029.083557241425 24613.098702806965 23819.208858959282 30027.099173094604 27531.36472511378 0.8224039966341826 1.1139289859996948 1.04569302416356 0.9235029871151907 1.0286451304331101 0.98175603814459 0.894002129881894 0.8651662965777968 1.0906505897146552 1.0 14.748788505405715 -7.016591827222185 23.833817857352958 0.9493129633649102 0.9948024310301848 0.003993143374290131 0.0924211003552428 1399.5044021335937 2010356.3794442369 0.033910383179484305 0.027013643721834596 9.625164769791621e-08 7.016591827222185 0.04548946766527462 SSSSS(ph)QESLNRPFSSK ddPTM_A459_Selumetinib_30min_R1 1 SSSSSQESLNRPFSSK 16 1 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 SSS(0.014)S(0.014)S(0.973)QESLNRPFSSK 194.58 5.776100000000001e-06 8815700.0 3846.8 4365.5 4514.5 5076.4 4803.1 3284.3 3741.2 3752.5 2210.3 3236.5 True False 3936.4229554301965 3854.3852305341093 3901.45569637344 4189.902035829871 4368.66045305618 3251.2629239058074 3458.9982719426 3652.971510162156 3750.717666075189 3651.936301179677 1.0779002235495243 1.0554360516334953 1.0683252320455758 1.147309725658801 1.1962586673937827 0.8902846752435302 0.9471682928383081 1.0002834685211088 1.0270490383043107 1.0 11.834445886026487 -6.763831116029443 24.999999993874365 0.9713630175861593 1.1059311477415206 0.6353573921980469 0.05151453632069156 46.327431484455595 484239.0008811493 0.01946385224720313 0.017978038697312407 1.7225382877317354e-07 6.763831116029443 0.1345681301553613 SSSSS(ph)QESLNRPFSSK ddPTM_A459_Selumetinib_30min_R2 3 SSSSSQESLNRPFSSK 16 1 E3W994;J3KR49;O75122;A0A0U1RQI6;B3KR06;E7ENG2;O75122-2;E7ERI8;E7EW49;O75122-3 E3W994;E7ERI8 CLASP2 CLIP-associating protein 2 1 S(0.002)S(0.002)S(0.008)S(0.051)S(0.538)QES(0.399)LNRPFS(0.001)SK;SSSS(0.003)S(0.997)QESLNRPFSSK;SSS(0.002)S(0.03)S(0.968)QESLNRPFSSK 180.27 4.859e-06 103675000.0 255263.0 201918.0 263392.0 307763.0 296001.0 190118.0 221699.0 238201.0 183683.0 245328.0 True False 241076.50435875173 217404.46133129924 246445.64547952678 265845.1484792125 258814.7080974851 216305.02878062808 232008.44278823424 238894.12547370177 220424.7325318338 238244.7432013067 1.0118859334287695 0.9125257431077994 1.0344221751465494 1.115848958121962 1.0863396380536197 0.9079110240760255 0.9738239747527061 1.0027256940223288 0.9252029218776268 1.0 17.8620848562905 -6.761994749474892 24.999873807406594 0.9628462886766187 1.0303257847006178 0.27671364054106995 0.056755282351495094 24.214960307388743 1090010.383180947 0.021519828643763318 0.020134105868551324 1.729837272442201e-07 6.761994749474892 0.06747949602399905 SSSSS(ph)QESLNRPLSAK ddPTM_A459_Selumetinib_30min_R1 2 SSSSSQESLNRPLSAK 16 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.014)S(0.014)S(0.073)S(0.393)S(0.498)QES(0.007)LNRPLSAK;SSSS(0.037)S(0.963)QESLNRPLSAK 185.99 3.7535e-06 18227500.0 2424.19 2787.5 3158.8 3689.0 3156.1000000000004 2324.1499999999996 2871.67 2512.0699999999997 1077.62 1972.26 True False 2480.6689103473886 2461.1382041264083 2729.8523100463913 3044.7854011063737 2870.6313122547135 2300.7711611593586 2655.0576199052207 2445.4417432466485 1828.64243374924 2225.4187824392498 1.1146975705976396 1.1059213769323857 1.2266690348745233 1.3681853613947788 1.28992859002846 1.0338598646307444 1.1930597696290897 1.098868115315462 0.8217071088727359 1.0 11.119861134672568 -8.060239870927253 4.0011100985836245 0.9140085658905559 1.1916088858907932 0.5561050013331779 0.09845689060974328 0.1814987188429084 5.6694826958558755 0.07706204589609823 0.027834314308507125 8.70482669364441e-09 8.060239870927253 0.27760032000023727 SSSSS(ph)QESLNRPLSAK ddPTM_A459_Selumetinib_30min_R2 2 SSSSSQESLNRPLSAK 16 1 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 SSSS(0.117)S(0.882)QESLNRPLSAK;S(0.001)SSS(0.044)S(0.922)QES(0.032)LNRPLSAK 214.54 5.524700000000001e-08 16450900.0 91347.0 75852.0 96349.0 99561.0 96244.0 67349.0 68996.0 77922.0 66349.0 83183.0 True False 86270.29943101392 81669.60449737858 90150.01023685941 86000.62004769519 84152.96828772321 76625.71341664917 72204.45071298027 78148.74011931854 79620.65394595373 80781.29065461052 1.0679490106177216 1.0109965294633152 1.115976354256407 1.0646106214791802 1.0417383481470812 0.9485576771021277 0.8938264061872755 0.96741138308191 0.9856323574524302 1.0 16.301733575926313 -6.691867761469089 4.239318844078135 0.9526820383996359 1.0632440052092904 0.6703351709461532 0.03556004816838201 0.12874611832604413 4.501837576152083 0.012548029323362435 0.012277517120657057 2.0329759385016705e-07 6.691867761469089 0.11056196680965447 SSSSSAAAS(ph)TPPPGPPAPADPLGYLPLHGGYQYK ddPTM_A459_Selumetinib_30min_R2 1 SSSSSAAASTPPPGPPAPADPLGYLPLHGGYQYK 34 0 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 S(0.008)S(0.008)S(0.021)S(0.021)S(0.06)AAAS(0.47)T(0.41)PPPGPPAPADPLGY(0.001)LPLHGGYQYK 60.23 0.00034584 4464900.0 8662.2 7911.0 7561.9 11310.0 11082.0 8446.0 9119.3 6601.1 8372.6 6888.8 True False 8180.789601534027 8517.748262125751 7075.375586774199 9769.558489161764 9689.780085662998 9609.359834845653 9543.365519550143 6620.308108129066 10047.353949990093 6689.90244474809 1.2228563374577097 1.2732245847340589 1.0576201439721629 1.460343939220124 1.4484187423794144 1.4363976028364187 1.4265328378655455 0.9895971074027157 1.501868529918216 1.0 12.7077694576358 -10.88905220853356 3.714961589706314 0.9986307047746605 1.3100798363795927 0.23710252616406324 0.16835339632888527 124083230.82972433 131334163.1858669 1705294.2796069148 0.04245053226085418 1.291064059546219e-11 10.88905220853356 0.31144913160493215 SSSSSAS(ph)PSSPSSR ddPTM_A459_Selumetinib_30min_R2 2 SSSSSASPSSPSSR 14 0 E9PK91;Q9NYF8-3;H0YF63;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSS(0.006)S(0.001)S(0.022)AS(0.507)PS(0.383)S(0.079)PS(0.001)SR;SSSS(0.013)S(0.12)AS(0.686)PS(0.09)S(0.09)PS(0.001)SR 80.37100000000002 0.034113 2928190.0 672.21 582.61 942.87 429.31 1601.25 741.72 736.83 1041.83 1387.08 2668.38 True False 634.8512592698377 627.2943136135863 882.2067707192363 370.83723739894214 1400.0866596433732 843.8851973362204 771.0940550009461 1044.861552815759 1664.5347582533805 2591.336936116145 0.24498985462745063 0.24207362032733773 0.34044464014836834 0.14310653015842362 0.540295104094723 0.32565629948570957 0.2975661112431986 0.40321331365799973 0.6423459392926953 1.0 11.339480897424556 -8.536714501978082 1.3605314072932222 1.0004248480106146 0.30294403719367285 0.8397107453642939 0.09556194538055864 0.1747740264125083 0.7112010932479257 0.0912761195940607 0.02754427268520096 2.9059323386388365e-09 8.536714501978082 -0.6974808108169417 down SSSSSASPSS(ph)PSSR ddPTM_A459_Selumetinib_30min_R1 3 SSSSSASPSSPSSR 14 0 E9PK91;Q9NYF8-3;H0YF63;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSSS(0.005)S(0.001)AS(0.04)PS(0.174)S(0.775)PS(0.005)SR;SSSSSAS(0.001)PS(0.042)S(0.916)PS(0.031)S(0.009)R;SSS(0.001)S(0.001)S(0.152)AS(0.106)PS(0.106)S(0.633)PS(0.001)SR 128.21 0.0011527999999999998 3988300.0 1402.58 2093.9700000000003 1820.9900000000002 1905.15 1009.0300000000001 1273.88 967.85 1469.43 1913.7 1518.7399999999998 True False 1435.2573850544052 1848.8070189397586 1573.7095599820734 1572.4513165946885 917.7634146587152 1261.0659237904977 894.8442952794945 1430.4559430186744 3247.409128882095 1713.685072780357 0.8375269224500984 1.0788487618324025 0.9183189986178842 0.9175847660524202 0.5355496346651932 0.735879622120119 0.522175462395585 0.8347250995761086 1.8949859460544625 1.0 10.742886291613495 -8.153399860423626 8.402586758898615 1.444327614722235 0.7927977800858729 0.5067106623922168 0.25668863669669745 0.22419240454158887 15.444423161062387 0.17167499564162172 0.06451145545613209 7.024252902144546e-09 8.153399860423626 -0.6515298346363622 SSSSSASPSS(ph)PSSR ddPTM_A459_Selumetinib_30min_R2 5 SSSSSASPSSPSSR 14 0 E9PK91;Q9NYF8-3;H0YF63;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSSSSASPSS(0.995)PS(0.005)SR;SSSSSASPS(0.022)S(0.955)PS(0.022)SR;SSSSSASPS(0.047)S(0.953)PSSR;SSSSS(0.002)AS(0.009)PS(0.083)S(0.814)PS(0.083)S(0.009)R;SSSSSASPS(0.005)S(0.948)PS(0.043)S(0.004)R 295.44 2.9230999999999993e-67 668583800.0 763227.1 655987.7 667036.6000000001 883146.4999999999 948615.5 628033.2000000001 876415.7000000001 989048.1000000001 825807.8 1134887.2999999998 True False 720809.9932221576 706299.8472570946 624120.1913705379 762860.4231873106 829441.94015983 714539.0725822389 917170.7666347646 991926.0662252738 990992.4349978054 1102120.1548576748 0.6540212426432227 0.6408555765394786 0.5662905161653043 0.6921753674723647 0.752587579951246 0.6483313724305431 0.8321876363409813 0.9000162657885235 0.8991691428833182 1.0 20.071850086670352 -7.556991696032266 0.6799405246347999 0.9955561160086659 0.6267529370021456 0.8806643774281006 0.046583027949676975 0.23181662750949464 0.20854601641599735 0.0436854073673789 0.02439782848508789 2.7733731326818907e-08 7.556991696032266 -0.36880317900652027 SSSSSASPSSPS(ph)SREEK ddPTM_A459_Selumetinib_30min_R1 1 SSSSSASPSSPSSREEK 17 1 E9PK91;Q9NYF8-3;H0YF63;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 SSSSSASPS(0.033)S(0.091)PS(0.438)S(0.438)REEK 90.755 0.004843899999999999 10392000.0 872.73 677.09 3844.2 4382.5 2041.4 1660.2 1242.4 982.7 659.48 778.59 True False 893.062910963033 597.815988029399 3322.178754679095 3617.1786447136556 1856.7557304384438 1643.4998953409931 1148.6847677380222 956.6356037405334 1119.0893934865248 878.5296106088322 1.016542755279619 0.6804733509381715 3.7815216636543223 4.117309878954342 2.113481102989447 1.8707393302338744 1.307508311463707 1.0889053620828701 1.2738209161908405 1.0 9.778947102483725 -7.056170674324583 2.203551617265826 1.1555513522240197 2.4241208534569005 0.23780370620164382 0.9925636464770019 0.5302782742006077 5.109352479066135 0.49731656477715536 0.37565094379034203 8.786771357476994e-08 7.056170674324583 1.2685695012328808 SSSSSGVPYS(ph)PAIPNK ddPTM_A459_Selumetinib_30min_R1 4 SSSSSGVPYSPAIPNK 16 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-4;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 1 SSSSSGVPY(0.001)S(0.999)PAIPNK;SSSSSGVPYS(1)PAIPNK;SSSSSGVPYS(1)PAIPNK;SSSSSGVPY(0.013)S(0.987)PAIPNK 187.75 8.7833e-07 183901000.0 44237.6 49614.1 50540.4 53795.4 49086.1 42118.8 46958.0 43050.8 25187.800000000003 39465.100000000006 True False 45268.25000861465 43805.25810703068 43677.291278545206 44401.04325472422 44646.27092185481 41695.12311281062 43415.92025389728 41908.95293529353 42741.856955874195 44530.830007627395 1.0165597632215915 0.9837063018930382 0.9808326337295759 0.9970854629729349 1.0025923818219342 0.9363203673874693 0.9749631939593503 0.9411222051804383 0.9598261911703245 1.0 15.44251688189232 -6.745216716294942 24.999860476332 0.9595488262969452 0.9946641181259811 0.4355510471625027 0.019006852101272415 215.4361439165111 331996.2097966654 0.005952154552847916 0.0059353282677138035 1.7979734886025891e-07 6.745216716294942 0.035115291829035944 SSSSSGVPYS(ph)PAIPNK ddPTM_A459_Selumetinib_30min_R2 4 SSSSSGVPYSPAIPNK 16 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-4;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 1 SSSSS(0.001)GVPYS(0.999)PAIPNK;SSSSSGVPYS(1)PAIPNK;SSSSSGVPYS(1)PAIPNK;SSSSSGVPY(0.241)S(0.758)PAIPNK 132.65 0.00060163 270333900.0 698767.0 568245.0 643201.0 711675.0 718370.0 625609.0 639800.0 585848.0 456160.0 604816.0 True False 659932.3275259313 611827.5643043424 601818.1479242983 614743.6372921487 628121.9382907168 711780.9610369357 669551.9677396491 587552.720687642 547404.7461753204 587353.3905793115 1.123569452582941 1.0416685663479217 1.0246270091855945 1.0466333337853415 1.0694105939717058 1.211844474643962 1.1399473953479087 1.0003393699798582 0.9319853344771033 1.0 19.163869259595565 -7.9198738592310125 5.668574130990019 0.9659105116017426 1.090674254539465 0.4949611190804666 0.05453187551487327 0.18680654767696328 9.854761368980158 0.034667897494191816 0.016197511524191816 1.2026136828643609e-08 7.9198738592310125 0.12476374293772241 SSSSSGVPYS(ph)PAIPNKR ddPTM_A459_Selumetinib_30min_R1 2 SSSSSGVPYSPAIPNKR 17 1 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-4;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 1 SSS(0.006)S(0.023)S(0.005)GVPYS(0.965)PAIPNKR;SSSSSGVPY(0.003)S(0.997)PAIPNKR 216.77 1.81e-11 83775000.0 5807.6 6917.1 7117.0 7211.9 7247.8 6059.9 6384.7 5649.0 3468.5 5850.6 True False 5942.905780377562 6107.242716327454 6150.550490882661 5952.4770491295885 6592.237769703019 5998.942907948968 5903.0969386485385 5499.170169461965 5885.791170783057 6601.581499669963 0.9002245568996868 0.9251181276233245 0.9316783396812035 0.9016744017213413 0.9985846224927449 0.9087129967643174 0.8941943591764573 0.8330079950897961 0.8915729012930174 1.0 12.68859596798352 -6.994003863337945 24.97567749993392 0.8923029275473277 0.9318804279227372 0.047874229410000635 0.04639868121978643 310.2084684311066 1292101.3209798823 0.015920041905088375 0.014003003126423899 1.0139023663614157e-07 6.994003863337945 0.039577500375409524 SSSSSGVPYS(ph)PAIPNKR ddPTM_A459_Selumetinib_30min_R2 3 SSSSSGVPYSPAIPNKR 17 1 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-4;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 1 SSSSSGVPYS(1)PAIPNKR;SSSSSGVPYS(1)PAIPNKR;SSSSSGVPYS(1)PAIPNKR 129.06 0.00049668 181203000.0 372759.0 339625.0 345854.0 403421.0 392345.0 336891.0 364333.0 337429.0 263655.0 333946.0 True False 352042.54705250595 365673.14543350437 323602.130177364 348474.3638599577 343055.113491197 383294.6772579907 381275.2064121434 338410.86252562207 316393.367136211 324304.1112840907 1.0855321742872275 1.127562472105617 0.9978354233501784 1.0745295903902183 1.0578191936354469 1.1818989150039614 1.1756718251349765 1.0434985273102932 0.9756070186204028 1.0 18.30698778775126 -7.997753270077843 24.95574697797089 0.9950532451028896 1.0986201749819735 0.4333077754027137 0.05165900334954189 67.98793164789798 755184.8240825817 0.031207555698021142 0.014843163069727753 1.0051866913802695e-08 7.997753270077843 0.10356692987908389 SSSSSPTSPGS(ph)FR ddPTM_A459_Selumetinib_30min_R1 1 SSSSSPTSPGSFR 13 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 SSSSSPTSPGS(1)FR 122.52 0.0019473 0.0 1183.1 1648.5 1658.3 1453.9 1838.2 1337.5 1693.4 1501.1 735.39 1108.6 True False 1210.6639280881425 1455.4928536331422 1433.111968389872 1200.0036580830993 1671.9351345605687 1324.0459643528352 1565.6654746358388 1461.2859517400163 1247.9031192394862 1250.8996086784457 0.9678346045428765 1.1635568862083552 1.145665054531379 0.9593125217705383 1.3365861840239441 1.0584750008449257 1.2516315967913187 1.1681880317189004 0.9976045324355602 1.0 10.28875029489048 -2.3308032997798542 21.136946726206794 1.1174994029278953 0.31116955811189295 0.0 0.12270362945434495 0.0 0.0 0.02652706166590484 0.0 0.004668707870831429 2.3308032997798542 -0.8063298448160023 SSSSSPTSPGS(ph)FR ddPTM_A459_Selumetinib_30min_R2 2 SSSSSPTSPGSFR 13 0 G5E9L9;Q8N568-2;Q8N568;A0A0U1RR70;Q8N568-3 G5E9L9 DCLK2 Serine/threonine-protein kinase DCLK2 1 SSSSSPTS(0.002)PGS(0.998)FR;SSSSSPTS(0.001)PGS(0.998)FR 111.72 0.0051562 7797600.0 27136.0 25809.0 25934.0 29802.0 33314.0 24286.0 23580.0 28305.0 20948.4 30833.0 True False 25627.889754014817 27788.46731098514 24265.434674804226 25742.91618868249 29128.797489061253 27631.17605364212 24676.5167228836 28387.362863855 25138.66534720068 29942.771176245176 0.8558957219813532 0.9280526223648553 0.8103937518667272 0.8597372647026538 0.9728156862171233 0.9227995595665862 0.8241226764762671 0.9480539625662923 0.8395570737001193 1.0 14.869920127238924 SSSSSSQPEHSAMLVS(ph)TAASPSLIK ddPTM_A459_Selumetinib_30min_R2 1 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SSSSSSQPEHS(0.002)AMLVS(0.349)T(0.349)AAS(0.227)PS(0.073)LIK 58.087 0.018248 9796000.0 31817.0 30833.0 44529.0 62577.0 59780.0 44371.0 39192.0 42719.0 43423.0 50981.0 True False 30048.738513542507 33197.791956279005 41664.05261950943 54053.904648653894 52269.90196001932 50482.702490165335 41014.50565747471 42843.305217488836 52108.81333999235 49509.0460654544 0.6069343059814964 0.6705399233988313 0.8415442415195529 1.0917985488387492 1.0557646756294774 1.0196662327814536 0.8284244782913143 0.865363173446061 1.0525109546869653 1.0 15.595404531436944 -5.37762133430394 2.8267603588110166 0.9792462821128185 0.6276866782932694 0.7454924909219278 0.08084435828050403 0.14682627035671225 2.2281883499338506 0.02466089469463476 0.06346219670951656 4.191588746451957e-06 5.37762133430394 -0.3515596038195491 SSSSSSQPEHSAMLVST(ph)AASPSLIK ddPTM_A459_Selumetinib_30min_R1 1 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SSSSSSQPEHSAMLVS(0.141)T(0.447)AAS(0.332)PS(0.079)LIK 84.93799999999997 0.00013945 5551000.0 1737.5 1882.6 1799.2 2011.7 2867.8 1823.7 2838.3 1925.7 434.72 1251.7 True False 1777.9803694135298 1662.1843168030043 1554.878522298172 1660.3943592859002 2608.4079963512145 1805.3552337871138 2624.204745871562 1874.6241804448398 737.6880893074277 1412.3678875904852 1.2588649069661189 1.176877732358181 1.100901922197347 1.1756103872614598 1.8468332643849519 1.2782471547601306 1.8580178499728448 1.3272917041769965 0.52230590612332 1.0 10.4639002093 -8.192989778496742 7.290558387986978 0.7640971803667137 1.3852645681493676 0.44854187966426107 0.2736258789584579 0.22669886089892063 21.044634937734966 0.1948656086803786 0.0724063949318197 6.412246681950684e-09 8.192989778496742 0.6211673877826539 SSSSSSQPEHSAMLVST(ph)AASPSLIK ddPTM_A459_Selumetinib_30min_R2 3 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SSSSSSQPEHSAMLVS(0.078)T(0.671)AAS(0.183)PS(0.069)LIK;SSSSSS(0.003)QPEHS(0.019)AMLVS(0.04)T(0.715)AAS(0.182)PS(0.04)LIK;SSSSSSQPEHSAMLVS(0.023)T(0.552)AAS(0.328)PS(0.097)LIK 124.98 1.0309e-07 44107900.0 126688.0 97306.5 195057.6 237019.0 257434.9 152568.8 136764.9 171181.9 182204.1 224431.0 True False 119647.18813224602 104769.59566028795 182507.80637865726 204736.60331941894 225093.62636479395 173583.7673183281 143124.73884450796 171680.0109883107 218650.0112079147 217951.09388823286 0.5489634669766884 0.48070231624538057 0.8373796300937529 0.9393694689342077 1.032771262346698 0.7964344854692186 0.6566828194856572 0.7876996987055713 1.003206762155735 1.0 17.733644918978314 -5.2951038156249 5.855931837369343 0.8718435960193955 0.5137873010575275 0.6297519538304659 0.112408910575598 0.11845928569085327 12.526714177907014 0.03202925182223784 0.07086274949139171 5.068695295146323e-06 5.2951038156249 -0.3580562949618681 SSSSSSQPEHSAMLVSTAAS(ph)PSLIK ddPTM_A459_Selumetinib_30min_R1 2 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SSSSSSQPEHSAMLVS(0.031)T(0.122)AAS(0.693)PS(0.153)LIK;SSSSSSQPEHSAMLVS(0.011)T(0.013)AAS(0.781)PS(0.194)LIK 114.13 6.0648e-08 94945000.0 6176.5 7595.6 7968.0 8863.6 10477.6 7577.9 9689.2 7485.799999999999 1904.25 5007.1 True False 6320.400432623116 6706.30362090136 6885.989365091061 7315.738650378537 9529.902929970525 7501.673206182687 8958.335843180326 7287.252266694699 3231.373169082786 5649.810058284186 1.1186925520364457 1.1869962975247392 1.2188001532890993 1.2948645308264193 1.686765188857464 1.3277744081295542 1.5855994716220458 1.2898225235040546 0.5719436823092305 1.0 12.463986650848726 -8.180438104731367 6.610471419208334 0.7899491655487749 1.3501760137084615 0.573766611428209 0.19064327135241624 0.16116006359732693 10.788431416530313 0.1368055856385454 0.050532581620187776 6.600272940717729e-09 8.180438104731367 0.5602268481596866 SSSSSSQPEHSAMLVSTAAS(ph)PSLIK ddPTM_A459_Selumetinib_30min_R2 1 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SSSS(0.001)SS(0.001)QPEHS(0.008)AMLVS(0.192)T(0.157)AAS(0.484)PS(0.157)LIK 58.89100000000001 0.005802399999999999 36075000.0 58188.0 63208.0 92629.0 127330.0 142140.0 91254.0 76949.0 103590.0 98967.0 134430.0 True False 54954.14390501969 68055.85035424665 86669.3509868296 109987.43434349829 124283.10245227726 103823.41017866496 80527.28097155085 103891.42974975237 118763.1653690217 130548.65660891352 0.4209476017026097 0.5213064011690487 0.663885429679037 0.8425014642087756 0.952005985205914 0.7952851670445774 0.6168373008447539 0.7958061955473155 0.9097233817181454 1.0 16.994228086330153 -5.381533586975538 1.9778944673334264 0.8290390490455534 0.4397831437116323 0.6879671706576449 0.10104532788785246 0.22609666439174736 1.6524762973587417 0.03088521728624317 0.09994291351095749 4.1539992426997195e-06 5.381533586975538 -0.38925590533392107 SSSSSSQPEHSAMLVSTAASPS(ph)LIK ddPTM_A459_Selumetinib_30min_R2 1 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 SSSSSSQPEHSAMLVS(0.02)T(0.363)AAS(0.216)PS(0.401)LIK 92.377 5.3463e-05 7863200.0 16350.0 15433.0 20304.0 28426.0 30701.0 22545.0 16278.0 18495.0 19369.0 24891.0 True False 15441.33245423578 16616.66147508365 18997.662745323705 24554.329762414873 26844.06590957767 25650.369106866598 17034.95925424508 18548.817387987918 23243.341215077522 24172.33215541526 0.638801930858645 0.68742483630654 0.7859259347910174 1.0158030927485016 1.1105285885112193 1.0611458150561701 0.704729653089298 0.7673573765546854 0.9615680053391282 1.0 14.561069051111305 -5.509329009417593 3.3768994147963918 0.9372792845553269 0.6679551637431671 0.48037132227337775 0.11900133865240602 0.241865755001454 5.72752977992129 0.03770616244700476 0.07956266138260833 3.0950736691286786e-06 5.509329009417593 -0.26932412081215984 SSSSTPTS(ph)PKPLLQSPK ddPTM_A459_Selumetinib_30min_R2 1 SSSSTPTSPKPLLQSPK 17 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(0.001)S(0.001)S(0.006)S(0.007)T(0.033)PT(0.163)S(0.788)PKPLLQSPK 71.872 0.015786 12219000.0 50553.0 30257.0 44940.0 37085.0 42916.0 32266.0 55488.0 66601.0 47608.0 43689.0 True False 47743.46663969309 32577.614608410906 42048.6093269724 32033.959024806707 37524.50840609213 36710.34861841462 58068.30194738608 66794.79788361085 57130.930278662316 42427.585052345705 1.1252930512257258 0.7678404172242601 0.9910677045392582 0.7550266880682533 0.8844365843541572 0.8652471870157739 1.3686449953666557 1.574324765390293 1.3465515467867457 1.0 15.372714943349974 -7.263336015075538 24.46448851709184 1.3702407609548943 0.8893230010131936 0.602403617525592 0.16695002963915687 74.18155732048179 956846.1188526037 0.0637707733219429 0.04547581003157269 5.453357697387781e-08 7.263336015075538 -0.4809177599417007 SSSSTPTSPKPLLQS(ph)PKPSLAAR ddPTM_A459_Selumetinib_30min_R2 1 SSSSTPTSPKPLLQSPKPSLAAR 23 2 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 S(0.007)S(0.007)S(0.013)S(0.056)T(0.056)PT(0.154)S(0.154)PKPLLQS(0.441)PKPS(0.111)LAAR 42.052 0.039688 15725000.0 137420.0 131190.0 126570.0 146350.0 121790.0 98612.0 96787.0 69926.0 43360.0 72199.0 True False 129782.74653584606 141251.8511576639 118426.62399899642 126416.87753216829 106489.6513835856 112194.90788939131 101287.78727980214 70129.47308312757 52033.21157962526 70114.42727446966 1.8510134302003072 2.014590386721979 1.6890478693551045 1.8030080604851448 1.5187979924120556 1.600168642185346 1.444606926379094 1.0002145893397802 0.7421184712232798 1.0 16.097423714166872 -7.462324403503228 0.9208382875586284 0.8207595744061814 1.828979798289943 0.8865731314154683 0.13437306406016888 0.1842640919386727 0.29155071605157873 0.11471157580611281 0.057170136516554455 3.448860247300831e-08 7.462324403503228 1.0082202238837614 SSSSVGS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 1 SSSSVGSPTR 10 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 SSS(0.001)S(0.001)VGS(0.941)PT(0.057)R 87.568 0.03942 0.0 325.04 298.26 305.66 238.73 40.553 200.01 132.51 411.94 164.52 319.25 True False 332.61279958225833 263.3395805426877 264.1530508701973 197.0402870171115 36.88498831021367 197.9980809945499 122.51466401558697 401.0140130302991 279.17842393461984 360.2288472583383 0.9233374898033219 0.73103412607551 0.7332923303634254 0.5469864185413333 0.1023932108462196 0.5496452671724967 0.34010231259387597 1.1132201545833216 0.7750029628649004 1.0 8.492769907193592 -7.766682205826523 24.999796817273022 0.958083691689307 0.5555278738237803 0.3996162751417387 0.22558290983465434 146.48975580249785 698501.9860218455 0.1281478259533894 0.06445058842566818 1.7112670735234597e-08 7.766682205826523 -0.40255581786552663 SSSSVGS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 3 SSSSVGSPTR 10 0 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 SSSSVGS(0.999)PT(0.001)R;SSSSVGS(0.999)PT(0.001)R;SSSSVGS(0.999)PTR 139.32 0.00154 111072000.0 49867.0 40779.8 45285.2 47964.6 44464.299999999996 26685.1 55044.4 69066.0 46750.9 66207.0 True False 47095.59177341747 43907.47953227601 42371.599534797715 41431.73873644988 38878.297118114504 30360.730301780688 57604.073668409415 69266.97062550818 56102.386329287416 64295.431883555466 0.7324873695336804 0.6829020079030843 0.6590141522268069 0.6443963050358897 0.604682105386996 0.47220664691648034 0.8959279373491934 1.077323358694543 0.8725718870804638 1.0 15.972428618921407 -7.433866623946448 5.739631545164904 0.9826002416327428 0.636488126858523 0.810855625563656 0.07858267227557451 0.09497352834129995 4.831210680188065 0.03431669087890818 0.022700216880491737 3.68242046987925e-08 7.433866623946448 -0.3461121147742199 SSSSVSSQGSVASST(ph)GSPASIR ddPTM_A459_Selumetinib_30min_R2 1 SSSSVSSQGSVASSTGSPASIR 22 0 A0A087WXK8;Q9H4H8-2;Q9H4H8 A0A087WXK8 FAM83D Protein FAM83D 1 SSSSVSSQGSVAS(0.011)S(0.128)T(0.43)GS(0.43)PASIR 306.19 1.022999999999999e-202 0.0 27026.0 21511.0 23700.0 23192.0 23382.0 21595.0 21368.0 22004.0 20686.0 22654.0 True False 25524.003113649935 23160.824531233335 22175.167802608936 20033.20959156849 20444.54412226782 24569.515230107965 22361.65433988875 22068.027997041714 24823.77801513209 21999.920157839268 1.1601861702463918 1.0527685721159492 1.0079658309444919 0.9106037407335783 0.929300832711558 1.1168001999022288 1.0164425224934548 1.0030958221081625 1.1283576411656473 1.0 14.425210667476732 -10.096660668995728 15.395584259023122 1.0000130790310542 1.0298100446551122 0.013270137246565006 0.07777255219816172 0.0 0.0 0.07860336073386054 0.019064115225543223 8.004594405226584e-11 10.096660668995728 0.02979696562405798 SSSTGSSSSTGGGGQESQPS(ph)PLALLAATCSR ddPTM_A459_Selumetinib_30min_R1 2 SSSTGSSSSTGGGGQESQPSPLALLAATCSR 31 0 P08047;H3BVI2;P08047-2 P08047 SP1 Transcription factor Sp1 1 SSSTGSSSSTGGGGQES(0.147)QPS(0.853)PLALLAATCSR;SSSTGSSSSTGGGGQES(0.037)QPS(0.963)PLALLAATCSR 142.78 5.953800000000001e-19 22909000.0 1095.48 1198.27 1409.8 1595.05 1322.6100000000001 1487.77 1792.17 1565.02 856.77 1077.42 True False 1121.0025525669841 1057.9759913393898 1218.3569034770796 1316.504460296752 1202.9801590257616 1472.804384587079 1656.9851740156562 1523.5105856985954 1453.8761139950414 1215.7173519595272 0.9220914308413226 0.8702483267464387 1.002171188486615 1.0829034052814772 0.9895228994525451 1.211469411218958 1.3629690909197614 1.25317828460946 1.1958997802010831 1.0 10.247592133241758 -6.7629546120476665 4.60602355050481 1.2329361316306255 0.9730120003915489 0.5685246169035022 0.09952008507163874 0.13581730950879722 7.198333136747795 0.03548631956684031 0.03316100080985284 1.7260182680820507e-07 6.7629546120476665 -0.25992413123907665 SSSTGSSSSTGGGGQESQPS(ph)PLALLAATCSR ddPTM_A459_Selumetinib_30min_R2 4 SSSTGSSSSTGGGGQESQPSPLALLAATCSR 31 0 P08047;H3BVI2;P08047-2 P08047 SP1 Transcription factor Sp1 1 SSSTGSSSSTGGGGQES(0.142)QPS(0.854)PLALLAAT(0.002)CSR;SSSTGSSSSTGGGGQESQPS(1)PLALLAATCSR;SSSTGSSSSTGGGGQES(0.003)QPS(0.996)PLALLAAT(0.001)CSR;SSSTGSSSSTGGGGQESQPS(1)PLALLAATCSR 154.48 4.7848999999999985e-21 18822700.0 46790.2 48189.0 52645.3 55817.0 66511.8 42566.5 44288.200000000004 43107.8 39518.899999999994 54449.100000000006 True False 44189.788000011205 51884.941347943095 49258.15871386868 48214.62831030434 58155.99306096375 48429.648994785384 46347.68905540346 43233.236561119564 47423.7842503241 52877.01300724843 0.8357088550738224 0.9812381297111215 0.9315609167846967 0.9118258685242873 1.0998350654374458 0.9158922987602685 0.8765186688788581 0.8176187364288734 0.8968695762717005 1.0 15.690353061664663 -6.995722922456099 24.996020484877672 0.8845036002747424 0.9560429279597124 0.09467334904401825 0.07508359551753327 225.49271122723567 1317808.5362733672 0.026261846576571043 0.023071459546715405 1.0098969894358231e-07 6.995722922456099 0.07153932768496996 SSSTSSSTVTSSAGSEQQNQS(ph)SSGSESTDKGSSR ddPTM_A459_Selumetinib_30min_R1 1 SSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSR 34 1 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 SSSTSSSTVTSSAGSEQQNQS(0.332)S(0.332)S(0.332)GS(0.003)ESTDKGSSR 130.71 2.1067e-25 4011900.0 252.64 359.62 258.5 427.2 363.51 319.14 310.07 431.48 121.49 210.87 True False 258.5260204481348 317.5155232171977 223.39711983886016 352.5975395371758 330.63058468290313 315.92974135593556 286.6811702612107 420.03574875543416 206.15965672147448 237.9372185477395 1.0865303966569835 1.3344508486531361 0.9388910284921986 1.4818931720277757 1.3895706888603716 1.3277861415890584 1.2048605594828001 1.7653217572229398 0.8664456026668682 1.0 7.894437148021592 -4.7515994083308515 24.046551109280525 1.2823744582012626 1.0865297488833827 0.029205434592052937 0.25807604582459626 864.3178032474054 2111943.521005138 0.06032684008463024 0.7563383790509924 1.7717424537076964e-05 4.7515994083308515 -0.1958447093178799 SSSTSSSTVTSSAGSEQQNQS(ph)SSGSESTDKGSSR ddPTM_A459_Selumetinib_30min_R2 1 SSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSR 34 1 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 SSSTSSSTVTSSAGSEQQNQS(0.451)S(0.451)S(0.096)GS(0.001)ESTDKGSSR 135.03 7.9308e-26 3956800.0 10140.0 9714.5 12057.0 9948.4 12057.0 9365.6 7602.1 8152.7 5233.2 9481.5 True False 9576.459393636143 10459.570912959247 11281.265746669029 8593.410758052778 10542.291869052402 10655.626387548002 7955.612713275374 8176.423007247863 6279.9862278250675 9207.744459104493 1.0400440016737291 1.1359536485199657 1.2251931834961238 0.9332807612352588 1.144937494288118 1.1572461024384602 0.8640131954801342 0.8879941275046058 0.6820330707174983 1.0 13.168632079828752 -7.271698004503627 21.93801764029533 0.8491761159449915 1.106787754883878 0.5810264414412143 0.1028800131996392 94.4009611431525 201872.82720532047 0.04162806421727979 0.028520349787122347 5.3493620886251526e-08 7.271698004503627 0.2576116389388865 SSSTSSSTVTSSAGSEQQNQSSS(ph)GSESTDKGSSR ddPTM_A459_Selumetinib_30min_R2 1 SSSTSSSTVTSSAGSEQQNQSSSGSESTDKGSSR 34 1 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 SSSTSSSTVTSSAGSEQQNQS(0.326)S(0.326)S(0.346)GS(0.002)ESTDKGSSR 133.27 1.3080999999999998e-25 5816200.0 7483.8 7347.2 8260.0 8582.1 9370.5 6524.7 6382.8 6724.9 3530.5 9784.6 True False 7067.880356025063 7910.706615028483 7728.56059280801 7413.203175051739 8193.294016667129 7423.418199670543 6679.612847278257 6744.468345632876 4236.6986504120605 9502.093174556114 0.7438235161649249 0.8325225263219994 0.8133534844199259 0.7801652792568037 0.8622620159741672 0.7812403081405613 0.7029622552180764 0.7097876459149687 0.44587003858862667 1.0 13.214029638096909 -7.240656530544032 3.14062523384206 0.6873470294768008 0.8079272102765427 0.08856585133069006 0.1285174912367363 0.48342376628939226 9.777474642269805 0.05300400968690066 0.03701975525215524 5.745706919382904e-08 7.240656530544032 0.12058018079974187 SSSVGSSSSYPIS(ph)PAVSR ddPTM_A459_Selumetinib_30min_R1 4 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 SSSVGSSSS(0.001)YPIS(0.999)PAVSR;SSSVGSSSS(0.001)YPIS(0.998)PAVSR;SSSVGSSS(0.001)SYPIS(0.999)PAVSR;SSSVGSSS(0.001)S(0.001)YPIS(0.998)PAVSR 338.97 5.2056999999999966e-163 238953000.0 8195.03 8877.75 10378.7 9479.79 9969.62 7620.24 9688.73 8790.01 5309.23 7458.150000000001 True False 8385.95825424746 7838.338902845996 8969.329546118297 7824.322634197387 9067.86963127937 7543.587304224334 8957.901295658721 8556.870380823571 9009.375539183093 8415.476201032974 0.9964924210965161 0.9314195317769259 1.0658136666131073 0.9297539969558675 1.0775230556966364 0.8963945858819471 1.0644556625992438 1.016801684944845 1.0705722794483359 1.0 13.038829195365333 SSSVGSSSSYPIS(ph)PAVSR ddPTM_A459_Selumetinib_30min_R2 4 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 SSSVGSSSSYPIS(1)PAVSR;SSSVGSSSSYPIS(1)PAVSR;SSSVGSSSSYPIS(1)PAVSR;SSSVGSSSSYPIS(1)PAVSR 261.06 1.1453e-42 324511000.0 80018.0 72419.0 93575.0 100606.0 100680.0 65492.2 83831.0 80764.2 61512.1 78847.0 True False 75570.91989743352 77973.30443621338 87554.48637675647 86903.28924496977 88031.6783093802 74513.15607100143 87729.30760797512 80999.21045076683 73816.23879167593 76570.48224089133 0.98694585283774 1.0183206655393493 1.1434495880711495 1.134945042811293 1.1496816492866253 0.9731316022874515 1.145732729382297 1.0578385832277075 0.9640299581691215 1.0 16.224500722980785 -8.149868450157285 4.82802829747764 0.9832099720061243 1.0810992513511672 0.26072171177423975 0.06396303247437063 0.3061398979424144 10.638628150060336 0.04801961729621256 0.017052150490824845 7.081602569751404e-09 8.149868450157285 0.09788927934504299 SSSVGSSSSYPISPAVSR ddPTM_A459_Selumetinib_30min_R1 1 SSSVGSSSSYPISPAVSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 203.74 1.7745e-28 0.0 1222.6 1709.8 1305.2 1297.0 1835.9 1144.1 1294.9 1270.2 743.07 878.06 False True 1251.0842012345224 1509.6158211355446 1127.9610089504072 1070.5032977053306 1669.8431691544706 1132.5913927596848 1197.224650470029 1236.510169808919 1260.9355183144792 990.7675540286814 1.262742402238886 1.5236831434347144 1.1384718891569134 1.080478759475344 1.685403566522255 1.1431454210973262 1.2083809624183262 1.2480325630174236 1.2726855186034653 1.0 9.952402813296043 -14.09960247076604 0.18095909775390367 6.275233022838648e-12 1.3467143886220987 0.20353452330263988 0.17433358716885405 188.55775844022773 2.083033273637914 68.09742192501129 0.5439150639708572 7.950556518814444e-15 14.09960247076604 1.3467143886158235 SSSVLS(ph)LEGSEK ddPTM_A459_Selumetinib_30min_R1 2 SSSVLSLEGSEK 12 0 A1L390-3;A1L390;G3V311;A1L390-2;A0A0U1RR71 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.002)SS(0.078)VLS(0.92)LEGSEK;S(0.001)S(0.001)S(0.006)VLS(0.991)LEGSEK 228.17 7.710599999999999e-10 121641000.0 5925.6 6656.5 7443.5 7850.700000000001 6803.2 6105.5 6180.7 5824.700000000001 3203.7 5418.6 True False 6063.654950789536 5877.153885477108 6432.7135842187845 6479.722620890702 6187.851761202513 6044.084213350459 5714.484822889883 5670.210034707933 5436.4449110098585 6114.130091633619 0.9917445098341707 0.9612412227733294 1.052106103044995 1.0597946925855157 1.012057589299543 0.9885436068200433 0.9346357923769731 0.9273944043923548 0.8891608175705841 1.0 12.577931533739765 -7.124982293803342 2.530720530098931 0.9304686241215822 1.0166276517631538 0.4966264605669478 0.0365962454080663 0.24418173671973653 3.049707041345471 0.016682435333142127 0.012256228801725652 7.499247831609704e-08 7.124982293803342 0.08615902764157168 SSSVLS(ph)LEGSEK ddPTM_A459_Selumetinib_30min_R2 4 SSSVLSLEGSEK 12 0 A1L390-3;A1L390;G3V311;A1L390-2;A0A0U1RR71 A1L390-3 PLEKHG3 Pleckstrin homology domain-containing family G member 3 1 S(0.001)SS(0.095)VLS(0.904)LEGSEK;S(0.004)SS(0.044)VLS(0.952)LEGSEK;S(0.02)S(0.002)S(0.232)VLS(0.747)LEGSEK;S(0.039)S(0.002)S(0.054)VLS(0.841)LEGS(0.063)EK 209.19 7.3514e-06 110535000.0 314151.0 301673.0 313302.0 321942.0 318822.0 251313.0 292445.0 275018.0 232792.0 297697.0 True False 296691.7450660931 324810.3490684181 293144.49041742523 278092.94421907293 278768.7300551567 285929.0845577273 306044.27196877386 275818.2568483194 279356.9047519402 289101.71410030423 1.026253842836627 1.1235158189194434 1.013983923719381 0.9619207727097329 0.9642583093036851 0.9890259054587405 1.0586041418716439 0.9540526513537857 0.9662927998241372 1.0 18.14121763709708 -5.472948509206385 6.570407410968218 0.9854653771629986 1.0742617405161263 0.49988232395867027 0.03559586026357907 0.1776906857262329 18.305785709140984 0.009412340415936145 0.01944863004515306 3.3655146920315686e-06 5.472948509206385 0.08879636335312768 SSSVS(ph)PSASFR ddPTM_A459_Selumetinib_30min_R2 2 SSSVSPSASFR 11 0 Q04727-4;Q04727;Q04727-3;H7C4W5;H7C4P7;Q5JSY7;Q04727-2 Q04727-4 TLE4 Transducin-like enhancer protein 4 1 SSS(0.001)VS(0.998)PS(0.001)ASFR;SSS(0.001)VS(0.982)PS(0.017)ASFR 182.71 3.4916e-05 46132000.0 100348.0 107747.0 119836.0 131364.0 143410.0 103993.0 100228.0 112060.0 105563.0 116480.0 True False 94771.05988487182 116010.84843878959 112125.88222757145 113471.99658446018 125393.55369833339 118317.09179553669 104888.80059801416 112386.07604746825 126678.54967666024 113116.91974861457 0.8378150686518544 1.0255835174490813 0.9912388215375246 1.0031390249719911 1.108530483123142 1.0459716553321883 0.9272600494348133 0.9935390417033056 1.1198903750047682 1.0 16.78745521465519 -4.760829143536003 24.957826447920283 1.0223480733892871 0.8378148549281571 0.5159585068596566 0.054054003957459976 12.469416470950044 509561.78428888443 0.013883314354305117 0.08018036851860905 1.7344862304574735e-05 4.760829143536003 -0.18453321846113002 SSSVSPSSWKS(ph)PPAS(ph)PESWK ddPTM_A459_Selumetinib_30min_R1 1 SSSVSPSSWKSPPASPESWK 20 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 2 SSS(0.002)VS(0.011)PS(0.079)S(0.111)WKS(0.833)PPAS(0.887)PES(0.076)WK 91.481 0.0030355 29252000.0 2622.9 2624.8 3107.0 3788.2 2970.1 2831.9 2481.5 2485.6 1733.9 2077.8 True False 2684.008466725035 2317.4871957635846 2685.0864655293567 3126.661983320995 2701.4549794137442 2803.4136571594736 2294.318457132888 2419.673813633326 2942.3016609545207 2344.5058694859067 1.1448077403677275 0.9884757491657521 1.1452675382374415 1.3336123504807418 1.1522491858832957 1.195737529876261 0.9785936077165703 1.0320613162567607 1.2549773064119887 1.0 11.195068175521891 -7.2372644906221435 24.798873876890358 1.0690798050741936 1.1590934135273292 0.16001299322122153 0.10499530828174752 1494.2757462327295 1532846.55882735 0.042357613211861975 0.032793301436996235 5.790759247347406e-08 7.2372644906221435 0.09001360845313555 SSSVT(ph)SIDKESR ddPTM_A459_Selumetinib_30min_R2 1 SSSVTSIDKESR 12 1 H0Y332;Q5JRH0;Q5T5C0-3;Q5T5C0-2;Q5T5C0 H0Y332 STXBP5 Syntaxin-binding protein 5 1 SSS(0.015)VT(0.904)S(0.081)IDKESR 178.22 0.0010750999999999998 4349800.0 27108.0 25846.0 26667.0 26994.0 28593.0 17751.0 19765.0 22926.0 15219.0 20426.0 True False 25601.44588192194 27828.30509201139 24951.274252834275 23317.370632752652 25000.89171533676 20196.039122465674 20684.1116636045 22992.710864396373 18263.225254389225 19836.248306878475 1.2906395143805651 1.402901630464142 1.257862568910377 1.1754929799233786 1.2603639220763019 1.0181380475794124 1.0427431308385073 1.1591259853519456 0.920699568378372 1.0 14.275851569544628 -6.275772872655274 0.5762807115982784 1.0011724391349794 1.383334206792184 0.7371040346396012 0.07468659171534649 0.5360856189091737 0.36667672101842297 0.0546376821315367 0.10914292867543571 5.299405197460205e-07 6.275772872655274 0.38216176765720467 SSSVTS(ph)IDKESR ddPTM_A459_Selumetinib_30min_R1 3 SSSVTSIDKESR 12 1 H0Y332;Q5JRH0;Q5T5C0-3;Q5T5C0-2;Q5T5C0 H0Y332 STXBP5 Syntaxin-binding protein 5 1 SSS(0.001)VT(0.054)S(0.944)IDKESR;SSS(0.002)VT(0.021)S(0.978)IDKESR;SS(0.002)S(0.07)VT(0.07)S(0.858)IDKESR 221.09 1.3280999999999998e-07 21978900.0 9818.4 10419.029999999999 12840.400000000001 12953.7 11023.84 9399.77 9629.83 10557.94 5552.66 9185.470000000001 True False 10047.149616719307 9199.165123924366 11096.744207268479 10691.579466064415 10026.735618417026 9305.216848108294 8903.444170079389 10277.909134177602 9422.458469759336 10364.514548554587 0.969379662660656 0.887563530431559 1.0706477525101266 1.0315562215651903 0.9674100577933322 0.8977957244901527 0.8590314701541949 0.9916440452689544 0.9091075540121049 1.0 13.339364924863707 -6.561759619700316 7.289142522053138 0.9268725204760334 0.9896574291494413 0.17922161723573093 0.05870183410792473 0.35314585661978515 52.49171651376125 0.020122385637355543 0.020229996438376936 2.743092042554359e-07 6.561759619700316 0.06278490867340791 SST(ph)DFSELEQPR ddPTM_A459_Selumetinib_30min_R1 1 SSTDFSELEQPR 12 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 S(0.001)S(0.001)T(0.998)DFSELEQPR 217.88 1.0636e-07 36987000.0 2910.0 2552.5 3198.9 2888.2 2816.8 3130.7 2482.6 2324.6 1748.1 2063.7 True False 2977.797338125683 2253.652113374943 2764.5069502999236 2383.8300882286317 2562.020937346431 3099.208000448164 2295.3354832472733 2262.944056635028 2966.398023827555 2328.595997140276 1.27879518035017 0.9678158496117958 1.1871990477072818 1.0237199115502167 1.1002427816988527 1.3309341784724653 0.9857164944310437 0.9718062125908169 1.2738998209524353 1.0 11.185244643626612 -11.37528978821261 2.7957171114753927 0.9553888163116091 1.1155242031948418 0.07167247179058389 0.13086756712410855 28420870.706562206 15548783.0047732 8345629.8626616215 0.03134597631996084 4.214152152254216e-12 11.37528978821261 0.1601353868832327 SST(ph)DFSELEQPR ddPTM_A459_Selumetinib_30min_R2 2 SSTDFSELEQPR 12 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 SS(0.001)T(0.999)DFSELEQPR;S(0.003)S(0.128)T(0.87)DFSELEQPR 240.65 5.3654e-13 37882000.0 88050.0 72790.0 74630.0 89286.0 77374.0 84122.0 58319.0 66078.0 63254.0 79906.0 True False 83156.53349207705 78372.75894326044 69828.38705100025 77125.09277305884 67653.58638766357 95709.04191651489 61030.94905690621 66270.27604019828 75906.56746442837 77598.9061592789 1.0716199184739874 1.0099724702612836 0.8998630329617154 0.9938940713255996 0.8718368561639047 1.2333813278252053 0.7864923885864392 0.8540104406133309 0.9781912042500078 1.0 16.2437486957543 SST(ph)GPEPPAPTPLLAER ddPTM_A459_Selumetinib_30min_R2 2 SSTGPEPPAPTPLLAER 17 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.025)S(0.109)T(0.866)GPEPPAPTPLLAER;SS(0.004)T(0.996)GPEPPAPTPLLAER 151.73 0.00077321 0.0 10610.3 10493.4 12381.3 14042.6 14808.9 11694.4 10184.8 11391.2 11115.2 10344.1 True False 10020.622002396205 11298.210038401 11584.700637740167 12129.973655163829 12948.473588754263 13305.197448806408 10658.41338079833 11424.346506085327 13338.550584636781 10045.438955800533 0.997529530216298 1.12471043705632 1.1532299074945669 1.207510563603557 1.2889903214510534 1.3245013490548956 1.061020173204462 1.1372670279867234 1.327821575873965 1.0 13.294252986479806 -4.719047300381429 1.3891064892167213 1.199965091532429 0.8944899822661553 0.2432509932306507 0.10206984209635556 2.0275524494668313 3.179187659685709 0.029652838913162984 0.9093111499804163 1.909645261752754e-05 4.719047300381429 -0.30547510926627364 SST(ph)LSQLPGDK ddPTM_A459_Selumetinib_30min_R2 1 SSTLSQLPGDK 11 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 S(0.16)S(0.16)T(0.68)LSQLPGDK 131.32 0.0052032 4449600.0 39830.0 39089.0 45837.0 45602.0 35050.0 40676.0 34385.0 38132.0 34377.0 43561.0 True False 37616.40805212304 42087.000609054936 42887.89732355215 39390.9289321622 30646.705649024374 46278.749780035745 35983.97063258491 38242.95780690755 41253.36057363417 42303.280744929674 0.8892078200490777 0.9948873909525171 1.0138196510608115 0.9311554148642114 0.7244522200018159 1.0939754308673224 0.8506189117943961 0.9040187222711141 0.9751811170952422 1.0 15.368481932514111 -4.311273682420359 0.0025502391686006965 1.8556528817753137 4.711936924431501e-08 0.01131860216819347 0.09709782367236951 1653011.497003064 573.2969057112398 204152.43049506663 213074.24402690493 4.883445188422077e-05 4.311273682420359 -1.8556528346559444 SST(ph)PEEVK ddPTM_A459_Selumetinib_30min_R2 1 SSTPEEVK 8 0 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;E9PLJ3;E9PS23 P23528 CFL1 Cofilin-1 1 S(0.023)S(0.023)T(0.955)PEEVK 125.71 0.01174 35385000.0 1007900.0 895440.0 800180.0 916460.0 870560.0 664090.0 1039200.0 1233100.0 800560.0 1133600.0 True False 951884.9529433791 964117.3687065969 748697.2899701103 791636.567018318 761192.4698948534 755562.3694911969 1087524.8591357332 1236688.1168493046 960694.3695153326 1100870.022553484 0.8646660672396802 0.8757776567212837 0.6800959919260006 0.719100848238292 0.6914462691328959 0.6863320410330178 0.98787762120473 1.1233734151292345 0.8726682985580697 1.0 20.070212712261878 -7.2928919665551915 9.555943549171674 1.0065834707968466 0.7508684009115446 0.6556614173038018 0.08615528633080471 0.31503657801918805 92.95688311955496 0.037714102772743965 0.025617761000224323 5.0945758602891265e-08 7.2928919665551915 -0.255715069885302 SST(ph)PLHSPSPIR ddPTM_A459_Selumetinib_30min_R1 2 SSTPLHSPSPIR 12 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 SS(0.002)T(0.997)PLHSPSPIR;SS(0.002)T(0.997)PLHS(0.001)PSPIR 210.44 5.900299999999999e-28 37397000.0 5931.0 6315.6 6569.0 7100.9 7793.799999999999 5427.2 6311.9 5224.3 2207.3 4204.0 True False 6069.180760282959 5576.166615957219 5676.965880934132 5860.861115401532 7088.852166107152 5372.607295503332 5835.788301260152 5085.734593081983 3745.626885186521 4743.624350427733 1.279439582886807 1.1755076296154048 1.1967570493692739 1.235523870028422 1.4943957704972886 1.1325954372881326 1.230238288310907 1.072120011489401 0.7896128800436691 1.0 12.211774051453046 -7.947247909474674 2.846504057580821 0.8958912523788044 1.2504101536178536 0.6525509761193755 0.10371135192637367 0.16411309165462662 2.602863700505253 0.07459913949677743 0.028465879817358552 1.129151174301606e-08 7.947247909474674 0.35451890123904917 SST(ph)PLPTISSSAENTR ddPTM_A459_Selumetinib_30min_R1 6 SSTPLPTISSSAENTR 16 0 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 S(0.004)S(0.004)T(0.992)PLPTISSSAENTR;S(0.016)S(0.012)T(0.972)PLPTISSSAENTR;S(0.009)S(0.009)T(0.983)PLPTISSSAENTR;S(0.01)S(0.01)T(0.981)PLPTISSSAENTR;SS(0.007)T(0.988)PLPT(0.001)IS(0.001)S(0.001)S(0.001)AENTR;S(0.005)S(0.005)T(0.989)PLPTISSSAENTR 220.52 1.8855e-10 2286564500.0 13171.76 14818.099999999999 15390.099999999999 14073.100000000002 14949.880000000001 12749.259999999998 15127.06 14101.359999999999 7191.030000000001 10761.250000000002 True False 13478.636380216609 13083.1899632522 13300.208951768056 11615.497269804857 13597.665993615694 12621.014019801894 13986.01368533413 13727.34612512731 12202.652697949008 12142.561260951596 1.110032396835551 1.0774654277697988 1.0953380152620071 0.9565936724699354 1.119835074445411 1.0394029520270094 1.151817428363385 1.1305148749195206 1.0049488271630678 1.0 13.567785144531477 SST(ph)PLPTISSSAENTR ddPTM_A459_Selumetinib_30min_R2 7 SSTPLPTISSSAENTR 16 0 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 S(0.119)S(0.068)T(0.813)PLPTISSSAENTR;S(0.009)S(0.009)T(0.982)PLPTISSSAENTR;S(0.007)S(0.007)T(0.986)PLPTISSSAENTR;S(0.01)S(0.01)T(0.972)PLPTIS(0.002)S(0.004)S(0.001)AENTR;S(0.001)S(0.198)T(0.802)PLPTISSSAENTR;S(0.009)S(0.009)T(0.981)PLPTISSSAENTR;S(0.004)S(0.004)T(0.993)PLPTISSSAENTR 239.51 4.8589e-21 2968661500.0 307610.4 203871.0 298495.4 315116.0 299181.0 205890.1 293091.5 245850.80000000002 200020.09999999998 245156.2 True False 290514.6454299974 219507.25015141448 279290.5309412183 272196.6571945798 261595.20806792463 234249.59239075918 306720.83549978974 246566.1851252092 240029.709028547 238077.90351369584 1.2202503514287082 0.9219975768930901 1.1731056381935572 1.1433091991207038 1.098779870820208 0.9839199225697296 1.2883213056441631 1.0356533785212245 1.0081981800328599 1.0 17.86107420184674 -7.981040748042105 24.997995872457466 1.0100411505695122 1.1119335133633792 0.18627334425297404 0.10015589455251844 395.9218214269539 522027.48225480365 0.05269142498932117 0.025306221523872352 1.0446222020729437e-08 7.981040748042105 0.10189236279386704 SST(ph)PLSEAK ddPTM_A459_Selumetinib_30min_R2 3 SSTPLSEAK 9 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.031)S(0.221)T(0.749)PLSEAK;S(0.001)S(0.011)T(0.988)PLSEAK;S(0.03)S(0.073)T(0.897)PLSEAK 173.24 0.0010285 94852000.0 1464920.0 1552760.0 1509530.0 1746040.0 1612850.0 1421640.0 1526030.0 1436350.0 1185550.0 1612240.0 True False 1383505.610939395 1671851.6990896715 1412408.483251994 1508226.339912998 1410229.3639380587 1617458.0056369826 1596993.4187710788 1440529.5406994566 1422693.1270347016 1565690.4420974108 0.8836393029812715 1.0678047551021939 0.9020994478065031 0.9632979159613229 0.9007076533269915 1.033063728402291 1.0199930815389882 0.9200602507157879 0.9086682071896991 1.0 20.578367570077532 SST(ph)PPGESYFGVSSLQLK ddPTM_A459_Selumetinib_30min_R1 2 SSTPPGESYFGVSSLQLK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.03)S(0.03)T(0.94)PPGESYFGVSSLQLK;S(0.003)S(0.003)T(0.994)PPGESYFGVSSLQLK 209.33 3.2214e-11 2228860000.0 12300.599999999999 13346.7 14718.8 15331.9 13618.7 11084.599999999999 13663.3 12035.900000000001 6683.9 10539.099999999999 True False 12587.180047198884 11784.062159287512 12720.067804581104 12654.471480407365 12386.890989576765 10973.09898801154 12632.666280614067 11716.668833886932 11342.090127258727 11891.896144527336 1.0584670345436475 0.9909321453930247 1.069641682872827 1.0641256303126199 1.0416245516302483 0.9227375394681169 1.062292011894809 0.9852649814200535 0.9537663287177605 1.0 13.537691148476965 -6.572304115968385 24.999196983562513 0.9880055556652882 1.0447392052404776 0.37224273147162024 0.0389637183573591 129.13762050368783 65316.49348416293 0.01268596892414475 0.01268597099252878 2.677292886159772e-07 6.572304115968385 0.05673364957518934 SST(ph)PPGESYFGVSSLQLK ddPTM_A459_Selumetinib_30min_R2 5 SSTPPGESYFGVSSLQLK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.087)S(0.087)T(0.827)PPGESYFGVSSLQLK;S(0.132)S(0.132)T(0.736)PPGESYFGVSSLQLK;S(0.13)S(0.13)T(0.741)PPGESYFGVSSLQLK;S(0.122)S(0.122)T(0.753)PPGES(0.002)YFGVSSLQLK;S(0.081)S(0.098)T(0.82)PPGES(0.001)Y(0.001)FGVSSLQLK 161.19 2.5613e-05 975613100.0 343060.0 320974.0 340158.0 395277.0 382279.0 300552.0 306192.0 320717.0 271046.0 332478.0 True False 323994.0985779899 345591.67370592285 318272.6046160268 341439.5907091425 334253.6944023791 341950.30986058875 320430.5347079376 321650.2333724425 325262.7736580048 322878.4962584125 1.003455176893182 1.070345897019206 0.9857349074163818 1.0574863134764938 1.03523058449474 1.0590680823380456 0.9924183196501396 0.9961958975273876 1.0073844416002362 1.0 18.300631834947687 -7.279091736409022 24.8956553095088 0.9986826530209533 1.035580027293799 0.3486606889903532 0.024248271780537494 871.3283819861958 1228857.380405844 0.00955919680714451 0.006457588397897597 5.259061670306977e-08 7.279091736409022 0.03689737427284567 SST(ph)PSDINSPR ddPTM_A459_Selumetinib_30min_R2 1 SSTPSDINSPR 11 0 Q674X7-3;A0A1B0GWK2;Q674X7-4;Q674X7-2;Q674X7;Q674X7-5 Q674X7-3 KAZN Kazrin 1 S(0.075)S(0.075)T(0.845)PS(0.004)DINSPR 151.13 0.0014064 5076600.0 43974.0 39583.0 47793.0 49367.0 53155.0 36569.0 39712.0 42807.0 40303.0 43313.0 True False 41530.1011218694 42618.88882059456 44718.05041308394 42643.12943717494 46477.19368827075 41606.04780966975 41558.68668783516 42931.561282919654 48364.72615990859 42062.441149311046 0.9873440529627852 1.0132290864742792 1.063134929671489 1.013805387229015 1.1049571165707774 0.9891496231038703 0.9880236513214322 1.020662617524348 1.1498316511927118 1.0 15.360244960760511 -4.998185592285466 4.468241017427282 1.0395426366942433 0.9910216453123915 0.10656973671206604 0.04980687940118045 0.4429822652517373 22.880906644273317 0.012632455224734785 0.04858297589341524 1.0041865674463288e-05 4.998185592285466 -0.04852099138185184 SST(ph)PSPSPLNLSSSR ddPTM_A459_Selumetinib_30min_R2 3 SSTPSPSPLNLSSSR 15 0 P37275-3;P37275-4;P37275-5;P37275;P37275-2 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 SS(0.002)T(0.998)PSPSPLNLSSSR;SST(1)PSPSPLNLSSSR;S(0.002)S(0.005)T(0.993)PS(0.001)PSPLNLSSSR 244.0 3.7385e-20 18123100.0 76790.0 74165.0 89417.0 83790.0 93550.0 65950.0 59337.0 73880.0 58464.0 75201.0 True False 72522.31921472574 79853.21702193854 83664.00756986851 72377.65745418797 81797.41265238886 75034.0138655069 62096.288074034885 74094.97856850759 70158.433620646 73029.7517343372 0.9930517014290645 1.0934340474334803 1.1456153907549338 0.991070840792101 1.1200560142932714 1.0274444604229338 0.8502875417121045 1.0145862036892224 0.9606828991540832 1.0 16.15619670566842 -7.009197741367837 24.763386650095185 0.9549277182427098 1.0703652459819555 0.4278854554989264 0.06123907847951036 358.4093787157572 964958.3492136035 0.021581036037966225 0.018032333611518424 9.790441091424111e-08 7.009197741367837 0.11543752773924565 SST(ph)VASLDTDSTK ddPTM_A459_Selumetinib_30min_R1 1 SSTVASLDTDSTK 13 0 C9IZZ8;C9J6Y2;C9J0J6;C9JZ07;G3V1A3;C9J5T5;C9JBU8;A8MPU2;O14713-2;O14713 C9IZZ8 ITGB1BP1 Integrin beta-1-binding protein 1 1 SS(0.002)T(0.995)VAS(0.003)LDTDSTK 223.36 1.3427e-08 14690000.0 4197.6 4890.6 5649.0 5455.9 5249.3 4346.7 4410.2 4351.0 3017.0 4462.0 True False 4295.395912892223 4318.0062784217425 4881.896827735868 4503.12948492715 4774.501741839188 4302.976144487826 4077.535063327608 4235.597345960168 5119.628647038345 5034.741163560552 0.8531512888846372 0.8576421583841786 0.9696420668194603 0.8944113190006677 0.9483112610425988 0.8546568740476771 0.8098797794888007 0.8412741009638652 1.0168603470804367 1.0 12.29770189573501 -8.27009261933295 24.869261552946778 1.0084302028307455 0.880714999946298 0.5577314634437454 0.04620753041516774 538.1639629694574 1546654.1287417307 0.04610642075016237 0.01266202626706044 5.369172790890548e-09 8.27009261933295 -0.1277152028844475 SST(ph)VPSSNT(ph)ASGGMT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SSTVPSSNTASGGMTR 16 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 3 S(0.131)S(0.157)T(0.633)VPS(0.065)S(0.021)NT(0.624)AS(0.456)GGMT(0.913)R 67.646 0.044355 0.0 8891.8 11263.0 11949.0 12355.0 12416.0 6347.3 9653.0 6812.8 5006.6 9117.8 True False 8397.629352695642 12126.83588374697 11180.214349087513 10672.227686436208 10856.191079551676 7221.582959947406 10101.883627056628 6832.624120080243 6008.059896092059 8854.54542311057 0.9483975688664528 1.369560525613844 1.2626525490407325 1.2052823918641205 1.2260585451644714 0.8155791872837318 1.140869818194221 0.7716515974097252 0.678528327429535 1.0 13.112202528097999 -6.9342802144412365 1.201737179706644 0.8374696995729057 1.225402418996363 0.4606117463615569 0.16311781983607085 0.39339353194092436 1.1771878647246614 0.08888731346482168 0.06809948789782352 1.1633751570773169e-07 6.9342802144412365 0.3879327194234573 SST(ph)VPSSNTASGGMTR ddPTM_A459_Selumetinib_30min_R1 2 SSTVPSSNTASGGMTR 16 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06;H0YKP9 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 S(0.071)S(0.014)T(0.915)VPSSNTASGGMTR;S(0.008)S(0.013)T(0.979)VPSSNTASGGMTR 179.55 2.476e-06 17811100.0 4997.9 6045.9 4839.9 5577.1 4847.1 4553.9 4030.5 4204.1 2362.8 3628.8999999999996 True False 5114.341345779499 5338.043217337341 4182.668163667695 4603.164180132923 4408.680660825009 4508.091900610371 3726.476140025832 4092.5936111586184 4009.499027915875 4094.7046634793564 1.2490134859772122 1.3036454777672521 1.021482257553978 1.1241748937813547 1.0766785453774 1.1009565453689525 0.9100720189327078 0.9994844433251642 0.9791912622359727 1.0 11.999543683805735 -4.324646098075013 0.40196120149851167 0.9712825848350033 1.6632659928595035 0.6934502259166853 0.06461700473868169 4.499540250713102 0.43329811999080514 0.05134710545177594 1.610429540297042 4.735369819976442e-05 4.324646098075013 0.6919834080245002 SSTELHPDLLTDCLTVQSLQPAT(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 SSTELHPDLLTDCLTVQSLQPATSPR 26 0 Q8NEA6-2;Q8NEA6 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 SSTELHPDLLTDCLTVQS(0.014)LQPAT(0.505)S(0.481)PR 135.19 6.193499999999999e-09 9121200.0 2154.1 2323.8 2603.1 2555.6 2754.2 2072.8 2740.3 1891.5 846.13 1466.6 True False 2204.286338851041 2051.72841569469 2249.6133178047853 2109.312434553386 2505.0830962935033 2051.949513951818 2533.596964771814 1841.331275542096 1435.820811109895 1654.8523958937487 1.3320138668080759 1.2398256308452194 1.35940421235564 1.2746227033826747 1.5137803845886593 1.239959236874178 1.5310108448696265 1.1126861103208145 0.867642827041647 1.0 10.69248682664399 -7.974830312262847 5.749593942351517 0.948745098985985 1.3495807328631464 0.7481958846750071 0.09979670761280902 0.07536078435014615 7.615715555688725 0.05542305654134502 0.02492777297346238 1.0596676781384027e-08 7.974830312262847 0.40083563387716137 SSTELHPDLLTDCLTVQSLQPATS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 SSTELHPDLLTDCLTVQSLQPATSPR 26 0 Q8NEA6-2;Q8NEA6 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 SSTELHPDLLTDCLTVQSLQPAT(0.108)S(0.891)PR;SSTELHPDLLTDCLTVQSLQPAT(0.096)S(0.904)PR 210.61 2.4757e-33 31759000.0 5238.0 7314.9 5900.8 7252.6 7788.3 6179.2 7161.0 5936.7 2176.48 4201.6 True False 5360.03520862623 6458.468107395247 5099.5037707742595 5986.069558163211 7083.849640136047 6117.042858264698 6620.840004645825 5779.239430880658 3693.3275961902596 4740.916287049757 1.1305905618430034 1.3622826720305397 1.0756367465723908 1.2626397927579323 1.4941942045014012 1.2902659502708276 1.3965317258883585 1.2190131782472462 0.7790324427956932 1.0 12.210950203496393 -8.154346325030055 5.180078634807388 0.8940929355416173 1.2900137169118313 0.610652078111952 0.12501852828126228 0.14122395520500106 5.453390968694335 0.08972512767910057 0.03224551013449429 7.008961508803101e-09 8.154346325030055 0.395920781370214 SSTELHPDLLTDCLTVQSLQPATS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SSTELHPDLLTDCLTVQSLQPATSPR 26 0 Q8NEA6-2;Q8NEA6 Q8NEA6-2 GLIS3 Zinc finger protein GLIS3 1 SSTELHPDLLTDCLTVQSLQPAT(0.098)S(0.902)PR;SSTELHPDLLTDCLTVQS(0.002)LQPAT(0.137)S(0.861)PR 203.51 1.4151e-32 18479700.0 44135.0 40874.0 60917.0 58021.0 67293.0 45557.0 47483.0 50293.0 48244.0 60841.0 True False 41682.15338640348 44008.904369375305 56997.66654141474 50118.43970819229 58839.051732947155 51832.06322472925 49691.053585779555 50439.34430354566 57894.148049987074 59084.362246097786 0.7054684488729734 0.7448485977739713 0.96468277518184 0.8482521906463051 0.9958481313189289 0.8772551865557707 0.8410187010025887 0.8536834855465824 0.9798556817596974 1.0 15.850488724922355 -5.171199286293506 5.330049760418569 0.9104219675802386 0.7170496658743662 0.6228168659130197 0.060457656900289695 0.14217801437508176 6.408118045030653 0.015145522438642905 0.04222831561427103 6.742185755658701e-06 5.171199286293506 -0.19337230170587238 SSTFPQTDVLSS(ph)SLEAEHR ddPTM_A459_Selumetinib_30min_R1 2 SSTFPQTDVLSSSLEAEHR 19 0 D4PHA4;Q86WP2-4;Q86WP2-3;Q86WP2;Q86WP2-2 D4PHA4 GPBP1 Vasculin 1 SSTFPQTDVLS(0.006)S(0.909)S(0.085)LEAEHR;SSTFPQTDVLS(0.001)S(0.701)S(0.298)LEAEHR 266.28 7.617399999999997e-49 169344000.0 13441.5 16637.9 16212.6 17484.3 16098.9 14179.4 15833.900000000001 14057.9 7698.4 10533.4 True False 13754.660797393943 14689.926933250128 14011.01796943716 14430.995225959374 14642.757337491646 14036.768109865108 14639.536175053972 13685.038825505284 13063.622531110363 11885.464494004644 1.1572674172163968 1.2359573275962528 1.1788363825835082 1.2141717501439482 1.2319886483929894 1.1810029062764558 1.2317176314344769 1.1514096762821844 1.0991259565581146 1.0 13.536910665673917 -8.43896270704052 1.4594702272368838 1.001723760536456 1.2055401851696048 0.85824847316053 0.02623332739442818 0.12503635445817843 0.5749222878160838 0.023058717962457866 0.006907801472149347 3.639462869304546e-09 8.43896270704052 0.20381642463314886 SSTFPQTDVLSSS(ph)LEAEHR ddPTM_A459_Selumetinib_30min_R1 1 SSTFPQTDVLSSSLEAEHR 19 0 D4PHA4;Q86WP2-4;Q86WP2-3;Q86WP2;Q86WP2-2 D4PHA4 GPBP1 Vasculin 1 SSTFPQTDVLSS(0.036)S(0.963)LEAEHR 206.45 2.5518999999999996e-16 13068000.0 913.92 1209.6 1300.6 1315.3 950.43 805.1 1071.0 790.05 532.48 808.2 True False 935.2125578212455 1067.979469672216 1123.985663684417 1085.6075462388749 864.4637743120455 797.0014249723124 990.2136077329537 769.0953075559254 903.5796691995283 911.9403425346563 1.0255194492458861 1.1711067268982343 1.2325210446994808 1.1904370226911183 0.9479389538896218 0.8739622405091966 1.0858315632585613 0.8433614258343852 0.9908319953124453 1.0 9.832795638786965 -6.265707902989177 24.647117340287114 0.9514466784449964 1.161598612128164 0.5934957594570083 0.08008500599637519 198.66965773853542 1147148.2525610502 0.024240372213509644 0.028464325020723442 5.423655510149094e-07 6.265707902989177 0.21015193368316765 SSTFPQTDVLSSS(ph)LEAEHR ddPTM_A459_Selumetinib_30min_R2 4 SSTFPQTDVLSSSLEAEHR 19 0 D4PHA4;Q86WP2-4;Q86WP2-3;Q86WP2;Q86WP2-2 D4PHA4 GPBP1 Vasculin 1 SSTFPQTDVLSS(0.088)S(0.911)LEAEHR;SSTFPQTDVLS(0.01)S(0.187)S(0.803)LEAEHR;SSTFPQTDVLS(0.001)S(0.221)S(0.777)LEAEHR;SSTFPQTDVLS(0.015)S(0.209)S(0.776)LEAEHR 210.31 9.998799999999999e-17 85827000.0 403251.0 389225.0 514596.0 520415.0 580597.0 421566.0 382556.0 433519.0 365301.0 478086.0 True False 380839.92376165366 419077.3059443679 481487.4536097608 449533.57923405076 507657.2142569645 479632.88990487164 400345.6120203331 434780.4685170665 438371.4073627473 464282.4149633948 0.8202764341003095 0.9026344579029748 1.0370572696528308 0.9682330511473133 1.0934233085200729 1.033062796364336 0.8622889842853457 0.9364568945635076 0.944191279347312 1.0 18.824643113244576 -4.981241230800432 3.707609432913868 0.9826774251625354 0.826524094741955 0.4257450103022383 0.060581101998757 0.23602482397755692 6.8988335538984815 0.017053725273499246 0.07717749585031908 1.0441400858649462e-05 4.981241230800432 -0.15615333042058044 SSTGPEPPAPT(ph)PLLAER ddPTM_A459_Selumetinib_30min_R1 2 SSTGPEPPAPTPLLAER 17 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 SSTGPEPPAPT(1)PLLAER;SSTGPEPPAPT(1)PLLAER 261.66 5.9558e-40 23406000.0 3807.8 3939.3999999999996 3770.8 4499.0 3607.3999999999996 3447.7 3894.6 2767.7 2306.1000000000004 2905.0 True False 3896.514331310985 3478.1732166226257 3258.746071521757 3713.3341066894995 3281.111306938197 3413.0192682611355 3600.8271864395524 2694.291605243384 3913.2832691200297 3277.8850470962343 1.1887281815336304 1.0611028656126364 0.9941611815852323 1.1328445181380031 1.0009842504528401 1.0412260403349447 1.0985214962402057 0.821960369729916 1.193843961241616 1.0 11.67854954578276 -4.779715699118063 3.669662021501893 1.0333944887092947 1.2059949534789318 0.19104418688234814 0.09401651677482904 0.42104811270893505 9.759388336151739 0.022068356613744556 0.20024358081208646 1.6606736734650306e-05 4.779715699118063 0.17260046476963709 SSTGS(ph)PTSPLNAEK ddPTM_A459_Selumetinib_30min_R2 1 SSTGSPTSPLNAEK 14 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746;Q15746-9;Q15746-11;Q15746-7;Q15746-10;Q15746-8 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 S(0.004)S(0.021)T(0.235)GS(0.475)PT(0.235)S(0.03)PLNAEK 91.789 0.016531999999999998 3292100.0 13750.0 13629.0 13758.0 17304.0 17925.0 16356.0 17728.0 16502.0 14590.0 16350.0 True False 12985.830045611141 14674.300475857899 12872.825258577792 14947.165348935021 15673.101248466804 18608.890535014863 18552.38712736558 16550.018087946828 17508.407678660795 15877.933017598301 0.8178539379916958 0.9241946328652252 0.81073684114363 0.9413797962473035 0.9870995948336303 1.171997042334774 1.1684384300401724 1.042328246983006 1.1026880929183513 1.0 13.95473549484194 -6.336206218621652 2.1191291875164717 1.1024463577188524 0.8624741013469532 0.7481451077286696 0.06116150234236547 0.153808248328276 1.356587944572824 0.020860248348622667 0.025549011310356064 4.610985764017643e-07 6.336206218621652 -0.23997225637189912 SSTGS(ph)YEER ddPTM_A459_Selumetinib_30min_R2 1 SSTGSYEER 9 0 Q7Z674;F8W6C0;G3V0F5;Q9UHY8;Q9UHY8-2;H7C434 Q7Z674 DKFZp779C2259;FEZ2 Fasciculation and elongation protein zeta-2 1 SST(0.034)GS(0.966)YEER 95.483 0.022335 23720000.0 43310.0 39259.0 49414.0 52075.0 45063.0 33448.0 40565.0 39508.0 36404.0 41518.0 True False 40903.00358366682 42270.03906241876 46234.75703789527 44982.2951656144 39401.78307166859 38055.15838928691 42451.35287802256 39622.96173909851 43685.81721274623 40319.26746328112 1.0144778453853933 1.048383111149383 1.1467161966670503 1.1156525898338783 0.9772445173402994 0.9438454809215931 1.052880063277021 0.9827301990340788 1.0834972945014698 1.0 15.2991818071598 -6.263327148695909 24.993903944341298 1.0050024198866978 1.0836277531014151 0.35206040096626257 0.04951272723785072 194.52353127482277 2575470.7930835243 0.01579630720646711 0.01882237516302412 5.453469032058557e-07 6.263327148695909 0.07862533321471732 SSTGSPTS(ph)PLNAEK ddPTM_A459_Selumetinib_30min_R2 1 SSTGSPTSPLNAEK 14 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746;Q15746-9;Q15746-11;Q15746-7;Q15746-10;Q15746-8 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 S(0.001)S(0.001)T(0.089)GS(0.005)PT(0.345)S(0.559)PLNAEK 163.34 0.00026881 6366400.0 36751.0 24580.0 30914.0 37869.0 29771.0 35535.0 46630.0 53082.0 38136.0 35762.0 True False 34708.52654590946 26465.206962842985 28925.026896618245 32711.17687233127 26030.90082388315 40429.6236953872 48798.38739559211 53236.459831801825 45764.26560886967 34729.458139165195 0.9993972957144376 0.762039155831158 0.8328672097535216 0.941885610229033 0.749533745086783 1.1641305641274546 1.4051007418558328 1.5328905973273987 1.3177362406717272 1.0 15.08387228102564 -6.94988570081901 3.9564246815216797 1.3529522277405988 0.8565373113061242 0.6866848287724905 0.1456263440267154 0.11331939807285304 3.7229959174883307 0.052364970802598616 0.044694521322469684 1.1223137900091882e-07 6.94988570081901 -0.49641491643447455 SSTLGQEERPPEPPPGPPSKS(ph)SPQAR ddPTM_A459_Selumetinib_30min_R2 1 SSTLGQEERPPEPPPGPPSKSSPQAR 26 2 G5E9Y3;Q8WWN8;Q8WWN8-2 G5E9Y3 ARAP3 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 1 SSTLGQEERPPEPPPGPPS(0.18)KS(0.574)S(0.245)PQAR 49.613 0.014352 4400000.0 23708.0 21165.0 16108.0 21311.0 22714.0 15584.0 19106.0 18634.0 16117.0 16064.0 True False 22390.40427064356 22788.287443798694 15071.628817064333 18408.40503647447 19860.46425426361 17730.5545425331 19994.466857820767 18688.221854975243 19340.85034660563 15600.19058071555 1.4352647908238925 1.4607698108489031 0.9661182495869884 1.180011548014698 1.2730911299772498 1.1365601241084218 1.2816809355224978 1.1979483044314225 1.2397829530694429 1.0 13.929276033519905 -5.230101002238391 24.99761001941026 1.1748168442311442 1.4480174460640263 0.5635094608457489 0.10087878560048384 493.99618474738196 394043.335527857 0.025055797232537744 0.06627714489786453 5.887067261188992e-06 5.230101002238391 0.2732006018328821 SSTLSSSSMSLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SSTLSSSSMSLSPK 14 0 O15119;O15119-2;O15119-3 O15119 TBX3 T-box transcription factor TBX3 1 SSTLSSSSMS(0.015)LS(0.985)PK;SSTLSSSSMSLS(1)PK 214.45 1.1835e-06 53360000.0 4249.4 4920.9 5108.0 5565.6 3852.8 4222.6 4543.1 4225.1 3030.4 4667.700000000001 True False 4348.402752106967 4344.758740335654 4414.361656235582 4593.672439251184 3504.314920267088 4180.124477814042 4200.410309329209 4113.036622941007 5142.367468341067 5266.844762248227 0.8256181733844742 0.8249262958115045 0.8381415924534007 0.8721867923994612 0.6653537513361646 0.7936676827417439 0.7975192926582868 0.7809299131849292 0.9763658699798046 1.0 12.362723222028425 -8.286218119320775 6.830802755554681 0.9908272477745573 0.7994926386610046 0.6798381404313515 0.05171903353150243 0.12208422017270908 22.761266715196253 0.0483678177773893 0.0135452622797921 5.17346935247528e-09 8.286218119320775 -0.1913346091135527 SSTLSSSSMSLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 SSTLSSSSMSLSPK 14 0 O15119;O15119-2;O15119-3 O15119 TBX3 T-box transcription factor TBX3 1 SSTLSSSSMSLS(1)PK;SSTLSSSS(0.001)MS(0.03)LS(0.969)PK;SSTLSSSS(0.001)MS(0.008)LS(0.99)PK;SSTLSS(0.004)S(0.117)S(0.084)MS(0.045)LS(0.749)PK 139.21 0.0021718 50124600.0 214630.0 193640.0 193626.0 178042.0 155667.0 119976.0 160118.0 158698.0 100218.0 142394.0 True False 202701.72383196524 208491.56534926457 181168.31396404898 153792.37246041934 136110.71977936296 136501.60496630846 167563.8042677979 159159.78490613168 120264.40032488179 138282.7152359566 1.4658500412440432 1.5077196379425164 1.310129857190866 1.1121590445920742 0.9842930806436113 0.9871197910266011 1.2117480046720082 1.1509738193566117 0.8696994423321127 1.0 17.07726131131718 -5.621197660644289 2.2145986083910496 1.0475000305907403 1.4885860965615945 0.8016779128849778 0.09046689788870936 0.136884677924012 1.3493447164278778 0.02776685319378603 0.06066910412206835 2.3922267333635487e-06 5.621197660644289 0.4410860659708542 SSTPGS(ph)PTHVSSGSNASR ddPTM_A459_Selumetinib_30min_R1 1 SSTPGSPTHVSSGSNASR 18 0 Q14CZ0 Q14CZ0 C16orf72 UPF0472 protein C16orf72 1 SSTPGS(0.936)PT(0.064)HVSSGSNASR 140.68 0.00031612 1638700.0 72.33 226.83 205.7 144.08 121.86 184.64 182.85 132.24 68.241 162.28 True False 74.01514827031978 200.27263814959394 177.76706982922065 118.91913271656442 110.83778451613041 182.7826892397065 169.05747728662047 128.73256562394226 115.79999287455873 183.11021874105924 0.4042109106700728 1.0937272617909135 0.9708200397084639 0.6494401761636851 0.6053063847456209 0.9982112986178238 0.9232552855266307 0.7030332141429322 0.6324059556627716 1.0 7.516568494922417 -11.98256652759973 2.1697213528538195 3.080724201858555 0.7907360481722989 0.09310557782408935 0.20526856663521592 9072479.240630353 729575.7854679399 92973172.75399679 0.051324966774284136 1.0409586356824264e-12 11.98256652759973 -2.289988153686256 SSTPGS(ph)PTHVSSGSNASR ddPTM_A459_Selumetinib_30min_R2 1 SSTPGSPTHVSSGSNASR 18 0 Q14CZ0 Q14CZ0 C16orf72 UPF0472 protein C16orf72 1 SSTPGS(0.769)PT(0.231)HVS(0.001)SGSNASR 189.44 6.3837e-15 0.0 924.7 900.84 2655.0 4529.9 4433.1 2290.0 982.92 1069.1 3131.1 2296.7 True False 873.30887586739 969.9315313428599 2484.180190545432 3912.9198054866347 3876.1743455831647 2605.426713449746 1028.6277276190306 1072.2109040009666 3757.4074902436505 2230.38830345676 0.39155015048899566 0.4348711521844043 1.1137882075041974 1.7543670756442764 1.7378921596637182 1.1681493798240128 0.46118773400345375 0.4807283567346565 1.6846427523047198 1.0 11.123079185257794 -5.2681019713043415 5.385946674258735 1.174054703890506 0.40378623802256985 0.32504699685409966 0.43996524849311863 0.20836398391143302 21.877149510184804 0.1289162161087939 0.3081202707078593 5.393839615833562e-06 5.2681019713043415 -0.7702684658679362 SSTPGSPT(ph)HVSSGSNASR ddPTM_A459_Selumetinib_30min_R1 1 SSTPGSPTHVSSGSNASR 18 0 Q14CZ0 Q14CZ0 C16orf72 UPF0472 protein C16orf72 1 SST(0.008)PGS(0.379)PT(0.556)HVS(0.046)S(0.002)GS(0.003)NAS(0.005)R 83.792 0.019798 1100300.0 118.74 240.6 168.93 177.66 415.88 171.64 211.39 179.29 0.0 126.45 True False 121.50641097217986 212.43044014809456 145.9902338660683 146.63501609123284 378.2637274295774 169.91345743665093 195.44468210893461 174.53464678400337 0.0 142.68108922730428 0.8515943607537844 1.4888479005768807 1.0231925944544218 1.0277116391901773 2.6511132587933077 1.1908617908429542 1.3698008836866462 1.223250030744813 0.0 1.0 7.156650324266745 -8.102724489950866 6.268408395228992 0.5091917866955075 1.3856998114294727 0.30447582409797025 0.5193455183270675 0.28491620597744977 14.560083902393165 0.3572122612830297 0.1325142231859136 7.893607176761333e-09 8.102724489950866 0.8765080247339653 SSTPLHS(ph)PSPIR ddPTM_A459_Selumetinib_30min_R1 3 SSTPLHSPSPIR 12 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 SSTPLHS(0.997)PS(0.003)PIR;SST(0.001)PLHS(0.995)PS(0.004)PIR;SSTPLHS(0.998)PS(0.002)PIR 100.68 0.0087178 44680000.0 4913.200000000001 5546.4 6651.4 7017.6 7985.5 6383.2 6813.6 5841.4 2792.6000000000004 3604.3999999999996 True False 5027.668000577013 4897.024909548592 5748.176413524935 5792.107896666868 7263.212934954536 6318.9908034818845 6299.644666339168 5686.467096458685 4738.838236565887 4067.0598498291442 1.2361922829309295 1.2040700383974714 1.4133493545137807 1.424151133873821 1.7858633025180735 1.5536999790517818 1.5489431921204242 1.3981763992722092 1.165175436689225 1.0 11.989770505955466 -8.37900285059598 2.419038084662393 1.0063623633832612 1.4580104160839598 0.4813012794499073 0.15589066658969084 0.2662566146257224 3.0539958536644276 0.16816009644802715 0.046645686547121326 4.1782762412581185e-09 8.37900285059598 0.4516480527006985 SSTPLHS(ph)PSPIR ddPTM_A459_Selumetinib_30min_R2 2 SSTPLHSPSPIR 12 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 1 S(0.002)S(0.01)T(0.029)PLHS(0.939)PS(0.019)PIR;SS(0.001)T(0.036)PLHS(0.889)PS(0.074)PIR 86.777 0.019464 42981800.0 53341.0 56578.0 69959.0 75627.0 70862.0 46018.0 49294.0 49378.0 42884.0 57388.0 True False 50376.520760941385 60917.350673056564 65457.914105599986 65326.472136148266 61959.6820456823 52356.56179018792 51586.26867420797 49521.68180503205 51461.99827907403 55731.05932806925 0.9039218232761813 1.093059263676605 1.174532027469138 1.172173522695741 1.1117621447126516 0.9394503248535644 0.9256287121789244 0.8885831778921559 0.9233988892286302 1.0 15.766193955768758 -6.7799472754235435 7.264164604071072 0.9272142237581688 1.1005018348096451 0.5149148177093643 0.07508108114298931 0.1294616963713849 30.11541854963329 0.02754834973938089 0.025042257157740288 1.659788398204964e-07 6.7799472754235435 0.1732876110514764 SSTPLPTISS(ph)SAENTR ddPTM_A459_Selumetinib_30min_R1 2 SSTPLPTISSSAENTR 16 0 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 SSTPLPTIS(0.002)S(0.499)S(0.499)AENTR;SSTPLPTIS(0.003)S(0.862)S(0.135)AENTR 276.14 1.495e-51 25723000.0 3291.7 5071.1 3809.2 3959.7 3733.3999999999996 4330.2 4559.4 4418.7 1894.1599999999999 3758.8999999999996 True False 3368.390205466772 4477.373254509573 3291.931562437857 3268.2127277747077 3395.7146291853032 4286.642119507023 4215.480787206003 4301.501722039578 3214.25117602723 4241.391429786585 0.7941710311882862 1.0556378322136757 0.7761442481632727 0.7705520185716872 0.8006133565833526 1.010668831318574 0.9938910041646672 1.0141723048315816 0.7578294126437093 1.0 12.050321917267029 -6.758831625950772 24.999849643760413 0.9586092500271242 0.844093861255841 0.2358950510305452 0.10403233328345762 111.27405769495444 1066757.1516930298 0.03591120654397315 0.034363187362165246 1.7424822951308753e-07 6.758831625950772 -0.1145153887712832 SSTPLPTISS(ph)SAENTR ddPTM_A459_Selumetinib_30min_R2 1 SSTPLPTISSSAENTR 16 0 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 SSTPLPT(0.004)IS(0.282)S(0.432)S(0.282)AENTR 158.91 6.5413e-05 1857600.0 8667.5 6008.2 9758.0 9596.1 7451.7 6053.2 11357.0 10814.0 6326.7 8594.4 True False 8185.795048751599 6469.009620592075 9130.180903707085 8289.094625804177 6515.5508269567745 6886.973354521396 11885.123003468576 10845.466949645923 7592.216782767873 8346.257341067094 0.9807743416290374 0.775079099078557 1.0939251607762868 0.9931510960030369 0.7806553956702875 0.8251570821611972 1.4240062962100122 1.2994407560717864 0.9096552469585351 1.0 13.026913688723452 -7.2387778260096605 24.984053451419644 1.1832290138058186 0.9085925954130852 0.3554959664519831 0.1636331800924942 823.162344307945 907526.4324563621 0.06339639890099454 0.049071351398282996 5.7706159790308946e-08 7.2387778260096605 -0.27463641839273334 SSTPLPTISSS(ph)AENTR ddPTM_A459_Selumetinib_30min_R2 2 SSTPLPTISSSAENTR 16 0 P42166;G5E972;P42167;H0YJH7;P42167-2;P42167-3 P42166;G5E972 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 SSTPLPTISS(0.048)S(0.952)AENTR;SSTPLPTISS(0.039)S(0.961)AENTR 287.03 1.8970999999999996e-74 15973200.0 76648.0 46408.0 73136.0 76410.0 56826.0 40914.0 86783.0 69320.0 54372.0 59583.0 True False 72388.21100625469 49967.344374760694 68430.5093844561 66002.82618539777 49687.00984911437 46549.532119686846 90818.58145725215 69521.70972345622 65247.91928061311 57862.68397477431 1.2510344497295165 0.8635504083520279 1.18263628099742 1.1406803426915388 0.8587055842548855 0.8044827671661494 1.5695535571223282 1.2014947276514991 1.127633818525571 1.0 15.820345624132031 -7.241524914221282 24.97931417801993 1.2414618336045533 1.0158564811377202 0.21615412364606057 0.1928159358232795 1198.1409065376183 1502866.2448609131 0.0737228827308878 0.05702749371620659 5.734229699811916e-08 7.241524914221282 -0.2256053524668331 SSTPRES(ph)PCGK ddPTM_A459_Selumetinib_30min_R1 1 SSTPRESPCGK 11 1 P49792;H7BZ48;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD6;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 SSTPRES(1)PCGK 133.98 0.0081538 3777600.0 1736.1 1317.0 1904.2 1677.3 1456.3 1429.4 1223.9 1467.3 855.23 1266.7 True False 1776.5477521374562 1162.8050277433106 1645.6200990218872 1384.3910418204707 1324.5779221306477 1415.0215337913592 1131.5802376324575 1428.3824375378902 1451.2628464721925 1429.293283702857 1.2429553629014265 0.8135524325216461 1.1513522926229627 0.9685843049887854 0.926736266960603 0.9900148205590639 0.7917061183558374 0.9993627296963103 1.0153709270307485 1.0 10.481086265147454 -4.740810808743513 24.890866786847933 0.962431143029228 1.2429564347902808 0.42899548677690746 0.09729026748771567 1422.9692846486075 1716891.2268134446 0.023545263553195275 0.9998839780243405 1.816306726278301e-05 4.740810808743513 0.2805252917610528 SSTPRES(ph)PCGK ddPTM_A459_Selumetinib_30min_R2 1 SSTPRESPCGK 11 1 P49792;H7BZ48;Q99666;O14715;J3KQ37 P49792;Q99666 RANBP2;RGPD6;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 SSTPRES(0.999)PCGK 64.22399999999999 0.046173 6790400.0 50186.0 52293.0 42407.0 58040.0 59468.0 40964.0 43535.0 46122.0 34040.0 61507.0 True False 47396.863030475695 56303.70495150321 39678.57978925053 50134.851875415414 51997.0981893347 46606.41916583201 45559.463762965934 46256.20738409187 40848.951157067415 59731.133095621975 0.7935034976584041 0.9426190670344076 0.6642864069852844 0.8393420529149492 0.8705191998633934 0.7802701330179195 0.7627423322110934 0.7744069965999396 0.6838803993835747 1.0 15.866195469417576 SSTQFGS(ph)YK ddPTM_A459_Selumetinib_30min_R1 1 SSTQFGSYK 9 0 Q4ADV7-2;Q4ADV7-3;Q4ADV7 Q4ADV7-2 RIC1 RAB6A-GEF complex partner protein 1 1 SSTQFGS(0.657)Y(0.343)K 93.195 0.024889 457350000.0 1760.7 1546.5 1536.2 1410.6 890.65 2051.7 1806.1 1357.2 1005.9 1184.3 True False 1801.7208842741875 1365.435061051656 1327.5924777425814 1164.2651902414332 810.0908647570288 2031.06176079455 1669.8644229005479 1321.2026471930917 1706.9388319707884 1336.3164410588884 1.348274127980133 1.0217902130798409 0.9934716336278897 0.871249619078904 0.6062118521232278 1.5198958108942744 1.2496025429256548 0.9886899589038801 1.2773462778159201 1.0 10.38404596454665 -6.768748064285429 24.999999047321914 1.2090559174751498 0.9671946503496108 0.2278053713182363 0.2199094587312788 276.44695973077637 945605.6467987243 0.07943164501267631 0.07145573726834743 1.7031462228289154e-07 6.768748064285429 -0.24186126712553901 SSTQTLEDS(ph)WR ddPTM_A459_Selumetinib_30min_R1 2 SSTQTLEDSWR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 SSTQTLEDS(1)WR;SSTQT(0.001)LEDS(0.999)WR 118.76 0.0052151 7049000.0 2279.7 2953.1 2379.8 2447.3 2588.5 2499.7 2826.3 2733.8 1548.06 2349.2 True False 2332.8125744759864 2607.3496791410553 2056.636231305686 2019.9249965106046 2354.370632036792 2474.555287546004 2613.1099155328147 2661.290743366104 2626.9447541710906 2650.7427031457732 0.8800599815695115 0.9836298619427599 0.7758716939463682 0.7620222793081559 0.8881928182779636 0.933532811241665 0.98580292701804 1.0039792772824812 0.9910221580742482 1.0 11.372180925100933 -6.929809325454668 2.155250151872788 0.9958187487393309 0.8531709765133415 0.565304610426181 0.057247973738221415 0.26445293239893236 2.494202850765962 0.026670928073408855 0.02193976977941103 1.1754135003444676e-07 6.929809325454668 -0.14264777222598934 SSTQTLEDS(ph)WR ddPTM_A459_Selumetinib_30min_R2 2 SSTQTLEDSWR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 SSTQTLEDS(1)WR;SSTQTLEDS(1)WR 129.76 0.0025233 10664200.0 37775.0 34593.0 39009.0 48333.0 46240.0 44780.0 52508.0 54268.0 46258.0 31987.0 True False 35675.61672530623 37246.17186597347 36499.20340978783 41749.96202092444 40430.917809155115 50948.03852763299 54949.7260426281 54425.910895448964 55510.892556510735 31063.452197793107 1.1484755943462328 1.1990351757690219 1.1749886386542994 1.3440219636596138 1.3015590653516456 1.6401280257978725 1.768951039077749 1.7520882916972003 1.787016208084383 1.0 14.922930550288088 -6.680081955507085 2.8735607285257543 1.65244636303028 1.2183984269446628 0.38035418679770505 0.22171097676795906 0.23545892112764777 3.9389868213057526 0.07592491903863752 0.0739057977666569 2.0889018979643674e-07 6.680081955507085 -0.4340479360856171 SSTRPPS(ph)IADPDPSDLPVDR ddPTM_A459_Selumetinib_30min_R1 1 SSTRPPSIADPDPSDLPVDR 20 1 Q9NX94;Q9NX94-2 Q9NX94 WBP1L WW domain binding protein 1-like 1 S(0.024)S(0.024)T(0.088)RPPS(0.863)IADPDPSDLPVDR 65.085 0.0095011 2721300.0 2908.5 3750.6 4662.3 3728.9 3556.4 3350.7 3753.5 3396.3 1882.3 2822.9 True False 2976.262391044174 3311.4780083933647 4029.1852681807304 3077.7176151221333 3234.724247933419 3316.9950001921834 3470.370473039812 3306.219091262818 3194.125622247356 3185.2467123745128 0.9343899106720852 1.0396299902071793 1.264952335568721 0.9662415169177839 1.015533344832188 1.04136203557038 1.089513870168238 1.0379789667212698 1.0027875108820767 1.0 11.637189405003827 SSTTVSSFANSKPGS(ph)AK ddPTM_A459_Selumetinib_30min_R2 2 SSTTVSSFANSKPGSAK 17 1 A0A669KAX4;Q13620-1;A0A669KAU9;K4DI93;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 SSTTVS(0.002)SFANS(0.013)KPGS(0.985)AK;SST(0.001)T(0.004)VS(0.005)S(0.005)FANS(0.055)KPGS(0.929)AK 55.744 0.042547 21689000.0 99086.0 92047.0 102795.0 108502.0 102433.0 86137.0 90189.0 90903.0 60312.0 93168.0 True False 93579.19679268547 99106.70892224586 96181.28161473374 93723.84042361005 89564.45077736121 98001.58987616615 94382.9672061131 91167.51268019812 72376.08525808009 90477.9977604648 1.0342757256900281 1.09536806047173 1.0630350360909626 1.0358743865192335 0.989903103453702 1.0831538307867912 1.0431593264915795 1.0076208021485928 0.7999302266799884 1.0 16.465279383003953 -8.058353201101296 6.867524285496897 0.899397234386158 1.0484838011054318 0.5582080356632124 0.052410467088018095 0.17037605928985206 16.59855492026778 0.03340034013650957 0.01261826797707464 8.742724615670335e-09 8.058353201101296 0.14908656671927378 SSTVAS(ph)LDTDSTK ddPTM_A459_Selumetinib_30min_R1 1 SSTVASLDTDSTK 13 0 C9IZZ8;C9J6Y2;C9J0J6;C9JZ07;G3V1A3;C9J5T5;C9JBU8;A8MPU2;O14713-2;O14713 C9IZZ8 ITGB1BP1 Integrin beta-1-binding protein 1 1 SST(0.001)VAS(0.994)LDT(0.004)DSTK 255.15 1.3804e-23 15561000.0 2996.5 3551.1 3671.3 4179.1 3508.8 3413.8 3384.8 3475.0 1980.2 3142.5 True False 3066.31261982598 3135.3355611383995 3172.7576250073794 3449.298636422782 3191.429659528955 3379.4602714824 3129.481810881887 3382.831711609191 3360.2547719142613 3545.8704855421397 0.8647559555061306 0.8842216809447364 0.8947753839131792 0.9727649812611268 0.9000412374173353 0.953069291521431 0.8825708168535689 0.9540200989862095 0.9476529911668505 1.0 11.791924126798738 -1.5228787453692167 0.060371272417767886 1.1036583409727896 0.5487542384757765 0.5484818883458058 0.029039729472537273 273.937568731442 1.2398201677211453 2.2997747291788833 13.357149139698054 0.029999999993860445 1.5228787453692167 -0.554904102497013 SSTVAS(ph)LDTDSTK ddPTM_A459_Selumetinib_30min_R2 2 SSTVASLDTDSTK 13 0 C9IZZ8;C9J6Y2;C9J0J6;C9JZ07;G3V1A3;C9J5T5;C9JBU8;A8MPU2;O14713-2;O14713 C9IZZ8 ITGB1BP1 Integrin beta-1-binding protein 1 1 SSTVAS(0.964)LDT(0.036)DSTK;SST(0.002)VAS(0.991)LDT(0.007)DSTK 189.86 0.00015935 18506300.0 55120.0 44482.0 48818.0 51375.0 49736.0 46522.0 47908.0 45130.0 33781.0 52213.0 True False 52056.6510628426 47893.62636782676 45677.10302901957 44377.636373181755 43487.71903451854 52929.98321533144 50135.81692790104 45261.32082832628 40538.14392000276 50705.47502433397 1.0266475373292565 0.9445454626910055 0.9008317742235676 0.875204035696038 0.857653320743932 1.0438711636155644 0.9887653533240829 0.8926318273639089 0.7994825785686491 1.0 15.62985391305018 -7.9290150456088275 9.770387792982977 0.8819245212515663 0.9435348094420392 0.08016194342257044 0.07323211413612976 0.779662083107999 100.61299632160252 0.04136270456318634 0.019835065616301887 1.1775651774880082e-08 7.9290150456088275 0.06161028819047287 SSVLPS(ph)PSAGR ddPTM_A459_Selumetinib_30min_R2 1 SSVLPSPSAGR 11 0 P35658-4;P35658-3 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 SSVLPS(0.766)PS(0.234)AGR 84.18799999999997 0.036665 6743400.0 40787.0 33216.0 41769.0 45438.0 38920.0 33321.0 31977.0 35006.0 25419.0 39157.0 True False 38520.22182329759 35763.56039372634 39081.628014648624 39249.266015077985 34030.52165078539 37910.66529207815 33463.99386122343 35107.86166444472 30503.51026620145 38026.435667895836 1.0129853389287977 0.9404920489016553 1.027748915411592 1.0321573748815627 0.8949174713084131 0.9969555291264012 0.8800192096225236 0.9232488148786674 0.8021659072284368 1.0 15.214715096713004 -6.878986706796747 1.165196622975439 0.8950758028258765 0.9957309949463782 0.294602613872713 0.06059228674594277 0.5630464808345157 1.5998301721802435 0.03197054060842902 0.02576319850582656 1.3213360779890346e-07 6.878986706796747 0.10065519212050167 SSVPTT(ph)SIPGTPTVDLGT(ph)S(ph)GT(ph)PVS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 SSVPTTSIPGTPTVDLGTSGTPVSK 25 0 Q8WXI7;M0R2Y5;M0QZZ9;M0R2S7 Q8WXI7 MUC16 Mucin-16 5 S(0.134)S(0.134)VPT(0.135)T(0.511)S(0.174)IPGT(0.091)PT(0.096)VDLGT(0.934)S(0.931)GT(0.931)PVS(0.93)K 43.611 0.027318 6423300.0 9799.4 10624.0 9101.2 11978.0 11258.0 7458.8 5441.6 8657.4 6207.5 7200.9 True False 9254.788578106307 11438.826638455823 8515.63870063732 10346.575736797486 9843.66939220303 8486.181995754998 5694.645182325842 8682.591600690275 7449.173452041602 6992.991306814901 1.3234377353060929 1.6357558785048552 1.2177390657326501 1.4795636492089452 1.407647880615846 1.2135267474857194 0.8143360877306143 1.241613383993314 1.0652341930958982 1.0 12.771693996396165 -6.926766106521173 3.824087252863111 1.0455711064783664 1.4171931569480505 0.6206678929671635 0.1403943839834119 0.15063789227671767 4.372572677914583 0.050431051433084954 0.043468497109080954 1.1836788657561205e-07 6.926766106521173 0.3716220504696841 SSVS(ph)SVGAR ddPTM_A459_Selumetinib_30min_R2 1 SSVSSVGAR 9 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67;Q8N4M4;E9PRA3;E9PRP1;E9PS62;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 S(0.019)S(0.073)VS(0.454)S(0.454)VGAR 89.88600000000002 0.034702 0.0 23853.0 20414.0 26355.0 25734.0 26409.0 19030.0 20246.0 23259.0 16684.0 20429.0 True False 22527.345751124543 21979.688158644305 24659.34799315438 22228.984806373894 23091.26532054448 21651.209762859657 21187.479116687922 23326.679839265264 20021.266189909296 19839.161689083532 1.1354988736000968 1.1078939978970277 1.2429632047771024 1.1204598840789406 1.16392344003378 1.091336927546349 1.0679624194174646 1.1757895925663397 1.0091790421228315 1.0 14.276063444964059 -8.281148445539223 0.5180745038021574 0.994147061438133 1.1564393211236133 0.48318159094665647 0.0508528063473076 0.7962688449684774 0.5389086537622599 0.05458400787096634 0.028668507390263335 5.234214960968206e-09 8.281148445539223 0.16229225968548022 SSVSS(ph)VGAR ddPTM_A459_Selumetinib_30min_R2 1 SSVSSVGAR 9 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67;Q8N4M4;E9PRA3;E9PRP1;E9PS62;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 SS(0.001)VS(0.143)S(0.856)VGAR 104.42 0.01436 5732900.0 28558.0 25191.0 29628.0 33200.0 29786.0 20459.0 23574.0 27269.0 17420.0 20455.0 True False 26970.860686731852 27123.06869816835 27721.766736527326 28678.102726805515 26044.016389781442 23277.041541689217 24670.237710994807 27348.34827537403 20904.486755467515 19864.411001527427 1.3577478176754394 1.3654101647455232 1.395549394059342 1.443692577877108 1.3110892836328674 1.1717962108163884 1.2419314979486604 1.376751028423201 1.0523587512290253 1.0 14.277898396344542 -8.271146433000908 0.3579777926003 0.9690818406441893 1.4103136310809365 0.6807676928861949 0.08119037431940918 0.8468805863698292 0.3327672395670328 0.13876330249657548 0.09330240845109998 5.356160310257339e-09 8.271146433000908 0.4412317904367472 SSWLS(ph)TEGGR ddPTM_A459_Selumetinib_30min_R2 1 SSWLSTEGGR 10 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 SS(0.001)WLS(0.989)T(0.01)EGGR 87.184 0.034010000000000006 3479000.0 4714.3 6325.8 7244.8 6556.8 7286.9 5119.9 6447.0 7061.7 5060.6 5961.9 True False 4452.298078838149 6810.968519347117 6778.677455541827 5663.75252888911 6371.454476287462 5825.119751175259 6746.798274488148 7082.248377872629 6072.861404978128 5789.7644561235065 0.7689946823534773 1.1763809341403415 1.1708036668697988 0.9782353965883499 1.1004686847923035 1.006106516995585 1.1652975394106821 1.2232360109886915 1.0488961081232253 1.0 12.499288941184922 -7.262864015299335 24.95731794058116 1.1279604143634245 1.0467662881448214 0.06973941038274911 0.12315538007782693 327.08441283579015 5729918.1864013 0.04863585951975274 0.03478795928396855 5.4592877355413385e-08 7.262864015299335 -0.08119412621860311 SSWSS(ph)SDEKR ddPTM_A459_Selumetinib_30min_R1 1 SSWSSSDEKR 10 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 SSWS(0.053)S(0.473)S(0.473)DEKR 139.32 0.0058631 0.0 2509.8 2601.8 2853.5 3895.2 2993.1 2601.3 2681.0 2586.7 1591.8 2798.3 True False 2568.273456779325 2297.180046455996 2466.0103731535314 3214.976441959754 2722.3746334747243 2575.1332837914256 2478.770011514516 2518.092313214244 2701.1683395278883 3157.489062750222 0.8133910856819625 0.7275338095566091 0.7810036152605382 1.0182066756422776 0.8621960612916562 0.8155636433300721 0.7850446865381916 0.7974983485836517 0.855479872090239 1.0 11.62456202132152 -12.79017850761032 0.9469777769235403 3.726089089808623 0.8280456277167482 0.3310504422748656 0.0731720220844218 31231.23971589621 557.1646984727898 181223.2632212093 0.024839828732924545 1.621143623416659e-13 12.79017850761032 -2.898043462091875 SSWSSS(ph)DEKR ddPTM_A459_Selumetinib_30min_R1 1 SSWSSSDEKR 10 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 SSWS(0.009)S(0.238)S(0.753)DEKR 146.71 0.004151600000000001 0.0 2511.1 2893.7 3579.1 3732.8 2974.8 2993.9 2818.4 2812.3 1686.0 2261.7 True False 2569.6037442499655 2554.9042587553677 3093.0778785890334 3080.9365533342 2705.7298652435966 2963.7840842437045 2605.8058188931427 2737.708668362168 2861.018859432101 2552.011225823599 1.0068935897492728 1.0011336286073096 1.2120157808439178 1.2072582291795773 1.0602343116145143 1.1613522911864214 1.021079293274732 1.0727651354584615 1.1210839632998784 1.0 11.317418959926474 -7.270118133180345 24.862349096313007 1.0597958641564023 1.1103320662311826 0.1093189573730643 0.07514644289760372 1708.9331952504024 4895628.27688133 0.03330820997596814 0.022932783190677302 5.368857373041289e-08 7.270118133180345 0.05053620207478038 SSYLES(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 SSYLESPR 8 0 H0YIQ2;P49750-3;P49750-1;P49750;F8VU51 H0YIQ2 YLPM1 YLP motif-containing protein 1 1 SSYLES(1)PR;SSYLES(0.999)PR;SSYLES(1)PR 102.06 0.016528 26565800.0 11132.7 14098.7 10346.099999999999 10368.4 11523.900000000001 10034.4 13115.7 10953.099999999999 6080.0 11254.0 True False 11392.070249536702 12448.017649692183 8941.156447059306 8557.753578972977 10481.565279709792 9933.463046506235 12126.37218948935 10662.588207317021 10317.315934369608 12698.560523243035 0.8971150886500108 0.9802699783891043 0.7041078735415484 0.6739152491582917 0.8254136569672345 0.7822511085665453 0.9549406932615417 0.8396690465663855 0.8124791715946957 1.0 13.632377345548425 -7.241634962680892 24.56181257820002 0.8884113253969494 0.8078602535169273 0.17230895282811942 0.09611503866610183 1455.5314144891809 1805179.710521779 0.03971082172809795 0.0307101494526313 5.7327768533524925e-08 7.241634962680892 -0.0805510718800222 SSYLES(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SSYLESPR 8 0 H0YIQ2;P49750-3;P49750-1;P49750;F8VU51 H0YIQ2 YLPM1 YLP motif-containing protein 1 1 SSYLES(1)PR;SSYLES(1)PR;SSYLES(1)PR;SSYLES(1)PR 95.775 0.021615 43285200.0 170535.0 147051.0 162249.0 194764.0 202861.0 143814.0 169849.0 175182.0 173359.0 178767.0 True False 161057.34740569425 158329.3388565103 151810.07598335415 168236.80721336 177375.78757965 163623.0730864899 177747.3150494086 175691.75061705874 208035.64405517204 173605.5322175533 0.9277201328115839 0.912006298613228 0.8744541377466807 0.9690751502235223 1.0217173687608758 0.9424991876494241 1.0238574357565116 1.0120170041406924 1.1983238172068893 1.0 17.40545339673337 -6.957332219552285 0.6954623509105206 1.0805733931756576 0.9083386642193745 0.5130497907093636 0.05925668163419855 0.5866328181511304 0.6015260239611064 0.04661573829776034 0.03945204515059791 1.1032343626922451e-07 6.957332219552285 -0.1722347289562831 ST(ph)ELLIR ddPTM_A459_Selumetinib_30min_R1 2 STELLIR 7 0 K7EK07;Q5TEC6;Q6NXT2;Q71DI3;Q16695;P84243;P68431;K7EMV3;K7EP01;A0A590UJJ6;B4DEB1;K7ES00 K7EK07 H3F3B;HIST2H3PS2;H3F3C;HIST2H3A;HIST3H3;H3F3A;HIST1H3A Histone H3;Histone H3.3C;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1 1 S(0.02)T(0.98)ELLIR;S(0.016)T(0.984)ELLIR 131.22 0.0093901 3831700.0 5269.0 5538.299999999999 7149.0 6890.9 6095.9 5819.0 5986.2 7157.7 2711.5 4006.9 True False 5391.75744831073 4889.873261314179 6178.205066646079 5687.5336732133055 5544.526921318554 5760.466143229267 5534.65611448273 6967.854544513703 4601.217459875526 4521.224645511156 1.1925435852128852 1.0815373366083527 1.3664892924044454 1.257963078401801 1.2263329863123194 1.2740942100606474 1.2241497710090001 1.541143183723829 1.0176927316460131 1.0 12.142497887104014 -8.477023990821875 24.981346428268758 0.9999991607968698 1.265067651688905 0.4595586022461291 0.11346971681743755 312.48238603946487 170238.45718440748 0.10826062225443149 0.027952772469422543 3.3340799449389547e-09 8.477023990821875 0.2650684908920352 ST(ph)ELVLSPDMPR ddPTM_A459_Selumetinib_30min_R2 2 STELVLSPDMPR 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 S(0.368)T(0.632)ELVLSPDMPR;S(0.373)T(0.627)ELVLSPDMPR 151.13 0.005407899999999999 7777300.0 43199.0 48609.0 53745.0 52610.0 54626.0 40495.0 39655.0 40031.0 33584.0 41199.0 True False 40798.17251929856 52337.153997430236 50287.10521313156 45444.42724268791 47763.39351736391 46072.818672990135 41499.0360748918 40147.48358251117 40301.73841536288 40009.47782214266 1.019712696593091 1.3081188969795803 1.2568798182439886 1.1358415484627333 1.1938019718650255 1.151547612738195 1.0372301348038282 1.003449326706587 1.0073047839944183 1.0 15.288054179232182 -7.244336377088418 2.1004842224319975 1.0025669276377747 1.1922265382483639 0.5696950839606507 0.07115721189593167 0.2357005366244924 2.0334049781474217 0.03493157970263207 0.02277379284681269 5.697228300089687e-08 7.244336377088418 0.18965961061058922 ST(ph)GGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R2 1 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 S(0.178)T(0.822)GGAPTFNVTVTK 117.0 0.0060090000000000005 4459300.0 25445.0 23982.0 27749.0 31528.0 28832.0 21008.0 26784.0 29850.0 24113.0 25083.0 True False 24030.868764405495 25821.342285716066 25963.659550826807 27233.832011166396 25209.86639864964 23901.661308363407 28029.50907148913 29936.85855806647 28936.27377351254 24358.788616539354 0.9865379244716954 1.0600421347793811 1.0658846775819453 1.1180289972496793 1.0349392490533136 0.9812335779347597 1.1506938835397338 1.228996196376517 1.1879192446321047 1.0 14.572154768115254 -7.368602088216096 7.200746675373179 1.1624788643481396 1.046493257720714 0.333495158435414 0.06721677398001903 0.2705163844589169 16.044383961228206 0.027821418509548765 0.018660330687088025 4.279548097920251e-08 7.368602088216096 -0.11598560662742563 ST(ph)PAMMNGQGSTTSSSK ddPTM_A459_Selumetinib_30min_R1 1 STPAMMNGQGSTTSSSK 17 0 Q6ZN18-2;Q6ZN18;F5GZR7;A0A669KBC9;A0A669KBL4;G5EA50;Q6ZN18-3 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.197)T(0.803)PAMMNGQGSTTSSSK 154.51 0.00018759 5212900.0 1279.3 1648.4 1770.2 1644.3 1732.4 1669.7 1798.5 1672.3 1175.4 1234.1 True False 1309.1052009155271 1455.4045616796302 1529.816563012574 1357.1538723337515 1575.7047258800621 1652.904333966302 1662.8376970193424 1627.9451716040426 1994.5679521805987 1392.5087561519672 0.9401055434172523 1.0451672603492046 1.098604627262841 0.9746106560105843 1.13155821743939 1.1869974437603588 1.194130873269621 1.1690735619520813 1.4323557703811864 1.0 10.443470683981293 -6.534222397909773 2.490336901120602 1.208915352684945 1.0222847867881621 0.3914082244607363 0.10581374681718154 0.2950270745783021 3.689695854319117 0.036210582476984235 0.03852066969734835 2.922655331669357e-07 6.534222397909773 -0.18663056589678284 ST(ph)PAMMNGQGSTTSSSK ddPTM_A459_Selumetinib_30min_R2 1 STPAMMNGQGSTTSSSK 17 0 Q6ZN18-2;Q6ZN18;F5GZR7;A0A669KBC9;A0A669KBL4;G5EA50;Q6ZN18-3 Q6ZN18-2 AEBP2 Zinc finger protein AEBP2 1 S(0.151)T(0.849)PAMMNGQGSTTSSSK 145.33 0.0011197000000000002 3319500.0 16366.0 15090.0 16535.0 15924.0 15726.0 11793.0 11974.0 15597.0 9096.4 13967.0 True False 15456.443238288872 16247.354478002479 15471.156101946784 13755.1237295678 13750.35928777623 13417.378703804725 12530.814726030872 15642.384687777654 10915.934174651826 13563.73641937588 1.1395416985698166 1.1978524188064459 1.1406264191219568 1.014110220390196 1.0137589571656491 0.9892096313990529 0.9238468176166065 1.1532504174463618 0.8047881378068028 1.0 13.72746703377373 -5.765040935581949 2.768789711463988 0.9870984188020698 1.1709738212218852 0.4890872834536767 0.08214672753756751 0.21602339186234487 3.3824379495200767 0.022474588991215835 0.03993473574364873 1.717746468762745e-06 5.765040935581949 0.18387540241981537 ST(ph)PEHTWSSR ddPTM_A459_Selumetinib_30min_R2 1 STPEHTWSSR 10 0 O14646;O14646-2 O14646 CHD1 Chromodomain-helicase-DNA-binding protein 1 1 S(0.029)T(0.967)PEHT(0.003)WS(0.001)SR 118.23 0.013507 6152000.0 17948.0 15150.0 20580.0 24272.0 24248.0 16130.0 18326.0 25067.0 17891.0 24370.0 True False 16950.522011536636 16311.95628507206 19255.905205809784 20966.111728464562 21201.74946012959 18351.761086438582 19178.19531228009 25139.940819934753 21469.699916307083 23666.37477913583 0.7162280733625558 0.6892460901723152 0.8136398322731585 0.8859029709505063 0.8958596176217475 0.7754360884463561 0.8103562751481271 1.0622641217571698 0.907181607519994 1.0 14.530551110179836 -2.6446987127127315 0.17710128050564122 1.0289159334886893 1.66527994316289e-12 0.6019199223170888 0.07084857769370102 28.72534680246775 0.4533145940510385 0.1895558199806971 7.322359810087337 0.0022662159261502266 2.6446987127127315 -1.028915933487024 ST(ph)PKEDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.445)T(0.555)PKEDDSSASTSQSTR 145.04 0.0050948 5283100.0 1869.2 2007.2 2372.9 2286.0 1688.3 1799.6 1648.2 1763.2 1255.3 1538.1 True False 1912.74872316994 1772.1960908780363 2050.6732134066983 1886.7930135346064 1535.593563093575 1781.4976579060653 1523.8749470265675 1716.4342083192296 2130.1524165154888 1735.5301173627256 1.1021120890005136 1.0211266708358986 1.1815831905716838 1.087156595358735 0.8847979921126521 1.0264861670122964 0.8780458096239869 0.9889970742354424 1.2273785370849242 1.0 10.761160685721958 -6.03463111353817 24.409680683326393 0.9946636311932457 1.1003610501715941 0.19361805869702686 0.09683896528103748 731.8547191782752 515845.59461757523 0.028836476403395924 0.03724935352711852 9.233553852731232e-07 6.03463111353817 0.10569741897834839 ST(ph)PKEDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R2 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 S(0.292)T(0.695)PKEDDS(0.012)SASTSQSTR 77.357 0.02766 13582000.0 41650.0 40478.0 35330.0 38769.0 34560.0 24027.0 32659.0 27578.0 20970.0 37216.0 True False 39335.25973816027 43582.53244271599 33056.906264395504 33488.59531974467 30218.263829679956 27336.501154610032 34177.70821258079 27658.24741421634 25164.585950755114 36141.47738121949 1.0883688932594766 1.20588685357293 0.9146528769621673 0.926597298901418 0.8361103645802408 0.7563747565232387 0.9456643914158541 0.7652771667986278 0.6962799468687909 1.0 15.141367861042351 -5.492509135978944 1.6971911958327366 0.8288285123616115 1.1579040331491417 0.599323026205027 0.0948622215082799 0.25444151091621064 1.3914632945134127 0.027829105150229166 0.08520228063472575 3.2172948517822757e-06 5.492509135978944 0.3290755207875302 ST(ph)PPYLFPEYPEASK ddPTM_A459_Selumetinib_30min_R2 2 STPPYLFPEYPEASK 15 0 Q8TE76-2;Q8TE76-3;Q8TE76 Q8TE76-2 MORC4 MORC family CW-type zinc finger protein 4 1 S(0.33)T(0.67)PPYLFPEYPEASK;S(0.453)T(0.541)PPY(0.006)LFPEYPEASK 187.08 5.444e-05 18358540.0 70416.0 50479.0 63744.0 70548.0 65646.0 47206.0 59937.0 59928.0 48598.0 48998.0 True False 66502.56061758207 54350.57698443253 59642.780439219605 60939.24069791191 57398.96259731394 53708.198006597646 62724.18926291233 60102.38055838553 58318.9579415735 47583.30042790718 1.3976029409380546 1.14221957064072 1.2534393348688282 1.2806854537179515 1.2062837609231907 1.1287194777077352 1.3181975335642155 1.2630981881857026 1.2256181773252943 1.0 15.538167721632778 -8.594276825815983 15.446970848841787 0.9999999990839769 1.2434063590816042 0.49451178627306003 0.07484544052256702 313.69863844453454 67870.06897874402 0.06956491979249785 0.017962639932977385 2.545207382062573e-09 8.594276825815983 0.2434063599976274 ST(ph)PSSSTPSSR ddPTM_A459_Selumetinib_30min_R2 1 STPSSSTPSSR 11 0 H3BUV9;Q96S82 H3BUV9 UBL7 Ubiquitin-like protein 7 1 S(0.019)T(0.981)PSSSTPSSR 130.01 0.0057916 2984600.0 13746.0 11642.0 13252.0 14306.0 18681.0 15373.0 21537.0 20305.0 15913.0 17030.0 True False 12982.052349597869 12534.9039650699 12399.380747686651 12357.498120773489 16334.125769741057 17490.4912078004 22538.513174755895 20364.084188326306 19096.044646369395 16538.29965074613 0.7849689885750849 0.757931844855912 0.7497373375458977 0.7472048748503586 0.9876544816990385 1.0575749367929317 1.3628071597879814 1.231328771298903 1.1546558624306866 1.0 14.013523294135037 -6.598572489395752 1.8477602754452065 1.2022715586465536 0.7564834296017773 0.8116378857800063 0.09115591924032941 0.13241758598209996 0.9231382722403815 0.03482433876960662 0.035862177365090224 2.5201564976447555e-07 6.598572489395752 -0.44578812904477627 ST(ph)SATDTHHVEMAR ddPTM_A459_Selumetinib_30min_R2 1 STSATDTHHVEMAR 14 0 H3BQP2;H3BNP3;H3BTL2;H3BS02;O14874-2;O14874-3;O14874 H3BQP2 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 1 S(0.394)T(0.589)S(0.017)ATDTHHVEMAR 135.61 0.00047082 8621500.0 23691.0 23097.0 24679.0 29530.0 29122.0 22257.0 35011.0 29891.0 26105.0 23546.0 True False 22374.34906258716 24868.465631439572 23091.180008463532 25507.963057908648 25463.43400601675 25322.699721070272 36639.080872980354 29977.977861278567 31326.72943464291 22866.16580014494 0.978491508289743 1.087566050591741 1.0098404870447133 1.1155330229323783 1.1135856456466062 1.1074309502693171 1.6023272634867414 1.3110190017553598 1.3700035986988401 1.0 14.4809268544001 -7.033548153581459 23.227118819676065 1.3479163924030997 1.0674502623057478 0.4260082434655663 0.14272266325775373 227.2851219472421 157360.24466109322 0.05129503856773093 0.03977163946276685 9.256607442788918e-08 7.033548153581459 -0.2804661300973519 ST(ph)SDTDLVTSDSR ddPTM_A459_Selumetinib_30min_R1 1 STSDTDLVTSDSR 13 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(0.011)T(0.495)S(0.495)DTDLVTSDSR 242.4 1.2769e-17 28481000.0 5091.4 4862.9 6603.2 6686.2 5720.8 5041.8 4914.6 5013.9 2977.9 4430.5 True False 5210.0197138601725 4293.549407299125 5706.521708781286 5518.58068551841 5203.3546500892735 4991.084069588129 4543.887765232839 4880.915084557501 5053.2788027893575 4999.197831724567 1.042171142097587 0.8588476695306104 1.1414874747640693 1.1038932387307971 1.040837915448983 0.9983769871868345 0.9089233749458041 0.976339654650902 1.010817929772972 1.0 12.287480904142145 -6.937028307777319 4.77534866184017 0.969697697521346 1.0364302818203657 0.14251286682633613 0.07320113730663733 0.42761143574082033 19.464147186127672 0.02812213459839125 0.024446695659346908 1.1560368880195151e-07 6.937028307777319 0.06673258429901963 ST(ph)SFRGGMGSGGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R1 2 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.071)T(0.308)S(0.308)FRGGMGS(0.308)GGLAT(0.007)GIAGGLAGMGGIQNEK;S(0.247)T(0.283)S(0.283)FRGGMGS(0.175)GGLAT(0.012)GIAGGLAGMGGIQNEK 71.117 0.00024434 460914300.0 1710.5 1779.74 3092.51 4020.8 2910.1 1981.3899999999999 1428.27 1402.23 846.72 1130.9499999999998 True False 1750.3513219463844 1571.3672134213216 2672.5641279414835 3318.6427597637576 2646.8819688198855 1961.4590155581795 1320.5344439932267 1365.0383053150383 1436.8219980180002 1276.1184488858812 1.3716213596586848 1.2313647019155691 2.094291584197982 2.60057580286619 2.0741663684360594 1.537050904068221 1.0348055426564227 1.0696799395908654 1.125931530315561 1.0 10.317546530449228 -7.069735947305003 3.3771881915378756 1.0658089047028243 1.8886077018193284 0.5309787373024244 0.360683158318616 0.233740411801418 5.191947707201489 0.16800693457699925 0.13075225367185433 8.516556907147029e-08 7.069735947305003 0.822798797116504 ST(ph)SFRGGMGSGGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R2 2 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.113)T(0.417)S(0.417)FRGGMGS(0.027)GGLAT(0.026)GIAGGLAGMGGIQNEK;S(0.306)T(0.329)S(0.273)FRGGMGS(0.075)GGLAT(0.017)GIAGGLAGMGGIQNEK 78.257 3.4107e-05 49083000.0 101668.0 161784.0 166524.0 149779.0 148348.0 50058.9 38848.3 38317.0 31944.2 144436.0 True False 96017.6995692504 174192.31258244885 155810.02713762256 129378.84181681332 129711.19799205309 56954.05908554995 40654.82292644606 38428.496126279184 38333.932595522725 140265.75739020357 0.6845412690578496 1.2418733967825477 1.110820131988284 0.9223836538870704 0.9247531286713914 0.4060439279353845 0.2898413959534608 0.2739691913499275 0.27329501732117006 1.0 17.09780332606762 -6.729346869192301 4.104521231054626 0.3883757022164381 1.0060501969789666 0.5368871010103035 0.24244242508705527 0.1448332306844462 5.314854040743594 0.08106894880760344 0.07760102641775671 1.8648896162931444e-07 6.729346869192301 0.6176744947625286 ST(ph)SPSAAGGQQK ddPTM_A459_Selumetinib_30min_R2 1 STSPSAAGGQQK 12 0 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 S(0.085)T(0.842)S(0.073)PSAAGGQQK 112.02 0.015322 4983400.0 37663.0 22195.0 32652.0 32004.0 32527.0 29966.0 69922.0 118500.0 53445.0 65989.0 True False 35569.84123693473 23897.285131826695 30551.20586880958 27644.99999002062 28440.667464930528 34093.544495735805 73173.51154781447 118844.81538126901 64135.49337806902 64083.726109987416 0.5550526381048119 0.37290723530669223 0.47673891209718827 0.4313887732210403 0.4438048345709109 0.5320156389973452 1.141842336418238 1.8545241139270632 1.0008078067744182 1.0 15.967670414376533 -7.30431479767408 3.6416845893353607 1.3469006568450952 0.45515351041935387 0.7356585503892685 0.22918406733432584 0.10654584780800488 2.9624196292638705 0.09470431376166141 0.06355468218257977 4.962324977095566e-08 7.30431479767408 -0.8917471464257414 ST(ph)VLGLPQHVQK ddPTM_A459_Selumetinib_30min_R2 3 STVLGLPQHVQK 12 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 S(0.042)T(0.958)VLGLPQHVQK;S(0.015)T(0.985)VLGLPQHVQK;S(0.211)T(0.789)VLGLPQHVQK 126.32 0.0064352 30424400.0 168053.0 119329.0 133385.0 170736.0 122839.0 132630.0 180467.0 151595.0 126679.0 115898.0 True False 158713.28702946103 128481.15059678945 124803.15431860734 147481.46226397203 107406.86662540675 150898.5786047335 188859.07308857658 152036.1163520967 152018.33970699614 112551.72360083216 1.4101364417335993 1.1415298361174053 1.1088515602055569 1.310343880534599 0.9542889543506966 1.3407042893443333 1.6779758412085324 1.350811089231268 1.3506531472244123 1.0 16.780228624621444 -6.980768925459117 24.953519639118642 1.393415150066578 1.1815584834605484 0.12776610051007764 0.19151176251090887 356.11857922713364 462084.5256838782 0.06493089998944362 0.057255900105784865 1.0452762301519965e-07 6.980768925459117 -0.21185666660602953 ST(ph)Y(ph)VT(ph)EVRELK ddPTM_A459_Selumetinib_30min_R2 1 STYVTEVRELK 11 1 Q86UP2-2;Q86UP2-3;Q86UP2-4;Q86UP2;H0YJP2;B7Z6P3;G3V4Y7 Q86UP2-2 KTN1 Kinectin 3 S(0.416)T(0.584)Y(1)VT(1)EVRELK 80.014 0.044391 5806000.0 0.0 1691.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 1821.4479503271568 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 STAALSGEAASCS(ph)PIIMPYK ddPTM_A459_Selumetinib_30min_R2 2 STAALSGEAASCSPIIMPYK 20 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 STAALSGEAAS(0.138)CS(0.862)PIIMPYK;STAALSGEAAS(0.018)CS(0.927)PIIMPY(0.055)K 132.13 0.00014777 13125300.0 82578.0 72673.0 86091.0 83339.0 104753.0 79944.0 70446.0 72719.0 58260.0 85587.0 True False 77988.64534592553 78246.78541947488 80551.9987887937 71988.08443220636 91592.99163629817 90955.56034062293 73721.87858610082 72930.6002507215 69913.62792040977 83115.88092826826 0.9383122030942834 0.9414179883024332 0.96915292106827 0.866117084102549 1.1019914679764502 1.0943222802284989 0.8869770465372945 0.8774568642743859 0.8411584782545651 1.0 16.342836538223608 STADS(ph)GGEGLETAPK ddPTM_A459_Selumetinib_30min_R1 3 STADSGGEGLETAPK 15 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 S(0.002)T(0.002)ADS(0.996)GGEGLETAPK;ST(0.002)ADS(0.998)GGEGLETAPK;STADS(1)GGEGLETAPK 228.76 8.8322e-14 34037100.0 8208.0 8707.3 10702.0 10707.8 8242.0 8153.0 8589.8 7260.8 4581.04 6574.4 True False 8399.23043001223 7687.84526808605 9248.72718187808 8837.883740300033 7496.512555243291 8070.988222331708 7941.864470312349 7068.219997597701 7773.690294076411 7418.2882800789985 1.1322329509042464 1.0363368175824224 1.2467468009722034 1.1913642887178169 1.0105447877206868 1.0879852491046302 1.0705791107686333 0.9528100999496922 1.0479088976565936 1.0 12.856870617771163 -6.267530768834402 24.949336323915713 1.0310429415165168 1.1502233004923648 0.4971036608896363 0.060743202463516575 452.8671476161073 1854865.8689862934 0.019736885223012236 0.022950258603322088 5.400938489160408e-07 6.267530768834402 0.119180358975848 STADS(ph)GGEGLETAPK ddPTM_A459_Selumetinib_30min_R2 1 STADSGGEGLETAPK 15 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 ST(0.002)ADS(0.998)GGEGLETAPK 188.0 2.4421e-05 7000100.0 43856.0 43223.0 50337.0 48759.0 52400.0 37766.0 34236.0 38720.0 32183.0 40940.0 True False 41418.65908947795 46538.06511614985 47098.37222278167 42117.94008603346 45817.0435380564 42967.923694385594 35828.04183734701 38832.66878955892 38620.4992681522 39757.95582510548 1.0417703382859491 1.170534655274279 1.1846276108853924 1.0593587927736905 1.1523993773624766 1.080737749279684 0.9011540229823161 0.9767269967395488 0.971390466804759 1.0 15.278955961479905 -7.095514719274718 4.957014314352132 0.961341524712582 1.123955826375985 0.7109380527589677 0.04817630561290759 0.11982760487272215 4.737445314961775 0.018453571281569846 0.014294113738509506 8.025743592544615e-08 7.095514719274718 0.16261430166340296 STAGDTHLGGEDFDNR ddPTM_A459_Selumetinib_30min_R1 7 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;E9PN89;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 ;;;;;; 145.7 0.0005168999999999999 743935600.0 30607.91 34242.18 40157.1 40887.3 33740.729999999996 30566.2 30963.9 32781.14 23587.36 29963.16 False True 31321.01475037472 30233.0896468424 34703.98638716089 33747.100604677864 30688.886928909713 30258.731779889054 28628.26809382108 31911.67767905053 40026.02716738692 33809.223451893966 0.926404440934302 0.8942260886251964 1.0264650543228258 0.9981625473502964 0.9077075364530606 0.8949845246502988 0.8467591139605825 0.9438749081136574 1.1838789265402276 1.0 15.045129259579392 -8.15634291492532 7.3496942325216 1.0906793108150332 0.9287026312382531 0.5079929011094466 0.06392090948357247 0.20390269850230333 12.26035012079722 0.044966573013420975 0.016797166709133962 6.976813037984826e-09 8.15634291492532 -0.16197667957678008 STAGDTHLGGEDFDNR ddPTM_A459_Selumetinib_30min_R2 6 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;E9PN89;P54652 P11142;P54652 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 ;;;;; 212.68 6.682999999999998e-38 821949800.0 778558.0 638155.0 838116.0 976155.0 964448.0 781267.0 723088.0 733231.0 691352.0 820196.0 False True 735288.8631746128 687099.4365082617 784192.5290317062 843201.0050386983 843285.4199654853 888879.4376142969 756713.0247716903 735364.5808170732 829641.7179888614 796514.810354865 0.9231326946036638 0.8626323422688696 0.9845297524126776 1.0586130905250004 1.0587190708855532 1.1159609665240016 0.9500300746882004 0.9232277557895653 1.041589820055245 1.0 19.603341661833184 -5.415925973177702 4.518979709289725 1.0206520073788599 0.8943560697773365 0.46527818952964184 0.054133778790314675 0.20895556542123725 6.877345127146153 0.015847809194861465 0.03431674718562835 3.8377265513993896e-06 5.415925973177702 -0.12629593760152336 STAPETAIECTQAPAPAS(ph)EDEKVVVEPPEGEEKVEK ddPTM_A459_Selumetinib_30min_R1 2 STAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEK 36 2 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y6G9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 STAPETAIECT(0.016)QAPAPAS(0.984)EDEKVVVEPPEGEEKVEK;STAPETAIECT(0.006)QAPAPAS(0.994)EDEKVVVEPPEGEEKVEK 117.01 3.0518e-23 55593000.0 4687.1 6011.8 8403.2 8700.6 5599.299999999999 7087.6 5699.9 5443.7 3289.5 4713.5 True False 4796.300310491028 5307.935661190001 7262.091595473542 7181.203540489594 5092.844303636703 7016.305179025911 5269.951953984185 5299.315392370344 5582.041244425795 5318.523638378003 0.9018104715905261 0.9980092262612881 1.365433734856591 1.350224992640938 0.9575672968504235 1.3192204559169134 0.9908674497480223 0.9963884251883259 1.0495471344991818 1.0 12.376810110240665 STAPETAIECTQAPAPAS(ph)EDEKVVVEPPEGEEKVEK ddPTM_A459_Selumetinib_30min_R2 1 STAPETAIECTQAPAPASEDEKVVVEPPEGEEKVEK 36 2 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y6G9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 STAPETAIECT(0.019)QAPAPAS(0.981)EDEKVVVEPPEGEEKVEK 84.809 1.8446e-09 9274600.0 24386.0 22042.0 22423.0 19650.0 17242.0 13858.0 13684.0 15764.0 10700.0 21841.0 True False 23030.72374489259 23732.550523799233 20980.328592316473 16973.636101859298 15075.905814564287 15766.813709601107 14320.333114331594 15809.87063012931 12840.298982979479 21210.393580266962 1.0858225547648097 1.1189113692769357 0.9891531957160602 0.8002508787791038 0.7107791638807739 0.7433531890831919 0.6751564066993306 0.7453831806703476 0.605377685915523 1.0 14.372483771329332 -5.700791144247938 2.147588386506366 0.7299066327471504 1.1036599819835309 0.6926688721578156 0.09670754864041842 0.1530885751680106 1.4340687972057948 0.026825285007373634 0.0546635711480334 1.9916309002335884e-06 5.700791144247938 0.3737533492363805 STAPSAAASASASAAAS(ph)SPAGGGAEALELLEHCGVCR ddPTM_A459_Selumetinib_30min_R1 3 STAPSAAASASASAAASSPAGGGAEALELLEHCGVCR 37 0 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 STAPSAAAS(0.001)AS(0.006)AS(0.148)AAAS(0.422)S(0.422)PAGGGAEALELLEHCGVCR;STAPSAAAS(0.009)AS(0.043)AS(0.131)AAAS(0.408)S(0.408)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.5)S(0.5)PAGGGAEALELLEHCGVCR 171.94 2.1664e-44 129738500.0 4122.73 4388.47 5637.49 5725.0 5245.070000000001 4693.8 4802.1900000000005 4328.41 2360.01 3762.4700000000003 True False 4218.78158756388 3874.6658922556467 4871.949822515962 4725.236221559768 4770.654344592323 4646.584633629409 4439.956942034651 4213.606506142829 4004.764601689415 4245.419674061333 0.9937254527131424 0.9126696981052501 1.147577906674952 1.1130198153153192 1.1237179621463735 1.0944935931821096 1.0458228592009173 0.9925064727727917 0.9433141854403058 1.0 12.051691460763163 -10.31625071459189 5.689976711102861 0.9999999938677767 1.0450103571781475 0.02283519519287147 0.07551985645095673 6.474407534373055e-09 1.2576930326299793e-09 0.08004122346244917 0.01941284541303523 4.827800166894698e-11 10.31625071459189 0.04501036331037078 STAPSAAASASASAAAS(ph)SPAGGGAEALELLEHCGVCR ddPTM_A459_Selumetinib_30min_R2 8 STAPSAAASASASAAASSPAGGGAEALELLEHCGVCR 37 0 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 STAPSAAASASASAAAS(0.5)S(0.5)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.5)S(0.5)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.554)S(0.446)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.5)S(0.5)PAGGGAEALELLEHCGVCR;STAPSAAAS(0.012)AS(0.031)AS(0.311)AAAS(0.323)S(0.323)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.5)S(0.5)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.556)S(0.444)PAGGGAEALELLEHCGVCR;STAPSAAAS(0.007)AS(0.02)AS(0.18)AAAS(0.614)S(0.18)PAGGGAEALELLEHCGVCR 178.06 1.4293999999999994e-50 513040800.0 166985.6 160552.59999999998 180290.1 199783.5 206717.4 156717.9 143581.69999999998 151941.19999999998 123747.70000000001 175558.6 True False 157705.20884832027 172866.4681620234 168690.43125101898 172572.6426542394 180747.71213499666 178304.3681815483 150258.53355174104 152383.32373678006 148500.69779963067 170489.76706197762 0.9250127533518782 1.0139404325608692 0.9894460773689453 1.0122170123647631 1.0601675118090226 1.045836188612598 0.881334616975094 0.8937974774837051 0.8710241110579187 1.0 17.379325624525123 -7.266238675687198 24.96171988237653 0.9026888371321191 1.0098014080466533 0.4934397079152113 0.04740132041436671 316.5559104998781 1646436.632228419 0.01938598389086747 0.013514252168174737 5.4170310422207974e-08 7.266238675687198 0.10711257091453419 STAPSAAASASASAAASS(ph)PAGGGAEALELLEHCGVCR ddPTM_A459_Selumetinib_30min_R1 6 STAPSAAASASASAAASSPAGGGAEALELLEHCGVCR 37 0 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 STAPSAAASASASAAAS(0.035)S(0.965)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.196)S(0.804)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.202)S(0.798)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.043)S(0.957)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.194)S(0.806)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.186)S(0.814)PAGGGAEALELLEHCGVCR 237.1 2.5599999999999998e-95 3066858900.0 18424.18 21382.3 22610.55 23176.559999999998 23338.100000000002 19345.93 21087.8 19541.82 9582.96 16879.100000000002 True False 18853.427546786403 18878.850375638427 19540.161500860908 19129.20887391322 21227.172975676207 19151.32750889902 19497.130268114808 19023.507452822643 16261.583208293852 19045.696901357 0.9899048401554211 0.991239673371748 1.0259620113700683 1.004384821043239 1.1145390523443528 1.0055461665744818 1.0237026436520493 0.9988349363822556 0.853819279626109 1.0 14.217177458090603 -8.052685579805543 9.112193376077983 0.9263343639444683 1.0225298157466673 0.3928417778267812 0.046718141209579934 0.442619397988214 73.05213008181234 0.030452270707477986 0.01155940540242039 8.857566471894628e-09 8.052685579805543 0.09619545180219902 STAPSAAASASASAAASS(ph)PAGGGAEALELLEHCGVCR ddPTM_A459_Selumetinib_30min_R2 10 STAPSAAASASASAAASSPAGGGAEALELLEHCGVCR 37 0 Q13263-2;Q13263 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 STAPSAAASASASAAAS(0.097)S(0.903)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.205)S(0.795)PAGGGAEALELLEHCGVCR;STAPSAAAS(0.004)AS(0.013)AS(0.046)AAAS(0.373)S(0.563)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.192)S(0.808)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.244)S(0.756)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.224)S(0.776)PAGGGAEALELLEHCGVCR;STAPSAAASASAS(0.006)AAAS(0.211)S(0.783)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.336)S(0.663)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.211)S(0.789)PAGGGAEALELLEHCGVCR;STAPSAAASASASAAAS(0.167)S(0.833)PAGGGAEALELLEHCGVCR 192.79 3.4345e-59 479271300.0 116287.6 116341.57 129682.06 144214.10000000003 133370.5 115000.7 104436.3 107280.5 101030.09 125527.3 True False 109824.80072814626 125264.59432189098 121338.45744675082 124571.89079680131 116615.30544260221 130841.00255258528 109292.79488660245 107592.6684937571 121238.93101657234 121903.00068990608 0.9009195844777926 1.0275759711652712 0.9953689143010406 1.0218935554645145 0.9566237482475548 1.0733206058267217 0.8965554110076325 0.8826088601990096 0.9945524747580006 1.0 16.895374113333126 -7.2869590323542255 24.98413610938234 0.9336465963222086 0.9967531680671994 0.17046989503816756 0.05507624932952908 1142.0813175023038 1118110.5351110087 0.022065690843057862 0.014883588751153538 5.164650858955997e-08 7.2869590323542255 0.06310657174499079 STAQQELDGKPAS(ph)PTPVIVASHTANK ddPTM_A459_Selumetinib_30min_R1 2 STAQQELDGKPASPTPVIVASHTANK 26 1 P35606;P35606-2;H0YAC7 P35606 COPB2 Coatomer subunit beta 1 STAQQELDGKPAS(0.888)PT(0.112)PVIVASHTANK;STAQQELDGKPAS(0.997)PT(0.003)PVIVASHTANK 131.5 3.1312e-09 188185000.0 11349.3 12235.0 8582.9 8732.0 8302.9 9253.7 10587.6 10934.2 5759.099999999999 10884.4 True False 11613.716608106464 10802.520512102816 7417.389322494986 7207.120119940594 7551.9041609960595 9160.616179687353 9788.968807874344 10644.189496712872 9772.772071978292 12281.518763034166 0.9456254419495981 0.8795752968775369 0.6039472369508891 0.5868264551802114 0.6148998594315831 0.7458862667099171 0.7970487198487141 0.8666834861459114 0.7957299305191075 1.0 13.58420135853221 -8.436810152374123 0.8108898469524886 0.9883776954824854 0.7239432325730194 0.3120312719236593 0.11445063304083238 0.8503999824538094 1.2571583735473209 0.1235794936019865 0.045892119816855315 3.6575464277101263e-09 8.436810152374123 -0.26443446290946604 STAQQELDGKPAS(ph)PTPVIVASHTANK ddPTM_A459_Selumetinib_30min_R2 3 STAQQELDGKPASPTPVIVASHTANK 26 1 P35606;P35606-2;H0YAC7 P35606 COPB2 Coatomer subunit beta 1 S(0.006)T(0.006)AQQELDGKPAS(0.728)PT(0.261)PVIVASHTANK;S(0.001)T(0.001)AQQELDGKPAS(0.786)PT(0.211)PVIVASHTANK;S(0.002)T(0.002)AQQELDGKPAS(0.877)PT(0.11)PVIVAS(0.009)HT(0.001)ANK 78.736 6.832600000000001e-05 800489000.0 362231.0 267715.0 317896.0 353531.0 318603.0 309922.5 384347.0 393845.0 351414.0 267227.0 True False 342099.65114558284 288247.8796605989 297442.917458995 305379.4679250081 278577.24279304186 352611.51117865834 402219.8970691326 394991.0237454503 421706.61932754755 259511.4621708707 1.3182448601069243 1.1107327485627867 1.1461648551891284 1.1767475138494514 1.0734679711743045 1.3587512020817314 1.5499118755852797 1.5220561760211404 1.6250019008789767 1.0 17.985438735763225 -6.941471676214302 4.895864337575166 1.4667932345263306 1.1630083912927134 0.3372665924894912 0.16993839086114393 0.19108975405269776 9.396010948679622 0.05804532174273189 0.05043737383665458 1.1442695042682162e-07 6.941471676214302 -0.3037848432336172 STAQQELDGKPAS(ph)PTPVIVASHTANKEEK ddPTM_A459_Selumetinib_30min_R1 2 STAQQELDGKPASPTPVIVASHTANKEEK 29 2 P35606;P35606-2;H0YAC7 P35606 COPB2 Coatomer subunit beta 1 STAQQELDGKPAS(0.824)PT(0.176)PVIVASHTANKEEK;STAQQELDGKPAS(0.689)PT(0.311)PVIVASHTANKEEK 104.01 4.0594e-09 577440000.0 6685.8 8112.299999999999 10371.0 9817.0 7783.8 8509.9 6976.2 7800.700000000001 5065.2 6808.5 True False 6841.566131697833 7162.508144694047 8962.675163825226 8102.64523791305 7079.756664341507 8424.298132370985 6449.979617429161 7593.800095755341 8595.274452429105 7682.4372954061 0.8905463030318403 0.9323223697480801 1.166644753375947 1.0546972173477058 0.9215508558169448 1.0965658173882524 0.8395746518212499 0.9884623595035704 1.1188212961489263 1.0 12.907348371149919 -5.017793446640986 24.727349108536533 1.0186256311371216 0.90099023307836 0.20050420236826139 0.09064945767680034 931.0392968108667 1293866.7802564846 0.023338991364741712 0.06486571895163427 9.598570373964751e-06 5.017793446640986 -0.11763539805876155 STAQQELDGKPAS(ph)PTPVIVASHTANKEEK ddPTM_A459_Selumetinib_30min_R2 8 STAQQELDGKPASPTPVIVASHTANKEEK 29 2 P35606;P35606-2;H0YAC7 P35606 COPB2 Coatomer subunit beta 1 STAQQELDGKPAS(0.696)PT(0.304)PVIVASHTANKEEK;STAQQELDGKPAS(0.79)PT(0.209)PVIVASHTANKEEK;STAQQELDGKPAS(0.5)PT(0.5)PVIVASHTANKEEK;STAQQELDGKPAS(0.5)PT(0.5)PVIVAS(0.001)HTANKEEK;STAQQELDGKPAS(0.499)PT(0.499)PVIVAS(0.001)HTANKEEK;S(0.001)T(0.001)AQQELDGKPAS(0.498)PT(0.498)PVIVASHTANKEEK;STAQQELDGKPAS(0.491)PT(0.491)PVIVAS(0.018)HTANKEEK;STAQQELDGKPAS(0.5)PT(0.5)PVIVASHTANKEEK 107.19 5.510800000000001e-11 742743700.0 1200772.0 1131957.0 1102652.0 1064757.0 1015009.0 813345.0 898646.0 930917.0 596100.5 993775.0 True False 1134037.8993111681 1218774.4620845728 1031708.5707967238 919735.2597917231 887494.4951244104 925375.8909392067 940434.8196332683 933625.8143483942 715337.2564395857 965082.1336124613 1.1750687944727332 1.2628712309930548 1.0690370641666205 0.9530124201439754 0.9196051446962057 0.9588571363096035 0.9744609156871095 0.9674055521613265 0.7412190439812212 1.0 19.88029220304864 -5.547242542537953 2.513483289153081 0.9301630604951049 1.2197680789577587 0.7270882116143378 0.07076986709956747 0.14180606723958705 1.787306630034288 0.019865239068344042 0.04446070173924469 2.8363345645708243e-06 5.547242542537953 0.28960501846265385 STAQQELDGKPASPT(ph)PVIVASHTANK ddPTM_A459_Selumetinib_30min_R2 3 STAQQELDGKPASPTPVIVASHTANK 26 1 P35606;P35606-2;H0YAC7 P35606 COPB2 Coatomer subunit beta 1 STAQQELDGKPAS(0.407)PT(0.593)PVIVASHTANK;S(0.058)T(0.058)AQQELDGKPAS(0.374)PT(0.507)PVIVAS(0.001)HTANK;STAQQELDGKPAS(0.159)PT(0.841)PVIVASHTANK 93.407 7.8731e-06 573896300.0 381474.0 259065.0 321205.0 359457.0 347768.0 304325.0 403137.0 421423.0 275572.0 292973.0 True False 360273.2022414153 278934.45247473294 300539.02000156103 310498.336502089 304078.2747546332 346243.0063627049 421883.6693008104 422649.2711596663 330694.10012501164 284514.10825472954 1.266275350812683 0.9803888256571057 1.0563237859982821 1.0913284350176948 1.068763431873078 1.2169625207222012 1.482821614326035 1.485512524325375 1.1623117818429465 1.0 18.118140667933446 -6.951946463217817 4.4730448963397365 1.3269419383202081 1.086030421379646 0.24165745429537 0.15131549203499065 0.22715781073014776 9.836280512576327 0.05400959939161278 0.04643974599725237 1.1170009353462907e-07 6.951946463217817 -0.24091151694056223 STAQQELDGKPASPT(ph)PVIVASHTANKEEK ddPTM_A459_Selumetinib_30min_R1 1 STAQQELDGKPASPTPVIVASHTANKEEK 29 2 P35606;P35606-2;H0YAC7 P35606 COPB2 Coatomer subunit beta 1 STAQQELDGKPAS(0.04)PT(0.959)PVIVAS(0.002)HTANKEEK 80.132 1.7865e-05 327110000.0 4332.4 4652.0 6219.1 6735.0 5668.2 4811.8 5452.3 4950.1 3112.6 3988.7 True False 4433.336490617082 4107.341677343873 5374.580379071012 5558.858681607867 5155.512310801991 4763.397660764842 5041.028621328087 4818.807267809112 5281.854864690599 4500.6884982281435 0.9850351768095976 0.912602967070677 1.1941684880406427 1.2351129574500235 1.145494142247712 1.0583708831749017 1.1200572142045973 1.0706822455511433 1.1735659703554222 1.0 12.135930000993385 -5.255888805275729 24.99339680206304 1.1293597559680584 0.9488190576691665 0.5199530830875093 0.06747191708904467 346.4756624779684 1560115.9195873525 0.017691257669378374 0.04416643845939272 5.547677349073131e-06 5.255888805275729 -0.18054069829889186 STAYEDYYYHPPPR ddPTM_A459_Selumetinib_30min_R2 1 STAYEDYYYHPPPR 14 0 O43390;B4DT28;O43390-4;O43390-3;O43390-2;A0A286YEZ8 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 107.93 0.0070938999999999985 4221500.0 15766.0 14356.0 14885.0 14071.0 15692.0 12989.0 13405.0 13759.0 12854.0 16519.0 False True 14889.788836298565 15457.059038184465 13927.315305562614 12154.5055261711 13720.630671740098 14778.116847597697 14028.35906150359 13799.036412074931 15425.159170768055 16042.053548483585 0.928172243740332 0.9635336892168386 0.8681753407361695 0.7576651885269411 0.8552914145481751 0.9212110409015954 0.8744740203681501 0.8601789272408531 0.9615451740108519 1.0 13.969571213024382 -8.413423742677766 3.7338855330140075 0.998682237965629 0.8776616095627008 0.388144414421131 0.0522190613356056 0.24991326994506297 5.95491148812545 0.05555420651002426 0.014680337032815653 3.859901812644251e-09 8.413423742677766 -0.12102062840292827 STCS(ph)CPDLQPNGQDLGENSR ddPTM_A459_Selumetinib_30min_R1 1 STCSCPDLQPNGQDLGENSR 20 0 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 S(0.002)TCS(0.997)CPDLQPNGQDLGENSR 208.52 1.0274e-16 3132200.0 401.13 485.94 548.82 565.85 616.15 430.68 500.66 352.41 207.86 219.26 True False 410.47554853689195 429.045918892623 474.2932584524694 467.03491982001657 560.4193412901179 426.34775022615247 462.89481311632153 343.0629420109916 352.72323850626117 247.40415677326 1.6591295550182812 1.7341904214076456 1.917078777650239 1.8877407959157408 2.265197758191787 1.7232845065610194 1.8710066118272763 1.3866498707432817 1.4256964923573356 1.0 7.950725929805212 -8.164382854072798 1.1104242191898217 1.0436802454085778 1.8876678544327905 0.7190575586857582 0.175489138720814 0.2537930851638384 0.6048100251908025 0.16840707436871102 0.057185112933540734 6.848841977903642e-09 8.164382854072798 0.8439876090242127 STCS(ph)CPDLQPNGQDLGENSR ddPTM_A459_Selumetinib_30min_R2 2 STCSCPDLQPNGQDLGENSR 20 0 F5H7V1;O43847;O43847-2 F5H7V1 NRD1 Nardilysin 1 S(0.003)T(0.003)CS(0.995)CPDLQPNGQDLGENSR;S(0.014)T(0.003)CS(0.983)CPDLQPNGQDLGENSR 233.46 2.7632e-24 10556000.0 19395.4 16711.8 21424.9 25260.0 27132.0 21046.5 20313.7 22094.0 16194.099999999999 23995.0 True False 18317.481313937908 17993.54132309356 20046.445259667344 21819.544424069507 23723.43559684249 23945.46433389522 21258.327300832934 22158.289882141402 19433.37250095961 23302.20200350283 0.786083706217309 0.7721820161197099 0.8602811552596585 0.93637264069677 1.0180769865987918 1.0276052164639073 0.9122883450086539 0.9509096985259388 0.8339715061279767 1.0 14.508178672172688 -5.573054829076583 2.401859161421277 0.9572540954209399 0.7789281531742204 0.6418211489688093 0.053054818165943735 0.19066148795818644 2.1987504556840447 0.016150782589004615 0.03583822915259706 2.67266896660917e-06 5.573054829076583 -0.1783259422467195 STDEYS(ph)EADEEEEEEEGKPSR ddPTM_A459_Selumetinib_30min_R2 2 STDEYSEADEEEEEEEGKPSR 21 1 Q96T23-3;Q96T23-2;Q96T23 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 S(0.006)T(0.006)DEY(0.002)S(0.987)EADEEEEEEEGKPSR;S(0.031)T(0.031)DEYS(0.937)EADEEEEEEEGKPSR 132.36 2.5684e-05 25990000.0 40582.0 34027.0 37680.0 44854.0 38770.0 31056.0 38625.0 44065.0 24405.0 34308.0 True False 38326.614902617526 36636.761485950294 35255.70982288206 38744.80782253421 33899.365991802406 35333.682101700986 40421.13903398551 44193.221854646574 29286.681932674233 33317.43889711089 1.1503469705752503 1.099627183202465 1.0581758679518205 1.1628987432732698 1.0174661412748016 1.0605161522413695 1.2132126709622515 1.3264291409409255 0.8790196036110631 1.0 15.023989884921388 STDS(ph)PIIIEPLSKPDYR ddPTM_A459_Selumetinib_30min_R1 1 STDSPIIIEPLSKPDYR 17 1 A0A0D9SEJ8;Q86YH2 A0A0D9SEJ8 ZNF280B Zinc finger protein 280B 1 S(0.014)T(0.014)DS(0.971)PIIIEPLSKPDYR 112.74 0.0010395 15689000.0 2339.2 2558.2 3184.1 2977.9 2517.0 2404.4 2073.1 2384.7 1413.1 2173.3 True False 2393.69880870914 2258.6847547250854 2751.7167090093412 2457.8656671061726 2289.3377944124436 2380.213919020528 1916.724397937615 2321.4500094027153 2397.9274912594915 2452.26422473468 0.9761178198357168 0.9210609248150906 1.1221126505269066 1.0022841920193566 0.9335608175175887 0.970618865215494 0.7816141419854514 0.9466557420637991 0.9778422190695755 1.0 11.25989871849391 -6.2746473451875255 4.60888321717359 0.9257804374998584 1.0082361866399931 0.17702706430892767 0.07284178696575655 0.3252225766087763 18.826661114325756 0.023325507781094417 0.02807444362668935 5.313157068766415e-07 6.2746473451875255 0.08245574914013476 STDS(ph)PVPGSEDDLVAGATLHSPEWSEER ddPTM_A459_Selumetinib_30min_R1 3 STDSPVPGSEDDLVAGATLHSPEWSEER 28 0 Q9H694;Q9H694-2 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.207)T(0.207)DS(0.583)PVPGS(0.004)EDDLVAGATLHSPEWSEER;S(0.205)T(0.205)DS(0.587)PVPGS(0.003)EDDLVAGATLHSPEWSEER;S(0.207)T(0.207)DS(0.567)PVPGS(0.019)EDDLVAGATLHSPEWSEER 166.77 6.781799999999998e-22 204387000.0 7250.0 9185.1 8920.7 9536.9 15281.0 7667.8 9999.400000000001 7877.900000000001 4208.1 5933.0 True False 7418.91089395574 8109.704221962853 7709.317937897569 7871.459444784867 13898.836248079675 7590.668893805364 9245.13720743688 7668.952500974405 7140.838352536313 6694.558342313931 1.1082002000137088 1.2113874892544123 1.1515797672819883 1.1757996632925225 2.0761393862579487 1.1338565601598296 1.3809928504172775 1.1455501780456037 1.0666630997001856 1.0 12.70877316495086 -8.003516041600772 2.349511915511288 1.026241412017241 1.3265287539010957 0.15857193037065498 0.2684897301519476 0.6178011734780986 6.360802563962625 0.22475156708752916 0.0770174001014656 9.919366992469477e-09 8.003516041600772 0.30028734188385475 STDS(ph)PVPGSEDDLVAGATLHSPEWSEER ddPTM_A459_Selumetinib_30min_R2 3 STDSPVPGSEDDLVAGATLHSPEWSEER 28 0 Q9H694;Q9H694-2 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.221)T(0.221)DS(0.558)PVPGSEDDLVAGATLHSPEWSEER;S(0.17)T(0.17)DS(0.584)PVPGS(0.077)EDDLVAGATLHSPEWSEER;S(0.083)T(0.083)DS(0.641)PVPGS(0.192)EDDLVAGAT(0.001)LHSPEWSEER 101.9 2.6353000000000003e-07 43622500.0 144516.0 137794.0 175213.0 169531.0 192928.0 131069.0 134317.0 142674.0 131575.0 161530.0 True False 136484.37926338473 148362.35672245687 163939.9863374902 146440.58534271273 168690.65984179656 149122.56502408048 140563.0066440863 143089.15771904768 157893.67651266555 156866.20919465818 0.8700687035409821 0.9457891376615807 1.0450943334396132 0.9335381156625765 1.0753792082300224 0.95063535856235 0.8960693789040256 0.9121732363755007 1.0065499595055067 1.0 17.259175086924103 -4.5990039639514775 0.003674573358738726 1.9080817951403455 4.0059446869946046e-05 0.0388840206660136 0.06173012978195219 338372.32209652266 183.79364448810279 46380.53251583074 49083.11480165744 2.5176539481815216e-05 4.5990039639514775 -1.9080417356934756 STDSEVSQS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 4 STDSEVSQSPAK 12 0 A0A0G2JNJ7;H7C148;H7C3F5;A0A2H2FJL5;B7Z6J7;O75175 A0A0G2JNJ7 CNOT3 CCR4-NOT transcription complex subunit 3 1 STDSEVS(0.012)QS(0.987)PAK;STDSEVSQS(1)PAK;STDSEVSQS(1)PAK;STDSEVS(0.002)QS(0.998)PAK 211.82 4.497e-06 520230000.0 31044.4 35604.9 37270.2 40436.2 30565.9 29352.399999999998 31196.3 29568.5 17261.9 26884.100000000002 True False 31767.67411811302 31436.261755731062 32209.11155055432 33374.77675148209 27801.21974184793 29057.141505846856 28843.137974714795 28784.247327975918 29292.183540706403 30334.936108309794 1.0472306255957713 1.0363055205881768 1.0617827390686716 1.100209231768897 0.9164753023571462 0.9578771289347497 0.9508224402296881 0.9488810929155348 0.9656253580399747 1.0 14.8886926523074 -6.262501774905819 24.99999960748616 0.9538312305470126 1.0596194731831343 0.8125096156343248 0.024627799356036244 38.767574771728825 912263.6961456926 0.007422169432450852 0.008913383654630755 5.463843168747e-07 6.262501774905819 0.10578824263612174 STDSEVSQS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 5 STDSEVSQSPAK 12 0 A0A0G2JNJ7;H7C148;H7C3F5;A0A2H2FJL5;B7Z6J7;O75175 A0A0G2JNJ7 CNOT3 CCR4-NOT transcription complex subunit 3 1 STDSEVS(0.003)QS(0.997)PAK;STDSEVS(0.001)QS(0.999)PAK;STDSEVSQS(1)PAK;STDSEVSQS(1)PAK;STDSEVS(0.001)QS(0.999)PAK 201.3 8.1357e-05 452519000.0 545360.0 473064.0 511902.0 514846.0 503657.0 395035.4 457138.0 460426.0 336512.1 460575.0 True False 515051.0744490539 509346.487659493 478966.7826367561 444723.0866411119 440383.10490929097 449447.9405756795 478395.8228017628 461765.7634323723 403823.9229336713 447277.00303243636 1.1515259469123715 1.1387719113798376 1.0708504559578744 0.994290078913046 0.9845869604821926 1.0048536757502056 1.0695739319445174 1.0323932603324237 0.9028497333773856 1.0 18.77080905780958 -5.466110720115111 2.3701983133530944 1.00219613334993 1.14891989293752 0.6849036083621276 0.03994184493968802 0.18258287928812286 1.9933590875600458 0.011785739764536788 0.02987973216923392 3.4189226853693297e-06 5.466110720115111 0.14672375958758987 STDSPVPGS(ph)EDDLVAGATLHSPEWSEER ddPTM_A459_Selumetinib_30min_R2 2 STDSPVPGSEDDLVAGATLHSPEWSEER 28 0 Q9H694;Q9H694-2 Q9H694 BICC1 Protein bicaudal C homolog 1 1 S(0.048)T(0.021)DS(0.126)PVPGS(0.803)EDDLVAGAT(0.002)LHSPEWSEER;S(0.029)T(0.029)DS(0.267)PVPGS(0.674)EDDLVAGATLHSPEWSEER 90.744 9.3734e-06 41346900.0 63450.0 53309.6 71351.0 77209.0 85376.0 59030.0 56273.5 57020.9 52332.8 70640.0 True False 59923.70301047469 57398.27490261896 66760.35434109511 66693.00100704587 74650.30360887598 67160.84667901241 58890.32925382485 57186.82137868181 62800.82230060453 68600.43965523806 0.8735177691517775 0.8367041842746594 0.9731767708284293 0.9721949500939306 1.0881898714358456 0.9790148141402512 0.858454108308739 0.8336217911442386 0.9154580147914446 1.0 16.06593020210496 -10.549202775438394 20.956511263388546 0.9999999999396317 0.9274221562567467 0.07937973679971677 0.07578906426239065 0.0 0.0 0.08304659327076136 0.020141757406062236 2.8235613245670815e-11 10.549202775438394 -0.072577843682885 STDSS(ph)SVSGSLQQETK ddPTM_A459_Selumetinib_30min_R2 1 STDSSSVSGSLQQETK 16 0 Q9H8G2;A0A3B3ISJ3 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 STDSS(0.939)S(0.06)VSGSLQQETK 342.28 1.1522999999999996e-153 4122900.0 22099.0 18026.0 19146.0 23710.0 21258.0 20561.0 18021.0 16783.0 12582.0 21171.0 True False 20870.826049306226 19408.53623727453 17914.167204588633 20480.657097968648 18587.37999106875 23393.091115825424 18859.01220793407 16831.835751424787 15098.751570453056 20559.73822113602 1.015130923595632 0.9440069726822679 0.8713227285244488 0.9961535928951627 0.904066958010213 1.1378107475987527 0.9172788099289341 0.8186794778408785 0.7343844268858974 1.0 14.327534274943439 -7.585612029944508 5.315720486542799 0.8355512710976756 0.9735617719408457 0.27493749621511965 0.09119042943998802 0.2433157046330127 13.541598615437257 0.04323860743157876 0.02458320945519546 2.5964978663623226e-08 7.585612029944508 0.13801050084317013 STDSSS(ph)VSGSLQQETK ddPTM_A459_Selumetinib_30min_R2 1 STDSSSVSGSLQQETK 16 0 Q9H8G2;A0A3B3ISJ3 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 STDSS(0.03)S(0.969)VSGSLQQETK 197.73 1.0279e-06 5007100.0 27347.0 26549.0 29675.0 32505.0 36417.0 29128.0 26220.0 29218.0 22840.0 31309.0 True False 25827.163218714748 28585.22293151012 27765.742807697054 28077.76292574739 31841.970887889285 33140.11760234244 27439.281953944344 29303.019542699723 27408.638202920683 30405.027819448635 0.8494372500522547 0.9401478959748074 0.9131957705342615 0.9234578929668794 1.047260047810958 1.089955181068583 0.9024587024515976 0.9637557221360603 0.9014508510131569 1.0 14.89202228908733 -6.037141077965957 15.226832717547174 0.9837083211552554 0.9070933040693252 0.30319944087942396 0.05814860399052646 8.285773650484378 3396.624643629036 0.018308368491318616 0.023707772563995203 9.180343300776424e-07 6.037141077965957 -0.07661501708593021 STEDLS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 1 STEDLSPQK 9 0 Q96RT1-7;Q96RT1-6;Q96RT1-4;Q96RT1-5;Q96RT1-3;Q96RT1-9;Q96RT1-2;Q96RT1;Q96RT1-8 Q96RT1-7 ERBB2IP Protein LAP2 1 STEDLS(1)PQK 95.094 0.022683 26109000.0 107140.0 64659.0 95382.0 93418.0 73350.0 58297.0 137370.0 86471.0 69260.0 76486.0 True False 101185.5877154021 69618.13738854625 89245.22596406934 80694.30724496146 64135.11724268007 66326.88258252382 143757.97719349086 86722.61629395527 83113.93528608953 74277.65044550595 1.3622615565854126 0.9372689762127282 1.2015084676048606 1.0863874498044752 0.8634510765756251 0.8929588131114184 1.9354136315735968 1.1675465738860389 1.1189629018632778 1.0 16.180640560140127 STELKTEIKEEEDQPSTSATQS(ph)SPAPGQSK ddPTM_A459_Selumetinib_30min_R2 1 STELKTEIKEEEDQPSTSATQSSPAPGQSK 30 2 A0A669KB12;Q09472 A0A669KB12 EP300 Histone acetyltransferase p300 1 STELKTEIKEEEDQPS(0.002)T(0.008)S(0.008)AT(0.033)QS(0.474)S(0.474)PAPGQSK 58.26 0.0014558 7081100.0 43794.0 64228.0 50750.0 48026.0 42437.0 25805.0 23259.0 22685.0 12085.0 48211.0 True False 41360.1048012723 69154.0810744297 47484.8002524221 41484.77595052897 37105.684668406466 29359.40451553302 24340.589586834147 22751.00959429609 14502.337683112806 46819.02316277871 0.8834038390222915 1.4770509165472605 1.0142202259822604 0.8860666700861354 0.7925343623552065 0.6270828080598199 0.5198867456548091 0.485935161765255 0.3097531025517469 1.0 15.514807213766217 -6.193427801406235 1.1239011778418038 0.5401054614439919 1.1856588139982052 0.5314013026616178 0.21712508693757032 0.3422346922445777 0.8927275640128158 0.08695520767720487 0.13964343354236455 6.40578264630397e-07 6.193427801406235 0.6455533525542133 STELVLS(ph)PDMPR ddPTM_A459_Selumetinib_30min_R1 1 STELVLSPDMPR 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 STELVLS(1)PDMPR 95.417 0.018056 5087800.0 1860.0 2094.4 2071.5 2154.4 1858.5 1810.6 1676.1 1910.3 1188.1 1457.2 True False 1903.3343810700246 1849.1866743398568 1790.201677935007 1778.1744830966566 1690.3990031448259 1792.387007893266 1549.6704275641478 1859.6326384710912 2016.118924609299 1644.2458143299953 1.1575728911589804 1.1246412538951007 1.0887676662047556 1.0814529479713075 1.0280695188107487 1.090096743608641 0.9424809928408512 1.1309942967553563 1.22616637186383 1.0 10.68321028234629 -5.107850955620149 1.5651907939711889 1.0704566154229516 1.1650615319948927 0.13609175953428787 0.0717986345876136 1.317327530368151 4.691884987786524 0.021600946683579335 0.15840655857595773 7.800977842942841e-06 5.107850955620149 0.09460491657194114 STES(ph)DVKADGDSK ddPTM_A459_Selumetinib_30min_R2 2 STESDVKADGDSK 13 1 Q9Y4W2-3;Q9Y4W2-2;Q9Y4W2;Q9Y4W2-4 Q9Y4W2-3 LAS1L Ribosomal biogenesis protein LAS1L 1 S(0.001)T(0.001)ES(0.999)DVKADGDSK;S(0.002)T(0.002)ES(0.995)DVKADGDSK 148.18 0.0026267 12807200.0 66563.0 50314.0 57126.0 58118.0 57558.0 44980.0 55468.0 55165.0 37381.0 59493.0 True False 62863.6949328011 54172.92201499115 53450.57535408599 50202.22814085793 50327.04946495131 51175.58671221378 58047.37190775683 55325.52101694261 44858.24451240707 57775.28250862243 1.088072480189418 0.9376487602099797 0.9251460665053257 0.8689222442722925 0.871082706647786 0.8857695625214171 1.0047094429887693 0.957598450664188 0.7764262252757032 1.0 15.818164788725992 -4.689006241367289 2.423796481836616 0.9093509298811832 1.1597134276342131 0.402556056790325 0.06422027785575544 0.8194575537899813 4.71361775671306 0.01671368919211706 0.47619476658190224 2.0464152269085994e-05 4.689006241367289 0.25036249775303 STETSDFENIES(ph)PLNER ddPTM_A459_Selumetinib_30min_R2 2 STETSDFENIESPLNER 17 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 1 STETSDFENIES(1)PLNER;ST(0.001)ETSDFENIES(0.999)PLNER 186.56 6.052500000000001e-08 24669000.0 50862.0 49497.0 57083.0 59254.0 58267.0 41036.0 43402.0 47214.0 43941.0 53519.0 True False 48035.29365671809 53293.26074206019 53410.34192727117 51183.50298114863 50946.978546410886 46688.33651228109 45420.278999431415 47351.384923301535 52730.42781412163 51973.76741093846 0.9242218921118373 1.0253876791476162 1.027640376826529 0.9847949365774953 0.9802440939790046 0.8983057961362063 0.873907766591348 0.9110631628627311 1.0145585059709163 1.0 15.665496018660752 -6.61351903736433 6.114874400446422 0.93011088414516 0.9941009617995215 0.18996739688608577 0.048620933709251066 0.28899365209143346 15.912996065299238 0.016463016541908536 0.016448960358785375 2.434899063443748e-07 6.61351903736433 0.06399007765436149 STFAGS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 STFAGSPER 9 0 Q2TBE0;H0YE03;H7C3G7;Q2TBE0-3;Q2TBE0-2 Q2TBE0 CWF19L2 CWF19-like protein 2 1 S(0.002)TFAGS(0.998)PER;S(0.005)T(0.007)FAGS(0.988)PER 107.34 0.012643 36938000.0 9019.3 11349.2 8180.299999999999 7498.9 8893.5 8039.3 10030.5 8833.7 5129.6 8815.8 True False 9229.432141497236 10020.430387900064 7069.460191171481 6189.357886786817 8089.084495274949 7958.431941100372 9273.891309398125 8599.401580098453 8704.556548839206 9947.393803163854 0.927824144105136 1.0073422834343786 0.7106846608327679 0.6222089935575125 0.8131863134544997 0.8000519632156439 0.9322935728601077 0.8644879000732171 0.8750590075232215 1.0 13.280102876674421 -8.502793313279112 0.7291563395489772 0.9941756058615351 0.8157343382272685 0.20122783120797838 0.10414607309106906 1.3455846973739518 1.6287786558268391 0.1145915503681141 0.0445415120681577 3.1420036608941598e-09 8.502793313279112 -0.1784412676342666 STFAGS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 STFAGSPER 9 0 Q2TBE0;H0YE03;H7C3G7;Q2TBE0-3;Q2TBE0-2 Q2TBE0 CWF19L2 CWF19-like protein 2 1 S(0.002)T(0.008)FAGS(0.99)PER;S(0.001)T(0.002)FAGS(0.997)PER 96.756 0.0212 78143000.0 97684.0 88644.0 118993.0 113706.0 128081.0 101367.0 102525.0 117278.0 93405.0 89353.0 True False 92255.11434003476 95442.70976461557 111337.11992978246 98219.0466462092 111990.319721332 115329.38413199129 107292.6156494335 117619.25956358196 112088.60995375665 86773.14672302526 1.0631758536371583 1.0999106678620638 1.2830826601824634 1.1319060141926 1.2906103322355988 1.3290907208899068 1.2364725690069207 1.3554799382695624 1.2917430586162426 1.0 16.404961027248973 -4.8989238479597725 0.9829851704966539 1.2635639696984302 0.9631501292448369 0.24664231587589502 0.10211384090805986 2.002642858077005 1.7599621143000932 0.032823538364315494 0.6137513171869381 1.2620488110983426e-05 4.8989238479597725 -0.3004138404535933 STFREES(ph)PLR ddPTM_A459_Selumetinib_30min_R1 1 STFREESPLR 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.005)T(0.001)FREES(0.993)PLR 80.87100000000002 0.025575 264020000.0 4786.7 6017.6 7758.8 9057.9 6279.6 5703.0 5478.6 4760.3 3351.2 3272.6 True False 4898.2207967031645 5313.056594493657 6705.197576037712 7476.1078028412585 5711.6112887534255 5645.632997909695 5065.344791153832 4634.0413803664005 5686.741638036092 3692.670087823455 1.3264712742291822 1.4388116100632469 1.8158127903567767 2.0245804864869066 1.5467429130989552 1.528875546322461 1.3717295806784253 1.2549297040228717 1.5400080437155945 1.0 11.85044865905987 -7.155186764104433 1.796849742273493 1.295293115313843 1.6517102544377484 0.3558333649085278 0.21797632441379566 0.45923338145471465 2.917380409241377 0.1172129504518238 0.07932591685745231 6.99541100483638e-08 7.155186764104433 0.3564171391239055 STFREES(ph)PLR ddPTM_A459_Selumetinib_30min_R2 1 STFREESPLR 10 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 S(0.013)T(0.013)FREES(0.975)PLR 69.86399999999999 0.041638 306380000.0 174470.0 239520.0 230610.0 235130.0 200210.0 111140.0 97947.0 114540.0 79652.0 179040.0 True False 164773.65585874737 257890.41382181307 215772.80366918308 203104.88837812626 175057.8298998907 126448.52617153026 102501.7295782985 114873.29243688217 95584.62566283013 173870.64999821442 0.9476795299289416 1.4832314356934968 1.2409961294295442 1.1681378563904377 1.006827948832586 0.7272563033084011 0.5895286500588292 0.6606824811321628 0.5497456049299393 1.0 17.40765489543289 -6.568711480337539 1.9065338369721234 0.6660461174434337 1.2403466118026365 0.6696154548724988 0.16700722164779255 0.17913365940437423 1.3225553981867324 0.060747960386078444 0.06383556268664767 2.6995322470105915e-07 6.568711480337539 0.5743004943592028 STFS(ph)LPEEEEEPEPLVFAEQPSVK ddPTM_A459_Selumetinib_30min_R1 1 STFSLPEEEEEPEPLVFAEQPSVK 24 0 H3BR17;Q6Q0C0;Q6Q0C0-2 H3BR17 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 S(0.171)T(0.171)FS(0.659)LPEEEEEPEPLVFAEQPSVK 136.3 5.2171e-08 3947500.0 1615.4 1531.8 1499.7 1807.7 1774.9 1602.0 1793.1 1606.7 871.97 1331.6 True False 1653.035676978772 1352.4561438854992 1296.0489772624323 1492.0191297316317 1614.3606083840466 1585.8853344996207 1657.8450233669075 1564.0850967028746 1479.6694038309658 1502.5238308823918 1.1001726847872946 0.9001229239014719 0.8625813119391907 0.9930086292577529 1.0744326147798775 1.0554809859942607 1.1033735301178549 1.0409719064384686 0.9847893081083418 1.0 10.55317215774377 -6.002324821431892 24.983763678599455 1.0474733105022016 0.945361962986104 0.2690465043668726 0.0655794141157334 108.65326934979085 1167678.5356400476 0.01880576313903511 0.027392786969191375 9.946612031305e-07 6.002324821431892 -0.10211134751609763 STFS(ph)PAPRPEMPGTVEVESTFLAR ddPTM_A459_Selumetinib_30min_R1 2 STFSPAPRPEMPGTVEVESTFLAR 24 1 Q92576-2;Q92576;E7EVH3;E7ER40 Q92576-2 PHF3 PHD finger protein 3 1 S(0.118)T(0.118)FS(0.506)PAPRPEMPGT(0.206)VEVES(0.026)T(0.026)FLAR;S(0.081)T(0.081)FS(0.787)PAPRPEMPGT(0.013)VEVES(0.019)T(0.019)FLAR 47.54600000000001 0.031368 12895300.0 1033.3899999999999 1292.79 1107.26 1412.98 1483.15 1206.51 1393.4299999999998 1175.1599999999999 531.36 1164.71 True False 1057.4659763730926 1141.4295457982341 956.9001737438155 1166.229567919567 1348.9993443713997 1194.3736048234312 1288.322453243071 1143.9909393423472 901.6791110010925 1314.21187373613 0.8046388847232503 0.8685277987584311 0.7281171269770035 0.8873984410170721 1.0264702148340614 0.9088135853072042 0.9803004211037458 0.8704767946511797 0.6860987402569559 1.0 10.359982166522862 -5.977707969535103 22.072636827788553 0.9131790213492456 0.8073242722339272 0.219940444359504 0.09397494628531057 101.63912773394998 100635.13090173643 0.02714511226422149 0.04025528974306532 1.0526694771595713e-06 5.977707969535103 -0.10585474911531834 STFS(ph)PISDIGLAK ddPTM_A459_Selumetinib_30min_R1 1 STFSPISDIGLAK 13 0 Q8TEK3-1;Q8TEK3;H7C2S2 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 STFS(0.992)PIS(0.008)DIGLAK 155.09 0.00036711 15650000.0 1339.3 1709.3 1667.0 1676.5 1378.0 1241.2 1296.1 1499.2 769.28 1021.8 True False 1370.50308417585 1509.1743613679887 1440.630556175552 1383.7307468026104 1253.36014330566 1228.7146549194317 1198.3341335039029 1459.4363459120864 1305.4119740118188 1152.9579831748472 1.188684326901453 1.3089586814015937 1.249508288418763 1.2001571323460503 1.0870822368169393 1.0657063595118852 1.0393562913750816 1.2658191948099478 1.1322285747284269 1.0 10.171124223003204 -6.0606785358383295 3.192022492564578 1.107343054329593 1.2536781028157167 0.4770457507904391 0.07179933289468707 0.24089107438972632 4.8466345048779935 0.022718175062674904 0.031940617042243616 8.696038706756913e-07 6.0606785358383295 0.14633504848612366 STFS(ph)TNYR ddPTM_A459_Selumetinib_30min_R1 6 STFSTNYR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 ST(0.001)FS(0.776)T(0.223)NYR;S(0.004)T(0.005)FS(0.728)T(0.263)NYR;ST(0.002)FS(0.775)T(0.223)NYR;S(0.022)T(0.074)FS(0.859)T(0.046)NYR;S(0.337)T(0.005)FS(0.572)T(0.086)NYR;S(0.008)TFS(0.496)T(0.496)NYR 122.94 0.0061569 549337000.0 13425.35 22222.8 19146.0 21819.2 19126.899999999998 17957.7 19642.09 16616.999999999996 8785.980000000001 14023.73 True False 13738.134533816374 19620.94424490056 16546.07836144997 18008.886317110366 17396.875272128473 17777.061842287032 18160.471337362622 16176.263180376955 14909.16635741 15823.812348197895 0.8681937216843292 1.23996315256703 1.0456442478815373 1.1380877073634736 1.0994111209938437 1.1234373519546688 1.1476672585434722 1.0222734461470784 0.9421981270593076 1.0 13.949809602194302 -7.9594528398872875 5.283555855913179 0.9736820161027436 1.100960148173209 0.23417688060342734 0.09076387365982612 0.2314853956649479 15.54127364262477 0.04910303799637872 0.022164676727066325 1.0978605006622233e-08 7.9594528398872875 0.12727813207046534 STFS(ph)TNYR ddPTM_A459_Selumetinib_30min_R2 4 STFSTNYR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 STFS(0.5)T(0.5)NYR;S(0.005)T(0.005)FS(0.909)T(0.081)NYR;S(0.003)TFS(0.99)T(0.007)NYR;S(0.386)T(0.008)FS(0.579)T(0.027)NYR 125.68 0.0050277 809043000.0 431991.0 415826.0 470392.0 439022.0 427721.0 343475.0 308810.0 338776.0 295378.0 407207.0 True False 407982.6696169891 447718.51710867084 440127.4908440864 379226.44624480704 373986.8641057444 390785.56349438895 323170.2768954063 339761.78207261395 354461.8535508895 395449.8758591526 1.0316924963767098 1.1321751363202723 1.1129792110513814 0.9589747510247699 0.9457250765175289 0.9882050478467594 0.8172218443444648 0.859177870101613 0.8963509035899614 1.0 18.593135315956104 -6.070551300516914 1.3032871439420428 0.8970688225961676 1.1007413854817703 0.6156942020659896 0.05989836031113375 0.2786604587757975 0.9606585033904015 0.022719812058354997 0.03913094211183052 8.500582751383094e-07 6.070551300516914 0.20367256288560265 STFST(ph)NYR ddPTM_A459_Selumetinib_30min_R2 3 STFSTNYR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 ST(0.001)FS(0.114)T(0.885)NYR;STFS(0.068)T(0.932)NYR;STFS(0.073)T(0.927)NYR 126.31 0.011384 44623000.0 286759.0 245759.0 236102.0 276953.0 279049.0 201603.0 196566.0 223469.0 198390.0 251405.0 True False 270822.0827672294 264607.92506026564 220911.45436842067 239231.52362942693 243992.36989028825 229371.98328017857 205706.70848813956 224119.25779271568 238073.5434797475 244146.28442136364 1.1092615372340746 1.0838089372828135 0.9048323421836608 0.9798696064386772 0.9993695806944587 0.9394858653032515 0.842555146705069 0.9179712004378325 0.9751266296924862 1.0 17.897386296697825 -5.207819243321823 6.353364577648795 0.941370151354646 1.0993803308824084 0.6323154290988536 0.04621410936612242 0.1474960421015697 13.502740837867382 0.012624304449771516 0.033912076055828466 6.196989448401521e-06 5.207819243321823 0.15801017952776242 STFSTNYR ddPTM_A459_Selumetinib_30min_R1 1 STFSTNYR 8 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 143.89 0.029408 104870000.0 2400.2 2487.6 2600.2 3291.0 2460.8 2066.2 2358.5 2279.6 1409.0 1646.0 False True 2456.1199900238 2196.350635546136 2247.1071218762268 2716.288629721082 2238.2210744895283 2045.4159039594977 2180.596446160757 2219.1376028156296 2390.9700907116417 1857.2801333977295 1.3224283972340487 1.1825629295501627 1.2098913252064691 1.4625088487604034 1.2051068841160224 1.1012963888315492 1.1740805314982554 1.1948319281033357 1.2873502751238575 1.0 10.858975717912495 -6.510923520704425 24.846784719939283 1.1637773822770452 1.2870152802995038 0.31657465028970055 0.09796845639504283 764.8889230733665 1589686.748538787 0.031306840431491456 0.03364613793417331 3.083730947721826e-07 6.510923520704425 0.12323789802245866 STFVLDEFKR ddPTM_A459_Selumetinib_30min_R1 2 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 ; 133.23 0.0031209 40421000.0 6413.4 7217.4 8407.1 8689.400000000001 8018.5 7060.8 6565.700000000001 6550.200000000001 5054.8 5958.9 False True 6562.819741695963 6372.383452721771 7265.461996894708 7171.959410239558 7293.228090781155 6989.774762693454 6070.443962924602 6376.467417951803 8577.626412015054 6723.782859601294 0.9760606311556475 0.9477378412990035 1.0805616642601594 1.0666554170467129 1.0846911988489807 1.0395598591814033 0.9028316484456737 0.9483452323042321 1.2757143695927873 1.0 12.71505741904659 -5.251509120139924 24.21310660138098 1.0441843403310807 0.9618992234962638 0.1202206442576903 0.09413589784212732 1047.960902005666 2555236.7610687823 0.024328398209553938 0.06254110317390756 5.603906490940157e-06 5.251509120139924 -0.08228511683481687 STGGAPTFNVT(ph)VTK ddPTM_A459_Selumetinib_30min_R1 2 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 STGGAPT(0.001)FNVT(0.988)VT(0.011)K;STGGAPTFNVT(1)VTK 213.51 4.5281e-06 83918000.0 2582.3 4939.0 4871.200000000001 4584.4 4621.5 4114.3 4409.200000000001 4417.299999999999 1797.7199999999998 3461.1 True False 2642.4625657188813 4360.739583921194 4209.7177955862935 3783.820599846043 4203.486140992094 4072.913877485509 4076.610494132716 4300.138854587417 3050.59953972614 3905.3658989689443 0.6766235569416217 1.1166020538747656 1.0779317238104889 0.9688773594415339 1.0763360590877942 1.0429019925023668 1.043848540596153 1.1010847551372067 0.7811302752788231 1.0 11.931242007395095 -4.752651735409879 24.99241630628601 1.0292849610631396 0.676622885268358 0.5624152097921985 0.09156680388932015 239.58047645432313 681325.9135190645 0.02174573073190366 0.2531401526430655 1.7674545900344386e-05 4.752651735409879 -0.3526620757947816 STGGAPTFNVT(ph)VTK ddPTM_A459_Selumetinib_30min_R2 4 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 STGGAPTFNVT(1)VTK;STGGAPTFNVT(0.996)VT(0.004)K;STGGAPTFNVT(1)VTK;STGGAPTFNVT(1)VTK 176.08 0.00016109 40471800.0 197918.0 200669.0 198720.0 194378.0 222004.0 151195.0 155228.0 176286.0 131673.0 205903.0 True False 186918.50988852835 216059.6670474668 185934.5715499765 167903.38107924716 194113.87277905847 172020.73883844298 162446.40957844656 176798.96307428164 158011.2792510143 199958.04538975764 0.9347886429085028 1.0805250002635498 0.929867918980471 0.8396930503694932 0.9707730059107763 0.8602841586250789 0.8124024680367649 0.8841802925692018 0.7902221635694586 1.0 17.60933780414897 -5.50068781023837 6.68942953792001 0.8755469148721978 1.007816547114277 0.3492156243739589 0.0693181141309739 0.16868786143887407 30.444150761882412 0.01762991680057501 0.03489724983568022 3.157273393260745e-06 5.50068781023837 0.13226963224207922 STGGAPTFNVTVT(ph)KTDK ddPTM_A459_Selumetinib_30min_R1 2 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 STGGAPTFNVT(0.005)VT(0.992)KT(0.003)DK;STGGAPTFNVT(0.006)VT(0.977)KT(0.017)DK 135.91 0.00071335 75646000.0 3420.3 6896.2 7355.0 8634.599999999999 6164.8 6647.200000000001 5827.200000000001 5993.4 2727.7 5244.6 True False 3499.9863352547322 6088.789698043599 6356.2313981230855 7126.729201516146 5607.194928483838 6580.335203174701 5387.649612494364 5834.435562693099 4628.707676674341 5917.795496730092 0.5914341475957842 1.0288949155826677 1.0740877074301154 1.2042878476375292 0.9475141429916127 1.111957181827371 0.9104149704854345 0.985913684566651 0.7821675620984126 1.0 12.530844126352571 -7.386489233385946 17.88154375285016 0.9184072023515589 1.0063574200327403 0.043465384913717986 0.16152144626097834 7.308987225688796 1018.671002901817 0.06830142008180803 0.04604803218231213 4.106868211040917e-08 7.386489233385946 0.08795021768118139 STGGAPTFNVTVT(ph)KTDK ddPTM_A459_Selumetinib_30min_R2 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 STGGAPTFNVTVT(0.994)KT(0.006)DK 87.963 0.014314 25684000.0 78276.0 63679.0 67743.0 60274.0 75353.0 55243.0 45187.0 53768.0 43118.0 77565.0 True False 73925.73328365514 68562.97453974282 63384.48913300155 52064.5772215505 65886.48247563286 62852.22180397562 47288.285036341826 53924.45597822842 51742.804817580254 75325.49691192737 0.9814171338304096 0.9102226649750286 0.8414745568437793 0.6911946068198637 0.8746903130645011 0.8344083262731629 0.6277859021843902 0.7158858313444433 0.6869228473604276 1.0 16.20085066466104 -5.25388996901298 1.8911316394118947 0.7638998172075604 0.9769983708742103 0.2960524946126326 0.10351299369498433 0.4725018466301425 2.974852446927869 0.029244330584030503 0.12480856762158944 5.573269330073602e-06 5.25388996901298 0.21309855366664987 STGGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R1 2 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 ; 242.48 1.3569999999999998e-18 52526000.0 3997.1 3878.8999999999996 3946.0 4420.1 4399.0 3808.2 3440.1 3846.8 2885.1 3738.0 False True 4090.2246529973054 3424.756584748311 3410.15487382647 3648.212510553068 4001.1112267065305 3769.892965568945 3180.6104873595996 3744.770367832585 4895.803980633185 4217.808711203349 0.9697511037266449 0.8119753216051425 0.8085134028881898 0.8649544728907883 0.94862320713568 0.8938036842579774 0.754090738850071 0.8878473691530204 1.160745855455451 1.0 12.042277951236027 -8.176566881236253 6.412910784273876 1.078649458917539 0.8622290356978686 0.5904179840176429 0.07098758225751445 0.1468287618874129 8.974150880118499 0.04897357144702868 0.018046886178044747 6.659369592843779e-09 8.176566881236253 -0.21642042321967048 STGGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R2 2 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 ; 186.51 0.0011619999999999998 38314000.0 95030.0 81154.0 93962.0 92620.0 107503.0 72665.0 78563.0 82609.0 67762.0 89563.0 False True 89748.61303523098 87378.2508487618 87916.58721809031 80004.99622158826 93997.51205098606 82673.94416280594 82216.33516963126 82849.37851334379 81316.2934284724 86977.08347737981 1.0318650551046813 1.0046123341384092 1.0108017388391142 0.9198399512027235 1.0807158425291652 0.9505255965993273 0.9452643372551497 0.9525426146864362 0.9349163041276314 1.0 16.40834771259533 STGHGGHCTNCQDNTDGAHCER ddPTM_A459_Selumetinib_30min_R1 1 STGHGGHCTNCQDNTDGAHCER 22 0 P11047 P11047 LAMC1 Laminin subunit gamma-1 0 81.878 0.00034712 525380.0 249.39 251.35 272.05 294.28 322.88 138.06 245.78 196.37 0.0 59.524 False True 255.20030177153401 221.9218251505552 235.10710426368246 242.88952231975688 293.67556100909394 136.6712417484504 227.24061672138683 191.1616297003444 0.0 67.16448521285933 3.79963162023422 3.304154337627023 3.500467598591358 3.6163386282197423 4.3724828691587545 2.0348736585311205 3.3833448734284244 2.8461712926781213 0.0 1.0 6.069626670878303 -8.158147524688586 4.243107378782899 0.5128720554600363 3.399877075493831 0.7853299660085789 0.6021266060240941 0.09803589005537203 2.9088750332729645 0.455219976506269 0.1562241213371692 6.947882661592004e-09 8.158147524688586 2.8870050200337944 STGHGGHCTNCQDNTDGAHCER ddPTM_A459_Selumetinib_30min_R2 1 STGHGGHCTNCQDNTDGAHCER 22 0 P11047 P11047 LAMC1 Laminin subunit gamma-1 0 124.73 1.1289000000000003e-05 1506800.0 977.26 638.63 3024.5 3009.5 4805.5 3171.9 896.29 2393.0 2865.2 3921.2 False True 922.9478014817414 687.6108674808959 2829.9069628266147 2599.6009083229283 4201.790128284925 3608.8004333586223 937.9692609649422 2399.963233817525 3438.320060376896 3807.98476749887 0.24237171570619084 0.18057080305300877 0.7431508095777735 0.6826710365310567 1.103415686992023 0.9476929803290484 0.2463164424843568 0.6302449669182499 0.9029237957365113 1.0 11.89481199232638 -5.265647029975773 19.20846847471505 0.7635572064579882 0.21147059116189276 0.49963668813332707 0.22779746557047234 11.856177898112245 54139.060272036404 0.0632018949505364 0.14096789785489633 5.424415771693939e-06 5.265647029975773 -0.5520866152960955 STGHT(ph)PTKPSGSSVSEK ddPTM_A459_Selumetinib_30min_R2 1 STGHTPTKPSGSSVSEK 17 1 Q8NI08-2;Q8NI08;Q8NI08-7 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 S(0.183)T(0.183)GHT(0.622)PT(0.011)KPSGSSVSEK 74.14699999999998 0.032561 7824800.0 23896.0 20860.0 25586.0 30891.0 34453.0 23858.0 25489.0 28406.0 19064.0 27991.0 True False 22567.955983267195 22459.894924528264 23939.824615930487 26683.592510052702 30124.706126272064 27144.222938639312 26674.28900549531 28488.656757133547 22877.332692665485 27182.82710064797 0.8302284342870735 0.8262530913862479 0.8806966445134702 0.9816341917363199 1.1082256460938151 0.9985798327059315 0.9812919350415712 1.0480387728491438 0.8416097636923183 1.0 14.730407888339874 -5.67776497710805 3.0568829229013903 1.0017703432223237 0.8321790525679169 0.5465927098973995 0.06305697862374106 0.18237694708205232 3.406115930932357 0.017957395351433834 0.03342892534846489 2.1000760537638156e-06 5.67776497710805 -0.1695912906544068 STGS(ph)PTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R1 2 STGSPTQETQAPFIAK 16 0 O15231-3;O15231-2;H0Y704 O15231-3 ZNF185 Zinc finger protein 185 1 S(0.001)T(0.004)GS(0.99)PT(0.005)QETQAPFIAK;S(0.004)T(0.002)GS(0.994)PT(0.001)QETQAPFIAK 265.43 7.8553e-40 35660000.0 6560.5 6585.9 7228.5 7539.6 7003.2 6172.5 6567.8 6063.6 3405.9 5198.6 True False 6713.346885489188 5814.819766298156 6246.909403308321 6222.950395820437 6369.761796515386 6110.410254181586 6072.385558233887 5902.773630651364 5779.563542906163 5865.89094865215 1.1444718192437187 0.9912935336164528 1.0649549161400147 1.0608704543425465 1.0858984342317197 1.0416849388558138 1.0352025994668697 1.006287652178002 0.9852831553634963 1.0 12.518134535214651 -7.5663262496210635 1.4841646603304217 0.9920981596944253 1.063755779267876 0.4275816058397022 0.035633830176084694 0.4166880743642095 1.7568483601276028 0.02431161369085545 0.011100223648081596 2.7143993983736017e-08 7.5663262496210635 0.07165761957345074 STGS(ph)PTQETQAPFIAK ddPTM_A459_Selumetinib_30min_R2 3 STGSPTQETQAPFIAK 16 0 O15231-3;O15231-2;H0Y704 O15231-3 ZNF185 Zinc finger protein 185 1 S(0.014)TGS(0.985)PTQETQAPFIAK;STGS(1)PTQETQAPFIAK;S(0.001)T(0.002)GS(0.993)PT(0.005)QETQAPFIAK 270.95 1.5859e-50 33517000.0 126877.0 125812.0 140656.0 142860.0 143177.0 100436.0 116271.0 102276.0 103239.0 125904.0 True False 119825.68426887314 135461.37585065892 131606.34609467353 123402.22155275437 125189.82524137983 114270.14733276803 121677.83188661568 102573.6062272967 123889.6847386747 122268.82438212191 0.9800182906346321 1.1078979170299934 1.0763687862358882 1.0092697151245218 1.023889988915973 0.934581222238991 0.9951664498412185 0.8389187247497161 1.01325653014776 1.0 16.89969707255527 -6.4968490355932005 1.5406087082295317 0.9468448161317581 1.05572143405773 0.3361753705507948 0.05698238459931466 0.3827869099309207 1.8482690372662873 0.021806123975658957 0.02454646315209032 3.185304567906718e-07 6.4968490355932005 0.10887661792597181 STGSPT(ph)QETQAPFIAK ddPTM_A459_Selumetinib_30min_R1 1 STGSPTQETQAPFIAK 16 0 O15231-3;O15231-2;H0Y704 O15231-3 ZNF185 Zinc finger protein 185 1 S(0.003)T(0.001)GS(0.441)PT(0.512)QET(0.044)QAPFIAK 182.15 2.1801e-06 6900100.0 1509.5 1608.3 1469.0 1794.5 1515.7 1289.5 1171.9 1331.2 848.06 1375.8 True False 1544.6684130243016 1419.9994883216152 1269.5178686394038 1481.1242619369439 1378.605202618569 1276.528800772322 1083.5026394978968 1295.8922516529938 1439.0958801482716 1552.3973314268505 0.9950213014116398 0.9147139456987182 0.8177789557732333 0.9540883844315826 0.8880491963687257 0.8222951527487037 0.6979544589283854 0.8347684097484914 0.9270151726076207 1.0 10.600282142905456 -6.608675816036622 4.834309986953495 0.8366629933567896 0.9136142451485474 0.08793412805966083 0.08473355031869215 0.42043770637831235 17.288526338842555 0.02886259636359253 0.02890395978774519 2.462204858641293e-07 6.608675816036622 0.07695125179175777 STGTEPPGEVRLADS(ph)AASR ddPTM_A459_Selumetinib_30min_R2 1 STGTEPPGEVRLADSAASR 19 1 O43586-2 O43586-2 1 STGTEPPGEVRLADS(1)AASR 96.773 0.0076185 33860000.0 14938.0 14892.0 17731.0 16151.0 16525.0 14655.0 12027.0 13883.0 11927.0 12940.0 True False 14107.80576155194 16034.168514672818 16590.206764053124 13951.205937970974 14448.981764625601 16673.593225155462 12586.279331048385 13923.397231545625 14312.733268223948 12566.388577842328 1.1226619067332928 1.2759567647736956 1.320204819490127 1.110200106542179 1.1498117915995971 1.326840493740195 1.0015828535846114 1.1079871631612634 1.1389694962529537 1.0 13.617282476449002 -7.794743987069847 0.4726825906266272 1.00957306303323 1.233942506204555 0.3332465199962197 0.09113194633620877 1.093805877619011 0.5977662556907165 0.09845029590649923 0.07022672410240799 1.604190768929855e-08 7.794743987069847 0.224369443171325 STIFIS(ph)PSSVK ddPTM_A459_Selumetinib_30min_R1 1 STIFISPSSVK 11 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 STIFIS(0.985)PS(0.006)S(0.009)VK 143.55 0.00083027 14141000.0 2156.3 2787.2 3076.4 3555.9 2598.8 2116.3 2372.7 2146.5 1360.3 2116.9 True False 2206.5375945705864 2460.873328265875 2658.6417774555894 2934.9288175099346 2363.7389988554055 2095.011943446659 2193.7253287282692 2089.56784718536 2308.329747618911 2388.624735352158 0.9237690466456941 1.030246941616413 1.1130428895368625 1.228710719633921 0.9895815629268012 0.8770787275372449 0.918405179457729 0.8747995514989474 0.9663844275976615 1.0 11.221964501800016 -6.518332967282602 23.696343106528353 0.9205482156800225 1.078055682875421 0.43203317517107775 0.07900111406513292 92.95435211979142 484560.9655457722 0.0269846395770454 0.027711361631934127 3.0315660352534903e-07 6.518332967282602 0.15750746719539854 STIFIS(ph)PSSVK ddPTM_A459_Selumetinib_30min_R2 1 STIFISPSSVK 11 0 E9PHV5;P28290-3;P28290;P28290-2;E7EUL7 E9PHV5 SSFA2 Sperm-specific antigen 2 1 S(0.081)T(0.055)IFIS(0.419)PS(0.419)S(0.026)VK 99.732 0.016965 11245000.0 45595.0 42699.0 36874.0 45091.0 45923.0 29051.0 31410.0 35243.0 26218.0 32831.0 True False 43061.01243124654 45973.876001075376 34501.56698537561 38949.528013686366 40153.742183171074 33052.511551278825 32870.62723773424 35345.55129520728 31462.332592126713 31883.083724817727 1.3505912038780596 1.4419519892703918 1.0821276662934478 1.221636161353117 1.2594058507557562 1.0366786298513158 1.0309739020679425 1.1085988921358438 0.9868033112379433 1.0 14.960503552772062 -3.5419145341914184 0.27325813179346675 0.9821821991592122 2.1674800174690874 0.6843530936473359 0.08427402332901801 10.082958052749273 0.3651906683339709 0.10267610693977773 4.518727075242665 0.0002871345585121343 3.5419145341914184 1.1852978183098752 STIGVMVT(ph)ASHNPEEDNGVK ddPTM_A459_Selumetinib_30min_R1 1 STIGVMVTASHNPEEDNGVK 20 0 D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RC77 PGM3 Phosphoacetylglucosamine mutase 1 STIGVMVT(0.885)AS(0.115)HNPEEDNGVK 155.31 2.5266e-06 95489000.0 6611.8 8546.2 7685.2 9336.0 7014.6 7939.3 7650.9 6806.8 3697.4 6454.2 True False 6765.842075676765 7545.606930979408 6641.5920517818495 7705.642858424804 6380.130668528215 7859.43785030764 7073.78645322507 6626.2615523975355 6274.217752588519 7282.659439231848 0.9290345281325422 1.0361059711691385 0.9119734496993565 1.0580809006273635 0.8760715397672325 1.079198871770479 0.9713191331065716 0.9098683808694551 0.8615283750314024 1.0 12.830249666289799 -7.714713756900258 5.660784290998878 0.9141507957356344 0.9830600064810131 0.11972830827111702 0.0687904828471585 0.31900872589096074 23.334765991385083 0.03148406517972727 0.0173759791279212 1.9287957618773317e-08 7.714713756900258 0.0689092107453787 STIGVMVT(ph)ASHNPEEDNGVK ddPTM_A459_Selumetinib_30min_R2 2 STIGVMVTASHNPEEDNGVK 20 0 D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RC77 PGM3 Phosphoacetylglucosamine mutase 1 STIGVMVT(0.547)AS(0.453)HNPEEDNGVK;STIGVMVT(0.79)AS(0.21)HNPEEDNGVK 109.84 0.0005286000000000001 259413000.0 277940.0 267630.0 282280.0 296890.0 295190.0 169474.0 200677.0 248400.0 173283.0 238568.0 True False 262493.2074819754 288156.3604339163 264118.41212322545 256453.0698361832 258105.59316791725 192817.50516820166 210008.87813393187 249122.8028751662 207944.44193155435 231679.9219658961 1.1329993779979566 1.2437692398581424 1.1400142484600129 1.106928333107492 1.114061119227721 0.8322581582904061 0.9064612779213804 1.0752887033164564 0.8975505523614788 1.0 17.821773496044145 -6.617343458504088 6.444701323642896 0.9453561955866535 1.154982433721959 0.6914866663543329 0.06893299178260502 0.12963570044909556 7.426642590578274 0.023806908713615058 0.023780180359486872 2.4135513406791215e-07 6.617343458504088 0.20962623813530545 STIGVMVTAS(ph)HNPEEDNGVK ddPTM_A459_Selumetinib_30min_R1 11 STIGVMVTASHNPEEDNGVK 20 0 D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RC77 PGM3 Phosphoacetylglucosamine mutase 1 STIGVMVT(0.015)AS(0.985)HNPEEDNGVK;STIGVMVTAS(1)HNPEEDNGVK;STIGVMVT(0.087)AS(0.913)HNPEEDNGVK;STIGVMVT(0.022)AS(0.978)HNPEEDNGVK;STIGVMVTAS(1)HNPEEDNGVK;STIGVMVTAS(1)HNPEEDNGVK;STIGVMVT(0.002)AS(0.998)HNPEEDNGVK;STIGVMVT(0.007)AS(0.993)HNPEEDNGVK;STIGVMVT(0.312)AS(0.688)HNPEEDNGVK;STIGVMVT(0.082)AS(0.918)HNPEEDNGVK;STIGVMVT(0.08)AS(0.92)HNPEEDNGVK 174.25 2.8956e-10 649122000.0 50972.4 63253.799999999996 61344.09999999999 69400.3 56056.8 56055.9 55550.5 50826.7 30214.89 46807.899999999994 True False 52159.9577449751 55848.015690106164 53013.908159021375 57280.84040997629 50986.47233763186 55492.02854068492 51360.28106103587 49478.61080761063 51272.46152174753 52816.14991255621 0.9875759181866244 1.0574041421529132 1.003744276074507 1.084532676175979 0.965357611678367 1.0506640228899486 0.9724351575430865 0.9368083605020189 0.9707724172745561 1.0 15.688691518151998 -7.367641540804286 6.027777145429028 0.9635443176139706 1.0252796208102994 0.3574653347694672 0.035756121563811236 0.2318893692715677 11.191554680966334 0.014198898765214811 0.009478716426126648 4.289023829913147e-08 7.367641540804286 0.061735303196328806 STIGVMVTAS(ph)HNPEEDNGVK ddPTM_A459_Selumetinib_30min_R2 13 STIGVMVTASHNPEEDNGVK 20 0 D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RC77 PGM3 Phosphoacetylglucosamine mutase 1 STIGVMVT(0.045)AS(0.955)HNPEEDNGVK;STIGVMVT(0.006)AS(0.994)HNPEEDNGVK;STIGVMVT(0.005)AS(0.995)HNPEEDNGVK;STIGVMVT(0.031)AS(0.969)HNPEEDNGVK;STIGVMVT(0.008)AS(0.992)HNPEEDNGVK;S(0.002)T(0.002)IGVMVT(0.062)AS(0.934)HNPEEDNGVK;STIGVMVT(0.012)AS(0.988)HNPEEDNGVK;STIGVMVT(0.033)AS(0.967)HNPEEDNGVK;STIGVMVT(0.01)AS(0.99)HNPEEDNGVK;STIGVMVT(0.105)AS(0.895)HNPEEDNGVK;STIGVMVT(0.333)AS(0.667)HNPEEDNGVK;STIGVMVT(0.044)AS(0.956)HNPEEDNGVK;STIGVMVT(0.059)AS(0.941)HNPEEDNGVK 153.93 3.3029e-06 519218700.0 923083.0 823150.0 972328.0 956634.0 1004734.0 644190.0 662321.0 722673.0 600235.0 832309.0 True False 871781.7422540269 886282.9581555817 909769.4750706793 826338.7989143045 878510.3324840756 732921.3251254113 693120.2388641646 724775.8587850448 720298.7719671667 808278.0765715137 1.078566606621174 1.096507481577309 1.1255649527569316 1.0223446891191201 1.0868912048319648 0.9067687796683236 0.8575269563219926 0.89669122520227 0.8911521824549167 1.0 19.624492191513774 -6.767890389430024 8.812284204800399 0.9004418447461717 1.0820112787834906 0.8059690599390725 0.041943572871726946 0.050319787441447196 36.28838920343515 0.014049695858020054 0.01299028451798329 1.7065130374955613e-07 6.767890389430024 0.18156943403731884 STLESEKPGS(ph)PEAAET(ph)SPPSNIIDHCEK ddPTM_A459_Selumetinib_30min_R2 1 STLESEKPGSPEAAETSPPSNIIDHCEK 28 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 2 S(0.062)T(0.062)LES(0.139)EKPGS(0.698)PEAAET(0.516)S(0.516)PPS(0.007)NIIDHCEK 51.58600000000001 0.03058 17286000.0 53555.0 46511.0 52385.0 49250.0 49266.0 41463.0 44639.0 42460.0 34706.0 47620.0 True False 50578.627497651236 50078.2441435635 49014.60613247547 42542.065039011184 43076.764636371874 47174.15188636104 46714.801950500434 42583.55157036859 41648.16976666223 46245.08686838111 1.093708130370776 1.0828878813892597 1.0598878594817376 0.9199261569145895 0.9314884575516822 1.0200900264416013 1.0101570807609506 0.9208232582969585 0.9005966381941881 1.0 15.497012479726829 -5.650476596639814 5.358560490766519 0.9582574303091878 1.084009976201093 0.6697077007479459 0.03924703387364427 0.1315304311245286 5.64240682951706 0.01171423960948184 0.020586444170900303 2.2362657038723544e-06 5.650476596639814 0.12575254589190532 STLESEKPGS(ph)PEAAETSPPSNIIDHCEK ddPTM_A459_Selumetinib_30min_R1 1 STLESEKPGSPEAAETSPPSNIIDHCEK 28 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 STLES(0.001)EKPGS(0.997)PEAAET(0.001)SPPSNIIDHCEK 123.03 2.1259e-12 24842000.0 2563.3 3067.8 3087.4 3750.9 2598.0 3291.9 2864.9 2942.8 1549.7 2514.6 True False 2623.019902686447 2708.6205498184713 2668.1480378742644 3095.8757281132807 2363.011358714153 3258.7864748060547 2648.7982864557785 2864.747384438424 2629.727714390229 2837.373404278206 0.9244535452159537 0.9546225201569872 0.9403584434291297 1.0911062052831337 0.8328164897687391 1.148522245923797 0.933538843517003 1.009647648109672 0.926817637194002 1.0 11.470340309455281 -5.614097845150075 23.091695382051878 0.9916668653215676 0.9412181247880406 0.07672240810858355 0.08256183665160548 27.198754203529276 6867.932453151749 0.02085367926335795 0.0361196461908206 2.4316561030556243e-06 5.614097845150075 -0.05044874053352699 STLESEKPGS(ph)PEAAETSPPSNIIDHCEK ddPTM_A459_Selumetinib_30min_R2 3 STLESEKPGSPEAAETSPPSNIIDHCEK 28 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 1 S(0.006)T(0.006)LES(0.035)EKPGS(0.899)PEAAET(0.047)S(0.007)PPSNIIDHCEK;STLES(0.004)EKPGS(0.975)PEAAET(0.019)S(0.002)PPSNIIDHCEK;S(0.007)T(0.007)LES(0.071)EKPGS(0.723)PEAAET(0.083)S(0.104)PPS(0.003)NIIDHCEK 96.41 6.7961e-07 74676000.0 178673.0 150530.0 149708.0 162336.0 182686.0 130979.0 151177.0 156401.0 112410.0 168617.0 True False 168743.0699446892 162075.16696976207 140075.9502697459 140225.55675478003 159735.3514464384 149020.16834101928 158207.03005154253 156856.10101642058 134895.1409978245 163748.58909042008 1.030500909241491 0.9897805402174551 0.8554330211199412 0.8563466563815649 0.9754914673385943 0.9100546708144891 0.9661581264934286 0.9579081071031791 0.8237942186075078 1.0 17.32112295042416 -5.0528482815299 6.475764309682522 0.9179351401065866 1.0213093492988075 0.3173971663443568 0.05540075190138884 0.21901473587623602 21.424449279079173 0.0140155290952904 0.03945703757047179 8.854248742838297e-06 5.0528482815299 0.10337420919222085 STLESEKPGSPEAAET(ph)S(ph)PPSNIIDHCEK ddPTM_A459_Selumetinib_30min_R1 1 STLESEKPGSPEAAETSPPSNIIDHCEK 28 1 Q96T23-3;Q96T23-2;Q96T23;H0YCN2;H0YER1 Q96T23-3 RSF1 Remodeling and spacing factor 1 2 S(0.011)T(0.017)LES(0.029)EKPGS(0.055)PEAAET(0.933)S(0.933)PPS(0.022)NIIDHCEK 51.052 0.034452 11943000.0 1443.3 2344.0 2236.2 2408.8 1972.2 1902.1 2078.6 1680.2 1122.0 2101.5 True False 1476.9260818270782 2069.5633903039648 1932.536322567348 1988.1482987760987 1793.8148582201895 1882.9666009686198 1921.8095285095383 1635.6356379412264 1903.9520523622882 2371.247995343454 0.6228475826768843 0.8727739124579448 0.8149870137422878 0.8384396329191764 0.7564855560206268 0.7940825272878677 0.8104633223869869 0.6897783956605177 0.8029324879140353 1.0 11.211430838642842 -11.914700021288658 1.9075567668538231 2.2191591864421616 0.781922948943848 0.47731825190786425 0.06956127851535157 4273327.189088403 399403.83528381336 22444306.062968638 0.01674464994971559 1.2170263427467026e-12 11.914700021288658 -1.4372362374983136 STLINSLFLTDLYSPEYPGPS(ph)HR ddPTM_A459_Selumetinib_30min_R1 1 STLINSLFLTDLYSPEYPGPSHR 23 0 E7EPK1;G3V1Q4;Q16181;Q16181-2;E7ES33;A0A0U1RRE1;A0A5F9ZGZ7;A0A0U1RRH9 E7EPK1 SEPT7 Septin-7 1 STLINSLFLT(0.035)DLY(0.051)S(0.063)PEY(0.004)PGPS(0.846)HR 55.819 0.012338 1517600.0 303.08 504.17 425.77 592.74 449.22 475.48 462.09 398.35 249.0 307.51 True False 310.14117430898 445.14154201772567 367.9527725872011 489.22908610783145 408.58813031623265 470.69710290129797 427.2341792692067 387.78446397684047 422.5348137595452 346.9819039010543 0.8938252134250211 1.2828955545320389 1.0604379319220256 1.409955621914336 1.177548816588274 1.3565465449619598 1.231286630414701 1.1175927609395488 1.2177430840313668 1.0 8.438716613866509 -4.754129478572641 24.987258195324976 1.2161059143390867 0.8938246438559674 0.3758567112633935 0.12005043916134724 257.8604180977296 881363.265772396 0.028049378759061324 0.28177575386118786 1.76145081722183e-05 4.754129478572641 -0.3222812704831193 STLNPQWNES(ph)FTFK ddPTM_A459_Selumetinib_30min_R1 2 STLNPQWNESFTFK 14 0 P17252;J3KRN5 P17252 PRKCA Protein kinase C alpha type 1 STLNPQWNES(0.973)FT(0.027)FK;STLNPQWNES(0.976)FT(0.024)FK 205.33 1.3341e-05 192139000.0 11027.9 11792.400000000001 13462.7 14837.8 11918.2 10849.0 11253.0 11099.3 6774.5 9334.0 True False 11284.828613442 10411.740325861976 11634.539285317702 12246.656770001664 10840.200914329107 10739.86891010386 10404.177150157722 10804.910508392482 11495.831710096538 10532.109820859301 1.0714689464300786 0.988571188769896 1.104673183551029 1.162792353887787 1.029252552310043 1.0197262554966036 0.9878530823474512 1.0259018081061866 1.0915032130911266 1.0 13.362506849455013 -6.482643628747551 24.9864868446635 1.0243158722619699 1.0792379001132981 0.2525385797085403 0.04729442336186838 821.264930755341 510015.9175209452 0.015689658639851608 0.017788270059406548 3.291215890922294e-07 6.482643628747551 0.05492202785132827 STLNPQWNES(ph)FTFK ddPTM_A459_Selumetinib_30min_R2 2 STLNPQWNESFTFK 14 0 P17252;J3KRN5 P17252 PRKCA Protein kinase C alpha type 1 STLNPQWNES(0.999)FT(0.001)FK;STLNPQWNES(0.98)FT(0.02)FK 258.14 1.1467999999999999e-35 39656000.0 131041.0 95325.0 108872.0 125894.0 105962.0 86860.0 84695.0 93768.0 63555.0 97526.0 True False 123758.26581868585 102636.12098181498 101867.29405087087 108747.02002073643 92650.10624770088 98824.17656342556 88633.48531995875 94040.84935587205 76267.77587507114 94710.17097702075 1.3067051251413424 1.083686365709521 1.0755686849682347 1.1482084648239246 0.978248748702822 1.043437843517387 0.9358391438387713 0.992932948866589 0.8052754533995695 1.0 16.53123174537169 -1.5228787452803587 0.29273370317348085 0.9191508482675735 3.7513438842737803 0.6728923962714568 0.07223341743019697 31.489587464451315 0.44747107338953723 0.073978514807797 46.31178101009458 0.029999999999998538 1.5228787452803587 2.8321930360062066 STLPDADRER ddPTM_A459_Selumetinib_30min_R1 3 STLPDADRER 10 1 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ;; 150.81 0.001961 134503000.0 10296.2 11025.400000000001 13686.899999999998 15441.3 13557.600000000002 11233.4 11140.100000000002 10677.4 6629.6 8738.9 False True 10536.081427082348 9734.541042430596 11828.294156760137 12744.766824099705 12331.317473788698 11120.402195111134 10299.793288054043 10394.200666916822 11249.946993173815 9860.622939094417 1.0685005898876774 0.9872135972095694 1.1995483682744315 1.29249104268763 1.2505617089259866 1.1277585872411842 1.044537789516162 1.0541119695092416 1.1408961748827393 1.0 13.267463075560803 -7.079871249435102 5.239972983191377 1.0656993685604024 1.1622970544405324 0.22387455196628925 0.08731319176764935 0.41521592796268564 19.76834757714987 0.03840008691486272 0.029851171913114725 8.320103916224695e-08 7.079871249435102 0.09659768588013007 STLPDADRER ddPTM_A459_Selumetinib_30min_R2 1 STLPDADRER 10 1 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 106.18 0.033983 58269000.0 38699.0 35423.0 43421.0 46778.0 45669.0 30062.0 29754.0 29904.0 25448.0 37241.0 False True 36548.264504371284 38139.83019710281 40627.34013321026 40406.75570344906 39931.651933959845 34202.76762433461 31137.619956432496 29991.015689126303 30538.311076529142 36165.75556626169 1.0105765504444881 1.054584083753602 1.1233648930346334 1.1172656307267563 1.1041287900317307 0.9457224683629086 0.8609697065331096 0.8292655640548631 0.8443985366371752 1.0 15.14233667196349 -6.921221286496525 3.3961255917677566 0.8715686676678791 1.0847520731233282 0.7531688849633331 0.053816935122593806 0.11346010382683952 2.6198364278856308 0.02067404940262584 0.017734500173178284 1.198888276765782e-07 6.921221286496525 0.21318340545544912 STLS(ph)PPEASPGPPAAPR ddPTM_A459_Selumetinib_30min_R2 1 STLSPPEASPGPPAAPR 17 0 Q6NUJ5-2;Q6NUJ5 Q6NUJ5-2 PWWP2B PWWP domain-containing protein 2B 1 S(0.088)T(0.287)LS(0.625)PPEAS(0.001)PGPPAAPR 144.15 0.00032671 0.0 21902.0 17316.0 21316.0 22607.0 20563.0 15466.0 22514.0 19981.0 17566.0 19955.0 True False 20684.774520652736 18644.081520284344 19944.551767106008 19527.887600749775 17979.692104447593 17596.301113630456 23560.945610644656 20039.14140196739 21079.69083504837 19378.847300683454 1.067389313704083 0.9620841338497365 1.0291918532431288 1.007690875404187 0.9277998750634402 0.9080158814714366 1.2158073824036844 1.0340729296762996 1.0877680446093887 1.0 14.242195137967768 -7.241773231313145 24.992268940178832 1.0872515273313255 0.9833310301700527 0.3460822609525047 0.06777728767563228 906.4703081917362 1151968.7206959683 0.025602449298289726 0.019801217920682318 5.730951969365363e-08 7.241773231313145 -0.10392049716127272 STLSPPEAS(ph)PGPPAAPR ddPTM_A459_Selumetinib_30min_R2 1 STLSPPEASPGPPAAPR 17 0 Q6NUJ5-2;Q6NUJ5 Q6NUJ5-2 PWWP2B PWWP domain-containing protein 2B 1 STLS(0.083)PPEAS(0.916)PGPPAAPR 82.94200000000002 0.035578 0.0 8963.4 7274.6 8670.4 9216.4 9679.7 7525.3 7578.7 9167.5 7348.1 7523.5 True False 8465.250111333156 7832.538428474275 8112.555903617741 7961.1104208232055 8463.649548384052 8561.841767128104 7931.124566909157 9194.175907238676 8817.925323068359 7306.2770065994455 1.158627041335397 1.072028670881145 1.1103542743164567 1.089626141143058 1.158407974504553 1.171847407290274 1.0855220189085786 1.258394103992221 1.2068972084008731 1.0 12.83492073703043 -6.272888975299881 22.571261234340398 1.1579484954523895 1.10530652572012 0.05844713425631998 0.06862496473883302 439.50022124855406 866409.7369872887 0.02063743835957065 0.023656108577292702 5.334712566865548e-07 6.272888975299881 -0.05264196973226953 STLTDS(ph)LVCK ddPTM_A459_Selumetinib_30min_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 1 S(0.001)TLT(0.258)DS(0.741)LVCK 84.68700000000003 0.03752 4677000.0 1053.2 1442.9 1581.5 2065.6 1812.1 1643.6 1723.8 1667.9 665.99 1299.6 True False 1077.7375108295423 1273.9645972139886 1366.7409865576699 1704.8817361142112 1648.1958749522396 1627.066876269398 1593.7723781606574 1623.661873897258 1130.136388014938 1466.4163191759953 0.7349464792066291 0.8687605153834153 0.9320279436917787 1.1626178144772787 1.1239617654271532 1.109553170537324 1.086848500878813 1.1072311816671692 0.7706790856296396 1.0 10.51807903093299 -5.251801025176534 1.9568727624672648 1.0613069765456982 0.7556909716860741 0.4647328708333547 0.10764284102941576 0.3320038752159787 2.2616955474654192 0.030677540991368702 0.12733698353017514 5.600141168151979e-06 5.251801025176534 -0.30561600485962404 STLTDS(ph)LVCK ddPTM_A459_Selumetinib_30min_R2 2 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 1 STLTDS(1)LVCK;STLT(0.022)DS(0.978)LVCK 114.82 0.0068408 2258400.0 36241.0 36247.0 42017.0 42705.0 45647.0 26307.0 38148.0 34415.0 28541.0 39052.0 True False 34226.8703042177 39027.02834752523 39313.67196465061 36888.50532976596 39912.41577064237 29930.550458830756 39921.95758882796 34515.14195229004 34249.997502169834 37924.467290718625 0.9025010171360838 1.0290725522485173 1.0366308289390782 0.9726835461389276 1.0524186263365198 0.7892147892122339 1.0526702269222958 0.9101022220749041 0.9031108397546811 1.0 15.210841295224498 STLTTLPFPGAEANS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 STLTTLPFPGAEANSPGK 18 0 Q96GV9 Q96GV9 C5orf30 UNC119-binding protein C5orf30 1 STLTTLPFPGAEANS(1)PGK 120.08 0.00096126 3553000.0 25589.0 22069.0 21396.0 28747.0 21432.0 19063.0 26259.0 24781.0 21283.0 18230.0 True False 24166.865820883155 23761.62133698057 20019.4046542034 24831.60900865899 18739.520555489013 21688.755213315486 27480.095531221392 24853.108607284616 25540.194696705817 17703.652532771684 1.3650779564356705 1.3421875114750939 1.130806460256999 1.4026263203422324 1.0585115427903822 1.2251005928390695 1.552227455907886 1.4038407363270595 1.4426511506271211 1.0 14.111759420495629 STLTTLPFPGAEANS(ph)PGKAEAEKPR ddPTM_A459_Selumetinib_30min_R1 2 STLTTLPFPGAEANSPGKAEAEKPR 25 2 Q96GV9 Q96GV9 C5orf30 UNC119-binding protein C5orf30 1 STLTTLPFPGAEANS(1)PGKAEAEKPR;STLTTLPFPGAEANS(1)PGKAEAEKPR 108.69 9.3172e-08 120231000.0 8842.8 9598.9 11797.2 12696.6 8270.9 9839.6 8588.3 9034.3 5554.8 8078.9 True False 9048.820034906454 8475.056325592457 10195.205037381049 10479.377154699694 7522.798555345998 9740.62255764199 7940.477616519996 8794.681016457822 9426.08989345992 9115.905510150013 0.9926408325350824 0.9296998873184887 1.1183974017753147 1.1495706206071945 0.8252387595472347 1.06853044349751 0.8710574728619941 0.9647621957758857 1.0340267220809316 1.0 13.154170255256467 -6.2489243610364635 24.99501238108529 0.9597598380148042 1.0442159505442339 0.18971198445655035 0.08793825600490952 1419.436684209157 2834900.4328393117 0.02630842240070598 0.033716010489199345 5.637358304118118e-07 6.2489243610364635 0.08445611252942964 STLTTLPFPGAEANS(ph)PGKAEAEKPR ddPTM_A459_Selumetinib_30min_R2 2 STLTTLPFPGAEANSPGKAEAEKPR 25 2 Q96GV9 Q96GV9 C5orf30 UNC119-binding protein C5orf30 1 STLTTLPFPGAEANS(1)PGKAEAEKPR;STLTTLPFPGAEANS(1)PGKAEAEKPR 93.851 5.4261e-06 24066000.0 209259.0 196135.0 197733.0 197247.0 170570.0 151138.0 173960.0 168312.0 115291.0 183052.0 True False 197629.22251014848 211177.92382657438 185011.07405541226 170381.61832994578 149141.47168485276 171955.88760583737 182049.48469520055 168801.7600544482 138352.42149969013 177766.8131337864 1.1117329439967725 1.1879490896179983 1.0407514810774825 0.9584557169381072 0.8389725227993464 0.967311527807073 1.0240915134040853 0.9495684660072568 0.7782803722512975 1.0 17.43962649041442 -5.574554819625076 2.623669703328524 0.9292929238503995 1.1490039826947296 0.6045551846775055 0.0712665887960881 0.1869887239105688 2.5827294088866912 0.020795895719644623 0.04440065393890674 2.663453876150488e-06 5.574554819625076 0.21971105884433006 STNGDTFLGGEDFDQALLR ddPTM_A459_Selumetinib_30min_R2 1 STNGDTFLGGEDFDQALLR 19 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 116.87 0.0064208 2198500.0 7305.7 5540.7 4335.0 5695.2 6092.1 3716.5 6510.2 4818.5 4670.5 4521.8 False True 6899.678441034276 5965.653873841502 4056.0908195911297 4919.503935232014 5326.755933934987 4228.414139972043 6812.937199716568 4832.521037254382 5604.730504673427 4391.2438849526625 1.5712355363994215 1.3585339439432687 0.9236769639440908 1.1202984994956722 1.2130403305969897 0.9629194485101173 1.5514823084780707 1.1004902400920682 1.2763423420591558 1.0 12.100413947079364 -4.999186747002626 5.258330624206376 1.155242360412143 1.5329406382694448 0.3841314986699319 0.17205942658333714 0.16155270106557196 14.752969278387729 0.04275801444453411 0.1540257293132694 1.0018743386093373e-05 4.999186747002626 0.3776982778573019 STNPVT(ph)FMSNMLYACS(ph)ILY(ph)KTK ddPTM_A459_Selumetinib_30min_R2 1 STNPVTFMSNMLYACSILYKTK 22 1 Q9HCN4-3;Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5 Q9HCN4-3 GPN1 GPN-loop GTPase 1 3 S(0.11)T(0.069)NPVT(0.299)FMS(0.523)NMLY(0.313)ACS(0.698)ILY(0.681)KT(0.307)K 50.938 0.033858 4272600.0 7189.8 6759.0 7820.9 8933.8 8354.9 5385.1 8227.8 7100.7 6497.6 7548.4 True False 6790.21969904982 7277.393566389577 7317.711808752075 7717.001028335394 7305.282768246318 6126.848643929355 8610.409003076396 7121.361861415832 7797.301558112847 7330.458078901475 0.9263022345893267 0.9927610918798337 0.9982611904996651 1.0527310770041052 0.996565656554586 0.8358070638946358 1.174607222413409 0.9714756956202418 1.0636854442364305 1.0 12.839687639571011 -7.268245955702904 24.999859163469562 1.050065049448103 0.9748910890680968 0.24230513924058505 0.07312911046151617 929.7717518143294 3414936.983925902 0.02980869342475337 0.020609210111008174 5.392051658446844e-08 7.268245955702904 -0.07517396038000612 STNSPT(ph)IVSPAIVSPTQDSRPNMSR ddPTM_A459_Selumetinib_30min_R2 1 STNSPTIVSPAIVSPTQDSRPNMSR 25 1 A0A2U3U043 A0A2U3U043 1 S(0.01)T(0.01)NS(0.02)PT(0.921)IVS(0.04)PAIVSPTQDSRPNMSR 71.634 0.0012124 5474400.0 18641.0 11388.0 17834.0 21947.0 17023.0 12749.0 23995.0 18820.0 16274.0 15798.0 True False 17605.007845835426 12261.422981808631 16686.579856191052 18957.780739313275 14884.418552449124 14505.059026100775 25110.81504519047 18874.763084181286 19529.25473355214 15341.870691866543 1.1475137680027951 0.7992130313227706 1.0876496218311502 1.2356889925661867 0.9701827665866108 0.9454556955554708 1.636750533851319 1.2302778105272194 1.2729382958432527 1.0 13.905186786336351 -7.209414117789392 24.999288028939215 1.3041831095527314 1.0295384038154376 0.31538052720715715 0.18248366913379122 379.3766271097222 182298.97248753862 0.06823049040729108 0.052851057675196274 6.174273767587042e-08 7.209414117789392 -0.2746447057372938 STPCIQNGS(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 STPCIQNGSVK 11 0 Q9NXD2 Q9NXD2 MTMR10 Myotubularin-related protein 10 1 STPCIQNGS(1)VK 121.24 0.0044987 2910000.0 12277.0 9472.9 10690.0 10884.0 9857.2 7037.6 9351.6 8399.7 6953.1 8556.6 True False 11594.693488724946 10199.44096982569 10002.217038391966 9401.58042405275 8618.850411513922 8006.965519027911 9786.467929843857 8424.14173635481 8343.914285846227 8309.548725283283 1.3953457488546912 1.227436207070075 1.2037015930791088 1.1314188934769427 1.0372224408877384 0.9635860843640391 1.1777375948307258 1.0137905215866727 1.0041356711055056 1.0 13.020554413947211 -1.7406895908011593 0.4051489434502346 1.0159804274434496 6.359055264559836 0.8059855056476768 0.057098683110595544 26.866379687588847 0.42167229177429655 0.04189136829643095 112.46274042827132 0.018168137548090928 1.7406895908011593 5.3430748371163865 STPENHPET(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 STPENHPETPK 11 0 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 STPENHPET(1)PK;STPENHPET(1)PK;STPENHPET(1)PK 157.2 0.0017505 5951400.0 4792.03 6472.3 5539.99 5833.1 4523.46 5331.21 5598.1 4841.52 2617.34 4324.0599999999995 True False 4903.674975332787 5714.520107109364 4787.689786986796 4814.458585848081 4114.313841681727 5277.5828677513855 5175.8308099438345 4713.107162126655 4441.434817049832 4879.0952209111665 1.0050377689527916 1.1712253703550763 0.98126590488896 0.9867523317056693 0.8432534425744171 1.0816724472054475 1.0608177491107158 0.9659797459838233 0.9102988599227212 1.0 12.252397923981738 -5.3348520712932155 12.480838874460245 0.9795570957814601 1.0880997823227914 0.25856863840505684 0.07407570878205434 1.5001398324487414 253.0885650645549 0.01970106459987116 0.04102325336753884 4.625385437251555e-06 5.3348520712932155 0.10854268654133126 STPENHPET(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 STPENHPETPK 11 0 A0A590UJS4;Q6KC79-2;Q6KC79;Q6KC79-3 A0A590UJS4 NIPBL Nipped-B-like protein 1 STPENHPET(1)PK 145.81 0.005667899999999999 0.0 21542.0 19545.0 20338.0 23018.0 20470.0 17815.0 20276.0 20393.0 15931.0 20721.0 True False 20344.781879458544 21044.038652919695 19029.47522234012 19882.90869173522 17898.375595878126 20268.85454153154 21218.874176131787 20452.340253757106 19117.645149331416 20122.73089037643 1.0110348337058122 1.0457844299346006 0.9456706113105575 0.9880820252505637 0.8894605654363698 1.0072616212953973 1.0544728889794763 1.0163799518651968 0.950052219725023 1.0 14.296538488601927 -6.95800332995226 24.999582538391433 1.0100598014114641 0.9758178614586084 0.09363423144113736 0.04512979166085676 342.4476706532233 203849.54590834805 0.016761408968058604 0.014782162601718003 1.101530863522864e-07 6.95800332995226 -0.03424193995285574 STPES(ph)GDSDKESVGSSSTSNEGGR ddPTM_A459_Selumetinib_30min_R2 1 STPESGDSDKESVGSSSTSNEGGR 24 1 Q6GQQ9;Q6GQQ9-2 Q6GQQ9 OTUD7B OTU domain-containing protein 7B 1 S(0.07)T(0.07)PES(0.622)GDS(0.223)DKES(0.01)VGS(0.001)S(0.001)S(0.002)TSNEGGR 65.15100000000001 0.0015994000000000002 18327000.0 14825.0 14159.0 17607.0 16683.0 15027.0 10059.0 13592.0 15574.0 13179.0 14986.0 True False 14001.085849177105 15244.949771639298 16474.18478905214 14410.746620219777 13139.173916915513 11444.535943489504 14224.054932037046 15619.317761585511 15815.168252026779 14553.315241695927 0.9620547357528091 1.047524190774196 1.1319884518032586 0.9902037014172768 0.9028302966509766 0.7863868646712451 0.9773755804646123 1.0732480883005568 1.0867055368054959 1.0 13.82906021570314 -11.040716505482138 13.771965322481298 1.0000000014508665 0.9936620445295128 0.0 0.09461289192824392 4.730975942185762e-09 1.1155093375999066e-10 0.10309767518848764 0.025004853502611172 9.10507430850718e-12 11.040716505482138 -0.006337956921353749 STPESGDS(ph)DKESVGSSSTSNEGGR ddPTM_A459_Selumetinib_30min_R1 1 STPESGDSDKESVGSSSTSNEGGR 24 1 Q6GQQ9;Q6GQQ9-2 Q6GQQ9 OTUD7B OTU domain-containing protein 7B 1 S(0.015)T(0.015)PES(0.143)GDS(0.759)DKES(0.026)VGS(0.004)S(0.015)S(0.022)T(0.001)SNEGGR 76.611 0.00020962 17532000.0 2139.7 2319.7 2242.2 2533.2 1722.6 1918.9 2000.3 1735.4 1262.1 1736.2 True False 2189.5508468685643 2048.1084456007266 1937.7215555229893 2090.824174053309 1566.7911341497315 1899.5976082217976 1849.4157605492317 1689.3715546263566 2141.6915198631386 1959.058182020132 1.1176548338195622 1.0454556502700538 0.989108732607859 1.0672598666249427 0.7997675355073403 0.9696483880141731 0.9440330958635236 0.8623386329875709 1.093225070862714 1.0 10.93594452946792 -5.16886086310815 1.040239211756005 0.9458146775307946 1.1381165218392928 0.27647117074138783 0.0811853762381205 1.3271344573149009 1.7805761526954156 0.026967257651124784 0.24587869525363698 6.7785864147248025e-06 5.16886086310815 0.19230184430849817 STPFIVPS(ph)SPTEQEGR ddPTM_A459_Selumetinib_30min_R1 3 STPFIVPSSPTEQEGR 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 STPFIVPS(0.496)S(0.496)PT(0.008)EQEGR;STPFIVPS(0.499)S(0.499)PT(0.002)EQEGR;STPFIVPS(0.489)S(0.489)PT(0.022)EQEGR 245.39 2.7669999999999997e-22 284634600.0 10054.4 11318.5 11431.7 13002.0 12115.4 8752.7 10915.199999999999 10384.1 5606.56 8984.0 True False 10288.64795754325 9993.3247581721 9879.337929833271 10731.444777767701 11019.564209147602 8664.65578481575 10091.85767612206 10108.679935689492 9513.922833059094 10137.183911570597 1.0149414321860897 0.9858087655651294 0.9745643381843926 1.0586218886212386 1.087043927117654 0.8547399218954584 0.9955287152878027 0.9971881761118518 0.9385173353913298 1.0 13.30736930989147 -6.7357642842933805 24.999999637656863 0.9594148055440327 1.0212186250794024 0.3087369250670613 0.049973628839075704 323.70190688069937 315189.7938376847 0.017008513332886353 0.017002873261619304 1.837535405140085e-07 6.7357642842933805 0.06180381953536973 STPFIVPS(ph)SPTEQEGR ddPTM_A459_Selumetinib_30min_R2 3 STPFIVPSSPTEQEGR 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 STPFIVPS(0.952)S(0.047)PT(0.001)EQEGR;STPFIVPS(0.494)S(0.494)PT(0.012)EQEGR;STPFIVPS(0.499)S(0.499)PT(0.003)EQEGR 227.91 4.0107e-15 703027000.0 1355840.0 1357310.0 1530530.0 1568720.0 1619770.0 1151890.0 1151670.0 1208390.0 975400.0 1502670.0 True False 1280487.8406575576 1461411.3125604733 1432057.3661150625 1355057.6298070583 1416280.0116724747 1310552.3916836802 1205224.9369908106 1211906.2148402664 1170507.2549531003 1459284.012694464 0.8774767828047592 1.0014577695962565 0.981342462233154 0.9285770405344473 0.9705307529940073 0.898079044437579 0.825901556178532 0.8304800191722568 0.8021106547942247 1.0 20.476829263978296 -6.971862221997101 3.9010440889327067 0.8510483386445206 0.9546070271764621 0.31379611284432285 0.05960487681585877 0.21986721635679607 7.36225028987627 0.021413612870744104 0.017992666949137343 1.0669345478100173e-07 6.971862221997101 0.1035586885319415 STPFIVPSS(ph)PTEQEGR ddPTM_A459_Selumetinib_30min_R1 4 STPFIVPSSPTEQEGR 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 STPFIVPS(0.323)S(0.674)PT(0.003)EQEGR;STPFIVPS(0.225)S(0.773)PT(0.001)EQEGR;STPFIVPS(0.011)S(0.609)PT(0.38)EQEGR;STPFIVPS(0.224)S(0.762)PT(0.015)EQEGR 265.43 7.824e-40 848064200.0 16691.600000000002 18449.600000000002 20365.2 22318.0 21121.9 17239.600000000002 19389.199999999997 17117.500000000004 9900.1 14967.9 True False 17080.481803800223 16289.512255013666 17599.717698036187 18420.580260746 19211.427874374323 17066.185276304404 17926.657033665513 16663.488294523846 16799.74662530471 16889.175764692507 1.0113271388594136 0.964494211083263 1.0420708472244748 1.0906737260236792 1.1374994340775693 1.0104806483204434 1.0614287685454669 0.9866371530906517 0.9947049435310661 1.0 14.04381130217032 -10.179217790908545 9.75148761646629 0.9999919567591151 1.035036335313584 0.03804330624423491 0.049447600408776875 0.0 0.0 0.05245287307956885 0.012721690357304678 6.618844972338325e-11 10.179217790908545 0.03504437855446896 STPFIVPSS(ph)PTEQEGR ddPTM_A459_Selumetinib_30min_R2 3 STPFIVPSSPTEQEGR 16 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 STPFIVPS(0.223)S(0.763)PT(0.014)EQEGR;STPFIVPS(0.034)S(0.943)PT(0.022)EQEGR;STPFIVPS(0.307)S(0.693)PT(0.001)EQEGR 241.66 1.4177e-21 138048000.0 201780.0 193006.0 241938.0 253231.0 254485.0 198019.0 182452.0 202329.0 168100.0 197822.0 True False 190565.87538933932 207808.93958789576 226371.97248217702 218740.50095215888 222514.31917523444 225294.3198124911 190936.37952177937 202917.7438926309 201724.6971064342 192110.3648567175 0.9919604053194625 1.0817164380635411 1.1783433582618668 1.1386189449762538 1.1582629565104061 1.1727338084049934 0.993889005750347 1.0562560955207905 1.0500458799132852 1.0 17.55157583271143 -7.266340239974912 24.99313527214972 1.0297357524435857 1.123720428946497 0.42514201554765496 0.05404739177656889 452.2681923175847 2306443.4392287987 0.023622506498884963 0.016525849893114175 5.4157643612129386e-08 7.266340239974912 0.09398467650291131 STPKEDDSSASTSQS(ph)TR ddPTM_A459_Selumetinib_30min_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 STPKEDDS(0.063)S(0.063)AS(0.005)T(0.143)S(0.143)QS(0.433)T(0.151)R 96.455 0.0032919000000000004 5857000.0 410.83 626.92 755.36 912.05 884.15 556.87 556.04 553.67 126.82 300.57 True False 420.40153966397713 553.5199149527989 652.7862608954795 752.7775887988797 804.1787886093604 551.2683933975053 514.0974551296277 538.984873026377 215.20427743367676 339.1510872997301 1.2395700777820025 1.6320747173769696 1.9247653489566123 2.2195936176775417 2.371152028472357 1.6254360196413382 1.5158360812663003 1.589217588295805 0.6345380731257589 1.0 8.40578430779368 -7.9839460708693935 1.5785258203832604 0.8265531889916689 1.8540612206607792 0.5569619844505089 0.3333910599557651 0.31536910440307653 1.4128120680031582 0.31582732356569915 0.10615151112665994 1.0376572603738195e-08 7.9839460708693935 1.0275080316691103 STPKEDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R1 3 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 ;; 167.92 3.5193e-06 10765800.0 1366.1100000000001 1407.02 2563.56 2701.5 2049.4 1709.24 1714.21 1548.57 1059.84 1521.91 False True 1397.9377050126716 1242.2854442941486 2215.4426326271137 2229.7337384355837 1864.0321318509582 1692.04659746575 1584.9057595816103 1507.4968931357246 1798.4710723490616 1717.2619731587706 0.8140503469259692 0.7234105591991074 1.2901017242884487 1.2984237543757875 1.085467541345608 0.9853165235781476 0.9229260208134107 0.877849109045838 1.0472898721683757 1.0 10.745894427989944 -6.937271577102335 5.328797791092313 0.9519952036227034 1.0520459161308098 0.04385444432872898 0.17346760261035238 0.6990792407283551 39.10768749186878 0.07035435333693581 0.06146158225132444 1.1553895172260145e-07 6.937271577102335 0.10005071250810638 STPKEDDSSASTSQSTR ddPTM_A459_Selumetinib_30min_R2 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588;P23588-2;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 87.13799999999998 0.030413 956930.0 2629.6 4809.1 3530.7 2442.3 2712.0 1980.8 1864.8 2588.8 985.07 4477.6 False True 2483.457359122839 5177.942506306274 3303.5386059354996 2109.654526797504 2371.2943144123838 2253.637220087883 1951.516895031098 2596.3329794010897 1182.1115251554754 4348.3200537980565 0.5711303051286792 1.190791487803107 0.7597275649132614 0.485165420368452 0.5453357354275631 0.5182776778630716 0.4487978968628444 0.5970887485923013 0.27185476472067777 1.0 12.086242417077424 -5.600082030336038 4.680708680657815 0.5311553907597909 0.9023394304666217 0.2648567684691553 0.22254851906927964 0.2131345014520617 8.595931357015917 0.05625561018630056 0.10138417968449408 2.511412026610963e-06 5.600082030336038 0.3711840397068308 STPLAS(ph)PSPSPGR ddPTM_A459_Selumetinib_30min_R2 2 STPLASPSPSPGR 13 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 ST(0.002)PLAS(0.991)PS(0.007)PSPGR;S(0.012)T(0.065)PLAS(0.922)PS(0.001)PSPGR 116.19 0.0038588 11762000.0 40983.0 34852.0 52718.0 53278.0 69982.0 40857.0 34569.0 46443.0 47010.0 42161.0 True False 38705.32892794775 37525.036333157215 49326.181275018476 46021.44449032362 61190.23551298215 46484.68088708129 36176.526997174005 46578.141440947475 56413.313569146245 40943.702382566495 0.9453304580591171 0.9165032507938285 1.204731824546018 1.124017658694178 1.494496881137854 1.135331642769905 0.8835675547646049 1.1376143028232855 1.3778263880983705 1.0 15.32135394520973 -5.258922494934233 24.5109506969545 1.1731352456766497 0.9309168248398755 0.2555248977852238 0.16294608575898162 231.1407385923287 2250943.032483029 0.04385400189338402 0.10540125329877306 5.509060034252862e-06 5.258922494934233 -0.24221842083677425 STPLASPS(ph)PSPGRSPQR ddPTM_A459_Selumetinib_30min_R1 2 STPLASPSPSPGRSPQR 17 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 STPLASPS(0.917)PS(0.074)PGRS(0.009)PQR;STPLASPS(0.846)PS(0.147)PGRS(0.007)PQR 140.45 0.0023918000000000003 53318000.0 6770.4 11195.2 10459.0 12964.5 9613.1 10194.7 8741.2 6894.5 3998.3 5822.4 True False 6928.137147094887 9884.460779492718 9038.72524717462 10700.493448805515 8743.59680233065 10092.150574046995 8081.844246419502 6711.635463507793 6784.823075722048 6569.761754978697 1.0545492219477526 1.504538695334283 1.3758071577443265 1.6287490852611917 1.330884913095148 1.5361516825779808 1.2301578881905297 1.021594954858383 1.0327350258295702 1.0 12.681625338445173 -7.573331456700511 3.2909947939036335 1.0200212678674196 1.4148303878016708 0.5879300139246157 0.1447301195919435 0.16668026561166366 3.702249208625942 0.07276192791382957 0.03992820133551033 2.670967129068172e-08 7.573331456700511 0.39480911993425116 STPLKPMFGNSEIVS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 STPLKPMFGNSEIVSPTK 18 1 Q63HK5 Q63HK5 TSHZ3 Teashirt homolog 3 1 STPLKPMFGNS(0.001)EIVS(0.836)PT(0.163)K 76.186 0.008145300000000001 2851900.0 13253.0 10338.0 13905.0 11064.0 13921.0 10659.0 12728.0 11810.0 12681.0 13662.0 True False 12516.451315962498 11130.891358090757 13010.367438619287 9557.064113535434 12172.119524680966 12127.180497231802 13319.877220053526 11844.365144749243 15217.554336744173 13267.542561861046 0.9433888195650008 0.8389565216159683 0.9806162202199346 0.7203341590181309 0.9174358754025037 0.9140487351510493 1.0039445630529138 0.892732402366443 1.1469761084836194 1.0 13.695613556426911 -7.571333964649492 1.0517929301465339 1.0438907423278374 0.8760409025750532 0.3617141302570416 0.0852632811108112 0.5819959652903939 1.1840230087782673 0.0669758640057978 0.030101691952506605 2.6832802578162617e-08 7.571333964649492 -0.16784983975278422 STPS(ph)PTPVESSDPK ddPTM_A459_Selumetinib_30min_R1 1 STPSPTPVESSDPK 14 0 Q9NW07 Q9NW07 ZNF358 Zinc finger protein 358 1 ST(0.001)PS(0.977)PT(0.022)PVESSDPK 169.3 0.00018036 14324000.0 5127.5 5771.2 6194.4 6586.9 5230.2 4830.5 5456.6 5609.5 2858.0 4467.2 True False 5246.960773621798 5095.505221041912 5353.234503403622 5436.621566426553 4757.12933346681 4781.909555743079 5045.004268866134 5460.717837776049 4849.8172599388745 5040.608634212839 1.0409379411066266 1.0108908647373385 1.0620214525422291 1.07856450697755 0.9437608984712819 0.9486770155663633 1.0008720444240522 1.083344935909474 0.9621491394949849 1.0 12.299382228813158 -6.25040828883601 24.99381023067384 0.9924653036508766 1.0464397563686536 0.3339522826487278 0.04020440375861547 1034.2178858194945 2343287.309780607 0.01289191561195377 0.016494593716736023 5.618129054111106e-07 6.25040828883601 0.05397445271777701 STPS(ph)PTPVESSDPK ddPTM_A459_Selumetinib_30min_R2 1 STPSPTPVESSDPK 14 0 Q9NW07 Q9NW07 ZNF358 Zinc finger protein 358 1 STPS(0.993)PT(0.006)PVES(0.001)SDPK 173.33 0.00010617 14070000.0 63096.0 54445.0 60991.0 58952.0 63699.0 44541.0 48256.0 52672.0 40017.0 52062.0 True False 59589.376913300395 58620.756431732596 57066.905461979826 50922.63590212767 55696.56214371475 50676.11844705897 50499.99961744995 52825.266799681005 48021.51816840089 50558.83478667912 1.1786145223623818 1.1594562390345589 1.1287227188435007 1.0071955992851402 1.101618784901057 1.0023197461111337 0.9988363029037869 1.0448276156395722 0.9498145748614693 1.0 15.625675594115677 -5.152486224396512 0.4962368955685361 0.9916491206524147 1.2831374707499243 0.7670190467324571 0.03617257500762854 1.5093472656730837 0.3736278904934091 0.023881631402558494 0.24623179718774454 7.039045550823514e-06 5.152486224396512 0.2914883500975096 STPS(ph)PVLQPR ddPTM_A459_Selumetinib_30min_R1 2 STPSPVLQPR 10 0 Q8TEK3-1;Q8TEK3 Q8TEK3-1 DOT1L Histone-lysine N-methyltransferase, H3 lysine-79 specific 1 S(0.019)T(0.055)PS(0.926)PVLQPR;S(0.002)T(0.012)PS(0.986)PVLQPR 114.76 0.0068572 22356000.0 8583.3 11366.7 10703.3 11865.099999999999 12428.9 9409.8 9807.5 9174.2 5488.4 7744.6 True False 8783.27418980556 10035.881479764537 9249.85064901846 9793.083020511578 11304.708189500523 9315.145955414804 9067.71237893645 8930.870413998578 9313.413943124046 8738.694848792251 1.005101372892025 1.148441689911116 1.0584933801981717 1.1206573967810596 1.2936380529482516 1.0659653548495542 1.0376506487338522 1.0219913349226157 1.065767154509489 1.0 13.093202109493323 -6.987360585030479 24.995499200798115 1.0358453015511833 1.1283095691671599 0.28223626789838974 0.07087123538269369 314.39514979076273 621739.6311981194 0.02560942833864309 0.02257159213784754 1.0295309688627774e-07 6.987360585030479 0.09246426761597659 STPSHGSVSSLNSTGS(ph)LSPK ddPTM_A459_Selumetinib_30min_R2 1 STPSHGSVSSLNSTGSLSPK 20 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 STPSHGSVSSLNS(0.003)T(0.148)GS(0.724)LS(0.124)PK 146.45 1.5906e-05 33270000.0 22746.0 25405.0 63872.0 95162.0 111560.0 58813.0 37724.0 51236.0 62926.0 78788.0 True False 21481.868379452426 27353.48181004989 59762.54505857543 82200.7714363936 97544.83544094594 66913.95689874215 39478.24074868787 51385.08827742358 75512.95829934254 76513.18572419185 0.2807603444573386 0.35750023412502213 0.7810751113409695 1.0743347131395609 1.2748761473946095 0.8745415089622307 0.5159665013948791 0.6715847443949351 0.9869273849287253 1.0 16.22342077231771 -5.291160045855718 3.393415184443456 0.8987767663416014 0.29685494355303677 0.5840867969910282 0.1978188464115468 0.18863853311761178 4.509125805695922 0.06081049591635016 0.16051111666988918 5.114933056993826e-06 5.291160045855718 -0.6019218227885647 STPSHGSVSSLNSTGSLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 STPSHGSVSSLNSTGSLSPK 20 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 STPSHGSVSSLNSTGS(0.001)LS(0.999)PK 263.16 4.8487e-48 33684000.0 24173.0 21316.0 50713.0 79125.0 95961.0 46841.0 36153.0 40257.0 49993.0 66841.0 True False 22829.561432186045 22950.868658257183 47450.18079213952 68348.03850176177 83905.52127777527 53292.922569737784 37834.18613581045 40374.14120509489 59992.99692113019 64911.126656225606 0.3517049018898283 0.35357372211095295 0.7310022678151834 1.052947961660538 1.2926215519589648 0.8210136738494968 0.5828613380288907 0.6219910712522292 0.9242328705655932 1.0 15.986178176662639 -5.356250173580504 3.478559526545009 0.8839197258111335 0.345177223006592 0.550619488507442 0.1941970722400429 0.20421920196240628 4.596125852109511 0.060101816676443896 0.14404754228921088 4.403011567389312e-06 5.356250173580504 -0.5387425028045416 STPSPT(ph)PVESSDPK ddPTM_A459_Selumetinib_30min_R2 1 STPSPTPVESSDPK 14 0 Q9NW07 Q9NW07 ZNF358 Zinc finger protein 358 1 STPS(0.395)PT(0.592)PVES(0.012)S(0.001)DPK 126.56 0.003011 14396000.0 102130.0 95591.0 107040.0 100800.0 94239.0 76023.0 82262.0 87187.0 48495.0 79861.0 True False 96454.02345878302 102922.52232648987 100153.16293633994 87070.86611030121 82399.85431265074 86494.478181917 86087.34599906065 87440.69973541511 58195.35506351303 77555.20542620316 1.2436821349221083 1.3270872246534724 1.2913789910806133 1.122695319183347 1.0624671014643556 1.1152633495919229 1.1100137705260307 1.1274639691157595 0.7503732953023793 1.0 16.24293599627873 -6.343701941628514 0.4239154473103137 0.9397219186111987 1.3641535940020382 0.600657604492379 0.09827082722394899 1.188832743804557 0.39524514749225487 0.0953264160600819 0.22134815958719087 4.5320851235487803e-07 6.343701941628514 0.4244316753908395 STPSSS(ph)PSLR ddPTM_A459_Selumetinib_30min_R2 1 STPSSSPSLR 10 0 Q96CP6-2;Q96CP6-3;Q96CP6;M0QZ12;S4R3I2;M0R0J9 Q96CP6-2 GRAMD1A GRAM domain-containing protein 1A 1 ST(0.001)PS(0.193)S(0.126)S(0.65)PS(0.03)LR 103.31 0.014356 4570900.0 41126.0 25848.0 40264.0 38573.0 37261.0 19984.0 37096.0 34279.0 37015.0 38273.0 True False 38840.3815604221 27830.458485580377 37673.458076128554 33319.290857863554 32579.940062433587 22736.614603309907 38821.03750432948 34378.74621480605 44419.034285512644 37167.95904480369 1.0449963505825652 0.7487755368012666 1.0136003978780626 0.8964519902128388 0.8765598353990993 0.6117262068628067 1.0444759008029767 0.9249565243376583 1.1950894110695782 1.0 15.181771849110918 -7.777122282217273 2.1166684831802116 1.075131652556306 0.8715284852790097 0.2566116044110057 0.13531781076665195 0.43290983086007223 3.807239488389923 0.09221195069982412 0.037984001333136626 1.6706201595648586e-08 7.777122282217273 -0.20360316727729622 STQIENQHQGAQDTSDLMS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 4 STQIENQHQGAQDTSDLMSPSKR 23 1 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 STQIENQHQGAQDT(0.006)S(0.024)DLMS(0.801)PS(0.168)KR;STQIENQHQGAQDT(0.022)S(0.007)DLMS(0.86)PS(0.11)KR;STQIENQHQGAQDTS(0.001)DLMS(0.742)PS(0.257)KR;STQIENQHQGAQDT(0.092)S(0.092)DLMS(0.561)PS(0.255)KR 124.39 5.3397e-06 55354000.0 4785.530000000001 5357.58 6344.55 6601.84 5103.23 5003.8099999999995 5014.16 4592.459999999999 2557.99 4051.58 True False 4897.023537979586 4730.312042928631 5482.994958118532 5448.95257588509 4641.643747548436 4953.4762144959695 4635.937874276624 4470.653042387554 4340.722201802323 4571.63975873121 1.0711744136503618 1.0347079587568941 1.1993497404616706 1.1919033133523549 1.01531266515117 1.0835228661741125 1.0140645630318121 0.9779101762883251 0.9494891178842633 1.0 12.158496009568777 -7.157527818413001 1.2053246811267735 0.9706311915800059 1.1146530651650903 0.5220221220936216 0.0554820541710229 0.40863734027194026 1.1791073171951796 0.037369547353256816 0.02339108735823503 6.957803855733305e-08 7.157527818413001 0.14402187358508445 STQIENQHQGAQDTSDLMS(ph)PSKR ddPTM_A459_Selumetinib_30min_R2 5 STQIENQHQGAQDTSDLMSPSKR 23 1 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 STQIENQHQGAQDT(0.017)S(0.013)DLMS(0.757)PS(0.212)KR;STQIENQHQGAQDT(0.006)S(0.014)DLMS(0.49)PS(0.49)KR;STQIENQHQGAQDT(0.012)S(0.015)DLMS(0.486)PS(0.486)KR;STQIENQHQGAQDT(0.02)S(0.006)DLMS(0.741)PS(0.233)KR;STQIENQHQGAQDT(0.105)S(0.105)DLMS(0.395)PS(0.395)KR 61.429 0.0053357 91904400.0 210389.0 215282.0 222566.0 223762.3 231811.0 176715.3 198137.5 193349.7 139033.5 221260.2 True False 198696.42163389694 231793.43715926667 208246.34587153795 193285.48872850186 202688.82976336608 201056.2285132253 207351.28635200797 193912.31561623426 166844.08492056778 214871.84312296007 0.9247206090199228 1.078752030933263 0.9691653538447534 0.8995384686950098 0.9433010245431632 0.9357030013382033 0.9649998033169546 0.9024556814792539 0.7764818437615929 1.0 17.713116918355126 -5.562653160977273 5.546166092431815 0.9178877584465426 1.0071360019615947 0.21912559398955822 0.06516021699160537 0.24286449263868198 18.626650706140726 0.017512589818075658 0.03151216885156963 2.737454056537538e-06 5.562653160977273 0.08924824351505212 STQS(ph)EDFSR ddPTM_A459_Selumetinib_30min_R2 1 STQSEDFSR 9 0 Q9UJF2-2;Q9UJF2;H0Y638 Q9UJF2-2 RASAL2 Ras GTPase-activating protein nGAP 1 S(0.002)T(0.047)QS(0.95)EDFSR 84.18799999999997 0.036903 6255300.0 24547.0 18680.0 24890.0 28609.0 29760.0 18673.0 15558.0 20239.0 22509.0 20815.0 True False 23182.77600942667 20112.69593433309 23288.604498182987 24712.40484672226 26021.282742224405 21245.036253383012 16281.477827592156 20297.892139253185 27011.428954007955 20214.01686613511 1.1468663632246778 0.9949875904194102 1.1521017644542875 1.2225380541817683 1.2872890586045918 1.0510051710194814 0.805454845289498 1.0041493619834954 1.3362722081854332 1.0 14.303068417596714 -6.977967001525909 24.880274280476847 1.0213027342771817 1.1559635479607016 0.15624201852846742 0.13936771900990716 421.92327929629135 476445.939670757 0.05186696657021954 0.04573911007546844 1.0520418068108649e-07 6.977967001525909 0.1346608136835199 STS(ph)ADSASSSDTSR ddPTM_A459_Selumetinib_30min_R2 2 STSADSASSSDTSR 14 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182;I3L1I8;Q9UQ35-3;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.047)T(0.008)S(0.83)ADS(0.057)AS(0.057)SSDTSR;S(0.072)T(0.072)S(0.856)ADSASSSDTSR 211.83 3.2757e-06 3901900.0 15199.6 14669.5 14364.2 16367.8 16470.0 13290.6 18039.4 22482.3 15396.0 20221.2 True False 14354.867080819711 15794.603480123076 13440.023010558445 14138.4774039701 14400.89135633184 15121.25950994549 18878.26784439296 22547.71977085487 18475.630200182444 19637.36141501277 0.7309977535905313 0.8043139374136129 0.6844108394462579 0.7199784688568817 0.7333414633455977 0.7700250145819123 0.961344421250022 1.1482051633279577 0.9408407682540191 1.0 14.261313473702693 -7.3076632824062875 3.146391300577885 1.0365936925347048 0.7362912222993563 0.8514751396150659 0.0561996081229013 0.08659819163214418 1.7263880911134237 0.024296221411851192 0.016071551356605672 4.9242117214916207e-08 7.3076632824062875 -0.3003024702353485 STS(ph)DTDLVTSDSR ddPTM_A459_Selumetinib_30min_R1 3 STSDTDLVTSDSR 13 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 STS(0.992)DT(0.008)DLVTSDSR;S(0.002)T(0.002)S(0.993)DT(0.003)DLVTSDSR;S(0.023)T(0.023)S(0.942)DT(0.011)DLVTSDSR 298.91 6.9600999999999966e-74 44058000.0 6692.5 7132.5 8631.2 9711.7 8256.900000000001 6769.0 7200.199999999999 6205.4 3989.8299999999995 5550.4 True False 6848.422228661901 6297.423584190707 7459.1304477878975 8015.7339061872435 7510.0648528741 6700.910005760254 6657.083117085718 6040.812634020053 6770.450104346364 6262.847905474336 1.093499687686127 1.005520759762687 1.191012548982372 1.2798864074570158 1.1991453355125512 1.0699461502015735 1.0629482333854512 0.9645472355699071 1.0810497407143378 1.0 12.612603127889889 -7.0062955524914265 3.1252736960725813 1.0253793569406784 1.1540981260953884 0.3960399151278168 0.07378754725277929 0.30317881373427075 6.0873801233110925 0.03296122592131186 0.026624668244934376 9.856085164920273e-08 7.0062955524914265 0.12871876915471003 STS(ph)DTDLVTSDSR ddPTM_A459_Selumetinib_30min_R2 3 STSDTDLVTSDSR 13 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 ST(0.016)S(0.867)DT(0.117)DLVTSDSR;ST(0.001)S(0.999)DTDLVTSDSR;S(0.001)T(0.057)S(0.941)DTDLVTSDSR 320.48 2.572999999999999e-103 107429000.0 410617.0 374940.0 404188.0 420142.0 470881.0 347941.0 363415.0 368244.0 336378.0 408986.0 True False 387796.55097008793 403696.69237788225 378182.984126621 362917.93481462385 411724.7190504487 395866.7144560772 380314.5175931613 369315.5290739242 403662.9991866039 397177.511506757 0.9763809373267865 1.0164137713799397 0.9521762264230993 0.913742405600549 1.0366264632871698 0.9966997198665476 0.9575429287282072 0.9298500503537225 1.0163289398114288 1.0 18.59942441312343 -5.26027497634597 24.997994139594596 0.972977206438363 0.9963973521762423 0.04492350478168594 0.03750268667474827 334.68319873141616 7184895.826984185 0.009903100890982454 0.02324180420162006 5.491930386456315e-06 5.26027497634597 0.023420145737879206 STS(ph)EGAWPQLPSGLSMMR ddPTM_A459_Selumetinib_30min_R1 1 STSEGAWPQLPSGLSMMR 18 0 G3V1A6;P57764 G3V1A6 GSDMD Gasdermin-D 1 S(0.084)T(0.084)S(0.831)EGAWPQLPSGLSMMR 191.44 2.4057e-10 39156000.0 1755.8 1531.5 1958.5 1839.1 1944.2 1583.2 1519.4 1813.7 1070.0 1391.7 True False 1796.7067238079283 1352.1912680249661 1692.546457270437 1517.9357091826316 1768.3474532763887 1567.2744454305857 1404.7904347240415 1765.5947842721118 1815.7118502920218 1570.3382513059667 1.1441526832284084 0.8610828061409195 1.0778228549567817 0.9666297741395813 1.1260933444152865 0.9980489516364816 0.8945782436081857 1.1243404297155475 1.1562552518745506 1.0 10.6168596341745 -7.8453011499632685 24.999999377653374 1.1052253671249934 1.0090108827780597 0.14042644627568324 0.09361777377059403 45.40536310914881 13530.520111051788 0.04850008035713044 0.023298688809323252 1.4279034734334976e-08 7.8453011499632685 -0.09621448434693369 STS(ph)EGAWPQLPSGLSMMR ddPTM_A459_Selumetinib_30min_R2 2 STSEGAWPQLPSGLSMMR 18 0 G3V1A6;P57764 G3V1A6 GSDMD Gasdermin-D 1 STS(1)EGAWPQLPSGLSMMR;S(0.026)T(0.026)S(0.948)EGAWPQLPSGLSMMR 238.88 6.055899999999999e-25 15366000.0 29462.0 24721.0 34591.0 42208.0 42590.0 25095.0 29710.0 33255.0 20176.2 27484.0 True False 27824.619985730584 26617.021209456532 32365.452719833156 36459.19758713876 37239.46344056913 28551.608460271324 31091.573869248146 33351.7665443384 24212.00377012995 26690.465507992158 1.042492869875155 0.9972482945824368 1.212622264311639 1.3660008131451087 1.395234692681482 1.0697306291537654 1.1648944024576164 1.2495760530797635 0.9071405578475183 1.0 14.704036847270437 -8.263378063524456 24.995568096432415 0.9535702564031955 1.189971040359711 0.3595676398927684 0.12468977409649055 211.01710916278932 2720552.884557946 0.11276641328862416 0.03483578288579353 5.452829728136954e-09 8.263378063524456 0.23640078395651554 STS(ph)FGVPNANSIK ddPTM_A459_Selumetinib_30min_R1 2 STSFGVPNANSIK 13 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6;P53814-2;H7BZZ8;A0A096LNK9;B5MCI0 A0A087WVP4 SMTN Smoothelin 1 STS(0.999)FGVPNANSIK;S(0.003)T(0.003)S(0.995)FGVPNANSIK 182.37 0.00011757 36280000.0 3160.3 3076.7 3772.0 3925.7999999999997 3711.3 3050.0 2878.3999999999996 2883.2 2149.8 2262.3999999999996 True False 3233.9288411266652 2716.478533680975 3259.783118112884 3240.232726392897 3375.613570283235 3019.3197691784258 2661.279970586864 2806.728170046509 3648.0535848203617 2552.801077642175 1.2668158398435005 1.0641168077968597 1.2769436469854885 1.2692852391717293 1.3223175122603081 1.1827477650421307 1.042494064224104 1.0994699879392353 1.4290395036145105 1.0 11.317865407412905 -6.993825352149326 24.82685089203582 1.1455516007353694 1.2356924120021333 0.11943089382574112 0.12451342761549851 358.4505701683708 1441236.7805026397 0.0441329470656874 0.03881870911889301 1.0143192036149722e-07 6.993825352149326 0.09014081126676388 STS(ph)FGVPNANSIK ddPTM_A459_Selumetinib_30min_R2 2 STSFGVPNANSIK 13 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6;P53814-2;H7BZZ8;A0A096LNK9;B5MCI0 A0A087WVP4 SMTN Smoothelin 1 S(0.001)T(0.003)S(0.996)FGVPNANSIK;S(0.074)T(0.074)S(0.852)FGVPNANSIK 209.11 8.8447e-06 24458000.0 146820.0 151771.0 183570.0 189832.0 194242.0 117129.0 136385.0 143965.0 119714.0 144205.0 True False 138660.33216702746 163411.3476793182 171759.30605590352 163976.55412153425 169839.58341448772 133262.45655880123 142727.17274175058 144383.91431531115 143660.14508863588 140041.42696041407 0.9901379554367365 1.1668786246052045 1.2264892595278627 1.1709146191996886 1.2127810113110085 0.9515931067774033 1.0191782234702285 1.0310085911658453 1.0258403402961949 1.0 17.095494141817326 -6.760712328488607 24.99999817903275 1.0083154699866306 1.1592159449962998 0.5742263272128032 0.06356458549142935 14.829392723776865 509922.62060629105 0.022267863844781965 0.021029369476900234 1.7349528293928256e-07 6.760712328488607 0.1509004750096692 STS(ph)FRGGMGSGGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R1 8 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.155)T(0.155)S(0.663)FRGGMGS(0.026)GGLAT(0.002)GIAGGLAGMGGIQNEK;S(0.185)T(0.185)S(0.5)FRGGMGS(0.052)GGLAT(0.078)GIAGGLAGMGGIQNEK;S(0.177)T(0.177)S(0.561)FRGGMGS(0.073)GGLAT(0.011)GIAGGLAGMGGIQNEK;S(0.071)T(0.071)S(0.852)FRGGMGS(0.006)GGLATGIAGGLAGMGGIQNEK;S(0.059)T(0.059)S(0.333)FRGGMGS(0.302)GGLAT(0.248)GIAGGLAGMGGIQNEK;S(0.215)T(0.124)S(0.627)FRGGMGS(0.022)GGLAT(0.012)GIAGGLAGMGGIQNEK;S(0.194)T(0.063)S(0.744)FRGGMGSGGLATGIAGGLAGMGGIQNEK;S(0.107)T(0.107)S(0.469)FRGGMGS(0.135)GGLAT(0.183)GIAGGLAGMGGIQNEK 124.93 2.7055000000000004e-18 2578694000.0 16636.74 16553.39 26640.46 35858.5 24777.86 17334.510000000002 13906.73 13195.61 8257.39 10969.45 True False 17024.343672539188 14615.311403337766 23022.831857572008 29596.48612241064 22536.70693788649 17160.140567875787 12857.734159727439 12845.619557417946 14012.187734096096 12377.485758991326 1.3754282577277266 1.1807980786987233 1.8600572285730668 2.3911549323262995 1.820782295912984 1.3863995404244531 1.0388001578096948 1.0378213966504914 1.132070600357369 1.0 13.595430668946925 -7.009118709592592 3.245632755771708 1.059706700925386 1.7370926375867264 0.5257909560524341 0.30082695077110266 0.2353953606841549 5.137683763723162 0.1372286012187753 0.11088306105581601 9.792222892435741e-08 7.009118709592592 0.6773859366613404 STS(ph)FRGGMGSGGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R2 7 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.065)T(0.195)S(0.667)FRGGMGS(0.05)GGLAT(0.024)GIAGGLAGMGGIQNEK;S(0.148)T(0.148)S(0.5)FRGGMGS(0.102)GGLAT(0.102)GIAGGLAGMGGIQNEK;S(0.14)T(0.155)S(0.591)FRGGMGS(0.114)GGLAT(0.001)GIAGGLAGMGGIQNEK;S(0.198)T(0.225)S(0.549)FRGGMGS(0.028)GGLAT(0.001)GIAGGLAGMGGIQNEK;S(0.047)T(0.177)S(0.592)FRGGMGS(0.082)GGLAT(0.102)GIAGGLAGMGGIQNEK;S(0.172)T(0.172)S(0.578)FRGGMGS(0.034)GGLAT(0.045)GIAGGLAGMGGIQNEK;S(0.174)T(0.174)S(0.643)FRGGMGS(0.007)GGLAT(0.001)GIAGGLAGMGGIQNEK 98.112 2.1211e-08 340719200.0 378613.0 568596.0 607116.0 539857.0 565990.0 199519.8 131631.6 131669.5 100013.7 542941.0 True False 357571.2051679253 612205.4848757 568054.8175379218 466327.5452947297 494885.2761852012 227001.84138958546 137752.73022306722 132052.63644594085 120019.23461626291 527264.8825998675 0.6781623752463714 1.161096642463656 1.0773613724034208 0.8844274684013383 0.9385894879723315 0.43052713897855655 0.26125906497665513 0.25044838145640996 0.22762607292271253 1.0 19.008168386598975 -6.774248113245155 4.477988870272191 0.36893283333593 0.9682045131622288 0.5233479508308257 0.24173374850310744 0.13789054903164435 6.6444557902079895 0.08148599621370185 0.07537143908804078 1.6817130207983501e-07 6.774248113245155 0.5992716798262987 STS(ph)GPRPGCQPSSPCVPK ddPTM_A459_Selumetinib_30min_R2 1 STSGPRPGCQPSSPCVPK 18 1 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 S(0.16)T(0.16)S(0.68)GPRPGCQPS(0.001)SPCVPK 69.081 0.014468 8198900.0 15605.0 11446.0 14699.0 16029.0 19916.0 8696.4 12868.0 15258.0 11713.0 12693.0 True False 14737.736571764497 12323.871395309236 13753.282343061137 13845.82254843271 17413.974028700977 9894.250161940767 13466.387497458276 15302.398253902129 14055.927288564353 12326.520109625402 1.1956120981992517 0.9997851206753723 1.1157473659026946 1.1232547730661577 1.4127242623084626 0.8026799189022252 1.0924727642266845 1.2414207836283782 1.1402997085599618 1.0 13.58947795064664 -10.603277407124173 4.802454992103654 0.9999953088701488 1.1223551580924704 0.05915762843025352 0.14910819170818365 7.411869516239673e-06 1.4191316386634262e-06 0.1428774034259629 0.0346515318241567 2.4930018046045854e-11 10.603277407124173 0.12235984922232168 STS(ph)LSALVR ddPTM_A459_Selumetinib_30min_R1 3 STSLSALVR 9 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.013)T(0.044)S(0.921)LS(0.022)ALVR;S(0.06)T(0.208)S(0.721)LS(0.01)ALVR;S(0.022)T(0.04)S(0.926)LS(0.012)ALVR 150.15 0.0013502 62227500.0 9797.8 11530.599999999999 11622.0 11770.6 11233.3 9909.0 12775.0 12630.8 7521.799999999999 8349.0 True False 10026.069676799927 10180.591991569489 10043.796235076346 9715.085671526876 10217.249998400197 9809.324456652144 11811.371464788499 12295.790153379392 12763.945229464041 9420.6754761468 1.0642622922513347 1.0806647588431213 1.0661439575651759 1.0312514953015337 1.0845559879724471 1.041254895308665 1.2537711860147347 1.305191988038692 1.354886415712166 1.0 13.201614791543632 -7.265411142475499 24.051483813841674 1.2538950848122579 1.0621371030802618 0.4474868657848051 0.08919069067473491 158.45257204486327 959518.9347752443 0.034204066495417546 0.02406155972079115 5.427362849052863e-08 7.265411142475499 -0.1917579817319961 STS(ph)LSALVR ddPTM_A459_Selumetinib_30min_R2 4 STSLSALVR 9 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5;X6R5W5;A0A0A0MRX3 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 S(0.054)T(0.189)S(0.654)LS(0.103)ALVR;S(0.008)T(0.031)S(0.859)LS(0.102)ALVR;S(0.212)T(0.136)S(0.593)LS(0.059)ALVR;S(0.018)T(0.219)S(0.761)LS(0.002)ALVR 134.84 0.0027851 25856000.0 146633.0 110905.0 149847.0 162481.0 157972.0 129700.0 125565.0 155029.0 128200.0 176083.0 True False 138483.72487840708 119411.05688421913 140206.00716107796 140350.80750464147 138126.14507240168 147564.99770062513 131404.02130232716 155480.10872356757 153843.58220728693 170999.02627142295 0.809850955867988 0.6983142506009398 0.8199228394349573 0.8207696298917267 0.8077598339838329 0.8629581168865751 0.7684489448130102 0.9092455794267358 0.8996751944253439 1.0 17.383628584358576 -8.513231666790714 0.24504646094972027 1.0505154890795376 0.7366510751507718 0.6989350369371776 0.043342619992762774 1.5470167567637503 0.3169976687197666 0.17675221848583564 0.10840019568163642 3.0673853088907203e-09 8.513231666790714 -0.31386441392876585 STS(ph)PAGQHHS(ph)PISSR ddPTM_A459_Selumetinib_30min_R2 1 STSPAGQHHSPISSR 15 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 2 S(0.256)T(0.326)S(0.418)PAGQHHS(0.981)PIS(0.016)S(0.003)R 88.57 0.025203 0.0 30477.0 23483.0 30129.0 33821.0 35550.0 25662.0 33154.0 44739.0 29868.0 39584.0 True False 28783.210349097506 25284.07059025394 28190.532941974896 29214.52145552079 31083.891178967635 29196.707563557793 34695.7266934047 44869.183083059834 35842.43458164774 38441.107068416626 0.7487612231840719 0.6577352349726535 0.7333434204119568 0.7599812722231292 0.8086107177830549 0.7595178648625843 0.9025683529783369 1.1672188057228077 0.9323986043860854 1.0 15.230362264545503 -7.43120301495884 3.142051127365557 1.0385395762586123 0.7430916063984518 0.7930953629526265 0.06613889044676925 0.10817928609431555 2.047236947915575 0.03125864588147434 0.01911615868463381 3.7050748415620536e-08 7.43120301495884 -0.2954479698601604 STS(ph)PASEKADPGAVK ddPTM_A459_Selumetinib_30min_R1 2 STSPASEKADPGAVK 15 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;Q9ULU4-2;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 S(0.036)T(0.036)S(0.928)PASEKADPGAVK;STS(0.998)PAS(0.001)EKADPGAVK 165.24 0.00041627 8252600.0 2315.05 2096.66 7374.4 6822.3 4538.0 3718.2 2772.0 3191.4 2189.29 2197.26 True False 2368.9861606968593 1851.1820724892102 6372.996984679656 5630.913375431825 4127.53870124897 3680.7982838554844 2562.9058082499973 3106.7537048718186 3715.065230584878 2479.2997241248436 0.9555061607297507 0.7466552165824365 2.570482674066053 2.27117089581392 1.664800209948771 1.4846120652696608 1.0337216526552333 1.2530770986022906 1.4984332851875106 1.0 11.275716974953323 -7.012741638116146 4.029030455075319 1.2180365667192838 1.6743904942439192 0.1382204429333327 0.5196295130372248 0.5025885306509291 18.667282654290226 0.22228506679092525 0.1807998316314271 9.710874956096507e-08 7.012741638116146 0.4563539275246353 STS(ph)PIIGSPPVR ddPTM_A459_Selumetinib_30min_R1 3 STSPIIGSPPVR 12 0 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 S(0.073)T(0.073)S(0.853)PIIGSPPVR;S(0.333)T(0.053)S(0.614)PIIGSPPVR;S(0.184)T(0.184)S(0.631)PIIGSPPVR 176.87 0.00010359 126917000.0 12058.0 16959.2 12924.5 13593.3 14477.3 13505.4 15576.699999999999 13611.900000000001 7705.299999999999 12941.099999999999 True False 12338.92793921631 14973.608979881828 11169.423889196714 11219.485332843382 13167.830771174911 13369.547937922085 14401.736978126883 13250.868194317462 13075.331327154303 14602.216241988664 0.8450037812572402 1.0254339979451355 0.7649129217165708 0.7683412673058325 0.9017693309670912 0.915583478313241 0.9862706276540883 0.9074559624870229 0.8954347141878501 1.0 13.833899729385937 -6.620852354323298 3.48586475686919 0.9382929087064044 0.8554622827641021 0.24312817768770267 0.073869477000298 0.4082838011679195 9.736715341051298 0.02688142866602898 0.02694440392389168 2.394129542469305e-07 6.620852354323298 -0.08283062594230228 STS(ph)PIIGSPPVR ddPTM_A459_Selumetinib_30min_R2 3 STSPIIGSPPVR 12 0 Q86TB9-4;Q86TB9;Q86TB9-2 Q86TB9-4 PATL1 Protein PAT1 homolog 1 1 S(0.02)T(0.07)S(0.91)PIIGSPPVR;S(0.211)T(0.061)S(0.728)PIIGSPPVR;S(0.191)T(0.065)S(0.744)PIIGSPPVR 209.67 6.8264e-06 153589000.0 324216.0 240597.0 328690.0 326569.0 328275.0 230385.0 262800.0 291359.0 268441.0 258505.0 True False 306197.3726594805 259050.01625871158 307542.44325061387 282089.73883705295 287034.1596842643 262118.44252319637 275020.720728321 292206.80645292124 322136.70086822327 251041.28897334886 1.2197092116268855 1.0319020322040051 1.225067177229413 1.1236786585612228 1.143374306505957 1.0441248274144397 1.0955198718626635 1.1639790715221456 1.283202066821853 1.0 17.9375651394028 -2.9054918052348495 11.552371510128598 1.1338699337929334 1.1359793627479855 0.0 0.08770956826245556 0.0 0.0 0.019152980177024534 0.0 0.0012431060919712745 2.9054918052348495 0.0021094289550520617 STS(ph)PPPSPEVWADSR ddPTM_A459_Selumetinib_30min_R1 1 STSPPPSPEVWADSR 15 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;E5RFK4;E5RJ61;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 ST(0.001)S(0.998)PPPSPEVWADSR 162.88 0.00010802 53273000.0 2158.5 2458.2 2547.0 2819.4 2599.4 2401.7 2020.0 2090.1 1331.2 2046.4 True False 2208.7888502901324 2170.3928012138235 2201.1313896695433 2327.0447166926815 2364.284728961343 2377.541078569123 1867.6297736886702 2034.6637583983804 2258.94917299882 2309.0753736240067 0.9565685362723875 0.9399402141678355 0.9532522908574226 1.0077820513240643 1.0239097241986896 1.029650701630264 0.8088214854405102 0.881159524561146 0.9782916568260327 1.0 11.173099551485144 -7.232124084637302 24.99213968702796 0.9071647350528448 0.9844633985684793 0.25186783573049354 0.05648126951856227 913.8639856018874 779096.9334239544 0.022312791212672895 0.0172809590333067 5.8597071971464805e-08 7.232124084637302 0.07729866351563452 STS(ph)PPPSPEVWADSR ddPTM_A459_Selumetinib_30min_R2 3 STSPPPSPEVWADSR 15 0 Q08495;Q08495-2;E5RGQ0;Q08495-3;E5RFK4;E5RJ61;E5RGQ7;E5RJC0 Q08495 DMTN Dematin 1 S(0.186)T(0.186)S(0.609)PPPS(0.019)PEVWADSR;S(0.001)T(0.001)S(0.999)PPPSPEVWADSR;ST(0.008)S(0.991)PPPSPEVWADSR 199.38 2.224e-05 121665100.0 157672.6 112680.8 146142.6 145529.5 155584.4 110530.8 102286.7 108902.5 79942.8 107737.3 True False 148909.78810542746 121323.05503412177 136739.9442240319 125708.13104761005 136038.49672981637 125755.41440129728 107043.23422725101 109219.3882452207 95933.59378846108 104626.64421387759 1.4232492041035585 1.159580869153305 1.3069323330729061 1.2014925260399036 1.300228041833462 1.2019444506337058 1.0230972715557372 1.0438965051956999 0.916913607516206 1.0 16.67489076942814 -7.235418834724303 2.073857640583502 0.9846306866035043 1.2708067869766315 0.7786952780798458 0.07148317407629477 0.14959978315179595 1.2580321574632016 0.033181249738258596 0.02172739851667822 5.815421065305443e-08 7.235418834724303 0.28617610037312724 STS(ph)PSAAGGQQK ddPTM_A459_Selumetinib_30min_R1 2 STSPSAAGGQQK 12 0 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 S(0.044)T(0.078)S(0.877)PSAAGGQQK;S(0.038)T(0.065)S(0.898)PSAAGGQQK 195.77 0.00015225 18915600.0 8386.7 15744.4 9614.5 8590.1 10614.8 13018.2 9378.3 11009.099999999999 10196.4 9705.2 True False 8582.09379232256 13901.038328627019 8308.903708668166 7090.000291147693 9654.693214195151 12887.24872757988 8670.887280487355 10717.102905403382 17302.546084408936 10950.956956653486 0.7836843689818657 1.2693902810184226 0.7587376830679546 0.6474320298410098 0.881630094284065 1.176814846281535 0.791792654724953 0.9786453318942121 1.5800031132344472 1.0 13.418769325749816 -8.067291809545162 9.611417097536345 1.288177718839029 0.9083103016836709 0.32341949343769094 0.22157191307496327 0.6042729875153987 82.99770600759427 0.1466233857252244 0.05538762641918348 8.564621809457682e-09 8.067291809545162 -0.3798674171553582 STS(ph)PSAAGGQQK ddPTM_A459_Selumetinib_30min_R2 2 STSPSAAGGQQK 12 0 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 S(0.294)T(0.07)S(0.631)PS(0.005)AAGGQQK;ST(0.002)S(0.994)PS(0.003)AAGGQQK 127.78 0.0025448 11818200.0 69608.0 41519.0 53947.0 61120.0 52224.0 56531.0 122288.0 216680.0 95810.0 129833.0 True False 65739.46602290186 44703.37379537341 50476.10875305251 52795.3505621191 45663.15423151634 64317.63211267577 127974.63430907486 217310.50292669502 114974.6771550714 126084.38394335393 0.5213926099875834 0.35455123304926756 0.40033592721307953 0.4187302892786352 0.3621634400976371 0.5101157661330353 1.0149919467153852 1.723532257764184 0.9118867345755222 1.0 16.944030077600246 -7.317966464886471 3.3179709725465494 1.255806970131054 0.41234374603116397 0.7511860678654566 0.20850906855542828 0.10876317029765512 2.400701964298734 0.08776897545548513 0.05791173317393137 4.8087647907282715e-08 7.317966464886471 -0.8434632240998899 STS(ph)PTFNK ddPTM_A459_Selumetinib_30min_R1 4 STSPTFNK 8 0 Q9BX63 Q9BX63 BRIP1 Fanconi anemia group J protein 1 S(0.002)T(0.075)S(0.916)PT(0.007)FNK;STS(0.994)PT(0.005)FNK;S(0.04)T(0.073)S(0.886)PT(0.001)FNK;S(0.007)T(0.007)S(0.986)PT(0.001)FNK 140.11 0.002362 90327000.0 37555.1 42862.399999999994 45244.0 48604.4 41435.2 37948.1 39477.3 36294.8 20791.2 31797.0 True False 38430.060760496126 37844.05028181082 39100.1133075025 40116.553957585966 37687.39347597871 37566.37656811799 36499.49547764343 35332.14400187431 35281.14787083314 35878.45467900825 1.0711180596911485 1.0547848456793374 1.089793684185043 1.1181237964816064 1.050418525913515 1.0470455571236545 1.0173095749020242 0.9847732941114217 0.9833519360429817 1.0 15.130830132823833 -7.16655043221548 1.368568959824986 0.9873960581696792 1.0803890166556802 0.8291489693177726 0.01766943078901497 0.18024571716628413 0.6677374798426141 0.011117356313499534 0.007040709598639652 6.81474434275878e-08 7.16655043221548 0.09299295848600098 STS(ph)PTFNK ddPTM_A459_Selumetinib_30min_R2 2 STSPTFNK 8 0 Q9BX63 Q9BX63 BRIP1 Fanconi anemia group J protein 1 S(0.007)T(0.007)S(0.98)PT(0.007)FNK;S(0.064)T(0.064)S(0.871)PT(0.001)FNK 137.05 0.0025561 77934000.0 723550.0 737140.0 813990.0 873200.0 868190.0 666400.0 670670.0 651550.0 593800.0 748120.0 True False 683337.9876001406 793676.2677213227 761618.7696053034 754268.6536459802 759120.2104829233 758190.5510231053 701857.4839073933 653445.9026300902 712576.5921582431 726519.8317508055 0.9405634336964994 1.092435791888406 1.0483110526658503 1.0381941699076598 1.0448719736301701 1.0435923671842213 0.9660541298866135 0.8994192230862882 0.9808081775841393 1.0 19.470642653957746 -7.3135895177602315 4.86857787214799 0.9516236550471908 1.0386419039033181 0.400201950773864 0.04320831608545352 0.18423386802686276 9.701771275097796 0.017629596856428276 0.011868979767691572 4.857473972665142e-08 7.3135895177602315 0.0870182488561273 STS(ph)PVTDPSIPIR ddPTM_A459_Selumetinib_30min_R1 2 STSPVTDPSIPIR 13 0 A0A087WU18;Q99607 A0A087WU18 ELF4 ETS-related transcription factor Elf-4 1 S(0.002)T(0.004)S(0.98)PVT(0.015)DPSIPIR;STS(0.618)PVT(0.382)DPSIPIR 234.87 9.497899999999999e-14 71280000.0 9424.599999999999 10393.0 10972.4 11867.0 11290.8 9897.5 11260.900000000001 9869.3 4695.6 8784.7 True False 9644.174842920727 9176.182728425385 9482.40834707896 9794.651221178994 10269.549133552651 9797.94013621098 10411.481246797395 9607.534103995562 7968.090246945063 9912.301815224202 0.9729500798803703 0.9257368166828598 0.9566303088668089 0.9881308503071901 1.0360408031341173 0.9884626516479175 1.0503595875991698 0.9692535884288198 0.8038587197483187 1.0 13.275004400782459 -8.023575270296638 24.709868912972 0.896804927555783 0.9881981422457179 0.2743732963846073 0.055291689435696866 797.7746020682924 836162.9112716018 0.036049765406978684 0.013819778266870579 9.471630115241436e-09 8.023575270296638 0.09139321468993489 STS(ph)PVTDPSIPIR ddPTM_A459_Selumetinib_30min_R2 4 STSPVTDPSIPIR 13 0 A0A087WU18;Q99607 A0A087WU18 ELF4 ETS-related transcription factor Elf-4 1 S(0.205)T(0.288)S(0.475)PVT(0.032)DPSIPIR;S(0.176)T(0.283)S(0.44)PVT(0.102)DPSIPIR;S(0.001)T(0.007)S(0.636)PVT(0.355)DPSIPIR;S(0.002)T(0.088)S(0.873)PVT(0.037)DPSIPIR 211.77 5.39e-06 54968100.0 180424.0 167149.0 197008.0 193124.0 192563.0 149678.0 146349.0 159306.0 140103.0 167692.0 True False 170396.75637449764 179968.79083125453 184332.71976609196 166820.17804251777 168371.51440493806 170294.78585839766 153154.51848504212 159769.55408547202 168127.5148048945 162850.2962438592 1.0463398612388033 1.1051179824798192 1.131915163912653 1.0243774920293292 1.0339036421082781 1.0457137001666288 0.940462019520688 0.9810823668765457 1.0324053359604146 1.0 17.313186818605125 -6.346560349748964 1.1974124735132934 0.9919418736883027 1.0924404746953058 0.5404053075787951 0.035702891710012084 0.3544747948737618 1.0505793089135844 0.01567805649248377 0.02105899269316241 4.5023541203335755e-07 6.346560349748964 0.10049860100700314 STS(ph)QELAK ddPTM_A459_Selumetinib_30min_R2 2 STSQELAK 8 0 E7EV90;Q5BKX6-2;Q5BKX6;Q5BKX6-3 E7EV90 SLC45A4 Solute carrier family 45 member 4 1 S(0.125)T(0.019)S(0.856)QELAK;S(0.224)T(0.005)S(0.771)QELAK 108.31 0.012929 10774600.0 178161.0 58546.0 116100.0 159274.0 91767.0 78828.0 267750.0 192589.0 125691.0 113952.0 True False 168259.52485499115 63036.289944939206 108630.25240012228 137580.60643702492 80238.40905261114 89685.8414706623 280200.9055365596 193149.4021051746 150832.71209996962 110661.90967714778 1.5204827509834449 0.5696295150593855 0.9816408619465109 1.2432516919183076 0.7250770322571142 0.8104490671841611 2.532044732953153 1.7454009484264386 1.363004782223791 1.0 16.7557991999322 -7.215604956158396 24.999876066594553 1.7222307238626509 0.9577812790223745 0.36465437878756846 0.4395693858006806 409.97593354455165 223617.0063440605 0.16313301092334231 0.12636188130077858 6.086884259572884e-08 7.215604956158396 -0.7644494448402763 STS(ph)QSIVSLLTGTAGEDEK ddPTM_A459_Selumetinib_30min_R1 2 STSQSIVSLLTGTAGEDEK 19 0 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 1 S(0.106)T(0.106)S(0.774)QS(0.015)IVSLLTGTAGEDEK;S(0.107)T(0.019)S(0.853)QS(0.021)IVSLLTGTAGEDEK 195.25 3.3714e-15 24978000.0 3003.7 3514.4 3584.8999999999996 3892.5 2784.3 3111.3 3077.9 3159.8 1619.1799999999998 2523.2 True False 3073.68036581722 3102.932414199767 3098.0902704461514 3212.747946274479 2532.4605566080922 3080.003146834373 2845.7315249684934 3075.9918395230857 2747.630199771808 2847.0772980492998 1.0795914701449023 1.0898658832781845 1.088165141342961 1.128437204172757 0.889494836807989 1.0818122672484742 0.9995273141752321 1.0804033461369766 0.965070460733318 1.0 11.475265947394016 STS(ph)SHGTDEMESSSYR ddPTM_A459_Selumetinib_30min_R1 1 STSSHGTDEMESSSYR 16 0 A0A0D9SGE8;Q5JRC6;Q8IWS0-2;Q8IWS0-3;Q8IWS0-4;Q8IWS0-5;Q8IWS0 A0A0D9SGE8;Q8IWS0-5 PHF6 PHD finger protein 6 1 ST(0.004)S(0.498)S(0.498)HGTDEMESSSYR 222.75 4.8032e-11 6624100.0 1506.8 1736.0 1648.5 1572.0 2247.8 1671.4 2011.2 1777.3 328.25 1075.8 True False 1541.9055082775867 1532.7483129554946 1424.642754562326 1297.4797100946641 2044.4868868813219 1654.5872335097781 1859.4935647735915 1730.160230515976 557.0162755685567 1213.88940917939 1.2702190962518911 1.2626754145516919 1.1736182421472883 1.068861545609647 1.6842447684451172 1.3630461069994073 1.5318475890078331 1.425303011487343 0.4588690463533323 1.0 10.245421276193037 -11.271496022357718 9.952665368782773 0.9991457401645014 1.2713426806120287 0.049490722205705495 0.31324155368390416 0.005897926990889707 0.00014896861159108707 0.30126833220481647 0.07286689905401612 5.35185055433742e-12 11.271496022357718 0.2721969404475273 STS(ph)SHGTDEMESSSYR ddPTM_A459_Selumetinib_30min_R2 1 STSSHGTDEMESSSYR 16 0 A0A0D9SGE8;Q5JRC6;Q8IWS0-2;Q8IWS0-3;Q8IWS0-4;Q8IWS0-5;Q8IWS0 A0A0D9SGE8;Q8IWS0-5 PHF6 PHD finger protein 6 1 ST(0.005)S(0.926)S(0.069)HGTDEMESSSYR 293.38 6.814299999999997e-75 3003400.0 12812.0 12462.0 18861.0 21282.0 25335.0 17767.0 14241.0 14727.0 14789.0 18164.0 True False 12099.960330499627 13417.795328354321 17647.50379430411 18383.354886502257 22152.190802226294 20214.242977232145 14903.234718006146 14769.853131813903 17747.213239185363 17639.558124260297 0.6859559771997991 0.7606650480603798 1.0004504460932548 1.04216640558694 1.2558245873381384 1.145960847478985 0.844875739688128 0.8373142358651496 1.0061030505507393 1.0 14.106526800993468 -5.211079839888836 3.2012176613942445 1.0209398042426236 0.698856127783172 0.5059126050955558 0.1170522650962004 0.23558603879051793 4.789961960757361 0.0359668259911818 0.11261517051896741 6.150637901338987e-06 5.211079839888836 -0.3220836764594517 STS(ph)TPNVHMVSTTLPVDSR ddPTM_A459_Selumetinib_30min_R1 4 STSTPNVHMVSTTLPVDSR 19 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 S(0.102)T(0.102)S(0.605)T(0.19)PNVHMVSTTLPVDSR;S(0.084)T(0.084)S(0.808)T(0.025)PNVHMVSTTLPVDSR;S(0.076)T(0.076)S(0.424)T(0.424)PNVHMVSTTLPVDSR;S(0.135)T(0.135)S(0.566)T(0.164)PNVHMVSTTLPVDSR 259.34 3.0239e-47 155958300.0 6761.699999999999 7925.66 8748.65 8896.2 9080.300000000001 7354.29 8428.3 7256.82 3190.38 5647.86 True False 6919.234454022134 6997.720042660626 7560.631382894563 7342.64567235633 8258.988468257168 7280.312519761052 7792.546545336738 7064.345560126566 5413.841843864167 6372.817845815131 1.0857417584225824 1.098057438948432 1.1863874922863895 1.1521819468256198 1.2959712121193985 1.1424008493419986 1.2227787979934037 1.1085120791214116 0.8495208830453707 1.0 12.637715709464418 -8.107637866401323 4.845355383466901 0.9290011350145636 1.1700336793426187 0.6770131220105271 0.06639335628054487 0.12859620689592208 4.5763465135064685 0.0478895969204117 0.017248452575734062 7.804806379156075e-09 8.107637866401323 0.2410325443280551 STS(ph)TPNVHMVSTTLPVDSR ddPTM_A459_Selumetinib_30min_R2 4 STSTPNVHMVSTTLPVDSR 19 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 S(0.131)T(0.131)S(0.52)T(0.218)PNVHMVSTTLPVDSR;S(0.123)T(0.123)S(0.593)T(0.162)PNVHMVSTTLPVDSR;S(0.128)T(0.128)S(0.614)T(0.128)PNVHMVSTTLPVDSR;S(0.11)T(0.11)S(0.644)T(0.136)PNVHMVSTTLPVDSR 118.08 0.00030049 31531900.0 58113.0 56335.8 60667.4 82320.0 73098.0 53036.0 49270.2 57959.0 45434.2 66137.0 True False 54883.312104770936 60656.57471185237 56764.125533670805 71107.87399007924 63914.77573558871 60341.227587126894 51561.36192704912 58127.65109437102 54522.309537615525 64227.45296543735 0.8545148463898332 0.9444026177481059 0.8837984835583815 1.1071258582890473 0.995131719920189 0.9394927682964208 0.8027931911731854 0.9050281213183277 0.848894156941823 1.0 15.970902464924555 -7.018384231337227 23.836304360593978 0.8798185936648397 0.96124360934647 0.13783146356134313 0.07878499481834836 722.0289194646521 936153.7032230125 0.03015118087109391 0.023836262875097887 9.585522008264499e-08 7.018384231337227 0.0814250156816303 STS(ph)TPTSPGPR ddPTM_A459_Selumetinib_30min_R1 3 STSTPTSPGPR 11 0 H3BUF6;H3BRB0;A0A0C4DGL7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 S(0.001)T(0.018)S(0.976)T(0.005)PTSPGPR;S(0.016)T(0.07)S(0.848)T(0.033)PT(0.033)SPGPR;STS(0.896)T(0.08)PT(0.023)SPGPR 147.28 0.00066928 45027000.0 10453.7 11531.8 11825.4 11478.8 13684.3 8836.2 11431.4 11061.5 5167.9 8913.8 True False 10697.250870640706 10181.65149501163 10219.57563227256 9474.243063762493 12446.557481159387 8747.315850627681 10569.120294527065 10768.113087184196 8769.548851517882 10057.973057764682 1.063559308541049 1.012296556824784 1.0160671114925208 0.9419634561904544 1.237481688375645 0.8696897277801731 1.0508201039937943 1.0706046859880272 0.8719002130103991 1.0 13.296051973544946 STS(ph)TPTSPGPR ddPTM_A459_Selumetinib_30min_R2 4 STSTPTSPGPR 11 0 H3BUF6;H3BRB0;A0A0C4DGL7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 S(0.001)T(0.024)S(0.459)T(0.134)PT(0.382)SPGPR;S(0.074)T(0.002)S(0.448)T(0.115)PT(0.361)SPGPR;S(0.008)T(0.001)S(0.982)T(0.008)PT(0.001)SPGPR;S(0.001)TS(0.494)T(0.494)PT(0.011)SPGPR 169.21 0.00043473 101582000.0 220826.0 190850.0 294184.0 327654.0 354555.0 266293.0 169975.0 216122.0 190792.0 294172.0 True False 208553.37495651806 205487.58132052846 275256.52172332146 283026.9599653231 310012.6311380838 302972.44358282664 177879.17429907282 216750.8792390766 228955.73117389 285678.4900093529 0.7300282739162132 0.7192966516793089 0.9635185404204207 0.9907184820112183 1.085180165744835 1.060536421810783 0.6226551193730028 0.7587231339397668 0.8014454681778602 1.0 18.12403288794215 -10.247970969518029 9.238074401518288 0.9999970473883945 0.8646157437117515 0.07230227439765047 0.15023226616361604 0.0 0.0 0.16252806161445724 0.03941884500960603 5.6497473937414036e-11 10.247970969518029 -0.13538130367664292 STS(ph)VPENPK ddPTM_A459_Selumetinib_30min_R1 2 STSVPENPK 9 0 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;D6RDA9;Q3MSN4;P04150-12;P04150-13;P04150-11 P04150-3 NR3C1 Glucocorticoid receptor 1 STS(1)VPENPK;S(0.027)T(0.065)S(0.908)VPENPK 187.16 0.0020808000000000003 18587100.0 15544.5 17735.8 18659.6 20807.4 18177.9 16577.0 17209.4 16837.3 9448.1 14528.1 True False 15906.656605668262 15659.284290850272 16125.728809846014 17173.77819327208 16533.712154568904 16410.25043071174 15911.28110263258 16390.7201087417 16032.735638078542 16392.923150677732 0.9703368007926416 0.9552466114137106 0.9837006287179068 1.047633667004781 1.0085884013849813 1.0010569975760115 0.9706189040466989 0.9998656101833834 0.978027865482655 1.0 14.000785515192547 -5.521142261016847 24.99917802756292 1.0011091740088223 0.9644621771723637 0.3779597590873559 0.0195066346446749 69.13884614379458 995353.0082912665 0.005658553764306643 0.010000424934803383 3.0120192211688343e-06 5.521142261016847 -0.036646996836458556 STS(ph)VPENPK ddPTM_A459_Selumetinib_30min_R2 3 STSVPENPK 9 0 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;D6RDA9;Q3MSN4;P04150-12;P04150-13;P04150-11 P04150-3 NR3C1 Glucocorticoid receptor 1 ST(0.004)S(0.995)VPENPK;ST(0.005)S(0.995)VPENPK;ST(0.017)S(0.982)VPENPK 157.75 0.00086245 31898700.0 292242.0 196482.0 261979.0 296611.0 341121.0 121571.0 198045.0 260777.0 153765.0 152679.0 True False 276000.35957741714 211551.53761079392 245123.5563611679 256212.0701174858 298266.33031956735 138316.30173833997 207254.48491872242 261535.8178960439 184522.2965530691 148270.7605623177 1.861461818437325 1.4267920175797542 1.6532157482131704 1.7280013210008505 2.0116328343389527 0.932862967814926 1.3978108976625505 1.763906901833968 1.2444955151863202 1.0 17.177874596498846 -6.752983952735368 24.999824563041486 1.323684144260771 1.7139621798717743 0.44565361353296906 0.25686432468044407 217.62838666445475 643452.3821907457 0.08754869143860695 0.08618851330613347 1.766103077328906e-07 6.752983952735368 0.3902780356110034 STS(ph)YGYSR ddPTM_A459_Selumetinib_30min_R1 2 STSYGYSR 8 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 ST(0.002)S(0.998)YGYSR;ST(0.047)S(0.946)YGYS(0.007)R 122.96 0.0061456 38842300.0 6065.6 7967.4 7464.4 7900.799999999999 7841.599999999999 6625.6 6637.4 6800.4 3759.2 6142.2 True False 6206.916678396956 7034.573104056233 6450.775479014271 6521.073596384171 7132.328664546927 6558.952479563471 6136.735574198604 6620.031301187667 6379.087838895106 6930.6112000944895 0.8955799855447573 1.015000394764653 0.9307657424104707 0.940908876304483 1.02910529225037 0.9463743225812534 0.8854537351792202 0.955187228089986 0.920422117865757 1.0 12.758766871723415 -9.426890122405982 12.974357668648935 1.0000001892721233 0.9487996666679976 0.11783086796027609 0.0434925590226127 0.0 0.0 0.04187303721973474 0.010155703254258002 3.74205251164388e-10 9.426890122405982 -0.051200522604125664 STS(ph)YGYSR ddPTM_A459_Selumetinib_30min_R2 3 STSYGYSR 8 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 ST(0.001)S(0.998)YGYSR;ST(0.001)S(0.999)YGYSR;ST(0.004)S(0.95)Y(0.001)GYS(0.045)R 154.01 0.00077829 720350000.0 2279360.0 1839870.0 2409730.0 2271560.0 2770810.0 2024190.0 1886640.0 2092260.0 1952920.0 1950280.0 True False 2152682.2962010344 1980982.1128855124 2254690.595315647 1962169.6093404314 2422716.076444315 2303003.7987326793 1974372.498306239 2098348.13020771 2343558.5691439565 1893970.3489640164 1.136597675554177 1.0459414604716968 1.190457177193371 1.0360086209447361 1.2791731812324925 1.2159661316727584 1.0424516410123326 1.1079097047931539 1.2373787004774708 1.0 20.852982314207864 -4.398020354736292 20.867008035377346 1.132951954701491 2.6082529564466963 0.0 0.09270721434838722 15836.219515210989 4173018.287793751 0.021851925071038617 645802.1760635066 3.999260053849151e-05 4.398020354736292 1.4753010017452053 STSAPQMS(ph)PGSSDNQSS(ph)SPQPAQQK ddPTM_A459_Selumetinib_30min_R1 1 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 2 S(0.002)T(0.002)S(0.003)APQMS(0.751)PGS(0.138)S(0.171)DNQS(0.039)S(0.513)S(0.38)PQPAQQK 66.454 0.0079904 10672000.0 2208.0 2708.7 2880.2 3173.7 3110.2 2515.7 2220.4 2579.6 1132.1 2137.1 True False 2259.4421039798976 2391.564144759533 2489.084659806134 2619.4728727273773 2828.88295915041 2490.3943420728438 2052.9134403457033 2511.1806282782945 1921.0910146874733 2411.41760211682 0.9369766986839968 0.9917668937392433 1.0322080495809334 1.0862792369218504 1.1731203076012737 1.032751166735573 0.8513305362553503 1.041371111363664 0.7966645897421822 1.0 11.23566579886789 -7.131032259953236 7.299332645525197 0.9262595330924631 1.0485692548142953 0.3171208087180284 0.086034462685848 0.3315759901961366 18.15585455240931 0.03335727801993719 0.02582004234680733 7.395503382666354e-08 7.131032259953236 0.12230972172183219 STSAPQMS(ph)PGSSDNQSS(ph)SPQPAQQK ddPTM_A459_Selumetinib_30min_R2 1 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 2 STSAPQMS(0.892)PGS(0.051)S(0.012)DNQS(0.065)S(0.533)S(0.445)PQPAQQK 72.949 0.0023562 15960000.0 64099.0 55677.0 72725.0 81260.0 69190.0 59620.0 59015.0 60664.0 47639.0 73789.0 True False 60536.6341886275 59947.24687022821 68045.95267699318 70192.24781868124 60497.73363355199 67832.11382352564 61759.31443600404 60840.522196534155 57168.13114487471 71658.51984315367 0.8447932544675807 0.8365683103899003 0.9495863552014795 0.9795380643127738 0.8442503943141662 0.9466022180195282 0.8618558486999587 0.8490340343297912 0.7977855427380365 1.0 16.128850623530752 -9.518852820643492 12.249657041302232 1.0000001987443372 0.8822787439025616 0.2921788434693676 0.05632882627618529 0.0 0.0 0.05736119445114853 0.013912133149039947 3.027939401688175e-10 9.518852820643492 -0.11772145484177565 STSAPQMS(ph)PGSSDNQSSS(ph)PQPAQQK ddPTM_A459_Selumetinib_30min_R2 2 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 2 STS(0.001)APQMS(0.952)PGS(0.014)S(0.023)DNQS(0.01)S(0.362)S(0.638)PQPAQQK;S(0.002)T(0.002)S(0.002)APQMS(0.887)PGS(0.034)S(0.054)DNQS(0.019)S(0.331)S(0.669)PQPAQQK 112.05 5.8981e-07 19685600.0 148737.0 150544.0 158553.0 171501.0 178317.0 134896.0 135529.0 142385.0 133074.0 160296.0 True False 140470.7929813864 162090.24072474518 148351.87259945352 148142.26794427328 155915.22428579378 153476.69953603356 141831.36704561883 142799.31677689447 159692.51839822534 155667.83798097508 0.9023751778357325 1.0412570947670965 0.9530027173473323 0.9516562307647548 1.0015891934263836 0.9859242700781307 0.9111154165509302 0.9173334622553612 1.0258542835145057 1.0 17.24811137917299 STSAPQMS(ph)PGSSDNQSSSPQPAQQK ddPTM_A459_Selumetinib_30min_R1 2 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 STS(0.001)APQMS(0.837)PGS(0.07)S(0.091)DNQSSSPQPAQQK;STSAPQMS(0.957)PGS(0.041)S(0.003)DNQSSSPQPAQQK 135.47 2.9417e-08 60538300.0 10143.17 11135.84 10362.61 12151.2 14547.5 10171.980000000001 11499.8 10662.22 4882.8099999999995 7414.18 True False 10379.486125826896 9832.050675888431 8955.424479742253 10029.221026273717 13231.681193569737 10069.65911661888 10632.360827457904 10379.423289828419 8285.77194366765 8365.862223228902 1.2406953221159807 1.1752584985906733 1.0704723841705586 1.1988269420008237 1.5816279112068399 1.203660644644513 1.2709222963218034 1.2406878111151058 0.9904265361508262 1.0 13.030298523200912 -8.25598327688806 7.758919638226221 0.9942488998345197 1.2484294476066302 0.39988057012079425 0.1237616441201952 0.12486353534864998 72.49726372279068 0.10216693743756945 0.03361311476344102 5.546470700021428e-09 8.25598327688806 0.2541805477721105 STSAPQMS(ph)PGSSDNQSSSPQPAQQK ddPTM_A459_Selumetinib_30min_R2 6 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 S(0.001)T(0.001)S(0.004)APQMS(0.471)PGS(0.242)S(0.242)DNQS(0.027)S(0.008)S(0.003)PQPAQQK;STSAPQMS(0.908)PGS(0.092)SDNQSSSPQPAQQK;S(0.003)T(0.003)S(0.008)APQMS(0.926)PGS(0.026)S(0.026)DNQS(0.003)S(0.004)S(0.001)PQPAQQK;STSAPQMS(0.959)PGS(0.039)S(0.001)DNQSSSPQPAQQK;S(0.002)T(0.002)S(0.002)APQMS(0.976)PGS(0.02)SDNQSSSPQPAQQK;S(0.002)T(0.002)S(0.002)APQMS(0.989)PGS(0.004)SDNQSSSPQPAQQK 189.85 2.3628e-26 179301700.0 645028.0 618586.0 686563.0 726383.0 733218.0 511822.5 564169.9 558419.5 502420.0 639773.5 True False 609179.9260116696 666029.5571325149 642390.2840532744 627448.3823194319 641104.5997879127 582321.4035129392 590404.918231448 560044.4082936747 602918.038787714 621301.5767238169 0.9804899083371621 1.071990772411287 1.0339427873990925 1.0098934331183056 1.031873447301581 0.9372604630807089 0.9502710766399629 0.9014050974195862 0.9704112485388479 1.0 19.24493418995693 -6.7596311526581925 24.9979920339373 0.9456074819513068 1.0277999012763341 0.5678814975018642 0.03191408247140057 31.474834392855584 435127.6978159163 0.01036617407539118 0.009861103432028829 1.7392773740760135e-07 6.7596311526581925 0.0821924193250273 STSAPQMSPGS(ph)SDNQSSSPQPAQQK ddPTM_A459_Selumetinib_30min_R1 3 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 STSAPQMS(0.369)PGS(0.62)S(0.01)DNQSSSPQPAQQK;STSAPQMS(0.221)PGS(0.389)S(0.389)DNQSSSPQPAQQK;S(0.001)T(0.001)S(0.002)APQMS(0.084)PGS(0.649)S(0.141)DNQS(0.041)S(0.041)S(0.041)PQPAQQK 140.71 3.8728e-08 32842600.0 10093.900000000001 12148.4 11452.0 13351.2 15430.5 12174.1 13392.7 11913.4 5996.299999999999 8861.699999999999 True False 10329.068230689634 10726.059680362067 9896.881301333182 11019.66355306354 14034.81399947605 12051.639607198385 12382.477856475365 11597.417931823002 10175.283147575738 9999.185515267714 1.0329909586054007 1.0726933372707699 0.9897687452864711 1.102056116094422 1.403595720676084 1.205262127479962 1.23834864725418 1.1598362600748784 1.0176111976359614 1.0 13.28759486945546 -6.005427088357707 24.95723060299751 1.1901391229130955 1.0375730797931977 0.23658354684061023 0.10885462778825684 310.82685188357317 1429396.022839223 0.03129192463747769 0.044912412429709794 9.875814221944036e-07 6.005427088357707 -0.15256604311989785 STSAPQMSPGS(ph)SDNQSSSPQPAQQK ddPTM_A459_Selumetinib_30min_R2 1 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 STSAPQMS(0.228)PGS(0.771)S(0.001)DNQSSSPQPAQQK 173.18 2.4961000000000003e-16 5997900.0 76136.0 81490.0 86104.0 90338.0 95468.0 72228.0 72372.0 71818.0 62126.0 85272.0 True False 71904.66591655638 87740.02096835115 80564.16238294693 78033.80855825765 83474.45634525134 82176.75137949699 75737.44140239735 72026.97848989014 74552.93594547514 82809.9757967365 0.8683092251234555 1.0595344356061138 0.972879917036782 0.9423237696602843 1.0080241606415374 0.9923532833919211 0.9145932078074841 0.8697862521622508 0.9002893096898265 1.0 16.33751695362151 -7.274393342013833 19.12673392870833 0.9103158034613339 0.9778652880006401 0.16515209443754708 0.05557393353554073 48.58532371274976 71732.21916974105 0.021993104095451174 0.015027580812435515 5.3162654515460934e-08 7.274393342013833 0.0675494845393062 STSAPQMSPGSSDNQSS(ph)SPQPAQQK ddPTM_A459_Selumetinib_30min_R1 1 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 STSAPQMSPGS(0.002)S(0.01)DNQS(0.334)S(0.521)S(0.133)PQPAQQK 111.38 1.0963e-07 49831000.0 3750.6 4484.8 4141.1 4475.6 6541.5 3569.0 4625.8 4042.1 1748.9 2724.1 True False 3837.9816826028123 3959.7175310730436 3578.76136543406 3694.020477417099 5949.822479995627 3533.0991003927256 4276.872181747052 3934.8903774087826 2967.755565397864 3073.7647699810173 1.2486256983895727 1.2882305014828763 1.16429253155119 1.2017902324516239 1.935679183424427 1.1494370470042654 1.391411673240521 1.2801533857885565 0.9655116079088225 1.0 11.585791046903834 -8.203045237390175 4.074742563725181 0.9778146382859259 1.3408608707164833 0.30231024437036436 0.21363808414314464 0.27443730518780324 8.975892344947171 0.1719855523466968 0.05614290233704055 6.265485981290188e-09 8.203045237390175 0.36304623243055745 STSAPQMSPGSSDNQSS(ph)SPQPAQQK ddPTM_A459_Selumetinib_30min_R2 1 STSAPQMSPGSSDNQSSSPQPAQQK 25 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 STSAPQMSPGSSDNQS(0.01)S(0.495)S(0.495)PQPAQQK 127.15 2.3825e-08 0.0 6532.3 7228.0 8661.2 8027.2 10367.0 7052.1 4865.6 5705.6 5232.2 7133.3 True False 6169.260916868774 7782.36435831689 8103.947821601544 6933.881512307631 9064.60477784409 8023.462762410017 5091.860041003497 5722.202351387072 6278.786199882735 6927.3430944608 0.8905666765374738 1.1234270126651842 1.1698493507679117 1.0009438565056867 1.3085254554653536 1.158230890689634 0.7350379462329532 0.8260313186974418 0.9063772523268466 1.0 12.758086413442486 -7.251159698383106 24.81361985039592 0.8523642373125774 1.1162443457389164 0.48942191244564537 0.12043970489957852 506.680834376302 1223053.9179887993 0.04658256517818578 0.0356694351545628 5.608417058935738e-08 7.251159698383106 0.263880108426339 STSFRGGMGS(ph)GGLATGIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R1 1 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.186)T(0.186)S(0.186)FRGGMGS(0.222)GGLAT(0.22)GIAGGLAGMGGIQNEK 49.709 0.031443 53026000.0 562.91 619.39 704.78 1097.8 657.92 507.84 484.33 471.07 306.64 368.42 True False 576.0247077678104 546.8715308534008 609.0747470794273 906.0898382582201 598.4112521652104 502.731590681827 447.7965981636797 458.5756933489905 520.3456839005094 415.71029571469734 1.385639744085475 1.315511154019432 1.465142319923287 2.179618468915841 1.439491055030066 1.2093315846736992 1.0771842862198515 1.103113630035547 1.251702662321415 1.0 8.699434668775256 -6.729995024815222 3.675301021896713 1.1244021034870173 1.582841709489229 0.4759327538809268 0.22878630714463524 0.22219903479586986 6.321376776867734 0.08711455040839118 0.08299922011033234 1.8621084684573735e-07 6.729995024815222 0.4584396060022118 STSFRGGMGSGGLAT(ph)GIAGGLAGMGGIQNEK ddPTM_A459_Selumetinib_30min_R1 1 STSFRGGMGSGGLATGIAGGLAGMGGIQNEK 31 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 S(0.033)T(0.15)S(0.15)FRGGMGS(0.034)GGLAT(0.634)GIAGGLAGMGGIQNEK 62.848 0.00134 319190000.0 656.43 547.15 872.79 1245.3 1099.7 827.78 716.72 624.39 376.87 558.66 True False 671.7235418095676 483.0894236368662 754.2699118922975 1027.8317321761358 1000.2323291678039 819.4532847641043 662.6572333654177 607.8291488954424 639.5208645042562 630.3694528092193 1.0656029393811124 0.7663591906048035 1.1965521307083016 1.630522747565955 1.5867398471012573 1.2999571618076344 1.0512204079882188 0.964242709075881 1.0145175367465127 1.0 9.300053814435067 -7.359030256007841 4.485504705693943 0.9959464385527552 1.2640164040834212 0.2213953298453203 0.2309671707467224 0.4292977504591172 14.64301616516406 0.11884538935949442 0.07837034464365508 4.374916253532072e-08 7.359030256007841 0.268069965530666 STSGPRPGCQPS(ph)SPCVPK ddPTM_A459_Selumetinib_30min_R2 1 STSGPRPGCQPSSPCVPK 18 1 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 STS(0.001)GPRPGCQPS(0.518)S(0.48)PCVPK 59.163 0.029639 12050000.0 28366.0 24831.0 27661.0 29454.0 33919.0 24157.0 24061.0 19178.0 19555.0 30745.0 True False 26789.531278094946 26735.457855750796 25881.32137501966 25442.31438901596 29657.79198029264 27484.407474587533 25179.88417596699 19233.804804911186 23466.546412351745 29857.311964896657 0.8972519465111759 0.895440885207073 0.8668336052973696 0.8521301053131835 0.9933175503260778 0.9205251801267658 0.8433406264291663 0.6441907706736774 0.7859564330486765 1.0 14.865796665936983 -7.524808703530919 24.95471616675964 0.777797296772074 0.9020035821929965 0.16165643112765893 0.08930987908024683 79.59202871860872 1029086.8160771431 0.040061219338109647 0.02333509620267474 2.986697899154421e-08 7.524808703530919 0.12420628542092249 STSGPRPGCQPSS(ph)PCVPK ddPTM_A459_Selumetinib_30min_R2 1 STSGPRPGCQPSSPCVPK 18 1 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 STSGPRPGCQPS(0.242)S(0.758)PCVPK 74.214 0.0090502 7289700.0 31225.0 28268.0 35321.0 45437.0 35233.0 30120.0 25303.0 29298.0 26857.0 39270.0 True False 29489.63950357876 30436.064704053944 33048.485314597056 39248.40221680308 30806.715552983613 34268.756597862994 26479.639636943317 29383.25232945501 32229.150447278476 38136.17306428657 0.7732721228705289 0.7980891174567393 0.8665915496787487 1.0291646765563396 0.8078082586066616 0.8985892879208348 0.6943444375581759 0.7704824571653619 0.845107095380269 1.0 15.218872457122892 -8.57613294112346 20.15635116015554 1.000000001348876 0.8320375887719257 0.2620868511225454 0.08510203931703517 5233.651252910564 1980899.6003950837 0.08770519872421587 0.02264538486851073 2.65379308967343e-09 8.57613294112346 -0.16796241257695022 STSLSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 STSLSSPR 8 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 ST(0.001)S(0.004)LS(0.035)S(0.96)PR 85.73100000000002 0.034863 10823000.0 5639.2 7271.0 7073.3 6949.8 7617.2 5804.6 6686.4 6277.7 3613.9 5219.7 True False 5770.582388026921 6419.707939803806 6112.784710855745 5736.147893903242 6928.2256049258895 5746.210994155119 6182.039464748473 6111.195003156553 6132.524351187229 5889.699339183555 0.9797753765860064 1.0899890758589592 1.0378772088055543 0.9739288142844998 1.1763292497518723 0.9756374074863511 1.049635831768187 1.0376072955879785 1.0412287619485403 1.0 12.523978273057356 -4.728403431095356 24.121035745416272 1.0436786418594524 0.9797746736354961 0.10133645523903678 0.055906458844834056 6925.4016858510295 5056093.129279224 0.013112525319073686 1.95844735603468 1.86894520619898e-05 4.728403431095356 -0.06390396822395628 STSLSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 STSLSSPR 8 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 STSLS(0.224)S(0.776)PR 91.265 0.027107 13297000.0 163300.0 155870.0 193930.0 184430.0 236370.0 140980.0 173370.0 168650.0 146080.0 188430.0 True False 154224.43974169457 167824.72779895572 181452.7549350191 159310.31584050442 206675.08742538898 160398.71531098013 181432.04852613749 169140.7435784895 175300.08181622857 182989.5363000639 0.8428046917873999 0.9171274554396317 0.9916018074250715 0.8705979536407449 1.1294366421393944 0.8765458318226479 0.9914886511796366 0.9243192097122683 0.9579787203175035 1.0 17.48140162917779 -4.860074932333781 2.498470208736644 0.9651349286067153 0.8265260043754963 0.23556177156261715 0.06947637157866049 0.6194307496178688 5.652452003667376 0.0170665223921373 0.17311008547454582 1.3801461163048743e-05 4.860074932333781 -0.13860892423121907 STSQGS(ph)INSPVYSR ddPTM_A459_Selumetinib_30min_R2 2 STSQGSINSPVYSR 14 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 STS(0.001)QGS(0.667)INS(0.332)PVYSR;ST(0.001)S(0.003)QGS(0.965)INS(0.031)PVYSR 92.265 0.015927 21015200.0 45058.0 34400.0 50248.0 47030.0 50865.0 29721.6 34407.0 32037.0 28157.4 31330.0 True False 42553.856741465184 37038.369386566286 47015.098385885816 40624.432868724805 44474.8839611305 33815.48061417814 36006.99367617709 32130.22236598913 33789.666783490306 30425.421494884085 1.3986283394174324 1.2173494258015174 1.5452570934404712 1.3352134784905327 1.4617672254305096 1.111421927872522 1.183450940268207 1.0560321200937743 1.1105734981903834 1.0 14.892989628827548 -6.772069557333455 24.84428347995191 1.1014948194742147 1.3873592555239738 0.7328325947251311 0.09026828669475921 104.90620837368456 245179.624178753 0.03073244854701999 0.02738167055551365 1.6901702094654336e-07 6.772069557333455 0.2858644360497591 STSQGSINS(ph)PVYSR ddPTM_A459_Selumetinib_30min_R2 2 STSQGSINSPVYSR 14 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 STSQGS(0.083)INS(0.917)PVYSR;STSQGS(0.066)INS(0.934)PVYSR 214.54 1.1089e-06 21197800.0 40756.0 32506.0 43738.0 41254.0 49424.0 31953.0 30345.3 31173.0 32386.0 32482.0 True False 38490.94467919475 34999.10567673615 40923.944698333726 35635.13403288058 43214.91526383392 36354.235709545734 31756.416578071203 31263.708269032024 38864.10494044609 31544.160261628625 1.220224103604255 1.1095272591329761 1.297354069942226 1.1296903685918802 1.369981476932895 1.1524870343043574 1.0067288624798414 0.991109226231717 1.2320538767906808 1.0 14.94508532480822 -7.004993641060103 24.87248894008764 1.0600000554113924 1.2219686021755558 0.4112820487850777 0.09462475446761548 207.60990075340638 1034073.5569153089 0.03287078862409703 0.02819414055153875 9.88567569157531e-08 7.004993641060103 0.1619685467641634 STSS(ph)PSLHSR ddPTM_A459_Selumetinib_30min_R2 1 STSSPSLHSR 10 0 Q9H1A4 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 S(0.025)T(0.025)S(0.217)S(0.732)PSLHSR 92.19 0.017843 968110.0 2856.3 3150.4 4509.1 5166.6 7518.7 3999.9 2701.3 2375.9 3134.5 6293.2 True False 2697.558280674844 3392.0255498673946 4218.989415136875 4462.900167117875 6574.1336879691735 4550.849917522981 2826.915802524405 2382.8134756485815 3761.4875852475852 6111.498964302731 0.44139061405905217 0.555023500728744 0.6903362726198589 0.7302464081538224 1.0756990594891191 0.7446372721495165 0.4625568651874805 0.3898901872628297 0.6154770878991286 1.0 12.577310557200487 -5.038932825877573 2.4372726327321432 0.6981686550042577 0.43831569766299494 0.16602972648597103 0.19862301012047173 0.7544836905220955 7.794999704119791 0.05872795110373922 0.3249143198103179 9.142546420785048e-06 5.038932825877573 -0.2598529573412628 STSS(ph)SSDTMSTFKPMVAPR ddPTM_A459_Selumetinib_30min_R1 1 STSSSSDTMSTFKPMVAPR 19 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 S(0.001)T(0.001)S(0.025)S(0.89)S(0.035)S(0.049)DTMSTFKPMVAPR 135.55 0.00010334 23458000.0 664.26 529.12 731.22 823.96 758.1 553.37 664.99 506.71 478.51 599.47 True False 679.7359655750399 467.1703844187856 631.9243403039513 680.0708536447837 689.5299888534256 547.8036002197596 614.8292689134796 493.27040477395485 811.996521012369 676.4178138322825 1.0049054765780905 0.6906535795856794 0.9342219074978956 1.0054005671314372 1.0193847275352719 0.8098598070860198 0.9089489607468059 0.7292392286053262 1.2004363344778841 1.0 9.401770844184181 -8.271561046147296 24.983363024169602 1.1002181597861616 0.8892104085196391 0.34393930840378795 0.11732263492234632 875.0144950808517 2159778.065757389 0.1068997980383246 0.028891460937256617 5.351049320224378e-09 8.271561046147296 -0.2110077512665225 STSS(ph)SSDTMSTFKPMVAPR ddPTM_A459_Selumetinib_30min_R2 2 STSSSSDTMSTFKPMVAPR 19 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 S(0.008)T(0.008)S(0.029)S(0.641)S(0.157)S(0.157)DT(0.001)MSTFKPMVAPR;S(0.042)T(0.042)S(0.317)S(0.564)S(0.017)S(0.017)DTMSTFKPMVAPR 114.27 0.00079376 18068500.0 40363.0 34082.0 37798.0 43287.0 43998.0 31825.0 34913.0 35464.0 33360.8 35089.0 True False 38119.78604589109 36695.97980909745 35366.117831350755 37391.235925759946 38470.5778928894 36208.60487141402 36536.523678797035 35567.19436861873 40033.892178633796 34075.88939782918 1.1186732531277532 1.0768898613526778 1.0378633824772237 1.0972930299551322 1.1289676828021453 1.0625872284266982 1.072210419873138 1.0437642273508656 1.1748451144222862 1.0 15.056463692136566 -10.570884977980835 7.737343251976882 0.9999999981596355 1.0870252479882836 0.31462146088480847 0.03973203653976644 2.534429571940999e-09 2.8854826209574946e-10 0.03745675959824624 0.00908459819488316 2.686055747917849e-11 10.570884977980835 0.08702524982864812 STSS(ph)TSSGSNSNALVPVSWK ddPTM_A459_Selumetinib_30min_R2 1 STSSTSSGSNSNALVPVSWK 20 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 S(0.056)T(0.056)S(0.242)S(0.481)T(0.109)S(0.006)SGS(0.035)NS(0.015)NALVPVSWK 129.42 0.00017907 3662400.0 38242.0 29553.0 36320.0 38777.0 44914.0 29088.0 29458.0 41044.0 25846.0 37394.0 True False 36116.66273485535 31819.620072127705 33983.21074222602 33495.50570594392 39271.501783745516 33094.60796542629 30827.855369919616 41163.431244800006 31015.92219757827 36314.338058719964 0.9945565488886243 0.876227456512512 0.9358069720911744 0.9223768763671799 1.0814324006193874 0.9113372220061563 0.8489169021908439 1.1335310911695293 0.8540957609478051 1.0 15.148251662261847 -5.949460211042425 0.007619846103326567 1.8917238229964066 0.004606535035262771 0.01539453530336754 0.09008441368741324 31261.351432202267 58.10055052560479 6944.2303564634385 7446.868271232939 1.123413889287351e-06 5.949460211042425 -1.8871172879611438 STSSS(ph)SDTMSTFKPMVAPR ddPTM_A459_Selumetinib_30min_R2 1 STSSSSDTMSTFKPMVAPR 19 1 Q7Z6B7;Q7Z6B7-2;G5EA48 Q7Z6B7 SRGAP1 SLIT-ROBO Rho GTPase-activating protein 1 1 S(0.047)T(0.047)S(0.036)S(0.103)S(0.383)S(0.383)DT(0.001)MSTFKPMVAPR 103.31 0.00055618 9424900.0 21516.0 20469.0 24705.0 29212.0 25510.0 19201.0 17669.0 22190.0 19105.0 19261.0 True False 20320.226855372315 22038.906481791426 23115.50719677019 25233.27520648925 22305.20573770646 21845.763460676226 18490.64351045929 22254.569226247735 22926.533838301213 18704.884883912 1.086359364491447 1.1782433636224623 1.2358005590642127 1.3490206094875405 1.1924802465312727 1.1679175571652773 0.9885462340569132 1.189773118859919 1.2256976709875524 1.0 14.191127466639989 -6.916649561222034 3.9222528867158335 1.1126084567777084 1.2156437349720515 0.22464342989212138 0.09173207817960194 0.38090514958640326 11.328798564540502 0.035475090067694066 0.030758769003627947 1.2115753776954306e-07 6.916649561222034 0.1030352781943431 STSST(ph)SSGSNSNALVPVSWK ddPTM_A459_Selumetinib_30min_R1 1 STSSTSSGSNSNALVPVSWK 20 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 STS(0.003)S(0.028)T(0.906)S(0.047)S(0.014)GS(0.002)NSNALVPVSWK 243.37 4.7944999999999995e-30 8900700.0 2566.5 3451.0 3154.8 3447.9 2897.7 2839.7 2543.8 2700.4 1268.8 2223.3 True False 2626.294456460331 3046.9553156736256 2726.395488075964 2845.7889900988503 2635.603546630487 2811.135196241305 2351.9191179748714 2628.7766198645922 2153.060930514501 2508.6822117759234 1.0468820818086595 1.214564085228098 1.0867839199712421 1.1343760388384487 1.0505928308730321 1.1205624941435974 0.9375117768742508 1.0478715109968642 0.8582437904681142 1.0 11.292714013068709 -7.218996418971524 1.1699241552481636 0.9493792004344925 1.122257938403569 0.523563626472262 0.06637501407065403 0.3642912766090381 0.9787689143601956 0.04049218691224703 0.023944416289244954 6.039536093294915e-08 7.218996418971524 0.17287873796907638 STSTLEIQPSRAS(ph)PTSDIESVER ddPTM_A459_Selumetinib_30min_R1 4 STSTLEIQPSRASPTSDIESVER 23 1 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 STSTLEIQPS(0.186)RAS(0.599)PT(0.161)S(0.053)DIES(0.001)VER;STSTLEIQPS(0.005)RAS(0.681)PT(0.245)S(0.068)DIESVER;STSTLEIQPS(0.036)RAS(0.935)PT(0.023)S(0.006)DIESVER;STSTLEIQPS(0.006)RAS(0.859)PT(0.123)S(0.012)DIESVER 123.61 5.7418e-06 59550000.0 8382.800000000001 8057.999999999999 7233.6 8505.4 8454.9 6907.7 7963.6 7146.2 4604.93 6313.5 True False 8578.102929910643 7114.565613937435 6251.316851320618 7020.091556131779 7690.155787833832 6838.214809689775 7362.899240468857 6956.659561870964 7814.229879219848 7123.899223697787 1.2041303028789934 0.9986898172661814 0.8775133750524562 0.9854282515366458 1.0794868858128117 0.9598977462991507 1.033549045159992 0.9765241398600226 1.0969034841517216 1.0 12.79845139255308 -8.246481964573292 24.577789132409336 1.0484517663716377 1.009340797241886 0.02311578790518576 0.08350441948661838 2438.443149238223 4006836.3979005623 0.057158678889691505 0.021437738820019377 5.669151139445493e-09 8.246481964573292 -0.03911096912975176 STSTLEIQPSRAS(ph)PTSDIESVER ddPTM_A459_Selumetinib_30min_R2 1 STSTLEIQPSRASPTSDIESVER 23 1 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 STSTLEIQPS(0.005)RAS(0.479)PT(0.426)S(0.088)DIES(0.002)VER 130.57 4.2945e-06 16580000.0 44771.0 32491.0 37360.0 50974.0 39712.0 30260.0 29249.0 26902.0 26746.0 44353.0 True False 42282.807052513184 34982.95522496873 34956.298274492416 44031.253264945335 34723.023530215556 34428.04032706954 30609.136455793963 26980.280366134142 32095.947345679368 43072.41364706651 0.9816679278523064 0.8121893402960315 0.8115704534443509 1.0222611072074 0.8061545799298481 0.7993060386439313 0.7106436315968708 0.6263935099437284 0.7451624979429332 1.0 15.394476549636924 -6.669091353268002 2.6076409802787905 0.7446769143298796 0.894067068687696 0.20753727617294282 0.1104392648917743 0.37326680458094846 5.165470673912671 0.03946524864004888 0.038630265076653444 2.1424398943299674e-07 6.669091353268002 0.14939015435781644 STSTLEIQPSRASPT(ph)SDIESVER ddPTM_A459_Selumetinib_30min_R2 1 STSTLEIQPSRASPTSDIESVER 23 1 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 STSTLEIQPS(0.008)RAS(0.361)PT(0.468)S(0.163)DIESVER 99.881 7.026600000000001e-05 15110000.0 33370.0 29815.0 35697.0 38953.0 40433.0 21540.0 26854.0 26124.0 22011.0 36926.0 True False 31515.4289906941 32101.714629664923 33400.2938839549 33647.53420232699 35353.445064393774 24506.939479348235 28102.764210191508 26200.01651493899 26413.815038725366 35859.850434730004 0.8788499842757749 0.895199345242518 0.93141196851192 0.9383065962188063 0.985878207404742 0.6834088592743667 0.7836832521469244 0.7306225820050958 0.7365846404407693 1.0 15.130081850535344 -6.7556278141689345 24.99999919627497 0.7698252371431906 0.9252142379376185 0.4004209474422368 0.0837989069384766 125.09822729280333 538143.1098719588 0.026439721375409737 0.025761659031081883 1.755384203333735e-07 6.7556278141689345 0.15538900079442786 STSTPNVHMVS(ph)TTLPVDSR ddPTM_A459_Selumetinib_30min_R1 1 STSTPNVHMVSTTLPVDSR 19 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 STS(0.011)T(0.011)PNVHMVS(0.975)T(0.003)TLPVDSR 142.12 0.00035786 2698000.0 767.83 874.24 994.99 1016.0 1080.1 844.88 922.93 752.93 375.99 899.77 True False 785.7189450629013 771.8835743768508 859.8758230888498 838.5746726820474 982.4051457071429 836.3812742896627 853.3126470447943 732.9598505386783 638.0275687769129 1015.2642440019894 0.7739058572236704 0.7602784978758085 0.84694780513433 0.8259669121967071 0.9676349300303123 0.8238064910006068 0.8404833048007178 0.7219399824911416 0.6284349838441298 1.0 9.98763955285698 -13.936292663519588 17.073440615589693 0.9960515400581891 0.815423728246217 0.0 0.10368633496433012 0.0 0.0 0.0 0.023955358968099777 1.15799673924259e-14 13.936292663519588 -0.18062781181197207 STSTPTS(ph)PGPR ddPTM_A459_Selumetinib_30min_R1 6 STSTPTSPGPR 11 0 H3BUF6;H3BRB0;A0A0C4DGL7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 STSTPTS(1)PGPR;STSTPTS(1)PGPR;STSTPT(0.001)S(0.999)PGPR;STSTPTS(1)PGPR;STST(0.001)PT(0.092)S(0.907)PGPR;STST(0.014)PT(0.159)S(0.826)PGPR 163.46 0.00063861 390661400.0 34780.6 40271.2 43394.00000000001 47797.4 40898.600000000006 36333.9 38380.9 33672.299999999996 21875.1 27835.000000000004 True False 35590.920308733366 35556.22918242704 37501.3331461799 39450.481358319776 37199.3288512343 35968.413954541655 35485.79781236014 32779.20122095485 37120.44700590932 31407.893385860134 1.1331839379191357 1.1320794026394172 1.1940098205715077 1.2560690038536753 1.1843942665693548 1.145203007175727 1.1298369290929866 1.0436612484080858 1.1818827372427654 1.0 14.938839560244064 -7.2956809463458905 1.8698232650177262 1.0842005900737453 1.1811205342031137 0.3961568521908986 0.05452530521999484 0.3951267190805318 2.693295677206869 0.02954130387509988 0.018010919305867137 5.0619640170663875e-08 7.2956809463458905 0.09691994412936844 STSTPTS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 3 STSTPTSPGPR 11 0 H3BUF6;H3BRB0;A0A0C4DGL7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 STSTPT(0.003)S(0.997)PGPR;STSTPTS(1)PGPR;STST(0.003)PT(0.162)S(0.834)PGPR 121.29 0.0044846 98410400.0 312849.0 328937.0 318082.0 322094.0 325481.0 231619.0 301476.0 273530.0 244629.0 285180.0 True False 295462.1050137745 354165.41020084225 297616.9504214957 278224.24155685864 284591.1669429415 263522.41482205957 315495.23136336135 274325.9270146709 293561.6355053544 276946.1124133756 1.0668577451369368 1.2788242705938675 1.0746384841007135 1.0046150824517635 1.0276048450832007 0.9515295684263676 1.1391935731253253 0.9905390063941619 1.0599955094050142 1.0 18.07924576147999 -5.490091147267648 9.70499778576262 1.0272135523781158 1.1740170865004098 0.43589171759432743 0.06663859780906792 0.4147713394775426 119.0655192879568 0.016322688486930602 0.03326379788386777 3.2352575005073644e-06 5.490091147267648 0.14680353412229397 STSTPTSPGPR ddPTM_A459_Selumetinib_30min_R1 1 STSTPTSPGPR 11 0 H3BUF6;H3BRB0;A0A0C4DGL7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 0 167.12 0.0076903000000000015 2058300.0 738.46 818.77 1029.5 1005.5 828.5 831.96 953.21 930.4 392.12 562.14 False True 755.664681206973 722.908027764154 889.6995546387103 829.9083005726368 753.5623212835554 823.5912377592408 881.3086022662262 905.7227696348755 665.3990006883243 634.2961447072903 1.1913436452553103 1.1397011219384843 1.402656412249331 1.3083924717146374 1.1880291683489628 1.2984333022224261 1.3894276508221963 1.4279178222860567 1.049035227851475 1.0 9.30901276317903 -8.388684417126594 5.986290887285093 1.0041251707211676 1.2916364505294333 0.5774919944255508 0.09224228064706748 0.17353906819582057 7.275623198643023 0.0949386648169639 0.024633858881102238 4.0861620206461176e-09 8.388684417126594 0.28751127980826574 STSYGYS(ph)R ddPTM_A459_Selumetinib_30min_R1 3 STSYGYSR 8 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 STS(0.005)YGY(0.001)S(0.995)R;STSYGYS(1)R;STSYGYS(1)R 105.17 0.01427 203647000.0 9179.5 11954.3 8909.1 7917.0 9749.0 9235.099999999999 11396.0 9913.4 5577.5 9236.3 True False 9393.364489802296 10554.684998596702 7699.293154183323 6534.444570495841 8867.204671325746 9142.203278799896 10536.390545027763 9650.464428738576 9464.610135517518 10421.869074180704 0.9013128473349908 1.012743964011699 0.7387631814774634 0.6269935386814993 0.8508267191048766 0.8772134070892263 1.0109885731658994 0.9259821208699295 0.9081490151287053 1.0 13.347326415538182 -6.971771340676605 3.2124705420952497 0.9548757818464361 0.8210123781399917 0.2919579762886533 0.09851759751172326 0.3770819728920526 8.058904767001689 0.04288482843647076 0.03553974679016919 1.0671578400018829e-07 6.971771340676605 -0.13386340370644434 STSYGYS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 STSYGYSR 8 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 STSYGYS(1)R 109.83 0.012283 98512000.0 140710.0 136290.0 166100.0 149150.0 190540.0 158670.0 197750.0 130860.0 136700.0 151450.0 True False 132889.9015067596 146743.00475857875 155413.30683600585 128835.51270189902 166602.6617507875 180525.35223714876 206945.7668341912 131240.78093496087 164043.8197171301 147077.24498564293 0.9035381477245631 0.9977274511288486 1.056678120746528 0.8759717569803228 1.1327562041772712 1.2274186415088948 1.4070549584634413 0.892325532394709 1.1153582577178636 1.0 17.16621453213923 -6.3320777088065245 8.652471528336616 1.1429940614851506 0.9684445115855723 0.2726889937052367 0.13505282183515877 0.532335945147813 61.3809870352818 0.04347391611739859 0.049322055926289306 4.6550279312545034e-07 6.3320777088065245 -0.17454954989957827 STT(ph)PPPAEPVSLPQEPPK ddPTM_A459_Selumetinib_30min_R1 3 STTPPPAEPVSLPQEPPK 18 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.141)T(0.141)T(0.718)PPPAEPVSLPQEPPK;S(0.017)T(0.025)T(0.958)PPPAEPVSLPQEPPK;S(0.085)T(0.085)T(0.826)PPPAEPVS(0.004)LPQEPPK 154.81 8.246700000000001e-05 89913000.0 25688.3 29839.7 26966.7 28115.5 27593.3 25457.199999999997 29588.3 27945.0 16250.900000000001 25243.0 True False 26286.78740926939 26346.054051899824 23304.770257480057 23205.655718299335 25097.4908869928 25201.1236812882 27356.43070932301 27203.80782184715 27576.59038122485 28483.18493764207 0.9228879237633983 0.9249686827361111 0.8181939733390399 0.8147142171461242 0.8811335860767842 0.8847719711282552 0.9604414242723961 0.9550830737996524 0.9681708854398826 1.0 14.797822854394346 -7.247037894569886 2.3083917041107918 0.9716033588187739 0.8690349923976243 0.6373880854264509 0.03579564474084708 0.2304333268837896 2.408619836918993 0.01908883419964711 0.012650152768898235 5.6618988371745226e-08 7.247037894569886 -0.10256836642114964 STT(ph)PPPAEPVSLPQEPPK ddPTM_A459_Selumetinib_30min_R2 4 STTPPPAEPVSLPQEPPK 18 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.02)T(0.02)T(0.96)PPPAEPVSLPQEPPK;S(0.018)T(0.018)T(0.964)PPPAEPVSLPQEPPK;S(0.032)T(0.045)T(0.922)PPPAEPVS(0.002)LPQEPPK;S(0.187)T(0.047)T(0.766)PPPAEPVSLPQEPPK 142.74 0.00069916 129366000.0 545499.0 474937.0 525995.0 531773.0 503108.0 415392.0 447175.0 483506.0 342838.0 468602.0 True False 515182.3493855149 511363.1407368497 492153.0543600538 459344.6000404079 439903.0751974134 472608.4774468629 467969.5235604529 484912.9224112724 411415.1796940855 455072.2426857865 1.1320891521420098 1.1236966195055986 1.081483351863916 1.009388305754283 0.9666664628920315 1.0385350568902632 1.0283411723785834 1.0655735000433546 0.9040656429976001 1.0 18.795736065663085 -5.595822064959359 2.596397976219483 1.005124282938694 1.1271880741517697 0.6119977535265972 0.041384033782167505 0.18998579788990955 2.571545122304802 0.01177723723168661 0.024703814756298445 2.5361675123053573e-06 5.595822064959359 0.12206379121307576 STT(ph)PPPAEPVSLPQEPPKPR ddPTM_A459_Selumetinib_30min_R1 1 STTPPPAEPVSLPQEPPKPR 20 1 Q9UN86-2 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.148)T(0.148)T(0.704)PPPAEPVSLPQEPPKPR 196.75 2.1949000000000002e-15 1046300000.0 4705.0 5053.2 5748.5 5345.3 4674.4 4430.7 4719.2 4450.4 2418.1 4211.5 True False 4814.617345663691 4461.568994831055 4967.885274250247 4411.843698708019 4251.601345332349 4386.131180753722 4363.2269445502825 4332.360935063467 4103.339088963678 4752.087048483922 1.0131584915305198 0.9388651658337039 1.0454112526905777 0.928401280047163 0.8946808637877867 0.9229904957555538 0.9181706690205308 0.9116754156356706 0.8634814655326616 1.0 12.214345548255698 -5.916514576646551 7.96225266298834 0.9140497948174495 0.9928315107914514 0.4408178876779909 0.040643234276555425 0.2154719612027568 17.941360115030722 0.010706672836488318 0.015933024747531374 1.2119520101724938e-06 5.916514576646551 0.07878171597400185 STT(ph)PPPAEPVSLPQEPPKPR ddPTM_A459_Selumetinib_30min_R2 5 STTPPPAEPVSLPQEPPKPR 20 1 Q9UN86-2 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.157)T(0.157)T(0.686)PPPAEPVSLPQEPPKPR;S(0.15)T(0.15)T(0.7)PPPAEPVSLPQEPPKPR;S(0.158)T(0.158)T(0.684)PPPAEPVSLPQEPPKPR;S(0.147)T(0.147)T(0.705)PPPAEPVSLPQEPPKPR;S(0.139)T(0.139)T(0.722)PPPAEPVSLPQEPPKPR 169.84 2.9141e-09 5846626000.0 1943588.0 2202819.0 1991390.0 2307709.0 2097008.0 1549076.0 1760248.0 1714147.0 1382322.0 1873668.0 True False 1835571.1597592174 2371768.1341205356 1863266.135461491 1993395.0531799316 1833563.1075506222 1762447.157888156 1842103.0198652425 1719134.883977688 1658825.0253037505 1819570.3364658956 1.008793737165665 1.3034770278389785 1.024014350047311 1.0955306388714003 1.007690151243015 0.9686062267377425 1.012383518761419 0.9448026545193736 0.9116575446737846 1.0 20.79516638973115 -6.129899860337426 1.038054837881345 0.9604487675437767 1.147095365259701 0.4228145398563635 0.07831353209321432 0.47295529125131885 1.0550983429987504 0.03194782512467868 0.057100116121975505 7.414811923944347e-07 6.129899860337426 0.18664659771592418 STT(ph)PTSSPFR ddPTM_A459_Selumetinib_30min_R1 2 STTPTSSPFR 10 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.054)T(0.054)T(0.782)PT(0.028)S(0.068)S(0.015)PFR;S(0.077)T(0.007)T(0.9)PT(0.005)S(0.011)SPFR 123.51 0.0096578 371610000.0 13191.0 16817.1 16451.6 17756.300000000003 16482.7 13173.1 14001.0 12620.2 7218.799999999999 11020.2 True False 13498.324634782082 14848.146113942323 14217.563082170194 14655.495532031733 14991.842695257033 13040.59057421782 12944.893297730234 12285.471299813038 12249.776359708449 12434.750015838184 1.0855324487898204 1.194084810312245 1.14337345455769 1.178591890738855 1.2056408593789076 1.048721571210356 1.0410256162160298 0.987995036825428 0.9851244571950273 1.0 13.602089883924878 -6.917734235560037 4.0117573980279 1.006660697274162 1.1629059262758392 0.8272014233510474 0.03438956239208729 0.09043136907005678 2.801416264826703 0.012887124082024663 0.011182329606399092 1.2085531772265835e-07 6.917734235560037 0.15624522900167714 STT(ph)PTSSPFR ddPTM_A459_Selumetinib_30min_R2 3 STTPTSSPFR 10 0 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;H7C5N8;A0A2R8Y7F4;A0A2R8YET2;A0A2R8Y424 E7EPN9 PRRC2C Protein PRRC2C 1 STT(0.893)PT(0.027)S(0.076)S(0.003)PFR;S(0.019)T(0.009)T(0.828)PT(0.039)S(0.084)S(0.02)PFR;S(0.366)T(0.025)T(0.518)PT(0.033)S(0.048)S(0.01)PFR 126.39 0.008103399999999998 295977000.0 1355260.0 1368760.0 1415590.0 1393670.0 1610480.0 1089194.0 1038320.0 1200260.0 944075.0 1228160.0 True False 1279940.0747356329 1473739.4907429218 1324512.4805778584 1203849.7417851514 1408157.1045261256 1239220.5867813008 1086603.9373920467 1203752.5578862617 1132916.3796594697 1192699.8296570957 1.0731451811338137 1.2356331862364949 1.1105161983285092 1.00934846459336 1.1806466887238296 1.0390045810080981 0.9110456045796939 1.0092669823155285 0.9498755273447017 1.0 20.185799570651874 -6.988482310749469 6.042182554015708 0.9687898092872151 1.1208204907158816 0.583221787774532 0.061570486797851126 0.114690744711559 16.072697566454806 0.022511466233411218 0.01912926182913574 1.0268752564770707e-07 6.988482310749469 0.1520306814286665 STT(ph)SVSEEDVSSR ddPTM_A459_Selumetinib_30min_R1 2 STTSVSEEDVSSR 13 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 STT(0.446)S(0.446)VS(0.108)EEDVSSR;STT(0.788)S(0.209)VS(0.003)EEDVSSR 234.87 2.2212e-13 84523000.0 4968.8 5407.6 5117.700000000001 6133.8 5539.799999999999 5047.7 4701.1 4876.9 2820.8 3767.5 True False 5084.563372398244 4774.475678074963 4422.744449513872 5062.646975686165 5038.726068131125 4996.924720944901 4346.492242122676 4747.54876959622 4786.691576919378 4251.095323557684 1.1960596000333958 1.1231165887099583 1.0403776233868443 1.1909041294913387 1.1852771308628958 1.1754440539721989 1.0224405503297807 1.1167824779857114 1.125990177259413 1.0 12.053618893976056 -10.311384462045813 0.2862374389636294 0.9338983178764283 1.149371153732822 0.355191465866183 0.05586788746666406 15.132819842395115 1.1952886833590093 0.928619801672099 0.075292734039433 4.8821996804544344e-11 10.311384462045813 0.21547283585639365 STT(ph)TGHLIYK ddPTM_A459_Selumetinib_30min_R2 1 STTTGHLIYK 10 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A6PW80;Q5JR01;A0A2R8Y660;A0A2R8Y488;A0A2R8YDN5 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 S(0.063)T(0.089)T(0.424)T(0.424)GHLIYK 96.604 0.029175 33162000.0 157320.0 125920.0 159880.0 149960.0 189280.0 142860.0 146110.0 159210.0 151050.0 157600.0 True False 148576.78420185795 135577.65910338427 149593.49486418196 129535.18930457083 165500.9542153306 162537.66824603963 152904.4045114726 159673.27474136546 181264.22068963124 153049.67850602424 0.9707748859858584 0.8858408617829782 0.9774178967536594 0.8463604142721028 1.0813544715078658 1.0619928759905362 0.9990508049675784 1.043277426649939 1.1843489150648325 1.0 17.223640488800235 -6.275981435399588 24.876208187526508 1.0607197362884384 0.9217457797826626 0.5719962380990993 0.05998426959181833 547.949548595026 937341.6046380752 0.018146563769921645 0.020670588725993998 5.296860856722114e-07 6.275981435399588 -0.13897395650577582 STTPPPAEPVS(ph)LPQEPPK ddPTM_A459_Selumetinib_30min_R1 1 STTPPPAEPVSLPQEPPK 18 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 S(0.036)T(0.036)T(0.187)PPPAEPVS(0.74)LPQEPPK 79.471 0.015144 14861000.0 6563.9 8119.1 8456.1 8027.5 8408.2 7893.9 8271.6 8091.7 4874.3 7351.3 True False 6716.826098873937 7168.511997532813 7307.808066032438 6625.6478198377345 7647.679794588278 7814.494533087733 7647.66655249663 7877.08183045413 8271.331095213454 8294.910962725833 0.8097526458158252 0.8642060209862858 0.8809989762242103 0.7987605713443905 0.9219724996391203 0.9420829913911182 0.9219709032275726 0.9496282559090425 0.9971573091479418 1.0 13.018010780089964 -6.930972293664722 0.5127750429169876 1.001833206383939 0.8241034417946664 0.787549070768294 0.03054869297937289 0.47032646463083055 0.2650412952382407 0.02899980449937848 0.032591446148031014 1.1722701495372144e-07 6.930972293664722 -0.1777297645892726 STTS(ph)VSEEDVSSR ddPTM_A459_Selumetinib_30min_R2 2 STTSVSEEDVSSR 13 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 STT(0.028)S(0.965)VS(0.006)EEDVSSR;STT(0.025)S(0.974)VSEEDVSSR 169.58 0.00025018 89095000.0 223780.0 250790.0 276380.0 283700.0 272030.0 253820.0 271310.0 230790.0 242030.0 283050.0 True False 211343.20346231695 270024.7865830512 258598.0116997919 245059.57059020275 237855.1594209442 288781.4010514471 283926.4525905658 231461.56069065892 290442.7628832266 274877.61104777985 0.7688629228721753 0.9823455084383532 0.9407750988305913 0.8915224839741711 0.8653129606092207 1.0505817478210346 1.0329195291980802 0.842053158889051 1.0566257534621153 1.0 18.06842987766546 -6.749878798576402 24.999867870780733 0.9888445845876738 0.8978388856684169 0.32150630816923054 0.0766407653039538 320.12499668512226 692272.1721741711 0.025293522974610207 0.025088526353005656 1.7787757554508952e-07 6.749878798576402 -0.09100569891925692 STTSAS(ph)TSEEEK ddPTM_A459_Selumetinib_30min_R1 1 STTSASTSEEEK 12 0 Q8N5F7 Q8N5F7 NKAP NF-kappa-B-activating protein 1 STTS(0.006)AS(0.502)T(0.337)S(0.155)EEEK 150.69 0.00054248 2041800.0 1882.6 1742.5 1509.4 1629.6 1319.1 1366.0 1569.3 1400.3 790.67 1267.4 True False 1926.4609170980787 1538.4872899337265 1304.431770540718 1345.020951380575 1199.7876379060206 1352.259280228764 1450.9264375493217 1363.1594951845605 1341.70924174803 1430.0831355214355 1.3470971506811416 1.0758026940669885 0.9121370206670519 0.9405194131529667 0.8389635596035158 0.9455808873207253 1.014574888347513 0.9532029721387677 0.9382036669209566 1.0 10.481883302797357 -4.813889358268288 2.3660784509066373 0.9402510663970661 1.4273601779072305 0.87790948220521 0.04588926862430359 0.17326611893073057 1.262171900708087 0.012802448080134187 0.17184643876854933 1.5350079946996675e-05 4.813889358268288 0.48710911151016434 STTSAST(ph)SEEEK ddPTM_A459_Selumetinib_30min_R2 1 STTSASTSEEEK 12 0 Q8N5F7 Q8N5F7 NKAP NF-kappa-B-activating protein 1 STTSAS(0.007)T(0.496)S(0.496)EEEK 177.81 2.9159000000000007e-08 0.0 35470.0 21365.0 25639.0 32856.0 30135.0 25866.0 42759.0 53620.0 31892.0 39476.0 True False 33498.71939766016 23003.626800697337 23989.41465363251 28380.956120238636 26349.17188968186 29428.806711830155 44747.37822535112 53776.02532273117 38271.291136932865 38336.225309034315 0.8738137134687033 0.600049342762922 0.6257636076648152 0.7403169167401147 0.6873178482565004 0.7676500874720955 1.1672348507093617 1.4027470072818649 0.9983061928612427 1.0 15.226420671797323 -7.225846010945196 4.227914290154288 1.1790980302820504 0.7008455001609422 0.7267060643302474 0.12763343704001257 0.10158880063781567 4.176372152726734 0.050428953964123294 0.03694678130537824 5.945029158731326e-08 7.225846010945196 -0.47825253012110824 STTSQVTPAEEKDGHS(ph)PMSK ddPTM_A459_Selumetinib_30min_R2 1 STTSQVTPAEEKDGHSPMSK 20 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 STTSQVT(0.038)PAEEKDGHS(0.949)PMS(0.013)K 74.732 0.0027221 12268000.0 45108.0 38387.0 51338.0 59209.0 49241.0 33774.0 36104.0 41484.0 25715.0 47197.0 True False 42601.077941631054 41331.159466340665 48034.9689725881 51144.63205877797 43054.90535987473 38426.06193015356 37782.90753871878 41604.71157195412 30858.718537132452 45834.299977467126 0.9294584615140719 0.9017517336723747 1.0480135836306623 1.1158593473429612 0.9393599418130354 0.8383691241939863 0.8243369606886863 0.9077200173758007 0.6732669322385875 1.0 15.484140019072784 -6.6259576641300555 4.158642369006745 0.8418068502327422 0.9986677007621495 0.35949891196530537 0.09426752615788553 0.24088512369469042 7.59958339899977 0.03215308978587048 0.03210708631694673 2.366150343176642e-07 6.6259576641300555 0.15686085052940735 STTSVS(ph)EEDVSSR ddPTM_A459_Selumetinib_30min_R1 2 STTSVSEEDVSSR 13 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 STTSVS(0.999)EEDVSSR;STTS(0.001)VS(0.999)EEDVSSR 257.2 1.5732e-29 45005000.0 3542.3 4253.6 3626.3 4026.0 4293.3 3780.4 3380.0 3590.1 2097.91 3252.7 True False 3624.8286978840565 3755.586534555008 3133.868377840075 3322.934677379845 3904.9717730436796 3742.372608328564 3125.043878746389 3494.8788857117006 3560.000044716013 3670.2157289810416 0.9876336884672483 1.0232604325952435 0.853864897666418 0.9053785724749178 1.0639624647153405 1.0196601193705732 0.8514605433326917 0.9522271015611337 0.9699702436031934 1.0 11.841649149361128 STTSVS(ph)EEDVSSR ddPTM_A459_Selumetinib_30min_R2 1 STTSVSEEDVSSR 13 0 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 STTS(0.002)VS(0.998)EEDVS(0.001)SR 164.92 0.00036256 30187000.0 33177.0 26916.0 43783.0 47511.0 43082.0 25890.0 39026.0 33641.0 29055.0 32685.0 True False 31333.15515805388 28980.370651419107 40966.049447326026 41039.91983895351 37669.65400203332 29456.112493979854 40840.78632855193 33738.889740432634 34866.811864529795 31741.299124171295 0.987141548160308 0.9130177860095929 1.2906229605495259 1.2929502248287383 1.1867710220262386 0.9280058884404246 1.2866765839918406 1.062933486384625 1.0984683307425938 1.0 14.954073556293558 -5.241405906713587 24.924266685767684 1.1498793865829118 0.9500796308315992 0.29058322353493127 0.12041346934982927 982.6409159257477 1222529.2781934189 0.031069602635642707 0.0819664334727443 5.7358012369178415e-06 5.241405906713587 -0.1997997557513126 STTT(ph)GHLIYK ddPTM_A459_Selumetinib_30min_R2 2 STTTGHLIYK 10 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A6PW80;Q5JR01;A0A2R8Y660;A0A2R8Y488;A0A2R8YDN5 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 S(0.153)T(0.212)T(0.212)T(0.422)GHLIYK;STT(0.109)T(0.891)GHLIYK 131.83 0.0059492 28505000.0 130748.0 110564.0 156165.0 165812.0 199056.0 130653.0 123911.0 167391.0 138361.0 154450.0 True False 123481.54958571392 119043.90328070696 146117.51391959598 143228.11955834573 174048.80569678155 148649.26480015254 129673.10702498847 167878.08009692832 166037.06612934815 149990.62719070714 0.8232617724086987 0.7936756150059121 0.9741776313383459 0.9549137985551381 1.1603978792320495 0.9910570252576576 0.8645414013777958 1.119257137870875 1.1069829444625137 1.0 17.194512824971497 -5.422764187886801 1.9251359458541686 1.032437164611997 0.7980999992016803 0.5251674120472589 0.08206912577941368 0.30076171024788867 2.102415007582552 0.02497065567768919 0.07724692132251583 3.777772597821721e-06 5.422764187886801 -0.23433716541031668 STTTGHLIYK ddPTM_A459_Selumetinib_30min_R1 2 STTTGHLIYK 10 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A6PW80;Q5JR01;A0A2R8Y660;A0A2R8Y488;A0A2R8YDN5 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 ; 119.68 0.007481100000000002 79239000.0 28806.0 29716.0 28689.0 31988.0 38467.0 27475.0 35575.0 28051.0 9783.400000000001 16471.1 False True 29477.123753281234 26236.836905406402 24793.19137739676 26401.89628912732 34987.66664190046 27198.62644530402 32891.5491084032 27306.99635751063 16601.71524873548 18585.32612710044 1.5860428572355678 1.4116963418332922 1.3340197103802358 1.4205775087599373 1.8825425178244641 1.4634462833366146 1.7697590498797837 1.469277222835093 0.8932700526856758 1.0 14.181876383747097 -8.217038543890252 5.235142605845927 0.9437337755793622 1.5464502989349658 0.6874812187247843 0.16099547513558732 0.10725066732783416 7.181141914707905 0.12490709067163562 0.0430333178762887 6.066824837724858e-09 8.217038543890252 0.6027165233556036 STTTGHLIYK ddPTM_A459_Selumetinib_30min_R2 1 STTTGHLIYK 10 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A6PW80;Q5JR01;A0A2R8Y660;A0A2R8Y488;A0A2R8YDN5 P68104 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 107.83 0.015526 40465000.0 131350.0 134280.0 194580.0 237700.0 255420.0 157360.0 146630.0 162370.0 166720.0 195100.0 False True 124050.09283571085 144578.84422174733 182060.93464268537 205324.84994462886 223331.85611622856 179034.9116281448 153448.58554183273 162842.46981819946 200068.6585460125 189466.9560693231 0.6547320725959349 0.7630821079367958 0.9609112766664812 1.0836974119619234 1.1787377638268217 0.9449400325122584 0.8098962939251962 0.859476888194783 1.0559554166944574 1.0 17.531586731952885 -5.153668310157286 2.82896705810768 0.9858686159353243 0.6683797450784078 0.5608411734535517 0.10060162943609977 0.23790319060557746 3.5386004788154266 0.030721194184896196 0.11424297114661751 7.019912353899608e-06 5.153668310157286 -0.31748887085691646 STVGSSDNSS(ph)PQPLK ddPTM_A459_Selumetinib_30min_R1 3 STVGSSDNSSPQPLK 15 0 Q9UHG0 Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 1 STVGSS(0.002)DNS(0.197)S(0.801)PQPLK;STVGSSDNS(0.225)S(0.775)PQPLK;STVGSSDNS(0.336)S(0.664)PQPLK 225.21 3.097e-10 35716900.0 15927.900000000001 18615.4 20352.6 21960.300000000003 20785.3 16386.0 20452.1 17307.0 9872.2 17348.1 True False 16298.989079701734 16435.90031393532 17588.82870882935 18125.345850885413 18905.27328494277 16221.171717297604 18909.38163091982 16847.96213894109 16752.402363040073 19574.89761980385 0.8326474751628896 0.8396416999549045 0.8985400102953692 0.9259484367646484 0.9657916813734124 0.8286721101870135 0.9660015596602287 0.860692222568565 0.8558104715751734 1.0 14.256717141533835 STVGSSDNSS(ph)PQPLK ddPTM_A459_Selumetinib_30min_R2 4 STVGSSDNSSPQPLK 15 0 Q9UHG0 Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 1 STVGSSDNS(0.226)S(0.774)PQPLK;STVGS(0.001)S(0.007)DNS(0.465)S(0.528)PQPLK;STVGSS(0.001)DNS(0.078)S(0.921)PQPLK;STVGSSDNS(0.022)S(0.978)PQPLK 285.04 9.588e-56 65684000.0 236723.0 220447.0 247971.0 262217.0 295152.0 204148.0 221031.0 240889.0 175887.0 213934.0 True False 223566.88333725117 237354.576051174 232016.81583041052 226502.59225044525 258072.36706764178 232267.53392896889 231309.3794646178 241589.94710867948 211069.31469339353 207757.16955271442 1.0760970791938198 1.1424615408564747 1.1167692375186151 1.0902275610420007 1.2421827252616706 1.117976021857746 1.1133641258331037 1.1628477016162884 1.0159423867191197 1.0 17.664538738675134 -8.274838243224778 19.780113746065634 1.0079702463917022 1.1336252929297204 0.5675217300367374 0.043561710403087296 39.238231334431326 57915.440871728824 0.03997227579439375 0.010756044206462036 5.3108221360999006e-09 8.274838243224778 0.12565504653801818 STVGSSDNSS(ph)PQPLKR ddPTM_A459_Selumetinib_30min_R1 2 STVGSSDNSSPQPLKR 16 1 Q9UHG0 Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 1 STVGS(0.001)SDNS(0.225)S(0.774)PQPLKR;STVGSSDNS(0.353)S(0.647)PQPLKR 256.8 1.2230999999999998e-38 7662400.0 5229.1 6822.6 7583.6 7464.6 7052.0 6011.7 6953.2 6003.8 3417.2 5975.5 True False 5350.927855942614 6023.8068202593095 6553.788773733005 6161.047737896079 6414.1478451317225 5951.227756186868 6428.714525946566 5844.559720909142 5798.738817586818 6742.513631298989 0.79361023922939 0.8934066951376387 0.9720097180538254 0.913761258011593 0.9512992032165897 0.8826423025028909 0.9534596261109868 0.8668220845380997 0.8600262653780729 1.0 12.719070817813744 -4.798226203641824 3.7734397676709723 0.9209337361144696 0.7828821863155074 0.44665094458164134 0.043673076097637126 0.22383493899212265 5.614726142076879 0.010759979833931677 0.08346541375762732 1.591379636082327e-05 4.798226203641824 -0.13805154979896217 STVGSSDNSS(ph)PQPLKR ddPTM_A459_Selumetinib_30min_R2 2 STVGSSDNSSPQPLKR 16 1 Q9UHG0 Q9UHG0 DCDC2 Doublecortin domain-containing protein 2 1 STVGS(0.034)S(0.008)DNS(0.099)S(0.859)PQPLKR;STVGS(0.001)S(0.001)DNS(0.026)S(0.973)PQPLKR 85.20299999999997 0.0084654 77681000.0 126509.0 128554.0 129140.0 150089.0 153754.0 98047.0 109182.0 125810.0 102633.0 117767.0 True False 119478.13623565224 138413.6784337394 120831.27299700065 129646.61928203334 134438.04794180012 111552.08426795069 114259.17934002876 126176.08627103324 123162.46780561961 114366.76071458717 1.0446928416012498 1.2102614218405954 1.0565243978409624 1.1336040163415877 1.1754993068073571 0.9753890341122735 0.9990593300545874 1.1032583722985505 1.0769078973302648 1.0 16.80330828599198 -6.757508871166902 24.99969307397922 1.0353851010352095 1.125674207537038 0.3917235867508645 0.05791566047971599 112.62806137603584 716362.344827854 0.01949852014267028 0.01881687127494018 1.7477975604628082e-07 6.757508871166902 0.09028910650182853 STVTGERQS(ph)GDGQESTEPVENK ddPTM_A459_Selumetinib_30min_R1 3 STVTGERQSGDGQESTEPVENK 22 1 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 STVTGERQS(1)GDGQESTEPVENK;S(0.003)T(0.003)VT(0.027)GERQS(0.606)GDGQES(0.278)T(0.083)EPVENK;STVT(0.003)GERQS(0.997)GDGQESTEPVENK 146.91 2.2382e-07 223599000.0 11364.0 12734.9 12133.4 13419.900000000001 18672.9 11211.0 14578.800000000001 11193.1 5525.469999999999 7665.4 True False 11628.759089505238 11243.891987705616 10485.750923995463 11076.366387722255 16983.93949196826 11098.22751877356 13479.10937854078 10896.222627687148 9376.319025638371 8649.328757318923 1.3444695439128926 1.299972784384131 1.212319616724314 1.2806041599875149 1.9636135899675133 1.2831316545093072 1.5583994731539108 1.2597766755561164 1.08405164015812 1.0 13.07837245948507 -8.158309864710759 2.6393486789886285 1.0212019452739174 1.418017589687258 0.3486408978865271 0.20537182659783135 0.3409002659173791 4.253767771823578 0.18511477465542786 0.056972052219413045 6.945286016482547e-09 8.158309864710759 0.3968156444133406 STVTGERQS(ph)GDGQESTEPVENK ddPTM_A459_Selumetinib_30min_R2 2 STVTGERQSGDGQESTEPVENK 22 1 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 STVT(0.003)GERQS(0.996)GDGQESTEPVENK;S(0.001)T(0.001)VT(0.001)GERQS(0.677)GDGQES(0.236)T(0.083)EPVENK 92.363 0.00017677 37977000.0 73980.0 74804.0 125336.0 139228.0 186824.0 112568.0 73819.0 94482.0 134399.0 136486.0 True False 69868.48776540448 80541.22626722956 117272.01821551884 120264.90621830353 163353.4988922491 128073.22020943718 77251.72976957349 94756.92697766282 161282.55542181848 132545.29454678457 0.5271291448278684 0.6076505887487458 0.8847693810369502 0.9073494961064316 1.2324352927865738 0.9662600294288917 0.5828326839796332 0.7149022324909198 1.2168108718856896 1.0 17.016125928840275 -5.2328493852880795 2.7192513943156986 0.9307827385294766 0.5338697241514886 0.3929128621986153 0.18634193308631705 0.32446879130340567 4.641786803973024 0.05434178892250068 0.17973556979141178 5.849929263825423e-06 5.2328493852880795 -0.396913014377988 STVTGERQS(ph)GDGQESTEPVENKVGK ddPTM_A459_Selumetinib_30min_R1 1 STVTGERQSGDGQESTEPVENKVGK 25 2 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 S(0.056)T(0.056)VT(0.056)GERQS(0.819)GDGQES(0.006)T(0.006)EPVENKVGK 54.857 0.0053621 7058600.0 505.03 268.16 2348.0 1953.8 1100.6 329.18 342.35 466.6 456.88 228.77 True False 516.7962163826847 236.76370253579813 2029.1544966407885 1612.605507368291 1001.0509243267114 325.86874807152606 316.5262638724338 454.2242522695967 775.2919908050636 258.1348579085048 2.0020396337400577 0.9172093395449846 7.860831013221844 6.247143529681198 3.8780152840943756 1.2623973015958556 1.2262050404080866 1.7596393449140266 3.003437804125872 1.0 8.011981162419733 -6.690178946610342 5.437624786513533 1.673705786963499 4.357587261454676 0.30820525412689526 1.895012590430113 0.282016444713938 15.089926921850214 0.7015391324646598 0.6938078469231033 2.0408968406764939e-07 6.690178946610342 2.6838814744911774 STVTGERQSGDGQES(ph)TEPVENK ddPTM_A459_Selumetinib_30min_R1 1 STVTGERQSGDGQESTEPVENK 22 1 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 S(0.003)T(0.003)VT(0.014)GERQS(0.112)GDGQES(0.434)T(0.434)EPVENK 50.957 0.026686 3142400.0 955.53 1011.1 934.98 1398.0 1055.2 1019.5 1155.0 834.5 633.74 846.14 True False 977.7919898622794 892.7199419523628 808.0148514775145 1153.86554371014 959.757346310691 1009.2447556319364 1067.8774201041651 812.366349161977 1075.4104934617428 954.7503111015515 1.0241337221813978 0.9350297471203538 0.8463101211721632 1.2085521526343967 1.0052443399608455 1.0570771686552387 1.1184886851433358 0.8508678548894133 1.1263787829730882 1.0 9.898979674718971 -5.73462891414988 24.999991430276804 1.0471461994675377 0.9351451367333488 0.23022233873324394 0.0978940897793254 343.52976679645974 320329.0729625113 0.025890648709663143 0.04482789636138849 1.8423455336866346e-06 5.73462891414988 -0.11200106273418897 SVAAEGALLPQT(ph)PPSPR ddPTM_A459_Selumetinib_30min_R1 1 SVAAEGALLPQTPPSPR 17 0 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 SVAAEGALLPQT(0.999)PPS(0.001)PR 160.09 6.507899999999999e-05 39591000.0 998.88 1359.9 1317.1 1165.6 1287.8 1416.1 1211.5 990.01 619.09 967.37 True False 1022.1519605178627 1200.6822757996415 1138.2450543124285 962.0498410218456 1171.3187173795561 1401.8553197159242 1120.1155796157536 963.7517187943072 1050.5505134554087 1091.5413624817506 0.9364298923074039 1.0999878860016314 1.0427869189716195 0.8813681955528552 1.073086882128243 1.284289691531833 1.0261778601490978 0.8829273465213464 0.9624468202165566 1.0 10.092151085001477 -7.568569182724175 9.84329683362072 0.9441841685088131 1.0566780528866337 0.16969280555553323 0.10321892883481078 0.7296306794781745 150.4725106542983 0.05160149692309538 0.029776636816515455 2.700416900052549e-08 7.568569182724175 0.1124938843778206 SVAAEGALLPQTPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SVAAEGALLPQTPPSPR 17 0 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 S(0.024)VAAEGALLPQT(0.35)PPS(0.626)PR 147.25 0.00039561 37756000.0 1733.5 1885.8 1815.4 2165.2 1943.9 1695.4 1375.6 1623.1 866.42 1612.5 True False 1773.8871771961751 1665.0096593153642 1568.878651278401 1787.0884658377659 1768.0745882234203 1678.3458153000356 1271.8373844980867 1580.0501154281656 1470.2514591869287 1819.4800820800967 0.9749417950034396 0.9151018885636075 0.8622675602388574 0.982197322981794 0.9717471521876141 0.9224315406526951 0.6990114357526109 0.8684074813403805 0.8080613102980951 1.0 10.829310542688848 -7.030379625699358 24.94082760354516 0.8297350651458211 0.9386256514154332 0.2612945376266842 0.07664361350743945 793.3329581114077 651301.8181867755 0.02793205030692935 0.021666471135336075 9.324388805427988e-08 7.030379625699358 0.10889058626961212 SVAAEGALLPQTPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 SVAAEGALLPQTPPSPR 17 0 Q86X27;Q86X27-3;H7C2H2 Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 1 SVAAEGALLPQT(0.064)PPS(0.936)PR;SVAAEGALLPQT(0.098)PPS(0.902)PR;SVAAEGALLPQT(0.004)PPS(0.996)PR;SVAAEGALLPQT(0.001)PPS(0.999)PR 231.4 1.726e-16 50922600.0 177030.0 150700.0 180597.0 191068.0 195126.0 125049.0 138337.0 149793.0 124819.0 150192.0 True False 167191.38130723918 162258.20542312632 168977.58563914616 165044.20878931574 170612.52743142718 142273.36466819953 144769.94460956505 150228.872830434 149786.28773425397 145855.56671431995 1.1462804270933904 1.1124580917842746 1.1585268183155062 1.13155920275967 1.1697361388036527 0.9754400731709013 0.9925568688997571 1.0299838135398687 1.0269494069268739 1.0 17.154180923531214 -6.760665238957678 24.99999972514635 1.0060831884890293 1.1421236851888477 0.9195776607536588 0.020508700012230607 5.676690933522785 183325.87944455858 0.007236952984653037 0.006835084220007268 1.7351409564532688e-07 6.760665238957678 0.13604049669981833 SVAGKEDNTDT(ph)DQEK ddPTM_A459_Selumetinib_30min_R2 1 SVAGKEDNTDTDQEK 15 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 1 SVAGKEDNT(0.151)DT(0.849)DQEK 109.13 0.031764999999999995 0.0 18845.0 11733.0 12257.0 11722.0 10905.0 10739.0 14428.0 16912.0 9673.0 9808.6 True False 17797.67034251213 12632.883372458788 11468.39796441256 10125.443378422124 9535.016408063064 12218.199771064106 15098.930588539626 16961.211120067674 11607.870286201909 9525.400232196629 1.8684433103770857 1.3262312411565251 1.2039806921339054 1.0629940088183696 1.0010095298498778 1.2826967343341222 1.585122957616417 1.7806297590244446 1.218622840326054 1.0 13.217563996782422 -7.148521048751254 7.847452589191453 1.4606093343522966 1.2637968958131551 0.006576182042218326 0.29515846248974226 0.7698290927762043 48.26607747682098 0.11581643055241385 0.0896530657286198 7.103607404407666e-08 7.148521048751254 -0.19681243853914143 SVAPLPPQRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SVAPLPPQRSPR 12 1 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 SVAPLPPQRS(1)PR 113.54 0.028275 0.0 2454.7 3062.6 2924.6 3403.4 2878.3 2556.0 2707.5 2543.7 1928.9 2339.1 True False 2511.8897339852606 2704.0293682358856 2527.4553836778746 2809.0600797303937 2617.958273205137 2530.2889606623166 2503.271095179245 2476.2328128979284 3273.202418718019 2639.346269763443 0.9517090511243884 1.0245072422718675 0.9576065909322322 1.0643014567323754 0.9918964795171712 0.9586801813954858 0.9484436066070276 0.9381992962673541 1.2401564948927246 1.0 11.36596492251802 -8.239787096113272 24.999140441279724 1.120078302881777 0.9817155728904149 0.4259532520639241 0.06527307693770583 620.5358389108429 716456.6759027148 0.04150431509654419 0.015655068202628693 5.757221040214731e-09 8.239787096113272 -0.138362729991362 SVAPLPPQRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SVAPLPPQRSPR 12 1 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 SVAPLPPQRS(1)PR;SVAPLPPQRS(1)PR 109.1 0.0042786000000000005 13858800.0 280810.0 247830.0 278920.0 257410.0 266360.0 202505.0 283870.0 388970.0 239361.0 338360.0 True False 265203.7043714953 266837.7641009516 260974.59086513464 222350.3139429818 232897.4755113871 230398.22559263796 297070.5174777339 390101.83830254996 287239.888305136 328590.6676351413 0.8070944506128541 0.812067384692865 0.7942239892062735 0.6766787247587747 0.7087769022399337 0.7011709348010646 0.9040747249936917 1.1871969496580745 0.874157170598892 1.0 18.325931981055618 -7.489108451688314 5.1401594207159755 1.0282875530895064 0.7520251383932588 0.6844227680470772 0.0829651390954802 0.10501037401737803 7.2792106966143875 0.03672948331224588 0.023215086511016437 3.2425863361835496e-08 7.489108451688314 -0.27626241469624757 SVAS(ph)NQSEMEFSSLQDMPK ddPTM_A459_Selumetinib_30min_R1 1 SVASNQSEMEFSSLQDMPK 19 0 Q8N163-2;Q8N163;G3V119;H0YB24;A0A087X2B6 Q8N163-2 CCAR2 Cell cycle and apoptosis regulator protein 2 1 S(0.19)VAS(0.717)NQS(0.094)EMEFSSLQDMPK 113.65 0.0003452 4994800.0 2588.7 2688.3 3787.7 3743.6 3466.9 2717.5 2171.2 2239.5 1212.4 2191.7 True False 2649.011673266649 2373.552586243235 3273.3511443468137 3089.85053607531 3153.3195071309083 2690.1644172925835 2007.4246359568506 2180.101185078787 2057.3542498075194 2473.0260439658596 1.071162060638298 0.9597766234749779 1.3236217840623772 1.24942094468212 1.2750854423166924 1.087802703839912 0.8117280611964972 0.881552052554479 0.8319177449940036 1.0 11.272061717799781 -7.112618191594532 4.34464682075384 0.873056345850139 1.1767159081646983 0.6219433824495841 0.10834857505223873 0.16237791630038056 5.0557561198933145 0.04590784275205902 0.03535712142365571 7.715815040322286e-08 7.112618191594532 0.30365956231455926 SVAS(ph)NQSEMEFSSLQDMPK ddPTM_A459_Selumetinib_30min_R2 2 SVASNQSEMEFSSLQDMPK 19 0 Q8N163-2;Q8N163;G3V119;H0YB24;A0A087X2B6 Q8N163-2 CCAR2 Cell cycle and apoptosis regulator protein 2 1 S(0.457)VAS(0.499)NQS(0.043)EMEFSSLQDMPK;S(0.065)VAS(0.924)NQS(0.011)EMEFSSLQDMPK 137.9 0.00013152 2278400.0 78098.0 71189.0 93682.0 86625.0 94063.0 44981.0 56302.0 62565.0 52240.0 70313.0 True False 73757.62581106457 76648.96739128698 87654.60211324954 74826.52556354004 82245.9650061107 51176.724453136645 58920.15456029651 62747.05379180669 62689.459707555885 68282.8809948862 1.0801774139639535 1.1225209931758344 1.2836980636451778 1.095831407130345 1.2044887943768836 0.749481036937638 0.8628832542187129 0.9189280369776123 0.9180845739688515 1.0 16.059236309463877 -6.749933909762444 24.999988529803748 0.8831213693078357 1.159011179915575 0.7374510633357818 0.07974182329298338 109.83739562250362 238662.98738177307 0.026362710843713354 0.026143378602785188 1.7785500463387855e-07 6.749933909762444 0.2758898106077392 SVAS(ph)SQPAKPTK ddPTM_A459_Selumetinib_30min_R1 2 SVASSQPAKPTK 12 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 SVAS(0.963)S(0.031)QPAKPT(0.006)K;SVAS(0.998)S(0.002)QPAKPTK 206.46 4.8934e-05 78908000.0 6196.3 5333.700000000001 6976.9 6721.4 6494.9 4552.2 5307.0 5274.200000000001 2639.8 4476.5 True False 6340.661734099023 4709.2279244301435 6029.475301368447 5547.633666304248 5907.437441767727 4506.4090010669 4906.688717309785 5134.3110829839425 4479.547796636332 5051.102379802512 1.2553025572106757 0.932316862802188 1.1936949299380837 1.0983015684827893 1.1695342912448938 0.8921634649668478 0.9714094762620169 1.0164733749040906 0.8868455754427758 1.0 12.30238256843011 -6.758382440234725 24.999956099510413 0.9555349027973328 1.1206535640967372 0.5028972651755524 0.08746535877594615 70.00452883040403 572504.3533467219 0.027925236083895088 0.0267875290222327 1.7442854565741816e-07 6.758382440234725 0.16511866129940445 SVAS(ph)SQPAKPTK ddPTM_A459_Selumetinib_30min_R2 2 SVASSQPAKPTK 12 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 S(0.007)VAS(0.858)S(0.134)QPAKPTK;S(0.004)VAS(0.973)S(0.002)QPAKPT(0.021)K 71.176 0.033566000000000006 184537000.0 120934.0 89261.0 112848.0 127489.0 124431.0 86445.0 103470.0 91608.0 85726.0 111814.0 True False 114212.97241715918 96107.03168064791 105587.48253961217 110124.77826920824 108798.86535274595 98352.01408042051 108281.56002191534 91874.56411347912 102873.59538457004 108585.63929233872 1.0518239166937198 0.8850804978170697 0.9723890122831549 1.0141744247848998 1.001963667219688 0.9057552612057032 0.9971996364122817 0.8461023456898443 0.947395954520372 1.0 16.728473790362912 -6.756982661977973 24.991946408428767 0.9332913485425977 0.9804410267567277 0.13073225923731902 0.05740084085961369 233.55487426072614 1309708.5822216691 0.018884507599772504 0.018266545800471233 1.749916547872938e-07 6.756982661977973 0.047149678214130075 SVASNQS(ph)EMEFSSLQDMPK ddPTM_A459_Selumetinib_30min_R2 1 SVASNQSEMEFSSLQDMPK 19 0 Q8N163-2;Q8N163;G3V119;H0YB24;A0A087X2B6 Q8N163-2 CCAR2 Cell cycle and apoptosis regulator protein 2 1 S(0.306)VAS(0.268)NQS(0.424)EMEFS(0.001)SLQDMPK 67.194 0.014007 2482000.0 20536.0 19690.0 29774.0 23526.0 27591.0 14061.0 15506.0 17739.0 14348.0 21560.0 True False 19394.69133212147 21200.159686671224 27858.3732554801 20321.71821538634 24124.771913330416 15997.775116950595 16227.059724556098 17790.61755315046 17218.000916615845 20937.50678039263 0.9263133158855399 1.0125446123568334 1.3305487395265545 0.9705892123897504 1.152227539141507 0.7640725939695958 0.7750234970551638 0.8497008617000598 0.82235201627445 1.0 14.353802037209 -6.762104774114857 24.999972578942614 0.8286356865085276 1.0827973924372787 0.4883076266449434 0.12046010046034365 14.76406952997276 554696.2237777157 0.04097617407944417 0.03830190419682039 1.7293990890792365e-07 6.762104774114857 0.2541617059287511 SVAVS(ph)DEEEVEEEAER ddPTM_A459_Selumetinib_30min_R1 1 SVAVSDEEEVEEEAER 16 0 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(0.049)VAVS(0.951)DEEEVEEEAER 208.38 6.3284e-08 10382000.0 1450.6 1444.4 1593.3 1517.3 1546.0 1166.5 1129.1 1344.8 650.04 985.94 True False 1484.396157623751 1275.2889765166583 1376.9386113704304 1252.3320382484949 1406.1645729684697 1154.766069097257 1043.931077956375 1309.1315354739693 1103.0704029568462 1112.495002868868 1.3342946743992878 1.1463323190018673 1.2377031877173592 1.1256967761823824 1.2639738329990657 1.0379966346989262 0.9383692288633366 1.1767527333588206 0.9915284114645748 1.0 10.119583140424274 -6.772499727722528 24.824205338800546 1.034316381459476 1.2129852550938076 0.5962063562667295 0.0790598676051392 146.75058898009564 329369.8515640445 0.026628665500005175 0.023706260014989003 1.6884969180761365e-07 6.772499727722528 0.1786688736343316 SVAVS(ph)DEEEVEEEAER ddPTM_A459_Selumetinib_30min_R2 1 SVAVSDEEEVEEEAER 16 0 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(0.173)VAVS(0.827)DEEEVEEEAER 137.27 0.00040769 15419000.0 18895.0 14303.0 21424.0 24075.0 27473.0 15699.0 13528.0 13481.0 12939.0 14068.0 True False 17844.891542678 15399.99410860632 20045.603164687513 20795.943468308524 24021.596128263805 17861.394748667055 14157.078805223464 13520.227478100314 15527.161545866496 13661.820286946357 1.3061869624890687 1.1272285672884133 1.4672717649375577 1.5221941901972391 1.7583012822395303 1.307394942512406 1.036251283348407 0.9896358753173373 1.1365368025447122 1.0 13.73786209919444 -7.155626475033674 4.1018163936921 1.039744635459357 1.4333782025091606 0.5889136324275952 0.1554416917112189 0.18883842853394048 5.513182936214255 0.06938759377210497 0.05267915263350858 6.988331932533802e-08 7.155626475033674 0.3936335670498037 SVAVS(ph)DEEEVEEEAERR ddPTM_A459_Selumetinib_30min_R2 2 SVAVSDEEEVEEEAERR 17 1 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 S(0.079)VAVS(0.921)DEEEVEEEAERR;S(0.038)VAVS(0.962)DEEEVEEEAERR 64.249 0.023699 11233000.0 32742.0 26703.0 28285.0 29744.0 27464.0 26274.0 27807.0 22257.3 22432.1 27804.0 True False 30922.33071661092 28751.034236322084 26465.173894379484 25692.81588873806 24013.726788724805 29893.00500837493 29100.08059852517 22322.065058105625 26919.146805242424 27001.226276532307 1.145219494845187 1.064804758934619 0.9801471097400223 0.9515425568307825 0.8893568959716456 1.1070980518524067 1.0777318148626847 0.8267056032750075 0.9969601576443504 1.0 14.72073730915511 -4.996269908421405 2.269873073826762 0.9759922931518429 1.153781038701502 0.32619084982330526 0.07685815370939364 0.4921423234192489 4.134588312324658 0.0216533813072753 0.14718219061745405 1.0086258432893667e-05 4.996269908421405 0.17778874554965907 SVCPGGS(ph)SPGSSSGGGR ddPTM_A459_Selumetinib_30min_R1 3 SVCPGGSSPGSSSGGGR 17 0 Q53LP3 Q53LP3 SOWAHC Ankyrin repeat domain-containing protein SOWAHC 1 S(0.001)VCPGGS(0.497)S(0.497)PGS(0.002)S(0.002)S(0.001)GGGR;SVCPGGS(0.5)S(0.5)PGSSSGGGR;SVCPGGS(0.497)S(0.497)PGS(0.007)SSGGGR 301.75 2.951099999999999e-89 33934000.0 5538.87 6079.73 6868.200000000001 6421.33 6136.889999999999 5250.97 5857.51 5725.71 3148.08 4678.71 True False 5667.914894235118 5367.912385210205 5935.53616432209 5299.965258792731 5581.80938305593 5198.1500092992965 5415.673304791647 5573.845571072764 5342.061833333932 5279.268002994705 1.0736175717959289 1.0167910365916668 1.1243104462503348 1.0039204783288678 1.0573074486632628 0.9846346134256883 1.0258379195220937 1.0557989418061287 1.0118944198899555 1.0 12.36612219120428 SVCPGGS(ph)SPGSSSGGGR ddPTM_A459_Selumetinib_30min_R2 2 SVCPGGSSPGSSSGGGR 17 0 Q53LP3 Q53LP3 SOWAHC Ankyrin repeat domain-containing protein SOWAHC 1 SVCPGGS(0.5)S(0.5)PGSSSGGGR;SVCPGGS(0.5)S(0.5)PGSSSGGGR 272.96 7.676199999999998e-52 33775000.0 44703.0 43138.0 48722.0 48409.0 48829.0 36534.0 41096.0 39723.0 36094.0 46853.0 True False 42218.58622028764 46446.54588946789 45587.279564502656 41815.610689817135 42694.66448320142 41566.22687736811 43007.04543017914 39838.58735350335 43313.808550622525 45500.23215128647 0.9278762815959379 1.0207979980197674 1.0019131201996234 0.919019721718823 0.9383394867358775 0.9135387867728246 0.9452049670248366 0.8755688810782685 0.9519469792287174 1.0 15.473586285798262 -5.764061036978973 24.99991406189807 0.929312853958023 0.9872560247981348 0.2533168443708762 0.03735244489590446 74.24794165857215 708034.8298488063 0.009835299623746026 0.015379023083122677 1.7216265956946074e-06 5.764061036978973 0.0579431708401118 SVDISLGDS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SVDISLGDSPR 11 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 SVDISLGDS(1)PR 92.792 0.024509 8746200.0 2726.3 3179.5 2775.1 2865.5 3284.3 3047.9 2976.6 2588.2 1868.6 3006.4 True False 2789.817485543659 2807.2426618905533 2398.2566625331565 2365.0942170968583 2987.235644890261 3017.240893271781 2752.0726655255926 2519.5525283415554 3170.8777228557665 3392.300724815876 0.8223968662728397 0.8275335501226596 0.7069705362467023 0.6971947386018462 0.8805928150878779 0.889437917811826 0.8112702524847548 0.7427267606053143 0.9347277791911778 1.0 11.728048354023562 -6.2803005643969385 24.535840476048154 0.8609850811650377 0.7640565066876126 0.3362897218125399 0.07587884916373477 894.3661905439385 1163446.137920302 0.024115125744020097 0.027394947727220186 5.24444379728291e-07 6.2803005643969385 -0.09692857447742509 SVDISLGDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SVDISLGDSPR 11 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 SVDISLGDS(0.999)PR 100.02 0.016677 12930000.0 111950.0 87313.0 102220.0 119060.0 116880.0 82610.0 112560.0 106220.0 84061.0 104940.0 True False 105728.26717135769 94009.62634445513 95643.27648872092 102843.8226100439 102196.48947954261 93988.77764108437 117794.2630334087 106529.0826143325 100875.548860583 101910.10953313543 1.0374659359676266 0.9224759621506293 0.9385062672081921 1.009162124162028 1.002810123036067 0.9222713828064771 1.1558643550972598 1.0453239929027378 0.9898483018290148 1.0 16.636937649099302 -7.232057498265984 24.997834980610968 1.0515362262904513 0.9714104522828518 0.3127092655694653 0.05481853623281596 826.8086009375673 703442.0425968177 0.020886903317079247 0.016176241280546604 5.860605680935999e-08 7.232057498265984 -0.08012577400759946 SVDISLGDS(ph)PRR ddPTM_A459_Selumetinib_30min_R1 3 SVDISLGDSPRR 12 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 SVDISLGDS(1)PRR;SVDISLGDS(1)PRR;SVDISLGDS(1)PRR 97.2 0.0084295 6293200.0 11593.3 14194.699999999999 13014.400000000001 12611.4 10178.2 13117.2 11137.8 10671.4 6559.7 9201.3 True False 11863.401333365107 12532.777925063 11247.115962982065 10409.05573529761 9257.583607107166 12985.25287746468 10297.666778905772 10388.359806407574 11131.331798467825 10382.37648325184 1.1426479623911112 1.2071203491108267 1.0832891661292734 1.002569667174833 0.8916632547510567 1.2507014071789466 0.9918410101499674 1.0005762961076767 1.0721371755709446 1.0 13.341849088002741 -5.455713707885614 4.216096670715887 1.0321536479347149 1.173010906245241 0.3023024296395387 0.08711128556725488 0.2722513264060513 9.341683502544262 0.02341267608002666 0.05012867756326864 3.5017593111886283e-06 5.455713707885614 0.1408572583105261 SVDISLGDS(ph)PRR ddPTM_A459_Selumetinib_30min_R2 4 SVDISLGDSPRR 12 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 SVDISLGDS(1)PRR;SVDISLGDS(1)PRR;SVDISLGDS(1)PRR;SVDISLGDS(1)PRR 128.71 0.0012387 24262900.0 81715.6 83490.9 95562.1 90750.1 91089.1 58303.8 60311.0 67965.5 57655.9 68359.5 True False 77174.17408546484 89894.38356444369 89413.73852614731 78389.77982734577 79645.67291111393 66334.61922079965 63115.58100397926 68163.26835270571 69188.69104044554 66385.7836156887 1.162510553949785 1.3541209980264401 1.3468808177932916 1.1808217898149538 1.1997398926882827 0.9992292868728454 0.9507394138684746 1.0267750810520964 1.0422215009313294 1.0 16.01858670390679 -6.550268590384741 1.8185708049502054 0.9989625533558433 1.2812698244431244 0.793273408579971 0.06269366299026358 0.1511827625346673 1.014518251962963 0.024499169171152448 0.026147145497632904 2.8166404349758876e-07 6.550268590384741 0.28230727108728115 SVDQGGGGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SVDQGGGGSPR 11 0 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 SVDQGGGGS(1)PR 103.11 0.013616 1830100.0 1097.3 1415.3 1284.6 1436.7 1119.1 1211.2 1010.4 1242.9 1005.5 1050.9 True False 1122.8649550258801 1249.5960180448803 1110.1583758027082 1185.8073151991118 1017.8776025931522 1199.0164276816101 934.1847145222929 1209.9342544918165 1706.2600611856328 1185.7932516328517 0.946931476865534 1.0538059786764442 0.9362157983898176 1.0000118600491619 0.8583938230307201 1.011151333531836 0.7878141600451084 1.0203585260969585 1.438918680668904 1.0 10.211636776126726 -8.01736143150735 24.616329577905923 1.2228525152801581 0.9446687375007077 0.4477627423224141 0.12159969452968143 490.300881999048 695180.6725839392 0.07218136037638256 0.02865592193618451 9.608123317881274e-09 8.01736143150735 -0.27818377777945047 SVDQGGGGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SVDQGGGGSPR 11 0 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 S(0.002)VDQGGGGS(0.998)PR;SVDQGGGGS(1)PR 154.23 0.00054657 28022000.0 18606.0 14946.8 19969.4 17409.6 19306.3 21870.7 41191.0 123619.0 35369.0 63166.0 True False 17571.953005719322 16093.171498463056 18684.590545038776 15038.382446764868 16880.86999348813 24883.190402552544 43106.46311841808 123978.71082377285 42443.78829243001 61342.233455022346 0.2864576657223203 0.2623505958625222 0.3045958631215928 0.2451554434807364 0.2751916427344564 0.40564532787671514 0.7027207959427303 2.0210987412885304 0.6919178827023122 1.0 15.90459307526792 -7.529974567692953 24.852592729480786 1.2862872032379642 0.3139103368698211 0.6405536656620847 0.3151703896421485 92.46369566219296 323841.11979263014 0.13791587260000263 0.07985062932839326 2.9513820546898252e-08 7.529974567692953 -0.9723768663681431 SVEAAAELS(ph)AK ddPTM_A459_Selumetinib_30min_R1 1 SVEAAAELSAK 11 0 P20962;F5H7R9;F5GXR3 P20962 PTMS Parathymosin 1 SVEAAAELS(1)AK 86.288 0.033676 4537400.0 2045.3 2443.8 2771.5 3313.3 2355.3 2571.0 2541.3 2396.2 1486.5 2475.2 True False 2092.951510538988 2157.678759908203 2395.1455227597735 2734.694353343925 2142.263530861988 2545.1380742812257 2349.6076949876315 2332.644992045451 2522.4819303355966 2792.9160304897086 0.7493786020383902 0.7725541105974019 0.8575787802470416 0.9791538032256647 0.7670347076229014 0.9112834208033681 0.8412740194611766 0.8352005454444136 0.9031714175428703 1.0 11.447556484052543 -12.889596831734307 0.02218772236821641 2.024238667672773 1.4695844224429638e-06 0.4228367632681107 0.0625376365089356 2193.80840488227 4.8878665306094025 285.8112350639717 172.55672605019484 1.2894460266939596e-13 12.889596831734307 -2.0242371980883505 SVEAAAELS(ph)AK ddPTM_A459_Selumetinib_30min_R2 2 SVEAAAELSAK 11 0 P20962;F5H7R9;F5GXR3 P20962 PTMS Parathymosin 1 SVEAAAELS(1)AK;SVEAAAELS(1)AK 128.31 0.0028002 3347100.0 46913.0 43236.0 48566.0 45613.0 43350.0 31600.0 35105.0 31397.0 29253.0 36499.0 True False 44305.763267618546 46552.062174348255 45441.316434662716 39400.43071318617 37903.9854460829 35952.61316376066 36737.45205923784 31488.360071946838 35104.41739711202 35445.179034209206 1.2499799542515422 1.3133538450862234 1.2820168404511636 1.1115878600912026 1.06936927612922 1.014316026703144 1.0364583579555748 0.8883679228014754 0.9903862345632869 1.0 15.113301796678245 -6.097393908860056 1.0803039720610894 0.9731844007259217 1.3045349278693652 0.895031509716449 0.043492237699192 0.15210357959357407 0.3651789122938933 0.018283703062610474 0.03331927372910109 7.991091273021122e-07 6.097393908860056 0.3313505271434435 SVEAAAELSAK ddPTM_A459_Selumetinib_30min_R2 2 SVEAAAELSAK 11 0 P20962;F5H7R9;F5GXR3 P20962 PTMS Parathymosin 0 ; 211.78 0.00026806 4983500.0 39222.0 36863.0 45391.0 38352.0 42616.0 28798.0 31497.0 33098.0 24173.0 39235.0 False True 37042.1982581062 39690.273566773045 42470.59247798408 33128.3914391098 37262.19708812616 32764.66309778415 32961.672910121466 33194.30970033113 29008.27545005261 38102.1836052275 0.9721804566871102 1.041679762451401 1.114649829994448 0.8694617553248231 0.9779543732767563 0.8599156268117121 0.8650861916900539 0.8711917942618115 0.7613284254415478 1.0 15.217586059319526 -6.150819567958521 1.315251138832082 0.8660767052493406 1.0374877799803677 0.4149161203513908 0.07654195770977616 0.39409603657507164 1.3813397236242357 0.028259283795098376 0.044666721948293374 7.066110620113378e-07 6.150819567958521 0.17141107473102712 SVEDEMDS(ph)PGEEPFYTGQGR ddPTM_A459_Selumetinib_30min_R1 3 SVEDEMDSPGEEPFYTGQGR 20 0 A0A590UJA3;S4R3W2;A0A590UJU2;A0A590UK38;B1AKN5;A0A590UK09;B1AKN8;Q12857-2;Q12857-3;Q12857;Q12857-4;A0A590UK73;B1AKN7 A0A590UJA3 NFIA Nuclear factor 1;Nuclear factor 1 A-type 1 SVEDEMDS(1)PGEEPFYTGQGR;SVEDEMDS(1)PGEEPFYTGQGR;SVEDEMDS(1)PGEEPFYTGQGR 352.06 1.303399999999999e-194 29046000.0 2434.7 2869.03 2412.3 2771.78 2741.0600000000004 2328.3199999999997 2414.2799999999997 2101.74 1198.09 2131.67 True False 2491.423772898487 2533.1226338241404 2084.7229098154057 2287.7406557545746 2493.13160697345 2304.899214745416 2232.16891585202 2045.995027786332 2033.0712249685669 2405.2906087241417 1.0358098783830674 1.0531461872575163 0.866723921946888 0.9511285860663963 1.0365199107046372 0.9582622600302019 0.9280246252805384 0.8506227980791087 0.8452497247503019 1.0 11.231995496510429 -7.353081256921975 2.7245287409757712 0.8869141193090396 0.9835424658821013 0.2602226145681641 0.06451290175304894 0.36738938004635024 5.311438819715932 0.031874481406542594 0.020038613577095864 4.4352565208481e-08 7.353081256921975 0.09662834657306163 SVEDEMDS(ph)PGEEPFYTGQGR ddPTM_A459_Selumetinib_30min_R2 3 SVEDEMDSPGEEPFYTGQGR 20 0 A0A590UJA3;S4R3W2;A0A590UJU2;A0A590UK38;B1AKN5;A0A590UK09;B1AKN8;Q12857-2;Q12857-3;Q12857;Q12857-4;A0A590UK73;B1AKN7 A0A590UJA3 NFIA Nuclear factor 1;Nuclear factor 1 A-type 1 SVEDEMDS(1)PGEEPFYTGQGR;SVEDEMDS(1)PGEEPFYTGQGR;SVEDEMDS(1)PGEEPFYTGQGR 189.44 1.4112e-15 25204700.0 61699.6 49251.5 66851.0 59080.4 66631.4 54615.6 53092.7 55842.9 52796.9 53034.7 True False 58270.58323506827 53028.93168146711 62549.879441865414 51033.54760062534 58260.56783972617 62138.40314894578 55561.61575118922 56005.39359371025 63357.755268641966 51503.450410300975 1.1313918343500697 1.0296190111344663 1.2144793978571016 0.9908762848715539 1.1311973736826326 1.2064901021955172 1.0787940479435645 1.087410516141048 1.2301652561897107 1.0 15.652381466662446 SVEDVRPHHT(ph)DANNQSACFEAPDQK ddPTM_A459_Selumetinib_30min_R1 1 SVEDVRPHHTDANNQSACFEAPDQK 25 1 E7EPN9;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7;Q9Y520-2;Q9Y520-3 E7EPN9 PRRC2C Protein PRRC2C 1 S(0.389)VEDVRPHHT(0.581)DANNQS(0.03)ACFEAPDQK 55.228 0.018338 4339000.0 399.28 415.23 389.24 446.9 492.98 546.1 689.86 318.88 0.0 279.72 True False 408.58244713636503 366.61467856481005 336.3833459422746 368.85730435197536 448.39004604268797 540.6067298191277 637.8233047905273 310.42226653178113 0.0 315.62478670353147 1.294519519216814 1.1615522418053108 1.0657697370841848 1.1686575956356862 1.420642690093487 1.7128145589114436 2.020827677864347 0.9835167566334482 0.0 1.0 8.302066697566167 -8.002889640728593 24.990586471971096 0.49725266205958507 1.3952905118328773 0.5204288554942573 0.34892848647802926 85.89592304393095 742851.3855098743 0.20502078223991024 0.09557775624272646 9.933684428089216e-09 8.002889640728593 0.8980378497732923 SVEST(ph)SPEPSK ddPTM_A459_Selumetinib_30min_R1 4 SVESTSPEPSK 11 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;P18583-8 P18583-10 SON Protein SON 1 SVES(0.001)T(0.5)S(0.5)PEPSK;SVES(0.001)T(0.5)S(0.5)PEPSK;SVES(0.002)T(0.93)S(0.069)PEPSK;SVES(0.002)T(0.499)S(0.499)PEPSK 222.2 1.9264e-05 520974000.0 35628.1 38725.3 41790.5 43624.8 37882.9 33055.0 37162.3 34048.5 20006.6 30498.6 True False 36458.16540978543 34191.32387309646 36115.57963878487 36006.54761891711 34456.398383769214 32722.496711538646 34359.117791460616 33145.42317488506 33949.73897574987 34413.39239152126 1.0594179438923308 0.9935470320421095 1.049462930823495 1.0462946288256187 1.0012496876727142 0.9508651846715579 0.9984228639989002 0.9631547741004284 0.9865269482736139 1.0 15.070682496128494 -6.4709947261996135 4.7812634609401155 0.97827734865653 1.0343662784710994 0.611609565868535 0.021480177984200446 0.1398878148427474 6.913851229801267 0.006591863466775412 0.007307293304924374 3.3806894147870166e-07 6.4709947261996135 0.056088929814569366 SVEST(ph)SPEPSK ddPTM_A459_Selumetinib_30min_R2 3 SVESTSPEPSK 11 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;P18583-8 P18583-10 SON Protein SON 1 SVES(0.001)T(0.499)S(0.499)PEPSK;SVES(0.002)T(0.993)S(0.005)PEPSK;SVES(0.001)T(0.995)S(0.004)PEPSK 219.92 2.9928e-05 332093000.0 643934.0 554116.0 560228.0 670595.0 651378.0 450538.0 497244.0 531385.0 415920.0 525867.0 True False 608146.7261520408 596614.9154362362 524183.5404101271 579258.8041591009 569546.0722467955 512595.51992324105 520366.83127029316 532931.2423744772 499115.62177577784 510683.85334344767 1.1908477665203308 1.1682666517263034 1.0264345288739736 1.134280632463104 1.1152615625459408 1.0037433464310213 1.018960806893445 1.043563917060185 0.9773475674001976 1.0 18.962070919487545 -1.5228787452805659 0.23302269080540386 0.9826728957245329 2.2078016015476525 0.6891060884094409 0.04077269337150476 29.89092761532934 0.39379965319696353 0.06025479727471644 14.026133763872199 0.029999999999984227 1.5228787452805659 1.2251287058231197 SVESTS(ph)PEPSK ddPTM_A459_Selumetinib_30min_R2 2 SVESTSPEPSK 11 0 P18583-10;P18583-3;P18583-4;P18583-7;P18583;P18583-5;P18583-9;P18583-2;P18583-6;P18583-8 P18583-10 SON Protein SON 1 SVEST(0.29)S(0.709)PEPSK;SVES(0.036)T(0.192)S(0.768)PEPS(0.003)K 107.09 0.010744 75581000.0 201246.0 174081.0 208550.0 211232.0 212145.0 167554.0 178227.0 185346.0 157816.0 198414.0 True False 190061.5529715681 187432.4529413614 195132.1200520717 182461.8372044751 185493.448499637 190633.04259622647 186514.9086501007 185885.32617431795 189383.60974746634 192685.2722785171 0.9863833946625845 0.9727388643924845 1.012698675641477 0.9469423119206302 0.9626757992770475 0.9893493173711573 0.9679769836300853 0.9647095700476258 0.9828649979730761 1.0 17.555886779216543 -5.758974907388166 24.999975944243413 0.9720111941538802 0.9888201579410524 0.17274363887132005 0.016797937594712396 115.70740494126709 1173726.9562452186 0.004519573532425317 0.007386568082486439 1.7419075141969747e-06 5.758974907388166 0.016808963787172226 SVFGT(ph)PTLETANK ddPTM_A459_Selumetinib_30min_R1 1 SVFGTPTLETANK 13 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 S(0.038)VFGT(0.955)PT(0.007)LETANK 198.23 0.00036316 31037000.0 3547.2 3746.7 3537.8 3463.6 3391.3 3114.5 3528.4 3523.2 1953.4 3252.9 True False 3629.842858350317 3308.0346222064254 3057.386191744369 2858.747279824349 3084.5575137826468 3083.170957739741 3262.2499472688646 3429.753291033524 3314.777129308817 3670.4414009292072 0.9889390571475647 0.9012634342477079 0.8329750724178194 0.7788565372820364 0.8403778120532756 0.8400000493017561 0.8887895462499401 0.9344252955966683 0.9031004087055169 1.0 11.841737854171836 -8.400934429478555 0.9123880360109825 0.9940343927202075 0.8606734035071179 0.3446776241118007 0.05413620995621513 0.6759378968261311 1.2389948457482831 0.056148374521455525 0.019780284993037113 3.972515226541905e-09 8.400934429478555 -0.1333609892130897 SVFGT(ph)PTLETANK ddPTM_A459_Selumetinib_30min_R2 1 SVFGTPTLETANK 13 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 S(0.371)VFGT(0.625)PT(0.004)LETANK 185.32 0.000294 6726000.0 35833.0 41130.0 37844.0 41817.0 46471.0 39731.0 37656.0 37385.0 36610.0 47279.0 True False 33841.54531086428 44284.538746205544 35409.15824143177 36121.45246165139 40632.8975239889 45203.5846078916 39407.078613948455 37493.7841605801 43933.02296886715 45913.932424405524 0.737064841191338 0.9645119990346573 0.7712072648042242 0.7867209483989015 0.8849796865230063 0.9845287088470701 0.8582814961195013 0.8166101699590057 0.9568560271155206 1.0 15.486644380456827 -6.447842188408967 6.2452712812312345 0.9105679118557871 0.8232832345067735 0.2995825778834852 0.0765685112085011 0.3660533446974268 24.453376406824226 0.02384813881175754 0.026899298399500747 3.565806822562899e-07 6.447842188408967 -0.08728467734901357 SVFWASS(ph)PYR ddPTM_A459_Selumetinib_30min_R1 2 SVFWASSPYR 10 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3 O15027 SEC16A Protein transport protein Sec16A 1 SVFWAS(0.003)S(0.997)PYR;SVFWAS(0.004)S(0.996)PYR 141.1 0.0013462 41983000.0 3504.2 4293.9 4649.7 4731.3 3827.3 3627.3999999999996 3492.3 3849.7 2450.5 3123.8 True False 3585.8410420137516 3791.1681918200456 4018.2962789738845 3905.067272500564 3481.121390764695 3590.9116494156806 3228.8729993331394 3747.5934504120582 4158.319522561305 3524.770158388718 1.0173262030943178 1.0755788381824891 1.1400165396346786 1.107892741093136 0.987616563445948 1.0187647670783726 0.9160520698487636 1.0632164033427927 1.179742035850134 1.0 11.783313470637722 -6.251479486117316 24.774750304597475 1.0247104374776956 1.088431311318591 0.14205603511815723 0.06899780201364195 1246.3813122551383 3100309.1814532145 0.021730981585057995 0.02768076814968876 5.604288885753931e-07 6.251479486117316 0.06372087384089542 SVFWASS(ph)PYR ddPTM_A459_Selumetinib_30min_R2 2 SVFWASSPYR 10 0 O15027;O15027-5;F1T0I1;O15027-2;O15027-4;O15027-3 O15027 SEC16A Protein transport protein Sec16A 1 SVFWAS(0.002)S(0.998)PYR;SVFWAS(0.162)S(0.838)PYR 133.91 0.0021906 19195200.0 178602.0 182373.0 186870.0 207930.0 221570.0 214130.0 200450.0 165884.0 153879.0 173065.0 True False 168676.0158404538 196360.4226783797 174846.98764867234 179609.57530074305 193734.39573906784 243624.46382139483 209771.32218413957 166366.69497642553 184659.09973849525 168068.16377312873 1.0036166996394724 1.1683380020944478 1.0403337772208554 1.0686710157861532 1.152713228905061 1.449557479251441 1.2481324093437764 0.9898763170935813 1.0987155187091961 1.0 17.358686943112716 -4.755100402043587 24.349581906709567 1.1436967979112906 1.0036163757919914 0.08162323090749268 0.12953441757613332 435.52926774073757 1672751.7819835872 0.03489772794505946 0.315419933754642 1.7575172566819385e-05 4.755100402043587 -0.14008042211929927 SVGDDEELQQNESGT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 SVGDDEELQQNESGTSPK 18 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 SVGDDEELQQNESGT(0.707)S(0.293)PK 216.16 8.759e-14 4449400.0 34386.0 35649.0 29521.0 30256.0 30771.0 19258.0 22903.0 21897.0 16061.0 15653.0 True False 32474.96377806434 38383.16367039831 27621.651000034522 26135.080605488794 26905.271883769714 21910.614693281732 23968.03488143354 21960.716644756503 19273.64878183489 15201.057218621787 2.1363621826435506 2.5250325104610285 1.817087496137907 1.7192936142278628 1.7699605689800237 1.441387554705111 1.576734732112706 1.4446835064770307 1.2679150209515722 1.0 13.891884044732912 -1.5228787452803378 0.15970855713070253 0.8873504754137547 6.749489503799501 0.8486590178008744 0.16063193440254578 22.14091864212508 0.22900917386975642 0.47547178540701834 30.509546847637736 0.02999999999999998 1.5228787452803378 5.862139028385746 up SVGDES(ph)WEQTQEGDVGALYHEQLALK ddPTM_A459_Selumetinib_30min_R1 2 SVGDESWEQTQEGDVGALYHEQLALK 26 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 1 S(0.001)VGDES(0.989)WEQT(0.01)QEGDVGALYHEQLALK;S(0.001)VGDES(0.995)WEQT(0.004)QEGDVGALYHEQLALK 188.26 1.0619e-27 18357000.0 3965.1000000000004 5347.7 4417.7 4759.9 4209.3 4427.0199999999995 4452.0 4585.2 1910.3600000000001 3710.12 True False 4057.479115258469 4721.5887979217205 3817.8006046891032 3928.672819389053 3828.5695582122767 4382.48819821255 4116.18205567424 4463.585601171356 3241.7413928260416 4186.350041629152 0.9692163997063821 1.1278533211437514 0.9119640179929568 0.9384482378019633 0.9145364148102527 1.046851829071386 0.9832388631487667 1.0662236929032136 0.7743598506073543 1.0 12.031477232234918 -5.274533962207411 24.960579059767436 0.9591488495420872 1.0485348706867312 0.1611888798277421 0.08531177574800318 1221.3580189470485 2328125.012185198 0.021505056780631217 0.045253055550399914 5.314544376808572e-06 5.274533962207411 0.089386021144644 SVGDGETVEFDVVEGEK ddPTM_A459_Selumetinib_30min_R2 2 SVGDGETVEFDVVEGEK 17 0 H0Y449;P67809;A0A0D9SEI8;Q9Y2T7;P16989-2;P16989;P16989-3 H0Y449;P16989-2 YBX1;YBX3;YBX2 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 ; 272.77 1.1184e-50 7566700.0 36549.0 30450.0 33911.0 37009.0 34965.0 24757.0 30091.0 30941.0 27810.0 31047.0 False True 34517.75289723936 32785.41708781813 31729.20317950515 31968.310355914025 30572.384108933995 28167.052028329825 31490.291124185344 31031.03318744172 33372.77707632328 30150.592440206423 1.1448449301848294 1.0873888184067029 1.0523575363379467 1.0602879667891247 1.013989498533538 0.9342122243265938 1.0444335774375169 1.0292014410324226 1.1068696955957658 1.0 14.879898730004843 -4.842248643370658 1.0049679795373143 1.0230119333650862 1.1975146976065938 0.45642538119401155 0.041271872724132734 1.7121238136076533 1.4838054034222696 0.014534114987114776 0.31712796666065596 1.4379750694310185e-05 4.842248643370658 0.17450276424150757 SVGGDS(ph)DTEDMR ddPTM_A459_Selumetinib_30min_R1 1 SVGGDSDTEDMR 12 0 Q9UK61-3;Q9UK61;Q9UK61-2;A0A087X0F1;Q9UK61-4 Q9UK61-3 FAM208A Protein FAM208A 1 SVGGDS(0.975)DT(0.025)EDMR 184.96 0.00010448 10416000.0 1646.5 1684.1 1753.1 1788.6 1668.8 1697.9 1920.7 1326.2 878.21 1309.8 True False 1684.8602464687067 1486.924789083151 1515.038649088998 1476.2545861802275 1517.8573346505707 1680.8206675698525 1775.820052635558 1291.0248678952826 1490.2582280793988 1477.9255885324087 1.1400169667146678 1.0060890755397762 1.0251115894092089 0.9988693596178678 1.0270187798546844 1.137283690472482 1.2015625593159671 0.8735384771145888 1.0083445605399095 1.0 10.529357918315453 -7.777879762964345 24.999996293304285 0.9557061914699821 1.0693165126802069 0.35136392530325855 0.07162061820215355 305.8871771697867 465139.31579051097 0.040994439524746705 0.019782150186534096 1.6677088638577407e-08 7.777879762964345 0.11361032121022474 SVGGDSDT(ph)EDMR ddPTM_A459_Selumetinib_30min_R1 1 SVGGDSDTEDMR 12 0 Q9UK61-3;Q9UK61;Q9UK61-2;A0A087X0F1;Q9UK61-4 Q9UK61-3 FAM208A Protein FAM208A 1 SVGGDS(0.273)DT(0.727)EDMR 127.52 0.0060368 7516600.0 2096.9 2804.7 2810.5 3004.4 2252.6 2067.4 2038.2 2153.0 1922.1 2307.9 True False 2145.7536901428657 2476.3244201303446 2428.8495369714365 2479.7379395727803 2048.8527277288313 2046.6038330490094 1884.4569330357656 2095.895446070385 3261.663315370366 2604.141445849709 0.8239773970659742 0.9509177867726541 0.9326872550806947 0.9522285909334173 0.7867670671246155 0.7859034832039318 0.7236384705750435 0.8048316459194913 1.2524908432176631 1.0 11.346592096331499 -8.250659449613524 24.998720832107423 1.1262454264956951 0.8471665844916707 0.5951867439911844 0.09272669988007382 453.50285127654587 1051681.940787781 0.06830199621961798 0.02524342011049 5.614880922303747e-09 8.250659449613524 -0.27907884200402444 SVGGDSDT(ph)EDMR ddPTM_A459_Selumetinib_30min_R2 1 SVGGDSDTEDMR 12 0 Q9UK61-3;Q9UK61;Q9UK61-2;A0A087X0F1;Q9UK61-4 Q9UK61-3 FAM208A Protein FAM208A 1 SVGGDS(0.492)DT(0.508)EDMR 198.52 0.00029254 29046000.0 50194.0 46477.0 62707.0 67546.0 65301.0 42761.0 47168.0 52411.0 39185.0 46024.0 True False 47404.418422502196 50041.6364528907 58672.49989021934 58346.11827665072 57097.30458165304 48650.9396042902 49361.40546161889 52563.507332891895 47023.09492037857 44695.167535287124 1.0606161926806987 1.1196207378209848 1.3127258074130055 1.3054234158667395 1.2774827286769728 1.0885055876763403 1.1044013969216635 1.1760445307961462 1.0520845432171952 1.0 15.447831234453371 -6.776110554973783 24.903223890658975 1.0964720955420901 1.2202986986547173 0.3670245879853319 0.08510511118224717 295.60886336525925 501770.7151942232 0.032596450929960406 0.02886657585179492 1.6745165530902706e-07 6.776110554973783 0.12382660311262716 SVGGS(ph)GGGSFGDNLVTR ddPTM_A459_Selumetinib_30min_R2 1 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.119)VGGS(0.72)GGGS(0.16)FGDNLVTR 195.96 9.1834e-08 10821000.0 18640.0 18843.0 19180.0 23022.0 24155.0 16767.0 15672.0 21159.0 15974.0 20546.0 True False 17604.063421832125 20288.19751020547 17945.979681605033 19886.363884834842 21120.432951560164 19076.502054328328 16400.77905347887 21220.569186938992 19169.2463508518 19952.783595081022 0.8822860899554923 1.0168103820465 0.8994223585940797 0.9966711556846357 1.0585206244990801 0.9560822410278271 0.8219794985157944 1.063539284421975 0.960730429391196 1.0 14.284302409138943 -4.742273241861317 24.441430819450062 0.9724213420655552 0.8822856912105526 0.13911552935819715 0.06884753889393694 2168.618563409109 2765317.5067973896 0.01716452674313232 0.5977119743670996 1.81020082354141e-05 4.742273241861317 -0.09013565085500264 SVGGSGGGS(ph)FGDNLVTR ddPTM_A459_Selumetinib_30min_R1 3 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 SVGGS(0.039)GGGS(0.961)FGDNLVTR;SVGGS(0.001)GGGS(0.999)FGDNLVTR;S(0.263)VGGS(0.134)GGGS(0.586)FGDNLVT(0.017)R 214.46 9.1913e-10 82583000.0 4627.2 5746.8 5339.6 6933.599999999999 5605.3 4952.2 5871.400000000001 5181.6 2728.68 4951.2 True False 4735.004757036136 5073.961984385161 4614.511648323318 5722.7769197915795 5098.301604696091 4902.385364237839 5428.515570908741 5044.167135791132 4630.370665097973 5586.734748772076 0.8475442221553217 0.9082160175047475 0.8259765061044922 1.0243509271760942 0.912572698357777 0.8775045862550298 0.971679489902736 0.902882875708356 0.8288151976636612 1.0 12.447789609211148 -5.6874349532687 24.999999212226612 0.9257713121829582 0.8653429521499317 0.23322432789169467 0.05785207520599095 69.4016594649212 23442.699799448867 0.015453554085785387 0.026766336101117994 2.0538326175038353e-06 5.6874349532687 -0.06042836003302643 SVGGSGGGS(ph)FGDNLVTR ddPTM_A459_Selumetinib_30min_R2 2 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 S(0.003)VGGS(0.003)GGGS(0.853)FGDNLVT(0.141)R;SVGGS(0.002)GGGS(0.998)FGDNLVTR 160.76 2.4407e-05 59983000.0 46639.0 41194.0 40954.0 42803.0 45580.0 32032.0 32116.0 37948.0 30675.0 37818.0 True False 44046.99109070969 44353.447340413106 38319.06422734375 36973.157560706546 39853.83290962998 36444.11724245509 33609.457636646715 38058.4223973704 36810.85713111175 36726.09607703565 1.1993376861596707 1.2076820593013353 1.043374284785585 1.006727137105797 1.0851638798208685 0.9923221124840199 0.9151383138068485 1.0362773739288842 1.0023079244224136 1.0 15.164517927684491 -5.32560078336715 3.345261867816499 1.0066965049029037 1.2080833495709202 0.791989396767338 0.039964310237223195 0.10712357680887742 2.3512138441127495 0.011505531678425586 0.02903281053185359 4.724971754034217e-06 5.32560078336715 0.20138684466801648 SVICDIS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 1 SVICDISPLR 10 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 SVICDIS(1)PLR 105.2 0.012654 7798900.0 2440.9 2177.1 2878.0 3014.9 2640.3 2325.1 2063.0 2425.7 1549.9 2202.5 True False 2497.7682208353867 1922.2041198936686 2487.183407722398 2488.4043116821904 2401.485331182827 2301.7116050218883 1907.3862490691708 2361.362556215946 2630.0670997828083 2485.212329166767 1.0050522410183074 0.7734566971740954 1.000793122797798 1.0012843902623376 0.9663099216910725 0.9261629592001894 0.7674942807436789 0.9501653152540309 1.0582866779292888 1.0 11.279153401298645 -8.098493896207707 5.837439493274656 1.0252493123549271 0.9185382359858721 0.20984497347851683 0.08315761432977112 0.3748387313791696 17.969693941822218 0.05910311382696745 0.0218136148559601 7.970876931814701e-09 8.098493896207707 -0.10671107636905497 SVICDIS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 2 SVICDISPLR 10 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 1 SVICDIS(1)PLR;SVICDIS(1)PLR 102.05 0.015706 7922900.0 44589.0 50191.0 47426.0 57866.0 57571.0 49571.0 48132.0 53094.0 43839.0 52663.0 True False 42110.92188390947 54040.48831049846 44374.66279352454 49984.550975582184 50338.41628872982 56398.955289265155 50370.23337174864 53248.4947498151 52608.024964003496 51142.482355093554 0.8234039480431168 1.056665336173622 0.8676673628280586 0.9773587177198088 0.9842779225931795 1.1027809502416162 0.9849000488872828 1.041179315077024 1.0286560710669919 1.0 15.642234567396661 -6.248426920358052 2.419427904805701 1.0308136461271316 0.9305419013783548 0.3515719011354922 0.064523552405764 0.3395206465967307 3.9172922488841015 0.019943847783093632 0.02560385321846047 5.643819030799064e-07 6.248426920358052 -0.10027174474877676 SVIEPLPVT(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 SVIEPLPVTPTR 12 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 SVIEPLPVT(0.987)PT(0.013)R;S(0.003)VIEPLPVT(0.988)PT(0.01)R 122.46 0.008270999999999999 14628700.0 4049.4 5140.299999999999 4153.2 4289.9 4791.9 4202.8 5326.4 5030.0 3205.5 4554.0 True False 4143.743141239222 4538.47128633936 3589.2182518946024 3540.749496396373 4358.473491078659 4160.523647837078 4924.625359690759 4896.588060257335 5439.499379543059 5138.550259716439 0.8064031549373006 0.8832201801972464 0.6984884978224708 0.6890561184453148 0.8481912739565524 0.8096687660045713 0.9583686274895977 0.9529123610299268 1.0585669312580057 1.0 12.327145673627491 -7.339144089270516 1.379399567918628 1.0174153063321107 0.7768642916344634 0.7443856889930013 0.05931295691758872 0.23535434135138902 0.8658990166329569 0.04046024473579125 0.02212209228439576 4.579899106169038e-08 7.339144089270516 -0.2405510146976474 SVIEPLPVT(ph)PTR ddPTM_A459_Selumetinib_30min_R2 3 SVIEPLPVTPTR 12 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 S(0.183)VIEPLPVT(0.687)PT(0.13)R;SVIEPLPVT(0.973)PT(0.026)R;S(0.255)VIEPLPVT(0.373)PT(0.373)R 120.6 0.0093345 11102300.0 46058.0 41007.0 52443.0 49590.0 50947.0 40360.0 44646.1 51802.0 44039.0 47761.0 True False 43498.28074478239 44152.10504171288 49068.87447562112 42835.75645247848 44546.58238804119 45919.22364839811 46722.232114568826 51952.73524371722 52848.03055247039 46382.01583201913 0.9378264390732668 0.9519229436171494 1.0579288889325753 0.923542361927863 0.9604279070011684 0.9900221632173748 1.007335090475193 1.120105159548767 1.1394077985715216 1.0 15.501277902587663 -7.611501274137712 3.73669250972306 1.0969079226685292 0.9722552002226688 0.527223081140026 0.048704330774682614 0.168812529129138 4.56509409806521 0.024646415026646083 0.013426613432637102 2.446238099241724e-08 7.611501274137712 -0.12465272244586045 SVKTS(ph)PTTQSK ddPTM_A459_Selumetinib_30min_R1 1 SVKTSPTTQSK 11 1 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 SVKT(0.02)S(0.913)PT(0.048)T(0.02)QSK 162.48 0.0029709 19147000.0 4086.6 6396.6 9985.9 9791.8 6100.2 8638.0 4923.2 5972.1 5204.7 3664.1 True False 4181.809828860625 5647.683098301338 8629.869628622335 8081.8459448504655 5548.437987077785 8551.109562676475 4551.839060308942 5813.700507885255 8831.995763752222 4134.422926356388 1.011461551792912 1.3660148463037296 2.0873214430018954 1.954770009940151 1.342010260176152 2.068271610087179 1.1009611598493183 1.406169763335942 2.136210039725119 1.0 12.013470259915154 -10.325207258285431 7.26290719202817 0.9999999987793214 1.6101497395685784 0.17008646241422865 0.40297395276587156 7.914308368598902e-09 1.6073231763000431e-09 0.39170904468851464 0.09500339869374433 4.7292551093374375e-11 10.325207258285431 0.610149740789257 SVLSEGHQR ddPTM_A459_Selumetinib_30min_R2 1 SVLSEGHQR 9 0 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 0 129.42 0.0060673 0.0 4414.4 4896.7 2735.1 4206.0 4325.7 2911.2 4177.2 4373.3 2898.1 4294.5 False True 4169.06532024333 5272.2611446278825 2559.1266437517165 3633.1355442453028 3782.266893751344 3312.1913747575954 4371.44807696477 4386.025578961208 3477.800979679704 4170.506626548988 0.9996544049836816 1.2641776207871835 0.613624883715709 0.8711496874545553 0.9069082565829887 0.7941940083903832 1.0481815444523241 1.0516769236236794 0.8339037174861214 1.0 12.026006935289642 -10.08629665876024 16.164734734543476 0.9999971530948837 0.9323625313823095 0.014991591951768246 0.16644900630193854 0.0 0.0 0.16380173200735196 0.039727755454437026 8.197913682690765e-11 10.08629665876024 -0.06763462171257417 SVNEILGLAES(ph)SPNEPK ddPTM_A459_Selumetinib_30min_R2 3 SVNEILGLAESSPNEPK 17 0 Q9H8G2;Q9H8G2-2 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 SVNEILGLAES(0.797)S(0.203)PNEPK;SVNEILGLAES(0.675)S(0.325)PNEPK;SVNEILGLAES(0.677)S(0.323)PNEPK 176.49 3.8772e-09 1198200.0 33762.0 32735.9 35345.5 31104.1 33381.3 24571.5 30640.5 29600.0 18902.5 30143.1 True False 31885.643199994403 35246.63826749112 33071.40901127065 26867.667922434688 29187.64266139165 27956.001087131175 32065.343962998915 29686.131099456208 22683.528179978457 29272.790381820654 1.089258754771681 1.2040751089236925 1.1297661951560674 0.917837608645617 0.9970912332128786 0.955016611757407 1.095397587478115 1.0141203046325318 0.7749014659724978 1.0 14.83727265444331 -5.695018581655469 6.754291661044698 0.9720393593548715 1.149946390741646 0.49001162519392627 0.0820651461150747 0.1835443708393899 14.815541940129604 0.022453877824025272 0.038946593410753565 2.018280008022852e-06 5.695018581655469 0.17790703138677455 SVNEILGLAESS(ph)PNEPK ddPTM_A459_Selumetinib_30min_R1 2 SVNEILGLAESSPNEPK 17 0 Q9H8G2;Q9H8G2-2 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 SVNEILGLAES(0.027)S(0.973)PNEPK;SVNEILGLAES(0.023)S(0.977)PNEPK 273.77 6.0049e-52 121230000.0 7126.0 8509.6 9975.9 10437.8 7396.799999999999 8317.1 7909.7 7476.6 4978.6 6847.799999999999 True False 7292.021935217734 7513.292075994287 8621.227573696271 8615.034171772319 6727.760746011104 8233.43752532259 7313.064960863996 7278.296280580509 8448.320577442855 7726.781833220514 0.943733379900339 0.9723701585169198 1.1157591555944 1.114957605601449 0.8707067044504582 1.065571372796338 0.9464567679939163 0.9419570058634519 1.0933815344856974 1.0 12.915651948491645 -6.230153610775496 24.991467862707765 0.9854101827994267 1.0377564126028644 0.09194062478311782 0.07747198648332576 1791.051280759521 1430714.5180384829 0.023283940170305523 0.03005721651757276 5.886354170759225e-07 6.230153610775496 0.05234622980343773 SVNEILGLAESS(ph)PNEPK ddPTM_A459_Selumetinib_30min_R2 2 SVNEILGLAESSPNEPK 17 0 Q9H8G2;Q9H8G2-2 Q9H8G2 CAAP1 Caspase activity and apoptosis inhibitor 1 1 SVNEILGLAES(0.009)S(0.991)PNEPK;SVNEILGLAES(0.389)S(0.611)PNEPK 191.4 4.0735e-15 0.0 26481.7 25030.2 23893.3 24282.4 24051.3 18517.9 20306.4 22607.0 17128.1 21647.0 True False 25009.9531286444 26949.93585522184 22356.031091058052 20975.095230523562 21029.760672649907 21068.572636240628 21250.687836368248 22672.78262720968 20554.198599100084 21021.994864339496 1.1897040832727939 1.2819875577525786 1.0634590691952617 0.9977690207747366 1.0003694134814762 1.002215668503475 1.0108787474026404 1.078526694232548 0.9777472942859027 1.0 14.359611958665608 -5.386389187489375 4.261436888542306 1.0133383250938426 1.2346240437061067 0.8776432751555748 0.033184871483303284 0.06544250568978494 1.933772499403552 0.008591825056157852 0.018996857982958824 4.107814395389353e-06 5.386389187489375 0.2212857186122641 SVNFS(ph)LTPNEIK ddPTM_A459_Selumetinib_30min_R2 1 SVNFSLTPNEIK 12 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.308)VNFS(0.498)LT(0.194)PNEIK 156.2 0.00043309 66956000.0 404310.0 449800.0 433620.0 473640.0 504910.0 364320.0 504660.0 491550.0 380700.0 502280.0 True False 381840.0687811664 484298.2136650428 405721.36128975806 409129.4149254267 441478.6918473288 414501.7730323195 528127.6899648196 492980.32911951724 456850.6376467553 487777.87131983467 0.7828154806366664 0.9928663068593567 0.8317748408552295 0.8387617376294663 0.9050814270290101 0.849775681522321 1.0827217080098488 1.0106656289790386 0.9365956606653842 1.0 18.895864784310795 -7.247246257400198 24.814065389736438 1.0083845534026064 0.8714413911314355 0.5574004292954278 0.06131572484452045 544.9241563413436 952700.963702561 0.02285026705038671 0.01761056160923984 5.659183061681536e-08 7.247246257400198 -0.13694316227117087 SVNFSLT(ph)PNEIK ddPTM_A459_Selumetinib_30min_R1 2 SVNFSLTPNEIK 12 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 SVNFS(0.02)LT(0.98)PNEIK;S(0.051)VNFS(0.01)LT(0.939)PNEIK 194.55 0.00038068 394690000.0 10915.5 11443.0 12025.8 12103.5 11180.3 9271.1 10431.0 10481.5 6333.9 9897.400000000001 True False 11169.80991213432 10103.248240293631 10392.76241299097 9989.850935833827 10169.043839042282 9177.84115148529 9644.18127195372 10203.496571289705 10748.165690247319 11167.827698840025 1.000177493183791 0.9046744373879471 0.9305983843277275 0.894520510633545 0.9105659679991764 0.8218107763641957 0.8635682365475102 0.9136509665482677 0.9624222346628525 1.0 13.447060967976611 -8.391148612618352 2.616797802195624 0.9981012713548639 0.9009389637641289 0.3482087256373776 0.04315968438055315 0.3019813533826688 4.030475304162433 0.043367322963944015 0.01188929937502346 4.0630427081569795e-09 8.391148612618352 -0.09716230759073508 SVNFSLT(ph)PNEIK ddPTM_A459_Selumetinib_30min_R2 1 SVNFSLTPNEIK 12 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 S(0.001)VNFS(0.092)LT(0.907)PNEIK 118.52 0.010526 15727000.0 45264.0 46061.0 53070.0 51818.0 55463.0 48715.0 44301.0 49509.0 42046.0 64958.0 True False 42748.40808614853 49593.73059054156 49655.53397824711 44760.29900896411 48495.24209448894 55425.04905925952 46361.084280766125 49653.06299334385 50456.37486339768 63082.493758847166 0.6776588168750568 0.7861726389595396 0.787152362239691 0.709551831924631 0.7687591153240926 0.8786122069165393 0.7349278939097759 0.7871131915481722 0.7998474989952549 1.0 15.944952073007117 -14.52287874527464 0.19934712108415695 2.032504105543519 0.735157558923238 0.686856988442081 0.048322292069634475 83.22645572443355 0.8205885070374676 34.193959641763456 0.11784345474956194 3.000000000039353e-15 14.52287874527464 -1.2973465466202811 SVPGTTSS(ph)PLVGDISPK ddPTM_A459_Selumetinib_30min_R2 2 SVPGTTSSPLVGDISPK 17 0 Q9UQR0;H0Y6S1;B4DRC2;Q9UQR0-2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 SVPGTTS(0.042)S(0.958)PLVGDISPK;SVPGTTS(0.019)S(0.981)PLVGDISPK 358.02 1.152899999999999e-197 44130000.0 50921.0 54090.0 54108.0 61171.0 59271.0 39171.0 48452.0 46992.0 41327.0 54317.0 True False 48091.01467291377 58238.52907323749 50626.750188336024 52839.40427413916 51824.847090537034 44566.44969106548 50705.11400581659 47128.738940055606 49593.55477285917 52748.72707748546 0.9117000037227491 1.1040745871969149 0.9597719792170084 1.001719040471261 0.9824852647990673 0.8448819935616533 0.9612575850661401 0.8934573695176691 0.9401848636083391 1.0 15.68684865893975 -6.545629851721094 24.98686580706454 0.9223015104405515 0.9987404987829149 0.22465342205739924 0.05907533038425721 291.6516213692546 320310.05839170964 0.018163335251866246 0.018164330791763515 2.8468864691211393e-07 6.545629851721094 0.0764389883423634 SVPGTTSSPLVGDIS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SVPGTTSSPLVGDISPK 17 0 Q9UQR0;H0Y6S1;B4DRC2;Q9UQR0-2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 SVPGTTSS(0.001)PLVGDIS(0.999)PK 264.01 1.3231e-40 96136000.0 1935.2 2331.5 2482.2 2635.4 1597.2 2119.5 1632.7 1842.7 1302.8 2240.0 True False 1980.2863947562957 2058.526896115055 2145.1308737486215 2175.1768625849095 1452.7335420085628 2098.179754352026 1509.5441245056882 1793.8256100668375 2210.756447252752 2527.525819447701 0.7834880971419772 0.8144434688959463 0.848707798449854 0.8605953086011265 0.5747650650413554 0.8301318776678243 0.5972418215832684 0.7097160378202637 0.8746721518104343 1.0 11.303510114435836 -8.52062119149251 3.8433427087309218 0.9993678864211233 0.7535069449542651 0.41043768094278144 0.09462500772401726 0.1933127421873373 8.083984143924331 0.09400808421795989 0.02468974081831024 3.0156352314943363e-09 8.52062119149251 -0.24586094146685822 SVPGTTSSPLVGDIS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 SVPGTTSSPLVGDISPK 17 0 Q9UQR0;H0Y6S1;B4DRC2;Q9UQR0-2 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 SVPGTTSSPLVGDIS(1)PK 249.41 1.7537999999999997e-30 11518000.0 86463.0 80583.0 84033.0 70390.0 74949.0 64027.0 75544.0 68412.0 44352.0 74605.0 True False 81657.7325988128 86763.4569848158 78626.40826821238 60802.76057047714 65533.23656743871 72846.1380707629 79056.94568759619 68611.0675937838 53223.63929842111 72450.95980293087 1.127075925852807 1.1975473785415047 1.0852362547311858 0.8392264331054105 0.9045185425519744 1.0054544241913004 1.0911787214777255 0.9470001195347624 0.7346160691754984 1.0 16.14471718173685 -5.574865242304386 5.849055966177947 0.9385954620362407 1.158001033587264 0.5131855317129443 0.09322341581938536 0.1571487728917922 11.750340197147445 0.02689079047670549 0.047727765992121904 2.661550787102149e-06 5.574865242304386 0.21940557155102325 SVPHEEYR ddPTM_A459_Selumetinib_30min_R2 2 SVPHEEYR 8 0 A0A0A0MQW0;A0A0A0MR39;Q9P2K5-2;Q9P2K5;H0YN19;A0A087WUT0 A0A0A0MQW0 MYEF2 Myelin expression factor 2 0 ; 160.11 0.00063073 2196850.0 1636.52 1445.64 1552.9299999999998 746.26 3108.63 2094.1 1927.1 740.36 493.17 1889.3000000000002 False True 1545.568769908622 1556.5159395347575 1453.0161745023418 644.6181006296954 2718.0961078951964 2382.5432666528864 2016.7139684762062 742.514325026804 591.8177803211202 1834.7510000090817 0.8423861166452405 0.8483526862920653 0.7919418899322849 0.3513381928264406 1.4814523103580497 1.2985649097022391 1.099175838283355 0.4046948741399398 0.3225602712946829 1.0 10.841368568206226 -7.763278279401086 24.99997397355724 0.5227206213549064 0.9581263893298517 0.21238716132350866 0.3335728893156478 73.17415296828442 994749.5580880477 0.18194794125532937 0.0944528275583871 1.7247323948678707e-08 7.763278279401086 0.43540576797494535 SVPHLQK ddPTM_A459_Selumetinib_30min_R2 1 SVPHLQK 7 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 87.323 0.047408 56016000.0 616790.0 542500.0 576750.0 692100.0 608780.0 364550.0 507440.0 524590.0 410770.0 501080.0 False True 582511.2810059994 584108.005587565 539642.53291792 597834.7860609078 532299.6138377478 414763.45344458654 531036.965473284 526116.4700494504 492935.4778727542 486612.51843780756 1.197074179012204 1.2003554850227678 1.1089779084400806 1.2285643369392996 1.093888039597936 0.8523485067258831 1.0912932679539238 1.0811815358521069 1.012993828139164 1.0 18.892413909501144 -6.52236807067722 24.99899592438051 1.0128979273102607 1.1772938568717581 0.6044704145613636 0.06705952100895922 13.78248007596944 674738.1488881649 0.02227227929248347 0.0225141232549684 3.003529690010175e-07 6.52236807067722 0.1643959295614974 SVPS(ph)IS(ph)SEADDSIPLSS(ph)GY(ph)EK ddPTM_A459_Selumetinib_30min_R2 1 SVPSISSEADDSIPLSSGYEK 21 0 C9J879;Q9H3R0-3;Q9H3R0-4;Q9H3R0-2;Q9H3R0 C9J879 KDM4C Lysine-specific demethylase 4C 4 S(0.083)VPS(0.893)IS(0.512)S(0.512)EADDS(0.023)IPLS(0.572)S(0.727)GY(0.679)EK 49.924 0.048176 6243200.0 666.58 2144.6 3735.8 4212.6 7737.5 3595.6 790.64 3528.0 5874.7 3438.2 True False 629.5341521311617 2309.083924024128 3495.4426952314957 3638.83661285967 6765.446075872351 4090.8612623929707 827.4063266234382 3538.265895908161 7049.804152832666 3338.9302324835803 0.18854366767133626 0.6915639930297595 1.0468750323757132 1.089821098224329 2.0262316385209527 1.2252011804841112 0.24780581474084667 1.0597004577949236 2.111396064597865 1.0 11.705170233019231 -4.967036195696716 1.5032476486556803 1.237533938652422 4.054082596842467e-08 0.3163129946823483 0.49783675854483156 1.061645013640035 2.9225792807336424 0.1533835915189194 1.7749687521481472 1.07885680259561e-05 4.967036195696716 -1.237533898111596 SVPTAYRVS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 SVPTAYRVSR 10 1 Q12872;Q12872-2 Q12872 SFSWAP Splicing factor, suppressor of white-apricot homolog 1 SVPTAYRVS(1)R;SVPTAYRVS(1)R 96.23 0.012055 15749300.0 42582.0 42054.0 46173.0 48625.0 53172.0 40813.0 42222.0 49279.0 36044.0 40029.0 True False 40215.46290925188 45279.40657507726 43202.27944936131 42002.191117196366 46492.057996288815 46434.62028647357 44185.40666130582 49422.393731422395 43253.80715350583 38873.25876216776 1.0345276982126947 1.1647957494920413 1.1113624333292746 1.0804906111466464 1.195990752427883 1.1945131888882101 1.1366530120780085 1.2713725400228413 1.1126879641899565 1.0 15.246490434048097 -3.341601405846069 0.8542386781904096 1.1561473959062047 7.842682081171164e-29 0.11837100850705495 0.07204304058096501 43.10167559335197 3.395711064937966 0.023945047383198793 80.3490149559201 0.00045540583849564464 3.341601405846069 -1.1561473959062047 SVPTS(ph)TVFYPSDGVATEK ddPTM_A459_Selumetinib_30min_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 SVPT(0.003)S(0.919)T(0.078)VFYPSDGVATEK 243.83 2.0093e-25 7765900.0 1044.5 3800.3 2079.1 3080.1 2072.4 2162.0 2402.9 2294.6 482.91 1411.4 True False 1068.8348177567952 3355.3591092884603 1796.7696396788185 2542.218355637769 1884.951785911938 2140.2522429389373 2221.647318414112 2233.7397540887623 819.4629996490839 1592.566938200215 0.6711396501579409 2.1068873331505955 1.1282223664076414 1.596302356063457 1.183593443200668 1.343900963659129 1.3950103227213988 1.4026033697604867 0.5145548234067775 1.0 10.637138297256655 -8.24861665664088 24.582021637917634 0.7572774316287059 1.3745632358068944 0.30341921678294925 0.36019410679378 578.9863694202568 1109962.3169331797 0.22435389377678866 0.08352271738310638 5.641353875456925e-09 8.24861665664088 0.6172858041781886 SVPTS(ph)TVFYPSDGVATEK ddPTM_A459_Selumetinib_30min_R2 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 SVPT(0.129)S(0.601)T(0.27)VFYPSDGVATEK 116.04 0.0017195 0.0 11504.0 8691.9 8167.1 11247.0 9403.6 10076.0 8204.1 9397.3 9134.4 11789.0 True False 10864.653734160762 9358.540781136498 7641.637677666138 9715.139197842827 8222.235698749373 11463.877539178879 8585.606906115747 9424.644587193234 10961.53523646054 11448.620938499475 0.9489923539720889 0.8174382601545969 0.667472328651288 0.8485859781742544 0.7181856874219323 1.0013326147106592 0.7499249867941762 0.8232122137523128 0.9574546397635579 1.0 13.482886206254973 -8.328155394945401 3.5473684633411 0.9955775693217698 0.8170030270073715 0.30950898192216714 0.09442530325519245 0.27936332584207596 6.526675524344102 0.08706000939617956 0.02370555469491484 4.697260058305921e-09 8.328155394945401 -0.1785745423143983 SVPTST(ph)VFYPSDGVATEK ddPTM_A459_Selumetinib_30min_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 SVPT(0.3)S(0.173)T(0.526)VFYPSDGVATEK 272.95 7.2161e-54 8902900.0 1167.2 4837.6 2551.6 3979.8 2179.5 2798.3 2693.1 3038.6 747.09 1564.3 True False 1194.3934890241574 4271.211543060773 2205.1067349355358 3284.8026400984404 1982.3646098219783 2770.151642653113 2489.9572987727506 2958.0064572361707 1267.7571647052948 1765.0931425723377 0.6766744826188165 2.419822183908195 1.249286330421039 1.860979775441976 1.1230934855556702 1.5694081948650398 1.4106662355189035 1.6758359011725323 0.7182381111388512 1.0 10.78552860004618 -8.262242663774536 24.99975578575961 0.8591189980481496 1.519685205457964 0.25031545679994116 0.44116116471953937 90.49689576267367 2816169.8055355125 0.32146511573941594 0.10165649633919582 5.467104009171259e-09 8.262242663774536 0.6605662074098143 SVPTSTVFYPSDGVATEK ddPTM_A459_Selumetinib_30min_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 214.42 4.3747e-11 12696000.0 815.38 1118.7 1006.4 1178.5 914.63 910.17 730.08 740.55 612.78 856.83 False True 834.3767675467079 987.7220839304795 869.736407759493 972.697098184836 831.901877991042 901.0145161682395 675.0094778092199 720.9082083545862 1039.8429043195738 966.8124767309694 0.8630182042829452 1.0216273659088582 0.899591625772441 1.0060866213412596 0.8604583598299298 0.9319434097652433 0.6981803545725773 0.7456546390383315 1.0755373242963706 1.0 9.917092281001668 -6.288679726658599 22.831863131668552 0.8655550012849917 0.9494421785607792 0.05180508256041949 0.11285622748214713 578.88094402271 485194.1314605784 0.034920948163712634 0.03961307352377056 5.144228762907729e-07 6.288679726658599 0.08388717727578743 SVPTSTVFYPSDGVATEK ddPTM_A459_Selumetinib_30min_R2 2 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 ; 256.57 2.8798e-41 18380400.0 55122.0 46404.0 64437.0 63951.0 67172.0 48454.0 50311.0 63113.0 52044.0 55999.0 False True 52058.53991084927 49963.03758762273 60291.19357370096 55240.7634783717 58733.25283470089 55128.098678381604 52650.5611893552 63296.64838108036 62454.25423085829 54382.16336712461 0.9572723240046749 0.918739426571372 1.1086575053420642 1.0157882669258822 1.080009495727539 1.0137165435332411 0.968158637491494 1.1639229567565306 1.1484326912344474 1.0 15.730845923647355 -5.253578485633614 24.750012657664666 1.0620590786120896 0.9380058608545601 0.3928757305998283 0.0618217513438848 546.8716783462781 1721812.2401377745 0.016493740211972484 0.041998392840382405 5.5772680072931255e-06 5.253578485633614 -0.12405321775752953 SVPVNNLPERSPT(ph)DSPR ddPTM_A459_Selumetinib_30min_R1 2 SVPVNNLPERSPTDSPR 17 1 P49454 P49454 CENPF Centromere protein F 1 SVPVNNLPERS(0.01)PT(0.988)DS(0.003)PR;SVPVNNLPERS(0.218)PT(0.715)DS(0.067)PR 274.16 5.3917e-51 19770600.0 3260.0 4046.5 4345.7 4372.7 4292.200000000001 3360.0 3990.6000000000004 3901.0 2479.91 3242.4 True False 3335.951657144237 3572.7338988331844 3755.5778092214123 3609.09003074487 3903.971267849459 3326.2014506359087 3689.5858291495083 3797.5328077661766 4208.2261445398935 3658.5936236505436 0.9118125707045937 0.9765320410929683 1.0265085974413573 0.9864692288901223 1.0670688437799434 0.909147555807804 1.0084710707684557 1.0379761182596168 1.1502305468790839 1.0 11.837073462650347 -7.8467941048442205 3.1889200078944646 1.0790372608602135 0.9847850434397993 0.3047314508670228 0.05624370139024692 0.2892201459113432 5.771287715235105 0.034440655449591906 0.01495403965257001 1.4230032604336893e-08 7.8467941048442205 -0.09425221742041412 SVPVNNLPERSPT(ph)DSPR ddPTM_A459_Selumetinib_30min_R2 1 SVPVNNLPERSPTDSPR 17 1 P49454 P49454 CENPF Centromere protein F 1 SVPVNNLPERS(0.036)PT(0.929)DS(0.036)PR 196.01 9.4732e-07 4044900.0 20030.0 16558.0 21701.0 21107.0 22338.0 17662.0 18723.0 15499.0 17193.0 23655.0 True False 18916.812786443 17827.945357638488 20304.781286262292 18232.190188394114 19531.70073574625 20094.780180327245 19593.656598920672 15544.099524002428 20632.080412557585 22972.018686928925 0.8234719396779292 0.7760722120508541 0.883891901838636 0.7936694827245734 0.8502387622930059 0.874750297489579 0.8529357766050164 0.676653616551645 0.8981396321211089 1.0 14.487590019968161 -8.527272761342994 24.68741097471912 1.0000000073645563 0.8187938629213265 0.5082089507199401 0.056749834520220414 331.5874672576383 1862999.2165352253 0.054078499748994695 0.013963008596424452 2.969800244426538e-09 8.527272761342994 -0.1812061444432298 SVPVNNLPERSPTDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 SVPVNNLPERSPTDSPR 17 1 P49454 P49454 CENPF Centromere protein F 1 SVPVNNLPERS(0.171)PT(0.045)DS(0.784)PR 209.23 1.983e-08 4736400.0 10874.0 10167.0 12419.0 11602.0 13727.0 11032.0 7678.8 9584.7 9361.1 11245.0 True False 10269.666612070947 10946.77620794242 11619.975060784822 10021.787585433667 12002.491539062981 12551.55786147493 8035.8794152535365 9612.589890167494 11233.58157098778 10920.327631981228 0.9404174451685169 1.0024219580998406 1.0640683551246768 0.9177185816370472 1.0990962857114774 1.1493755759411912 0.7358643152536644 0.8802473894662374 1.0286853975048476 1.0 13.414728520234313 -7.24898208671645 24.98474150464753 0.9012198789893857 1.027390890472648 0.25596027888294737 0.09765772355550871 1036.300777708869 2078440.6036539148 0.03816753186166242 0.02934497500589482 5.636609045887145e-08 7.24898208671645 0.12617101148326237 SVQEGENPDDGVRGS(ph)PPEDYR ddPTM_A459_Selumetinib_30min_R1 1 SVQEGENPDDGVRGSPPEDYR 21 1 H7C5M1;Q5TCT4;A2A2V2;P42696-2;P42696 H7C5M1 RBM34 RNA-binding protein 34 1 SVQEGENPDDGVRGS(0.977)PPEDY(0.023)R 74.63 0.0017555999999999995 28323000.0 825.96 794.43 1081.9 1034.4 782.63 692.02 688.5 430.01 258.19 368.92 True False 845.2032609616109 701.417766279513 934.9839224513079 853.7614580928247 711.8412546845494 685.0589071038868 636.5658906854695 418.604737930667 438.1295725485017 416.2744755851095 2.03039895677871 1.6849886491205355 2.2460755518029485 2.050957981252129 1.7100285903525443 1.6456903972816919 1.5291975079440592 1.005597898699607 1.0525016503418159 1.0 8.701391290228077 -7.365203882694224 0.9952638374472739 0.9566031739336798 1.984106994466467 0.8667913315231022 0.15678411122360408 0.19205107087588044 0.3615477138730603 0.12410462487485854 0.06519876070630239 4.313165446114113e-08 7.365203882694224 1.0275038205327873 SVQEGENPDDGVRGS(ph)PPEDYR ddPTM_A459_Selumetinib_30min_R2 2 SVQEGENPDDGVRGSPPEDYR 21 1 H7C5M1;Q5TCT4;A2A2V2;P42696-2;P42696 H7C5M1 RBM34 RNA-binding protein 34 1 SVQEGENPDDGVRGS(0.942)PPEDY(0.058)R;S(0.012)VQEGENPDDGVRGS(0.987)PPEDY(0.001)R 68.168 0.004370000000000001 67248000.0 48484.0 54153.0 54862.0 55954.0 56889.0 36301.0 39696.0 35389.0 19913.4 47377.0 True False 45789.453376829864 58306.36097066056 51332.23864922918 48332.96867396614 49742.09522588723 41301.133242331525 41541.942656131774 35491.97613103567 23896.636426884434 46009.10290977098 0.9952259548861042 1.2672788053487127 1.1156974468704044 1.0505088258024182 1.081135950932081 0.8976730827229491 0.9029070342362507 0.7714120442782686 0.5193893146264646 1.0 15.48963170644829 -7.030750286925243 1.1193419616506697 0.7442927837262374 1.1277977876178067 0.5574831639508715 0.12988242683935003 0.33910158126967616 0.867865692456956 0.07688387092358791 0.05364448284449435 9.316434030370609e-08 7.030750286925243 0.3835050038915693 SVS(ph)CDNVSK ddPTM_A459_Selumetinib_30min_R2 1 SVSCDNVSK 9 0 Q96CB8;A0A087WXN4 Q96CB8 INTS12 Integrator complex subunit 12 1 S(0.05)VS(0.913)CDNVS(0.037)K 109.39 0.011459 46425000.0 151540.0 121300.0 130400.0 146290.0 164900.0 90120.0 112250.0 133410.0 94746.0 130970.0 True False 143118.01346268452 130603.31995902583 122010.20596878491 126365.04963567441 144183.78777529587 102533.2119720922 117469.84741915527 133798.2010127857 113697.8474244277 127188.5557990735 1.1252428535219445 1.0268480457105498 0.9592860395516315 0.9935253124133273 1.1336223362978557 0.806151240006761 0.9235881851251508 1.051967295109112 0.8939314288939818 1.0 16.956609339754884 -6.748283943174049 24.999929007286184 0.9376543399147315 1.0386240332304277 0.33739402191642776 0.07832731920077429 316.95225058969737 602319.2258440432 0.026540749302839325 0.026385624610364315 1.7853199450864922e-07 6.748283943174049 0.10096969331569627 SVS(ph)EAALAQPQGPLGTDSLK ddPTM_A459_Selumetinib_30min_R2 1 SVSEAALAQPQGPLGTDSLK 20 0 Q05469;M0R201;M0QY29;Q05469-2 Q05469 LIPE Hormone-sensitive lipase 1 S(0.015)VS(0.985)EAALAQPQGPLGTDSLK 166.28 1.3054e-08 0.0 9677.2 11408.0 11425.0 13254.0 14517.0 9583.1 8373.8 9763.1 8909.6 11503.0 True False 9139.379964900956 12282.956917498497 10689.92793859945 11448.782335574715 12693.244676373368 10903.085038279585 8763.198292369912 9791.509004631793 10691.76895502373 11170.878501616718 0.818143350460597 1.0995515630861827 0.9569460393873533 1.0248775272166621 1.1362798972825927 0.9760275377358749 0.7844681410778613 0.8765209471407915 0.9571108443688069 1.0 13.447455026435014 -7.0135601062874695 24.471399610989362 0.8922368742663825 1.0150538832883438 0.19818660146888523 0.0957940505902052 658.1155164936027 1187674.9920199893 0.034645038809398905 0.028084588682121523 9.692591147091126e-08 7.0135601062874695 0.12281700902196124 SVS(ph)EESANSLVSVGVEAK ddPTM_A459_Selumetinib_30min_R1 1 SVSEESANSLVSVGVEAK 18 0 Q8NEZ4;Q8NEZ4-3;C9J4Z5;H0YMU7 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 1 S(0.051)VS(0.94)EES(0.009)ANSLVSVGVEAK 234.51 2.1441999999999998e-19 4380000.0 1154.7 1153.6 1437.6 1168.3 1419.6 1319.6 1386.2 1237.0 525.91 1006.6 True False 1181.6022633449224 1018.5359757059101 1242.3818161715499 964.2783367071224 1291.197430650736 1306.3260221009348 1281.6378179639778 1204.1907416577185 892.4308590533425 1135.8069151143095 1.0403196596368707 0.8967509901129656 1.0938318825489053 0.8489808645073057 1.1368106792348482 1.1501303652209793 1.1283940966629804 1.0602072637817377 0.7857240937501483 1.0 10.149501885100408 -4.398951079449468 20.532381418431736 1.0193505103474312 8.38826423259159 0.001110018314022243 0.12207363266266792 5022.077266156169 833760.2307632007 0.029871108306770183 3560.1260008425284 3.99069852547296e-05 4.398951079449468 7.368913722244159 SVS(ph)EINSDDELSGK ddPTM_A459_Selumetinib_30min_R2 2 SVSEINSDDELSGK 14 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.124)VS(0.784)EINS(0.092)DDELSGK;S(0.004)VS(0.898)EINS(0.097)DDELSGK 276.1 2.2376e-45 82659500.0 88323.0 78107.0 93524.0 95024.0 89963.0 67799.0 69992.0 75165.0 62479.0 79269.0 True False 83414.36124498268 84097.55574641081 87506.76766123217 82081.56727445686 78661.04366057565 77137.69683195592 73246.76668651687 75383.7177057644 74976.54580911914 76980.29800440371 1.0835806486513069 1.0924555753421474 1.1367423864249822 1.06626720605526 1.0218334521915697 1.0020446637858327 0.9515001706323187 0.9792598841518128 0.9739705840685373 1.0 16.232201635637708 -6.381146556904484 1.6276017188537244 0.9762712474812483 1.1033351611433717 0.891225724499376 0.01897457830236069 0.11235203158409951 0.594374015416682 0.0072756549698428106 0.0089189013637541 4.1577028108516433e-07 6.381146556904484 0.12706391366212344 SVS(ph)ENSLVAMDFSGQTGR ddPTM_A459_Selumetinib_30min_R2 1 SVSENSLVAMDFSGQTGR 18 0 A0A2R8YCL1;Q13322-3;Q13322-2;Q13322-4;Q13322 A0A2R8YCL1 GRB10 Growth factor receptor-bound protein 10 1 S(0.019)VS(0.758)ENS(0.223)LVAMDFSGQTGR 85.054 0.029512 3148900.0 22004.0 17693.0 23357.0 20013.0 22366.0 22269.0 19053.0 17299.0 16896.0 18040.0 True False 20781.1057689911 19049.996208038287 21854.236049178762 17287.194875649373 19556.183125423075 25336.35261214512 19939.002252803275 17349.337225996387 20275.67211368424 17519.138326450986 1.1861945137801146 1.0873820306148254 1.247449254749162 0.9867605674160688 1.1162753989958794 1.4462099756294202 1.1381268805155045 0.9903076796763327 1.1573441419245687 1.0 14.096644197711877 -7.537735606295385 21.923533861487563 1.0571386468834445 1.1763757501102918 0.18800712731671598 0.11967312007140231 107.4135918275336 158495.94067363662 0.058009222784608544 0.03352475323739661 2.8991079956367987e-08 7.537735606295385 0.11923710322684733 SVS(ph)GSPEPAAK ddPTM_A459_Selumetinib_30min_R1 1 SVSGSPEPAAK 11 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 S(0.355)VS(0.627)GS(0.018)PEPAAK 176.18 7.182899999999999e-05 7713200.0 4193.8 5034.4 5081.7 5371.2 4667.4 4474.7 4820.7 4228.8 2792.6 3395.3 True False 4291.507380285731 4444.970107570938 4391.633051780026 4433.220749911234 4245.234494096397 4429.688580702529 4457.070717832166 4116.63848692171 4738.838236565887 3831.119828022668 1.1201704913784125 1.1602273766166935 1.1463053229652314 1.1571605558992197 1.1080923293092253 1.1562385880759039 1.1633858813892977 1.0745261625101412 1.2369329202140134 1.0 11.903550435088583 -10.764305124278778 4.8426786375313275 0.9999692194894767 1.145148679466006 0.5446032480602807 0.04029583282757967 1.2210134940542386e-05 1.9126173705751267e-06 0.03557406584890568 0.008626150075717567 1.7206592587006432e-11 10.764305124278778 0.14517945997652926 SVS(ph)GSPESDELQELR ddPTM_A459_Selumetinib_30min_R1 1 SVSGSPESDELQELR 15 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 S(0.001)VS(0.818)GS(0.091)PES(0.091)DELQELR 214.89 2.2473000000000005e-07 6789100.0 1577.2 2353.5 2160.8 2746.0 2081.2 1799.1 1706.1 1741.0 1005.4 1611.5 True False 1613.945691303033 2077.951125887534 1867.3752284247946 2266.4626488040376 1892.9558274657045 1781.0026874521018 1577.4075034110087 1694.823024434993 1706.0903684893442 1818.351722339271 0.8875871876023667 1.1427663308253113 1.0269604089699742 1.24643798059502 1.0410284238246585 0.9794599502239751 0.8674930620032671 0.9320655644413167 0.9382620246288188 1.0 10.828415570550414 -6.801792498282406 3.194812314894071 0.9291481895935525 1.0829428003830175 0.33051453879011405 0.09044292506582957 0.2610139586111341 5.464407998605311 0.03265650605127395 0.02968062620468345 1.5783652172586191e-07 6.801792498282406 0.153794610789465 SVS(ph)GSPESDELQELR ddPTM_A459_Selumetinib_30min_R2 1 SVSGSPESDELQELR 15 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 S(0.011)VS(0.906)GS(0.079)PES(0.003)DELQELR 141.06 0.00038699 3632500.0 12478.0 9792.0 9969.9 14259.0 17018.0 9883.3 9682.1 9760.6 8072.7 12049.0 True False 11784.522713391694 10543.014913757466 9328.44748840636 12316.899601853012 14880.046697149679 11244.634863335314 10132.336834717185 9789.001730045678 9687.465570083968 11701.114062938352 1.0071282657364675 0.9010265908911184 0.7972272929081956 1.0526262316222585 1.271677775048801 0.9609883984424293 0.8659292423112044 0.8365871554958153 0.8279096774868357 1.0 13.514358274876138 -7.176209145278345 4.926857023807484 0.8692017835987119 1.0016476967589778 0.17953856499706145 0.12166759337370776 0.40868893219095803 17.079269227811306 0.052738424335707905 0.0402752326023078 6.664857291855727e-08 7.176209145278345 0.13244591316026588 SVS(ph)KESVASMGADSGDDFASDGSSSR ddPTM_A459_Selumetinib_30min_R1 1 SVSKESVASMGADSGDDFASDGSSSR 26 1 Q5T165;Q92805 Q5T165 GOLGA1 Golgin subfamily A member 1 1 S(0.221)VS(0.603)KES(0.132)VAS(0.044)MGADSGDDFASDGSSSR 53.705 0.0073782 13760000.0 720.77 1189.7 883.72 1106.7 954.72 1015.5 1030.0 977.8 509.22 829.7 True False 737.5625386257209 1050.4093709234746 763.7156779264894 913.4356203319113 868.3657445695059 1005.2849920002271 952.3062707422423 951.8655676579762 864.1091480427132 936.2000769623914 0.7878257615816773 1.1219923996712844 0.8157611783203998 0.9756841970101712 0.9275429108989375 1.0737928961317644 1.017203794547966 1.0167330585427992 0.9229962369223622 1.0 9.870673073424523 -6.722621343544225 24.989779074150217 1.0078822351255528 0.933325324775659 0.15845725659520182 0.09175600415368555 317.32654619295784 204283.62633813074 0.0284439789245898 0.028443422354552477 1.8939942511616937e-07 6.722621343544225 -0.07455691034989376 SVS(ph)KESVASMGADSGDDFASDGSSSR ddPTM_A459_Selumetinib_30min_R2 2 SVSKESVASMGADSGDDFASDGSSSR 26 1 Q5T165;Q92805 Q5T165 GOLGA1 Golgin subfamily A member 1 1 S(0.129)VS(0.435)KES(0.435)VAS(0.001)MGADSGDDFASDGSSSR;S(0.064)VS(0.543)KES(0.17)VAS(0.223)MGADSGDDFASDGSSSR 81.525 7.1408e-05 31422000.0 71573.0 63814.0 53569.0 57985.0 62823.0 40071.0 43797.0 49173.0 34319.0 56994.0 True False 67595.25918942012 68708.32860564948 50122.42886151724 50087.342970295715 54930.6130952541 45590.416521678926 45833.647282109116 49316.08528897165 41183.75895297875 55348.435131804166 1.2212677563232264 1.2413779801006242 0.9055798730742439 0.904945963711893 0.992451059626978 0.8236983830367028 0.8280929202959942 0.8910113749653922 0.7440817225438385 1.0 15.756254907766747 -5.279041028519932 5.464300653393998 0.8811970263329681 1.2342164127465869 0.7836371912569315 0.07254106832117566 0.06752156110790263 6.9875963858248245 0.01905877613147528 0.044142057317052334 5.259675750144629e-06 5.279041028519932 0.35301938641361874 SVS(ph)LLNACK ddPTM_A459_Selumetinib_30min_R2 1 SVSLLNACK 9 0 G3V538;F8W717;A0A3B3IU69;O00423-3 G3V538 EML1 Echinoderm microtubule-associated protein-like 1 1 S(0.08)VS(0.92)LLNACK 109.39 0.011459 4330400.0 52170.0 42750.0 46706.0 54765.0 50112.0 41646.0 36978.0 41407.0 34929.0 44650.0 True False 49270.600253056975 46028.78753708453 43700.986809647795 47305.91252510556 43816.482553035916 47382.358475252404 38697.55027051694 41527.48751470211 41915.77599780283 43360.83848536788 1.136292608125725 1.0615290004739404 1.007844597479237 1.0909824204868397 1.0105081931896172 1.092745438749797 0.8924539197639233 0.957718738043213 0.9666735575684801 1.0 15.404105034465081 -7.252603345200933 24.999047733257562 0.9506881142823947 1.0622986832304881 0.6136436520663827 0.043589919099976324 427.703883177043 1210068.6186851608 0.016468749184768167 0.012560685917972053 5.58980496118619e-08 7.252603345200933 0.1116105689480934 SVS(ph)PCSNVESR ddPTM_A459_Selumetinib_30min_R1 1 SVSPCSNVESR 11 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 S(0.38)VS(0.62)PCSNVESR 149.82 0.00062438 24923000.0 3171.4 4056.5 3413.3 3345.9 3589.2 3470.5 3205.2 3341.5 2549.5 2949.2 True False 3245.287449529825 3581.563094184312 2949.792607914823 2761.601375321716 3264.5574937247284 3435.5899209618788 2963.4291834786745 3252.872565278305 4326.315291887389 3327.7585476406944 0.9752172229654885 1.076268918826325 0.8864202632748578 0.8298683139976093 0.9810079207937805 1.032403604942322 0.890518089294573 0.977496569750987 1.3000688691655977 1.0 11.700335044235318 -8.100381897224741 8.611802073858973 1.1489120294389898 0.9532103560488904 0.399105533796154 0.09555841611386941 0.32185757459023123 25.139645736268083 0.0636061823348236 0.023938964249124804 7.936300485308436e-09 8.100381897224741 -0.19570167339009947 SVS(ph)PLLSTHVLGK ddPTM_A459_Selumetinib_30min_R1 1 SVSPLLSTHVLGK 13 0 Q96H12;X6RL08;X6R907;Q96H12-2 Q96H12 MSANTD3 Myb/SANT-like DNA-binding domain-containing protein 3 1 S(0.241)VS(0.758)PLLS(0.001)THVLGK 103.66 0.0054971 18937000.0 9614.7 12791.0 10879.0 11447.0 13386.0 12007.0 11581.0 9715.3 3471.2 5126.1 True False 9838.70380305051 11293.423773625422 9401.691554069483 9447.996336802558 12175.23866349025 11886.220481483724 10707.435846083403 9457.618684258066 5890.372873582865 5784.084867442342 1.7009957544763818 1.9524996663161422 1.6254414949874008 1.63344704535436 2.1049550520986746 2.054987219912573 1.8511892704676223 1.6351106356501508 1.0183759416703584 1.0 12.49787300516342 -8.177592671712004 2.787888784912122 0.9758765001576808 1.8495262436240323 0.819285237189431 0.15488886062856505 0.11836764735820889 1.6572789202345415 0.14695074250229287 0.044907475843310084 6.643658923959404e-09 8.177592671712004 0.8736497434663515 SVS(ph)PLVWCR ddPTM_A459_Selumetinib_30min_R1 1 SVSPLVWCR 9 0 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 S(0.001)VS(0.999)PLVWCR 93.556 0.024411 11306000.0 1128.0 1827.8 1918.7 1774.2 1533.3 1678.0 1530.6 1445.3 829.06 1475.2 True False 1154.280205294079 1613.8003262788334 1658.151078664685 1464.3692758587483 1394.6132857261011 1661.1208435020997 1415.1456097068697 1406.9659490039612 1406.8542678533668 1664.5562896648414 0.6934461829022877 0.9695078119609715 0.9961520009627033 0.8797355096676239 0.8378288522804517 0.9979361189621089 0.850163865585951 0.8452498469049995 0.8451827532589102 1.0 10.700921943032844 SVS(ph)PLVWCR ddPTM_A459_Selumetinib_30min_R2 2 SVSPLVWCR 9 0 Q9P270 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 SVS(1)PLVWCR;S(0.001)VS(0.999)PLVWCR 101.97 0.016544999999999997 9366900.0 29179.0 33893.0 30602.0 40973.0 40267.0 26485.0 25724.0 27634.0 27692.0 39300.0 True False 27557.347992791805 36492.48411682824 28633.100636938325 35392.40671763259 35208.29946845261 30133.068343107625 26920.216971138987 27714.410364945034 33231.173779127836 38165.30688633723 0.7220523098336997 0.956169020873042 0.7502389728507244 0.9273450053221685 0.9225210627366082 0.7895408369923245 0.7053583258563063 0.7261676277747027 0.870716797276016 1.0 15.219974171602464 -6.812123016600554 24.99655893139769 0.794179655494521 0.8593741950979809 0.004440215321435348 0.10464269550840159 281.8560326246377 139005.78082698197 0.03543060763002409 0.031246895152503795 1.5412638185947797e-07 6.812123016600554 0.06519453960345989 SVS(ph)PQNSDSSGFADVNGWHLR ddPTM_A459_Selumetinib_30min_R2 1 SVSPQNSDSSGFADVNGWHLR 21 0 S4R3E2;Q9UKB3 S4R3E2 DNAJC12 DnaJ homolog subfamily C member 12 1 S(0.131)VS(0.869)PQNSDSSGFADVNGWHLR 229.06 5.030100000000001e-25 8287900.0 16135.0 9437.4 12852.0 12390.0 14708.0 10696.0 9237.8 12650.0 9683.8 12095.0 True False 15238.281293522594 10161.218233976173 12025.116312199587 10702.460626057846 12860.249548811698 12169.276911379246 9667.376004353433 12686.80940567977 11620.830587979128 11745.785923416004 1.2973402880725136 0.8650947923134806 1.0237813280954422 0.9111745008668837 1.0948819970551258 1.0360547170469865 0.8230505874520391 1.0801158380034641 0.9893616879916252 1.0 13.51985562843642 -4.747818351981224 24.980146203781292 0.9824876718045765 1.2973410724251992 0.5587094824849821 0.08448618157273567 510.38825610884396 935966.9435303718 0.02033613980876703 0.39693466315878034 1.7872349474683514e-05 4.747818351981224 0.3148534006206227 SVS(ph)PQTLEAYIR ddPTM_A459_Selumetinib_30min_R2 1 SVSPQTLEAYIR 12 0 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0 A0A2R8Y7K2 SPAST Spastin 1 S(0.002)VS(0.994)PQT(0.004)LEAYIR 81.278 0.038544 1311300.0 3207.8 2618.0 4258.7 4896.2 5214.7 3844.1 4993.0 3830.9 3321.2 4746.3 True False 3029.5233178408293 2818.7921818032128 3984.6998785219694 4229.329113583892 4559.582765990511 4373.589881734568 5225.184393441806 3842.047284760365 3985.532802081441 4609.261986631612 0.6572686314267776 0.6115495691020916 0.8644984576877861 0.9175718641835393 0.9892218709231136 0.9488698829485998 1.1336271204797153 0.8335493395479745 0.8646791641787357 1.0 12.170320056257747 -5.408241437391885 2.462229807799905 0.9574205518868258 0.6259481267827914 0.7196129883417224 0.07873154501694815 0.15834266098731178 1.8376130258665746 0.022938522469732787 0.06127986436358947 3.90623675943828e-06 5.408241437391885 -0.3314724251040344 SVS(ph)PSPVPLLFQPDQNAPPIR ddPTM_A459_Selumetinib_30min_R1 3 SVSPSPVPLLFQPDQNAPPIR 21 0 Q02241-2;Q02241-3 Q02241-2 KIF23 Kinesin-like protein KIF23 1 S(0.055)VS(0.945)PSPVPLLFQPDQNAPPIR;S(0.009)VS(0.97)PS(0.021)PVPLLFQPDQNAPPIR;S(0.034)VS(0.736)PS(0.23)PVPLLFQPDQNAPPIR 280.01 6.997199999999997e-73 297551000.0 9683.4 15247.7 14875.7 17167.2 14277.7 12735.0 13685.400000000001 11375.4 6255.299999999999 8834.2 True False 9909.004379383581 13462.49219553659 12855.66164637112 14169.270788255171 12986.284555932672 12606.897462454837 12653.09925982125 11073.687439493298 10614.78723096419 9968.155622395032 0.9940659791788806 1.3505499618496104 1.2896730481904648 1.4214536093740022 1.302777068082378 1.2647171593239832 1.2693520987367082 1.1109063560980643 1.0648697344889357 1.0 13.28311087648959 -7.936716357110717 1.7231895266433832 1.018399902768476 1.2853595819170172 0.46778114845583174 0.10507526475538628 0.32682725848905353 1.7744935312874566 0.08822994366695008 0.030549539386614907 1.1568675594685255e-08 7.936716357110717 0.26695967914854113 SVS(ph)PSPVPLLFQPDQNAPPIR ddPTM_A459_Selumetinib_30min_R2 4 SVSPSPVPLLFQPDQNAPPIR 21 0 Q02241-2;Q02241-3 Q02241-2 KIF23 Kinesin-like protein KIF23 1 S(0.064)VS(0.934)PS(0.001)PVPLLFQPDQNAPPIR;S(0.01)VS(0.956)PS(0.034)PVPLLFQPDQNAPPIR;S(0.106)VS(0.888)PS(0.006)PVPLLFQPDQNAPPIR;S(0.028)VS(0.844)PS(0.128)PVPLLFQPDQNAPPIR 239.8 4.784e-31 176040000.0 58051.0 62439.3 65661.2 63962.0 64062.5 45571.899999999994 48191.4 48460.4 46847.2 60043.1 True False 54824.75781656524 67228.19353600663 61436.62987850908 55250.26525939564 56014.39602398356 51849.01556448053 50432.39558944748 48601.411740948904 56217.949020134205 58309.499692290934 0.9402371501365083 1.1529543880633712 1.053629857960033 0.9475345449877054 0.9606392838144895 0.8892035746850261 0.8649087345216087 0.8335076102080579 0.9641301900514634 1.0 15.831443323738274 -5.979707273687799 1.8483784493481898 0.9031118050886122 1.0607285483174076 0.4108226842192778 0.0678826320043085 0.2903028575104372 2.0004047391185624 0.02170101543442838 0.03589573730874266 1.047834579134363e-06 5.979707273687799 0.15761674322879538 SVS(ph)PSPVPLSSNYIAQISNGQQLMSQPQLHR ddPTM_A459_Selumetinib_30min_R1 2 SVSPSPVPLSSNYIAQISNGQQLMSQPQLHR 31 0 Q02241;H7BYN4 Q02241 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 S(0.141)VS(0.627)PS(0.194)PVPLS(0.016)S(0.016)NY(0.005)IAQISNGQQLMSQPQLHR;S(0.044)VS(0.722)PS(0.233)PVPLSSNYIAQISNGQQLMSQPQLHR 134.11 2.5014e-18 44356000.0 3118.1000000000004 4897.1 5579.1 5840.5 5629.6 4334.8 4747.2 4086.7 2083.38 3549.5 True False 3190.745663233572 4323.7452553999765 4821.488863802653 4820.566314763288 5120.403673986604 4291.19584768349 4389.114882007352 3978.307440527561 3535.3436959452265 4005.1129000578594 0.7966680947214939 1.0795563978577267 1.2038334459268303 1.2036031030969558 1.2784667503162352 1.0714294340170778 1.0958779419036966 0.9933071900345404 0.8827076250195478 1.0 11.967627195974687 -7.814810403895647 2.6542692264543097 0.9388231355154233 1.119113751337309 0.22516102570904517 0.12437994875847547 0.4133508564533878 5.787602313731355 0.08678835222040183 0.03686880992775583 1.5317560209287164e-08 7.814810403895647 0.18029061582188577 SVS(ph)PSPVPLSSNYIAQISNGQQLMSQPQLHR ddPTM_A459_Selumetinib_30min_R2 2 SVSPSPVPLSSNYIAQISNGQQLMSQPQLHR 31 0 Q02241;H7BYN4 Q02241 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 S(0.112)VS(0.619)PS(0.194)PVPLS(0.029)S(0.029)NY(0.016)IAQIS(0.001)NGQQLMSQPQLHR;S(0.187)VS(0.581)PS(0.227)PVPLS(0.002)S(0.002)NY(0.001)IAQISNGQQLMSQPQLHR 118.5 4.0129e-16 12399600.0 38593.2 37306.1 38890.9 44625.5 48095.0 30567.8 33477.0 34402.4 33505.8 38181.1 True False 36448.34444482036 40167.35791198196 36388.701835210304 38547.429916718684 42052.876125244715 34778.23698313935 35033.746833417026 34502.50528837608 40207.89623027234 37078.71243658855 0.9829991941374385 1.0832996960365215 0.9813906536652726 1.0396108004732343 1.1341514675614184 0.9379569757881039 0.9448479877323467 0.9305205877194831 1.084393000405159 1.0 15.178303526598109 -6.800496211578126 24.999966364549856 0.9730327697193775 1.042703511744054 0.23015372450720906 0.05857011088175896 229.3038322886611 146774.08173747978 0.020435635630054225 0.01802278325267 1.583083376141703e-07 6.800496211578126 0.06967074202467649 SVS(ph)PTFLNPSDENLK ddPTM_A459_Selumetinib_30min_R1 2 SVSPTFLNPSDENLK 15 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 S(0.01)VS(0.615)PT(0.375)FLNPSDENLK;S(0.015)VS(0.813)PT(0.165)FLNPS(0.007)DENLK 154.47 0.0001876 68427300.0 6492.3099999999995 6356.639999999999 8646.9 8248.7 7192.599999999999 6027.4 7148.18 6912.009999999999 3824.4700000000003 5821.66 True False 6643.568191163832 5612.40163367824 7472.6984740218195 6808.219392275987 6542.030599956671 5966.769828441326 6608.987027567266 6728.68104142729 6489.846261762923 6568.926768770489 1.011362803243324 0.8543863908424598 1.1375828559313488 1.0364279633384141 0.9959055459498063 0.9083325234813253 1.0060984480733182 1.024319691523476 0.9879614266087537 1.0 12.681441966952464 -1.5230435483498628 0.004064877858174255 1.3178940814752846 0.657508514338093 0.00036911646727610936 0.07114878459340103 1375614.0037909718 435.8218025568607 33342.3648685487 37579.22033101604 0.029988617966989158 1.5230435483498628 -0.6603855671371917 SVS(ph)PTFLNPSDENLK ddPTM_A459_Selumetinib_30min_R2 2 SVSPTFLNPSDENLK 15 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 SVS(0.5)PT(0.5)FLNPSDENLK;S(0.037)VS(0.963)PTFLNPSDENLK 248.81 6.0051e-28 58005000.0 83203.0 80281.0 87581.0 95130.0 87583.0 70587.0 77650.0 82835.0 71710.0 90536.0 True False 78578.91034799874 86438.29455589884 81946.13381098266 82173.12989159669 76580.04053804559 80309.71852501182 81260.87886055595 83076.03613592747 86054.00374480926 87921.99043922195 0.8937344338481301 0.9831248601639798 0.9320322868216885 0.9346140764226751 0.8709998506116996 0.9134201594369923 0.9242383896748716 0.944883478193725 0.9787540445219564 1.0 16.42393642694089 -8.245510287298845 1.8222609042180327 0.9989462821567165 0.9226186955072698 0.4955773068923327 0.027392915366071205 0.31116140904198786 1.9061793484712928 0.026864629363865362 0.007987774897159525 5.681849325875431e-09 8.245510287298845 -0.07632758664944672 SVS(ph)PTTEMVS(ph)NESVDYR ddPTM_A459_Selumetinib_30min_R2 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 2 S(0.018)VS(0.911)PT(0.066)T(0.005)EMVS(0.57)NES(0.43)VDYR 115.26 0.030353 3027400.0 16637.0 11138.0 15625.0 20681.0 13844.0 11937.0 29845.0 19455.0 16852.0 12305.0 True False 15712.382143187813 11992.248785685322 14619.704511213698 17864.212123285102 12104.792953069706 13581.21339670288 31232.851636745556 19511.61082905136 20222.8708842215 11949.72267777047 1.3148742081200635 1.0035587527059486 1.223434627349978 1.4949478414689146 1.0129768932284684 1.1365295884202733 2.613688407585108 1.6328086730705413 1.6923297242572157 1.0 13.544689516914655 SVS(ph)PTTEMVSNESVDYR ddPTM_A459_Selumetinib_30min_R1 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 S(0.01)VS(0.953)PT(0.036)T(0.001)EMVSNESVDYR 101.54 0.003943 20402000.0 1330.1 1267.4 1709.2 1456.7 1771.7 1216.6 1654.7 1655.0 664.26 1246.0 True False 1361.0887420759339 1119.0122188017256 1477.1000279635582 1202.3146906456095 1611.4500478190412 1204.3621085844184 1529.8846467933877 1611.104023802362 1127.2007043691385 1405.9362370677832 0.9681013307649121 0.7959196080865903 1.0506166560186214 0.8551701413949994 1.1461757690945338 0.8566264079630188 1.088160761816703 1.145929652657987 0.8017438306590812 1.0 10.457315450514871 -5.631539473178809 1.346529344698216 1.0054653057409677 0.8923104598104631 0.06870479530837725 0.1250830916773776 1.1635698387159883 4.049620667254397 0.039481267470162125 0.11686485948945587 2.3359337787240356e-06 5.631539473178809 -0.11315484593050462 SVS(ph)PTTEMVSNESVDYR ddPTM_A459_Selumetinib_30min_R2 3 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 S(0.003)VS(0.828)PT(0.128)T(0.041)EMVSNESVDYR;SVS(0.997)PT(0.003)TEMVSNESVDYR;S(0.205)VS(0.781)PT(0.013)TEMVSNESVDYR 271.27 1.1150999999999998e-51 38418100.0 75031.0 31924.1 47056.2 62582.0 43522.6 38775.7 67557.0 52261.7 37331.7 39008.1 True False 70861.0773928908 34372.575817839526 44028.655322916726 54058.22364002842 38054.90189101931 44116.70070424159 70698.53436165593 52413.772894609814 44799.083134850014 37881.8347977845 1.8705819760619167 0.9073630145245708 1.1622630096441824 1.4270223163316786 1.004568603769027 1.164587220754728 1.866291185182791 1.383612308495554 1.1826006679452092 1.0 15.209218588644 SVS(ph)SNVASVSPIPAGSK ddPTM_A459_Selumetinib_30min_R2 2 SVSSNVASVSPIPAGSK 17 0 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVS(0.981)S(0.019)NVASVSPIPAGSK;SVS(0.992)S(0.008)NVASVSPIPAGSK 272.31 9.0048e-52 8128900.0 47902.0 37957.0 48935.0 56396.0 54788.0 32557.0 41203.0 52802.0 41493.0 37857.0 True False 45239.79860689925 40868.1798490086 45786.575376399516 48714.767511473605 47905.041629065534 37041.43122697963 43119.02114219561 52955.64507815833 49792.75941128669 36763.9700457015 1.2305471512097685 1.1116367410321881 1.2454197770121662 1.325068197229951 1.303043212403734 1.0075470951840406 1.1728608495925252 1.44042237582962 1.3543901637768996 1.0 15.166004947481676 SVS(ph)SPTSSNTPTPTK ddPTM_A459_Selumetinib_30min_R1 1 SVSSPTSSNTPTPTK 15 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 SVS(0.496)S(0.496)PT(0.005)S(0.001)SNT(0.001)PTPTK 102.63 0.0061729 22780000.0 970.53 1069.9 1095.4 1464.1 1083.5 1005.1 830.35 1126.2 803.21 909.69 True False 993.1414606773608 944.6356106169839 946.6506966014987 1208.4224195608122 985.4976163074621 994.9896065577833 767.7160309813796 1096.329517586841 1362.9887058626678 1026.4575726309715 0.9675426312378247 0.9202870491721687 0.9222501950812099 1.177274591548325 0.9600958116383489 0.9693431400262059 0.7479276800633885 1.0680709527786683 1.3278568371502333 1.0 10.003458281305004 -7.999181072678744 24.99955670406588 1.1752736103820738 0.9556933046510225 0.3310264011749471 0.12205959698839684 27.64326209974181 843884.1692102357 0.06703363265019188 0.03175908219645161 1.00188742879782e-08 7.999181072678744 -0.21958030573105125 SVS(ph)SSSYR ddPTM_A459_Selumetinib_30min_R1 1 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVS(0.443)S(0.443)S(0.112)S(0.002)YR 96.668 0.020892 10089000.0 1756.9 2931.8 2471.0 2300.8 2290.7 2041.9 2122.0 2091.8 1201.8 1608.5 True False 1797.8323516677003 2588.543493043159 2135.4517722314263 1899.0084713650149 2083.5065894559316 2021.3603398968623 1961.935831568 2036.3186688760024 2039.366824000889 1814.9666431167975 0.9905594455335703 1.426220973735317 1.1765790739626307 1.0463048886143134 1.147958612549472 1.1137176253694834 1.0809762476950078 1.1219592804080865 1.1236387355850985 1.0 10.825727318143608 -4.698355481177499 0.03924564581500851 0.5800398094604531 1.800756375766844 0.1422493849605393 0.10794354954712973 697.9537227497078 4.1964420352658385 48.16823736360863 86.28352242590788 2.0028319868748908e-05 4.698355481177499 1.220716566306391 SVS(ph)SSSYR ddPTM_A459_Selumetinib_30min_R2 1 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVS(0.327)S(0.327)S(0.327)S(0.018)YR 96.668 0.020892 40018000.0 220280.0 197400.0 216980.0 222740.0 267760.0 195820.0 151010.0 179380.0 129830.0 277700.0 True False 208037.71945070676 212539.94525895859 203019.74302996197 192402.42775206818 234121.59499522834 222792.42752302575 158032.26422063846 179901.96610204238 155799.62775329195 269682.0794487488 0.7714184045004105 0.7881129724800655 0.7528113972012904 0.7134416500545893 0.8681392381495691 0.8261298933115276 0.5859946813806418 0.6670890645376809 0.5777159093098012 1.0 18.0409001311627 -7.242033028476814 24.9243710899678 0.6799573215961221 0.7855757241997937 0.07991270525011007 0.11697019692657316 1422.1395607614236 1826514.4923121904 0.04227673235937725 0.03269673733365175 5.727524710009624e-08 7.242033028476814 0.10561840260367161 SVS(ph)SYGNIR ddPTM_A459_Selumetinib_30min_R2 1 SVSSYGNIR 9 0 Q8N122;Q8N122-3 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 SVS(0.5)S(0.5)YGNIR 181.87 0.0014625 26126000.0 89976.0 85376.0 127250.0 124670.0 124520.0 107060.0 95916.0 115460.0 84114.0 97312.0 True False 84975.49412246596 91924.06467289204 119062.87353932406 107689.73093225436 108876.684377076 121806.54320608293 100376.28405394846 115795.96948456806 100939.15034152653 94502.34971305965 0.8991892199556902 0.9727172387988644 1.2598932608642883 1.139545537854201 1.152105579466136 1.2889260804194587 1.0621564898515647 1.2253237071476304 1.0681125987661801 1.0 16.52806258059993 -5.101675242835446 5.150486652813118 1.1586129976589545 0.9153636713790061 0.4968298442073197 0.08680613885802341 0.1473906676321611 5.810737053883317 0.020626002055580843 0.05926844990043049 7.9127010357919e-06 5.101675242835446 -0.24324932627994844 SVS(ph)TMNLSK ddPTM_A459_Selumetinib_30min_R2 2 SVSTMNLSK 9 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 SVS(0.908)T(0.092)MNLSK;S(0.003)VS(0.499)T(0.499)MNLSK 99.752 0.018527 38372000.0 135892.0 103076.0 112496.0 128061.0 98817.0 120119.0 83200.0 103615.0 75466.0 78607.0 True False 128339.66665877722 110981.59775842173 105258.12983638364 110618.87088245313 86402.72502481152 136664.3019182837 87068.96485767243 103916.50249561333 90561.30869621779 76337.41166448609 1.681215852888077 1.453829719118613 1.378853795816503 1.4490780925169298 1.1318529557245656 1.790266383656587 1.1405805221737548 1.3612788307827532 1.1863293072372925 1.0 16.220102650172663 -9.050491076897838 0.05556719555138365 6.251832529515892e-10 2.4035916209678923 0.4206290710743882 0.18097323912128055 76.78544157373693 1.7950846033462264 43.560103660654285 32.93237314192147 8.902437289498081e-10 9.050491076897838 2.403591620342709 SVS(ph)TPSEAGSQDSGDGAVGSR ddPTM_A459_Selumetinib_30min_R1 1 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 SVS(0.495)T(0.495)PS(0.009)EAGSQDSGDGAVGSR 237.39 6.5611e-31 4694600.0 831.92 963.95 874.19 1000.8 1044.3 714.47 937.97 981.38 294.04 707.2 True False 851.3021173654698 851.0902858718025 755.4797995819471 826.0290673427098 949.8432493861394 707.2830804868557 867.2181677360211 955.3506144284971 498.9644041680989 797.9760087113456 1.0668267066578114 1.0665612456773372 0.9467450040283469 1.0351552657286869 1.190315547105288 0.8863462970886178 1.086772231581868 1.1972172145517213 0.625287475714813 1.0 9.640201561994939 -8.254930700387744 24.989394045273695 0.8126437350006102 1.054657135123117 0.392505794491401 0.12272181609964675 454.29727727798144 1744243.9441760862 0.082679539302335 0.02960568756222007 5.559929690198013e-09 8.254930700387744 0.24201340012250694 SVS(ph)TPSEAGSQDSGDGAVGSR ddPTM_A459_Selumetinib_30min_R2 1 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 S(0.326)VS(0.539)T(0.059)PS(0.075)EAGSQDSGDGAVGSR 266.28 6.1889e-50 9822000.0 14510.0 13643.0 17556.0 16705.0 17338.0 14104.0 11855.0 11883.0 11039.0 14350.0 True False 13703.592288132184 14689.374230840811 16426.466073527536 14429.750182267666 15159.845436313382 16046.697976635456 12406.28099023685 11917.577562663442 13247.108455430884 13935.678214222373 0.9833459181158957 1.0540839136088287 1.1787345991358449 1.0354537440123335 1.087844107999111 1.1514831018599894 0.8902531186157369 0.8551846117184801 0.9505894332370022 1.0 13.766495596019546 -7.271203949874417 24.8747775598662 0.9119388302000246 1.0831342057838083 0.5976172371984534 0.06312542805273434 427.6770900874162 1089481.9639872208 0.026250364652928557 0.017948589896566235 5.3554510007707703e-08 7.271203949874417 0.17119537558378362 SVS(ph)TTNIAGHFNDESPLGLR ddPTM_A459_Selumetinib_30min_R1 3 SVSTTNIAGHFNDESPLGLR 20 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 S(0.011)VS(0.853)T(0.133)T(0.002)NIAGHFNDESPLGLR;S(0.178)VS(0.588)T(0.178)T(0.056)NIAGHFNDESPLGLR;S(0.142)VS(0.716)T(0.142)T(0.001)NIAGHFNDESPLGLR 167.88 1.8813e-09 80978100.0 2833.74 3101.29 3031.44 3168.71 3364.2 3037.2200000000003 3387.75 2356.41 1466.38 2743.4700000000003 True False 2899.7606285018114 2738.189525049394 2619.7870985079867 2615.3542825534755 3059.9087039977526 3006.668324375117 3132.2092900068264 2293.9103521015863 2488.3397598422553 3095.6210981607965 0.9367298311232755 0.8845363945465536 0.8462880357239078 0.8448560723750519 0.9884635770882096 0.9712649672020491 1.0118193379247118 0.7410178052683737 0.803825688266776 1.0 11.596013182094927 -11.031723095187067 2.8532784141141936 1.0042261369523806 0.8933720977039843 0.13527579245288035 0.08179150624113814 50624328.83096168 55305408.298035696 1671729.126422412 0.021789226707168836 9.295588817295829e-12 11.031723095187067 -0.11085403924839632 SVS(ph)TTNIAGHFNDESPLGLR ddPTM_A459_Selumetinib_30min_R2 3 SVSTTNIAGHFNDESPLGLR 20 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 S(0.155)VS(0.653)T(0.155)T(0.037)NIAGHFNDESPLGLR;S(0.013)VS(0.964)T(0.016)T(0.007)NIAGHFNDESPLGLR;S(0.073)VS(0.701)T(0.204)T(0.022)NIAGHFNDESPLGLR 115.2 0.00017987 38562700.0 35484.6 35909.5 25502.6 36157.2 34166.3 35542.9 27964.6 26116.699999999997 31620.8 35968.0 True False 33512.50798810859 38663.643182758766 23861.790481131407 31232.52698535097 29874.02394340259 40438.61184867813 29265.009310803645 26192.695273147554 37945.84355897174 34929.51038391292 0.9594325147925078 1.1069048136605324 0.6831412813653739 0.8941587397610753 0.8552660376585559 1.157720546443802 0.8378305046119939 0.7498729580020342 1.0863548656109425 1.0 15.09215879979006 SVS(ph)VDESRPELIFR ddPTM_A459_Selumetinib_30min_R1 1 SVSVDESRPELIFR 14 1 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 1 S(0.027)VS(0.973)VDESRPELIFR 76.82 0.022788 5111800.0 1342.3 1375.0 1454.8 1552.7 1336.4 1390.8 1279.4 1146.5 864.65 1309.0 True False 1373.572978338867 1214.0143607798416 1257.246150644386 1281.5500927887945 1215.5228559605835 1376.8098147453636 1182.8938279491515 1116.0910956431474 1467.2478984626139 1477.0229007397497 0.9299605156094255 0.8219333364241114 0.8512028825109678 0.8676575645150424 0.8229546443401812 0.9321519754743169 0.8008635664055803 0.7556356066545523 0.993381956182101 1.0 10.52847647943611 -8.292562140370416 21.38996264330722 0.996691908126752 0.8481281735715482 0.5744394894861775 0.05126205156981738 94.70624504519185 65085.4789679027 0.04879991232862199 0.012614726805018801 5.098446420045876e-09 8.292562140370416 -0.14856373455520377 SVS(ph)VDIR ddPTM_A459_Selumetinib_30min_R1 2 SVSVDIR 7 0 Q6UB99 Q6UB99 ANKRD11 Ankyrin repeat domain-containing protein 11 1 S(0.001)VS(0.999)VDIR;S(0.052)VS(0.948)VDIR 96.034 0.023406 7820000.0 14675.8 19061.5 17580.800000000003 19727.1 18892.9 16510.8 18804.8 18804.300000000003 8720.2 14583.3 True False 15017.717585864213 16829.770718549058 15193.4239244218 16282.132308529559 17184.040530812406 16344.716342606951 17386.33879616866 18305.54887902525 14797.542501791104 16455.208608371267 0.9126421878495202 1.0227625257808788 0.9233200432775092 0.9894819747375515 1.0442918676868282 0.9932852710412856 1.0565857419348483 1.1124470867973475 0.8992619208888754 1.0 14.006256695671695 -6.009114423128249 7.241348226126615 1.0234627765124145 0.9591905410486362 0.1931077357357578 0.05816641138529015 0.21967434408243228 71.36551207410241 0.01622414164087773 0.02252359361141046 9.792319541652237e-07 6.009114423128249 -0.06427223546377825 SVS(ph)VDSGEQR ddPTM_A459_Selumetinib_30min_R1 1 SVSVDSGEQR 10 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 S(0.003)VS(0.886)VDS(0.111)GEQR 132.03 0.0036558 0.0 788.35 1312.6 1116.8 1285.9 1264.2 1114.7 1537.4 1509.4 1201.2 888.83 True False 806.7170211379319 1158.920181788815 965.1446941432845 1061.3417043325253 1149.8533332126378 1103.4871300666214 1421.4326802321598 1469.3658087778165 2038.3486678231545 1002.9199884373651 0.8043682750753286 1.155546000827555 0.9623346879815031 1.0582516218329503 1.1465055502624966 1.100274341710896 1.4172941975629314 1.465087769431352 2.0324140423196426 1.0 9.969990798998005 -7.312806137453821 1.7560725153297323 1.5635633579100525 1.0269439558857603 0.42650251113199167 0.2507402637833732 0.3225928241252775 1.937326805325851 0.13206104987490289 0.07818261282341152 4.866243790441722e-08 7.312806137453821 -0.5366194020242923 SVS(ph)VVTGSEQKR ddPTM_A459_Selumetinib_30min_R2 1 SVSVVTGSEQKR 12 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 S(0.008)VS(0.992)VVTGSEQKR 63.212 0.043826 2293800.0 22680.0 19720.0 22945.0 25736.0 22592.0 18720.0 16793.0 24661.0 15830.0 21784.0 True False 21419.536395233506 21232.46059020601 21468.743680627096 22230.712402923713 19753.790984957446 21298.510076759474 17573.90777469822 24732.75942715166 18996.442327155626 21155.039318370746 1.0125027929696673 1.0036597082458756 1.0148288243541073 1.0508471323718538 0.9337629057396043 1.0067818715072838 0.8307196933185219 1.1691190479458988 0.8979629884525611 1.0 14.36871374661293 -6.2528059330035655 24.782102451469566 0.9760830061679207 1.0188574180261611 0.07156726149509662 0.08313392953347876 1824.3812199715237 5236836.06437272 0.023567652193039346 0.029950709642928112 5.587198061334086e-07 6.2528059330035655 0.04277441185824049 SVSCDNVS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 SVSCDNVSK 9 0 Q96CB8;A0A087WXN4 Q96CB8 INTS12 Integrator complex subunit 12 1 S(0.317)VS(0.213)CDNVS(0.47)K 105.17 0.013905 57135000.0 2987.4 3653.0 3131.9 3784.4 3795.7 2902.9 3591.5 3288.0 1768.7 2878.8 True False 3057.0006075314973 3225.3050617663716 2706.6051822952654 3123.525581986161 3452.379605185264 2873.699461622315 3320.5902634667614 3200.7915590707985 3001.354719263082 3248.322021886625 0.9411014631351087 0.9929142000192195 0.8332317929252807 0.961581259782864 1.0628193824145928 0.8846719759493767 1.0222478686205387 0.9853676875335713 0.9239708067859281 1.0 11.665478945618098 -5.987404128347309 24.9960605302086 0.9797237077653629 0.9241224728027396 0.16003076171713349 0.05880569628865191 430.24398293874646 853796.1776916181 0.01616992791893608 0.023966613429571 1.029427751005378e-06 5.987404128347309 -0.05560123496262326 SVSCS(ph)DEDEKPR ddPTM_A459_Selumetinib_30min_R1 2 SVSCSDEDEKPR 12 1 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 SVS(0.456)CS(0.544)DEDEKPR;S(0.026)VS(0.01)CS(0.964)DEDEKPR 149.57 0.002718 8084800.0 2387.26 2525.5 3001.2 3117.3999999999996 2681.0 2494.2 2466.8999999999996 2348.6 1565.44 2083.0 True False 2442.8785132006597 2229.813285926902 2593.6535244115553 2573.004610845489 2438.504023368994 2469.1106125524047 2280.8197468874155 2286.307498672041 2656.437344786113 2350.373340138195 1.039357650753912 0.9487059982546414 1.103507038698395 1.0947216626845349 1.0374964614028581 1.0505184731236052 0.9704074275933159 0.9727422701865794 1.1302193142770767 1.0 11.198674221531515 -10.726150204095028 14.518594582690312 0.9999993744981995 1.0359155349929225 0.037209985368559906 0.05747629504905948 0.0 0.0 0.05662329207137409 0.013733165534145554 1.878666952979109e-11 10.726150204095028 0.035916160494723015 SVSCS(ph)DEDEKPR ddPTM_A459_Selumetinib_30min_R2 1 SVSCSDEDEKPR 12 1 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 SVS(0.002)CS(0.998)DEDEKPR 142.39 0.0043316000000000006 3260600.0 14242.0 12390.0 14077.0 14696.0 14666.0 9192.8 13722.0 11800.0 8781.3 11482.0 True False 13450.486655243185 13340.27315987082 13171.301145878731 12694.37944798597 12823.525964296468 10459.024756070216 14360.100189627174 11834.33604640484 10537.805370022208 11150.484826181273 1.2062692219141469 1.1963850332810584 1.181231251483576 1.1384598648284459 1.1500420084144596 0.9379883403376763 1.2878453639889937 1.0613292812719577 0.9450535590416215 1.0 13.444818819840403 -6.2592465788559375 0.2346116379403499 0.9686510302502453 1.304554527731044 0.3621692233617816 0.0900409023842052 6.298234325754787 0.5912188038530478 0.18107313219311058 0.6354669583393828 5.504950537444977e-07 6.2592465788559375 0.3359034974807986 SVSEINS(ph)DDELSGK ddPTM_A459_Selumetinib_30min_R1 1 SVSEINSDDELSGK 14 0 F8WF45;A0A2R8Y7M0;P82094;P82094-2 F8WF45 TMF1 TATA element modulatory factor 1 S(0.133)VS(0.068)EINS(0.799)DDELSGK 295.22 3.3542999999999986e-67 61025000.0 3251.4 3764.6 3550.8 4188.7 3681.8 3219.2 3231.4 3231.9 1522.6 2471.4 True False 3327.15129387692 3323.838881884941 3068.6208631482605 3457.2221766371003 3348.7818400745855 3186.817770799736 2987.652896384934 3146.179513309278 2583.7409936959166 2788.628263474573 1.1931139540740932 1.1919261256226052 1.1004051358659122 1.2397572749009842 1.2008706516881074 1.1427904581405293 1.0713700838212048 1.128217609538678 0.9265275790028137 1.0 11.44533991419292 -7.804407956856105 1.0737879329978577 0.9727503779718228 1.1820059097001077 0.7074217582326666 0.050326177216500304 0.2835971298198939 0.5907397772728192 0.04353833980907396 0.017001738518483304 1.5688883682100602e-08 7.804407956856105 0.20925553172828482 SVSENS(ph)LVAMDFSGQTGR ddPTM_A459_Selumetinib_30min_R2 1 SVSENSLVAMDFSGQTGR 18 0 A0A2R8YCL1;Q13322-3;Q13322-2;Q13322-4;Q13322 A0A2R8YCL1 GRB10 Growth factor receptor-bound protein 10 1 SVS(0.016)ENS(0.984)LVAMDFSGQTGR 97.502 0.0034997 9455800.0 10893.0 7169.6 9760.5 9174.6 12226.0 6703.6 10402.0 7756.6 6379.0 10635.0 True False 10287.610668133973 7719.485266102486 9132.520056428888 7925.003652932226 10690.06057817323 7626.960050778041 10885.713611171974 7779.170421825742 7654.97824415197 10327.939916951558 0.9960951313483736 0.7474370811774633 0.8842537940639458 0.7673363436133743 1.0350622354635615 0.7384783521309687 1.0540062876726195 0.7532160803005404 0.7411912061559948 1.0 13.334264892417167 -4.723617800425201 23.78812637799757 0.8561030551384896 0.9960974823142686 0.1026679322432853 0.12247642098481033 8972.622849731295 5642731.46779148 0.028556160281328423 7.282798372401247 1.8896536016241135e-05 4.723617800425201 0.13999442717577903 SVSGS(ph)PEPAAK ddPTM_A459_Selumetinib_30min_R1 4 SVSGSPEPAAK 11 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 SVS(0.027)GS(0.973)PEPAAK;S(0.021)VS(0.07)GS(0.908)PEPAAK;SVS(0.319)GS(0.681)PEPAAK;S(0.036)VS(0.224)GS(0.739)PEPAAK 166.04 0.00061787 224733000.0 26690.600000000002 28688.700000000004 32071.7 34329.899999999994 29607.9 24959.399999999998 28002.199999999997 24580.0 14461.5 22731.2 True False 27312.439049133114 25329.813666985207 27716.539297237825 28334.82741703488 26929.870672699297 24708.33109732197 25889.971509299437 23928.058552907594 24540.10927382997 25648.970940638188 1.0648551597779436 0.9875567220848105 1.0806101874958183 1.1047159545937661 1.0499396149274611 0.9633264100344131 1.009396110636135 0.9329052073194881 0.956767791215696 1.0 14.64661332434397 -6.734129171813763 6.548334365877919 0.9704875996532979 1.0580032282626988 0.6054420651215202 0.034330054053373964 0.1263622946490048 17.76924385807625 0.012173437480578473 0.011866209148363371 1.8444667395178283e-07 6.734129171813763 0.08751562860940088 SVSGS(ph)PEPAAK ddPTM_A459_Selumetinib_30min_R2 5 SVSGSPEPAAK 11 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 SVS(0.027)GS(0.973)PEPAAK;S(0.329)VS(0.055)GS(0.616)PEPAAK;S(0.183)VS(0.11)GS(0.707)PEPAAK;SVS(0.021)GS(0.979)PEPAAK;SVS(0.004)GS(0.996)PEPAAK 174.21 0.00014524 216506400.0 699645.0 684366.0 711988.0 739816.0 755329.0 501815.0 578059.0 566662.0 514105.0 653203.0 True False 660761.5318008441 736854.6716164758 666179.4672339224 639051.7845462145 660437.818293065 570935.4612269799 604939.8889021779 568310.8926040562 616940.3652938938 634343.3321647883 1.0416465316123051 1.1616022968222157 1.0501875458523207 1.0074225614784316 1.0411362188347209 0.9000417160192732 0.953647430702445 0.8959042584472562 0.9725653822016158 1.0 19.274904370862664 -6.12405457240172 1.1262002887528566 0.9404501739978173 1.100262778121212 0.5984846346834853 0.047327628079247855 0.3076727216100944 0.8020169750865715 0.018598829024652038 0.032229525533071346 7.515284528239745e-07 6.12405457240172 0.1598126041233947 SVSGS(ph)PESDELQELR ddPTM_A459_Selumetinib_30min_R1 1 SVSGSPESDELQELR 15 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 S(0.016)VS(0.346)GS(0.638)PESDELQELR 246.66 7.700099999999998e-28 4764200.0 692.65 1364.3 1201.0 1151.1 1050.3 1123.0 1161.8 825.4 342.84 630.5 True False 708.7873973377158 1204.567121754137 1037.9107966207787 950.0819938231353 955.3005504455253 1111.703639602418 1074.1644906294532 803.5077107229431 581.7744399571184 711.4308165900777 0.996284362174481 1.6931612936415734 1.458906154214032 1.3354524033368758 1.3427877007413414 1.562630706568022 1.5098650010382957 1.1294249447531588 0.817752656183199 1.0 9.474579657819088 -7.95737056469401 3.949890297245593 0.9193945750581681 1.4252813276889107 0.5701328365693961 0.17804902116736698 0.14614324106323412 4.803841472842919 0.10947354855988074 0.04590712857875597 1.1031369591740042e-08 7.95737056469401 0.5058867526307426 SVSGS(ph)PESDELQELR ddPTM_A459_Selumetinib_30min_R2 2 SVSGSPESDELQELR 15 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 SVS(0.009)GS(0.958)PES(0.034)DELQELR;SVS(0.055)GS(0.889)PES(0.055)DELQELR 137.39 0.00040182 8664700.0 16778.4 15036.8 22680.0 20093.9 23497.5 17399.6 17775.4 14843.3 17475.9 19238.2 True False 15845.923697256876 16190.074209067432 21220.793492116914 17357.076156089082 20545.53397968472 19796.23696215729 18601.991321286903 14886.491545559405 20971.568317444024 18682.743179153505 0.8481583001653635 0.8665790699907799 1.1358499813772212 0.9290432346924501 1.0997064929206832 1.0596001225476481 0.9956777301335114 0.7968043773234534 1.1225101215781002 1.0 14.189418680442987 -5.117238304349161 8.811820914282908 1.0105703350200992 0.8528488020947433 0.3085789011819735 0.09554235545845328 0.36290781657805204 24.700176466065514 0.02397858998988373 0.06393390641458013 7.634167696001664e-06 5.117238304349161 -0.15772153292535585 SVSMLSLNT(ph)PNSNR ddPTM_A459_Selumetinib_30min_R1 1 SVSMLSLNTPNSNR 14 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3;H7C3G1 Q9H8V3-2 ECT2 Protein ECT2 1 SVSMLSLNT(0.92)PNS(0.08)NR 225.21 2.6815e-09 24543000.0 1143.9 969.56 1065.7 1203.0 839.41 833.65 1046.0 921.99 400.32 702.04 True False 1170.5506443580646 856.0434644637849 920.9837934710764 992.9186331067941 763.4855137098726 825.2642378936382 967.099377860569 897.5358301544056 679.3138017840206 792.1536724486889 1.4776812695189343 1.080653280085922 1.1626327384485267 1.2534419363827536 0.9638098518811409 1.0417981593679906 1.2208481908202125 1.1330324675261072 0.8575530549320562 1.0 9.629636520299135 -2.58326793492626 1.3959932155636512 1.0831017716356917 199.99999961469774 0.5066098914226771 0.11610738361710171 651.3994744444534 3.2952776515287265 0.03349368744116073 412887.5601209459 0.0026105502968390972 2.58326793492626 198.91689784306206 SVSMLSLNT(ph)PNSNR ddPTM_A459_Selumetinib_30min_R2 2 SVSMLSLNTPNSNR 14 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3;H7C3G1 Q9H8V3-2 ECT2 Protein ECT2 1 SVS(0.003)MLS(0.051)LNT(0.946)PNSNR;S(0.052)VS(0.048)MLS(0.064)LNT(0.828)PNS(0.009)NR 158.31 0.00071738 23566000.0 56499.0 45729.0 60517.0 66872.0 63796.0 62588.0 53848.0 57648.0 44099.0 56104.0 True False 53359.01176341697 49236.26725808981 56623.40210592766 57763.91823936565 55781.376136523795 71208.92888270415 56352.03869778773 57815.74613585987 52920.03222901044 54484.13174430188 0.979349584092389 0.9036808641671911 1.0392640993466784 1.0601970957425928 1.0238095818120032 1.3069663882484719 1.034283504089816 1.061148343286326 0.9712925678501793 1.0 15.733548492242159 -5.428226509931602 3.873233568776114 1.0739323621089454 0.942255018298832 0.2291134628166086 0.08822216718866911 0.3196238890182408 8.596839151340504 0.024304941253842898 0.05368824766747034 3.730555368011541e-06 5.428226509931602 -0.13167734381011342 SVSMLSLNTPNS(ph)NR ddPTM_A459_Selumetinib_30min_R2 1 SVSMLSLNTPNSNR 14 0 Q9H8V3-2;Q9H8V3-4;Q9H8V3;Q9H8V3-3;H7C3G1 Q9H8V3-2 ECT2 Protein ECT2 1 SVSMLSLNT(0.001)PNS(0.999)NR 122.75 0.0020237 0.0 13698.0 13495.0 16453.0 12707.0 13615.0 12974.0 10712.0 13772.0 9205.7 13181.0 True False 12936.719997438644 14530.02310673582 15394.431892671932 10976.284679202337 11904.56198035568 14761.050733754142 11210.129225425322 13812.074239922673 11047.097228748988 12800.430281649134 1.010647276129842 1.1351198973026908 1.202649563643309 0.8574934152751165 0.9300126416392593 1.1531683239520298 0.8757619063396885 1.0790320275189378 0.8630254597446034 1.0 13.643904686240965 -5.754405847270172 24.99999380706636 0.9713940073862696 1.1180369962454288 0.3215624422352671 0.10000244007926479 198.12645424510777 704212.9405413878 0.02666310117077187 0.04495384220398175 1.7603302526567916e-06 5.754405847270172 0.14664298885915927 SVSPS(ph)PVPLLFQPDQNAPPIR ddPTM_A459_Selumetinib_30min_R2 1 SVSPSPVPLLFQPDQNAPPIR 21 0 Q02241-2;Q02241-3 Q02241-2 KIF23 Kinesin-like protein KIF23 1 S(0.037)VS(0.385)PS(0.578)PVPLLFQPDQNAPPIR 181.6 2.0609e-14 103350000.0 32003.0 18444.0 21573.0 31849.0 28048.0 17293.0 24197.0 32206.0 22918.0 24410.0 True False 30224.401378159502 19858.595493192686 20185.016666906435 27511.11125741052 24524.359487698588 19674.953779775733 25322.208445445896 32299.71412800968 27502.240382422784 23705.21987520336 1.275010379033669 0.8377309131802485 0.8515009256683082 1.1605507732998621 1.034555242128426 0.8299840239135073 1.0682123422079697 1.3625570358786894 1.1601765571974831 1.0 14.53291715423765 -7.531892478831334 24.857970302077344 1.1998970817066268 0.9896054526253207 0.19372836552865014 0.15757897032663143 257.6889068166648 710639.9838792541 0.07244579698062642 0.04190413434265172 2.9383770354301702e-08 7.531892478831334 -0.21029162908130605 SVSPTFLNPS(ph)DENLK ddPTM_A459_Selumetinib_30min_R1 1 SVSPTFLNPSDENLK 15 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 SVS(0.017)PT(0.085)FLNPS(0.898)DENLK 99.788 0.008009100000000002 63033000.0 8722.9 9621.8 10213.0 10118.0 9811.0 8819.1 9651.2 9125.3 4969.2 8167.1 True False 8926.126598191237 8495.275182946532 8826.130695993344 8351.081238382829 8923.596782272734 8730.387861102121 8923.202213774302 8883.267400848155 8432.36946399169 9215.426839290762 0.9686069624180544 0.9218536841642754 0.9577560377737883 0.9062066667142621 0.9683324427498263 0.9473666291700527 0.9682896266648731 0.9639561526302378 0.9150275522821755 1.0 13.169835274681565 SVSPTFLNPS(ph)DENLK ddPTM_A459_Selumetinib_30min_R2 1 SVSPTFLNPSDENLK 15 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 1 S(0.002)VS(0.063)PT(0.428)FLNPS(0.507)DENLK 128.81 0.00093772 18992000.0 40712.0 36289.0 47189.0 45262.0 46523.0 28564.0 38030.0 44567.0 30900.0 42177.0 True False 38449.39002304876 39072.249612473934 44152.91111549846 39097.23751869492 40678.364819103015 32498.431721824683 39798.470355015386 44696.68259153596 37080.86341813701 40959.24042099353 0.9387232191772202 0.9539300341235717 1.077971921883298 0.9545401017411387 0.9931425583335146 0.7934334569634186 0.9716603615192241 1.0912478388790339 0.9053113055077879 1.0 15.321901340711904 -11.191946301790136 2.9097922923239223 1.0035981889516787 0.9669355491215965 0.016751201581176378 0.07969379035091112 102732520.47279602 72700212.44871078 2673498.928649516 0.020967964799229036 6.4276718715835996e-12 11.191946301790136 -0.03666263983008222 SVSPTTEMVS(ph)NESVDYR ddPTM_A459_Selumetinib_30min_R1 2 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 SVSPTTEMVS(1)NESVDYR;SVSPTTEMVS(0.999)NESVDYR 226.74 3.411e-16 9207400.0 1021.3900000000001 1047.35 1197.92 1100.05 1197.8000000000002 782.47 862.04 1008.36 480.15999999999997 786.6500000000001 True False 1045.1863997210273 924.7257751001947 1035.2490437035494 907.9469179959508 1089.4592014887662 774.599062225916 797.0156287676144 981.6150171851064 814.7964505011371 887.6241901198805 1.177510044628084 1.041798753789375 1.1663145903715524 1.0228956444656219 1.2273879121541589 0.8726655614481399 0.897920130657966 1.1058903397535071 0.9179520562537762 1.0 9.793805175122223 -6.765782880962372 24.99999819820595 0.9616934278356529 1.1188183226989261 0.5058611183342914 0.08293832431391537 99.36335500794256 571904.0655848382 0.02802482473046796 0.02557545955901693 1.714814389081557e-07 6.765782880962372 0.1571248948632732 SVSPTTEMVS(ph)NESVDYR ddPTM_A459_Selumetinib_30min_R2 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 SVSPTTEMVS(0.988)NES(0.012)VDYR 212.35 2.2326e-09 3524400.0 11346.0 5754.0 6910.5 10362.0 7756.2 8562.5 10244.0 8795.5 7760.9 6269.1 True False 10715.434741636653 6195.313297973906 6465.885953583507 8950.677724552977 6781.7968146922285 9741.906652363949 10720.366298100907 8821.093448826585 9313.296857664054 6088.094793922053 1.7600637152256937 1.0176111752003094 1.0620540862863397 1.4701935543922109 1.11394402423936 1.6001568605813459 1.7608737480243253 1.4489086894036167 1.5297555594833752 1.0 12.571775106981955 -6.7712906839303715 24.999143859150387 1.5143042006187417 1.2678587951975986 0.08735171562204425 0.27369065041790597 381.38464993663507 967814.1704822948 0.092723217040528 0.08275614916147062 1.6932041181148837e-07 6.7712906839303715 -0.24644540542114313 SVSPTTEMVSNES(ph)VDYR ddPTM_A459_Selumetinib_30min_R2 1 SVSPTTEMVSNESVDYR 17 0 P08581;P08581-2 P08581 MET Hepatocyte growth factor receptor 1 SVSPTTEMVS(0.485)NES(0.515)VDYR 152.94 0.00014836 4802700.0 11063.0 4103.2 7368.1 10191.0 9087.3 6528.4 10379.0 9392.2 8716.8 5927.8 True False 10448.162748697887 4417.902246132521 6894.04446778071 8802.968219544426 7945.672132507246 7427.6278410852865 10861.644065598339 9419.529747037594 10460.403567741634 5756.649011725952 1.8149730385534364 0.7674433923509175 1.1975794344484008 1.5291827244657965 1.3802599596262313 1.290269360865262 1.8867997759588635 1.636286966228195 1.8170994178096345 1.0 12.491013537132106 -7.230318605490484 24.112291755092002 1.6380704830168298 1.3097085297470674 0.11316554849052496 0.3341400511455355 737.6859921998965 571557.5186247501 0.1230465162987953 0.0952983851475567 5.8841182849655106e-08 7.230318605490484 -0.32836195326976236 SVSS(ph)DSLGPPRPAPAR ddPTM_A459_Selumetinib_30min_R1 2 SVSSDSLGPPRPAPAR 16 1 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 1 SVS(0.123)S(0.874)DS(0.003)LGPPRPAPAR;SVS(0.299)S(0.7)DS(0.001)LGPPRPAPAR 137.73 0.0019297 12391900.0 4609.1 4627.6 5482.1 5123.1 6070.4 4094.1 4615.5 4551.4 2317.3 4385.8 True False 4716.483062252604 4085.7984406871237 4737.660931019791 4228.446757497442 5521.333391816165 4052.917071145375 4267.349119039632 4430.682086969228 3932.288851104391 4948.760151309697 0.9530635791682851 0.8256206233001231 0.9573430083828092 0.8544456850224147 1.1157003417017364 0.8189762581386701 0.8623067169481372 0.8953115429925699 0.7946008153302206 1.0 12.272851406296926 SVSS(ph)PTSSNTPTPTK ddPTM_A459_Selumetinib_30min_R1 1 SVSSPTSSNTPTPTK 15 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 SVS(0.088)S(0.902)PT(0.009)SSNTPTPTK 196.18 3.2274e-05 22705000.0 3088.1 3191.8 3214.1 3690.2 3559.3 2689.5 2616.5 2824.1 1630.6 2516.5 True False 3160.0467216034076 2818.102572172435 2777.6428737875467 3045.775843633161 3237.361943445456 2662.4460718706177 2419.1352984437663 2749.195694030363 2767.0091056880087 2839.5172877857763 1.1128816630898475 0.9924583253268233 0.9782095308014559 1.072638598375368 1.140109960721498 0.9376403811039176 0.8519530093546924 0.9681912154069522 0.9744646097385417 1.0 11.471429979987771 -6.797441751683132 24.72977593407706 0.9385556058250621 1.0517889211248137 0.47619936687554976 0.05860518457910699 146.8740654502071 100885.6726281985 0.021720863985398433 0.01915665383919762 1.5942566908009618e-07 6.797441751683132 0.11323331529975156 SVSS(ph)PTSSNTPTPTK ddPTM_A459_Selumetinib_30min_R2 4 SVSSPTSSNTPTPTK 15 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 SVS(0.052)S(0.945)PT(0.002)SSNTPTPTK;SVS(0.06)S(0.903)PT(0.027)S(0.004)S(0.005)NTPTPTK;S(0.001)VS(0.026)S(0.972)PT(0.002)SSNTPTPTK;SVS(0.026)S(0.962)PT(0.009)S(0.003)S(0.001)NTPTPTK 212.03 8.409200000000002e-07 87870500.0 191690.0 179684.0 208431.0 206371.0 220354.0 162484.0 191249.0 180921.0 156226.0 186065.0 True False 181036.63719586915 193465.18502487728 195020.7763825139 178262.91379016778 192671.16053024575 184864.69611710418 200142.4574527042 181447.45015691617 187475.5653191547 180692.81999507226 1.0019027717914097 1.0706855149537948 1.079294552975776 0.9865522813525698 1.066291181550546 1.02308822299716 1.1076392380071458 1.0041763151511194 1.0375374368736257 1.0 17.46317965488778 -8.45508061159681 1.516772542542675 1.0028437196336142 1.0461263837400363 0.106372036198631 0.03683505401826502 0.8398268063508767 4.203499966843527 0.033487445620104056 0.00992719174464479 3.5068677516388557e-09 8.45508061159681 0.04328266410642212 SVSS(ph)SSYR ddPTM_A459_Selumetinib_30min_R1 1 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVS(0.069)S(0.456)S(0.456)S(0.018)YR 94.309 0.022841 44975000.0 2775.1 6928.3 4569.4 6450.1 5848.8 5195.8 5323.7 4199.2 1611.4 3663.8 True False 2839.754430595388 6117.131415120717 3948.9005779175527 5323.711118372519 5319.777072689507 5143.53496940894 4922.12902286454 4087.8235750760614 2734.4281080005258 4134.084418434146 0.6869125405211228 1.4796822696324339 0.9552055977157006 1.2877606211024022 1.2868090087779247 1.2441775369834225 1.190621314097132 0.9888098938783629 0.66143499532993 1.0 12.013352133709146 -7.951313366989265 3.9194653875246757 0.8256944790471041 1.1776756545904459 0.2725663345340169 0.2165823028952874 0.24760036813770095 7.870757323250668 0.1276294047772318 0.05377867524431053 1.1186304397498001e-08 7.951313366989265 0.35198117554334174 SVSS(ph)YGNIR ddPTM_A459_Selumetinib_30min_R1 3 SVSSYGNIR 9 0 Q8N122;Q8N122-3 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 SVS(0.13)S(0.87)YGNIR;SVS(0.13)S(0.87)YGNIR;SVS(0.044)S(0.956)YGNIR 150.15 0.00045868 69364000.0 8126.6 11534.4 11659.6 11955.5 12290.1 9747.9 10364.0 10240.2 5444.3 8557.6 True False 8315.93396838906 10183.947085802913 10076.290361598361 9867.696357529743 11178.462624993384 9649.84497638505 9582.235135895726 9968.596631142573 9238.579464060613 9656.051318082875 0.8612147651717448 1.0546699422290196 1.0435207964075859 1.0219183838688306 1.1576639618784432 0.9993572588324792 0.9923554484379227 1.0323678181447105 0.9567657792745505 1.0 13.237217628127322 -4.756774381710824 24.899760902430085 1.0319700623890755 0.8612144931574628 0.4931712213984206 0.05085227950965345 116.48492087014286 621667.8393985342 0.012863825096884619 0.10065908571201557 1.750755979440223e-05 4.756774381710824 -0.17075556923161272 SVSS(ph)YGNIR ddPTM_A459_Selumetinib_30min_R2 3 SVSSYGNIR 9 0 Q8N122;Q8N122-3 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 SVS(0.353)S(0.647)YGNIR;S(0.001)VS(0.035)S(0.964)YGNIR;SVS(0.042)S(0.958)YGNIR 147.3 0.0016532 51521600.0 205533.0 146081.0 223212.0 231748.0 250150.0 175816.0 155834.0 202653.0 134703.0 155516.0 True False 194110.2986737886 157284.9429755517 208850.78293485026 200183.52261240163 218723.92063062597 200033.05810125757 163080.58977921284 203242.68667898994 161647.36391628822 151025.84900090605 1.2852786457278853 1.0414438588894017 1.3828810386862802 1.3254917879071195 1.4482548654920244 1.3244955047401026 1.079819056526108 1.3457476850719152 1.070329119059072 1.0 17.204435971231142 -8.448997555577941 1.2339822866808825 0.9924933001365606 1.2850515355091765 0.37027242526023296 0.12345061119233514 0.5346205783885634 1.7698782588714115 0.12128463642151041 0.03792485275577655 3.556333202418653e-09 8.448997555577941 0.29255823537261594 SVSSNVASVS(ph)PIPAGSK ddPTM_A459_Selumetinib_30min_R1 2 SVSSNVASVSPIPAGSK 17 0 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVSSNVAS(0.001)VS(0.997)PIPAGS(0.001)K;SVSSNVAS(0.054)VS(0.946)PIPAGSK 248.23 2.0499999999999998e-30 42843000.0 6362.9 7644.5 8228.5 8558.8 6961.3 5842.6 7384.6 6349.1 3314.3 5584.0 True False 6511.143189951855 6749.47838616837 7111.114895915134 7064.166248573928 6331.651644117338 5783.828748656357 6827.57367662443 6180.7012432166675 5624.125033105465 6300.760792766054 1.0333899990977824 1.0712164146776517 1.1286121041254975 1.1211608377014322 1.0049027176824028 0.9179572021360991 1.083610995748833 0.9809452297114298 0.8926104669078314 1.0 12.621310323700522 -6.391587427547503 5.105270201333082 0.978854172150431 1.0896439443268857 0.5011339410339095 0.0535835800149983 0.20479342797814562 7.650529381438407 0.01742734443856862 0.01976806828006795 4.0589394477316315e-07 6.391587427547503 0.11078977217645469 SVSSNVASVS(ph)PIPAGSK ddPTM_A459_Selumetinib_30min_R2 2 SVSSNVASVSPIPAGSK 17 0 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVSSNVAS(0.003)VS(0.955)PIPAGS(0.041)K;SVS(0.005)SNVAS(0.004)VS(0.976)PIPAGS(0.015)K 234.62 5.6209e-17 122309000.0 194954.0 179910.0 212658.0 236640.0 240314.0 176810.0 204730.0 188193.0 160135.0 201678.0 True False 184119.23714269628 193708.51849817252 198975.81580452368 204409.22377323115 210123.60688558168 201163.97257862426 214250.3506647986 188740.61047297154 192166.47454574003 195855.032117626 0.9400791756635517 0.9890402937507149 1.015934151158411 1.0436761392501148 1.0728527350749217 1.0271064797447218 1.0939231346178782 0.9636750632969099 0.9811668991498227 1.0 17.579426670470582 -4.903892177128363 1.7852543102759462 1.0290696322769255 0.9239033296025637 0.3340372188916523 0.03720550732774364 0.8055607691611557 3.212513139528139 0.010934622255063106 0.13371620551823366 1.2476932422623752e-05 4.903892177128363 -0.10516630267436178 SVSSNVASVS(ph)PIPAGSKK ddPTM_A459_Selumetinib_30min_R1 1 SVSSNVASVSPIPAGSKK 18 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVSSNVAS(0.008)VS(0.992)PIPAGSKK 135.68 0.00018363 23043000.0 5011.3 4933.3 8479.5 8217.5 7205.3 5451.3 6259.3 5826.5 3448.6 4872.8 True False 5128.053539707641 4355.706942571053 7328.03047455944 6782.467886579455 6553.58188719904 5396.464871384381 5787.155961608659 5671.962292860703 5852.022324221554 5498.271345091403 0.9326665087720206 0.7921957046480841 1.3327880736736573 1.2335636895466284 1.191934969351734 0.9814839124304204 1.052540989410273 1.0315901011186657 1.0643385815154363 1.0 12.424762391687182 -10.359387892570348 14.824212042124827 0.9999963119537933 1.072217795046477 0.01825643244835684 0.14713293576880307 0.0 0.0 0.15343530702365377 0.037213528091623524 4.3713150427761486e-11 10.359387892570348 0.07222148309268372 SVSSNVASVS(ph)PIPAGSKK ddPTM_A459_Selumetinib_30min_R2 1 SVSSNVASVSPIPAGSKK 18 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVSS(0.001)NVAS(0.078)VS(0.921)PIPAGSKK 119.28 0.00050246 33395000.0 50574.0 57673.0 58826.0 65976.0 63776.0 36115.0 40354.0 40973.0 31962.0 56294.0 True False 47763.29954376274 62096.33365207664 55041.199204906035 56989.954985051874 55763.88871532601 41089.51343067142 42230.540959934 41092.22464655468 38355.29309289626 54668.64595062257 0.8736872610106928 1.1358674167302927 1.0068147518162414 1.042461432765793 1.02003420325597 0.7516102276940241 0.7724819268082325 0.7516598213109157 0.7015958128456165 1.0 15.738426022427097 -6.757113616957605 24.9666319561472 0.7785115540713117 1.0234299754727065 0.5647722998523135 0.09600472763376196 69.01123397703604 398306.19195455103 0.030155668093076453 0.029154643745865502 1.7493889663608905e-07 6.757113616957605 0.24491842140139486 SVSSNVASVSPIPAGS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 SVSSNVASVSPIPAGSK 17 0 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVSSNVAS(0.01)VS(0.016)PIPAGS(0.973)K;SVSSNVASVS(0.081)PIPAGS(0.919)K 171.87 6.4106e-07 44132000.0 11666.099999999999 12821.5 14451.3 15129.2 13756.400000000001 10522.5 13271.8 12550.9 7482.700000000001 11204.0 True False 11937.897431720961 11320.352819446365 12488.892835308792 12487.169230257128 12512.136048889675 10416.65320366558 12270.69744081252 12218.00936093116 12697.595385215054 12642.142536201789 0.9442938487314025 0.8954457511477685 0.9878778695577783 0.9877415315085333 0.9897164197492767 0.8239626450846175 0.9706185012290752 0.9664508469149048 1.0043863489795715 1.0 13.625953365565374 -7.95819582888377 2.316437631419257 1.0006495984104695 0.9414570971938118 0.19579476448164368 0.048282299492051435 0.5642953773131485 5.728576418698258 0.03944408052953411 0.014048709590980216 1.101042723478727e-08 7.95819582888377 -0.059192501216657756 SVSSNVASVSPIPAGS(ph)K ddPTM_A459_Selumetinib_30min_R2 2 SVSSNVASVSPIPAGSK 17 0 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 1 SVSSNVAS(0.001)VS(0.174)PIPAGS(0.825)K;SVSSNVASVS(0.381)PIPAGS(0.618)K 245.04 2.865e-23 12611300.0 88123.0 80686.0 85691.0 104097.0 105881.0 82508.0 89035.0 77518.0 71527.0 90278.0 True False 83225.4764443192 86874.35675361888 80177.73435330641 89918.80902265866 92579.28219185026 93872.72806694816 93175.30391950562 77743.5645462043 85834.39863136207 87671.43956958668 0.9492883526597207 0.9909082955648841 0.9145251263915616 1.0256339973896311 1.055979947932395 1.070733280162913 1.0627783047357218 0.8867604424870609 0.9790463011986188 1.0 16.41981931683705 -3.630147369178647 12.599140139446874 0.9948411539208728 0.7285490641284422 0.0 0.05963215846622949 0.0 0.0 0.014743556732384755 0.0 0.00023434334829304653 3.630147369178647 -0.2662920897924306 SVSSPTSSNT(ph)PTPTK ddPTM_A459_Selumetinib_30min_R1 2 SVSSPTSSNTPTPTK 15 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 SVSSPT(0.009)S(0.005)S(0.018)NT(0.965)PT(0.003)PTK;SVSSPT(0.001)S(0.076)S(0.076)NT(0.84)PT(0.006)PTK 246.75 1.7838e-27 15666900.0 8481.5 7984.4 7487.7 8042.8 8436.7 7128.9 6614.7 5510.5 4445.2 7415.1 True False 8679.102447873875 7049.582736153139 6470.91146699201 6638.2759620543075 7673.601974620365 7057.18973852331 6115.747853474479 5364.3436393733655 7543.179735437468 8366.900314190465 1.0373139540283403 0.8425560806786327 0.7733941153831112 0.793397281284161 0.9171379706300253 0.843465258759465 0.7309454665190671 0.6411387058449004 0.9015500904969613 1.0 13.030477531141868 -7.019712608609178 22.78356677703534 0.7883179833303163 0.8630674432742431 0.01896125653942904 0.1136598228629018 656.467909546075 758734.2938148987 0.04262567512363816 0.03358227186455727 9.556247549503456e-08 7.019712608609178 0.07474945994392679 SVSSPTSSNT(ph)PTPTK ddPTM_A459_Selumetinib_30min_R2 2 SVSSPTSSNTPTPTK 15 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 SVSSPT(0.161)S(0.034)S(0.237)NT(0.522)PT(0.037)PT(0.009)K;SVS(0.003)S(0.019)PT(0.029)S(0.019)S(0.149)NT(0.782)PTPTK 146.84 0.00078476 9922500.0 49687.0 35851.0 46048.0 47206.0 51603.0 51713.0 56396.0 41278.0 26866.0 35289.0 True False 46925.59545282043 38600.6564208659 43085.321813271585 40776.461365107876 45120.169803326775 58835.99634612518 59018.52574655395 41398.11214605922 32239.9506987595 34270.11487816676 1.3692862022682155 1.1263649555332567 1.25722723622152 1.1898548198648224 1.3166039846593134 1.716831021876999 1.7221572193840011 1.2079945542415924 0.9407599248901071 1.0 15.064663407528034 -8.002915636784936 24.88732837702888 1.0050456211742504 1.3797146487687568 0.4341653346659984 0.188255190785009 117.52880217550864 1003195.571768098 0.12209770124278307 0.05689750682091942 9.933089834093178e-09 8.002915636784936 0.3746690275945064 SVSSS(ph)PWLPQDGFDPSDYAEPMDAVVKPR ddPTM_A459_Selumetinib_30min_R1 1 SVSSSPWLPQDGFDPSDYAEPMDAVVKPR 29 1 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 S(0.341)VS(0.13)S(0.13)S(0.397)PWLPQDGFDPS(0.002)DYAEPMDAVVKPR 66.666 0.00031299 11447000.0 690.47 911.66 865.37 854.1 577.67 539.77 948.2 1144.4 622.89 678.8 True False 706.5566075792578 804.9224233807644 747.8575071371549 704.9474684426542 525.4198504959219 534.3404038719476 876.6765105998007 1114.0467944649088 1056.9988359143892 765.9305920719189 0.9224812468554775 1.0509077868314003 0.9764037562648145 0.9203803526579357 0.685988855823879 0.6976355421794856 1.1445900185659161 1.4545009769766484 1.3800190863967212 1.0 9.58106985214617 -7.487804323897378 5.826373157730856 1.312253591796824 0.8830728020881488 0.587851983147142 0.1535399387260214 0.1302204198485286 12.810059908201078 0.07122453242764902 0.04571515902338314 3.252338020053771e-08 7.487804323897378 -0.42918078970867535 SVSSS(ph)SYR ddPTM_A459_Selumetinib_30min_R1 1 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVS(0.021)S(0.131)S(0.845)S(0.003)YR 106.68 0.013623 45399000.0 1846.5 5449.6 4107.8 4580.0 3800.3 3885.2 4147.9 2941.7 1238.9 3033.2 True False 1889.519857336451 4811.558298549697 3549.983322530252 3780.1889772478157 3456.5635359974585 3846.1184154793514 3835.020563506552 2863.676560011729 2102.3228143240985 3422.5407658699837 0.5520810376253179 1.4058439702256214 1.0372362421307415 1.1044978674744639 1.0099407932454025 1.1237611700153693 1.1205185930142514 0.8367107233809103 0.6142579323784049 1.0 11.74085201018272 -7.843925740559832 5.412517492053291 0.78378686024464 1.066729849224147 0.1921849612723875 0.21631418456145304 0.2814524326656965 13.676813502728802 0.1131676773079059 0.05341013111188244 1.4324328081295986e-08 7.843925740559832 0.2829429889795071 SVSSS(ph)SYR ddPTM_A459_Selumetinib_30min_R2 1 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 S(0.128)VS(0.268)S(0.268)S(0.335)S(0.001)YR 84.615 0.036427 43792000.0 181550.0 199490.0 229520.0 217050.0 251910.0 166130.0 169060.0 186290.0 153420.0 215520.0 True False 171460.17780223297 214790.24153854922 214752.93308248097 187487.41556786574 220262.81369602663 189012.89952201134 176921.62498603473 186832.07305803036 184108.2869129634 209297.37761179137 0.8192179938358352 1.0262443036288114 1.0260660479024666 0.895794384560426 1.052391655401312 0.9030829802014814 0.8453121916997557 0.8926632296586627 0.87964927708961 1.0 17.6751947099188 -6.968539052469577 24.967435029893718 0.8924236904203218 0.9681361625307543 0.1304368176895906 0.07429452757611901 314.05450881929266 249233.13034629784 0.025096848976860583 0.022133189703173798 1.0751299186065412e-07 6.968539052469577 0.07571247211043253 SVSSS(ph)SYRR ddPTM_A459_Selumetinib_30min_R1 2 SVSSSSYRR 9 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVSS(0.003)S(0.852)S(0.145)YRR;SVSSS(0.5)S(0.5)YRR 112.85 0.004855399999999999 69049000.0 3154.9 4083.2 3984.7 4614.2 4255.3 4042.3 3692.7 4172.700000000001 2495.7 2884.8 True False 3228.4030316332337 3605.1370457718203 3443.5996263903544 3808.4165892613223 3870.4088663342327 4001.63813211474 3414.1566659901755 4062.026441160193 4235.020621283922 3255.092180331572 0.9918008009543928 1.1075376198423332 1.0579115538410284 1.1699873239452738 1.1890320310191593 1.229347099997372 1.048866353653432 1.2478990505105834 1.301044759000506 1.0 11.668482684035848 -5.7741693866576185 5.302345666203485 1.1787312575194988 1.0569015296572073 0.26513857412037245 0.08834342013654724 0.2252984914533492 18.391558648497 0.024299549822784743 0.03896807773940776 1.6820179003986273e-06 5.7741693866576185 -0.12182972786229151 SVSSS(ph)SYRR ddPTM_A459_Selumetinib_30min_R2 2 SVSSSSYRR 9 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVS(0.003)S(0.086)S(0.455)S(0.455)YRR;SVS(0.007)S(0.055)S(0.469)S(0.469)YRR 88.134 0.016222 266836950.0 8315.2 6970.200000000001 5746.900000000001 7987.7 8396.1 4778.6 8433.7 7364.6 7374.5 8727.599999999999 True False 7853.074472382968 7504.791927274547 5377.150710751614 6899.7614804489285 7341.306855913646 5436.80877418819 8825.883761059515 7386.029766724836 8849.606060745999 8475.611510971929 0.9265496020218639 0.8854572814668739 0.6344262834358009 0.8140724089957384 0.8661683993432342 0.6414650750745337 1.0413270770650764 0.8714450582313032 1.0441259665205187 1.0 13.049101746364743 -7.280537833313903 24.966985718372104 0.9785116191966156 0.79566096811772 0.47354946865979786 0.10022701118350817 799.2697777863566 1044863.3792692336 0.04198298020975739 0.028354839544978593 5.241579373023942e-08 7.280537833313903 -0.18285065107889553 SVSSSS(ph)YR ddPTM_A459_Selumetinib_30min_R2 1 SVSSSSYR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVS(0.045)S(0.045)S(0.076)S(0.834)YR 93.143 0.024476 45174000.0 458310.0 319270.0 425670.0 414440.0 428340.0 319530.0 468760.0 513440.0 515730.0 427560.0 True False 432838.96496029437 343756.98238514573 398282.8556344544 357992.5570511234 374528.0997918145 363542.35709545715 490558.26883031795 514934.02539543237 618890.4107001879 415215.2318657087 1.0424448135377788 0.8279007030655503 0.959220243064853 0.8621855114576032 0.9020095387852884 0.8755515915491175 1.1814553782771078 1.2401616941691949 1.4905291598270485 1.0 18.66349984331095 -7.37902482408906 3.3535932517243485 1.2670836171574855 0.9065816268379121 0.6096683215235776 0.12398664825331694 0.15453694743079763 3.2379973422944834 0.05400273564479875 0.03439556008745761 4.1780648432199033e-08 7.37902482408906 -0.3605019903195734 SVSSSS(ph)YRR ddPTM_A459_Selumetinib_30min_R1 1 SVSSSSYRR 9 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVSS(0.017)S(0.147)S(0.836)YRR 99.788 0.0094951 37128000.0 1373.0 1511.2 1506.1 1865.0 1809.1 1509.7 1307.1 1395.8 1235.5 1097.7 True False 1404.9882286070651 1334.26800146218 1301.5798924151152 1539.3127603858459 1645.4672244225462 1494.513788697925 1208.504394647753 1358.7788498026214 2096.5532626502727 1238.600487503456 1.1343352782292078 1.0772383952080895 1.0508472308440646 1.2427839129052103 1.328489081850095 1.2066148881551728 0.975701533174458 1.0970275431922354 1.6926791841299214 1.0 10.27449520366375 -5.76437484881201 24.880039999558036 1.218238402906971 1.086450102898933 0.09279523512484633 0.19046692353431 185.81426925120013 1574924.1400210864 0.05341446588955126 0.08332850931578673 1.7203830347590245e-06 5.76437484881201 -0.13178830000803798 SVSSSS(ph)YRR ddPTM_A459_Selumetinib_30min_R2 2 SVSSSSYRR 9 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 SVSSS(0.17)S(0.829)YRR;SVSS(0.002)S(0.181)S(0.817)YRR 77.288 0.027923000000000003 56211000.0 8575.4 9743.0 8084.9 8850.43 9119.7 6069.6 10569.1 11574.6 7823.599999999999 7400.2 True False 8098.813598046091 10490.256771317308 7564.726336173545 7644.986166156666 7974.001754847571 6905.63230565702 11060.584092274335 11608.280169721822 9388.538609648434 7186.536997971313 1.126942448126588 1.4597095616816003 1.0526246978633784 1.063792779236337 1.109574995174804 0.9609123709522973 1.5390700827667938 1.6152814871750778 1.3064064948526284 1.0 12.811081026203762 -7.268121224072463 24.98763966839348 1.4164629731847815 1.1366532987966496 0.24058052007623065 0.19711986440085974 666.4051730671972 2492099.3993841936 0.0809884055348436 0.056010026397582874 5.3936005060913156e-08 7.268121224072463 -0.279809674388132 SVSSSSYRR ddPTM_A459_Selumetinib_30min_R2 1 SVSSSSYRR 9 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 0 85.86200000000002 0.046826 540250.0 1340.9 1855.3 640.68 3199.2 2327.8 2067.3 1222.8 985.99 1137.6 2243.8 False True 1266.3781460479986 1997.5955442702448 599.459346319641 2763.463441072176 2035.360953203964 2352.051809919063 1279.6626229322333 988.859067660569 1365.1517871997617 2179.0156639074667 0.581169822238495 0.9167421681990598 0.2751055700282003 1.2682164184706515 0.9340735759347882 1.0794102350330532 0.5872663717513207 0.4538099858756048 0.6264992995744402 1.0 11.089460852001817 -10.748077114038795 4.539167526001084 1.0000697351262655 0.755338372548922 0.06479490242986274 0.28684302692063723 0.00022186520640451944 3.787077003443413e-05 0.2852950669955063 0.06917322317200345 1.7861703913558716e-11 10.748077114038795 -0.24473136257734351 SVSSVLSS(ph)LTPAK ddPTM_A459_Selumetinib_30min_R1 1 SVSSVLSSLTPAK 13 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 SVSSVLS(0.022)S(0.489)LT(0.489)PAK 225.33 1.5136e-09 73994000.0 3312.1 4362.3 4115.7 4927.5 4144.6 3418.7 4304.9 3124.1 2051.1 2998.6 True False 3389.26548577528 3851.559888021749 3556.810545921844 4067.0046256306973 3769.7216617885642 3384.3109819312435 3980.177927105127 3041.2387194930284 3480.566893583144 3383.499518837444 1.0017041429755595 1.1383361713452018 1.0512224181264105 1.2020112912645255 1.1141487211098597 1.0002398295283572 1.1763494881396344 0.8988441412688556 1.0286884553124014 1.0 11.724300468046014 -7.762542276027646 24.999998633748778 0.9728247318950782 1.0983844065370996 0.38776724114295025 0.070141176828948 28.97457828246848 656721.6482447003 0.03430513000340065 0.017933470950332733 1.7276577949407047e-08 7.762542276027646 0.12555967464202133 SVSSVLSSLT(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 SVSSVLSSLTPAK 13 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 SVSSVLS(0.004)S(0.08)LT(0.916)PAK 209.39 1.9831e-05 79847000.0 4870.0 6620.8 6807.0 7260.9 5542.1 5845.1 5639.5 4659.0 3160.8 4403.8 True False 4983.46152462958 5845.633658073584 5882.646788174556 5992.920118973505 5040.818033537227 5786.303600926176 5214.107974612499 4535.428185435172 5363.646744301889 4969.070626644547 1.0028960944744612 1.176403818196674 1.183852520958616 1.2060444636948802 1.0144387979731995 1.1644639482279768 1.049312510603903 0.9127316808732502 1.0794064217042105 1.0 12.27876033208155 -7.486494937214587 5.741233807879191 0.9936703730883722 1.1273323618855127 0.37499073726569077 0.07443741084734776 0.1913542774016151 17.744246547327386 0.03234736555371689 0.020763898508340255 3.2621585323152456e-08 7.486494937214587 0.13366198879714042 SVSSVLSSLT(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 SVSSVLSSLTPAK 13 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 SVSSVLS(0.005)S(0.182)LT(0.813)PAK;SVSSVLS(0.002)S(0.034)LT(0.964)PAK 223.39 1.3262e-08 67580000.0 146175.0 157125.0 163564.0 158744.0 170248.0 150763.0 152788.0 144474.0 110044.0 170633.0 True False 138051.178684888 169175.98226349495 153040.47031501803 137122.7933513258 148859.9242035693 171529.23475974824 159892.9447436785 144894.39542104185 132055.8748862609 165706.3819322232 0.8331071928258825 1.0209382420327715 0.9235641290968157 0.82750460032017 0.8983354923798628 1.0351395809843142 0.9649172402368759 0.8744044359154869 0.7969269097932152 1.0 17.338269641297124 -11.483877230346994 2.8669894586474314 1.0666058044070912 0.9138034468620134 0.11117193896779021 0.07636704381350896 122082995.96285006 76765440.94178681 54141032.825896025 0.019801438674384896 3.2818805468585757e-12 11.483877230346994 -0.15280235754507776 SVST(ph)MNLSK ddPTM_A459_Selumetinib_30min_R1 1 SVSTMNLSK 9 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40 Q14244-5 MAP7 Ensconsin 1 S(0.001)VS(0.273)T(0.726)MNLSK 123.01 0.013479 30329000.0 3483.7 3307.6 4424.4 4205.5 3794.3 3062.4 3518.8 3281.7 2593.4 3336.8 True False 3564.8634318998065 2920.344654338477 3823.5907814895695 3471.0883720121587 3451.1062349380727 3031.5950364367272 3253.3740829978665 3194.6586555360814 4400.810385558251 3765.110783184412 0.9468150174547474 0.7756331280825001 1.0155320790470066 0.921908695891392 0.9166015115282308 0.8051808329189984 0.8640845569612338 0.8484899487696189 1.1688395478860742 1.0 11.878476599492732 -8.253025323483739 24.852401443309624 1.0844197784865324 0.8860559332120727 0.5205672750522541 0.07586535746188494 389.59381950988774 1150743.5986353755 0.05197014929180066 0.01889976799542477 5.584376315817047e-09 8.253025323483739 -0.19836384527445972 SVST(ph)PSEAGSQDSGDGAVGSR ddPTM_A459_Selumetinib_30min_R1 2 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 S(0.001)VS(0.094)T(0.848)PS(0.058)EAGSQDSGDGAVGSR;S(0.001)VS(0.088)T(0.823)PS(0.088)EAGSQDSGDGAVGSR 254.8 3.622999999999999e-39 36509000.0 3185.6 3764.1 3653.0 4633.799999999999 4099.7 2961.2 3908.7000000000003 3445.6000000000004 1846.8000000000002 2884.3 True False 3259.818281901434 3323.3974221173844 3156.9426644926734 3824.5938171988905 3728.882858860822 2931.4130165544775 3613.8636120875744 3354.211495113851 3133.88471506477 3254.5280004611604 1.0016255141880863 1.0211611089677106 0.9700155180859837 1.1751608272096454 1.1457522744718887 0.9007183272471774 1.110410975593234 1.0306291710006998 0.9629306352935677 1.0 11.668232611226484 -9.726406110338482 11.151791035073222 1.0000003690674535 1.0385018017279508 0.01538830002885172 0.08152145671021754 0.0 0.0 0.07980000300645923 0.019354343607072843 1.8775602822596164e-10 9.726406110338482 0.038501432660497326 SVST(ph)PSEAGSQDSGDGAVGSR ddPTM_A459_Selumetinib_30min_R2 6 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 SVS(0.12)T(0.877)PS(0.004)EAGSQDSGDGAVGSR;SVS(0.031)T(0.968)PS(0.001)EAGSQDSGDGAVGSR;SVS(0.029)T(0.789)PS(0.18)EAGS(0.001)QDS(0.001)GDGAVGSR;SVS(0.032)T(0.967)PSEAGSQDSGDGAVGSR;S(0.001)VS(0.018)T(0.557)PS(0.419)EAGS(0.001)QDS(0.005)GDGAVGSR;SVS(0.006)T(0.972)PS(0.022)EAGSQDSGDGAVGSR 276.88 2.3895999999999997e-72 62735500.0 94412.2 92251.2 106113.0 122269.0 114806.90000000001 76180.20000000001 86165.59999999999 87660.8 79214.3 95310.0 True False 89165.14788598167 99326.57040563972 99285.80510709887 105615.7512742103 100383.83083529175 86673.33105499743 90172.47113389736 87915.8784149734 95059.37343247018 92558.15265488061 0.9633419134719514 1.0731261110622674 1.0726856820198594 1.141074537950398 1.0845487723765463 0.9364202781593343 0.974225052547465 0.9498447829094347 1.0270232357263633 1.0 16.498072449891147 -6.752359405065276 24.99365232702091 0.974163116258559 1.071734313617946 0.47184369205959653 0.0471186638458833 167.08825320237096 459928.5372816744 0.016130246194143237 0.015908759350499527 1.7686446915963908e-07 6.752359405065276 0.09757119735938702 SVST(ph)SPSILTAFLK ddPTM_A459_Selumetinib_30min_R1 1 SVSTSPSILTAFLK 14 0 Q6ZVF9 Q6ZVF9 GPRIN3 G protein-regulated inducer of neurite outgrowth 3 1 SVS(0.001)T(0.499)S(0.499)PS(0.002)ILTAFLK 295.86 4.8873e-67 11077000.0 2867.2 3080.3 3439.0 3397.5 3687.5 2816.8 3515.7 3519.2 1653.9 2710.3 True False 2934.000181399985 2719.6570440073806 2972.0026890748177 2804.190403973679 3353.9662760810006 2788.4655494497683 3250.5079184936903 3425.8593840273547 2806.5475039233406 3058.1934055576353 0.9593900032836529 0.8893018469874944 0.9718164598987808 0.91694344735609 1.0967149003676024 0.9118015702938564 1.062885006745016 1.1202232591966101 0.9177141965001363 1.0 11.578463932830939 -6.2330380215903665 24.911370492343163 1.0211463427243528 0.9338195301452934 0.27331863335230033 0.0668841249908703 906.2521083429394 794890.5757277135 0.019150893824098066 0.024718567522833836 5.847388892141152e-07 6.2330380215903665 -0.08732681257905939 SVST(ph)TNIAGHFNDESPLGLR ddPTM_A459_Selumetinib_30min_R2 1 SVSTTNIAGHFNDESPLGLR 20 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 S(0.001)VS(0.078)T(0.757)T(0.165)NIAGHFNDESPLGLR 124.77 0.00054402 3943200.0 8127.9 5899.5 7659.4 10144.0 9573.9 8227.1 7464.5 8428.0 9517.4 7404.9 True False 7676.183856561656 6351.972680117669 7166.6025429241745 8762.369700623954 8371.141090248051 9360.308346822001 7811.614040626147 8452.524084669485 11421.145938374668 7191.101296759245 1.0674559486487862 0.8833101381815135 0.9965931847120397 1.2185017758785877 1.1640972286151225 1.3016515774906876 1.0862889727539429 1.1754144095395673 1.5882332158944474 1.0 12.811997016898856 -5.739896303395752 4.816579889488341 1.2231443597010194 0.9677565629905445 0.3374335215093863 0.15197269573421976 0.20431419222861333 11.83374075833775 0.04124138644955243 0.0696764153740195 1.8201354009240895e-06 5.739896303395752 -0.25538779671047496 SVSTPS(ph)EAGSQDSGDGAVGSR ddPTM_A459_Selumetinib_30min_R1 1 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 SVST(0.164)PS(0.768)EAGS(0.064)QDS(0.003)GDGAVGSR 346.18 1.1316999999999991e-175 9155700.0 959.45 1437.5 1048.9 1469.5 1037.9 911.68 934.25 885.73 668.19 710.44 True False 981.8033182352868 1269.1968317243798 906.4651411952825 1212.879410931367 944.0221282561276 902.5093269392091 863.7787703310099 862.2375631434844 1133.8696273332948 801.6318942716179 1.2247558078104877 1.583266385474349 1.1307747953553153 1.5130129172734805 1.1776254600172678 1.1258400936744801 1.077525453395115 1.075602866234426 1.4144517395525489 1.0 9.646796099495617 -6.4267399912070875 7.325857052061863 1.1408656362220744 1.3616501048080614 0.3174251951858691 0.15726025214557462 0.3228995075298544 21.55810547589553 0.04628930249661847 0.0524183375428719 3.743346324871044e-07 6.4267399912070875 0.220784468585987 SVSTPSEAGSQDS(ph)GDGAVGSR ddPTM_A459_Selumetinib_30min_R1 1 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 SVS(0.063)T(0.113)PS(0.238)EAGS(0.025)QDS(0.561)GDGAVGSR 267.93 8.213399999999997e-60 12083000.0 1901.8 1971.6 2048.6 2293.4 1982.5 1806.2 1774.4 1747.9 1143.8 1180.3 True False 1946.1082397413834 1740.7641554280267 1770.4113721543106 1892.9007424498109 1803.1832250388036 1788.0312678983857 1640.5555794223644 1701.540014020635 1940.9450601532837 1331.803002095589 1.4612583367654124 1.3070733079058527 1.3293342704353215 1.4213068595515523 1.3539414028962984 1.3425643770774827 1.2318305161055758 1.2776213984675404 1.4573815024438384 1.0 10.379164981997326 -12.7930149267857 0.35545257396406055 1.5645924402547696e-27 1.3595238469217674 0.677327870970566 0.0725104665694706 70.09412763496488 1.8196534492333312 52.44652355719977 0.055168543629047495 1.6105902779262639e-13 12.7930149267857 1.3595238469217674 SVSTPSEAGSQDS(ph)GDGAVGSR ddPTM_A459_Selumetinib_30min_R2 1 SVSTPSEAGSQDSGDGAVGSR 21 0 E7EQL5;Q13409-2;E7EV09;Q13409-3;Q13409-6;E7EQU2;E9PGG1;E7ETL8;E7ESD3;E7EMU4;Q13409;Q13409-7;Q13409-5;E7ET01;E7ERR6;E7EUM4;E7ERH4 E7EQL5 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 SVST(0.001)PS(0.013)EAGS(0.004)QDS(0.978)GDGAVGS(0.004)R 152.64 1.0574e-06 12826000.0 11424.0 11492.0 12596.0 11968.0 16553.0 7946.8 10681.0 10329.0 6304.1 9688.5 True False 10789.099813895386 12373.399447395925 11785.587073487855 10337.937754048455 14473.46415430243 9041.39956613206 11177.687663999985 10359.055679942003 7565.096151271115 9408.767831253894 1.1467069872907616 1.3150924402974602 1.2526174824230099 1.0987557498983087 1.5382953872264453 0.9609546891037618 1.1880075972190665 1.1010002442117297 0.8040474892091077 1.0 13.199790085178678 -7.733988517688609 1.149969069613827 0.9168212923229918 1.243597146605048 0.39143808959794735 0.15047499670444142 0.4981671742126727 1.1960766395002589 0.12281315266466623 0.049107465421103697 1.8450642001852298e-08 7.733988517688609 0.32677585428205613 SVSTS(ph)PSILTAFLK ddPTM_A459_Selumetinib_30min_R1 1 SVSTSPSILTAFLK 14 0 Q6ZVF9 Q6ZVF9 GPRIN3 G protein-regulated inducer of neurite outgrowth 3 1 SVST(0.049)S(0.948)PS(0.003)ILTAFLK 308.74 7.536599999999995e-94 4129300.0 1805.9 1627.1 2466.8 2228.8 2228.9 1670.5 2083.1 2244.1 1072.7 1940.5 True False 1847.973956330298 1436.5983755817313 2131.8221091624764 1839.581919757625 2027.296388544256 1653.696286692643 1925.9700898865685 2184.5791781358803 1820.2935530918242 2189.582077070653 0.8439847839833536 0.6561061997290797 0.9736205513768859 0.8401520724076814 0.9258828019164679 0.7552565870949454 0.8796062545703883 0.997715135236462 0.8313429179723264 1.0 11.096439815276318 -1.5228787581051058 0.06286143540778273 1.1709035728496215 0.2162548126984175 0.2429910554768948 0.09089588097316718 436.7481007244398 2.0524830636149223 6.060534708022952 37.758826131033 0.029999999114096412 1.5228787581051058 -0.954648760151204 SVSTTGS(ph)LQR ddPTM_A459_Selumetinib_30min_R2 1 SVSTTGSLQR 10 0 H0Y5T1;Q7Z460-2;Q7Z460-3;F8WA11;Q7Z460-5;Q7Z460;Q7Z460-4 H0Y5T1;Q7Z460;Q7Z460-4 CLASP1 CLIP-associating protein 1 1 S(0.026)VS(0.033)T(0.004)T(0.003)GS(0.934)LQR 86.911 0.034395 10855000.0 36755.0 37243.0 40727.0 44556.0 43344.0 26194.0 25150.0 27588.0 26516.0 35486.0 True False 34712.30424192272 40099.418344880476 38106.669160204816 38487.39593661285 37898.73921972357 29801.98573454261 26319.524833779567 27668.276512560733 31819.9409189424 34461.426976299284 1.0072799442053277 1.1636029573719828 1.1057774591404046 1.1168253700893584 1.0997437583123961 0.8647925622766235 0.7637386824370541 0.8028766925870332 0.92334948697355 1.0 15.072694821362072 -6.767660917241915 6.1437682594625596 0.8506970924370773 1.1044929789687177 0.716209647338911 0.07109910095876681 0.07450006833809115 10.776242415814679 0.02394607291700977 0.02225029762226977 1.7074149618147343e-07 6.767660917241915 0.2537958865316404 SVT(ph)PASTLTK ddPTM_A459_Selumetinib_30min_R1 1 SVTPASTLTK 10 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 S(0.073)VT(0.611)PAS(0.249)T(0.066)LTK 101.35 0.038475 6596700.0 4220.8 4496.7 5208.3 5310.5 4512.3 4195.6 4177.7 4012.3 2575.8 3682.4 True False 4319.136427752878 3970.224273540886 4501.041467144046 4383.120865431117 4104.163261711271 4153.396073300004 3862.572725514432 3905.880770212821 4370.944471011389 4155.071909613487 1.0394853619163122 0.9555127708752948 1.0832643971167135 1.0548844787234604 0.9877478298788451 0.9995966769408717 0.9296043027745664 0.9400272378381421 1.0519539892675367 1.0 12.020657729827393 -6.404596516715378 5.179528439740338 0.9786915380006336 1.0311187006560456 0.2207829444990359 0.04387830489035261 0.35273266051168 13.571685900746834 0.014213889081716613 0.01609723733125764 3.939158748598077e-07 6.404596516715378 0.05242716265541203 SVT(ph)PDSLGHT(ph)PPAR ddPTM_A459_Selumetinib_30min_R2 2 SVTPDSLGHTPPAR 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 2 S(0.175)VT(0.825)PDSLGHT(1)PPAR;S(0.37)VT(0.63)PDSLGHT(1)PPAR 117.3 0.0099327 23380000.0 67414.0 55979.0 91190.0 91332.0 110679.0 79374.0 78457.0 96627.0 97984.0 70195.0 True False 63667.39975962394 60272.409299145176 85322.93468016507 78892.42404351197 96774.51453718584 90307.04801456767 82105.40595959607 96908.168572539 117583.53790170638 68168.28796148703 0.9339738706008583 0.8841707940970619 1.2516514237290202 1.1573185480040769 1.4196412647455725 1.3247662617783265 1.204451636015607 1.4216019130081292 1.724900850790582 1.0 16.056813129931797 -5.38888164544377 1.0466698496911078 1.3633386923522584 0.827080658127449 0.4357668811733565 0.18292817936763003 0.7456447653427287 1.237317928010238 0.06354384376872593 0.3579394606837602 4.084306772824506e-06 5.38888164544377 -0.5362580342248093 SVT(ph)PDSLGHTPPAR ddPTM_A459_Selumetinib_30min_R2 2 SVTPDSLGHTPPAR 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 S(0.051)VT(0.949)PDSLGHTPPAR;S(0.046)VT(0.942)PDS(0.012)LGHTPPAR 142.74 0.00073706 21139700.0 54298.0 49617.0 69766.0 70972.0 87113.0 48008.0 59606.0 63451.0 60632.0 65359.0 True False 51280.33453211589 53422.46435619937 65277.33151547744 61305.4911664711 76169.0861398989 54620.666226766516 62377.79710704832 63635.63190512146 72760.09419962713 63471.91584692407 0.8079216429481859 0.8416708971734669 1.0284443228861644 0.9658679803256962 1.2000439111306602 0.8605485669992345 0.982762159842245 1.002579346408768 1.1463352449468118 1.0 15.953830769375779 -5.219990501536592 4.330408523604471 1.0209561805844922 0.816649933982579 0.44414502351475693 0.08897915347461754 0.19170811682493108 8.164454727206243 0.022911143859390855 0.0636536828993387 6.025727648113822e-06 5.219990501536592 -0.2043062466019132 SVTEQGAELSNEER ddPTM_A459_Selumetinib_30min_R1 4 SVTEQGAELSNEER 14 0 E7EX29;P63104;E7ESK7;E5RGE1;E5RIR4;E9PD24;E7EVZ2 E7EX29 YWHAZ 14-3-3 protein zeta/delta 0 ;;; 207.34 9.5029e-05 414277000.0 4640.07 5096.88 5099.52 5649.860000000001 5363.48 4728.96 4850.67 4675.6 2621.15 3869.58 False True 4748.174602995473 4500.134920124773 4407.033193658277 4663.218012007278 4878.354180999304 4681.390955952135 4484.780056603176 4551.587899510774 4447.900108778441 4366.278285901084 1.0874649511753636 1.0306569177360771 1.0093340151700345 1.068007512728867 1.1172797200654243 1.0721696258043296 1.027140223994595 1.0424410908961217 1.0186936831628248 1.0 12.09218836847107 -8.08415940450794 1.2003523168295567 1.0032984544710786 1.0607730784384342 0.34054257543252964 0.029010023424433387 0.6264606899146846 1.6678544537896953 0.029855381281224752 0.010101876058545373 8.238356768525065e-09 8.08415940450794 0.05747462396735559 SVTEQGAELSNEER ddPTM_A459_Selumetinib_30min_R2 1 SVTEQGAELSNEER 14 0 E7EX29;P63104;E7ESK7;E5RGE1;E5RIR4;E9PD24;E7EVZ2 E7EX29 YWHAZ 14-3-3 protein zeta/delta 0 168.83 0.002617 17760000.0 15590.0 18338.0 17888.0 20715.0 22765.0 13153.0 13403.0 19307.0 16906.0 20173.0 False True 14723.570211714738 19744.465634036413 16737.105554981805 17893.581264631823 19905.057178317806 14964.70635895393 14026.266057540653 19363.18017355408 20287.672393107583 19590.55307425142 0.7515648055422419 1.007856468329487 0.8543457395789399 0.9133780550662457 1.0160538654970261 0.7638736028653826 0.7159709072213938 0.9883937477499711 1.035584463399985 1.0 14.257870507436541 -7.974382438817896 24.927602979388784 1.0158579854723453 0.868892916413712 0.3323787403809376 0.09590539815936679 251.43120318578434 244659.2674000725 0.054062403279971326 0.025969274645829044 1.0607610418247836e-08 7.974382438817896 -0.14696506905863327 SVTLLEVCGS(ph)WPEGFGLR ddPTM_A459_Selumetinib_30min_R1 1 SVTLLEVCGSWPEGFGLR 18 0 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6;K7EIE2;Q9H6U6-8;Q9H6U6-3;Q9H6U6-7 K7ESE9;Q9H6U6-8 BCAS3 Breast carcinoma-amplified sequence 3 1 SVTLLEVCGS(1)WPEGFGLR 189.04 2.1441e-10 30218000.0 858.5 973.21 1146.3 1403.8 1236.0 1099.8 1203.7 1101.8 786.36 849.25 True False 878.5013796497934 859.2661207669462 990.6387561751857 1158.6526825896246 1124.2040182335238 1088.7370105385028 1112.90393989557 1072.5766848492112 1334.3954865379753 958.2595098955168 0.9167677133155508 0.8966945925333272 1.0337896425188615 1.209122028662108 1.1731728270101913 1.1361609243588018 1.1613805325207935 1.119296676707293 1.3925199518066564 1.0 9.904272600370069 -5.521205445133124 3.07473620794009 1.1733487906427182 0.9086963731944523 0.569585745932982 0.09217975516140724 0.1686982479985869 3.245542429735292 0.024472854857557246 0.052312251676708145 3.011581043993263e-06 5.521205445133124 -0.26465241744826595 SVTMT(ph)DGLTADK ddPTM_A459_Selumetinib_30min_R2 1 SVTMTDGLTADK 12 0 Q8N5H7-3;Q8N5H7-6;Q8N5H7-5;Q8N5H7-2;Q8N5H7-4;Q8N5H7;H0Y5X5;Q5JU32 Q8N5H7-3 SH2D3C SH2 domain-containing protein 3C 1 SVT(0.041)MT(0.955)DGLT(0.003)ADK 120.31 0.012219 0.0 12605.0 12222.0 14541.0 15791.0 11744.0 9577.6 11873.0 9508.2 7512.1 12440.0 True False 11904.464561812967 13159.388100075963 13605.44789104373 13640.238559005604 10268.613727307908 10896.827463203606 12425.11802590317 9535.867287832752 9014.729905611222 12080.82487699835 0.9854016330026297 1.0892789386535333 1.12620189677182 1.1290817223065908 0.8499927638930637 0.9019936613724904 1.0284991424352445 0.7893390877628609 0.7462015216175419 1.0 13.560431344587098 -6.2630828515318955 24.998800794479806 0.8833955168021893 1.086098104831107 0.544648035318803 0.08797040315413078 118.8552621178511 1807900.028084051 0.02799120982115231 0.03341484804704097 5.456537553199085e-07 6.2630828515318955 0.2027025880289176 SVTS(ph)SPVEK ddPTM_A459_Selumetinib_30min_R2 2 SVTSSPVEK 9 0 Q9Y4F3-3;Q9Y4F3-4;Q9Y4F3-5;Q9Y4F3;G8JLP4;F8VVB8 Q9Y4F3-3;F8VVB8 KIAA0430 Meiosis arrest female protein 1 1 SVT(0.02)S(0.912)S(0.068)PVEK;SVT(0.005)S(0.979)S(0.016)PVEK 192.44 0.00068248 26458000.0 253410.0 205810.0 242950.0 227410.0 240960.0 156321.0 203731.0 226630.0 172008.0 178569.0 True False 239326.48668060525 221594.96521654696 227318.86150395995 196436.36569586917 210688.45059026833 177852.79880924773 213204.89518531796 227289.4557793838 206414.40630507751 173413.24899201913 1.3800934361804131 1.2778433395636644 1.3108506000854738 1.13276446198704 1.214950136825847 1.0256009840253493 1.2294613959694056 1.3106810298551306 1.1903035523806902 1.0 17.403854600937088 -5.749856864894283 23.729685844842166 1.1704990985707981 1.318420689516895 0.40492981437536024 0.09082527488365304 134.69650028625756 275954.3836203152 0.02496097615311524 0.04270450866720697 1.7788655933116944e-06 5.749856864894283 0.14792159094609691 SVTVVEDDEDEDGDDLLHHHHVSGSR ddPTM_A459_Selumetinib_30min_R1 4 SVTVVEDDEDEDGDDLLHHHHVSGSR 26 0 P02545-2;Q5TCI8;Q3BDU5 P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;; 117.6 1.9553e-09 65239000.0 11204.7 13117.199999999999 12804.2 12858.6 15997.1 11203.699999999999 13051.5 10851.6 5028.49 8790.1 False True 11465.74770944908 11581.432125979161 11065.459968436111 10613.086895816312 14550.16512951739 11091.000950145686 12067.014847177072 10563.78031703548 8532.980263621423 9918.394957824654 1.1560083822235487 1.1676720049187528 1.115650265540851 1.0700407617306682 1.466987873681993 1.1182253779272986 1.2166297973098323 1.0650695361452287 0.8603186604189146 1.0 13.27589096034114 -7.998729087530536 3.8552014625009985 0.9332301967925531 1.1866330507943066 0.48082972403103275 0.1070043540517315 0.18919792712990927 6.205131297304073 0.07286457853444595 0.028550693423687584 1.0029306701485072e-08 7.998729087530536 0.25340285400175344 SVTVVEDDEDEDGDDLLHHHHVSGSR ddPTM_A459_Selumetinib_30min_R2 5 SVTVVEDDEDEDGDDLLHHHHVSGSR 26 0 P02545-2;Q5TCI8;Q3BDU5 P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;;; 103.28 1.5014000000000002e-07 50223200.0 81439.6 67436.8 109310.2 185483.0 177160.0 107945.1 76001.3 90226.7 110694.3 148920.0 False True 76913.51306054932 72608.98571651148 102277.30073994711 160219.89542397828 154903.57696950508 122813.55769694512 79535.51104371894 90489.24475916574 132836.25305716097 144620.29265937262 0.5318307109342215 0.50206637243868 0.7072126522440603 1.107865932766073 1.0711054038201466 0.8492138650708626 0.5499609327375011 0.6257022655340427 0.9185173851779788 1.0 17.14191047530801 -5.477561913965086 4.970805088350356 0.8565984442191652 0.529419316850483 0.41671873119494096 0.16820624513706078 0.23388650174338343 13.29124438388258 0.051416012489618815 0.10648795871585955 3.3299528639304624e-06 5.477561913965086 -0.32717912736868215 SVVASELSALQAAEHTS(ph)PEESR ddPTM_A459_Selumetinib_30min_R1 1 SVVASELSALQAAEHTSPEESR 22 0 A0A3B3IU36;Q8N7W2-2;Q8N7W2-3;Q8N7W2 A0A3B3IU36 BEND7 BEN domain-containing protein 7 1 SVVASELSALQAAEHT(0.054)S(0.891)PEES(0.054)R 136.26 1.0463e-05 4412500.0 1132.6 1524.6 1299.7 1521.6 1576.7 1190.5 1085.5 1477.9 755.78 1259.8 True False 1158.9873763440369 1346.0991232326892 1123.2078787410696 1255.881123969491 1434.0877633889943 1178.524650887514 1003.6198610589363 1438.7012911042366 1282.503460012807 1421.5076014911651 0.8153226723010528 0.9469517586966315 0.7901525658834477 0.8834853381382333 1.0088498731098114 0.8290667244067065 0.7060249695507337 1.0120953905522807 0.9022135785045803 1.0 10.473206098488843 SVVS(ph)DLEADDVK ddPTM_A459_Selumetinib_30min_R1 4 SVVSDLEADDVK 12 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 S(0.019)VVS(0.981)DLEADDVK;SVVS(1)DLEADDVK;S(0.001)VVS(0.999)DLEADDVK;S(0.066)VVS(0.934)DLEADDVK 225.72 2.7247e-09 492372000.0 16726.5 25410.800000000003 16283.499999999998 17139.8 14443.4 17686.3 19908.9 18883.1 9050.6 16784.2 True False 17116.194905896646 22435.691722839576 14072.290138862974 14146.655683893465 13136.997020189383 17508.391879875555 18407.15564425265 18382.25884704677 15358.207170329873 18938.6155619527 0.9037722345598871 1.184653210233193 0.7430474573407532 0.7469741194976158 0.6936619510130058 0.9244810858851564 0.9719377630343928 0.970623158113857 0.810946667146262 1.0 14.209043251279352 -9.45917765779987 15.819291179985896 0.9999870964262914 0.8848726966422973 0.061099390841141354 0.13707109984176366 0.0 0.0 0.14227985017520722 0.034507932392319696 3.4739402313489396e-10 9.45917765779987 -0.11511439978399407 SVVS(ph)DLEADDVK ddPTM_A459_Selumetinib_30min_R2 5 SVVSDLEADDVK 12 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 S(0.001)VVS(0.999)DLEADDVK;SVVS(1)DLEADDVK;SVVS(1)DLEADDVK;S(0.049)VVS(0.951)DLEADDVK;SVVS(1)DLEADDVK 162.94 0.00043685 128627000.0 420364.0 333037.9 374050.5 345470.2 360586.8 329315.9 396235.5 445900.4 308742.8 343144.6 True False 397001.85173042055 358580.8360443701 349984.49806539196 298416.56279066374 315286.66249710764 374676.17599290196 414661.23587574845 447197.8963412153 370499.98699460184 333237.12380125845 1.1913494126998623 1.0760530878253125 1.0502566282924757 0.8955081576344369 0.9461330685507404 1.1243530484207325 1.244342860560311 1.3419810231225098 1.1118208642791156 1.0 18.346189605454107 -6.985953719742812 6.14017008977235 1.2009980251306835 1.027837552340788 0.257919615549685 0.11131398515095256 0.18733460568004234 27.132759171284683 0.04171154266462378 0.035585038979967454 1.0328714670498804e-07 6.985953719742812 -0.17316047278989544 SVVS(ph)DLEADDVKGSVPLSSSPPAT(ph)HFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 1 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 38 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 2 S(0.123)VVS(0.657)DLEADDVKGS(0.192)VPLS(0.109)S(0.109)S(0.109)PPAT(0.61)HFPDET(0.076)EIT(0.015)NPVPK 44.289 0.021578 6256500.0 18239.0 23571.0 21228.0 21111.0 21436.0 13657.0 9625.0 12353.0 9969.4 25322.0 True False 17225.349396501933 25378.81990728936 19862.21359129883 18235.645381493723 18743.01803972857 15538.127784097449 10072.581571575683 12388.945184850756 11963.558568309867 24590.88806554279 0.7004769144811168 1.032041618002834 0.8077062340473232 0.7415610746911515 0.7621936218721452 0.6318652560526987 0.4096062551595919 0.5038022682153711 0.4865037218836122 1.0 14.585836216338661 -6.587409898914544 1.619702415683211 0.556843171100088 0.8448446613853089 0.2465101612171744 0.17140595992759006 0.41627439461245497 2.240268854778092 0.06664220454781215 0.0695525549280374 2.5857712420247997e-07 6.587409898914544 0.28800149028522093 SVVS(ph)DLEADDVKGSVPLSSSPPATHFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R1 1 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 38 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 S(0.147)VVS(0.564)DLEADDVKGS(0.057)VPLS(0.057)S(0.057)S(0.057)PPAT(0.057)HFPDET(0.002)EITNPVPK 54.632 0.00014839 33790000.0 3077.7 3635.6 5164.2 6604.0 4766.1 4088.1 3728.3 3603.8 1117.6 2580.8 True False 3149.4044218382865 3209.9422618554136 4462.930004920085 5450.735372433311 4335.007096523299 4046.9774256978108 3447.071329328451 3508.2155172078274 1896.4855737255718 2912.070819120815 1.0814999419516607 1.1022885297908136 1.5325623180646033 1.8717729447524032 1.4886338162037156 1.3897249335851096 1.1837182346990993 1.204715041328217 0.6512498120832586 1.0 11.50782972575915 -7.83004500170199 1.6094802054377257 0.8480061774336933 1.4223318260563598 0.4586013496728225 0.23506011858529172 0.38834568116996776 1.8729672867748839 0.2100064858065624 0.07814140741685387 1.4789551305304027e-08 7.83004500170199 0.5743256486226664 SVVS(ph)FDK ddPTM_A459_Selumetinib_30min_R1 2 SVVSFDK 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 S(0.032)VVS(0.968)FDK;S(0.002)VVS(0.998)FDK 93.111 0.026139 101941000.0 11905.8 16202.7 9982.400000000001 9056.5 9287.0 9852.2 12759.8 12608.7 5836.200000000001 11686.099999999999 True False 12183.181975345964 14305.68035156913 8626.84490939822 7474.9522865600065 8446.992489753018 9753.095813081867 11797.318013026086 12274.276317170314 9903.605140817099 13186.124767253465 0.9239395341989924 1.0849040642400092 0.6542365601470874 0.5668801424603055 0.6405970396041111 0.7396483792799222 0.8946766560501268 0.9308478824386948 0.7510625991809055 1.0 13.686733016882323 -10.681319179302553 11.320800012574221 0.9999999989614761 0.7962402740029036 0.13706867898258612 0.15155276980738075 2.2899313878395339e-10 0.0 0.16414484538051777 0.039810972374241256 2.082959475383858e-11 10.681319179302553 -0.20375972495857242 SVVS(ph)FDK ddPTM_A459_Selumetinib_30min_R2 1 SVVSFDK 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 S(0.073)VVS(0.927)FDK 101.65 0.019789 46068000.0 146360.0 100400.0 165980.0 155520.0 138570.0 136080.0 159520.0 179480.0 107240.0 103220.0 True False 138225.8971255015 108100.35716311802 155301.02750536022 134337.90771303623 121161.59776848227 154823.78478875145 166937.99608288347 180002.25708548664 128690.99653595497 100239.77040223223 1.3789526509372707 1.0784178448268946 1.5492955229464676 1.340165756305889 1.208717830081783 1.5445345112772095 1.6653868560653242 1.7957169730456424 1.2838317168879825 1.0 16.613095489740545 -6.775668650384342 24.936654320099997 1.5205946749810009 1.313029327988707 0.05840990869903162 0.23476225269023143 436.84095825677736 765554.6239732119 0.07990758991425743 0.07079747907334771 1.6762212792151144e-07 6.775668650384342 -0.2075653469922938 SVVS(ph)FDKVK ddPTM_A459_Selumetinib_30min_R2 1 SVVSFDKVK 9 1 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 SVVS(1)FDKVK 70.72800000000002 0.039871 129190000.0 175840.0 148800.0 180360.0 207730.0 169030.0 156000.0 158850.0 157700.0 99552.0 139230.0 True False 166067.516743292 160212.481532589 168755.83396112022 179436.81564576222 147794.94025262736 177487.5839729955 166236.83975530343 158158.8808913597 119465.18171528704 135210.0681370158 1.2282185715268383 1.1849153228015306 1.2481010939962744 1.327096555146537 1.0930764423760118 1.312680234678512 1.229470867412377 1.1697270999899845 0.8835524111579206 1.0 17.04484305734784 -8.141855597810352 4.236291914876527 0.9441121690534771 1.2303746148549126 0.7427936185922551 0.06710973881584696 0.10702429965027115 3.0763223605045065 0.04829085648372111 0.016713659783778523 7.213472860804458e-09 8.141855597810352 0.28626244580143556 SVVSDLEADDVKGS(ph)VPLSSSPPATHFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 1 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 38 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 S(0.025)VVS(0.105)DLEADDVKGS(0.232)VPLS(0.194)S(0.194)S(0.194)PPAT(0.049)HFPDET(0.005)EIT(0.002)NPVPK 57.81100000000001 0.00010247 27006000.0 23612.0 29170.0 28548.0 26040.0 25326.0 14702.0 12469.0 17022.0 7814.1 32907.0 True False 22299.739566325115 31407.245203666822 26711.252760712247 22493.30707849446 22144.321462687338 16727.067048531946 13048.833206854766 17071.531201856204 9377.13834419626 31956.889407346018 0.6978069511733834 0.9828004472940709 0.8358527145815405 0.7038640961508558 0.6929435834764619 0.5234260079357677 0.40832613714447424 0.5342050342963581 0.293430885111137 1.0 14.963839366820473 -6.327901521886511 1.451052491518982 0.5138857815862015 0.8486251215258991 0.2855157347332338 0.18650161317265998 0.4290359300561685 1.8167589230199988 0.06806629970890729 0.0889375112597595 4.700006711661627e-07 6.327901521886511 0.3347393399396976 SVVSDLEADDVKGSVPLS(ph)SSPPATHFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 3 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 38 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 SVVSDLEADDVKGS(0.001)VPLS(0.31)S(0.31)S(0.31)PPAT(0.064)HFPDET(0.004)EIT(0.001)NPVPK;SVVS(0.001)DLEADDVKGS(0.059)VPLS(0.226)S(0.226)S(0.226)PPAT(0.226)HFPDET(0.025)EIT(0.012)NPVPK;SVVSDLEADDVKGS(0.005)VPLS(0.309)S(0.309)S(0.309)PPAT(0.066)HFPDETEITNPVPK 76.956 6.0378e-07 54926400.0 162122.7 238665.0 225880.3 228825.0 224584.4 133220.8 80415.8 107382.5 65746.8 230523.6 True False 153112.56936258922 256969.83807107087 211347.4074178751 197658.6402548577 196370.09986198973 151570.75594198497 84155.29404088469 107694.96529687018 78897.99711907998 223867.78469575697 0.6839419506950221 1.1478643004409972 0.9440724475167455 0.8829257881989662 0.8771699783819391 0.677054789942082 0.37591515972364786 0.48106504222226915 0.352431222859085 1.0 17.772287409042697 -6.873626931853169 2.7412168739593095 0.5090600137889434 0.9272235453309098 0.40828619174548864 0.19936417575394988 0.2271672216676367 3.4563000751571415 0.07308994317997863 0.0635232045005668 1.3377441736586598e-07 6.873626931853169 0.4181635315419664 SVVSDLEADDVKGSVPLSSSPPAT(ph)HFPDET(ph)EITNPVPK ddPTM_A459_Selumetinib_30min_R2 1 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 38 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 2 S(0.014)VVS(0.087)DLEADDVKGS(0.197)VPLS(0.178)S(0.178)S(0.155)PPAT(0.395)HFPDET(0.634)EIT(0.161)NPVPK 46.416 0.015565 5814700.0 16688.0 17579.0 18250.0 15556.0 16997.0 10409.0 10254.0 11239.0 8195.5 17637.0 True False 15760.547767356997 18927.252774606062 17075.814869097605 13437.245964403213 14861.68490489206 11842.745266505846 10730.83131791554 11271.703629283396 9834.829001402652 17127.77398357072 0.9201749031996106 1.1050620350759786 0.9969663825244917 0.7845296170589633 0.8676950617837241 0.6914351671072743 0.6265164012678327 0.6580950706201182 0.5742035719782619 1.0 14.064050042848548 -6.090045398025561 1.1662349367284774 0.68706097638362 1.0290385856146427 0.4787542715962688 0.12485726442312427 0.36740142896999345 1.0221534907655818 0.04754517693164608 0.08425756639022941 8.127455531413654e-07 6.090045398025561 0.3419776092310227 SVVSDLEADDVKGSVPLSSSPPAT(ph)HFPDETEITNPVPK ddPTM_A459_Selumetinib_30min_R2 1 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 38 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 SVVSDLEADDVKGS(0.005)VPLS(0.149)S(0.149)S(0.149)PPAT(0.539)HFPDET(0.007)EIT(0.003)NPVPK 75.127 1.0009e-06 23372000.0 51647.0 80215.0 74003.0 66672.0 65001.0 44655.0 25451.0 31315.0 16426.0 74538.0 True False 48776.66649932207 86367.23256812246 69241.7275483741 57591.158584384844 56834.99326368711 50805.82091226999 26634.521930199753 31406.121465522672 19711.65898078701 72385.89426701776 0.673842148297488 1.1931500390052543 0.9565638201961637 0.7956130012284167 0.7851666935830571 0.7018746045307807 0.3679518254198819 0.43387073936907483 0.2723135381608254 1.0 16.14342096838132 -6.729037154586993 1.4194790768832288 0.4747395251666518 0.9382491168600362 0.3635199032020998 0.22236206334805322 0.3725367960269241 1.567103876973378 0.09726726861591428 0.09047565044730813 1.866220025899264e-07 6.729037154586993 0.4635095916933844 SVWGSLAVQNS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 SVWGSLAVQNSPK 13 0 P18615;P18615-3;P18615-4 P18615 NELFE Negative elongation factor E 1 SVWGSLAVQNS(1)PK;SVWGSLAVQNS(1)PK 192.46 0.00017919 118615000.0 5465.4 6116.4 7587.700000000001 7352.4 5647.0 5808.0 5238.200000000001 5130.6 3899.0 5724.1 True False 5592.733186182852 5400.289044562783 6557.332016252691 6068.441361641226 5136.2298470588275 5749.576793242069 4843.078356700985 4994.519821462479 6616.318228307091 6458.843992455617 0.8659031233322181 0.8361076766787833 1.0152485528234023 0.9395553397372024 0.7952243238973266 0.8901866649756486 0.7498367141795096 0.7732838612136209 1.0243811796716897 1.0 12.657060258313255 -3.4944315131259494 15.293543473998376 0.879684040090035 0.2567792908177299 0.0 0.09741118522067609 0.0 0.0 0.022429371823758457 0.0 0.00032030851712621045 3.4944315131259494 -0.6229047492723051 SVWGSLAVQNS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SVWGSLAVQNSPK 13 0 P18615;P18615-3;P18615-4 P18615 NELFE Negative elongation factor E 1 SVWGSLAVQNS(1)PK;SVWGSLAVQNS(1)PK 168.1 0.00028865 54402000.0 126469.0 126407.0 129826.0 124884.0 121170.0 89044.0 108480.0 103513.0 71605.0 106691.0 True False 119440.35927551954 136102.01043743288 121473.13650386129 107874.58376308385 105947.54132645598 101309.00273904769 113524.53494904214 103814.20569250036 85928.00081086394 103610.55361349117 1.1527817882440807 1.3135921553430536 1.1724011914558887 1.041154399825902 1.0225554987543326 0.9777865208304052 1.0956850532092908 1.0019655534297103 0.8293363737000169 1.0 16.66081143566968 -5.752556003871832 2.434093379956349 0.9942393361119767 1.2371184212549455 0.6649347438648946 0.07218439917131807 0.1705347192446946 2.059511437869623 0.021553766146449948 0.040028638637947624 1.7678442330146264e-06 5.752556003871832 0.24287908514296885 SVYATMGDHENRS(ph)PVKEPVEQPR ddPTM_A459_Selumetinib_30min_R1 1 SVYATMGDHENRSPVKEPVEQPR 23 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 SVY(0.003)AT(0.024)MGDHENRS(0.973)PVKEPVEQPR 59.574 0.004830699999999999 25043000.0 2241.4 2403.7 2403.8 2953.6 2234.2 2471.7 2099.3 1972.3 1252.6 2563.9 True False 2293.6202589948125 2122.2736865501856 2077.37716312825 2437.8092059386777 2032.1170044800467 2446.8369421240404 1940.948110843874 1919.9881970667077 2125.5707137156865 2893.0015395008745 0.7928168124620243 0.7335888548874877 0.7180698436429649 0.8426574174444682 0.7024251376066136 0.8457779606111754 0.6709115374956707 0.6636664968377308 0.7347285110959215 1.0 11.498351375655036 -10.580228796869749 4.550862335832003 1.0000092869203012 0.7438536756489219 0.6135309160449128 0.06071938087306473 43167979.69092107 0.6788546623276106 5944.065365536785 0.014745595492132339 2.6288826678459227e-11 10.580228796869749 -0.2561556112713793 SVYATMGDHENRS(ph)PVKEPVEQPR ddPTM_A459_Selumetinib_30min_R2 1 SVYATMGDHENRSPVKEPVEQPR 23 2 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 SVYATMGDHENRS(0.999)PVKEPVEQPR 56.74800000000001 0.006688899999999999 29390000.0 34182.0 37094.0 43886.0 48968.0 43342.0 24587.0 34775.0 30703.0 27893.0 39381.0 True False 32282.30128138763 39938.99052399099 41062.42253946395 42298.47392548836 37896.9904776038 27973.636071436187 36392.10640535526 30792.340646844736 33472.37939553706 38243.96820587397 0.8441148446627283 1.0443212981715815 1.0736967021418318 1.1060168677525375 0.9909272561256633 0.7314522363591877 0.9515776764965964 0.8051554818026252 0.87523290510413 1.0 15.22294460511487 -6.545863309754931 24.043345546510952 0.864964753159713 1.0262132161344133 0.35089852651982545 0.09452804673173634 149.71280562630218 156607.68430198217 0.03033309164288835 0.030335378914348482 2.8453565166592066e-07 6.545863309754931 0.1612484629747003 SVYFKPSLT(ph)PSGEFR ddPTM_A459_Selumetinib_30min_R1 1 SVYFKPSLTPSGEFR 15 1 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 SVYFKPS(0.004)LT(0.994)PS(0.003)GEFR 129.38 0.009209299999999998 9762200.0 976.17 1110.1 1178.5 1113.9 886.31 716.13 736.07 965.81 473.24 854.8 True False 998.9128617038305 980.1289759285107 1018.4661730371251 919.3782754926506 806.1434169907395 708.9263823940156 680.5476472866428 940.1935814069847 803.0537159179406 964.5219064570957 1.0356559607578644 1.016181145671168 1.0559285032500494 0.9531958469141797 0.8357958607201409 0.735002883447262 0.7055802908473549 0.9747768040443224 0.8325925109028743 1.0 9.913670195263318 -6.082037557113394 3.0192569212360567 0.8333082512129194 1.0327950980614042 0.48736924727169484 0.08658076854995704 0.21948645556348256 3.887567189284016 0.027418982621718747 0.03830023644920933 8.278705676535952e-07 6.082037557113394 0.19948684684848483 SWCS(ph)CS(ph)MS(ph)S(ph)LASSTRLPRK ddPTM_A459_Selumetinib_30min_R1 1 SWCSCSMSSLASSTRLPRK 19 2 Q8NFM4-2 Q8NFM4-2 4 S(0.04)WCS(0.968)CS(0.989)MS(0.986)S(0.97)LAS(0.022)S(0.022)T(0.003)RLPRK 57.499 0.01888 4103700.0 549.83 503.73 776.42 722.12 520.5 449.76 412.62 350.13 271.96 351.21 True False 562.6399692170597 444.7530574222761 670.9864285697792 596.015297871221 473.4208669017386 445.2358227494067 381.49574119773223 340.84341501747497 461.49625682749365 396.29122457510124 1.4197638865718403 1.1222884329551708 1.6931649932173058 1.5039830834262393 1.1946286910827633 1.123506641427105 0.9626651248883128 0.8600831759091392 1.1645381684197134 1.0 8.630417210570009 -6.630549646884636 2.1240772180240337 0.9960107729465463 1.4272483603565602 0.6187897115516786 0.1523372971869891 0.21728513077320266 2.0018020923311477 0.05953292642840425 0.05977202526724452 2.341263815543168e-07 6.630549646884636 0.43123758741001395 SWDSS(ph)SPVDRPEPEAAS(ph)PTTR ddPTM_A459_Selumetinib_30min_R2 1 SWDSSSPVDRPEPEAASPTTR 21 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 2 S(0.004)WDS(0.23)S(0.633)S(0.228)PVDRPEPEAAS(0.853)PT(0.047)T(0.005)R 71.097 0.011168 26978000.0 61989.0 68068.0 66295.0 87676.0 89096.0 67675.0 58308.0 65159.0 62418.0 70483.0 True False 58543.899541628256 73288.59672688338 62029.65187653841 75734.37755046373 77902.96395165399 76996.61695751584 61019.4375351101 65348.60190234688 74903.34410463687 68447.97265317308 0.8553050919166165 1.0707197581765906 0.9062306664777874 1.1064517269811769 1.138133986033297 1.1248925859011027 0.8914718021568954 0.9547193199347078 1.0943106304137487 1.0 16.062720190769248 -4.753302833433088 24.786892912335674 1.0307091111184923 0.8553047315452232 0.27650157568378 0.08566971442475428 397.22572408514264 1209988.5669441514 0.022514129604269656 0.2425312996886735 1.764806792205432e-05 4.753302833433088 -0.17540437957326904 SWDSS(ph)SPVDRPEPEAASPTTR ddPTM_A459_Selumetinib_30min_R1 2 SWDSSSPVDRPEPEAASPTTR 21 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 S(0.001)WDS(0.089)S(0.455)S(0.455)PVDRPEPEAASPTTR;SWDS(0.127)S(0.795)S(0.078)PVDRPEPEAASPTTR 247.91 3.8604999999999995e-38 168327000.0 2446.2 2724.0 2865.9 3222.8999999999996 2720.9 2370.3 2671.8 2614.79 1294.74 2112.6 True False 2503.191700523382 2405.072813646758 2476.7265212618554 2660.0810163257574 2474.7950754139124 2346.4569340602043 2470.2639749214786 2545.4372751650626 2197.07921593186 2383.772788466611 1.050096600076381 1.0089354259278411 1.0389943761607574 1.1159121495119024 1.038184128700392 0.9843458845629283 1.036283318138934 1.0678187482803023 0.9216814734029899 1.0 11.219031015187793 -6.539928549214628 17.96556587988011 1.0087227478810121 1.0527399575687917 0.23819434443767307 0.04313225561700136 16.11130284961231 16973.202777080067 0.014400938493722681 0.014420271866733125 2.8845060273875014e-07 6.539928549214628 0.04401720968777956 SWDSS(ph)SPVDRPEPEAASPTTR ddPTM_A459_Selumetinib_30min_R2 3 SWDSSSPVDRPEPEAASPTTR 21 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 S(0.004)WDS(0.05)S(0.473)S(0.473)PVDRPEPEAASPTTR;S(0.011)WDS(0.127)S(0.431)S(0.431)PVDRPEPEAASPTTR;S(0.126)WDS(0.126)S(0.576)S(0.17)PVDRPEPEAAS(0.001)PTTR 128.72 0.00027704 73083000.0 57100.0 49569.0 59728.0 69221.0 67921.0 44911.0 45773.0 59697.0 52091.0 52225.0 True False 53926.6105894106 53370.78291054372 55885.16550692943 59792.98038711469 59388.15675855584 51097.082588533405 47901.5351974788 59870.708386629645 62510.655544148 50717.12855315424 1.0632820139431327 1.0523226458810324 1.1018992419564686 1.1789504274566427 1.1709684371486824 1.0074916314511173 0.9444843697583442 1.180483006325604 1.2325353845423943 1.0 15.630185446410966 SWDSSS(ph)PVDRPEPEAASPTTR ddPTM_A459_Selumetinib_30min_R1 1 SWDSSSPVDRPEPEAASPTTR 21 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 S(0.001)WDS(0.11)S(0.405)S(0.484)PVDRPEPEAASPTTR 90.378 0.00040723 152670000.0 1028.5 1106.4 1314.7 1549.4 1288.2 1010.9 1038.6 1250.1 715.09 877.69 True False 1052.4620488873759 976.8621736485941 1136.170961130173 1278.8263758401233 1171.6825374501825 1000.7312638237618 960.2575658183429 1216.9432871029205 1213.4555018928231 990.3500609245768 1.0627172051716867 0.9863806871851044 1.1472417743575034 1.2912872188307123 1.1830993743326639 1.0104823570056563 0.969614284591309 1.2288011432712989 1.2252793731945228 1.0 9.95179475728234 -5.270642668903557 24.285052962302903 1.1375250388582154 1.0245489469410598 0.14433253623344955 0.1039264307521967 783.9416898212176 2068622.2353305286 0.029328394876734467 0.06253738862141955 5.36237684513698e-06 5.270642668903557 -0.11297609191715563 SWDSSS(ph)PVDRPEPEAASPTTR ddPTM_A459_Selumetinib_30min_R2 1 SWDSSSPVDRPEPEAASPTTR 21 1 C9J0I9;Q86WB0;Q86WB0-2 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 S(0.005)WDS(0.009)S(0.043)S(0.942)PVDRPEPEAASPTTR 136.85 0.00015113 29412000.0 36707.0 43759.0 42584.0 47867.0 50134.0 36109.0 41726.0 45005.0 38000.0 55941.0 True False 34666.9718897635 47115.1745926382 39844.19180195353 41347.432024819274 43835.71871635341 41082.68698513396 43666.34167850042 45135.957099021165 45601.06180871215 54325.83797782675 0.6381304583633469 0.8672700936866984 0.7334298610951212 0.7611006762876875 0.8069036824474772 0.7562273959198196 0.8037858835481373 0.8308377519633207 0.8393991423993193 1.0 15.729350902745809 -14.522878745280334 0.13795955032217547 1.7705008747105795 0.7020248089189601 0.6590021625052276 0.052560552576791535 83.10723567743968 0.7042178055138091 17.44355314627147 0.3168996368163041 3.000000000000026e-15 14.522878745280334 -1.0684760657916192 SWEDS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 SWEDSPER 8 0 Q9UDY2-7;Q9UDY2-4;A0A3B3IU51;A0A1B0GTW1;A0A2R8YDH4;A0A3B3ITE1;Q9UDY2-2;Q9UDY2-6;Q9UDY2-3;Q9UDY2;Q9UDY2-5;A0A3B3IRV6;A0A3B3ISF1;A0A3B3ISZ5;A0A3B3IRI3;A0A3B3IU26;B1AN86 Q9UDY2-7 TJP2 Tight junction protein ZO-2 1 S(0.001)WEDS(0.999)PER 109.83 0.012283 9199800.0 61420.0 54460.0 53982.0 59852.0 66134.0 39128.0 41015.0 49939.0 41145.0 47418.0 True False 58006.522283740785 58636.90688349997 50508.856891157615 51700.0543495411 57825.655674538575 44517.52683138061 42922.278769680684 50084.31422215349 49375.149687354264 46048.91913324015 1.2596717442140593 1.2733611990726021 1.0968521702976972 1.1227202575580477 1.255744038361097 0.9667442291657586 0.9321017643321291 1.087632786281848 1.0722325434933626 1.0 15.490879673120894 -6.764252850707817 24.999999239611395 1.0122417681066391 1.195443443196067 0.6580208745507018 0.0683860815761987 52.64359322581164 467777.04084557324 0.02573124642567091 0.023701750405311858 1.7208663771903087e-07 6.764252850707817 0.18320167508942786 SWGHES(ph)PEER ddPTM_A459_Selumetinib_30min_R1 2 SWGHESPEER 10 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 S(0.03)WGHES(0.97)PEER;S(0.197)WGHES(0.803)PEER 107.39 0.011322 49248000.0 6179.5 6791.0 6014.700000000001 7518.8 12113.599999999999 5792.5 9795.099999999999 6895.700000000001 1667.6699999999998 3638.1 True False 6323.470326786133 5995.906562949751 5197.936776382177 6205.782725356082 11017.927018829787 5734.232709169196 9056.247720919746 6712.803635609642 2829.9141882023328 4105.085573094945 1.540399149832748 1.4606045248477635 1.266218860442244 1.5117304170293724 2.6839701201461303 1.3968607004813274 2.206104491529996 1.635240853346855 0.6893678920482958 1.0 12.003196580865641 -8.21968209509475 6.67295656919089 0.845133380607804 1.723295376562788 0.4188969942239811 0.40903316388454664 0.19119209847094784 24.34132951097306 0.29747679300936075 0.1074067436996246 6.030008230304852e-09 8.21968209509475 0.8781619959549841 SWGHES(ph)PEER ddPTM_A459_Selumetinib_30min_R2 2 SWGHESPEER 10 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 SWGHES(1)PEER;S(0.45)WGHES(0.55)PEER 94.688 0.01559 22311900.0 94854.0 93697.0 139784.0 164044.0 177984.0 134449.0 98913.0 106975.0 104112.0 145654.0 True False 89582.3944106472 100883.25861665967 130790.44962531171 141700.92420831556 155624.05872285165 152968.12934349533 103512.65049239121 107286.2795393353 124937.30913233272 141448.59056545954 0.6333212232976637 0.7132150148217485 0.9246500732348022 1.0017839247591458 1.1002163973548538 1.0814397565361726 0.7318040432823377 0.7584824925468974 0.8832700886794221 1.0 17.109918275813236 -5.183976474809995 3.30323833940353 0.9339969841355079 0.6483115059424852 0.4579839996183257 0.11538328888004898 0.26043696279139633 5.436253915454235 0.03513052282210602 0.11299561532991581 6.5467163585216865e-06 5.183976474809995 -0.2856854781930227 SWMDDY(ph)DYVHLQGK ddPTM_A459_Selumetinib_30min_R1 1 SWMDDYDYVHLQGK 14 0 A0A087WUD2;Q14511-3;Q14511 A0A087WUD2 NEDD9 Enhancer of filamentation 1;Enhancer of filamentation 1 p55 1 S(0.001)WMDDY(0.958)DY(0.041)VHLQGK 105.03 0.038977 2664400.0 1619.6 2582.5 1857.7 1404.2 1800.3 1867.8 1929.0 1935.2 1117.5 1951.6 True False 1657.3335288069948 2280.1396994283214 1605.434543615671 1158.982830098554 1637.4631828687811 1849.01162782671 1783.49397695319 1883.8722095844914 1896.3158810292832 2202.106870193808 0.7526126689124458 1.0354355323489117 0.7290447913067799 0.5263063504254685 0.7435893348467087 0.8396557191904034 0.8099034615864145 0.8554862777475879 0.861137080446231 1.0 11.104668770529534 -8.463236497067777 0.7913765048164685 0.9955633850165853 0.7692075028943378 0.26100364323855674 0.11753682411947577 1.0434831835865228 1.4750653974342287 0.12452841780307045 0.04662972681877474 3.4416246446413265e-09 8.463236497067777 -0.22635588212224744 SWQQTTFQNRPDS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 SWQQTTFQNRPDSR 14 1 Q9BYW2;H7C3H4;C9JG86;Q9BYW2-3;Q9BYW2-2;H7BZ93;H7BXT4 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 1 SWQQTTFQNRPDS(1)R 112.02 0.021844 0.0 15122.0 11512.0 13163.0 13208.0 14530.0 10607.0 10826.0 11669.0 7661.5 12859.0 True False 14281.579778162302 12394.933383085787 12316.106910790784 11409.047614929139 12704.611500151892 12068.017969240806 11329.43045131203 11702.95485809306 9194.014080196004 12487.72725830561 1.1436492391891084 0.9925691942736734 0.9862568789368233 0.9136208197805539 1.0173677913810963 0.9663902581804343 0.9072451869716169 0.9371565070264811 0.7362439849958325 1.0 13.608223312738087 -1.5228787452879626 0.4470005030062259 0.9073840589438671 5.656315859484311 0.4503894249911454 0.07261206225771107 82.85750519368011 1.0047936105081732 0.04545562305669603 358.44043223617234 0.029999999999473278 1.5228787452879626 4.7489318005404435 SWS(ph)LATFR ddPTM_A459_Selumetinib_30min_R1 2 SWSLATFR 8 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 SWS(0.996)LAT(0.004)FR;S(0.001)WS(0.996)LAT(0.003)FR 101.38 0.017079 13958900.0 6350.4 10586.2 8027.5 11126.7 7678.6 9295.4 7692.900000000001 5362.2 3810.6000000000004 5630.7 True False 6498.35196427262 9346.762782609145 6937.409591901163 9183.630719026905 6984.071985766939 9201.89671554792 7112.618359410682 5219.977037119656 6466.309884787639 6353.455192662571 1.022805979930005 1.4711306681447067 1.0919113114881152 1.4454545504047664 1.0992557236938807 1.4483295209471116 1.119488238088914 0.8215965767962073 1.0177627273196796 1.0 12.633325669245716 -7.535371507760111 7.0645979444281695 0.94402812901068 1.2673822882297086 0.4480631433341177 0.1576279404381203 0.12009965362457799 30.63371171958583 0.06611087044792137 0.0391805387428388 2.9149324316935505e-08 7.535371507760111 0.32335415921902855 SWS(ph)PPPEVSR ddPTM_A459_Selumetinib_30min_R1 4 SWSPPPEVSR 10 0 Q9NR19;Q9NR19-2;F8WCJ4;C9JXD9;C9IYL0;B4DEH9;C9JY31 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 S(0.025)WS(0.975)PPPEVSR;S(0.002)WS(0.998)PPPEVSR;SWS(1)PPPEVSR;S(0.053)WS(0.947)PPPEVSR 169.21 0.00024231 305702800.0 13521.7 15916.5 17124.899999999998 17911.8 16949.199999999997 14212.099999999999 16372.4 14820.999999999998 8005.300000000001 11992.4 True False 13836.729301351897 14052.988780619891 14799.432640342346 14783.840376128244 15416.147852624303 14069.139177554342 15137.416686505145 14427.89893460715 13584.409416021235 13531.741355868122 1.022538706398753 1.0385203508582972 1.0936827900515909 1.0925305167554908 1.1392582408426686 1.039713870340359 1.1186599188093935 1.066226330756049 1.0038921864354342 1.0 13.724059886552153 -8.23166782108359 4.148393919451257 0.9998302628399585 1.0791632405126261 0.42694716078708583 0.03465398173468823 0.20048037782424208 7.741472225078751 0.029409883303659595 0.009258314900935724 5.865866556384223e-09 8.23166782108359 0.07933297767266767 SWS(ph)PPPEVSR ddPTM_A459_Selumetinib_30min_R2 1 SWSPPPEVSR 10 0 Q9NR19;Q9NR19-2;F8WCJ4;C9JXD9;C9IYL0;B4DEH9;C9JY31 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 S(0.125)WS(0.875)PPPEVSR 119.27 0.0054512 110670000.0 62450.0 59945.0 77451.0 69954.0 77735.0 56720.0 52323.0 56852.0 50914.0 60667.0 True False 58979.27900715752 64542.588746445195 72467.88698227295 60426.144522619106 67969.23434028267 64532.66514710456 54756.12317605762 57017.429907644735 61098.22265602028 58915.386078204065 1.0010844862981743 1.095513295300681 1.2300333037974043 1.0256428506198647 1.1536754465134211 1.0953448571387472 0.9294027727048167 0.967785050783848 1.0370503653310315 1.0 15.846356830582812 -7.194713776361478 7.616169698179014 0.9810460505729923 1.1053508217093964 0.4384869967169429 0.06451245955504849 0.26877088036508273 27.573854279128444 0.02472951176610228 0.019101283453561844 6.386842751211535e-08 7.194713776361478 0.12430477113640404 SWS(ph)T(ph)ATSPLGGERPFRY(ph)GPR ddPTM_A459_Selumetinib_30min_R2 1 SWSTATSPLGGERPFRYGPR 20 2 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 3 S(0.162)WS(0.792)T(0.693)AT(0.177)S(0.177)PLGGERPFRY(0.999)GPR 48.31399999999999 0.03993 7821500.0 50467.0 42722.0 51692.0 51561.0 61467.0 47505.0 56093.0 52592.0 47163.0 51896.0 True False 47662.2461754078 45998.640027118716 48366.19299799414 44538.302852313835 53744.96593804794 54048.38254254587 58701.43564617089 52745.034012925724 56596.91784432346 50397.6276379989 0.9457240034741503 0.9127143911916317 0.9596918598114111 0.8837380833127304 1.066418568828133 1.0724390229391347 1.1647658510400014 1.0465777157565432 1.123007579857795 1.0 15.621068203047486 -6.344701581400937 5.3982302012293415 1.086986562186132 0.9273045282515 0.7332432766366583 0.04524715336412576 0.10750201581837542 5.2646269996530775 0.01345433477725361 0.015343799231908354 4.521665367528669e-07 6.344701581400937 -0.1596820339346321 SWSTAT(ph)SPLGGERPFR ddPTM_A459_Selumetinib_30min_R2 1 SWSTATSPLGGERPFR 16 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;Q9UPQ0-5;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 S(0.118)WS(0.03)T(0.118)AT(0.472)S(0.262)PLGGERPFR 92.427 0.014951 8956800.0 17021.0 19400.0 18870.0 19694.0 18086.0 16547.0 14726.0 20081.0 15415.0 23526.0 True False 16075.040960461616 20887.917619168187 17655.92474410256 17011.643225955057 15813.874989108537 18826.19905128948 15410.788179015426 20139.43238541148 18498.430731086795 22846.743252111173 0.7036031693040621 0.9142623694183643 0.7727983174350703 0.7445981704365273 0.6921719570533206 0.8240211238663011 0.6745288818173846 0.8815012346913156 0.8096747324972644 1.0 14.479700906806878 -8.821125580797151 1.0193867664192588 0.9987161187176268 0.7696956781812999 0.4644712552375062 0.07347598916139057 0.920250554877082 1.7406834568918854 0.06908242457437291 0.022202942632881396 1.5096435618004567e-09 8.821125580797151 -0.22902044053632686 SWSTATS(ph)PLGGER ddPTM_A459_Selumetinib_30min_R2 1 SWSTATSPLGGER 13 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 SWS(0.02)T(0.083)AT(0.234)S(0.663)PLGGER 127.79 0.0018913 2665700.0 19060.0 19111.0 20298.0 22400.0 23593.0 21040.0 26026.0 22759.0 24963.0 19429.0 True False 18000.721503225337 20576.752248449655 18992.048778791406 19349.081357844694 20629.036415903895 23938.069017896327 27236.26056954063 22825.224922044727 29956.297524496895 18868.03428739557 0.9540326898414836 1.0905615251184677 1.0065727298088853 1.0254953464214593 1.0933325698737324 1.268710277566524 1.4435134129332854 1.2097298835890224 1.587674532927292 1.0 14.203656507228272 -6.741098870485348 2.792552898573067 1.3313912951588072 1.0259158262934038 0.46121168686000913 0.14604318854972445 0.21840148775169377 3.49291079678371 0.050009857322880734 0.046986470518456246 1.815102393686419e-07 6.741098870485348 -0.30547546886540333 SWSTATS(ph)PLGGERPFR ddPTM_A459_Selumetinib_30min_R1 4 SWSTATSPLGGERPFR 16 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;Q9UPQ0-5;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 SWSTAT(0.072)S(0.928)PLGGERPFR;S(0.006)WS(0.005)T(0.007)AT(0.076)S(0.907)PLGGERPFR;SWSTAT(0.02)S(0.98)PLGGERPFR;S(0.002)WS(0.009)T(0.007)AT(0.032)S(0.95)PLGGERPFR 241.27 7.299000000000001e-21 172918500.0 10900.800000000001 12623.560000000001 13427.6 14041.900000000001 12498.9 10655.9 12314.699999999999 11492.8 6801.9400000000005 8361.88 True False 11154.767430735541 11145.587726666166 11604.205672527192 11589.745764108307 11368.376701860027 10548.711320783084 11385.792264378144 11187.973610124354 11542.395385958236 9435.208749608626 1.1822491400837574 1.1812762200018614 1.229883299933193 1.228350752132437 1.2048887315112757 1.1180156794327043 1.206734537256574 1.1857685300909144 1.2233322751271418 1.0 13.203838721798205 -11.30028025171956 2.819388413497837 0.9539902213859122 1.1951886839527064 0.7797233081662184 0.03119022137319499 71535319.57114168 59543353.24050912 22771203.441078752 0.008144704975022494 5.008639201143454e-12 11.30028025171956 0.24119846256679423 SWSTATS(ph)PLGGERPFR ddPTM_A459_Selumetinib_30min_R2 2 SWSTATSPLGGERPFR 16 1 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;Q9UPQ0-5;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46;D6RJ93;Q6NVB9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 SWST(0.001)AT(0.066)S(0.933)PLGGERPFR;SWSTAT(0.039)S(0.961)PLGGERPFR 221.78 2.9568e-10 33427000.0 92144.0 88535.0 90442.0 97093.0 115902.0 77657.0 78035.0 83266.0 83823.0 106267.0 True False 87023.00536165755 95325.3498151059 84623.0601858041 83868.76590523287 101341.35458297354 88353.54684994178 81663.78212341902 83508.29027457157 100589.94221030716 103198.79559517559 0.8432560172797768 0.9237060303401665 0.8200004631619957 0.8126913247537322 0.9820013305243566 0.856149011627343 0.7913249534787855 0.8091983030708497 0.9747201179061978 1.0 16.6550666079983 -8.367245757974972 5.502721062385834 0.9965685082957682 0.856917581222117 0.4819533413106599 0.055095274723547645 0.20842197241871127 8.580687035984244 0.055181405918124045 0.014372602533848452 4.292934300315478e-09 8.367245757974972 -0.13965092707365112 SWVIGS(ph)PEILR ddPTM_A459_Selumetinib_30min_R1 2 SWVIGSPEILR 11 0 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 SWVIGS(1)PEILR;SWVIGS(1)PEILR 202.0 1.8537e-05 70733000.0 6685.8 7989.5 7641.6 8120.7 8233.900000000001 6960.7 7953.0 7914.5 3714.8999999999996 6552.1 True False 6841.566131697833 7054.085625782214 6603.912692304193 6702.5721894184135 7489.145198813115 6890.68167780993 7353.098807002967 7704.581750080844 6303.9139744390895 7393.1258578586085 0.9253955989976164 0.9541411523900939 0.8932504084567271 0.9065951693888502 1.0129876513399865 0.9320390062730233 0.9945859097186754 1.0421277681741574 0.8526723466689359 1.0 12.851968758118927 -6.243134904425305 24.873637700085105 0.9735995386683476 0.9203956081108345 0.20401317458035972 0.05081997129408561 1260.5292610409272 1712911.6574508296 0.014511892898093045 0.01869504857303336 5.713011464491307e-07 6.243134904425305 -0.053203930557513046 SWVIGS(ph)PEILR ddPTM_A459_Selumetinib_30min_R2 5 SWVIGSPEILR 11 0 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 S(0.001)WVIGS(0.999)PEILR;S(0.188)WVIGS(0.812)PEILR;S(0.298)WVIGS(0.702)PEILR;SWVIGS(1)PEILR;SWVIGS(1)PEILR 134.18 0.0016781 16409800.0 84980.4 78357.7 86954.7 93957.3 102986.2 71324.5 76498.4 79602.2 64776.6 74670.0 True False 80257.52957149466 84367.4836302831 81360.12927111883 81160.15365461711 90048.15284769046 81148.80245565341 80055.7271787039 79833.82922314637 77733.73000942699 72514.08308404085 1.1067854154410182 1.163463427269771 1.1219907335355228 1.1192329848611038 1.2418022681653211 1.1190764470069252 1.1040024747458035 1.1009424077061312 1.0719811477080499 1.0 16.14597359015869 -8.367082376314947 0.8461530142167892 1.0022139340449274 1.1470909026929406 0.5961205845502384 0.037041608503496186 0.4189057347037963 0.6632317304359424 0.03620796503996805 0.013311507219745855 4.294549606770078e-09 8.367082376314947 0.14487696864801314 SY(ph)DVPPPPMEPDHPFYSNISK ddPTM_A459_Selumetinib_30min_R2 1 SYDVPPPPMEPDHPFYSNISK 21 0 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 S(0.422)Y(0.578)DVPPPPMEPDHPFYSNISK 87.24 0.0091225 0.0 7482.1 9388.6 9140.3 6433.3 11417.0 6901.2 5415.4 6690.5 6657.1 12034.0 True False 7066.274835219427 10108.675430892907 8552.223049206177 5557.073441938492 9982.694390724999 7851.777657143828 5667.226830411524 6709.968247328099 7988.706014915205 11686.547151913031 0.6046503508149292 0.8649839254906155 0.7318006711508642 0.4755102914233162 0.8542039201964696 0.6718646281984606 0.4849359487232143 0.5741617399994582 0.6835813787485975 1.0 13.512561120998987 -8.580657220507115 19.59041832157943 1.0000000013211539 0.6602305358548477 0.3941616481434965 0.12655197207021954 3375.2452224568337 1144413.257410577 0.1263085484990023 0.032612727008880425 2.6262906014505884e-09 8.580657220507115 -0.33976946546630615 SYDKPAVDDDDEGMET(ph)LEEDTEESSR ddPTM_A459_Selumetinib_30min_R1 1 SYDKPAVDDDDEGMETLEEDTEESSR 26 1 F5GZI3;Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 F5GZI3;Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 SYDKPAVDDDDEGMET(1)LEEDTEESSR 105.44 4.9134e-08 5646400.0 864.34 960.75 1062.3 1443.5 961.18 909.63 1087.3 1016.6 537.91 995.34 True False 884.4774402871311 848.2649433594423 918.0454947962141 1191.4198228509215 874.2414387101113 900.4799480779579 1005.2840856097474 989.6364656178141 912.7939826080194 1123.1015844326223 0.7875311125430908 0.7552878164515954 0.8174198198286755 1.0608299724310448 0.7784170646965722 0.8017796079709654 0.8950963114504065 0.8811638050691263 0.8127439185023964 1.0 10.133272709933118 -14.522878745280336 0.15553818073449108 1.5310864675809237 0.8042923709334984 0.2434068238251733 0.0833901188910686 216.16925822043694 1.9541443240383454 35.83779189796562 0.4020878313909038 3.0000000000000132e-15 14.522878745280336 -0.7267940966474253 SYEDDDDMDLQPNK ddPTM_A459_Selumetinib_30min_R1 1 SYEDDDDMDLQPNK 14 0 Q9BTE3;Q9BTE3-2 Q9BTE3 MCMBP Mini-chromosome maintenance complex-binding protein 0 143.5 0.012384 0.0 1813.8 2033.4 2160.4 2108.3 2039.5 1736.7 1789.1 1800.6 1164.5 1672.2 False True 1856.0580109595758 1795.3285826979868 1867.0295462277525 1740.1249826924807 1855.0275851029712 1719.2303747974336 1654.1467465873268 1752.842238826908 1976.0714482851017 1886.8431586073416 0.9836843102155411 0.9514985781982532 0.9894990676415238 0.9222414564530356 0.9831381991877624 0.9111676118678453 0.876674215894147 0.9289814210740557 1.0472897226622793 1.0 10.881758790428472 -8.257078081434585 24.992535893176864 1.023644864699355 0.9424957890567304 0.4487013427681035 0.035585993212710616 323.2656099011693 1852510.6483040713 0.027579649143742887 0.009614056548182637 5.532506318141804e-09 8.257078081434585 -0.08114907564262464 SYELPDGQVIT(ph)IGNER ddPTM_A459_Selumetinib_30min_R1 2 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;Q6S8J3;A5A3E0;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;POTEE;POTEF;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 SYELPDGQVIT(1)IGNER;SYELPDGQVIT(1)IGNER 199.01 2.0521e-06 62136000.0 2657.4 3732.6000000000004 4453.7 5162.1 4989.1 3481.3999999999996 4284.8 4351.299999999999 1523.86 2675.6000000000004 True False 2719.312249599722 3295.5854567613396 3848.912002422945 4260.636139618111 4537.836785897145 3446.3802768582877 3961.5940862877274 4235.8893889856345 2585.879121669159 3019.039322551011 0.9007210437067021 1.0916007062725683 1.2748797187479866 1.4112555963722866 1.5030730974589588 1.1415486546051956 1.3122035399460388 1.403058700608913 0.8565238294028437 1.0 11.55987383253048 -8.268822369502073 24.951483504705244 0.9282618751354332 1.261652817250586 0.3720498484471839 0.16949864754761046 680.9005669134717 2301132.821630375 0.1623295476319319 0.04528201674358177 5.384899849122881e-09 8.268822369502073 0.33339094211515286 SYELPDGQVIT(ph)IGNER ddPTM_A459_Selumetinib_30min_R2 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;Q6S8J3;A5A3E0;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;POTEE;POTEF;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 SYELPDGQVIT(1)IGNER 82.12100000000002 0.048015 10059000.0 9551.2 11794.0 13711.0 14768.0 17109.0 10372.0 10767.0 9959.0 9190.2 13590.0 True False 9020.382540482988 12698.561876312864 12828.849187408066 12756.572923779033 14959.614463599362 11800.648852358398 11267.686834405753 9987.979041198801 11028.496795642799 13197.621388939519 0.6834854762573099 0.9621856471011587 0.9720576768598236 0.9665812154961413 1.1335083817555571 0.8941496732318843 0.8537664858190902 0.7568014528412969 0.8356427624818371 1.0 13.687990315223887 -6.996207743197258 24.984030486472506 0.8459535282114884 0.9540968783183496 0.08963934189135492 0.11739193236367955 216.1187216660777 1423812.9057126588 0.04215006027172364 0.037004324662919856 1.0087702290506901e-07 6.996207743197258 0.10814335010686116 SYELPDGQVITIGNER ddPTM_A459_Selumetinib_30min_R1 7 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;Q6S8J3;A5A3E0;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;POTEE;POTEF;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 ;;;;;; 253.97 1.1431e-28 288845500.0 15409.88 15539.77 17390.6 18561.19 18091.14 16169.779999999999 16252.29 15104.519999999997 10241.06 14338.469999999998 False True 15768.900221593185 13720.366504156927 15029.052039727989 15319.826603188287 16454.799581250183 16007.126694185565 15026.366680506257 14703.89906320438 17378.330842571588 16178.952293025115 0.9746552147502958 0.8480380098575292 0.9289261608248355 0.946898558430931 1.0170497621371928 0.9893796832002758 0.9287601822637336 0.9088288782174948 1.0741320283182698 1.0 13.98183056515436 -5.853768811006334 2.927554953590747 0.9790818968811446 0.9085503705059635 0.2552990566834574 0.05191988539878333 0.36200477493138306 6.244389701778345 0.01522661576752071 0.025018610918374106 1.400332566494872e-06 5.853768811006334 -0.07053152637518101 SYELPDGQVITIGNER ddPTM_A459_Selumetinib_30min_R2 3 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;Q6S8J3;A5A3E0;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;POTEE;POTEF;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 ;; 147.52 0.0043621 314290000.0 53446.0 48444.0 64580.0 72364.0 70723.0 46030.0 49361.0 55769.0 49762.0 52081.0 False True 50475.6852812897 52159.49902798884 60424.993109387586 62507.89836513715 61838.14446835809 52370.214681262725 51656.38430696595 55931.27855694504 59715.79046645088 50577.28620731116 0.9979911748209461 1.031283070708704 1.1947061149487475 1.2358887368714015 1.2226465495774095 1.035449281849614 1.0213356267323572 1.105857643838153 1.1806839580455528 1.0 15.626202008873864 -6.790965528225417 24.999427280739333 1.0723233102582628 1.1394126144899206 0.13496007952199096 0.08546439924041856 511.0481151895275 432694.79115118855 0.03352799796329106 0.029573247453107417 1.6182084765396397e-07 6.790965528225417 0.06708930423165782 SYES(ph)SEDCSEAAGSPAR ddPTM_A459_Selumetinib_30min_R1 2 SYESSEDCSEAAGSPAR 17 0 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 SYES(0.862)S(0.138)EDCSEAAGSPAR;SYES(0.793)S(0.207)EDCSEAAGSPAR 220.97 5.5111e-12 28284000.0 4285.8 4538.1 3503.86 3573.2 4847.8 3848.8 4623.4 4301.6 2327.24 4099.0 True False 4385.650801284897 4006.77714229455 3028.055057325296 2949.2076972711548 4409.317345948605 3810.084566430798 4274.6532156793055 4187.507594433986 3949.156305115517 4625.146577641126 0.948218770511188 0.8663027376611379 0.6546938581284133 0.6376463205573221 0.9533356990812178 0.8237759609283521 0.924220053120873 0.9053783537752569 0.8538445731009954 1.0 12.175283372125648 -6.289564201329082 24.968244939738828 0.9017519157844153 0.7743986388422608 0.3126514391285533 0.0963831719453781 992.4005110211806 881016.0639651335 0.03196885835551412 0.03625571126132449 5.133762799791248e-07 6.289564201329082 -0.12735327694215448 SYESS(ph)EDCSEAAGSPAR ddPTM_A459_Selumetinib_30min_R2 1 SYESSEDCSEAAGSPAR 17 0 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 SYES(0.377)S(0.623)EDCSEAAGSPAR 239.58 1.5296e-22 17892000.0 51125.0 39384.0 51975.0 50843.0 55825.0 49551.0 46866.0 50502.0 47086.0 47107.0 True False 48283.67716959052 42404.62616048043 48630.985086101275 43918.09569093291 48811.76441816789 56376.20047080709 49045.361863217215 50648.9524589438 56504.51569276373 45746.89851131523 1.0554524730818162 0.9269399137515715 1.0630444176247857 0.9600234577666511 1.066996146330982 1.2323502205698766 1.0721024475809247 1.1071559844962184 1.235155115024632 1.0 15.48138631630089 -6.5235293976837605 24.999309194880126 1.1343831270432971 1.002086536965638 0.3915380268004567 0.07510770539664546 21.413597462921008 822695.2166493929 0.023191233287011583 0.023397258014157752 2.9955088175710454e-07 6.5235293976837605 -0.13229659007765915 SYESSEDCSEAAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 SYESSEDCSEAAGSPAR 17 0 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 SYESSEDCSEAAGS(1)PAR;SYESSEDCSEAAGS(1)PAR 373.42 4.154899999999997e-222 87234000.0 3057.9 3517.5 3198.5 2862.4 2738.8 2595.81 3053.6 2900.1000000000004 1610.79 2611.7 True False 3129.143120362381 3105.669464758615 2764.161268102881 2362.535573902652 2491.0760235744137 2569.698508206904 2823.2644935325347 2823.1799271475747 2733.3929825531645 2946.9371351123027 1.0618289352287573 1.053863493643974 0.937977683734181 0.8016918806150982 0.8453102015287758 0.8719895913588863 0.9580334985411709 0.9580048021757303 0.9275369162053739 1.0 11.525000569477891 -2.8881028682567766 10.547314525004058 0.9354328378084715 1.0337982156437646 0.0 0.08080445290881984 0.0 0.0 0.02066799806249119 0.0 0.0012938893307528636 2.8881028682567766 0.09836537783529309 SYESSEDCSEAAGS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 SYESSEDCSEAAGSPAR 17 0 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 SYESSEDCSEAAGS(1)PAR;SYESSEDCSEAAGS(1)PAR 262.82 1.9441e-40 88182000.0 34840.6 31336.4 33007.8 41148.1 36410.8 30939.7 33921.5 30249.1 32680.0 30498.5 True False 32904.29892997233 33739.8011175929 30884.11408417533 35543.657795568266 31836.549787318025 35201.36283236725 35498.91696417706 30337.119872991923 39216.91315549248 29617.929060380568 1.110958800086664 1.139168138623375 1.0427506265280553 1.2000723522264916 1.0749080302817415 1.1885153334186203 1.1985617526400045 1.0242822788570118 1.324093695934748 1.0 14.854183147834197 -5.765745426995745 24.999373043873344 1.1465653128727697 1.101780089783464 0.05004563169347964 0.092400576366388 368.2355034056311 2137860.861186126 0.023992636126841774 0.03707772780913905 1.7149622826725123e-06 5.765745426995745 -0.04478522308930577 SYESSEDCSEAAGS(ph)PARK ddPTM_A459_Selumetinib_30min_R1 1 SYESSEDCSEAAGSPARK 18 1 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 SYESSEDCSEAAGS(1)PARK 106.0 0.00086865 11581000.0 1676.2 1891.6 1471.8 1762.3 1804.3 1686.4 1818.7 1567.7 882.62 1696.5 True False 1715.2521986825673 1670.1305926190182 1271.937644018702 1454.5473874680836 1641.101383575037 1669.4363471286886 1681.5139947562297 1526.119503392728 1497.7416759857413 1914.2623003093836 0.8960382275748457 0.8724669510281278 0.6644531649675862 0.7598474813159092 0.8573022533588014 0.8721042810375954 0.8784135771176516 0.79723635739265 0.7824119378748021 1.0 10.902572812201845 -6.2839150115804125 22.530093439653296 0.8555079951979664 0.7939526898264659 0.1335369602685098 0.08058481220578831 534.7444896709911 536037.4335618218 0.026043758479264684 0.0295646839318509 5.200977661029102e-07 6.2839150115804125 -0.061555305371500446 SYESSEDCSEAAGS(ph)PARK ddPTM_A459_Selumetinib_30min_R2 1 SYESSEDCSEAAGSPARK 18 1 Q6P6C2-3;Q6P6C2;K7ER58 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 SYESSEDCSEAAGS(1)PARK 66.308 0.016267 30676000.0 49360.0 40008.0 56986.0 67485.0 57416.0 36270.0 42949.0 59677.0 33826.0 38145.0 True False 46616.76880373572 43076.48495400419 53319.58280166554 58293.42658188168 50202.888774447456 41265.86327372147 44946.213601828975 59850.65018994081 40592.14517740781 37043.65473738762 1.258427904433687 1.1628573168437326 1.4393715517451595 1.5736413427654312 1.355235846202249 1.1139792649042386 1.2133309718078498 1.6156788690057202 1.0957921259437382 1.0 15.176938821867758 -6.565668165276811 24.972427508346815 1.2452536769879665 1.3646252372368293 0.12665680073104923 0.18417868651834976 382.38278183656 223160.7409498595 0.06301068219662107 0.06301073568012572 2.7185156326229635e-07 6.565668165276811 0.11937156024886275 SYGSLVQSACS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 4 SYGSLVQSACSPVR 14 0 Q96S90 Q96S90 LYSMD1 LysM and putative peptidoglycan-binding domain-containing protein 1 1 SYGSLVQS(0.006)ACS(0.994)PVR;SYGSLVQSACS(1)PVR;SYGSLVQS(0.001)ACS(0.999)PVR;SYGSLVQSACS(1)PVR 137.27 0.00058833 15365000.0 6577.9 7657.6 6333.099999999999 7078.700000000001 6694.0 6177.0 6835.6 6016.599999999999 3107.85 5933.400000000001 True False 6731.152271634682 6761.044632078339 5473.099805228183 5842.5379286559155 6088.528881921693 6114.864988267261 6319.985188626871 5857.020223328879 5273.794461616876 6695.009686210259 1.005398436614493 1.0098633084884243 0.8174894528533918 0.8726705714391746 0.9094130056991946 0.9133466977444521 0.9439844727400727 0.874833719119572 0.7877202138302105 1.0 12.708870427476407 -5.238001815294669 24.261165487473804 0.8883079611352208 1.0076309373256158 0.4073501367304483 0.056759630384329386 521.4458800142353 539766.5185878008 0.014281024002126805 0.03772802592307098 5.78093631044186e-06 5.238001815294669 0.119322976190395 SYGSLVQSACS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 4 SYGSLVQSACSPVR 14 0 Q96S90 Q96S90 LYSMD1 LysM and putative peptidoglycan-binding domain-containing protein 1 1 SYGSLVQSACS(1)PVR;SYGSLVQS(0.007)ACS(0.993)PVR;SYGSLVQS(0.003)ACS(0.997)PVR;SYGSLVQSACS(1)PVR 149.6 0.00043698 27169500.0 95521.0 79888.0 98284.0 113902.0 116350.0 91660.0 97227.0 90720.0 71555.8 90492.0 True False 90212.32522085965 86015.15271959302 91960.51444352815 98388.35110809024 101733.07281780262 104285.33299336405 101748.24815164562 90983.98018049554 85868.95943610132 87879.26083354763 1.026548520836231 0.9787878494166512 1.0464416014799083 1.1195855560784462 1.1576459775930017 1.1866887819060201 1.15781866149702 1.0353293748433838 0.9771242796266342 1.0 16.42323511462402 -5.554749772630808 4.214155664027707 1.1013209559490758 1.0037492143790079 0.20534067319003668 0.06726649512202756 0.29491006688424387 11.795157784471412 0.020089736677041094 0.03819283371933826 2.787726910080033e-06 5.554749772630808 -0.09757174157006787 SYIEGYVPSQADVAVFEAVS(ph)SPPPADLCHALR ddPTM_A459_Selumetinib_30min_R2 2 SYIEGYVPSQADVAVFEAVSSPPPADLCHALR 32 0 P24534;C9JZW3;F2Z2G2 P24534 EEF1B2 Elongation factor 1-beta 1 SYIEGYVPSQADVAVFEAVS(0.549)S(0.451)PPPADLCHALR;SYIEGYVPSQADVAVFEAVS(0.615)S(0.385)PPPADLCHALR 84.01100000000002 2.8369e-05 0.0 8260.5 4662.3 7275.9 7651.4 7778.400000000001 5988.1 4303.6 5684.799999999999 6735.6 5742.5 True False 7801.4144794015165 5019.883418342676 6807.776515400948 6609.266120598786 6801.207852221711 6812.906420440359 4503.725927421621 5701.341826830694 8082.908208388466 5576.699104193169 1.3989305023711185 0.9001531774536987 1.2207537807234607 1.1851573838059903 1.2195759041594736 1.2216736627080482 0.8075970826604632 1.0223506271915954 1.4494072671611162 1.0 12.44519571583442 SYIEGYVPSQADVAVFEAVSS(ph)PPPADLCHALR ddPTM_A459_Selumetinib_30min_R1 1 SYIEGYVPSQADVAVFEAVSSPPPADLCHALR 32 0 P24534;C9JZW3;F2Z2G2 P24534 EEF1B2 Elongation factor 1-beta 1 SYIEGYVPSQADVAVFEAVS(0.045)S(0.955)PPPADLCHALR 154.8 5.473200000000002e-22 17119000.0 1278.6 1673.9 1417.4 1553.3 1414.0 1452.0 1527.1 1249.0 858.66 1214.8 True False 1308.3888922774906 1477.9190098250015 1224.9248652208914 1282.0453140521897 1286.1039496619765 1437.3941983105171 1411.9096175247364 1215.8724626762244 1457.0833059549025 1370.7314131540472 0.9545187917353505 1.0781973737833264 0.8936286521677828 0.9353001629270382 0.9382610898970037 1.0486330031665934 1.0300410452226656 0.8870245848371614 1.0629969459897033 1.0 10.420730195770966 -6.7344313311387785 24.9993121260598 1.0001970858971143 0.9614913627482014 0.11377275494194161 0.06283985052410647 623.4331255912767 577063.2705540718 0.02109356757865841 0.02108848227646911 1.8431839026060079e-07 6.7344313311387785 -0.03870572314891296 SYIEGYVPSQADVAVFEAVSS(ph)PPPADLCHALR ddPTM_A459_Selumetinib_30min_R2 1 SYIEGYVPSQADVAVFEAVSSPPPADLCHALR 32 0 P24534;C9JZW3;F2Z2G2 P24534 EEF1B2 Elongation factor 1-beta 1 SYIEGYVPSQADVAVFEAVS(0.111)S(0.889)PPPADLCHALR 93.759 2.3039e-08 1429200.0 2655.8 2451.2 3375.2 2746.3 3282.5 4012.5 2277.8 2214.0 3225.9 2985.3 True False 2508.2012680097514 2639.199158149747 3158.0433066399037 2372.249202368252 2870.1230040776745 4565.185453151572 2383.7222133750734 2220.4423734525685 3871.1701391769634 2899.1066322590964 0.8651635093722867 0.9103491154077283 1.0893160229084204 0.8182690405284277 0.9900025656666389 1.574686975067972 0.8222264703377208 0.765905727214426 1.3352976037864455 1.0 11.501392682912105 -6.531604591935467 24.997898389390414 1.0915094908574356 0.9285767890762174 0.12018296238609683 0.22850747493783122 499.94106003745725 1432225.3328215973 0.07718827619161457 0.07729874315425621 2.9403254844995663e-07 6.531604591935467 -0.16293270178121821 SYKYS(ph)PETPPR ddPTM_A459_Selumetinib_30min_R1 1 SYKYSPETPPR 11 1 Q99666;O14715;J3KQ37;F8W705;Q99666-2 Q99666 RGPD5;RGPD8 RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 S(0.006)YKYS(0.782)PET(0.211)PPR 113.07 0.0347 4871200.0 1209.1 1388.1 1929.6 1907.3 1629.8 1498.5 1650.9 1398.1 701.35 1344.5 True False 1237.2696775009495 1225.5806066898167 1667.5709185340997 1574.2258594551872 1482.3848777645605 1483.4264505291399 1526.3712838527854 1361.0178463311681 1190.139725422719 1517.0796715390318 0.8155601190317029 0.8078551375264965 1.0991979853255822 1.0376685476631444 0.9771305394005614 0.9778171037149607 1.0061246699748654 0.8971301058634952 0.7844938850280407 1.0 10.567081137363742 -10.5855735321839 24.086112837860036 0.9999999999999937 0.9415252461781075 0.03253556429519655 0.10061154831661015 0.0 0.0 0.1044546468838074 0.025333973069913685 2.5967280414807938e-11 10.5855735321839 -0.05847475382188616 SYLEGS(ph)SDNQLKDSESTPVDDR ddPTM_A459_Selumetinib_30min_R1 2 SYLEGSSDNQLKDSESTPVDDR 22 1 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 S(0.001)YLEGS(0.571)S(0.428)DNQLKDSESTPVDDR;SYLEGS(0.554)S(0.446)DNQLKDSESTPVDDR 131.77 1.2371e-05 26211000.0 1996.66 2131.3 2792.0 2894.7 2377.8 2287.1800000000003 2119.29 2227.5 1306.28 1842.85 True False 2043.1782931759535 1881.7664051855104 2412.861735358213 2389.1949852487437 2162.728409834686 2264.173045793284 1959.4302490498312 2168.41946406028 2216.6617530836097 2079.3977483791036 0.9825817570345148 0.904957412141257 1.1603656574308814 1.148984116728571 1.0400744213176814 1.0888600064890006 0.9423066128532709 1.042811297526204 1.0660114231688016 1.0 11.021950028779163 -5.242073296706536 24.988357642173256 1.0618313285328973 0.9437695750913963 0.35531946171845175 0.06325331644019765 944.9521969026196 1219282.495739384 0.017018024718541965 0.04488621680059203 5.726993672664595e-06 5.242073296706536 -0.11806175344150105 SYLEGS(ph)SDNQLKDSESTPVDDR ddPTM_A459_Selumetinib_30min_R2 1 SYLEGSSDNQLKDSESTPVDDR 22 1 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 S(0.001)Y(0.001)LEGS(0.499)S(0.499)DNQLKDS(0.001)ESTPVDDR 86.189 0.00032631 20145000.0 25103.0 19422.0 23829.0 28113.0 31151.0 18549.0 20274.0 25438.0 14579.0 25812.0 True False 23707.875755270998 20911.60494842703 22295.86808305351 24283.96090236999 27237.532886526595 21103.956378942916 21216.781172168867 25512.0203685124 17495.207371295117 25066.740492369896 0.9457901302519757 0.8342371021390813 0.8894602028468832 0.9687721827958374 1.0866005053516021 0.8419106738415704 0.8464116496768727 1.0177637725287036 0.6979450470084257 1.0 14.61348678971335 -9.982521392115897 11.576580546416027 0.9999971938893375 0.9079949967206884 0.07130120647843852 0.10350644601382257 0.0 0.0 0.09808718151800305 0.02378963587752112 1.0410668263576611e-10 9.982521392115897 -0.0920021971686491 SYLEGSS(ph)DNQLK ddPTM_A459_Selumetinib_30min_R2 2 SYLEGSSDNQLK 12 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 SYLEGS(0.124)S(0.876)DNQLK;SYLEGS(0.225)S(0.775)DNQLK 171.99 3.855e-08 6211300.0 113114.0 78144.0 100566.0 108472.0 116171.0 90598.0 121146.0 130655.0 106765.0 85182.0 True False 106827.57671121882 84137.39352743719 94095.6930479818 93697.92647536284 101576.56039808289 103077.05213324004 126779.5290462449 131035.1844189005 128120.98326334606 82722.57433058486 1.2913956991268545 1.0171031814266114 1.1374850675215504 1.1326766270705877 1.2279182704366973 1.2460571127938116 1.53258684309793 1.584031752871273 1.5488031447296984 1.0 16.33599346264159 -7.034850297897355 2.7025519925062755 1.4637809156474184 1.1496068259604675 0.3158813668655518 0.16977885617113822 0.26810838994894154 3.9076807890437313 0.06698871491856546 0.05252863550062974 9.22889494029921e-08 7.034850297897355 -0.31417408968695093 SYLEGSS(ph)DNQLKDSESTPVDDR ddPTM_A459_Selumetinib_30min_R2 2 SYLEGSSDNQLKDSESTPVDDR 22 1 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 SYLEGS(0.296)S(0.7)DNQLKDS(0.001)ES(0.001)T(0.001)PVDDR;SYLEGS(0.308)S(0.628)DNQLKDS(0.036)ES(0.014)T(0.012)PVDDR 72.801 0.0015112 36435000.0 79149.0 75300.0 79010.0 85221.0 85724.0 57560.0 55164.0 60733.0 46102.0 69243.0 True False 74750.21543855095 81075.26787233842 73926.58261958373 73613.75278557508 74954.58473771645 65488.367522343775 57729.2353053923 60909.722975110635 55323.68819750652 67243.77467508 1.111630270604853 1.205691802164465 1.099381808603025 1.0947296332080498 1.11466950063251 0.973894874860635 0.8585067626607565 0.9058046379672271 0.8227332338915981 1.0 16.037113090919647 -6.878471262587826 2.5310223989919467 0.8888402409637091 1.1302176856063997 0.815639279288185 0.05157290202251237 0.1097847364130396 1.4299209720593173 0.019728231558561155 0.017012917456459196 1.322905242199359e-07 6.878471262587826 0.24137744464269062 SYLLGNSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 SYLLGNSSPR 10 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 SYLLGNS(0.224)S(0.776)PR 123.62 0.0040969 7610200.0 3244.0 3534.6 3389.9 3208.0 3063.9 2970.0 3730.8 3064.3 1637.2 2335.6 True False 3319.5788882748157 3120.7673888090385 2929.570199387824 2647.783021618118 2786.7707859754805 2940.1244965442393 3449.382752315687 2983.0248097508056 2778.2088236430804 2635.3970106705574 1.2596124511161122 1.1841735329338414 1.1116238606654625 1.0046998652944548 1.0574386988723217 1.1156286831319377 1.3088664585826546 1.1319071842582826 1.054189866799684 1.0 11.363804598395989 -5.002371463998881 2.5974472107626987 1.1063058462381463 1.2612805293560911 0.2803878463809183 0.08284342978450132 0.5001864117694577 5.942571958456958 0.023826918791846348 0.1374056045397111 9.94554383765939e-06 5.002371463998881 0.15497468311794482 SYLLGNSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 SYLLGNSSPR 10 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 SYLLGNS(0.084)S(0.916)PR;SYLLGNS(0.066)S(0.934)PR 107.09 0.011501 17573900.0 106078.0 88733.0 104460.0 103702.0 111580.0 75205.0 95267.0 86848.0 81949.0 100758.0 True False 100182.60942387905 95538.53577843554 97739.15732744856 89577.6087040719 97562.32286214369 85563.80610698162 99697.10426797914 87100.71330153965 98341.08984637262 97848.85473927634 1.0238506080712046 0.9763889013622411 0.9988789095986859 0.9154691584562371 0.9970716890054959 0.8744487233393899 1.018888821270597 0.8901556746231144 1.0050305658498289 1.0 16.578267344641326 -4.794176424630896 1.1001048040072017 0.9545972000057208 1.0511423541249847 0.12187254063870756 0.049144347870828387 3.1320555038722837 3.15728753692049 0.014251345427931914 0.35262505793213583 1.6062885934633383e-05 4.794176424630896 0.0965451541192639 SYLPYPAPEGIAVS(ph)PLSLHGK ddPTM_A459_Selumetinib_30min_R1 1 SYLPYPAPEGIAVSPLSLHGK 21 0 H7BYY2;Q6W2J9-4;Q6W2J9-2;Q6W2J9;Q6W2J9-3;H7C231;A1A564 H7BYY2 BCOR BCL-6 corepressor 1 SYLPYPAPEGIAVS(0.949)PLS(0.051)LHGK 75.32600000000002 0.013091 0.0 908.54 999.84 1200.9 1225.3 1330.5 1158.7 1091.0 986.04 414.64 658.3 True False 929.7072142889027 882.778267986995 1037.824376071517 1011.3243567296388 1210.1565099188535 1147.044530015425 1008.7049916308604 959.8870160906845 703.613795892601 742.7992173850093 1.2516265398904087 1.188448031885084 1.3971802228402046 1.3615043379958853 1.6291838784902792 1.544218818718661 1.357977994621427 1.2922563643374891 0.9472462805893108 1.0 9.536828485021994 -8.148803696393875 3.0060187749939278 0.9666052510781388 1.3948172526434457 0.6468500407645478 0.12088273588044683 0.18653992749046247 3.015190536394604 0.11529633752651837 0.03650477222235714 7.098985736972214e-09 8.148803696393875 0.4282120015653069 SYMNPGDQS(ph)PADSNK ddPTM_A459_Selumetinib_30min_R1 2 SYMNPGDQSPADSNK 15 0 Q92754-2;Q92754 Q92754-2 TFAP2C Transcription factor AP-2 gamma 1 SYMNPGDQS(0.981)PADS(0.019)NK;S(0.021)YMNPGDQS(0.979)PADSNK 208.59 1.5838e-06 6125200.0 3102.4700000000003 3133.1000000000004 2902.8199999999997 3288.6000000000004 2519.56 2021.96 2866.1 2787.8199999999997 1778.79 2004.03 True False 3174.751514644257 2766.275195461325 2508.6329880488984 2714.307744667503 2291.666242864447 2001.620918192791 2649.9077694896523 2713.8779574844143 3018.4767123186402 2261.2667714052545 1.4039703562580197 1.2233298744058558 1.109392761513901 1.2003483087405509 1.0134435582053423 0.8851768148297213 1.1718687078406405 1.2001582439553944 1.3348609507240143 1.0 11.142915487755573 -4.671497063535885 1.4958049612244826 1.1118217739587215 1.5807175595349798 0.35844768291143414 0.11942983549838923 1.8075697338470236 3.1043543980362656 0.03651395839710263 1.3629780314473376 2.130604973491127e-05 4.671497063535885 0.46889578557625833 SYMNPGDQS(ph)PADSNK ddPTM_A459_Selumetinib_30min_R2 2 SYMNPGDQSPADSNK 15 0 Q92754-2;Q92754 Q92754-2 TFAP2C Transcription factor AP-2 gamma 1 SYMNPGDQS(1)PADSNK;SYMNPGDQS(0.966)PADS(0.034)NK 200.71 1.8072e-05 15312700.0 64723.0 59191.0 62776.0 64352.0 65285.0 63395.0 65125.0 66029.0 57989.0 61881.0 True False 61125.954766697425 63730.759370937354 58737.060505340894 55587.146586608105 57083.31464469485 72127.08580748746 68153.44154273922 66221.13345831068 69588.42034803702 60094.33474385329 1.0171666768130694 1.0605119374826928 0.977414273004308 0.9249981187668244 0.9498951088818499 1.2002310386648374 1.1341075965519405 1.1019530167123461 1.157986366679179 1.0 15.874941370116646 -6.751844261768663 24.991797418856738 1.12618092097043 0.9862712470550512 0.5583773883210279 0.05889716489817293 148.7329489364191 387394.686770666 0.01993379330094616 0.019689948116991075 1.770743834154432e-07 6.751844261768663 -0.1399096739153789 SYQNS(ph)PSSDDGIRPLPEYSTEK ddPTM_A459_Selumetinib_30min_R2 1 SYQNSPSSDDGIRPLPEYSTEK 22 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 S(0.004)Y(0.003)QNS(0.33)PS(0.33)S(0.33)DDGIRPLPEY(0.001)S(0.001)T(0.001)EK 66.045 0.0036192 14350000.0 18600.0 22729.0 19702.0 23257.0 19699.0 17656.0 13820.0 17203.0 14045.0 15991.0 True False 17566.286461699434 24472.241214746075 18434.394769915667 20089.356479437236 17224.235508705577 20087.95373478982 14462.657383810478 17253.057881890047 16854.392450088486 15529.298280392328 1.1311706520492981 1.5758755336450279 1.1870719743461549 1.2936422571522468 1.1091444827518908 1.293551928238339 0.9313142888157016 1.1110004824670139 1.0853286572110765 1.0 13.92270501994623 -6.565789106200772 0.7432804995566636 1.036243753439389 1.3435631422742025 0.39260111620956617 0.13437503458527542 0.6729994792391298 0.8281797927824849 0.08429931313500362 0.10341536113120649 2.717758694573802e-07 6.565789106200772 0.3073193888348136 SYQNSPS(ph)SDDGIRPLPEYSTEK ddPTM_A459_Selumetinib_30min_R1 2 SYQNSPSSDDGIRPLPEYSTEK 22 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 S(0.001)YQNS(0.091)PS(0.45)S(0.45)DDGIRPLPEY(0.002)S(0.003)T(0.003)EK;S(0.011)Y(0.002)QNS(0.129)PS(0.684)S(0.174)DDGIRPLPEYSTEK 67.227 0.0032503 20083000.0 3006.6200000000003 3545.38 4174.4 4120.82 3507.4 3034.96 3519.5 3082.21 1984.4099999999999 3111.75 True False 3076.6683961358885 3130.2852613975538 3607.539408337866 3401.1961443716905 3190.1562892817647 3004.4310579232015 3254.0212814342954 3000.459778370927 3367.398834428029 3511.173423511777 0.8762507643552084 0.8915211195312394 1.0274455212553149 0.9686779130863635 0.9085726919438403 0.8556772040380318 0.9267617656378005 0.8545461634788609 0.9590522677914473 1.0 11.777737540083676 -6.335188300435531 10.917391645982635 0.9075074341649294 0.943607615818934 0.02174406969582454 0.05655259355791358 2.0340465321616206 295.7286605449399 0.017817543388987285 0.02020333827884578 4.621805867195542e-07 6.335188300435531 0.03610018165400464 SYQNSPSSDDGIRPLPEYS(ph)TEK ddPTM_A459_Selumetinib_30min_R2 1 SYQNSPSSDDGIRPLPEYSTEK 22 1 Q15648 Q15648 MED1 Mediator of RNA polymerase II transcription subunit 1 1 S(0.024)Y(0.018)QNS(0.046)PS(0.117)S(0.117)DDGIRPLPEY(0.174)S(0.252)T(0.252)EK 46.569 0.043144 11421000.0 10706.0 10408.0 13054.0 12401.0 14201.0 10591.0 11477.0 9101.9 10943.0 12845.0 True False 10111.003379513664 11206.26013300529 12214.119852120552 10711.962407081792 12416.943421449207 12049.814114474342 12010.703241244066 9128.385022099343 13131.90577296677 12474.131474681972 0.8105577049620959 0.8983599504101742 0.979155933774696 0.8587341274078477 0.9954154681350893 0.9659842161300896 0.9628488577037608 0.731785218123338 1.0527310698640497 1.0 13.606651749357312 -4.828959741919122 3.358672853584004 0.9344047109421485 0.8005886246022808 0.1778696993975909 0.08528435318132273 0.5062680622210763 9.358139445592812 0.02079546426938883 0.16379353245601974 1.4826555174684907e-05 4.828959741919122 -0.13381608633986775 SYS(ph)AGEASEVSR ddPTM_A459_Selumetinib_30min_R1 2 SYSAGEASEVSR 12 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(0.048)YS(0.952)AGEASEVSR;S(0.119)YS(0.881)AGEASEVSR 173.19 0.00019406 45419000.0 4736.5 4437.6 5260.0 4887.5 4479.4 4421.1 4827.5 5092.3 2866.7 4100.5 True False 4846.851234375358 3918.0437290157306 4545.720891111815 4033.9898747377033 4074.239060902301 4376.627748037625 4463.357788357452 4957.235661878414 4864.580524516013 4626.839117252364 1.0475512788639272 0.8468078594750125 0.9824678956659463 0.8718673315646378 0.8805663991450338 0.945921748547132 0.9646667358099117 1.0714086952783988 1.0513831151762265 1.0 12.175811219576218 -7.560703960604758 3.0253622866752514 1.0458440096133546 0.9236738242287256 0.4253662019505514 0.05735654761246365 0.2216232267167961 4.145265165391292 0.028732731214519133 0.01570607409176524 2.7497679099162418e-08 7.560703960604758 -0.12217018538462898 SYS(ph)AGEASEVSR ddPTM_A459_Selumetinib_30min_R2 2 SYSAGEASEVSR 12 0 Q76N89-2;Q76N89 Q76N89-2 HECW1 E3 ubiquitin-protein ligase HECW1 1 S(0.001)YS(0.999)AGEASEVSR;S(0.041)YS(0.959)AGEASEVSR 167.73 0.00041747 28210000.0 76733.0 53457.0 56702.0 63175.0 62042.0 45304.0 46264.0 55859.0 44162.0 48023.0 True False 72468.48704653665 57556.98000865333 53053.85505246972 54570.456017046345 54247.72929748274 51544.21477123457 48415.36767037688 56021.54044204475 52995.63398937754 46636.45121126141 1.5539022623796368 1.2341629458022507 1.1376048921933983 1.1701245399193043 1.1632044868024483 1.1052344986058473 1.0381443358770384 1.2012393522026201 1.1363564896760532 1.0 15.509170390757133 SYS(ph)AGNASQLEQLSR ddPTM_A459_Selumetinib_30min_R1 2 SYSAGNASQLEQLSR 15 0 Q14678;Q14678-2 Q14678 KANK1 KN motif and ankyrin repeat domain-containing protein 1 1 SYS(1)AGNASQLEQLSR;S(0.112)YS(0.828)AGNAS(0.06)QLEQLSR 226.79 1.1169000000000001e-13 118294000.0 1867.5500000000002 2208.97 2495.8999999999996 2539.0 2504.83 2051.2 2286.51 2026.1399999999999 1114.88 1400.6 True False 1911.0602813802802 1950.342765477707 2156.970488997337 2095.6113129327946 2278.2685687636535 2030.566790340586 2114.0367098202382 1972.4001853697398 1891.869932386512 1580.3806529993067 1.2092404938983512 1.2340968372247991 1.3648423782610575 1.3260168105422345 1.4415948236520542 1.284859306830224 1.337675645299845 1.248053867039212 1.197097628850397 1.0 10.626056374743305 -8.625928447846897 1.2374962458084302 1.0013285696385634 1.3174003408750223 0.6966241048473851 0.06273662125526495 0.3464397538478099 1.12288361419447 0.06359262470868014 0.01954232752815488 2.366309526511103e-09 8.625928447846897 0.3160717712364589 SYS(ph)AGNASQLEQLSR ddPTM_A459_Selumetinib_30min_R2 1 SYSAGNASQLEQLSR 15 0 Q14678;Q14678-2 Q14678 KANK1 KN motif and ankyrin repeat domain-containing protein 1 1 S(0.011)YS(0.989)AGNASQLEQLSR 125.61 0.0012149 40837000.0 13747.0 19352.0 18974.0 19388.0 20277.0 16432.0 18019.0 14432.0 16240.0 21024.0 True False 12982.996773601193 20836.23617351251 17753.23349732919 16747.320953834496 17729.621981320026 18695.35884515554 18856.91920397114 14473.994730653776 19488.45378351277 20416.982493087886 0.6358920461432805 1.020534556493182 0.8695326796376251 0.8202642559694733 0.8683762151102564 0.915676880826283 0.9235899188508929 0.7089193878455794 0.954521746301665 1.0 14.317482039891463 -14.522878738775429 0.3650882907843679 2.7727990989864315 0.8574700260445156 0.141850908907183 0.10757901974067513 1057.017005138057 8.294779478569028 1475.2507648927483 0.07293275700792079 3.000000044934318e-15 14.522878738775429 -1.915329072941916 SYS(ph)CSSPK ddPTM_A459_Selumetinib_30min_R1 1 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(0.007)YS(0.897)CS(0.094)S(0.001)PK 133.75 0.002981 21942000.0 4845.9 6427.4 5524.4 6431.1 5202.0 5660.8 5366.8 5223.7 3157.4 3992.0 True False 4958.800041520012 5674.877019982802 4774.216823357059 5308.029111698343 4731.480018487691 5603.857491595161 4961.977955164529 5085.150507031062 5357.877192628065 4504.412085372863 1.1008761959463433 1.2598485468083127 1.0598978807601398 1.178406640221719 1.0504101154182106 1.2440818880209734 1.1015817072504346 1.128926574800744 1.1894731412400414 1.0 12.137123102828129 -11.037188927514595 4.224327508459463 0.9987039848782393 1.145990041902549 0.2924769757263994 0.06809793604741163 0.0007697952680077106 8.850660602232761e-05 0.061064845417103907 0.014682409383427427 9.179331887775994e-12 11.037188927514595 0.14728605702430975 SYS(ph)CSSPK ddPTM_A459_Selumetinib_30min_R2 2 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(0.128)YS(0.774)CS(0.098)SPK;S(0.005)YS(0.496)CS(0.496)S(0.002)PK 111.06 0.011761 12960800.0 84011.0 59774.0 66799.0 74336.0 72004.0 66770.0 56033.0 73326.0 49729.0 68203.0 True False 79342.00494267906 64358.47359629689 62501.22506525207 64211.30856324746 62958.213796072676 75966.96142228795 58638.645527283086 73539.36652022727 59676.189544353874 66233.80217732467 1.1979080519982894 0.9716862309065838 0.9436454349686955 0.9694643286722014 0.9505450650034794 1.1469515402257164 0.8853280892782295 1.1102996370847584 0.9009929610349953 1.0 16.015280058630978 -4.758565811824693 24.861834473844333 0.9888429266843396 1.1979083557142285 0.3912385453064934 0.07904866435325603 74.0725121439709 640741.7570012828 0.01826129017373565 0.12367642313564706 1.7435491246728386e-05 4.758565811824693 0.2090654290298889 SYS(ph)LSELSVLQAK ddPTM_A459_Selumetinib_30min_R1 1 SYSLSELSVLQAK 13 0 Q9P0V3-2;Q9P0V3 Q9P0V3-2 SH3BP4 SH3 domain-binding protein 4 1 S(0.003)YS(0.944)LS(0.053)ELSVLQAK 297.91 7.8198e-74 66696000.0 4539.1 4175.0 4551.7 4359.9 3882.5 3856.8 3864.4 3496.7 1989.5 2985.3 True False 4644.8521984488925 3686.189059095158 3933.6041406984127 3598.5253104591156 3531.3285605110477 3818.0040936942187 3572.9051967537116 3403.9561571176587 3376.0361926691367 3368.4923342844713 1.3789113162507889 1.0943142193251187 1.1677640173505044 1.0682895946751523 1.0483409816816953 1.13344597962555 1.060683784371046 1.0105280996106885 1.0022395355654765 1.0 11.71788730083384 -1.5228787452803383 0.7545875900872172 1.0481419586366236 56.81268641751112 0.7818450238474073 0.05034641063609811 181.99217483812532 0.7705964508774664 0.01896345400975803 17261.28244211008 0.02999999999999995 1.5228787452803383 55.7645444588745 SYS(ph)PAHNR ddPTM_A459_Selumetinib_30min_R1 2 SYSPAHNR 8 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 S(0.042)YS(0.958)PAHNR;S(0.002)YS(0.998)PAHNR 87.806 0.029706 1014800.0 1341.69 1297.68 1376.17 1591.3400000000001 1339.3200000000002 1438.12 1377.94 1479.69 1081.75 1128.5 True False 1372.94876652572 1145.7470223249354 1189.2936727607137 1313.4423421514266 1218.178742476151 1423.6538185084853 1274.0008764141417 1440.4438144894982 1835.6507421059753 1273.353967520861 1.0782145432811299 0.8997867455155708 0.9339851314683478 1.0314825065559854 0.9566693735975609 1.1180346194548312 1.0005080354008242 1.1312202665013487 1.441587169732443 1.0 10.314417800682705 -7.929946466684479 4.193936000760222 1.2402795524778305 1.0006081696103342 0.3629160423031369 0.11691333290837115 0.1926376258594457 6.565814140828018 0.06724941370396254 0.02951276463241568 1.175042387629656e-08 7.929946466684479 -0.23967138286749634 SYS(ph)PDGK ddPTM_A459_Selumetinib_30min_R1 5 SYSPDGK 7 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 SYS(1)PDGK;S(0.223)YS(0.777)PDGK;S(0.124)YS(0.876)PDGK;S(0.131)YS(0.868)PDGK;S(0.367)YS(0.633)PDGK 140.11 0.003069 1362755000.0 42390.399999999994 63069.2 45819.700000000004 39480.0 43343.5 50064.5 44770.3 51120.7 39429.399999999994 45406.3 True False 43378.01384264016 55685.02874392436 39597.636409596256 32585.55913138506 39423.08807791643 49560.896584929 41393.240226224705 49764.81297256402 66908.81199056466 51234.64089981612 0.846654003635182 1.0868628678946048 0.7728684287458014 0.636006392532401 0.7694615866441628 0.9673317840138678 0.8079151039072329 0.9713118331379311 1.305929168536532 1.0 15.644831958437411 -8.022123746686749 5.0484995403409645 1.1536211893186894 0.8440164280118958 0.4662484315404376 0.13288482546608948 0.16930124795539508 11.929807573525801 0.09162142066692769 0.03619039857522723 9.503339695014013e-09 8.022123746686749 -0.3096047613067936 SYS(ph)PDGK ddPTM_A459_Selumetinib_30min_R2 4 SYSPDGK 7 0 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 S(0.009)YS(0.991)PDGK;SYS(1)PDGK;S(0.3)YS(0.7)PDGK;S(0.001)YS(0.999)PDGK 119.75 0.0099223 1995542000.0 569621.0 384095.0 408064.0 434205.0 399829.0 422969.0 778070.0 1152900.0 558081.0 806030.0 True False 537963.745193532 413553.851439918 381809.6065064901 375065.52995459584 349598.906503388 481229.14041970565 814251.7967164562 1156254.7481271306 669712.7940859981 782757.8195825526 0.687267161994536 0.5283292496017065 0.4877748863755975 0.47915909694088976 0.44662461077658766 0.6147867557252213 1.0402346375162363 1.4771551547626378 0.8555810971561525 1.0 19.578206490086444 -7.26322508476374 3.5919278170228353 1.1460808580388935 0.5232352961121879 0.7427049074960952 0.1596630831529602 0.10715354429561844 3.0318030870002857 0.06574918983203044 0.04570177421887508 5.454750807272188e-08 7.26322508476374 -0.6228455619267056 SYS(ph)PDGKESPSDK ddPTM_A459_Selumetinib_30min_R1 2 SYSPDGKESPSDK 13 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 S(0.027)YS(0.971)PDGKES(0.002)PSDK;S(0.155)YS(0.521)PDGKES(0.31)PS(0.014)DK 145.86 0.0029238000000000003 7255200.0 1939.0300000000002 1993.14 4459.71 4200.719999999999 2838.5299999999997 2593.94 2208.3 2593.64 1600.0 2206.07 True False 1984.2056263044133 1759.7822422143524 3854.1058774335156 3467.1431092804455 2581.785462683176 2567.8473187090804 2041.7261530874698 2524.848241869945 2715.083140623584 2489.2405734415115 0.7971128413519069 0.7069554710741988 1.5483059044409688 1.3928517581918287 1.0371779611135439 1.0315786051803304 0.8202205021367909 1.0143046312230095 1.0907274972100558 1.0 11.281489951437024 -6.511879162779657 23.019405929191926 0.9874318585873721 1.126310524715691 0.0512348487161165 0.23975253313268383 634.8326334015032 1328554.3616183507 0.0848906653919718 0.0906250719808704 3.0769528207927955e-07 6.511879162779657 0.1388786661283189 SYS(ph)PDGKESPSDK ddPTM_A459_Selumetinib_30min_R2 4 SYSPDGKESPSDK 13 1 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 S(0.229)YS(0.771)PDGKESPSDK;S(0.113)YS(0.887)PDGKESPSDK;S(0.202)YS(0.798)PDGKESPSDK;S(0.012)YS(0.945)PDGKES(0.043)PSDK 167.92 0.0013934000000000002 60227000.0 99246.0 111252.0 104285.0 101535.0 93481.0 63578.0 63179.0 62931.0 41866.3 90915.0 True False 93730.30463321623 119784.6706684384 97575.41663692314 87705.75784235523 81737.08104925667 72335.2923963789 66116.94868681354 63114.11879121211 50240.729842160166 88290.04772446172 1.0616180084728535 1.3567177021159402 1.1051689193943974 0.9933821546463543 0.9257791014491717 0.8192915765786547 0.7488607197625868 0.7148497528077069 0.5690418244981923 1.0 16.429963202386105 -6.213989325498743 1.0069319907338043 0.7346628910359128 1.2191056185955664 0.6684135733414558 0.12359365082506302 0.2948734017957105 0.6269216892553435 0.05376648219756196 0.08825572784972432 6.109570414020527e-07 6.213989325498743 0.4844427275596537 SYS(ph)PDHR ddPTM_A459_Selumetinib_30min_R2 1 SYSPDHR 7 0 A0A024RAC6;Q14241 A0A024RAC6 TCEB3 Transcription elongation factor B polypeptide 3 1 S(0.045)YS(0.955)PDHR 90.601 0.029436 22240000.0 19730.0 15673.0 15514.0 15406.0 18903.0 18717.0 22821.0 39463.0 22286.0 45886.0 True False 18633.48558544783 16875.068703362016 14515.846130366032 13307.676223167644 16528.23614503587 21295.09685399077 23882.221718953606 39577.83079654868 26743.82272286735 44561.151953854205 0.4181553835220405 0.3786946244306516 0.3257511418330944 0.2986385144833903 0.37091133016830147 0.4778847924767103 0.535942646718045 0.8881689332792371 0.6001600396363679 1.0 15.443498907932767 -7.722488078475658 0.769745551160818 0.929696952967191 0.3383518904207981 0.8051664059324457 0.09995658639100677 0.2581928784735396 0.2890926120210191 0.08758257536896052 0.041244466625953075 1.8945755203551197e-08 7.722488078475658 -0.591345062546393 down SYS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 SYSPER 6 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-5;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;F8VWU8 F8WF16 PPHLN1 Periphilin-1 1 S(0.002)YS(0.998)PER 98.629 0.034365 18727000.0 55721.0 52493.0 58357.0 59377.0 68390.0 38593.0 52122.0 52978.0 48664.0 57855.0 True False 52624.24988883622 56519.04430840183 54602.37415429745 51289.75016896177 59798.23678564268 43908.835437627095 54545.776277783625 53132.15720901998 58398.15978576759 56184.57582465748 0.9366316131506904 1.0059530303261197 0.971839216597491 0.9128795477432876 1.0643176691813572 0.7815104909692495 0.9708318604738021 0.945671590986758 1.0393984279247446 1.0 15.777886505806412 -8.25293757278481 23.848143603365763 1.0196992151745212 0.9492078917435255 0.1442253277577049 0.06916574228029959 578.4509628093737 1622614.3297115006 0.046987722580570865 0.017102206058795262 5.585504772325168e-09 8.25293757278481 -0.07049132343099573 SYS(ph)PSFQR ddPTM_A459_Selumetinib_30min_R1 1 SYSPSFQR 8 0 Q9P227;Q9P227-2 Q9P227 ARHGAP23 Rho GTPase-activating protein 23 1 SYS(0.832)PS(0.168)FQR 98.044 0.019779 9423600.0 2101.9 2433.4 2427.7 2621.0 2856.6 1990.9 2453.3 1911.9 1200.9 1794.2 True False 2150.87018041456 2148.4963967430317 2098.031674401551 2163.291552263431 2598.221034373694 1970.8733535925676 2268.2456058368375 1861.190201273557 2037.8395897342868 2024.503046987975 1.0624188408185367 1.0612463142199426 1.036319346381311 1.0685543573184262 1.283387070342664 0.9735096998371048 1.1203962420365328 0.9193318844555989 1.0065875636819386 1.0 10.98335209901315 -7.755696593560212 24.999074246639147 0.9722197880267899 1.0861735584838845 0.29683403867150815 0.07841496983604612 168.80104567731007 734821.1580240602 0.03794035623972125 0.021135888955476384 1.7551062244458324e-08 7.755696593560212 0.11395377045709465 SYS(ph)PSFQR ddPTM_A459_Selumetinib_30min_R2 1 SYSPSFQR 8 0 Q9P227;Q9P227-2 Q9P227 ARHGAP23 Rho GTPase-activating protein 23 1 SYS(0.864)PS(0.136)FQR 117.7 0.0087321 6705800.0 25150.0 20952.0 27880.0 26121.0 26306.0 23497.0 19716.0 20747.0 20286.0 25566.0 True False 23752.263683426918 22558.951028701656 26086.23115344881 22563.274738761666 23001.205101376177 26733.49846547102 20632.833066512827 20807.370335149266 24343.766838198288 24827.843151554654 0.9566784975415641 0.9086150130318136 1.0506845477560285 0.9087891606625045 0.9264278399445223 1.0767547669076136 0.8310360646539228 0.8380659652204369 0.9805026836039902 1.0 14.599671316468509 -7.286092603560204 24.99877373338673 0.8989066928252697 0.9671984838275587 0.12446259516305824 0.07264632173497568 1455.1573965849827 1475546.845466353 0.02979228600114553 0.02009674037670673 5.174964756657254e-08 7.286092603560204 0.06829179100228899 SYS(ph)PYDYQPCLAGPNQDFHSK ddPTM_A459_Selumetinib_30min_R2 1 SYSPYDYQPCLAGPNQDFHSK 21 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7 E9PGF5 TNS1 Tensin-1 1 S(0.149)Y(0.001)S(0.818)PY(0.025)DY(0.007)QPCLAGPNQDFHSK 114.01 5.451399999999999e-05 8601800.0 21195.0 22381.0 29453.0 27038.0 33490.0 17189.0 20390.0 23017.0 17395.0 17352.0 True False 20017.066750307495 24097.550733742446 27558.026046001734 23355.377756848415 29282.68679560131 19556.628723793732 21338.175402018514 23083.97565933054 20874.486056909154 16851.002674089646 1.187885797507233 1.4300366096787345 1.635393844449112 1.385993356511657 1.7377415078466996 1.1605617245473645 1.2662852065668717 1.369887365505247 1.2387681884951616 1.0 14.040546817241406 -6.797078549170877 24.99990839318594 1.2339174102093022 1.4768103441800453 0.3979688910044562 0.16334150215043217 203.98749193785343 143090.29084801453 0.05704791635566268 0.050313189022259196 1.5955905328206977e-07 6.797078549170877 0.24289293397074307 SYS(ph)SER ddPTM_A459_Selumetinib_30min_R2 1 SYSSER 6 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 1 SYS(0.772)S(0.227)ER 108.09 0.02569 36410000.0 73699.0 67165.0 61702.0 70811.0 69761.0 76131.0 136630.0 249180.0 94071.0 172620.0 True False 69603.10462047243 72316.33953048631 57732.16049605806 61166.4196442116 60996.99950874714 86617.35420159066 142983.56572720892 249905.07254603016 112887.82856335175 167636.0120793771 0.41520377248961726 0.43138904721882726 0.3443899659741451 0.3648763704498576 0.36386572760908037 0.5166989665715538 0.8529406298421425 1.490760066683631 0.673410367874287 1.0 17.354972580916936 -7.302847157306988 2.9282910697803106 1.0748766407227903 0.3901762724211937 0.7098885218894597 0.19028991059429629 0.1315658988560114 2.254088105354632 0.08157692282052786 0.05372592189782007 4.9791228606476224e-08 7.302847157306988 -0.6847003683015966 down SYS(ph)SPDITQAIQEEEK ddPTM_A459_Selumetinib_30min_R1 2 SYSSPDITQAIQEEEK 16 0 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 S(0.001)YS(0.499)S(0.499)PDITQAIQEEEK;SYS(0.92)S(0.08)PDITQAIQEEEK 284.15 5.866499999999998e-63 127706900.0 5444.79 5227.92 6487.97 6700.82 4756.96 5007.7300000000005 5096.54 4730.469999999999 2829.54 3475.71 True False 5571.643013282934 4615.832696005928 5606.939309868201 5530.647576969803 4326.693807909503 4957.356782855044 4712.103884552108 4605.002568867895 4801.522718575035 3921.8512347823953 1.4206665882348486 1.1769525205516975 1.4296664952869644 1.4102135052750597 1.103227417077071 1.264034887118839 1.2014999046269434 1.174191037137441 1.2243000642122643 1.0 11.937319096349155 -13.00146694761729 0.05139734160423586 5.050040736251409e-13 1.8520004994126749 0.5210694324166971 0.09400223035740925 328.6705411475404 1.6465355042066716 52.5361318367491 16.04684870222917 9.966279265375014e-14 13.00146694761729 1.85200049941217 SYS(ph)SPDITQAIQEEEK ddPTM_A459_Selumetinib_30min_R2 4 SYSSPDITQAIQEEEK 16 0 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 S(0.039)YS(0.767)S(0.194)PDITQAIQEEEK;SYS(0.5)S(0.5)PDITQAIQEEEK;S(0.015)YS(0.897)S(0.088)PDITQAIQEEEK;S(0.001)YS(0.887)S(0.111)PDITQAIQEEEK 297.55 7.152399999999997e-88 109520000.0 301230.0 265978.0 281732.0 304457.0 302766.0 223382.0 246688.0 244260.0 190446.0 270570.0 True False 284488.8425192319 286377.6573459334 263605.66984660836 262989.43138238025 264729.8283176177 254150.8428401005 258159.48080299833 244970.75616058012 228540.52150584222 262757.94107471383 1.0827031196683756 1.0898915411447199 1.003226272699608 1.0008810021372507 1.0075045771588809 0.9672432422045583 0.9824992529135096 0.932305814083556 0.8697758879182949 1.0 18.003374840435825 -5.354624129652337 0.4804419589953895 0.9360269557937515 1.1523530784124425 0.6627470104755819 0.03556198397595717 1.7090906633880003 0.4536613582010979 0.026353503737785954 0.19757958665841296 4.419527802815998e-06 5.354624129652337 0.216326122618691 SYS(ph)SPDITQAIQEEEKR ddPTM_A459_Selumetinib_30min_R1 4 SYSSPDITQAIQEEEKR 17 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 S(0.008)YS(0.964)S(0.028)PDITQAIQEEEKR;S(0.007)YS(0.938)S(0.055)PDITQAIQEEEKR;S(0.013)YS(0.984)S(0.003)PDITQAIQEEEKR;S(0.004)YS(0.785)S(0.211)PDITQAIQEEEKR 249.26 9.195299999999996e-31 1434230000.0 13607.300000000001 15574.2 16550.0 16863.8 15189.9 14164.8 13985.300000000001 14055.599999999999 8256.2 12334.9 True False 13924.3236148033 13750.765423750852 14302.6009026427 13918.853902731811 13815.976226994655 14022.314972609376 12930.37756137037 13682.799828976737 14010.168391010262 13918.204567100642 1.0004396434664513 0.9879697742232086 1.0276182415403408 1.000046653692151 0.9926550626833269 1.0074801606059756 0.9290262619026837 0.9830865585435965 1.006607448788833 1.0 13.76468549668412 SYS(ph)SPDITQAIQEEEKR ddPTM_A459_Selumetinib_30min_R2 6 SYSSPDITQAIQEEEKR 17 1 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 S(0.101)Y(0.066)S(0.721)S(0.113)PDITQAIQEEEKR;S(0.045)Y(0.001)S(0.909)S(0.045)PDITQAIQEEEKR;S(0.011)YS(0.921)S(0.067)PDITQAIQEEEKR;S(0.002)YS(0.499)S(0.499)PDITQAIQEEEKR;S(0.31)YS(0.682)S(0.008)PDITQAIQEEEKR;S(0.049)YS(0.948)S(0.003)PDITQAIQEEEKR 171.87 1.1512e-06 559039000.0 393274.0 319749.0 368328.0 374292.0 355602.0 294820.0 300478.0 322552.0 275380.0 316576.0 True False 371417.4054805583 344272.7201449175 344630.177485205 323312.7839102867 310928.0976377852 335428.7788905037 314450.8223858614 323490.5729186422 330463.6947600836 307435.6283167713 1.2081143864622688 1.1198205036606574 1.1209832099554502 1.051643837379694 1.0113600018974227 1.091053697084481 1.0228184160290683 1.0522221340765632 1.07490370120533 1.0 18.229924841213773 -4.5836849987128225 0.7757483448793455 1.0428358319606055 1.3435779142255233 0.759116596551395 0.02926821784736214 1.6727134487456192 0.6243644807001685 0.011092034446783583 0.46817563852242705 2.608044523867204e-05 4.5836849987128225 0.30074208226491783 SYSAGNAS(ph)QLEQLSR ddPTM_A459_Selumetinib_30min_R2 1 SYSAGNASQLEQLSR 15 0 Q14678;Q14678-2 Q14678 KANK1 KN motif and ankyrin repeat domain-containing protein 1 1 SYS(0.032)AGNAS(0.968)QLEQLSR 120.32 0.0018057 43513000.0 34565.0 35974.0 38716.0 48505.0 51187.0 31346.0 37626.0 37461.0 32640.0 43169.0 True False 32644.015674658127 38733.090125358576 36225.054710793556 41898.535324207915 44756.431442413996 35663.6269693431 39375.68355450457 37570.00530799759 39168.9120377991 41922.59880346798 0.7786734746023832 0.923919108806643 0.8640937285547501 0.999426002205329 1.0675967788216314 0.8507017214398666 0.9392472002772708 0.8961754848291912 0.9343149794081685 1.0 15.355440532604755 -3.9535332391471134 1.1887754622351123 0.9451286831441476 3.9109562794260184e-09 0.3909031473504814 0.06207341697376373 10.370093931236235 2.888301524595752 0.019127720201179678 19.462448282166154 0.00011129272105844372 3.9535332391471134 -0.9451286792331913 SYSCS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 2 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 SYS(0.001)CS(0.765)S(0.234)PK;SYS(0.002)CS(0.959)S(0.04)PK 107.21 0.013401 18637600.0 5882.5 7474.6 8190.6 9131.2 6744.0 7925.0 6461.0 6460.5 3903.6 4807.9 True False 6019.550804647535 6599.470357152736 7078.361507745332 7536.607333852667 6134.006390749908 7845.28169532428 5973.6415682190545 6289.146553338468 6624.124092336388 5425.040797911874 1.1095862738883902 1.2164830833517246 1.3047572859672927 1.3892259274351533 1.1306839191165012 1.446123999352036 1.1011238054685857 1.1592809690498904 1.2210275164909445 1.0 12.405418271753549 -8.88261067625666 0.6281396745292696 0.9987041166936622 1.256730999779696 0.2963958947795001 0.10996821489553972 1.704323993446157 1.2939277070652373 0.125336085121254 0.04526097798019874 1.3103560667085432e-09 8.88261067625666 0.25802688308603383 SYSCS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 S(0.037)YS(0.241)CS(0.691)S(0.032)PK 120.27 0.007467100000000002 12517000.0 32437.0 23835.0 27759.0 28386.0 23236.0 26238.0 24346.0 25623.0 21819.0 30233.0 True False 30634.281395599173 25663.067858395552 25973.016161714004 24519.777831418727 20316.8859475244 29852.04633515038 25478.137240683776 25697.558687884008 26183.409673797112 29360.094735232415 1.0433985881809067 0.8740798723513521 0.8846366606081185 0.8351396019848241 0.6919897953579804 1.0167557906183327 0.867781165913942 0.8752546243335746 0.8918026290418182 1.0 14.84156900283376 -9.57196688338982 14.049938786462755 1.000007330040912 0.8820045204806087 0.12028012862685467 0.09106122245471873 0.0 0.0 0.08776647421246513 0.021286496680355437 2.6793726294086877e-10 9.57196688338982 -0.11800280956030329 SYSCSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 SYSCS(0.003)S(0.997)PK 95.523 0.022239 0.0 4087.4 4655.7 5833.0 4502.1 4564.6 4222.9 3267.5 4202.2 4316.1 4391.9 True False 4182.628467304092 4110.60847962379 5040.9106383755225 3715.892749883706 4151.732735945584 4180.421460086419 3021.0298443206593 4090.744005330688 7324.106464528402 4955.643145728726 0.8440132479896385 0.8294803234907516 1.0172061405834454 0.7498305750861899 0.8377787935606232 0.8435678956604308 0.6096140814587281 0.8254718681381455 1.4779325809286847 1.0 12.274856587874362 -8.236875398593382 23.68165067925512 1.2389661654509567 0.8186121473912489 0.57985381426842 0.14277990218595982 225.47896141389216 217380.77298705038 0.09253486049611427 0.034928230650317686 5.7959496146489574e-09 8.236875398593382 -0.42035401805970785 SYSCSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 SYSCSSPK 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 SYS(0.078)CS(0.006)S(0.915)PK;SYSCS(0.118)S(0.882)PK 108.43 0.012878 5069800.0 67633.0 41663.0 47248.0 54318.0 53133.0 47144.0 80469.0 111776.0 43105.0 74430.0 True False 63874.22861635043 44858.41813234043 44208.11511973281 46919.79469622355 46457.957524953235 53637.65806937761 84210.96794629846 112101.24965448714 51727.20445432995 72281.0125076357 0.8836930529937279 0.6206113691005867 0.6116144971691244 0.6491302911849358 0.6427408238096478 0.7420712052658556 1.1650496447791525 1.5509086794079545 0.71564028587543 1.0 16.141329095070084 -7.220676569069996 4.771753202548545 1.1554143249645437 0.6761806789796193 0.4884345564602467 0.20679581915981501 0.15407197293160962 8.467192851545587 0.07964252787512774 0.05933681694780208 6.016216146928554e-08 7.220676569069996 -0.47923364598492435 SYSEDDIHR ddPTM_A459_Selumetinib_30min_R1 2 SYSEDDIHR 9 0 Q9Y5A9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q9Y5A9-2;Q7Z739;Q9BYJ9 Q9Y5A9 YTHDF2;YTHDF3;YTHDF1 YTH domain-containing family protein 2;YTH domain-containing family protein 3;YTH domain-containing family protein 1 0 ; 228.05 0.00015599 16967500.0 14488.5 13435.8 13142.6 13905.3 14955.3 11903.3 12975.8 12542.6 6987.3 9874.8 False True 14826.053860286574 11862.730289866042 11357.907107134257 11477.00038980873 13602.595755572667 11783.563609331663 11997.024959123484 12209.92950389336 11856.937767799482 11142.326768697381 1.33060662894379 1.064654675466216 1.0193478743634152 1.0300362418064746 1.2208038803696752 1.0575496351835358 1.0767073348474434 1.09581506245134 1.0641348089978555 1.0 13.443762910894096 -4.760087947116692 24.998840789530952 1.0746065036577948 1.3306069391432318 0.6492970445066601 0.057387874430364846 22.060449858345386 407923.36029467743 0.014385863121094347 0.08751865132244425 1.7374489497715192e-05 4.760087947116692 0.25600043548543705 SYSEDDIHR ddPTM_A459_Selumetinib_30min_R2 2 SYSEDDIHR 9 0 Q9Y5A9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q9Y5A9-2;Q7Z739;Q9BYJ9 Q9Y5A9 YTHDF2;YTHDF3;YTHDF1 YTH domain-containing family protein 2;YTH domain-containing family protein 3;YTH domain-containing family protein 1 0 ; 196.79 0.0026041000000000003 15630100.0 161621.0 157993.0 180450.0 193834.0 193082.0 155061.0 145323.0 154909.0 144016.0 164694.0 False True 152638.7518401248 170110.555072435 168840.04345910493 167433.47481769923 168825.31298501897 176419.245246389 152080.80745206142 155359.75954343463 172823.2241432494 159938.85629359842 0.9543569047406912 1.0635974210054653 1.0556536877390612 1.0468592729608057 1.055561587079926 1.1030418081928615 0.9508684191969458 0.9713697042965095 1.0805580841843663 1.0 17.287160950916473 -9.889567322523932 6.945498093395172 0.9999999927906977 1.0321338990786644 0.032589225616059814 0.05101694481934413 0.0 0.0 0.050271900981803785 0.012192726926386425 1.2895336442631489e-10 9.889567322523932 0.03213390628796664 SYSEHDDER ddPTM_A459_Selumetinib_30min_R2 2 SYSEHDDER 9 0 Q9UBU9-2;Q9UBU9;E9PQA4 Q9UBU9-2 NXF1 Nuclear RNA export factor 1 0 ; 152.11 9.5158e-05 0.0 29145.0 19310.3 27070.0 30840.0 35266.0 31589.0 45940.0 69389.0 47942.0 52366.0 False True 27525.237576679017 20791.33791759916 25328.345671587496 26639.538798032605 30835.569797959863 35940.09801360872 48076.301028383044 69590.91050203265 57531.73961140205 50854.05751679225 0.5412594180432909 0.40884324541328415 0.49805948450079834 0.5238429360181556 0.606354169237682 0.7067301955550179 0.9453778788940886 1.3684436188607645 1.1313107040161898 1.0 15.634075267217671 -7.218305714200251 1.6387719663994649 1.1893021569027384 0.5019328702493618 0.8867786265756084 0.10207894180279246 0.1113823967215016 0.5857692524088969 0.05476273180582858 0.03449961005038236 6.049149053045667e-08 7.218305714200251 -0.6873692866533766 SYSLS(ph)ELSVLQAK ddPTM_A459_Selumetinib_30min_R1 1 SYSLSELSVLQAK 13 0 Q9P0V3-2;Q9P0V3 Q9P0V3-2 SH3BP4 SH3 domain-binding protein 4 1 S(0.103)YS(0.192)LS(0.705)ELSVLQAK 212.1 4.9679e-06 67457000.0 2263.7 2309.5 2688.6 2401.5 1869.7 2116.9 2241.6 2167.8 1239.2 1812.5 True False 2316.439805606566 2039.102666342579 2323.5028874226673 1982.123106738127 1700.5859651223448 2095.605907991414 2072.5143072774863 2110.3029019932096 2102.831892412966 2045.1520302450701 1.1326491973943804 0.9970420957400579 1.1361027703863378 0.9691813016466114 0.831520561783646 1.0246699888322228 1.013379091934372 1.0318562487211929 1.0282032148783502 1.0 10.997992377280529 -5.777981287119818 24.979207741012917 0.9832440308091603 1.0794424353953938 0.33684649683886714 0.0658319247490719 294.2847792861883 444385.6609045846 0.019499006473088817 0.02901706541652999 1.6673190524449201e-06 5.777981287119818 0.09619840458623341 SYSPS(ph)FQR ddPTM_A459_Selumetinib_30min_R2 1 SYSPSFQR 8 0 Q9P227;Q9P227-2 Q9P227 ARHGAP23 Rho GTPase-activating protein 23 1 S(0.007)YS(0.24)PS(0.753)FQR 122.28 0.0064803 7254200.0 28421.0 26612.0 36449.0 33423.0 32415.0 25761.0 24307.0 30343.0 21495.0 26505.0 True False 26841.47459827739 28653.054828933175 34103.91102267058 28870.72974210908 28342.737906223243 29309.34391492527 25437.323663406765 30431.293106445934 25794.600620480735 25739.731781739654 1.0428031972469634 1.1131838929751512 1.3249520745536543 1.1216406599306767 1.1011279428455514 1.1386810151502036 0.9882513104294496 1.1822692390304774 1.0021316787294576 1.0 14.651709399729269 -6.835035663248863 1.4063214897223024 1.057731931250737 1.1566347540923114 0.20961385789426423 0.08657323504570458 0.7290523226739206 2.9990585731624164 0.04234987623946925 0.03591251824912523 1.4620571088108652e-07 6.835035663248863 0.09890282284157448 SYSPY(ph)DMLESIR ddPTM_A459_Selumetinib_30min_R1 1 SYSPYDMLESIR 12 0 P07355;H0YN42;P07355-2;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 SYS(0.013)PY(0.987)DMLESIR 169.93 0.0045753 2719200.0 467.91 669.15 445.41 646.38 608.27 476.96 484.87 498.25 348.7 561.93 True False 478.81139260563145 590.8056069206043 384.9257684619988 533.5018670553366 553.2520858987906 472.1622154450303 448.29586552892323 485.03479145590757 591.7184319596521 634.0591891617167 0.7551525169734755 0.9317830527804548 0.6070817599393288 0.841407042394061 0.8725558991270824 0.7446658348556878 0.7070252638741986 0.7649676871605112 0.9332227055047606 1.0 9.308473711408034 -8.39132391618305 3.5562755111421325 0.9964195328557449 0.779263750830509 0.44528040786727463 0.08549393698113504 0.21040674114524233 4.577975844694017 0.08093205016540607 0.021528601093281852 4.061402986342122e-09 8.39132391618305 -0.2171557820252359 SYSPYDMLESIRK ddPTM_A459_Selumetinib_30min_R1 2 SYSPYDMLESIRK 13 1 P07355;H0YN42;P07355-2;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ; 135.02 0.0015823 25074000.0 4911.0 4981.7 8339.5 8979.7 7237.0 5905.8 5451.3 5525.1 3585.5 4196.9 False True 5025.416744857463 4398.440248070504 7207.041705594486 7411.563964845459 6582.414627796127 5846.39301403736 5040.104052133191 5378.556399945886 6084.33162544116 4735.612996267878 1.0611966705932216 0.9288006117765327 1.5218814779151788 1.5650696057060596 1.3899815362834143 1.2345588667496445 1.0642981291134392 1.1357677251466094 1.2848033887558385 1.0 12.209335470532166 -7.0271925629681755 6.992844245868372 1.1342931155144997 1.30218458031994 0.15017347163052208 0.1918811414289279 0.4539231152729743 84.70194728716736 0.08105847532712053 0.06479185679521651 9.39306736543655e-08 7.0271925629681755 0.16789146480544037 SYSS(ph)PDITQAIQEEEK ddPTM_A459_Selumetinib_30min_R1 1 SYSSPDITQAIQEEEK 16 0 P40818;P40818-2 P40818 USP8 Ubiquitin carboxyl-terminal hydrolase 8 1 SYS(0.226)S(0.774)PDITQAIQEEEK 286.85 1.9326999999999998e-74 115480000.0 5982.4 5951.4 7327.6 7746.4 5307.9 5538.0 5678.6 4677.7 2805.6 4494.8 True False 6121.778280275972 5254.6073212692 6332.552167625661 6393.636657937214 4827.801382185859 5482.292748101681 5250.258630132914 4553.63220068901 4760.898287083452 5071.751363059605 1.2070343835985926 1.0360538096448175 1.24859278665535 1.260636849137684 0.9519002483736546 1.0809466702236783 1.0351963758265985 0.8978421603739595 0.9387089283910347 1.0 12.308268305361537 -6.269568743219847 24.860397227188578 0.9863884117191298 1.1815428644431367 0.6427928714704896 0.07441801404146552 403.7180574176273 1234607.1717158211 0.02455055259414546 0.02831682457304363 5.375653367222595e-07 6.269568743219847 0.1951544527240069 SYSSGGEDGYVR ddPTM_A459_Selumetinib_30min_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 168.74 0.005211 4520900.0 951.66 958.26 1117.1 1117.8 1307.2 1021.7 878.38 1148.0 770.65 950.34 False True 973.8318263919883 846.0664737170121 965.4039557910666 922.597213704717 1188.9639908049048 1011.4226256293764 812.1230894122049 1117.5513107704608 1307.7367639509778 1072.3253960955028 0.9081495504422964 0.7890016190959075 0.9002901165133707 0.8603705713433921 1.1087716425761254 0.943204953750156 0.757347622623941 1.0421755512269244 1.2195335191282823 1.0 10.066527041296796 -6.976716713688822 0.4472809769996709 1.0729548284536115 0.8406627911476706 0.2567939858854619 0.11697425129537621 1.7805387086049158 0.7715369019796142 0.12428065278479421 0.15661531363814293 1.055074887663411e-07 6.976716713688822 -0.23229203730594083 SYSSSSSS(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 SYSSSSSSPER 11 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 SYSSS(0.001)S(0.01)S(0.092)S(0.897)PER 117.86 0.005476600000000001 8855700.0 31374.0 32702.0 31249.0 31813.0 39718.0 26822.0 21848.0 25083.0 24009.0 34330.0 True False 29630.358680073008 35210.13824649681 29238.473361338663 27480.014519513967 34728.26975657487 30516.487034126225 22863.975290990686 25155.98737728581 28811.470867509728 33338.80369994802 0.8887649043063657 1.0561308247107772 0.8770102738084826 0.8242651646062757 1.0416771420214161 0.9153443929415441 0.6858067103057551 0.7545557904144303 0.8642023009228328 1.0 15.024914716413752 -7.028104872318494 23.869328167813634 0.804957187449651 0.9388986359059189 0.205841567617691 0.10103465731399518 537.4203050673866 456426.5549741681 0.03782966458693941 0.02938502258592226 9.373356341882565e-08 7.028104872318494 0.133941448456268 SYST(ph)DDEEDTQQSTGK ddPTM_A459_Selumetinib_30min_R1 2 SYSTDDEEDTQQSTGK 16 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8;Q4KWH8-3;Q4KWH8-4 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 SYS(0.004)T(0.996)DDEEDTQQSTGK;SYS(0.038)T(0.962)DDEEDTQQSTGK 232.26 4.4472999999999995e-15 8032800.0 1111.95 1466.1599999999999 1099.26 1801.05 1354.6999999999998 1287.91 1279.4299999999998 942.3599999999999 560.84 1217.58 True False 1137.8562715219427 1294.5013056007078 949.9865298029614 1486.5304273956708 1232.1676241917103 1274.9547947287174 1182.921565024997 917.36555158332 951.7045178670817 1373.8682532335397 0.828213526911246 0.9422310345653351 0.6914684341581303 1.0820036229070504 0.8968601037921049 0.9280036799219872 0.8610152845739539 0.6677245430369368 0.6927189092747049 1.0 10.4240279485563 -7.573315826665831 9.06203715014237 0.7604729210314108 0.8961785275889612 0.12062261195985013 0.12440262730249421 0.5281025065250367 88.30981547670214 0.05632207591359953 0.032472861292408346 2.6710632575290132e-08 7.573315826665831 0.13570560655755037 SYST(ph)DDEEDTQQSTGK ddPTM_A459_Selumetinib_30min_R2 2 SYSTDDEEDTQQSTGK 16 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8;Q4KWH8-3;Q4KWH8-4 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 SYS(0.047)T(0.953)DDEEDTQQSTGK;S(0.012)YS(0.039)T(0.949)DDEEDTQQSTGK 375.27 7.787199999999992e-221 12921400.0 78732.0 68009.0 76759.0 77390.0 79327.0 66424.0 68778.0 66987.0 46023.0 45048.0 True False 74356.39062916776 73225.07161659836 71820.40950888014 66849.34849480372 69361.23306762218 75573.30306296317 71976.31328102147 67181.9210797052 55228.88599006207 43747.34719123966 1.699677703978757 1.6738174156366117 1.6417089062548247 1.5280777644087684 1.585495750506025 1.7274945320135116 1.6452726371356894 1.5356798844515598 1.262451086431169 1.0 15.416907915121163 -8.407785278818675 1.7601239393187056 1.0029854509125746 1.6416346538788231 0.9387451515409123 0.05364713747290558 0.08115238901813383 0.5280128423727364 0.05627107347756304 0.016285984509975097 3.9103418069889786e-09 8.407785278818675 0.6386492029662485 SYVS(ph)EPELATLSGDMAQPSLGLVGPESR ddPTM_A459_Selumetinib_30min_R1 1 SYVSEPELATLSGDMAQPSLGLVGPESR 28 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 S(0.227)YVS(0.773)EPELATLSGDMAQPSLGLVGPESR 118.68 2.7012e-12 7960700.0 1743.7 2029.8 2329.0 2326.0 2313.1 1580.0 2145.5 1896.3 1230.9 1755.5 True False 1784.3248173504303 1792.1500723715799 2012.7345922812597 1919.807764427601 2103.880513410975 1564.1066345252189 1983.6632076480396 1846.0039639494987 2088.747398620981 1980.835525018052 0.9007940310108126 0.9047445129777988 1.0161038444940635 0.9691908995877409 1.062117720951012 0.7896196401823743 1.0014275201521146 0.9319319754893206 1.0544779575285261 1.0 10.951893378371624 -5.208518784777543 12.91171980062329 0.972457554652334 0.9027189519401215 0.14193238632483407 0.07304766897547008 4.014967858606606 974.8147556755455 0.018099572000892756 0.04789648986004917 6.187015659361297e-06 5.208518784777543 -0.06973860271221244 SYVS(ph)EPELATLSGDMAQPSLGLVGPESR ddPTM_A459_Selumetinib_30min_R2 1 SYVSEPELATLSGDMAQPSLGLVGPESR 28 0 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;A0A1B0GTN9;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 S(0.261)Y(0.003)VS(0.736)EPELATLSGDMAQPSLGLVGPESR 83.764 2.6655e-05 2025500.0 12345.0 13269.0 14322.0 12470.0 13973.0 12610.0 11726.0 9955.3 7480.9 11244.0 True False 11658.914320950505 14286.689633440352 13400.538112614568 10771.564488050148 12217.586819795073 14346.91303781716 12271.282234628196 9984.268274811362 8977.289033810386 10919.356504579531 1.0677290659079413 1.3083820120213654 1.227227823085952 0.9864651349676695 1.1188925661206381 1.3138973007979111 1.123810018427521 0.9143641633665869 0.8221445128241165 1.0 13.414600217949475 -7.730770367886466 4.317195966874765 0.8968894987276329 1.171863298252682 0.5572695996711547 0.10318985684515461 0.1493832795827905 6.2115352513620765 0.0562448613249304 0.029127241987989563 1.858787024261036e-08 7.730770367886466 0.2749737995250491 SYVS(ph)SPDPQLEENLK ddPTM_A459_Selumetinib_30min_R1 1 SYVSSPDPQLEENLK 15 0 E9PP00;Q9C0D7;Q9C0D7-2 E9PP00 ZC3H12C Probable ribonuclease ZC3H12C 1 SYVS(0.5)S(0.5)PDPQLEENLK 186.56 2.2643000000000007e-05 3940300.0 1310.2 1316.5 1240.0 1710.9 1539.0 1291.2 1446.1 1225.3 628.33 966.21 True False 1340.7251107945942 1162.363567975754 1071.6148108324444 1412.1234325705864 1399.7977217325179 1278.2117003157982 1337.0195127382108 1192.801063664674 1066.2301185925098 1090.2324651823938 1.2297607653522715 1.0661612134080898 0.9829232251427821 1.295249845943948 1.2839442654996835 1.1724212414661088 1.2263618589953933 1.09407956720966 0.9779841938701868 1.0 10.09042007159815 -8.053687863040247 3.5697914780673248 0.9923059938964583 1.1756431298063617 0.41427339224962856 0.09021988802667773 0.2712473612741899 6.7306112609867945 0.07332109138823205 0.02613912988367124 8.83714817428767e-09 8.053687863040247 0.1833371359099033 SYVTTSTR ddPTM_A459_Selumetinib_30min_R1 2 SYVTTSTR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 0 ; 138.83 0.033844 13486100.0 3699.3999999999996 3892.8 4450.8 4447.8 4001.4 3936.3 3764.2000000000003 4068.72 2312.37 2894.9 False True 3785.588822220667 3437.0291662863797 3846.405806494386 3671.075225546469 3639.4740765045494 3896.704395874442 3480.2633634251933 3960.8043285348335 3923.923001177344 3266.488613713905 1.1589168890188049 1.0522091373153677 1.177535348002065 1.1238597955412923 1.114185447095917 1.1929337146667716 1.065444817047206 1.2125572126306943 1.2012663949610265 1.0 11.673524895481165 -5.2801153261055305 24.756043262807246 1.141868895095556 1.1055629847026198 0.025918163870126798 0.06719822324061811 2180.262611533755 2890065.6669660225 0.016615839401821014 0.03471091283618641 5.246681170903312e-06 5.2801153261055305 -0.03630591039293618 SYVTTSTR ddPTM_A459_Selumetinib_30min_R2 1 SYVTTSTR 8 0 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 0 133.6 0.041826 6962300.0 23282.0 21397.0 33336.0 31778.0 36265.0 23514.0 23312.0 24277.0 21461.0 33465.0 False True 21988.07964523043 23038.081097801114 31191.19805349245 27449.781579892344 31709.06648678656 26752.840061160376 24396.05419185166 24347.64205072631 25753.799670441353 32498.77849748791 0.6765817258925613 0.7088906772167425 0.9597652433584071 0.8446404095469051 0.9757002556030715 0.8231952491146187 0.750676035215829 0.7491863748850848 0.7924543893990376 1.0 14.988097873421792 -5.1106574637426885 7.0674724019823385 0.8508723014372093 0.6846008079882007 0.3782090883884178 0.08624661877651521 0.26527897523971045 14.651016571843993 0.02304806308712335 0.06236405663970897 7.750728713951652e-06 5.1106574637426885 -0.1662714934490086 T(ph)AAPSPSLLYK ddPTM_A459_Selumetinib_30min_R2 1 TAAPSPSLLYK 11 0 Q9BTC0;Q9BTC0-1;Q9BTC0-2;Q9BTC0-3 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 T(0.847)AAPS(0.115)PS(0.039)LLYK 144.7 0.0017202 14708000.0 114990.0 92379.0 122820.0 123400.0 123910.0 96522.0 90095.0 93900.0 80023.0 121110.0 True False 108599.31614144173 99464.17225469796 114917.89491630487 106592.7071231267 108343.31803054514 109817.02936052246 94284.59601985555 94173.23345401819 96029.83602943634 117613.23961843025 0.9233596191531482 0.8456885685437042 0.9770829822316788 0.9062985380637657 0.9211830095152613 0.9337131577771274 0.8016495109372105 0.8007026569418724 0.8164883166298589 1.0 16.843690946658164 -7.25253195142967 24.845951098753936 0.8381020085466461 0.9169195804080396 0.18012963876150656 0.06209153210015616 780.361463223783 2176705.7151296325 0.022755192543328386 0.017361005717444155 5.590723946062657e-08 7.25253195142967 0.07881757186139349 T(ph)AAQVLIR ddPTM_A459_Selumetinib_30min_R2 1 TAAQVLIR 8 0 O60218 O60218 AKR1B10 Aldo-keto reductase family 1 member B10 1 T(1)AAQVLIR 106.62 0.031924 4122400.0 3248.0 2019.6 3147.4 3617.7 3746.0 1485.5 1278.4 929.41 1796.2 1659.1 True False 3067.489162774181 2174.496825962477 2944.899710630016 3124.9630191194065 3275.393990335098 1690.1141409736229 1337.8481331015432 932.1144292278912 2155.490190021283 1611.1974721405106 1.9038567374978284 1.3496153411124776 1.8277708111828486 1.9395282534597238 2.0328941963790856 1.04898013446376 0.8303439871490012 0.5785227728725002 1.3378187511414525 1.0 10.653917609630588 -6.849285138245707 5.691386302728954 0.9095859494755386 1.7913951419891463 0.749971349867204 0.245736892858692 0.10560955257100213 5.37419073628168 0.08933749897409425 0.07905805107458815 1.414864538449595e-07 6.849285138245707 0.8818091925136077 T(ph)ACNMT(ph)Y(ph)GSFGGVK ddPTM_A459_Selumetinib_30min_R2 1 TACNMTYGSFGGVK 14 0 F8WCG5;A0A5F9ZGY2;A0A5F9ZHP5;A0A5F9ZH74;A0A5F9ZH37;A0A5F9ZHE7;A0A5F9ZH14;A0A5F9ZGX9;Q3SYG4-5;Q3SYG4-6;Q3SYG4-2;Q3SYG4-4;Q3SYG4-7;Q3SYG4-3;Q3SYG4 F8WCG5 BBS9 Protein PTHB1 3 T(0.987)ACNMT(0.786)Y(0.752)GS(0.475)FGGVK 50.158 0.042425 3112900.0 8652.7 9642.7 7908.6 9151.9 10288.0 6986.9 6178.0 7289.1 5362.4 7767.6 True False 8171.81757350251 10382.264083832633 7399.769286232621 7905.395432091916 8995.529464113055 7949.282054236688 6465.289241474755 7310.310074224532 6435.029837974685 7543.329205351476 1.0833171072137704 1.3763503886940434 0.9809686260256268 1.0479982003812824 1.192514501121248 1.0538161384494815 0.8570869791667152 0.9691092454295072 0.8530755668743015 1.0 12.880985673938545 -7.055831699122627 4.495674961283536 0.9188193642417193 1.1356637379741807 0.4788408692408651 0.10634727985521418 0.19555569741620463 8.183975400700112 0.041494722044841295 0.032646975801454474 8.793632278832045e-08 7.055831699122627 0.21684437373246146 T(ph)ADGRVSPAGGTLDDKPK ddPTM_A459_Selumetinib_30min_R1 1 TADGRVSPAGGTLDDKPK 18 2 C9JA69;Q8WY36-2;Q8WY36 C9JA69 BBX HMG box transcription factor BBX 1 T(0.997)ADGRVS(0.003)PAGGTLDDKPK 93.729 0.014634 110040000.0 2916.3 4055.0 4340.3 4640.4 3214.5 3543.0 3952.6 2854.9 2295.9 3187.4 True False 2984.2441158680153 3580.2387148816424 3750.9110995613346 3830.0412510962324 2923.7490425660703 3507.360636786612 3654.4521997434854 2779.1787779778642 3895.9746140985503 3596.533837905176 0.8297556064719823 0.9954692145943983 1.0429239007927913 1.0649256822583002 0.8129352243962278 0.9752057939289392 1.0161039390837607 0.7727381148724614 1.0832581562385037 1.0 11.812391462393569 -3.4212909714974886 13.69380925073959 0.9572291551131895 0.36650292893504943 0.0 0.10630789036898643 0.0 0.0 0.02346848954071977 0.0 0.00037906093411904494 3.4212909714974886 -0.5907262261781401 T(ph)APSPLVEAK ddPTM_A459_Selumetinib_30min_R2 1 TAPSPLVEAK 10 0 Q8TEH3;Q8TEH3-7;Q8TEH3-6;A0A0A0MS48;Q8TEH3-4;Q8TEH3-3;Q8TEH3-5;Q8TEH3-2 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 T(0.739)APS(0.261)PLVEAK 147.28 0.0019427 29108000.0 188220.0 142060.0 167470.0 172530.0 167560.0 119440.0 139020.0 144370.0 96347.0 128030.0 True False 177759.48590435824 152955.54520510454 156695.1625275496 149031.1163691495 146509.61479459403 135891.77583163203 145484.70546290386 144790.09279825987 115619.09216010514 124333.44123811065 1.429699718227307 1.2302043897601111 1.2602817147758592 1.1986406463546713 1.1783604904332523 1.0929623959445154 1.1701172589945972 1.164530566808432 0.9299114623448997 1.0 16.923854856262814 -1.5228787452803378 0.17743277885350825 0.967806290629184 2.700313555914957 0.764153144458717 0.06376733419339226 28.46733996133218 0.31758666974492245 0.1480007702239281 13.241979303311647 0.02999999999999998 1.5228787452803378 1.7325072652857731 T(ph)AQELS(ph)FRR ddPTM_A459_Selumetinib_30min_R2 1 TAQELSFRR 9 1 H7C3K8;H7C2Z8;E9PCM6;E7EQN5;P98171;P98171-2 H7C3K8 ARHGAP4 Rho GTPase-activating protein 4 2 T(1)AQELS(1)FRR 87.639 0.046965 4904200.0 8654.3 7804.4 9785.3 9367.4 10705.0 7137.7 7921.6 10003.0 8530.6 6609.2 True False 8173.32865190782 8402.97238489877 9155.724451429076 8091.543960333679 9360.142196085753 8120.853385410587 8289.970096352616 10032.1070739142 10236.958364878947 6418.375223236128 1.2734264307761753 1.3092055376379217 1.4264863198217297 1.260684157423558 1.4583351503351958 1.2652506441211262 1.291599479310721 1.5630290727777112 1.5949454509637564 1.0 12.64799241782782 -7.715525971918936 24.999139770859387 1.434242486418096 1.3298047779662185 0.0014239501464646809 0.16457607777144764 319.0869618715867 173737.3946860401 0.07312786222090803 0.042220179693296486 1.925191910243063e-08 7.715525971918936 -0.1044377084518775 T(ph)AS(ph)PPPPPKR ddPTM_A459_Selumetinib_30min_R1 1 TASPPPPPKR 10 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 2 T(1)AS(1)PPPPPKR 96.067 0.032172000000000006 2188300.0 2200.8 2449.0 2803.8 3354.9 2324.3 2352.1 2124.3 2315.6 1532.4 2181.7 True False 2252.0743579886603 2162.2699414907893 2423.0593601709725 2769.0296942726404 2114.0674753884946 2328.440009535927 1964.0623407162582 2254.182765871148 2600.3708779322365 2461.7424465576087 0.9148293970142413 0.878349375871717 0.9842862983328216 1.1248251002637293 0.85876874664314 0.945850372280786 0.7978342102614007 0.9156858667417858 1.0563131336377125 1.0 11.265464116138903 -8.25593796391668 24.674876044188583 1.0281565710453453 0.9283734044447003 0.19150572346399208 0.08266961889292893 621.786406144964 2788864.5335459965 0.06301321068844178 0.02229804022025985 5.547049432172939e-09 8.25593796391668 -0.09978316660064501 T(ph)ASAPNLDR ddPTM_A459_Selumetinib_30min_R2 2 TASAPNLDR 9 0 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 T(0.994)AS(0.006)APNLDR;T(0.995)AS(0.005)APNLDR 126.03 0.011467 27205000.0 94966.0 76374.0 94586.0 108330.0 94137.0 65737.0 74397.0 77088.0 64871.0 68296.0 True False 89688.16989901877 82231.64021888415 88500.43973745003 93575.26712032678 82310.66846454226 74791.67504892839 77856.60791485873 77312.31331739457 77847.0126471833 66324.11702568158 1.352270846881992 1.2398452313664872 1.3343628789386142 1.4108784453789742 1.241036777506898 1.1276693667850572 1.173880805449873 1.1656742190394818 1.1737361330726785 1.0 16.017245943502857 -6.5611031730158915 4.08312616714939 1.1424760279427257 1.3281725899481522 0.7070906779417716 0.062168984418469575 0.12851167254783946 4.69340398161086 0.020620867153931563 0.02119233800264562 2.7472414281293585e-07 6.5611031730158915 0.1856965620054265 T(ph)ASEGDGGAAAGAAAAGAR ddPTM_A459_Selumetinib_30min_R1 5 TASEGDGGAAAGAAAAGAR 19 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 T(0.998)AS(0.002)EGDGGAAAGAAAAGAR;T(0.975)AS(0.025)EGDGGAAAGAAAAGAR;T(0.882)AS(0.118)EGDGGAAAGAAAAGAR;T(0.627)AS(0.373)EGDGGAAAGAAAAGAR;T(0.949)AS(0.051)EGDGGAAAGAAAAGAR 252.37 2.9402e-40 104162200.0 9154.82 10281.739999999998 9498.71 8833.230000000001 8192.56 9530.75 9800.87 10413.810000000001 6253.0 9886.53 True False 9368.109493821223 9077.949100948748 8208.837354679226 7290.672200763035 7451.544394513948 9434.87930822862 9061.582485174293 10137.601929977822 10610.884298949542 11155.56242845726 0.8397702539787382 0.8137598762202587 0.7358515007489814 0.6535459101698816 0.6679667154661288 0.8457555922201405 0.8122927502120975 0.9087486171129593 0.9511743013406234 1.0 13.44547563112266 -7.771364921946286 1.149186239853241 0.9892908789289735 0.7470464338411967 0.6947255931201534 0.05962425464828174 0.3127780550418206 0.7475798206823976 0.05766188452003458 0.022564475464994897 1.6929147076421092e-08 7.771364921946286 -0.24224444508777676 T(ph)ASEGDGGAAAGAAAAGAR ddPTM_A459_Selumetinib_30min_R2 2 TASEGDGGAAAGAAAAGAR 19 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 T(0.971)AS(0.029)EGDGGAAAGAAAAGAR;T(0.992)AS(0.008)EGDGGAAAGAAAAGAR 265.43 1.1029000000000002e-47 190109000.0 41215.0 34894.0 39538.0 40809.0 29215.0 29067.0 39512.0 43621.0 27231.0 33590.2 True False 38924.435296717296 37570.257598105905 36994.168125719516 35250.7438005484 25544.750514586223 33070.71540604531 41349.38629154268 43747.92988815469 32677.960897711608 32620.363648179256 1.193255713410476 1.1517424515346546 1.1340820269422223 1.0806361382337306 0.7830921442229855 1.0138058472530607 1.2675942775349975 1.3411233044484019 1.0017656838578979 1.0 14.993485244692458 -10.253546350259024 15.33136712650109 1.0000251034215046 1.1080402633083755 0.04585888650779968 0.14702094863420845 0.0 0.0 0.15586562439749396 0.037802966634924516 5.577680709353966e-11 10.253546350259024 0.10801515988687083 T(ph)ASELLLDRR ddPTM_A459_Selumetinib_30min_R2 2 TASELLLDRR 10 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 T(0.996)AS(0.004)ELLLDRR;T(0.993)AS(0.007)ELLLDRR 137.4 0.0021851 4427600.0 43981.0 12763.0 35235.0 34800.0 19491.6 14785.0 47945.0 29352.0 22718.0 21564.2 True False 41536.71208989262 13741.881060486781 32968.01846096733 30060.179966651558 17042.89095088511 16821.499545132952 50174.53750121514 29437.409460514824 27262.23479395587 20941.585515479714 1.983455935520703 0.6562006038334101 1.5742847377338194 1.4354299938002073 0.8138300196175334 0.8032581646073906 2.395928305625515 1.405691533659432 1.3018228621612258 1.0 14.354083054326576 T(ph)ASESISNLSEAGS(ph)IK ddPTM_A459_Selumetinib_30min_R2 1 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 2 T(0.691)AS(0.21)ES(0.034)IS(0.022)NLS(0.045)EAGS(0.999)IK 149.36 0.044614 4457800.0 59786.0 48533.0 44092.0 43717.0 41230.0 49396.0 54289.0 44953.0 31263.0 45808.0 True False 56463.33346232053 52255.325041808755 41255.1687237398 37762.66918396857 36050.31879912338 56199.85062775698 56813.54607161265 45083.80578763021 37516.47356120442 44485.40401652253 1.2692552694665697 1.174662256015487 0.9273866256990051 0.8488777390881505 0.8103853296630454 1.2633323641813736 1.27712779792921 1.0134516429453002 0.8433434379346144 1.0 15.441044434568486 -5.074428691669089 4.428688984648995 1.006524148865204 1.2519408022038772 0.2609559340718749 0.15369530097442502 0.31737439802778844 11.452551926485047 0.044444864595728564 0.1390432861448676 8.425027135513913e-06 5.074428691669089 0.24541665333867324 T(ph)ASESNVYLNSFHYPDHSYK ddPTM_A459_Selumetinib_30min_R1 1 TASESNVYLNSFHYPDHSYK 20 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;E9PGF6;A0A1W2PRT1;A0A1W2PRJ2 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 T(0.378)AS(0.378)ES(0.175)NVY(0.001)LNS(0.063)FHY(0.005)PDHSYK 76.241 0.007809100000000002 8655700.0 1370.8 1587.3 1195.1 1208.7 1561.8 1419.3 1757.3 1536.8 697.68 1233.3 True False 1402.736972887521 1401.4581780842495 1032.8119842143976 997.6232351090458 1420.5354657581863 1405.0231306212934 1624.7454461896534 1496.0390717700739 1183.9120034689136 1391.6060683593064 1.0079986030395354 1.0070796685563168 0.7421726648778383 0.7168862351148242 1.0207884961532163 1.0096414226461412 1.1675325964230787 1.075044946831752 0.8507522569693429 1.0 10.4425351598886 -6.468305096649927 20.474036907714776 1.0323290639258693 0.8693325491546646 0.2930729258043878 0.11499858028727343 57.727567031977166 21656.541081372456 0.03853673850609844 0.043695088119874076 3.401691331836594e-07 6.468305096649927 -0.1629965147712047 T(ph)ASESNVYLNSFHYPDHSYK ddPTM_A459_Selumetinib_30min_R2 1 TASESNVYLNSFHYPDHSYK 20 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;E9PGF6;A0A1W2PRT1;A0A1W2PRJ2 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 T(0.362)AS(0.362)ES(0.253)NVY(0.023)LNSFHYPDHSYK 59.56100000000001 0.025074000000000003 11108000.0 22506.0 15051.0 28663.0 38712.0 37241.0 30936.0 23624.0 28682.0 27317.0 32156.0 True False 21255.206618656306 16205.363303407234 26818.85378591476 33439.35881807516 32562.45264123583 35197.153190952544 24722.562810067942 28765.459871439278 32781.163300752385 31227.572728678366 0.680655099367881 0.5189440576828683 0.858819672567289 1.0708279861715144 1.042746835437887 1.127117803767971 0.7916901843403141 0.921155804242897 1.049750602955037 1.0 14.930532814793612 -5.445089279248297 4.043706128990934 0.994606454783225 0.6041200972915823 0.7358316723028044 0.09482434655591429 0.11562311877272967 3.5138703657987467 0.026827870267607492 0.058200276327543585 3.5884815754591086e-06 5.445089279248297 -0.3904863574916426 T(ph)ASGSSVTSLDGTR ddPTM_A459_Selumetinib_30min_R1 1 TASGSSVTSLDGTR 14 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 T(0.853)AS(0.14)GS(0.007)SVTSLDGTR 185.2 0.00018487 20044000.0 1213.2 1645.6 1699.0 1509.1 1345.8 1360.4 1557.2 1418.0 971.82 1184.2 True False 1241.4651995237384 1452.9323869813156 1468.2851319389688 1245.564014315431 1224.072627620288 1346.7156111443717 1439.7391502910875 1380.3900336868587 1649.1075610755067 1336.2036050848055 0.9290988250588844 1.0873585293830288 1.0988483539121872 0.9321663327172195 0.916082416603418 1.0078670690750748 1.0774848569576423 1.0330686344759927 1.2341738600314898 1.0 10.38392414102613 -7.521764384865222 1.9294104402303414 1.1048632100306772 0.9981728852914565 0.22705800655924446 0.08156641604172132 0.542206804328179 3.973190054755442 0.05087983496621104 0.025804116333310218 3.007707613331194e-08 7.521764384865222 -0.10669032473922069 T(ph)ASGSSVTSLDGTR ddPTM_A459_Selumetinib_30min_R2 2 TASGSSVTSLDGTR 14 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 T(0.924)AS(0.076)GSSVTSLDGTR;T(0.984)AS(0.016)GSSVTSLDGTR 225.33 2.28e-09 305230000.0 203073.0 178749.0 209691.0 201951.0 229524.0 199867.0 178244.0 161621.0 139524.0 229766.0 True False 191787.0156256284 192458.4735313762 196199.70935429836 174444.92541509314 200689.14314940575 227396.86503801722 186532.6991837855 162091.29035220298 167432.69862628286 223132.05857623773 0.8595224588048175 0.8625316987590949 0.8792986118006106 0.7818012639160516 0.8994186869872672 1.0191133738871607 0.8359744465856425 0.726436583727484 0.7503749111384458 1.0 17.767538282623306 -11.704700002006458 2.3199592724208355 1.4002479483760788 0.8484703178339378 0.25518970488024184 0.07880412446942957 14937010.74345857 3898482.1623734077 31289034.637169626 0.021654971955989654 1.973785699052336e-12 11.704700002006458 -0.551777630542141 T(ph)ASISSSPSEGTPTVGSYGCTPQSLPK ddPTM_A459_Selumetinib_30min_R2 1 TASISSSPSEGTPTVGSYGCTPQSLPK 27 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 T(0.963)AS(0.034)IS(0.003)SSPSEGTPTVGSYGCTPQSLPK 186.42 6.5274e-32 11469000.0 81318.0 73437.0 85322.0 88466.0 86104.0 68178.0 70490.0 80630.0 59339.0 92780.0 True False 76798.67110174596 79069.3817628275 79832.47541156966 76416.77818763796 75286.8457404734 77568.9006417365 73767.92467328507 80864.619950985 71208.45807018869 90101.20032860995 0.8523601330687265 0.877561913431252 0.8860312084679337 0.8481216444280071 0.8355809408297914 0.8609086267312018 0.8187229959672518 0.8974866001347592 0.7903164198754605 1.0 16.459258705306333 -11.08603469708978 5.790376851044701 1.000432277538045 0.8536966287881161 0.682119543809893 0.0303082530924608 0.00016024506312422367 1.2089358266700719e-05 0.027803468136181043 0.006723688780472998 8.202860066005334e-12 11.08603469708978 -0.14673564874992884 T(ph)ASLPGYGR ddPTM_A459_Selumetinib_30min_R2 2 TASLPGYGR 9 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 T(0.735)AS(0.265)LPGYGR;T(0.993)AS(0.007)LPGYGR 131.52 0.0083824 126982000.0 140419.0 120744.0 154513.0 144809.0 150501.0 119036.0 96079.0 102479.0 89740.0 107315.0 True False 132615.0741217941 130004.67654684764 144571.80180103445 125085.76439054159 131593.71888398894 135432.1284987791 100546.86387692683 102777.19692368833 107690.507545101 104216.53711214475 1.2724954963634074 1.2474476714473148 1.3872251545401517 1.2002487115450784 1.2626951780443856 1.299526277226464 0.9647879949103559 0.9861889463194542 1.0333341572193864 1.0 16.66922469751085 -7.260433299164602 24.999998236367887 0.9949268435242071 1.2775696514972024 0.896243709415663 0.047037059243423274 26.96551797329064 670074.9135064711 0.018682182111415188 0.013618512912642766 5.4899286584457094e-08 7.260433299164602 0.28264280797299524 T(ph)ASLTSAASVDGNR ddPTM_A459_Selumetinib_30min_R2 2 TASLTSAASVDGNR 14 0 G3V578;H0YJT9;A0A0A0MS87;Q9UN36-4;Q9UN36-5;Q9UN36-2;Q9UN36-3;Q9UN36-6;Q9UN36 G3V578 NDRG2 Protein NDRG2 1 T(0.984)AS(0.001)LT(0.014)SAASVDGNR;T(0.869)AS(0.039)LT(0.071)S(0.021)AASVDGNR 223.58 7.936800000000001e-09 36943000.0 62026.0 44742.0 54096.0 57133.0 57492.0 45158.0 48121.0 54473.0 38738.0 56493.0 True False 58578.84322975098 48173.56753179498 50615.52225527145 49351.38684007773 50269.340974998806 51378.10459649063 50358.72184995258 54631.5074115094 46486.682430155044 54861.90030355848 1.067750896444092 0.8780878399261413 0.9225987793935092 0.8995566425335192 0.91628873037302 0.936498814518062 0.9179179279483722 0.9958004937711912 0.8473399968454939 1.0 15.743516974594526 -10.74543284522607 4.95764934976114 1.0000098220423268 0.9297726351094884 0.10995074511094405 0.05847751559037612 5.885920421810911e-06 9.230114034760433e-07 0.05249529736700395 0.012730199398272572 1.7970789402544767e-11 10.74543284522607 -0.07023718693283842 T(ph)ASNPKVENEDEPVR ddPTM_A459_Selumetinib_30min_R1 1 TASNPKVENEDEPVR 15 1 Q9UBF8-2 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 T(0.585)AS(0.415)NPKVENEDEPVR 114.06 0.027027 15441000.0 3333.1 4311.9 3933.4 3537.3 3239.4 3404.0 3745.3 3778.7 1676.5 3398.4 True False 3410.7547449163953 3807.0607434520753 3399.2658846196255 2919.576958344691 2946.396841962521 3369.758850584712 3462.7890056416727 3678.47660105256 2844.8980532846463 3834.6177432192235 0.8894640804673823 0.9928136253435228 0.8864679903572049 0.7613736632568906 0.768367811152142 0.8787730815003597 0.9030336887594448 0.9592811715215243 0.7418987350995535 1.0 11.90486705340766 -10.112533171904808 18.449907008147207 0.9999999999479184 0.867486251996078 0.20619984646578915 0.07951362970056214 0.0 0.0 0.08154731874722852 0.019778129922396148 7.717325675255022e-11 10.112533171904808 -0.13251374795184045 T(ph)ASPPPPPK ddPTM_A459_Selumetinib_30min_R2 1 TASPPPPPK 9 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.939)AS(0.061)PPPPPK 122.94 0.01353 217980000.0 367600.0 348890.0 369560.0 437600.0 409140.0 307610.0 314530.0 302980.0 277360.0 323470.0 True False 347170.26361939334 375648.7411418337 345782.9119465048 377998.12509789487 357740.1754419926 349980.48529444356 329156.2682293709 303861.6216389609 332839.7500859056 314130.5806240083 1.105178180773591 1.1958362678209231 1.1007616999899223 1.2033152720980431 1.1388263273551893 1.1141242110182994 1.0478326165364562 0.9673099035291358 1.0595585740959452 1.0 18.261004870680637 -7.2345506172566605 2.142098666315378 1.0091018350121252 1.1512341686928762 0.7320428259062357 0.037722232504452086 0.15454145975945066 1.387362125016238 0.017198972640013292 0.01134406887126734 5.827058561559023e-08 7.2345506172566605 0.14213233368075096 T(ph)ASPPPPPKR ddPTM_A459_Selumetinib_30min_R1 1 TASPPPPPKR 10 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.955)AS(0.045)PPPPPKR 135.43 0.0024537 275790000.0 9953.0 12027.0 13856.0 14399.0 12766.0 11526.0 11807.0 11344.0 6801.7 10863.0 True False 10184.885534833307 10618.873248799391 11974.431305559949 11884.484952705512 11611.317554020357 11410.058904770673 10916.388484129766 11043.12026949487 11541.988123487141 12257.371864580522 0.830919192740169 0.8663254542749238 0.976916702687452 0.9695785592544091 0.9472925911281983 0.9308731945827404 0.8905978055274864 0.9009370354019844 0.9416364495589313 1.0 13.581362059688203 -5.086918877100223 4.756433742304357 0.9394986870145038 0.83804167810984 0.5986581223550898 0.031783086164538885 0.14944771121062386 5.683800919622181 0.008764445648271054 0.026160032355218046 8.18617685399865e-06 5.086918877100223 -0.1014570089046638 T(ph)ASTDLK ddPTM_A459_Selumetinib_30min_R2 2 TASTDLK 7 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 T(0.799)AS(0.2)T(0.001)DLK;T(0.661)AS(0.338)T(0.001)DLK 117.81 0.026485 41789000.0 298000.0 195603.0 178937.0 220553.0 160825.0 169178.0 451590.0 730720.0 278530.0 393160.0 True False 281438.3529885175 210605.1211372242 167424.38823187494 190513.3009248537 140620.7257062579 192480.73385502235 472589.8298086084 732846.2742227925 334243.7827784374 381808.4492476425 0.737119237521052 0.5515989013659174 0.43850362285535177 0.49897612611837733 0.36830176488590677 0.5041290579983435 1.2377668193038984 1.9194082154726373 0.8754226980494232 1.0 18.5424895037182 -7.288614674438777 5.139835428667826 1.3446912837105842 0.5049465703893521 0.6326811741976164 0.2743780636263554 0.10973140601213538 8.343709245910723 0.11052615055418558 0.07601196816986619 5.1449993657551844e-08 7.288614674438777 -0.8397447133212321 T(ph)ATCHSSSSPPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R2 2 TATCHSSSSPPIDAASAEPYGFR 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.308)AT(0.308)CHS(0.073)S(0.073)S(0.073)S(0.164)PPIDAASAEPYGFR;T(0.393)AT(0.343)CHS(0.008)S(0.086)S(0.078)S(0.092)PPIDAASAEPYGFR 85.945 0.00035906 874753000.0 731482.5 782219.6 1353795.6 1966903.7 2568290.9 1640806.9 761586.4 1325072.3 1510451.6 1731310.4 True False 690829.6310064538 842213.3280875614 1266693.8649972016 1699008.0229618654 2245639.236330039 1866813.1567129553 797001.6766548229 1328928.0410154702 1812584.1255439005 1681322.9702673568 0.4108845493835137 0.5009229892063131 0.7533911612447531 1.010518533920759 1.3356382301569025 1.110323947109402 0.4740324677346715 0.7904061649762327 1.078070161175322 1.0 20.681165452046727 -5.393543839998927 2.509385419200159 0.9610079692227054 0.4354383349501565 0.4826717974747242 0.21247639635811788 0.28882364793664717 3.473332267055122 0.06677065000608294 0.17982706668576717 4.040695835180496e-06 5.393543839998927 -0.5255696342725489 T(ph)ATFTDARIR ddPTM_A459_Selumetinib_30min_R1 1 TATFTDARIR 10 1 A0A2R8YDC1;A0A2R8Y6V8;O15439-4;O15439-3;O15439-2;O15439 A0A2R8YDC1 ABCC4 Multidrug resistance-associated protein 4 1 T(0.494)AT(0.494)FT(0.013)DARIR 86.13600000000002 0.020143 3107600.0 766.14 1170.0 1292.3 1027.1 1350.4 850.95 859.02 1048.2 597.09 751.34 True False 783.9895713510685 1033.0158560817565 1116.8127580957803 847.7362660548539 1228.2565584324836 842.3902156007816 794.2234297990306 1020.3983309665487 1013.2181202718346 847.7818076713543 0.9247539452450542 1.2184925964844588 1.31733513032485 0.9999462814416537 1.4487885294521698 0.9936403541314692 0.936825280528919 1.2036096100827276 1.19514020129176 1.0 9.727549198083373 T(ph)AVPSPVEAAAASDPAAAR ddPTM_A459_Selumetinib_30min_R1 1 TAVPSPVEAAAASDPAAAR 19 0 Q147X3;Q147X3-2;J3KNC2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 T(0.531)AVPS(0.469)PVEAAAASDPAAAR 182.49 6.7938e-13 21432000.0 7999.1 10036.0 10123.0 10710.0 9615.7 8519.5 8958.4 7931.7 4881.9 7118.1 True False 8185.46346646087 8860.980454390177 8748.352201658736 8839.699551599146 8745.961632789718 8433.801565087084 8282.660675550782 7721.325550207373 8284.227740131415 8031.777471165481 1.0191347426951418 1.1032402835115365 1.0892174531809176 1.100590695314225 1.0889198143484673 1.0500541873034819 1.0312363241245148 0.9613470465195721 1.0314314321919704 1.0 12.971503583122415 -7.230311962918881 2.026619799672285 0.9978785900519035 1.082556439321352 0.611626019149281 0.028143342440163737 0.2089971149007944 1.6781340220025345 0.013583716100039774 0.008887731562916569 5.8842082837510535e-08 7.230311962918881 0.08467784926944855 T(ph)CNSPQNSTDSVSDIVPDSPFPGALGSDTR ddPTM_A459_Selumetinib_30min_R2 1 TCNSPQNSTDSVSDIVPDSPFPGALGSDTR 30 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 T(0.505)CNS(0.417)PQNS(0.033)T(0.022)DS(0.022)VSDIVPDSPFPGALGSDTR 117.22 9.5954e-10 0.0 4472.0 2923.3 5722.6 5900.3 4489.8 4445.9 2899.1 2829.6 3188.4 2761.5 True False 4223.464142834402 3147.5077101089873 5354.414146295777 5096.668961414779 3925.75118467873 5058.282369138084 3033.913894457666 2837.833667534503 3826.1690913394186 2681.768319761328 1.5748803174803268 1.173668764343189 1.9965983291100662 1.9004881681458496 1.463866641928306 1.8861742574348335 1.1313109607945844 1.0581949404887685 1.4267336455372626 1.0 11.388968891640195 -7.276114055066714 24.799584924518946 1.1589094079428923 1.6600750586847994 0.5065125275712115 0.24746744148185282 663.2070822567167 1120787.3367138274 0.1062257515646014 0.07196826138050152 5.295243611492955e-08 7.276114055066714 0.5011656507419071 T(ph)CSFGGFDLTNR ddPTM_A459_Selumetinib_30min_R1 1 TCSFGGFDLTNR 12 0 O94885;A0A1B0GWB9 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 T(0.864)CS(0.131)FGGFDLT(0.005)NR 166.45 0.0010991 18466000.0 2177.8 2577.1 2912.1 2756.5 2364.0 2179.3 2587.0 2523.5 1146.5 1988.6 True False 2228.5385027388693 2275.371933938715 2516.6528150202885 2275.129020913449 2150.1766173980973 2157.3782206460805 2391.8605071943502 2456.5685825167743 1945.5267629530856 2243.856180604329 0.9931735028305895 1.0140453535332634 1.1215749194507145 1.0139370965837469 0.9582506383359198 0.9614601146429279 1.0659598096657692 1.0947976986007883 0.8670461056149795 1.0 11.131764494397471 -5.989508729627269 24.98082632080516 0.9971340125972015 1.0446615530921899 0.10590031516386356 0.06595062095375406 549.0362776838369 1307299.7273274078 0.018945234944094638 0.02806928173018808 1.024451187907577e-06 5.989508729627269 0.04752754049498842 T(ph)CSFGGFDLTNR ddPTM_A459_Selumetinib_30min_R2 3 TCSFGGFDLTNR 12 0 O94885;A0A1B0GWB9 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 T(0.678)CS(0.321)FGGFDLT(0.001)NR;T(0.93)CS(0.07)FGGFDLTNR;T(0.91)CS(0.089)FGGFDLTNR 128.21 0.0058066 21154600.0 101692.0 88593.0 99636.0 108264.0 97559.0 74356.0 86299.0 88972.0 70550.0 88298.0 True False 96040.36574533005 95387.7982286066 93225.52823547457 93518.25643418271 85302.76623147413 84597.86406343638 90312.07449822442 89230.89378989252 84661.97133170108 85748.60731424451 1.1200224557976686 1.112412215384877 1.0871958292433748 1.0906096246142474 0.9948006026367694 0.9865800356781192 1.053219140542494 1.0406104143812671 0.9873276544473636 1.0 16.38782561949788 -6.172588042749549 4.714223322031818 1.0135003625231385 1.1041992609346927 0.8051722983247961 0.022224653081251607 0.10860169556006047 4.156429598433448 0.00721720616527997 0.009405032064991806 6.720660500903241e-07 6.172588042749549 0.09069889841155421 T(ph)CSLPDLSK ddPTM_A459_Selumetinib_30min_R1 1 TCSLPDLSK 9 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 T(0.995)CS(0.005)LPDLSK 127.83 0.010453 17175000.0 4438.8 6698.7 6666.5 7160.4 5903.8 5274.1 5571.9 5650.3 2974.7 4338.0 True False 4542.215403598723 5914.413089858855 5761.225916463297 5909.970557354858 5369.802332400545 5221.047342499654 5151.607097037575 5500.435689238968 5047.848636508105 4894.824555698266 0.9279628619806085 1.2082993011411705 1.1770035577182063 1.2073917032378247 1.0970367316126455 1.0666464718171809 1.0524600092234926 1.1237247886312258 1.0312624240294166 1.0 12.257041435163142 -6.512275157014556 6.8375579067542525 1.0642511989744712 1.1407899405823283 0.1544095760822377 0.08031610363796639 0.27524630662935917 67.18507273828382 0.025522259785974638 0.027257545699692274 3.074148501840126e-07 6.512275157014556 0.07653874160785712 T(ph)CSPESQQIYGDIK ddPTM_A459_Selumetinib_30min_R2 1 TCSPESQQIYGDIK 14 0 Q4VC44-2;Q4VC44;Q4VC44-4;Q4VC44-3;I3L287;J3KNW1;Q4VC44-5 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 T(0.546)CS(0.438)PES(0.016)QQIYGDIK 179.81 0.00017081 6821900.0 34310.0 28906.0 39941.0 41456.0 36386.0 28206.0 32939.0 37449.0 29721.0 30106.0 True False 32403.18755381223 31122.9972525606 37371.23954447271 35809.62128441113 31814.865385032834 32091.120471425093 34470.72876739026 37557.9703899843 35666.03047412457 29236.761555218043 1.1083028977957736 1.0645158901672511 1.2782277364711367 1.22481490355145 1.0881802119207236 1.0976291067947508 1.1790200738302388 1.284614587667324 1.219903593178878 1.0 14.835495897851692 -7.513216683703646 24.79081673472796 1.197718908541606 1.1465583375650128 0.0 0.09197457465591001 1381.6658396813123 3545088.5028431704 0.04150692448614818 0.02579930704559161 3.067491134996895e-08 7.513216683703646 -0.05116057097659321 T(ph)DGSFIGYK ddPTM_A459_Selumetinib_30min_R1 1 TDGSFIGYK 9 0 A0A5K1VW74;Q9Y243-2;Q9Y243;A0A5F9ZGZ4;A0A5F9ZHA9;F8VS91 A0A5K1VW74 AKT3 RAC-gamma serine/threonine-protein kinase 1 T(0.896)DGS(0.104)FIGYK 112.3 0.022863 7117000.0 2271.8 3007.8 2851.7 3100.6 2369.8 2715.4 2585.2 2619.0 1643.2 1859.0 True False 2324.7285198467084 2655.6453777117163 2464.4548032668386 2559.1384154704306 2155.452008422172 2688.085541385936 2390.19628264354 2549.535612289058 2788.3903854204204 2097.620758193426 1.1082692191933106 1.2660274109791365 1.1748810139490362 1.2200195890864878 1.0275699265479015 1.2814926296310336 1.139479704950143 1.215441638976172 1.3293110179849286 1.0 11.03453815241035 T(ph)DGSFIGYK ddPTM_A459_Selumetinib_30min_R2 1 TDGSFIGYK 9 0 A0A5K1VW74;Q9Y243-2;Q9Y243;A0A5F9ZGZ4;A0A5F9ZHA9;F8VS91 A0A5K1VW74 AKT3 RAC-gamma serine/threonine-protein kinase 1 T(0.545)DGS(0.455)FIGYK 106.18 0.031146 3586200.0 24149.0 21651.0 24597.0 27375.0 23470.0 21381.0 18625.0 17664.0 16045.0 23111.0 True False 22806.89525610642 23311.562081062402 23014.455799188698 23646.477775491003 20521.48877553785 24326.03867260654 19491.09940473736 17715.39931556737 19254.448334757548 22443.725380410662 1.0161813544560985 1.0386672304148403 1.0254293977093563 1.0535896948788246 0.9143530509177153 1.0838681306374742 0.8684431427658434 0.7893252575185102 0.8578989454024963 1.0 14.454024544879475 -7.280321182677941 22.41808065532292 0.8613604985993514 1.0194684375189758 0.5371695549600031 0.06422452234239773 150.72647477048181 178953.31832288354 0.025595223298813533 0.017306544765105878 5.244194821406696e-08 7.280321182677941 0.15810793891962438 T(ph)DSPSCEYSR ddPTM_A459_Selumetinib_30min_R2 1 TDSPSCEYSR 10 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 T(0.867)DS(0.133)PSCEYSR 160.77 0.001021 5840200.0 48786.0 38725.0 47118.0 49727.0 52071.0 41200.0 48014.0 54664.0 34019.0 43560.0 True False 46074.66942583161 41695.08297949941 44086.4791781995 42954.096816140336 45529.375459353694 46874.926023637345 50246.746137936076 54823.06318988762 40823.75057027839 42302.30961752796 1.0891762138382293 0.9856455440963219 1.0421766465425395 1.0154078395365513 1.076285807347233 1.1080937766153252 1.1878014839434758 1.2959827414995728 0.9650477938292776 1.0 15.368448813173401 -6.651795382731569 2.4413093354229574 1.1367708282744833 1.0310038744516024 0.11442141360646019 0.09082894604794875 0.4528793265941677 5.501427855825383 0.0326838002510825 0.0323272275976158 2.2294853209057097e-07 6.651795382731569 -0.10576695382288093 T(ph)DTEEEEEQQQQQK ddPTM_A459_Selumetinib_30min_R2 1 TDTEEEEEQQQQQK 14 0 Q9UGU0-2;Q9UGU0;A9JX13 Q9UGU0-2 TCF20 Transcription factor 20 1 T(0.609)DT(0.391)EEEEEQQQQQK 169.3 0.00042179 3401900.0 15048.0 17900.0 15863.0 13499.0 14985.0 12696.0 15700.0 13623.0 10353.0 12190.0 True False 14211.692401916835 19272.87244242839 14842.391850328502 11660.412912926144 13102.450332400287 14444.75875718688 16430.081108959806 13662.64067459095 12423.889286989393 11838.043026576355 1.2005102845133817 1.6280454800815367 1.2537876249484308 0.9849949765133111 1.106808811472077 1.22019819701267 1.387905169129251 1.1541300064477196 1.0494884381732534 1.0 13.531142985076707 -1.5228787452803376 0.16427533381710419 1.0262830881232978 2.4258645656105426 0.23250212979302276 0.1618909692577605 101.48839862014164 1.071651913514156 0.49374842858119894 34.58877585257921 0.029999999999999995 1.5228787452803376 1.3995814774872448 T(ph)DTGIVTVEQSPSSSK ddPTM_A459_Selumetinib_30min_R1 1 TDTGIVTVEQSPSSSK 16 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.948)DT(0.011)GIVTVEQS(0.026)PS(0.003)S(0.001)S(0.011)K 175.6 2.9247e-06 26353000.0 5614.0 6726.8 7136.4 6701.4 6102.5 6122.4 6330.5 6186.6 3833.2 5213.9 True False 5744.79527705759 5939.223128795523 6167.316077439235 5531.126290857752 5550.529952483884 6060.814214694426 5852.985288285213 6022.511271091054 6504.660434148945 5883.154852686769 0.9764820782227087 1.0095303077197004 1.048300823600231 0.9401633017243716 0.9434614745775425 1.0301979748036925 0.9948718731434074 1.0236873619501352 1.1056415472692074 1.0 12.522374295120866 -7.958184698326186 4.182114775086475 1.0566073694870035 0.9926401601979608 0.2728347571613915 0.03989702348562343 0.2598125239117503 9.779814238268006 0.025264329881427173 0.010768347892945934 1.1010709425259244e-08 7.958184698326186 -0.06396720928904276 T(ph)EARSSDEENGPPS(ph)SPDLDR ddPTM_A459_Selumetinib_30min_R2 1 TEARSSDEENGPPSSPDLDR 20 1 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 2 T(0.604)EARS(0.296)S(0.1)DEENGPPS(0.548)S(0.452)PDLDR 105.79 0.0016436 10991000.0 26435.0 32437.0 23136.0 27591.0 25382.0 14954.0 13805.0 16620.0 13751.0 31886.0 True False 24965.848527689483 34924.813598606124 21647.454948572158 23833.05820287022 22193.286242040977 17013.777761103698 14446.959854088549 16668.36144841088 16501.58423504213 30965.368330222613 0.8062506559407685 1.1278668874905338 0.6990859826926055 0.7696681644057447 0.7167131359577606 0.5494453539084185 0.46655217209181793 0.5382904304788242 0.5329045034783702 1.0 14.918367986432441 -5.816042241642463 1.1207620010913244 0.5887082618024697 0.9618225254642653 0.31550262824008035 0.16883746833251345 0.5415387107725474 1.3375970642714354 0.06056111408956311 0.15560003981348178 1.5274174867872317e-06 5.816042241642463 0.37311426366179556 T(ph)EESPASDEAGEK ddPTM_A459_Selumetinib_30min_R2 1 TEESPASDEAGEK 13 0 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 T(0.879)EES(0.119)PAS(0.002)DEAGEK 171.36 0.00047665 24099000.0 215360.0 200910.0 217260.0 211820.0 200580.0 144170.0 201520.0 214710.0 155910.0 165060.0 True False 203391.15335438662 216319.15097253007 203281.72813480243 182969.75059011858 175381.34719204853 164028.10885504363 210891.0793043045 215334.77055284628 187096.35648937707 160294.28892261657 1.2688608853218435 1.3495125274048907 1.2681782333052327 1.141461444571171 1.0941209968916321 1.0232935306524213 1.3156493641898492 1.3433714451099439 1.167205380471786 1.0 17.290363499493864 -5.624622897979066 4.582982775267695 1.1683513205824863 1.3092137368995098 0.269714143399554 0.10554227789544735 0.32124065247720557 11.53907159340919 0.03137643431910888 0.05619830808813838 2.3734336861801106e-06 5.624622897979066 0.14086241631702356 T(ph)EGTPPPPGQPAK ddPTM_A459_Selumetinib_30min_R1 2 TEGTPPPPGQPAK 13 0 F8VWT9;J3KPF0;Q9Y4D8-2;Q9Y4D8-4;Q9Y4D8;A0A494C150 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 1 T(0.777)EGT(0.223)PPPPGQPAK;T(0.528)EGT(0.472)PPPPGQPAK 126.32 0.0047701 26877000.0 12339.1 13483.4 15218.800000000001 16761.699999999997 13977.7 12864.9 13097.1 12739.5 7172.3 10478.3 True False 12626.577022290923 11904.757259737398 13152.170550884512 13834.583751077438 12713.419502963376 12735.490786394608 12109.175202464294 12401.607076272026 12170.86925593408 11823.291872285197 1.0679409050104476 1.0068902458242752 1.1123949821212076 1.170112681012881 1.0752859390001792 1.077152701968534 1.0241796729089663 1.0489132138691806 1.0293976827607236 1.0 13.529344149973674 -7.168295564420748 3.156910810796357 1.0291696822941439 1.0876114640013035 0.3477234387237127 0.03973791046292431 0.36314064012407316 6.953651151848113 0.018491083451436657 0.013603150021661398 6.787415495348482e-08 7.168295564420748 0.058441781707159635 T(ph)EGTPPPPGQPAK ddPTM_A459_Selumetinib_30min_R2 1 TEGTPPPPGQPAK 13 0 F8VWT9;J3KPF0;Q9Y4D8-2;Q9Y4D8-4;Q9Y4D8;A0A494C150 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 1 T(0.947)EGT(0.053)PPPPGQPAK 144.28 0.0015847 6936300.0 34934.0 25471.0 31317.0 39916.0 34597.0 25172.0 27814.0 31162.0 23631.0 30829.0 True False 32992.508131882125 27424.543797826456 29302.09831537148 34479.371941059304 30250.615558895744 28639.214511334918 29107.406112395405 31252.676260853197 28357.860305307284 29938.886666638427 1.1019951576438016 0.916017489333905 0.9787303930718128 1.1516584542697923 1.010412173830254 0.9565891621229936 0.9722274056647017 1.0438823797572525 0.9471915445976514 1.0 14.86973295263636 -6.52574367506151 24.8642048510106 0.9857101371151115 1.031376432203024 0.1283744135246303 0.06452578364371532 214.80973872820036 1864249.7629247312 0.021879864238039004 0.02199113500487479 2.9802748984403066e-07 6.52574367506151 0.045666295087912645 T(ph)EMDKSPFNSPSPQDSPR ddPTM_A459_Selumetinib_30min_R2 1 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 T(0.511)EMDKS(0.488)PFNS(0.001)PSPQDSPR 87.15700000000002 0.0096697 52899000.0 101680.0 87249.0 98789.0 98885.0 89729.0 61518.0 73664.0 70078.0 58112.0 76936.0 True False 96029.03265729017 93940.71775024789 92433.02329333077 85416.69241386018 78456.44083256222 69991.54609519707 77089.52196244692 70281.91537796262 69736.02378494428 74714.65777626571 1.285277019468532 1.2573264811244258 1.2371471146949906 1.1432387560368928 1.0500809769818038 0.9367846708846332 1.0317857868437648 0.9406710472852996 0.9333646952351701 1.0 16.189103683162053 -6.114016419227653 1.295169537791095 0.9647036824122293 1.276562963055993 0.9445923669071338 0.03098714329697069 0.09119776193901646 0.31049713557201647 0.011591520228223028 0.019128719010073656 7.691013625764341e-07 6.114016419227653 0.31185928064376367 T(ph)ESGEETDLISPPQEEVK ddPTM_A459_Selumetinib_30min_R1 1 TESGEETDLISPPQEEVK 18 0 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 T(0.57)ES(0.429)GEET(0.001)DLISPPQEEVK 149.44 0.00022993 5328000.0 3744.4 3819.5 3577.0 2681.1 3019.9 3492.9 3242.2 4375.8 2477.6 3137.1 True False 3831.6372346659127 3372.311164362625 3091.263047054557 2212.8962154801557 2746.750578206648 3457.764597299451 2997.6382436898043 4259.739569398416 4204.306243255618 3539.7773429416843 1.0824514830872618 0.9526901942256376 0.8732930768141491 0.6251512457111661 0.7759670487986111 0.9768311004629241 0.8468437286506437 1.203391952856113 1.1877318361955744 1.0 11.789442900242554 -7.757133121328244 24.999713011616603 1.1466714499940183 0.869369831789973 0.4580899890767559 0.12617422125153488 95.06923105233143 551928.528588823 0.06653801827667612 0.036690447958194684 1.7493104022389982e-08 7.757133121328244 -0.2773016182040453 T(ph)ESGEETDLISPPQEEVK ddPTM_A459_Selumetinib_30min_R2 1 TESGEETDLISPPQEEVK 18 0 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 T(0.842)ES(0.158)GEET(0.001)DLISPPQEEVK 104.35 0.0024886 3336900.0 8811.8 5228.1 8528.2 8220.7 7214.8 8298.5 8949.2 6027.8 6318.9 6580.2 True False 8322.075432430272 5629.0784590089315 7979.504896802092 7101.0264785015115 6308.412322869638 9441.54304871734 9365.355532503385 6045.3399000439895 7582.856564817661 6390.212528587179 1.3023159081487095 0.8808906486015532 1.2487072786867532 1.1112347901942923 0.9871991416010656 1.4775006318615798 1.4655780994147913 0.946031117587972 1.1866360517580727 1.0 12.64164819843842 T(ph)ESPATAAETASEELDNR ddPTM_A459_Selumetinib_30min_R2 2 TESPATAAETASEELDNR 18 0 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64 C9JR83 SMC4 Structural maintenance of chromosomes protein 4 1 T(0.692)ES(0.3)PAT(0.008)AAETASEELDNR;T(0.988)ES(0.012)PATAAETASEELDNR 159.54 3.5821e-05 9894500.0 30735.0 25388.0 30277.0 30879.0 29497.0 19166.1 26143.0 25472.0 24694.1 27261.0 True False 29026.871741953342 27335.177964713515 28329.01078310511 26673.226930753855 25791.323153474215 21806.05630246686 27358.701301371748 25546.11930288341 29633.610010803135 26473.904097415747 1.0964333645367705 1.03253293749681 1.070073030364662 1.0075290305730753 0.974216838535418 0.8236811700392712 1.0334214855768995 0.9649547421824005 1.119351717138532 1.0 14.692283343806817 -5.908672002771609 3.3941496770726207 0.9790193345554588 1.06325450628158 0.2020402910548288 0.07043640421251719 0.3867744041755542 8.82429641681949 0.02117145152505344 0.03291635721039671 1.2340364769718652e-06 5.908672002771609 0.08423517172612116 T(ph)ESPQGLPTVQR ddPTM_A459_Selumetinib_30min_R2 2 TESPQGLPTVQR 12 0 F5H212;P15822;A0A0D9SFF3;P15822-2;P15822-3 F5H212 HIVEP1 Zinc finger protein 40 1 T(0.5)ES(0.5)PQGLPT(0.001)VQR;T(0.5)ES(0.5)PQGLPTVQR 157.33 0.0010377 15185500.0 88935.0 85257.0 105141.0 98068.0 95273.0 74930.0 71501.0 74699.0 64485.0 81973.0 True False 83992.34873501277 91795.93775553722 98376.3425288654 84710.96922326415 83303.95398857341 85250.92735318303 74825.93817654363 74916.36172291481 77383.8018614422 79606.2264985681 1.055097728272845 1.153125098288491 1.2357870339531158 1.0641249177259755 1.0464502294939433 1.070907780746478 0.93995082379504 0.9410867091440687 0.9720822762882013 1.0 16.280593656892385 -6.685379157282568 1.128951696030292 0.9594570352865356 1.1415491066606307 0.6406440427269778 0.053053394906405385 0.30097344958723665 0.8162481654993399 0.02806430867213211 0.027301005842982857 2.0635777792707638e-07 6.685379157282568 0.1820920713740951 T(ph)ESVPSDINNPVDR ddPTM_A459_Selumetinib_30min_R2 1 TESVPSDINNPVDR 14 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 T(0.965)ES(0.034)VPS(0.001)DINNPVDR 204.67 4.9147e-05 50482000.0 24743.0 23690.0 23572.0 24321.0 28231.0 18333.0 21209.0 26196.0 18361.0 22167.0 True False 23367.883114076823 25506.946824644052 22055.403183253075 21008.437843934847 24684.369391657812 20858.204339595708 22195.260524836205 26272.226023018753 22033.713049204314 21526.981113217233 1.0855160317732293 1.1848826684287461 1.0245469658405284 0.9759119373703539 1.1466712058618378 0.9689330905200216 1.0310438053577637 1.2204324370818542 1.0235393868430513 1.0 14.393858393510406 -5.270268199128329 24.889535930796352 1.054151034172382 1.1351993518749712 0.1635962649823266 0.07733664194799002 1022.1159733307205 2881472.1578655816 0.02030334051675422 0.04319250188602099 5.367002540610226e-06 5.270268199128329 0.08104831770258913 T(ph)ETEMFEKY(ph)Y(ph)AK ddPTM_A459_Selumetinib_30min_R2 2 TETEMFEKYYAK 12 1 A0A087WWI8;Q9H0I3-2;Q9H0I3 A0A087WWI8 CCDC113 Coiled-coil domain-containing protein 113 3 T(0.5)ET(0.5)EMFEKY(1)Y(1)AK;T(0.5)ET(0.5)EMFEKY(1)Y(1)AK 93.598 0.0058609 10086900.0 58395.0 58795.0 68187.0 62825.0 62675.0 48662.0 42750.0 50846.0 38186.0 59105.0 True False 55149.63967370638 63304.38744427801 63799.92265639223 54268.12662083004 54801.20617839093 55364.74879034559 44737.95970751793 50993.95344199158 45824.26700598639 57398.4850767675 0.960820474616126 1.1028930007405537 1.1115262462251945 0.9454626990285411 0.9547500444497299 0.9645681191114732 0.7794275345017073 0.8884198489522818 0.7983532482555734 1.0 15.808725039776604 -6.445380448095482 1.161475938627946 0.8635270528847163 1.0564797820021394 0.4695974170525624 0.07576269122565163 0.37791395583547516 1.0676134568097595 0.03336756274022842 0.04096239697975385 3.5860765164294926e-07 6.445380448095482 0.19295272911742312 T(ph)ETPPPLASLNVSK ddPTM_A459_Selumetinib_30min_R1 1 TETPPPLASLNVSK 14 0 K7ELG9;Q3MHD2;Q3MHD2-2 K7ELG9 LSM12 Protein LSM12 homolog 1 T(0.873)ET(0.127)PPPLASLNVSK 123.63 0.0037431 90294000.0 2892.7 3260.6 2304.9 2409.2 2129.5 2763.1 2442.8 2218.6 1938.1 3305.3 True False 2960.0942817856203 2878.8474361881854 1991.9072399094355 1988.4784462850296 1936.8871009937604 2735.305722694069 2258.5376292904366 2159.755520971554 3288.8141467766045 3729.567451348428 0.7936829995433909 0.7718984771671942 0.5340853238059174 0.5331659695727164 0.5193329055607983 0.7334109808645818 0.6055762923590134 0.5790900819318048 0.8818218706803469 1.0 11.86479260361969 -8.415941204272885 3.7123597049044497 0.9960457824044804 0.6306348764685591 0.627690520677195 0.09636628195678364 0.14915630574386388 3.5428827527828006 0.10002963679499577 0.02643701732032398 3.837591961263332e-09 8.415941204272885 -0.3654109059359213 T(ph)ETPPPLASLNVSK ddPTM_A459_Selumetinib_30min_R2 2 TETPPPLASLNVSK 14 0 K7ELG9;Q3MHD2;Q3MHD2-2 K7ELG9 LSM12 Protein LSM12 homolog 1 T(0.964)ET(0.036)PPPLASLNVSK;T(0.699)ET(0.301)PPPLASLNVSK 132.51 0.0018761 117206000.0 112631.0 87184.0 92105.0 103689.0 89556.0 87312.0 114815.0 107919.0 82216.0 72149.0 True False 106371.41991761654 93870.73245925545 86179.06457634145 89566.37932649827 78305.17463920193 99338.43546057826 120154.12500160628 108233.02642304766 98661.49730697571 70065.87090438518 1.5181631020154651 1.3397497418872504 1.229972074334807 1.278316792047362 1.117593681894862 1.4177863513056113 1.7148737816386186 1.5447324785379029 1.4081248978067127 1.0 16.096424257923218 -6.986810647264294 24.773930889297485 1.4771847355084444 1.291740207685072 0.053501284454277154 0.19530183268612758 374.0937030748286 702667.4712774018 0.06720528115929962 0.0592383247243503 1.0308354675513119e-07 6.986810647264294 -0.1854445278233725 T(ph)EWLDGK ddPTM_A459_Selumetinib_30min_R1 1 TEWLDGK 7 0 P62937;P62937-2;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284;P0DN37 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 1 T(1)EWLDGK 101.46 0.030912 0.0 1766.9 2322.1 2436.5 2586.2 3250.6 2329.1 2688.8 4362.2 1298.5 2303.8 True False 1808.0653322110893 2050.2274524849977 2105.6366827364923 2134.5687189865266 2956.5838039400405 2305.6713686535973 2485.9816512347024 4246.500285577441 2203.459661312327 2599.5151709123265 0.695539442293976 0.7886960904965403 0.8100113076076019 0.8211410892583396 1.1373597034643952 0.8869620744872969 0.9563251174880513 1.6335739575957497 0.8476425473366253 1.0 11.344026859552844 -6.2499736881451025 0.776642221990395 1.1457419349272326 0.7137314620990788 0.3136516432180725 0.21052404179048828 0.8131768825582836 1.0540534374418356 0.11736716367538914 0.206786331202186 5.623753958318014e-07 6.2499736881451025 -0.43201047282815386 T(ph)FCGTPDYIAPEIIAYQPYGK ddPTM_A459_Selumetinib_30min_R1 2 TFCGTPDYIAPEIIAYQPYGK 21 0 P17252;P05129-2;P05771;P05129;P05771-2 P17252;P05771-2 PRKCA;PRKCG;PRKCB Protein kinase C alpha type;Protein kinase C gamma type;Protein kinase C beta type 1 T(0.954)FCGT(0.046)PDYIAPEIIAYQPYGK;T(0.747)FCGT(0.252)PDYIAPEIIAYQPYGK 154.95 3.736e-07 36685000.0 10668.0 8240.7 6810.799999999999 6337.8 5787.0 8515.0 6360.7 7897.799999999999 6656.2 6022.2 True False 10916.543643685483 7275.875013002503 5885.930769046459 5231.022205240433 5263.566871777832 8429.346831001412 5880.907277971048 7688.32468833009 11295.085250386684 6795.208031195507 1.6065061722275034 1.0707361687236572 0.8661884583996945 0.7698104577852225 0.7745998132233477 1.240483998768527 0.8654491887478531 1.131433306093714 1.6622133124597653 1.0 12.730302003569394 -8.01103404067191 23.90071639645768 1.3530122812157712 1.0107151198712474 0.15227050488438998 0.2805996848541357 469.98774279068766 1018026.6642510719 0.16999536738082197 0.07275018752235084 9.749132195194212e-09 8.01103404067191 -0.3422971613445238 T(ph)FEEALAR ddPTM_A459_Selumetinib_30min_R2 2 TFEEALAR 8 0 E7EXA6;A0A0D9SF58;Q8WVB6;Q8WVB6-2;F8WCC1 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 T(1)FEEALAR;T(1)FEEALAR 145.9 0.004504600000000001 2975300.0 1799.08 3837.6 5193.0 3599.56 4978.0 4564.8 5016.9 5592.200000000001 4222.3 5147.5 True False 1699.0943358878608 4131.931580171124 4858.888033710893 3109.293718412654 4352.619136115355 5193.559764871353 5250.195790798753 5608.472376161452 5066.877980919087 4998.878300188823 0.33989511923578547 0.8265717491092047 0.971995664212781 0.6219982827537942 0.8707191643275138 1.0389450298630347 1.0502747767635063 1.1219461725942803 1.0136029878398312 1.0 12.287388689088749 -4.514361543527825 0.4535495392748326 1.060150649877467 4.205622433406242e-14 0.6414700021349619 0.13580602826935032 4.597223744855755 0.6134280327428073 0.1006999683817986 2.7569591487377076 3.059415456588103e-05 4.514361543527825 -1.0601506498774251 T(ph)FGHNTMDAVPR ddPTM_A459_Selumetinib_30min_R2 1 TFGHNTMDAVPR 12 0 G3XAL9;P55011-3;P55011 G3XAL9 SLC12A2 Solute carrier family 12 member 2 1 T(0.695)FGHNT(0.305)MDAVPR 93.839 0.025368 0.0 32122.0 6516.1 19370.0 27798.0 12613.0 9651.0 33677.0 22854.0 19732.0 12390.0 True False 30336.78783455425 7015.863917436178 18123.7552884614 24011.864445775303 11028.44217834933 10980.337646944756 35243.047229709504 22920.501356316614 23678.951358144943 12032.26850691395 2.5212858088333223 0.583087379857318 1.5062625371140261 1.9956223909047301 0.9165721469739639 0.912574186707624 2.9290442786793065 1.9049193710351542 1.967954034980071 1.0 13.554621046597097 -7.2329013252835 24.998215591784163 2.0258899182172296 1.3776254038514926 0.1282041920514223 0.6821062717020746 1254.8815326469107 1099228.5147049695 0.2515714909018695 0.1948318652723141 5.849229676003852e-08 7.2329013252835 -0.6482645143657371 T(ph)FPASNYTVSSR ddPTM_A459_Selumetinib_30min_R2 2 TFPASNYTVSSR 12 0 O95835;O95835-2;Q6PJG3 O95835 LATS1 Serine/threonine-protein kinase LATS1 1 T(1)FPASNYTVSSR;T(1)FPASNYTVSSR 138.31 0.0029277 18095700.0 25104.0 23316.0 23544.0 27589.0 26488.0 20240.3 18223.0 23097.0 14629.4 23277.0 True False 23708.820179274335 25104.262227243587 22029.204672768985 23831.33060632041 23160.340634275533 23028.217601850145 19070.40560818946 23164.20844608581 17555.68877958879 22604.932529090893 1.0488339281155925 1.1105656783065483 0.9745308748176537 1.0542535606178534 1.0245702173395064 1.018725341126965 0.8436391298070562 1.0247413221107902 0.7766308860686004 1.0 14.464349991075343 -7.110162887392708 5.974399450413532 0.9137536161732492 1.041220385587209 0.4243501638438998 0.0730045376457544 0.2253449230155163 10.526249791187865 0.026198462182803244 0.02027297892892775 7.759560303598844e-08 7.110162887392708 0.12746676941395985 T(ph)FSLDAVPPDHSPR ddPTM_A459_Selumetinib_30min_R1 1 TFSLDAVPPDHSPR 14 0 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 T(0.892)FS(0.108)LDAVPPDHSPR 101.78 0.010911 15598000.0 3359.4 3652.8 3709.8 4270.1 3900.6 3972.5 3347.4 3413.6 2048.2 2969.2 True False 3437.6674837455034 3225.1284778593526 3206.0295364727417 3524.407194704345 3547.7914187068645 3932.5402567414108 3094.9029229927996 3323.0602390645 3475.645805390765 3350.325742457192 1.0260696266579301 0.9626313158116926 0.9569306935872388 1.051959560242485 1.0589392469356866 1.1737784797776742 0.923761795389764 0.9918618350904903 1.0374053368439513 1.0 11.710085656107442 -5.765786405237059 24.976202947990814 1.0358941740410157 0.9799526203256886 0.12796724750021338 0.062097718209063776 224.56967145063066 1290299.9001897594 0.0183166185522974 0.028281274907464796 1.7148004735180962e-06 5.765786405237059 -0.05594155371532705 T(ph)FSPTYGLLR ddPTM_A459_Selumetinib_30min_R2 4 TFSPTYGLLR 10 0 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 T(0.999)FSPTYGLLR;T(0.996)FS(0.004)PTYGLLR;T(0.886)FS(0.087)PT(0.027)YGLLR;T(0.998)FS(0.002)PTYGLLR 185.33 0.00013497 136165500.0 147113.0 148119.0 165195.0 174357.0 163025.0 115950.0 132408.0 142389.0 115589.90000000001 136139.0 True False 138937.0483999992 159479.25102234905 154566.53355071647 150609.2758173985 142544.34203800838 131921.0600106977 138565.23436147452 142803.32841623202 138711.10985165404 132208.31333839873 1.0508949467071538 1.2062724876774427 1.1691135727228432 1.1391815840801245 1.07817986962101 0.9978272672841246 1.048082611921723 1.0801387961944149 1.0491859879991876 1.0 17.012453371668123 -6.365144829530385 3.1977056490583133 1.0406781290067177 1.148901134438032 0.5678781428164034 0.043267963078141375 0.1887337989515345 3.6746000999057893 0.01405420003568773 0.016320046204570882 4.3137519683794723e-07 6.365144829530385 0.10822300543131425 T(ph)FWSPELK ddPTM_A459_Selumetinib_30min_R1 1 TFWSPELK 8 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EPP6;O15083 X6RM00 ERC1;ERC2 ELKS/Rab6-interacting/CAST family member 1;ERC protein 2 1 T(0.987)FWS(0.013)PELK 116.52 0.021778 46203000.0 6178.9 8723.2 6372.1 6609.9 6128.6 6048.5 6457.5 6273.5 4007.7 6265.2 True False 6322.85634795353 7701.88368869434 5506.803819439851 5455.605048190024 5574.269212092214 5987.657581598598 5970.4055760369265 6107.106400800072 6800.774189173205 7069.399448215953 0.8943979462851229 1.0894678883420574 0.778963455068246 0.7717211466338644 0.7885067540636633 0.8469824948298337 0.8445421170172566 0.8638790954642226 0.9620016861389069 1.0 12.787371946672591 -9.947241830669803 11.637682431278357 0.9999999999979605 0.8678073736161175 0.151475440027671 0.09116895475183265 0.0 0.0 0.0942599169135819 0.022861387864508406 1.1291669791022229e-10 9.947241830669803 -0.13219262638184304 T(ph)FWSPELK ddPTM_A459_Selumetinib_30min_R2 1 TFWSPELK 8 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EPP6;O15083 X6RM00 ERC1;ERC2 ELKS/Rab6-interacting/CAST family member 1;ERC protein 2 1 T(0.98)FWS(0.02)PELK 108.57 0.029981 20333000.0 56479.0 41261.0 55399.0 56806.0 52457.0 40869.0 49706.0 52882.0 43481.0 50013.0 True False 53340.12328335064 44425.58602497418 51834.68865387057 49068.924804184164 45866.88268846993 46498.33377815617 52017.42749057043 53035.877864913615 52178.414960647715 48568.994740620416 1.098234039395094 0.9146902517177092 1.0672382438774033 1.0102931935534922 0.9443654935297521 0.9573666086044713 1.0710007025750923 1.091969849245353 1.0743153165780592 1.0 15.567748005961933 -7.281034578649547 23.688777316563236 1.0669856403558988 0.99605230407897 0.21239955007445965 0.05628532209266623 577.1460551947724 697711.5055345338 0.022807337121814427 0.015407240679295074 5.235587490304289e-08 7.281034578649547 -0.07093333627692877 T(ph)GKT(ph)EPSFT(ph)KENSR ddPTM_A459_Selumetinib_30min_R1 1 TGKTEPSFTKENSR 14 2 H0YCM8;Q5TDG9 H0YCM8 DNAJC16 3 T(1)GKT(1)EPS(0.099)FT(0.879)KENS(0.022)R 98.902 0.0099207 18981000.0 1293.5 1701.6 1182.8 1488.9 1362.1 1155.4 1444.0 1081.0 568.06 1120.8 True False 1323.636033287137 1502.3758809476221 1022.1822566553338 1228.8915651144696 1238.8982954982862 1143.7777250192646 1335.0779174289298 1052.3283684171322 963.9563305391447 1264.6655975165095 1.0466292717113765 1.1879629555021636 0.8082628788690441 0.9717126547347447 0.9796252052172338 0.9044111955487374 1.0556766310799415 0.8321000986218372 0.7622223079619755 1.0 10.304540243034324 -5.254680727019003 24.99850704813187 0.9173413815223267 1.1172961195644204 0.4332605750280566 0.09283616596756605 502.40749341117055 1858262.8194679334 0.023897712787526046 0.06027976118281441 5.563130823238327e-06 5.254680727019003 0.19995473804209374 T(ph)GQYTCHVTNDVGSDSCTTMLLVT(ph)EPPKFVK ddPTM_A459_Selumetinib_30min_R2 1 TGQYTCHVTNDVGSDSCTTMLLVTEPPKFVK 31 1 A0A0A0MTS7;Q8WZ42-5;Q8WZ42-11;Q8WZ42-4;Q8WZ42-7;Q8WZ42-2;Q8WZ42;Q8WZ42-8;Q8WZ42-13;Q8WZ42-12 A0A0A0MTS7 TTN Titin 2 T(0.337)GQY(0.317)T(0.337)CHVT(0.009)NDVGS(0.018)DS(0.018)CT(0.018)T(0.113)MLLVT(0.835)EPPKFVK 46.404 0.0097544 16587000.0 2790.9 5021.1 31716.0 32659.0 59129.0 35159.0 6897.6 16153.0 39241.0 22922.0 True False 2635.7929508578995 5406.202224618836 29675.427089769844 28210.787860082575 51700.68640003313 40001.83310837535 7218.352067335107 16200.002555726902 47090.29648514931 22260.18230149164 0.1184084171081239 0.24286423854923103 1.3331169838524328 1.2673206121134142 2.3225634767855743 1.797012826157082 0.3242719205786293 0.7277569579760966 2.1154497230687017 1.0 14.442177787340777 -5.249436104547041 4.614099434289059 1.3653254946424151 0.15027805488478438 0.4037938582597854 0.5745238323519305 0.19908498397221347 11.717184720360873 0.1613994112691235 0.4173297963633441 5.630719531025331e-06 5.249436104547041 -1.2150474397576307 T(ph)GRDTPENGETAIGAENSEK ddPTM_A459_Selumetinib_30min_R2 2 TGRDTPENGETAIGAENSEK 20 1 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 T(0.551)GRDT(0.449)PENGETAIGAENSEK;T(0.908)GRDT(0.092)PENGETAIGAENSEK 98.015 0.0012495 112215500.0 84367.0 63129.0 81192.0 86218.0 90580.0 78816.0 97651.0 91342.0 70708.0 76048.0 True False 79678.21988785997 67970.7913082716 75968.19511516544 74474.9596656542 79200.53060452567 89672.18857958727 102191.96499178563 91607.79009751792 84851.57574659007 73852.29664356657 1.0788861485569103 0.9203612398991342 1.0286504085554824 1.008431193752752 1.072417977558251 1.2142098845263034 1.3837344217607048 1.2404189749121102 1.148936182121855 1.0 16.172355165871465 -6.647502442578386 3.1547607588799855 1.2251930491931555 1.006528114793226 0.4455598753752721 0.09756661726968749 0.2025945843335451 4.017188294420233 0.033930159131409426 0.03361298201988615 2.2516327529757e-07 6.647502442578386 -0.21866493439992962 T(ph)GSCSELDACPSK ddPTM_A459_Selumetinib_30min_R1 1 TGSCSELDACPSK 13 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 T(0.501)GS(0.458)CS(0.041)ELDACPSK 201.48 0.00022033 36536000.0 3390.6 3527.0 3991.7 4099.5 2855.4 2915.2 2657.0 3093.6 1729.4 2907.8 True False 3469.59438304087 3114.0572003421853 3449.649064838603 3383.5992821457235 2597.1295741618155 2885.875734789819 2456.5803508370277 3011.54767857099 2934.665489621514 3281.044454370544 1.0574664352441694 0.9491054582311673 1.0513874812770267 1.0312567626563458 0.7915557409477603 0.8795600836635002 0.7487190085354432 0.9178625039838858 0.8944302737844247 1.0 11.679939425505758 -6.247741263083077 24.800977886578615 0.8621262217723793 1.019152967226634 0.522997795596911 0.06990331832861074 542.9077366475433 982955.0909447224 0.02000134597796048 0.025682016878579413 5.652736440707662e-07 6.247741263083077 0.15702674545425466 T(ph)GSCSELDACPSK ddPTM_A459_Selumetinib_30min_R2 3 TGSCSELDACPSK 13 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 T(0.697)GS(0.197)CS(0.107)ELDACPSK;T(0.598)GS(0.394)CS(0.008)ELDACPSK;T(0.792)GS(0.205)CS(0.003)ELDACPSK 234.04 3.6396e-13 94867000.0 388090.0 327112.0 338781.0 326403.0 277835.0 263128.0 329290.0 288107.0 201072.0 302627.0 True False 366521.5114473623 352200.4385691421 316984.1992968627 281946.3483234183 242930.8834235859 299371.49356183567 344602.637475756 288945.34367131884 241292.0184210882 293889.37219062465 1.2471410882106566 1.1984116198005803 1.0785834034558355 0.9593621784340681 0.8266065615534213 1.0186536904357846 1.1725590309956406 0.9831772463139669 0.821030092454584 1.0 18.164913662738364 -5.394719119043474 2.317316301090322 0.9733145149575592 1.2356656338414522 0.5371846432522949 0.09412860206798523 0.26741358860734565 2.737451579983451 0.028905249054717825 0.08165961584916781 4.0297757673914984e-06 5.394719119043474 0.26235111888389306 T(ph)GSESSQT(ph)GTSTTSSR ddPTM_A459_Selumetinib_30min_R1 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 T(0.738)GS(0.257)ES(0.044)S(0.281)QT(0.675)GT(0.005)S(0.001)TTSSR 136.36 0.0067455 7876700.0 1288.6 1712.5 1320.1 1741.7 952.45 1368.3 1255.5 1290.6 659.99 1183.7 True False 1318.621872820877 1511.9997038803483 1140.837670790249 1437.544790758192 866.3010656687053 1354.536144316997 1160.7966241911504 1256.3690955403802 1119.954826237599 1335.6394252143944 0.9872588723631112 1.1320418335492342 0.8541509401814219 1.0762970631294744 0.6486039939481782 1.0141480692662015 0.8690943096448516 0.9406499028274118 0.8385158487350177 1.0 10.383314869071095 -5.2667776448291805 24.987680997638275 0.9026133458662277 1.0596503547632512 0.2187959641174937 0.1166702201449621 556.0553345749439 2602828.2069219016 0.028385346578197718 0.06189339048685446 5.410312555591266e-06 5.2667776448291805 0.15703700889702354 T(ph)GSESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R1 3 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 T(0.927)GS(0.035)ES(0.035)S(0.003)QTGTSTTSSR;T(0.59)GS(0.409)ES(0.002)SQTGTSTTSSR;T(0.869)GS(0.061)ES(0.061)S(0.009)QTGTSTTSSR 302.64 7.777499999999996e-88 10895100.0 2759.69 3132.59 3083.13 3060.67 2522.06 2530.2000000000003 2868.62 2460.26 1810.6499999999999 2464.9529999999995 True False 2823.9854075780295 2765.8249064984175 2664.4578804208318 2526.181440391499 2293.940118305859 2504.748485237789 2652.2376838607893 2395.0059127492464 3072.5408053563056 2781.353728225474 1.0153276726077396 0.9944168116520139 0.9579715997219733 0.9082560821931928 0.8247566985193974 0.900550138524034 0.9535779850457706 0.8610936064853857 1.1046925726044243 1.0 11.441571520718266 -10.38096966401417 9.378149401217925 0.9999986947662228 0.9400743350239427 0.03560535424846811 0.0763732089600829 0.0 0.0 0.07481467506168482 0.018145223977975886 4.159396633592568e-11 10.38096966401417 -0.059924359742280164 T(ph)GSESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 2 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 T(0.497)GS(0.449)ES(0.007)S(0.048)QTGTSTTSSR;T(0.928)GS(0.072)ESSQTGTSTTSSR 272.24 2.874e-50 10502400.0 6275.8 9471.8 5702.4 6357.849999999999 5556.47 5803.9 5965.7 6546.56 4258.8 9234.9 True False 5927.016160017915 10198.25660336274 5335.513792303677 5491.899862097005 4858.416563127941 6603.334542441467 6243.11687081029 6565.609405758651 5110.679000814296 8968.264441848234 0.6608877557580628 1.137149408281835 0.5949327015165604 0.6123704199076004 0.5417343115416309 0.7363001598869683 0.6961343425243235 0.7320936451340377 0.5698626566993888 1.0 13.130613103318176 -5.292427190315485 24.958320382346894 0.6703184772407038 0.8990188211195442 0.21069434213024685 0.16328043931612035 754.781764548159 607917.96271553 0.03957985100427166 0.08240576483397281 5.100030926785474e-06 5.292427190315485 0.22870034387884042 T(ph)GSGSPFAGNSPAR ddPTM_A459_Selumetinib_30min_R1 1 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 T(0.589)GS(0.166)GS(0.242)PFAGNS(0.003)PAR 137.73 0.0013672 13889000.0 1694.8 2747.2 2573.1 2726.4 2121.0 1962.5 2309.4 1999.2 1310.8 2258.2 True False 1734.285542493267 2425.556546861368 2223.6871530265807 2250.2854208664708 1929.1559244929647 1942.7590318074306 2135.2000986913927 1946.174721683192 2224.3318629558694 2548.0619667307124 0.6806292645694327 0.9519221190579895 0.8726974390970874 0.8831360658601629 0.7571071464043575 0.7624457557051036 0.8379702403513202 0.7637862607322023 0.8729504588186273 1.0 11.315184647816753 -8.543340700522345 18.45305575648229 1.0000000048110986 0.8197217593685754 0.36997294711054307 0.07369828490397069 119.3486591733448 107633.0146312251 0.07102149840813594 0.018337670305041718 2.861931926479895e-09 8.543340700522345 -0.18027824544252324 T(ph)GSIVLPYIMSSTLR ddPTM_A459_Selumetinib_30min_R1 1 TGSIVLPYIMSSTLR 15 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 T(0.96)GS(0.022)IVLPYIMS(0.016)S(0.003)TLR 141.82 0.00089789 2927600.0 527.74 651.52 570.42 628.61 390.07 413.21 343.15 421.71 257.06 281.74 True False 540.0353151967171 575.2397355165691 492.9600970927764 518.8350639711238 354.7882373724518 409.0534825646616 317.26591922834996 410.5248808928666 436.2120450804365 317.90407337999767 1.6987366958057222 1.8094758252089853 1.550656749539445 1.63204912241231 1.116022936102381 1.2867198529907198 0.9979926204000383 1.291348287954012 1.372149908123457 1.0 8.312447691961443 -6.213601897800361 5.484034437008566 1.188244821657403 1.6790301518828172 0.7793696343285423 0.1290753545630739 0.09890803627204828 7.194018848396683 0.03890888563874448 0.04992952398298219 6.115023103397637e-07 6.213601897800361 0.49078533022541415 T(ph)GSKPRSGGNHR ddPTM_A459_Selumetinib_30min_R1 1 TGSKPRSGGNHR 12 2 A6NGZ8 A6NGZ8 SMIM9 Small integral membrane protein 9 1 T(0.978)GS(0.022)KPRSGGNHR 92.866 0.027263 76207000.0 19749.0 12227.0 16222.0 14102.0 16778.0 14664.0 18146.0 15241.0 9276.7 13754.0 True False 20209.113275135423 10795.457155821916 14019.141501067657 11639.350427325033 15260.432862396487 14516.493473846715 16777.23261057159 14836.759170254869 15741.882356639237 15519.459875305214 1.3021789055489266 0.6956077880648283 0.903326637248189 0.7499842469289626 0.9833095342885679 0.9353736270774194 1.0810448781962936 0.9560100215770609 1.0143318442214566 1.0 13.921790727745988 -6.717651991640722 2.43657891967089 1.0051509921663269 0.8969539515190523 0.05138944300241233 0.15541795570248546 0.7458445101283423 9.069946514028745 0.05633560699900802 0.05352555859481642 1.9157904691447305e-07 6.717651991640722 -0.10819704064727453 T(ph)GSNAAQYK ddPTM_A459_Selumetinib_30min_R1 1 TGSNAAQYK 9 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 T(0.98)GS(0.02)NAAQYK 114.71 0.019639 44508000.0 4116.7 4609.7 5306.5 5142.6 2970.8 4379.6 3265.1 3637.8 2820.4 3204.0 True False 4212.611100296219 4069.994181008612 4585.906446518035 4244.541448557773 2702.0916645373386 4335.545200358639 3018.8108782529075 3541.313726760265 4786.012806134221 3615.2646096028716 1.165228981886049 1.1257804394726425 1.2684843135235366 1.174061073505772 0.7474118650568587 1.1992331595431651 0.8350179597461103 0.9795448215197919 1.3238347183278387 1.0 11.81988552989958 -6.043961448340073 24.99379231944877 1.0086543589949366 1.1872342942009642 0.21829551183357543 0.15679311741621862 665.416864534501 378314.07022267405 0.044974557827666566 0.058065579767882146 9.037296928706528e-07 6.043961448340073 0.17857993520602755 T(ph)GSNAAQYK ddPTM_A459_Selumetinib_30min_R2 2 TGSNAAQYK 9 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 T(0.976)GS(0.024)NAAQYK;T(0.974)GS(0.026)NAAQYK 105.2 0.032466 231540000.0 870430.0 940050.0 789900.0 921420.0 775900.0 754040.0 916990.0 828430.0 683530.0 991400.0 True False 822054.9852073673 1012148.8122628405 739078.6939780937 795921.0064618426 678424.5053659921 857902.1655063961 959631.8519812144 830840.5941460313 820255.0994239218 962775.7060334554 0.8538385213251338 1.0512820441147166 0.7676540749278228 0.8266941110728288 0.70465478212058 0.8910716796551417 0.9967345934961389 0.8629638127960413 0.8519690456288048 1.0 19.876840212814187 -6.991308615814048 24.99438887240489 0.9204123362063361 0.8426863716141857 0.1586780613923735 0.09419073347400353 439.5874850061175 1264144.2749241258 0.035005729548014446 0.030826071414670156 1.0202142473530304e-07 6.991308615814048 -0.07772596459215042 T(ph)GSNISGASSDISLDEQYK ddPTM_A459_Selumetinib_30min_R2 2 TGSNISGASSDISLDEQYK 19 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 T(0.474)GS(0.474)NIS(0.052)GASSDISLDEQYK;T(0.477)GS(0.477)NIS(0.045)GASSDISLDEQYK 256.8 9.561899999999999e-47 17089800.0 103110.0 65776.0 71130.0 64555.0 68659.0 53327.0 85577.0 83604.0 51375.0 69490.0 True False 97379.55898203378 70820.80769682513 66553.57324048819 55762.49763641356 60033.44260075216 60672.31019569195 89556.50006760852 83847.27379861282 61651.435537436526 67483.64314329698 1.4430098086917866 1.0494514581324825 0.9862178468812974 0.8263113109943641 0.8895999060583493 0.899066905247815 1.3270845481391884 1.2424829172392007 0.913575981760852 1.0 16.042250239999063 -4.761934066346505 4.660221967227645 1.0156556857451762 1.4758390149461194 0.4243668694430165 0.15010435152796772 0.21596249155127964 10.935273488035856 0.041978317046486704 0.3317008969820882 1.7300789961475933e-05 4.761934066346505 0.4601833292009432 T(ph)GSPGPELLFHEGQQK ddPTM_A459_Selumetinib_30min_R1 1 TGSPGPELLFHEGQQK 16 0 A6NHN7;A6NHB5;Q14202-2;Q14202;A6NL54;Q14202-3 A6NHN7 ZMYM3 Zinc finger MYM-type protein 3 1 T(0.5)GS(0.5)PGPELLFHEGQQK 140.28 0.00054221 15408000.0 4301.6 5091.0 4563.7 4688.4 3492.6 4548.0 4425.4 3786.4 2316.5 4028.3 True False 4401.818910543449 4494.943353258308 3943.974606609697 3869.6589521678284 3176.6949466686133 4502.251249253604 4091.5885150900185 3685.9723720394372 3930.9313095340817 4545.371543964809 0.9684178439467807 0.9889055954571068 0.8676902577626187 0.8513405152337505 0.6988856501481209 0.9905133619344149 0.9001659106443547 0.8109287296730555 0.8648206800065531 1.0 12.150182511474707 -5.266052223376497 22.297155323107546 0.8644596081455165 0.9786617344240057 0.2067753806341952 0.0813686245570222 112.63672636817256 544472.1597008322 0.02105467441164428 0.04651877042462634 5.419357193806207e-06 5.266052223376497 0.11420212627848925 T(ph)GSQGQCTQVR ddPTM_A459_Selumetinib_30min_R2 1 TGSQGQCTQVR 11 0 P62857 P62857 RPS28 40S ribosomal protein S28 1 T(0.937)GS(0.063)QGQCTQVR 111.72 0.018911 36635000.0 8233.0 9479.1 8251.1 9687.4 9369.1 6008.5 7655.4 5760.1 5399.2 7889.8 True False 7775.4428193102885 10206.116489889546 7720.233209118422 8367.959408302884 8192.069897183283 6836.116335267591 8011.391268887316 5776.860937364109 6479.190866252597 7662.00097383775 1.0148057727817956 1.3320432253583356 1.0076001341528809 1.0921376069874777 1.069181526490988 0.8922103192899375 1.0456003981522026 0.7539624384138638 0.8456264738644759 1.0 12.903505493789947 -6.639166413741844 0.8859434070443508 0.8717520730586229 1.1478940820787678 0.42434115567805997 0.11294157575583336 0.5082006140794474 0.8745370170278921 0.06466097207455618 0.06859295584461737 2.29526897428573e-07 6.639166413741844 0.27614200902014485 T(ph)GSSAQKSLS(ph)EYNNFKS(ph)MVVSGAK ddPTM_A459_Selumetinib_30min_R2 1 TGSSAQKSLSEYNNFKSMVVSGAK 24 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 3 T(0.873)GS(0.056)S(0.071)AQKS(0.094)LS(0.479)EY(0.446)NNFKS(0.849)MVVS(0.133)GAK 47.757 0.046618 0.0 10308.0 8334.0 9946.8 9273.3 9366.5 6000.1 8347.3 7238.4 7271.0 8608.4 True False 9735.12262619342 8973.19100196637 9306.833717256983 8010.26054266523 8189.796532427576 6826.559311515202 8735.465989861155 7259.462545618371 8725.403168714372 8359.85312469072 1.1645088114575672 1.0733670637662478 1.1132771806444024 0.9581819708060452 0.9796579449750278 0.8165884268173379 1.0449305579378023 0.8683720200989704 1.0437268500500332 1.0 13.029261880300574 -5.768019358135644 6.4017096203967725 0.9513700601242832 1.1134814376472983 0.5121366299536445 0.07052308966741772 0.10877882449810215 18.701826032012114 0.0185093335987864 0.02954469176852262 1.7060063442002689e-06 5.768019358135644 0.1621113775230152 T(ph)GSSGALGPPER ddPTM_A459_Selumetinib_30min_R2 1 TGSSGALGPPER 12 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 T(0.91)GS(0.057)S(0.033)GALGPPER 105.66 0.021583 21062000.0 43141.0 43382.0 44321.0 43319.0 44666.0 35446.0 49710.0 34656.0 26892.0 29149.0 True False 40743.39592710619 46709.25990488423 41469.43511305614 37418.87747055689 39054.65776089364 40328.36475324872 52021.61349849629 34756.84322239033 32271.1514252602 28307.392631802642 1.4393199846082614 1.6500728453671694 1.464968379548538 1.3218765132228294 1.3796628417488623 1.4246584020578716 1.8377394970687382 1.2278362643453742 1.14002557017577 1.0 14.788891249584234 -7.986064352649655 24.988661171702223 1.1079853962355997 1.4950611271603813 0.6052903551508229 0.1436744178502221 157.30466519608993 282070.2866792438 0.0814512554853662 0.03910005598733044 1.0326083851453666e-08 7.986064352649655 0.38707573092478165 T(ph)GSYGALAEITASK ddPTM_A459_Selumetinib_30min_R1 1 TGSYGALAEITASK 14 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 T(0.5)GS(0.5)YGALAEITASK 205.28 3.2652e-05 356200000.0 3555.5 3731.0 4275.2 3488.4 2536.9 3137.0 3034.7 3207.3 1627.0 2710.0 True False 3638.336232201326 3294.1727855051577 3694.651321992633 2879.2164253780065 2307.4378429260723 3105.4446281681057 2805.790135749014 3122.2319852213423 2760.900168621605 3057.8548976353873 1.1898328579995145 1.0772822438541845 1.2082493923598778 0.9415804613896099 0.7545936351363154 1.0155631094757045 0.9175681089114814 1.0210530223771368 0.9028878939797259 1.0 11.578304233732103 -5.7727585146880385 24.516974120395172 0.9320214673132009 1.1503375600136398 0.6236971629301684 0.07899830704156001 106.42481953116545 230513.6541590745 0.022079298769707753 0.033097168718712044 1.6874910779150991e-06 5.7727585146880385 0.21831609270043895 T(ph)GSYGALAEITASK ddPTM_A459_Selumetinib_30min_R2 1 TGSYGALAEITASK 14 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 T(0.812)GS(0.188)YGALAEITASK 160.8 0.00067339 66747000.0 63668.0 55263.0 52222.0 47291.0 51029.0 46079.0 60567.0 47977.0 38507.0 48424.0 True False 60129.58744319779 59501.494401448006 48862.09337501452 40849.88421847468 44618.280814951875 52425.96398648504 63383.48551123371 48116.60512698009 46209.47597547578 47025.87329933827 1.2786490334894836 1.2652927043522928 1.0390470170322619 0.8686682745570512 0.9488028118252878 1.114832331826632 1.347842816395408 1.0231942918039794 0.9826394011087088 1.0 15.521167115279331 -5.256050166716994 9.844439414239499 1.0456256316944608 1.272223369421622 0.37318411621011527 0.11978999287457784 0.19492079981255642 280.1450994506964 0.034634405900896496 0.08311701930276533 5.545616501033352e-06 5.256050166716994 0.2265977377271613 T(ph)HPYSPK ddPTM_A459_Selumetinib_30min_R2 1 THPYSPK 7 0 Q15853-3;M0QZ39;M0R1C6;H0YD59;E9PME6;M0QXT0;B1AQP1;B4DLJ1;Q15853-4;P22415-2;P22415;Q15853-2;Q15853 Q15853-3 USF2;USF1 Upstream stimulatory factor 2;Upstream stimulatory factor 1 1 T(1)HPYSPK 101.72 0.026763 7587400.0 119980.0 102940.0 84001.0 101430.0 101640.0 70259.0 129900.0 160030.0 85777.0 132420.0 True False 113311.99191799444 110835.16699573061 78596.46711337351 87615.05902349047 88871.07452687125 79936.53950229933 135940.60739196665 160495.66080560733 102934.79680962891 128596.69053152077 0.8811423641592094 0.8618819546414643 0.6111857683779853 0.6813165926849015 0.6910836830990433 0.6216065061387083 1.0571081326439407 1.2480543639361208 0.8004467018876992 1.0 16.972493989457263 -7.271534869276617 24.66255055717528 1.0470735297007634 0.7222781190113772 0.5555252845019993 0.13167726396006516 431.8680380569313 1055017.5993316069 0.05545969640303701 0.03789329516109843 5.351371861618316e-08 7.271534869276617 -0.3247954106893862 T(ph)HSASFYSVSQPK ddPTM_A459_Selumetinib_30min_R2 1 THSASFYSVSQPK 13 0 Q7Z2Z1-2;Q7Z2Z1 Q7Z2Z1-2 TICRR Treslin 1 T(0.498)HS(0.498)AS(0.005)FYSVSQPK 110.84 0.0073948999999999985 3277600.0 29060.0 18756.0 28708.0 32964.0 32303.0 25624.0 20224.0 25638.0 19449.0 30833.0 True False 27444.961536397062 20194.524889954555 26860.958534907077 28474.246333928226 28244.808347515933 29153.47340848744 21164.456073095735 25712.602335400625 23339.343450464294 29942.771176245176 0.9165805454296184 0.6744374049779233 0.8970765723987822 0.9509556135044043 0.9432930633328853 0.9736397889456565 0.7068302378734524 0.8587248716578204 0.7794650439362255 1.0 14.869920127238924 -12.056886998292061 2.1756107843812362 3.088819812285699 0.8561166796544148 0.16208351083884587 0.09844567170931935 3149097.645267393 395654.9412869433 32326826.58979579 0.02676400957098752 8.772290429814723e-13 12.056886998292061 -2.2327031326312845 T(ph)HSEGSLLQEPR ddPTM_A459_Selumetinib_30min_R1 1 THSEGSLLQEPR 12 0 P49796-1;P49796-4;P49796-6;P49796;C9J582 P49796-1 RGS3 Regulator of G-protein signaling 3 1 T(0.971)HS(0.029)EGSLLQEPR 101.72 0.016634 5906800.0 1718.2 2370.2 2153.2 2206.1 2196.1 1765.4 2002.3 1785.4 911.26 1698.3 True False 1758.2307169647927 2092.695882123915 1860.8072666809828 1820.8460486258523 1997.4631427529466 1747.6416788549495 1851.2648989390223 1738.0453922034676 1546.341664202904 1916.2933478428688 0.9175164746796184 1.0920540346704324 0.9710451005717128 0.9501917076921133 1.0423577084382456 0.9119906828577332 0.9660655040226238 0.9069829492232746 0.8069441278098619 1.0 10.904102711646264 -7.215781772076252 1.3251344012514648 0.8985741533061995 0.9953554179528206 0.21333532446775016 0.06655087755324303 0.6043726417215652 2.0837124338043918 0.03917659380831688 0.023636322532040045 6.08440658828911e-08 7.215781772076252 0.09678126464662107 T(ph)HSEGSLLQEPR ddPTM_A459_Selumetinib_30min_R2 1 THSEGSLLQEPR 12 0 P49796-1;P49796-4;P49796-6;P49796;C9J582 P49796-1 RGS3 Regulator of G-protein signaling 3 1 T(0.722)HS(0.275)EGS(0.003)LLQEPR 118.51 0.006106899999999999 8325100.0 29061.0 19790.0 22679.0 29821.0 33528.0 26078.0 27766.0 30862.0 23844.0 29035.0 True False 27445.90596040037 21307.82936512055 21219.857831028185 25759.328355905636 29315.912895877 29670.007787485767 29057.174017285226 30951.803310520856 28613.46625702454 28196.684108010228 0.9733735305635965 0.7556856431592726 0.7525657183569313 0.9135587807854265 1.039693631477356 1.0522516645514708 1.0305174149548508 1.0977107518017675 1.014781246880583 1.0 14.783237893159185 -6.0962069130121606 3.217865082348062 1.0445198632284347 0.8205314007885551 0.7011125258832965 0.06243409811105308 0.13142480213542812 2.5928502234088113 0.018977638010438884 0.02608920471151513 8.012962070180356e-07 6.0962069130121606 -0.22398846243987958 T(ph)HSFENVSCHLPDSR ddPTM_A459_Selumetinib_30min_R2 1 THSFENVSCHLPDSR 15 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 T(0.901)HS(0.085)FENVS(0.013)CHLPDSR 67.655 0.046691 8211500.0 49635.0 36095.0 77381.0 110040.0 113630.0 91015.0 74280.0 89470.0 87543.0 96238.0 True False 46876.48540464794 38863.37043628225 72402.39070606262 95052.36217041186 99354.78353491126 103551.490098091 77734.16718302769 89730.34288744412 105054.04615579177 93459.35888364702 0.5015708000202227 0.4158317679523729 0.7746938516473301 1.0170448771080065 1.0630800887325131 1.1079841691082888 0.8317429962236684 0.9601001329268118 1.1240612755174113 1.0 16.512051520127343 -5.481563543955534 2.7225545226792973 1.0115815833466044 0.45558982956700994 0.8799568435643891 0.08175103487143306 0.08837718173629452 1.2879268531094095 0.02415429905963645 0.056301608985679256 3.2994112892231338e-06 5.481563543955534 -0.5559917537795944 T(ph)HSQGGYGSQGYK ddPTM_A459_Selumetinib_30min_R2 1 THSQGGYGSQGYK 13 0 K7ERS0;K7EPH2;K7ER00;Q9Y285-2;Q9Y285 K7ERS0 FARSA Phenylalanine--tRNA ligase alpha subunit 1 T(0.568)HS(0.432)QGGYGSQGYK 100.58 0.015305 0.0 32349.0 29195.0 36635.0 34670.0 35226.0 26189.0 29260.0 29364.0 22505.0 30722.0 True False 30551.172083307247 31434.16262327912 34277.94398517208 29947.88619091407 30800.594955564386 29796.297029928082 30620.64797759006 29449.444378528126 27006.628842238624 29834.976034657804 1.0240052496713077 1.0536010683153767 1.1489181001973356 1.0037844895911798 1.0323653325474393 0.998703568433077 1.0263339223741819 0.9870778627178441 0.905200286095969 1.0 14.864716997578705 -6.986252099179055 0.7807709957277658 0.961990094182181 1.0667116610730454 0.4270323364207137 0.043678654634362726 0.6380376313694255 0.8151508561542506 0.033416666591118485 0.025890218518473996 1.0321620825794372e-07 6.986252099179055 0.10472156689086443 T(ph)HT(ph)GERPYPCPQCGK ddPTM_A459_Selumetinib_30min_R2 1 THTGERPYPCPQCGK 15 1 Q9NW07 Q9NW07 ZNF358 Zinc finger protein 358 2 T(1)HT(1)GERPYPCPQCGK 107.11 0.011901 0.0 46393.0 45697.0 45371.0 40879.0 43920.0 35165.0 36362.0 42086.0 29541.0 40250.0 True False 43814.66278589365 49201.81296098605 42451.8792562097 35311.209679791646 38402.37695021824 40008.65955391279 38052.905049936075 42208.46329228764 35450.025444504354 39087.877917940816 1.1209271293232141 1.2587486346605445 1.0860625216168323 0.9033800646308371 0.9824625688516097 1.0235567056852004 0.9735218967328564 1.0798351187265276 0.9069314409681285 1.0 15.254433642345838 -5.520705343529448 6.079094780746615 0.986334401338221 1.1869645060332032 0.6792039951112339 0.05766723007124896 0.07785686586436234 12.031734422565386 0.014807433151437857 0.02806466951444013 3.0150509568299726e-06 5.520705343529448 0.20063010469498221 T(ph)IAPALVSK ddPTM_A459_Selumetinib_30min_R2 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 T(1)IAPALVSK 110.38 0.025454 5991800.0 89411.0 77408.0 67242.0 67620.0 72942.0 60619.0 52578.0 77653.0 64661.0 78996.0 True False 84441.89456059184 83344.94469405014 62915.72292755399 58410.03934899365 63778.37385024642 68968.71700550657 55022.98118133052 77878.9573738538 77595.00677929306 76715.18022374286 1.1007194966408695 1.086420503099534 0.8201209036341671 0.7613882829791764 0.8313657566108071 0.89902307215282 0.7172372015662847 1.0151701025366393 1.0114687412971481 1.0 16.227224462708776 -5.251575871016821 23.568461579809988 0.8711252362394115 1.0935700990315862 0.41947330587999787 0.09891432515701046 294.81364670560106 704436.0918394557 0.026302172467181188 0.06756209565602898 5.603045239087991e-06 5.251575871016821 0.22244486279217468 T(ph)IAQDYGVLK ddPTM_A459_Selumetinib_30min_R1 1 TIAQDYGVLK 10 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 T(1)IAQDYGVLK 100.38 0.040906 4649200.0 881.1 1154.1 1300.0 1336.5 1319.4 1153.9 1400.6 1511.3 674.85 1174.1 True False 901.6279156778485 1018.9774354734666 1123.4671403888517 1103.1053642121624 1200.0605029589892 1142.2928136573732 1294.9516143704705 1471.2154146057464 1145.1711609061406 1324.807171702474 0.680572942943229 0.7691515091694485 0.8480231420736607 0.8326535270748809 0.9058378672700147 0.8622332653811373 0.9774642242511135 1.110512870122168 0.8644059191153924 1.0 10.371566672508996 -4.3450902525432324 0.3246769324578641 1.0131328483542306 0.3378002287607982 0.6893002543576123 0.06436175603748472 5.36576568333423 0.36771295123897496 0.06591747295617935 1.507432107045522 4.5176205206752e-05 4.3450902525432324 -0.6753326195934324 T(ph)IELMNT(ph)SVMEDQNEDES(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TIELMNTSVMEDQNEDESPK 20 0 Q9UKB1-3 Q9UKB1-3 FBXW11 F-box/WD repeat-containing protein 11 3 T(0.667)IELMNT(0.667)S(0.667)VMEDQNEDES(1)PK 50.787 0.043826 0.0 1164.6 902.23 1102.7 1085.3 1003.4 971.84 1195.4 1372.0 716.81 853.83 True False 1191.7329140828765 796.5964921646525 952.9593966975289 895.77272860416 912.6426471646585 962.0641719601196 1105.2300155779385 1335.6101031159174 1216.3742162689941 963.4273975084956 1.2369722068988263 0.8268360379045875 0.9891346241159035 0.9297770967700355 0.9472874131717961 0.998585025138478 1.1471855776949633 1.3863111082058883 1.2625489158961436 1.0 9.912032140985913 -7.369381331058713 3.312895253244717 1.246214447830605 0.9750685929437751 0.3742136427311631 0.1326761110714017 0.22187900647712 4.581181153174528 0.057942042943496364 0.037039771146335894 4.271876305219395e-08 7.369381331058713 -0.27114585488682985 T(ph)IHTFPCLK ddPTM_A459_Selumetinib_30min_R2 1 TIHTFPCLK 9 0 Q86X02 Q86X02 CDR2L Cerebellar degeneration-related protein 2-like 1 T(0.969)IHT(0.031)FPCLK 86.014 0.046646 10750000.0 91587.0 74947.0 93106.0 107640.0 92637.0 81971.0 87825.0 77361.0 79544.0 70626.0 True False 86496.96119181007 80695.19390741238 87115.66132614795 92979.24631064314 80999.11187471231 93261.76119134891 91909.03652193607 77586.10770219695 95455.02264505802 68586.84387161447 1.2611305070943486 1.1765404172622835 1.270151189479093 1.3556425848182783 1.1809715581363092 1.3597616674988373 1.34003886654965 1.1312097673925325 1.3917395415327354 1.0 16.06564424892955 -10.76503434339572 5.910977499569426 0.9999910162756168 1.2710551279538005 0.48736191170248977 0.08429204710472725 9.548893885676235e-06 1.2242825865533169e-06 0.07809456912808084 0.018940087723878434 1.717772542754077e-11 10.76503434339572 0.2710641116781837 T(ph)IPIDGNFFTYTR ddPTM_A459_Selumetinib_30min_R1 2 TIPIDGNFFTYTR 13 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 T(1)IPIDGNFFTYTR;T(1)IPIDGNFFTYTR 194.67 0.00034649 72145000.0 576.85 767.55 931.81 1085.26 1090.35 837.0699999999999 971.28 815.1 340.04999999999995 684.25 True False 590.2894826452922 677.6848891756856 805.275320065951 895.7397138532666 991.7280350169275 828.64983579875 898.0155676179858 793.480900182058 577.0400137306555 772.0801526594147 0.7645443036089606 0.8777390363441069 1.042994457624893 1.160164149755578 1.284488445404198 1.0732691844810183 1.1631118408170305 1.0277182977038444 0.7473835608169083 1.0 9.592606816855826 -5.139765111028514 2.495994759978722 1.0811393791310175 0.7728565062549926 0.3560780493326626 0.13267816277920078 0.348458137744949 3.948466581864067 0.03790974657375521 0.16034386239278808 7.248278785754074e-06 5.139765111028514 -0.30828287287602496 T(ph)IPIDGNFFTYTR ddPTM_A459_Selumetinib_30min_R2 1 TIPIDGNFFTYTR 13 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 T(1)IPIDGNFFTYTR 150.26 0.0011627 3036700.0 3530.3 3404.3 3077.1 3277.5 2859.1 2280.5 2895.1 1196.4 2588.4 3695.6 True False 3334.1000589106166 3665.3988634502193 2879.1227360931643 2831.098845997142 2499.9142973216976 2594.6181746821594 3029.7278865318194 1199.8813259253182 3106.152325938698 3588.8984256780623 0.92900373971456 1.0213158548107149 0.8022302095521698 0.7888489754240545 0.6965686962426029 0.7229567034045968 0.8441943814443295 0.334331369575783 0.8654890602962224 1.0 11.809325376708736 -5.513798509423862 1.8475767650303163 0.7180767563134902 0.9811702882463772 0.20248622962398044 0.16598767067483597 0.4906806069381651 3.2424824221168276 0.047523312009898074 0.1321991065053685 3.06338435876e-06 5.513798509423862 0.263093531932887 T(ph)ISAQDTLAYATALLNEK ddPTM_A459_Selumetinib_30min_R1 1 TISAQDTLAYATALLNEK 18 0 Q9UPU5;A0A0U1RQI9 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 T(0.852)IS(0.148)AQDTLAYATALLNEK 278.32 1.6832999999999994e-66 167420000.0 2938.6 3669.2 2607.0 3120.6 3002.8 2729.4 3058.1 3029.4 1474.3 2626.8 True False 3007.0636624797703 3239.608358235197 2252.9837192259524 2575.6457909169258 2731.197270187399 2701.944714096917 2827.4250549095646 2949.050471121983 2501.779421388343 2963.9753671987587 1.0145373324481215 1.0929943595641074 0.7601222817702559 0.8689835345531762 0.9214642268665825 0.9115948614142884 0.9539300110924176 0.9949645681128311 0.8440621501361413 1.0 11.53331774250561 -5.228255601298079 24.999272351180284 0.9077250412315468 1.0537658863884865 0.41382965663657145 0.06991585129723057 631.1540184821558 475483.23206362576 0.0179309743635037 0.047434709798806644 5.912135767131881e-06 5.228255601298079 0.1460408451569396 T(ph)ISDGTISASK ddPTM_A459_Selumetinib_30min_R2 3 TISDGTISASK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 1 T(0.757)IS(0.229)DGT(0.013)IS(0.001)ASK;T(0.981)IS(0.019)DGTISASK;T(0.648)IS(0.351)DGTISASK 171.49 0.00070757 71558000.0 302478.0 290931.0 289314.0 312999.0 326030.0 218313.0 237202.0 281107.0 209492.0 270954.0 True False 285667.4836753718 313244.4722093922 270699.85222126555 270367.9962466084 285071.1966548195 248383.63410190106 248232.36300684614 281924.97483023064 251396.25369554598 263130.853996962 1.0856479935213905 1.1904513189966264 1.028765149009819 1.0275039667135726 1.0833818699881952 0.943954805485368 0.9433799162515244 1.071424998428674 0.9554039363945076 1.0 18.005420899294002 -5.616177352850807 1.0196795380202628 0.9930113779234342 1.1457818414431997 0.4693585446786882 0.053874208210641025 0.61248382893662 1.1202653682652848 0.020233909882697843 0.0762872571543003 2.4200405728758866e-06 5.616177352850807 0.15277046351976553 T(ph)ISNPEVVMK ddPTM_A459_Selumetinib_30min_R2 3 TISNPEVVMK 10 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6;F8W9I4;E9PFY5 A8MQ02 MLLT4 Afadin 1 T(0.601)IS(0.399)NPEVVMK;T(0.944)IS(0.056)NPEVVMK;T(0.929)IS(0.071)NPEVVMK 137.84 0.003982 49945000.0 198669.0 163413.0 180465.0 194849.0 171885.0 123811.0 147532.0 157267.0 129700.0 159975.0 True False 187627.7723150195 175946.25164438828 168854.07837543593 168310.23006672683 150291.26962860365 140864.84140564466 154392.53032911202 157724.62093304662 155643.62412078868 155356.10608503275 1.2077270539487077 1.1325351547372442 1.0868840796190862 1.0833834234658517 0.9673985362786004 0.9067222715310821 0.9937976319038705 1.0152457145567069 1.0018507031554882 1.0 17.245219420405583 -5.6061589087392365 1.1303887728542812 0.979800331370321 1.1923477577494266 0.8128009275805588 0.03609840185578953 0.27795931910148314 0.6429057311518211 0.014200659896986649 0.050299555851835605 2.4765157325100017e-06 5.6061589087392365 0.21254742637910562 T(ph)ISPSTSNNIPLMR ddPTM_A459_Selumetinib_30min_R1 2 TISPSTSNNIPLMR 14 0 O94806;O94806-2;Q15139;F8WBA3 O94806;Q15139 PRKD3;PRKD1 Serine/threonine-protein kinase D3;Serine/threonine-protein kinase D1;Serine/threonine-protein kinase 1 T(0.857)IS(0.142)PS(0.001)TSNNIPLMR;T(0.936)IS(0.064)PSTSNNIPLMR 204.17 6.281800000000001e-05 72568000.0 2410.11 2262.19 2616.7 2810.7 2608.34 2345.13 2596.54 2007.98 1280.73 1975.65 True False 2466.2608737422975 1997.3317431364017 2261.366512504239 2319.864008373456 2372.4161075398288 2321.540121407675 2400.6808973136535 1954.7218475617328 2173.3052691817747 2229.243921960645 1.1063216768011612 0.895968235445373 1.0144096346869669 1.040650592570915 1.0642245490360078 1.0414024676877238 1.0769036414831752 0.8768541783630986 0.9749068945628563 1.0 11.12233876835249 -7.752932995251257 24.997155334961953 0.9444103950966378 1.0298576073986383 0.2851338508120651 0.06019971018731843 227.61275558360182 668876.1004158317 0.02879264866486442 0.016280293059337425 1.7663103133248987e-08 7.752932995251257 0.08544721230200047 T(ph)ISPSTSNNIPLMR ddPTM_A459_Selumetinib_30min_R2 3 TISPSTSNNIPLMR 14 0 O94806;O94806-2;Q15139;F8WBA3 O94806;Q15139 PRKD3;PRKD1 Serine/threonine-protein kinase D3;Serine/threonine-protein kinase D1;Serine/threonine-protein kinase 1 T(0.978)IS(0.021)PS(0.001)TSNNIPLMR;T(0.623)IS(0.375)PS(0.002)TSNNIPLMR;T(0.954)IS(0.046)PSTSNNIPLMR 218.45 2.4465e-08 66127700.0 120935.0 106448.0 143378.0 119114.0 142953.0 80844.0 102652.0 110414.0 90788.0 108156.0 True False 114213.91684116241 114612.21931573299 134153.21557816278 102890.46771688889 124993.96612396519 91979.52717123639 107425.52140107914 110735.28645997829 108948.13682866722 105033.25525696423 1.087407188911147 1.0911993447726036 1.277245147262707 0.9795989609687618 1.1900418188331592 0.8757181422798728 1.0227762734598886 1.0542878652010168 1.0372727814835903 1.0 16.680486655645538 -5.7921919201332654 24.999916523779692 1.0259129737624255 1.1458757526063046 0.31174412536717633 0.08770594669354768 247.17606985267807 200937.89611028592 0.024380492506463767 0.036166517783461874 1.6136453093090724e-06 5.7921919201332654 0.11996277884387907 T(ph)ISQSSSLK ddPTM_A459_Selumetinib_30min_R1 1 TISQSSSLK 9 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 T(0.627)IS(0.367)QS(0.003)S(0.003)SLK 123.62 0.013025 72976000.0 5811.0 5914.1 5904.4 7137.1 6204.5 5129.9 5885.8 5153.6 3426.6 4627.5 True False 5946.384993762319 5221.674422609504 5102.614910547644 5890.739464959691 5643.304070493446 5078.29786357653 5441.829367315232 5016.90978674795 5814.689931037982 5221.484700667069 1.138830301083261 1.000036334865141 0.9772344846468212 1.1281732692249624 1.0807853309945517 0.9725773711311946 1.0421996193190057 0.9608205470959279 1.1136085355751648 1.0 12.350244372248806 -6.740103495391676 24.99917366535337 1.016914873810626 1.0600346234628077 0.1276912559241704 0.06093059524814085 583.2978997211966 683446.8169610965 0.020073280723382658 0.020054245312440266 1.8192672629220987e-07 6.740103495391676 0.043119749652181794 T(ph)ISQSSSLK ddPTM_A459_Selumetinib_30min_R2 2 TISQSSSLK 9 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 T(0.941)IS(0.058)QS(0.001)SSLK;T(0.98)IS(0.02)QSSSLK 123.62 0.013025 64670000.0 165200.0 184525.0 247550.0 240380.0 236370.0 178257.0 171490.0 186507.0 144248.0 205749.0 True False 156018.84534799724 198677.47415860894 231622.9025120604 207639.82932137128 206675.08742538898 202810.2836940662 179464.6248009885 187049.70449210404 173101.63062587165 199808.49176989813 0.7808419150056466 0.9943394917739948 1.1592245177387162 1.0391942178338036 1.034365885026541 1.015023345091984 0.8981831713522073 0.9361449197440154 0.8663377071341771 1.0 17.608258372752253 -7.253300617470627 23.272028295027134 0.9198451918871426 1.0134587486742104 0.14037624132593518 0.09319250956479727 429.238335331802 1227370.1392438845 0.03751178216678555 0.028492952102821878 5.580837569332735e-08 7.253300617470627 0.09361355678706773 T(ph)ITPETLCHVGVPSR ddPTM_A459_Selumetinib_30min_R1 1 TITPETLCHVGVPSR 15 0 Q9Y2G1-2;Q9Y2G1 Q9Y2G1-2 MYRF Myelin regulatory factor;Myelin regulatory factor, N-terminal;Myelin regulatory factor, C-terminal 1 T(0.999)IT(0.001)PETLCHVGVPSR 144.3 0.00050687 6089000.0 1729.2 1876.5 1946.4 2065.6 1804.6 1643.0 2053.2 1933.4 1284.9 1437.9 True False 1769.4869955625181 1656.7985076388184 1682.0895708098947 1704.8817361142112 1641.3742486280062 1626.4729117246407 1898.3254709591972 1882.1199514317145 2180.3814546170265 1622.4684713320742 1.0906141024174967 1.0211591392457438 1.0367471544324498 1.0507949869216715 1.0116524774625728 1.002468115999369 1.170023026333843 1.1600348386964106 1.3438667642193973 1.0 10.663974727943625 -7.305252111364673 6.893833740332426 1.1827212399383045 1.0346101997889536 0.3896607857748803 0.08071914430340381 0.2227249284828177 28.654071162479312 0.03210798932470648 0.02173338214102574 4.9516266153437646e-08 7.305252111364673 -0.14811104014935084 T(ph)KFASDDEHDEHDENGATGPVK ddPTM_A459_Selumetinib_30min_R1 3 TKFASDDEHDEHDENGATGPVK 22 1 P05455 P05455 SSB Lupus La protein 1 T(0.557)KFAS(0.443)DDEHDEHDENGATGPVK;T(0.5)KFAS(0.5)DDEHDEHDENGATGPVK;T(0.546)KFAS(0.453)DDEHDEHDENGAT(0.001)GPVK 80.98100000000002 0.0033283 190924000.0 12660.640000000001 15468.289999999999 12985.84 14382.22 12380.300000000001 11934.58 12710.849999999999 11241.36 6482.94 11397.079999999998 True False 12955.60827868301 13657.255415787076 11222.43425411321 11870.635264705912 11260.5040509195 11814.52896093163 11752.060350935957 10943.202615716578 11001.0756847964 12860.006234960252 1.0074340588936 1.06199446300885 0.8726616495414083 0.9230660582757176 0.875621974451889 0.9187032062872205 0.9138456184405015 0.8509484689025426 0.8554487053738511 1.0 13.650603721682188 -5.262207484102666 24.999999999989917 0.8968954398465951 1.034714268663222 0.6057899680313967 0.04293664479171851 38.39640613693834 1249765.6312561876 0.010581533738454725 0.024325900068670393 5.4675468854295485e-06 5.262207484102666 0.13781882881662688 T(ph)KFASDDEHDEHDENGATGPVK ddPTM_A459_Selumetinib_30min_R2 5 TKFASDDEHDEHDENGATGPVK 22 1 P05455 P05455 SSB Lupus La protein 1 T(0.837)KFAS(0.162)DDEHDEHDENGAT(0.001)GPVK;T(0.809)KFAS(0.189)DDEHDEHDENGAT(0.001)GPVK;T(0.946)KFAS(0.054)DDEHDEHDENGATGPVK;T(0.85)KFAS(0.149)DDEHDEHDENGATGPVK;T(0.827)KFAS(0.173)DDEHDEHDENGATGPVK 62.684 0.005935 475649000.0 749145.0 650114.0 713669.0 692733.0 690334.0 500298.0 564852.0 564427.0 440978.0 626983.0 True False 707510.5199650436 699975.6533540165 667752.3135240565 598381.5703689198 603608.0712557368 569209.5082469346 591118.7372330044 566069.3891240798 529185.9219547969 608880.3716925282 1.1619860860325475 1.1496111319999809 1.0966888482016255 0.982757201887746 0.991340991298281 0.9348462107009313 0.9708290244105733 0.929689008615198 0.8691131239520801 1.0 19.21579928036948 -5.676377247708426 1.0922753787466384 0.9384799716709687 1.180999604603942 0.8622871115842636 0.034165203536292287 0.20239241537206304 0.4481826244664884 0.012369978486377303 0.04005666977795838 2.106797296035988e-06 5.676377247708426 0.24251963293297318 T(ph)KFASDDEHDEHDENGATGPVKR ddPTM_A459_Selumetinib_30min_R1 2 TKFASDDEHDEHDENGATGPVKR 23 2 P05455 P05455 SSB Lupus La protein 1 T(0.741)KFAS(0.259)DDEHDEHDENGATGPVKR;T(0.885)KFAS(0.115)DDEHDEHDENGATGPVKR 66.01899999999999 0.0023841 92308000.0 10378.6 9823.2 22974.0 24325.0 13235.1 14136.400000000001 9570.2 9171.0 6565.3 5839.6 True False 10620.401186759858 8673.095177318213 19854.256987148845 20077.09538680197 12037.98754184669 13994.200650824238 8848.312108987771 8927.755288393639 11140.834589459999 6589.1695425208845 1.6117966184091699 1.316265292818685 3.013165294810885 3.0469841847658508 1.8269354679924046 2.123818572358412 1.3428569491023574 1.3549135791364169 1.6907797739254617 1.0 12.6858809331452 -7.225628650605911 4.149728067766072 1.3708736053002453 2.1919829225841454 0.35118703339320245 0.5373300206748964 0.28685756221486464 11.219848687176961 0.24216262499903302 0.1770950768394262 5.948005335112174e-08 7.225628650605911 0.8211093172839001 T(ph)KSNSLSEQLAINTSPDAVK ddPTM_A459_Selumetinib_30min_R2 1 TKSNSLSEQLAINTSPDAVK 20 1 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 T(0.25)KS(0.25)NS(0.25)LS(0.25)EQLAINTSPDAVK 78.794 0.006574299999999999 7342700.0 77529.0 53974.0 78513.0 81542.0 95775.0 54498.0 78142.0 76729.0 55079.0 59363.0 True False 73220.2485531771 58113.63224623625 73461.559058491 70435.83893220422 83742.88826063646 62004.604816412306 81775.75783543545 76952.2686868303 66096.33903584364 57649.035946403 1.2701036079987675 1.008059047167158 1.274289462997943 1.2218042813012393 1.4526329345471316 1.0755531952704072 1.418510413798825 1.3348405124827023 1.1465298239730186 1.0 15.815008861720116 -5.331432054077997 24.999764392910922 1.259850935944361 1.1390768972568126 0.058139849667158905 0.1477432767452486 318.92173842797666 113910.20069423293 0.036207845631233346 0.07537266128003503 4.661953591513245e-06 5.331432054077997 -0.12077403868754844 T(ph)KSPTDDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R1 1 TKSPTDDEVTPSAVVR 16 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 T(0.512)KS(0.09)PT(0.396)DDEVT(0.001)PSAVVR 143.99 0.0040455 31385000.0 1130.1 1461.5 1260.5 1309.0 1076.9 1037.5 1239.0 968.76 627.98 953.45 True False 1156.42913120819 1290.3869005670838 1089.3310234308833 1080.407722973229 979.4945851421371 1027.0636919746287 1145.5412324753777 943.0653378240349 1065.6361941554983 1075.8345948894678 1.0749135012961752 1.1994287102281362 1.012545077659268 1.0042507724751417 0.9104509092708357 0.9546669133466099 1.0647930805692967 0.876589526218876 0.9905204751897597 1.0 10.07124057122216 -5.442786395744293 3.9591231315097777 0.9688630451147241 1.1363529786292845 0.567188408226099 0.056736310208571755 0.1504860005074254 4.368412729679482 0.01482892773963111 0.03232832030413108 3.607560343542412e-06 5.442786395744293 0.16748993351456043 T(ph)KSPTDDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R2 1 TKSPTDDEVTPSAVVR 16 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 T(0.987)KS(0.009)PT(0.004)DDEVTPSAVVR 186.98 8.704400000000001e-06 7310500.0 17123.0 12693.0 16614.0 15460.0 16585.0 10549.0 14266.0 14369.0 9658.5 14310.0 True False 16171.372208799972 13666.512285572258 15545.073327955475 13354.321330012453 14501.444028218804 12002.028995712375 14929.397267542712 14410.81141108399 11590.469881038069 13896.833118154856 1.163673195994104 0.983426379907973 1.1186054546231368 0.960961480681979 1.0435071001373746 0.8636520920750567 1.0743021190949549 1.0369852820825538 0.8340367753208644 1.0 13.762468531183163 -1.5228787453202235 0.443057013425399 0.9690548113931153 4.513175349834911 0.28814607039287676 0.08307245962139827 118.64885442750993 1.4512459376458275 0.05118071096096816 378.69972171484557 0.02999999999724478 1.5228787453202235 3.5441205384417955 T(ph)KSSDDLLAGMAGGVTVTNGVK ddPTM_A459_Selumetinib_30min_R1 2 TKSSDDLLAGMAGGVTVTNGVK 22 1 F8WAN1;Q69YQ0-2;Q69YQ0;C9J8U1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 T(0.627)KS(0.186)S(0.186)DDLLAGMAGGVTVTNGVK;T(0.696)KS(0.152)S(0.152)DDLLAGMAGGVTVTNGVK 133.75 2.7375e-05 48299000.0 10289.6 8724.8 10093.5 9659.3 7378.200000000001 7891.4 8179.299999999999 9424.3 4854.9 9192.8 True False 10529.327659923722 7703.296359950522 8722.858139626836 7972.484582517421 6710.843112727014 7812.019680817915 7562.328815807787 9174.336949559276 8238.410712133391 10372.78542545482 1.0150916294946917 0.7426449159014347 0.8409369115282129 0.7685963080806569 0.6469663487165754 0.7531265094568731 0.7290547818766046 0.8844622320100682 0.7942332145342877 1.0 13.340515735599476 -10.053783999145022 9.981468261541051 0.9999999980619382 0.7909154871285452 0.28860376531485055 0.09503861764327977 0.0 0.0 0.09200130921216863 0.02231359503393426 8.835192185864684e-11 10.053783999145022 -0.20908451093339298 T(ph)KSTGGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R2 2 TKSTGGAPTFNVTVTK 16 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 T(0.709)KS(0.145)T(0.145)GGAPT(0.001)FNVTVTK;T(0.476)KS(0.476)T(0.047)GGAPT(0.001)FNVTVTK 93.851 0.0134 25503100.0 219823.0 207837.0 203556.0 196649.0 209689.0 149468.0 147864.0 158998.0 131177.0 205646.0 True False 207606.11768119092 223777.42959871492 190459.42857501563 169865.0669615537 183345.99317655538 170055.86026458774 154739.96898695765 159460.65785646415 157416.06539161652 199708.46564752408 1.0395459051175417 1.1205204990842572 0.9536873059310738 0.8505651796522109 0.9180682079854958 0.8515205387673862 0.7748292917139843 0.7984671923618131 0.7882293065605359 1.0 17.607535964398643 -5.5328473716041655 2.5652191146184093 0.8440096302368466 1.0810964053377472 0.6437867455112598 0.06637067580410493 0.16355549037336262 2.1439438933303148 0.018872994243559718 0.04255317920856159 2.9319234590070222e-06 5.5328473716041655 0.2370867751009006 T(ph)LDRSGDLGDMEPLK ddPTM_A459_Selumetinib_30min_R1 1 TLDRSGDLGDMEPLK 15 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14;O60716-27;O60716-29;O60716-25;O60716-26;O60716-31;O60716-32;O60716-30;O60716-28;H0YC95 O60716-5 CTNND1 Catenin delta-1 1 T(0.67)LDRS(0.33)GDLGDMEPLK 100.45 0.010495 5042800.0 1942.2 2376.9 2258.8 2614.1 2456.6 2390.7 2387.5 2161.9 1250.9 1937.6 True False 1987.4494811366662 2098.611443009168 1952.0673667002607 2157.5965077343903 2234.4009637479576 2366.6517285819223 2207.408952812722 2104.5593891591125 2122.6859378787753 2186.309833822259 0.9090429226410554 0.9598874828002898 0.8928594367100845 0.9868667625952768 1.0219964842959255 1.0824868881664302 1.0096505621774459 0.9626080240785339 0.9708989572478609 1.0 11.094282152297835 -5.915310336783084 5.419055263673835 1.009464666166314 0.9250876627779587 0.5627117485352322 0.034367624054739386 0.1690907289809461 8.227192117354058 0.010769465007640557 0.016179329766300245 1.2153172527149063e-06 5.915310336783084 -0.0843770033883553 T(ph)LLAKAVAT(ph)ECKT(ph)TFFNIS(ph)AS(ph)TIVSK ddPTM_A459_Selumetinib_30min_R1 1 TLLAKAVATECKTTFFNISASTIVSK 26 2 K7EM02;K7EIJ8;Q8IYT4-2;Q8IYT4 K7EM02 KATNAL2 Katanin p60 ATPase-containing subunit A-like 2 5 T(1)LLAKAVAT(0.662)ECKT(0.662)T(0.662)FFNIS(0.503)AS(0.503)T(0.503)IVS(0.503)K 41.76 0.032471 6889400.0 3520.6 3332.1 1112.1 1749.6 6963.5 1946.5 5699.1 4188.8 180.61 1103.9 True False 3602.6231301049074 2941.9761829487347 961.0829283280328 1444.0652040595576 6333.652654505781 1926.9199772805923 5269.212298628266 4077.6994168600254 306.48197876751595 1245.5963178965699 2.8922878771740694 2.3619017981016754 0.7715845932741734 1.1593364425628208 5.0848357236647725 1.5469859292251034 4.230272860413034 3.2736925746103753 0.24605241229764552 1.0 10.282620869451621 -8.265953872848986 24.922104432425343 0.6230259724312395 2.637253701504655 0.29136895554021924 1.2732693149471008 521.3003243315138 2877762.518137644 1.1256628162619482 0.32939550826997127 5.420584602895853e-09 8.265953872848986 2.014227729073416 T(ph)LPSPIDAK ddPTM_A459_Selumetinib_30min_R2 1 TLPSPIDAK 9 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 T(0.647)LPS(0.353)PIDAK 105.98 0.031421 8366700.0 138890.0 133420.0 142470.0 141930.0 160130.0 126500.0 126610.0 133230.0 111920.0 141100.0 True False 131171.0498207223 143652.88498708332 133303.63530960758 122598.88915709389 140013.0378196368 143924.22674733304 132497.6158729555 133617.67724258627 134307.12730608066 137026.07637817282 0.9572707129021819 1.0483616606712247 0.9728340680332127 0.8947121044226508 1.0217984891665466 1.0503418805492342 0.9669518340967496 0.9751259086906945 0.9801574332130167 1.0 17.064090941941124 T(ph)LSDESICSNR ddPTM_A459_Selumetinib_30min_R1 1 TLSDESICSNR 11 0 Q9P2F8;Q9P2F8-2 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 T(0.556)LS(0.282)DES(0.162)ICSNR 198.97 2.7644e-19 0.0 885.53 1021.9 996.64 1086.5 1219.7 985.12 1124.5 926.24 391.07 907.95 True False 906.1611260585682 902.2554729315788 861.3017621516511 896.7631711309494 1109.3783503555246 975.210587217394 1039.6780596598558 901.6731063484596 663.6172273772906 1024.4942266819376 0.8844960786098146 0.8806838041964791 0.840709239466558 0.8753228156641987 1.0828546627817552 0.951894663551048 1.0148208087292931 0.8801153611853307 0.6477510659348166 1.0 10.000696139034861 -12.10105626087242 2.278040633330173 3.0136352200351295 0.9030102117342621 0.07300877588379562 0.10881451406113385 3907324.2037986326 1111147.4599007433 40667747.462759376 0.028197993038712676 7.923986721916375e-13 12.10105626087242 -2.1106250083008673 T(ph)LSDESICSNR ddPTM_A459_Selumetinib_30min_R2 1 TLSDESICSNR 11 0 Q9P2F8;Q9P2F8-2 Q9P2F8 SIPA1L2 Signal-induced proliferation-associated 1-like protein 2 1 T(0.92)LS(0.077)DES(0.004)ICSNR 179.6 0.00012278 24869000.0 41090.0 30014.0 36130.0 33336.0 39915.0 32451.0 36383.0 33688.0 28118.0 26509.0 True False 38806.38229630268 32315.97728977909 33805.43513536967 28795.579292192422 34900.520855372546 36920.83068915181 38074.881591546786 33786.026502651366 33742.385682562344 25743.616291346396 1.5074176781195763 1.2553006121615464 1.3131579787697978 1.1185522253869178 1.3556961252217004 1.4341742151262014 1.479002839408599 1.312404058555223 1.3107088491644703 1.0 14.651927107511156 -8.951224853280538 2.137563361287773 1.0000425852642727 1.3421415116774151 0.48411103802022415 0.1067242325288474 3.3710935114136964 15.77120050636867 0.1085724873798338 0.02973321223692705 1.1188584514418223e-09 8.951224853280538 0.34209892641314243 T(ph)LSDESIYNSQR ddPTM_A459_Selumetinib_30min_R1 2 TLSDESIYNSQR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 T(0.999)LS(0.001)DESIYNSQR;T(0.654)LS(0.346)DESIYNSQR 225.79 5.4452e-09 37215100.0 1781.58 1968.1 2114.1000000000004 2119.3 1901.29 1564.3600000000001 1978.1799999999998 1717.75 916.92 1620.81 True False 1823.0873476487816 1737.6739370551336 1827.0168319200568 1749.2040391880546 1729.3186552000138 1548.6239587252344 1828.9642899581456 1672.1896899616363 1555.9462708128588 1828.8567515263514 0.9968453494934719 0.950142177950724 0.9989939509451689 0.956446718819383 0.9455735960494097 0.8467716005820376 1.00005880090483 0.914336067363416 0.8507753652735659 1.0 10.83672636250651 -6.251867415869869 2.8396474028002117 0.9204776471910453 0.9777613855716926 0.1983668263414975 0.05007106415837336 0.4322513561662926 7.002394670605562 0.015738480304979513 0.019873535277375096 5.599285138767536e-07 6.251867415869869 0.057283738380647264 T(ph)LSDESIYNSQR ddPTM_A459_Selumetinib_30min_R2 3 TLSDESIYNSQR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 T(0.998)LS(0.002)DESIYNSQR;T(0.955)LS(0.044)DESIYNSQR;T(0.962)LS(0.038)DESIYNSQR 234.04 4.8162e-10 66422000.0 48101.0 39747.2 44307.0 51093.0 50530.0 35054.1 38606.9 48509.0 38329.1 48034.0 True False 45427.73898355936 42795.68243260836 41456.33585781411 44134.04525965886 44181.96965606851 39882.484085562726 40402.19734812107 48650.153158902714 45995.99100453448 46647.13361267996 0.973859173443636 0.9174343441538996 0.8887220424310306 0.9461255567407904 0.9471529381187669 0.8549825251153607 0.8661239012795131 1.042939820544049 0.9860411013985975 1.0 15.509500812184392 -7.7667293962839645 24.999997650185342 1.0108678563241942 0.9129853391468764 0.5827498403388878 0.03728706223403267 97.72625502566764 461831.3749685403 0.020620872382893472 0.010363337218255171 1.7110811372703393e-08 7.7667293962839645 -0.09788251717731777 T(ph)LSDESLCSGR ddPTM_A459_Selumetinib_30min_R1 1 TLSDESLCSGR 11 0 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.693)LS(0.277)DES(0.03)LCSGR 128.36 0.0065263000000000005 200640000.0 3405.6 4204.3 4227.0 4487.7 3746.5 3451.8 3840.9 3634.3 2314.6 2862.0 True False 3484.9438538559516 3712.0586014739574 3652.9966172489817 3704.00743956223 3407.6297364983 3417.078025983639 3551.1778206736676 3537.906558129865 3927.7071483045893 3229.3655782407645 1.0791419458166196 1.1494699226639264 1.1311808863829518 1.1469768131919063 1.0552009841990844 1.058126725883148 1.0996518463568359 1.0955422891629327 1.2162472947532483 1.0 11.657035054217536 -6.243214289432202 24.856125962397467 1.0913814107370925 1.1286399640687503 0.10784262174002235 0.054469533138832314 1979.2122890286046 2699333.8408730086 0.015982921335789785 0.020580207273620265 5.711967274372333e-07 6.243214289432202 0.03725855333165784 T(ph)LSDESLCSGR ddPTM_A459_Selumetinib_30min_R2 3 TLSDESLCSGR 11 0 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(1)LSDESLCSGR;T(0.797)LS(0.189)DES(0.014)LCSGR;T(0.997)LS(0.003)DES(0.001)LCSGR 193.62 4.757e-05 56037000.0 77497.0 62021.0 81276.0 78473.0 91988.0 57520.0 59155.0 70711.0 59396.0 71933.0 True False 73190.02698507105 66777.81127105313 76046.79064661797 67784.84202652435 80431.64505684609 65442.85788542766 61905.82471340879 70916.7573031638 71276.85966290174 69856.10738562085 1.0477255278632438 0.9559337582671925 1.0886205013804047 0.9703495451347915 1.1513903088365054 0.9368237128382906 0.8861905856230324 1.0151833527122822 1.0203382686275093 1.0 16.0920986327614 T(ph)LSDPPSPLPHGPPNK ddPTM_A459_Selumetinib_30min_R2 1 TLSDPPSPLPHGPPNK 16 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 T(0.493)LS(0.493)DPPS(0.014)PLPHGPPNK 99.371 0.008928100000000001 23065000.0 142220.0 123030.0 170350.0 245300.0 255220.0 167800.0 136960.0 161540.0 141050.0 191250.0 True False 134315.98175176833 132466.00539619927 159389.8664630561 211889.71683389766 223156.98190425106 190912.92686326065 143328.9113810913 162010.05465561323 169263.94126628578 185728.11557282458 0.7231860471825151 0.7132253777929434 0.8581892190714595 1.1408596710324939 1.2015250422155417 1.027916135768917 0.7717135929529829 0.8722968741482147 0.9113533551139534 1.0 17.502832701811236 -5.4951876721810216 4.724629919313483 0.9868823911036115 0.7278921149542493 0.4613974984507473 0.11735247875319185 0.2037252141693452 11.375155167380397 0.037056667841516164 0.07530808224257649 3.19751306605006e-06 5.4951876721810216 -0.2589902761493622 T(ph)LSMIEEEIR ddPTM_A459_Selumetinib_30min_R1 4 TLSMIEEEIR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 T(0.962)LS(0.038)MIEEEIR;T(0.998)LS(0.002)MIEEEIR;T(0.983)LS(0.017)MIEEEIR;T(0.96)LS(0.04)MIEEEIR 220.29 0.0003259 164399000.0 7620.799999999999 8666.1 9556.2 9031.1 8613.5 7367.099999999999 7069.7 7046.5 4908.1 5051.9 True False 7798.349812504532 7651.468983239412 8258.520528449199 7453.987919742951 7834.41044583694 7292.993662791607 6536.426837151875 6859.603929742205 8328.687226559132 5700.360574673143 1.3680450052848958 1.342278068730441 1.4487716031757762 1.3076344596272071 1.3743710320089995 1.279391639748997 1.1466690135696673 1.2033631627128312 1.4610807715504377 1.0 12.476837464086824 -6.920254836485683 3.8265291303182196 1.2185873911707317 1.3677067446820743 0.3265600425674684 0.11098079753923404 0.2984541011963139 8.562692151563189 0.039938579962844736 0.03452822456795079 1.201559173592385e-07 6.920254836485683 0.14911935351134264 T(ph)LSMIEEEIR ddPTM_A459_Selumetinib_30min_R2 1 TLSMIEEEIR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 T(0.509)LS(0.491)MIEEEIR 118.77 0.013119 14297000.0 2972.1 2446.7 1160.6 4135.2 3030.1 2693.1 2568.8 2403.2 2436.8 4053.5 True False 2806.9225802589726 2634.354022619527 1085.9282595657357 3571.9786263821156 2649.431748562304 3064.050079472273 2688.254289980633 2410.1929141288215 2924.2280898807853 3936.464922742186 0.7130566727630431 0.6692182133771958 0.27586382220555034 0.9074077113568778 0.6730484839978403 0.7783760657361125 0.6829107696221931 0.612273438588106 0.7428563818736469 1.0 11.9426849073015 -14.52287874495007 0.19673985424046836 2.4718282870621247 0.6147975743984618 0.30798354443636844 0.15121347872216828 177.682689910959 1.747197999132363 102.63961862158193 0.3791793267865533 3.0000000022814073e-15 14.52287874495007 -1.8570307126636627 T(ph)LSPEFNER ddPTM_A459_Selumetinib_30min_R1 1 TLSPEFNER 9 0 Q9BSJ8;Q9BSJ8-2 Q9BSJ8 ESYT1 Extended synaptotagmin-1 1 T(0.5)LS(0.5)PEFNER 107.11 0.029879000000000006 3895700.0 2100.2 2035.2 1947.2 1660.7 2313.8 2188.8 1998.0 2470.1 994.59 1697.5 True False 2149.130573722184 1796.9178378611891 1682.780935203979 1370.6899201998783 2104.517198534568 2166.782659271391 1847.2892514009704 2404.584923984422 1687.7465880205057 1915.3906600502098 1.1220325015398411 0.9381469145380947 0.8785575550211082 0.7156189850920267 1.0987404514541177 1.1312484207344893 0.9644451598988928 1.2554018217471044 0.8811500563421685 1.0 10.903422956622963 T(ph)LSPEFNER ddPTM_A459_Selumetinib_30min_R2 2 TLSPEFNER 9 0 Q9BSJ8;Q9BSJ8-2 Q9BSJ8 ESYT1 Extended synaptotagmin-1 1 T(0.989)LS(0.011)PEFNER;T(1)LSPEFNER 141.89 0.0050695 11955200.0 55617.0 19395.8 39372.0 51259.0 42520.0 33609.0 52945.0 46054.0 48652.0 35414.0 True False 52526.029792491274 20883.395492673317 36838.84838499239 44277.435773292906 37178.25746637706 38238.33467787441 55407.04740852722 46188.00951534986 58383.759450459576 34391.50580337777 1.5272965973863355 0.6072253890849482 1.0711612511416773 1.2874526642257167 1.0810302310963538 1.1118540402531263 1.6110677946263525 1.3430063161355819 1.6976214936400198 1.0 15.069764663995318 -7.21570953502491 11.498261541385741 1.4414495902467153 1.0955625908205187 0.2149816332973008 0.27599331641675773 1.5037547046469506 376.30826031155607 0.1007460420574045 0.07794911062333405 6.085418703718896e-08 7.21570953502491 -0.3458869994261966 T(ph)LSPTPSAEGYQDVR ddPTM_A459_Selumetinib_30min_R1 1 TLSPTPSAEGYQDVR 15 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 T(0.628)LS(0.372)PTPSAEGYQDVR 212.35 1.808e-06 269270000.0 4176.5 4459.4 5243.0 5753.7 5207.1 4532.9 4751.6 3967.6 2431.8 3770.8 True False 4273.804323945672 3937.2913748811816 4531.029397737504 4748.92430532549 4736.118724388174 4487.303141543897 4393.182986464892 3862.3663594188843 4126.586988355266 4254.8189107024045 1.0044620966583353 0.9253722561440801 1.0649170958463898 1.1161284193271381 1.1131187540026972 1.05464021753234 1.0325193806520065 0.9077628074143507 0.9698619553408985 1.0 12.054882015353304 -7.637808768801879 6.620700947446553 0.9547041256747242 1.0475607846231485 0.3331942513090633 0.0553713873319021 0.26554496243309095 14.319073049551958 0.029795423746286777 0.017000227376431018 2.3024554254650724e-08 7.637808768801879 0.09285665894842432 T(ph)LSPTPSAEGYQDVR ddPTM_A459_Selumetinib_30min_R2 4 TLSPTPSAEGYQDVR 15 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 T(0.646)LS(0.354)PTPSAEGYQDVR;T(0.861)LS(0.139)PTPSAEGYQDVR;T(0.646)LS(0.354)PTPSAEGYQDVR;T(0.98)LS(0.02)PTPSAEGYQDVR 244.0 3.7488e-20 532618500.0 133640.0 114670.0 122033.0 132884.0 116276.0 88604.0 108523.0 107210.0 84591.0 100484.0 True False 126212.823803307 123464.82027783591 114181.52963948438 114784.9699623139 101668.36935937096 100808.3967329699 113569.53453424484 107521.96335042905 101511.56367002024 97582.76583121413 1.293392565052044 1.2652318186122042 1.1700993373868969 1.1762832195272461 1.041868084936469 1.0330553338417876 1.1638277883072359 1.1018540254987899 1.040261185521239 1.0 16.574338754332423 -5.546166284073898 1.0899073687548064 1.0719362543113635 1.3070820979665072 0.7586761927563893 0.047315542762958455 0.34983695653579694 0.7172400339836416 0.01749239676883264 0.07080216961400215 2.8433722194639457e-06 5.546166284073898 0.23514584365514368 T(ph)LSSPSLQTDGIAATPVPPPPPPK ddPTM_A459_Selumetinib_30min_R2 1 TLSSPSLQTDGIAATPVPPPPPPK 24 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 T(0.36)LS(0.36)S(0.093)PS(0.163)LQT(0.024)DGIAATPVPPPPPPK 164.99 6.9903e-14 5957100.0 32092.0 27754.0 35284.0 37563.0 42268.0 28144.0 29421.0 28576.0 24810.0 28094.0 True False 30308.455114454726 29882.642556824427 33013.86585431451 32446.854600210703 36957.91595928565 32020.58053420506 30789.134796605525 28659.15142898853 29772.693249319706 27282.85322302184 1.1108975614353933 1.0952902290882403 1.2100591380397383 1.1892764416894408 1.3546206350624572 1.1736521936490654 1.1285159416766943 1.0504455378884399 1.0912602507496132 1.0 14.735706907909154 -7.541871104058975 2.4501475300529805 1.0510585260838778 1.192833933860848 0.4592119075831014 0.06878983302967921 0.3060897519958715 3.6788340155892043 0.04199099131536079 0.02228944723969539 2.8716327385614643e-08 7.541871104058975 0.14177540777697017 T(ph)LSSSAQEDIIR ddPTM_A459_Selumetinib_30min_R1 1 TLSSSAQEDIIR 12 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 1 T(0.483)LS(0.172)S(0.172)S(0.172)AQEDIIR 203.85 9.6829e-05 10162000.0 1512.9 1935.8 2410.5 2682.6 2316.0 1714.6 1871.9 2408.2 988.14 1337.8 True False 1548.1476264090536 1709.1556360709953 2083.1673399287147 2214.134268638643 2106.5182089230093 1697.3526807322405 1730.701075924663 2344.3267130639583 1676.8014091098662 1509.5196612755055 1.0255895740376832 1.1322513246543622 1.3800200112454921 1.4667806756274748 1.39548908368842 1.1244323106716085 1.146524368196877 1.5530282733005691 1.110817866189972 1.0 10.55987383253048 -8.515374954193806 24.71594580880807 0.9999999521276154 1.280677840819301 0.2462048552915217 0.16166934959242804 573.8203440439748 1890044.6297933117 0.16357566323002698 0.04223505470898709 3.0522847427326922e-09 8.515374954193806 0.28067788869168553 T(ph)LSSSAQEDIIR ddPTM_A459_Selumetinib_30min_R2 1 TLSSSAQEDIIR 12 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 1 T(0.98)LS(0.007)S(0.007)S(0.007)AQEDIIR 215.09 2.2248e-06 100690000.0 153190.0 97256.0 146230.0 155330.0 143330.0 67575.0 112610.0 145890.0 85834.0 130940.0 True False 144676.3130681577 104715.22247267107 136821.72100318607 134173.78604080435 125323.60401354227 76882.84286522561 117846.58813248189 146314.51574661018 103003.19840234226 127159.42197702297 1.1377553532313158 0.8234955840833608 1.0759857105036938 1.055161968769006 0.9855628632551316 0.6046177441662005 0.9267625339927712 1.1506384149264883 0.8100319803353179 1.0 16.956278838045016 -4.736902872483375 24.154685910357934 0.940484378246793 1.137756700253357 0.1385776060205739 0.14998312249945084 3285.8374102311664 3234447.3432742553 0.038420596882533097 2.3756322067478655 1.8327242550059992e-05 4.736902872483375 0.19727232200656408 T(ph)LT(ph)DIS(ph)NQWDNT(ph)LHLASTY(ph)LSHQEK ddPTM_A459_Selumetinib_30min_R2 1 TLTDISNQWDNTLHLASTYLSHQEK 25 0 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2 G3V5X4 SYNE2 Nesprin-2 5 T(0.995)LT(0.994)DIS(0.977)NQWDNT(0.913)LHLAS(0.204)T(0.203)Y(0.534)LS(0.18)HQEK 50.539 0.032429 0.0 5866.4 6295.5 14870.0 12363.0 12988.0 14454.0 5869.7 10295.0 8771.7 13218.0 True False 5540.36897305987 6778.344606776978 13913.280389231852 10679.138072635447 11356.331325806805 16444.907299651783 6142.652680589901 10324.956745570997 10526.285101775806 12836.361995511585 0.4316152017991654 0.5280580751109327 1.0838959195835103 0.831944290474946 0.8847001455535226 1.2811190043878458 0.47853532665546256 0.8043522572190831 0.8200364796081997 1.0 13.647948759991172 -5.129444772924872 5.753695708240556 0.8861211665048229 0.45601729179565137 0.4196089320673283 0.1974319936379919 0.21262167232901802 8.867219622997643 0.0508202464827045 0.14106144549541993 7.422585810797211e-06 5.129444772924872 -0.4301038747091715 T(ph)LTEPSVDFNHSDDFTPISTVQK ddPTM_A459_Selumetinib_30min_R1 1 TLTEPSVDFNHSDDFTPISTVQK 23 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 T(0.395)LT(0.256)EPS(0.34)VDFNHS(0.009)DDFTPISTVQK 77.065 0.0010834000000000002 70917000.0 911.13 1299.7 1300.6 1146.9 1039.3 1202.9 1130.4 1050.4 559.74 884.41 True False 932.3575562496397 1147.530519785862 1123.985663684417 946.6154449793712 945.2954985033176 1190.7999181458138 1045.1330179097386 1022.539979819941 949.8378982079028 997.93263838292 0.9342890696114118 1.1499077950244767 1.126314162352438 0.9485764956172746 0.9472538146814226 1.1932668321936255 1.047298161931354 1.024658319099469 0.9518056246231695 1.0 9.962798625025846 -8.03292174798875 3.6994382242148225 0.9767675996170035 1.053580694365958 0.10371245728803868 0.08480198929673509 0.5450637844737636 15.384630347331647 0.06264378293018223 0.023079887670411 9.269968363973458e-09 8.03292174798875 0.07681309474895448 T(ph)LY(ph)GIY(ph)YK ddPTM_A459_Selumetinib_30min_R1 1 TLYGIYYK 8 0 A0A087WZW1;P04118 A0A087WZW1 CLPS Colipase 3 T(1)LY(1)GIY(1)YK 78.939 0.013928 0.0 671.8 622.04 612.29 652.6 472.31 630.29 575.69 527.45 370.86 415.57 True False 687.4516329047536 549.2112676214493 529.1443810682237 538.6356608191969 429.58964389310324 623.9498548575311 532.2652398093221 513.4603126009404 629.3223334572888 468.9124574945898 1.4660553839363188 1.1712447789421037 1.1284502525171851 1.1486913009245687 0.9161403947090908 1.3306318586443828 1.1351057778529232 1.0950024986420084 1.3420891754929538 1.0 8.873174797105863 -4.760096384509576 4.19594421249399 1.1401852559121433 1.4990468600156404 0.39195753138865796 0.12213395141485586 0.23778520601541683 8.314929301249201 0.029398883758992796 0.26475432534796145 1.7374151952625043e-05 4.760096384509576 0.3588616041034971 T(ph)LYGFGG ddPTM_A459_Selumetinib_30min_R1 1 TLYGFGG 7 0 P62805 P62805 HIST1H4A Histone H4 1 T(0.998)LY(0.002)GFGG 60.118 0.040394 5907400.0 1920.5 1919.6 2316.9 2035.0 1959.4 2043.7 2439.9 3170.5 799.03 1451.9 True False 1965.2439133575174 1694.8523396021715 2002.277705820717 1679.6254516810698 1782.1726159601678 2023.142233531131 2255.856378625241 3086.4080407645893 1355.8955511577888 1638.265507703622 1.199588164504681 1.0345406966285142 1.2221936532298332 1.0252461788293539 1.0878411390460525 1.2349293957650342 1.376978498306605 1.8839486189823085 0.8276409072778228 1.0 10.677953472902407 -6.977891724592081 3.732929946945149 1.3432142874287214 1.1116090396616891 0.04981004398005762 0.26674348230766437 0.45914617594783497 13.924204615245392 0.09790843805349246 0.08164860653739328 1.0522241746479501e-07 6.977891724592081 -0.23160524776703229 T(ph)MSQGEITK ddPTM_A459_Selumetinib_30min_R2 2 TMSQGEITK 9 0 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 T(0.607)MS(0.393)QGEITK;T(0.893)MS(0.107)QGEITK 108.98 0.027346 29540000.0 73635.0 54885.0 69885.0 68647.0 73118.0 46731.0 55331.0 56243.0 44131.0 63046.0 True False 69542.66148426005 59094.50301690958 65388.675185034816 59297.160177319805 63932.263156786335 53167.771068218346 57904.001136296516 56406.65781847011 52958.433123165174 61225.69816681976 1.1358410531273864 0.9651911662305037 1.067993949319652 0.9685011678552798 1.044206355680781 0.868389788277363 0.945746685950845 0.9212905611101507 0.8649706693237041 1.0 15.901849699724014 -6.75052889463957 24.999875936852597 0.9167643963381081 1.0303826505195064 0.4995875272369663 0.057980822217675254 177.11868864256965 405842.4543582148 0.017988745305104418 0.01782412507928049 1.776115095217137e-07 6.75052889463957 0.11361825418139826 T(ph)MVIIEMT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 TMVIIEMTK 9 0 Q6ZTR5 Q6ZTR5 CXorf22 Uncharacterized protein CXorf22 2 T(1)MVIIEMT(1)K 54.776 0.041906 0.0 12410.0 10493.0 12898.0 13563.0 13758.0 9900.2 12368.0 12443.0 10522.0 13113.0 True False 11720.30188116612 11297.779359687203 12068.156722280593 11715.696002519975 12029.597041919456 11263.862684932388 12943.136506727073 12479.207069950458 12626.694009243934 12734.393618334349 0.9203659186639096 0.8871862845060184 0.9476820871082122 0.9200042305628355 0.9446540920959 0.884522893081869 1.0163920556132477 0.979960840222774 0.9915426197494513 1.0 13.636442643075958 -7.267469098194688 24.998911960073478 0.9953039510876885 0.9187624183964854 0.7753433451014655 0.020967972584216708 238.2457161235949 987750.3912384425 0.008427509620796114 0.005843824314803042 5.4017054871206186e-08 7.267469098194688 -0.07654153269120312 T(ph)NRTSQDYDQLPSCSDGSQAPARPPKPR ddPTM_A459_Selumetinib_30min_R2 1 TNRTSQDYDQLPSCSDGSQAPARPPKPR 28 3 Q13191 Q13191 CBLB E3 ubiquitin-protein ligase CBL-B 1 T(0.317)NRT(0.317)S(0.317)QDY(0.048)DQLPSCSDGSQAPARPPKPR 48.913 0.016905 4760000.0 7232.2 8668.3 10857.0 9588.9 10787.0 11448.0 11092.0 12110.0 9059.3 11310.0 True False 6830.263276790464 9333.130737022455 10158.472440207821 8282.875278224861 9431.840622996457 13024.858085402906 11607.799978381028 12145.238095081575 10871.413137991207 10983.450913090945 0.6218686031226868 0.8497448398388608 0.9248889552645199 0.7541232117086877 0.8587319866613911 1.1858620927489056 1.0568445263906934 1.1057761527941934 0.9897994013005328 1.0 13.423043788446316 -6.6290666358116495 5.923419271341272 1.0725319500543384 0.8025922693636076 0.6943054195074005 0.08882983797764424 0.1227501438498618 6.018740146671776 0.0294865750419819 0.02942668594275581 2.3492723334702092e-07 6.6290666358116495 -0.2699396806907308 T(ph)NSAEVTPPVLSVMGEATPVSIEPR ddPTM_A459_Selumetinib_30min_R1 1 TNSAEVTPPVLSVMGEATPVSIEPR 25 0 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 T(0.333)NS(0.333)AEVT(0.333)PPVLSVMGEATPVSIEPR 66.372 0.0027372 2039700.0 541.24 593.32 982.29 1033.0 849.87 841.46 694.47 628.33 485.27 605.23 True False 553.8498389302902 523.8538185730156 848.9004133327423 852.6059418115703 772.999408556735 832.9956763845506 642.0855687789951 611.6646472965189 823.467747281504 682.9171659394332 0.8110058826364459 0.7670825170317587 1.2430503371005173 1.2484763662935756 1.1319080074570729 1.2197609284556008 0.9402100295659294 0.8956644785097794 1.2058091205669532 1.0 9.41556678800355 -5.248958766955434 24.99972996092063 1.1103806287517166 0.7890441433283688 0.5305125463868143 0.12100221156928016 634.777318890636 1271507.4621412402 0.03335940258565496 0.08695081171803684 5.636911715873594e-06 5.248958766955434 -0.3213364854233478 T(ph)NSMGSATGPLPGTK ddPTM_A459_Selumetinib_30min_R1 1 TNSMGSATGPLPGTK 15 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.895)NS(0.064)MGS(0.041)AT(0.001)GPLPGTK 208.59 3.7038e-06 31256000.0 3877.0 4349.6 4271.6 4856.5 3827.9 3640.2 4106.3 4038.2 2489.0 3599.5 True False 3967.3265566712284 3840.346809925821 3691.5401822192484 4008.403442795636 3481.667120870636 3603.5828930371513 3796.558484998905 3931.093818077768 4223.65121063256 4061.530887099102 0.9768057087225163 0.9455416976205101 0.9089036338354392 0.986919354849124 0.8572302458488439 0.8872474427028094 0.934760461149798 0.9678847526592376 1.0399160631889839 1.0 11.9878079004805 -7.988273393093204 2.931220839679146 1.0189607477293239 0.926055046488583 0.48380145133845465 0.03765546732803575 0.23399610557722486 3.942781888384569 0.028862451098455734 0.01061333725769749 1.027369354352012e-08 7.988273393093204 -0.09290570124074093 T(ph)NSMGSATGPLPGTK ddPTM_A459_Selumetinib_30min_R2 1 TNSMGSATGPLPGTK 15 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.76)NS(0.229)MGS(0.01)ATGPLPGTK 172.56 8.9488e-05 85445000.0 16547.0 15421.0 17592.0 16227.0 16511.0 15078.0 15469.0 16384.0 11298.0 16886.0 True False 15627.38398288927 16603.741113669716 16460.149872721377 14016.854606863655 14436.740569787195 17154.85763554377 16188.339151241986 16431.674727482787 13557.91569249553 16398.45730490307 0.9529789109013778 1.0125184829859128 1.0037620958283595 0.8547666616586351 0.8803718728755461 1.0461263103337495 0.9871867121550355 1.0020256431420402 0.826779948894447 1.0 14.001272478340868 T(ph)NSPAYSDISDAGEDGEGKVDSVK ddPTM_A459_Selumetinib_30min_R2 1 TNSPAYSDISDAGEDGEGKVDSVK 24 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.525)NS(0.422)PAY(0.036)S(0.017)DISDAGEDGEGKVDSVK 126.93 1.886e-07 8467800.0 32449.0 31739.0 31559.0 33420.0 27252.0 17266.0 26885.0 24599.0 14531.0 27940.0 True False 30645.614483638976 34173.27924302985 29528.528298841167 28868.13834728434 23828.360124028877 19644.23477485733 28135.205771616864 24670.579017416327 17437.606030063063 27133.299603161882 1.1294466552850726 1.259459031626496 1.0882763515941927 1.063937625334749 0.8781961822753074 0.7239898966275432 1.036925334666567 0.9092362292178217 0.6426644118148842 1.0 14.727776879865958 -6.018170446115378 1.8778366778139624 0.8603053639324004 1.1806832802138298 0.5755652853920797 0.11601013196232446 0.24544938064578745 1.7357927243179068 0.03806950172056864 0.06064009868300676 9.590241726096654e-07 6.018170446115378 0.3203779162814294 T(ph)NSSSSSPVVLK ddPTM_A459_Selumetinib_30min_R1 2 TNSSSSSPVVLK 12 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 T(0.605)NS(0.381)S(0.014)S(0.001)SSPVVLK;T(0.725)NS(0.014)S(0.128)S(0.128)S(0.004)S(0.001)PVVLK 173.33 0.00044 46089000.0 4704.0 5773.3 6525.900000000001 5882.5 5354.2 4967.8 5235.4 5070.4 3401.1 4603.200000000001 True False 4813.594047609347 5097.359352065644 5639.7186242027765 4855.231803200931 4869.913555360786 4917.828442401503 4840.489562955278 4935.916521019638 5771.41829348429 5194.065558965025 0.9267488045662076 0.9813814042580836 1.085800431315032 0.9347652138931395 0.9375918536405939 0.9468167828404219 0.9319269285310676 0.9502992338054304 1.111156227807473 1.0 12.342648508342794 -8.244027477614303 24.831814626156493 1.0555781192522755 0.9634758154438463 0.3524589950092596 0.05074584511825235 750.9959451268063 1071030.65835895 0.03565349429781117 0.013401422504707319 5.701281993877866e-09 8.244027477614303 -0.09210230380842921 T(ph)NSSSSSPVVLK ddPTM_A459_Selumetinib_30min_R2 2 TNSSSSSPVVLK 12 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 T(0.6)NS(0.111)S(0.287)S(0.001)SSPVVLK;T(0.511)NS(0.046)S(0.431)S(0.001)S(0.003)S(0.008)PVVLK 164.7 0.0011751 64348000.0 317590.0 262200.0 294890.0 308030.0 302910.0 215364.0 270720.0 249240.0 174493.0 257700.0 True False 299939.6192135012 282309.89689411875 275917.0984519562 266075.7826186111 264855.73775024165 245028.436120258 283309.0164215034 249965.24713609685 209396.47574177958 250259.53141499014 1.1985142684381105 1.1280685107093142 1.1025238355234497 1.0631993958999062 1.058324277412026 0.9790973184311701 1.1320608442749351 0.998824083633381 0.8367172852831334 1.0 17.93306549120348 -4.073610658680696 0.2723735458331769 0.9499234816699454 1.4899885197879394 0.5534083581571341 0.06462686962219819 10.661942525341768 0.48601388336091467 0.08273704049457979 2.0559679113570697 8.440911392154937e-05 4.073610658680696 0.540065038117994 T(ph)NTPQGVLPSSQLK ddPTM_A459_Selumetinib_30min_R1 1 TNTPQGVLPSSQLK 14 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 T(0.525)NT(0.475)PQGVLPSSQLK 156.72 0.00074544 15118000.0 3759.3 3364.7 4563.3 4646.3 2635.5 3370.5 2784.8 3170.7 2175.7 3370.4 True False 3846.8843756755614 2970.7593597934074 3943.6289244126533 3834.9109268529496 2397.119490335316 3336.595830169146 2574.7402939446565 3086.602736114896 3692.0039931592046 3803.023670476127 1.0115331139114219 0.7811572099474936 1.0369719639212562 1.0083847115189875 0.6303193716475617 0.8773534217186229 0.6770245249676048 0.8116180711881982 0.970807523976567 1.0 11.89293120316576 -4.741931275169688 23.888910179591097 0.8569557123037682 1.0115340353239877 0.09214738058235994 0.13443093253922608 1908.319531607877 2336641.9875021065 0.03402845454993805 1.1678225915406464 1.811626750396028e-05 4.741931275169688 0.15457832302021945 T(ph)NTPQGVLPSSQLK ddPTM_A459_Selumetinib_30min_R2 1 TNTPQGVLPSSQLK 14 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 T(0.955)NT(0.044)PQGVLPSSQLK 150.59 0.00097752 17395000.0 88912.0 87512.0 70863.0 67709.0 66021.0 47857.0 84358.0 61071.0 50377.0 60491.0 True False 83970.6269829365 94223.88900456927 66303.75172980085 58486.91739546006 57726.85174477133 54448.86734740804 88280.81415220573 61248.70649915167 60453.807650986615 58744.467655506975 1.4294218729729984 1.6039619178630227 1.1286807826504361 0.9956157529325612 0.9826772468736424 0.9268765131503197 1.502793670204106 1.0426293563222022 1.0290978889366 1.0 15.842165369749866 -5.318242074446897 5.890938588516995 1.0790960599347057 1.5161034977812091 0.5587906541931967 0.1568114130257415 0.1458557457343452 11.072393903095755 0.04265984618507622 0.09196948571542075 4.80571404715712e-06 5.318242074446897 0.4370074378465034 T(ph)NTPVKEDWNVR ddPTM_A459_Selumetinib_30min_R1 1 TNTPVKEDWNVR 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 T(0.99)NT(0.01)PVKEDWNVR 143.58 0.0084365 12769000.0 1066.1 1569.4 1512.5 1811.7 1082.6 1182.8 1049.3 1254.2 792.99 1190.0 True False 1090.9380557305121 1385.6539184057335 1307.1108075678 1495.3206048209308 984.6790211485543 1170.902105896473 970.1504562037235 1220.9345417842444 1345.646112301935 1342.7480915815909 0.8124666589140501 1.0319537425472003 0.9734594416948197 1.1136270564790962 0.7333311641416853 0.8720191920118802 0.7225111413571301 0.9092804148737496 1.0021582758065444 1.0 10.390972955686175 -4.488172446753252 16.191984150920835 0.9189325284154446 0.42429335423052866 0.0734882956184647 0.11936274623497362 2251269.983955318 31885729.46301583 0.0312699979515935 31594581.2031031 3.2495823951628944e-05 4.488172446753252 -0.49463917418491593 T(ph)PAPEPEPCEASELPAKR ddPTM_A459_Selumetinib_30min_R2 2 TPAPEPEPCEASELPAKR 18 1 H0Y5D5;A0A494C0L7;Q9BTG3;Q5SYW2;F5H2X7;Q9ULV3-5;Q9ULV3-3;Q9ULV3-4;Q9ULV3-2;Q9ULV3 H0Y5D5 CIZ1 Cip1-interacting zinc finger protein 1 T(1)PAPEPEPCEASELPAKR;T(1)PAPEPEPCEASELPAKR 102.24 0.00293 16088100.0 47180.0 42163.0 48298.0 45870.0 45270.0 44189.0 50101.0 45298.0 40098.0 43567.0 True False 44557.92447650423 45396.76652458705 45190.55926288634 39622.42686983642 39582.777881065136 50275.633642196844 52430.79577324808 45429.80968051244 48118.72043172999 42309.107509339774 1.0531520776387928 1.072978590119531 1.0681047633280962 0.936498763560298 0.9355616369909765 1.188293410138667 1.2392319020597145 1.0737595840442573 1.1373135304522257 1.0 15.368680632593511 -6.7702591485382255 24.99960241836633 1.1392991756609085 1.015359418819348 0.36321707250353563 0.0749717781154165 210.7099533211513 597252.9666800473 0.027457981125303003 0.02456918316922088 1.6972305931231128e-07 6.7702591485382255 -0.12393975684156056 T(ph)PAQSGAWDPNNPNTPSR ddPTM_A459_Selumetinib_30min_R2 2 TPAQSGAWDPNNPNTPSR 18 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 T(0.988)PAQS(0.012)GAWDPNNPNTPSR;T(1)PAQSGAWDPNNPNTPSR 192.22 8.5454e-21 0.0 15133.5 16731.2 17133.9 15362.5 19341.7 17310.300000000003 16661.8 21747.0 19357.7 14119.900000000001 True False 14292.440654200454 18014.429240712714 16031.523527979793 13270.10099820934 16911.822729008105 19694.636697741968 17436.606714730355 21810.280169590347 23229.780899329133 13712.221799093977 1.0423139928457703 1.3137498433625834 1.1691412057701007 0.9677571725893575 1.2333393506022152 1.43628341098182 1.2716106091488735 1.5905723003278318 1.6940931411176576 1.0 13.74317473030452 -6.64667664124444 3.865353585911657 1.4281605936648427 1.1359735757639582 0.3034300933275219 0.19390236049732593 0.2722610492941572 7.613602709283923 0.06615277288180937 0.06561980875547942 2.2559182558654326e-07 6.64667664124444 -0.2921870179008845 T(ph)PASGLQTPTSTPAPGSATR ddPTM_A459_Selumetinib_30min_R2 1 TPASGLQTPTSTPAPGSATR 20 0 Q96DF8 Q96DF8 DGCR14 Protein DGCR14 1 T(0.986)PAS(0.013)GLQT(0.001)PTSTPAPGSATR 200.9 7.7132e-24 0.0 9103.7 6797.9 9212.7 9894.6 11861.0 7073.3 7200.9 6815.2 6262.4 7936.1 True False 8597.75279899855 7319.277071306364 8619.96491202934 8546.938410862955 10370.915141314628 8047.582869975578 7535.756118312653 6835.0311036829 7515.0549860757665 7706.964172535898 1.1155822975844387 0.9496965221907903 1.118464380922771 1.108988989636197 1.3456550347375216 1.0441962217306642 0.9777852796003188 0.8868642633684259 0.9750992502152782 1.0 12.911946968962452 -7.148613277060507 3.829086480390168 0.9501346252185802 1.1216154179622362 0.40256887525730145 0.09462177323619193 0.258709553665125 6.734577818740893 0.04058567135944765 0.030732007322972137 7.102099017432126e-08 7.148613277060507 0.17148079274365602 T(ph)PASINATPANINLADLTR ddPTM_A459_Selumetinib_30min_R2 2 TPASINATPANINLADLTR 19 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 T(0.608)PAS(0.388)INAT(0.004)PANINLADLTR;T(0.99)PAS(0.01)INATPANINLADLTR 172.99 4.1259e-09 4951300.0 9797.3 8583.2 10992.099999999999 9131.4 9935.4 6833.9 7245.7 7783.0 5942.0 10425.8 True False 9252.80528769935 9241.503840662084 10284.880253293577 7887.687567456389 8687.22622839705 7775.207693032399 7582.639407082175 7805.64724145499 7130.566033351783 10124.780064518432 0.9138771636260173 0.9127609470795591 1.0158127078074717 0.779047793353875 0.8580162900368388 0.7679384286361003 0.7489189255236262 0.7709448690949171 0.7042687335343057 1.0 13.305602948951668 -5.775457881859764 24.995807115431305 0.793050959864109 0.9440113404167616 0.39300206524468706 0.08076746842319234 205.51325985581647 366441.6589000496 0.021742266374794185 0.032428454761474816 1.6770349677228877e-06 5.775457881859764 0.1509603805526526 T(ph)PASTPVSGTPQAS(ph)PMIER ddPTM_A459_Selumetinib_30min_R1 2 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2 T(0.981)PAS(0.013)T(0.006)PVSGTPQAS(1)PMIER;T(0.972)PAS(0.027)T(0.002)PVSGTPQAS(1)PMIER 219.21 6.009600000000001e-17 51153000.0 5148.3 6616.6 5003.8 6130.3 6173.4 5008.6 5714.6 5929.8 3017.0 5544.6 True False 5268.245373152045 5841.925396026115 4324.311443905952 5059.7581849830285 5615.017060002293 4958.218031444942 5283.543121149143 5772.522441295019 5119.628647038345 6256.303418977548 0.8420699925089346 0.9337663161133649 0.6911927306448739 0.8087456515671889 0.8974975610949414 0.7925155957757642 0.8445151661158754 0.9226730314557551 0.818315274081613 1.0 12.611094767006719 -10.02616762479135 0.3901689015655337 1.0444395568182152 0.8255040026745525 0.34937894919770995 0.0665706246923217 9.788773064190808 1.4417085349372767 0.6401122103110719 0.047349219189158236 9.415261252186702e-11 10.02616762479135 -0.21893555414366273 T(ph)PCEEILVK ddPTM_A459_Selumetinib_30min_R2 4 TPCEEILVK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 T(1)PCEEILVK;T(1)PCEEILVK;T(1)PCEEILVK;T(1)PCEEILVK 114.89 0.019503 30210200.0 85432.0 63146.0 82370.0 85729.0 88491.0 67389.0 84879.0 76266.0 83007.0 68381.0 True False 80684.03145139277 67989.09515360802 77070.40387767521 74052.56230922617 77373.96946042273 76671.22305356544 88826.0416845477 76487.9214334841 99610.71940936227 66406.66285482497 1.214999037487854 1.023829420584535 1.1605823958683603 1.1151375347849701 1.1651537079882173 1.154571239653773 1.3376073704943567 1.1518109500653313 1.5000109194935212 1.0 16.019040379937444 -7.103221922768748 6.312486487655213 1.2597105524004102 1.1327024796192458 0.14488136573043175 0.12795047593827788 0.40249526853990686 20.93452056546089 0.04548288949585168 0.03522089824271871 7.884571161821001e-08 7.103221922768748 -0.12700807278116444 T(ph)PDTIRR ddPTM_A459_Selumetinib_30min_R2 1 TPDTIRR 7 1 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 T(1)PDTIRR 95.358 0.030059 0.0 26095.0 19887.0 16319.0 24078.0 18812.0 8050.1 10487.0 17058.0 9378.4 21772.0 True False 24644.74436656165 21412.26895321637 15269.053306783757 20798.534863133224 16448.6683785862 9158.92820346803 10974.666279596273 17107.635955896076 11254.342054390161 21143.385789550484 1.1656006569554065 1.0127171289566488 0.7221668969560235 0.98368989102078 0.7779581067245855 0.4331817190790024 0.5190590754400456 0.8091247128617894 0.532286652970798 1.0 14.367918800294227 -4.885306655883814 0.69755054715314 0.6568505038023081 1.4270762946381483 0.42944289925692336 0.17621575690958002 2.5499446555512457 1.0340094490218064 0.07892328118935399 1.522264108770983 1.3022469355285942e-05 4.885306655883814 0.7702257908358402 T(ph)PDTSTYCYETAEK ddPTM_A459_Selumetinib_30min_R1 5 TPDTSTYCYETAEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(1)PDTSTYCYETAEK;T(1)PDTSTYCYETAEK;T(1)PDTSTYCYETAEK;T(0.992)PDT(0.007)S(0.001)TYCYETAEK;T(1)PDTSTYCYETAEK 146.84 0.0011459 476230000.0 14551.27 16513.64 14628.44 13957.25 14391.1 12057.81 15667.490000000002 14699.88 8119.35 14240.06 True False 14890.286279157428 14580.215351817038 12641.978196269158 11519.878297531015 13089.427545955059 11936.519379015517 14485.678615331432 14309.991430460352 13777.943936138814 16067.910410930543 0.9267095657334503 0.9074120392094377 0.786784209829125 0.716949373186346 0.8146315987081116 0.7428793834259521 0.901528465423683 0.8905944248186541 0.8574819988270579 1.0 13.971894702103063 -8.68662181387881 0.7785326545142345 0.9969864978964041 0.8203912161681453 0.3650289207544448 0.06679386362960918 1.0285442312529032 1.320145859695195 0.0721159011311044 0.026145151275651722 2.0576816570050725e-09 8.68662181387881 -0.1765952817282589 T(ph)PDTSTYCYETAEK ddPTM_A459_Selumetinib_30min_R2 6 TPDTSTYCYETAEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(1)PDTSTYCYETAEK;T(0.996)PDT(0.003)STYCYETAEK;T(1)PDTSTYCYETAEK;T(1)PDTSTYCYETAEK;T(0.999)PDT(0.001)STYCYETAEK;T(0.995)PDT(0.005)STYCYETAEK 254.45 1.3437000000000004e-27 716456700.0 280300.0 234637.0 269822.0 296605.0 323878.0 266010.0 307568.0 325464.0 274667.0 267849.0 True False 264722.048129804 252632.90342313217 252461.94627998114 256206.88732783616 283189.5501339434 302650.4629016448 321870.52143442974 326411.0463565339 329608.0748371983 260115.50341472114 1.0177096122861171 0.9712335485837654 0.9705763130829715 0.9849735366190258 1.08870692602445 1.1635233537737544 1.2374138304292 1.2548696331879647 1.2671604364607214 1.0 17.988792863848325 -6.592904084321904 1.9152067085292634 1.209898950716609 0.9822474289898094 0.6205383960058692 0.07239415837995025 0.19477242001328102 1.4559537101214992 0.026502586290747147 0.027371721807290375 2.553265139242216e-07 6.592904084321904 -0.22765152172679948 T(ph)PDYFL ddPTM_A459_Selumetinib_30min_R1 1 TPDYFL 6 0 P67775;P62714;H0YBN9;P67775-2 P67775 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 T(1)PDYFL 79.116 0.026547 2059000.0 1118.8 1951.1 986.98 1248.2 1041.4 1029.6 1205.2 1179.7 490.86 1112.6 True False 1144.8658631941632 1722.6643049582176 852.9535370930686 1030.2253016158772 947.2055538741034 1019.243158802003 1114.2907936879133 1148.4105237943497 832.9535690040573 1255.4130476417458 0.9119435753394136 1.3721892632820638 0.6794206406372111 0.8206265687226394 0.7544971399280894 0.8118787364179617 0.8875889857772895 0.9147670768211331 0.6634896543163499 1.0 10.29394639285712 -5.271877150651687 24.998250093687716 0.8137916031569279 1.14206643264783 0.45817263942901854 0.14157726697824974 496.6831654854564 1189547.479144438 0.03434882388148641 0.0727407693524827 5.347155935825138e-06 5.271877150651687 0.32827482949090214 T(ph)PEAPAHSEKPR ddPTM_A459_Selumetinib_30min_R2 1 TPEAPAHSEKPR 12 1 B8ZZZ7;Q9NUQ6-2;Q9NUQ6;Q9NUQ6-4;Q9NUQ6-3 B8ZZZ7 SPATS2L SPATS2-like protein 1 T(1)PEAPAHSEKPR 104.81 0.0054429 1963000.0 14409.0 12097.0 14087.0 13358.0 18232.0 15882.0 17437.0 14559.0 18250.0 15101.0 True False 13608.205463797152 13024.801002014312 13180.657756765917 11538.617356164708 15941.53316385198 18069.60133755845 18247.855050760005 14601.364279627798 21900.509947605187 14664.994892890041 0.9279379613282206 0.8881558498413841 0.8987836581624882 0.786813595261388 1.0870466222651627 1.2321587201042292 1.244313767855932 0.9956610545228971 1.4933868103986252 1.0 13.84008894822335 -6.454874066496965 4.262323090794327 1.1939767967563792 0.8795221380112227 0.5512506062722582 0.13519261482189912 0.16519569813396204 5.815452265206908 0.04107724899126073 0.04576525655708619 3.5085359713555277e-07 6.454874066496965 -0.31445465874515655 T(ph)PEDGDYSYEIIEK ddPTM_A459_Selumetinib_30min_R2 2 TPEDGDYSYEIIEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(1)PEDGDYSYEIIEK;T(1)PEDGDYSYEIIEK 238.88 4.4495e-19 19008400.0 42886.0 27562.1 40009.0 41342.0 46468.0 42887.0 48702.0 54282.0 45652.0 34666.2 True False 40502.56780626033 29676.024443880196 37434.86449850553 35711.14828107211 40630.27441080925 48794.29496057603 50966.73950118222 54439.95163313112 54783.67562345602 33665.2967323955 1.2030955238034617 0.8815019418891235 1.1119719156517234 1.060770340595511 1.2068889436436032 1.4493944713584588 1.513925152845537 1.6170940676944796 1.6273041066273652 1.0 15.038974560625656 -6.630987259769818 2.2230869368361064 1.4931911493710173 1.0531067119524093 0.4804576841361857 0.1824593575813412 0.22697663017656775 2.2883511192799193 0.06479129565525518 0.06498918248061607 2.3389058505415758e-07 6.630987259769818 -0.4400844374186079 T(ph)PEEGGYSYDISEK ddPTM_A459_Selumetinib_30min_R1 6 TPEEGGYSYDISEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK 193.45 0.00016514 479542800.0 18861.6 22303.96 14878.52 14063.41 18809.52 14139.29 21153.17 19954.4 10708.95 20316.949999999997 True False 19301.03858171525 19692.60199437031 12858.098705860273 11607.499446401025 17108.202237090467 13997.061580048152 19557.56935638513 19425.144490973937 18172.30599923807 22924.828436351756 0.8419272857505757 0.8590076060566663 0.5608809130920809 0.5063287377974479 0.7462739485527446 0.6105634168172487 0.853117370569841 0.847340888282139 0.792691035821335 1.0 14.484623316643468 -7.28167506577005 21.23061653757472 0.8605659826739108 0.6839744414123715 0.3767614706534226 0.11655272428361824 150.3410789686772 157729.83848666734 0.05227729374246706 0.035341764928769184 5.2278718618361174e-08 7.28167506577005 -0.1765915412615393 T(ph)PEEGGYSYDISEK ddPTM_A459_Selumetinib_30min_R2 6 TPEEGGYSYDISEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(1)PEEGGYSYDISEK;T(0.999)PEEGGY(0.001)SYDISEK;T(1)PEEGGYSYDISEK 189.33 0.00017378 577909100.0 566972.0 470937.0 579437.0 703317.0 714970.0 547187.0 700048.0 725182.0 664113.0 512914.0 True False 535461.966008745 507056.353598878 542156.6542633056 607524.0113105023 625149.0766871024 622557.0423809718 732601.6191187955 727292.1595596578 796954.1568676122 498104.8401093842 1.0749985201732977 1.0179711433591532 1.0884388397917346 1.2196709656085445 1.2550552139782847 1.249851421327803 1.4707779570218904 1.4601186356670293 1.5999727219928246 1.0 18.92608990425454 -6.295845370699612 0.9546694960225838 1.4096528387547873 1.0389199822817325 0.4077576290726309 0.15178061829575654 0.49426667574483935 0.9602538237399236 0.07090021494350242 0.10812182670336831 5.060047914836521e-07 6.295845370699612 -0.37073285647305476 T(ph)PEGISEEQR ddPTM_A459_Selumetinib_30min_R1 2 TPEGISEEQR 10 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 T(1)PEGISEEQR;T(1)PEGISEEQR 126.71 0.007976 21676000.0 957.55 952.3199999999999 819.54 895.97 829.74 1006.66 902.68 866.22 786.27 1025.54 True False 979.8590519320431 840.8219316784426 708.250969410985 739.5056589398963 754.6901635024948 996.5339143741493 834.5901208481631 843.2450317208959 1334.242763111316 1157.1780486055336 0.8467660211087048 0.7266141391911829 0.6120501250991309 0.6390595291978131 0.6521815414766466 0.8611759578182719 0.7212287874401804 0.7287081125822037 1.153014235552736 1.0 10.17639514571739 -8.252740098814028 24.51946509092589 1.0765071198269769 0.7191887403798918 0.7381636969468724 0.08407275073382893 217.13972352767868 612027.4006933284 0.06139985270798671 0.022367548915696898 5.588045082312353e-09 8.252740098814028 -0.3573183794470851 T(ph)PEGISEEQR ddPTM_A459_Selumetinib_30min_R2 2 TPEGISEEQR 10 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 T(1)PEGISEEQR;T(1)PEGISEEQR 145.14 0.0021342 50353000.0 7808.8 10359.5 28437.0 21400.2 18630.0 12313.5 13865.9 14865.9 15647.8 17117.1 True False 7374.818157103145 11154.04033895736 26607.394379864567 18485.455842595882 16289.532845686841 14009.57285417617 14510.691824759606 14909.157307817764 18777.797236062273 16622.884847433146 0.44365452957113766 0.6710050897500943 1.6006484207807767 1.1120486012059663 0.9799462003854414 0.8427882995495504 0.8729346294545439 0.8969055278103542 1.129635283430474 1.0 14.020883158403661 -5.0137278037418165 24.652313861150894 1.0426999364039298 0.5004918476203338 0.4964782091932384 0.20559820800307013 419.1136095308411 752652.7727148144 0.05540331503014678 0.16238288380435587 9.688849195141448e-06 5.0137278037418165 -0.5422080887835959 T(ph)PELPEPSVK ddPTM_A459_Selumetinib_30min_R1 2 TPELPEPSVK 10 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.999)PELPEPS(0.001)VK;T(1)PELPEPSVK 111.63 0.02042 82913000.0 9040.5 10144.9 10792.6 10839.4 10256.0 8303.2 9947.7 9551.7 5059.3 8583.3 True False 9251.126060249226 8957.130391763947 9327.024199508256 8946.502270737974 9328.34661084387 8219.677346702396 9197.336980060785 9298.357887705763 8585.262583348063 9685.050163422075 0.9551965043184115 0.9248408878244853 0.963033132728007 0.9237435139496329 0.9631696742340704 0.848697446890465 0.949642678650932 0.9600732810680993 0.8864448235665703 1.0 13.241543805904952 -10.607039159622941 4.340270471892417 1.0000066633704168 0.9311096013222853 0.2548273786747599 0.035622703878615054 48854116.49653176 0.9083143466795132 3562.8279533972623 0.00832286107896462 2.4715012837413072e-11 10.607039159622941 -0.06889706204813151 T(ph)PELPEPSVK ddPTM_A459_Selumetinib_30min_R2 3 TPELPEPSVK 10 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(1)PELPEPSVK;T(1)PELPEPSVK;T(1)PELPEPSVK 139.86 0.0034647 46278000.0 299326.0 265465.0 303490.0 340300.0 340419.0 256031.0 257769.0 265162.0 221513.0 254873.0 True False 282690.6592169166 285825.3118954893 283963.78381492716 293950.5529497569 297652.5218355273 291296.9462319877 269755.7692595838 265933.57752006757 265821.7895903483 247514.15425041813 1.142119165156548 1.1547837042333768 1.147262808767016 1.1876110836568867 1.2025676783493464 1.1768900534765905 1.0898599721560291 1.0744176563373984 1.0739660137634301 1.0 17.917151503398763 -7.457677927902316 2.376334021822785 1.053923464019368 1.1696253987702487 0.8116579229184617 0.026157417093027227 0.14051431228797734 1.5614607945103285 0.014762476813782479 0.008348700407751925 3.485957372462397e-08 7.457677927902316 0.11570193475088075 T(ph)PENLITEIR ddPTM_A459_Selumetinib_30min_R1 4 TPENLITEIR 10 0 Q7Z4H7;Q5VY60;Q7Z4H7-3;Q5SYF9 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 T(1)PENLITEIR;T(1)PENLITEIR;T(1)PENLITEIR;T(1)PENLITEIR 140.01 0.0034268 24730000.0 2404.6099999999997 2258.64 1463.96 1636.6299999999999 2344.8 1843.82 2695.83 2574.34 1082.13 1869.68 True False 2460.6327344434353 1994.1973787867516 1265.1622729566654 1350.8232938500196 2132.713254008063 1825.2728448546131 2492.4813726748157 2506.060140565183 1836.295574351873 2109.6716402254356 1.1663581609223779 0.9452643438737487 0.5996962981506793 0.6403002572029044 1.010921895779082 0.8651928622691102 1.1814546515914077 1.1878910882536156 0.8704177177807869 1.0 11.042802752844414 -6.990369157360633 2.3232128965066274 1.071348072893179 0.8442125681121675 0.18632547985261194 0.17933452399203872 0.4797073115020492 5.206611706609942 0.08068274443507434 0.06419688039550189 1.0224235461975708e-07 6.990369157360633 -0.22713550478101152 T(ph)PENLITEIR ddPTM_A459_Selumetinib_30min_R2 3 TPENLITEIR 10 0 Q7Z4H7;Q5VY60;Q7Z4H7-3;Q5SYF9 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 T(1)PENLITEIR;T(1)PENLITEIR;T(1)PENLITEIR 150.14 0.0016871 24477800.0 3510.94 4810.700000000001 3884.73 2858.63 5013.0 5847.8099999999995 5979.32 6151.98 4651.700000000001 2697.4 True False 3315.8160102063966 5179.665221161466 3634.790701174219 2469.2796625881942 4383.222123211385 6653.292746366178 6257.370227797803 6169.881243284887 5582.169979357535 2619.519053313131 1.2658109915301434 1.9773344326739288 1.3875794095015217 0.9426461928059214 1.6732927052649407 2.53989095362799 2.3887477435537523 2.355348870427687 2.1309904092116776 1.0 11.355086240282496 -6.570113827827067 6.949452797128373 2.1822201890286532 1.4189350133368361 0.3189847758968364 0.46525975249791535 0.21591586399417945 24.780729308348725 0.14928118667154516 0.14984088924891978 2.690829449784154e-07 6.570113827827067 -0.7632851756918171 T(ph)PEPAPR ddPTM_A459_Selumetinib_30min_R2 1 TPEPAPR 7 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7ENL0;K7ER34;K7EJ51 Q9UHD8 SEPT9 Septin-9 1 T(1)PEPAPR 109.71 0.036774 18481000.0 12895.0 9434.7 7400.7 14206.0 11826.0 9437.4 15651.0 17050.0 14525.0 13481.0 True False 12178.34752277495 10158.311152658052 6924.547019272908 12271.118293283113 10340.312154218604 10737.31618581249 16378.802511868145 17099.612677220546 17430.405862409065 13091.76850215553 0.9302293667024293 0.7759311624694181 0.5289237292985128 0.9373155575782371 0.7898331041001905 0.8201578101571697 1.2510763927097712 1.3061346657943984 1.3314019308803993 1.0 13.676372376523451 -7.246726245037069 5.408712292897453 1.249804890523551 0.7878196528873257 0.7024978085654717 0.13506509961445498 0.09217111838194429 9.263320966120506 0.054026683767381276 0.039521624236789385 5.665963271480733e-08 7.246726245037069 -0.46198523763622534 T(ph)PESFLGPNAALVDLDSLVSRPGPTPPGAK ddPTM_A459_Selumetinib_30min_R1 2 TPESFLGPNAALVDLDSLVSRPGPTPPGAK 30 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 T(0.999)PES(0.001)FLGPNAALVDLDSLVSRPGPTPPGAK;T(0.785)PES(0.215)FLGPNAALVDLDSLVSRPGPTPPGAK 153.63 4.0768e-20 86621000.0 1452.5700000000002 2099.1 1825.8600000000001 1794.86 1551.38 1400.7 1645.49 1539.116 855.29 1385.07 True False 1486.4120547907985 1853.3363961548846 1577.9182407310693 1481.4213946949808 1411.0579529183856 1386.6102297338439 1521.3693645084008 1498.2936439266457 1451.3646620899647 1562.857226224297 0.9510862731727695 1.18586417559866 1.0096368460624892 0.9478929807772289 0.9028706712559772 0.8872277047876934 0.9734538376124564 0.9586887521046115 0.9286610688017313 1.0 10.609970272579686 -5.594750097755144 3.950855454626166 0.9386521077102419 1.074749389878251 0.40310156261538266 0.06128135265998627 0.17930807962849138 5.499405908311252 0.016118409359544943 0.03001184559056773 2.54243525582216e-06 5.594750097755144 0.1360972821680091 T(ph)PETLLPFAEAEAFLKK ddPTM_A459_Selumetinib_30min_R1 1 TPETLLPFAEAEAFLKK 17 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 1 T(1)PETLLPFAEAEAFLKK 178.23 1.0784e-07 8671200.0 621.64 587.98 679.49 675.33 640.31 551.01 559.09 742.65 404.79 483.77 True False 636.1230024991233 519.139028255514 587.2189901714008 557.3962930141407 582.3940735559124 545.4673396770511 516.9173911740585 722.9525095328249 686.8990653081372 545.8665918188451 1.1653451814655682 0.9510364547603581 1.0757555032169457 1.0211218297072886 1.0669164999003815 0.9992685902603716 0.9469665279416956 1.324412448697261 1.2583643615546563 1.0 9.092404593596276 -7.757294635085199 24.999599787406133 1.2185413064340163 1.030512716369164 0.35572020705687135 0.0982179817087283 92.20246324521848 556142.4715201043 0.04533818914638151 0.02496222154334411 1.7486599561116315e-08 7.757294635085199 -0.18802859006485217 T(ph)PGPPGLTTTPAPPDK ddPTM_A459_Selumetinib_30min_R2 1 TPGPPGLTTTPAPPDK 16 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 T(1)PGPPGLTTTPAPPDK 102.78 0.011128 3597700.0 33999.0 33882.0 37024.0 35561.0 29016.0 27719.0 29081.0 36726.0 27774.0 33340.0 True False 32109.471688780595 36480.64045219881 34641.91614868325 30717.530453853367 25370.75067366878 31537.040641970947 30433.32412290829 36832.86657968342 33329.57607039927 32377.387572276926 0.9917252161590167 1.1267320555360458 1.0699416705980727 0.948734062786313 0.7835947423810201 0.9740452521553801 0.9399561362068248 1.1376108247603487 1.029409058899417 1.0 14.982698963442912 -10.69471782350117 14.927098977826583 1.0000000323923932 0.999584170672686 0.0 0.0972441834982999 0.0 0.0 0.1037673554601725 0.025167280414900284 2.0196781938829185e-11 10.69471782350117 -0.0004158617197072001 T(ph)PHSPPLAK ddPTM_A459_Selumetinib_30min_R1 1 TPHSPPLAK 9 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 T(0.973)PHS(0.027)PPLAK 112.3 0.022863 19728000.0 4622.8 4903.6 5065.2 6317.7 6004.9 4527.0 5232.6 4977.3 2678.2 4147.2 True False 4730.502245597047 4329.484232378209 4377.37366115201 5214.4322929167065 5461.7578552512 4481.462490187126 4837.90076920957 4845.285835451056 4544.709792011298 4679.533517148884 1.0108918395949895 0.9251956880984258 0.9354294920872855 1.1143060037517847 1.167158614258394 0.9576729120037508 1.0338425297052205 1.0354206926170626 0.9711886399267142 1.0 12.192149005488131 -5.737786517592987 24.9982773714865 1.0430359731899708 0.9539746338009399 0.2664329439693309 0.06272246929947672 315.6418076573022 333593.60514296184 0.017916368576489906 0.03101009648597568 1.828999060559478e-06 5.737786517592987 -0.08906133938903082 T(ph)PISPLK ddPTM_A459_Selumetinib_30min_R1 1 TPISPLK 7 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 T(0.998)PIS(0.002)PLK 101.72 0.046166000000000006 16585000.0 4866.8 5351.6 5280.1 5444.9 4861.8 5212.0 4623.6 4389.7 2897.5 4488.4 True False 4980.186970855695 4725.03218410866 4563.091421513213 4494.050428431575 4422.051048420507 5159.572012117365 4274.838129518282 4273.270896244854 4916.845874973018 5064.529860718326 0.983346353524971 0.9329656086653 0.9009901307731669 0.8873578697380141 0.8731414701923205 1.018766233789282 0.8440740299854727 0.8437645771208379 0.9708395468470273 1.0 12.306212634815658 -4.827307629717232 2.8152226019167945 0.9102870255348787 0.9926543621186845 0.09267255572972355 0.05857468546748485 0.8138877073268284 9.622978575935537 0.014760635719197805 0.149315399581583 1.4883064718775916e-05 4.827307629717232 0.0823673365838058 T(ph)PKDSPGIPPSANAHQLFR ddPTM_A459_Selumetinib_30min_R1 2 TPKDSPGIPPSANAHQLFR 19 1 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 T(0.968)PKDS(0.032)PGIPPSANAHQLFR;T(0.905)PKDS(0.095)PGIPPSANAHQLFR 98.572 0.0019954 125486000.0 8153.200000000001 9670.7 9502.2 11441.9 10442.0 8866.099999999999 8305.8 6096.9 2463.75 5866.7 True False 8343.153696634472 8538.449948213543 8211.853431848423 9443.786956063701 9497.522943684835 8776.915083774707 7679.28681896206 5935.190406477721 4180.803804819593 6619.748091497241 1.260343079723965 1.2898451467029064 1.240508448107892 1.4266082070696628 1.434725734636936 1.3258684412852881 1.1600572578925998 0.8965885596313246 0.6315653929776635 1.0 12.692560602289362 -7.674282602485879 2.4207956989443384 0.8009668445196322 1.3311872871233354 0.8184851065405073 0.1027175007288739 0.11490237460692902 1.3496156675434263 0.06347624364683131 0.029915368053566024 2.1169831315827874e-08 7.674282602485879 0.5302204426037033 T(ph)PKDSPGIPPSANAHQLFR ddPTM_A459_Selumetinib_30min_R2 2 TPKDSPGIPPSANAHQLFR 19 1 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 T(0.63)PKDS(0.37)PGIPPSANAHQLFR;T(0.5)PKDS(0.5)PGIPPSANAHQLFR 82.774 0.0028017 102897000.0 364730.0 338060.0 429780.0 479290.0 495380.0 310720.0 289640.0 307950.0 232350.0 349590.0 True False 344459.7667298726 363988.11496577284 402128.42270908365 414009.8751786328 433145.93564660987 353518.85956467455 303108.8339107719 308846.08351613325 278826.49240142835 339496.42835609795 1.014619707187519 1.0721412202427814 1.1844849875336272 1.2194822702063235 1.2758482843073768 1.0413036192353353 0.8928189182386358 0.9097182112095284 0.8212943321717868 1.0 18.373036871233623 -7.070064945668913 3.8083782563091417 0.9002834572629973 1.155065197044602 0.6787386876583485 0.07982825690094057 0.14630992426021808 4.101841369230333 0.03407659139727696 0.026601087310692138 8.51010766043643e-08 7.070064945668913 0.2547817397816047 T(ph)PLSEAEFEEIMNR ddPTM_A459_Selumetinib_30min_R1 1 TPLSEAEFEEIMNR 14 0 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 T(1)PLSEAEFEEIMNR 142.1 0.0012835999999999998 3793800.0 184.02 335.23 594.5 697.57 532.37 444.09 464.98 301.28 167.0 272.94 True False 188.3073079594117 295.9811157558011 513.7701653547485 575.7524945106456 484.2172274975576 439.6228578014581 429.90618424245446 293.28907570463804 283.3868028025864 307.9745076607389 0.6114379705960885 0.9610571927006714 1.6682230268250375 1.869481012840478 1.5722639876121358 1.427465088395373 1.395914835639689 0.9523160794455166 0.920163181540863 1.0 8.266667127728955 -7.7623076252809495 24.99998673513773 0.9521795964749821 1.3852315568838378 0.22630313520605505 0.33666792492169445 37.060564757129974 1066983.833778264 0.19203102771632358 0.10069123410095553 1.7285915063892614e-08 7.7623076252809495 0.43305196040885574 T(ph)PLSEAEFEEIMNR ddPTM_A459_Selumetinib_30min_R2 1 TPLSEAEFEEIMNR 14 0 F8WJN3;Q16630-3;Q16630;Q16630-2 F8WJN3 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 T(1)PLSEAEFEEIMNR 152.88 0.00087502 2197000.0 3550.8 1837.1 3145.2 4632.2 4644.5 1667.5 3870.5 4609.8 1766.5 3369.8 True False 3353.460750978622 1977.9996627924686 2942.841256234837 4001.2863690092913 4061.016387643187 1897.1829889421163 4050.4859192502513 4623.213754806528 2119.8493601339483 3272.505118208121 1.0247381225838474 0.6044298148800249 0.8992625373940459 1.2226982768479882 1.240950354836059 0.579734154848604 1.2377324932857914 1.4127445451752252 0.6477757203003808 1.0 11.676179733213871 -5.532372343896868 22.171568075010992 1.0622320556111782 0.798899514208895 0.11506270411140118 0.2661994920167527 90.74851694173636 211934.2114950608 0.07137215097487719 0.12395984753493205 2.935132127090458e-06 5.532372343896868 -0.2633325414022831 T(ph)PNSSCSTPSR ddPTM_A459_Selumetinib_30min_R2 1 TPNSSCSTPSR 11 0 Q8N3J3-3;Q8N3J3-4;Q8N3J3 Q8N3J3-3 C17orf53 Uncharacterized protein C17orf53 1 T(1)PNSSCSTPSR 117.79 0.012853 973680.0 0.0 570.69 1200.8 0.0 811.76 1283.1 0.0 0.0 686.89 618.43 True False 0.0 614.4600879424275 1123.5418353321859 0.0 709.7794515735235 1459.8353781778903 0.0 0.0 824.287193310166 600.5743190258912 0.0 1.0231208169857455 1.870779018913976 0.0 1.1818345025554187 2.4307322706466836 0.0 0.0 1.3724982357672713 1.0 9.23019897534891 -12.68429800720102 1.2286200524754807 4.032146581272617 0.8865657875146996 0.00187711759582454 0.8269867205533874 6030818.043208863 86416.94647799821 51032010.07864128 0.24086169121537251 2.068721332090467e-13 12.68429800720102 -3.145580793757917 T(ph)PPAPSPFDLPELK ddPTM_A459_Selumetinib_30min_R2 3 TPPAPSPFDLPELK 14 0 O95239 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 T(1)PPAPSPFDLPELK;T(0.999)PPAPS(0.001)PFDLPELK;T(1)PPAPSPFDLPELK 140.31 0.0013179 6825400.0 37932.5 34152.1 36637.6 40847.9 42287.8 35298.6 36113.4 37531.4 35295.7 40939.0 True False 35824.3635058287 36771.45625369041 34280.37670400276 35284.345553442145 36975.22850627141 40160.6617412127 37792.74465734453 37640.61016034227 42355.826244256896 39756.984697703825 0.9010835147137742 0.9249055614575861 0.8622479034729873 0.8875005441617407 0.9300310068134247 1.0101536131720823 0.9505938376540728 0.9467672271060389 1.0653681753360729 1.0 15.27892072179596 -6.571321813003561 3.9226556775313957 0.9882705894317971 0.8948162808101595 0.6555113349558068 0.03443514376040724 0.14966055207202442 4.852321770702174 0.011787334902564455 0.012059612188576544 2.6833553375816175e-07 6.571321813003561 -0.09345430862163762 T(ph)PPGEVVWVER ddPTM_A459_Selumetinib_30min_R1 1 TPPGEVVWVER 11 0 A0A494C030 A0A494C030 1 T(1)PPGEVVWVER 110.98 0.019906 4914800.0 357.53 448.34 451.71 455.69 438.88 404.62 548.5 594.05 234.23 336.08 True False 365.85975336772356 395.84814437238845 390.37026306542185 376.11229586071096 399.18338149055745 400.5498901655657 507.1262034001167 578.2938642536518 397.47120251766364 379.2191416964209 0.9647713238605661 1.0438506416147098 1.0294054812716387 0.9918072547134315 1.0526456541851432 1.0562491344021365 1.337290626025651 1.524959583175782 1.0481306421917231 1.0 8.566887978202661 -7.173010616018394 5.324794388910656 1.2705849911874685 1.0214405634406316 0.3210145956297922 0.14071742825431868 0.22056127213456056 10.151710102375548 0.052976089957980914 0.04064301693401038 6.714124405278388e-08 7.173010616018394 -0.24914442774683687 T(ph)PPGPCCSPGVGWAQR ddPTM_A459_Selumetinib_30min_R1 1 TPPGPCCSPGVGWAQR 16 0 H3BSW6;Q2VPK5-3;Q2VPK5;Q2VPK5-5 H3BSW6 CTU2 Cytoplasmic tRNA 2-thiolation protein 2 1 T(0.954)PPGPCCS(0.046)PGVGWAQR 138.55 0.00094573 5778600.0 121.38 163.47 195.32 184.63 144.65 188.73 215.74 171.33 165.66 138.54 True False 124.20791783563413 144.33085640485876 168.79661681596204 152.3878364343371 131.56643304003174 186.83154755312944 199.46655810672948 166.7857718417274 281.11292067231426 156.32295849387688 0.7945596669378499 0.9232863668615391 1.0797941546287568 0.9748269729702311 0.8416321844701088 1.1951638412757366 1.275990168229464 1.066930753157799 1.7982830121739626 1.0 7.288385866211415 -6.899563060853384 4.596835629200886 1.2844750700837788 0.935378376083024 0.4037226421212108 0.21088394864841284 0.22457458209596548 8.194477098502098 0.07356741966341768 0.06453736933266971 1.2601926408808583e-07 6.899563060853384 -0.3490966940007548 T(ph)PPPPSSTFPK ddPTM_A459_Selumetinib_30min_R2 2 TPPPPSSTFPK 11 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PGF6 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 T(1)PPPPSSTFPK;T(1)PPPPSSTFPK 122.18 0.009885 42834000.0 130318.0 117234.0 131374.0 146765.0 151256.0 92916.0 132368.0 122250.0 97266.0 126895.0 True False 123075.44726428749 126225.47083327646 122921.53986919594 126775.35381625364 132253.86903420332 105714.33559253115 138523.37428221607 122605.72726042313 116721.91783911052 123231.21163719514 0.9987359990148743 1.0242978962577818 0.99748706708402 1.0287601016980406 1.0732173065340929 0.8578535761196976 1.1240932588575252 0.9949243023057056 0.9471782050050062 1.0 16.911008178288846 T(ph)PPRDLPTIPGVTSPSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R1 9 TPPRDLPTIPGVTSPSSDEPPMEASQSHLR 30 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 T(0.713)PPRDLPT(0.212)IPGVT(0.009)S(0.027)PS(0.027)S(0.012)DEPPMEASQSHLR;T(0.89)PPRDLPT(0.11)IPGVTSPSSDEPPMEASQSHLR;T(0.885)PPRDLPT(0.115)IPGVTSPSSDEPPMEASQSHLR;T(0.718)PPRDLPT(0.277)IPGVT(0.002)S(0.001)PS(0.001)S(0.001)DEPPMEASQSHLR;T(0.684)PPRDLPT(0.262)IPGVT(0.037)S(0.013)PS(0.001)S(0.002)DEPPMEASQSHLR;T(0.517)PPRDLPT(0.39)IPGVT(0.009)S(0.079)PS(0.003)S(0.001)DEPPMEASQSHLR;T(0.883)PPRDLPT(0.112)IPGVT(0.003)S(0.001)PS(0.001)SDEPPMEASQSHLR;T(0.893)PPRDLPT(0.103)IPGVT(0.001)S(0.001)PS(0.001)S(0.001)DEPPMEASQSHLR;T(0.956)PPRDLPT(0.042)IPGVT(0.001)S(0.001)PSSDEPPMEASQSHLR 126.79 1.1728e-17 335386000.0 10810.73 13061.15 10124.7 10741.279999999999 14651.35 10700.64 14680.340000000004 13251.04 4784.32 9224.43 True False 11062.598974981252 11531.944486036096 8749.82135099616 8865.517086797467 13326.137979405941 10593.001277003752 13572.990134590471 12899.579373755932 8118.6416070926325 10408.475444057118 1.06284527781613 1.107937905797764 0.8406438962194034 0.8517594276363858 1.2803160319713016 1.0177284208372699 1.3040324884793941 1.239334179447111 0.78000295535386 1.0 13.345471148439284 -6.251239526441042 24.861685877034116 1.1212668698510582 0.9670101047870381 0.13798028915338623 0.16517351844942826 1248.2186781137261 3042477.2343055913 0.04944554768206554 0.06311005648089887 5.607386265508279e-07 6.251239526441042 -0.15425676506402008 T(ph)PPRDLPTIPGVTSPSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R2 7 TPPRDLPTIPGVTSPSSDEPPMEASQSHLR 30 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 T(0.985)PPRDLPT(0.014)IPGVTSPSSDEPPMEASQSHLR;T(0.419)PPRDLPT(0.356)IPGVT(0.122)S(0.034)PS(0.034)S(0.034)DEPPMEASQSHLR;T(0.52)PPRDLPT(0.455)IPGVT(0.017)S(0.005)PS(0.002)S(0.001)DEPPMEASQSHLR;T(0.907)PPRDLPT(0.091)IPGVT(0.001)SPSSDEPPMEASQSHLR;T(0.724)PPRDLPT(0.273)IPGVT(0.002)S(0.001)PSSDEPPMEASQSHLR;T(0.951)PPRDLPT(0.049)IPGVTSPSSDEPPMEASQSHLR;T(0.4)PPRDLPT(0.315)IPGVT(0.085)S(0.03)PS(0.085)S(0.085)DEPPMEASQSHLR 90.287 1.5983000000000004e-06 722688500.0 47182.4 35997.9 55516.6 62324.5 71917.4 49237.630000000005 49143.600000000006 51657.299999999996 40979.2 49574.8 True False 44560.191094112226 38758.823178507984 51944.72239790374 53835.795584240695 62882.493262286596 56019.66659779671 51428.87477619599 51807.614190673594 49176.18505451521 48143.44671320076 0.9255712695346754 0.8050695541056982 1.0789572817116286 1.1182372526202846 1.3061485530292214 1.1635990030276815 1.0682424771655241 1.0761093716305967 1.0214512755488128 1.0 15.555051811308656 -5.3539278999377835 4.971485055514155 1.1180212329244963 0.866463336473706 0.5543841150783857 0.08533425664552322 0.1519309877142881 6.082992570162292 0.024028428686020963 0.052252225890966 4.426618554472791e-06 5.3539278999377835 -0.2515578964507903 T(ph)PPSPSGQPEEPGMVR ddPTM_A459_Selumetinib_30min_R2 1 TPPSPSGQPEEPGMVR 16 0 M0R0S1;M0R2P6;Q8TBC3;M0QXA4;Q8TBC3-2 M0R0S1 SHKBP1 SH3KBP1-binding protein 1 1 T(0.963)PPS(0.037)PSGQPEEPGMVR 106.6 0.0097591 0.0 4662.5 4717.8 5965.0 7463.2 7924.7 3800.3 4315.8 6189.8 4549.4 3840.5 True False 4403.376915466322 5079.640089882046 5581.218394200944 6446.699285261896 6929.128338283115 4323.75682931138 4516.493251595463 6207.811293223446 5459.40712085671 3729.6147861826494 1.180651935363353 1.36197446146474 1.4964597456225381 1.728516121596635 1.8578670279713378 1.1593038630503847 1.2109811630756115 1.6644644686153474 1.4637991947807953 1.0 11.864810913865618 -6.8015452987706615 24.999995170586615 1.3356934777616976 1.5257442335433415 0.17153985832758256 0.24125661797186393 363.73654046268695 226732.42884105258 0.09149564180774801 0.08069258266904614 1.5792638751755074e-07 6.8015452987706615 0.190050755781644 T(ph)PPTANHPVEPVTSVTQPSELLQQK ddPTM_A459_Selumetinib_30min_R2 1 TPPTANHPVEPVTSVTQPSELLQQK 25 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 1 T(0.83)PPT(0.17)ANHPVEPVTSVTQPSELLQQK 106.02 4.2011e-07 6522900.0 18627.0 11958.0 19255.0 19214.0 20511.0 18939.0 23165.0 24838.0 14659.0 22641.0 True False 17591.785909788985 12875.140148969747 18016.15426325887 16597.02005400125 17934.224809333475 21547.675338875426 24242.21840057668 24910.274467847736 17591.209606681885 21987.29550161734 0.8000886652246507 0.5855717974965442 0.8193892815027497 0.754845908755827 0.8156630636093589 0.980005719088572 1.102555718996612 1.132939449784326 0.8000624544927735 1.0 14.424382539160295 -6.677296293466936 2.390198016037997 1.023518799952119 0.7351442133683735 0.6051382419832986 0.10148738567467701 0.19155877396422744 2.2364457747678057 0.03768156420650628 0.03669314118442207 2.1023436455213284e-07 6.677296293466936 -0.2883745865837454 T(ph)PPTPPSSIVAK ddPTM_A459_Selumetinib_30min_R1 1 TPPTPPSSIVAK 12 0 Q96QT6;Q96QT6-4 Q96QT6 PHF12 PHD finger protein 12 1 T(0.991)PPT(0.007)PPS(0.002)SIVAK 92.247 0.043543 0.0 988.71 1349.0 1166.9 1506.2 1322.1 1108.0 1269.7 1361.6 654.54 858.66 True False 1011.7450193052381 1191.0584528669149 1008.4413893228855 1243.170444875689 1202.5162884357126 1096.854525983508 1173.9255067586655 1325.485944899877 1110.7065742898494 968.8773750566786 1.044244654021415 1.2293180577131744 1.0408349036573306 1.2831040097339095 1.2411439459667084 1.1320880786583987 1.2116347609933524 1.368063677637572 1.1463850874057968 1.0 9.920170273792392 -5.7635647654360085 24.99999613265678 1.2125078752653982 1.1172510988108943 0.12723965587530406 0.10475198431798483 104.5967215591521 1230350.4508821496 0.027871673658564654 0.04373338423900168 1.7235950357048595e-06 5.7635647654360085 -0.09525677645450381 T(ph)PPVALNSSR ddPTM_A459_Selumetinib_30min_R2 1 TPPVALNSSR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(1)PPVALNSSR 101.71 0.03757 278740000.0 17459.0 13179.0 17146.0 17042.0 21741.0 17774.0 13861.0 17130.0 16913.0 13409.0 True False 16488.69867391453 14189.786922835958 16042.845027153282 14720.850200910232 19009.70121299396 20222.20716369247 14505.563965050444 17179.845463975842 20296.072588703904 13021.84732923399 1.2662334503720891 1.0896907761297392 1.2319945566507424 1.1304732599545986 1.4598313689577105 1.552944574791144 1.1139405645223253 1.31930939056605 1.55861699769274 1.0 13.668646508826642 -6.247968751802712 24.759337389536825 1.350006163733791 1.1769186695206848 0.15817211143992482 0.17225388546192438 1195.915763741207 2198121.4552249657 0.049949485078658505 0.06408929143375078 5.649776244127136e-07 6.247968751802712 -0.1730874942131062 T(ph)PPVPDSGSANGSFFAPSR ddPTM_A459_Selumetinib_30min_R2 2 TPPVPDSGSANGSFFAPSR 19 0 Q9NPA3 Q9NPA3 MID1IP1 Mid1-interacting protein 1 1 T(1)PPVPDSGSANGSFFAPSR;T(0.998)PPVPDS(0.002)GS(0.001)ANGSFFAPSR 189.99 6.5453999999999994e-15 18082400.0 7863.8 5515.3 13771.4 14764.5 15261.4 11398.14 7173.5 10568.300000000001 15264.9 11731.0 True False 7426.761477285595 5938.305775515378 12885.36311716661 12753.549629816878 13344.12649335294 12968.130322986932 7507.081964020588 10599.052003323754 18318.306536942368 11392.29554920157 0.6519108853181131 0.521256295526108 1.131059413049522 1.1194890068236258 1.1713290298449257 1.1383246042888875 0.6589613069287623 0.9303701749614974 1.607955697587762 1.0 13.475770859147273 -5.262575224409468 24.84771149933139 1.0818193601675814 0.586583557683328 0.4472626642803873 0.22557557440277615 82.00136844752993 1793915.4625150773 0.05995567154778236 0.1371552842642688 5.462919181334504e-06 5.262575224409468 -0.49523580248425336 T(ph)PQAPASANLVGPR ddPTM_A459_Selumetinib_30min_R2 2 TPQAPASANLVGPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(1)PQAPASANLVGPR;T(1)PQAPASANLVGPR 125.33 0.0032463 14561000.0 10746.2 25273.0 18906.3 15986.0 8054.0 16112.6 24391.0 10842.8 10865.7 9866.6 True False 10148.969224447015 27211.357834496794 17689.889241623016 13808.679222611841 7042.184516326451 18331.964394380062 25525.2298298496 10874.350752877835 13039.143613024315 9581.72562149453 1.0592005683903114 2.839922463804849 1.8462112087555058 1.4411474266842974 0.7349599429698583 1.9132215968756465 2.66394915051515 1.1349052542773277 1.3608345853458603 1.0 13.226069786279254 -11.632172408803644 0.16747592508736173 1.2720632981132755e-10 1.9481329412348116 0.10174690381945406 0.6377267308996225 101.23032004101078 2.361223080993693 41.4085072085867 2.9764675443514834 2.3325318960856063e-12 11.632172408803644 1.9481329411076054 T(ph)PQASTYSYETSDLCYTAEKK ddPTM_A459_Selumetinib_30min_R1 1 TPQASTYSYETSDLCYTAEKK 21 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.997)PQAS(0.002)TYSYETSDLCYTAEKK 156.73 2.2052e-07 9874500.0 806.98 1011.5 1027.3 1005.4 731.8 992.95 983.94 1132.0 501.07 1011.8 True False 825.7810638902619 893.073109766408 887.7983025549753 829.8257636954045 665.6088192097833 982.9618245264658 909.7206136253609 1101.9756827457854 850.2791932951618 1141.674385766599 0.7233069903164863 0.782248529791388 0.7776282919396902 0.726849769111884 0.5830110822385207 0.8609826381157157 0.7968301864060054 0.9652276485171758 0.7447650607701298 1.0 10.156935526410777 -6.9470054299831085 24.99953803748426 0.8673937577221682 0.7254924058785254 0.4482170609170616 0.08568538666313326 97.09335009537595 45802.16035770842 0.029391141383767107 0.025920546235438383 1.1297817889248617e-07 6.9470054299831085 -0.14190135184364283 T(ph)PQASTYSYETSDLCYTAEKK ddPTM_A459_Selumetinib_30min_R2 1 TPQASTYSYETSDLCYTAEKK 21 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.459)PQAS(0.122)T(0.122)Y(0.102)S(0.122)Y(0.073)ETSDLCYTAEKK 92.492 0.00073088 6845200.0 20125.0 20411.0 19052.0 22055.0 27039.0 17807.0 22888.0 20818.0 17361.0 26289.0 True False 19006.53306675813 21976.458068290813 17826.215062249183 19051.070953002883 23642.11908827303 20259.7526141483 23952.337351711587 20878.576933394572 20833.68510686978 25529.968262975053 0.74447930647538 0.8608102384585518 0.6982466597148782 0.7462238400284963 0.9260536027598638 0.7935674813795242 0.9382047445177818 0.8178066152817675 0.8160482180106711 1.0 14.639904123840624 -6.248872642604038 24.478440379196424 0.8712310420617547 0.764881209207764 0.39969159312899494 0.07100018240351377 662.3543558335946 1290182.6883715265 0.020249251017284864 0.02594254023292978 5.638029675059821e-07 6.248872642604038 -0.10634983285399069 T(ph)PQPPAEEPPHPLTYSQLPR ddPTM_A459_Selumetinib_30min_R2 1 TPQPPAEEPPHPLTYSQLPR 20 0 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 T(1)PQPPAEEPPHPLTYSQLPR 81.96700000000001 0.017969 0.0 7011.5 6523.5 5525.9 7235.5 5213.1 4682.7 7562.7 4948.4 4702.4 5091.0 True False 6621.828899258364 7023.83147364143 5170.369610145008 6250.012418066308 4558.18377229469 5327.699419681712 7914.380535205752 4962.799024748283 5643.011396033898 4944.0096019934535 1.339364085496194 1.4206751278980891 1.0457847023719946 1.2641586326099097 0.9219609465274509 1.077607013047376 1.6008020154359384 1.003800442205301 1.1413835834296524 1.0 12.271465829832952 -5.252596171468859 24.49949925202565 1.144100751641645 1.380019635993138 0.22758853350829789 0.18171016695288345 764.7913021694891 2118786.4217810337 0.04668456971276676 0.11941580537209814 5.589897295065614e-06 5.252596171468859 0.235918884351493 T(ph)PQQTSASQQMLNFPDK ddPTM_A459_Selumetinib_30min_R2 3 TPQQTSASQQMLNFPDK 17 0 Q8TAQ2 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 T(0.982)PQQT(0.016)S(0.002)ASQQMLNFPDK;T(1)PQQTSASQQMLNFPDK;T(0.999)PQQT(0.001)S(0.001)ASQQMLNFPDK 151.41 0.00079333 2981800.0 31322.8 30687.4 32545.3 37148.0 36810.0 28538.2 31345.4 34710.0 28448.6 30041.5 True False 29582.00417110316 33041.02490445679 30451.370830643416 32088.37831612564 32185.598714424716 32469.078006013766 32803.023209731764 34811.00035345018 34139.114920298125 29174.123837809162 1.013980894012844 1.1325455766262358 1.043780132007905 1.0998917566305677 1.1032241754150893 1.112940981073591 1.1243876043063754 1.193214937558321 1.1701847537938541 1.0 14.832401708872702 -6.453434327282383 1.1440855897096456 1.1358200833105827 1.069484823374303 0.1292662905230636 0.055990440892829126 0.8092697751013712 2.225018329965801 0.024530979794533583 0.02996651511854062 3.520186497116415e-07 6.453434327282383 -0.06633525993627964 T(ph)PQQTSASQQMLNFPDKGK ddPTM_A459_Selumetinib_30min_R2 1 TPQQTSASQQMLNFPDKGK 19 1 Q8TAQ2 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 T(0.766)PQQT(0.116)S(0.116)AS(0.002)QQMLNFPDKGK 98.572 0.024208 0.0 10567.0 9155.6 11176.0 12508.0 12798.0 11715.0 12683.0 9940.6 5450.3 9649.9 True False 9979.728443052578 9857.805080105996 10456.948327508759 10804.388822496498 11190.200824428357 13328.634911818228 13272.784630887727 9969.525500245085 6540.5122941058935 9371.282313548747 1.0649266673595092 1.0519163493616928 1.1158503156382755 1.1529253373229194 1.194094943468928 1.422285068986562 1.4163253423385072 1.0638379217144502 0.6979314116542832 1.0 13.194030756326798 -8.006845177169906 24.53124577050682 0.8596052749359706 1.2025788468326328 0.5078039160130807 0.13838862008582029 203.66404271922565 729871.3453803165 0.08813240698122474 0.03970725100300701 9.843619611120145e-09 8.006845177169906 0.3429735718966622 T(ph)PQSPAPCVLLR ddPTM_A459_Selumetinib_30min_R1 1 TPQSPAPCVLLR 12 0 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 T(0.957)PQS(0.043)PAPCVLLR 128.57 0.0056899 13184000.0 1250.4 1241.1 1702.9 1759.5 1758.2 1521.9 1618.7 1819.5 1001.4 1471.5 True False 1279.5318871451384 1095.7914350282629 1471.6555333601355 1452.2363549055742 1599.1711204354224 1506.59106777464 1496.6001557771526 1771.2409494310562 1699.3026606377855 1660.3813586237902 0.770625302735078 0.6599637061310489 0.8863358563480377 0.8746402429555477 0.9631348317237782 0.9073765252480192 0.90135928592791 1.0667675472453824 1.0234411822391545 1.0 10.697298924431264 -5.269750092566746 0.4404357632340825 1.0209158970018426 0.5653078729833314 0.7415739554577441 0.058403181849402394 1.7278828820802663 0.35901113922156874 0.047239734279260655 0.39473864074954984 5.373409111869066e-06 5.269750092566746 -0.4556080240185112 T(ph)PQSPTLPPAK ddPTM_A459_Selumetinib_30min_R2 1 TPQSPTLPPAK 11 0 P78310-7;P78310-2;P78310-6;P78310 P78310-7 CXADR Coxsackievirus and adenovirus receptor 1 T(0.651)PQS(0.119)PT(0.23)LPPAK 101.39 0.035834 10485000.0 102030.0 35569.0 64844.0 78809.0 45246.0 27586.0 111760.0 68695.0 50947.0 42643.0 True False 96359.58105845116 38297.02792763882 60672.007636809 68075.07824689212 39561.79297562787 31385.721099224724 116957.06144823873 68894.89107693057 61137.82357811733 41411.78579018012 2.326863698819303 0.9247857149092108 1.465090347569508 1.6438575866253662 0.9553269008024539 0.7578934474897034 2.824245784541185 1.663654193180615 1.4763387381525286 1.0 15.337753796579541 T(ph)PSASNDDQQE ddPTM_A459_Selumetinib_30min_R2 1 TPSASNDDQQE 11 0 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 T(0.853)PS(0.146)AS(0.001)NDDQQE 137.4 0.0031256 3861900.0 12236.0 11338.0 17216.0 14448.0 12696.0 10648.0 12779.0 13286.0 13914.0 14816.0 True False 11555.97210458894 12207.588142583963 16108.341303363513 12480.157475809821 11101.014976319922 12114.665347079852 13373.248821108118 13324.6600603843 16697.188789642663 14388.223583408957 0.8031548882736377 0.8484430389767169 1.119550388550955 0.8673869573587024 0.771534784121682 0.8419847854636661 0.9294579517466489 0.9260809705340518 1.160476044373968 1.0 13.812600862829369 -8.108150627017414 4.906903369757746 1.0780617324779616 0.8868744360003783 0.39165416313407786 0.09659666777171703 0.24542368377976695 8.866755943486858 0.07244889733525917 0.02613881408247666 7.795596877551443e-09 8.108150627017414 -0.19118729647758326 T(ph)PSDDEEDNLFAPPK ddPTM_A459_Selumetinib_30min_R1 2 TPSDDEEDNLFAPPK 15 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 T(0.58)PS(0.42)DDEEDNLFAPPK;T(0.638)PS(0.362)DDEEDNLFAPPK 239.51 1.1072e-19 25363000.0 4183.3 5329.299999999999 4548.0 4863.6 4759.4 4614.5 5264.2 5055.299999999999 2347.0 4603.7 True False 4280.762750715178 4705.3430784756465 3930.4065803757712 4014.263561079139 4328.913110340316 4568.082319630771 4867.117155768265 4921.217022071349 3982.6875819022202 5194.629738835433 0.824074662860354 0.9058091365585031 0.7566288220682531 0.7727718360883761 0.8333439201598998 0.8793855480169168 0.9369516982858931 0.9473662743043973 0.7666932547910692 1.0 12.342805205498438 -6.8188692980051195 3.098887812364799 0.9081738474514879 0.8160909984838796 0.3103990737565462 0.06673276044799102 0.33632604794230847 6.564870538000767 0.024891949566764736 0.0223982514925168 1.5175069962153363e-07 6.8188692980051195 -0.09208284896760832 T(ph)PSFELPDASERPPTYCELVPR ddPTM_A459_Selumetinib_30min_R1 2 TPSFELPDASERPPTYCELVPR 22 1 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 T(0.763)PS(0.236)FELPDAS(0.001)ERPPTYCELVPR;T(0.818)PS(0.182)FELPDASERPPTYCELVPR 126.86 4.0474e-05 68915000.0 857.31 856.81 1158.49 978.74 1216.37 807.28 678.6600000000001 906.6899999999999 208.21 642.67 True False 877.2836549651296 756.4942868798373 1001.1734211300625 807.8214322252234 1106.349548267565 799.1594961515935 627.4681298076993 882.6416358558091 353.3171629432724 725.1629546359162 1.2097745056565787 1.043205919502123 1.380618541983744 1.1139860731451838 1.5256564627229638 1.1020412598887224 0.8652787980912969 1.2171631634147093 0.487224506829176 1.0 9.502161415838364 -7.003655560414603 24.592489024015602 0.9209630019786225 1.2492616460274009 0.39516488758886903 0.21004228182605883 134.40954008398091 904235.7459056219 0.07166788718391912 0.061840875511105835 9.916180868536558e-08 7.003655560414603 0.3282986440487784 T(ph)PSGEFLER ddPTM_A459_Selumetinib_30min_R2 1 TPSGEFLER 9 0 B3KT28;B1ANM7;Q9UNN5-2;Q9UNN5 B3KT28 FAF1 FAS-associated factor 1 1 T(0.931)PS(0.069)GEFLER 108.43 0.028095 3087200.0 8347.8 7054.2 7628.6 11021.0 8166.8 7372.2 8371.2 9995.2 7945.4 8166.8 True False 7883.862694891097 7595.2344571719705 7137.784181391673 9519.920787714567 7140.813571881654 8387.653631831527 8760.477387218107 10024.28437720556 9534.702013024778 7931.003264105309 0.9940561657025707 0.9576637663922061 0.8999850263202333 1.2003425633173663 0.9003669944507586 1.0575778817029313 1.10458627937614 1.263936483619187 1.2022062903665165 1.0 12.953287661637743 -7.279062388773136 2.592977308084143 1.1737672278410052 0.9953180578364511 0.3209679908417278 0.10191877139089664 0.3049136372520901 4.056504913592493 0.04651543449656365 0.030676406454438684 5.2594170656628506e-08 7.279062388773136 -0.17844917000455407 T(ph)PSIDLQR ddPTM_A459_Selumetinib_30min_R2 1 TPSIDLQR 8 0 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 T(0.964)PS(0.036)IDLQR 144.65 0.0048523 3923600.0 12981.0 15959.0 20236.0 14372.0 14534.0 13844.0 13576.0 14772.0 10734.0 14505.0 True False 12259.56798706023 17183.003983727074 18934.037791290895 12414.508806917143 12708.108984391432 15750.885336680461 14207.310900333649 14814.984074363754 12881.09993301885 14086.202961484001 0.8703245310735369 1.2198464008157965 1.3441548331415045 0.8813240048338234 0.9021671077109494 1.1181782187682665 1.008597628415606 1.0517372293209508 0.914447986319644 1.0 13.781995154654492 -5.781408882414073 24.997779783263127 0.9879182185362383 1.1522825446738933 0.24823927883171548 0.1290766860706827 329.94205673020815 413019.49238143436 0.03710493137614557 0.05511377457475603 1.6542118119211148e-06 5.781408882414073 0.16436432613765506 T(ph)PSPAAEDAR ddPTM_A459_Selumetinib_30min_R1 2 TPSPAAEDAR 10 0 Q92797 Q92797 SYMPK Symplekin 1 T(0.998)PS(0.002)PAAEDAR;T(0.992)PS(0.008)PAAEDAR 131.42 0.006111 8933500.0 5763.1 8043.6 5263.1 5355.6 5183.0 5487.4 6666.2 6338.1 3140.3 5329.1 True False 5897.36901695949 7101.851572631807 4548.399928138902 4420.344997062968 4714.1985651329705 5432.201738160557 6163.363167011589 6169.992998949706 5328.859741562646 6013.14189482979 0.980746691181553 1.1810550452398454 0.7564098781786108 0.7351140342894057 0.7839825913947458 0.903388250796354 1.024982159877345 1.0260847169189171 0.8862022275151196 1.0 12.55390328752534 -10.140485280848175 13.237205464055606 0.9999999999999989 0.9189680430255557 0.03201154007946261 0.1322815282366358 0.0 0.0 0.14130716901174756 0.03427202255837894 7.236269271005176e-11 10.140485280848175 -0.08103195697444321 T(ph)PSPAAEDAREPEAK ddPTM_A459_Selumetinib_30min_R1 3 TPSPAAEDAREPEAK 15 1 Q92797 Q92797 SYMPK Symplekin 1 T(0.684)PS(0.316)PAAEDAREPEAK;T(0.873)PS(0.127)PAAEDAREPEAK;T(0.514)PS(0.486)PAAEDAREPEAK 169.98 0.00057656 277252000.0 7609.8 11169.8 8262.5 10136.0 7964.6 8378.6 10470.3 9270.7 4408.14 6733.7 True False 7787.093533906815 9862.034623300862 7140.497882663762 8365.937876284679 7244.203336264337 8294.318891160128 9680.516841313112 9024.810920522403 7480.291622192778 7598.035986792396 1.024882423226615 1.2979715600773616 0.9397820561887349 1.1010658400180153 0.9534310378177829 1.0916398534539813 1.2740814676504133 1.1877820710786522 0.9845033157510319 1.0 12.891410829758465 -7.00986659406202 24.64570048070991 1.1351859936795368 1.0667644578241513 0.019261926770836824 0.12181758105978316 1258.56449759355 3143761.393241873 0.044344302297993195 0.036915466894495305 9.77537453353161e-08 7.00986659406202 -0.06842153585538546 T(ph)PSPAAEDAREPEAK ddPTM_A459_Selumetinib_30min_R2 1 TPSPAAEDAREPEAK 15 1 Q92797 Q92797 SYMPK Symplekin 1 T(0.95)PS(0.05)PAAEDAREPEAK 81.346 0.03801 219780000.0 92093.0 59400.0 86704.0 74704.0 92726.0 62257.0 56661.0 71705.0 52825.0 70556.0 True False 86974.83973748842 63955.788998896394 81125.55903617736 64529.18632841211 81076.9308990422 70832.33663722292 59295.84877164149 71913.64967859826 63391.476053821614 68518.86495349655 1.269356107934915 0.9334040930523718 1.1839886590537791 0.9417725523066937 1.1832789546947218 1.0337640106165873 0.8653944984623624 1.0495452562940986 0.9251682160357607 1.0 16.064213632262593 -7.004053125702723 24.91628141370975 0.9620733985447196 1.0905804753810349 0.2766406309546262 0.107668747547297 227.0779445866026 1395950.2259445218 0.035456948834193557 0.030560831480297115 9.907107473502522e-08 7.004053125702723 0.12850707683631524 T(ph)PSPAPK ddPTM_A459_Selumetinib_30min_R1 1 TPSPAPK 7 0 Q96P11-2;Q63ZY6;Q3KNT7-3;Q63ZY6-6 Q96P11-2 NSUN5;NSUN5P2 Probable 28S rRNA (cytosine-C(5))-methyltransferase;Putative methyltransferase NSUN5C 1 T(0.984)PS(0.016)PAPK 103.83 0.0076966 4338000.0 3644.9 4713.2 5020.3 4176.8 4403.8 4635.2 4007.5 4870.4 3532.2 3991.2 True False 3729.819078259209 4161.376352892766 4338.570834533964 3447.4002882464356 4005.477067554041 4588.574096424871 3705.2110485432413 4741.221170711198 5993.885418319135 4503.509397580206 0.8282027967485289 0.9240296811923447 0.9633755481592057 0.7654919716829655 0.8894123924125119 1.0188885358805673 0.8227386070370142 1.052783674273827 1.3309365850418182 1.0 12.136833956611932 -7.968638741135875 5.366266720842408 1.1753150815864264 0.8936458213007304 0.5574011425290106 0.10124548805663668 0.11595059337137249 8.898778173018966 0.056732856018282554 0.025405208913169885 1.0748831598468702e-08 7.968638741135875 -0.28166926028569594 T(ph)PSPPPPIPEDIALGK ddPTM_A459_Selumetinib_30min_R1 1 TPSPPPPIPEDIALGK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 T(0.752)PS(0.248)PPPPIPEDIALGK 125.36 0.0028343000000000005 5354200.0 1171.7 1609.5 1410.4 1794.9 1258.8 1351.5 1526.9 1319.3 643.61 1188.1 True False 1198.9983302686805 1421.0589917637499 1218.8754267726447 1481.454409445873 1144.94176225919 1337.9051370638172 1411.7247036857582 1284.3078783096416 1092.1591625854646 1340.604208074023 0.8943715997961991 1.0600138230248524 0.9091985684005425 1.1050647167326157 0.8540490588971587 0.9979866757138682 1.053051075912935 0.9580067484307994 0.814676812147646 1.0 10.388667652157359 -8.01394843188228 24.529446659179165 0.9003395156402428 0.9842349022041013 0.1048961450802599 0.08555208657832528 948.095595617245 1667292.3973486752 0.04964306862349026 0.020448992227757073 9.683928363799322e-09 8.01394843188228 0.08389538656385842 T(ph)PSPSPPCSSSPSPSGR ddPTM_A459_Selumetinib_30min_R1 1 TPSPSPPCSSSPSPSGR 17 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.956)PS(0.043)PS(0.001)PPCSSSPSPSGR 134.88 0.0012126 2909900.0 743.96 881.07 990.79 773.49 811.59 915.75 819.24 870.32 892.08 804.54 True False 761.2928205058363 777.9139148016698 856.2461600199006 638.4144917055481 738.1818277978523 906.5383864344739 757.4440672260923 847.2362864022189 1513.7946050546786 907.8105458832371 0.8386031908950241 0.8569121809934618 0.943199177298422 0.7032463927640484 0.8131452439557775 0.998598650947015 0.8343635912371468 0.9332743381802382 1.6675226036087307 1.0 9.826247437694809 -8.095552097172229 7.64120435580264 1.3308807953726904 0.8587358399875914 0.5627073763197263 0.1664143345813042 0.1865346519474338 13.160726200783783 0.10391651732140605 0.038983725383338955 8.025052880308833e-09 8.095552097172229 -0.47214495538509904 T(ph)PSSEEISPTK ddPTM_A459_Selumetinib_30min_R1 1 TPSSEEISPTK 11 0 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.502)PS(0.249)S(0.249)EEISPTK 185.3 4.7488e-05 21353000.0 4032.6 5190.6 3465.4 3974.5 3443.7 3745.6 4331.8 3930.8 1945.7 3700.3 True False 4126.551733926332 4582.882138955524 2994.817714079638 3280.428185605115 3132.2179430346173 3707.922664732695 4005.048838447814 3826.5424149621335 3301.710791694567 4175.269548974254 0.9883318155926268 1.0976254551233486 0.7172752989840813 0.7856805763381249 0.7501834088302431 0.8880678531625886 0.9592312044695993 0.9164779351556375 0.7907778774440334 1.0 12.027653623426145 -5.2473427601968154 24.99596864993536 0.8472401204377032 1.042978651462596 0.4191443283553016 0.09033236150857682 781.9433451037298 1386527.564291527 0.02394599823364781 0.0626775132417398 5.657925697512862e-06 5.2473427601968154 0.1957385310248928 T(ph)PSSEEISPTK ddPTM_A459_Selumetinib_30min_R2 1 TPSSEEISPTK 11 0 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.408)PS(0.296)S(0.296)EEISPTK 167.84 0.0012009 47313000.0 126560.0 92906.0 118970.0 129790.0 128870.0 109700.0 127140.0 132760.0 104520.0 116770.0 True False 119526.30185982159 100031.59146012561 111315.59972474226 112112.37809976174 112680.19848758244 124810.17924254897 133052.2619231307 133146.30962039885 125426.92053280507 113398.54669510428 1.0540373341925895 0.882124104545021 0.9816316255272437 0.9886579799051511 0.9936652785378876 1.1006329699985244 1.1733154065974896 1.1741447619993806 1.1060716754161022 1.0 16.79104262539419 -6.769049875547065 3.161297539543096 1.129305495813657 0.9720341539253078 0.5353542152900275 0.06036604701744757 0.1682175589805179 3.483180229514782 0.02126177990848318 0.01969932426986302 1.7019630391553587e-07 6.769049875547065 -0.15727134188834924 T(ph)PSSEEISPTKFPGLYR ddPTM_A459_Selumetinib_30min_R1 2 TPSSEEISPTKFPGLYR 17 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.827)PS(0.164)S(0.009)EEISPTKFPGLYR;T(0.497)PS(0.497)S(0.006)EEISPTKFPGLYR 116.43 0.0033894 218085000.0 2002.74 2332.8199999999997 3298.9 3763.1 2873.65 2333.07 2614.9 2313.3 1428.49 1810.29 True False 2049.3999453463325 2059.692349901404 2850.9274995606033 3105.9452271356427 2613.728864884116 2309.6014340580705 2417.6559877319314 2251.943769342602 2424.043197218364 2042.6583552178454 1.003300400241316 1.0083391305452754 1.3956947290172554 1.5205407302702854 1.2795722095217275 1.1306841538910974 1.183583138881829 1.1024573755029323 1.1867100491995124 1.0 10.996232210980045 -6.7698525940964105 22.979613921391515 1.1310214599946433 1.2526064567713258 0.12895143759707794 0.1544852173760354 170.5207110378861 465748.32570573647 0.06064319256088228 0.054467722927611165 1.698820159045117e-07 6.7698525940964105 0.12158499677668244 T(ph)PSSEEISPTKFPGLYR ddPTM_A459_Selumetinib_30min_R2 1 TPSSEEISPTKFPGLYR 17 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.476)PS(0.476)S(0.047)EEISPTKFPGLYR 85.054 0.016523 12915000.0 23202.0 22864.0 25360.0 31224.0 30005.0 19330.0 22602.0 18517.0 14463.0 23987.0 True False 21912.52572496507 24617.59528065265 23728.365209880278 26971.237335595662 26235.50365189659 21992.53203973082 23653.037785013337 18570.881404345633 17356.004129984318 23294.43298428934 0.940676501537673 1.0568016528779947 1.0186281514507607 1.157840474322174 1.1262563750571144 0.9441110695659959 1.0153944421384222 0.7972240155779087 0.7450708992011041 1.0 14.507697593416736 -7.696575375615668 5.004032152217321 0.8282724750613032 1.0439196625914022 0.485377123671342 0.08887724825500815 0.15534547125677675 7.480475282380434 0.04488649978853155 0.02462086733437481 2.0110581311363087e-08 7.696575375615668 0.21564718753009904 T(ph)PSSPSKSPASFEIPASAMEANGVDGDGLNKPAK ddPTM_A459_Selumetinib_30min_R1 1 TPSSPSKSPASFEIPASAMEANGVDGDGLNKPAK 34 2 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0YA73 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 T(0.468)PS(0.063)S(0.231)PS(0.125)KS(0.109)PAS(0.004)FEIPASAMEANGVDGDGLNKPAK 80.098 5.4615e-06 79224000.0 3212.8 3579.2 5068.5 5047.5 3237.8 3338.8 4268.0 3771.7 2095.3 2928.7 True False 3287.6519889794486 3160.1456000750627 4380.225539277614 4166.048878309683 2944.9415616800197 3305.2147033878464 3946.061323813487 3671.662263791767 3555.571065342872 3304.6271729537834 0.9948632075311655 0.9562790096077378 1.3254825158876926 1.2606713738863111 0.8911569770358497 1.000177790232699 1.1941018206560254 1.111067019554256 1.0759371267182272 1.0 11.690271801154196 T(ph)PSSPSKSPASFEIPASAMEANGVDGDGLNKPAK ddPTM_A459_Selumetinib_30min_R2 1 TPSSPSKSPASFEIPASAMEANGVDGDGLNKPAK 34 2 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0YA73 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 T(0.345)PS(0.244)S(0.224)PS(0.14)KS(0.044)PAS(0.003)FEIPASAMEANGVDGDGLNKPAK 77.02600000000002 9.4791e-06 9436800.0 17346.0 19331.0 17003.0 20432.0 19085.0 12495.0 13461.0 16077.0 14226.0 19674.0 True False 16381.978761539698 20813.625541038145 15909.045491466664 17649.126352834046 16687.371677935233 14216.072831683212 14086.963172465477 16123.781408309378 17071.59750765104 19105.96050080913 0.8574276472960324 1.0893786543815316 0.8326744677815555 0.9237497561081324 0.8734118170729248 0.7440648079996379 0.7373072487964633 0.8439136785416541 0.8935220768894641 1.0 14.22173516668335 -5.819974950119717 1.3879619596959811 0.8315384583529772 0.9616526578899893 0.12722352097537437 0.09493707124002186 0.6799993388574507 2.644465736841245 0.032014070556331105 0.07126460973308987 1.5136485523811578e-06 5.819974950119717 0.1301141995370121 T(ph)PSSQNLLALLAR ddPTM_A459_Selumetinib_30min_R1 1 TPSSQNLLALLAR 13 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.79)PS(0.207)S(0.003)QNLLALLAR 177.63 0.00024443 23621000.0 505.32 463.32 514.03 631.87 558.65 682.22 514.94 398.6 288.7 296.19 True False 517.0929728184435 409.07427900837575 444.2275493646783 521.5257661689029 508.12020613766805 675.3574862061988 476.0976612194277 388.02783316472625 489.90281418626745 334.2088716349169 1.5472149805266258 1.2240078397896044 1.3291913742192447 1.5604785223613313 1.5203671992667163 2.02076468797018 1.4245512361488337 1.1610339105198864 1.4658581975688172 1.0 8.384606220282805 -8.663290730058618 0.9667190364814672 1.014916080150462 1.5039245986007628 0.30207457911837166 0.2208527014105742 1.0045727663250985 1.9668717576675252 0.22836453975505713 0.07591815400427122 2.1712471927205106e-09 8.663290730058618 0.4890085184503008 T(ph)PSSQNLLALLAR ddPTM_A459_Selumetinib_30min_R2 1 TPSSQNLLALLAR 13 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.874)PS(0.124)S(0.002)QNLLALLAR 120.29 0.0071658999999999985 47258000.0 12966.0 2783.1 3779.7 12727.0 12077.0 5606.6 11681.0 10763.0 3420.2 6212.9 True False 12245.40162701048 2996.554820923041 3536.518217026201 10993.560644700423 10559.779290250139 6378.858258352545 12224.189645462393 10794.31854808943 4104.335568372563 6033.517433947187 2.0295626491625827 0.4966513901266156 0.5861453548021947 1.8220815245922521 1.7501862563346944 1.057237064148074 2.0260469583934237 1.7890589803148509 0.6802558562737866 1.0 12.558783597737401 -5.766522001278635 24.999962090764907 1.4998803571743333 0.983372963538102 0.09329016544263846 0.5597982959311228 235.4276761993023 1158008.775022407 0.15438678482122276 0.23710570499963415 1.7118984500452468e-06 5.766522001278635 -0.5165073936362313 T(ph)PSSSPPIT(ph)PPASETK ddPTM_A459_Selumetinib_30min_R2 1 TPSSSPPITPPASETK 16 0 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 2 T(0.533)PS(0.062)S(0.377)S(0.028)PPIT(1)PPASETK 125.96 0.0067333 0.0 30734.0 27814.0 30783.0 35149.0 32955.0 25299.0 25080.0 28010.0 23281.0 26893.0 True False 29025.927317950012 29947.244363894006 28802.45529399623 30361.64556459299 28814.898278562003 28783.70760854369 26246.269695077197 28091.504462694884 27937.850525490205 26116.529213594575 1.111400641354786 1.1466778038907792 1.102843913846084 1.1625451956605581 1.1033203548181598 1.1021260663365924 1.0049677535794108 1.075621658335529 1.069738260279531 1.0 14.672675560543865 -7.024032800966815 3.2325045773292382 1.0439136153367574 1.1269461385410653 0.6686314902461412 0.028970088901930154 0.1563603599044246 3.348849703544719 0.011161491952365356 0.008923569469706216 9.461656975941659e-08 7.024032800966815 0.08303252320430787 T(ph)PSSSSTLAYSPR ddPTM_A459_Selumetinib_30min_R1 1 TPSSSSTLAYSPR 13 0 H3BR17;Q6Q0C0;A0A087WUB0 H3BR17 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 T(0.948)PS(0.051)S(0.001)SSTLAYSPR 178.22 0.00024821 12241000.0 599.11 674.46 693.45 785.93 667.63 753.21 853.83 705.12 426.33 670.78 True False 613.0680973348717 595.493909652053 599.2832988481917 648.6820792332695 607.24298437965 745.6333912599617 789.4249156775236 686.4179270474455 723.4508720887823 756.8811469505035 0.8099925593403154 0.786773342223301 0.7917799264292972 0.8570461582334674 0.8022963536960194 0.985139336954211 1.0429971982498702 0.9069031905643885 0.9558315397385536 1.0 9.56392296136319 -6.761216141625978 24.99984613913092 0.976407156411517 0.8099591173579348 0.8406686094484757 0.0366950156671324 2.4298988227672065 272128.3632465331 0.013132954314155593 0.012358611396002637 1.7329413250899816e-07 6.761216141625978 -0.1664480390535822 T(ph)PSTASLTGTPPTASLTR ddPTM_A459_Selumetinib_30min_R1 1 TPSTASLTGTPPTASLTR 18 0 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 T(0.979)PS(0.02)TASLTGTPPTASLTR 181.81 2.4013e-09 7514500.0 657.4 1130.0 1036.8 1326.5 637.76 913.11 926.5 830.29 463.44 729.13 True False 672.7161409222758 997.6990746772518 896.0082547347403 1094.8516764889139 580.0747206056734 903.9249424375461 856.6133590705707 808.2680120379841 786.4238316816206 822.7209378276349 0.8176723236174815 1.2126822459528506 1.0890791926368348 1.3307691905591104 0.7050686252586933 1.0987017600698572 1.0411955253411047 0.9824327726144746 0.9558816307241974 1.0 9.68425934960204 -6.247279242479255 24.99652627033554 0.973608531029382 1.1180264163441207 0.17989935187938677 0.15449543875372307 1464.810274158945 2585791.4171171733 0.04439228580571596 0.057024988520357194 5.658753257666475e-07 6.247279242479255 0.14441788531473865 T(ph)PSYSISSTLNPQAPEFILGCTASK ddPTM_A459_Selumetinib_30min_R1 1 TPSYSISSTLNPQAPEFILGCTASK 25 0 Q14694;Q14694-3;Q14694-2;H3BQC6 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 T(0.462)PS(0.462)Y(0.001)S(0.055)IS(0.009)S(0.006)T(0.006)LNPQAPEFILGCTASK 67.788 0.00232 12036000.0 1185.1 1870.0 2052.2 2244.1 1502.1 1548.5 1551.3 1629.0 1000.7 1743.5 True False 1212.7105241968202 1651.0595306605856 1773.5225119276945 1852.2100619741955 1366.2353202172949 1532.923495925506 1434.2841920412038 1585.7936282622657 1698.1148117637629 1967.2952081281528 0.6164354587894784 0.8392535720307782 0.9015029897903174 0.9415008252556774 0.6944739734903559 0.7792035936406595 0.7290640398630871 0.8060781227496207 0.8631723417755334 1.0 10.941997746267573 -8.63164514601025 2.2310722068792583 0.9995451116000782 0.7934873806003196 0.3403571160416997 0.09017679646236476 0.5728997500698397 6.1560112044838124 0.09035347569705539 0.024760838641701345 2.3353654668574088e-09 8.63164514601025 -0.20605773099975855 T(ph)PT(ph)T(ph)ILLT(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 TPTTILLTPER 11 0 A0A6I8PIW1;O43301;A0A6I8PIU5;A0A6I8PIT5;A0A6I8PLB1;A0A1B0GTF3;A0A6I8PL68 A0A6I8PIW1 HSPA12A Heat shock 70 kDa protein 12A 4 T(1)PT(1)T(1)ILLT(1)PER 63.602 0.037464 0.0 1027.5 1413.7 1352.9 1089.6 543.97 1273.9 1049.5 785.24 473.06 510.23 True False 1051.4387508330371 1248.1833467887009 1169.1836109477533 899.3218143251564 494.76800954570353 1261.0857226086553 970.3353700427026 764.4128843810074 802.7482690646196 575.7229905610711 1.8262927971807361 2.1680276230974953 2.0308093130141023 1.56207382555406 0.859385533767771 2.1904383588705802 1.6854205684873933 1.3277442397011945 1.394330749727922 1.0 9.169231014859074 -1.5228789310265693 0.07816206563575866 0.43083070835405124 4.691776435937432 0.37039637639210465 0.3496291466387767 236.5866396110203 1.3566558652717908 11.472837889680484 109.1817377684628 0.029999987169107612 1.5228789310265693 4.260945727583381 T(ph)PTAPAVNLAGAR ddPTM_A459_Selumetinib_30min_R1 2 TPTAPAVNLAGAR 13 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(1)PTAPAVNLAGAR;T(1)PTAPAVNLAGAR 136.33 0.0025718000000000004 36828000.0 978.1800000000001 1090.08 1072.72 949.98 1336.42 865.4200000000001 988.5799999999999 1062.01 693.11 949.22 True False 1000.9696907930521 962.4529268355567 927.0505160291763 784.0838263331613 1215.5410469641156 856.7146605384903 914.0106146896762 1033.8420449053456 1176.157047248507 1071.0616331857789 0.9345584416237146 0.8985971460604232 0.8655435759301225 0.7320622847827839 1.1348936506563077 0.7998742873370113 0.8533688317926503 0.9652498165117475 1.098122657750452 1.0 10.064825785602807 -8.002898856334749 4.616862024170958 1.046648299725552 0.8885515581768773 0.28934034524743646 0.10098627352141165 0.23945188717456936 13.344735115808444 0.06422498898870517 0.026074856135947313 9.933473640349778e-09 8.002898856334749 -0.1580967415486747 T(ph)PTAPAVNLAGAR ddPTM_A459_Selumetinib_30min_R2 2 TPTAPAVNLAGAR 13 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(0.999)PT(0.001)APAVNLAGAR;T(0.999)PT(0.001)APAVNLAGAR 136.33 0.0025718000000000004 34721000.0 6591.0 7057.4 13014.2 14578.599999999999 12301.0 6064.2 13715.099999999999 10534.900000000001 8793.1 7749.6 True False 6224.698605863489 7598.679886882353 12176.880540789585 12592.969530512262 10755.638407664725 6899.488504673338 14352.879325955078 10565.554814853414 10551.965699741768 7525.848912121092 0.8271091645007679 1.0096774431179396 1.618007574026309 1.6732955547685913 1.429159491940072 0.9167721256748934 1.9071442296480876 1.4039020631727788 1.4020964043998847 1.0 12.877638611016907 -5.1087536837579055 4.607586151881375 1.4408239472746605 0.8656238475355142 0.34441622027007557 0.27910848189560156 0.22094982341637992 7.319709571231423 0.0706790595681431 0.21004938348909788 7.78477950606814e-06 5.1087536837579055 -0.5752000997391462 T(ph)PTDPGLDSALEPSGDPHGK ddPTM_A459_Selumetinib_30min_R2 2 TPTDPGLDSALEPSGDPHGK 20 0 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 T(0.974)PT(0.026)DPGLDSALEPSGDPHGK;T(0.957)PT(0.043)DPGLDSALEPSGDPHGK 208.72 1.3553e-16 15135800.0 188688.0 148413.0 175575.0 182715.0 206117.0 166367.0 205329.0 217320.0 232800.0 251180.0 True False 178201.4763379108 159795.79987699038 164278.69565160648 157828.90179904425 180222.73975064053 189282.54412073977 214877.20535169466 217952.36522073718 279366.504975479 243927.78075598401 0.7305501480217897 0.6550947144345316 0.6734726776198755 0.6470312701156833 0.7388364670563229 0.7759778059477808 0.8809050149423102 0.8935118605402652 1.145283674166439 1.0 17.89609454940777 -7.508602024156657 0.998309450819299 1.0601380637246947 0.676881447784135 0.8798415631514787 0.05393322106202985 0.16770996800596874 0.3095644534880971 0.04207129980263282 0.019911989074223122 3.100258992299281e-08 7.508602024156657 -0.3832566159405597 T(ph)PTPEPAEVETR ddPTM_A459_Selumetinib_30min_R1 2 TPTPEPAEVETR 12 0 F8W6G1;Q9UHY1 F8W6G1 NRBP1 Nuclear receptor-binding protein 1 T(0.948)PT(0.052)PEPAEVETR;T(0.975)PT(0.025)PEPAEVETR 154.23 0.001047 105844000.0 2317.63 3370.4 3967.3 4025.2 2806.8999999999996 2658.5 2877.0 2372.2799999999997 1638.52 1941.7599999999998 True False 2371.6262696770527 2975.7920011435485 3428.562450818996 3322.2743823619844 2553.016390598443 2631.7579037248706 2659.9855737140115 2309.359428148562 2780.448767234095 2191.0038103440897 1.0824382223710496 1.3581865933296622 1.564836370722948 1.5163252417348523 1.1652268145519566 1.2011653705483798 1.2140488123095823 1.0540189009465415 1.2690296356889654 1.0 11.097376277963177 -6.285943549383217 22.439862771085274 1.1589849634872516 1.3920272612420403 0.39156046944278555 0.13984192715914145 229.23457266470837 209922.00927590323 0.04501892062253472 0.051087856832610724 5.17674116075065e-07 6.285943549383217 0.2330422977547888 T(ph)PTPSTPGDTQPNTPAPVPPAEDGIK ddPTM_A459_Selumetinib_30min_R2 1 TPTPSTPGDTQPNTPAPVPPAEDGIK 26 0 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YD40;A0A2R8YDW2;A0A2R8Y5M9;A0A2R8YE38;A0A2R8Y4X2;A0A2R8Y7M9 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 T(0.757)PT(0.21)PS(0.016)T(0.016)PGDT(0.002)QPNTPAPVPPAEDGIK 81.446 0.0021614 0.0 11221.0 8077.0 13491.0 13432.0 15319.0 12082.0 14103.0 15472.0 12287.0 13138.0 True False 10597.38174122201 8696.479928351619 12623.003747890174 11602.538428507582 13394.490266402392 13746.185830523935 14758.81744456434 15517.020958472518 14744.743327464383 12758.671803376552 0.8306022683660096 0.6816132636980377 0.989366600412868 0.9093845039134087 1.0498342204286164 1.0773994379952654 1.1567675438330858 1.2161940676588276 1.1556644417769428 1.0 13.639190529779407 -5.900113531902335 0.8139167894241387 1.1486798277093644 0.737193997698201 0.7353112105655336 0.08002835865798268 0.36917492774002425 0.4685434752904666 0.03712569805722767 0.10319494923687385 1.2585963504715837e-06 5.900113531902335 -0.41148583001116334 T(ph)PTQPLLESGFR ddPTM_A459_Selumetinib_30min_R2 1 TPTQPLLESGFR 12 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 T(0.999)PT(0.001)QPLLESGFR 120.9 0.0091667 2553900.0 1273.0 1873.7 900.92 2771.4 1568.5 526.63 1055.0 2796.9 1500.3 2326.6 True False 1202.2517562227615 2017.4067651049188 842.9557880475295 2393.9305390683394 1371.4510074320879 599.1685022288375 1104.0595904428405 2805.038515948278 1800.4019218844956 2259.42501276723 0.5321051813754616 0.8928850276974232 0.3730842065057604 1.0595308653932152 0.6069911591145943 0.2651862747571366 0.48864626363087127 1.241483342044093 0.796840750062979 1.0 11.141739961385957 -7.752117176034205 24.99732155444615 1.0143715614321462 0.6097293832640716 0.37949521433620736 0.2402102782714973 205.4249273888774 550846.9658908821 0.11610976672309312 0.06587019021074438 1.7696314335548435e-08 7.752117176034205 -0.4046421781680747 T(ph)PTQTNGSNVPFKPR ddPTM_A459_Selumetinib_30min_R2 2 TPTQTNGSNVPFKPR 15 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 T(0.478)PT(0.478)QT(0.043)NGSNVPFKPR;T(0.94)PT(0.056)QT(0.004)NGSNVPFKPR 88.28299999999999 0.024621 10650000.0 50158.0 50705.0 62572.0 71755.0 58331.0 48749.0 62090.0 56639.0 48293.0 51848.0 True False 47370.419158382785 54593.910457728 58546.18564324245 61981.84521572084 51002.938294243664 55463.73225063828 64977.30802900095 56803.81011290878 57952.9494191615 50351.01352271788 0.940803686841571 1.0842663660205323 1.1627608174526016 1.2309949865806622 1.0129475997783368 1.101541525586443 1.2904865956607572 1.128156240336244 1.1509788058787278 1.0 15.619733198287614 -4.811261482760558 2.7949937102415197 1.1423357846447213 0.9110548973763524 0.326295414464566 0.08325600918006648 0.45255353580110697 5.118011123820558 0.021384960444573723 0.23643230449657202 1.544324343027539e-05 4.811261482760558 -0.23128088726836893 T(ph)PTSSPASSPLVAK ddPTM_A459_Selumetinib_30min_R1 2 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 T(0.845)PT(0.005)S(0.003)S(0.006)PAS(0.132)S(0.009)PLVAK;T(0.744)PT(0.248)S(0.004)S(0.004)PASSPLVAK 208.51 1.3856e-05 14424000.0 5887.1 6601.6 7450.7 7451.0 6100.299999999999 6414.0 6143.8 6808.6 3533.1000000000004 5222.7 True False 6024.257975697492 5828.681602999424 6438.935863765551 6149.8227225924575 5548.5289420954405 6349.4809834460475 5680.368219598243 6628.013810550312 5995.412652585741 5893.084418406027 1.0222588966962305 0.9890714588772135 1.0926257637943642 1.0435660319720779 0.9415322347607261 1.0774461271273401 0.9639040978026037 1.124710480957792 1.0173641215557865 1.0 12.524807217599173 -7.74455457997286 24.99929732342569 1.0532780540946869 1.0205944625147398 0.052942623403209876 0.053516709834711886 649.6846106022356 961912.9972237692 0.02424735317480305 0.013954885147975474 1.800716815077725e-08 7.74455457997286 -0.03268359157994705 T(ph)PTSTPVHVK ddPTM_A459_Selumetinib_30min_R2 2 TPTSTPVHVK 10 0 Q9ULM3 Q9ULM3 YEATS2 YEATS domain-containing protein 2 1 T(0.992)PT(0.004)S(0.003)T(0.001)PVHVK;T(0.856)PT(0.125)S(0.019)TPVHVK 117.25 0.0082455 8468000.0 82614.0 76295.0 96526.0 102519.0 97313.0 85175.0 96171.0 94154.0 82451.0 93429.0 True False 78022.64461004497 82146.58117290893 90315.62224956241 88555.73534486069 85087.67095074196 96907.08310833278 100643.14205922118 94427.9725519663 98943.50387342414 90731.4620123052 0.8599293219750318 0.9053814338599331 0.9954168074279858 0.9760201520047209 0.9377967582976033 1.0680648251340867 1.1092419302752086 1.0407412209356857 1.0905093082265687 1.0 16.469315285523678 -5.180742368069505 0.5115580033831683 1.0672475866203464 0.7796816729995201 0.6860617315285888 0.043193282702132046 1.8163340951426312 0.4891916290486004 0.030019206616794324 0.2986708620961178 6.5956504602271155e-06 5.180742368069505 -0.2875659136208263 T(ph)QLSPSIK ddPTM_A459_Selumetinib_30min_R1 1 TQLSPSIK 8 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.865)QLS(0.132)PS(0.003)IK 111.27 0.027296 10630000.0 5390.0 7542.4 4448.6 5006.9 4894.1 5316.0 5844.5 5800.3 2724.1 5256.4 True False 5515.576512885712 6659.332301633364 3844.504554410651 4132.538906153292 4451.429519123536 5262.525866541809 5403.6446595660545 5646.457201970299 4622.598739607939 5931.110141671822 0.9299399911887352 1.122780077012071 0.6481930806510007 0.696756392554268 0.7505221472533297 0.8872750194887534 0.9110680008452703 0.9520068026217287 0.7793817058175473 1.0 12.534086447778693 -10.041309474810664 15.142996242057407 0.9999999999999976 0.8530109168448392 0.0997220382674403 0.13241199053839525 0.0 0.0 0.1376813091406735 0.03339262236825384 9.092651066019276e-11 10.041309474810664 -0.14698908315515835 T(ph)QQSPISNGSPELGIK ddPTM_A459_Selumetinib_30min_R2 1 TQQSPISNGSPELGIK 16 0 Q15723-2;Q15723-3;Q15723-1;Q15723 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 T(0.519)QQS(0.349)PIS(0.118)NGS(0.014)PELGIK 95.073 0.020793 6708700.0 28956.0 28922.0 30316.0 38407.0 33165.0 24221.0 25506.0 26430.0 20435.0 28176.0 True False 27346.74144005207 31140.224401112482 28365.50156556507 33175.900344229514 28998.51620113816 27557.222893653387 26692.0795391802 26506.90692427796 24522.571001606124 27362.48566996024 0.9994246052753367 1.1380627029546375 1.0366566074333659 1.212459304479472 1.059791005499695 1.007116942007463 0.9754990778664512 0.9687316877566583 0.8962113785052832 1.0 14.739911673400341 -6.874930792669366 2.2118271770260236 0.957896989388753 1.0982710517023422 0.5234310239896618 0.05893380974194491 0.23754342159394443 2.373072455380798 0.023442873257360296 0.020061205024988774 1.3337339534278784e-07 6.874930792669366 0.14037406231358918 T(ph)QSAPLPQNAQALQHLVIQQQHQQFLEK ddPTM_A459_Selumetinib_30min_R1 2 TQSAPLPQNAQALQHLVIQQQHQQFLEK 28 0 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 T(0.743)QS(0.257)APLPQNAQALQHLVIQQQHQQFLEK;T(0.526)QS(0.474)APLPQNAQALQHLVIQQQHQQFLEK 77.783 0.00011409 16916000.0 1704.71 1908.23 1831.8600000000001 1688.26 1645.52 1602.5500000000002 1715.76 1546.52 792.8 1573.11 True False 1744.4264262117642 1684.81354448794 1583.103473686711 1393.437083565151 1496.683006540152 1586.4298019989808 1586.3388418336997 1505.5012657950645 1345.3236961789855 1775.0339918890056 0.9827566312436257 0.9491725522928987 0.8918722012765284 0.7850199432419003 0.8431855465186725 0.8937461531712355 0.8936949089890414 0.8481534847639158 0.7579143285854943 1.0 10.793630937144274 -5.290091774597327 2.946652728768414 0.8552974026069007 0.9730139342035625 0.30588225729481466 0.06254063812773637 0.29462661982809746 5.07437388617036 0.016481863495303374 0.046878198980020776 5.127530181792905e-06 5.290091774597327 0.11771653159666184 T(ph)QSAPLPQNAQALQHLVIQQQHQQFLEK ddPTM_A459_Selumetinib_30min_R2 1 TQSAPLPQNAQALQHLVIQQQHQQFLEK 28 0 P56524-2;P56524 P56524-2 HDAC4 Histone deacetylase 4 1 T(0.578)QS(0.422)APLPQNAQALQHLVIQQQHQQFLEK 72.57600000000002 0.00035543 3779500.0 6772.6 6162.2 8600.8 8811.3 8054.7 6949.6 6658.2 6771.1 4043.3 7683.2 True False 6396.206004865894 6634.820925404036 8047.433891842995 7611.1857396596815 7042.7965760683755 7906.844317812378 6967.819492973009 6790.80277998405 4852.072979241209 7461.366052649007 0.8572432929483538 0.8892233511380234 1.0785469892588793 1.0200793910865 0.9439017636144488 1.0597046522071134 0.933853056371524 0.9101286188168068 0.650292847851712 1.0 12.865224072912186 -8.018799276244122 11.210521137522571 0.8101284057521302 0.9708626165866889 0.23512771151350198 0.10255779094192605 0.8693626960429268 509.39093154096236 0.06313272888689682 0.02571352146378378 9.576365728783806e-09 8.018799276244122 0.16073421083455874 T(ph)QSPEFEAQSSK ddPTM_A459_Selumetinib_30min_R2 1 TQSPEFEAQSSK 12 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 T(0.843)QS(0.157)PEFEAQSSK 159.41 0.0010832 6040500.0 28139.0 20443.0 20160.0 20910.0 23505.0 18511.0 21603.0 20657.0 19805.0 19925.0 True False 26575.147029341937 22010.912365394594 18862.92754854837 18062.021928238068 20552.091762633867 21060.722223872588 22607.582305532407 20717.108450049545 23766.553397935386 19349.713478632813 1.3734129478810064 1.1375316947044434 0.9748427318770387 0.9334516476527316 1.0621393327259754 1.088425533904116 1.1683678071252652 1.0706674531861518 1.2282638409183644 1.0 14.24002458333433 -4.80094163476359 3.5495338016116533 1.0672818635555037 1.4026369259377167 0.555434369764118 0.08246846675361794 0.2126204917029742 4.505376493081173 0.022285780011012016 0.18570484231149328 1.5814605589343945e-05 4.80094163476359 0.335355062382213 T(ph)QSPGGCSAEAVLAR ddPTM_A459_Selumetinib_30min_R2 3 TQSPGGCSAEAVLAR 15 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7 Q96MH2 HEXIM2 Protein HEXIM2 1 T(0.976)QS(0.024)PGGCSAEAVLAR;T(0.84)QS(0.16)PGGCSAEAVLAR;T(0.879)QS(0.121)PGGCSAEAVLAR 173.09 8.1055e-05 198847500.0 103390.0 107130.0 111816.0 113475.0 117937.0 87124.0 97731.0 92808.0 91174.0 106033.0 True False 97643.99770296253 115346.52652275685 104621.88029605588 98019.5092447066 103120.69968984264 99124.54016707234 102275.68515030261 93078.05591480841 109411.34761440833 102971.55178318045 0.9482618841033322 1.120178578697478 1.0160270335281574 0.9519086344459391 1.0014484379819413 0.9626400539810406 0.9932421467791117 0.9039201051451178 1.0625395628181624 1.0 16.651886289804438 -5.529823985538539 20.38213962228879 0.9790876963353927 1.0426908008053626 0.1299745968265329 0.05448161051332362 24.885096459853507 73029.04116454162 0.0136526400623838 0.023794075789700976 2.9524055595768284e-06 5.529823985538539 0.06360310446996986 T(ph)QTPPLGQTPQLGLK ddPTM_A459_Selumetinib_30min_R1 1 TQTPPLGQTPQLGLK 15 0 P78344-2;P78344;H0Y3P2;D3DQV9;E9PKF8 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 T(0.62)QT(0.38)PPLGQTPQLGLK 196.45 7.348399999999999e-05 503500000.0 3764.1 4293.2 4482.1 4150.0 3401.2 3358.0 3601.3 3673.9 1817.6 3054.2 True False 3851.7962063363843 3790.5501481454694 3873.4554384129815 3425.2804051481266 3093.562060530633 3324.2215688200517 3329.6510415767375 3576.4562374909397 3084.3344477483897 3446.236320427305 1.1176819719254751 1.0999101035751002 1.123966866535927 0.993919187968926 0.897663936217542 0.9645947810125439 0.9661702599559069 1.037786125197441 0.8949863448035268 1.0 11.750805920240794 -5.838109475839723 4.532869719782149 0.9614670204389135 1.112773565961752 0.7423880626305522 0.040486035787682194 0.1016724085077264 3.8807527393638965 0.011375930168110735 0.01763982626633241 1.4517456191454506e-06 5.838109475839723 0.1513065455228384 T(ph)QTPPLGQTPQLGLK ddPTM_A459_Selumetinib_30min_R2 2 TQTPPLGQTPQLGLK 15 0 P78344-2;P78344;H0Y3P2;D3DQV9;E9PKF8 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 T(0.607)QT(0.39)PPLGQT(0.003)PQLGLK;T(0.835)QT(0.165)PPLGQTPQLGLK 161.94 0.00027139 35978000.0 83848.0 73044.0 90860.0 95505.0 97836.0 64895.0 73344.0 79767.0 51472.0 69903.0 True False 79188.06383013839 78646.23992652162 85014.16652088807 82497.05424468558 85544.96701506265 73833.6971918434 76754.64132837881 79999.10876386226 61767.838247842985 67884.71876019401 1.1665079457701517 1.158526416001563 1.2523314241192434 1.2152522062602975 1.260150569633415 1.0876335431640285 1.130661549906662 1.178455331699361 0.9098931155042537 1.0 16.05079923163271 -8.25387707851574 24.874360410838268 0.9549465524115355 1.1817704303116494 0.7414260432910385 0.0534425362891336 247.8580344390244 815276.3122174949 0.040071354001661744 0.014492335143360348 5.573434755337125e-09 8.25387707851574 0.22682387790011393 T(ph)QTPPVEENVTQK ddPTM_A459_Selumetinib_30min_R1 1 TQTPPVEENVTQK 13 0 Q6P1Q9-2;Q6P1Q9 Q6P1Q9-2 METTL2B Methyltransferase-like protein 2B 1 T(0.553)QT(0.436)PPVEENVT(0.011)QK 126.63 0.004696199999999999 8287900.0 1978.5 2082.7 2864.4 2596.0 1894.0 1906.8 2102.2 1936.3 1152.0 1639.4 True False 2024.5952005091633 1838.8565157790385 2475.4302130229466 2142.657332955311 1722.688034412859 1887.6193232358764 1943.6293615090708 1884.9430340111871 1954.8598612489793 1849.832959108286 1.094474606769425 0.9940662516173683 1.3381912138792416 1.1582977384012993 0.9312668075950395 1.020426906084431 1.0507053363596675 1.0189801326276648 1.0567764249326175 1.0 10.853179285162327 -6.238328276289432 24.346758159313733 1.0162289586751256 1.149096232239975 0.3673739325542027 0.08555656535341945 674.6586945664533 710729.194476924 0.026348324213315517 0.033989619690276265 5.776592389098377e-07 6.238328276289432 0.1328672735648493 T(ph)QTPPVEENVTQK ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVEENVTQK 13 0 Q6P1Q9-2;Q6P1Q9 Q6P1Q9-2 METTL2B Methyltransferase-like protein 2B 1 T(0.978)QT(0.022)PPVEENVTQK 169.98 0.00056045 16250000.0 60164.0 52168.0 53051.0 55021.0 54869.0 42427.0 47618.0 48885.0 33718.0 47783.0 True False 56820.325735574435 56169.11785344158 49637.75641756148 47527.04488348092 47975.8656849163 48270.934136040276 49832.33135327693 49027.247256652576 40462.542159635705 46403.380634856294 1.224486771399008 1.2104531412362156 1.0697012962946855 1.0242151376311703 1.0338872950320956 1.040246065601978 1.073894416128918 1.0565447298429231 0.8719740158164666 1.0 15.501942293684133 -5.328093021548661 2.444381004821026 1.0210522463435363 1.2291341742897648 0.7003196209094902 0.05230603826572585 0.17012107810302415 1.9354524357939367 0.014616482840214507 0.04400294802137021 4.697934727493815e-06 5.328093021548661 0.20808192794622848 T(ph)QTPPVS(ph)PAPQPTEER ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.876)QT(0.124)PPVS(0.753)PAPQPT(0.247)EER 157.7 0.012683 159090000.0 39878.0 28415.0 32880.0 32943.0 30012.0 29503.0 42645.0 34614.0 29501.0 33569.0 True False 37661.74040428227 30594.33913137445 30764.536597037208 28456.106570155258 26241.624249315813 33566.77044843135 44628.07699946442 34714.721009343826 35402.02432681098 32599.775747263484 1.1552760576104177 0.9384831162202895 0.9437039332891628 0.8728927091636188 0.8049633363357909 1.0296626181929807 1.3689688341862483 1.0648760678133768 1.0859591366907706 1.0 14.992574419790353 -7.00368790241994 24.984412572864013 1.1444942641635305 0.9367831434883321 0.3375723951471534 0.12258924635452577 162.6874227935483 1102163.5746461572 0.04417168676137677 0.038131882989129784 9.915442435867964e-08 7.00368790241994 -0.20771112067519837 T(ph)QTPPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R1 1 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 T(0.674)QT(0.326)PPVSPAPQPTEER 178.02 2.6502e-06 127570000.0 3015.7 4056.0 2335.0 2257.9 2223.8 2374.5 2796.4 2469.6 1292.2 2569.2 True False 3085.959942469285 3581.1216344167583 2017.919825236901 1863.6001510322797 2022.6576826437774 2350.614685873499 2585.4652966054455 2404.0981856086487 2192.769021446121 2898.9818461272466 1.0644978500268372 1.2353032286838164 0.6960788070931325 0.6428464371109689 0.6977131248151306 0.810841464569255 0.8918528758844667 0.8292905279211342 0.7563928088668246 1.0 11.501330583710173 -5.261553137729065 24.99999999610816 0.7802711590517444 1.1499005584845843 0.647396052344105 0.1058375506686861 5.735399814591644 1260784.7217046658 0.028161490138701947 0.06536327218010714 5.475790982917529e-06 5.261553137729065 0.3696293994328399 T(ph)QTPPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R2 2 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 T(0.896)QT(0.073)PPVS(0.026)PAPQPT(0.005)EER;T(0.836)QT(0.164)PPVSPAPQPTEER 185.59 1.8033e-06 107852000.0 54402.0 37925.0 45339.0 53640.0 50805.0 44717.0 49079.0 49319.0 39268.0 41704.0 True False 51378.554628460886 40833.72555190483 42421.93810137076 46334.139465838794 44422.421697537284 50876.36084949005 51361.270748193536 49462.510124800036 47122.69723959232 40499.8971599951 1.2686095084510853 1.0082426972737966 1.0474579215295938 1.1440557313712547 1.0968527036512272 1.2562096305702375 1.268182744891685 1.221299647487945 1.1635263431270901 1.0 15.305630624165145 -6.742723049910442 24.726026500157726 1.2010710946714633 1.1053006374999994 0.09638382952761171 0.09528996057447058 356.13578781262686 470487.3052406664 0.030492991549061568 0.030439996663573887 1.808326930558539e-07 6.742723049910442 -0.09577045717146393 T(ph)QVLSPDSLFTAK ddPTM_A459_Selumetinib_30min_R2 1 TQVLSPDSLFTAK 13 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-1;H0Y8L4;H0Y948 A8MQ02 MLLT4 Afadin 1 T(0.724)QVLS(0.179)PDS(0.08)LFT(0.017)AK 134.88 0.0028704 0.0 29181.0 24116.0 28945.0 25572.0 32404.0 21632.0 27017.0 21358.0 19463.0 30372.0 True False 27559.23684079844 25965.619654838138 27082.71021293315 22089.04948583948 28333.1198245645 24611.611644255387 28273.34403316988 21420.148243992757 23356.143841656976 29495.081444067033 0.934367206039433 0.8803372760328875 0.9182110673025745 0.7489062041658717 0.9606049021527193 0.8344310454245597 0.9585782662368981 0.7262278046125362 0.791865717880738 1.0 14.848186772400974 -7.750224396360746 24.999496535308783 0.8192850414045993 0.8864922292140246 0.05140674777545018 0.08816730675481034 463.6188566600805 1033465.9121806452 0.03956275402692054 0.0225739670254705 1.7773608251335284e-08 7.750224396360746 0.06720718780942525 T(ph)RHSPTPQQSNR ddPTM_A459_Selumetinib_30min_R2 2 TRHSPTPQQSNR 12 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.992)RHS(0.008)PTPQQSNR;T(1)RHSPTPQQSNR 86.911 0.040478 400860000.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3356.6000000000004 0.0 1245.04 True False 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3366.3671502849547 0.0 1209.09246019759 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7842098607866785 0.0 1.0 10.239708857427887 -7.618697512874641 24.971370996652542 1.313747292283544 5.847972962529062e-06 0.45535977322851773 0.631399841482645 11.713148407585178 3044.7740415134817 0.2672278541164793 0.1542839468545587 2.4060380276692673e-08 7.618697512874641 -1.3137414443105815 T(ph)RNSGIWESPELDR ddPTM_A459_Selumetinib_30min_R1 1 TRNSGIWESPELDR 14 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 T(0.966)RNS(0.034)GIWESPELDR 100.07 0.012803 11386000.0 732.67 959.26 732.33 929.25 813.43 696.74 896.62 955.9 464.23 393.72 True False 749.7397854723515 846.9493932521248 632.883608400745 766.9739316828673 739.8554001227309 689.7314281893043 828.9872315270964 930.5464267992018 787.7644039823041 444.2577971575662 1.6876232454878877 1.9064367551251662 1.424586383064152 1.7264163658805574 1.6653740347528987 1.5525477157684535 1.8660049116325967 2.094609104787782 1.7732145817643477 1.0 8.79525328695572 -7.267963415570418 24.729146681592685 1.7746745648625177 1.6641712292007174 0.0 0.2904825922634759 2040.5219337920767 7734494.032125533 0.11395648958248508 0.07896264153400694 5.395560721364403e-08 7.267963415570418 -0.11050333566180037 T(ph)RNSGIWESPELDR ddPTM_A459_Selumetinib_30min_R2 1 TRNSGIWESPELDR 14 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 T(0.506)RNS(0.213)GIWES(0.281)PELDR 152.94 0.0038642 7652700.0 17458.0 16132.0 15000.0 14474.0 14935.0 14117.0 13909.0 13974.0 12244.0 13976.0 True False 16487.75424991122 17369.272527444395 14034.916330765143 12502.616230957328 13058.731779405958 16061.488608633212 14555.796060160628 14014.662026479766 14693.142125943998 13572.476565991074 1.2147933481222608 1.279742311065547 1.0340718779307247 0.9211742728136644 0.9621480439411906 1.183386726110025 1.072449526023385 1.0325795707466305 1.0825689810186157 1.0 13.728396372485893 -5.266401335913852 24.738171040423737 1.037031247795509 1.2472678382761846 0.6014952284907941 0.06876588911621065 232.32714400906272 1158289.0454642836 0.019494439856583636 0.042742257404984545 5.4150025326619166e-06 5.266401335913852 0.21023659048067556 T(ph)RSEITFGQVK ddPTM_A459_Selumetinib_30min_R1 1 TRSEITFGQVK 11 1 F5H5A3;Q8IVH8-3;Q8IVH8-2;Q8IVH8;H7C1A4 F5H5A3 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase;Mitogen-activated protein kinase kinase kinase kinase 3 1 T(0.635)RS(0.362)EIT(0.003)FGQVK 128.54 0.028567 25111000.0 1469.0 1646.4 1481.9 1592.2 1756.6 1248.9 1455.6 1205.2 926.9 1153.5 True False 1503.2248418235838 1453.6387226094046 1280.6661194940305 1314.1521592956267 1597.7158401529182 1236.3371999104716 1345.8029200897165 1173.2341809586753 1572.8816019024994 1301.5629610414828 1.154938244878093 1.1168408798651077 0.9839448093000963 1.009672369782304 1.2275363451295973 0.9498865878306655 1.0339898724628993 0.9014040934446064 1.2084560247810934 1.0 10.346029386173852 T(ph)RSEPLPPSATAPPPPGPMQPR ddPTM_A459_Selumetinib_30min_R2 3 TRSEPLPPSATAPPPPGPMQPR 22 1 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.5)RS(0.5)EPLPPSATAPPPPGPMQPR;T(0.835)RS(0.165)EPLPPSATAPPPPGPMQPR;T(0.775)RS(0.225)EPLPPSATAPPPPGPMQPR 118.46 4.5839e-05 33592600.0 51631.0 45109.4 42517.5 35297.2 34102.2 29052.5 41110.8 45653.9 28653.300000000003 34564.0 True False 48761.55571526899 48569.1459304178 39781.97033955384 30489.660468933725 29817.976758463872 33054.21816266319 43022.53365950479 45786.74529058999 34384.760640094 33566.047511942976 1.4527047218746671 1.4469724477729062 1.1851848307549229 0.9083482485712786 0.8883374412150993 0.9847515752607549 1.2817277233548916 1.3640791420049927 1.024391109136687 1.0 15.034715045550291 -5.352447217391894 3.6258560129062203 1.076550625757782 1.454460761769487 0.5248088515865965 0.14403058011520586 0.20962681267829894 5.107818613853588 0.04438395912521754 0.10506814358711047 4.44173641371296e-06 5.352447217391894 0.377910136011705 T(ph)RSNPEGAEDR ddPTM_A459_Selumetinib_30min_R1 1 TRSNPEGAEDR 11 1 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9;M0R2I2 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 T(0.82)RS(0.18)NPEGAEDR 102.95 0.01906 18773000.0 1371.8 1527.0 1854.2 2290.0 2114.1 1504.0 1909.7 1470.5 1058.3 1197.0 True False 1403.760270941859 1348.2181301169594 1602.4098243915469 1890.0944886239079 1922.880028274671 1488.8711255227397 1765.6497914917093 1431.4975631428251 1795.8578048262113 1350.6466097673651 1.039324617402062 0.9982019873793456 1.1864019890943533 1.3993997208118392 1.4236736792356568 1.1023395126125421 1.3072625946144596 1.0598609234945517 1.329628188335311 1.0 10.399434534434372 -5.357866077825247 4.458562946868134 1.2430534727256537 1.0192052475669822 0.27352078357246534 0.1352051828909235 0.2590439418565115 8.67804366036656 0.03550164382417662 0.07873028067737484 4.386659471119372e-06 5.357866077825247 -0.22384822515867153 T(ph)RSNPEGAEDR ddPTM_A459_Selumetinib_30min_R2 1 TRSNPEGAEDR 11 1 M0QXG9;M0R3F4;M0R2A4;M0R2K3;M0R193;M0R0I0;J3KQS6;Q9NWV8-3;Q9NWV8;M0R3H9;M0R2I2 M0QXG9 BABAM1 BRISC and BRCA1-A complex member 1 1 T(0.761)RS(0.239)NPEGAEDR 123.28 0.040514 66096000.0 42066.0 38302.0 37541.0 35081.0 39067.0 28896.0 31762.0 37675.0 27944.0 35726.0 True False 39728.140123540215 41239.64023965878 35125.65293155031 30302.907281899534 34159.05419658873 32876.16170822873 33238.99593520901 37784.628012568 33533.58082059611 34694.497552704415 1.1450847519318934 1.1886507414327485 1.0124271976612695 0.8734211307100321 0.9845669084758385 0.9475900799049344 0.9580480560272028 1.0890668745143048 0.9665388803989808 1.0 15.082419253220628 -5.339210972546612 4.686614550360696 0.9746584587243597 1.166884057184698 0.6831674274756872 0.05155100301530776 0.11612625725878688 4.637544894203721 0.014179587228847323 0.031421770150639475 4.579193835705874e-06 5.339210972546612 0.19222559846033815 T(ph)RSPDVISSASTALSQDIPEIASEALSR ddPTM_A459_Selumetinib_30min_R2 1 TRSPDVISSASTALSQDIPEIASEALSR 28 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 T(0.756)RS(0.242)PDVIS(0.001)S(0.001)ASTALSQDIPEIASEALSR 90.955 1.8602e-05 285630000.0 15778.0 20158.0 18670.0 20599.0 22692.0 16571.0 11852.0 17648.0 11213.0 18685.0 True False 14901.121924338366 21704.05378181405 17468.79252635902 17793.380664742974 19841.228090946097 18853.50483343917 12403.141484292459 17699.35275821632 13455.913317397099 18145.515500539717 0.8212013554475842 1.196111170342253 0.9627057729960568 0.9805938367644463 1.093450780737309 1.03901731713703 0.6835375651864805 0.9754119555153928 0.7415558580849835 1.0 14.14732542283724 -7.217872243709159 24.99373631506175 0.8480772324363435 1.0232774217914122 0.29091921295830314 0.1261284600530606 529.4441470484529 303733.6161742819 0.04466858929536059 0.03459992475258203 6.05518973910504e-08 7.217872243709159 0.17520018935506876 T(ph)RSYDNLTTACDNTVPLASR ddPTM_A459_Selumetinib_30min_R1 1 TRSYDNLTTACDNTVPLASR 20 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 T(0.661)RS(0.222)Y(0.115)DNLT(0.002)TACDNTVPLASR 69.771 0.016252000000000003 21536000.0 1183.6 1209.8 1224.7 1383.2 1430.9 1277.7 1139.1 880.71 479.19 912.5 True False 1211.1755771153123 1068.1560535792385 1058.3924667955594 1141.650085879733 1301.4753476459132 1264.8474980587794 1053.176769905329 857.3507098507431 813.1504313471345 1029.6282635026894 1.1763231644351113 1.0374191263412695 1.02793649350205 1.1087983171673599 1.264024496781419 1.2284506388314345 1.0228708818875367 0.832679851788571 0.7897514667875184 1.0 10.00790784614561 -7.5840446572951326 4.018676467052599 0.860782908585935 1.134816612383072 0.6537832235902072 0.08645514343401207 0.14261302404179707 4.687021546418156 0.04697253942186261 0.02622144385647268 2.6058855802466013e-08 7.5840446572951326 0.2740337037971371 T(ph)RSYDNLTTACDNTVPLASR ddPTM_A459_Selumetinib_30min_R2 2 TRSYDNLTTACDNTVPLASR 20 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 T(0.5)RS(0.284)Y(0.216)DNLTTACDNTVPLASR;T(0.448)RS(0.448)Y(0.104)DNLTTACDNTVPLASR 116.98 0.00036635 29305200.0 24788.0 21869.6 35952.1 32310.3 31245.4 20119.1 19433.4 15833.4 14603.6 30338.9 True False 23410.382194226087 23546.927998152605 33638.98102768677 27909.58140162364 27320.073514579894 22890.32340199421 20337.09160655157 15879.472572639523 17524.728058676556 29462.937127071167 0.7945705512406682 0.7992050451927684 1.141738886473018 0.9472776349911065 0.9272691787906521 0.7769192631158995 0.6902601569843294 0.5389643437160625 0.5948058736674446 1.0 14.846613637738665 -6.95912077404952 2.516686229175814 0.6683177612708857 0.9302089870772571 0.31822731345231126 0.14609696383557322 0.301831388396969 3.869134322570039 0.05997760599138707 0.04912683739617189 1.0987002566146129e-07 6.95912077404952 0.26189122580637136 T(ph)RT(ph)T(ph)RRR ddPTM_A459_Selumetinib_30min_R2 2 TRTTRRR 7 3 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 3 T(1)RT(1)T(1)RRR;T(1)RT(1)T(1)RRR 84.615 0.017503 15871000.0 1324.3 10572.900000000001 1224.6 3496.9 3251.6 2609.9 2928.0 1392.2 0.0 1018.6 True False 1250.7007075929332 11383.80743276821 1145.810569243667 3020.6161875110315 2843.1049383271775 2969.390034686675 3064.1578017219317 1396.251071508882 0.0 989.190371359367 1.2643680567514957 11.508206875410982 1.1583317048153927 3.053624736925042 2.8741736885490714 3.0018387973248006 3.097642163167338 1.41150895918055 0.0 1.0 9.950104386579305 -6.048762812246868 0.4063210485128373 0.7006693916725847 6.678702844438511 0.2101352108408161 2.7259876692504075 3.089631627834236 0.8209067620789501 2.517385707485622 8.170500992120912 8.937934912922645e-07 6.048762812246868 5.978033452765926 T(ph)RTPASINATPANINLADLTR ddPTM_A459_Selumetinib_30min_R1 2 TRTPASINATPANINLADLTR 21 1 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 T(0.491)RT(0.491)PAS(0.018)INATPANINLADLTR;T(0.484)RT(0.484)PAS(0.032)INATPANINLADLTR 111.4 0.00014115 63065000.0 3454.3 2914.9 3546.7 3478.0 3387.3 2704.2 2873.0 2708.8 1635.46 2543.2 True False 3534.7784691022507 2573.6221528997557 3065.077620628571 2870.632590145828 3080.9193130763874 2676.9982032171483 2656.287296934431 2636.953824577549 2775.256170727652 2869.644492865797 1.2317827096318164 0.8968435495400283 1.0681036024666606 1.0003443274184267 1.0736240397498154 0.9328675415621742 0.9256503039098426 0.9189130678497845 0.9671080085450294 1.0 11.486656303741482 -6.768759297550124 24.98561258325817 0.9423862412771284 1.0431881221627182 0.29179667709843726 0.08075863733499547 219.95101317739233 750770.104252244 0.02647512158050667 0.023805498514883425 1.7031021705885422e-07 6.768759297550124 0.10080188088558972 T(ph)RTPASINATPANINLADLTR ddPTM_A459_Selumetinib_30min_R2 2 TRTPASINATPANINLADLTR 21 1 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 T(0.499)RT(0.499)PAS(0.003)INATPANINLADLTR;T(0.498)RT(0.498)PAS(0.005)INATPANINLADLTR 113.63 0.00011799 21159200.0 46680.0 47294.0 49261.0 53745.0 55007.0 43727.0 40844.0 45802.0 41185.0 56191.0 True False 44085.71247484567 50921.297725821656 46091.60089132149 46424.83828470373 48096.52889118068 49749.99733581528 42743.326930850584 45935.27623707069 49423.15080504763 54568.619828248746 0.8078949515967719 0.9331608145137846 0.8446539611298923 0.8507607198207129 0.8813953704997751 0.9116960900312345 0.7832949974799158 0.8417892257793773 0.9057064474161863 1.0 15.735783934491055 -8.602801703167717 3.6950342854244718 0.9999177378837073 0.8593207855811914 0.5187246195617832 0.042113870781999414 0.28899753023511454 9.968664763509722 0.04025984832847683 0.010584166700142636 2.4957340073207817e-09 8.602801703167717 -0.1405969523025159 T(ph)S(ph)ALPGET(ph)QRRL ddPTM_A459_Selumetinib_30min_R1 2 TSALPGETQRRL 12 2 J3QLL8;Q8N584-3 J3QLL8 TTC39C 3 T(1)S(1)ALPGET(1)QRRL;T(1)S(1)ALPGET(1)QRRL 116.37 0.019141 17541800.0 468.3 250.48 438.79999999999995 516.6 572.95 401.444 599.6700000000001 515.0899999999999 241.65 463.71 True False 479.2104788468237 221.15368515500717 379.21337015586784 426.3855077830176 521.1267736625382 397.40583784198833 554.436409102913 501.4281399518784 410.06240058230554 523.2316954178988 0.9158666859126035 0.42266874711856744 0.7247522913400626 0.814907643242959 0.9959770752158288 0.7595217211078643 1.0596384239683556 0.9583290621402318 0.7837109337476081 1.0 9.031306126324049 -5.851335648597975 2.7142693821341446 0.9217288816653022 0.6540683029187951 0.3561992210633187 0.14252541507849556 0.26422995028521834 3.9417974873239343 0.04041498219790397 0.067497605789005 1.4082000370286693e-06 5.851335648597975 -0.26766057874650706 T(ph)S(ph)S(ph)AVS(ph)T(ph)PSKVK ddPTM_A459_Selumetinib_30min_R1 1 TSSAVSTPSKVK 12 1 Q9P2N5;U3KPZ7 Q9P2N5 RBM27 RNA-binding protein 27 5 T(0.999)S(1)S(1)AVS(0.982)T(0.902)PS(0.117)KVK 66.98899999999999 0.025523 4293200.0 975.36 628.52 617.04 729.72 1556.9 547.23 1120.6 992.36 149.69 280.63 True False 998.0839902798167 554.9325862089793 533.2493571581056 602.2881005408897 1416.07866989302 541.7253630450859 1036.0722397997642 966.0393891604303 254.01299707496506 316.6515940676819 3.151994207445814 1.7525021083278254 1.6840254941022892 1.902052956070561 4.472040237354194 1.7107931025583158 3.2719628108940184 3.0507959134225824 0.8021844886739199 1.0 8.306752531924518 T(ph)S(ph)S(ph)PSVEDATPALGVRT(ph)RS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 TSSPSVEDATPALGVRTRSR 20 2 K7ER94;Q2V2M9-2;Q2V2M9;Q2V2M9-3;Q2V2M9-4;A0A0A0MTS9;K7EP24 K7ER94 FHOD3 FH1/FH2 domain-containing protein 3 5 T(0.761)S(0.761)S(0.863)PS(0.321)VEDAT(0.347)PALGVRT(0.992)RS(0.955)R 40.349 0.04763 173400.0 0.0 0.0 0.0 505.22 0.0 0.0 0.0 0.0 527.55 0.0 True False 0.0 0.0 0.0 436.408164446888 0.0 0.0 0.0 0.0 633.0747409785815 0.0 0.0 T(ph)S(ph)VS(ph)QT(ph)S(ph)LLEAK ddPTM_A459_Selumetinib_30min_R2 1 TSVSQTSLLEAK 12 0 P51587 P51587 BRCA2 Breast cancer type 2 susceptibility protein 5 T(1)S(1)VS(1)QT(1)S(1)LLEAK 58.246 0.046713 0.0 1307.8 5261.9 7488.4 11598.0 10187.0 9084.6 3913.9 7270.8 12073.0 8751.7 True False 1235.1177115382002 5665.4708103247995 7006.604496753446 10018.332392334047 8907.217987064512 10335.921188212027 4095.904105245719 7291.956824254262 14487.93734780479 8499.015681352606 0.14532479499339304 0.6666031717949658 0.8244018789289203 1.178763843713681 1.0480293625775428 1.2161315587274077 0.4819268793952692 0.8579766290175567 1.7046606208283939 1.0 13.053080048987567 -4.91983756108255 1.5388963700794238 1.0400100452971912 9.325270122821669e-12 0.47935975238414197 0.29414119312874726 0.7778551870445539 2.142264728914912 0.0860263866605659 1.1419260168098389 1.202714201006101e-05 4.91983756108255 -1.040010045287866 T(ph)SAPATPEIQGR ddPTM_A459_Selumetinib_30min_R1 2 TSAPATPEIQGR 12 0 Q3KP66-3;Q3KP66 Q3KP66-3 C1orf106 Uncharacterized protein C1orf106 1 T(0.835)S(0.165)APATPEIQGR;T(0.983)S(0.017)APATPEIQGR 161.25 0.0011235 59418000.0 6679.799999999999 7168.200000000001 7700.3 7863.2 6889.0 6369.799999999999 6671.9 6308.700000000001 3702.2999999999997 5289.299999999999 True False 6835.426343371793 6328.9438115942285 6654.641554720218 6490.039730544761 6265.891166351733 6305.725595315652 6168.633211422496 6141.372782454365 6282.532694706682 5968.23317714496 1.145301488813759 1.0604384285504447 1.1150103149796196 1.0874306579370983 1.0498737198048225 1.0565481287599656 1.0335777822899008 1.0290101945031964 1.0526620707055006 1.0 12.543088187034561 -1.5228787452803376 0.15562009213614872 0.9913283655643864 1.49677092910848 0.7366364034202297 0.02077803135850131 33.73525935590252 0.34227828491523116 0.06551796999205248 3.880864823163042 0.029999999999999995 1.5228787452803376 0.5054425635440937 T(ph)SAPATPEIQGR ddPTM_A459_Selumetinib_30min_R2 2 TSAPATPEIQGR 12 0 Q3KP66-3;Q3KP66 Q3KP66-3 C1orf106 Uncharacterized protein C1orf106 1 T(0.631)S(0.368)APATPEIQGR;T(0.91)S(0.09)APATPEIQGR 158.86 0.001071 30360900.0 159520.0 150781.0 166156.0 174988.0 166333.0 118035.0 118688.0 137659.0 104999.0 150865.0 True False 150654.51700915565 162345.41786267 155465.70385697435 151154.33252886301 145436.76150411315 134293.24983495218 124207.22717581037 138059.5648993258 126001.73391718346 146509.13545565592 1.0282943554380226 1.1080907505034543 1.0611331735284815 1.0317058527358047 0.9926804977163534 0.9166203146123871 0.8477780364310751 0.9423273468234508 0.8600264654166944 1.0 17.160631099942073 -6.476395601553502 1.7494370186675838 0.9040367754842653 1.066840805663647 0.7008733584424724 0.04438391267388453 0.1797359758987216 1.1057929559237278 0.016007383487072323 0.018089955826712384 3.338907582859321e-07 6.476395601553502 0.1628040301793816 T(ph)SDANETEDHLESLICK ddPTM_A459_Selumetinib_30min_R2 1 TSDANETEDHLESLICK 17 0 F2Z2T1;Q09161 F2Z2T1 NCBP1 Nuclear cap-binding protein subunit 1 1 T(0.485)S(0.485)DANET(0.029)EDHLESLICK 111.57 0.0030073 0.0 21074.0 18339.0 23247.0 26347.0 21836.0 13886.0 24855.0 27751.0 22598.0 35962.0 True False 19902.791445906132 19745.542330820896 21751.31332941982 22758.493148889902 19092.766463683187 15798.670455442416 26010.806749248146 27831.750815574618 27118.231440875734 34923.68361950279 0.5698938194134714 0.5653911696701487 0.6228241432491104 0.6516635930174514 0.5466996744015004 0.45237697797204307 0.7447898976705499 0.7969305620450715 0.776499745454452 1.0 15.091918116618492 -8.129795093438704 0.9033134267606225 0.9762616281755037 0.5741146868308258 0.7832236931303662 0.07029714912606573 0.2603277495322718 0.4250460362086631 0.07011968711853503 0.026188653768050848 7.4166008496355265e-09 8.129795093438704 -0.4021469413446779 T(ph)SDFNTFLAQEGCTK ddPTM_A459_Selumetinib_30min_R1 2 TSDFNTFLAQEGCTK 15 0 Q9UHD1;E9PHZ2;Q9UHD1-2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 T(0.999)S(0.001)DFNTFLAQEGCTK;T(0.995)S(0.005)DFNTFLAQEGCTK 214.34 8.0296e-07 7395700.0 3722.9300000000003 2711.84 3307.3100000000004 3200.3999999999996 3004.76 3043.86 2988.82 2484.95 1897.8400000000001 2384.44 True False 3809.667025439259 2394.3365120997887 2858.195467753426 2641.5102189484496 2732.9799885334664 3013.2415320037558 2763.370901087213 2419.0410537448224 3220.495867250664 2690.5061004124423 1.4159666929784156 0.8899204918110938 1.0623263286098024 0.9817893438500356 1.0157865793779517 1.1199534286660193 1.0270821912143595 0.8991026087523066 1.196985157088838 1.0 11.393661862603185 -4.749399499421048 24.99489489367935 1.0214024691669654 1.4159675887407768 0.646637635966457 0.08749412539676987 332.66191336891296 690566.6952348471 0.0204822022441824 0.3355623174346033 1.780739944228616e-05 4.749399499421048 0.39456511957381135 T(ph)SDFNTFLAQEGCTK ddPTM_A459_Selumetinib_30min_R2 1 TSDFNTFLAQEGCTK 15 0 Q9UHD1;E9PHZ2;Q9UHD1-2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 T(0.924)S(0.075)DFNTFLAQEGCTK 98.552 0.020598 2131900.0 10507.0 8363.3 10961.0 11891.0 9626.5 9782.5 11255.0 9093.2 7810.4 11760.0 True False 9923.063002853547 9004.738217752025 10255.78119343445 10271.425286880862 8417.133007998087 11129.9505783066 11778.3798013594 9119.659706539704 9372.698240809616 11420.45824385053 0.8688848372784629 0.7884743348718712 0.8980183609494643 0.8993881915738033 0.7370223530680465 0.9745625211054594 1.0313403849360947 0.7985371087408234 0.8206937095415106 1.0 13.47933291929286 -6.788277165028107 24.997419384760075 0.9190798872871698 0.8422912633151822 0.21536618423422826 0.08215220466617765 428.21721687524587 398849.7818910103 0.0303801766174306 0.026799601104089854 1.6282565540586804e-07 6.788277165028107 -0.0767886239719876 T(ph)SDSDQQAYLVQR ddPTM_A459_Selumetinib_30min_R1 3 TSDSDQQAYLVQR 13 0 Q96CV9-3;Q96CV9-2;Q96CV9 Q96CV9-3 OPTN Optineurin 1 T(0.988)S(0.012)DSDQQAYLVQR;T(0.92)S(0.08)DSDQQAYLVQR;T(0.863)S(0.137)DS(0.001)DQQAYLVQR 266.07 1.8947e-30 67502000.0 7448.5 8480.7 8593.4 9372.2 8262.3 8623.4 9127.699999999999 8382.8 5247.9 6788.799999999999 True False 7622.035557741973 7487.775701429537 7426.463480167357 7735.521207982957 7514.976423827538 8536.65642542074 8439.190240246568 8160.460912828066 8905.303008549066 7660.208608511849 0.9950167087189429 0.9774897896526331 0.9694858011980563 1.0098316642953329 0.9810407010948851 1.1144156591159937 1.1016919605647726 1.0653053108449746 1.1625405342948099 1.0 12.903167965894243 -6.756427677431095 24.999934044752752 1.0936786092785675 0.9864111642605017 0.6215122412702359 0.039792475263683985 75.09243430445662 374584.3482322757 0.012460764498630834 0.012087841864033166 1.7521541941710156e-07 6.756427677431095 -0.10726744501806584 T(ph)SDSDQQAYLVQR ddPTM_A459_Selumetinib_30min_R2 2 TSDSDQQAYLVQR 13 0 Q96CV9-3;Q96CV9-2;Q96CV9 Q96CV9-3 OPTN Optineurin 1 T(0.989)S(0.011)DSDQQAYLVQR;T(0.992)S(0.007)DS(0.001)DQQAYLVQR 247.17 2.3396e-22 73280000.0 119870.0 98623.0 95984.0 105804.0 84536.0 74389.0 76108.0 95180.0 77580.0 120986.0 True False 113208.10527762961 106187.0669770735 89808.49393947737 91393.31267791949 73915.8319185712 84635.40951389208 79647.17280514103 95456.9580421027 93098.16776631276 117492.81982062048 0.9635321158388023 0.9037749467515735 0.7643743173122448 0.7778629606256124 0.6291093535027973 0.720345376365188 0.6778897036154257 0.8124492899892901 0.7923732523268086 1.0 16.84221306845518 -5.161329942827803 2.4588948053413717 0.752961156171154 0.9624461126151045 0.31479544578371 0.0942967946973472 0.33154492890681536 3.6688863798678657 0.02467373088281627 0.10105480633649776 6.897156130094231e-06 5.161329942827803 0.2094849564439505 T(ph)SDTETEPSK ddPTM_A459_Selumetinib_30min_R1 1 TSDTETEPSK 10 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 T(0.876)S(0.124)DTETEPSK 194.48 0.00039863 10571000.0 3996.0 13504.0 4206.0 5583.5 4083.5 5565.7 5748.0 4985.2 2479.1 5533.3 True False 4089.099025137532 11922.945402160723 3634.848301904241 4608.4465402758 3714.1481460004825 5509.714111251272 5314.423732258649 4852.976301788245 4206.851633699953 6243.552953906233 0.654931423714316 1.909641111428585 0.5821762590529684 0.738112830034149 0.5948773356165343 0.882464544134948 0.8511858186345195 0.7772779918126611 0.6737912955583996 1.0 12.608151526931204 -5.306635778906337 24.999409532160637 0.7551276942088683 1.282289282052885 0.31583247470351195 0.3058662028944824 396.0482969061224 219064.79682082 0.07298704206036466 0.1519355393725405 4.9358757767704585e-06 5.306635778906337 0.5271615878440168 T(ph)SDTETEPSK ddPTM_A459_Selumetinib_30min_R2 1 TSDTETEPSK 10 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 T(0.988)S(0.012)DTETEPSK 130.01 0.006670100000000001 3905600.0 52773.0 41524.0 46961.0 46580.0 36950.0 30029.0 66679.0 76694.0 38660.0 64191.0 True False 49840.08792705724 44708.75727929586 43939.58038727083 40235.7236450181 32308.010662808854 34165.22217387877 69779.70562193192 76917.16684262473 46393.08025065297 62337.63904175246 0.7995183759474013 0.7172032493779699 0.7048643654572962 0.6454483080129013 0.5182745313977903 0.5480673105215873 1.1193831960045024 1.2338800125411744 0.7442226071407653 1.0 15.927815895320297 -7.2641459165549485 24.999879772484555 1.0438614687474668 0.6539053995667012 0.6297897129776517 0.13820037028692786 156.1457871697295 1442283.646746658 0.05744163961801481 0.040696007037000846 5.443197386937854e-08 7.2641459165549485 -0.38995606918076553 T(ph)SDVGGYYYEK ddPTM_A459_Selumetinib_30min_R1 4 TSDVGGYYYEK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.918)S(0.082)DVGGYYYEK;T(0.909)S(0.091)DVGGYYYEK;T(0.991)S(0.009)DVGGYYYEK;T(0.991)S(0.009)DVGGYYYEK 244.73 1.0151e-10 209858000.0 15038.5 19446.9 15447.1 15989.099999999999 15276.699999999999 14419.6 16733.600000000002 14997.5 9122.2 13538.8 True False 15388.867790172884 17170.04790738146 13349.468664846647 13196.903837579259 13894.925182320445 14274.55191594927 15471.37107970136 14599.717581254337 15479.707140872786 15276.63685907969 1.0073465732103521 1.1239416152761672 0.8738486610626194 0.8638618538435481 0.9095539358888391 0.9344040869483109 1.012747191834041 0.9556892473081845 1.013292865678901 1.0 13.899039349574348 -10.013439613987988 14.075373382538556 0.9999999999997571 0.9634736672151353 0.017618359020697416 0.07372432244979715 0.0 0.0 0.07726937327426547 0.018740575743239705 9.695280669223652e-11 10.013439613987988 -0.03652633278462181 T(ph)SDVGGYYYEK ddPTM_A459_Selumetinib_30min_R2 3 TSDVGGYYYEK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.861)S(0.139)DVGGYYYEK;T(0.989)S(0.011)DVGGYYYEK;T(0.999)S(0.001)DVGGYYYEK 226.42 1.2425e-06 108899000.0 471388.0 436329.0 451463.0 501968.0 504622.0 452547.0 512033.0 521657.0 382079.0 486627.0 True False 445190.1420756755 469794.0312811354 422416.36209574906 433599.0924569017 441226.87298208184 514881.2414373545 535843.5490741417 523174.9355050349 458505.47617923416 472576.8141012124 0.942048210558905 0.9941114698456598 0.8938575687407287 0.9175208760115708 0.9336617028519382 1.0895186265466712 1.1338760876224014 1.1070685651390968 0.9702242312739351 1.0 18.850189322957704 -6.757394219010688 24.985076710230967 1.0714379574888095 0.9360605009957987 0.5885800561010854 0.05136039646366911 69.45453098706814 428989.00647740386 0.017662430033041087 0.01704956850816452 1.7482590335428508e-07 6.757394219010688 -0.1353774564930108 T(ph)SFSFQK ddPTM_A459_Selumetinib_30min_R2 2 TSFSFQK 7 0 H0Y7F8;Q9BPZ7-4;Q9BPZ7-3;Q9BPZ7-2;Q9BPZ7 H0Y7F8 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1 1 T(0.95)S(0.05)FSFQK;T(0.993)S(0.007)FSFQK 114.89 0.031427 23923000.0 198088.0 156692.0 188486.0 190085.0 183728.0 136419.0 186426.0 174396.0 150215.0 156034.0 True False 187079.06196909244 168709.77255580944 176359.01596803963 164195.0950850853 160646.44609084007 155209.47896161614 195095.17839611115 174903.4634871878 180262.19735778158 151528.89299498074 1.2346098375792218 1.113383521922765 1.163863950183292 1.0835893527614178 1.0601703933530442 1.024289664458628 1.2875114081548362 1.1542581749936056 1.189622611205591 1.0 17.209233382367806 -11.969629260949027 1.8989084289906482 4.0985236583926496e-05 1.141793052425388 0.24823829915391016 0.07579120997772107 1605425.66175986 92444.4978508085 6930682.545607348 0.021338309404731384 1.0724344070285187e-12 11.969629260949027 1.1417520671888042 T(ph)SGETTQTHTEPTGDSK ddPTM_A459_Selumetinib_30min_R1 2 TSGETTQTHTEPTGDSK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 T(0.836)S(0.15)GET(0.007)T(0.007)QTHTEPTGDSK;T(0.807)S(0.193)GETTQTHTEPTGDSK 135.98 0.0006984 15841900.0 5540.6 16036.1 7200.9 10063.0 7350.4 8035.400000000001 10059.6 6905.9 3570.4 7491.9 True False 5669.685199869129 14158.585957019359 6223.057331712372 8305.685955904968 6685.55761781852 7954.571171559451 9300.796272969577 6722.733098475372 6058.708028301527 8453.558342285816 0.670686232980568 1.6748670067368248 0.7361464935521668 0.9825076754198087 0.7908572162300551 0.9409731203686895 1.1002226395535435 0.795254829536974 0.7167050587437326 1.0 13.045343025131283 T(ph)SGETTQTHTEPTGDSK ddPTM_A459_Selumetinib_30min_R2 1 TSGETTQTHTEPTGDSK 17 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 T(0.79)S(0.186)GET(0.011)T(0.011)QT(0.001)HTEPTGDSK 95.227 0.0087837 10507000.0 26330.0 28155.0 31797.0 20077.0 18644.0 17860.0 23702.0 22705.0 18288.0 30367.0 True False 24866.68400734119 30314.39796740622 29751.21563795596 17342.4779652432 16301.774040525259 20320.052883062188 24804.189964621997 22771.067790984907 21946.111009413886 29490.225807058592 0.8432178230859548 1.0279472990725749 1.0088500451846285 0.5880754551934362 0.5527856635340979 0.6890436518189871 0.8410986788268344 0.7721564405768154 0.744182535359258 1.0 14.847949248726868 -5.746865446816752 24.999792356756174 0.7257129814372755 0.9667993552276126 0.3790296572730386 0.12728618992701263 235.04977357297813 403195.7335163046 0.03540836388366873 0.060987770859772354 1.7911607057643614e-06 5.746865446816752 0.24108637379033715 T(ph)SIIEAQYLR ddPTM_A459_Selumetinib_30min_R1 1 TSIIEAQYLR 10 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 T(0.931)S(0.069)IIEAQYLR 103.46 0.021088 0.0 1248.2 1597.1 1506.5 1514.5 1200.9 1014.7 1206.7 1080.7 715.82 972.77 True False 1277.2806314255924 1410.1107895283528 1301.9255746121578 1250.0210056859855 1092.2788070361148 1004.4930392738856 1115.6776474802566 1052.0363253916707 1214.6942585757329 1097.6345050822042 1.1636666171768482 1.2846815428991516 1.1861193945562543 1.1388317330570514 0.9951206908845415 0.9151434604350899 1.0164382062649362 0.9584577748973748 1.106647297394101 1.0 10.100182024354446 -6.068475788173151 2.4007590749692653 0.9924306256855908 1.2197349600031036 0.7632283970354422 0.05414091198389203 0.133825279846389 1.5248091601223617 0.016974181360485202 0.024705432565076374 8.541304636865634e-07 6.068475788173151 0.22730433431751274 T(ph)SIIEAQYLR ddPTM_A459_Selumetinib_30min_R2 1 TSIIEAQYLR 10 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 T(0.998)S(0.002)IIEAQYLR 135.1 0.0058606000000000005 0.0 10291.0 10489.0 15070.0 11823.0 9963.4 9579.5 7842.7 11171.0 8379.0 10066.0 True False 9719.067418137034 11293.47257254923 14100.412606975397 10212.687004187399 8711.708618073879 10898.98917095713 8207.401090015226 11203.5057605414 10055.034128821035 9775.36842539111 0.9942405232412687 1.1552989187819158 1.4424430868866451 1.0447367873788134 0.8911897985804381 1.1149440815598788 0.8396001800501806 1.1460954997297865 1.0286092238430118 1.0 13.254935362066036 -5.976393693585496 24.99994652942237 1.0044491507609807 1.2015356037505724 0.30055898874812637 0.13267429398939298 278.28362684475974 294710.5071806883 0.037140030510848264 0.05508464651098727 1.0558599245198807e-06 5.976393693585496 0.1970864529895917 T(ph)SKAETPTESVSEPEVATK ddPTM_A459_Selumetinib_30min_R1 1 TSKAETPTESVSEPEVATK 19 1 P18858-3;P18858;M0R0Q7;P18858-2;B4E135 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 T(0.323)S(0.09)KAET(0.261)PT(0.316)ES(0.011)VSEPEVATK 91.481 0.0034088 24092000.0 1982.8 4176.9 7625.2 8393.2 5134.0 4909.9 3342.8 3248.8 2437.7 2209.0 True False 2028.995382142818 3687.8666062118714 6589.739722225445 6927.485179876936 4669.630606481317 4860.510863832511 3090.6499046962795 3162.631270410343 4136.598857436316 2492.5466674821296 0.8140250325553293 1.4795576966818462 2.6437778711209186 2.77928003124403 1.8734375838982344 1.9500179985566344 1.2399566856729425 1.2688353288105558 1.6595873254461238 1.0 11.283404800846144 -7.2555161834453505 21.77618288151384 1.3144977389404753 1.9725611741883615 0.24332669352625858 0.5406067342768951 129.56284604409515 476331.90466509433 0.23150587069769027 0.17377402817054938 5.55243926257637e-08 7.2555161834453505 0.6580634352478862 T(ph)SLAGDTSNSSSPASTGAK ddPTM_A459_Selumetinib_30min_R2 1 TSLAGDTSNSSSPASTGAK 19 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 T(0.844)S(0.156)LAGDTSNSSSPASTGAK 136.39 0.00041141 4741300.0 48813.0 46283.0 40367.0 52304.0 46907.0 38612.0 51305.0 50837.0 37465.0 43734.0 True False 46100.16887392121 49832.757276699034 37769.83116826647 45180.10497056738 41014.123306099435 43930.452515162244 53690.78415892888 50984.927253481575 44959.0468595632 42471.28578542169 1.085443212311343 1.1733281993973483 0.8893027481930156 1.0637800136033435 0.9656906436342827 1.0343565470824858 1.2641666755791579 1.2004564097982218 1.0585751297172978 1.0 15.374200165375616 -7.07639010281521 24.959364697406116 1.1477556859533025 1.0329543075581615 0.17939428442737348 0.09730575981560557 181.05445980816526 59155.52907245522 0.03717225811672596 0.028793514843481582 8.387062844002852e-08 7.07639010281521 -0.11480137839514093 T(ph)SLDLELDLQATR ddPTM_A459_Selumetinib_30min_R1 1 TSLDLELDLQATR 13 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 T(0.974)S(0.026)LDLELDLQATR 98.582 0.028602 0.0 793.55 1024.1 901.86 852.52 1104.2 646.7 804.18 915.23 582.53 834.83 True False 812.0381710204927 904.1978959088268 779.3923655623772 703.6433857823812 1004.3253049623436 640.1947851566192 743.5200551509679 890.9551273139804 988.5108636921603 941.9885624328226 0.8620467417600972 0.9598820325096136 0.8273904765355993 0.7469765704639977 1.0661756894038366 0.6796205502784693 0.7893090052290223 0.945823721057673 1.049387331348469 1.0 9.879565732604691 -7.979301258190203 4.912391362523398 1.0185544438622411 0.8493426236355209 0.3321250151390236 0.10208139979002695 0.21481293712341054 13.767780543276343 0.06258108609768313 0.027011689875781588 1.0488146422601671e-08 7.979301258190203 -0.1692118202267202 T(ph)SMCSIQSAPPEPATLK ddPTM_A459_Selumetinib_30min_R1 1 TSMCSIQSAPPEPATLK 17 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;P20810;P20810-8;P20810-4;B7Z574;E7EVY3;E7ES10;E9PDE4;H0Y9H6;A0A0A0MR45;H0Y7F0;E7EQA0;H0YD33;E7EQ12;P20810-5;E9PCH5;P20810-2;P20810-3 P20810-6;P20810-5 CAST Calpastatin 1 T(0.573)S(0.423)MCS(0.004)IQSAPPEPATLK 104.16 0.0093367 0.0 1501.8 1610.6 2113.3 1694.9 1335.7 1683.9 1685.3 1572.0 1037.1 1216.4 True False 1536.7890180058937 1422.0302032523741 1826.325467525971 1398.9175322133885 1214.886170836988 1666.9614948588705 1558.1764641571858 1530.305453424359 1759.882953212948 1372.5367887393677 1.1196705477143434 1.0360598090477886 1.3306204121518623 1.0192204272340495 0.8851392405684244 1.2145113402679157 1.135252968766194 1.1149467657110284 1.2822118632093975 1.0 10.422629103634305 T(ph)SPADHGGSVGSESGGSAVDSVAGEHSVSGR ddPTM_A459_Selumetinib_30min_R1 1 TSPADHGGSVGSESGGSAVDSVAGEHSVSGR 31 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 T(0.448)S(0.448)PADHGGS(0.103)VGS(0.002)ESGGSAVDSVAGEHSVSGR 146.8 1.2077e-19 6613600.0 377.07 503.68 359.99 413.1 606.65 541.17 425.21 379.47 213.53 262.92 True False 385.85499734950196 444.70891144552064 311.10533528352533 340.95983984739553 551.7786146127564 535.7263211430458 393.1360673614648 369.40522290772384 362.3448143858458 296.66834305767384 1.300627472997649 1.4990103320834167 1.0486637437518733 1.1492963365528732 1.8599174044852094 1.8058088558471432 1.3251702669368979 1.245179108429205 1.2213801130624986 1.0 8.212707177427523 -8.249603454718272 1.4664027180997101 1.0317688439713564 1.432311440874645 0.23313505884235208 0.24362160902466362 0.6557269155344921 2.694785778601162 0.2546207965808741 0.07853450763294365 5.6285502187547744e-09 8.249603454718272 0.40054259690328853 T(ph)SPADHGGSVGSESGGSAVDSVAGEHSVSGR ddPTM_A459_Selumetinib_30min_R2 3 TSPADHGGSVGSESGGSAVDSVAGEHSVSGR 31 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 T(0.5)S(0.5)PADHGGSVGSESGGSAVDSVAGEHSVSGR;T(0.5)S(0.5)PADHGGSVGSESGGSAVDSVAGEHSVSGR;T(0.5)S(0.5)PADHGGS(0.001)VGSESGGSAVDSVAGEHSVSGR 206.23 6.626799999999997e-54 30129000.0 14602.300000000001 9063.0 20199.699999999997 24591.6 26407.800000000003 17262.5 17953.399999999998 18230.100000000002 19677.3 18430.7 True False 13790.76262363837 9758.10295786193 18900.07329377045 21242.181657123823 23090.21607527263 19640.25268162716 18788.26867398719 18283.146572844475 23613.309829699258 17898.55780229046 0.7704957447394774 0.545189342384513 1.0559550944016185 1.1868096799623422 1.2900601450870974 1.0973092300829856 1.0497085229728886 1.0214871373885106 1.3192856145469714 1.0 14.127555724843072 -5.359893063774259 4.895369187725895 1.137882091892549 0.6603346744492916 0.7358028358004758 0.11316477949003538 0.10012585137596866 3.799822004124423 0.02979418994908823 0.06481853233309365 4.366233286623314e-06 5.359893063774259 -0.47754741744325735 T(ph)SPAIESTPEGTPQPAGGR ddPTM_A459_Selumetinib_30min_R1 1 TSPAIESTPEGTPQPAGGR 19 0 Q8NFU5 Q8NFU5 IPMK Inositol polyphosphate multikinase 1 T(0.5)S(0.5)PAIESTPEGTPQPAGGR 91.032 0.0059905 3251800.0 481.39 697.4 787.54 653.13 559.96 525.13 554.97 648.3 436.79 574.72 True False 492.6054503781175 615.748083787536 680.5963936475667 539.0731062685295 509.3117168689673 519.8476689798912 513.1081660910896 631.1049780248167 741.2007281206094 648.4909102468671 0.7596181266297052 0.949509197520029 1.049507992931586 0.8312731878744692 0.7853798855485621 0.801626762635726 0.7912341684107183 0.9731901682084766 1.1429624014906385 1.0 9.340942542457292 -7.984167895568925 5.313809499592913 1.0693063608854876 0.8591740415597898 0.49970691862630234 0.0887830271169929 0.15111215566970887 12.870335225813758 0.05819523750896067 0.0253372797116871 1.037127391251471e-08 7.984167895568925 -0.21013231932569776 T(ph)SPAKQQAPPVR ddPTM_A459_Selumetinib_30min_R1 2 TSPAKQQAPPVR 12 1 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 T(0.98)S(0.02)PAKQQAPPVR;T(0.973)S(0.027)PAKQQAPPVR 136.01 0.014948 21328500.0 2002.19 1589.69 11866.9 11245.0 4637.1 3504.6 3011.9 3496.7 2815.8 1717.0900000000001 True False 2048.8371314164474 1403.5683557731684 10255.44016021575 9281.271844792944 4217.675123746499 3469.346905922204 2784.709958105399 3403.9561571176587 4778.206942104929 1937.4952273729698 1.057466930741525 0.7244241616410341 5.293143443827213 4.790345655394118 2.1768699422631363 1.7906350719770578 1.4372731962189962 1.7568849249414917 2.46617739987089 1.0 10.91997704126634 -6.510050707985837 23.74980051362315 1.750809276929698 3.0363076950461414 0.16162428108251992 1.3640369134138537 659.9631790005852 1221857.7748689498 0.47964997957274885 0.5183151945042381 3.0899346323753195e-07 6.510050707985837 1.2854984181164435 T(ph)SPCQSPTISEGPVPSLPIRPSR ddPTM_A459_Selumetinib_30min_R2 1 TSPCQSPTISEGPVPSLPIRPSR 23 1 J3KQV8;O43426;A0A0D9SGJ6;C9JFZ1;O43426-2;J3KPK1;O43426-4 J3KQV8 SYNJ1 Synaptojanin-1 1 T(0.444)S(0.444)PCQS(0.088)PT(0.022)IS(0.001)EGPVPSLPIRPSR 52.464 0.043082 4347700.0 8398.5 8188.6 6387.9 9618.2 7738.3 8176.7 6417.9 8750.2 4940.0 8363.6 True False 7931.744991859278 8816.639289501069 5976.909468619643 8308.184567679542 6766.145572720259 9302.966204307655 6716.345066827593 8775.661633326405 5928.138035132579 8122.121136757502 0.9765607848377615 1.0855094551102484 0.7358803652374155 1.0229082314569269 0.8330515463626078 1.145386291052237 0.8269200808187994 1.0804642636529067 0.7298755996514475 1.0 12.987640829050164 -8.256384318612726 24.99746678816481 0.8649378092617672 0.9589899619896008 0.0749012194787374 0.13764646710499004 1069.2649708011243 5287626.44094318 0.09198745020392272 0.032253862373899475 5.5413512717122454e-09 8.256384318612726 0.09405215272783363 T(ph)SPDTLR ddPTM_A459_Selumetinib_30min_R1 1 TSPDTLR 7 0 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 T(0.685)S(0.314)PDTLR 127.46 0.012484 127810000.0 6137.5 7867.1 5215.1 5740.5 5766.9 5483.6 6626.2 6021.0 3602.5 6070.0 True False 6280.491808503908 6946.016274684432 4506.918064493771 4738.029437530804 5245.2849132288875 5428.439962710438 6126.380399215775 5861.303521035665 6113.179383810287 6849.143626806938 0.9169747563655436 1.0141437606153187 0.6580265081395134 0.6917696132092455 0.7658307664478388 0.7925720730200498 0.8944739274027875 0.8557717344537855 0.8925465309099151 1.0 12.741707898633914 -8.443253973019988 0.8735881961873234 0.9956368072216163 0.8073817830501161 0.24910382553800858 0.0987977731001129 0.9573955581168835 1.6272926464020516 0.10482448748834122 0.037447021265337166 3.6036784026220013e-09 8.443253973019988 -0.1882550241715002 T(ph)SPDTLR ddPTM_A459_Selumetinib_30min_R2 1 TSPDTLR 7 0 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 T(0.708)S(0.292)PDTLR 116.25 0.02913 744220000.0 1046700.0 946420.0 1025300.0 1062600.0 1086100.0 803960.0 937620.0 1054600.0 791830.0 1013900.0 True False 988528.6042720858 1019007.3707800612 959333.3142622327 917872.0469127566 949654.4081428071 914698.1923777545 981221.1878587838 1057668.711401572 950218.1255787492 984626.0725714315 1.0039634657352334 1.0349181269584302 0.9743123211808269 0.9322036786164505 0.9644822888578473 0.9289802675943217 0.9965419515006793 1.0741831248073532 0.9650548081640544 1.0 19.90921641660099 -7.521816695208046 24.999987141115678 1.0188438872147745 0.9728341266503008 0.1771070016311157 0.0384449992704693 65.0204221802712 1530655.6567242998 0.018698500387722625 0.010963593009838348 3.007345359726947e-08 7.521816695208046 -0.0460097605644737 T(ph)SPENVQDR ddPTM_A459_Selumetinib_30min_R1 2 TSPENVQDR 9 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 T(0.874)S(0.126)PENVQDR;T(0.872)S(0.128)PENVQDR 191.33 0.0046025 59591000.0 7256.1 9059.3 7997.9 7902.3 7923.200000000001 7029.9 8567.8 8061.0 4354.4 7035.2 True False 7425.153012087201 7998.632944445687 6911.8291093200005 6522.311649542667 7206.547958954574 6959.185588638503 7921.5239480246455 7847.196094181779 7389.098767207084 7938.236448651098 0.935365563890317 1.0076083014388986 0.8707008356364203 0.8216323224601061 0.9078273248183661 0.8766664527637043 0.9978946834432865 0.9885314131094207 0.9308237182154828 1.0 12.954602819816154 -7.264608145429487 24.999224465884936 0.9783567401525225 0.9030532352555145 0.3702008786916048 0.04856338284266937 358.02152646860765 2824503.7553481213 0.02169706221260181 0.015324765223348726 5.4374071578101224e-08 7.264608145429487 -0.07530350489700799 T(ph)SPENVQDR ddPTM_A459_Selumetinib_30min_R2 2 TSPENVQDR 9 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 T(0.998)S(0.002)PENVQDR;T(0.999)S(0.001)PENVQDR 182.41 0.0036479 146203000.0 164015.0 138557.0 178394.0 188257.0 196058.0 138087.0 169814.0 187227.0 155308.0 155014.0 True False 154899.70290406616 149183.876369025 166916.32426070145 162616.07183856095 171427.44125924152 157107.23082101948 177710.68748005718 187771.79957290154 186373.93966809104 150538.34304525875 1.028971754109823 0.9910025137195344 1.1087960773589671 1.0802302493104436 1.1387626420712134 1.0436359776710562 1.1805011526307898 1.2473353683483064 1.2380496284063554 1.0 17.199771471560112 -5.96938144988717 0.6551582130015495 1.1726401660021426 0.9997720344874843 0.28529388460275096 0.07513668452092225 1.2175796920201731 0.9850403078397645 0.04591162954897217 0.12876637409310887 1.0730465192176636e-06 5.96938144988717 -0.1728681315146583 T(ph)SPINEDIR ddPTM_A459_Selumetinib_30min_R1 2 TSPINEDIR 9 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 T(0.5)S(0.5)PINEDIR;T(0.848)S(0.152)PINEDIR 178.53 0.0020039000000000003 43822000.0 9497.5 13446.8 7493.4 7746.0 9325.8 9010.7 11191.6 11283.5 6095.299999999999 10630.0 True False 9718.773271082015 11872.442404752283 6475.837438299866 6393.306510428289 8482.28303660372 8920.060539061005 10347.408601591153 10984.22492602656 10343.278916901823 11994.464044968325 0.8102715748403146 0.9898268368008297 0.5399021927133525 0.5330214410964265 0.7071831642333395 0.7436814605153591 0.8626820308767267 0.9157745510633666 0.8623377316505297 1.0 13.550081073909336 -7.326089603870142 2.273323153081282 0.9172027782052918 0.7116182369983513 0.36079437737011844 0.12589295049952606 0.41007269853148953 4.1433793322048 0.0702819431960923 0.04365514735704856 4.719656550107875e-08 7.326089603870142 -0.20558454120694059 T(ph)SPINLGLNVNDLLK ddPTM_A459_Selumetinib_30min_R1 2 TSPINLGLNVNDLLK 15 0 P50616 P50616 TOB1 Protein Tob1 1 T(0.958)S(0.042)PINLGLNVNDLLK;T(0.988)S(0.012)PINLGLNVNDLLK 179.14 4.6542e-05 12442000.0 4167.8 5136.5 4952.799999999999 5292.5 4078.5 4294.8 4829.9 4605.799999999999 2787.7 3552.8 True False 4264.901630872928 4535.116192105932 4280.236963783007 4368.26422752927 3709.6003951176585 4251.598211366397 4465.5767544252 4483.639222253123 4730.523294447726 4008.8364872025854 1.0638751778696336 1.131279912908244 1.0677005603612952 1.0896588677223644 0.9253558749427225 1.060556654016391 1.113933374105097 1.1184390375028392 1.180024006853106 1.0 11.96896785857062 -7.2482551901843015 7.0757446915005975 1.1130610742125127 1.0557728578838301 0.10472678841688277 0.06432626749382879 0.3204775571870807 93.90423717743838 0.026085538232400413 0.019320630054426177 5.646051169850683e-08 7.2482551901843015 -0.05728821632868253 T(ph)SPKPAVVETVTTAK ddPTM_A459_Selumetinib_30min_R2 1 TSPKPAVVETVTTAK 15 1 P56192;H0YI94;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 T(0.5)S(0.5)PKPAVVETVTTAK 84.62 0.029848000000000006 5345800.0 53124.0 35270.0 44143.0 47841.0 42949.0 41293.0 51861.0 50871.0 36993.0 36291.0 True False 50171.580752221504 37975.09558907536 41302.887439264414 41324.973269671784 37553.3626510684 46980.7359294674 54272.639260621945 51019.02618785261 44392.63367078129 35243.184534658125 1.4235825001251747 1.0775160102723031 1.1719397093258466 1.1725663788705822 1.065549641637476 1.3330445744273358 1.539947084158932 1.4476281545352558 1.2596090352483784 1.0 15.105056670004828 -6.8910724342948875 7.552120668325649 1.3611780407226426 1.1758366870057417 0.11749649774288462 0.16233173583977992 0.3439401977194672 21.76289523870293 0.055379961622193136 0.04885140742372078 1.2850723098345188e-07 6.8910724342948875 -0.18534135371690086 T(ph)SPKPAVVETVTTAKPQQIQALMDEVTK ddPTM_A459_Selumetinib_30min_R1 3 TSPKPAVVETVTTAKPQQIQALMDEVTK 28 2 P56192;H0YI94;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 T(0.5)S(0.5)PKPAVVETVTTAKPQQIQALMDEVTK;T(0.5)S(0.5)PKPAVVETVTTAKPQQIQALMDEVTK;T(0.5)S(0.5)PKPAVVETVTTAKPQQIQALMDEVTK 131.26 3.7909e-12 296600300.0 7690.1 9486.6 9945.3 9993.7 8116.5 8132.3 7694.43 7627.700000000001 4907.6 7424.17 True False 7869.264367670209 8375.904461799306 8594.782885622499 8248.487899982854 7382.364008084463 8050.496445537616 7114.032950278866 7425.388617738541 8327.838763077682 8377.134537039747 0.9393742374407412 0.999853162768844 1.0259812406760824 0.98464312152466 0.8812516947702252 0.9610083746348002 0.8492203293171383 0.8863876525925383 0.9941154372364318 1.0 13.03224112809109 -6.1546412201794025 7.11502804356471 0.9207493122036748 0.9919029770088602 0.23857358747502455 0.05014256894721733 0.3230129739621268 18.947115013922694 0.014613470716376888 0.018935510378350333 7.004203890969099e-07 6.1546412201794025 0.07115366480518537 T(ph)SPLKDNPSPEPQLDDIKR ddPTM_A459_Selumetinib_30min_R2 2 TSPLKDNPSPEPQLDDIKR 19 2 Q96JC9-2;Q96JC9 Q96JC9-2 EAF1 ELL-associated factor 1 1 T(0.5)S(0.5)PLKDNPSPEPQLDDIKR;T(0.804)S(0.196)PLKDNPSPEPQLDDIKR 113.71 0.0016874 27522000.0 61071.0 57965.0 60077.0 59114.0 59863.0 46171.0 52884.0 52195.0 34316.0 58647.0 True False 57676.918306583095 62410.7291131487 56211.71122689183 51062.57122266212 52342.47475798986 52530.63615139217 55343.21078765801 52346.87880865257 41180.15886915176 56953.70872679434 1.0126981999233442 1.0958150137777956 0.9869719195379908 0.8965627061726238 0.9190354048596824 0.9223391650117194 0.9717226854029497 0.9191127317056623 0.7230461332499356 1.0 15.7975021703422 -5.561510591861667 3.646126949223221 0.9081003276098601 1.0535787908253924 0.40895861359568897 0.07141733513218912 0.21423020192587847 5.978826579470136 0.0196446240143364 0.03834381929692997 2.7446654039432687e-06 5.561510591861667 0.14547846321553226 T(ph)SPLNSSGSSQGR ddPTM_A459_Selumetinib_30min_R1 2 TSPLNSSGSSQGR 13 0 P51003;G3XAH6;H0YJL4 P51003 PAPOLA Poly(A) polymerase alpha 1 T(0.998)S(0.002)PLNSSGSSQGR;T(0.998)S(0.002)PLNSSGSSQGR 199.38 4.9505e-21 28911000.0 7421.6 10078.5 4630.3 4554.7 6108.3 6568.700000000001 7959.9 7953.8 4313.6 9134.1 True False 7594.508840080262 8898.504534632464 4001.530692417308 3759.3071473079954 5555.805343507953 6502.6248419024105 7359.478334447747 7742.839386416455 7319.864147121183 10306.550708668412 0.7368623174475663 0.8633833749198266 0.3882512011561527 0.3647492991177153 0.5390557423673465 0.630921539679936 0.714058324892148 0.7512541882614786 0.7102147317787656 1.0 13.331273966560964 -8.52623528636684 0.693713118880668 0.991706622563655 0.581223636239937 0.41183110054734495 0.1439203821262243 0.871339523851853 0.9580720188762557 0.16098129041571507 0.06401351734025204 2.976903204908867e-09 8.52623528636684 -0.41048298632371805 T(ph)SPLNSSGSSQGR ddPTM_A459_Selumetinib_30min_R2 5 TSPLNSSGSSQGR 13 0 P51003;G3XAH6;H0YJL4 P51003 PAPOLA Poly(A) polymerase alpha 1 T(0.996)S(0.004)PLNSSGSSQGR;T(0.997)S(0.003)PLNSSGSSQGR;T(0.898)S(0.102)PLNSSGSSQGR;T(0.996)S(0.004)PLNSSGSSQGR;T(0.997)S(0.003)PLNSSGSSQGR 158.31 0.00085277 138606500.0 170194.0 117869.1 151180.8 176993.0 158458.1 155412.1 190399.3 207763.0 178606.4 125728.3 True False 160735.29882056318 126909.28096110838 141453.99192120967 152886.24807004508 138551.1768446125 176818.70608442053 199253.24471905548 208367.55593298379 214332.67067977818 122098.19729764537 1.3164428499196434 1.0394033963641147 1.1585264569990303 1.2521581108797701 1.134752026738436 1.4481680319438297 1.6319097998910261 1.7065571854843602 1.7554122454182337 1.0 16.897682374443157 -6.903475050861017 3.621676129357283 1.5793481745746494 1.1749878921043433 0.3741779756898824 0.20824499212313508 0.2090637033676551 5.328562296259461 0.07364681601092869 0.06394611888223878 1.2488921882829785e-07 6.903475050861017 -0.4043602824703061 T(ph)SPLVSQNNEQGSTLR ddPTM_A459_Selumetinib_30min_R1 3 TSPLVSQNNEQGSTLR 16 0 A0A1W2PNZ9;Q15652-3;Q15652;H7BXU7 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 T(0.887)S(0.113)PLVSQNNEQGSTLR;T(0.997)S(0.003)PLVSQNNEQGSTLR;T(0.986)S(0.014)PLVSQNNEQGSTLR 227.91 9.379600000000001e-15 29694800.0 5147.7 6087.6 4115.3 4613.7 4783.9 4433.6 5837.5 5356.0 2705.55 4996.9 True False 5267.631394319439 5374.860961951544 3556.464863724803 3808.00390487516 4351.197089666146 4389.002009386713 5397.172675201787 5213.941481260097 4591.120744446337 5638.300788927771 0.9342586696800153 0.9532767341016006 0.630768913696272 0.6753814752758737 0.7717213487813247 0.7784263688105517 0.9572339038386353 0.9247363126669279 0.814273824032617 1.0 12.461044728714315 -7.252305991670957 24.231342493060943 0.9177890363809037 0.7846658550863995 0.28602397237587307 0.10282007708195029 639.2282169255589 1695908.5678782875 0.0434291989878034 0.03312153329446313 5.593633509458365e-08 7.252305991670957 -0.13312318129450418 T(ph)SPLVSQNNEQGSTLR ddPTM_A459_Selumetinib_30min_R2 4 TSPLVSQNNEQGSTLR 16 0 A0A1W2PNZ9;Q15652-3;Q15652;H7BXU7 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 T(0.998)S(0.002)PLVSQNNEQGSTLR;T(0.994)S(0.006)PLVSQNNEQGSTLR;T(0.984)S(0.016)PLVSQNNEQGSTLR;T(0.872)S(0.128)PLVSQNNEQGSTLR 304.03 5.338099999999997e-88 76878000.0 116132.0 91650.0 99772.0 115742.0 120189.0 92964.0 112244.0 106310.0 93732.0 97589.0 True False 109677.84835322993 98679.2602988025 93352.77814353998 99977.73993391325 105089.78331670717 105768.9471568307 117463.56840726653 106619.34449943196 112481.01909090007 94771.3520033271 1.1572890544959147 1.0412351223536223 0.9850316173632584 1.0549363053341623 1.1088771141833855 1.1160434553378273 1.2394417292173143 1.1250166030731408 1.1868673044460865 1.0 16.53216339891688 -6.543616572223776 2.3025822662607873 1.1487719392840534 1.053593612264395 0.1843162944834943 0.06990772981285341 0.40866116554098586 4.370439037701983 0.024750862932947083 0.026248735203906724 2.860114552888207e-07 6.543616572223776 -0.09517832701965845 T(ph)SPNSLVAYINNSR ddPTM_A459_Selumetinib_30min_R2 1 TSPNSLVAYINNSR 14 0 P10070 P10070 GLI2 Zinc finger protein GLI2 1 T(0.993)S(0.007)PNSLVAYINNSR 109.1 0.010933 3770700.0 25422.0 26462.0 30291.0 27138.0 24235.0 18120.0 23742.0 23508.0 14324.0 26941.0 True False 24009.147012329184 28491.550311259223 28342.110038347128 23441.757584338793 21190.382636351085 20615.8655230172 24846.050043880507 23576.404388041108 17189.20024599982 26163.143328875587 0.9176705837876485 1.0889956895895545 1.0832838272558278 0.8959839912839039 0.809932597547016 0.7879735727420796 0.9496584462945078 0.9011304219711413 0.6570005763423901 1.0 14.675248261079357 -5.89342732493575 4.933535854585602 0.8482275619463745 1.0347217092998164 0.3968124591074249 0.09853963826755129 0.20046713430960567 7.899411620842985 0.02764375196205987 0.04188052867423597 1.2781230734509324e-06 5.89342732493575 0.18649414735344194 T(ph)SPPCS(ph)PANLSR ddPTM_A459_Selumetinib_30min_R2 1 TSPPCSPANLSR 12 0 P49585;C9JEJ2 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 2 T(0.973)S(0.027)PPCS(0.998)PANLS(0.002)R 195.94 0.028249 52417000.0 116950.0 94154.0 107090.0 102740.0 111240.0 86706.0 94801.0 115740.0 79305.0 107080.0 True False 110450.38718794342 101375.30904717352 100199.94599077616 88746.63476361465 97265.03670178224 98648.96446129859 99209.43434461785 116076.7842382116 95168.21596684004 103988.3221727476 1.062142218281596 0.9748720522557014 0.9635692152463224 0.8534288553688448 0.9353457645003975 0.9486542565560471 0.9540439952460146 1.1162482653136994 0.9151817625131463 1.0 16.66606199809727 -7.580744971652327 24.999999216745316 1.016458395874923 0.9518299774508502 0.12183525129805994 0.06579360629457637 148.51387582167612 64160.55939834319 0.03095512954616089 0.017871935240774406 2.6257600012786605e-08 7.580744971652327 -0.06462841842407274 T(ph)SPPCSPANLSR ddPTM_A459_Selumetinib_30min_R1 2 TSPPCSPANLSR 12 0 P49585;C9JEJ2 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 1 T(0.716)S(0.284)PPCSPANLSR;T(0.53)S(0.47)PPCSPANLSR 138.2 0.0029475 144785000.0 7567.6 8513.2 7044.6 7645.1 7365.200000000001 7071.7 6495.5 6318.5 4211.5 6309.799999999999 True False 7743.910356013715 7516.470586320697 6087.982013217933 6310.026801300714 6699.018960431677 7000.565118589865 6005.539205442951 6150.912854619472 7146.607904210136 7119.724292656735 1.0876699767715392 1.0557249518879777 0.8550867650165979 0.8862740384215242 0.9409098842972091 0.9832635128596524 0.8435072705887008 0.863925708606934 1.0037759343548076 1.0 12.797605659376469 -5.158065583546993 5.74400954545582 0.916258832877918 1.0783742838488501 0.5223873320139256 0.05719421164264624 0.16558999135349667 7.564754616364396 0.014591319645780235 0.04031118286951658 6.9491936871114255e-06 5.158065583546993 0.16211545097093216 T(ph)SPPCSPANLSR ddPTM_A459_Selumetinib_30min_R2 2 TSPPCSPANLSR 12 0 P49585;C9JEJ2 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 1 T(0.875)S(0.125)PPCSPANLSR;T(0.997)S(0.003)PPCSPANLSR 141.34 0.002338 155574000.0 84901.0 61048.0 80520.0 77144.0 84364.0 59311.0 60797.0 67449.0 52662.0 50083.0 True False 80182.54230563134 65730.18529974116 75339.43086354736 66636.85411917741 73765.4400962708 67480.55187834831 63624.18096697 67645.26542321689 63195.87149922102 48636.97365873863 1.6485923418720956 1.3514448033082211 1.5490155985478566 1.370086358307056 1.516653577458295 1.3874331974646628 1.308144322740743 1.3908197886211005 1.2993380703050095 1.0 15.56976584222563 -13.126942742918374 0.12671279560382676 1.501708125744485e-11 1.6374562440607763 0.7596097951979522 0.08152659825556417 44.616977974570325 0.5083462119658211 12.313656523181503 0.6799538289686241 7.465471761813404e-14 13.126942742918374 1.6374562440457592 T(ph)SPPLLDR ddPTM_A459_Selumetinib_30min_R1 6 TSPPLLDR 8 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(0.939)S(0.061)PPLLDR;T(0.991)S(0.009)PPLLDR;T(0.99)S(0.01)PPLLDR;T(0.992)S(0.008)PPLLDR;T(0.941)S(0.059)PPLLDR;T(0.989)S(0.011)PPLLDR 178.55 0.00060499 4551852000.0 40606.5 45899.8 38487.4 39059.200000000004 38713.7 36395.200000000004 41710.0 39425.299999999996 21379.7 34225.0 True False 41552.55244350532 40525.83007776189 33261.02247615533 32238.24395199079 35212.05267045886 36029.097332197634 38563.78111908636 38379.61297257721 36279.78938849376 38618.11212973102 1.0759861151139793 1.0493995651994126 0.8612803848210019 0.8347959590487454 0.91180150267755 0.9329585353930294 0.9985931210085531 0.9938241632228783 0.9394501022374667 1.0 15.236990018523493 -9.718874071229642 14.227122597414354 0.99999999999977 0.952262399339383 0.03132074532883 0.07270974670787198 0.0 0.0 0.07809465480980658 0.01894073591629311 1.9104071231776887e-10 9.718874071229642 -0.047737600660387014 T(ph)SPPLLDR ddPTM_A459_Selumetinib_30min_R2 8 TSPPLLDR 8 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(0.941)S(0.059)PPLLDR;T(0.996)S(0.004)PPLLDR;T(0.937)S(0.063)PPLLDR;T(0.924)S(0.076)PPLLDR;T(0.934)S(0.066)PPLLDR;T(0.941)S(0.059)PPLLDR;T(0.995)S(0.005)PPLLDR;T(0.921)S(0.079)PPLLDR 166.07 0.00060499 5733166500.0 615740.0 538704.0 608950.0 642021.0 649229.0 474171.0 523446.0 536232.0 444983.0 566541.0 True False 581519.635802517 580020.8645936273 569770.8199746296 554576.6322520009 567667.048839099 539483.7511542263 547787.2761885716 537792.3463420135 533992.0338638462 550183.4892797043 1.0569558104403272 1.054231680694355 1.0356014512914025 1.0079848687899524 1.031777688534936 0.9805524187221866 0.9956447019261342 0.9774781628690581 0.9705708082278954 1.0 19.06955332021289 -5.947708278798454 0.6330130735632727 0.9802442706752987 1.0674892954399293 0.8107170215363795 0.013101906581137053 0.44235415266205064 0.3268774839022461 0.007933951475992655 0.023320359543891004 1.1279548635880699e-06 5.947708278798454 0.08724502476463059 T(ph)SPQELSEELSR ddPTM_A459_Selumetinib_30min_R1 2 TSPQELSEELSR 12 0 A0A1B0GVY1;Q96PU5-4;Q96PU5-7;Q96PU5;Q96PU5-2;Q96PU5-3;K7ERN1;Q96PU5-9;Q96PU5-6;Q96PU5-5 A0A1B0GVY1;Q96PU5-9 NEDD4L E3 ubiquitin-protein ligase NEDD4-like 1 T(0.978)S(0.022)PQELSEELSR;T(0.988)S(0.012)PQELSEELSR 212.55 8.6542e-06 19318900.0 2366.9 2135.4 2229.2 1995.6100000000001 2415.3 1850.15 2381.98 2765.6 1458.3200000000002 2138.4 True False 2422.0441648143214 1885.3863752794732 1926.4868841190985 1647.1141757391938 2196.83654145585 1831.539170801794 2202.305330856899 2692.2473040651444 2474.662528521365 2412.884469779892 1.0037961598034013 0.7813827801923157 0.7984165459421423 0.6826328389810752 0.9104607240711569 0.7590662519241423 0.9127272185799257 1.1157796147242542 1.0256034051838 1.0 11.236543124846584 -7.560594087080019 4.657234201669176 1.0508465325518488 0.8180280624567934 0.5747137282157873 0.08623839756117593 0.13566555640552722 6.851843154757061 0.04098455304395451 0.023493350028894217 2.75046367034213e-08 7.560594087080019 -0.2328184700950554 T(ph)SPQVLGSILK ddPTM_A459_Selumetinib_30min_R1 2 TSPQVLGSILK 11 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 T(0.867)S(0.133)PQVLGSILK;T(0.969)S(0.031)PQVLGSILK 170.0 0.00090848 185312000.0 14807.2 16870.7 16554.5 17114.0 15141.4 14676.8 16730.9 16174.599999999999 9296.8 13819.5 True False 15152.178950204325 14895.470601024359 14306.489827359435 14125.361169567492 13771.863043431285 14529.164717468175 15468.874742875127 15745.59706549468 15775.990588593322 15593.367438329233 0.9717066573419898 0.9552439945980231 0.9174727578209572 0.9058570078228702 0.8831872331552578 0.9317528606268074 0.9920163046278191 1.0097624600823079 1.0117115915459796 1.0 13.928644895909056 -7.301082148226119 3.6131232674599008 1.0066365288742933 0.9248008444878187 0.7218793812472823 0.02318510317568234 0.14283377159715793 3.9257184708836963 0.011613237300842245 0.007809335066149054 4.999399607489308e-08 7.301082148226119 -0.0818356843864746 T(ph)SPQVLGSILK ddPTM_A459_Selumetinib_30min_R2 2 TSPQVLGSILK 11 0 Q7Z417 Q7Z417 NUFIP2 Nuclear fragile X mental retardation-interacting protein 2 1 T(0.986)S(0.014)PQVLGSILK;T(0.603)S(0.397)PQVLGSILK 156.08 0.0012691 136128000.0 305380.0 264940.0 286190.0 316530.0 341210.0 265940.0 298280.0 284050.0 245800.0 261200.0 True False 288408.2021329988 285260.0460836299 267776.8469801117 273418.0679552938 298344.1493438976 302570.82103704155 312150.61103060684 284876.5384729911 294966.86822582775 253658.47732089832 1.136994139439461 1.1245831367297574 1.0556589703144534 1.0778984043549154 1.176164709711114 1.192827553932941 1.2305940425389816 1.123071231373038 1.1628504252695289 1.0 17.95252785089029 -4.333904830212656 16.31642605116962 1.133786405841736 5.0383504944665285 0.0 0.06543996952112743 3433.6701285090994 295968.9985859891 0.016346696624394735 857.5802828117174 4.6354848901616906e-05 4.333904830212656 3.9045640886247925 T(ph)SPSGGTWSSVVSGAK ddPTM_A459_Selumetinib_30min_R1 2 TSPSGGTWSSVVSGAK 16 0 F8WB06;F8VRK6 F8WB06 ATXN2 1 T(0.629)S(0.371)PSGGTWSSVVSGAK;T(0.998)S(0.002)PSGGTWSSVVSGAK 217.39 2.9543e-10 81229000.0 8615.3 10541.8 10635.5 11988.900000000001 10409.1 9764.8 10321.2 9960.0 5674.4 8557.1 True False 8816.019727544397 9307.561155250143 9191.257516619722 9895.263674525395 9467.598742875865 9666.574977729022 9542.663574354203 9695.828445360445 9629.042358221535 9655.487138212464 0.9130579950393389 0.9639659834887696 0.9519206421232222 1.0248331889298463 0.9805407647851331 1.0011483459464905 0.9883150832015765 1.0041780706214527 0.997261165634381 1.0 13.237133332460948 -4.616631538393406 0.887982512796311 0.9985058759809993 0.8492871585147573 0.7376974193545023 0.01559542017881405 1.3933617463425267 0.7056937578259317 0.005186238366788992 0.21686965531006397 2.4175110153012096e-05 4.616631538393406 -0.14921871746624193 T(ph)SPSGGTWSSVVSGAK ddPTM_A459_Selumetinib_30min_R2 2 TSPSGGTWSSVVSGAK 16 0 F8WB06;F8VRK6 F8WB06 ATXN2 1 T(0.613)S(0.387)PSGGTWSSVVSGAK;T(0.636)S(0.362)PS(0.002)GGTWSSVVSGAK 209.53 1.2546e-07 28057000.0 104253.0 105428.0 116878.0 122389.0 115330.0 90070.0 89761.0 99761.0 76189.0 97935.0 True False 98459.03561782534 113513.98859554945 109358.19672714439 105719.40706719886 100841.2143367184 102476.32492594699 93935.06435804718 100051.2879936774 91428.92889852545 95107.36208431123 1.035240947283796 1.1935352438323443 1.1498394480776368 1.111579637478329 1.0602882061572079 1.0774804671283311 0.9876739539340307 1.0519825784357624 0.9613233601987099 1.0 16.537269401302275 -6.789695987623464 0.9991872093244398 0.998269310586607 1.1327879010466606 0.583844380204732 0.04470814508440787 0.36392768202209363 0.7777079261000875 0.025303801843106755 0.022396196713903423 1.6229457851790068e-07 6.789695987623464 0.13451859046005366 T(ph)SPSGGTWSSVVSGVPR ddPTM_A459_Selumetinib_30min_R1 3 TSPSGGTWSSVVSGVPR 17 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4 Q99700 ATXN2 Ataxin-2 1 T(0.909)S(0.091)PSGGTWSSVVSGVPR;T(0.552)S(0.447)PS(0.001)GGTWSSVVSGVPR;T(0.973)S(0.027)PSGGTWSSVVSGVPR 276.34 1.6636999999999995e-52 280246000.0 6596.1 8018.6 6902.5 7499.0 6697.2 5920.400000000001 7211.900000000001 6701.400000000001 4028.9 6099.8 True False 6749.776296223649 7079.778584253999 5965.178412718504 6189.440423664051 6091.439442486693 5860.8461512931035 6667.900576666001 6523.65710278499 6836.749040786469 6882.768747083517 0.9806774779530081 1.0286236316241137 0.8666829631964854 0.8992660731608548 0.8850274745999364 0.85152449060221 0.9687817245772549 0.9478245372618836 0.993313779964415 1.0 12.748773322576278 -10.185344205744514 6.214531252294074 1.0000000003278366 0.932732275112912 0.10478715517486326 0.055717414851133566 2.551454783122815e-10 1.3939075209092655e-10 0.05813293091230048 0.014099306734008747 6.526131106064662e-11 10.185344205744514 -0.06726772521492463 T(ph)SPSGGTWSSVVSGVPR ddPTM_A459_Selumetinib_30min_R2 6 TSPSGGTWSSVVSGVPR 17 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4 Q99700 ATXN2 Ataxin-2 1 T(0.941)S(0.059)PSGGTWSSVVSGVPR;T(0.897)S(0.103)PSGGTWSSVVSGVPR;T(0.982)S(0.018)PSGGTWSSVVSGVPR;T(0.856)S(0.144)PSGGTWSSVVSGVPR;T(0.865)S(0.135)PSGGTWSSVVSGVPR;T(0.92)S(0.08)PSGGTWSSVVSGVPR 276.14 2.6047999999999994e-52 198754900.0 254798.0 277231.0 252744.0 277474.0 282828.0 223810.0 228302.0 227712.0 197893.0 254914.0 True False 240637.347197209 298493.72626183653 236482.7262068601 239681.56253065192 247296.61812559929 254637.79595510362 238918.4953718306 228374.6042202493 237477.12959240755 247553.9704738871 0.9720601400032576 1.2057723238711808 0.9552774522427026 0.9681992256954506 0.9989604192257746 1.028615277176351 0.9651167982257532 0.922524505598019 0.9592943677607364 1.0 17.917383563050358 -5.30555243262691 24.998583694996842 0.9741921361418405 1.0889165178416107 0.3738856420335722 0.05909283424707831 380.48073799401215 215615.2476150318 0.014689997346514922 0.03057989752380147 4.948203673614456e-06 5.30555243262691 0.11472438169977017 T(ph)SPSGGTWSSVVSGVPRLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 TSPSGGTWSSVVSGVPRLSPK 21 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4 Q99700 ATXN2 Ataxin-2 2 T(0.742)S(0.257)PS(0.003)GGT(0.001)WS(0.003)S(0.001)VVS(0.138)GVPRLS(0.856)PK;T(0.718)S(0.279)PS(0.004)GGT(0.002)WS(0.003)S(0.001)VVS(0.063)GVPRLS(0.929)PK 74.058 0.011283 34647000.0 5068.5 4526.3 9631.9 9552.7 5732.5 5889.6 5051.4 5123.6 3417.3 4182.6 True False 5186.586188415815 3996.358691780216 8323.940884239526 7884.5002713876 5213.99638715508 5830.355971328943 4670.368831094529 4987.705484201685 5798.908510283108 4719.477451974083 1.0989746727672887 0.8467799099471494 1.7637420602057867 1.6706299270673786 1.104782561250324 1.2353816774546083 0.9895944791813737 1.0568342650128366 1.2287183420820276 1.0 12.204411415609515 -6.419024680394247 22.83994003308299 1.1062882543941093 1.3453994907124678 0.17847045245580329 0.2547847951822548 34.967933909923836 7672.412204497255 0.08646033394909695 0.09803673749520243 3.8104416853072624e-07 6.419024680394247 0.2391112363183585 T(ph)SPSPDSLGLPEDPCLGPR ddPTM_A459_Selumetinib_30min_R2 2 TSPSPDSLGLPEDPCLGPR 19 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 1 T(0.986)S(0.014)PSPDSLGLPEDPCLGPR;T(0.972)S(0.027)PS(0.001)PDSLGLPEDPCLGPR 273.44 2.713699999999999e-130 0.0 17327.4 14955.5 14726.599999999999 19369.0 17493.5 14845.0 20612.0 15296.9 13153.5 14140.8 True False 16364.412475077997 16102.53876048814 13779.106589109728 16730.908786611333 15295.810136125745 16889.764000507184 21570.49884190317 15341.411446461883 15784.567539497251 13732.518361789243 1.191654148492676 1.1725845424895613 1.0033925479721268 1.218342356866248 1.113838680797716 1.2299101705556776 1.570760604400364 1.1171593616178506 1.149429924187674 1.0 13.745308600438776 -5.905530173430016 24.57850364350384 1.217952472552932 1.1247646304887915 0.044782060698349335 0.1480901560456621 41.040427583798554 10652.640504785848 0.043039110795740215 0.06383731059372424 1.2429962733290074e-06 5.905530173430016 -0.09318784206414055 T(ph)SPSVTPTPAR ddPTM_A459_Selumetinib_30min_R1 1 TSPSVTPTPAR 11 0 Q8WXE0-2;Q8WXE0 Q8WXE0-2 CASKIN2 Caskin-2 1 T(0.733)S(0.267)PSVTPTPAR 187.31 4.5121e-05 10951000.0 3228.2 3894.5 3996.8 4429.8 3727.4 3537.6 4264.3 3654.6 1860.1 2926.8 True False 3303.4107790162643 3438.530129496069 3454.0565128508974 3656.2185876446188 3390.2573281259206 3502.0149558838034 3942.6404177923714 3557.6681361861706 3156.4538436712046 3302.483289446216 1.0002808461054178 1.0411953151995104 1.045896741972644 1.1071119116117374 1.0265781931312734 1.0604186755691491 1.1938411408142209 1.0772705943904248 0.955781927423621 1.0 11.689335546120846 -4.8113676935024605 1.499503777959838 1.0673368529494391 0.9776772770169971 0.06587156954120055 0.06058151473889485 2.734841884677032 6.007786670662084 0.017826518125131873 0.36212491608081876 1.5439467103706536e-05 4.8113676935024605 -0.089659575932442 T(ph)SPTPGDFPK ddPTM_A459_Selumetinib_30min_R2 3 TSPTPGDFPK 10 0 Q9UPU7;C9JW56;Q9UPU7-2 Q9UPU7 TBC1D2B TBC1 domain family member 2B 1 T(0.998)S(0.002)PTPGDFPK;T(0.62)S(0.38)PTPGDFPK;T(0.688)S(0.312)PTPGDFPK 161.67 0.00098591 29461400.0 258964.0 234832.0 253830.0 264021.0 238369.0 180417.0 228382.0 218918.0 164444.0 214561.0 True False 244571.81759502878 252842.85929610892 237498.8541492083 228060.88433837082 208422.95517410213 205267.80408753818 239002.21553034752 219555.01513617433 197337.39494925976 208366.0664335727 1.1737603045503502 1.2134550679187268 1.139815413393731 1.0945202750231733 1.000273023057464 0.985130676990429 1.147030414410312 1.053698516721621 0.9470706930687829 1.0 17.668760820315477 -5.79676804338003 2.0282778694578965 1.02982946006498 1.1914554992512432 0.6401581901932714 0.05187971137637028 0.2194473649486282 1.8438578091769833 0.0166986891970166 0.031671523507063606 1.5967317337213406e-06 5.79676804338003 0.16162603918626317 T(ph)SPTPPESATTVK ddPTM_A459_Selumetinib_30min_R1 4 TSPTPPESATTVK 13 0 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 T(0.992)S(0.008)PTPPESATTVK;T(0.872)S(0.128)PTPPESATTVK;T(0.988)S(0.012)PTPPESATTVK;T(0.987)S(0.013)PTPPESATTVK 236.28 3.2839e-17 524132000.0 25412.0 26383.4 29498.1 30464.300000000003 26725.7 24616.6 25174.899999999998 23696.3 13782.6 19823.0 True False 26004.050156855625 23294.4192626901 25492.42004146493 25144.28189073594 24308.365153805575 24368.97935408447 23275.93702457174 23067.797147569745 23388.065558724124 22367.475142371324 1.1625831700420866 1.0414416072631658 1.1397093270117886 1.1241448456157859 1.086772869940853 1.0894827958441156 1.0406153075578697 1.0313098371962324 1.0456283246033196 1.0 14.449114792622305 -7.211499293505095 1.1077638617409251 1.0218334375029636 1.1129676896592844 0.6122511589157291 0.0313290466750775 0.35720450856105274 0.8617665872574803 0.020456051824920083 0.01213291441717534 6.144700313030659e-08 7.211499293505095 0.09113425215632076 T(ph)SPTPPESATTVK ddPTM_A459_Selumetinib_30min_R2 5 TSPTPPESATTVK 13 0 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 T(0.991)S(0.009)PTPPESATTVK;T(0.839)S(0.16)PTPPESATTVK;T(0.6)S(0.4)PTPPESATTVK;T(0.867)S(0.133)PTPPESATTVK;T(0.985)S(0.015)PTPPESATTVK 246.63 2.4752999999999997e-22 596503600.0 408680.0 365205.0 400079.0 419720.0 392173.0 313174.0 346673.0 327153.0 260188.0 356511.0 True False 385967.20167566295 393215.04918084026 374338.35271307884 362553.41194261506 342904.7216688967 356310.87578948034 362793.98141951737 328104.96106690494 312232.8702601376 346217.60110317945 1.1148110334247199 1.1357454038382488 1.0812227671854235 1.0471836520944735 0.9904312217988724 1.0291529796698375 1.047878502605065 0.9476842310195646 0.9018399678850708 1.0 18.401319545122853 -5.829089484432728 0.4812251549755207 0.9570569169117875 1.1731503091258708 0.7132464949170076 0.03682053180301125 1.089353218504213 0.39136390002018473 0.031325851453634514 0.12120052599183617 1.4822126504027332e-06 5.829089484432728 0.2160933922140833 T(ph)SPTVATQTGASATSTR ddPTM_A459_Selumetinib_30min_R1 4 TSPTVATQTGASATSTR 17 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.846)S(0.154)PTVATQTGASATSTR;T(0.98)S(0.02)PTVATQTGASATSTR;T(0.857)S(0.143)PTVATQTGASATSTR;T(0.856)S(0.144)PTVATQTGASATSTR 249.89 3.8244e-30 190940000.0 14503.4 17790.0 19188.800000000003 19680.199999999997 17194.899999999998 14612.3 16905.1 16069.900000000001 9252.6 14228.8 True False 14841.301001296219 15707.13852965337 16583.06635653355 16243.422513107504 15639.624331006169 14465.313528906865 15629.934696625907 15643.674049608217 15700.986416833599 16055.205080248857 0.9243918671306176 0.9783206412589721 1.032877890605961 1.0117231409949532 0.974115512871652 0.900973451077378 0.9735119930578702 0.9743677499861458 0.9779374563174519 1.0 13.970753472913872 -6.519222167205661 24.98981145836056 0.9612967085340901 0.9899361160752452 0.06751395687891226 0.03533193771580817 348.1536640186456 2379366.3614163324 0.012132568401969237 0.012391006957383894 3.0253653796027696e-07 6.519222167205661 0.028639407541155126 T(ph)SPTVATQTGASATSTR ddPTM_A459_Selumetinib_30min_R2 3 TSPTVATQTGASATSTR 17 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.985)S(0.015)PTVATQTGASATSTR;T(0.995)S(0.005)PTVATQTGASATSTR;T(0.998)S(0.002)PTVATQTGASATSTR 244.18 1.1258e-22 118330000.0 108084.0 108604.0 109095.0 129139.0 119294.0 90236.0 93642.0 95535.0 73845.7 92319.0 True False 102077.12397453337 116933.57758310006 102075.94647365499 111550.0454227994 104307.22121810884 102665.1899191489 97996.53854810273 95812.99103332942 88616.9034212529 89653.5105964315 1.138573640847438 1.304283310326438 1.1385605069403488 1.244235107813385 1.1634482634778232 1.1451329595032647 1.09305857513184 1.0687031706390657 0.9884376287299578 1.0 16.452072455904677 -7.4647017176442185 0.8222643470577237 0.9900420710583718 1.2118650903426043 0.7426259848881623 0.04730788320921647 0.29300425910371763 0.3723003709592199 0.03741413832959555 0.019469774095274357 3.430032873551559e-08 7.4647017176442185 0.22182301928423243 T(ph)SPTVFSEDQLSK ddPTM_A459_Selumetinib_30min_R1 1 TSPTVFSEDQLSK 13 0 O95936-3;O95936-2;O95936;O95936-4 O95936-3 EOMES Eomesodermin homolog 1 T(0.608)S(0.391)PT(0.001)VFSEDQLSK 147.73 0.0011243 0.0 1357.6 1724.9 1650.3 1728.5 1772.0 1474.9 1456.6 1415.0 1073.8 1432.3 True False 1389.2294385702496 1522.947906115745 1426.1983244490173 1426.6499229635042 1611.7229128720094 1460.063845102053 1346.7274892846115 1377.4696034322312 1822.1601727510022 1616.1496567834547 0.8595920759808633 0.9423309900314524 0.882466743387807 0.8827461720363802 0.9972609319360587 0.903421189351949 0.8332938002566784 0.8523156241444515 1.127469950015372 1.0 10.658345083681459 -8.257400839713586 24.997343662000738 1.063734980174298 0.8967267451875057 0.6202616929916933 0.05303759402439162 212.12654042789973 1313019.5956279137 0.03935887997340094 0.013670886150544907 5.528396206400272e-09 8.257400839713586 -0.16700823498679218 T(ph)SPTVFSEDQLSK ddPTM_A459_Selumetinib_30min_R2 2 TSPTVFSEDQLSK 13 0 O95936-3;O95936-2;O95936;O95936-4 O95936-3 EOMES Eomesodermin homolog 1 T(0.834)S(0.165)PT(0.001)VFSEDQLSK;T(0.84)S(0.148)PT(0.008)VFS(0.004)EDQLSK 115.37 0.009393899999999998 5349100.0 42320.0 40931.0 45880.0 47505.0 41554.0 38693.0 35471.0 32396.0 29083.0 38790.0 True False 39968.02382038278 44070.2760860914 42928.13075036702 41034.73704930409 36333.61502252664 44022.60952991744 37120.47178445309 32490.26699655351 34900.41264691514 37670.031911476355 1.061003184555475 1.1699028073471098 1.139583073655129 1.0893204748468148 0.9645230752102822 1.1686374366066237 0.9854112115350813 0.8624964022569674 0.9264768537741154 1.0 15.201129634987906 -7.476175754232983 5.49778514165215 0.9207120432833921 1.0967040690520837 0.59343677126613 0.06400984094840366 0.1349833589925358 9.835225067463133 0.028428115248355517 0.018357602384766507 3.340598223062748e-08 7.476175754232983 0.17599202576869166 T(ph)SPVIMAR ddPTM_A459_Selumetinib_30min_R2 1 TSPVIMAR 8 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 T(0.938)S(0.062)PVIMAR 138.06 0.0058272 6501000.0 35865.0 29664.0 31532.0 36651.0 28117.0 27033.0 35226.0 41397.0 39566.0 25242.0 True False 33871.76687897042 31939.133415206452 29503.265449445793 31659.070573498462 24584.691090830747 30756.55036885893 36864.078798994786 41517.458416357746 47480.305566408024 24513.197873407746 1.3817767495653832 1.3029362215467801 1.2035665685810557 1.2915112396592963 1.0029165194109806 1.2546935135796402 1.5038461725544772 1.6936777743468736 1.9369282543880295 1.0 14.581271083059079 -7.348855929588297 3.4886258570950903 1.6084134180686465 1.2311391625791026 0.25422714513506695 0.23899375881476675 0.28278627242055493 6.556360176537473 0.10409634891247718 0.06766498619826594 4.478618507104176e-08 7.348855929588297 -0.37727425548954385 T(ph)SPYGSSLDLSTGSSSRPPPK ddPTM_A459_Selumetinib_30min_R2 2 TSPYGSSLDLSTGSSSRPPPK 21 1 J3KNZ9 J3KNZ9 FBRS 1 T(0.492)S(0.492)PY(0.011)GS(0.003)SLDLSTGSSSRPPPK;T(0.461)S(0.461)PY(0.074)GS(0.003)S(0.002)LDLSTGSSSRPPPK 101.53 0.00033218 28110000.0 77228.0 63102.0 64592.0 68088.0 73532.0 66679.0 65379.0 71760.0 59136.0 62590.0 True False 72935.97692817866 67941.72049509027 60436.22104245216 58814.29694164856 64294.252775579494 75863.42699830371 68419.25304603073 71968.80971949243 70964.85239789482 60782.86407165005 1.199943076756019 1.1177775436017863 0.9942970270570127 0.9676131232039186 1.0577693854601893 1.248105500735814 1.1256339116462002 1.184031236742259 1.1675141255970165 1.0 15.891377035400374 -6.698129476793961 24.996181033855592 1.155345548318049 1.0606600438717788 0.16882417835505048 0.08385863293796672 99.51672315683774 39290.52010524593 0.0283556196202963 0.028355610360667326 2.0038745205145247e-07 6.698129476793961 -0.09468550444627022 T(ph)SPYILR ddPTM_A459_Selumetinib_30min_R1 2 TSPYILR 7 0 P49454 P49454 CENPF Centromere protein F 1 T(0.926)S(0.074)PYILR;T(0.695)S(0.305)PYILR 136.27 0.0065848 57267000.0 10955.4 13271.8 12511.3 12837.8 12079.7 11118.1 12788.3 10654.4 5605.3 9954.0 True False 11210.639504502436 11717.931486107573 10812.33417965158 10595.919225351965 10987.093267844251 11006.262008427113 11823.668235080608 10371.810701631355 9511.784705085853 11231.692860170719 0.9981255402965175 1.043291659769395 0.9626629141537294 0.9433946740946503 0.9782223752579761 0.9799290405684955 1.0527058015456534 0.9234414465170575 0.8468700865936318 1.0 13.455287769167889 -7.922833169575486 9.612321488852338 0.9107418069215146 0.991542810273259 0.3149415269810725 0.04687743267387677 0.3412167824497259 39.27186308067264 0.025332527502396982 0.012147158871023148 1.1944468526518783e-08 7.922833169575486 0.08080100335174434 T(ph)SPYILR ddPTM_A459_Selumetinib_30min_R2 1 TSPYILR 7 0 P49454 P49454 CENPF Centromere protein F 1 T(0.993)S(0.007)PYILR 148.99 0.006272 31437000.0 171690.0 177920.0 190170.0 197220.0 183060.0 134440.0 168490.0 140060.0 121800.0 181770.0 True False 162148.15712952573 191565.89189703146 177934.66924144095 170358.29577652365 160062.36622283582 152957.88967518933 176325.11885660118 140467.55141181863 146163.40337634552 176521.82780482236 0.9185728424974764 1.0852249508136926 1.0080037775168562 0.9650834567886208 0.9067567915726233 0.8665097771608884 0.9988856395230697 0.7957517387998699 0.8280188642616838 1.0 17.429487065404594 -6.117620873807896 2.2542217818031762 0.8907866856369335 1.0117178321559956 0.30247390942605124 0.07167478940802043 0.34931889031410424 3.4901234343611645 0.023063924698381436 0.03274304918822596 7.627445728473923e-07 6.117620873807896 0.12093114651906212 T(ph)SSAVWNSPPLQGAR ddPTM_A459_Selumetinib_30min_R1 1 TSSAVWNSPPLQGAR 15 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.465)S(0.069)S(0.051)AVWNS(0.415)PPLQGAR 93.442 0.029161000000000006 9122500.0 2129.9 2738.7 2637.9 2783.1 2219.9 2011.5 2062.3 2161.1 1495.3 1878.0 True False 2179.522525936044 2418.051730812912 2279.687668947502 2297.08383025729 2019.1104369551779 1991.2661362958715 1906.7390506327447 2103.780607757876 2537.4148876090285 2119.0595932690976 1.0285329081159391 1.141096615920346 1.075801584905218 1.084010962954351 0.952833248941467 0.9396933161393174 0.8998043550494003 0.9927897329741207 1.1974249783577484 1.0 11.049208445144643 -6.24547684633296 22.652490431681212 0.9889962210461576 1.0860874996491265 0.21596866151752947 0.07856232886850345 356.31863328533206 505650.7185878694 0.024244987620484677 0.031156228743186506 5.682286848922333e-07 6.24547684633296 0.09709127860296896 T(ph)SSEDNLYLAVLR ddPTM_A459_Selumetinib_30min_R1 2 TSSEDNLYLAVLR 13 0 Q15149-4 Q15149-4 PLEC Plectin 1 T(0.333)S(0.333)S(0.333)EDNLYLAVLR;T(0.474)S(0.474)S(0.052)EDNLYLAVLR 119.17 0.007673100000000001 6695900.0 2049.31 2103.1099999999997 2080.3199999999997 2210.45 2359.51 2026.13 2019.52 1572.97 1076.5 1840.47 True False 2097.0549357368873 1856.8769034906868 1797.8239703797974 1824.4364027854647 2146.092737105326 2005.748971778848 1867.1859804751195 1531.2497258733547 1826.741875550804 2076.712252195941 1.0097956197443512 0.8941426052295894 0.8657068250446138 0.8785215192216849 1.0334088099282994 0.9658290259798605 0.8991067387890327 0.7373432329174119 0.879631674354107 1.0 11.020085615871688 -7.527998926893846 24.98999437203331 0.8487374686734784 0.9366220377559704 0.11462615985396174 0.0787576799131132 234.99582984281918 1146915.536914145 0.0368607592278627 0.02137537046837693 2.9648387153893306e-08 7.527998926893846 0.08788456908249198 T(ph)SSEDNLYLAVLR ddPTM_A459_Selumetinib_30min_R2 2 TSSEDNLYLAVLR 13 0 Q15149-4 Q15149-4 PLEC Plectin 1 T(0.333)S(0.333)S(0.333)EDNLYLAVLR;T(0.861)S(0.129)S(0.01)EDNLYLAVLR 241.76 1.4851e-17 63806000.0 67776.0 64740.0 66762.0 68931.0 77651.0 49926.0 59632.0 59960.0 51235.0 57085.0 True False 64009.2812488247 69705.34982809015 62466.605604969554 59542.47888739245 67895.78717125223 56802.85331689606 62405.00615856632 60134.47367308761 61483.43162550964 55436.80772535777 1.1546350498018616 1.2573839058955356 1.1268074077143557 1.0740603820908083 1.224742007289058 1.0246414908720192 1.1256962426070787 1.0847391136048594 1.1090723681296324 1.0 15.758556563225984 -1.5228787469776683 0.08006348481287476 0.9035505803980982 1.694066609590359 0.42531098275393897 0.05776211935027545 182.69975253052087 1.0704375501139916 1.5949112516211337 15.981780707231453 0.029999999882752544 1.5228787469776683 0.7905160291922607 T(ph)SSESIYSRPGSSIPGSPGHTIYAK ddPTM_A459_Selumetinib_30min_R2 1 TSSESIYSRPGSSIPGSPGHTIYAK 25 1 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 T(0.322)S(0.322)S(0.063)ES(0.074)IY(0.024)S(0.068)RPGS(0.068)S(0.059)IPGS(0.001)PGHTIYAK 55.158 0.018457 4896300.0 1893.8 1825.5 9739.6 10214.0 12409.0 7378.2 2971.5 7445.3 11809.0 7783.0 True False 1788.5501774820636 1965.5099800923479 9112.964739674686 8822.835579867215 10850.070482132476 8394.480077368959 3109.680637915545 7466.964590364235 14171.129971028477 7558.284567337472 0.23663440580302328 0.26004709965355677 1.2056921988695213 1.167306615841695 1.4355202407991088 1.1106329753241944 0.411426774185479 0.9879178964274685 1.8749135263136152 1.0 12.883843121354436 -5.257907756794562 23.868088472311126 1.1318941311319972 0.24834053304076245 0.5173911629530799 0.3476911598792991 131.7034210535137 890082.0685972837 0.09381099463731266 0.22809019017126717 5.5219471178449875e-06 5.257907756794562 -0.8835535980912348 T(ph)SSFTEQLDEGTPNR ddPTM_A459_Selumetinib_30min_R2 1 TSSFTEQLDEGTPNR 15 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71;C9J0Y3;C9JHJ5 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 T(0.533)S(0.08)S(0.08)FT(0.308)EQLDEGTPNR 287.43 1.1158999999999999e-66 147600000.0 209530.0 174870.0 185570.0 211930.0 212790.0 179380.0 173750.0 195950.0 146330.0 210670.0 True False 197885.1614150473 188281.96670432726 173630.6282333392 183064.76840035833 186057.41783326372 204087.96675048696 181829.71927909326 196520.18205873144 175600.08880181145 204587.40971360516 0.9672401722670027 0.9203008482677242 0.8486867714704376 0.8947997760792044 0.9094275062855485 0.9975587795758432 0.8887629963819885 0.9605683083520792 0.8583132708294609 1.0 17.642357838959754 -6.551785412606406 24.99783449998703 0.9373293126983413 0.9041435387236104 0.09721155498445588 0.049094275990812584 526.6909923302522 455467.0435786621 0.015908747430504425 0.015908956155117046 2.80682016131392e-07 6.551785412606406 -0.03318577397473088 T(ph)SSGLGGSTTDFLEEWK ddPTM_A459_Selumetinib_30min_R2 1 TSSGLGGSTTDFLEEWK 17 0 Q96IZ0;A0A0B4J260;F8W1M8 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 T(0.734)S(0.133)S(0.133)GLGGSTTDFLEEWK 201.75 9.6938e-08 1120700.0 14631.0 15790.0 14491.0 17710.0 14845.0 13730.0 12985.0 14090.0 10615.0 14808.0 True False 13817.86759253357 17001.042227147715 13558.664836607855 15297.86744854595 12980.038384016165 15621.182871469433 13588.828229289371 14130.999567274936 12738.296607881039 14380.454564195456 0.9608783596408268 1.1822326026798218 0.9428537029953352 1.0637958195448616 0.9026166958820582 1.0862787961072629 0.9449512300621511 0.9826531911208416 0.8858062553597525 1.0 13.811821659439707 -6.108370176581137 0.6060889395498872 0.9563995294776351 1.0649630697701118 0.12521463942385969 0.08107709730185093 2.0200560691465763 1.4604106697210621 0.05208938897465227 0.1252637759219907 7.791656953320391e-07 6.108370176581137 0.10856354029247672 T(ph)SSGTSLSAMHSSGSSGK ddPTM_A459_Selumetinib_30min_R1 1 TSSGTSLSAMHSSGSSGK 18 0 A6NNK5;Q12888;Q12888-3;Q12888-2;M0R142 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.317)S(0.317)S(0.317)GT(0.021)S(0.021)LS(0.007)AMHSSGSSGK 81.89 0.013628 3339600.0 1070.1 1792.8 1226.3 1532.9 3410.5 1523.2 2898.4 1428.8 448.48 886.61 True False 1095.0312479478664 1582.8981425498907 1059.7751955837298 1265.207791096762 3102.0208771726793 1507.8779909549446 2679.7713544847716 1390.903582603515 761.0378043167904 1000.4150298127348 1.0945769658746956 1.5822414651708996 1.0593355397530428 1.264682909985462 3.1007339801295655 1.5072524362585802 2.678659630879787 1.39032655563349 0.7607220819735656 1.0 9.966382921897182 -6.0785519424233545 24.99993189485011 1.8297605685486817 1.2594186379166905 0.10186185321315888 0.6808732642600434 228.41313114535356 72692.9348331621 0.20151067816190504 0.260149261390844 8.345417295736751e-07 6.0785519424233545 -0.5703419306319912 T(ph)SSIADEGTYTLDSILR ddPTM_A459_Selumetinib_30min_R2 1 TSSIADEGTYTLDSILR 17 0 A0A087WY00;G3V394;F8WE88;F8W6H6;Q9Y4I1-2;Q9Y4I1;Q9Y4I1-3;E7ERV5 A0A087WY00 MYO5A Unconventional myosin-Va 1 T(0.387)S(0.387)S(0.225)IADEGTYTLDSILR 243.99 1.2295e-22 3192100.0 14574.0 13617.0 16377.0 15870.0 18962.0 13618.0 15709.0 17103.0 17042.0 21521.0 True False 13764.035424344482 14661.380114443984 15323.321649929387 13708.478622723 16579.824037569175 15493.7558881042 16439.49962679298 17152.766898445927 20450.876193265067 20899.632811726817 0.6585778586799601 0.7015137656493879 0.7331861658991179 0.6559195918040794 0.7933069536162477 0.7413410574089431 0.786592749015607 0.8207209692613108 0.9785280142237738 1.0 14.351189975187937 -7.984979735197151 0.7642408235343204 1.0151905428305918 0.6992023756441308 0.8838685662902336 0.03873401691547672 0.1925984448222346 0.22514956744102874 0.03569070367264079 0.015289106094584178 1.0351904690230698e-08 7.984979735197151 -0.31598816718646106 T(ph)SSLDTLAAPYLAGHWPR ddPTM_A459_Selumetinib_30min_R1 1 TSSLDTLAAPYLAGHWPR 18 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.96)S(0.02)S(0.02)LDTLAAPYLAGHWPR 265.29 3.5792999999999998e-43 44584000.0 995.89 1017.8 1074.4 793.42 986.06 946.9 1076.9 1019.7 510.07 1097.5 True False 1019.0922993353906 898.6355028376171 928.5023812567558 654.8640913379829 896.8710471030328 937.3750457164109 995.6685659828357 992.6542435475948 865.5515359611691 1238.3748155552896 0.8229271837044164 0.7256571205662538 0.7497749224175022 0.5288092773788691 0.7242323049834263 0.75693968735636 0.8040122856797407 0.801578190285214 0.6989414877377444 1.0 10.274232321913589 -7.004314501659978 2.4304038458703765 0.8100767380801046 0.7035432011984849 0.22998164550697398 0.09809218565551756 0.5120228214651075 6.068956345067498 0.04126861672664964 0.03268640953178237 9.901146770023746e-08 7.004314501659978 -0.1065335368816197 T(ph)SSLDTLAAPYLAGHWPR ddPTM_A459_Selumetinib_30min_R2 1 TSSLDTLAAPYLAGHWPR 18 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.363)S(0.363)S(0.233)LDT(0.041)LAAPYLAGHWPR 221.9 2.1298e-14 10071000.0 50551.0 34525.0 43700.0 55067.0 47879.0 31907.0 39035.0 38600.0 40103.0 39334.0 True False 47741.57779168644 37172.95648462792 40888.38957696246 47566.77960412649 41864.011976309215 36301.89962709212 40850.20484638509 38712.319609426 48124.72057144166 38198.32521799461 1.2498343191548136 0.9731567096851761 1.0704236205021 1.2452582497443776 1.0959645936672575 0.9503531743844855 1.069423976398348 1.0134559405025763 1.2598646746106787 1.0 15.221221765123003 -6.528386992018959 24.994780764166336 1.0560272801395338 1.1250513732950018 0.0985867054363293 0.10673528165160384 403.9762281443975 1833106.3161125788 0.035037559138648804 0.03513954750199277 2.96219065820899e-07 6.528386992018959 0.06902409315546798 T(ph)SSLTQFPPSQSEER ddPTM_A459_Selumetinib_30min_R2 1 TSSLTQFPPSQSEER 15 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3 Q9H6Z4 RANBP3 Ran-binding protein 3 1 T(0.333)S(0.333)S(0.333)LT(0.001)QFPPSQSEER 247.9 1.5707999999999999e-27 9425200.0 55027.0 59877.0 58240.0 62491.0 62132.0 50442.0 53797.0 48202.0 55018.0 64516.0 True False 51968.8196305341 64469.37336509972 54492.90180691747 53979.61799701219 54326.42269287249 57389.92763311442 56298.66709673317 48342.25983972934 66023.13733136108 62653.255447301046 0.8294671882492387 1.028986808503929 0.8697537169916507 0.8615612646403596 0.8670965667309589 0.915992748076535 0.8985752886230651 0.771584165812278 1.0537862216416594 1.0 15.935101853113464 -8.286503736752245 24.998758077955518 1.0268931614233412 0.8857006477647628 0.45768988880218286 0.06358355262952652 808.5751501177066 806450.7847813712 0.059856995154653966 0.015479280889308767 5.170068095246892e-09 8.286503736752245 -0.14119251365857843 T(ph)SSPIPAQHAPRPYASSLEK ddPTM_A459_Selumetinib_30min_R2 1 TSSPIPAQHAPRPYASSLEK 20 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 T(0.333)S(0.333)S(0.333)PIPAQHAPRPYASSLEK 54.764 0.026475 5209400.0 40031.0 34491.0 42401.0 43445.0 39575.0 34263.0 28849.0 32216.0 25186.0 43120.0 True False 37806.23727678976 37136.34879395517 39672.9658227182 37527.71605319474 34603.234695011095 38982.41724145352 30190.535663208997 32309.743226354087 30223.903755637486 41875.01356078526 0.9028352246838246 0.8868378929608823 0.9474138023890885 0.8961839737369867 0.8263456355609644 0.9309230953410229 0.720967782359874 0.7715757077774711 0.721764632070264 1.0 15.353802037209 -7.252111394619967 24.97781622129938 0.784541671601731 0.896745464295286 0.24093342245840133 0.07962417796604722 768.3663671424109 2057481.348624968 0.02891744736672366 0.022093488846963053 5.596140445497363e-08 7.252111394619967 0.11220379269355496 T(ph)SSPLFNK ddPTM_A459_Selumetinib_30min_R2 1 TSSPLFNK 8 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 T(0.492)S(0.254)S(0.254)PLFNK 133.99 0.0068286 35733000.0 228560.0 207180.0 242870.0 257460.0 231980.0 155250.0 182720.0 195190.0 139470.0 197670.0 True False 215857.550198173 223070.03981130273 227244.00861686206 222393.5038567278 202836.59847248692 176634.27828081767 191216.84205281103 195757.97058455594 167367.89711739664 191962.7534916613 1.124476213598122 1.1620485524083333 1.1837921913676517 1.158524243956463 1.0566455980810776 0.9201487010785689 0.9961142907919235 1.0197705910332209 0.8718769348381271 1.0 17.550466886603736 -6.470385416632266 3.125445914351424 0.9652868409074716 1.1592132181181427 0.8219128618158911 0.04277167956161298 0.10311489847892533 2.0038656412415374 0.014192485854211725 0.015622286069417873 3.385435807300891e-07 6.470385416632266 0.19392637721067107 T(ph)SSPRSPPSSSEIFTPAHEENVR ddPTM_A459_Selumetinib_30min_R1 1 TSSPRSPPSSSEIFTPAHEENVR 23 1 I3L2L5;I3L3A7;I3L317;I3L4Q0;C9JLW8 I3L2L5 FAM195B Protein FAM195B 1 T(0.408)S(0.408)S(0.085)PRS(0.098)PPSSSEIFTPAHEENVR 88.98299999999998 0.00011345 35123000.0 1305.8 1426.4 2030.8 1878.6 1770.8 1460.6 1159.0 1342.9 870.77 990.14 True False 1336.2225993555032 1259.3964248846305 1755.0285143859091 1550.5377756894625 1610.6314526601323 1445.907690118693 1071.5756968837468 1307.281929646038 1477.6330914754988 1117.234113780332 1.1960094870664038 1.1272448713754994 1.5708690709841489 1.3878360466840574 1.4416239468470176 1.2941850524293816 0.9591326326922716 1.1701056327600399 1.3225814296662513 1.0 10.125715815514251 -7.021541132054028 22.245109645985632 1.1270628821937112 1.3496254832537338 0.3585359044939541 0.14708814565205924 231.88281698217597 239459.7688208285 0.05846330874028374 0.04585864512336529 9.516097168367457e-08 7.021541132054028 0.22256260106002257 T(ph)SSPRSPPSSSEIFTPAHEENVR ddPTM_A459_Selumetinib_30min_R2 2 TSSPRSPPSSSEIFTPAHEENVR 23 1 I3L2L5;I3L3A7;I3L317;I3L4Q0;C9JLW8 I3L2L5 FAM195B Protein FAM195B 1 T(0.331)S(0.331)S(0.331)PRS(0.008)PPSSSEIFTPAHEENVR;T(0.304)S(0.304)S(0.304)PRS(0.075)PPS(0.004)S(0.005)S(0.005)EIFTPAHEENVR 115.42 6.1623e-06 32283000.0 36261.0 67089.0 59547.0 60042.0 68869.0 40616.0 17250.3 20413.1 14409.599999999999 57980.0 True False 34245.758784284044 72234.51057486478 55715.81084987148 51864.176021772815 60217.06052332837 46210.48532466148 18052.473130820992 20472.498741429376 17291.922637863645 56305.9667498685 0.6082083438228866 1.282892644322344 0.9895187680087493 0.9211133209411406 1.0694614443054387 0.8207031686347771 0.32061385627240213 0.36359377030813855 0.3071063980604512 1.0 15.781000192517892 -7.092748337519539 4.1779350285708405 0.44780284506690066 0.9869423638816822 0.45446794970165394 0.24348803406614883 0.18082943602718005 5.582937319843425 0.09059895223408089 0.07012802026613543 8.077029377406182e-08 7.092748337519539 0.5391395188147816 T(ph)SSTCS(ph)NESLSVGGTSVTPR ddPTM_A459_Selumetinib_30min_R1 1 TSSTCSNESLSVGGTSVTPR 20 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 2 T(0.717)S(0.2)S(0.081)T(0.002)CS(0.995)NES(0.002)LS(0.003)VGGTSVTPR 173.49 1.2337999999999998e-07 3940100.0 734.59 527.98 843.14 780.18 790.85 610.41 631.25 546.29 305.9 742.6 True False 751.7045177366824 466.1638561487571 728.6462190365053 643.9362087924017 719.3177571359079 604.2698296079359 583.6343042777091 531.8006145999955 519.089957947971 837.9199435365455 0.8971078007333492 0.5563345994382882 0.8695893022442731 0.7684937132234718 0.8584564225789133 0.7211546094219214 0.6965275248306035 0.634667570216153 0.6194982730176909 1.0 9.710668602458247 -6.9736825020837045 24.389674496064664 0.7074592333842681 0.7811987437414918 0.02168181202650976 0.13291997954334342 498.0095582080125 461526.9555232136 0.0446152786359704 0.03934578552676123 1.0624720104748586e-07 6.9736825020837045 0.0737395103572237 T(ph)SSTCS(ph)NESLSVGGTSVTPR ddPTM_A459_Selumetinib_30min_R2 1 TSSTCSNESLSVGGTSVTPR 20 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 2 T(0.443)S(0.144)S(0.393)T(0.027)CS(0.992)NES(0.001)LSVGGTSVTPR 128.44 0.032482 3019100.0 15063.0 15820.0 19232.0 15291.0 15712.0 13727.0 15871.0 18409.0 12183.0 16052.0 True False 14225.858761966589 17033.343130682504 17994.634058218366 13208.339421553706 13738.118092937817 15617.76964870072 16609.032947789885 18462.567142225984 14619.94042146158 15588.537051895288 0.912584594346971 1.0926838788000028 1.1543504049362052 0.8473110323042026 0.8812961759787142 1.0018752623615748 1.0654645071886668 1.1843681726362683 0.9378648152030441 1.0 13.928197920349128 -7.192199467871461 5.016728992104719 1.062224917859099 0.9829858689932913 0.0796572687310465 0.10465067365294896 0.548138106969302 26.58819093326239 0.04355828901989121 0.03313509700382026 6.423926039290874e-08 7.192199467871461 -0.07923904886580768 T(ph)SSVLGMSVESAPAVEEEKGEELEQK ddPTM_A459_Selumetinib_30min_R1 1 TSSVLGMSVESAPAVEEEKGEELEQK 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.443)S(0.114)S(0.443)VLGMSVESAPAVEEEKGEELEQK 162.81 3.09e-14 9024300.0 1550.5 1927.8 1914.1 2137.0 1488.3 1731.5 1536.6 1932.6 1333.7 1896.8 True False 1586.6236332521883 1702.092279790094 1654.1757333986945 1763.8130664582047 1353.6835277807072 1714.082682076212 1420.6930248762428 1881.3411700304814 2263.191490406045 2140.272756396605 0.7413184270604142 0.795268862206031 0.7728808061752322 0.8241066757434162 0.632481782396646 0.8008711398831554 0.6637906409966843 0.8790193513456366 1.0574313407681681 1.0 11.063578950085514 -8.028654289115586 4.036194421673418 1.0207701967027503 0.7508414426628901 0.7856301439323409 0.058769938450337546 0.09478577141737893 3.37472270251151 0.03984299815640925 0.015024324339477167 9.361505803814306e-09 8.028654289115586 -0.26992875403986016 T(ph)SSVPEYVYNLHLVENDFVGGR ddPTM_A459_Selumetinib_30min_R2 1 TSSVPEYVYNLHLVENDFVGGR 22 0 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 T(0.324)S(0.324)S(0.324)VPEY(0.029)VYNLHLVENDFVGGR 91.691 0.00047586 1451200.0 1141.7 938.04 2091.1 1071.3 1219.3 720.95 1097.4 2196.4 967.31 2056.1 True False 1078.2488845872167 1009.9846517260069 1956.5609026175334 925.3870919044201 1066.1206333196976 820.2543183675076 1148.4312744568465 2202.7911603664056 1160.7990288996152 1996.7350506106347 0.5400059884046561 0.5058180610477774 0.9798800807444056 0.46345011653970886 0.533931947052094 0.4107977761579636 0.5751545624972312 1.103196520586322 0.5813485512485113 1.0 10.963427197048858 -7.728818299935645 24.37215591609587 0.8817042867825357 0.5738841392027422 0.37373237777371504 0.19085867304718585 152.86034724011185 114206.33086897455 0.08878124549220573 0.05125215803544322 1.8671607098775712e-08 7.728818299935645 -0.3078201475797935 T(ph)SSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPK ddPTM_A459_Selumetinib_30min_R1 1 TSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPK 35 0 O43149 O43149 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 1 T(0.333)S(0.333)S(0.333)VVEEHFQAS(0.001)VSPTEAAPPATGDQSPGLGTQPK 88.531 6.147e-09 4368400.0 2032.9 2138.2 2052.2 2342.5 2373.9 2061.6 2003.7 2158.0 1019.2 1742.9 True False 2080.2626146651883 1887.8585499777869 1773.5225119276945 1933.4263491709623 2159.1811641460854 2040.8621757830313 1852.5592958118764 2100.7628298280956 1729.5079605772225 1966.6181922836588 1.057786723842702 0.9599517371420146 0.9018133356471499 0.9831223756380725 1.0979157889507878 1.037752108564174 0.9420025214252005 1.0682108189941366 0.8794325036568988 1.0 10.941501178442264 -4.745428959643999 24.159768446243188 0.9887943942830232 1.0577870219628327 0.09599323618929756 0.0658150068032171 1642.195121944014 2477865.850724781 0.016651930156629576 0.4000265095793102 1.797095018582056e-05 4.745428959643999 0.06899262767980952 T(ph)SSVVTLEVAK ddPTM_A459_Selumetinib_30min_R1 1 TSSVVTLEVAK 11 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 T(0.788)S(0.007)S(0.143)VVT(0.062)LEVAK 185.25 4.812600000000001e-05 6490800.0 3465.9 4112.8 4448.5 5060.2 3728.1 3520.7 3332.8 3860.0 1997.1 2911.3 True False 3546.648726532577 3631.2714640111512 3844.4181338613903 4176.531061718208 3390.894013249514 3485.284954539834 3081.4042127473267 3757.6202609529446 3388.932837587099 3284.993713463431 1.0796516023749945 1.1054119979373211 1.1702969531129324 1.2713969724206295 1.032237595874858 1.0609715751526454 0.9380243865059164 1.1438744146000859 1.0316405853982846 1.0 11.681674894307466 -6.330070390676912 24.999976423981863 1.0381556454064271 1.1539993415378975 0.4416436897612449 0.0672255676566743 176.17774932299906 64174.90822293169 0.021405798940394065 0.024271897530802933 4.676593366741037e-07 6.330070390676912 0.11584369613147039 T(ph)STGSASSSAAVAASSK ddPTM_A459_Selumetinib_30min_R2 2 TSTGSASSSAAVAASSK 17 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 T(0.861)S(0.139)TGSASSSAAVAASSK;T(0.978)S(0.021)TGSASSSAAVAASSK 197.51 1.6098e-07 7470000.0 44772.0 40313.0 45155.0 48576.0 46188.0 38625.0 48465.0 45603.0 36745.0 50494.0 True False 42283.7514765165 43404.877473274595 42249.77646104671 41959.865001726066 40385.45051404102 43945.243147159985 50718.71853157564 45735.69718001693 44095.02674108231 49036.107020832365 0.8622982949799174 0.8851615699189699 0.8616054378684147 0.8556932340469025 0.8235859852594696 0.896181320603008 1.0343137253948085 0.9326942932192129 0.8992358778063091 1.0 15.581556827487688 -7.010612437825375 23.50132753282127 0.961565804428201 0.8593630403054044 0.6616590145046293 0.03668883297312014 150.80672506853068 333962.91047202767 0.013626188019014655 0.011271131242720906 9.758601018249825e-08 7.010612437825375 -0.10220276412279661 T(ph)STSPPPEK ddPTM_A459_Selumetinib_30min_R2 1 TSTSPPPEK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 T(0.941)S(0.015)T(0.037)S(0.007)PPPEK 107.55 0.029282 47450000.0 114900.0 89579.0 85704.0 106870.0 109690.0 86408.0 127810.0 133440.0 117110.0 93079.0 True False 108514.3179811433 96449.42125811677 80189.89794745961 92314.12163896719 95909.76155895802 98309.91766627319 133753.41825071027 133828.28830781867 140535.2723267972 90391.5674217146 1.2004916064225157 1.0670179089620133 0.8871391462141605 1.021269176673119 1.061047665115693 1.0876005414046663 1.479711239287338 1.480539525146782 1.5547387475995538 1.0 16.4639005702616 -7.203230985249459 5.357008839640201 1.4187265612223237 1.0428331322792632 0.4935692169724869 0.15907309969628652 0.15572725933735923 9.558013296846736 0.06021103906990316 0.0457947420308261 6.26280680434123e-08 7.203230985249459 -0.37589342894306044 T(ph)STSSSSVQAR ddPTM_A459_Selumetinib_30min_R2 1 TSTSSSSVQAR 11 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 T(0.975)S(0.003)T(0.011)S(0.011)SSSVQAR 150.09 0.0014494000000000002 981470.0 5718.3 7773.2 5239.3 5935.7 6522.3 4017.1 3762.2 7492.9 4850.7 5934.6 True False 5400.499778168596 8369.379445222587 4902.209142118525 5127.24742034637 5702.910363898191 4570.419061396927 3937.149754657871 7514.703098483628 5820.975539882111 5763.252678057431 0.9370576096255587 1.4521972075053249 0.8505976426789029 0.8896447382686276 0.989529816315536 0.7930277079118867 0.6831471695918999 1.3038996410992938 1.0100156743160766 1.0 12.492667557794471 -2.456594964435835 8.927387800276174 0.9914187702126497 1.2839798564092146 0.0 0.21861339988806142 0.0 0.0 0.05132440594980017 0.0 0.0034946608569800023 2.456594964435835 0.29256108619656496 T(ph)SVAGTVR ddPTM_A459_Selumetinib_30min_R1 2 TSVAGTVR 8 0 Q96EB6;B0QZ35;E9PC49 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 T(0.5)S(0.5)VAGTVR;T(0.921)S(0.079)VAGTVR 136.99 0.005986 17449200.0 8819.8 9923.3 9124.2 9241.4 7367.6 8118.4 8605.2 7617.9 5129.200000000001 7503.099999999999 True False 9025.284179656663 8761.475422782989 7885.183755643053 7627.562972562865 6701.201880855429 8036.736266917425 7956.102835913737 7415.848545573431 8703.877778054053 8466.195971383047 1.0660377116432709 1.034877464731271 0.9313726946902837 0.9009433514585675 0.7915245410697378 0.9492735927780012 0.9397494297092227 0.8759363202363918 1.0280742150872013 1.0 13.04749816850744 -5.2285024465932555 3.155123017542049 0.9169074396726152 1.0604810207077844 0.3850130046342757 0.06209243587688219 0.24104101381212936 4.833489763754607 0.01652452216668532 0.05056380431462495 5.90877636862644e-06 5.2285024465932555 0.14357358103516915 T(ph)SVAGTVR ddPTM_A459_Selumetinib_30min_R2 1 TSVAGTVR 8 0 Q96EB6;B0QZ35;E9PC49 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 T(0.913)S(0.087)VAGTVR 101.46 0.039792 4739600.0 32942.0 29711.0 39234.0 32396.0 31433.0 38295.0 32239.0 35449.0 30694.0 33395.0 True False 31111.215517274344 31989.73816407765 36709.72715474932 27983.6089137829 27484.10552541462 43569.788642601714 33738.17738036658 35552.15072110213 36833.6576620161 32430.799579369756 0.9593107762000774 0.9863999216481645 1.1319402429442882 0.8628713838922475 0.8474692539772629 1.3434694552001678 1.0403128451334418 1.096246505859139 1.135761625977521 1.0 14.985076973339194 -6.734849150259667 24.99999901984045 1.123995964756437 0.9636215132761543 0.35537161068355416 0.11133989071525165 267.0577275691487 251085.6944389603 0.03706982163409364 0.037060035027722135 1.8414114943036086e-07 6.734849150259667 -0.16037445148028273 T(ph)SVQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R1 1 TSVQTEDDQLIAGQSAR 17 0 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 T(0.982)S(0.018)VQTEDDQLIAGQSAR 251.0 3.1724e-30 7614900.0 2925.5 2724.3 2388.9 2176.8 2606.4 2311.4 3025.4 2696.4 1396.2 2679.6 True False 2993.6584579679306 2405.3376895072915 2064.5005012884067 1796.6627435967343 2370.651580197296 2288.149414583285 2797.1916422364848 2624.882712858423 2369.2494255866527 3023.55276151431 0.9901128553379677 0.7955335591043587 0.68280617674898 0.5942223884649188 0.7840615881993022 0.7567750904526279 0.9251340601165977 0.8681451656043806 0.7835978441467787 1.0 11.562029039147136 -7.248894159875788 23.5002843246117 0.8832313611180975 0.7575981056360118 0.24820156937189586 0.10678663055161508 533.8198586018646 999977.042710678 0.043222720704807885 0.03320467116167804 5.637750343830757e-08 7.248894159875788 -0.1256332554820857 T(ph)SVQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R2 1 TSVQTEDDQLIAGQSAR 17 0 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 T(0.986)S(0.014)VQTEDDQLIAGQSAR 321.6 2.6493e-118 16388000.0 25647.0 19328.0 17996.0 27567.0 22288.0 21419.0 33901.0 29886.0 22963.0 20313.0 True False 24221.642413075566 20810.395450684675 16838.156952563306 23812.327044272526 19487.982182751926 24369.272827676898 35477.4636735571 29972.96331210636 27556.24163982781 19726.51091048773 1.2278726087438996 1.0549455778122776 0.853580089706142 1.207123102120028 0.9879082150503874 1.2353564671551123 1.7984662282418766 1.5194254801628926 1.3969141205390434 1.0 14.267848184203281 -7.0121684844257635 12.958134618552705 1.4784281262928416 1.0666250658743162 0.39219125093605456 0.2090704880939361 0.9764219477913579 1037.1081947642788 0.07423238640482113 0.06087176122250939 9.723699199490914e-08 7.0121684844257635 -0.41180306041852544 T(ph)T(ph)ESTVT(ph)RKT(ph)EPK ddPTM_A459_Selumetinib_30min_R1 1 TTESTVTRKTEPK 13 2 A0A0A0MTS7;Q8WZ42-5;Q8WZ42-11;Q8WZ42-4;Q8WZ42-7;Q8WZ42-2;Q8WZ42;Q8WZ42-8;Q8WZ42-13;Q8WZ42-12;A0A0A0MRA3;Q8WZ42-3;Q8WZ42-10;Q8WZ42-9 A0A0A0MTS7 TTN Titin 4 T(0.993)T(0.994)ES(0.171)T(0.171)VT(0.858)RKT(0.813)EPK 62.287 0.039144 0.0 223.43 442.22 354.53 421.38 407.42 286.25 482.81 356.15 188.85 311.79 True False 228.63548428090078 390.4446768174997 306.3867732938922 347.79389328224545 370.5689329358432 283.3705848942051 446.39125298743875 346.7037450617594 320.46465694172736 351.8112835917849 0.6498810440264106 1.1098128315592688 0.8708838732114123 0.9885808372360196 1.053317361377821 0.8054618999173625 1.268837225543332 0.985482163966202 0.9108993141719985 1.0 8.458657944673442 -4.749922273673561 24.949241272754108 0.9985121804248337 0.6498802556417841 0.4227899384169822 0.1224627102460594 491.2652428446706 1064147.8660158603 0.02932779330331158 0.45548687325129755 1.7785976998193905e-05 4.749922273673561 -0.3486319247830496 T(ph)T(ph)GITTPVASVAFPK ddPTM_A459_Selumetinib_30min_R1 2 TTGITTPVASVAFPK 15 0 Q8IWI9;H3BU53 Q8IWI9 MGA MAX gene-associated protein 2 T(1)T(1)GITTPVASVAFPK;T(1)T(1)GITTPVASVAFPK 145.34 0.0029935 6115300.0 2194.76 2632.7 2727.2 2560.1 2526.8 2284.7 2567.1 2344.8999999999996 1560.46 2389.1000000000004 True False 2245.893637740455 2324.4622600909743 2356.8612194372904 2113.02659402885 2298.251386142772 2261.717992341623 2373.461580215932 2282.705634691337 2647.986648510922 2695.764256804689 0.8331194510318682 0.8622646636194287 0.8742831326916163 0.7838321131735152 0.8525416791700131 0.8389895320529457 0.8804410750030549 0.8467749466331475 0.9822767854521529 1.0 11.396478623759977 -8.288238985634901 4.273609511090846 0.9983952716003933 0.8464325347610838 0.8389573758219613 0.025376363316391506 0.07783213750510341 3.2877506667090914 0.023177874393332718 0.006549910577008396 5.149452001052807e-09 8.288238985634901 -0.1519627368393095 T(ph)T(ph)RPFKT(ph)S(ph)NPK ddPTM_A459_Selumetinib_30min_R1 1 TTRPFKTSNPK 11 2 Q9H244 Q9H244 P2RY12 P2Y purinoceptor 12 4 T(1)T(1)RPFKT(1)S(1)NPK 81.278 0.02532 13562000.0 1095.8 1453.5 858.76 798.03 1062.4 896.83 977.58 1149.3 629.98 992.78 True False 1121.3300079443713 1283.3235442861817 742.1451088310241 658.6690413784003 966.306107581954 887.8087044564882 903.8403535458265 1118.8168305474658 1069.0300480812773 1120.2129834961108 1.0009971536348155 1.1456067401406236 0.6625035772347846 0.5879855447869722 0.8626092732528206 0.7925356316489885 0.8068468825678135 0.9987536718738184 0.9543096391767439 1.0 10.129557339285583 -7.763442467353054 24.983356360282023 0.9823987786367009 0.8318651920290191 0.1712462142492449 0.14821749077280405 106.23220890732692 1324901.385385725 0.0847064674816375 0.043893380670171046 1.7240804714172067e-08 7.763442467353054 -0.1505335866076818 T(ph)T(ph)TSYQRK ddPTM_A459_Selumetinib_30min_R1 1 TTTSYQRK 8 1 H0Y9Y3;Q9UMS6-5;Q9UMS6;Q9UMS6-3;Q9UMS6-4;Q9UMS6-2 H0Y9Y3 SYNPO2 Synaptopodin-2 2 T(1)T(0.576)T(0.399)S(0.025)YQRK 82.287 0.013987 0.0 3069.7 2786.9 3903.5 4373.5 2979.5 2904.4 2992.1 2722.1 1637.8 2599.8 True False 3141.2180374035756 2460.608452405341 3373.4261403906808 3609.750325762732 2710.0047510734503 2875.184372984206 2766.40348804647 2649.901065373059 2779.2269798208135 2933.5096541964845 1.0708054200230626 0.8387933712389041 1.1499625152297968 1.230522735999475 0.9238097264131029 0.9801175765251559 0.9430354129188008 0.9033210651215298 0.9474067950807783 1.0 11.51841202459653 T(ph)TDFSDFLSIVGCTK ddPTM_A459_Selumetinib_30min_R1 2 TTDFSDFLSIVGCTK 15 0 Q9UHD1;E9PIZ4;E9PSD5;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 T(0.881)T(0.118)DFS(0.001)DFLSIVGCTK;T(0.98)T(0.02)DFSDFLSIVGCTK 144.18 0.00063941 966120.0 837.72 653.5699999999999 458.22 386.83000000000004 478.43 315.64 400.25 695.98 342.12 302.42999999999995 True False 857.2372460806343 577.0497205635504 395.9962408222923 319.2774021984218 435.1560909736768 312.4649481781897 370.05882025687623 677.5203495383493 580.5526525438378 341.24983641766397 2.51205174214777 1.6909890027237557 1.1604291007999865 0.9356118835106206 1.2751832954465616 0.9156486387168732 1.0844219711330565 1.9854085694245305 1.701254009784448 1.0 8.414684544233642 -4.838590646673983 2.582517680638209 1.265576191836136 2.686815745766534 0.5805522780727607 0.32581220259073507 0.3378557369172151 3.2465511693904388 0.09394644081434884 1.007420088701026 1.4501380674613304e-05 4.838590646673983 1.4212395539303981 T(ph)TFSPPVVAATVK ddPTM_A459_Selumetinib_30min_R2 2 TTFSPPVVAATVK 13 0 A0A1B0GV05;Q684P5-3;Q684P5-2;Q684P5 A0A1B0GV05 RAP1GAP2 Rap1 GTPase-activating protein 2 1 T(0.985)T(0.007)FS(0.007)PPVVAATVK;T(0.93)T(0.035)FS(0.035)PPVVAATVK 206.46 2.8717e-05 9064300.0 74461.0 69821.0 80162.0 80955.0 83392.0 62497.0 58488.0 56333.0 47083.0 70257.0 True False 70322.75571100003 75176.04619010005 75004.46419378648 69928.78934483556 72915.55142606102 71105.39445872007 61207.80789177335 56496.91970356978 56500.91560893672 68228.49786039178 1.0306947670882847 1.1018276606928126 1.099312846477429 1.0249205469527247 1.0686964203031382 1.042165615374018 0.8971003292057803 0.8280545736060759 0.8281131401214213 1.0 16.058086833379882 -7.264569955156381 3.372796301431672 0.8692849043871523 1.0660535715680872 0.7340243540781641 0.05088882237618385 0.11432398007805407 2.758099381175059 0.021444169114426637 0.014796784725954014 5.437885324592163e-08 7.264569955156381 0.1967686671809349 T(ph)TGTPPDSSLVTYELHSRPEQDK ddPTM_A459_Selumetinib_30min_R1 1 TTGTPPDSSLVTYELHSRPEQDK 23 1 Q13561;Q13561-3;Q13561-2;H0YI98;F8VW18;F8W1I6 Q13561 DCTN2 Dynactin subunit 2 1 T(0.435)T(0.435)GT(0.129)PPDS(0.001)SLVTYELHSRPEQDK 69.975 0.0014788 15449000.0 5164.4 7593.2 4937.0 5195.4 5168.8 5478.2 6336.2 5798.2 3031.2 6293.0 True False 5284.720471826894 6704.18461401709 4266.582516999818 4288.120919736529 4701.282952625758 5423.094281807628 5858.255332696113 5644.412900792058 5143.725009911376 7100.76784901088 0.7442463384524032 0.9441492464721216 0.6008621331838278 0.6038953829949325 0.6620809259776935 0.7637334999711407 0.8250171611387287 0.7949017656700763 0.7243899701111739 1.0 12.79375932506292 -7.030957444020728 4.309270807889855 0.8174927624467412 0.7116363855343328 0.2111614359770163 0.11141712769560663 0.42939429992793554 18.300572597168905 0.04522404563049235 0.03624193626724284 9.311991180475242e-08 7.030957444020728 -0.10585637691240835 T(ph)TGTPPDSSLVTYELHSRPEQDK ddPTM_A459_Selumetinib_30min_R2 1 TTGTPPDSSLVTYELHSRPEQDK 23 1 Q13561;Q13561-3;Q13561-2;H0YI98;F8VW18;F8W1I6 Q13561 DCTN2 Dynactin subunit 2 1 T(0.49)T(0.49)GT(0.021)PPDSSLVTYELHSRPEQDK 102.27 2.0533e-05 17946000.0 78096.0 73357.0 78407.0 74124.0 82324.0 57708.0 75637.0 82390.0 60042.0 58582.0 True False 73755.73696305807 78983.2460200682 73362.37898308698 64028.18332896784 71981.72313410221 65656.75317893352 79154.27037187225 82629.74125960121 72052.07771364988 56890.58544568464 1.296448900732005 1.3883359680922278 1.289534611190256 1.1254618462328483 1.2652659938405026 1.154088196923518 1.391342165874589 1.452432605716294 1.2665026585539434 1.0 15.79590230704442 -5.515473989095852 24.878695008763838 1.2555156146903466 1.3415281660342455 0.0924300627957203 0.12415868153174427 876.8855104435278 2946178.6898946976 0.03421784761053305 0.06259867903036158 3.051588790400777e-06 5.515473989095852 0.08601255134389896 T(ph)THSPYEER ddPTM_A459_Selumetinib_30min_R1 1 TTHSPYEER 9 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 T(0.522)T(0.457)HS(0.021)PYEER 130.98 0.0086824 20485000.0 3830.1 4246.6 4070.3 5159.8 4812.8 3922.2 3832.4 3336.5 1953.7 2914.0 True False 3919.333877922742 3749.406097809221 3517.5756165574962 4258.73779144176 4377.483089768856 3882.746229072663 3543.3189825170584 3248.0051815205943 3315.2862073976835 3288.0402847636587 1.1919969156352535 1.1403163504971245 1.0698091604465656 1.2952206854569832 1.3313349930819067 1.1808694215410902 1.0776385553839858 0.9878240228902968 1.008286371295473 1.0 11.683012259555381 -7.413816022698291 2.7204416012263217 1.0002296921337688 1.2037403940857276 0.6420824188083625 0.06890057237049933 0.20658785523571677 2.9653241958903833 0.03886347392110451 0.02340680866090287 3.856416899085661e-08 7.413816022698291 0.20351070195195886 T(ph)TIFSPEGR ddPTM_A459_Selumetinib_30min_R1 1 TTIFSPEGR 9 0 H0YLS6;H0YLC2;H0YMI6;H0YMA1;H0YMZ1;H0YL69;P25789 H0YLS6 PSMA4 Proteasome subunit alpha type;Proteasome subunit alpha type-4 1 T(0.812)T(0.115)IFS(0.073)PEGR 114.89 0.019503 10765000.0 3068.0 3143.3 3397.3 3393.5 3168.7 2408.2 3170.4 2939.1 2166.3 2640.3 True False 3139.4784307112 2775.2809747194756 2935.9653200331154 2800.8889288843798 2882.091644479424 2383.9756944706523 2931.2541754963154 2861.14552045772 3676.052879708042 2979.208223699895 1.0537962421479439 0.9315498502729155 0.9854851019399121 0.9401454072941369 0.9674018826720807 0.8002044555012606 0.9839037607972144 0.96037111394129 1.2339026357623073 1.0 11.540713245040752 -8.143829523787979 8.078925457944445 1.1160932930575502 0.9485001503579054 0.40279474259605796 0.07987897394169001 0.24977476658482395 15.396325714140922 0.051863618722220964 0.01946744823275276 7.180761066678855e-09 8.143829523787979 -0.16759314269964487 T(ph)TKSPSDSGYSYETIGK ddPTM_A459_Selumetinib_30min_R2 1 TTKSPSDSGYSYETIGK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.351)T(0.351)KS(0.294)PS(0.003)DS(0.001)GYSYETIGK 73.208 0.035498 603780000.0 38924.0 29663.0 33285.0 44282.0 30256.0 21004.0 29041.0 19881.0 24901.0 40847.0 True False 36760.75990511765 31938.056718421973 31143.479337967852 38250.71520928923 26454.97078792813 23897.110344671804 30391.46404364978 19938.850418523274 29881.895792072162 39667.64097674851 0.9267190838665009 0.8051413175072021 0.7851104469817815 0.9642800597018153 0.666915655595323 0.6024333627169631 0.7661525438697998 0.5026477483299444 0.7533066009543563 1.0 15.275674982922675 -6.280394446947843 24.536060475942783 0.6872800553760833 0.8595717522183909 0.23193087649608057 0.13193053528652202 803.5646138712307 1040157.7281216235 0.03855823215373615 0.04379541991219145 5.243310214959019e-07 6.280394446947843 0.1722916968423076 T(ph)TKTPEDGDYSYEIIEK ddPTM_A459_Selumetinib_30min_R1 1 TTKTPEDGDYSYEIIEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.747)T(0.092)KT(0.161)PEDGDYSYEIIEK 99.569 0.0065554 78080000.0 5500.5 6884.8 8444.4 9605.7 6775.1 6558.3 6597.1 6607.5 3959.3 5975.7 True False 5628.650947890145 6078.7244153433185 7297.696861768939 7928.244816320809 6162.293401241054 6492.329456459959 6099.475435644316 6432.247635815174 6718.642924169347 6742.739303247148 0.8347721444872586 0.9015214947456065 1.082304466117285 1.1758195682432433 0.9139154168801151 0.962862297424639 0.9045990303535759 0.9539517021987713 0.9964263220044416 1.0 12.719119104012318 T(ph)TKTPEDGDYSYEIIEK ddPTM_A459_Selumetinib_30min_R2 1 TTKTPEDGDYSYEIIEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.45)T(0.178)KT(0.372)PEDGDYSYEIIEK 78.456 0.025982 27448000.0 19731.0 21016.0 18023.0 21302.0 20624.0 13974.0 16176.0 16721.0 12487.0 21772.0 True False 18634.430009451156 22627.859622909218 16863.419801958695 18400.63085200033 18033.028739100675 15898.79165665796 16928.21605213592 16769.655341689424 14984.74891593128 21143.385789550484 0.8813361395818021 1.0702098447303738 0.7975742376272091 0.8702783478081508 0.8528921961029055 0.7519510741990758 0.8006388485094098 0.7931395429570863 0.7087204038691413 1.0 14.367918800294227 -5.2799915568513995 24.60347905656581 0.8140887034931458 0.9757729958077545 0.3389896565345967 0.08539244827486443 576.2372278894492 764192.4118954017 0.02114242083387788 0.04414788344471336 5.24817663166527e-06 5.2799915568513995 0.16168429231460868 T(ph)TPAPVNQTDR ddPTM_A459_Selumetinib_30min_R2 2 TTPAPVNQTDR 11 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6;Q8NEY1-5;H0Y6F6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 T(0.99)T(0.01)PAPVNQTDR;T(0.999)T(0.001)PAPVNQTDR 114.86 0.014836000000000004 4733800.0 57105.0 42974.0 45419.0 53178.0 49069.0 35256.0 45644.0 40686.0 36587.0 36081.0 True False 53931.33270942717 46269.96761681101 42496.79098846817 45935.064662833254 42904.513537574225 40112.19397789703 47766.536441870136 40804.38952407012 43905.42232619349 35039.247780303645 1.5391692495106357 1.3205182915718985 1.2128339984614789 1.3109603536824326 1.22447016575772 1.1447789698397866 1.363229505991872 1.1645338330295774 1.2530355275170526 1.0 15.096684183162216 -1.5228787452803376 0.06470304492236291 0.7400190371057933 2.384953401828628 0.5662576299198978 0.09028576162831142 241.3347882216624 1.164905689350012 5.602229110794943 36.75523602721342 0.029999999999999995 1.5228787452803376 1.6449343647228347 T(ph)TPCSSAIINPLSTAGNSER ddPTM_A459_Selumetinib_30min_R2 1 TTPCSSAIINPLSTAGNSER 20 0 O43353-2;O43353 O43353-2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 1 T(0.95)T(0.05)PCSSAIINPLSTAGNSER 180.76 3.1907e-12 0.0 7065.1 9046.3 7586.2 9430.2 9955.3 7600.1 7095.1 7565.9 5496.6 5704.4 True False 6672.450025836167 9740.122121560882 7098.112151230039 8145.79049199763 8704.62621248879 8646.94478816131 7425.0362086739315 7587.9155163978285 6596.07358783598 5539.699150188855 1.2044787713081304 1.7582402685584162 1.2813172626871001 1.4704391468117777 1.57131749874757 1.5609051238579492 1.340332030200738 1.3697342239495347 1.1906916619490269 1.0 12.435591913226055 -8.358075121349577 1.1100972096498674 1.0022488172953714 1.4776478117378025 0.5046292998609823 0.14809813048271517 0.36754593088986615 0.9598377031821642 0.13196058790862036 0.04320822249446811 4.3845485023316005e-09 8.358075121349577 0.47539899444243106 T(ph)TPDQELVPASEPVWERPWSVEEIR ddPTM_A459_Selumetinib_30min_R1 1 TTPDQELVPASEPVWERPWSVEEIR 25 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 T(0.511)T(0.488)PDQELVPAS(0.002)EPVWERPWSVEEIR 72.76899999999998 0.00087105 37390000.0 161.62 370.69 356.62 250.13 309.96 276.52 537.95 481.36 148.76 398.05 True False 165.38543154222435 327.28944247089424 308.1929627734403 206.4494910216147 281.9241727278828 273.7384598600716 497.37199839397044 468.5927691223596 252.4348549994776 449.14359483533804 0.3682239565341165 0.7286966712525041 0.6861791336163391 0.45965141971422707 0.6276927378453208 0.6094675800963559 1.1073785847403959 1.0433027978371858 0.5620359677889285 1.0 8.811032949746444 -7.184820286918744 7.922009718491839 0.9312878200817946 0.5871337425837085 0.5088282000441818 0.16753061774436254 0.26455643201798107 24.829524583214628 0.06359489198305353 0.04918424042554804 6.534008770418875e-08 7.184820286918744 -0.344154077498086 T(ph)TPDQELVPASEPVWERPWSVEEIR ddPTM_A459_Selumetinib_30min_R2 1 TTPDQELVPASEPVWERPWSVEEIR 25 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 T(0.645)T(0.353)PDQELVPAS(0.002)EPVWERPWSVEEIR 61.526 0.0076861 8376400.0 959.6 412.47 1174.4 1042.3 0.0 673.38 645.75 794.56 538.52 621.82 True False 906.2692735831604 444.1051226999127 1098.840382590039 900.3369419322113 0.0 766.1319826649731 675.7786545293499 796.8720380535104 646.2390475059913 603.8664409176132 1.500777675616527 0.7354360047315545 1.8196745308785196 1.4909537621665023 0.0 1.2687109777135275 1.1190862891841804 1.3196163655701962 1.0701688382020207 1.0 9.23808568910548 T(ph)TPDQELVPASEPVWERPWSVEEIRR ddPTM_A459_Selumetinib_30min_R1 2 TTPDQELVPASEPVWERPWSVEEIRR 26 2 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 T(0.793)T(0.207)PDQELVPASEPVWERPWSVEEIRR;T(0.5)T(0.5)PDQELVPASEPVWERPWSVEEIRR 67.367 0.0017072 20435700.0 1511.6599999999999 1509.52 1958.5 1524.69 1434.98 1611.0300000000002 1692.4299999999998 1171.51 824.94 1125.64 True False 1546.878736821673 1332.7846966431907 1692.546457270437 1258.4315134759754 1305.1863123662968 1594.8245008982042 1564.7686425167894 1140.4377491992184 1399.862928766262 1270.1268586621024 1.2178930996318662 1.0493319525949474 1.3325806361210986 0.9907919865591643 1.0276031118191804 1.2556418990919729 1.2319782326035134 0.8978927903315949 1.102144182858095 1.0 10.310756883409594 -7.75617782672017 24.999987793126294 1.0000138636906217 1.1528235489926977 0.29153008079985976 0.11264457644176033 168.90551737890115 802557.3483509041 0.05476575507250668 0.03042190520827027 1.7531625029121142e-08 7.75617782672017 0.15280968530207595 T(ph)TPDQELVPASEPVWERPWSVEEIRR ddPTM_A459_Selumetinib_30min_R2 1 TTPDQELVPASEPVWERPWSVEEIRR 26 2 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 T(0.5)T(0.5)PDQELVPASEPVWERPWSVEEIRR 53.615 0.018008 12353000.0 21603.0 19845.0 21768.0 22786.0 17681.0 14895.0 15887.0 13731.0 10171.0 18464.0 True False 20402.391743660908 21367.047688267667 20367.470579206387 19682.507491957553 15459.75470985448 16946.651046652383 16625.776979493272 13770.954936710581 12205.484201484509 17930.896344766676 1.1378344591019602 1.1916329935454604 1.1358869176191992 1.0976867588497383 0.8621852701951832 0.9451089739637274 0.9272139362037907 0.7680014803459495 0.6806957090601223 1.0 14.130159988214615 -6.265395407104698 1.005184782013238 0.8278286893738939 1.184020061611223 0.6967415095018192 0.08885956912098408 0.3008901276430055 0.6412704153388993 0.041669025702185565 0.06452268939926308 5.427559496990184e-07 6.265395407104698 0.3561913722373292 T(ph)TPESPPYSSGSYDSIK ddPTM_A459_Selumetinib_30min_R2 1 TTPESPPYSSGSYDSIK 17 0 A0A087WTU5;A0A087X0N3;Q96MY1-2;Q96MY1 A0A087WTU5 NOL4L Nucleolar protein 4-like 1 T(0.73)T(0.003)PES(0.267)PPYSSGSYDSIK 199.65 1.3974e-07 60608000.0 28979.0 24341.0 26415.0 31347.0 22997.0 23579.0 22600.0 18794.0 19643.0 24764.0 True False 27368.463192128373 26207.876431349123 24715.487658477447 27077.484523408806 20107.9112642115 26826.79322114913 23650.944781050435 18848.687428485806 23572.14887127718 24048.998975400886 1.1380292052955254 1.089769950847289 1.0277137806757901 1.125929796541872 0.8361225880869043 1.1155056078878618 0.9834482011181583 0.783761829245602 0.9801717275379543 1.0 14.553689223512295 -5.8541661560166105 0.5853762158133586 0.9287000734943321 1.1526681625671442 0.30903829359514146 0.09503569664045275 1.6505009294000113 0.9622781235991159 0.06245112107002973 0.217048961986429 1.3990519591628956e-06 5.8541661560166105 0.22396808907281207 T(ph)TPLKPSPLPVIPDTIK ddPTM_A459_Selumetinib_30min_R2 1 TTPLKPSPLPVIPDTIK 17 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 T(0.5)T(0.5)PLKPSPLPVIPDTIK 73.208 0.035498 3333200.0 34651.0 31795.0 34564.0 34761.0 32035.0 28593.0 30409.0 30056.0 17547.0 30767.0 True False 32725.2361389434 34233.574262961476 32340.18987043776 30026.491833930333 28010.476903466337 32531.42620858888 31823.07875429038 30143.45798396134 21056.890304144017 29878.676767733763 1.0952705969323133 1.1457526894206576 1.0823836049313338 1.0049471757851136 0.9374738085360959 1.088784033559339 1.0650765762376866 1.0088618789341273 0.7047464139002143 1.0 14.866828636682621 -6.381131035900152 0.4054498047927244 0.9127423138505273 1.1515530940405239 0.3158853763850281 0.09738710445874763 2.309269939353692 0.699399731004931 0.10041230206474958 0.23363436308214158 4.157851403291038e-07 6.381131035900152 0.23881078018999657 T(ph)TPNSGDVQVTEDAVR ddPTM_A459_Selumetinib_30min_R1 2 TTPNSGDVQVTEDAVR 16 0 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 T(0.985)T(0.015)PNSGDVQVTEDAVR;T(0.646)T(0.354)PNSGDVQVTEDAVR 232.01 4.724800000000001e-15 28577000.0 6240.1 8548.0 6406.799999999999 5865.8 6668.6 5694.0 7410.6 6858.6 3509.5 6401.5 True False 6385.482188879061 7547.1961861426125 5536.79175003331 4841.448144703107 6065.426307436955 5636.723529738352 6851.61247569171 6676.687648127427 5955.365176261537 7223.194880890381 0.8840246309527706 1.0448556782137233 0.766529470869102 0.670264090134353 0.8397151686276099 0.7803643156092628 0.9485570566313078 0.9243399573492349 0.8244779871600859 1.0 12.81842137929719 -11.09115876673112 8.53302638277974 1.0000303054404855 0.8536473765905632 0.1627512070835182 0.099560537617065 6.194204634196877e-05 3.133931623192155e-06 0.10402646126693185 0.025224908334498232 8.106646458339617e-12 11.09115876673112 -0.14638292884992232 T(ph)TPNSGDVQVTEDAVR ddPTM_A459_Selumetinib_30min_R2 4 TTPNSGDVQVTEDAVR 16 0 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 T(0.619)T(0.381)PNSGDVQVTEDAVR;T(0.5)T(0.5)PNS(0.001)GDVQVTEDAVR;T(0.991)T(0.009)PNSGDVQVTEDAVR;T(0.988)T(0.012)PNSGDVQVTEDAVR 234.12 2.3241e-15 76828000.0 170454.0 132045.0 157507.0 178060.0 188026.0 136853.0 173871.0 159965.0 135348.0 148738.0 True False 160980.84906142566 142172.42690840544 147373.1711006552 153807.92082936733 164404.4929062328 155703.25852215642 181956.34601885045 160430.4716663687 162421.38193909434 144443.5474722653 1.1144897219610015 0.9842767599965244 1.020282135683163 1.0648306796736635 1.1381920188425185 1.0779523297989695 1.259705602659669 1.1106793932568921 1.1244627038136197 1.0 17.140146232249442 -6.116418899303945 3.326512352980418 1.129259767405777 1.0345936459465988 0.20962054436643018 0.06785337405501222 0.3270497693455606 6.756622239097214 0.020233984825734592 0.0274269159553624 7.648585057397962e-07 6.116418899303945 -0.09466612145917819 T(ph)TPNSGDVQVTEDAVRR ddPTM_A459_Selumetinib_30min_R1 1 TTPNSGDVQVTEDAVRR 17 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 T(0.498)T(0.498)PNS(0.004)GDVQVTEDAVRR 87.963 0.012905000000000002 4403800.0 1323.1 1202.7 1952.5 2009.9 1706.8 1336.9 1587.8 1586.7 866.31 926.4 True False 1353.9256556955631 1061.8873248799396 1687.361224314795 1658.9086954957168 1552.420241360015 1323.4519998080787 1468.030967654886 1544.6155616720303 1470.0647972210097 1045.3124639001555 1.2952353506280254 1.0158563697958232 1.6142170715339004 1.5869979099896867 1.485125543770706 1.266082674332763 1.404394397228872 1.4776591832732289 1.4063400638466175 1.0 10.029718540592743 -10.461355338812897 6.821351859482041 0.9999999771952645 1.3972370247977617 0.34126023648332826 0.164460558207926 6.10144780926804e-08 9.283032436296394e-09 0.1699809197580989 0.041226426160500096 3.456564467323208e-11 10.461355338812897 0.39723704760249723 T(ph)TPPEAAQNGQSPMAALILVADNAGGSHASK ddPTM_A459_Selumetinib_30min_R1 2 TTPPEAAQNGQSPMAALILVADNAGGSHASK 31 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 T(0.5)T(0.5)PPEAAQNGQSPMAALILVADNAGGSHASK;T(0.5)T(0.5)PPEAAQNGQS(0.001)PMAALILVADNAGGSHASK 104.65 7.6664e-11 23466000.0 2192.56 2737.93 2264.69 2311.01 2747.21 2283.5699999999997 2956.12 2789.5 1189.51 2351.55 True False 2243.64238202091 2417.371882770875 1957.1575370517148 1907.4354865304524 2498.7253405593206 2260.5993591156657 2733.1374884141333 2715.5133984270037 2018.5115916269745 2653.394348536713 0.8455744180122446 0.9110488548767735 0.7376052255975607 0.7188661902375574 0.941709000751174 0.8519650915674616 1.0300532560949325 1.023411163864334 0.7607280812745146 1.0 11.373623390081427 -6.287774181583095 24.517000115017588 0.9364514851414013 0.8062812959332448 0.3318469374317031 0.09126006595232002 731.7881560685256 681272.9895025718 0.029082945022431275 0.03298791045052863 5.15496615683154e-07 6.287774181583095 -0.13017018920815648 T(ph)TPSYVAFTDTER ddPTM_A459_Selumetinib_30min_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 1 T(0.964)T(0.012)PS(0.024)YVAFTDTER 225.33 3.5397e-09 12404000.0 1287.1 2025.6 1852.8 2058.4 1968.5 1595.9 1966.6 1801.4 663.64 1414.1 True False 1317.0869257393692 1788.4418103241069 1601.1999367018964 1698.9390809534705 1790.4495225669016 1579.8466949612623 1818.257778681256 1753.6210202281434 1126.1486096521467 1595.6135095004427 0.8254423254110734 1.1208490023903315 1.003501115507102 1.0647560144344586 1.1221072721598218 0.9901186506348165 1.1395352119138922 1.0990261800786394 0.7057778108213205 1.0 10.639895528044866 -8.242283403924967 24.950972444571008 0.8528888674444572 1.051229158337813 0.32965183550785393 0.10973224014951422 718.9421680904037 936437.4683169881 0.06927626090509431 0.026096955707637357 5.724223681933251e-09 8.242283403924967 0.1983402908933558 T(ph)TPTLGLEEVLSSR ddPTM_A459_Selumetinib_30min_R2 1 TTPTLGLEEVLSSR 14 0 O43474-4;O43474-1;O43474 O43474-4 KLF4 Krueppel-like factor 4 1 T(0.996)T(0.004)PTLGLEEVLSSR 116.9 0.0060408 1025300.0 7441.4 5258.2 6393.7 5900.2 4894.4 4077.8 5614.1 4217.4 3438.4 4408.2 True False 7027.836778284418 5661.487032222174 5982.336302934208 5096.582581587289 4279.521715508837 4639.479935417191 5875.166774128108 4229.671935771847 4126.176076923049 4280.923812120908 1.6416635956907162 1.3224918920987034 1.3974404977719903 1.1905333533750222 0.9996724780272656 1.0837567167818019 1.3724062917198614 0.9880278466521762 0.9638517894759747 1.0 12.06370644468806 -1.522878745280338 0.3633003405839021 1.0321249899753187 8.557542768132183 0.6925420806003781 0.1205994621318588 39.75483864397831 0.5531294706000996 0.10320521955415164 207.51169712873485 0.029999999999999964 1.522878745280338 7.525417778156864 T(ph)TPTMSEEPPLDLTGK ddPTM_A459_Selumetinib_30min_R1 2 TTPTMSEEPPLDLTGK 16 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.579)T(0.406)PT(0.013)MS(0.001)EEPPLDLTGK;T(0.858)T(0.142)PTMSEEPPLDLTGK 209.53 1.2546e-07 89085000.0 6629.3 8632.8 9146.7 10126.3 7502.8 7183.9 7527.6 7613.2 4254.7 6364.2 True False 6783.749791627695 7622.067762720162 7904.628379226708 8357.931799193126 6824.173064726923 7111.6364884593095 6959.787071494471 7411.27320484118 7219.915149006977 7181.107062557607 0.9446662934463492 1.0614056713430344 1.1007534507376378 1.1638778988230798 0.9502954078359669 0.9903259241934272 0.969180240715655 1.0320516238343893 1.0054041927116943 1.0 12.809990556362825 -6.290198540700951 24.988199372526218 0.9916665001312568 1.0695906914633935 0.3210545095369929 0.05444486334059529 894.7243833812581 777403.6035449064 0.01771546128403794 0.02009100803444466 5.126269794761824e-07 6.290198540700951 0.07792419133213668 T(ph)TPTMSEEPPLDLTGK ddPTM_A459_Selumetinib_30min_R2 2 TTPTMSEEPPLDLTGK 16 0 O60292 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.843)T(0.157)PTMSEEPPLDLTGK;T(0.99)T(0.01)PTMSEEPPLDLTGK 246.96 7.431899999999998e-29 26742000.0 149393.0 130454.0 146073.0 142436.0 148971.0 103884.0 127136.0 130044.0 93486.0 139011.0 True False 141090.33512756252 140459.40232427654 136674.82221225736 123035.97108419491 130255.93116236242 118193.07803494038 133048.07591520468 130422.4065100569 112185.81221708596 134997.39123604668 1.0451337898882962 1.0404601232528958 1.0124256547541548 0.911395175548712 0.9648773948128103 0.8755212004673224 0.9855603482186291 0.9661105693665569 0.8310220752408908 1.0 17.042572002548596 -5.632792228999842 4.2964545306610225 0.9332733417998648 1.039562064825221 0.47132866653010497 0.04867388840578738 0.18036299952170892 5.860700537849894 0.01297339847523756 0.023362146973896873 2.3292053072179974e-06 5.632792228999842 0.1062887230253563 T(ph)TPTQPSEQK ddPTM_A459_Selumetinib_30min_R1 2 TTPTQPSEQK 10 0 O95104-2;O95104-3;O95104 O95104-2 SCAF4 Splicing factor, arginine/serine-rich 15 1 T(0.998)T(0.002)PTQPSEQK;T(0.987)T(0.013)PTQPSEQK 141.91 0.0029396 97075000.0 14273.7 16467.0 15306.4 15247.3 13862.800000000001 13625.5 14676.900000000001 15242.8 9002.7 15290.7 True False 14606.249438214629 14539.035984699396 13227.874952036866 12584.645282268679 12608.91218767613 13488.43984096416 13569.809616560022 14838.511428407644 15276.924368807453 17253.410289030773 0.8465717324012672 0.8426760704776667 0.7666817591677381 0.7294004530959098 0.7308069521590475 0.7817839844415991 0.7865001405077187 0.8600335342307107 0.8854437536050531 1.0 14.074593931051805 -8.406153066194184 1.12247868090587 0.9964173030311743 0.7794548937664016 0.7561150277709444 0.03857248050015071 0.25820444874637466 0.7015818495891601 0.041497876560485536 0.013444274131996605 3.9250657288638014e-09 8.406153066194184 -0.21696240926477262 T(ph)TPTQPSEQK ddPTM_A459_Selumetinib_30min_R2 3 TTPTQPSEQK 10 0 O95104-2;O95104-3;O95104 O95104-2 SCAF4 Splicing factor, arginine/serine-rich 15 1 T(0.998)T(0.002)PTQPSEQK;T(0.999)T(0.001)PTQPSEQK;T(0.993)T(0.007)PTQPSEQK 179.94 0.00027112 127313000.0 443828.0 415664.0 447056.0 432414.0 408379.0 306117.0 372372.0 371750.0 281985.0 359107.0 True False 419161.8165442544 447544.0922295829 418292.9036777694 373518.4672442426 357074.7790654187 348281.83809654805 389688.03584111953 372831.7309534746 338389.87931920326 348738.6478379626 1.2019368060950133 1.2833223246238228 1.1994452185641449 1.0710555585390515 1.0239036633282164 0.9986901086408214 1.117421422194031 1.0690863581219898 0.9703251458279216 1.0 18.41178672944477 -5.746331306625149 2.927669469090321 1.0366775479214843 1.2433701372006636 0.8128472163917108 0.04292115565221491 0.10499806142783008 1.8408868904650602 0.01262168711938958 0.02248977293099244 1.7933650153905899e-06 5.746331306625149 0.20669258927917933 T(ph)TPVDLCLLEESVGSLEGSR ddPTM_A459_Selumetinib_30min_R1 1 TTPVDLCLLEESVGSLEGSR 20 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 T(0.811)T(0.188)PVDLCLLEES(0.001)VGSLEGSR 102.5 0.0030347 0.0 462.39 480.89 474.7 362.3 745.53 336.21 418.06 363.76 193.5 267.42 True False 473.1627873456821 424.58717524030413 410.23834734045244 299.03110621329307 678.0969431340119 332.8280326542556 386.5253976179628 354.1119031409956 328.3553673191645 301.74596189138583 1.5680832458530072 1.407101432539254 1.359548756739017 0.9910028433816457 2.247244466449876 1.1030074124871232 1.2809629504075801 1.1735431384777206 1.0881847937947113 1.0 8.237190654049956 T(ph)TPVDLCLLEESVGSLEGSR ddPTM_A459_Selumetinib_30min_R2 2 TTPVDLCLLEESVGSLEGSR 20 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 T(0.79)T(0.21)PVDLCLLEESVGSLEGSR;T(0.818)T(0.182)PVDLCLLEESVGSLEGSR 228.32 1.8694000000000004e-23 209750000.0 325320.0 295060.0 280380.0 330290.0 293570.0 194834.0 264379.0 235840.0 190949.0 248480.0 True False 307240.0167591428 317690.1532325658 262340.65605466196 285303.93221797014 256689.11205090082 221670.61497304266 276673.14735704975 236526.2553545862 229144.1355608366 241305.73677142704 1.2732395875452018 1.3165462101445713 1.0871712358134276 1.1823338145011433 1.06375055763405 0.9186296933463152 1.146566803834937 0.9801932540817787 0.9496008616566365 1.0 17.880502688843798 -5.425635068522593 0.6305084945611574 0.9931653079668963 1.388104193814991 0.6889828437753907 0.07196718481470583 1.0186365528724455 0.5232657176255506 0.03902557984277225 0.2613924084050518 3.752882191446868e-06 5.425635068522593 0.39493888584809467 T(ph)TRTPEEGGYSYDISEK ddPTM_A459_Selumetinib_30min_R1 1 TTRTPEEGGYSYDISEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.422)T(0.422)RT(0.157)PEEGGYSYDISEK 124.82 0.0017908000000000004 640180000.0 1418.3 1730.0 2298.9 2302.7 1697.7 1610.1 1626.5 1601.1 802.29 1315.4 True False 1451.3436304686104 1527.45079574482 1986.7220069537955 1900.5766720324327 1544.1433347532795 1593.9038558538318 1503.8117954973372 1558.633626894238 1361.4275330568082 1484.2444030810295 0.9778333187282883 1.029110025662958 1.3385410130768969 1.2805011547203216 1.0403565151048644 1.0738823421164119 1.0131834032021203 1.0501192550625689 0.9172529337019731 1.0 10.535512957537934 -6.450188303402261 10.178459019805555 1.0188914471897603 1.1606081710190086 0.3003472304206355 0.10557122771002944 0.8451267618006104 115.26398486638409 0.03593315671959314 0.04071750868547177 3.5465958095650405e-07 6.450188303402261 0.14171672382924827 T(ph)TRTPEEGGYSYDISEK ddPTM_A459_Selumetinib_30min_R2 3 TTRTPEEGGYSYDISEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.495)T(0.495)RT(0.009)PEEGGYSYDISEK;T(0.491)T(0.491)RT(0.019)PEEGGYSYDISEK;T(0.333)T(0.333)RT(0.333)PEEGGYSYDISEK 124.82 0.0017908000000000004 557026000.0 221488.0 195777.0 235420.0 243838.0 224773.0 161510.0 160041.0 137837.0 125590.0 223309.0 True False 209178.5836467142 210792.46637772588 220273.33350591586 210626.84375598835 196535.0062438847 183756.53645819574 167483.2236152253 138238.08284985618 150711.50927779387 216861.48894353924 0.9645722929679538 0.9720142908020268 1.015732828262859 0.9712505654280825 0.9062697448095701 0.8473451757312129 0.7723050525528312 0.6374487398537 0.6949666813227139 1.0 17.726414351130117 -6.829178960669947 1.5911887959867812 0.7457981598857502 0.9821881628334916 0.49661169277710004 0.09062703178468211 0.27460111376691093 1.4388770010908523 0.039648516513493506 0.03411796833148875 1.4819073065513536e-07 6.829178960669947 0.23639000294774148 T(ph)TSGDDACNLTSFR ddPTM_A459_Selumetinib_30min_R2 2 TTSGDDACNLTSFR 14 0 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7;A0A0U1RQT6 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 T(0.886)T(0.102)S(0.012)GDDACNLTSFR;T(0.881)T(0.106)S(0.013)GDDACNLTSFR 157.37 0.00073385 19132800.0 66082.0 38824.0 66696.0 63597.0 75775.0 37648.0 76775.0 94258.0 65006.0 51277.0 True False 62409.42698720552 41801.67596116421 62404.85197311412 54934.97888905576 66255.46706290508 42833.67026548298 80345.18962677642 94532.27517474805 78009.01641939845 49796.49977635403 1.253289433343682 0.8394500848233076 1.253197559133407 1.1031895642420584 1.330524582259226 0.8601743186339903 1.6134706251970043 1.8983718855604566 1.5665562192072222 1.0 15.603756717570377 -7.280141845813106 24.290454169794543 1.5944641013020837 1.1111744781072457 0.36519560021242825 0.25928137945381746 520.4013527057111 675885.2584640116 0.1027940400187725 0.06945601350767167 5.2463607979581066e-08 7.280141845813106 -0.48328962319483804 T(ph)TSPPEVSGYSYEK ddPTM_A459_Selumetinib_30min_R1 1 TTSPPEVSGYSYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.832)T(0.149)S(0.019)PPEVSGYSYEK 137.93 0.0013206 0.0 1626.3 2053.0 1869.0 2028.5 1800.7 2033.4 1826.0 1809.9 1045.3 1437.4 True False 1664.1896257710644 1812.633805586194 1615.2000656821274 1674.2605546609593 1637.8270029394073 2012.9458421794807 1688.2633498789658 1761.8955726162524 1773.7977543086438 1621.9042914616628 1.0260714115697258 1.117596035184447 0.9958664479680898 1.0322807353522154 1.0098172941286165 1.2411002626828311 1.0409142874623631 1.0863129112436278 1.0936513107749992 1.0 10.663472973324827 T(ph)TSPPEVSGYSYEK ddPTM_A459_Selumetinib_30min_R2 1 TTSPPEVSGYSYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.978)T(0.011)S(0.011)PPEVSGYSYEK 239.38 4.1549999999999998e-19 1001700000.0 65371.0 79677.0 69833.0 87347.0 91731.0 61854.0 66445.0 70218.0 54308.0 76675.0 True False 61737.94152084693 85787.96969806521 65340.02080842146 75450.18791802038 80206.93169445508 70373.82704529267 69534.82415826975 70422.32275478436 65171.117492303674 74461.19352442522 0.8291290885714216 1.1521165003878766 0.8775043444205366 1.0132820110286138 1.0771641965172785 0.9451074272964508 0.933839774344478 0.9457587156682358 0.8752360042540258 1.0 16.18420112061088 -6.972103874643011 24.96538150658984 0.9349434624593 0.9956381581681406 0.06915523884597508 0.09002203160214682 506.8010802214031 453555.5117310224 0.02984645142667865 0.026321632520005182 1.0663410430578639e-07 6.972103874643011 0.06069469570884056 T(ph)TSPPLSIPTTHLIHQPAGSR ddPTM_A459_Selumetinib_30min_R1 2 TTSPPLSIPTTHLIHQPAGSR 21 0 Q5T5U3;A0A087WW76;A0A452Q6Z5;E7ESW5;A0A1B0GV73;Q5T5U3-3 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 T(0.332)T(0.332)S(0.332)PPLS(0.003)IPTTHLIHQPAGSR;T(0.367)T(0.367)S(0.266)PPLSIPTTHLIHQPAGSR 156.7 2.4038e-07 88573000.0 4183.3 4696.6 5077.4 5469.3 5868.799999999999 4351.1 5048.6 4734.9 1906.3600000000001 3754.75 True False 4280.762750715178 4146.719888609896 4387.916968161814 4514.189426476302 5337.968076220796 4307.331884482707 4667.78003734882 4609.315070877223 3234.953684974485 4236.708736862165 1.0103981690952022 0.9787597274579424 1.0356900227726389 1.0654943983285592 1.2599327467986996 1.0166693421726336 1.1017467395707545 1.0879471205497646 0.7635534765060082 1.0 12.048728235094313 -8.240592455711601 24.883372912757313 0.8817767300149261 1.0709402696852268 0.4096890942424941 0.0901610156180217 637.1461610983429 760515.1968649572 0.061452001181510583 0.02317108403706383 5.746554690614478e-09 8.240592455711601 0.18916353967030075 T(ph)TSPPLSIPTTHLIHQPAGSR ddPTM_A459_Selumetinib_30min_R2 4 TTSPPLSIPTTHLIHQPAGSR 21 0 Q5T5U3;A0A087WW76;A0A452Q6Z5;E7ESW5;A0A1B0GV73;Q5T5U3-3 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 T(0.333)T(0.333)S(0.296)PPLS(0.037)IPTT(0.001)HLIHQPAGSR;T(0.328)T(0.328)S(0.328)PPLS(0.016)IPTTHLIHQPAGSR;T(0.332)T(0.332)S(0.332)PPLS(0.004)IPTTHLIHQPAGSR;T(0.33)T(0.33)S(0.33)PPLS(0.011)IPTTHLIHQPAGSR 87.72 0.00091038 55497300.0 62697.8 54545.5 73037.5 73290.4 68528.6 52997.7 57844.100000000006 52452.799999999996 45455.0 65712.5 True False 59213.30727517947 58728.964458574126 68338.34676721724 63308.121087008076 59919.424614542964 60297.65210977971 60533.96526590973 52605.42896397148 54547.270118816064 63815.209383420755 0.9278870640290202 0.9202972931689849 1.0708786733993165 0.9920538018865387 0.9389520961144112 0.9448790138334183 0.9485820990134759 0.8243399884172191 0.8547691161064731 1.0 15.961612688915734 -7.600412945276401 7.281156939001975 0.8799146584000321 0.9667457692921877 0.22629864342466377 0.05878393144714265 0.2908943243842813 22.96995391920021 0.02831210360541725 0.01623798012439382 2.5094991604396493e-08 7.600412945276401 0.08683111089215556 T(ph)TSPSSDTDLLDR ddPTM_A459_Selumetinib_30min_R1 1 TTSPSSDTDLLDR 13 0 Q96QT6;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7ERZ4;K7EJ43;K7ENU0 Q96QT6;K7ENU0 PHF12 PHD finger protein 12 1 T(0.598)T(0.09)S(0.311)PSSDTDLLDR 217.46 4.2937e-08 25484000.0 2803.3 2652.7 3317.9 3036.4 2940.2 2924.8 3044.5 2610.0 1461.0 2419.7 True False 2868.611435727739 2342.1206507932256 2867.3474039201346 2506.149740287176 2674.259429134472 2895.379167505922 2814.850913858989 2540.774321525176 2479.210292781908 2730.292064873926 1.050661016318853 0.8578278789018037 1.0501980505343986 0.9179053671691714 0.9794774205806289 1.0604649974103115 1.0309706240123315 0.9305870072337844 0.9080384932724727 1.0 11.41483957207371 -4.458406649335189 22.936568940588824 0.9730735728721809 3.387143280633925 0.12480153029665997 0.06329559791123719 950.0721690364446 421441.68677524163 0.015288616371535791 28942.937214205813 3.480113038914343e-05 4.458406649335189 2.414069707761744 T(ph)TSPSSDTDLLDR ddPTM_A459_Selumetinib_30min_R2 2 TTSPSSDTDLLDR 13 0 Q96QT6;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7ERZ4;K7EJ43;K7ENU0 Q96QT6;K7ENU0 PHF12 PHD finger protein 12 1 T(0.447)T(0.447)S(0.106)PSSDTDLLDR;T(0.987)T(0.01)S(0.003)PSSDTDLLDR 222.73 1.6584e-08 22442500.0 58541.0 52920.0 55365.0 57699.0 60387.0 45780.0 39951.0 42390.0 45428.0 48935.0 True False 55287.52557819069 56978.79383538045 51802.87617685417 49840.296663673245 52800.64519337041 52085.779450536786 41808.800661404675 42513.34788195772 54514.86936437308 47522.11940160082 1.163406141695109 1.198995216393086 1.0900792479198465 1.0487810158987634 1.1110751342372112 1.096032334129909 0.8797755905641765 0.8946012597351797 1.1471472663851079 1.0 15.536311558743584 -5.97548734758109 0.6565426581007346 0.983451927665967 1.1979750310040627 0.3900759861733758 0.0803658377722581 1.0787463223379474 0.8797154256149351 0.050952590392243875 0.14152291015695806 1.0580657404633544e-06 5.97548734758109 0.21452310333809566 T(ph)TTPPDSGVLFEGLGISTRPR ddPTM_A459_Selumetinib_30min_R1 1 TTTPPDSGVLFEGLGISTRPR 21 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 T(0.518)T(0.141)T(0.334)PPDS(0.008)GVLFEGLGISTRPR 93.388 0.00071981 23778000.0 1557.9 2128.4 1888.3 2139.6 1518.2 1693.6 1705.2 1771.8 1149.8 1521.9 True False 1594.1960388542955 1879.2059385336847 1631.8792316894387 1765.959025266249 1380.879078059981 1676.5639216657653 1576.5753911356044 1724.8061083824928 1951.1266219306212 1717.2506895613644 0.9283420577699691 1.09431077824385 0.9502859667543753 1.0283641380964164 0.8041220111040966 0.9763070306840338 0.9180810936452775 1.004399718030137 1.136192073638937 1.0 10.745884948455803 -8.009520140204046 16.81256417259149 1.068831324909531 0.9598319403534845 0.24778819355418413 0.07707095692147348 8.248656080175511 14557.708489505721 0.04581123133009027 0.01984551018418175 9.783175847108861e-09 8.009520140204046 -0.10899938455604641 T(ph)TTPPDSGVLFEGLGISTRPR ddPTM_A459_Selumetinib_30min_R2 1 TTTPPDSGVLFEGLGISTRPR 21 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 T(0.619)T(0.187)T(0.187)PPDS(0.008)GVLFEGLGISTRPR 58.51600000000001 0.03438 2682000.0 10069.0 10795.0 13453.0 10060.0 11940.0 9156.5 9753.5 9631.0 7785.7 10282.0 True False 9509.40528940062 11622.94178860416 12587.4486265189 8689.81064553204 10439.990455045674 10417.724760568808 10207.057076193603 9659.024615502116 9343.05755063396 9985.131944155712 0.952356497899506 1.164024857518989 1.2606191582562234 0.8702749942746804 1.0455535804067357 1.0433236955537972 1.0222255582879687 0.9673407091185744 0.9356969545207103 1.0 13.28556577631946 -5.7645522302084835 24.999946932965504 0.9888204305287341 1.1295026260293184 0.3615587791257615 0.08633122330517189 88.55677260649654 711227.8329878824 0.024379158476393128 0.037974530652182134 1.7196805122853623e-06 5.7645522302084835 0.14068219550058425 T(ph)VASDLQK ddPTM_A459_Selumetinib_30min_R1 1 TVASDLQK 8 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 T(0.612)VAS(0.388)DLQK 119.22 0.018668 65223000.0 7866.3 9967.7 9635.7 10675.0 8814.9 8900.7 9259.1 7924.9 4982.6 7790.1 True False 8049.569484844692 8800.677050141994 8327.224865111431 8810.811644567779 8017.5938513969995 8811.167039188997 8560.678632455827 7714.7059082968835 8455.108285294415 8790.035216999788 0.9157607775310107 1.0012106701372054 0.9473482937823402 1.002363634166995 0.9121230636131128 1.0024040657025288 0.9739072052748562 0.877664960133125 0.961896974990768 1.0 13.101653230154676 T(ph)VASDLQK ddPTM_A459_Selumetinib_30min_R2 3 TVASDLQK 8 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 T(0.991)VAS(0.009)DLQK;T(0.874)VAS(0.126)DLQK;T(0.755)VAS(0.245)DLQK 154.85 0.0015426 142017000.0 511580.0 443540.0 523440.0 512430.0 493580.0 352611.0 425850.0 437160.0 329827.0 468190.0 True False 483148.4316169993 477558.091794116 489762.4402783816 442636.1500089448 431572.06773881393 401179.96456603863 445652.86880576704 438432.06322426646 395801.61613637215 454672.138196291 1.0626303901832985 1.0503350693284503 1.0771771549963358 0.9735282037841738 0.9491940048292462 0.8823500075406892 0.9801631359548357 0.9642817898707192 0.8705209378048512 1.0 18.794467074477915 -5.8958374739685535 3.46077284132701 0.939428577860342 1.0623781633816585 0.6704881772785027 0.03823539342620224 0.13654652943467338 3.1974763075879813 0.010977271028346653 0.017147732390726516 1.2710496811596764e-06 5.8958374739685535 0.12294958552131652 T(ph)VFSPTLPAAR ddPTM_A459_Selumetinib_30min_R2 2 TVFSPTLPAAR 11 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 T(0.957)VFS(0.034)PT(0.009)LPAAR;T(0.988)VFS(0.003)PT(0.009)LPAAR 196.16 4.7966e-05 262758000.0 268530.0 267829.0 314660.0 313110.0 321030.0 227044.0 262498.0 315328.0 191884.0 233666.0 True False 253606.17761076038 288370.62309403066 294415.1181759038 270463.87785512337 280699.34135538625 258317.25009977477 274704.6771299195 316245.55227463925 230266.16168691893 226919.45544282137 1.1176043813249124 1.2708060775630303 1.2974432606554964 1.191893737481995 1.236999889708074 1.1383653710770734 1.2105823037246755 1.3936467089501106 1.0147484323790863 1.0 17.791820781409136 -8.368480168817864 8.673143842341343 1.0022575949597232 1.2304821964338273 0.5911131222488462 0.07479684352058982 0.24011452069499398 17.610535428807747 0.07105839520308123 0.018364011728963802 4.280749663204122e-09 8.368480168817864 0.22822460147410406 T(ph)VGTPIASVPGSTNTGTVPGSEK ddPTM_A459_Selumetinib_30min_R2 2 TVGTPIASVPGSTNTGTVPGSEK 23 0 A0A087WW66;Q99460-2;Q99460;H7BZR6 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 T(0.974)VGT(0.025)PIAS(0.001)VPGSTNTGTVPGSEK;T(0.499)VGT(0.499)PIAS(0.002)VPGSTNTGTVPGSEK 75.512 0.0012293 9886800.0 105579.0 76426.0 102734.0 118187.0 117010.0 98154.0 118914.0 122156.0 107260.0 98284.0 True False 99711.3418462238 82287.6284516779 96124.2062883219 102089.72671605324 102310.15771732776 111673.82254670134 124443.73662362067 122511.45373598565 128714.99709480174 95446.28554750023 1.0446854089109734 0.8621354721103973 1.0071026414169286 1.0696039780955835 1.0719134550962868 1.1700174805768135 1.3038091101165947 1.2835643947088549 1.3485595207447318 1.0 16.542401433370664 -6.5339980390269625 1.1850432530332635 1.2576558958300121 0.9652360226722819 0.5318500457308777 0.10132284697192002 0.31852602990667095 0.9407480899665084 0.04493752808088642 0.0504321208151224 2.924165581319675e-07 6.5339980390269625 -0.2924198731577302 T(ph)VHPNSPGIPYR ddPTM_A459_Selumetinib_30min_R2 1 TVHPNSPGIPYR 12 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;F8VWY3;C9J102;C9JNI4 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.999)VHPNS(0.001)PGIPYR 84.507 0.044106 5467500.0 29731.0 30360.0 30464.0 34820.0 42867.0 29081.0 30113.0 29522.0 28080.0 37103.0 True False 28078.67004262288 32688.514377213713 28503.97940669529 30077.455932149664 37481.6642241577 33086.64377896594 31513.314167777502 29607.90413236982 33696.784620753606 36031.73998482876 0.7792759953986531 0.9072144279176437 0.7910797374397393 0.8347489170607314 1.0402401948931534 0.9182638360761135 0.8745987338120849 0.8217173010472514 0.9351972631613602 1.0 15.136980701224557 -6.052187504703747 24.99788738868271 0.9208918919946052 0.8304791316359698 0.36946464141291435 0.065387074859732 428.8180291781258 205403.52291760407 0.019810752998513516 0.025575772086503294 8.867730690631896e-07 6.052187504703747 -0.09041276035863544 T(ph)VHRDSEEEDDYLFDDPLPIPLR ddPTM_A459_Selumetinib_30min_R1 1 TVHRDSEEEDDYLFDDPLPIPLR 23 1 B3KSJ7;Q96SD1-2;Q96SD1-3;Q96SD1 B3KSJ7 DCLRE1C Protein artemis 1 T(0.83)VHRDS(0.17)EEEDDYLFDDPLPIPLR 101.05 6.0346e-05 6077900.0 293.84 527.51 614.82 631.37 470.67 545.32 412.19 598.33 403.61 468.66 True False 300.68590028689005 465.748883967254 531.3308209645184 521.1130817827404 428.09798160353785 539.8345759109441 381.0981764439273 582.4603447502527 684.8966914919278 528.8170761349813 0.5686009659229301 0.8807372246208837 1.0047535243148906 0.985431646026736 0.8095388763396612 1.0208342360206812 0.7206616307273924 1.1014401218041963 1.2951485918300922 1.0 9.046624953718464 -7.909634038156762 6.714247720887781 1.1638290788664716 0.872757963021128 0.42399546604531213 0.14699874392654813 0.1970566738340559 12.047358886592768 0.08022894471403298 0.03808296223216145 1.2313059038977159e-08 7.909634038156762 -0.2910711158453436 T(ph)VIIEQSWGSPK ddPTM_A459_Selumetinib_30min_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;C9JL19;C9JCQ4;C9JL25;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 T(0.91)VIIEQS(0.066)WGS(0.024)PK 196.7 0.00035938 121950000.0 4202.2 6978.6 6821.4 7311.3 3960.0 5994.2 4512.6 5136.4 2834.3 4344.5 True False 4300.103083942178 6161.542267736875 5895.0913472680895 6034.518705098676 3601.818699194785 5933.903790298143 4172.210948884897 5000.165986621424 4809.600090918387 4902.158894013629 0.8771855782139858 1.256903825631023 1.2025500345300926 1.2309920660604965 0.734741320521703 1.2104674529306771 0.8510966370306514 1.0199926389019087 0.9811187672418631 1.0 12.259201531798364 -6.210579457180221 24.997000158788072 0.9736895792288877 1.1544534722598228 0.24389553986175838 0.1505408959010238 494.6668751251478 243122.05149312876 0.04219455955669949 0.054472874640877036 6.157728589038676e-07 6.210579457180221 0.1807638930309351 T(ph)VIIEQSWGSPK ddPTM_A459_Selumetinib_30min_R2 2 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;C9JL19;C9JCQ4;C9JL25;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 T(0.804)VIIEQS(0.148)WGS(0.048)PK;T(0.921)VIIEQS(0.06)WGS(0.019)PK 226.42 2.198e-09 49735000.0 299240.0 223116.0 215483.0 233978.0 156555.0 144686.0 300010.0 222849.0 158924.0 177192.0 True False 282609.438752631 240228.27976898663 201619.05838015134 202109.7927654372 136887.16128054244 164615.18317126206 313961.05945853697 223497.45369536217 190713.2407075729 172076.00655989483 1.642352379059091 1.3960591285884467 1.1716860613566913 1.1745379080208282 0.7955040567081958 0.9566422795496717 1.8245487313145887 1.2988298494570711 1.10830815126565 1.0 17.392686423469605 -4.931917294998416 2.2296161054020733 1.1792547219954734 1.687946518291014 0.2543117687380394 0.25805950683848905 0.722568597951451 5.414448215241199 0.07512015554835656 0.6508588515436966 1.1697221261992979e-05 4.931917294998416 0.5086917962955406 T(ph)VQSLEIDLDSMR ddPTM_A459_Selumetinib_30min_R1 1 TVQSLEIDLDSMR 13 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 T(1)VQSLEIDLDSMR 165.86 0.0008116 3190000.0 584.6 460.6 632.95 849.52 678.41 807.94 601.25 570.79 393.53 421.23 True False 598.2200425664169 406.67273787286933 546.9988665454802 701.1672794654069 617.0479352830137 799.8128571508262 555.8972284308476 555.6507950127802 667.7916677059993 475.2989736276585 1.2586184186357043 0.855614592998154 1.1508521938740608 1.4752131150501704 1.2982311545372682 1.6827573833083567 1.169573803595731 1.1690553227410672 1.4049928671403706 1.0 8.892691476027037 -5.548068893042147 9.010402518832025 1.3289522319651526 1.0436132065600352 0.2199885952224927 0.1985080468635906 0.30787149401069575 101.07069748324845 0.052425870554767454 0.09187825130870587 2.830942881787105e-06 5.548068893042147 -0.28533902540511735 T(ph)VSDNSLSNSR ddPTM_A459_Selumetinib_30min_R2 4 TVSDNSLSNSR 11 0 H0Y7W6;B7ZL14;Q96RU3-4;Q96RU3-3;Q96RU3-5;Q96RU3-2;Q96RU3 H0Y7W6;Q96RU3-5 FNBP1 Formin-binding protein 1 1 T(0.996)VS(0.004)DNSLSNSR;T(0.995)VS(0.003)DNS(0.003)LSNSR;T(0.707)VS(0.292)DNSLSNSR;T(0.816)VS(0.168)DNS(0.016)LSNSR 191.48 4.6739e-05 194382000.0 104740.0 101175.0 106586.0 99581.0 110441.0 96200.0 89908.0 88616.0 74103.0 100827.0 True False 98918.97010744073 108934.79717109991 99728.37280206238 86017.89601319359 96566.41422493289 109450.67678334737 94088.9001493221 88873.85788883148 88925.67061081571 97915.86252999277 1.0102445870518753 1.1125347247769166 1.0185108952240953 0.8784878546808012 0.9862182871069891 1.1178033257871915 0.9609158079009066 0.9076553644370787 0.9081845199859905 1.0 16.579254977269834 -7.510882317567006 24.498820176861198 0.9316090610502854 1.0185779149504204 0.23932259963868208 0.06724224330855547 667.9783663003805 1364139.1742367009 0.03162425839412467 0.020003018304781295 3.08402352665798e-08 7.510882317567006 0.08696885390013498 T(ph)VSEPNLK ddPTM_A459_Selumetinib_30min_R2 2 TVSEPNLK 8 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;F8VWY3;C9JEB6;H0YI41;C9JAH2;C9JF80 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.778)VS(0.222)EPNLK;T(0.925)VS(0.075)EPNLK 105.2 0.033341 60468000.0 146709.0 141061.0 157266.0 165572.0 139863.0 108554.0 149188.0 126443.0 91374.0 132423.0 True False 138555.5011026592 151879.9251173964 147147.6767782741 143020.80797236896 122292.15954891566 123506.32814490118 156125.53761041374 126810.92819623464 109651.3532028754 128599.60391372613 1.0774177904592321 1.1810294938333432 1.1442311819015505 1.1121403458467696 0.9509528476538547 0.9603943121610089 1.2140436895525277 0.9860911257651194 0.8526570056657206 1.0 16.972526673614468 -6.246481242512009 0.5174625540303625 0.9724158996490896 1.1684165452477475 0.29445551344017307 0.09235648694977497 1.7776959075548948 0.9309864379378787 0.07977301621908386 0.17685239009388676 5.669160565026793e-07 6.246481242512009 0.19600064559865793 T(ph)VSFEALPIMR ddPTM_A459_Selumetinib_30min_R1 1 TVSFEALPIMR 11 0 O15084-2;O15084;O15084-4;O15084-1 O15084-2 ANKRD28 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 1 T(0.961)VS(0.039)FEALPIMR 132.56 0.004647699999999999 13385000.0 1625.6 1716.7 2753.5 3340.9 2172.5 2171.0 1873.1 2290.7 1145.2 1672.0 True False 1663.4733171330274 1515.7079659278215 2379.589823892851 2757.474531460093 1975.9977585860272 2149.161711110284 1731.8105589585373 2229.943194757747 1943.3207579013304 1886.6174866591766 0.8817226220449738 0.8033997228615951 1.2612995695839915 1.4615970385936743 1.0473759373900033 1.1391613436786387 0.9179447191625625 1.1819795006281488 1.0300555208690256 1.0 10.881586229571752 -5.251179673959787 24.76238455410056 1.1380821228585272 0.8425611300696326 0.38269863822588224 0.14569295048132433 648.7595646974017 1565809.0042019098 0.03920591121001959 0.10115640001076444 5.608159103117143e-06 5.251179673959787 -0.29552099278889454 T(ph)VSFEALPIMR ddPTM_A459_Selumetinib_30min_R2 3 TVSFEALPIMR 11 0 O15084-2;O15084;O15084-4;O15084-1 O15084-2 ANKRD28 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 1 T(0.745)VS(0.255)FEALPIMR;T(0.959)VS(0.041)FEALPIMR;T(0.994)VS(0.006)FEALPIMR 164.81 0.0015344000000000002 5097100.0 18338.8 17372.100000000002 22958.5 20959.5 20513.800000000003 16587.199999999997 16215.1 13594.0 15641.5 18393.5 True False 17319.60291203298 18704.48420989443 21481.375105324772 18104.77994284579 17936.673048301174 18871.936236390215 16969.134279611095 13633.556289392158 18770.237060025564 17862.43186294767 0.9696105796187423 1.0471409690129283 1.2026008143876499 1.0135674740011649 1.004156275356185 1.0565155059058098 0.9499901474675709 0.7632530886050551 1.0508220383452362 1.0 14.124640887655707 -7.328834350266325 4.594242251153562 0.9180642655555148 1.0523753788178527 0.24386962873039775 0.09052957345040787 0.27239429583993713 11.326635217800328 0.03883515367764108 0.02590587154684749 4.689922322744489e-08 7.328834350266325 0.1343111132623379 T(ph)VSPGS(ph)VSPIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R1 1 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 2 T(0.561)VS(0.485)PGS(0.754)VS(0.2)PIHGQGQVVENLK 69.361 0.02277 29015000.0 1786.5 1906.3 2318.4 2639.2 2084.1 1793.0 1858.8 1909.0 1310.6 1798.6 True False 1828.1219740761267 1683.1095097851735 2003.5740140596263 2178.3132639197433 1895.593522977741 1774.9640479137452 1718.5892194715354 1858.367118694085 2223.9924775632917 2029.4678298476047 0.9007888408920494 0.8293353976995833 0.9872410809340483 1.073342100763093 0.9340347726133129 0.8745958037911 0.8468176702266754 0.9156918337718278 1.0958500769782067 1.0 10.986885755967872 -8.249027430368145 24.431762080727026 1.047925035195532 0.9210303044402958 0.34806939035279827 0.0698965940549022 606.0505823246679 1192961.0936415521 0.05307865396355022 0.01972471858752076 5.636020571692908e-09 8.249027430368145 -0.12689473075523627 T(ph)VSPGSVSPIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R2 1 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 1 T(0.281)VS(0.262)PGS(0.229)VS(0.229)PIHGQGQVVENLK 54.441 0.047413 13576000.0 27820.0 28419.0 44406.0 54185.0 56180.0 35545.0 29072.0 39140.0 29884.0 44846.0 True False 26273.87577228376 30598.64591851241 41548.96630559713 46804.909525661365 49122.16614442764 40441.00110461622 30423.90560507514 39253.89092002417 35861.63502872509 43551.179456098725 0.6032873529583475 0.7025905222465222 0.9540262014598272 1.0747104925790247 1.1279181587709854 0.9285856688538668 0.6985782241728634 0.9013278494465026 0.823436597506504 1.0 15.410424170071018 -5.150230148421477 3.6006280004390065 0.9379248346983774 0.6227158131868388 0.5042033678099294 0.11488458483648481 0.22093308857247554 5.120133925457016 0.034037546557567314 0.10934445724195675 7.075707175867749e-06 5.150230148421477 -0.3152090215115386 T(ph)VSPPTVCTIPTVVGR ddPTM_A459_Selumetinib_30min_R2 2 TVSPPTVCTIPTVVGR 16 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 T(0.998)VS(0.002)PPTVCTIPTVVGR;T(1)VSPPTVCTIPTVVGR 155.37 0.00021409 13934800.0 27265.9 27315.9 30484.0 30883.0 35411.0 26903.0 29413.3 33051.3 27462.8 24940.0 True False 25750.570432045726 29410.94169553795 28522.692628469667 26676.682123853472 30962.353601643397 30608.644048881444 30781.076731348243 33147.47381106273 32956.12737474475 24219.917398097972 1.0631981112399649 1.2143287366391942 1.177654413912642 1.101435718601932 1.278383947092855 1.26377986950877 1.2708993274174225 1.3686039166122776 1.3607035413478679 1.0 14.563906324286165 -6.274400324485444 23.747069835248368 1.2765197623008284 1.1472738661197337 0.22397921475993843 0.1033519009505376 524.9173314263583 961752.3169618843 0.030659014259740557 0.035011814698047934 5.316179978725852e-07 6.274400324485444 -0.12924589618109472 T(ph)VSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQR ddPTM_A459_Selumetinib_30min_R2 1 TVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQR 36 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.148)VS(0.133)S(0.133)DGCS(0.133)T(0.133)PS(0.133)REEGGCS(0.108)LAS(0.063)T(0.012)PATTLHLLQLSGQR 42.38399999999999 0.021658 6453700.0 7628.1 6337.8 7206.7 8226.3 8764.9 6608.1 5220.2 5539.9 4566.2 7653.3 True False 7204.1607397037305 6823.8888807610365 6743.0287680616775 7105.863748840973 7663.774902799821 7518.305792640722 5462.949643630063 5556.0201918201865 5479.56759028793 7432.329343338539 0.9693005257040564 0.918135965930676 0.9072564544122808 0.9560749289467143 1.0311403799225773 1.011567900900307 0.735025237885402 0.7475476307841425 0.7372611380844105 1.0 12.859598716882356 -7.2613139749188145 24.999999649211915 0.7839208003113451 0.9633198293331211 0.4813255273054806 0.08048700675975383 8.934202968285538 1781326.0337616561 0.0315851708602142 0.02287619549861268 5.4788072916106615e-08 7.2613139749188145 0.17939902902177596 T(ph)VSSPIPYTPSPSSSR ddPTM_A459_Selumetinib_30min_R2 2 TVSSPIPYTPSPSSSR 16 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 T(0.625)VS(0.343)S(0.031)PIPYTPSPSSSR;T(0.949)VS(0.038)S(0.013)PIPYTPSPSSSR 234.9 1.4429e-15 20523000.0 49766.0 35839.0 48134.0 48697.0 53083.0 40012.0 48558.0 46729.0 43951.0 39560.0 True False 47000.20494908247 38587.736059451985 45037.110844336654 42064.38459298942 46414.23897195891 45523.289807227564 50816.04321585165 46864.973653597626 52742.42809354494 38417.8000107761 1.2233965749183717 1.0044233675178749 1.172298018931429 1.0949191411582773 1.2081441144193532 1.1849530632794796 1.322721321928842 1.2198765582738238 1.3728643513879195 1.0 15.229487285215606 -6.5262784810920795 1.8113846006920589 1.2439620132754239 1.117464643519781 0.13894380895182523 0.10676451341508451 0.5302868896485012 3.518001641205068 0.03804792879283655 0.04133388388979055 2.9766071382375296e-07 6.5262784810920795 -0.12649736975564285 T(ph)VTNAVVTVPAYFNDSQR ddPTM_A459_Selumetinib_30min_R2 3 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 T(0.921)VT(0.077)NAVVTVPAY(0.001)FNDSQR;T(0.999)VT(0.001)NAVVTVPAYFNDSQR;T(0.991)VT(0.009)NAVVTVPAYFNDSQR 134.29 0.0010223 5643800.0 22180.2 19597.3 20094.7 24151.5 22817.2 18272.1 21241.0 18152.3 22344.7 17350.800000000003 True False 20947.51327837557 21100.349894748695 18801.828879455104 20862.02403633866 19950.69934764389 20788.91591739085 22228.748588243005 18205.120187724966 26814.26436308239 16849.837321207637 1.2431878646098555 1.252258374518029 1.1158463147766204 1.2381142701052181 1.184029196681527 1.2337754674477115 1.3192263025747633 1.0804329941400406 1.59136636466711 1.0 14.040447042350058 -6.997063753542876 21.441192804256417 1.2576079520111203 1.2062165310033173 0.01493929027544083 0.15036873751049368 72.88611230082427 532192.0703514036 0.04964674089582582 0.043417641057737884 1.0067838641885002e-07 6.997063753542876 -0.05139142100780303 T(ph)VTPASSAK ddPTM_A459_Selumetinib_30min_R2 2 TVTPASSAK 9 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 T(0.999)VT(0.001)PASSAK;T(1)VTPASSAK 132.88 0.0076193 879502000.0 412600.0 299850.0 323314.0 398250.0 421060.0 311441.0 491750.0 686100.0 375600.0 530410.0 True False 389669.3437686659 322847.5308302878 302512.3292376671 344007.66298043134 368162.6784758397 354339.17077008827 514617.34938413865 688096.4374100303 450730.4951408492 515095.6851293165 0.7564989477068481 0.6267719574261932 0.5872934640516748 0.6678519601539024 0.7147461900858503 0.6879094137259764 0.9990713652647706 1.3358613890102407 0.8750422652593018 1.0 18.974480929332785 -7.310261982394268 3.8044241504669873 1.0925830929664158 0.6665655694612173 0.7187680012090094 0.11625180803937336 0.11243075824383426 3.405046285770649 0.0486151137111186 0.03256007577830704 4.89483455878469e-08 7.310261982394268 -0.4260175235051985 T(ph)WSPTACGGK ddPTM_A459_Selumetinib_30min_R2 2 TWSPTACGGK 10 0 Q15464;Q15464-2 Q15464 SHB SH2 domain-containing adapter protein B 1 T(0.987)WS(0.012)PTACGGK;T(0.999)WS(0.001)PTACGGK 150.15 0.0016862 35585000.0 129377.0 122431.0 126520.0 129879.0 117754.0 114841.0 117589.0 100219.0 83772.0 95257.0 True False 122186.74427716584 131821.06402228796 118379.84094456061 112189.25614622814 102960.68978588333 130659.30532719751 123057.12149818307 100510.62069785147 100528.74078524843 92506.68290259091 1.32084234828556 1.4249896319501036 1.279689609768129 1.21276920354352 1.1130081260647995 1.4124309858216528 1.3302511519925715 1.0865228061813508 1.0867186848663108 1.0 16.497269972661208 -7.805370002034112 6.140553791223334 1.0607832348189183 1.297140759477944 0.6128049293461125 0.08799185115638768 0.14810889671628447 13.484716905887858 0.05256907400880767 0.025363596063225437 1.5654168274784575e-08 7.805370002034112 0.2363575246590257 T(ph)Y(ph)VVDFIT(ph)PANFEK ddPTM_A459_Selumetinib_30min_R2 1 TYVVDFITPANFEK 14 0 O15060 O15060 ZBTB39 Zinc finger and BTB domain-containing protein 39 3 T(1)Y(1)VVDFIT(1)PANFEK 63.894 0.046474 37155000.0 6384.0 8453.9 29079.0 42395.0 59552.0 39237.0 11695.0 22360.0 39349.0 33224.0 True False 6029.202837176834 9102.286946427106 27208.08879882131 36620.72786454577 52070.54535836513 44641.540591977115 12238.840673202863 22425.063898102726 47219.89950292144 32264.73679368111 0.18686663634453152 0.2821125430104158 0.8432763289781394 1.1350077981022848 1.61385309576004 1.3836015733660019 0.37932560093283574 0.6950332197501318 1.4635141704354218 1.0 14.977670635993928 -5.335659731539561 2.679474291870096 1.0843009843827414 0.19393619492318592 0.49615963300408783 0.34284080915116977 0.26030397272114364 3.587319883294626 0.10421485271545557 0.29212863330254746 4.616791571660944e-06 5.335659731539561 -0.8903647894595554 T(ph)YGGDTGSPEISFTK ddPTM_A459_Selumetinib_30min_R2 1 TYGGDTGSPEISFTK 15 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 T(0.566)Y(0.409)GGDT(0.023)GS(0.001)PEISFTK 103.34 0.013361 7309000.0 41228.0 31879.0 42739.0 41890.0 47632.0 36967.0 32977.0 31925.0 33956.0 36922.0 True False 38936.71280876045 34324.016792858914 39989.21927070478 36184.50973571938 41648.04232451721 42058.86869698548 34510.49584268585 32017.89646453174 40748.148809911305 35855.96592512324 1.0859200639043063 0.9572749166634239 1.115273797231202 1.0091628771424601 1.1615373132462634 1.1729949985119785 0.9624756983190166 0.8929586928823392 1.1364398575959227 1.0 15.12992556247963 -7.29440854085064 24.994952006296828 0.9890484425385795 1.0795337017220565 0.20093349991060616 0.08274088257777656 1068.2301681245515 809854.471191846 0.035077991386404335 0.023650907497274477 5.0768164170495504e-08 7.29440854085064 0.09048525918347705 T(ph)YSAPAINAIQGGSFESPKK ddPTM_A459_Selumetinib_30min_R1 2 TYSAPAINAIQGGSFESPKK 20 1 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 T(0.499)Y(0.002)S(0.499)APAINAIQGGSFESPKK;T(0.5)Y(0.001)S(0.5)APAINAIQGGSFESPKK 151.23 1.4829000000000003e-05 68459000.0 4213.4 4587.8 6267.2 6510.3 5562.700000000001 4701.2 4082.0 4467.9 2607.0 3947.6 True False 4311.564022150771 4050.658243189642 5416.148663265394 5373.39831846647 5059.554767174455 4653.910196348073 3774.091453562945 4349.396778215457 4423.888592253551 4454.3129128802375 0.9679526576777556 0.9093789148662245 1.2159335837416991 1.2063360665409417 1.1358777136074298 1.0448098926527307 0.847289251424088 0.9764461687544668 0.9931696939075136 1.0 12.120987194831695 -7.013775844475327 22.24974774683785 0.9513757067215127 1.0909386870912128 0.29386622959307906 0.09727429635111919 209.29309006112277 338035.0128404938 0.0400987967086194 0.03248454004435786 9.6877774944902e-08 7.013775844475327 0.13956298036970005 T(ph)YSDEANQMR ddPTM_A459_Selumetinib_30min_R1 1 TYSDEANQMR 10 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 T(0.926)YS(0.074)DEANQMR 145.14 0.0021342 18828000.0 5273.3 5774.9 5528.8 5552.0 5714.5 4735.2 5584.2 4946.2 2364.0 4354.2 True False 5396.157629944386 5098.772023321824 4778.019327524531 4582.447423947567 5197.624483976915 4687.568187217605 5162.979298134786 4815.010708478096 4011.5353402713413 4913.103983499631 1.098319442875026 1.0377903745668213 0.9725052316358918 0.9326990512184243 1.0579105391281824 0.9540950492724203 1.0508589509756656 0.980034358045143 0.8164971378061294 1.0 12.262419058025744 -4.988866137567737 2.4555851759495213 0.9738481504186628 1.102816666080839 0.2929226015289472 0.06377046108892133 0.47798851053512637 4.882552042612977 0.016957781893567697 0.10833976993643281 1.025968111302769e-05 4.988866137567737 0.12896851566217615 T(ph)YSDEANQMR ddPTM_A459_Selumetinib_30min_R2 3 TYSDEANQMR 10 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 T(0.844)YS(0.156)DEANQMR;T(0.659)YS(0.341)DEANQMR;T(0.999)YS(0.001)DEANQMR 199.12 0.00044957 210754000.0 108936.0 94053.0 100454.0 102661.0 122150.0 98821.0 104994.0 100525.0 82295.0 95022.0 True False 102881.77322535953 101266.56267193948 93990.89900604541 88678.3946998972 106804.42496514486 112432.69574227836 109876.42904166399 100817.51110719042 98756.29951442004 92278.46796319413 1.114905519090267 1.0974018631554472 1.0185572114562447 0.9609868548670223 1.1574143711157463 1.21840661449996 1.1907049549791933 1.092535597225153 1.0701987331845348 1.0 16.49370643168207 -4.772370164275385 6.899052251360277 1.0955019732140134 1.1152508185063317 0.004241593422494527 0.07860580770189766 1.287901511381462 321.24558149775385 0.021702427458939518 0.1140863921436745 1.6890007239638582e-05 4.772370164275385 0.01974884529231824 T(ph)YSDTDSCSDIPLEDPDRPVHCSK ddPTM_A459_Selumetinib_30min_R2 1 TYSDTDSCSDIPLEDPDRPVHCSK 24 1 Q9HB20 Q9HB20 PLEKHA3 Pleckstrin homology domain-containing family A member 3 1 T(0.439)Y(0.058)S(0.439)DT(0.053)DS(0.008)CS(0.003)DIPLEDPDRPVHCSK 58.319 0.0063481 8040000.0 30890.0 28597.0 45838.0 65571.0 73819.0 44368.0 41175.0 35080.0 42738.0 60743.0 True False 29173.257462467504 30790.297946152215 42888.83298464088 56640.116683715765 64545.19726976686 50479.289267396605 43089.71908671468 35182.076992193375 51286.79419949316 58989.19176073237 0.4945525882232448 0.5219650757555988 0.7270625635727206 0.9601778731509876 1.0941868390326546 0.8557379370808638 0.7304680366107071 0.5964156473764946 0.8694269690542445 1.0 15.848163021793239 -5.389891737957141 3.1174380937326616 0.8577191132452998 0.5027291048774778 0.543930255471134 0.13166015987626656 0.22335897468237223 4.054913513315856 0.04061254715647041 0.09856989970622541 4.074818432638345e-06 5.389891737957141 -0.354990008367822 T(ph)YSFEQPWPNAR ddPTM_A459_Selumetinib_30min_R1 2 TYSFEQPWPNAR 12 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 T(0.935)YS(0.065)FEQPWPNAR;T(0.667)YS(0.333)FEQPWPNAR 141.34 0.002338 70918000.0 2970.8 3609.8 2881.11 3386.4 2816.8 3476.2 3417.0 2339.39 2095.05 2572.55 True False 3040.0138598294748 3187.162937849507 2489.871086804405 2795.028810600874 2562.020937346431 3441.2325841370653 3159.2529389575157 2277.341777790339 3555.1468336021503 2902.761851259007 1.0472832480249588 1.0979760315050122 0.8577593389979546 0.962886021596499 0.8826149262762333 1.185502897058024 1.088361050903043 0.7845430987742221 1.2247462987913342 1.0 11.503210499719637 -6.7310428678208964 24.99990419029216 1.0451481335667308 0.9702323077563613 0.09873124903618036 0.12900077111196204 605.313788058253 497844.6856260007 0.04275202281205714 0.04274691962686714 1.8576210861989705e-07 6.7310428678208964 -0.07491582581036949 T(ph)YSFEQPWPNAR ddPTM_A459_Selumetinib_30min_R2 1 TYSFEQPWPNAR 12 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 T(0.98)YS(0.02)FEQPWPNAR 131.08 0.0048547 32324000.0 15496.0 15832.0 14701.0 18672.0 17972.0 16863.0 16572.0 13959.0 13615.0 18439.0 True False 14634.794355402915 17046.263492096423 13755.153665238564 16128.841389003404 15714.196688281476 19185.7251829271 17342.63083679504 13999.618378963158 16338.380434884632 17906.618159724487 0.8172841027190412 0.9519532577310901 0.7681603272345761 0.9007195688843328 0.877563621902979 1.0714320823615695 0.9685039733410988 0.7818125261893984 0.9124213343440175 1.0 14.128205275506174 -6.5482395013962105 24.9985557315514 0.9389901058765568 0.863296691097333 0.20389536357395865 0.08244597532617061 444.30190188031435 437953.3435853673 0.028389795714788713 0.028390805667418695 2.829830991881595e-07 6.5482395013962105 -0.07569341477922387 T(ph)YSSSGSSGGSHPSSR ddPTM_A459_Selumetinib_30min_R2 1 TYSSSGSSGGSHPSSR 16 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9 H0Y6B5 ABI2 Abl interactor 2 1 T(0.576)YS(0.402)S(0.015)S(0.007)GSSGGSHPSSR 113.67 0.005217899999999999 562470.0 0.0 0.0 459.38 1225.0 1022.8 461.98 340.53 765.29 769.24 858.42 True False 0.0 0.0 429.82399093512623 1058.1528867571315 894.3067200519856 525.6135515631058 356.36531974739387 767.5168671994205 923.1094943614142 833.6351841569876 0.0 0.0 0.5156020272462289 1.2693236884275547 1.0727794808185214 0.6305078786887237 0.4274835401864279 0.9206867485752426 1.1073302949597879 1.0 9.703272358631079 -5.433789903880267 3.5659160031343333 0.8903247862911513 0.005264924933942125 0.7131472171995185 0.23101690562877697 0.1408274726334896 3.3233297427206883 0.06969325731731478 0.15617473100280765 3.683071043416836e-06 5.433789903880267 -0.8850598613572092 down T(ph)YTHEVVTLWYR ddPTM_A459_Selumetinib_30min_R1 1 TYTHEVVTLWYR 12 0 G3V5T9;P24941;Q00526;K7EJ83 G3V5T9 CDK2;CDK3 Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 T(0.585)YT(0.415)HEVVTLWYR 101.61 0.016776 5821200.0 1632.9 1882.7 1725.9 2172.7 1363.1 1364.6 1450.9 1191.5 869.02 1236.3 True False 1670.9433929297004 1662.2726087565165 1491.5322596900928 1793.2787316302013 1239.8078456748506 1350.873362957667 1341.4574448737092 1159.8975494625467 1474.6634692904408 1394.9911475817812 1.1978164849477952 1.191600829609613 1.0692055374513778 1.2855126247495205 0.8887567837430789 0.9683741472477496 0.9616243423473527 0.8314730537704347 1.0571131378480585 1.0 10.446040251605162 -6.2692975088581795 24.993478202099325 0.944174791710311 1.178086630050441 0.6999008231738866 0.07516768957147842 317.9316741249074 1011208.1794887334 0.022032756601468903 0.02543196134695604 5.379011727446632e-07 6.2692975088581795 0.23391183834012985 T(ph)YTHEVVTLWYR ddPTM_A459_Selumetinib_30min_R2 1 TYTHEVVTLWYR 12 0 G3V5T9;P24941;Q00526;K7EJ83 G3V5T9 CDK2;CDK3 Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 T(0.559)Y(0.041)T(0.399)HEVVTLWYR 96.135 0.023586000000000003 4202500.0 14762.0 13001.0 14101.0 14902.0 14928.0 12560.0 12185.0 13782.0 7599.5 13772.0 True False 13941.587136968123 13998.134895196166 13193.757012007964 12872.321892616143 13052.611181986756 14290.025991671962 12751.626644119444 13822.103338267083 9119.612347771264 13374.36657604673 1.0424110224358045 1.046639092446187 0.9864958416526256 0.9624621711558481 0.9759423825995444 1.0684637594175983 0.9534377999596181 1.0334772312149902 0.6818724681963136 1.0 13.70718294513905 -8.223457101409464 24.999927069612912 0.8409359512333755 1.006714317251038 0.41217505837590596 0.08009520336536836 425.36145901253843 279973.6234294148 0.049484991920386114 0.0187026394966769 5.97782089285536e-09 8.223457101409464 0.1657783660176625 TAAALAPAS(ph)LTSAR ddPTM_A459_Selumetinib_30min_R1 2 TAAALAPASLTSAR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 TAAALAPAS(0.9)LT(0.099)S(0.001)AR;TAAALAPAS(0.543)LT(0.162)S(0.294)AR 141.82 0.00055121 7155000.0 4055.2999999999997 5314.6 5444.4 5951.5 4541.8 4637.9 5326.0 4958.6 3223.8 4115.8 True False 4149.780599759818 4692.364161309491 4705.080383948513 4912.182248491348 4130.994991919919 4591.246936876271 4924.2555320127985 4827.081820197219 5470.553142963939 4644.103021286984 0.8935591180339109 1.0103919184827068 1.0131300624430661 1.0577246512352505 0.8895140725743695 0.9886186666901148 1.0603243531510156 1.0394002454449272 1.1779568880984745 1.0 12.18118426088178 -7.316820154621203 3.1653929962918603 1.0769200970121735 0.9779909117100362 0.3410187593367566 0.06414204633041387 0.3127061420928524 6.257162505287464 0.029029235352978452 0.019085113527403934 4.821474180140573e-08 7.316820154621203 -0.09892918530213735 TAAILHGGS(ph)PDFVGNGK ddPTM_A459_Selumetinib_30min_R1 1 TAAILHGGSPDFVGNGK 17 0 H0YME5;Q9P2K8-2;Q9P2K8;Q9P2K8-3 H0YME5 EIF2AK4 Eukaryotic translation initiation factor 2-alpha kinase 4 1 TAAILHGGS(1)PDFVGNGK 68.134 0.02465 10001000.0 2488.6 2844.6 3202.8 3359.9 2862.2 2893.1 2745.4 2801.5 1568.3 2118.5 True False 2546.5795380273453 2511.5529095813386 2767.8773517210884 2773.1565381342652 2603.314515362453 2863.9980407246267 2538.312267665778 2727.1951194455096 2661.290555899977 2390.430110937478 1.0653227326644696 1.050669876558892 1.1578992998191373 1.160107766985369 1.0890569456312138 1.1981099249128122 1.0618642461252732 1.1408805080588444 1.1133103384713778 1.0 11.223054510854759 -10.077917530983262 6.603933985467195 1.000093634933949 1.1167748306952598 0.356083934506775 0.04645222797454878 0.0 1.0139539468262691e-10 0.04493666342579649 0.01089874175102288 8.357617075663379e-11 10.077917530983262 0.11668119576131075 TAAILHGGS(ph)PDFVGNGK ddPTM_A459_Selumetinib_30min_R2 2 TAAILHGGSPDFVGNGK 17 0 H0YME5;Q9P2K8-2;Q9P2K8;Q9P2K8-3 H0YME5 EIF2AK4 Eukaryotic translation initiation factor 2-alpha kinase 4 1 TAAILHGGS(1)PDFVGNGK;TAAILHGGS(1)PDFVGNGK 93.029 0.005000999999999999 17115400.0 139574.0 100827.0 119930.0 139714.0 143726.0 109614.0 120678.0 127901.0 107010.0 124128.0 True False 131817.03583899135 108560.10669009651 112213.83436991103 120684.71217990665 125669.85495325737 124712.33352317903 126289.76611892045 128273.17073484947 128414.99010921842 120544.10211672455 1.0935170906275535 0.9005841412711858 0.930894439457957 1.0011664615747518 1.0425218052689917 1.0345784765348232 1.0476644141132039 1.0641181814987577 1.0652946751793164 1.0 16.879201540100546 -6.099312886791104 3.4316808084912047 1.0454537198593348 0.9672758879850334 0.2667101876227258 0.04978757875971741 0.2881792422728434 6.351504151930803 0.014928441830571584 0.020342432040404493 7.955859652106531e-07 6.099312886791104 -0.07817783187430138 TAAKGEAAAERPGEAAVAS(ph)SPSK ddPTM_A459_Selumetinib_30min_R1 1 TAAKGEAAAERPGEAAVASSPSK 23 2 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 TAAKGEAAAERPGEAAVAS(0.387)S(0.387)PS(0.226)K 63.563 0.0063772 5403300.0 926.18 926.24 2866.5 2481.5 1424.4 1470.4 1302.7 1215.1 807.55 641.23 True False 947.7581919674376 817.7953902027061 2477.2450445574186 2048.1526085241153 1295.563271498245 1455.6091110163798 1204.4362901902127 1182.871600798943 1370.3533688816085 723.538116609129 1.3098939367688311 1.1302727132542998 3.423793422476566 2.8307459710938376 1.7905943609023938 2.011793266453067 1.6646480158292412 1.6348435191534711 1.893961544560759 1.0 9.498925210947016 -8.60858059984255 0.5826920875203112 1.0177248132217345 2.121789449443431 0.18288378610978606 0.6442511662357353 1.8558720872881538 1.4460696978561465 0.7691286391678483 0.32687201908027635 2.462744739959655e-09 8.60858059984255 1.1040646362216966 TAALESNLPGS(ph)PNTSR ddPTM_A459_Selumetinib_30min_R1 4 TAALESNLPGSPNTSR 16 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 TAALESNLPGS(1)PNTSR;TAALES(0.002)NLPGS(0.989)PNT(0.004)S(0.004)R;TAALESNLPGS(0.909)PNT(0.073)S(0.017)R;TAALESNLPGS(0.988)PNT(0.008)S(0.003)R 289.1 1.5004999999999996e-74 73076000.0 6935.0 9143.7 8661.5 9517.2 9044.6 7776.300000000001 9487.0 8131.7 3760.31 7832.300000000001 True False 7096.572006839037 8073.151353209197 7485.315874213879 7855.19967997006 8226.517526953829 7698.077482315478 8771.387951972478 7916.02090051582 6380.971427823919 8837.651998062594 0.8029929225992107 0.913495049927176 0.8469801567039326 0.8888333328458838 0.9308487739455299 0.8710546063595923 0.9925020756526006 0.8957153893648657 0.7220211238485931 1.0 13.109447407592935 -4.7538153682689765 24.671867224984826 0.8940714335750755 0.8029927302906295 0.12296126221572112 0.07417419845595226 525.4825340512768 1700333.0037998867 0.01791183727000592 0.18434611265045123 1.7627252750152973e-05 4.7538153682689765 -0.091078703284446 TAALESNLPGS(ph)PNTSR ddPTM_A459_Selumetinib_30min_R2 1 TAALESNLPGSPNTSR 16 0 Q4KWH8-2;A0A2U3TZV8;Q4KWH8 Q4KWH8-2 PLCH1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 1 TAALES(0.005)NLPGS(0.718)PNT(0.139)S(0.139)R 96.805 0.0079622 8074800.0 9214.4 8604.8 11164.0 10353.0 11131.0 7185.7 7330.6 7215.0 6739.2 9456.6 True False 8702.300536165769 9264.760491207138 10445.72039444414 8942.903540078842 9732.624267597432 8175.46494970997 7671.487425308327 7235.994455492447 8087.228308980872 9183.563386802454 0.9475951947663038 1.0088415684614722 1.1374365215854567 0.9737945025708147 1.059787345899308 0.8902279654821998 0.8353497550126233 0.7879288409868411 0.8806198605437724 1.0 13.164838338406058 -6.84898110529319 5.026037785310148 0.8592703577350381 1.0277269621157499 0.5174236978392848 0.0699769422472322 0.15299244574190707 6.559963637907569 0.024602599830278123 0.02180459721577678 1.415855377770137e-07 6.84898110529319 0.16845660438071175 TAANKS(ph)PCETISSPSSTLESK ddPTM_A459_Selumetinib_30min_R2 1 TAANKSPCETISSPSSTLESK 21 1 Q9C0D5 Q9C0D5 TANC1 Protein TANC1 1 T(0.032)AANKS(0.947)PCET(0.019)IS(0.002)SPSSTLESK 67.214 0.0047798 20478000.0 56311.0 49385.0 48772.0 49201.0 49679.0 43561.0 43531.0 50847.0 40471.0 56103.0 True False 53181.46005079335 53172.67070219694 45634.062618938515 42499.738923540936 43437.87988410501 49561.132342613244 45555.277755040086 50994.95635182599 48566.330854220774 54483.16061690018 0.9761082038676174 0.9759468815710236 0.8375810452667323 0.7800527436794462 0.797271659578262 0.9096596412807929 0.8361350046368135 0.9359764700583068 0.8914007613419538 1.0 15.733522777357331 -8.829413287029501 0.9765207582120009 0.9990475394102016 0.8726902261921825 0.23047568378606675 0.06539822740256757 1.7279830741865678 3.0060579865278885 0.06986100682587183 0.02275013425083945 1.4811079496744155e-09 8.829413287029501 -0.12635731321801913 TAANKSPCET(ph)ISSPSSTLESK ddPTM_A459_Selumetinib_30min_R2 1 TAANKSPCETISSPSSTLESK 21 1 Q9C0D5 Q9C0D5 TANC1 Protein TANC1 1 T(0.034)AANKS(0.135)PCET(0.814)IS(0.012)S(0.004)PSSTLESK 79.236 0.0030918000000000005 17978000.0 68079.0 64699.0 79981.0 80120.0 76795.0 61909.0 62572.0 74173.0 47495.0 61329.0 True False 64295.44172182981 69661.20525992579 74835.10953672855 69207.5177852908 67147.32554398928 70436.40279605253 65481.721984065785 74388.83114999883 56995.32712117851 59558.27241812149 1.0795383934317573 1.1696310593241843 1.2565023547250986 1.162013520127447 1.1274223179710416 1.1826468420971392 1.0994563697946014 1.2490092161801007 0.9569674338612421 1.0 15.862014286425202 -8.273325814703318 24.9534359939074 0.9784836742352304 1.165877756371776 0.653914731330735 0.054502198645885166 486.85294831475073 1022049.0824888966 0.04983212494764937 0.013283807004880592 5.329349291229255e-09 8.273325814703318 0.18739408213654551 TAAPS(ph)PSLLYK ddPTM_A459_Selumetinib_30min_R1 2 TAAPSPSLLYK 11 0 Q9BTC0;Q9BTC0-1;Q9BTC0-2;Q9BTC0-3 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 T(0.045)AAPS(0.478)PS(0.478)LLYK;T(0.002)AAPS(0.877)PS(0.121)LLYK 158.01 0.00056772 47256000.0 7676.799999999999 9194.099999999999 11341.4 11304.099999999999 9403.1 8103.6 9296.7 8231.3 4967.5 7365.6 True False 7855.654503547507 8117.650497778872 9801.300173850863 9330.051139237334 8552.591265252144 8022.085141480104 8595.442434183886 8012.979184969422 8429.484688154786 8311.046507019626 0.9452064185794787 0.9767302458147227 1.1793099900924087 1.1226084622865535 1.0290630978936894 0.9652316509966029 1.0342190272818297 0.9641360060013558 1.0142506940654374 1.0 13.020814433791147 -6.523441193652397 24.18172116334653 0.9958978708589304 1.061204820309668 0.16033157973007506 0.06487080932927104 24.773703360003122 1064995.3867477789 0.023189592286141463 0.023419630585796516 2.99611725907167e-07 6.523441193652397 0.06530694945073756 TAAPS(ph)PSLLYK ddPTM_A459_Selumetinib_30min_R2 1 TAAPSPSLLYK 11 0 Q9BTC0;Q9BTC0-1;Q9BTC0-2;Q9BTC0-3 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 T(0.104)AAPS(0.895)PS(0.001)LLYK 158.86 0.00057871 12625000.0 99709.0 90497.0 93963.0 108930.0 99205.0 83216.0 80050.0 89369.0 64710.0 94374.0 True False 94167.57294675213 97437.82890628176 87917.52287917884 94093.54608526893 86741.98099604748 94678.2486403642 83772.4836160657 89629.04899416569 77653.80814846739 91649.1774069005 1.0274786485935443 1.0631609760519838 0.9592832730930687 1.0266709287254812 0.9464567326222009 1.0330507192663099 0.9140560339580118 0.9779580300675703 0.8472941094026735 1.0 16.4838343115278 -6.286984036451516 0.570756563910213 0.9334330039199265 1.0439347098994347 0.3070359805357852 0.0513682270246491 1.2434745788369876 0.8343903074527105 0.03663724360854069 0.07262440344721004 5.164353517588521e-07 6.286984036451516 0.11050170597950826 TAAQNSRLS(ph)LQR ddPTM_A459_Selumetinib_30min_R1 1 TAAQNSRLSLQR 12 1 Q9P2D3;Q9P2D3-2;Q9P2D3-3 Q9P2D3 HEATR5B HEAT repeat-containing protein 5B 1 TAAQNS(0.002)RLS(0.998)LQR 66.663 0.03195 2253600.0 1368.7 1633.9 1398.8 1709.0 1473.6 1035.0 1547.3 1233.3 569.29 1306.3 True False 1400.588046973409 1442.6022284204976 1208.8506430584052 1410.5552319031697 1340.3131401852104 1024.5888397048109 1430.5859152616229 1200.5888776770112 966.0435507034994 1473.9763294395225 0.9502106777426885 0.9787146507088381 0.8201289389213388 0.9569727842505662 0.9093179540372013 0.6951189237173228 0.9705623399024333 0.8145238520441732 0.6553996366215976 1.0 10.525497641066293 -6.553908698895462 24.99641284620937 0.8220186979179486 0.9239510641814807 0.1694218042438982 0.10640595841578487 348.81417641824066 280987.6411423741 0.034051372083288414 0.03405170897245512 2.7931309754282185e-07 6.553908698895462 0.10193236626353208 TAASVLNNFIES(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 TAASVLNNFIESPSK 15 0 E7EPB1;E7EQS8;Q6N021-2;Q6N021-3;Q6N021 E7EPB1 TET2 Methylcytosine dioxygenase TET2 1 TAASVLNNFIES(0.5)PS(0.5)K 118.72 0.0019917000000000003 2425500.0 14109.0 14804.0 15350.0 12157.0 14697.0 10259.0 14613.0 12732.0 11855.0 12612.0 True False 13324.878262802005 15939.419197637413 14362.397711816335 10501.195628005264 12850.631467152953 11672.084128070272 15292.533455110177 12769.04801210394 14226.33125637586 12247.858790088685 1.0879353274047276 1.3014045533033123 1.172645599362951 0.8573903249524014 1.0492145351603863 0.9529897697314778 1.2485883220245264 1.0425534969783465 1.1615361917699616 1.0 13.580241934252468 -5.546105664290972 24.998184397130984 1.0484692040751264 1.205258856424541 0.25668146941213943 0.11128921144841761 282.9295493350986 304504.10492102493 0.03012139713206965 0.05217525332258302 2.8437691313382153e-06 5.546105664290972 0.15678965234941455 TAAYGHFGR ddPTM_A459_Selumetinib_30min_R1 2 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 ; 106.68 0.018302 19612000.0 7049.200000000001 8757.1 8806.2 9567.5 7968.5 7580.9 7603.3 7776.4 4109.2 6114.700000000001 False True 7213.432644644523 7731.814660934658 7610.366408994083 7896.715729218004 7247.750581952942 7504.6430289064765 7029.776959548055 7570.14461069287 6973.012275906515 6899.581307221805 1.0454884613207194 1.1206208488103115 1.1030185847695275 1.1445210046227727 1.0504623772411679 1.087695425960319 1.0188700801583386 1.0971889848981393 1.0106428151818212 1.0 12.752293100998939 -7.869155171790914 0.5372481545960573 1.0008088043828574 1.1024798508235447 0.44244465865786364 0.03520760996287139 0.7685161094993864 0.5085227262680795 0.034684524676574464 0.020895448205220303 1.3515895590271163e-08 7.869155171790914 0.10167104644068736 TAAYGHFGR ddPTM_A459_Selumetinib_30min_R2 2 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 ; 117.81 0.010416 14008200.0 114774.0 92654.0 124005.0 125121.0 126300.0 100952.0 104019.0 94201.0 81058.0 118500.0 False True 108395.3205567252 99760.2638704337 116026.65330643526 108079.30395423579 110433.06486367418 114857.2216489862 108856.08960973832 94475.10931418491 97271.86494975227 115078.59710002466 0.9419242438497016 0.8668880780995576 1.0082383364961127 0.9391781502193219 0.9596316573766306 0.9980763108291454 0.9459281947547742 0.8209616009836174 0.8452646052437097 1.0 16.81226001312948 -10.351093146369543 4.316184074619237 1.0000006092055023 0.9269757609793314 0.12538516828473745 0.05914651046934705 88878361.69396359 240442337.72402957 979.1720333323577 0.015993383395711415 4.455606754348351e-11 10.351093146369543 -0.07302484822617084 TADAPSEPAAS(ph)PHQR ddPTM_A459_Selumetinib_30min_R2 1 TADAPSEPAASPHQR 15 0 Q5VUB5 Q5VUB5 FAM171A1 Protein FAM171A1 1 TADAPSEPAAS(1)PHQR 80.238 0.019555 5155000.0 40074.0 21801.0 29943.0 37054.0 27237.0 19406.0 40286.0 30207.0 30194.0 26934.0 True False 37846.84750893243 23473.06659873639 28016.49997947341 32007.1812782847 23815.244558130562 22079.000349871494 42159.37882519455 30294.89736896194 36233.643690848796 26156.34543706377 1.4469470744679458 0.8974138476346489 1.0711167600567695 1.2236870535029043 0.9104958724235287 0.84411640773735 1.6118222221310146 1.1582236303560132 1.385271645766897 1.0 14.674873361205833 -7.247036814085789 24.990836621328132 1.3020147097060648 1.0583656792545026 0.19578607295111128 0.2206726604254063 1201.91759246792 2085529.2595231137 0.08146935987092643 0.06281480271681578 5.661912923467399e-08 7.247036814085789 -0.24364903045156217 TADGGEPAGASS(ph)PAGR ddPTM_A459_Selumetinib_30min_R1 2 TADGGEPAGASSPAGR 16 0 O76081-6 O76081-6 1 TADGGEPAGAS(0.163)S(0.837)PAGR;TADGGEPAGAS(0.032)S(0.968)PAGR 182.7 9.0591e-07 8409500.0 4168.6 4396.1 4504.5 4357.0 4137.1 3703.2 3680.8 3574.6000000000004 2236.37 2921.5 True False 4265.7202693164 3881.4025683085547 3892.8136414473756 3596.1317410193715 3762.9000354643313 3665.9491702365744 3403.154292570919 3479.789996062795 3794.956551997727 3296.502982819845 1.2940137750664136 1.1774303219311466 1.1808918911147 1.0908929128112672 1.1414823693699583 1.1120721532309077 1.03235286311188 1.0556004390707894 1.1512067702579485 1.0 11.686720671435907 -1.5228787452803474 0.32894705007889774 1.0544418393587305 3.375628436629076 0.7262402326135018 0.042420385480884976 30.842523794773918 0.43921989702163006 0.038137287771665696 43.47614496814641 0.029999999999999322 1.5228787452803474 2.321186597270345 TADGGEPAGASS(ph)PAGR ddPTM_A459_Selumetinib_30min_R2 2 TADGGEPAGASSPAGR 16 0 O76081-6 O76081-6 1 TADGGEPAGAS(0.278)S(0.722)PAGR;TADGGEPAGAS(0.495)S(0.505)PAGR 140.93 0.00039826 5553600.0 26281.9 22395.6 32139.9 31854.6 27879.7 21047.8 33047.3 26427.5 25919.6 27186.8 True False 24821.257212781624 24113.27050679605 30072.05382527727 27515.948527749973 24377.202838319678 23946.94339709499 34584.06493198267 26504.39964969185 31104.244254134082 26401.846444210507 0.9401333829143802 0.9133175801832487 1.1390132841209513 1.042197885132529 0.9233143178008748 0.9070177514931409 1.3099108429806958 1.003884319443265 1.178108672052925 1.0 14.688351209237483 -7.22427053469894 24.999978911720756 1.1232999054777701 0.9824011709996422 0.31307670010272826 0.10541663611113744 728.4337055100353 489949.21926545963 0.040022107787139743 0.031000047522423718 5.966634917042989e-08 7.22427053469894 -0.14089873447812795 TADGRVS(ph)PAGDDKPK ddPTM_A459_Selumetinib_30min_R2 1 TADGRVSPAGDDKPK 15 2 H7C1Q0 H7C1Q0 BBX 1 TADGRVS(1)PAGDDKPK 105.2 0.0054134 3202500.0 12661.0 10671.0 8844.4 10670.0 10384.0 5839.6 8525.3 8260.5 6425.6 9387.0 True False 11957.352305998742 11489.431387326991 8275.36093305462 9216.727593223339 9079.469085862169 6643.951893389136 8921.74334256147 8284.53668740061 7710.899546264763 9115.972919644973 1.3116923899840225 1.260362606230126 0.9077869149019926 1.01105254200144 0.9959956184485653 0.7288253214389636 0.9786934890224458 0.9087934727786857 0.8458668772093136 1.0 13.15418092353121 -5.232763287301164 4.8072109204426425 0.9189355635616732 1.2964491676097238 0.759741367513908 0.08193010982808742 0.08816100384790272 5.424465598731242 0.021460882954994962 0.05716011303946692 5.851089115223475e-06 5.232763287301164 0.3775136040480507 TADGRVS(ph)PAGGTLDDKPK ddPTM_A459_Selumetinib_30min_R2 3 TADGRVSPAGGTLDDKPK 18 2 C9JA69;Q8WY36-2;Q8WY36 C9JA69 BBX HMG box transcription factor BBX 1 T(0.369)ADGRVS(0.63)PAGGTLDDKPK;T(0.272)ADGRVS(0.727)PAGGTLDDKPK;T(0.297)ADGRVS(0.703)PAGGTLDDKPK 103.58 0.0022861 81804000.0 143162.0 121239.0 141786.0 133678.0 113817.0 85118.0 118402.0 113671.0 86809.0 118923.0 True False 135205.62916289308 130537.64145517189 132663.6431249248 115470.82579258742 99518.29092310995 96842.23187572716 123907.927609112 114001.76379075286 104173.22564611834 115489.38399093824 1.1707191127931018 1.1302999197347385 1.148708552600247 0.9998393081882551 0.8617094271705402 0.8385379549978879 1.0728945235246412 0.9871189874880438 0.9020155969858857 1.0 16.817400716835472 -5.847442409022085 3.7953376682989597 0.9433105849910007 1.1495701042841748 0.6662952505796693 0.06516722077562322 0.14311462358801175 3.9643955738395977 0.02013771579732655 0.0318443281575637 1.4208806206858405e-06 5.847442409022085 0.2062595192931741 TADSSS(ph)SEDEEEYVVEK ddPTM_A459_Selumetinib_30min_R1 1 TADSSSSEDEEEYVVEK 17 0 P45973;F8VNY3 P45973 CBX5 Chromobox protein homolog 5 1 TADS(0.429)S(0.03)S(0.505)S(0.037)EDEEEYVVEK 348.23 3.322499999999998e-175 30427000.0 2009.4 2388.4 2642.7 2100.5 1778.4 1815.2 2427.6 2036.9 1113.3 1673.1 True False 2056.215110388228 2108.765017662965 2283.835855312015 1733.687106268348 1617.544034002022 1796.9407360697314 2244.4841775280265 1982.8747952163344 1889.1887877851457 1887.8586823740836 1.0891785119225275 1.1170142327661305 1.209749371939201 0.9183352135701934 0.8568141509235604 0.951840703357087 1.1889047620373083 1.0503300981844483 1.0007045577211264 1.0 10.882535058965301 -5.759869083458421 24.999998773323792 0.9978615914913584 1.1364840548624835 0.3631772377793431 0.08693939323729076 53.37190565285363 849679.1153276617 0.02716603553089139 0.04404130975739046 1.738324761651942e-06 5.759869083458421 0.13862246337112505 TADSSSS(ph)EDEEEYVVEK ddPTM_A459_Selumetinib_30min_R1 1 TADSSSSEDEEEYVVEK 17 0 P45973;F8VNY3 P45973 CBX5 Chromobox protein homolog 5 1 TADSSS(0.021)S(0.978)EDEEEYVVEK 312.38 2.9190999999999983e-103 28734000.0 5008.9 6508.8 5898.5 6427.0 5681.5 4526.1 6008.7 5074.0 3020.1 4167.4 True False 5125.597624377226 5746.746670140975 5097.516098141266 5304.645099731811 5167.609328150294 4480.571543369994 5555.458921367878 4939.421037325188 5124.889120623302 4702.326383913543 1.090013156447769 1.2221071446253386 1.0840413195433753 1.1280895171119498 1.0989473945978023 0.9528414613451412 1.1814277589009696 1.0504207139306059 1.0898624855465855 1.0 12.19915896319188 -1.5228787469674356 0.08605097412583566 0.9453697231371225 1.5083464446770587 0.2264212207767563 0.06573368530589999 250.00858705377144 1.5615669926886537 1.4144741007647994 16.64551241951682 0.029999999883459395 1.5228787469674356 0.5629767215399362 TADSSSS(ph)EDEEEYVVEK ddPTM_A459_Selumetinib_30min_R2 3 TADSSSSEDEEEYVVEK 17 0 P45973;F8VNY3 P45973 CBX5 Chromobox protein homolog 5 1 TADSSS(0.088)S(0.911)EDEEEYVVEK;TADSSS(0.031)S(0.969)EDEEEYVVEK;TADSSS(0.018)S(0.982)EDEEEYVVEK 373.51 4.066999999999995e-222 35326600.0 130478.0 110429.0 129267.0 147309.0 138936.0 107177.0 106184.0 106769.0 99333.0 120522.0 True False 123226.55510481818 118898.54921480037 120950.10195526764 127245.26007780121 121481.61757640082 121939.65889406239 111121.7663996044 107079.68011344063 119202.37559591593 117042.21670623739 1.0528385276066905 1.0158603669752955 1.0333886811016113 1.0871740441927231 1.0379299110619702 1.0418433820346809 0.9494161126365827 0.9148808278486249 1.0184562369926766 1.0 16.83666947302458 -7.253692850338733 23.806010455694235 0.9635950289009397 1.0446117232713215 0.5702380706173286 0.03129429433011922 206.5740844016706 634828.7051279775 0.012066848255840156 0.009153213138015889 5.575799513766277e-08 7.253692850338733 0.08101669437038173 TADSVS(ph)PLEPPTK ddPTM_A459_Selumetinib_30min_R1 2 TADSVSPLEPPTK 13 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 T(0.001)ADS(0.019)VS(0.98)PLEPPTK;T(0.001)ADS(0.004)VS(0.994)PLEPPTK 179.83 0.00011058 30443000.0 7820.6 9613.8 7695.0 7949.1 7724.5 7577.799999999999 8616.7 7233.2 4205.4 6177.9 True False 8002.804763761411 8488.211826665636 6650.061265609401 6560.938908087466 7025.820338871239 7501.574212091893 7966.735381655027 7041.3520392551345 7136.25664973651 6970.893642841936 1.1480313965167284 1.2176648018983562 0.9539754307452415 0.9411905050114441 1.007879433949721 1.076128054226575 1.142857112708307 1.010107512755635 1.023721923668191 1.0 12.767127900792234 -5.253863228756208 24.9766057853066 1.0230622330031451 1.182848111728554 0.5710552912586984 0.05656661514478426 461.19551197958344 1520433.6568293737 0.01621226833849054 0.041204318198513244 5.57361249639804e-06 5.253863228756208 0.15978587872540895 TADSVS(ph)PLEPPTK ddPTM_A459_Selumetinib_30min_R2 4 TADSVSPLEPPTK 13 0 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 TADS(0.002)VS(0.998)PLEPPTK;TADS(0.004)VS(0.996)PLEPPTK;T(0.001)ADS(0.005)VS(0.995)PLEPPTK;T(0.002)ADS(0.002)VS(0.996)PLEPPTK 184.11 0.00012235 40739900.0 326960.0 285413.0 320243.0 318490.0 324138.0 250453.0 281508.0 294076.0 258433.0 295667.0 True False 308788.872124583 307303.2593525588 299638.91403421527 275111.11257410474 283416.8866095134 284950.6273640302 294598.6797975198 294931.7124730976 310126.8212213403 287130.32547487767 1.0754310664116888 1.0702570647817071 1.043564149967963 0.958140217753403 0.9870670614146287 0.992408680249143 1.0260103293174987 1.0271701952251733 1.080090793991994 1.0 18.131346184298422 -5.528066648388877 24.9075102038072 1.0095008603772793 1.0688607118155915 0.41293548771488686 0.030226521406962463 132.1185136960729 634310.0813971967 0.008910772750316542 0.01550140666540152 2.96437643077604e-06 5.528066648388877 0.05935985143831224 TADSVS(ph)PLEPPTKDK ddPTM_A459_Selumetinib_30min_R1 2 TADSVSPLEPPTKDK 15 1 Q9UMZ2-6;Q9UMZ2-9;Q9UMZ2-4;Q9UMZ2-8;Q9UMZ2-3;Q9UMZ2-7;Q9UMZ2-5;Q9UMZ2 Q9UMZ2-6 SYNRG Synergin gamma 1 T(0.013)ADS(0.002)VS(0.985)PLEPPTKDK;T(0.036)ADS(0.016)VS(0.948)PLEPPTKDK 139.74 0.00021576 20028700.0 8554.0 7999.700000000001 14608.599999999999 14248.099999999999 11165.0 9673.1 9858.1 10173.4 6493.6 7834.1 True False 8753.291556813432 7063.091405040371 12624.832359295833 11759.936804961699 10155.127721340856 9575.797396472082 9114.495580198154 9903.568384139557 11019.164926220807 8839.683045596083 0.9902268567394291 0.7990208889400388 1.4281996644195865 1.3303572927109057 1.1488112943597142 1.0832738399192638 1.0310885054571026 1.1203533354143846 1.2465565642323047 1.0 13.109778926140276 -5.239112084088936 24.96714521493961 1.1742787969455737 0.894623849248616 0.4156209588437202 0.1323084726701078 804.7835139075474 899933.2086910354 0.035600724644368344 0.09402217702740558 5.766176288918754e-06 5.239112084088936 -0.27965494769695765 TAENATSGETLEENEAGD ddPTM_A459_Selumetinib_30min_R1 1 TAENATSGETLEENEAGD 18 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 164.22 4.0883e-05 29231000.0 3373.4 4374.2 4577.4 4756.5 4423.1 4222.9 4508.9 4030.5 2232.9 3548.2 False True 3451.9936565062444 3862.066630489588 3955.814221858408 3925.8665655631517 4023.0313859617295 4180.421460086419 4168.790042863784 3923.5980470908894 3789.068215436497 4003.6460323947886 0.8622125004496034 0.9646373828356363 0.9880529372103932 0.9805728413045763 1.004841924937941 1.0441536105493052 1.041248404362614 0.9800062281589818 0.9464043985851713 1.0 11.967098713910321 -3.7747119618552567 1.050713974277827 1.0029901944291901 4.3230940353858885e-20 0.6945658002268467 0.027172272894371474 7.538812536703776 1.3538418525271396 0.009370409404393055 13.88242653715349 0.00016799178245524397 3.7747119618552567 -1.0029901944291901 TAENATSGETLEENEAGD ddPTM_A459_Selumetinib_30min_R2 2 TAENATSGETLEENEAGD 18 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 ; 155.39 0.00036399 44822000.0 165214.0 159690.0 163271.0 183158.0 190920.0 137260.0 135608.0 142612.0 125707.0 158886.0 False True 156032.0672840435 171937.70951572008 152766.32161602378 158211.56443482707 166934.92275354423 156166.31907777794 141914.04070215425 143026.97730931258 150851.912547047 154298.5483445945 1.0112348363484116 1.114318387051394 0.9900697268703473 1.025360031783926 1.0818956143432337 1.012104914487025 0.9197367196560918 0.9269495976714625 0.9776625520166906 1.0 17.235364963397267 -7.064524121506047 5.111267421506152 0.9508481708734479 1.044734726178391 0.528404141443652 0.03927915875131285 0.1611932161136181 8.320253576304337 0.014876470437096506 0.011629839227660576 8.61937703787236e-08 7.064524121506047 0.09388655530494316 TAES(ph)QTPTPSATSFFSGK ddPTM_A459_Selumetinib_30min_R1 1 TAESQTPTPSATSFFSGK 18 0 A0A3B3ITG9;A0A3B3ISX1;A0A3B3IRQ9;P55265-5;P55265-3;P55265-2;P55265;P55265-4 A0A3B3ITG9 ADAR Double-stranded RNA-specific adenosine deaminase 1 T(0.05)AES(0.47)QT(0.47)PT(0.01)PSATSFFSGK 181.51 1.0957e-09 19352000.0 2002.1 2347.6 2258.5 2151.1 1980.9 2305.3 2708.3 2813.1 1340.8 2142.3 True False 2048.745034591556 2072.741900630368 1951.8081050524788 1775.4507661479847 1801.7279447562994 2282.1107750449282 2504.010750535161 2738.4874497633996 2275.239671842564 2417.285072769109 0.8475396872594039 0.8574668846384547 0.8074381160251798 0.7344813345138999 0.7453518681155545 0.9440801172989778 1.0358773066292526 1.1328773261427287 0.9412376295511453 1.0 11.239171906221692 -6.9628269052558345 3.7385521539221642 1.0352840198601796 0.7992961293264336 0.7796354210439642 0.057601302541200036 0.1068406365319897 3.183884385379236 0.023040054439730038 0.019423348774531557 1.0893641896693918e-07 6.9628269052558345 -0.23598789053374603 TAESQT(ph)PTPSATSFFSGK ddPTM_A459_Selumetinib_30min_R1 1 TAESQTPTPSATSFFSGK 18 0 A0A3B3ITG9;A0A3B3ISX1;A0A3B3IRQ9;P55265-5;P55265-3;P55265-2;P55265;P55265-4 A0A3B3ITG9 ADAR Double-stranded RNA-specific adenosine deaminase 1 T(0.002)AES(0.102)QT(0.859)PT(0.035)PS(0.002)ATSFFSGK 176.17 5.423e-09 23650000.0 4148.9 5327.2 4631.1 4931.7 4520.6 4726.4 5431.2 5489.8 3178.8 4484.3 True False 4245.561297645922 4703.488947451908 4002.2220568113967 4070.471174474464 4111.712528176752 4678.856707227845 5021.520211315796 5344.192670616441 5394.191429633903 5059.903585780946 0.8390597223189308 0.9295609822822288 0.7909680469126357 0.8044562718374855 0.8126068922995398 0.9246928578592095 0.9924142083313577 1.0561846841576958 1.0660660501105899 1.0 12.30489417992932 -7.1640246807078105 2.0212893620463888 1.0426748221132995 0.8367215666748027 0.834518918941862 0.040617768669483065 0.13459127986663233 1.0784547729880642 0.02066916555765226 0.01422755991196537 6.854492716544566e-08 7.1640246807078105 -0.20595325543849685 TAESQT(ph)PTPSATSFFSGK ddPTM_A459_Selumetinib_30min_R2 2 TAESQTPTPSATSFFSGK 18 0 A0A3B3ITG9;A0A3B3ISX1;A0A3B3IRQ9;P55265-5;P55265-3;P55265-2;P55265;P55265-4 A0A3B3ITG9 ADAR Double-stranded RNA-specific adenosine deaminase 1 TAES(0.002)QT(0.753)PT(0.241)PS(0.002)AT(0.002)SFFSGK;TAESQT(0.988)PT(0.012)PSATSFFSGK 166.67 3.333e-07 14659000.0 59273.0 43719.0 59704.0 62852.0 63085.0 48847.0 49471.0 52501.0 58495.0 71473.0 True False 55978.843948618836 47072.106721258446 55862.70964080015 54291.449174252455 55159.69831294439 55575.230861082804 51771.49952492682 52653.769217991554 70195.63448685835 69409.38878084418 0.8065024765650732 0.6781806834502705 0.8048292979092955 0.7821917197063113 0.7947008219177336 0.800687512701749 0.745886117631609 0.75859721779488 1.0113276563851714 1.0 16.08284320418899 -8.262393123331 24.99029218862695 1.0056638634433301 0.7707067861320568 0.8672029971395935 0.03666072270052316 27.215667773226897 713056.5972622298 0.029155480936320238 0.00919049456632352 5.4652102812845925e-09 8.262393123331 -0.23495707731127335 TAESQTPT(ph)PSATSFFSGK ddPTM_A459_Selumetinib_30min_R2 1 TAESQTPTPSATSFFSGK 18 0 A0A3B3ITG9;A0A3B3ISX1;A0A3B3IRQ9;P55265-5;P55265-3;P55265-2;P55265;P55265-4 A0A3B3ITG9 ADAR Double-stranded RNA-specific adenosine deaminase 1 TAES(0.002)QT(0.171)PT(0.336)PS(0.049)AT(0.336)S(0.096)FFS(0.008)GK 129.36 0.001483 9951500.0 21541.0 16184.0 22465.0 18964.0 21694.0 14313.0 15108.0 19209.0 16903.0 21198.0 True False 20343.837455455247 17425.26076023805 21019.6263580426 16381.0704852753 18968.605773179304 16284.485829522362 15810.551935934061 19264.89500977886 20284.07230928056 20585.958660981585 0.9882385265843726 0.8464634097058452 1.0210661890564747 0.7957399873887736 0.9214341719791853 0.7910482138676306 0.7680260218292004 0.9358269550153786 0.9853353270220435 1.0 14.329373014180941 -7.994954276699274 24.99755332412128 0.9819721836775239 0.8741305136640976 0.26069869150025793 0.07890250647372522 181.24821903862698 897941.9060746798 0.04365888063369773 0.020861816766009848 1.0116859607627312e-08 7.994954276699274 -0.10784167001342637 TAFDEAIAELDTLS(ph)EESYK ddPTM_A459_Selumetinib_30min_R1 2 TAFDEAIAELDTLSEESYK 19 0 E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P63104-2 E7EX29;P63104-2 YWHAZ 14-3-3 protein zeta/delta 1 TAFDEAIAELDT(0.297)LS(0.703)EESYK;TAFDEAIAELDT(0.232)LS(0.768)EESYK 211.17 8.4696e-17 11202500.0 4413.200000000001 7072.7 4043.5 3713.2000000000003 4214.8 4792.7 5772.1 5841.9 3108.3 5626.6 True False 4516.018973407651 6244.624995990971 3494.4149093556343 3064.759325396632 3833.5720841833777 4744.4897894234255 5336.705849855631 5686.953834834457 5274.558078750175 6348.828917725192 0.7113152727740784 0.9835869066430037 0.5504030671860812 0.4827282897543798 0.6038234978234317 0.7473015655182268 0.8405811400833576 0.8957484771651577 0.8307922842312261 1.0 12.632274786719856 -7.228524810325619 2.3806651732079063 0.8933472717875318 0.6683009921098264 0.40064432029661645 0.13070647195542126 0.37182892816233687 4.137656689252985 0.06774412269558519 0.04579225808124142 5.908472107585658e-08 7.228524810325619 -0.2250462796777054 TAFQEALDAAGDK ddPTM_A459_Selumetinib_30min_R2 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 133.04 0.018875 2595800.0 27151.0 17703.0 18745.0 22560.0 19087.0 16574.0 21238.0 21153.0 17958.0 15960.0 False True 25642.056114064573 19060.763175883218 17538.96710801285 19487.28908182929 16689.12042005501 18856.918056207876 22225.60908229861 21214.55172793233 21550.101788443506 15499.193330940006 1.6544123017600565 1.2297906587069591 1.131605157347188 1.2573098912785425 1.0767734851554907 1.2166386761925905 1.4339848924867018 1.3687519908267183 1.3904015085368653 1.0 13.919905510678841 -4.760253999873574 24.965637459143657 1.2437760039772312 1.6544128010199637 0.4758669827272861 0.13202709563246068 27.858914660268287 586493.6275835193 0.03422326737931136 0.20539727881176875 1.7367847621028763e-05 4.760253999873574 0.4106367970427325 TAFYNEDDS(ph)EEEQR ddPTM_A459_Selumetinib_30min_R1 4 TAFYNEDDSEEEQR 14 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 TAFYNEDDS(1)EEEQR;TAFYNEDDS(1)EEEQR;TAFYNEDDS(1)EEEQR;TAFYNEDDS(1)EEEQR 321.82 1.561199999999999e-109 67743000.0 7418.9 9555.599999999999 7227.0 7638.799999999999 9048.6 7464.599999999999 8463.0 7980.4 4175.24 7159.1 True False 7591.74593533355 8436.825909722078 6245.61309506941 6304.826978035065 8230.155727660083 7389.512901314525 7824.629096399609 7768.733868007481 7085.077332535759 8078.040220539297 0.9398004624971672 1.044414942162646 0.7731594451819216 0.7804896739687376 1.0188307439636184 0.9147655495111159 0.9686296283230477 0.9617102237563301 0.8770787392864395 1.0 12.979789613895477 -6.287918367652159 24.978427041890896 0.9534074909796056 0.8879405132675122 0.1587798370805652 0.08121888999336291 1696.141990657073 1600016.7866974217 0.026902348424329547 0.030512477190123885 5.153254988564067e-07 6.287918367652159 -0.06546697771209342 TAFYNEDDS(ph)EEEQR ddPTM_A459_Selumetinib_30min_R2 4 TAFYNEDDSEEEQR 14 0 Q8WWQ0 Q8WWQ0 PHIP PH-interacting protein 1 TAFYNEDDS(1)EEEQR;TAFYNEDDS(1)EEEQR;TAFYNEDDS(1)EEEQR;TAFYNEDDS(1)EEEQR 249.54 2.0008e-27 123195000.0 127249.0 93512.0 117860.0 123553.0 108544.0 103150.0 117172.0 111082.0 98548.0 96381.0 True False 120177.00999810708 100684.06971152878 110277.01591626559 106724.86825918681 94907.73232432819 117357.97619752889 122620.7301719132 111405.23022938507 118260.35366118353 93598.23010208843 1.283966693248675 1.0757048461462546 1.178195525663097 1.14024451255949 1.013990672909215 1.253848241249065 1.3100753084558294 1.190249325311754 1.2634892084198162 1.0 16.51419362894059 TAGFPNGS(ph)LGK ddPTM_A459_Selumetinib_30min_R2 1 TAGFPNGSLGK 11 0 Q9NZH0;Q9NZH0-2 Q9NZH0 GPRC5B G-protein coupled receptor family C group 5 member B 1 TAGFPNGS(1)LGK 83.53 0.037914 5702800.0 87296.0 42628.0 94962.0 104520.0 81411.0 67653.0 150150.0 94746.0 81255.0 85660.0 True False 82444.43779357603 45897.43052937638 88852.24830680793 90284.19569294337 71183.42235642576 76971.58665721201 157132.27251658056 95021.69517395544 97508.2704543923 83186.77322859167 0.9910762804445394 0.551739522378796 1.0681054794930909 1.0853191221259233 0.8557060166382279 0.9252863606777878 1.8889093351991382 1.142269275343115 1.1721607494793207 1.0 16.34406653634754 -7.053718665378235 24.999359225327655 1.3261775921341765 0.9070986311298297 0.3473158352361122 0.2596654741090101 344.1763307367252 160170.15037718337 0.0979644284351718 0.07588341678936959 8.836521421742062e-08 7.053718665378235 -0.41907896100434683 TAHNSEAADLEES(ph)FNEHELEPSSPK ddPTM_A459_Selumetinib_30min_R2 1 TAHNSEAADLEESFNEHELEPSSPK 25 0 A0A0D9SGE8;Q5JRC6;Q8IWS0-2 A0A0D9SGE8 PHF6 PHD finger protein 6 1 TAHNSEAADLEES(0.679)FNEHELEPS(0.092)S(0.228)PK 65.111 0.0011952 6462500.0 17069.0 13966.0 21626.0 30593.0 34281.0 20449.0 15350.0 19323.0 18008.0 28130.0 True False 16120.373312620837 15037.147292232115 20234.60670460849 26426.180624131353 29974.3143039716 23265.66413246017 16063.805415447963 19379.22673090514 21610.103185560227 27317.813809482584 0.5901048094494706 0.5504520748659766 0.7407110556403541 0.9673607415450747 1.097244256550533 0.8516663996144586 0.5880340764996311 0.7093988877022877 0.7910626866509687 1.0 14.737554411771194 -5.430648601996323 3.9624646043877005 0.8449893797198059 0.5735085034180529 0.4016350927190354 0.1385474973412473 0.2678288733977189 7.5228463238359256 0.04240566973513345 0.0931337629054892 3.7098076975022265e-06 5.430648601996323 -0.271480876301753 TAHNSEAADLEESFNEHELEPS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 TAHNSEAADLEESFNEHELEPSSPK 25 0 A0A0D9SGE8;Q5JRC6;Q8IWS0-2 A0A0D9SGE8 PHF6 PHD finger protein 6 1 TAHNSEAADLEES(0.005)FNEHELEPS(0.807)S(0.189)PK 101.75 0.00014904 0.0 5409.3 4436.8 9378.3 10191.0 10099.0 6515.2 5339.0 5441.4 5046.3 9247.2 True False 5108.672761143585 4777.088293439456 8774.91038832099 8802.968219544426 8830.273333794497 7412.609660902961 5587.2740790277985 5457.233573127739 6055.701005402744 8980.209308888992 0.5688812571536395 0.531957344102313 0.9771387376945893 0.9802631449615404 0.9833037326929471 0.8254384063816469 0.6221763754990964 0.6076955876435907 0.6743385145164216 1.0 13.132533356062476 -14.52280162687108 0.01597910278797601 1.8010161912806668 1.5111104873082652e-06 0.06705110821069338 0.1787660704457221 27642.525864561914 33.36982832878031 2390.282058508884 1473.4355736056768 3.0005327623990133e-15 14.52280162687108 -1.8010146801701794 TAHNSEADLEES(ph)FNEHELEPSSPK ddPTM_A459_Selumetinib_30min_R1 1 TAHNSEADLEESFNEHELEPSSPK 24 0 Q8IWS0-5;Q8IWS0 Q8IWS0-5 PHF6 PHD finger protein 6 1 TAHNSEADLEES(0.969)FNEHELEPS(0.021)S(0.009)PK 55.988 0.0075334 37331000.0 827.2 828.61 935.17 1233.8 1354.2 1179.9 1415.7 999.34 394.04 698.48 True False 846.4721505489912 731.5959559896618 808.17905052111 1018.3399912943996 1231.7128491034289 1168.0312772634836 1308.9126092133904 972.8342568861954 668.6571004570726 788.1367117713518 1.0740169032940103 0.9282602181357424 1.0254300281288924 1.2920854670069382 1.56281623569486 1.4820160764219596 1.6607684804728677 1.2343470902398803 0.8484024287540843 1.0 9.622302093932673 -5.777347527040973 4.42144726687715 1.3440514986753849 0.9959369636262502 0.22539161911089345 0.23546679324798223 0.26217292161200473 12.111473842664136 0.07011045990148657 0.11424550852068206 1.6697539248022578e-06 5.777347527040973 -0.3481145350491347 TAHNSEADLEES(ph)FNEHELEPSSPK ddPTM_A459_Selumetinib_30min_R2 1 TAHNSEADLEESFNEHELEPSSPK 24 0 Q8IWS0-5;Q8IWS0 Q8IWS0-5 PHF6 PHD finger protein 6 1 TAHNSEADLEES(0.807)FNEHELEPS(0.026)S(0.167)PK 76.693 0.00019722 47482000.0 151510.0 97651.0 192290.0 254560.0 296620.0 166380.0 121440.0 167030.0 157280.0 249210.0 True False 143089.6807425849 105140.51770254616 179918.2707495219 219888.48885950627 259355.94378355503 189297.3347527374 127087.20062879482 167516.02964669504 188740.39477037534 242014.65977465853 0.5912438563672823 0.43443863194255755 0.7434188941985788 0.9085750799734442 1.0716538577664803 0.782173009391222 0.5251219109913695 0.6921730683697852 0.779871743910525 1.0 17.884734914265735 -5.385477060473141 4.936330741163834 0.8073739040410752 0.5155771848673562 0.3955830725294993 0.14988568187819296 0.24625876648938574 8.752640180892184 0.043880579147825886 0.09466013544253012 4.116450899096945e-06 5.385477060473141 -0.2917967191737191 TAHNSEADLEESFNEHELEPS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 TAHNSEADLEESFNEHELEPSSPK 24 0 Q8IWS0-5;Q8IWS0 Q8IWS0-5 PHF6 PHD finger protein 6 1 TAHNSEADLEES(0.093)FNEHELEPS(0.454)S(0.454)PK 49.076 0.024732 36998000.0 1190.6 1484.7 1158.3 1430.5 1740.0 1245.0 1482.2 1088.6 571.68 743.22 True False 1218.3386634956823 1310.8706337816964 1001.0092220864673 1180.6900288106974 1582.6173072219508 1232.476430369555 1370.3964606739335 1059.7267917288539 970.0992061448064 838.6195265758571 1.4527907172281636 1.5631291571925041 1.1936392969212855 1.4078971349874696 1.8871696366096904 1.4696490974898277 1.634109888031536 1.2636562328280065 1.156781085346045 1.0 9.711872612334634 -8.103200747794244 2.2221167092296827 1.0476756476929405 1.5127089546780514 0.5162024245193442 0.17132421809849083 0.2753242369849688 2.4340259649768194 0.15677045728639077 0.049316951983519305 7.884955600653396e-09 8.103200747794244 0.4650333069851109 TAHNSEADLEESFNEHELEPSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 TAHNSEADLEESFNEHELEPSSPK 24 0 Q8IWS0-5;Q8IWS0 Q8IWS0-5 PHF6 PHD finger protein 6 1 TAHNSEADLEESFNEHELEPS(0.111)S(0.889)PK;TAHNSEADLEESFNEHELEPS(0.035)S(0.965)PK 176.68 3.0296000000000004e-20 42890000.0 3748.9 4252.6 4481.7 5356.2 5277.7 4116.200000000001 5407.0 3853.2 1822.46 3283.3 True False 3836.2420759104366 3754.7036150198987 3873.109756215939 4420.8402183263615 4800.3329668536135 4074.794765210571 4999.145636799324 3751.0006190424547 3092.5815127880355 3704.7435370502812 1.0354946401944072 1.0134854349484594 1.0454461199491587 1.1932918362943516 1.2957261194591734 1.0998857881684638 1.349390473808518 1.0124859066571186 0.834762644663482 1.0 11.855157959276303 -7.993593807329166 24.85610293715806 0.9194622599725442 1.1467097628531449 0.42166888094003374 0.11030862256927354 138.32183003525097 536690.3446830547 0.06394664107808776 0.030596414206645467 1.014860133759371e-08 7.993593807329166 0.2272475028806007 TAHNSEADLEESFNEHELEPSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 TAHNSEADLEESFNEHELEPSSPK 24 0 Q8IWS0-5;Q8IWS0 Q8IWS0-5 PHF6 PHD finger protein 6 1 TAHNSEADLEESFNEHELEPS(0.067)S(0.933)PK;TAHNSEADLEESFNEHELEPS(0.04)S(0.96)PK;TAHNSEADLEES(0.012)FNEHELEPS(0.119)S(0.868)PK 123.38 9.8507e-08 56659200.0 137368.0 119967.1 186434.0 264583.0 299727.0 148979.0 127832.0 159911.0 156959.0 231879.0 True False 129733.63648767342 129168.19081497467 174439.03941399138 228546.3389688674 262072.61466662266 169499.50495328798 133776.44129430267 160376.31453530886 188355.18580088523 225184.05077600465 0.5761226696144756 0.5736116317734288 0.7746509524669205 1.0149312892333004 1.1638151714719434 0.7527154093248493 0.5940760050869364 0.7122010372521391 0.8364499401791388 1.0 17.780745122986346 -5.350746433601135 3.8785039573781175 0.8540931059045082 0.5726290766373028 0.35149811503893036 0.1557888723963556 0.2898647489970191 7.966059962277883 0.04745408924429962 0.10987403620234869 4.459165244317728e-06 5.350746433601135 -0.2814640292672054 TAITT(ph)PNFK ddPTM_A459_Selumetinib_30min_R2 1 TAITTPNFK 9 0 Q9BXS6-4;Q9BXS6-6;Q9BXS6-3;Q9BXS6-5;Q9BXS6-2;Q9BXS6;Q9BXS6-7;H0YMD2 Q9BXS6-4 NUSAP1 Nucleolar and spindle-associated protein 1 1 TAIT(0.338)T(0.662)PNFK 139.43 0.0055667 9013400.0 109400.0 114230.0 125940.0 108020.0 97484.0 109940.0 104930.0 89602.0 94052.0 107480.0 True False 103319.98596289878 122991.073692659 117837.15751310445 93307.4896551065 85237.18840198257 125083.23706404593 109809.45291485041 89862.72698559046 112865.02803244718 104376.77313342321 0.9898752649770696 1.178337574542963 1.1289595757331474 0.8939487862479997 0.8166298482232747 1.198381913034943 1.0520487424389207 0.8609456327100699 1.081323216307651 1.0 16.671441180469664 -5.739189384671149 24.99633174433561 0.9849100067583771 1.1069855392827432 0.1687090704377482 0.11438934224558546 417.5369258554796 469070.0670543025 0.03196438625641941 0.055310040137313055 1.823100521631891e-06 5.739189384671149 0.12207553252436609 TAITTAS(ph)IRR ddPTM_A459_Selumetinib_30min_R1 1 TAITTASIRR 10 1 Q8IXS8 Q8IXS8 FAM126B Protein FAM126B 1 TAITT(0.019)AS(0.981)IRR 76.24 0.029761000000000006 2417500.0 1560.6 1718.3 1775.0 1785.5 1292.8 1454.6 1350.1 1157.3 1151.3 1109.1 True False 1596.9589436010097 1517.1206371840017 1533.9647493770867 1473.6959429860206 1175.8664682623778 1439.9680446711284 1248.260870028254 1126.604644559803 1953.6720123749578 1251.4637885488582 1.2760728342389933 1.212276896116337 1.2257364243481659 1.1775777744994547 0.9395928823684625 1.1506270160168608 0.997440662246953 0.9002295191186984 1.5611095025293134 1.0 10.289400831511905 -6.013005324435208 20.024587372098534 1.0823847999439553 1.229821320057528 0.1251975987278472 0.1743189251480636 90.91010805782462 139983.06420847977 0.04894321245182011 0.06655531200255073 9.70498068900061e-07 6.013005324435208 0.14743652011357278 TAITTAS(ph)IRR ddPTM_A459_Selumetinib_30min_R2 1 TAITTASIRR 10 1 Q8IXS8 Q8IXS8 FAM126B Protein FAM126B 1 TAIT(0.001)T(0.081)AS(0.918)IRR 81.676 0.02285 1913200.0 10664.0 10218.0 12270.0 13467.0 12582.0 8961.9 6310.1 8467.2 7372.7 10922.0 True False 10071.337571374337 11001.687743951577 11480.56155856589 11632.77136812921 11001.336675492847 10196.320376971731 6603.532153225941 8491.838150179577 8847.446010449798 10606.653481236006 0.9495301783160274 1.037244005700235 1.0823924415816824 1.0967428500147087 1.037210906810057 0.9613136127252403 0.6225839436451943 0.8006142715232754 0.8341411384940233 1.0 13.372681921043396 -7.039742616364573 7.287119042532768 0.7961845267443977 1.0416472338646137 0.5663800068694548 0.09294754152931996 0.1631445778380258 25.243078132343605 0.034598808480479276 0.027225141393339456 9.125515006974293e-08 7.039742616364573 0.245462707120216 TAKPFPGSVNQPATPFS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 TAKPFPGSVNQPATPFSPTR 20 1 H0Y9Y3;Q9UMS6-5;Q9UMS6;Q9UMS6-3;Q9UMS6-4;Q9UMS6-2 H0Y9Y3 SYNPO2 Synaptopodin-2 1 TAKPFPGSVNQPAT(0.009)PFS(0.734)PT(0.257)R;TAKPFPGSVNQPAT(0.005)PFS(0.728)PT(0.267)R 136.22 5.7391000000000013e-05 31940000.0 118738.0 109570.0 117854.0 132759.0 138395.0 91612.0 103252.0 109500.0 88186.0 125972.0 True False 112139.0173058747 117973.66667692071 110271.4019497333 114676.99517795084 121008.58283300223 104230.7214290645 108053.42258995668 109818.62687129903 105825.66412271303 122334.8610454372 0.9166562690926212 0.9643503549908258 0.9013898492006843 0.937402423135609 0.9891586241149826 0.8520116059996299 0.8832594541454856 0.897688736741284 0.8650491218803741 1.0 16.900476053205786 -6.76755540901423 24.999115906242686 0.8921859429186041 0.9405563991014482 0.17889289864646352 0.04373527051801525 220.353127401992 900681.2456154043 0.014410692392015636 0.013031036820198091 1.707829814451246e-07 6.76755540901423 0.04837045618284408 TALATS(ph)PITVGDLGIVR ddPTM_A459_Selumetinib_30min_R1 2 TALATSPITVGDLGIVR 17 0 P13994 P13994 CCDC130 Coiled-coil domain-containing protein 130 1 TALAT(0.159)S(0.84)PIT(0.001)VGDLGIVR;TALAT(0.041)S(0.823)PIT(0.136)VGDLGIVR 174.4 2.5185e-07 10927100.0 2790.1000000000004 3058.6 3147.4 3256.5 2993.8 2766.9 2672.9 2640.3 1581.8400000000001 2233.4 True False 2855.103901410471 2700.4976900954366 2720.0003674306727 2687.8134070758742 2723.011318598318 2739.0674981441925 2471.281001035864 2570.2706670969073 2684.2669469775064 2520.0786451582558 1.1329423813403157 1.0715926248110605 1.0793315409646123 1.0665593362492405 1.080526325569224 1.0868976265509305 0.9806364598120201 1.0199168474504094 1.0651520547323792 1.0 11.299253041883063 -7.240953022988964 24.748780207694825 1.0180860784595305 1.0841617939143842 0.6307190140193828 0.026152529351206363 490.5387041925717 592601.7777297493 0.010007869971663495 0.007740993545284809 5.7417856692020246e-08 7.240953022988964 0.06607571545485369 TALATS(ph)PITVGDLGIVR ddPTM_A459_Selumetinib_30min_R2 1 TALATSPITVGDLGIVR 17 0 P13994 P13994 CCDC130 Coiled-coil domain-containing protein 130 1 TALAT(0.069)S(0.93)PIT(0.001)VGDLGIVR 105.63 0.004528 0.0 5764.1 5436.8 5968.0 5603.1 7828.4 4604.9 4625.7 4030.5 4265.2 4285.0 True False 5443.754397520521 5853.785077932661 5584.025377467092 4839.948114113376 6844.926405216043 5239.183175879791 4840.804215650663 4042.228087714804 5118.359179645241 4161.28091623295 1.30819199835433 1.4067267256813487 1.3419006046152966 1.1630909355898031 1.6449085132691534 1.259031361098934 1.1632966658816342 0.9713903408794808 1.2299960715650742 1.0 12.022811968568995 -7.246138743331524 3.013416382074043 1.0791191851116244 1.3661639074504428 0.5036084994673196 0.13143420553090887 0.21951687656033278 4.049977818370155 0.05641737732129984 0.0390172267277854 5.673633218417262e-08 7.246138743331524 0.2870447223388184 TALFEVMFSEECIMDVIGCLEYDPALSQPR ddPTM_A459_Selumetinib_30min_R1 1 TALFEVMFSEECIMDVIGCLEYDPALSQPR 30 0 Q6IN85-2;Q6IN85;H0YIY8;G3V5Z3;Q6IN85-5 Q6IN85-2 SMEK1 Serine/threonine-protein phosphatase 4 regulatory subunit 3A 0 40.756 0.020851 24015000.0 1768.3 2630.4 2633.5 3221.1 2798.3 2183.7 2926.2 2222.6 1026.9 2127.8 False True 1809.4979494871616 2322.4315451602147 2275.885164780034 2658.5953525355744 2545.1942590799913 2161.7339606409605 2705.4743781028624 2163.649427977723 1742.5742981914727 2400.9238565271503 0.7536673620730876 0.9673074549392533 0.9479205925639056 1.1073218108554 1.0600895368508367 0.9003758927064979 1.1268472220590258 0.9011736969898595 0.7257932372382869 1.0 11.229373934980691 -10.447213008653035 13.610797835813772 0.9999999964074364 0.955368430081791 0.009676171139638923 0.12767484681586164 0.0 0.0 0.12572298027090384 0.030492301828619575 3.570976493127964e-11 10.447213008653035 -0.044631566325645466 TALIHDGLAR ddPTM_A459_Selumetinib_30min_R1 2 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 ; 126.39 0.0048684 51602000.0 11023.599999999999 12777.5 13228.4 14312.5 12548.0 11843.2 11900.5 11409.2 6788.7 9876.8 False True 11280.428431808336 11281.504359901406 11432.055938399924 11813.090553899414 11413.035615529327 11724.068160765233 11002.835703852486 11106.590953695426 11519.92807296957 11144.58348817903 1.0121893244169595 1.0122858671091304 1.025794813285379 1.0599849304758193 1.0240881256473193 1.0519969789091586 0.9872810155285844 0.9965909417320169 1.0336795525098506 1.0 13.444055078626496 -10.154083985692946 7.02734928274883 0.9999999663415893 1.0226381565155984 0.09242667938988636 0.021297028197522674 0.0 0.0 0.021857307673266355 0.005301175778147093 7.01319661160497e-11 10.154083985692946 0.022638190174009143 TALIHDGLAR ddPTM_A459_Selumetinib_30min_R2 2 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 ; 133.75 0.0031158 23938800.0 121697.0 119968.0 131520.0 144406.0 142948.0 113908.0 101899.0 111765.0 97843.0 119037.0 False True 114933.56793169002 129169.15984208112 123058.14638814898 124737.65368575526 124989.59426866584 129597.79304612802 106637.505409038 112090.21764630816 117414.33396183744 115600.09251473077 0.9942342210240376 1.117379381211319 1.064515985335114 1.0790445835487554 1.0812239986117536 1.1210872779328749 0.9224690317220059 0.9696377849526776 1.0156941176052734 1.0 16.818783026864416 -7.258478333902646 24.99997984672174 0.9744200485583131 1.077937286343648 0.6007906977602067 0.03961771104168391 171.42622516040245 1447350.0786822685 0.015109781132889164 0.011203454504377706 5.5146971343464844e-08 7.258478333902646 0.10351723778533495 TALINST(ph)GEEVAMR ddPTM_A459_Selumetinib_30min_R2 1 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 T(0.001)ALINS(0.3)T(0.699)GEEVAMR 158.14 0.00072033 4545300.0 14565.0 13523.0 14915.0 17577.0 20553.0 13711.0 10905.0 16335.0 11221.0 15226.0 True False 13755.535608314638 14560.170616701627 13955.385138224148 15182.982277983763 17970.948393848717 15599.565793934255 11412.104107847555 16382.532145595165 13465.513540935774 14786.38581810104 0.9302838284846817 0.9847011160007413 0.9437996079569623 1.0268217307976113 1.2153712621139126 1.0549951817730703 0.7717980748126569 1.1079470228309727 0.9106697002625013 1.0 13.851981842433364 -10.63376286891627 14.610218485614931 0.9999895309869196 0.9983689728637387 0.0 0.11399086660546888 0.0 0.0 0.11259492785040999 0.02730828120212001 2.3240053906279933e-11 10.63376286891627 -0.0016205581231808486 TALPAQSAAT(ph)LPAR ddPTM_A459_Selumetinib_30min_R1 2 TALPAQSAATLPAR 14 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 TALPAQSAAT(1)LPAR;TALPAQSAAT(1)LPAR 171.15 0.00034201 114820000.0 8838.7 6564.9 4760.9 5667.2 4105.2 6208.9 3846.1 4282.9 4922.9 3343.1000000000004 True False 9044.624512883667 5796.2784560607915 4114.39592975176 4677.529906519392 3733.8853848319277 6146.444103230143 3555.985580487125 4169.303579180147 8353.801745609895 3772.2194495516073 2.39769309125395 1.536569792287609 1.0907095901434967 1.239994111974423 0.98983779569764 1.6293972780297161 0.9426772827094708 1.1052653841959643 2.2145587915366076 1.0 11.881197892162518 -4.790760240469051 3.0874953651097443 1.27012254930639 2.5601457452745002 0.4568486112570269 0.36653786468267363 0.3079039537305579 4.409812179258129 0.09022982470473773 0.9735549457209208 1.6189735724078767e-05 4.790760240469051 1.2900231959681103 TALPAQSAAT(ph)LPAR ddPTM_A459_Selumetinib_30min_R2 3 TALPAQSAATLPAR 14 0 A0A087WUZ3;Q01082 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 TALPAQS(0.001)AAT(0.999)LPAR;TALPAQSAAT(1)LPAR;TALPAQSAAT(1)LPAR 140.93 0.001306 24064700.0 108881.0 67111.0 82149.0 106240.0 65836.0 110495.0 57484.0 51723.0 37912.0 66882.0 True False 102829.82990517723 72258.19790412365 76863.62277706835 91769.92872577769 57565.09309869238 125714.68327625739 60157.11990238508 51873.505366796395 45495.4593497867 64950.94287969474 1.5831922578190065 1.1125042178057947 1.1834104228392626 1.412911416786641 0.8862857188280886 1.9355328452908247 0.9261931734202995 0.7986566948362704 0.7004587975582677 1.0 15.987062848686596 -7.499509115451771 24.97943049562944 0.8222195001551776 1.3249312091619352 0.44055448749155246 0.2741940281362755 684.4205577847448 731568.8490037519 0.11019469147261464 0.07374560668240975 3.165854014297749e-08 7.499509115451771 0.5027117090067575 TALPTS(ph)GSSAGELELLAGEVPAR ddPTM_A459_Selumetinib_30min_R1 1 TALPTSGSSAGELELLAGEVPAR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 TALPT(0.156)S(0.758)GS(0.081)S(0.005)AGELELLAGEVPAR 157.0 4.0082e-11 0.0 646.3 1073.4 1114.7 1203.0 976.52 937.85 980.41 899.04 531.57 767.48 True False 661.3575325191165 947.7258289898786 963.3298626088111 992.9186331067941 888.1939384186087 928.4160804996678 906.4568843673808 875.1945387065116 902.0354656632991 865.9935338882681 0.763698003089762 1.0943797983509607 1.1123984474612736 1.1465658740529374 1.0256357624642551 1.0720820008102434 1.046724772063175 1.0106247962117356 1.0416191696180508 1.0 9.758212442599524 -4.757976995365545 24.998699390353302 1.0645038711763049 0.7636975815546114 0.8039196130570445 0.04403670941135815 44.039685397171155 317920.7151281792 0.011674281942629434 0.08308738253814733 1.745914631793336e-05 4.757976995365545 -0.3008062896216934 TALPTS(ph)GSSAGELELLAGEVPAR ddPTM_A459_Selumetinib_30min_R2 1 TALPTSGSSAGELELLAGEVPAR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 TALPT(0.046)S(0.67)GS(0.279)S(0.005)AGELELLAGEVPAR 131.3 4.3612e-06 0.0 8322.6 8327.1 7444.3 6664.0 7598.7 4796.7 7239.1 6537.1 6930.0 5113.9 True False 7860.063210007506 8965.761794153375 6965.341842741003 5756.351703958799 6644.083372760093 5457.401884892743 7575.73249400452 6556.121878724836 8316.193640378295 4966.248419492108 1.5826963426069098 1.8053389675320133 1.4025359294155768 1.1590945957043957 1.3378475685353604 1.0988982877845777 1.5254437261475697 1.3201357090782266 1.6745424187275717 1.0 12.277940713838031 -5.396389794454457 5.058908640874464 1.3155749739817877 1.6898204235937042 0.3894509540021822 0.19248823197586235 0.2164313889135543 7.904924954388227 0.049285541503816116 0.10574715528289737 4.014303513603211e-06 5.396389794454457 0.3742454496119165 TALPTSGS(ph)SAGELELLAGEVPAR ddPTM_A459_Selumetinib_30min_R1 2 TALPTSGSSAGELELLAGEVPAR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 T(0.002)ALPT(0.068)S(0.22)GS(0.542)S(0.168)AGELELLAGEVPAR;TALPTSGS(0.5)S(0.5)AGELELLAGEVPAR 281.36 6.932199999999997e-79 7815700.0 4358.389999999999 5511.299999999999 5521.9 5525.799999999999 5497.0 5072.3 5407.299999999999 4468.0 2323.58 3951.64 True False 4459.932007049346 4866.0344338661425 4772.056309625539 4560.822762112659 4999.7973205741755 5021.277267279916 4999.423007557797 4349.494125890608 3942.945552431339 4458.87148623317 1.000237845118311 1.0913152462209539 1.0702385848884257 1.022864815950463 1.1213145155699422 1.1261318660524713 1.1212305676433123 0.975469721278071 0.8842922619782249 1.0 12.122462903500727 -7.897944840613003 5.2258419772134195 0.9384589708082751 1.080052590780767 0.602654425291439 0.047189585381091595 0.13316391769074187 5.610389729185559 0.027258174615674778 0.012680232277581483 1.2648969908017632e-08 7.897944840613003 0.14159361997249187 TALPTSGSS(ph)AGELELLAGEVPAR ddPTM_A459_Selumetinib_30min_R1 1 TALPTSGSSAGELELLAGEVPAR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 TALPTSGS(0.029)S(0.971)AGELELLAGEVPAR 240.94 3.5549999999999996e-37 9918800.0 2651.7 3410.6 3258.5 4077.2 3681.9 2965.0 3883.6 3241.2 1743.1 2813.3 True False 2713.4794506899884 3011.2853664550767 2816.0135976592896 3365.193558522877 3348.8727950922403 2935.1747920046014 3590.656925295703 3155.2328470986226 2957.913389013103 3174.414458862596 0.8547968407572835 0.9486112810656838 0.8870970171514017 1.0600989890049324 1.054957642894606 0.9246350248342445 1.131124171662905 0.9939574330911893 0.9317981087047259 1.0 11.632274786719856 -5.752518269537252 24.999946829235633 1.0164328505946048 0.9020126389811142 0.43244750973391355 0.06126443277092548 186.00713106218856 521249.0894072591 0.016517537615837276 0.02807752423107633 1.7679978415145462e-06 5.752518269537252 -0.11442021161349059 TALPTSGSS(ph)AGELELLAGEVPAR ddPTM_A459_Selumetinib_30min_R2 1 TALPTSGSSAGELELLAGEVPAR 23 0 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 TALPTSGS(0.115)S(0.884)AGELELLAGEVPAR 169.51 3.4956e-13 0.0 6530.7 7023.3 7632.7 8801.5 9959.8 6868.5 4604.5 4413.1 5094.2 8960.1 True False 6167.74983846347 7561.964526531129 7141.6203918554065 7602.720516565628 8708.560882258282 7814.573528964881 4818.618373643658 4425.941390371968 6113.182343840564 8701.398631864377 0.7088228110682429 0.8690516141668698 0.8207439624364423 0.8737354577371725 1.0008231148458913 0.8980824646221865 0.5537751547202949 0.5086471241719974 0.7025516934087116 1.0 13.0870315979314 -7.2505019471817125 24.80589511217777 0.6502974189344234 0.8671878457917903 0.23909528650353518 0.14159784582042062 723.7515936047607 1641457.9971148681 0.0533002733918483 0.040873974124834095 5.616917599760134e-08 7.2505019471817125 0.21689042685736692 TALPTSGSSAGELELLAGEVPARS(ph)PGAFDMSGVR ddPTM_A459_Selumetinib_30min_R1 5 TALPTSGSSAGELELLAGEVPARSPGAFDMSGVR 34 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 TALPTSGSSAGELELLAGEVPARS(0.999)PGAFDMS(0.001)GVR;TALPTSGSSAGELELLAGEVPARS(1)PGAFDMSGVR;TALPTSGSSAGELELLAGEVPARS(0.824)PGAFDMS(0.176)GVR;TALPTSGSSAGELELLAGEVPARS(0.741)PGAFDMS(0.259)GVR;TALPTSGSSAGELELLAGEVPARS(0.973)PGAFDMS(0.027)GVR 141.82 2.7246000000000004e-26 150790000.0 4533.63 3994.5699999999997 8243.3 9075.1 7114.9 5531.74 4949.5 4542.52 2795.7400000000002 3090.4399999999996 True False 4639.25475809166 3526.8838873747864 7123.905137205713 7490.304145725252 6471.358551237623 5476.095718018055 4576.155230134692 4422.037613415536 4744.166587229362 3487.1280774347993 1.3303941395534826 1.0114007312198388 2.042914679074879 2.1479865320103952 1.8557845905098167 1.5703741292021542 1.3122991552122751 1.2681030106208415 1.3604795929145412 1.0 11.767823637961303 -7.229199184212938 2.9343878848757323 1.2450404514355788 1.6884571733093696 0.30096521121063424 0.3206835536905711 0.4113127295318603 7.10771226899169 0.15998641633788968 0.11172762440951131 5.899304532397509e-08 7.229199184212938 0.4434167218737908 TALPTSGSSAGELELLAGEVPARS(ph)PGAFDMSGVR ddPTM_A459_Selumetinib_30min_R2 2 TALPTSGSSAGELELLAGEVPARSPGAFDMSGVR 34 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 TALPTSGSSAGELELLAGEVPARS(0.865)PGAFDMS(0.135)GVR;TALPTSGSSAGELELLAGEVPARS(1)PGAFDMSGVR 102.91 5.8291e-12 22341000.0 29687.6 38394.0 34351.4 33791.5 33788.2 24783.2 11849.4 12644.3 12366.2 33748.1 True False 28037.68204087893 41338.696343832155 32141.268322976408 29189.039406411128 29543.424245659484 28196.860840509926 12400.420579140662 12681.092819623454 14839.78554049728 32773.70466490578 0.855493217124819 1.2613373058218165 0.9807029340016422 0.8906237395147724 0.9014368240553137 0.8603501230272341 0.3783649332880907 0.3869288793952678 0.4527954862663965 1.0 15.00025114060833 -7.094961305457103 3.7113382363967666 0.5050817528416348 0.9833485522281086 0.49987371713468065 0.19745365849103466 0.17941557920589338 4.540248153589662 0.07718815259094365 0.059528746945990425 8.035977175257689e-08 7.094961305457103 0.47826679938647376 TAMPS(ph)PGVSQNK ddPTM_A459_Selumetinib_30min_R1 3 TAMPSPGVSQNK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 TAMPS(1)PGVSQNK;T(0.002)AMPS(0.997)PGVS(0.001)QNK;T(0.002)AMPS(0.99)PGVS(0.008)QNK 163.45 0.0019002 21305600.0 8657.7 10274.4 7813.5 8412.6 8233.7 7641.4 9169.8 8532.9 4824.6 8923.8 True False 8859.407565048354 9071.468471561026 6752.469616483305 6943.497334060033 7488.9632887778025 7564.534453836072 8478.114603351669 8306.57977323455 8186.993825157832 10069.256655172932 0.8798472288912175 0.9009074634025435 0.6706025923983497 0.689573974707747 0.7437453970279383 0.751250535455356 0.841980187186525 0.8249446863554886 0.8130683431285749 1.0 13.297669562449316 -9.11114585247047 0.6969196365213169 1.0034811096515934 0.7746256146579693 0.4465533326873925 0.07145239667517969 2.0809994311636797 1.567687698208398 0.09815324085007698 0.02970930252198518 7.742017479845165e-10 9.11114585247047 -0.22885549499362412 TAMPS(ph)PGVSQNK ddPTM_A459_Selumetinib_30min_R2 5 TAMPSPGVSQNK 12 0 Q86UU0-3;Q86UU0-4;Q86UU0-2;Q86UU0;A0A087WZX0 Q86UU0-3 BCL9L B-cell CLL/lymphoma 9-like protein 1 T(0.003)AMPS(0.919)PGVS(0.079)QNK;T(0.001)AMPS(0.994)PGVS(0.005)QNK;T(0.05)AMPS(0.583)PGVS(0.367)QNK;T(0.015)AMPS(0.98)PGVS(0.005)QNK;T(0.004)AMPS(0.986)PGVS(0.01)QNK 174.94 0.00012235 135325200.0 259811.0 232802.0 272780.0 288509.0 279214.0 218960.0 242682.0 256386.0 207908.0 262143.0 True False 245371.74472583848 250657.16482358787 255229.63178040794 249213.5764942153 244136.64111516945 249119.75247902004 253967.19386526017 257132.04081301298 249495.40943488764 254574.25046069006 0.9638513882759223 0.9846131899435483 1.0025744210914178 0.9789425915748594 0.9589997443707201 0.9785740389226354 0.9976154045653426 1.0100473254765328 0.9800496671732845 1.0 17.95772697611381 -7.261966219074119 10.122000136157764 0.9977728340297816 0.9785323237329472 0.33872496325059887 0.012969063994128375 0.12045221581387447 373.8808239731453 0.0055002635210122065 0.003971206015306537 5.470585133410892e-08 7.261966219074119 -0.01924051029683438 TAMSTPHVAEPAENEQDEQDENGAEASADLR ddPTM_A459_Selumetinib_30min_R1 1 TAMSTPHVAEPAENEQDEQDENGAEASADLR 31 0 P26038 P26038 MSN Moesin 0 130.53 5.9378e-18 7259500.0 985.66 993.83 1060.7 1055.7 964.78 1009.4 1070.1 949.21 603.16 794.25 False True 1008.6239602395049 877.4719215809677 916.6627660080424 871.3418129433438 877.5158193457434 999.2463524618704 989.3814954575469 924.0338673313845 1023.5184669365756 896.1997241501498 1.1254455151679108 0.9791030926873567 1.0228331267087782 0.9722629782882624 0.9791520748099716 1.1149817674954519 1.1039743360730887 1.0310579689227526 1.142065143913272 1.0 9.807676472204362 -6.761201968177308 24.999943800849024 1.0819543726355487 1.0116994195943847 0.23639208595553096 0.05588844452592519 8.561938156258403 901632.8206849638 0.018390878587080987 0.01732353389064294 1.7329978815435867e-07 6.761201968177308 -0.07025495304116403 TANDMIHAENMR ddPTM_A459_Selumetinib_30min_R2 2 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 ; 122.97 0.0047949 14418300.0 149257.0 102908.0 120673.0 119721.0 105135.0 106859.0 147318.0 122565.0 105753.0 109972.0 False True 140961.89346311145 110800.71269862707 112909.03055882802 103414.79326975564 91927.0013811748 121577.85728057926 154168.57890507893 122921.64385827188 126906.55498570367 106796.82261842919 1.319907184568117 1.0374907228701293 1.0572321141260628 0.9683321163892947 0.86076532173263 1.138403318560897 1.443568966989802 1.150985964230926 1.1882989762637777 1.0 16.70450919954444 -6.996708044233878 24.972958844181147 1.2201085770835693 1.0396702890346083 0.17204905697854023 0.14836243658824916 143.2056011755163 1086354.1715587024 0.052748216736542 0.04629248810163835 1.0076088092611687e-07 6.996708044233878 -0.180438288048961 TANS(ph)PGSGARPDPVR ddPTM_A459_Selumetinib_30min_R1 1 TANSPGSGARPDPVR 15 1 Q13206;A0A3B3ISR7;E9PIF2 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 T(0.001)ANS(0.906)PGS(0.093)GARPDPVR 120.99 0.0081979 6171200.0 1376.9 1641.9 1555.3 1788.7 1317.4 1269.7 1364.4 1243.4 672.87 1305.1 True False 1408.9790910189872 1449.6655847013985 1344.0988026513712 1476.3371230574592 1198.2414026058607 1256.9279707953606 1261.4822095152574 1210.420992867588 1141.8112455196188 1472.6222977505317 0.9567823963899221 0.9844109972501434 0.9127247391979033 1.0025225920540535 0.8136787039257827 0.8535304488566757 0.8566230536113733 0.8219493856072512 0.7753591992079467 1.0 10.524171736056777 -6.264274744731484 24.996909993210917 0.8447762613319401 0.9618898520736354 0.4504774303400726 0.0593462425118965 209.73079273869325 1849007.7850270823 0.017042215870554683 0.02020817809000748 5.441582968089266e-07 6.264274744731484 0.11711359074169536 TANS(ph)PGSGARPDPVR ddPTM_A459_Selumetinib_30min_R2 1 TANSPGSGARPDPVR 15 1 Q13206;A0A3B3ISR7;E9PIF2 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 T(0.182)ANS(0.661)PGS(0.157)GARPDPVR 111.01 0.015952 11965000.0 11109.0 8772.7 8780.4 9619.0 9436.3 6262.7 7562.8 7260.0 5712.6 7259.0 True False 10491.60625285048 9445.537881323551 8215.478623376684 8308.875606299465 8250.82763240766 7125.330077869747 7914.485185403901 7281.125398042296 6855.279623380241 7049.4138088529735 1.4882948479595064 1.3399040171909637 1.165413018180223 1.178661918791716 1.1704274789551858 1.0107691605394813 1.1227153632922686 1.032869625116677 0.9724609462947217 1.0 12.783287580439962 -1.5228787452810233 0.3396009780282746 1.0020245725244012 6.420563533343073 0.9144580777160767 0.04529296907338095 15.917312285778289 0.22559594612265468 0.04020537255404312 54.664166155019394 0.02999999999995263 1.5228787452810233 5.4185389608186725 TAPAAAVS(ph)PMQR ddPTM_A459_Selumetinib_30min_R1 2 TAPAAAVSPMQR 12 0 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 TAPAAAVS(1)PMQR;TAPAAAVS(1)PMQR 165.51 0.00050849 30930000.0 5649.5 5767.7 6144.4 5860.9 6519.200000000001 4690.1 5034.8 5407.1 2834.5 4559.299999999999 True False 5781.122357986615 5092.415002669016 5310.024228773281 4837.403837718713 5929.539511058242 4642.921852270081 4655.020982459265 5263.686143263904 4809.939476310965 5144.530566342812 1.1237414732859385 0.9898697144468821 1.0321688558939046 0.9403003394258318 1.1525909768815863 0.9024966986581016 0.9048485420446177 1.0231616034513717 0.9349617840312097 1.0 12.328823723198724 -6.796422608042457 24.99999781339824 0.9515260204171097 1.0376865932624968 0.3283398248129138 0.0668938950182694 235.8987303276206 168578.24214206077 0.022979711440239657 0.020266981562330214 1.598002270197055e-07 6.796422608042457 0.08616057284538714 TAPAAAVS(ph)PMQR ddPTM_A459_Selumetinib_30min_R2 3 TAPAAAVSPMQR 12 0 Q5M775;Q5M775-4;J3KSG2 Q5M775 SPECC1 Cytospin-B 1 TAPAAAVS(1)PMQR;TAPAAAVS(1)PMQR;TAPAAAVS(1)PMQR 127.3 0.0026128 37134000.0 82593.0 69024.0 89617.0 93177.0 102517.0 89165.0 80158.0 67022.0 74219.0 81252.0 True False 78002.81170597524 74317.91885285907 83851.13978761202 80486.13186070966 89637.89794639163 101446.66939071906 83885.5058300637 67217.02292391057 89064.8738521266 78906.04364195092 0.9885530702809756 0.9418533159524356 1.0626706893086704 1.0200249327659698 1.136008014204061 1.2856641229035626 1.063106220490637 0.8518615282362756 1.1287459076806974 1.0 16.26784818420328 -1.5829609927205213 17.751341340284675 1.0499070063703164 0.005218732541953264 0.0 0.11295710215169802 0.0 0.0 0.02755865444758121 0.0 0.02612395982947997 1.5829609927205213 -1.0446882738283632 TAPAAPAEDAVAAAAAAPSEPSEPS(ph)RPSPQPKPR ddPTM_A459_Selumetinib_30min_R1 2 TAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPR 34 2 Q53GA4 Q53GA4 PHLDA2 Pleckstrin homology-like domain family A member 2 1 TAPAAPAEDAVAAAAAAPS(0.019)EPS(0.044)EPS(0.469)RPS(0.469)PQPKPR;TAPAAPAEDAVAAAAAAPS(0.002)EPS(0.007)EPS(0.496)RPS(0.496)PQPKPR 130.51 1.5431e-25 198516000.0 9923.5 10036.900000000001 12451.2 12182.400000000001 10532.0 10642.2 9173.8 9642.6 6256.5 7747.9 True False 10154.698242230317 8861.775081971777 10760.39542954591 10054.972531970256 9579.38245957562 10535.149130344484 8481.81288013125 9386.846924420952 10616.823543319648 8742.418435936976 1.1615433780300382 1.0136525890300754 1.2308259446051848 1.1501362701466948 1.0957359831003035 1.2050611861631135 0.9701906791907297 1.0737128396685933 1.2144034995714297 1.0 13.093816715748858 -7.242060236635946 24.97098404405931 1.0707194679889822 1.1391462131099492 0.17804880248192023 0.0817109663138598 1640.8882894837855 2114367.1934503363 0.03099548472088618 0.02396371685052279 5.7271658969717817e-08 7.242060236635946 0.06842674512096703 TAPAAPAEDAVAAAAAAPSEPSEPS(ph)RPSPQPKPR ddPTM_A459_Selumetinib_30min_R2 4 TAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPR 34 2 Q53GA4 Q53GA4 PHLDA2 Pleckstrin homology-like domain family A member 2 1 TAPAAPAEDAVAAAAAAPS(0.008)EPS(0.1)EPS(0.446)RPS(0.446)PQPKPR;TAPAAPAEDAVAAAAAAPS(0.001)EPS(0.038)EPS(0.481)RPS(0.481)PQPKPR;TAPAAPAEDAVAAAAAAPS(0.001)EPS(0.007)EPS(0.496)RPS(0.496)PQPKPR;TAPAAPAEDAVAAAAAAPS(0.002)EPS(0.062)EPS(0.468)RPS(0.468)PQPKPR 138.59 3.7026999999999987e-26 178169000.0 339765.0 319373.0 333935.0 346293.0 330881.0 263313.0 258401.0 263046.0 196723.0 313229.0 True False 320882.2214870594 343867.88215394923 312449.98566093727 299127.2960112544 289312.7706663286 299581.9756325732 270417.158511868 263811.4203103905 236073.09689987556 304185.2649033218 1.0548907475483544 1.1304554224979952 1.027170023374545 0.9833720778891938 0.9511071180856835 0.98486682360432 0.8889883558226063 0.8672721881983231 0.7760832760091317 1.0 18.214590743325047 -6.1888903599279015 0.6930274172115983 0.8727819979614504 1.1061625445072727 0.6094923435915218 0.060091484983620616 0.5385053313484913 0.541864627333666 0.03660727249102682 0.07383842205641429 6.473060111472594e-07 6.1888903599279015 0.2333805465458223 TAPAAPAEDAVAAAAAAPSEPSEPSRPS(ph)PQPK ddPTM_A459_Selumetinib_30min_R1 1 TAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPK 32 1 Q53GA4 Q53GA4 PHLDA2 Pleckstrin homology-like domain family A member 2 1 TAPAAPAEDAVAAAAAAPSEPS(0.052)EPS(0.099)RPS(0.849)PQPK 148.13 9.0289e-21 7101500.0 2039.7 3746.9 1768.1 1934.8 1928.6 2160.1 2193.2 2248.5 1357.4 2041.8 True False 2087.221041434692 3308.211206113449 1528.0017314781003 1596.9235006941203 1754.1584705219855 2138.371355213877 2027.7651582445499 2188.8624758426663 2303.4086594265314 2303.8849188162103 0.9059571614832023 1.435927280522885 0.6632283231678183 0.6931437797312623 0.7613915331427721 0.9281589274487816 0.880150367617521 0.950074570984802 0.9997932798701058 1.0 11.16985293928967 -5.2699556572405815 24.99220738813733 0.8514550589993872 1.1709422320801155 0.36462885109142806 0.16417673245286446 567.491003121568 1665384.3829970811 0.04289558516530302 0.09163163762114045 5.370866317146871e-06 5.2699556572405815 0.31948717308072827 TAPAAPAEDAVAAAAAAPSEPSEPSRPS(ph)PQPK ddPTM_A459_Selumetinib_30min_R2 3 TAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPK 32 1 Q53GA4 Q53GA4 PHLDA2 Pleckstrin homology-like domain family A member 2 1 TAPAAPAEDAVAAAAAAPSEPS(0.005)EPS(0.008)RPS(0.987)PQPK;TAPAAPAEDAVAAAAAAPSEPS(0.002)EPS(0.049)RPS(0.949)PQPK;TAPAAPAEDAVAAAAAAPS(0.001)EPS(0.009)EPS(0.056)RPS(0.934)PQPK 178.42 1.2291e-34 56409000.0 250184.0 187956.0 228014.0 232495.0 225525.0 192344.0 265720.0 267699.0 242485.0 220878.0 True False 236279.7748459036 202371.62082620498 213343.82748287215 200828.77992375483 197192.53328091936 218837.64007501205 278076.5065141914 268477.95977004495 290988.77559698926 214500.6782300357 1.1015339289161197 0.9434544566296279 0.9946067734763854 0.9362617478923829 0.9193096026924695 1.020218872409929 1.2963898706929748 1.2516415425135519 1.3565867390168616 1.0 17.71062268382859 -7.179845061243844 4.9412752945616365 1.2467418514781743 0.9757088303923839 0.5833494258054537 0.09907757409885969 0.13849207634739502 5.95650642253698 0.03677395683792096 0.028060382457201542 6.609291988349379e-08 7.179845061243844 -0.2710330210857904 TAPAAPAEDAVAAAAAAPSEPSEPSRPS(ph)PQPKPR ddPTM_A459_Selumetinib_30min_R2 3 TAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPR 34 2 Q53GA4 Q53GA4 PHLDA2 Pleckstrin homology-like domain family A member 2 1 TAPAAPAEDAVAAAAAAPSEPS(0.01)EPS(0.052)RPS(0.938)PQPKPR;TAPAAPAEDAVAAAAAAPSEPS(0.007)EPS(0.199)RPS(0.794)PQPKPR;TAPAAPAEDAVAAAAAAPSEPS(0.001)EPS(0.192)RPS(0.807)PQPKPR 180.09 1.1371999999999999e-41 31021100.0 39612.0 40586.2 40272.0 42937.0 40370.0 31009.4 32731.0 30951.7 25765.5 33698.8 True False 37410.52361939988 43699.03103479814 37680.94336483829 37088.906529543645 35298.35968762094 35280.663374693686 34253.05635524608 31041.764322670235 30919.319948220345 32725.82808400257 1.143149793593377 1.3353071134710148 1.1514129839011755 1.133322170926941 1.0786086022640908 1.078067857721834 1.046667368273259 0.9485402246504021 0.944798703606669 1.0 14.998142077680821 -6.43061603312209 0.6238509664537868 0.9604153873092165 1.2514623621117795 0.7497398508351716 0.05476236857023167 0.41254947518789864 0.3498218100603787 0.039393261296203755 0.062194864072265245 3.710085916074969e-07 6.43061603312209 0.29104697480256303 TAPPALPT(ph)GYDSEEEEESRPMSYDEK ddPTM_A459_Selumetinib_30min_R1 3 TAPPALPTGYDSEEEEESRPMSYDEK 26 1 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;A0A0G2JHN8;A0A140T9I1 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 TAPPALPT(0.809)GY(0.151)DS(0.04)EEEEESRPMSYDEK;T(0.001)APPALPT(0.67)GY(0.164)DS(0.164)EEEEES(0.002)RPMSYDEK;TAPPALPT(0.474)GY(0.422)DS(0.093)EEEEES(0.008)RPMS(0.002)Y(0.002)DEK 70.699 0.0010686 52377900.0 2269.03 2911.45 2016.47 1831.81 3375.94 2008.31 2826.13 2448.5899999999997 922.01 1703.04 True False 2321.89398423619 2570.5760805036157 1742.6444496768524 1511.9187708323836 3070.586823070618 1988.1082247995832 2612.9527387696835 2383.645439058747 1564.583629053968 1921.6417730143783 1.2082865895415862 1.3376978563862547 0.9068518774668693 0.7867849211358037 1.5978976238916527 1.0345883674671281 1.3597501758461892 1.2404213274983338 0.8141911000402995 1.0 10.908123702738363 -8.25709131980766 24.76755911998318 0.9070955393745503 1.1813469054669978 0.19578232425471898 0.22446171853820465 507.92831132718493 2893328.5001245234 0.1657954543006867 0.05772047310101397 5.532337676196181e-09 8.25709131980766 0.2742513660924475 TAPPALPT(ph)GYDSEEEEESRPMSYDEK ddPTM_A459_Selumetinib_30min_R2 3 TAPPALPTGYDSEEEEESRPMSYDEK 26 1 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;A0A0G2JHN8;A0A140T9I1 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 TAPPALPT(0.333)GY(0.333)DS(0.333)EEEEES(0.001)RPMS(0.001)YDEK;TAPPALPT(0.333)GY(0.333)DS(0.333)EEEEESRPMSYDEK;TAPPALPT(0.406)GY(0.28)DS(0.314)EEEEESRPMSYDEK 99.11 3.4503e-06 68070500.0 193755.0 164153.0 168096.0 188988.0 203361.0 179616.0 190787.0 191753.0 171832.0 175183.0 True False 182986.8727627192 176743.0072649132 157280.88636908637 163247.50837751545 177812.9731095934 204356.4736082922 199658.97353726823 192310.96948358172 206203.20138722716 170125.01160990345 1.0756024116095757 1.038900780034536 0.9245018406213623 0.9595738265214164 1.0451900718591483 1.2012135762663838 1.1736015277699798 1.1304097361330423 1.2120686983995685 1.0 17.37623573462045 -6.59989288008677 5.053059019311571 1.1527470735698502 0.9975046421119396 0.5084022752191442 0.06699027883676309 0.15800697059943147 7.273856733902584 0.02223215444414121 0.022292481765245033 2.512506071533408e-07 6.59989288008677 -0.1552424314579106 TAPPALPTGYDS(ph)EEEEESRPMSYDEKR ddPTM_A459_Selumetinib_30min_R1 2 TAPPALPTGYDSEEEEESRPMSYDEKR 27 2 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;A0A0G2JHN8;A0A140T9I1 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 TAPPALPT(0.133)GY(0.111)DS(0.689)EEEEES(0.023)RPMS(0.023)Y(0.021)DEKR;TAPPALPT(0.183)GY(0.141)DS(0.673)EEEEES(0.003)RPMS(0.001)Y(0.001)DEKR 66.041 0.0013577 19015000.0 811.19 735.73 990.13 1308.65 865.23 829.79 858.4200000000001 799.02 432.22 528.01 True False 830.0891486990281 649.5903895684022 855.6757843947798 1080.1188439029147 786.9700992687634 821.4430659890384 793.6686882820934 777.827394017259 733.445771900203 595.7852267529374 1.3932691034033524 1.0903096626089672 1.4362151761604771 1.8129332440645136 1.320895624683066 1.3787570236777247 1.3321389196030118 1.305549985279866 1.2310573323503222 1.0 9.218648540360292 -8.578100347449418 0.8274390373171406 1.001547519376606 1.407362092497163 0.35586304527286095 0.1659835924584697 0.8842828558241319 1.335494226459195 0.17304003883000021 0.062148899305788916 2.641798276740452e-09 8.578100347449418 0.40581457312055713 TAPPALPTGYDS(ph)EEEEESRPMSYDEKR ddPTM_A459_Selumetinib_30min_R2 2 TAPPALPTGYDSEEEEESRPMSYDEKR 27 2 H0Y6K2;A0A140T9E9;A0A0G2JK44;P25440-4;P25440-3;P25440;P25440-2;A0A0G2JHN8;A0A140T9I1 H0Y6K2 BRD2 Bromodomain-containing protein 2 1 TAPPALPT(0.046)GY(0.035)DS(0.918)EEEEESRPMSYDEKR;TAPPALPT(0.067)GY(0.055)DS(0.876)EEEEES(0.002)RPMSYDEKR 116.27 9.5066e-12 13134100.0 45840.0 54725.0 57675.0 58459.0 64667.0 39791.0 29641.0 33092.0 26082.2 53055.0 True False 43292.396312059245 58922.2315313907 53964.25329179203 50496.783352600105 56542.953329684955 45271.84906326584 31019.365232527238 33188.29224132449 31299.368797557712 51523.164296555275 0.8402511162334352 1.1436066153128355 1.0473784758479976 0.9800792331377871 1.0974278094458048 0.8786698115568305 0.6020469754921696 0.6441431285217741 0.6074814935163119 1.0 15.65293357887857 -7.030770644520645 4.177081687314947 0.6862130542016265 1.026339109177945 0.5488763704474988 0.13054371502187326 0.14332098315677216 5.627602357474082 0.04771375419982152 0.03823676178410716 9.315997331869051e-08 7.030770644520645 0.34012605497631854 TAPPAS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 4 TAPPASPEAR 10 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 TAPPAS(1)PEAR;TAPPAS(1)PEAR;TAPPAS(1)PEAR;TAPPAS(1)PEAR 155.33 0.00052713 535190000.0 15235.500000000002 17485.100000000002 18582.2 20288.0 16395.1 15260.1 16360.099999999999 15337.2 8809.2 12416.2 True False 15590.457506877598 15437.936363397534 16058.839304718265 16745.08165292656 14912.16609979001 15106.59724906221 15126.044485407921 14930.407633753233 14948.569001488286 14009.940214029704 1.1128139926867886 1.1019273549745643 1.146246098083757 1.1952286303233368 1.0643989818640915 1.0782770674448918 1.079665170181136 1.0657010241058533 1.066997344251236 1.0 13.774163178779501 -6.302317608416623 23.58293481869764 1.0644380557742752 1.136915828156794 0.605041424448989 0.03142661624739242 197.78291172567734 114101.57210409576 0.00991551800484261 0.011243346806523863 4.98519776430896e-07 6.302317608416623 0.07247777238251873 TAPPAS(ph)PEAR ddPTM_A459_Selumetinib_30min_R2 2 TAPPASPEAR 10 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 TAPPAS(1)PEAR;T(0.006)APPAS(0.994)PEAR 121.29 0.004823600000000001 340300000.0 1016890.0 922760.0 1148750.0 1117030.0 1069520.0 805360.0 773210.0 806580.0 770290.0 948200.0 True False 960375.3247332008 993532.724858949 1074840.6756644323 964888.5870157684 935157.335969886 916291.0296698197 809165.7970865488 808927.0142634929 924369.5237008675 920823.0022805313 1.042953230267612 1.0789616705907032 1.1672608883601487 1.0478545655637437 1.0155668718677249 0.9950783455675113 0.8787419461531154 0.8784826315807551 1.0038514691874039 1.0 19.81256434707025 -6.584813941993592 1.602964874868152 0.9331319095919062 1.0921238059063325 0.6012691855740471 0.05165367363462512 0.2440946941553553 1.2870226940280278 0.021458596141592685 0.022452267487084746 2.601273747592876e-07 6.584813941993592 0.15899189631442634 TAPQT(ph)PVLQK ddPTM_A459_Selumetinib_30min_R1 1 TAPQTPVLQK 10 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 T(0.009)APQT(0.991)PVLQK 108.72 0.024579 4556700.0 3329.2 3298.3 3370.5 4128.1 3258.1 2565.7 3054.3 3040.6 2125.9 2756.0 True False 3406.7638825044723 2912.133502661929 2912.804612831253 3407.204829034213 2963.4054302642735 2539.89138746921 2823.9116919689623 2959.953410739255 3607.4970304072963 3109.7594457133305 1.095507206256918 0.9364497651662992 0.9366655729099653 1.0956490006746016 0.952937190800787 0.816748507981973 0.9080804291346725 0.9518271308153509 1.1600566196141233 1.0 11.60258727019516 -8.236140473995075 24.149081965422166 1.080028311176651 0.95760414800051 0.23091777813769354 0.08609105471366184 629.2550678956911 600657.9688585933 0.060109630007709705 0.02269464735016718 5.805765977153621e-09 8.236140473995075 -0.12242416317614113 TAPQT(ph)PVLQK ddPTM_A459_Selumetinib_30min_R2 4 TAPQTPVLQK 10 0 Q15746-4;Q15746-5;Q15746-2;Q15746-3;Q15746-6;Q15746 Q15746-4 MYLK Myosin light chain kinase, smooth muscle;Myosin light chain kinase, smooth muscle, deglutamylated form 1 T(0.002)APQT(0.998)PVLQK;TAPQT(1)PVLQK;TAPQT(1)PVLQK;TAPQT(1)PVLQK 141.37 0.0030779 20031200.0 142061.0 129822.0 139662.0 166594.0 171759.0 116250.0 139401.0 131046.0 112282.0 141052.0 True False 134165.81833524094 139778.92995647687 130676.29897248792 143903.60980932022 150181.09887505783 132262.38228756897 145883.4227178412 131427.32216416686 134741.53742120558 136979.46226289164 0.9794593738275105 1.02043713449694 0.9539846106396106 1.050548800762115 1.0963767589248492 0.9655635969261609 1.0650021565850583 0.9594673536674492 0.9836623329898097 1.0 17.063600076289767 -10.61566414182654 14.229687106794875 0.9999999999715908 1.0098496108370791 0.0018289264587437737 0.04639733991914177 0.0 0.0 0.044871903443224316 0.010883035067087462 2.4229020543827128e-11 10.61566414182654 0.0098496108654883 TAPS(ph)PLVEAK ddPTM_A459_Selumetinib_30min_R1 2 TAPSPLVEAK 10 0 Q8TEH3;Q8TEH3-7;Q8TEH3-6;A0A0A0MS48;Q8TEH3-4;Q8TEH3-3;Q8TEH3-5;Q8TEH3-2 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 T(0.077)APS(0.923)PLVEAK;T(0.013)APS(0.987)PLVEAK 171.49 0.00017303 41930600.0 10747.5 13265.1 10192.1 12338.7 10965.0 10549.4 12069.4 10202.900000000001 5804.200000000001 9935.9 True False 10997.89583900542 11712.015925222311 8808.06880119786 10183.977671084633 9973.217686027989 10443.28261408882 11158.995440870307 9932.285948310055 9849.303478004622 11211.269548861783 0.9809679261633643 1.0446645559789762 0.7856441915708016 0.9083697102009785 0.8895707700686327 0.931498664676122 0.9953373605224947 0.885919824246704 0.878518122776253 1.0 13.452662035760657 -5.215033399443497 24.99996012548045 0.908402444779952 1.0128162951257624 0.32637254962270623 0.05944127236821211 481.53246575815024 259410.86807313762 0.014973870332497202 0.0396168765012558 6.094900225705544e-06 5.215033399443497 0.10441385034581041 TAPS(ph)PLVEAK ddPTM_A459_Selumetinib_30min_R2 3 TAPSPLVEAK 10 0 Q8TEH3;Q8TEH3-7;Q8TEH3-6;A0A0A0MS48;Q8TEH3-4;Q8TEH3-3;Q8TEH3-5;Q8TEH3-2 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 T(0.03)APS(0.97)PLVEAK;T(0.064)APS(0.936)PLVEAK;T(0.042)APS(0.958)PLVEAK 145.09 0.00091454 54397000.0 325559.0 245882.0 300837.0 293230.0 296683.0 240517.0 242982.0 256544.0 180303.0 221764.0 True False 307465.73409593577 264740.3587647582 281481.4749465598 253291.5681500362 259411.02916032774 273646.0335540576 254281.14445969864 257290.5005668544 216368.63808674287 215361.09710793121 1.4276753704585978 1.229285893877481 1.3070209927723921 1.1761249898494694 1.2045398757897314 1.2706381850242714 1.1807199530204013 1.19469348931627 1.0046783796718248 1.0 17.716398138996844 -1.5228787459398847 0.07838513691162599 0.7767777022666961 2.3080313312904357 0.7164516672111605 0.064840867352665 113.1174604097003 0.6503090635314738 1.9643331838408982 18.807372502133667 0.0299999999544401 1.5228787459398847 1.5312536290237397 TAPSS(ph)PLTSPSDTR ddPTM_A459_Selumetinib_30min_R1 2 TAPSSPLTSPSDTR 14 0 A0A087WVA8;Q8IWB9;Q8IWB9-2 A0A087WVA8 TEX2 Testis-expressed sequence 2 protein 1 T(0.001)APS(0.052)S(0.918)PLT(0.02)S(0.005)PS(0.004)DT(0.001)R;TAPS(0.253)S(0.717)PLT(0.028)SPS(0.002)DTR 156.52 0.00032024 8602300.0 5768.0 6994.2 7845.5 7485.299999999999 6956.8 6821.200000000001 7150.4 6941.7 3925.6000000000004 5497.4 True False 5902.38317742575 6175.315812484638 6780.124192246722 6178.132871483198 6327.5586683227975 6752.584921154063 6611.039571179931 6757.583566180584 6661.456485519962 6203.044839210616 0.951529987356479 0.9955297716774997 1.0930316268856026 0.9959839130018946 1.0200730177420458 1.0885919892872127 1.0657733004588816 1.0893978266068018 1.073901069263862 1.0 12.59876083824707 -6.685924259710391 6.755608904442182 1.0691538834229992 1.0135463407635679 0.288964736014121 0.04052563821376364 0.280639057221994 20.33543879226297 0.013569179334461624 0.013507462096462766 2.0609893152958682e-07 6.685924259710391 -0.05560754265943135 TAPTALGITLSS(ph)SPTSTPELR ddPTM_A459_Selumetinib_30min_R1 1 TAPTALGITLSSSPTSTPELR 21 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 TAPTALGITLSS(0.623)S(0.36)PT(0.013)S(0.004)T(0.001)PELR 266.39 3.590799999999998e-50 139480000.0 4447.6 5055.1 5136.0 5937.8 5547.3 4625.3 4800.3 4661.5 2670.3 4203.6 True False 4551.2204264769 4463.2465419477685 4438.559410028572 4900.874696310493 5045.54769445536 4578.773681436387 4438.209506256297 4537.86187731403 4531.304069004469 4743.173006531407 0.9595307656309002 0.9409832902577713 0.9357785187081773 1.033248142026852 1.0637494536900889 0.9653397999886068 0.9357047487293482 0.9567143916246231 0.9553318132745334 1.0 12.211636776126726 -5.697485401746798 24.9999848141387 0.9854918729975444 0.9449859132857666 0.2115616706505249 0.03681088760300672 118.32806145226293 46253.352383317295 0.011461673073887265 0.019852194134134086 2.0068485465299908e-06 5.697485401746798 -0.04050595971177773 TAPTALGITLSS(ph)SPTSTPELR ddPTM_A459_Selumetinib_30min_R2 3 TAPTALGITLSSSPTSTPELR 21 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 TAPTALGITLSS(0.569)S(0.428)PT(0.002)S(0.001)TPELR;TAPTALGITLS(0.001)S(0.837)S(0.161)PT(0.001)STPELR;TAPTALGITLSS(0.702)S(0.293)PT(0.004)S(0.001)TPELR 267.69 8.442099999999997e-60 95262000.0 103368.0 88590.0 101807.0 112658.0 106773.0 80565.0 102187.0 86275.0 76603.0 89908.0 True False 97623.22037488972 95384.56813825296 95256.84845908034 97313.78605411021 93359.22117726898 91662.09745374609 106938.89797969916 86526.0459664049 91925.74046665205 87312.12243096181 1.1180946889944285 1.0924550392607175 1.0909922449130758 1.1145506871747022 1.0692584096909183 1.0498209744726321 1.2247886662502834 0.9909969378515742 1.0528405209636067 1.0 16.413894351352504 TAPTALGITLSSS(ph)PTSTPELR ddPTM_A459_Selumetinib_30min_R1 4 TAPTALGITLSSSPTSTPELR 21 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 TAPTALGITLSS(0.222)S(0.755)PT(0.017)S(0.005)TPELR;TAPTALGITLS(0.021)S(0.226)S(0.657)PT(0.035)S(0.046)T(0.016)PELR;TAPTALGITLSS(0.228)S(0.765)PT(0.005)S(0.001)TPELR;TAPTALGITLSS(0.116)S(0.707)PT(0.129)S(0.038)T(0.011)PELR 284.46 2.411799999999999e-73 195681500.0 7451.4 7430.4 8467.6 8266.199999999999 8102.0 7478.4 7767.999999999999 6485.2 4014.31 5960.0 True False 7625.003122099555 6560.445313700758 7317.746429197419 6822.663345791675 7369.175530524275 7403.174085843921 7182.053505947317 6313.191429101558 6811.99087639791 6725.024055316199 1.1338254048432606 0.9755274122052633 1.0881368407021037 1.0145188016685667 1.0957842633587114 1.100839792534517 1.0679595265194377 0.9387611668260006 1.0129318230487165 1.0 12.715323712840393 -7.742901113148496 24.913452199844624 0.9818848783538675 1.0655609139378766 0.41158956369406663 0.04603973759809509 211.0707012430813 283657.1552457658 0.02084050735859956 0.012003414140992869 1.807585658078848e-08 7.742901113148496 0.08367603558400905 TAPTALGITLSSS(ph)PTSTPELR ddPTM_A459_Selumetinib_30min_R2 1 TAPTALGITLSSSPTSTPELR 21 0 F5H1U9;O75970-5;O75970-3;O75970-2;O75970 F5H1U9 MPDZ Multiple PDZ domain protein 1 TAPTALGITLSS(0.329)S(0.666)PT(0.003)S(0.001)TPELR 235.79 4.0174e-26 39795000.0 24573.0 24430.0 26613.0 31683.0 30967.0 19401.0 18970.0 22276.0 19922.0 22002.0 True False 23207.331033512895 26303.70244516901 24900.748554043534 27367.720743776477 27076.6486115075 22073.31164525699 19852.142588341885 22340.819472009673 23906.95666718851 21366.745091938727 1.0861425515984926 1.2310579983983103 1.1653973708629173 1.2808558639145187 1.267233193216828 1.0330685160644724 0.9291140275657488 1.0455883371978096 1.1188862208221018 1.0 14.383079531001956 -6.775947660984486 23.048500259986046 1.022166914005827 1.2094095325470944 0.6434929459045999 0.06724646974773912 60.47322661149589 96069.14423327366 0.02442672639601777 0.021662858665696654 1.6751447439927722e-07 6.775947660984486 0.18724261854126745 TAPTLS(ph)PEHWK ddPTM_A459_Selumetinib_30min_R1 4 TAPTLSPEHWK 11 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 T(0.088)APT(0.208)LS(0.704)PEHWK;TAPT(0.008)LS(0.992)PEHWK;T(0.006)APT(0.042)LS(0.951)PEHWK;T(0.001)APT(0.099)LS(0.9)PEHWK 141.58 0.00099208 172673000.0 13068.4 13552.2 15001.5 15982.6 13675.400000000001 11787.499999999998 13761.800000000001 12950.399999999998 7565.3 10950.3 True False 13372.868293320156 11965.50212375315 12964.378697341059 13191.538940559147 12438.462484587964 11668.928452193677 12723.736346311256 12606.913323172275 12837.761552349746 12355.877669954529 1.0823082463691445 0.9684056805490519 1.049247899958269 1.0676326921426775 1.0066838485164236 0.9444030415232024 1.0297719584300546 1.02031710412836 1.0390003766035174 1.0 13.592909872216858 -6.456445241161099 22.09073261820268 1.005647440096424 1.0371722829893937 0.1754424149611833 0.03678605387347888 120.38920834640025 40031.15841959159 0.011660240477801221 0.0132214350606126 3.4958658510383014e-07 6.456445241161099 0.03152484289296975 TAPTLS(ph)PEHWK ddPTM_A459_Selumetinib_30min_R2 4 TAPTLSPEHWK 11 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 TAPT(0.078)LS(0.922)PEHWK;T(0.002)APT(0.03)LS(0.968)PEHWK;T(0.034)APT(0.148)LS(0.818)PEHWK;TAPTLS(0.999)PEHWK 150.14 0.00061878 222885600.0 307004.0 303471.0 336213.0 375199.0 349288.0 277781.0 276893.0 275713.0 252693.0 296442.0 True False 289941.9467143857 326746.2498869371 314581.421621036 324096.24894562416 305407.31876566075 316042.8113051453 289769.0731530703 276515.27918325574 303238.6608323395 287882.94921118586 1.0071522037301675 1.1349968825254801 1.092740721473798 1.1257917491593878 1.0608732458886245 1.0978170543657377 1.0065517042501215 0.9605128749060057 1.053340121960085 1.0 18.135122817638504 -7.27350338014175 10.792456733260039 1.0017754765393878 1.089664988242931 0.5058069669885357 0.03932019736894113 0.35651334176114147 311.0267240317994 0.01538893251775231 0.010721110279000887 5.32717078135711e-08 7.27350338014175 0.0878895117035432 TAPTSTIAPGVVMAS(ph)SPALPTQPAEEAAR ddPTM_A459_Selumetinib_30min_R2 3 TAPTSTIAPGVVMASSPALPTQPAEEAAR 29 0 C9JBT4;C9J896;P16220;P16220-1;H7C1R5 C9JBT4 CREB1 Cyclic AMP-responsive element-binding protein 1 1 TAPTSTIAPGVVMAS(0.818)S(0.182)PALPTQPAEEAAR;TAPTSTIAPGVVMAS(0.493)S(0.493)PALPT(0.014)QPAEEAAR;TAPTSTIAPGVVMAS(0.483)S(0.483)PALPT(0.034)QPAEEAAR 125.94 8.2111e-14 8335400.0 48089.3 41114.0 49365.0 50995.6 53756.8 42398.0 39444.1 40679.7 37995.0 48400.2 True False 45416.68922272058 44267.31159765368 46188.9096445481 44049.91130768326 47003.39019211046 48237.9396492761 41278.32880700137 40798.07119211313 45595.06166900047 47002.760467178094 0.9662557852199966 0.9418023783638289 0.982685042015813 0.9371771119367169 1.0000133976159296 1.0262788646841399 0.878210734789203 0.8679930877805 0.9700507207622281 1.0 15.52045786815589 -7.269425182891449 24.992329218806567 0.9180630629688088 0.9738325308400827 0.1951037422715335 0.044105523438595036 852.7680062926063 2668806.4296296746 0.018209589876505616 0.01251031765291854 5.377430636242927e-08 7.269425182891449 0.0557694678712739 TAPTSTIAPGVVMASS(ph)PALPTQPAEEAAR ddPTM_A459_Selumetinib_30min_R1 1 TAPTSTIAPGVVMASSPALPTQPAEEAAR 29 0 C9JBT4;C9J896;P16220;P16220-1;H7C1R5 C9JBT4 CREB1 Cyclic AMP-responsive element-binding protein 1 1 TAPTSTIAPGVVMAS(0.285)S(0.709)PALPT(0.006)QPAEEAAR 86.00399999999998 2.7588e-06 7497000.0 1848.8 2147.9 2177.9 2184.3 2146.4 1992.7 2002.0 2076.6 1270.1 1689.5 True False 1891.8734428614293 1896.42286946838 1882.15314234837 1802.8530093891702 1952.2584989776974 1972.655247226837 1850.987528180552 2021.521822252561 2155.2669355662583 1906.3637821236111 0.9923989642490794 0.9947854062543313 0.9873000945557875 0.9457025077243473 1.0240744800569812 1.034773774934698 0.9709518957177353 1.0604071695071067 1.1305643528148543 1.0 10.89660773265467 -7.852136254754976 5.883534063332766 1.0743310401329105 0.9938450986421258 0.4201725711947676 0.03771838263743795 0.18166940161413936 9.406639484982934 0.02051311272398366 0.009715281690586197 1.4056064625485983e-08 7.852136254754976 -0.0804859414907847 TAQALSSGS(ph)GSQETK ddPTM_A459_Selumetinib_30min_R2 1 TAQALSSGSGSQETK 15 0 C9JIG9;O95747 C9JIG9 OXSR1 Serine/threonine-protein kinase OSR1 1 TAQALS(0.017)S(0.017)GS(0.957)GS(0.009)QETK 112.57 0.0029751 3672600.0 20933.0 20146.0 22642.0 22522.0 23269.0 16081.0 20514.0 21017.0 15386.0 15903.0 True False 19769.627661438386 21691.13342040012 21185.238370745647 19454.464747382954 20345.740192500652 18296.011781216297 21467.941647719843 21078.155990448362 18463.62992075909 15443.839069043797 1.280098010155089 1.4045169289466783 1.3717598503865611 1.2596909784159953 1.3174017225601895 1.1846802922137087 1.390065096621667 1.3648261870779397 1.195533690697948 1.0 13.914743805563063 -8.57335894213197 3.5203655712248016 1.0003283558438854 1.320832847160615 0.7093540643682366 0.06369036070278648 0.1441323817619354 4.976636112804624 0.06333384792509893 0.016698051869836597 2.6707980954653782e-09 8.57335894213197 0.32050449131672964 TAQALSSGSGS(ph)QETK ddPTM_A459_Selumetinib_30min_R1 2 TAQALSSGSGSQETK 15 0 C9JIG9;O95747 C9JIG9 OXSR1 Serine/threonine-protein kinase OSR1 1 TAQALSS(0.013)GS(0.008)GS(0.976)QET(0.003)K;TAQALSS(0.002)GS(0.005)GS(0.991)QET(0.002)K 122.5 0.0015509 16236000.0 1913.73 2203.73 1921.52 2198.76 1548.34 1756.58 1973.64 1718.76 1203.94 2077.2400000000002 True False 1958.3161855296428 1945.7162671137173 1660.5881381538372 1814.787841836987 1408.2929203816298 1738.9104000470304 1824.7667458133208 1673.1729014806947 2042.9982477014717 2343.873988031045 0.8355040396923014 0.8301283588834069 0.7084801259084763 0.7742685191713258 0.6008398606636086 0.741895856571961 0.7785259596426527 0.7138493408880876 0.8716331415997658 1.0 11.194679293957435 -8.519361214407644 3.199794938610021 0.9994505188279931 0.7464500425517367 0.611626144276351 0.06390806562373129 0.1539309747127893 3.983353187722805 0.06453787213925492 0.01714042565206232 3.0243969094208823e-09 8.519361214407644 -0.2530004762762563 TAQALSSGSGS(ph)QETK ddPTM_A459_Selumetinib_30min_R2 2 TAQALSSGSGSQETK 15 0 C9JIG9;O95747 C9JIG9 OXSR1 Serine/threonine-protein kinase OSR1 1 TAQALSS(0.012)GS(0.035)GS(0.947)QET(0.007)K;TAQALS(0.001)SGS(0.187)GS(0.811)QET(0.001)K 205.98 2.1448e-06 7040300.0 32086.0 22962.0 29827.0 27924.0 26245.0 20152.4 28382.0 27946.0 19883.6 24635.0 True False 30302.788570434837 24723.111565533 27907.96329318215 24120.703028413183 22947.868466723092 22928.210174726923 29701.819237866086 28027.318233290647 23860.875594202877 23923.723540583152 1.2666418134714907 1.033414030370055 1.1665392824758365 1.0082336467187427 0.9592097328743721 0.958388025836886 1.2415215878699328 1.1715282608807251 0.997372986430241 1.0 14.54615433076868 -4.755718077827329 24.93398826789595 1.066063845805672 1.2666421467085849 0.30152944644660873 0.09407899766162989 255.3930480812812 1112909.7742728693 0.024843826520058034 0.21490452949877642 1.7550194026236422e-05 4.755718077827329 0.20057830090291295 TAQDLSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TAQDLSSPR 9 0 Q9UHI6;Q9UHI6-2 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 TAQDLS(0.011)S(0.989)PR 93.561 0.024405 7208100.0 3915.8 4515.0 5089.9 4855.0 4904.7 4132.2 4657.8 4410.9 2581.9 3320.7 True False 4007.0305211795703 3986.3817010334474 4398.719536819397 4007.165389637148 4461.070750995114 4090.6338197374116 4306.458395983705 4293.908603377549 4381.295725485021 3746.9441913571313 1.0694129179778993 1.0639020752507105 1.1739485063497022 1.069448912231 1.1905890568867343 1.091725312902458 1.1493254705840492 1.145976129903955 1.1692983673445452 1.0 11.871498774351554 -5.232076422806899 24.038364923399538 1.1292142919270292 1.0666574472912824 0.14356697117500505 0.05454265038241457 706.5823731382554 578448.214271863 0.012612180885954288 0.03335410406065652 5.860350308463645e-06 5.232076422806899 -0.06255684463574673 TAQSPAMVGS(ph)PIR ddPTM_A459_Selumetinib_30min_R1 2 TAQSPAMVGSPIR 13 0 Q5VWG9 Q5VWG9 TAF3 Transcription initiation factor TFIID subunit 3 1 TAQSPAMVGS(1)PIR;TAQSPAMVGS(1)PIR 106.35 0.0069877 16301500.0 4058.5 4951.700000000001 4267.6 4717.1 5738.9 4017.2 5030.0 4119.9 2012.5100000000002 3678.8999999999996 True False 4153.055153533706 4371.952662017125 3688.08336024882 3893.347035933553 5219.817508285088 3976.7906153257627 4650.583050323769 4010.6268686787644 3415.0824820852313 4151.122650520601 1.0004655374403024 1.0531976600279032 0.8884544425075683 0.9379021926623343 1.2574471890466687 0.9580036414551675 1.1203193549919634 0.9661547504928053 0.8226888891507309 1.0 12.01928584360523 -7.999159554077474 24.992707780553012 0.9057035558061007 1.0296017669756123 0.1746320702855787 0.1052567471253175 43.59002951927469 1296275.6429731513 0.05821579320974118 0.027582407287576986 1.0019370719572823e-08 7.999159554077474 0.12389821116951161 TAQSPAMVGS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 2 TAQSPAMVGSPIR 13 0 Q5VWG9 Q5VWG9 TAF3 Transcription initiation factor TFIID subunit 3 1 TAQSPAMVGS(1)PIR;TAQSPAMVGS(1)PIR 161.08 0.00036377 34777000.0 112133.0 96050.0 114201.0 112463.0 101979.0 82161.0 85647.0 93624.0 70175.0 84260.0 True False 105901.09676396461 103416.72615057243 106853.43199264727 97145.34539050386 89167.48631617283 93477.93196670058 89629.75520631082 93896.43033971237 84211.96085332565 81827.19486622837 1.2942041693729378 1.2638429842259504 1.3058425400911269 1.1872012177530673 1.0897047914442677 1.1423822131446508 1.0953541222186356 1.1474966298577738 1.0291439293623095 1.0 16.32029277501875 -5.0103002591098535 0.24394515087363056 0.9956732889347134 1.551757240658958 0.838972729314728 0.04070860666342592 3.7886197463424716 0.21448418023008392 0.06756033605763359 0.6354155624402121 9.765618198605798e-06 5.0103002591098535 0.5560839517242445 TAQVPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 TAQVPSPPR 9 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 TAQVPS(1)PPR;TAQVPS(1)PPR 122.46 0.0059377 942170000.0 6411.5 7691.099999999999 6987.599999999999 7170.3 6951.1 6221.1 7860.099999999999 6907.5 3877.9 6599.6 True False 6560.875475392717 6790.622436504611 6038.722300139344 5918.141708200877 6322.374232316383 6158.521382306862 7267.206328797181 6724.290661277839 6580.513069390119 7446.722945547787 0.8810419728741625 0.9118940621477744 0.8109234550950694 0.7947310181237759 0.8490142950861863 0.827010945262693 0.9758932059023446 0.9029865499827849 0.8836790515114364 1.0 12.862389967911279 -7.251070655120208 24.953055723053367 0.9325552484292273 0.8450186374613828 0.5225874132503319 0.04414944856835058 633.4920146644048 1524544.464190307 0.01785818539729077 0.013670191726582499 5.6095670688345516e-08 7.251070655120208 -0.08753661096784449 TAQVPS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 TAQVPSPPR 9 0 S4R3H4;E7EQT4;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 TAQVPS(1)PPR;TAQVPS(1)PPR 103.43 0.015246 602820000.0 1395860.0 1549570.0 1492900.0 1778570.0 1674200.0 1377000.0 1267760.0 1487070.0 1142050.0 1540790.0 True False 1318283.6892703106 1668417.0363471357 1396848.4393466185 1536325.6977956202 1463872.0284620991 1566669.2508385591 1326713.3520187815 1491397.12750231 1370491.911543153 1496303.3892468063 0.8810270021067683 1.1150259020578481 0.9335328980640414 1.0267474556540035 0.9783256784568054 1.0470264667562992 0.886660660901536 0.9967210782387081 0.9159184704066046 1.0 20.51297129387136 -7.250149757005314 24.97266731230467 0.9495518051882716 0.9999403665399477 0.10481364491901246 0.06712257279218205 1540.7610118749644 3408171.729962138 0.023625387658678564 0.018138677307407747 5.621474474455842e-08 7.250149757005314 0.05038856135167602 TAQYS(ph)SPELK ddPTM_A459_Selumetinib_30min_R2 1 TAQYSSPELK 10 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 TAQYS(0.5)S(0.5)PELK 124.21 0.0039135 9372500.0 56432.0 60449.0 63469.0 69869.0 57168.0 51670.0 54795.0 49934.0 39985.0 58499.0 True False 53295.73535519476 65085.243925829775 59385.473639822216 60352.721669252234 49986.04475159554 58787.073486440306 57343.07607423267 50079.29967298129 47983.11727424621 56809.98187134458 0.9381403337866152 1.1456656344870144 1.0453351978585428 1.0623612203561474 0.8798813712843114 1.0348018349939483 1.009383812233832 0.881522894803839 0.8446247594817362 1.0 15.79385682215015 -6.711089734587539 0.757321024089922 0.9162750727629108 1.0565713917636785 0.2502910666939545 0.0785929253445906 0.8792652964229418 1.1128822805070742 0.05478051912030886 0.05672504383487496 1.9449581698819e-07 6.711089734587539 0.14029631900076778 TAQYSS(ph)PELK ddPTM_A459_Selumetinib_30min_R2 1 TAQYSSPELK 10 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 TAQYS(0.13)S(0.87)PELK 132.86 0.0023684 9621100.0 71138.0 63151.0 67257.0 71988.0 63424.0 64234.0 70685.0 66985.0 50209.0 63612.0 True False 67184.43474797717 67994.4786375304 62929.757843884836 62183.11021377344 55456.11010224594 73081.65044180385 73971.99255967038 67179.91526003623 60252.202956674446 61775.35627617519 1.0875604577271873 1.1006731929404303 1.0186870887890753 1.0066005922454795 0.89770603433385 1.1830227269767952 1.1974353046054234 1.0874872976806353 0.9753436740584501 1.0 15.914743805563063 -6.785879842997117 24.999591607441204 1.1009242905827221 1.0255355749364732 0.12994264333345196 0.08272237913639023 465.64883291302124 476298.14549655846 0.03102610474026387 0.027375731680953693 1.6372694449287765e-07 6.785879842997117 -0.07538871564624894 TARPFGIQAPGGTSQMERS(ph)PMLER ddPTM_A459_Selumetinib_30min_R1 1 TARPFGIQAPGGTSQMERSPMLER 24 2 Q8N3V7-2;Q8N3V7-3;Q8N3V7 Q8N3V7-2 SYNPO Synaptopodin 1 TARPFGIQAPGGT(0.009)S(0.059)QMERS(0.932)PMLER 75.695 0.00046638 29401000.0 387.06 436.2 946.1 998.55 820.41 661.35 483.32 441.09 442.2 324.75 True False 396.0777449123458 385.1295012161217 817.624816555302 824.1719876049792 746.2040603551495 654.6974194577548 446.86278327683556 429.3908603377546 750.3811029898424 366.43482583287505 1.0808954744192092 1.0510177364849405 2.231296697023572 2.249163915388519 2.036389578035034 1.786668114772343 1.2194877554587085 1.171806908259295 2.047788720093103 1.0 8.51741281293875 -7.2474093013162 22.158424888236247 1.3740881082233163 1.7670074900860642 0.135885464727044 0.46508247521537044 393.578305510641 621598.8688879252 0.194411560523143 0.14951409319935804 5.657058875840901e-08 7.2474093013162 0.3929193818627479 TAS(ph)APNLDR ddPTM_A459_Selumetinib_30min_R1 1 TASAPNLDR 9 0 Q86W92-2 Q86W92-2 PPFIBP1 Liprin-beta-1 1 T(0.206)AS(0.794)APNLDR 101.35 0.017103 9583800.0 3309.9 3157.6 3546.0 3430.4 3361.4 2888.3 3226.2 3311.4 1915.4 2692.1 True False 3387.0142300557386 2787.906724071584 3064.4726767837483 2831.3450365831663 3057.361963503372 2859.246324366574 2982.845136571479 3223.570915056887 3250.293904719007 3037.657258274621 1.115008686654646 0.917781858528406 1.008827664291645 0.9320817972042575 1.006486809917437 0.9412669308158275 0.9819557912421379 1.061202973533579 1.0700002101504904 1.0 11.568743383046415 -7.754813164535923 24.541615608850822 1.0492011978404174 0.9814105145816755 0.18099988517756738 0.055063713964819655 165.5027566727914 612982.7076411494 0.02484426694091668 0.013900670265396533 1.7586800434017803e-08 7.754813164535923 -0.06779068325874194 TAS(ph)EGDGGAAAGAAAAGAR ddPTM_A459_Selumetinib_30min_R2 1 TASEGDGGAAAGAAAAGAR 19 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 T(0.47)AS(0.53)EGDGGAAAGAAAAGAR 82.12100000000002 0.021555 0.0 15225.0 15578.0 15777.0 18474.0 12260.0 12161.0 12165.0 14622.0 10256.0 14769.0 True False 14378.855450503977 16772.782508835156 14761.92499669879 15957.809330572449 10719.78919420937 13836.06736343333 12730.696604490191 14664.547599197595 12307.486576582949 14342.580595529635 1.0025291721202285 1.1694396553757542 1.029237723182107 1.1126177206594368 0.7474100719050912 0.9646846515016847 0.8876154831201127 1.0224483314926125 0.8581082389328881 1.0 13.808017004525158 -6.220367129209062 24.998703903468275 0.9157773408660825 1.081439343498323 0.4792173339097089 0.0842605710457869 426.60027185913077 259650.93273303157 0.02349273965431205 0.03032865065091384 6.020504298284715e-07 6.220367129209062 0.1656620026322404 TAS(ph)EINFDK ddPTM_A459_Selumetinib_30min_R1 3 TASEINFDK 9 0 Q9Y4K4 Q9Y4K4 MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 1 T(0.027)AS(0.973)EINFDK;T(0.166)AS(0.834)EINFDK;T(0.008)AS(0.992)EINFDK 129.34 0.0041064 54306000.0 7190.599999999999 8223.800000000001 5844.8 6450.9 5367.200000000001 5851.700000000001 5806.200000000001 5792.6 3778.2000000000003 5339.349999999999 True False 7358.126989528014 7260.953672859103 5051.108263188279 5324.371413390375 4881.7377076561215 5792.837210918494 5368.233659401565 5638.961430983429 6411.329451190015 6024.70758217325 1.2213251662703553 1.205196032143341 0.8383989088755456 0.8837559899412998 0.8102862489294738 0.9615134231674834 0.8910363841202598 0.9359726350319107 1.0641727193799009 1.0 12.556675504430183 -5.251008395453099 24.555907715836298 0.9156419154419438 1.2132606752444028 0.7265592330310686 0.07107302115501858 274.31649440726915 645772.8852090051 0.01847927470113603 0.04770815819151037 5.610371303813322e-06 5.251008395453099 0.297618759802459 TAS(ph)ELLLDR ddPTM_A459_Selumetinib_30min_R2 2 TASELLLDR 9 0 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 T(0.438)AS(0.562)ELLLDR;T(0.006)AS(0.994)ELLLDR 143.97 0.0019868 5510200.0 39926.0 12509.7 23667.0 25402.0 16854.4 13023.2 39242.0 25665.0 21512.7 16135.1 True False 37707.07275644149 13469.153764974657 22144.29098668125 21942.20377910584 14736.99959175224 14817.027587161017 41066.83075654783 25739.680900930514 25815.84111506004 15669.237738975566 2.406439508071867 0.859592150514863 1.4132334549752652 1.4003363880635327 0.9405052011621163 0.9456125329125127 2.620856958114717 1.64268877208403 1.6475492646873227 1.0 13.935647378316665 TAS(ph)ESISNLSEAGS(ph)IK ddPTM_A459_Selumetinib_30min_R2 1 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 2 T(0.332)AS(0.638)ES(0.022)IS(0.007)NLS(0.004)EAGS(0.998)IK 137.13 0.0074262 3443300.0 64239.0 51551.0 52208.0 48733.0 47104.0 46926.0 46715.0 54758.0 33847.0 51641.0 True False 60668.85354909192 55504.79593740924 48848.994119772484 42095.48133088595 41186.37440489708 53389.63054818458 48887.34006401641 54917.33671432512 40617.345764196834 50149.99015056848 1.2097480650931731 1.1067758093424083 0.9740579005720652 0.8393916171169731 0.8212638583026761 1.0645990236067748 0.9748225257320862 1.0950617647070984 0.8099173228598612 1.0 15.613961797042391 -5.1094010212851595 2.5556296192676164 0.9463865564449633 1.202977458341766 0.47067189525846753 0.09280060932263431 0.2863451166718187 3.3805594719668837 0.025782129958806254 0.11398539996855843 7.77318454857356e-06 5.1094010212851595 0.2565909018968028 TAS(ph)ESISNLSEAGSIK ddPTM_A459_Selumetinib_30min_R1 1 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 TAS(0.718)ES(0.141)IS(0.141)NLSEAGSIK 252.25 1.4018e-29 61660000.0 1278.1 1957.6 1514.7 1725.1 1367.5 1406.0 1527.5 1273.2 618.15 1202.6 True False 1307.877243250321 1728.40328193645 1309.012059651535 1423.8436691375994 1243.8098664517345 1391.856916545858 1412.2794452026947 1239.4306000635456 1048.955402110292 1356.9654243159832 0.9638250318055035 1.2737268400244615 0.9646613216481765 1.049285150250109 0.9166113182866925 1.0257128822920913 1.0407630289582315 0.913384068491145 0.7730155708566028 1.0 10.406168245799574 -6.2482046220286875 0.5470918845484328 0.9106294728807969 1.1192365586964623 0.23617284018368978 0.10617563702292818 1.5909830533671336 0.9537481380545149 0.08140083207112037 0.1736930479700253 5.646708620103358e-07 6.2482046220286875 0.20860708581566545 TAS(ph)ESISNLSEAGSIK ddPTM_A459_Selumetinib_30min_R2 2 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 T(0.002)AS(0.985)ES(0.012)ISNLSEAGSIK;T(0.014)AS(0.984)ES(0.001)IS(0.001)NLSEAGSIK 270.95 1.5859e-50 55391000.0 106168.0 117299.0 109099.0 126714.0 109259.0 97609.0 80121.0 95582.0 69895.0 120990.0 True False 100267.60758417775 126295.4561242686 102079.68911800983 109455.33460615769 95532.90763214708 111053.7537437188 83846.78525674954 95860.12779554816 83875.95302947202 117496.7043302273 0.8533652765474447 1.074885094387943 0.8687876796196123 0.9315608912615188 0.8130688275617464 0.9451648399566984 0.7136096772646163 0.8158537581286619 0.7138579205910035 1.0 16.842260765583525 -6.300467945823031 1.0028865937783484 0.8084855126454266 0.9550507892771122 0.1705418482963741 0.10121821968863616 0.7702743251555624 1.6406470912514977 0.04482767972606172 0.06677279560010603 5.006475026907693e-07 6.300467945823031 0.14656527663168561 TAS(ph)FSESR ddPTM_A459_Selumetinib_30min_R1 5 TASFSESR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 T(0.002)AS(0.993)FS(0.006)ESR;T(0.015)AS(0.953)FS(0.032)ESR;T(0.021)AS(0.973)FS(0.003)ES(0.003)R;T(0.001)AS(0.982)FS(0.016)ESR;T(0.015)AS(0.978)FS(0.006)ES(0.001)R 145.46 0.001989 4820962000.0 30192.899999999998 35552.4 28891.300000000003 31961.800000000003 32210.7 27945.100000000002 34253.3 32105.6 17152.399999999998 27822.0 True False 30896.335824843623 31389.908480137656 24968.020148551106 26380.27162729241 29297.24787226099 27663.99766612068 31669.54600350998 31254.055194313674 29106.370038269946 31393.2247092294 0.9841720979928611 0.9998943648152601 0.7953314888741161 0.8403173573798803 0.9332347391393594 0.8812091756215044 1.008801940445428 0.9955668932960936 0.9271545152770773 1.0 14.93816560958655 -7.259569345361024 24.98849838416296 0.9825114126771554 0.9032388909943856 0.27761322694270685 0.06092005182421257 244.80297008199244 3271227.289447774 0.026161689735082153 0.01919933108652638 5.50086079276342e-08 7.259569345361024 -0.07927252168276977 TAS(ph)FSESR ddPTM_A459_Selumetinib_30min_R2 6 TASFSESR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 T(0.031)AS(0.968)FS(0.001)ESR;T(0.003)AS(0.993)FS(0.003)ES(0.001)R;T(0.224)AS(0.77)FS(0.005)ESR;TAS(0.973)FS(0.024)ES(0.002)R;TAS(0.993)FS(0.006)ESR;T(0.008)AS(0.991)FS(0.001)ESR 157.34 0.00054282 4891174500.0 2127870.4 1755472.0 2412776.6 2793655.0 2232275.0 1685268.0 1853254.7 1915061.0 1690251.2 1923750.0 True False 2009611.8817081165 1890111.0576678605 2257541.1803885377 2413154.3696763245 1951836.6577082975 1917398.369660274 1939434.7157045212 1920633.510454585 2028348.6695644744 1868206.3389972353 1.0756905379021362 1.0117249996498687 1.2084003427588619 1.2916958471362385 1.044765033157928 1.0263311549887164 1.0381266111887395 1.028062837794186 1.0857198304193723 1.0 20.833222375446795 -6.477671843459035 24.987706640903575 1.0373335792529983 1.1449451168813114 0.35723328073257576 0.0721448495713386 554.9025396791405 306717.47224058583 0.024484543599192648 0.02776178825370647 3.32911008622216e-07 6.477671843459035 0.1076115376283131 TAS(ph)FSESRADEVAPAK ddPTM_A459_Selumetinib_30min_R1 3 TASFSESRADEVAPAK 16 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 T(0.19)AS(0.475)FS(0.285)ES(0.05)RADEVAPAK;T(0.034)AS(0.952)FS(0.009)ES(0.005)RADEVAPAK;T(0.402)AS(0.574)FS(0.019)ES(0.005)RADEVAPAK 165.58 8.4866e-05 104808000.0 6498.9 6676.4 13521.5 14709.8 11513.0 10474.4 9003.3 8293.099999999999 5135.7 6416.200000000001 True False 6650.311725341922 5894.723984225845 11685.354568282979 12141.009567144085 10471.651182785243 10369.037045994275 8324.173832401582 8073.140048214725 8714.907803312832 7239.781769080503 0.9185790314486997 0.8142129379370107 1.6140479010276978 1.6769855714430004 1.4464042586901356 1.4322306081487324 1.1497824240990628 1.1151082043236868 1.2037528314088504 1.0 12.821730495035423 -7.379738445406232 6.259184021455273 1.1225430134803913 1.3295258014635383 0.12271277396712477 0.2611849987512464 0.6206826510495208 29.551113045840843 0.12588172601328806 0.08407961069190624 4.1712051938472585e-08 7.379738445406232 0.20698278798314695 TAS(ph)FSESRADEVAPAK ddPTM_A459_Selumetinib_30min_R2 4 TASFSESRADEVAPAK 16 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 T(0.016)AS(0.982)FS(0.003)ESRADEVAPAK;T(0.021)AS(0.91)FS(0.064)ES(0.005)RADEVAPAK;T(0.035)AS(0.869)FS(0.081)ES(0.014)RADEVAPAK;T(0.197)AS(0.781)FS(0.023)ESRADEVAPAK 136.26 0.0019477 112515700.0 178426.0 247965.0 237724.0 242263.0 211913.0 102692.0 86562.2 90255.7 55261.700000000004 209547.0 True False 168509.79721587015 266983.1181668582 222429.09665432066 209266.3614730152 185290.594413743 116836.89085483902 90587.51381974525 90518.32914436441 66315.58414090812 203496.83364150868 0.8280708559462225 1.3119767683323786 1.0930346810514218 1.028351929257388 0.9105330589082344 0.5741459892229349 0.4451544144383555 0.44481443531365467 0.32588017687652737 1.0 17.634646821138496 -6.654621024353623 2.154524297218996 0.5028518380934169 1.0868123118611472 0.5858476489140751 0.20155105820642605 0.19315092966400976 1.834412235548656 0.07280163100891246 0.07192935280877488 2.2150267512920038e-07 6.654621024353623 0.5839604737677303 TAS(ph)GSSVTSLDGTR ddPTM_A459_Selumetinib_30min_R1 3 TASGSSVTSLDGTR 14 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 T(0.013)AS(0.902)GS(0.078)S(0.005)VT(0.002)SLDGTR;T(0.009)AS(0.623)GS(0.064)S(0.182)VT(0.031)S(0.091)LDGTR;T(0.317)AS(0.653)GS(0.023)S(0.007)VTSLDGTR 259.27 9.930399999999999e-36 350849000.0 10626.099999999999 10977.1 12708.6 13149.3 12671.400000000001 11029.0 11347.699999999999 11034.0 6511.700000000001 9116.3 True False 10873.667455208702 9691.896028884663 10982.841923342898 10853.021597931145 11525.274107317377 10918.058273530774 10491.733852914313 10741.34247651678 11049.879304249118 10286.46590528172 1.0570848681494658 0.9421988191209804 1.0676982769858416 1.055077778691564 1.1204308859274568 1.061400326804637 1.0199551478148772 1.0442208796902246 1.0742153239020034 1.0 13.328459783872306 -5.3015160587899866 24.992269611259534 1.0582171822432536 0.9996417545131299 0.23594041065962357 0.03985585345120169 589.5400760539789 367643.0942205747 0.010171022705295872 0.021173110646669643 4.994407121822244e-06 5.3015160587899866 -0.0585754277301237 TAS(ph)GSSVTSLDGTR ddPTM_A459_Selumetinib_30min_R2 1 TASGSSVTSLDGTR 14 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 T(0.003)AS(0.985)GS(0.01)S(0.001)VT(0.001)SLDGTR 81.703 0.031365 31034000.0 36229.0 35444.0 40486.0 43989.0 41539.0 31709.0 34474.0 36600.0 29280.0 42051.0 True False 34215.53721617788 38162.440829577165 37881.17483782387 37997.62231474243 36320.499456628335 36076.62692435717 36077.10930893508 36706.49994054384 35136.818151555046 40836.87836838081 0.8378587831206583 0.9345092562002877 0.9276217074210678 0.9304732348044322 0.8894044037594848 0.8834325336750175 0.883444346149359 0.8988566562170179 0.8604188066137982 1.0 15.317584968228886 -11.268178881263918 6.6934239328538 1.0020395447020385 0.8966412153561776 0.5356476489266786 0.02951563726134743 0.000930913903163157 3.5423363705579464e-05 0.029614999638691922 0.007050593696627564 5.39288449603835e-12 11.268178881263918 -0.10539832934586091 TAS(ph)LNQRPR ddPTM_A459_Selumetinib_30min_R1 1 TASLNQRPR 9 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 T(0.189)AS(0.811)LNQRPR 100.69 0.0097304 26734000.0 3354.7 2430.1 3107.5 3387.8 2741.7 2283.8 2656.7 2793.5 1394.5 2355.6 True False 3432.8579828901097 2145.582762277161 2685.5185682756614 2796.184326882126 2493.71371908645 2260.8270455244883 2456.30298007856 2719.4073054331748 2366.364649749741 2657.964205487055 1.2915365736691928 0.8072278617777685 1.0103667170279131 1.0520022508616675 0.9382044024289231 0.8505859638204594 0.9241294427546506 1.023116601728224 0.8902921434625264 1.0 11.376105960790834 -4.7465692729257505 24.984074825911982 0.9464431805022769 1.2915374911304687 0.6588362376552934 0.07500957094414278 508.0432463072988 853543.3197331021 0.018806608803609133 0.4232873633726039 1.7923826323339006e-05 4.7465692729257505 0.34509431062819174 TAS(ph)LPGYGR ddPTM_A459_Selumetinib_30min_R1 1 TASLPGYGR 9 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 T(0.137)AS(0.863)LPGYGR 120.27 0.0066319000000000005 67750000.0 2684.3 3215.0 3396.5 3483.3 2810.7 2927.1 3199.9 2928.4 1594.5 2770.4 True False 2746.838967261434 2838.586305387048 2935.273955639028 2875.0070446391496 2556.472681269389 2897.6560315941547 2958.528966745731 2850.7293192162174 2705.7500423276906 3126.007825981209 0.8787050833435583 0.9080547661444375 0.938984839143097 0.9197056452463379 0.8178075115557168 0.9269509844188001 0.9464240435217373 0.9119392777980057 0.8655608664314186 1.0 11.610105674800735 TAS(ph)LSNQECQLYPR ddPTM_A459_Selumetinib_30min_R1 1 TASLSNQECQLYPR 14 0 Q9Y675 Q9Y675 SNURF SNRPN upstream reading frame protein 1 T(0.005)AS(0.914)LS(0.081)NQECQLYPR 217.01 1.2446e-08 8635300.0 489.05 752.5 758.76 850.35 787.88 636.44 561.02 575.16 589.44 657.55 True False 500.4439134743522 664.3969501722413 655.724559570343 701.8523355464363 716.6163931115121 630.0379914412847 518.7018097202066 559.9048884170195 1000.2366290057281 741.9529475793906 0.674495485336425 0.8954704639153002 0.8837818647525205 0.945952621168523 0.9658515347226012 0.84916165303578 0.6991033749679987 0.7546366521538866 1.3481132897564243 1.0 9.535183888148735 -8.25210600795481 24.985741434501886 1.1740566546765647 0.8414894108990469 0.5564999029691814 0.12142306429151856 438.56716737046526 1174066.575549469 0.0855603304470757 0.031354209484445485 5.596209856284182e-09 8.25210600795481 -0.3325672437775178 TAS(ph)LTSAASVDGNR ddPTM_A459_Selumetinib_30min_R1 2 TASLTSAASVDGNR 14 0 G3V578;H0YJT9;A0A0A0MS87;Q9UN36-4;Q9UN36-5;Q9UN36-2;Q9UN36-3;Q9UN36-6;Q9UN36 G3V578 NDRG2 Protein NDRG2 1 T(0.068)AS(0.522)LT(0.324)S(0.002)AAS(0.084)VDGNR;T(0.085)AS(0.456)LT(0.456)S(0.003)AAS(0.001)VDGNR 145.61 0.00051361 27086000.0 2796.0 2777.3 2811.8 3459.2 3183.3 2685.2 2937.8999999999996 2561.3 1575.85 2440.7 True False 2861.1413599310667 2452.13242486826 2429.973004111826 2855.1156572261216 2895.371077057262 2658.18932596653 2716.2918376831385 2493.366003725072 2674.102354469797 2753.9876194312483 1.0389085774183502 0.8903934090214511 0.8823471053270975 1.0367205854817017 1.0513377244793904 0.9652146971218039 0.9863122907735168 0.9053657271850774 0.9709928743332734 1.0 11.427306358504866 -5.760874156872877 24.99999992040366 0.9856692517000041 0.932534079569492 0.15118047155890735 0.05460487682495323 29.415422194740948 1300932.6529956907 0.01594037574421862 0.025621777187095438 1.7343064654126348e-06 5.760874156872877 -0.05313517213051211 TAS(ph)LVTR ddPTM_A459_Selumetinib_30min_R1 1 TASLVTR 7 0 Q7L7X3;Q7L7X3-3;Q7L7X3-2 Q7L7X3 TAOK1 Serine/threonine-protein kinase TAO1 1 T(0.008)AS(0.99)LVT(0.002)R 96.034 0.023406 42752000.0 4061.2 4122.7 5576.7 4965.6 4467.1 4535.8 4511.7 4663.2 2622.5 4229.1 True False 4155.818058280418 3640.0123674087686 4819.414770620394 4098.451175856275 4063.0515937305595 4490.17397017689 4171.378836609491 4539.516787791652 4450.190960178341 4771.946179922438 0.8708853582141544 0.7627940949384161 1.0099474279273466 0.8588636630270817 0.8514453936688362 0.9409523496029606 0.8741462454375988 0.9512925369718725 0.9325735857839605 1.0 12.220362056446934 -1.5228790406954684 0.041434446363566795 1.271386677885468 0.28872774184888994 0.3194392708094843 0.059241701013839826 852.5528675452919 2.696950717563614 17.169876775370103 57.97693298154264 0.029999979593452644 1.5228790406954684 -0.9826589360365782 TAS(ph)NPKVENEDEPVR ddPTM_A459_Selumetinib_30min_R1 2 TASNPKVENEDEPVR 15 1 Q9UBF8-2 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 T(0.006)AS(0.994)NPKVENEDEPVR;T(0.141)AS(0.859)NPKVENEDEPVR 156.29 0.00078156 87990000.0 4789.799999999999 5496.200000000001 6614.2 7684.700000000001 5199.299999999999 5274.4 5466.1 5154.0 3258.6 4555.4 True False 4901.393020671612 4852.702348885941 5716.027969199962 6342.711404684775 4729.024233010972 5221.344324772032 5053.787676217645 5017.2991774485645 5529.6062012725015 5140.129963353591 0.9535542983574254 0.9440816445271119 1.112039580701698 1.2339593453677151 0.9200203626613364 1.0158000599201686 0.9832023143866943 0.9761035641548472 1.075771671279845 1.0 12.327589121730142 TAS(ph)NPKVENEDEPVR ddPTM_A459_Selumetinib_30min_R2 2 TASNPKVENEDEPVR 15 1 Q9UBF8-2 Q9UBF8-2 PI4KB Phosphatidylinositol 4-kinase beta 1 T(0.215)AS(0.785)NPKVENEDEPVR;T(0.012)AS(0.988)NPKVENEDEPVR 134.82 0.0019836 84984000.0 134893.0 126904.0 135795.0 113839.0 122548.0 88273.0 106662.0 105568.0 71141.0 105076.0 True False 127396.18707946362 136637.1287393261 127058.09754241712 98333.9318167714 107152.42464697955 100431.80448748887 111621.99434674342 105875.18540227682 85371.18784562082 102042.18285976526 1.2484659138911396 1.339025929375737 1.2451526807989866 0.9636596264498766 1.050079698846086 0.9842185032979007 1.0938808953170231 1.0375629218729983 0.8366264367643419 1.0 16.638806140576023 -5.69407006782471 5.088870351021143 1.0026218774620685 1.2916837490338813 0.7843062435521817 0.06793670373101354 0.08864302717772286 4.334129663074339 0.018613337444488325 0.03246107207342365 2.0226928169005704e-06 5.69407006782471 0.28906187157181273 TAS(ph)PLPLRPDAPVEK ddPTM_A459_Selumetinib_30min_R1 3 TASPLPLRPDAPVEK 15 1 Q9HCK8-2;Q9HCK8;H0YJG4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 T(0.042)AS(0.958)PLPLRPDAPVEK;T(0.006)AS(0.994)PLPLRPDAPVEK;T(0.013)AS(0.987)PLPLRPDAPVEK 128.64 0.0045214 56574000.0 4488.6 5248.6 5133.2 5424.4 4965.6 4283.1 5308.2 4200.4 1988.2199999999998 3538.83 True False 4593.175646704792 4634.091471992061 4436.139634649277 4477.130368598919 4516.462356747883 4240.0159027436475 4907.798200343663 4088.9917471779117 3373.8641261566354 3993.0733016232616 1.1502858324282643 1.1605325327006177 1.1109587276662063 1.1212241875897642 1.131074241715486 1.0618427417848801 1.2290779130822738 1.0240212083048055 0.8449291739235276 1.0 11.96328384070961 -7.993647600979337 6.928709757906619 0.9254276502957142 1.133708235141862 0.7305227279225753 0.052919549960263705 0.06008230934807548 15.961933432920715 0.028942736353006378 0.012877181853229391 1.0147344364448668e-08 7.993647600979337 0.20828058484614775 TAS(ph)PLPLRPDAPVEK ddPTM_A459_Selumetinib_30min_R2 1 TASPLPLRPDAPVEK 15 1 Q9HCK8-2;Q9HCK8;H0YJG4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 T(0.063)AS(0.937)PLPLRPDAPVEK 106.93 0.020717 6316600.0 22824.0 19143.0 25683.0 30475.0 26026.0 19261.0 19691.0 22315.0 13719.0 18738.0 True False 21555.533451711173 20611.206545553432 24030.58374153609 26324.25242769271 22756.381204607926 21914.027916050458 20606.67051697627 22379.932955552893 16463.18334088743 18196.985252829174 1.184566187872237 1.1326714980081058 1.3205804921889432 1.446627123226357 1.2505577648401887 1.204266949254321 1.1324222243776592 1.229870368338809 0.9047203760484347 1.0 14.151411834310862 -8.25409447825118 23.98455589527636 0.9523601739000522 1.2397271468582867 0.6154475772905637 0.0902074531242101 208.02171998244677 679298.334934976 0.07111995251953643 0.0256086149434976 5.570645495803942e-09 8.25409447825118 0.28736697295823443 TAS(ph)PPALPK ddPTM_A459_Selumetinib_30min_R1 1 TASPPALPK 9 0 Q13029-5;Q13029-3;Q13029-2;Q13029 Q13029-5 PRDM2 PR domain zinc finger protein 2 1 T(0.228)AS(0.772)PPALPK 82.831 0.040344 2974700.0 3934.0 5644.7 4690.1 4878.9 4207.6 4269.0 4213.8 3622.4 2413.9 3614.3 True False 4025.6545457685343 4983.815899850163 4053.210180875198 4026.891703295711 3827.0233229121136 4226.057735941871 3895.9496734501568 3526.322184786515 4096.211995719544 4078.2306112633105 0.9871081185675055 1.2220534773305354 0.9938648809316936 0.987411475009331 0.9384028731339005 1.0362478581447283 0.955303916039047 0.8646696376235989 1.0044091141895144 1.0 11.99372764224297 -5.478512867700338 13.827793412707381 0.9667362454704085 1.1054581952359919 0.3776535336168886 0.0683647070177794 2.725063317988735 847.694412185229 0.017053831886022688 0.035412634088839066 3.322669403363682e-06 5.478512867700338 0.13872194976558339 TAS(ph)PPALPK ddPTM_A459_Selumetinib_30min_R2 1 TASPPALPK 9 0 Q13029-5;Q13029-3;Q13029-2;Q13029 Q13029-5 PRDM2 PR domain zinc finger protein 2 1 TAS(1)PPALPK 128.35 0.004345399999999999 6752300.0 103120.0 120670.0 116170.0 106180.0 107920.0 81988.0 98772.0 99114.0 78525.0 106940.0 True False 97389.00322206684 129925.00098479536 108695.74867633263 91718.10082928334 94362.12478295877 93281.10278703821 103365.09371300493 99402.40533079393 94232.19417181908 103852.36433651131 0.9377639483151164 1.251054820127169 1.0466372082211568 0.8831585242690336 0.9086179730795395 0.898208754157785 0.9953080449673011 0.9571511054741302 0.9073668642389293 1.0 16.66417453585511 -5.584208818025845 5.7642126614894975 0.934670266668718 1.1073993550915868 0.4087469949971806 0.07963858296712387 0.1568244662433869 10.217133479946245 0.02057498368783502 0.03642708721191832 2.604900757139022e-06 5.584208818025845 0.17272908842286883 TAS(ph)PPPPPK ddPTM_A459_Selumetinib_30min_R1 4 TASPPPPPK 9 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.454)AS(0.546)PPPPPK;T(0.144)AS(0.856)PPPPPK;T(0.014)AS(0.986)PPPPPK;T(0.141)AS(0.859)PPPPPK 116.52 0.007824 960585100.0 26672.4 28548.0 30599.9 32811.4 27414.9 25345.1 26145.700000000004 24967.600000000002 15112.1 21785.6 True False 27293.815024544125 25205.586888394875 26444.601653219124 27081.50493625959 24935.227135493707 25090.151305509575 24173.50879897618 24305.37814180538 25644.12995588604 24581.993969714185 1.1103173753183322 1.0253678737147596 1.0757712204225471 1.1016805621881156 1.014369589636004 1.0206719331402268 0.983382748720821 0.9887472176484298 1.0432078857183205 1.0 14.585314324289469 -6.360293071258736 5.95020576861327 1.006466961572215 1.0741391886139526 0.6277561998769372 0.026300780688511317 0.16139784722226702 8.038933854970088 0.008227990190462074 0.009346560742827997 4.362213613352631e-07 6.360293071258736 0.06767222704173759 TAS(ph)PPPPPK ddPTM_A459_Selumetinib_30min_R2 3 TASPPPPPK 9 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 TAS(1)PPPPPK;TAS(1)PPPPPK;T(0.012)AS(0.988)PPPPPK 139.38 0.0023847 466040000.0 579252.0 601420.0 630172.0 637655.0 632698.0 474229.0 508036.0 508999.0 406231.0 576378.0 True False 547059.4927694799 647546.9801299025 589627.419599397 550805.2889837698 553212.8208481142 539549.7401277551 531660.6806542355 510480.1028206795 487488.5510424984 559736.4695301095 0.9773518835189141 1.1568783085967376 1.0534018269246963 0.9840439545526892 0.988345142692825 0.9639352972313902 0.949841058419075 0.9120007907457235 0.8709251184789474 1.0 19.09438822377151 -6.229337160917033 0.9765081329323358 0.927680412305516 1.0752949207741584 0.4890208209196042 0.05278794867448892 0.43695848186080016 0.8785058926210387 0.024138740321590038 0.03942231687400073 5.897430602740144e-07 6.229337160917033 0.14761450846864244 TAS(ph)PPPPPKR ddPTM_A459_Selumetinib_30min_R1 3 TASPPPPPKR 10 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.476)AS(0.524)PPPPPKR;T(0.01)AS(0.99)PPPPPKR;T(0.315)AS(0.685)PPPPPKR 109.72 0.0053116000000000005 592710000.0 14666.2 16716.3 18393.1 20752.9 16934.7 15060.0 16118.2 15011.699999999999 9506.9 13271.300000000001 True False 15007.893924542574 14759.147824802963 15895.418046066316 17128.795595180385 15402.959375064129 14908.510073385933 14902.391197162735 14613.540951126246 16132.514943496468 14974.800628409046 1.0022099323359768 0.985598953271073 1.0614777745962605 1.143841311829217 1.0285919497213747 0.9955731928145105 0.9951645812827089 0.9758754933539853 1.0773108333002508 1.0 13.870249174929434 -6.523039898807761 24.998728120029085 1.0070542979651018 1.0499308651387955 0.13757086867795432 0.0464751850992238 11.930610649079913 1850174.1792726032 0.016437056718184254 0.016609630597442946 2.9988869973837616e-07 6.523039898807761 0.0428765671736937 TAS(ph)PPPPPKR ddPTM_A459_Selumetinib_30min_R2 3 TASPPPPPKR 10 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 T(0.326)AS(0.674)PPPPPKR;T(0.026)AS(0.974)PPPPPKR;T(0.318)AS(0.682)PPPPPKR 114.76 0.008146200000000001 1075909000.0 445645.0 424170.0 445188.0 506424.0 476546.0 388999.0 368646.0 412050.0 329795.0 469501.0 True False 420877.8349582821 456702.47507848195 416545.08876404585 437448.17756987276 416678.0311047066 442580.081268662 385788.76945819135 413248.99728145037 395763.2152422167 455945.28621990356 0.9230884662667435 1.0016607011443324 0.9135856896723022 0.9594312975502293 0.9138772648780971 0.9706868228377835 0.8461295271997273 0.90635655147916 0.8680059366845589 1.0 18.79850118471461 -7.239735992952247 24.991173434141587 0.897319372117009 0.9470702577907655 0.16183796443016008 0.04537998882458014 1170.6617466621178 1348003.5700294296 0.016093085513141935 0.012454829336739472 5.75789852868556e-08 7.239735992952247 0.04975088567375652 TAS(ph)QEGCQELTQEQR ddPTM_A459_Selumetinib_30min_R2 1 TASQEGCQELTQEQR 15 0 A0A0C4DG33;O43933-2;O43933 A0A0C4DG33 PEX1 Peroxisome biogenesis factor 1 1 T(0.008)AS(0.992)QEGCQELTQEQR 166.67 7.8012e-05 14381000.0 10315.0 8091.8 9904.6 12180.0 12450.0 8131.8 7517.6 11182.0 7674.3 7347.1 True False 9741.733594216652 8712.415040762116 9267.3488193131 10521.062988328047 10885.91969558782 9251.881636869266 7867.183295841802 11214.53776872024 9209.374437857892 7134.970132941683 1.3653502975772407 1.2210864065901936 1.2988630150708502 1.474577018865573 1.5257134217462596 1.2966952158851994 1.1026231573863974 1.5717708076931485 1.290737629767898 1.0 12.800691675239495 -6.9770056964508385 24.974199473167076 1.2761773416504618 1.3736852807656048 0.12449479161412536 0.16007137043548222 668.3390597547569 725883.8296919918 0.057751800106931754 0.05092905617186502 1.0543730665500344e-07 6.9770056964508385 0.097507939115143 TAS(ph)QGPQTDSVIQNSENIK ddPTM_A459_Selumetinib_30min_R2 2 TASQGPQTDSVIQNSENIK 19 0 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 T(0.099)AS(0.862)QGPQT(0.036)DSVIQNS(0.003)ENIK;T(0.045)AS(0.955)QGPQTDSVIQNSENIK 334.98 4.614299999999998e-155 23122000.0 107997.0 97021.0 96703.0 87294.0 84872.0 86706.0 94052.0 98748.0 66099.0 99745.0 True False 101994.95908624482 104462.1987283155 90481.23426226564 75404.40660945054 74209.62059469317 98648.96446129859 98425.60436050246 99035.34033138849 79320.64696037007 96865.10268136664 1.052958767015946 1.0784296494470167 0.9340952702016903 0.7784475990026039 0.7661130638430473 1.0184159385635494 1.0161100503270928 1.0224047421614857 0.8188774364003075 1.0 16.56368938310019 -5.296937162158388 5.92008368547322 0.916031707504127 1.0660941194245102 0.27554713987270907 0.09499326558964906 0.24504105071052273 25.953112879540857 0.02741871121253785 0.060378685177152114 5.0473432202573096e-06 5.296937162158388 0.15006241192038317 TAS(ph)TDLK ddPTM_A459_Selumetinib_30min_R2 2 TASTDLK 7 0 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 T(0.137)AS(0.861)T(0.002)DLK;T(0.062)AS(0.935)T(0.003)DLK 108.43 0.016271 69533000.0 310130.0 174383.0 186188.0 273260.0 198344.0 181128.0 485190.0 733520.0 334630.0 407760.0 True False 292894.21614875516 187757.6153702783 174208.86678616717 236041.51660020757 173426.2535021424 206076.73788372267 507752.29638574546 735654.4217592278 401565.3503434037 395986.9093122873 0.7396563099962729 0.47415106649954164 0.4399359238635355 0.5960841407867301 0.43795956235859607 0.5204130061814854 1.2822451562036778 1.8577745992584527 1.014087437993353 1.0 18.595093212361874 -7.28204794456864 5.435301845516604 1.367761846878701 0.5241502127254292 0.7011718633363204 0.23918392033506644 0.08917277377112744 8.650009657933586 0.09491390901846208 0.06581346208413556 5.223385214980646e-08 7.28204794456864 -0.8436116341532718 TASAETPRPSQLAQPSPFQLS(ph)ASVPK ddPTM_A459_Selumetinib_30min_R1 1 TASAETPRPSQLAQPSPFQLSASVPK 26 1 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 TASAETPRPSQLAQPS(0.001)PFQLS(0.787)AS(0.212)VPK 77.584 9.4517e-05 22311000.0 880.32 1093.4 959.06 1274.6 943.88 999.1 987.1 718.91 465.25 717.8 True False 900.8297431954644 965.3842196921308 828.8249197394866 1052.0150372052535 858.5062206555492 989.0499611102186 912.6422522812312 699.8421714512122 789.4952694844509 809.9366219640883 1.112222510708259 1.1919256316019933 1.0233207108595663 1.2988856271915787 1.0599671596200702 1.2211448825610358 1.1268069964142167 0.8640702895420407 0.9747617876197926 1.0 9.661665210419583 -7.684894178099496 6.822453615639189 0.9403832527345427 1.1512457985075657 0.5660307861047502 0.08088838306077739 0.13781174556602357 9.951401036375618 0.035802121273211945 0.020376252063959495 2.0658834757754745e-08 7.684894178099496 0.210862545773023 TASAETPRPSQLAQPSPFQLS(ph)ASVPK ddPTM_A459_Selumetinib_30min_R2 1 TASAETPRPSQLAQPSPFQLSASVPK 26 1 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 TASAETPRPSQLAQPSPFQLS(0.5)AS(0.5)VPK 98.887 1.4265e-06 9702000.0 22152.0 18582.0 18485.0 21438.0 19164.0 17280.0 18493.0 23504.0 15625.0 19708.0 True False 20920.880521482028 20007.179649452737 17295.695224946256 18518.107417387266 16756.44699166627 19660.163147777996 19352.96114318431 23572.392748703343 18750.436598977038 19138.978832466506 1.093103279156816 1.0453629644813367 0.9036895529455633 0.9675598462951418 0.8755141608308478 1.0272315633908 1.0111804455499378 1.2316431798710281 0.9796989046860555 1.0 14.224226235881316 -7.539620346510273 24.999802744456193 1.087685002025419 0.9819967528337614 0.15063991028800772 0.08726896530177534 369.4211105878039 551640.3323027145 0.040834066101821484 0.02358258441702505 2.8865537809733742e-08 7.539620346510273 -0.10568824919165754 TASAETPRPSQLAQPSPFQLSAS(ph)VPK ddPTM_A459_Selumetinib_30min_R1 1 TASAETPRPSQLAQPSPFQLSASVPK 26 1 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 TASAETPRPSQLAQPSPFQLS(0.01)AS(0.99)VPK 94.73 2.4663e-06 29640000.0 4871.1 5277.5 6662.7 6739.5 5200.9 5888.0 4963.5 4972.0 3860.2 4879.8 True False 4984.587152489354 4659.607846556812 5757.941935591386 5562.572841083326 4730.479513293476 5828.772065876254 4589.099198863223 4840.126408667882 6550.477462146969 5506.169863277182 0.9052730439236049 0.8462521066837355 1.0457254459208334 1.0102435956766096 0.859123425312922 1.0585892209302572 0.8334467175576502 0.8790368856850191 1.1896613480515168 1.0 12.426833401883531 -8.252337067998795 24.998844307592993 1.0948306796547072 0.9322150597279164 0.3555719385828988 0.08886518342856686 635.1382182610375 1744373.7638942269 0.06098482107624128 0.02233796067269749 5.593233266358642e-09 8.252337067998795 -0.16261561992679074 TASAETPRPSQLAQPSPFQLSAS(ph)VPK ddPTM_A459_Selumetinib_30min_R2 1 TASAETPRPSQLAQPSPFQLSASVPK 26 1 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 TASAETPRPSQLAQPSPFQLS(0.05)AS(0.95)VPK 88.045 3.5617e-05 9139600.0 22069.0 16886.0 15993.0 20659.0 17501.0 16837.0 15949.0 19259.0 11872.0 21358.0 True False 20842.493329206718 18181.10190295228 14964.027791861801 17845.208561237214 15302.367919074904 19156.1439189316 16690.660102343958 19315.040501500906 14246.73173139554 20741.33904525166 1.0048769408635752 0.8765635556743141 0.7214590995892106 0.8603691652840774 0.7377714565915692 0.923573153938537 0.8047050417492196 0.9312340181779498 0.6868761799955755 1.0 14.34022141601418 -10.912373060849715 3.3284035724606427 1.0015003410652423 0.8381753332272716 0.20059196433569093 0.09665591900687981 140429892.28733873 169092605.85313094 1974832.89678845 0.023063245273625722 1.2235647003069138e-11 10.912373060849715 -0.16332500783797077 TASDTDSSYCIPTAGMS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 TASDTDSSYCIPTAGMSPSR 20 0 Q13480-2;B7Z3B9;Q13480 Q13480-2 GAB1 GRB2-associated-binding protein 1 1 TASDTDSSYCIPT(0.123)AGMS(0.872)PS(0.004)R;TASDTDSSYCIPTAGMS(0.992)PS(0.008)R 247.66 7.964599999999997e-38 13569100.0 3073.8 3634.6 3178.3 3925.8 3151.7 3146.8 3394.6 2855.8999999999996 1699.6599999999999 2999.1000000000004 True False 3145.4135594263635 3209.0593423203004 2746.7043171522214 3240.232726392897 2866.62929147783 3115.1460490657964 3138.542588991859 2780.1522547294085 2884.198881745175 3384.0636987078537 0.9294782366618528 0.9482857381040506 0.8116585743350525 0.9574975576346638 0.8470967294653475 0.9205341052697268 0.9274478462654994 0.8215425305944926 0.8522885910352269 1.0 11.72454100942758 TASDTDSSYCIPTAGMS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 2 TASDTDSSYCIPTAGMSPSR 20 0 Q13480-2;B7Z3B9;Q13480 Q13480-2 GAB1 GRB2-associated-binding protein 1 1 TASDTDSS(0.001)Y(0.003)CIPT(0.007)AGMS(0.948)PS(0.041)R;TASDTDSSYCIPTAGMS(0.997)PS(0.003)R 214.52 1.9626e-17 12670300.0 30331.0 27870.0 33706.0 38803.0 35479.0 26777.0 26659.0 28112.0 26325.0 31376.0 True False 28645.324444613198 30007.539383825635 31537.392656318 33517.964461091404 31021.81083371571 30465.288692595557 27898.696323806354 28193.80126580786 31590.73558195653 30470.093355361765 0.9401127889741937 0.9848194107533073 1.0350277660297493 1.1000282824927188 1.0181068522475287 0.9998423154563337 0.9156091515189623 0.9252942200404072 1.0367784310184127 1.0 14.895106299761283 -7.020825992813758 14.37290245152957 0.9624115789490533 1.0186076034060427 0.15467670410857415 0.04971293747172393 5.876019190281165 4053.2826235998755 0.019884771789823622 0.015803883023787903 9.531779938760326e-08 7.020825992813758 0.05619602445698946 TASES(ph)ISNLSEAGSIK ddPTM_A459_Selumetinib_30min_R1 1 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 T(0.001)AS(0.071)ES(0.841)IS(0.085)NLS(0.002)EAGSIK 202.18 5.0642e-07 63845000.0 2113.9 2997.1 2794.2 2948.3 2737.5 2314.3 2680.7 2220.9 1543.1 2446.5 True False 2163.1497570666256 2646.1981386860116 2414.7629874419463 2433.4347514453543 2489.893608344881 2291.0202432162746 2478.492640756049 2161.9945175001003 2618.527996435157 2760.532105928036 0.7835988403907433 0.9585826344868438 0.8747454819512599 0.8815093098246296 0.9019614743831529 0.8299197963669687 0.8978314852537566 0.7831803560108499 0.9485591530748961 1.0 11.43073066492391 -8.51469774624669 23.09668272332493 1.000000008485711 0.8690711717015428 0.4389938830671749 0.051306643362426727 151.9355630459764 428944.3261247079 0.046330780983934554 0.011962556209600897 3.05704797137092e-09 8.51469774624669 -0.13092883678416822 TASES(ph)NVYLNSFHYPDHSYK ddPTM_A459_Selumetinib_30min_R2 1 TASESNVYLNSFHYPDHSYK 20 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;E9PGF6;A0A1W2PRT1;A0A1W2PRJ2 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 T(0.312)AS(0.312)ES(0.364)NVY(0.012)LNSFHYPDHSYK 49.851000000000006 0.039968 8937100.0 19582.0 16046.0 21660.0 26760.0 27618.0 24500.0 18466.0 23504.0 20158.0 21675.0 True False 18493.710832956906 17276.676603977972 20266.419181624886 23115.241836425164 24148.379931947344 27874.652611143534 19324.705589684836 23572.392748703343 24190.163261579477 21049.18643158675 0.8785950418114471 0.8207764542411156 0.9628124700920873 1.098153694041973 1.1472357855935893 1.324262707337438 0.91807375323 1.1198719164428241 1.1492208185908472 1.0 14.361476852565692 -5.599145815964115 2.6343046557221337 1.117505147668547 0.8508457463720756 0.5225402928803425 0.10025081579949524 0.21138954041937652 2.9460071243646198 0.028956426760563654 0.06020905048013246 2.5168317503959785e-06 5.599145815964115 -0.26665940129647137 TASESIS(ph)NLSEAGSIK ddPTM_A459_Selumetinib_30min_R2 1 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 T(0.002)AS(0.11)ES(0.173)IS(0.714)NLS(0.001)EAGSIK 115.26 0.0020143 8391900.0 17612.0 16517.0 15556.0 16496.0 17296.0 17922.0 12093.0 13568.0 11417.0 17271.0 True False 16633.19554642207 17783.800789474273 14555.143896092177 14249.216342812779 15123.121851798149 20390.592820282243 12655.3484618249 13607.48063369668 13700.71901763334 16772.341354552933 0.9917038530763571 1.0603052020907489 0.8678063240193423 0.8495663212187582 0.9016702875351928 1.2157272732078708 0.7545367813772491 0.8113047752872536 0.8168638312333307 1.0 14.033796477206826 TASESISNLSEAGS(ph)IK ddPTM_A459_Selumetinib_30min_R1 4 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 TASESISNLS(0.001)EAGS(0.999)IK;TASESISNLSEAGS(1)IK;TASESISNLSEAGS(1)IK;TASESISNLSEAGS(1)IK 267.46 2.5533e-50 422967000.0 20221.699999999997 18835.9 24119.7 23713.6 18229.800000000003 18399.199999999997 18976.6 18511.5 12090.2 19451.6 True False 20692.826265421336 16630.584071427653 20844.377220028466 19572.46491940256 16580.917808732604 18214.12075313696 17545.179783851683 18020.514886173678 20516.186366729533 21948.40233462897 0.9427941929410208 0.7577127399924158 0.9496990670314698 0.8917489583522994 0.7554498753912559 0.8298608926263271 0.7993830036626345 0.8210399377335047 0.9347462313628284 1.0 14.421828306654213 -8.464644454047543 3.490979629859897 0.9989690502366347 0.8411763001556685 0.3898135821237445 0.06437232390475732 0.21125204349161025 5.356158222729223 0.06120786880525234 0.01619100730937469 3.430485167966891e-09 8.464644454047543 -0.15779275008096627 TASESISNLSEAGS(ph)IK ddPTM_A459_Selumetinib_30min_R2 6 TASESISNLSEAGSIK 16 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 TASESISNLS(0.003)EAGS(0.997)IK;TASESISNLSEAGS(1)IK;TASESISNLSEAGS(1)IK;TASESISNLSEAGS(1)IK;TASESISNLSEAGS(1)IK;TASESISNLSEAGS(1)IK 232.73 1.6707999999999999e-15 252654700.0 327483.0 328537.0 305404.0 281520.0 283274.0 216217.0 306204.0 269332.0 185301.0 272039.0 True False 309282.80587831815 353734.7314870451 285754.6391387331 243176.49035091238 247686.58761830858 245998.92912749518 320443.09273171495 270115.711529687 222366.37774253066 264184.52722779394 1.1707074942039966 1.3389683915214166 1.0816479001903858 0.9204796847971066 0.9375514539681578 0.9311632732956455 1.2129517806900625 1.0224509147607228 0.8417085590739178 1.0 18.011186447662695 -5.463155402200096 4.77825137343399 0.987996303404499 1.2511273820386009 0.5443822550796582 0.0991196933483323 0.16369131143623059 7.5886781525381375 0.027539101993641433 0.05793511823691575 3.4422673517585264e-06 5.463155402200096 0.2631310786341019 TASESISNLSEAGS(ph)IKK ddPTM_A459_Selumetinib_30min_R1 1 TASESISNLSEAGSIKK 17 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 TASESISNLSEAGS(0.999)IKK 93.062 0.003872 31035000.0 1441.5 2267.2 1510.6 1656.9 1420.9 1796.3 1574.4 1720.8 1126.1 2022.6 True False 1475.0841453292676 2001.755170007315 1305.468817131846 1367.5535188650438 1292.37984588027 1778.230852909905 1455.6417404432887 1675.1587940538402 1910.9094529101362 2282.220411792374 0.6463372852628154 0.8771086086445123 0.5720169753922136 0.5992206150636504 0.5662817838287939 0.7791670093395345 0.6378182111254013 0.7340039486975891 0.837302761396905 1.0 11.156222415308873 -8.488004314986233 1.375311374483614 0.9994691696948396 0.6681348853217433 0.5717537108606738 0.09081703565011501 0.3281809379501704 1.3624595838082882 0.08855382817930814 0.0267715516831117 3.2508406745665897e-09 8.488004314986233 -0.3313342843730963 TASESISNLSEAGS(ph)IKK ddPTM_A459_Selumetinib_30min_R2 2 TASESISNLSEAGSIKK 17 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 TASESISNLSEAGS(1)IKK;TASESISNLS(0.001)EAGS(0.999)IKK 112.14 0.0010026 17543100.0 57013.0 57721.0 62839.0 55350.0 57733.0 50283.0 60416.0 56700.0 44912.0 58026.0 True False 53844.445701122044 62148.01509773232 58796.00715393012 47811.23451592428 50480.064400431496 57209.02682637273 63225.463712032826 56864.98761280969 53895.65494612847 56350.63861034614 0.9555250309308126 1.1028804043814646 1.043395578184894 0.8484594974429625 0.8958206267987744 1.0152329811550527 1.1220008374567816 1.0091276517027636 0.9564337916169253 1.0 15.78214433980957 -6.9804573316958995 24.977024113282358 1.0292177595821443 0.9722016188720966 0.09779405351569992 0.0766376522464381 615.8889100448116 787150.1220585164 0.029999117834537677 0.02645342936499493 1.0460264547954459e-07 6.9804573316958995 -0.05701614071004779 TASFS(ph)ESR ddPTM_A459_Selumetinib_30min_R1 1 TASFSESR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 TAS(0.392)FS(0.608)ESR 173.24 0.0002379 445430000.0 9600.1 12528.0 8710.0 9526.6 9782.1 8780.3 10362.0 10206.0 5531.4 9884.0 True False 9823.763651457175 11061.215935890812 7527.229840605308 7862.958146429917 8897.31078217003 8691.978153874537 9580.385997505939 9935.303726239834 9386.381802528304 11152.707678312974 0.8808411315720217 0.9917964547210295 0.6749239787968622 0.7050268305444652 0.7977713608930429 0.7793603494850444 0.8590188386391139 0.890842297028869 0.8416235835518774 1.0 13.445106392819653 -8.751492876308452 0.73351538771819 0.9980630247620007 0.8066585078206328 0.28954518421038355 0.08601670042760899 1.4177961551950509 1.566090333153147 0.09489133972257219 0.034742811621186226 1.7721771137512615e-09 8.751492876308452 -0.19140451694136795 TASFS(ph)ESR ddPTM_A459_Selumetinib_30min_R2 1 TASFSESR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 TAS(0.001)FS(0.979)ES(0.021)R 131.62 0.0035228 3705900000.0 96565.0 69223.0 92954.0 108030.0 95083.0 75358.0 88487.0 83911.0 71458.0 91340.0 True False 91198.30388032296 74532.18151297323 86973.44084066278 93316.12763785534 83137.82348719485 85737.88046818599 92601.82083366421 84155.16711778616 85751.59670334082 88702.77687017935 1.0281335838425434 0.8402463163250745 0.9805041500330081 1.0520090907010482 0.9372629180354853 0.966574931398905 1.0439562784961207 0.948732047486531 0.9667295628054833 1.0 16.436691648834852 -5.487884851910899 24.968635095563748 0.9874936332714197 0.9282362603680528 0.12828910257357917 0.0548841627869817 1002.8034400946395 715512.9266794377 0.01365080030255694 0.02839361203649115 3.251735018977364e-06 5.487884851910899 -0.059257372903366856 TASFS(ph)ESRADEVAPAK ddPTM_A459_Selumetinib_30min_R1 1 TASFSESRADEVAPAK 16 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 T(0.003)AS(0.028)FS(0.739)ES(0.23)RADEVAPAK 128.82 0.0043763000000000005 132720000.0 2523.8 2728.6 5504.1 5984.8 4351.8 3707.6 3435.7 2890.0 1633.5 2484.6 True False 2582.599629540067 2409.134243508274 4756.673451857139 4939.66702860976 3958.180458372693 3670.3049102314553 3176.542382902062 2813.3478119569977 2771.9301938803887 2803.5226120534608 0.9211980736079823 0.859323992305411 1.696677398429499 1.7619501292310478 1.411859651623603 1.309176139493704 1.1330539547799046 1.003504590924751 0.9887311705504912 1.0 11.45302499069454 -7.4240451786424835 2.3201002277084575 0.996297583675044 1.3490037533629229 0.23525626932410104 0.26812505244697726 0.5183969852155472 5.462707314024491 0.16148362190548363 0.09329794273965238 3.7666461340413614e-08 7.4240451786424835 0.35270616968787893 TASFS(ph)ESRADEVAPAKK ddPTM_A459_Selumetinib_30min_R1 1 TASFSESRADEVAPAKK 17 2 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 T(0.149)AS(0.125)FS(0.549)ES(0.178)RADEVAPAKK 60.938 0.022735 78039000.0 2837.6 2517.0 10284.0 11011.0 6782.4 5214.3 4062.5 4641.7 2906.8 2881.3 True False 2903.7105589915586 2222.3084698784464 8887.48928596843 9088.135552068925 6168.933117529974 5161.848876205598 3756.0623542624853 4518.587037633493 4932.627295727893 3251.1429212386847 0.8931353155908771 0.6835468399007656 2.733650750297467 2.7953663595343716 1.8974659887236245 1.5877028482767945 1.1553052096619076 1.3898457087552192 1.5171979255370796 1.0 11.66673126340032 -7.005772553833342 4.015562948331106 1.3012419862493882 1.842008870967162 0.13101079933599769 0.6417269827576854 0.5305557033092463 19.66251312795467 0.27786693456793743 0.22737878378781998 9.867961494367212e-08 7.005772553833342 0.5407668847177738 TASFSESR ddPTM_A459_Selumetinib_30min_R2 2 TASFSESR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 ; 138.83 0.033844 6797800.0 43662.0 43247.0 46802.0 50627.0 53362.0 35383.0 39516.0 40771.0 30807.0 45853.0 False True 41235.44083283443 46563.90583897768 43790.81027416468 43731.51526355374 46658.18849766728 40256.68707510582 41353.57229946853 40889.63685999763 36969.2608194999 44529.10474959851 0.9260334575490476 1.0456959802093824 0.9834199569116536 0.9820883556826513 1.0478133068257558 0.9040533669266906 0.928686362144781 0.9182676608913029 0.8302269050184132 1.0 15.442460986472913 -6.779839297015524 24.99954949487365 0.9119160294347846 0.9981309715730083 0.3912340410404952 0.050217437834269574 234.01137794614564 317943.83014254353 0.016805938746270548 0.014848691539897357 1.6602011218246562e-07 6.779839297015524 0.08621494213822378 TASGSSVTS(ph)LDGTR ddPTM_A459_Selumetinib_30min_R1 1 TASGSSVTSLDGTR 14 0 E5RJY1;E7ESM1;Q92597-3;Q92597-2;Q92597 E5RJY1 NDRG1 Protein NDRG1 1 TASGSS(0.001)VT(0.032)S(0.967)LDGTR 141.34 0.00055507 16637000.0 3629.4 4187.3 4623.9 5070.6 4587.1 3876.8 4348.6 4086.2 2172.2 3214.5 True False 3713.957958416958 3697.0489693770437 3995.999777264627 4185.114896950385 4172.197614918285 3837.8029118527634 4020.5816009220557 3977.820702151792 3686.064748789091 3627.112386881532 1.0239434465415318 1.019281614418251 1.1017027737318754 1.1538420789184876 1.1502807660463474 1.058087674849352 1.1084800171794 1.096690777087221 1.0162532493122565 1.0 11.824605732888573 -10.257627057400956 11.018567380046534 1.0000041197205272 1.0845309675436794 0.19792705401749444 0.048407412009277014 0.0 0.0 0.05063921887591249 0.01228181460142111 5.525517294974583e-11 10.257627057400956 0.08452684782315223 TASIS(ph)S(ph)SPSEGTPTVGSYGCTPQSLPK ddPTM_A459_Selumetinib_30min_R1 1 TASISSSPSEGTPTVGSYGCTPQSLPK 27 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 2 T(0.248)AS(0.316)IS(0.413)S(0.351)S(0.281)PS(0.218)EGT(0.153)PT(0.016)VGS(0.003)Y(0.001)GCTPQSLPK 74.321 0.00061092 5475300.0 889.01 757.46 1009.2 1305.1 1055.1 1010.3 1058.3 912.19 454.64 880.09 True False 909.722203287668 668.7762310663992 872.1561831387921 1077.1887847611615 959.6663912930346 1000.1372992790044 978.471578957782 887.9957579892922 771.4908744081914 993.0581243025564 0.9160815273794605 0.6734512459037516 0.8782529056406683 1.0847187676126124 0.9663748453465668 1.0071286612567818 0.9853114888365484 0.8942032054900598 0.7768839059143936 1.0 9.955734351827411 -5.521554557021933 24.99750192764189 0.9599943351369843 0.7900377938041383 0.33386760057419373 0.09348652261879174 49.60206573830466 936365.9265597009 0.02553760909396367 0.04502337123760382 3.009161127731374e-06 5.521554557021933 -0.169956541332846 TASIS(ph)SSPSEGTPTVGSYGCTPQSLPK ddPTM_A459_Selumetinib_30min_R1 1 TASISSSPSEGTPTVGSYGCTPQSLPK 27 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 1 T(0.13)AS(0.022)IS(0.788)S(0.03)S(0.03)PSEGTPTVGSYGCTPQSLPK 199.29 4.1199000000000005e-40 16810000.0 1381.3 1431.8 1606.9 1663.6 1458.4 1243.4 1616.5 1594.3 941.27 1018.1 True False 1413.4816024580773 1264.1641903742393 1388.691806069883 1373.0834896396207 1326.487977501433 1230.892524916871 1494.5661035483836 1552.0139849837515 1597.2664423592241 1148.7830521337958 1.2304164827576625 1.1004377093012732 1.208837302648634 1.195250475787574 1.1546897171207053 1.0714751776939622 1.3009994365535917 1.3510070348800658 1.3903986826689316 1.0 10.165890655176215 -7.286874093923797 24.131799199357904 1.289851909522163 1.1610243506077667 0.1497057368639202 0.10862352664070814 711.886958751052 675415.8569404846 0.043091443488092324 0.02906817844844738 5.165661049636653e-08 7.286874093923797 -0.12882755891439635 TASISS(ph)SPSEGTPT(ph)VGSYGCTPQSLPK ddPTM_A459_Selumetinib_30min_R1 1 TASISSSPSEGTPTVGSYGCTPQSLPK 27 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 2 T(0.017)AS(0.031)IS(0.169)S(0.679)S(0.109)PS(0.051)EGT(0.074)PT(0.589)VGS(0.206)Y(0.05)GCT(0.018)PQS(0.005)LPK 82.94200000000002 0.00026162 10386000.0 2086.7 2027.2 2435.9 2452.6 2125.6 2717.6 2627.9 2125.1 1289.7 1759.1 True False 2135.3160499886126 1789.8544815802888 2105.1181594409277 2024.299451003926 1933.3398553051609 2690.263411383375 2429.675387265573 2068.7354447023563 2188.526704038896 1984.8976200850211 1.0757814551146212 0.9017364238179812 1.0605676273372513 1.0198508127170898 0.9740249752641389 1.3553663343443076 1.2240809614963921 1.04223785840085 1.1025892126089367 1.0 10.954848880541766 TASISSS(ph)PSEGTPTVGSYGCT(ph)PQSLPK ddPTM_A459_Selumetinib_30min_R1 1 TASISSSPSEGTPTVGSYGCTPQSLPK 27 0 Q6PKG0;Q6PKG0-3 Q6PKG0 LARP1 La-related protein 1 2 T(0.007)AS(0.003)IS(0.044)S(0.164)S(0.76)PS(0.023)EGTPT(0.006)VGS(0.341)Y(0.064)GCT(0.578)PQS(0.01)LPK 99.863 4.3695e-06 6352400.0 3548.3 4619.7 5170.0 5342.4 4511.2 4508.7 4249.8 3556.3 2008.6 3801.1 True False 3630.968486210089 4078.8233763597373 4467.942396777207 4409.450129268278 4103.162756517051 4463.346571572058 3929.234164466393 3461.9753715095726 3408.447497660329 4289.008210849396 0.8465753171153317 0.9509945366954581 1.0417192453666053 1.0280815313233056 0.9566693638258296 1.0406477097156537 0.9161171933705033 0.8071738736130706 0.7946936284799789 1.0 12.066428362524194 -7.523952643337523 6.3245061191367355 0.8519956245233093 0.9805596251066734 0.29948104312149093 0.07498202432305566 0.1566979563936712 28.97237219128708 0.03436651686177946 0.020800552550219762 2.9925909391482886e-08 7.523952643337523 0.12856400058336404 TASLT(ph)SAASVDGNR ddPTM_A459_Selumetinib_30min_R1 1 TASLTSAASVDGNR 14 0 G3V578;H0YJT9;A0A0A0MS87;Q9UN36-4;Q9UN36-5;Q9UN36-2;Q9UN36-3;Q9UN36-6;Q9UN36 G3V578 NDRG2 Protein NDRG2 1 T(0.115)AS(0.315)LT(0.567)S(0.002)AASVDGNR 214.58 2.5188e-06 15865000.0 1363.6 1676.4 1461.4 1709.1 1249.4 1326.1 1771.1 1495.6 741.6 1174.7 True False 1395.3692268962816 1480.126308662783 1262.9499068955913 1410.637768780402 1136.3919905994853 1312.7606380024633 1637.50450107921 1455.931829606534 1258.441035679031 1325.4841875469704 1.052724159221126 1.1166684013047365 0.9528215566516043 1.0642433776528277 0.8573410390527316 0.9904008288714073 1.2354010077703645 1.0984150873206406 0.9494198780356529 1.0 10.372303744242105 TASLTSAAS(ph)VDGNR ddPTM_A459_Selumetinib_30min_R1 1 TASLTSAASVDGNR 14 0 G3V578;H0YJT9;A0A0A0MS87;Q9UN36-4;Q9UN36-5;Q9UN36-2;Q9UN36-3;Q9UN36-6;Q9UN36 G3V578 NDRG2 Protein NDRG2 1 T(0.014)AS(0.33)LT(0.257)S(0.017)AAS(0.382)VDGNR 111.72 0.0038427 7234700.0 1306.3 1292.8 1247.6 1017.7 1288.2 1299.2 1127.8 1204.5 512.98 1124.3 True False 1336.7342483826733 1141.4383749935853 1078.1827725762557 839.9777995950001 1171.6825374501825 1286.1312275792181 1042.7291380030115 1172.5527472325955 870.4895934231783 1268.6148566093964 1.0536958805254246 0.8997517008781425 0.8498897572884295 0.6621219948818772 0.9235920037872778 1.013807477406214 0.821943029100175 0.924277956484331 0.6861732612447248 1.0 10.309038427287772 TASPPPPPKR ddPTM_A459_Selumetinib_30min_R1 1 TASPPPPPKR 10 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 0 100.25 0.023855 1333300.0 692.29 592.8 766.07 839.58 779.72 598.32 584.86 882.7 383.55 498.89 False True 708.4190100381537 523.3947004147569 662.0419017212984 692.9631138684979 709.1944636707466 592.3014440310939 540.7435393265126 859.2879285863116 650.8563366163592 562.9273911001176 1.2584553909407479 0.929773019912741 1.1760697954801653 1.2309991036574968 1.2598329285146033 1.052180891168879 0.960591983754332 1.5264631676689646 1.1561994440249281 1.0 9.136805038802756 -5.478519520795795 24.971007157272012 1.1832670579709197 1.0838159748638456 0.026911315249450674 0.16770201254517 1421.9451762836295 800448.4798464804 0.043679215001331054 0.0909182157986809 3.3226185027229597e-06 5.478519520795795 -0.09945108310707407 TASQGPQT(ph)DSVIQNSENIK ddPTM_A459_Selumetinib_30min_R1 1 TASQGPQTDSVIQNSENIK 19 0 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 TAS(0.001)QGPQT(0.515)DS(0.015)VIQNS(0.47)ENIK 161.25 3.4107e-06 5464200.0 1100.5 1492.6 1536.2 1810.0 1384.8 1300.1 1657.8 1367.7 729.38 1382.0 True False 1126.1395087997646 1317.8456981090858 1327.5924777425814 1493.9174779079783 1259.5450845062976 1287.0221743963525 1532.7508112975622 1331.424153084285 1237.7045881925187 1559.3931618199647 0.7221652219414951 0.845101626950211 0.8513519939981979 0.9580120744946901 0.8077148953483193 0.8253352688133322 0.9829149241033556 0.8538091519719008 0.7937091289716803 1.0 10.606768997879128 -12.947700395047589 0.018884531081608615 1.9890881391786812 1.3168757153990285e-06 0.2953975378460262 0.07113533266371727 4092.0560559467613 7.67308096816471 500.77000792929925 324.21033781210474 1.1279753395467017e-13 12.947700395047589 -1.9890868223029659 TASQGPQTDS(ph)VIQNSENIK ddPTM_A459_Selumetinib_30min_R1 1 TASQGPQTDSVIQNSENIK 19 0 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 T(0.035)AS(0.318)QGPQT(0.043)DS(0.589)VIQNS(0.014)ENIK 150.51 2.6237e-05 7523400.0 1228.4 1626.0 1820.0 1648.2 1430.0 1805.6 1535.2 1149.6 973.38 1356.5 True False 1257.019329949687 1435.627164093107 1572.8539965443927 1360.372810545818 1300.6567524870063 1787.4373033536297 1419.3986280033885 1119.1088735729286 1651.7547671376137 1530.6199884289306 0.8212484741166391 0.9379383354105242 1.0275927457074516 0.8887724064953191 0.8497581126077122 1.1677864635678143 0.9273357454715441 0.7311474317812954 1.0791409883736192 1.0 10.579900429772735 -4.770910385668609 5.053925339288089 0.951266017833425 0.814184716287053 0.10847284408092983 0.11605639573095235 0.4007467906426986 27.301137305323426 0.02884736443452827 0.19188421143178253 1.6946874540163055e-05 4.770910385668609 -0.137081301546372 TASRPAPLVQQLS(ph)PSLLPNSK ddPTM_A459_Selumetinib_30min_R2 1 TASRPAPLVQQLSPSLLPNSK 21 1 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 T(0.004)AS(0.004)RPAPLVQQLS(0.8)PS(0.191)LLPNS(0.002)K 51.463 0.029323 9630800.0 37424.0 44700.0 39987.0 57854.0 57525.0 38282.0 34031.0 42965.0 33883.0 51590.0 True False 35344.12390014192 48128.34626684627 37414.27995455372 49974.18539628335 50298.19521997508 43554.998010603966 35613.508931147204 43090.02103676137 40660.54677012091 50100.46265308236 0.7054650202510141 0.9606367629797774 0.7467851188047234 0.9974795191478887 1.0039467213758466 0.8693532096140095 0.7108419173242132 0.8600723177974549 0.8115802652696528 1.0 15.612536305609169 -11.983319640501916 2.135660470739671 2.3739072098653007 0.8572823003870175 0.14964409004541834 0.10525822122294935 9363579.849805048 607617.8943761422 62449291.19967532 0.02652702923968387 1.0391550667447348e-12 11.983319640501916 -1.516624909478283 TASRPAPLVQQLSPS(ph)LLPNSK ddPTM_A459_Selumetinib_30min_R1 1 TASRPAPLVQQLSPSLLPNSK 21 1 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 TASRPAPLVQQLS(0.144)PS(0.822)LLPNS(0.033)K 60.325 0.011183 20507000.0 2611.2 2994.6 4355.1 4189.0 3726.7 3151.4 3312.7 3060.9 2038.3 2532.2 True False 2672.0358794892722 2643.990839848228 3763.701340851917 3457.469787268798 3389.6206430023253 3119.699777242262 3062.8203719299295 2979.714988795561 3458.8462284581556 2857.232535716724 0.9351832047576079 0.9253677489658694 1.31725412398323 1.210076444268652 1.1863299891172678 1.0918606512576685 1.071953484234574 1.0428675130734897 1.2105581835643346 1.0 11.480402739373034 -5.2228703076411795 24.651420921389704 1.1427067641767568 0.9302752610904862 0.47278192020713605 0.0891542972353946 411.4126804084874 262952.9052870767 0.023521435627587257 0.06222890887301337 5.985903240192556e-06 5.2228703076411795 -0.21243150308627057 TASRPAPLVQQLSPS(ph)LLPNSK ddPTM_A459_Selumetinib_30min_R2 1 TASRPAPLVQQLSPSLLPNSK 21 1 Q9Y6X9-2;Q9Y6X9 Q9Y6X9-2 MORC2 MORC family CW-type zinc finger protein 2 1 TASRPAPLVQQLS(0.319)PS(0.503)LLPNS(0.178)K 72.755 0.0024011 8586100.0 45422.0 40174.0 52309.0 62005.0 52700.0 40035.0 46082.0 47624.0 34771.0 52933.0 True False 42897.62707867269 43255.21662023005 48943.49588973294 53559.81203540893 46079.35485602236 45549.45784845437 48224.90430975067 47762.5779554224 41726.17158291397 51404.68675354932 0.8345080923134066 0.8414644529906298 0.9521212749410161 1.0419246846535994 0.896403767168968 0.8860954268009293 0.9381421686500386 0.929148312573358 0.8117192072964615 1.0 15.649612280755688 -5.250366165631103 21.6441695095111 0.9306563868325652 0.8379861371637418 0.287120537458771 0.05919239415922918 158.16011781177144 309133.7849869239 0.015475310188354388 0.039816469939108784 5.618673995592886e-06 5.250366165631103 -0.09267024966882342 TASRPDDIPDS(ph)PSSPK ddPTM_A459_Selumetinib_30min_R1 1 TASRPDDIPDSPSSPK 16 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 TASRPDDIPDS(0.93)PS(0.064)S(0.006)PK 236.27 1.4569e-20 5955800.0 1323.9 1730.8 1614.5 1462.0 1381.5 1321.2 1255.5 1409.4 898.3 1256.8 True False 1354.744294139034 1528.1571313729103 1395.2597678136933 1206.6891451389306 1256.5435689236358 1307.90992755362 1160.7966241911504 1372.0181336235962 1524.3494907638521 1418.1225222686912 0.9553083551424981 1.0775917506254589 0.9838781529127523 0.8509061284835159 0.8860613587276198 0.9222827414525828 0.8185446644864827 0.9674891358672325 1.074906763574434 1.0 10.469766467897703 -11.209035196346735 14.290791954570473 1.0000018119492908 0.9446370907756875 0.03315826348312334 0.08089419547217198 5.04490252714089e-06 1.107716605643238e-07 0.0846123816050855 0.020520845254496156 6.1796631652229555e-12 11.209035196346735 -0.05536472117360336 TASRPDDIPDSPS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 3 TASRPDDIPDSPSSPK 16 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 TASRPDDIPDSPS(0.945)S(0.055)PK;TASRPDDIPDSPS(0.915)S(0.085)PK;TASRPDDIPDS(0.038)PS(0.913)S(0.049)PK 211.9 1.6038e-07 19730700.0 124751.0 98558.0 110984.0 107672.0 93534.0 78517.0 103253.0 99353.0 70635.0 117252.0 True False 117817.83883782082 106117.08168608128 103843.4102702426 93006.8878554401 81783.4227154306 89332.0040436391 108054.46909193808 99642.10078122553 84763.97370679953 113866.63010271778 1.03470032204816 0.9319418831518441 0.9119740364368969 0.8168054834988938 0.7182387205246586 0.7845319033596913 0.9489564150134537 0.8750772784909813 0.7444145280345517 1.0 16.796985485407347 -5.080021456777222 1.5043923579615592 0.8353117250901336 1.0470162373922682 0.33369668003138875 0.08339519207654246 0.770198329256294 2.410582178099726 0.02501588933649548 0.20614951278583493 8.31722677950871e-06 5.080021456777222 0.2117045123021346 TASRPDDIPDSPSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 TASRPDDIPDSPSSPK 16 1 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 1 TASRPDDIPDS(0.005)PS(0.14)S(0.855)PK;TASRPDDIPDS(0.061)PS(0.381)S(0.558)PK;TASRPDDIPDSPS(0.229)S(0.771)PK 190.18 1.1022000000000001e-13 26931800.0 185918.0 164908.0 167837.0 170900.0 160450.0 128866.0 172586.0 167869.0 117577.0 192348.0 True False 175585.4218487221 177555.9133372053 157038.55014710844 147623.1251810563 140292.83655880048 146616.12177092332 180611.59097267123 168357.47099779086 141095.68537586738 186794.41345987775 0.9399928969847737 0.9505418821068928 0.8407026058134192 0.7902973244580722 0.7510547770687719 0.7849063526860536 0.9669003886535689 0.9012982127217256 0.7553528114810234 1.0 17.51109178283422 -10.175489637461517 15.288630396140507 0.9999999591045052 0.8537895088075316 0.24051163781129759 0.07812478233322165 0.0 0.0 0.08214847540035648 0.019923931827007288 6.675908299098065e-11 10.175489637461517 -0.14621045029697366 TAST(ph)PTPPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_A459_Selumetinib_30min_R2 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9J2Z7;C9JF13;C9K073;C9J556;C9JWW9;C9JSU8;C9J6B6;C9JWH7 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 T(0.055)AS(0.106)T(0.411)PT(0.233)PPQT(0.194)GGGLEPQANGET(0.001)PQVAVIVRPDDR 43.302 0.015806999999999998 7564500.0 19052.0 18816.0 22010.0 19461.0 23800.0 19437.0 17709.0 17019.0 12708.0 15497.0 True False 17993.1661111988 20259.126697024145 20593.900562676066 16810.378227902478 20810.031225300416 22114.270318481522 18532.503589717795 17068.522472352877 15249.955091187216 15049.561343958465 1.1955940575252728 1.3461606111966196 1.368405370229833 1.1170012097828272 1.3827666301818458 1.4694295609724952 1.231431479373818 1.1341541512241424 1.0133155872552522 1.0 13.877433816293987 -7.8849646899564645 2.16434466348431 1.010796384010664 1.3124692727197906 0.6239632159273544 0.09423080959567239 0.22113863663408204 1.985387380167593 0.07403980123552865 0.02775424399449532 1.3032727359264438e-08 7.8849646899564645 0.3016728887091267 TASTPT(ph)PPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_A459_Selumetinib_30min_R1 2 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9J2Z7;C9JF13;C9K073;C9J556;C9JWW9;C9JSU8;C9J6B6;C9JWH7 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 T(0.003)AS(0.04)T(0.142)PT(0.763)PPQT(0.044)GGGLEPQANGET(0.008)PQVAVIVRPDDR;T(0.002)AS(0.012)T(0.057)PT(0.695)PPQT(0.229)GGGLEPQANGET(0.005)PQVAVIVRPDDR 107.36 7.139900000000001e-14 252970000.0 1408.66 1668.93 1805.72 2170.13 1663.9899999999998 1433.8400000000001 1957.23 1256.3400000000001 894.4000000000001 1222.95 True False 1441.479037224785 1473.5308997354919 1560.5131421099688 1791.1575338853272 1513.4823983012943 1419.4168714225557 1809.5945653250863 1223.0177820325443 1517.7314756085839 1379.9275450417697 1.0446048724834696 1.0678320793218812 1.1308659992454408 1.2980083920501129 1.0967839606792413 1.0286169563921492 1.3113692612537209 0.8862913030665854 1.0998631638754939 1.0 10.43037680300384 -7.778954018839579 24.999949598328605 0.9948080047198313 1.136782814755937 0.2920680806464865 0.10290742937183725 332.1600654725008 474109.9589489256 0.05550349101969415 0.02675940003670823 1.6635887743971412e-08 7.778954018839579 0.14197481003610557 TASTPT(ph)PPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_A459_Selumetinib_30min_R2 3 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9J2Z7;C9JF13;C9K073;C9J556;C9JWW9;C9JSU8;C9J6B6;C9JWH7 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 T(0.007)AS(0.042)T(0.102)PT(0.419)PPQT(0.419)GGGLEPQANGET(0.011)PQVAVIVRPDDR;T(0.01)AS(0.039)T(0.148)PT(0.64)PPQT(0.157)GGGLEPQANGET(0.006)PQVAVIVRPDDR;T(0.008)AS(0.079)T(0.316)PT(0.471)PPQT(0.023)GGGLEPQANGET(0.102)PQVAVIVRPDDR 75.10300000000002 0.00035898 44639000.0 39414.0 33892.1 40023.0 44033.0 44067.0 31379.8 35247.6 30941.4 33189.1 34093.0 True False 37223.52766674308 36491.515089722176 37447.96375374758 38035.62943883818 38530.909496021595 35702.08261253724 36886.683241794366 31031.4343513755 39827.84738093496 33108.64650574796 1.124284185410018 1.102174777316461 1.1310629610680787 1.148812574752485 1.16377181076648 1.0783310820736522 1.1141102743475335 0.9372607347747715 1.2029439915044697 1.0 15.014920413559569 -7.203782133143851 2.115074928793491 1.0539108310862373 1.1312334113035374 0.19810705550225127 0.06686716529934471 0.5081767386239912 4.448870234052967 0.03022712317971004 0.020365359590139732 6.254863936962864e-08 7.203782133143851 0.0773225802173001 TASTPTPPQT(ph)GGGLEPQANGETPQVAVIVRPDDR ddPTM_A459_Selumetinib_30min_R1 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9J2Z7;C9JF13;C9K073;C9J556;C9JWW9;C9JSU8;C9J6B6;C9JWH7 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 T(0.001)AS(0.005)T(0.014)PT(0.293)PPQT(0.344)GGGLEPQANGET(0.344)PQVAVIVRPDDR 67.138 0.00016073 114950000.0 319.45 492.9 404.68 371.96 480.83 337.75 322.27 361.45 232.29 384.35 True False 326.8925634585047 435.1910388570067 349.7266787481238 307.0041685539512 437.3390113974313 334.35254165246374 297.96091443893465 351.86317184493316 394.1791642096577 433.6850663860374 0.7537556369707387 1.0034725024855449 0.8064070124951467 0.7078965644638467 1.0084253420156768 0.770957009054228 0.6870444420000152 0.8113333824866548 0.908906473295038 1.0 8.760503955729398 -8.51412312472059 3.2304122486739266 0.9991089120728395 0.8215403037673759 0.23871469920187238 0.10327507500783044 0.3347482280302335 8.732542452153067 0.10038861926583371 0.02664791848826378 3.061095474340999e-09 8.51412312472059 -0.17756860830546362 TASTPTPPQTGGGLEPQANGET(ph)PQVAVIVRPDDR ddPTM_A459_Selumetinib_30min_R1 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-9;Q04637;Q04637-8;Q04637-3;E7EUU4;Q04637-7;Q04637-5;Q04637-4;Q04637-6;E9PGM1;E7EX73;C9J2Z7;C9JF13;C9K073;C9J556;C9JWW9;C9JSU8;C9J6B6;C9JWH7 Q04637-9 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 TAS(0.001)T(0.002)PT(0.021)PPQT(0.185)GGGLEPQANGET(0.791)PQVAVIVRPDDR 58.712 0.00092404 139530000.0 1607.9 1960.2 2264.2 2002.8 2561.3 1488.8 1820.2 1686.1 1100.9 1699.6 True False 1645.3609415712308 1730.6988727277435 1956.7340763603374 1653.0485772122104 2329.630867234244 1473.8240237222437 1682.9008485485726 1641.3791507753251 1868.1468934453142 1917.7602155059415 0.8579596803957857 0.9024584297527272 1.0203225932727538 0.861968333604264 1.2147665012539866 0.7685131914854231 0.8775345504310567 0.8558834089392652 0.9741295488041302 1.0 10.905206630916792 -9.712753231065609 15.362006517280987 0.9999912981027488 0.9265310506634619 0.03500862300117247 0.11659905831974518 0.0 0.0 0.11042115957571862 0.026781064954933584 1.9375225640891246e-10 9.712753231065609 -0.07346024743928692 TAT(ph)ESFASDPILYRPVAVALDTK ddPTM_A459_Selumetinib_30min_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 T(0.141)AT(0.679)ES(0.177)FAS(0.001)DPILY(0.002)RPVAVALDTK 89.29700000000003 0.00026734 27231000.0 2961.3 5668.3 5235.4 5939.8 4637.2 4529.0 4978.8 4739.8 1896.3 3717.5 True False 3030.29252831326 5004.652800878823 4524.46143599369 4902.525433855147 4217.766078764156 4483.442372002983 4603.245107545126 4614.085106959786 3217.882599727812 4194.677336516438 0.7224137365544862 1.1930960117745424 1.078619658443414 1.168749117167271 1.0055042951806379 1.0688408219084513 1.0974014776945853 1.099985704929489 0.7671347142043047 1.0 12.03434412443065 -8.244718845179767 24.883087123527474 0.8835673399205355 1.063868133741898 0.2055683053805537 0.1332222742885223 936.9992301133677 1394424.952737709 0.08506702465569928 0.0319587905460734 5.692213157328582e-09 8.244718845179767 0.18030079382136255 TATCHSSS(ph)SPPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R1 5 TATCHSSSSPPIDAASAEPYGFR 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TATCHS(0.001)S(0.051)S(0.896)S(0.051)PPIDAASAEPYGFR;TATCHSSS(0.632)S(0.368)PPIDAASAEPYGFR;TATCHSSS(0.973)S(0.027)PPIDAASAEPYGFR;TATCHSSS(0.631)S(0.368)PPIDAASAEPYGFR;TATCHS(0.001)S(0.006)S(0.496)S(0.496)PPIDAASAEPYGFR 157.96 1.0952e-09 1812306000.0 6886.83 7610.2300000000005 7212.45 8091.96 12748.98 7234.61 9537.96 6364.969999999999 2094.54 4050.66 True False 7047.279739561546 6719.220733700061 6233.038905151987 6678.851090901795 11595.837010015237 7161.836391900306 8818.503998144348 6196.150319263641 3554.2814008510745 4570.6016677696525 1.5418713446977004 1.4700954539709177 1.363723937945694 1.4612629969482593 2.5370482603603777 1.5669351460669108 1.9293967488633883 1.3556530998876606 0.7776397199333017 1.0 12.158168376854041 -8.047420808864048 4.039629139499139 0.9083592816698628 1.6922346920881253 0.49483132599014656 0.32412865856756445 0.2019341406309546 6.766696983651582 0.2442978333792871 0.08970646185197514 8.96559653614368e-09 8.047420808864048 0.7838754104182625 TATCHSSS(ph)SPPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R2 2 TATCHSSSSPPIDAASAEPYGFR 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.054)AT(0.168)CHS(0.197)S(0.153)S(0.231)S(0.197)PPIDAASAEPYGFR;TAT(0.001)CHS(0.003)S(0.003)S(0.604)S(0.388)PPIDAASAEPYGFR 62.717 0.004672399999999999 30600000.0 33654.0 27356.0 32673.0 41526.0 36894.0 33723.0 22572.9 34241.0 29794.0 32694.0 True False 31783.64540763617 29454.11723659615 30570.85475167265 35870.0871636544 32259.045883455186 38368.03714308546 23622.584577352787 34340.63564109729 35753.632513915 31750.039270786507 1.0010584596939565 0.9276875844275615 0.9628603760437288 1.1297651274610796 1.016031684506829 1.208440620052657 0.744017491628369 1.0815934855455254 1.1260972690138444 1.0 14.954470755866817 -5.578036368677595 24.97475659766446 1.0407903644480658 0.9595973749708372 0.08776472498455545 0.11749617854031558 215.5009373998253 97575.08526190401 0.031714092688150584 0.05493042907488498 2.6421874860591373e-06 5.578036368677595 -0.08119298947722864 TATCHSSSS(ph)PPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R1 4 TATCHSSSSPPIDAASAEPYGFR 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TATCHSSS(0.001)S(0.999)PPIDAASAEPYGFR;TATCHSSS(0.052)S(0.948)PPIDAASAEPYGFR;T(0.032)AT(0.032)CHS(0.032)S(0.032)S(0.172)S(0.698)PPIDAASAEPYGFR;TATCHSSS(0.073)S(0.926)PPIDAASAEPYGFR 151.16 4.2879e-08 383797000.0 5030.92 5729.199999999999 5824.75 5972.66 7052.700000000001 5678.15 6432.94 5349.08 2427.06 4339.78 True False 5148.130647533764 5058.422600567178 5033.780943061514 4929.647051713742 6414.784530255319 5621.0329663477 5947.69815661029 5207.205022139424 4118.54355455117 4896.8330360369355 1.0513183948987992 1.0329987898997306 1.0279666278218489 1.006701068922571 1.3099863693631015 1.1478914892505439 1.2146009702270413 1.063382186776308 0.8410626877089433 1.0 12.25763329096239 -8.087326137228938 5.861985786786131 0.924898514052053 1.1133818901304087 0.38502429199482147 0.09585783202765256 0.2569413846057474 13.55039901441306 0.07122211508419654 0.026364910913093693 8.17850385588147e-09 8.087326137228938 0.18848337607835564 TATCHSSSS(ph)PPIDAASAEPYGFR ddPTM_A459_Selumetinib_30min_R2 8 TATCHSSSSPPIDAASAEPYGFR 23 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TATCHSS(0.001)S(0.315)S(0.684)PPIDAASAEPYGFR;T(0.001)AT(0.001)CHSS(0.002)S(0.174)S(0.822)PPIDAASAEPYGFR;TATCHSS(0.001)S(0.232)S(0.768)PPIDAASAEPYGFR;T(0.042)AT(0.042)CHS(0.033)S(0.033)S(0.202)S(0.648)PPIDAASAEPYGFR;TATCHSS(0.004)S(0.291)S(0.705)PPIDAASAEPYGFR;T(0.014)AT(0.021)CHS(0.013)S(0.267)S(0.267)S(0.419)PPIDAASAEPYGFR;TATCHSS(0.001)S(0.301)S(0.698)PPIDAASAEPYGFR;T(0.016)AT(0.016)CHS(0.029)S(0.029)S(0.103)S(0.807)PPIDAASAEPYGFR 114.62 7.2159000000000015e-06 994641200.0 667999.43 618211.2999999999 1214310.7999999998 1598873.5999999999 2167796.0 1162373.5 678803.7999999999 978501.0 1408438.9 1811235.6 True False 630874.6958941908 665626.1188473655 1136183.3651696348 1381104.2574692 1895458.0861378736 1322479.8986489424 710369.5217242115 981348.275910439 1690166.0350709106 1758940.5220727513 0.3586674409835998 0.37842446091524784 0.6459475752089366 0.7851909943161094 1.077613519247512 0.7518616360549362 0.4038621618013017 0.5579201022408702 0.9609000496953721 1.0 20.7462752687563 -5.362291398595724 2.799320138080595 0.7653997298197807 0.3557855121354535 0.42898903243530806 0.19127103132023449 0.2953809052297943 4.41285753904583 0.05704335136442067 0.15034247593496466 4.342187786058028e-06 5.362291398595724 -0.40961421768432715 TATES(ph)FASDPILYRPVAVALDTK ddPTM_A459_Selumetinib_30min_R1 3 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 1 T(0.017)AT(0.072)ES(0.852)FAS(0.058)DPILY(0.001)RPVAVALDTK;T(0.003)AT(0.018)ES(0.76)FAS(0.218)DPILY(0.001)RPVAVALDTK;T(0.108)AT(0.38)ES(0.443)FAS(0.004)DPILY(0.065)RPVAVALDTK 81.34100000000002 0.00027651 109096000.0 7721.200000000001 14594.900000000001 12112.0 14845.199999999999 12132.5 11396.1 12978.400000000001 12759.699999999999 4717.7 9708.0 True False 7901.088937160147 12886.122323015074 10467.256926453683 12252.76449891687 11035.117517166844 11281.46558083091 11999.428839030219 12421.271306653174 8005.592332824923 10954.116363927795 0.7212894837577816 1.1763725977432034 0.9555546589702705 1.1185534361553395 1.0073945857929525 1.0298836716744297 1.095426453433037 1.1339364028993484 0.7308295865093745 1.0 13.419185490642002 -4.744340332358908 24.991099494898407 1.033893846488511 0.7212885488685489 0.37329359163267795 0.11879154472178946 1080.6031745605708 1579270.4545399873 0.027679236319594624 0.7994206097104729 1.801605369905529e-05 4.744340332358908 -0.31260529761996214 TATESFASDPILYRPVAVALDTK ddPTM_A459_Selumetinib_30min_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 108.12 5.1679e-05 42993000.0 1593.8 1565.7 1458.6 1365.1 1366.4 1209.2 1477.8 1407.9 892.96 1081.5 False True 1630.932439005055 1382.3871161258169 1260.5301315162922 1126.7109111006528 1242.8093612575142 1197.0365458657564 1366.328356216395 1370.5579184962826 1515.287900782022 1220.321059702092 1.336478155513601 1.1328060801173823 1.0329495844511738 0.9232905571388798 1.0184281844328016 0.980919354254183 1.1196466252495443 1.123112567467177 1.2417124892951843 1.0 10.253045047452847 -4.803648932581237 2.7466635010145084 1.0537459567632579 1.3822156234176741 0.5017948443563813 0.08462242356063517 0.37942194171299093 4.041922475519045 0.02386187452619275 0.2810009317261572 1.571632740116129e-05 4.803648932581237 0.32846966665441624 TATESFASDPILYRPVAVALDTK ddPTM_A459_Selumetinib_30min_R2 2 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;H3BQ34;H3BUW1;H3BTJ2;H3BT25;P14618-2;H3BTN5 P14618;P14618-2 PKM Pyruvate kinase PKM;Pyruvate kinase 0 ; 150.13 2.2824e-07 193634000.0 649160.0 492450.0 549790.0 607390.0 556860.0 417678.0 490180.0 461760.0 389584.0 510990.0 False True 613082.2859933765 530219.3315236802 514417.1099660911 524662.4341938087 486902.2684084365 475209.35319662094 512974.3412732439 463103.6451515166 467511.68588645564 496236.3909885349 1.2354641802308715 1.0684813551610939 1.0366372142545592 1.057283270073457 0.9811901691419603 0.957626973406713 1.0337297920681834 0.9332319305099416 0.9421148758460504 1.0 18.92066801211292 -1.5228787458973565 0.5528236829697213 0.9713162445533531 12.440059997706424 0.8356900821937374 0.03386871918924932 52.64538853936298 0.47787745431466855 0.016968711949664508 717.7067700278875 0.029999999957377843 1.5228787458973565 11.46874375315307 TATGY(ph)S(ph)GY(ph)S(ph)QK ddPTM_A459_Selumetinib_30min_R2 1 TATGYSGYSQK 11 0 A0A0B4J1T8;Q9UF33 A0A0B4J1T8 EPHA6 Receptor protein-tyrosine kinase;Ephrin type-A receptor 6 4 TAT(0.124)GY(0.936)S(0.955)GY(0.991)S(0.994)QK 64.84100000000001 0.031859 0.0 1142.8 1306.3 748.98 2432.4 2067.6 1117.4 766.6 1150.2 1023.6 998.42 True False 1079.287750990866 1406.4890095834749 700.7914422277652 2101.102923875956 1807.8496034214772 1271.3117072527264 802.2484189890823 1153.5468915741392 1228.348601773625 969.5930203933033 1.1131348187232892 1.4505972918544217 0.7227686539487442 2.1669946871355057 1.8645447784763813 1.3111807536908988 0.827407378266461 1.1897227675032327 1.266870301186121 1.0 9.921235503395602 -7.005854334031027 24.83187643888256 1.0843079839448597 1.4735103390531255 0.19123928681701208 0.3801820759344395 445.0429736678998 1887710.1412842951 0.1444843975120436 0.12340155360591569 9.866103474294723e-08 7.005854334031027 0.38920235510826573 TATNDEESPLSVS(ph)SPEGTGTWLHYTSGVGTGR ddPTM_A459_Selumetinib_30min_R1 2 TATNDEESPLSVSSPEGTGTWLHYTSGVGTGR 32 0 A0A087WZV0;O43314;O43314-2;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 TATNDEESPLS(0.001)VS(0.5)S(0.5)PEGTGTWLHYTSGVGTGR;TATNDEESPLS(0.013)VS(0.493)S(0.493)PEGTGTWLHYTSGVGTGR 156.49 9.1101e-24 17998600.0 1112.93 1275.98 1039.97 1445.27 1624.32 1265.93 1694.6399999999999 1240.26 518.5 823.9399999999999 True False 1138.8591036151943 1126.587668412992 898.7477861463038 1192.880725577936 1477.4005427969873 1253.1958935724742 1566.8119404375082 1207.3642758677452 879.8566302583298 929.7007248552394 1.2249738794089058 1.2117745402300393 0.9667065563342923 1.2830803436919718 1.5891141130679751 1.3479562401842864 1.6852863491974488 1.2986590669333293 0.9463869466115876 1.0 9.86062257023947 -5.987688040222409 24.50787509363862 1.3548320175528095 1.1393271150471158 0.0935600031749102 0.2241441129968284 344.42913729158954 685603.6940339803 0.0639726756980765 0.09480831960163703 1.0287550018360987e-06 5.987688040222409 -0.21550490250569365 TATNDEESPLSVS(ph)SPEGTGTWLHYTSGVGTGR ddPTM_A459_Selumetinib_30min_R2 1 TATNDEESPLSVSSPEGTGTWLHYTSGVGTGR 32 0 A0A087WZV0;O43314;O43314-2;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 TATNDEESPLSVS(0.499)S(0.499)PEGT(0.001)GTWLHYTSGVGTGR 153.76 2.1576e-21 5754000.0 11181.0 11006.0 16282.0 19177.0 21362.0 16169.0 13607.0 18222.0 16248.0 17380.0 True False 10559.604781089318 11850.124810132224 15234.433846501206 16565.0595178298 18678.31458129696 18396.13298243184 14239.752461758986 18275.0230031855 19498.054007051447 16878.194241336914 0.6256359317886897 0.7020967196306884 0.9026104113193624 0.9814473800319108 1.106653609635047 1.08993490176676 0.8436774845785316 1.0827593723520237 1.155221567441033 1.0 14.042872941270895 -5.3377970085884625 1.5446531441975135 1.0421521079903955 0.6075583022318775 0.7787908436996208 0.07975650316854518 0.23286083807082295 0.9535269700789948 0.025230914363009505 0.11039081184478922 4.594126944509589e-06 5.3377970085884625 -0.434593805758518 TATNDEESPLSVSS(ph)PEGTGTWLHYTSGVGTGR ddPTM_A459_Selumetinib_30min_R2 1 TATNDEESPLSVSSPEGTGTWLHYTSGVGTGR 32 0 A0A087WZV0;O43314;O43314-2;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 TATNDEESPLSVS(0.064)S(0.936)PEGTGTWLHYTSGVGTGR 167.17 1.3784e-28 5725400.0 5680.5 7413.4 7749.8 10430.0 14533.0 10014.0 6760.7 9370.3 9169.6 10774.0 True False 5364.800550843205 7981.983942161932 7251.18630534425 9009.416007246431 12707.234613331557 11393.337601958836 7075.085946072905 9397.56602166333 11003.776220030719 10462.926625786191 0.5127437802747747 0.7628825306382343 0.6930361422466146 0.8610799185996831 1.2145009773856392 1.0889245437198822 0.6762052529964367 0.8981775709391626 1.051691999149797 1.0 13.352998829408229 -5.849701065857204 3.4326919170990746 0.9768868930479973 0.6617451658003276 0.5136602644716619 0.1437724544849522 0.22034989927101006 5.109947618152571 0.04506276626509554 0.07226187373118277 1.4135101590003617e-06 5.849701065857204 -0.31514172724766965 TATNNASSSCQST(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 TATNNASSSCQSTPR 15 0 Q92833-2;Q92833-3;Q92833 Q92833-2 JARID2 Protein Jumonji 1 TATNNAS(0.001)S(0.002)S(0.005)CQS(0.11)T(0.883)PR;TATNNASSSCQS(0.053)T(0.947)PR 187.78 5.6462e-05 2158800.0 283.44 1003.79 614.44 751.62 602.23 631.0 973.59 570.9300000000001 124.43 503.14 True False 290.0436005217673 886.265800150689 531.0024228773283 620.363676654804 547.7584028323425 624.6527129021601 900.1513224581946 555.7870817579961 211.14862199237027 567.7229199986228 0.5108893622305594 1.561088638367531 0.9353196853116593 1.0927226201406643 0.9648340476260343 1.1002774256562962 1.58554691161734 0.9789759443908735 0.3719219614964329 1.0 9.149043176765113 -8.012550014156686 24.75999373790058 0.6824568582140287 1.123957181380664 0.20927610166673627 0.3224449278351902 711.044098863403 1402814.855115444 0.1872089846597816 0.07850388489767461 9.715160635458539e-09 8.012550014156686 0.44150032316663523 TATNNASSSCQST(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 TATNNASSSCQSTPR 15 0 Q92833-2;Q92833-3;Q92833 Q92833-2 JARID2 Protein Jumonji 1 TATNNASSSCQS(0.011)T(0.989)PR;TATNNASSSCQS(0.067)T(0.933)PR;TATNNASSSCQS(0.221)T(0.777)PR 185.63 5.6586e-06 11573700.0 12324.7 11121.599999999999 19860.8 10447.6 11673.199999999999 8444.6 8516.630000000001 11612.400000000001 8500.34 16061.5 True False 11639.742513683166 11974.590958419636 18582.97775080403 9024.618856884745 10206.708256267935 9607.766997553585 8912.670170382187 11646.190161463699 10200.645519343901 15597.762762211336 0.7462443615236118 0.7677120841605856 1.19138738254341 0.5785841850825343 0.6543700152303703 0.615970837871076 0.5714069579244334 0.7466577315612786 0.6539813225045955 1.0 13.92905149303901 TATPPGYKPGS(ph)PPSFR ddPTM_A459_Selumetinib_30min_R1 1 TATPPGYKPGSPPSFR 16 1 P54259 P54259 ATN1 Atrophin-1 1 TATPPGYKPGS(0.72)PPS(0.28)FR 75.743 0.016712 62644000.0 2476.2 2832.9 3737.8 3436.2 2815.8 2492.6 2801.1 2688.3 1767.9 2152.4 True False 2533.890642153545 2501.2227510205216 3230.2272902657305 2836.1321754626506 2561.111387169868 2467.5267070997224 2589.810771821452 2616.997551170931 2999.997177692771 2428.681506151441 1.0433194454421573 1.029868570533166 1.3300333049369004 1.1677662008292176 1.054527479491652 1.0159943577821517 1.06634433756007 1.0775383863806418 1.2352369670927552 1.0 11.24595759405828 -6.260856543589322 24.769104154937384 1.0754400835430082 1.1480617456490279 0.10435149540038802 0.0968127104253485 116.96058515246887 4970480.805797689 0.030854836699927057 0.03751435520936155 5.484581020078894e-07 6.260856543589322 0.07262166210601961 TATPQQAQEVHEK ddPTM_A459_Selumetinib_30min_R1 2 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 ; 175.01 0.00015259 52620000.0 8548.9 8849.5 9335.5 10387.5 10943.599999999999 9055.6 10050.3 8760.9 4866.3 7501.700000000001 False True 8748.072736736305 7813.396425979068 8067.79037623087 8573.518122524376 9953.753312249502 8964.508885826946 9292.19777945705 8528.53247258618 8257.755679510337 8464.616267745894 1.0334872202146377 0.9230656392247485 0.9531194470058714 1.0128655394803245 1.175924932377373 1.0590567371595891 1.0977695249889383 1.0075509866978656 0.9755617287668679 1.0 13.047228951581776 -6.000764322838864 19.50767301341568 1.0591253902493176 0.9681717573420134 0.2805244484644094 0.05899268339004481 2.0918497484461582 53464.25466344703 0.01735724820188371 0.025192845574532094 9.982416293732361e-07 6.000764322838864 -0.09095363290730418 TATPQQAQEVHEK ddPTM_A459_Selumetinib_30min_R2 4 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 ;;; 188.09 0.00020487 67771700.0 343610.0 336800.0 361265.0 386335.0 393404.0 265813.0 306311.0 332991.0 255568.0 355097.0 False True 324513.53177981393 362631.47701731115 338021.60321559093 333715.50653495174 343981.0724436167 302426.3279398325 320555.0684437319 333959.94868037204 306688.7411665516 344844.42695719353 0.9410432833240964 1.051579926104839 0.9802147774235321 0.9677277068954249 0.9974963941821684 0.8769935202617426 0.9295643002620521 0.9684365544983199 0.889353914960098 1.0 18.395586125957607 -6.725327009413529 24.999206407969314 0.9306902972283945 0.9896505226815232 0.2967274588951193 0.04201314975955801 204.6380766592432 141662.51212604452 0.013286087147502916 0.013285677100208974 1.8822312977264069e-07 6.725327009413529 0.058960225453128734 TATSLPVVNFGS(ph)PLRR ddPTM_A459_Selumetinib_30min_R1 2 TATSLPVVNFGSPLRR 16 1 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 TATSLPVVNFGS(1)PLRR;TATSLPVVNFGS(1)PLRR 114.53 0.0010692 28368000.0 5239.7 5877.9 5879.9 7190.2 5373.1 4745.8 4691.3 4602.799999999999 3491.6 4864.1 True False 5361.774815318603 5189.712735438427 5081.44187597878 5934.566546770137 4887.104053697855 4698.061560841634 4337.431464012701 4480.718791998496 5924.990183625817 5488.454615346231 0.9769188580564337 0.9455690352121172 0.9258420142111762 1.0812818840073009 0.8904335366157637 0.8559898714850289 0.7902828333288643 0.8163898776661083 1.079537064414998 1.0 12.42218427130063 -6.462482956024612 24.999301729969282 0.887760533737862 0.9769976988370659 0.1333968591413306 0.08914081308708005 425.7415035022502 176224.34623971945 0.02779434309826006 0.03151577163115268 3.447601364894237e-07 6.462482956024612 0.08923716509920387 TATSLPVVNFGS(ph)PLRR ddPTM_A459_Selumetinib_30min_R2 2 TATSLPVVNFGSPLRR 16 1 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 TATSLPVVNFGS(1)PLRR;TATSLPVVNFGS(1)PLRR 104.81 0.0019389 13029400.0 59954.0 52834.0 65307.0 70258.0 74585.0 56706.0 48255.0 57008.0 45188.0 60925.0 True False 56621.99669487783 56886.19791191403 61105.21872088532 60688.739198189855 65214.96550163994 64516.73677418393 50498.9531154685 57173.88384181754 54226.86265821279 59165.93694783955 0.9570032964202959 0.9614687241759505 1.0327769975950085 1.0257378202544616 1.1022383632516999 1.0904371687895626 0.8535139595606873 0.9663310815515657 0.9165216585012246 1.0 15.852479205067198 -7.255670348096395 24.998855437576076 0.931285931659919 1.0286913172910586 0.40584174943598084 0.05578659391949659 507.9420801786843 2201062.971952057 0.023150405386612786 0.01743411874754078 5.5504686228686546e-08 7.255670348096395 0.09740538563113954 TATSLSLPSDPMGDS(ph)SPGSGKK ddPTM_A459_Selumetinib_30min_R2 2 TATSLSLPSDPMGDSSPGSGKK 22 1 Q6ZVF9 Q6ZVF9 GPRIN3 G protein-regulated inducer of neurite outgrowth 3 1 TATSLSLPS(0.001)DPMGDS(0.487)S(0.487)PGS(0.024)GKK;TATSLSLPSDPMGDS(0.5)S(0.5)PGS(0.001)GKK 113.51 1.93e-05 4997500.0 46454.0 28752.8 38202.0 34067.8 26173.7 24064.4 44393.0 31516.2 19736.7 26549.3 True False 43872.272650095976 30958.04730517625 35744.124911192695 29427.706869767037 22885.525810153184 27379.052665126666 46457.36246306066 31607.90692421222 23684.591489473933 25782.75272563442 1.70161321085301 1.200726998959902 1.3863579770384338 1.141371799315619 0.8876292633951116 1.0619134797777094 1.8018775170143324 1.2259322059427022 0.9186215196457903 1.0 14.654118682489184 -2.5396794032879155 1.305695741651875 1.1864425245853185 199.99999992754806 0.2743557192190933 0.2523969397818846 860.2430739076628 5.023760932041531 0.07686270596258328 508527.73003218195 0.002886161284679148 2.5396794032879155 198.81355740296274 TATYNGPPAS(ph)PSLSHEATPLSQTR ddPTM_A459_Selumetinib_30min_R1 1 TATYNGPPASPSLSHEATPLSQTR 24 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 TATYNGPPAS(1)PSLSHEATPLSQTR 136.48 5.1083e-08 9261000.0 3093.2 3239.7 3472.5 3569.5 3534.2 3778.2 3745.6 2778.4 1295.6 2021.6 True False 3165.265541680538 2860.3944179043306 3000.9535730771468 2946.1538328135516 3214.532234013688 3740.1947383311276 3463.06637640014 2704.7078064848847 2198.5385731199462 2281.0920520515483 1.3876097366758124 1.2539583465436104 1.3155775850335263 1.2915541177585823 1.4092075903392984 1.6396509448039611 1.518161607413238 1.1857074351963783 0.9638096678924659 1.0 11.155508951548281 -10.110413934110799 7.614454244229382 1.0000026246575924 1.3385155506488169 0.2418194669089847 0.17435569988962774 0.0 0.0 0.18335445988010007 0.04446998853021932 7.755076136041587e-11 10.110413934110799 0.3385129259912245 TATYNGPPAS(ph)PSLSHEATPLSQTR ddPTM_A459_Selumetinib_30min_R2 4 TATYNGPPASPSLSHEATPLSQTR 24 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 TATYNGPPAS(0.991)PS(0.009)LSHEATPLSQTR;TATY(0.001)NGPPAS(0.998)PS(0.001)LSHEATPLSQTR;TATYNGPPAS(0.99)PS(0.01)LSHEATPLSQTR;TATYNGPPAS(1)PSLSHEATPLSQTR 192.77 8.0574e-27 37198500.0 50875.1 35879.0 54959.1 59262.2 59209.1 40194.9 37629.8 39724.2 39625.9 48135.1 True False 48047.66561116156 38630.80393083171 51423.09134094364 51190.58612700285 51770.72352193003 45731.382622026686 39379.66026203412 39839.790845304655 47552.18724015389 46745.31459299058 1.0278605680485946 0.8264101817944416 1.1000694248970675 1.0950955528423982 1.1075061527063292 0.9783094417099948 0.8424301045978856 0.8522734565418584 1.01726103790698 1.0 15.51253414664143 -7.003995913152411 24.480305966095163 0.9149219052872565 1.028910826497987 0.2165797261994662 0.09138942670890671 194.2761506311254 1190209.597681765 0.03449327444554348 0.029728700762589367 9.908412689766937e-08 7.003995913152411 0.11398892121073045 TAVAPSAVNLADPRT(ph)PTAPAVNLAGAR ddPTM_A459_Selumetinib_30min_R2 4 TAVAPSAVNLADPRTPTAPAVNLAGAR 27 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 TAVAPSAVNLADPRT(0.721)PT(0.279)APAVNLAGAR;TAVAPSAVNLADPRT(0.733)PT(0.267)APAVNLAGAR;TAVAPSAVNLADPRT(0.882)PT(0.118)APAVNLAGAR;TAVAPS(0.006)AVNLADPRT(0.707)PT(0.288)APAVNLAGAR 99.097 2.1705e-06 43825800.0 49350.9 56330.7 57677.0 69122.0 66318.0 44506.9 39007.899999999994 33820.0 28907.699999999997 58708.0 True False 46608.17454530549 60651.08355825144 53966.12461396943 59707.4643578991 57986.53994955769 50637.32148158797 40821.84464268744 33918.41060079759 34690.0477486239 57012.94749829738 0.8175015779827448 1.063812453479321 0.9465591059922145 1.0472614902024175 1.0170766903656294 0.8881723135450976 0.7160100719912181 0.5949246984960833 0.6084591179864869 1.0 15.799001968483227 -7.143145550242528 2.920640184226201 0.6932184664618521 0.9839547723575128 0.46418871608492185 0.12341100407013361 0.204707378487726 3.3548490308048677 0.04992729732089075 0.03692763693070383 7.19207900964486e-08 7.143145550242528 0.2907363058956607 TAVIPINGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 TAVIPINGSPR 11 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TAVIPINGS(1)PR;TAVIPINGS(1)PR;TAVIPINGS(1)PR;TAVIPINGS(1)PR 148.89 0.00064087 253300000.0 14743.0 18516.100000000002 18246.300000000003 18728.7 16724.6 15387.0 16579.1 15893.6 8650.9 13409.7 True False 15086.48321511578 16348.226404098648 15768.552679751634 15458.084126240421 15211.862882967958 15232.220750278177 15328.52513909001 15472.050098311316 14679.945463262853 15130.965616539199 0.9970601743106999 1.0804483215683802 1.0421378965077752 1.0216191430204336 1.0053464708386048 1.0066919148655191 1.013056636804122 1.0225421490218236 0.9701922425371617 1.0 13.885216438864838 -5.961639248548779 2.730207724783003 1.004875869570413 1.0439711366642188 0.3428750535910946 0.02268748247861426 0.28953602447546206 4.382672940832935 0.00664674285956195 0.010249652910040152 1.0923473299259158e-06 5.961639248548779 0.03909526709380584 TAVIPINGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 TAVIPINGSPR 11 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TAVIPINGS(1)PR;TAVIPINGS(1)PR;TAVIPINGS(1)PR;TAVIPINGS(1)PR;TAVIPINGS(1)PR 101.72 0.014991 329395200.0 666430.0 566850.0 668023.0 807242.0 766854.0 501526.0 583254.0 676445.0 520283.0 599681.0 True False 629392.4885306645 610325.5722899728 625043.1274684499 697294.2470298768 670514.9447582578 570606.6541002609 610376.4666958748 678413.3429585017 624354.1379216375 582366.6513716427 1.080749536478887 1.0480091379760135 1.0732811125023929 1.1973457707228705 1.151362192836764 0.9798065407013201 1.0480965303529328 1.1649247795364674 1.0720980269922773 1.0 19.15156821788849 -6.712427432464129 24.999999453024078 1.0629858415683264 1.1094932123739547 0.17176081402958165 0.06080398384320201 276.26726972594423 140917.3023167746 0.02188611108993285 0.021886078738704056 1.938976598159431e-07 6.712427432464129 0.04650737080562828 TAVPS(ph)PVEAAAASDPAAAR ddPTM_A459_Selumetinib_30min_R1 3 TAVPSPVEAAAASDPAAAR 19 0 Q147X3;Q147X3-2;J3KNC2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 TAVPS(1)PVEAAAASDPAAAR;T(0.054)AVPS(0.946)PVEAAAASDPAAAR;T(0.04)AVPS(0.96)PVEAAAASDPAAAR 209.19 1.8132999999999998e-16 28356800.0 7916.3 9885.599999999999 9226.9 10189.1 9084.2 7851.7 8494.7 7830.1 4611.4400000000005 7312.5 True False 8100.734387561627 8728.189356309242 7973.937659733774 8409.764958095126 8262.535713945776 7772.719026773202 7853.937939877792 7622.420312250685 7825.276873748259 8251.130604781833 0.9817726534187878 1.0578173797480477 0.966405459042496 1.0192257717047115 1.001382248046993 0.9420186637536226 0.9518620315288849 0.9238031340617991 0.9483884389386861 1.0 13.01037610173636 -6.727668556359181 6.401131822521382 0.9483198349237935 1.00720750963814 0.44325525070343563 0.028923140087925254 0.1484790288552212 17.575502498020068 0.009167163484137484 0.008976979105500812 1.8721103472166745e-07 6.727668556359181 0.05888767471434664 TAVPS(ph)PVEAAAASDPAAAR ddPTM_A459_Selumetinib_30min_R2 4 TAVPSPVEAAAASDPAAAR 19 0 Q147X3;Q147X3-2;J3KNC2 Q147X3 NAA30 N-alpha-acetyltransferase 30 1 T(0.054)AVPS(0.946)PVEAAAASDPAAAR;T(0.037)AVPS(0.962)PVEAAAAS(0.002)DPAAAR;T(0.026)AVPS(0.974)PVEAAAASDPAAAR;T(0.002)AVPS(0.998)PVEAAAASDPAAAR 180.03 5.231e-13 44157000.0 211345.0 191646.0 231647.0 228937.0 259717.0 174872.0 173396.0 189477.0 153016.0 203763.0 True False 199599.29098106798 206344.6319609849 216743.08421818362 197755.38566164675 227089.028560561 198959.03067003656 181459.25757765572 190028.34670039391 183623.47562426067 197879.83275014572 1.008689406126057 1.0427774730410617 1.0953268011493404 0.9993710976668547 1.1476107767247634 1.0054538044877646 0.9170174396032387 0.9603219492323629 0.9279544715206731 1.0 17.594265059667386 -7.000770255922593 24.999067537766326 0.9499053321065916 1.058593335837033 0.5657346568502921 0.044387729029557975 19.82384679221687 643421.01236049 0.015041509451853839 0.013110203936212301 9.982279920580982e-08 7.000770255922593 0.10868800373044141 TAVSVTQGGHS(ph)R ddPTM_A459_Selumetinib_30min_R2 3 TAVSVTQGGHSR 12 0 P40425 P40425 PBX2 Pre-B-cell leukemia transcription factor 2 1 TAVSVTQGGHS(1)R;TAVSVTQGGHS(1)R;TAVSVTQGGHS(1)R 109.14 0.0051363 8031100.0 51134.0 45802.0 78592.0 92536.0 104626.0 67588.0 56271.0 65217.0 61976.0 76340.0 True False 48292.17698562035 49314.86612335778 73535.4762844997 79932.43716649641 91481.9465116924 76897.63349722323 58887.71299887118 65406.77067274442 74372.93175412477 74135.86584485954 0.6514009978203937 0.6651957937141594 0.9919014966168165 1.0781884888721347 1.2339769080613714 1.0372527874449204 0.7943215112925583 0.8822554363851085 1.0031977222706392 1.0 16.17788404567205 -5.262175218130153 5.885039869166086 1.0039290636478986 0.6549087110242693 0.6161351422709553 0.1087760520283541 0.10788225197913527 16.558547138273568 0.03279954664752887 0.07869234718313879 5.467953112721042e-06 5.262175218130153 -0.3490203526236293 TCDSITPSKSS(ph)PVPVSDTQK ddPTM_A459_Selumetinib_30min_R2 2 TCDSITPSKSSPVPVSDTQK 20 1 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 TCDSITPS(0.011)KS(0.205)S(0.776)PVPVS(0.008)DTQK;TCDSIT(0.001)PS(0.002)KS(0.064)S(0.925)PVPVS(0.007)DT(0.001)QK 131.31 8.6504e-05 92956000.0 154582.0 136867.0 156737.0 173337.0 170837.0 112738.0 126078.0 128275.0 91255.0 146601.0 True False 145990.9512807755 147364.2588032319 146652.71206234247 149728.20157699703 149374.92875784237 128266.6361663307 131940.8768188174 128648.25901293052 109508.54987773782 142368.2482148581 1.0254460043678428 1.0350921687315697 1.0300942373120894 1.0516965928458395 1.0492151911036371 0.9009497396691597 0.9267577460087589 0.9036302730843344 0.769192226854338 1.0 17.119267898474398 -6.7655057143669355 24.05444005501892 0.8957485766569345 1.0384175474953883 0.6259515526276784 0.053363967788246355 41.06952721632352 242944.51840099526 0.017999829216086845 0.01646529766908131 1.715909132355613e-07 6.7655057143669355 0.14266897083845376 TCDSITPSKSSPVPVS(ph)DTQK ddPTM_A459_Selumetinib_30min_R1 1 TCDSITPSKSSPVPVSDTQK 20 1 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 TCDSITPSKS(0.004)S(0.049)PVPVS(0.853)DT(0.094)QK 105.5 0.00027208 15755000.0 3441.2 4879.4 4812.2 5604.7 4051.5 4282.7 3644.3 3402.1 1969.5 3280.3 True False 3521.3732645904124 4308.117579628479 4158.7296715224875 4625.944358249087 3685.042540350421 4239.619926380475 3369.4075169572366 3311.8652564217637 3342.09765341134 3701.3584578278083 0.9513732065434639 1.1639287652665653 1.1235684732796978 1.2497963682674182 0.9955919110069219 1.1454226805335013 0.9103164568758408 0.894770202388173 0.9029381216356697 1.0 11.853839144776925 -7.2664589027471305 24.89599859068999 0.9182370327922348 1.1100877167969059 0.5201263082178622 0.08347449497308235 305.039383360652 1512936.3914928723 0.033430669338014835 0.023341531127544217 5.414284807933742e-08 7.2664589027471305 0.1918506840046711 TCDSITPSKSSPVPVSDT(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 TCDSITPSKSSPVPVSDTQK 20 1 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 T(0.004)CDS(0.008)IT(0.036)PS(0.03)KS(0.096)S(0.096)PVPVS(0.303)DT(0.428)QK 63.46 0.027954000000000003 16237000.0 2920.6 4001.2 4355.0 4790.2 3175.8 3448.0 3359.0 3451.5 1819.8 2389.7 True False 2988.6442975016716 3532.7376438925853 3763.614920302654 3953.681493190498 2888.5494507330286 3413.3162505335163 3105.6279256535836 3359.9550079479486 3088.0676870667485 2696.441272649182 1.108366174266947 1.310148186695631 1.3957711441662521 1.4662590775826951 1.0712450814458516 1.2658596666487099 1.1517506267074702 1.2460701599656505 1.1452382510199468 1.0 11.396840897564731 -6.2720977422003825 24.991285396217208 1.1652085938243075 1.3248252247072734 0.3582671923518307 0.1120174100281134 879.3550609695214 2061871.603420865 0.03492114304926919 0.04001458076553111 5.344440640220069e-07 6.2720977422003825 0.15961663088296585 TCEERPAEDGS(ph)DEEDPDSMEAPTR ddPTM_A459_Selumetinib_30min_R1 2 TCEERPAEDGSDEEDPDSMEAPTR 24 1 D6RGJ8;Q9H6Y2 D6RGJ8 WDR55 WD repeat-containing protein 55 1 T(0.001)CEERPAEDGS(0.999)DEEDPDSMEAPTR;T(0.037)CEERPAEDGS(0.963)DEEDPDSMEAPTR 80.009 0.00014549 194810000.0 3767.3 4567.0 4518.4 5149.5 4614.1 3833.0 4397.1 4021.9 2249.75 3556.7 True False 3855.070760110271 4032.2935168593012 3904.826097794606 4250.2364930868125 4196.7554696855195 3794.4435000855447 4065.4232068744823 3915.226147027626 3817.6614347611917 4013.237090191802 0.9605888397503144 1.00474839294047 0.972986646450032 1.059054423541093 1.0457282675728852 0.9454820173368325 1.0130034970548392 0.9755780829884906 0.9512673557441722 1.0 11.970550673458824 -10.304063100479443 10.795219290812405 0.9999999999830671 0.9941733499418243 0.0012066865040345487 0.036699072344839434 0.0 0.0 0.03651413821108718 0.00885597933368908 4.9652017469606175e-11 10.304063100479443 -0.005826650041242831 TCEERPAEDGS(ph)DEEDPDSMEAPTR ddPTM_A459_Selumetinib_30min_R2 3 TCEERPAEDGSDEEDPDSMEAPTR 24 1 D6RGJ8;Q9H6Y2 D6RGJ8 WDR55 WD repeat-containing protein 55 1 T(0.004)CEERPAEDGS(0.993)DEEDPDS(0.003)MEAPT(0.001)R;TCEERPAEDGS(0.998)DEEDPDS(0.001)MEAPTR;T(0.011)CEERPAEDGS(0.989)DEEDPDSMEAPTR 80.844 0.00012975 518800000.0 110904.0 119391.0 139663.0 146318.0 136998.0 106529.0 114981.0 105496.0 100847.0 126428.0 True False 104740.39966388773 128547.9057974284 130677.23463357691 126389.2359873717 119787.0864623407 121202.40277602093 120327.84433052904 105802.97589419715 121019.21790061046 122777.69514060688 0.8530898022147869 1.0469972225021278 1.064340183971717 1.0294152846136169 0.9756420848685806 0.9871695558156397 0.9800464505603218 0.8617442750739862 0.9856775513012963 1.0 16.90568896647369 -7.537519096592001 24.84723014467948 0.9384056127040131 0.9980655605112264 0.07391297629327098 0.06427628609813943 440.8359170758033 748165.1818585275 0.02997399388831615 0.01731491189611939 2.9005536541125952e-08 7.537519096592001 0.05965994780721329 TCEERPAEDGSDEEDPDS(ph)MEAPTR ddPTM_A459_Selumetinib_30min_R1 1 TCEERPAEDGSDEEDPDSMEAPTR 24 1 D6RGJ8;Q9H6Y2 D6RGJ8 WDR55 WD repeat-containing protein 55 1 T(0.014)CEERPAEDGS(0.293)DEEDPDS(0.624)MEAPT(0.069)R 62.823 0.0090824 10702000.0 1539.4 2046.8 2049.1 1774.2 1682.2 1701.1 1529.7 1532.1 959.63 1508.1 True False 1575.2650248490297 1807.1597044684952 1770.8434749006126 1464.3692758587483 1530.0453070165315 1683.9884784752214 1414.3134974314646 1491.463731037825 1628.4220213978795 1701.6793251379804 0.9257120313906967 1.0619860497640834 1.0406446436416708 0.860543613726993 0.8991384477756806 0.9896038892866466 0.8311280959570836 0.8764657999925397 0.9569499948328039 1.0 10.73274347702003 -5.753540041863388 24.99900176900034 0.9099094048943341 1.014701439167767 0.3234071589834906 0.061144356139000475 185.48102023974565 586984.3887253024 0.016380189606286098 0.027732006505926794 1.7638431309992299e-06 5.753540041863388 0.10479203427343275 TCFS(ph)PNR ddPTM_A459_Selumetinib_30min_R1 2 TCFSPNR 7 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 1 T(0.007)CFS(0.993)PNR;TCFS(1)PNR 120.87 0.0091095 73314000.0 9926.3 16095.6 8588.7 10840.3 9453.0 9962.9 11099.9 9081.1 5066.9 8656.3 True False 10157.56347678246 14211.119669358564 7422.401714352108 8947.245102633075 8597.9778190627 9862.682271589434 10262.625606419242 8840.239728429991 8598.159228266017 9767.420424502287 1.0399433049182025 1.4549511592343187 0.7599142242031961 0.9160294851431047 0.8802710895390604 1.009753020034663 1.0506996894159175 0.9050741489793565 0.8802896624268274 1.0 13.253761881434631 -5.2658040075016785 24.999965810644234 0.9274257654478214 1.2474472315127882 0.5312972821632904 0.1210338996094667 246.58980107162037 1412439.5857150415 0.030335041845165823 0.06681548598810647 5.422455448617791e-06 5.2658040075016785 0.32002146606496684 TCFS(ph)PNRVIGLSSDLQQVGGASAR ddPTM_A459_Selumetinib_30min_R1 2 TCFSPNRVIGLSSDLQQVGGASAR 24 1 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 1 T(0.066)CFS(0.933)PNRVIGLSSDLQQVGGASAR;T(0.242)CFS(0.755)PNRVIGLS(0.002)S(0.002)DLQQVGGASAR 73.994 0.00027592 122999000.0 2561.2 2088.35 4321.9 5268.799999999999 2981.8999999999996 2556.2 2386.4 2143.03 1498.04 1936.66 True False 2620.8709767723367 1843.8450111524241 3735.009718497369 4348.702987625167 2712.1876714972022 2530.4869488439003 2206.3919266983366 2086.1898828575104 2542.064467487346 2185.249175665885 1.1993465120396212 0.8437687709414516 1.7091916839914805 1.9900261425793873 1.241134284226763 1.1579855409728343 1.0096752129083901 0.9546691087170004 1.1632835723243016 1.0 11.093582078805067 -6.70946894333123 3.2091286727037143 1.0428483142688942 1.4289496710716445 0.2713314947894302 0.2887578888622443 0.3768176037454305 7.909782769684573 0.1150980679519835 0.11049440457709443 1.9522303342583553e-07 6.70946894333123 0.38610135680275026 TCGVNDDES(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 TCGVNDDESPSK 12 0 Q8NG08 Q8NG08 HELB DNA helicase B 1 TCGVNDDES(0.971)PS(0.029)K;TCGVNDDES(0.767)PS(0.233)K 177.93 0.00010371 8050500.0 5158.7 7175.9 4559.9 4708.7 4302.0 5434.6 6183.1 5930.0 3317.4 6271.6 True False 5278.88767291717 6335.742292014593 3940.6906257377923 3886.413938246023 3912.884859579791 5379.932858221998 5716.703788957634 5772.717136645322 5629.385506690419 7076.620950557231 0.7459616262902279 0.895306154770901 0.5568604922138005 0.5491906328457506 0.5529312488146876 0.7602403598850902 0.8078295882878236 0.8157448557691598 0.7954906085858883 1.0 12.788844930059703 -7.069980807798421 3.2980430321118326 0.8392258364176407 0.660852565312013 0.3909161418180679 0.11306733923460793 0.32225021973799484 6.832531669501016 0.04974768497151228 0.03867225090043634 8.511756522509697e-08 7.069980807798421 -0.17837327110562773 TCGVNDDES(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 TCGVNDDESPSK 12 0 Q8NG08 Q8NG08 HELB DNA helicase B 1 TCGVNDDES(0.99)PS(0.01)K;T(0.023)CGVNDDES(0.968)PS(0.009)K 100.4 0.013485 8658200.0 37453.0 28292.0 32381.0 33816.0 34107.0 34543.0 52468.0 41969.0 35132.0 30037.0 True False 35371.51219623811 30461.905426881793 30297.641713767083 29210.202464146238 29822.173739551305 39300.9846998666 54907.86596336961 42091.12284165804 42159.38167009674 29169.75376450154 1.2126092143871254 1.044297654097881 1.0386663513984866 1.0013866657898882 1.0223663175327773 1.3473197277275057 1.8823561695673396 1.4429714827720386 1.445311537782094 1.0 14.832185587375122 -6.89102638451378 4.570046395703688 1.4960024404076184 1.0593727908992483 0.42230178413913255 0.20799065701531358 0.17835739881199825 6.362108049041756 0.07269397310240562 0.06388298106572435 1.2852085778244227e-07 6.89102638451378 -0.43662964950837013 TCGVNDDES(ph)PSKIFMVGESPQVSSR ddPTM_A459_Selumetinib_30min_R1 1 TCGVNDDESPSKIFMVGESPQVSSR 25 1 Q8NG08 Q8NG08 HELB DNA helicase B 1 T(0.004)CGVNDDES(0.898)PS(0.097)KIFMVGES(0.001)PQVS(0.001)SR 70.767 0.00058518 11032000.0 639.54 601.85 771.91 647.81 444.35 630.09 497.95 415.59 265.05 586.42 True False 654.4400376717863 531.3851222075257 667.0888617981224 534.6821443997612 404.1586209563645 623.7518666759458 460.3892305981549 404.5672031734285 449.7704915139253 661.6927192145174 0.9890392000212113 0.8030693202100253 1.008155058121254 0.8080520290966358 0.6107950249719134 0.9426609188270797 0.6957749680919476 0.6114125052693377 0.67972712779406 1.0 9.370017595049694 -5.976730282585369 9.454394328940975 0.7404457822458842 0.9186514193443783 0.25748703759630964 0.1318056787542137 0.37912861453065844 142.91894487653715 0.03614221282684405 0.053243715099961966 1.0550419239050528e-06 5.976730282585369 0.17820563709849413 TCGVNDDES(ph)PSKIFMVGESPQVSSR ddPTM_A459_Selumetinib_30min_R2 1 TCGVNDDESPSKIFMVGESPQVSSR 25 1 Q8NG08 Q8NG08 HELB DNA helicase B 1 T(0.006)CGVNDDES(0.831)PS(0.163)KIFMVGESPQVSSR 62.605 0.0023287 4410000.0 19316.0 18194.0 16308.0 15330.0 16855.0 14121.0 14695.0 15764.0 9652.9 17805.0 True False 18242.494048074517 19589.421297069384 15258.761034807865 13242.027554274953 14737.524214388166 16066.039572324822 15378.34661759008 15809.87063012931 11583.749724560985 17290.92338705431 1.0550329580277156 1.1329308943521175 0.8824723060326598 0.765836922520242 0.8523271941290382 0.9291603006206969 0.8893883960589303 0.9143450743623176 0.6699323954690426 1.0 14.077727294819558 -5.303916391633698 6.3993853167668115 0.8585647468968204 1.0939858334980845 0.5266954747206759 0.0876010922669855 0.13797713648868812 15.743428935512146 0.022337176647930702 0.04820105171213162 4.966879323117459e-06 5.303916391633698 0.23542108660126415 TCGVNDDESPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 TCGVNDDESPSK 12 0 Q8NG08 Q8NG08 HELB DNA helicase B 1 TCGVNDDES(0.282)PS(0.718)K 164.53 3.1319e-05 0.0 72308.0 65959.0 61137.0 67540.0 79605.0 92402.0 100810.0 98762.0 72729.0 79446.0 True False 68289.41083185817 71017.84320838742 57203.511980932584 58340.935487001414 69604.30822227051 105129.53675815865 105497.86475122531 99049.38106907069 87276.83221804796 77152.1875545025 0.8851260475746925 0.9204903381154086 0.7414373304777963 0.7561799261464586 0.9021689524111037 1.3626254820563857 1.3673995267690708 1.2838181807754887 1.1312295216048558 1.0 16.23541944275233 -6.669542164880642 5.483074554285195 1.2543678072560382 0.8279489189859418 0.74096542071669 0.11464042902043765 0.10094380004784398 4.776398649289491 0.038874498356405045 0.03860946783730358 2.1402171268010557e-07 6.669542164880642 -0.42641888827009644 TCLS(ph)PGSSEMSLQPDLVR ddPTM_A459_Selumetinib_30min_R2 1 TCLSPGSSEMSLQPDLVR 18 0 Q6UB98-2;Q6UB98 Q6UB98-2 ANKRD12 Ankyrin repeat domain-containing protein 12 1 T(0.26)CLS(0.696)PGS(0.038)S(0.006)EMS(0.001)LQPDLVR 65.28699999999999 0.033664 2701200.0 6069.5 6805.7 6121.7 6592.4 7735.0 5891.5 4528.2 4374.2 4527.2 7141.4 True False 5732.181488133583 7327.67530622541 5727.836486802999 5694.503747475687 6763.260148222633 6703.000647287845 4738.770272458075 4386.928197812205 5432.766500536888 6935.2092264144685 0.8265333173080265 1.0565903734116826 0.8259068039342072 0.821100497701894 0.9752063603882454 0.9665174371030942 0.6832916092003815 0.6325588824492128 0.7833601443262658 1.0 12.759723692136317 -7.259845082288274 24.984187706134005 0.7441825639995108 0.913380383492703 0.2360071628763799 0.11576256985002492 168.78936495012644 2645121.440264113 0.04473286551195846 0.03277943710481686 5.497369362164363e-08 7.259845082288274 0.16919781949319224 TCNS(ph)PQNSTDSVSDIVPDSPFPGALGSDTR ddPTM_A459_Selumetinib_30min_R1 3 TCNSPQNSTDSVSDIVPDSPFPGALGSDTR 30 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 T(0.07)CNS(0.93)PQNSTDSVSDIVPDSPFPGALGSDTR;T(0.224)CNS(0.754)PQNS(0.016)T(0.003)DS(0.003)VSDIVPDSPFPGALGSDTR;T(0.064)CNS(0.677)PQNS(0.232)T(0.017)DS(0.01)VSDIVPDSPFPGALGSDTR 188.22 9.6198e-40 113298000.0 5680.4 6168.799999999999 6745.799999999999 6486.900000000001 5858.7 5567.1 5040.4 4919.2 2987.13 4723.0 True False 5812.7422678656785 5446.554028202684 5829.757412027014 5354.084689194068 5328.781619437495 5511.100028522371 4660.198569950676 4788.726836186456 5068.941438656827 5329.243055915844 1.0907256822173115 1.0220126894299963 1.0939184703830618 1.0046613811788239 0.9999134142553627 1.034124353252129 0.874457877235965 0.8985754235529987 0.9511559869707832 1.0 12.379714917641435 -7.242705138370104 22.77062739234491 0.9225952892000202 1.0389352139241934 0.6087466925581682 0.04291117826715614 164.16426942724453 199534.24118555625 0.01632887324768705 0.012615445535139937 5.7186677040526994e-08 7.242705138370104 0.1163399247241732 TCNS(ph)PQNSTDSVSDIVPDSPFPGALGSDTR ddPTM_A459_Selumetinib_30min_R2 8 TCNSPQNSTDSVSDIVPDSPFPGALGSDTR 30 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 T(0.044)CNS(0.949)PQNS(0.007)TDSVSDIVPDSPFPGALGSDTR;T(0.452)CNS(0.537)PQNS(0.009)T(0.002)DSVSDIVPDSPFPGALGSDTR;T(0.093)CNS(0.9)PQNS(0.005)T(0.001)DSVSDIVPDSPFPGALGSDTR;T(0.061)CNS(0.598)PQNS(0.17)T(0.17)DS(0.002)VSDIVPDSPFPGALGSDTR;T(0.093)CNS(0.905)PQNS(0.001)T(0.001)DSVSDIVPDSPFPGALGSDTR;T(0.033)CNS(0.541)PQNS(0.355)T(0.066)DS(0.004)VSDIVPDSPFPGALGSDTR;T(0.066)CNS(0.548)PQNS(0.069)T(0.221)DS(0.091)VS(0.004)DIVPDSPFPGALGSDTR;T(0.083)CNS(0.917)PQNSTDSVSDIVPDSPFPGALGSDTR 160.16 3.0731e-22 18266800.0 33448.9 30534.059999999998 32962.3 39602.8 38026.2 27970.66 27900.72 24793.11 22656.960000000003 28854.7 True False 31589.944044555796 32875.92421952262 30841.541504638688 34208.83032135945 33249.00879745879 31823.364522628934 29198.15876422784 24865.253845379673 27188.985088355785 28021.58983748586 1.1273430318466933 1.173235509126712 1.1006349633802877 1.220802621113118 1.1865496922298089 1.1356730544980447 1.0419879433524513 0.8873605669624142 0.9702870267547683 1.0 14.774251190621142 -7.414157237601597 2.739741147660818 0.9472867666990569 1.1611449169652108 0.8302820451523599 0.041695808203737146 0.10251720130348999 1.4915431963958166 0.020316115273953814 0.012249910625650163 3.8533881934798264e-08 7.414157237601597 0.21385815026615396 TCNSPQNST(ph)DSVSDIVPDSPFPGALGSDTR ddPTM_A459_Selumetinib_30min_R2 1 TCNSPQNSTDSVSDIVPDSPFPGALGSDTR 30 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 T(0.064)CNS(0.079)PQNS(0.163)T(0.601)DS(0.046)VS(0.046)DIVPDSPFPGALGSDTR 75.512 6.0822e-05 2028000.0 2770.6 2957.5 3393.8 2480.4 2780.6 2311.7 1280.7 4011.6 751.91 2756.6 True False 2616.6211435905607 3184.3307401386555 3175.4466028900533 2142.5652410713387 2431.2761691206038 2630.115691476757 1340.2550876589066 4023.273091843869 902.3130101207568 2677.009795493057 0.9774417516125025 1.1895103056775178 1.1861916262824854 0.8003576395867154 0.9082059293222745 0.9824826550521968 0.5006537853971714 1.5028981584667136 0.3370600330412937 1.0 11.386406702640928 -5.759647320067471 24.988252761938245 0.8745506230735617 1.1248941634800227 0.13322066344445094 0.2978614888422492 93.81304086197578 1308073.504454343 0.0760217660942665 0.1234598533241689 1.7392126274883123e-06 5.759647320067471 0.250343540406461 TCNVLVALEQQS(ph)PDIAQGVHLDR ddPTM_A459_Selumetinib_30min_R1 2 TCNVLVALEQQSPDIAQGVHLDR 23 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 TCNVLVALEQQS(1)PDIAQGVHLDR;TCNVLVALEQQS(1)PDIAQGVHLDR 170.83 1.2462e-12 11661600.0 3067.0 3584.9 3156.7 2357.0 3392.0 2809.0 3581.5 3431.5 1803.93 3215.0 True False 3138.455132656861 3165.1782414252048 2728.0374785119157 1945.394196369672 3085.194198906239 2780.7440103679337 3311.3445715178095 3340.485472917107 3061.1374561656876 3627.6765667519417 0.865141937244668 0.8725083902006079 0.7520068088524434 0.5362645099619481 0.8504601063894136 0.766535814094829 0.9128003863041844 0.9208333244294784 0.8438286599807028 1.0 11.824830119706178 -7.262364529373382 22.520802950098826 0.9127683929262175 0.7699996511749019 0.35122411315879976 0.09665863812230557 26.909287762174788 655004.2523578553 0.04121894968876889 0.02963367452902728 5.46557012268773e-08 7.262364529373382 -0.1427687417513156 TCNVLVALEQQS(ph)PDIAQGVHLDR ddPTM_A459_Selumetinib_30min_R2 3 TCNVLVALEQQSPDIAQGVHLDR 23 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 TCNVLVALEQQS(1)PDIAQGVHLDR;TCNVLVALEQQS(1)PDIAQGVHLDR;TCNVLVALEQQS(1)PDIAQGVHLDR 107.95 1.2266e-05 7604400.0 52398.0 40937.0 55216.0 59181.0 56036.0 44550.0 43624.0 50849.0 42331.0 47065.0 True False 49485.92892581324 44076.73626679837 51663.46267463524 51120.44570708067 48996.256711803966 50686.35811536509 45652.60243931608 50996.962171494866 50798.382826962996 45706.11116044433 1.082698301592547 0.9643510495144448 1.1303403716251101 1.118459750986693 1.0719848061413513 1.1089623866147431 0.9988292873804027 1.1157580655347774 1.111413365460978 1.0 15.480099454054471 -5.269415844194979 24.993466323705192 1.0850442268758884 1.0235246736075658 0.1652805586685674 0.052171076706394835 890.3738960312832 2789905.167238191 0.013094068940510779 0.02811861785035897 5.3775462691475995e-06 5.269415844194979 -0.06151955326832259 TCPSLS(ph)PTSPLNNK ddPTM_A459_Selumetinib_30min_R1 1 TCPSLSPTSPLNNK 14 0 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 TCPS(0.002)LS(0.925)PT(0.071)S(0.003)PLNNK 160.46 0.00029051 15647000.0 1228.9 1433.4 1529.9 1691.2 1245.5 1244.8 1109.5 1236.3 863.71 1146.7 True False 1257.5309789768557 1265.5768616304185 1322.1479831391587 1395.8636677557863 1132.8447449108849 1232.2784421879692 1025.8095217364253 1203.509307931638 1465.6527871174976 1293.8901148038733 0.9718993634691082 0.9781177297441935 1.0218394653548835 1.0788116021485874 0.8755339668721408 0.952382608143472 0.7928103862915102 0.930148004194363 1.1327490413199888 1.0 10.337499384558937 -2.426229336592108 11.418094735391852 0.96757000737123 1.1696531551816185 0.0 0.09188487539079862 0.0 0.0 0.021794909082097396 0.0 0.003747750436425621 2.426229336592108 0.2020831478103885 TCPSLS(ph)PTSPLNNK ddPTM_A459_Selumetinib_30min_R2 2 TCPSLSPTSPLNNK 14 0 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 T(0.004)CPS(0.258)LS(0.568)PT(0.129)S(0.041)PLNNK;TCPS(0.008)LS(0.987)PT(0.005)SPLNNK 225.31 1.0095e-09 30303000.0 110293.0 87159.0 106902.0 111985.0 112358.0 87666.0 96830.0 110094.0 77434.0 98797.0 True False 104163.35659786114 93843.81503964335 100024.04170609705 96732.4498150999 98242.58354673561 99741.19574728614 101332.78686500496 110414.35531295728 92922.96368673207 95944.47390456621 1.085662908543019 0.9781054730988223 1.0425200914185917 1.0082128326777575 1.0239524961537156 1.039572074223852 1.0561607432002638 1.1508151623488387 0.968507720196167 1.0 16.54991209373386 -7.013568453870028 3.3762260740405785 1.0559676284479287 1.024859609175488 0.0 0.05124046349753647 0.7039556785718275 16.775733331467727 0.019229361159655567 0.0155212769987963 9.692404847401401e-08 7.013568453870028 -0.031108019272440668 TCPSLSPTS(ph)PLNNK ddPTM_A459_Selumetinib_30min_R1 2 TCPSLSPTSPLNNK 14 0 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 TCPS(0.001)LS(0.012)PT(0.388)S(0.598)PLNNK;TCPSLS(0.004)PT(0.137)S(0.859)PLNNK 222.55 4.8087e-09 26259000.0 9971.3 10427.1 13317.099999999999 13602.5 11635.2 10985.9 10657.7 11294.5 5954.4 8957.5 True False 10203.611889227697 9206.290284572726 11508.710965594142 11227.078725548774 10582.798214361399 10875.391820399109 9853.781108436506 10994.933170293527 10104.18190783066 10107.282378438742 1.0095307034257248 0.9108571364555869 1.1386553313425758 1.1107910420608043 1.047046853755372 1.0759956448430616 0.9749189484857952 1.0878228942874255 0.9996932438916819 1.0 13.303107520588968 -5.249475011450764 24.987965272247138 1.057190975264685 0.9601939239306165 0.3266486455004243 0.05396106856978515 837.3673548647339 1748859.5315980513 0.013599083447489682 0.03538270509655727 5.630215117409492e-06 5.249475011450764 -0.09699705133406855 TCPSLSPTS(ph)PLNNK ddPTM_A459_Selumetinib_30min_R2 4 TCPSLSPTSPLNNK 14 0 O75925;O75925-2 O75925 PIAS1 E3 SUMO-protein ligase PIAS1 1 TCPSLS(0.028)PT(0.336)S(0.635)PLNNK;TCPSLS(0.022)PT(0.156)S(0.823)PLNNK;TCPSLS(0.039)PT(0.046)S(0.915)PLNNK;TCPSLS(0.003)PT(0.129)S(0.868)PLNNK 255.39 2.9991e-28 44430500.0 167833.0 141588.0 169479.0 188844.0 169416.0 123355.0 142589.0 149612.0 117307.0 153914.0 True False 158505.51374873123 152447.34432282366 158574.90565478348 163123.12142592974 148132.44748174358 140346.0315448004 149219.6710347433 150047.34615040006 140771.67783143694 149470.10290340203 1.0604496194879087 1.0199186416653887 1.0609138722361462 1.0913428053993597 0.9910506824062139 0.9389572149789832 0.9983245353833698 1.0038619311540253 0.94180491681613 1.0 17.18949741901809 -6.395412861439839 6.001190238962103 0.976895292348065 1.0552679215407148 0.6828929460757602 0.026519872930929538 0.14372139127700195 6.4233191309128435 0.008417130575499802 0.009539496844632423 4.0233437385848855e-07 6.395412861439839 0.07837262919264976 TCS(ph)FGGFDLTNR ddPTM_A459_Selumetinib_30min_R1 1 TCSFGGFDLTNR 12 0 O94885;A0A1B0GWB9 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 T(0.004)CS(0.996)FGGFDLTNR 181.98 0.00010415 13609000.0 1561.2 2156.6 1958.4 2174.3 1757.9 2028.8 1608.3 1684.2 1132.5 1662.0 True False 1597.5729224336126 1904.1042694238608 1692.4600367211758 1794.5993216659222 1598.8982553824533 2008.3921140030131 1486.984636150242 1639.5295449473952 1921.7697854726307 1875.3338892509275 0.8518871927770355 1.015341470837721 0.9024846436264223 0.9569492301889486 0.8525939111680576 1.0709517518532305 0.792917274450895 0.8742600740832766 1.0247614019497355 1.0 10.872931764261214 -8.273853330333107 24.289952417619936 1.0123807302597447 0.9181131641600024 0.19888053691464858 0.07819705348409692 969.2752458787529 1896519.0435173272 0.07014411215966335 0.018662284428102527 5.322879928908294e-09 8.273853330333107 -0.0942675660997423 TCS(ph)FGGFDLTNR ddPTM_A459_Selumetinib_30min_R2 1 TCSFGGFDLTNR 12 0 O94885;A0A1B0GWB9 O94885 SASH1 SAM and SH3 domain-containing protein 1 1 T(0.024)CS(0.976)FGGFDLTNR 89.189 0.02612 4634700.0 23597.0 24559.0 24912.0 29154.0 25277.0 20621.0 23798.0 21606.0 20293.0 24534.0 True False 22285.573206275338 26442.59633036864 23309.189042134774 25183.174906544828 22101.477280752883 23461.355571199652 24904.654154842392 21668.869882934163 24352.16703379463 23825.63967301267 0.9353609603824502 1.1098378340842703 0.9783237454286325 1.0569779133808457 0.9276341615200054 0.9847104167270001 1.0452879543482698 0.9094769408218037 1.0220991909559667 1.0 14.540227327816655 -6.244734183880462 24.98104948552385 0.9803550605500205 1.0235473486135103 0.09755377744756166 0.057054897754522764 1808.320428218493 2704171.6648787856 0.015833044225265665 0.020387067737317188 5.692012119517341e-07 6.244734183880462 0.04319228806348974 TCS(ph)LPDLSK ddPTM_A459_Selumetinib_30min_R1 1 TCSLPDLSK 9 0 Q96PY6-4;Q96PY6-2;Q96PY6-6;Q96PY6;Q96PY6-3 Q96PY6-4 NEK1 Serine/threonine-protein kinase Nek1 1 T(0.052)CS(0.671)LPDLS(0.277)K 113.67 0.00898 20044000.0 5409.2 7227.0 7694.7 8360.9 6834.5 6467.4 6835.5 5846.9 3738.1 5189.9 True False 5535.223835529016 6380.859480258848 6649.802003961613 6900.825768530836 6216.320681728978 6402.343827929361 6319.89273170738 5691.821218592166 6343.282679978135 5856.074218906971 0.9452106699156826 1.0896138337279864 1.1355392290780753 1.17840476581577 1.0615167174041122 1.093282562447501 1.0792029771929668 0.971951687397592 1.083197111726856 1.0 12.515718122875999 -7.613202547940102 8.419845059602087 1.0209083378547728 1.0895084317216444 0.18394752785248458 0.0619343024707272 0.4435819453318539 36.702447448507314 0.029966649910704957 0.017234535683473926 2.436674127818728e-08 7.613202547940102 0.0686000938668716 TCS(ph)PESQQIYGDIK ddPTM_A459_Selumetinib_30min_R1 1 TCSPESQQIYGDIK 14 0 Q4VC44-2;Q4VC44;Q4VC44-4;Q4VC44-3;I3L287;J3KNW1;Q4VC44-5 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 T(0.028)CS(0.97)PES(0.002)QQIYGDIK 100.4 0.0090194 5974900.0 1367.4 1171.0 1221.2 1028.5 1240.6 1208.8 1387.7 1319.4 631.31 1209.1 True False 1399.257759502769 1033.8987756168697 1055.3677475714358 848.8917823361082 1128.3879490457196 1196.6405695025844 1283.0246717563207 1284.4052259847958 1071.2869609419213 1364.2997626313456 1.0256233987785788 0.757823759803911 0.773560016997974 0.6222179359606702 0.827082126635704 0.877109710255029 0.940427248394247 0.9414391625397223 0.7852284302063601 1.0 10.413944951419841 -6.753107063641942 3.356173123638156 0.9101596476871026 0.7847302958443888 0.2082827380943424 0.10577083069107847 0.3736965765627066 8.808946654974713 0.038655646680968936 0.03620811647190457 1.765602505146646e-07 6.753107063641942 -0.12542935184271375 TCS(ph)PESQQIYGDIK ddPTM_A459_Selumetinib_30min_R2 1 TCSPESQQIYGDIK 14 0 Q4VC44-2;Q4VC44;Q4VC44-4;Q4VC44-3;I3L287;J3KNW1;Q4VC44-5 Q4VC44-2 FLYWCH1 FLYWCH-type zinc finger-containing protein 1 1 T(0.002)CS(0.994)PES(0.005)QQIYGDIK 144.08 0.00053268 6808100.0 25761.0 18874.0 19874.0 23181.0 20527.0 17533.0 19701.0 21729.0 17493.0 17776.0 True False 24329.306749453714 20321.575110524765 18595.32847717511 20023.707810544543 17948.21474629168 19948.01160127265 20617.135536790902 21792.2277925704 20992.088795257947 17262.760692405354 1.40935202560951 1.1771914975027788 1.0771932026698376 1.1599365922597682 1.0397070935582098 1.155551649977321 1.1943127697912932 1.2623837044881099 1.216033122934577 1.0 14.075375580958225 -4.769558957867492 4.3712796855375275 1.1462201129266094 1.4309836753443026 0.5258804524314893 0.07648276132184981 0.17379766261153184 7.033861886891537 0.019816406747001043 0.15559288353132367 1.6999691578022444e-05 4.769558957867492 0.2847635624176932 TCSDGGPSSELAHS(ph)PT(ph)NSGKK ddPTM_A459_Selumetinib_30min_R2 1 TCSDGGPSSELAHSPTNSGKK 21 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 2 TCSDGGPS(0.001)S(0.003)ELAHS(0.884)PT(0.556)NS(0.556)GKK 69.422 0.029859 0.0 15197.0 11696.0 12610.0 16190.0 11237.0 10238.0 12706.0 13529.0 8350.6 15111.0 True False 14352.411578411087 12593.04559143253 11798.686328729911 13984.894070692215 9825.307599945416 11648.191568689297 13296.854176461366 13568.367150153483 10020.95333525873 14674.70616690691 0.9780374077116015 0.8581463538827949 0.8040151669501402 0.9529931237894018 0.6695403293391028 0.7937597820498281 0.906107013334771 0.9246091196532205 0.6828725032912135 1.0 13.841043995948475 -4.7729615310170175 3.892716178219666 0.8370523964999834 0.992765261478398 0.1320589907073917 0.10356051332826893 0.49227784124506185 13.625978106479423 0.02515429232773927 0.22162653024875095 1.6867024236792887e-05 4.7729615310170175 0.15571286497841463 TCSDGGPSSELAHS(ph)PTNSGK ddPTM_A459_Selumetinib_30min_R1 2 TCSDGGPSSELAHSPTNSGK 20 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 TCSDGGPS(0.002)S(0.002)ELAHS(0.946)PT(0.042)NS(0.007)GK;TCSDGGPS(0.011)S(0.198)ELAHS(0.788)PT(0.003)NSGK 205.92 1.3878999999999998e-16 24739600.0 4633.0 4001.3999999999996 4049.4 4898.3 4827.0 4144.2 5046.5 4293.8 1689.06 3395.1 True False 4740.9398857513015 3532.914227799609 3499.5137217620136 4042.9038574788146 4390.398702276066 4102.513110632535 4665.838442039542 4179.914475771956 2866.2114559385423 3830.894156074503 1.2375543913772125 0.922216611544227 0.9134978882705407 1.0553420931946491 1.146050640766041 1.0709022341761483 1.2179502361455485 1.091106750924983 0.7481834107563896 1.0 11.903465450696423 -8.239312313460685 24.245623454243365 0.8740916980025426 1.076327425795514 0.3399864132121263 0.11557254940889064 556.0379959048266 609278.4490656843 0.08022294521650179 0.030260576824037346 5.763518433953841e-09 8.239312313460685 0.2022357277929714 TCSDGGPSSELAHS(ph)PTNSGK ddPTM_A459_Selumetinib_30min_R2 3 TCSDGGPSSELAHSPTNSGK 20 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 TCSDGGPSSELAHS(0.958)PT(0.029)NS(0.013)GK;TCSDGGPS(0.001)S(0.003)ELAHS(0.975)PT(0.02)NS(0.002)GK;TCSDGGPSSELAHS(0.983)PT(0.016)NS(0.001)GK 91.622 0.0010041 85900000.0 97681.0 69682.0 94984.0 109521.0 104325.0 72706.0 81333.0 77638.0 66131.0 92081.0 True False 92252.28106802481 75026.38533705553 88872.83285075979 94604.05086573685 91218.76082266656 82720.59154064511 85115.14565828213 77863.91372633721 79359.04785452488 89422.3822748301 1.0316464258858293 0.8390112567843471 0.9938544533248809 1.0579459913624472 1.020088690349531 0.9250546612190698 0.9518326787211937 0.8707430035472643 0.8874629129273626 1.0 16.448348360347275 -6.850472369138245 7.988091945335343 0.9199797969176288 0.9842612645266986 0.1818757493702422 0.06407809536828855 0.4550553238643645 35.74337469740002 0.023723108817664974 0.020941040665458887 1.4110020049510325e-07 6.850472369138245 0.06428146760906983 TCSDGGPSSELAHSPT(ph)NSGK ddPTM_A459_Selumetinib_30min_R1 1 TCSDGGPSSELAHSPTNSGK 20 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 T(0.003)CS(0.003)DGGPS(0.003)S(0.01)ELAHS(0.146)PT(0.806)NS(0.03)GK 88.264 0.008609100000000001 0.0 1157.3 1049.1 1115.8 1148.4 1194.4 830.3 1206.6 1188.1 356.46 794.66 True False 1184.262838286203 926.270884286642 964.2804886506784 947.853498137858 1086.3667308884478 821.9479358520811 1115.5851905607672 1156.5877285073036 604.8865851916765 896.6623516438883 1.3207455806692951 1.0330208272807162 1.075410924617079 1.0570907726861942 1.2115672403293911 0.9166749717384362 1.2441530398990417 1.289880997442218 0.6745979510377712 1.0 9.80842101403479 -1.5228787483712252 0.08863822835614754 0.8900102994045481 1.6662940008826064 0.11795492943071617 0.17479459265929762 454.1184921836726 2.911177651876107 3.402480269027918 42.88380606804274 0.02999999978648905 1.5228787483712252 0.7762837014780583 TCSDGGPSSELAHSPT(ph)NSGKK ddPTM_A459_Selumetinib_30min_R2 1 TCSDGGPSSELAHSPTNSGKK 21 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 TCSDGGPS(0.013)S(0.05)ELAHS(0.165)PT(0.528)NS(0.244)GKK 83.89399999999998 0.00070168 5124300.0 28111.0 30802.0 35676.0 41543.0 33398.0 20854.0 18081.0 17260.0 15920.0 36670.0 True False 26548.703157249056 33164.414355959736 33380.64500109182 35884.77173432777 29202.244658091753 23726.44920623622 18921.802326821813 17310.223742453178 19104.444841965727 35611.24181989787 0.7455146689777862 0.9312905886205023 0.9373625657289014 1.0076809990455615 0.8200288213980487 0.6662628988405287 0.5313435128861249 0.48608874214493264 0.5364723010386869 1.0 15.120045125168161 -6.736401213442404 2.82361460719757 0.5967516524905707 0.9097595413079943 0.39724429396954586 0.14918386509414167 0.22451385754665634 3.6700093786721646 0.05286893521479782 0.049822904960916035 1.8348424810986873e-07 6.736401213442404 0.3130078888174236 TCSDGGPSSELAHSPTNS(ph)GKK ddPTM_A459_Selumetinib_30min_R2 1 TCSDGGPSSELAHSPTNSGKK 21 1 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 TCSDGGPS(0.001)S(0.001)ELAHS(0.345)PT(0.087)NS(0.565)GKK 62.203 0.010766 5900500.0 20668.0 26460.0 27158.0 30748.0 30709.0 16886.0 11753.0 15062.0 11046.0 23728.0 True False 19519.355300559357 28489.396917690225 25410.683847394663 26560.069356741456 26851.060878056735 19211.893224153886 12299.537788127678 15105.827926351662 13255.508651027218 23042.910987252155 0.8470872152983576 1.236362755272161 1.1027549367114429 1.1526351584413563 1.1652634032614773 0.8337441929442998 0.533766666673844 0.655552066954932 0.5752532159830178 1.0 14.492035362023763 -6.930325100625131 3.989573044572344 0.6632936567913256 1.1100083220455983 0.6191600496950556 0.15165665047045146 0.12940789620513737 4.0964568154566665 0.05311163264943429 0.04582399732884054 1.1740183888001341e-07 6.930325100625131 0.4467146652542727 TCSKPSENEVPQQAIDSHS(ph)VK ddPTM_A459_Selumetinib_30min_R2 2 TCSKPSENEVPQQAIDSHSVK 21 1 E5RFM9;R4GMT7;O75410-7;O75410-9;O75410;O75410-2 E5RFM9 TACC1 Transforming acidic coiled-coil-containing protein 1 1 TCSKPSENEVPQQAIDS(0.155)HS(0.845)VK;TCSKPSENEVPQQAIDS(0.058)HS(0.942)VK 96.181 0.00021728 10895600.0 57962.0 47929.0 48402.0 54107.0 48640.0 48001.0 46710.0 46152.0 36918.0 48569.0 True False 54740.704080270014 51605.00018397484 45287.868016112974 46737.53326021888 42529.40835288285 54612.7020403062 48882.10755410908 46286.29467912511 44302.6315751062 47166.68677258304 1.16057980379681 1.0940984774442901 0.9601664037686408 0.9909013428389968 0.9016831849551125 1.1578659807847975 1.036369329688071 0.9813344512048771 0.9392780075631335 1.0 15.525480641755845 -5.047329291143327 3.7521949157357666 0.9992686586106404 1.1521919679463102 0.4127241811369121 0.06471613320583913 0.22387983801517566 6.355427773726393 0.01745040449376147 0.06384534474922468 8.967486031525755e-06 5.047329291143327 0.15292330933566978 TDAEAT(ph)DTEATET ddPTM_A459_Selumetinib_30min_R1 2 TDAEATDTEATET 13 0 Q9Y3D3 Q9Y3D3 MRPS16 28S ribosomal protein S16, mitochondrial 1 TDAEAT(0.84)DT(0.16)EATET;T(0.001)DAEAT(0.992)DT(0.007)EATET 155.48 0.00085486 8553600.0 3968.3999999999996 4815.5 4250.7 4724.4 3415.7 4248.2 3186.3 3513.1 2307.6 2588.7 True False 4060.855998837784 4251.699021334784 3673.4782874237635 3899.372227971521 3106.7505380908156 4205.466965056983 2945.9548256951543 3419.92117584295 3915.82865956436 2920.9848610733284 1.3902352090060492 1.4555703721697755 1.257616339056933 1.3349511940088181 1.0635969324911965 1.4397428145216975 1.0085484745075504 1.1708109896147443 1.3405850580565735 1.0 11.512239165625813 -1.5228787452803376 0.13825890855300796 1.0065456048142092 2.4663022368663405 0.37076406231941683 0.1315629489175111 82.29506189582838 0.762852234108913 0.570878221870348 23.671745186665873 0.029999999999999995 1.5228787452803376 1.4597566320521314 TDALTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 TDALTSSPGR 10 0 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 TDALT(0.008)S(0.084)S(0.908)PGR 121.61 0.0047238 14237000.0 5167.2 7367.7 3913.9 3817.9 4454.4 4740.8 6139.9 5630.7 3060.7 6358.8 True False 5287.585706379047 6505.086258849198 3382.4138775137912 3151.1754358590447 4051.500306488192 4693.111856301997 5676.762399738151 5481.35554490874 5193.784355316624 7175.013919957152 0.7369443133304225 0.9066304722776127 0.47141565371820077 0.43918736200554476 0.5646679367713877 0.654090975802598 0.7911848622270061 0.763950510209111 0.7238709796604326 1.0 12.808765915367998 -8.63271326048585 0.6505053698080852 0.9949387006012734 0.6298216420862468 0.3881248869888274 0.13262380803818283 1.0888981719150375 1.0271705169370786 0.154003041307042 0.061511537849405926 2.329628869139871e-09 8.63271326048585 -0.3651170585150266 TDALTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 TDALTSSPGR 10 0 P49736;F8WDM3;C9J013;C9JZ21 P49736 MCM2 DNA replication licensing factor MCM2 1 TDALTS(0.003)S(0.997)PGR;TDALT(0.003)S(0.027)S(0.97)PGR 136.49 0.0018501 106079000.0 873970.0 507910.0 802200.0 823800.0 936960.0 762450.0 1068320.0 1122240.0 954170.0 672880.0 True False 825398.2461791101 546865.063811944 750587.3253693208 711597.0188657338 819250.7082713225 867470.5666680174 1117998.9968359198 1125505.532603167 1145030.6617373398 653452.2060478021 1.263134837620748 0.8368860931995064 1.148649156621583 1.0889809725635515 1.2537270525510962 1.32751953186391 1.7109116573311172 1.7223991627642201 1.752279127899336 1.0 19.317722194590097 -6.827083993036474 1.7607709534041045 1.6025499771120246 1.0756184236884099 0.4271427406333691 0.23043061305468462 0.2841021024043033 1.8167793904540654 0.0947696099955542 0.0823527226388964 1.4890730614720111e-07 6.827083993036474 -0.5269315534236148 TDANESSS(ph)SPEIR ddPTM_A459_Selumetinib_30min_R1 1 TDANESSSSPEIR 13 0 Q96JM7-2;Q96JM7 Q96JM7-2 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 1 TDANES(0.057)S(0.057)S(0.443)S(0.443)PEIR 98.337 0.012638 6429300.0 2012.7 2215.0 2122.6 2249.2 2076.8 1920.0 2615.1 1909.4 1082.8 1856.7 True False 2059.5919939675455 1955.6667702744378 1834.3625786072148 1856.4194427130535 1888.9538066888217 1900.6865432205175 2417.840901570912 1858.7565093947032 1837.4325154170103 2095.0255307895286 0.9830868233817515 0.9334811158780617 0.8755800593589518 0.8861082671452913 0.9016376072404965 0.9072378905588931 1.1540866046915084 0.8872237985062715 0.8770454051338257 1.0 11.032752109932304 TDANESSSS(ph)PEIR ddPTM_A459_Selumetinib_30min_R1 1 TDANESSSSPEIR 13 0 Q96JM7-2;Q96JM7 Q96JM7-2 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 1 TDANES(0.003)S(0.008)S(0.227)S(0.762)PEIR 146.84 0.00058932 4561000.0 2289.3 2323.3 2399.4 2588.3 2443.3 1606.3 2146.5 2267.5 1308.8 1753.5 True False 2342.6362357976386 2051.286955927134 2073.574658960779 2136.3019934084105 2222.303946399652 1590.1420804037086 1984.5877768429343 2207.358534121968 2220.9380090300897 1978.5788055364012 1.1839994592292926 1.036747664630432 1.0480121656810246 1.079715393407972 1.1231819223885682 0.8036789214330102 1.0030370138857845 1.1156283125773925 1.1224915595049973 1.0 10.95024881274368 -4.76143531718633 12.1907177028878 1.0365740135298467 1.1841814828844779 0.1960112393827801 0.08934587822991152 0.10792787651388354 938.9520241625285 0.02342705190768486 0.1310735366605021 1.73206698158256e-05 4.76143531718633 0.1476074693546312 TDANESSSS(ph)PEIR ddPTM_A459_Selumetinib_30min_R2 2 TDANESSSSPEIR 13 0 Q96JM7-2;Q96JM7 Q96JM7-2 L3MBTL3 Lethal(3)malignant brain tumor-like protein 3 1 TDANES(0.001)S(0.001)S(0.035)S(0.963)PEIR;TDANESSS(0.003)S(0.997)PEIR 161.21 0.00036373 12881300.0 96567.0 90184.0 99486.0 112988.0 112219.0 79508.0 84144.0 85626.0 78044.0 92937.0 True False 91200.19272832961 97100.82281273537 93085.17907216678 97598.83948482834 98121.04596941128 90459.50529823673 88056.8627281729 85875.15748385264 93654.98073155602 90253.66733067497 1.010487389882859 1.0758656759838192 1.0313728164764497 1.0813836420324265 1.0871696283532888 1.0022806604279868 0.9756596638399929 0.9514866267895777 1.0376861517263247 1.0 16.461697934621654 -6.894322441166192 5.889782135639161 0.987458080242675 1.0579409336644674 0.5360794271995389 0.029706676184678375 0.15525487599797072 7.570273822891765 0.01041392246537095 0.009177512690313448 1.275491470804657e-07 6.894322441166192 0.07048285342179239 TDASS(ph)ASSFLDSDELER ddPTM_A459_Selumetinib_30min_R1 1 TDASSASSFLDSDELER 17 0 G3XAC6;Q14498-2;Q14498;H0Y4X3;Q14498-3;A0A0U1RQH7;A0A0U1RQW2 G3XAC6 RBM39 RNA-binding protein 39 1 TDAS(0.055)S(0.834)AS(0.055)S(0.055)FLDSDELER 311.81 3.2700999999999996e-103 5245400.0 907.57 852.4 957.42 1208.6 697.4 688.75 866.86 903.85 530.89 693.22 True False 928.7146151761943 752.6006117299912 827.4076227316116 997.5406982318141 634.3202931359705 681.8218003349645 801.4720522870099 879.8769618814296 900.8815553285341 782.2015395346136 1.1873086004519393 0.9621569041883578 1.0577933958349075 1.275298817265587 0.81094227136573 0.8716702357050178 1.0246362500946515 1.1248724496309863 1.1517256228676456 1.0 9.611396565370981 -4.744557045868225 24.51478947815546 1.0313281717179748 1.18730918490883 0.11863069903523316 0.1278044114912866 1995.6589405341692 2897691.2608569986 0.033705558086455575 0.9211271443731055 1.800706590755687e-05 4.744557045868225 0.15598101319085522 TDASSAS(ph)SFLDSDELER ddPTM_A459_Selumetinib_30min_R1 1 TDASSASSFLDSDELER 17 0 G3XAC6;Q14498-2;Q14498;H0Y4X3;Q14498-3;A0A0U1RQH7;A0A0U1RQW2 G3XAC6 RBM39 RNA-binding protein 39 1 TDASSAS(0.651)S(0.349)FLDSDELER 287.88 1.2831999999999992e-75 6294100.0 1765.6 2017.5 2198.1 2537.7 2124.3 1666.8 2181.2 2116.6 1188.1 1601.2 True False 1806.7350447404488 1781.290162089696 1899.6100932990269 2094.538333528772 1932.1574400756267 1650.0335053333122 2016.6703279058054 2060.460892314249 2016.118924609299 1806.7296170087745 1.0000030041748489 0.9859196115015836 1.0514080664953207 1.1592981671471652 1.0694225754014652 0.9132708568009812 1.1161992967407095 1.1404367720088369 1.1158941025980356 1.0 10.819164902991044 TDASSASS(ph)FLDSDELER ddPTM_A459_Selumetinib_30min_R1 1 TDASSASSFLDSDELER 17 0 G3XAC6;Q14498-2;Q14498;H0Y4X3;Q14498-3;A0A0U1RQH7;A0A0U1RQW2 G3XAC6 RBM39 RNA-binding protein 39 1 TDASSAS(0.024)S(0.976)FLDSDELER 265.43 5.828899999999999e-41 7020900.0 1520.2 1826.7 1978.6 2060.5 1742.0 1236.9 1666.4 1799.6 1033.7 1340.4 True False 1555.6177022057257 1612.8291147902085 1709.9169876718327 1700.6723553753545 1584.4364075750796 1224.457909015343 1540.7021063736634 1751.8687620753674 1754.1134015391228 1512.4533966016504 1.0285392632269277 1.066366156083945 1.1305584631657846 1.1244461212468533 1.0475935398308263 0.8095838931411652 1.0186774083984904 1.1582960281696364 1.1597801330477098 1.0 10.562674973807978 -12.085612100697322 2.1772794384567318 0.01831212595118232 1.0584424824965055 0.03329572576224393 0.097151322296083 5641875.2899538595 1243227.6493808953 26568809.66106753 0.02748886278670722 8.210845859807501e-13 12.085612100697322 1.0401303565453233 TDASSASSFLDSDELER ddPTM_A459_Selumetinib_30min_R1 2 TDASSASSFLDSDELER 17 0 G3XAC6;Q14498-2;Q14498;H0Y4X3;Q14498-3;A0A0U1RQH7;A0A0U1RQW2 G3XAC6 RBM39 RNA-binding protein 39 0 ; 211.06 6.541399999999998e-29 2118200.0 1009.4100000000001 1008.13 870.38 788.37 1310.3600000000001 881.09 1215.51 1081.15 341.85 570.5699999999999 False True 1032.9272890300501 890.0976709330786 752.187176655115 650.6959790377417 1191.8381693628476 872.2270345657118 1123.823102087285 1052.4743899298635 580.0944822638573 643.8082173224437 1.6044021515070546 1.3825509631345443 1.168340441169596 1.0106984681617512 1.8512316825026318 1.3547932615604799 1.7455867630288904 1.63476383434035 0.9010361574389845 1.0 9.33048718071688 -8.270284350608582 24.90520561579516 0.950517975465943 1.459010142923188 0.4191374024636223 0.24394025278296158 707.942155203485 1993361.164673117 0.2339493318904293 0.0640564614302931 5.366802944651095e-09 8.270284350608582 0.5084921674572451 TDATDGKDYNAS(ph)ASTISPPSSMEEDKFSR ddPTM_A459_Selumetinib_30min_R2 1 TDATDGKDYNASASTISPPSSMEEDKFSR 29 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.009)DAT(0.008)DGKDY(0.143)NAS(0.252)AS(0.252)T(0.252)IS(0.084)PPS(0.001)SMEEDKFSR 41.908 0.028432 56236000.0 49909.0 61009.0 50966.0 47622.0 56656.0 43430.0 38618.0 36288.0 24688.0 55141.0 True False 47135.25758155681 65688.19412514592 47686.903047585096 41135.801447467835 49538.36676893364 49412.08828171284 40413.81352011528 36393.59207219818 29626.289840354875 53548.936056476356 0.8802277141761464 1.226694664033412 0.8905294214863809 0.7681908265008891 0.9251045943599534 0.9227464058221341 0.7547080576445463 0.6796324026646396 0.5532563673927895 1.0 15.708570290448531 -6.064361039779398 0.6433437458096888 0.7360329758935797 1.0617496985276298 0.2616214531480948 0.15122549705761698 1.2429874884569492 1.0105077760151482 0.0970068745112949 0.24026243561211333 8.622614304062726e-07 6.064361039779398 0.32571672263405005 TDATDGKDYNASAS(ph)TISPPSSMEEDKFSR ddPTM_A459_Selumetinib_30min_R1 2 TDATDGKDYNASASTISPPSSMEEDKFSR 29 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TDATDGKDY(0.001)NAS(0.053)AS(0.624)T(0.074)IS(0.239)PPS(0.006)S(0.003)MEEDKFSR;TDATDGKDYNAS(0.024)AS(0.96)T(0.008)IS(0.008)PPSSMEEDKFSR 192.16 3.5266999999999998e-34 235778000.0 5921.4 5880.4 6455.599999999999 7268.1 6135.3 6285.900000000001 5947.4 5545.5 3135.9500000000003 4552.5 True False 6059.357098961307 5191.920034276209 5578.9649780725185 5998.862774134243 5580.36319827519 6222.669553140551 5498.782829720788 5398.415325677346 5321.478109274079 5136.857720105203 1.1795843741681853 1.0107190654620424 1.0860657004839647 1.1678078508297456 1.086337894163225 1.2113766610248085 1.0704565182327404 1.050917821715877 1.0359403353622756 1.0 12.32667039935507 -7.597912980286733 3.7093151783742595 1.0327804825293687 1.1185775133599367 0.37057733872529486 0.05499880115264305 0.2829417138436752 7.722244343251015 0.02830930005793311 0.015528000726564765 2.5239864537263465e-08 7.597912980286733 0.085797030830568 TDATDGKDYNASAST(ph)ISPPSSMEEDK ddPTM_A459_Selumetinib_30min_R1 1 TDATDGKDYNASASTISPPSSMEEDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TDATDGKDYNAS(0.01)AS(0.167)T(0.469)IS(0.32)PPS(0.015)S(0.019)MEEDK 91.416 4.5358e-05 10166000.0 1310.5 1829.1 1165.6 940.84 964.81 1147.3 1448.9 1195.8 713.33 1539.1 True False 1341.0321002108954 1614.9481216744798 1007.3179221824976 776.539955754112 877.5431058510402 1135.7592036650524 1339.6083064839177 1164.0834994941786 1210.4689104381373 1736.6584771035505 0.7721910311620438 0.9299169312598164 0.5800322489788158 0.44714603705459 0.5053055148267448 0.6539911091553848 0.7713711844588784 0.6703007613999449 0.6970103370335614 1.0 10.762098353141479 -9.461090267287366 0.7743295003280279 1.008351691048413 0.6563129847327487 0.3656755432787626 0.13143367263895178 5.894105048606403 3.849552545738489 0.29212703265670376 0.05145956775095431 3.4586748245208905e-10 9.461090267287366 -0.35203870631566425 TDATDGKDYNASAST(ph)ISPPSSMEEDK ddPTM_A459_Selumetinib_30min_R2 1 TDATDGKDYNASASTISPPSSMEEDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TDATDGKDYNASAS(0.046)T(0.926)IS(0.028)PPSSMEEDK 132.36 7.5341e-09 8244000.0 21081.0 13294.0 13245.0 15465.0 15706.0 14368.0 16297.0 13822.0 10902.0 14719.0 True False 19909.402413929332 14313.607053052681 12392.831120065634 13358.640321386973 13732.871866578507 16347.061580282056 17054.842791892876 13862.219731644722 13082.704627331055 14294.024225445231 1.39284795519571 1.0013700010087145 0.8669938517387409 0.934561192194347 0.9607421709928405 1.1436290664165902 1.1931449480499008 0.969791257731896 0.9152569228224848 1.0 13.803124518010268 -4.761457095879646 12.079838367457983 1.0007593649467352 1.3933623538585793 0.6098139048634286 0.09464197151023632 0.04606385864382396 375.6162347947598 0.02650229100117851 0.14823163181246457 1.7319801252872368e-05 4.761457095879646 0.3926029889118441 TDATDGKDYNASASTIS(ph)PPSSMEEDK ddPTM_A459_Selumetinib_30min_R2 1 TDATDGKDYNASASTISPPSSMEEDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TDATDGKDYNASAS(0.003)T(0.038)IS(0.936)PPS(0.017)S(0.006)MEEDK 126.8 3.8861000000000005e-09 9427800.0 49416.0 37898.0 41269.0 44165.0 38023.0 34398.0 50324.0 48701.0 32122.0 41144.0 True False 46669.65654792145 40804.6547387235 38613.797470289785 38149.65081112548 33246.21081006714 39136.01226604553 52664.165715114235 48842.71184711545 38547.29756366978 39956.06581504986 1.168024318609037 1.0212380500022604 0.966406393688177 0.9547899682544828 0.8320691772798267 0.979476118775051 1.3180518312010023 1.222410436332757 0.9647420680028651 1.0 15.28612691792159 -7.100402081116367 24.99998533442783 1.14539867462712 0.9790678281434205 0.2304804584079887 0.12221240997119918 54.243896317300965 13496.741480396186 0.04808953359666002 0.03725000230077969 7.93593165329855e-08 7.100402081116367 -0.16633084648369956 TDATDGKDYNASASTIS(ph)PPSSMEEDKFSR ddPTM_A459_Selumetinib_30min_R2 3 TDATDGKDYNASASTISPPSSMEEDKFSR 29 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TDATDGKDY(0.006)NAS(0.014)AS(0.063)T(0.083)IS(0.833)PPS(0.001)SMEEDKFSR;T(0.003)DAT(0.016)DGKDY(0.091)NAS(0.123)AS(0.123)T(0.086)IS(0.555)PPS(0.002)S(0.001)MEEDKFSR;TDATDGKDYNASAST(0.001)IS(0.997)PPS(0.001)SMEEDKFSR 84.646 5.4407e-06 83816600.0 146204.0 146481.0 153202.0 171273.0 161743.0 110324.0 104220.0 111432.0 81770.3 158675.0 True False 138078.56698098406 157715.62168934962 143345.15011372566 147945.32193759512 141423.39833923368 125520.12957844097 109066.4365080122 111756.24867143927 98126.64485307712 154093.64046283838 0.8960692119820705 1.0235050662417489 0.9302470217665806 0.9601001150548715 0.9177756973905729 0.8145704728723814 0.7077932365048831 0.7252489352303328 0.6367987968766406 1.0 17.233447796626635 -6.825220552883606 2.43359623946532 0.7448996304173306 0.9549238701511207 0.44784962815123197 0.0937327784460404 0.22740764755192713 2.754004803614791 0.034464762520507626 0.03063840956092107 1.4954759980219185e-07 6.825220552883606 0.21002423973379003 TDATDGKDYNASASTISPPSS(ph)MEEDKFSR ddPTM_A459_Selumetinib_30min_R1 1 TDATDGKDYNASASTISPPSSMEEDKFSR 29 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TDATDGKDYNAS(0.002)AS(0.004)T(0.009)IS(0.009)PPS(0.121)S(0.845)MEEDKFS(0.009)R 53.777 0.037744 32906000.0 1950.5 1960.0 2472.1 2791.6 2071.7 2350.9 1925.1 2405.7 1445.2 1974.4 True False 1995.9428549876793 1730.522288820721 2136.4023982732942 2304.0994648220517 1884.3151007883423 2327.2520804464157 1779.8881570930973 2341.893021185104 2452.398846768251 2227.8334722846157 0.8959120507965367 0.7767736279884923 0.9589596461545395 1.0342332555310905 0.8458060821107964 1.0446256910126444 0.7989323166366847 1.051197520065771 1.1007998924862847 1.0 11.121425681752925 -2.9293666164231738 0.21588666509165086 1.037781488097696 0.4291292671578566 0.2333374247573029 0.09520094436512425 42.45265103565216 0.9058932376309167 0.16194836210441713 7.899318055882707 0.0011766122986446327 2.9293666164231738 -0.6086522209398395 TDAY(ph)VRAMT(ph)EKR ddPTM_A459_Selumetinib_30min_R1 1 TDAYVRAMTEKR 12 2 Q16518 Q16518 RPE65 Retinoid isomerohydrolase 2 T(0.035)DAY(0.965)VRAMT(1)EKR 100.22 0.006220799999999999 4196900.0 1806.4 1430.8 2152.8 2112.6 1443.7 1330.8 1283.5 910.91 933.03 1015.1 True False 1848.4856053574692 1263.2812708391261 1860.4615844839398 1743.6740684134777 1313.1175899059363 1317.4133602697218 1186.6845616482212 886.7497077473179 1583.2837641850135 1145.3979729113214 1.6138369798744021 1.1029190732965715 1.6242927161422345 1.5223303250498033 1.1464291198004417 1.1501795807453539 1.0360456275576946 0.7741848062585768 1.3823001276671492 1.0 10.161633240004475 -6.4038553557283855 3.5178371786107463 1.0581342982983695 1.450523188676022 0.48155146828894213 0.1957332979567681 0.22215257987147322 5.0303873244086015 0.06261233501658425 0.0711490994395306 3.9458870022558185e-07 6.4038553557283855 0.39238889037765246 TDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPS(ph)PEAR ddPTM_A459_Selumetinib_30min_R1 2 TDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEAR 42 0 Q15424-2;Q15424;Q15424-4;Q15424-3;Q14151 Q15424-2;Q14151 SAFB;SAFB2 Scaffold attachment factor B1;Scaffold attachment factor B2 1 TDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPS(1)PEAR;TDCEPVGLEPAVEQSSAASELAEASSEELAEAPT(0.006)EAPS(0.994)PEAR 133.36 1.0192e-36 32947000.0 10570.599999999999 12978.7 10894.4 11085.599999999999 12340.9 10973.2 12468.8 11299.3 6818.3 9621.900000000001 True False 10816.874413192894 11459.147770366058 9415.00031865563 9149.708062484362 11224.667773962863 10862.81957086843 11528.26837731153 10999.60585870093 11570.157111071114 10856.964590242782 0.9963074230631721 1.0554651509745607 0.8671853205744952 0.8427501062964927 1.0338679545893092 1.000539283385976 1.0618316272001156 1.0131382272892684 1.0656898633960068 1.0 13.406333187782426 -6.393529957782263 21.243371984198017 1.0300496486546562 0.9427592876609238 0.34625871331683 0.059698598516959696 6.390644367855972 1039.7090686894494 0.02010526257217802 0.02279719450929611 4.040824998027183e-07 6.393529957782263 -0.08729036099373244 TDCSSGDASRPSSDNADS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 TDCSSGDASRPSSDNADSPK 20 1 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 TDCSSGDASRPSSDNADS(1)PK;TDCSSGDASRPSSDNADS(1)PK 99.097 0.00046122 63501000.0 4103.5 4937.0 6280.0 5806.4 3331.1 4329.3 3986.8999999999996 3697.7 3119.1000000000004 4056.0 True False 4199.1035659789495 4358.973744850968 5427.210493570765 4792.421239627008 3029.802593153473 4285.751172689892 3686.164923128393 3599.624984177644 5292.884889949388 4576.6271087856585 0.9175105303899492 0.9524424081837767 1.1858537662271542 1.0471513465510645 0.6620164853145283 0.9364431645441732 0.8054326549899896 0.7865235464054995 1.156503417066412 1.0 12.16006903449421 TDDEVVQREEEAIQLDGLNASQIR ddPTM_A459_Selumetinib_30min_R1 1 TDDEVVQREEEAIQLDGLNASQIR 24 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 181.64 5.675399999999999e-20 5390800.0 419.93 502.68 879.41 680.84 825.67 694.03 550.95 408.21 420.51 405.09 False True 429.7135519584599 443.825991910408 759.9909522533545 561.9440749496508 750.9882942838782 687.0486883288212 509.3913979276104 397.3829447470467 713.5747571647645 457.0872474107451 0.9401127561371521 0.9709874743269301 1.662682467206126 1.2294022161696405 1.6429867569878394 1.5031018524816324 1.1144292491491543 0.8693809486002849 1.561134687539283 1.0 8.836325758544008 -11.46578823423027 2.511530615272924 0.7997085837658421 1.2786948873974862 0.07802284423598616 0.28575485027744446 17330715.15769889 7860150.771445982 20275476.661191724 0.07565724874150459 3.4214623532817712e-12 11.46578823423027 0.4789863036316441 TDDT(ph)SGEDNDEKEAVASK ddPTM_A459_Selumetinib_30min_R1 1 TDDTSGEDNDEKEAVASK 18 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 T(0.052)DDT(0.884)S(0.064)GEDNDEKEAVASK 79.143 0.017089 7406600.0 2036.1 1567.7 1979.5 2283.4 1895.7 1497.2 1797.5 1793.1 981.18 1778.0 True False 2083.5371684390716 1384.1529551960427 1710.6947726151802 1884.647054726562 1724.234269713019 1482.139527348833 1661.913127824448 1745.5411631903423 1664.9907974481537 2006.2236191866104 1.0385368552703047 0.689929548211193 0.8526939650470033 0.9394002925210602 0.8594427127779908 0.7387708494578195 0.8283788067943506 0.870063110860016 0.8299128679001377 1.0 10.970266706320638 -11.338557499303572 2.3268370421289672 1.0578063714987065 0.8447078289959192 0.1948272629139851 0.09117270952440511 17285914.845381293 10213446.416215776 5606881.983505711 0.02270419535084617 4.586089233149248e-12 11.338557499303572 -0.21309854250278726 TDDYLDQPCYETINR ddPTM_A459_Selumetinib_30min_R1 2 TDDYLDQPCYETINR 15 0 P50395-2;P50395;Q5SX87;Q5SX91 P50395-2 GDI2 Rab GDP dissociation inhibitor beta 0 ; 225.23 4.1946e-09 10973000.0 1997.08 2335.4 1815.79 2307.3999999999996 1843.33 1628.6999999999998 1930.5900000000001 1460.29 978.3299999999999 1544.78 False True 2043.6080783587756 2061.9702823019948 1569.2156914205189 1904.45590526236 1676.6011269663434 1612.3167567412802 1784.964041973075 1421.5583655095782 1660.1545556039175 1743.0675604314358 1.1724204642147957 1.1829548831667922 0.9002609692490141 1.0925886916230476 0.9618681254967301 0.9249881033539555 1.0240360629115655 0.8155497800427889 0.9524327073088342 1.0 10.767412773351412 -4.303102402652322 0.5795945070363748 0.9339524740782051 1.5550217662494628 0.5097096046302958 0.07847056969528053 4.797022602524324 0.8175004177265804 0.03840815719973506 2.253523402532354 4.976197369785004e-05 4.303102402652322 0.6210692921712576 TDDYLDQPCYETINR ddPTM_A459_Selumetinib_30min_R2 1 TDDYLDQPCYETINR 15 0 P50395-2;P50395;Q5SX87;Q5SX91 P50395-2 GDI2 Rab GDP dissociation inhibitor beta 0 191.48 0.00039796 3869900.0 11481.0 10726.0 10725.0 13975.0 12124.0 8703.3 9166.2 7924.8 7990.5 10812.0 False True 10842.931982084476 11548.649710474128 10034.965176497084 12071.580891780332 10600.874730064796 9902.1005743088 9592.446462480722 7947.859855978738 9588.823273224065 10499.829467050326 1.0326769607173951 1.0998892645556884 0.955726491367118 1.1496930430786845 1.0096235146800776 0.9430725142139434 0.9135811674449499 0.756951327725849 0.913236096197076 1.0 13.358078276103827 -6.884688844474493 2.037803263087252 0.87633300724117 1.0565856546176646 0.498061802466524 0.073534458916331 0.2426639235242472 2.0595221755038153 0.02984971749204781 0.025193965280907685 1.304100782575298e-07 6.884688844474493 0.1802526473764946 TDEERPPVEHS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 TDEERPPVEHSPEK 14 1 Q15170-2 Q15170-2 1 TDEERPPVEHS(1)PEK 110.32 0.0023584 48921000.0 3243.8 3904.3 2930.8 2767.7 2972.2 3246.8 4420.9 3936.8 2466.0 4630.7 True False 3319.3742286639467 3447.1827409401717 2532.813457732036 2284.373151163488 2703.365034784531 3214.1401398585294 4087.42795371299 3832.383275471384 4184.621890486098 5225.095451837707 0.63527532831893 0.6597358407544059 0.48474013175036373 0.4371926163301105 0.5173809856112268 0.6151352007795554 0.7822685712421598 0.7334570843339341 0.8008699418140455 1.0 12.351241677192464 -7.999549869905815 0.7140765006266245 0.976341821491432 0.5423014819208706 0.7753992420073941 0.07622275004637706 0.3417761309058526 0.3594514859902587 0.08254812879215587 0.03689901314536093 1.0010370001580119e-08 7.999549869905815 -0.43404033957056143 TDEHSSAGRY(ph)VRRR ddPTM_A459_Selumetinib_30min_R1 1 TDEHSSAGRYVRRR 14 3 A0A087WX74 A0A087WX74 CLK4 1 T(0.044)DEHS(0.044)S(0.044)AGRY(0.867)VRRR 78.939 0.043232 11873000.0 765.4 997.98 1030.9 1085.7 756.58 676.93 634.46 861.82 398.2 591.15 True False 783.2323307908579 881.1360376516848 890.90944232836 896.1028761130895 688.1474725850483 670.1206988032633 586.6021713933234 838.9617340141106 675.7163166226942 667.0298607886195 1.1742087975864437 1.320984395825894 1.3356365204925773 1.3434224294751067 1.0316591700579367 1.004633732605298 0.8794241545645233 1.2577573858870703 1.013022589159359 1.0 9.381607537462497 -6.267028274210242 24.679322374858273 1.0350653053434593 1.2985269574477267 0.6328374837832065 0.09788827373236499 257.4219120839091 1136716.3618867956 0.03067163993590116 0.035773403217453925 5.407191189437683e-07 6.267028274210242 0.2634616521042674 TDENIDTPGT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 TDENIDTPGTPK 12 0 Q6ULP2-7;Q6ULP2-8;Q6ULP2-6;Q6ULP2;Q6ULP2-9;B8ZZI9;A0A0U1RR74 Q6ULP2-7 AFTPH Aftiphilin 1 TDENIDT(0.004)PGT(0.996)PK;TDENIDT(0.003)PGT(0.997)PK 108.36 0.01893 6896600.0 3867.4 4197.0 4756.4 4480.6 3340.3999999999996 3728.5 4038.7 3923.6 2954.8 4018.0 True False 3957.5028953495735 3705.613288867636 4110.507005035027 3698.147321278723 3038.2614097955193 3690.994675207135 3734.0576074239734 3819.5333823510277 5014.079789946602 4533.749438634309 0.8728984583104097 0.8173396741536448 0.9066462672170136 0.8156929206905417 0.6701432116881008 0.8141152759246804 0.8236135803192457 0.8424668001727015 1.1059455000356135 1.0 12.14648894622416 -8.19914686491204 5.818435315064935 1.0521607407860023 0.816677354382335 0.6905474546513284 0.062324396960000805 0.11440333883092169 7.8030150095486155 0.046813941462018935 0.0168431728663383 6.321980254766311e-09 8.19914686491204 -0.23548338640366728 TDEQALLS(ph)SILAK ddPTM_A459_Selumetinib_30min_R2 1 TDEQALLSSILAK 13 0 F5GX19;F5H3Y3;Q6IAA8;H0YFI1;F5H479 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 TDEQALLS(0.5)S(0.5)ILAK 96.707 0.013964 2359500.0 18468.0 4847.2 13585.0 17505.0 12963.0 9875.5 14555.0 14080.0 9651.9 8583.3 True False 17441.622493261555 5218.964653795466 12710.955890229643 15120.788802190684 11334.47204930963 11235.760484136663 15231.836340185357 14120.970468930524 11582.54969661866 8335.477826908356 2.0924562281189205 0.6261146345981211 1.524922284502574 1.8140278357382436 1.359786719451164 1.347944379129136 1.8273501119533146 1.6940805029011776 1.389548378285909 1.0 13.025049187983216 -4.491893730627988 24.59150682778922 1.4422942785859223 5.8507371187269355 0.25180595660674987 0.351701932524266 557.1020189193121 608187.4796175631 0.08428070053814407 44520.90271844132 3.221857064804931e-05 4.491893730627988 4.408442840141014 TDEQALLSS(ph)ILAK ddPTM_A459_Selumetinib_30min_R1 1 TDEQALLSSILAK 13 0 F5GX19;F5H3Y3;Q6IAA8;H0YFI1;F5H479 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 TDEQALLS(0.049)S(0.951)ILAK 179.5 0.00010967 8360600.0 3326.4 2721.8 3223.7 2097.7 2649.6 2961.0 2926.2 4276.5 2106.0 2699.3 True False 3403.8986479523282 2403.1303906695093 2785.939246516573 1731.3760737058387 2409.9441478248737 2931.2150283728924 2705.4743781028624 4163.073327970273 3573.728183845791 3045.78144840856 1.1175781012557175 0.7890028983941576 0.914687837491506 0.5684505283891901 0.7912400113554059 0.9623852131296127 0.88826937320683 1.3668325841781932 1.1733370382543653 1.0 11.572596708887406 -7.664779181753573 6.868828032894756 1.2008440192217165 0.8480083768298871 0.4637470479510324 0.15630840095102488 0.17627133188703126 10.644909068956933 0.07510432897462209 0.04285528994190882 2.1638184436263728e-08 7.664779181753573 -0.3528356423918294 TDEQALLSS(ph)ILAK ddPTM_A459_Selumetinib_30min_R2 1 TDEQALLSSILAK 13 0 F5GX19;F5H3Y3;Q6IAA8;H0YFI1;F5H479 F5GX19 LAMTOR1 Ragulator complex protein LAMTOR1 1 TDEQALLS(0.014)S(0.986)ILAK 186.85 0.00013637 1576100.0 17087.0 4290.3 12599.0 16629.0 10589.0 12224.0 10464.0 14537.0 9943.5 9077.6 True False 16137.372944680556 4619.352214511203 11788.394056754014 14364.101513374975 9258.71515313891 13907.745041576269 10950.596734022643 14579.30026327009 11932.4778446034 8815.506101562713 1.83056681701121 0.5240030647465989 1.337233951283217 1.6294131440540516 1.0502760756410379 1.5776456713144198 1.2421971702885495 1.6538245331922166 1.3535783093029845 1.0 13.105827682256916 -5.495992497623446 24.769752440294468 1.3850537624947623 1.1156183939081419 0.028532775955494305 0.36220740370671334 1544.8088827089762 1423198.2695364666 0.08735378260092398 0.18094892453321354 3.1915929889479337e-06 5.495992497623446 -0.2694353685866204 TDES(ph)SPVLSPR ddPTM_A459_Selumetinib_30min_R1 2 TDESSPVLSPR 11 0 Q8NA72-3;Q8NA72 Q8NA72-3 POC5 Centrosomal protein POC5 1 TDES(0.5)S(0.5)PVLSPR;TDES(0.78)S(0.22)PVLSPR 190.36 1.98e-05 23888000.0 4111.5 4589.7 4759.2 4868.2 4831.2 3988.7999999999997 3971.3 3522.1000000000004 2155.7 3509.4 True False 4207.289950413655 4052.3357903063597 4112.9267804143265 4018.0602574318373 4394.218813017637 3948.6762935406246 3671.741643688027 3428.682466606829 3658.0654539014126 3959.8656744507825 1.0624829972287353 1.0233518314654455 1.0386531055715098 1.014696100263332 1.1096888567128222 0.9971743029107395 0.9272389382746633 0.8658582761351807 0.9237852378436477 1.0 11.95123577706532 -7.135295346136055 3.413614708275049 0.9176032883723603 1.0462211430219075 0.6651802965158848 0.03973614171825954 0.138939476203905 2.9887544325628808 0.015740270489414145 0.011875275204835842 7.323263381929173e-08 7.135295346136055 0.12861785464954723 TDES(ph)SPVLSPR ddPTM_A459_Selumetinib_30min_R2 1 TDESSPVLSPR 11 0 Q8NA72-3;Q8NA72 Q8NA72-3 POC5 Centrosomal protein POC5 1 TDES(0.635)S(0.365)PVLSPR 153.54 0.00055889 10158000.0 38850.0 30684.0 38106.0 50979.0 40924.0 28877.0 31782.0 33372.0 26445.0 28940.0 True False 36690.87252887218 33037.36413538953 35654.30144667581 44035.57225631983 35782.76125479806 32854.54463069358 33259.92597483826 33469.10699496799 31734.738935036647 28104.427004849847 1.3055193234340132 1.1755217115683743 1.268636483516391 1.5668553658368776 1.2732072868314732 1.1690167042019404 1.183440814114401 1.1908838059282398 1.129172244983338 1.0 14.77850978098822 -6.717916041705378 3.959095954121041 1.1475806041444214 1.324708849645107 0.43552794589286226 0.10514170584557553 0.24888578874358946 8.178245946347225 0.03877320852400784 0.037324025669051845 1.914626026889043e-07 6.717916041705378 0.1771282455006855 TDESSPVLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TDESSPVLSPR 11 0 Q8NA72-3;Q8NA72 Q8NA72-3 POC5 Centrosomal protein POC5 1 TDESSPVLS(1)PR 126.34 0.0031766 18038000.0 38259.0 41167.0 38730.0 56594.0 50934.0 33066.0 32384.0 34816.0 37041.0 45093.0 True False 36132.71794291177 44324.37652723178 36238.15396603561 48885.79956990457 44535.21556426265 37620.541356737675 33889.92016767863 34917.30879590091 44450.235012013356 43791.04792431565 0.8251165399229581 1.012178941317821 0.8275242471627132 1.1163423093778029 1.0169936020081811 0.8590920551103846 0.7739006434888427 0.7973617999790442 1.0150530101229134 1.0 15.41834835359496 -6.778538874454584 24.8466208235363 0.8692177823610628 0.9639173582007705 0.08023523591383253 0.1090740408246216 452.2023853153839 657073.4609059934 0.03838002119682768 0.03393289534756262 1.665179767976006e-07 6.778538874454584 0.09469957583970767 TDEVPAGGSRS(ph)EAEDEDDEDYVPYVPLR ddPTM_A459_Selumetinib_30min_R1 3 TDEVPAGGSRSEAEDEDDEDYVPYVPLR 28 1 D6RGI7;A0A499FJW5;Q9UJV9;D6RD33 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 T(0.005)DEVPAGGS(0.201)RS(0.794)EAEDEDDEDYVPYVPLR;T(0.001)DEVPAGGS(0.414)RS(0.585)EAEDEDDEDYVPYVPLR;T(0.004)DEVPAGGS(0.185)RS(0.81)EAEDEDDEDYVPYVPLR 107.88 5.0503e-10 76420200.0 2701.6 3267.5 4032.7700000000004 4701.43 3689.79 3492.32 3016.13 2259.92 1395.42 2104.1400000000003 True False 2764.542023601494 2884.939580980463 3485.1419844199627 3880.4135072712197 3356.0491459853347 3457.1904315728534 2788.620885799805 2199.979580345278 2367.9258225555996 2374.226865059234 1.1643967408028304 1.215106956894992 1.4679060521594312 1.6343903627652736 1.413533472885543 1.4561331448360142 1.1745385105522477 0.9266088311617142 0.9973460655355371 1.0 11.213242080407813 -7.5071872184434385 3.3254626658890456 0.9738855485978275 1.3982161950586798 0.6899164328507196 0.12567811008245539 0.1552301424134398 3.571140701604419 0.07027579125112962 0.04092426330691735 3.110375207613894e-08 7.5071872184434385 0.4243306464608523 TDEVPAGGSRS(ph)EAEDEDDEDYVPYVPLR ddPTM_A459_Selumetinib_30min_R2 4 TDEVPAGGSRSEAEDEDDEDYVPYVPLR 28 1 D6RGI7;A0A499FJW5;Q9UJV9;D6RD33 D6RGI7 DDX41 Probable ATP-dependent RNA helicase DDX41 1 T(0.003)DEVPAGGS(0.171)RS(0.826)EAEDEDDEDYVPYVPLR;T(0.001)DEVPAGGS(0.189)RS(0.81)EAEDEDDEDYVPYVPLR;T(0.001)DEVPAGGS(0.19)RS(0.809)EAEDEDDEDYVPYVPLR;TDEVPAGGS(0.19)RS(0.809)EAEDEDDEDYVPYVPLR 91.503 6.3435e-06 25351100.0 54725.7 69092.0 71280.0 66819.0 70650.6 38618.4 30424.8 32213.1 26943.0 72236.0 True False 51684.26467833464 74391.13423420464 66693.922403796 57718.13693079576 61774.84000362221 43937.734057068825 31839.61348559748 32306.834787834196 32332.35285031927 70150.35898833207 0.7367640796668077 1.060452652089463 0.9507281696860458 0.822777499120081 0.8806061849789972 0.6263365532366966 0.4538767006294762 0.46053698446800123 0.4609007468614241 1.0 16.098162866279317 -6.809729022905209 3.3344785473116803 0.5471498370900936 0.9037391863774703 0.40957744575723565 0.17040763403284892 0.20178894496244326 4.586938632786819 0.059827458978021664 0.0541527753699076 1.54978330121219e-07 6.809729022905209 0.35658934928737673 TDGEPGPQGWS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TDGEPGPQGWSPR 13 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 1 TDGEPGPQGWS(1)PR;TDGEPGPQGWS(1)PR 161.49 0.00036364 35870000.0 68788.0 68975.0 74681.0 74233.0 79121.0 53252.0 56407.0 63659.0 50966.0 68006.0 True False 64965.038340181774 74265.16071041873 69876.1057665249 64122.33734093235 69181.1126292854 60586.97962647417 59030.03726835008 63844.23715068522 61160.624109021664 66042.49007919194 0.9836854767632447 1.1245057632043696 1.0580477156863113 0.970925494542118 1.0475242915027874 0.9173939316010642 0.8938190731083401 0.9667145662455977 0.9260799227237435 1.0 16.011106896487114 -6.382380204682942 1.3208512299087616 0.9377665325453307 1.055831007091561 0.4355379381699571 0.05077449000315694 0.37295750583621723 1.3295748348816157 0.020540529730142004 0.02607862589079149 4.1459092857723785e-07 6.382380204682942 0.11806447454623037 TDGFAEAIHS(ph)PQVAGVPR ddPTM_A459_Selumetinib_30min_R1 4 TDGFAEAIHSPQVAGVPR 18 0 P12270 P12270 TPR Nucleoprotein TPR 1 TDGFAEAIHS(1)PQVAGVPR;TDGFAEAIHS(1)PQVAGVPR;TDGFAEAIHS(1)PQVAGVPR;TDGFAEAIHS(1)PQVAGVPR 156.58 1.5297e-05 157853800.0 6819.3 8613.5 9038.1 9348.400000000001 7918.6 9330.8 16551.6 18989.0 16923.5 7682.5 True False 6978.176421952046 7605.02741569249 7810.775662729602 7715.877431201627 7202.364028142381 9236.940623688544 15303.09948623039 18485.35003503508 28717.943456464483 8668.623708887037 0.8049924251294989 0.8773050568449346 0.9010398795741967 0.8900925556719392 0.8308543858881021 1.0655602243086029 1.7653436116441088 2.1324434715148586 3.3128607747759276 1.0 13.081587243971194 -7.395570485091192 2.081378454410559 2.2895756664849265 0.8672622564111468 0.5466676748239759 0.5234173338700772 0.22463568533759679 1.901498923327072 0.26824324550336986 0.15457387618684792 4.021883763644158e-08 7.395570485091192 -1.4223134100737798 TDGFAEAIHS(ph)PQVAGVPR ddPTM_A459_Selumetinib_30min_R2 3 TDGFAEAIHSPQVAGVPR 18 0 P12270 P12270 TPR Nucleoprotein TPR 1 TDGFAEAIHS(1)PQVAGVPR;TDGFAEAIHS(1)PQVAGVPR;TDGFAEAIHS(1)PQVAGVPR 117.48 0.00067341 111515000.0 112589.0 103459.0 102844.0 128402.0 140672.0 73653.0 117265.0 136694.0 153846.0 206527.0 True False 106331.75410947728 111393.97262688252 96227.1290080806 110913.42609419514 122999.52573636378 83798.03219463499 122718.05485618938 137091.75690909 184619.49881639815 200564.02888841098 0.5301636325257393 0.5554035449141255 0.47978258883909375 0.5530075692481462 0.6132681239904578 0.41781187114693535 0.6118647273707628 0.6835311280337542 0.9205015467609898 1.0 17.61370335656968 -8.15190993776077 1.6071556215480323 1.0029979587331868 0.5299426255161653 0.9149975816073403 0.05161269178868504 0.09638372663999561 0.44971906843344006 0.04665400188810944 0.014532167082782186 7.048392205291555e-09 8.15190993776077 -0.4730553332170214 TDGS(ph)ISGDRQPVTVADYISR ddPTM_A459_Selumetinib_30min_R2 2 TDGSISGDRQPVTVADYISR 20 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 T(0.035)DGS(0.852)IS(0.1)GDRQPVT(0.012)VADY(0.001)ISR;T(0.176)DGS(0.787)IS(0.037)GDRQPVTVADYISR 97.776 0.00059048 55114000.0 42261.0 41481.0 40179.0 41612.0 45572.0 41525.0 38565.0 37357.0 25900.0 49171.0 True False 39912.30280418709 44662.459317562694 37593.92688358754 35944.37381529611 39846.83794115087 47244.69182358104 40358.348915097755 37465.70268521571 31080.723706464334 47751.3054683992 0.8358368931002359 0.935313890991302 0.7872858451684929 0.7527411756121166 0.8344659386856065 0.9893905802187245 0.8451779175295229 0.7846005950561857 0.6508874134767456 1.0 15.543252554939519 -10.496092710481905 4.408008109727654 1.0000047236008804 0.8287081383767859 0.260511425732986 0.08865175133686667 21440919.309640758 10210773.708028022 986.9372844095291 0.02264242073062996 3.1908566181869425e-11 10.496092710481905 -0.17129658522409452 TDGS(ph)QKTESSTEGKEQEEK ddPTM_A459_Selumetinib_30min_R1 1 TDGSQKTESSTEGKEQEEK 19 2 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 T(0.055)DGS(0.934)QKT(0.011)ESSTEGKEQEEK 72.932 0.01354 6046200.0 588.15 645.08 1068.6 1123.3 572.35 792.34 934.79 856.83 479.9 780.27 True False 601.8527506593196 569.5537337104439 923.4899893996364 927.1367419525042 520.5810435565999 784.3697789871591 864.2780376962538 834.1040850239143 814.355249490786 880.4252549734179 0.6835932377672321 0.646907537571307 1.048913561012648 1.0530555963896069 0.5912836332396183 0.8908987725605861 0.98165975227772 0.9473877314538165 0.9249567125551996 1.0 9.782056719263998 -5.245247164207222 24.68739665071409 0.9206697410124444 0.6652503241267852 0.4182857770446283 0.12440749533897445 722.538769851881 1101610.5564674223 0.03324909754209556 0.08735351694928334 5.685292792935647e-06 5.245247164207222 -0.25541941688565917 TDGSIS(ph)GDRQPVTVADYISR ddPTM_A459_Selumetinib_30min_R1 3 TDGSISGDRQPVTVADYISR 20 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TDGS(0.166)IS(0.766)GDRQPVT(0.068)VADYISR;TDGS(0.319)IS(0.657)GDRQPVT(0.023)VADYISR;T(0.001)DGS(0.074)IS(0.461)GDRQPVT(0.461)VADY(0.002)ISR 143.43 0.00019714 143598000.0 7204.6 8070.1 8976.5 8785.7 7533.1 8068.099999999999 7404.5 6869.4 4339.9 7025.199999999999 True False 7372.453162288761 7125.248940312297 7757.5406043850235 7251.442423014438 6851.7324350768295 7986.942239248683 6845.972603602847 6687.201197044078 7364.493326245182 7926.952851242848 0.9300488221186848 0.8988635449238412 0.9786283266676347 0.9147830899331642 0.8643589237448994 1.0075677740402391 0.8636323101795015 0.8436029988491237 0.9290446738421714 1.0 12.952550680070283 TDGSIS(ph)GDRQPVTVADYISR ddPTM_A459_Selumetinib_30min_R2 2 TDGSISGDRQPVTVADYISR 20 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 T(0.008)DGS(0.065)IS(0.926)GDRQPVT(0.001)VADYISR;T(0.001)DGS(0.111)IS(0.843)GDRQPVT(0.045)VADYISR 169.58 1.046e-08 39674000.0 161863.0 128939.0 154547.0 167928.0 168665.0 137488.0 122832.0 134240.0 107058.0 168372.0 True False 152867.3024489277 138828.20669576933 144603.61427805093 145055.91670804186 147475.79481576875 156425.72400820014 128543.93138699056 134630.61617537166 128472.59145045007 163510.66287700713 0.9349072394374343 0.8490468098719411 0.8843681001209194 0.8871342954382924 0.9019338079908598 0.9566698663919166 0.7861501453497344 0.8233751475684551 0.7857138439166336 1.0 17.319025194430388 -7.267074123108838 24.99216152778399 0.8340910497948504 0.8983937894027285 0.12950033426943464 0.06307121707418359 778.1458670244596 3451346.061870124 0.024495258121663165 0.01703707747770325 5.406620377039476e-08 7.267074123108838 0.06430273960787813 TDGSQKT(ph)ESSTEGKEQEEK ddPTM_A459_Selumetinib_30min_R1 1 TDGSQKTESSTEGKEQEEK 19 2 D6REM6;A0A0R4J2E8;A8MXP9;P43243;B3KM87;P43243-2 D6REM6 MATR3 Matrin-3 1 T(0.019)DGS(0.093)QKT(0.853)ES(0.036)S(0.001)TEGKEQEEK 82.755 0.016074 4539600.0 522.95 506.01 973.69 1052.3 527.19 698.11 542.26 463.96 448.87 451.61 True False 535.133717516435 446.766113962333 841.4682460963239 868.5355591174394 479.5057575829544 691.0876472331644 501.3568916239695 451.65427364552505 761.699605832317 509.5785425539177 1.0501496292101298 0.876736511948129 1.65130235248728 1.7044194105279482 0.9409849857094771 1.3561945598603016 0.9838657827138035 0.886329065941265 1.4947638925587665 1.0 8.993160719325754 -7.259489457688008 24.965790768090447 1.0817671088397496 1.2687638905172913 0.07436063527386838 0.29626426083641094 509.61203081673574 6524862.964446559 0.12325837092279834 0.09060940052891854 5.501872759083997e-08 7.259489457688008 0.18699678167754175 TDHGAEIVYKS(ph)PVVSGDT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 2 TDHGAEIVYKSPVVSGDTSPR 21 1 A0A0G2JQJ7;A0A0G2JPD5;A0A0G2JS76;A0A0G2JMX7;P10636;P10636-9;I3L170;P10636-3;P10636-4;P10636-5;P10636-7;P10636-8;P10636-2;P10636-6 A0A0G2JQJ7;P10636-2 MAPT Microtubule-associated protein tau;Microtubule-associated protein 2 TDHGAEIVY(0.001)KS(0.996)PVVS(0.398)GDT(0.557)S(0.048)PR;TDHGAEIVY(0.035)KS(0.959)PVVS(0.122)GDT(0.474)S(0.41)PR 81.94 0.0024568000000000003 10175700.0 52714.0 39348.0 44476.0 42521.0 49972.0 37970.0 39100.0 37713.0 33755.0 45235.0 True False 49784.366910861514 42365.865076238675 41614.462581807406 36729.566447183664 43694.07060465178 43200.02284265796 40918.227475180145 37822.73858627677 40506.943193502084 43928.948015355345 1.133292945996781 0.964417929184867 0.9473129783863954 0.8361130440534306 0.9946532429908983 0.9834067236838318 0.9314638597964421 0.8609980501480674 0.9221013710445081 1.0 15.422884330580347 -4.7134730724438585 2.5506590961330633 0.9302439731362093 1.200251466373469 0.575069889474925 0.05086680968494729 0.4888083099339896 3.444336087025648 0.013541464975184932 0.3101659489337385 1.9343137881384747e-05 4.7134730724438585 0.2700074932372596 TDKS(ph)SASAPDVDDPEAFPALA ddPTM_A459_Selumetinib_30min_R1 1 TDKSSASAPDVDDPEAFPALA 21 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 T(0.176)DKS(0.724)S(0.097)AS(0.002)APDVDDPEAFPALA 120.33 4.0679e-05 7648700.0 3075.8 3985.9 3817.5 3872.5 3225.6 3381.5 3545.1 3217.0 2020.7 3169.6 True False 3147.460155535042 3519.2289750053633 3299.104468026494 3196.240570827981 2933.8450495259335 3347.4851801563464 3277.690252823615 3131.6747097113016 3428.980313911297 3576.4490345184954 0.8800517287278472 0.9840008737826637 0.9224525321582443 0.8936910717807272 0.8203234608433119 0.9359801154295003 0.9164649687968773 0.8756380083948059 0.9587667210733641 1.0 11.804312167492993 -8.495797707995681 4.623639981946071 0.999812550110321 0.9055246446113543 0.37754539591969494 0.040574469680717394 0.18557387057090405 10.799727276599594 0.04061023702961742 0.010589735851603848 3.193024802330276e-09 8.495797707995681 -0.0942879054989667 TDLANGSLSSSPEEMS(ph)GAEEGR ddPTM_A459_Selumetinib_30min_R2 2 TDLANGSLSSSPEEMSGAEEGR 22 0 Q5TAQ8;V9GY54;Q5TAQ9-2;Q5TAQ9;Q5TAQ6;Q5TAQ7;Q5TAQ5 Q5TAQ8 DCAF8 DDB1- and CUL4-associated factor 8 1 TDLANGSLSS(0.003)S(0.005)PEEMS(0.992)GAEEGR;TDLANGSLSSSPEEMS(1)GAEEGR 229.55 1.1710999999999998e-57 2238800.0 13399.5 12147.6 14162.2 15076.3 16044.300000000001 13500.0 12822.2 13991.7 12816.1 11120.6 True False 12654.809432448465 13079.281859309658 13251.01947063748 13022.881931931866 14028.671596138125 15359.502459201545 13418.457706707291 14032.413530549367 15379.67811175357 10799.51938321124 1.1717937607595232 1.211098512369217 1.2270008507264965 1.2058760644642232 1.299008881631054 1.4222394454959895 1.2425050810656826 1.299355372458883 1.4241076446107936 1.0 13.398679488337592 -6.264243443445346 8.37568067185828 1.3013551749062362 1.2060194997626703 0.08637089733669656 0.11207332113793528 0.22989490454305614 201.86041129215232 0.032106659987946824 0.03859042688529479 5.441975178192993e-07 6.264243443445346 -0.09533567514356589 TDLEKDIISDTSGDFR ddPTM_A459_Selumetinib_30min_R1 3 TDLEKDIISDTSGDFR 16 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;; 160.63 0.00014855 96033000.0 20764.3 26787.1 26207.0 30083.9 24178.6 23442.5 21453.2 21128.699999999997 13609.0 17666.300000000003 False True 21248.067789705543 23650.853879015052 22648.233344746663 24830.311609743545 21991.649899078526 23206.689734086987 19834.967851929592 20568.29824030996 23093.479037966456 19933.94168933433 1.0659240465760136 1.1864614759894407 1.1361643220249118 1.245629790470844 1.1032263584299122 1.164179673832584 0.9950349088530899 1.0318229360184716 1.1585003808013865 1.0 14.282939392957005 -7.2459929499634805 24.759850504469142 1.048991467423146 1.1534654128036586 0.4060602666159492 0.06146789997617522 709.7626712452819 1137715.2717854804 0.022999637018566162 0.01775155969414355 5.675538186102752e-08 7.2459929499634805 0.10447394538051258 TDLEKDIISDTSGDFR ddPTM_A459_Selumetinib_30min_R2 3 TDLEKDIISDTSGDFR 16 1 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;; 113.43 0.0064062 42732900.0 363170.0 356789.0 372455.0 372762.0 354832.0 196915.0 249206.0 256348.0 162429.0 345484.0 False True 342986.46528469777 384153.5690425457 348491.6507983422 321991.172549683 310254.83192167245 224038.25383360535 260794.57279232066 257093.9302393042 194919.33864545557 335508.9792447666 1.02228699230871 1.1449874453651836 1.038695451855863 0.9597095531526093 0.9247288481520184 0.667756357334809 0.7773102626921382 0.7662803267382731 0.5809660864642746 1.0 18.35599185230354 -6.317174107680561 1.5203882252955587 0.7449215353936142 1.0757703490453363 0.5981268233810876 0.1090043579348365 0.2454982448127542 1.1349087945679148 0.03913208329339601 0.05111160057371199 4.817546245614318e-07 6.317174107680561 0.33084881365172214 TDLEKDIISDTSGDFRK ddPTM_A459_Selumetinib_30min_R1 1 TDLEKDIISDTSGDFRK 17 2 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 67.846 0.024054 72031000.0 4003.9 3913.0 6511.8 6587.7 5049.6 4414.2 3999.4 3923.7 2740.7 3101.9 False True 4097.183079766813 3454.864140895653 5627.533326757023 5437.281861444412 4592.86457157929 4369.797155772921 3697.722038064586 3819.6307300261833 4650.767727191909 3500.0590800646514 1.1706039772594727 0.9870873782027234 1.6078395244268489 1.5534828804501144 1.3122248700711796 1.2484923985032286 1.0564741775719635 1.0913046444792094 1.3287683495634028 1.0 11.773163559233096 -7.0025655282020205 3.4813123511170945 1.1274085900952322 1.334341058364735 0.21998276135774286 0.18287008279787265 0.42153140675619616 10.863129925209293 0.07777876819866524 0.06339071805019193 9.941100670734374e-08 7.0025655282020205 0.20693246826950285 TDLETS(ph)PGAAPR ddPTM_A459_Selumetinib_30min_R2 1 TDLETSPGAAPR 12 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 1 TDLET(0.128)S(0.872)PGAAPR 159.44 0.00046346 3576000.0 34633.0 42253.0 54661.0 55116.0 52645.0 41470.0 30577.0 34993.0 28463.0 40186.0 True False 32708.236506883663 45493.66923519144 51144.17077039693 47609.105719596795 46031.26444772861 47182.116072821336 31998.891087176067 35094.823836596974 34156.395322667755 39025.725764232746 0.8381198777566594 1.1657353795297407 1.3105245262926228 1.2199415843594832 1.1795107854193059 1.2090003490995664 0.8199435234207276 0.8992740852179497 0.875227677481715 1.0 15.252137841905697 -7.258031946829723 24.993616983383504 0.8902174906314537 1.165645905273937 0.5075130220370159 0.12271118491215761 241.85407750578983 1774014.2724057303 0.04964986609711462 0.036860162249628785 5.5203682979571574e-08 7.258031946829723 0.27542841464248324 TDLGES(ph)TASLDSIVR ddPTM_A459_Selumetinib_30min_R2 1 TDLGESTASLDSIVR 15 0 A0A6I8PL36;A0A6I8PRU0;Q9NYQ6 A0A6I8PL36 CELSR1 Cadherin EGF LAG seven-pass G-type receptor 1 1 T(0.02)DLGES(0.436)T(0.436)AS(0.108)LDSIVR 95.195 0.010976 1525300.0 7282.5 3897.5 5666.2 5383.2 5343.7 4827.7 11118.0 5975.8 5533.0 5283.5 True False 6877.767804157319 4196.425717562269 5301.642860892096 4649.998873462032 4672.376632715874 5492.671853502764 11635.009029899056 5993.1885886530545 6639.754604936959 5130.951626818392 1.340446822419586 0.8178649932360393 1.033266973943301 0.9062644148031874 0.9106257420737229 1.0704976879520238 2.2676123019919623 1.1680462075159574 1.2940590923197124 1.0 12.325010708928858 -7.027798743683294 24.999749444893986 1.4782363714489921 0.9881961847930316 0.2659229152897683 0.3390896910446103 860.4439104202091 773805.2650252439 0.12535125502425318 0.09734157867533495 9.379965830286789e-08 7.027798743683294 -0.4900401866559605 TDLGESTAS(ph)LDSIVR ddPTM_A459_Selumetinib_30min_R2 1 TDLGESTASLDSIVR 15 0 A0A6I8PL36;A0A6I8PRU0;Q9NYQ6 A0A6I8PL36 CELSR1 Cadherin EGF LAG seven-pass G-type receptor 1 1 TDLGES(0.129)T(0.1)AS(0.765)LDS(0.005)IVR 96.489 0.01014 1965300.0 7756.5 5619.7 5129.7 4527.3 4774.7 6156.8 9648.6 6366.9 5560.4 6176.0 True False 7325.424781729659 6050.712919816471 4799.660686795065 3910.6739299718856 4174.859499640416 7004.843314134232 10097.279018338191 6385.426624902963 6672.635370556921 5997.6828328249 1.221375818947631 1.0088417624722237 0.8002525009370046 0.6520307990561021 0.6960787384073898 1.1679249319082383 1.6835300064679124 1.0646489324103583 1.1125355502358432 1.0 12.550189516837213 -6.896231391770284 6.59458789341128 1.2484176043416593 0.8681999447116049 0.3365999565458966 0.23010107421093093 0.24520360857123 13.676317083820715 0.08652215237904999 0.07628869015746376 1.26989732459989e-07 6.896231391770284 -0.3802176596300544 TDLQGS(ph)ASPSKVEGVHTPR ddPTM_A459_Selumetinib_30min_R2 2 TDLQGSASPSKVEGVHTPR 19 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 T(0.097)DLQGS(0.55)AS(0.352)PS(0.002)KVEGVHTPR;T(0.001)DLQGS(0.434)AS(0.282)PS(0.282)KVEGVHTPR 93.753 0.0010782 7403500.0 41878.0 44111.0 43388.0 43451.0 44891.0 33110.3 38255.0 37835.0 25672.7 37667.0 True False 39550.58841091662 47494.171860779796 40596.46331728257 37532.89884284419 39251.3912493681 37670.943279622305 40033.93330084442 37945.093586078576 30807.957355171686 36579.455839380746 1.0812240779245603 1.2983837722825957 1.109815944106451 1.0260649859760074 1.0730447008758068 1.029838810206315 1.094437639439804 1.037333462605193 0.8422202202910964 1.0 15.15874599308151 -6.064379251390131 0.42104520633055115 0.9601221736036492 1.2324022428223773 0.4344620184180127 0.08054449276832731 1.9065635994691994 0.5565828361619026 0.07549391073635474 0.23564714795453232 8.622252732803307e-07 6.064379251390131 0.27228006921872816 TDLQGSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 TDLQGSASPSK 11 0 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 T(0.014)DLQGS(0.006)AS(0.881)PS(0.099)K;T(0.002)DLQGS(0.001)AS(0.705)PS(0.292)K 127.78 0.0029026 4875400.0 4871.0 6482.5 3821.7 4054.6000000000004 4156.9 3704.2 4921.5 4217.5 2402.9 5165.0 True False 4984.4848226839185 5723.525886367512 3302.7341310954434 3346.5402242683385 3780.9091289603007 3666.939111144503 4550.26729267762 4105.638199629286 4077.545799127756 5827.978061360431 0.8552682886250236 0.982077459130219 0.5667032539110971 0.5742197703961762 0.6487514347433421 0.6291957643863412 0.780762598069123 0.7044704280631596 0.6996501627488848 1.0 12.50877973124329 -10.857222729448356 11.73102771256086 1.0000000044695965 0.7120434761848289 0.32720550261274906 0.12221036853727851 1.5564951465325128e-08 8.184983028894251e-10 0.12887353000082966 0.03125642168363332 1.3892399718916361e-11 10.857222729448356 -0.2879565282847676 TDLQGSAS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 TDLQGSASPSK 11 0 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 T(0.04)DLQGS(0.072)AS(0.781)PS(0.107)K;T(0.334)DLQGS(0.001)AS(0.656)PS(0.008)K 134.04 0.0017047999999999998 29628000.0 212470.0 155213.0 155732.0 172562.0 184859.0 163350.0 207883.0 213172.0 157468.0 144554.0 True False 200661.76798479995 167117.3380115442 145712.37266818108 149058.7579139466 161635.35975957205 185849.97975633855 217549.97141234958 213792.29522747555 188966.00002353344 140380.35042360262 1.4294149243772083 1.1904610403611458 1.037982682252102 1.061820671227537 1.15141014587748 1.323903090393561 1.5497181105182094 1.5229502888570219 1.3461000735026087 1.0 17.098981484649478 -6.879993663765175 4.212069447150476 1.402690594695017 1.1615994034952792 0.18003219346441268 0.17324883759942117 0.28590763934473673 9.069633486648842 0.06280779151315072 0.05526116481403208 1.3182759716932205e-07 6.879993663765175 -0.24109119119973776 TDLQGSAS(ph)PSKVEGVHTPR ddPTM_A459_Selumetinib_30min_R1 1 TDLQGSASPSKVEGVHTPR 19 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 TDLQGS(0.052)AS(0.474)PS(0.474)KVEGVHTPR 221.9 1.0140999999999999e-18 6115100.0 1134.6 1050.9 1068.0 1198.5 1083.9 903.98 992.0 867.96 416.63 732.8 True False 1161.0339724527148 927.8601394498447 922.971466104073 989.2044736313327 985.8614363780874 894.8867819481688 917.1726413362179 844.9388812685794 706.9906805487517 826.8620180764618 1.4041447630568893 1.1221462821672907 1.1162339615637342 1.1963356061904136 1.1922925649330316 1.0822685797443614 1.1092209114524896 1.0218620069575453 0.8550286082718274 1.0 9.69150279070045 -7.477432268118593 0.9160436645354796 0.9305768513093351 1.2024106553710923 0.5986629577864184 0.0865344882967676 0.4256356117227496 0.664931122546091 0.07146230098939804 0.03531593863620756 3.330947071824123e-08 7.477432268118593 0.27183380406175717 TDLQGSAS(ph)PSKVEGVHTPR ddPTM_A459_Selumetinib_30min_R2 1 TDLQGSASPSKVEGVHTPR 19 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 T(0.001)DLQGS(0.098)AS(0.651)PS(0.25)KVEGVHTPR 59.182 0.018729 72591000.0 338770.0 331340.0 340550.0 361350.0 405200.0 272880.0 288100.0 287890.0 227300.0 310150.0 True False 319942.5196037586 356752.71257397893 318639.3837628042 312133.50663648156 354295.15346603945 310466.74304199393 301497.22085931944 288727.7122372449 272766.3512926387 301195.16363352386 1.0622432171356024 1.1844569755710093 1.0579166674485698 1.0363164629571104 1.1762976177702655 1.0307826304267993 1.0010028621381288 0.9586067344313383 0.9056133172992259 1.0 18.20033907891561 -7.2367060684336275 1.9794284150098258 0.9524410302568582 1.1014357379626574 0.6065520078354998 0.05178061593213306 0.22704230636457787 1.7384108192336047 0.02584461721012975 0.01674055472292912 5.798209879211654e-08 7.2367060684336275 0.14899470770579915 TDLQGSASPS(ph)KVEGVHTPR ddPTM_A459_Selumetinib_30min_R1 2 TDLQGSASPSKVEGVHTPR 19 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 TDLQGS(0.001)AS(0.017)PS(0.959)KVEGVHT(0.023)PR;TDLQGS(0.001)AS(0.044)PS(0.954)KVEGVHTPR 87.323 0.0014475 53936000.0 9558.4 9346.5 12712.3 13413.4 11852.3 9993.2 10443.0 9018.6 4209.6 7626.8 True False 9781.09212259124 8252.207434930027 10986.039483665549 11071.00149070214 10780.261557693519 9892.677481099634 9655.276102292468 8779.397431458601 7143.3837429806445 8605.774071323087 1.136573193942501 0.9589151849139004 1.2765893448532644 1.286462019447373 1.2526777333855939 1.1495395299842788 1.1219532400306236 1.020175217092217 0.8300687054735091 1.0 13.07108925015627 -7.826378419864071 2.2476733921272967 0.9151880636182129 1.1776399437097342 0.5356284345166793 0.09698788451552058 0.25913481313157355 2.5601284694118625 0.07466775748548485 0.029870796663557422 1.4914942387499223e-08 7.826378419864071 0.2624518800915213 TDLQGSASPS(ph)KVEGVHTPR ddPTM_A459_Selumetinib_30min_R2 2 TDLQGSASPSKVEGVHTPR 19 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 T(0.001)DLQGS(0.011)AS(0.03)PS(0.959)KVEGVHTPR;TDLQGSAS(0.006)PS(0.954)KVEGVHT(0.04)PR 73.735 0.0045777000000000005 88738000.0 338590.0 310460.0 358690.0 388360.0 383800.0 287841.0 279321.0 277205.0 197322.0 311730.0 True False 319772.5232831616 334271.2837137604 335612.2759121427 335464.69804163254 335583.61278446624 327488.48498955776 292309.9799640613 278011.62065624166 236791.9136373346 302729.54492819065 1.056297704140551 1.1041911478876356 1.1086208185981716 1.1081333277900143 1.1085261363044985 1.0817856746266377 0.9655812749740005 0.9183498119491038 0.782189639579127 1.0 18.2076699564782 -7.435694679203726 2.0645023157973146 0.8855453628299413 1.0995315431455102 0.7481106633321195 0.05162735689777 0.14951039332950922 1.24860001836165 0.027392766076927137 0.015238192497420262 3.6669528077501224e-08 7.435694679203726 0.21398618031556882 TDLQGSASPSKVEGVHT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TDLQGSASPSKVEGVHTPR 19 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 TDLQGSASPS(0.071)KVEGVHT(0.929)PR 77.13 0.004703100000000001 7401700.0 4703.0 4669.2 6923.9 7909.3 7466.4 5137.8 5057.1 4317.2 2399.9 3309.6 True False 4812.570749555012 4122.527893347811 5983.6724102602875 6528.08923094894 6791.065438299987 5086.118396749156 4675.63887550543 4202.693831758045 4072.4550182390863 3734.4193982339743 1.2887065528394859 1.1039273990750411 1.6023032691748538 1.7480867933676936 1.8185063631341236 1.3619569347659255 1.2520390392457161 1.125394173387574 1.0905189224769374 1.0 11.866668244838642 -7.402936772124832 2.033923856955401 1.0789064847107115 1.507874498209866 0.477975417558937 0.1984972405099609 0.3508464528408927 2.836439378588869 0.12593330751170906 0.07172319429408913 3.954241847210124e-08 7.402936772124832 0.4289680134991545 TDMDNQIVVSDYAQMDR ddPTM_A459_Selumetinib_30min_R1 2 TDMDNQIVVSDYAQMDR 17 0 P50991-2;P50991 P50991-2 CCT4 T-complex protein 1 subunit delta 0 ; 178.84 7.4361e-08 0.0 1235.22 1527.97 1402.6399999999999 1341.48 1618.08 1115.49 1410.13 1385.0 786.7 1268.55 False True 1263.9982226802763 1349.074562066019 1212.1691921500149 1107.2157006983405 1471.7249496952256 1104.269183383884 1303.7627587978234 1348.2653008859654 1334.9724417053583 1431.3807492233834 0.8830621924781907 0.9424987466109065 0.846853077217711 0.7735298251699113 1.0281855128299942 0.7714713111679204 0.9108427366409664 0.9419333756007872 0.9326466367733862 1.0 10.48319176661624 -8.235354109842064 1.066282984486812 0.9938360582759659 0.8772600282061644 0.2200208934757938 0.07213295827263198 0.747510517572237 1.7119402907806702 0.0660341589485099 0.0224112256478485 5.816287828548332e-09 8.235354109842064 -0.11657603006980144 TDNSSLS(ph)SPLNPK ddPTM_A459_Selumetinib_30min_R1 2 TDNSSLSSPLNPK 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 T(0.002)DNS(0.012)S(0.04)LS(0.825)S(0.121)PLNPK;TDNS(0.004)S(0.015)LS(0.785)S(0.196)PLNPK 105.19 0.007384799999999999 31132500.0 3367.2 4384.9 3899.3 4056.7 3245.5 3548.3999999999996 3592.9 3162.1000000000004 2051.5 3057.8999999999996 True False 3445.6492085693462 3871.513869515296 3369.796477321732 3348.273498690221 2951.9450980395636 3512.7063176894185 3321.884660339616 3078.2308360516327 3481.245664368301 3450.411251468355 0.9986198622274425 1.1220441817965139 0.9766361838426312 0.9703983828783689 0.8555342777714788 1.018054388790482 0.9627503558962591 0.8921344766487364 1.008936445731454 1.0 11.752552610348394 -5.434924204827267 5.9570014749318085 0.9536096898293144 1.0598689940130783 0.3425509377931385 0.05548085235771086 0.2233808593059297 12.073350432816811 0.014009444661660332 0.029487080051320072 3.6734640597476093e-06 5.434924204827267 0.10625930418376395 TDNSSLS(ph)SPLNPK ddPTM_A459_Selumetinib_30min_R2 4 TDNSSLSSPLNPK 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 TDNS(0.017)S(0.017)LS(0.483)S(0.483)PLNPK;TDNSS(0.005)LS(0.498)S(0.498)PLNPK;TDNSS(0.003)LS(0.499)S(0.499)PLNPK;TDNSS(0.025)LS(0.753)S(0.222)PLNPK 177.93 0.00010533 61826000.0 290722.0 260447.0 278055.0 299169.0 291440.0 250426.0 315797.0 294866.0 231914.0 282613.0 True False 274564.83509237564 280422.44743090135 260165.2440233933 258421.66610468904 254826.70169334253 284919.90835911187 330482.18623988447 295724.011242306 278303.28021857055 274453.2283732421 1.000406651143421 1.021749494779276 0.9479401848011134 0.9415872702114805 0.9284886288413103 1.0381364797488761 1.2041475634983092 1.0775023962922263 1.0140280800052845 1.0 18.06620078416529 -6.981074227523504 8.92186806346439 1.0861712758742639 0.9697514332742281 0.4270400658573249 0.05765499287298941 0.19696657176666568 81.24507691933574 0.021154659527135137 0.018430790968626043 1.0445416759252808e-07 6.981074227523504 -0.1164198426000358 TDNSSLSS(ph)PLNPK ddPTM_A459_Selumetinib_30min_R1 1 TDNSSLSSPLNPK 13 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 T(0.002)DNS(0.007)S(0.007)LS(0.4)S(0.584)PLNPK 77.91199999999998 0.042159 4839400.0 2527.8 4091.4 3179.6 3437.4 2736.9 2755.5 2884.7 2563.6 1706.3 2219.6 True False 2586.692821757422 3612.3769859597414 2747.827784292611 2837.1226179894406 2489.3478782389425 2727.782171793823 2667.1047565147046 2495.6050002536176 2895.466476778763 2504.507280734873 1.0328150537451957 1.4423503631819339 1.0971530430074625 1.1328066960767516 0.9939471517561401 1.0891492281840909 1.0649219417450135 0.9964454962659789 1.156102239770361 1.0 11.290311090254638 -5.495974946280651 24.40011056687566 1.0644054248437749 1.245625015861242 0.30041514941185377 0.1055554278614599 552.9816111081783 501519.18631375744 0.02534144648308781 0.052487051332773656 3.191721974870795e-06 5.495974946280651 0.1812195910174672 TDNSVASS(ph)PSSAISTATPSPK ddPTM_A459_Selumetinib_30min_R2 1 TDNSVASSPSSAISTATPSPK 21 0 H0Y6I7;F5H5V6;F5H6S1;F8W8R6;A0A087X0R0;O15550 H0Y6I7 KDM6A Lysine-specific demethylase 6A 1 TDNSVAS(0.008)S(0.861)PS(0.101)S(0.03)AISTATPSPK 241.92 3.2273e-31 3941400.0 41613.0 40804.0 37888.0 42287.0 43407.0 31309.0 34393.0 34697.0 25571.0 35276.0 True False 39300.31605003757 43933.53559446076 35450.32732933532 36527.437650856176 37953.82459649643 35621.530555195626 35992.34264843661 34797.962525602416 30685.91451343629 34257.49022194484 1.1472035982619173 1.2824505038117937 1.034819745978541 1.0662613464735733 1.1078985748986296 1.0398172873848477 1.050641550658035 1.0157767629839782 0.895743217457867 1.0 15.064131839874277 -5.108728206575135 0.33681429234831595 0.9632549941361119 1.355365257214028 0.5769257958422866 0.06270006395325138 3.938942124362051 0.4260790329716949 0.06491005574244793 0.6206791931752695 7.785236200951824e-06 5.108728206575135 0.3921102630779161 TDNSVASSPSSAIS(ph)TATPSPK ddPTM_A459_Selumetinib_30min_R2 1 TDNSVASSPSSAISTATPSPK 21 0 H0Y6I7;F5H5V6;F5H6S1;F8W8R6;A0A087X0R0;O15550 H0Y6I7 KDM6A Lysine-specific demethylase 6A 1 TDNSVASSPS(0.002)S(0.002)AIS(0.279)T(0.279)AT(0.279)PS(0.159)PK 74.96600000000002 0.0031223 5902200.0 20916.0 21580.0 22644.0 20332.0 24129.0 14660.0 22024.0 23270.0 12038.0 19985.0 True False 19753.572453382007 23235.116609363387 21187.10969292308 17562.746525343668 21097.699304003094 16679.281929769983 23048.159639728066 23337.711847444116 14445.936369823077 19407.98112273408 1.0178066604899523 1.1971938998923637 1.0916699454177112 0.9049239286806114 1.0870630577484288 0.8594032436600137 1.1875609056899774 1.202480139477611 0.7443296795513381 1.0 14.244362431876942 -5.543430745336912 24.65609068337594 1.011168595148475 1.1167332372715408 0.09955798261249882 0.139779506706235 457.76187023023954 549170.9529468539 0.03727626307975756 0.06457240405441764 2.861338606908123e-06 5.543430745336912 0.10556464212306582 TDNSVASSPSSAISTATPS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TDNSVASSPSSAISTATPSPK 21 0 H0Y6I7;F5H5V6;F5H6S1;F8W8R6;A0A087X0R0;O15550 H0Y6I7 KDM6A Lysine-specific demethylase 6A 1 TDNSVASSPSSAIS(0.001)T(0.014)AT(0.209)PS(0.777)PK 240.91 4.041799999999998e-68 0.0 820.69 920.22 1170.6 1253.2 694.64 694.23 746.41 942.76 502.29 907.44 True False 839.8104802152465 812.4802146013284 1011.6389496455306 1034.3521454775025 631.8099346486526 687.2466765104065 690.1076927618617 917.7549422839372 852.3494441898872 1023.9187632141161 0.820192490250938 0.7935006601997654 0.9880070431270946 1.0101896582406944 0.6170508416755442 0.6711925801155509 0.6739867629689585 0.8963161680943057 0.8324385437711221 1.0 9.999885542424535 -6.250948599196265 24.99519381481802 0.7657225062794429 0.9012269374667957 0.1798849307816447 0.12386343751500781 1201.4068800337022 2862455.5241021626 0.03849811136468709 0.049176260021074454 5.611143826407661e-07 6.250948599196265 0.13550443118735278 TDNSVASSPSSAISTATPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 TDNSVASSPSSAISTATPSPK 21 0 H0Y6I7;F5H5V6;F5H6S1;F8W8R6;A0A087X0R0;O15550 H0Y6I7 KDM6A Lysine-specific demethylase 6A 1 TDNSVASSPSSAISTAT(0.045)PS(0.955)PK 179.85 2.9698e-14 9184300.0 69687.0 58670.0 57516.0 56896.0 54553.0 38947.0 45930.0 50279.0 28448.0 56389.0 True False 65814.07551916393 63169.80034621634 53815.48317868592 49146.66664892549 47699.5644299922 44311.595724335006 48065.836008568396 50425.30356586344 34138.39490353271 54760.90305378297 1.201844232819265 1.153556585510919 0.9827354951731072 0.897477285950827 0.8710514577004778 0.8091830713751148 0.8777400175698515 0.9208267350218575 0.623408179919969 1.0 15.740858617607495 -5.36777806033116 1.2858485157143826 0.844250558733383 1.236387643541703 0.6681721799430018 0.09059815891605347 0.3473563408696719 0.9360608830886039 0.027669767915226105 0.13589683895831653 4.287675796476981e-06 5.36777806033116 0.39213708480832 TDNVSDFSES(ph)SDSENSNKR ddPTM_A459_Selumetinib_30min_R1 1 TDNVSDFSESSDSENSNKR 19 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 TDNVSDFSES(0.499)S(0.499)DS(0.002)ENSNKR 93.407 0.0010458 6826600.0 2602.7 2934.7 2795.7 2750.9 2510.5 2311.3 2227.6 2580.2 1245.6 2061.6 True False 2663.337846027394 2591.1039596949836 2416.059295680856 2270.50695578843 2283.425718264775 2288.0504204924914 2059.5703385489514 2511.7647143292174 2113.6922249754584 2326.2264416845433 1.1449177080537054 1.1138657498100781 1.0386174159086852 0.9760472648330126 0.9816007923163429 0.9835888628432894 0.8853696706574739 1.0797593343966618 0.9086356285438929 1.0 11.183775824463126 -5.365997727399159 1.6483864383248483 0.972355619408064 1.1488744310074916 0.616573882597698 0.04923633315822981 0.2790864396497946 1.3505620013130415 0.013836203356504775 0.0539152982678437 4.305288633817148e-06 5.365997727399159 0.17651881159942762 TDNVSDFSES(ph)SDSENSNKR ddPTM_A459_Selumetinib_30min_R2 1 TDNVSDFSESSDSENSNKR 19 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 T(0.001)DNVS(0.011)DFS(0.064)ES(0.46)S(0.46)DS(0.002)ENS(0.001)NKR 59.56100000000001 0.021753 5092600.0 13496.0 9872.2 12437.0 16391.0 14257.0 10099.0 10380.0 12855.0 8048.7 12013.0 True False 12745.946348768584 10629.365995873819 11636.816960381742 14158.517523947881 12465.908200802865 11490.045580405667 10862.690567579799 12892.405921740183 9658.66489946794 11666.15347647759 1.0925577461729932 0.9111285924110084 0.9974853308629105 1.213640601634089 1.0685534204515497 0.9849043734571975 0.9311287211746521 1.105111976088355 0.8279219812205163 1.0 13.510041338609465 -6.823056670014859 6.027111033578876 0.9730131875369323 1.0539350325520949 0.17025647502567398 0.09583540502771754 0.4358362730842392 30.662437783624576 0.034804174723042466 0.030923235193154368 1.502945837601912e-07 6.823056670014859 0.08092184501516253 TDPPAVNGASLGPS(ph)ISEPDLTSVK ddPTM_A459_Selumetinib_30min_R2 1 TDPPAVNGASLGPSISEPDLTSVK 24 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 T(0.001)DPPAVNGAS(0.028)LGPS(0.475)IS(0.475)EPDLT(0.018)S(0.004)VK 55.40600000000001 0.010099 1973500.0 11425.0 12167.0 14579.0 15962.0 16236.0 12493.0 11480.0 10439.0 10838.0 12919.0 True False 10790.044237898705 13100.169776928831 13641.003012415005 13787.948064014157 14196.288528318395 14213.797349837403 12013.842747188439 10469.375761730518 13005.902839021646 12545.994902406888 0.8600389464392885 1.0441714570133953 1.087279495849153 1.0989920027282178 1.1315394784350588 1.132935049025929 0.9575839015273027 0.8344795166242271 1.036657749360836 1.0 13.614939261125992 -7.3832036287983005 6.930242576843369 0.9412319256401536 1.0645884885260382 0.2371444521074343 0.08781975650853766 0.3333111943968724 17.520729245954573 0.038140577614621606 0.025548674766793893 4.138056072011668e-08 7.3832036287983005 0.12335656288588459 TDPPAVNGASLGPSIS(ph)EPDLTSVK ddPTM_A459_Selumetinib_30min_R1 2 TDPPAVNGASLGPSISEPDLTSVK 24 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 TDPPAVNGASLGPS(0.325)IS(0.675)EPDLTSVK;TDPPAVNGASLGPS(0.024)IS(0.976)EPDLTSVK 159.86 6.2742e-13 19352600.0 5407.1 5651.9 6303.099999999999 6154.5 5437.2 5389.5 5486.2 5325.299999999999 2891.3700000000003 4757.3 True False 5533.074909614908 4990.172920502977 5447.1736404499825 5079.73210927329 4945.406220015624 5335.2865232744725 5072.3715170350415 5184.055744987749 4906.443712690505 5367.945795026134 1.0307620681903644 0.9296243127355727 1.0147594346979547 0.9463083837359351 0.921284679252531 0.9939158715458858 0.9449371716337062 0.9657429383491959 0.9140263147285782 1.0 12.39015438808509 -4.746418914593556 24.753088959218513 0.9587108081917407 1.0307622860412378 0.30204393617519754 0.03274457504211677 892.9964236498283 1471527.1160328574 0.007709804160178937 0.17279295998118657 1.7930032856739552e-05 4.746418914593556 0.07205147784949706 TDPPAVNGASLGPSIS(ph)EPDLTSVK ddPTM_A459_Selumetinib_30min_R2 2 TDPPAVNGASLGPSISEPDLTSVK 24 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 TDPPAVNGASLGPS(0.242)IS(0.741)EPDLT(0.013)S(0.004)VK;TDPPAVNGASLGPS(0.115)IS(0.885)EPDLT(0.001)SVK 133.99 5.2946e-07 2226000.0 37291.0 40646.0 39610.0 43376.0 47313.0 31407.0 40119.0 34201.0 29476.0 37942.0 True False 35218.51550770071 43763.41750251083 37061.53572410718 37468.113972226405 41369.117956413385 35733.029165640226 41984.61299429037 34300.51924771965 35372.02362825261 36846.51587484495 0.9558167080797001 1.1877219993108774 1.00583555443865 1.0168699287469354 1.1227416480008632 0.9697804071085891 1.1394459421047511 0.9309026493638318 0.9599828583087561 1.0 15.169240587262621 -7.78267005543661 24.991810180817165 0.9590820325064593 1.057599484235632 0.25649052947463025 0.07263176507160293 310.86771373022236 365934.3369713222 0.03682902415180779 0.017719602572144395 1.6494150181782667e-08 7.78267005543661 0.0985174517291727 TDQEAPNASQPT(ph)PPPLPK ddPTM_A459_Selumetinib_30min_R1 3 TDQEAPNASQPTPPPLPK 18 0 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 TDQEAPNASQPT(1)PPPLPK;TDQEAPNASQPT(1)PPPLPK;TDQEAPNAS(0.002)QPT(0.998)PPPLPK 165.66 3.7101e-07 17874400.0 6572.700000000001 7657.400000000001 7227.799999999999 8680.3 7859.1 6475.0 7498.5 7047.4 3689.84 6464.0 True False 6725.831121752123 6760.868048171321 6246.304459463498 7164.448554411392 7148.245792636805 6409.867378829611 6932.882107923013 6860.480058818598 6261.3889847490755 7293.717364691936 0.9221403552475331 0.926944068452655 0.8563951887827671 0.9822766904971778 0.9800552222164046 0.87882036804155 0.9505279353823489 0.9406013032571579 0.8584633420345781 1.0 12.832438580242664 -6.360603212221164 0.005777382026705094 1.8505054349042045 6.628383710792696e-08 0.08825335823804181 0.046677007824446455 31832.16812786507 55.59570334138862 8716.06485112704 9090.45974150278 4.3590995554293064e-07 6.360603212221164 -1.8505053686203674 TDQEAPNASQPT(ph)PPPLPK ddPTM_A459_Selumetinib_30min_R2 2 TDQEAPNASQPTPPPLPK 18 0 Q9H792 Q9H792 PEAK1 Pseudopodium-enriched atypical kinase 1 1 TDQEAPNAS(0.001)QPT(0.999)PPPLPK;TDQEAPNAS(0.001)QPT(0.999)PPPLPK 148.19 0.00046938 25785000.0 148617.0 145374.0 142964.0 157312.0 163342.0 112538.0 121195.0 126902.0 104333.0 140526.0 True False 140357.46210098852 156523.71834891514 133765.85188743376 135885.83422166342 142821.51766399242 128039.08798174982 126830.80764333661 127271.26381024292 125202.51530758837 136468.64924960348 1.028496016284827 1.1469573356927611 0.9801947379340858 0.9957293119617966 1.0465518523801716 0.9382307855012484 0.9293768813624066 0.9326044077527404 0.9174452593766854 1.0 17.058210035347578 -5.995278481087216 0.7224356579642934 0.9369580631287587 1.0882171147887412 0.4877215155967183 0.047710144138016 0.7030531328057291 0.7174938112541349 0.026125059729566292 0.06732615535421131 1.0109310107297972e-06 5.995278481087216 0.15125905165998244 TDQGILVTNQDACALASSVSS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 TDQGILVTNQDACALASSVSSPVK 24 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 TDQGILVTNQDACALASSVS(0.245)S(0.754)PVK;TDQGILVTNQDACALASS(0.001)VS(0.262)S(0.737)PVK 214.04 1.7096999999999998e-32 10559200.0 135637.0 136127.0 138769.0 142083.0 133170.0 114657.0 119099.0 127224.0 99917.0 139836.0 True False 128098.83853793162 146567.50318270654 129840.75362026347 122731.05029315404 116439.9940450948 130449.96099738307 124637.33949019121 127594.2007769329 119903.1919142392 135798.57134243925 0.9433003401406084 1.0793007741820169 0.9561275375485937 0.9037727649112506 0.8574463847007014 0.9606136479037858 0.917810388269085 0.9395842645147008 0.8829488464343477 1.0 17.05110877634626 -5.502148994312702 9.252825033254751 0.9200298257292103 1.013014200692497 0.34365684802599916 0.048207806156365676 0.2984837162230605 124.18434600799058 0.012022358649054784 0.023742901005789074 3.146668594750648e-06 5.502148994312702 0.0929843749632866 TDS(ph)CSS(ph)AQAQYDTPK ddPTM_A459_Selumetinib_30min_R2 1 TDSCSSAQAQYDTPK 15 0 Q96PD2;Q96PD2-2 Q96PD2 DCBLD2 Discoidin, CUB and LCCL domain-containing protein 2 2 T(0.092)DS(0.908)CS(0.172)S(0.828)AQAQYDTPK 153.94 0.011835 0.0 31888.0 11518.0 23081.0 22871.0 15360.0 12360.0 30593.0 19820.0 12991.0 15855.0 True False 30115.79261777802 12401.393563792744 21595.99358869269 19755.930345324374 13430.339479857743 14062.47780709119 32015.63511887944 19877.67291862238 15589.562998867894 15397.224953762769 1.95592340231532 0.8054304331484159 1.4025899896601217 1.2830838287191761 0.872257145049741 0.913312486459101 2.0793120328514436 1.2909906154072706 1.0124917344315425 1.0 13.910382736560335 -8.258843161299911 7.223542250750681 1.004339356848071 1.3057669210543672 0.08971798980416779 0.4029155472180774 0.33332211920887206 138.4313494522709 0.31717380809038404 0.10205864756791574 5.51006647963428e-09 8.258843161299911 0.30142756420629624 TDS(ph)CSSAQAQYDTPK ddPTM_A459_Selumetinib_30min_R2 1 TDSCSSAQAQYDTPK 15 0 Q96PD2;Q96PD2-2 Q96PD2 DCBLD2 Discoidin, CUB and LCCL domain-containing protein 2 1 T(0.009)DS(0.729)CS(0.217)S(0.045)AQAQYDTPK 103.67 0.0055022 25023000.0 32224.0 21046.0 37321.0 39226.0 32377.0 27660.0 38725.0 32194.0 22796.0 31082.0 True False 30433.11908289259 22660.160526444015 34919.807492032436 33883.35113137571 28309.511805947554 31469.913927519618 40525.789232131785 32287.679209996404 27355.836973457946 30184.581899265493 1.0082339117519181 0.7507197085607279 1.1568756396417792 1.1225383622822427 0.9378798719301271 1.0425824029149597 1.3425989920078347 1.069674554968147 0.90628510491721 1.0 14.881524197396002 -5.270694754979064 24.985911899981865 1.0803778214055917 0.8794768046591245 0.2596282988300769 0.12967797180162674 762.6346853300538 2058819.9611913369 0.0346137947044311 0.07364226238794 5.3617337597913e-06 5.270694754979064 -0.2009010167464672 TDS(ph)IGEK ddPTM_A459_Selumetinib_30min_R1 1 TDSIGEK 7 0 A0A286YFF8;Q7Z3U7-2;Q7Z3U7-6;Q7Z3U7-5;Q7Z3U7;Q7Z3U7-3 A0A286YFF8 MON2 Protein MON2 homolog 1 T(0.352)DS(0.648)IGEK 122.96 0.007592399999999998 24661000.0 5786.5 8786.4 8086.3 6280.5 4377.7 6967.1 4960.7 8513.1 8120.8 7383.3 True False 5921.31419143102 7757.684203313463 6988.224874866446 5183.728574586223 3981.737807945707 6897.017299620667 4586.510405117519 8287.304933554013 13780.404480234996 8331.018474432234 0.7107551387148451 0.9311807706490718 0.8388199949757883 0.6222202712063363 0.4779413009544509 0.8278720447911027 0.5505341776870917 0.99475291754395 1.6541080208292471 1.0 13.024277161788858 -8.010905439664363 6.246806329224982 1.3310593576693253 0.7171611811862516 0.6169289143585048 0.19527701542952103 0.09447955991774688 15.67572261588745 0.11887334864795875 0.049498459468931014 9.75201948462632e-09 8.010905439664363 -0.6138981764830737 TDS(ph)PDMHEDT ddPTM_A459_Selumetinib_30min_R1 2 TDSPDMHEDT 10 0 Q9BW61 Q9BW61 DDA1 DET1- and DDB1-associated protein 1 1 T(0.045)DS(0.954)PDMHEDT(0.001);T(0.037)DS(0.962)PDMHEDT(0.001) 98.04 0.019987 8838700.0 6357.7 7439.2 8195.9 8571.1 7357.200000000001 7030.6 7299.200000000001 6530.799999999999 4241.8 6165.299999999999 True False 6505.822040069294 6568.215005609744 7082.941796856153 7074.318284473527 6691.742559019157 6959.878547274053 6748.615467380364 6357.581968971885 7198.024791185696 6956.676310107541 0.935191138707548 0.9441599282212698 1.0181502604289863 1.0169106580674252 0.9619166194776873 1.0004603113647619 0.970091918402919 0.9138821019650984 1.034693073289538 1.0 12.764182479211238 -5.113771914745087 7.148115163071275 0.9860675834984249 0.9374396434065062 0.2657495978383676 0.03287000218375088 0.3355935332457944 18.43722124614815 0.008444651581942245 0.022818773681918657 7.695344826907164e-06 5.113771914745087 -0.04862794009191873 TDS(ph)QTIGDFATR ddPTM_A459_Selumetinib_30min_R2 1 TDSQTIGDFATR 12 0 Q13480-2 Q13480-2 GAB1 GRB2-associated-binding protein 1 1 TDS(0.98)QT(0.02)IGDFATR 141.65 0.00097449 3300600.0 26487.0 24220.0 27436.0 29972.0 28056.0 21923.0 15534.0 18891.0 15429.0 23145.0 True False 25014.95857586198 26077.596120425438 25670.797630058165 25889.761895416133 24531.354456177658 24942.694252820416 16256.361780037052 18945.969682426596 18515.231122279478 22476.743712068073 1.112926271541331 1.1602034731758772 1.142104833284866 1.151846647675907 1.0914105161508085 1.109711200712243 0.7232525310732082 0.8429143440495005 0.8237506001520316 1.0 14.456145421748387 -7.208430526960327 8.261000938706875 0.834614393676486 1.130128958024042 0.8117892918454417 0.06606371749489691 0.12869903516373923 18.79222279805387 0.024027533681450167 0.018546052149896793 6.1882731194682e-08 7.208430526960327 0.29551456434755585 TDS(ph)TSDGRPAWMR ddPTM_A459_Selumetinib_30min_R1 4 TDSTSDGRPAWMR 13 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 TDS(0.884)T(0.098)S(0.018)DGRPAWMR;T(0.001)DS(0.456)T(0.456)S(0.087)DGRPAWMR;TDS(0.892)T(0.092)S(0.016)DGRPAWMR;T(0.015)DS(0.895)T(0.04)S(0.05)DGRPAWMR 141.34 0.0039574 580675000.0 10858.9 15004.0 13584.5 16013.9 11981.899999999998 12574.5 12529.5 12446.0 6670.59 9498.9 True False 11111.891242258756 13247.324704829636 11739.799514317203 13217.37298313292 10898.139260576261 12448.0119467325 11584.389727441672 12115.891649694393 11319.504029382662 10718.17634212131 1.0367333851926084 1.2359681611851296 1.0953168841028507 1.2331736819061305 1.0167904420220923 1.1613927173238525 1.0808172358497437 1.130406074966336 1.0561035448631495 1.0 13.38777183702507 -8.779675562852788 0.42092373650737686 0.9897421300559532 1.1432220339105608 0.24459676000127273 0.06949928841711198 2.2705262176271677 0.9035796102932162 0.11133698778560981 0.046159315984458875 1.660827155311839e-09 8.779675562852788 0.15347990385460752 TDS(ph)TSDGRPAWMR ddPTM_A459_Selumetinib_30min_R2 4 TDSTSDGRPAWMR 13 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 T(0.028)DS(0.388)T(0.292)S(0.292)DGRPAWMR;TDS(0.979)T(0.02)S(0.002)DGRPAWMR;TDS(0.425)T(0.288)S(0.288)DGRPAWMR;T(0.002)DS(0.333)T(0.333)S(0.333)DGRPAWMR 115.34 0.019096 199618000.0 384622.0 300976.0 358421.0 357681.0 367720.0 270026.0 291062.0 314699.0 221625.0 352970.0 True False 363246.249003858 324059.89140962687 335360.5830792787 308964.2307658596 321523.7261414904 307219.6304480265 304596.95972841146 315614.7219887761 265956.1927198905 342778.83897380275 1.0597102495922146 0.9453905975636773 0.9783584776798576 0.9013515294317003 0.9379917590714029 0.8962619494475449 0.8886107457516962 0.9207532265808781 0.775882763113672 1.0 18.386918523648404 -1.5228787452807946 0.49371102803933886 0.8922047325132436 5.69494835235134 0.4132009690910091 0.05517096697166905 97.40473831536323 1.0529220168875684 0.029016729345025485 483.62878762405546 0.02999999999996843 1.5228787452807946 4.802743619838097 TDS(ph)YSAGQSVEILDGVELGEPAHK ddPTM_A459_Selumetinib_30min_R1 2 TDSYSAGQSVEILDGVELGEPAHK 24 0 B1AKQ2;B1AKP8;P42345 B1AKQ2 MTOR Serine/threonine-protein kinase mTOR 1 T(0.17)DS(0.793)YS(0.037)AGQSVEILDGVELGEPAHK;T(0.147)DS(0.827)YS(0.026)AGQSVEILDGVELGEPAHK 273.21 9.280099999999997e-74 17241900.0 2587.83 3854.3 2524.07 2606.3 2459.8 2663.8 2349.94 3077.2 1458.74 2927.0299999999997 True False 2648.121403959377 3403.0367641845414 2181.3151577240706 2151.1586313102557 2237.3115243129623 2637.0045905368847 2172.6821338524524 2995.5826598457006 2475.375237845779 3302.742812186606 0.8017946157321792 1.0303668670863098 0.6604556520947855 0.6513248998295647 0.6774101562064209 0.7984286820053772 0.6578417568075825 0.9069984646677506 0.7494907652851533 1.0 11.68944891458545 -11.438173257579162 13.736677717957154 1.0157713574116218 0.7701518252306813 0.25848488530554936 0.11663372333701189 0.050197601301344104 0.0003095364137509132 0.10062721908545474 0.028518688449480547 3.646084608917067e-12 11.438173257579162 -0.24561953218094057 TDSAPDQQVET(ph)GKSPSLSGASAK ddPTM_A459_Selumetinib_30min_R2 1 TDSAPDQQVETGKSPSLSGASAK 23 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 TDSAPDQQVET(0.919)GKS(0.06)PS(0.017)LS(0.003)GASAK 72.316 0.0023549 8318300.0 29688.0 21198.0 26523.0 27523.0 24394.0 20365.0 29017.0 26826.0 19259.0 19948.0 True False 28038.059810480263 22823.81843768697 24816.539056058944 23774.31992017677 21329.407634873052 23170.09389493625 30366.34799609471 26904.059218716615 23111.338141420714 19372.049408871615 1.4473460819091224 1.1781829560704395 1.2810487177827439 1.2272485692344504 1.1010403279843508 1.1960579598937675 1.5675340979766526 1.3888081044432834 1.193024942979789 1.0 14.241688967234246 TDSCSS(ph)AQAQYDTPK ddPTM_A459_Selumetinib_30min_R2 2 TDSCSSAQAQYDTPK 15 0 Q96PD2;Q96PD2-2 Q96PD2 DCBLD2 Discoidin, CUB and LCCL domain-containing protein 2 1 TDSCS(0.226)S(0.774)AQAQYDTPK;T(0.001)DS(0.005)CS(0.281)S(0.713)AQAQYDTPK 276.14 5.365399999999998e-46 18622700.0 142502.0 42066.0 85077.0 95662.0 56302.0 54073.0 160474.0 95825.0 62308.0 62465.0 True False 134582.3093207039 45292.326936491176 79603.23844483386 82632.67057384553 49228.8394137338 61521.06492417818 167936.35897319848 96103.83488531728 74771.34103098004 60661.47314643902 2.218579641081536 0.7466407356635378 1.3122536317683666 1.362193601437394 0.8115338593062779 1.0141703083217921 2.768418738657961 1.58426477137011 1.232600152167081 1.0 15.888492913371337 TDSLAAT(ph)PPAAK ddPTM_A459_Selumetinib_30min_R2 2 TDSLAATPPAAK 12 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 T(0.132)DS(0.004)LAAT(0.864)PPAAK;TDS(0.003)LAAT(0.997)PPAAK 116.71 0.011562 28330000.0 184975.0 160772.0 180856.0 190936.0 182822.0 152651.0 167375.0 163948.0 128625.0 147330.0 True False 174694.83001359412 173102.69543654134 169219.92186112437 164930.1874170282 159854.26591058294 173677.28962219064 175158.26914727042 164425.06153694732 154353.59408277922 143076.2000906883 1.2209915408912486 1.2098636623479018 1.182725860442652 1.1527436940070246 1.1172666439929206 1.2138796635087175 1.2242306479781195 1.1492132264676245 1.0788208939358384 1.0 17.126424182372958 -8.402894492757811 1.9976273051966846 1.0024509508240889 1.1861930621106658 0.7826361236676092 0.032194362893817906 0.1520641264003373 1.255765460307514 0.03371625754685427 0.00956166716497909 3.954626818669253e-09 8.402894492757811 0.18374211128657691 TDSQSVRHS(ph)PIAPSSPSPQVLAQK ddPTM_A459_Selumetinib_30min_R2 1 TDSQSVRHSPIAPSSPSPQVLAQK 24 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.009)DS(0.034)QS(0.129)VRHS(0.827)PIAPSSPSPQVLAQK 77.80199999999998 0.00018714 5814100.0 15065.0 16078.0 20384.0 31147.0 28069.0 18414.0 16817.0 16482.0 14797.0 25687.0 True False 14227.747609973225 17311.13090108176 19072.515632421117 26904.72486842808 24542.7212799562 20950.361354350916 17599.023822253315 16529.959891258008 17756.813462724043 24945.349567158897 0.5703567140507972 0.693962249535771 0.7645719929108752 1.0785467165330385 0.9838595852858777 0.8398503816491925 0.7055031950894294 0.6626469533632058 0.7118286081707702 1.0 14.606483265984302 -5.126072989662433 2.4168014061738 0.8414353022002558 0.5845014374314131 0.3158641238715323 0.13176317283919015 0.4687468123806568 4.915244631254075 0.040299550207340655 0.18080230378878978 7.480437700381249e-06 5.126072989662433 -0.2569338647688426 TDSREDEIS(ph)PPPPNPVVK ddPTM_A459_Selumetinib_30min_R1 6 TDSREDEISPPPPNPVVK 18 1 K7EIE5;K7EID3;K7EJ40;K7EK41;K7EPB2;P10644-2;P10644;K7EMU2;K7EMZ6 K7EIE5 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK 203.17 1.5505000000000002e-10 1831960000.0 34452.1 42088.600000000006 43541.200000000004 47188.7 40475.9 34706.8 37113.7 36222.8 21737.000000000004 31451.3 True False 35254.7668978831 37160.8471455407 37628.544194691625 38948.07938660566 36814.86199160055 34357.68110325305 34314.18372858871 35262.05367576329 36886.101392334254 35488.3807166051 0.9934171744665518 1.047127155287563 1.0603060335487535 1.0974882088204652 1.0373779036464965 0.968138878401319 0.9669131990723099 0.9936225030200966 1.0393853043589323 1.0 15.115059127365608 -6.619016273631428 6.048448538738939 0.9918716788909349 1.0521839374991602 0.44158947000055593 0.03021724067931959 0.19859198817807092 10.423725996058192 0.01065770171013063 0.010644243629834937 2.404272706803864e-07 6.619016273631428 0.06031225860822531 TDSREDEIS(ph)PPPPNPVVK ddPTM_A459_Selumetinib_30min_R2 6 TDSREDEISPPPPNPVVK 18 1 K7EIE5;K7EID3;K7EJ40;K7EK41;K7EPB2;P10644-2;P10644;K7EMU2;K7EMZ6 K7EIE5 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 TDSREDEIS(0.999)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK;TDSREDEIS(1)PPPPNPVVK 150.65 7.6526e-05 1972599400.0 1170316.0 1187064.0 1174351.0 1278781.0 1218678.0 886388.0 960632.0 977281.0 782066.0 1070823.0 True False 1105274.5218661425 1278107.991787641 1098794.5351966922 1104608.821779734 1065576.774520449 1008479.9011708709 1005303.2914561951 980124.7259124207 938501.0527497992 1039905.5576577168 1.0628604816341811 1.2290616031194712 1.0566291593552177 1.062220327264867 1.0246861041117563 0.9697802783575568 0.9667255685415703 0.9425132106419871 0.9024868131906891 1.0 19.98802108068503 -6.17697876886806 0.8927053058551075 0.9446773865021036 1.1457230781050953 0.6847684934111469 0.048374780610433064 0.3273438008195743 0.5497878446618389 0.022545635604524047 0.040843171746446735 6.653056798648279e-07 6.17697876886806 0.20104569160299168 TDSS(ph)PNQAR ddPTM_A459_Selumetinib_30min_R2 2 TDSSPNQAR 9 0 A6NLN1;P26599;P26599-2;P26599-3;K7ES59;A0A087WU68 A6NLN1 PTBP1 Polypyrimidine tract-binding protein 1 1 T(0.009)DS(0.11)S(0.882)PNQAR;TDS(0.142)S(0.858)PNQAR 102.4 0.016165000000000002 15833600.0 9258.5 8326.2 12690.7 9070.9 10338.3 7945.400000000001 13879.5 39187.0 13076.900000000001 17382.6 True False 8743.949634712055 8964.792767047331 11874.194178589418 7835.427771824703 9039.510328425355 9039.806728839998 14524.924251707504 39301.02768224292 15692.64539911442 16880.71917258131 0.517984426215354 0.5310669927859764 0.7034175533158685 0.4641643339788201 0.535493200023603 0.5355107585417925 0.8604446352795069 2.328160742468724 0.9296194811772812 1.0 14.043088748322917 -7.536091189434069 24.87985303776305 1.4961949416990101 0.5622086572946076 0.5369779167486999 0.3596232733399887 144.8858308148258 272825.31295365916 0.15510186816102006 0.0896112141631286 2.9101060147859173e-08 7.536091189434069 -0.9339862844044026 TDSS(ph)PNQAVR ddPTM_A459_Selumetinib_30min_R1 1 TDSSPNQAVR 10 0 A0A0U1RRM4 A0A0U1RRM4 1 TDS(0.051)S(0.949)PNQAVR 94.402 0.025366 0.0 1575.7 1559.2 1706.4 1747.0 2135.1 1690.4 1749.4 1511.1 1012.1 1537.3 True False 1612.4107442215252 1376.6481391475852 1474.6802525842593 1441.9192452515135 1941.9805819825212 1673.396110760399 1617.4413495499803 1471.0207192554385 1717.4597791407052 1734.627429570067 0.9295429766270711 0.7936275627146008 0.8501423576299398 0.8312558770092191 1.1195375726670294 0.9647005934727757 0.9324430837294371 0.8480326634867268 0.9901029753498035 1.0 10.760410112750154 TDSTESSGTQS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 1 TDSTESSGTQSPKR 14 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 TDSTESS(0.002)GT(0.002)QS(0.997)PKR 144.88 0.00094493 1914600.0 1015.0 1286.6 1278.2 1537.1 983.86 1037.4 985.15 1417.0 942.71 1029.1 True False 1038.647525153803 1135.9642738758866 1104.627460650024 1268.6743399405273 894.8700367145912 1026.9646978838366 910.839342351185 1379.4165569353156 1599.7100171857855 1161.19500928287 0.8944643379024253 0.978271750046045 0.9512850570484445 1.0925592426753834 0.7706457826297793 0.8844032997679423 0.7843982578892589 1.1879284236566043 1.3776411407191058 1.0 10.181394561172363 -7.834266436702311 7.634010691739065 1.2164140766500633 0.9135783695524944 0.5219598186972331 0.12218812480574366 0.18266220098533953 16.355851670514536 0.06638462205166235 0.031785853260719324 1.4646490130926065e-08 7.834266436702311 -0.3028357070975689 TDSTESSGTQS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 3 TDSTESSGTQSPKR 14 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 TDSTES(0.002)S(0.007)GT(0.004)QS(0.987)PKR;TDSTESSGTQS(1)PKR;TDS(0.001)T(0.01)ES(0.027)S(0.022)GT(0.241)QS(0.699)PKR 189.33 9.081e-15 5158600.0 22020.9 18619.2 14517.5 16694.1 14577.7 9868.7 15382.0 22649.1 12226.9 20819.1 True False 20797.066534647143 20047.232769835886 13583.45985545888 14420.334781071206 12746.318999708477 11228.023845860915 16097.29347885476 22715.005131239654 14672.621648130065 20217.99848848202 1.028641215226869 0.9915537772572584 0.6718498798581488 0.7132424502497772 0.6304441563278343 0.5553479416994418 0.7961863034080856 1.123504146277395 0.7257207807434006 1.0 14.303352562068998 -11.381622733524106 10.685531952057492 1.0061968428135244 0.7997529590653708 0.09935556298190962 0.17655827716447553 0.028569989542982975 0.00037767674678947934 0.1873815881926778 0.04510630217205301 4.153146649110619e-12 11.381622733524106 -0.2064438837481536 TDSVKT(ph)PESEGNPLLEQLEK ddPTM_A459_Selumetinib_30min_R1 1 TDSVKTPESEGNPLLEQLEK 20 1 Q8WYK2;Q8WYK2-2 Q8WYK2 JDP2 Jun dimerization protein 2 1 T(0.008)DS(0.327)VKT(0.397)PES(0.268)EGNPLLEQLEK 62.792 0.030764 5305800.0 1016.7 1405.9 1317.0 1400.9 1036.4 1209.2 1224.7 1264.1 773.86 1114.9 True False 1040.3871318461793 1241.2965744148214 1138.158633763168 1156.259113149883 942.6578029912815 1197.0365458657564 1132.319892988373 1230.5719616245124 1313.183899501853 1258.008275045643 0.8270113579407354 0.9867157466589676 0.9047306415547015 0.919118845309608 0.7493255980029863 0.9515331255053355 0.9000893837103658 0.9781906733323077 1.0438595083599176 1.0 10.296925696806195 -7.855585034384629 2.3032467831468106 1.0229307464100748 0.8912045458484442 0.4302926743034208 0.0625213366893323 0.30552360695931435 3.154943007100482 0.045249606053122 0.01773189485161414 1.3944885915665769e-08 7.855585034384629 -0.13172620056163054 TDSVKT(ph)PESEGNPLLEQLEK ddPTM_A459_Selumetinib_30min_R2 2 TDSVKTPESEGNPLLEQLEK 20 1 Q8WYK2;Q8WYK2-2 Q8WYK2 JDP2 Jun dimerization protein 2 1 T(0.36)DS(0.076)VKT(0.564)PESEGNPLLEQLEK;T(0.016)DS(0.095)VKT(0.889)PESEGNPLLEQLEK 113.67 0.00041172 10332100.0 57916.0 54001.0 50439.0 50799.0 54502.0 44358.0 56907.0 48449.0 39609.0 58701.0 True False 54697.26057611746 58142.703059417625 47193.80965383092 43880.08856683719 47654.97150593799 50467.91185816759 59553.28825908123 48589.97856883629 47531.90676792839 57006.1496064855 0.9594975446279682 1.0199373832608898 0.8278722555305112 0.7697430692958961 0.8359619415607111 0.8853064486296393 1.0446818224029981 0.8523638046816668 0.833803143977308 1.0 15.798829939672858 -9.545297990460185 16.45701065734363 0.9999787853296129 0.8918637931552481 0.12784477499862035 0.0845211282868741 0.0 0.0 0.0888561161150102 0.02155077366025498 2.8490627168812734e-10 9.545297990460185 -0.10811499217436482 TDT(ph)SPVLETAGTVAAMAATPSAR ddPTM_A459_Selumetinib_30min_R2 1 TDTSPVLETAGTVAAMAATPSAR 23 0 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 1 T(0.002)DT(0.613)S(0.385)PVLETAGTVAAMAATPSAR 252.66 7.8747e-45 4311500.0 8952.3 7721.8 6946.9 10515.0 8720.5 6968.8 8594.7 7829.6 7153.0 8884.3 True False 8454.767004896334 8314.03723049964 6499.944017212825 9082.838860613252 7624.952827740849 7928.6889435321345 8994.370580074963 7852.382839739941 8583.799871518897 8627.787174816427 0.9799461708530409 0.9636349462545172 0.7533732445539982 1.0527425719453385 0.883766911867884 0.918971317080597 1.042488693546887 0.9101270906009589 0.9949016703349006 1.0 13.07477487404596 TDTESELDLISR ddPTM_A459_Selumetinib_30min_R1 1 TDTESELDLISR 12 0 V9GZ78;V9GYY3;A0A384N5Y3;F5H2F4;P11586;A0A494C1T2 V9GZ78 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 138.25 0.017408 2764300.0 1223.2 1240.2 1141.7 1275.3 1116.4 1208.7 1300.1 1313.9 767.94 747.99 False True 1251.698180067126 1094.9968074466624 986.663410909194 1052.592795345881 1015.4218171164289 1196.5415754117914 1202.0324102834854 1279.051103851314 1303.1380918815462 844.001802539591 1.4830515483507045 1.2973868114402487 1.1690299806710553 1.2471451982432293 1.2031038489029728 1.4177002606053832 1.4242059752320253 1.5154601566047194 1.5439991809975047 1.0 9.72110226988272 -6.779617804226647 24.57562653214678 1.4152352446539216 1.272928573529847 0.06740371399491363 0.16131246622181744 381.5880988565799 515869.6421979894 0.05510254634152565 0.048695026405621386 1.6610480502987646e-07 6.779617804226647 -0.14230667112407458 TDTESELDLISR ddPTM_A459_Selumetinib_30min_R2 1 TDTESELDLISR 12 0 V9GZ78;V9GYY3;A0A384N5Y3;F5H2F4;P11586;A0A494C1T2 V9GZ78 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 166.29 0.0065987 2611100.0 11607.0 9170.8 12069.0 14094.0 14404.0 11527.0 11542.0 11364.0 7344.4 15225.0 False True 10961.929406502433 9874.170871230293 11292.493679733641 12174.37288649389 12594.44074660618 13114.73961831232 12078.725870039112 11397.067358588523 8813.48521968173 14785.414690699352 0.7414015525312218 0.6678318517127262 0.7637590095350586 0.823404222416033 0.851815184766418 0.8870051934736767 0.8169352109979803 0.7708317688077939 0.596093204286369 1.0 13.85188708725019 -5.522910208793463 3.965417089883698 0.814711665036117 0.7051628827222706 0.18706411007523616 0.09672212087297276 0.36950723588769796 13.210853101533358 0.026597143871840194 0.05328399105710542 2.999782665623865e-06 5.522910208793463 -0.10954878231384646 TDTGIVTVEQS(ph)PSSSK ddPTM_A459_Selumetinib_30min_R2 2 TDTGIVTVEQSPSSSK 16 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 TDTGIVTVEQS(0.487)PS(0.487)S(0.018)S(0.007)K;TDTGIVTVEQS(0.855)PS(0.094)S(0.026)S(0.026)K 196.65 1.1536e-06 46430000.0 286844.0 292073.0 313930.0 324250.0 325380.0 276185.0 275662.0 263902.0 226617.0 320360.0 True False 270902.3588075115 314474.05993728334 293732.08558114024 280086.5906375516 284502.855465893 314226.9767921912 288480.8292138903 264669.91112867196 271946.7322080245 311110.3744047582 0.8707596438268059 1.0108118719568924 0.9441410822224506 0.9002804588996306 0.9144756294618175 1.010017674252734 0.9272620039297481 0.8507267288500425 0.8741165662775958 1.0 18.247066978768267 -7.534148091047261 24.751218806163575 0.895251846564093 0.9441019934943079 0.05322365951380259 0.05511224619418542 401.40062154458997 881595.1625767506 0.02511432426836979 0.014515816390049986 2.9231554345648788e-08 7.534148091047261 0.048850146930214944 TDTGIVTVEQSPS(ph)SSK ddPTM_A459_Selumetinib_30min_R1 1 TDTGIVTVEQSPSSSK 16 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.263)DTGIVT(0.001)VEQS(0.135)PS(0.3)S(0.092)S(0.209)K 152.68 0.00016493 21786000.0 3594.9 4350.9 4591.8 4964.7 4212.7 3739.0 4211.8 4249.3 2448.1 3790.4 True False 3678.6541755422754 3841.4946053214658 3968.258780951946 4097.708343961184 3831.662028812592 3701.389054740372 3894.1005350603677 4136.594760328326 4154.24689785037 4276.934761622571 0.8601146336276305 0.8981887308152651 0.927827755653322 0.9580946571199527 0.8958897533800462 0.8654303282699943 0.9104886448123036 0.9671867799917051 0.9713140670573015 1.0 12.062361485843738 -7.800130639280112 3.464626397628875 0.9810854158544988 0.903028022069065 0.6316352144344846 0.027268954189222108 0.1781687622951238 4.371745544987001 0.017847371663288602 0.008218278716879598 1.5844165155139824e-08 7.800130639280112 -0.07805739378543386 TDTGIVTVEQSPS(ph)SSK ddPTM_A459_Selumetinib_30min_R2 1 TDTGIVTVEQSPSSSK 16 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.003)DT(0.002)GIVT(0.019)VEQS(0.116)PS(0.764)S(0.062)S(0.034)K 118.5 0.0017574 2752200.0 19136.0 22454.0 20412.0 26380.0 27433.0 21373.0 16329.0 22388.0 15467.0 23026.0 True False 18072.497727477432 24176.149599010452 19098.714142905228 22786.998491961745 23986.62128586835 24316.936745223302 17088.330855299664 22453.14537346708 18560.832184088194 22361.1795512672 0.8082086048297604 1.081166113960227 0.8541013723859174 1.0190427763311087 1.0726903395625673 1.0874621658250256 0.7641963079864128 1.0041127446782954 0.8300470975394658 1.0 14.448708671839663 -10.479985589802444 5.991252723819946 1.0000000258093062 0.9542898350007565 0.01463321454469313 0.11725001737909285 3.917753903599243e-08 6.839312954098707e-09 0.1099941907432712 0.026677494696305384 3.311421088292895e-11 10.479985589802444 -0.04571019080854977 TDTPPSSVPTSVISTPSTEEIQSETPGDAQGS(ph)PPELKRPR ddPTM_A459_Selumetinib_30min_R1 1 TDTPPSSVPTSVISTPSTEEIQSETPGDAQGSPPELKRPR 40 2 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TDTPPSSVPT(0.001)S(0.001)VIS(0.029)T(0.029)PS(0.073)T(0.073)EEIQS(0.073)ET(0.073)PGDAQGS(0.646)PPELKRPR 53.372 0.00022234 7639600.0 457.56 266.38 1329.1 1472.6 806.41 673.77 240.57 624.85 330.41 275.33 True False 468.22025774322606 235.19210576329763 1148.6155202237107 1215.4380541255734 733.4703578832491 666.9924855342128 222.4236112159818 608.2769482011524 560.6816378083989 310.67128744131037 1.507124335819668 0.7570448743440068 3.6972052669678988 3.9122960610100947 2.3609209718867588 2.1469395869427292 0.7159451813132244 1.9579438872865373 1.8047423771478033 1.0 8.279245102041774 -7.042807669950271 6.4433537708962 1.4423224968859198 2.4822385477871465 0.23097412813499574 0.9265678150684215 0.38307811333475855 42.905908532109706 0.39162113640345975 0.3084070170392759 9.061337991215756e-08 7.042807669950271 1.0399160509012266 TDTS(ph)PVLETAGTVAAMAATPSAR ddPTM_A459_Selumetinib_30min_R1 3 TDTSPVLETAGTVAAMAATPSAR 23 0 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 1 T(0.003)DT(0.051)S(0.946)PVLETAGTVAAMAATPSAR;T(0.038)DT(0.038)S(0.925)PVLETAGTVAAMAATPSAR;TDT(0.037)S(0.963)PVLETAGTVAAMAATPSAR 198.88 8.1318e-23 24748200.0 3175.5299999999997 3106.2400000000002 3042.69 3381.67 3061.09 2962.69 2835.47 2602.51 1620.3600000000001 2448.48 True False 3249.513670494241 2742.5599767482013 2629.509410299813 2791.124816307777 2784.2149499793327 2932.888028507291 2621.588215050006 2533.482980656127 2749.632573588019 2762.7662582148687 1.1761811774094415 0.9926862138964577 0.9517668758553762 1.0102645520621176 1.007763484044547 1.0615766063403222 0.9488997512022305 0.9170095273615761 0.9952461832093839 1.0 11.431897793834244 -4.762175626790039 6.232381463853369 0.9856244009920719 1.1823134332512768 0.6911280422421916 0.03790665716034147 0.07666721523450758 12.61311518677941 0.01016708536055002 0.06432265943928987 1.7291169704654352e-05 4.762175626790039 0.19668903225920487 TDTS(ph)PVLETAGTVAAMAATPSAR ddPTM_A459_Selumetinib_30min_R2 1 TDTSPVLETAGTVAAMAATPSAR 23 0 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 1 T(0.044)DT(0.058)S(0.899)PVLETAGTVAAMAATPSAR 115.38 1.0858e-05 4900900.0 12099.0 12915.0 14976.0 14540.0 14321.0 10674.0 13392.0 10428.0 10401.0 11420.0 True False 11426.586016134483 13905.538971729758 14012.46046463593 12559.626917100968 12521.867948635603 12144.246611075356 14014.754535744565 10458.343753551668 12481.49062822145 11090.27492727662 1.030324864898588 1.2538497974950085 1.263490811230673 1.1324901320715202 1.1290854402389943 1.0950356677999464 1.263697665535339 0.9430193410110409 1.1254446539934844 1.0 13.437007509819338 -7.764530504625068 24.99977593841354 1.0256740102128745 1.1683798055933778 0.3828772757520591 0.08375711803269173 86.34853026446652 698325.5697684085 0.04272431261978133 0.021903160579381242 1.719766541462532e-08 7.764530504625068 0.14270579538050332 TDVKDDLSDPPVASSCIS(ph)EKSPR ddPTM_A459_Selumetinib_30min_R2 1 TDVKDDLSDPPVASSCISEKSPR 23 2 Q8IX90;Q8IX90-3 Q8IX90 SKA3 Spindle and kinetochore-associated protein 3 1 TDVKDDLSDPPVAS(0.111)S(0.026)CIS(0.751)EKS(0.112)PR 50.956 0.016047 6734200.0 92126.0 88378.0 90030.0 89793.0 85791.0 84465.0 95880.0 85968.0 73866.0 91619.0 True False 87006.005729598 95156.30841994044 84237.56781725261 77563.03849843524 75013.16759872895 96099.28705307106 100338.60998261564 86218.15264723139 88641.26398848245 88973.72141525023 0.9778843050020501 1.0694877870268615 0.9467690738044612 0.871752212503734 0.8430935157655616 1.0800861819026881 1.12773309227254 0.9690294086367558 0.9962634200134648 1.0 16.44109167538081 -6.788381559255388 24.9949396358734 1.0385061761340542 0.9452759994410292 0.299244694140992 0.07079949659772308 324.27399093309896 300834.9224863236 0.027978570505097815 0.024681390574350343 1.6278652063353752e-07 6.788381559255388 -0.09323017669302491 TDVSNFDEEFTGEAPT(ph)LSPPRDAR ddPTM_A459_Selumetinib_30min_R1 3 TDVSNFDEEFTGEAPTLSPPRDAR 24 1 Q16512;Q16512-2 Q16512 PKN1 Serine/threonine-protein kinase N1 1 TDVSNFDEEFTGEAPT(0.5)LS(0.5)PPRDAR;TDVSNFDEEFT(0.002)GEAPT(0.632)LS(0.366)PPRDAR;TDVSNFDEEFTGEAPT(0.657)LS(0.343)PPRDAR 140.12 6.2653e-08 96292000.0 3886.71 2866.6499999999996 5512.9 5948.9 4926.200000000001 4238.5 3800.2000000000003 3021.1 2247.12 2856.52 True False 3977.2627807788544 2531.021285330569 4764.2784601920785 4910.036289683298 4480.626079791252 4195.864538250087 3513.547854441426 2940.970614084182 3813.198516848791 3223.1821668610473 1.2339553195816362 0.7852554259430669 1.4781288222476903 1.5233505385347248 1.390124990718346 1.301777039284225 1.0900866511876852 0.912443188697677 1.1830539880910118 1.0 11.654270013177499 -7.34549137026664 4.301282791579009 1.0311353282282172 1.2871163770317202 0.2591379070023583 0.19920049069723525 0.3592481249174101 12.126075348861335 0.09503083165757446 0.06279333413096296 4.513449937907392e-08 7.34549137026664 0.25598104880350303 TDVSNFDEEFTGEAPTLS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 TDVSNFDEEFTGEAPTLSPPR 21 0 Q16512;Q16512-2 Q16512 PKN1 Serine/threonine-protein kinase N1 1 TDVSNFDEEFTGEAPT(0.074)LS(0.926)PPR;TDVSNFDEEFTGEAPT(0.257)LS(0.743)PPR;TDVSNFDEEFTGEAPT(0.151)LS(0.849)PPR;TDVSNFDEEFTGEAPT(0.258)LS(0.742)PPR 154.34 3.1947e-07 44016000.0 2730.3999999999996 3179.67 2919.9300000000003 2433.4300000000003 2902.58 2217.66 2930.51 2810.2200000000003 1525.0500000000002 2102.6800000000003 True False 2794.013007566447 2807.3927582115193 2523.419544027402 2008.4771316384597 2640.0421514921213 2195.352353874173 2709.4592713328625 2735.6838367189603 2587.8984647549973 2372.5794598376283 1.1776267370019549 1.183266063680602 1.0635764098708402 0.8465373512826051 1.1127307625232485 0.9253019302562856 1.1419888426068938 1.1530420300048376 1.0907531269498998 1.0 11.212240689882776 -5.295478377747624 5.351670750052815 1.0414928731883693 1.1813322481174284 0.27089945595216836 0.09139217540499488 0.2418791586622408 19.59274334517314 0.025057831643189362 0.056379238712450645 5.064325626926869e-06 5.295478377747624 0.13983937492905918 TDVSNFDEEFTGEAPTLS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 TDVSNFDEEFTGEAPTLSPPR 21 0 Q16512;Q16512-2 Q16512 PKN1 Serine/threonine-protein kinase N1 1 TDVSNFDEEFTGEAPT(0.084)LS(0.916)PPR;TDVSNFDEEFTGEAPT(0.025)LS(0.975)PPR 121.26 4.8523e-05 8596800.0 63365.0 52383.0 63037.0 66605.0 70565.0 49638.0 57885.0 61371.0 51206.0 66544.0 True False 59843.42697019275 56400.607662107606 58981.2680494962 57533.28409996636 61699.99384089595 56475.18393109974 60576.76719695149 61549.57944948403 61448.630815182 64622.70181792425 0.9260434071420102 0.8727677128235437 0.9127019822798046 0.8902952442636572 0.9547727362860332 0.8739217386827882 0.9373914350970305 0.9524451580947698 0.9508830347006341 1.0 15.979753449215488 -8.247866656826483 0.5740018689755485 1.0006368453349064 0.9005249605276138 0.6004702604795389 0.024264968396110843 0.5191037010910785 0.4122542250450617 0.023758057894420506 0.01165377009756616 5.651104563044523e-09 8.247866656826483 -0.1001118848072926 TDVSNFDEEFTGEAPTLS(ph)PPRDAR ddPTM_A459_Selumetinib_30min_R1 1 TDVSNFDEEFTGEAPTLSPPRDAR 24 1 Q16512;Q16512-2 Q16512 PKN1 Serine/threonine-protein kinase N1 1 TDVSNFDEEFTGEAPT(0.474)LS(0.526)PPRDAR 105.25 3.5036e-07 17389000.0 1129.7 1195.3 1769.7 1859.1 1632.5 1502.2 1180.7 1129.5 612.48 943.5 True False 1156.0198119864542 1055.3537203201063 1529.3844602662707 1534.4430846291284 1484.8406632412846 1487.0892318884705 1091.638848412977 1099.5419908669298 1039.3338262307068 1064.6074154682615 1.0858648880235213 0.9913078802442072 1.4365713013501598 1.441322934947069 1.3947307163816682 1.3968428270193691 1.0253909869046196 1.0328145144314091 0.976260179226313 1.0 10.056105805091315 -7.278895724967148 21.399414860812527 1.01135063310585 1.2956297048438559 0.4892396116821526 0.14134611042292786 128.8401138742787 157939.90178246214 0.06725783052602358 0.04555015940669776 5.2614357942346106e-08 7.278895724967148 0.28427907173800593 TDYNAS(ph)VSVPDSSGPER ddPTM_A459_Selumetinib_30min_R1 3 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 TDYNAS(0.966)VS(0.006)VPDS(0.022)S(0.005)GPER;T(0.009)DYNAS(0.964)VS(0.027)VPDSSGPER;T(0.357)DYNAS(0.639)VS(0.004)VPDSSGPER 258.17 4.3611000000000006e-40 12774800.0 2420.9 2771.44 3453.93 3612.4 3781.27 2672.45 3834.9999999999995 3436.29 1285.4 2142.16 True False 2477.3022597486142 2446.9585163925003 2984.9052770794387 2981.562153146289 3439.2547961374416 2645.567579390455 3545.722862423785 3345.148426556991 2181.2299180984714 2417.1271024053945 1.0248953219230121 1.0123416819733722 1.2348979390074366 1.2335148408948786 1.4228688233708855 1.0945090875683487 1.4669161828086215 1.3839356743913382 0.902405966127238 1.0 11.239077622551967 -5.269791513954287 7.288979677603777 1.243785572471238 1.0179190804907772 0.1611784404331631 0.17320668441795792 0.1895978428484921 73.54795393199409 0.0436468322678833 0.09967491551411552 5.372896640592765e-06 5.269791513954287 -0.22586649198046094 TDYNAS(ph)VSVPDSSGPER ddPTM_A459_Selumetinib_30min_R2 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 TDYNAS(0.987)VS(0.006)VPDS(0.007)SGPER 203.89 2.2821e-08 5533300.0 20170.0 18810.0 20533.0 22303.0 24774.0 15350.0 16904.0 16073.0 12519.0 22677.0 True False 19049.032146907397 20252.666516317197 19211.929134640057 19265.29292517903 21661.668637629933 17464.32316657361 17690.069494640553 16119.769768971608 15023.149810085986 22022.256088078106 0.8649900387462898 0.9196454003312182 0.8723869642511587 0.8748101397117266 0.9836262257142955 0.7930306094309764 0.8032814360113263 0.7319763108966003 0.6821803247587729 1.0 14.426674654099036 -6.871844107393596 8.943599028206693 0.7844271689944778 0.9006000996930374 0.2549802845742213 0.08368584543589565 0.3248759675589158 24.489518107158617 0.0282762300913875 0.02494604666394941 1.3432470411835786e-07 6.871844107393596 0.1161729306985596 TDYNASVSVPDS(ph)SGPER ddPTM_A459_Selumetinib_30min_R2 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 TDYNAS(0.201)VS(0.113)VPDS(0.444)S(0.242)GPER 114.21 0.001737 7956100.0 10794.0 10894.0 13318.0 12849.0 15353.0 10184.0 7859.6 12753.0 9337.3 11630.0 True False 10194.112691805574 11729.534770268989 12461.134379542025 11098.944034238679 13424.218882438547 11586.753558852482 8225.086973501939 12790.109118627202 11205.020905960211 11294.211681631099 0.9025962129242959 1.0385439108907353 1.1033204203006757 0.9827108210031158 1.188592817351891 1.025901929720086 0.728256845661855 1.132448149473684 0.9921029658213377 1.0 13.463295955929715 -7.01789589732028 24.977257463450687 0.9603593565602646 1.049318134808886 0.09602673631432623 0.1159563668386478 1737.1795161027303 2424573.1304980367 0.04368565013213921 0.034536530542887814 9.59630632476591e-08 7.01789589732028 0.08895877824862142 TDYNASVSVPDSSGPER ddPTM_A459_Selumetinib_30min_R1 2 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ; 309.29 6.645199999999996e-102 22110000.0 2311.71 2509.92 2577.44 2556.1499999999996 2695.5 2313.7200000000003 2404.63 2149.98 1883.4 2427.26 False True 2365.5683451953682 2216.0573995698473 2227.437804864496 2109.7663873781644 2451.6925009291767 2290.4460774896775 2223.2468231212797 2092.955546280727 3195.992241906537 2738.8224645145647 0.8637173003525247 0.8091278015578226 0.8132830198832519 0.7703187828759482 0.8951629879973694 0.836288626650958 0.8117528068820383 0.7641808015663722 1.1669220197056482 1.0 11.41934003560292 -8.257890141928337 24.999892251345337 1.0834610216178642 0.8209143434564126 0.8005261173682874 0.05250954507106822 111.77006554479948 787293.4609687402 0.03690940874701877 0.012695058308181843 5.522171091062349e-09 8.257890141928337 -0.2625466781614516 TDYNASVSVPDSSGPER ddPTM_A459_Selumetinib_30min_R2 4 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 ;;; 293.41 6.925399999999996e-75 22676100.0 32986.200000000004 33382.8 37790.9 41399.8 41644.7 30021.899999999998 30012.0 29582.4 31290.799999999996 32875.799999999996 False True 31152.959058220975 35943.153417379785 35359.47463762083 35761.07582136153 36412.92047765834 34157.14421332613 31407.617467649805 29668.479886370027 37549.83433800133 31926.590232413375 0.9757684372630882 1.1258062059157388 1.107524304356255 1.1201031980250495 1.1405201812215522 1.0698650862705719 0.9837448107992226 0.9292717972822914 1.1761304312378142 1.0 14.962470860504206 -7.04914345376525 6.126314640012276 1.0172212729297558 1.0986881149216916 0.17615544181223552 0.07249098595920189 0.33854015366214574 30.62998633777939 0.027117975874996574 0.021288038013351728 8.930104607057135e-08 7.04914345376525 0.08146684199193577 TEAELSQDLET(ph)SPTAKPQIK ddPTM_A459_Selumetinib_30min_R2 1 TEAELSQDLETSPTAKPQIK 20 1 Q5VT06;H0Y7F7 Q5VT06 CEP350 Centrosome-associated protein 350 1 TEAELS(0.005)QDLET(0.495)S(0.495)PT(0.005)AKPQIK 94.384 0.0015468 7890700.0 31307.0 29278.0 31108.0 36785.0 34636.0 30751.0 31438.0 33799.0 22538.0 29725.0 True False 29567.08227185077 31523.528456392087 29106.545147829478 31774.81954233558 30284.71603023132 34986.67112021532 32899.92929321521 33897.34949427433 27046.229764335654 28866.7620151749 1.0242604368410881 1.0920354849574248 1.0083065475971476 1.100740690127696 1.04912064658693 1.212005388821346 1.1397166497551794 1.1742691984800688 0.9369332712175265 1.0 14.817121669089513 TEAELSQDLETS(ph)PTAKPQIK ddPTM_A459_Selumetinib_30min_R2 1 TEAELSQDLETSPTAKPQIK 20 1 Q5VT06;H0Y7F7 Q5VT06 CEP350 Centrosome-associated protein 350 1 TEAELSQDLET(0.171)S(0.828)PT(0.001)AKPQIK 88.555 0.0010798 3174400.0 18292.0 17347.0 17960.0 20320.0 20904.0 12258.0 17392.0 16495.0 14061.0 19611.0 True False 17275.40386867775 18677.45912060363 16804.47315336948 17552.380946044836 18277.852635868905 13946.428232955011 18200.762461594197 16542.997719105748 16873.59289716584 19044.779474502786 0.9070939304813751 0.9807128061319416 0.8823663816043322 0.9216373951477895 0.9597303376675669 0.7322966512490489 0.9556825000762775 0.868636874543681 0.8859957092050481 1.0 14.217107962127352 -5.280687740845285 24.513201149778382 0.8948936167072719 0.9439033775550261 0.05140436007942861 0.07052292932363186 1522.6991181240867 1939188.7368904466 0.017763739260785876 0.03707977607312651 5.239770423885193e-06 5.280687740845285 0.049009760847754213 TEAELSQDLETSPT(ph)AKPQIK ddPTM_A459_Selumetinib_30min_R2 1 TEAELSQDLETSPTAKPQIK 20 1 Q5VT06;H0Y7F7 Q5VT06 CEP350 Centrosome-associated protein 350 1 TEAELS(0.003)QDLET(0.175)S(0.126)PT(0.695)AKPQIK 85.49600000000002 0.0033329 5644700.0 30095.0 27458.0 26893.0 34014.0 29856.0 19583.0 25611.0 30219.0 19500.0 24531.0 True False 28422.44037983033 29563.94030861444 25162.733658884477 29381.234522577193 26105.222363973513 22280.38049322547 26801.962247233725 30306.932286975236 23400.544875523352 23822.726290807586 1.1930809275510008 1.240997354699164 1.056249119085667 1.2333279643948416 1.0958117070776516 0.9352573765590694 1.1250585646688023 1.2721857237082765 0.9822782073667555 1.0 14.54005090531067 -1.5228787452803376 0.20538457767221469 1.0422486093568784 1.8967013598775238 0.21600515997296388 0.10006766093965332 96.37518133273649 1.1837571202517492 0.18274540199573727 26.713538486312242 0.029999999999999995 1.5228787452803376 0.8544527505206454 TEAFT(ph)SPEALQPGGTALAPK ddPTM_A459_Selumetinib_30min_R2 1 TEAFTSPEALQPGGTALAPK 20 0 Q7Z5J4-3;Q7Z5J4 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 T(0.011)EAFT(0.872)S(0.117)PEALQPGGTALAPK 176.68 1.5212999999999998e-11 0.0 10768.0 10705.0 10947.0 12934.0 12650.0 8336.7 8994.9 11496.0 8870.1 10960.0 True False 10169.557667719324 11526.039077999763 10242.681938192412 11172.366887605507 11060.793907565145 9485.004751972268 9413.18067305622 11529.451456734745 10644.367851301522 10643.556322500152 0.9554661392847794 1.0829123958910303 0.9623364247661937 1.0496836347816816 1.0392009561863234 0.8911499563281551 0.8844018284712831 1.0832330010188267 1.0000762460193549 1.0 13.377692657417022 -4.471146636590887 18.272865654979906 0.9978638101624041 0.5817853675823903 0.036973250110609035 0.06666958518284792 20797396.24112052 158251210.97109073 0.017328081653045144 319954612.5618179 3.379507101713483e-05 4.471146636590887 -0.4160784425800138 TEAPAPASSTPQEPWPGPT(ph)APSPTSRPPWAVDPAFAER ddPTM_A459_Selumetinib_30min_R2 1 TEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAER 38 1 Q9NR12-2;Q9NR12 Q9NR12-2 PDLIM7 PDZ and LIM domain protein 7 1 TEAPAPASST(0.001)PQEPWPGPT(0.586)APS(0.258)PT(0.077)S(0.077)RPPWAVDPAFAER 82.042 2.4335e-07 2862000.0 12070.0 14973.0 15051.0 14558.0 15789.0 10339.0 10385.0 10260.0 11601.0 13274.0 True False 11399.197720038288 16121.380954216771 14082.635046289748 12575.175286049247 13805.44466454909 11763.103401902576 10867.923077487114 10289.854901365568 13921.524159022894 12890.745130006111 0.8842931580040388 1.2506166859734607 1.0924609015431734 0.9755196584236 1.0709578480776731 0.912523153880477 0.843079509204598 0.7982358504174918 1.0799627188825116 1.0 13.654048038461953 -6.764155151932642 23.25612919002799 0.9089198752871612 1.06334124771874 0.23094023172028455 0.11397326131690909 37.585333636426355 321850.5939251048 0.03870399448866183 0.035714913637461515 1.7212535463959214e-07 6.764155151932642 0.15442137243157883 TEAPAPASSTPQEPWPGPTAPS(ph)PTSRPPWAVDPAFAER ddPTM_A459_Selumetinib_30min_R1 2 TEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAER 38 1 Q9NR12-2;Q9NR12 Q9NR12-2 PDLIM7 PDZ and LIM domain protein 7 1 TEAPAPASSTPQEPWPGPT(0.087)APS(0.881)PT(0.031)S(0.001)RPPWAVDPAFAER;TEAPAPASSTPQEPWPGPT(0.383)APS(0.479)PT(0.069)S(0.069)RPPWAVDPAFAER 115.77 1.846e-23 13511300.0 2185.1 2470.3 2440.0 2869.8 2304.6000000000004 2093.3 2107.4 2094.31 1284.4299999999998 1989.7 True False 2236.0085785355427 2181.0761275886857 2108.661401960615 2368.643302817854 2096.1493369101763 2072.2433025643286 1948.4371213225259 2038.7620955223736 2179.5838989444665 2245.0973763192364 0.9959517133289806 0.971483976861836 0.939229373390341 1.0550292062169557 0.9336563122027003 0.9230082064243038 0.8678630788464617 0.9080951753036464 0.9708193158720905 1.0 11.132562304811678 -6.492033583510455 24.772165793936743 0.924554437987826 0.9865301156819142 0.2784276781163435 0.043086330240035504 728.5124570576295 585078.621141731 0.01326378823230015 0.015021042151886092 3.220819719237793e-07 6.492033583510455 0.06197567769408818 TEAPGT(ph)PEGPEPERPSPGDGNPR ddPTM_A459_Selumetinib_30min_R1 1 TEAPGTPEGPEPERPSPGDGNPR 23 1 A0A0G2JNW7;Q9Y666-2;Q9Y666 A0A0G2JNW7 SLC12A7 Solute carrier family 12 member 7 1 T(0.288)EAPGT(0.546)PEGPEPERPS(0.166)PGDGNPR 77.062 0.0011064999999999998 11294000.0 1503.0 1204.9 1414.2 867.24 1614.7 1187.7 1633.9 1751.1 553.04 1244.8 True False 1538.016975671099 1063.8297478571874 1222.1594076445506 715.7928141110032 1468.6506700984387 1175.7528163453171 1510.6536075395632 1704.65513962557 938.4684875565408 1404.5822053787927 1.094999616100306 0.7573994201146027 0.8701230892462819 0.5096126174530067 1.045613894633079 0.8370836622041897 1.0755181161733178 1.213638570314831 0.6681477837058681 1.0 10.455925347589698 TEAPGT(ph)PEGPEPERPSPGDGNPR ddPTM_A459_Selumetinib_30min_R2 2 TEAPGTPEGPEPERPSPGDGNPR 23 1 A0A0G2JNW7;Q9Y666-2;Q9Y666 A0A0G2JNW7 SLC12A7 Solute carrier family 12 member 7 1 T(0.032)EAPGT(0.95)PEGPEPERPS(0.018)PGDGNPR;T(0.197)EAPGT(0.802)PEGPEPERPSPGDGNPR 69.649 0.0037812 24298000.0 47179.0 21659.5 39780.0 41000.0 30352.0 26399.0 56100.0 46288.0 36666.0 30150.0 True False 44556.98005250096 23320.71400373059 37220.59810918916 35415.72927105502 26538.910409677253 30035.222623737907 58708.761160041075 46422.690416609104 44000.224533637906 29279.491160892296 1.5217812293136546 0.7964863144506876 1.2712173823192512 1.2095746157760658 0.9063993039989865 1.0258109493328564 2.005115486380328 1.5855019529374352 1.5027660245819994 1.0 14.837602861243942 -7.2271653446974895 24.993116219211196 1.5721378794902936 1.108067535876956 0.30127209443035696 0.2953645628369835 645.5794565444277 470766.44599283685 0.10753458753339576 0.08329160471982788 5.9269962887689267e-08 7.2271653446974895 -0.46407034361333754 TEAQDLCRAS(ph)PEPPGPESSSR ddPTM_A459_Selumetinib_30min_R1 3 TEAQDLCRASPEPPGPESSSR 21 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 TEAQDLCRAS(1)PEPPGPESSSR;TEAQDLCRAS(1)PEPPGPESSSR;T(0.001)EAQDLCRAS(0.997)PEPPGPES(0.002)SSR 140.93 9.7501e-06 327532000.0 7619.6 7350.0 18148.4 20641.300000000003 12407.099999999999 11508.3 8567.699999999999 7256.7 4684.75 4582.7699999999995 True False 7797.12185483933 6489.4585830777005 15683.946962025424 17036.68444018893 11284.879995651416 11392.536950700358 7921.43149110516 7064.228742916382 7949.6785893977085 5171.0131694599695 1.5078518656438882 1.2549684888455663 3.033051057509367 3.2946511412517134 2.182334414133767 2.2031537297148533 1.5318915716341963 1.3661208183799942 1.5373541565023565 1.0 12.33623126372249 -7.307277943711606 2.509860222208244 1.3390801464793645 2.297686029437351 0.35959508508056104 0.5843258160704604 0.3858222933741609 4.7780690179592895 0.31630845326992474 0.20302273299715293 4.928582790991156e-08 7.307277943711606 0.9586058829579864 TEAQDLCRAS(ph)PEPPGPESSSR ddPTM_A459_Selumetinib_30min_R2 2 TEAQDLCRASPEPPGPESSSR 21 1 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 TEAQDLCRAS(1)PEPPGPESSSR;T(0.005)EAQDLCRAS(0.986)PEPPGPES(0.004)S(0.003)S(0.001)R 118.05 4.1504e-05 249700000.0 148938.0 243120.0 218470.0 235090.0 230990.0 128953.0 57975.0 74443.0 68625.0 239790.0 True False 140660.62220605335 261766.52224598787 204413.8780521513 203070.33644712972 201970.97112319947 146715.10523121612 60670.952375283094 74659.616805298 82351.91754270707 232866.63965075824 0.6040393867365851 1.1241048637905895 0.8778152094208128 0.8720456341521674 0.8673246259150965 0.6300391737144149 0.26053947644142744 0.32061104552059827 0.3536441186518359 1.0 17.82914444907489 -6.924452088313117 3.3022558180417674 0.4270436532091855 0.8848570768448499 0.38253688531608077 0.22630158088415145 0.21057049566621105 4.62190364625159 0.08151333585999088 0.06967440296157709 1.1900026038818432e-07 6.924452088313117 0.4578134236356644 TEARSS(ph)DEENGPPS(ph)SPDLDR ddPTM_A459_Selumetinib_30min_R2 1 TEARSSDEENGPPSSPDLDR 20 1 Q96B36-3;Q96B36;Q96B36-2 Q96B36-3 AKT1S1 Proline-rich AKT1 substrate 1 2 T(0.028)EARS(0.188)S(0.784)DEENGPPS(0.631)S(0.369)PDLDR 99.423 0.0016166 4799500.0 8284.3 12953.0 12959.0 13913.0 14805.0 8622.3 7394.6 7997.0 7845.2 11915.0 True False 7823.891770680466 13946.453449540502 12125.232048692373 12018.025398736305 12945.06354162071 9809.943559553587 7738.463552121927 8020.269946025386 9414.459213202854 11570.982991112169 0.6761648320363192 1.2052954757822187 1.0478999111835123 1.038634782193312 1.1187522746826255 0.8478055466064326 0.6687818621862938 0.6931364389858551 0.8136265709174605 1.0 13.498223810646767 -6.925848443894688 5.377510908613716 0.7667672567756761 1.0294178807444316 0.32044260235161215 0.1536662657294758 0.20452936155726545 10.585483626029953 0.05291141931279832 0.04636946618084932 1.1861826190802615e-07 6.925848443894688 0.2626506239687555 TEDEEFLIQHLLQAPS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 TEDEEFLIQHLLQAPSPPR 19 0 Q9ULL5;Q9ULL5-2 Q9ULL5 PRR12 Proline-rich protein 12 1 TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR 169.88 2.6773000000000003e-09 274282000.0 9225.8 12178.9 8688.9 8777.5 9815.9 8888.099999999999 11864.0 11245.3 6166.51 9410.0 True False 9440.743189718187 10752.98872618299 7508.995104711302 7244.674399081368 8928.0535781379 8798.693783749111 10969.088928238802 10947.038114117646 10464.117085929201 10617.865161161993 0.8891376040685202 1.012726057731007 0.7072038484890248 0.6823098889578033 0.8408520397108561 0.8286688190327521 1.0330785672774894 1.031001801959183 0.9855198693052563 1.0 13.374206105106769 -7.256937828525933 23.18583595569785 1.0149835523722943 0.8238993703819091 0.5221873132981569 0.08692740865816126 124.41998900170336 640845.7198548679 0.03779572410197282 0.028195725456999443 5.53429329781435e-08 7.256937828525933 -0.19108418199038524 TEDEEFLIQHLLQAPS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 6 TEDEEFLIQHLLQAPSPPR 19 0 Q9ULL5;Q9ULL5-2 Q9ULL5 PRR12 Proline-rich protein 12 1 TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR;TEDEEFLIQHLLQAPS(1)PPR 178.79 4.2396000000000004e-13 230490900.0 130083.0 120663.0 130972.0 143603.0 143086.0 107647.0 111968.0 120378.0 104319.0 127790.0 True False 122853.50762350802 129917.46410730339 122545.40411153184 124044.02367100767 125110.2574749301 122474.39712782721 117174.73386038296 120728.28005034923 125185.7149163956 124100.37066170553 0.9899527855432727 1.0468741021044579 0.9874700893971341 0.9995459563061946 1.0081376615383164 0.986897915572624 0.9441932625632385 0.9728277152326279 1.0087456971232478 1.0 16.921147898938166 -6.862060741698693 4.487321040966413 0.9775408196136668 1.0072036659995622 0.21625351139356064 0.022248943863126116 0.29369292213692255 10.324248362194796 0.008079994177351226 0.0071456896040256925 1.3738498109146677e-07 6.862060741698693 0.029662846385895447 TEDFQTPS(ph)PVLR ddPTM_A459_Selumetinib_30min_R1 1 TEDFQTPSPVLR 12 0 Q5VT06;H0Y7F7 Q5VT06 CEP350 Centrosome-associated protein 350 1 TEDFQT(0.113)PS(0.887)PVLR 140.31 0.0010856 4157000.0 1040.6 993.5 839.91 1167.5 1034.5 1060.7 1327.0 989.55 572.0 806.38 True False 1064.843955344875 877.1805581343804 725.8548352953857 963.6180416892628 940.9296576558087 1050.0303210385432 1226.9033216261703 963.3039194885969 970.6422227729306 909.8867278063549 1.1703038661879444 0.9640546799151298 0.7977419750317146 1.0590527504587837 1.0341173564805095 1.1540231206252018 1.348413252036449 1.0587075182545254 1.0667725916972666 1.0 9.829543144532694 -6.493464421702657 2.4040152909722305 1.1413776104905742 0.9801976749542187 0.1849313021518042 0.12319647819482794 0.4406724337508066 5.085274623120647 0.045136763863841536 0.04935569786271561 3.210225781738496e-07 6.493464421702657 -0.16117993553635546 TEDFQTPS(ph)PVLR ddPTM_A459_Selumetinib_30min_R2 1 TEDFQTPSPVLR 12 0 Q5VT06;H0Y7F7 Q5VT06 CEP350 Centrosome-associated protein 350 1 TEDFQT(0.013)PS(0.987)PVLR 96.135 0.019187 0.0 9280.4 10259.0 10364.0 12454.0 12805.0 9037.1 9908.5 6701.5 6262.2 12297.0 True False 8764.632520384701 11045.832312115796 9697.191523469997 10757.743715651688 11196.321421847551 10281.878494374097 10369.264883320271 6721.0002555069495 7514.814980487301 11941.95365855697 0.733936236145451 0.9249602391649661 0.8120272277661624 0.9008361632640619 0.9375619552689239 0.8609879746942954 0.8683055704114382 0.5628057558815796 0.6292785247163125 1.0 13.543751254925068 -7.724134316087885 24.490960434943613 0.6970316377529355 0.8673932163910282 0.18580197072891136 0.12027924775346188 153.84866107787207 101002.27354859188 0.05347706680812018 0.030873849197117328 1.8874075323255925e-08 7.724134316087885 0.17036157863809265 TEDGDWEWS(ph)DDEMDEK ddPTM_A459_Selumetinib_30min_R1 1 TEDGDWEWSDDEMDEK 16 0 Q9UEW8-2;Q9UEW8 Q9UEW8-2 STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 TEDGDWEWS(1)DDEMDEK 110.22 0.0028343000000000005 3641200.0 1511.9 1614.3 1436.5 1276.3 1359.6 1234.5 1654.4 1665.4 994.87 1761.4 True False 1547.1243283547153 1425.2970055322903 1241.4311901296824 1053.4181641182063 1236.6244200568758 1222.0820508363179 1529.6072760349186 1621.2281820184028 1688.2217275701146 1987.4928474889186 0.7784301363949142 0.7171331496025608 0.6246217145878831 0.5300236252166335 0.622203205218715 0.6148862635557896 0.7696164934467504 0.8157152283927613 0.849422794000534 1.0 10.956733953154258 -8.061879296404616 1.0017839029837101 0.9792860824533896 0.6437442002208277 0.7325270598247389 0.06831980765833415 0.28994460099608543 0.5531821078034833 0.0705074563306814 0.025572049178054803 8.67202864219363e-09 8.061879296404616 -0.33554188223256187 TEDGDWEWS(ph)DDEMDEK ddPTM_A459_Selumetinib_30min_R2 1 TEDGDWEWSDDEMDEK 16 0 Q9UEW8-2;Q9UEW8 Q9UEW8-2 STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 TEDGDWEWS(1)DDEMDEK 125.52 0.00099553 0.0 10162.0 6255.9 6459.6 7415.9 9284.2 6780.8 8058.9 10133.0 8585.8 6958.9 True False 9597.236721709121 6735.707414111044 6043.996368680706 6405.841626858944 8117.835794198911 7714.793650026216 8433.654818407398 10162.485352391539 10303.199907295808 6757.978475606414 1.4201342541044322 0.9967044787763443 0.894349751260248 0.9478931680503953 1.2012224992282878 1.1415830455621485 1.247955264854646 1.503775927827238 1.5245979170377975 1.0 12.722376040137856 -7.240473127946383 1.7982843186567699 1.38088485055842 1.0679411611443945 0.22988632987775237 0.19398714774308098 0.4421321251982726 2.7931199459731904 0.10278158445937748 0.06496363581560792 5.748133844326165e-08 7.240473127946383 -0.3129436894140254 TEDGDWEWS(ph)DDEMDEKSEEGK ddPTM_A459_Selumetinib_30min_R1 2 TEDGDWEWSDDEMDEKSEEGK 21 1 Q9UEW8-2;Q9UEW8 Q9UEW8-2 STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 TEDGDWEWS(1)DDEMDEKSEEGK;T(0.001)EDGDWEWS(0.999)DDEMDEKSEEGK 117.62 4.166100000000001e-05 20404000.0 2553.0499999999997 2779.29 4370.46 3672.32 2221.4700000000003 2856.67 2824.94 2519.14 1843.9 2667.85 True False 2612.531097629476 2453.889434743133 3776.9755372183577 3031.018249983995 2020.538430732383 2827.9344934488336 2611.8525014277593 2452.3242238800494 3128.9636268723893 3010.294534559618 0.8678656083769783 0.8151658937593351 1.2546863749898476 1.006884281649672 0.671209546951515 0.9394211964918369 0.8676401831921913 0.8146459410287588 1.0394210901791814 1.0 11.55568893535473 TEDGDWEWS(ph)DDEMDEKSEEGK ddPTM_A459_Selumetinib_30min_R2 3 TEDGDWEWSDDEMDEKSEEGK 21 1 Q9UEW8-2;Q9UEW8 Q9UEW8-2 STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 TEDGDWEWS(1)DDEMDEKSEEGK;TEDGDWEWS(0.978)DDEMDEKS(0.021)EEGK;T(0.004)EDGDWEWS(0.995)DDEMDEKSEEGK 101.28 0.00013602 14700700.0 117968.0 116018.0 100189.0 90732.0 78023.0 70996.0 67576.0 64908.0 43317.0 96984.0 True False 111411.8108233203 124916.20754333296 93742.94881753523 78374.14507856975 68221.05320552994 80775.05456247948 70718.41789930372 65096.871533902166 51981.61037810487 94183.8199253059 1.1829187955179281 1.3263021997026656 0.9953190356037767 0.832140224729956 0.724339416893834 0.8576319650927253 0.7508552738186685 0.6911683087979269 0.5519165650674371 1.0 16.523191616473746 -5.5691908996605815 2.117573429784393 0.7534385998099472 1.2602503895967754 0.7342494378964759 0.11577439396020657 0.1523005410295378 1.356929616011774 0.033258470058234124 0.07891789760987644 2.6965538673659934e-06 5.5691908996605815 0.5068117897868282 TEDGGEFEEGAS(ph)ENNAK ddPTM_A459_Selumetinib_30min_R2 1 TEDGGEFEEGASENNAK 17 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 TEDGGEFEEGAS(1)ENNAK 120.32 0.0014712999999999998 5964000.0 19629.0 20196.0 21441.0 23991.0 22130.0 18681.0 22156.0 21486.0 17440.0 20373.0 True False 18538.098761112797 21744.968259624788 20061.5094031957 20723.384413216616 19349.83155528985 21254.138180766233 23186.297901281112 21548.520702801223 20928.48731431421 19784.77855458901 0.9369879329184075 1.0990756454325397 1.0139870581741994 1.0474408068828194 0.9780160794775093 1.0742671757544846 1.171926076266501 1.0891464184623445 1.0578075087658698 1.0 14.272103297274308 -6.9478050421482145 9.21084333654305 1.092246960408953 1.021818814524117 0.22519412914423642 0.05644146841773957 0.4501983707811125 74.71692797754166 0.019210662189488456 0.0169283538397307 1.1277035766447811e-07 6.9478050421482145 -0.07042814588483615 TEEAAADGGGGMQNEPLT(ph)PGYHGFPAR ddPTM_A459_Selumetinib_30min_R1 2 TEEAAADGGGGMQNEPLTPGYHGFPAR 27 0 O43251-6;O43251-8 O43251-6 1 TEEAAADGGGGMQNEPLT(1)PGYHGFPAR;TEEAAADGGGGMQNEPLT(1)PGYHGFPAR 188.94 4.7435e-32 7450900.0 1035.62 1034.45 1006.8699999999999 1212.98 1015.4000000000001 1001.56 1240.63 1288.97 589.12 1024.2 True False 1059.7479310342678 913.3361130972415 870.1425843410185 1001.1558134545971 923.5572492834306 991.4852157437203 1147.0482802630572 1254.7823284353674 999.6936123776036 1155.6660465528278 0.9170018745426771 0.7903114535739639 0.7529360120395668 0.8663020051864372 0.7991558219074258 0.8579340188293726 0.9925430306484507 1.0857655048170602 0.8650367598490363 1.0 10.174508846352401 -7.192014345137861 3.8400907992925273 0.9938518049322047 0.8223125571223023 0.5779452763418171 0.06522038415567995 0.15903715899097728 4.602977417737689 0.025897542778064508 0.019229977424479756 6.426664891135104e-08 7.192014345137861 -0.17153924780990237 TEEAAADGGGGMQNEPLT(ph)PGYHGFPAR ddPTM_A459_Selumetinib_30min_R2 2 TEEAAADGGGGMQNEPLTPGYHGFPAR 27 0 O43251-6;O43251-8 O43251-6 1 TEEAAADGGGGMQNEPLT(0.989)PGY(0.011)HGFPAR;TEEAAADGGGGMQNEPLT(0.986)PGY(0.014)HGFPAR 125.08 1.0139e-11 10532000.0 28995.0 29122.0 33461.0 34623.0 38091.0 24918.0 27937.0 28038.0 26022.6 33587.0 True False 27383.573976181462 31355.563758011125 31308.15568958219 29907.287671993603 33305.66804213941 28350.22831691734 29236.125856115283 28119.585938059216 31227.847132194554 32617.256040493845 0.8395425397582542 0.9613182580129871 0.9598647921429556 0.9169161144292501 1.0211057607295633 0.8691788261318164 0.8963392205591746 0.8621076494953825 0.9574026427430204 1.0 14.993347798531131 -4.9272056860096445 0.0045867983533204384 1.8340757469405755 9.060892388186538e-08 0.07706053439913862 0.05568147328319638 144575.81246123303 108.70375288418187 21049.21855447555 22431.59821947666 1.1824813886192905e-05 4.9272056860096445 -1.8340756563316516 TEEARPSPAPGPGT(ph)PTGTPTR ddPTM_A459_Selumetinib_30min_R1 4 TEEARPSPAPGPGTPTGTPTR 21 1 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 TEEARPSPAPGPGT(1)PTGTPTR;TEEARPSPAPGPGT(0.725)PT(0.184)GT(0.077)PT(0.014)R;T(0.015)EEARPS(0.007)PAPGPGT(0.825)PT(0.072)GT(0.041)PT(0.041)R;TEEARPSPAPGPGT(0.998)PT(0.002)GTPTR 267.69 8.748899999999998e-59 95578600.0 2609.23 3589.45 3272.7 3393.21 3216.43 2955.04 3696.7 2729.13 1516.5 2464.39 True False 2670.0199823222247 3169.195525309967 2828.2853156543065 2800.649571940404 2925.5044744068396 2925.3149805616463 3417.8549427697544 2656.7446069364023 2573.38973922229 2780.7184616913905 0.9601906914007279 1.1397038459557975 1.017105958268779 1.0071676117246655 1.0520678431528023 1.0519996975106585 1.2291265692143538 0.955416610324664 0.9254405919457982 1.0 11.441241968763148 -7.914879546341596 24.885968280646757 0.9551155735377476 1.0651675696382 0.306022242628361 0.07236902806773608 26.10063080528728 7626.280204638464 0.038933388702949476 0.018702990596505157 1.2165233624514919e-08 7.914879546341596 0.11005199610045235 TEEARPSPAPGPGT(ph)PTGTPTR ddPTM_A459_Selumetinib_30min_R2 4 TEEARPSPAPGPGTPTGTPTR 21 1 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 TEEARPSPAPGPGT(0.875)PT(0.104)GT(0.013)PT(0.008)R;T(0.001)EEARPSPAPGPGT(0.901)PT(0.076)GT(0.023)PTR;T(0.003)EEARPS(0.002)PAPGPGT(0.928)PT(0.06)GT(0.006)PT(0.002)R;TEEARPS(0.021)PAPGPGT(0.974)PT(0.005)GTPTR 119.77 0.00039344 126552900.0 50726.5 43116.600000000006 58579.7 55433.1 52497.3 41919.9 39686.9 45786.2 39698.3 38388.8 True False 47907.324204268596 46423.50457827978 54810.745878754875 47883.0161525688 45902.11984218337 47693.985714035785 41532.41948810045 45919.43026168656 47639.069263178884 37280.415597919164 1.285053383550332 1.2452517986647913 1.4702289392346308 1.284401350805795 1.2312663125124987 1.2793308483582964 1.1140546268593265 1.2317306426232435 1.2778577840167076 1.0 15.186130322634854 -6.724804736835596 1.229432587723056 1.1750327625402102 1.3254566755557688 0.3628230292714678 0.09225885237257855 0.560963189693308 1.7886604073676349 0.045235968581599416 0.042212317959044086 1.8844961874716754e-07 6.724804736835596 0.15042391301555869 TEEARPSPAPGPGTPT(ph)GTPTR ddPTM_A459_Selumetinib_30min_R1 1 TEEARPSPAPGPGTPTGTPTR 21 1 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 1 TEEARPSPAPGPGT(0.029)PT(0.943)GT(0.025)PT(0.003)R 133.24 6.0761e-05 53897000.0 747.94 687.48 765.15 813.71 774.72 826.86 810.98 663.12 428.67 551.84 True False 765.3655467621039 606.9895219992186 661.2468326681003 671.6108237284539 704.6467127879253 818.5425391288117 749.8071256762565 645.5319034826725 727.4216811819445 622.6740393767939 1.2291592363929664 0.9748110305140179 1.061947007345789 1.078591335525468 1.1316462036753197 1.3145602472010134 1.2041727746136717 1.036709197204939 1.1682222722983404 1.0 9.282333321176997 -4.470654181053888 22.057334349867993 1.1159875321501163 2.8349032788606157 0.11841018063332154 0.0970408381499663 439.37514246234514 280698.33980252844 0.024850896832969076 18367.992278347232 3.383341368503612e-05 4.470654181053888 1.7189157467104994 TEEDETS(ph)EDANCLALSGHDK ddPTM_A459_Selumetinib_30min_R2 1 TEEDETSEDANCLALSGHDK 20 0 P51003 P51003 PAPOLA Poly(A) polymerase alpha 1 T(0.058)EEDET(0.459)S(0.483)EDANCLALSGHDK 110.13 0.00061081 0.0 11496.0 10648.0 13941.0 13190.0 14407.0 12295.0 13441.0 13942.0 10432.0 12251.0 True False 10857.098342134226 11464.667361283648 13044.051237813132 11393.499245980873 12597.063859785849 13988.524647102453 14066.033132836234 13982.568911777644 12518.691494433819 11897.281798079315 0.9125696546825498 0.963637539722266 1.0963891970617146 0.9576556594482134 1.058818650645016 1.1757748437429418 1.1822896499860194 1.1752742474365006 1.0522312328900896 1.0 13.538344374563454 -6.524242833863715 4.630529744503159 1.131708014716883 0.9904570516513023 0.44062324854911583 0.07018620135796874 0.17447815239025785 9.86825800097882 0.023183896038496684 0.024455394602679127 2.990591992568254e-07 6.524242833863715 -0.14125096306558071 TEEGEIDYS(ph)AEEGENR ddPTM_A459_Selumetinib_30min_R2 1 TEEGEIDYSAEEGENR 16 0 B7WPG3;V9GYK2;Q8WVV9-2;Q8WVV9-5;Q8WVV9;C9IYN3;Q8WVV9-3;Q8WVV9-4 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1 TEEGEIDYS(1)AEEGENR 226.74 4.2596e-51 0.0 14705.0 12433.0 14073.0 14573.0 14010.0 12560.0 12992.0 13542.0 14243.0 12803.0 True False 13887.754968779038 13386.571121604018 13167.558501523863 12588.132260172795 12249.938549010882 14290.025991671962 13596.15374315961 13581.404978001212 17091.99798267071 12433.344123811085 1.1169766420429572 1.0766669842240921 1.0590520434728967 1.0124494371602952 0.9852488941853573 1.1493308517299983 1.0935234807119696 1.0923372539807272 1.374690333708197 1.0 13.601926761375454 -8.02761945332423 24.834216524296984 1.202734741641867 1.0695840475535725 0.18697611492982424 0.0950719102893456 915.3847507014636 823068.2214777848 0.05990449971902346 0.022778050207482015 9.383838973272778e-09 8.02761945332423 -0.1331506940882945 TEEGEIDYS(ph)AEEGENRR ddPTM_A459_Selumetinib_30min_R1 2 TEEGEIDYSAEEGENRR 17 1 B7WPG3;V9GYK2;Q8WVV9-2;Q8WVV9-5;Q8WVV9;C9IYN3;Q8WVV9-3;Q8WVV9-4 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1 TEEGEIDYS(1)AEEGENRR;TEEGEIDYS(1)AEEGENRR 171.26 1.3182e-06 21930800.0 5358.9 4873.7 5727.9 6495.200000000001 5473.7 4931.5 5512.8 4889.9 2871.7 4696.2 True False 5483.7519433957805 4303.08493827834 4950.082641102546 5360.935250004367 4978.604801460223 4881.893587443746 5096.965057619255 4760.203967366271 4873.065159330464 5299.003014861734 1.034864846843056 0.8120555746448503 0.9341535808187699 1.0116875259306204 0.9395361330229642 0.9212853009805521 0.9618724585217563 0.8983206754205778 0.919619246424908 1.0 12.37150523286327 -5.51264216767311 24.996885865792944 0.9470699881660525 0.9108713084248307 0.022304843828914067 0.06015539881170049 1460.9808789712197 3567590.664725296 0.015420241695561655 0.02902269158508487 3.071551718499679e-06 5.51264216767311 -0.03619867974122182 TEEGEIDYS(ph)AEEGENRR ddPTM_A459_Selumetinib_30min_R2 2 TEEGEIDYSAEEGENRR 17 1 B7WPG3;V9GYK2;Q8WVV9-2;Q8WVV9-5;Q8WVV9;C9IYN3;Q8WVV9-3;Q8WVV9-4 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 1 TEEGEIDY(0.003)S(0.997)AEEGENRR;TEEGEIDYS(1)AEEGENRR 128.79 0.00050725 57936000.0 102951.0 80748.0 89854.0 103451.0 101760.0 82376.0 78474.0 92616.0 81504.0 77813.0 True False 97229.3955655063 86941.11195425753 84072.89146563821 89360.79533707109 88975.99905405752 93722.54626512498 82123.19649328101 92885.49722659585 97807.0774120338 75566.33650754597 1.286676052580597 1.1505270199988546 1.1125706941905644 1.182547672244871 1.1774555068601542 1.2402684925153935 1.0867695893273888 1.2291914828677768 1.2943207509109151 1.0 16.20545606148646 -10.68735032122624 4.907785247378438 0.9999849282079132 1.1900091836030582 0.4442924539740265 0.06535585743005762 1.0781094722888574e-05 1.8354970895170198e-06 0.06329673616762552 0.015350496243842295 2.054232891958163e-11 10.68735032122624 0.190024255395145 TEEGQAS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 TEEGQASPVK 10 0 S4R3B8;Q3KQV3 S4R3B8 ZNF792 Zinc finger protein 792 1 TEEGQAS(1)PVK 105.36 0.012559 4530800.0 1617.0 2025.2 1820.0 1737.5 1840.1 1709.0 1921.1 1621.8 1017.8 1634.1 True False 1654.6729538657141 1788.0886425100628 1572.8539965443927 1434.0782419144268 1673.6632798960406 1691.809011647848 1776.1898803135173 1578.7845956511612 1727.1322628291766 1843.8526524819124 0.8973997741296987 0.9697567970538271 0.8530258610563362 0.7777618455488241 0.9076990385556086 0.9175402434519881 0.9633035904049503 0.8562422781050552 0.9366975503733312 1.0 10.848507655165106 -6.512378999071877 24.0737871412736 0.9258964707997271 0.8751297795600383 0.19674457412169477 0.05598941412252187 645.1534097992841 1479210.5963997897 0.01887931368634031 0.020079205777310684 3.0734135448996154e-07 6.512378999071877 -0.0507666912396888 TEEGQAS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 TEEGQASPVK 10 0 S4R3B8;Q3KQV3 S4R3B8 ZNF792 Zinc finger protein 792 1 TEEGQAS(1)PVK;TEEGQAS(1)PVK 117.27 0.006076399999999999 19223100.0 107291.0 74603.0 92146.0 93045.0 97334.0 72412.0 90033.0 92086.0 64602.0 82192.0 True False 101328.19573990286 80324.81021354647 86217.42668097896 80372.11048842221 85106.03274299968 82386.09570931125 94219.71289700504 92353.95501434206 77524.20513069535 79818.90339953746 1.2694761694820533 1.0063381829674691 1.0801630066177854 1.0069307778649332 1.0662390626565894 1.0321627108421119 1.1804185335068262 1.157043646065391 0.9712511927487166 1.0 16.28444283791609 -4.751591446049915 24.999542244578173 1.0632687214982872 1.2694765842574134 0.4878182673500604 0.06531834346309155 376.06419665327036 954594.7444479764 0.01652392671726315 0.21679071028670563 1.771774936829337e-05 4.751591446049915 0.20620786275912617 TEELIES(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 TEELIESPK 9 0 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 TEELIES(1)PK;TEELIES(1)PK 134.98 0.0027665 15139800.0 136977.0 92516.0 98314.0 100911.0 91815.0 86659.0 147219.0 137637.0 96486.0 75883.0 True False 129364.36670237656 99611.67971417321 91988.58427618974 87166.74771881562 80280.37886348553 98595.49063792203 154064.97520891434 138037.50088296813 115785.89604408974 73692.0606222882 1.7554722396139677 1.3517287869684784 1.2482835124896445 1.1828512730237317 1.0894033656483841 1.337939118615198 2.0906590738258894 1.8731665218385631 1.5712126254353949 1.0 16.169221575289782 -7.043427995573159 24.08146995710212 1.7076345534148287 1.3046711500852182 0.1726844189912844 0.31036464522789875 408.3508470543887 226435.1334041769 0.11676418081975541 0.09045336842196994 9.048404445182628e-08 7.043427995573159 -0.40296340332961056 TEELIES(ph)PKLESSEGEIIQTVDR ddPTM_A459_Selumetinib_30min_R1 5 TEELIESPKLESSEGEIIQTVDR 23 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 T(0.001)EELIES(0.88)PKLES(0.11)S(0.01)EGEIIQTVDR;TEELIES(1)PKLESSEGEIIQTVDR;TEELIES(1)PKLESSEGEIIQTVDR;T(0.001)EELIES(0.995)PKLES(0.001)S(0.001)EGEIIQT(0.001)VDR;T(0.001)EELIES(0.996)PKLES(0.001)S(0.001)EGEIIQT(0.001)VDR 120.32 5.8336e-06 368262400.0 5505.44 6691.119999999999 7445.880000000001 7866.4400000000005 5627.950000000001 5554.250000000001 6163.540000000001 5633.99 3740.15 5206.1 True False 5633.706040278573 5907.720559782706 6434.7703932911945 6492.713925367093 5118.902916195278 5498.3792878555005 5698.619215505479 5484.558283421317 6346.761380252056 5874.353646708331 0.9590341983301254 1.0056800994766584 1.095400580265863 1.1052643943228133 0.8713984931880349 0.9359973230308485 0.9700844651562092 0.9336445527917043 1.0804186744542417 1.0 12.52021440578866 -4.752604799746558 22.725481341220757 0.9970454858621222 0.9590339593243633 0.026365448426787008 0.07258102541111972 604.1983550445773 1553806.6786551487 0.019405093722109135 0.20917471857664308 1.7676456151104964e-05 4.752604799746558 -0.038011526537758855 TEELIES(ph)PKLESSEGEIIQTVDR ddPTM_A459_Selumetinib_30min_R2 4 TEELIESPKLESSEGEIIQTVDR 23 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 T(0.004)EELIES(0.991)PKLES(0.004)SEGEIIQTVDR;T(0.006)EELIES(0.993)PKLES(0.001)SEGEIIQTVDR;T(0.002)EELIES(0.995)PKLES(0.001)S(0.001)EGEIIQTVDR;T(0.008)EELIES(0.992)PKLESSEGEIIQTVDR 76.015 0.00047949 76493000.0 40480.7 40368.2 35357.600000000006 35557.8 34453.600000000006 21905.8 30992.4 29908.3 18920.42 29683.2 True False 38230.944751081515 43464.311135778626 33082.73051044412 30714.766299373652 30125.230748908012 24923.125108946453 32433.608010275544 29995.328201414402 22705.032680705095 28826.168889784345 1.3262582654412363 1.5078074128394447 1.147663105594592 1.0655167676568564 1.04506536626808 0.864600676012098 1.1251445911624292 1.0405589558605686 0.7876534952499876 1.0 14.815091489327774 -5.523377529378238 2.1419576649125776 0.9885547417552599 1.4220202479482782 0.7255085695774421 0.10350713115456817 0.16154580223680698 1.456672871963369 0.029534353018205207 0.07371128972083404 2.9965564993110865e-06 5.523377529378238 0.43346550619301827 TEENVSDGS(ph)PNAGSVEQTPK ddPTM_A459_Selumetinib_30min_R2 2 TEENVSDGSPNAGSVEQTPK 20 0 P46527;H7C2T1 P46527 CDKN1B Cyclin-dependent kinase inhibitor 1B 1 TEENVSDGS(1)PNAGSVEQTPK;TEENVSDGS(1)PNAGSVEQTPK 296.6 5.126299999999997e-87 10740100.0 90641.0 92381.0 99275.0 114172.0 113709.0 89847.0 94265.0 95831.0 75452.0 106300.0 True False 85603.536084672 99466.3256482666 92887.7545824473 98621.57664231442 99423.85884864212 102222.60870013949 98648.5092825538 96109.8523443239 90544.50830502503 103230.84279943118 0.8292437973309241 0.9635330193082051 0.899806221314306 0.9553499125637076 0.9631216422577726 0.9902332086811438 0.9556108097869503 0.9310187705340858 0.8771071304817821 1.0 16.655514550874962 -4.756512064663947 24.9974457011748 0.9469525878459375 0.8292436168911574 0.5007685360348304 0.035670893593097386 133.068131855184 675009.4123152229 0.008969439005678568 0.0718257675424971 1.7518137682943972e-05 4.756512064663947 -0.11770897095478006 TEEPLGS(ph)PHPSGTVESPGEGPQDTR ddPTM_A459_Selumetinib_30min_R1 2 TEEPLGSPHPSGTVESPGEGPQDTR 25 0 A0A0A0MR84;M0R202;A0A0B4J2G2;Q9NWS9-2;Q9NWS9 A0A0A0MR84 ZNF446 Zinc finger protein 446 1 T(0.005)EEPLGS(0.995)PHPSGTVESPGEGPQDTR;TEEPLGS(1)PHPSGTVESPGEGPQDTR 158.99 3.7609e-13 23188000.0 3724.8 3913.7 3086.3 3666.0 5861.7 3490.6000000000004 5530.7 3794.1 930.5699999999999 2257.01 True False 3811.580592800872 3455.4821845702304 2667.1974118323974 3025.801919342902 5331.510269967191 3455.4877332112205 5113.514846207887 3693.4681430263126 1579.109323856305 2546.7192186391303 1.496663065525392 1.3568367330328266 1.0473072148321267 1.1881175974160885 2.093481774883745 1.3568389117735962 2.0078832439723584 1.450284788363894 0.6200563109976925 1.0 11.314424192759997 -8.226051701760763 9.23299368280059 0.8104896374679279 1.5018696898925683 0.4253839997787412 0.3206227768227043 0.38041559019590987 97.42665343062123 0.22977935447147607 0.08525116404645404 5.942214137099059e-09 8.226051701760763 0.6913800524246404 TEEPLGS(ph)PHPSGTVESPGEGPQDTR ddPTM_A459_Selumetinib_30min_R2 3 TEEPLGSPHPSGTVESPGEGPQDTR 25 0 A0A0A0MR84;M0R202;A0A0B4J2G2;Q9NWS9-2;Q9NWS9 A0A0A0MR84 ZNF446 Zinc finger protein 446 1 T(0.001)EEPLGS(0.968)PHPS(0.029)GT(0.002)VESPGEGPQDTR;TEEPLGS(0.996)PHPS(0.004)GTVESPGEGPQDTR;T(0.001)EEPLGS(0.999)PHPSGTVESPGEGPQDTR 115.31 5.1628e-08 25368000.0 30100.4 22343.9 41330.4 63929.6 64656.1 39213.5 36911.5 41894.5 42636.3 52268.3 True False 28427.540269448255 24057.605283037745 38671.24706113705 55222.27819528874 56533.4226851322 44614.803680288904 38627.95788874968 42016.40605899215 51164.751357757756 50759.17836964733 0.5600472896237262 0.4739557663412371 0.7618572306178513 1.087926951715795 1.1137576395235294 0.878950469910825 0.7610043962383796 0.8277597748531893 1.0079901409190846 1.0 15.631381096253511 -5.467312835455603 3.9715073973258437 0.942289319811166 0.5239825223125533 0.7256546510745343 0.10683961728179185 0.12918835564721273 4.098896865204407 0.032750096441702334 0.0700186622569835 3.4094722854144044e-06 5.467312835455603 -0.41830679749861277 TEES(ph)PASDEAGEK ddPTM_A459_Selumetinib_30min_R1 1 TEESPASDEAGEK 13 0 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 T(0.003)EES(0.997)PASDEAGEK 193.45 0.00018677 16481000.0 5469.6 8388.9 3197.8 3388.2 3596.3 4650.9 5520.0 5268.9 3054.3 5642.0 True False 5597.031038011076 7406.723688106195 2763.5563242580542 2796.514474391056 3271.0152999783354 4604.116168679328 5103.621955822505 5129.151656200767 5182.9240227541295 6366.205657733892 0.8791784838448636 1.1634439863104713 0.43409787129650584 0.4392749189611478 0.5138092414599567 0.7232119752660024 0.8016740630460852 0.8056842540061037 0.8141307870658765 1.0 12.63621804807644 -8.365060434455822 0.9357586911979814 0.9867363870228976 0.6913686243937842 0.15953569268406442 0.20750167510645523 1.1485447060041505 2.187097373157659 0.2207126942761279 0.07729936124525752 4.314590327625876e-09 8.365060434455822 -0.29536776262911335 TEES(ph)PASDEAGEK ddPTM_A459_Selumetinib_30min_R2 1 TEESPASDEAGEK 13 0 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 TEES(0.973)PAS(0.027)DEAGEK 118.73 0.0033659 33613000.0 190500.0 146990.0 187250.0 155940.0 160960.0 136300.0 170510.0 205680.0 140070.0 140250.0 True False 179912.77263192175 158263.66035265592 175202.53886238465 134700.7029884958 140738.76579934254 155074.0877917906 178439.05285915523 206278.49474784292 168087.91388279776 136200.61808673752 1.320939472663382 1.1619892962003142 1.2863564154371847 0.9889874574777148 1.0333195823657346 1.1385711017334281 1.310119259117596 1.514519520142539 1.2341200520525777 1.0 17.05537372484001 -7.263125614986087 22.965550288613375 1.3075663574545866 1.1482337537102043 0.08431517800920063 0.1518485834682987 83.17121031418398 1132707.2759385288 0.06128865350033858 0.04379972120842189 5.456000293538423e-08 7.263125614986087 -0.1593326037443823 TEES(ph)PASDEAGEKEAK ddPTM_A459_Selumetinib_30min_R1 1 TEESPASDEAGEKEAK 16 1 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 T(0.165)EES(0.67)PAS(0.165)DEAGEKEAK 71.263 0.022224 8621900.0 2943.0 3319.7 3772.3 3829.9 2425.6 2595.3 2514.8 2259.8 1193.8 1841.0 True False 3011.5661739188604 2931.027980713341 3260.042379760668 3161.079861126942 2206.204908274461 2569.1936383438588 2325.106611322904 2199.862763135093 2025.7914082977713 2077.310282858577 1.4497430637924047 1.410972643277906 1.5693574554854361 1.5217177169974794 1.062048807286754 1.2367885816308595 1.119287104343091 1.0589957510381511 0.9751992396196534 1.0 11.020501008840775 -6.262039358898061 24.99800529883104 1.0886014837785316 1.4882644943271515 0.8709987484388715 0.0776826817662699 19.97186855108853 832124.4780387861 0.025193567024811795 0.030331428202511106 5.46966390608694e-07 6.262039358898061 0.39966301054861986 TEES(ph)PASDEAGEKEAK ddPTM_A459_Selumetinib_30min_R2 1 TEESPASDEAGEKEAK 16 1 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 T(0.204)EES(0.778)PAS(0.019)DEAGEKEAK 63.43600000000001 0.033883 5869500.0 42446.0 40233.0 47234.0 32196.0 31003.0 22404.0 21721.0 24672.0 15377.0 37649.0 True False 40087.02124480074 43318.741730515154 44195.015864490764 27810.849258802136 27108.125969663393 25489.94763673715 22731.069539344964 24743.79143533054 18452.829669278086 36561.975546150396 1.0964128892379146 1.1848030934716869 1.2087699092929363 0.7606495229913892 0.7414294650311258 0.697170961250779 0.6217133839130943 0.6767629775392651 0.50470001671507 1.0 15.158056404913514 -5.818118783104564 4.818375512060735 0.6922674767246503 1.1668495025560173 0.7423551874377425 0.12102611040612431 0.0900797812729566 4.2622058804493985 0.03310729464537355 0.05146792113929528 1.520131704374115e-06 5.818118783104564 0.474582025831367 TEESEPLPSCPGS(ph)PPLPDDLLPLDCK ddPTM_A459_Selumetinib_30min_R2 2 TEESEPLPSCPGSPPLPDDLLPLDCK 26 0 O94864;O94864-2 O94864 SUPT7L STAGA complex 65 subunit gamma 1 TEESEPLPS(0.004)CPGS(0.996)PPLPDDLLPLDCK;TEESEPLPS(0.003)CPGS(0.997)PPLPDDLLPLDCK 94.73 2.9665e-06 16233300.0 129990.0 105929.0 132171.0 135967.0 142779.0 124588.0 156282.0 168358.0 131950.0 124860.0 True False 122765.67619119954 114053.41368458077 123667.26175690422 117448.06004384226 124841.82555954494 141748.866102741 163549.42266690813 168847.89390683288 158343.68699104106 121254.96737476019 1.0124589437377047 0.9406081759279871 1.0198943963647147 0.9686041123647166 1.029581123663981 1.1690149209693055 1.3488059599358875 1.3925029016335324 1.3058738163002555 1.0 16.88768432491299 -6.880992147312781 2.566859309110982 1.2932021579792665 0.9865493514891366 0.6010551229615275 0.10239457105994572 0.16722979713795497 2.238570589748328 0.03843232930875819 0.03312293109608498 1.315248613619437e-07 6.880992147312781 -0.30665280649012994 TEESKADSPPPS(ph)YPTQQAEQAPNTCECHVCK ddPTM_A459_Selumetinib_30min_R2 1 TEESKADSPPPSYPTQQAEQAPNTCECHVCK 31 1 A0A1B0GVL4;P78312-6;P78312-2;P78312-5;P78312;D6RFZ4;P78312-3;E7EUR8;P78312-4 A0A1B0GVL4;E7EUR8 FAM193A Protein FAM193A 1 TEESKADS(0.1)PPPS(0.492)Y(0.386)PT(0.021)QQAEQAPNTCECHVCK 121.97 1.1712e-16 16049000.0 38313.0 30350.0 32815.0 30723.0 26518.0 26514.0 26962.0 27240.0 20174.0 30126.0 True False 36183.716839090885 32677.747409368792 30703.71862627057 26538.474399868857 23186.571766072117 30166.06282987186 28215.78642418946 27319.263890175243 24209.363708656827 29256.184103251788 1.2367886635998133 1.1169517970642215 1.049477899028462 0.9071064875107598 0.7925357484845387 1.031100389695693 0.9644383671024722 0.9337945028565342 0.8274956030908346 1.0 14.836453989958153 -5.282278954488805 1.6495310252376711 0.9212210493903243 1.2268784539022108 0.6796421416613487 0.0712059243401449 0.279304749250902 1.2925826796584365 0.021527082745937006 0.09888386884359303 5.220607530743285e-06 5.282278954488805 0.3056574045118865 TEESPAS(ph)DEAGEKEAK ddPTM_A459_Selumetinib_30min_R1 2 TEESPASDEAGEKEAK 16 1 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 T(0.002)EES(0.078)PAS(0.92)DEAGEKEAK;TEES(0.452)PAS(0.548)DEAGEKEAK 119.0 0.0081557 36654000.0 4073.4 4485.4 4574.6 4544.3 3330.3 3598.5 3885.3 3573.8999999999996 2432.2 3318.9 True False 4168.302294543353 3960.2472827941115 3953.3944464791116 3750.723312075814 3029.0749530122184 3562.302357176581 3592.228692927026 3479.108562336714 4127.265759140424 3744.9131438236464 1.113057134961324 1.0575004361117448 1.055670530837092 1.0015514827791803 0.8088505224768605 0.9512376443367615 0.9592288405544365 0.9290224976444875 1.1020991944625949 1.0 11.870716543151717 -5.839396257799374 3.527551341250055 0.9513172394350595 1.07588743099299 0.35487029429164185 0.06964376399401292 0.24948976446751597 6.130694444366197 0.020466454558235158 0.03287906320896865 1.447450571910973e-06 5.839396257799374 0.12457019155793048 TEESPASDEAGEKEAKS(ph)D ddPTM_A459_Selumetinib_30min_R1 2 TEESPASDEAGEKEAKSD 18 2 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 TEESPASDEAGEKEAKS(1)D;TEESPASDEAGEKEAKS(1)D 114.39 0.0012411 101022000.0 9834.3 15857.0 13058.7 14657.8 9582.3 14075.599999999999 12199.0 10937.3 8441.5 11561.900000000001 True False 10063.420055783296 14000.455068280697 11285.400266304545 12098.09039098318 8715.582656892475 13934.012243622254 11278.819608528756 10647.207274642647 14324.608957233733 13045.982487443016 0.7713807730057519 1.073162184738204 0.8650479392538614 0.9273422222226498 0.6680664078218236 1.0680692126510196 0.8645435190017169 0.8161292018359498 1.0980092124929202 1.0 13.671317976551684 -8.266306843856805 24.9769382431032 1.0490046162068984 0.8875818618181864 0.23959390674664427 0.11884161460743527 620.0999757665247 3181925.938106646 0.09819127685015329 0.028492527789122223 5.416180835444152e-09 8.266306843856805 -0.161422754388712 TEESPASDEAGEKEAKS(ph)D ddPTM_A459_Selumetinib_30min_R2 3 TEESPASDEAGEKEAKSD 18 2 A6NL93;A6NEL0;P05114 A6NL93 HMGN1 Non-histone chromosomal protein HMG-14 1 TEESPASDEAGEKEAKS(1)D;TEESPASDEAGEKEAKS(1)D;TEESPASDEAGEKEAKS(1)D 85.57600000000002 0.015432 61871400.0 85393.0 75407.0 71625.0 59392.0 53262.0 40817.8 52409.7 44044.2 27380.3 63385.0 True False 80647.19891526342 81190.4744282792 67016.72547940354 51302.707143085376 46570.751391678605 46440.0814429035 54846.85489785036 44172.36133009017 32857.125069502144 61554.910355991946 1.3101667835897184 1.3189926515809776 1.0887307786141536 0.8334462164981679 0.7565724833704557 0.7544496641181914 0.8910232275646779 0.7176090595311914 0.5337856050716144 1.0 15.909586327464266 -5.594577025920282 1.9431416184545316 0.7650083561252545 1.3273816544682364 0.7857741575047699 0.11326606364095444 0.1459266646195074 1.0962880523745802 0.03355447570056509 0.0810389265211114 2.543448650286692e-06 5.594577025920282 0.5623732983429819 TEFLDLDNSPLSPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 TEFLDLDNSPLSPPSPR 17 0 Q8NCF5 Q8NCF5 NFATC2IP NFATC2-interacting protein 1 TEFLDLDNSPLSPPS(1)PR;TEFLDLDNSPLSPPS(1)PR;TEFLDLDNSPLSPPS(1)PR 207.1 5.504899999999999e-09 36099200.0 28814.8 28640.199999999997 28936.600000000002 32501.6 32649.7 27395.199999999997 26077.7 28112.5 26502.399999999998 28160.7 True False 27213.388770783702 30836.811247242294 27074.85065978793 28074.826011612724 28547.952793978624 31168.6401311347 27290.36472198225 28194.302720725093 31803.620538926658 27347.627420714405 0.9950913968562763 1.127586344981613 0.9900255785728652 1.0265909206568868 1.0438913897282012 1.139720080708942 0.9979061182218395 1.030959735079957 1.1629389288387435 1.0 14.739128055095815 -6.546294249816945 24.99916152207626 1.067058426758939 1.037873509094646 0.05625036067954403 0.06111480987299627 821.6087795797094 877169.0154075248 0.0197066730170071 0.019708185197119397 2.842534537536001e-07 6.546294249816945 -0.029184917664292875 TEFLHSQNSLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 TEFLHSQNSLSPR 13 0 Q96FS4;F6RY50 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 TEFLHSQNS(0.024)LS(0.976)PR;TEFLHSQNS(0.024)LS(0.976)PR 120.32 0.0020232 28285000.0 4788.3 5700.5 5744.6 6094.8 6092.1 4917.700000000001 6300.5 5674.2 2526.8 4055.4 True False 4899.858073590103 5033.082809909446 4964.514872829078 5030.457593565498 5541.070630647614 4868.232402914347 5825.24821243835 5523.70178360083 4287.795049829791 4575.950092941162 1.0707848586785507 1.0998989734773232 1.0849145580690038 1.0993252748375593 1.2109115086712248 1.0638735790462528 1.2730139302490096 1.2071158276226972 0.9370283684789575 1.0 12.159855602281247 -6.019010907226751 24.172686572919048 1.1331849860067031 1.0875778049227183 0.0 0.09618729265604054 1802.390968921129 2291773.059996269 0.027805688496973575 0.036542324796506265 9.571700318420926e-07 6.019010907226751 -0.04560718108398487 TEFLHSQNSLS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TEFLHSQNSLSPR 13 0 Q96FS4;F6RY50 Q96FS4 SIPA1 Signal-induced proliferation-associated protein 1 1 TEFLHS(0.038)QNS(0.301)LS(0.661)PR;TEFLHS(0.008)QNS(0.258)LS(0.733)PR 73.833 0.033512 48790000.0 79208.0 60777.0 78455.0 97471.0 102976.0 66112.0 81274.0 70763.0 64104.0 89761.0 True False 74805.93645474665 65438.400471143555 73407.29071534544 84195.28165314645 90039.23426287976 75218.32789501717 85053.40204137581 70968.90861455469 76926.59121541287 87169.36670291395 0.8581677174470742 0.75070409418216 0.8421225654366438 0.9658815342790821 1.0329228910168264 0.8628986390525506 0.9757258227107505 0.8141496410823678 0.882495699178245 1.0 16.41153360778147 -5.599054322266824 5.222664620638534 0.9281744269586948 0.8024088571624705 0.3925996485917733 0.0671168682626958 0.2042243370626053 9.866392522041295 0.018817850350098017 0.03347332860042407 2.5173620322894267e-06 5.599054322266824 -0.12576556979622433 TEFQQVLS(ph)NR ddPTM_A459_Selumetinib_30min_R1 1 TEFQQVLSNR 10 0 A0A087X0P0;Q02224-3;Q02224 A0A087X0P0 CENPE Kinesin-like protein;Centromere-associated protein E 1 TEFQQVLS(1)NR 74.533 0.041143 6227600.0 418.93 525.37 477.09 396.49 436.13 391.42 457.93 354.01 394.5 466.13 True False 428.6902539041209 463.8594361621133 412.3037984677828 327.25046453907964 396.6821185050055 387.48267018092486 423.38797141844185 344.6205048134588 669.4376868600019 525.9623259906947 0.8150588601505753 0.881925212587032 0.7839036716007627 0.6221937358777088 0.7542025329624533 0.7367118347327793 0.8049777531517198 0.6552189915206129 1.2727863836997435 1.0 9.038815654590906 -8.258363230715846 24.999809174952464 1.1363932055391628 0.7582164135483503 0.723355682468429 0.09390252527579622 127.30689397635811 1034643.2224777552 0.06916429309119734 0.023629083355809693 5.516158915154105e-09 8.258363230715846 -0.37817679199081244 TEGS(ph)SPPDSK ddPTM_A459_Selumetinib_30min_R1 1 TEGSSPPDSK 10 0 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 TEGS(0.944)S(0.056)PPDSK 119.27 0.0054512 3414700.0 2540.0 3997.3 3172.7 3254.2 3030.9 3808.6 2902.5 2947.3 1932.9 2931.2 True False 2599.177058020356 3529.294257705646 2741.8647663936226 2685.915058899526 2756.755630148858 3770.288941932119 2683.5620881838454 2869.128029820365 3279.990126569579 3307.4480723058473 0.7858557417073196 1.0670747296858192 0.8289970715948631 0.8120807946735175 0.833499293074898 1.1399389679014957 0.811369378903945 0.8674748528463216 0.9916981475941584 1.0 11.69150279070045 TEGS(ph)SPPDSK ddPTM_A459_Selumetinib_30min_R2 2 TEGSSPPDSK 10 0 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 TEGS(0.531)S(0.469)PPDSK;T(0.002)EGS(0.587)S(0.411)PPDSK 99.752 0.018158 7649900.0 43573.0 35609.0 33528.0 43114.0 37561.0 35513.0 52066.0 79811.0 41392.0 65865.0 True False 41151.38709653919 38340.095799018556 31370.844982526276 37241.79882420161 32842.251380399546 40404.593395083284 54487.17216682175 80043.23679657775 49671.55658911087 63963.30631217813 0.6433592862710457 0.5994076605717752 0.4904506472729585 0.5822369256904885 0.5134545612778405 0.631683940756367 0.8518504640909691 1.251393047224923 0.7765633056347149 1.0 15.964956894304192 -7.347067023975256 3.0308860446972257 1.0153684645309091 0.5670520531638256 0.7399213050571796 0.11650985267520321 0.12174631729116879 2.1715329988999743 0.050745223168664574 0.03252165614904563 4.497104464410836e-08 7.347067023975256 -0.44831641136708356 TEGSS(ph)PPDSK ddPTM_A459_Selumetinib_30min_R1 2 TEGSSPPDSK 10 0 Q96JN0-3;A0A1P0AZG4 Q96JN0-3 LCOR Ligand-dependent corepressor 1 T(0.001)EGS(0.033)S(0.966)PPDSK;TEGS(0.031)S(0.969)PPDSK 125.72 0.003578 9023200.0 5034.299999999999 8127.099999999999 7336.5 7739.6 6194.7 6999.700000000001 5235.4 6151.0 4444.2 5502.6 True False 5151.589394957432 7175.5753538137105 6340.2435965098575 6388.024150285408 5634.390478763117 6929.289373219099 4840.489562955278 5987.855498736153 7541.482808474582 6208.912309862909 0.8297088343112995 1.1556895951671358 1.0211520601504274 1.0288475390670244 0.9074682001568682 1.1160230693243751 0.7796034669818288 0.9643968540551612 1.2146222127336013 1.0 12.60012484093279 -8.229701091094467 24.78410854820735 1.1073111974822358 0.9805817479897186 0.16030563721227076 0.12032308613249243 951.1905477441579 742777.4763302074 0.07850992537726076 0.029667390305500176 5.892490742697137e-09 8.229701091094467 -0.1267294494925172 TEGT(ph)PPPPGQPAK ddPTM_A459_Selumetinib_30min_R1 1 TEGTPPPPGQPAK 13 0 F8VWT9;J3KPF0;Q9Y4D8-2;Q9Y4D8-4;Q9Y4D8;A0A494C150 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 1 T(0.001)EGT(0.999)PPPPGQPAK 116.9 0.0087005 9801700.0 7899.4 9027.3 9885.5 10539.0 9122.8 8619.6 8901.0 8105.2 4838.9 7420.8 True False 8083.440650443299 7970.379519322084 8543.103397164612 8698.561491531598 8297.644350761153 8532.894649970618 8229.590403763792 7890.223766599951 8211.259880727159 8373.331964713161 0.965379216363149 0.9518766905349989 1.0202752540048454 1.0388411122584196 0.9909608726524912 1.0190560562903614 0.9828334095011253 0.9423039478012909 0.9806442543220542 1.0 13.03158610724951 -9.957248858780984 11.824176345834783 0.9999998011257182 0.9889015127637585 0.01402043178484802 0.029312601111601024 0.0 0.0 0.03127738778268312 0.007585880795376818 1.1034461436336596e-10 9.957248858780984 -0.011098288361959696 TEGT(ph)PPPPGQPAK ddPTM_A459_Selumetinib_30min_R2 2 TEGTPPPPGQPAK 13 0 F8VWT9;J3KPF0;Q9Y4D8-2;Q9Y4D8-4;Q9Y4D8;A0A494C150 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 1 T(0.325)EGT(0.675)PPPPGQPAK;T(0.003)EGT(0.997)PPPPGQPAK 153.0 0.00099028 29831000.0 141322.0 108230.0 129880.0 144082.0 131665.0 99356.0 105409.0 122384.0 84806.0 112909.0 True False 133467.88899678946 116530.89298569944 121523.6622026517 124457.78304468626 115124.06559996563 113041.38713603167 110310.72736397103 122740.11717823806 101769.56967762219 109649.02379718685 1.217228246770891 1.0627627036720517 1.1082968000465638 1.1350560062886703 1.0499324263288083 1.0309383815866846 1.0060347419782607 1.1193908794415284 0.928139313541551 1.0 16.742533442223724 -1.5228787452823365 0.21408364024169077 0.9861500047084377 1.9574826128872036 0.5309437128803529 0.053373481704572755 43.30818669019561 0.5452153246718984 0.08502576397713331 14.40829991781189 0.029999999999861922 1.5228787452823365 0.9713326081787659 TEHSLHYSPT(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 TEHSLHYSPTSR 12 0 P51587 P51587 BRCA2 Breast cancer type 2 susceptibility protein 1 TEHSLHYS(0.091)PT(0.877)S(0.031)R 84.62 0.043897000000000005 4959000.0 8868.0 9675.1 18017.0 22095.0 21196.0 14803.0 13484.0 13726.0 10352.0 16521.0 True False 8375.152061416695 10417.149059650208 16857.805835426385 19085.622883999044 18533.16898535579 16841.978881745224 14111.03271803911 13765.940387538383 12422.689259047062 16043.99580328696 0.5220116088350549 0.6492864487982495 1.0507236502749957 1.1895803961809153 1.1551467111178668 1.0497371782093574 0.8795210925664889 0.8580119663655192 0.7742889870677979 1.0 13.969745873441168 -5.15835915550242 4.0648894337792365 0.9999491030746309 0.5514075039142087 0.6396862650725567 0.1239168864084488 0.15966970167136613 4.549302827708566 0.03737294240100329 0.11285309197733895 6.944497797350168e-06 5.15835915550242 -0.44854159916042224 TEIKEEEDQPSTSATQS(ph)SPAPGQSK ddPTM_A459_Selumetinib_30min_R2 4 TEIKEEEDQPSTSATQSSPAPGQSK 25 1 A0A669KB12;Q09472 A0A669KB12 EP300 Histone acetyltransferase p300 1 TEIKEEEDQPST(0.001)S(0.002)AT(0.025)QS(0.486)S(0.486)PAPGQSK;TEIKEEEDQPSTS(0.001)AT(0.022)QS(0.53)S(0.445)PAPGQS(0.003)K;TEIKEEEDQPST(0.001)S(0.002)AT(0.02)QS(0.488)S(0.488)PAPGQSK;TEIKEEEDQPSTSAT(0.017)QS(0.491)S(0.491)PAPGQSK 119.37 4.2601000000000005e-08 172467000.0 505130.0 432418.0 470461.0 451939.0 452601.0 435826.0 451423.0 455118.0 309076.0 453564.0 True False 477056.8967956044 465583.07015698415 440192.0514592077 390384.1285617397 395741.21607572265 495857.07546548 472415.06397770473 456442.3180311595 370899.83630498766 440468.4288192015 1.0830671748131608 1.0570180282957158 0.999372537639679 0.886293098482162 0.8984553493121343 1.1257494136294017 1.0725287740693359 1.0362656848182752 0.8420577095599977 1.0 18.748679090135788 -5.231483344912393 3.70838837588738 0.9852844964788133 1.0751093782752612 0.15510569984543643 0.08258649542479483 0.4821427975634013 14.371850225553 0.023494832579051824 0.06682174942345548 5.868358742000973e-06 5.231483344912393 0.08982488179644788 TEIKEEEDQPSTSATQSS(ph)PAPGQSK ddPTM_A459_Selumetinib_30min_R1 1 TEIKEEEDQPSTSATQSSPAPGQSK 25 1 A0A669KB12;Q09472 A0A669KB12 EP300 Histone acetyltransferase p300 1 TEIKEEEDQPSTSAT(0.008)QS(0.235)S(0.757)PAPGQSK 169.66 1.9009e-16 52895000.0 5522.1 5770.4 4910.0 4811.5 4156.4 4302.3 5827.2 5145.9 2702.3 5252.4 True False 5650.754185863856 5094.79888541382 4243.248968699436 3971.2618480410174 3780.454353872021 4259.022768175852 5387.649612494364 5009.414015761078 4585.605731816944 5926.596702708528 0.9534568436690473 0.8596500050501891 0.7159672205736926 0.6700745887139751 0.6378794683539554 0.7186287479675184 0.9090629720142999 0.8452429390836926 0.7737333855906318 1.0 12.53298817196371 -11.00462647541534 8.781043211668749 1.0000061166108667 0.7825763075014283 0.2945948309070797 0.09862279939103365 1.3169766318655534e-05 7.772502519673608e-07 0.10648911317325736 0.02582667741079112 9.894036873661776e-12 11.00462647541534 -0.21742980910943843 TEIMS(ph)PLYQDEAPK ddPTM_A459_Selumetinib_30min_R1 4 TEIMSPLYQDEAPK 14 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 T(0.028)EIMS(0.972)PLYQDEAPK;T(0.001)EIMS(0.999)PLYQDEAPK;T(0.011)EIMS(0.985)PLY(0.004)QDEAPK;TEIMS(1)PLYQDEAPK 201.72 5.5299e-05 232396600.0 25688.800000000003 28207.7 24254.300000000003 23107.5 23807.6 22068.6 26374.6 27191.800000000003 15563.3 24910.9 True False 26287.29905829656 24905.129370596034 20960.69927933334 19072.208906496482 21654.206783573176 21846.609920685587 24385.142687687723 26470.58513258557 26409.783401541878 28108.456667714167 0.9352096192634647 0.8860368843801543 0.7457079386151123 0.6785220950392177 0.7703804957902777 0.7772255225161103 0.8675375875651293 0.9417302929687391 0.939567181284506 1.0 14.778716622347742 -7.621421094219612 2.183293247099594 0.9635570173417763 0.7935957379364991 0.5260100123432321 0.06869006231072722 0.2895283422840466 2.753749167583506 0.047915782878735734 0.022998889192266378 2.3909963094841394e-08 7.621421094219612 -0.16996127940527728 TEIMS(ph)PLYQDEAPK ddPTM_A459_Selumetinib_30min_R2 6 TEIMSPLYQDEAPK 14 0 Q8IY81 Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 1 TEIMS(0.999)PLYQDEAPK;TEIMS(1)PLYQDEAPK;TEIMS(1)PLYQDEAPK;TEIMS(1)PLYQDEAPK;T(0.154)EIMS(0.846)PLYQDEAPK;T(0.011)EIMS(0.989)PLYQDEAPK 205.52 1.1172e-05 89418900.0 707639.0 575773.0 608789.0 683349.0 656655.0 590766.0 737449.0 705359.0 568343.0 647125.0 True False 668311.257283361 619932.9376980053 569620.1785393457 590275.6873572242 574160.1283298177 672138.654060198 771741.839727472 707411.4779115319 682027.4808302344 628440.8198173288 1.0634434241200652 0.9864619199596288 0.9064022586962434 0.9392701249559214 0.9136264071718175 1.069533729931119 1.2280262761285892 1.1256612486075583 1.085269223963653 1.0 19.26141736709215 -6.926658574870818 5.346375524397005 1.1240459799054967 0.9598587311164337 0.5236083354307013 0.06688889327123132 0.15018892218901916 7.748502914929421 0.02431453296294178 0.0213008179221223 1.183971981847177e-07 6.926658574870818 -0.164187248789063 TEKEPDATPPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TEKEPDATPPSPR 13 1 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 TEKEPDAT(0.001)PPS(0.999)PR 131.61 0.007153300000000001 5335500.0 1787.9 1268.5 1754.5 1771.8 1483.5 1601.1 1580.1 1530.5 1038.0 1373.8 True False 1829.5545913522014 1119.9834302903485 1516.248536778648 1462.3883908051687 1349.317686933197 1584.9943876824857 1460.9117848541912 1489.9061682353579 1761.4101874795504 1550.1406119452001 1.1802507316135518 0.7225044113159081 0.9781361284870651 0.9433907992192301 0.870448575139258 1.0224842672133783 0.9424382366325853 0.9611425936165514 1.1362905880320353 1.0 10.598183371745545 -8.126226053128127 6.435524989995797 1.0667973950299512 0.9435652711868849 0.14168671229125296 0.11269386760709535 0.4035453843597697 19.05803515619611 0.07215108867606713 0.026759483878863777 7.477801747079728e-09 8.126226053128127 -0.12323212384306625 TEKEPDATPPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TEKEPDATPPSPR 13 1 A0A494C0S2;A0A090HNM7;A0A1W2PS85;R4GMW8;P28715 A0A494C0S2 ERCC5-201;BIVM-ERCC5;ERCC5 DNA repair protein complementing XP-G cells 1 TEKEPDAT(0.003)PPS(0.997)PR;TEKEPDAT(0.005)PPS(0.995)PR 78.22800000000002 0.022835 24191000.0 150845.0 134093.0 162416.0 181555.0 184847.0 122708.0 131721.0 140617.0 103749.0 144227.0 True False 142461.638780379 144377.50192304765 151966.3313851703 156826.89580015597 161624.86730685335 139609.91316768178 137846.2875002098 141026.17218960245 124501.69898926505 140062.79176325057 1.0171269399026632 1.0308055416108675 1.084987165199737 1.1196899178280117 1.153945778690813 0.9967666031080239 0.9841749244382665 1.0068782037986241 0.8888991674513487 1.0 17.095714223437675 -6.931449980984273 8.005105994636509 0.973338196302323 1.0807455486244941 0.5593295023947866 0.04746143112967649 0.20984956158959017 21.509160840879073 0.01793482551074195 0.015806220155906343 1.1709814600486179e-07 6.931449980984273 0.10740735232217113 TELGSQT(ph)PESSR ddPTM_A459_Selumetinib_30min_R1 1 TELGSQTPESSR 12 0 H0YID1;F8VUX5;H0YIQ8;F8VXI8;F8VX10;Q9H9L4-4;Q9H9L4 H0YID1 KANSL2 KAT8 regulatory NSL complex subunit 2 1 TELGSQT(1)PESSR 195.94 0.00038715 5239600.0 1089.0 1240.5 1210.4 1360.3 1259.9 1250.8 1156.6 1106.9 738.22 1095.8 True False 1114.3715811748687 1095.2616833071963 1046.0343282512817 1122.749140993493 1145.942267453411 1238.2180876355333 1069.3567308159975 1077.5414162820757 1252.705422544464 1236.4566039958872 0.9012621854851408 0.8858068126027329 0.845993563276533 0.9080376435089408 0.9267953794334886 1.0014246222907892 0.8648558528945788 0.8714753213333639 1.0131414386045292 1.0 10.271995890909485 -10.525774589019486 0.09517424135462141 1.1573598722290828 0.8066237148749822 0.3374764771383 0.047636919950214386 76.86776299807397 1.4491143428324058 4.292797756671063 1.437743635582641 2.9800627640066235e-11 10.525774589019486 -0.3507361573541006 TELGSQT(ph)PESSR ddPTM_A459_Selumetinib_30min_R2 2 TELGSQTPESSR 12 0 H0YID1;F8VUX5;H0YIQ8;F8VXI8;F8VX10;Q9H9L4-4;Q9H9L4 H0YID1 KANSL2 KAT8 regulatory NSL complex subunit 2 1 TELGSQT(1)PESSR;T(0.004)ELGS(0.009)QT(0.609)PES(0.288)S(0.09)R 146.84 0.0015095999999999998 9600700.0 67051.0 56905.0 61585.0 56697.0 66567.0 52988.0 60496.0 66998.0 46711.0 57115.0 True False 63324.573846419844 61269.43052158583 57622.68814867812 48974.77079221968 58204.258343469475 60286.616022827555 63309.183870549874 67192.95308788396 56054.505214388235 55465.941547408394 1.1416839249414785 1.1046315777262525 1.0388841610022304 0.882970151157706 1.0493693376451667 1.0869123346855798 1.1414064578068621 1.2114272509094999 1.0106112625254324 1.0 15.759314546627424 -6.827078299595382 3.9102019186791903 1.1086426149609334 1.0374265781013012 0.05180022257674577 0.08512564263284966 0.5096292386365463 15.496421481614192 0.03246412360548872 0.029101700504296776 1.4890925828007024e-07 6.827078299595382 -0.07121603685963218 TELSQSDMFDQR ddPTM_A459_Selumetinib_30min_R1 2 TELSQSDMFDQR 12 0 B7Z7P8;P62495-2;P62495 B7Z7P8 ETF1 Eukaryotic peptide chain release factor subunit 1 0 ; 227.27 1.2685e-07 39849000.0 3780.6000000000004 5421.5 3969.1000000000004 4187.6 4557.2 4942.299999999999 4554.2 4348.9 2144.08 3286.6000000000004 False True 3868.680624232974 4786.7482596130285 3430.1180207056873 3456.3142709875438 4145.00206463901 4892.584949249357 4210.673027392545 4233.553044781932 3638.347162592634 3708.467124195006 1.0432020817961938 1.2907619507755739 0.9249422755635889 0.9320061780884206 1.1177130404085118 1.3193011520390348 1.1354214251815844 1.1415910949192805 0.9810919284830946 1.0 11.8566072641471 -8.26665304531306 23.86397146735651 0.9905459247168429 1.1144987883383215 0.1390891156255234 0.12193932869376085 532.2652535164171 2436204.2683436936 0.11257757030183851 0.03266686696268098 5.411865002299692e-09 8.26665304531306 0.12395286362147862 TEMDKS(ph)PFNSPS(ph)PQDSPR ddPTM_A459_Selumetinib_30min_R2 1 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 2 T(0.027)EMDKS(0.975)PFNS(0.119)PS(0.879)PQDSPR 94.456 0.0083648 14309000.0 72203.0 67827.0 76484.0 73081.0 79750.0 62082.0 70418.0 76785.0 51452.0 63549.0 True False 68190.24631150991 73029.11280182053 71563.10270948269 63127.24172824316 69731.0920259542 70633.23197571494 73692.57653061984 77008.43163755903 61743.837688996246 61714.175249868815 1.1049365244762768 1.1833442236915541 1.1595893880091155 1.0228969515132158 1.1299039765763124 1.1445220111868073 1.194094812614003 1.2478240424629627 1.0004806422350674 1.0 15.913314282438638 -8.29363581694044 23.089713377588577 1.0002399471763397 1.1465228970038441 0.528180877716055 0.0559863067372532 252.19671100219537 180858.3658806365 0.05735122393012681 0.014816091988692225 5.08585744720532e-09 8.29363581694044 0.14628294982750445 TEMDKS(ph)PFNSPSPQDSPR ddPTM_A459_Selumetinib_30min_R2 3 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 T(0.165)EMDKS(0.805)PFNS(0.02)PS(0.01)PQDSPR;T(0.017)EMDKS(0.879)PFNS(0.043)PS(0.06)PQDSPR;T(0.108)EMDKS(0.86)PFNS(0.024)PS(0.008)PQDSPR 91.14 0.0030144 93120000.0 107861.0 108040.0 109874.0 113263.0 117769.0 87836.0 114446.0 109526.0 73619.0 103871.0 True False 101866.5174217937 116326.32059664588 102804.82646176613 97836.38401042711 102973.80535178162 99934.61170417971 119767.96577044683 109844.70252699456 88344.8570867258 100871.9743407309 1.0098594588592404 1.1532075321903825 1.0191614383843262 0.9699065042580607 1.0208366201295023 0.9907074026985443 1.1873264754974262 1.0889516463309727 0.8758117174182561 1.0 16.62216587488819 -7.625073510965924 0.007090335979917211 4.775932041414365e-08 2.062472279575447 0.03959534591668312 0.08419948244416503 10094.357322661264 61.576756212433324 8906.07709613368 8998.629640721509 2.3709723484571783e-08 7.625073510965924 2.0624722318161264 TEMDKSPFNS(ph)PSPQDSPR ddPTM_A459_Selumetinib_30min_R1 1 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 TEMDKS(0.026)PFNS(0.955)PS(0.019)PQDSPR 172.56 2.2848e-07 10468000.0 3224.8 3433.5 4290.1 3863.1 3279.7 3750.9 3489.3 3929.5 1864.8 3232.7 True False 3299.931565631513 3031.504223809155 3707.5279838324723 3188.4821043681272 2983.051714078065 3713.16935154471 3226.099291748452 3825.2768951851267 3164.429400396785 3647.6485341645453 0.9046736643412183 0.8310845179889265 1.0164159044126881 0.8741198814809648 0.8178013002454199 1.017962480969996 0.8844326040549725 1.0486966766005226 0.8675258514514649 1.0 11.832751011301358 -6.770551624253597 24.999973781745986 0.9618113686321398 0.8918836679548074 0.210989581565456 0.07225633303365261 338.7524845218592 929381.1830001706 0.02434664352329169 0.021772286849773177 1.6960879775934463e-07 6.770551624253597 -0.06992770067733234 TEMDKSPFNS(ph)PSPQDSPR ddPTM_A459_Selumetinib_30min_R2 1 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 TEMDKS(0.002)PFNS(0.578)PS(0.099)PQDS(0.32)PR 72.145 0.011201 7495100.0 22302.0 26669.0 29715.0 33749.0 27391.0 19725.0 20231.0 21200.0 16347.0 29696.0 True False 21062.544121979616 28714.426545649294 27803.169251245778 29152.327979727714 23949.897701353093 22441.939704277822 21171.78158696599 21261.68849015107 19616.856773342577 28838.599320525973 0.7303594702322549 0.9956942161615908 0.964095687943373 1.0108787758973594 0.8304806150660261 0.778191043706644 0.7341473610300102 0.7372649501398632 0.6802291801800586 1.0 14.815713474696706 -6.497806712677191 4.23703351653813 0.7683494689682078 0.9331082970540927 0.2626272586427383 0.10769180268271089 0.2440258797776113 10.142230220416769 0.03419808748354083 0.03701552990177178 3.1782882865205043e-07 6.497806712677191 0.16475882808588493 TEMDKSPFNSPS(ph)PQDSPR ddPTM_A459_Selumetinib_30min_R1 4 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 TEMDKS(0.001)PFNS(0.087)PS(0.746)PQDS(0.166)PR;TEMDKSPFNS(0.081)PS(0.862)PQDS(0.057)PR;TEMDKSPFNS(0.021)PS(0.975)PQDS(0.004)PR;T(0.001)EMDKS(0.003)PFNS(0.34)PS(0.585)PQDS(0.072)PR 104.16 0.0058331 44529000.0 6845.639999999999 7831.5 10783.02 11579.8 9183.470000000001 8718.8 8114.88 7748.9400000000005 4325.572 7232.74 True False 7005.130092703329 6914.584339234426 9318.745110889075 9557.6053097673 8352.82675997332 8631.096788037003 7502.76806827263 7543.412939095517 7340.179756720893 8161.132631853639 0.8583526832245897 0.8472579298915174 1.141844585948422 1.171112606657451 1.023488667169981 1.0575856535340513 0.9193292655223673 0.9243095633139073 0.8994069926117249 1.0 12.9945536732515 -7.271923956192813 23.46783261021119 0.9294539045357498 1.0219377347890521 0.13176980354064605 0.1005910654119527 679.8553037468511 1521722.7342397976 0.04665863949222728 0.03189090228433611 5.346579683877767e-08 7.271923956192813 0.09248383025330231 TEMDKSPFNSPS(ph)PQDSPR ddPTM_A459_Selumetinib_30min_R2 2 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 TEMDKSPFNS(0.005)PS(0.989)PQDS(0.006)PR;TEMDKSPFNS(0.005)PS(0.99)PQDS(0.005)PR 112.82 0.00066467 54143000.0 142755.0 159704.0 148879.0 178202.0 166594.0 111169.0 98805.0 103007.0 78003.0 145502.0 True False 134821.24859354328 171952.783270703 139300.2872271992 153930.58018440325 145664.97235074354 126481.5206582945 103399.62827839314 103306.73331627321 93605.77958592043 141300.97920040268 0.9541423517124434 1.216925630974063 0.9858409192595476 1.089380845451102 1.0308843801015104 0.8951213316003266 0.7317686605111543 0.7311112343372834 0.6624566943245477 1.0 17.108411937862876 -6.9221791298655795 2.3566197302425986 0.7591082153416676 1.0667843552048255 0.5962661840535463 0.10597198251218737 0.1813227821096315 2.044610237135601 0.040791267080027914 0.03402272559266577 1.196247023387168e-07 6.9221791298655795 0.3076761398631579 TEMDKSPFNSPSPQDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TEMDKSPFNSPSPQDSPR 18 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 TEMDKSPFNS(0.012)PS(0.19)PQDS(0.798)PR 77.668 0.0074654 6872500.0 23805.0 28116.0 27797.0 29175.0 28505.0 20887.0 19164.0 20304.0 14435.0 26507.0 True False 22482.01339896531 30272.406792810973 26008.57128308526 25201.3146703178 24923.94706206673 23763.99465669205 20055.16397274559 20363.081278491853 17322.403347598945 25741.674036543023 0.8733702931304981 1.1760076966958752 1.0103682940807714 0.9790083828480569 0.9682333412615107 0.9231720758703009 0.7790932300780116 0.7910550514152386 0.6729322779477344 1.0 14.651818257726822 -6.941992133209766 1.611556501168092 0.7903884348400962 1.0199152984169928 0.42166768531167975 0.1035907681116446 0.31994806865271125 1.6964365853566195 0.0469764635530326 0.03695185963019646 1.1428990370227666e-07 6.941992133209766 0.22952686357689656 TEMQDNTYPEILR ddPTM_A459_Selumetinib_30min_R1 1 TEMQDNTYPEILR 13 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 178.71 0.015892 3934100.0 671.8 639.79 704.55 680.39 779.73 715.74 768.87 608.15 420.13 729.36 False True 687.4516329047536 564.8830893696982 608.8759798161275 561.5726590021045 709.2035591725127 708.5403054399239 710.873516879212 592.0198864503973 712.9299249188659 822.9804605680242 0.8353195073796429 0.6863869999778777 0.7398425709838591 0.6823645103487693 0.8617501789568828 0.8609442622135728 0.8637793373472858 0.7193608048018332 0.866278069866688 1.0 9.684714367959595 -6.272946495860435 24.829365004116166 0.8480211236218131 0.7327121666101468 0.3979068019419365 0.07473165920419308 738.8736066486097 1594293.5276479772 0.022485524328836173 0.02571026864595769 5.334006052392023e-07 6.272946495860435 -0.11530895701166632 TENNDHINLK ddPTM_A459_Selumetinib_30min_R2 2 TENNDHINLK 10 0 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 0 ; 102.53 0.021342 31134000.0 406790.0 399520.0 401250.0 452960.0 471120.0 349760.0 356540.0 353160.0 308100.0 402380.0 False True 384182.2403093934 430161.8993407254 375434.0118479679 391266.066600416 411933.69373376225 397936.26519483957 373119.81647060666 354187.63713121496 369728.60903326847 390762.2438912062 0.9831611070806401 1.1008276927094538 0.9607735079761035 1.0012893331356496 1.0541798758030738 1.0183590441906427 0.9548512485625109 0.9064018918619626 0.9461728066445595 1.0 18.575931552842512 -7.290887439107921 4.477521929218635 0.9426846761326031 1.0218067389089704 0.38117278935637167 0.041930809814203475 0.19751354444942829 9.783858956232283 0.017429736847971878 0.011934271403774383 5.118144709541271e-08 7.290887439107921 0.07912206277636735 TEPAAEAEAASGPS(ph)ESPSPPAAEELPGSHAEPPVPAQGEAPGEQAR ddPTM_A459_Selumetinib_30min_R1 2 TEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQAR 46 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 TEPAAEAEAAS(0.006)GPS(0.321)ES(0.321)PS(0.321)PPAAEELPGS(0.03)HAEPPVPAQGEAPGEQAR;TEPAAEAEAAS(0.004)GPS(0.357)ES(0.319)PS(0.319)PPAAEELPGS(0.001)HAEPPVPAQGEAPGEQAR 102.85 4.6176999999999985e-21 253890000.0 7882.2 8420.1 9350.3 9389.6 8961.0 8274.4 8533.9 8087.7 4144.4 6298.2 True False 8065.839923908681 7434.2707776017105 8080.580617521452 7749.882624621412 8150.479132193051 8191.1670485540935 7890.181052317693 7873.187923447958 7032.7441050002335 7106.6353196631735 1.1349731006446198 1.0461027537225684 1.1370473162121453 1.0905136222733216 1.146882985488462 1.1526083273036616 1.1102555143763386 1.1078643506110168 0.989602503668861 1.0 12.79495095328567 -8.244416986722008 6.001952058519026 0.9938377051715749 1.1157155617218266 0.72773065722251 0.029610481169103874 0.07749827048166098 11.512212100657901 0.022868178495027577 0.007637908115899705 5.696170932596974e-09 8.244416986722008 0.12187785655025174 TEPAAEAEAASGPSESPS(ph)PPAAEELPGSHAEPPVPAQGEAPGEQAR ddPTM_A459_Selumetinib_30min_R2 1 TEPAAEAEAASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQAR 46 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 TEPAAEAEAAS(0.011)GPS(0.04)ES(0.177)PS(0.734)PPAAEELPGS(0.037)HAEPPVPAQGEAPGEQAR 84.971 7.7222e-16 59139000.0 11301.0 10320.0 13907.0 14429.0 12739.0 11857.0 13056.0 12482.0 9205.8 11669.0 True False 10672.935661487374 11111.510815969878 13012.238760796723 12463.74530858665 11138.612931895039 13490.194122870582 13663.129869973198 12518.320553493664 11047.21723154322 11332.085650296925 0.9418333033167394 0.9805353717635139 1.148265126327895 1.0998633167108185 0.9829269982267724 1.190442301547298 1.2057030181037498 1.1046793096878558 0.9748617838282716 1.0 13.468125790613154 -5.125954560803247 5.058299311622269 1.0962591424477814 0.9509805638618579 0.2988116559269447 0.07792609306269586 0.2539857994749954 9.169703364084322 0.020609585371343515 0.05892168131994388 7.482477837983917e-06 5.125954560803247 -0.14527857858592352 TEPEGLRPAS(ph)PLALTQEQLADLK ddPTM_A459_Selumetinib_30min_R2 2 TEPEGLRPASPLALTQEQLADLK 23 1 P10070-4;P10070-2 P10070-4 GLI2 Zinc finger protein GLI2 1 TEPEGLRPAS(1)PLALTQEQLADLK;T(0.004)EPEGLRPAS(0.994)PLALT(0.002)QEQLADLK 83.395 0.00019819 15372500.0 42634.0 36342.0 43970.0 44141.0 43429.0 40995.0 46741.0 51559.0 43898.0 37841.0 True False 40264.57295742439 39129.31454205206 41141.01807091622 38128.91965252781 37973.06075981397 46641.68913444203 48914.5491155344 51709.028153948086 52678.82661260121 36748.432007274496 1.0956813871528956 1.0647886836180183 1.1195312513680094 1.037565892470733 1.033324653206892 1.2692157620550755 1.331064931038461 1.4071084214888974 1.4334986211703735 1.0 15.165395073482417 -6.86001182250021 4.479614211247611 1.3232925513356615 1.0709900694761765 0.4692445472315012 0.11399893889610942 0.16809559782664354 5.917947533547274 0.03933631925812252 0.034805687192514506 1.3803466878621894e-07 6.86001182250021 -0.252302481859485 TEPEQGTLYSPEQTS(ph)LHESEGSLGNSR ddPTM_A459_Selumetinib_30min_R2 1 TEPEQGTLYSPEQTSLHESEGSLGNSR 27 0 Q99569-2;Q99569;A0A0D9SF60;H0YFB1;E7EST6 Q99569-2 PKP4 Plakophilin-4 1 TEPEQGTLYSPEQT(0.04)S(0.957)LHES(0.002)EGS(0.001)LGNSR 134.14 3.383e-12 3420000.0 9206.4 7697.0 12306.0 17501.0 13956.0 11401.0 10427.0 10442.0 10198.0 12382.0 True False 8694.745144139231 8287.335150244204 11514.24535775973 15117.333609091073 12202.722511777 12971.38426202643 10911.876160708525 10472.384491233843 12237.884955927539 12024.499487700443 0.7230858259865923 0.6892041667697778 0.9575654578834953 1.2572110485392105 1.0148216584198666 1.0787462942049715 0.9074703002707105 0.8709206151944853 1.0177458919138682 1.0 13.553689223512295 -5.321426602940952 4.690005275566601 1.0186597485656637 0.7046762932716852 0.6118605547167039 0.09847504941482442 0.1378424590382667 6.251286614339808 0.028363664684803617 0.06372574808495676 4.7706043193849526e-06 5.321426602940952 -0.3139834552939784 TEPS(ph)SPLSDPSDIIR ddPTM_A459_Selumetinib_30min_R2 2 TEPSSPLSDPSDIIR 15 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 TEPS(0.499)S(0.499)PLS(0.001)DPSDIIR;TEPS(0.612)S(0.385)PLS(0.003)DPSDIIR 140.33 0.00038996 3907300.0 14968.1 14176.2 13142.9 15534.1 17228.1 12117.2 16573.9 18589.2 14295.5 11576.7 True False 14136.232924051783 15263.468956332585 12297.300122907545 13418.328782182818 15063.752056831854 13786.234311010157 17344.619190559806 18643.291494392266 17154.99944964329 11242.450591121122 1.257397825276285 1.3576638680882545 1.0938273664835587 1.1935412722898802 1.3398993337563483 1.2262659461361585 1.5427792232645394 1.658294278750583 1.525912816836543 1.0 13.456668923142665 -7.255854407731685 24.278115404110796 1.4866044408784291 1.245032655378008 0.18402916443590656 0.17851246927677267 385.49748945292805 1675778.6560785847 0.06676118434428599 0.050168304165113205 5.548116760673209e-08 7.255854407731685 -0.24157178550042113 TEPSS(ph)PLSDPSDIIR ddPTM_A459_Selumetinib_30min_R1 3 TEPSSPLSDPSDIIR 15 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 TEPS(0.052)S(0.948)PLSDPSDIIR;TEPS(0.205)S(0.795)PLSDPSDIIR;TEPS(0.128)S(0.872)PLSDPSDIIR 344.71 2.479799999999999e-146 37208100.0 8960.8 12519.9 7705.700000000001 8819.1 8765.800000000001 8188.4 8605.6 8370.699999999999 5029.2 8505.0 True False 9169.56920531842 11054.064287656394 6659.308264380291 7279.009740010084 7972.934937727687 8106.032130472336 7956.472663591691 8148.681844134406 8534.185081765072 9596.699595715485 0.9554919494835744 1.151861030701801 0.6939165072285254 0.7584909444555136 0.8307996783901895 0.8446687373741835 0.8290842684232729 0.8491129437637542 0.8892833412827906 1.0 13.228322618041616 -5.25577202794758 24.999959782304412 0.8285080652265491 1.0536764913591823 0.4950746562949371 0.08723081622870296 345.06437864044096 1522144.5072683934 0.021608973334860174 0.0539251611604236 5.5491692631365715e-06 5.25577202794758 0.22516842613263321 TEPSS(ph)PLSDPSDIIR ddPTM_A459_Selumetinib_30min_R2 3 TEPSSPLSDPSDIIR 15 0 Q9ULJ3;Q9ULJ3-2 Q9ULJ3 ZBTB21 Zinc finger and BTB domain-containing protein 21 1 TEPS(0.088)S(0.911)PLSDPSDIIR;TEPS(0.001)S(0.999)PLSDPSDIIR;TEPS(0.096)S(0.852)PLS(0.052)DPSDIIR 308.03 2.1035999999999992e-94 55317100.0 216502.3 197436.3 235355.0 255969.0 268896.0 204115.0 239791.0 267443.0 232336.0 221909.0 True False 204469.96889337563 212579.0293522362 220212.51553514827 221105.58062884564 235114.88051925987 232229.98847851314 250941.7566368523 268221.2148524281 278809.69201023586 215501.910581176 0.9488081490412363 0.9864368662855135 1.021858761907347 1.0260028787334525 1.0910106545468237 1.0776238032053824 1.1644525840170068 1.244634973903833 1.2937690030604758 1.0 17.71734113434872 -6.677731219424731 0.9490635416324782 1.198256917789205 0.9818365689054168 0.5178375121536325 0.07556439419460506 0.4078391531706589 0.7975806945927013 0.04253429317254017 0.042617728716586235 2.1002392988905114e-07 6.677731219424731 -0.21642034888378825 TEPTS(ph)PTPSAFK ddPTM_A459_Selumetinib_30min_R1 2 TEPTSPTPSAFK 12 0 Q86XN7-2;Q86XN7 Q86XN7-2 PROSER1 Proline and serine-rich protein 1 1 TEPTS(0.909)PT(0.087)PS(0.004)AFK;TEPT(0.011)S(0.906)PT(0.073)PS(0.011)AFK 176.32 0.00010353 42857000.0 7677.9 9700.1 7995.1 9028.8 8366.1 8452.0 8429.5 8174.900000000001 4791.8 8364.0 True False 7856.780131407273 8564.407782545859 6909.409333940705 7452.089571566602 7609.387732154922 8366.980553801992 7793.656028370617 7958.075096182436 8131.334620775053 9437.600872259176 0.832497605880054 0.9074772178298008 0.7321150181557454 0.7896169452843917 0.8062841219024114 0.8865579999675385 0.8258090306911834 0.8432307324602327 0.8615891613594558 1.0 13.204204444080448 -9.618714441385958 0.49945817318978303 1.0200051167175421 0.8194119915958724 0.5685446963206142 0.04533894941476454 3.812827874782862 1.0998025388458121 0.19567700525530843 0.023893329282101746 2.4059442437280437e-10 9.618714441385958 -0.2005931251216697 TEPTSPTPS(ph)AFK ddPTM_A459_Selumetinib_30min_R2 2 TEPTSPTPSAFK 12 0 Q86XN7-2;Q86XN7 Q86XN7-2 PROSER1 Proline and serine-rich protein 1 1 TEPT(0.001)S(0.031)PT(0.223)PS(0.745)AFK;TEPTS(0.147)PT(0.195)PS(0.658)AFK 121.21 0.0028026 17940000.0 339520.0 306470.0 341150.0 407660.0 377060.0 287550.0 310120.0 320770.0 288020.0 361930.0 True False 320650.8376062469 329975.26354363293 319200.7804160348 352136.00474727503 329690.3518408306 327157.40238099324 324541.19449112186 321703.3875936679 345632.0479511918 351480.14049292693 0.9122872124625759 0.9388162388943657 0.9081616388578242 1.0018660065784322 0.9380056334860409 0.9307991112162903 0.923355709474723 0.9152818339679187 0.9833615278133963 1.0 18.42308365015913 -8.409016220200021 4.7443363497957 0.9992038137900253 0.9350337492750511 0.4654987981245666 0.025111453208046693 0.19382656436007073 6.2363916020322625 0.02458590690296854 0.0064173448979459565 3.899274232428079e-09 8.409016220200021 -0.0641700645149742 TEQELPRPQS(ph)PSDLDSLDGR ddPTM_A459_Selumetinib_30min_R1 2 TEQELPRPQSPSDLDSLDGR 20 1 P54259 P54259 ATN1 Atrophin-1 1 TEQELPRPQS(0.736)PS(0.262)DLDS(0.001)LDGR;TEQELPRPQS(0.993)PS(0.006)DLDSLDGR 110.13 0.00021061 20148600.0 3452.44 3612.75 4375.9 4327.7 4205.3 3879.3 4541.6 3583.06 2267.23 3112.5499999999997 True False 3532.8751347211796 3189.7675504780905 3781.676815098135 3571.9484359902513 3824.931357506018 3840.2777641225803 4199.023455536864 3488.025609380841 3847.3237180725014 3512.076111304437 1.0059221448390017 0.9082284806445621 1.0767639126401405 1.0170475589902797 1.0890798594012765 1.093449470460435 1.1955958021585373 0.9931520556043237 1.0954556781070295 1.0 11.778108394971476 -5.27628547172698 24.351138272197847 1.0739270707971769 0.9570753173371744 0.3614195368062374 0.05990213888474285 502.41725535441464 824084.5186363503 0.015469087722249095 0.03242772271994255 5.293153983596e-06 5.27628547172698 -0.11685175346000243 TEQELPRPQS(ph)PSDLDSLDGR ddPTM_A459_Selumetinib_30min_R2 3 TEQELPRPQSPSDLDSLDGR 20 1 P54259 P54259 ATN1 Atrophin-1 1 T(0.002)EQELPRPQS(0.498)PS(0.498)DLDS(0.002)LDGR;TEQELPRPQS(0.979)PS(0.021)DLDSLDGR;TEQELPRPQS(0.819)PS(0.18)DLDS(0.001)LDGR 136.11 5.795e-05 46266000.0 43813.0 47051.0 50819.0 57315.0 61032.0 41839.0 39803.0 42701.0 45357.0 49114.0 True False 41378.04885733534 50659.660407189804 47549.360867543604 49508.59812611021 53364.6145269973 47601.94247337288 41653.91836814823 42825.252840468915 54429.667380467305 47695.951206502956 0.8675379735731905 1.062137542615625 0.996926566401314 1.0380042094508037 1.118849989927897 0.9980289997211071 0.8733218924139846 0.8978802551825413 1.141180037374876 1.0 15.541579184098595 -9.788374835745412 15.322928897127348 0.999997111926321 0.9990221134028615 0.0 0.0913205531222607 0.0 0.0 0.08982813121928804 0.021786521951115762 1.6278904082505122e-10 9.788374835745412 -0.0009749985234595027 TEQELPRPQSPS(ph)DLDSLDGR ddPTM_A459_Selumetinib_30min_R1 1 TEQELPRPQSPSDLDSLDGR 20 1 P54259 P54259 ATN1 Atrophin-1 1 TEQELPRPQS(0.466)PS(0.533)DLDS(0.001)LDGR 108.34 0.00023439 15813000.0 2022.8 2471.2 2677.3 3059.6 2545.0 2432.4 2479.6 2246.7 1198.0 1458.7 True False 2069.9273043163676 2181.870755170288 2313.737365356211 2525.2982958051107 2314.8051993562435 2407.9322644424938 2292.5617756625857 2187.1102176898917 2032.9185015419075 1645.9383539412327 1.2575971022000214 1.3256090362957726 1.4057254087408073 1.5342605570604955 1.4063741778745211 1.4629541007271938 1.3928600485996332 1.3287923040694762 1.2351121757835237 1.0 10.684694587536606 -8.583479390620962 1.306743199456163 1.0016243525576547 1.403784116839222 0.7525617753165476 0.06996683509642296 0.2733104184618948 1.0111426204873277 0.0728162499145977 0.02211821426069839 2.6092795430427623e-09 8.583479390620962 0.4021597642815673 TEQGDSAVYLCAS(ph)SL ddPTM_A459_Selumetinib_30min_R1 1 TEQGDSAVYLCASSL 15 0 A0A1B0GX95 A0A1B0GX95 1 TEQGDS(0.026)AVYLCAS(0.967)S(0.007)L 93.348 0.012566 29864000.0 2926.3 2680.4 2206.1 2521.0 979.94 2759.8 2109.9 1224.9 1220.4 1190.3 True False 2994.4770964114023 2366.5775219158477 1906.523737239883 2080.7546750309466 891.3046000224588 2732.0389176979093 1950.7485443097642 1192.4116729640568 2070.929665510638 1343.0865995038375 2.2295487852515397 1.7620438792182929 1.419509164892413 1.5492334416854565 0.6636240733484529 2.0341494872387065 1.452436905431421 0.8878144368386648 1.5419181952047472 1.0 10.391336614480913 -4.6919752117219335 1.1355281566877187 1.3052450957019865 2.820893720939873 0.3919250901226402 0.36594644730780185 2.05490514233559 1.9410209059718548 0.11235040627322943 3.9145534489415468 2.0324730153308838e-05 4.6919752117219335 1.5156486252378865 TES(ph)GEETDLISPPQEEVK ddPTM_A459_Selumetinib_30min_R1 3 TESGEETDLISPPQEEVK 18 0 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 T(0.02)ES(0.98)GEETDLISPPQEEVK;T(0.05)ES(0.95)GEETDLISPPQEEVK;T(0.307)ES(0.693)GEETDLISPPQEEVK 284.07 2.3225999999999994e-67 50876000.0 9233.3 9420.0 8429.6 5880.9 7019.799999999999 8911.9 7866.2 10542.5 5352.2 8054.2 True False 9448.417925125726 8317.10202076081 7284.90662047836 4853.911213165214 6384.860329446354 8822.254377357778 7272.8462008860515 10262.878653133786 9082.292490778467 9088.035024551635 1.0396546557754789 0.9151705509817994 0.8015931497620705 0.5340990874322346 0.70255674765749 0.9707548830439318 0.8002660840586784 1.1292736686652585 0.999368121518276 1.0 13.14975267954535 -7.751396279148393 24.985285136393866 1.0482406732538623 0.8160176572830804 0.3488387597251814 0.13706864032237354 229.4785606092942 570901.5441916016 0.07187342758402993 0.04087238077097427 1.7725713308616908e-08 7.751396279148393 -0.23222301597078188 TES(ph)GEETDLISPPQEEVK ddPTM_A459_Selumetinib_30min_R2 3 TESGEETDLISPPQEEVK 18 0 A0A5F9UY30;A0A5H1ZRP2;O43493;O43493-5;O43493-3;O43493-7 A0A5F9UY30 TGOLN2 Trans-Golgi network integral membrane protein 2 1 T(0.037)ES(0.962)GEET(0.001)DLISPPQEEVK;T(0.131)ES(0.868)GEET(0.001)DLISPPQEEVK;T(0.107)ES(0.893)GEETDLISPPQEEVK 165.16 4.789e-07 27135500.0 59031.0 22519.6 39563.0 39634.0 33440.2 34134.1 52550.0 40660.0 32853.3 27266.7 True False 55750.29333981611 24246.780908073197 37017.55965293742 34235.780827536444 29239.14311681896 38835.76243649124 54993.67912584954 40778.31386837465 39424.87799789902 26479.43952360536 2.105418178889963 0.9156833129514755 1.3979736852034859 1.292919391175807 1.1042206195774436 1.4666383856754488 2.07684452976525 1.5399991314779309 1.48888642309643 1.0 14.69258496524924 -6.999751166563469 24.999811126077212 1.6000480178683845 1.3313040290124816 0.022685857087378136 0.3785278987594785 20.95073115995995 2104630.590236288 0.12835962465519762 0.11212545915566718 1.0005731243346224e-07 6.999751166563469 -0.2687439888559029 TES(ph)LEGDDESK ddPTM_A459_Selumetinib_30min_R2 2 TESLEGDDESK 11 0 Q5T200 Q5T200 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 TES(1)LEGDDESK;T(0.051)ES(0.949)LEGDDESK 143.42 0.0008404 11536400.0 66471.0 59102.0 63700.0 66766.0 64054.0 61686.0 86595.0 87011.0 68176.0 60514.0 True False 62776.807924495806 63634.93335711747 59601.611351316016 57672.355622225805 56006.96386997451 70182.68657024493 90621.83908473715 87264.18760455347 81813.1049965989 58766.80358574579 1.0682358762783326 1.0828380901178105 1.0142054308662913 0.9813764251798537 0.9530374369988588 1.1942573406743553 1.5420583314951297 1.4849231586541467 1.3921653042984818 1.0 15.842713809671192 -7.008368092000582 4.8152029863566845 1.3942938273077283 1.0233826355887992 0.5501830236715264 0.14089302625310574 0.12559475046076718 8.017941597579822 0.05102679633515433 0.0418910595779355 9.809162021638058e-08 7.008368092000582 -0.37091119171892917 TES(ph)PATAAETASEELDNR ddPTM_A459_Selumetinib_30min_R1 7 TESPATAAETASEELDNR 18 0 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64 C9JR83 SMC4 Structural maintenance of chromosomes protein 4 1 T(0.059)ES(0.94)PAT(0.001)AAETASEELDNR;T(0.01)ES(0.99)PAT(0.001)AAETASEELDNR;T(0.022)ES(0.973)PAT(0.005)AAETASEELDNR;T(0.144)ES(0.856)PATAAETASEELDNR;T(0.001)ES(0.924)PAT(0.075)AAETASEELDNR;TES(0.999)PATAAETASEELDNR;T(0.002)ES(0.998)PATAAETASEELDNR 263.07 7.256e-43 998777000.0 15006.93 18126.05 16344.869999999999 16805.649999999998 15930.43 15216.69 15881.18 15241.55 9168.64 13699.7 True False 15356.562270597402 16003.843639427969 14125.326429944265 13870.858708621116 14489.525419245845 15063.62391424908 14683.249806588621 14837.294582468225 15558.512429029382 15458.189941378414 0.9934256422539501 1.0352986798660657 0.9137762237047984 0.8973145472544404 0.9373364846850761 0.9744752763017123 0.9498686367725735 0.9598338899143567 1.0064899246309833 1.0 13.91608377801801 -8.23935881487698 6.323295643134166 1.0034799966049706 0.9562915629066115 0.1950207391459542 0.036971517598593615 0.28015553353484596 46.363539303757214 0.0305486916034897 0.01047540661389153 5.762901347084855e-09 8.23935881487698 -0.04718843369835901 TES(ph)PATAAETASEELDNR ddPTM_A459_Selumetinib_30min_R2 4 TESPATAAETASEELDNR 18 0 C9JR83;Q9NTJ3-2;Q9NTJ3;C9JWF0;C9IYK2;C9JJ64 C9JR83 SMC4 Structural maintenance of chromosomes protein 4 1 T(0.004)ES(0.988)PAT(0.008)AAETASEELDNR;TES(0.998)PAT(0.002)AAETASEELDNR;T(0.466)ES(0.534)PATAAETASEELDNR;T(0.001)ES(0.999)PATAAETASEELDNR 352.64 8.144899999999995e-184 516754000.0 456539.0 396251.0 489432.0 461420.0 532737.0 405614.0 462781.0 434078.0 378979.5 446697.0 True False 431166.39005041897 426642.1775522163 457942.477973271 398573.8000061031 465809.8153307928 461483.6467027092 484301.23348315497 435341.09511451854 454785.98957196815 433799.69695181155 0.9939296709520636 0.9835004047953718 1.0556542136638267 0.9187968613320135 1.07379008930598 1.0638173561333144 1.116416716946101 1.0035532485926983 1.0483778406661448 1.0 18.72666951959483 -6.309011725980909 24.981115382162404 1.0550826644876068 0.9924853905390316 0.3249375774452796 0.04407447123609069 469.5798737761629 246583.89693150384 0.01335977007493615 0.015148594832936554 4.908946217850871e-07 6.309011725980909 -0.06259727394857517 TES(ph)VPSDINNPVDR ddPTM_A459_Selumetinib_30min_R1 2 TESVPSDINNPVDR 14 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 T(0.047)ES(0.951)VPS(0.003)DINNPVDR;T(0.003)ES(0.99)VPS(0.007)DINNPVDR 207.08 7.0703e-06 70968000.0 7685.2 8080.3 8471.1 9295.0 8609.2 7269.599999999999 8841.1 8457.8 4784.9 7591.0 True False 7864.250207203945 7134.254719570447 7320.771148421548 7671.802738759478 7830.499380077713 7196.47442426869 8174.208708989554 8233.471669193726 8119.625824731114 8565.378792601558 0.9181438903784127 0.8329175967947547 0.8546932162235424 0.8956758275986678 0.9142035127321392 0.8401816893941371 0.9543312569025107 0.961250152334825 0.9479587559798911 1.0 13.064301333671173 -7.352008725630663 6.242582941352116 0.9639506869732025 0.8758123265190709 0.687701991586632 0.029707575945127237 0.14699110821455094 8.361719545929958 0.012609727636214358 0.008436730487620456 4.446223342465867e-08 7.352008725630663 -0.08813836045413159 TES(ph)VPSDINNPVDR ddPTM_A459_Selumetinib_30min_R2 1 TESVPSDINNPVDR 14 0 A0A2R8Y4X0;A0A0A0MQW1;A0A2R8Y5H9;Q8IVT5-4;Q8IVT5-3;Q8IVT5-2;Q8IVT5;A8MY87 A0A2R8Y4X0;A8MY87 KSR1 Kinase suppressor of Ras 1 1 T(0.031)ES(0.957)VPS(0.012)DINNPVDR 207.4 6.8142999999999984e-06 44421000.0 45170.0 30876.0 40079.0 41169.0 40534.0 29814.0 34781.0 35273.0 32046.0 34899.0 True False 42659.63222983676 33244.08991801222 37500.36077471576 35561.711179513775 35441.7565414423 33920.60787545444 36398.385417244026 35375.6385902405 38456.095440052355 33891.37519150847 1.258716472517916 0.9809011800247507 1.1064868440071893 1.0492849870672645 1.0457456016810518 1.000862540507158 1.073971923876482 1.043794723298921 1.134686781600045 1.0 15.048630556994476 -4.749272595347068 24.999963256444836 1.0508547014158387 1.258716945808511 0.6574132378757515 0.04551318135733381 336.50199724688804 691392.7236624862 0.010687144231593943 0.17771738293649597 1.78126036570122e-05 4.749272595347068 0.2078622443926723 TESGYGSESS(ph)LRR ddPTM_A459_Selumetinib_30min_R2 1 TESGYGSESSLRR 13 1 A0A2U3TZL3;Q9Y5P4;Q9Y5P4-3;A0A2R8YCI0;A0A2R8YFI2;A0A2R8YEA4;A0A2R8Y5H3;A0A2R8Y7Q9;A0A2R8YEK8;A0A2R8YE18;A0A2R8Y5S9;A0A2R8Y7C5;Q9Y5P4-2 A0A2U3TZL3 COL4A3BP Collagen type IV alpha-3-binding protein 1 TESGYGS(0.011)ES(0.434)S(0.554)LRR 81.44800000000002 0.017987 12348000.0 45757.0 33361.0 38767.0 49757.0 42292.0 30211.0 35631.0 37699.0 34583.0 30957.0 True False 43214.0091197839 35919.681427477815 36272.773426318185 42980.01076438744 36978.900864722906 34372.29102184726 37287.91210148708 37808.69784859457 41500.56632975507 30063.190974054505 1.437439197890835 1.1948060157179472 1.206551009758836 1.4296556477148605 1.2300391164942164 1.1433347528381683 1.24031784030071 1.2576408765531473 1.380444489926947 1.0 14.875710527796311 -6.490109554147119 24.875056860006342 1.2186969879002167 1.3041504689607302 0.16545800116092746 0.1168988794518249 1428.283837378497 1084209.3529442595 0.03576861441022563 0.040529524848285314 3.235120382180101e-07 6.490109554147119 0.08545348106051343 TESIT(ph)ATSPASMVGGKPGSFR ddPTM_A459_Selumetinib_30min_R1 2 TESITATSPASMVGGKPGSFR 21 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 T(0.012)ES(0.077)IT(0.45)AT(0.385)S(0.076)PASMVGGKPGSFR;TES(0.013)IT(0.805)AT(0.112)S(0.069)PASMVGGKPGSFR 160.45 1.3845e-07 90503000.0 3956.2 4469.4 5221.0 4993.7 4869.5 3974.4 4122.8 4074.7 2513.56 3696.7 True False 4048.3717625748536 3946.1205702323105 4512.016876900153 4121.644038358604 4429.054584780053 3934.421144466472 3811.8138767146756 3966.625719509057 4265.327736841134 4171.207453907281 0.9705515267006526 0.9460379551575346 1.0817052200732973 0.9881177294353343 1.0618159450763447 0.943233149619781 0.9138394383007846 0.9509538337138838 1.0225642776040036 1.0 12.026249350732549 -6.79445616238435 24.984965976628068 0.9597853234460838 1.008919307544618 0.17101155660269596 0.04687869894323987 319.3312829451572 241646.90419458644 0.016887618939356527 0.014894577844879834 1.6052542840304017e-07 6.79445616238435 0.04913398409853409 TESITATS(ph)PASMVGGKPGSFR ddPTM_A459_Selumetinib_30min_R2 3 TESITATSPASMVGGKPGSFR 21 1 P35568 P35568 IRS1 Insulin receptor substrate 1 1 TES(0.001)IT(0.013)AT(0.08)S(0.906)PAS(0.001)MVGGKPGSFR;TES(0.002)IT(0.071)AT(0.219)S(0.701)PAS(0.007)MVGGKPGSFR;T(0.001)ES(0.001)IT(0.019)AT(0.087)S(0.886)PAS(0.005)MVGGKPGSFR 101.16 0.00013791 65234100.0 116774.0 100738.0 127385.0 129104.0 134537.0 89298.0 95834.0 115137.0 93602.0 102284.0 True False 110284.16856335972 108464.28067627642 119189.18778630128 111519.81248317791 117635.25928395973 101597.98893346518 100290.47089146847 115472.0296080436 112325.0154583965 99330.79515425212 1.1102716775003962 1.091950190349738 1.1999218127793179 1.1227113636812964 1.1842778375153684 1.0228246816678785 1.0096614120094989 1.16249980108108 1.1308176410343387 1.0 16.599953439988752 -6.758443634851532 24.999998239582787 1.0718482404849288 1.1412212194872156 0.31032532528830736 0.05670585985424185 118.071893637926 985328.7940968665 0.020107175803603758 0.01928136195191454 1.744039693929911e-07 6.758443634851532 0.06937297900228678 TESSPSEASQHSMQS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 4 TESSPSEASQHSMQSPQK 18 0 Q9UQR0 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 TESSPSEASQHS(0.01)MQS(0.99)PQK;TESSPSEASQHS(0.066)MQS(0.934)PQK;TESSPSEASQHS(0.018)MQS(0.982)PQK;TESSPSEASQHSMQS(1)PQK 150.63 9.2509e-05 50707100.0 8126.0 8265.3 7437.200000000001 8211.7 11495.7 8128.9 10048.1 7138.900000000001 1739.73 4256.549999999999 True False 8315.319989556461 7297.594833566275 6427.269089615365 6777.680747699968 10455.915964730673 8047.130646450661 9290.163727228279 6949.553181584709 2952.194745148165 4802.91965480808 1.7313052449736916 1.5194080596915336 1.3382004179855873 1.4111584691855101 2.1769916459592498 1.675466429756926 1.9342742321179855 1.4469434596157962 0.6146666938708414 1.0 12.229695959450309 -8.118853323800952 4.542237621218672 0.8211133206918705 1.673604869523872 0.6600930810485239 0.24735131936974447 0.14357248955038202 4.556638771503721 0.19023851703239353 0.06750372359547663 7.605831086695186e-09 8.118853323800952 0.8524915488320016 TESSPSEASQHSMQS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 4 TESSPSEASQHSMQSPQK 18 0 Q9UQR0 Q9UQR0 SCML2 Sex comb on midleg-like protein 2 1 TESSPSEASQHS(0.048)MQS(0.952)PQK;TESSPSEASQHS(0.012)MQS(0.988)PQK;TESSPSEASQHS(0.02)MQS(0.98)PQK;TESSPSEASQHSMQS(1)PQK 149.31 0.00011434 92743400.0 77749.0 65119.7 111053.0 147914.0 175145.0 111777.0 90452.0 95345.0 97992.0 150171.0 True False 73428.02183390685 70114.17159716228 103907.97088536435 127767.85803411815 153141.71928383355 127173.26713941999 94658.19722723766 95622.43816478565 117593.13812524511 145835.17303888404 0.5035000837166267 0.4807768258928025 0.7125028120456193 0.8761114028373073 1.0501013993585853 0.8720342595644727 0.649076592805214 0.6556884472533236 0.8063427750306248 1.0 17.15397919032234 -5.409493805416869 3.152762885848942 0.8304545290865245 0.48951825651080616 0.5685109468719978 0.12096817948559103 0.20991905690861187 3.899572705967886 0.037122097348994756 0.08807751054419832 3.894988633024049e-06 5.409493805416869 -0.34093627257571835 TESVTSGPMSPEGSPSKSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 TESVTSGPMSPEGSPSKSPSK 21 1 P35612 P35612 ADD2 Beta-adducin 1 TESVTS(0.001)GPMS(0.008)PEGS(0.018)PS(0.322)KS(0.275)PS(0.377)K 71.002 0.0031536 25958000.0 3534.4 4763.1 3852.8 3413.1 3082.3 3228.3 3660.2 3697.4 2757.3 3985.8 True False 3616.7446432547786 4205.434037694884 3329.610921915516 2817.066156821947 2803.506509224264 3195.826233061876 3384.108167156072 3599.3329411521777 4678.936714775877 4497.416254979753 0.8041827658825547 0.9350777867266405 0.7403386151390395 0.6263743440920679 0.6233593579691648 0.7105916045736939 0.7524560715075076 0.8003112758724135 1.0403610538818007 1.0 12.134880702403377 -8.166006102546477 3.393015511820127 1.0237210766607123 0.7403859712187143 0.6267726736250736 0.08445102920315571 0.18332178908477398 3.769400278428138 0.07962749083109395 0.02556359041140971 6.8232910623642916e-09 8.166006102546477 -0.283335105441998 TESVTSGPMSPEGSPSKSPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 TESVTSGPMSPEGSPSKSPSK 21 1 P35612 P35612 ADD2 Beta-adducin 1 TESVTSGPMS(0.001)PEGS(0.043)PS(0.146)KS(0.328)PS(0.483)K 81.525 0.0009662 20903000.0 16276.0 14182.0 15096.0 18489.0 20096.0 14276.0 19109.0 20330.0 15055.0 18924.0 True False 15371.445077990322 15269.713797682649 14124.739795282056 15970.76630469601 17571.360819480567 16242.389415374919 19997.606363765164 20389.156934187326 18066.420671846365 18377.61494954315 0.8364221973413608 0.8308865889075687 0.768583944873281 0.8690336775770258 0.9561284675799225 0.8838137843223606 1.0881502533745429 1.10945609591707 0.9830666667817785 1.0 14.1656619250808 -6.702162084876302 1.115682987815877 1.050645550440686 0.8161746609536583 0.7367483467447775 0.05526880232936293 0.2415723760837012 0.6404635369682627 0.029130582880568065 0.027894972203756568 1.9853538167952348e-07 6.702162084876302 -0.23447088948702766 TET(ph)PPPLASLNVSK ddPTM_A459_Selumetinib_30min_R1 1 TETPPPLASLNVSK 14 0 K7ELG9;Q3MHD2;Q3MHD2-2 K7ELG9 LSM12 Protein LSM12 homolog 1 T(0.4)ET(0.6)PPPLASLNVSK 125.39 0.0032355 99929000.0 1962.5 2558.3 1504.7 1791.0 1514.7 1589.5 1795.0 2135.3 1441.7 2173.8 True False 2008.2224316397421 2258.773046678596 1300.3700047254656 1478.2354712338072 1377.695652442006 1573.5110731505285 1659.6017048372084 2078.6649075680884 2446.459602398138 2452.828404605092 0.8187374330260448 0.9208850657623809 0.5301512336876361 0.6026656689308051 0.5616763283788767 0.6415088271957065 0.6766073410277577 0.847456309485602 0.9974034864424283 1.0 11.26023059377795 -7.986394603867009 2.41289367583801 1.000447212140299 0.6723313499713405 0.5771860580640211 0.11051304133964202 0.24345732617773158 2.672940341276176 0.09727080792131146 0.034058079917605545 1.0318234556515298e-08 7.986394603867009 -0.3281158621689585 TET(ph)QEKNPLPSK ddPTM_A459_Selumetinib_30min_R1 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 T(0.072)ET(0.928)QEKNPLPSK 127.66 0.022057 0.0 988.87 1145.0 784.62 1259.5 894.74 1122.5 1036.2 951.48 618.32 820.34 True False 1011.9087469939326 1010.9428677039419 678.0729136091546 1039.551968743149 813.8109249791773 1111.2086691484544 958.0385997505944 926.2436595573851 1049.243879693984 925.6386297882699 1.0932006448622353 1.0921571714602971 0.7325460409579673 1.1230645905313348 0.8791885934636587 1.2004778467409378 1.0350028282308568 1.0006536349603878 1.1335351031470968 1.0 9.854305263642164 -6.751546173132474 24.99999074504431 1.0715415577611205 0.9837910850203798 0.11918012988381665 0.12211580958373527 483.38866975770105 1221514.463268665 0.03973917426920023 0.03927440950931596 1.7719596446827414e-07 6.751546173132474 -0.08775047274074066 TET(ph)QEKNPLPSK ddPTM_A459_Selumetinib_30min_R2 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 T(0.006)ET(0.991)QEKNPLPS(0.003)K 149.35 0.0059957 5337000.0 24022.0 20325.0 24084.0 22214.0 17429.0 11106.0 24207.0 23634.0 16261.0 15301.0 True False 22686.953407685145 21883.8621448244 22534.461660676523 19188.414878712596 15239.413202763062 12635.750689769802 25332.673465260526 23702.771027180665 19513.654370301796 14859.220373227621 1.52679298360505 1.472746321486242 1.5165305510427487 1.2913473517954575 1.0255863241802678 0.8503643106697628 1.7048453976026423 1.59515576401887 1.3132354107527897 1.0 13.859070802748668 -11.783673483839648 1.6868909229348352 8.886522013409548e-05 1.3631294304469201 0.16347424701668456 0.24848439063335181 1865565.878320775 271092.39119560446 7083051.141149431 0.07279484842236485 1.6456084781095171e-12 11.783673483839648 1.363040565226786 TET(ph)QEKNTLPTK ddPTM_A459_Selumetinib_30min_R1 1 TETQEKNTLPTK 12 1 P63313;CON__P21752 P63313 TMSB10 Thymosin beta-10 1 T(0.08)ET(0.92)QEKNTLPTK 161.49 0.0050017 4748500.0 1239.6 1073.8 1543.1 2061.2 1072.3 1309.9 847.37 1245.5 597.6 841.43 True False 1268.4802681582794 948.0789968039235 1333.555495641568 1701.2501135159805 975.3106543299409 1296.7235952940398 783.4521986784996 1212.4652940458266 1014.0835530229077 949.4357367222673 1.3360359412396337 0.9985710039491165 1.4045768913706531 1.791853885118332 1.0272529425709227 1.3657834281346022 0.8251766479564042 1.2770377679605942 1.0680907762370773 1.0 9.890926543546362 -6.836651777926433 1.955701035267411 1.0770944679571226 1.342219866691755 0.22016648653625237 0.23555030335210073 0.5713987490134671 4.491267347053785 0.10017364220643706 0.08715134757672052 1.4566265516012508e-07 6.836651777926433 0.2651253987346325 TETQEKNPLPS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 T(0.001)ET(0.055)QEKNPLPS(0.945)K 132.14 0.00914 10162000.0 2008.2 2084.3 1411.3 1826.9 1340.8 1965.2 2063.2 2127.8 802.43 1883.9 True False 2054.9871527230216 1840.2691870352191 1219.653211715991 1507.8662101602679 1219.5248767374671 1945.4318722588343 1907.571162908151 2071.3638319315223 1361.665102831614 2125.7169157399658 0.9667266311458396 0.865716960432908 0.5737608816512746 0.7093447857497888 0.5737005090882237 0.9151885925420253 0.8973777970074261 0.9744307045750149 0.6405674682028938 1.0 11.053733768901406 -6.806969466924251 24.99960504454596 0.8846565486292199 0.734253314401049 0.20942476878844118 0.14335939425427627 217.0635838374217 119183.47774007061 0.05200874036597964 0.045867571172039164 1.5596621510279247e-07 6.806969466924251 -0.15040323422817092 TETQEKNPLPSK ddPTM_A459_Selumetinib_30min_R2 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 109.16 0.021859 18405000.0 150330.0 132060.0 157550.0 141170.0 159250.0 88583.0 106030.0 100430.0 79105.0 136090.0 False True 141975.26041867075 142188.57736017276 147413.40452746983 121942.40246816675 139243.5912869366 100784.50417358888 110960.60509445923 100722.2346729185 94928.21037837307 132160.72809571607 1.0742620933190274 1.0758761654006181 1.115410051469353 0.9226825867654966 1.0535927979005295 0.7625904126420726 0.8395883307641672 0.7621192477085283 0.7182785063776456 1.0 17.01193401437873 -6.756623683380877 24.999870964968597 0.8030898041052955 1.0466355878865476 0.6483883092486173 0.08507552144701773 71.67889790107671 372108.70881157846 0.027816244438083833 0.026969323301672454 1.751363589698977e-07 6.756623683380877 0.24354578378125213 TEVS(ph)PVPR ddPTM_A459_Selumetinib_30min_R1 2 TEVSPVPR 8 0 E9PPY3;O43159 E9PPY3 RRP8 Ribosomal RNA-processing protein 8 1 TEVS(1)PVPR;TEVS(1)PVPR 103.88 0.015058000000000004 182789000.0 13690.5 15196.3 12622.099999999999 13586.2 14175.2 11952.9 13901.8 13439.5 7431.4 12399.5 True False 14009.462012924285 13417.11013143179 10908.088148232413 11213.625214559881 12893.055662834828 11832.664678364858 12853.176033596608 13083.040802351572 12610.543032018802 13991.096606357933 1.0013126495429963 0.9589748758746109 0.7796449738811383 0.8014829380467652 0.9215185932585066 0.8457281806622488 0.918668235608907 0.9350975960244806 0.9013262781909626 1.0 13.772221423292459 -8.797776231793177 0.7219137519251304 0.9991085660569875 0.883574881187361 0.19174380696573667 0.06515172855186958 1.9283102701185144 2.0039360877842944 0.07212530200232324 0.026201140680445913 1.5930293165581214e-09 8.797776231793177 -0.11553368486962645 TEVS(ph)PVPR ddPTM_A459_Selumetinib_30min_R2 1 TEVSPVPR 8 0 E9PPY3;O43159 E9PPY3 RRP8 Ribosomal RNA-processing protein 8 1 T(0.002)EVS(0.998)PVPR 83.647 0.038396 106420000.0 235120.0 202810.0 239500.0 257450.0 283000.0 220970.0 231840.0 221820.0 200390.0 205910.0 True False 222052.97165993374 218364.87486306683 224090.8307478835 222384.86587397804 247447.00994789993 251406.61173405687 242621.0193822447 222465.45947572216 240473.59936441632 199964.84328156983 1.1104600589577722 1.0920163328690133 1.1206511458233783 1.112119821787066 1.237452573598003 1.2572540633057785 1.2133183783741968 1.1125228606434046 1.2025793905471986 1.0 17.609386850027988 -6.148356296045551 8.666185950756516 1.182564335792874 1.1079186564611636 0.14554998373113193 0.0697134230957352 0.520554014189699 36.556159690481344 0.020150458649317894 0.026058063389537325 7.106302719695125e-07 6.148356296045551 -0.07464567933171029 TEVSETARPS(ph)SPDTR ddPTM_A459_Selumetinib_30min_R1 1 TEVSETARPSSPDTR 15 1 O75132 O75132 ZBED4 Zinc finger BED domain-containing protein 4 1 TEVSET(0.026)ARPS(0.487)S(0.487)PDTR 220.52 9.7508e-09 12474000.0 2961.0 3142.3 3039.1 2260.2 3195.8 2451.2 3152.6 2740.6 1688.3 2624.5 True False 3029.9855388969563 2774.3980551843615 2626.406912581355 1865.4984992086258 2906.740454264316 2426.5431535115295 2914.7968438271796 2667.9103852765884 2864.921791446748 2961.3801397948587 1.023166697912295 0.9368598167800741 0.8868861100565401 0.62994226041438 0.9815492496906096 0.8193960379837022 0.9842697344587088 0.9009010188949942 0.9674279073287794 1.0 11.532053979701645 -7.273988958494811 24.69771081954085 0.9548914159395104 0.8758471781905061 0.13347562924398826 0.10312435701300365 1584.1038035089805 3117519.0732088704 0.04424749231702026 0.030063765535753705 5.321217877619465e-08 7.273988958494811 -0.07904423774900438 TEVSETARPSS(ph)PDTR ddPTM_A459_Selumetinib_30min_R1 1 TEVSETARPSSPDTR 15 1 O75132 O75132 ZBED4 Zinc finger BED domain-containing protein 4 1 TEVSET(0.055)ARPS(0.178)S(0.766)PDT(0.001)R 164.63 0.00044147 11515000.0 1251.5 1420.1 1446.0 1247.9 1803.6 1258.3 1074.8 1331.1 585.05 1072.4 True False 1280.657515004911 1253.834031813421 1249.641142309446 1029.977690984181 1640.4646984514427 1245.6426444449878 993.7269706735558 1295.7949039778407 992.7871196386423 1210.0529860605864 1.058348295287616 1.036181098065273 1.0327160518629368 0.8511839587598116 1.3556965830001315 1.029411652873372 0.8212259976389172 1.0708579863071892 0.820449295258327 1.0 10.240854506586068 -7.0172532287555205 24.872680193372023 0.9327925172235979 1.065378343764319 0.19278954657169123 0.1344543223410496 1241.4097531943262 1789643.5763635742 0.04993625032547798 0.03962961477058545 9.610517442021161e-08 7.0172532287555205 0.13258582654072104 TEVSETARPSSPDT(ph)R ddPTM_A459_Selumetinib_30min_R2 2 TEVSETARPSSPDTR 15 1 O75132 O75132 ZBED4 Zinc finger BED domain-containing protein 4 1 TEVSETARPS(0.274)S(0.274)PDT(0.452)R;TEVS(0.001)ET(0.094)ARPS(0.196)S(0.196)PDT(0.514)R 193.32 0.00029356 13025400.0 27008.0 25510.4 30241.0 32263.0 34497.0 25221.8 23584.4 25689.0 18010.4 26866.0 True False 25507.003481590236 27466.965651135473 28295.326983911265 27868.723743220697 30163.178452907072 28695.874009295512 24681.121331602022 25763.750736957103 21612.983252621838 26090.308773749006 0.9776428367629874 1.0527650664974728 1.0845148376465692 1.0681638145755123 1.1561066108675577 1.0998671674659566 0.9459880887433249 0.9874835503242311 0.8283912405961225 1.0 14.671226397822117 -7.270036487878874 22.605072668176405 0.9394226304132112 1.076305970643681 0.5417838242241393 0.0597462020922932 136.99992862272188 360220.9457402322 0.025075200065537727 0.017260485052970717 5.3698667876268534e-08 7.270036487878874 0.13688334023046989 TEYMAFPKPFESSS(ph)SIGAEKPR ddPTM_A459_Selumetinib_30min_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 TEYMAFPKPFES(0.023)S(0.228)S(0.597)S(0.152)IGAEKPR 79.94 0.00048534 22993000.0 2154.4 3307.6 3219.0 3299.6 2330.3 3257.4 3272.7 2891.3 1594.4 2526.7 True False 2204.5933282673427 2920.344654338477 2781.8774807013197 2723.386801163074 2119.5247764478804 3224.6335134825604 3025.837604134115 2814.613331734 2705.5803496314 2851.0265571421896 0.7732629928488571 1.0243133817966854 0.9757459023776391 0.9552302465722875 0.7434251256405161 1.1310429590367852 1.0613151240397958 0.9872280300872787 0.9489846184889341 1.0 11.477265762618728 -6.781876826854673 24.999998105945004 1.0271409074788922 0.9095122559545447 0.32737846508749335 0.09284762268526554 337.32162086365605 412623.99109290674 0.033412340184131264 0.029500460796650644 1.6524303885441926e-07 6.781876826854673 -0.11762865152434754 TFAPEEIS(ph)AMVLTK ddPTM_A459_Selumetinib_30min_R2 1 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 T(0.218)FAPEEIS(0.782)AMVLTK 87.447 0.037787 0.0 7570.8 5372.6 8120.8 6843.0 6980.0 6190.2 5952.9 5452.5 4286.7 7519.5 True False 7150.045244313661 5784.661144368195 7598.31656925851 5910.971595166575 6103.1099980082745 7042.843860959219 6229.721645447571 5468.365872290029 5144.159780405429 7302.392496992688 0.9791373508419647 0.792159712964 1.0405242627519256 0.8094568454928798 0.835768551268874 0.9644570411491359 0.8531069300935453 0.748845789176909 0.7044485464899244 1.0 12.834153499072633 -7.532503786194065 10.653531065620326 0.7960983493061424 0.898338378338986 0.11322237994046302 0.10315731391142381 0.45764693713056104 466.97993704309806 0.045342736706493095 0.026728568872438165 2.934243923006139e-08 7.532503786194065 0.10224002903284357 TFCGT(ph)PDYIAPEIIAYQPYGK ddPTM_A459_Selumetinib_30min_R2 1 TFCGTPDYIAPEIIAYQPYGK 21 0 P17252;P05129-2;P05771;P05129;P05771-2 P17252;P05771-2 PRKCA;PRKCG;PRKCB Protein kinase C alpha type;Protein kinase C gamma type;Protein kinase C beta type 1 T(0.388)FCGT(0.612)PDYIAPEIIAYQPYGK 108.55 0.00016725 2962700.0 30208.0 15996.0 27407.0 32599.0 21680.0 28916.0 15352.0 15843.0 11697.0 17822.0 True False 28529.16029220517 17222.841764753313 25643.66345848536 28158.95996358836 18956.36457834089 32898.916526686815 16065.898419410896 15889.10050705015 14036.726841486998 17307.432552883012 1.6483762224717082 0.9951124588889062 1.4816561254900702 1.626986549134218 1.0952730580009225 1.9008548163434342 0.9282658401424592 0.9180506963410584 0.8110230560539615 1.0 14.079104105528096 -7.404532676116308 11.058491499075148 0.9033881224682164 1.4291593802891336 0.527783976496919 0.25108122143697703 0.39054321255568997 34.31243190698684 0.1004707146976859 0.06769057994101188 3.939737841239539e-08 7.404532676116308 0.5257712578209172 TFCPPPLPKPSSTTPTPLVS(ph)ETGGNSPSDKVDNELK ddPTM_A459_Selumetinib_30min_R1 1 TFCPPPLPKPSSTTPTPLVSETGGNSPSDKVDNELK 36 2 A0A3B3IRW6;Q2KHR3-2;Q2KHR3;H0YCQ7 A0A3B3IRW6 QSER1 Glutamine and serine-rich protein 1 1 TFCPPPLPKPS(0.009)S(0.009)T(0.009)T(0.009)PT(0.081)PLVS(0.285)ET(0.285)GGNS(0.285)PS(0.029)DKVDNELK 50.042 0.0034691 42807000.0 3455.3 3351.2 4969.5 4262.1 3264.1 3996.9 3535.7 3612.4 2137.2 3424.3 True False 3535.8017671565867 2958.839946069386 4294.669195509539 3517.804244525743 2968.86273132366 3956.69481489484 3268.9993023915986 3516.587417271092 3626.67230508795 3863.84226050659 0.915099926127162 0.7657765888407285 1.1115022058241228 0.9104419920249338 0.7683705832583371 1.0240311451989959 0.8460488503386778 0.9101270652829474 0.9386181061678371 1.0 11.915820482709984 -8.612871498543031 2.548997047874779 0.9997845305398726 0.9061634695346924 0.07687305302474656 0.09924141975400662 1.1088535109777586 16.401309068417504 0.09300848952988866 0.02512369276292593 2.4385322380608863e-09 8.612871498543031 -0.0936210610051802 TFCPPPLPKPSSTTPTPLVSETGGNS(ph)PSDKVDNELK ddPTM_A459_Selumetinib_30min_R1 1 TFCPPPLPKPSSTTPTPLVSETGGNSPSDKVDNELK 36 2 A0A3B3IRW6;Q2KHR3-2;Q2KHR3;H0YCQ7 A0A3B3IRW6 QSER1 Glutamine and serine-rich protein 1 1 TFCPPPLPKPSSTTPT(0.008)PLVS(0.093)ET(0.34)GGNS(0.396)PS(0.162)DKVDNELK 82.15100000000002 3.331800000000001e-07 57840000.0 4500.4 4876.4 5908.1 6359.0 4229.5 4508.1 4011.5 4728.6 2393.4 3826.9 True False 4605.250563745988 4305.468821023146 5105.81247087029 5248.520023213725 3846.9424717788725 4462.752607027301 3708.9093253228198 4603.182167342513 4061.4249929803027 4318.119892162679 1.0664943722624391 0.9970702362473782 1.1824156342062806 1.2154641729007356 0.8908836641523117 1.033494372198217 0.8589176349768409 1.0660153683313003 0.9405540129517307 1.0 12.076187584860694 -6.268280730098357 24.99839858599881 0.966401128023415 1.1117013662771178 0.45693885501871323 0.08026721490200121 526.7104359877288 1924606.3752612427 0.02509644289334233 0.02909533739080655 5.391619928738508e-07 6.268280730098357 0.14530023825370275 TFDHYCEYR ddPTM_A459_Selumetinib_30min_R1 2 TFDHYCEYR 9 0 Q14204;A0A2R8Y6H2;A0A2R8YFZ7;A0A2R8YGC7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 ; 157.34 0.0012023 25284000.0 7998.9 10772.8 9378.4 10936.7 9332.2 9039.1 8671.8 8559.2 5029.5 6279.6 False True 8185.258806850003 9511.515567861148 8104.8647918637025 9026.810652285183 8488.104157733735 8948.174860846142 8017.679144293767 8332.18221180011 8534.694159853938 7085.647828483826 1.1551884887569228 1.3423635774876501 1.1438424528075886 1.273957000233347 1.1979291609176692 1.2628591029990346 1.1315379113344073 1.1759238411913868 1.2045044244994851 1.0 12.790684046939377 -14.522878745277456 0.18710836793768593 0.0854708207322688 1.2520195109773171 0.527854347904186 0.06103051851721585 98.4184329824006 0.9558398708367242 33.370024132602126 0.15947967990389486 3.000000000019904e-15 14.522878745277456 1.1665486902450484 TFDHYCEYR ddPTM_A459_Selumetinib_30min_R2 4 TFDHYCEYR 9 0 Q14204;A0A2R8Y6H2;A0A2R8YFZ7;A0A2R8YGC7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 ;;; 136.99 0.003642 26615800.0 190869.0 161645.0 197289.0 200244.0 216104.0 178054.0 168159.0 172408.0 149544.0 193092.0 False True 180261.26508914545 174042.65172940382 184595.64053202159 172970.42175983274 188955.08352572782 202579.32228671646 175978.72670073697 172909.6787363192 179456.97860847515 187516.9322467337 0.9613066027123286 0.9281436595837623 0.9844211843714024 0.9224256161157717 1.0076694475627503 1.0803254930608814 0.9384684603798081 0.9221016825766202 0.957017462147614 1.0 17.516661347194493 -3.6579851745559946 19.5769465116863 0.969144288043752 0.9729700671642803 0.0 0.04717742572169468 0.0 0.0 0.011424583539262317 0.0 0.00021979349020702558 3.6579851745559946 0.003825779120528283 TFDS(ph)PDSDEEEMK ddPTM_A459_Selumetinib_30min_R2 1 TFDSPDSDEEEMK 13 0 M0QZ23;M0R2B3;Q9H6X5-2;Q9H6X5 M0QZ23 C19orf44 Uncharacterized protein C19orf44 1 T(0.033)FDS(0.637)PDS(0.33)DEEEMK 139.19 0.0013994 0.0 6340.1 5891.0 6615.4 5910.1 5815.8 4038.5 6177.4 6845.9 6044.1 5709.4 True False 5987.7426234312115 6342.820757449476 6189.772366302921 5105.134184508838 5085.167210088327 4594.766717147068 6464.661340285877 6865.820435600244 7253.08888626414 5544.554787197299 1.0799320871095472 1.1439729610203184 1.1163695921258576 0.9207473603285319 0.9171461740860195 0.8286989476155332 1.1659477791099038 1.23829968304287 1.3081463101441337 1.0 12.43685590517718 -7.495800496334609 23.00514613007403 1.2043586046050163 1.0047284463747543 0.3502238537667144 0.11700621925158788 292.7551856047793 248720.18413810295 0.05279504535177135 0.0354420777927608 3.1930043019390813e-08 7.495800496334609 -0.19963015823026198 TFGCDDELMYGGVSSYEGSMALNARPQS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TFGCDDELMYGGVSSYEGSMALNARPQSPR 30 1 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 TFGCDDELMYGGVS(0.011)S(0.011)Y(0.004)EGS(0.006)MALNARPQS(0.967)PR 71.071 0.00011733 6841500.0 1086.7 1158.6 1351.4 1326.8 2002.1 1104.4 1678.6 1496.2 568.26 666.03 True False 1112.0179956498896 1022.9505733814723 1167.887302708843 1095.099287120611 1821.0104084994641 1093.2907387149687 1551.9818505513867 1456.515915657459 964.2957159317232 751.5214381815855 1.4796889871040506 1.36117284405971 1.5540305883152379 1.4571763777895168 2.4230984187299587 1.454769861735872 2.065119864453409 1.9380896427674894 1.2831246947059498 1.0 9.553670449361624 -8.478181665564199 4.605850986348511 1.0024319330595706 1.7151674511862944 0.35812107572800056 0.31882600251472454 0.19982413333046087 9.624355137340277 0.316231003777364 0.08248789315886751 3.3252043076266853e-09 8.478181665564199 0.7127355181267239 TFGHNT(ph)MDAVPR ddPTM_A459_Selumetinib_30min_R2 1 TFGHNTMDAVPR 12 0 G3XAL9;P55011-3;P55011 G3XAL9 SLC12A2 Solute carrier family 12 member 2 1 T(0.064)FGHNT(0.936)MDAVPR 111.43 0.009219 8060300.0 36126.0 6684.8 23199.0 24871.0 17830.0 10593.0 28130.0 26754.0 18289.0 11719.0 True False 34118.261543836205 7197.502664980182 21706.40159716138 21483.526895131934 15590.035997777588 12052.089596320151 29438.100738537527 26831.849710636856 21947.311037356227 11380.642020381327 2.997920634243183 0.6324337987338801 1.9073090567551367 1.8877253898907975 1.3698731556495456 1.0589990946676247 2.586681901233473 2.357674519819209 1.928477409099706 1.0 13.474294326780381 -7.264606731902677 24.909510722100602 2.081347954350989 1.6072784110683747 0.03824320804773018 0.7024421721356177 669.565605733182 5265729.242799059 0.27179179554457533 0.19199008617291724 5.4374248553255737e-08 7.264606731902677 -0.4740695432826143 TFIAIKPDGVQR ddPTM_A459_Selumetinib_30min_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 111.5 0.019087 45974000.0 3549.7 4125.3 4101.1 4333.2 4049.3 3707.7 3722.6 3684.0 2101.9 2814.6 False True 3632.401103486163 3642.307958200062 3544.1931457297856 3576.487964238042 3683.0415299619804 3670.403904322248 3441.801284917547 3586.288352681516 3566.7707832979418 3175.8813265256686 1.1437458550946282 1.146865258402036 1.115971530840241 1.1261403045404805 1.1596911695661916 1.1557119196067613 1.0837310752674716 1.129226184469815 1.1230806244261955 1.0 11.632941288820644 -14.522878745279613 0.25655812450218907 0.16385356331602288 1.142330579232332 0.8039895999132464 0.019787254895925713 83.70207059364594 0.8238652323128124 36.78108555721768 0.028229810284386817 3.0000000000050075e-15 14.522878745279613 0.9784770159163091 TFIAIKPDGVQR ddPTM_A459_Selumetinib_30min_R2 2 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 ; 116.74 0.013916 41781000.0 154369.0 150776.0 157077.0 148088.0 181511.0 135217.0 145468.0 154232.0 117536.0 150886.0 False True 145789.7889680689 162340.03437874734 146970.83683250664 127918.15893395098 158707.96545107156 153841.91437228568 152232.55023937376 154680.78958551795 141046.48423023103 146529.52913109097 0.994951596668544 1.1078997888098834 1.0030117322019159 0.8729855319436021 1.083112505664884 1.0499038336133106 1.038920626730334 1.0556287903384618 0.9625806147513475 1.0 17.16083190521468 TFLEGDWT(ph)SPSK ddPTM_A459_Selumetinib_30min_R1 2 TFLEGDWTSPSK 12 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 TFLEGDWT(0.496)S(0.496)PS(0.009)K;TFLEGDWT(0.98)S(0.019)PS(0.001)K 141.58 0.0022915 243160000.0 9993.3 10736.1 12230.6 13107.9 9940.400000000001 9380.7 10271.4 9809.1 5280.1 8985.8 True False 10226.124446423159 9479.112420922515 10569.751697876847 10818.8513307569 9041.292575120167 9286.338674994126 9496.620028448415 9548.930803552728 8959.944056754108 10139.214959104083 1.0085716189734235 0.9348960899986781 1.0424625319129053 1.0670304727135276 0.891715247342884 0.9158834004851477 0.9366228121952699 0.941782065186286 0.8836920898603596 1.0 13.307658333818535 -6.271509856737928 24.998727207446283 0.9251687557028487 1.0097314843256366 0.47682402506705446 0.043461204584831784 627.7886438314354 1558405.4563795065 0.013634615260878353 0.015624514405788678 5.351680074722247e-07 6.271509856737928 0.08456272862278791 TFLEGDWTS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 TFLEGDWTSPSK 12 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 TFLEGDWT(0.048)S(0.951)PS(0.001)K 97.779 0.015889 5043700.0 2491.8 2835.4 3552.0 3259.4 2736.0 2477.1 2933.8 2689.6 1507.1 2552.9 True False 2549.8540918012286 2503.4300498583025 3069.657909739386 2690.206976515615 2488.529283080032 2452.1826230268466 2712.50110398407 2618.2630709479386 2557.4386257711258 2880.5895823517985 0.8851847925241236 0.8690686327534477 1.065635288187506 0.9339084585313436 0.8638958143590603 0.8512780293487044 0.9416478906271347 0.908933048633159 0.8878177722503451 1.0 11.492148408997222 -10.786255233672213 3.1193696931368122 1.0004329974450923 0.9134257745725941 0.16935278584880487 0.05842977603259964 26522208.22656651 36943458.831444204 110380.3692737789 0.015083108280458918 1.6358548514743368e-11 10.786255233672213 -0.08700722287249818 TFLEGDWTS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 4 TFLEGDWTSPSK 12 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 TFLEGDWT(0.061)S(0.937)PS(0.002)K;TFLEGDWT(0.071)S(0.924)PS(0.005)K;TFLEGDWT(0.286)S(0.713)PS(0.001)K;TFLEGDWT(0.275)S(0.713)PS(0.013)K 182.07 0.00010416 68201000.0 447932.0 424222.0 453711.0 462572.0 458342.0 359041.0 404964.0 389244.0 323644.0 434368.0 True False 423037.73265386815 456758.4633112773 424519.72822318674 399568.89561879105 400760.9803305309 408495.6387003094 423795.62842094316 390376.635597187 388381.84336891706 421826.6672164009 1.0028710025505476 1.082810781796676 1.0063842834417205 0.9472347925642373 0.950060798609816 0.968396904339733 1.0046677020624022 0.9254432351876896 0.9207142970163943 1.0 18.68629077735585 -5.567074444554711 4.373641695422516 0.9586237108134035 1.0437765280087663 0.5356692504734044 0.03151231578794108 0.14274922041539984 5.9497313380178944 0.008649302069178287 0.016115967781139766 2.709727104418448e-06 5.567074444554711 0.08515281719536283 TFLEGDWTSPS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 TFLEGDWTSPSK 12 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 TFLEGDWT(0.018)S(0.402)PS(0.58)K 115.57 0.0052229 5009700.0 1854.7 1773.4 2078.5 2225.3 1858.1 1762.2 1866.3 1631.9 1162.9 1371.1 True False 1897.910901382028 1565.769503568707 1796.251116383253 1836.6931290544896 1690.0351830741986 1744.4738679495824 1725.5234884332508 1588.6167108417376 1973.3563651444786 1547.0940406449743 1.2267585883730767 1.0120713172134947 1.1610484360953306 1.1871890659528255 1.0923933120249323 1.1275810145466798 1.11533199863784 1.0268391378325346 1.2755245080782536 1.0 10.59534517883018 -11.116926079397544 2.8667213271277667 0.991142615420561 1.1293137181525876 0.21029482449887416 0.07812693192552318 50356912.214021325 49297709.83303447 3356191.7552378597 0.018742049821677036 7.639658059684484e-12 11.116926079397544 0.1381711027320266 TFNT(ph)STGGLLLPSDTKR ddPTM_A459_Selumetinib_30min_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 T(0.307)FNT(0.59)S(0.096)T(0.007)GGLLLPSDTKR 78.057 0.023973 14588000.0 957.59 1085.6 1354.9 1730.9 1165.7 1130.1 1187.8 1097.9 776.71 793.49 True False 979.8999838542173 958.4974473182517 1170.9120219329666 1428.6308080170838 1060.26264082105 1118.732220048702 1098.203289696734 1068.7801255181964 1318.02014134609 895.3421707471229 1.094441897042038 1.0705375873432037 1.307781605948364 1.595625510216899 1.1841982601314405 1.2495024322546655 1.2265738458184456 1.1937113658193352 1.4720854042273708 1.0 9.806295328799502 -11.69010837749133 2.4932043110919935 0.30776511506861853 1.265038362380124 0.21377487676072482 0.15305573556030266 2738780.3140880927 2694403.2501021395 10382644.336340308 0.040127888833202056 2.041228495809202e-12 11.69010837749133 0.9572732473115055 TFNTS(ph)TGGLLLPSDTKR ddPTM_A459_Selumetinib_30min_R2 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 T(0.193)FNT(0.245)S(0.465)T(0.097)GGLLLPSDTKR 95.591 0.0032511 4745600.0 14174.0 18267.0 20071.0 22169.0 18493.0 15599.0 15353.0 14917.0 12228.0 18848.0 True False 13386.265823017628 19668.020162337394 18779.653711652492 19149.543956341913 16169.744010482376 17747.620656376665 16066.944921392356 14960.406000357705 14673.94167886664 18303.80926701485 0.7313377028649939 1.0745315292255027 1.0259970172162556 1.0462053923852426 0.883408681471662 0.9696135048981039 0.877792413972892 0.8173383901742101 0.80168785987682 1.0 14.159856303399593 -7.3286258842369225 3.727916795018134 0.8554265155264026 0.9652462496187926 0.11451536985542554 0.10439515743320163 0.41499604067464185 11.409667385032659 0.04559402353422609 0.030133669303900244 4.6921740763675923e-08 7.3286258842369225 0.10981973409238999 TFPLAHS(ph)PQAECEDQLDAQER ddPTM_A459_Selumetinib_30min_R2 2 TFPLAHSPQAECEDQLDAQER 21 0 A0A1W2PRB5;A0A0J9YVS1;A0A3B3IT55;A0A0G2JNB1;A0A0G2JNT7;Q7Z3B3;A0A0G2JQF5;A0A0G2JQF4;Q7Z3B3-4;Q7Z3B3-2 A0A1W2PRB5 KANSL1 KAT8 regulatory NSL complex subunit 1 1 TFPLAHS(1)PQAECEDQLDAQER;TFPLAHS(1)PQAECEDQLDAQER 171.04 1.2014e-10 41653000.0 118634.0 99618.0 107803.0 141571.0 144991.0 101018.0 110114.0 97246.0 88639.0 112625.0 True False 112040.79720952953 107258.38027764403 100867.07234703178 122288.785576403 126775.9343440141 114932.31254989798 115234.5191867517 97528.9697600581 106369.27678059063 109373.22361510743 1.0243896404096993 0.9806639754451629 0.9222282110106818 1.1180870558112688 1.159113082285552 1.0508267814648438 1.0535898584489984 0.8917079202426167 0.9725348971601321 1.0 16.738900060044756 -7.742053436300251 24.989170364713395 0.9490910509397577 1.0445236702397336 0.2724645433027387 0.06673680959986275 321.74865958268174 414746.5046183388 0.035005549465070326 0.020172057523412088 1.8111172360956464e-08 7.742053436300251 0.09543261929997593 TFQARPLS(ph)ADLTK ddPTM_A459_Selumetinib_30min_R1 1 TFQARPLSADLTK 13 1 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 TFQARPLS(0.994)ADLT(0.006)K 137.27 0.0049836 21976000.0 2408.4 2089.5 2947.5 3167.3 2469.5 2133.8 1919.9 2116.7 1219.2 1829.6 True False 2464.5110340693795 1844.8603686178044 2547.2456894585725 2614.1905125844964 2246.134161025637 2112.3359093353865 1775.0803972796432 2060.558239989404 2068.89335315517 2064.4469818131743 1.1937875158725726 0.8936341717032084 1.233863456847588 1.2662909416489303 1.0880076750883132 1.0231969762091697 0.8598333659896732 0.9981163275889241 1.0021537832558387 1.0 11.011539653015179 -6.791404479387271 3.127896599759653 0.963466172431687 1.1377797037547455 0.38568738341358844 0.10254462602751756 0.2811276089494205 5.660024190483535 0.039381361618439616 0.03599859240042009 1.6165737432515e-07 6.791404479387271 0.1743135313230585 TFQEDSSPVVHQS(ph)LQEVSEPLTATK ddPTM_A459_Selumetinib_30min_R1 2 TFQEDSSPVVHQSLQEVSEPLTATK 25 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 TFQEDSSPVVHQS(0.999)LQEVS(0.001)EPLTATK;TFQEDSSPVVHQS(1)LQEVSEPLTATK 101.88 0.00014705 0.0 2283.96 2618.6 2564.49 3082.8999999999996 2441.2 2500.6 2365.94 2151.1 929.6500000000001 1392.21 True False 2337.1718241874696 2312.013094645888 2216.2463437352376 2544.529388200281 2220.393891028866 2475.4462343631403 2187.4752409707767 2094.0458402424547 1577.5481510504467 1570.9137147737868 1.487778610758405 1.471763262935686 1.41080081158651 1.6197766715447488 1.4134410248933407 1.5758002562983588 1.3924859273927566 1.3330113681921731 1.004223297698827 1.0 10.617388224882593 -8.106574798233455 1.8409637045002443 0.9771841800985859 1.489822345213008 0.8879956905945945 0.06735775093435802 0.10106351964887308 0.6099891950858489 0.057134864583646694 0.017896348254850925 7.823934423890824e-09 8.106574798233455 0.5126381651144221 TFQQIQEEEDDDYPGS(ph)YSPQDPSAGPLLTEELIK ddPTM_A459_Selumetinib_30min_R1 2 TFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIK 34 0 Q9NQG5;A2A2M0 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 1 TFQQIQEEEDDDY(0.013)PGS(0.341)Y(0.3)S(0.341)PQDPS(0.004)AGPLLTEELIK;TFQQIQEEEDDDY(0.003)PGS(0.322)Y(0.266)S(0.322)PQDPS(0.08)AGPLLT(0.006)EELIK 101.44 1.0564e-11 10199100.0 3050.0 3115.5 3278.7 3807.7 3259.5 3019.0 3173.6000000000004 3016.7 1665.21 2719.3 True False 3121.0590657331013 2750.735811643343 2833.4705486099474 3142.756674381333 2964.678800511464 2988.63160103268 2934.2127969199832 2936.687316377396 2825.7397478736216 3068.3486432250575 1.0171787592079633 0.896487372032182 0.9234513016851188 1.0242501879050052 0.9662131476022136 0.9740195618355191 0.9562840270445644 0.9570904932402742 0.9209317702904725 1.0 11.583246704033145 TFS(ph)ATVR ddPTM_A459_Selumetinib_30min_R1 1 TFSATVR 7 0 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 T(0.332)FS(0.668)ATVR 82.75 0.040577 4731600.0 3408.7 3985.6 3497.5 3753.0 2510.2 3485.6 3223.1 2923.6 1951.8 2395.4 True False 3488.116077824402 3518.9640991448296 3022.5587103923162 3097.609002535164 2283.1528532118036 3450.538028671584 2979.978972067302 2846.0566308088137 3312.062046168194 2702.872923171884 1.2905216697095094 1.301934718786277 1.1182762920445677 1.1460431513369294 0.8447133543120743 1.2766186671559452 1.102522781045225 1.0529746353997658 1.2253857803575212 1.0 11.400277969150524 -5.302840111377613 3.6596693449874964 1.0948011054724909 1.3006265835397524 0.33804622838544895 0.11242703407973155 0.24962845463397648 7.002941466374611 0.029328802730940667 0.07344926686808764 4.97920364185502e-06 5.302840111377613 0.20582547806726148 TFS(ph)ATVR ddPTM_A459_Selumetinib_30min_R2 4 TFSATVR 7 0 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 T(0.11)FS(0.87)AT(0.02)VR;T(0.025)FS(0.516)AT(0.459)VR;T(0.212)FS(0.573)AT(0.215)VR;T(0.286)FS(0.712)AT(0.002)VR 88.819 0.031777 735489000.0 345498.0 334528.0 403067.0 415603.0 367454.0 261376.0 309292.0 296535.0 216951.0 330032.0 True False 326296.60429807665 360185.2219229438 377134.10804616846 358997.1544448368 321291.1434395602 297378.1714649081 323674.690850471 297397.86775598844 260347.26211741826 320503.1186338842 1.0180762224370443 1.1238119100313313 1.1766940354704465 1.1201050272928075 1.0024587118185773 0.9278479808011102 1.0098956048543468 0.9279094350894936 0.8123080462590353 1.0 18.28997886939549 -6.440056862212678 2.8522622748568445 0.9359853502069605 1.115850196558113 0.634295125309001 0.0621492322654463 0.18013021825761547 2.8602165865751514 0.021732066455974666 0.024389120340455196 3.630305200420884e-07 6.440056862212678 0.1798648463511524 TFS(ph)DGLATR ddPTM_A459_Selumetinib_30min_R2 2 TFSDGLATR 9 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 T(0.005)FS(0.995)DGLATR;T(0.024)FS(0.976)DGLATR 125.23 0.0050952 19715700.0 96910.0 40656.0 65436.0 96991.0 93511.0 35961.0 67771.0 86664.0 49121.0 48326.0 True False 91524.13016146726 43774.18447035576 61225.919001329865 83780.65848119261 81763.31218105317 40914.30132854423 70922.4857856888 86916.17789200236 58946.57255541446 46930.70281397284 1.9501973052535972 0.9327408678252889 1.3046026445421324 1.7851993142589015 1.7422136741730085 0.8718024422247235 1.5112172103370418 1.852011000911849 1.2560343020872913 1.0 15.518244445256368 TFS(ph)FLMNR ddPTM_A459_Selumetinib_30min_R2 1 TFSFLMNR 8 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 T(0.002)FS(0.998)FLMNR 102.06 0.016528 3473800.0 21633.0 16332.0 20569.0 21950.0 16799.0 16017.0 20669.0 15116.0 12890.0 15917.0 True False 20430.724463760413 17584.611884343027 19245.6129338339 18960.372134137997 14688.55943503453 18223.196362150462 21630.149454846516 15159.985057411479 15468.3601766921 15457.434852667415 1.3217409394570265 1.1376151380840875 1.2450715864096156 1.2266182788320856 0.9502585373989008 1.1789275863585977 1.3993362845138504 0.9807568462625863 1.0007068005868256 1.0 13.916013304738154 -1.522878745313713 0.0757885177784642 0.8155432928979568 1.9776444937894493 0.2656351634387246 0.127263216273791 337.699520443922 1.8834813109529573 4.638030550107795 41.37012024548115 0.029999999997694513 1.522878745313713 1.1621012008914926 TFS(ph)LDAVPPDHSPR ddPTM_A459_Selumetinib_30min_R1 4 TFSLDAVPPDHSPR 14 0 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 T(0.073)FS(0.927)LDAVPPDHSPR;T(0.164)FS(0.836)LDAVPPDHSPR;T(0.128)FS(0.872)LDAVPPDHSPR;T(0.072)FS(0.928)LDAVPPDHSPR 108.25 0.0032707 83407800.0 13281.6 15228.7 16262.7 18326.4 15717.599999999999 14634.3 14809.0 13687.5 7802.599999999999 13006.2 True False 13591.035438505183 13445.716724369435 14054.314664616762 15126.038269134136 14295.945855167656 14487.092228881262 13691.945207205694 13324.463036734047 13240.442320643475 14675.672461116375 0.9260928570404545 0.9161908430427468 0.9576606933586234 1.0306879162921507 0.9741254373893383 0.9871501471067331 0.9329688464690735 0.9079286194235803 0.9022034496698135 1.0 13.841138990829611 -9.988115725295362 11.468046304685915 1.0000000077336249 0.9503452627194056 0.13943961221598544 0.03821256721185084 0.0 0.0 0.041595256882572776 0.010088331626561623 1.027742401851879e-10 9.988115725295362 -0.04965474501421929 TFS(ph)LDAVPPDHSPR ddPTM_A459_Selumetinib_30min_R2 2 TFSLDAVPPDHSPR 14 0 Q9BST9-3;Q9BST9-2;Q9BST9 Q9BST9-3 RTKN Rhotekin 1 T(0.262)FS(0.738)LDAVPPDHSPR;T(0.008)FS(0.992)LDAVPPDHSPR 91.616 0.011081 21033300.0 29808.7 28933.2 32900.1 35388.0 33836.0 33663.0 30681.5 29075.4 24693.6 29833.0 True False 28152.05178768065 31152.28340509882 30783.34338492045 30568.093352294993 29585.219182322046 38299.77268771126 32108.250544238865 29160.00460030843 29633.00999683196 28971.643774557197 0.9717105458960424 1.0752680672008212 1.062533545713215 1.0551038660478007 1.0211784810188675 1.3219744445893675 1.1082647154607164 1.0065015581172048 1.0228280530929201 1.0 14.822353921186602 -4.753262127351164 4.428736545052372 1.0817290444979306 0.9610975140407506 0.10418344911437138 0.08886989468734184 0.547540206043632 22.742457444449595 0.023420679572221947 0.21441514533381847 1.764972213917287e-05 4.753262127351164 -0.12063153045718 TFS(ph)LTEVR ddPTM_A459_Selumetinib_30min_R1 4 TFSLTEVR 8 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 TFS(0.998)LT(0.002)EVR;TFS(0.864)LT(0.136)EVR;T(0.001)FS(0.987)LT(0.012)EVR;T(0.001)FS(0.987)LT(0.012)EVR 171.33 0.00016329 236369000.0 16017.1 17432.800000000003 20944.399999999998 22537.699999999997 18430.8 16693.0 18736.7 18515.1 9976.7 13323.099999999999 True False 16390.26726614874 15391.759671711145 18100.265519354063 18601.913780025763 16763.737394222033 16525.083576031302 17323.375633996293 18024.019402479233 16929.73123066207 15033.24966298377 1.0902677487294277 1.02384780514955 1.2040154939967622 1.2373847436212733 1.1151106893075307 1.0992356241326093 1.1523373869491091 1.1989436619854459 1.126152469372473 1.0 13.875869282743475 -5.253570394332483 24.99560900222848 1.150091154503692 1.057057774280529 0.20558445412263138 0.06483499094615452 813.5048082022769 2584059.8246363467 0.016236599786867794 0.04131999637295452 5.577371917835861e-06 5.253570394332483 -0.0930333802231631 TFS(ph)LTEVR ddPTM_A459_Selumetinib_30min_R2 4 TFSLTEVR 8 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 T(0.002)FS(0.965)LT(0.032)EVR;TFS(0.846)LT(0.154)EVR;TFS(0.634)LT(0.366)EVR;TFS(0.976)LT(0.024)EVR 147.73 0.0016672999999999998 98493900.0 68090.0 72140.0 80386.7 83576.0 85465.0 69136.3 73143.0 76396.0 63850.0 92389.0 True False 64305.830385866415 77672.90603334003 75214.70724042131 72192.8046233583 74728.12263320593 78659.19776815522 76544.29443010497 76618.29971196128 76621.78411805979 89721.48951454983 0.7167271824598739 0.8657112855972379 0.8383131805700127 0.8046322571545252 0.832889902269038 0.876704100586731 0.8531322300182281 0.8539570634249931 0.8539958992280695 1.0 16.453165951126294 -14.522878745279707 0.12217758411667295 1.5333372042932787 0.7594042929437027 0.6893613221315058 0.0368648178704404 89.81438268096342 0.7046814691348515 11.823196155523366 0.3326026565846439 3.000000000004357e-15 14.522878745279707 -0.773932911349576 TFS(ph)SSPPKPGDIFEVELAK ddPTM_A459_Selumetinib_30min_R1 1 TFSSSPPKPGDIFEVELAK 19 1 Q12923-3;Q12923;Q12923-4;Q12923-2 Q12923-3 PTPN13 Tyrosine-protein phosphatase non-receptor type 13 1 T(0.155)FS(0.282)S(0.282)S(0.282)PPKPGDIFEVELAK 89.344 0.0016138 10772000.0 1595.2 1935.3 2122.6 2413.7 1806.0 1906.6 1684.8 1539.1 1220.4 1448.1 True False 1632.3650562811306 1708.714176303438 1834.3625786072148 1992.1926057604906 1642.6476188751967 1887.4213350542916 1557.7141795597388 1498.2780682986202 2070.929665510638 1633.9777406884884 0.999013031593271 1.045738955772714 1.1226362103527143 1.2192287300811488 1.005305995284278 1.1551083518793914 0.9533264381578322 0.9169513335397762 1.2674160815911952 1.0 10.674172614769265 -7.2552084433739035 24.994103820340488 1.0275027412773339 1.092454711334067 0.06120743351283919 0.10745008893927359 1432.478987556234 5746112.472292215 0.041544052580313406 0.03134152400143389 5.5563751025718465e-08 7.2552084433739035 0.06495197005673314 TFS(ph)WASVTSK ddPTM_A459_Selumetinib_30min_R2 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 T(0.189)FS(0.795)WAS(0.008)VT(0.008)SK 97.163 0.020924 2674800.0 20293.0 24050.0 25793.0 24275.0 23358.0 15796.0 19622.0 21960.0 12477.0 23277.0 True False 19165.19629931541 25894.557667061606 24133.50646129504 20968.703123289277 20423.559216830545 17971.755618188705 20534.46188025537 22023.899964326287 14972.74863650793 22604.932529090893 0.847832492959278 1.1455268726742363 1.0676212561235026 0.9276162667729307 0.9035001184164969 0.7950369059965284 0.908406245133845 0.9742962044227799 0.6623664378223247 1.0 14.464349991075343 -5.971255633238801 3.2027854281343644 0.8716911209074949 1.0319966226492054 0.24701888439331599 0.11299438258989537 0.3163699346988684 6.72441299118186 0.032613613121394845 0.048972217665169036 1.0684258002037561e-06 5.971255633238801 0.16030550174171054 TFS(ph)YAGFEMQPKKY(ph)HNPK ddPTM_A459_Selumetinib_30min_R1 1 TFSYAGFEMQPKKYHNPK 18 2 Q99832-2;Q99832-4;Q99832-3;Q99832 Q99832-2 CCT7 T-complex protein 1 subunit eta 2 T(0.323)FS(0.356)Y(0.323)AGFEMQPKKY(0.999)HNPK 52.453 0.048013 0.0 645.49 660.33 787.81 635.05 530.09 834.88 725.94 875.29 457.2 578.0 True False 660.5286610951023 583.0182566209115 680.8297291305706 524.1504388648962 482.1434530949908 826.4818652103892 671.1817613423526 852.0744658573841 775.8350074331888 652.1919301967722 1.0127826342405293 0.8939366306556563 1.0439100786254103 0.8036751370210227 0.7392662048877602 1.2672371842457972 1.0291169366966118 1.306478087823481 1.1895808143457285 1.0 9.349152779991547 -6.769928242858853 24.999925419188013 1.169552141751042 0.9012352093057449 0.535510749809287 0.12073379726106717 146.28055502501164 430797.52865478717 0.0421652008001347 0.03777843540870649 1.6985242712180772e-07 6.769928242858853 -0.2683169324452971 TFS(ph)YIK ddPTM_A459_Selumetinib_30min_R1 1 TFSYIK 6 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36 Q12802-4 AKAP13 A-kinase anchor protein 13 1 T(0.094)FS(0.906)YIK 106.36 0.025937 52842000.0 4109.5 5307.9 5642.9 5988.2 5301.6 5719.9 5182.7 5331.7 3211.2 4057.7 True False 4205.243354304982 4686.448600424237 4876.625174230965 4942.473282435669 4822.0712160735 5662.362999253667 4791.764766384291 5190.2859961976155 5449.171863231532 4578.545320345059 0.9184671243983792 1.0235671534362023 1.0651036154565008 1.0794854995698029 1.053188486449248 1.2367165995043436 1.0465692553247814 1.1336102698676473 1.1901535273698807 1.0 12.160673587683359 -3.565942042973019 0.632015964528068 1.1198380489405337 0.12507588881553994 0.441416583110124 0.0655919789279683 11.978743478892513 1.1132635293558528 0.02772511900317875 12.216299643258603 0.00027168018045287324 3.565942042973019 -0.9947621601249939 TFSLT(ph)EVR ddPTM_A459_Selumetinib_30min_R2 1 TFSLTEVR 8 0 O95239;O95239-2 O95239 KIF4A Chromosome-associated kinesin KIF4A 1 T(0.055)FS(0.396)LT(0.549)EVR 99.013 0.044421 9042200.0 22562.0 18917.0 23883.0 25596.0 27156.0 21173.0 24142.0 23456.0 17731.0 27182.0 True False 21308.09436284207 20367.87307225796 22346.393781844272 22109.780644437185 23744.420502279754 24089.388560642565 25264.650836465473 23524.253076650148 21277.695445533558 26397.185032682395 0.8072108573872738 0.7715926166763791 0.8465445748922534 0.8375810002870773 0.8995057796080056 0.912574144963467 0.9570964027105644 0.8911652150608004 0.8060592604548406 1.0 14.688096469893805 -5.915508814572192 1.2909978524374242 0.9099927793188733 0.7912640629377689 0.49362937671195417 0.04870514291317679 0.40649936417266297 1.372375246528028 0.017588070478422587 0.03627120882438943 1.2147619650446719e-06 5.915508814572192 -0.1187287163811045 TFTAWCNSHLR ddPTM_A459_Selumetinib_30min_R1 1 TFTAWCNSHLR 11 0 O43707;F5GXS2;O43707-3;K7EP19;P12814-4;P12814-3;P12814;P12814-2;A0A494C1A0;P35609;P35609-2;G3V2N5;Q08043;A0A494C033;A0A494C166;A0A494C0Q3 O43707;P12814-4 ACTN4;ACTN1;ACTN2;ACTN3 Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-2;Alpha-actinin-3 0 114.24 0.0093252 7802100.0 3513.5 3939.2 3547.0 3913.2 4010.7 3564.0 3786.3 3751.3 2314.8 3679.5 False True 3595.3577139191 3477.996632715601 3065.3368822763523 3229.833079861603 3647.9328931465966 3528.1493958530887 3500.696342632383 3651.803338060307 3928.0465336971693 4151.7996663650965 0.86597572205762 0.8377082017930286 0.7383152195683991 0.777935675949732 0.8786389484780619 0.8497879665138048 0.8431756404319106 0.8795711815395619 0.946106953454278 1.0 12.019521116769628 -8.215906019235007 0.7011442104902725 1.003359197307832 0.8124796211368227 0.7082214130677906 0.03826297602050849 0.39368376171108066 0.430802215293103 0.04051359055490988 0.017246084936732464 6.082666151476111e-09 8.215906019235007 -0.19087957617100926 TFVNITPAEVGVLVGK ddPTM_A459_Selumetinib_30min_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 166.64 0.00022273 34692000.0 4234.4 3411.2 3882.6 3732.7 4832.1 4927.8 3646.7 3491.6 3180.7 4911.6 False True 4333.053281291885 3011.8151181761427 3355.3642455951976 3080.8540164569677 4395.037408176545 4878.230806084411 3371.626483024986 3398.991425684794 5397.415590863394 5542.051703035409 0.7818500283782357 0.5434476759800989 0.605437196437097 0.5559049575032958 0.7930343568915752 0.8802210927430683 0.6083715316438367 0.613309223337478 0.9739020637261833 1.0 12.436204454767747 -8.70367387073348 0.42669559084167435 1.0317836240796392 0.6340216201980403 0.43128157353513263 0.123996163881536 1.5790963051515479 0.6750228619190137 0.20734869807514858 0.09201055153591144 1.9784547840169166e-09 8.70367387073348 -0.3977620038815989 TFVNITPAEVGVLVGK ddPTM_A459_Selumetinib_30min_R2 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 124.81 0.017418 58414000.0 90944.0 72122.0 68593.0 67929.0 85683.0 50239.0 62963.0 92766.0 69179.0 78494.0 False True 85889.69655767703 77653.52549121888 64179.801058411555 58676.9530159389 74918.73552426117 57158.96622576495 65890.9042588176 93035.9337017619 83016.73302276031 76227.67426809555 1.1267521590072365 1.0187051649786476 0.8419488286194962 0.7697591928302822 0.9828285625082723 0.7498453386461031 0.8643960988115267 1.220500751138636 1.0890629134346588 1.0 16.21802723922385 -7.750094564064122 24.991109390820117 1.1160863827727596 0.9009920213251735 0.3593860049880472 0.11896331937256725 217.66748055747058 479494.9669238107 0.059263126364789746 0.03382468536764293 1.777892246423869e-08 7.750094564064122 -0.2150943614475861 TGDLGIPPNPEDRS(ph)PS(ph)PEPIYNSEGK ddPTM_A459_Selumetinib_30min_R1 6 TGDLGIPPNPEDRSPSPEPIYNSEGK 26 1 Q15637-6;Q15637-4;Q15637-7;Q15637-3;Q15637-2;Q15637;Q15637-5 Q15637-6;Q15637-5 SF1 Splicing factor 1 2 T(0.031)GDLGIPPNPEDRS(0.97)PS(0.998)PEPIY(0.001)NS(0.001)EGK;T(0.007)GDLGIPPNPEDRS(0.999)PS(0.989)PEPIY(0.002)NS(0.003)EGK;TGDLGIPPNPEDRS(1)PS(0.998)PEPIY(0.001)NS(0.001)EGK;T(0.012)GDLGIPPNPEDRS(0.997)PS(0.979)PEPIY(0.007)NS(0.006)EGK;TGDLGIPPNPEDRS(0.999)PS(0.993)PEPIY(0.003)NS(0.005)EGK;T(0.021)GDLGIPPNPEDRS(0.996)PS(0.972)PEPIY(0.004)NS(0.007)EGK 87.25 0.00014268 118412000.0 103896.20000000001 122921.1 113215.6 121059.5 105775.9 103745.5 113052.29999999999 107037.1 63865.3 100794.6 True False 106316.77931318663 108529.44046753107 97841.5433687756 99918.73089326019 96208.48852125202 102701.9144633773 104524.67399207107 104198.12840249903 108374.74956304216 113732.56873254603 0.934796254916229 0.9542512024216153 0.8602772667419495 0.8785410547459759 0.8459185402511772 0.9030123526436085 0.9190390682010507 0.9161678977596274 0.9528910739534658 1.0 16.79528592146091 -8.434576873563953 1.0927063971349997 0.9995513174072365 0.8955828790935586 0.5297635289342426 0.030535408147764617 0.43533419612817736 1.1325060693925395 0.03204241767532225 0.010440004373249974 3.676403123705729e-09 8.434576873563953 -0.10396843831367786 TGDLGIPPNPEDRS(ph)PS(ph)PEPIYNSEGK ddPTM_A459_Selumetinib_30min_R2 10 TGDLGIPPNPEDRSPSPEPIYNSEGK 26 1 Q15637-6;Q15637-4;Q15637-7;Q15637-3;Q15637-2;Q15637;Q15637-5 Q15637-6;Q15637-5 SF1 Splicing factor 1 2 T(0.002)GDLGIPPNPEDRS(0.99)PS(0.99)PEPIY(0.008)NS(0.011)EGK;T(0.002)GDLGIPPNPEDRS(0.961)PS(0.85)PEPIY(0.144)NS(0.043)EGK;T(0.003)GDLGIPPNPEDRS(0.955)PS(0.811)PEPIY(0.087)NS(0.144)EGK;T(0.003)GDLGIPPNPEDRS(0.963)PS(0.984)PEPIY(0.033)NS(0.017)EGK;TGDLGIPPNPEDRS(0.997)PS(0.983)PEPIY(0.018)NS(0.002)EGK;T(0.004)GDLGIPPNPEDRS(0.975)PS(0.927)PEPIY(0.033)NS(0.061)EGK;T(0.001)GDLGIPPNPEDRS(0.993)PS(0.978)PEPIY(0.012)NS(0.016)EGK;TGDLGIPPNPEDRS(0.979)PS(0.949)PEPIY(0.035)NS(0.036)EGK;T(0.004)GDLGIPPNPEDRS(0.995)PS(0.986)PEPIY(0.011)NS(0.004)EGK;T(0.003)GDLGIPPNPEDRS(0.982)PS(0.936)PEPIY(0.027)NS(0.051)EGK 77.062 0.00035005 89711500.0 675176.0 646347.0 671423.7 721095.8 715040.3 557415.1 595191.6 629424.3 475441.5 667357.9 True False 637652.4208636753 695919.7365668294 628225.0301328507 622881.3080803605 625210.5449726129 634193.9703145243 622869.1887497813 631255.820506197 570543.0849454431 648089.5434229398 0.9838955547652567 1.0738018282030448 0.9693491223679169 0.961103777096233 0.9646977818381552 0.9785591771238509 0.9610850770096443 0.9740256217870233 0.880346073679991 1.0 19.305833631570557 -5.407146368071195 7.174071662730428 0.9603150180331789 1.0284840359781113 0.3708032043458013 0.035440775403793846 0.2400425323042581 13.359398067259725 0.00878813164414881 0.01841207127607005 3.916098725712761e-06 5.407146368071195 0.06816901794493246 TGDLGIPPNPEDRSPS(ph)PEPIYNSEGK ddPTM_A459_Selumetinib_30min_R1 2 TGDLGIPPNPEDRSPSPEPIYNSEGK 26 1 Q15637-6;Q15637-4;Q15637-7;Q15637-3;Q15637-2;Q15637;Q15637-5 Q15637-6;Q15637-5 SF1 Splicing factor 1 1 TGDLGIPPNPEDRS(0.042)PS(0.951)PEPIY(0.002)NS(0.004)EGK;TGDLGIPPNPEDRS(0.292)PS(0.69)PEPIY(0.012)NS(0.006)EGK 80.554 7.7101e-05 22644000.0 3274.2 2943.0 5754.2 6086.200000000001 3841.8 4302.9 3820.5 4295.3 2630.7 2462.6000000000004 True False 3350.482489515844 2598.432191836419 4972.811245558102 5023.359422123501 3494.309868324881 4259.616732720607 3532.316609097803 4181.374690899269 4464.105761274034 2778.6986977553147 1.2057739445526883 0.9351255657677032 1.7896187339689738 1.8078100465449765 1.2575346406386738 1.5329538017783668 1.2712125326690782 1.5047960019116366 1.606545454129382 1.0 11.440193692133072 -9.999956635054115 15.088478826394264 1.0000000054579623 1.4362695296402677 0.20248945837511556 0.25872748062572215 0.0 0.0 0.2630564533387033 0.06380056133034338 1.0000998564632778e-10 9.999956635054115 0.43626952418230536 TGEDEDEEDNDALLKENES(ph)PDVR ddPTM_A459_Selumetinib_30min_R1 1 TGEDEDEEDNDALLKENESPDVR 23 1 A0A087WWS1;Q96FV9 A0A087WWS1 THOC1 THO complex subunit 1 1 TGEDEDEEDNDALLKENES(1)PDVR 74.047 0.020029 0.0 512.83 740.87 493.78 575.6 552.43 619.56 654.76 489.52 323.03 706.28 True False 524.7779412065271 654.128595978881 426.72738813939026 475.082265350184 502.4628040394383 613.327788915471 605.3709260496996 476.53633941494445 548.1583168222727 796.9379177497866 0.6584928756913419 0.8208024507427901 0.5354587586248709 0.5961345981524058 0.6304917771489394 0.7696054802452462 0.7596211857493359 0.5979591744868662 0.6878306385145262 1.0 9.638323531000447 -6.756027578394572 24.97988968804688 0.7376643647162957 0.6486965023013016 0.17712139184566134 0.11745494926342244 303.5888366632084 1401309.6689340384 0.03938372482940244 0.03829509943352559 1.7537691311594282e-07 6.756027578394572 -0.0889678624149941 TGEDEDEEDNDALLKENES(ph)PDVR ddPTM_A459_Selumetinib_30min_R2 2 TGEDEDEEDNDALLKENESPDVR 23 1 A0A087WWS1;Q96FV9 A0A087WWS1 THOC1 THO complex subunit 1 1 TGEDEDEEDNDALLKENES(1)PDVR;TGEDEDEEDNDALLKENES(1)PDVR 120.31 5.8337e-06 42595000.0 131025.0 82393.0 97134.0 100128.0 90891.0 104036.0 163415.0 153393.0 111492.0 85634.0 True False 123743.15503463261 88712.2781647488 90884.50419150291 86490.39366956566 79472.46000415036 118366.01465522153 171014.12130067928 153839.34823442175 133793.51534676173 83161.52391614746 1.4879856598034926 1.0667466634473681 1.0928672288778956 1.0400289652793608 0.9556397750031995 1.4233266669640527 2.056409181163087 1.8498861130724276 1.60883914875907 1.0 16.343628575048818 -6.9918812783743975 6.454271898654318 1.7062678349560558 1.1230638762881484 0.3940698829666246 0.28707569907999014 0.1254730850821838 23.752093097353697 0.10090613352964652 0.0856185826264812 1.0188698750276201e-07 6.9918812783743975 -0.5832039586679074 TGEDEDEEDNDALLKENES(ph)PDVRR ddPTM_A459_Selumetinib_30min_R2 2 TGEDEDEEDNDALLKENESPDVRR 24 2 A0A087WWS1;Q96FV9 A0A087WWS1 THOC1 THO complex subunit 1 1 TGEDEDEEDNDALLKENES(1)PDVRR;TGEDEDEEDNDALLKENES(1)PDVRR 53.718 0.0071873000000000015 13802300.0 57493.0 51935.0 61013.0 55056.0 54064.0 59924.0 52852.0 57258.0 41670.4 69728.0 True False 54297.7692227143 55918.24750265463 57087.49000593161 47557.27782310259 47271.99698170765 68177.9870640884 55309.72272425122 57424.61130042782 50005.64436825683 67714.77146489888 0.8018600380400085 0.8257909802094041 0.8430581506949912 0.7023176301754888 0.6981046521911679 1.0068406876249985 0.8168043918293658 0.8480366994990873 0.7384746826499757 1.0 16.047182960685042 -6.734460675485834 24.999954145244875 0.8684571200632389 0.7769201085828538 0.27096416304711846 0.08694599566569326 364.99632106530504 338224.8338497133 0.02912841529618289 0.029121181589646678 1.843059366828678e-07 6.734460675485834 -0.09153701148038518 TGEPSPPHDILHEPPDVVS(ph)DDEKDHGK ddPTM_A459_Selumetinib_30min_R2 1 TGEPSPPHDILHEPPDVVSDDEKDHGK 27 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 TGEPSPPHDILHEPPDVVS(1)DDEKDHGK 53.26600000000001 0.0060512 11124000.0 31140.0 27121.0 32415.0 32033.0 27354.0 20926.0 28223.0 25389.0 17148.0 30120.0 True False 29409.363463296788 29201.093492240238 30329.454190783494 27670.05013999283 23917.545972137286 23808.366552685296 29535.42542281356 25462.877786624776 20578.079155152525 29250.357338841644 1.0054360404084364 0.9983157865037091 1.036891749370491 0.9459730634897127 0.8176838899802806 0.8139513058553336 1.0097457983391325 0.8705151014621123 0.7035154790340571 1.0 14.836166629128423 -6.014233568366772 4.55920005059457 0.867418686066627 1.0105432100183662 0.37285970108941824 0.08427703884275073 0.214859591807368 11.432424374691294 0.025033969443125574 0.035190973942112416 9.677572457484134e-07 6.014233568366772 0.14312452395173925 TGFSVS(ph)VEK ddPTM_A459_Selumetinib_30min_R2 1 TGFSVSVEK 9 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 TGFS(0.005)VS(0.995)VEK 90.434 0.028549 4710900.0 21706.0 25170.0 24483.0 22582.0 23091.0 19015.0 22267.0 17394.0 15286.0 23288.0 True False 20499.66741600257 27100.458065693983 22907.790435074876 19506.292643877176 20190.10214384084 21634.143649016107 23302.459621223443 17444.61366026829 18343.62712652564 22615.614930509437 0.9064386477657804 1.1983073707686056 1.0129191934627115 0.8625143602689462 0.8927505268319511 0.9566020519667903 1.030370374311044 0.7713526125144072 0.8111045038080879 1.0 14.465031603691898 -5.611114660845612 5.259637547214512 0.9017485519059468 1.064613905980312 0.2829564570325377 0.09959053738798587 0.232658370326028 10.551779688308565 0.027373215686260468 0.048498560287792036 2.4484167344452904e-06 5.611114660845612 0.1628653540743651 TGGPAYGPSSDVS(ph)TASETESEKREEPNR ddPTM_A459_Selumetinib_30min_R1 1 TGGPAYGPSSDVSTASETESEKREEPNR 28 2 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TGGPAYGPS(0.03)S(0.107)DVS(0.319)T(0.293)AS(0.23)ET(0.016)ES(0.005)EKREEPNR 97.152 1.269e-06 16558000.0 545.93 867.48 1292.0 1395.7 1095.8 870.11 872.42 692.59 484.01 410.85 True False 558.6491068051388 765.9150383194888 1116.5534964479973 1151.9671955337938 996.6850834792027 861.3574833966696 806.6126570106279 674.2202633506213 821.3296193082627 463.5865995178962 1.205058790280181 1.65215094464766 2.4085111554327705 2.4849018430036036 2.149943688009314 1.858029296559548 1.7399395449511685 1.4543566704727275 1.7716854200755565 1.0 8.856695054030041 -8.488448796053182 0.700304953100699 1.0321526725166001 1.9922658581068793 0.3555913980993475 0.3676309850913405 0.8914137440503259 1.0036560815895899 0.4012454839667145 0.16011383325549955 3.247515285851168e-09 8.488448796053182 0.9601131855902791 TGGPAYGPSSDVS(ph)TASETESEKREEPNR ddPTM_A459_Selumetinib_30min_R2 1 TGGPAYGPSSDVSTASETESEKREEPNR 28 2 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TGGPAYGPS(0.002)S(0.008)DVS(0.406)T(0.406)AS(0.177)ET(0.001)ESEKREEPNR 92.449 9.326e-06 4743200.0 22024.0 22659.0 22077.0 22179.0 26019.0 18462.0 17666.0 15984.0 12993.0 25299.0 True False 20799.994249057425 24396.872439831557 20656.58985562016 19158.18193909096 22750.260607188728 21004.972918650295 18487.50400451491 16030.510793706342 15591.96305475255 24568.552135303944 0.8466105016896268 0.9930122176298012 0.8407735930819276 0.779784735933278 0.9259910995934347 0.8549536335300386 0.7524865080652909 0.6524808912394635 0.6346309285498177 1.0 14.584525219391788 -7.2641460889109455 3.8010839749582463 0.728092339075092 0.8771005206802658 0.19255203892060824 0.10778359409484153 0.2940839236132197 9.677837668024829 0.04461852581413026 0.031139134271285174 5.443195226727293e-08 7.2641460889109455 0.14900818160517382 TGGPAYGPSSDVSTAS(ph)ETESEKR ddPTM_A459_Selumetinib_30min_R1 3 TGGPAYGPSSDVSTASETESEKR 23 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TGGPAYGPSSDVS(0.001)T(0.017)AS(0.976)ET(0.004)ES(0.001)EKR;TGGPAYGPSSDVST(0.003)AS(0.996)ET(0.001)ESEKR;TGGPAYGPSSDVS(0.022)T(0.047)AS(0.93)ET(0.001)ESEKR 182.35 2.8335e-17 92282000.0 10681.0 12872.8 8776.0 9252.2 9532.7 9707.5 12874.699999999999 11321.6 6570.700000000001 12033.599999999999 True False 10929.846518391894 11365.64659159764 7584.267403117362 7636.476955303976 8670.46896813488 9609.851363704787 11903.551013519567 11021.31439026032 11149.997995059606 13578.229777190109 0.8049537161871279 0.837049216142346 0.5585608380157239 0.5624059307150917 0.6385566535853067 0.7077396333245334 0.8766644259854983 0.8116900782438432 0.8211672786529466 1.0 13.729007784158602 -7.194456171787637 4.284020868786355 0.8622981630932175 0.6757305079094554 0.48301273445641046 0.09717307556631369 0.2320699061807631 8.42088499237788 0.04264069389177888 0.03198372865914669 6.390632271973096e-08 7.194456171787637 -0.18656765518376206 TGGPAYGPSSDVSTAS(ph)ETESEKR ddPTM_A459_Selumetinib_30min_R2 4 TGGPAYGPSSDVSTASETESEKR 23 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TGGPAYGPSSDVS(0.002)T(0.013)AS(0.946)ET(0.028)ES(0.011)EKR;TGGPAYGPSSDVS(0.02)T(0.082)AS(0.89)ET(0.005)ES(0.002)EKR;T(0.001)GGPAY(0.018)GPS(0.013)S(0.025)DVS(0.051)T(0.116)AS(0.644)ET(0.062)ES(0.07)EKR;TGGPAYGPSSDVS(0.008)T(0.095)AS(0.895)ET(0.001)ESEKR 129.62 4.2255000000000005e-06 137696000.0 156934.6 101927.1 127301.1 140212.0 137413.1 137035.9 150018.6 149079.1 114522.5 131127.1 True False 148212.80319097944 109744.58082271741 119110.68582095757 121114.88372080863 120150.0378892995 155911.3513369553 156994.7621562164 149512.8954996263 137430.20002600623 127341.11991387884 1.1639037201119025 0.8618157347519637 0.9353670354203927 0.9511058470564652 0.9435289871061078 1.2243598253447008 1.232867767005602 1.1741132448084506 1.0792287685152342 1.0 16.95833883174901 -6.7529268798983235 24.999997493268264 1.1586681175639408 0.9619695561611534 0.43254376632615055 0.09670559216644102 155.57553647087886 456902.6079778153 0.03141143849024197 0.030930026503507037 1.766335185128377e-07 6.7529268798983235 -0.1966985614027874 TGGPAYGPSSDVSTAS(ph)ETESEKREEPNR ddPTM_A459_Selumetinib_30min_R1 2 TGGPAYGPSSDVSTASETESEKREEPNR 28 2 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TGGPAYGPS(0.04)S(0.035)DVS(0.166)T(0.143)AS(0.597)ET(0.018)ES(0.001)EKREEPNR;TGGPAYGPS(0.015)S(0.02)DVS(0.15)T(0.15)AS(0.5)ET(0.156)ES(0.008)EKREEPNR 91.767 1.2004e-05 33679000.0 5022.42 5781.05 9613.58 9886.519999999999 6558.92 5985.129999999999 5903.77 5836.17 3556.0899999999997 3854.26 True False 5139.432614071888 5104.201978462767 8308.108639614975 8160.024874965076 5965.6668440713765 5924.9250262632395 5458.443875747507 5681.375813048121 6034.425003462573 4348.991814671645 1.1817526528179776 1.1736517786130027 1.9103527883375075 1.876302651901213 1.3717355879920856 1.3623674816482907 1.2551055758102472 1.3063661775314406 1.387545725679454 1.0 12.086465278140146 -6.508454808258466 23.232837123498797 1.290540414883795 1.5473889070122149 0.208289965409027 0.24774691024527343 491.75478551350795 792078.6287178779 0.08542966996064645 0.09320863824490859 3.101310087341417e-07 6.508454808258466 0.25684849212842 TGIPS(ph)GDELDSFETNTEPDFNISR ddPTM_A459_Selumetinib_30min_R1 2 TGIPSGDELDSFETNTEPDFNISR 24 0 Q8N1W1-5;Q8N1W1-4;Q8N1W1-3;Q8N1W1;Q8N1W1-6;Q8N1W1-2 Q8N1W1-5 ARHGEF28 Rho guanine nucleotide exchange factor 28 1 T(0.051)GIPS(0.949)GDELDSFETNTEPDFNISR;T(0.04)GIPS(0.96)GDELDSFETNTEPDFNISR 148.9 9.1607e-10 13225500.0 2446.8 2659.3 2897.7 3120.8 2802.9 2554.0 2685.0 2830.6000000000004 1386.58 2271.0 True False 2503.8056793559863 2347.9479197249716 2504.208255926752 2575.8108646713918 2549.378189892187 2528.3090788464597 2482.468288294097 2755.5232929153885 2352.9249882036556 2562.5049714132715 0.9770930036381895 0.9162705812937535 0.9772501063854062 1.0051925336366399 0.9948773634909888 0.9866552873269345 0.9687662330367958 1.0753240768917078 0.91821284815146 1.0 11.323339088197757 -5.4910980043438515 7.7321573200908 0.994467085755372 0.94651364007472 0.17961164102439509 0.0388204606493894 0.3605145922004463 74.94203096081549 0.00953384702767285 0.019277716957270787 3.2277656511397243e-06 5.4910980043438515 -0.04795344568065196 TGLDAS(ph)PLAADTSYYQGVYSR ddPTM_A459_Selumetinib_30min_R1 1 TGLDASPLAADTSYYQGVYSR 21 0 Q9Y261;Q9Y261-2 Q9Y261 FOXA2 Hepatocyte nuclear factor 3-beta 1 T(0.267)GLDAS(0.733)PLAADTSYYQGVYSR 239.0 5.3713e-31 8863600.0 2252.3 2975.5 2039.7 1984.3 2050.8 2371.5 2555.3 2561.3 1660.1 2815.8 True False 2304.774207787104 2627.1270767275782 1762.719943270109 1637.7792549242006 1865.3055020981471 2347.644863149717 2362.5516637161672 2493.366003725072 2817.0684510932574 3177.235358214658 0.7254024168616188 0.8268594487138672 0.5547967791283209 0.5154730670769371 0.5870844592218984 0.7388954856869332 0.7435872377561997 0.7847596172812757 0.8866414141495063 1.0 11.633556248352926 -8.115874522109873 0.9123575948929522 0.9939985987617138 0.6481014808009143 0.6375823875769184 0.08658115272244783 0.39354101870369096 0.6501623999365753 0.09192767906012594 0.03428382153105428 7.65817837735149e-09 8.115874522109873 -0.34589711796079947 TGLDAS(ph)PLAADTSYYQGVYSR ddPTM_A459_Selumetinib_30min_R2 2 TGLDASPLAADTSYYQGVYSR 21 0 Q9Y261;Q9Y261-2 Q9Y261 FOXA2 Hepatocyte nuclear factor 3-beta 1 T(0.009)GLDAS(0.983)PLAADT(0.005)S(0.002)Y(0.001)YQGVYSR;T(0.003)GLDAS(0.997)PLAADTSYYQGVYSR 171.3 1.7087000000000003e-10 12047500.0 43520.0 41036.0 47584.0 52084.0 48761.0 42919.0 51506.0 59406.0 51157.0 42018.0 True False 41101.33262436342 44183.32924846318 44522.49724554194 44990.06935008852 42635.207251129155 48830.702670109 53901.1310572028 59578.86162480731 61389.82944600758 40804.83116412514 1.0072663322400648 1.0827965215870898 1.0911084784657876 1.1025672222274248 1.044856847456172 1.196689246763507 1.3209497385346785 1.460093325350846 1.504474536338246 1.0 15.316452352430089 -7.095990183224744 2.4007833326153185 1.36412382815722 1.0701440553965893 0.44924473664555686 0.13018309777648238 0.24036165566215478 2.7203952004596785 0.05450375349303497 0.04053182377532577 8.016961846916553e-08 7.095990183224744 -0.2939797727606308 TGLLFS(ph)PDVDEKLPK ddPTM_A459_Selumetinib_30min_R1 1 TGLLFSPDVDEKLPK 15 1 Q6P4F7-3;Q6P4F7;H3BQ41;H3BR51;Q6P4F7-2 Q6P4F7-3 ARHGAP11A Rho GTPase-activating protein 11A 1 T(0.001)GLLFS(0.999)PDVDEKLPK 105.9 0.0025397 10461000.0 3574.0 4328.0 5914.5 6363.9 4292.8 4128.1 4110.9 4320.6 2734.2 3816.7 True False 3657.267246206594 3821.2757479673883 5111.343386022973 5252.564330198115 3904.516997955395 4086.5750620149065 3800.8115032954197 4206.00365271329 4639.737701933123 4306.610622806267 0.8492217120440415 0.8873046770774401 1.1868598844193459 1.2196515520540483 0.906633392226934 0.9489074866378374 0.8825528556419017 0.9766389444264594 1.0773524955710494 1.0 12.07233717454305 TGLSLWDT(ph)SPSYIDK ddPTM_A459_Selumetinib_30min_R1 2 TGLSLWDTSPSYIDK 15 0 E7EPP6;O14757-2;O14757-3;O14757 E7EPP6 CHEK1 Serine/threonine-protein kinase Chk1 1 TGLSLWDT(0.841)S(0.155)PS(0.004)YIDK;TGLSLWDT(0.623)S(0.368)PS(0.009)YIDK 224.34 1.4797000000000002e-09 21829000.0 4824.299999999999 5185.6 5491.299999999999 6061.1 4840.6 4467.5 5393.6 5043.5 2627.5 4185.7 True False 4936.696803546298 4578.4675412799625 4745.61162155177 5002.642665938151 4402.768584677343 4422.56100616545 4986.756409587729 4909.7299964031545 4458.675594992791 4722.975367170641 1.0452514399844708 0.9694032226178542 1.0047927953506752 1.0592142192211027 0.9322023179034443 0.9363929858509598 1.055850607278333 1.039541732639692 0.9440395615833621 1.0 12.205480295747975 -10.955378339863177 15.301483413964565 0.999999955266392 0.9987489567101514 6.539671370486833e-05 0.047906907889340315 0.0 0.0 0.04696524753894326 0.011390745666843704 1.1082089675957613e-11 10.955378339863177 -0.0012509985562405568 TGLSLWDTS(ph)PSYIDK ddPTM_A459_Selumetinib_30min_R2 1 TGLSLWDTSPSYIDK 15 0 E7EPP6;O14757-2;O14757-3;O14757 E7EPP6 CHEK1 Serine/threonine-protein kinase Chk1 1 TGLSLWDT(0.204)S(0.771)PS(0.024)Y(0.001)IDK 88.706 0.031713 0.0 14248.0 12977.0 14340.0 14513.0 14584.0 14213.0 13696.0 11608.0 10008.0 13479.0 True False 13456.153199263083 13972.294172368322 13417.380012211486 12536.30436367857 12751.827537385767 16170.71173723197 14332.891138109138 11641.77735819215 12009.879646883988 13089.826247352148 1.0279856237194163 1.0674163207624456 1.025023538026381 0.9577135805155896 0.9741785182187004 1.2353648880941437 1.0949642009960554 0.8893760037912716 0.9174972547334909 1.0 13.676158326813727 -7.762159495700195 24.999990977508656 0.9275774579248774 1.054139882750421 0.33487438117913404 0.07662575129782963 23.139806735414908 803220.4226170185 0.04227317072889236 0.02219573093239243 1.7291811966077842e-08 7.762159495700195 0.12656242482554347 TGNESGSNLS(ph)DSGSVK ddPTM_A459_Selumetinib_30min_R1 1 TGNESGSNLSDSGSVK 16 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 TGNESGS(0.037)NLS(0.556)DS(0.404)GS(0.003)VK 194.1 1.1931e-06 6850400.0 3560.7 4250.5 4503.3 4683.1 4111.3 3551.3 3987.4 3584.5 2046.6 3122.9 True False 3643.6573820838908 3752.8494839961577 3891.7765948562446 3865.284497674506 3739.4336409089706 3515.5771463224096 3686.6272077258404 3489.4274159030615 3472.9307222501384 3523.7546346219756 1.0340269853876414 1.0650144159083197 1.1044402912218518 1.0969221465356567 1.0612071578900195 0.9976793252801374 1.0462213150437865 0.9902583402426381 0.985576773174705 1.0 11.782897754965196 -6.67247385008668 4.443957024047305 1.0059277419547341 1.0767071053316994 0.6782051062266103 0.023618383034210478 0.1381628703481829 4.920951927091033 0.008595676827162531 0.00848284572909145 2.125818341989168e-07 6.67247385008668 0.07077936337696533 TGNESGSNLSDS(ph)GSVK ddPTM_A459_Selumetinib_30min_R2 2 TGNESGSNLSDSGSVK 16 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 TGNESGSNLS(0.112)DS(0.886)GS(0.002)VK;TGNESGSNLS(0.06)DS(0.92)GS(0.02)VK 167.97 1.3832e-05 19683500.0 93840.0 76516.0 98316.0 103622.0 101755.0 69450.0 71856.0 76646.0 72445.0 86318.0 True False 88624.74847128359 82384.53116228226 91990.45559836729 89508.50484207952 88971.62719875811 79016.10709567017 75197.44637996277 76869.02717057167 86936.02428242489 83825.775058902 1.0572493771636406 0.982806673775375 1.0974005970565521 1.0677921531794299 1.0613874686662934 0.9426230421388623 0.8970683101602538 0.9170094415060044 1.037103733563303 1.0 16.355106296888103 -6.761989816313168 24.99913741773269 0.9497181958067965 1.0526615783352478 0.507889287189834 0.04611303577853705 11.852068999617545 538272.0444284332 0.01609680132510878 0.015060826355488747 1.7298569218180147e-07 6.761989816313168 0.10294338252845125 TGPLSTS(ph)SPSRR ddPTM_A459_Selumetinib_30min_R2 1 TGPLSTSSPSRR 12 1 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 TGPLS(0.008)T(0.008)S(0.768)S(0.174)PS(0.041)RR 63.727 0.042911000000000005 3462200.0 13326.0 11883.0 14505.0 10460.0 13620.0 9809.7 14359.0 16386.0 12222.0 17657.0 True False 12585.39426820466 12794.387890132755 13571.764091849896 9035.329955493547 11908.933835655116 11160.897131409582 15026.721951818718 16433.680547151664 14666.741511212636 17147.19653160448 0.7339622103827973 0.7461504197815112 0.7914858890685365 0.5269275323718531 0.6945120045545302 0.6508875728366802 0.8763369524646518 0.9583887673336154 0.8553434075465312 1.0 14.065685102853434 -7.371343814142973 4.265493189951081 0.927842243784889 0.6907255311073848 0.7022383371479375 0.07451727079970362 0.13956365917637023 4.273524770345513 0.03386715969771173 0.022179011446019727 4.2526161666401307e-08 7.371343814142973 -0.23711671267750423 TGPLSTSS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 TGPLSTSSPSR 11 0 Q8IY92;Q8IY92-2 Q8IY92 SLX4 Structure-specific endonuclease subunit SLX4 1 TGPLS(0.006)T(0.001)S(0.006)S(0.985)PS(0.002)R 92.943 0.024296 6068400.0 42693.0 32968.0 49363.0 41550.0 46500.0 33638.0 43486.0 45860.0 29259.0 49957.0 True False 40320.293973620115 35496.539591172026 46187.038322370674 35890.818322252075 40658.2542847256 38271.32916463863 45508.18516587428 45993.44500746833 35111.61756476605 48514.6116061259 0.831095883049982 0.7316669847706233 0.952023252238892 0.7397939947172569 0.8380620381920508 0.7888619097963908 0.9380304955410176 0.948032839691141 0.7237328384657733 1.0 15.566131702456078 -7.255202806622737 24.838754623879648 0.8981184470518996 0.8139117472580111 0.19543518451043207 0.0881550159666977 809.2262736086908 3222960.4101741454 0.03274923280199364 0.02474530725541558 5.556447219783549e-08 7.255202806622737 -0.0842066997938885 TGPPPIS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 3 TGPPPISPSK 10 0 A0A075B6E4;A0A0A6YYI5;G5E9M7;Q14135-2;Q14135;Q14135-4;F8W708;E7ERW0;E7EQU6;E7EWF5;A0A096LP98;E7EUJ2;F8WBN7 A0A075B6E4 VGLL4 Transcription cofactor vestigial-like protein 4 1 TGPPPIS(0.879)PS(0.121)K;TGPPPIS(0.967)PS(0.033)K;T(0.068)GPPPIS(0.738)PS(0.193)K 128.57 0.0030962 80104000.0 408683.0 327902.0 338742.0 361146.0 319212.0 246022.0 281196.0 281765.0 210336.0 325173.0 True False 385970.0349476722 353051.0290288916 316947.7085144027 311957.29178840044 279109.7347685123 279909.2973346434 294272.17117930367 282584.8895012931 252409.077278876 315784.410589082 1.2222580406286112 1.118012850508644 1.003683835826951 0.9878805961524756 0.8838616645066338 0.8863936532284314 0.9318768163075303 0.8948664976024097 0.7993082267994734 1.0 18.268580425492573 -4.96814974745412 0.7946808962792286 0.891355107301398 1.36363854000876 0.8232134920280638 0.04947527922566316 0.778307093161466 0.4526204072532019 0.019030557758044936 0.3099720062753075 1.0760941056741197e-05 4.96814974745412 0.47228343270736206 TGPPPISPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 TGPPPISPSK 10 0 A0A075B6E4;A0A0A6YYI5;G5E9M7;Q14135-2;Q14135;Q14135-4;F8W708;E7ERW0;E7EQU6;E7EWF5;A0A096LP98;E7EUJ2;F8WBN7 A0A075B6E4 VGLL4 Transcription cofactor vestigial-like protein 4 1 TGPPPIS(0.176)PS(0.824)K 103.46 0.014196 43269000.0 174060.0 156380.0 136580.0 164330.0 119800.0 108880.0 125770.0 127760.0 87281.0 133780.0 True False 164386.4420173872 168373.84315904713 127792.59149706026 141947.9705149381 104749.65297441126 123877.23168576765 131618.55420852723 128131.76044819353 104739.63883489993 129917.42379781668 1.2653148223845074 1.296006634345506 0.9836447472660543 1.092601487663763 0.8062787108327161 0.9535074516144266 1.0130939358323325 0.9862553974869293 0.8062016300284746 1.0 16.98723540438347 -5.337015073664515 1.6902421273186454 0.9417319402702633 1.3126860948343206 0.6877760271667754 0.0866264881547108 0.2406615150965078 1.2155660577238758 0.024968574152389584 0.10039817681582935 4.602405990915282e-06 5.337015073664515 0.37095415456405734 TGQAGSLS(ph)GSPKPFSPQLSAPITTK ddPTM_A459_Selumetinib_30min_R1 1 TGQAGSLSGSPKPFSPQLSAPITTK 25 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 T(0.009)GQAGS(0.054)LS(0.509)GS(0.403)PKPFS(0.014)PQLS(0.008)APIT(0.002)T(0.001)K 57.484 0.0057691 133970000.0 1308.0 1082.0 1877.0 1977.6 1288.8 1425.4 1147.0 1137.2 728.46 1002.5 True False 1338.4738550750492 955.3189369918471 1622.113709622981 1632.2492841496241 1172.2282675561212 1411.06177015965 1060.4808665450016 1107.0377618538053 1236.1434153866594 1131.1806401769284 1.1832538566658088 0.8445326087285452 1.4340005937241516 1.4429607669861848 1.0362874203476224 1.2474239038770547 0.937499130447575 0.9786569205079864 1.0927904628860283 1.0 10.143613618833152 -7.259300484004073 24.971645960871477 1.0004580367515203 1.196507222144226 0.2457467476719355 0.16805705497718573 301.4720982248479 3519715.0627623815 0.07010818439075699 0.05161999024094122 5.50426729883352e-08 7.259300484004073 0.19604918539270555 TGQAGSLSGS(ph)PKPFSPQLSAPITTK ddPTM_A459_Selumetinib_30min_R1 1 TGQAGSLSGSPKPFSPQLSAPITTK 25 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 T(0.001)GQAGS(0.016)LS(0.088)GS(0.742)PKPFS(0.099)PQLS(0.044)APIT(0.007)T(0.003)K 56.972 0.0061131 144270000.0 1367.5 1709.8 2214.8 2009.2 1374.6 1376.5 1383.3 1528.3 953.31 1327.9 True False 1399.360089308203 1509.6158211355446 1914.0423250255617 1658.3309373550887 1250.2676727053415 1362.653659762001 1278.9565672987812 1487.7645193819653 1617.6974429924164 1498.3488998413402 0.9339347394030729 1.0075195578916216 1.2774343313685077 1.1067722194281244 0.8344302671011619 0.9094368206939599 0.8535772725793103 0.9929359707472034 1.0796533725647706 1.0 10.549157888072587 -6.23788630850582 24.12862462389261 0.9383025532072264 1.0901383460737712 0.28215951068866385 0.10590297967117998 669.654341296947 686017.4034317461 0.033498610633691125 0.04321727925841006 5.782474037082619e-07 6.23788630850582 0.1518357928665448 TGQAGSLSGS(ph)PKPFSPQLSAPITTK ddPTM_A459_Selumetinib_30min_R2 1 TGQAGSLSGSPKPFSPQLSAPITTK 25 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 T(0.006)GQAGS(0.038)LS(0.074)GS(0.762)PKPFS(0.043)PQLS(0.071)APIT(0.005)T(0.002)K 47.208 0.030059 116500000.0 42553.0 40163.0 37407.0 38512.0 39841.0 30350.0 34600.0 34162.0 20741.0 30613.0 True False 40188.07461315571 43243.37295560061 35000.274345662125 33266.5991630944 34835.81739694092 34530.43701013089 36208.968558599314 34261.40576417645 24889.779551960484 29729.123147873834 1.3518082727586225 1.4545794956853035 1.177305976081749 1.1189902573858306 1.1717741294846198 1.161502034162768 1.2179628836846104 1.152452616707155 0.8372187577870271 1.0 14.859589291538038 -1.5228787452937889 0.19047125641179463 0.9585085459951301 3.028921823272836 0.6064080273405379 0.1009077916617464 39.59367078767806 0.46352853855720383 0.21349871965434283 24.110182562018124 0.02999999999907082 1.5228787452937889 2.070413277277706 TGQAGSLSGSPKPFS(ph)PQLSAPITTK ddPTM_A459_Selumetinib_30min_R2 1 TGQAGSLSGSPKPFSPQLSAPITTK 25 1 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;A0A087WYS3;Q9ULU4-8;Q9ULU4-17;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 T(0.002)GQAGS(0.007)LS(0.005)GS(0.004)PKPFS(0.971)PQLS(0.009)APIT(0.001)TK 66.77 0.0010627 5699800.0 24379.0 27695.0 24975.0 28456.0 26877.0 16133.0 19514.0 24339.0 14369.0 25495.0 True False 23024.112776869366 29819.117446539312 23368.13569072397 24580.243710661976 23500.470976571414 18355.17430920731 20421.439666257444 24409.822460461637 17243.201503404864 24758.89310603481 0.9299330417666125 1.2043800713882118 0.9438279647900797 0.9927844352892622 0.9491729244892347 0.7413568219951384 0.8248123039587686 0.9859012014762449 0.696444765505367 1.0 14.595659197085055 -6.2272084775804615 1.6552931524009884 0.84914323634967 1.0446041463907636 0.31740468958194146 0.11355584097945647 0.4130049177956692 2.2423922566300942 0.039106659834739356 0.05403981813689432 5.926407665718816e-07 6.2272084775804615 0.19546091004109356 TGQLEGAPAPGPAAS(ph)PQTLDHSGATATGGASELK ddPTM_A459_Selumetinib_30min_R1 1 TGQLEGAPAPGPAASPQTLDHSGATATGGASELK 34 0 P55317-2;P55317 P55317-2 FOXA1 Hepatocyte nuclear factor 3-alpha 1 TGQLEGAPAPGPAAS(0.73)PQT(0.269)LDHS(0.001)GATATGGASELK 134.57 1.0855e-25 21415000.0 2846.8 3326.9 3023.7 3168.2 3147.5 3029.2 3398.1 3458.4 1586.6 2840.8 True False 2913.124901091475 2937.385001366151 2613.098147995209 2614.9333444795907 2862.8091807362575 2998.7289982935395 3141.778581173995 3366.6719975335895 2692.3443193208604 3205.4443517352784 0.9088053266357423 0.9163737313910901 0.8152062120749652 0.8157787369055362 0.8931083701972445 0.9355111707586398 0.9801382387041542 1.050298064201623 0.8399285789701357 1.0 11.646308647624478 -6.805878639874364 2.5979180580858316 0.9703654656973527 0.8639026432447241 0.39068444936071944 0.05849219625371165 0.28706616298863097 3.9623915288156697 0.02258164530422477 0.02037047296888458 1.5635845128068872e-07 6.805878639874364 -0.10646282245262861 TGQLEGAPAPGPAAS(ph)PQTLDHSGATATGGASELK ddPTM_A459_Selumetinib_30min_R2 4 TGQLEGAPAPGPAASPQTLDHSGATATGGASELK 34 0 P55317-2;P55317 P55317-2 FOXA1 Hepatocyte nuclear factor 3-alpha 1 TGQLEGAPAPGPAAS(0.943)PQT(0.056)LDHS(0.001)GATATGGASELK;TGQLEGAPAPGPAAS(0.495)PQT(0.479)LDHS(0.023)GAT(0.003)ATGGASELK;TGQLEGAPAPGPAAS(0.913)PQT(0.085)LDHS(0.001)GATATGGASELK;TGQLEGAPAPGPAAS(0.835)PQT(0.163)LDHS(0.001)GATATGGASELK 109.56 2.3822e-14 86841300.0 215096.0 174525.8 205518.3 217642.9 234068.7 172519.3 169914.8 208956.5 149484.6 185263.9 True False 203141.82541751058 187911.367671104 192295.47632940608 187999.56156505615 204662.897305272 196282.26760072052 177816.17487978886 209564.52882038904 179385.69694870056 179914.84983357956 1.129099824752742 1.0444461246246277 1.0688138111294234 1.0449363225934654 1.1375542235373248 1.0909731341369584 0.988335176580855 1.1647983977655836 0.9970588704302704 1.0 17.45695474327801 TGQLEGAPAPGPAASPQT(ph)LDHSGATATGGASELK ddPTM_A459_Selumetinib_30min_R1 1 TGQLEGAPAPGPAASPQTLDHSGATATGGASELK 34 0 P55317-2;P55317 P55317-2 FOXA1 Hepatocyte nuclear factor 3-alpha 1 TGQLEGAPAPGPAAS(0.488)PQT(0.49)LDHS(0.02)GAT(0.001)ATGGASELK 106.21 8.1036e-14 27844000.0 5294.7 5640.2 5105.7 5683.8 5519.4 4507.6 6513.8 5457.9 2455.4 5250.1 True False 5418.056208307231 4979.842761942156 4412.373983602589 4691.231028139984 5020.171244529214 4462.25763657334 6022.458821709537 5313.138762242244 4166.634464679464 5924.00147530463 0.9145940005068312 0.8406214587726918 0.7448299940498734 0.7919024071307725 0.8474291009981665 0.7532505950876519 1.0166200745923757 0.8968834299571181 0.703347978903939 1.0 12.532356284575547 -7.228497611419931 24.99986567112715 0.8956199466996955 0.8137575371465847 0.18233455694209288 0.09133429384686481 1241.5661949978605 942239.2229450814 0.03503084650872139 0.027133003985185672 5.9088421537517676e-08 7.228497611419931 -0.08186240955311075 TGQPAQPAPSAQQPPRPPAS(ph)PDEPSVAASSVGSSR ddPTM_A459_Selumetinib_30min_R1 3 TGQPAQPAPSAQQPPRPPASPDEPSVAASSVGSSR 35 1 O94964-2 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 TGQPAQPAPS(0.009)AQQPPRPPAS(0.927)PDEPS(0.033)VAAS(0.022)S(0.009)VGSSR;TGQPAQPAPS(0.099)AQQPPRPPAS(0.707)PDEPS(0.062)VAAS(0.027)S(0.029)VGS(0.038)S(0.038)R;T(0.001)GQPAQPAPS(0.192)AQQPPRPPAS(0.472)PDEPS(0.264)VAAS(0.047)S(0.008)VGS(0.008)S(0.008)R 75.779 3.2349e-06 46690000.0 2467.26 2891.54 3396.99 3697.8599999999997 2796.21 2466.26 2788.5600000000004 2830.29 1788.7299999999998 2321.27 True False 2524.7423575477574 2552.9971525595242 2935.697416330406 3052.0981684291683 2543.293299210971 2441.4516635849154 2578.216674117466 2755.2215151224123 3035.3441663297626 2619.227615584536 0.9639262897677977 0.9747137428488699 1.1208256200655715 1.1652664893532088 0.9710088898262402 0.932126573902228 0.9843423529810648 1.0519213751140626 1.1588699463419339 1.0 11.354925722588941 -5.041078701397764 22.87043822638097 1.0451096698645137 0.9666230137489319 0.14762983023127418 0.07559715155408132 341.50249302818787 190131.46385790926 0.021181922474942556 0.056067780645021485 9.097483961229205e-06 5.041078701397764 -0.07848665611558181 TGQPAQPAPSAQQPPRPPAS(ph)PDEPSVAASSVGSSR ddPTM_A459_Selumetinib_30min_R2 1 TGQPAQPAPSAQQPPRPPASPDEPSVAASSVGSSR 35 1 O94964-2 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 TGQPAQPAPS(0.03)AQQPPRPPAS(0.889)PDEPS(0.045)VAAS(0.026)S(0.01)VGSSR 61.382 0.00016951 40035000.0 49197.0 41836.0 55482.0 53710.0 44103.0 37832.0 37160.0 36328.0 31317.0 54011.0 True False 46462.827691194994 45044.68667605775 51912.34852423415 46394.60534508205 38562.38685417749 43043.01459529725 38888.01363114308 36433.708465575866 37581.27507009049 52451.562092568936 0.8858235262697277 0.8587863712535541 0.9897197805590011 0.8845228529743825 0.7351999695666033 0.8206240744428728 0.7414081121647382 0.6946162709372883 0.716494868232243 1.0 15.678698118789438 -6.166659792244947 5.236878940589771 0.7693349123196968 0.9103188303545758 0.30576272955847206 0.08714496255348028 0.2435123734235185 10.5096639361395 0.02501115623957101 0.03255837464554775 6.813028532752599e-07 6.166659792244947 0.14098391803487909 TGRDT(ph)PENGETAIGAENSEK ddPTM_A459_Selumetinib_30min_R1 2 TGRDTPENGETAIGAENSEK 20 1 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 T(0.4)GRDT(0.6)PENGETAIGAENSEK;TGRDT(1)PENGETAIGAENSEK 158.67 1.712e-06 95633000.0 9487.9 10278.5 6972.2 7151.2 7589.1 8347.8 9776.2 10391.7 5615.1 9867.9 True False 9708.949609760368 9075.088441654992 6025.4135355531935 5902.377164649467 6902.66724496443 8263.828711195954 9038.77336313623 10116.078359001214 9528.41458932218 11134.541086485688 0.8719667505241324 0.8150392882082664 0.5411461046083355 0.5300961322791607 0.6199328011230203 0.7421795516319932 0.8117778086163648 0.9085312345094662 0.8557527890293647 1.0 13.442754477783382 -7.40894822077383 1.7081966735442606 0.9187946075408495 0.6696737888218333 0.5017832213258409 0.10630790619805283 0.3613148927588112 2.0507516265073855 0.07144133173033246 0.03870130945964296 3.899884807004168e-08 7.40894822077383 -0.24912081871901626 TGRDT(ph)PENGETAIGAENSEK ddPTM_A459_Selumetinib_30min_R2 2 TGRDTPENGETAIGAENSEK 20 1 Q8N3X1-2;Q8N3X1 Q8N3X1-2 FNBP4 Formin-binding protein 4 1 T(0.003)GRDT(0.997)PENGETAIGAENSEK;T(0.101)GRDT(0.899)PENGETAIGAENSEK 153.77 7.4652e-06 109209300.0 117610.0 89199.0 97828.0 110963.0 112725.0 95347.0 119878.0 115120.0 91231.0 88402.0 True False 111073.70703013294 96040.27648000933 91533.85298707278 95849.64797814809 98563.47772571396 108480.18377611038 125452.56453375072 115454.98014085817 109479.74920712141 85849.60456401996 1.2938173401521356 1.1187037723439943 1.0662117018700297 1.1164832786931578 1.1480947201359908 1.263607262107006 1.461306259601906 1.344851624269985 1.275250477426252 1.0 16.38952386852536 -6.82067527616216 4.241012357890521 1.3064434537624985 1.1398379421496925 0.16736453278294705 0.12282062687724307 0.27793213496963054 10.070812984305338 0.04302427134467241 0.0386282297911835 1.5112096697601606e-07 6.82067527616216 -0.166605511612806 TGS(ph)AGEAFLSTIQK ddPTM_A459_Selumetinib_30min_R2 1 TGSAGEAFLSTIQK 14 0 A0A1B0GV70;Q96N21-2 A0A1B0GV70 ENTHD2 AP-4 complex accessory subunit tepsin 1 T(0.056)GS(0.944)AGEAFLSTIQK 154.69 8.3045e-05 0.0 20818.0 21075.0 21219.0 23035.0 20050.0 12602.0 17400.0 17840.0 8318.6 14549.0 True False 19661.018901056923 22691.384733194296 19853.792641500393 19897.593262408594 17531.13975072577 14337.811110433915 18209.134477445896 17891.911446429003 9982.552441104028 14128.932567158274 1.3915431195954322 1.6060225799321068 1.4051870194107345 1.4082870852295788 1.2407971845994716 1.0147837455011404 1.2887834513253866 1.266331434549947 0.7065326693049537 1.0 13.786364854546278 -6.6268043571411175 0.4639995675432207 0.9466289285120528 1.5737114506583882 0.6080086375201701 0.15438144232993628 0.877537525412353 0.389764875963927 0.14531411418917925 0.2364778695653814 2.3615418311860382e-07 6.6268043571411175 0.6270825221463354 TGS(ph)CSELDACPSK ddPTM_A459_Selumetinib_30min_R1 1 TGSCSELDACPSK 13 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 T(0.203)GS(0.79)CS(0.007)ELDACPSK 217.68 1.789e-08 37377000.0 3345.9 3789.8 4246.6 4729.9 2989.4 3172.4 3971.1 4300.3 2155.1 3232.8 True False 3423.8529600119314 3346.088454169779 3669.935044904078 3903.9117562193096 2719.009297821435 3140.4885363087346 3671.5567298490487 4186.242074656979 3657.047297723676 3647.7613701386254 0.9386175828387083 0.9172991636902549 1.0060787076004947 1.07022125629642 0.7453912199629729 0.8609358501401606 1.0065232775107542 1.1476194986126216 1.0025456510563073 1.0 11.832795638786965 -7.515630791483765 24.060210527516862 1.0604638345026403 0.925920022640276 0.29733210928028286 0.08882786746379263 264.95689988995315 879562.4780817562 0.042483696707599904 0.025844309892964632 3.050487210576889e-08 7.515630791483765 -0.1345438118623643 TGS(ph)CSELDACPSK ddPTM_A459_Selumetinib_30min_R2 1 TGSCSELDACPSK 13 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 T(0.472)GS(0.484)CS(0.044)ELDACPSK 203.85 4.9548e-05 51225000.0 146430.0 148600.0 137570.0 130330.0 127120.0 109020.0 117150.0 128820.0 78068.0 127720.0 True False 138292.00680573363 159997.14217569074 128718.89597489049 112578.82916820973 111150.04913278106 124036.5154149744 122597.70712832102 129194.84487270105 93683.78140217214 124032.39174358762 1.114966863588545 1.2899625648310733 1.0377845187488708 0.9076566821427111 0.896137271645634 1.0000332467295745 0.9884329843591784 1.0416218139192686 0.7553170594004571 1.0 16.92035741202659 -5.469568693313118 4.603261938149959 0.9466439714761469 1.1997479762650847 0.59451565272496 0.08535470092582538 0.13577395508478013 6.053617364553938 0.022126392804720254 0.046431805166817525 3.391808363196686e-06 5.469568693313118 0.2531040047889378 TGS(ph)ESS(ph)QTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 2 T(0.009)GS(0.586)ES(0.48)S(0.906)QT(0.018)GT(0.001)STTSSR 151.38 0.029042 24564000.0 52639.0 48990.0 48648.0 46327.0 42145.0 43316.0 49106.0 47004.0 31994.0 43897.0 True False 49713.53511061269 52747.375472322135 45518.040643937566 40017.18268146744 36850.36831891957 49282.38581650178 51389.52630169305 47140.77385806892 38393.69398705095 42629.57955189681 1.1661746522761725 1.2373421466216439 1.067757203387952 0.938718680834066 0.8644318969662442 1.156060799438707 1.2054898697542153 1.1058231010859545 0.9006350611624229 1.0 15.379567205872066 -5.363355629599502 5.0086319513538164 1.0333040659681725 1.2006532489327058 0.305786204618948 0.10441610377876334 0.2931289702412126 11.288700304560653 0.030522641068387594 0.06608541382427857 4.331560357597727e-06 5.363355629599502 0.16734918296453327 TGS(ph)ESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R1 6 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 TGS(0.482)ES(0.482)S(0.036)QT(0.001)GTSTTSSR;T(0.019)GS(0.972)ES(0.008)S(0.001)QTGTSTTSSR;T(0.001)GS(0.704)ES(0.129)S(0.129)QT(0.035)GT(0.002)STTSSR;TGS(0.894)ES(0.105)S(0.001)QTGTSTTSSR;T(0.066)GS(0.467)ES(0.467)SQTGTSTTSSR;T(0.027)GS(0.457)ES(0.457)S(0.058)QTGTSTTSSR 283.49 7.302899999999997e-63 177607020.0 4215.24 4954.889999999999 5529.47 5824.13 3178.79 4941.15 4502.49 4631.4 3918.7500000000005 4748.63 True False 4313.4468905707545 4374.769175334133 4778.5983452045775 4807.055027960328 2891.2690057609566 4891.446517205241 4162.863554324504 4508.560227092609 6649.832535824163 5358.162916073181 0.8050234675827916 0.8164681148852144 0.8918352092038764 0.8971461120639568 0.5396008018135946 0.9128961910680423 0.7769199293729814 0.8414376900650089 1.2410657607808617 1.0 12.387522731956158 -8.1743166345493 6.347900311131376 1.1180311221345063 0.8076085647866474 0.5456847354976261 0.11345421402241682 0.15957279969159147 9.376219860940362 0.0765893653776776 0.02820532722731199 6.693963892867576e-09 8.1743166345493 -0.31042255734785884 TGS(ph)ESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 8 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 T(0.101)GS(0.566)ES(0.246)S(0.085)QT(0.001)GTSTTSSR;T(0.04)GS(0.834)ES(0.127)SQTGTSTTSSR;T(0.001)GS(0.999)ESSQTGTSTTSSR;T(0.008)GS(0.897)ES(0.037)S(0.055)QT(0.002)GTSTTSSR;T(0.155)GS(0.42)ES(0.42)S(0.006)QTGTSTTSSR;T(0.03)GS(0.459)ES(0.459)S(0.052)QTGTSTTSSR;T(0.259)GS(0.733)ES(0.006)S(0.001)QTGTSTTSSR;T(0.072)GS(0.928)ESSQTGTSTTSSR 289.87 1.3528999999999999e-74 2265543160.0 1303006.0 1358018.4400000002 1201543.19 1131830.87 1180290.9000000004 879764.4199999999 1048770.5899999999 1064588.1 815148.6199999999 1228515.38 True False 1230590.1428662983 1462174.087630476 1124237.2092967124 977673.5529888466 1032012.2052074763 1000943.9831487419 1097540.5005344984 1067685.8751189518 978201.1211554296 1193044.9489131116 1.031470058179611 1.2255817259547066 0.9423259453224421 0.8194775510172749 0.8650237412661279 0.8389826251396667 0.919948993987511 0.8949251041141706 0.8199197541103468 1.0 20.18621696805927 -5.432010540192829 5.166650238533333 0.874974898949377 1.1254945921739623 0.6815725506313486 0.06690022346449605 0.10756406989726368 4.602365677736657 0.01645051023052701 0.03494731937324893 3.6981920427357897e-06 5.432010540192829 0.25051969322458534 TGS(ph)GQGPSSTGQPGR ddPTM_A459_Selumetinib_30min_R1 1 TGSGQGPSSTGQPGR 15 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 T(0.09)GS(0.908)GQGPS(0.001)STGQPGR 130.64 0.00093716 0.0 155.98 141.9 215.42 142.82 150.15 53.12 0.0 66.21600000000001 0.0 112.66 True False 159.61403051575388 125.28628203247969 186.16714721735883 117.87916806343509 136.56895901113558 52.58566102910101 0.0 64.45973658011921 0.0 127.1210084013294 1.25560701982352 0.9855670876755684 1.464487652816731 0.9272988748742677 1.0743224957748791 0.41366617280980505 0.0 0.5070738298158836 0.0 1.0 6.9900586639556925 -6.763560359285282 3.9452805672822127 0.3176053459416348 1.149606738414735 0.615600833324664 0.2983889661558381 0.1315314830746555 4.546681885015799 0.09927479686551954 0.09258890302029484 1.7236125225907382e-07 6.763560359285282 0.8320013924731002 TGS(ph)GSPFAGNSPAR ddPTM_A459_Selumetinib_30min_R1 1 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 T(0.048)GS(0.545)GS(0.286)PFAGNS(0.121)PAR 113.65 0.0032264000000000004 17965000.0 3941.4 4727.3 4626.5 5149.3 4296.3 4074.4 4221.3 4239.5 2410.9 4172.0 True False 4033.226951370642 4173.825518337853 3998.246711545402 4250.071419332351 3907.7004235733743 4033.415235259211 3902.8839424118732 4127.054688163213 4091.1212148308705 4707.516838721341 0.8567631491396109 0.8866299710298118 0.8493324290755822 0.902826599444891 0.8300980235335254 0.8568031455740411 0.8290748766544991 0.8766946204454165 0.8690614085922429 1.0 12.200750540010635 -9.20153299798263 1.5120031919248313 1.0000285368121649 0.8606407293989748 0.7830444419888494 0.02185481586196566 2.7825476931765256 5.740602161595316 0.02073357802199849 0.005942119955835318 6.28734080670901e-10 9.20153299798263 -0.13938780741319 TGS(ph)NAAQYK ddPTM_A459_Selumetinib_30min_R1 2 TGSNAAQYK 9 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 T(0.324)GS(0.676)NAAQYK;T(0.209)GS(0.791)NAAQYK 108.98 0.011693 451390000.0 11080.7 13088.1 16152.0 14861.9 9298.4 11182.0 10298.1 9268.7 6665.200000000001 8365.5 True False 11338.858750711082 11555.739167507387 13958.647116585182 12266.548157414687 8457.36136176585 11069.51923244366 9521.30602595212 9022.863967019317 11310.357593052686 9439.293411870414 1.2012402047437007 1.2242165449561542 1.4787809328006944 1.299519743923719 0.8959739879608222 1.1727063403414444 1.0086884272480152 0.9558834092043992 1.198220788309145 1.0 13.204463153852663 -6.235282358420183 21.929463809378824 1.0415849093758724 1.3081624122749322 0.5773316302881137 0.10988678163574746 117.87788342955723 98825.35082737375 0.03225126635728412 0.04160825419069709 5.817248838681152e-07 6.235282358420183 0.2665775028990598 TGS(ph)NAAQYK ddPTM_A459_Selumetinib_30min_R2 1 TGSNAAQYK 9 0 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 T(0.149)GS(0.851)NAAQYK 94.767 0.022974 142050000.0 294590.0 281330.0 214270.0 239820.0 213700.0 215380.0 254080.0 216990.0 151170.0 259170.0 True False 278217.86713720654 302907.106381473 200484.10147953627 207156.1022874247 186853.09549776057 245046.63997502445 265895.22344996844 217621.40497537193 181408.22404271094 251687.08869547094 1.1054117578269442 1.2035067350950839 0.7965609301560647 0.8230700405060247 0.7424023872906873 0.9736162520101255 1.0564515837031618 0.8646506505491951 0.720768891972071 1.0 17.941271683971927 -5.258294132748136 24.985448361953875 0.8711697523018573 1.1544592673746423 0.5293066025690223 0.10646934670401317 212.5725450093154 1688629.9194347535 0.02900995765526861 0.07028638873737816 5.517036627650472e-06 5.258294132748136 0.283289515072785 TGS(ph)PGDAPERPPLCDFSEGLSAPMDFYR ddPTM_A459_Selumetinib_30min_R1 1 TGSPGDAPERPPLCDFSEGLSAPMDFYR 28 1 Q8IWE5;Q5VVD7;A0A2R8Y575 Q8IWE5 PLEKHM2 Pleckstrin homology domain-containing family M member 2 1 T(0.223)GS(0.732)PGDAPERPPLCDFS(0.018)EGLS(0.027)APMDFYR 53.563 0.0060707 8373100.0 644.19 930.64 1094.2 982.37 509.93 888.86 783.9 819.43 535.24 717.26 True False 659.198373624462 821.6802361572015 945.6136500103714 810.8175208687634 463.8069215354536 879.9188754203076 724.7697918784895 797.6960545162354 908.2631876171037 809.3273077040436 0.8145015834131707 1.0152632048067198 1.1683945926561585 1.0018412985086926 0.5730770692159314 1.0872225205356323 0.8955212371797601 0.9856284928519161 1.1222445838306485 1.0 9.660579464375726 TGS(ph)PGPELLFHEGQQK ddPTM_A459_Selumetinib_30min_R1 2 TGSPGPELLFHEGQQK 16 0 A6NHN7;A6NHB5;Q14202-2;Q14202;A6NL54;Q14202-3 A6NHN7 ZMYM3 Zinc finger MYM-type protein 3 1 T(0.023)GS(0.977)PGPELLFHEGQQK;T(0.101)GS(0.899)PGPELLFHEGQQK 189.84 6.493800000000001e-07 20438600.0 14012.4 15576.5 15081.7 16436.2 12363.1 13434.099999999999 13121.599999999999 14046.9 8725.9 14460.2 True False 14338.861656615907 13752.796138681602 13033.687977848122 13565.926215685708 11244.859787882591 13298.965151186856 12131.827147739228 13674.330581238311 14807.214985479575 16316.307524275715 0.8788055529893803 0.8428865488236189 0.7988135770581887 0.8314335946109169 0.689179201308401 0.8150719843567793 0.7435399908765671 0.8380775221902003 0.9075101681829125 1.0 13.994026983479609 -8.43415402670386 2.0027229885622093 0.9974689499361648 0.7989818841570925 0.6135764712962553 0.050432168996918214 0.20958534109709523 1.7960240210262342 0.04956714332345606 0.013991805881369163 3.67998436320376e-09 8.43415402670386 -0.19848706577907227 TGS(ph)PGPELLFHEGQQK ddPTM_A459_Selumetinib_30min_R2 2 TGSPGPELLFHEGQQK 16 0 A6NHN7;A6NHB5;Q14202-2;Q14202;A6NL54;Q14202-3 A6NHN7 ZMYM3 Zinc finger MYM-type protein 3 1 T(0.139)GS(0.861)PGPELLFHEGQQK;T(0.259)GS(0.741)PGPELLFHEGQQK 96.455 0.0053909 39230000.0 159450.0 137413.0 147568.0 147917.0 139505.0 109064.0 127982.0 130101.0 88866.0 144495.0 True False 150588.4073289233 147952.1352475649 138073.63553989033 127770.44942894243 121979.13470947636 124086.57601558206 133933.41659152193 130479.57237061986 106641.6831235005 140323.05390690305 1.0731551454747468 1.0543679825107237 0.9839697162769484 0.9105449594455904 0.86927366040938 0.884292156995863 0.9544648071896988 0.9298512877091898 0.7599726499271576 1.0 17.098392525624575 -5.505000429702526 1.971267703032486 0.8970576119959358 1.0705354372090439 0.5533344605529467 0.059025096122415605 0.252469409940643 1.9061643035970097 0.01698454402786427 0.04574657291880646 3.12607627409931e-06 5.505000429702526 0.17347782521310806 TGS(ph)PTFVR ddPTM_A459_Selumetinib_30min_R2 1 TGSPTFVR 8 0 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;Q9UPP1-5;B0QZZ4;Q5JPR8;B0QZZ2;B0QZZ3;B0QZE1 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 T(0.031)GS(0.939)PT(0.031)FVR 91.087 0.027357 3416400.0 22012.0 21792.0 25223.0 24285.0 21782.0 16326.0 16708.0 22739.0 18561.0 19524.0 True False 20788.66116101763 23463.376327675953 23600.179640725968 20977.341106038322 19045.550426449317 18574.75830732774 17484.955106273923 22805.166725355906 22273.718637671223 18960.29139055592 1.0964315227440236 1.237500829726858 1.244716083450129 1.1063828436986516 1.0044967154848614 0.9796662891256926 0.9221881007052001 1.2027856669288906 1.1747561352757327 1.0 14.210693515962816 -5.960454910298381 5.16001022377284 1.048159710008721 1.1961268043919382 0.3494552102151016 0.08878709899878418 0.22883823699229203 14.740748445901525 0.027809378004205895 0.041180832170408306 1.0953302698010153e-06 5.960454910298381 0.1479670943832172 TGS(ph)QGQCTQVR ddPTM_A459_Selumetinib_30min_R1 2 TGSQGQCTQVR 11 0 P62857 P62857 RPS28 40S ribosomal protein S28 1 T(0.229)GS(0.771)QGQCTQVR;T(0.207)GS(0.793)QGQCT(0.001)QVR 163.33 0.0006369 8601900.0 1030.75 1868.24 1766.52 2518.1000000000004 1413.22 1532.8899999999999 1512.55 1635.75 708.98 1128.6799999999998 True False 1054.7644695096387 1649.505592278788 1526.636286799782 2078.361105591205 1285.3945005242556 1517.4705183527603 1398.4571357390084 1592.364596335175 1203.087278149567 1273.5570722742086 0.8282035351789387 1.2951956596128378 1.1987183927875698 1.631934014452801 1.0092947764240425 1.1915214099066578 1.0980718227584132 1.2503284155861718 0.9446669523818021 1.0 10.314647897624827 -8.265354140226602 24.538913400226797 0.972333439902922 1.1978180065510449 0.16065419747296195 0.1960543215011954 482.54165561617583 3024634.21234479 0.1638215663681623 0.04857685113329168 5.428075250901558e-09 8.265354140226602 0.22548456664812289 TGS(ph)SGALGPPER ddPTM_A459_Selumetinib_30min_R2 1 TGSSGALGPPER 12 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 T(0.152)GS(0.695)S(0.152)GALGPPER 99.941 0.013904 13648000.0 34370.0 29715.0 31215.0 23519.0 32793.0 22797.0 22882.0 23248.0 20626.0 23896.0 True False 32459.852994011264 31994.044951215623 29206.660884322268 20315.671627462034 28673.250166860355 25937.07981943835 23946.058339822812 23315.64783108642 24751.77633859202 23206.060390735744 1.3987662036322974 1.3786935142161483 1.2585790260195162 0.8754468136940813 1.2355931891958365 1.117685612409803 1.0318881333852983 1.0047223629735285 1.0666082877416518 1.0 14.502214001879924 -5.556605205799927 6.550628793046585 1.057472073108838 1.3728264452635972 0.7204393176596435 0.08728003035650174 0.09047448186874293 11.650871048177711 0.02390685811713203 0.04245986792135768 2.775842329875553e-06 5.556605205799927 0.31535437215475914 TGS(ph)SSPPGGPPKPGSQLDSMLGSLQSDLNK ddPTM_A459_Selumetinib_30min_R1 1 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNK 30 1 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;P49023-4 A0A1B0GTU4 PXN Paxillin 1 T(0.208)GS(0.226)S(0.226)S(0.226)PPGGPPKPGS(0.056)QLDS(0.034)MLGS(0.02)LQS(0.003)DLNK 54.011 0.011273 40797000.0 3180.9 3475.9 4290.6 4293.9 3167.0 3725.8 3060.4 3093.1 1972.6 2722.9 True False 3255.008781046043 3068.940012097928 3707.960086578776 3544.0509714856726 2880.5454091792635 3688.321834755733 2829.551564057823 3011.06094019522 3347.358126996299 3072.410738292028 1.059431520817924 0.9988703573546195 1.2068568959110115 1.1535081971025243 0.937552187693686 1.200465090421502 0.9209548478634689 0.9800320323932625 1.0894891380496592 1.0 11.585155381738762 -7.275590013225718 24.981790357545 0.9959550168045255 1.0894018415891253 0.21941506952201806 0.0877703933644731 1334.8806139725823 2356612.404116232 0.036715990188268946 0.024887384710434432 5.301636978633076e-08 7.275590013225718 0.09344682478459987 TGS(ph)TSSKEDDYESDAATIVQK ddPTM_A459_Selumetinib_30min_R2 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 T(0.143)GS(0.523)T(0.111)S(0.111)S(0.111)KEDDYESDAATIVQK 86.179 0.00057643 23926000.0 108940.0 76176.0 79869.0 85917.0 67391.0 66322.0 68189.0 84676.0 45151.0 88145.0 True False 102885.55092137291 82018.45425555424 74730.31549479208 74214.95638490815 58924.74009681601 75457.253488827 71359.92361394022 84922.39314113362 54182.4616243464 85600.02482178606 1.2019336575611308 0.9581592344898447 0.8730174512259309 0.8669969026226227 0.6883729323618031 0.8815097150488486 0.8336437257174534 0.9920837443439622 0.6329724989817576 1.0 16.38532359452006 -4.59182561106624 1.4359589991061679 0.838118567240684 1.492119568045288 0.5007840640543691 0.10835141138292514 1.4909706103421387 2.0121531089038793 0.029283989978356188 1.5959798422669418 2.559613481493908e-05 4.59182561106624 0.6540010008046039 TGS(ph)YGALAEITASK ddPTM_A459_Selumetinib_30min_R1 3 TGSYGALAEITASK 14 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 T(0.233)GS(0.767)YGALAEITASK;T(0.039)GS(0.959)YGALAEIT(0.001)ASK;T(0.064)GS(0.936)YGALAEITASK 196.18 0.00011976 435973000.0 12768.3 13679.4 15399.6 14244.099999999999 10476.699999999999 11656.3 11667.400000000001 11820.599999999999 7640.599999999999 10662.0 True False 13065.776547213109 12077.809488619465 13308.418903947828 11756.635329872399 9529.08433481162 11539.048205073612 10787.318624522368 11507.079289279889 12965.540152655347 12030.571556674719 1.086047864447807 1.0039264910833383 1.1062166781730451 0.9772299906524111 0.7920724539080406 0.9591438071511738 0.8966588639371355 0.9564865006680094 1.0777160579259342 1.0 13.554417564240703 -5.950061715444271 7.251297337990801 0.93776529474543 1.0573444109922134 0.3394575698161538 0.07298715906474472 0.24551983896185153 29.050104413809258 0.020927249559100383 0.03108490826752167 1.121859021128365e-06 5.950061715444271 0.11957911624678341 TGS(ph)YGALAEITASK ddPTM_A459_Selumetinib_30min_R2 3 TGSYGALAEITASK 14 0 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4;H0YHI8 O14974-5;H0YHI8 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 T(0.065)GS(0.905)Y(0.019)GALAEIT(0.01)AS(0.001)K;T(0.01)GS(0.99)YGALAEITASK;T(0.032)GS(0.968)YGALAEITASK 111.43 0.0039332 80795400.0 71499.2 61225.0 64909.6 60053.0 56723.1 50029.5 60705.3 57095.3 42935.2 55081.0 True False 67525.56069797522 65920.7606305965 60733.38700422894 51873.67780279675 49597.03706705205 56920.609502416584 63528.216735269896 57261.437870364236 51523.439709721504 53490.66841237509 1.2623802001762452 1.2323787043077163 1.1354015346381099 0.9697706037787285 0.9272091476721527 1.0641222327528062 1.1876504560667 1.0704939678248024 0.9632229553108657 1.0 15.706999611074115 -5.446988812006685 3.059482839788946 1.0335867908821117 1.2483168316509645 0.615363784816439 0.06989156303230801 0.19394958842143872 3.494509812731351 0.021606725670005766 0.05002684724739893 3.572820420856143e-06 5.446988812006685 0.21473004076885283 TGSCS(ph)ELDACPSK ddPTM_A459_Selumetinib_30min_R1 1 TGSCSELDACPSK 13 0 A0A1B0GUA8;Q9H1H9-3;Q9H1H9-4;Q9H1H9-2;Q9H1H9;H0Y9Z7 A0A1B0GUA8 KIF13A Kinesin-like protein KIF13A 1 T(0.077)GS(0.258)CS(0.665)ELDACPSK 147.7 0.00056637 18282000.0 3622.1 3705.2 5130.2 5256.6 3489.6 3958.1 4219.0 4314.1 2499.0 4037.8 True False 3706.487882620285 3271.39346149925 4433.547018171454 4338.63348860281 3173.96629613892 3918.2851076672555 3900.7574332636127 4199.676053828264 4240.62048026146 4556.090961502642 0.8135236793862979 0.7180263715411672 0.973103271122846 0.9522710422734596 0.6966424338227251 0.8600102896924973 0.8561632035496293 0.9217717752595465 0.9307585199885613 1.0 12.1535808351319 -8.119753790986472 1.141476927025283 0.992014520818308 0.8354575064373314 0.3024220476223476 0.08236504152513173 0.6399345763686075 1.5736501913084247 0.08032385569060159 0.02732486074627536 7.59007747631875e-09 8.119753790986472 -0.15655701438097658 TGSDHTNPT(ph)SPLLVKPSDLLEENK ddPTM_A459_Selumetinib_30min_R2 2 TGSDHTNPTSPLLVKPSDLLEENK 24 1 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;Q96D71;Q96D71-3;H0YE73 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 1 T(0.001)GS(0.001)DHT(0.001)NPT(0.499)S(0.499)PLLVKPSDLLEENK;TGSDHTNPT(0.5)S(0.5)PLLVKPSDLLEENK 69.779 0.00093598 8900800.0 29570.9 22322.2 30996.0 44296.0 46329.0 29687.6 34249.0 45400.0 39871.0 51271.0 True False 27927.467759691823 24034.240962814245 29001.751105893094 38262.80838513786 40508.73683348499 33776.797422799405 35841.64636310603 45532.106483625386 47846.31408882008 49790.6730119439 0.5608975751943043 0.48270568580281803 0.5824735708821628 0.7684734121982905 0.8135808251430475 0.6783759965384872 0.7198465936483376 0.9144705971880123 0.9609493343731786 1.0 15.603587895745374 -5.340632391256551 0.21564508856121112 1.0559437627274415 0.13842898258027758 0.8072598370536329 0.07342449050238745 4.614172854565068 0.24504256458210943 0.1681584741309736 1.1449608544747072 4.564230920034008e-06 5.340632391256551 -0.9175147801471639 TGSEPALS(ph)PAVVR ddPTM_A459_Selumetinib_30min_R1 2 TGSEPALSPAVVR 13 0 O75815;O75815-3;O75815-2 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 TGSEPALS(1)PAVVR;TGSEPALS(1)PAVVR 135.04 0.0011682 47541000.0 3467.2 3920.5 3929.7000000000003 4669.1 4404.0 3645.2 4049.6000000000004 3828.1000000000004 2134.75 3182.3999999999996 True False 3547.979014003216 3461.486037408998 3396.068324296978 3853.729334861959 4005.6589775893526 3608.5325975767873 3744.1354116483335 3726.566352578746 3622.5148340288697 3590.8920392010546 0.988049480538717 0.9639627144510732 0.9457450369498095 1.073195543834669 1.115505265505164 1.0049125838881132 1.0426755721905174 1.0377828995961342 1.0088063897445525 1.0 11.810126563437251 -5.757192663735662 24.999979279910928 1.0437296301749197 0.9657234309347021 0.49956878112670733 0.03405265036998396 88.89742670188654 523320.7629500614 0.009729118926756593 0.0161214593356691 1.7490705856693219e-06 5.757192663735662 -0.07800619924021757 TGSEPALS(ph)PAVVR ddPTM_A459_Selumetinib_30min_R2 4 TGSEPALSPAVVR 13 0 O75815;O75815-3;O75815-2 O75815 BCAR3 Breast cancer anti-estrogen resistance protein 3 1 TGSEPALS(1)PAVVR;T(0.003)GSEPALS(0.997)PAVVR;TGSEPALS(1)PAVVR;TGSEPALS(1)PAVVR 181.67 0.00011565 125490200.0 133386.0 123235.0 131853.0 145101.0 154713.0 105857.0 130609.0 132641.0 94560.0 117771.0 True False 125972.94010646462 132686.72823702052 123369.7215306921 125337.9934868134 135276.56978823114 120437.8408758294 136682.57729682364 133026.96335010027 113474.64222715296 114370.64522419365 1.1014446920320133 1.1601467140184702 1.0786834444175613 1.0958930348003295 1.182790999587848 1.0530485391574262 1.1950844294783272 1.1631215605135024 0.9921657957312009 1.0 16.803357286834 -8.269726340687916 24.709920849603154 0.9960828616469639 1.1285429137488043 0.5899444611369704 0.04425098480829455 391.8593799358422 1168423.2493305157 0.03912637714877864 0.010816627128469218 5.373702995529957e-09 8.269726340687916 0.13246005210184042 TGSES(ph)PKVCSDQSSGSGTGK ddPTM_A459_Selumetinib_30min_R1 2 TGSESPKVCSDQSSGSGTGK 20 1 O15169-2;O15169 O15169-2 AXIN1 Axin-1 1 T(0.012)GS(0.041)ES(0.535)PKVCS(0.413)DQSSGSGTGK;T(0.059)GS(0.059)ES(0.882)PKVCSDQSSGSGTGK 106.99 0.00025232 25921000.0 5558.9 5500.1 10189.900000000001 10558.5 5758.4 7027.1 5111.3 5723.6 4306.2 4913.2 True False 5688.4115542635245 4856.14573507288 8806.167549114127 8714.656182591933 5237.553736728095 6956.413754096301 4725.7505258687615 5571.79153512701 7307.306887595792 5543.857078620734 1.0260747118103475 0.8759507444374899 1.5884550096130958 1.5719482048336044 0.9447490551165427 1.254796733653711 0.8524300787069513 1.0050388125289165 1.318090777587973 1.0 12.436674349744914 -6.335925919676911 24.99999795373895 1.061879176065447 1.2608606925767814 0.14677699001677658 0.23976747233006604 296.3162972060029 99451.26128062267 0.07982416634864824 0.09051210477610067 4.6139627109290185e-07 6.335925919676911 0.19898151651133444 TGSES(ph)PKVCSDQSSGSGTGK ddPTM_A459_Selumetinib_30min_R2 2 TGSESPKVCSDQSSGSGTGK 20 1 O15169-2;O15169 O15169-2 AXIN1 Axin-1 1 T(0.049)GS(0.049)ES(0.901)PKVCSDQSSGSGTGK;T(0.018)GS(0.055)ES(0.914)PKVCS(0.014)DQSSGSGTGK 126.43 0.00011740000000000002 11766200.0 44489.0 53544.0 44624.0 45399.0 39546.0 25409.0 24040.0 23974.0 14264.5 44498.0 True False 42016.47948357775 57650.652628904216 41752.9404229376 39215.57788235674 34577.87793427437 28908.85911006311 25157.907634356296 24043.760370890654 17117.798583430907 43213.227120311305 0.9723059878540973 1.3340973695021021 0.9662074139173158 0.907490148170962 0.800168842701912 0.6689817224151542 0.5821807189801719 0.5563981672544304 0.3961240509942177 1.0 15.399185353513934 -6.1464797046473025 1.0538268521101175 0.5981216437573327 1.153099707106469 0.5710354377209225 0.1705162235533429 0.34028549474179554 0.7828112852567195 0.06971867729906114 0.12134629488074211 7.137075571652717e-07 6.1464797046473025 0.5549780633491364 TGSES(ph)SQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R1 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 T(0.015)GS(0.142)ES(0.695)S(0.142)QT(0.002)GT(0.003)STTSSR 185.02 7.9267e-07 6779800.0 222.27 224.27 223.89 256.26 156.83 52.29 130.56 276.79 159.58 116.81 True False 227.44845853786782 198.01236413970565 193.48696773973856 211.50900159596605 142.6447541905854 51.764010075521284 120.71175408554095 269.4486300593694 270.7956047379445 131.80370132575254 1.725660632061686 1.5023277961695367 1.4679934310914073 1.6047273291151516 1.0822515055024078 0.392735633027381 0.9158449487484583 2.044317628026452 2.054537179260799 1.0 7.042247074607257 -6.247289853191803 23.304663773274125 1.2410979448501018 1.5623178201840988 0.10170250662728686 0.4750462294360142 968.0804764267828 1594450.7183896767 0.16021503141736945 0.20557107302411146 5.658615004307957e-07 6.247289853191803 0.321219875333997 TGSES(ph)SQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 2 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 T(0.266)GS(0.136)ES(0.597)SQTGTSTTSSR;TGS(0.073)ES(0.544)S(0.359)QT(0.022)GTSTTSSR 176.08 1.2276e-06 43534400.0 3835.9 3207.5499999999997 2595.99 3272.3199999999997 1977.47 1931.26 1801.7400000000002 2183.2 2180.62 3172.3 True False 3622.7160343243477 3453.558771101181 2428.966829700201 2826.62437093314 1729.042539793899 2197.273534767227 1885.524480080079 2189.5527505517825 2616.804931613524 3080.707456374749 1.1759363995526573 1.1210278223448025 0.7884444933822148 0.9175244358513016 0.561248532773237 0.7132366723820277 0.6120426904471116 0.7107304999119777 0.8494168851374395 1.0 11.589045975388677 -5.24057089719048 1.4365795838124864 0.7294284076469604 1.2336792730076278 0.5763761154221867 0.12826924327547787 0.3836618248624665 1.2314815502083618 0.03756219225846965 0.2170891020222133 5.746839958562348e-06 5.24057089719048 0.5042508653606674 TGSESSQTGT(ph)STTSSR ddPTM_A459_Selumetinib_30min_R2 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 TGS(0.002)ES(0.005)S(0.02)QT(0.361)GT(0.581)S(0.011)T(0.011)T(0.007)S(0.001)SR 97.823 0.017343 1029400.0 1292.6 1211.9 3096.7 2996.4 2497.1 912.85 962.9 666.39 2299.3 3105.4 True False 1220.7624666877791 1304.8488331273154 2897.461693432029 2588.2851509216903 2183.3919736427597 1038.5868014727512 1007.6767579501532 668.3290845731967 2759.224247809788 3015.7390332018217 0.40479711714036837 0.4326796247160526 0.960779981799613 0.8582589947027671 0.7239989765708089 0.34438881814321964 0.3341392431029746 0.22161369973171358 0.9149413186724943 1.0 11.558295875140313 -8.445676824913612 8.247269046858962 0.9997020407703155 0.5501835174369086 0.3532933761042857 0.22928224832131552 0.3619203979524209 34.081364906710334 0.24936375211530099 0.06444806219766928 3.5836300948901153e-09 8.445676824913612 -0.4495185233334069 TGSESSQTGTSTTS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 T(0.01)GSESSQTGT(0.001)S(0.004)T(0.012)T(0.056)S(0.905)S(0.012)R 83.25200000000002 0.044564 0.0 0.0 0.0 0.0 0.0 603.61 0.0 743.87 516.64 0.0 554.74 True False 0.0 0.0 0.0 0.0 527.7791154581337 0.0 778.4614289504416 518.143336865644 0.0 538.7232148123846 0.0 0.0 0.0 0.0 0.9796851164877638 0.0 1.4450118493994137 0.9617987913256943 0.0 1.0 9.073400425311991 -6.248282678967737 23.76036985385565 0.7283148838511841 1.3619858924167905e-07 0.4207311610193105 0.4202444908839778 408.0459003144274 736909.7604930933 0.1231435070524951 0.15785066927435518 5.645693812866808e-07 6.248282678967737 -0.7283147476525949 TGSESSQTGTSTTSSR ddPTM_A459_Selumetinib_30min_R2 3 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 ;; 232.37 2.5552000000000002e-14 2269910.0 0.0 542.02 1202.0 640.19 898.97 0.0 455.37 419.76 0.0 678.89 False True 0.0 583.5911911310075 1124.6646286386479 552.9950176106515 786.0333517062323 0.0 476.5456072985367 420.9814321049911 0.0 659.2886817319459 0.0 0.8851830879273072 1.7058758322441745 0.8387752329646222 1.1922445712875418 0.0 0.7228178194211606 0.638538843104475 0.0 1.0 9.364766504033993 -6.7436061526828475 24.978937798138027 0.4653390022237029 0.9608927840192105 0.1755597723887834 0.48659228884588757 411.64806962014677 576592.9102231484 0.16184029563333036 0.16151071869151065 1.8046535797115506e-07 6.7436061526828475 0.49555378179550763 TGSGQGPSS(ph)TGQPGR ddPTM_A459_Selumetinib_30min_R2 2 TGSGQGPSSTGQPGR 15 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 TGSGQGPS(0.075)S(0.922)T(0.004)GQPGR;TGSGQGPS(0.19)S(0.62)T(0.19)GQPGR 176.17 1.9223e-05 2502100.0 9451.5 7661.1 7431.5 8410.5 8540.7 5244.4 6137.4 6986.6 3785.3 5305.7 True False 8926.223467352263 8248.6817356809 6953.365380805417 7264.975391078249 7467.740911173248 5966.768496076783 6422.801261027382 7006.929849306107 4542.465770118898 5152.51065513586 1.7324027187512723 1.6009053232056638 1.349510141017277 1.4099874560835213 1.4493402170317957 1.1580312774568056 1.2465381812700058 1.3599059406741487 0.8816024020428005 1.0 12.33105986785132 -1.5228787453169077 0.16732711983959445 0.9214622446665481 4.112337254980134 0.7587633163904027 0.12055744160876587 30.004926071662847 0.321090406010686 0.321490927157238 23.86112996052206 0.029999999997473825 1.5228787453169077 3.1908750103135857 TGSGS(ph)PFAGNS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 2 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 2 T(0.002)GS(0.1)GS(0.898)PFAGNS(1)PAR;T(0.017)GS(0.208)GS(0.775)PFAGNS(1)PAR 187.56 0.001575 58830000.0 10403.7 14625.5 9108.7 9991.599999999999 10660.099999999999 9245.2 12926.8 11595.2 5816.200000000001 11106.3 True False 10646.085967923762 12913.139660789511 7871.788570507642 8246.754625560967 9695.895837193513 9152.201681969966 11951.721068573615 11287.657629482273 9869.666601559304 12531.901789523214 0.8495187838787557 1.0304213899589458 0.628139982479637 0.658060904407608 0.7736970812601941 0.7303122730838261 0.9537036971168547 0.9007138596409094 0.7875633536970771 1.0 13.613317748248885 -7.260190589002661 24.994442320659736 0.9022213835681138 0.7773077539273943 0.2379090646285792 0.11547000605783904 198.11663298338368 3965340.003473617 0.049315693040115016 0.0360484234304369 5.49299762185393e-08 7.260190589002661 -0.1249136296407195 TGSGS(ph)PFAGNS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 2 T(0.001)GS(0.011)GS(0.988)PFAGNS(1)PAR;TGS(0.022)GS(0.978)PFAGNS(1)PAR 170.48 0.0028853000000000004 124211000.0 265950.0 231030.0 240860.0 270890.0 281440.0 212961.0 247030.0 248550.0 198189.0 233390.0 True False 251169.56368220257 248749.25812146504 225363.32982853966 233994.31468868567 246082.99109447675 242294.44468252014 258517.384480659 249273.23935033224 237832.3378633382 226651.42427995562 1.1081755364217902 1.0974969996844783 0.9943168481931756 1.032397283326401 1.0857332658563823 1.0690179664754391 1.140594572930383 1.0998088370379466 1.0493308772221617 1.0 17.790115701600143 -6.3000404067586215 24.097218035914928 1.0821439041648795 1.0563552568456145 0.01016832003975332 0.0453197020114087 1116.3016907198432 696861.6081043525 0.014556729378470338 0.016505895059057682 5.011406053362082e-07 6.3000404067586215 -0.025788647319265 TGSGS(ph)PFAGNS(ph)PAREGEQDAASLK ddPTM_A459_Selumetinib_30min_R1 2 TGSGSPFAGNSPAREGEQDAASLK 24 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 2 T(0.015)GS(0.059)GS(0.925)PFAGNS(0.868)PAREGEQDAAS(0.134)LK;T(0.058)GS(0.072)GS(0.876)PFAGNS(0.991)PAREGEQDAAS(0.003)LK 61.03 0.014563 28915000.0 6161.9 6755.5 7871.4 8157.5 6172.700000000001 6133.4 6166.1 6508.8 3547.5 5255.700000000001 True False 6305.460281029771 5964.56291945325 6802.507114505241 6732.945760239963 5614.3803748787 6071.703564681626 5700.986112644408 6336.1654804379605 6019.848400851351 5930.320289853251 1.06325796463614 1.005774161921505 1.1470724652333362 1.1353426849069181 0.9467246456291539 1.0238407485461252 0.9613285343792928 1.0684356275459705 1.0150966738088805 1.0 12.533894309855707 -6.25750722808103 24.99973030034755 1.0049941803276055 1.0862277455032492 0.4316892081897967 0.04787879711041201 379.8582603572651 2415047.710224763 0.015053524712841073 0.01870927754484023 5.527042090616025e-07 6.25750722808103 0.08123356517564373 TGSGS(ph)PFAGNSPAR ddPTM_A459_Selumetinib_30min_R1 2 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 T(0.006)GS(0.206)GS(0.788)PFAGNSPAR;T(0.064)GS(0.009)GS(0.926)PFAGNSPAR 199.84 7.722e-05 139676000.0 4090.8 5128.0 5164.8 5290.3 4226.3 3874.5 4589.0 4181.7 2214.3 3474.7 True False 4186.107680688844 4527.611376057479 4463.448528215648 4366.448416230154 3844.031911213869 3835.526047764529 4242.848035374906 4070.787731924073 3757.505373926748 3920.7115914441592 1.0676907961870585 1.1547932742458553 1.1384281715482105 1.1136877361136914 0.980442407343192 0.9782729380387163 1.082162749393176 1.0382777812087511 0.958373317263743 1.0 11.936899805400403 -6.2160776520200605 7.579701248599025 1.0106063648914312 1.1230746803326535 0.6666247254121549 0.038820772751739695 0.17952377042654505 26.669873417410123 0.01194417906598872 0.01536607654706697 6.080262762273976e-07 6.2160776520200605 0.11246831544122227 TGSGS(ph)PFAGNSPAR ddPTM_A459_Selumetinib_30min_R2 4 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 T(0.355)GS(0.037)GS(0.608)PFAGNSPAR;T(0.006)GS(0.378)GS(0.614)PFAGNS(0.002)PAR;T(0.03)GS(0.022)GS(0.942)PFAGNS(0.006)PAR;T(0.004)GS(0.003)GS(0.993)PFAGNSPAR 180.56 7.3881e-05 165897000.0 145505.0 131455.0 148102.0 150878.0 159427.0 125298.0 118613.0 129328.0 104134.0 130202.0 True False 137418.4146026653 141537.17580555406 138573.27856126524 130328.15612093266 139398.35496453661 142556.6621580025 124128.7395272007 129704.32306859703 124963.70974706383 126442.72995457739 1.0868036039085105 1.1193777282125996 1.0959370982502954 1.0307287431056815 1.1024623955415493 1.127440559130713 0.981699300321909 1.025795022894486 0.9883028450267969 1.0 16.948124563553435 -7.267368829290188 24.997522994995393 1.0010988738206106 1.0925798345184559 0.7535259046692244 0.026556444967212916 263.42534242169376 1110549.7824350605 0.011406669148392262 0.007927127989375423 5.402952764356118e-08 7.267368829290188 0.09148096069784528 TGSGSPFAGNS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 4 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 TGSGSPFAGNS(1)PAR;TGSGSPFAGNS(1)PAR;TGSGSPFAGNS(1)PAR;TGSGSPFAGNS(1)PAR 201.4 5.9034e-05 253065000.0 11481.400000000001 13476.499999999998 11526.400000000001 12071.9 12187.2 11305.1 13070.8 12660.7 6696.699999999999 10153.199999999999 True False 11748.894281084613 11898.665114945117 9961.178189983126 9963.76928262836 11084.869911824924 11191.38095820952 12084.85903263854 12324.897108250498 11363.810792383714 11456.462120543029 1.0255255206594025 1.0385985647008038 0.8694811788467706 0.8697073475031997 0.9675648376603291 0.9768618654219455 1.0548508697958952 1.0758030689203995 0.991912745210131 1.0 13.483873972582796 -7.0646646975520815 3.234069881301548 1.0365970877461828 0.9502119472615506 0.2847260887885765 0.05665705968037477 0.3407406991346122 6.996727256194328 0.025283595134211606 0.01969684091411427 8.61658749779779e-08 7.0646646975520815 -0.0863851404846322 TGSGSPFAGNS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 3 TGSGSPFAGNSPAR 14 0 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 TGSGSPFAGNS(1)PAR;TGSGSPFAGNS(1)PAR;TGSGSPFAGNS(1)PAR 140.68 0.00056051 157473000.0 100705.0 91644.0 106522.0 125936.0 126280.0 91932.0 96907.0 101406.0 91688.0 113050.0 True False 95108.21925405588 98672.80011809514 99668.49049238446 108783.29954828235 110415.5774424762 104594.79852439395 101413.36751757756 101701.07467133304 110028.16197676853 109785.95276082512 0.8663059058316366 0.8987743662712423 0.9078437449053056 0.9908671994246193 1.0057350204267277 0.9527156789563015 0.9237371901167747 0.9263578091169329 1.002206194962584 1.0 16.744333946095388 -5.613115248836542 4.561777022341323 0.9670486655595533 0.8868212937485285 0.6127126889366362 0.02958441546135147 0.15836072230500126 5.826747019061837 0.008856227667532171 0.015934292094827007 2.437163981724497e-06 5.613115248836542 -0.0802273718110248 TGSGSPFAGNS(ph)PAREGEQDAASLK ddPTM_A459_Selumetinib_30min_R1 1 TGSGSPFAGNSPAREGEQDAASLK 24 1 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 T(0.002)GS(0.005)GS(0.01)PFAGNS(0.956)PAREGEQDAAS(0.027)LK 47.288 0.032259 22178000.0 1947.1 1724.8 2620.7 2723.8 2192.2 1923.3 2194.8 2055.9 934.25 1421.7 True False 1992.4636416029257 1522.859614162235 2264.8233344746645 2248.139462058427 1993.9158970643452 1903.9533482166792 2029.244468956382 2001.3708534956365 1585.3540150797392 1604.1890435307116 1.2420379316502799 0.9493018421385823 1.4118182290348658 1.4014180380576744 1.2429432211280231 1.186863453465688 1.264965919783464 1.2475904018710628 0.9882588473428806 1.0 10.647628448957263 -8.261222099870993 24.865080322906994 0.9941293938539882 1.2432709314537347 0.4090688146649951 0.11982412730903724 18.502720461866474 2118163.4314540676 0.09855923093939327 0.031856975691800606 5.479966456532588e-09 8.261222099870993 0.24914153759974644 TGSGSPFAGNS(ph)PAREGEQDAASLKDVFK ddPTM_A459_Selumetinib_30min_R1 1 TGSGSPFAGNSPAREGEQDAASLKDVFK 28 2 Q9UPT8;M0QY97 Q9UPT8 ZC3H4 Zinc finger CCCH domain-containing protein 4 1 TGSGS(0.001)PFAGNS(0.993)PAREGEQDAAS(0.006)LKDVFK 75.43 0.00011463 10545000.0 399.32 256.38 1109.4 1052.0 442.88 576.62 451.02 471.28 202.5 346.1 True False 408.6233790585385 226.36291041217157 958.7495734979948 868.2879484857422 402.8215821968148 570.8197263290705 416.9991982817146 458.78012346681425 343.627709985172 390.5253062994862 1.0463428937052628 0.579636983214036 2.455025469624108 2.2233845911636494 1.0314865021523056 1.461671541181303 1.0677904646771497 1.174776937797175 0.8799115049452151 1.0 8.609272228768955 -7.171058655097952 1.4288285676210464 1.0086759971011436 1.5226813134840582 0.14416198922222467 0.5236234839646075 0.9471124357341661 3.818091069597561 0.3277057190914864 0.20847575307079913 6.744369332043322e-08 7.171058655097952 0.5140053163829146 TGSNIS(ph)GASSDISLDEQYK ddPTM_A459_Selumetinib_30min_R1 3 TGSNISGASSDISLDEQYK 19 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 T(0.003)GS(0.003)NIS(0.967)GAS(0.027)SDISLDEQYK;T(0.003)GS(0.009)NIS(0.849)GAS(0.128)S(0.003)DIS(0.008)LDEQYK;TGSNIS(0.974)GAS(0.008)S(0.018)DISLDEQYK 284.07 5.199699999999998e-72 19956100.0 5089.99 6047.700000000001 4637.69 5083.68 4692.099999999999 4573.889999999999 4824.05 3880.9199999999996 2399.49 4340.65 True False 5208.576863603552 5339.632472500551 4007.9171710076757 4195.910720492392 4267.700383457535 4527.88081935984 4460.168024635066 3777.985394595206 4071.759278184298 4897.814709011455 1.0634491447829433 1.0902071208770308 0.8183072266154815 0.8566903751528953 0.8713478636922346 0.9244696029494589 0.910644499561985 0.7713614375088785 0.8313420413174668 1.0 12.257922480481753 -5.255456799010726 24.997087108204326 0.8673929602462122 1.0768281589680635 0.6469350285419433 0.06011021954255518 277.65049137396545 1160101.985329282 0.015394128274404742 0.03855489957879077 5.553198542337738e-06 5.255456799010726 0.20943519872185135 TGSNIS(ph)GASSDISLDEQYK ddPTM_A459_Selumetinib_30min_R2 2 TGSNISGASSDISLDEQYK 19 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 T(0.011)GS(0.011)NIS(0.979)GASSDISLDEQYK;T(0.001)GS(0.001)NIS(0.931)GAS(0.061)S(0.006)DISLDEQYK 151.64 2.0753000000000006e-05 19271600.0 155682.0 129220.0 144210.0 148108.0 157523.0 114677.0 135336.0 146317.0 111935.0 126077.0 True False 147029.81768442414 139130.7584922121 134931.68560397625 127935.434899449 137733.5524665124 130472.71581584106 141629.39216319632 146742.75824591672 134325.12772521537 122436.82942261401 1.2008626683473054 1.1363472833160013 1.1020514516774513 1.0449097342912688 1.1249356351028892 1.065632918061686 1.1567548165947317 1.1985181169581431 1.097097404095353 1.0 16.90167806541814 -12.038256680608153 1.612007137164825 0.16121506703263522 1.123837848856033 0.37438327271301375 0.048536871438639696 801995.4281576107 52520.53710545026 2444747.840927267 0.013216814081706364 9.156791372884438e-13 12.038256680608153 0.9626227818233978 TGSNISGAS(ph)SDISLDEQYK ddPTM_A459_Selumetinib_30min_R2 1 TGSNISGASSDISLDEQYK 19 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 T(0.003)GSNIS(0.006)GAS(0.916)S(0.075)DISLDEQYK 108.13 0.0019463 0.0 9144.1 10198.0 14065.0 9870.0 14145.0 14637.0 7927.5 9750.5 14085.0 12824.0 True False 8635.907528732567 10980.153808261708 13160.073212814117 8525.688973300312 12367.978642095568 16653.113888543183 8296.144458043244 9778.872340717835 16902.393567781874 12453.737799246523 0.6934390034496356 0.8816753640763202 1.056716740383785 0.6845887644925472 0.9931137816988452 1.3371980490508424 0.6661569877073514 0.7852158523290476 1.3572145038098122 1.0 13.60429118972368 -4.01232089906753 0.8419713235762303 0.9821772143092004 1.2755680929659065e-37 0.1363277724703803 0.2238048294010102 17.703366413904245 3.8019350007416186 0.07991803314835469 21.954888601838913 9.720287288531703e-05 4.01232089906753 -0.9821772143092004 TGSNISGASSDIS(ph)LDEQYK ddPTM_A459_Selumetinib_30min_R1 1 TGSNISGASSDISLDEQYK 19 0 P22059 P22059 OSBP Oxysterol-binding protein 1 1 TGSNIS(0.015)GAS(0.215)S(0.057)DIS(0.713)LDEQYK 234.82 2.6638999999999997e-24 5206400.0 1256.9 1628.4 1348.2 1164.0 1452.9 1281.8 1662.1 1364.8 845.18 1485.5 True False 1286.1833244983409 1437.7461709773775 1165.1218451325003 960.729250986125 1321.4854515303298 1268.906255781281 1536.7264588356138 1328.6010705048122 1434.2087304951503 1676.1783949953387 0.7673308093807746 0.8577524774631018 0.6951061107882496 0.5731664683512381 0.7883918892380215 0.7570233929574124 0.9168036429916443 0.7926370334277617 0.8556420574190367 1.0 10.710959987326284 -7.1393333074079255 4.322155987005277 0.873697093203984 0.73492390356529 0.42915480469352973 0.08468568410471794 0.2716991730158893 8.310180578806778 0.035212719036369036 0.026940765566825616 7.255489076490119e-08 7.1393333074079255 -0.138773189638694 TGSPGDAPERPPLCDFSEGLS(ph)APMDFYR ddPTM_A459_Selumetinib_30min_R1 1 TGSPGDAPERPPLCDFSEGLSAPMDFYR 28 1 Q8IWE5;Q5VVD7;A0A2R8Y575 Q8IWE5 PLEKHM2 Pleckstrin homology domain-containing family M member 2 1 T(0.1)GS(0.12)PGDAPERPPLCDFS(0.029)EGLS(0.749)APMDFY(0.002)R 48.115 0.020855 6356500.0 288.57 626.91 566.35 568.98 380.61 543.96 466.0 302.8 218.06 355.94 True False 295.29311954052525 553.5110857574482 489.44278073786666 469.6183240773933 346.18389270215306 538.4882562761632 430.84924482124745 294.7687603669821 370.03189352773654 401.6283661492029 0.7352397002527091 1.3781673118970428 1.2186459473234545 1.1692857468711073 0.8619508029807523 1.3407625099769906 1.0727560131078717 0.7339341172368213 0.9213290810994947 1.0 8.649717357115136 -7.605294709254608 7.092445071307394 0.8731512164724596 1.1311722968937141 0.2193764776753706 0.19524871131405086 0.3032392908868135 21.82517435921135 0.08971253681214793 0.051401881438512376 2.4814486398114795e-08 7.605294709254608 0.2580210804212545 TGSPGS(ph)PGAGGVQSTAK ddPTM_A459_Selumetinib_30min_R1 1 TGSPGSPGAGGVQSTAK 17 0 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 T(0.004)GS(0.017)PGS(0.83)PGAGGVQS(0.074)T(0.074)AK 107.62 0.002426 6765800.0 1550.1 1877.6 1813.2 1789.7 1483.1 1448.4 1815.9 1531.9 1057.6 1442.4 True False 1586.214314030453 1657.7697191274408 1566.9773991946665 1477.1624918297837 1348.9538668625714 1433.830411041978 1678.9252010105236 1491.2690356875164 1794.6699559521878 1627.546090165786 0.9746048505875966 1.0185700602546846 0.9627852683637673 0.9076010201832848 0.8288268301668579 0.8809768397378686 1.0315684521348971 0.9162683900003176 1.102684567150647 1.0 10.668482684035848 -8.252537849256141 24.85402606639663 1.0513422862718842 0.9397977847811279 0.336497988186958 0.062452917100567676 650.3015769268005 1815724.3713950573 0.04719248314967482 0.017254940970685573 5.59064802316434e-09 8.252537849256141 -0.11154450149075634 TGSPGS(ph)PGAGGVQSTAK ddPTM_A459_Selumetinib_30min_R2 4 TGSPGSPGAGGVQSTAK 17 0 O43237-2;O43237;J3KRZ2;J3KRI4 O43237-2 DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 2 1 T(0.004)GSPGS(0.996)PGAGGVQSTAK;TGSPGS(1)PGAGGVQSTAK;T(0.228)GS(0.142)PGS(0.63)PGAGGVQSTAK;T(0.028)GS(0.007)PGS(0.965)PGAGGVQSTAK 287.31 1.3638e-75 70561400.0 176389.0 142225.0 173433.0 207094.0 219984.0 167163.0 187786.0 183235.0 153608.0 187151.0 True False 166586.00552111285 153133.2001745462 162274.50959957312 178887.4399429234 192347.64323808762 190188.1858953709 196518.42109089985 183768.1835138127 184333.89216612285 181747.4643533049 0.916579530360219 0.8425603114707861 0.8928570760366832 0.9842637451886437 1.058323668627237 1.0464420319265517 1.0812718724310848 1.0111182797938774 1.0142308880182784 1.0 17.471575710986464 -5.864750625467966 2.806963138189698 1.0381745563209066 0.8765116863181271 0.8503034029326632 0.028337324497803514 0.08977549910728468 1.4273786437806353 0.008473507330598491 0.013925578023308629 1.3653669135258711e-06 5.864750625467966 -0.16166287000277946 TGSPT(ph)FVR ddPTM_A459_Selumetinib_30min_R1 1 TGSPTFVR 8 0 Q9UPP1-4;Q9UPP1-3;Q9UPP1-2;Q9UPP1;Q9UPP1-5;B0QZZ4;Q5JPR8;B0QZZ2;B0QZZ3;B0QZE1 Q9UPP1-4 PHF8 Histone lysine demethylase PHF8 1 T(0.019)GS(0.227)PT(0.755)FVR 106.68 0.031859 5430300.0 5141.8 5974.1 5453.0 6145.0 7360.1 5134.4 6401.8 4554.7 2554.9 4070.2 True False 5261.593935798842 5274.649594716259 4712.51255118493 5071.891105936202 6694.3802545311955 5082.752597662202 5918.907071881252 4433.8945602493195 4335.478697486996 4592.64981710537 1.1456553722432707 1.148498101264062 1.0260988185149955 1.1043496255790923 1.4576291511706183 1.1067145983417763 1.2887782233768887 0.9654327538179016 0.9440037603867515 1.0 12.16511106900787 -7.78120536036322 24.522574996182527 0.9660384596654717 1.1798639095501673 0.42677891731734463 0.11291861269691124 201.91225509826197 250497.13359285795 0.06377641843502975 0.030708962026769596 1.6549872016458993e-08 7.78120536036322 0.21382544988469554 TGSQGQCTQVR ddPTM_A459_Selumetinib_30min_R2 1 TGSQGQCTQVR 11 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 141.71 0.013594 3129700.0 803.25 2366.1 2518.5 2627.5 2895.3 2059.3 2681.8 3096.4 1273.0 3526.3 False True 758.6085806645202 2547.572261789375 2356.462451935468 2269.6299673096846 2531.5665296895913 2342.949882535833 2806.5090138858873 3105.4100113633867 1527.6355705918568 3424.4865565722885 0.22152476528447618 0.7439282414176992 0.688121390756502 0.6627650393177341 0.7392543342975018 0.6841755234924879 0.8195415480605768 0.9068249969921685 0.4460918579633529 1.0 11.741671981402403 -4.760947522170052 24.955928773313765 0.7366497716475934 0.22152416827054944 0.5499856029912094 0.14150447696845234 8.46404176776431 429013.0282071077 0.03281722796220616 0.18832589204304048 1.7340135140443937e-05 4.760947522170052 -0.5151256033770439 TGSSS(ph)PPGGPPKPGSQLDSMLGSLQSDLNK ddPTM_A459_Selumetinib_30min_R1 1 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNK 30 1 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;P49023-4 A0A1B0GTU4 PXN Paxillin 1 T(0.032)GS(0.129)S(0.174)S(0.665)PPGGPPKPGS(0.001)QLDSMLGSLQSDLNK 119.88 4.708e-16 611510000.0 2356.6 2675.2 2630.3 2871.6 2333.2 1969.6 2344.3 2048.3 1294.1 1764.8 True False 2411.5041948546336 2361.98634033326 2273.1197072036903 2370.128966608039 2122.1624719599163 1949.7876122537139 2167.4675635932435 1993.9724301839155 2195.9931826756106 1991.3292706077239 1.2110022337584978 1.1861355001387677 1.1415087101642252 1.190224540758501 1.0657014403812104 0.9791387296078201 1.088452620862528 1.0013273342662135 1.1027775341269535 1.0 10.95951607819489 -6.336780022472784 4.264297951349732 1.0365996787069773 1.1799123575122854 0.7578521080284268 0.039719440456214714 0.10786018586761803 3.7288911750695655 0.011964593714565945 0.0138219041125839 4.604897604002683e-07 6.336780022472784 0.14331267880530807 TGSSSPPGGPPKPGS(ph)QLDSMLGSLQSDLNK ddPTM_A459_Selumetinib_30min_R1 3 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNK 30 1 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;P49023-4 A0A1B0GTU4 PXN Paxillin 1 T(0.001)GS(0.001)S(0.002)S(0.016)PPGGPPKPGS(0.967)QLDS(0.013)MLGS(0.001)LQSDLNK;TGSS(0.001)S(0.002)PPGGPPKPGS(0.854)QLDS(0.063)MLGS(0.063)LQS(0.016)DLNK;T(0.009)GS(0.026)S(0.07)S(0.064)PPGGPPKPGS(0.386)QLDS(0.288)MLGS(0.13)LQS(0.028)DLNK 80.832 1.0555e-05 752993000.0 11174.5 13490.800000000001 14954.1 15675.4 12762.099999999999 12346.000000000002 12195.9 11749.7 7862.9 10459.5 True False 11434.844108208057 11911.290864297227 12923.415356991487 12937.98565370096 11607.770308331761 12221.81044927111 11275.953444024579 11438.059787595543 13342.76701650573 11802.078709157684 0.9688839051154035 1.0092536372473775 1.0950117920297986 1.096246345456236 0.9835360866831746 1.0355642213932823 0.9554209662468304 0.9691563723194215 1.1305438088760218 1.0 13.526753364498823 -6.297531419048307 24.983427740234752 1.009140301254731 1.0437466724717044 0.05974159341056906 0.05730547400262682 1732.6519609063805 1199363.322222992 0.018393695046221306 0.02085676231255851 5.040441526931122e-07 6.297531419048307 0.0346063712169733 TGSSSPPGGPPKPGSQLDS(ph)MLGSLQSDLNK ddPTM_A459_Selumetinib_30min_R1 1 TGSSSPPGGPPKPGSQLDSMLGSLQSDLNK 30 1 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;P49023-4 A0A1B0GTU4 PXN Paxillin 1 TGSSSPPGGPPKPGS(0.044)QLDS(0.37)MLGS(0.216)LQS(0.37)DLNK 74.446 2.7502e-05 15216000.0 1519.0 1614.5 1908.3 1517.7 1364.1 1453.4 1426.8 1189.7 812.69 997.1 True False 1554.38974454052 1425.4735894393123 1649.163341541574 1252.6621857574246 1240.7173958514152 1438.780115581615 1319.1753272767294 1158.1452913097705 1379.075573470863 1125.087497576473 1.3815723202762433 1.266989094190358 1.4658089660528641 1.1133909037792684 1.1027741384772456 1.2788161975676209 1.1725090982864328 1.0293824203046489 1.225749620755275 1.0 10.135821488247531 -1.5228787452821788 0.15086212504898516 0.9845917693584497 2.473456857885985 0.4975245275917507 0.10066459279569176 58.81031265579023 0.5829311244900613 0.35602869264751025 19.179311334803153 0.029999999999872812 1.5228787452821788 1.4888650885275352 TGST(ph)SSKEDDYESDAATIVQK ddPTM_A459_Selumetinib_30min_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 T(0.005)GS(0.018)T(0.326)S(0.326)S(0.326)KEDDYESDAATIVQK 90.442 0.0010186 143530000.0 9097.6 12291.0 14456.0 15635.0 8728.3 13741.0 11557.0 12451.0 8495.9 10422.0 True False 9309.556379151962 10851.964006069127 12492.954601124036 12904.640755299033 7938.826806106525 13602.77801582976 10685.246185405918 12120.759033452094 14416.92178401493 11759.765218876759 0.7916447485029952 0.9228044781582518 1.0623472806302598 1.0973553055791048 0.6750837842717413 1.1567219041069459 0.9086275096933037 1.0306973657939928 1.2259531985275445 1.0 13.521571636922419 -8.005350706087851 7.526550441814988 1.1185393940289212 0.9532516050900828 0.18078300186486396 0.14355469664352238 0.21151896392449568 85.31841828047783 0.08426610666954061 0.03635277475628714 9.877551300072866e-09 8.005350706087851 -0.16528778893883844 TGSTPSIAS(ph)THSELSTYSNNSGNAAVIK ddPTM_A459_Selumetinib_30min_R2 1 TGSTPSIASTHSELSTYSNNSGNAAVIK 28 0 Q9ULD2 Q9ULD2 MTUS1 Microtubule-associated tumor suppressor 1 1 T(0.079)GS(0.253)T(0.021)PS(0.025)IAS(0.494)T(0.117)HS(0.011)ELSTYSNNSGNAAVIK 93.712 2.5559e-06 3766300.0 8932.1 6444.7 7938.6 9764.3 14504.0 6757.3 8917.1 9936.9 6708.0 9492.9 True False 8435.689640029328 6938.987767023363 7427.839118894145 8434.385495642991 12681.877852594847 7688.056738337974 9331.762818898444 9965.814733857644 8049.787437180033 9218.815311483731 0.9150513764519312 0.752698425184804 0.8057259927575948 0.9149099109444585 1.3756515803931155 0.8339527887884991 1.0122518462078327 1.0810298717497233 0.8731910950805729 1.0 13.170365649843621 -6.004869384502756 24.481333694054666 1.0339103314325178 0.8244800632989691 0.2998653640755673 0.14147349793652786 197.22455576845218 991582.5915235882 0.039647365726259785 0.057027452420590125 9.888504499723401e-07 6.004869384502756 -0.2094302681335487 TGSTS(ph)SKEDDYESDAATIVQK ddPTM_A459_Selumetinib_30min_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 T(0.037)GS(0.154)T(0.029)S(0.662)S(0.118)KEDDYESDAATIVQK 105.2 8.1668e-05 97397000.0 2515.6 3426.8 4168.3 4432.5 2368.8 3873.9 3106.8 3751.2 2299.6 2836.0 True False 2574.2085854944903 3025.588662923902 3602.267754832964 3658.4470833298988 2154.542458245608 3834.932083219776 2872.451574700972 3651.70599038515 3902.2532438612425 3200.02822497932 0.8044330876210087 0.9454881176691667 1.1256987443778699 1.1432546296848807 0.673288579590429 1.1984057057010986 0.897633199694523 1.141148056720265 1.2194433828428062 1.0 11.643868914730385 -7.7799011791383785 24.71020292491828 1.1352219219202022 0.9788746950666363 0.1542576524560928 0.15928367188184112 404.2599249333625 541073.0887684011 0.08510774179507272 0.04100692417507921 1.6599645785228416e-08 7.7799011791383785 -0.15634722685356595 TGSTSS(ph)KEDDYESDAATIVQK ddPTM_A459_Selumetinib_30min_R2 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 T(0.208)GS(0.181)T(0.181)S(0.181)S(0.242)KEDDY(0.004)ESDAAT(0.001)IVQK 54.875 0.018639 26292000.0 40007.0 33521.0 32072.0 30783.0 26373.0 20258.0 26723.0 30330.0 19123.0 36010.0 True False 37783.57110071016 36091.95291299673 30008.52243735333 26590.302296363076 23059.787962388567 23048.355616185552 27965.67245061995 30418.25527859819 22948.13434126322 34970.29773478381 1.080447509691291 1.0320745103950673 0.8581145824075966 0.7603681986932177 0.6594106843835005 0.6590837684879105 0.7996978653917325 0.8698311781412759 0.6562178713862497 1.0 15.093842458646776 -5.346766873115671 2.208577847721488 0.7585911543638818 1.0780001026836619 0.5496679411228909 0.10145092796508923 0.23138810216445924 2.1246961083646987 0.02811960870056639 0.08839798323791176 4.500213590537445e-06 5.346766873115671 0.31940894831978006 TGT(ph)PSDPRR ddPTM_A459_Selumetinib_30min_R2 1 TGTPSDPRR 9 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 T(0.053)GT(0.946)PS(0.001)DPRR 88.134 0.039436 6430000.0 54352.0 44613.0 45888.0 37781.0 40178.0 30805.0 66859.0 41010.0 32388.0 48437.0 True False 51331.333428294995 48034.6736465954 42935.616039076725 32635.16262413976 35130.48044412272 35048.109130052144 69968.07597859511 41129.332310429025 38866.50499633077 47038.497955560226 1.0912621716108035 1.02117788055172 0.912776085657333 0.6937968694275046 0.7468452856915702 0.7450941389149789 1.4874640777156123 0.8743759707056568 0.8262701124736174 1.0 15.52155437198005 -10.64952779070918 16.71820622667387 1.0000008162520386 0.9317270025620448 0.008202890369718663 0.2197020444808357 0.0 0.0 0.223272640611663 0.05415156944426224 2.2411566285216925e-11 10.64952779070918 -0.06827381368999386 TGTGDIATCYS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TGTGDIATCYSPR 13 0 Q9NZN5-2;E9PMR6;Q9NZN5 Q9NZN5-2 ARHGEF12 Rho guanine nucleotide exchange factor 12 1 TGTGDIATCYS(1)PR;TGTGDIATCYS(1)PR 168.0 0.00029138 17036700.0 31192.0 24423.0 30277.0 32604.0 35689.0 27429.0 26418.0 28762.0 25618.0 33232.0 True False 29458.47351146927 26296.165567677548 28329.01078310511 28163.278954962858 31205.42875629188 31207.095774328835 27646.48934627391 28845.69265819457 30742.315826725997 32272.505812894608 0.9128040345630373 0.8148163554492509 0.8778063577506938 0.8726709700896578 0.9669354136059564 0.9669870680404344 0.8566576610616844 0.8938163285315502 0.9525853370345597 1.0 14.97801798041378 TGTITTFEHAHNMR ddPTM_A459_Selumetinib_30min_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 ; 118.61 0.001261 56575000.0 8299.2 10593.0 10540.900000000001 12214.2 10097.900000000001 9743.1 8245.1 7754.200000000001 4621.7 5832.299999999999 False True 8492.555212567926 9352.766635447906 9109.503677019115 10081.219258930185 9184.546727929046 9645.093260027003 7623.16546883191 7548.533426808627 7842.687344387505 6580.932516412867 1.2904789999574477 1.4211916946606087 1.3842268788351777 1.5318830931311926 1.3956299817727589 1.4656119381215518 1.1583716213195792 1.14703097288759 1.1917288811012448 1.0 12.684076312616973 -7.296535907310574 6.987163848102142 1.1350865652241644 1.4181950441159354 0.7853531411152812 0.07432694727641019 0.1046672553280423 16.60780016738851 0.030402008413922245 0.02069641742016321 5.052008733879939e-08 7.296535907310574 0.28310847889177104 TGTITTFEHAHNMR ddPTM_A459_Selumetinib_30min_R2 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 ; 163.71 0.00015004 9031400.0 64340.0 76523.0 78078.0 73373.0 84304.0 59406.0 47127.0 55193.0 44336.0 81427.0 False True 60764.24037342696 82392.06803977354 73054.54648489866 63379.47082451505 73712.97783267753 67588.63726602428 49318.498880378924 55353.60249230701 53204.43885134372 79075.99093724632 0.7684284402031544 1.0419353214954818 0.9238524313008458 0.8015008104648625 0.9321789959126177 0.8547301964215883 0.6236848668708742 0.7000051701689697 0.6728267103673234 1.0 16.270952109473825 -7.0745198472700475 6.499236074254059 0.7247902576638219 0.8980324942405077 0.24358158243214378 0.11746468502075093 0.28256838085830255 20.254639670029928 0.04292212257840471 0.03334228739527002 8.423258962416246e-08 7.0745198472700475 0.1732422365766858 TGTLQDLIQHGS(ph)PINNECHPSLER ddPTM_A459_Selumetinib_30min_R2 3 TGTLQDLIQHGSPINNECHPSLER 24 0 A0A2R8YH03;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 1 TGTLQDLIQHGS(1)PINNECHPSLER;T(0.005)GT(0.005)LQDLIQHGS(0.99)PINNECHPSLER;T(0.001)GT(0.001)LQDLIQHGS(0.999)PINNECHPSLER 92.792 1.5299e-05 14140600.0 33920.8 33000.5 45326.8 77877.0 73120.0 52523.0 42465.2 50159.0 49601.0 60303.0 True False 32035.617731721188 35531.532236668034 42410.52303608838 67270.01825468181 63934.01189890616 59757.56649367722 44439.91594319745 50304.95438573054 59522.58596773505 58561.89570398966 0.547038604994112 0.6067346661089622 0.7241999687042076 1.1486994648313422 1.0917339872682863 1.020417214561005 0.7588537804142477 0.8590048833119212 1.016404698860866 1.0 15.837674635331213 -5.569626736899425 5.283081503630034 0.9752084919049175 0.5951815294424295 0.7172854474071391 0.10562285230942946 0.1113282918967296 7.057478821404961 0.03298109741962008 0.059415603521643205 2.693849091870645e-06 5.569626736899425 -0.380026962462488 TGTPTVSSNSHS(ph)HSEK ddPTM_A459_Selumetinib_30min_R1 1 TGTPTVSSNSHSHSEK 16 0 A0A087WV20;A0A087WTU9;Q8TCU4-3;Q8TCU4-2;Q8TCU4 A0A087WV20 ALMS1 Alstrom syndrome protein 1 1 TGTPT(0.004)VS(0.004)S(0.097)NS(0.097)HS(0.4)HS(0.4)EK 83.081 0.019047 26194000.0 1875.7 3434.1 2410.5 4302.9 9592.8 1888.6 3598.5 1542.6 1166.6 1224.7 True False 1919.4001605231404 3032.0339755302234 2083.1673399287147 3551.479290436596 8725.132933746392 1869.6023987115984 3327.062247831029 1501.6852369290189 1979.6349949071691 1381.902174588213 1.3889551632662378 2.1941017470601536 1.5074636817540783 2.5699932714085825 6.313857155877446 1.3529194997241487 2.4075960722924874 1.0866798421360755 1.432543512348891 1.0 10.432439775039674 -5.7671986926333725 24.633816617628945 2.443825909750496 1.7465663457854737 0.029436884780426498 1.4669343768638043 453.22280826539077 1938542.9689240581 0.43535789660326796 0.6662915656655695 1.7092331505702948e-06 5.7671986926333725 -0.6972595639650225 TGVSPGDVS(ph)DSATSDSTK ddPTM_A459_Selumetinib_30min_R1 2 TGVSPGDVSDSATSDSTK 18 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 TGVSPGDVS(0.92)DS(0.079)AT(0.001)SDSTK;TGVSPGDVS(0.995)DS(0.005)ATSDSTK 256.33 9.216099999999999e-35 12367800.0 4539.7 4713.7 4750.9 5104.6 4844.5 4307.1 5271.0 4702.8 2357.6 4588.700000000001 True False 4645.466177281497 4161.817812660324 4105.753874825688 4213.177435209433 4406.31583036594 4263.774484533905 4873.404226293552 4578.066467152721 4000.6750077088477 5177.704342723065 0.897205763363141 0.8037959561189498 0.792968003396344 0.8137153372093922 0.8510172730427796 0.8234874381204036 0.9412287577105117 0.884188467344008 0.7726735137612759 1.0 12.338096871478859 -7.2259867907157975 24.32162417039301 0.8898717362899945 0.8276393430513895 0.23553872478002014 0.05991764569129054 703.3070807771928 482491.81808070716 0.02243636088689888 0.017378151279486394 5.943102345841476e-08 7.2259867907157975 -0.062232393238604966 TGVSPGDVS(ph)DSATSDSTK ddPTM_A459_Selumetinib_30min_R2 2 TGVSPGDVSDSATSDSTK 18 0 Q5T5U3;A0A087WW76;A0A452Q6Z5 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 TGVSPGDVS(0.984)DS(0.015)AT(0.001)SDSTK;TGVSPGDVS(0.937)DS(0.056)AT(0.008)SDSTK 199.31 1.303e-21 6350900.0 58419.0 49309.0 64441.0 68028.0 68954.0 55914.0 44745.0 57911.0 48305.0 52846.0 True False 55172.30584978596 53090.84174657546 60294.93621805577 58762.46904515446 60291.38206341874 63615.64596324412 46825.731160535455 58079.511422317846 57967.34975446947 51320.198669602476 1.0750602546374226 1.0345018749512704 1.1748772955115065 1.1450163983866284 1.1748080410127095 1.2395830026457861 0.9124230298093303 1.1317086240494034 1.129523097283023 1.0 15.647239134916552 -10.636428752495872 7.309437008117906 0.9999999623306011 1.1136889153167087 0.13584144529145914 0.08553154183969781 5.3590409139991405e-08 6.5416058167342096e-09 0.08444315463501159 0.020480466575428215 2.309783355746041e-11 10.636428752495872 0.1136889529861076 TGYES(ph)GEYEMLGEGLGVK ddPTM_A459_Selumetinib_30min_R1 2 TGYESGEYEMLGEGLGVK 18 0 Q13561;Q13561-3;Q13561-2;F8VW18;F8W1I6;H0YHL1;F8VX93;F8VRV7 Q13561 DCTN2 Dynactin subunit 2 1 T(0.042)GYES(0.958)GEYEMLGEGLGVK;TGYES(1)GEYEMLGEGLGVK 241.68 5.670199999999998e-66 8457700.0 2426.77 3051.0 2813.78 2782.6 2871.65 2690.5 2973.32 2501.41 1556.95 2355.13 True False 2483.30901932758 2693.7875016285807 2431.68413098719 2296.6711458711266 2611.9097645309853 2663.436012778543 2749.0400785663346 2435.0644810752065 2642.030434871179 2657.4338764088657 0.934476316183419 1.0136799735799416 0.9150497224311962 0.8642439483667389 0.9828691459524105 1.0022586211544005 1.0344716769702889 0.9163217578778822 0.9942036407097729 1.0 11.37581807900968 -6.482793095705433 24.985978265225093 0.9876493883642481 0.9348870317472243 0.2838539408072597 0.04391052668324549 789.0978044702509 491856.72868434235 0.01437354017369624 0.016295870471495413 3.2900833796745526e-07 6.482793095705433 -0.052762356617023776 TGYES(ph)GEYEMLGEGLGVK ddPTM_A459_Selumetinib_30min_R2 1 TGYESGEYEMLGEGLGVK 18 0 Q13561;Q13561-3;Q13561-2;F8VW18;F8W1I6;H0YHL1;F8VX93;F8VRV7 Q13561 DCTN2 Dynactin subunit 2 1 T(0.053)GYES(0.947)GEYEMLGEGLGVK 93.152 0.010161 0.0 3322.1 1996.1 3359.9 4700.1 2560.1 2928.9 3848.6 3613.0 2313.3 2186.8 True False 3137.470981419981 2149.1944515268865 3143.7276919825235 4059.9382718752604 2238.477350415615 3332.3293890929926 4027.5675258562223 3623.5132318356495 2776.0246390024695 2123.661402011254 1.477387580924426 1.0120231264228146 1.480333771195915 1.9117634609878105 1.0540650916834589 1.5691434547602772 1.8965205668106215 1.7062575175138244 1.3071879709135283 1.0 11.052338044881354 -5.4961743641250544 23.249771386819184 1.536649880236189 1.2450733655810942 0.0779786076695701 0.31334580595627204 614.2774202209591 534807.8163537652 0.08031273658565541 0.16613982686537893 3.1902567473920967e-06 5.4961743641250544 -0.2915765146550948 THAPSALS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 THAPSALSPPR 11 0 H9KVB4;O15417;O15417-2 H9KVB4 TNRC18 Trinucleotide repeat-containing gene 18 protein 1 THAPS(0.006)ALS(0.994)PPR 87.363 0.021274 7385700.0 2019.9 2278.4 2685.8 3205.0 2598.0 2059.1 2361.2 2217.3 1099.7 1990.4 True False 2066.959739958784 2011.6438688005758 2321.0831120433686 2645.3069153011443 2363.011358714153 2038.3873235132141 2183.0927829869734 2158.4900011945483 1866.1105810898457 2245.887228137812 0.9203310451489648 0.89570119265006 1.0334815938055382 1.1778449434856588 1.0521504949620535 0.9076089386746958 0.9720402501229303 0.9610856565510951 0.8309012837822405 1.0 11.133069772734109 -6.764024992527876 24.998860099208756 0.9342521388925762 1.0191975321371278 0.19297072430387474 0.08327478129972715 129.7771618440619 1254733.4275730026 0.03181896326997654 0.029350906453628454 1.7217694887393878e-07 6.764024992527876 0.08494539324455164 THAPSALS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 1 THAPSALSPPR 11 0 H9KVB4;O15417;O15417-2 H9KVB4 TNRC18 Trinucleotide repeat-containing gene 18 protein 1 THAPS(0.004)ALS(0.996)PPR 73.834 0.037437 7504600.0 11004.0 7771.4 10694.0 12295.0 12525.0 6576.0 7118.2 9157.3 8567.1 11292.0 True False 10392.441732502175 8367.441391010503 10005.959682746832 10620.39978994199 10951.497525079318 7481.784309015512 7449.210404445718 9183.946226927374 10280.759384774155 10965.970619860555 0.9476992135726082 0.7630370061229387 0.9124554523814755 0.96848698196467 0.9986801811455682 0.6822728756417781 0.6793024222547519 0.8374950604275975 0.9375147664680582 1.0 13.420745893018825 -6.7477836259839865 24.99587073315953 0.807909522389195 0.911947525388867 0.1326774634504707 0.11003091925358938 445.06431703248546 814656.4765493635 0.03798606746553243 0.03778869163056405 1.787377859708288e-07 6.7477836259839865 0.10403800299967203 THAVS(ph)VSETDDYAEIIDEEDTYTMPSTR ddPTM_A459_Selumetinib_30min_R1 2 THAVSVSETDDYAEIIDEEDTYTMPSTR 28 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;Q05397-4;Q05397-3;H0YB33;H0YB99 E7ESA6 PTK2 Focal adhesion kinase 1 1 T(0.011)HAVS(0.734)VS(0.254)ET(0.001)DDYAEIIDEEDTYTMPSTR;T(0.039)HAVS(0.895)VS(0.066)ETDDYAEIIDEEDTYTMPSTR 182.79 5.663600000000001e-27 33390000.0 1830.19 2204.85 2728.2 2073.88 2878.2 2375.27 2241.03 2173.43 1329.24 1595.1599999999999 True False 1872.8298660701864 1946.705136993043 2357.725424929897 1711.71578954906 2617.8673181874806 2351.376940372604 2071.987302836396 2115.783576104392 2255.6231961515564 1799.914324174192 1.0405105625954993 1.0815543333631723 1.3099098069635238 0.950998481738514 1.4544399602956484 1.306382703216402 1.151158849623041 1.1754912707165226 1.2531836464974218 1.0 10.813712520644401 -5.089162653776421 6.822517798694124 1.20850188776849 1.0502482749875712 0.13673655255722383 0.14022683055397375 0.4042610334428488 25.860566567717008 0.03470549927226512 0.09459050952011214 8.143992147139582e-06 5.089162653776421 -0.15825361278091887 THAVSVSETDDY(ph)AEIIDEEDTYTMPSTR ddPTM_A459_Selumetinib_30min_R1 4 THAVSVSETDDYAEIIDEEDTYTMPSTR 28 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;Q05397-4;Q05397-3;H0YB33;H0YB99 E7ESA6 PTK2 Focal adhesion kinase 1 1 THAVSVSETDDY(1)AEIIDEEDTYTMPSTR;THAVSVSETDDY(1)AEIIDEEDTYTMPSTR;THAVSVSETDDY(1)AEIIDEEDTYTMPSTR;THAVSVSETDDY(1)AEIIDEEDTYTMPSTR 255.99 4.2621999999999987e-63 44364700.0 5326.1 6095.5 5461.959999999999 7134.9 2826.9100000000003 4362.5199999999995 2238.78 1989.98 1534.05 1209.7 True False 5450.18776721347 5381.83602627893 4720.255832398689 5888.9236536605695 2571.216489631497 4318.637009651238 2069.9070221478805 1937.1992660339745 2603.1708074210037 1364.976778475841 3.9928794783595167 3.942804090988559 3.45812171080992 4.314303178282823 1.883707129803751 3.1638904615458077 1.5164411986987631 1.4192177453722605 1.9071172846821274 1.0 10.414660692318046 -6.735336713927774 0.7154181390482318 1.2793044968586007 4.085838740904227 0.7812228299202593 0.5499055789393567 0.31211710907295526 0.3519704083433004 0.3802478301976596 0.39437122771890787 1.8393453810902572e-07 6.735336713927774 2.806534244045626 THCAATPSSSEDTETVSNS(ph)SEGR ddPTM_A459_Selumetinib_30min_R1 2 THCAATPSSSEDTETVSNSSEGR 23 0 H0YEM7;O75143-4;O75143-3;O75143-2;O75143;O75143-5 H0YEM7 ATG13 Autophagy-related protein 13 1 THCAATPSSSEDTETVS(0.003)NS(0.882)S(0.115)EGR;THCAATPSSSEDTETVS(0.025)NS(0.859)S(0.116)EGR 285.62 9.980399999999996e-80 12010900.0 2105.33 2679.07 2556.48 2525.55 2700.08 2076.25 2985.4900000000002 2255.33 850.3699999999999 1939.72 True False 2154.3800927409425 2365.403238934147 2209.3240577394577 2084.5101029450243 2455.858240737842 2055.3648100841674 2760.2920856682126 2195.5113220556996 1443.0157814325469 2188.7019564728084 0.9843186215325648 1.0807333688987515 1.009422069188389 0.9523955953803349 1.1220615184607263 0.9390793497514299 1.261154849112735 1.0031111433709616 0.6593020932635486 1.0 11.095859795510917 -8.023071898348649 24.347616334136987 0.8301694506380666 1.0505519206201661 0.35587709109099397 0.1168569715650432 555.6243300518286 586341.9115200428 0.07256375042697065 0.027882554967776578 9.48261463661212e-09 8.023071898348649 0.22038246998209954 THCAATPSSSEDTETVSNS(ph)SEGR ddPTM_A459_Selumetinib_30min_R2 1 THCAATPSSSEDTETVSNSSEGR 23 0 H0YEM7;O75143-4;O75143-3;O75143-2;O75143;O75143-5 H0YEM7 ATG13 Autophagy-related protein 13 1 THCAATPSSSEDTET(0.001)VS(0.074)NS(0.787)S(0.138)EGR 173.34 5.6255e-13 7346500.0 17265.0 15119.0 20433.0 16944.0 23270.0 14971.0 11590.0 19426.0 13576.0 16896.0 True False 16305.480417271012 16278.57868475278 19118.363025768293 14636.197969969666 20346.61456356053 17033.119356793068 12128.957965149308 19482.526443852585 16291.579345133581 16408.16857891995 0.9937416439162585 0.9921021109977101 1.165173488668943 0.8920068013424248 1.2400295904870466 1.0380877838295743 0.7392024226720666 1.187367520643489 0.9928944395454252 1.0 14.002126598927587 -7.017833898445727 24.98770452846535 0.9802179350562306 1.0588280433103243 0.06793976145449565 0.13498619282243915 2245.6395613892305 3146440.326300643 0.04997857802373193 0.039570509279092426 9.59767636902477e-08 7.017833898445727 0.07861010825409376 THCVGDSQSSASS(ph)PPATSK ddPTM_A459_Selumetinib_30min_R2 2 THCVGDSQSSASSPPATSK 19 0 Q9H4Z2-2;Q9H4Z2 Q9H4Z2-2 ZNF335 Zinc finger protein 335 1 THCVGDSQSSAS(0.038)S(0.962)PPATSK;THCVGDSQSSAS(0.008)S(0.992)PPATSK 148.44 2.4029e-05 20316700.0 77662.0 57954.0 81387.0 92884.0 97939.0 71981.0 72721.0 79231.0 63085.0 87754.0 True False 73345.8569456184 62398.88544851922 76150.64902746551 80233.03896616276 85635.02723423102 81895.72937153984 76102.67059392783 79461.54909260187 75703.76274217374 85220.31400772619 0.8606616603051799 0.7322067065237762 0.8935739079835071 0.9414778612396185 1.0048663658581125 0.9609883550078806 0.8930109150622029 0.9324249742308832 0.888330014077516 1.0 16.378909746913443 -5.4722359165607894 4.603222231050186 0.9427192461354867 0.7970463461196688 0.6194277303087712 0.04627211983801642 0.13135357142860146 5.956684075998798 0.012401747985826897 0.025960464857992836 3.371041378917819e-06 5.4722359165607894 -0.1456729000158179 THDHQLESSLS(ph)PVEVFAK ddPTM_A459_Selumetinib_30min_R1 2 THDHQLESSLSPVEVFAK 18 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 T(0.002)HDHQLES(0.014)S(0.014)LS(0.97)PVEVFAK;THDHQLES(0.009)S(0.039)LS(0.951)PVEVFAK 106.63 0.0010895 15681400.0 2893.8 3016.5 3498.8 3799.8999999999996 3238.7 2922.3999999999996 3100.9 2612.0 1410.4499999999998 2520.7 True False 2961.219909645395 2663.3267776671955 3023.682177532706 3136.3187979571976 2945.7601568389255 2893.003309326897 2866.9966164510856 2542.7212750282624 2393.4306348078326 2844.256398697238 1.0411227029327348 0.9363877247097293 1.0630835458145231 1.1026849757264265 1.035687274251428 1.0171387188060776 1.0079951363612167 0.8939845494213923 0.8414960887155256 1.0 11.47383580885139 -7.6944224381183215 4.22565180989578 0.9000611471044243 1.0314235304340669 0.4988962780317271 0.05386004169965923 0.16884502801837784 5.880870135816048 0.028427993448662186 0.015142988329136058 2.0210523452260806e-08 7.6944224381183215 0.13136238332964256 THDHQLESSLS(ph)PVEVFAK ddPTM_A459_Selumetinib_30min_R2 4 THDHQLESSLSPVEVFAK 18 0 Q5JW53;Q9H410-4;Q9H410 Q5JW53 DSN1 Kinetochore-associated protein DSN1 homolog 1 THDHQLESS(0.001)LS(0.999)PVEVFAK;T(0.004)HDHQLES(0.009)S(0.011)LS(0.976)PVEVFAK;THDHQLES(0.038)S(0.169)LS(0.792)PVEVFAK;THDHQLES(0.001)S(0.011)LS(0.988)PVEVFAK 81.357 0.005471899999999999 13199500.0 70650.0 62861.0 77934.0 80308.0 82755.0 60655.6 60623.0 66037.0 51229.7 78318.0 True False 66723.5558343583 67682.2365700274 72919.81128812359 69369.91186097273 72358.57706091325 69010.35832328473 63442.08962219555 66229.15673698616 61477.07147741531 76056.75584539858 0.8772863776886305 0.8898911847831878 0.9587552148075905 0.9120808676349768 0.9513760645799478 0.9073534304245484 0.8341414108058328 0.8707859808221495 0.8083052030562602 1.0 16.214788782551977 -7.063743295697008 8.386141092653242 0.8678267103342238 0.9193685467197582 0.10076203424214547 0.05236935115065469 0.6214624080745779 76.474238161255 0.019008733825204075 0.014757748265827842 8.634887909319002e-08 7.063743295697008 0.051541836385534445 THEAQIQEMR ddPTM_A459_Selumetinib_30min_R1 3 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 ;; 148.32 0.0056081 136622000.0 3490.65 4085.1 4489.1 4712.3 3860.46 3418.3399999999997 3806.73 3623.9199999999996 1898.6599999999999 2941.32 False True 3571.975353377461 3606.814592888535 3879.5048768612282 3889.3852658263927 3511.282074619571 3383.954603204388 3519.5852912840946 3527.8018694488574 3221.887347360232 3318.8670728829943 1.0762634582633643 1.0867607872452119 1.1689244527323674 1.1719014893982505 1.0579761097721314 1.0196113700525085 1.060477932376708 1.0629536501395243 0.9707792679269559 1.0 11.696475132477547 -6.4537836027425834 5.436755844598983 1.029854628291152 1.1258684601492261 0.6180257572335743 0.038098322888494685 0.16596291206508645 9.26649490278371 0.012793684401920592 0.01436139586272307 3.5173565728779206e-07 6.4537836027425834 0.0960138318580741 THEAQIQEMR ddPTM_A459_Selumetinib_30min_R2 1 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 132.25 0.0034734 11500000.0 24732.0 23904.0 25355.0 30052.0 29370.0 21344.0 21291.0 20997.0 16952.0 23658.0 False True 23357.49445004033 25737.359936525598 23723.68690443668 25958.865757408428 25680.27802886861 24283.942258459098 22281.07368731613 21058.097793759538 20342.873678454962 22974.93206913399 1.016651295409935 1.1202366065361662 1.0325900783101167 1.1298778024368241 1.1177520765499525 1.0569755847541207 0.9697993282535083 0.9165684464438678 0.8854378161920616 1.0 14.487772975398105 -7.311479676658904 2.5933079553832403 0.9273049994744228 1.0854061320670416 0.703604422796928 0.0438006182484876 0.14796259840133824 1.958674114525158 0.020282638675983893 0.013046241526007137 4.8811294255486975e-08 7.311479676658904 0.15810113259261882 THFEYEK ddPTM_A459_Selumetinib_30min_R2 1 THFEYEK 7 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 0 93.195 0.036569 2207500.0 29466.0 23952.0 24309.0 27533.0 27146.0 21819.0 22196.0 19642.0 23886.0 24439.0 False True 27828.397681743856 25789.041382181254 22744.985405637995 23782.957902925784 23735.676791680886 24824.369196838405 23228.157980539607 19699.154968091843 28663.867430602582 23733.382569852307 1.1725424136167302 1.0866146579097486 0.9583541384669778 1.0020888439701996 1.000096666449539 1.0459684422890456 0.9787124912419998 0.8300188525640251 1.2077447176456548 1.0 14.534630112992216 -4.987004706287912 3.2330090010185466 0.9976027079214759 1.1697025226125484 0.272411164779768 0.08768331844767194 0.3128302205693125 6.4131732123670675 0.021542028841411053 0.10594432027419634 1.0303749545906306e-05 4.987004706287912 0.1720998146910725 THHDLTTPAVGGAVLVS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 THHDLTTPAVGGAVLVSPSK 20 0 Q8TC05-4;Q8TC05 Q8TC05-4 MDM1 Nuclear protein MDM1 1 THHDLTTPAVGGAVLVS(0.756)PS(0.244)K 126.43 0.00072875 0.0 459.68 465.66 815.79 773.19 619.82 529.8 537.31 460.71 337.31 513.31 True False 470.3896496184239 411.1403107205393 705.0101988137093 638.166881073851 563.7573904381093 524.4706930199118 496.78027410923704 448.490474203013 572.3904338523383 579.1983385628115 0.8121391556226162 0.7098437328751988 1.2172172326375796 1.1018106209651093 0.9733408280089054 0.9055113906598944 0.8577032098225942 0.7743296973466304 0.9882459871563757 1.0 9.17791365381423 -6.838765162947008 4.549871776939098 0.8860416510077991 0.9706748316470792 0.030323588651910982 0.14420110165339792 0.7071317566609043 27.175303011884196 0.056305834563814106 0.05011384991615563 1.4495554631200936e-07 6.838765162947008 0.08463318063928016 THHNDTELIR ddPTM_A459_Selumetinib_30min_R1 1 THHNDTELIR 10 0 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 0 119.22 0.0076812 3699400.0 426.2 599.6 521.78 457.25 571.0 391.75 339.81 530.0 275.42 507.35 False True 436.1296307591636 529.3985532535227 450.9251419323813 377.3998711455375 519.3531508182382 387.8093506805406 314.17785811739964 515.9426783173733 467.36762411909206 572.4733145074957 0.7618339924444689 0.9247567350959744 0.7876788847709286 0.6592444775704841 0.9072093627019849 0.6774278221408044 0.5488078660709099 0.9012519278060038 0.8164007164616448 1.0 9.161064634207031 -8.631688044041557 1.5595749298940085 0.9960317753680925 0.7649438672269108 0.27334130524547906 0.1134413177006168 0.7403131462465128 3.804934693742193 0.11149426740672626 0.0323856611332589 2.3351347993324655e-09 8.631688044041557 -0.23108790814118174 THNDIIHNENMR ddPTM_A459_Selumetinib_30min_R1 6 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 ;;;;; 184.44 5.8598e-05 74483000.0 6436.31 8296.25 8750.25 8353.38 8371.91 7228.9 7261.799999999999 6456.4 4207.8099999999995 6540.360000000001 False True 6586.263500120865 7324.9211931780155 7562.014111682733 6894.618995362955 7614.672218680759 7156.183829316047 6714.036579491279 6285.155298657148 7140.346243717075 7379.878914501323 0.8924622715935054 0.9925530321079772 1.0246799709441732 0.9342455445732528 1.0318153328665152 0.9696885155194458 0.9097759810527952 0.8516610328533895 0.9675424659998728 1.0 12.849381430096598 -7.200717945088756 5.877990576165149 0.919955159053615 0.9785712063379837 0.11248069095368074 0.052933301357185575 0.34442872163140664 24.765611960609913 0.0200139664219464 0.015318247663840892 6.299151518576088e-08 7.200717945088756 0.058616047284368644 THNDIIHNENMR ddPTM_A459_Selumetinib_30min_R2 4 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 ;;; 190.66 7.765800000000001e-05 46524800.0 53321.0 37690.899999999994 40700.4 35285.2 38363.2 31873.4 36356.5 38542.8 31105.6 35355.299999999996 False True 50357.632280875005 40581.67083465494 38081.78057524494 30479.2948896349 33543.67184464055 36263.67153208259 38047.149289038054 38654.95316689595 37327.589163080986 34334.500624898676 1.4666772885683586 1.1819502277900016 1.1091403655840217 0.8877162718228656 0.9769669351275017 1.056187533590773 1.1081317216376534 1.1258341453454597 1.0871743722409577 1.0 15.06737136016664 -4.7544103222937375 1.7935935574758515 1.0420830828390975 1.6251310464042508 0.78203526121092 0.06833992577208958 0.48322777622443885 1.5125505338575111 0.021217135915542338 0.49472397211260766 1.7603121140915845e-05 4.7544103222937375 0.5830479635651533 THNVHVEIEQR ddPTM_A459_Selumetinib_30min_R2 1 THNVHVEIEQR 11 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 0 92.112 0.014365 1429400.0 3604.4 4713.2 4752.6 6499.5 5170.8 3702.1 3723.1 5171.7 4645.5 5349.1 False True 3404.0818775564194 5074.687284673378 4446.822890239631 5614.256887737125 4521.197876461486 4212.030670682228 3896.23152718269 5186.748790778976 5574.729806115059 5194.657584369118 0.6553043819094843 0.9769050610656735 0.8560377306909037 1.0807751611252672 0.8703553223731064 0.8108389441021784 0.7500458815431009 0.9984775139724437 1.073165981698118 1.0 12.342812938966983 -7.942081634846524 9.225084200370503 1.0363750618328138 0.8691802794677103 0.3223696005713854 0.11071266102386178 0.39108120032256005 58.30245521700548 0.061487484410499185 0.029442693508481665 1.1426635267893032e-08 7.942081634846524 -0.16719478236510354 THPYS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 THPYSPK 7 0 Q15853-3;M0QZ39;M0R1C6;H0YD59;E9PME6;M0QXT0;B1AQP1;B4DLJ1;Q15853-4;P22415-2;P22415;Q15853-2;Q15853 Q15853-3 USF2;USF1 Upstream stimulatory factor 2;Upstream stimulatory factor 1 1 T(0.061)HPY(0.001)S(0.937)PK;THPYS(1)PK;THPYS(1)PK 120.31 0.0095171 43459600.0 19352.6 21446.7 24227.9 21266.2 17760.300000000003 21803.7 16303.400000000001 19205.4 17167.4 19241.1 True False 19803.47792639555 18935.710393699672 20937.88425432851 17552.457386014717 16153.884000835636 21584.374574175636 15073.621412057357 18696.010404068824 29131.823942713327 21710.882609185333 0.9121452261004438 0.8721759835635814 0.9643958115949747 0.808463557284802 0.7440454767141217 0.994173058862371 0.6942887437326055 0.8611354379558483 1.3418074459298295 1.0 14.406130756355202 -8.238371705087578 23.902684027302726 1.1709036460485502 0.8543337057044981 0.5421329268712118 0.11561730905804252 272.3247843197453 282183.71489156666 0.07392727259314213 0.027891723321398644 5.776014767386902e-09 8.238371705087578 -0.31656994034405217 THS(ph)AGTSPTITHQK ddPTM_A459_Selumetinib_30min_R2 1 THSAGTSPTITHQK 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 T(0.012)HS(0.682)AGT(0.039)S(0.266)PT(0.001)ITHQK 101.39 0.0055078 18101000.0 16028.0 10691.0 11123.0 11156.0 11500.0 9985.1 9675.9 9287.4 6270.2 7941.2 True False 15137.227925167666 11510.965323016864 10407.35828980672 9636.53355482658 10055.267188695576 11360.456889286916 10125.848522432116 9314.424796388157 7524.415204025977 7711.916922284504 1.962835969021767 1.492620503957266 1.3495163906308971 1.2495639737742332 1.3038609323759287 1.4731041586378506 1.3130131748660658 1.2077963093032051 0.9756867559456303 1.0 12.91287379467735 -1.5228787452803774 0.6695591400614079 1.2173470996368747 74.94597537066402 0.7405999587330074 0.1351861299686593 134.90572528692633 0.8078303155581015 0.05819595950203328 14805.376434288375 0.02999999999999725 1.5228787452803774 73.72862827102715 THS(ph)EGSLLQEPR ddPTM_A459_Selumetinib_30min_R1 2 THSEGSLLQEPR 12 0 P49796-1;P49796-4;P49796-6;P49796;C9J582 P49796-1 RGS3 Regulator of G-protein signaling 3 1 T(0.37)HS(0.629)EGS(0.001)LLQEPR;T(0.259)HS(0.74)EGS(0.001)LLQEPR 123.72 0.0021353 7212700.0 2247.6 2337.89 2290.04 2378.87 2440.36 1874.8899999999999 3084.58 2168.0299999999997 1109.31 2155.13 True False 2299.964706931712 2064.1687519444245 1979.065146289299 1963.445011420415 2219.6298688805514 1856.030308863916 2851.907647190394 2110.5268016460645 1882.418049203216 2431.7619282438927 0.9458017580662764 0.8488366924286346 0.8138400076517727 0.8074166260339166 0.9127661072000854 0.7632450723514107 1.1727741988500953 0.8679002566547255 0.7740963567772493 1.0 11.247786279169683 THS(ph)FENVSCHLPDSR ddPTM_A459_Selumetinib_30min_R1 2 THSFENVSCHLPDSR 15 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 T(0.226)HS(0.774)FENVSCHLPDSR;T(0.389)HS(0.611)FENVSCHLPDSR 143.33 0.00024992 34720000.0 4908.2 5709.4 5033.9 5288.4 4667.8 5148.299999999999 5124.3 5064.1 3631.2 5931.2 True False 5022.551510305318 5040.9407937719525 4350.3240292334185 4364.8802155627345 4245.598314167023 5096.512776282394 4737.769925402404 4929.78361748492 6161.881187645217 6692.527294780444 0.750471576592963 0.7532193103946581 0.6500270880667564 0.6522020790213198 0.6343789314805185 0.761522897374988 0.7079194027490077 0.7366101624015337 0.9207106547702716 1.0 12.708335402422662 -8.324471163773008 2.181743393890863 1.0008922514743384 0.6985706693266829 0.8543956276376139 0.042868607274376955 0.11263831439029284 1.0192129986166054 0.04408879533665909 0.012544045806214795 4.737277616430314e-09 8.324471163773008 -0.3023215821476555 THS(ph)FENVSCHLPDSR ddPTM_A459_Selumetinib_30min_R2 1 THSFENVSCHLPDSR 15 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 T(0.066)HS(0.934)FENVSCHLPDSR 147.84 0.00020919 19059000.0 32366.0 26365.0 40158.0 42821.0 45051.0 33977.0 24555.0 39842.0 31285.0 40983.0 True False 30567.227291363655 28387.110723163354 37574.278000724466 36988.70592965481 39391.29061894996 38657.023337503044 25696.85615480944 39957.933623801815 37542.8741759358 39799.714303378096 0.7680262993437917 0.7132491079403033 0.9440841136272996 0.9293711419057926 0.9897380247175929 0.9712889656150606 0.6456542868356309 1.0039753883461995 0.9432950671394458 1.0 15.280470454173173 -5.262497488177317 24.995864997028335 0.9222231734710828 0.7406376927051054 0.36255483974417946 0.09932875209955082 99.02662445577265 2339386.1732209944 0.026254742008280825 0.06009824456388509 5.463897100189403e-06 5.262497488177317 -0.18158548076597747 THS(ph)QGGYGSQGYK ddPTM_A459_Selumetinib_30min_R1 2 THSQGGYGSQGYK 13 0 K7ERS0;K7EPH2;K7ER00;Q9Y285-2;Q9Y285 K7ERS0 FARSA Phenylalanine--tRNA ligase alpha subunit 1 T(0.45)HS(0.55)QGGYGSQGYK;T(0.038)HS(0.962)QGGYGSQGYK 158.89 0.00036446 21531700.0 6057.4 7087.8 7045.9 7203.3 6959.2 6308.0 6160.9 5209.5 3175.57 4998.5 True False 6198.525634351376 6257.957080971179 6089.105480358323 5945.378877687593 6329.741588746551 6244.547247205746 5696.178352830953 5071.327137159163 5388.710355543768 5640.106164513095 1.0990086806081405 1.1095459727948973 1.079608309267347 1.0541253487558866 1.1222734828242356 1.1071683874491096 1.009941690223964 0.8991545529882708 0.955427114022945 1.0 12.461506603593788 -7.464639221589971 3.7553063382423124 0.9456809009356668 1.0939989360444604 0.8318370949325626 0.02920759967650126 0.08565665826271256 2.4115414077988073 0.013591376641005045 0.00838674494347931 3.4305264993145595e-08 7.464639221589971 0.1483180351087936 THS(ph)QGGYGSQGYK ddPTM_A459_Selumetinib_30min_R2 1 THSQGGYGSQGYK 13 0 K7ERS0;K7EPH2;K7ER00;Q9Y285-2;Q9Y285 K7ERS0 FARSA Phenylalanine--tRNA ligase alpha subunit 1 T(0.261)HS(0.739)QGGYGSQGYK 104.26 0.005174100000000001 11852000.0 33996.0 30707.0 35567.0 40345.0 40734.0 31817.0 31990.0 28224.0 23889.0 39179.0 True False 32106.63841677062 33062.128161432855 33278.65794242161 34849.94140099304 35616.63075341963 36199.50294403078 33477.59838698243 28306.127167265287 28667.467514429612 38047.80047073297 0.8438500522906076 0.8689629295881327 0.8746539229782845 0.9159515391119711 0.9361022270082752 0.9514216983942624 0.8798826206191336 0.743962247937009 0.7534592580846068 1.0 15.215525434022389 -10.470335744712957 4.67824162985176 1.0000011114492717 0.8669316673389429 0.2796642472772123 0.06564129241390988 52227778.96713287 8.200705408648538 891.6670279666154 0.018027545582731976 3.3858230346736405e-11 10.470335744712957 -0.13306944411032884 THS(ph)TSSSLGSGESPFSR ddPTM_A459_Selumetinib_30min_R1 1 THSTSSSLGSGESPFSR 17 0 F8WBF9;Q5TH30;Q9UGV2-3;Q9UGV2-2;Q9UGV2 F8WBF9 NDRG3 Protein NDRG3 1 T(0.009)HS(0.47)T(0.47)S(0.051)SSLGSGESPFSR 190.18 7.4276e-08 12316000.0 611.07 751.13 798.76 929.77 1155.6 892.27 1323.8 749.08 184.49 488.0 True False 625.3067420647634 663.1873504091368 690.2927792746152 767.4031234444761 1051.0761840377506 883.2945739163395 1223.9447002025058 729.2119650452415 313.066055383528 550.6395535225347 1.1356008446261625 1.2043946828131302 1.2536200402944089 1.393657826676758 1.908827975240496 1.6041248186145622 2.2227693095650753 1.3243000078369758 0.5685498860021793 1.0 9.104964435053756 -5.806384860115758 3.4517108572671575 1.511630416293654 1.1897895709053512 0.04221936758653366 0.43210369470817656 0.6238592549692711 15.227019084831374 0.1308834906483897 0.21579489979669467 1.5617630367373475e-06 5.806384860115758 -0.3218408453883028 THS(ph)TSSSLGSGESPFSR ddPTM_A459_Selumetinib_30min_R2 2 THSTSSSLGSGESPFSR 17 0 F8WBF9;Q5TH30;Q9UGV2-3;Q9UGV2-2;Q9UGV2 F8WBF9 NDRG3 Protein NDRG3 1 THS(0.332)T(0.332)S(0.332)S(0.005)SLGSGESPFSR;T(0.03)HS(0.219)T(0.219)S(0.219)S(0.219)S(0.092)LGSGESPFSR 296.51 5.9767999999999976e-77 73055000.0 24893.0 17723.0 41453.0 49454.0 49271.0 42117.0 28186.0 32172.0 37827.0 49310.0 True False 23509.546714574393 19082.297111573072 38785.959110613854 42718.27988709161 43081.1364916713 47918.23444994012 29496.70484949943 32265.615193638674 45393.45697468831 47886.29217723379 0.4909452297447109 0.3984918490023586 0.809959538463777 0.8920774180841847 0.8996548810298792 1.000667044184338 0.615973872863826 0.6737964817618197 0.9479426138628745 1.0 15.547325111957614 -5.292406187200766 6.453519018355432 0.8440214692959878 0.44405762634533574 0.6396874741297316 0.12299668684568293 0.11230480990578776 16.382926722319276 0.033786563287499 0.07394543290643553 5.100277577685472e-06 5.292406187200766 -0.399963842950652 THSAGTS(ph)PTITHQK ddPTM_A459_Selumetinib_30min_R1 1 THSAGTSPTITHQK 14 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 T(0.004)HS(0.143)AGT(0.035)S(0.818)PTITHQK 144.15 0.000352 23329000.0 5964.0 7452.6 7244.6 7956.3 6954.3 6600.5 5974.7 5309.4 2552.8 5993.1 True False 6102.949596076142 6580.046127380258 6260.8231117392925 6566.881563248206 6325.284792881389 6534.1049627744915 5524.023568741435 5168.577464638227 4331.915150864927 6762.3727627375 0.902486421586376 0.9730380678861847 0.925832297538834 0.9710913304622153 0.9353647033087877 0.9662444221914495 0.8168765258224593 0.7643141905927583 0.6405910030181935 1.0 12.723313828862976 -7.367436447592156 3.928428940345955 0.7789992134073109 0.9467500176029618 0.3850525474016263 0.08526709157813296 0.21157150221349688 5.788017408184708 0.03577516512451313 0.02330010144973585 4.291049776473449e-08 7.367436447592156 0.16775080419565092 THSDAS(ph)DDEAFTTSK ddPTM_A459_Selumetinib_30min_R1 2 THSDASDDEAFTTSK 15 0 Q13017-2;Q13017;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 THS(0.001)DAS(0.999)DDEAFTTSK;THSDAS(1)DDEAFTTSK 263.15 1.1968e-36 15051600.0 1765.77 2282.95 2261.54 2368.5 1932.79 1544.15 1727.49 1501.38 1050.87 1523.48 True False 1806.9090054096862 2015.661152685338 1954.4352897500041 1954.8859372514078 1757.9694857617908 1528.617252976022 1597.1840384898223 1461.5585252304488 1783.2496374919408 1719.0334979518664 1.0511191361672234 1.1725549008130949 1.136938455288164 1.1372006069576577 1.0226499296589127 0.8892306373303867 0.9291174607084615 0.8502210846803249 1.0373559558999779 1.0 10.747381942833599 -6.47755299544252 3.3052743820250132 0.9315386584110762 1.1281240364593388 0.6911142567963842 0.05734879157565392 0.1282926191611679 2.8238010827312374 0.018457981903001613 0.020222739376467933 3.3300212474028277e-07 6.47755299544252 0.1965853780482626 THSDAS(ph)DDEAFTTSK ddPTM_A459_Selumetinib_30min_R2 1 THSDASDDEAFTTSK 15 0 Q13017-2;Q13017;H0YK04 Q13017-2 ARHGAP5 Rho GTPase-activating protein 5 1 THSDAS(1)DDEAFTTSK 125.67 0.0012092 7620900.0 25382.0 18290.0 28630.0 23044.0 23519.0 17500.0 19157.0 19912.0 15752.0 16827.0 True False 23971.370052196504 19692.784188380734 26787.976969987074 19905.367446882727 20564.332957472303 19910.466150816832 20047.838458875354 19969.94062339094 18902.840147653515 16341.160788203475 1.4669319005477996 1.2051031406897827 1.6392946203261798 1.218112207870338 1.2584377097811494 1.2184242238892848 1.2268307446890612 1.2220637739399178 1.1567623862620147 1.0 13.996222847972074 -6.738258756888739 0.14560205896872733 0.8697783153879651 1.6781040519776298 0.5204055397915821 0.11462691750125652 8.972714084375472 0.5707541326938967 0.9498858001856139 1.9830422018885248 1.8270113406149e-07 6.738258756888739 0.8083257365896647 THSLCNGDS(ph)PGPVQK ddPTM_A459_Selumetinib_30min_R2 2 THSLCNGDSPGPVQK 15 0 Q674X7-3;A0A1B0GWK2;Q674X7-4;Q674X7-2;Q674X7 Q674X7-3 KAZN Kazrin 1 THS(0.004)LCNGDS(0.995)PGPVQK;THSLCNGDS(1)PGPVQK 213.71 4.794600000000001e-07 12387400.0 88343.0 72388.0 91348.0 76971.0 96478.0 56214.0 56798.9 73089.0 48147.8 70998.0 True False 83433.24972504909 77939.92683589416 85470.76913218222 66487.41701761895 84357.57111573663 63956.96824011522 59440.1613948852 73301.67688946475 57778.70536193449 68948.10326504243 1.210087671365295 1.1304143717527135 1.239639164599282 0.9643110378545964 1.2234937165923025 0.9276102635377675 0.8621000227720858 1.0631427612691071 0.8380028256880132 1.0 16.07322324386658 -6.773005244421199 24.998125598051097 0.9373630986962492 1.1465668019601578 0.5696082962032984 0.09352498279732699 163.3896292789845 353143.42135166033 0.03131310407601013 0.027844729384997952 1.6865326591593649e-07 6.773005244421199 0.20920370326390858 THSTSS(ph)SLGSGESPFSR ddPTM_A459_Selumetinib_30min_R1 2 THSTSSSLGSGESPFSR 17 0 F8WBF9;Q5TH30;Q9UGV2-3;Q9UGV2-2;Q9UGV2 F8WBF9 NDRG3 Protein NDRG3 1 T(0.001)HSTS(0.013)S(0.676)S(0.309)LGSGESPFSR;T(0.002)HS(0.001)T(0.001)S(0.006)S(0.677)S(0.308)LGS(0.006)GESPFSR 88.471 0.006655500000000001 110117000.0 3523.5 3325.1000000000004 3609.1000000000004 4220.799999999999 5251.3 3225.5 4547.5 2924.6000000000004 1242.6100000000001 2594.7 True False 3605.5906944624885 2935.7957462029494 3119.0040433672375 3483.7165142287267 4776.320842192315 3193.054398519679 4204.478413786747 2847.0301075603566 2108.6184133564198 2927.755019518279 1.2315206260173155 1.0027463796086304 1.0653227550030555 1.1898934477113197 1.6313936139978649 1.0906152930257982 1.4360758962949487 0.9724277094839703 0.7202168211817679 1.0 11.515579125540725 -7.953976118407785 7.459915819331325 0.8551105883844619 1.2271070358162137 0.4191069762546402 0.18518986767319742 0.2005661285570673 26.955728664585443 0.10581477795953516 0.050125074827350055 1.1117928624211463e-08 7.953976118407785 0.37199644743175186 THSTSSS(ph)LGSGESPFSR ddPTM_A459_Selumetinib_30min_R2 2 THSTSSSLGSGESPFSR 17 0 F8WBF9;Q5TH30;Q9UGV2-3;Q9UGV2-2;Q9UGV2 F8WBF9 NDRG3 Protein NDRG3 1 T(0.002)HS(0.002)T(0.002)S(0.005)S(0.078)S(0.911)LGS(0.001)GESPFSR;THSTS(0.002)S(0.23)S(0.758)LGS(0.01)GESPFSR 151.11 0.00042421 3117400.0 28727.6 25259.8 32355.8 43779.0 40807.0 25646.1 25273.5 26939.3 21518.3 28708.5 True False 27131.034997694445 27197.14543694147 30274.063054331386 37816.224677012644 35680.45984079137 29178.617482883627 26448.76782849019 27017.688902958816 25822.56127153712 27879.611011359102 0.973149696623828 0.9755209793228617 1.0858854179133526 1.3564114887257583 1.2798047944877688 1.0465934216584034 0.9486777924453128 0.9690841415237426 0.9262166986840717 1.0 14.76692281177809 -6.998263681497533 24.944113223649655 0.9640207867333411 1.137826671491139 0.34396173392829044 0.11273036202215433 73.20055991510146 1051585.7782501788 0.04613983731087798 0.04040458569316677 1.0040060238483281e-07 6.998263681497533 0.1738058847577978 THTDSS(ph)EKELEPEAAEEALENGPK ddPTM_A459_Selumetinib_30min_R2 1 THTDSSEKELEPEAAEEALENGPK 24 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 T(0.205)HT(0.205)DS(0.205)S(0.384)EKELEPEAAEEALENGPK 64.422 0.0013301 2930200.0 33026.0 26056.0 22257.0 23028.0 23034.0 17374.0 22863.0 22133.0 13249.0 27998.0 True False 31190.54713355297 28054.411416754985 20825.00885158932 19891.54667448427 20140.262993427303 19767.110794530938 23926.174802175046 22197.403365684615 15899.170207990204 27189.62499245978 1.147148853366044 1.0318057503380436 0.7659174724684326 0.7315859148480566 0.7407333863196934 0.7270093206512686 0.8799744317477806 0.8163924059945804 0.5847513605796093 1.0 14.730768632962526 -5.143389065260181 3.104503275314872 0.7716297984409067 1.1318861571993615 0.5958539920554582 0.10326086380620486 0.16542287858108073 2.9358150185973564 0.02611173202903213 0.09249103560944384 7.188047440282959e-06 5.143389065260181 0.36025635875845474 THYDPPR ddPTM_A459_Selumetinib_30min_R2 1 THYDPPR 7 0 P31943;G8JLB6;E9PCY7;H0YB39;D6RBM0;H0YBD7;E5RGV0;E7EN40;P55795 P31943;P55795 HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 0 95.352 0.033503 5668300.0 40508.0 29423.0 32697.0 37576.0 37458.0 30645.0 25013.0 28893.0 27451.0 33178.0 False True 38256.72752637208 31679.64949014361 30593.31061780188 32458.083977784452 32752.19116123122 34866.07058238752 26176.154062319205 28977.073846506348 32941.96704502518 32220.064933203455 1.1873572448002025 0.9832273633159896 0.9495111409994345 1.0073872925170835 1.016515367958784 1.0821229148566147 0.8124177935887438 0.899348710394586 1.0224053586893238 1.0 14.97567178106495 -7.238718819563972 24.95361198815243 0.9251553288086041 1.0288638682536382 0.27884297780152334 0.08086098672429069 1059.8070561812453 1163969.8896939314 0.031221570060088653 0.024165522246700627 5.771400070667452e-08 7.238718819563972 0.10370853944503411 TIAATPIQTLPQSQS(ph)TPK ddPTM_A459_Selumetinib_30min_R2 2 TIAATPIQTLPQSQSTPK 18 0 A0A0C4DG88;P14859-4;P14859-5;P14859-3;P14859;P14859-2;P14859-6 A0A0C4DG88 POU2F1 POU domain protein;POU domain, class 2, transcription factor 1 1 TIAATPIQTLPQS(0.002)QS(0.68)T(0.318)PK;TIAATPIQTLPQS(0.003)QS(0.526)T(0.471)PK 174.59 1.5498e-08 11702300.0 98350.0 92798.0 89632.0 92627.0 90346.0 72986.0 90424.0 93165.0 66639.0 98264.0 True False 92884.10072624397 99915.30820740073 83865.17470394266 80011.04280951245 78995.92777651225 83039.1589990581 94628.89517175683 93436.094725704 79968.66204923062 95426.86299946682 0.9733538105173063 1.0470354475338772 0.8788424146816106 0.8384540819492253 0.8278164585265014 0.8701864065207935 0.9916379119817189 0.9791382823327857 0.8380099642348867 1.0 16.54210782671054 -10.359445328008745 21.410409406248156 0.9999999685009087 0.9166625423634311 0.1058959304609276 0.07315895681467403 0.0 0.0 0.07760902482796186 0.01882295334511002 4.370736974656133e-11 10.359445328008745 -0.08333742613747752 TIAHS(ph)PTSFTESSSK ddPTM_A459_Selumetinib_30min_R1 2 TIAHSPTSFTESSSK 15 0 Q03164-2;Q03164;Q03164-3 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 TIAHS(0.998)PT(0.002)S(0.001)FTESSSK;TIAHS(0.892)PT(0.088)S(0.016)FT(0.004)ESSSK 183.76 2.0957e-05 14310900.0 3816.23 6821.700000000001 5465.5 5642.6 5886.5 4139.1 4959.5 3527.7700000000004 1515.2800000000002 3066.2 True False 3905.1407339090642 6023.012192677712 4723.315119842516 4657.225834720199 5354.067114345984 4097.4644120021085 4585.400922083644 3434.2020797880723 2571.3194883275637 3459.776637317204 1.128726257004038 1.7408673518727797 1.3652081087827366 1.3461059261708659 1.5475181422398585 1.1843147236173557 1.325345940725028 0.9926080321910715 0.7432038995215102 1.0 11.756463185345883 -7.715377437280724 1.6147681910979623 0.854113794834101 1.4141254297358317 0.6039663840284104 0.17356679838471106 0.24766480144772907 1.2317464328275884 0.12524714658386327 0.051139714190200386 1.9258504647540798e-08 7.715377437280724 0.5600116349017307 TIAHS(ph)PTSFTESSSK ddPTM_A459_Selumetinib_30min_R2 5 TIAHSPTSFTESSSK 15 0 Q03164-2;Q03164;Q03164-3 Q03164-2 KMT2A Histone-lysine N-methyltransferase 2A;MLL cleavage product N320;MLL cleavage product C180 1 T(0.074)IAHS(0.906)PT(0.018)S(0.002)FTESSSK;T(0.028)IAHS(0.956)PT(0.012)S(0.003)FTESSSK;TIAHS(0.859)PT(0.107)S(0.028)FT(0.005)ESSSK;T(0.012)IAHS(0.985)PT(0.003)S(0.001)FTESSSK;T(0.017)IAHS(0.93)PT(0.053)SFTESSSK 174.21 2.709e-05 45213100.0 201386.0 218742.0 294269.0 245759.0 307228.0 192230.0 145264.6 199280.0 181907.0 309356.0 True False 190193.77233203247 235518.80803361302 275336.0529158619 212286.20024207872 268631.271986832 218707.93760980075 152019.69173634416 199859.87180741993 218293.4829062471 300424.0884765842 0.6330842952590223 0.7839544732511353 0.9164912651048029 0.7066217669779993 0.8941735443020903 0.7279973410882044 0.5060169858789235 0.6652591435689669 0.726617775602443 1.0 18.196640969487483 -6.993087597232501 24.913234783523997 0.685211081782252 0.7916107294868103 0.01663031444927221 0.13850697913493237 364.7666633268545 1314659.1830336382 0.047198166645787444 0.04153416791969479 1.0160437360968652e-07 6.993087597232501 0.10639964770455834 TIAPALVS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 T(0.03)IAPALVS(0.97)K 89.301 0.030051 30719000.0 3147.4 8886.3 6182.6 8098.8 5707.8 5790.3 6191.9 6315.1 1847.7 4355.3 True False 3220.7282962256954 7845.8878648712125 5343.03687859086 6684.4966133044945 5191.530497793936 5732.054839171751 5724.839997872709 6147.603033664232 3135.411949331373 4914.3451792145415 0.655372827665407 1.596527630589681 1.0872327204831869 1.3602008750986587 1.0564033067420178 1.1663923941313181 1.16492427558532 1.250950596564892 0.6380121531944374 1.0 12.262783479531782 -8.250272089195875 24.738289920953964 0.8190060671383249 1.1815231780577535 0.25027660945565444 0.24007843846617655 682.8949242084277 1512789.3241770943 0.1509801124883954 0.05587412811762523 5.619891238954559e-09 8.250272089195875 0.3625171109194286 TIAPALVSK ddPTM_A459_Selumetinib_30min_R2 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 134.05 0.041213 18846000.0 166960.0 168120.0 193670.0 181330.0 204910.0 172530.0 153320.0 131290.0 144490.0 180100.0 False True 157681.03159383536 181014.26340899733 181209.4830519528 156632.54118830268 179167.37388135772 196294.44142859578 160449.68379781654 131672.03216377037 173392.0373879167 174900.04504400314 0.901549405285541 1.0349583578635209 1.036074536209309 0.895554607483923 1.0243986720316793 1.122323561318752 0.9173793166116623 0.7528416137951421 0.9913778886923269 1.0 17.41617113525013 -7.50270560142195 24.806790159200823 0.8902879465497008 1.0031361097921119 0.17054169403903086 0.08932882188601715 943.3401400912983 1160024.3295180001 0.037041069681173294 0.024599397308737166 3.142638296652599e-08 7.50270560142195 0.11284816324241109 TIAQDYGVLK ddPTM_A459_Selumetinib_30min_R1 1 TIAQDYGVLK 10 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 155.15 0.0073436 22044000.0 1960.9 2198.8 2153.5 2399.0 2037.1 2188.9 2292.3 2193.8 1761.2 2023.4 False True 2006.5851547528011 1941.3634738056137 1861.066528328764 1980.0596848073155 1852.844664679215 2166.8816533621825 2119.3899654586826 2135.6132975333076 2988.6277670414074 2283.1230995850333 0.8788773391664716 0.8503104690931752 0.8151406854352358 0.8672592753177432 0.8115395376692465 0.9490866496668628 0.9282854550610478 0.9353912182490133 1.3090085977337806 1.0 11.156792932386358 -8.087483900364028 5.617123430958846 1.1527128248086156 0.8728593170143485 0.657829860177785 0.08038969474080608 0.128495448868321 6.342457130864029 0.05386415681099906 0.01986836608958736 8.175533447235447e-09 8.087483900364028 -0.2798535077942671 TIAQDYGVLK ddPTM_A459_Selumetinib_30min_R2 2 TIAQDYGVLK 10 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 ; 155.15 0.0073436 29656000.0 113635.0 106448.0 114309.0 122728.0 127420.0 92052.0 86707.0 105071.0 82924.0 103864.0 False True 107319.62161694694 114612.21931573299 106954.48339022888 106012.2346823913 111412.36045074697 104731.32743514219 90739.04730666113 105376.73921455967 99511.11709014847 100865.1764489195 1.0639908181918079 1.136291268709328 1.0603707558514324 1.0510290906602278 1.1045671496660576 1.0383298886923635 0.8996072827237209 1.0447286459457583 0.9865755515784305 1.0 16.6220686465416 -7.0056643544929145 16.843500705050445 0.983956856598986 1.0819678754474067 0.579538813265037 0.04034956992019836 2.606376436361025 7750.4745412699895 0.014313470097247923 0.012103768960079154 9.870420286693348e-08 7.0056643544929145 0.09801101884842067 TICTFDSSGFES(ph)MSPIKETVSSR ddPTM_A459_Selumetinib_30min_R1 1 TICTFDSSGFESMSPIKETVSSR 23 1 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 TICTFDS(0.005)S(0.004)GFES(0.702)MS(0.288)PIKETVSSR 88.036 0.0004108000000000001 20014000.0 1492.0 2296.4 2041.2 2360.3 2202.4 1411.4 2004.1 1633.0 892.96 1293.1 True False 1526.760697073373 2027.5364204326045 1764.016251509019 1948.1179133183443 2003.1933088653013 1397.2025974486658 1852.9291234898337 1589.6875352684347 1515.287900782022 1459.0819808606336 1.0463844507029134 1.3895973269690236 1.2089904985794706 1.3351668644206371 1.372913472403878 0.9575901942292039 1.269928042286487 1.0895121426492869 1.0385214269373921 1.0 10.510845230329359 -6.754710384987564 24.999951654394255 1.0891309717615585 1.2773840245766772 0.40477514719304575 0.11982966541796516 169.2931758196961 628967.4057226873 0.038607298592328324 0.03777785141565242 1.759096299510402e-07 6.754710384987564 0.18825305281511873 TICTFDSSGFESMS(ph)PIKETVSSR ddPTM_A459_Selumetinib_30min_R1 3 TICTFDSSGFESMSPIKETVSSR 23 1 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 TICTFDS(0.003)S(0.003)GFES(0.058)MS(0.935)PIKETVSSR;TICTFDSSGFES(0.073)MS(0.925)PIKET(0.001)VSSR;TICTFDS(0.001)S(0.001)GFES(0.007)MS(0.97)PIKET(0.02)VS(0.001)SR 110.89 8.345900000000001e-06 347639000.0 6009.9 7770.599999999999 8456.4 8825.4 7211.8 6827.1 7051.6 6564.7 3764.2000000000003 6116.5 True False 6149.918976770287 6860.81453954607 7308.067327680227 7284.209563275731 6559.493963346706 6758.4255725108305 6519.692134724271 6390.582830849168 6387.572473709556 6901.612354755292 0.8910843815406296 0.9940886544893945 1.058892756073859 1.0554359168342489 0.9504292078686711 0.9792531404424933 0.9446621745181222 0.9259550525821668 0.9255188708633344 1.0 12.752717728360498 -6.335163683458483 24.9440226403643 0.9513661821498959 1.0036778271086455 0.17488662251870168 0.047957677005971866 225.19904842989735 76192.95588907492 0.015766457055999987 0.017877482446941383 4.622067850983703e-07 6.335163683458483 0.052311644958749626 TICTFDSSGFESMS(ph)PIKETVSSR ddPTM_A459_Selumetinib_30min_R2 6 TICTFDSSGFESMSPIKETVSSR 23 1 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 TICTFDS(0.001)S(0.001)GFES(0.019)MS(0.976)PIKET(0.002)VSSR;TICT(0.003)FDS(0.008)S(0.003)GFES(0.203)MS(0.78)PIKET(0.003)VSSR;T(0.002)ICT(0.01)FDS(0.027)S(0.012)GFES(0.209)MS(0.734)PIKET(0.005)VSSR;TICT(0.002)FDS(0.007)S(0.007)GFES(0.133)MS(0.846)PIKET(0.004)VS(0.001)SR;TICT(0.001)FDS(0.028)S(0.028)GFES(0.136)MS(0.68)PIKET(0.002)VS(0.029)S(0.096)R;TICT(0.001)FDS(0.003)S(0.003)GFES(0.318)MS(0.67)PIKET(0.004)VSSR 81.904 0.00025504 57723400.0 167486.1 166944.40000000002 203117.7 217270.0 233858.0 187018.2 155728.9 167764.3 162534.6 201880.3 True False 158177.89306198034 179748.4986691475 190049.3283198303 187677.4511883447 204478.667322954 212778.2594678111 162970.6024209614 168252.46633812497 195046.06159616561 196051.49119098813 0.80681810733022 0.9168433128317361 0.9693847629788712 0.9572865273721093 1.0429845041257877 1.0853182405051343 0.8312642838416352 0.8582054914043877 0.9948716044508784 1.0 17.580873089643326 -4.773940372976221 2.2410955980933087 0.9640751770378557 0.764230500415564 0.3128338502970498 0.07221296818770584 0.9041390288944082 5.252305225659305 0.02090637973307812 0.3672800596814576 1.6829051018467426e-05 4.773940372976221 -0.19984467662229177 TIDFDSLS(ph)VGR ddPTM_A459_Selumetinib_30min_R1 2 TIDFDSLSVGR 11 0 A0A1C7CYX9 A0A1C7CYX9 1 TIDFDSLS(1)VGR;TIDFDSLS(1)VGR 136.53 0.0014078 11311500.0 7641.3 10219.9 9148.0 10738.8 8508.8 9743.8 9886.1 9029.1 4932.4 6487.200000000001 True False 7819.327422618477 9023.349356897394 7905.751846367089 8863.470172242096 7739.180542350648 9645.786218662544 9140.38351765523 8789.6189373498 8369.922551757354 7319.895310679068 1.0682294063974909 1.232715629652946 1.0800361905221936 1.210873898607688 1.0572802224452418 1.3177492039524406 1.2487041316451934 1.2007847877997022 1.1434483959827118 1.0 12.837607299859357 -4.739692630227324 24.41164573420267 1.1746939250503774 1.068228858524361 0.08389424084408714 0.09248723456539172 3065.942468944351 3441411.2417354886 0.022128898011603355 1.0297780609663456 1.8209891987515607e-05 4.739692630227324 -0.1064650665260165 TIDLGAAAHYT(ph)GDKASPDQNASTHTPQSSVK ddPTM_A459_Selumetinib_30min_R2 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 1 T(0.006)IDLGAAAHY(0.378)T(0.425)GDKAS(0.137)PDQNAS(0.025)T(0.025)HT(0.001)PQSSVK 40.414 0.039359 8915700.0 35910.0 32599.0 38387.0 50588.0 42396.0 35263.0 33983.0 34953.0 31249.0 43779.0 True False 33914.265959119715 35099.23847769402 35917.22221260544 43697.82713083246 37069.83545495111 40120.15816435733 35563.27683603701 35054.70744321934 37499.67317001172 42514.986518497666 0.7977014398055636 0.8255733178328268 0.84481320950151 1.0278217332097743 0.8719239611853706 0.943670960518866 0.83648801865582 0.8245258981316514 0.8820342246538441 1.0 15.375683859970978 TIDLGAAAHYTGDKAS(ph)PDQNASTHTPQSSVK ddPTM_A459_Selumetinib_30min_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 1 TIDLGAAAHY(0.032)T(0.197)GDKAS(0.771)PDQNASTHTPQSSVK 129.62 1.8577e-18 61702000.0 4543.8 4665.6 4357.7 5018.8 6263.2 4868.0 5959.3 4256.1 861.72 2441.5 True False 4649.661699304287 4119.349383021405 3765.948275132693 4142.360794543957 5696.694665857773 4819.0323397903585 5509.7852031400425 4143.214402238815 1462.275902461347 2754.890307223911 1.6877846958595342 1.4952861724547037 1.3670048006113247 1.5036391044978459 2.067848092143568 1.7492646901961308 2.0000016656533326 1.5039489562885395 0.5307927864230918 1.0 11.427779160128333 -8.147584706117017 5.003741671730946 0.7769182426009211 1.6878533153247837 0.7131175500494238 0.23199317877469988 0.1225900992978965 4.43061231436348 0.17808758720700013 0.06373026468606514 7.118939364982721e-09 8.147584706117017 0.9109350727238625 TIDLGAAAHYTGDKASPDQNAST(ph)HTPQSSVK ddPTM_A459_Selumetinib_30min_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677-2;Q14677;Q14677-3 Q14677-2 CLINT1 Clathrin interactor 1 1 TIDLGAAAHY(0.063)T(0.221)GDKAS(0.221)PDQNAS(0.208)T(0.256)HT(0.028)PQS(0.001)S(0.001)VK 50.865 0.0075514 44256000.0 2450.2 2295.6 2197.1 2572.6 3558.1 2203.1 2903.0 2182.0 345.54 1282.9 True False 2507.284892740737 2026.8300848045133 1898.7458878064203 2123.3437036829096 3236.2704832335758 2180.938814254753 2684.02437278129 2124.1262718651087 586.3561427569202 1447.5727115042207 1.7320614521223838 1.4001577044778408 1.3116756572686221 1.4668304305601843 2.235653143717154 1.5066178002129285 1.854155132554434 1.4673710377269125 0.40506161666146506 1.0 10.499420101195726 -8.145106290499461 5.3021080892439 0.7146535511441652 1.6334158560889438 0.6295135955198117 0.2840962341859778 0.14130998467834927 5.444866759929942 0.20502094185659944 0.07415248098506468 7.1596816063026625e-09 8.145106290499461 0.9187623049447786 TIEAAEALLHMES(ph)PTCLR ddPTM_A459_Selumetinib_30min_R1 2 TIEAAEALLHMESPTCLR 18 0 Q15723-2;Q15723-3;Q15723-1;Q15723;Q15723-4;D6RHI1 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 TIEAAEALLHMES(0.613)PT(0.387)CLR;TIEAAEALLHMES(0.851)PT(0.149)CLR 101.3 0.001704 2156100.0 1347.1 1379.78 1598.18 1508.9 1611.67 1666.29 1734.6999999999998 1499.48 960.8199999999999 1452.04 True False 1378.4848089996933 1218.23471615768 1381.1559341743514 1245.398940560967 1465.8947330634483 1649.5286354702705 1603.850182385018 1459.7089194025189 1630.441364483719 1638.423478067338 0.8413483006394263 0.7435408076516903 0.8429786027013871 0.7601202968783276 0.8946983198706342 1.006777953045468 0.9788984373422783 0.8909228529393216 0.9951281743148392 1.0 10.678092578604234 -6.4840956537831484 4.089804018054663 0.967260912774298 0.7975032489497069 0.7947678604777239 0.04233203759405275 0.09716079223178122 3.522309879807365 0.013455575507334451 0.014712910326671123 3.280230377623113e-07 6.4840956537831484 -0.16975766382459112 TIEAAEALLHMES(ph)PTCLR ddPTM_A459_Selumetinib_30min_R2 1 TIEAAEALLHMESPTCLR 18 0 Q15723-2;Q15723-3;Q15723-1;Q15723;Q15723-4;D6RHI1 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 TIEAAEALLHMES(0.758)PT(0.242)CLR 74.33800000000002 0.010818 595070.0 3721.4 4346.8 5233.3 5710.8 5202.5 3941.8 3886.0 2878.9 3509.1 4427.9 True False 3514.5794859445296 4680.185582835066 4896.595175586217 4932.979188320513 4548.915439059891 4484.747169902269 4066.706699962919 2887.2771223724476 4211.018052446101 4300.055021934162 0.8173336080624554 1.0884013248579134 1.1387284931493113 1.147189783190649 1.057873775069462 1.0429511127243745 0.945733642760161 0.6714512041461628 0.9792939929759289 1.0 12.070139404793961 -7.39373955989956 3.769690677730471 0.8603954418827665 1.0595393804720996 0.2673985779270509 0.1202474314254404 0.2687959690708382 6.7517536761493915 0.05375974528992056 0.03450667248786309 4.038875258485719e-08 7.39373955989956 0.1991439385893331 TIEGS(ph)SPADNR ddPTM_A459_Selumetinib_30min_R2 1 TIEGSSPADNR 11 0 Q9Y217 Q9Y217 MTMR6 Myotubularin-related protein 6 1 TIEGS(0.5)S(0.5)PADNR 127.52 0.0029518 5593400.0 39206.0 27690.0 29720.0 35561.0 39935.0 31743.0 37090.0 30878.0 28449.0 32363.0 True False 37027.08747405312 29813.733962616883 27807.847556689358 30717.530453853367 34918.00827657026 36115.31011573591 38814.75849244072 30967.849867871933 34139.59493147504 31428.596100827788 1.178133676581178 0.9486180632112813 0.8847944549440735 0.9773752017209674 1.111026663887496 1.1491226015909977 1.2350140734227193 0.9853399040963297 1.0862589859868366 1.0 14.939790208682304 -6.2616860848268185 24.84889509839547 1.103488076819827 0.9857270344596907 0.18888427716069334 0.09646687195659065 30.626814475016563 3084792.987318459 0.03011269312560975 0.036368819481775436 5.474114979344317e-07 6.2616860848268185 -0.11776104236013629 TIET(ph)SPSLSR ddPTM_A459_Selumetinib_30min_R1 2 TIETSPSLSR 10 0 H3BP78;F8W7R3;Q9NVI1-2;Q9NVI1-1;Q9NVI1 H3BP78 FANCI Fanconi anemia group I protein 1 T(0.135)IET(0.404)S(0.404)PS(0.057)LSR;TIET(0.496)S(0.496)PS(0.008)LSR 125.23 0.0085635 53484000.0 8973.5 12185.2 12469.6 14110.5 11064.6 10194.5 10094.8 9698.1 5321.1 7814.7 True False 9182.565090608528 10758.551119254205 10776.296810609878 11646.366061889794 10063.808883613789 10091.9525858654 9333.341108629898 9440.874884131543 9029.518062232595 8817.792866624082 1.0413677469523164 1.2200956953724802 1.2221081821278497 1.3207801813957374 1.1413070181888665 1.1444987128314268 1.058466812478347 1.070661902239263 1.024011132809652 1.0 13.106201872547475 -7.1444240471716585 1.4616247684998784 1.0320244046430311 1.2023097484691971 0.5343064883316122 0.067432403173703 0.3379649548807266 1.4306762548614371 0.038584417632035725 0.025224914596104864 7.17093775603516e-08 7.1444240471716585 0.170285343826166 TIET(ph)SPSLSR ddPTM_A459_Selumetinib_30min_R2 2 TIETSPSLSR 10 0 H3BP78;F8W7R3;Q9NVI1-2;Q9NVI1-1;Q9NVI1 H3BP78 FANCI Fanconi anemia group I protein 1 T(0.006)IET(0.494)S(0.494)PS(0.005)LSR;TIET(0.498)S(0.498)PS(0.005)LSR 152.64 0.0014641 52350000.0 333940.0 323170.0 366160.0 432590.0 453680.0 332690.0 329010.0 325120.0 326410.0 404770.0 True False 315380.95166773675 347956.0998446699 342601.66424486396 373670.49574062723 396684.66244934016 378515.0276408715 344309.6169209465 326066.04537348676 391701.1206574132 393083.2383812399 0.8023261255466152 0.8851969910434022 0.8715753580736115 0.9506141683360592 1.0091619883944463 0.9629386111695786 0.8759203733510782 0.8295089017691588 0.996483905725621 1.0 18.58447532097717 -4.956859921575201 1.2497390304866887 0.9373380865434628 0.7771867786644286 0.3754547029288898 0.056154014233814914 1.3442444132269251 2.270330481704931 0.01842933588183954 0.25698293505907405 1.1044347896092205e-05 4.956859921575201 -0.1601513078790342 TIFPHTAGS(ph)NK ddPTM_A459_Selumetinib_30min_R2 1 TIFPHTAGSNK 11 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 TIFPHT(0.005)AGS(0.995)NK 92.65 0.016345 5382900.0 46823.0 38606.0 46632.0 46576.0 49143.0 32869.0 37542.0 44894.0 32870.0 40905.0 True False 44220.76510732005 41566.9560621447 43631.747889082704 40232.26845191848 42969.216996005816 37396.406394925616 39287.77738806175 45024.634107398226 39444.91846453602 39723.96636604641 1.1132011516633753 1.0463949062668014 1.0983733972339789 1.0127958543008568 1.0816950301501929 0.9414066573898259 0.9890195008734707 1.1334375246547006 0.9929753263070704 1.0 15.277722060092914 -5.817702755598746 1.6231144106258972 1.0226716437755552 1.0850408120750918 0.21343277326571097 0.05331521685010373 0.6927242928790582 3.7161380667134045 0.017608355950490828 0.036037802390192004 1.5215885951078823e-06 5.817702755598746 0.06236916829953665 TIFQGIAAK ddPTM_A459_Selumetinib_30min_R2 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 155.07 0.011458 5537700.0 41773.0 34519.0 41228.0 42882.0 51927.0 30584.0 33647.0 35892.0 27882.0 39156.0 False True 39451.42389056829 37166.496303920954 38575.43536565239 37041.397624423924 45403.46602673004 34796.668386090394 35211.65217026563 35996.43977775953 33459.17908817138 38025.46454049416 1.0375001164957653 0.9774107102450129 1.0144632243630463 0.974120844335188 1.1940279119635444 0.9150885809438212 0.9260018936196811 0.9466403688356291 0.879915064615186 1.0 15.214678252382154 TIGGGDDS(ph)FNTFFSETGAGK ddPTM_A459_Selumetinib_30min_R1 3 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 TIGGGDDS(0.998)FNT(0.002)FFSETGAGK;T(0.014)IGGGDDS(0.937)FNT(0.05)FFSETGAGK;T(0.026)IGGGDDS(0.974)FNTFFSETGAGK 321.17 2.088999999999999e-135 96791000.0 8237.82 9899.9 9929.090000000002 10560.689999999999 9110.63 8204.019999999999 8180.4 8286.099999999999 4759.509999999999 6766.78 True False 8429.745177992614 8740.815105661351 8580.774114587348 8716.46374020332 8286.575125112367 8121.495007454163 7563.345841922173 8066.325710953929 8076.540849143345 7635.362127018882 1.1040399967622605 1.1447806875761213 1.1238201897750184 1.1415914000147809 1.0852890782729308 1.063668608292333 0.9905680589998648 1.05644310993581 1.057780982065446 1.0 12.898480866892479 -6.669559476480523 2.0566701610501332 1.0311551120832911 1.1291113654300347 0.7843905955826443 0.023734431878712502 0.1451689098670888 1.2594151909661626 0.009043991435788174 0.008848121481390093 2.140131816382282e-07 6.669559476480523 0.09795625334674352 TIGGGDDS(ph)FNTFFSETGAGK ddPTM_A459_Selumetinib_30min_R2 2 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 TIGGGDDS(0.986)FNT(0.014)FFS(0.001)ETGAGK;TIGGGDDS(0.962)FNT(0.035)FFS(0.002)ETGAGK 227.36 8.964499999999997e-24 27661000.0 154325.0 145988.0 170218.0 195412.0 199024.0 161158.0 162678.0 167824.0 132618.0 189730.0 True False 145748.23431192295 157184.8101745939 159266.35919934564 168796.54849549793 174020.8258228651 183356.05165333356 170242.84934034175 168312.3400552413 159145.30565652062 184252.0019222589 0.7910265983075626 0.8530968919453835 0.8643941858853973 0.9161178534533261 0.9444718320959649 0.9951373648070138 0.923967433537965 0.913489885044815 0.8637371860071756 1.0 17.491320768913873 -5.376686038540821 1.2336813209126611 0.9376383659026947 0.7955771397145405 0.6156215839964732 0.03835618513744843 0.47134874452198133 1.15653812070466 0.013029645793514113 0.0653114323613 4.200625471179421e-06 5.376686038540821 -0.1420612261881542 TIGGGDDS(ph)FTTFFCETGAGK ddPTM_A459_Selumetinib_30min_R1 1 TIGGGDDSFTTFFCETGAGK 20 0 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 1 T(0.073)IGGGDDS(0.876)FT(0.049)T(0.003)FFCETGAGK 70.345 0.0073179 3961800.0 2194.6 2773.1 2819.2 3398.0 2968.9 2807.2 2675.9 2273.5 1891.2 2214.0 True False 2245.7299100517603 2448.424162820785 2436.3681247571167 2804.6030883598396 2700.363519201867 2778.9621167336654 2474.0547086205493 2213.199394631223 3209.2282722170744 2498.1884661862528 0.8989433505311563 0.9800798442395189 0.9752539320928372 1.1226547261429642 1.0809286632102084 1.1123909001853824 0.9903394968424676 0.8859217087051501 1.2846221634816442 1.0 11.28666660427242 -5.602066957971168 6.070657492610785 1.0623399087010714 0.9484618599898178 0.22552363902010542 0.09979820232432896 0.32309541568852224 19.130456911090164 0.026822001966940553 0.04709340140398421 2.4999598970996686e-06 5.602066957971168 -0.11387804871125362 TIGGGDDSFNT(ph)FFSETGAGK ddPTM_A459_Selumetinib_30min_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 TIGGGDDS(0.251)FNT(0.749)FFSETGAGK 337.02 9.726999999999994e-156 17647000.0 4042.9 4279.4 5260.5 4840.3 4143.2 3609.2 3887.1 3691.5 1960.1 2936.3 True False 4137.091703886022 3778.3658585609146 4546.152993858124 3995.0324686839704 3768.4482915413696 3572.8947248914014 3593.8929174778355 3593.589428318082 3326.1465399601775 3313.202706984054 1.2486684545938749 1.1403968283003998 1.3721324639374093 1.2057917435183352 1.1374034808065567 1.0783809627343146 1.0847186952679053 1.0846270953307466 1.0039067434506312 1.0 11.694010757146623 -6.490148446864576 1.7749902598155232 1.0531127399683482 1.2468667976468395 0.7006445935257408 0.05940292550106362 0.21124218356371616 1.3395170377783645 0.022661820592948852 0.025318519898722018 3.2348306778563554e-07 6.490148446864576 0.1937540576784913 TIGGGDDSFNTFFS(ph)ETGAGK ddPTM_A459_Selumetinib_30min_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 TIGGGDDSFNT(0.001)FFS(0.998)ET(0.001)GAGK 259.55 1.5122999999999996e-47 9906800.0 4089.7 4755.0 4941.4 5120.3 4223.2 4689.1 4310.2 4588.2 2556.0 4107.3 True False 4184.98205282907 4198.282389460472 4270.38502116729 4226.135724934931 3841.2123056665187 4641.9319113621505 3985.0781438380704 4466.506031425983 4337.345317146176 4634.511963489974 0.9030038299173168 0.9058736761354687 0.9214314376160372 0.9118836585659563 0.828827789404158 1.0016010203297845 0.8598700737492857 0.9637489484572447 0.9358796247188842 1.0 12.17820170875056 -8.58033340274801 0.6623142924898723 1.0003694242671661 0.903458584829927 0.29599093755538963 0.04408501534684243 1.054383671272454 1.0489822712073933 0.04227383224700304 0.017000213392847678 2.628249541071225e-09 8.58033340274801 -0.0969108394372391 TIGGGDDSFNTFFSET(ph)GAGK ddPTM_A459_Selumetinib_30min_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 1 TIGGGDDSFNTFFS(0.01)ET(0.99)GAGK 130.95 0.00066926 0.0 292.26 433.87 362.19 239.46 472.1 384.16 305.09 486.23 172.87 281.41 True False 299.06908936103497 383.0722986993092 313.00658736726024 197.6428062209086 429.39863835602495 380.295699189372 282.07681567063185 473.3336009023704 293.34776407474914 317.5317146655256 0.9418558069894266 1.206406418655917 0.9857490540652547 0.622434853252681 1.3523015765790047 1.1976620968080598 0.8883421801433584 1.4906655903677521 0.9238376846349008 1.0 8.310756883409594 -6.294107370687525 24.998050117218213 1.156754817926477 0.961534936876139 0.1666526046934269 0.2186780292953747 1230.1126174669146 941297.7363697331 0.06692085674513079 0.07588649763962332 5.080338257569079e-07 6.294107370687525 -0.19521988105033805 TIGGGDDSFNTFFSETGAGK ddPTM_A459_Selumetinib_30min_R1 2 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 ; 347.55 2.3620999999999984e-175 47759000.0 5681.3 5822.8 6688.1 6440.3 6664.3 6210.5 5239.4 6308.1 4779.0 5082.7 False True 5813.66323611458 5141.063869053721 5779.892755103606 5315.622504403733 6061.515241677729 6148.028008682828 4844.187839734857 6140.788696403436 8109.613955650068 5735.114054690547 1.0136961847096642 0.8964187669204288 1.0078078134080761 0.9268555871275608 1.0569127630025474 1.071997513921205 0.8446541417555536 1.0707352352271184 1.414028366012617 1.0 12.485606462184837 -8.007787111329124 24.957261888647558 1.2188034197356827 0.9760860660073929 0.3976202426651668 0.11409878900279248 292.034340948399 935948.9969000614 0.06164833092359728 0.027518451765214173 9.822293082176745e-09 8.007787111329124 -0.24271735372828984 TIGGGDDSFNTFFSETGAGK ddPTM_A459_Selumetinib_30min_R2 2 TIGGGDDSFNTFFSETGAGK 20 0 Q9BQE3;F5H5D3;A0A1W2PQM2;F8VVB9;F8VQQ4;F8VS66;F8VRZ4;F8VWV9;F8VX09;F8VRK0;F8VXZ7;F8W0F6;P68363;P68363-2 Q9BQE3;P68363 TUBA1C;TUBA1B;TUBA1A Tubulin alpha-1C chain;Tubulin alpha-1B chain 0 ; 141.06 0.00086132 7767000.0 39798.0 28985.0 34158.0 42770.0 43316.0 31054.0 35096.0 37773.0 30187.0 37346.0 False True 37586.186484016886 31208.05629853556 31960.31146841841 36944.6522176347 37874.25683004675 35331.40661985516 36728.03354140467 37882.91317634323 36225.24349525246 36267.72394343895 1.036353605829639 0.8604911724597288 0.881232897831192 1.018664757547274 1.0442964904308099 0.974183179373373 1.0126919902303104 1.044535169491839 0.9988286982592915 1.0 15.146398588366118 -5.774562221206935 24.993439879236373 1.0148045042278946 0.9194724227718251 0.41339352178257915 0.04743396597938425 192.67718869407975 366967.86988861667 0.013146010424413499 0.01963095568550875 1.6804971442675682e-06 5.774562221206935 -0.09533208145606953 TIGYTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TIGYTSPR 8 0 Q8IZD2-6;Q8IZD2-5;Q8IZD2-2;Q8IZD2-7;Q8IZD2;Q8IZD2-8 Q8IZD2-6 KMT2E Histone-lysine N-methyltransferase 2E 1 TIGYT(0.004)S(0.996)PR 85.86200000000002 0.03468 10012000.0 110230.0 99307.0 113600.0 113100.0 127630.0 87784.0 92265.0 103360.0 97548.0 108760.0 True False 104103.85788565202 106923.52757766686 106291.09967832806 97695.58489161749 111595.97837332315 99875.4491761889 96555.50531962904 103660.76048783078 117060.32571884885 105619.81620758346 0.9856470274578778 1.0123434353220337 1.006355658387298 0.9249740096082745 1.056581826974535 0.9456127908790839 0.9141798271061221 0.9814518166183666 1.1083178320323943 1.0 16.688521010481253 -8.163691064903295 9.232881952294468 1.0539227260236266 0.9778923654669287 0.29441939631449054 0.04692862721268146 0.4217211197759869 36.323149906169775 0.031490300591295727 0.011860204728531179 6.859760215316538e-09 8.163691064903295 -0.07603036055669787 TIHGVGEMMTQMVLSR ddPTM_A459_Selumetinib_30min_R1 1 TIHGVGEMMTQMVLSR 16 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 62.378 0.03368 0.0 793.7 918.8 1518.5 1357.3 1083.9 648.16 990.3 961.29 720.6 890.34 False True 812.191665728644 811.2264688614682 1312.2960405234398 1120.2730346765193 985.8614363780874 641.6400988821936 915.6008737048962 935.7934664900139 1222.8055694583456 1004.6238116460105 0.8084535288865202 0.8074927743672795 1.3062561580870042 1.1151169439643533 0.9813239791348544 0.6386869308133442 0.911386792838151 0.9314864486008723 1.2171775696365972 1.0 9.972439660022864 -8.236665122405467 23.686334277822507 1.1085887958194378 0.9420291180525497 0.1283876493145072 0.17797666411630242 802.4255613290134 767191.3771249256 0.13069274817663312 0.049334097713642826 5.798756570148612e-09 8.236665122405467 -0.16655967776688807 TIIQNPTDQQK ddPTM_A459_Selumetinib_30min_R2 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 128.81 0.040163 0.0 17270.0 18677.0 20288.0 30059.0 30109.0 20993.0 25294.0 19156.0 16016.0 25351.0 False True 16310.202537287583 20109.465843979597 18982.692167904228 25964.912345332756 26326.43824212481 23884.595194519854 26470.221119110152 19211.74078855347 19219.64752442983 24619.05076019174 0.6625033067343395 0.8168253942794574 0.7710570302977995 1.0546674848778992 1.0693522873227046 0.9701671858583809 1.075192596861277 0.7803607448431064 0.7806819081549407 1.0 14.5874875162717 -5.691744717238854 7.963374272279279 0.9617442308940926 0.7548273185928956 0.4539490247482574 0.10623471762798245 0.2609121483122367 26.034785565491894 0.03150721110130472 0.05461770919295312 2.03355200246026e-06 5.691744717238854 -0.2069169123011969 TILETS(ph)FHQHR ddPTM_A459_Selumetinib_30min_R2 1 TILETSFHQHR 11 0 Q5M775;Q5M775-4;Q5M775-2;Q5M775-5;Q5M775-3 Q5M775 SPECC1 Cytospin-B 1 TILET(0.052)S(0.948)FHQHR 76.24 0.034234 4920400.0 21493.0 27829.0 26012.0 25539.0 25948.0 21023.0 26002.0 19022.0 20700.0 28480.0 True False 20298.505103296007 29963.394815661435 24338.416239724207 22060.54414276767 22688.180261936777 23918.72742220698 27211.144521985538 19077.350870738384 24840.578406324777 27657.708400073392 0.7339185448654938 1.0833650562163684 0.8799867251351751 0.7976273313630399 0.8203203220508526 0.8648123364459042 0.9838539089490629 0.6897661438460954 0.8981430437764996 1.0 14.755394005422893 -5.409038866483665 0.004275583422635115 1.731289809399977 2.8852069892999917e-07 0.026075935450841747 0.11455672429404887 315858.3444596405 261.73469520594534 51678.84807468201 54321.27849371897 3.899070910093385e-06 5.409038866483665 -1.731289520879278 TIMQVSS(ph)GSRGSSGEAT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 TIMQVSSGSRGSSGEATR 18 1 K7EJ87 K7EJ87 POLR2E 2 T(0.019)IMQVS(0.419)S(0.51)GS(0.051)RGSS(0.045)GEAT(0.955)R 88.329 0.022045 101720000.0 0.0 61.382 64.82 0.0 151.12 115.73 63.58 0.0 0.0 0.0 True False 0.0 54.19536690428239 56.0178000307734 0.0 137.45122268240297 114.5658612744326 58.78410941144832 0.0 0.0 0.0 0.0 TINEVENQILTR ddPTM_A459_Selumetinib_30min_R1 2 TINEVENQILTR 12 0 O43707;O43707-2;F5GXS2;O43707-3;H7C144;P12814-4;P12814-3;P12814;P12814-2;H9KV75;H7C5W8;H0YJ11;H0YJW3 O43707;P12814-4 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 ; 184.98 0.0014472 20318200.0 1631.6799999999998 1433.09 1884.2200000000003 1757.57 1701.9299999999998 1561.52 1585.3000000000002 1502.13 1094.3899999999999 1514.15 False True 1669.6949693034055 1265.3031565745337 1628.353273279602 1450.6433931749873 1547.990732000147 1545.8125265467206 1465.719544667648 1462.2886327941058 1857.0998989169018 1708.5059015699717 0.9772837002020875 0.7405904512310011 0.9530861273486289 0.8490713387890374 0.9060493912123307 0.9047744729042202 0.8578955116987166 0.8558873758939824 1.0869730664731008 1.0 10.738519515836366 -8.256958883419264 24.9929025473661 1.0434865410072516 0.8781794102545389 0.5061480313765281 0.06433136539482538 255.1250357995043 1423147.324124155 0.04288657231785373 0.014982727266705409 5.534024997996211e-09 8.256958883419264 -0.16530713075271264 TIPIDGNFFT(ph)YTR ddPTM_A459_Selumetinib_30min_R1 2 TIPIDGNFFTYTR 13 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 TIPIDGNFFT(0.974)YT(0.026)R;TIPIDGNFFT(0.978)YT(0.022)R 153.41 0.00096424 47851000.0 2440.75 3011.5 2506.8 2612.3 2490.6 2255.75 2142.06 2489.0 1400.49 1991.81 True False 2497.614726127238 2658.9121799916325 2166.39032886675 2156.110843944205 2265.3256697511442 2233.059203057128 1980.4826896176 2422.9836345885683 2376.529242257452 2247.478215372376 1.1112965229402316 1.1830647175154432 0.9639205016756123 0.9593467154416745 1.007941102279299 0.9935843594760455 0.8812021740951387 1.0780899312018977 1.057420368305414 1.0 11.134091416541272 -5.2634250724285145 24.99970192432215 0.9908814169021651 1.1471806271425038 0.5704161786149385 0.05361012174068186 116.50396802951701 1466794.0334724318 0.014403348809256016 0.03267519050095023 5.4522395348745544e-06 5.2634250724285145 0.15629921024033866 TIPIDGNFFT(ph)YTR ddPTM_A459_Selumetinib_30min_R2 1 TIPIDGNFFTYTR 13 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 1 TIPIDGNFFT(0.877)Y(0.051)T(0.072)R 100.11 0.026173 5453200.0 18242.0 13353.0 15204.0 14634.0 12014.0 14681.0 12600.0 15474.0 11204.0 10892.0 True False 17228.182668511876 14377.132163337772 14225.791192863555 12640.823954941936 10504.693913477284 16703.17448915096 13185.924966426343 15519.026778141395 13445.113065916074 10577.519659185373 1.6287544928882414 1.359215830041296 1.3449080362152834 1.1950650400318394 0.9931150451093845 1.5791201555126537 1.246598956209537 1.4671706863399574 1.2711026307798465 1.0 13.36871374661293 -4.5974505381664175 1.6807304064003097 1.2764398490431192 1.8924838859425381 0.2909246103049241 0.17208048601355527 2.2374271261629763 4.301949258071547 0.04686790541686056 2.584190009799243 2.5266754570174774e-05 4.5974505381664175 0.6160440368994189 TIPIDGNFFTYTR ddPTM_A459_Selumetinib_30min_R2 2 TIPIDGNFFTYTR 13 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 163.12 0.0050296 23953100.0 39615.0 26260.0 38740.0 44616.0 47309.0 29494.3 30813.0 37046.0 23864.0 42215.0 False True 37413.356891409836 28274.057560791593 36247.5105769228 38539.223833107084 41365.620472173825 33556.8721024021 32245.865554801185 37153.79772670454 28637.46681587125 40996.143262257654 0.9126067457631741 0.6896760356192233 0.8841687947337575 0.940069498405415 1.0090124870418316 0.818537292343195 0.7865585147490629 0.9062754388632821 0.6985405098395148 1.0 15.32320057322823 -12.024841041113826 2.3222762490857285 3.1669516282834667 0.8520774757549179 0.17569357873536706 0.09765642360625491 11095136.468330573 1097906.6371363911 126737638.17609823 0.024612797506895746 9.444064812577677e-13 12.024841041113826 -2.3148741525285486 TIPSWATLSAS(ph)QLAR ddPTM_A459_Selumetinib_30min_R2 1 TIPSWATLSASQLAR 15 0 Q5SSJ5;B0QZK4;Q5SWC8;Q5SSJ5-2 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 TIPSWAT(0.05)LS(0.173)AS(0.777)QLAR 75.968 0.03767 1719200.0 6418.1 8051.0 7378.8 4167.3 7550.5 6271.0 5826.6 5475.8 5058.6 7309.1 True False 6061.407695689956 8668.485811954799 6904.0560414299935 3599.706551006528 6601.938687673566 7134.773327529845 6097.548445188866 5491.733671432507 6070.461349093454 7098.067291677543 0.8539518500757148 1.2212459329765113 0.9726670314220567 0.507138972213911 0.9301037051894837 1.0051712718890873 0.8590434824896939 0.7736942248873218 0.8552273597365084 1.0 12.79321053628119 -5.531720693943993 24.99913176174113 0.839959842587695 1.052438367074319 0.20166778500116322 0.15642398227107435 253.1220361832688 715658.1826918852 0.04207500715493871 0.0730126493810705 2.939539538369234e-06 5.531720693943993 0.21247852448662397 TIQAPTQVPVVVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TIQAPTQVPVVVSPR 15 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 TIQAPTQVPVVVS(1)PR;TIQAPTQVPVVVS(1)PR 147.49 0.00032297 17002400.0 44923.0 39279.0 54364.0 49953.0 57088.0 39194.0 46252.0 44851.0 33534.0 53892.0 True False 42426.35950101741 42291.572998108626 50866.27942704776 43149.31522626858 49916.095066804635 44592.61773229229 48402.80964659933 44981.50898451722 40241.73701824616 52335.997931768055 0.8106534923883533 0.8080780852453672 0.9719176367547934 0.8244672296594704 0.953762172107269 0.85204485429759 0.9248473624158933 0.8594755189948017 0.7689112390808038 1.0 15.675515987069861 -5.129955472394254 17.12481189654023 0.888723953848106 0.8092153728056262 0.19906222186114653 0.06747437536333006 2.7054124695090382 353.3200140127276 0.016192235146244106 0.042843781925812605 7.41386250699528e-06 5.129955472394254 -0.07950858104247982 TIQEVLEEQS(ph)EDEDR ddPTM_A459_Selumetinib_30min_R1 2 TIQEVLEEQSEDEDR 15 0 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 TIQEVLEEQS(1)EDEDR;TIQEVLEEQS(1)EDEDR 172.56 3.8265e-05 52399000.0 5775.3 7223.6 4808.3 4982.5 5965.6 4364.7 6807.5 6112.0 3239.9 6422.6 True False 5909.853253222427 6377.857553839466 4155.359270101325 4112.399908108567 5426.012533312224 4320.79508083052 6294.004794250306 5949.889905426005 5497.873667066469 7247.003271421781 0.8154892487116236 0.8800682592472738 0.5733900088727419 0.5674621293915546 0.7487250012304328 0.5962181772249743 0.8684975787261501 0.8210138291076972 0.7586409804376765 1.0 12.823168830242215 -8.718674262693758 0.6382441951144828 0.9973926912981929 0.7044146795470625 0.3654339767564193 0.10961538051169609 1.226746696233854 1.0699035630923819 0.1251184269687517 0.0488540582096988 1.911286258162673e-09 8.718674262693758 -0.29297801175113036 TIQEVLEEQS(ph)EDEDR ddPTM_A459_Selumetinib_30min_R2 4 TIQEVLEEQSEDEDR 15 0 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 TIQEVLEEQS(1)EDEDR;TIQEVLEEQS(1)EDEDR;TIQEVLEEQS(1)EDEDR;TIQEVLEEQS(1)EDEDR 206.81 1.9662e-06 53743900.0 99736.0 72534.0 89871.0 104181.0 103065.0 98786.0 105701.0 111558.0 115406.0 84852.0 True False 94193.07239484155 78097.12456643007 84088.79770414627 89991.36807775067 90117.05328720949 112392.87480997662 110616.30594255812 111882.61531057903 138490.4247130586 82402.10228802744 1.1430906467119015 0.9477564576380613 1.0204690823326712 1.0921003903904756 1.0936256574160608 1.3639564002520197 1.342396648521309 1.3577640885848483 1.6806661586009133 1.0 16.33039352426161 -6.722023835184175 3.404692768084673 1.3750076782869918 1.0453360801920686 0.4456806135816834 0.16054301728474923 0.20291583002061916 4.851894500125935 0.054783897650812145 0.05231234003878589 1.8966018280294673e-07 6.722023835184175 -0.3296715980949232 TIQEVLEEQS(ph)EDEDREAK ddPTM_A459_Selumetinib_30min_R1 7 TIQEVLEEQSEDEDREAK 18 1 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK 151.84 6.028600000000001e-05 587448300.0 9056.17 10919.869999999999 11091.04 12339.0 9817.099999999999 9641.29 10428.4 10062.25 6160.65 9172.46 True False 9267.161140760705 9641.366543890159 9584.937686721834 10184.225281716326 8929.145038349774 9544.307376190916 9641.777392046992 9795.366443205632 10454.173093926673 10349.834588326454 0.8953921979790003 0.9315478872256207 0.9260957365958926 0.9839988450832907 0.8627331154085235 0.9221700399884565 0.9315875833341262 0.9464273423513256 1.010081176149221 1.0 13.337320090220128 -8.115280644728566 2.5183260225760202 1.006778897336903 0.9225316268711404 0.5597144332600164 0.028992972286960596 0.22480341218047223 2.562486061315251 0.024819597118597415 0.007836339290853325 7.668657741307033e-09 8.115280644728566 -0.08424727046576252 TIQEVLEEQS(ph)EDEDREAK ddPTM_A459_Selumetinib_30min_R2 5 TIQEVLEEQSEDEDREAK 18 1 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 T(0.001)IQEVLEEQS(0.999)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK;TIQEVLEEQS(1)EDEDREAK 133.41 0.00024015 351032000.0 118110.3 107234.0 103535.5 107116.2 103485.2 83608.1 102563.6 89584.8 68241.2 91897.6 True False 111546.20235899251 115458.50298834436 96874.13865092899 92526.78877424817 90484.46400657392 95124.35685623487 107333.01062591778 89845.47693643809 81891.34681843914 89244.27750936031 1.249897533735909 1.2937356456971103 1.085494121914634 1.0367811960217121 1.0138965380394673 1.0658874665242017 1.2026878767062712 1.0067365599661526 0.9176089392381492 1.0 16.44547204366542 -5.342198783233924 4.006665860929425 1.0437093784100266 1.2731131971511929 0.6457822666597373 0.06881183416144804 0.14314326410712402 4.276096085898588 0.019527304961572567 0.045057578815816915 4.54779852801999e-06 5.342198783233924 0.22940381874116622 TIQEVLEEQS(ph)EDEDREAKR ddPTM_A459_Selumetinib_30min_R1 1 TIQEVLEEQSEDEDREAKR 19 2 P18858-3;P18858;M0R0Q7;P18858-2 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 TIQEVLEEQS(1)EDEDREAKR 81.696 0.0063021 27013000.0 1135.0 1183.0 1215.4 1981.3 1782.8 1107.4 1071.4 1185.0 463.85 737.62 True False 1161.4432916744502 1044.493810038221 1050.3553557143164 1635.3031486072252 1621.546054778905 1096.260561438751 990.5834354109109 1153.569950577523 787.1195717364056 832.3007120272375 1.3954611294822985 1.2549476348447954 1.261990216439876 1.964798449618182 1.948269455194025 1.3171448078766934 1.1901749224726044 1.386001398181877 0.9457153650862751 1.0 9.700961061131595 -7.742834855694069 1.1808693937114365 1.0082613557917202 1.5351924751388948 0.3889615171669736 0.2552082054622837 0.602251466990217 1.5261742490231531 0.2438891334706057 0.09663297602000573 1.807861450578583e-08 7.742834855694069 0.5269311193471746 TIS(ph)AQDTLAYATALLNEK ddPTM_A459_Selumetinib_30min_R1 1 TISAQDTLAYATALLNEK 18 0 Q9UPU5;A0A0U1RQI9 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 T(0.002)IS(0.998)AQDTLAYATALLNEK 260.98 1.1607e-42 151400000.0 3467.5 4306.9 3433.3 3938.1 3512.4 4398.1 3820.7 3818.3 2054.6 3114.3 True False 3548.2860034195187 3802.646145776509 2967.076717766959 3250.3847622924914 3194.704040164585 4353.859107155295 3532.5015229367805 3717.026280413634 3486.5061379532576 3514.05074085088 1.0097423927806886 1.082126134825176 0.8443465779462597 0.9249680787208708 0.9091229113530188 1.238985839487641 1.0052505736105086 1.0577611294006546 0.9921615807713258 1.0 11.778919307836897 TIS(ph)AQDTLAYATALLNEK ddPTM_A459_Selumetinib_30min_R2 1 TISAQDTLAYATALLNEK 18 0 Q9UPU5;A0A0U1RQI9 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 T(0.005)IS(0.972)AQDT(0.023)LAYATALLNEK 98.175 0.0033361 83933000.0 56184.0 36038.0 65198.0 82170.0 66903.0 40050.0 53496.0 53141.0 43183.0 90589.0 True False 53061.51820237206 38801.99871956617 61003.231662215105 70978.3042488438 58498.04701959137 45566.523962297906 55983.67000031302 53295.631512033884 51820.806633832035 87973.46019151133 0.603153702114948 0.4410648238127414 0.6934276715888615 0.8068149654944751 0.6649510760659602 0.517957618844401 0.6363699902043293 0.6058148832160685 0.5890504536370651 1.0 16.42478073710624 -11.661589233256988 2.2191581766026895 1.774274900054347 0.6188887147729648 0.6035803943175524 0.09296070977311117 8160803.179536361 1924855.7189369914 31811578.41222004 0.026261726371319294 2.1797704799054157e-12 11.661589233256988 -1.1553861852813823 TIS(ph)DGTISASK ddPTM_A459_Selumetinib_30min_R1 2 TISDGTISASK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 1 T(0.104)IS(0.637)DGT(0.248)IS(0.011)ASK;T(0.012)IS(0.981)DGT(0.007)ISASK 158.01 0.00056772 115909000.0 7191.6 8555.7 7594.200000000001 8496.5 7920.599999999999 7313.2 7677.8 7243.9 3808.6000000000004 6790.0 True False 7359.150287582355 7553.994666562975 6562.949351954634 7012.745774058087 7204.183128495506 7239.63584785432 7098.657364567756 7051.768240496639 6462.916030861863 7661.562640200839 0.9605286327580614 0.9859600477488174 0.8566071518515437 0.9153153349241893 0.9403020593598719 0.9449294077251766 0.926528659743709 0.920408612662832 0.8435506350819896 1.0 12.903422956622963 -7.822365518813259 4.228479159892261 0.9103053206760336 0.9321705723191478 0.0 0.047425524846293574 0.8944150812536706 31.736159207458265 0.027093150803371293 0.012635654480653522 1.505339581628228e-08 7.822365518813259 0.021865251643114147 TIS(ph)DGTISASK ddPTM_A459_Selumetinib_30min_R2 1 TISDGTISASK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 1 T(0.002)IS(0.966)DGT(0.03)IS(0.003)ASK 81.676 0.041434 49000000.0 97150.0 80641.0 128400.0 117300.0 100920.0 89367.0 98045.0 96186.0 84827.0 94348.0 True False 91750.79192226348 86825.90539831652 120138.88379134984 101323.53764621358 88241.5273637528 101676.4930571456 102604.28677248188 96465.88533555043 101794.77026441135 91623.9280944567 1.0013846145919 0.9476335189297515 1.3112173456206393 1.1058632799693697 0.9630838711999237 1.1097154986885691 1.1198416058598288 1.0528459905812166 1.1110063973623718 1.0 16.483436794849297 -11.009456284631128 5.638024348123052 0.9998958734523195 1.0817052199782358 0.05699635340897691 0.0978199603844246 0.00013089764218228566 1.1919989716261119e-05 0.09683385703226374 0.02345580964709977 9.784614401484846e-12 11.009456284631128 0.08180934652591632 TIS(ph)EPDEQR ddPTM_A459_Selumetinib_30min_R2 2 TISEPDEQR 9 0 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 1 T(0.077)IS(0.923)EPDEQR;TIS(1)EPDEQR 181.4 0.0013768 49119000.0 182216.0 118940.0 192708.0 157128.0 166051.0 128688.0 131545.0 161469.0 110661.0 138952.0 True False 172089.16418844217 128062.31554762194 180309.37708460563 135726.89533908133 145190.18886522503 146413.60388664654 137662.10315147263 161938.84805736804 132796.29212668142 134940.0947193466 1.2753004549638087 0.9490308704315843 1.336217952563467 1.0058307400878228 1.0759603301538876 1.0850266867765503 1.0201719765929271 1.2000795493302003 0.9841129310222885 1.0 17.041959554066665 -1.522878745280345 0.14703828282493467 0.9993100702194643 1.6200431948477854 0.1591952673820377 0.11538437206654377 155.34981669179368 1.5100965783772158 0.41069036852370266 20.468533254700237 0.02999999999999949 1.522878745280345 0.6207331246283211 TIS(ph)NPEVVMK ddPTM_A459_Selumetinib_30min_R1 2 TISNPEVVMK 10 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6;F8W9I4;E9PFY5 A8MQ02 MLLT4 Afadin 1 T(0.144)IS(0.856)NPEVVMK;T(0.127)IS(0.873)NPEVVMK 151.66 0.00066327 83475000.0 6943.1 7765.6 8998.7 9216.1 7397.1 6562.9 7375.0 7051.9 3741.1 4998.4 True False 7104.8607210791815 6856.399941870501 7776.725966320895 7606.681142623053 6728.033611064074 6496.883184636424 6818.697812353433 6864.860704200532 6348.373460866801 5639.993328539005 1.2597285683172321 1.2156751865602997 1.3788537527109794 1.3487039256114692 1.1929151719062256 1.1519310052658145 1.208990403915914 1.2171753234996856 1.1255994628120058 1.0 12.461477740745485 -6.41365701254984 4.864133529320884 1.1598126349810194 1.2995666909228472 0.525193779163239 0.07067347695623863 0.20928714298582976 7.635093225200776 0.022578883804972905 0.02553267517191934 3.8578291244797246e-07 6.41365701254984 0.13975405594182777 TIS(ph)NPEVVMK ddPTM_A459_Selumetinib_30min_R2 2 TISNPEVVMK 10 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6;F8W9I4;E9PFY5 A8MQ02 MLLT4 Afadin 1 T(0.043)IS(0.957)NPEVVMK;T(0.052)IS(0.948)NPEVVMK 137.09 0.0017840999999999996 39166000.0 515510.0 480550.0 504990.0 522850.0 457470.0 326269.0 377450.0 376570.0 359038.0 456680.0 True False 486860.017950036 517406.6397882092 472499.4931915387 451636.928033441 399998.5287663103 371209.5931749061 395002.1729029856 377665.7563554801 430855.63235990494 443494.4618028632 1.0977815054801048 1.166658626772662 1.0654011129491139 1.0183597923578969 0.9019245181557933 0.8370106622434255 0.8906586370825238 0.8515681454515107 0.9715017197924416 1.0 18.758556563225987 -5.940251503872018 1.823607702955864 0.8959990630509846 1.1273632118483703 0.7572775387922217 0.051428867305391354 0.15081788605850419 1.0166388500657586 0.016206366043617335 0.02789449007091515 1.1474889078143319e-06 5.940251503872018 0.23136414879738565 TIS(ph)PMVMDAK ddPTM_A459_Selumetinib_30min_R2 1 TISPMVMDAK 10 0 P18206;P18206-2 P18206 VCL Vinculin 1 T(0.003)IS(0.997)PMVMDAK 132.03 0.0025097 2178000.0 14860.0 13868.0 17021.0 21639.0 19377.0 15047.0 16912.0 18575.0 16791.0 12480.0 True False 14034.140689293205 14931.631007351774 15925.887391063578 18691.73087064291 16942.688027422104 17119.587666933763 17698.441510492237 18629.050174743206 20149.6691797391 12119.669973065864 1.1579639314009345 1.2320163041184347 1.3140528930619775 1.5422640147943352 1.3979496195090022 1.4125456967870793 1.460307215445994 1.5370921993869022 1.6625592301208445 1.0 13.565062793318743 -5.441258944022404 2.6660656200493684 1.4516984518308633 1.1886436578227606 0.2367060285001512 0.16529010667260977 0.35067275163115763 4.809699307881027 0.04360763601519269 0.10734715691273992 3.6202707879377183e-06 5.441258944022404 -0.2630547940081027 TIS(ph)QEFLTPGK ddPTM_A459_Selumetinib_30min_R2 1 TISQEFLTPGK 11 0 E7EUA0;Q0ZGT2-2;Q0ZGT2;E7ETM8;Q0ZGT2-4;Q0ZGT2-3;H7BXY5 E7EUA0 NEXN Nexilin 1 T(0.349)IS(0.651)QEFLTPGK 107.65 0.010426 3934800.0 16631.0 16165.0 18837.0 20775.0 24502.0 19337.0 20176.0 19724.0 20353.0 18801.0 True False 15706.715599167908 17404.803521332662 17625.047928174867 17945.409161126037 21423.83970934078 22000.496226191146 21114.223977985544 19781.393574516023 24424.168710334707 18258.166279135516 0.8602570137131859 0.9532613108700827 0.9653240998421543 0.9828702886572525 1.173383974152039 1.2049674589354666 1.1564263165964144 1.0834271783974918 1.337712031807125 1.0 14.156254258078553 -6.156511035710566 2.9856011080597873 1.166798744148538 0.9317769827642898 0.6155210782436957 0.08530362773645785 0.17254851816645247 2.961834514581818 0.025490479185931846 0.03415393330645313 6.974112749739423e-07 6.156511035710566 -0.23502176138424813 TIS(ph)QSSSLK ddPTM_A459_Selumetinib_30min_R1 2 TISQSSSLK 9 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 T(0.27)IS(0.723)QS(0.005)S(0.002)SLK;T(0.466)IS(0.497)QS(0.026)S(0.009)S(0.002)LK 147.28 0.0016555999999999995 105241000.0 9696.0 9979.1 11248.5 12468.5 10150.7 9370.900000000001 10026.5 9491.3 5545.4 7577.8 True False 9921.897934868257 8810.742332842272 9721.015483587697 10291.11053773239 9232.570977251646 9276.637254096437 9270.193032618543 9239.559891912602 9410.138780008756 8550.484444022673 1.1603901509702514 1.030437794551107 1.1368964585840862 1.2035704649374017 1.0797716828437474 1.0849253413450028 1.084171673933515 1.080589053450841 1.1005386702489162 1.0 13.061790445618497 -6.475246656293407 24.98610988203923 1.0766738871940287 1.1277850755720586 0.2756286558528589 0.047910407306711825 656.7943372276858 344531.3996263553 0.014977097532469629 0.016981990340957973 3.347752505202757e-07 6.475246656293407 0.05111118837802997 TIS(ph)QSSSLK ddPTM_A459_Selumetinib_30min_R2 2 TISQSSSLK 9 0 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 T(0.435)IS(0.565)QSSSLK;T(0.204)IS(0.717)QS(0.06)S(0.013)S(0.005)LK 105.2 0.013882 197971000.0 171561.0 132782.0 165320.0 190659.0 180612.0 168619.0 150931.0 170520.0 134926.0 189120.0 True False 162026.3264330977 142965.95243857702 154683.49118680647 164690.91529487987 157921.90586823373 191844.73667911917 157949.59056410257 171016.18496889446 161914.97014742906 183659.61420722894 0.8822098812114366 0.7784289053186403 0.8422292067556681 0.8967181816523578 0.8598619056775622 1.0445668064109876 0.860012644837003 0.9311583589407495 0.8816035623636631 1.0 17.486674894634028 -6.046608556758327 1.6266613201457452 0.9310950610512968 0.8275537064970844 0.3506582135546603 0.059110580824947974 0.4206800124315219 2.2354889673674943 0.0196350774294505 0.03183371212360914 8.982380398726264e-07 6.046608556758327 -0.10354135455421243 TIS(ph)VLASPSVPLLQHR ddPTM_A459_Selumetinib_30min_R1 1 TISVLASPSVPLLQHR 16 0 A0A1B0GTU4;A0A1B0GV30 A0A1B0GTU4 1 T(0.202)IS(0.798)VLASPSVPLLQHR 86.573 0.010194 4225200.0 3604.4 2608.5 3125.1 2657.8 1969.0 2713.1 1617.7 1879.7 1877.5 1761.7 True False 3688.375507058489 2303.095607341249 2700.7285849455393 2193.665123084987 1790.9042976551834 2685.8086772977026 1495.6755865822572 1829.844249873898 3185.9803728254847 1987.831355411166 1.8554770740577133 1.1585970817252116 1.3586306391604919 1.1035468965279733 0.9009337199456491 1.3511250187228112 0.7524157331107646 0.9205228828355061 1.6027417839812128 1.0 10.956979650700914 -2.208468418005719 1.04860704769911 1.089467187285099 199.99997911472065 0.4441814036210264 0.24258451731215486 400.4204350477541 2.2121620652371408 0.07388700042861845 189383.4874798156 0.006187733232550798 2.208468418005719 198.91051192743555 TIS(ph)VSGSTAK ddPTM_A459_Selumetinib_30min_R2 1 TISVSGSTAK 10 0 Q8TDJ6-3;Q8TDJ6 Q8TDJ6-3 DMXL2 DmX-like protein 2 1 T(0.028)IS(0.969)VSGS(0.002)TAK 97.734 0.019077 0.0 59325.0 48724.0 70196.0 66008.0 58795.0 50365.0 46902.0 55918.0 42341.0 61162.0 True False 56027.95399679134 52460.97412764696 65679.66578362593 57017.596529848815 51408.646466030994 57302.32158205078 49083.035934549844 56080.712122276775 50810.38310638634 59396.09414203959 0.9432935752106242 0.8832394601939983 1.1057909906762526 0.9599553195113665 0.8655223413023179 0.9647489857669468 0.826368074257086 0.9441818175478942 0.8554499052560356 1.0 15.858080442777814 -6.018697789246245 24.443661576786745 0.9058904400527884 0.9788297994303731 0.1628972881096441 0.0712771247640419 948.6235599184646 1240138.8653983432 0.020402391298407888 0.02683693477368257 9.578603818865516e-07 6.018697789246245 0.07293935937758467 TISET(ph)IER ddPTM_A459_Selumetinib_30min_R1 1 TISETIER 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 1 TIS(0.015)ET(0.985)IER 111.61 0.026956 2849500.0 717.98 1173.5 923.57 932.99 1282.7 763.3 1021.5 936.88 661.88 671.62 True False 734.707537054116 1036.1060744546514 798.1542668068712 770.060810891362 1166.6800114790778 755.6218950209486 944.4474325856323 912.0308989848686 1123.16201819746 757.8289691327965 0.9694899073267956 1.3672030453524293 1.0532116075217077 1.016140636287054 1.5395030527984965 0.9970876355988694 1.2462540639827853 1.2034785368900973 1.4820784952081254 1.0 9.565728479826417 TISGPLIPPAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TISGPLIPPASPR 13 0 A0A0A0MSG0;A6NGB9 A0A0A0MSG0 WIPF3 WAS/WASL-interacting protein family member 3 1 TISGPLIPPAS(1)PR;TISGPLIPPAS(1)PR 117.48 0.0036085 7490000.0 27845.0 25748.0 33125.0 30937.0 31752.0 21538.0 22044.1 25361.0 20152.8 23079.1 True False 26297.486372366686 27722.788807131044 30993.773563773055 26723.327230698276 27763.029893518455 24504.663997502455 23069.19432955547 25434.796311260438 24183.92311627931 22412.746416296817 1.1733272613678967 1.2369206473943406 1.382863705682976 1.1923272023131952 1.2387161027856597 1.093336066109442 1.0292890438800189 1.134836215019424 1.0790254200482379 1.0 14.45203182439949 -6.773827393901973 3.7399397235080927 1.0702051144349807 1.2514804086900941 0.6759298684871761 0.06162046833785305 0.14112948573394693 4.257875307018335 0.022537425884036445 0.020858262315496656 1.6833429563475555e-07 6.773827393901973 0.18127529425511346 TISINS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TISINSPK 8 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 TIS(0.012)INS(0.988)PK 118.9 0.0081392 107270000.0 4605.5 5645.1 6489.1 6603.3 4658.8 5122.0 4862.8 5011.3 3676.0 5042.2 True False 4712.799189256986 4984.169067664207 5607.915862074845 5450.157614292681 4237.412362577946 5070.477330403903 4495.995080937261 4878.384045003495 6237.903515582684 5689.41548518714 0.8283450561006039 0.8760423774007894 0.9856752203588425 0.9579468450638934 0.7447886999306689 0.8912123474907583 0.7902384862984525 0.8574490749892969 1.0964049877924327 1.0 12.474064726308477 -8.254058976393218 24.93889899701935 1.048202497591714 0.8680332716414446 0.5132450153383904 0.07078198421828828 414.01084989947844 1398983.74298739 0.0524004044424447 0.018915199250569635 5.571100892676333e-09 8.254058976393218 -0.1801692259502693 TISINS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 TISINSPK 8 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 TISINS(0.999)PK;T(0.001)ISINS(0.999)PK;TISINS(1)PK 125.72 0.005018 156538000.0 1682790.0 1620460.0 1609410.0 1482360.0 1395090.0 1038460.0 1304490.0 1251220.0 873140.0 1312850.0 True False 1589267.2685421065 1744744.0713998575 1505862.3127931128 1280460.010786369 1219826.321937158 1181498.4387986984 1365151.3697978961 1254860.8430493781 1047792.397569971 1274944.60930605 1.246538286402216 1.368486174744108 1.1811197928141763 1.0043259930196662 0.9567680925378454 0.9267057017024338 1.070753474177161 0.9842473421119029 0.8218336623583063 1.0 20.28200313906293 -5.653174389206188 2.5592229770400237 0.9639241601440407 1.3071187642247666 0.8207735929151522 0.06588217297841849 0.10789214608134452 1.4242208553881426 0.019109028137972002 0.03814873918295401 2.2224173087063024e-06 5.653174389206188 0.3431946040807259 TISQIKS(ph)ESEMETDSGVPQNTGMK ddPTM_A459_Selumetinib_30min_R2 1 TISQIKSESEMETDSGVPQNTGMK 24 1 Q4G0J3;Q4G0J3-3;H0YA82;D6R9Z6;Q4G0J3-2 Q4G0J3 LARP7 La-related protein 7 1 TIS(0.002)QIKS(0.531)ES(0.365)EMET(0.072)DS(0.03)GVPQNTGMK 81.574 0.00011597 4245900.0 44156.0 42060.0 46519.0 44061.0 40613.0 29695.0 43899.0 34409.0 27736.0 43103.0 True False 41701.98629047312 45285.86675578421 43526.018186057576 38059.815790535504 35510.83185517337 33785.21670562887 45940.39048421828 34509.124493283394 33283.97500859053 41858.50439495655 0.9962607812499319 1.0818797138208458 1.0398369176157651 0.9092492992922426 0.8483540529807366 0.8071290934536969 1.0975162908532763 0.8244232562079148 0.7951544253597568 1.0 15.35323314454665 -5.7810449348989765 4.885072236590899 0.8914601688460622 1.0450686229533375 0.3434658309099611 0.0898672297996077 0.2020828140718833 12.320980682381402 0.02561540467976729 0.04107408595622039 1.6555986557273796e-06 5.7810449348989765 0.1536084541072753 TIT(ph)PETLCHVGVPSR ddPTM_A459_Selumetinib_30min_R2 2 TITPETLCHVGVPSR 15 0 Q9Y2G1-2;Q9Y2G1 Q9Y2G1-2 MYRF Myelin regulatory factor;Myelin regulatory factor, N-terminal;Myelin regulatory factor, C-terminal 1 T(0.002)IT(0.998)PETLCHVGVPSR;T(0.42)IT(0.58)PETLCHVGVPSR 196.65 4.1733e-05 12897700.0 77979.0 59059.0 71902.0 83373.0 77484.0 60343.0 69528.0 85427.0 59618.0 63741.0 True False 73645.23935466998 63588.635395384255 67275.90360097853 72017.45357355279 67749.76720425111 68654.70051078511 72761.18976711822 85675.5784267988 71543.26586610005 61900.631710992864 1.1897332437334625 1.0272695712100726 1.0868371087888442 1.163436488173404 1.0944923392796249 1.1091114680594254 1.1754514898463733 1.3840824569740824 1.1557760218042292 1.0 15.917666512117686 -7.3778014603283335 4.536757584887606 1.215095574398433 1.1086456555324322 0.06408640771466667 0.09782254609800466 0.371746509928221 12.204773974027766 0.04077745570483911 0.026785279798336017 4.189850622444533e-08 7.3778014603283335 -0.10644991886600086 TITLEVEPSDTIENVK ddPTM_A459_Selumetinib_30min_R2 2 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H265;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H2Z3;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;F5GZ39;Q49A90;M0R1V7;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 ; 193.81 1.6327e-05 6086500.0 33492.0 25284.0 32491.0 42873.8 35766.0 26577.9 35916.0 37308.0 30347.0 30903.9 False True 31630.648719098772 27223.201499126197 30400.564433526026 37034.3144785697 31272.75532790313 30238.76447484538 37586.165166203864 37416.560103328135 36417.247966026 30011.62410902487 1.0539465843032148 0.9070885800858688 1.0129596560015623 1.2339990113175188 1.0420214252416624 1.0075684129920914 1.2523869094742273 1.2467355970940777 1.21343809431076 1.0 14.873233773481834 -5.775415277193727 0.7178350630118872 1.1703950601031203 0.9517405843182932 0.23643923332944083 0.10496926377181177 1.4073576080193664 1.255648840385009 0.056994812338552 0.20485100893518374 1.6771994943803835e-06 5.775415277193727 -0.2186544757848271 TITVPVS(ph)GSPK ddPTM_A459_Selumetinib_30min_R2 1 TITVPVSGSPK 11 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 T(0.001)ITVPVS(0.641)GS(0.357)PK 125.82 0.0032771 7164500.0 82070.0 79745.0 78800.0 70496.0 69256.0 53634.0 63653.0 68020.0 46286.0 61210.0 True False 77508.87795224054 85861.1850794107 73730.09379095283 60894.323187616996 60555.442123504436 61021.59665902336 66612.99062602669 68217.92693868285 55544.49333889608 59442.70825732066 1.3039257500972787 1.444435955167579 1.2403555617248077 1.0244204036601505 1.0187194342048966 1.0265615152470489 1.1206250956411121 1.147624812842902 0.934420637405186 1.0 15.85921222726306 -5.586565472762906 3.529252926533551 1.0473516829717477 1.3715543997778534 0.8128810065328985 0.06573491864703311 0.09160070127790648 2.298872489090927 0.0183708860323351 0.035329388558084374 2.590803811117656e-06 5.586565472762906 0.3242027168061057 TITVPVSGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TITVPVSGSPK 11 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 TIT(0.001)VPVS(0.287)GS(0.712)PK 138.02 0.0012852 11039000.0 3885.5 4370.0 5422.8 5343.4 3844.2 3922.8 3432.3 3910.1 3095.0 4126.4 True False 3976.0245901331064 3858.3583684421174 4686.4135453082035 4410.2754980406025 3496.492788748632 3883.3401936174205 3173.398847639416 3806.3914462052076 5251.988950143744 4656.063634539728 0.8539455003660305 0.828673890927939 1.0065183625376881 0.9472111732589277 0.7509546825801223 0.8340393298772656 0.6815626023876541 0.8175127629202786 1.1279890831352277 1.0 12.184895060392721 -8.25494679250406 24.907490239917358 1.0639945478495254 0.8403404932564157 0.49668905081448134 0.09017166814161799 397.7973436564402 1526083.921593185 0.06986750451253143 0.024995056991065176 5.559723679342658e-09 8.25494679250406 -0.22365405459310972 TITVPVSGS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 TITVPVSGSPK 11 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 TITVPVS(0.395)GS(0.605)PK 160.18 0.00059597 6856300.0 111910.0 94855.0 92905.0 86282.0 95686.0 60862.0 91886.0 75039.0 57818.0 81757.0 True False 105690.49021122493 102130.07349310319 86927.59344731564 74530.24275524793 83665.06923630665 69245.18804977214 96158.88106865474 75257.35106662486 69383.21556989779 79396.46297980337 1.3311737858915724 1.2863302678745616 1.094854735146426 0.9387098613474345 1.053763179067424 0.8721444942375647 1.2111229828098935 0.9478678047127691 0.8738829535460197 1.0 16.276787117961028 -5.34452699746843 2.5289550286787708 0.9907252326088439 1.3260415416105915 0.6555749105645681 0.09272978529991754 0.17601298899387213 2.1490364640518687 0.025392444169318996 0.07285800637466673 4.523483416904651e-06 5.34452699746843 0.3353163090017476 TIVMGAS(ph)FR ddPTM_A459_Selumetinib_30min_R1 2 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 TIVMGAS(1)FR;TIVMGAS(1)FR 113.44 0.009110600000000002 18372900.0 4914.4 8167.1 6720.4 8138.799999999999 5814.5 5444.3 5995.0 4570.7 2817.1 4600.299999999999 True False 5028.895958242215 7210.892135218218 5807.806592514805 6717.511364197489 5288.579501633352 5389.535285028892 5542.792323397814 4449.470188273992 4780.412947156683 5190.793315716629 0.9688106715818904 1.3891695732490745 1.1188668550778142 1.2941203695894188 1.0188383894270356 1.0382873979417586 1.0678121794245603 0.8571850038416928 0.9209407226218388 1.0 12.34173932906164 -6.789948102154795 1.1133476961009154 0.9372488224401248 1.200968224172447 0.4136222671815437 0.11880180296768383 0.4343255993024437 1.1415188451854652 0.061311673426009475 0.05384701940587926 1.6220039139560184e-07 6.789948102154795 0.26371940173232233 TIVMGAS(ph)FR ddPTM_A459_Selumetinib_30min_R2 3 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 TIVMGAS(1)FR;TIVMGAS(1)FR;TIVMGAS(1)FR 97.597 0.02045 5402000.0 46016.0 55089.0 61312.0 51948.0 64869.0 39257.0 38871.0 41856.0 34332.4 57273.0 True False 43458.61493664305 59314.14916094623 57367.25267145818 44872.5927847016 56719.57628378208 44664.29541043521 40678.5785214253 41977.794030366196 41199.83932740602 55619.379676875105 0.7813574187471899 1.0664295341935879 1.0314256110862343 0.8067798138956644 1.0197808140489637 0.8030347636006682 0.7313741857199865 0.7547332292132579 0.7407461134367109 1.0 15.76330003394123 -6.854780199504768 7.033239744960761 0.7840903900912 0.9453195958275994 0.2563367676351148 0.11223883307643899 0.26439760180808997 16.994262037534693 0.03827123907858166 0.033797065723461805 1.3970752549985155e-07 6.854780199504768 0.16122920573639943 TIYLS(ph)SPDSAVGVQWPR ddPTM_A459_Selumetinib_30min_R2 1 TIYLSSPDSAVGVQWPR 17 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 T(0.005)IYLS(0.589)S(0.355)PDS(0.052)AVGVQWPR 196.97 8.3011e-08 10509000.0 13251.0 12736.0 14895.0 15359.0 14025.0 14261.0 12960.0 12604.0 11523.0 13292.0 True False 12514.562467955868 13712.810247305475 13936.6719164498 13267.07770424717 12263.05411490917 16225.323301531364 13562.665679752818 12640.675553295472 13827.921979520801 12908.225423236501 0.9695029376716656 1.0623311723872295 1.0796737320191172 1.0278002799954737 0.9500185899166327 1.2569755151876765 1.050699475339053 0.9792729162089621 1.071248876288504 1.0 13.656003057261165 -4.7586133001338995 24.144354482954228 1.0555781975492096 0.9695027655974668 0.09102486635997697 0.07891915249319012 131.52591989098437 1123342.395369512 0.019698477499196874 0.1322678121254659 1.743358485194918e-05 4.7586133001338995 -0.08607543195174272 TIYLSS(ph)PDSAVGVQWPR ddPTM_A459_Selumetinib_30min_R2 1 TIYLSSPDSAVGVQWPR 17 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 TIYLS(0.04)S(0.958)PDS(0.002)AVGVQWPR 199.84 5.8082e-08 12208000.0 12892.0 11960.0 12440.0 14088.0 12944.0 11236.0 9542.5 11319.0 9503.5 14186.0 True False 12175.514250765002 12877.293542538733 11639.623943647899 12169.190096844462 11317.858999171789 12783.657009747296 9986.24515810503 11351.936416038674 11404.465549976214 13776.413320345535 0.8837942044598601 0.9347348430321158 0.8448950879296033 0.8833351478263604 0.8215388676279871 0.9279379699553513 0.7248799034910604 0.8240124734987226 0.8278254495408949 1.0 13.74991271182394 -5.571833322436143 1.1187666083762893 0.8421504398770043 0.9110356397527986 0.03842414517834425 0.07116917800594726 1.552607420380638 3.438669199719025 0.02429832434852077 0.09204624603270269 2.6801967582232284e-06 5.571833322436143 0.06888519987579422 TKADVTPPPDGSTT(ph)HNLEVSPK ddPTM_A459_Selumetinib_30min_R1 1 TKADVTPPPDGSTTHNLEVSPK 22 1 O75362 O75362 ZNF217 Zinc finger protein 217 1 TKADVTPPPDGS(0.052)T(0.127)T(0.665)HNLEVS(0.156)PK 109.71 7.012899999999999e-05 4283800.0 1010.4 1151.6 1409.6 1724.2 1272.7 1324.1 1230.4 1112.5 476.13 817.2 True False 1033.9403541038448 1016.7701366356844 1218.1840623785583 1423.100837242506 1157.5845097134343 1310.780756186608 1137.5899373992777 1082.992886090712 807.9578348406914 922.0955802020801 1.121294122109612 1.1026732569446391 1.3211038947953633 1.543333324437613 1.2553845117224682 1.4215237382434327 1.2337006724942454 1.17449091975191 0.8762191818158643 1.0 9.848772491336733 -8.046787658401325 2.6793907915484416 0.9392771248009018 1.294096827026654 0.5364799143598672 0.12677292904655146 0.2367524990849263 3.1711650408781153 0.11001081684417555 0.037181298671232134 8.978676857749974e-09 8.046787658401325 0.3548197022257522 TKADVTPPPDGSTT(ph)HNLEVSPK ddPTM_A459_Selumetinib_30min_R2 1 TKADVTPPPDGSTTHNLEVSPK 22 1 O75362 O75362 ZNF217 Zinc finger protein 217 1 TKADVTPPPDGS(0.077)T(0.096)T(0.573)HNLEVS(0.254)PK 51.348 0.026035000000000003 12528000.0 116410.0 116210.0 106150.0 122890.0 113870.0 88970.0 95948.0 86125.0 68154.0 123740.0 True False 109940.3982261521 125122.93332595559 99320.42456738156 106152.17000292578 99564.63258928398 101224.80991075277 100409.77211735502 86375.60949123882 81786.70438186772 120167.30468486938 0.9148944341762791 1.0412394091228225 0.8265178687983612 0.8833698174499516 0.8285501022960071 0.8423656515905719 0.8355831262145128 0.7187945982291357 0.6806069637356669 1.0 16.874684893070132 -5.631719065277127 0.7957143578747842 0.7952202166654617 0.9943834017045365 0.2580354740218459 0.09077854917504259 1.2131831232872332 1.2511394825641908 0.04050310170382691 0.17482571460100269 2.3349680088650215e-06 5.631719065277127 0.19916318503907482 TKADVTPPPDGSTTHNLEVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 TKADVTPPPDGSTTHNLEVSPK 22 1 O75362 O75362 ZNF217 Zinc finger protein 217 1 TKADVTPPPDGS(0.057)T(0.057)T(0.242)HNLEVS(0.643)PK 54.66 0.011579 10094000.0 84419.0 72849.0 74224.0 76527.0 77322.0 62087.0 72482.0 67445.0 48247.0 90573.0 True False 79727.32993603239 78436.28405354559 69448.50864898076 66103.89058356163 67608.11909254958 70638.92068032925 75852.55662035829 67641.25378387923 57897.74813381408 87957.9221530843 0.9064257997963256 0.8917478054680851 0.7895651346573505 0.7515399291551325 0.7686416122345706 0.8030990154290751 0.862373220780983 0.7690183229448576 0.6582437001302429 1.0 16.42452590308239 -5.241223482600821 5.483726704053223 0.7913300978486166 0.9010558754588306 0.17839300704725547 0.08313123483951321 0.2591707151445359 26.162685826544976 0.020521999070048598 0.0527573579429937 5.73821104934654e-06 5.241223482600821 0.10972577761021396 TKDGVVEITGK ddPTM_A459_Selumetinib_30min_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 117.79 0.015488 8485500.0 4269.0 4506.6 4591.3 5344.8 3910.4 3780.3 4266.4 4201.5 2551.3 3844.0 False True 4368.459393972005 3978.9651769385 3967.826678205643 4411.431014321859 3556.7050104371924 3742.2736142377757 3944.582013101653 4090.0625716046115 4329.369760420594 4337.414843730782 1.007157385530253 0.9173586849064302 0.9147906808915603 1.0170645818437354 0.8200057265857305 0.8627889535737601 0.9094315750782007 0.9429724199695381 0.9981451893351135 1.0 12.082619718264619 -8.156974955133837 3.0024778560498224 1.0011949842892305 0.9186117998607486 0.23455288517135542 0.055244079746910396 0.40386986082549414 6.525333972831201 0.04838353379890956 0.015216239025955857 6.9666668828201e-09 8.156974955133837 -0.08258318442848189 TKDQMQMKETQPK ddPTM_A459_Selumetinib_30min_R1 1 TKDQMQMKETQPK 13 2 F5GYN0;A6NE01 F5GYN0 FAM186A Protein FAM186A 0 66.056 0.046644 0.0 315.84 423.23 378.36 335.68 365.97 403.24 258.91 314.72 168.18 364.57 False True 323.1984574823419 373.6780348457108 326.9807901827125 277.05978949400566 332.8680781172513 399.1837717126262 239.3802102503633 306.37260324536527 285.38917661879634 411.3661107125211 0.785671082439277 0.9083831290780581 0.7948656480631181 0.6735114592062883 0.8091772011571285 0.9703856523844561 0.5819152429346608 0.7447686993824111 0.6937595713085796 1.0 8.684279135993323 -7.261331172336183 24.999999998372225 0.7338416138201787 0.8187236283544457 0.058692460620399345 0.12228142663384393 24.582419699074606 5680305.265127817 0.04774436579015035 0.03455681132339536 5.478590343263139e-08 7.261331172336183 0.08488201453426703 TKDQPDGSSLS(ph)PAQS(ph)PSQSQPPAASSLR ddPTM_A459_Selumetinib_30min_R1 1 TKDQPDGSSLSPAQSPSQSQPPAASSLR 28 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 TKDQPDGS(0.014)S(0.093)LS(0.816)PAQS(0.93)PS(0.124)QS(0.023)QPPAASSLR 92.695 1.4592e-05 9331500.0 798.72 1087.7 715.77 992.81 942.32 932.64 1272.4 1166.3 572.22 910.42 True False 817.3286219614242 960.3515783419884 618.5723654431758 819.4343708518348 857.0873223801088 923.2584883693665 1176.4218435848836 1135.365935323684 971.0155467047663 1027.281275241775 0.7956230115934534 0.9348477398422022 0.602145079786052 0.7976728385893899 0.8343258492455143 0.8987397226256985 1.1451798761814362 1.1052142803405727 0.9452285076219595 1.0 10.004615538214006 -6.97475728271237 2.81593351264401 1.05683527734619 0.7890913723227674 0.6262789564304874 0.09261877986906136 0.1759803516895803 2.838046971337687 0.037674748102238656 0.030846162437727438 1.0598458833985596e-07 6.97475728271237 -0.2677439050234226 TKDQPDGSSLS(ph)PAQS(ph)PSQSQPPAASSLR ddPTM_A459_Selumetinib_30min_R2 3 TKDQPDGSSLSPAQSPSQSQPPAASSLR 28 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 TKDQPDGS(0.032)S(0.227)LS(0.769)PAQS(0.802)PS(0.122)QS(0.047)QPPAASSLR;TKDQPDGSS(0.001)LS(0.999)PAQS(0.925)PS(0.067)QS(0.008)QPPAASSLR;TKDQPDGS(0.005)S(0.021)LS(0.873)PAQS(0.904)PS(0.123)QS(0.073)QPPAAS(0.001)S(0.001)LR 115.3 8.3917e-12 59869000.0 55203.9 48758.3 56789.8 65871.0 68168.0 53470.2 60093.0 67914.0 57232.1 62801.4 True False 52135.8882367209 52497.90482735504 53136.00609605909 56899.25616618696 59604.126410347846 60835.23469585178 62887.4435720205 68111.61849623204 68680.11919848419 60988.16040436689 0.8548526122291081 0.8607884625356903 0.8712511697967927 0.9329557702500049 0.9773065135127449 0.9974925344935611 1.031141834006156 1.1168006715505898 1.1261221644187605 1.0 15.896241579868354 -6.501234887613714 0.798188501557583 1.086728944828002 0.8486615854056332 0.8510012974951563 0.03604736886287319 0.2288404909460648 0.32325074096925754 0.022187784382234104 0.028453500446923723 3.153298704532802e-07 6.501234887613714 -0.23806735942236879 TKDQPDGSSLS(ph)PAQS(ph)PSQSQPPAASSLREPGLESK ddPTM_A459_Selumetinib_30min_R2 2 TKDQPDGSSLSPAQSPSQSQPPAASSLREPGLESK 35 2 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 2 TKDQPDGS(0.008)S(0.047)LS(0.76)PAQS(0.743)PS(0.315)QS(0.113)QPPAAS(0.006)S(0.006)LREPGLES(0.002)K;TKDQPDGS(0.002)S(0.012)LS(0.965)PAQS(0.771)PS(0.222)QS(0.026)QPPAAS(0.002)S(0.001)LREPGLESK 74.568 1.8673e-05 27077000.0 137227.0 152488.0 141866.0 161341.0 156207.0 109056.0 101125.0 103566.0 70508.0 171750.0 True False 129600.47270320587 164183.33927380014 132738.4960120222 139366.07747125108 136582.88015170177 124077.4740881989 105827.512875386 103867.3599137258 84611.57015812302 166791.1312399092 0.7770225655271262 0.9843649242815071 0.7958366552541313 0.8355724698023035 0.8188857473197633 0.7439093024060626 0.6344912471584937 0.6227391057401305 0.5072905827134139 1.0 17.347683053049323 -6.875801313125119 2.1074878734875453 0.6599583274151762 0.8525817507742712 0.2208621314343664 0.1297171728237014 0.3840904199019121 3.487215087654216 0.05102356897771879 0.04346197285926983 1.3310632313950316e-07 6.875801313125119 0.192623423359095 TKDQPDGSSLS(ph)PAQSPSQSQPPAASSLR ddPTM_A459_Selumetinib_30min_R1 3 TKDQPDGSSLSPAQSPSQSQPPAASSLR 28 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 TKDQPDGSS(0.001)LS(0.998)PAQS(0.001)PSQSQPPAASSLR;TKDQPDGS(0.003)S(0.024)LS(0.963)PAQS(0.009)PS(0.001)QSQPPAASSLR;TKDQPDGSS(0.002)LS(0.99)PAQS(0.007)PS(0.001)QSQPPAASSLR 135.06 1.3296e-12 44866800.0 3503.8799999999997 4681.47 3814.37 4438.03 4060.5999999999995 4132.9400000000005 4715.77 4359.25 2479.21 3857.8199999999997 True False 3585.5135866363603 4133.361316043641 3296.3995048346374 3663.011372640854 3693.319446957159 4091.3663760092763 4360.055672211789 4243.628529160392 4207.038295665873 4353.0087753489815 0.8236862757872362 0.9495412321359882 0.7572692073358764 0.841489544745333 0.8484521023418027 0.9398938957299185 1.001618856571738 0.9748724958221981 0.9664667619073647 1.0 12.08779721315907 -6.868906543362832 3.0798088619678885 0.9830112748230211 0.8439033935868226 0.6926504848116608 0.04490417577016236 0.1510873632200643 2.8662378958610795 0.0169843010381559 0.014882778246113402 1.3523635495112644e-07 6.868906543362832 -0.13910788123619844 TKDQPDGSSLS(ph)PAQSPSQSQPPAASSLR ddPTM_A459_Selumetinib_30min_R2 4 TKDQPDGSSLSPAQSPSQSQPPAASSLR 28 1 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 TKDQPDGS(0.002)S(0.008)LS(0.99)PAQSPSQSQPPAASSLR;TKDQPDGS(0.001)S(0.003)LS(0.995)PAQS(0.001)PSQSQPPAASSLR;TKDQPDGS(0.027)S(0.268)LS(0.702)PAQS(0.003)PSQSQPPAASSLR;TKDQPDGSSLS(1)PAQSPSQSQPPAASSLR 136.94 1.085e-12 95988000.0 186674.0 175874.0 204847.0 208571.0 224626.0 168530.0 211260.0 236136.0 194657.0 187116.0 True False 176299.40639523024 189362.9702759583 191667.36704054973 180163.26999495612 196406.47369808095 191743.47773698036 221084.0086037481 236823.11666558098 233593.83917101243 181713.47489424585 0.9702054649377736 1.0420964674533042 1.0547779527748113 0.9914689601297211 1.0808580586133536 1.0551968028159266 1.2166627088740405 1.3032776837458422 1.2855064232686104 1.0 17.47130588048269 -7.23314124861954 3.613878472446062 1.2292258947075585 1.0313446558413328 0.48687185999054894 0.08345834702619827 0.17566962584249665 4.928505277881847 0.033635908676139435 0.024053093038344357 5.845999197178347e-08 7.23314124861954 -0.19788123886622566 TKDQPDGSSLS(ph)PAQSPSQSQPPAASSLREPGLESK ddPTM_A459_Selumetinib_30min_R1 1 TKDQPDGSSLSPAQSPSQSQPPAASSLREPGLESK 35 2 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 T(0.001)KDQPDGS(0.003)S(0.019)LS(0.976)PAQSPSQSQPPAASSLREPGLESK 88.59200000000001 3.0434e-09 7534900.0 1181.2 1209.3 1688.6 1492.6 1462.9 1523.3 1306.9 1292.2 865.83 1056.6 True False 1208.7196617848983 1067.7145938116826 1459.297394815858 1231.9454295720714 1330.5809532959718 1507.9769850457371 1208.319480808774 1257.926658342848 1469.2502722788226 1192.2249021555535 1.0138352752064834 0.8955647477931763 1.2240118388547623 1.0333163041173714 1.1160486170774233 1.2648427174430772 1.0134996162419703 1.0551085253029904 1.2323599931710911 1.0 10.219440697155871 -5.251134238166759 24.9884416341161 1.1178706661605249 0.9547000062378623 0.32280409328296733 0.09425877646268542 789.314166679012 1913960.2510904546 0.023161812061887128 0.05979213035765259 5.608745858179679e-06 5.251134238166759 -0.16317065992266255 TKDQPDGSSLS(ph)PAQSPSQSQPPAASSLREPGLESK ddPTM_A459_Selumetinib_30min_R2 3 TKDQPDGSSLSPAQSPSQSQPPAASSLREPGLESK 35 2 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 T(0.001)KDQPDGS(0.003)S(0.032)LS(0.938)PAQS(0.012)PS(0.012)QS(0.003)QPPAASSLREPGLESK;T(0.149)KDQPDGS(0.128)S(0.128)LS(0.564)PAQS(0.015)PS(0.005)QS(0.005)QPPAAS(0.002)S(0.004)LREPGLES(0.001)K;TKDQPDGS(0.001)S(0.01)LS(0.933)PAQS(0.051)PS(0.004)QS(0.001)QPPAASSLREPGLESK 101.22 3.9842e-12 30710500.0 51912.0 57844.0 59394.0 63677.0 57433.0 42040.4 39774.5 44558.0 28279.6 63477.0 True False 49026.9388602011 62280.448802224964 55572.65470329772 55004.08275104807 50217.753082465475 47831.083495245715 41624.093061676576 44687.65640302603 33936.310198043575 61644.2540769473 0.795320498144131 1.0103204221513256 0.9015058343301434 0.8922823963834382 0.8146380199488062 0.7759211983576064 0.6752307037363028 0.7249281716872551 0.5505186283166417 1.0 15.911678805385623 -6.579575238377649 1.5905578448782505 0.7162287582561778 0.9119234403639958 0.274595055658462 0.11594969341697303 0.4139119381344126 2.1484018734967374 0.04454479009561177 0.04681901978655278 2.63284178336833e-07 6.579575238377649 0.19569468210781793 TKDS(ph)GSISLQETR ddPTM_A459_Selumetinib_30min_R1 1 TKDSGSISLQETR 13 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 TKDS(0.97)GS(0.03)ISLQETR 184.0 0.00057943 67592000.0 2119.4 2550.0 3108.0 3226.6 2176.4 2546.7 2550.1 1949.4 1739.0 2129.9 True False 2168.777896365488 2251.444814537162 2685.9506710219653 2663.13488078336 1979.545004274628 2521.082510218591 2357.743903902712 1897.6955794563903 2950.955988465256 2403.293411982881 0.9024191076927632 0.9368164549993779 1.117612463642495 1.1081189119501194 0.8236801192915384 1.0490115346084712 0.9810470465848832 0.7896229274355069 1.2278800306910989 1.0 11.230797078852518 -8.279414407113745 24.99979614336326 1.1139399667494514 0.9713757284976399 0.21166293601337538 0.11531125378396924 1566.7491825530437 2179024.5049971524 0.10923081747188947 0.02842524038593406 5.255155760914339e-09 8.279414407113745 -0.14256423825181153 TKDS(ph)GSISLQETR ddPTM_A459_Selumetinib_30min_R2 3 TKDSGSISLQETR 13 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 TKDS(0.494)GS(0.494)IS(0.012)LQETR;TKDS(0.5)GS(0.5)IS(0.001)LQETR;TKDS(0.479)GS(0.479)IS(0.042)LQETR 189.33 0.00055816 30133000.0 48852.0 46586.0 43979.0 45055.0 50323.0 37486.0 48670.0 42457.0 30672.5 44742.0 True False 46137.00141005058 50158.996402400466 41149.43902071468 38918.431275789844 44000.974846672 42649.356235972526 50933.251437775405 42580.54284086528 36807.85706125588 43450.18220632313 1.0618367764482342 1.154402441035127 0.9470487102980748 0.8957023722244875 1.0126764172756153 0.9815690998360402 1.1722218147652161 0.9799853689605174 0.8471277953789428 1.0 15.407074606476527 -5.264067764514181 24.965877209126123 0.9839696350732848 1.1081196108654212 0.2767863706480649 0.08288892130485155 298.98186441674034 2839935.898383834 0.02270732205000818 0.05099509744874702 5.444176987829818e-06 5.264067764514181 0.12414997579213638 TKETDS(ph)PSTPGKDQR ddPTM_A459_Selumetinib_30min_R1 1 TKETDSPSTPGKDQR 15 2 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 T(0.05)KET(0.122)DS(0.659)PS(0.062)T(0.106)PGKDQR 81.656 0.030373 8337200.0 1244.8 1479.1 1979.4 1652.0 1475.9 1398.5 1349.7 1377.7 750.86 1356.0 True False 1273.8014180408413 1305.9262843850656 1710.6083520659179 1363.509211880653 1342.4051055913092 1384.432359736404 1247.891042350296 1341.1589205997072 1274.1545793553892 1530.055808558518 0.8325195792961979 0.8535154581161276 1.1180038940393293 0.8911499856761629 0.8773569552708037 0.9048247469095212 0.815585310921402 0.876542484985059 0.8327503952655059 1.0 10.579368560627213 -5.979038451863828 24.99925913658307 0.8766653430048248 0.9395654573596832 0.060798141887351 0.08506930944065139 586.7520015630307 699769.7812561928 0.02417664344462893 0.03585612323433269 1.0494495076558305e-06 5.979038451863828 0.06290011435485843 TKEVYELLDS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 2 TKEVYELLDSPGK 13 1 E9PBS1;P22234;P22234-2 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 TKEVYELLDS(1)PGK;TKEVYELLDS(1)PGK 151.8 0.00084452 13988000.0 1614.8700000000001 2243.84 2163.65 2242.0299999999997 1709.52 1477.44 2177.89 1838.58 1087.67 1832.77 True False 1652.4933290099734 1981.1301696670846 1869.8382140787241 1850.501548615483 1554.894217840269 1462.5782950081893 2013.6100038707004 1789.8148858504817 1845.6965497262831 2068.02388219159 0.799068784089061 0.9579822490094168 0.9041666443896004 0.8948163338686459 0.7518744010791928 0.7072347218051567 0.9736879835917444 0.8654710911528372 0.8924928602711806 1.0 11.014037131108177 -8.820825516330085 0.9446343608833461 0.9991740475834837 0.8536574967227635 0.2334662946016498 0.07974444891870952 1.7409878270958055 2.8805201383023125 0.08255022477918823 0.0272067294567739 1.5106869711384055e-09 8.820825516330085 -0.14551655086072024 TKEVYELLDS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 TKEVYELLDSPGK 13 1 E9PBS1;P22234;P22234-2 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 TKEVYELLDS(1)PGK;TKEVYELLDS(1)PGK 110.34 0.0030947 15097000.0 221030.0 232840.0 225550.0 221430.0 216980.0 180736.0 235950.0 224000.0 158912.0 241530.0 True False 208746.03745319514 250698.0793013982 211038.35856027209 191270.85201194463 189721.03257418866 205630.7434419446 246922.1425260554 224651.80291480367 190698.8403722651 234556.40132969557 0.8899609487092145 1.0688178957393435 0.8997339546646343 0.8154578213497222 0.8088503724420392 0.8766793073061661 1.0527196918364141 0.9577730628593254 0.8130191258528745 1.0 17.839575348711705 -9.626164317168078 15.324656164235524 1.0000059229565437 0.9126196661316719 0.0855494084714512 0.08841077980202443 0.0 0.0 0.09172601387483363 0.02224682610722413 2.3650247110069336e-10 9.626164317168078 -0.08738625682487178 TKEVYELLDS(ph)PGKVLLQSK ddPTM_A459_Selumetinib_30min_R1 2 TKEVYELLDSPGKVLLQSK 19 2 E9PBS1;P22234;P22234-2 E9PBS1 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 TKEVYELLDS(0.992)PGKVLLQS(0.008)K;TKEVYELLDS(0.971)PGKVLLQS(0.028)K 66.26100000000001 0.0088728 43185000.0 5537.6 4925.5 12270.1 14392.599999999999 7191.5 7009.9 5882.200000000001 5690.0 4386.1 4107.0 True False 5666.615305706111 4348.820170197173 10603.88781483482 11879.202592562631 6541.03009476245 6939.386770479953 5438.50091821361 5539.08271627519 7442.89135193069 4634.173455567726 1.2227887799275097 0.9384241250124733 2.2881939824878117 2.5633918769894914 1.4114771830354629 1.4974378574765324 1.1735643843196084 1.1952687505946205 1.6060882103988643 1.0 12.178096329469925 -6.499677015073178 24.575793228850998 1.3163790161066031 1.7649926956004223 0.18051786141980108 0.46262886271058934 1235.6533330591767 1308833.0590007065 0.1589551561764258 0.17899566187457633 3.164630321671675e-07 6.499677015073178 0.44861367949381914 TKEYVSNDAAQS(ph)DDEEK ddPTM_A459_Selumetinib_30min_R2 2 TKEYVSNDAAQSDDEEK 17 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 T(0.328)KEY(0.003)VS(0.001)NDAAQS(0.668)DDEEK;TKEYVSNDAAQS(1)DDEEK 118.36 0.00085104 9973200.0 84047.0 68071.0 67305.0 68707.0 56911.0 49961.0 70981.0 67557.0 47366.0 58508.0 True False 79376.00420679846 73291.82681723718 62974.669576143206 59348.98807381408 49761.33138920472 56842.67424919764 74281.75714618326 67753.57968533659 56840.5235166174 56818.722017959735 1.3970043919979163 1.2899238880112525 1.1083436469450623 1.0445322591918655 0.8757911058519716 1.0004215552618436 1.3073464961549761 1.1924516652085289 1.0003837027283151 1.0 15.794078761955351 -5.157642092776071 2.346567709400653 1.0681566644777876 1.3929070868308466 0.5104606982334838 0.11159773605826681 0.3131682486363446 3.1149983069543388 0.03411406871837614 0.14668178513211866 6.955973314382801e-06 5.157642092776071 0.32475042235305907 TKEYVSNDAAQS(ph)DDEEKLQSQPTDTDGGR ddPTM_A459_Selumetinib_30min_R1 4 TKEYVSNDAAQSDDEEKLQSQPTDTDGGR 29 2 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 TKEYVSNDAAQS(0.98)DDEEKLQS(0.017)QPT(0.003)DTDGGR;TKEYVSNDAAQS(1)DDEEKLQSQPTDTDGGR;TKEYVSNDAAQS(1)DDEEKLQSQPTDTDGGR;TKEYVSNDAAQS(0.999)DDEEKLQS(0.001)QPTDTDGGR 155.47 5.293700000000001e-19 93914000.0 10580.0 9947.999999999998 14953.099999999999 15340.4 10026.699999999999 10445.4 10182.1 9257.5 7431.400000000001 8512.4 True False 10826.49341490368 8783.283535300268 12922.551151498881 12661.487114972137 9119.786755357663 10340.328759664377 9414.055999344255 9011.961027402036 12610.543032018802 9605.04945779759 1.1271668576484524 0.9144443840598662 1.3453914223219403 1.3182115480616567 0.9494783754553207 1.076551329079297 0.9801153071316794 0.938252433472472 1.312907662519248 1.0 13.229577327218752 -6.278476476560479 24.989034829330457 1.0383417255399527 1.169677049397518 0.16195878153445498 0.1481587942602011 1638.6202608501872 2403428.2184872213 0.04744235543854809 0.05393559948984084 5.2665174006602e-07 6.278476476560479 0.1313353238575652 TKEYVSNDAAQS(ph)DDEEKLQSQPTDTDGGR ddPTM_A459_Selumetinib_30min_R2 5 TKEYVSNDAAQSDDEEKLQSQPTDTDGGR 29 2 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 T(0.001)KEY(0.001)VS(0.002)NDAAQS(0.667)DDEEKLQS(0.311)QPT(0.013)DT(0.004)DGGR;T(0.001)KEYVSNDAAQS(0.797)DDEEKLQS(0.154)QPT(0.037)DT(0.011)DGGR;TKEYVSNDAAQS(0.992)DDEEKLQS(0.007)QPT(0.001)DTDGGR;TKEYVSNDAAQS(0.995)DDEEKLQS(0.004)QPT(0.001)DTDGGR;TKEYVSNDAAQS(0.999)DDEEKLQS(0.001)QPTDTDGGR 81.94 7.660599999999999e-06 138334600.0 208174.0 211610.0 188126.8 184274.0 165772.4 111107.0 136626.4 128124.8 79165.29999999999 178325.4 True False 196604.5224665492 227839.8065666074 176022.92650497294 159175.56330961952 144946.5890879409 126410.98072107445 142979.79832007553 128497.6219557976 95000.57206329577 173176.68235696765 1.1352828786804563 1.315649448099272 1.0164354929847792 0.9191512456712403 0.8369867531540055 0.7299538194207033 0.8256296192656726 0.7420030237727185 0.5485760020940457 1.0 17.401885163666357 -5.74436104309224 1.271302833453612 0.7589428918246673 1.2421568668960288 0.6874660364733864 0.11705874220196945 0.25682271861262634 0.8174756562072057 0.03916891154159222 0.1022534852247747 1.8015194565903262e-06 5.74436104309224 0.48321397507136143 TKFAS(ph)DDEHDEHDENGATGPVK ddPTM_A459_Selumetinib_30min_R1 2 TKFASDDEHDEHDENGATGPVK 22 1 P05455 P05455 SSB Lupus La protein 1 T(0.29)KFAS(0.702)DDEHDEHDENGAT(0.008)GPVK;T(0.151)KFAS(0.848)DDEHDEHDENGAT(0.001)GPVK 94.49 0.00012695 58980000.0 4848.3 5129.0 5077.1 5478.299999999999 4583.5 4583.8 4646.8 4554.2 2359.09 4067.4 True False 4961.25595685043 4528.494295592587 4387.657706514032 4521.617745427228 4168.923234282648 4537.6911337574 4296.288134839855 4433.407821873548 4003.203428883557 4589.490409831059 1.081003665727903 0.9867096106993026 0.9560228510588702 0.985211285275062 0.9083629906606795 0.9887135016204194 0.9361144160224977 0.965991303168829 0.8722544490578675 1.0 12.16411825877539 -1.5228822412506324 0.9117590734076222 0.9472890666856351 73.70763882081573 0.5343205644341399 0.036594522507528496 692.516713557985 1.4516075234968304 0.011287072695558713 104903.77853979262 0.029999758507899384 1.5228822412506324 72.76034975413009 TKFAS(ph)DDEHDEHDENGATGPVK ddPTM_A459_Selumetinib_30min_R2 2 TKFASDDEHDEHDENGATGPVK 22 1 P05455 P05455 SSB Lupus La protein 1 T(0.306)KFAS(0.648)DDEHDEHDENGAT(0.045)GPVK;T(0.475)KFAS(0.512)DDEHDEHDENGAT(0.013)GPVK 57.71100000000001 0.011404 24144100.0 44679.0 52066.0 49418.0 54207.0 51870.0 39492.8 39246.6 40290.9 27796.1 50608.0 True False 42195.920044208004 56059.294781423254 46238.49968225013 46823.91308770925 45353.62687631653 44932.5747200559 41071.64466566253 40408.13984848245 33356.09668792482 49146.815544624806 0.8585687511308752 1.1406495855366658 0.9408239205298264 0.9527354431579318 0.9228192381078261 0.9142520064043128 0.8356928970986919 0.8221924330334744 0.678703112669382 1.0 15.584810320086527 -6.842894855484985 1.1029452202266126 0.8144777253723025 0.9880938623587571 0.2734881915065035 0.0984907457073138 0.5565510119260219 1.428800827778655 0.05277673445258998 0.04402119100836751 1.43583701343791e-07 6.842894855484985 0.17361613698645462 TKFAS(ph)DDEHDEHDENGATGPVKR ddPTM_A459_Selumetinib_30min_R2 1 TKFASDDEHDEHDENGATGPVKR 23 2 P05455 P05455 SSB Lupus La protein 1 T(0.135)KFAS(0.865)DDEHDEHDENGATGPVKR 48.20399999999999 0.023103 5736500.0 12765.0 21421.0 16340.0 20145.0 13945.0 9489.3 6124.1 3420.0 2806.6 17572.0 True False 12055.57240234372 23063.921820628955 15288.702189646847 17401.216247936667 12193.104430118243 10796.364939711208 6408.882784673938 3429.951633788523 3367.998422956093 17064.65070246101 0.7064646451043444 1.3515613195236835 0.8959282235669762 1.019722967164345 0.7145241143646609 0.6326742415040578 0.37556483847335176 0.20099747094699488 0.19736697115460855 1.0 14.058723263661895 -6.675127889377553 1.4391294277621525 0.3816305304779332 1.0227831665100124 0.4532682824869594 0.2630826330810208 0.312831499716701 1.349415563298863 0.11084528337195602 0.10800465269053063 2.1128667592976527e-07 6.675127889377553 0.6411526360320792 TKFASDDEHDEHDENGAT(ph)GPVK ddPTM_A459_Selumetinib_30min_R1 1 TKFASDDEHDEHDENGATGPVK 22 1 P05455 P05455 SSB Lupus La protein 1 T(0.037)KFAS(0.201)DDEHDEHDENGAT(0.762)GPVK 96.561 0.00027311 12355000.0 2113.5 2893.0 2550.3 1834.3 2087.0 2529.2 2140.3 2221.2 1058.8 1967.5 True False 2162.7404378448887 2554.286215080789 2203.983267795146 1513.9739390754721 1898.2312184897755 2503.758544329862 1978.8554478345845 2162.2865605255643 1796.7062683076556 2220.0477900729234 0.9741864330649601 1.150554608104579 0.992763884475996 0.6819555623285667 0.8550407009154624 1.1277948860045124 0.8913571395549029 0.9739819882231175 0.8093097258274057 1.0 11.116375017885717 -5.526249654400159 24.998877102174184 0.9054313178233129 1.0646927379975568 0.22437663373726335 0.11856209722938683 136.83959460412012 1014808.21498277 0.03298103098502782 0.05748889622837512 2.976804719805563e-06 5.526249654400159 0.15926142017424394 TKFASDDEHDEHDENGAT(ph)GPVK ddPTM_A459_Selumetinib_30min_R2 1 TKFASDDEHDEHDENGATGPVK 22 1 P05455 P05455 SSB Lupus La protein 1 T(0.039)KFAS(0.027)DDEHDEHDENGAT(0.934)GPVK 66.777 0.0085354 17224000.0 12826.0 14020.0 13957.0 15650.0 14279.0 11674.0 10873.0 11125.0 8131.1 13516.0 True False 12113.182266546068 15095.288918594739 13059.021815232614 13518.443002244174 12485.144364120368 13281.987533979174 11378.616044440769 11157.37190815711 9757.547201916295 13125.757961214606 0.9228558306757899 1.1500508361650363 0.9949156348776818 1.0299171325716896 0.9511941634923339 1.0119025181803758 0.8668921122927545 0.85003638960326 0.7433892374633861 1.0 13.680113114732935 -7.285149699084535 3.282283418915851 0.8479080996570267 1.015847825364195 0.42910940326358205 0.08103940956523725 0.2172380960258398 4.860930798701935 0.03455639747255405 0.02336375031599548 5.1862124202850545e-08 7.285149699084535 0.1679397257071682 TKNAPS(ph)LPSR ddPTM_A459_Selumetinib_30min_R1 1 TKNAPSLPSR 10 1 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5 Q9Y2D5-5 AKAP2 A-kinase anchor protein 2 1 TKNAPS(1)LPSR 81.525 0.024684 6451400.0 5325.2 3899.7 5207.9 5224.3 4241.9 4251.9 4345.2 5182.9 1844.7 2181.8 True False 5449.266798964562 3443.121311078653 4500.695784947002 4311.974077256713 3858.2208939682714 4209.129746416314 4017.4380656594085 5045.432655568136 3130.3211684427024 2461.8552825316933 2.2134797433587203 1.398588022419359 1.8281723612602565 1.7515140340915638 1.5672005261010307 1.7097389015034954 1.6318741780499801 2.0494432355014687 1.2715293180123814 1.0 11.265530241728047 -8.47479266983015 5.265815914457441 1.0016448002735658 1.7428812828626088 0.5794575801547661 0.22069715744239976 0.11562367985557484 7.246507587572735 0.19705203184736966 0.051209096151159816 3.351253882801612e-09 8.47479266983015 0.741236482589043 TKPIVKPQT(ph)SPEYGQGINPISR ddPTM_A459_Selumetinib_30min_R2 1 TKPIVKPQTSPEYGQGINPISR 22 2 O95793-2;O95793-3;O95793;A0A087X1A5 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 T(0.007)KPIVKPQT(0.496)S(0.496)PEY(0.001)GQGINPISR 63.93600000000001 0.010172 37775000.0 59504.0 57823.0 65548.0 61169.0 50354.0 45162.0 43206.0 48729.0 40609.0 55218.0 True False 56197.005893385125 62257.83816975066 61330.71304326624 52837.67667758936 44028.080349528434 51382.65556018223 45215.164611064814 48870.79332247976 48731.93471026294 53623.71286640636 1.0479879681847033 1.1610131943838846 1.1437237327460048 0.9853416306555411 0.8210561707880303 0.9582077184433815 0.8431934715842989 0.9113653402596791 0.9087758401151672 1.0 15.710583493470939 -5.925127546992208 4.050297226168426 0.9017277522122782 1.1206728764441996 0.7401388546991683 0.055567373154094706 0.09771268112814335 3.1351880646617754 0.015170878557144512 0.02304504616720406 1.1881532300797262e-06 5.925127546992208 0.21894512423192136 TKPIVKPQTS(ph)PEYGQGINPISR ddPTM_A459_Selumetinib_30min_R1 2 TKPIVKPQTSPEYGQGINPISR 22 2 O95793-2;O95793-3;O95793;A0A087X1A5 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 T(0.001)KPIVKPQT(0.169)S(0.823)PEY(0.006)GQGINPIS(0.001)R;TKPIVKPQT(0.151)S(0.786)PEY(0.062)GQGINPISR 102.07 0.00012222 64262000.0 3128.4700000000003 3968.1800000000003 4230.7 4408.9 3393.33 3280.98 3585.5 3491.0 2025.6899999999998 3202.3 True False 3201.357264057063 3503.5836408431683 3656.19417757163 3638.9683803030316 3086.4039006410685 3247.9763200914886 3315.0428482973894 3398.4073396338654 3437.4479794561157 3613.3463980434694 0.8859812792348146 0.9696229630074397 1.011858198691208 1.007090928861245 0.8541677328008944 0.8988831853625163 0.9174439655418579 0.9405152358140952 0.9513198018649421 1.0 11.819119851855442 -3.902644330523052 13.847473892827633 0.9419508912105721 0.9477336208712578 0.0 0.05162308920035587 0.0 0.0 0.012523586858008702 0.0 0.00012512833607827132 3.902644330523052 0.005782729660685715 TKPIVKPQTS(ph)PEYGQGINPISR ddPTM_A459_Selumetinib_30min_R2 1 TKPIVKPQTSPEYGQGINPISR 22 2 O95793-2;O95793-3;O95793;A0A087X1A5 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 T(0.045)KPIVKPQT(0.201)S(0.751)PEY(0.003)GQGINPISR 57.985 0.0078938 31294000.0 35637.0 37872.0 49156.0 43645.0 45492.0 37777.0 33073.0 37825.0 39911.0 44427.0 True False 33656.43820621414 40776.66062232667 45993.35647700614 37700.47570817551 39776.88825635993 42980.43884453754 34610.96003290623 37935.06448773414 47894.31520651347 43144.277074791426 0.7800904427688071 0.9451232790768415 1.066036090888156 0.8738233263897554 0.9219505100851717 0.996202550109488 0.8022143927202088 0.8792606357031544 1.110096598060683 1.0 15.396881583602902 -8.256248667843051 24.968889943506053 1.0550483024503683 0.9133151260322491 0.32861854257728074 0.08375707976225706 475.29057988193375 2286319.0897545484 0.06125757385154901 0.021592838948229442 5.5430823689345135e-09 8.256248667843051 -0.14173317641811922 TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTS(ph)PIKK ddPTM_A459_Selumetinib_30min_R2 1 TKPLASVTNANTSSTQAAPVAVTTPTVSSGQATPTSPIKK 40 2 O14974-5;O14974-4;O14974-3;O14974-2;O14974;F8VZN8;H0YIS4;A0A3B3ISH4 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 TKPLASVTNANTSSTQAAPVAVT(0.002)T(0.002)PT(0.02)VS(0.014)S(0.014)GQAT(0.086)PT(0.391)S(0.469)PIKK 104.29 7.4769e-18 7953400.0 58258.0 44065.0 51995.0 60653.0 52486.0 51188.0 71545.0 75890.0 55849.0 51381.0 True False 55020.25358525189 47444.64380869313 48649.698307875595 52391.95676773899 45892.23944920664 58238.68236160068 74871.9842637279 76110.82733573411 67020.36055144119 49897.49702612958 1.1026656017723635 0.9508421591537551 0.9749927593041279 1.0499916807511036 0.9197302907834128 1.1671664077880122 1.5005158319769036 1.5253435918013587 1.3431607704960624 1.0 15.606679828006623 -7.024883403264714 4.4845878477075685 1.3835115034093204 1.0001123623325456 0.5516580320778116 0.14349865853310584 0.13372041795231646 6.51612261239181 0.05253414868814894 0.04233731252639991 9.443143660216902e-08 7.024883403264714 -0.38339914107677475 TKPLTPS(ph)IGAK ddPTM_A459_Selumetinib_30min_R2 1 TKPLTPSIGAK 11 1 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61;A0A2R8Y7Y0;A0A2R8YCQ1;A0A2R8YD28 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 T(0.009)KPLT(0.456)PS(0.535)IGAK 64.64 0.045522 25823000.0 196780.0 144180.0 179750.0 179970.0 186060.0 160400.0 179480.0 196790.0 142920.0 168700.0 True False 185843.7553727533 155238.14238823074 168185.0806970025 155457.77553443334 162685.47940249546 182493.64403377246 187826.1756328732 197362.62631966177 171507.99351845117 163829.19266476092 1.1343750912149104 0.9475609313774145 1.026587984481831 0.9489015541481806 0.9930188677386342 1.1139262854527037 1.1464756224320571 1.2046853378782094 1.0468707727163324 1.0 17.321832927631426 -6.766304728475639 23.855561028610936 1.1179397312201917 1.0041324234969018 0.280190283769182 0.0715244588725071 72.4613794132698 355285.8047492163 0.023872201851212763 0.021743209527952247 1.7127551084802924e-07 6.766304728475639 -0.11380730772328995 TKPPRPDS(ph)PATTPNISVK ddPTM_A459_Selumetinib_30min_R1 2 TKPPRPDSPATTPNISVK 18 2 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 T(0.001)KPPRPDS(0.981)PAT(0.015)T(0.004)PNISVK;T(0.003)KPPRPDS(0.483)PAT(0.115)T(0.398)PNIS(0.001)VK 73.98100000000002 0.019 98032000.0 13913.6 16891.3 17980.8 18416.3 16756.9 14670.4 17507.5 15738.8 9174.7 14947.6 True False 14237.759808847248 14913.658743447673 15539.106121464516 15200.238921766144 15241.24135367098 14522.829095657436 16186.895179630887 15321.35589717258 15568.795806424489 16866.27006195376 0.844155806621655 0.8842298082899367 0.9213125406142401 0.9012211274888938 0.9036521588760484 0.8610575451662806 0.9597199096286629 0.9084021446884017 0.9230728400076991 1.0 14.041853339654217 -14.52287874526101 0.09126208438384556 1.3219557459263873 0.8222374332806073 0.6356038858386854 0.025880516130436407 142.2666709549655 0.8964842508104216 8.849873531153511 0.594818202635308 3.000000000133506e-15 14.52287874526101 -0.49971831264578004 TKPPRPDS(ph)PATTPNISVK ddPTM_A459_Selumetinib_30min_R2 1 TKPPRPDSPATTPNISVK 18 2 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 T(0.002)KPPRPDS(0.984)PAT(0.011)T(0.003)PNIS(0.001)VK 74.444 0.018385 37398000.0 36807.0 33587.0 37734.0 40914.0 43452.0 20923.0 30694.0 31811.0 30653.0 34930.0 True False 34761.41429009522 36163.0149007733 35306.235521672796 35341.442619413305 37993.17129419135 23804.95332991658 32121.331819007173 31903.564743405444 36784.45651638036 33921.480140960804 1.0247611291029775 1.066080098819326 1.0408223749364012 1.0418602747448473 1.1200328268787394 0.7017663507310127 0.9469319052566955 0.9405121654724409 1.0844001017503497 1.0 15.04991150185136 TKPPRPDSPAT(ph)TPNISVK ddPTM_A459_Selumetinib_30min_R2 1 TKPPRPDSPATTPNISVK 18 2 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 T(0.005)KPPRPDS(0.089)PAT(0.453)T(0.453)PNISVK 65.23100000000001 0.043675 59221000.0 144130.0 117460.0 132940.0 135730.0 126730.0 84613.0 113620.0 117250.0 85460.0 107920.0 True False 136119.8315981043 126468.80430657191 124386.78513412824 117243.33985268997 110809.04441942522 96267.67270966082 118903.55513375887 117591.17808821765 102554.38795190898 104804.06919016548 1.298802924828394 1.2067165453003172 1.186850721496607 1.1186907222080624 1.0572971572159455 0.9185489977014586 1.1345318559912982 1.122009660472726 0.9785344094400144 1.0 16.67733520740476 -5.641848778196689 1.223861734522 1.0399074749939168 1.2744583630353803 0.6708025456385676 0.0628346392573114 0.35274972699736945 0.9957444948031229 0.02266990291112289 0.07111613280853607 2.281136227804872e-06 5.641848778196689 0.2345508880414635 TKPSDEEMLFIYGHYK ddPTM_A459_Selumetinib_30min_R1 1 TKPSDEEMLFIYGHYK 16 1 B8ZWD1;A0A0A0MTI5;P07108;P07108-3;P07108-2;P07108-6;P07108-4;P07108-5 B8ZWD1 DBI Acyl-CoA-binding protein 0 121.18 0.0012306 12996000.0 6592.6 7029.6 7300.4 6683.0 6937.0 5309.1 6561.4 6311.4 4296.4 5813.2 False True 6746.194753033463 6206.571164027621 6309.045778226755 5515.939505446972 6309.54957482682 5255.695274277111 6066.468315386551 6144.001169683522 7290.677003359472 6559.380845363114 1.0284804179044444 0.9462129597818829 0.9618355645086041 0.8409238059940125 0.961912370019969 0.8012486846212642 0.9248538022723581 0.9366739505645221 1.1114885955300673 1.0 12.679343926718731 -8.15981542496323 6.0771771034432325 1.0544184041535947 0.9204948026092266 0.38953608253925676 0.06529999229045422 0.2186368896847907 10.655139572552452 0.04538090527804859 0.016675218407350534 6.921250613832968e-09 8.15981542496323 -0.1339236015443681 TKPTQAAGPS(ph)SPQKPPT(ph)PEETK ddPTM_A459_Selumetinib_30min_R1 1 TKPTQAAGPSSPQKPPTPEETK 22 2 F5H8D7;P18887 F5H8D7 XRCC1 DNA repair protein XRCC1 2 T(0.036)KPT(0.015)QAAGPS(0.747)S(0.225)PQKPPT(0.915)PEET(0.063)K 57.24800000000001 0.021343 23390000.0 2991.1 3172.2 3059.6 3334.1 2723.8 2983.3 3264.1 3521.1 2775.5 4053.0 True False 3060.786810332554 2800.797349284228 2644.123125179794 2751.862023808284 2477.4327709259483 2953.290710619673 3017.8863090580126 3427.708989855287 4709.820785500473 4573.242029563183 0.6692816147814744 0.6124314722857012 0.578172576060303 0.6017311146051744 0.5417235201878398 0.645776167438433 0.6599008514198993 0.7495140138434108 1.0298647556928746 1.0 12.15900155753771 -8.078654707383073 1.9912840271996268 1.0286160509385103 0.6079883293095735 0.9426790520914476 0.038841173722609805 0.07281736470322088 0.5164024310049059 0.03504712499201491 0.011138547850351798 8.343442794449742e-09 8.078654707383073 -0.4206277216289368 TKPTQAAGPS(ph)SPQKPPTPEETK ddPTM_A459_Selumetinib_30min_R1 2 TKPTQAAGPSSPQKPPTPEETK 22 2 F5H8D7;P18887 F5H8D7 XRCC1 DNA repair protein XRCC1 1 T(0.021)KPT(0.03)QAAGPS(0.442)S(0.442)PQKPPT(0.064)PEETK;TKPTQAAGPS(0.887)S(0.113)PQKPPTPEETK 78.708 0.00054815 181810000.0 4442.9 7001.3 5564.5 6180.799999999999 4875.7 4878.3 4297.0 4998.1 2839.3 5519.7 True False 4546.410925621506 6181.584541183931 4808.871463610591 5101.439307985434 4434.6937958747485 4829.228731142009 3972.8738304654507 4865.5341518831365 4818.08472573284 6228.207261431009 0.7299710389819157 0.9925142632076817 0.7721116625951352 0.8190863106911626 0.7120337538118187 0.7753802223390415 0.6378840111933964 0.7812094151094803 0.7735909425444881 1.0 12.60460123968651 -4.493565177299479 19.286201810844073 0.7944594515714067 0.4929398603815276 0.03297532138716808 0.1071743769074094 31769105.611248154 535833606.8839629 0.026337486601417257 325836397.0390403 3.20948110108694e-05 4.493565177299479 -0.30151959118987914 TKPTQAAGPS(ph)SPQKPPTPEETK ddPTM_A459_Selumetinib_30min_R2 1 TKPTQAAGPSSPQKPPTPEETK 22 2 F5H8D7;P18887 F5H8D7 XRCC1 DNA repair protein XRCC1 1 T(0.001)KPT(0.001)QAAGPS(0.496)S(0.496)PQKPPT(0.006)PEET(0.001)K 50.858 0.019258 158010000.0 59307.0 58173.0 56043.0 61917.0 58692.0 46813.0 53742.0 56141.0 37587.0 60407.0 True False 56010.954364731646 62634.68204432329 52437.254395004755 53483.79778721738 51318.586246862695 53261.06582389644 56241.10948775276 56304.36101535712 45105.450268528 58662.89295376522 0.9547935934369333 1.067705305527438 0.8938743344337422 0.9117142898044645 0.8748049007284572 0.9079174780192617 0.9587169444929834 0.9597951648878454 0.7688923610377956 1.0 15.840160598737352 -5.276677924733981 24.60176528900514 0.9085748241756086 1.0112494517826476 0.2890842934176834 0.0638348189566144 677.3264912232914 1093505.2637499522 0.015962654725802425 0.033444692293449936 5.288372951422252e-06 5.276677924733981 0.10267462760703894 TKPTQAAGPSS(ph)PQKPPTPEETK ddPTM_A459_Selumetinib_30min_R1 2 TKPTQAAGPSSPQKPPTPEETK 22 2 F5H8D7;P18887 F5H8D7 XRCC1 DNA repair protein XRCC1 1 TKPTQAAGPS(0.019)S(0.922)PQKPPT(0.058)PEET(0.001)K;TKPTQAAGPS(0.23)S(0.767)PQKPPT(0.004)PEETK 132.6 2.4141e-05 193498000.0 8508.7 10194.0 10425.4 11015.8 7666.099999999999 8518.7 9107.9 8829.2 5390.1 8536.2 True False 8706.936154951884 9000.481740937968 9009.687942623032 9092.09732217608 6972.702608559887 8433.009612360742 8420.883770187642 8595.02093471651 9146.606022671984 9631.904419629222 0.9039682886810723 0.9344446693839223 0.9354004722328689 0.9439563482011877 0.7239173381278529 0.8755287890082042 0.8742698643298832 0.8923490682902118 0.9496155302404964 1.0 13.233605360521008 -8.448094274796807 2.2724638880884442 0.9992878091794244 0.8838820533637064 0.2864605843378428 0.05916719924120514 0.4002333422811446 4.448342299439799 0.060657191053454226 0.016783872394215294 3.5637376492976575e-09 8.448094274796807 -0.11540575581571799 TKPTQAAGPSS(ph)PQKPPTPEETK ddPTM_A459_Selumetinib_30min_R2 2 TKPTQAAGPSSPQKPPTPEETK 22 2 F5H8D7;P18887 F5H8D7 XRCC1 DNA repair protein XRCC1 1 T(0.001)KPT(0.003)QAAGPS(0.184)S(0.772)PQKPPT(0.04)PEET(0.001)K;TKPT(0.006)QAAGPS(0.205)S(0.772)PQKPPT(0.016)PEET(0.002)K 94.707 0.00025695 178748000.0 352974.0 319088.0 307945.0 333483.0 277027.0 244026.0 286116.0 292829.0 213163.0 305831.0 True False 333357.1181468764 343561.02357036795 288132.1539651656 288062.04010973766 242224.39160719723 277638.3664525269 299420.9609280981 293681.0839095497 255801.5562718551 297000.86438563396 1.1224112725612694 1.1567677564880048 0.9701391090601239 0.9699030361598885 0.8155679684914537 0.9348065940038266 1.0081484494917896 0.9888223204907115 0.8612821945855196 1.0 18.18010760426101 -5.333562980734847 3.8019752891712844 0.9387062786072908 1.1416197103585164 0.643919755953507 0.05849540704338214 0.13808967511713893 3.8501590991488337 0.01626988142523258 0.03854713948768882 4.639135090619818e-06 5.333562980734847 0.20291343175122556 TKS(ph)PTDDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R1 2 TKSPTDDEVTPSAVVR 16 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 T(0.094)KS(0.733)PT(0.171)DDEVT(0.001)PSAVVR;T(0.202)KS(0.649)PT(0.149)DDEVT(0.001)PSAVVR 158.45 0.00032679 79597000.0 3224.1 3716.1000000000004 3390.5 4310.9 3428.2 3345.6000000000004 3519.4 3521.6 1859.0900000000001 3108.1 True False 3299.2152569934765 3281.0172844319795 2930.0887226833884 3558.082240615194 3118.1199152978684 3311.946301561754 3253.928824514805 3428.1957282310573 3154.739947438686 3507.054910457766 0.9407366982351695 0.9355477368341854 0.835484130558119 1.0145499091004446 0.8890992570432463 0.9443668223402454 0.9278237460188723 0.9775141295930222 0.8995410759128681 1.0 11.776044303911192 -14.522878599344658 0.19821291776077576 1.312752971672799 0.9186303594163792 0.16811294146365086 0.046309164222862464 244.17309407465376 2.4047449140582944 30.24031887424709 0.10741464515156346 3.0000010080881314e-15 14.522878599344658 -0.39412261225641987 TKS(ph)TGGAPTFNVTVTK ddPTM_A459_Selumetinib_30min_R1 1 TKSTGGAPTFNVTVTK 16 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 T(0.081)KS(0.706)T(0.169)GGAPT(0.045)FNVTVTK 109.87 0.013739 8325300.0 626.19 912.56 769.96 843.46 598.46 820.51 636.21 748.9 392.42 568.88 True False 640.779008646365 805.717050962366 665.4036610875389 696.1655447051177 544.3293986666944 812.256414363473 588.2201674843908 729.0367392299639 665.9080787771913 641.9012893604499 0.9982516303788654 1.2552039765570993 1.0366136851828187 1.0845367601593903 0.8479954904110412 1.2653914672344002 0.9163716871023212 1.13574587138831 1.0373995033421108 1.0 9.326207648649794 TKSDES(ph)GEEKNGDEDCQR ddPTM_A459_Selumetinib_30min_R1 3 TKSDESGEEKNGDEDCQR 18 2 Q6PKG0;Q6PKG0-3;A0A0B4J210;E5RH50;H0YBM7;E5RHK4 Q6PKG0 LARP1 La-related protein 1 1 T(0.003)KS(0.001)DES(0.996)GEEKNGDEDCQR;T(0.031)KS(0.093)DES(0.876)GEEKNGDEDCQR;T(0.04)KS(0.04)DES(0.92)GEEKNGDEDCQR 123.43 0.0010035 47526700.0 3054.27 3308.0599999999995 5119.9400000000005 4806.709999999999 2952.26 3881.6 3019.11 3133.45 2072.57 2802.04 True False 3125.428548425129 2920.750797324627 4424.680269817307 3967.308331621578 2685.228604263838 3842.5546282108144 2791.3761020005954 3050.340727119949 3516.9999154763887 3161.7091281809076 0.9885250102761184 0.9237885836149272 1.3994583595243788 1.2547986455364326 0.8492965340580798 1.21534096668204 0.882869356045607 0.964775886539242 1.1123730150027742 1.0 11.62648893299297 -6.248994306118663 24.970843212984526 1.0068476677574176 1.1444970424810057 0.15512610501423796 0.15710703408574617 1592.471574468289 3195268.8527207784 0.048427018591280784 0.06207247189909951 5.636450455283368e-07 6.248994306118663 0.13764937472358807 TKSNS(ph)LSEQLAINTSPDAVK ddPTM_A459_Selumetinib_30min_R1 1 TKSNSLSEQLAINTSPDAVK 20 1 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 T(0.258)KS(0.258)NS(0.338)LS(0.145)EQLAINTSPDAVK 57.735 0.020681 12147000.0 1314.7 1512.0 3137.0 3115.4 1857.2 1883.5 1809.6 1666.8 1194.7 1324.2 True False 1345.329952039119 1334.9743370902695 2711.01263030756 2571.3538733008363 1689.2165879152915 1864.5537000811692 1673.1004150826816 1622.5910494705608 2027.3186425643714 1494.1739688002879 0.900383743881792 0.8934530817466697 1.814388877678216 1.7209200046266666 1.1305354150103475 1.2478826020361398 1.1197494067080145 1.085945200058185 1.3568156619621474 1.0 10.545132417604277 TKSNS(ph)LSEQLAINTSPDAVK ddPTM_A459_Selumetinib_30min_R2 2 TKSNSLSEQLAINTSPDAVK 20 1 Q5T1M5;Q5T1M5-2;Q5T1M5-3 Q5T1M5 FKBP15 FK506-binding protein 15 1 T(0.392)KS(0.095)NS(0.512)LS(0.001)EQLAINTSPDAVK;T(0.227)KS(0.227)NS(0.334)LS(0.213)EQLAINTSPDAVK 134.69 6.5044e-05 7740600.0 94909.0 81376.0 94132.0 101027.0 97351.0 63232.0 75611.0 88415.0 54568.0 78499.0 True False 89634.33773082959 87617.27753491903 88075.64960317226 87266.94831870432 85120.89705101779 71941.63403705417 79127.06132035423 88672.2730121089 65483.12475731065 76232.52990510379 1.1758016930883537 1.149342382365996 1.1553551969587144 1.1447468479314076 1.1165954633406299 0.9437130595902952 1.0379697672221246 1.1631815594010906 0.8589918875685449 1.0 16.218119134725008 -6.596036334740715 6.007077119354997 1.013677382545914 1.1528937193242723 0.5099503939327077 0.07254936823389066 0.186654030684826 11.617855086723981 0.02362074548332513 0.023645458087868977 2.534916540793478e-07 6.596036334740715 0.13921633677835832 TKSPPAS(ph)SAASADQHSQSGSSSDNTER ddPTM_A459_Selumetinib_30min_R1 1 TKSPPASSAASADQHSQSGSSSDNTER 27 1 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 T(0.011)KS(0.028)PPAS(0.469)S(0.469)AAS(0.02)ADQHS(0.002)QSGSSSDNTER 70.027 0.00037676 2907700.0 432.04 531.64 349.14 690.04 574.0 388.06 423.68 453.11 272.69 228.02 True False 442.10569139650164 469.39534164726905 301.7287056887416 569.5374676550393 522.0818013479308 384.15646873028896 391.72147649327485 441.0920508912924 462.73501351040284 257.288588102886 1.7183260814494807 1.824392387973168 1.1727247909187664 2.2136134052991476 2.029168122836283 1.4930956384924088 1.5224984496266545 1.7143863789050215 1.7985057826403157 1.0 8.00724365830197 -10.753093060689032 4.153666350862726 0.9995491084216924 1.7185297732080616 0.38512113264379044 0.2731988578346646 100298518.21305157 353.6331335271627 437472.21273898537 0.0674196917505335 1.7656594343694525e-11 10.753093060689032 0.7189806647863691 TKSPPASSAAS(ph)ADQHSQSGSSSDNTER ddPTM_A459_Selumetinib_30min_R2 1 TKSPPASSAASADQHSQSGSSSDNTER 27 1 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 T(0.02)KS(0.02)PPAS(0.195)S(0.195)AAS(0.568)ADQHS(0.001)QSGSSSDNTER 47.577 0.024378 1678000.0 1243.9 709.34 2646.1 3632.2 3145.3 2074.0 2085.5 3242.2 1830.1 2871.2 True False 1174.7690177262325 763.7440971124108 2475.8528068558458 3137.4880941055126 2750.1592946612345 2359.6746741025195 2182.479882339851 3251.6342652248954 2196.171137266423 2788.3009957264985 0.4213207324197593 0.2739102049179649 0.8879431634714015 1.1252329281932607 0.9863208092943617 0.8462768824883271 0.7827275052746594 1.1661704637370667 0.7876377552611408 1.0 11.445170592497847 -5.303680861957324 5.746140008863492 0.9546432686930714 0.34658557795580897 0.7831724602464218 0.12644407534458446 0.07520778689647628 6.641155633744124 0.03289168464272568 0.07214427412848483 4.969573727043098e-06 5.303680861957324 -0.6080576907372623 down TKSPPASSAASADQHSQSGS(ph)SSDNTER ddPTM_A459_Selumetinib_30min_R1 2 TKSPPASSAASADQHSQSGSSSDNTER 27 1 Q8IY57-3;Q8IY57;Q8IY57-5 Q8IY57-3 YAF2 YY1-associated factor 2 1 TKSPPASSAASADQHS(0.001)QS(0.185)GS(0.468)S(0.172)S(0.172)DNT(0.002)ER;TKSPPASSAASADQHS(0.001)QS(0.177)GS(0.607)S(0.177)S(0.038)DNTER 101.74 3.44e-07 3564600.0 1656.7399999999998 2095.2 2809.8 2895.3999999999996 3324.0 2290.6 2645.8999999999996 1883.4099999999999 808.48 1347.67 True False 1695.3388185451352 1849.893009967945 2428.2445931266134 2389.7727433893706 3023.3447868998655 2267.558643698396 2446.317632773689 1833.4558486221188 1371.9315109570969 1520.656571917447 1.1148729107239679 1.2165093974080898 1.5968395744114385 1.5715400752031905 1.9881838166047106 1.49117077818508 1.608724598276023 1.2057001445831077 0.9021968117542689 1.0 10.570478653414538 -7.971020318478381 3.4809916825595875 0.964069913243638 1.5234307628808599 0.5066021927678048 0.2240364607586668 0.21129676111817317 5.2824318910556345 0.1675682216932584 0.06633566893933235 1.0690048646329214e-08 7.971020318478381 0.5593608496372219 TKSPT(ph)DDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R1 1 TKSPTDDEVTPSAVVR 16 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 T(0.001)KS(0.181)PT(0.744)DDEVT(0.07)PS(0.004)AVVR 157.74 0.00076752 52606000.0 6223.0 7538.2 8413.6 8456.7 7292.9 6395.3 7462.5 6732.5 3938.8 6581.3 True False 6367.983792149872 6655.624039585898 7271.079332596657 6979.896096919559 6633.258482666072 6330.969088467803 6899.597616906779 6553.932229757952 6683.855921430106 7426.073962290692 0.8575168823373212 0.8962507070873373 0.9791283213066431 0.939917395431717 0.8932389464944054 0.8525324580143171 0.9291043493429585 0.8825568211464845 0.9000524308497949 1.0 12.85838396889576 -10.109361484800079 8.593094624106087 0.9999999083423413 0.9048124004416813 0.39136631533321764 0.0361117564115909 0.0 0.0 0.037255691199009455 0.009035832351112369 7.773892221355449e-11 10.109361484800079 -0.09518750790066 TKSPT(ph)DDEVTPSAVVR ddPTM_A459_Selumetinib_30min_R2 1 TKSPTDDEVTPSAVVR 16 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 T(0.06)KS(0.29)PT(0.65)DDEVTPSAVVR 149.31 0.0027261 61748000.0 118850.0 100360.0 104660.0 107240.0 106400.0 87756.0 101380.0 106590.0 81515.0 99402.0 True False 112244.79279424604 108057.28929173833 97926.28954519195 92633.72700068163 93033.08077193127 99843.59243034745 106094.37088065903 106900.15925307556 97820.27771939932 96532.0059825878 1.1627728197681138 1.1193933886676863 1.014443743796805 0.9596167204625444 0.9637537293974016 1.0343055799374663 1.0990590095040196 1.1074063795209843 1.013345539893203 1.0 16.55871973868335 -5.12852668568725 3.6624453210107437 1.0265177110725467 1.1548077074967358 0.5121879971579475 0.0463973535700068 0.22302163345604786 5.227933219523457 0.014081810832122456 0.04589485391886996 7.438293561158757e-06 5.12852668568725 0.12828999642418903 TKSVS(ph)SMSEFESLLDCSPYLAGGDAR ddPTM_A459_Selumetinib_30min_R1 2 TKSVSSMSEFESLLDCSPYLAGGDAR 26 1 O94964-2;H0YDM2;O94964;O94964-3;X6R3R3;O94964-4 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 T(0.212)KS(0.212)VS(0.275)S(0.093)MS(0.12)EFES(0.088)LLDCSPYLAGGDAR;T(0.241)KS(0.164)VS(0.311)S(0.114)MS(0.042)EFES(0.127)LLDCSPYLAGGDAR 100.67 9.8001e-07 53393000.0 4585.0 5388.0 6511.9 8150.9 6431.7 5916.6 5922.0 5742.0 3273.7999999999997 4854.1 True False 4691.821579143044 4757.170455186753 5627.619747306286 6727.498326342619 5849.953870608865 5857.084375842983 5475.298772170446 5589.703507355387 5555.399491108425 5477.171017937984 0.856614037388483 0.8685451740701182 1.0274683278786758 1.2282797641902647 1.0680612037582906 1.0693630629134576 0.9996581728484638 1.0205457322856732 1.0142826420636197 1.0 12.419215212112547 -5.290246362118909 4.505658893563576 1.0610422665181636 0.8593931721516311 0.5962258704920548 0.06304580731087064 0.13152304635245268 6.683581189245614 0.01790582863516082 0.04249817716780281 5.125705357486445e-06 5.290246362118909 -0.20164909436653244 TKVGDGDLS(ph)AEEIPENEVSLR ddPTM_A459_Selumetinib_30min_R1 1 TKVGDGDLSAEEIPENEVSLR 21 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 T(0.001)KVGDGDLS(0.999)AEEIPENEVSLR 88.829 0.00046966 12060000.0 3087.3 2674.1 3873.2 4043.2 2997.8 3226.8 2733.1 2819.8 1463.8 2209.3 True False 3159.2280831599387 2361.0151288446386 3347.2407139646925 3337.131020263833 2726.649519304578 3194.3413216999843 2526.940066568567 2745.009743998733 2483.961688277999 2492.885175404377 1.2672978740978202 0.9471014357737726 1.342717565570074 1.3386621466520248 1.0937726078226935 1.281383255521114 1.013660834241459 1.1011376581167474 0.9964204179099704 1.0 11.283600717154648 -7.272742167232679 24.633504195676924 1.0362328517855846 1.2061390190686927 0.3779625274672188 0.115310384955526 747.4238623797235 1628941.849196723 0.04832469236812869 0.03292768438791183 5.3365162076224654e-08 7.272742167232679 0.16990616728310814 TLAAS(ph)ASALR ddPTM_A459_Selumetinib_30min_R2 1 TLAASASALR 10 0 H0YG09 H0YG09 LATS1 1 TLAAS(0.874)AS(0.126)ALR 93.162 0.025607 3161600.0 13768.0 14714.0 14893.0 12402.0 14882.0 12470.0 9381.7 10854.0 10691.0 14477.0 True False 13002.829677670856 15842.516487033034 13934.80059427236 10712.826205356689 13012.390113231972 14187.629308610616 9817.967639485878 10885.583343023563 12829.498731498468 14059.011394236752 0.9248751077192484 1.12685849970414 0.9911650402378 0.7619900080419756 0.9255551296136068 1.0091484323304973 0.6983398308867282 0.7742780084441727 0.9125462930315071 1.0 13.77920752966567 -5.592029234990514 7.321409413998426 0.8609915842673107 1.034020283800502 0.28414495109794435 0.10604135786965463 0.24966528409620972 22.068169160215607 0.029030455161134377 0.05059966599088507 2.5584136587985002e-06 5.592029234990514 0.17302869953319122 TLAQLNPESSLFIIAS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 TLAQLNPESSLFIIASK 17 0 P06744-2;P06744;A0A2U3TZU2;K7EQ48;A0A0J9YXP8;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YX90 P06744-2 GPI Glucose-6-phosphate isomerase 1 TLAQLNPESSLFIIAS(1)K 117.55 0.001579 4881600.0 570.74 646.02 851.42 778.1 683.89 614.9 729.74 847.92 382.53 1015.4 True False 584.0371315332821 570.3836780734498 735.8018405152893 642.2194417459659 622.0322702505858 608.7146642845296 674.6951242829552 825.430407167673 649.125471114212 1145.736480833569 0.5097482198597463 0.4978314713855257 0.6422086167492582 0.5605298011273288 0.542910416711208 0.5312867962811705 0.588874610846019 0.7204365235600594 0.5665573907901993 1.0 10.16205954733313 -14.522878745280336 0.21017179005237024 3.062951938256057 0.5149392174052235 0.8456799729277398 0.05598136222553055 53.55307626774139 0.5324070276704094 46.45747795380245 0.12010743599702182 3.0000000000000132e-15 14.522878745280336 -2.548012720850833 TLDFDPLLS(ph)PASPK ddPTM_A459_Selumetinib_30min_R1 1 TLDFDPLLSPASPK 14 0 Q53H80 Q53H80 AKIRIN2 Akirin-2 1 TLDFDPLLS(0.953)PAS(0.047)PK 157.23 0.00031485 49827000.0 6400.4 8028.8 9033.2 9421.7 5870.2 6902.3 6625.3 6223.2 5044.4 7385.3 True False 6549.5168669895575 7088.784363512145 7806.541055815833 7776.376962213037 5339.241446467986 6832.8691287869715 6125.548286940368 6058.1405201975 8559.978371600999 8333.275193913885 0.7859475073825624 0.850660058447291 0.9367914624393123 0.933171745953191 0.640713443661076 0.8199500160245855 0.7350709228244489 0.7269819343806138 1.0272045711214102 1.0 13.02466790838629 -8.27306590052813 24.796045515103284 1.013602343857799 0.8068072976167796 0.4847610803743472 0.0865275686573442 703.1144928900596 1499524.3943779054 0.08674816532105216 0.02317174464924393 5.332539725511175e-09 8.27306590052813 -0.2067950462410194 TLDFDPLLS(ph)PASPK ddPTM_A459_Selumetinib_30min_R2 2 TLDFDPLLSPASPK 14 0 Q53H80 Q53H80 AKIRIN2 Akirin-2 1 TLDFDPLLS(0.813)PAS(0.187)PK;TLDFDPLLS(0.643)PAS(0.356)PK 121.42 0.0019233 4142300.0 43303.0 41237.0 36387.0 42375.0 39312.0 35217.0 38076.0 39373.0 28787.0 41185.0 True False 40896.39261564357 44399.74530214632 34045.90003517008 36603.451899047715 34373.275106260924 40067.82208190377 39846.609446162634 39487.56891144897 34545.204375984125 39995.88203851904 1.022515082334158 1.1101079170947157 0.8512351347166521 0.9151805144288564 0.8594203541543821 1.0017986862576362 0.9962678009647932 0.9872908634298769 0.8637190284418405 1.0 15.287563847838541 -5.250453520142595 24.998315202457036 0.9351676905447965 1.066311505374431 0.428036257431723 0.061004885104232576 706.6794493122558 1608041.5609552802 0.015971318780209 0.041364646339163216 5.617543962437583e-06 5.250453520142595 0.13114381482963444 TLDFDPLLSPAS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 TLDFDPLLSPASPK 14 0 Q53H80 Q53H80 AKIRIN2 Akirin-2 1 TLDFDPLLS(0.126)PAS(0.874)PK 181.75 1.0973e-11 0.0 71268.0 67581.0 76242.0 56796.0 70051.0 54574.0 64311.0 50888.0 47708.0 57343.0 True False 67307.20986840832 72764.24539283523 71336.67272601323 49060.286821435126 61250.567116114304 62091.07312655301 67301.5889298289 51036.07565503812 57250.933072895794 55687.3585949933 1.208662281109877 1.3066564338603281 1.2810209448940701 0.8809950419491795 1.0999007433909997 1.114994043408183 1.2085613436849167 0.9164750662033849 1.0280777274654769 1.0 15.765062242802443 -5.732516696531703 24.982118754871898 1.045289283376379 1.2695677736323918 0.5628074962068828 0.09254634293753283 162.49088653063143 140351.15469477547 0.02587316187388558 0.044804071720463585 1.8513277182004642e-06 5.732516696531703 0.22427849025601287 TLDFDPLLSPAS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 2 TLDFDPLLSPASPKR 15 1 Q53H80 Q53H80 AKIRIN2 Akirin-2 1 TLDFDPLLS(0.006)PAS(0.994)PKR;TLDFDPLLS(0.001)PAS(0.999)PKR 108.47 0.0020461 51993000.0 10757.9 11974.0 14866.4 16568.7 12418.3 12343.2 11693.2 11573.5 6969.5 9924.2 True False 11008.538138770538 10572.07851343842 12847.624535289871 13675.287578018742 11295.066957628944 12219.038614728901 10811.172509750668 11266.533183973805 11826.732467860033 11198.067739894133 0.9830747941943253 0.9440984604669278 1.147307270656976 1.2212185080198514 1.0086621388607289 1.0911738434299219 0.9654498223148699 1.0061140408925868 1.056140464816642 1.0 13.450962191960157 TLDFDPLLSPAS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 TLDFDPLLSPASPKR 15 1 Q53H80 Q53H80 AKIRIN2 Akirin-2 1 TLDFDPLLS(0.017)PAS(0.983)PKR 68.26100000000001 0.029752 6648600.0 74047.0 68045.0 75725.0 76521.0 66235.0 52587.0 47499.0 50986.0 37382.0 61085.0 True False 69931.76417362673 73263.83270084012 70852.93594314618 66098.70779391215 57913.96715158718 59830.381912743076 49707.7976174829 51134.3608188133 44859.44454034944 59321.317332109684 1.1788639787298483 1.2350338123928273 1.194392490417515 1.114248819254288 0.9762758103862821 1.0085814780171418 0.8379415672648399 0.8619896374272707 0.7562111995794762 1.0 15.856263015228029 -6.429963772341197 0.9723129726041754 0.8525001643708712 1.2210538759569394 0.819240371072478 0.06597208532021022 0.20498925553853484 0.41728500033085125 0.03204992872706123 0.04174981129850577 3.715662228433091e-07 6.429963772341197 0.3685537115860682 TLDKVS(ph)LEETAQLPSAPQGSR ddPTM_A459_Selumetinib_30min_R2 1 TLDKVSLEETAQLPSAPQGSR 21 1 Q9BRP8-2;Q9BRP8 Q9BRP8-2 WIBG Partner of Y14 and mago 1 T(0.082)LDKVS(0.915)LEET(0.002)AQLPSAPQGSR 52.393 0.025723000000000003 7155300.0 16848.0 19882.0 19950.0 17600.0 17934.0 14085.0 14865.0 16943.0 10375.0 12930.0 True False 15911.655607887742 21406.885469293924 18666.43871991765 15202.849638306541 15680.97058800578 16025.08089910029 15556.251954438705 16992.30132493536 12450.28990172076 12556.677303825454 1.2671867901741949 1.7048208655304227 1.4865746939463695 1.2107382606443917 1.2488152883588475 1.276219855886411 1.2388828332555313 1.3532482291122168 0.9915274240525173 1.0 13.61616713426675 -6.472882633791613 0.21835037405299743 0.9457718287429423 1.699329008550111 0.4970204874677695 0.1414369188664708 4.707286312701318 0.4425606284893672 0.3531168833128378 1.0539731173123164 3.3660252246329396e-07 6.472882633791613 0.7535571798071686 TLDS(ph)DEERPR ddPTM_A459_Selumetinib_30min_R2 1 TLDSDEERPR 10 1 Q9BW71;Q9BW71-2 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 T(0.03)LDS(0.97)DEERPR 101.56 0.008926700000000001 18925000.0 32957.0 24118.0 21930.0 31434.0 32965.0 32543.0 28755.0 37983.0 38863.0 26289.0 True False 31125.381877324107 25967.773048407144 20519.047675578662 27152.634973325457 28823.641989160864 37025.50285405894 30092.164476951548 38093.52424157586 46636.68592294689 25529.968262975053 1.2191704101122534 1.0171486615620677 0.8037239789810667 1.0635592921086268 1.1290120572128746 1.45027610190003 1.1786996429836083 1.4921101291309147 1.826742808395181 1.0 14.639904123840624 -6.61267652827427 2.255666865978926 1.4139932682343201 1.007870558420805 0.3709442847221317 0.22327187736455348 0.31516828479949455 3.264441053058828 0.08297759361983689 0.08420012275220716 2.4396272278498254e-07 6.61267652827427 -0.40612270981351517 TLDS(ph)DEERPRPAPPDWSHMR ddPTM_A459_Selumetinib_30min_R1 1 TLDSDEERPRPAPPDWSHMR 20 2 Q9BW71;Q9BW71-2 Q9BW71 HIRIP3 HIRA-interacting protein 3 1 T(0.009)LDS(0.991)DEERPRPAPPDWSHMR 61.015 0.010813 11243000.0 1034.6 1016.4 1001.4 1220.4 1009.7 911.21 1056.3 706.68 448.69 833.4 True False 1058.7041670188423 897.3994154884596 865.4153802964593 1007.2800497452473 918.3728132770135 902.0440547124837 976.6224405679908 687.936550779851 761.3941589789966 940.375008003443 1.1258318840976325 0.954299516523491 0.9202875160770869 1.0711471925267917 0.9766027440763835 0.9592386516392628 1.0385457208624744 0.7315555442508446 0.8096707722970546 1.0 9.877092387306055 -7.749168950311419 24.999459566108122 0.8279598555048803 1.0007475265527244 0.4190928900571155 0.08496719416659028 183.32182173202438 373496.9575403862 0.038719014194997 0.022147567705903953 1.7816855169138815e-08 7.749168950311419 0.1727876710478441 TLDSGTSEIVKS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 TLDSGTSEIVKSPR 14 1 Q9H501 Q9H501 ESF1 ESF1 homolog 1 TLDSGTS(0.001)EIVKS(0.999)PR;TLDSGTSEIVKS(1)PR;TLDSGTSEIVKS(1)PR;TLDSGTSEIVKS(1)PR 214.58 5.1128e-06 232340000.0 13945.099999999999 15576.1 18509.7 20856.2 15959.9 15561.0 14676.900000000001 14104.899999999998 9555.1 12365.1 True False 14269.993697558912 13752.442970867556 15996.184406504262 17214.05618936153 14516.329862949202 15404.470468257541 13569.809616560022 13730.792232827767 16214.306823107749 13952.281031273544 1.0227713780688066 0.985677033027212 1.1464924173079214 1.2337807811336965 1.0404269975935379 1.104082582176274 0.972587176687724 0.9841252625323904 1.1621258765333033 1.0 13.768213384291073 -7.231981215647609 24.618866980826045 1.0283866632154814 1.0911850415409843 0.1128786155289544 0.08106305157244753 1370.3361916965998 1145222.4575486348 0.0328579557289315 0.025446993574877303 5.8616351704417675e-08 7.231981215647609 0.06279837832550283 TLDSGTSEIVKS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TLDSGTSEIVKSPR 14 1 Q9H501 Q9H501 ESF1 ESF1 homolog 1 TLDSGTS(0.001)EIVKS(0.999)PR 154.81 0.0015997 50560000.0 22424.0 20497.0 26698.0 22728.0 24790.0 20143.0 18299.0 21098.0 14530.0 22018.0 True False 21177.76385038431 22069.053991757224 24980.279746584543 19632.40719201313 21675.658574588128 22917.5154100516 19149.939758780598 21159.391687038067 17436.406002120726 21382.28313036572 0.9904351056089533 1.032118687102043 1.1682699922305857 0.9181623436709838 1.0137204919808482 1.0717992681289328 0.8955984560687585 0.9895758819594379 0.8154604396458807 1.0 14.384128287097854 -7.264851086283026 24.942133461138134 0.9242900154803085 1.0325358723951106 0.3231144954983446 0.07604910874671697 355.0361403756443 2595561.921314161 0.03033803728037918 0.02142121823432689 5.434366366387901e-08 7.264851086283026 0.10824585691480204 TLEAEFNS(ph)PSPPTPEPGEGPR ddPTM_A459_Selumetinib_30min_R2 1 TLEAEFNSPSPPTPEPGEGPR 21 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 TLEAEFNS(0.983)PS(0.016)PPT(0.001)PEPGEGPR 84.734 0.0011541 5354500.0 9770.1 10059.0 10127.0 12228.0 12310.0 9544.5 8150.6 7312.0 8187.8 11377.0 True False 9227.116954809117 10830.49295521715 9475.439845443914 10562.525305523433 10763.507747203701 10859.168238655495 8529.619050107507 7333.2767094332385 9825.588786246666 11048.516449004037 0.8351453335294523 0.9802667177269271 0.8576210108550885 0.9560129954348384 0.9742038939693095 0.9828621144546867 0.7720148754339236 0.6637340626934843 0.8893129527025675 1.0 13.431565042799221 -7.266499695160642 24.78968468323688 0.8032433067880743 0.9330200378067922 0.18922512058686647 0.09421516313208611 473.92019091543835 2321647.682495337 0.037237209552022296 0.0259859894432566 5.4137762788555866e-08 7.266499695160642 0.1297767310187179 TLEAEFNSPS(ph)PPTPEPGEGPR ddPTM_A459_Selumetinib_30min_R1 2 TLEAEFNSPSPPTPEPGEGPR 21 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 TLEAEFNS(0.005)PS(0.772)PPT(0.223)PEPGEGPR;TLEAEFNS(0.001)PS(0.958)PPT(0.041)PEPGEGPR 205.33 2.2475e-17 12365200.0 676.81 1204.77 1113.53 1100.71 1156.9299999999998 1157.46 1117.44 1038.53 506.58 921.6199999999999 True False 692.5783561569909 1063.7149683176217 962.3187421824599 908.4916613856856 1052.2858857725812 1145.8170032895937 1033.1506011438948 1010.9848107791346 859.6292608606841 1039.9189043390134 0.6659926589152673 1.0228826150571169 0.9253786407451866 0.8736177961522252 1.0118922556191325 1.1018330357383883 0.9934915086485321 0.9721765866173289 0.8266310548581441 1.0 10.022255312192236 -4.755428706140277 24.999688905446295 0.9706906405515966 0.6659921620836533 0.6005713154971319 0.0743172472598095 145.80587218837252 606378.5641617461 0.019477782815402817 0.17320233548099326 1.7561891668643737e-05 4.755428706140277 -0.3046984784679433 TLEAEFNSPS(ph)PPTPEPGEGPR ddPTM_A459_Selumetinib_30min_R2 1 TLEAEFNSPSPPTPEPGEGPR 21 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 TLEAEFNS(0.005)PS(0.776)PPT(0.219)PEPGEGPR 190.37 1.0835e-17 0.0 13627.0 11574.0 14866.0 16435.0 17540.0 11031.0 10527.0 13295.0 9509.9 13763.0 True False 12869.66589320313 12461.68858372436 13909.537744876987 14196.524648043638 15336.46839041048 12550.420120552015 11016.526358854777 13333.686248894262 11412.14572880715 13365.626429431526 0.9628928326818804 0.932368463948935 1.0406947866093093 1.0621667995135977 1.1474560112378347 0.9390072501888574 0.8242431746106597 0.9976102743327517 0.8538429372586122 1.0 13.706239835944903 -6.978351007976898 24.99077347138663 0.9134249615727509 1.0279215298380442 0.34006630935865967 0.07420870541410154 272.5346872124085 314602.7434859123 0.02693598710025623 0.023753537601778642 1.0511119946577961e-07 6.978351007976898 0.11449656826529331 TLEAEFNSPSPPT(ph)PEPGEGPR ddPTM_A459_Selumetinib_30min_R1 2 TLEAEFNSPSPPTPEPGEGPR 21 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 TLEAEFNS(0.001)PS(0.013)PPT(0.987)PEPGEGPR;TLEAEFNSPSPPT(1)PEPGEGPR 269.39 1.6011999999999997e-59 19112800.0 2467.59 3085.1 3259.08 3027.25 3185.29 2513.1400000000003 2873.95 2668.45 1644.29 2685.9300000000003 True False 2525.0800459056873 2723.8950577759206 2816.514836845002 2498.597616020401 2897.1810819086245 2487.86009334855 2657.165637669581 2597.6740376528182 2790.2400358099703 3030.695278673732 0.8331685681744593 0.898769030639045 0.9293296019115264 0.8244304973853448 0.9559460175014577 0.8208875735066532 0.8767511720387765 0.8571214849384631 0.9206600397751015 1.0 11.565433088270202 -8.588911367936134 3.7444468093350523 0.999935090734976 0.8767637479291347 0.4562890458650021 0.04206598875982016 0.2640265601742709 10.067678116215369 0.038195761732941855 0.010036172997420616 2.5768469936711114e-09 8.588911367936134 -0.1231713428058413 TLEAEFNSPSPPT(ph)PEPGEGPR ddPTM_A459_Selumetinib_30min_R2 2 TLEAEFNSPSPPTPEPGEGPR 21 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 TLEAEFNS(0.008)PS(0.025)PPT(0.968)PEPGEGPR;TLEAEFNS(0.097)PS(0.199)PPT(0.704)PEPGEGPR 174.91 4.7925e-11 17098000.0 27551.0 24513.0 30328.0 31804.0 32878.0 20753.0 20636.3 26314.0 20856.0 27549.0 True False 26019.825715391442 26393.068278281946 28376.729498629695 27472.24033503985 28747.57170695072 23611.537373022948 21595.92884005269 26390.56938348278 25027.78276532897 26753.58878910189 0.9725732842986153 0.9865244056166849 1.0606700178552866 1.0268618745545908 1.074531418329233 0.8825558903200732 0.8072161462259531 0.9864310015198041 0.9354925413043678 1.0 14.707444810538437 -6.767332684355795 24.999998438996442 0.9142958598621432 1.024307741128586 0.4340088794211461 0.057815809713218105 136.17352262775327 577658.2753431846 0.02086241577339331 0.01888960943636729 1.708705886750242e-07 6.767332684355795 0.11001188126644268 TLEEVVMAEEEDEGTDRPGS(ph)PA ddPTM_A459_Selumetinib_30min_R1 2 TLEEVVMAEEEDEGTDRPGSPA 22 1 F8WC89;A6NKF1 F8WC89 SAC3D1 SAC3 domain-containing protein 1 1 TLEEVVMAEEEDEGTDRPGS(1)PA;TLEEVVMAEEEDEGTDRPGS(1)PA 258.83 3.4073e-54 16527800.0 6163.299999999999 6362.5 6527.8 6560.8 6252.0 5502.0 5663.5 5633.9 3264.7 4537.2 True False 6306.892898305844 5617.575542154 5641.360614638728 5415.0794414688735 5686.507703880247 5446.654875416296 5236.29763528999 5484.470670513672 5539.957455746129 5119.593816070578 1.2319127502866134 1.0972697725589557 1.1019156631001286 1.0577166150312074 1.1107341535631414 1.0638841812643538 1.022795523123939 1.0712706647347165 1.0821087872940263 1.0 12.321813637311896 -1.5228787470905785 0.84486744389709 1.0604085369755403 57.60999879163652 0.7380988807412794 0.030342397025436358 328.7647648959065 0.9348711239275198 0.010224652126817696 35719.91079682306 0.029999999874952988 1.5228787470905785 56.549590254660984 TLEGELHDLR ddPTM_A459_Selumetinib_30min_R1 6 TLEGELHDLR 10 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;;;; 185.33 0.00016875 129125200.0 32218.800000000003 37384.1 37376.5 40807.5 37659.299999999996 31372.3 35505.8 32759.0 18828.21 28313.4 False True 32969.435353128436 33007.1521926034 32300.9765944184 33681.23617664632 34253.02296428944 31056.7231457693 32827.568920116435 31890.124903771368 31950.097211950233 31947.700685870775 1.031981477393443 1.0331620581133456 1.011057944733527 1.0542616668354547 1.072159254936247 0.9721113719931801 1.0275408938783126 0.998197811396021 1.0000750140394459 1.0 14.96342448197491 -6.76493195408037 24.999999834938592 1.0012196279591026 1.0392416027216496 0.5267452719842212 0.019352510925915015 83.34161318816592 596555.6657601291 0.0068953656519301805 0.006316071864666796 1.7181775727428687e-07 6.76493195408037 0.038021974762546984 TLEGELHDLR ddPTM_A459_Selumetinib_30min_R2 4 TLEGELHDLR 10 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q5TCI8;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ;;; 185.33 0.00013633 79434900.0 201482.0 183288.0 213219.0 216567.0 225114.0 156829.0 156391.0 163807.0 152767.0 180285.0 False True 190284.43703635066 197345.60023619028 199500.7216752945 187070.20100108755 196833.16677530576 178430.7711980828 163663.49138288735 164283.65125029138 183324.66866661934 175079.70361331583 1.0868446376663756 1.1271757728814262 1.1394851462389688 1.0684859360640349 1.124248914711639 1.0191402402197813 0.9347941994713304 0.9383363568693902 1.0470926377138123 1.0 17.41765232123739 -6.900337203384437 3.967566348137637 0.9748767712063134 1.109541517174165 0.7494321708031992 0.03552162179002271 0.10771971575779722 3.176355669428452 0.013051371532922705 0.011392076972604063 1.2579483117727366e-07 6.900337203384437 0.1346647459678515 TLEHSLPPS(ph)PRPLPR ddPTM_A459_Selumetinib_30min_R2 2 TLEHSLPPSPRPLPR 15 1 Q8TE67-2;Q8TE67;Q8TE67-3 Q8TE67-2 EPS8L3 Epidermal growth factor receptor kinase substrate 8-like protein 3 1 TLEHSLPPS(1)PRPLPR;TLEHSLPPS(1)PRPLPR 75.462 0.01654 5980700.0 38844.0 38215.0 39159.0 46714.0 43985.0 32248.0 38138.0 39644.0 26593.0 36186.0 True False 36685.20598485227 41145.96761940785 36639.55257309548 40351.4726138552 38459.21106911088 36689.869281802334 39911.49256901333 39759.3574765825 31912.343070502175 35141.2161574809 1.0439367214968365 1.1708748904709905 1.0426375800114593 1.1482662533085137 1.0944188982180016 1.044069423134969 1.1357459113012778 1.1314166618026533 0.9081172070850098 1.0 15.100876500150317 -8.257471254654343 24.999887286434564 0.9540585968807369 1.1023370680145028 0.5972813397618031 0.04839666525195269 196.68393096827424 1239165.359690219 0.03315168789749153 0.011471047577904563 5.527499924842682e-09 8.257471254654343 0.1482784711337659 TLENSPISSCDTS(ph)DTEGPVPVNSAAVLKK ddPTM_A459_Selumetinib_30min_R1 2 TLENSPISSCDTSDTEGPVPVNSAAVLKK 29 1 Q8N556;Q8N556-2 Q8N556 AFAP1 Actin filament-associated protein 1 1 TLENSPISSCDT(0.257)S(0.739)DT(0.004)EGPVPVNSAAVLKK;TLENS(0.002)PIS(0.007)S(0.032)CDT(0.144)S(0.671)DT(0.144)EGPVPVNSAAVLKK 137.4 3.2782e-14 16852000.0 3714.2599999999998 3983.69 7341.259999999999 7403.5 4590.12 4364.28 3996.79 3534.0899999999997 2697.1400000000003 2949.76 True False 3800.7950313081437 3517.2777228327623 6344.357214654669 6110.617705907027 4174.944456451503 4320.3793056491895 3695.308912465912 3440.35445285782 4576.849588688433 3328.3904290955575 1.1419318473226578 1.0567503415723174 1.906133715322171 1.835907726596696 1.254343366678285 1.298038615867307 1.1102390152798447 1.0336390895681933 1.375093963941041 1.0 11.700608960052794 -6.501932075970574 22.72220478534593 1.1748493735357948 1.4922066983106903 0.24557431217912562 0.26678480347929695 386.8286599031404 419618.2589783316 0.09122192794328227 0.10210451321809028 3.1482406631380923e-07 6.501932075970574 0.31735732477489553 TLEPVKPPTVPNDY(ph)MTSPAR ddPTM_A459_Selumetinib_30min_R1 1 TLEPVKPPTVPNDYMTSPAR 20 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TLEPVKPPT(0.002)VPNDY(0.726)MT(0.209)S(0.063)PAR 107.69 0.0040198000000000005 8250300.0 978.98 1394.2 1718.7 1728.3 1257.7 1284.9 852.73 1245.6 823.62 1302.9 True False 1001.7883292365221 1230.9664158540043 1485.3099801433239 1426.4848492090389 1143.9412570649692 1271.9750725958565 788.4078895631387 1212.5626417209805 1397.6229851752469 1470.139906320717 0.6814238052646793 0.837312428947469 1.0103187960257283 0.9703055083914206 0.7781172745170103 0.865206819519101 0.5362808574704075 0.8247940461364872 0.9506734557481972 1.0 10.521737740778555 -4.771112866831018 5.4731472372671 0.8539077414881114 0.674114138991281 0.14226705059294342 0.13280821756378555 0.3244761718370932 30.138566026563307 0.03512097837800224 0.21736592456899562 1.6938975238636032e-05 4.771112866831018 -0.1797936024968304 TLEPVKPPTVPNDYMT(ph)SPAR ddPTM_A459_Selumetinib_30min_R1 2 TLEPVKPPTVPNDYMTSPAR 20 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TLEPVKPPTVPNDY(0.001)MT(0.5)S(0.5)PAR;TLEPVKPPTVPNDY(0.004)MT(0.498)S(0.498)PAR 88.41799999999998 0.0027455 167343000.0 3639.3 4520.4 4520.0 4829.0 4155.0 3536.2 4276.9 4045.3999999999996 2344.2 3518.7 True False 3724.0886091549137 3991.1494665230534 3906.2088265827774 3985.7058015566986 3779.1809836248303 3500.6290386127075 3954.2899896480567 3938.1028506888715 3977.936186406128 3970.359420040456 0.9379726657383999 1.0052363134626199 0.9838426231303198 1.0038652373482313 0.9518485819065525 0.8816907156926961 0.9959526509586794 0.9918756550883608 1.0019083326127676 1.0 11.95505389909302 -7.461819946442543 24.999998591759528 0.9969196287490746 0.9631585350346044 0.2202488904191099 0.033636992711926716 437.7570668269257 179236.03926635146 0.015251297382808223 0.010282396950219694 3.4528686167483186e-08 7.461819946442543 -0.033761093714470225 TLEPVKPPTVPNDYMT(ph)SPAR ddPTM_A459_Selumetinib_30min_R2 4 TLEPVKPPTVPNDYMTSPAR 20 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TLEPVKPPTVPNDY(0.277)MT(0.361)S(0.361)PAR;TLEPVKPPTVPNDY(0.013)MT(0.493)S(0.493)PAR;TLEPVKPPTVPNDY(0.299)MT(0.351)S(0.351)PAR;TLEPVKPPTVPNDY(0.063)MT(0.468)S(0.468)PAR 91.065 0.0022135 21646300.0 103093.0 100175.0 118010.0 117022.0 112889.0 91305.0 96237.3 92088.7 76171.1 103353.2 True False 97363.5037739774 107858.1003866067 110417.36507957327 101083.40172579029 98706.87457953536 103881.4349657331 100712.52514059214 92356.66287089499 91407.44839835796 100369.124572137 0.970054328848914 1.0746143382877396 1.1001128638938602 1.0071165027761093 0.9834386321521918 1.0349939327314919 1.0034213765430258 0.9201700549307539 0.910712819186361 1.0 16.61495601188068 -7.621545543542626 4.150649283202951 0.93702793118214 1.0300750367165121 0.4365245748231307 0.04272161806385684 0.19922974320099432 6.277298534566954 0.02240761992727055 0.012323773692461138 2.3903112553212565e-08 7.621545543542626 0.09304710553437212 TLEPVKPPTVPNDYMTS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 TLEPVKPPTVPNDYMTSPAR 20 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TLEPVKPPTVPNDY(0.003)MT(0.064)S(0.933)PAR;TLEPVKPPT(0.001)VPNDY(0.044)MT(0.342)S(0.612)PAR 122.87 0.00013227 59314000.0 131072.0 121789.0 126246.0 143451.0 145296.0 106505.0 126459.0 109148.0 90422.0 124947.0 True False 123787.54296278859 131129.82468664323 118123.46980625187 123912.72633322238 127042.61751727927 121175.09699387108 132339.59407375482 109465.6026095758 108508.92660177301 121339.45545870707 1.0201755273651663 1.0806857851053067 0.9734959610598415 1.021207206384662 1.0470017113313406 0.9986454656136814 1.0906559088588559 0.9021435129715737 0.8942592184180321 1.0 16.888689216478333 -7.774145592711555 24.998643239491 0.9236509898402758 1.0314091879725813 0.5406681436857939 0.04242027693441653 162.29705334566623 319303.9734641175 0.021887088963875628 0.010624879266343501 1.682110056622658e-08 7.774145592711555 0.10775819813230547 TLEPVRPPVVPNDYVPS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 2 TLEPVRPPVVPNDYVPSPTR 20 1 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 TLEPVRPPVVPNDYVPS(0.618)PT(0.382)R;T(0.001)LEPVRPPVVPNDY(0.001)VPS(0.755)PT(0.244)R 97.825 0.00050258 20573700.0 1094.58 1406.97 1744.77 1417.15 1445.81 1055.17 1090.65 1057.5 745.35 960.84 True False 1120.0815843180787 1242.2412983173924 1507.8398173355824 1169.671355700161 1315.0367407784884 1044.5559478177056 1008.3813924126478 1029.45166475589 1264.8045117898678 1084.173173374164 1.03312054921278 1.1457960119519364 1.3907739597013669 1.0788602636790114 1.212939752683449 0.9634585815906497 0.930092550873919 0.9495269667594065 1.166607459815246 1.0 10.082379499300423 -6.762260161646493 24.999983435458322 0.9942922446395739 1.1777723376818408 0.38512086709467386 0.10730239765797335 22.894802743963037 697330.4740302308 0.03731088388602595 0.034842138377620485 1.728780432848817e-07 6.762260161646493 0.18348009304226687 TLEPVRPPVVPNDYVPS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 TLEPVRPPVVPNDYVPSPTR 20 1 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 TLEPVRPPVVPNDYVPS(0.693)PT(0.307)R 83.73299999999998 0.0015364 14064000.0 24698.0 18147.0 23407.0 26695.0 27830.0 21660.0 19931.0 25196.0 19461.0 24134.0 True False 23325.38403392754 19538.816548198214 21901.019103614668 23059.094948556423 24333.746596643316 24643.468390096714 20857.83099252726 25269.31618857766 23353.743785772298 23437.18871233746 0.9952296036959815 0.8336672451637887 0.9344558928300924 0.9838677851502724 1.0382536444669195 1.051468616503662 0.8899459422600282 1.0781718105668432 0.9964396358458625 1.0 14.516511908609623 -5.76953798830135 3.228742903793418 1.0089392955292351 0.908864822847874 0.30358492430438033 0.05939328949050427 0.26637650542925045 5.749944513699583 0.016583633527818938 0.028472082545048075 1.700051241452399e-06 5.76953798830135 -0.10007447268136116 TLEPVRPPVVPNDYVPSPT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 TLEPVRPPVVPNDYVPSPTR 20 1 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 TLEPVRPPVVPNDYVPS(0.079)PT(0.921)R 107.09 0.00063185 17713000.0 1067.5 1113.2 1050.2 1406.1 1360.0 1076.9 1017.3 1004.9 485.83 1041.4 True False 1092.3706730065858 982.8660264873603 907.5886083356719 1160.551030765971 1236.9882401275024 1066.0673637469665 940.564241967071 978.2467876247703 824.4180263807218 1175.0738340950156 0.9296187535720905 0.8364291655292585 0.7723673032296325 0.9876409439920605 1.0526898006202055 0.9072343650371548 0.8004299088928719 0.832498145427745 0.7015882768044513 1.0 10.198535693993756 -10.252911395170155 5.090206395541209 1.0000000421123698 0.8720817536689175 0.13616757144678282 0.09874328272127934 48989773.68093064 20.572746221091396 25.204922938472873 0.025902660542121935 5.585841455392567e-11 10.252911395170155 -0.12791828844345232 TLEPVRPPVVPNDYVPSPT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 TLEPVRPPVVPNDYVPSPTR 20 1 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 TLEPVRPPVVPNDYVPS(0.381)PT(0.619)R 106.5 0.00065158 16581000.0 19733.0 17261.0 19193.0 22803.0 22165.0 17195.0 16038.0 14394.0 17157.0 19785.0 True False 18636.318857457798 18584.863197137212 17958.143275758368 19697.192062630904 19380.43454238588 19563.45516933115 16783.798778694105 14435.884156945021 20588.87940663353 19213.75564239649 0.9699466988294294 0.9672686351921963 0.9346503416610793 1.0251609539140634 1.0086749776093542 1.0182004774830709 0.8735303545580378 0.7513306833720337 1.0715697539736966 1.0 14.229851924429196 -7.2621245172642315 24.999747170849286 0.9033852537988121 0.9867027806330464 0.10378161745237713 0.0824343179645083 108.37764729135017 3954429.3758856966 0.03231472813951954 0.023279124525307858 5.468591495551478e-08 7.2621245172642315 0.08331752683423432 TLEVVS(ph)PSQSVTGSAGHTPY(ph)YQSPTDEK ddPTM_A459_Selumetinib_30min_R2 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 TLEVVS(0.859)PS(0.043)QS(0.054)VT(0.017)GS(0.026)AGHT(0.006)PY(0.338)Y(0.338)QS(0.263)PT(0.055)DEK 113.65 2.0646e-09 24668000.0 64998.0 46498.0 88155.0 117830.0 128850.0 78596.0 74611.0 95990.0 86927.0 104100.0 True False 61385.671367609655 50064.24708536505 82483.20327590688 101781.3507319123 112662.71106638481 89421.88557654854 78080.55933889182 96269.31500800003 104314.82894331384 101094.36251571744 0.6072116173447936 0.4952229366655477 0.815903095121481 1.006795514597444 1.1144311934196016 0.8845387947586677 0.7723532489435542 0.9522718439718413 1.0318560436749944 1.0 16.62534302264327 -5.437997554931764 3.55250049526459 0.9574430038382143 0.5533719895170547 0.7655884831763743 0.09063976852799888 0.11951095384902277 2.8213573968302454 0.027022416088364625 0.060416837485570245 3.647560004879655e-06 5.437997554931764 -0.40407101432115966 TLEVVS(ph)PSQSVTGSAGHTPYYQS(ph)PTDEK ddPTM_A459_Selumetinib_30min_R2 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 T(0.003)LEVVS(0.525)PS(0.087)QS(0.117)VT(0.036)GS(0.232)AGHT(0.044)PY(0.125)Y(0.125)QS(0.648)PT(0.059)DEK 92.648 3.0184e-05 22813000.0 55675.0 48827.0 67282.0 78848.0 95082.0 60376.0 60671.0 65579.0 56640.0 71865.0 True False 52580.80638468365 52571.873896449746 62953.14937110271 68108.76637961325 83136.94911613512 68692.24596124097 63492.32171730581 65769.82403281218 67969.58265382783 69790.07072230593 0.7534138573079 0.7532858664899877 0.9020359016627556 0.9759091182271105 1.1912432278072378 0.9842696138619319 0.9097615328395524 0.942395148079298 0.9739147983425637 1.0 16.09073417331004 -5.442104034819535 2.447708767803565 0.9979910618918149 0.7477197900908585 0.6538204829337808 0.07039367234515961 0.19872637025167836 2.2987000971237608 0.022089876588148507 0.056712490383653266 3.6132329762822794e-06 5.442104034819535 -0.2502712718009563 TLEVVS(ph)PSQSVTGSAGHTPYYQSPTDEK ddPTM_A459_Selumetinib_30min_R1 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.001)LEVVS(0.425)PS(0.425)QS(0.14)VT(0.002)GS(0.007)AGHTPYYQSPTDEK 149.88 2.2338e-14 113370000.0 3843.9 4378.1 3230.3 3761.8 5425.3 3240.9 5043.5 3822.7 690.26 2202.8 True False 3933.455391072617 3865.5100166765274 2791.643002767777 3104.8722477316205 4934.5825729145145 3208.2994885017583 4663.064734454856 3721.3095781204183 1171.3208054042718 2485.5508370890134 1.582528642093411 1.5551924985785734 1.123148624084168 1.2491686757724634 1.9853074414256269 1.2907800720178397 1.876068944104184 1.4971770130755726 0.47125200093516495 1.0 11.279349895754384 -8.247504997016149 23.852068413715752 0.7356260824923829 1.5185928050335844 0.5603611653516047 0.2778757101763951 267.5947416266831 458056.5649057722 0.18876530296938157 0.07042962355359578 5.655812494428122e-09 8.247504997016149 0.7829667225412015 TLEVVSPS(ph)QSVTGSAGHTPYYQSPTDEK ddPTM_A459_Selumetinib_30min_R2 2 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TLEVVS(0.021)PS(0.421)QS(0.128)VT(0.021)GS(0.092)AGHT(0.274)PY(0.03)Y(0.012)QS(0.002)PT(0.001)DEK;TLEVVS(0.05)PS(0.334)QS(0.334)VT(0.044)GS(0.205)AGHT(0.033)PYYQSPTDEK 110.36 3.8565e-10 476010000.0 105167.0 103739.0 134674.0 189203.0 200737.0 147619.0 114644.0 129929.0 123199.0 179552.0 True False 99322.23915685718 111695.44772654078 126009.22146196415 163433.22500662037 175518.62344845093 167952.17729813867 119975.17316277645 130307.07187909624 147842.24246767195 174367.8672278782 0.56961320188114 0.6405735729999383 0.722663088476531 0.9372898092114212 1.0065995887824266 0.963206007897344 0.6880578117410996 0.7473112675559672 0.8478754991850627 1.0 17.41177467703921 -5.493459165960482 2.91786870108791 0.8733723599177569 0.6053520317561946 0.5586879782683762 0.10046857812411387 0.22605476123555873 3.8305180293429464 0.0314545969579979 0.070506445798552 3.2102646314633403e-06 5.493459165960482 -0.2680203281615623 TLEVVSPSQS(ph)VTGSAGHTPYYQS(ph)PTDEK ddPTM_A459_Selumetinib_30min_R1 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 TLEVVS(0.155)PS(0.218)QS(0.37)VT(0.014)GS(0.172)AGHT(0.072)PY(0.008)Y(0.028)QS(0.912)PT(0.052)DEK 122.76 1.5489e-11 69058000.0 4099.0 4789.5 3639.4 3650.5 4801.0 4153.8 5041.3 4642.1 1144.9 2863.1 True False 4194.498724734424 4228.743113421857 3145.189469793223 3013.0087033718646 4366.750397685394 4112.016543348638 4661.030682226083 4518.9764283341065 1942.811679812462 3230.6067739556747 1.2983625115100357 1.3089624981637822 0.9735599810998157 0.932644829343506 1.3516811866083545 1.2728310286781614 1.4427725218067762 1.3988011369148787 0.6013767121009318 1.0 11.657589442635034 -8.25817355907452 24.988210528892008 0.8006883468786202 1.2407099731725693 0.4893523769790237 0.18244842836811326 240.52418388187758 1840392.8548621947 0.14492891530908383 0.04968780636782804 5.51856854148167e-09 8.25817355907452 0.44002162629394903 TLEVVSPSQS(ph)VTGSAGHTPYYQS(ph)PTDEK ddPTM_A459_Selumetinib_30min_R2 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 TLEVVS(0.196)PS(0.249)QS(0.387)VT(0.049)GS(0.12)AGHT(0.001)PY(0.022)Y(0.058)QS(0.678)PT(0.242)DEK 99.641 2.9674e-06 24389000.0 81699.0 63068.0 95057.0 132360.0 138040.0 93023.0 87561.0 96950.0 96866.0 112340.0 True False 77158.49664700974 67905.11280441747 88941.13611023611 114332.33966626436 120698.18110674253 105836.07387128186 91632.75999882998 97232.10844906354 116241.90666217676 109096.45230562669 0.707250281896016 0.622431906531531 0.8152523224226691 1.0479931954704602 1.1063437770516529 0.9701147162401661 0.8399242877497675 0.891249040589093 1.0654966701990687 1.0 16.735244662035107 -5.532263080730519 3.926499833396415 0.9812976996534587 0.6704341027647369 0.7394700961375644 0.07764663283451284 0.11662146754351058 4.049293922469325 0.02383866737112469 0.04727834371924689 2.935870663242613e-06 5.532263080730519 -0.3108635968887218 TLEVVSPSQS(ph)VTGSAGHTPYYQSPTDEK ddPTM_A459_Selumetinib_30min_R1 2 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TLEVVS(0.058)PS(0.344)QS(0.595)VT(0.001)GS(0.001)AGHTPYYQSPTDEK;TLEVVS(0.011)PS(0.25)QS(0.629)VT(0.005)GS(0.095)AGHT(0.008)PY(0.001)YQSPTDEK 148.94 2.6318000000000002e-14 336550000.0 8704.5 9400.0 7067.6 8573.8 13313.7 8224.5 11828.1 8476.8 1651.0700000000002 4940.9 True False 8907.297913991406 8299.443630058562 6107.858739547889 7076.546780158799 12109.47818572465 8141.768997248513 10935.896894142064 8251.967727473035 2801.7452006183635 5575.112643441582 1.5976893174471947 1.4886593618555515 1.0955579071093775 1.2693100987804193 2.1720598237544 1.460377487946594 1.9615562220086746 1.4801436769498166 0.502545038962444 1.0 12.444785239200467 -8.192574591827654 6.46983988092661 0.7556936592863288 1.5708493769845473 0.5206182737425367 0.3129916504086828 0.1748098509554165 13.254805184330912 0.22569181573719202 0.08284733224422859 6.418379737816905e-09 8.192574591827654 0.8151557176982185 TLEVVSPSQSVT(ph)GS(ph)AGHTPYYQSPTDEK ddPTM_A459_Selumetinib_30min_R1 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 TLEVVS(0.019)PS(0.182)QS(0.203)VT(0.399)GS(0.557)AGHT(0.307)PY(0.129)Y(0.177)QS(0.019)PT(0.007)DEK 101.04 1.7194999999999996e-06 61643000.0 2629.6 2963.1 2131.2 2442.1 3266.2 2272.9 3405.8 2659.1 972.74 1914.1 True False 2690.8645636891033 2616.1788744921832 1841.7947458436322 2015.6330788945165 2970.7727866944447 2250.0366896280825 3148.897763974688 2588.5720300258986 1650.6687338813651 2159.7933799128764 1.2458898099769384 1.2113097941793474 0.8527643259643328 0.9332527350258962 1.3754893474181693 1.0417833069378362 1.4579625038491928 1.198527624957494 0.7642715961783119 1.0 11.076677585924347 -8.251022299312138 24.67006126493857 0.8821357944648472 1.1607833537752268 0.27623202705497285 0.18281839423681842 722.9965833432467 1712235.4739863393 0.13195141082808146 0.04865234528320997 5.6101916916691234e-09 8.251022299312138 0.27864755931037954 TLEVVSPSQSVTGS(ph)AGHTPYYQS(ph)PTDEK ddPTM_A459_Selumetinib_30min_R1 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 TLEVVS(0.179)PS(0.047)QS(0.098)VT(0.183)GS(0.493)AGHT(0.001)PY(0.006)Y(0.025)QS(0.814)PT(0.153)DEK 134.42 1.0056000000000002e-11 6122600.0 1988.6 1667.5 1554.5 1578.3 1997.9 1712.9 2245.1 1855.3 776.35 1477.1 True False 2034.9305108579842 1472.2683248002807 1343.4074382572846 1302.6795333603102 1817.1902977578939 1695.6697811887627 2075.7502994596193 1806.0914171362688 1317.409247639449 1666.70017317241 1.220933760980346 0.8833432362330376 0.8060282586400844 0.781592006965944 1.0902922595244229 1.0173814153755152 1.2454251417689723 1.0836330650272512 0.7904296578621469 1.0 10.702778882338556 -6.288752981000201 24.87403696251817 1.0513962184413634 0.9117901973755019 0.11277819717311577 0.15382379883862152 1361.1874236301182 1239606.531787846 0.04935800881411024 0.05598135385604811 5.143361136614543e-07 6.288752981000201 -0.1396060210658615 TLEVVSPSQSVTGSAGHT(ph)PYYQSPTDEK ddPTM_A459_Selumetinib_30min_R1 2 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TLEVVS(0.002)PS(0.008)QS(0.008)VT(0.008)GS(0.036)AGHT(0.536)PY(0.153)Y(0.153)QS(0.079)PT(0.017)DEK;TLEVVS(0.011)PS(0.045)QS(0.08)VT(0.058)GS(0.179)AGHT(0.625)PY(0.001)YQSPTDEK 123.97 5.1771e-12 289704800.0 2358.71 2720.79 2019.84 2427.45 3664.23 2141.4 3273.45 2315.02 483.48 1780.16 True False 2413.663353749289 2402.238641939045 1745.5568221869369 2003.5414263799564 3332.801043472351 2119.8594602356334 3026.531031030287 2253.618149355256 820.4302480179311 2008.6608762267942 1.201628100749032 1.1959403751874602 0.869015194573765 0.9974513120121827 1.659215392163615 1.0553595608521644 1.50674066829814 1.1219505373095164 0.40844637227120356 1.0 10.972018297969758 -8.104938676495378 6.991357628755185 0.7113549075050905 1.2089526027385484 0.38127113783073563 0.25515937469718586 0.26184469438759306 15.10946126763117 0.1729516583933531 0.06459026683466224 7.85346519741999e-09 8.104938676495378 0.497597695233458 TLEVVSPSQSVTGSAGHT(ph)PYYQSPTDEK ddPTM_A459_Selumetinib_30min_R2 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TLEVVS(0.001)PS(0.006)QS(0.006)VT(0.006)GS(0.026)AGHT(0.889)PY(0.029)Y(0.029)QS(0.008)PT(0.002)DEK 69.98100000000001 0.00069932 23157000.0 3310.3 6903.0 6091.7 7422.3 5852.6 3182.6 2830.2 4509.0 3401.2 5112.8 True False 3126.32677818084 7432.437903356597 5699.76665414147 6411.36993581833 5117.34406509215 3620.974261233692 2961.809907934906 4522.120443494864 4081.535037468207 4965.180179350254 0.6296502171629053 1.4969120223003087 1.147947596714878 1.2912663194948397 1.030646196159151 0.7292734866486829 0.596516098298469 0.9107666348749969 0.822031606112292 1.0 12.277630356723597 -6.592166341988678 4.400096909392262 0.7945960121816343 1.1674212881688126 0.31887107483339394 0.22685689897506922 0.22480082603106918 8.529963874066997 0.07368927412870949 0.07431096781690189 2.557606093731226e-07 6.592166341988678 0.3728252759871783 TLEVVSPSQSVTGSAGHTPYYQS(ph)PTDEK ddPTM_A459_Selumetinib_30min_R1 1 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TLEVVSPSQSVTGS(0.002)AGHT(0.014)PY(0.063)Y(0.282)QS(0.594)PT(0.045)DEK 118.09 2.7208e-12 15489000.0 999.44 1161.7 998.64 1032.6 1297.4 1075.8 1198.4 1202.5 347.24 640.63 True False 1022.7250074282922 1025.6876239403214 863.0301731368638 852.27579430264 1180.0503990745747 1064.9784287482462 1108.0037231626245 1170.6057937295109 589.2409185938333 722.8611007646333 1.414829220090093 1.4189276789902818 1.19390872219291 1.1790312044749862 1.6324718508525806 1.4732822496904667 1.53280308207288 1.6194062628231882 0.8151509577296963 1.0 9.497574646785953 -8.268195480266677 24.912189515592623 0.9075754056854771 1.4274801887108364 0.6618231152316031 0.15021595438947155 359.4843599116092 1325529.2138204114 0.14501970560909813 0.040787778642381534 5.39267838060817e-09 8.268195480266677 0.5199047830253593 TLEVVSPSQSVTGSAGHTPYYQS(ph)PTDEK ddPTM_A459_Selumetinib_30min_R2 2 TLEVVSPSQSVTGSAGHTPYYQSPTDEK 28 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TLEVVSPSQSVT(0.001)GS(0.001)AGHT(0.107)PY(0.096)Y(0.119)QS(0.543)PT(0.133)DEK;TLEVVSPSQSVTGSAGHT(0.011)PY(0.195)Y(0.297)QS(0.447)PT(0.051)DEK 110.27 3.9345e-10 207868000.0 109095.0 84517.0 166092.0 209142.0 235701.0 140521.0 141757.0 150462.0 163642.0 221213.0 True False 103031.93664188699 90999.18213501209 155405.82154729601 180656.49880992627 206090.13318632482 159876.49222736753 148348.98138616676 150899.819509675 196374.97253950706 214826.0059096007 0.4796064433895544 0.4235948145556677 0.7234032066522298 0.8409433394481437 0.959335124784883 0.7442138653112786 0.6905541103277429 0.7024280830002211 0.914111732925585 1.0 17.712809124770395 -5.374910708906684 3.4434298518258557 0.8173613004205159 0.44879508706120946 0.6916335328957419 0.10051952708337256 0.14085813853557924 3.051871717239949 0.02814635648434926 0.06660208751000897 4.2178321328671785e-06 5.374910708906684 -0.36856621335930645 TLFLGIPDENFEDHSAPPS(ph)PEEK ddPTM_A459_Selumetinib_30min_R1 2 TLFLGIPDENFEDHSAPPSPEEK 23 0 Q99683-2;Q99683 Q99683-2 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 1 TLFLGIPDENFEDHS(0.047)APPS(0.953)PEEK;TLFLGIPDENFEDHS(0.002)APPS(0.998)PEEK 96.131 4.8747e-05 6842000.0 1925.3999999999999 2514.81 2232.96 2113.3599999999997 1683.2400000000002 1890.0 1890.59 2029.79 950.69 1939.55 True False 1970.2580738237755 2220.3748760965477 1929.7362967713025 1744.3013486804446 1530.99123920016 1870.9883159826984 1747.9812741772578 1975.9533755128687 1613.2514943496456 2188.510135316869 0.9002736802671955 1.0145600151744627 0.8817579894332547 0.7970268542658093 0.699558669842985 0.8549141654817161 0.7987083294563642 0.902876045043664 0.7371460009784542 1.0 11.095733349990441 -5.514887476506576 4.728733957519806 0.8185486779807734 0.9570532337501401 0.2745999945259463 0.0834443420331902 0.2079761741417765 12.501130721445248 0.021469287159068453 0.042291043623144814 3.05571273030013e-06 5.514887476506576 0.1385045557693667 TLGT(ph)PTQPGSTPR ddPTM_A459_Selumetinib_30min_R1 2 TLGTPTQPGSTPR 13 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 T(0.461)LGT(0.539)PTQPGSTPR;T(0.052)LGT(0.945)PT(0.003)QPGSTPR 170.26 0.00054346 58903000.0 7189.0 8001.3 8024.0 7477.7 6711.6 6210.1 7660.0 6037.200000000001 3795.5 5507.1 True False 7356.4897126410715 7064.504076296543 6934.384872677044 6171.860068813533 6104.536965029221 6147.632032319655 7082.200032898616 5877.073844410653 6440.686287648006 6213.989928696617 1.1838592912209778 1.136870860326341 1.1159311412227424 0.9932201596129846 0.9823860410262438 0.9893212095387349 1.1397186210734824 0.9457810379237881 1.0364816102942958 1.0 12.601304187880576 -5.620277646947805 3.548660565421029 1.0132622936403761 1.1551802513309006 0.6080322650866423 0.04962494633300162 0.15843574974005706 3.8637625625012775 0.013965538601937444 0.026166691045224916 2.3972998215167443e-06 5.620277646947805 0.1419179576905245 TLGT(ph)PTQPGSTPR ddPTM_A459_Selumetinib_30min_R2 2 TLGTPTQPGSTPR 13 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 T(0.334)LGT(0.646)PT(0.019)QPGSTPR;T(0.087)LGT(0.899)PT(0.008)QPGS(0.005)T(0.001)PR 131.08 0.0036479 36740000.0 75334.0 71349.0 82401.0 77634.0 76274.0 58757.0 65494.0 62227.0 57276.0 78263.0 True False 71147.23786589601 76821.23887680584 77099.40937142514 67060.11527388015 66691.77822178837 66850.24340705962 68539.60077389893 62408.07026776558 68732.80042515253 76003.34383830568 0.9361066799542286 1.0107613033479186 1.0144212804038109 0.8823311171222687 0.8774847901912405 0.879569766683964 0.9017971751310628 0.8211226916612571 0.9043391639633519 1.0 16.213775272221703 -5.768508804320166 24.99182855604358 0.8866628422967252 0.9894629135485901 0.441341793649601 0.04664661786257359 121.87014481964133 430836.49909861723 0.012377695583692326 0.018809394684836014 1.7040847725721817e-06 5.768508804320166 0.10280007125186486 TLGTPTQPGST(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TLGTPTQPGSTPR 13 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 TLGTPT(0.001)QPGS(0.08)T(0.918)PR 145.61 0.0014557 9770300.0 2487.4 3362.3 3431.8 3025.5 3222.6 2964.4 3338.4 2801.2 1758.8 2781.1 True False 2545.3515803621385 2968.640352909136 2965.7804095280476 2497.1532206688353 2931.1163989962415 2934.5808274598453 3086.5818002387414 2726.903076420047 2984.555142330474 3138.0812752080333 0.8111171627297636 0.9460049286685015 0.9450935617757181 0.7957579812853289 0.9340473180707942 0.9351513138439357 0.9835888651526791 0.8689714629010914 0.9510764319297685 1.0 11.615667002749209 -6.487937905795732 24.96532276759363 0.9410068781699056 0.8821765376056622 0.2743493846612428 0.05582868054024492 980.2457881585002 700388.721399808 0.017183830659147428 0.019475918027411974 3.2513378077638246e-07 6.487937905795732 -0.05883034056424341 TLGTPTQPGST(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TLGTPTQPGSTPR 13 0 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 TLGTPTQPGS(0.011)T(0.989)PR 144.88 0.0015108 8844900.0 38332.0 32620.0 40787.0 41658.0 42913.0 37599.0 32116.0 32680.0 34725.0 34624.0 True False 36201.66089515391 35121.849110168376 38162.8088255279 35984.10853594169 37521.885292912484 42777.92096026067 33609.457636646715 32775.09338953478 41670.970297566564 33624.315156044286 1.076651248572607 1.0445372328677718 1.1349765385085553 1.0701811581573049 1.1159152273817412 1.2722317394937614 0.9995581316874821 0.9747438196861876 1.2393106031804433 1.0 15.037217263395949 -10.673439392066646 4.178189706932196 0.9999774000503957 1.0998959100786037 0.104929861980255 0.08991214781427771 64084265.64994161 0.9699290033024968 17392.455676291796 0.021699147707658177 2.1210973820199e-11 10.673439392066646 0.09991851002820795 TLHCEGT(ph)EINSDDEQESKEVEETATAK ddPTM_A459_Selumetinib_30min_R1 1 TLHCEGTEINSDDEQESKEVEETATAK 27 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 T(0.02)LHCEGT(0.821)EINS(0.158)DDEQES(0.001)KEVEETATAK 59.226000000000006 0.008203499999999999 24027000.0 956.04 776.88 1167.6 999.43 1071.4 706.7 954.48 1022.3 502.42 459.74 True False 978.313871869992 685.9225284382866 1009.0463331677104 824.8983121246252 974.4920591710329 699.591239632261 882.4828051437437 995.1852831016048 852.5700446950626 518.7521072468236 1.885898598199829 1.3222549245702107 1.9451416564320645 1.5901589614789489 1.878531278345954 1.3486041403189784 1.7011647621584622 1.9184216684600244 1.6435018437224538 1.0 9.018901481571515 -8.575349871255241 21.536396618110054 0.9999999993475185 1.6911970913951573 0.4893465894176705 0.2128186870662577 6783.509460650899 2784237.005950574 0.19407837498250038 0.05011082092748788 2.658582420688587e-09 8.575349871255241 0.6911970920476388 TLHCEGT(ph)EINSDDEQESKEVEETATAK ddPTM_A459_Selumetinib_30min_R2 1 TLHCEGTEINSDDEQESKEVEETATAK 27 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 T(0.002)LHCEGT(0.504)EINS(0.484)DDEQES(0.01)KEVEETATAK 56.468 0.011773 46457000.0 42301.0 41365.0 44145.0 39616.0 40125.0 29377.0 24655.0 30816.0 15230.0 42184.0 True False 39950.07976431975 44537.56249056144 41304.75876144182 34220.232458588165 35084.1387779487 33423.41509214547 25801.506352955665 30905.669458136555 18276.42556175489 40966.03831280533 0.975199980512443 1.087182562064824 1.0082683232889185 0.8353317496139593 0.8564201036491722 0.815881068043083 0.6298267397970608 0.754421729095438 0.4461360266814468 1.0 15.322140760948965 -6.241748730878749 0.9127402050294054 0.6921935323642293 1.047684159630636 0.4507713975988342 0.13680934747974494 0.49390932109666824 0.8754701678115895 0.06397632167721569 0.10593086906049501 5.731275286329469e-07 6.241748730878749 0.3554906272664068 TLHCEGTEINS(ph)DDEQESK ddPTM_A459_Selumetinib_30min_R1 4 TLHCEGTEINSDDEQESK 18 0 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 TLHCEGTEINS(1)DDEQESK;TLHCEGTEINS(1)DDEQESK;TLHCEGTEINS(0.995)DDEQES(0.005)K;TLHCEGTEINS(1)DDEQESK 226.72 8.0789e-19 365248000.0 19670.5 27369.3 19360.7 18918.8 17819.9 20530.2 22084.199999999997 22030.0 11661.3 21832.3 True False 20128.78437786983 24164.88963235763 16731.62328071267 15614.986729859382 16208.093191358876 20323.684827930156 20418.371013908563 21445.692836474973 19788.37439234611 24634.688369610718 0.81709109024901 0.9809293817642674 0.6791895651236551 0.6338617519969112 0.6579378211803618 0.8250027166165169 0.8288463287035776 0.870548574218228 0.8032727711204577 1.0 14.588403601130098 -8.757234244457976 0.6636153075922938 0.9979786267110173 0.7660138795064133 0.3131821561237085 0.09837889299540828 1.487923495000247 1.3621078596272262 0.11592901795337333 0.04395759146238472 1.7489031321558963e-09 8.757234244457976 -0.23196474720460403 TLHCEGTEINS(ph)DDEQESK ddPTM_A459_Selumetinib_30min_R2 5 TLHCEGTEINSDDEQESK 18 0 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 TLHCEGTEINS(1)DDEQESK;TLHCEGTEINS(1)DDEQESK;TLHCEGT(0.002)EINS(0.998)DDEQESK;TLHCEGTEINS(1)DDEQESK;TLHCEGTEINS(1)DDEQESK 210.34 7.7186e-12 1174378300.0 1028597.0 781721.0 923153.0 957627.0 1005664.0 825637.0 1003359.0 1078088.0 796550.0 789859.0 True False 971431.696540035 841676.4870708137 863758.3410329898 827196.5506012831 879323.4975697688 939361.0023635393 1050017.1816181398 1081225.057592924 955882.2574665712 767053.7183698602 1.266445456524894 1.0972849318292095 1.126072816475808 1.0784075884010291 1.1463649500826407 1.2246352241924672 1.368896540713775 1.4095819258796367 1.2461738136124398 1.0 19.548968090642234 -6.906698852706165 3.551153879847797 1.2911400815059404 1.135731669053681 0.155838504931208 0.11370319990539607 0.30451542219191663 7.523948416821408 0.040960594808003306 0.03547906672668046 1.2396558873695562e-07 6.906698852706165 -0.15540841245225945 TLHCEGTEINS(ph)DDEQESKEVEETATAK ddPTM_A459_Selumetinib_30min_R1 4 TLHCEGTEINSDDEQESKEVEETATAK 27 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 T(0.001)LHCEGT(0.131)EINS(0.858)DDEQES(0.01)KEVEETATAK;T(0.001)LHCEGT(0.251)EINS(0.698)DDEQES(0.05)KEVEETATAK;TLHCEGTEINS(0.996)DDEQES(0.004)KEVEETATAK;TLHCEGTEINS(1)DDEQESKEVEETATAK 113.67 1.0885e-10 321453000.0 5180.94 4895.860000000001 6986.759999999999 7045.39 5856.360000000001 5053.719999999999 4661.34 4859.93 2970.0 4066.2299999999996 True False 5301.645821645659 4322.650435176438 6037.996367525549 5815.044894849775 5326.653272024335 5002.884165210623 4309.731370933638 4731.028869122549 5039.873079782526 4588.170228934293 1.15550329589168 0.9421294807059658 1.3159922292002693 1.2673995524792139 1.1609537149325804 1.09038765250274 0.9393137472875915 1.0311362990168387 1.098449453335377 1.0 12.163703203453355 -6.939266607788077 3.7217958672594906 1.018842452519515 1.1690239555834132 0.34351183115384465 0.09825344997534613 0.2921162175069878 8.2523714269534 0.039390163216877216 0.03367605489831367 1.1500941442091485e-07 6.939266607788077 0.15018150306389821 TLHCEGTEINS(ph)DDEQESKEVEETATAK ddPTM_A459_Selumetinib_30min_R2 7 TLHCEGTEINSDDEQESKEVEETATAK 27 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 TLHCEGTEINS(1)DDEQESKEVEETATAK;TLHCEGTEINS(1)DDEQESKEVEETATAK;T(0.001)LHCEGT(0.132)EINS(0.859)DDEQES(0.008)KEVEETATAK;TLHCEGT(0.257)EINS(0.743)DDEQESKEVEETATAK;TLHCEGTEINS(1)DDEQESKEVEETATAK;TLHCEGTEINS(1)DDEQESKEVEETATAK;TLHCEGT(0.165)EINS(0.834)DDEQESKEVEETATAK 142.54 5.5632e-13 418770000.0 612519.0 602997.0 624189.0 592811.0 588985.0 396530.0 374770.0 355878.0 225507.0 595308.0 True False 578477.6460878325 649244.9309590497 584029.3593055984 512069.11914398446 514991.438707293 451148.40815905115 392197.5475926669 356913.5460612258 270614.70119203354 578119.9112440608 1.0006187900413288 1.1230281440435677 1.0102218379727157 0.8857489755750824 0.8908038430973236 0.7803716830790715 0.6784017294071292 0.6173694057573293 0.4680944142015375 1.0 19.141009236046713 -6.467154005502133 0.9632478575061086 0.6565780730421865 1.059732359458585 0.5434761034573914 0.13212703172072174 0.37833753293662853 0.7589355513994563 0.0659070894819113 0.08262454429848833 3.410719423894068e-07 6.467154005502133 0.4031542864163985 TLHS(ph)PPLQLQQR ddPTM_A459_Selumetinib_30min_R2 3 TLHSPPLQLQQR 12 0 A0A2R8YGT1;F8W9A8;B7WPL9;Q6PFW1-7;Q6PFW1-4;Q6PFW1-3;Q6PFW1-2;Q6PFW1 A0A2R8YGT1 PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 1 T(0.003)LHS(0.997)PPLQLQQR;T(0.003)LHS(0.997)PPLQLQQR;T(0.021)LHS(0.979)PPLQLQQR 82.705 0.023978 25006600.0 122395.0 106297.0 118646.0 155754.0 150638.0 98524.0 101971.0 114615.0 85416.0 132816.0 True False 115592.77588600536 114449.63810127445 111012.44553199755 134540.03650936362 131713.50771919338 112094.78668817582 106712.85355170314 114948.51067446537 102501.58672244611 128981.2569825893 0.8961982429866442 0.8873354220506905 0.8606866464868047 1.0430975760107895 1.0211833160919876 0.8690781072424119 0.8273516326958104 0.8912032132698308 0.7947014094945781 1.0 16.976801908900242 -6.944006058361185 24.996585529442406 0.8662425008892052 0.9403444090157923 0.1593943460849918 0.07303565647094046 149.76609244215737 66857.1787092889 0.026649791080261654 0.023502903923813878 1.1376114161561738e-07 6.944006058361185 0.07410190812658712 TLHSCSVR ddPTM_A459_Selumetinib_30min_R2 1 TLHSCSVR 8 0 E9PP73;P53618 E9PP73 COPB1 Coatomer subunit beta 0 122.19 0.006603399999999999 0.0 2856.3 2293.2 2313.6 3584.1 3955.9 3479.5 5997.0 4820.1 2824.6 4645.8 False True 2697.558280674844 2469.0810661998194 2164.7454948572167 3095.939397082641 3458.924475805293 3958.769541243838 6275.872382830061 4834.12569298949 3389.5989259181165 4511.663682761971 0.5979076611985936 0.5472662059527198 0.4798109183377766 0.68620793010603 0.7666627477178867 0.8774522702943008 1.3910328482171055 1.0714729715912938 0.7512968971665583 1.0 12.139443812218053 -6.58795887842927 1.7069805757763221 1.0588966412899774 0.559478543472907 0.6482914477319935 0.15576180726066086 0.22841225724263736 1.3615663713718222 0.06479648225022829 0.06744613304363813 2.582504705881377e-07 6.58795887842927 -0.49941809781707036 TLHSDDEGTVLDDSR ddPTM_A459_Selumetinib_30min_R1 1 TLHSDDEGTVLDDSR 15 0 O00170;E9PMH2 O00170 AIP AH receptor-interacting protein 0 193.98 4.4714e-05 6980400.0 1814.4 2215.3 1936.3 1965.3 1862.5 2010.8 2073.3 1410.0 991.26 1790.7 False True 1856.6719897921776 1955.9316461349706 1673.3610953345649 1622.097248250028 1694.0372038510816 1990.5731776603225 1916.9093117765947 1372.6022196745203 1682.0958212340827 2020.5537878950877 0.9188926327600345 0.9680176087628742 0.828169537163269 0.8027983506144859 0.8384024290765578 0.9851621815690452 0.9487049160782477 0.6793198121711123 0.832492473752162 1.0 10.980535041774466 TLHSDDEGTVLDDSR ddPTM_A459_Selumetinib_30min_R2 2 TLHSDDEGTVLDDSR 15 0 O00170;E9PMH2 O00170 AIP AH receptor-interacting protein 0 ; 198.81 2.9528000000000006e-05 9414300.0 43470.0 43412.0 46140.0 51978.0 52946.0 39310.0 41137.0 40935.0 35241.0 45968.0 False True 41054.11142419754 46741.56080841903 43171.40263343359 44898.5067329487 46294.45013675448 44724.59567934912 43049.95201141906 41054.114072845936 42290.184715811185 44640.784400792625 0.9196547949428191 1.0470595764797785 0.9670843201551595 1.0057732482888786 1.037043832409282 1.0018774598090396 0.9643636999052078 0.9196548542752979 0.9473441222744351 1.0 15.446074757101657 -7.377456325743487 4.144917523817783 0.9489631794774749 0.9995822433499859 0.1877633011238018 0.03828416274046203 0.31373241599425966 9.129855291891484 0.016181262963347064 0.010552072907770308 4.193181627469487e-08 7.377456325743487 0.05061906387251103 TLLISSLS(ph)PALPAEHLEDR ddPTM_A459_Selumetinib_30min_R1 1 TLLISSLSPALPAEHLEDR 19 0 Q8NDT2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 TLLIS(0.014)S(0.162)LS(0.824)PALPAEHLEDR 113.08 0.00036082 4225400.0 2412.5 2884.0 3347.1 3816.3 3283.2 2698.6 2781.6 2991.0 1619.4 2639.6 True False 2468.7065560921674 2546.3399392647743 2892.5822043042504 3149.854845823327 2986.23513969604 2671.4545341327566 2571.781672520993 2911.6689638627595 2748.003523703644 2978.418371881316 0.828864936974187 0.8549302419378982 0.9711806211016462 1.0575595677089928 1.0026244693789563 0.8969373004657281 0.8634722699808385 0.977588975192765 0.922638521722477 1.0 11.54033070501744 -5.205837191431906 4.984124898750013 0.9598306543348404 0.837561874661943 0.4485810418968478 0.053170111872086624 0.21329006145307217 11.449063308191283 0.01528678875051667 0.0421875477378472 6.22533617195274e-06 5.205837191431906 -0.1222687796728974 TLLPWDS(ph)DESPEASPGPPGPR ddPTM_A459_Selumetinib_30min_R1 1 TLLPWDSDESPEASPGPPGPR 21 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 T(0.001)LLPWDS(0.975)DES(0.021)PEAS(0.003)PGPPGPR 73.76 0.024349000000000003 0.0 379.51 506.38 464.62 524.04 548.64 669.26 345.95 517.11 244.21 347.28 True False 388.3518446020886 447.09279419032447 401.52715597497587 432.52625144911434 499.0156088702594 662.5278520394601 319.85471297405724 503.394562989994 414.4065336073034 391.85677079365934 0.9910555936433817 1.1409597269042746 1.0246783669495625 1.1037865967534102 1.2734643014067681 1.6907398351126832 0.8162541438960708 1.2846391858189106 1.0575459313053905 1.0 8.614182614969025 -6.072547793035015 5.662123736936866 1.2073708386599333 1.0613300812019857 0.06848572671581454 0.21796687037166157 0.5937034886505368 34.4870417832072 0.06472371235882707 0.08515954703663085 8.461594459264035e-07 6.072547793035015 -0.14604075745794765 TLLSES(ph)PGK ddPTM_A459_Selumetinib_30min_R2 2 TLLSESPGK 9 0 Q9UPY3-3;Q9UPY3-2;Q9UPY3 Q9UPY3-3 DICER1 Endoribonuclease Dicer 1 TLLS(0.064)ES(0.936)PGK;TLLS(0.147)ES(0.853)PGK 107.11 0.012777 9187700.0 104511.0 69590.0 85574.0 99014.0 102745.0 95461.0 117449.0 114447.0 95750.0 76030.0 True False 98702.69701068108 74927.32923288237 80068.26200592653 85528.12239132285 89837.25454804584 108609.8862413215 122910.61122077849 114780.02182227914 114902.67547853157 73834.8163503365 1.3368042596916574 1.0147967170035614 1.0844242047818355 1.1583711671402166 1.2167329586326843 1.4709847143924872 1.6646701014001821 1.5545514636030653 1.5562126535716356 1.0 16.172013650190607 -6.704368548324059 3.3393076438895304 1.5012567069866312 1.1392565963254322 0.3650393212307941 0.18491091378175512 0.21480256319202506 4.863337736485947 0.06251595456783869 0.0602503663122 1.9752926678923908e-07 6.704368548324059 -0.36200011066119897 TLLSESS(ph)SQSSKSPSLSSK ddPTM_A459_Selumetinib_30min_R1 1 TLLSESSSQSSKSPSLSSK 19 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 T(0.044)LLS(0.056)ES(0.04)S(0.49)S(0.138)QS(0.005)S(0.004)KS(0.171)PS(0.05)LSSK 83.064 0.0026199 121580000.0 3365.7 3800.6 5600.1 5446.3 4344.0 4241.5 3877.7 3813.9 2163.3 2705.8 True False 3444.1142614878368 3355.623985148996 4839.637179147397 4495.205944712831 3951.0859669954916 4198.834360973867 3585.2019670458176 3712.7429827068454 3670.9620988193738 3053.115786723924 1.1280653935445615 1.0990817969434665 1.5851469505977887 1.4723339233512363 1.2941159926447185 1.3752620779178932 1.1742764498600418 1.2160505012129657 1.202365830599047 1.0 11.57606658818151 -8.428419203612204 0.7496853575300232 1.0088886902027612 1.327841939128533 0.30995230170633037 0.14108905522261372 0.9038663300369668 1.1560389325482536 0.14948671769552516 0.058074524375631396 3.7289005116352205e-09 8.428419203612204 0.3189532489257718 TLLSESSSQSSKS(ph)PSLSSK ddPTM_A459_Selumetinib_30min_R2 1 TLLSESSSQSSKSPSLSSK 19 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 T(0.015)LLS(0.058)ES(0.051)S(0.051)S(0.011)QS(0.022)S(0.035)KS(0.477)PS(0.251)LS(0.023)S(0.005)K 55.302 0.03179 122340000.0 104470.0 78354.0 116490.0 100490.0 101520.0 73176.0 62809.0 70174.0 47262.0 73704.0 True False 98663.97562654509 84363.49985218082 108995.16022472233 86803.0886450811 88766.14999968477 83255.3297744098 65729.74295367229 70378.19472206892 56715.72061061457 71575.97401401024 1.3784510373164138 1.1786566793442106 1.5227897590801585 1.212740585662031 1.2401668468012708 1.1631742483603988 0.9183213202352845 0.9832656235777264 0.7923848943992444 1.0 16.127187777266165 -7.012141643291881 1.2845837490901915 0.9006681650662746 1.3278425477600728 0.7573768616359695 0.10271855383101607 0.20807215314032879 0.6996757944399609 0.05446340087611134 0.03910920343729124 9.724300181516613e-08 7.012141643291881 0.42717438269379826 TLLSESSSQSSKSPS(ph)LSSK ddPTM_A459_Selumetinib_30min_R1 1 TLLSESSSQSSKSPSLSSK 19 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 T(0.004)LLS(0.001)ES(0.007)S(0.007)S(0.007)QS(0.057)S(0.122)KS(0.3)PS(0.436)LS(0.041)S(0.016)K 65.881 0.012802 125780000.0 2951.7 3484.2 4066.3 4443.6 2854.3 2992.7 3543.0 3123.3 1708.8 2378.2 True False 3020.468866991607 3076.2682442393652 3514.118794587071 3667.608676702705 2596.1290689675943 2962.5961551541895 3275.748657514335 3040.4599380917934 2899.7087941859854 2683.4651356296945 1.1255852840744405 1.1463790616819385 1.3095451652896015 1.366743554073444 0.9674539961401041 1.1040188731421676 1.2207159370250795 1.133035006761259 1.0805837406587167 1.0 11.389881428975453 -6.261356910299935 24.99999999977703 1.0987596273539035 1.2357630961753667 0.3886131947710513 0.09280579147035405 9.578877358871601 2903706.0651153033 0.03018023842687348 0.03654602776248492 5.478265670518504e-07 6.261356910299935 0.1370034688214632 TLLSESSSQSSKSPS(ph)LSSK ddPTM_A459_Selumetinib_30min_R2 1 TLLSESSSQSSKSPSLSSK 19 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 TLLS(0.006)ES(0.005)S(0.022)S(0.014)QS(0.004)S(0.004)KS(0.217)PS(0.724)LS(0.004)S(0.001)K 78.166 0.004218199999999999 111780000.0 77516.0 60426.0 75500.0 82992.0 75830.0 50715.0 52452.0 57537.0 38916.0 72023.0 True False 73207.97104113399 65060.47989978648 70642.41219818448 71688.34643081474 66303.55747119882 57700.530905067135 54891.121931666225 57704.42314423687 46700.28740389057 69943.50885177279 1.0466728398811016 0.9301861025826624 1.0099923975488967 1.024946383269671 0.9479586963775594 0.8249590541325074 0.7847922249367527 0.8250147024583296 0.667685796302553 1.0 16.093902552995317 -6.702196406282313 3.000360412215224 0.8042346915783837 0.9977003296509607 0.5319538480654402 0.08110546550240096 0.1866751504045822 3.417382536068584 0.027601481899112473 0.02656141479152945 1.9851969245369975e-07 6.702196406282313 0.193465638072577 TLLTGDGGGEAT(ph)GSPLAQGK ddPTM_A459_Selumetinib_30min_R1 1 TLLTGDGGGEATGSPLAQGK 20 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H0Y7E2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 TLLTGDGGGEAT(0.765)GS(0.235)PLAQGK 327.02 2.4110999999999984e-136 16079000.0 2045.4 2310.5 2634.2 2726.5 2517.0 1903.9 2662.3 2507.6 1143.1 1566.7 True False 2093.053840344422 2039.9855858776918 2276.490108624857 2250.367957743703 2289.3377944124436 1884.7484946028871 2461.4805675699736 2441.090302167255 1939.7572112792618 1767.8012059503174 1.1839871096927206 1.1539677532808652 1.287752322468342 1.2729756887647172 1.2950199302425318 1.0661540948489752 1.3923967012154825 1.380862448758766 1.0972711211815844 1.0 10.787740333534698 -8.491866375137183 6.58868280615917 1.0001220326140983 1.2519153583064935 0.44880842719756964 0.09418114160657574 0.15278209119266473 22.392460179764154 0.09341205294513825 0.0241838645785694 3.2220600106418998e-09 8.491866375137183 0.2517933256923952 TLLTGDGGGEAT(ph)GSPLAQGK ddPTM_A459_Selumetinib_30min_R2 1 TLLTGDGGGEATGSPLAQGK 20 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H0Y7E2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 TLLTGDGGGEAT(0.849)GS(0.151)PLAQGK 240.82 8.9851e-30 6671200.0 30963.0 31410.0 34927.0 39312.0 35055.0 33770.0 29449.0 28688.0 27025.0 37113.0 True False 29242.200414709656 33819.04600093159 32679.834845642275 33957.63778301743 30651.077504323806 38421.51096646194 30818.43685208646 28771.477330445945 32430.75514159069 36041.451258845635 0.8113491380992256 0.9383375202637378 0.9067291605695728 0.9421828643674061 0.8504396031167343 1.0660367333857614 0.8550831272234829 0.7982885351594874 0.8998182373033945 1.0 15.137369483980194 -4.752111384230558 24.731020881978335 0.9121721052010104 0.8113489104851005 0.156632120113254 0.07293497506178327 671.3483568180554 1779778.9526398394 0.018186895159065925 0.22238454151728457 1.7696550337306737e-05 4.752111384230558 -0.10082319471590995 TLLTGDGGGEATGS(ph)PLAQGK ddPTM_A459_Selumetinib_30min_R2 2 TLLTGDGGGEATGSPLAQGK 20 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;H0Y2S9;H0Y7E2 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 TLLTGDGGGEAT(0.081)GS(0.919)PLAQGK;TLLTGDGGGEAT(0.083)GS(0.917)PLAQGK 247.18 8.404799999999998e-38 18069700.0 104940.0 107431.0 116679.0 126928.0 130755.0 84891.0 100499.0 106133.0 94007.0 122140.0 True False 99107.85490810419 115670.61225488977 109172.00017048964 109640.18743698733 114328.38793546883 96583.96468622804 105172.40263499065 106441.829458736 112811.02677504237 118613.50084216839 0.8355529025315663 0.9751892612022763 0.9204011296804909 0.924348296429415 0.9638733122597781 0.8142746314750993 0.8866815487971899 0.8973837607269641 0.9510808295351891 1.0 16.855908704299743 -8.519222810063603 3.071359709845518 0.999671128452302 0.9047293332566827 0.3014162208090977 0.04742027115974149 0.3039715017185848 7.131195826663211 0.04597969174253208 0.012250075713761766 3.025360901354016e-09 8.519222810063603 -0.0949417951956193 TLMLPLTEGS(ph)LR ddPTM_A459_Selumetinib_30min_R1 2 TLMLPLTEGSLR 12 0 Q7L4E1-3;Q7L4E1 Q7L4E1-3 FAM73B Protein FAM73B 1 TLMLPLTEGS(1)LR;TLMLPLTEGS(1)LR 168.61 0.00038155 26169000.0 3713.5 6471.700000000001 6062.1 6515.1 5163.799999999999 5851.6 4968.5 5490.8 2388.3 3835.2999999999997 True False 3800.0173247868465 5713.990355388297 5238.900116731741 5377.36008857363 4696.735201742934 5792.738216827698 4593.722044837702 5345.166147367982 4052.7706654695653 4327.598113985609 0.8780892367307014 1.3203606723374446 1.2105791662587737 1.24257381275666 1.085298375226751 1.3385573392564245 1.0614946036675756 1.235134595815141 0.9364942304536372 1.0 12.07935081296709 -8.265449387947573 24.97185144619257 0.9682470888267072 1.1791709137278614 0.2799716030985304 0.12992434945324602 418.7996857084555 2607969.037721004 0.1026980633357914 0.03033819807736448 5.4268849177794094e-09 8.265449387947573 0.21092382490115424 TLMLRS(ph)NLIGCVSNDT(ph)FAGLS(ph)SVR ddPTM_A459_Selumetinib_30min_R2 1 TLMLRSNLIGCVSNDTFAGLSSVR 24 1 A0A0A0MSC8;O75094-2;O75094-3;O75094;O75094-4 A0A0A0MSC8 SLIT3 Slit homolog 3 protein 3 T(0.111)LMLRS(0.889)NLIGCVS(0.286)NDT(0.781)FAGLS(0.724)S(0.209)VR 62.377 0.013169 0.0 7651.7 8284.4 8716.9 9976.6 11188.0 6993.8 8680.4 6852.5 7267.5 9935.1 True False 7226.449146182017 8919.786841455516 8156.064144243121 8617.769869405061 9782.463418010972 7957.132466604726 9084.055799886286 6872.439640507559 8721.203070916203 9648.247848510155 0.7489908281427387 0.924498103853424 0.8453414829618571 0.8931953246553243 1.0139108749700643 0.8247230576516995 0.9415238852191189 0.7122992431800738 0.9039157376396479 1.0 13.236051252972198 -4.751905057548464 24.682052515758464 0.8877880310890686 0.7489905028062156 0.2125125497872341 0.08342555579196553 541.9965106339052 1402980.6561930256 0.020159512258511092 0.2502709415007807 1.770495969578725e-05 4.751905057548464 -0.13879752828285297 TLMNAVS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 TLMNAVSPLK 10 0 E7EQI7;Q12768 E7EQI7 KIAA0196 WASH complex subunit strumpellin 1 T(0.015)LMNAVS(0.985)PLK;TLMNAVS(1)PLK 93.348 0.025346 9417000.0 69809.0 70365.0 73824.0 78687.0 80481.0 60985.0 65218.0 79002.0 52092.0 73404.0 True False 65929.2952475685 75761.76924086448 69074.24421349386 67969.6948573537 70370.25727073115 69385.13018328928 68250.76622701524 79231.88274051493 62511.85557209037 71284.63579350372 0.9248738457267497 1.062806429429338 0.9689920337614841 0.9534971189899504 0.9871728527109077 0.9733532255713994 0.9574400635884995 1.1114861128004172 0.8769330848960747 1.0 16.12130354102804 TLNAETPKSS(ph)PLPAK ddPTM_A459_Selumetinib_30min_R1 1 TLNAETPKSSPLPAK 15 1 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 TLNAETPKS(0.01)S(0.99)PLPAK 196.37 0.00015037 39258000.0 5245.2 4259.2 8880.0 8502.0 7462.2 5786.6 4589.5 5348.1 3188.2 4430.9 True False 5367.402954617468 3760.530883951639 7674.144774348471 7017.2853023058715 6787.245327558416 5728.392057812425 4243.310319972352 5206.251014922909 5410.142543085063 4999.649175620899 1.0735559168410849 0.7521589519297871 1.5349366535093796 1.4035555407613987 1.3575443174401367 1.1457588035866586 0.8487216144411536 1.0413232673023207 1.0821044343402726 1.0 12.28761114947962 -7.011138641118629 23.229103231304926 0.9965893489645729 1.2279604385875387 0.21989562327025458 0.205737279538065 366.2349581936692 763766.0950168594 0.0828051240955099 0.06823630440785165 9.746784385518238e-08 7.011138641118629 0.23137108962296582 TLNAETPKSS(ph)PLPAK ddPTM_A459_Selumetinib_30min_R2 1 TLNAETPKSSPLPAK 15 1 Q7L2J0 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 1 TLNAETPKS(0.091)S(0.909)PLPAK 203.52 4.4132e-05 7616800.0 55371.0 56396.0 57996.0 65578.0 56852.0 39312.0 31958.0 37903.0 27094.0 55697.0 True False 52293.70148767525 60721.391858278796 54264.60050127036 56646.16327164011 49709.743496671406 44726.871161194904 33444.11032357562 38013.291454820566 32513.557069611783 54088.8828918149 0.96681052911131 1.12262240615562 1.0032486825399394 1.0472792234393178 0.9190380876620734 0.8269143078930787 0.6183176382190843 0.7027930588038267 0.6011134882309052 1.0 15.723044481088161 -6.728226089760002 1.902570253406995 0.7069487409759462 1.0387047815682933 0.5977567450723438 0.11093840980705362 0.20140399885926175 1.5033666237310153 0.04204482936327961 0.039451064890434165 1.8697085336934245e-07 6.728226089760002 0.3317560405923471 TLNDELEIIEGMKFDR ddPTM_A459_Selumetinib_30min_R1 2 TLNDELEIIEGMKFDR 16 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 ; 159.4 0.00017426 12196300.0 3063.7 2920.2 6884.7 8139.5 5293.299999999999 5147.4 3521.4 3931.5 2446.7 2228.6000000000004 False True 3135.078249077542 2578.30162643585 5949.7955549501 6718.089122338119 4814.521949608015 5095.621829465255 3255.777962904593 3827.22384868821 4151.871200102326 2514.6625184022973 1.2467192818658739 1.0253072162040995 2.3660413719175053 2.6715668894633575 1.9145797554842248 2.026364091473707 1.294717656575709 1.5219632140219972 1.651064971827805 1.0 11.296149080041943 -7.26243039653507 24.990780896427985 1.4104333843064354 1.8967832341287612 0.21149332994550107 0.47663850507703215 174.33513913868228 4396167.58342572 0.2139395022802142 0.15357178150926803 5.464741251247749e-08 7.26243039653507 0.48634984982232576 TLNGVSS(ph)PPHPSPK ddPTM_A459_Selumetinib_30min_R1 1 TLNGVSSPPHPSPK 14 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 TLNGVS(0.011)S(0.989)PPHPSPK 124.78 0.0018448 0.0 918.66 896.81 935.7 1133.7 1373.1 747.46 1051.9 946.52 262.01 645.47 True False 940.0629905988105 791.8110682843425 808.6370794321917 935.7205771846824 1248.9033474404953 739.9412310393791 972.554336110451 921.4152148697361 444.6118335467405 728.3223619102264 1.290723778044156 1.0871711616921929 1.1102735845035951 1.284761564550204 1.714767268939679 1.0159529210371614 1.3353349930924252 1.265120038952354 0.6104602258546934 1.0 9.508433331121825 -8.2454699609005 24.323635830189904 0.8052301505190099 1.2620192805207981 0.4549347716386394 0.20043069524094903 439.22053781955765 668997.242053459 0.13649327036517997 0.05118514918691183 5.682376938283577e-09 8.2454699609005 0.4567891300017882 TLNGVSS(ph)PPHPSPK ddPTM_A459_Selumetinib_30min_R2 2 TLNGVSSPPHPSPK 14 0 Q9BZL4-3;K7EL81;Q9BZL4-5;Q9BZL4-2;Q9BZL4-4;Q9BZL4 Q9BZL4-3;Q9BZL4-5 PPP1R12C Protein phosphatase 1 regulatory subunit 12C 1 TLNGVS(0.029)S(0.971)PPHPSPK;TLNGVS(0.026)S(0.974)PPHPSPK 169.15 0.00018309 11754100.0 46546.1 43951.2 65870.0 81902.0 87337.0 52918.0 46445.6 52781.0 57875.0 69567.0 True False 43959.2541008015 47322.11571461777 61631.99591383338 70746.80631116939 76364.94525731349 60206.97415822424 48605.41243021045 52934.58397163509 69451.61716261093 67558.41995322688 0.6506850534875752 0.7004621444281937 0.9122770478720997 1.0471945075114242 1.1303542224667729 0.8911838701957164 0.7194575075003489 0.783537921820605 1.0280231125993589 1.0 16.043847966535694 -5.241494509660825 3.987750411105816 0.9338010476126221 0.6645651398534108 0.45297558762033074 0.11638193484615315 0.22131786063966105 8.186763760304883 0.03473912655740842 0.09473973821654695 5.734631162054512e-06 5.241494509660825 -0.26923590775921125 TLNMT(ph)TSPEEK ddPTM_A459_Selumetinib_30min_R2 1 TLNMTTSPEEK 11 0 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 1 TLNMT(0.535)T(0.233)S(0.233)PEEK 97.452 0.044962 106230000.0 126010.0 116540.0 128390.0 136730.0 113760.0 83914.0 102850.0 107370.0 77456.0 101800.0 True False 119006.86865799717 125478.24326483817 120129.52718046239 118107.13812759393 99468.45177269647 95472.39180455099 107632.7287934087 107682.42892393966 92949.36430146353 98860.7694918354 1.2037825445797847 1.269242025019854 1.2151385003166855 1.1946815580607841 1.006146849594482 0.9657257605347261 1.0887304372266469 1.089233165768883 0.9402047422778752 1.0 16.593110515419554 -6.191107400412183 4.098425191290883 1.0203251218106195 1.2289942067798627 0.8209226393531655 0.047156443650668754 0.09830020480770059 3.225525616451351 0.014903916299137527 0.019339464521638563 6.440099830613093e-07 6.191107400412183 0.2086690849692432 TLNMTT(ph)SPEEK ddPTM_A459_Selumetinib_30min_R1 1 TLNMTTSPEEK 11 0 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 1 TLNMT(0.034)T(0.517)S(0.449)PEEK 185.57 4.4448e-05 19527000.0 4313.5 4945.6 5685.3 5930.2 4071.5 4608.3 5099.0 4229.5 2847.3 3875.5 True False 4413.996157390082 4366.566852852938 4913.267487117497 4894.601893640826 3703.2335438817067 4561.944686001622 4714.378324771547 4117.319920647789 4831.660141435955 4372.958175566766 1.0093844898980762 0.9985384441247257 1.1235569355704398 1.1192885221241458 0.846848608013897 1.043217086202834 1.0780753292159102 0.9415411159550264 1.1048951184651423 1.0 12.09439383472974 -6.877801398393879 0.006738255150451967 0.5154736408274452 1.5364509149441694 0.004005669032223325 0.08252924588438915 45889.61109192855 132.25123511119602 9851.885065774304 10182.123231986277 1.3249472912297544e-07 6.877801398393879 1.0209772741167242 TLNMTT(ph)SPEEK ddPTM_A459_Selumetinib_30min_R2 1 TLNMTTSPEEK 11 0 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 1 TLNMT(0.179)T(0.619)S(0.202)PEEK 169.09 0.0010323 102700000.0 174540.0 143860.0 152620.0 158840.0 139100.0 113120.0 134880.0 116430.0 90048.0 117440.0 True False 164839.7655389795 154893.5994171923 142800.59536009163 137205.71798571688 121625.01443022225 128701.25319888008 141152.1872596496 116768.79202397575 108060.11615134001 114049.20205423505 1.44533905165414 1.3581296197366999 1.2520964003955426 1.2030397014129917 1.0664258253414574 1.1284713165961247 1.2376429182952633 1.0238457606081928 0.9474868232743358 1.0 16.799296827299706 -1.5228787452814738 0.24508122668366553 0.9828403187208323 3.9458517768220265 0.8226502214377971 0.06465340581808787 21.887812305374375 0.2951581682128592 0.09337472822428897 26.559521468532083 0.02999999999992151 1.5228787452814738 2.963011458101194 TLNMTTS(ph)PEEK ddPTM_A459_Selumetinib_30min_R1 4 TLNMTTSPEEK 11 0 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 1 TLNMT(0.022)T(0.252)S(0.726)PEEK;TLNMT(0.003)T(0.158)S(0.838)PEEK;TLNMT(0.022)T(0.076)S(0.902)PEEK;TLNMT(0.159)T(0.159)S(0.682)PEEK 185.2 2.084e-05 294561000.0 27042.100000000002 30365.5 34390.0 35838.7 26857.699999999997 26010.299999999996 26392.4 27102.200000000004 16957.0 24384.7 True False 27672.128315233174 26810.29314346204 29720.026890748166 29580.143820718604 24428.425777112043 25748.659997462823 24401.600019356858 26383.361615647365 28774.79050972132 27514.71377209211 1.0057211041497633 0.974398402452416 1.080150320185881 1.0750663832353378 0.8878313610476132 0.935814205110119 0.8868564005963656 0.9588819216577763 1.0457964690480368 1.0 14.747915700339888 -6.254792370541435 24.99351547906123 0.9463546797197583 1.0328969530053986 0.3568751940111464 0.05307664380399594 598.7719678347062 2251448.155542949 0.016673182355634683 0.0210277375582669 5.56170090017347e-07 6.254792370541435 0.08654227328564035 TLNPDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TLNPDSPR 8 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 TLNPDS(1)PR 86.189 0.034221 5025100.0 28966.0 29092.0 31616.0 37002.0 35289.0 34742.0 29822.0 27297.0 20667.0 32836.0 True False 27356.185680085262 31323.262854476332 29581.86098089807 31962.263767989705 30855.680332337233 39527.395143524474 31208.78209117193 27376.429750738378 24800.977484227733 31887.93936182619 0.8578850257359057 0.9822918470540669 0.9276817998566322 1.0023307999090243 0.9676285438900233 1.239571948974654 0.9787017510618043 0.8585198761231763 0.7777541597409575 1.0 14.960723251409686 -10.37605281072265 4.650425265068456 1.0000000859739224 0.9627595257683705 0.009187907157516495 0.11669291945126799 86360974.80274698 20.235051337842798 159.86763650592724 0.030080220302423515 4.2067547063931364e-11 10.37605281072265 -0.03724056020555189 TLPGACGS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 TLPGACGSPQK 11 0 Q9UBZ9-2;Q9UBZ9 Q9UBZ9-2 REV1 DNA repair protein REV1 1 TLPGACGS(1)PQK;TLPGACGS(1)PQK 133.04 0.0018966 16192100.0 74436.0 66800.0 71283.0 68999.0 74369.0 58466.0 68835.0 55652.0 46064.0 63943.0 True False 70299.14511091719 71923.34520414607 66696.72938706206 59601.21717008594 65026.101352704565 66519.1607984946 72035.96389396487 55813.93810631544 55278.087135697846 62096.79944613383 1.1320896686776671 1.1582456075942582 1.0740767637294812 0.9598114186510901 1.0471731543766885 1.0712172187907523 1.1600592065369297 0.8988214948941372 0.8901922100453677 1.0 15.922231291438315 -1.5228787452922672 0.21451403892537524 0.9527588604234329 2.0131038085787942 0.3462817404003702 0.07647370551944893 64.11139501237355 0.8080448078361401 0.1367671966345724 23.34546190217396 0.02999999999917593 1.5228787452922672 1.0603449481553613 TLPMS(ph)PPSER ddPTM_A459_Selumetinib_30min_R2 1 TLPMSPPSER 10 0 O15062 O15062 ZBTB5 Zinc finger and BTB domain-containing protein 5 1 TLPMS(0.969)PPS(0.031)ER 107.11 0.011488 3182800.0 21965.0 24650.0 26508.0 26096.0 25558.0 20716.0 21639.0 18510.0 14942.0 23595.0 True False 20744.273232861713 26540.575737757503 24802.504139728182 22541.67978188905 22347.17554858102 23569.440958875508 22645.256376865043 18563.86103550455 17930.817514362545 22913.75104282765 0.90531983148848 1.1582815789588978 1.082428804143429 0.9837620972557847 0.9752735598293071 1.0286155642881132 0.9882823783211763 0.8101624653600885 0.782535233137883 1.0 14.483926030593338 -7.654272857816452 4.822527259488543 0.8481223810309573 1.0257892173551797 0.41673100767720295 0.08290168505570412 0.18218523599870318 6.918795855780601 0.0406910605899239 0.022572665655691108 2.2168032127410455e-08 7.654272857816452 0.17766683632422242 TLPS(ph)PIDAK ddPTM_A459_Selumetinib_30min_R2 1 TLPSPIDAK 9 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 T(0.007)LPS(0.993)PIDAK 98.754 0.019417 8003900.0 124110.0 129200.0 141230.0 139510.0 142860.0 115320.0 114290.0 119760.0 99730.0 124500.0 True False 117212.46305169456 139109.2245565225 132143.4155595976 120508.49733182648 124912.6496153958 131204.2832292684 119604.71146133852 120108.48177266476 119678.78668902272 120905.36151015201 0.9694562886845397 1.1505629098577401 1.0929491786722954 0.9967175634449246 1.033144006644464 1.0851816792115676 0.9892424121431184 0.9934090620338591 0.9898550832997898 1.0 16.883518696299298 -7.276065230961059 23.920915152802408 0.9925773825466353 1.057154932929397 0.2842998178905136 0.04773505045888863 613.3717098835798 1003176.9906542018 0.020246157958970286 0.013731731690185309 5.2958389450220886e-08 7.276065230961059 0.0645775503827617 TLPSGSPRPGQLERPTSLALDS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 TLPSGSPRPGQLERPTSLALDSR 23 2 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 TLPS(0.001)GS(0.001)PRPGQLERPT(0.297)S(0.297)LALDS(0.403)R 52.19 0.037213 18618000.0 816.67 987.69 967.39 1013.2 1146.6 756.4 1114.9 953.49 745.42 762.46 True False 835.696822036804 872.0507956353767 836.023751492901 836.2636401195385 1042.890232448672 748.7913027562504 1030.8021953888604 928.2003478279848 1264.92329667727 860.3291679893275 0.9713686959956365 1.0136245847312648 0.9717487010777159 0.9720275346167416 1.2121990875725013 0.870354430161014 1.1981486083959525 1.078889781218599 1.4702782885224246 1.0 9.748744940480499 -7.295088830590967 23.89004270549022 1.1934034227022217 1.0092531349800065 0.2982996588275242 0.13853774035923966 472.7878717063219 335661.9787735557 0.054947851288093395 0.03704915785010757 5.068870190026533e-08 7.295088830590967 -0.1841502877222152 TLPSTSSS(ph)GSKR ddPTM_A459_Selumetinib_30min_R1 1 TLPSTSSSGSKR 12 1 A0A286YEX4;P08651-5;P08651-3;P08651-6;P08651-2;P08651;P08651-4 A0A286YEX4 NFIC Nuclear factor 1 C-type 1 TLPS(0.032)T(0.02)S(0.036)S(0.242)S(0.67)GSKR 152.16 0.00090349 7271800.0 3614.9 4088.0 4702.2 4907.9 4254.3 3953.0 4290.0 4176.5 2528.9 3206.1 True False 3699.1201366290456 3609.37505954036 4063.667067335742 4050.8273976931337 3869.4993161576717 3913.23640903683 3966.401846101187 4065.7256528160524 4291.358596451861 3617.6341650586014 1.022524657788089 0.9977169870856447 1.1232940872200978 1.1197448975959445 1.069621509419538 1.081711480622707 1.096407670076539 1.1238631291371035 1.1862334334136149 1.0 11.820830806788942 -5.2586252687774575 24.99542013555947 1.1033563333400795 1.0101208144636378 0.38456425860167465 0.04538756106571698 226.96141284122683 2015890.0990467116 0.01140827074757585 0.02749337590379396 5.512831662166598e-06 5.2586252687774575 -0.09323551887644177 TLQPPES(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 TLQPPESPR 9 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 TLQPPES(1)PR;TLQPPES(1)PR 106.67 0.013035 58751000.0 4486.4 5745.799999999999 6245.2 6274.5 5855.6 5119.299999999999 5319.9 4828.5 3040.0 4582.299999999999 True False 4590.924390985241 5073.079064850048 5397.136142428047 5178.776361952268 5325.962013890145 5067.804489952498 4918.615659923939 4700.432494821576 5158.657967184804 5170.48284038178 0.8879101880253517 0.9811615706813679 1.0438360031438632 1.0016040129764507 1.0300705327351758 0.9801414387013612 0.951287493212289 0.9090896614356627 0.9977130040729227 1.0 12.336083296130358 -9.551575426067599 12.422982732989823 0.9999998700703088 0.9778127184658676 0.022208047098202677 0.04645164066495367 0.0 0.0 0.047712946334397315 0.011572089261538068 2.808177620337392e-10 9.551575426067599 -0.02218715160444118 TLQPPES(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TLQPPESPR 9 0 Q86UU1-3;Q86UU1-2;Q86UU1 Q86UU1-3 PHLDB1 Pleckstrin homology-like domain family B member 1 1 TLQPPES(1)PR 109.72 0.011267 30530000.0 149550.0 128270.0 154040.0 172360.0 204460.0 111950.0 136970.0 136870.0 105610.0 144740.0 True False 141238.60969608318 138107.8965469438 144129.23410607077 148884.27066241569 178773.90690440865 127370.09631908257 143339.37640090604 137268.26903995176 126734.9509899495 140560.9801203168 1.0048208939293561 0.9825479050354288 1.0253858075171334 1.059214801540046 1.27186013324169 0.9061554366656868 1.0197664834025133 0.9765745011343365 0.9016367905336706 1.0 17.10083663072635 TLQRLS(ph)SGFDDIDLPSAVK ddPTM_A459_Selumetinib_30min_R1 1 TLQRLSSGFDDIDLPSAVK 19 1 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 T(0.015)LQRLS(0.727)S(0.255)GFDDIDLPS(0.003)AVK 87.80799999999998 0.0018003 77762000.0 5550.7 5064.5 8557.0 8821.4 6509.3 5618.1 5001.0 4293.3 2892.0 3310.4 True False 5680.020510217949 4471.545985577826 7395.0064002364725 7280.908088186431 5920.534964310258 5561.587014826664 4623.770543671803 4179.427737396185 4907.512776677124 3735.322086026635 1.520624026363398 1.197097835901571 1.9797506694001705 1.9492048933138544 1.585013240614036 1.4889176587025397 1.2378505620623028 1.1188935361239376 1.313812480866243 1.0 11.867016932463516 -7.1457956484098775 2.0223696666766378 1.1599891976144028 1.6568316105867718 0.5217946380019769 0.2179159845349482 0.307998751297825 2.474244300681376 0.11331084724334227 0.07908800732021706 7.14832602088749e-08 7.1457956484098775 0.496842412972369 TLQRLS(ph)SGFDDIDLPSAVK ddPTM_A459_Selumetinib_30min_R2 1 TLQRLSSGFDDIDLPSAVK 19 1 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 T(0.002)LQRLS(0.499)S(0.499)GFDDIDLPSAVK 74.408 0.0054445 4283500.0 28335.0 41628.0 32906.0 34982.0 33176.0 27066.0 18288.0 16172.0 11718.0 40174.0 True False 26760.254133992126 44820.733744883146 30788.863785343863 30217.391252684047 29008.134282796927 30794.09581931475 19138.428236984513 16219.05784258127 14061.927428276036 39014.07223541252 0.6859128668373722 1.1488350530145377 0.7891732911028254 0.7745254345752749 0.7435300295688348 0.7893073974309041 0.49055192499522865 0.41572327402058434 0.36043218824801954 1.0 15.251706972303424 -7.18890559276221 3.9646328161512194 0.5170865758765614 0.8349037347132215 0.26610721973146945 0.2011082610232808 0.2603996462144056 7.936043017501925 0.07909052453115714 0.05903404531498497 6.472833073536284e-08 7.18890559276221 0.3178171588366602 TLQRLSSGFDDIDLPS(ph)AVK ddPTM_A459_Selumetinib_30min_R1 1 TLQRLSSGFDDIDLPSAVK 19 1 Q9Y446;Q9Y446-2;E9PKC4 Q9Y446 PKP3 Plakophilin-3 1 TLQRLS(0.222)S(0.368)GFDDIDLPS(0.409)AVK 110.6 0.00035687 125870000.0 5131.0 5242.6 7981.7 8763.5 6066.1 5625.9 4979.9 4417.4 3068.5 3551.7 True False 5250.542316811987 4628.79395478138 6897.82898033977 7233.119236268826 5517.422326056943 5569.308553908497 4604.262133659508 4300.236202262575 5207.020385627162 4007.595291487674 1.3101478405178268 1.155005338142093 1.7211890120220203 1.8048527134544552 1.3767413934676027 1.389688366422123 1.1488840061867485 1.0730215726614123 1.2992879786756724 1.0 11.968521109451705 -7.116895016956423 2.190077570904073 1.1298533108941469 1.4881886375176892 0.42689856713734364 0.18909475215124374 0.3510165742751441 3.3089241749811102 0.09461248123849898 0.06840499472195376 7.640204497471042e-08 7.116895016956423 0.3583353266235423 TLQTDSIDSFETQRT(ph)PR ddPTM_A459_Selumetinib_30min_R1 5 TLQTDSIDSFETQRTPR 17 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TLQTDSIDSFET(0.001)QRT(0.999)PR;TLQTDSIDSFETQRT(1)PR;TLQTDSIDSFETQRT(1)PR;TLQTDSIDSFETQRT(1)PR;TLQTDSIDSFET(0.029)QRT(0.97)PR 201.96 5.4805e-08 482655600.0 16463.4 20524.2 21291.5 22836.399999999998 21652.2 19460.4 19274.6 16918.8 9551.41 13423.0 True False 16846.965187800113 18121.217122558275 18400.231245837873 18848.451432319198 19693.762333006398 19264.646044629462 17820.70140393051 16470.058463992395 16208.045162614677 15145.972801092166 1.112306578722054 1.1964379812732509 1.2148596519670922 1.2444530093808202 1.3002639441942148 1.2719319054395966 1.176596685994674 1.0874216321585333 1.0701224263023847 1.0 13.886646622604468 -7.810585531267495 2.0383732218304043 1.0370282978649417 1.2264113112350976 0.7094530150865923 0.04958277911523538 0.20222315021058815 1.6297509555348415 0.040065222764587766 0.015835795787721128 1.5467298562984162e-08 7.810585531267495 0.18938301337015595 TLQTDSIDSFETQRT(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 TLQTDSIDSFETQRTPR 17 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TLQTDSIDSFET(0.119)QRT(0.881)PR;TLQTDSIDSFET(0.003)QRT(0.997)PR;TLQTDSIDSFETQRT(1)PR;TLQTDSIDS(0.004)FET(0.116)QRT(0.88)PR;TLQTDSIDSFET(0.001)QRT(0.999)PR 201.96 5.4805e-08 527677000.0 300112.0 298839.0 344149.0 352369.0 393962.0 270220.0 217561.9 261265.0 201274.3 324253.0 True False 283432.9764835237 321758.9903811644 322006.8280211 304375.7343295698 344468.97149503394 307440.3521870695 227678.95944072623 262025.2378952509 241534.7840738232 314890.97337952955 0.900098765746167 1.0218107776413046 1.0225978362135961 0.9666067307769854 1.093930917733405 0.9763390448684598 0.72304060353712 0.8321141602856903 0.7670425782027986 1.0 18.264492876409214 -7.136036430430092 6.3741955248483135 0.8173750362176092 1.0044395960433419 0.49958592212784936 0.08131280848692778 0.17671012150485688 8.43057802064895 0.0295393897958525 0.02283857274292442 7.310777550639867e-08 7.136036430430092 0.18706455982573267 TLS(ph)ADASVNTLPVVVSR ddPTM_A459_Selumetinib_30min_R1 2 TLSADASVNTLPVVVSR 17 0 Q92615;H0Y4V9;H0Y641 Q92615 LARP4B La-related protein 4B 1 T(0.001)LS(0.997)ADAS(0.002)VNTLPVVVSR;T(0.058)LS(0.942)ADASVNTLPVVVSR 185.2 5.846e-08 28282000.0 3399.2 3894.3 3766.1000000000004 4070.4 3521.1 3036.6000000000004 3230.0 3513.7 1657.04 2696.0 True False 3478.394746308184 3438.353545589048 3254.684305706504 3359.58105087107 3202.6171267006957 3006.0545610122 2986.3584995120823 3420.505261893873 2811.875854586812 3042.0578612638387 1.1434347750581795 1.1302722375440177 1.069895595067455 1.1043777613997503 1.0527798197007836 0.9881648206925686 0.9816902359218717 1.124405063246498 0.9243334554519628 1.0 11.570831878672728 -5.829225431706076 0.6602132446091875 1.004392246055701 1.1584032890084202 0.5155217747497376 0.04961717070200064 0.9965372434053898 0.7578647823498834 0.028207093935315185 0.09688115791901274 1.4817487457440111e-06 5.829225431706076 0.15401104295271906 TLS(ph)ADASVNTLPVVVSR ddPTM_A459_Selumetinib_30min_R2 2 TLSADASVNTLPVVVSR 17 0 Q92615;H0Y4V9;H0Y641 Q92615 LARP4B La-related protein 4B 1 T(0.378)LS(0.622)ADASVNTLPVVVSR;T(0.002)LS(0.998)ADAS(0.001)VNTLPVVVSR 108.14 0.0023718000000000003 6717900.0 55465.0 51159.0 51377.0 56931.0 58347.0 39353.0 44767.0 48260.0 31848.2 55456.0 True False 52382.47734398704 55082.73079788788 48071.45975504807 49176.89958854714 51016.92823120185 44773.51853903395 46848.75420412763 48400.42861012693 38218.72991305859 53854.84118800808 0.9726605108929577 1.0227999857170356 0.8926116704574406 0.9131379557293618 0.9473044039458024 0.8313740705822323 0.8699079445908662 0.8987201065389886 0.7096619184083454 1.0 15.716788418729303 -5.587536193415369 0.6890179839356578 0.8576910582553862 1.020752449050795 0.26327989250351747 0.07400081417860549 1.661371149425422 1.1849794525765458 0.03670620717300667 0.18226458410214247 2.5850193991560667e-06 5.587536193415369 0.16306139079540893 TLS(ph)DDLDEAAK ddPTM_A459_Selumetinib_30min_R2 2 TLSDDLDEAAK 11 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 1 T(0.021)LS(0.979)DDLDEAAK;TLS(1)DDLDEAAK 162.22 0.00062248 2887500.0 26838.0 22160.9 24484.0 26659.0 27001.0 23634.6 29149.0 28960.0 22353.4 23514.0 True False 25346.451401026316 23860.56977147548 22908.72609616361 23027.998210659905 23608.892987997333 26890.051616462588 30504.48625764774 29044.268805413903 26824.704606180712 22835.08972329092 1.1099781830580637 1.0449080805291782 1.0032247025855818 1.008447897061347 1.033886587444286 1.1775759124360157 1.335860144509716 1.2719139340972179 1.1747142197046214 1.0 14.478964837892498 -6.83371946549189 4.323433481015547 1.2226004073794554 1.036076088769705 0.4217071698960769 0.0865254280416887 0.17539088581592407 6.293637918322171 0.03037187391418117 0.02710533075567987 1.4664948241118998e-07 6.83371946549189 -0.1865243186097505 TLS(ph)DDLDEAAKEFQEK ddPTM_A459_Selumetinib_30min_R1 1 TLSDDLDEAAKEFQEK 16 1 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 1 T(0.178)LS(0.822)DDLDEAAKEFQEK 79.332 0.013662 4729800.0 534.08 615.65 829.95 1018.2 764.53 1126.5 832.5 822.82 393.33 512.19 True False 546.5230248612246 543.5694117920799 717.247348589022 840.3904839811623 695.3783964887344 1115.1684327801636 769.703854750405 800.996140703964 667.452282313421 577.9345756530879 0.9456486043314383 0.9405379686408725 1.2410528437038144 1.4541273690564185 1.2032130033108515 1.9295755605554161 1.3318183185019006 1.3859633502612438 1.1548924574363366 1.0 9.174762373291088 -5.383766470740646 2.9372627236308575 1.384213258380223 0.9338580941935701 0.31661467464029935 0.23237084263265956 0.2839966128789787 4.629206175810935 0.06290984086236458 0.15775967377021233 4.132696660281932e-06 5.383766470740646 -0.4503551641866528 TLS(ph)DESIYNSQR ddPTM_A459_Selumetinib_30min_R1 2 TLSDESIYNSQR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 T(0.002)LS(0.995)DES(0.003)IYNSQR;T(0.331)LS(0.669)DESIYNSQR 231.74 4.267e-10 38518100.0 2817.2 2920.2 3370.3 3839.9 3387.8999999999996 2704.2 3038.7 2854.0 1411.1399999999999 2478.7 True False 2882.835278683047 2578.30162643585 2912.6317717327292 3169.333548850193 3081.4650431823243 2676.9982032171483 2809.4884125285953 2778.3026489014755 2394.6015144122266 2796.865289582596 1.0307379799165377 0.9218540614162491 1.041391511626007 1.133173471262602 1.1017566897697109 0.9571423454637187 1.0045133110246733 0.9933630551495419 0.8561733464001039 1.0 11.449595053052027 -7.57057605682405 1.3965287197921201 0.9373905473177612 1.036924596176058 0.2505584634996634 0.06665402122348003 0.6660620148745718 2.4644052812228727 0.052635587932603554 0.02369922938019497 2.6879670654031713e-08 7.57057605682405 0.09953404885829686 TLS(ph)DESLCSGR ddPTM_A459_Selumetinib_30min_R1 2 TLSDESLCSGR 11 0 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.011)LS(0.92)DES(0.069)LCSGR;T(0.007)LS(0.504)DES(0.489)LCSGR 160.86 0.00060471 225339000.0 3122.4 4143.6 4598.7 4628.6 3913.7999999999997 3180.3 3841.1 3590.2 1974.06 2701.88 True False 3195.145844867225 3658.4653856926216 3974.221798850933 3820.3018995828024 3559.7974810375113 3148.3090694813623 3551.3627345126492 3494.9762333868553 3349.8356403621187 3048.6926165398895 1.0480380434330414 1.2000112329608332 1.3035823215793634 1.2530951394892182 1.1676472274458747 1.032675138320285 1.1648805508451898 1.146385245408399 1.098777758764021 1.0 11.573974983075118 -6.531633169895223 23.180200381957025 1.102207961316647 1.2086572672537266 0.32385981722354285 0.07617828589995257 105.6984041059237 279865.8715630807 0.025889429183434145 0.02594035664107667 2.9401320080860824e-07 6.531633169895223 0.10644930593707969 TLS(ph)DESLCSGR ddPTM_A459_Selumetinib_30min_R2 1 TLSDESLCSGR 11 0 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.087)LS(0.579)DES(0.334)LCSGR 190.66 1.985e-05 303930000.0 59776.0 49758.0 57897.0 57743.0 66525.0 35066.0 40179.0 48993.0 36377.0 36185.0 True False 56453.88922228735 53574.27860281293 54171.970053487334 49878.30378776902 58167.53475895423 39896.0232025453 42047.40311317811 49135.56151877225 43653.41645830321 35140.2450300792 1.6065308928257098 1.524584662313955 1.5415934068506763 1.419406829550403 1.6552967888859123 1.1353370805580687 1.1965597586808672 1.3982703158931704 1.2422627224408067 1.0 15.100836630726349 -6.764772245834745 24.999998336025044 1.21950745737526 1.54043460121494 0.7206897989310556 0.10987774969111704 51.353400660119725 385201.4307694112 0.03757132148594127 0.03448947103899468 1.7188095346924798e-07 6.764772245834745 0.3209271438396799 TLS(ph)DESLCSGRR ddPTM_A459_Selumetinib_30min_R2 1 TLSDESLCSGRR 12 1 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.088)LS(0.523)DES(0.389)LCSGRR 92.039 0.011405 2162000.0 10616.0 12164.0 12459.0 14015.0 15206.0 8827.9 10125.0 10846.0 9445.9 12164.0 True False 10026.005219215112 13096.939686575357 11657.401504333531 12106.13282277649 13295.686336635215 10043.863093302612 10595.83256230688 10877.560064348037 11335.343940497742 11812.793714132471 0.8487412429136303 1.1087080671616718 0.9868454310166245 1.024832322966334 1.1255327620534554 0.8502529830252125 0.896979395283128 0.9208287495391079 0.9595819765257119 1.0 13.528062580599931 -6.773468447422182 24.999997673880763 0.9187961059551185 1.0224647533531468 0.2547742305715226 0.07934165709629866 287.7374297925346 598000.7161708676 0.026847288556502074 0.023851343935207582 1.6847348225166419e-07 6.773468447422182 0.10366864739802828 TLS(ph)DPPSPLPHGPPNK ddPTM_A459_Selumetinib_30min_R1 2 TLSDPPSPLPHGPPNK 16 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 T(0.2)LS(0.8)DPPSPLPHGPPNK;T(0.431)LS(0.559)DPPS(0.01)PLPHGPPNK 123.1 0.0013935 29476500.0 7496.8 7205.5 7694.099999999999 8479.8 10215.7 7072.5 7687.5 6474.5 2034.1 4820.0 True False 7671.460853766537 6361.876710253926 6649.28348066605 6998.962115560262 9291.69173872833 7001.357071316209 7107.625685758242 6302.775227860057 3451.719135214019 5438.693950775855 1.4105336544396228 1.169743465588163 1.2225882796213416 1.2868828764600417 1.7084417367156368 1.2873232314014347 1.306862594234468 1.1588766135592052 0.634659564677585 1.0 12.409044528608193 -8.045604980079199 3.820369170860879 0.8215063909517966 1.3374429268372912 0.6217609556431357 0.16139818070554401 0.1537552159815008 4.54369913402813 0.12004567938436338 0.043764024398739276 9.003161070251992e-09 8.045604980079199 0.5159365358854946 TLS(ph)DPPSPLPHGPPNK ddPTM_A459_Selumetinib_30min_R2 1 TLSDPPSPLPHGPPNK 16 0 H0YBF7;A0A0A0MRE5;Q9ULH1;Q9ULH1-2 H0YBF7 ASAP1 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 1 T(0.136)LS(0.559)DPPS(0.305)PLPHGPPNK 102.03 0.0034134 24873000.0 102190.0 99496.0 149560.0 208660.0 203440.0 131780.0 112280.0 139610.0 113910.0 134040.0 True False 96510.68889898191 107127.02326993583 139937.47242861593 180240.1480414229 177882.04842332428 149931.49882026503 117501.24247859906 140016.2419863203 136695.1829113263 130169.91692225526 0.7414208380929019 0.8229783486296459 1.075036965047726 1.384652862220634 1.3665373123773703 1.1518137398045087 0.9026758659512502 1.075642093786891 1.050128832708469 1.0 16.990036545660963 -5.261059942505916 3.585702786395765 1.1426202928592546 0.7650165112600452 0.48785439220285387 0.14210536700372767 0.20579512941159459 5.790247361566222 0.04270554918915728 0.1162489521019021 5.482012954647073e-06 5.261059942505916 -0.3776037815992094 TLS(ph)FDTSK ddPTM_A459_Selumetinib_30min_R1 2 TLSFDTSK 8 0 Q7L804;Q7L804-2 Q7L804 RAB11FIP2 Rab11 family-interacting protein 2 1 T(0.029)LS(0.968)FDT(0.003)SK;T(0.117)LS(0.875)FDT(0.009)SK 150.81 0.0012315 47868000.0 13324.7 11835.9 15357.2 13300.4 12159.599999999999 13552.0 11490.3 13533.1 7581.8 10786.3 True False 13635.139584647177 10450.147325639371 13271.776591061298 10977.734819429428 11059.766326951742 13415.67918423149 10623.577420106401 13174.158226295935 12865.76084723742 12170.82667245925 1.12031334859952 0.858622639765833 1.0904581051255402 0.9019711737634379 0.9087111849171535 1.1022816728291065 0.8728722958602277 1.0824374203033449 1.0570983544076509 1.0 13.57113954232197 TLS(ph)FDTSK ddPTM_A459_Selumetinib_30min_R2 2 TLSFDTSK 8 0 Q7L804;Q7L804-2 Q7L804 RAB11FIP2 Rab11 family-interacting protein 2 1 TLS(0.991)FDT(0.005)S(0.003)K;T(0.022)LS(0.977)FDT(0.001)SK 88.681 0.030729000000000006 51340000.0 172610.0 126436.0 140787.0 200559.0 155173.0 114318.0 185080.0 141301.0 120630.0 135452.0 True False 163017.0272125772 136133.23464418278 131728.91769729563 173242.5182164278 135678.78047577897 130064.26682451878 193686.58672906272 141712.1625163601 144759.37068381452 131541.14881343863 1.2392854151196444 1.0349098808408386 1.0014274535805014 1.3170214779113198 1.0314550366912838 0.9887724715631421 1.4724410458339796 1.0773219163331678 1.100487353118095 1.0 17.005154649640957 TLS(ph)GSGSGSGSSYSGSSSR ddPTM_A459_Selumetinib_30min_R2 1 TLSGSGSGSGSSYSGSSSR 19 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 TLS(0.981)GS(0.018)GSGSGSSYSGSSSR 164.82 1.7227e-07 5029800.0 7225.6 8504.7 9463.7 8965.4 10486.0 10095.0 7265.3 7681.5 5048.9 8894.4 True False 6824.030078368574 9156.983143079367 8854.815845297473 7744.297053822352 9168.6549339706 11485.494616714052 7603.150845918839 7703.851893259215 6058.821078052807 8637.595561573486 0.7900381569990365 1.06013103737069 1.0251482350818029 0.8965801881573158 1.0614823151433097 1.3297097015991535 0.880239273964547 0.891897732226748 0.701447646496323 1.0 13.076414051430193 -7.491579694891226 24.91338112914094 0.8552171297343465 1.0309399873695557 0.22070278390711073 0.14598653545452064 926.2332958068963 737264.1473920625 0.062053744168366606 0.04178417782482203 3.2241876128382235e-08 7.491579694891226 0.17572285763520923 TLS(ph)INEEEPEGGFSK ddPTM_A459_Selumetinib_30min_R1 2 TLSINEEEPEGGFSK 15 0 H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 H0YDJ2 PPFIBP2 Liprin-beta-2 1 TLS(1)INEEEPEGGFSK;T(0.018)LS(0.982)INEEEPEGGFSK 202.16 1.3545e-05 16958600.0 3449.3 3371.6 4168.6 4753.0 3701.2999999999997 3410.8 4073.2 3615.5 2786.92 2893.3 True False 3529.6619788305566 2976.8515045856857 3602.527016480748 3922.977774860013 3366.518068517592 3376.490448758615 3765.955244647867 3519.605195200872 4729.199691416672 3264.683238128586 1.0811652222816768 0.9118347133402461 1.1034843976305109 1.2016411666048132 1.0311928671056556 1.0342474912494484 1.1535438417623098 1.078084744668342 1.4485937368084725 1.0 11.672727303095202 -8.062605966399651 24.99978772682897 1.2373113859181077 1.0737620574172433 0.18767640819587783 0.12418025265894779 327.53223425613874 130787.61177375341 0.0795322629024325 0.0300604145696896 8.65753056739467e-09 8.062605966399651 -0.16354932850086445 TLS(ph)INEEEPEGGFSK ddPTM_A459_Selumetinib_30min_R2 2 TLSINEEEPEGGFSK 15 0 H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 H0YDJ2 PPFIBP2 Liprin-beta-2 1 T(0.036)LS(0.964)INEEEPEGGFSK;T(0.002)LS(0.998)INEEEPEGGFSK 195.17 3.33e-05 14220800.0 54683.0 54438.0 63188.0 60126.0 59522.0 39480.0 53925.0 55931.0 46937.0 67955.0 True False 51643.93777339298 58613.21955424114 59122.55287389252 51936.735076864716 52044.31422656857 44918.01163624272 56432.61935036036 56093.74995012446 56325.71152935588 65992.96258170604 0.7825673488965206 0.8881737879500708 0.8958917824107797 0.7870041447610678 0.7886343056978595 0.6806485097654106 0.8551308676359392 0.8499959352586218 0.8535108794308012 1.0 16.01002456478117 -8.864885832397269 1.1136963605403283 0.9994602779365916 0.8127853068709118 0.47399326570009037 0.058768880261177825 1.145768229533845 2.4020660453827296 0.06143796013402563 0.019155803447635074 1.3649419062048437e-09 8.864885832397269 -0.18667497106567987 TLS(ph)MIEEEIR ddPTM_A459_Selumetinib_30min_R1 3 TLSMIEEEIR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 T(0.004)LS(0.996)MIEEEIR;T(0.05)LS(0.95)MIEEEIR;T(0.006)LS(0.994)MIEEEIR 122.18 0.017245 10976200.0 6295.9 6125.799999999999 6972.6 7018.799999999999 6746.700000000001 5738.8 6553.8 5493.2 3372.3999999999996 4905.2 True False 6442.58222031116 5408.588488192841 6025.759217750237 5793.098339193655 6136.462176226627 5681.072882413493 6059.441589505346 5347.502491571686 5722.716489649355 5534.8302006941285 1.1640072028773691 0.977191402821092 1.0886981170613945 1.0466623417764718 1.1086992651476548 1.0264222526105722 1.0947836464333496 0.9661547504928065 1.0339461703688153 1.0 12.434323342884072 -7.757813230816663 24.998944422232796 1.000037843780162 1.0679640803670016 0.30473966383935314 0.04974921262417479 111.83138239464715 770990.4603294876 0.022512369691089835 0.012347390109221305 1.7465731085830867e-08 7.757813230816663 0.0679262365868396 TLS(ph)MIEEEIR ddPTM_A459_Selumetinib_30min_R2 4 TLSMIEEEIR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 T(0.13)LS(0.87)MIEEEIR;T(0.001)LS(0.999)MIEEEIR;T(0.348)LS(0.652)MIEEEIR;T(0.001)LS(0.999)MIEEEIR 163.45 0.00039198 30471100.0 19904.8 24685.6 27102.6 24854.5 27685.0 19560.4 19371.699999999997 20815.2 23242.3 27463.9 True False 18798.57090122768 26578.90614328549 25358.848223079687 21469.274223596014 24206.962792959763 22254.667548367863 20272.522434295337 20875.76878585815 27891.409444121855 26670.94584721824 0.7048333047096773 0.996549064871565 0.9508042335035747 0.8049686106589745 0.907615460345008 0.834416134915178 0.7600976189755094 0.782715727647712 1.0457600418033508 1.0 14.702981368476333 -8.270491077192757 24.727101691677074 1.022880057262808 0.8493483859388741 0.41770313184112495 0.0847856925944052 646.8818179040135 1767104.2185350193 0.07927628317473775 0.021692688453749595 5.364248924570164e-09 8.270491077192757 -0.173531671323934 TLS(ph)PEFNER ddPTM_A459_Selumetinib_30min_R1 1 TLSPEFNER 9 0 Q9BSJ8;Q9BSJ8-2 Q9BSJ8 ESYT1 Extended synaptotagmin-1 1 T(0.07)LS(0.93)PEFNER 133.89 0.0030136 3641300.0 1912.7 1913.4 1846.5 1495.0 2195.1 1811.6 1992.1 2243.7 1073.2 1875.1 True False 1957.2621885336744 1689.3782384844721 1595.7554420984738 1233.92631462565 1996.5535925763809 1793.3769488011937 1841.8342931510886 2184.1897874352653 1821.1420165732673 2115.787350020706 0.9250750972277624 0.7984631529571907 0.7542135281614464 0.5831995897950587 0.9436456799672432 0.8476168215977107 0.870519569527185 1.0323295426706705 0.8607396279949612 1.0 11.046978919445229 -6.931039073390865 1.3352356209967362 0.9494384317382845 0.7772970951058225 0.3276508381413872 0.10121368884654076 0.5208600409986366 1.9145398934373854 0.05385056421895342 0.04176070906130939 1.172089908100993e-07 6.931039073390865 -0.172141336632462 TLS(ph)PGRR ddPTM_A459_Selumetinib_30min_R2 1 TLSPGRR 7 1 Q13523 Q13523 PRPF4B Serine/threonine-protein kinase PRP4 homolog 1 T(0.019)LS(0.981)PGRR 82.287 0.021275 113560000.0 14055.0 10727.0 10460.0 13925.0 13415.0 9973.7 14533.0 15656.0 12685.0 18216.0 True False 13273.879366622883 11549.726407258619 9787.014987986899 12028.390978035151 11729.687768378364 11347.486642765813 15208.813296593182 15701.556368009673 15222.354448513526 17690.05674914806 0.7503582128000885 0.6528936888693048 0.5532494964131889 0.6799520854343459 0.6630667122615792 0.641461291146638 0.8597379597058458 0.8875921988642488 0.8605034265504333 1.0 14.110651055705755 -7.328681521442345 3.7353066633327576 0.9007073971784911 0.6523969077277123 0.8170171418891553 0.05704402982676078 0.10254894707642584 2.830228873365281 0.025492565570745886 0.016849900219961918 4.691573003265191e-08 7.328681521442345 -0.24831048945077883 TLS(ph)PTPASATAPTSQGIPTS(ph)DEESTPKK ddPTM_A459_Selumetinib_30min_R2 1 TLSPTPASATAPTSQGIPTSDEESTPKK 28 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 2 T(0.333)LS(0.491)PT(0.176)PASATAPTSQGIPT(0.302)S(0.693)DEES(0.002)T(0.002)PKK 117.83 1.0106e-11 7596900.0 35958.0 42420.0 38642.0 41883.0 32342.0 28144.0 32598.0 36436.0 25131.0 35952.0 True False 33959.59831127891 45673.477598201775 36155.81579022847 36178.46314779506 28278.908818851505 32020.58053420506 34113.871591711584 36542.022727695505 30157.9022188091 34913.97234548592 0.9726649828108029 1.3081719016744013 1.0355686666774573 1.036217328403556 0.8099596499367603 0.9171279686353148 0.9770836516149736 1.0466303394554897 0.8637774562111166 1.0 15.091516888749041 -5.743320065001423 2.5126842673216454 0.9404695282128762 1.140914117880749 0.35622887570647144 0.10225699037340319 0.2745140629327686 3.5307657058637942 0.029110544221496084 0.05399145397527307 1.8058427710730318e-06 5.743320065001423 0.2004445896678727 TLS(ph)PTPASATAPTSQGIPTSDEESTPKK ddPTM_A459_Selumetinib_30min_R2 1 TLSPTPASATAPTSQGIPTSDEESTPKK 28 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.14)LS(0.823)PT(0.037)PASATAPTSQGIPTSDEESTPKK 158.15 1.6563999999999998e-20 0.0 9463.5 9759.1 10619.0 11824.0 10261.0 7946.5 10016.0 8001.9 6409.5 10504.0 True False 8937.556555392073 10507.591589547648 9935.785101093003 10213.550802462303 8971.921445496115 9041.05824385519 10481.76384632748 8025.184204214146 7691.579096393176 10200.722227330434 0.8761689962938108 1.030083101507757 0.9740276109540955 1.0012576143969 0.87953786462864 0.8863155022133435 1.0275511490984492 0.7867270596500073 0.7540229921941606 1.0 13.31638368046202 -7.770705732375774 24.995883369540913 0.8277812544171128 0.9536941261784763 0.2543443692912578 0.08173132986360378 233.6630698189049 630292.6284730887 0.0426158232053259 0.020915567405996136 1.695486232522946e-08 7.770705732375774 0.12591287176136345 TLS(ph)PTPSAEGYQDVR ddPTM_A459_Selumetinib_30min_R1 5 TLSPTPSAEGYQDVR 15 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 T(0.16)LS(0.839)PTPSAEGYQDVR;T(0.127)LS(0.834)PT(0.037)PS(0.001)AEGYQDVR;T(0.132)LS(0.868)PTPSAEGYQDVR;T(0.152)LS(0.846)PT(0.002)PSAEGYQDVR;T(0.155)LS(0.838)PT(0.008)PSAEGYQDVR 260.29 2.2043e-36 286272300.0 5739.38 6576.9400000000005 7762.530000000001 7302.25 7187.439999999999 5314.9800000000005 6828.4400000000005 6438.0199999999995 3276.63 5421.5599999999995 True False 5873.096387110576 5806.9088072635495 6708.421062525134 6027.049117709138 6537.3373210455975 5261.516126815725 6313.36527319142 6267.262795963803 5560.201794413404 6117.470036466461 0.9600531514009607 0.9492337146971469 1.0966005591422585 0.9852192298093295 1.0686341383082045 0.8600804083144888 1.0320222633796683 1.0244860634550592 0.9089054398744643 1.0 12.578719414624764 TLS(ph)PTPSAEGYQDVR ddPTM_A459_Selumetinib_30min_R2 2 TLSPTPSAEGYQDVR 15 0 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;J3QSX6;O14639-4;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 TLS(0.723)PT(0.236)PS(0.04)AEGYQDVR;T(0.02)LS(0.98)PTPSAEGYQDVR 209.53 1.3801e-06 28226100.0 42894.0 37681.0 39921.0 40700.0 43025.0 30336.0 38457.0 34381.0 31081.0 38918.0 True False 40510.12319828683 40571.01153648847 37352.52632269836 35156.589788583864 37619.81485161976 34514.508637210216 40245.326701099846 34481.04301791903 37298.06847569953 37794.33621889242 1.071856983111582 1.073468027101057 0.9883101559547112 0.9302078910704611 0.9953823407226445 0.9132190716967082 1.0648507349887584 0.9123336051787262 0.9868692562737795 1.0 15.205882430896889 -5.308586116978542 4.154849665243408 0.9700008960294962 1.0741349208269995 0.452688809441242 0.04363030072939153 0.16599905763491427 6.186095947122563 0.01081081428119094 0.02557312881900445 4.913759347830602e-06 5.308586116978542 0.10413402479750322 TLS(ph)SSAQEDIIR ddPTM_A459_Selumetinib_30min_R2 3 TLSSSAQEDIIR 12 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 1 T(0.185)LS(0.385)S(0.385)S(0.044)AQEDIIR;T(0.109)LS(0.297)S(0.297)S(0.297)AQEDIIR;T(0.189)LS(0.404)S(0.404)S(0.003)AQEDIIR 220.99 2.8549000000000006e-08 155358000.0 204614.0 168094.0 196886.0 202267.0 224230.0 102623.5 169609.0 198402.0 124553.0 154381.0 True False 193242.37301474024 180986.26929260063 184218.56911326892 174717.88566996309 196060.22275836635 116758.95560161995 177496.15457385746 198979.31697278054 149467.08030159277 149923.61939999048 1.2889388195676958 1.207189834509906 1.228749478237854 1.1653793202778973 1.307734055134336 0.7787896001237238 1.1839105491463924 1.3272045977085927 0.9969548554108764 1.0 17.193868161971487 TLS(ph)SSSMDLSRR ddPTM_A459_Selumetinib_30min_R1 1 TLSSSSMDLSRR 12 1 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 T(0.002)LS(0.54)S(0.332)S(0.076)S(0.049)MDLS(0.001)RR 64.798 0.041193 4420700.0 1168.1 1589.6 1939.6 1840.0 2166.5 1709.8 1961.9 1710.3 936.15 1158.9 True False 1195.3144572730607 1403.4888930150091 1676.212973460168 1518.6785410777247 1970.5404575266423 1692.6009643741884 1813.912303465249 1664.937288162648 1588.5781763092302 1307.6561036419373 0.9140893037121953 1.0732859267097588 1.2818454093486564 1.1613745669431523 1.5069255991988366 1.2943777493640307 1.3871478123440433 1.2732225877473833 1.214828709081004 1.0 10.352767465556594 -4.9469394258132455 1.5159623907850839 1.2919064317381563 0.8297578488801779 0.4320603117265478 0.1280177192477399 0.6832740087781102 1.8748686475929501 0.035391650401328925 0.4341309747852194 1.1299535064554886e-05 4.9469394258132455 -0.46214858285797844 TLS(ph)TSDDVEDR ddPTM_A459_Selumetinib_30min_R2 2 TLSTSDDVEDR 11 0 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 T(0.001)LS(0.967)T(0.03)S(0.003)DDVEDR;TLS(0.974)T(0.013)S(0.013)DDVEDR 140.78 0.001058 10716300.0 44847.0 35355.0 44663.0 63017.0 59817.0 30436.0 58399.0 65305.0 57398.0 54289.0 True False 42354.5832767653 38066.614815757275 41789.4312053976 54433.97588961157 52302.253689235105 34628.282729500635 61114.66921542317 65495.02673817522 68879.20383411749 52721.53551023817 0.8033639928514661 0.7220316033542875 0.7926444251094009 1.0324808517582127 0.9920472380604005 0.6568147606925457 1.1591974441555313 1.2422822306732042 1.3064718841647092 1.0 15.686104768877692 -7.3780313337180745 6.461654724238103 1.2039039850620346 0.843299107319603 0.6295645086437209 0.1287123819120286 0.16274144591215678 8.07673735944575 0.05657227742970099 0.037828064105574655 4.187633508585175e-08 7.3780313337180745 -0.36060487774243155 TLS(ph)TSDDVEDRENEK ddPTM_A459_Selumetinib_30min_R2 1 TLSTSDDVEDRENEK 15 1 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 T(0.002)LS(0.993)T(0.004)S(0.001)DDVEDRENEK 134.02 0.0023114 6556100.0 24700.0 17996.0 21701.0 30369.0 26840.0 11380.0 23075.0 30550.0 21040.0 34160.0 True False 23327.2728819342 19376.235333739725 20304.781286262292 26232.68981055293 23468.11924735561 12947.491702645446 24148.033222245074 30638.89544217523 25248.58790671851 33173.71204166104 0.7031854877331413 0.5840840274192461 0.612074441978716 0.7907673937004317 0.7074312099255968 0.3902937267431936 0.7279267750295441 0.923589600214095 0.7611022810775652 1.0 15.017752834076985 -7.583688449791404 5.392133590963112 0.8769415959849628 0.6328522848507244 0.5173202507592294 0.11328434466952167 0.17561098374532438 10.211570987678124 0.05539906937079848 0.031537962561327036 2.6080237993790764e-08 7.583688449791404 -0.24408931113423837 TLSAS(ph)AAEVAPR ddPTM_A459_Selumetinib_30min_R2 2 TLSASAAEVAPR 12 0 Q16825 Q16825 PTPN21 Tyrosine-protein phosphatase non-receptor type 21 1 TLSAS(0.999)AAEVAPR;TLS(0.001)AS(0.999)AAEVAPR 143.76 0.00079925 9374600.0 27001.0 31579.0 29800.0 30333.0 34945.0 35172.0 28288.0 27244.0 24016.0 31395.0 True False 25500.392513567003 34001.00775751095 27882.70044378675 26201.59307265638 30554.896687736255 40016.62374037313 29603.448051608608 27323.27552951301 28819.8710631061 30488.54477599383 0.8363925763241277 1.1152059898996156 0.91453038013612 0.8593913965118819 1.0021762898895283 1.3125134057523646 0.9709695319705081 0.8961816882459703 0.9452688304690221 1.0 14.895979671433361 -4.729470909413894 23.707855522811485 1.0001398306094509 0.8363905113756281 0.13880261692205897 0.12354342587607445 5063.0029143232205 3754323.313031985 0.032803044463907666 4.2745493361207005 1.8643570553239725e-05 4.729470909413894 -0.16374931923382274 TLSDES(ph)IYNSQR ddPTM_A459_Selumetinib_30min_R2 1 TLSDESIYNSQR 12 0 O43166-3;O43166-2;O43166;F5GYF8 O43166-3 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 1 T(0.115)LS(0.346)DES(0.539)IYNSQR 122.52 0.0035218000000000007 36140000.0 7125.8 5639.1 5495.0 5467.2 8640.2 4295.3 5488.4 4527.3 6879.5 8846.4 True False 6729.776562837513 6071.600837435634 5141.457682503633 4722.55792855395 7554.740831631962 4886.938586148772 5743.621475058281 4540.473693465136 8255.592229290403 8590.981446292455 0.7833536371728321 0.7067412350257035 0.5984715151168779 0.5497111078725503 0.8793804152484003 0.5688452031586905 0.6685640646490992 0.5285162960542342 0.9609603141272302 1.0 13.06860724103364 -8.328394124529451 7.442106595474553 0.9867417360808645 0.6609360862494777 0.60318531323635 0.10384944727254608 0.211563778521737 20.459762937417505 0.09780584009606046 0.02543400884791714 4.694678706628957e-09 8.328394124529451 -0.3258056498313867 TLSDES(ph)LCSGR ddPTM_A459_Selumetinib_30min_R1 1 TLSDESLCSGR 11 0 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 T(0.006)LS(0.148)DES(0.846)LCSGR 163.45 0.00063837 23978000.0 1735.6 1601.6 1714.3 2013.0 1566.4 1547.1 1867.2 1464.0 814.28 1284.2 True False 1776.0361031102873 1414.08392743636 1481.5074759758527 1661.4673386899226 1424.719396570382 1531.5375786544075 1726.355600708655 1425.1699642578005 1381.7736873418576 1449.0395791672934 1.2256643149325888 0.9758766756729854 1.022406494118827 1.1465990043175378 0.9832163434687635 1.0569328820780193 1.1913791904157127 0.9835272857604002 0.9535789823877061 1.0 10.500881285967242 -1.522878855222237 0.10670591642055989 0.9589537304734077 1.389874385427239 0.14959786376081685 0.08601615820614252 286.90595267346566 2.156262779121988 0.9070055986732729 18.15688530279274 0.0299999924054836 1.522878855222237 0.43092065495383136 TLSDES(ph)LCSGRR ddPTM_A459_Selumetinib_30min_R1 1 TLSDESLCSGRR 12 1 O60292;M0R2Q7 O60292 SIPA1L3 Signal-induced proliferation-associated 1-like protein 3 1 TLS(0.094)DES(0.813)LCS(0.094)GRR 127.17 0.0047236000000000005 16229000.0 3222.0 2503.7 7265.9 6467.6 4707.4 3174.2 2974.0 3394.3 2242.2 2442.4 True False 3297.066331079363 2210.565640061449 6279.23068873182 5338.155071888204 4281.616501158969 3142.2704299430034 2749.668785618864 3304.272137759735 3804.8496361913753 2755.905830990652 1.196363930147128 0.8021194393521159 2.27846344317021 1.936987473178401 1.5536149504861267 1.1401951382400708 0.9977368437986338 1.1989786082683256 1.3806167080910978 1.0 11.428310876810286 -6.753700749207858 7.705073348744907 1.1462408090791203 1.5742064391901107 0.22173327032248347 0.3831369654378714 0.22953218283943258 87.16545905118367 0.14264015842137323 0.13602243450559465 1.763190555115008e-07 6.753700749207858 0.4279656301109904 TLSDFNSLISS(ph)PHLGR ddPTM_A459_Selumetinib_30min_R1 1 TLSDFNSLISSPHLGR 16 0 Q9NRJ4 Q9NRJ4 TULP4 Tubby-related protein 4 1 TLSDFNSLIS(0.366)S(0.634)PHLGR 165.49 1.1929e-05 7469600.0 2127.8 2731.2 2814.2 3063.2 2932.8 2249.8 2184.3 2087.6 1062.9 2003.4 True False 2177.373600021934 2411.4298342995676 2432.0470972940843 2528.2696233854795 2667.528757827894 2227.1690546549603 2019.536492409981 2032.230066519524 1803.663668855504 2260.5559047685356 0.9632027216972904 1.0667419590078575 1.0758623983436093 1.1184282671586288 1.1800322001331038 0.9852306903610978 0.8933804681184236 0.8989957126176932 0.7978850091921023 1.0 11.142461881387778 -7.038978682477574 3.9671794326213545 0.891546713445319 1.0825476541721983 0.6135865236030587 0.06826461611971087 0.1498523880180923 5.037370837071943 0.027113712227910685 0.021582020414581623 9.141581121941465e-08 7.038978682477574 0.19100094072687934 TLSDVEDQKELAS(ph)PVSPELR ddPTM_A459_Selumetinib_30min_R1 2 TLSDVEDQKELASPVSPELR 20 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 TLS(0.001)DVEDQKELAS(0.992)PVS(0.007)PELR;T(0.001)LS(0.005)DVEDQKELAS(0.976)PVS(0.017)PELR 63.894 0.010379 48135000.0 4219.6 4832.200000000001 5851.8 6178.1 4843.5 4980.3 4086.2 4604.200000000001 2725.2200000000003 3864.6 True False 4317.908470087673 4266.4437775711685 5057.157701636526 5099.210812300157 4405.406280189376 4930.2027037505995 3777.974644181506 4482.081659450659 4624.499297806375 4360.659054391777 0.9901963020335083 0.97839425746305 1.1597232525077328 1.169367003633214 1.0102615740509526 1.1306095345347429 0.866376985005643 1.0278450123122083 1.06050467145531 1.0 12.090330479904592 -7.221251091095058 24.99990581106542 0.9910018114593275 1.0742455296594098 0.21677566026886874 0.07853504603358978 881.4099741102384 548298.9686640791 0.03142677069482251 0.024342701387061044 6.00826264166389e-08 7.221251091095058 0.08324371820008225 TLSDVEDQKELAS(ph)PVSPELR ddPTM_A459_Selumetinib_30min_R2 1 TLSDVEDQKELASPVSPELR 20 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 TLSDVEDQKELAS(0.989)PVS(0.011)PELR 67.097 0.0081936 4290200.0 20035.0 17449.0 20979.0 18670.0 20812.0 13050.0 13084.0 13204.0 11162.0 20351.0 True False 18921.534906459576 18787.282192621955 19629.233980208144 16127.113792453583 18197.410498359342 14847.519043894823 13692.43192545415 13242.421453960127 13394.711892338022 19763.413751751876 0.9574021545130241 0.9506091623951659 0.9932106986561551 0.8160085092092978 0.920762512333998 0.7512628754523092 0.6928171467462406 0.6700472712001128 0.677752945953008 1.0 14.270544545973495 -6.531588426373317 1.3286009582575562 0.7295463865169962 0.952211356349048 0.39435997032606274 0.10052270309014871 0.3722685563393843 1.3620088653681846 0.04161297588013093 0.046167169179461426 2.940434933044235e-07 6.531588426373317 0.22266496983205175 TLSDVEDQKELASPVS(ph)PELR ddPTM_A459_Selumetinib_30min_R2 1 TLSDVEDQKELASPVSPELR 20 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 TLSDVEDQKELAS(0.261)PVS(0.739)PELR 70.391 0.006053800000000001 4272200.0 19696.0 14946.0 18795.0 17705.0 18893.0 14820.0 12955.0 13953.0 11061.0 16131.0 True False 18601.375169335057 16092.310141035448 17585.75016244874 15293.548457171435 16519.492434437 16861.320477434583 13557.433169845504 13993.600919956509 13273.509070162241 15665.256116628641 1.1874287295941321 1.0272612219824155 1.1225957642519167 0.9762718428163687 1.0545306320846928 1.0763514079757892 0.8654459951953364 0.8932889967309456 0.8473215484854049 1.0 13.935280736565756 -7.257528761912874 24.861485183666627 0.8926215476471828 1.0688171995103972 0.6291810999679279 0.06467953562022283 194.68354939461506 1237692.491044672 0.024361104785171346 0.018145678241819813 5.5267680474280316e-08 7.257528761912874 0.1761956518632144 TLSGGRPGAGPELELGTAGS(ph)PGGAPPEAAPGDCTR ddPTM_A459_Selumetinib_30min_R2 2 TLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTR 35 1 Q8WYP3;Q8WYP3-2 Q8WYP3 RIN2 Ras and Rab interactor 2 1 TLSGGRPGAGPELELGT(0.04)AGS(0.96)PGGAPPEAAPGDCTR;TLSGGRPGAGPELELGT(0.41)AGS(0.59)PGGAPPEAAPGDCTR 104.5 3.2033999999999996e-14 13803500.0 19904.4 16360.8 18751.3 19970.7 21787.6 17385.6 14825.3 13770.800000000001 12090.5 17690.9 True False 18798.193131626365 17615.620751736435 17544.861772871773 17250.656208620934 19050.446904384673 19780.308589236633 15514.705825774634 13810.87074812134 14508.937836795634 17180.117750521717 1.0941830204310161 1.0253492442565764 1.0212305891989 1.0041058192454517 1.1088659100608411 1.1513488368632372 0.9030616699529601 0.8038868504089234 0.8445191149143919 1.0 14.068452304123124 -7.401653420610492 5.819083290357968 0.8656263217650993 1.0619164570951494 0.6561417443265942 0.0633147831852116 0.13793586913327274 5.998415076393679 0.027463208348084384 0.018260595984122475 3.965944016532099e-08 7.401653420610492 0.19629013533005002 TLSGS(ph)GSGSGSSYSGSSSR ddPTM_A459_Selumetinib_30min_R2 1 TLSGSGSGSGSSYSGSSSR 19 0 E7ERS3;Q86VM9 E7ERS3 ZC3H18 Zinc finger CCCH domain-containing protein 18 1 TLS(0.094)GS(0.845)GS(0.059)GS(0.001)GSS(0.001)YSGSSSR 123.59 0.00041177 5160000.0 8872.8 9565.7 8589.8 9975.2 11345.0 8918.0 6792.8 6656.4 8160.4 8351.8 True False 8379.685296632615 10299.358431426652 8037.141619867104 8616.560551820197 9919.739674413164 10146.373550456248 7108.678659677844 6675.7690219736605 9792.7080206267 8110.661833417588 1.0331691135372696 1.2698542539390787 0.9909353619888865 1.0623745298217468 1.223049348888127 1.25099205944589 0.876460985019574 0.8230856074492127 1.2073870445786232 1.0 12.98560392843033 -7.266891331710259 24.997351751926885 0.9619905445516211 1.1380607954890345 0.27386873964753555 0.12806118761640575 594.7634825996066 2726992.4163925042 0.052661869339338474 0.03662257874485287 5.408896463315955e-08 7.266891331710259 0.17607025093741335 TLSNAEDYLDDEDS(ph)D ddPTM_A459_Selumetinib_30min_R1 1 TLSNAEDYLDDEDSD 15 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 1 TLSNAEDYLDDEDS(1)D 97.797 0.015272 0.0 298.48 371.95 222.3 183.19 389.75 283.0 427.01 324.31 48.76 220.06 True False 305.4340032590218 328.40192108513617 192.11288100649372 151.19930540218925 354.4971813159515 280.15327694344097 394.80029191227663 315.708245292655 82.74215871050369 248.30684456591993 1.230066790115952 1.322564916239966 0.7736914435135196 0.6089212146628894 1.4276577109087316 1.1282543476930478 1.5899694291651552 1.2714439903763568 0.33322544473210236 1.0 7.9559802196552125 -8.244109681033187 24.53602318497949 0.6666126513064888 1.1636256366974502 0.29258716869012835 0.31242182939801844 742.2406864668252 1050896.359576638 0.22227939645218686 0.08354314875012422 5.700202955253807e-09 8.244109681033187 0.4970129853909614 TLSPSSGYSSQSGT(ph)PTLPPK ddPTM_A459_Selumetinib_30min_R2 1 TLSPSSGYSSQSGTPTLPPK 20 0 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 TLSPSSGYSSQS(0.002)GT(0.998)PTLPPK 159.4 2.5715e-06 3541400.0 26133.0 16999.0 23151.0 24669.0 27264.0 13177.0 22564.0 18845.0 16341.0 19850.0 True False 24680.6324786877 18302.768639600003 21661.489864902942 21309.039643601358 23838.852576747493 14992.012141103607 23613.270709717784 18899.835830042295 19609.65660568857 19276.878923506207 1.2803230531573326 0.949467427389484 1.1237031653754355 1.105419592464065 1.2366552008415854 0.7777198892307386 1.2249530021648778 0.9804406566560863 1.017263047794349 1.0 14.234583866486815 TLSPT(ph)PASATAPTSQGIPTSDEESTPKK ddPTM_A459_Selumetinib_30min_R2 1 TLSPTPASATAPTSQGIPTSDEESTPKK 28 1 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.029)LS(0.14)PT(0.828)PAS(0.003)ATAPTSQGIPTSDEESTPKK 114.92 5.3319e-12 5820300.0 21422.0 18672.0 19585.0 22482.0 21767.0 16615.0 17119.0 18073.0 16412.0 18780.0 True False 20231.450999060504 20104.082360057146 18324.922422535696 19419.912816386797 19032.434860551013 18903.56543404694 17915.067420654977 18125.58943785379 19694.858589594318 18237.77260370009 1.1093158928276108 1.1023321102259174 1.0047785341296516 1.0648182340230996 1.0435723305755935 1.036506257908478 0.9823056691155563 0.9938488559823615 1.0798938564240357 1.0 14.15464192211027 -1.522881122906828 0.45405722988032504 1.0163367416396207 3.4406760078328147 0.46812455530349684 0.031949038291452174 77.90395774553558 0.9298622121329841 0.019868860407366788 175.54816091655 0.029999835759830177 1.522881122906828 2.424339266193194 TLSS(ph)PSLQTDGIAATPVPPPPPPK ddPTM_A459_Selumetinib_30min_R2 1 TLSSPSLQTDGIAATPVPPPPPPK 24 0 Q9H7D0 Q9H7D0 DOCK5 Dedicator of cytokinesis protein 5 1 T(0.079)LS(0.337)S(0.447)PS(0.137)LQTDGIAATPVPPPPPPK 169.44 4.6002e-16 8162600.0 80823.0 63896.0 83480.0 105670.0 108550.0 85503.0 70754.0 90770.0 92050.0 110410.0 True False 76331.18122010388 68796.61774197799 78108.98768615177 91277.56370908252 94912.97855068734 97280.26213104508 74044.20119639122 91034.12567221756 110462.5720918934 107222.17642036865 0.7118973310226848 0.6416267607948771 0.7284779165451977 0.851293703937004 0.8851991418135123 0.9072774437039413 0.6905679745400625 0.8490232964057247 1.0302213196906267 1.0 16.710243799102585 -2.7428403186513277 0.14603331503799508 1.0454472075933303 9.062019110066024e-16 0.5690178449134801 0.08252017595980486 41.52371556020593 0.5571277240294715 0.3756393965940956 8.618757277781528 0.0018078387097699151 2.7428403186513277 -1.0454472075933294 TLSS(ph)PSNRPSGETSVPPPPAAPPFLPVGR ddPTM_A459_Selumetinib_30min_R2 2 TLSSPSNRPSGETSVPPPPAAPPFLPVGR 29 1 H3BUF6 H3BUF6 ATXN2L 1 T(0.034)LS(0.097)S(0.286)PS(0.199)NRPS(0.246)GET(0.109)S(0.029)VPPPPAAPPFLPVGR;T(0.034)LS(0.126)S(0.473)PS(0.36)NRPS(0.007)GETSVPPPPAAPPFLPVGR 122.68 3.9929e-12 5764100.0 6263.599999999999 11558.1 9758.6 14731.0 12249.5 7365.7 9251.6 4241.3 5162.59 12572.4 True False 5915.494187177447 12444.569104850927 9130.742300360325 12724.612387607602 10710.608298080573 8380.258315832654 9681.81773169761 4253.641480814986 6195.252254816822 12209.402144981837 0.4845031818047506 1.0192611363829756 0.747845159978872 1.0421978272570471 0.8772426504505562 0.6863774504533793 0.7929804929618864 0.34839064438247425 0.5074165123935344 1.0 13.575704937484348 -7.2894949740261055 1.998145569656721 0.5845793062279414 0.8424730005546811 0.09940245181208285 0.21911238501343336 0.538385659409447 4.195043903400017 0.10903595133982386 0.06784413454235205 5.13458119582086e-08 7.2894949740261055 0.2578936943267397 TLSS(ph)PSNRPSGETSVPPPPAVGR ddPTM_A459_Selumetinib_30min_R1 3 TLSSPSNRPSGETSVPPPPAVGR 23 1 Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 T(0.023)LS(0.106)S(0.521)PS(0.229)NRPS(0.106)GET(0.011)S(0.003)VPPPPAVGR;T(0.006)LS(0.099)S(0.472)PS(0.079)NRPS(0.236)GET(0.079)S(0.027)VPPPPAVGR;T(0.03)LS(0.126)S(0.559)PS(0.273)NRPS(0.01)GET(0.002)S(0.001)VPPPPAVGR 109.5 9.2196e-06 198993000.0 3646.33 4186.45 4465.82 4398.0 3888.7200000000003 3346.78 3960.1099999999997 3939.7 2024.3200000000002 3208.32 True False 3731.2823944769116 3696.2984877721956 3859.3861729933406 3629.9718606846927 3536.985962609277 3313.1144318331076 3661.3957143971493 3835.206358050855 3435.123189516957 3620.1391236832355 1.0307013810785801 1.0210376898475308 1.06608780522962 1.0027161213051539 0.9770303962822965 0.9151898086342737 1.0113964102771658 1.059408555036085 0.9488925900786824 1.0 11.82182942649849 -5.954184893336205 7.062595576325588 0.986393536100291 1.037306052376497 0.29529764119708946 0.03720864754510674 0.29336359953002905 35.57904331391364 0.011141599890916334 0.01653388322195774 1.1112585275340903e-06 5.954184893336205 0.050912516276205966 TLSS(ph)PSNRPSGETSVPPPPAVGR ddPTM_A459_Selumetinib_30min_R2 2 TLSSPSNRPSGETSVPPPPAVGR 23 1 Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 T(0.002)LS(0.112)S(0.431)PS(0.431)NRPS(0.02)GET(0.002)S(0.002)VPPPPAVGR;T(0.018)LS(0.132)S(0.371)PS(0.371)NRPS(0.066)GET(0.029)S(0.013)VPPPPAVGR 83.39299999999999 0.00019827 148629000.0 141484.0 139228.0 135392.0 129805.0 132228.0 120998.0 110479.0 121811.0 85597.0 158778.0 True False 133620.88568532706 149906.3399114203 126681.02612366351 112125.33507388535 115616.33650668181 137664.3761895163 115616.49240998532 122165.44984310343 102718.79178000867 154193.6665852127 0.8665783014601549 0.9721951830529754 0.8215708785526236 0.72717211774662 0.7498124862527235 0.8928017553395312 0.7498134973403184 0.7922857828637898 0.6661673858260758 1.0 17.23438398305062 -5.430622772495908 5.606043739245025 0.787280679478699 0.917490227058035 0.21388201353427883 0.09119399749269469 0.289485052682963 13.82627880844758 0.022688517639691246 0.047948639366297854 3.7100283434763625e-06 5.430622772495908 0.130209547579336 TLSS(ph)PTEPVKR ddPTM_A459_Selumetinib_30min_R1 1 TLSSPTEPVKR 11 1 J3QQN1;P40306 J3QQN1 PSMB10 Proteasome subunit beta type-10 1 TLS(0.037)S(0.929)PT(0.034)EPVKR 131.12 0.0040662 4162000.0 3936.8 4970.4 5135.1 5842.1 4805.3 4191.6 4654.8 4284.1 2434.5 3888.3 True False 4028.5197803206806 4388.463257323731 4437.781625085228 4821.886904799007 4370.66146344462 4149.436309668294 4303.684688399018 4170.471751281995 4131.168691155071 4387.401180249329 0.9182018271900421 1.0002420743011111 1.0114829811011348 1.0990303158292416 0.9961845939960845 0.9457617708514379 0.9809188883325338 0.9505562814852947 0.9415981172982918 1.0 12.099150915863952 -6.591563532296172 6.634413517031666 0.9622877856587598 1.0119012996203567 0.18158027904801533 0.04373515891877246 0.3467037485680503 26.566555675134516 0.015166452313130761 0.015177457595771673 2.5611585685901984e-07 6.591563532296172 0.049613513961596856 TLSS(ph)SSMDLSR ddPTM_A459_Selumetinib_30min_R1 2 TLSSSSMDLSR 11 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 TLS(0.001)S(0.97)S(0.027)S(0.001)MDLSR;TLS(0.001)S(0.694)S(0.293)S(0.012)MDLSR 245.13 3.2363e-11 172333000.0 9048.6 10612.2 9307.3 9923.9 9373.5 8932.6 9617.3 9002.0 5771.0 7185.200000000001 True False 9259.414774489363 9369.718690522068 8043.419781339354 8190.877159674581 8525.668580025835 8842.74615415188 8891.859318067345 8763.237717383001 9792.965502836683 8107.490409774827 1.1420814958135153 1.1556866819386467 0.9920973537806193 1.0102851493723901 1.0515792371147095 1.0906884507061014 1.0967462024187955 1.0808816630627858 1.207891099202505 1.0 12.985039696802499 -6.952392215399408 5.051759724325232 1.1020471902869293 1.0674482056170362 0.030320651670485477 0.06682410298314531 0.7083093718014941 40.429126897810534 0.025320158318519234 0.02193189301370645 1.1158550534823757e-07 6.952392215399408 -0.034598984669893085 TLSS(ph)SSMDLSR ddPTM_A459_Selumetinib_30min_R2 2 TLSSSSMDLSR 11 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 T(0.005)LS(0.026)S(0.522)S(0.096)S(0.351)MDLSR;TLS(0.001)S(0.904)S(0.091)S(0.004)MDLSR 232.17 2.1814e-07 42825600.0 148070.0 113962.0 143812.0 145248.0 153660.0 143361.0 96825.0 124192.0 113744.0 139302.0 True False 139840.86217117382 122702.51895441454 134559.2924906666 125464.97183322455 134355.85706217078 163107.67644841442 101327.55435509772 124553.37815890768 136495.97827289853 135279.98930993758 1.0337143200890333 0.9070263797352393 0.9946725541379234 0.9274466421325182 0.9931687439326334 1.2057043859954877 0.74902101095638 0.9207080721565232 1.0089886831686172 1.0 17.045588925293053 -7.2793125111238695 24.998730585750543 0.9130718209850315 1.0003415439169852 0.15772468576479193 0.1005585265416254 1734.1829707792056 2425551.4361150023 0.04241289814860102 0.028651202993880562 5.256388892219554e-08 7.2793125111238695 0.08726972293195367 TLSSFFT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TLSSFFTPR 9 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 TLSSFFT(1)PR 158.47 0.0020454 51168000.0 5594.5 6296.0 7467.6 7281.9 6193.6 4826.8 6218.4 5325.4 3523.0 4516.1 True False 5724.840964997979 5558.861393069011 6453.540936590608 6010.252863192328 5633.389973568897 4778.24677438375 5749.341081537437 5184.153092662904 5978.27369026055 5095.785425539175 1.1234462378078343 1.0908743066788058 1.2664467589719541 1.1794556405515044 1.1054998401885887 0.9376860239122359 1.128254155428672 1.017341324201142 1.1731800284012157 1.0 12.315088814213116 -6.520938309858072 24.958527345345704 1.0532314413097195 1.1639340972147363 0.3423909014211488 0.07430697503681244 88.13857343796425 1133691.1952535023 0.024144865734276353 0.02450831995632736 3.013434042452412e-07 6.520938309858072 0.11070265590501682 TLSSFFT(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 TLSSFFTPR 9 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 TLSSFFT(1)PR;TLSSFFT(1)PR;TLSSFFT(1)PR 131.09 0.0086235 49242800.0 188290.0 189040.0 189227.0 210429.0 208720.0 161548.0 176751.0 170701.0 151990.0 180092.0 True False 177825.59558459048 203538.76014059538 177052.34083477972 181768.20718972804 182498.72761952545 183799.7706132661 184970.27172546228 171197.71164892812 182392.246955425 174892.27602479034 1.0167721504143747 1.163795021523675 1.0123508302315376 1.0393152363341824 1.0434922099913488 1.0509313206445616 1.057624018222757 0.978875199866811 1.0428833742753258 1.0 17.41610704964952 -6.1407448393208695 0.26503222015862765 0.9973779317486156 1.1052234756644321 0.16938517865202474 0.043146816357831554 7.093741315472816 0.7770121511698951 0.06516656797234908 0.24605167659693705 7.231945767204603e-07 6.1407448393208695 0.10784554391581658 TLSSPS(ph)NRPSGETSVPPPPAVGR ddPTM_A459_Selumetinib_30min_R1 1 TLSSPSNRPSGETSVPPPPAVGR 23 1 Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 TLS(0.008)S(0.047)PS(0.757)NRPS(0.11)GET(0.058)S(0.02)VPPPPAVGR 79.383 0.00035113 21099000.0 581.34 705.48 759.2 754.64 574.45 465.93 596.61 542.72 249.88 388.92 True False 594.8840909092729 622.8820736312463 656.1048099870897 622.856290347225 522.4910989273852 461.24316723059184 551.6072273665335 528.3253025969904 424.02810948688807 438.84167040160685 1.3555779476567562 1.4193776836671286 1.4950832025287253 1.4193189306230123 1.1906141421101293 1.0510468771310715 1.2569618260310809 1.2039086947087143 0.9662439510332688 1.0 8.777556713755141 -6.33235996708898 3.5284330000639277 1.118760258276838 1.4296680122841818 0.7497352756377792 0.08876800645244132 0.12919033872387348 3.155175430183218 0.02890468137509411 0.033914216277964364 4.652003501145601e-07 6.33235996708898 0.31090775400734394 TLSSS(ph)AQEDIIR ddPTM_A459_Selumetinib_30min_R1 3 TLSSSAQEDIIR 12 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 1 T(0.011)LS(0.071)S(0.071)S(0.846)AQEDIIR;T(0.021)LS(0.076)S(0.076)S(0.827)AQEDIIR;T(0.308)LS(0.185)S(0.185)S(0.323)AQEDIIR 222.56 1.9967e-08 194317700.0 4332.3 5908.200000000001 5350.200000000001 6512.299999999999 6201.0 5014.8 6048.7 5946.9 2601.19 3805.0 True False 4433.234160811647 5216.465197352338 4623.67222654495 5375.04905601112 5640.120644875469 4964.355665074095 5592.441689163689 5789.168893746386 4414.029446599162 4293.408813838613 1.0325674430355538 1.21499382507869 1.0769233555495168 1.2519304098613064 1.3136696013424354 1.1562736930787654 1.3025644497533064 1.348385198047436 1.0280943739556694 1.0 12.067907835881776 -5.765449009537643 24.95310840362542 1.221818592536259 1.1188447658728902 0.09086298437629403 0.11889359199192868 193.29199327780995 1202922.729656495 0.0316815299384152 0.048994766156109947 1.716133189282199e-06 5.765449009537643 -0.10297382666336885 TLSSS(ph)SMDLSR ddPTM_A459_Selumetinib_30min_R1 2 TLSSSSMDLSR 11 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 TLSS(0.224)S(0.746)S(0.03)MDLSR;TLSS(0.136)S(0.612)S(0.252)MDLSR 234.24 1.0557e-07 225433000.0 10115.4 11029.6 9824.7 11551.099999999999 10259.5 9521.3 10642.7 9111.5 5757.299999999999 8219.6 True False 10351.069138857918 9738.249304478075 8490.559703214121 9533.917226001578 9331.530036461845 9425.524366648711 9839.912570513077 8869.833421676874 9769.7176034451 9274.665725684072 1.1160584591413352 1.049983858448959 0.9154572201671325 1.0279526516626436 1.0061311439635285 1.0162656688043075 1.060945252534944 0.9563507391014529 1.0533767892453627 1.0 13.179079570213487 -4.935433066967946 4.6102868544621725 1.0049324152455663 1.1092764494249459 0.4140647414515557 0.0409119630125359 0.19389328389965343 7.950000913318827 0.0099299070896238 0.04521511767794656 1.160291025263413e-05 4.935433066967946 0.10434403417937954 TLSSS(ph)SMDLSR ddPTM_A459_Selumetinib_30min_R2 3 TLSSSSMDLSR 11 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 TLS(0.015)S(0.112)S(0.84)S(0.034)MDLSR;TLSS(0.4)S(0.576)S(0.023)MDLSR;TLSS(0.039)S(0.923)S(0.039)MDLSR 242.97 9.1937e-11 156308500.0 278621.0 223225.0 256691.0 276132.0 262594.0 251680.0 215642.0 230323.0 194146.0 250886.0 True False 263136.36022823415 240345.63971849537 240175.78052402902 238522.34524573127 229604.59409985464 286346.63547643303 225669.7802865167 230993.20179797465 232980.62489247927 243642.2692998876 1.0800111203378762 0.9864693856658568 0.9857722193040657 0.9789858957197018 0.9423840730084703 1.175274866299914 0.9262341092741613 0.9480834440663339 0.9562405799369509 1.0 17.894404921388734 TLSSSS(ph)MDLSR ddPTM_A459_Selumetinib_30min_R2 1 TLSSSSMDLSR 11 0 Q9H0B6;Q9H0B6-2 Q9H0B6 KLC2 Kinesin light chain 2 1 TLSS(0.064)S(0.214)S(0.722)MDLSR 110.64 0.0087072 118150000.0 82863.0 61267.0 88481.0 89404.0 91067.0 67273.0 68875.0 73738.0 54634.0 84506.0 True False 78257.80618687088 65965.98189554515 82788.22879082873 77227.02096949778 79626.3493106904 76539.24510650858 72077.82397322329 73952.56537201688 65562.32660150484 82066.09220704374 0.9535948901945401 0.8038153166733006 1.0087994513247094 0.9410344624995971 0.970270999498817 0.9326537068855243 0.8782899494151477 0.9011342368470852 0.7988966555894765 1.0 16.32449863676122 -7.253054499652131 21.201978501462325 0.8863414000713762 0.9342921437829247 0.07484415314613624 0.06718576787406247 188.39759229257643 476384.13470946264 0.02543339472632964 0.019276468097044853 5.584001166608904e-08 7.253054499652131 0.047950743711548505 TLSVAAAFNEDEDS(ph)EPEEMPPEAK ddPTM_A459_Selumetinib_30min_R1 9 TLSVAAAFNEDEDSEPEEMPPEAK 24 0 Q8WW12 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK 162.81 2.863e-13 55507900.0 45203.79 53360.329999999994 56976.1 60591.490000000005 53978.61000000001 47641.840000000004 51022.469999999994 46293.21 27973.819999999996 44279.07 True False 46256.950355736204 47112.877757055605 49239.058567314845 50010.32371463346 49096.254256197644 47162.606344929685 47173.804009473744 45065.3636892615 47469.52941302425 49962.719949166065 0.925829306386837 0.9429606275436967 0.9855159730577618 1.00095278570734 0.982657755745684 0.9439559414082076 0.9441800618034834 0.9019797908342998 0.9500989830281762 1.0 15.60856439833598 -10.366678645128893 12.073720789246199 0.9999991618126725 0.9540175474307921 0.20056661300299683 0.028024019430505018 0.0 0.0 0.030745541473384992 0.007456889118327929 4.2985437854689086e-11 10.366678645128893 -0.04598161438188031 TLSVAAAFNEDEDS(ph)EPEEMPPEAK ddPTM_A459_Selumetinib_30min_R2 2 TLSVAAAFNEDEDSEPEEMPPEAK 24 0 Q8WW12 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 TLSVAAAFNEDEDS(1)EPEEMPPEAK;TLSVAAAFNEDEDS(1)EPEEMPPEAK 105.51 4.1252e-07 1256700.0 19430.4 15855.0 18966.6 17806.5 19877.1 15341.4 13935.9 17627.0 13124.9 15683.2 True False 18350.53615405402 17071.02751813978 17746.30960527268 15381.223982074182 17379.96099447139 17454.53859463664 14583.946963461975 17678.291651693067 15750.246740346483 15230.385266152776 1.2048635561987593 1.1208532955550083 1.1651911159930513 1.0099038017282873 1.1411373179833946 1.146033950528271 0.9575560111320747 1.1607251781726358 1.0341331795032802 1.0 13.894664816091527 -1.5228787452803376 0.15603552807153256 1.0044061676036784 1.6524240588023449 0.3387927790330908 0.06584521895410121 83.28786595961397 0.8467237759508808 0.20637364788464077 12.324730386983674 0.029999999999999995 1.5228787452803376 0.6480178911986665 TLT(ph)EPSVDFNHSDDFTPISTVQK ddPTM_A459_Selumetinib_30min_R2 1 TLTEPSVDFNHSDDFTPISTVQK 23 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 T(0.225)LT(0.699)EPS(0.077)VDFNHSDDFTPISTVQK 85.76 0.0003644 22227000.0 59715.0 54127.0 57148.0 73185.0 62998.0 64257.0 65046.0 49848.0 44420.0 63600.0 True False 56396.27935808504 58278.36685426374 53471.15989803776 63217.07674883322 55083.62803073427 73107.81848303077 68070.76788620389 49993.04942721933 53305.24119849984 61763.702747354895 0.9130974480071999 0.9435698357116321 0.8657376018526954 1.0235311993424903 0.8918446527737246 1.183669618741595 1.1021160464528512 0.8094244224915798 0.8630512554686935 1.0 15.914471624628213 -3.8109708135064952 19.182777711387654 0.9613338783664053 0.7442600585032451 0.0 0.11133824487925265 0.0 0.0 0.026950867310094467 0.0 0.0001545358290902071 3.8109708135064952 -0.2170738198631602 TLTAEEAEEEWERR ddPTM_A459_Selumetinib_30min_R1 2 TLTAEEAEEEWERR 14 1 P35269;M0R0R9 P35269 GTF2F1 General transcription factor IIF subunit 1 0 ; 196.7 0.00015390000000000005 5185200.0 1552.4499999999998 2012.21 2280.09 2372.88 1811.24 1927.99 1703.25 2022.4299999999998 1180.53 1409.02 False True 1588.6190644581488 1776.619517748951 1970.466301637861 1958.5010524741895 1647.413661800395 1908.5961710748572 1574.7724812055585 1968.7885866215177 2003.2731875002241 1589.881442017053 0.9992059926447707 1.1174540885859936 1.2393793962007427 1.2318535210961867 1.0361864842641046 1.2004644627170797 0.9904968003196981 1.2383241508396703 1.2600141963785103 1.0 10.634703471938218 TLTAEEAEEEWERR ddPTM_A459_Selumetinib_30min_R2 2 TLTAEEAEEEWERR 14 1 P35269;M0R0R9 P35269 GTF2F1 General transcription factor IIF subunit 1 0 ; 130.15 0.0013454 3606100.0 11408.5 12669.099999999999 14246.8 15793.9 12500.2 10011.9 10748.7 10191.099999999999 9143.900000000001 11540.1 False True 10774.461241843977 13640.779232422867 13330.176398743002 13642.74357400283 10929.813122794132 11390.948346020738 11248.535848144984 10220.754413772569 10972.935501912722 11206.907328219339 0.9614125401673976 1.2171760533858402 1.189460750262225 1.2173513329275045 0.9752746946762489 1.0164221057970184 1.0037145412830195 0.9120049014803927 0.9791225340359986 1.0 13.45210058473794 -6.273736929929064 24.592093825508858 0.979587881208457 1.1544884867633853 0.5503541976657076 0.07302372471017318 443.25015223676905 886389.6611343763 0.022679650665073717 0.025908827233191403 5.32430676815872e-07 6.273736929929064 0.17490060555492837 TLTDEVNS(ph)PDSDRR ddPTM_A459_Selumetinib_30min_R1 4 TLTDEVNSPDSDRR 14 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 T(0.007)LT(0.001)DEVNS(0.957)PDS(0.035)DRR;TLTDEVNS(1)PDSDRR;TLTDEVNS(0.991)PDS(0.009)DRR;TLTDEVNS(0.5)PDS(0.5)DRR 233.62 2.0132999999999999e-13 508925000.0 15041.0 19301.2 19316.0 20994.8 19278.0 15758.2 18968.5 16544.699999999997 9490.5 15124.999999999998 True False 15391.426035308723 17041.406531115557 16692.993295193122 17328.452301205765 17534.308303807346 15599.686815300814 17537.69077337303 16105.880811240459 16104.685341305078 17066.441079976095 0.901853289926237 0.9985331125134278 0.978118004624811 1.0153524229217938 1.0274144575098434 0.9140562313020135 1.0276126517056827 0.943716427799194 0.9436463798067755 1.0 14.05887461942755 -4.754578071186878 24.800037601767485 0.982863103177805 0.9018531356884638 0.3073099296208788 0.03661890335908955 272.3899297089671 984449.4495527205 0.008984207325603313 0.08592594076660283 1.7596323140952594e-05 4.754578071186878 -0.0810099674893412 TLTDEVNS(ph)PDSDRR ddPTM_A459_Selumetinib_30min_R2 5 TLTDEVNSPDSDRR 14 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 TLTDEVNS(0.996)PDS(0.004)DRR;TLTDEVNS(0.999)PDS(0.001)DRR;TLTDEVNS(0.946)PDS(0.054)DRR;TLTDEVNS(0.772)PDS(0.228)DRR;T(0.007)LTDEVNS(0.99)PDS(0.003)DRR 152.66 0.00019423 760136000.0 530963.0 512360.0 592260.0 601713.0 641719.0 452303.0 486578.0 498548.0 424250.0 538692.0 True False 501454.2020732959 551656.3645029399 554154.6364039317 519758.65138717875 561100.5221793507 514603.63265216636 509204.8411360156 499998.6921409355 509111.8545354244 523138.5622700963 0.9585494900190424 1.054512904017425 1.0592884493149288 0.9935391670072058 1.0725657839952059 0.9836851453257552 0.973365142356134 0.9557672253623435 0.9731873948007106 1.0 18.996833594185688 -6.939869198995662 10.309377316501234 0.9728343830110822 1.029028133670253 0.37339148515885845 0.03273729438807947 0.43378942479621196 71.75431870579743 0.011164133625907981 0.009844507606538405 1.1484994749924768e-07 6.939869198995662 0.05619375065917076 TLTDEVNSPDS(ph)DR ddPTM_A459_Selumetinib_30min_R2 1 TLTDEVNSPDSDR 13 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 TLTDEVNS(0.017)PDS(0.983)DR 118.08 0.0034920000000000003 11093000.0 48124.0 38558.0 52842.0 62968.0 61506.0 46074.0 40056.0 46859.0 46040.0 59724.0 True False 45449.46073563568 41515.27461648904 49442.20325001945 54391.649774141304 53779.066409383544 52420.27528187053 41918.68336945822 46995.351932074955 55249.28646508182 57999.61293841234 0.7836166214401602 0.7157853736122789 0.8524574690269107 0.9377933234123097 0.9272314707770474 0.9038038812006158 0.7227407433558243 0.8102700958018046 0.952580261591556 1.0 15.823755651967309 -12.971405346720465 0.02170970220404712 2.013001259461913 3.3032743870889077e-06 0.3152789089530773 0.07791500127343744 3244.497082826796 6.958434845977478 413.0535793366888 250.0451167188061 1.0680575473584629e-13 12.971405346720465 -2.012997956187526 TLTDEVNSPDS(ph)DRR ddPTM_A459_Selumetinib_30min_R2 1 TLTDEVNSPDSDRR 14 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 TLTDEVNS(0.232)PDS(0.768)DRR 141.06 0.0010009 82150000.0 159330.0 158430.0 180240.0 185580.0 215450.0 148040.0 166900.0 167440.0 142440.0 193160.0 True False 150475.07644852524 170581.07156725886 168643.55463047442 160303.68385664365 188383.24485256217 168431.16622668118 174661.180706076 167927.22267881565 170931.98010613036 187582.96891004834 0.8021787762655711 0.9093633209796226 0.8990344678431018 0.8545748304768226 1.004266250540568 0.8979022307054377 0.9311142782361617 0.895215720566518 0.9112340054074811 1.0 17.51716932262915 -3.535321420987737 0.8689404820607989 0.9254774591003935 1.0085880299446622e-23 0.4090975499986985 0.04389955008507283 17.488300442523286 1.8967296880999358 0.014472115898285742 25.25430038478339 0.0002915268627483723 3.535321420987737 -0.9254774591003935 TLTEPS(ph)VDFNHSDDFTPISTVQK ddPTM_A459_Selumetinib_30min_R1 1 TLTEPSVDFNHSDDFTPISTVQK 23 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 T(0.054)LT(0.218)EPS(0.728)VDFNHSDDFTPISTVQK 104.42 1.5234e-05 47675000.0 8078.7 9335.2 9143.4 8713.3 7846.3 8735.2 9455.2 8363.2 4774.3 7408.8 True False 8266.917991586239 8242.230444183257 7901.776501101104 7191.685723898112 7136.603550376775 8647.331818927023 8741.986651574809 8141.3807684978365 8101.638398924483 8359.791647823262 0.9888904340981745 0.9859373045893296 0.9452121337448145 0.8602709286146738 0.8536819876647306 1.0343956145340814 1.0457182451252913 0.973873645597101 0.9691196551571956 1.0 13.029251270939787 -6.784165450351629 24.99994853192583 1.0055570927921362 0.9274110041552773 0.4045915244706859 0.04719395611742463 281.8071080337392 310001.4103439245 0.018963692750218794 0.0167360399120774 1.643745396897412e-07 6.784165450351629 -0.0781460886368589 TLTEPS(ph)VDFNHSDDFTPISTVQK ddPTM_A459_Selumetinib_30min_R2 1 TLTEPSVDFNHSDDFTPISTVQK 23 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 T(0.017)LT(0.067)EPS(0.915)VDFNHS(0.001)DDFTPISTVQK 92.198 0.00010708 21627000.0 51491.0 42020.0 49653.0 57530.0 54654.0 53884.0 49142.0 54338.0 40848.0 51331.0 True False 48629.3363548046 45242.79888440449 46458.38003809879 49694.31475521448 47787.87590704074 61306.03188974935 51427.20037302567 54496.114583859846 49018.74138848092 49848.940656045175 0.9755339976097833 0.9075980008597816 0.9319832964688044 0.9968981105958178 0.9586537903939492 1.229836202794307 1.0316608476771933 1.0932251290931116 0.9833456988927292 1.0 15.605275225667219 -6.572242529184889 24.999997876480354 1.0737545872845242 0.9519475190437255 0.41542003078922674 0.06713292002525752 102.51844297934544 51919.13412360926 0.021565428838974464 0.02156543331090329 2.6776725767980214e-07 6.572242529184889 -0.12180706824079868 TLTEPSVDFNHS(ph)DDFTPISTVQK ddPTM_A459_Selumetinib_30min_R1 1 TLTEPSVDFNHSDDFTPISTVQK 23 0 Q6R327-3;Q6R327 Q6R327-3 RICTOR Rapamycin-insensitive companion of mTOR 1 T(0.009)LT(0.048)EPS(0.373)VDFNHS(0.57)DDFTPISTVQK 92.819 7.791e-05 16921000.0 841.51 762.89 959.91 891.35 649.19 786.69 793.44 722.15 593.32 520.13 True False 861.1155457065778 673.5704841420609 829.5594944082021 735.6924552117549 590.4708791238037 778.7766128573699 733.590181997791 702.9962361262089 1006.8207056217408 586.8937519952374 1.4672426529999347 1.147687263413782 1.41347474153198 1.2535360151827362 1.006095016544997 1.3269465047290019 1.2499539814554783 1.1978253878768736 1.7155076233115378 1.0 9.196955539202838 TLTLVDTGIGMTK ddPTM_A459_Selumetinib_30min_R2 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 134.98 0.016228 3736100.0 34130.0 34077.0 35195.0 35522.0 36117.0 23672.0 27479.0 27340.0 19428.0 27881.0 False True 32233.191233215144 36690.59632517498 32930.59201741863 30683.842321132124 31579.659569923348 26932.603126979193 28756.827948605525 27419.554873619352 23314.14286367527 27076.003086462308 1.1904708065767422 1.3550964744689313 1.2162279606875785 1.1332485900207958 1.166333873913348 0.9947037988204834 1.0620780274243509 1.01268842325287 0.8610629415732367 1.0 14.724727165990924 -6.476470974540161 0.679493109262005 0.9520188921900654 1.2891537726042284 0.7649270557675496 0.06495936939854649 0.3566998963681641 0.36490389575575727 0.04371328340007397 0.06222225267532015 3.338328156663475e-07 6.476470974540161 0.33713488041416295 TLTRTS(ph)QETADVK ddPTM_A459_Selumetinib_30min_R1 1 TLTRTSQETADVK 13 1 H3BNN5;H3BV11;H3BRI8;H3BM93;H3BVG0;Q8N1F7 H3BNN5 NUP93 Nuclear pore complex protein Nup93 1 T(0.084)LT(0.084)RT(0.059)S(0.74)QET(0.033)ADVK 111.07 0.025522 13091000.0 2240.1 2295.3 5909.5 6478.7 3500.9 3385.0 2588.0 2157.9 1593.5 1334.8 True False 2292.289971524172 2026.565208943981 5107.02235855994 5347.316665261006 3184.2442131340963 3350.949973334089 2392.7850763892466 2100.665482152943 2704.053115364799 1506.134582053031 1.5219688856752247 1.3455405865401115 3.3908140875422257 3.550357802668611 2.1141830558021004 2.2248675604847787 1.5886927402779711 1.394739558592101 1.7953595565668974 1.0 10.556634973785826 -7.2025099199525675 2.0212797334791754 1.433633958226065 2.4446162892508188 0.30730355349707894 0.6779542951799641 0.48402345183253087 3.869866253839892 0.3707413083591927 0.2477658400391813 6.273213668374915e-08 7.2025099199525675 1.0109823310247537 TLVITSTPAS(ph)PNR ddPTM_A459_Selumetinib_30min_R1 1 TLVITSTPASPNR 13 0 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 TLVITSTPAS(0.999)PNR 182.37 0.00011758 10058000.0 3419.4 4245.6 3001.3 3436.4 3999.4 3511.3 3645.9 3640.7 2098.7 3168.4 True False 3499.065367005827 3748.523178274107 2593.739944960816 2836.2972492171148 3637.654976151418 3475.979510005318 3370.886827669069 3544.1368093397377 3561.340617016696 3575.095002829506 0.9787335341400702 1.048510088629069 0.7255023832675782 0.7933487772974787 1.0174988282192219 0.9722761233629474 0.9428803500329875 0.9913405955743088 0.9961527215914754 1.0 11.803765864536302 -6.2862103572337835 24.89934870986311 0.9833471487920662 0.8865926088535493 0.24808098248645472 0.08531316723163229 1221.242235809968 1227567.6821594543 0.029035527202663388 0.0329374967701079 5.173561818025036e-07 6.2862103572337835 -0.0967545399385169 TLVITSTPAS(ph)PNR ddPTM_A459_Selumetinib_30min_R2 4 TLVITSTPASPNR 13 0 E9PK89;Q8TBN0 E9PK89 RAB3IL1 Guanine nucleotide exchange factor for Rab-3A 1 T(0.005)LVIT(0.375)S(0.059)T(0.042)PAS(0.519)PNR;TLVIT(0.096)S(0.015)T(0.067)PAS(0.822)PNR;TLVIT(0.004)S(0.001)T(0.001)PAS(0.993)PNR;TLVIT(0.058)S(0.058)T(0.058)PAS(0.827)PNR 114.21 0.004305600000000001 31017500.0 204896.0 195148.0 210859.0 247916.0 258066.0 183129.0 220255.0 206286.0 184697.0 214235.0 True False 193508.70058367585 210115.22410027968 197292.56150592043 214149.4131210457 225645.44194068795 208353.35747045313 230497.29392700284 206886.2581075144 221641.56086536124 208049.47890062223 0.9301090375530717 1.0099291053771118 0.9482963502165752 1.0293196322944755 1.0845758573058992 1.0014606072143832 1.107896521274649 0.9944089223426344 1.0653310070112287 1.0 17.666567149320663 -5.859726061220732 5.471721768784508 1.044278855700849 0.9678225822376166 0.4409833920525229 0.040038780787061745 0.1821054527601246 8.315204286771326 0.010505930962779466 0.015896298786373494 1.381255240589539e-06 5.859726061220732 -0.07645627346323247 TLVLSSS(ph)PTSPTQEPLPGGK ddPTM_A459_Selumetinib_30min_R2 1 TLVLSSSPTSPTQEPLPGGK 20 0 H0YI02;J3KPG1;Q96QF0-8;Q96QF0-5;Q96QF0-7;Q96QF0-6;Q96QF0-3;Q96QF0-4;Q96QF0-2;Q96QF0 H0YI02 RAB3IP Rab-3A-interacting protein 1 TLVLS(0.018)S(0.098)S(0.812)PT(0.066)S(0.006)PTQEPLPGGK 174.35 1.1942e-11 0.0 18408.0 22264.0 21316.0 23309.0 25526.0 22201.0 21925.0 17879.0 18565.0 19970.0 True False 17384.95705306253 23971.577209956722 19944.551767106008 20134.273989732217 22319.19567466464 25258.986229387658 22944.555943563293 17931.024929972205 22278.51874944057 19393.41421170877 0.8964361232776831 1.2360679222477438 1.0284187997729914 1.0382016167929913 1.150864692055586 1.3024517474668051 1.183110704133289 0.9245935106746884 1.1487672313000936 1.0 14.243279191900468 -4.739425486419115 24.81174836362494 1.114533419560541 0.8964351864260415 0.2596086363671579 0.10941483249088904 2417.093172638432 2724139.595866717 0.028097594212159772 1.3875545149776887 1.822109672665067e-05 4.739425486419115 -0.2180982331344995 TLVLSSSPT(ph)SPTQEPLPGGK ddPTM_A459_Selumetinib_30min_R2 1 TLVLSSSPTSPTQEPLPGGK 20 0 H0YI02;J3KPG1;Q96QF0-8;Q96QF0-5;Q96QF0-7;Q96QF0-6;Q96QF0-3;Q96QF0-4;Q96QF0-2;Q96QF0 H0YI02 RAB3IP Rab-3A-interacting protein 1 TLVLSSS(0.012)PT(0.961)S(0.019)PT(0.009)QEPLPGGK 154.23 9.8659e-06 3132300.0 30759.0 24188.0 26757.0 31014.0 29031.0 21581.0 23061.0 27144.0 20809.0 30228.0 True False 29049.537918032933 26043.141823321672 25035.483750818865 26789.839697865853 25383.866239567084 24553.586857187318 24133.382194504597 27222.984546068878 24971.381452039248 29355.23909822397 0.989586145792642 0.8871718515451409 0.8528455062842102 0.912608465161051 0.864713319303294 0.8364294623876132 0.8221149932982388 0.9273637477446369 0.8506618313849826 1.0 14.84133038702453 -4.765550163621505 4.687170176970907 0.8768248960850442 0.9977346848419727 0.28018562265759284 0.05004156738994144 0.22027259303071367 11.409820846651087 0.011739691818085953 0.08877610500301221 1.715733521146952e-05 4.765550163621505 0.12090978875692848 TLYS(ph)FFSPSPAR ddPTM_A459_Selumetinib_30min_R1 1 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 TLYS(0.528)FFS(0.316)PS(0.156)PAR 113.95 0.0057429 24384000.0 1762.0 1575.6 1975.5 2143.8 1920.2 1897.7 1804.2 1688.0 1058.3 1406.0 True False 1803.0511717448298 1391.1280195234324 1707.237950644752 1769.4255741100133 1746.518249038845 1878.610860973739 1668.107741430246 1643.2287566032567 1795.8578048262113 1586.4737955997605 1.136514940710504 0.8768679466259458 1.0761211155078279 1.1153197607282814 1.1008806157926991 1.1841423830536937 1.0514562207437055 1.0357742820341007 1.1319807549341172 1.0 10.631607976563403 -5.496590504109842 24.90584636397127 1.093167567567411 0.999142200501943 0.1495594824015437 0.07607192358490263 1034.5186470861024 980115.5128941855 0.018814407008238918 0.03895487255136833 3.1872013147208535e-06 5.496590504109842 -0.09402536706546805 TLYSFFS(ph)PSPAR ddPTM_A459_Selumetinib_30min_R1 2 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 TLYSFFS(1)PSPAR;TLYSFFS(1)PSPAR 220.32 3.2171e-08 64469000.0 3513.6 4036.3 4175.6 4093.5 4121.5 3413.1 3786.5 3451.7 2204.28 2919.0 True False 3595.4600437245367 3563.72811957504 3608.576454928995 3378.647069511775 3748.7110527099253 3378.7673128468514 3500.88125647136 3360.1497032982584 3740.5021657585958 3293.6820834677847 1.091623281363884 1.0819891019423875 1.0956055756084604 1.0257963531059846 1.138152061343777 1.0258328603741511 1.0629080669453754 1.020180338644127 1.1356597482597266 1.0 11.685485592993137 -6.813834391175903 24.999977894658503 1.0510520190342 1.0834951611861077 0.16198541504466202 0.04245700334608998 211.41393241748196 100873.48610732458 0.01408569018276388 0.012422424027156004 1.5352022874422937e-07 6.813834391175903 0.03244314215190758 TLYSFFS(ph)PSPAR ddPTM_A459_Selumetinib_30min_R2 2 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 TLYSFFS(1)PSPAR;TLYSFFS(1)PSPAR 201.08 8.4836e-05 32566000.0 51622.0 55898.0 55383.0 61575.0 63138.0 48927.0 53953.0 53482.0 43349.0 48919.0 True False 48753.05589923917 60185.19685960124 51819.7180764511 53188.37877720034 55206.03997911842 55666.25013491511 56461.92140584128 53637.62376557828 52020.01127225956 47506.581363173784 1.0262379337830363 1.2668812432429768 1.090790298723132 1.1196002164540297 1.1620714097923517 1.171758702428261 1.188507355943097 1.1290566954404588 1.0950064134184259 1.0 15.535839771778106 -8.610970929561296 1.879175620154418 1.0005973945577973 1.1494977086880978 0.35262851832626463 0.05978875882350871 0.4630732956679565 3.5726610041173723 0.05358021964084564 0.01506051289721703 2.4492271806666332e-09 8.610970929561296 0.14890031413030047 TLYSFFSPS(ph)PAR ddPTM_A459_Selumetinib_30min_R1 1 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 TLYSFFS(0.043)PS(0.957)PAR 209.22 7.3203e-06 25474000.0 794.99 785.91 1129.9 988.76 824.98 763.56 923.34 786.61 328.03 650.74 True False 813.5117202187407 693.8952918403531 976.4657860964336 816.0916273239186 750.3607046620485 755.8792796570096 853.6917204147007 765.7465475306202 556.6429516367208 734.2688177443737 1.107920833023791 0.94501533371927 1.3298478193532355 1.1114344060406913 1.021915525389064 1.0294312673919912 1.162641936827968 1.042869490063522 0.7580915029820985 1.0 9.520164523996774 -8.071979864099028 6.574539099292605 0.8820490108746828 1.0989254053108348 0.38715597712435657 0.11018884256337942 0.2519268161891818 18.81079877926599 0.07420206601625376 0.027792133955196308 8.4726669643294e-09 8.071979864099028 0.21687639443615203 TLYSFFSPS(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 1 TLYS(0.005)FFS(0.046)PS(0.949)PAR;TLYSFFS(0.045)PS(0.955)PAR 86.539 0.02975 20761000.0 131678.0 120793.0 130145.0 143092.0 116951.0 90671.0 125652.0 107211.0 88703.0 109709.0 True False 124359.86390879872 130057.43468928781 121771.61239116215 123602.62275253194 102258.56982479454 103160.10722061203 131495.06697471446 107522.96626026345 106446.07856889983 106541.41611178554 1.167244330395587 1.2207218510483169 1.1429509465445509 1.1601368487804349 0.9598011135641623 0.9682629627559505 1.2342154982879805 1.0092128505918116 0.9991051597926418 1.0 16.70105483638124 -6.140899579952783 6.4855689322196355 1.03644818533807 1.1763684165679276 0.46894156021461475 0.07505961925280959 0.24402116217738373 12.003858731101817 0.023266604013772108 0.030208782640302894 7.229369458817156e-07 6.140899579952783 0.13992023122985753 TMCPLLSMKPGEYSYFS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TMCPLLSMKPGEYSYFSPR 19 1 C9J470;E9PHA2;Q15003;Q15003-2 C9J470 NCAPH Condensin complex subunit 2 1 TMCPLLSMKPGEYSYFS(1)PR 116.27 0.00025748 28084000.0 2057.9 2579.8 2469.6 3015.1 2554.6 2045.1 2278.5 2073.7 1345.8 1928.2 True False 2105.845066023657 2277.7558166835183 2134.2418845417756 2488.569385436654 2323.5368810512614 2024.5281508022297 2106.6309105691266 2018.6987396730865 2283.7243066570104 2175.703252258505 0.9678916754100859 1.0469055530983267 0.9809434638323539 1.14380000252947 1.0679475147354294 0.9305166725750182 0.9682528664616016 0.9278373498672492 1.049648799433642 1.0 11.087266083120983 -6.753808070319416 24.99924355893317 0.9703035782574523 1.044117428760408 0.25936905743760696 0.055571317185756884 229.96698625002117 753343.2596898022 0.01874573355285895 0.018405918724306435 1.7627548963638727e-07 6.753808070319416 0.07381385050295575 TMELS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TMELSPR 7 0 Q15911;Q15911-2 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 TMELS(1)PR;TMELS(1)PR 98.582 0.021764 13251200.0 79083.0 76393.0 83909.0 92155.0 79453.0 72533.0 79467.0 83749.0 60328.0 70710.0 True False 74687.88345433201 82252.09745778964 78510.38629321136 79603.33002375804 69471.40382116783 82523.76236098257 83162.37296087321 83992.6957246066 72395.28570515753 68668.41857335625 1.0876598734328702 1.1978155193704132 1.1433259702834317 1.1592422204789874 1.0116936615768102 1.2017717034334365 1.2110716205300918 1.2231633911137756 1.0542733793675472 1.0 16.067359118427817 -8.473289678247093 5.576292168660085 1.0003059591918906 1.1540704200316114 0.42457495933022527 0.06089767007417817 0.17143794975302667 11.970141064842753 0.06046959095211388 0.015695529098101926 3.362871880333505e-09 8.473289678247093 0.15376446083972084 TMFAQVES(ph)DDEEAK ddPTM_A459_Selumetinib_30min_R2 3 TMFAQVESDDEEAK 14 0 Q9NW82 Q9NW82 WDR70 WD repeat-containing protein 70 1 TMFAQVES(1)DDEEAK;TMFAQVES(1)DDEEAK;TMFAQVES(1)DDEEAK 174.49 1.6823e-06 5362500.0 54157.0 40368.0 39858.0 41671.0 40698.0 34602.0 56746.0 56659.0 42689.0 37783.0 True False 51147.17074764818 43464.09579642171 37293.57967410917 35995.33791351546 35585.15339526373 39368.111414317915 59384.8014400658 56823.868309597594 51227.99283031879 36692.10661797657 1.3939556886218585 1.1845625613419355 1.016392437272542 0.9810103924608204 0.9698312982070507 1.072931347992712 1.6184625772064936 1.5486673714656074 1.3961583989625892 1.0 15.163182116516952 -7.243085415226827 24.367730530814967 1.436544363557457 1.0912657789136098 0.3380183217249768 0.19262348509443686 573.2195204524367 761038.5695129111 0.07412057426915203 0.0572879891597977 5.7136625168987864e-08 7.243085415226827 -0.3452785846438473 TMFAQVES(ph)DDEEAKNEPEWK ddPTM_A459_Selumetinib_30min_R1 2 TMFAQVESDDEEAKNEPEWK 20 1 Q9NW82 Q9NW82 WDR70 WD repeat-containing protein 70 1 T(0.002)MFAQVES(0.998)DDEEAKNEPEWK;T(0.025)MFAQVES(0.975)DDEEAKNEPEWK 75.054 0.0034262 20968000.0 2919.7 3210.1 3342.5 3947.8 3164.2 3167.9 3032.2 2749.2 1925.92 3124.3 True False 2987.7233292527667 2834.259999664998 2888.6068590382606 3258.3908393840416 2877.9986686848833 3136.0338022230612 2803.4787127617747 2676.282285339854 3268.145576368607 3525.3343382591297 0.8475007027923925 0.8039691353259287 0.8193852219034362 0.9242785298466445 0.8163760916095374 0.8895706055986986 0.7952376835117944 0.7591570127959687 0.9270455686715018 1.0 11.783544372038783 -8.505364944983738 6.179454034918561 0.9999274329838247 0.8340889703462342 0.6027955617740615 0.04469051232299674 0.0939208494006402 15.589763313252465 0.04388394318519812 0.011370211588994223 3.1234535732696373e-09 8.505364944983738 -0.1658384626375905 TMFAQVES(ph)DDEEAKNEPEWK ddPTM_A459_Selumetinib_30min_R2 2 TMFAQVESDDEEAKNEPEWK 20 1 Q9NW82 Q9NW82 WDR70 WD repeat-containing protein 70 1 T(0.005)MFAQVES(0.995)DDEEAKNEPEWK;T(0.004)MFAQVES(0.996)DDEEAKNEPEWK 72.316 0.0048031 25650000.0 95554.0 95069.0 79784.0 77180.0 76796.0 55157.9 76970.0 68760.0 57651.0 84500.0 True False 90243.49121296927 102360.48660498469 74650.78430225114 66667.95085707381 67148.19991504912 62755.400051436554 80549.25751316152 68960.08021616923 69182.8109035279 82060.26544263352 1.0997221459886266 1.2473818607928169 0.9097068343562429 0.8124267024663705 0.8182790971105365 0.764747709661108 0.9815866068514205 0.8403589708636473 0.8430732039477992 1.0 16.324396200513405 -5.354103343120206 5.037417354710624 0.8584669164022314 1.1720282347950306 0.7090352723074953 0.07754874460392157 0.10045603588301658 4.095296811857335 0.019822001364199687 0.04300857322817545 4.424830681880955e-06 5.354103343120206 0.3135613183927992 TMIIS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 TMIISPER 8 0 O75533;B4DGZ4;A0A494C1M2;O75533-2 O75533 SF3B1 Splicing factor 3B subunit 1 1 T(0.002)MIIS(0.998)PER;TMIIS(1)PER 86.882 0.03325 72204000.0 6939.700000000001 10102.8 5362.6 5167.4 6739.200000000001 5974.1 8597.9 7937.700000000001 3980.1 7604.6 True False 7101.381507694433 8919.959479335703 4634.388374653275 4265.010594111428 6129.6405499023995 5914.005978048803 7949.353480790997 7727.166410716627 6753.939004997448 8580.724485076778 0.8275969610776859 1.0395345398688545 0.5400929003970703 0.49704551189458984 0.7143500016301424 0.6892198891054228 0.9264198488852737 0.9005261064092406 0.7871059159099683 1.0 13.066883746711122 -7.260262161629444 24.960030615259384 0.8952234813867728 0.7142973767501556 0.2717464373344126 0.14847872832102524 167.0095086775912 3541077.5125367297 0.06495021152279107 0.04745360247908099 5.4920924391011e-08 7.260262161629444 -0.18092610463661718 TMIIS(ph)PER ddPTM_A459_Selumetinib_30min_R2 2 TMIISPER 8 0 O75533;B4DGZ4;A0A494C1M2;O75533-2 O75533 SF3B1 Splicing factor 3B subunit 1 1 TMIIS(1)PER;TMIIS(1)PER 106.88 0.013539 4569700.0 40979.0 28626.0 39787.0 40728.0 42807.0 32487.0 36557.0 39681.0 32982.0 36220.0 True False 38701.55123193444 30821.522152902522 37227.147736810184 35180.776140281174 37429.2019605645 36961.78936237633 38256.972936321275 39796.46514045682 39579.32159407749 35174.23448913826 1.1002812653644363 0.8762528197286042 1.0583641201432787 1.000185978493574 1.0641085016966771 1.0508200078608694 1.0876419484874635 1.1314095592541153 1.1252361897541654 1.0 15.102231405406663 -6.49778362513278 1.1118729502666596 1.095067737373032 0.9961533024679172 0.20342726161690128 0.0641546380402639 0.6290417725291617 1.646455007772288 0.028808863864971085 0.033849973958437043 3.178457252108383e-07 6.49778362513278 -0.09891443490511476 TMIIS(ph)PERLDPFADGGK ddPTM_A459_Selumetinib_30min_R2 2 TMIISPERLDPFADGGK 17 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 T(0.124)MIIS(0.876)PERLDPFADGGK;TMIIS(1)PERLDPFADGGK 130.64 0.0040133 39800000.0 109259.3 137634.2 127037.3 131593.2 136338.8 100477.2 109164.9 105560.4 98731.6 130898.3 True False 103187.10550563215 148190.30057629463 118863.85842575438 113669.97914906824 119210.70105966325 114317.0222587914 114241.28415614572 105867.56328753494 118480.67879139574 127118.92596437242 0.8117367632145693 1.165761112690866 0.9350602793723125 0.8942018530028053 0.9377887687084013 0.8992919141783104 0.8986961090920803 0.8328229843383542 0.9320459395999167 1.0 16.9558193148682 -5.5071515722728135 24.902641450516004 0.9070155506667164 1.004164374095554 0.09223569826439415 0.08897140321788025 1081.0197174085718 1711699.819356477 0.021750509708336092 0.043206618170059864 3.1106305125285025e-06 5.5071515722728135 0.09714882342883757 TMIISPERLDPFADGGKT(ph)PDPK ddPTM_A459_Selumetinib_30min_R1 1 TMIISPERLDPFADGGKTPDPK 22 2 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 T(0.001)MIIS(0.037)PERLDPFADGGKT(0.962)PDPK 80.596 0.003752 12734000.0 1948.8 1393.4 3496.6 4109.1 2445.9 2303.4 1618.8 1839.1 1255.5 1283.7 True False 1994.2032482953032 1230.2600802259146 3021.7809254489716 3391.5228223600398 2224.668776858718 2280.229887319866 1496.6926126966425 1790.3210937612844 2130.4918019080665 1448.4753992968808 1.3767601778140863 0.8493482739320997 2.0861803568882187 2.3414431643135627 1.5358692166526384 1.574227555695275 1.033288251511325 1.2360037972549223 1.4708512156590647 1.0 10.500319466948152 -7.1318604627733215 5.0765200852996655 1.2064946689196834 1.6489310044661971 0.23317754700520743 0.39266642606654995 0.4058515981062585 15.046423482632228 0.16899772710438318 0.13021149232359405 7.381413541475855e-08 7.1318604627733215 0.44243633554651374 TMQFEPSTMVY(ph)DACR ddPTM_A459_Selumetinib_30min_R1 1 TMQFEPSTMVYDACR 15 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 TMQFEPS(0.009)T(0.174)MVY(0.816)DACR 115.8 0.023649 0.0 1271.8 1213.9 1249.6 1433.1 986.92 966.41 916.48 1037.3 449.19 664.57 True False 1301.4304655079868 1071.7760236732004 1079.9111835614685 1182.8359876187433 897.6532602548778 956.6887928300736 847.3491757377185 1009.7874343747372 762.2426224604418 749.8740329599813 1.7355321138016264 1.4292747535777095 1.4401234555338982 1.5773795806073312 1.1970720691734942 1.2757993353280037 1.12998868942424 1.3466094170360836 1.0164942229718743 1.0 9.550504455667035 -1.5228787452803416 0.1611892497758607 0.9329690093305073 3.808799483329992 0.7555661201070842 0.11202416969691177 31.22810857554992 0.32520379762164514 0.32341141332177675 21.35509437639 0.02999999999999972 1.5228787452803416 2.8758304739994847 TMS(ph)QGEITK ddPTM_A459_Selumetinib_30min_R1 1 TMSQGEITK 9 0 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 T(0.176)MS(0.824)QGEIT(0.001)K 93.623 0.024322 13815000.0 1590.1 1859.8 1966.6 2236.8 1858.2 1809.1 1991.4 1708.9 971.07 1354.0 True False 1627.146236204003 1642.053751402436 1699.546521760551 1846.1848699362247 1690.1261380918556 1790.9020965313744 1841.1870947146613 1663.5744207104892 1647.83486585334 1527.799089076868 1.0650263165081233 1.0747838267102277 1.1124149332930005 1.208395058706137 1.1062489499932018 1.17221047540582 1.205123833283046 1.0888698864951278 1.078567776113154 1.0 10.577239121065865 -8.496050575480492 1.8160753487004846 1.0025085964092595 1.134007154826919 0.4157916896358639 0.04797925326659539 0.36367395985182943 2.682126219503163 0.0489885974446617 0.01396155980608048 3.1911662082828414e-09 8.496050575480492 0.13149855841765956 TMS(ph)SDDEDCSAK ddPTM_A459_Selumetinib_30min_R1 2 TMSSDDEDCSAK 12 0 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 TMS(0.638)S(0.362)DDEDCSAK;T(0.007)MS(0.642)S(0.352)DDEDCSAK 213.99 2.1445e-06 31118000.0 6474.1 6772.1 7502.8 7568.799999999999 6656.4 5724.2 6123.1 6809.1 3973.8 5657.3 True False 6624.933933594323 5979.219383736126 6483.960969930366 6247.051163972322 6054.329795282872 5666.619745157759 5661.229637263908 6628.5005489260875 6743.248365131246 6383.469561768515 1.0378265094693915 0.9366723418791718 1.0157424433827817 0.9786294276997541 0.948438734875951 0.8877021642111261 0.8868577789059728 1.0383852362397241 1.056361011810489 1.0 12.640125059593261 -7.801835021133699 24.99523041846767 1.0355300490601917 0.955492031407768 0.34838256726731753 0.0472852468491718 181.66731082221244 112406.24496199185 0.027512908282795935 0.013217012538791968 1.5782106831658624e-08 7.801835021133699 -0.0800380176524238 TMS(ph)SDDEDCSAK ddPTM_A459_Selumetinib_30min_R2 1 TMSSDDEDCSAK 12 0 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 T(0.005)MS(0.498)S(0.498)DDEDCSAK 241.35 2.0078e-13 23315000.0 77427.0 67496.0 72635.0 78263.0 78209.0 51612.0 62420.0 68677.0 48913.0 65550.0 True False 73123.91730483888 72672.72616615327 67961.7431790083 67603.44438879467 68383.68622266896 58721.08451291187 65322.65368288352 68876.83869991059 58696.96674340888 63657.40118064641 1.1487103769336808 1.1416225736253864 1.0676173063701906 1.0619887575515408 1.074245648649877 0.9224549451252918 1.0261596055030817 1.0819926265046935 0.9220760768545851 1.0 15.958040639565612 -5.4998305080107714 0.7156676781920926 0.9980105296222933 1.1844285639608307 0.5671762457159988 0.049065904653948986 1.0492596773178884 0.765298132136624 0.0239862709138627 0.13665348084910056 3.1635120422652917e-06 5.4998305080107714 0.18641803433853743 TMSS(ph)DDEDCSAK ddPTM_A459_Selumetinib_30min_R2 2 TMSSDDEDCSAK 12 0 H0YBW3;Q9NVR2 H0YBW3 INTS10 Integrator complex subunit 10 1 T(0.055)MS(0.046)S(0.898)DDEDCS(0.001)AK;TMS(0.11)S(0.89)DDEDCSAK 217.91 4.5354e-08 31428600.0 70123.0 58272.0 67571.0 67162.0 62989.0 51661.0 62551.0 64341.0 44218.0 63700.0 True False 66225.84438461022 62741.27502598805 63223.555425742205 58014.41973908769 55075.75869119532 58776.83381813415 65459.745442455096 64528.22165777401 53062.83555414827 61860.8154875237 1.070562097552155 1.0142329119253515 1.0220291298696724 0.9378217742827563 0.8903173722677998 0.9501464433489155 1.0581778614874102 1.0431194795805478 0.8577778216462433 1.0 15.916738231600158 -5.629879712250087 5.326271122847004 0.964910787005706 1.0367360374774868 0.24124157954162462 0.05977574114786375 0.34016847341452616 14.59207887108238 0.017408198168196304 0.03069986514237566 2.344878192817227e-06 5.629879712250087 0.07182525047178079 TNATSPGVNSST(ph)SPQSTDK ddPTM_A459_Selumetinib_30min_R1 2 TNATSPGVNSSTSPQSTDK 19 0 B7ZM87;O75044 B7ZM87 SRGAP2 SLIT-ROBO Rho GTPase-activating protein 2 1 TNATSPGVNS(0.121)S(0.121)T(0.451)S(0.307)PQSTDK;TNAT(0.007)S(0.057)PGVNS(0.01)S(0.01)T(0.866)S(0.049)PQSTDK 202.81 2.8002e-15 16333200.0 5188.9 5922.5 6149.2 6205.9 5305.6 5066.2 5251.2 4977.4 2909.96 4424.9 True False 5309.791274158196 5229.09094670445 5314.172415137796 5122.156064170786 4825.709416779762 5015.23862774156 4855.097756234623 4845.383183126213 4937.989584930623 4992.879017175946 1.063472849210254 1.0473097643095126 1.0643503271071806 1.025892285102466 0.9665183955346995 1.004478300092731 0.972404446318979 0.970458760658463 0.9890064565841675 1.0 12.285656233702426 -6.0350676419951 3.6042252215155464 0.9829764152358331 1.0567404125346636 0.877528984743907 0.012566961326817337 0.07171435241688802 1.9433782739931413 0.0036586971005470735 0.005160647328219867 9.224277465071691e-07 6.0350676419951 0.07376399729883043 TNATSPGVNSST(ph)SPQSTDK ddPTM_A459_Selumetinib_30min_R2 4 TNATSPGVNSSTSPQSTDK 19 0 B7ZM87;O75044 B7ZM87 SRGAP2 SLIT-ROBO Rho GTPase-activating protein 2 1 T(0.003)NAT(0.003)S(0.012)PGVNS(0.099)S(0.367)T(0.513)S(0.003)PQSTDK;TNATSPGVNS(0.009)S(0.009)T(0.939)S(0.042)PQSTDK;TNATSPGVNSS(0.001)T(0.892)S(0.106)PQSTDK;TNATSPGVNS(0.007)S(0.007)T(0.719)S(0.267)PQSTDK 250.39 2.4898999999999998e-37 31530900.0 143840.0 141023.0 150856.0 163237.0 148248.0 121187.0 129295.0 131093.0 108489.0 142603.0 True False 135845.9486371424 151839.01063958544 141150.08919959364 141003.83900046817 129623.76088606453 137879.4092239452 135307.47369318194 131474.4589263855 130189.83143593083 138485.68086290947 0.9809385908397258 1.0964239024097717 1.0192395944481922 1.0181835271478463 0.9360084023010466 0.9956221348287666 0.9770502831056322 0.9493722246745167 0.9400959768888242 1.0 17.079377286696555 -6.075725193336194 4.134273271912809 0.9659115580235115 1.036544157275809 0.45824133188732574 0.033241197069043035 0.19017775963737657 6.119244852761174 0.009669364013374059 0.01306231522901327 8.399913361206826e-07 6.075725193336194 0.07063259925229748 TNDTY(ph)MKFS(ph)WLT(ph)VPEES(ph)LDK ddPTM_A459_Selumetinib_30min_R1 1 TNDTYMKFSWLTVPEESLDK 20 1 A0A5H1ZRR0;P03986 A0A5H1ZRR0 TRGC2 T-cell receptor gamma-2 chain C region 4 T(0.006)NDT(0.189)Y(0.893)MKFS(0.914)WLT(0.998)VPEES(1)LDK 48.477 0.043076 0.0 478.08 452.57 652.19 619.97 403.02 492.2 440.46 460.2 373.5 389.11 True False 489.2183338182563 399.5828940059151 563.626180223235 511.70387777823714 366.5669121589601 487.2489148818431 407.2357475836196 447.9940010597267 633.8022206393179 439.0560587523637 1.1142502741186067 0.9100953876855341 1.283722588465933 1.165463652255049 0.8348977422168113 1.1097646989918004 0.927525630191357 1.0203571779256648 1.4435564844278685 1.0 8.778261344844477 TNEKVELQELNDR ddPTM_A459_Selumetinib_30min_R2 1 TNEKVELQELNDR 13 1 P08670;B0YJC4;A0A1B0GTT5;P17661 P08670 VIM;DES Vimentin;Desmin 0 142.39 0.0021922 27130000.0 70449.0 72499.0 63085.0 76973.0 65340.0 37586.0 32366.0 30752.0 28104.0 79247.0 False True 66533.72660969154 78059.440178973 59026.17978175462 66489.14461416869 57131.4050529886 42763.130328262894 33871.08313201232 30841.48322873233 33725.58529136966 76958.93320156667 0.8645354586118028 1.0142999250590434 0.7669828222170965 0.8639561626981487 0.7423622271809969 0.5556616827868445 0.4401189273673923 0.40075247857131785 0.4382283367031275 1.0 16.231801180275433 -6.589988305047328 2.038027749094974 0.5153147038291284 0.8838820333666972 0.411274698413456 0.17065986417138443 0.2717531389807777 2.2956379754236935 0.06145310244139998 0.06347120067561972 2.5704650009215935e-07 6.589988305047328 0.3685673295375689 TNGHS(ph)PSQPR ddPTM_A459_Selumetinib_30min_R2 1 TNGHSPSQPR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 T(0.01)NGHS(0.941)PS(0.048)QPR 111.79 0.008631999999999999 1734200.0 968.11 477.23 891.28 2088.5 1595.2 767.08 3766.5 10450.0 3288.2 7391.1 True False 914.3063218513894 513.8320064636924 833.936015152291 1804.042697136547 1394.7967147310605 872.7383071410613 3941.6497131781584 10480.407769909367 3945.9318799844036 7177.699738615953 0.12738152265306257 0.07158728076897412 0.11618429936066058 0.2513399505179654 0.1943236364746589 0.1215902502086759 0.549152215433605 1.4601346046178105 0.5497488086267149 1.0 12.80930585748587 -7.518254158324798 4.805315031173577 1.0111887272277689 0.1584345181975072 0.7689067963761254 0.21029636260820148 0.08007290536596544 5.143999853849346 0.09152181686715993 0.05518061776279673 3.032116206273969e-08 7.518254158324798 -0.8527542090302617 down TNGHSPS(ph)QPR ddPTM_A459_Selumetinib_30min_R2 1 TNGHSPSQPR 10 0 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5;C9JVY5 Q9Y2D5-5;C9JVY5 AKAP2 A-kinase anchor protein 2 1 TNGHS(0.085)PS(0.915)QPR 89.35600000000002 0.035382 0.0 1167.4 745.0 1186.6 0.0 1846.8 655.47 3132.1 7004.0 1942.4 4012.9 True False 1102.5205814724688 802.1391044474382 1110.2554478723946 0.0 1614.7884733985213 745.7550427357656 3277.7488561384107 7024.3804804253805 2330.934275190592 3897.037150233656 0.28291251506451887 0.20583306587142594 0.28489732200931844 0.0 0.41436312027502814 0.1913646224006492 0.8410874030138218 1.802492562844626 0.5981298574612858 1.0 11.928161969364417 -7.3964750930980765 3.9507030295106382 1.176797172880662 0.23026348497086938 0.6604744786957588 0.29518794038546814 0.12810329837882137 3.447294552328422 0.12312277742225637 0.07938676327955957 4.013515152169039e-08 7.3964750930980765 -0.9465336879097928 TNIIPVLEDAR ddPTM_A459_Selumetinib_30min_R2 1 TNIIPVLEDAR 11 0 A6NHQ2 A6NHQ2 FBLL1 rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 147.62 0.0091865 1385000.0 10427.0 12607.0 11947.0 10801.0 11304.0 8007.7 9664.1 10377.0 9205.3 12590.0 False True 9847.509082588165 13573.916362105849 11178.343026910079 9329.885167235741 9883.890460957817 9110.687988336906 10113.499799050855 10407.195351995166 11046.617217572059 12226.493987251537 0.8054237864800883 1.1102051312714223 0.9142721567250304 0.7630875357207009 0.8083994047078146 0.7451594870808054 0.8271790596385289 0.8512003001716323 0.9034983560365117 1.0 13.577723142175511 -5.531503105881118 18.97946614931928 0.8309559925617518 0.9714202621238297 0.18483240090176212 0.09672352633833106 12.083219196869855 26590.569745658704 0.02493345095572244 0.043438064228487484 2.941012660856644e-06 5.531503105881118 0.14046426956207791 TNILQYASTRPPT(ph)LSPIPHIPR ddPTM_A459_Selumetinib_30min_R2 1 TNILQYASTRPPTLSPIPHIPR 22 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TNILQY(0.041)AS(0.049)T(0.049)RPPT(0.43)LS(0.43)PIPHIPR 60.332 0.021204 14816000.0 10265.0 9317.8 9965.9 11136.0 14054.0 8690.1 7707.2 9065.1 9478.5 10966.0 True False 9694.512394050787 10032.445298550785 9324.704844051497 9619.257589328507 12288.410875645883 9887.082394126473 8065.600071527076 9091.477940191904 11374.464851417848 10649.383086910275 0.9103355861023377 0.942068213404981 0.8756098609611471 0.9032689979151984 1.1539082381917714 0.9284183237129683 0.7573772119664787 0.8537093525508276 1.0680867387894806 1.0 13.378482237865931 TNILQYASTRPPTLS(ph)PIPHIPR ddPTM_A459_Selumetinib_30min_R1 2 TNILQYASTRPPTLSPIPHIPR 22 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TNILQYAS(0.001)T(0.001)RPPT(0.045)LS(0.953)PIPHIPR;TNILQY(0.001)AS(0.005)T(0.005)RPPT(0.039)LS(0.951)PIPHIPR 77.66 0.00065806 210790000.0 7066.7 10561.6 6871.3 6715.9 7107.5 6683.0 7436.0 7517.1 3489.6000000000004 6612.0 True False 7231.340360595449 9325.042962045367 5938.215201349169 5543.094138056462 6464.627879931047 6615.775087678501 6875.096533242055 7317.722089017977 5921.596329700035 7460.714606334014 0.9692557271197815 1.2498860302374482 0.7959311560192545 0.742970939184629 0.8664890993743002 0.8867481785272722 0.9215064368505961 0.980833938186747 0.7937036386129427 1.0 12.865098106783183 -5.271292844072309 24.9949189261099 0.8701106670171578 1.1095708848286017 0.4737034553374162 0.09947069239976576 496.8506344524083 1260344.0241057004 0.02576614170988135 0.054668853539104854 5.354354924670723e-06 5.271292844072309 0.2394602178114439 TNILQYASTRPPTLS(ph)PIPHIPR ddPTM_A459_Selumetinib_30min_R2 2 TNILQYASTRPPTLSPIPHIPR 22 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 1 TNILQY(0.028)AS(0.113)T(0.113)RPPT(0.092)LS(0.654)PIPHIPR;TNILQYAS(0.003)T(0.008)RPPT(0.053)LS(0.936)PIPHIPR 79.695 0.0005446 53522000.0 31214.0 26012.0 30870.0 34743.0 41303.0 31019.0 27018.0 33924.0 30642.0 31111.0 True False 29479.25083954227 28007.036758237264 28883.857808714678 30010.94346498204 36114.147886495084 35291.58568755353 28274.390535151357 34022.71322357947 36771.25620901467 30212.744593914427 0.9757223726532974 0.9269941256471799 0.9560156879799852 0.9933206621363014 1.195328275265973 1.168102605767968 0.935843165365602 1.126104684657893 1.2170776506157366 1.0 14.882869627242384 -6.073830720875526 5.957401612458785 1.10764714382743 0.9537964457557534 0.4356628988791966 0.0812563593062946 0.22038549091149642 13.79160017610333 0.024782483426824094 0.03249460135399074 8.436635365106432e-07 6.073830720875526 -0.15385069807167662 TNKPS(ph)TPTTATR ddPTM_A459_Selumetinib_30min_R2 1 TNKPSTPTTATR 12 1 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0;A0A2R8Y5N9;A0A2R8YFW8;A0A2R8YCL5;A0A2R8YEA0 A0A2R8Y7K2 SPAST Spastin 1 TNKPS(0.492)T(0.492)PT(0.012)T(0.004)ATR 115.09 0.025355000000000003 12035000.0 16225.0 12021.0 12211.0 13865.0 16348.0 12202.0 12047.0 13208.0 8553.1 10439.0 True False 15323.279453821135 12942.97204639283 11425.357554331556 11976.56308154093 14294.218087025683 13882.71474127239 12607.209370677636 13246.433093297892 10263.958993581477 10137.59894622072 1.511529459303934 1.2767295406983867 1.1270279693389242 1.1814003636438757 1.4100200809733694 1.3694282852299895 1.2436090081643625 1.3066637537714134 1.01246449460381 1.0 13.30742837522754 -8.263725266371264 21.821975956746375 1.006231909883879 1.2962480458574834 0.5618347198243936 0.10478976406760916 27.618093327816112 263596.6887710711 0.09066090281757512 0.02793328645767667 5.448472128633967e-09 8.263725266371264 0.2900161359736044 TNKPST(ph)PTTATR ddPTM_A459_Selumetinib_30min_R1 1 TNKPSTPTTATR 12 1 A0A2R8Y7K2;A0A2R8Y481;A0A2R8YGN6;A0A2R8Y4I8;A0A2U3TZR0;Q9UBP0-4;Q9UBP0-3;Q9UBP0-2;Q9UBP0;A0A2R8Y5N9;A0A2R8YFW8;A0A2R8YCL5;A0A2R8YEA0 A0A2R8Y7K2 SPAST Spastin 1 T(0.007)NKPS(0.004)T(0.979)PT(0.009)T(0.001)ATR 127.3 0.027077 7651500.0 2274.5 2660.8 2182.1 2417.2 2136.1 1988.4 1884.9 2328.0 1206.3 1738.1 True False 2327.491424593425 2349.27229902764 1885.782805417318 1995.0813964636282 1942.8901321590859 1968.3985013227502 1742.720475458303 2266.2538775902713 2047.002995333893 1961.202065527699 1.1867677816090658 1.1978736614248484 0.9615443704470666 1.0172747783267366 0.9906629032823877 1.0036694004771582 0.8885981236152689 1.1555432851231942 1.0437491532944656 1.0 10.937522470837951 -5.253401424923916 24.787028276446406 1.0085312329532448 1.1923207529708526 0.5770445999438139 0.06324427441738667 381.8783253729405 1177608.705325963 0.016544293890310414 0.04209696191514765 5.579542308265618e-06 5.253401424923916 0.18378952001760784 TNLQPLESTQS(ph)QDF ddPTM_A459_Selumetinib_30min_R1 2 TNLQPLESTQSQDF 14 0 Q9Y248 Q9Y248 GINS2 DNA replication complex GINS protein PSF2 1 TNLQPLEST(0.001)QS(0.999)QDF;TNLQPLESTQS(1)QDF 165.78 0.00024489 14826300.0 8811.1 10362.9 10514.5 10499.7 9533.1 9226.3 8989.5 9145.2 5223.200000000001 7257.200000000001 True False 9016.381486583916 9149.606850418497 9086.6886520143 8666.12449877923 8670.832788205507 9133.491798810137 8311.414777512024 8902.639588203845 8863.388912565682 8188.732311114218 1.1010717097622504 1.117341061204324 1.1096575522051593 1.058298668161013 1.0588736398718217 1.1153731068255386 1.0149818630939118 1.087181660111257 1.0823884058996265 1.0 12.999424411738904 -14.522878729066617 0.05676150142249263 0.7067726153061868 1.2141160319906923 0.4814942183265192 0.028138615198189325 400.9904138348453 1.6633878444902805 16.952642394623716 3.0929270786647036 3.0000001120004142e-15 14.522878729066617 0.5073434166845054 TNLQPLESTQS(ph)QDF ddPTM_A459_Selumetinib_30min_R2 2 TNLQPLESTQSQDF 14 0 Q9Y248 Q9Y248 GINS2 DNA replication complex GINS protein PSF2 1 TNLQPLESTQS(1)QDF;TNLQPLEST(0.002)QS(0.998)QDF 125.36 0.0013861 6838700.0 78630.0 69267.0 65808.0 74236.0 75007.0 65544.0 65906.0 68622.0 54203.0 69599.0 True False 74260.0593808293 74579.55617149101 61573.98492633288 64124.92873575701 65583.9500889122 74572.09105080784 68970.7595902615 68821.67865901637 65045.11455835853 67589.49603008086 1.0986923078665907 1.1034193262559497 0.9109993200560222 0.9487410396908132 0.9703275500045734 1.103308878314751 1.0204360683436062 1.018230386395944 0.9623553714531331 1.0 16.044511436666646 -5.224614965279403 24.199634636321246 0.9951514184238278 1.101055940079844 0.44371234310264984 0.048818005365375776 405.2480713780557 266311.8121163896 0.0135826205964949 0.03593311112704951 5.961904769868329e-06 5.224614965279403 0.10590452165601627 TNLS(ph)GRQSPSFK ddPTM_A459_Selumetinib_30min_R1 1 TNLSGRQSPSFK 12 1 Q6IN85-2;Q6IN85;Q6IN85-4 Q6IN85-2 SMEK1 Serine/threonine-protein phosphatase 4 regulatory subunit 3A 1 T(0.007)NLS(0.836)GRQS(0.157)PSFK 111.12 0.0329 22023000.0 1311.2 701.99 3493.2 3291.1 1783.5 1318.5 847.34 995.18 991.16 609.89 True False 1341.748408848933 619.8006844537025 3018.8426267741065 2716.371166598315 1622.1827399025003 1305.2370871022156 783.4244616026524 968.7845935997798 1681.9261285377931 688.1753223316773 1.9497188656850084 0.9006435777930721 4.386734788085188 3.947208041977878 2.3572230611324696 1.8966636040940963 1.138408245951412 1.4077584042353357 2.444037259050625 1.0 9.42663234835929 -6.747303746865522 3.127639769258585 1.5427098421425434 2.802097122924996 0.2604100078745384 0.9776643543748922 0.38828914373995754 7.852048269165316 0.38814489876540637 0.3642891711164109 1.789353936769319e-07 6.747303746865522 1.2593872807824524 TNLSGRQS(ph)PSFK ddPTM_A459_Selumetinib_30min_R1 1 TNLSGRQSPSFK 12 1 Q6IN85-2;Q6IN85;Q6IN85-4 Q6IN85-2 SMEK1 Serine/threonine-protein phosphatase 4 regulatory subunit 3A 1 TNLS(0.001)GRQS(0.998)PS(0.002)FK 121.45 0.017963 32853000.0 1837.3 734.71 5071.7 5247.7 2607.6 1594.1 1290.4 1262.4 1151.0 657.99 True False 1880.1055152365352 648.6898116425876 4382.990996853954 4331.287706529117 2371.743040409172 1578.0648013269931 1193.0640890930003 1228.9170511468903 1953.1629342860895 742.4494258653533 2.532301123467366 0.8737158236556177 5.903420279092289 5.833781474719082 3.1944843079982377 2.1254845735622974 1.6069297753209768 1.6552198821011146 2.630701656223389 1.0 9.536148945602953 -6.720626631201912 3.6463160954653913 1.8046364245905815 3.8029710629600455 0.3063164321518761 1.4229522309201739 0.32807773424088776 9.060600225400025 0.5549347135995836 0.5315716928276366 1.9027133652011716e-07 6.720626631201912 1.998334638369464 TNNDILS(ph)SCEIK ddPTM_A459_Selumetinib_30min_R2 1 TNNDILSSCEIK 12 0 E7EPP7;Q6ZWJ1;B5MCT9;Q6ZWJ1-2 E7EPP7 STXBP4 Syntaxin-binding protein 4 1 TNNDILS(0.616)S(0.384)CEIK 105.19 0.0094261 3382600.0 24385.0 18854.0 25389.0 23305.0 21149.0 14201.0 19026.0 19397.0 12381.0 23523.0 True False 23029.779320889276 20300.041174834892 23755.499381453086 20130.81879663261 18492.073545541112 16157.058846157117 19910.74669930379 19453.442058653796 14857.54595404382 22843.829869906123 1.0081400295853244 0.8886443862715703 1.0399087857307139 0.8812365926062353 0.8094997052093308 0.7072832768485119 0.8716028272270446 0.8515840894210678 0.6503964544761722 1.0 14.479516924782668 -6.015552281006081 3.9319205101976586 0.8064995964824119 0.970153551759978 0.36599912493750664 0.09555667126396783 0.22596064279817402 7.854490355577435 0.027146467241301663 0.0385794658809764 9.648231579888742e-07 6.015552281006081 0.1636539552775661 TNNDILSS(ph)CEIK ddPTM_A459_Selumetinib_30min_R2 1 TNNDILSSCEIK 12 0 E7EPP7;Q6ZWJ1;B5MCT9;Q6ZWJ1-2 E7EPP7 STXBP4 Syntaxin-binding protein 4 1 TNNDILS(0.134)S(0.866)CEIK 85.287 0.031466 2168700.0 23935.0 19252.0 24684.0 24768.0 23585.0 16989.0 14801.0 16619.0 14247.0 19018.0 True False 22604.78851939655 20728.566495063205 23095.858313907127 21394.55567281684 20622.041447424803 19329.080539212962 15489.275827625099 16667.35853857645 17096.798094440066 18468.900925301816 1.223937938203388 1.122349758596935 1.2505269483722512 1.1584097916463978 1.1165819520518003 1.046574488508557 0.8386679797716212 0.90245535486861 0.9257073912296528 1.0 14.172810394391961 -6.867785190736533 2.008512125288043 0.9090655004559497 1.184273876438109 0.8409321390175019 0.05284361596629513 0.11538189201836985 0.9533205572717816 0.021433527850648063 0.018281990772215335 1.3558598773391205e-07 6.867785190736533 0.2752083759821594 TNNNQILEVKS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 2 TNNNQILEVKSPIK 14 1 P42568-2;P42568;A0A0D9SF09;B1APT5 P42568-2 MLLT3 Protein AF-9 1 TNNNQILEVKS(1)PIK;TNNNQILEVKS(1)PIK 178.85 0.00034166 44175000.0 5241.2 5759.0 5583.200000000001 5880.5 4630.7 5221.7 4953.9 4611.1 2698.8 4600.3 True False 5363.309762400112 5084.733602713536 4825.032106322339 4853.581065656283 4211.854002616487 5169.174438924264 4580.223334592229 4488.798649036302 4579.666487446829 5190.793315716629 1.0332350829999606 0.9795677256726893 0.9295365492039835 0.93503647139266 0.81140853554386 0.9958351497589188 0.8823744379735323 0.8647615838305803 0.8822671620502714 1.0 12.34173932906164 -5.003615906534157 1.2748760840481455 0.9025112357791792 1.061682531768764 0.3448943768021159 0.05442856073488718 1.0189857322426705 1.9131936277953463 0.016061190580937457 0.1920017289871538 9.917086320986693e-06 5.003615906534157 0.15917129598958468 TNNNQILEVKS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 1 TNNNQILEVKSPIK 14 1 P42568-2;P42568;A0A0D9SF09;B1APT5 P42568-2 MLLT3 Protein AF-9 1 TNNNQILEVKS(1)PIK 159.4 0.0014173 6972100.0 29252.0 25417.0 24518.0 25146.0 24940.0 18765.0 17883.0 20353.0 11531.0 22651.0 True False 27626.290945033954 27366.402171463804 22940.538573179994 21721.07142073048 21806.814233571113 21349.708418290156 18714.59493449224 20412.223860379472 13837.522203059474 21997.00677563421 1.2559113713432695 1.2440966378106135 1.0428936449022201 0.987455777155582 0.9913537080747835 0.970573343730518 0.8507791594273703 0.9279546107604885 0.6290638696528071 1.0 14.425019603129353 -5.106512806370735 0.498074089796362 0.84303814248895 1.500066707493289 0.6825154430563455 0.09629430078632709 1.8877149705282674 0.45579640079030403 0.06296810037287094 0.6999995824193528 7.825051304042107e-06 5.106512806370735 0.6570285650043389 TNNNQILEVKS(ph)PIKQSK ddPTM_A459_Selumetinib_30min_R1 1 TNNNQILEVKSPIKQSK 17 2 P42568-2;P42568;A0A0D9SF09;B1APT5 P42568-2 MLLT3 Protein AF-9 1 T(0.007)NNNQILEVKS(0.971)PIKQS(0.023)K 71.65100000000002 0.033019 10692000.0 943.31 607.69 1858.3 1562.1 1222.5 907.3 659.48 882.32 665.03 651.42 True False 965.2872876382606 536.5413722925839 1605.953066911234 1289.3085592486484 1111.9250908499057 898.1733857624872 609.7348926496057 858.918007420726 1128.5073381305635 735.0361023681342 1.3132515321741407 0.7299524071864751 2.1848628410729565 1.7540751469142306 1.5127489483407865 1.2219445859444977 0.8295305369153517 1.168538531173462 1.5353087208842484 1.0 9.521671301530995 -6.828598215991285 4.615670117720933 1.1333703159094295 1.50914136535975 0.1758592562170146 0.3790506575299451 0.4052690604923191 16.698262053585687 0.14511595865284627 0.1295814379265543 1.483890259328202e-07 6.828598215991285 0.3757710494503206 TNNPQFDEVFYFEVTRPCS(ph)YSK ddPTM_A459_Selumetinib_30min_R1 1 TNNPQFDEVFYFEVTRPCSYSK 22 1 Q14644-2;Q14644 Q14644-2 RASA3 Ras GTPase-activating protein 3 1 TNNPQFDEVFY(0.002)FEVT(0.091)RPCS(0.717)Y(0.105)S(0.085)K 54.096 0.015513 8096400.0 746.88 794.34 504.01 705.28 601.85 608.37 595.85 706.17 521.51 741.28 True False 764.280850824505 701.3383035213526 435.5682103287582 582.1160877452702 547.4127737652476 602.2503501557643 550.9045547784131 687.4400776365649 884.9643804166282 836.4305086786563 0.9137410016665591 0.8384896249531663 0.5207464407495648 0.6959527201666316 0.6544629447221122 0.7200243701143373 0.6586375664951529 0.8218735095190899 1.0580249898041654 1.0 9.708101874749415 -8.09410444049595 3.408428748905726 1.0272576201664032 0.7097117523315717 0.599159979730423 0.10138791315610142 0.17884062533785675 3.746756757686168 0.08306729466579714 0.02822867855004845 8.051847845579438e-09 8.09410444049595 -0.3175458678348315 TNPPTQKPPS(ph)PPMSGR ddPTM_A459_Selumetinib_30min_R1 3 TNPPTQKPPSPPMSGR 16 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TNPPTQKPPS(1)PPMSGR;TNPPTQKPPS(0.5)PPMS(0.5)GR;TNPPT(0.001)QKPPS(0.886)PPMS(0.113)GR 283.22 3.7547999999999996e-62 192741000.0 6388.3 7892.0 8665.0 9391.3 7285.3 7283.5 7014.9400000000005 6402.4 4359.0599999999995 6611.9 True False 6537.134960532058 6968.000971108738 7488.340593438003 7751.285751534366 6626.345901324179 7210.234602888877 6485.797428039403 6232.587554073866 7397.006446854142 7460.601770359931 0.8762208682017187 0.9339730474278581 1.003718040974694 1.0389625381600298 0.8881784747779797 0.9664414245422223 0.8693397165100933 0.835400111936705 0.9914758453187456 1.0 12.865076287273947 TNPPTQKPPS(ph)PPMSGR ddPTM_A459_Selumetinib_30min_R2 2 TNPPTQKPPSPPMSGR 16 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TNPPTQKPPS(1)PPMSGR;TNPPTQKPPS(0.754)PPMS(0.246)GR 203.93 1.4353999999999996e-06 450093000.0 65244.0 55469.5 58949.3 58361.0 55019.0 39971.8 52375.8 49427.2 29471.6 49353.9 True False 61617.99967242568 59723.83228744587 55156.56621714494 50412.13112165958 48107.021343899316 45477.552622126874 54811.37848067877 49571.02496888656 35366.74350530635 47928.924670167915 1.2856119784965292 1.2460916387848646 1.1507991593117397 1.0518101849474055 1.0037158495617626 0.9488540152963867 1.143597083762546 1.0342611546163214 0.7378997911738971 1.0 15.548608951669497 -4.695368113281638 0.46493043797773537 0.9514285526702372 1.5974927994927695 0.6058452034630439 0.09403913104379472 3.852528486312835 0.6087006816672842 0.06722992956844702 1.4000511673987246 2.0166562966579807e-05 4.695368113281638 0.6460642468225323 TNPPTQKPPSPPMS(ph)GR ddPTM_A459_Selumetinib_30min_R2 1 TNPPTQKPPSPPMSGR 16 1 A0A0A0MRT6;Q8IZP0-2;Q8IZP0-4;Q8IZP0-3;Q8IZP0-5;Q8IZP0-6;Q8IZP0-9;Q8IZP0-12;Q8IZP0;B6VEX4;Q8IZP0-11;Q8IZP0-10;Q8IZP0-8;Q8IZP0-7 A0A0A0MRT6 ABI1 Abl interactor 1 1 TNPPTQKPPS(0.402)PPMS(0.598)GR 70.12100000000001 0.023874 495520000.0 67018.0 78038.0 75003.0 71629.0 68625.0 45896.0 61485.0 62654.0 34495.0 78987.0 True False 63293.40785431042 84023.26366828078 70177.38863709175 61873.006633082965 60003.71398471603 52217.75739759367 64344.174330216156 62836.312767071904 41394.96387082963 76706.44007712786 0.8251381212668621 1.0953873440586723 0.9148826169814269 0.806620755322109 0.7822513197637989 0.6807480225270398 0.8388366643728803 0.819179102874418 0.5396543475255434 1.0 16.22706008735976 -5.749061966289561 3.000631622823578 0.768294198536985 0.9689978053876368 0.2655586964065477 0.1259978293745061 0.2917542983981328 5.385213886702691 0.03459950807749866 0.061209145430032134 1.7821244710563025e-06 5.749061966289561 0.2007036068506518 TNPS(ph)PTNPFSSDLQK ddPTM_A459_Selumetinib_30min_R1 2 TNPSPTNPFSSDLQK 15 0 G3V3Z8;P49757-3;P49757;P49757-9;P49757-8;P49757-7;P49757-6;P49757-5;P49757-4;P49757-2 G3V3Z8 NUMB Protein numb homolog 1 T(0.001)NPS(0.934)PT(0.065)NPFSSDLQK;T(0.005)NPS(0.887)PT(0.109)NPFSSDLQK 199.91 2.0592e-05 72218000.0 8693.3 9904.2 11992.0 11526.8 9791.0 10131.1 9899.5 8891.5 5328.5 8543.0 True False 8895.836975782813 8744.611659662334 10363.55226734086 9513.860764834077 8905.405778741453 10029.190332302815 9152.772744866828 8655.66853633759 9042.075321757979 9639.577265866827 0.9228451342241372 0.907157172817784 1.0751044347180645 0.9869582972815722 0.9238377921690579 1.0404180656153446 0.9494993911482256 0.8979303031250966 0.9380157523894158 1.0 13.234754164539511 -9.865588117337365 6.575841430057332 0.999999999286837 0.9619471909632042 0.04397875239890925 0.055133349283179894 75783788.18563768 0.0 0.055523774320386236 0.013880943580096566 1.3627364821021578e-10 9.865588117337365 -0.03805280832363278 TNPS(ph)PTNPFSSDLQK ddPTM_A459_Selumetinib_30min_R2 3 TNPSPTNPFSSDLQK 15 0 G3V3Z8;P49757-3;P49757;P49757-9;P49757-8;P49757-7;P49757-6;P49757-5;P49757-4;P49757-2 G3V3Z8 NUMB Protein numb homolog 1 TNPS(0.997)PT(0.003)NPFSSDLQK;T(0.002)NPS(0.944)PT(0.053)NPFSSDLQK;TNPS(0.843)PT(0.157)NPFSSDLQK 289.95 3.5069e-67 41834400.0 83168.0 91977.0 103312.0 106167.0 110487.0 82944.0 94781.0 100532.0 76718.0 101529.0 True False 78545.85550788268 99031.34014733175 96665.01839760055 91706.87145170961 96606.63529368781 94368.78310933428 99188.50430498863 100824.53147603148 92063.74368002039 98597.59396597811 0.7966305499806167 1.0043991558404894 0.9803993638116117 0.9301126707346814 0.9798072286330101 0.9571104051676654 1.005993151711333 1.02258612427015 0.9337321528534227 1.0 16.589264821125212 -4.756502219338212 24.99871418974916 0.9787009331527204 0.7966302712365619 0.7766877351246997 0.029390647575942494 70.94756107566077 359193.11766122695 0.00734163660221183 0.05920016737304097 1.7518534818376045e-05 4.756502219338212 -0.1820706619161585 TNPSPT(ph)NPFSSDLQK ddPTM_A459_Selumetinib_30min_R2 1 TNPSPTNPFSSDLQK 15 0 G3V3Z8;P49757-3;P49757;P49757-9;P49757-8;P49757-7;P49757-6;P49757-5;P49757-4;P49757-2 G3V3Z8 NUMB Protein numb homolog 1 T(0.005)NPS(0.241)PT(0.755)NPFSSDLQK 155.88 0.00039317 7677800.0 22253.0 24839.0 25073.0 21219.0 27676.0 22768.0 21931.0 21061.0 17764.0 23634.0 True False 21016.267345817065 26744.071430026743 23459.8304774183 18328.935595183335 24199.093453420774 25904.085332674138 22950.83495545207 21122.284023163753 21317.296367630603 22951.625011493474 0.9156766605977903 1.16523651012223 1.0221424611839176 0.798589885727253 1.054352074909842 1.128638400100305 0.9999655773375083 0.9202957965976857 0.9287924648888936 1.0 14.486308681904331 -7.638393617943537 6.064176725922112 0.9441968751830588 1.0173151789877093 0.07683782329266786 0.09890097371829892 0.5483595159455422 26.891464788010463 0.04964502955946074 0.028192199626243582 2.2993568763466743e-08 7.638393617943537 0.07311830380465045 TNQELQEINR ddPTM_A459_Selumetinib_30min_R1 1 TNQELQEINR 10 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 143.4 0.015158 11289000.0 1325.4 1928.3 1598.2 1525.5 1639.6 1329.8 1312.5 1539.9 1042.4 1236.9 False True 1356.279241220542 1702.5337395576512 1381.1732182842038 1259.1000621815585 1491.2984694948902 1316.4234193617942 1213.4970683001873 1499.0568496998549 1768.876666116265 1395.6681634262761 0.9717777310983172 1.2198700122083745 0.9896143327461965 0.902148587448286 1.0685193719930157 0.9432209273370963 0.8694739194459588 1.0740782723163693 1.267404897861814 1.0 10.446740249212727 -7.999173094076469 24.991718212027873 1.146048845157718 0.9985999967633874 0.20905146299618216 0.10943040303929483 37.81903854406791 1143022.2106553637 0.06112771027400466 0.028975120154653256 1.0019058350522844e-08 7.999173094076469 -0.1474488483943306 TNQELQEINR ddPTM_A459_Selumetinib_30min_R2 1 TNQELQEINR 10 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33;H0YKS4;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 133.91 0.030342 55528000.0 80906.0 69846.0 77660.0 93438.0 88317.0 51462.0 67520.0 65631.0 55894.0 61759.0 False True 76409.56841237919 75202.96360971242 72663.44014981463 80711.5832104593 77221.82889600238 58550.42337447633 70659.8137883418 65821.97534420303 67074.36180884634 59975.85720084735 1.2740054411644102 1.2538872659689129 1.2115448372247364 1.345734550156942 1.2875485653735912 0.976233206278361 1.1781376221387878 1.0974745241869273 1.1183560342326997 1.0 15.87209425183596 -6.741577645327995 24.999155575115335 1.0866385174287079 1.273851651026761 0.7197345310864967 0.06231099368276376 136.57244432569107 171897.81427551166 0.02019926629164482 0.02017323427052425 1.8131024914088077e-07 6.741577645327995 0.18721313359805314 TNREDCFESES(ph)EDEFYK ddPTM_A459_Selumetinib_30min_R2 1 TNREDCFESESEDEFYK 17 1 Q96D09 Q96D09 GPRASP2 G-protein coupled receptor-associated sorting protein 2 1 TNREDCFES(0.395)ES(0.605)EDEFYK 73.796 0.013362 3525300.0 15993.0 14726.0 16571.0 15650.0 15134.0 10211.0 11476.0 14907.0 8294.6 13936.0 True False 15104.173085051556 15855.43684844695 15504.839901140616 13518.443002244174 13232.731620323377 11617.472563770885 12009.656739262591 14950.3769020133 9953.751770487992 13533.631469923552 1.1160473165401537 1.1715581943902684 1.1456525867131655 0.9988777241560677 0.9777665107647656 0.8584150225746106 0.8873935104522563 1.104683316908566 0.73548269676241 1.0 13.724261388167998 -5.935289340496059 2.0314513334782993 0.9254270415776885 1.1525353826495417 0.5275518433851514 0.09177128525060056 0.24802844433441046 2.0739400005483333 0.027847354891348867 0.046587677017578474 1.1606750783429424e-06 5.935289340496059 0.22710834107185318 TNS(ph)FNSHQPR ddPTM_A459_Selumetinib_30min_R1 1 TNSFNSHQPR 10 0 Q9NRM7 Q9NRM7 LATS2 Serine/threonine-protein kinase LATS2 1 T(0.032)NS(0.767)FNS(0.201)HQPR 102.97 0.014721 1867100.0 510.05 620.76 573.35 497.29 522.39 516.75 544.69 608.92 190.29 435.45 True False 521.9331726154655 548.0811306165056 495.49221918611414 410.44763678942456 475.1399167354452 511.5519641714598 503.60359476756514 592.7694635490848 322.9082317682882 491.3442491421877 1.0622555846062745 1.1154727700046796 1.008442085261338 0.8353565499260522 0.9670204089392868 1.0411274072395305 1.0249506240213055 1.2064239371560164 0.6571934694097608 1.0 8.940590359951324 -5.422586410754069 5.45274490218615 0.9727712315732963 1.0862602567868545 0.11781385032019576 0.13521540433057605 0.5099017681250652 22.227088311663884 0.034952415566989026 0.0741192334563465 3.7793193341638628e-06 5.422586410754069 0.11348902521355819 TNS(ph)FNSHQPRPGPPGK ddPTM_A459_Selumetinib_30min_R2 1 TNSFNSHQPRPGPPGK 16 1 Q9NRM7 Q9NRM7 LATS2 Serine/threonine-protein kinase LATS2 1 T(0.228)NS(0.771)FNS(0.001)HQPRPGPPGK 77.505 0.011845 2766300.0 10699.0 15245.0 9966.4 15549.0 13546.0 10744.0 11387.0 13235.0 9233.1 12954.0 True False 10104.392411490448 16414.24247959893 9325.172674595855 13431.199376478884 11844.230377223506 12223.888475678632 11916.518062912446 13273.511658827803 11079.977994368955 12579.984361465957 0.8032118420147999 1.3047903723853407 0.7412706094579902 1.0676642347521754 0.9415139190080271 0.9716934556072987 0.9472601650773279 1.0551294244439768 0.8807624617013272 1.0 13.618842508312794 -5.274561803027516 24.99876376378642 0.9571123045614103 1.054001160300426 0.07643641643284793 0.14227751165445315 1810.5015135525484 3449083.0736099496 0.03388268484072524 0.07130904564523587 5.314203694304866e-06 5.274561803027516 0.09688885573901573 TNS(ph)MGSATGPLPGTK ddPTM_A459_Selumetinib_30min_R1 3 TNSMGSATGPLPGTK 15 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.359)NS(0.626)MGS(0.016)ATGPLPGTK;T(0.015)NS(0.978)MGS(0.007)ATGPLPGTK;T(0.026)NS(0.967)MGS(0.006)AT(0.001)GPLPGTK 263.47 1.0833e-36 55965900.0 9527.599999999999 11222.7 11458.300000000001 11740.2 9799.900000000001 9573.3 11673.0 9010.7 6239.6 9176.5 True False 9749.574542517612 9908.741066708311 9902.325795936607 9689.994460848204 8913.500775312876 9477.00129386093 10792.496212013782 8771.706965121424 10588.145477646822 10354.393161679385 0.941588211909883 0.9569600952936199 0.9563405253515159 0.9358341246602402 0.8608424111517116 0.9152638059885926 1.0423108378727375 0.8471483386959527 1.0225751825642986 1.0 13.337955383780022 TNS(ph)MGSATGPLPGTK ddPTM_A459_Selumetinib_30min_R2 5 TNSMGSATGPLPGTK 15 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 TNS(0.918)MGS(0.082)ATGPLPGTK;T(0.2)NS(0.799)MGS(0.001)ATGPLPGTK;T(0.003)NS(0.909)MGS(0.076)AT(0.013)GPLPGTK;T(0.014)NS(0.985)MGS(0.001)ATGPLPGTK;T(0.009)NS(0.787)MGS(0.146)AT(0.058)GPLPGTK 193.41 3.1123e-05 120883000.0 316222.0 300698.0 344959.0 348680.0 338638.0 251455.0 278927.0 289668.0 217648.0 296793.0 True False 298647.6471769635 323760.5697035387 322764.71350296185 301189.1824934498 296095.26697786903 286090.64376877976 291897.65818336525 290510.8859228814 261183.6815932263 288223.8149291774 1.0361657562902895 1.1232956922143766 1.1198405433023355 1.044983678976903 1.0273102070022417 0.9925989073424699 1.0127464944390199 1.0079350521200547 0.906183556197133 1.0 18.13683001973697 -6.359437517310156 1.242165012520702 0.981602962654481 1.0958729164257583 0.6211955893244805 0.03660645600468115 0.30032264480124543 0.9534453618899645 0.015435550756243158 0.020290922805734076 4.3708155821851934e-07 6.359437517310156 0.11426995377127735 TNS(ph)PAYSDISDAGEDGEGKVDSVK ddPTM_A459_Selumetinib_30min_R2 1 TNSPAYSDISDAGEDGEGKVDSVK 24 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.223)NS(0.583)PAY(0.127)S(0.06)DIS(0.006)DAGEDGEGKVDSVK 76.762 0.00020676 10618000.0 36738.0 26860.0 39844.0 43306.0 31135.0 23373.0 25441.0 30256.0 20721.0 30719.0 True False 34696.24903386631 28920.075631487507 37280.480418867104 37407.64809298313 27223.54294956842 26592.418591030957 26624.056910385134 30344.039950849565 24865.778993113814 29832.06265245274 1.163052298397263 0.9694293005619492 1.2496782690888446 1.2539410542538378 0.9125598610704898 0.8914039535527918 0.8924645010490466 1.01716198119994 0.8335253007076061 1.0 14.864576111684071 -6.276600901183264 24.415308913991776 0.9221188407845006 1.1519578785236584 0.627375273789947 0.08845974815012723 405.72797377867056 653361.161732333 0.02809602204882173 0.03198593813729354 5.289310944885063e-07 6.276600901183264 0.22983903773915781 TNS(ph)PGFQK ddPTM_A459_Selumetinib_30min_R2 3 TNSPGFQK 8 0 A0A087X0H9;Q5T8P6-3;Q5T8P6-2;Q5T8P6;Q5T8P6-5;Q5T8P6-4 A0A087X0H9 RBM26 RNA-binding protein 26 1 T(0.001)NS(0.999)PGFQK;T(0.046)NS(0.954)PGFQK;T(0.024)NS(0.976)PGFQK 103.31 0.015517 48889100.0 275998.0 283262.0 281914.0 321595.0 304924.0 210017.0 246654.0 251264.0 183267.0 293756.0 True False 260659.13606753357 304987.2845691148 263775.9601647546 277793.2062176819 266616.72106485325 238944.9354054912 258123.89973562854 251995.13664100558 219925.5209078227 285274.5010102508 0.9137134063663379 1.0691011060892386 0.9246391080543027 0.9737751016439421 0.9345970990070117 0.8375965414339824 0.9048263999114079 0.88334266031001 0.7709259682481053 1.0 18.121991273196237 -6.553189966002684 4.310683196323967 0.8737957661362978 0.9726518659290165 0.29358374517555963 0.06637642368483013 0.23924005497452577 10.24583699814077 0.02117245067892345 0.02182442232027162 2.797757276863163e-07 6.553189966002684 0.0988560997927187 TNS(ph)SSSSPVVLK ddPTM_A459_Selumetinib_30min_R1 1 TNSSSSSPVVLK 12 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 T(0.135)NS(0.424)S(0.424)S(0.015)S(0.001)S(0.001)PVVLK 156.2 0.00043309 25092000.0 2347.1 3395.0 3067.6 3229.6 2465.9 2471.6 2616.4 2558.0 1526.5 2171.6 True False 2401.7828633384142 2997.5118217073195 2651.0367691206484 2665.6109871003364 2242.8597803900057 2446.737948033246 2419.0428415242764 2490.153530444982 2590.3590088511855 2450.3460131752786 0.9801811052089195 1.2233014462406462 1.081903027109753 1.0878508474997401 0.9153237005428462 0.9985275283071728 0.9872249994561225 1.0162456718584487 1.057140091612805 1.0 11.25876977113279 -6.092741481239096 7.9207698428646 0.9963191792006613 1.1042103526553708 0.35660375212236584 0.06389685846688685 0.30229521269806625 23.120779832223736 0.018307720138095087 0.02371859594467402 8.077156891841666e-07 6.092741481239096 0.10789117345470955 TNS(ph)TGGSSGSSVGGGSGK ddPTM_A459_Selumetinib_30min_R1 2 TNSTGGSSGSSVGGGSGK 18 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 TNS(0.357)T(0.357)GGS(0.254)S(0.023)GS(0.007)S(0.001)VGGGSGK;TNS(0.452)T(0.452)GGS(0.096)S(0.001)GSSVGGGSGK 193.71 2.4348e-10 167555000.0 10060.6 14262.2 13810.2 12140.199999999999 11878.3 13254.1 12603.8 14083.1 10395.7 11063.2 True False 10294.992405480152 12592.374993683108 11934.850693998558 10020.141969778148 10803.9098622842 13120.775787759938 11653.085218622402 13709.570439644138 17640.743628112872 12483.269484693661 0.8247032092116043 1.0087401388813424 0.956067695937547 0.8026857052204414 0.8654711712769956 1.0510688569086772 0.9334962473501683 1.0982355589178063 1.4131509096829993 1.0 13.60770821852556 -7.895318927149951 3.580860142510764 1.2206875038903613 0.9228786923413079 0.49516429715819843 0.11823793022290664 0.17839502934171422 4.344650922489956 0.0713705799160011 0.030779961203824212 1.2725682185437484e-08 7.895318927149951 -0.29780881154905336 TNS(ph)TGGSSGSSVGGGSGK ddPTM_A459_Selumetinib_30min_R2 2 TNSTGGSSGSSVGGGSGK 18 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 T(0.003)NS(0.485)T(0.485)GGS(0.022)S(0.003)GS(0.001)SVGGGSGK;T(0.012)NS(0.96)T(0.027)GGSSGSSVGGGSGK 205.36 3.2246e-11 38755840.0 21779.5 18081.8 15979.27 22684.4 22782.5 14144.4 29226.2 37181.9 20227.9 31450.2 True False 20569.082580246373 19468.615917849256 14951.181165113714 19594.745587227328 19920.358671865833 16092.66270992077 30585.276210616634 37290.09317320509 24274.04521474865 30542.151008566983 0.6734654207713401 0.6374343415559817 0.48952613589396343 0.6415640333168106 0.6522251385070499 0.5269001094718845 1.001411989680673 1.2209386680966028 0.7947719598380564 1.0 14.898514050725236 -7.27035515918885 23.272318221963978 1.0226923202903087 0.6038225077678565 0.7605296195682523 0.10997497548809416 114.99097314658891 300151.43982018303 0.04369393486101556 0.030012208975216993 5.3659279975007255e-08 7.27035515918885 -0.41886981252245215 TNSAEVT(ph)PPVLSVMGEATPVSIEPR ddPTM_A459_Selumetinib_30min_R1 2 TNSAEVTPPVLSVMGEATPVSIEPR 25 0 A0A0A0MSU2;A0A1C7CYX1;Q6PJG2 A0A0A0MSU2 ELMSAN1 ELM2 and SANT domain-containing protein 1 1 T(0.045)NS(0.045)AEVT(0.91)PPVLSVMGEATPVSIEPR;T(0.138)NS(0.049)AEVT(0.798)PPVLS(0.014)VMGEATPVSIEPR 110.31 2.1325e-05 0.0 697.6700000000001 510.92999999999995 794.63 875.45 859.6500000000001 713.41 708.06 552.381 504.18 253.231 True False 713.9243535704969 451.1100780750868 686.7236105901493 722.5690917317901 781.8948092835349 706.2337431244531 654.6504641376233 537.7300614936391 855.5566361497489 285.73566552882136 2.49854827275136 1.5787671351428987 2.4033527957358944 2.5288025924047854 2.7364270674312 2.4716331502313533 2.291105182568084 1.8819143927953224 2.994224170673056 1.0 8.158537314498968 -10.90426080806033 3.869908836811217 0.9945443168646249 2.3543037234318467 0.5394148158151382 0.38099179993892895 24675258.57896182 23230532.45558415 1021086.4357816685 0.09245902902008277 1.246634644471441e-11 10.90426080806033 1.3597594065672218 TNSGIS(ph)SASGGSTEPTTPDSERPAQALLR ddPTM_A459_Selumetinib_30min_R1 1 TNSGISSASGGSTEPTTPDSERPAQALLR 29 1 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4;A0A0J9YW54 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 T(0.303)NS(0.084)GIS(0.602)S(0.007)AS(0.001)GGS(0.001)T(0.001)EPT(0.001)TPDSERPAQALLR 92.424 6.224000000000001e-07 21293000.0 256.81 464.51 256.26 204.37 241.02 249.01 305.49 296.48 176.17 402.26 True False 262.79317333472744 410.12495325515965 221.46129953542098 168.6806160000296 219.2197835555371 246.5051854829903 282.44664334859016 288.61638729723535 298.94762305228545 453.89398934421075 0.578974781566094 0.9035699147453155 0.4879141489742788 0.37162998400516506 0.4829757359692456 0.5430897770625752 0.6222744737304653 0.6358673921067568 0.6586287328550156 1.0 8.826211573400354 -9.02003850282601 0.9052665622481972 1.0014331752276127 0.5672610661725278 0.49031224631775683 0.12995539067483244 1.6358900853282676 2.059414702332201 0.14306070563426143 0.04599233881751196 9.549079239199746e-10 9.02003850282601 -0.43417210905508485 TNSGIS(ph)SASGGSTEPTTPDSERPAQALLR ddPTM_A459_Selumetinib_30min_R2 1 TNSGISSASGGSTEPTTPDSERPAQALLR 29 1 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4;A0A0J9YW54 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 T(0.017)NS(0.053)GIS(0.546)S(0.124)AS(0.023)GGS(0.023)T(0.023)EPT(0.033)T(0.079)PDS(0.079)ERPAQALLR 73.435 6.3267e-05 22109000.0 8306.7 10286.0 9547.1 9037.8 10874.0 6351.6 9754.1 8809.0 7199.6 3560.6 True False 7845.04686835477 11074.903125297118 8932.84998009653 7806.836048925394 9507.910905206587 7226.47524591589 10207.68497738248 8834.63273159154 8639.72117363169 3457.796226450186 2.2687996500038365 3.202879059379026 2.58339398711968 2.2577490221105316 2.7497024933038112 2.0899077830664052 2.9520782339050116 2.5549894074184 2.4986206843372396 1.0 11.755637135784543 -9.022374557597015 2.334408241215743 1.0000194206596302 2.592318360720209 0.6912174311696656 0.31582028114018335 4.038388652622679 18.225061277664064 0.2938440149767303 0.07967833104144927 9.4978529728758e-10 9.022374557597015 1.5922989400605787 TNSGISSASGGSTEPT(ph)TPDSERPAQALLR ddPTM_A459_Selumetinib_30min_R1 1 TNSGISSASGGSTEPTTPDSERPAQALLR 29 1 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4;A0A0J9YW54 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 TNSGISSASGGSTEPT(0.473)T(0.473)PDS(0.054)ERPAQALLR 95.68 2.4929000000000003e-07 18768000.0 297.44 1000.8 787.04 695.18 1003.0 753.37 847.83 928.72 526.24 629.46 True False 304.36977328250947 883.6258707407025 680.1642909012631 573.7798631447893 912.2788270940331 745.79178180523 783.8775005081511 904.0873286922842 892.9908449510965 710.2573224596204 0.42853450947675875 1.244092588416698 0.9576308042074877 0.8078478672459021 1.2844342441058016 1.050030401971153 1.1036528251389006 1.272901102323635 1.2572779142334924 1.0 9.472197989856173 -4.754292980727562 24.99977366767674 1.1065656489744695 0.4285333314893943 0.6472054980704125 0.15063451058196076 165.4661194260747 578789.4881369623 0.03885626502406266 0.3841271511468264 1.7607877952166302e-05 4.754292980727562 -0.6780323174850752 TNSGISSASGGSTEPTT(ph)PDSERPAQALLR ddPTM_A459_Selumetinib_30min_R2 1 TNSGISSASGGSTEPTTPDSERPAQALLR 29 1 A2A2F0;Q86X10-2;Q86X10-3;Q86X10;Q86X10-4;A0A0J9YW54 A2A2F0 RALGAPB Ral GTPase-activating protein subunit beta 1 TNSGISSASGGSTEPT(0.254)T(0.742)PDS(0.003)ERPAQALLR 105.44 2.4074000000000004e-10 21633000.0 4938.0 4518.6 5399.6 4603.5 4616.6 3709.8 4592.8 3883.1 1722.3 3621.0 True False 4663.565728380205 4865.162090410999 5052.195614639965 3976.4953585195562 4036.6214350723517 4220.791275788585 4806.374300460551 3894.3991781181894 2066.808125082763 3516.452321512141 1.3262132689388444 1.3835427429651277 1.4367308732533661 1.1308258992146913 1.1479244039164245 1.2002981669814208 1.366824816892077 1.1074795908063169 0.5877537745752789 1.0 11.779904941045311 -8.047463233480983 5.256083429548059 0.8000369000749582 1.278054481829864 0.6808590695083034 0.1330435707484257 0.11916624479260896 7.593366008912653 0.09259258138662171 0.035028289703141244 8.964720763051897e-09 8.047463233480983 0.47801758175490583 TNSMGS(ph)ATGPLPGTK ddPTM_A459_Selumetinib_30min_R1 2 TNSMGSATGPLPGTK 15 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 TNS(0.002)MGS(0.968)AT(0.026)GPLPGT(0.004)K;T(0.008)NS(0.26)MGS(0.731)AT(0.001)GPLPGTK 238.05 5.7499e-20 73472000.0 11207.1 12862.599999999999 14018.699999999999 13806.699999999999 12005.5 12636.8 12780.5 11691.9 7396.6 10314.3 True False 11468.203624779493 11356.64081233949 12115.037539207076 11395.619028857513 10919.604644743175 12509.685265296375 11816.456595360423 11381.792831356399 12551.489973710244 11638.240874789912 0.9853897808234281 0.9758038980735991 1.0409681041616843 0.9791530482533702 0.9382521604615174 1.0748776726553355 1.0153129431232646 0.9779650510594762 1.0784696853025753 1.0 13.506585390286354 -6.761704321438855 24.999999977254475 1.0270721204153266 0.9863681189761193 0.2717014827869464 0.03697389917321201 11.440724746530003 1079450.374620165 0.012673210826225776 0.011884314518552158 1.7309944625151403e-07 6.761704321438855 -0.04070400143920727 TNSMGS(ph)ATGPLPGTK ddPTM_A459_Selumetinib_30min_R2 1 TNSMGSATGPLPGTK 15 0 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.001)NS(0.023)MGS(0.975)AT(0.001)GPLPGTK 236.75 6.6548e-20 22450000.0 75119.0 87590.0 75398.0 87746.0 89324.0 67030.0 77913.0 78780.0 47657.0 71658.0 True False 70944.18670518283 94307.87135375987 70546.9747671353 75794.84342970731 78102.3205533082 76262.77406224296 81536.10888168059 79009.23675726895 57189.73164783673 69589.04735015669 1.0194734574854485 1.3552114153714956 1.0137654911721743 1.0891777702937135 1.122336395270862 1.0959019697238497 1.1716801994918673 1.1353688513612201 0.8218208730473152 1.0 16.086572637102798 -8.247461863507032 24.717840057796003 0.9109104449134955 1.1285606736244203 0.4313878285520535 0.09842988000055104 515.423655802027 911479.9903005359 0.06362782679606253 0.023776053086907837 5.656374249562e-09 8.247461863507032 0.21765022871092476 TNSMSSSGLGS(ph)PNR ddPTM_A459_Selumetinib_30min_R1 4 TNSMSSSGLGSPNR 14 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 TNSMSSSGLGS(1)PNR;TNSMSSSGLGS(1)PNR;TNSMSSSGLGS(1)PNR;TNSMSSSGLGS(1)PNR 244.0 5.900000000000001e-20 319856000.0 7600.8 8982.5 10031.5 10398.600000000002 8874.4 7507.2 8701.7 7939.7 4677.12 7016.3 True False 7777.883851417764 7930.824724149042 8669.277399085206 8582.67971589719 8071.712086902572 7431.684383992224 8045.323763221134 7729.113364219711 7936.731036670854 7916.910449549508 0.9824392862572224 1.0017575384600095 1.0950328987968418 1.08409458090884 1.0195532889173797 0.938710173791988 1.016220129618737 0.9762789933615477 1.002503576015878 1.0 12.950721817401282 -6.528895647297533 24.93736386344552 0.986216727174548 1.0431507041021535 0.3269530401481374 0.0367130889109885 185.63087330887623 769350.1657096655 0.012863551908985789 0.012900404200346997 2.9587233060745105e-07 6.528895647297533 0.05693397692760549 TNSMSSSGLGS(ph)PNR ddPTM_A459_Selumetinib_30min_R2 4 TNSMSSSGLGSPNR 14 0 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 TNSMS(0.001)S(0.001)S(0.001)GLGS(0.997)PNR;TNSMSSSGLGS(1)PNR;TNSMSSSGLGS(1)PNR;TNSMSSSGLGS(1)PNR 169.15 0.00018309 326553000.0 59856.6 54513.4 59610.6 73482.9 77519.0 47111.100000000006 46196.2 62411.0 46299.6 65510.1 True False 56530.009796954764 58694.40249179194 55775.31889511395 63474.40225492703 67780.37019134715 53600.22639301411 48344.41483603371 62592.60567730277 55560.81371891183 63618.65319731907 0.8885760222182285 0.922597375800237 0.8767132922811444 0.9977325684348483 1.06541661580166 0.8425237520632213 0.7599094354620977 0.9838719075546298 0.8733415582782754 1.0 15.957162209991548 TNSMSSSGLGSPNRS(ph)SPSIICMPK ddPTM_A459_Selumetinib_30min_R2 1 TNSMSSSGLGSPNRSSPSIICMPK 24 1 F8VVY1;F8VX63;F8VP97;Q9NZN8-4;Q9NZN8-5;Q9NZN8;F8VQD8;A0A087X050;F8VUB4;F8VV52 F8VVY1 CNOT2 CCR4-NOT transcription complex subunit 2 1 T(0.002)NS(0.002)MS(0.008)S(0.008)S(0.008)GLGS(0.008)PNRS(0.365)S(0.365)PS(0.235)IICMPK 49.287 0.025369 4545600.0 13584.0 12282.0 13115.0 18363.0 15003.0 10677.0 5395.5 6726.4 5924.1 13002.0 True False 12829.055661060487 13223.989907145551 12271.195178532327 15861.927722058135 13118.189011478249 12147.659833844067 5646.401440980421 6745.9727103845335 7109.085533183992 12626.598476746987 1.016034182498663 1.0473121428149246 0.9718528074786597 1.2562312606415178 1.038932934759632 0.9620690684205307 0.4471830993421368 0.5342668275076495 0.5630245981351201 1.0 13.624178418383963 -7.117812718075589 4.644692708123389 0.5994969317586456 1.0647807779280087 0.6313286661892602 0.15481141168163265 0.13375771042090026 4.5065591639530025 0.058383396514055684 0.04498796511415881 7.62407714182293e-08 7.117812718075589 0.46528384616936314 TNSPAY(ph)SDISDAGEDGEGKVDSVK ddPTM_A459_Selumetinib_30min_R1 1 TNSPAYSDISDAGEDGEGKVDSVK 24 1 O15014 O15014 ZNF609 Zinc finger protein 609 1 T(0.111)NS(0.092)PAY(0.576)S(0.213)DIS(0.009)DAGEDGEGKVDSVK 108.55 4.2399e-06 3927400.0 915.97 1118.2 1526.1 1255.5 1064.5 980.19 906.27 1145.5 610.52 970.0 True False 937.3103188326397 987.2806241629232 1318.8640022672525 1036.2504936538487 968.21616295274 970.330178541312 837.9093242578375 1115.1176188916054 1036.0078493834437 1094.5089486001202 0.8563751991534304 0.9020306553232458 1.2049823840673783 0.946772061552549 0.8846123772593097 0.886543851269893 0.7655573079868608 1.0188291473704658 0.946550369193875 1.0 10.09606803456536 -5.995414243512604 24.99975780251947 0.9094815249233771 0.9953291168490543 0.07641015906045001 0.10740143122940131 309.61844682740997 1687887.2910763358 0.03145916076286699 0.04646802404913547 1.010615038499113e-06 5.995414243512604 0.08584759192567726 TNSS(ph)SSSPVVLK ddPTM_A459_Selumetinib_30min_R1 1 TNSSSSSPVVLK 12 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 T(0.015)NS(0.341)S(0.617)S(0.021)S(0.002)S(0.003)PVVLK 102.5 0.011551 23142000.0 2741.7 3076.4 3836.3 4339.0 2627.2 3302.2 3306.2 3037.1 2077.6 3278.6 True False 2805.5762755804753 2716.2136578204418 3315.3515312875047 3581.2751031175244 2389.570223869832 3268.9828661577076 3056.8106721631098 2956.5462421088573 3525.535458099721 3699.440246268407 0.7583785894123943 0.7342228761662694 0.8961765322825989 0.9680586425824623 0.6459275092441811 0.883642564427173 0.826290051649432 0.799187456829746 0.9529915942434528 1.0 11.85309128107282 -8.371501573197294 3.7307381274465308 0.9972748543934591 0.8162111740420703 0.3681527806567242 0.08589733876622427 0.25403483804131133 5.9751208553572965 0.08256792114899686 0.02197292089273309 4.251071668848517e-09 8.371501573197294 -0.18106368035138876 TNSS(ph)SSSPVVLK ddPTM_A459_Selumetinib_30min_R2 1 TNSSSSSPVVLK 12 0 Q7Z589;Q7Z589-5;Q7Z589-7;E9PMC9;Q7Z589-6;Q7Z589-4;Q7Z589-2 Q7Z589 EMSY;C11orf30 Protein EMSY 1 T(0.213)NS(0.253)S(0.476)S(0.051)S(0.006)S(0.002)PVVLK 83.869 0.033612 15413000.0 56241.0 52764.0 58389.0 62267.0 53336.0 43733.0 51572.0 49277.0 31579.0 51298.0 True False 53115.350370561144 56810.82913699949 54632.315309136444 53786.12718343373 46635.4548501102 49756.8237813527 53970.2001879793 49420.387911753496 37895.682390982154 49816.8934517895 1.066211613977169 1.1403928507099383 1.0966624276161878 1.07967646026514 0.9361373545952208 0.9987941907599089 1.0833714518993276 0.9920407413517319 0.760699428752133 1.0 15.604347438433784 -6.537788565825069 0.5413969693931546 0.9261125510300839 1.1268037975040308 0.3885117367003924 0.08042349386825771 1.1307018430151958 0.706322539084062 0.06917996791322537 0.10706117295751924 2.8987544888772516e-07 6.537788565825069 0.20069124647394687 TNSSDS(ph)ERS(ph)PDLGHSTQIPR ddPTM_A459_Selumetinib_30min_R2 1 TNSSDSERSPDLGHSTQIPR 20 1 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 2 T(0.036)NS(0.132)S(0.064)DS(0.751)ERS(0.95)PDLGHS(0.027)T(0.04)QIPR 83.891 0.0053885 18755000.0 76025.0 68614.0 101440.0 84614.0 106160.0 60503.0 74670.0 66232.0 56986.0 88057.0 True False 71799.83485218808 73876.4731712167 94913.46083952123 73089.42723270868 92823.23171755843 68836.73905844979 78142.30295579806 66424.72415470211 68384.79232187566 85514.56561043752 0.8396211141301116 0.8639051446248552 1.1099098751422123 0.8547014968849671 1.0854669149629503 0.8049709259126248 0.913789392461819 0.7767650303844216 0.7996858995156835 1.0 16.383882553281552 -6.815848729531042 24.999991939140426 0.848511723669738 0.9494099764260301 0.1576740330107469 0.10451962343374192 159.61463988479747 73338.32204453858 0.035779511681452374 0.031554586431284316 1.528098222222733e-07 6.815848729531042 0.10089825275629205 TNST(ph)GGSSGSSVGGGSGK ddPTM_A459_Selumetinib_30min_R1 3 TNSTGGSSGSSVGGGSGK 18 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 TNS(0.087)T(0.716)GGS(0.161)S(0.019)GS(0.015)S(0.001)VGGGSGK;TNS(0.013)T(0.976)GGS(0.01)S(0.001)GSSVGGGSGK;T(0.002)NS(0.111)T(0.885)GGS(0.002)SGSSVGGGSGK 261.94 2.2478e-42 164899300.0 5966.59 7576.1 7278.530000000001 6165.26 6556.7 7038.799999999999 6061.0 6552.0599999999995 5169.56 5898.1 True False 6105.599938036879 6689.086689966664 6290.145604103443 5088.613077263508 5963.647642679406 6967.996062719056 5603.8138902609035 6378.278084709671 8772.365750276285 6655.178587359143 0.9174209013164373 1.0050949951473769 0.9451505352615113 0.7646095458548366 0.8960913015928329 1.0470036184985447 0.8420230677062215 0.9583932273169322 1.3181262734163934 1.0 12.700261665095343 -8.09618343092357 7.4511938119308105 1.1567199415781997 0.9182725795526959 0.4643064001374517 0.10267435142976633 0.23352809983822087 15.835767170393822 0.06789555660511706 0.025445657896305016 8.013395338803425e-09 8.09618343092357 -0.23844736202550376 TNST(ph)GGSSGSSVGGGSGK ddPTM_A459_Selumetinib_30min_R2 4 TNSTGGSSGSSVGGGSGK 18 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 TNS(0.099)T(0.9)GGSSGSSVGGGSGK;TNS(0.088)T(0.888)GGS(0.023)SGSSVGGGSGK;TNS(0.058)T(0.92)GGS(0.01)S(0.01)GS(0.001)S(0.002)VGGGSGK;T(0.001)NS(0.279)T(0.72)GGSSGSSVGGGSGK 255.69 1.6635e-33 167404840.0 64521.6 44492.1 52025.5 63012.0 57911.2 44566.59 82212.0 117067.8 58326.3 90209.5 True False 60935.74777242937 47904.50100535018 48678.235971081485 54429.656898237045 50635.87732330328 50705.23323727609 86035.02089998759 117408.44791638246 69993.18977298644 87604.91734257097 0.6955745136331302 0.5468243388441774 0.5556564339959333 0.6213082387304228 0.578002683631289 0.5787943733683114 0.9820798136656593 1.3402038547364588 0.7989641665807926 1.0 16.418724231415112 -7.314624778089348 4.52360449667032 1.0688170987951393 0.5912713193412575 0.7278210464243855 0.12997435087474835 0.10180549829509228 4.495044793906678 0.052485115266117294 0.035264802878484026 4.845908637694911e-08 7.314624778089348 -0.47754577945388177 TNT(ph)PQGVLPSSQLK ddPTM_A459_Selumetinib_30min_R1 1 TNTPQGVLPSSQLK 14 0 A0A2R8Y4Z0;Q14004-2;Q14004;A0A2R8Y7W5;A0A2R8YF61 A0A2R8Y4Z0 CDK13 Cyclin-dependent kinase 13 1 T(0.288)NT(0.711)PQGVLPSSQLK 144.41 0.0012396 14143000.0 4607.9 4294.8 5040.9 5666.5 3070.0 4122.4 3142.4 3778.1 2753.1 4527.5 True False 4715.2551045874 3791.962819401648 4356.3734676816675 4676.952148378765 2792.319042052523 4080.93239883972 2905.3662380392457 3677.892515001635 4671.809621531744 5108.648726584578 0.92299458368511 0.7422633698944477 0.852744766930599 0.9154969148770526 0.5465866203565237 0.7988281475692801 0.5687152109167717 0.7199345094647983 0.9144902833542665 1.0 12.318726023328399 -1.5228858285912956 0.7278396241138242 0.756708517946091 22.71428994840155 0.045873816134087475 0.14214998551657307 913.5285623044423 4.328878542850396 0.05359034803108231 32787.61921478518 0.02999951070620355 1.5228858285912956 21.95758143045546 TNT(ph)PVKEDWNVR ddPTM_A459_Selumetinib_30min_R1 1 TNTPVKEDWNVR 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 T(0.19)NT(0.81)PVKEDWNVR 90.476 0.033717000000000004 75777000.0 4532.4 6680.4 7318.0 8024.2 4644.2 6419.3 5728.7 5432.6 4099.2 6355.9 True False 4637.996101484827 5898.2556623663 6324.255794896633 6622.924102889058 4224.132930000106 6354.7276702580575 5296.57954679717 5288.509800428227 6956.043006277621 7171.741676708761 0.6467042889382605 0.8224300216391947 0.881829837155951 0.9234749941423483 0.5889968044608427 0.8860787179348538 0.7385346245806031 0.7374094102696708 0.9699238092844795 1.0 12.808107808500965 -8.309854504630202 6.7170300018305795 0.9892490050085346 0.7839782261202143 0.399560233736706 0.10121879541216136 0.2685103206956032 29.41108991948162 0.09430968373196158 0.02499716821237699 4.89942930337937e-09 8.309854504630202 -0.20527077888832035 TNTEEKNT(ph)LPSK ddPTM_A459_Selumetinib_30min_R1 1 TNTEEKNTLPSK 12 1 H3BU88;A0A087X1C1;P0CG35;P0CG34 H3BU88 TMSB15B;TMSB15A Thymosin beta-15B;Thymosin beta-15A 1 TNTEEKNT(0.808)LPS(0.192)K 97.163 0.022778 15367000.0 857.05 963.41 1753.2 1720.4 1412.1 981.26 922.78 926.02 628.11 660.85 True False 877.0175974710019 850.6135093228421 1515.1250696382583 1419.9644359076726 1284.3758043265032 971.389415312795 853.1739616655595 901.4589414631208 1065.8567946606745 745.6765347241128 1.1761367786576293 1.140727205044147 2.0318797750539757 1.9042632693719328 1.7224302288145619 1.302695431702423 1.144160935654518 1.2089141866273756 1.4293822388484074 1.0 9.542406132653571 -6.8816026248499105 5.2389576168409535 1.2148595340280302 1.6099435753071307 0.31615379902673435 0.28003993523698356 0.29603180961258685 12.390434328818982 0.11117375329248326 0.09801826525596581 1.3134010983909488e-07 6.8816026248499105 0.3950840412791006 TNTMNGS(ph)KSPVISR ddPTM_A459_Selumetinib_30min_R1 1 TNTMNGSKSPVISR 14 1 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 T(0.047)NT(0.01)MNGS(0.471)KS(0.471)PVISR 208.38 2.8627e-05 72654000.0 3240.3 3410.0 3343.9 3702.6 2990.4 3153.0 3246.2 2833.7 1849.7 2561.3 True False 3315.7926854737607 3010.7556147340088 2889.8167467279113 3056.0104164099903 2719.9188479979994 3121.283682694947 3001.336520469384 2758.54107084517 3138.8058032571525 2890.06780417473 1.1473061914616907 1.0417595083357367 0.9999131309492268 1.057418241881922 0.9411263099326082 1.0800036172806131 1.03850038263252 0.954490087346889 1.0860664925311156 1.0 11.496887625000198 -4.7721562746607304 3.4411025856021147 1.0193892197583885 1.1648389975837157 0.4082101887921934 0.04587079087695151 0.2928042387799479 5.560228943994952 0.01090395014607826 0.11416985578141652 1.6898327600676858e-05 4.7721562746607304 0.1454497778253272 TNTMNGSKS(ph)PVISR ddPTM_A459_Selumetinib_30min_R1 1 TNTMNGSKSPVISR 14 1 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 TNT(0.002)MNGS(0.091)KS(0.906)PVISR 218.34 5.0373e-08 71216000.0 4226.0 4319.1 4463.7 4556.8 4525.7 3322.2 4339.2 3583.1 2085.4 2851.5 True False 4324.457577635441 3813.4177641048855 3857.554057349014 3761.040421729876 4116.35123407723 3288.7816843162527 4011.8906504900397 3488.0645484509046 3538.7714884102625 3217.5178009621045 1.3440353232365456 1.18520486909648 1.1989223668616613 1.1689260648706425 1.2793561648194631 1.0221487145565562 1.2468899625948926 1.0840855479984917 1.0998451935066518 1.0 11.651732414860577 -1.5228787452829586 0.07715739691954016 0.8386449020989283 1.9944191590501263 0.525707976626508 0.07281648256512965 168.07424610848267 0.9526545563800363 2.246366057562867 20.800430870139554 0.029999999999818942 1.5228787452829586 1.1557742569511982 TNTMNGSKS(ph)PVISR ddPTM_A459_Selumetinib_30min_R2 1 TNTMNGSKSPVISR 14 1 A0A0U1RRM6;Q8N8S7-3;Q8N8S7-2;Q8N8S7 A0A0U1RRM6 ENAH Protein enabled homolog 1 TNTMNGS(0.095)KS(0.904)PVISR 102.72 0.035091000000000004 13615000.0 41080.0 31770.0 32164.0 45453.0 39519.0 29724.0 30842.0 32228.0 26931.0 32429.0 True False 38796.93805626947 34206.656843349134 30094.603257515366 39262.222989201546 34554.269915657445 33818.21119239311 32276.21411226358 32321.778144367374 32317.952515011224 31492.690509339198 1.2319346943305522 1.0861776586921053 0.9556059762055189 1.2467090729373624 1.0972155556353729 1.0738431885444744 1.0248795384024756 1.0263263513411884 1.0262048746018475 1.0 14.942729395792828 -7.019314755758121 2.233017411318033 1.0205625059382393 1.1191118003487532 0.2955088369745902 0.07593064658353593 0.4633642842888319 4.618857017948696 0.03356667143992726 0.02606012204566587 9.565005943868461e-08 7.019314755758121 0.09854929441051397 TNYNDRYDEIR ddPTM_A459_Selumetinib_30min_R1 3 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 ;; 125.72 0.0092875 71253000.0 13496.1 17208.9 15711.6 15798.7 15800.800000000001 15104.900000000001 15817.599999999999 14307.400000000001 8220.2 13826.7 False True 13810.532871160838 15194.073987799438 13578.051017641154 13039.753623328614 14371.62042985781 14952.95842015189 14624.465697177171 13927.92127501506 13949.079020346235 15601.49162846317 0.8852059277437979 0.9738859815224049 0.8703046696425824 0.8358017254926475 0.9211696401925058 0.9584313331215008 0.9373761205304546 0.892730105985836 0.8940862420422484 1.0 13.92939634851587 -6.504704777056703 24.742881758725588 0.9309765938176157 0.8935473084328296 0.18950378839884563 0.04333738890647363 1417.2305040859676 1929485.7541330233 0.014165329307963615 0.01574463922088999 3.1282051231273893e-07 6.504704777056703 -0.03742928538478607 TNYNDRYDEIR ddPTM_A459_Selumetinib_30min_R2 3 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 ;; 115.29 0.017531 59842000.0 315691.0 280124.0 330806.0 337344.0 369114.0 257144.0 276648.0 246948.0 222506.0 342209.0 False True 298146.1580312017 301608.6100593753 309522.30211433925 291397.16524914093 322742.5993989719 292563.25187917915 289512.6801676124 247666.57779555806 267013.4173370868 332328.5370042393 0.8971428115046239 0.9075615737914433 0.931374431171377 0.8768346163586421 0.9711552378508346 0.8803434532480343 0.871164067875156 0.7452461953106325 0.8034621996174849 1.0 18.342250656804126 -7.29142538308748 2.8478797253453867 0.8295600955676223 0.914448461988135 0.12578124106799604 0.06597961528410862 0.38147118880061287 6.185374838724551 0.028873903006039366 0.01911681344937008 5.111808983983733e-08 7.29142538308748 0.08488836642051267 TPAAAAAMNLAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 TPAAAAAMNLASPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 TPAAAAAMNLAS(1)PR;TPAAAAAMNLAS(1)PR;TPAAAAAMNLAS(1)PR;TPAAAAAMNLAS(1)PR 171.15 0.00014624 162540000.0 2983.3199999999997 3560.67 3787.7 3786.85 3511.6000000000004 3212.29 3698.7999999999997 3003.8700000000003 1660.64 2813.1800000000003 True False 3052.825551469798 3143.7851010894265 3273.3511443468137 3125.5477354783584 3193.976400023334 3179.9772791259566 3419.796538079034 2924.1976096551084 2817.9847916532167 3174.279055693696 0.961738239741069 0.9903934234926282 1.0312108944786729 0.9846480667388305 1.0062052970088773 1.0017951236587217 1.077345903771426 0.9212163008825525 0.8877558469847208 1.0 11.632213247922977 -7.8006480460564305 24.99990127581027 0.9283643912159292 1.0067024964642945 0.40772272761731043 0.0390147056752094 145.16769235678086 92558.76516832666 0.020680530041597648 0.009934819413510366 1.5825300082405838e-08 7.8006480460564305 0.07833810524836538 TPAAAAAMNLAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 TPAAAAAMNLASPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 TPAAAAAMNLAS(1)PR;TPAAAAAMNLAS(1)PR;TPAAAAAMNLAS(1)PR;TPAAAAAMNLAS(1)PR 159.64 0.00029672 146804000.0 103292.0 100196.0 102628.0 134442.0 115289.0 90585.1 82931.3 95290.0 81892.0 94947.0 True False 97551.44415063753 107880.71101908144 96025.02621291767 116130.76767461393 100805.36512326304 103062.37527533458 86787.76977525341 95567.27812389133 98272.68825365943 92205.63340806788 1.0579770513468638 1.170001300697556 1.0414225537386266 1.2594758409246245 1.0932668796616356 1.1177448867925324 0.94124151168902 1.0364581272485387 1.0657991775702145 1.0 16.492567275991533 -7.143986876414488 7.414533580764412 1.01416554545114 1.1273826309175883 0.4226667122981278 0.06429821858322585 0.2601136691541225 14.931880225968564 0.023863333239437946 0.018468331930115368 7.178159820307056e-08 7.143986876414488 0.11321708546644826 TPAALAALSLTGSGT(ph)PPTAANYPSSSR ddPTM_A459_Selumetinib_30min_R2 2 TPAALAALSLTGSGTPPTAANYPSSSR 27 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 TPAALAALS(0.004)LT(0.019)GS(0.047)GT(0.927)PPT(0.002)AANYPSSSR;TPAALAALSLTGS(0.045)GT(0.955)PPTAANYPSSSR 148.66 1.1284000000000001e-13 6940600.0 23340.5 23019.0 24828.9 31922.0 30910.0 23601.6 28083.2 25690.2 21982.5 23912.3 True False 22043.3284494245 24784.483282249115 23231.435605662336 27574.16853147851 27026.809461093962 26852.506166006762 29389.124445805086 25764.95422875843 26379.61424236882 23221.889767383233 0.9492478291058766 1.0672896792861646 1.0004110706912628 1.1874213859290796 1.1638505621990767 1.156344571221029 1.265578501155585 1.1095115206750792 1.1359805126377283 1.0 14.503197761188565 -5.756668519715884 24.99412437127164 1.1563061010037685 1.0118135054765562 0.46012012892342 0.06864553567407165 98.36777872864936 515332.49282073614 0.017998881896693922 0.029933586028768267 1.7511827891716548e-06 5.756668519715884 -0.14449259552721228 TPAAPAS(ph)PAAVPSEGSGGSTTGWR ddPTM_A459_Selumetinib_30min_R1 4 TPAAPASPAAVPSEGSGGSTTGWR 24 0 P07199 P07199 CENPB Major centromere autoantigen B 1 T(0.042)PAAPAS(0.958)PAAVPSEGSGGSTTGWR;T(0.094)PAAPAS(0.906)PAAVPSEGSGGSTTGWR;T(0.002)PAAPAS(0.998)PAAVPSEGSGGSTTGWR;T(0.001)PAAPAS(0.999)PAAVPSEGSGGSTTGWR 244.33 3.2174e-45 360529000.0 14984.7 15384.800000000001 18859.0 19006.9 17629.0 14840.1 16551.8 15733.5 9035.3 13558.7 True False 15333.814354849448 13583.540463800515 16298.051385071813 15687.701718701197 16034.460062652739 14690.822067732712 15303.284400069368 15316.196470389405 15332.244187797667 15299.091217922103 1.0022696208835378 0.8878658392393982 1.0652953925772715 1.025400887885671 1.0480661781968585 0.9602414848355937 1.0002740804723325 1.0011180567671407 1.0021669894899854 1.0 13.901158337412705 -5.2635880255346255 24.99971817665358 1.0122424952228688 0.9450677330675895 0.343409815456176 0.03746692154223322 196.29714257889538 2283975.213312028 0.009577737477119767 0.021642713290097374 5.450194165328311e-06 5.2635880255346255 -0.06717476215527929 TPAAPAS(ph)PAAVPSEGSGGSTTGWR ddPTM_A459_Selumetinib_30min_R2 6 TPAAPASPAAVPSEGSGGSTTGWR 24 0 P07199 P07199 CENPB Major centromere autoantigen B 1 T(0.016)PAAPAS(0.822)PAAVPS(0.052)EGS(0.105)GGS(0.003)T(0.001)T(0.001)GWR;T(0.034)PAAPAS(0.96)PAAVPS(0.005)EGS(0.001)GGSTTGWR;T(0.004)PAAPAS(0.996)PAAVPSEGSGGSTTGWR;TPAAPAS(1)PAAVPSEGSGGSTTGWR;T(0.017)PAAPAS(0.965)PAAVPS(0.017)EGSGGSTTGWR;TPAAPAS(0.955)PAAVPS(0.043)EGS(0.001)GGSTTGWR 212.06 5.2863e-32 395750600.0 295366.3 269844.6 313514.0 348313.0 361177.2 255977.7 252257.9 275019.0 245002.3 288575.3 True False 278951.0234909811 290540.8131328555 293342.85056823323 300872.16852656024 315802.89117086475 291236.3046407969 263988.3921895458 275819.2597581533 294009.6059362269 280243.3812803258 0.99538844491727 1.036744603228396 1.0467431888241603 1.0736102567417982 1.1268879562046425 1.0392263442949075 0.941996884934384 0.9842132880999351 1.0491223899490807 1.0 18.096320774651062 -7.01622611598016 24.455970937165137 0.9922452907105165 1.0580667821943543 0.3594456787218362 0.03920961861920789 618.4480758621461 932122.2385377202 0.015646667474441475 0.012479286841600707 9.633273354177408e-08 7.01622611598016 0.06582149148383787 TPADRGPS(ph)PAPAPAASPQPGSR ddPTM_A459_Selumetinib_30min_R2 2 TPADRGPSPAPAPAASPQPGSR 22 1 Q8IX07 Q8IX07 ZFPM1 Zinc finger protein ZFPM1 1 TPADRGPS(1)PAPAPAASPQPGSR;T(0.001)PADRGPS(0.999)PAPAPAASPQPGSR 85.177 0.00035081 15906800.0 14252.0 13416.099999999999 24192.0 21556.0 21290.3 13410.7 14304.900000000001 13051.400000000001 14602.7 15711.5 True False 13459.930895276357 14445.071730439298 22635.513058258024 18620.0356138259 18615.622176303084 15257.902194786246 14970.106194621607 13089.377413224423 17523.648033528447 15257.868171620548 0.8821632710336079 0.9467293574673137 1.4835305170849364 1.220356304326901 1.2200670478283406 1.0000022298767635 0.981140092851623 0.8578772123336672 1.1484991111747984 1.0 13.897265782542283 -6.805680111455166 8.985847998380299 0.9871530204429774 1.1615448443555751 0.17132345480469724 0.16669088416210437 0.5581982035554456 105.61500745180001 0.06277404957409777 0.05558844028629393 1.5642994353660361e-07 6.805680111455166 0.17439182391259778 TPAPPEPGS(ph)PAPGEGPSGR ddPTM_A459_Selumetinib_30min_R2 2 TPAPPEPGSPAPGEGPSGR 19 0 P0C1Z6-2;P0C1Z6 P0C1Z6-2 TFPT TCF3 fusion partner 1 TPAPPEPGS(1)PAPGEGPSGR;TPAPPEPGS(1)PAPGEGPSGR 215.64 7.8898e-18 44322000.0 26324.0 19419.5 25204.6 27675.0 27194.0 22445.0 23881.0 28220.0 27797.0 20793.2 True False 24861.017463321285 20908.913206465808 23582.963476693563 23905.61725796214 23777.646602555433 25536.59501457621 24991.51381930376 28302.1155279275 33357.17671307295 20192.84628877829 1.2311794537423495 1.0354614157631385 1.167887039768101 1.183865657970523 1.1775282326478813 1.2646357353181847 1.237641958042944 1.4015911933948484 1.6519304032740758 1.0 14.301556660069629 -7.21062890768491 1.4000142012679637 1.3798087023506154 1.1516600929729313 0.18709291523600802 0.15821858702069605 0.580321637027022 2.233899017293023 0.09002733148873236 0.05513473365750083 6.15702748537777e-08 7.21062890768491 -0.2281486093776841 TPAQFDADELR ddPTM_A459_Selumetinib_30min_R1 1 TPAQFDADELR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 0 137.01 0.018958000000000003 53901000.0 1454.0 1631.7 1554.2 1765.6 1509.5 1248.2 1512.0 1582.7 1134.5 1272.7 False True 1487.8753710085023 1440.6598054432507 1343.148176609504 1457.2711044167559 1372.9659915238706 1235.6442412749218 1397.9486226818156 1540.7216546658603 1925.1636393984081 1436.063442147806 1.0360791364364832 1.0032006686895185 0.9352986345788902 1.0147679145966082 0.956062212314544 0.8604384771656515 0.9734588191946554 1.0728785438347526 1.3405839762337337 1.0 10.487903770348293 -7.960087829269098 4.286815166317242 1.1821495762029899 0.9669250576899012 0.45045629261134035 0.08939543781481304 0.1598010381983989 6.427056523099498 0.053026366248947444 0.022710627333709994 1.0962564729914005e-08 7.960087829269098 -0.21522451851308866 TPAQFDADELR ddPTM_A459_Selumetinib_30min_R2 3 TPAQFDADELR 11 0 P04083;Q5T3N1 P04083 ANXA1 Annexin A1;Annexin 0 ;; 166.29 0.0083573 90236000.0 156160.0 170927.0 186876.0 221329.0 198985.0 185442.0 147067.0 142664.0 158899.0 189438.0 False True 147481.25235801 184036.55128307 174852.6016152046 191183.60838617934 173986.72535152963 210984.95222513008 153905.9069077318 143079.1286207032 190683.24000901426 183968.43272096606 0.8016660802981458 1.000370273101186 0.950448938598135 1.039219639796339 0.9457422818588873 1.1468541048297198 0.8365886724771333 0.777737389532031 1.0364997798194697 1.0 17.48909870884963 -10.075434488463742 10.446723183672107 1.0000222867060182 0.9500689053272521 0.01920111659766066 0.11013217945644144 0.0 0.0 0.10737239630783468 0.02604163125016954 8.405537916193434e-11 10.075434488463742 -0.04995338137876615 TPAQYDASELK ddPTM_A459_Selumetinib_30min_R1 3 TPAQYDASELK 11 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 ;; 174.4 0.0018596 31277700.0 4003.8999999999996 4257.5 4262.4 4150.2 4218.8 4132.9 3593.7000000000003 3831.6000000000004 2941.9800000000005 3262.62 False True 4097.183079766808 3759.029920741947 3683.5894916872644 3425.4454789025935 3837.210284889634 4091.326778372958 3322.62431569553 3729.9735212091455 4992.325186282355 3681.409057610025 1.1129388274028706 1.0210845526583003 1.000592282477475 0.9304713019656655 1.0423210854435054 1.1113480502568907 0.902541462711721 1.0131918140144547 1.3560908630793067 1.0 11.846042347504783 -8.115379428547257 22.768764746951327 1.180268874328658 1.013701702273156 0.2869850508462196 0.10154959366012872 12.219679805267102 2390.4382044155664 0.06442274887835918 0.0243495161811515 7.666913640979319e-09 8.115379428547257 -0.16656717205550198 TPARPFGS(ph)VGR ddPTM_A459_Selumetinib_30min_R2 1 TPARPFGSVGR 11 1 J3KQR7;Q9Y4F5-3;Q9Y4F5-2;Q9Y4F5 J3KQR7 CEP170B Centrosomal protein of 170 kDa protein B 1 T(0.006)PARPFGS(0.994)VGR 82.417 0.022013 13073000.0 21831.0 17723.0 19328.0 18823.0 21031.0 20464.0 17845.0 20236.0 15204.0 24452.0 True False 20617.720416417214 19082.297111573072 18084.45752273525 16259.274928513862 18388.897760474498 23282.730246303745 18674.827859196674 20294.883409749847 18245.2248352542 23746.00722607424 0.8682605130254479 0.8036002402382749 0.7615788772639495 0.6847161619095444 0.7743995689634346 0.9804903209470182 0.786440755340579 0.8546650902836879 0.7683491654639134 1.0 14.535397331333979 -6.6032147255586535 24.999999992683605 0.8647692426078541 0.7736554002419196 0.26724437640296117 0.08069440747169931 46.172116168768184 14365.121723984159 0.026537025002266786 0.02653702548912837 2.493361644620666e-07 6.6032147255586535 -0.09111384236593456 TPAS(ph)KSPSEGQTATTSPR ddPTM_A459_Selumetinib_30min_R1 1 TPASKSPSEGQTATTSPR 18 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 T(0.395)PAS(0.563)KS(0.04)PS(0.002)EGQTATTSPR 75.143 0.008623899999999999 11721000.0 1630.1 1427.8 1969.3 1740.9 1557.9 1575.1 1777.5 1539.2 902.85 1139.9 True False 1668.078158377552 1260.6325122337882 1701.8798765905892 1436.8844957403317 1416.9882200695845 1559.2559240763746 1643.4217439265403 1498.3754159737753 1532.0705084450015 1286.2172685662654 1.2968867695556159 0.9801085267957907 1.3231667138847072 1.117139795006806 1.1016709654731103 1.2122803527699975 1.2777170576775474 1.1649473635539045 1.1911444091811847 1.0 10.328918648795545 -10.456962484671402 4.964093355953079 0.9999991284700152 1.1815357834382632 0.24415811452936875 0.09748174704632778 64320243.32065112 0.0015547241268543115 682.3845222988541 0.022229913946736617 3.4917047630251115e-11 10.456962484671402 0.181536654968248 TPAS(ph)KSPSEGQTATTSPR ddPTM_A459_Selumetinib_30min_R2 2 TPASKSPSEGQTATTSPR 18 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 T(0.176)PAS(0.637)KS(0.176)PS(0.01)EGQT(0.001)ATTSPR;T(0.171)PAS(0.734)KS(0.043)PS(0.049)EGQT(0.002)AT(0.001)TSPR 70.167 0.013311000000000002 11223400.0 14957.5 14359.5 13381.3 17856.5 15138.4 13125.5 13746.1 10883.1 9867.4 17045.4 True False 14126.222029616627 15460.827476930182 12520.361726457844 15424.413895819369 13236.578852986891 14933.418483574073 14385.320887380418 10914.76801920581 11841.15571819175 16553.255012732126 0.8533803181761702 0.9340052735874793 0.7563685641783241 0.9318054898541407 0.7996360137511217 0.9021439271060503 0.869032759799555 0.6593729155269216 0.7153369962031026 1.0 14.014827314345649 -7.6552137619764045 22.597339619032816 0.7651774504523139 0.8639714084468066 0.08474265559207605 0.0977956449606323 8.05860380672366 1680.9688063481053 0.043088697332785 0.02487721987651118 2.2120056810482728e-08 7.6552137619764045 0.09879395799449275 TPAS(ph)PHFR ddPTM_A459_Selumetinib_30min_R1 2 TPASPHFR 8 0 P29590-2 P29590-2 PML Protein PML 1 T(0.006)PAS(0.994)PHFR;TPAS(1)PHFR 88.681 0.020327 6291500.0 1268.3899999999999 1305.97 1533.19 1526.37 1446.04 1446.1799999999998 1242.15 1202.55 771.72 1237.51 True False 1297.9410191426919 1153.0664252710183 1324.9912192098343 1259.8181330134814 1315.2459373190977 1431.6327422263792 1148.4536254392983 1170.6544675670887 1309.5524758012689 1396.3564628681804 0.9295198279647456 0.8257679582064359 0.9488918155527718 0.902218141652567 0.9419127366786573 1.0252630902611641 0.8224645038562157 0.83836362612059 0.937835366988876 1.0 10.447451565439845 -5.283047172514741 24.89286609996319 0.9207524961261626 0.8776438642382306 0.08072231976352118 0.0639595486016662 2014.506727863157 2320772.4418747406 0.017241151944353297 0.035936509936846606 5.211381026722964e-06 5.283047172514741 -0.043108631887932014 TPAS(ph)PHFR ddPTM_A459_Selumetinib_30min_R2 2 TPASPHFR 8 0 P29590-2 P29590-2 PML Protein PML 1 TPAS(1)PHFR;TPAS(1)PHFR 94.309 0.01468 5300100.0 9676.5 12222.1 15109.4 16040.2 14077.8 11270.0 10729.900000000001 11232.8 12781.2 14156.3 True False 9138.718868098633 13159.495769754401 14137.277653870857 13855.497089111619 12309.22090687119 12822.340201126031 11228.8616108935 11265.485588309855 15337.797136566098 13747.570836515402 0.6647515387827617 0.9572233470367729 1.0283473220098158 1.0078505689390267 0.8953742485309651 0.9326986093476359 0.816788779954356 0.8194528125934224 1.1156732574039072 1.0 13.746889099880079 -4.759843413600135 24.97807491946191 0.9443981141750245 0.6647511898751127 0.4864052176634269 0.0883745495512911 37.66117080547953 589236.7728030494 0.022696961860555094 0.140165580955913 1.7384275119076455e-05 4.759843413600135 -0.2796469242999118 TPASGLQT(ph)PTSTPAPGSATR ddPTM_A459_Selumetinib_30min_R2 1 TPASGLQTPTSTPAPGSATR 20 0 Q96DF8 Q96DF8 DGCR14 Protein DGCR14 1 T(0.056)PAS(0.021)GLQT(0.918)PT(0.004)S(0.001)TPAPGSATR 100.95 0.0017053 3971800.0 9885.6 8213.1 8974.3 11298.0 10861.0 7033.9 8914.6 7933.7 5835.1 7599.5 True False 9336.197927192252 8843.018360721153 8396.903308479044 9759.192909862919 9496.544081428056 8002.7558776131655 9329.146563944782 7956.785753505264 7002.283046316215 7380.082689127728 1.265053295533701 1.1982275447602515 1.1377790279842375 1.3223690466558151 1.2867801732653048 1.0843721154239578 1.264097836964401 1.0781431711093332 0.9488082100532446 1.0 12.849421265517703 -7.961006828588937 3.633461302303183 0.9798715932843981 1.2192220197491566 0.6866985133851506 0.06829344702534595 0.1335499404175189 3.6489032484024637 0.04580411890627687 0.0186213508823549 1.0939391656860311e-08 7.961006828588937 0.23935042646475846 TPASKS(ph)PSEGQTATTSPR ddPTM_A459_Selumetinib_30min_R1 1 TPASKSPSEGQTATTSPR 18 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 T(0.328)PAS(0.167)KS(0.491)PS(0.013)EGQT(0.001)ATTSPR 64.275 0.019593 11250000.0 1116.9 1335.3 1530.1 1349.9 1214.5 1217.3 1439.8 1199.3 797.32 1261.2 True False 1142.9215968909193 1178.9624552358716 1322.320824237679 1114.1653057613148 1104.6486894373897 1205.0550672199672 1331.1947268103695 1167.4906681245766 1352.9938060512477 1423.0873051283204 0.8031282358940456 0.8284540596963333 0.929191638118397 0.7829212598174713 0.7762339565932556 0.8467892748936489 0.9354273079474453 0.8203928626988233 0.9507454680928713 1.0 10.47480845728684 -8.433482804477029 0.7325691032754847 1.0019832678179896 0.8300603644621231 0.5207206298539899 0.052132134574731266 0.6022160975817843 0.7385466917763849 0.052500480771486266 0.02065158656386024 3.6856763468758618e-09 8.433482804477029 -0.17192290335586657 TPAST(ph)PVSGTPQAS(ph)PMIER ddPTM_A459_Selumetinib_30min_R2 5 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2 T(0.001)PAS(0.136)T(0.863)PVSGTPQAS(1)PMIER;TPAS(0.029)T(0.955)PVS(0.014)GT(0.027)PQAS(0.974)PMIER;T(0.046)PAS(0.124)T(0.829)PVS(0.062)GT(0.105)PQAS(0.834)PMIER;T(0.003)PAS(0.099)T(0.898)PVS(0.01)GT(0.017)PQAS(0.974)PMIER;T(0.01)PAS(0.17)T(0.766)PVS(0.005)GT(0.049)PQAS(1)PMIER 196.75 5.251399999999999e-13 91864000.0 198227.5 184846.0 206155.0 220014.0 206693.0 156934.5 165973.3 176143.1 154740.0 192519.8 True False 187210.80911755518 199023.09382643065 192891.21174459305 190047.7136546803 180726.37748113525 178550.8028654494 173691.3873198549 176655.64725894 185692.32379684562 186961.25314748776 1.001334800477993 1.0645151895159137 1.0317175805001015 1.016508557015061 0.9666515090084787 0.9550150090435924 0.9290234441402428 0.944878386750981 0.9932128752386938 1.0 17.512379783672365 -6.191511404087263 2.549611388664367 0.9585991053713774 1.0352324687740342 0.6184595773208004 0.0245190549820664 0.1731842194896542 2.209793936456407 0.007835472263647503 0.010410999212415468 6.43411169512921e-07 6.191511404087263 0.0766333634026568 TPASTPVS(ph)GTPQASPMIER ddPTM_A459_Selumetinib_30min_R1 1 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 TPASTPVS(0.974)GT(0.025)PQAS(0.001)PMIER 185.59 2.3196e-15 7768800.0 662.34 1074.5 997.52 1278.8 1113.2 970.02 938.66 770.82 467.41 699.34 True False 677.771233310709 948.6970404785026 862.0622629851441 1055.4815860490178 1012.5112565514228 960.2624795076907 867.8561204804988 750.3753496237687 793.1606317242934 789.1071011484614 0.8589090534406357 1.2022411648530027 1.0924528010589492 1.3375644250481038 1.283110055755195 1.2168975264702737 1.0997950965305299 0.9509169902687191 1.0051368573035682 1.0 9.624077312332341 -7.5735758562747755 4.055021619813497 0.9850024036905058 1.1760896364839042 0.2985308035797012 0.12231200974473623 0.27202801801088133 9.41408164204456 0.06287879033211846 0.03537153696726404 2.669464462988553e-08 7.5735758562747755 0.19108723279339834 TPASTPVSGT(ph)PQAS(ph)PMIER ddPTM_A459_Selumetinib_30min_R1 1 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2 TPAST(0.012)PVS(0.051)GT(0.939)PQAS(0.998)PMIER 106.7 0.019236000000000003 6887100.0 1134.4 1350.9 1127.0 1063.4 1304.6 874.02 1348.7 1142.8 735.58 1092.3 True False 1160.8293128418472 1192.7359999836278 973.9595901678745 877.6971524902455 1186.5991603458372 865.2281523466648 1246.9664731554005 1112.4892316624412 1248.2255353624341 1232.5073449030006 0.9418437282685772 0.9677313526090973 0.7902261955643972 0.7121232632973242 0.9627522020481132 0.7020064877704717 1.0117314743090136 0.9026228007996131 1.0127530197077006 1.0 10.267380528769177 -7.306841797007064 24.998646643349108 0.9736620868558177 0.8483126630691784 0.3323394740227025 0.09388826483963514 590.3366614438456 325038.1765193429 0.039778221459447406 0.026818614480822518 4.933534879884382e-08 7.306841797007064 -0.12534942378663927 TPASTPVSGT(ph)PQASPMIER ddPTM_A459_Selumetinib_30min_R1 3 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 T(0.001)PAS(0.005)T(0.007)PVS(0.053)GT(0.726)PQAS(0.208)PMIER;TPASTPVS(0.015)GT(0.533)PQAS(0.452)PMIER;TPAS(0.001)T(0.034)PVS(0.127)GT(0.836)PQAS(0.002)PMIER 112.44 0.0015134 69977000.0 3594.71 4925.7 3901.7000000000003 4334.7 4348.6 3826.55 4161.7 3946.2 2419.6 3691.89 True False 3678.4597489119474 4348.996754104196 3371.870570503987 3577.726017396529 3955.2698978076883 3788.0583812294144 3847.7796183961095 3841.53395693588 4105.884479408012 4165.780043553914 0.8830182367895201 1.0439813693077218 0.8094211732858017 0.8588369957104832 0.9494668120867382 0.9093275068833789 0.9236636543857194 0.9221643766046244 0.985622005117965 1.0 12.024370950624547 -8.277621766175676 2.4400315951614364 1.001260394488588 0.9117235619912974 0.24097838513140968 0.057581614978473646 0.43605969601872996 4.771053280826038 0.053821599391600396 0.015397954062260287 5.276892341241435e-09 8.277621766175676 -0.08953683249729061 TPASTPVSGT(ph)PQASPMIER ddPTM_A459_Selumetinib_30min_R2 3 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 TPAST(0.001)PVS(0.297)GT(0.632)PQAS(0.07)PMIER;TPAS(0.006)TPVS(0.01)GT(0.623)PQAS(0.36)PMIER;T(0.002)PAS(0.164)T(0.125)PVS(0.207)GT(0.345)PQAS(0.157)PMIER 169.43 4.4583e-08 29480800.0 57770.0 57229.0 66275.0 65408.0 68349.0 35016.7 41017.6 45079.1 46011.0 57731.0 True False 54559.37467163311 61618.28027976168 62010.93865476399 56499.3175649065 59762.38757218737 39839.93257504612 42924.99967483246 45210.27271775323 55214.48565475411 56064.15602684821 0.9731596538348942 1.0990672944448443 1.1060710273613672 1.0077618494399505 1.0659642774889564 0.7106132580675507 0.7656407001699335 0.8064024489390826 0.984844677378409 1.0 15.77479107463483 -6.741430805923199 24.97672461120429 0.8359091524039094 1.0538318791301275 0.5310733911100212 0.09174302066091611 173.8264570727475 216987.31017506224 0.030313073554554485 0.030275262948624152 1.813715623546588e-07 6.741430805923199 0.21792272672621815 TPASTPVSGTPQAS(ph)PMIER ddPTM_A459_Selumetinib_30min_R1 2 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 TPASTPVS(0.019)GT(0.013)PQAS(0.968)PMIER;TPASTPVS(0.008)GT(0.011)PQAS(0.98)PMIER 184.97 5.570700000000002e-14 118285000.0 3336.0 4050.4 3368.1000000000004 4061.7 3807.4 3477.2000000000003 3994.0 3371.1 1820.45 3245.8 True False 3413.722309273976 3576.1772850201255 2910.730519648994 3352.400342551844 3463.0213422510665 3442.222525044991 3692.72936441215 3281.6874771239536 3089.170689592624 3662.430046769348 0.93209215348297 0.976449308069295 0.7947538881231512 0.9153486345791142 0.9455528974009535 0.939873930993275 1.008273009246833 0.8960409987949804 0.8434756842161669 1.0 11.838585488663114 -6.005309925676536 24.966671742594695 0.9365790516820215 0.8997031749539952 0.07228870341878124 0.06125239980889407 723.3847039592675 3401308.298738474 0.01802363586878677 0.025901343554939858 9.87847884931472e-07 6.005309925676536 -0.03687587672802628 TPASTPVSGTPQAS(ph)PMIER ddPTM_A459_Selumetinib_30min_R2 6 TPASTPVSGTPQASPMIER 19 0 Q9UHR4 Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 1 TPASTPVS(0.025)GT(0.432)PQAS(0.542)PMIER;TPASTPVSGTPQAS(1)PMIER;TPASTPVS(0.001)GTPQAS(0.999)PMIER;TPASTPVSGTPQAS(1)PMIER;TPASTPVS(0.002)GTPQAS(0.998)PMIER;TPASTPVS(0.02)GT(0.002)PQAS(0.979)PMIER 237.84 1.1505e-29 224065300.0 146969.0 135898.0 152985.0 150451.0 151387.0 83373.7 116676.1 111814.9 117464.7 125202.6 True False 138801.0513435218 146320.93961905787 143142.11165747384 129959.31425754866 132368.4116430485 94857.67038390611 122101.76983930609 112140.26284704676 140960.9222379427 121587.67562257852 1.1415717146725914 1.2034191694991696 1.1772748424092148 1.0688526908019578 1.0886663550830147 0.780158596652137 1.004228177026127 0.9222995856516119 1.1593356112464954 1.0 16.891637476086053 -6.153138256690251 1.914635858739308 0.9730324809297209 1.1748096537683725 0.4310032846086381 0.09404315718628459 0.3072326363505035 2.221587387791015 0.031498050831877386 0.04480424020938399 7.028485339845553e-07 6.153138256690251 0.2017771728386516 TPAT(ph)TPEAR ddPTM_A459_Selumetinib_30min_R2 2 TPATTPEAR 9 0 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H7C477 A0A0C4DG98 THOC2 THO complex subunit 2 1 T(0.04)PAT(0.48)T(0.48)PEAR;T(0.04)PAT(0.48)T(0.48)PEAR 105.17 0.029152 2621900.0 53453.0 45946.0 58709.0 60849.0 69672.0 49238.0 52888.0 51876.0 48513.0 62658.0 True False 50482.296249312894 49469.91046032485 54931.72685752607 52561.26122962017 60919.18048441722 56020.08756193824 55347.39679558384 52026.95057146591 58216.955566475044 60848.900734964845 0.8296336604205059 0.8129959598744003 0.9027562732281429 0.8637996840494696 1.0011549879883368 0.9206425569779951 0.9095874556001675 0.8550187422132067 0.9567462166662045 1.0 15.892943579735128 -5.48884168399339 1.5193945826205144 0.9283088272409863 0.815895767796593 0.4678275206595299 0.04588274450830605 0.4289656507301758 1.8355868083124711 0.01416871066997724 0.04780938720803137 3.2445787239381502e-06 5.48884168399339 -0.11241305944439328 TPDT(ph)PNNDPR ddPTM_A459_Selumetinib_30min_R1 1 TPDTPNNDPR 10 0 Q16513-3;Q16513-2;Q16513;B1AL79 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 T(0.097)PDT(0.903)PNNDPR 124.38 0.009028200000000002 2637700.0 1073.7 1545.8 1733.5 1701.4 1558.2 1444.3 1436.8 1415.4 861.02 1177.4 True False 1098.7151209434862 1364.8170173770764 1498.1002214339042 1404.2824292334992 1417.2610851225531 1429.7716533194757 1328.4210192256835 1377.8589941328491 1461.0880535873232 1328.5307588471967 0.8270151922540898 1.0273130737005791 1.1276368359990758 1.057019131760287 1.0667883115874188 1.0762051565596633 0.999917397756294 1.0371299158541545 1.0997773622156481 1.0 10.375615914916255 -4.773649966929448 4.186854504078482 1.0593252749279627 0.806780461588269 0.7687502422130762 0.03775804544828482 0.09837333470070765 3.4413310179360663 0.009423416394878438 0.07521507593053713 1.6840308109594358e-05 4.773649966929448 -0.2525448133396937 TPDT(ph)PNNDPR ddPTM_A459_Selumetinib_30min_R2 1 TPDTPNNDPR 10 0 Q16513-3;Q16513-2;Q16513;B1AL79 Q16513-3 PKN2 Serine/threonine-protein kinase N2 1 T(0.002)PDT(0.998)PNNDPR 130.44 0.0069881 0.0 21203.0 18141.0 25100.0 32007.0 23485.0 17859.0 18980.0 23289.0 19997.0 21916.0 True False 20024.62214233403 19532.356367491255 23485.093326813694 27647.591384845302 20534.604341436156 20318.9151421393 19862.60760815651 23356.767134298512 23996.958762863615 21283.228135393558 0.940863952354742 0.9177346708514278 1.1034554146303812 1.2990318578067555 0.9648256463166668 0.954691413016871 0.9332516421757193 1.0974259630970502 1.127505593146238 1.0 14.377429367875113 TPEAS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 1 TPEASPEPK 9 0 A0A087WW66;Q99460-2;Q99460 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 T(0.001)PEAS(0.999)PEPK 104.82 0.014102000000000003 7557000.0 2107.6 2319.3 2211.8 2480.1 2396.1 1950.1 2118.2 2038.9 1266.4 1599.4 True False 2156.7029793242905 2047.7552777866817 1911.4497085477403 2046.9970922428606 2179.373178065813 1930.4837645491311 1958.4224686273972 1984.8217487194188 2148.9883058035657 1804.69856947529 1.1950488662222105 1.134679947345478 1.0591517835044817 1.13425982979419 1.2076106308985763 1.0696987281983676 1.0851798199168528 1.099807902710589 1.1907740949938121 1.0 10.817542175160398 TPEDGDYS(ph)YEIIEK ddPTM_A459_Selumetinib_30min_R1 2 TPEDGDYSYEIIEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.223)PEDGDY(0.001)S(0.776)YEIIEK;T(0.042)PEDGDYS(0.958)YEIIEK 157.37 0.00031379 28719000.0 4650.6 5029.8 5743.4 5487.1 5002.4 4298.299999999999 4979.9 4764.1 3194.84 3700.1 True False 4758.949931507663 4440.908677709419 4963.477826237949 4528.880990623685 4549.93380324545 4255.063004544144 4604.262133659508 4637.740592022256 5421.4101381186565 4175.043877026084 1.1398562677855015 1.063679522542578 1.1888444702462557 1.0847505137717597 1.089793050626908 1.0191660566631118 1.102805687622895 1.1108243957727588 1.29852770361311 1.0 12.027575644125498 -8.025104382240448 24.957065175191126 1.1677345787005573 1.0973767834664376 0.05032107326224822 0.07931671110215185 1575.9498120689134 1566691.48978091 0.04965702365379124 0.018934546955780337 9.438339994729257e-09 8.025104382240448 -0.07035779523411967 TPEDGDYS(ph)YEIIEK ddPTM_A459_Selumetinib_30min_R2 2 TPEDGDYSYEIIEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TPEDGDYS(0.999)YEIIEK;TPEDGDYS(1)YEIIEK 109.07 0.0046837 13862700.0 53242.0 65721.0 64816.0 76108.0 75336.0 57024.0 73013.0 64555.0 48542.0 68977.0 True False 50283.02278461297 70761.5893736781 60645.8091263249 65741.95910637693 65871.61816761474 64878.538387667366 76408.24917251473 64742.844362344425 58251.756376802805 66985.454786231 0.7506558393173551 1.0563724557741345 0.9053578768683791 0.981436332949856 0.9833719630303203 0.9685466582963812 1.1406692604589228 0.9665209345664165 0.869617987407866 1.0 16.031560242494884 -4.750783776218104 24.995141505439676 0.9862994808826253 0.7506553428980548 0.4995673776623032 0.07059225362298946 395.8950374668172 928600.7378967588 0.01768440054035283 0.25116823784599773 1.7750730230230536e-05 4.750783776218104 -0.2356441379845705 TPEDGDYSYEIIEK ddPTM_A459_Selumetinib_30min_R2 1 TPEDGDYSYEIIEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 168.85 7.9291e-06 0.0 5792.3 5672.7 4624.5 5292.8 6289.5 4590.9 3315.4 4957.6 3552.2 4479.7 False True 5470.387154414067 6107.777849394609 4326.964704774894 4571.91150941073 5499.3567811565945 5223.25480295914 3469.5726693404667 4972.025795225138 4262.7392567607185 4350.359421341602 1.2574563673010404 1.4039708580012082 0.9946223485691917 1.0509273065996014 1.2641155013947456 1.2006490262242164 0.7975370155210049 1.1429000028902947 0.9798590975837435 1.0 12.086918884236361 -1.5228787452803605 0.27226715977505456 0.9900284714834637 3.4632139044046926 0.3245595790474938 0.1386662792409071 62.85657024455959 0.8798357345786921 0.16418222038089683 73.25388084070825 0.029999999999998417 1.5228787452803605 2.4731854329212286 TPEEIRR ddPTM_A459_Selumetinib_30min_R1 2 TPEEIRR 7 1 P09525;Q6P452;P09525-2;B4E1S2 P09525 ANXA4 Annexin A4;Annexin 0 ; 104.75 0.024142 42990000.0 4343.2 4830.5 5459.2 5095.1 5486.4 4529.6 4514.0 4748.4 2533.7 3612.8999999999996 False True 4444.388109603939 4264.942814361474 4717.870625239093 4205.336431872344 4990.156088702593 4484.036336547742 4173.50534575775 4622.457007023045 4299.503845873734 4076.650907626157 1.0902057130498612 1.0461878907470545 1.1572908085932527 1.0315664812028562 1.224082267963526 1.0999313991196777 1.0237583350466453 1.1338859057997468 1.054665690856847 1.0 11.993168705702537 -8.537392091055997 5.4248833786186355 1.000029298666226 1.0999614571110572 0.23312872212054891 0.05772632054956022 0.2168157087073936 31.131509492413645 0.05404907739326533 0.014033708433433257 2.9014020191225163e-09 8.537392091055997 0.09993215844483117 TPEELDDS(ph)DFETEDFDVR ddPTM_A459_Selumetinib_30min_R1 4 TPEELDDSDFETEDFDVR 18 0 G3XAM7;P35221-3;P35221;P35221-2 G3XAM7 CTNNA1 Catenin alpha-1 1 TPEELDDS(1)DFETEDFDVR;TPEELDDS(1)DFETEDFDVR;TPEELDDS(1)DFETEDFDVR;T(0.003)PEELDDS(0.822)DFET(0.176)EDFDVR 331.27 2.975099999999998e-144 161109500.0 5027.17 5671.360000000001 5547.9 5905.150000000001 5963.759999999999 4604.27 5336.23 5060.34 3073.3500000000004 4401.07 True False 5144.293279829993 5007.354534656268 4794.525652433319 4873.926405894092 5424.338960987346 4557.9552241426745 4933.71387487658 4926.123344899127 5215.250481397184 4965.990204552089 1.0359048382967935 1.0083295230961715 0.9654722331184631 0.981461139699066 1.0922975554835186 0.9178341149293069 0.9935005249011721 0.991972022092106 1.050193469293719 1.0 12.277865700454315 -8.22996280603175 24.542371978850877 1.0250967679905898 0.9973070292653196 0.05501508552266099 0.04417875235778669 1453.136885724115 1133019.264601578 0.029399542009529926 0.011109390094678139 5.88894087426465e-09 8.22996280603175 -0.02778973872527024 TPEELDDS(ph)DFETEDFDVR ddPTM_A459_Selumetinib_30min_R2 3 TPEELDDSDFETEDFDVR 18 0 G3XAM7;P35221-3;P35221;P35221-2 G3XAM7 CTNNA1 Catenin alpha-1 1 TPEELDDS(1)DFETEDFDVR;TPEELDDS(1)DFETEDFDVR;TPEELDDS(1)DFETEDFDVR 220.42 2.1298e-14 23132200.0 45370.9 38998.5 50529.7 46871.0 50462.7 36855.1 43214.5 43172.7 38414.1 44224.8 True False 42849.367012103154 41989.559550058264 47278.6741145776 40487.088943015115 44123.12448373811 41931.55548771252 45224.05987790724 43298.325409374746 46097.993379632884 42947.91511417016 0.9977054042831874 0.9776856324325812 1.1008374676371324 0.9427020807735759 1.0273635953327152 0.97633506483945 1.05299779413474 1.0081589593877391 1.0733464769381411 1.0 15.390300477677943 -7.274381463128209 24.8248481891045 1.0343057189610159 1.0052943857137302 0.10087315416508003 0.043503926441817595 1795.6388351370726 3444296.409544782 0.01729233756109916 0.01175034517961633 5.316410864798045e-08 7.274381463128209 -0.029011333247285664 TPEKLDNTPAS(ph)PPRSPAEPNDIPIAK ddPTM_A459_Selumetinib_30min_R1 1 TPEKLDNTPASPPRSPAEPNDIPIAK 26 2 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0Y8P9 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 TPEKLDNT(0.113)PAS(0.82)PPRS(0.066)PAEPNDIPIAK 65.587 0.0018231 11431000.0 448.54 596.44 1040.2 1396.6 968.58 542.85 690.84 524.23 222.32 496.4 True False 458.99010929309065 526.6085275225669 898.9465534096029 1152.710027428885 880.9721100166884 537.3894218683636 638.729382601525 510.3257174609742 377.2608023896469 560.1177753454637 0.8194528534824653 0.9401746395171456 1.6049241659134277 2.0579779435100565 1.5728336946159787 0.9594221885511812 1.1403483530005383 0.9111043068508596 0.6735383503174202 1.0 9.129586402733864 -6.774651209397111 23.93321471007918 0.9440429956743155 1.4216203229885982 0.31190877867517186 0.3423410153043749 196.95846405242955 356786.74627440097 0.1370079074262425 0.12162176370633641 1.6801528408382088e-07 6.774651209397111 0.4775773273142827 TPEQYYQT(ph)FSPSSSHSPAR ddPTM_A459_Selumetinib_30min_R2 1 TPEQYYQTFSPSSSHSPAR 19 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2;A8MXE8;Q7Z5J4-4 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 TPEQY(0.002)Y(0.005)QT(0.567)FS(0.403)PS(0.007)S(0.007)S(0.007)HS(0.001)PAR 70.391 0.021761000000000003 4882800.0 15213.0 13416.0 20152.0 24843.0 26927.0 13780.0 14970.0 17173.0 19792.0 19822.0 True False 14367.52236246416 14444.96406076085 18855.44225983863 21459.340543434628 23544.189529565738 15678.069917614612 15666.134662492259 17222.970586856798 23750.95303468504 19249.687356258946 0.7463769201317769 0.7503999308364943 0.9795194026207324 1.1147890428702065 1.2230946453221463 0.814458418334621 0.8138383950115682 0.8947143020095248 1.2338357810763367 1.0 14.232547394019969 -5.277193198040862 5.044423964077095 1.0041503934642912 0.7451560395049475 0.35622754747723695 0.1404547157205231 0.20503001905703402 16.13761976948499 0.03991998593439633 0.09448209719755817 5.2821022258110575e-06 5.277193198040862 -0.2589943539593438 TPEQYYQTFS(ph)PSSSHSPAR ddPTM_A459_Selumetinib_30min_R2 1 TPEQYYQTFSPSSSHSPAR 19 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2;A8MXE8;Q7Z5J4-4 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 TPEQYYQT(0.258)FS(0.737)PS(0.004)SSHSPAR 114.66 0.00031793 4762600.0 10667.0 13095.0 17154.0 23011.0 25224.0 16280.0 11786.0 13568.0 13394.0 17032.0 True False 10074.170843384292 14099.344392938528 16050.330315863035 19876.86210381089 22055.13561457891 18522.42222487416 12334.072353515943 13607.48063369668 16073.174259628699 16540.241905549516 0.6090703449750784 0.8524267343519306 0.9703806272916657 1.201727412290257 1.3334227963848013 1.1198398627204837 0.7457008442771121 0.8226893361898868 0.9717617403307681 1.0 14.013692714021428 -4.897811716311857 2.055771978274545 1.0262104299393737 0.5501200874869739 0.3878915526669219 0.1612336222273654 0.6684097167284453 3.851526251660925 0.0511346295700881 0.5527570316138736 1.265284779147339e-05 4.897811716311857 -0.4760903424523998 TPESQPDT(ph)PPGTPLVSQDEK ddPTM_A459_Selumetinib_30min_R2 2 TPESQPDTPPGTPLVSQDEK 20 0 M0R3C8;A0A0D9SEV0;M0R000;M0QYI1;A0A0D9SFD6;A0A0D9SFL2;M0QYH2;Q96T60-2;Q96T60 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 1 TPESQPDT(1)PPGTPLVSQDEK;TPESQPDT(1)PPGTPLVSQDEK 174.76 3.2972e-10 10973400.0 256420.0 191250.0 225410.0 226860.0 220830.0 196484.0 209751.0 233810.0 199564.0 194193.0 True False 242169.2029305894 205918.26003432542 210907.3660078515 195961.27664467218 193087.36115475156 223547.8874958341 219504.83711372138 234490.34839067087 239482.3762840487 188586.1435159922 1.2841304160294964 1.0919055673719922 1.1183608831258933 1.0391075027633436 1.0238682310101836 1.185388721186067 1.1639499754397769 1.2434123950935236 1.2698832046678998 1.0 17.524864151429895 -6.936816845414674 24.991716878489314 1.187463858247639 1.1065371169940281 0.08337246417194355 0.09428305755655034 126.69254262312319 50111.389889398575 0.03306706917401536 0.02916242009747156 1.1565999110974007e-07 6.936816845414674 -0.08092674125361077 TPESQPDT(ph)PPGTPLVSQDEKR ddPTM_A459_Selumetinib_30min_R1 2 TPESQPDTPPGTPLVSQDEKR 21 1 M0R3C8;A0A0D9SEV0;M0R000;M0QYI1;A0A0D9SFD6;A0A0D9SFL2;M0QYH2;Q96T60-2;Q96T60 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 1 TPESQPDT(0.999)PPGTPLVSQDEKR;T(0.006)PES(0.182)QPDT(0.811)PPGTPLVSQDEKR 185.96 1.5941e-16 333370000.0 10135.8 10946.099999999999 11685.7 13549.3 11936.0 10187.9 11239.7 10677.099999999999 5960.5 9117.2 True False 10371.944419166422 9664.52552329616 10098.8461249554 11183.169106861094 10856.390907471952 10085.41897587308 10391.880379865619 10393.908623891368 10114.533162304291 10287.481429048463 1.0082102690245898 0.9394452461422405 0.9816636068415717 1.0870657880638797 1.0553011426895096 0.9803584138091541 1.0101481544863224 1.0103453110051202 0.983188473492081 1.0 13.328602205847007 -5.544045761816308 24.99995496296957 1.0193886297952623 0.9705093784086363 0.23852256582266917 0.034107388995386775 299.9881985232973 354308.7669570519 0.0097069824867533 0.01681475254280408 2.857289453562274e-06 5.544045761816308 -0.04887925138662608 TPESQPDT(ph)PPGTPLVSQDEKR ddPTM_A459_Selumetinib_30min_R2 3 TPESQPDTPPGTPLVSQDEKR 21 1 M0R3C8;A0A0D9SEV0;M0R000;M0QYI1;A0A0D9SFD6;A0A0D9SFL2;M0QYH2;Q96T60-2;Q96T60 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 1 T(0.003)PES(0.035)QPDT(0.913)PPGT(0.05)PLVSQDEKR;T(0.002)PES(0.059)QPDT(0.926)PPGT(0.012)PLVSQDEKR;TPES(0.003)QPDT(0.996)PPGTPLVSQDEKR 128.51 7.3682e-05 347212000.0 552069.0 451865.0 517150.0 534758.0 532024.0 427839.0 460321.0 444300.0 303606.0 552309.0 True False 521387.2150873088 486521.59252502274 483877.13203034655 461923.03789099614 465186.3887650934 486769.9387142472 481726.83860875765 445592.8394421754 364335.6834604167 536362.4040988805 0.9720800919357298 0.9070762395108711 0.902145878108828 0.8612144221164294 0.8672986495886734 0.9075392588935247 0.8981368472648382 0.8307682194668302 0.6792714789033759 1.0 19.032848590648264 -1.5229034813198379 0.45040581562693205 0.8507934205862808 3.543138662191478 0.1592248422153374 0.07580942432101519 158.60664676823004 1.9089157388127715 0.047153916836788094 392.81282173102056 0.0299982913435859 1.5229034813198379 2.692345241605197 TPETLLPFAEAEAFLKK ddPTM_A459_Selumetinib_30min_R1 1 TPETLLPFAEAEAFLKK 17 1 Q3KQU3-4;Q3KQU3;Q3KQU3-2;Q3KQU3-3 Q3KQU3-4 MAP7D1 MAP7 domain-containing protein 1 0 166.04 2.0812e-06 2122700.0 529.08 515.05 507.28 386.2 448.83 329.24 391.9 604.52 293.72 386.25 False True 541.4065345895311 454.74770655975095 438.39416228958237 318.75741987185694 408.2334057473726 325.9281445260019 362.33866747949986 588.4861658422989 498.42138753997403 435.82894989360426 1.2422454605681903 1.0434086736798123 1.0058858237769757 0.7313819330947906 0.936682627088062 0.7478350040894906 0.8313781532134452 1.3502686454994826 1.143616980151617 1.0 8.767618220282605 -7.751776779045205 24.9981142403344 1.1852071318306003 0.9262171891463741 0.29537423621935954 0.16190016213124028 229.03383374723103 592537.1837557238 0.08127149084843086 0.04614903743465196 1.7710190020549104e-08 7.751776779045205 -0.25898994268422626 TPGDFSYAYQKPEET(ph)TRSPDEEDYDYESYEK ddPTM_A459_Selumetinib_30min_R1 6 TPGDFSYAYQKPEETTRSPDEEDYDYESYEK 31 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.005)PGDFS(0.021)Y(0.05)AY(0.135)QKPEET(0.485)T(0.151)RS(0.151)PDEEDY(0.001)DYESYEK;T(0.001)PGDFS(0.01)Y(0.037)AY(0.143)QKPEET(0.577)T(0.116)RS(0.116)PDEEDY(0.001)DYESYEK;T(0.002)PGDFS(0.009)Y(0.032)AY(0.032)QKPEET(0.658)T(0.134)RS(0.134)PDEEDYDYESYEK;TPGDFS(0.001)Y(0.009)AY(0.009)QKPEET(0.428)T(0.125)RS(0.428)PDEEDY(0.001)DYESYEK;TPGDFSY(0.001)AY(0.006)QKPEET(0.586)T(0.132)RS(0.274)PDEEDYDYESYEK;T(0.004)PGDFS(0.011)Y(0.033)AY(0.107)QKPEET(0.575)T(0.135)RS(0.135)PDEEDYDYESYEK 93.179 3.0101e-07 927929000.0 10735.33 12340.7 13435.8 14151.4 11899.9 10701.48 10723.949999999999 10498.74 7305.66 9690.76 True False 10985.442301684112 10895.845106964212 11611.292157566573 11680.123644677884 10823.556146097984 10593.832827366412 9915.033817598318 10220.279310486292 12397.171435705048 10934.663441995977 1.0046438429456468 0.99644997441049 1.0618792447668683 1.0681740418108225 0.9898389834778754 0.9688302601687253 0.9067525370299335 0.9346679360275506 1.133749703542966 1.0 13.416621195908416 -6.440611756474833 7.554653200550442 0.9795488739363716 1.0321493585909194 0.10437362034744779 0.05986580581213156 0.5968648395956593 48.662813861637055 0.01922299685489295 0.02175601191752656 3.6256697531747e-07 6.440611756474833 0.05260048465454781 TPGDFSYAYQKPEET(ph)TRSPDEEDYDYESYEK ddPTM_A459_Selumetinib_30min_R2 3 TPGDFSYAYQKPEETTRSPDEEDYDYESYEK 31 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.005)PGDFS(0.036)Y(0.093)AY(0.31)QKPEET(0.347)T(0.104)RS(0.104)PDEEDYDYESYEK;T(0.01)PGDFS(0.033)Y(0.109)AY(0.109)QKPEET(0.499)T(0.119)RS(0.119)PDEEDY(0.001)DYESYEK;T(0.003)PGDFS(0.009)Y(0.031)AY(0.135)QKPEET(0.571)T(0.123)RS(0.123)PDEEDY(0.003)DY(0.001)ES(0.002)YEK 60.993 0.0019703 230815000.0 69261.0 72025.0 76397.9 83596.0 78988.0 61146.0 59102.7 59648.8 52133.7 71207.0 True False 65411.750893750745 77549.08590312315 71482.54228974433 72210.0805888564 69064.82127832054 69568.306471877 61851.09265977825 59822.36813260956 62561.8967372857 69151.06889199522 0.9459253767416843 1.1214445003625977 1.0337156523406827 1.0442366509422862 0.9987527652853871 1.006033711214695 0.8944343688509203 0.8650967959156806 0.9047133723268843 1.0 16.07746393133393 -7.122075734658055 2.7519470885392407 0.9042531718524167 1.034531975507137 0.500551114393329 0.05278209028036298 0.20466486103689352 2.9999958259036004 0.02175717352614423 0.016183750272436483 7.549605620144218e-08 7.122075734658055 0.13027880365472022 TPGFSVQSIS(ph)DFEK ddPTM_A459_Selumetinib_30min_R1 1 TPGFSVQSISDFEK 14 0 Q9NY61 Q9NY61 AATF Protein AATF 1 TPGFSVQS(0.251)IS(0.749)DFEK 129.38 0.0010577 8167300.0 962.69 1160.4 1498.2 1486.3 1040.7 1260.2 1204.6 1207.0 897.37 916.38 True False 985.118803931345 1024.539828544676 1294.7526690235225 1226.7456063064242 946.5688687505082 1247.5235321700509 1113.7360521709766 1174.986439111452 1522.7713486883652 1034.006299297091 0.9527203118598222 0.9908448616233285 1.2521709683042404 1.1864005152970112 0.9154382032236922 1.206495098741765 1.0771076084624294 1.1363435985933532 1.472690591656485 1.0 10.014029259422276 -8.017018416996653 24.62271468257611 1.2590692439101347 1.089583323122365 0.13852048119949845 0.14872476645534635 1024.6154161809834 1482432.138218052 0.09236306616127911 0.03678799792348215 9.61571500443019e-09 8.017018416996653 -0.1694859207877697 TPGHQNSVQPGAAS(ph)PSNPCPATR ddPTM_A459_Selumetinib_30min_R1 2 TPGHQNSVQPGAASPSNPCPATR 23 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 TPGHQNSVQPGAAS(0.834)PS(0.16)NPCPAT(0.006)R;TPGHQNSVQPGAAS(0.973)PS(0.025)NPCPAT(0.002)R 151.03 4.4236000000000006e-08 5799600.0 1141.8600000000001 1313.51 1976.4099999999999 1805.74 1677.01 1402.8 1483.58 1198.7399999999998 442.53 825.1800000000001 True False 1168.4631163272143 1159.723638565767 1708.0243776430234 1490.4014069378743 1525.3247416001639 1388.689105640491 1371.6723661628896 1166.9455211437132 750.9410888875966 931.0998909338632 1.254927777035054 1.2455415899604516 1.8344158282844711 1.60068905758656 1.6381966708967308 1.4914501861316733 1.473174231378275 1.253297881898906 0.806509694823857 1.0 9.862792142117618 -8.003475527773926 2.610043003536646 0.9052938690208105 1.5184882868982972 0.6616111009634678 0.1707857399181364 0.18317695444525167 2.370736376120969 0.14275264326462903 0.05006997503575317 9.92029237899564e-09 8.003475527773926 0.6131944178774866 TPGHQNSVQPGAAS(ph)PSNPCPATR ddPTM_A459_Selumetinib_30min_R2 2 TPGHQNSVQPGAASPSNPCPATR 23 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 TPGHQNSVQPGAAS(0.976)PS(0.024)NPCPATR;TPGHQNSVQPGAAS(0.99)PS(0.01)NPCPATR 181.14 5.0353999999999996e-17 3988800.0 18539.1 16809.8 17895.0 21357.7 22450.4 14213.7 21487.2 17071.8 17429.0 16681.8 True False 17508.771039897412 18099.057607973882 16743.655182602834 18448.744415912475 19629.980042877505 16171.50815587801 22486.397376079065 17121.47611161137 20915.287006948525 16200.153089478383 1.0807781224776787 1.1172152206221306 1.033549194882451 1.1388006220690903 1.2117157124661195 0.9982318109315289 1.3880361038491327 1.0568712540581708 1.2910548987671302 1.0 13.983719826016616 -5.9586609332365885 8.374953349426084 1.1650637348289723 1.0816882670224415 0.08368610404739474 0.11753035293817618 0.6253628502376383 113.25698033557349 0.030919083825735102 0.04583224316427876 1.0998642013748151e-06 5.9586609332365885 -0.08337546780653082 TPGNQTPVMPSAS(ph)PILHSQGK ddPTM_A459_Selumetinib_30min_R2 1 TPGNQTPVMPSASPILHSQGK 21 0 Q9UIF8-4;Q9UIF8-2;Q9UIF8-5;Q9UIF8-3;Q9UIF8;A0A0A0MR97 Q9UIF8-4 BAZ2B Bromodomain adjacent to zinc finger domain protein 2B 1 TPGNQTPVMPS(0.406)AS(0.584)PILHS(0.01)QGK 68.024 0.005331 3513900.0 18224.0 17707.0 19994.0 25288.0 24315.0 20962.0 20798.0 20555.0 18494.0 21507.0 True False 17211.183036452167 19065.06996302119 18707.607807821238 21843.730775766802 21260.332321142007 23849.325225909844 21765.148210455172 20614.811646936567 22193.316765534815 20886.037028103183 0.8240521173688278 0.9128141416855772 0.8956992550884229 1.0458533012449895 1.0179208383349694 1.1418789114382693 1.0420908562581357 0.9870140333083931 1.062591085885399 1.0 14.35025115714921 -5.728623989547111 4.140364099762673 1.045908560794987 0.8762645282801181 0.7408138745150858 0.04477727558354777 0.10711963921910074 3.9956688773943374 0.01286544964940108 0.022161546270801274 1.8679962947479069e-06 5.728623989547111 -0.16964403251486881 TPGRQS(ph)PGPGHR ddPTM_A459_Selumetinib_30min_R2 1 TPGRQSPGPGHR 12 1 O15169-2;O15169 O15169-2 AXIN1 Axin-1 1 TPGRQS(1)PGPGHR 66.708 0.040965 1646700.0 4366.8 3185.1 4393.9 4574.7 4461.1 3939.5 3831.5 4225.6 3793.7 4730.0 True False 4124.110737685433 3429.386928289308 4111.201257716601 3951.6179682023258 3900.65673525999 4482.1303657795925 4009.672341973218 4237.895796414261 4552.5460048345085 4593.432609984099 0.8978276352027965 0.7465847916948496 0.895017214094022 0.8602755942502017 0.8491812259924485 0.9757692658944023 0.8729141542771209 0.9225988832845707 0.9910988995330592 1.0 12.16535694779589 -7.223353003938858 0.3721329634227818 1.0069686055220608 0.8128703946141104 0.5187904916150494 0.05050063385865829 1.0856932083978978 0.3638865293126725 0.05756736624931498 0.07521178775700156 5.979253908111753e-08 7.223353003938858 -0.19409821090795043 TPGVLLPGAGGAAGFGMTSPPPPT(ph)SPSR ddPTM_A459_Selumetinib_30min_R1 1 TPGVLLPGAGGAAGFGMTSPPPPTSPSR 28 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4;A0A0A0MR72;A0A0A0MR80;Q6ZTU2-4;Q6ZTU2-5;Q6ZTU2-2;Q6ZTU2-6;Q6ZTU2 Q96L91-3 EP400;EP400NL E1A-binding protein p400;EP400 N-terminal-like protein 1 TPGVLLPGAGGAAGFGMTSPPPPT(0.333)S(0.333)PS(0.333)R 82.744 0.001097 0.0 2673.8 3109.0 3344.6 3549.0 3033.6 3255.4 2841.0 2448.3 1565.1 2379.4 True False 2736.0943376908763 2744.996834665111 2890.4216905727335 2929.2337729808937 2759.2114156255802 3222.6536316667066 2626.701082697777 2383.3631308008016 2655.860389618731 2684.8191673186843 1.019098183965738 1.0224140486178537 1.0765796541371475 1.0910357794809342 1.0277084763146975 1.2003242791525341 0.9783530729635883 0.8877183088576706 0.9892138814962074 1.0 11.390609205201189 -7.502454731830778 24.981147592145394 0.9496867815758335 1.0711623636551841 0.4712968205950234 0.0565829662052206 608.8871442710057 744748.6894967047 0.023507756793517607 0.01563232501556222 3.1444541616204165e-08 7.502454731830778 0.12147558207935061 TPGVLLPGAGGAAGFGMTSPPPPT(ph)SPSR ddPTM_A459_Selumetinib_30min_R2 1 TPGVLLPGAGGAAGFGMTSPPPPTSPSR 28 0 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4;A0A0A0MR72;A0A0A0MR80;Q6ZTU2-4;Q6ZTU2-5;Q6ZTU2-2;Q6ZTU2-6;Q6ZTU2 Q96L91-3 EP400;EP400NL E1A-binding protein p400;EP400 N-terminal-like protein 1 TPGVLLPGAGGAAGFGMTSPPPPT(0.423)S(0.423)PS(0.153)R 110.61 7.4443e-10 4437900.0 23350.0 29359.0 26908.0 30213.0 32204.0 24729.0 21870.0 23806.0 21622.0 28015.0 True False 22052.300477456003 31610.740895936022 25176.768575215257 26097.937279667945 28158.24561258717 28135.195282488523 22886.998334582873 23875.271518704558 25947.00416915721 27206.134158288492 0.8105635423670677 1.1618975600142603 0.9254077932841855 0.9592666539033834 1.0349962052219246 1.034148957687066 0.8412440445020091 0.877569425328693 0.9537188936213608 1.0 14.731644351686686 -7.250416062218249 24.869496561846592 0.9079305402783152 0.9936550153868369 0.11221201266478786 0.09325201775046447 1214.404618827551 2739798.8805635213 0.034078104021704136 0.026139211583766725 5.618028496826624e-08 7.250416062218249 0.08572447510852166 TPGVVASAPTKPQS(ph)PAQNATSSQDSSQDTLTEQITLENQVHQR ddPTM_A459_Selumetinib_30min_R2 1 TPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQVHQR 43 1 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4;A0A0A0MR72;A0A0A0MR80 Q96L91-3 EP400 E1A-binding protein p400 1 TPGVVASAPT(0.001)KPQS(0.952)PAQNAT(0.014)S(0.014)S(0.014)QDS(0.001)S(0.001)QDT(0.002)LTEQITLENQVHQR 103.24 1.4461e-17 6718400.0 7532.6 7972.4 12048.0 10820.0 11066.0 7243.4 8606.3 9644.1 6849.3 7997.4 True False 7113.968247386941 8583.857444693638 11272.844796870568 9346.297334458908 9675.790148704811 8241.112600961515 9006.510003059922 9672.1627343333 8219.351385431895 7766.49428225937 0.9159819075174028 1.1052422280540823 1.4514714602469463 1.2034126331372195 1.245837542275252 1.0611110111529074 1.1596622202675229 1.2453704828479635 1.0583090757186244 1.0 12.923047812134087 -6.755310359696694 24.947043031587036 1.1236494428402517 1.1958868584573117 0.06451083491463327 0.13929141444572554 506.51026619339154 2061651.6015728957 0.04887612729651751 0.04771234420621672 1.7566677984650644e-07 6.755310359696694 0.07223741561705999 TPHDILEDINAS(ph)PEMR ddPTM_A459_Selumetinib_30min_R1 6 TPHDILEDINASPEMR 16 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR 278.46 1.2173999999999995e-62 97471500.0 8200.81 9074.5 9266.22 10432.1 9931.9 7687.61 8800.17 8106.26 4446.25 7600.19 True False 8391.872917001534 8012.053321379404 8007.918219703073 8610.329569770072 9033.56139861937 7610.2796231914 8136.3660918424885 7891.25565195658 7544.961508748505 8575.748418619734 0.978558664195539 0.9342686993922967 0.9337865138762952 1.0040324353586743 1.0533846094418566 0.8874187128283637 0.9487645502958955 0.9201827370335424 0.8798021047780301 1.0 13.066046867634366 -6.795735786822145 24.99998273224312 0.9235907485740273 0.9768991277952662 0.26038959233584014 0.04469301028599378 274.22637904039146 199892.44001173327 0.01618914302191515 0.01427816460649776 1.6005314531233194e-07 6.795735786822145 0.05330837922123888 TPHDILEDINAS(ph)PEMR ddPTM_A459_Selumetinib_30min_R2 6 TPHDILEDINASPEMR 16 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR;TPHDILEDINAS(1)PEMR 166.61 1.0675e-05 33588100.0 56294.3 49868.700000000004 55659.899999999994 61695.5 63888.9 41322.8 46671.9 50862.0 43547.4 49364.0 True False 53165.688169937996 53693.468936856334 52078.80263191699 53292.46646932623 55862.60520798722 47014.64060896991 48842.23582861536 51009.999999342625 52258.09681601875 47938.733056924946 1.1090340686894309 1.120043553781405 1.0863616810664543 1.1116786588006817 1.165291647187527 0.980723469540638 1.0188470306592698 1.0640665021074023 1.0901017503730182 1.0 15.548904160946918 -6.759582664239118 24.999999921129174 1.0340081138346628 1.1164062595527242 0.621817464621801 0.034143918611875705 37.795922131874114 508910.2175753801 0.012165504275660438 0.011585370384169805 1.7394715729936307e-07 6.759582664239118 0.08239814571806137 TPHPS(ph)PAHSSR ddPTM_A459_Selumetinib_30min_R2 1 TPHPSPAHSSR 11 0 A0A0A0MTL6;Q6ZS17-2;Q6ZS17;Q6ZS17-3;Q6ZS17-4 A0A0A0MTL6 FAM65A Protein FAM65A 1 T(0.005)PHPS(0.984)PAHS(0.007)S(0.005)R 76.311 0.034145 1228900.0 2325.9 3499.8 5206.8 5249.9 7761.3 3454.4 2864.1 4105.0 4588.0 6375.5 True False 2196.6357893154145 3768.2234063693195 4871.800156735201 4534.854563417361 6786.25610709765 3930.2122440789503 2997.286325106485 4116.944870380666 5505.728199430823 6191.422749461656 0.354786917030728 0.608619950349371 0.786862786450627 0.7324414350177697 1.096073775238125 0.6347833774427182 0.48410299964852166 0.6649432669960444 0.8892508914707118 1.0 12.59605525431782 -4.843193341549014 2.186664421176468 0.7674555983360705 0.27704578201939 0.38058006012033874 0.16963430356418976 0.6536617523088124 4.069856547077638 0.047462354784141854 0.6051298970754407 1.4348505166898507e-05 4.843193341549014 -0.49040981631668046 TPHS(ph)PPLAK ddPTM_A459_Selumetinib_30min_R1 1 TPHSPPLAK 9 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 T(0.029)PHS(0.971)PPLAK 72.652 0.044176 27137000.0 5364.1 6585.4 6624.4 7414.7 7214.4 5526.2 6346.0 6203.9 3142.4 5071.0 True False 5489.073093278343 5814.378306530602 5724.842865224549 6119.8618361570625 6561.858793805771 5470.611445388138 5867.316110806086 6039.352418892737 5332.4232881847165 5721.912245722894 0.959307458338146 1.0161599928200271 1.000512174842221 1.0695483560992454 1.1467947273589758 0.9560809761592198 1.025411760760903 1.0554779869976385 0.9319302812046237 1.0 12.482281656557504 -10.393208186170263 13.817631723737783 0.9999999806242729 1.0221663858465069 0.003502334919974426 0.059886168834007845 0.0 0.0 0.05842640234204072 0.014170484010651118 4.043819980967031e-11 10.393208186170263 0.02216640522223401 TPHS(ph)PPLAK ddPTM_A459_Selumetinib_30min_R2 4 TPHSPPLAK 9 0 Q8IZW8 Q8IZW8 TNS4 Tensin-4 1 T(0.008)PHS(0.992)PPLAK;T(0.011)PHS(0.989)PPLAK;T(0.005)PHS(0.995)PPLAK;TPHS(1)PPLAK 118.23 0.0048152 266744000.0 823270.0 708620.0 855980.0 820810.0 795040.0 534756.0 571760.0 574994.0 519059.0 703290.0 True False 777515.9492109293 762968.8754275762 800907.1787205575 709014.2620237718 695159.967452221 608413.7849683538 598347.9729209462 576667.1373446194 622885.3037202201 682984.1903331315 1.1384098786118155 1.1171105952766367 1.1726584451829083 1.038112260955768 1.0178273191260119 0.8908167913397742 0.8760788044436237 0.8443345329316407 0.9120054498134172 1.0 19.38149265794197 -6.351679738232491 1.4680044970717945 0.8912382430762321 1.1389404943375803 0.8261558475272789 0.04637302203638002 0.14449955824973862 0.6264880432223263 0.017224286183245778 0.022004223277421287 4.449592728177285e-07 6.351679738232491 0.24770225126134815 TPHVQAVQGPLGS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 TPHVQAVQGPLGSPPK 16 0 Q15149 Q15149 PLEC Plectin 1 TPHVQAVQGPLGS(1)PPK;TPHVQAVQGPLGS(1)PPK 105.46 0.0024234 158977000.0 9325.1 10631.9 10988.9 11977.7 8823.400000000001 8345.8 8902.4 9239.7 5909.6 9193.0 True False 9542.356686514022 9387.11220536378 9496.667737706968 9886.019544275361 8025.325027897795 8261.848829380107 8230.884800636644 8994.633141224584 10028.159579893205 10373.011097402985 0.9199215731007048 0.9049553805754591 0.9155169746308841 0.9530520551308821 0.7736736182521811 0.7964754642409055 0.7934904073029818 0.8671188198648032 0.9667549263881422 1.0 13.340547122757847 -6.23230506994988 24.97542864329947 0.8524811959865838 0.9214864503457053 0.11953806326036365 0.07012095771330883 1274.264593907456 1092365.1332646173 0.021052252128352014 0.027173401508383415 5.857265766191325e-07 6.23230506994988 0.06900525435912153 TPHVQAVQGPLGS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 4 TPHVQAVQGPLGSPPK 16 0 Q15149 Q15149 PLEC Plectin 1 TPHVQAVQGPLGS(1)PPK;TPHVQAVQGPLGS(1)PPK;TPHVQAVQGPLGS(1)PPK;TPHVQAVQGPLGS(1)PPK 131.25 0.00071868 261625200.0 598396.0 509626.0 552872.0 495279.0 455806.0 391981.0 498569.0 445756.0 348175.8 476893.0 True False 565139.5458889836 548712.6754941343 517300.8174415201 427821.14579607005 398543.57532265893 445972.8247007621 521753.4463957318 447053.0761611216 417820.6888446785 463123.85997318017 1.2202773269373581 1.1848076139413561 1.1169815726433905 0.9237726292505108 0.8605550475109162 0.9629666342964681 1.1265959098413694 0.9652991668082287 0.9021791467813272 1.0 18.821038560518033 -5.585732055102073 3.5996654262126664 0.9645073954963368 1.195615678367067 0.682920338480362 0.06730082327869971 0.14364318007625707 3.753923169494697 0.020790187142955507 0.039812583068430774 2.595780376230403e-06 5.585732055102073 0.23110828287073026 TPHVQAVQGPLGS(ph)PPKR ddPTM_A459_Selumetinib_30min_R2 1 TPHVQAVQGPLGSPPKR 17 1 Q15149 Q15149 PLEC Plectin 1 TPHVQAVQGPLGS(1)PPKR 102.07 0.0019163 113410000.0 27699.0 31893.0 33638.0 27192.0 31293.0 32373.0 28228.0 29574.0 24669.0 30924.0 True False 26159.600467882403 34339.09054784183 31473.767702285197 23488.402691183597 27361.693577030503 36832.086897165296 29540.65793272087 29660.055443760757 29603.489309450517 30031.143769798804 0.8710823892824933 1.1434493075277194 1.0480375953558314 0.7821348021651111 0.9111106052692916 1.2264630071867575 0.9836674273601528 0.9876432170255455 0.9857596346104419 1.0 14.87417180214991 TPHYGSQT(ph)PLHDGSR ddPTM_A459_Selumetinib_30min_R1 3 TPHYGSQTPLHDGSR 15 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 TPHYGSQT(1)PLHDGSR;TPHYGSQT(0.98)PLHDGS(0.02)R;TPHYGSQT(1)PLHDGSR 115.63 0.0034605 6101300.0 3822.32 4632.3 4451.5 4742.5 5920.6 4811.799999999999 5241.5 4088.1 1925.67 3433.08 True False 3911.372619059983 4089.9481625021535 3847.010750339212 3914.3114027506017 5385.082775366829 4763.397660764836 4846.129435044141 3979.67030797972 3267.721344627883 3873.7492590310326 1.0097123890869388 1.0558112797226324 0.9930975117634462 1.0104710297459252 1.3901474812321324 1.229660812366657 1.251017841112498 1.0273432898894395 0.8435552035304579 1.0 11.919514858515564 -7.998860496598797 23.83783819111078 0.9263347891519458 1.1349037304681493 0.31802442237536976 0.12546345096968178 25.37998786061042 530947.4535885873 0.07717696284147052 0.036538980809362305 1.0026272487300509e-08 7.998860496598797 0.20856894131620352 TPIS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 TPISPLK 7 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 T(0.001)PIS(0.999)PLK;T(0.229)PIS(0.771)PLK 96.665 0.022999 110252000.0 232710.0 221940.0 235800.0 248500.0 245650.0 180225.0 206496.0 200082.0 164325.0 212352.0 True False 219776.90981193958 238962.08435042258 220628.88471962765 214653.8713135891 214789.25086113668 205049.3578303408 216098.47316406155 200664.20549464185 197194.5916241217 206220.84600324364 1.0657356618956102 1.1587678403116626 1.0698670333073765 1.040893175805383 1.0415496542854754 0.9943192543547008 1.0478982961822518 0.9730549039231737 0.9562301554180417 1.0 17.653830650524995 -6.105514513241334 0.6446749906161703 0.9828411792224168 1.124602746472631 0.6623141887642047 0.0321685780466054 0.5753266843749645 0.4784533123322884 0.02048849600440074 0.04792777163263063 7.843059085302256e-07 6.105514513241334 0.14176156725021416 TPITSVPLGPLASS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 TPITSVPLGPLASSPTK 17 0 Q15911 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 TPITSVPLGPLAS(0.227)S(0.747)PT(0.026)K;TPITSVPLGPLAS(0.201)S(0.708)PT(0.091)K 142.57 0.00049852 48901000.0 6402.3 4777.1 6614.6 6346.7 5118.9 4799.4 5031.0 6266.8 3633.7 5678.8 True False 6551.461133292803 4217.794911186459 5716.373651397004 5238.367987314125 4655.896398815199 4751.122393506537 4651.507619518663 6100.584106564743 6166.123505052442 6407.72929619625 1.0224310095593263 0.658235502191115 0.8921059843758307 0.8175076919094755 0.7266062880619859 0.7414674019276835 0.7259213684760194 0.9520664535853856 0.9622946320021306 1.0 12.645597484954804 -7.836803870853067 6.872709302038385 0.971395589693659 0.7920818550788521 0.40249954090858786 0.09693541038448093 0.21666143126310602 16.05667372256289 0.05124970378237879 0.02447793838685306 1.456116520237442e-08 7.836803870853067 -0.17931373461480693 TPITSVPLGPLASS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 1 TPITSVPLGPLASSPTK 17 0 Q15911 Q15911 ZFHX3 Zinc finger homeobox protein 3 1 TPITSVPLGPLAS(0.027)S(0.588)PT(0.385)K 172.26 5.805600000000001e-07 22561000.0 195170.0 144670.0 173750.0 205440.0 163940.0 160760.0 149440.0 162060.0 137090.0 146440.0 True False 184323.23272741298 155765.7238126324 162571.11416469637 177458.7175962326 143344.3915578048 182903.230766018 156389.25610974216 162531.56776952263 164511.83061464073 142211.89670318612 1.2961168298888415 1.095307266295272 1.1431611414620428 1.247847203434822 1.0079634326021425 1.2861317161654888 1.0996917960819124 1.1428830606819498 1.1568077947655626 1.0 17.11768263276104 -14.52287874525419 0.19474427039068276 0.29575274465972 1.1874497221713285 0.26873914252932496 0.08454126283386311 190.48846052626178 1.8689176051006 52.110471374599754 0.20303769796964974 3.000000000180625e-15 14.52287874525419 0.8916969775116085 TPKDS(ph)PGIPPSAGAHQLFR ddPTM_A459_Selumetinib_30min_R1 2 TPKDSPGIPPSAGAHQLFR 19 1 E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q5SVM6 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 T(0.138)PKDS(0.862)PGIPPSAGAHQLFR;T(0.213)PKDS(0.575)PGIPPS(0.213)AGAHQLFR 112.12 0.00025068 40285000.0 5209.9 5901.0 7109.5 7715.299999999999 7602.6 6951.5 9034.5 8488.8 3170.0 4321.6 True False 5331.28053329931 5210.108176699527 6144.068949688115 6367.967689117912 6914.94617234805 6881.574221456996 8353.02039128232 8263.64944849154 5379.258472360472 4876.319455948742 1.0933000968169857 1.0684509544065222 1.2599808124122824 1.3058963315763639 1.4180666863226807 1.4112230102279282 1.7129764501159301 1.6946489095193529 1.103139062351254 1.0 12.251576927112474 -5.654534877046027 1.2793432655139085 1.4438589181280015 1.061264440146173 0.2133409683279045 0.21339659602719482 0.6458789009651522 2.0242723971027194 0.07194089889941399 0.21375268888475948 2.2154661709153513e-06 5.654534877046027 -0.38259447798182844 TPKDS(ph)PGIPPSAGAHQLFR ddPTM_A459_Selumetinib_30min_R2 3 TPKDSPGIPPSAGAHQLFR 19 1 E9PGT3;Q15418-3;Q15418-4;Q15418;Q15418-2;Q5SVM6 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 T(0.231)PKDS(0.769)PGIPPSAGAHQLFR;T(0.242)PKDS(0.758)PGIPPSAGAHQLFR;T(0.183)PKDS(0.816)PGIPPSAGAHQLFR 117.53 0.00019632 34660700.0 236385.0 219840.0 299470.0 334535.0 320661.0 228592.0 253149.0 306018.0 264850.0 437901.0 True False 223247.66802412993 236701.02110298644 280202.4262382825 288970.7558949369 280376.6984342878 260078.47304842985 264920.9301052269 306908.46171599266 317827.400527301 425257.6603265642 0.5249703623273791 0.556606131259855 0.6589003617785727 0.6795192252928031 0.659310165556996 0.6115785729731715 0.6229656860308843 0.7217000194195473 0.7473760737977883 1.0 18.69797769836923 -14.522878745162481 0.13753916637724048 2.2664933533272635 0.5063495676589505 0.8921361681975416 0.04111464517685024 47.890470604997304 0.4050741543242659 16.497439976844454 0.3032052040941393 3.0000000008141213e-15 14.522878745162481 -1.760143785668313 TPKDS(ph)PGLPASANAHQLFK ddPTM_A459_Selumetinib_30min_R2 1 TPKDSPGLPASANAHQLFK 19 1 Q9UK32-2;Q9UK32 Q9UK32-2 RPS6KA6 Ribosomal protein S6 kinase alpha-6 1 T(0.445)PKDS(0.555)PGLPASANAHQLFK 73.346 0.0048446 3773500.0 42694.0 53184.0 53732.0 52453.0 56025.0 44361.0 48447.0 60050.0 42343.0 86714.0 True False 40321.23839762339 57263.04178648667 50274.94161897821 45308.810913528025 48986.63863014518 50471.325080936316 50699.88149590928 60224.73555818732 50812.783162271044 84210.34150997053 0.47881575676604216 0.6800001135217663 0.597016241918763 0.5380433103713687 0.5817176103524666 0.5993483006473794 0.6020624140314927 0.7151703042441253 0.60340312426182 1.0 16.361709794895795 -14.52287874528025 0.23410877908150715 3.212386954090409 0.5603880376755979 0.8238600923680969 0.05675909134073955 63.465028411947124 0.6330338937238593 66.52880137307511 0.09159165994279538 3.0000000000006025e-15 14.52287874528025 -2.651998916414811 TPLALAGS(ph)PTPK ddPTM_A459_Selumetinib_30min_R1 2 TPLALAGSPTPK 12 0 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 TPLALAGS(0.973)PT(0.027)PK;TPLALAGS(0.976)PT(0.024)PK 171.73 0.00025356 64137000.0 7685.9 7987.9 8637.1 8246.1 7434.200000000001 7021.200000000001 7367.7 7169.5 4046.8 6964.8 True False 7864.966515841988 7052.6729545260405 7464.229260194275 6806.073433467945 6761.777922614611 6950.573102739531 6811.948457230702 6979.341570181899 6867.124033422197 7858.7999228970275 1.0007846736149872 0.897423655484307 0.9497925043805798 0.8660448796562553 0.8604084579012904 0.884431868851715 0.8667924522908048 0.8880925381300547 0.8738133176561054 1.0 12.940093307391408 -1.522880299197383 0.9597250158969373 0.8875979576510712 83.43235678756602 0.32442385551518704 0.04252623565439463 1314.2612908386225 2.1613866788619847 0.012726118709477041 238261.16922542767 0.02999989265940529 1.522880299197383 82.54475882991495 TPLALAGS(ph)PTPK ddPTM_A459_Selumetinib_30min_R2 1 TPLALAGSPTPK 12 0 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 TPLALAGS(0.983)PT(0.017)PK 142.1 0.00093644 19793000.0 173650.0 149490.0 160580.0 150880.0 144450.0 117160.0 143210.0 133920.0 110970.0 146570.0 True False 163999.22817602716 160955.4023138895 150248.4576262845 130329.88371748266 126302.89960061535 133297.72652741143 149869.54876523145 134309.6850283504 133167.10076086313 142338.14326540555 1.152180465570863 1.1307959948147557 1.055574101076542 0.9156356878596335 0.8873440154766479 0.9364863378810749 1.0529120678902122 0.94359587632048 0.9355686234613727 1.0 17.118962796356968 -5.512643728348173 3.0685533376801786 0.951777165187832 1.1398589691647774 0.7491489880103268 0.044040659672463046 0.13022325154720135 2.4860451624089754 0.013328352398911638 0.028778621796449026 3.071540680630772e-06 5.512643728348173 0.1880818039769454 TPLDLFAHFGPEPGDHSDPLPPSAPS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 3 TPLDLFAHFGPEPGDHSDPLPPSAPSPTR 29 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 TPLDLFAHFGPEPGDHSDPLPPS(0.015)APS(0.714)PT(0.271)R;TPLDLFAHFGPEPGDHSDPLPPS(0.11)APS(0.628)PT(0.262)R;TPLDLFAHFGPEPGDHSDPLPPS(0.02)APS(0.726)PT(0.254)R 124.39 8.6064e-14 71176000.0 4747.52 6756.18 4295.1900000000005 4315.469999999999 5502.3 5006.63 5831.74 5355.68 2839.3199999999997 5098.0599999999995 True False 4858.127978934172 5965.163304737131 3711.9267897898417 3561.854175904722 5004.617936509964 4956.267847856324 5391.847156639193 5213.629968699601 4818.118664272092 5752.445660309612 0.8445326154845753 1.0369786447345717 0.6452780276398222 0.6191895388913614 0.8699982984699072 0.8615931623749687 0.9373138791803882 0.9063327628928857 0.8375774320678707 1.0 12.48995973495463 -6.505111571808257 24.382920509869223 0.9002050242997488 0.7880863132676952 0.20129276540139984 0.11438559751718701 1059.889924407697 1454550.1819109924 0.038786818346860624 0.04305084718899054 3.1252763692863166e-07 6.505111571808257 -0.11211871103205362 TPLDLFAHFGPEPGDHSDPLPPSAPS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 TPLDLFAHFGPEPGDHSDPLPPSAPSPTR 29 0 Q8N1G0;Q8N1G0-2;F8WCX2 Q8N1G0 ZNF687 Zinc finger protein 687 1 TPLDLFAHFGPEPGDHSDPLPPS(0.007)APS(0.722)PT(0.271)R 100.63 5.2332e-08 43379000.0 25889.0 27534.0 31009.0 34193.0 47696.0 28794.0 26799.0 33891.0 43442.0 28302.0 True False 24450.19302187832 29645.76926423594 29013.914700046444 29535.854413784968 41704.002072349955 32760.112134092542 28045.206601211066 33989.61719904293 52131.61387089667 27484.847722572933 0.8895880839025972 1.0786222853943 1.0556330889262198 1.0746231782658766 1.5173452111979149 1.1919335506154944 1.0203879200748824 1.236667473734181 1.8967401383156175 1.0 14.746348865819886 -5.252352622829026 0.601593479866447 1.3208961165946862 0.7853471570858208 0.22345101356306318 0.2503853750992572 3.7312647496672646 1.5055063860375044 0.14133668313627298 1.2847634668631245 5.593032940912425e-06 5.252352622829026 -0.5355489595088654 TPLGAS(ph)LDEQSSSTLK ddPTM_A459_Selumetinib_30min_R1 4 TPLGASLDEQSSSTLK 16 0 E9PHV5;P28290-3;P28290 E9PHV5 SSFA2 Sperm-specific antigen 2 1 TPLGAS(1)LDEQSSSTLK;T(0.01)PLGAS(0.99)LDEQSSSTLK;TPLGAS(1)LDEQSSSTLK;TPLGAS(1)LDEQSSSTLK 243.01 1.0062e-21 92075000.0 8423.0 7545.0 9443.7 10234.099999999999 8033.6 6881.5 9569.4 9827.5 2441.94 6030.6 True False 8619.239511695057 6661.6278924246635 8161.297410530927 8446.90655284975 7306.962298447283 6812.278357902079 8847.572453631858 9566.842775781106 4143.793827758968 6804.686253018439 1.2666622958364486 0.9789764942461061 1.199364247971127 1.2413366669334462 1.0738132555642874 1.001115717110436 1.3002175448878677 1.4059197470768654 0.6089617762936321 1.0 12.732312928882275 -8.264953249676893 24.998255312005057 0.804480900020047 1.173234727156979 0.49026664480947024 0.1542782140526523 271.47074949022885 1931241.8721223958 0.12903133423097501 0.03849117316473963 5.43308813689629e-09 8.264953249676893 0.36875382713693194 TPLGAS(ph)LDEQSSSTLK ddPTM_A459_Selumetinib_30min_R2 3 TPLGASLDEQSSSTLK 16 0 E9PHV5;P28290-3;P28290 E9PHV5 SSFA2 Sperm-specific antigen 2 1 T(0.176)PLGAS(0.822)LDEQS(0.002)SSTLK;TPLGAS(1)LDEQSSSTLK;TPLGAS(0.654)LDEQS(0.164)S(0.164)S(0.017)T(0.002)LK 120.08 0.0016327000000000002 69267600.0 169512.0 186402.0 204344.0 207878.0 174499.0 161210.0 119974.0 138041.0 145202.0 217350.0 True False 160091.20165030097 200698.4340231024 191196.729512925 179564.65779044852 152576.87557914713 183415.21418132438 125553.02872397105 138442.6764560823 174246.4572828583 211074.54075688068 0.7584581308396486 0.9508415051072897 0.9058256331025195 0.8507167996033884 0.7228577877371191 0.8689594373799217 0.59482791374913 0.6558947183286447 0.8255209588898662 1.0 17.687393049621946 -6.128215761405066 4.60659027069233 0.7564748806542463 0.8794729806581432 0.10615352180252702 0.11605250746762827 0.38632324928547646 12.767503143155691 0.034110767448029 0.04489740504067157 7.443620762543751e-07 6.128215761405066 0.12299810000389688 TPLLSSLSATS(ph)NNSTVACIDR ddPTM_A459_Selumetinib_30min_R1 1 TPLLSSLSATSNNSTVACIDR 21 0 P00533;E9PFD7;Q504U8 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 TPLLSSLSAT(0.027)S(0.544)NNS(0.264)T(0.166)VACIDR 148.85 1.4688e-06 0.0 778.87 650.63 806.22 480.63 588.8 765.71 610.69 796.74 333.21 528.89 True False 797.0161555828003 574.4539371303189 696.7397522494616 396.69699304249275 535.543143961083 758.0076526090542 564.6251616306606 775.6078670237429 565.43303330449 596.7781833248634 1.3355316562384032 0.9625920537675016 1.167502049702415 0.6647310577480443 0.897390620041406 1.2701664936642356 0.9461223238506024 1.2996585476743732 0.9474760457131015 1.0 9.221050985112614 -6.733830142369767 24.99968203972715 1.102253479287421 0.9932260312146661 0.04340182373427759 0.197871046952888 674.6017819710268 610838.6160546308 0.06498381053700958 0.06496954506872038 1.8457371673322282e-07 6.733830142369767 -0.10902744807275488 TPLLSSLSATS(ph)NNSTVACIDR ddPTM_A459_Selumetinib_30min_R2 1 TPLLSSLSATSNNSTVACIDR 21 0 P00533;E9PFD7;Q504U8 P00533 EGFR Epidermal growth factor receptor;Receptor protein-tyrosine kinase 1 TPLLSSLSAT(0.009)S(0.974)NNS(0.013)T(0.004)VACIDR 176.46 4.0094e-12 0.0 7691.0 4412.2 4893.5 6983.5 5129.8 3025.3 12188.0 7301.2 5653.2 6701.7 True False 7263.565009512382 4750.601552540924 4578.657537639953 6032.335252790555 4485.348663006136 3442.0076140609203 12754.766150063828 7322.445283221274 6783.997963605567 6508.2045078922665 1.1160628097510024 0.729940423165873 0.7035208454324967 0.9268816377044327 0.6891837307151173 0.5288720736859023 1.9597979956832303 1.1251098938795803 1.0423762737293911 1.0 12.668043870320096 -7.221941465452139 24.999998436695616 1.2922479737987291 0.7787686938277365 0.4171524399501646 0.2890724217724686 505.9266603823352 320224.03727619036 0.10896561896054247 0.0844031148537099 5.998719220111069e-08 7.221941465452139 -0.5134792799709926 TPLSPS(ph)PMK ddPTM_A459_Selumetinib_30min_R2 1 TPLSPSPMK 9 0 F8WAN1;Q69YQ0-2;Q69YQ0;A0A494C1J1 F8WAN1 SPECC1L-ADORA2A;SPECC1L Cytospin-A 1 TPLS(0.469)PS(0.531)PMK 90.434 0.028549 5294000.0 45666.0 42325.0 47915.0 46686.0 53618.0 44468.0 48006.0 50597.0 32506.0 41095.0 True False 43128.06653548203 45571.19140367495 44832.20106590747 40327.286262157904 46882.02748899823 50593.063359687025 50238.374122084395 50744.22889321571 39008.10829352626 39908.48057236714 1.0806742305630186 1.1418924186061021 1.1233752932440517 1.0104941527160207 1.1747384720394396 1.2677271255152207 1.2588395599523208 1.2715149302965774 0.9774390739530109 1.0 15.284407732003256 -6.482169363019648 23.8080142418294 1.183299013895531 1.0949879812193344 0.06735536728192049 0.1034134070847138 590.5508902724806 345370.5605638254 0.031803019011819963 0.03605525114179277 3.294811984269046e-07 6.482169363019648 -0.08831103267619667 TPLSQS(ph)MSVLPTSKPEK ddPTM_A459_Selumetinib_30min_R1 1 TPLSQSMSVLPTSKPEK 17 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 T(0.176)PLS(0.215)QS(0.567)MS(0.043)VLPTSKPEK 80.994 0.0087825 62116000.0 1565.2 1911.8 1373.5 1360.1 1135.3 1294.8 1231.8 1231.4 1084.9 1239.7 True False 1601.666114650969 1687.9655672282927 1186.9862440954525 1122.584067239029 1032.6123154534948 1281.775487584337 1138.8843342721298 1198.7392718490821 1840.9960620390773 1398.8275707005862 1.1450061095441473 1.2067002413906491 0.8485579416346252 0.8025178304691236 0.7381984292290744 0.9163212925109668 0.8141706369868968 0.8569599977563409 1.3160993539161059 1.0 10.450002421413025 -5.259751230124725 24.92560652541373 0.8930944480518284 1.175853198714229 0.31727236747134935 0.15314032670816297 152.56386821463693 2252562.211018907 0.03984387791789525 0.09478733850290856 5.498557486310471e-06 5.259751230124725 0.28275875066240075 TPLSQS(ph)MSVLPTSKPEK ddPTM_A459_Selumetinib_30min_R2 1 TPLSQSMSVLPTSKPEK 17 1 Q6WKZ4;E7EX40;Q6WKZ4-2;Q6WKZ4-3 Q6WKZ4 RAB11FIP1 Rab11 family-interacting protein 1 1 T(0.069)PLS(0.069)QS(0.857)MS(0.005)VLPTSKPEK 76.156 0.011717 13906000.0 76214.0 40387.0 59654.0 64294.0 49814.0 81223.0 46606.0 55362.0 43489.0 50258.0 True False 71978.33098881503 43484.5530353271 55815.9265863643 55537.04628666368 43555.91997718972 92410.73098101694 48773.27134803698 55523.0942543275 52188.015184186384 48806.920954033994 1.4747566447923175 0.8909505493346024 1.1436067978746567 1.137892848003423 0.8924127792902644 1.8933939936110433 0.9993105566723066 1.1376069862431755 1.0692748930697078 1.0 15.57479811992146 TPLYLQPDAYGS(ph)LDR ddPTM_A459_Selumetinib_30min_R1 4 TPLYLQPDAYGSLDR 15 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 TPLYLQPDAYGS(1)LDR;TPLYLQPDAYGS(1)LDR;TPLYLQPDAYGS(1)LDR;TPLYLQPDAYGS(1)LDR 140.28 0.00039016 39902400.0 7086.1 6873.7 7031.200000000001 8100.000000000001 7214.799999999999 5818.6 6333.0 6320.2 3922.12 6054.799999999999 True False 7251.192342849624 6068.924008503565 6076.401659616998 6685.487055831286 6562.222613876394 5760.070166866098 5855.29671127245 6152.567765097093 6655.551179689103 6831.9925587463995 1.0613583490465837 0.8883095167798529 0.8894040219405559 0.9785559627509319 0.9605137238440573 0.8431025235078727 0.8570408502240577 0.9005524687260529 0.9741742430864604 1.0 12.738090688270152 -4.754809712038605 24.99377651694107 0.9157540441802838 1.06135859596634 0.39283614845458625 0.051828479443153955 237.37986976669188 894838.4915045972 0.013300806843002298 0.12522965817073076 1.7586940243813255e-05 4.754809712038605 0.14560455178605625 TPLYLQPDAYGS(ph)LDR ddPTM_A459_Selumetinib_30min_R2 1 TPLYLQPDAYGSLDR 15 0 Q8WUF5 Q8WUF5 PPP1R13L RelA-associated inhibitor 1 TPLYLQPDAYGS(1)LDR 85.176 0.020988 4063300.0 10661.0 7226.9 8985.8 10642.0 14337.0 7337.4 8587.3 9204.9 5442.7 9133.9 True False 10068.504299364386 7781.179991853948 8407.663410999303 9192.541241526033 12535.857885593792 8348.06024771448 8986.626465412133 9231.684735046774 6531.392081744146 8870.180574277754 1.135095753130618 0.8772290402315202 0.9478570746778612 1.036342063676029 1.4132584766026042 0.9411375763783945 1.0131277926260098 1.0407549945282208 0.7363313550441399 1.0 13.114747759082825 -8.158473009057767 9.128631036562004 0.8687117865016792 1.048537530861376 0.18953014758999698 0.1509040270968565 0.5688126012593779 45.5243698796775 0.10474838556978953 0.039445127512437554 6.942677483788387e-09 8.158473009057767 0.17982574435969678 TPMYGS(ph)QTPMYGSGSR ddPTM_A459_Selumetinib_30min_R2 1 TPMYGSQTPMYGSGSR 16 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 T(0.003)PMY(0.004)GS(0.566)QT(0.424)PMY(0.001)GS(0.002)GS(0.001)R 87.669 0.014547999999999997 4571200.0 9476.8 10549.0 10084.0 11199.0 8521.1 11008.0 10115.0 8564.1 9422.5 8665.1 True False 8950.117394636192 11358.074379618822 9435.20641862905 9673.676880647447 7450.603238399468 12524.252079325233 10585.36754249226 8589.020113136927 11307.263286647109 8414.916048366431 1.0636015075128002 1.349754924985109 1.1212478371023897 1.1495868556556041 0.8854043457564662 1.4883395160854325 1.2579290728096062 1.0206899348454337 1.3437167075293832 1.0 13.038733163203695 -10.72259777197639 4.365134361274773 0.9999438128789964 1.1856989586507722 0.0986744890704504 0.16925221315222688 9.580655062423846e-05 1.756502635434555e-05 0.15985062081555917 0.038757038895562826 1.8940970515135324e-11 10.72259777197639 0.18575514577177588 TPMYGSQT(ph)PLQDGSR ddPTM_A459_Selumetinib_30min_R1 1 TPMYGSQTPLQDGSR 15 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 TPMYGS(0.016)QT(0.983)PLQDGS(0.001)R 120.54 0.0041613 4236900.0 578.59 976.5 684.63 681.51 709.51 588.32 902.01 879.77 330.26 500.3 True False 592.0700212598413 862.1709260374656 591.6610064034002 562.4970720271084 645.3349457741647 582.4020349518207 833.9706594875823 856.4356417042927 560.4270987639655 564.5183783346802 1.0488055730026682 1.527268126470666 1.0480810352867347 0.9964194145219247 1.1431602061883124 1.031679494066955 1.477313567625171 1.5171085204183496 0.9927526193517671 1.0 9.140876739596209 -7.241181806567559 24.99036506295827 1.2898860957050928 1.1409622963329755 0.048704902672602635 0.21407325043325431 2015.0163617941014 2485790.001210936 0.08226825123311471 0.06365472746969325 5.7387617294942846e-08 7.241181806567559 -0.1489237993721173 TPNTEQQTPLFQVIS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 1 TPNTEQQTPLFQVISPQR 18 0 Q8IZD4;Q8IZD4-2 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 TPNTEQQTPLFQVIS(1)PQR 214.3 3.4007e-12 5152300.0 1229.6 1416.7 1269.8 1330.1 1245.4 1281.8 1427.2 1538.1 715.1 1172.1 True False 1258.2472876148922 1250.832105394039 1097.368134512127 1097.8230040692824 1132.7537898932292 1268.906255781281 1319.5451549546885 1497.3045915470777 1213.4724711624524 1322.5504522208257 0.9513794241286178 0.9457726949422932 0.8297363118884631 0.830080245502785 0.8564919304145334 0.9594388279483287 0.997727650192028 1.1321341949812236 0.9175245217487094 1.0 10.369107043508336 -7.028244533408338 2.8069937614902503 1.0225635406509153 0.8807898331815728 0.4813592621173912 0.06281027815478522 0.23116718290841115 3.6523757766410507 0.026451110655924714 0.02089685330132604 9.370342528101349e-08 7.028244533408338 -0.14177370746934248 TPNTEQQTPLFQVIS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 3 TPNTEQQTPLFQVISPQR 18 0 Q8IZD4;Q8IZD4-2 Q8IZD4 DCP1B mRNA-decapping enzyme 1B 1 TPNTEQQTPLFQVIS(1)PQR;TPNTEQQTPLFQVIS(1)PQR;TPNTEQQTPLFQVIS(1)PQR 204.94 1.3065999999999995e-29 9050500.0 47750.0 39505.7 51879.0 55344.0 60678.0 45772.0 44680.0 62074.0 46247.0 46713.0 True False 45096.24615839501 42535.66015915323 48541.16162158435 47806.051726274825 53055.087171797415 52076.67752315361 46757.70853174043 62254.62506309614 55497.69224914501 45364.27431505017 0.994091646770458 0.9376466570091586 1.0700305990672534 1.0538259996019503 1.1695345725875685 1.1479667273301122 1.0307165547719996 1.3723271451615038 1.2233788170779347 1.0 15.4692689599223 -5.84021026626542 0.8232806795833765 1.183098140420885 0.9462145595690281 0.34039335789538605 0.10010558864704285 0.8632131961190498 1.091582859936999 0.04702744272228066 0.14213773955725534 1.4447401218373434e-06 5.84021026626542 -0.2368835808518568 TPPDTTFPEPTCLS(ph)ASPPNAPPR ddPTM_A459_Selumetinib_30min_R2 1 TPPDTTFPEPTCLSASPPNAPPR 23 0 H0Y8W5;A1A4S6 H0Y8W5 ARHGAP10 Rho GTPase-activating protein 10 1 TPPDTTFPEPT(0.045)CLS(0.51)AS(0.445)PPNAPPR 76.294 0.00056395 2063900.0 7932.2 5747.5 8642.8 9476.7 8594.2 6558.4 4035.4 5919.6 5832.9 7176.7 True False 7491.360079112483 6188.314768874697 8086.731657569137 8185.957111780662 7514.519762877177 7461.760068772399 4223.054095993402 5936.825055957464 6999.642984843087 6969.4900236940575 1.0748792312843884 0.8879150049481939 1.1603046464055207 1.1745417647418968 1.0782022411008827 1.0706321471735778 0.6059344488099354 0.851830626885775 1.0043264228869715 1.0 12.766837378746468 -7.068184539620459 24.99967201456552 0.8510475628919827 1.074957183614966 0.3967843459472039 0.1256816934577953 177.816655450593 65195.16691594892 0.04897918295146686 0.037939121293039085 8.547034566765537e-08 7.068184539620459 0.22390962072298337 TPPGALLGAPPPLVPAPRPS(ph)SPPR ddPTM_A459_Selumetinib_30min_R1 1 TPPGALLGAPPPLVPAPRPSSPPR 24 1 J3KNZ9;Q9HAH7 J3KNZ9 FBRS Probable fibrosin-1 1 TPPGALLGAPPPLVPAPRPS(0.5)S(0.5)PPR 62.67 0.0027946 18235000.0 847.54 846.09 1216.2 1331.7 947.51 962.05 959.59 1224.9 489.44 896.04 True False 867.2860329742408 747.0293894634301 1051.0467201084016 1099.1435941050036 861.8078877964775 952.3726504715097 887.2073537296587 1192.4116729640568 830.543932716754 1011.0554621687132 0.8578026284670011 0.7388609402901128 1.039553970515037 1.0871249256171776 0.8523843844806498 0.9419588599310577 0.8775061180388657 1.179373157637005 0.8214622874745544 1.0 9.981646424139493 -5.260700968936004 24.999528536231704 0.9763013780281046 0.7983317789760016 0.30173575416198906 0.1074367600121182 74.7716024959235 2531338.578603278 0.02698234133718183 0.06339079460304863 5.48654607990346e-06 5.260700968936004 -0.17796959905210297 TPPGALLGAPPPLVPAPRPS(ph)SPPR ddPTM_A459_Selumetinib_30min_R2 2 TPPGALLGAPPPLVPAPRPSSPPR 24 1 J3KNZ9;Q9HAH7 J3KNZ9 FBRS Probable fibrosin-1 1 TPPGALLGAPPPLVPAPRPS(0.5)S(0.5)PPR;TPPGALLGAPPPLVPAPRPS(0.5)S(0.5)PPR 101.73 2.1824e-06 20477300.0 52922.0 54029.0 46565.0 49378.0 43886.0 35900.0 42787.0 45604.0 33717.0 41362.0 True False 49980.80710355147 58172.850569383445 43569.05859613862 42652.63121819889 38372.6483341821 40844.8991322471 44776.68028083204 45736.700089851365 40461.34213169339 40167.771588617834 1.2443012177881014 1.4482468971683664 1.0846770152538059 1.061862023490623 0.9553093641135818 1.016857483421389 1.1147414583865094 1.1386417090364946 1.0073086091526855 1.0 15.293750805901054 -5.351362537919814 5.827955316825109 1.048739324203322 1.3446094752163986 0.7498616936702296 0.06919656156692656 0.10006492404110721 5.1281359227100625 0.018435665747921996 0.039282582314839526 4.45284381199974e-06 5.351362537919814 0.29587015101307657 TPPGALLGAPPPLVPAPRPS(ph)SPPRGPGPAR ddPTM_A459_Selumetinib_30min_R1 1 TPPGALLGAPPPLVPAPRPSSPPRGPGPAR 30 2 J3KNZ9;Q9HAH7 J3KNZ9 FBRS Probable fibrosin-1 1 TPPGALLGAPPPLVPAPRPS(0.5)S(0.5)PPRGPGPAR 52.465 0.004489 13218000.0 1670.2 1678.3 2567.6 2671.9 1916.7 1958.4 1901.4 1619.8 1042.2 1558.8 True False 1709.112410356534 1481.803855779497 2218.9340228172437 2205.302822774768 1743.3348234208686 1938.7002740849289 1757.9758671740774 1576.8376421480768 1768.5372807236859 1758.8871639978008 0.9717009967096848 0.8424666949137789 1.2615556405413724 1.2538057403081517 0.991157852024127 1.1022311799003799 0.9994818901164461 0.896497327642132 1.0054864899371663 1.0 10.780447218772544 -7.444567977836991 4.9040276261417075 0.9603497134206145 1.0729428811089319 0.13120113707545122 0.12124257173463338 0.46983978309115604 20.199041604457104 0.05776789547651298 0.03754189677142874 3.592791562723985e-08 7.444567977836991 0.1125931676883174 TPPGPCCS(ph)PGVGWAQR ddPTM_A459_Selumetinib_30min_R1 1 TPPGPCCSPGVGWAQR 16 0 H3BSW6;Q2VPK5-3;Q2VPK5;Q2VPK5-5 H3BSW6 CTU2 Cytoplasmic tRNA 2-thiolation protein 2 1 T(0.329)PPGPCCS(0.671)PGVGWAQR 131.61 0.0006886 7032000.0 141.28 345.18 331.03 405.91 242.16 286.33 324.28 442.03 198.41 319.95 True False 144.5715491169747 304.76616513017177 286.07794421763225 335.0254383743798 220.25667075682045 283.4497801668392 299.819298520674 430.30592848420474 336.6872787069531 361.0186990769157 0.40045446257112977 0.8441838772047671 0.7924186335752177 0.9280002371927056 0.6100976800370508 0.7851387778294822 0.8304813553626953 1.1919214422534032 0.932603434580604 1.0 8.495929753665234 -7.586876019589009 5.5649857965827225 1.0455261773449898 0.7438548485964112 0.47040432001446153 0.14851606337083056 0.1806388428967274 10.80050190952326 0.0699700670038714 0.03984605202420366 2.5889518918646665e-08 7.586876019589009 -0.3016713287485786 TPPGPCCS(ph)PGVGWAQR ddPTM_A459_Selumetinib_30min_R2 1 TPPGPCCSPGVGWAQR 16 0 H3BSW6;Q2VPK5-3;Q2VPK5;Q2VPK5-5 H3BSW6 CTU2 Cytoplasmic tRNA 2-thiolation protein 2 1 T(0.391)PPGPCCS(0.609)PGVGWAQR 88.10799999999998 0.014202 20120000.0 7630.5 6268.5 5748.4 4479.8 5998.5 2003.6 4368.0 1698.1 4803.5 2163.8 True False 7206.427357311694 6749.273793595661 5378.554202384696 3869.64351191396 5244.914802729601 2279.5777131300906 4571.120655027799 1703.0411898644122 5764.334221003919 2101.3254717724312 3.429467473800334 3.2119126162320617 2.5596007256543554 1.8415250583004563 2.496003057682258 1.0848284779069979 2.1753510897919774 0.8104604511494009 2.7431896193319374 1.0 11.037083921278299 -5.249009861322859 0.7052178665988624 1.594368251110208 4.087367152012142 0.5477838408405753 0.5919699704326151 1.2907280031985182 0.7410213853402633 0.25558198001522975 2.3256476243202164 5.636248577130888e-06 5.249009861322859 2.492998900901934 TPPNLLSTLQYPRPSS(ph)GTLASASPDWVGPSTR ddPTM_A459_Selumetinib_30min_R1 1 TPPNLLSTLQYPRPSSGTLASASPDWVGPSTR 32 1 A0A3B3ITG3;Q5VWQ8-2;Q5VWQ8;H0Y3A3;Q5VWQ8-3;Q5VWQ8-4;Q5VWQ8-5 A0A3B3ITG3 DAB2IP Disabled homolog 2-interacting protein 1 T(0.002)PPNLLS(0.007)T(0.007)LQY(0.013)PRPS(0.175)S(0.533)GT(0.218)LAS(0.039)AS(0.006)PDWVGPSTR 50.07100000000001 0.0060625 10567000.0 237.44 191.48 254.14 269.04 339.99 320.86 209.95 289.39 0.0 203.44 True False 242.9718900221863 169.06143258336303 219.6291838910946 222.05721450627772 309.23796453010976 317.6324397175705 194.1133024682852 281.71443712880125 0.0 229.55350567341074 1.058454277617812 0.7364794194164445 0.9567668472184624 0.9673440353474797 1.347128041555886 1.3836967498526074 0.845612450565025 1.2272277711567632 0.0 1.0 7.842686654406251 -8.237650333391604 24.988009440141028 0.49999971035710067 1.0601718920207706 0.36610605937835417 0.297497096592823 701.5720885073792 736933.7347865769 0.19597148486223243 0.07397978775955337 5.785616814168747e-09 8.237650333391604 0.5601721816636699 TPPPPT(ph)LSPAAITVGR ddPTM_A459_Selumetinib_30min_R2 1 TPPPPTLSPAAITVGR 16 0 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 T(0.238)PPPPT(0.583)LS(0.179)PAAITVGR 147.53 0.00073561 6305000.0 1943.7 2206.3 1950.6 2288.0 1620.2 1249.5 1957.5 0.0 1825.7 3865.1 True False 1835.6769352475917 2375.516115627361 1825.1005196526999 1976.3704529798501 1416.655991228224 1421.6072831683218 2048.5276287126635 0.0 2190.8910143201538 3753.504520264175 0.48905680686869 0.6328795137457754 0.48623906266782585 0.5265400487224541 0.3774222153137352 0.3787413270700598 0.5457639967271136 0.0 0.583692120921159 1.0 11.874022505066405 -8.5410480210393 24.215847323887953 1.0000000092178407 0.4325377265717352 0.5319953861186837 0.1615216250356343 2108.886912185537 2810702.491064756 0.15777151146714552 0.04073642915878007 2.8770802711046107e-09 8.5410480210393 -0.5674622826461055 TPPPPTLS(ph)PAAITVGR ddPTM_A459_Selumetinib_30min_R2 1 TPPPPTLSPAAITVGR 16 0 Q8NDX5-2;Q8NDX5;Q8NDX5-7;E7EX82;H7C4H9 Q8NDX5-2 PHC3 Polyhomeotic-like protein 3 1 T(0.017)PPPPT(0.121)LS(0.861)PAAITVGR 142.4 0.00039446 6321100.0 1315.7 2644.6 1067.4 1496.4 1411.0 2424.4 1390.3 2839.7 859.88 1555.6 True False 1242.5786611644055 2847.432316270731 998.7246460972484 1292.5877385660172 1233.7375654999537 2758.3390934880176 1454.9517048271869 2847.963056862358 1031.8800270546155 1510.6857860658067 0.8225262146673019 1.8848607318177908 0.6611068001759455 0.8556297745623397 0.8166738423566601 1.8258853819439207 0.9631067679641278 1.8852120560948327 0.6830540384853174 1.0 10.56098790411598 TPPRDLPT(ph)IPGVTSPSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R1 3 TPPRDLPTIPGVTSPSSDEPPMEASQSHLR 30 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 T(0.454)PPRDLPT(0.541)IPGVT(0.004)S(0.001)PSSDEPPMEASQSHLR;T(0.179)PPRDLPT(0.764)IPGVT(0.019)S(0.019)PS(0.014)S(0.005)DEPPMEASQSHLR;T(0.198)PPRDLPT(0.76)IPGVT(0.032)S(0.009)PS(0.002)SDEPPMEASQSHLR 118.85 1.4317e-15 155021000.0 5177.62 5789.58 4714.67 5021.5 6829.87 4512.37 6501.93 5162.24 1933.33 4501.09 True False 5298.248472105256 5111.733282097279 4074.443709828548 4144.589290229237 6212.109464411483 4466.979654704152 6011.484185366123 5025.320625881273 3280.719805163618 5078.848745829394 1.0431987123963924 1.0064748012617797 0.802237655369116 0.8160489704743926 1.2231333861857356 0.879526026123993 1.1836312688584363 0.9894605800198172 0.6459573752531322 1.0 12.310285794078277 -8.076234766396857 24.9930303225321 0.8212208411862463 0.9915456663255523 0.16417126196861254 0.15339000950278248 223.97318883814847 73425.29561898144 0.10216697668646961 0.03861549719434536 8.390063225949637e-09 8.076234766396857 0.17032482513930602 TPPRDLPT(ph)IPGVTSPSSDEPPMEASQSHLR ddPTM_A459_Selumetinib_30min_R2 2 TPPRDLPTIPGVTSPSSDEPPMEASQSHLR 30 1 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 1 T(0.434)PPRDLPT(0.562)IPGVT(0.003)SPSSDEPPMEASQSHLR;T(0.152)PPRDLPT(0.646)IPGVT(0.051)S(0.051)PS(0.051)S(0.051)DEPPMEASQSHLR 79.163 1.5466e-05 44113000.0 17071.4 13801.9 21040.7 24558.0 23805.0 20067.2 16136.400000000001 19680.7 17970.0 21441.0 True False 16122.639930228805 14860.46134989678 19686.964269382028 21213.15803508706 20814.403080599845 22831.274648095514 16886.77457367 19737.967578684722 21564.502123751503 20821.942619591762 0.77431007398218 0.7136923591324418 0.9454912362911897 1.0187886126977987 0.9996379041509401 1.0965006995367057 0.8110086019438414 0.94794073441125 1.0356623547440311 1.0 14.345817053225694 -5.3294308054022235 4.732083783212992 0.9821910002330583 0.7436532644346836 0.6427927575548535 0.07124140438996372 0.1260994011364438 5.484331937339188 0.01947564358676293 0.04335925095453817 4.683485657434619e-06 5.3294308054022235 -0.23853773579837467 TPPS(ph)PSGQPEEPGMVR ddPTM_A459_Selumetinib_30min_R2 1 TPPSPSGQPEEPGMVR 16 0 M0R0S1;M0R2P6;Q8TBC3;M0QXA4;Q8TBC3-2 M0R0S1 SHKBP1 SH3KBP1-binding protein 1 1 T(0.036)PPS(0.788)PS(0.176)GQPEEPGMVR 97.214 0.013455000000000002 0.0 6757.9 5061.1 5156.1 7664.5 10294.0 4026.5 5849.3 6216.4 8035.1 6873.5 True False 6382.32297201713 5449.2700959985605 4824.362139537214 6620.581878000031 9000.775690472368 4581.113826072225 6121.3040401680655 6234.488694819576 9642.344519452188 6675.044195502265 0.9561469235391169 0.8163646466446398 0.7227460969903291 0.9918409053322925 1.3484218870846147 0.6863046433698583 0.9170432226190626 0.9339996129194859 1.4445364310770152 1.0 12.704561673585255 -6.8800376476702105 0.44239093511235467 1.1185990746862893 0.8394657315036802 0.12827461789238825 0.21654130391420393 2.830138836324878 1.1828582667319536 0.22408778021515743 0.30831987652417037 1.3181424678346512e-07 6.8800376476702105 -0.2791333431826091 TPPSTTVGSHS(ph)PPETPVLTR ddPTM_A459_Selumetinib_30min_R1 4 TPPSTTVGSHSPPETPVLTR 20 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;Q9ULU4-2 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 TPPSTTVGS(0.002)HS(0.995)PPET(0.003)PVLTR;TPPS(0.005)T(0.005)T(0.001)VGS(0.027)HS(0.961)PPET(0.002)PVLTR;TPPSTTVGS(0.002)HS(0.998)PPETPVLTR;TPPSTT(0.001)VGS(0.024)HS(0.975)PPETPVLTR 130.72 0.00010849 223685000.0 3771.45 4587.700000000001 4866.2 5053.08 4350.4 4121.02 4979.36 3839.59 2186.72 3205.45 True False 3859.3174470357753 4050.5699512361334 4205.396768123257 4170.6544360592525 3956.9070881255047 4079.56628038678 4603.7628662942625 3737.7516004539666 3710.7041282902496 3616.9007312270637 1.0670233257207669 1.1199007803186083 1.1627072680804655 1.153101714971404 1.0940048904198405 1.1279176796767527 1.2728474482440102 1.0334128244614287 1.0259347446982219 1.0 11.820538287264087 -7.965581117340462 24.998732720812956 1.0185359455650904 1.1413001236006017 0.5439179132066081 0.0516637871292676 132.95332328655817 96565.05927942501 0.02855492394938687 0.01371727201525137 1.0824775115503281e-08 7.965581117340462 0.12276417803551132 TPPSTTVGSHS(ph)PPETPVLTR ddPTM_A459_Selumetinib_30min_R2 3 TPPSTTVGSHSPPETPVLTR 20 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-4;Q9ULU4-21;Q9ULU4-23;Q9ULU4-6;Q9ULU4-3;Q9ULU4-18;Q9ULU4-15;Q9ULU4-2 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 1 TPPSTT(0.003)VGS(0.219)HS(0.778)PPETPVLTR;T(0.001)PPSTTVGS(0.046)HS(0.951)PPET(0.001)PVLTR;TPPSTTVGS(0.053)HS(0.946)PPET(0.001)PVLTR 182.0 1.4486e-16 221480000.0 30798.4 35766.2 38262.6 48113.1 56595.0 28822.2 32732.7 35594.1 34183.4 37418.4 True False 29086.74822376366 38509.352533540885 35800.82597316898 41560.01278027312 49485.03013428058 32792.19642811844 34254.83540861458 35697.672938079544 41021.03516399822 36338.03356732116 0.8004491539113281 1.0597533425191283 0.985216382357154 1.14370560815509 1.3617971385986758 0.9024207753940903 0.9426716870948129 0.98237767522408 1.128873280608351 1.0 15.149192729791986 -4.761113638673716 23.80322873673957 1.057457432291932 0.800448660029569 0.2734252951285331 0.12511439954093265 6.219256660261709 453148.8626815161 0.033003423314156864 0.18710458871548488 1.7333503852402554e-05 4.761113638673716 -0.25700877226236285 TPPTAALSAPPPLISTLGGRPVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 TPPTAALSAPPPLISTLGGRPVSPR 25 1 A0A087WVB5;Q75MD7;A0A2R8Y8C6;Q8WXX7-2;Q8WXX7;A0A2R8Y568;A0A024RDL5;A0A2R8Y522;Q8WXX7-5 A0A087WVB5 AUTS2 Autism susceptibility gene 2 protein 1 TPPTAALSAPPPLIS(0.226)T(0.029)LGGRPVS(0.745)PR;TPPTAALSAPPPLIS(0.001)T(0.004)LGGRPVS(0.995)PR 181.03 6.6082999999999996e-21 51029000.0 2323.3 2743.7 2764.8999999999996 2884.3999999999996 2685.4 2543.1000000000004 2607.8999999999996 2619.1000000000004 1496.39 2260.6 True False 2377.4283696451553 2422.4663284884746 2389.4417665085684 2380.6936868937983 2442.5060441458786 2517.5187229500534 2411.184003367663 2549.6329599642104 2539.264537998577 2550.77003010869 0.9320433992804327 0.9497000121117354 0.9367531131008123 0.933323529284353 0.9575563517350099 0.9869642081543432 0.9452769065445389 0.9995542247513268 0.995489404386007 1.0 11.31671712034207 -7.213570099869907 0.608338071907033 1.0028079021721052 0.9354481530047815 0.7260150791877134 0.01421891907227489 0.4294812702075958 0.3263300667889624 0.012782645849900692 0.009736790211540515 6.115470846129881e-08 7.213570099869907 -0.06735974916732379 TPPTAALSAPPPLISTLGGRPVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TPPTAALSAPPPLISTLGGRPVSPR 25 1 A0A087WVB5;Q75MD7;A0A2R8Y8C6;Q8WXX7-2;Q8WXX7;A0A2R8Y568;A0A024RDL5;A0A2R8Y522;Q8WXX7-5 A0A087WVB5 AUTS2 Autism susceptibility gene 2 protein 1 TPPTAALSAPPPLIS(0.024)T(0.005)LGGRPVS(0.971)PR;TPPTAALSAPPPLIS(0.022)T(0.02)LGGRPVS(0.958)PR 122.47 4.2355e-08 28270000.0 57667.0 53568.0 55095.0 60142.0 52360.0 37543.0 31801.0 37024.0 38503.0 40915.0 True False 54462.09899929144 57676.49335173202 51550.24768290037 51950.55584926317 45782.06869566091 42714.20746857805 33279.809512486034 37131.73371034683 46204.67586370643 39733.677640063295 1.3706785335263691 1.4515770192280681 1.2973943199992763 1.3074691026556688 1.1522232880225276 1.0750126845925156 0.837571840541892 0.934515401436364 1.1628592823010788 1.0 15.278074711045756 -6.403064361735467 1.348680550722919 0.9781300915687817 1.387891948542368 0.8013033922093624 0.08430646796085692 0.18332429291086402 0.6807609162890697 0.035686023550686986 0.04429637186058438 3.953080317198916e-07 6.403064361735467 0.40976185697358625 TPPVAVT(ph)SPITHTAQSALK ddPTM_A459_Selumetinib_30min_R2 1 TPPVAVTSPITHTAQSALK 19 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6;Q8NEY1-5;H0Y6F6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 T(0.002)PPVAVT(0.755)S(0.242)PITHTAQSALK 101.53 0.0015899 3202000.0 19293.0 14014.0 14729.0 20837.0 21920.0 15642.0 15496.0 13187.0 15088.0 17827.0 True False 18220.77229599823 15088.82873788779 13781.352175722659 17998.964654170086 19166.21363271366 17796.543516061527 16216.594704741468 13225.371986774628 18106.02159394339 17312.288189891453 1.0524762582589884 0.8715675578170003 0.7960445219349752 1.0396641077566846 1.1070872563168574 1.0279717690035237 0.9367100713012764 0.7639297498811768 1.045847977768496 1.0 14.079508799923548 -5.787415889969641 24.99902862087063 0.98330546649005 0.9031830397369045 0.11236566307602058 0.10476026409683979 538.9150279810236 518633.9206188491 0.03193301144762778 0.04738088721916662 1.6314888498973466e-06 5.787415889969641 -0.08012242675314551 TPPVAVTS(ph)PITHTAQSALK ddPTM_A459_Selumetinib_30min_R2 1 TPPVAVTSPITHTAQSALK 19 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6;Q8NEY1-5;H0Y6F6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 TPPVAVT(0.166)S(0.834)PITHTAQSALK 115.39 0.0003142 3412700.0 16733.0 13518.0 16448.0 16466.0 17673.0 12387.0 13102.0 13666.0 11730.0 14555.0 True False 15803.04684750627 14554.787132779154 15389.753587228355 14223.302394565651 15452.759741375396 14093.196812009593 13711.268961120468 13705.765797471906 14076.327763584044 14134.75933156841 1.1180273025386378 1.0297159499753674 1.0887878050287745 1.0062642073289136 1.09324533788583 0.9970595523712957 0.9700390816345826 0.9696497461305623 0.9958661080380855 1.0 13.786959698579262 -6.879406779497289 5.78740911521529 0.9817596809585328 1.0626889360830802 0.6235196777348941 0.03132123480871613 0.13618902192254076 6.374597343290459 0.010470829663559172 0.009237478267592436 1.3200586294285866e-07 6.879406779497289 0.0809292551245474 TPQASTYS(ph)YETSDLCYTAEKK ddPTM_A459_Selumetinib_30min_R1 1 TPQASTYSYETSDLCYTAEKK 21 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.007)PQAS(0.066)T(0.066)Y(0.361)S(0.444)Y(0.055)ETSDLCYTAEKK 97.271 0.00018661 8248700.0 840.96 856.64 976.2 787.67 958.6 576.68 883.6 1013.7 517.61 904.59 True False 860.5527317766918 756.3441905588686 843.6374018827676 650.1182208971143 871.8947992545758 570.8791227835459 816.9493406095584 986.8133830383422 878.3463652613576 1020.7029379527648 0.8430981236349843 0.741003246327356 0.8265258877130895 0.6369318601169734 0.8542101397330597 0.5592999702034408 0.8003791409164773 0.9667978276006579 0.8605308484984541 1.0 9.995347334716067 -7.632445157088621 5.006076895232887 0.9334692335059678 0.7424314606346584 0.47801613233587403 0.09258115542175556 0.18125121222874846 7.207638249057474 0.043237353224947525 0.02420910190217954 2.331067464992479e-08 7.632445157088621 -0.1910377728713094 TPQASTYS(ph)YETSDLCYTAEKK ddPTM_A459_Selumetinib_30min_R2 1 TPQASTYSYETSDLCYTAEKK 21 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.059)PQAS(0.059)T(0.062)Y(0.269)S(0.313)Y(0.226)ET(0.004)S(0.005)DLCY(0.002)T(0.002)AEKK 62.002 0.0092241 5735400.0 16224.0 15254.0 16246.0 20883.0 22748.0 16558.0 18563.0 18116.0 13158.0 19733.0 True False 15322.335029817836 16423.93275065936 15200.750047307378 18038.69937481566 19890.19287029975 18838.714201441413 19426.216281886693 18168.71456073475 15789.967665237747 19163.257017508724 0.799568414482904 0.8570533044384602 0.7932237214905088 0.9413169879386578 1.0379338362015837 0.9830643185669957 1.0137220548749992 0.9481015958891904 0.8239709800276157 1.0 14.22605516419716 -5.8471697686010256 5.221261241379248 0.9697731151836476 0.8210255129199177 0.5879489800488367 0.056718607858184555 0.14809868593683911 6.7390956784861995 0.01673807208837851 0.025486541432802164 1.421772897998932e-06 5.8471697686010256 -0.14874760226372996 TPQASTYSY(ph)ETSDLCYTAEKK ddPTM_A459_Selumetinib_30min_R2 1 TPQASTYSYETSDLCYTAEKK 21 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.014)PQAS(0.051)T(0.051)Y(0.169)S(0.205)Y(0.475)ET(0.026)S(0.01)DLCYTAEKK 63.639 0.020569 3689400.0 15803.0 17730.0 17994.0 20399.0 20646.0 14697.0 14340.0 13883.0 12788.0 19645.0 True False 14924.732524421295 19089.83398906454 16836.285630385875 17620.621009762228 18052.26490241818 16721.378343917422 15006.838414170938 13923.397231545625 15345.95732657398 19077.79780616016 0.7823089790584816 1.0006309000140725 0.8825067652698096 0.9236192347144273 0.9462446916482762 0.8764836756220439 0.7866127194893153 0.7298220356989947 0.8043882990320202 1.0 14.219607026915181 -7.083449566145765 4.416419200002192 0.8085570568526175 0.9119350538635459 0.13580299926268724 0.08384277288698008 0.3175701113199905 11.113827246797849 0.03102856567583396 0.024106895397186377 8.25183307000806e-08 7.083449566145765 0.10337799701092842 TPQASTYSYET(ph)SDLCYTAEKKSPSEAR ddPTM_A459_Selumetinib_30min_R2 1 TPQASTYSYETSDLCYTAEKKSPSEAR 27 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TPQASTYSY(0.001)ET(0.272)S(0.272)DLCY(0.23)T(0.093)AEKKS(0.093)PS(0.038)EAR 68.916 0.001072 113450000.0 91602.0 149100.0 100270.0 128120.0 85993.0 44992.0 33187.0 30398.0 14404.0 117250.0 True False 86511.1275518597 160535.49056793688 93818.73736572132 110669.83498067247 75189.79055282593 51189.239603288566 34730.26125879293 30486.453147340195 17285.20248138657 113864.68784791442 0.7597713495461381 1.4098795122712602 0.8239493660320057 0.9719416710516151 0.6603433599471561 0.44956202463454226 0.3050134498693843 0.26774282460651905 0.15180476764204442 1.0 16.796960876746596 -6.441013692202618 1.5460809260217396 0.36667155907050936 1.0414052488157413 0.481863397009886 0.26841437450946914 0.2881025536357473 1.3905904157535214 0.09938329672372816 0.11698273491932397 3.6223157799449184e-07 6.441013692202618 0.6747336897452318 TPQASTYSYETS(ph)DLCYTAEKKSPSEAR ddPTM_A459_Selumetinib_30min_R1 1 TPQASTYSYETSDLCYTAEKKSPSEAR 27 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TPQASTYSY(0.017)ET(0.228)S(0.687)DLCY(0.035)T(0.014)AEKKS(0.014)PS(0.005)EAR 75.17699999999998 5.7069e-05 144220000.0 2916.7 2862.4 6206.0 6721.4 3920.5 4132.7 3153.2 2681.4 2167.0 1900.4 True False 2984.6534350897514 2527.2688773063433 5363.25928711786 5547.633666304248 3565.891467220494 4091.128790191372 2915.3515853441145 2610.2805615852894 3677.2407285820655 2144.334851463574 1.3918784340293842 1.1785793975140613 2.50112956167143 2.5871116456078767 1.6629359284939402 1.9078777679703576 1.3595598576193908 1.2172914877560719 1.7148631082837815 1.0 11.06631449401435 -7.268804757384635 7.990953460374378 1.3400962634734115 1.8920494208998968 0.27059347910089326 0.44018014662014066 0.21980842705719478 126.31228320068013 0.19502915498704826 0.1382514630004963 5.385118229543415e-08 7.268804757384635 0.5519531574264853 TPQASTYSYETSDLCYTAEKKS(ph)PSEAR ddPTM_A459_Selumetinib_30min_R1 2 TPQASTYSYETSDLCYTAEKKSPSEAR 27 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TPQASTYSYET(0.001)S(0.002)DLCY(0.094)T(0.038)AEKKS(0.685)PS(0.181)EAR;TPQASTYSYETSDLCY(0.012)T(0.006)AEKKS(0.821)PS(0.161)EAR 86.955 5.8561e-05 63528000.0 1400.1 1415.9 2824.0 3016.3999999999996 1893.6999999999998 1976.7 1326.98 1294.8400000000001 955.8499999999999 1070.97 True False 1432.7196058796444 1250.1257697659487 2440.5163111216307 2489.6423648406776 1722.4151693598901 1956.816192699999 1226.8848302422732 1260.4966369669203 1622.007637478157 1208.4394316312066 1.185594882439159 1.034496009517392 2.01956030831211 2.0602127832588555 1.425321885628058 1.6192919077943355 1.015263817224309 1.0430780426168687 1.342233292808641 1.0 10.23892945004933 -7.258374687513287 24.708264295829984 1.1037336135523728 1.5715011192233876 0.33816939770473964 0.3130008581555569 298.5621199845001 2407092.8910017605 0.13587063537966235 0.10062773443610379 5.516013399416735e-08 7.258374687513287 0.4677675056710149 TPQEAIMDGTEIAVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 TPQEAIMDGTEIAVSPR 17 0 Q06587 Q06587 RING1 E3 ubiquitin-protein ligase RING1 1 TPQEAIMDGTEIAVS(1)PR;TPQEAIMDGTEIAVS(1)PR 181.6 7.2906e-08 25324000.0 2040.83 2247.0699999999997 2365.9 2481.9700000000003 2120.83 1665.44 2316.8 1829.63 1357.49 1855.42 True False 2088.3773682360948 1983.981999765499 2044.6237749584498 2048.540531847109 1929.0013009629486 1648.6871856985308 2142.04191073362 1781.1022689241804 2303.5613828531914 2093.581230321273 0.9975143729749719 0.9476498790835285 0.976615449807357 0.9784862904663832 0.9213883239997005 0.7874961629482748 1.0231472654179798 0.8507442859768376 1.1002971126655046 1.0 11.03175717995939 -8.27257109323263 24.929610027139855 1.050148555816925 0.9361303141469377 0.298420904436389 0.07038160547344598 978.6720338241253 2191723.2488690177 0.06400273090919913 0.017127139894150857 5.338618741835259e-09 8.27257109323263 -0.11401824166998731 TPQEAIMDGTEIAVS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TPQEAIMDGTEIAVSPR 17 0 Q06587 Q06587 RING1 E3 ubiquitin-protein ligase RING1 1 TPQEAIMDGTEIAVS(1)PR;TPQEAIMDGT(0.002)EIAVS(0.998)PR 212.34 2.2408000000000004e-09 6401500.0 17903.6 16382.0 18303.4 18081.6 20195.7 8851.8 13721.3 15632.900000000001 12454.4 18006.5 True False 16908.589585789352 17638.446723567686 17125.779171235125 15618.854887500203 17658.53561415124 10071.05510136002 14359.367638240145 15678.38915083408 14945.628005011173 17486.605558494433 0.9669452158241026 1.0086832841608584 0.9793655557648219 0.8931896379347942 1.0098321000654862 0.5759296775850145 0.8211638096488557 0.8965942016812989 0.8546900629179609 1.0 14.093962644840774 TPQEAITDGLEIVVS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TPQEAITDGLEIVVSPR 17 0 X6RFN3;Q99496-2;Q99496 X6RFN3 RNF2 E3 ubiquitin-protein ligase RING2 1 TPQEAIT(0.002)DGLEIVVS(0.998)PR 103.2 0.0032773000000000004 3758800.0 794.27 1053.2 1434.4 1000.7 1057.3 1013.6 1194.4 749.39 536.16 793.46 True False 812.7749456196173 929.8908543806035 1239.616358595207 825.9465304654778 961.6674016814765 1003.4041042751657 1104.3054463830438 729.5137428382196 909.8243604229631 895.3083199548986 0.9078156960057748 1.0386263968008775 1.384569238290618 0.9225274824957341 1.0741186921282277 1.1207358201761293 1.2334359256693532 0.8148184559202679 1.0162134542308239 1.0 9.806240782845022 -7.764037398915209 24.999995070806026 0.9366369981902153 1.0994640482474332 0.20043951230282986 0.14044653722919034 108.61981346291125 1045173.6430074273 0.07248197721767288 0.03733135468509354 1.721720304061795e-08 7.764037398915209 0.16282705005721787 TPQGPVSATVEVS(ph)SPTGFAQSQVLEDVSQAAR ddPTM_A459_Selumetinib_30min_R1 2 TPQGPVSATVEVSSPTGFAQSQVLEDVSQAAR 32 0 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 TPQGPVSATVEVS(0.651)S(0.349)PTGFAQSQVLEDVSQAAR;TPQGPVSATVEVS(0.632)S(0.332)PT(0.036)GFAQSQVLEDVSQAAR 212.51 2.5093e-55 33373000.0 1467.63 2085.18 1842.25 1989.8400000000001 1830.04 1600.0700000000002 2092.2 1944.49 1046.46 1332.6 True False 1501.8229234891396 1841.0461562261169 1592.0825687548943 1642.3517979228805 1664.5132051198038 1583.9747485473213 1934.3836695601165 1892.9158086063173 1775.766189585597 1503.6521906232153 0.9987834506240985 1.2243829841148721 1.0588103942408567 1.092241815071728 1.1069802016049448 1.0534183093836447 1.2864568559291474 1.2588787622633428 1.1809687111549374 1.0 10.554255180871642 -7.247255146406831 24.98472175175695 1.2031493176292243 1.0948303110190922 0.18567189177412025 0.08999063992044959 1073.806384377794 1891450.748149301 0.032691932418585166 0.025199397688252113 5.659067232438791e-08 7.247255146406831 -0.10831900661013205 TPQGPVSATVEVS(ph)SPTGFAQSQVLEDVSQAAR ddPTM_A459_Selumetinib_30min_R2 3 TPQGPVSATVEVSSPTGFAQSQVLEDVSQAAR 32 0 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 TPQGPVSATVEVS(0.486)S(0.486)PT(0.027)GFAQSQVLEDVSQAAR;TPQGPVSATVEVS(0.589)S(0.376)PT(0.034)GFAQSQVLEDVSQAAR;TPQGPVSATVEVS(0.647)S(0.352)PTGFAQSQVLEDVSQAAR 204.53 3.9129e-49 6768100.0 14619.7 14995.9 18598.8 19331.9 18603.2 13979.0 16515.699999999997 15034.400000000001 20157.800000000003 20845.6 True False 13807.195601296084 16146.03731058166 17402.173456842334 16698.861870612393 16266.09970128189 15904.480361272485 17283.7127752387 15078.147614921092 24189.923255991016 20243.733364626754 0.6820478887270038 0.7975819983281702 0.8596326153579127 0.8248904275627066 0.8035128406554073 0.7856495674391494 0.8537808942613174 0.7448303800161763 1.1949338998042578 1.0 14.305187757029666 -8.256399957025149 24.99880462000232 1.097466960385129 0.7993609343799727 0.7730615208387169 0.06571905135861224 165.19920605254205 819505.7263027504 0.04524009628771621 0.01590913025892516 5.541151738031821e-09 8.256399957025149 -0.29810602600515634 TPQGPVSATVEVSS(ph)PTGFAQSQVLEDVSQAAR ddPTM_A459_Selumetinib_30min_R2 2 TPQGPVSATVEVSSPTGFAQSQVLEDVSQAAR 32 0 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 TPQGPVSATVEVS(0.248)S(0.658)PT(0.094)GFAQSQVLEDVSQAAR;TPQGPVSATVEVS(0.252)S(0.744)PT(0.003)GFAQSQVLEDVSQAAR 131.5 5.945600000000001e-19 4405600.0 7862.0 9228.1 9993.1 9003.2 12183.9 6690.8 10610.7 9879.5 9835.900000000001 13259.3 True False 7425.061514079617 9935.865596981754 9350.154825664611 7776.94862861372 10653.249556552002 7612.396966964866 11104.118574703178 9908.24770936073 11803.354838008216 12876.469557201297 0.5766379892481535 0.7716296421813089 0.7261427353303873 0.6039659080515887 0.8273424255947597 0.5911866550958105 0.8623573818409788 0.7694848083432497 0.9166607963133084 1.0 13.652449472187055 -8.151000910034671 0.7460536605990605 1.002499892060534 0.6861369906796392 0.5980964863067827 0.08617784900389822 0.42427099819869124 0.5043820843483519 0.07694471207548384 0.0319336389097443 7.063160742239176e-09 8.151000910034671 -0.31636290138089473 TPQNVPAS(ph)PGGDR ddPTM_A459_Selumetinib_30min_R1 2 TPQNVPASPGGDR 13 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 TPQNVPAS(1)PGGDR;TPQNVPAS(1)PGGDR 128.74 0.0017957 19941800.0 3386.1 3935.7 3657.5 4534.299999999999 5383.0 3460.6 4543.2 3913.8 1484.02 2915.7 True False 3464.9895417963476 3474.9064143427095 3160.831589209405 3742.469624352566 4896.108600445839 3425.7895059733996 4200.502766248698 3809.9933101859137 2518.2735514676306 3289.958496323062 1.0532015968192014 1.0562158818192844 0.9607512048380027 1.13754311142078 1.4881976796722056 1.0412865420041455 1.2767646676829763 1.1580672870019655 0.7654423465469594 1.0 11.683853668766501 -8.245791159319456 23.971779292283216 0.8827211920682587 1.1492281215794846 0.3319453101426929 0.14964510411129278 482.9326045629054 739817.3626126655 0.10568042553334507 0.03959103762489647 5.678175881638903e-09 8.245791159319456 0.2665069295112259 TPQNVPAS(ph)PGGDR ddPTM_A459_Selumetinib_30min_R2 4 TPQNVPASPGGDR 13 0 H0YLX2;A0A669KBM4;Q2KHR2-2;Q2KHR2 H0YLX2 RFX7 DNA-binding protein RFX7 1 TPQNVPAS(1)PGGDR;TPQNVPAS(1)PGGDR;TPQNVPAS(1)PGGDR;TPQNVPAS(1)PGGDR 130.4 0.001629 41240800.0 90179.0 107568.0 117499.0 127359.0 127560.0 91252.6 83653.0 92154.0 104062.0 106235.0 True False 85167.21219513942 115818.11971436488 109939.24226323827 110012.48449347063 111534.77239913117 103821.8173413729 87543.03025527477 92422.15288308413 124877.30773521563 103167.7195183214 0.8255219034866298 1.1226197521386223 1.0656360611297055 1.0663459947269036 1.0811014619677026 1.006340140366632 0.8485505995868032 0.8958437126902956 1.2104300484517236 1.0 16.65463210628389 -6.999422330770705 24.488056787260447 0.972514830737617 1.0412859569109996 0.020337725149188746 0.1160087051935464 45.98783783715817 1949366.2330949006 0.0409140017726901 0.035747935352928854 1.0013310175747181e-07 6.999422330770705 0.06877112617338255 TPQS(ph)PTLPPAK ddPTM_A459_Selumetinib_30min_R2 1 TPQSPTLPPAK 11 0 P78310-7;P78310-2;P78310-6;P78310 P78310-7 CXADR Coxsackievirus and adenovirus receptor 1 T(0.438)PQS(0.457)PT(0.105)LPPAK 79.089 0.046346 11134000.0 166680.0 71550.0 105800.0 104660.0 68016.0 59043.0 155240.0 107390.0 67436.0 75482.0 True False 157416.59287290636 77037.65493048886 98992.94318633014 90405.12745142984 59471.22200924506 67175.63731101007 162458.96760222426 107702.48712062853 80925.08431927122 73302.63853421125 2.147488767398708 1.0509533690869044 1.3504690303900713 1.2333134148948357 0.8113107958793203 0.9164149975264311 2.216277215265623 1.4692852709573674 1.1039859674560348 1.0 16.161577508764083 -4.752860397764402 24.929557782699955 1.2641593995959473 2.1474904912427513 0.3410580558066729 0.37734554460858394 408.8221140418615 1187898.1742428953 0.09938007745494525 1.132445242451305 1.76660559777647e-05 4.752860397764402 0.883331091646804 TPQSPT(ph)LPPAK ddPTM_A459_Selumetinib_30min_R2 1 TPQSPTLPPAK 11 0 P78310-7;P78310-2;P78310-6;P78310 P78310-7 CXADR Coxsackievirus and adenovirus receptor 1 T(0.313)PQS(0.045)PT(0.642)LPPAK 108.32 0.015908000000000002 0.0 29917.0 11347.0 16062.0 20009.0 15786.0 8450.6 28186.0 17384.0 13283.0 12789.0 True False 28254.33290723987 12217.27841364441 15028.588406983332 17283.739682549753 13802.821551369436 9614.593443091004 29496.70484949943 17434.58456192387 15939.971158029563 12419.748340187447 2.274952127316087 0.9836977432233557 1.210055791416826 1.391633647408422 1.1113608080694102 0.7741375412560005 2.374984101252268 1.403779213908028 1.2834375320191864 1.0 13.600348320254225 TPS(ph)DDEEDNLFAPPK ddPTM_A459_Selumetinib_30min_R2 4 TPSDDEEDNLFAPPK 15 0 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;F8W7U3;Q641Q2-2;Q641Q2;E7ESD2 A0A0A0MR88;F8W7U3 FAM21C;FAM21A WASH complex subunit FAM21C;WASH complex subunit FAM21A 1 T(0.023)PS(0.977)DDEEDNLFAPPK;T(0.05)PS(0.95)DDEEDNLFAPPK;T(0.38)PS(0.62)DDEEDNLFAPPK;T(0.001)PS(0.999)DDEEDNLFAPPK 166.3 8.05e-05 10781500.0 185670.0 153195.0 173484.0 181478.0 172009.0 139653.0 167126.0 171254.0 121173.6 170211.0 True False 175351.2046958997 164944.56390043674 162322.22831509757 156760.38333298868 150399.6916400293 158888.93310628703 174897.69015388645 171752.32078737396 145411.70587326738 165296.56616871117 1.0608278729573015 0.9978704804556244 0.9820060517737688 0.9483583777111863 0.9098778947804804 0.9612355343432595 1.0580842313165526 1.0390555881969967 0.8797019154339348 1.0 17.334697229176975 -4.737389556270925 2.0239166524926344 0.9732767572915061 1.0926728513363337 0.21794524380594704 0.05082778925859258 1.4563031629204564 5.983332735278525 0.014406721454996685 0.33855774837799113 1.830671598045382e-05 4.737389556270925 0.11939609404482765 TPS(ph)EIQFHQVK ddPTM_A459_Selumetinib_30min_R2 1 TPSEIQFHQVK 11 0 C9JCU6;Q12851-2;Q12851 C9JCU6 MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 1 T(0.011)PS(0.989)EIQFHQVK 83.869 0.024654 5639200.0 40319.0 39143.0 43326.0 43353.0 39516.0 37192.0 36776.0 40903.0 32529.0 34609.0 True False 38078.231389745124 42145.142235417545 40538.45232978204 37448.2466119036 34551.64680247779 42314.860404638806 38486.15687026153 41022.02095814384 39035.70893619994 33609.748245018964 1.132951996907278 1.2539559037507384 1.2061516210788614 1.114207888107389 1.0280245644981414 1.2590055746969173 1.1450891149107392 1.2205393702769967 1.1614400873111304 1.0 15.036592115678763 -8.584245820069539 20.088258142022895 0.999999999419617 1.170881001108527 0.3688761569695117 0.06640857186883876 6164.922129150597 2018060.1982012596 0.06570848253710299 0.016965857243068795 2.604678828126155e-09 8.584245820069539 0.17088100168891007 TPS(ph)FELPDASERPPTYCELVPR ddPTM_A459_Selumetinib_30min_R2 1 TPSFELPDASERPPTYCELVPR 22 1 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 T(0.177)PS(0.8)FELPDAS(0.016)ERPPT(0.003)Y(0.003)CELVPR 56.131 0.0132 8841800.0 4683.6 3626.3 4807.7 4020.2 4264.4 2520.7 5208.7 4249.5 4280.7 3732.4 True False 4423.304261936318 3904.425549607714 4498.377816227971 3472.641824768182 3728.667947780299 2867.903544363654 5450.914870843248 4261.865341457402 5136.959612751427 3624.6359140601794 1.2203444337065845 1.0771911006184687 1.2410564599822274 0.9580663843498313 1.028701374755068 0.7912252740306646 1.5038516971315168 1.1758050856709144 1.417234650472025 1.0 11.823620371828348 -7.269182717532833 24.99981387054621 1.2888732611672988 1.0570350163068596 0.27937335063130087 0.1735272732270325 772.8836610851054 2495288.487900002 0.06980947078122744 0.048044717513089516 5.3804336784987596e-08 7.269182717532833 -0.23183824486043925 TPS(ph)GEFLER ddPTM_A459_Selumetinib_30min_R1 2 TPSGEFLER 9 0 B3KT28;B1ANM7;Q9UNN5-2;Q9UNN5 B3KT28 FAF1 FAS-associated factor 1 1 T(0.055)PS(0.945)GEFLER;T(0.327)PS(0.673)GEFLER 106.4 0.01319 6505300.0 2295.0 3316.7 2369.7 3054.5 2909.8999999999996 2339.6000000000004 2551.9 2451.8 1352.67 1874.67 True False 2348.469034707369 2928.3792221080034 2047.907755830356 2521.0889150662556 2646.7000587845714 2316.065748186835 2359.4081284535223 2386.7702994311994 2295.3821948920645 2115.3021553321514 1.1102286398127386 1.384378687804145 0.9681395873719928 1.1918339461391918 1.2512160743149143 1.094910125415704 1.1154000493527794 1.1283353980492783 1.0851320645166347 1.0 11.046648041087195 -10.342989274755748 0.11660302013868301 0.7939138222973203 1.281488552624313 0.21130867703240364 0.10129125637202563 59.304426967901584 1.5054441904007432 5.218377908211104 1.5329712441474312 4.539528272343469e-11 10.342989274755748 0.4875747303269926 TPS(ph)IQPSLLPHAAPFAK ddPTM_A459_Selumetinib_30min_R1 2 TPSIQPSLLPHAAPFAK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;H0YF36 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 T(0.038)PS(0.962)IQPSLLPHAAPFAK;T(0.466)PS(0.531)IQPS(0.003)LLPHAAPFAK 145.19 0.00032073 51890000.0 7388.9 5173.3 7196.8 7124.700000000001 10356.5 5237.4 7315.4 7742.7 2037.94 4495.0 True False 7561.046993703382 4567.607630998078 6219.514089192688 5880.504892182862 9419.75640358858 5184.716511178723 6763.593488337668 7537.338444165895 3458.2353347515145 5071.977035007771 1.4907494536184938 0.9005576325506923 1.2262504436168369 1.1594107882576115 1.8572159019198218 1.0222279153459888 1.3335221042315515 1.4860750338855482 0.68183182038919 1.0 12.308332497892678 -8.263680838929567 24.99728148443508 0.8409158899119039 1.2975737550792534 0.3348583998373442 0.2637365995994984 237.4650580926351 2648172.086244298 0.2132499014040817 0.06530812988369353 5.4490295247546884e-09 8.263680838929567 0.4566578651673495 TPS(ph)IQPSLLPHAAPFAK ddPTM_A459_Selumetinib_30min_R2 1 TPSIQPSLLPHAAPFAK 17 0 P35658-4;P35658-3;A0A494C1F2;P35658-2;P35658;P35658-5;A0A0A0MSW3;H0YF36 P35658-4 NUP214 Nuclear pore complex protein Nup214 1 T(0.153)PS(0.847)IQPSLLPHAAPFAK 114.53 0.0011269 17602000.0 66290.0 34675.0 77782.0 101450.0 114290.0 50357.0 43743.0 75975.0 44954.0 89723.0 True False 62605.867179895395 37334.46100230193 72777.59080263818 87632.33498898841 99931.86843443624 57293.219654667606 45777.1361751101 76196.07467166164 53946.056119706496 87132.46386164986 0.7185136791185185 0.42847934452516007 0.8352522995125612 1.00573691027643 1.146895932991284 0.6575415994851079 0.5253740586034119 0.8744854821579111 0.6191269445262423 1.0 16.41092271865071 -5.283591407804862 23.828803112945856 0.8286883793968491 0.573496531944373 0.22471606099062547 0.19270628690825742 611.309193021178 657581.1593062838 0.053752923267087686 0.11207183109778278 5.204854484883279e-06 5.283591407804862 -0.25519184745247614 TPS(ph)PAAEDAREPEAK ddPTM_A459_Selumetinib_30min_R2 2 TPSPAAEDAREPEAK 15 1 Q92797 Q92797 SYMPK Symplekin 1 T(0.4)PS(0.6)PAAEDAREPEAK;T(0.436)PS(0.564)PAAEDAREPEAK 85.163 0.01155 244914000.0 304177.0 211453.0 296212.0 313074.0 309743.0 238542.0 250607.0 279957.0 195730.0 253813.0 True False 287272.06005700777 227670.76517144236 277154.04241124104 270432.781117226 270830.3152024469 271398.9952313227 262260.7220683497 280771.6285206239 234881.4691531381 246484.7592046282 1.1654759547162041 0.9236707612515436 1.1244266919609078 1.0971582258873722 1.098771039947372 1.101078200969055 1.064003806623291 1.13910340512182 0.952924918810671 1.0 17.91113891820158 -8.27151234276948 24.951556173829008 0.9764624440018128 1.0850057665823543 0.34044970560229215 0.06255366160588424 856.5458556156609 2121710.0485072564 0.05497116480253093 0.014851155307764983 5.351649440191996e-09 8.27151234276948 0.10854332258054145 TPS(ph)PARPALR ddPTM_A459_Selumetinib_30min_R2 2 TPSPARPALR 10 1 Q9H211 Q9H211 CDT1 DNA replication factor Cdt1 1 T(0.004)PS(0.996)PARPALR;TPS(1)PARPALR 82.505 0.023349 23881100.0 63720.0 60763.0 65989.0 69087.0 72840.0 56430.0 56017.0 63139.0 57235.0 68597.0 True False 60178.697491370316 65423.326716160656 61743.33958339073 59677.23141827758 63689.18800213786 64202.72027946246 58621.9014955797 63322.724036775864 68683.59927951681 66616.42637358961 0.9033612393718622 0.9820900080899272 0.9268485709084683 0.8958335753948052 0.9560583097772974 0.9637671033178676 0.8799916880383819 0.9505572046398522 1.0310309786708514 1.0 16.02359034251721 -8.153551220524296 4.855083715007883 1.0145786432345711 0.9316557185163253 0.5435140288115858 0.03085653254712167 0.16587378213394122 5.871612469364381 0.02215241114462932 0.0078647738044596 7.02180523950847e-09 8.153551220524296 -0.0829229247182458 TPS(ph)PESHR ddPTM_A459_Selumetinib_30min_R2 1 TPSPESHR 8 0 Q66K74-2;Q66K74 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 T(0.411)PS(0.589)PESHR 70.41199999999998 0.045082 0.0 5781.7 4711.3 5072.4 5417.4 5107.3 3942.7 7313.6 11940.0 5247.5 7784.0 True False 5460.376259978903 5072.6415607828385 4746.047306411542 4679.540774463742 4465.675314158688 4485.771136732883 7653.696891623465 11974.743423226593 6297.146627400447 7559.255694739162 0.722343108962306 0.6710504004135124 0.6278458485951913 0.6190478220918565 0.5907559546195215 0.5934143939402314 1.0124934518288657 1.584116731434336 0.8330379182414644 1.0 12.884028474350245 -7.38037765515796 4.301684328419631 1.1786563515790052 0.6364255920773032 0.6139078767846395 0.1828673944224731 0.13615305637934202 4.151669517735164 0.0756639509156863 0.04945872001581525 4.165070384515254e-08 7.38037765515796 -0.542230759501702 TPS(ph)PPPPIPEDIALGK ddPTM_A459_Selumetinib_30min_R1 1 TPSPPPPIPEDIALGK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 T(0.101)PS(0.899)PPPPIPEDIALGK 116.58 0.0019093 7163100.0 1115.8 1827.6 1483.0 1518.7 1305.8 1255.1 1450.6 1437.4 647.03 1217.1 True False 1141.7959690311468 1613.6237423718112 1281.6167455358984 1253.4875545297502 1187.690620557714 1242.4748335396202 1341.1800741152401 1399.2754826667779 1097.962652798548 1373.3266405579436 0.8314088835903362 1.1749744705427412 0.9332206247853853 0.9127381043307321 0.8648274820294676 0.90471909365629 0.9765921919131757 1.0188948800252589 0.7994912647674824 1.0 10.423459090530935 -5.48335412780662 24.999230644240242 0.9247222801862934 1.0159181518912774 0.0870085289328758 0.09817444983717212 1025.8891088816395 648870.6496567874 0.024216743017449367 0.05039759025570392 3.28583591457937e-06 5.48335412780662 0.091195871704984 TPS(ph)PPPPIPEDIALGK ddPTM_A459_Selumetinib_30min_R2 1 TPSPPPPIPEDIALGK 16 0 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 T(0.026)PS(0.974)PPPPIPEDIALGK 101.04 0.005691300000000001 4309000.0 6223.1 5343.9 6396.7 6172.2 4780.6 4743.7 3093.5 4232.8 3650.7 5092.5 True False 5877.245015043102 5753.75994665324 5985.143286200363 5331.535712361115 4180.018288893745 5397.101615978844 3237.35387965396 4245.116747222237 4380.9420090806725 4945.466293095988 1.188410691070305 1.1634413431723625 1.2102283043675364 1.0780653221323317 0.8452222785805193 1.0913231020325327 0.6546104427348739 0.858385538518085 0.8858501401974154 1.0 12.271890839422383 -6.093969561028334 2.7856622402975644 0.8786854185092265 1.185291465332192 0.6147599914334237 0.10698657737783927 0.17977606565212897 2.7163205473452092 0.033228812633628965 0.046541745182791486 8.054348908011158e-07 6.093969561028334 0.30660604682296544 TPS(ph)PSPPCSSSPSPSGR ddPTM_A459_Selumetinib_30min_R1 2 TPSPSPPCSSSPSPSGR 17 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.002)PS(0.995)PS(0.002)PPCSSSPSPSGR;T(0.125)PS(0.871)PS(0.005)PPCSSSPSPSGR 193.31 8.579700000000001e-08 10628900.0 675.56 854.58 746.26 734.49 722.0 657.54 630.66 859.602 520.17 625.033 True False 691.2992335890668 754.5253763165366 644.9219909127575 606.2251095848795 656.6952274794529 650.925744598552 583.0888084527207 836.80256257919 882.6904982863554 705.2620738869888 0.9802019124309819 1.0698510585689622 0.914443034428787 0.8595742377634517 0.931136455218889 0.9229558325900513 0.8267689842430899 1.186512919895476 1.251578003367579 1.0 9.462015649327547 -7.7742657986484724 24.980664801424062 1.1642842045984412 0.9312598138113218 0.5718017072678732 0.08550758161237618 161.20971975698518 313966.4098779502 0.047214481215373694 0.02291132534230683 1.6816445392294822e-08 7.7742657986484724 -0.23302439078711934 TPS(ph)PSPPCSSSPSPSGR ddPTM_A459_Selumetinib_30min_R2 2 TPSPSPPCSSSPSPSGR 17 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.025)PS(0.973)PS(0.001)PPCSSSPSPSGR;T(0.091)PS(0.875)PS(0.032)PPCS(0.001)SSPSPSGR 183.75 6.4252e-08 15576000.0 7470.0 5850.0 7332.7 8826.2 10336.3 8507.3 12749.2 24816.0 13145.6 16463.0 True False 7054.847304779287 6298.676189285256 6860.922065240105 7624.056333955755 9037.761586305573 9679.103353419658 13342.063062060528 24888.21045149003 15775.087318752809 15987.670413989055 0.441267997281603 0.3939708554270656 0.42913832269377195 0.47687099724577636 0.5652957155282373 0.6054104883817555 0.8345220233203177 1.5567127547058444 0.9867033101301463 1.0 13.964672116552006 -7.397373439476557 2.5726626942858313 1.2038874584020602 0.47235146262595135 0.7823781624777189 0.16338736943785293 0.11870331596454842 1.5280331705132804 0.07813029139222394 0.04710144693724786 4.005221700440828e-08 7.397373439476557 -0.731535995776109 down TPS(ph)PSQPK ddPTM_A459_Selumetinib_30min_R1 1 TPSPSQPK 8 0 Q9NTI5-2;Q9NTI5 Q9NTI5-2 PDS5B Sister chromatid cohesion protein PDS5 homolog B 1 T(0.453)PS(0.498)PS(0.05)QPK 104.42 0.014616999999999996 66976000.0 5962.8 9014.5 8068.7 8887.6 7060.1 7698.2 7578.3 6603.1 3561.8 5401.1 True False 6101.721638410936 7959.078149272649 6973.014858196566 7335.5475009143365 6421.515201561893 7620.7630974063495 7006.66272967567 6427.964338108386 6044.114456420676 6094.383796169184 1.0012040334982455 1.3059693014863254 1.1441706153425508 1.2036569645524007 1.0536775195546986 1.2504567077309143 1.1496917430897489 1.0547357293363908 0.9917515303548643 1.0 12.573264641823812 -7.875079881411841 2.8567316859509377 1.0000770647090913 1.1657492911718437 0.3956147348752801 0.08281878472226667 0.25654865786083564 4.103544836217541 0.05239691694902227 0.021505608932678548 1.3332761751243334e-08 7.875079881411841 0.16567222646275237 TPS(ph)SEEISPTK ddPTM_A459_Selumetinib_30min_R1 3 TPSSEEISPTK 11 0 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.343)PS(0.611)S(0.046)EEISPTK;T(0.151)PS(0.807)S(0.042)EEISPTK;T(0.116)PS(0.871)S(0.014)EEISPTK 156.0 0.00054161 60182000.0 8989.2 13116.499999999998 6908.0 8968.199999999999 8587.300000000001 7901.099999999999 10328.1 9248.1 4620.7 8434.7 True False 9198.630870061646 11580.81408230458 5969.93154292784 7402.072223963716 7810.580231210959 7821.622107624808 9549.043101798989 9002.810345937543 7840.990417424614 9517.375905935494 0.966509147161555 1.2168074684411936 0.6272665493021772 0.7777429721303145 0.8206653082116789 0.8218254889718991 1.0033273032584271 0.9459340930647656 0.8238605362361062 1.0 13.216348138726365 -10.04482791375227 24.84253939243859 0.9999999999999948 0.8889819348151389 0.04688346513231034 0.14969484187512655 0.0 0.0 0.15156020197721723 0.03675874831717726 9.019284498510574e-11 10.04482791375227 -0.11101806518485591 TPS(ph)SEEISPTK ddPTM_A459_Selumetinib_30min_R2 1 TPSSEEISPTK 11 0 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.016)PS(0.648)S(0.336)EEISPTK 158.86 0.00057871 43059000.0 61731.0 41098.0 53394.0 59638.0 56009.0 36902.0 51909.0 57251.0 45564.0 43479.0 True False 58300.23814877248 44250.08444910177 49958.68817099165 51515.20151871169 48972.64869318705 41984.915536996734 54322.87135573213 57417.59093158672 54678.07316453054 42223.64829799123 1.3807484786089903 1.0479929194372088 1.1831921253798527 1.2200556701104035 1.1598393475515212 0.9943459939958372 1.2865508677116495 1.3598443821425619 1.29496325799805 1.0 15.365763618443522 TPS(ph)SEEISPTKFPGLYR ddPTM_A459_Selumetinib_30min_R2 1 TPSSEEISPTKFPGLYR 17 1 J3QLT3;E7ENF8;A0A1W2PRI7;Q15311 J3QLT3 RALBP1 RalA-binding protein 1 1 T(0.253)PS(0.64)S(0.108)EEISPTKFPGLYR 68.283 0.020306 13100000.0 24928.0 22008.0 26973.0 24406.0 27633.0 15879.0 20636.0 20175.0 16974.0 21817.0 True False 23542.601554690504 23695.94283312646 25237.586545981903 21081.86069730168 24161.495497845648 18066.18811478974 21595.61488945826 20233.705909848948 20369.27429318631 21187.08652262645 1.1111769204108604 1.1184144081264176 1.1911777732643787 0.9950334924430314 1.140387824066453 0.8526980854822209 1.019281951126009 0.9550018067958823 0.9614004394343333 1.0 14.37089759310453 -6.7424170682616875 24.999999849398 0.9587143926752222 1.1096220815686526 0.6115054040245231 0.06118950634842844 164.74056787852177 216509.1938698903 0.019579832837404797 0.019549712027896893 1.809601434019214e-07 6.7424170682616875 0.15090768889343043 TPS(ph)SPCPASK ddPTM_A459_Selumetinib_30min_R1 1 TPSSPCPASK 10 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.012)PS(0.694)S(0.292)PCPAS(0.002)K 100.09 0.017800999999999997 63878000.0 9566.3 10766.0 9743.9 10096.0 9476.1 8975.8 9419.5 9015.2 4887.8 7885.9 True False 9789.176177220521 9505.511715022385 8420.731899411492 8332.92312539169 8618.988428141336 8885.511601374335 8708.979531317043 8776.087610503368 8294.239609212473 8898.132080170813 1.1001383311712545 1.0682592289459376 0.9463482699000174 0.9364800443860939 0.968628960604941 0.9985816709976015 0.978742443116203 0.9862842595987737 0.9321326694729454 1.0 13.119286798099724 -5.161060269558234 4.475068037379856 0.9683348654204472 1.0921091979762367 0.8016866164158698 0.02319108569524795 0.09325812789685524 3.0898357794758087 0.00623404412396189 0.018186090433987657 6.901440219149524e-06 5.161060269558234 0.12377433255578951 TPS(ph)SPCPASK ddPTM_A459_Selumetinib_30min_R2 2 TPSSPCPASK 10 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.244)PS(0.55)S(0.205)PCPAS(0.001)K;T(0.003)PS(0.596)S(0.401)PCPASK 115.33 0.0066818 44899000.0 102136.0 86149.0 94437.0 103325.0 96443.0 80692.0 90605.0 91560.0 82041.0 88600.0 True False 96459.69000280285 92756.35128730521 88361.0262352313 89251.95675443299 84326.96812864058 91806.59055095492 94818.31203040153 91826.4244414261 98451.49241706733 86041.88778955415 1.1210782617732553 1.0780371476062176 1.0269535978958229 1.0373082117018422 0.9800687815554674 1.0669987945348245 1.102001762935667 1.0672293088922 1.1442274797348153 1.0 16.392751557898876 -6.9963635285203445 24.99971810044107 1.0840432580565558 1.0459852301175279 0.07391801976881085 0.04768583356762109 243.03742160747578 1670798.1002873732 0.017013145786698106 0.014937941632500644 1.0084084390208204e-07 6.9963635285203445 -0.038058027939027905 TPS(ph)SPLQSCTPSLSPR ddPTM_A459_Selumetinib_30min_R1 2 TPSSPLQSCTPSLSPR 16 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 T(0.012)PS(0.669)S(0.319)PLQSCTPSLSPR;T(0.123)PS(0.531)S(0.346)PLQSCTPSLSPR 164.63 2.3185e-05 12163700.0 1866.79 2187.37 2487.7 2385.7 2033.6599999999999 2021.6799999999998 2176.24 2033.21 1029.02 1622.5700000000002 True False 1910.2825748589828 1931.271703519276 2149.8840039579604 1969.0822801353954 1849.715812071835 2001.3437347385718 2012.084464699124 1979.2826660031428 1746.1717833527991 1830.842664670203 1.0433898071755334 1.0548539974444846 1.1742592880558786 1.0755060050395395 1.010308448544393 1.0931271011750656 1.0989936511347187 1.0810774209042582 0.9537530542895362 1.0 10.838292101655911 -8.253669628996468 24.32069149609731 0.9768765243727117 1.080053193154592 0.4899682406774578 0.04164025279071563 314.0953287543464 983184.7335706619 0.030542139143087534 0.011041585884700843 5.5760976548108745e-09 8.253669628996468 0.10317666878188037 TPS(ph)SPSKSPASFEIPASAMEANGVDGDGLNKPAK ddPTM_A459_Selumetinib_30min_R1 1 TPSSPSKSPASFEIPASAMEANGVDGDGLNKPAK 34 2 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0YA73 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 T(0.22)PS(0.248)S(0.248)PS(0.248)KS(0.03)PAS(0.004)FEIPASAMEANGVDGDGLNKPAK 93.667 6.639500000000001e-10 84533000.0 6734.2 7700.6 10045.0 9979.2 7778.8 7603.9 7698.6 7426.9 4512.1 6986.2 True False 6891.093757527825 6799.010172088186 8680.944173235404 8236.520052784148 7075.208913458681 7527.411669788802 7117.888403821585 7229.91448602886 7656.704149254792 7882.946821350682 0.8741773747431026 0.8624960089383462 1.1012308429790971 1.0448529261260302 0.8975335079383929 0.9548981923106565 0.9029476622299464 0.917158855676521 0.9712997338148827 1.0 12.944519326757765 -6.321866439375835 24.999955058745254 0.9353259660495097 0.9722872441458081 0.03665216456404652 0.07227620708872796 882.6604062477224 365172.7023231981 0.024255482332580357 0.027503139472109677 4.7657752839922556e-07 6.321866439375835 0.036961278096298456 TPS(ph)SQNLLALLAR ddPTM_A459_Selumetinib_30min_R1 1 TPSSQNLLALLAR 13 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.24)PS(0.716)S(0.043)QNLLALLAR 144.4 0.00067113 64833000.0 460.78 342.82 384.54 465.43 518.22 259.98 299.26 343.08 274.79 363.05 True False 471.5152774781963 302.6824750273059 332.32158012702257 384.15138770315497 471.34709249917205 257.3648372429533 276.6865772643917 333.9804039191026 466.29856013247144 409.65100390646774 1.151017019320801 0.7388788801709245 0.8112309672330227 0.9377528287245821 1.1506064625848955 0.6282538912115428 0.675420234848406 0.8152803257754438 1.1382824787094568 1.0 8.678251540127233 -8.256706724346833 24.936578105742306 1.0691412475434152 0.8555821663744904 0.1869030487014951 0.1708746708930193 594.9295772755619 3134755.9096427513 0.12801313260007638 0.04478276941643776 5.537239083967196e-09 8.256706724346833 -0.21355908116892486 TPS(ph)SSSTLAYSPR ddPTM_A459_Selumetinib_30min_R1 2 TPSSSSTLAYSPR 13 0 H3BR17;Q6Q0C0;A0A087WUB0 H3BR17 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 T(0.042)PS(0.879)S(0.017)S(0.057)S(0.003)T(0.003)LAYSPR;T(0.36)PS(0.575)S(0.044)S(0.015)S(0.005)T(0.002)LAYSPR 164.92 0.00036256 30722000.0 1934.24 1830.46 1650.28 1670.78 1558.7 1473.48 1720.93 1541.03 960.28 1511.24 True False 1979.3040286241292 1616.1488922422336 1426.1810403391648 1379.0096374249124 1417.7158602108368 1458.6581290127967 1591.1188645713091 1500.156878429097 1629.5250239237585 1705.2223747241703 1.1607307398510374 0.9477643011244531 0.8363607359831048 0.8086978319458042 0.8313964684167134 0.8554063978011919 0.9330858474271908 0.879742666214872 0.9556085165650865 1.0 10.7357441752266 -4.795008661589201 3.0784367304498104 0.8791944863490931 1.2000126296739244 0.6663584426972906 0.05764054404541425 0.20244506708297214 2.8942058770270545 0.014954320890068533 0.1580559658998455 1.6032134158087924e-05 4.795008661589201 0.3208181433248313 TPS(ph)SSSTLAYSPR ddPTM_A459_Selumetinib_30min_R2 1 TPSSSSTLAYSPR 13 0 H3BR17;Q6Q0C0;A0A087WUB0 H3BR17 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 T(0.13)PS(0.813)S(0.052)S(0.004)S(0.001)T(0.001)LAYSPR 91.845 0.019245 16575000.0 34746.0 36031.0 41525.0 50956.0 57845.0 33787.0 47089.0 54429.0 47159.0 40982.0 True False 32814.956419258495 38794.4618420747 38853.32670900151 44015.704895997034 50577.99395913877 38440.85256215131 49278.73180508336 54587.379378793965 56592.11773255411 39798.7431759764 0.8245224296194984 0.9747660038041626 0.9762450672677128 1.1059571580281988 1.270843999658487 0.9658810679568206 1.2381981910129598 1.3715855080505253 1.4219574091152367 1.0 15.2804352514637 -5.4017917016689365 0.5542824761628862 1.2634175188475125 0.7253334454511458 0.47874261593846 0.13667457626608845 1.934702515132905 0.7294317122610062 0.08793117869826585 0.6183697050876507 3.964681445489352e-06 5.4017917016689365 -0.5380840733963668 TPS(ph)TASLTGTPPTASLTR ddPTM_A459_Selumetinib_30min_R1 1 TPSTASLTGTPPTASLTR 18 0 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 T(0.225)PS(0.752)T(0.023)ASLTGTPPTASLTR 142.4 0.00030179 8973700.0 373.42 782.22 619.42 984.9 440.54 579.21 807.53 653.79 294.15 766.65 True False 382.1199594511655 690.6373187557876 535.3061662305099 812.9057038627445 400.6932347836543 573.3836732806025 746.6173619538674 636.4493653907837 499.1510661340166 865.056995303383 0.4417280728620115 0.7983720408082188 0.6188102854919674 0.9397134619755909 0.46319865275828176 0.6628276245306955 0.8630845898102034 0.735731135458393 0.5770152358099364 1.0 9.756651379324872 -14.522878745280336 0.345386534521639 4.4657350607325395 0.6779345508501142 0.2776376135606444 0.15436769857957305 567.5489371718847 4.715067472223014 1454.4786575916517 0.11719545380592433 3.0000000000000132e-15 14.522878745280336 -3.787800509882425 TPS(ph)TEAAHIMLR ddPTM_A459_Selumetinib_30min_R2 1 TPSTEAAHIMLR 12 0 G3V1L9;Q07157 G3V1L9 TJP1 Tight junction protein ZO-1 1 T(0.004)PS(0.983)T(0.014)EAAHIMLR 115.82 0.0034158 4022100.0 13175.0 12311.0 12794.0 13873.0 15326.0 11434.0 13227.0 14658.0 9927.6 12278.0 True False 12442.786243703764 13255.214113895858 11970.847969053959 11983.473467740148 13400.610863821608 13008.929712482266 13842.081708803276 14700.65235323747 11913.397400320291 11923.5022379249 1.0435512985544788 1.1116879797057615 1.0039707906439155 1.0050296656652187 1.1238821108447894 1.091032605429046 1.160907377093953 1.232913959329779 0.9991525277218912 1.0 13.54152043407147 -6.277381933774397 24.15441707912793 1.115425990376176 1.0434555690503704 0.12798438359580078 0.0714650063318278 893.2481635346187 1353348.2106348614 0.021932648955182443 0.02496070382787886 5.279807228084867e-07 6.277381933774397 -0.07197042132580567 TPS(ph)TPVACSTPAQLK ddPTM_A459_Selumetinib_30min_R2 1 TPSTPVACSTPAQLK 15 0 Q6PL18;A0A0B4J211 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 T(0.027)PS(0.508)T(0.465)PVACSTPAQLK 184.87 2.121e-05 22389000.0 51527.0 41973.0 46363.0 62637.0 57178.0 51745.0 51203.0 51119.0 45188.0 51830.0 True False 48663.33561892403 45192.19413553332 43380.05505621765 54105.73254514812 49994.78846219444 58872.404055658095 53584.04095681968 51267.747826793995 54226.86265821279 50333.53322948752 0.9668173977982333 0.897854595851376 0.8618519756686537 1.0749440596284365 0.9932699982385773 1.1696457665159128 1.0645793672483115 1.0185604812014106 1.077350608608664 1.0 15.619232252841195 -5.768609557537304 24.999999414613008 1.0600461196029447 0.907742644216628 0.62117229655528 0.05294642851282984 100.0851900855487 348964.43457477354 0.01483232918137573 0.022528165736334767 1.703689482933135e-06 5.768609557537304 -0.15230347538631672 TPS(ph)TSDMAEEGR ddPTM_A459_Selumetinib_30min_R2 1 TPSTSDMAEEGR 12 0 Q9HCH0 Q9HCH0 NCKAP5L Nck-associated protein 5-like 1 T(0.096)PS(0.867)T(0.036)S(0.001)DMAEEGR 107.53 0.0084425 2330000.0 15122.0 20196.0 10357.0 12623.0 9404.3 9351.1 8011.4 6261.3 6590.3 13704.0 True False 14281.579778162302 21744.968259624788 9690.64189584898 10903.725624110424 8222.84775849129 10639.129144165903 8383.945974287937 6279.519346385981 7908.544148367255 13308.329912731948 1.073130879066896 1.6339366699063864 0.7281636358126378 0.8193158492170334 0.6178722508693276 0.7994338293332774 0.6299773171588644 0.4718487885078974 0.5942551920659277 1.0 13.700041915653133 -5.3105653945022775 9.516014372465875 0.6895277029104013 1.3529641325968003 0.6556962607003869 0.1868614548607524 0.2471576519774924 46.857135636411 0.04700846208949708 0.09834317115060938 4.891416064037534e-06 5.3105653945022775 0.6634364296863989 TPS(ph)TVTLNNNSAPANR ddPTM_A459_Selumetinib_30min_R2 2 TPSTVTLNNNSAPANR 16 0 Q9ULH0-2;Q9ULH0-4;Q9ULH0;Q9ULH0-5 Q9ULH0-2;Q9ULH0-5 KIDINS220 Kinase D-interacting substrate of 220 kDa 1 T(0.112)PS(0.867)T(0.019)VT(0.001)LNNNSAPANR;TPS(0.522)T(0.138)VT(0.339)LNNNS(0.001)APANR 178.02 1.1333e-06 10342900.0 27125.2 14206.7 23209.9 24069.1 23233.0 14176.0 31614.0 21396.3 22640.2 21725.7 True False 25617.689974779 15296.308208259625 21716.600303028416 20790.8470584866 20314.262834344736 16128.615323084527 33084.11364195259 21458.559690651855 27168.872620042235 21098.422590852344 1.2141993016049493 0.7249977168857948 1.0292997123132843 0.9854218707089932 0.9628332519584855 0.7644465008525054 1.5680846991991186 1.0170693850807433 1.287720563139249 1.0 14.364847520404943 -7.236581111931345 24.999862712313785 1.219641240643658 0.943006722660332 0.3184967383546191 0.1944019324292493 873.529850315379 878506.8172869626 0.06938942356446662 0.05372613261082575 5.799878397457459e-08 7.236581111931345 -0.27663451798332606 TPS(ph)VSAPLALSCPR ddPTM_A459_Selumetinib_30min_R2 1 TPSVSAPLALSCPR 14 0 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 T(0.308)PS(0.688)VS(0.004)APLALSCPR 90.229 0.02802 0.0 5191.2 5479.5 5478.7 5948.3 6671.2 4738.4 6055.3 8762.5 7737.0 11097.0 True False 4902.693886020113 5899.760030630517 5126.206406757533 5138.131278610163 5833.104214715298 5391.0715890874535 6336.88344834932 8787.997424290039 9284.616189842262 10776.600776531404 0.45493880562940475 0.5474602013167862 0.4756793457470429 0.4767858979985283 0.5412749656105162 0.5002571498081089 0.5880224738536647 0.8154702588062815 0.8615533211605748 1.0 13.395614565414284 -7.907375229452581 1.2343745201152947 0.9779270489396593 0.4938473604022087 0.9617621334023543 0.035843125148511 0.07614365419879121 0.20892293318703783 0.030271443049142383 0.010888330999391184 1.2377267313171723e-08 7.907375229452581 -0.4840796885374506 TPSKPPAQLSPS(ph)VPK ddPTM_A459_Selumetinib_30min_R2 1 TPSKPPAQLSPSVPK 15 1 F5H8D7;P18887;M0QYS5 F5H8D7 XRCC1 DNA repair protein XRCC1 1 TPSKPPAQLS(0.107)PS(0.893)VPK 73.928 0.02295 10428000.0 70015.0 52673.0 71374.0 67864.0 70038.0 59060.0 62559.0 64387.0 53270.0 57129.0 True False 66123.8465922519 56712.84972961065 66781.87454613554 58620.80612807016 61239.20029233581 67194.97890669943 65468.117458306835 64574.35551015838 63925.48848816041 55479.53733103203 1.1918600942489486 1.0222300411631007 1.2037208267917845 1.0566203135093755 1.103815987630491 1.2111668939444176 1.180040797162304 1.1639310386613342 1.1522354288344832 1.0 15.759668135974323 TPSNGAEGLT(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TPSNGAEGLTPR 12 0 Q99459 Q99459 CDC5L Cell division cycle 5-like protein 1 TPSNGAEGLT(1)PR;TPSNGAEGLT(1)PR 126.56 0.006354 35669000.0 86264.0 87381.0 106012.0 103261.0 110038.0 92951.0 89181.0 79671.0 85766.0 93310.0 True False 81469.79222215276 94082.84172580088 99191.30333713836 89196.67366483949 96214.04268779875 105754.15652483293 93328.09320879914 79902.82941975584 102921.59650226332 90615.8978515044 0.8990673176980523 1.0382597751222185 1.0946346688490225 0.9843380221317164 1.0617788375883914 1.1670596333784182 1.0299306790706781 0.8817749568701018 1.1358006590733638 1.0 16.46747656160307 -4.7628849121006995 6.322558416829372 1.0440548887141137 0.8946842025599573 0.2439683716964529 0.07646097633547054 0.18402904689360539 32.36221449424187 0.01913336905515754 0.11892681441051854 1.7262952990852697e-05 4.7628849121006995 -0.14937068615415638 TPSNTPSAEADWS(ph)PGLELHPDYK ddPTM_A459_Selumetinib_30min_R1 4 TPSNTPSAEADWSPGLELHPDYK 23 0 Q9Y3Z3-3;Q9Y3Z3-4;Q9Y3Z3;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y586;A0A2R8YF51;A0A2R8Y5D2;A0A2R8YCS7 Q9Y3Z3-3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 TPSNTPSAEADWS(1)PGLELHPDYK;TPSNTPSAEADWS(1)PGLELHPDYK;T(0.001)PS(0.001)NT(0.001)PS(0.004)AEADWS(0.995)PGLELHPDYK;TPSNTPSAEADWS(1)PGLELHPDYK 154.88 4.2309e-09 178907000.0 15865.259999999998 17444.9 17204.02 19201.0 18649.42 15585.69 17554.0 16589.7 9422.529999999999 14615.64 True False 16234.88968957795 15402.44299808602 14867.808578917406 15847.905797409452 16962.58325382252 15428.912109274275 16229.887647193515 16149.68726505986 15989.345215637457 16491.699762389533 0.9844279197104197 0.9339512130345934 0.9015328191230157 0.9609625463563012 1.0285527567332307 0.9355562089761652 0.9841246130497052 0.9792615374850774 0.9695389466222438 1.0 14.009452481320121 -5.997547981698693 24.999738554897508 0.9808890850047802 0.9380151974728566 0.30701113686415016 0.028871588461081295 95.37467999845317 972367.56341578 0.008046580286517606 0.01185370290333866 1.0056619493765048e-06 5.997547981698693 -0.04287388753192367 TPSNTPSAEADWS(ph)PGLELHPDYK ddPTM_A459_Selumetinib_30min_R2 4 TPSNTPSAEADWSPGLELHPDYK 23 0 Q9Y3Z3-3;Q9Y3Z3-4;Q9Y3Z3;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y586;A0A2R8YF51;A0A2R8Y5D2;A0A2R8YCS7 Q9Y3Z3-3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 TPSNTPSAEADWS(1)PGLELHPDYK;T(0.001)PS(0.002)NT(0.005)PS(0.009)AEADWS(0.983)PGLELHPDYK;TPSNT(0.001)PS(0.001)AEADWS(0.998)PGLELHPDYK;T(0.002)PS(0.002)NT(0.013)PS(0.029)AEADWS(0.953)PGLELHPDY(0.001)K 109.05 1.143e-05 62653600.0 242883.0 227606.0 248441.0 290152.0 255447.0 207799.0 208881.0 230973.0 196163.0 236445.0 True False 229384.53519768492 245062.6483313603 232456.57654210797 250632.7970598814 223355.4641348452 236421.42603849046 218594.3803898494 231645.09319036163 235401.0812521684 229618.21849211224 0.9989822963702014 1.0672613433754108 1.0123612057816451 1.0915196481610672 0.9727253595189697 1.0296283439138865 0.95199057733896 1.008827151049075 1.025184686119559 1.0 17.808877588077095 -6.2828503034565415 24.987616831028042 0.9977757225268085 1.042142583225949 0.3125936580042281 0.032304043911072444 951.3798887876505 1110303.8263217693 0.009487951684752659 0.010767364933463952 5.213743921694675e-07 6.2828503034565415 0.04436686069914053 TPSPKEEDEEPES(ph)PPEK ddPTM_A459_Selumetinib_30min_R1 3 TPSPKEEDEEPESPPEK 17 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 TPSPKEEDEEPES(1)PPEK;TPSPKEEDEEPES(1)PPEK;TPSPKEEDEEPES(1)PPEK 126.09 0.00065794 213921000.0 13421.5 14104.2 17155.5 18395.800000000003 11044.1 13040.3 11575.5 12239.4 7419.4 11604.7 True False 13734.194836307162 12452.873707135308 14825.877328416125 15183.318861933485 10045.163104994223 12909.126421645062 10702.350715511488 11914.77135282577 12590.179908464132 13094.276284350315 1.0488700969844091 0.9510165691263455 1.1322410652152912 1.1595386054347958 0.76714152709606 0.9858602446836611 0.8173304490529539 0.9099220983343512 0.9615025401221557 1.0 13.676648704237438 -6.2521030454880195 24.98974644518589 0.9019191663345296 1.0684468995620944 0.47727272707409263 0.08493585467485301 599.2171695784456 1603871.1554362597 0.02504894901510277 0.0318983085236002 5.59624803001902e-07 6.2521030454880195 0.16652773322756476 TPSPKEEDEEPES(ph)PPEK ddPTM_A459_Selumetinib_30min_R2 4 TPSPKEEDEEPESPPEK 17 1 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 TPSPKEEDEEPES(1)PPEK;TPSPKEEDEEPES(1)PPEK;TPSPKEEDEEPES(1)PPEK;TPSPKEEDEEPES(1)PPEK 140.63 0.00027685 178669000.0 325452.0 303436.0 322245.0 289066.0 245879.0 192132.0 212999.0 199725.0 132187.0 280648.0 True False 307364.68072758085 326708.5654994808 301512.10753382725 249694.71213333585 214989.4818338503 218596.43899935638 222903.87554951172 200306.16668374633 158628.09361337466 272544.9630289257 1.1277577002769985 1.1987327223684798 1.10628391067285 0.9161597020849558 0.788822069740592 0.8020564261030072 0.8178609249360976 0.7349472338715997 0.5820254091305264 1.0 18.056134732171422 -5.883582212613817 1.8638424687247004 0.7733697952908546 1.169460440653441 0.7280501212301589 0.09762034433281351 0.16703520447462458 1.18207546144891 0.030517281003269555 0.054963430189550855 1.307428017356995e-06 5.883582212613817 0.3960906453625864 TPSPKEEDEEPES(ph)PPEKK ddPTM_A459_Selumetinib_30min_R1 4 TPSPKEEDEEPESPPEKK 18 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 TPSPKEEDEEPES(1)PPEKK;TPSPKEEDEEPES(1)PPEKK;TPSPKEEDEEPES(1)PPEKK;TPSPKEEDEEPES(1)PPEKK 101.89 0.0027493 510903000.0 12483.5 12995.1 17505.1 18445.4 10881.97 14556.0 12351.3 12171.61 9135.29 12502.039999999999 True False 12774.341261337438 11473.627650741904 15128.003568631462 15224.257153040799 9897.697734867848 14409.579855790547 11419.631496911315 11848.779363838716 15501.919914817006 14106.798614182111 0.9055450219935016 0.8133402882215262 1.072390978447987 1.079214183842907 0.7016260744601053 1.0214634978416746 0.8095126193572167 0.839933969988533 1.0988970877653506 1.0 13.784103000547901 -8.265917211195173 24.977939118604656 1.0494485489993115 0.9075542511989488 0.19158288829877845 0.11831116097522315 684.9213042487806 3820504.743496801 0.10193155650478876 0.02978345753980228 5.4210422094108806e-09 8.265917211195173 -0.14189429780036267 TPSPKEEDEEPES(ph)PPEKK ddPTM_A459_Selumetinib_30min_R2 2 TPSPKEEDEEPESPPEKK 18 2 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 TPSPKEEDEEPES(1)PPEKK;TPSPKEEDEEPES(1)PPEKK 85.969 0.008403299999999999 337520000.0 67312.0 66693.0 63905.0 52867.0 45441.0 34533.6 40116.3 39752.6 21304.3 53355.0 True False 63571.06851128561 71808.13864820551 59793.421874503154 45666.4233993382 39732.29533230573 39290.289935191286 41981.78743894042 39868.27348460282 25565.755291877547 51814.50251706166 1.2268972087564232 1.3858694990762535 1.1539900794148157 0.8813444341051234 0.7668180413239043 0.758287506905111 0.8102323750983909 0.7694423674428768 0.49340925898997423 1.0 15.661068334239502 -5.745666393164409 2.1268567488960874 0.7569368516735577 1.3100792840325113 0.7709872176147676 0.12106188911377391 0.1340430059412626 1.23618380354068 0.0352536106984373 0.06898534039162302 1.7961127956950418e-06 5.745666393164409 0.5531424323589536 TPSPS(ph)PPCSSSPSPSGR ddPTM_A459_Selumetinib_30min_R1 1 TPSPSPPCSSSPSPSGR 17 0 O75385 O75385 ULK1 Serine/threonine-protein kinase ULK1 1 T(0.001)PS(0.098)PS(0.894)PPCS(0.002)S(0.002)S(0.002)PS(0.001)PSGR 80.87100000000002 0.016105 5547000.0 138.03 340.67 254.47 316.17 214.23 284.09 283.01 285.13 0.0 125.74 True False 141.24583044037382 300.78419802681367 219.9143717036548 260.9568447459478 194.85293432537844 281.2323125330816 261.6623278473419 277.56742616723113 0.0 141.87995381131864 0.9955305640161956 2.1199908087566506 1.5500031244449903 1.839279177472707 1.3733647995438931 1.982184973834168 1.844251571968495 1.9563540775912478 0.0 1.0 7.148526955494603 -8.253738408597856 24.997138039143085 0.499999971831313 1.7230650807763117 0.6102776857257783 0.38585703040150443 310.2048377144678 1006924.4274281078 0.24974320992531918 0.09045974730518135 5.575214633215521e-09 8.253738408597856 1.2230651089449986 TPSS(ph)PCPASK ddPTM_A459_Selumetinib_30min_R1 2 TPSSPCPASK 10 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 T(0.004)PS(0.434)S(0.562)PCPASK;T(0.001)PS(0.417)S(0.551)PCPAS(0.03)K 117.95 0.0058645 84290000.0 18270.7 21419.0 19537.5 19912.6 19525.7 18038.4 19164.8 17639.1 10202.4 16477.7 True False 18696.371761406488 18911.253522577055 16884.41481180554 16435.23821579581 17759.603882542324 17856.950073556767 17719.183706331005 17171.253768128252 17312.72764618627 18592.773301389883 1.005571974569757 1.017129247800992 0.908117069901743 0.8839584041272213 0.9551885345267305 0.9604242349484189 0.9530145621151862 0.9235445132246427 0.9311535920728984 1.0 14.18245435850777 -5.2505740844503865 24.93684377392147 0.9365118921808964 1.0113506233148337 0.47549545438700014 0.030092326015443534 578.6536322145073 1328056.092657897 0.007831125085658652 0.0202986382245656 5.615984694873336e-06 5.2505740844503865 0.07483873113393735 TPSS(ph)PCPASK ddPTM_A459_Selumetinib_30min_R2 2 TPSSPCPASK 10 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 TPS(0.141)S(0.856)PCPAS(0.002)K;TPS(0.012)S(0.987)PCPASK 112.84 0.0076823 79525000.0 398043.0 337630.0 338147.0 412173.0 423506.0 328003.0 344550.0 357441.0 334146.0 345911.0 True False 375921.36355237814 363525.1353484408 316390.99016661645 356034.3263619155 370301.3900883224 373182.4359352212 360572.25771287264 358481.09413245734 400984.53681931354 335923.650645288 1.1190678680416133 1.0821659464885311 0.941853869350519 1.059866805085013 1.1023379549995869 1.110914445048336 1.073375622764983 1.0671505070983776 1.193677599207581 1.0 18.35777384627452 -6.133667178780349 5.341589878055431 1.0944244502891443 1.0437412905587242 0.09256556929691595 0.061559254187247954 0.5022857792243897 19.75654874714229 0.01833354527546194 0.023946974892663193 7.350769779987653e-07 6.133667178780349 -0.050683159730420035 TPSS(ph)PLQSCTPS(ph)LSPR ddPTM_A459_Selumetinib_30min_R1 1 TPSSPLQSCTPSLSPR 16 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 2 T(0.372)PS(0.088)S(0.539)PLQS(0.001)CT(0.03)PS(0.506)LS(0.464)PR 127.91 0.01816 7530500.0 1478.4 1820.1 1697.4 1793.3 1507.4 1980.7 1585.0 1329.0 758.37 1434.3 True False 1512.8438435343664 1607.001845858466 1466.9024031507981 1480.1338194101545 1371.0559361530852 1960.7759563317097 1465.4421739091788 1293.750602799601 1286.8985008466911 1618.4063762651047 0.9347737785275221 0.9929532343829751 0.9063869400564638 0.9145625234287261 0.8471641957548108 1.2115473499657807 0.9054846764080783 0.7993978655628312 0.7951640080759849 1.0 10.660358193672357 -7.5215319262796605 24.998554077436065 0.8488567836230888 0.9666776197717825 0.16079823618458144 0.10510814725828989 85.52645308123465 1587573.0329036978 0.04874631688375154 0.028641610088096906 3.0093179368254626e-08 7.5215319262796605 0.11782083614869365 TPSS(ph)PLQSCTPS(ph)LSPR ddPTM_A459_Selumetinib_30min_R2 1 TPSSPLQSCTPSLSPR 16 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 2 T(0.035)PS(0.035)S(0.93)PLQSCT(0.001)PS(0.992)LS(0.007)PR 189.44 1.7507e-05 7889000.0 21660.0 23795.0 24279.0 32368.0 30630.0 24501.0 24029.0 28944.0 18759.0 26836.0 True False 20456.22391184999 25619.999987015843 22716.915572976486 27959.422562085594 26781.985564325696 27875.79035206647 25146.396112560204 29028.22224806284 22511.32417025346 26061.174951698376 0.7849309921660643 0.9830715627557006 0.8716765692674977 1.072838143863637 1.0276584081095064 1.0696290709736338 0.9648987875322729 1.1138493295817848 0.8637877690463233 1.0 14.66961450792122 -3.875395145076495 0.8805810328043309 1.0156683562594473 5.044147375348363e-18 0.404817637333469 0.0773563761797075 8.847176069800645 1.643514997043858 0.024823867573537252 12.65116341268495 0.0001332308672605126 3.875395145076495 -1.0156683562594473 TPSS(ph)PLQSCTPSLSPR ddPTM_A459_Selumetinib_30min_R2 2 TPSSPLQSCTPSLSPR 16 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 T(0.399)PS(0.147)S(0.454)PLQSCTPSLSPR;T(0.004)PS(0.254)S(0.742)PLQSCTPSLSPR 225.37 9.7794e-12 40432000.0 57384.0 57689.0 56923.0 71708.0 69922.0 47637.0 56692.0 56349.0 46630.0 51047.0 True False 54194.827006352694 62113.56080062855 53260.636153076324 61941.246696800365 61137.773249388876 54198.56434436922 59328.29033306684 56512.9662609209 55957.30295105918 49573.1404739658 1.0932296499313787 1.2529680429112326 1.0743849520900755 1.2494920859276586 1.2332842475754877 1.093305040313767 1.1967829708957842 1.1399916511361563 1.1287826919185426 1.0 15.597271036435183 -9.020760193769753 0.7915663835626492 0.9983163625451499 1.174640680859716 0.39262017039042485 0.06268210261119497 1.6501801330176589 1.668167153859299 0.06296302202848954 0.020565714706499625 9.533224188106522e-10 9.020760193769753 0.1763243183145662 TPSS(ph)SPPITPPASETK ddPTM_A459_Selumetinib_30min_R2 1 TPSSSPPITPPASETK 16 0 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 T(0.004)PS(0.08)S(0.539)S(0.378)PPITPPASETK 145.52 0.00037312 9170500.0 18952.0 21305.0 24679.0 24994.0 25834.0 16911.0 21841.0 19966.0 21299.0 21838.0 True False 17898.72371086707 22939.02499362775 23091.180008463532 21589.774082945103 22588.50196110972 19240.336747226484 22856.649777120467 20024.097754450766 25559.39514378318 21207.480198061894 0.8439816302411447 1.081647832717255 1.0888224245789364 1.0180263700030778 1.0651195592380671 0.9072429429397659 1.0777635798150733 0.944199761944407 1.2052066018724372 1.0 14.372285594396276 -8.246996369910676 24.997290807539674 1.1026033293093782 1.010634503112778 0.15657583716543133 0.09089404430971579 1306.5001565826392 2261239.015486225 0.05849980355789822 0.021908325094493895 5.662440220198462e-09 8.246996369910676 -0.0919688261966003 TPSSPLQSCTPS(ph)LSPR ddPTM_A459_Selumetinib_30min_R2 2 TPSSPLQSCTPSLSPR 16 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 TPSSPLQSCT(0.005)PS(0.651)LS(0.344)PR;TPSSPLQS(0.004)CT(0.025)PS(0.97)LS(0.001)PR 131.48 0.00069898 27143000.0 16238.5 10979.3 16882.1 16721.4 15325.2 13863.0 14473.400000000001 15345.6 13157.8 15774.3 True False 15336.029177865928 11821.377005986247 15795.924065840682 14443.916473976087 13399.91136697369 15772.502414215638 15146.441778498012 15390.25315539917 15789.72765964929 15318.854972446537 1.0011211154782966 0.7716880293761462 1.0311426078680312 0.9428848631282057 0.874733221972244 1.0296136651587249 0.988745033864565 1.004660804158082 1.030738112479666 1.0 13.90302084474253 -6.773107213648031 24.999111085460065 1.009667429042375 0.9228013868543421 0.2939696981717914 0.06694703242689289 287.3419346094214 615645.5599119379 0.02275454854978007 0.02022975193904158 1.686136719881189e-07 6.773107213648031 -0.08686604218803295 TPSSPLQSCTPSLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TPSSPLQSCTPSLSPR 16 0 R4GNJ5;A0A590TQL1;Q96AP0-2;Q96AP0 R4GNJ5 ACD Adrenocortical dysplasia protein homolog 1 TPSSPLQSCT(0.055)PS(0.086)LS(0.858)PR 144.4 0.00038931 8146400.0 648.05 822.2 1022.5 1109.6 1004.8 707.72 676.55 667.19 574.31 723.68 True False 663.1483041142087 725.9364417695898 883.6501161904627 915.8291897716541 913.9160174118482 700.6009793583461 625.51728880647 649.4939538614491 974.5621240572066 816.5713772401392 0.8121130896793466 0.8890054954205243 1.0821468163347057 1.121554361686039 1.1192114282779737 0.8579788600063945 0.7660289182809752 0.7953915260373429 1.193480632827282 1.0 9.673435188347556 -6.786870760458908 24.942644453768356 0.9000037572080847 1.0091556512112596 0.06356213237030639 0.14495596896453478 538.8812554700231 528520.9344523341 0.054171756242577244 0.04779139095237639 1.6335379920409328e-07 6.786870760458908 0.10915189400317493 TPSSPS(ph)KSPASFEIPASAMEANGVDGDGLNKPAK ddPTM_A459_Selumetinib_30min_R2 1 TPSSPSKSPASFEIPASAMEANGVDGDGLNKPAK 34 2 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y911;Q4VXL4;O95359-2;H0YA73 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 T(0.214)PS(0.059)S(0.214)PS(0.256)KS(0.256)PAS(0.001)FEIPASAMEANGVDGDGLNKPAK 94.031 3.383e-10 13813000.0 57859.0 61157.0 59503.0 63538.0 58197.0 41322.0 47575.0 42201.0 34050.0 64958.0 True False 54643.42840792836 65847.54524925104 55674.64176196791 54884.01479083646 50885.77257221883 47013.73041623159 49787.33176807409 42323.79792324838 40860.95143649075 63082.493758847166 0.866221754276554 1.0438323110841838 0.8825688149679353 0.8700355918180408 0.806654422489159 0.7452738091800315 0.7892416548781656 0.6709277867968333 0.6477383660940021 1.0 15.944952073007117 -6.1017225055413915 1.2744386759481634 0.7494489308134556 0.9529447578119096 0.32727411205055146 0.09983541839662956 0.4468923921653073 1.4752307369414326 0.036499964923653136 0.06141205705326059 7.911839971860868e-07 6.1017225055413915 0.20349582699845392 TPSSS(ph)PPITPPASETK ddPTM_A459_Selumetinib_30min_R1 2 TPSSSPPITPPASETK 16 0 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 T(0.26)PS(0.107)S(0.107)S(0.518)PPIT(0.008)PPASETK;T(0.001)PSS(0.022)S(0.976)PPIT(0.001)PPASETK 150.76 0.00022067 13560000.0 4285.6 4626.8 5075.6 5460.2 5247.1 4314.2 4281.2 5041.0 2572.8900000000003 3172.82 True False 4385.446141674026 4085.092105059035 4386.361398275125 4506.678570648144 4772.500731450744 4270.803064980189 3958.265637186107 4907.296304524299 4366.006413549381 3580.08235288395 1.2249567773605297 1.1410609316761309 1.225212429748068 1.2588198053650277 1.3330700975652798 1.1929343082121635 1.105635358917794 1.3707216261579027 1.219526810614378 1.0 11.805777058947923 -10.728111191010685 6.290506709786959 0.9999976904850848 1.2306843821910056 0.45922755997131093 0.07494450931257825 2.480401798690565e-06 3.133472609659495e-07 0.07414676852445327 0.01798305306031958 1.8702032569776308e-11 10.728111191010685 0.23068669170592082 TPSSS(ph)PPITPPASETK ddPTM_A459_Selumetinib_30min_R2 2 TPSSSPPITPPASETK 16 0 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 TPSS(0.068)S(0.922)PPIT(0.009)PPASETK;TPS(0.002)S(0.395)S(0.603)PPITPPASETK 135.86 0.00041134 7508400.0 94812.0 92501.0 107345.0 121224.0 115950.0 92252.8 100343.0 98044.0 91143.0 114665.0 True False 89542.72860250779 99595.52926240607 100438.53956839905 104713.08207693615 101383.32439384802 104959.78581246146 105009.14832588233 98329.29180794209 109374.14674819598 111354.32351455107 0.804124400170299 0.8944019964289178 0.9019725179801787 0.9403593751189455 0.9104570096068151 0.9425748592397132 0.9430181515328446 0.8830307499923257 0.9822173337877058 1.0 16.764798048655102 -3.4037165151318676 0.7132498142595782 0.940165108225142 6.107719290602514e-21 0.6431622471409673 0.03137681250000902 11.150295603970573 0.9234195318590792 0.011560684833270761 13.127904631072587 0.0003947148673561693 3.4037165151318676 -0.940165108225142 TPST(ph)PVACSTPAQLK ddPTM_A459_Selumetinib_30min_R2 1 TPSTPVACSTPAQLK 15 0 Q6PL18;A0A0B4J211 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 T(0.001)PS(0.053)T(0.945)PVACS(0.001)TPAQLK 154.13 0.00045407 20435000.0 55367.0 43853.0 51808.0 63914.0 62121.0 47815.0 55229.0 59629.0 47136.0 58996.0 True False 52289.92379166195 47216.38409038055 48474.72968428543 55208.80294220023 54316.804611213774 54401.08222864606 57797.25793418732 59802.510517887655 56564.5170898804 57292.63218998351 0.9126814704248101 0.8241266334877071 0.8460901137085526 0.9636283206386249 0.9480591576085764 0.9495301603223777 1.0088078645528182 1.0438080470728128 0.9872912960659816 1.0 15.806062000444044 -6.244493861030528 0.8887290489491964 1.0110513867529654 0.8527646103936314 0.7333548916258443 0.034387441094643485 0.31241457029577646 0.5265439063023091 0.01779824634063889 0.029711284971472345 5.695162744680983e-07 6.244493861030528 -0.15828677635933397 TPT(ph)IRRS(ph)ILGT(ph)T(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TPTIRRSILGTTPR 14 2 E7EWZ1;P10243-2;P10243 E7EWZ1 MYBL1 Myb-related protein A 4 T(0.06)PT(0.972)IRRS(0.973)ILGT(0.997)T(0.998)PR 82.663 0.017634 4901700.0 186.32 148.02 110.58 149.35 145.65 116.93 118.88 0.0 0.0 0.0 True False 190.6608934843907 130.68974958736888 95.563843372461 123.26882614671632 132.47598321659603 115.75379036394544 109.91278588916293 0.0 0.0 0.0 0.0 TPT(ph)SPLSPSSQK ddPTM_A459_Selumetinib_30min_R2 1 TPTSPLSPSSQK 12 0 Q5VT06 Q5VT06 CEP350 Centrosome-associated protein 350 1 T(0.259)PT(0.64)S(0.097)PLS(0.003)PSSQK 103.46 0.024961 2840600.0 24574.0 19858.0 20719.0 24527.0 26951.0 19712.0 17967.0 20660.0 18160.0 23540.0 True False 23208.275457516236 21381.04474646609 19385.96209714154 21186.38028856504 23565.174435003017 22427.149072280077 18802.501100935082 20720.117179552875 21792.50743279508 22860.339035734814 1.0152200901849064 0.9352899234365544 0.848017261110511 0.9267745441328287 1.0308322373594905 0.9810505888483289 0.8224944114583513 0.9063783851658374 0.9532888991160401 1.0 14.48055917949494 -10.166248441385516 15.711254922481247 0.9999999953701819 0.9326140094211859 0.08554009401603246 0.0626551208601139 0.0 0.0 0.0643177448212496 0.015599344441149146 6.819484688476639e-11 10.166248441385516 -0.06738598594899603 TPT(ph)SSPASSPLVAK ddPTM_A459_Selumetinib_30min_R2 1 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 T(0.353)PT(0.619)S(0.026)S(0.002)PASSPLVAK 222.81 1.0399e-08 4929900.0 34238.0 29022.0 36869.0 37972.0 36554.0 32781.0 34930.0 39058.0 31669.0 37973.0 True False 32335.18902557341 31247.894079561807 34496.88867993203 32800.148094646356 31961.759723093768 37296.28519371005 36554.31421248193 39171.652313599996 38003.68490579225 36876.62082429727 0.8768479405864759 0.8473632719344282 0.935467727487729 0.8894564458854916 0.866721489351725 1.0113802284491389 0.9912598658822074 1.0622354065530477 1.0305631062798568 1.0 15.170418840539403 -6.7865283819659465 7.848243379487952 1.0216601224617343 0.8843963382847028 0.8587432798360275 0.027552501294018723 0.07092993670001796 17.277814149627627 0.010051726266405124 0.009039438861258233 1.6348263086468193e-07 6.7865283819659465 -0.13726378417703156 TPTCQSSTDCS(ph)PYAR ddPTM_A459_Selumetinib_30min_R1 1 TPTCQSSTDCSPYAR 15 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 TPTCQSS(0.001)T(0.001)DCS(0.998)PYAR 146.1 0.00034997 3011800.0 490.74 648.0 651.34 625.01 440.34 485.02 456.05 361.78 359.73 422.48 True False 502.1732871861847 572.1318587529728 562.8916055545194 515.8637363907543 400.5113247483411 480.14113916292507 421.64978133203863 352.184419172942 610.4355363603257 476.7094233036895 1.0534159020940381 1.2001689725115714 1.1807855646183172 1.0821345481608435 0.8401581868735032 1.0071987581773674 0.8845006218042077 0.7387821636338445 1.2805191307733925 1.0 8.896966333787583 -6.054038243159871 5.769549457209833 0.9445937689241304 1.1480305809021705 0.2739000919244433 0.1376773779049929 0.2470522424434856 18.404899843622392 0.039275866027127446 0.052039525713394465 8.830021414777466e-07 6.054038243159871 0.2034368119780401 TPTCQSSTDCS(ph)PYAR ddPTM_A459_Selumetinib_30min_R2 3 TPTCQSSTDCSPYAR 15 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 TPTCQSS(0.016)T(0.016)DCS(0.969)PYAR;TPTCQSS(0.001)T(0.002)DCS(0.998)PYAR;TPTCQS(0.001)S(0.013)T(0.013)DCS(0.842)PY(0.131)AR 155.2 0.00027124 0.0 9977.3 9358.2 8931.3 12914.699999999999 13680.300000000001 10096.8 9489.099999999999 9410.1 8979.7 10429.599999999999 True False 9422.801608296442 10075.943848644323 8356.66988166418 11155.69558089986 11961.658410566268 11487.542550375267 9930.36195229493 9437.481833074078 10775.890913781388 10128.470348644847 0.9303282019833508 0.9948139750433734 0.8250673195466552 1.101419582315552 1.180993575418493 1.134183361845183 0.9804404426798343 0.9317776039435984 1.0639208629586563 1.0 13.306128687246407 -5.7770991179193745 24.999836429437078 1.0585667280077642 0.9245442172275018 0.39150220647567036 0.07940245037127026 270.9343853075487 432529.89767866273 0.024881549135036197 0.03704991404048241 1.6707092690901567e-06 5.7770991179193745 -0.1340225107802624 TPTGEGLLDS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 TPTGEGLLDSPSK 13 0 O95425-3;O95425;A0A6I8PIX7;A0A0J9YWY6;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 TPTGEGLLDS(0.944)PS(0.056)K;TPTGEGLLDS(0.76)PS(0.24)K 108.06 0.006404099999999999 10478900.0 3302.6 4004.9 4599.6 4406.1 3504.8 3539.4 3364.1 3169.2 2294.63 3167.8 True False 3379.5441542590647 3536.004446172503 3974.9995837942815 3636.65734774052 3187.7914588226963 3503.796849518074 3110.3432285475524 3085.1425209875815 3893.819516855682 3574.417986985008 0.9454809612542494 0.9892532040314326 1.1120690412447147 1.017412446161063 0.8918351100598539 0.9802426191553208 0.8701677419576497 0.863117445195567 1.0893576327764865 1.0 11.803492635463002 -6.192238238376226 9.69605491927491 0.939914096611603 1.0211662878106635 0.1541080703328772 0.07460958242219393 0.8543881679189671 115.85105771471704 0.022097801768654845 0.028544922029852055 6.423352585680975e-07 6.192238238376226 0.08125219119906057 TPTGEGLLDS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 TPTGEGLLDSPSK 13 0 O95425-3;O95425;A0A6I8PIX7;A0A0J9YWY6;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 TPTGEGLLDS(0.958)PS(0.042)K;TPTGEGLLDS(0.999)PS(0.001)K 199.33 0.00010612 26441000.0 151201.0 140086.0 138622.0 140770.0 154936.0 126708.0 144322.0 119662.0 92673.0 133340.0 True False 142797.85372555995 150830.14575251535 129703.21144022167 121596.88315820515 135471.55453458612 144160.8768592969 151033.25896861777 120010.19660888946 111210.18949996783 129490.12774107383 1.1027701973628137 1.1648003472057162 1.0016455594172702 0.9390436574543206 1.0461921452844085 1.1132962749682234 1.166368908606077 0.9267903175511552 0.8588314139464112 1.0 16.982482586233523 -7.8411934187225185 9.306361097521199 0.9183039966880195 1.07172768768056 0.4580557902174771 0.07330426756812797 0.31201009464540075 33.41769051313301 0.043646864870676885 0.020938996996267886 1.4414732296079972e-08 7.8411934187225185 0.15342369099254038 TPTGNAPSSES(ph)DIDISSPNVSHDESIAK ddPTM_A459_Selumetinib_30min_R2 1 TPTGNAPSSESDIDISSPNVSHDESIAK 28 0 O95251;O95251-4 O95251 KAT7 Histone acetyltransferase KAT7 1 T(0.004)PT(0.005)GNAPS(0.026)S(0.259)ES(0.701)DIDIS(0.004)SPNVSHDESIAK 101.02 3.528199999999999e-07 3733300.0 7726.7 7627.2 8241.0 8958.7 10801.0 9516.4 7992.6 7381.0 7289.4 8995.6 True False 7297.280946430802 8212.181714686574 7710.783032122372 7738.509605380498 9444.08181783487 10827.197718721898 8364.271737036444 7402.477488009674 8747.483682853324 8735.8736546243 0.8353235446082734 0.9400527113094738 0.8826573433832459 0.8858312186422418 1.0810689567191352 1.2393949531299098 0.9574625352564309 0.847365447426223 1.0013290059687252 1.0 13.09273627563081 -6.244767653965316 23.722798075241137 1.021204279320013 0.8895931510773748 0.3227188024236717 0.09584997005518481 607.462466139776 864378.440454239 0.0318012294639758 0.04091519059834218 5.691573466033153e-07 6.244767653965316 -0.1316111282426381 TPTHQPPKPGS(ph)PGRPACPLSNLLLQSYEER ddPTM_A459_Selumetinib_30min_R1 2 TPTHQPPKPGSPGRPACPLSNLLLQSYEER 30 2 Q96F63 Q96F63 CCDC97 Coiled-coil domain-containing protein 97 1 T(0.011)PT(0.046)HQPPKPGS(0.942)PGRPACPLSNLLLQSYEER;TPTHQPPKPGS(0.986)PGRPACPLS(0.009)NLLLQS(0.002)Y(0.002)EER 76.16199999999998 1.6933e-05 128458000.0 3816.9 4468.5 5066.0 5631.6 5004.5 4267.37 4398.9 4819.5 2071.21 3591.04 True False 3905.826343605471 3945.3259426507075 4378.065025546098 4648.146778224627 4551.843858616237 4224.44413226195 4067.08743142529 4691.6712040576995 3514.692094806858 4051.9849636917247 0.9639291306863365 0.9736773403660804 1.0804741539705234 1.1471283383020616 1.1233614881110259 1.0425616506762896 1.0037271776348857 1.1578698455443337 0.8674000832433139 1.0 11.984413105186224 -10.270742378689008 11.41159747212936 0.9999999621124838 1.047329047653228 0.012510223392381947 0.08702706475586766 0.0 0.0 0.08393867211521489 0.020358118306183462 5.361145836931994e-11 10.270742378689008 0.04732908554074422 TPTHQPPKPGS(ph)PGRPACPLSNLLLQSYEER ddPTM_A459_Selumetinib_30min_R2 1 TPTHQPPKPGSPGRPACPLSNLLLQSYEER 30 2 Q96F63 Q96F63 CCDC97 Coiled-coil domain-containing protein 97 1 T(0.003)PT(0.003)HQPPKPGS(0.912)PGRPACPLS(0.048)NLLLQS(0.017)Y(0.018)EER 42.885 0.020897 6796400.0 12536.0 10636.0 14115.0 15009.0 17123.0 11255.0 8752.3 10125.0 8957.5 13686.0 True False 11839.299305584089 11451.746999869738 13206.856267250012 12964.748308030852 14971.855658437784 12805.274087282472 9159.299292353437 10154.462073716013 10749.250293461564 13290.849619501563 0.8907857394016688 0.8616264067171956 0.993680362455662 0.9754642238226648 1.1264784484860693 0.963465425753775 0.6891432492708417 0.7640190329756231 0.8087707408628919 1.0 13.698145711602427 -7.182591441533377 8.994017529634696 0.7959893832630281 0.9727354432591809 0.3593834214489401 0.09870524396760649 0.40134457510019156 43.1843538684287 0.038677375594349986 0.029941827252178803 6.567628192503205e-08 7.182591441533377 0.17674605999615278 TPTS(ph)PLSPSSQK ddPTM_A459_Selumetinib_30min_R2 1 TPTSPLSPSSQK 12 0 Q5VT06 Q5VT06 CEP350 Centrosome-associated protein 350 1 TPTS(0.95)PLS(0.035)PS(0.011)S(0.003)QK 122.52 0.0035218000000000007 3202800.0 21811.0 24067.0 27003.0 23895.0 28003.0 19583.0 19138.0 25446.0 19375.0 21458.0 True False 20598.831936350885 25912.86151239798 25265.65637864343 20640.459778825847 24485.012790003675 22280.38049322547 20027.954921227574 25520.04364718793 23250.541382731542 20838.451785420457 0.9885010723667474 1.2435118395181266 1.2124536236574184 0.9904987180125764 1.1749919352038678 1.0691955776107058 0.9611057062905247 1.2246612133173411 1.1157518620936462 1.0 14.346960474609826 -5.740181616433985 24.997410939798172 1.0849403475227906 1.1576911043504956 0.09144004570462139 0.09964285788576037 591.6627070978498 695742.0951209448 0.026686454621916895 0.046167083943055506 1.8189400419258961e-06 5.740181616433985 0.07275075682770504 TPTS(ph)SPASSPLVAK ddPTM_A459_Selumetinib_30min_R1 1 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 T(0.26)PT(0.013)S(0.478)S(0.247)PAS(0.002)SPLVAK 182.33 7.5843e-05 64470000.0 2284.9 2599.6 2450.3 2930.4 2157.9 2151.4 2397.7 2458.2 1551.4 1831.1 True False 2338.133724358548 2295.2376234787466 2117.562718534465 2418.660650420742 1962.718326008189 2129.7588693149078 2216.8395586006554 2393.000550641068 2632.6124902271417 2066.139521424412 1.131643676583187 1.110882203103299 1.0248885404769768 1.1706182594838994 0.9499447184743246 1.0307914094042574 1.0729379771373568 1.1581989143653355 1.2741697561702894 1.0 11.012721963875096 -7.759782944391021 6.189726749158583 1.1629019840550485 1.0675168743474024 0.12534195895911848 0.08516922560560342 0.24115740888420986 36.79450275821912 0.04288285310936953 0.02232887678629078 1.7386695795824096e-08 7.759782944391021 -0.09538510970764613 TPTSS(ph)PAS(ph)SPLVAK ddPTM_A459_Selumetinib_30min_R2 1 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 2 T(0.001)PT(0.008)S(0.376)S(0.615)PAS(0.994)S(0.006)PLVAK 168.93 0.0034056 6483100.0 50366.0 53171.0 52901.0 60228.0 58720.0 56810.0 52621.0 52315.0 47767.0 60090.0 True False 47566.85935107279 57249.04472828821 49497.4072542538 52024.84250090493 51343.068636539516 64635.061830165956 55067.98076653339 52467.22798878555 57321.73472149351 58355.04556743015 0.8151284758420513 0.9810470400907504 0.8482112690162976 0.8915226094852318 0.8798394061266187 1.1076173654166572 0.9436712837950146 0.8991035390103305 0.9822926906167414 1.0 15.83256978099036 TPTSS(ph)PASSPLVAK ddPTM_A459_Selumetinib_30min_R1 1 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 T(0.016)PT(0.012)S(0.219)S(0.74)PAS(0.011)S(0.003)PLVAK 156.2 0.00032265 16332000.0 7504.2 7196.3 8810.3 8326.4 7907.9 7001.9 7175.7 7267.7 4292.3 6386.4 True False 7679.033259368642 6353.75385053089 7613.909651513772 6872.350545885629 7192.631841253136 6931.467243216536 6634.431171810783 7074.936987183346 7283.719602811624 7206.156648803923 1.0656211949879284 0.8817118694728188 1.0565839770881926 0.953677651043889 0.998123159374695 0.9618812886016043 0.9206615252961459 0.9817906176599204 1.0107634287995355 1.0 12.815014298346883 -6.767774394132136 24.932274306273072 0.9704839215724965 0.9866181696115837 0.015344926397381276 0.053420242199806026 800.7637829791711 3151500.016198726 0.01767129778860466 0.01596416464064353 1.7069688893047353e-07 6.767774394132136 0.01613424803908714 TPTSS(ph)PASSPLVAK ddPTM_A459_Selumetinib_30min_R2 3 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 TPT(0.042)S(0.029)S(0.639)PAS(0.145)S(0.145)PLVAK;TPT(0.002)S(0.055)S(0.604)PAS(0.26)S(0.079)PLVAK;T(0.001)PT(0.001)S(0.021)S(0.81)PAS(0.129)S(0.038)PLVAK 211.82 3.2836e-06 124743400.0 246434.0 227111.0 237591.0 270023.0 278850.0 225491.0 257039.0 238414.0 217294.0 244284.0 True False 232738.18483346445 244529.6834230362 222304.65372952126 233245.40158434308 243818.37004937077 256550.33844650481 268991.8228131159 239107.7452684378 260758.87170163964 237230.88619394458 0.9810619037320157 1.0307666398173996 0.9370814116833818 0.9831999758819633 1.0277682386181397 1.0814373396420478 1.1338819625417815 1.0079115291630232 1.0991775813224427 1.0 17.85593232773563 -6.4894011060579055 3.245258296742428 1.0689105721401597 0.9836234860218028 0.44396875313858397 0.04270832862771969 0.22611350896476917 4.848020369316903 0.014108929409688546 0.01534408262212845 3.2404020178499284e-07 6.4894011060579055 -0.08528708611835689 TPTSSPAS(ph)SPLVAK ddPTM_A459_Selumetinib_30min_R2 2 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 TPTS(0.001)S(0.421)PAS(0.55)S(0.027)PLVAK;T(0.001)PTSS(0.023)PAS(0.924)S(0.052)PLVAK 213.99 1.5491e-06 18853900.0 70262.0 60159.0 71145.0 82007.0 74127.0 76134.0 73360.0 69868.0 64727.0 79006.0 True False 66357.11932107124 64773.00185832679 66567.60815681911 70837.50513003439 64814.50355621199 86620.7674243592 76771.3853600823 70071.3043127299 77674.20862348711 76724.89149775967 0.8648708134440155 0.8442240919978118 0.8676142364927666 0.9232662796545344 0.8447650076912072 1.1289786890984197 1.0006059814672268 0.91327994011925 1.012373000563385 1.0 16.227407080022836 -6.7291198768998255 24.999994018126845 1.0049750480705715 0.8705180440623704 0.6418287849938671 0.05297245493174562 136.71871542130157 105755.23911634012 0.018175024054690687 0.018173658619242864 1.8658645911848673e-07 6.7291198768998255 -0.13445700400820104 TPTSSPASS(ph)PLVAK ddPTM_A459_Selumetinib_30min_R2 2 TPTSSPASSPLVAK 14 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 TPTSS(0.008)PAS(0.431)S(0.56)PLVAK;T(0.003)PT(0.001)S(0.014)S(0.008)PAS(0.291)S(0.683)PLVAK 176.56 7.0589e-10 3407400.0 32022.0 34845.0 32955.0 41673.0 39896.0 35469.0 36022.0 35073.0 31397.0 40216.0 True False 30242.34543422253 37517.49945566573 30834.71117869105 35997.065510065266 34883.90780523467 40354.53279447552 37697.09437623887 35175.05662335226 37677.27730547725 39054.8595862834 0.7743555028640804 0.9606358812474746 0.7895230326092537 0.921705157601128 0.8932027454398114 1.0332781431545226 0.9652344106616275 0.900657613315456 0.9647269944022542 1.0 15.2532144532645 -6.274199619486293 1.973912996515763 0.9641042270452355 0.8559326452475647 0.4274876421841931 0.06065468135878249 0.3486312834163295 2.6691064351817544 0.020190616352872462 0.02608660956336188 5.318637367729678e-07 6.274199619486293 -0.10817158179767072 TPTVPDS(ph)PGYMGPTR ddPTM_A459_Selumetinib_30min_R2 2 TPTVPDSPGYMGPTR 15 0 A0A087WXN9;Q765P7 A0A087WXN9 MTSS1L MTSS1-like protein 1 TPTVPDS(1)PGYMGPTR;TPTVPDS(0.996)PGY(0.004)MGPTR 190.18 2.7123e-05 32242000.0 37504.0 37809.0 39622.0 42718.0 47489.0 39508.0 40591.0 54605.0 61937.0 99801.0 True False 35419.6778204073 40708.82872490362 37072.76365717179 36899.7347073397 41523.00726295342 44949.86838208406 42478.56192954062 54763.89150965563 74326.13066437384 96919.48581586116 0.36545466086873074 0.42002728741511236 0.38251094034492616 0.38072565487446025 0.42842785342303225 0.46378566707921887 0.4382871160732972 0.5650452130307666 0.7668853176293899 1.0 16.56449913047083 -8.366808269736762 1.0726672128366723 1.0026107415300078 0.4000595367894567 0.9850853952526657 0.02392444586940377 0.05316224778697553 0.13064935720542473 0.02339047881746166 0.007743972318429595 4.2972609832913255e-09 8.366808269736762 -0.6025512047405511 down TPVAS(ph)THSISSAATPDR ddPTM_A459_Selumetinib_30min_R1 2 TPVASTHSISSAATPDR 17 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 TPVAS(0.996)T(0.004)HSISSAATPDR;T(0.006)PVAS(0.938)T(0.055)HSISSAATPDR 146.67 0.00042081 16231700.0 2235.19 2454.3 2688.3999999999996 3473.3 2535.4 2561.5 2330.3 1899.77 998.41 1559.0 True False 2287.2655780773703 2166.949415026886 2323.3300463241476 2866.753356915903 2306.073517661227 2535.7336356559167 2154.523594864707 1849.38192827735 1694.2288490187439 1759.1128359459665 1.3002381264800382 1.2318421938303945 1.3207396358260168 1.6296585974112916 1.3109298451688753 1.4414843572512055 1.224778508142775 1.0513151234456437 0.9631155059519925 1.0 10.780632310188654 -7.66142725443682 2.3762360544388383 0.9876389881621792 1.3725507679129691 0.7204040223057436 0.10269880483991564 0.1694055431051332 1.9164155182332947 0.0669884719470685 0.03176780416053 2.180583620566826e-08 7.66142725443682 0.38491177975078994 TPVAS(ph)THSISSAATPDR ddPTM_A459_Selumetinib_30min_R2 1 TPVASTHSISSAATPDR 17 0 J3KNR0;P27448-8;P27448-3;P27448-4;P27448-2;P27448;H0YIY6;P27448-6;P27448-7;A2SY06 J3KNR0 MARK3 MAP/microtubule affinity-regulating kinase 3 1 TPVAS(0.5)T(0.5)HSISSAATPDR 193.64 8.7036e-08 4010700.0 5082.9 4515.9 5323.2 4091.9 5615.9 4598.1 3970.5 3988.4 3503.7 5790.0 True False 4800.412766460859 4862.255009092866 4980.711107461936 3534.5761610787804 4910.380435217001 5231.44653760405 4155.136117396494 4000.0055836848333 4204.5379015574945 5622.827655773348 0.8537364223731704 0.864734846372261 0.8858018442638721 0.6286118617648871 0.8732937830977573 0.9303942531890623 0.7389762539013849 0.7113868374709563 0.7477621863868446 1.0 12.457080112445732 -7.351510936713434 24.999274808846568 0.7754803422734332 0.8346743185728692 0.011920588245727948 0.106590173771086 211.55853899534026 58710.002167920415 0.04440487103941965 0.029937762680837973 4.451322531410468e-08 7.351510936713434 0.05919397629943601 TPVDES(ph)DDEIQHDEIPTGK ddPTM_A459_Selumetinib_30min_R1 2 TPVDESDDEIQHDEIPTGK 19 0 A0A087WX60;Q86TC9-2;Q86TC9 A0A087WX60 MYPN Myopalladin 1 T(0.024)PVDES(0.975)DDEIQHDEIPTGK;T(0.123)PVDES(0.877)DDEIQHDEIPTGK 99.414 0.00090297 4530700.0 3617.3 3780.6000000000004 3904.7 4074.0 4555.6 3209.7 3323.8999999999996 3178.6 2052.66 2921.5 True False 3701.5760519594583 3337.965594446743 3374.463186981807 3362.5523784514403 4143.546784356505 3177.413332174425 3073.1755469127565 3094.293202452079 3483.214099645252 3296.502982819845 1.1228796307028097 1.0125777564415945 1.0236493655756607 1.0200362007787709 1.2569522326996636 0.9638739442172292 0.932253228020424 0.9386593061126872 1.0566391469379754 1.0 11.686720671435907 TPVDES(ph)DDEIQHDEIPTGK ddPTM_A459_Selumetinib_30min_R2 3 TPVDESDDEIQHDEIPTGK 19 0 A0A087WX60;Q86TC9-2;Q86TC9 A0A087WX60 MYPN Myopalladin 1 T(0.136)PVDES(0.864)DDEIQHDEIPTGK;T(0.128)PVDES(0.872)DDEIQHDEIPTGK;T(0.276)PVDES(0.724)DDEIQHDEIPTGK 82.177 0.0034992 14720000.0 91822.0 86984.0 96246.0 107978.0 116799.0 101765.0 94776.0 106960.0 87673.0 108809.0 True False 86718.90083258958 93655.3931023568 90053.63714472136 93271.21012756057 102125.66542369164 115782.2050193072 99183.27179508125 107271.23589181891 105210.04978829551 105667.40145026633 0.820677897273786 0.8863224780486049 0.8522366965473852 0.8826867023077104 0.9664822265148475 1.0957230274447654 0.9386364236633857 1.0151781383808085 0.9956717809306016 1.0 16.689170846240934 -6.292554456985377 3.126460639264625 1.0074301954802787 0.8585515151120872 0.7612277190063332 0.03943285470300524 0.12228908367496069 2.4341149941227282 0.012324659023776774 0.014994652064599347 5.098536620762446e-07 6.292554456985377 -0.14887868036819152 TPVEPEVAIHR ddPTM_A459_Selumetinib_30min_R1 4 TPVEPEVAIHR 11 0 P60866;P60866-2;E5RIP1;E5RJX2 P60866 RPS20 40S ribosomal protein S20 0 ;;; 198.62 2.7268e-05 42703000.0 18242.7 20624.6 17262.7 19338.0 19335.9 17605.399999999998 18059.2 17624.2 10957.4 16772.1 False True 18667.719415885007 18209.862243883585 14918.520157223566 15960.981319217946 17586.971259030404 17428.305660424234 16696.98000445467 17156.74896453028 18593.90750316802 18924.96240908872 0.9864072124613483 0.9622139188576825 0.7882985358036401 0.8433824582685924 0.9293001951002162 0.9209162630650344 0.882272822715671 0.9065671357048903 0.9825069715455967 1.0 14.20800281411844 -8.291608603895863 3.5170806569946325 0.9983940604802556 0.89886815531864 0.30722949918583775 0.053557820408566464 0.30667293906841747 7.553611767456326 0.052979545442097514 0.014886994857409288 5.10965286117722e-09 8.291608603895863 -0.09952590516161564 TPVEPEVAIHR ddPTM_A459_Selumetinib_30min_R2 3 TPVEPEVAIHR 11 0 P60866;P60866-2;E5RIP1;E5RJX2 P60866 RPS20 40S ribosomal protein S20 0 ;; 172.27 0.00036131 32775200.0 197332.0 169924.0 180539.0 204033.0 213882.0 164960.0 171602.0 196674.0 162572.0 192996.0 False True 186365.0774225843 182956.62440822326 168923.31729600028 176243.3534234433 187012.23103066004 187681.74264221368 179581.83302291206 197246.28877886664 195090.94264120923 187423.70401617122 0.9943516931375148 0.9761658770356895 0.9012911050003862 0.9403471900664002 0.9978045840697094 1.0013767662281405 0.95815966270423 1.0524084443547648 1.0409085855243607 1.0 17.51594390077409 -7.172124976973868 0.9850758870027633 1.0295326654751953 0.955227757211704 0.39578799702282275 0.033158801665184964 0.5708150227040917 1.0997327492566418 0.02508810132902247 0.01545516431745246 6.727830215756806e-08 7.172124976973868 -0.07430490826349123 TPVKPSS(ph)VEEEDSFFR ddPTM_A459_Selumetinib_30min_R2 2 TPVKPSSVEEEDSFFR 16 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 TPVKPS(0.012)S(0.987)VEEEDSFFR;TPVKPS(0.004)S(0.969)VEEEDS(0.027)FFR 77.357 0.015341 20789600.0 20436.0 16183.9 16537.9 17421.9 16650.8 13632.5 14082.6 15686.099999999999 13156.3 13479.4 True False 19300.248931789763 17425.1530905596 15473.869519104066 15049.007165546172 14558.977643959332 15510.253131486312 14737.468804142503 15731.743954026351 15787.927617735786 13090.21469831283 1.4744027792208276 1.331158693127126 1.182094402248304 1.1496379175114528 1.112203121147876 1.1848738534048182 1.1258385858286943 1.2017941887579568 1.2060862240686288 1.0 13.676201139296397 -4.9905996691455545 1.6861855727144666 1.147706608368769 1.5211368905653633 0.7885692469958021 0.056077173053549395 0.27038448576851565 1.0362527544391396 0.015129258559117814 0.14480669047806827 1.021881015378064e-05 4.9905996691455545 0.37343028219659424 TPVKPSSVEEEDS(ph)FFR ddPTM_A459_Selumetinib_30min_R1 1 TPVKPSSVEEEDSFFR 16 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 TPVKPS(0.004)S(0.432)VEEEDS(0.564)FFR 67.418 0.027782 7173500.0 1702.1 1985.2 2199.7 2247.5 1645.7 1759.2 1786.7 1782.2 1080.4 1637.9 True False 1741.7556182899382 1752.7718611055589 1900.9928220871977 1855.0163158001003 1496.846725571933 1741.5040452257995 1651.9277805195768 1734.9302665985322 1833.3598907060748 1848.140419497048 0.9424368407915339 0.9483975582237184 1.02859761197395 1.0037204404116238 0.8099204528946367 0.9423007185242621 0.8938323966580048 0.9387437492821434 0.9920024860475724 1.0 10.851858659822904 -1.6273854806839094 18.915108457366085 0.9462589290216226 0.010611958522264486 0.0 0.06040704308216 0.0 0.0 0.014322745658708322 0.0 0.023583839973610164 1.6273854806839094 -0.9356469704993581 TPVQYSQQQNS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 4 TPVQYSQQQNSPQK 14 0 P46013 P46013 MKI67 Antigen KI-67 1 TPVQYS(0.001)QQQNS(0.999)PQK;TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK 212.43 2.7943e-06 86881000.0 13656.5 32714.899999999998 17157.3 23707.3 17155.5 18489.2 20103.1 14252.7 8271.86 17196.7 True False 13974.669879076768 28884.62429925559 14827.432898302808 19567.265096136925 15603.788054049532 18303.215434850426 18586.706981901334 13874.672096705712 14036.74226724912 19404.06395504297 0.7201929405847406 1.4885863273888402 0.7641405909945618 1.008410668067889 0.8041505166238243 0.9432671154484398 0.9578770212757822 0.7150394952754106 0.723391878101962 1.0 14.24407121926961 TPVQYSQQQNS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 7 TPVQYSQQQNSPQK 14 0 P46013 P46013 MKI67 Antigen KI-67 1 TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK;TPVQYSQQQNS(1)PQK;TPVQY(0.004)S(0.06)QQQNS(0.936)PQK 218.83 9.9416e-09 213026700.0 264792.2 304624.0 276495.0 206111.0 232102.0 159640.9 191345.0 164414.4 139799.5 259616.0 True False 250076.1095711617 327987.6812794584 258705.61272499387 178038.32623869326 202943.27174179317 181629.98489919596 200242.9216429246 164892.8186837308 167763.3063243961 252120.2115166243 0.9918923519333641 1.3009178411617808 1.026120084418283 0.7061644331000165 0.8049464599485769 0.7204102511520368 0.7942358942123964 0.6540245928393491 0.6654099856382761 1.0 17.94375225263321 -5.631814507461397 4.164913223691891 0.7507880875210621 1.1507306703448197 0.6504360122480981 0.11666854471281732 0.11306771819350686 3.518526476199379 0.03025218240847518 0.05473258462493972 2.334454923918332e-06 5.631814507461397 0.3999425828237576 TPVS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 TPVSPVK 7 0 P23443-3;P23443-5;P23443-2;P23443 P23443-3 RPS6KB1 Ribosomal protein S6 kinase beta-1 1 T(0.004)PVS(0.996)PVK 91.265 0.028563 163950000.0 557240.0 418510.0 471210.0 468500.0 448210.0 374830.0 431060.0 475000.0 329040.0 383040.0 True False 526270.8316084613 450608.3712782509 440892.8616146555 404689.49179242173 391901.8527517603 426459.430132038 451105.144129186 476382.1713595169 394857.1941457534 371980.6399425606 1.4147801662197406 1.2113758698512687 1.1852575491099107 1.0879315973404204 1.053554434478837 1.146455982757301 1.2127113502435058 1.2806638846394736 1.0614993140684024 1.0 18.5048680114 -4.5755471100882925 1.53828730247858 1.1363603461563334 1.64546580135678 0.5491374505697599 0.0786629323566026 1.5455787533775152 2.3413421272470694 0.02287830792056749 1.3861496161891425 2.6573752751708003e-05 4.5755471100882925 0.5091054552004466 TPVSGSLKS(ph)PVPR ddPTM_A459_Selumetinib_30min_R1 1 TPVSGSLKSPVPR 13 1 A0A0C4DG98;Q8NI27;Q8NI27-2;H0Y7U4;H7C477 A0A0C4DG98 THOC2 THO complex subunit 2 1 TPVS(0.001)GS(0.061)LKS(0.939)PVPR 141.06 0.0040284 78500000.0 1777.9 2514.6 2800.9 3208.4 2517.8 2399.2 2108.7 2181.5 1124.6 1792.8 True False 1819.3216108088154 2220.1894629941744 2420.5531642424144 2648.1131691270502 2290.065434553693 2375.0662262993073 1949.639061275891 2123.6395334893373 1908.3640624658015 2022.9233433508182 0.8993527198095643 1.0975153706598688 1.1965619815494108 1.309052652850727 1.1320574465072781 1.1740762368015347 0.9637730800251 1.049787447690277 0.9433694404379861 1.0 10.982225936113899 -7.261620682605812 24.997955157198593 0.9933814422736598 1.143683487196146 0.33543042450172256 0.09981698377205869 20.63862128724059 2845304.918602061 0.04260127961958228 0.03078162882841626 5.4749394112719124e-08 7.261620682605812 0.15030204492248633 TQASSS(ph)FQDSSQPAGK ddPTM_A459_Selumetinib_30min_R1 1 TQASSSFQDSSQPAGK 16 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 TQASS(0.025)S(0.975)FQDSSQPAGK 244.27 6.1932e-22 4077700.0 840.51 1732.1 1226.0 1593.8 1146.9 1198.5 1432.1 1014.2 644.25 1115.8 True False 860.0922476522396 1529.3049267685553 1059.5159339359484 1315.4727493313453 1043.1630975016417 1186.4441781509329 1324.0755440096746 987.300121414113 1093.245195841714 1259.0237988123856 0.6831421681333976 1.2146751540448408 0.8415376539628326 1.0448354912529907 0.8285491493374776 0.9423524632894821 1.0516683999608674 0.7841790777469142 0.8683276653491001 1.0 10.298089838651583 -7.768689821912189 24.994557504492036 0.8696900818322325 0.9497012068264509 0.030279822385297583 0.14540929499597663 528.4047045906703 1821540.404756789 0.07161283481196151 0.0355184776944808 1.703374643713509e-08 7.768689821912189 0.08001112499421836 TQASSS(ph)FQDSSQPAGK ddPTM_A459_Selumetinib_30min_R2 2 TQASSSFQDSSQPAGK 16 0 P46087-2;P46087;P46087-4 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 1 TQAS(0.003)S(0.025)S(0.94)FQDS(0.033)SQPAGK;TQASS(0.063)S(0.937)FQDSSQPAGK 282.67 9.130399999999999e-63 8704100.0 46682.0 50504.0 46767.0 51674.0 49324.0 41204.0 44798.0 45006.0 38148.0 49205.0 True False 44087.60132285227 54377.49440404489 43758.06213605956 44635.91205737799 43127.47815784529 46879.476987328955 46881.19576555298 45136.96000885561 45778.66594417768 47784.32380005659 0.9226373382895932 1.1379776897456169 0.9157409513453811 0.93411203733148 0.9025444900780246 0.9810639402052904 0.9810999097050622 0.9445976508472043 0.9580268653738585 1.0 15.54424978258332 -5.315367734567162 24.999997642689255 0.949820550822444 1.0303091469346817 0.23660447590896383 0.05603223965526033 352.12354515368986 163235.95810461667 0.013712325452572475 0.028544555732593374 4.837625729286805e-06 5.315367734567162 0.08048859611223769 TQDPSS(ph)PGTTPPQAR ddPTM_A459_Selumetinib_30min_R1 2 TQDPSSPGTTPPQAR 15 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TQDPS(0.08)S(0.913)PGT(0.006)T(0.001)PPQAR;TQDPS(0.008)S(0.915)PGT(0.077)TPPQAR 244.0 1.6030000000000002e-20 178322000.0 5598.0 6367.2 6930.2 6691.7 6315.3 5308.6 5727.8 5583.6 2956.0 4646.799999999999 True False 5728.42250818817 5621.72526396903 5989.116904863709 5523.120213766198 5744.082230056777 5255.200303823151 5295.747434521767 5435.504789911101 5016.116102302069 5243.262043664984 1.0925302722776113 1.0721808708304619 1.14225015934496 1.0533748204401387 1.0955169095538329 1.0022768765052648 1.0100100644254844 1.036664722198729 0.9566785067251488 1.0 12.356248934206779 -6.762626612878597 24.9972229720489 1.0039728185362171 1.0908536166048228 0.7222295449389131 0.02789285783787864 17.326015402238692 364796.79279346036 0.009247694210888726 0.008619120154943927 1.7273223288514907e-07 6.762626612878597 0.08688079806860571 TQDPSS(ph)PGTTPPQAR ddPTM_A459_Selumetinib_30min_R2 1 TQDPSSPGTTPPQAR 15 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TQDPS(0.253)S(0.634)PGT(0.085)T(0.028)PPQAR 103.04 0.0059071 108610000.0 14191.0 14491.0 14986.0 16462.0 14284.0 11850.0 13874.0 13477.0 12115.0 13805.0 True False 13402.32103107402 15602.413104091045 14021.817075523111 14219.847201466033 12489.516219419806 13482.229936410246 14519.168490809443 13516.215838762546 14538.338521382842 13406.41378030243 0.9996947170738215 1.163802144240477 1.0459036477096413 1.0606749451787585 0.9316075442763232 1.0056552152835392 1.083001668361299 1.0081902632769282 1.0844315832429035 1.0 13.710635747044565 -5.77481561225989 2.828088336759133 1.0211142019172863 1.0830085639761962 0.13381598836639053 0.056418874372098395 0.45764466065318454 7.4806697357868615 0.01628289658000121 0.028571308770070417 1.6795169366927046e-06 5.77481561225989 0.06189436205890986 TQDPSSPGT(ph)TPPQAR ddPTM_A459_Selumetinib_30min_R1 2 TQDPSSPGTTPPQAR 15 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TQDPS(0.042)S(0.021)PGT(0.755)T(0.182)PPQAR;TQDPS(0.013)S(0.107)PGT(0.873)T(0.007)PPQAR 160.87 0.00029306 6546100.0 2894.9 3715.5 3849.0 3620.1 3597.2 3121.8 3556.9 3095.1000000000004 1926.0900000000001 3106.3 True False 2962.3455375051685 3280.487532710913 3326.326941043612 2987.91749269319 3271.833895137244 3090.397526367613 3288.6001693233816 3013.0078936983055 3268.434053952298 3505.023862924282 0.8451712893713794 0.9359387156850807 0.949016917182532 0.8524670899673521 0.9334697916742611 0.8817051316133575 0.9382532895452712 0.8596255008616455 0.9324998007931979 1.0 11.775208551096368 -8.538397241635899 22.40176880535766 1.000000001867287 0.902184978997911 0.4081998768883881 0.03683119646059258 649.1645201684642 937104.1542016815 0.03332643793040797 0.008604849267471399 2.8946946493887862e-09 8.538397241635899 -0.09781502286937604 TQDPSSPGT(ph)TPPQAR ddPTM_A459_Selumetinib_30min_R2 3 TQDPSSPGTTPPQAR 15 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TQDPS(0.001)S(0.182)PGT(0.788)T(0.028)PPQAR;TQDPSS(0.011)PGT(0.953)T(0.036)PPQAR;TQDPS(0.085)S(0.287)PGT(0.622)T(0.006)PPQAR 192.4 6.9865e-05 131876400.0 77198.0 72360.0 81455.0 86331.0 84315.0 67187.0 56757.0 71449.0 58715.0 77102.0 True False 72907.64420807926 77909.77932592819 76214.27398149835 74572.56887071814 73722.59591433634 76441.39938713892 59396.31296186187 71656.9047609813 70459.64063417196 74875.86492494578 0.9737135495017062 1.0405192568262625 1.0178750396792633 0.9959493482374907 0.9845975867956189 1.0209083990383605 0.7932637976389276 0.9570093758891318 0.9410193886214127 1.0 16.192213142769376 TQDPSSPGTT(ph)PPQAR ddPTM_A459_Selumetinib_30min_R1 1 TQDPSSPGTTPPQAR 15 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TQDPS(0.04)S(0.04)PGT(0.459)T(0.46)PPQAR 183.76 4.901e-05 7653400.0 1990.7 2014.1 2796.9 2694.8 2240.0 1807.2 2108.5 2517.6 1263.2 1718.5 True False 2037.079436772096 1778.2882356703124 2417.0963422719847 2224.2037676610066 2037.3923955041216 1789.0212088063133 1949.45414743691 2450.825069682675 2143.5581395223176 1939.0862146075328 1.0505357737197862 0.9170753844125669 1.2465130864545908 1.1470370687520879 1.0506971686746203 0.922610451938264 1.0053468137472554 1.2639072214634444 1.1054475677122841 1.0 10.921161233863167 -7.708064320842371 24.999934562928114 1.1385137049768472 1.0501300220280603 0.08366082682281162 0.10951311328064356 210.4247621265604 98558.58938089095 0.05391720094986798 0.031129069120674573 1.958554581840029e-08 7.708064320842371 -0.08838368294878696 TQDPSSPGTT(ph)PPQAR ddPTM_A459_Selumetinib_30min_R2 2 TQDPSSPGTTPPQAR 15 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 1 TQDPS(0.001)S(0.002)PGT(0.031)T(0.966)PPQAR;TQDPS(0.003)S(0.006)PGT(0.286)T(0.705)PPQAR 168.47 0.00015403 15197800.0 61310.0 62534.0 69521.0 78693.0 77292.0 60072.0 59655.0 75962.0 58006.0 75404.0 True False 57902.63564337593 67330.15672149812 65048.0945487416 67974.87764700317 67581.88796075292 68346.37272067818 62429.07570413998 76183.036843814 69608.82082305673 73226.89059687972 0.7907291320361379 0.9194731084808226 0.888308844176341 0.9282775370213474 0.9229107969748024 0.9333507426517779 0.8525430370629468 1.0403696814495118 0.9505909680947566 1.0 16.16008591612841 -1.5228787452803432 0.17608309334701788 1.005692633069217 0.3042966179321062 0.4933824942831857 0.04736104989273331 52.67587104100862 0.5845313535472703 0.11252933155528255 9.823654575980695 0.029999999999999614 1.5228787452803432 -0.7013960151371108 TQDPVPPETPS(ph)DSDHK ddPTM_A459_Selumetinib_30min_R2 1 TQDPVPPETPSDSDHK 16 0 J3KR33;A0JLT2 J3KR33 MED19 Mediator of RNA polymerase II transcription subunit 19 1 TQDPVPPET(0.092)PS(0.816)DS(0.092)DHK 118.84 0.0011447 8256400.0 65717.0 56793.0 81847.0 80088.0 97370.0 70815.0 63546.0 68245.0 61352.0 75586.0 True False 62064.71222599469 61148.840481722626 76581.05312827587 69179.87624049406 85137.51010115548 80569.12345543387 66501.01491401027 68443.58165143213 73624.11431810816 73403.63578398703 0.8455264042865582 0.8330492056506854 1.043286920468618 0.9424584423049195 1.1598541297286555 1.0976176124645038 0.9059635017223143 0.9324276777358632 1.0030036459606708 1.0 16.163563903075996 -5.2558796635336416 24.49259467791023 1.0104341855137424 0.8392877750331462 0.4703201340740244 0.07271061981577265 317.44141778811473 1398431.400576377 0.020302503314038906 0.05054538167376633 5.547794126907986e-06 5.2558796635336416 -0.1711464104805962 TQDPVPPETPSDS(ph)DHK ddPTM_A459_Selumetinib_30min_R2 1 TQDPVPPETPSDSDHK 16 0 J3KR33;A0JLT2 J3KR33 MED19 Mediator of RNA polymerase II transcription subunit 19 1 TQDPVPPET(0.002)PS(0.387)DS(0.612)DHK 128.01 0.0006547 8149700.0 30409.0 27803.0 34748.0 32933.0 37647.0 32741.0 32951.0 31162.0 25159.0 32352.0 True False 28718.989516871945 29935.400699264595 32512.351510761822 28447.468587406227 32917.447291549805 37250.77555679394 34483.28679116782 31252.676260853197 30191.503001194447 31417.91369940921 0.9140960087815119 0.9528131302947562 1.0348348340957214 0.905453775816475 1.047728617707954 1.1856540161511238 1.0975676845091165 0.9947406616449163 0.9609646041443602 1.0 14.939299761472148 -6.355110183512395 7.480687031625815 1.057470244929667 0.9580074715179029 0.3214788846181603 0.06727057176065952 0.3585665371375554 25.215096333730642 0.022683710760405415 0.025729544377635177 4.4145843208830717e-07 6.355110183512395 -0.09946277341176402 TQDVLAQDAAGDNLEMMAPSRGS(ph)AK ddPTM_A459_Selumetinib_30min_R1 1 TQDVLAQDAAGDNLEMMAPSRGSAK 25 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 TQDVLAQDAAGDNLEMMAPS(0.093)RGS(0.907)AK 119.47 4.2592e-08 5316600.0 1409.3 1366.4 1974.3 1541.4 1426.3 1312.6 1298.0 1203.9 959.19 1291.6 True False 1442.1339479795618 1206.4212527778743 1706.200904053625 1272.2234256615245 1297.2914168337168 1299.3964357454438 1200.090814974205 1171.9686611816705 1627.6753735342095 1457.3894412493967 0.9895323152219653 0.8277960705846947 1.170724073992828 0.8729467839226746 0.890147396513021 0.891591772911084 0.823452387541237 0.8041561356290331 1.1168431219995867 1.0 10.509170728217487 -4.4435754179351825 21.349303434861284 0.9253917483452239 4.155076158196917 0.016179415582520118 0.11922989193631352 1479.535268880352 403156.2841777584 0.028236894012438875 2802.4492530278358 3.601012111519888e-05 4.4435754179351825 3.2296844098516932 TQDVLAQDAAGDNLEMMAPSRGS(ph)AK ddPTM_A459_Selumetinib_30min_R2 1 TQDVLAQDAAGDNLEMMAPSRGSAK 25 1 Q9UPN4-2;Q9UPN4;I3L2J8;Q9UPN4-3 Q9UPN4-2 CEP131 Centrosomal protein of 131 kDa 1 TQDVLAQDAAGDNLEMMAPS(0.428)RGS(0.572)AK 63.90600000000001 0.0014544 5083000.0 29990.0 25140.0 34729.0 29348.0 30499.0 21715.0 21754.0 21993.0 19340.0 28657.0 True False 28323.275859482026 27068.157162159183 32494.57395007621 25350.751771876145 26667.442955480557 24706.04414085642 22765.60410473324 22056.995988862844 23208.540404749816 27829.59795017217 1.017739311584514 0.9726391739695156 1.167626424508773 0.9109277042832489 0.9582403239611148 0.887761446826923 0.8180356807703145 0.7925732893574334 0.8339516958277233 1.0 14.764332445981003 -6.423143349642881 1.3740598426617907 0.8467385250825157 1.0372272020026299 0.4678878367915841 0.07792648993328753 0.3377500350515098 1.301364380955655 0.031084430059794898 0.03778427484665189 3.77447584444451e-07 6.423143349642881 0.19048867692011417 TQEDEEEIST(ph)SPGVSEFVSDAFDACNLNQEDLRK ddPTM_A459_Selumetinib_30min_R1 2 TQEDEEEISTSPGVSEFVSDAFDACNLNQEDLRK 34 1 Q96A49 Q96A49 SYAP1 Synapse-associated protein 1 1 TQEDEEEIS(0.099)T(0.328)S(0.238)PGVS(0.328)EFVS(0.007)DAFDACNLNQEDLRK;TQEDEEEIS(0.032)T(0.572)S(0.392)PGVS(0.004)EFVSDAFDACNLNQEDLRK 122.06 2.0517e-19 60305000.0 4545.8 5136.8 6896.4 7370.0 5589.5 5193.9 5333.6 4678.4 2770.1 3900.1 True False 4651.708295412966 4535.38106796647 5959.906759213603 6082.967852034145 5083.930711906375 5141.654081683881 4931.282257894005 4554.313634415092 4700.657379900864 4400.715825191061 1.0570344644353418 1.0306007586321624 1.3543039350773913 1.3822678158888042 1.1552508532371892 1.1683676669716911 1.12056366595312 1.0349029147360047 1.0681574467937338 1.0 12.103522497834128 -7.467491625869455 1.5050689855782333 1.0304389725199306 1.2037617039965491 0.30987820992956483 0.10528134240410415 0.5788377440461225 2.527498087348002 0.07845279107403702 0.039133668822294874 3.408068962260762e-08 7.467491625869455 0.17332273147661859 TQEDEEEISTSPGVS(ph)EFVSDAFDACNLNQEDLRK ddPTM_A459_Selumetinib_30min_R1 1 TQEDEEEISTSPGVSEFVSDAFDACNLNQEDLRK 34 1 Q96A49 Q96A49 SYAP1 Synapse-associated protein 1 1 TQEDEEEIS(0.032)T(0.271)S(0.271)PGVS(0.394)EFVS(0.033)DAFDACNLNQEDLRK 87.704 1.0548e-08 6958800.0 1670.3 1577.6 1986.4 2323.4 1633.2 1392.6 1426.5 1590.9 998.75 1349.4 True False 1709.2147401619682 1392.8938585936567 1716.6577905141667 1917.6618056195557 1485.4773483648792 1378.5917083796323 1318.8979565182613 1548.7041640285072 1694.8058041861264 1522.608634269074 1.1225568420492205 0.9148075396684673 1.1274451962754342 1.259458118428526 0.9756133749221647 0.9054143509710382 0.8662094295500934 1.0171386981343111 1.1130935199245835 1.0 10.57232944910248 -6.467706763850757 24.997158477222886 0.9705520456153427 1.0968830298066503 0.27391940938532655 0.09983045883812534 442.87774082539494 200657.49837553035 0.03322934879278419 0.0376783630620374 3.4063811132734487e-07 6.467706763850757 0.12633098419130762 TQEISRPNS(ph)PSEGEGESSDSR ddPTM_A459_Selumetinib_30min_R1 1 TQEISRPNSPSEGEGESSDSR 21 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 TQEISRPNS(0.742)PS(0.227)EGEGES(0.015)S(0.015)DSR 79.663 0.0011794000000000002 5594300.0 916.85 930.37 1086.0 1115.0 1296.8 887.54 881.17 866.56 393.16 798.8 True False 938.2108211204579 821.4418478827216 938.5271649709953 920.2861811422075 1179.5046689686353 878.6121534218433 814.7026374659629 843.57601381642 667.1638047297303 901.3337609709027 1.0409138786833323 0.9113625645153658 1.0412648517237704 1.0210270834090243 1.308621423098688 0.9747911278452679 0.9038856334288176 0.9359196896249986 0.7401961777300694 1.0 9.815917620047479 -6.998202301123948 24.9939007151159 0.8967571833566671 1.0613318120231288 0.34278063601153785 0.11083407299174268 72.43691073641214 1007091.1021445469 0.040734700283160744 0.035674816552101085 1.0041479335951181e-07 6.998202301123948 0.16457462866646166 TQGTSLRS(ph)PVSFSPTDHSLSTSSGSSIFTPEYDDSR ddPTM_A459_Selumetinib_30min_R2 1 TQGTSLRSPVSFSPTDHSLSTSSGSSIFTPEYDDSR 36 1 Q9Y2U5 Q9Y2U5 MAP3K2 Mitogen-activated protein kinase kinase kinase 2 1 T(0.12)QGT(0.12)S(0.12)LRS(0.367)PVS(0.113)FS(0.113)PT(0.034)DHS(0.011)LS(0.001)TSSGSSIFTPEYDDSR 60.645 0.00010849 2825900.0 4475.1 3478.1 5462.7 6972.3 7069.1 6501.6 3564.9 4652.1 3983.4 6026.7 True False 4226.391857244684 3744.8590861458165 5111.235829338051 6022.660712111633 6181.016459444172 7397.1363843514655 3730.674913715338 4665.636840803387 4780.1913054953675 5852.693511752887 0.722127657762635 0.6398522455730349 0.8733134272406538 1.0290408510231113 1.0560977517500232 1.2638858278666323 0.6374287165770273 0.7971777150869505 0.8167506629035314 1.0 12.514885015636429 -5.385714726951566 4.310991615419871 0.940466301950218 0.6826082846235644 0.2885986801555438 0.16162610986599724 0.3068345917178691 9.210818972096746 0.047110013329893265 0.1039445840243226 4.114198798780761e-06 5.385714726951566 -0.2578580173266536 TQKPNPAVPPPLS(ph)SSPLYSR ddPTM_A459_Selumetinib_30min_R2 2 TQKPNPAVPPPLSSSPLYSR 20 1 O75140;H0Y770;A0A2R8Y6V4;A0A5F9UWT1;A0A2R8Y5T1;A0A2R8Y5K9;A0A2R8Y721;A0A2R8Y6H3;O75140-6;A0A2R8Y842;A0A2R8Y7U0;O75140-8;O75140-5;O75140-1;O75140-4;O75140-9;A0A2R8YEW8;H7C1T0 O75140 DEPDC5 DEP domain-containing protein 5 1 TQKPNPAVPPPLS(0.653)S(0.134)S(0.134)PLY(0.056)S(0.023)R;TQKPNPAVPPPLS(0.709)S(0.13)S(0.13)PLYS(0.031)R 139.75 4.0499e-05 12402200.0 119760.0 105512.0 139476.0 138979.0 142096.0 101312.0 96419.0 112385.0 94398.0 124412.0 True False 113104.21863726477 113604.43112544702 130502.26600998687 120049.82044785247 124244.63012564223 115266.80838123173 100902.67455062391 112712.0217436618 113280.23770049479 120819.90229880379 0.9361389678791736 0.9402791176282204 1.0801388142761223 0.99362620035028 1.02834572584216 0.9540382518780846 0.8351494466621739 0.9328928396656859 0.9375958393041702 1.0 16.882498599486873 -6.997214114649347 21.960799813024995 0.9170710789714187 0.9966007974767129 0.26386252970216906 0.0539285704414678 22.803480772826344 179746.0202333969 0.01938677005956132 0.016960062085700646 1.0064353565753555e-07 6.997214114649347 0.07952971850529422 TQLAS(ph)WSDPTEETGPVAGILDTETLEK ddPTM_A459_Selumetinib_30min_R1 2 TQLASWSDPTEETGPVAGILDTETLEK 27 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 1 T(0.018)QLAS(0.575)WS(0.406)DPTEETGPVAGILDTETLEK;T(0.026)QLAS(0.609)WS(0.365)DPTEETGPVAGILDTETLEK 179.2 2.6191000000000004e-26 15513100.0 2348.9 2827.1 2803.8 3373.8999999999996 2929.2 3068.2 4070.8 4310.6 2368.1 2752.7 True False 2403.624799836224 2496.101817716867 2423.0593601709725 2784.7117009468116 2664.2543771922633 3037.336693702705 3763.7362785801183 4196.268885197866 4018.4927408191934 3106.0358585686067 0.7738561012440843 0.8036294271461427 0.780113131497336 0.8965484713464078 0.8577667800719032 0.9778820438674648 1.2117491394045297 1.3510046491001186 1.2937689465926145 1.0 11.60085877011186 -7.081332967101941 2.0268333848170164 1.2518051509250658 0.8184196667765866 0.796773338385383 0.09277513810595316 0.1330572985469982 1.0823167342783617 0.041747730793996275 0.03057853179565969 8.292147771411917e-08 7.081332967101941 -0.4333854841484792 TQLEELEDELQATEDAK ddPTM_A459_Selumetinib_30min_R1 2 TQLEELEDELQATEDAK 17 0 P35579;P35579-2;P35749-4;P35749-3;P35749;P35749-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35579-2;P35749-4;P35580 MYH9;MYH11;MYH10 Myosin-9;Myosin-11;Myosin-10 0 ; 293.59 6.5753e-75 10126800.0 1203.27 981.64 826.9000000000001 831.5899999999999 911.9300000000001 911.46 917.24 829.1500000000001 798.83 1181.23 False True 1231.303849844154 866.7091324479454 714.6115218365707 686.3684173776218 829.4460925143179 902.2915399394651 848.0518483258396 807.158248541226 1355.5561657652104 1332.8523766545566 0.9238111222299891 0.6502664118162695 0.5361520408060771 0.5149620688679704 0.6223090471551078 0.6769628473066207 0.636268399396518 0.6055871322878108 1.0170339862900946 1.0 10.380301284697175 -8.263669457430257 24.99999636897351 1.0085170540384185 0.6378625960203985 0.6555853990884648 0.10503812023190776 123.14664961753279 1380470.7828859363 0.08954778265864363 0.02747680481810928 5.4491723286378e-09 8.263669457430257 -0.37065445801802 TQLEELEDELQATEDAK ddPTM_A459_Selumetinib_30min_R2 3 TQLEELEDELQATEDAK 17 0 P35579;P35579-2;P35749-4;P35749-3;P35749;P35749-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35579-2;P35749-4;P35580 MYH9;MYH11;MYH10 Myosin-9;Myosin-11;Myosin-10 0 ;; 207.85 6.9792e-08 5152200.0 30898.9 27305.5 32046.0 34175.0 34755.0 23000.1 26347.1 29699.1 21580.0 29582.7 False True 29181.662836097003 29399.744048979213 29984.19524904666 29520.306044836703 30388.76618635783 26168.15500088011 27572.29235578822 29785.519464049336 25896.60299557918 28728.570585914724 1.0157714860482625 1.0233625777188358 1.0437064788648953 1.0275591664595438 1.057789008174917 0.9108756358978071 0.9597516268110668 1.0367908620783528 0.9014233032629885 1.0 14.81019859170583 -6.7462245234598806 24.999995588767995 0.96394166342511 1.0332885804110088 0.47064972309409336 0.03807404692642806 221.95553044988046 364701.27461689326 0.012273277769942434 0.012229286260514408 1.793806017396454e-07 6.7462245234598806 0.06934691698589879 TQLS(ph)PSIK ddPTM_A459_Selumetinib_30min_R1 1 TQLSPSIK 8 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.011)QLS(0.963)PS(0.026)IK 84.31 0.036854000000000005 10975000.0 2395.0 3075.4 2060.3 2184.0 2022.5 2108.8 2029.0 2426.9 1463.9 2580.0 True False 2450.7988401412413 2715.3307382853277 1780.5225764178106 1802.6053987574726 1839.5652321013756 2087.587386637203 1875.9508964427287 2362.5307283177976 2484.1313809742883 2911.1681313281524 0.8418609745577016 0.9327289307218822 0.6116179128429414 0.6192034665943791 0.6318993438768228 0.717096125150556 0.6443979913955948 0.8115404613336257 0.8533108597341512 1.0 11.507382447801485 -8.416434916875424 1.562316732621527 0.9941323953022618 0.7130779880152356 0.4405162834288625 0.09994786202352486 0.38145432904375504 1.980019185507882 0.1047004150728053 0.030979468307320124 3.83323180690247e-09 8.416434916875424 -0.28105440728702624 TQLS(ph)PSIK ddPTM_A459_Selumetinib_30min_R2 1 TQLSPSIK 8 0 H0Y9Y2;Q8NFC6 H0Y9Y2;Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.307)QLS(0.689)PS(0.004)IK 123.96 0.005656899999999999 29102000.0 104030.0 77017.0 100100.0 99528.0 93700.0 88198.0 96261.0 102480.0 74777.0 81638.0 True False 98248.42906508548 82923.9562513132 93659.67498063942 85972.11470462341 81928.56831137183 100346.47391827093 100737.32723755277 102778.19983352278 89734.48944394928 79280.89881900244 1.239244641882602 1.0459512629975074 1.181364948882121 1.084398839888243 1.0333960579636463 1.2657080761327013 1.2706380570625866 1.2963803559816403 1.131855097263873 1.0 16.27468569820865 -6.772738148294632 24.986378903326806 1.216297694967522 1.114710119786605 0.10672247947864344 0.0989611100990459 351.9753532230934 778362.5762401978 0.03326027636770955 0.02959094196858678 1.6875702152618987e-07 6.772738148294632 -0.10158757518091699 TQLWASEPGT(ph)PPLPTSLPSQNPILK ddPTM_A459_Selumetinib_30min_R1 2 TQLWASEPGTPPLPTSLPSQNPILK 25 0 Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;H7C3A1 Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 1 TQLWAS(0.024)EPGT(0.976)PPLPTSLPSQNPILK;TQLWAS(0.154)EPGT(0.845)PPLPTSLPSQNPILK 179.17 2.3065e-20 374640000.0 11666.599999999999 11605.2 13239.1 13407.3 11960.2 10357.7 11782.7 11500.8 6987.6 9353.5 True False 11938.409080748133 10246.457788888893 11441.302937170816 11065.966741190965 10878.402021744814 10253.510942039153 10893.921452693809 11195.76142413669 11857.446845888346 10554.112835805388 1.1311617818076045 0.9708497481784769 1.0840610779103657 1.0484980512667141 1.0307263330404481 0.9715180329751234 1.032196795900798 1.0607960705284933 1.1234906268636173 1.0 13.36551769237226 -10.803476569731005 4.045543576428472 0.999945892295667 1.0458394607385584 0.073222026858628 0.051539230619982085 2.569145497562078e-05 4.568613762938176e-06 0.048949682447039025 0.011857469463614228 1.5722566137149273e-11 10.803476569731005 0.045893568442891386 TQLWASEPGT(ph)PPLPTSLPSQNPILK ddPTM_A459_Selumetinib_30min_R2 2 TQLWASEPGTPPLPTSLPSQNPILK 25 0 Q9BXP5-5;Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;H7C3A1 Q9BXP5-5 SRRT Serrate RNA effector molecule homolog 1 T(0.017)QLWAS(0.178)EPGT(0.8)PPLPT(0.002)S(0.003)LPSQNPILK;T(0.004)QLWAS(0.059)EPGT(0.93)PPLPT(0.006)S(0.001)LPSQNPILK 111.8 2.0943e-07 115790000.0 451040.0 409200.0 407640.0 545550.0 495970.0 386640.0 409890.0 398220.0 405550.0 423840.0 True False 425973.0024561782 440584.3242146195 381412.8862048733 471245.1488737586 433661.8145719438 439896.15043153206 428950.69718162616 399378.75427113025 486671.3320137688 411602.6379314299 1.034913198314201 1.0704118088961756 0.9266531626758282 1.1449031309470488 1.0535933801381243 1.068739871644884 1.0421475900576864 0.970301736350057 1.182381469806918 1.0 18.65089270282612 -5.767792081385143 24.99999846368025 1.0633743194286391 1.016634634568301 0.12151386220258042 0.06736932753570742 365.2984280377989 1437580.0221734105 0.01821467212210693 0.027755041277126018 1.7068993720138432e-06 5.767792081385143 -0.04673968486033808 TQMAEVLPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 4 TQMAEVLPSPR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 TQMAEVLPS(1)PR;TQMAEVLPS(1)PR;TQMAEVLPS(1)PR;TQMAEVLPS(1)PR 149.82 0.00062438 477100000.0 15896.5 20411.199999999997 22537.300000000003 23292.3 19674.899999999998 17771.100000000002 18932.0 17960.199999999997 8941.800000000001 14497.7 True False 16266.857520795505 18021.447215090553 19476.85844852746 19224.7370556221 17895.30876888572 17592.338868867784 17503.943997759354 17483.837153048462 15173.58151676748 16358.621014556658 0.9943905116647975 1.1016483112515556 1.190617377295803 1.1752052351182314 1.093937487332315 1.0754169836939989 1.0700134187462094 1.0687842904050735 0.9275587167931407 1.0 13.99776351784678 -7.910487293655909 1.4001145663830903 0.9672401136109918 1.1119562632836129 0.4614304468842044 0.055951670858867396 0.4012607097516473 1.4199416031479493 0.05168199494818602 0.018234253281702077 1.2288891402009783e-08 7.910487293655909 0.14471614967262103 TQMAEVLPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 TQMAEVLPSPR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 TQMAEVLPS(1)PR;TQMAEVLPS(1)PR;TQMAEVLPS(1)PR;TQMAEVLPS(1)PR;TQMAEVLPS(1)PR 193.51 2.0322e-05 408099000.0 1050325.0 918817.0 1140243.0 1152898.0 1258876.0 1006385.0 958856.0 951963.0 833968.0 1099805.0 True False 991952.1412841097 989287.3094376926 1066881.00678271 995871.3035400172 1100724.7423857693 1145005.398696559 1003444.7039371195 954733.0547240423 1000784.9030128436 1068050.7720134403 0.9287499876191532 0.9262549453269283 0.9989047662701231 0.9324194407562164 1.0305921508869222 1.0720514686189004 0.9395103025350299 0.8939023122695032 0.9370199706201324 1.0 20.02654879948725 -1.5555738425735717 22.621000709047287 0.9658847617047985 0.0011791421321142304 0.0 0.05337816861177926 0.0 0.0 0.01322466578391235 0.0 0.027824422382901455 1.5555738425735717 -0.9647056195726843 TQPDGTSVPGEPAS(ph)PISQR ddPTM_A459_Selumetinib_30min_R1 6 TQPDGTSVPGEPASPISQR 19 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 TQPDGTSVPGEPAS(1)PISQR;TQPDGTSVPGEPAS(0.992)PIS(0.008)QR;TQPDGTSVPGEPAS(1)PISQR;TQPDGTSVPGEPAS(1)PISQR;TQPDGTSVPGEPAS(0.998)PIS(0.001)QR;TQPDGTSVPGEPAS(0.996)PIS(0.004)QR 319.76 4.9816999999999976e-135 1082334400.0 10900.5 14132.399999999998 14540.400000000001 14851.5 13609.000000000002 12089.2 13140.4 12671.0 6783.200000000001 10733.35 True False 11154.46044131925 12477.772038025478 12565.89354470005 12257.964322182517 12378.068352864095 11967.593624115367 12149.209048603267 12334.923918791383 11510.594974673682 12111.080024182571 0.9210128592203826 1.0302773999602612 1.0375535063437231 1.0121280924332643 1.0220449644580352 0.9881524686666506 1.0031482761524622 1.0184825708493261 0.9504185383706588 1.0 13.564039904867006 -9.524200118320781 14.263526466361323 0.9999999999999964 1.0018071561377735 0.0 0.03498467371150083 0.0 0.0 0.03289574126814795 0.007978389169503757 2.9908861502157223e-10 9.524200118320781 0.001807156137777044 TQPDGTSVPGEPAS(ph)PISQR ddPTM_A459_Selumetinib_30min_R2 6 TQPDGTSVPGEPASPISQR 19 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 TQPDGTSVPGEPAS(0.631)PIS(0.369)QR;TQPDGTSVPGEPAS(0.997)PIS(0.003)QR;TQPDGTSVPGEPAS(1)PISQR;TQPDGTSVPGEPAS(0.994)PIS(0.006)QR;TQPDGTSVPGEPAS(0.999)PIS(0.001)QR;TQPDGTSVPGEPAS(1)PISQR 205.92 2.6937000000000003e-16 1573133900.0 174248.0 163702.0 189695.0 185790.0 193816.0 132588.0 150894.0 151995.0 135519.0 161092.0 True False 164563.993730011 176257.41701510648 177490.23022429954 160485.0814943731 169467.10134297583 150850.79348597128 157910.86999078857 152437.28028587322 162626.58671723324 156440.85539271837 1.0519246607089998 1.1266712686570395 1.1345516475139454 1.025851470138682 1.083266266459342 0.9642672504397002 1.0093966157010583 0.9744083788292077 1.0395403829069243 1.0 17.255257804059703 -6.336291962067432 1.438802595285681 0.9981439963578205 1.1016606571145466 0.553695143667517 0.0373343647443828 0.28597107512176007 1.1923929244736688 0.014028042564638176 0.01822962762214326 4.610075499672971e-07 6.336291962067432 0.10351666075672616 TQPDVMS(ph)QNAR ddPTM_A459_Selumetinib_30min_R1 2 TQPDVMSQNAR 11 0 J3KRA9;Q96Q15-4;Q96Q15-3;Q96Q15-2;Q96Q15 J3KRA9 SMG1 Serine/threonine-protein kinase SMG1 1 TQPDVMS(1)QNAR;TQPDVMS(1)QNAR 174.94 0.00010299 15443000.0 2908.1 3531.8 3448.3999999999996 3773.1000000000004 2866.3 2772.9 3266.2 3050.1 1985.87 2581.7 True False 2975.8530718224392 3118.295214110726 2980.126220705321 3114.198914858894 2607.0436710863664 2745.007143591758 3019.827904367293 2969.201439878905 3369.8763477938483 2913.0863428875573 1.0215464704944741 1.0704437998290701 1.0230133507650554 1.0690376282400154 0.8949421212493721 0.9423020194007731 1.036642086404459 1.0192631080532013 1.1568062017871754 1.0 11.508332747763975 -10.479309435916155 5.541657669254365 0.9999999632821753 1.0222833668415705 0.01054309949365173 0.0674024931565248 3.1866123158548625e-08 6.044219690861406e-09 0.06811537720079269 0.016520378258754114 3.316580661373902e-11 10.479309435916155 0.022283403559395176 TQPDVMS(ph)QNAR ddPTM_A459_Selumetinib_30min_R2 2 TQPDVMSQNAR 11 0 J3KRA9;Q96Q15-4;Q96Q15-3;Q96Q15-2;Q96Q15 J3KRA9 SMG1 Serine/threonine-protein kinase SMG1 1 TQPDVMS(1)QNAR;T(0.073)QPDVMS(0.927)QNAR 151.3 0.00059833 18215700.0 73397.0 46377.0 68401.0 67256.0 73243.0 64413.0 53117.0 63727.0 50174.0 69113.0 True False 69317.88857147066 49933.96677444142 64000.15412937781 58095.6167769287 64041.559539272195 73285.30606700368 55587.04574933872 63912.43501942725 60210.20197869271 67117.52811286075 1.0327836933283645 0.7439780364151001 0.9535535042613466 0.8655803991952542 0.9541704133022273 1.0918951893426643 0.8282046033618362 0.9522465563981437 0.8970861065897258 1.0 16.034401962952536 -6.277752032294823 22.62566969365034 0.9521577639657337 0.8918013200628123 0.07515458512957629 0.09297600967504208 605.2348158499631 839458.3338886627 0.02788857412307159 0.03175250331650835 5.275309780944343e-07 6.277752032294823 -0.060356443902921386 TQPSSGVDSAVGTLPAT(ph)SPQSTSVQAK ddPTM_A459_Selumetinib_30min_R1 2 TQPSSGVDSAVGTLPATSPQSTSVQAK 27 0 Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 Q13428 TCOF1 Treacle protein 1 TQPSSGVDS(0.001)AVGT(0.007)LPAT(0.455)S(0.455)PQS(0.028)T(0.042)S(0.013)VQAK;TQPSSGVDSAVGTLPAT(0.499)S(0.499)PQST(0.001)SVQAK 181.92 3.0577e-26 34976000.0 4861.200000000001 6437.0 6667.0 6472.1 6052.0 5117.5 5735.1 5366.6 2860.83 5011.6 True False 4974.456501751396 5683.353047519884 5761.658019209597 5341.869231363662 5504.597668567385 5066.022596318228 5302.496789644499 5224.26033482644 4854.619563243851 5654.887677117901 0.8796737947386963 1.0050337640687659 1.0188810721252226 0.9446463902332055 0.9734229896097399 0.8958661755241447 0.9376838396102318 0.9238486479521134 0.8584820495883096 1.0 12.465282652948916 -6.747620973989137 24.94624883119935 0.9193234139415104 0.9685297473750927 0.14781878126375803 0.04845177865419168 379.52979304052684 685160.3657163782 0.015641044736519397 0.015560957783951033 1.7880473939383747e-07 6.747620973989137 0.04920633343358227 TQPSSGVDSAVGTLPAT(ph)SPQSTSVQAK ddPTM_A459_Selumetinib_30min_R2 1 TQPSSGVDSAVGTLPATSPQSTSVQAK 27 0 Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 Q13428 TCOF1 Treacle protein 1 TQPSSGVDSAVGTLPAT(0.497)S(0.497)PQS(0.002)T(0.003)S(0.001)VQAK 183.37 1.8284e-26 9856100.0 27740.0 26701.0 31433.0 31465.0 31688.0 26106.0 28222.0 29255.0 25197.0 31962.0 True False 26198.321852018387 28748.8808427531 29410.635001662726 27179.412719847453 27707.070145685688 29701.86453332707 29534.3789208321 29340.127206574038 30237.10406300317 31039.174012750893 0.8440405611713803 0.9262128183869538 0.9475327851695035 0.8756487111635816 0.8926484362729377 0.9569154295512355 0.9515194865913434 0.9452612107049342 0.9741594299700684 1.0 14.921802545851438 -1.5228787589520236 0.08557376781008944 1.0651772283228662 0.5533361776710161 0.6176349187884478 0.027867952294644602 127.83798207818495 0.7945799033834342 0.6625091293445681 7.697905450291759 0.0299999990555934 1.5228787589520236 -0.5118410506518501 TQPSSGVDSAVGTLPATS(ph)PQSTSVQAK ddPTM_A459_Selumetinib_30min_R2 3 TQPSSGVDSAVGTLPATSPQSTSVQAK 27 0 Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 Q13428 TCOF1 Treacle protein 1 TQPSSGVDSAVGTLPAT(0.143)S(0.855)PQST(0.001)SVQAK;TQPSSGVDSAVGTLPAT(0.26)S(0.739)PQST(0.001)SVQAK;TQPSSGVDSAVGTLPAT(0.258)S(0.738)PQS(0.001)T(0.002)S(0.001)VQAK 192.03 1.2493e-32 49755100.0 134541.0 124237.0 143329.0 159243.0 152752.0 110162.0 135980.0 138197.0 109120.0 140974.0 True False 127063.74983029588 133765.5784150827 134107.36818481618 137553.82869050305 133561.9281397937 125335.81554893046 142303.3394392583 138599.13039025522 130947.04906754414 136903.71432556002 0.9281249267506031 0.9770777883862614 0.9795743588512575 1.0047486977847588 0.9755902445581608 0.9155033971604244 1.0394410417591582 1.0123840034074127 0.9564901121393186 1.0 17.062802063226727 -4.687672550401171 2.4630424580336316 0.9855975476836146 0.9052468458679228 0.22455844024761507 0.031767189006671075 1.277776556389669 7.625110651083766 0.008464164335682523 0.24143276642730085 2.0527092984197628e-05 4.687672550401171 -0.08035070181569182 TQQS(ph)PISNGSPELGIK ddPTM_A459_Selumetinib_30min_R1 1 TQQSPISNGSPELGIK 16 0 Q15723-2;Q15723-3;Q15723-1;Q15723 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 T(0.005)QQS(0.683)PIS(0.286)NGS(0.026)PELGIK 164.2 2.6313e-05 3204600.0 1366.5 1564.8 1591.4 1598.3 1141.9 1236.0 1465.7 1480.7 822.83 1268.4 True False 1398.3367912538645 1381.5924885442162 1375.2966209344763 1319.1869088068079 1038.6153466188189 1223.5669621982088 1355.1410689581608 1441.4270260085557 1396.2824128745635 1431.2114952622596 0.9770301565371573 0.9653307656609122 0.9609317878504481 0.9217274408245834 0.7256896343111748 0.8549169471099018 0.9468489272508537 1.0071376807551593 0.9755947443803227 1.0 10.483021164707345 -10.431385147923196 7.767762673643253 0.9999999897025926 0.9231826032008784 0.0743924671086732 0.07753863558569254 4.224383171046035e-10 0.0 0.08449229850879926 0.020492392276907835 3.703521345464697e-11 10.431385147923196 -0.07681738650171421 TQQS(ph)PISNGSPELGIK ddPTM_A459_Selumetinib_30min_R2 1 TQQSPISNGSPELGIK 16 0 Q15723-2;Q15723-3;Q15723-1;Q15723 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 T(0.011)QQS(0.886)PIS(0.103)NGSPELGIK 197.1 1.1013e-06 6759900.0 30825.0 23353.0 27247.0 33913.0 28657.0 24935.0 25286.0 29846.0 21447.0 27175.0 True False 29111.869902251896 25144.100008269823 25493.957684290534 29293.990896811927 25056.85146316951 28369.56991260672 26461.849103258442 29932.8469187287 25736.999279248666 26390.387140870585 1.1031240181075848 0.9527749583229627 0.9660319702096466 1.1100250534576113 0.94946888537168 1.074996352314627 1.0027078785167642 1.134232959863326 0.9752414446163988 1.0 14.687724894371167 TQQSPIS(ph)NGSPELGIK ddPTM_A459_Selumetinib_30min_R2 1 TQQSPISNGSPELGIK 16 0 Q15723-2;Q15723-3;Q15723-1;Q15723 Q15723-2 ELF2 ETS-related transcription factor Elf-2 1 TQQS(0.07)PIS(0.468)NGS(0.462)PELGIK 161.2 4.8475e-05 5718100.0 34079.0 29830.0 32505.0 34486.0 39412.0 24835.0 25741.0 29258.0 27277.0 37656.0 True False 32185.02560904595 32117.865081432326 30413.663688768072 29788.947308331775 34460.712212249564 28255.795820316336 26938.007504823843 29343.135936077364 32733.162183058972 36568.77343796221 0.8801231920902911 0.8782866380771367 0.8316839978339418 0.8146006690344099 0.9423535156493857 0.7726755142130052 0.7366396237085538 0.8024096292389211 0.8951123897712829 1.0 15.158324617258387 -6.788810224050198 24.999980579372615 0.8224725891956124 0.8647620918757382 0.0012737389866092075 0.07555908234603576 664.0954951968937 606566.4629128319 0.026223768673503678 0.02313284062306261 1.6262592355815948e-07 6.788810224050198 0.04228950268012577 TQS(ph)ESGDVSR ddPTM_A459_Selumetinib_30min_R2 2 TQSESGDVSR 10 0 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 T(0.013)QS(0.986)ESGDVSR;T(0.018)QS(0.977)ES(0.005)GDVSR 123.28 0.004203899999999999 5426700.0 17516.9 16716.3 21700.0 20451.8 23841.0 20422.9 27248.0 31685.0 20688.0 27689.0 True False 16543.380823706608 17998.386458623772 20303.845625173584 17666.22955867715 20845.880438755757 23235.96909437238 28515.085990887706 31777.19810426586 24826.17807101678 26889.546625338204 0.6152346506325126 0.6693451068328452 0.7550832265071041 0.6569924664341548 0.7752410529343973 0.864126473314242 1.0604524646026476 1.181767716169747 0.9232650299735029 1.0 14.714757810219874 -6.921020318299896 1.8059060801625617 1.058101787290491 0.6821875600071955 0.8383924023004746 0.07214027289411229 0.12836083417110147 0.8541277602134756 0.03185080639584412 0.025844329579077344 1.1994431863496525e-07 6.921020318299896 -0.3759142272832955 TQS(ph)GNFYTDTLGMAEFR ddPTM_A459_Selumetinib_30min_R1 4 TQSGNFYTDTLGMAEFR 17 0 H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 H0YDJ2 PPFIBP2 Liprin-beta-2 1 TQS(1)GNFYTDTLGMAEFR;T(0.069)QS(0.931)GNFYTDTLGMAEFR;T(0.154)QS(0.761)GNFYT(0.084)DTLGMAEFR;T(0.397)QS(0.603)GNFYTDTLGMAEFR 267.69 1.8544e-51 139044000.0 3856.5399999999995 4291.68 4323.99 4270.89 4110.13 3920.9399999999996 4104.13 4038.66 2213.38 3261.68 True False 3946.389878479458 3789.208110452098 3736.8159079769175 3525.059236034478 3738.369467202388 3881.498903528675 3794.55216984598 3931.5416173834733 3755.9442011208935 3680.3483994536487 1.0722870364841826 1.0295786428846274 1.0153429790863417 0.9578058524453219 1.015765101955389 1.054655288641936 1.0310306954660284 1.0682525648841057 1.0205403927732677 1.0 11.845626629849917 -6.725052203780745 20.054503952532727 1.0389199156822573 1.0152812270258595 0.055823947119732265 0.03127386780454911 50.98847662954542 28100.076656702422 0.01073288250166183 0.010731255829487325 1.883422681606732e-07 6.725052203780745 -0.023638688656397733 TQS(ph)GNFYTDTLGMAEFR ddPTM_A459_Selumetinib_30min_R2 3 TQSGNFYTDTLGMAEFR 17 0 H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 H0YDJ2 PPFIBP2 Liprin-beta-2 1 T(0.297)QS(0.655)GNFY(0.005)T(0.028)DT(0.016)LGMAEFR;T(0.16)QS(0.819)GNFY(0.003)T(0.013)DT(0.005)LGMAEFR;T(0.101)QS(0.898)GNFYT(0.001)DTLGMAEFR 186.89 6.212500000000001e-08 42503000.0 44427.1 42689.3 53677.7 66492.0 63354.0 43627.8 48622.7 53402.9 35320.0 43836.6 True False 41958.01963777243 45963.43204226581 50224.13522186082 57435.67489490222 55394.90412805391 49637.13343626318 50883.75189405221 53558.293597673975 42384.98692325564 42570.923456834884 0.9856027595998965 1.0796907445259154 1.1797755637785488 1.3491761566586538 1.301238019518698 1.165986767625399 1.1952700989830813 1.25809564953365 0.99563231148209 1.0 15.377580765232757 -10.648343188008756 12.326231807294617 0.9999999977909216 1.17825403575711 0.15652426654775775 0.11460209118901361 0.0 0.0 0.11710130877943005 0.028401238905785976 2.2472780608431753e-11 10.648343188008756 0.17825403796618844 TQS(ph)LPVTEK ddPTM_A459_Selumetinib_30min_R1 2 TQSLPVTEK 9 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 T(0.062)QS(0.928)LPVT(0.009)EK;T(0.102)QS(0.786)LPVT(0.112)EK 126.71 0.004739 29218000.0 6738.9 6272.799999999999 6658.799999999999 7312.4 6971.5 4593.700000000001 6177.8 7180.4 3096.5 5351.9 True False 6895.903258383213 5538.377659854393 5754.5715341702235 6035.4266107482335 6340.929055918291 4547.491548745883 5711.803572224688 6989.9524667737105 5254.534340588075 6038.8684969206015 1.141919758958096 0.9171217526393523 0.9529221471049834 0.9994300445233866 1.0500193967051474 0.7530370219296519 0.9458400319757428 1.1574937375003438 0.8701190203541471 1.0 12.560062541695126 -4.752403019627266 24.77580353782324 0.9623966198274189 1.141920148854309 0.22240146860447274 0.10162993331490841 511.0325476349807 1401028.9851387367 0.025372192323386833 0.3003141939814262 1.768467082178101e-05 4.752403019627266 0.17952352902689006 TQS(ph)LPVTEK ddPTM_A459_Selumetinib_30min_R2 3 TQSLPVTEK 9 0 Q9NQW6;Q9NQW6-2 Q9NQW6 ANLN Actin-binding protein anillin 1 T(0.015)QS(0.694)LPVT(0.291)EK;T(0.005)QS(0.987)LPVT(0.007)EK;TQS(0.915)LPVT(0.084)EK 130.69 0.003784000000000001 41002000.0 221721.0 136002.0 216141.0 244022.0 242849.0 111021.0 205159.0 252350.0 130043.0 138070.0 True False 209398.63443948724 146432.91608464505 202234.72337652784 210785.78263857047 212340.13752239433 126313.13500170474 214699.30001484597 253084.29672120858 156055.23370500922 134083.56035105823 1.561702522600375 1.0921019377860617 1.5082738170662824 1.5720479235984643 1.5836403580457168 0.9420478891744154 1.601235076490505 1.8875117580304555 1.163865527559267 1.0 17.032772837302552 TQS(ph)LSALPK ddPTM_A459_Selumetinib_30min_R1 3 TQSLSALPK 9 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 T(0.002)QS(0.853)LS(0.145)ALPK;T(0.002)QS(0.928)LS(0.07)ALPK;T(0.309)QS(0.687)LS(0.003)ALPK 108.98 0.011693 64843000.0 10848.4 12179.9 13401.7 13265.0 12248.8 12604.6 17465.8 16977.3 10838.9 10566.9 True False 11101.14661268819 10753.87164571811 11581.822750268684 10948.516764889133 11140.898202701277 12477.809168061114 16148.340644203754 16527.006853957624 18392.8216580656 11923.26454532228 0.9310492584049372 0.9019234291783835 0.9713633968485964 0.9182482468012035 0.9343832102653514 1.0465094622895366 1.3543556450350716 1.3861142467430598 1.5425994775299563 1.0 13.54149167395131 -7.150985677089798 2.9160493606147386 1.357377293120793 0.933007266195051 0.6670684405225925 0.12903249027785516 0.14542336918554705 2.3808144246877894 0.051897873716681676 0.03819950144289096 7.063408488019149e-08 7.150985677089798 -0.424370026925742 TQS(ph)LSALPK ddPTM_A459_Selumetinib_30min_R2 4 TQSLSALPK 9 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 T(0.009)QS(0.973)LS(0.018)ALPK;T(0.019)QS(0.975)LS(0.006)ALPK;T(0.107)QS(0.742)LS(0.151)ALPK;T(0.008)QS(0.905)LS(0.087)ALPK 99.539 0.018718 119556400.0 318415.0 279542.0 339996.0 333583.0 318356.0 213236.0 269445.0 321971.0 268936.0 370183.0 True False 300718.769016238 300981.9725307991 318121.0275196552 288148.4199372278 278361.27314124996 242607.32343631875 281974.72639513836 322907.8823048313 322730.7146996793 359494.85493905743 0.836503679773711 0.837235827983748 0.8849112112427421 0.801536978842369 0.7743122587621971 0.6748561769470838 0.7843637329467191 0.898226714147471 0.8977338903901406 1.0 18.455611597515784 -8.265257709305121 1.573493719523279 0.9864040158970032 0.800142360912825 0.5581055800751653 0.055820099295548674 0.31075756380146957 1.4670608991664202 0.05912421735970228 0.017915457966255745 5.4292806367312375e-09 8.265257709305121 -0.18626165498417824 TQS(ph)PEFEAQSSK ddPTM_A459_Selumetinib_30min_R1 1 TQSPEFEAQSSK 12 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 T(0.376)QS(0.624)PEFEAQSSK 181.75 3.2168e-10 0.0 1894.6 2956.7 1982.7 2193.6 1955.0 2000.9 2072.8 1911.4 894.04 1641.3 True False 1938.7404937501442 2610.5281894674627 1713.4602301915213 1810.5289389717902 1778.170595183284 1980.7727626718424 1916.447027179146 1860.7034628977863 1517.1205819019433 1851.976842615853 1.0468492095245319 1.4095900820121392 0.925206077507599 0.9776196425947102 0.9601473162438035 1.0695451028826417 1.0348115500581698 1.0047120569119035 0.8191898229996565 1.0 10.854850343707243 -5.281053053672306 24.998574107887993 0.9793046481562769 1.228219675548091 0.49102833328485074 0.10345141279044076 557.771664021438 710906.0948662732 0.02574078392523417 0.053698373840725115 5.235364771516261e-06 5.281053053672306 0.24891502739181404 TQS(ph)PEFEAQSSK ddPTM_A459_Selumetinib_30min_R2 1 TQSPEFEAQSSK 12 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 T(0.021)QS(0.979)PEFEAQSSK 146.96 0.00064245 3945900.0 14887.0 13005.0 16078.0 18305.0 18304.0 14217.0 14868.0 15553.0 10213.0 15662.0 True False 14059.640137382761 14002.441682334143 15043.558984402805 15811.827422113704 16004.487880163813 16175.262700923578 15559.391460383093 15598.256655062241 12255.885375062559 15209.797365236978 0.9243805028932878 0.9206198706064074 0.9890703092985235 1.0395817276469905 1.0522485931826517 1.0634765416331737 1.022984796361925 1.0255400700283563 0.8057888662655174 1.0 13.892713312222964 -1.6556264322903176 16.77041683592053 0.9901276595136318 0.004925068662990473 0.0 0.075664917325089 0.0 0.0 0.017915790096496274 0.0 0.02209904812708595 1.6556264322903176 -0.9852025908506413 TQS(ph)PGGCSAEAVLAR ddPTM_A459_Selumetinib_30min_R1 2 TQSPGGCSAEAVLAR 15 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7 Q96MH2 HEXIM2 Protein HEXIM2 1 T(0.196)QS(0.802)PGGCS(0.002)AEAVLAR;T(0.068)QS(0.932)PGGCSAEAVLAR 197.51 2.8099e-05 216060000.0 5492.200000000001 6742.7 8409.0 8412.9 7615.6 6205.0 8283.7 6624.7 3772.5 5760.6 True False 5620.1575740391345 5953.261549403809 7267.103987330664 6943.744944691729 6926.770324643381 6142.583333689225 7658.853839754866 6448.991435941703 6401.6569675015435 6500.029122995722 0.8646357528085853 0.9158822886412054 1.118010988846372 1.0682636667159282 1.0656521984090717 0.9450085864935697 1.178279926879015 0.992148083325741 0.9848658900394525 1.0 12.666230466727392 -5.101627095000934 5.196636598635658 1.0462609820481454 0.8759848579390298 0.4754663417550079 0.06543614226098951 0.16802845818690162 6.70483813446369 0.01647671349693466 0.047223485215485514 7.913578321954208e-06 5.101627095000934 -0.17027612410911563 TQS(ph)PGTDLLPYLDWDYVR ddPTM_A459_Selumetinib_30min_R2 2 TQSPGTDLLPYLDWDYVR 18 0 C9JXU1;A6NN40;Q2M3G4-2;Q2M3G4 C9JXU1 SHROOM1 Protein Shroom1 1 T(0.209)QS(0.79)PGT(0.001)DLLPYLDWDYVR;T(0.136)QS(0.686)PGT(0.178)DLLPYLDWDYVR 139.81 0.00019593 0.0 2332.6000000000004 2166.15 2571.69 3297.8999999999996 2868.73 1439.6 403.85 1707.28 995.75 2395.2 True False 2202.9634301376404 2332.286739729957 2406.230265244362 2848.7203308051794 2508.3344906284074 1637.8918326123376 422.62982521359356 1712.24790214458 1194.9278235796082 2326.044352523026 0.9470857371004634 1.0026836922521103 1.0344730798595303 1.2247059380940928 1.0783691583127613 0.7041533111076494 0.18169465459898612 0.736120057335678 0.5137166977420218 1.0 11.183662890740187 -6.849499073796705 4.4430620433537635 0.5693136442295494 1.0626910072779359 0.5264846346023979 0.20357217273228465 0.15514956444677758 5.536595438125387 0.07109396797586709 0.06308810609399275 1.4141677410085982e-07 6.849499073796705 0.4933773630483864 TQS(ph)SLTVSEVLTR ddPTM_A459_Selumetinib_30min_R1 1 TQSSLTVSEVLTR 13 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 T(0.001)QS(0.899)S(0.083)LT(0.017)VSEVLTR 201.16 0.00010021 85392000.0 1359.5 1584.2 1113.0 1109.6 1159.3 1106.3 915.35 1006.3 692.2 1055.9 True False 1391.173704873493 1398.7211275254012 961.8607132713796 915.8291897716541 1054.441519691039 1095.1716264400309 846.3044125474867 979.6096550769287 1174.612843712278 1191.4350503369753 1.167645441083864 1.173980173849845 0.8073127553191717 0.768677394132923 0.885018045585288 0.9192038006018723 0.7103235818923785 0.8222098676716487 0.9858807187014185 1.0 10.218484591531649 -5.2570904299194865 24.762255814767006 0.850046824473957 1.1708128551007144 0.6661363414889685 0.08700989216551033 172.3959847118919 981585.5051530334 0.022180262154585483 0.05458254080380257 5.532349012206931e-06 5.2570904299194865 0.32076603062675746 TQS(ph)SLTVSEVLTR ddPTM_A459_Selumetinib_30min_R2 2 TQSSLTVSEVLTR 13 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 T(0.232)QS(0.379)S(0.379)LT(0.01)VSEVLTR;TQS(0.5)S(0.5)LTVSEVLTR 196.45 0.00018872 97057000.0 71092.0 59984.0 59598.0 60491.0 72092.0 59613.0 67272.0 63728.0 59214.0 61809.0 True False 67140.9912438245 64584.57992104048 55763.52956539611 52252.021447204585 63035.15844934279 67824.14963706533 70400.28129693915 63913.437929261636 71058.4545773969 60024.41357093174 1.11856138610139 1.0759718600952248 0.9290141502090564 0.8705128186793127 1.050158672101864 1.1299427283353052 1.1728607929462918 1.0647907097623566 1.1838258860026356 1.0 15.873261783170632 -6.557265133853912 5.646464416379236 1.116430908112579 0.9944901461448572 0.29442478395231475 0.08119121844380202 0.2280483253729773 19.567746044639907 0.02831289816132852 0.028751915069848893 2.771627528126903e-07 6.557265133853912 -0.12194076196772174 TQS(ph)SSSLTR ddPTM_A459_Selumetinib_30min_R2 1 TQSSSSLTR 9 0 Q9UF83 Q9UF83 Uncharacterized protein DKFZp434B061 1 T(0.003)QS(0.959)S(0.015)S(0.015)S(0.007)LTR 104.07 0.014676 8911000.0 20747.0 19098.0 19067.0 22596.0 20311.0 18314.0 14441.0 27333.0 16727.0 31498.0 True False 19593.964796821412 20562.75519025125 17840.249978579934 19518.385819725838 17759.350597356177 20836.58726206053 15112.53511429863 27412.534504778247 20072.867391429703 30588.570898367667 0.6405648979785136 0.6722365441187893 0.5832325425681121 0.6380940739133197 0.5805877841224641 0.6811886482468018 0.494058227319966 0.8961691801770671 0.656221157180667 1.0 14.90070508513795 -8.844164241151944 0.6824923814499251 1.0011289606035396 0.6184199704720671 0.5782373478270383 0.09337141078097072 0.8123067606197323 0.7370179395169232 0.09307104370308718 0.03376882061941451 1.4316463779617801e-09 8.844164241151944 -0.3827089901314725 TQS(ph)VEITK ddPTM_A459_Selumetinib_30min_R2 2 TQSVEITK 8 0 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 1 T(0.021)QS(0.979)VEITK;T(0.16)QS(0.838)VEIT(0.002)K 106.49 0.013705000000000002 14357700.0 90350.0 89786.0 61219.0 70074.0 59913.0 40779.0 47867.0 44058.0 50089.0 51430.0 True False 85328.70869970656 96672.29749250674 57280.23619020742 60529.80031560758 52386.193310984185 46395.937095094814 50092.91034666109 44186.20148580545 60108.199603594265 49945.0822688123 1.708450658674542 1.9355718941897264 1.1468643876070954 1.211927132081326 1.0488759039184967 0.928939046398694 1.0029598124806993 0.8846957393720638 1.2034858463158087 1.0 15.608055012808952 -5.335986187238576 4.356550427447747 1.0397428896193115 1.8239160044791969 0.8813842785153795 0.11300542930115881 0.06380110175103244 2.2786552599921928 0.03112619238210564 0.07040963951788615 4.613322470261757e-06 5.335986187238576 0.7841731148598854 TQSAS(ph)PPPK ddPTM_A459_Selumetinib_30min_R2 3 TQSASPPPK 9 0 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 TQS(0.004)AS(0.996)PPPK;TQS(0.06)AS(0.94)PPPK;TQS(0.02)AS(0.98)PPPK 103.88 0.014845 78434200.0 204459.0 145566.0 154772.0 174697.0 179865.0 162543.0 243451.0 284191.0 217310.0 225813.0 True False 193095.98729422622 156730.44413153816 144814.13802301206 150902.967230866 157268.75068649827 184931.82283155527 254771.95388900474 285017.948759647 260778.07214871704 219293.19195736604 0.8805379937730444 0.7147072954367364 0.6603676873432812 0.6881333883826355 0.7171620298959109 0.8433085458827598 1.161786882734309 1.2997117977791983 1.1891754131583634 1.0 17.742501498113583 -7.179970336720355 2.9427168386290807 1.1944249954385604 0.7271358089536658 0.8390398660099102 0.08909784835729476 0.09538122140883082 1.6100256580236127 0.03810251116137042 0.027575040631019454 6.607385763816485e-08 7.179970336720355 -0.4672891864848946 TQSAS(ph)PPPKER ddPTM_A459_Selumetinib_30min_R1 4 TQSASPPPKER 11 1 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 T(0.048)QS(0.03)AS(0.922)PPPKER;TQSAS(0.999)PPPKER;T(0.006)QS(0.089)AS(0.905)PPPKER;TQSAS(0.999)PPPKER 146.67 0.003228 106014700.0 10398.8 10897.5 13475.899999999998 15244.3 12509.800000000001 10759.400000000001 11641.3 10450.4 6516.5 8200.0 True False 10641.071807457502 9621.615633889693 11645.946797820103 12582.169175951714 11378.290798784574 10651.17020475357 10763.187368535595 10173.221444316749 11058.024553670986 9252.549874763903 1.1500691108383816 1.0398880053737842 1.2586743065913246 1.359859643693385 1.2297464972135492 1.1511605286024307 1.1632671549160645 1.0995046319138417 1.1951326610874555 1.0 13.175635291883678 -9.14453192210255 0.5562145551421828 0.9933347573194361 1.19927338217931 0.31259349525568825 0.0826731985350028 3.0726599954734435 1.5317325214725228 0.1529327974454976 0.04225546914637757 7.169156779343672e-10 9.14453192210255 0.2059386248598739 TQSAS(ph)PPPKER ddPTM_A459_Selumetinib_30min_R2 3 TQSASPPPKER 11 1 Q9UN81 Q9UN81 L1RE1 LINE-1 retrotransposable element ORF1 protein 1 T(0.002)QS(0.005)AS(0.992)PPPKER;T(0.008)QS(0.179)AS(0.813)PPPKER;T(0.002)QS(0.045)AS(0.953)PPPKER 77.192 0.027468 95736000.0 444480.0 366800.0 404860.0 443700.0 417350.0 288660.0 301920.0 325121.0 235768.0 403830.0 True False 419777.5809944175 394932.38055210834 378811.74837823905 383267.29457480775 364918.7618436608 328420.294805416 315959.87824313034 326067.0482833214 282928.18790832814 392170.3786236537 1.0703959398148655 1.007042862181861 0.9659366668836703 0.9772979181138262 0.9305107721913262 0.8374428888740333 0.805669921711097 0.8314423170553419 0.7214420143134781 1.0 18.581121044575156 -6.403817077308559 1.1686226445067218 0.8209667057481425 1.021791729737887 0.5612463133254575 0.06914704632984184 0.3227496541526082 0.918878576081747 0.02909210543233517 0.037157781732046404 3.9462348053759005e-07 6.403817077308559 0.20082502398974444 TQSEESRPQSLQQPATSTTETPAS(ph)PAHTTPQTQSTSGR ddPTM_A459_Selumetinib_30min_R1 1 TQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGR 38 1 B8ZZU6;E9PBF9;P15336-5;P15336;P15336-4;F5H629;P15336-2 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 TQSEESRPQSLQQPAT(0.01)S(0.031)T(0.031)T(0.031)ET(0.01)PAS(0.877)PAHT(0.008)T(0.002)PQT(0.001)QSTSGR 81.218 2.5167e-07 6810000.0 275.22 446.91 370.53 501.51 606.5 419.8 769.29 400.62 134.21 261.91 True False 281.6320905151031 394.58556943717747 320.21406117560116 413.9306930086354 551.6421820862716 415.57719314790313 711.2618359410676 389.9942562028414 227.74456768943193 295.5286997194407 0.9529771246666388 1.335185279168406 1.0835294896218048 1.4006446527920953 1.866628123122971 1.40621602417102 2.406743699059692 1.3196493490245833 0.770634350929844 1.0 8.207154431623776 -5.908803976232237 4.927562570600102 1.531077951190874 1.1486194028326628 0.09532410663714153 0.43348589803205445 0.4449097235198407 18.344222998515644 0.12657901732310273 0.19119911389276995 1.2336615347869406e-06 5.908803976232237 -0.38245854835821125 TQSEESRPQSLQQPATSTTETPAS(ph)PAHTTPQTQSTSGR ddPTM_A459_Selumetinib_30min_R2 2 TQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGR 38 1 B8ZZU6;E9PBF9;P15336-5;P15336;P15336-4;F5H629;P15336-2 B8ZZU6 ATF2 Cyclic AMP-dependent transcription factor ATF-2 1 TQSEESRPQSLQQPATSTTET(0.001)PAS(0.994)PAHT(0.002)T(0.002)PQTQSTSGR;TQSEESRPQSLQQPATS(0.001)T(0.001)T(0.001)ET(0.004)PAS(0.957)PAHT(0.025)T(0.01)PQT(0.002)QSTSGR 109.97 4.549e-19 29396000.0 19640.1 19512.8 26168.0 34762.0 32365.0 21471.0 21225.6 20142.5 19869.4 38324.0 True False 18548.581867549616 21009.369016459033 24484.379369564165 30027.355632205214 28299.019353228923 24428.435355667894 22212.63245772848 20201.111340229625 23843.835197421726 37217.48654228974 0.49838351782496393 0.5645026294988074 0.6578729958494883 0.806807724591652 0.7603689013516031 0.6563698310983517 0.5968332233421663 0.542785481154816 0.6406621567614 1.0 15.183693006805294 -11.822571877445645 2.0508529569602922 2.4824229253410395 0.6399793947407078 0.5982159960256321 0.0894253918047128 3652876.647421471 474969.7258092785 25087642.55191896 0.0264874909403601 1.5046244769229524e-12 11.822571877445645 -1.8424435306003317 TQSGNFYTDT(ph)LGMAEFR ddPTM_A459_Selumetinib_30min_R2 1 TQSGNFYTDTLGMAEFR 17 0 H0YDJ2;E9PP16;Q8ND30-3;Q8ND30-2;Q8ND30 H0YDJ2 PPFIBP2 Liprin-beta-2 1 T(0.005)QS(0.02)GNFY(0.002)T(0.168)DT(0.805)LGMAEFR 97.073 0.013418 13414000.0 12696.0 9694.2 10910.0 12360.0 11461.0 9449.3 9915.3 9971.1 8670.6 11235.0 True False 11990.40714611484 10437.713968234033 10208.062477909856 10676.546677810727 10021.166717360002 10750.855302795046 10376.381096794212 10000.114250195536 10404.962276805783 10910.616357964345 1.098966983415404 0.956656675093785 0.9356082317437868 0.9785466125401104 0.9184785156564433 0.9853572841416351 0.9510352812671155 0.9165489759793289 0.9536548564656062 1.0 13.413444983636403 -4.761790312788506 6.420937241964587 0.9520104373694966 1.1032589109683317 0.7326558495908175 0.026026773222112585 0.05752918577122862 10.831574737734943 0.006084966290171212 0.038143873014333064 1.7306517553870027e-05 4.761790312788506 0.1512484735988351 TQSPEFEAQS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 TQSPEFEAQSSK 12 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 TQS(0.002)PEFEAQS(0.772)S(0.226)K 148.89 0.00059074 14633000.0 3324.6 5229.1 3762.3 4084.1 3721.0 3699.8 4066.8 3595.4 1935.9 3297.4 True False 3402.056711454515 4616.874541057363 3251.400324834599 3370.8886030519216 3384.4362069959093 3662.5833711496202 3760.0380018005367 3500.0383124948726 3285.080907458245 3720.6534093959144 0.9143707669365724 1.2408773494994685 0.8738788505867566 0.9059937145823048 0.9096349040330006 0.9843925160834257 1.0105853967222969 0.9407052814046281 0.8829311806260425 1.0 11.861340289789991 -5.2922011365756925 24.999914465761396 0.9384170480601128 1.077624255804022 0.29626223723394585 0.08575929231805197 684.182444536686 556030.151463496 0.021289154363818657 0.0443229290284586 5.102686224529441e-06 5.2922011365756925 0.13920720774390927 TQSPGGCS(ph)AEAVLAR ddPTM_A459_Selumetinib_30min_R2 1 TQSPGGCSAEAVLAR 15 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7 Q96MH2 HEXIM2 Protein HEXIM2 1 TQS(0.135)PGGCS(0.865)AEAVLAR 92.269 0.013678 175840000.0 57732.0 70462.0 67675.0 68971.0 63201.0 41934.0 53889.0 51878.0 37520.0 64717.0 True False 54523.48655950706 75866.20882896018 63320.86417896872 59577.03081838869 55261.125355891265 47710.02786104872 56394.94527902769 52028.956391134765 45025.0483963916 62848.452055040354 0.8675390527002543 1.207129314219535 1.0075166867039882 0.9479474652170163 0.8792758381303586 0.7591281296676335 0.8973163766967416 0.8278478576619472 0.7164066404843245 1.0 15.939589591338933 -6.057291869628058 1.9596444794536951 0.8332699077156361 1.0469720359067851 0.3743455856818866 0.10529961894635699 0.3083981795164611 2.358794094262392 0.03300887577468515 0.05037434658901791 8.764116266672627e-07 6.057291869628058 0.21370212819114898 TQSPHS(ph)PKEESER ddPTM_A459_Selumetinib_30min_R1 1 TQSPHSPKEESER 13 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3;A0A1B0GTZ9 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 TQS(0.001)PHS(0.996)PKEES(0.003)ER 80.585 0.020223 5502500.0 633.92 846.74 1067.3 1081.6 870.35 800.67 884.5 763.85 292.1 590.27 True False 648.6891026064025 747.6032871612534 922.3665222592476 892.7188641465577 791.6269961727729 792.6159867501941 817.7814528849642 743.5902166655194 495.67236586009267 666.0369042166934 0.9739536931054996 1.122465260450527 1.3848579807210772 1.3403444441212433 1.1885632630278684 1.1900481515845833 1.2278320431008747 1.1164399629477502 0.7442115635364658 1.0 9.37945830709433 -8.08248253481858 4.813636920168814 0.8769775665666004 1.20999043491932 0.53946872116195 0.12065688811589649 0.1739062984038449 6.941067525637743 0.08964823935469182 0.032611432684106205 8.27022766674653e-09 8.08248253481858 0.3330128683527196 TQSPHS(ph)PKEESER ddPTM_A459_Selumetinib_30min_R2 1 TQSPHSPKEESER 13 1 Q5T5U3;E7ESW5;A0A1B0GV73;Q5T5U3-3;A0A1B0GTZ9 Q5T5U3 ARHGAP21 Rho GTPase-activating protein 21 1 T(0.001)QS(0.015)PHS(0.982)PKEES(0.002)ER 62.438 0.047204 3965400.0 18965.0 15246.0 18742.0 26594.0 18606.0 11977.0 11372.0 14330.0 12806.0 17276.0 True False 17911.0012229102 16415.319176383407 17536.160124746697 22971.85132279116 16268.547940249553 13626.72303361903 11900.820533190503 14371.697927540794 15367.557829535997 16777.196991561363 1.0675800750220148 0.9784303769360297 1.0452377792051366 1.3692305892543075 0.9696821196313274 0.8122169061061293 0.7093449840981427 0.8566209203342792 0.9159788632907876 1.0 14.034214080776154 -6.518793820035654 12.084174307371278 0.8460727962863415 1.1090040319220233 0.5104282694907954 0.11793307259657394 0.20746908573064102 585.253591746961 0.0397795013862554 0.041538584135558214 3.0283507870691984e-07 6.518793820035654 0.2629312356356819 TQSRPGGPPNPPGPS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 TQSRPGGPPNPPGPSPK 17 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-4;O95785-3;O95785;O95785-2 B9EGQ5 WIZ Protein Wiz 1 TQSRPGGPPNPPGPS(1)PK 62.237 0.029296 5240000.0 12437.0 14942.0 14271.0 12943.0 10060.0 10660.0 12612.0 10110.0 8410.3 14449.0 True False 11745.801329255686 16088.00335389747 13352.81939708997 11180.141072079632 8796.17286245892 12128.318238154705 13198.4829902039 10139.418426199398 10092.595003416105 14031.81982698948 0.8370832489356259 1.1465371956211288 0.9516099523603141 0.796770569315265 0.6268732759481372 0.8643439259978604 0.9406109223849426 0.7226018115409913 0.7192648657021322 1.0 13.77641450790243 -5.685631348318397 4.468919831520893 0.7983894588287281 1.0033004320041357 0.2747828757388534 0.12462604809210098 0.23934390833414962 8.930976773786487 0.03414063810325917 0.06011800921420067 2.0623798254212044e-06 5.685631348318397 0.20491097317540752 TQSSLT(ph)VSEVLTR ddPTM_A459_Selumetinib_30min_R1 1 TQSSLTVSEVLTR 13 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 T(0.001)QS(0.096)S(0.096)LT(0.784)VS(0.023)EVLTR 193.98 0.0004462 91817000.0 2866.3 2597.4 2409.5 2369.7 2143.1 2160.7 2292.2 2242.0 1321.6 2307.3 True False 2933.0792131510802 2293.2952005015 2082.303134436107 1955.876379778197 1949.2569833950351 2138.9653197586326 2119.2975085391927 2182.534876957641 2242.6586741550786 2603.464430005213 1.1266062172184956 0.8808628894910263 0.799820082209434 0.7512591135244665 0.7487165796965131 0.8215842302690303 0.8140297536290707 0.8383194530348435 0.8614132185975699 1.0 11.346216980614125 -4.7658329502280345 2.9307248151686776 0.8176250086042215 1.186205094358319 0.6319864325027008 0.06723157002285095 0.2506643951571238 2.9627472145927065 0.01665082929634587 0.2259164418451427 1.7146167016789774e-05 4.7658329502280345 0.3685800857540974 TQSSS(ph)CEDLPSTTQPK ddPTM_A459_Selumetinib_30min_R1 4 TQSSSCEDLPSTTQPK 16 0 Q5JS72;A0A2U3TZM4;A0A2R8Y6F8;A0A2R8YFN5;O14936-5;O14936-3;O14936-4 Q5JS72 CASK Peripheral plasma membrane protein CASK 1 TQS(0.006)S(0.063)S(0.926)CEDLPS(0.004)TTQPK;TQSS(0.102)S(0.897)CEDLPSTTQPK;TQSS(0.005)S(0.995)CEDLPSTTQPK;TQSS(0.017)S(0.983)CEDLPSTTQPK 309.33 6.455499999999996e-102 66855700.0 16181.3 19273.6 19652.3 20816.2 20619.5 16637.3 18330.0 16862.2 8573.1 15157.5 True False 16558.29280667117 17017.037951946455 16983.62560235681 17181.041438468543 18754.469865668398 16469.943867459755 16947.353342432336 16414.959679855107 14547.924545550028 17103.112771552896 0.9681449820182493 0.9949673009377797 0.9930137179826806 1.0045564025658102 1.096553014423325 0.962979317709565 0.9908929192480312 0.9597644533548083 0.8506009835675739 1.0 14.061971299479122 -7.868581148461001 3.0572612390210447 0.9204840401290871 1.0040702851961978 0.28519174284550053 0.048300583692017215 0.2933304880314759 5.359516903975069 0.03084604855504832 0.012995806079453205 1.35337718684352e-08 7.868581148461001 0.08358624506711065 TQSSS(ph)CEDLPSTTQPK ddPTM_A459_Selumetinib_30min_R2 2 TQSSSCEDLPSTTQPK 16 0 Q5JS72;A0A2U3TZM4;A0A2R8Y6F8;A0A2R8YFN5;O14936-5;O14936-3;O14936-4 Q5JS72 CASK Peripheral plasma membrane protein CASK 1 TQSS(0.002)S(0.998)CEDLPSTTQPK;TQS(0.003)S(0.026)S(0.972)CEDLPSTTQPK 319.11 2.1983e-117 84200000.0 231321.0 183024.0 227037.0 225358.0 214672.0 130637.0 202893.0 198276.0 137592.0 179057.0 True False 218465.10487133206 197061.35228508466 212429.68659919567 194663.8516357658 187702.98416797005 148631.06094538613 212327.9265248523 198852.9503336412 165114.24464169246 173887.15916404247 1.256361343307906 1.1332714458758857 1.2216525223624637 1.1194837650554916 1.0794528191175632 0.8547558178529437 1.22106731483574 1.1435746681331793 0.9495482325174237 1.0 17.40779187404881 -6.046966775826101 2.687480437866819 1.0483323400960927 1.1964258566626784 0.34945293048351167 0.09893172680114379 0.35962647971958817 5.162338722858698 0.03140263146094431 0.04561003343692901 8.974974517646522e-07 6.046966775826101 0.14809351656658576 TQSSSCERDS(ph)PSTSR ddPTM_A459_Selumetinib_30min_R2 3 TQSSSCERDSPSTSR 15 1 Q5JS79;A0A2U3TZM1;A0A2R8YE77;A0A2R8YEK3;O14936-6;O14936-2;O14936 Q5JS79 CASK Peripheral plasma membrane protein CASK 1 T(0.001)QSSS(0.003)CERDS(0.922)PS(0.067)T(0.006)SR;TQSSSCERDS(0.835)PS(0.153)T(0.01)SR;TQSS(0.004)S(0.016)CERDS(0.946)PS(0.026)T(0.007)S(0.001)R 107.63 0.0023055 111058600.0 55743.100000000006 43140.15 62458.4 53264.5 50345.2 32366.34 48081.2 45880.9 28541.34 44727.0 True False 52645.12165930956 46448.86078755454 58439.89454356416 46009.783213612456 44020.38588420145 36824.50954261876 50317.071071090344 46014.405823008135 34250.40551167024 43435.61529529785 1.2120266122950187 1.0693726904009782 1.3454372442121385 1.059263991100715 1.01346292863421 0.8477952779594956 1.1584288775238658 1.0593704155029997 0.7885327577108833 1.0 15.406590853985362 -5.972325830353221 10.143921144216897 0.9881788333506066 1.1964365730184292 0.442717816736955 0.1153212348243666 0.39944956119679303 140.92197331195595 0.032388279457013974 0.04787155993308301 1.0657962053421508e-06 5.972325830353221 0.20825773966782257 TQT(ph)PPLGQTPQLGLK ddPTM_A459_Selumetinib_30min_R1 1 TQTPPLGQTPQLGLK 15 0 P78344-2;P78344;H0Y3P2;D3DQV9;E9PKF8 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 T(0.11)QT(0.888)PPLGQT(0.002)PQLGLK 105.28 0.011157 502420000.0 2900.0 3153.0 3374.8 3295.2 3116.2 2315.0 2909.6 2818.9 1627.7 2647.8 True False 2967.5643575822937 2783.845294210069 2916.52069644946 2719.7551785648457 2834.3402602097935 2291.7132018518237 2690.1265294676 2744.133614922345 2762.0880174956287 2987.6709217560788 0.993270154344185 0.9317777516721265 0.9761853874908022 0.9103262205886588 0.9486788653898465 0.7670567682550565 0.900409248514696 0.9184858998157037 0.924495397864013 1.0 11.544805535300648 -5.967897910251063 2.002643938664629 0.8978760942457388 0.9643235289723673 0.1467195287480637 0.05789254514873718 0.56436794115414 4.567425457566268 0.018558825653610604 0.030318146878156677 1.0767182884112178e-06 5.967897910251063 0.06644743472662851 TQT(ph)PPLGQTPQLGLK ddPTM_A459_Selumetinib_30min_R2 1 TQTPPLGQTPQLGLK 15 0 P78344-2;P78344;H0Y3P2;D3DQV9;E9PKF8 P78344-2 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 T(0.031)QT(0.934)PPLGQT(0.035)PQLGLK 96.756 0.023312 546860000.0 81485.0 75961.0 92299.0 98180.0 96354.0 62881.0 73959.0 80003.0 65707.0 74601.0 True False 76956.3899103 81786.9644468885 86360.58282755276 84807.71463005338 84249.14910431068 71542.28697311501 77398.24004697832 80235.7954847904 78850.23600697494 72447.07529332436 1.0622428800433734 1.1289201684919468 1.1920506449417767 1.1706161261401258 1.162906145806466 0.9875110442133649 1.0683418168864325 1.1075091045419156 1.0883839780657176 1.0 16.144639828545095 -6.736478935561011 24.99149911505994 1.0581930191818378 1.1467664068490036 0.4894517595568505 0.04708676153567038 219.26365974252465 219535.96164568633 0.01635790451005284 0.016350993679699128 1.834514143781576e-07 6.736478935561011 0.08857338766716571 TQT(ph)PPVEENVTQK ddPTM_A459_Selumetinib_30min_R1 1 TQTPPVEENVTQK 13 0 Q6P1Q9-2;Q6P1Q9 Q6P1Q9-2 METTL2B Methyltransferase-like protein 2B 1 T(0.002)QT(0.998)PPVEENVTQK 152.11 0.0010466 4895100.0 2275.5 2736.8 2680.6 2592.2 2459.0 2082.2 2157.2 2033.6 996.59 1498.3 True False 2328.514722647762 2416.374183696199 2316.589243481814 2139.520931620475 2236.58388417171 2061.254958486334 1994.4806672283148 1979.6623219362455 1691.1404419462845 1690.6213996778963 1.3773129354043427 1.4292816736831653 1.3702590325209294 1.2655233939592299 1.3229359835370784 1.2192291892667704 1.179732297017127 1.1709672681970182 1.0003070127164408 1.0 10.723337901262981 -7.269711742432869 0.45200091675811965 0.9784119192687514 1.425224421237878 0.917938091131118 0.04077931583854615 0.27279587251437104 0.1256417281016431 0.04131047317042382 0.0418152312845962 5.373883628737606e-08 7.269711742432869 0.4468125019691266 TQT(ph)PPVEENVTQK ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVEENVTQK 13 0 Q6P1Q9-2;Q6P1Q9 Q6P1Q9-2 METTL2B Methyltransferase-like protein 2B 1 T(0.161)QT(0.839)PPVEENVTQK 158.65 0.00085251 15017000.0 64445.0 61019.0 67393.0 70231.0 61437.0 46262.0 51282.0 50839.0 38586.0 59706.0 True False 60863.40489377528 65698.9610929909 63057.00775195043 60665.41664476745 53718.73480625135 52634.170575376455 53666.71461335521 50986.933073150445 46304.27818292019 57982.13264518198 1.0496924158727494 1.1330897656875019 1.0875248093722911 1.0462777734652442 0.926470489365746 0.9077653438080306 0.9255733131060443 0.8793559454799944 0.7985956374919204 1.0 15.823320777799468 -6.220200574464519 1.9670510041683646 0.8949843344906513 1.0960095921499535 0.7442702728322039 0.050194546457852915 0.15960852829416047 1.2137705521625286 0.016855631690834465 0.02267896960840931 6.022813643443624e-07 6.220200574464519 0.20102525765930224 TQT(ph)PPVS(ph)PAPQPTEERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 2 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.236)QT(0.751)PPVS(0.628)PAPQPT(0.356)EERLPS(0.007)S(0.008)PVY(0.012)EDAASFK;T(0.464)QT(0.521)PPVS(0.657)PAPQPT(0.324)EERLPS(0.012)S(0.012)PVY(0.01)EDAASFK 56.1 0.016508000000000002 24014000.0 4566.3 4284.5 5222.8 5609.4 4293.4 4141.2 4209.4 4234.1 2863.77 3715.2 True False 4672.685905526906 3782.8687481899906 4513.572446786848 4629.823591479015 3905.0627280613335 4099.543287908757 3891.8815689926178 4121.797913704886 4859.608528514748 4192.082109112543 1.114645606623413 0.9023842209500086 1.0766898952135182 1.1044210182369594 0.931532977269863 0.977925331900673 0.9283886783926861 0.9832340604076251 1.1592350536148062 1.0 12.033451259469073 -12.286670181716685 0.0019580500340707157 7.312791919633028e-05 1.9995959719768126 0.0 0.08507821272570225 3402319.305832274 766.9839434669552 399290.47616976657 384062.01701805583 5.168087027201619e-13 12.286670181716685 1.9995228440576163 TQT(ph)PPVSPAPQPT(ph)EER ddPTM_A459_Selumetinib_30min_R1 1 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.191)QT(0.809)PPVS(0.088)PAPQPT(0.912)EER 126.04 0.0094777 20146000.0 1818.7 2486.5 1572.6 1508.1 2715.6 1445.3 2143.9 1785.1 802.92 1128.9 True False 1861.0721714258343 2195.379424057512 1359.0495576734686 1244.7386455431065 2469.9744594781214 1430.7615942274042 1982.1838969362086 1737.7533491780043 1362.496597043429 1273.8053114171905 1.461033452086388 1.7234811351312478 1.0669209379896825 0.9771812335734842 1.9390517823560616 1.1232184238858212 1.556112130456499 1.3642220939121708 1.0696270339205634 1.0 10.314929077392543 -8.283460549101946 3.6944293189752835 1.0097297336182003 1.4029632124667315 0.2165888850699912 0.2810605061284282 0.3598214892268918 10.20010838696633 0.25311356531601154 0.07185198835078162 5.206423013054306e-09 8.283460549101946 0.3932334788485312 TQT(ph)PPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R1 3 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 T(0.028)QT(0.972)PPVSPAPQPTEER;TQT(1)PPVSPAPQPTEER;T(0.383)QT(0.617)PPVSPAPQPTEER 245.04 9.0007e-22 242424000.0 6676.200000000001 9035.7 4366.1 4387.700000000001 5454.200000000001 5694.3 5836.8 6072.099999999999 3210.01 6237.200000000001 True False 6831.742470376175 7977.796043417034 3773.2076012705934 3621.4705623297446 4960.868573017224 5637.020512010726 5396.525476765361 5911.048183039475 5447.152520145689 7037.805375472852 0.970720573516452 1.1335630381624509 0.5361341213584045 0.5145738435664581 0.7048885708471181 0.8009628302106875 0.7667909509934101 0.8398993532330136 0.7739845348848836 1.0 12.780909902795909 -10.122775523980813 21.736441464428147 0.9999999999996619 0.7770990046673549 0.12324769209173647 0.17360389479874436 0.0 0.0 0.18399611103862093 0.04462561179500646 7.537450551433536e-11 10.122775523980813 -0.222900995332307 TQT(ph)PPVSPAPQPTEER ddPTM_A459_Selumetinib_30min_R2 3 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 T(0.403)QT(0.596)PPVS(0.001)PAPQPTEER;T(0.021)QT(0.978)PPVSPAPQPTEER;T(0.044)QT(0.956)PPVSPAPQPTEER 211.26 9.1595e-08 930855800.0 1156947.0 885087.0 954922.0 1004171.0 947579.0 842516.0 960261.0 883013.0 712372.0 722786.0 True False 1092648.5173657937 952970.3268967395 893483.3581604599 867401.1775084026 828535.6545562592 958564.9314012328 1004915.0392210735 885582.4216393292 854866.3053367361 701917.2901564398 1.5566627759265907 1.357667548956297 1.2729182920701738 1.2357598105541476 1.180389293974507 1.3656380101245158 1.4316715848345938 1.2616620705296417 1.2179017632493536 1.0 19.42094151620433 -14.315840608794673 0.141043710291053 7.527655684161778e-12 1.4265553811349347 0.5324789921447058 0.09832541646795671 121.7216755031634 1.1031691702248525 34.62878043710132 0.6598090955812185 4.832361228640875e-15 14.315840608794673 1.426555381127407 TQT(ph)PPVSPAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 1 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.118)QT(0.376)PPVS(0.096)PAPQPT(0.378)EERLPS(0.486)S(0.486)PVY(0.061)EDAASFK 64.70100000000001 0.0018564 48690000.0 5075.0 4845.9 5854.6 5497.9 4944.2 4386.0 4957.3 3735.1 2463.3 3752.7 True False 5193.237625769019 4278.539775202206 5059.577477015828 4537.794973364794 4496.997982969408 4341.880822169371 4583.366869854871 3636.0330146853194 4180.040187686297 4234.395599393475 1.226441295780887 1.0104251420946722 1.1948759529554938 1.0716511641035091 1.0620164973753392 1.0253838405630527 1.0824134784457506 0.858689966333362 0.987163360051913 1.0 12.047940344423758 -6.866604905612577 0.7805194939645141 0.9522597838048805 1.133939147565088 0.46083811812430686 0.07304782628239255 0.5744961892325213 0.7529423685845111 0.050193819576373165 0.043659661588270456 1.3595497188092504e-07 6.866604905612577 0.18167936376020744 TQTCTSSSLS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 1 TQTCTSSSLSPTK 13 0 A0A2R8YCF6;A0A2R8YD00;R4GN03;A0A2R8Y500;A0A2U3TZI0;Q9BZR9 A0A2R8YCF6 TRIM8 Probable E3 ubiquitin-protein ligase TRIM8 1 T(0.001)QTCTS(0.003)S(0.002)S(0.004)LS(0.755)PT(0.236)K 132.81 0.0013857 7156400.0 1928.6 2209.1 2391.1 2444.2 1669.7 1781.1 1796.2 1698.3 1230.1 1776.5 True False 1973.5326275976602 1950.4575450172715 2066.4017533721426 2017.366353316398 1518.6759298094778 1763.1837511094086 1660.711187871083 1653.2555671441403 2087.389857050669 2004.5310795753746 0.9845358087517002 0.9730243471358111 1.030865410083776 1.0064031303239969 0.7576215431547129 0.8795991087765567 0.8284786426074651 0.8247592586563207 1.041335740971822 1.0 10.969049070822091 -6.208542490313054 24.961487383882055 0.8764109020328616 0.9991697990147379 0.3073396060349901 0.07969668781368075 361.16941944933996 170431.72524080015 0.0229667978701591 0.02964998877100439 6.186677956436719e-07 6.208542490313054 0.12275889698187625 TQTCTSSSLS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 3 TQTCTSSSLSPTK 13 0 A0A2R8YCF6;A0A2R8YD00;R4GN03;A0A2R8Y500;A0A2U3TZI0;Q9BZR9 A0A2R8YCF6 TRIM8 Probable E3 ubiquitin-protein ligase TRIM8 1 T(0.001)QTCTS(0.001)S(0.001)S(0.003)LS(0.991)PT(0.002)K;TQTCTSSSLS(1)PTK;TQTCT(0.001)S(0.002)S(0.001)S(0.009)LS(0.819)PT(0.169)K 225.31 1.5672e-09 21383200.0 70327.0 67441.0 66632.0 69508.0 75262.0 53148.0 62251.0 64147.0 48624.0 63318.0 True False 66418.50688128681 72613.50784300629 62344.96966343626 60040.89049201198 65806.91470918324 60468.654570492145 65145.794848016354 64333.65714989244 58350.15866807425 61489.84482007886 1.080154081956612 1.180902440971767 1.013906765350596 0.9764358760002312 1.0702078514222348 0.9833925381894401 1.059456159608711 1.0462484876671043 0.9489397613347141 1.0 15.9080605454899 -5.277365215890234 24.717227051945187 1.015410822712362 1.1305282571745345 0.5507827058890306 0.04262764376943272 425.09891317941134 659762.1836110434 0.010613460260201601 0.0222100911423217 5.28001047474867e-06 5.277365215890234 0.1151174344621726 TQTCTSSSLSPT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 TQTCTSSSLSPTK 13 0 A0A2R8YCF6;A0A2R8YD00;R4GN03;A0A2R8Y500;A0A2U3TZI0;Q9BZR9 A0A2R8YCF6 TRIM8 Probable E3 ubiquitin-protein ligase TRIM8 1 TQTCTSSSLS(0.153)PT(0.847)K 136.81 0.0025119 4444900.0 10987.0 11130.0 13980.0 11539.0 9820.9 9642.9 11427.0 10498.0 9867.1 11323.0 True False 10376.386524445783 11983.63521140938 13080.542020273126 9967.368294114725 8587.11074204004 10971.121945469236 11958.378142170932 10528.547441962537 11840.795709809045 10996.075569312889 0.9436445265439525 1.0898101905422064 1.1895645803651465 0.9064477805091654 0.7809250389297409 0.9977306791239876 1.087513273875961 0.9574822740710243 1.0768201468943652 1.0 13.42470110630909 -5.77963922136391 24.999514601591724 0.9685170442806178 1.0758868845867617 0.18205199103597036 0.09874409684133056 409.50745440475345 562503.0369239046 0.029885734705474426 0.04442590545278324 1.660966138097698e-06 5.77963922136391 0.10736984030614394 TQTES(ph)STPPGIPGGSR ddPTM_A459_Selumetinib_30min_R2 1 TQTESSTPPGIPGGSR 16 0 E9PER6;Q6A1A2;H3BQ10;O15530-4;O15530-5;O15530;O15530-3 E9PER6 PDPK1;PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2;3-phosphoinositide-dependent protein kinase 1 1 T(0.013)QT(0.002)ES(0.328)S(0.328)T(0.328)PPGIPGGSR 126.91 0.0010814 6181500.0 12569.0 16448.0 16797.0 17601.0 23477.0 14856.0 14424.0 15506.0 14928.0 17446.0 True False 11870.465297693558 17709.508711344257 15716.299307190806 15203.713436581444 20527.609372957064 16902.279150659135 15094.744580613782 15551.11989284351 17914.01712316988 16942.288649848328 0.7006411909880798 1.0452843224048598 0.9276373240950244 0.8973825054454819 1.2116196221896405 0.9976384832051867 0.8909507382728316 0.9178877903831917 1.0573552070446075 1.0 14.048341153910409 -4.754713249960569 24.97305967283836 0.9900120180007322 0.7006406924937392 0.47820500434180824 0.09183892425266152 213.84949338112008 793917.2062309314 0.02361203126313475 0.22423505000757984 1.7590846950645734e-05 4.754713249960569 -0.28937132550699307 TQTESS(ph)TPPGIPGGSR ddPTM_A459_Selumetinib_30min_R1 2 TQTESSTPPGIPGGSR 16 0 E9PER6;Q6A1A2;H3BQ10;O15530-4;O15530-5;O15530;O15530-3 E9PER6 PDPK1;PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2;3-phosphoinositide-dependent protein kinase 1 1 TQTES(0.007)S(0.497)T(0.497)PPGIPGGSR;TQTES(0.006)S(0.497)T(0.497)PPGIPGGSR 199.33 8.408799999999998e-07 15000200.0 3140.8 2995.1000000000004 3654.1000000000004 4189.2 3412.3 2956.5 3065.3 3024.0 1784.06 2650.7 True False 3213.9745290670608 2644.432299615786 3157.8932905345414 3457.634861023262 3103.658067490494 2926.76029428722 2834.0819531128127 2943.7936966636516 3027.4195174130687 2990.9431650044735 1.074568907451056 0.884146623231415 1.0558185549907693 1.1560349596339088 1.0376854043249104 0.9785409259967809 0.9475545995901844 0.9842359196615655 1.0121956019878233 1.0 11.546384780761196 -6.754396747366395 10.800732597957127 0.9811978834420632 1.0400657390039216 0.16270834335551188 0.06454945243562277 0.4049140688464627 554.150458408809 0.023443342624180203 0.022482266562725204 1.7603671377760049e-07 6.754396747366395 0.05886785556185847 TQTESS(ph)TPPGIPGGSR ddPTM_A459_Selumetinib_30min_R2 1 TQTESSTPPGIPGGSR 16 0 E9PER6;Q6A1A2;H3BQ10;O15530-4;O15530-5;O15530;O15530-3 E9PER6 PDPK1;PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2;3-phosphoinositide-dependent protein kinase 1 1 TQT(0.005)ES(0.071)S(0.462)T(0.462)PPGIPGGSR 137.52 0.00040705 6443800.0 24401.0 25710.0 29118.0 30425.0 27495.0 22568.0 27524.0 24080.0 20874.0 30116.0 True False 23044.89010494236 27681.874329320308 27244.579581281305 26281.062513947523 24040.8322915813 25676.53714809337 28803.920537771315 24150.068813341415 25049.383268290992 29246.472829234903 0.7879545078648453 0.9465030019500124 0.931550951130336 0.8986062239846186 0.8220079197909287 0.8779361975720708 0.9848681824284393 0.8257429521279195 0.8564924534507121 1.0 14.835975023438403 -11.780995803514648 2.2798768801209057 1.4467886417069482 0.8847706644446325 0.270814927242367 0.05818365947843481 8965729.036515763 1559912.0090258422 20626738.190302785 0.01468677584223527 1.6557859628622415e-12 11.780995803514648 -0.5620179772623157 TQTGDSS(ph)SISSFSYR ddPTM_A459_Selumetinib_30min_R1 2 TQTGDSSSISSFSYR 15 0 A0A087WXA6;A0A087WT45;Q4V328-4;Q4V328;Q4V328-3;Q4V328-2 A0A087WXA6 GRIPAP1 GRIP1-associated protein 1 1 TQTGDS(0.016)S(0.375)S(0.375)IS(0.18)S(0.054)FSYR;TQTGDS(0.108)S(0.346)S(0.346)IS(0.151)S(0.049)FSYR 142.4 0.00038158 28163000.0 5639.0 7569.5 6942.3 7580.3 5857.5 6882.1 7096.6 6789.3 4895.5 6108.6 True False 5770.377728416056 6683.259421034924 5999.573791324251 6256.542904854059 5327.690159225617 6812.872322446838 6561.297748494562 6609.225709245549 8307.305946826722 6892.698312802774 0.8371725362907477 0.9696143828928607 0.870424544794076 0.907705897011756 0.7729469530575206 0.9884187604428204 0.9519200537628848 0.9588734932688565 1.2052327796497924 1.0 12.75085315589737 -7.784112824859655 1.4929262147317728 1.091200057602426 0.8888455136500437 0.49951236463190063 0.07802639362022679 0.33672207299016726 1.3949850375754005 0.06067643171221006 0.023225709737700977 1.643944589277212e-08 7.784112824859655 -0.2023545439523824 TQTGDSS(ph)SISSFSYR ddPTM_A459_Selumetinib_30min_R2 1 TQTGDSSSISSFSYR 15 0 A0A087WXA6;A0A087WT45;Q4V328-4;Q4V328;Q4V328-3;Q4V328-2 A0A087WXA6 GRIPAP1 GRIP1-associated protein 1 1 TQTGDS(0.116)S(0.442)S(0.442)ISSFSYR 219.53 2.4228000000000004e-09 8991900.0 30429.0 27335.0 26583.0 28013.0 24179.0 28690.0 22333.0 24216.0 20155.0 24057.0 True False 28737.877996938278 29431.50660412176 24872.678721381988 24197.581074879607 21141.417856997436 32641.787078110563 23371.52875199997 24286.464550825396 24186.56317775245 23362.4119024075 1.2300903741011788 1.259780314081734 1.0646451584401204 1.0357484139891413 0.9049330157054036 1.3971925165289472 1.000390235804015 1.0395529644917643 1.035276806127197 1.0 14.511901603254524 -5.264501130380649 23.35867331249083 1.0646797905079786 1.244935370755881 0.27093251031596466 0.12131530638021343 133.30086422161523 1017005.6749307525 0.03152803056556442 0.07061185421021916 5.438747161227431e-06 5.264501130380649 0.18025558024790245 TQTGDSSSIS(ph)SFSYR ddPTM_A459_Selumetinib_30min_R2 1 TQTGDSSSISSFSYR 15 0 A0A087WXA6;A0A087WT45;Q4V328-4;Q4V328;Q4V328-3;Q4V328-2 A0A087WXA6 GRIPAP1 GRIP1-associated protein 1 1 TQT(0.022)GDS(0.01)S(0.31)S(0.31)IS(0.336)S(0.013)FSYR 209.66 1.3512e-06 8653600.0 34223.0 27399.0 26995.0 25244.0 25035.0 22573.0 24303.0 22526.0 21683.0 27172.0 True False 32321.02266552365 29500.415198329356 25258.17108993369 21805.723651671047 21889.879484260324 25682.225852707903 25433.137655480918 22591.54693061994 26020.205873639632 26387.473758665517 1.22486233282978 1.1179704229413612 0.9572030775260943 0.8263664741498854 0.8295557083054149 0.9732733829540612 0.9638337450597673 0.856146637500719 0.9860817337656176 1.0 14.687565618417496 -5.158561243407957 2.4705450517455376 0.9124166044412688 1.2159435765051139 0.7323478569317698 0.06152224343482974 0.15855979441187387 1.7708990805200955 0.017135356909721042 0.07030109390826678 6.941267103417975e-06 5.158561243407957 0.30352697206384505 TQTPPVS(ph)PAPQPT(ph)EERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 2 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.083)QT(0.293)PPVS(0.749)PAPQPT(0.862)EERLPS(0.005)S(0.006)PVY(0.002)EDAASFK;T(0.24)QT(0.358)PPVS(0.569)PAPQPT(0.647)EERLPS(0.072)S(0.069)PVY(0.042)EDAAS(0.002)FK 61.526 0.006525199999999999 14096300.0 1439.32 1548.3200000000002 1854.77 1828.95 1336.85 1407.9 1214.84 1713.06 951.77 1011.6899999999999 True False 1472.853355570809 1367.0419746055602 1602.9024215223328 1509.5582161435345 1215.9321535400372 1393.737804270921 1123.2036407267044 1667.624083996904 1615.0841754695673 1141.550266195109 1.2902220771056918 1.1975311250743566 1.4041452829448784 1.3223755982073653 1.065158661469065 1.2209167178563025 0.9839283244796958 1.4608415707836035 1.4148165203909853 1.0 10.156778672208727 TQTPPVS(ph)PAPQPTEER ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 TQTPPVS(0.991)PAPQPT(0.009)EER 176.17 1.2232e-06 9121900.0 22040.0 20231.0 23954.0 29033.0 26834.0 20424.0 20340.0 23989.0 32827.0 21917.0 True False 20815.105033110503 21782.652647082054 22412.825719143224 25078.65531528148 23462.873020996285 23237.220609387594 21285.85030294537 24058.804018407252 39393.31726301564 21284.199262795242 0.9779604473772845 1.0234189399437783 1.0530264936168314 1.1782757248997826 1.1023610863298654 1.0917592117268997 1.0000775711658092 1.130359837424658 1.8508244908172382 1.0 14.377495194765407 -8.028095287770839 24.737478402703328 1.4471390415345144 1.0664255831418854 0.3442330166618909 0.19788787675536978 605.8654226783177 533451.4034426631 0.12016785566714333 0.045661592422570126 9.373563206983644e-09 8.028095287770839 -0.38071345839262904 TQTPPVS(ph)PAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.013)QT(0.149)PPVS(0.838)PAPQPT(0.058)EERLPS(0.449)S(0.449)PVY(0.043)EDAASFK 86.70100000000002 1.5832e-06 2446500.0 13320.0 12530.0 12600.0 13905.0 12252.0 10774.0 12201.0 9156.2 6158.5 14866.0 True False 12579.727724184757 13491.010709699874 11789.329717842726 12011.115012537066 10712.794225730284 12258.020703365743 12768.37067582284 9182.843026109485 7390.372082867209 14436.779953493367 0.871366590382972 0.9344889063322851 0.8166176776137659 0.8319801958074905 0.7420487297195407 0.8490827416400141 0.8844334205380189 0.6360727984835323 0.5119127746405049 1.0 13.817461372247523 -6.079827015157108 0.6290834748763184 0.7356420857572427 0.912011010329249 0.11662169005241019 0.12840100507573604 2.0287811135792175 1.5781102210695397 0.08540511264739316 0.20942367710448204 8.320951388500407e-07 6.079827015157108 0.17636892457200637 TQTPPVSPAPQPT(ph)EER ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVSPAPQPTEER 16 0 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 TQTPPVS(0.46)PAPQPT(0.54)EER 127.49 0.0024156 8737500.0 17597.0 15345.0 19400.0 18129.0 18205.0 15078.0 17236.0 20385.0 20149.0 19151.0 True False 16619.029186372303 16521.91215804824 18151.825121122925 15659.79892573064 15917.925145235049 17154.85763554377 18037.508152486076 20444.316975081587 24179.363010098466 18598.06086972632 0.8935893533623466 0.8883674633489554 0.9760063292765231 0.8420124568589543 0.8558916575623235 0.9224003381701058 0.9698596148723923 1.0992714304081335 1.300101294402005 1.0 14.182864585857532 -7.709065285168853 2.4587576933808033 1.1626777744772492 0.8969389383503117 0.6598673916249505 0.07616586384481931 0.16059752506386898 1.9456168920559387 0.04561732980935024 0.020926078601139046 1.954045692448326e-08 7.709065285168853 -0.2657388361269375 TQTPPVSPAPQPT(ph)EERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.015)QT(0.056)PPVS(0.354)PAPQPT(0.512)EERLPS(0.377)S(0.376)PVY(0.308)EDAAS(0.002)FK 57.073 0.014717 40020000.0 95763.0 89892.0 93780.0 92781.0 79562.0 63397.0 53350.0 63062.0 42324.0 77493.0 True False 90440.8758296625 96786.42735166347 87746.29689994374 80144.06774384776 69566.7102666955 72129.36128933333 55830.880711019505 63245.49997952388 50789.982631366685 75255.57573900568 1.2017830564916685 1.2861030747718822 1.165977351688295 1.0649585357209397 0.9244060600633797 0.9584586999837142 0.7418836433415501 0.8404094893761225 0.6748999277809226 1.0 16.199510855681048 -6.165877327297104 0.9529959834733627 0.806858676173989 1.2625184683021549 0.7823145414298452 0.08822589234737668 0.2406526667035064 0.4577738192474544 0.03871383035692243 0.06896397029277633 6.825314577116588e-07 6.165877327297104 0.4556597921281659 TQTPPVSPAPQPT(ph)EERLPSSPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 4 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 TQTPPVS(0.002)PAPQPT(0.952)EERLPS(0.028)S(0.011)PVY(0.005)EDAAS(0.001)FK;TQTPPVS(0.001)PAPQPT(0.755)EERLPS(0.119)S(0.119)PVY(0.005)EDAASFK;T(0.001)QT(0.002)PPVS(0.024)PAPQPT(0.875)EERLPS(0.046)S(0.046)PVY(0.007)EDAASFK;TQTPPVS(0.009)PAPQPT(0.98)EERLPS(0.006)S(0.003)PVY(0.001)EDAASFK 80.685 2.4907e-05 265836000.0 9850.7 8740.3 12099.9 12490.0 9711.3 8158.8 8634.599999999999 8439.1 5088.69 7266.7 True False 10080.202143874456 7716.9816127447675 10456.800039993135 10308.855966337373 8832.91462966927 8076.729879597689 7983.285170243652 8215.267653939893 8635.13526678739 8199.451728652051 1.2293751432977325 0.9411582466884527 1.275304786959479 1.257261620348864 1.0772567388626308 0.9850329201127529 0.9736364618559763 1.0019289003473946 1.0531356915747052 1.0 13.001311729173345 -6.51918233627472 5.121966906915295 1.0029559234276406 1.1669416049210501 0.4567995867270135 0.08865982757562593 0.1792405988794515 14.236752656090852 0.02978150505956798 0.0315382812411142 3.02564286101369e-07 6.51918233627472 0.16398568149340953 TQTPPVSPAPQPTEERLPS(ph)S(ph)PVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 1 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 2 T(0.02)QT(0.063)PPVS(0.223)PAPQPT(0.293)EERLPS(0.645)S(0.645)PVY(0.109)EDAAS(0.001)FK 63.932 0.0012291 34991000.0 71058.0 78529.0 79085.0 71333.0 69654.0 52922.0 63499.0 44617.0 33820.0 68101.0 True False 67108.88082771176 84551.92178946677 73996.75720123749 61617.32234371141 60903.441805339244 60211.52512191589 66451.82932088144 44746.828083258035 40584.94500975382 66134.74718235232 1.014729528528679 1.2784795495828094 1.118878658403386 0.9316936250442587 0.9208992912214682 0.9104370650407958 1.0047944862880451 0.6766008791094081 0.6136705247825258 1.0 16.01312084214959 -6.264288687593717 0.711759062407916 0.7864090739100945 1.1787926794399988 0.47007299146535697 0.13356327298022927 0.6760049048405818 0.7354737491528162 0.08454367656283247 0.15253554736287864 5.44140827090356e-07 6.264288687593717 0.39238360552990426 TQTPPVSPAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 2 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 TQTPPVSPAPQPT(0.001)EERLPS(0.494)S(0.494)PVY(0.011)EDAASFK;TQTPPVSPAPQPT(0.041)EERLPS(0.472)S(0.472)PVY(0.015)EDAASFK 112.9 9.7299e-12 699120000.0 5476.5 5237.200000000001 6729.6 7460.0 5704.8 5090.799999999999 5086.8 4391.0 2956.9 3582.1 True False 5604.091794586015 4624.026189291776 5815.757283046788 6157.2510415433835 5188.801847264248 5039.591174076568 4703.098580593823 4274.53641602186 5017.643336568672 4041.8974276087497 1.3865002501811343 1.1440236354605917 1.4388681027186485 1.5233565798788986 1.2837539646160752 1.2468379676468113 1.1635868214934515 1.0575568758435177 1.2414078848945924 1.0 11.9808169951581 -7.032771701833602 1.7418997471759397 1.1131723775634608 1.3607132033272256 0.5289103456532216 0.10818891374533882 0.320328897520914 1.9493272832145339 0.053719385448771695 0.039788951735831427 9.273171636119022e-08 7.032771701833602 0.2475408257637648 TQTPPVSPAPQPTEERLPS(ph)SPVYEDAASFK ddPTM_A459_Selumetinib_30min_R2 6 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 TQTPPVS(0.003)PAPQPT(0.008)EERLPS(0.464)S(0.464)PVY(0.061)EDAASFK;TQTPPVSPAPQPT(0.12)EERLPS(0.426)S(0.426)PVY(0.028)EDAASFK;TQTPPVSPAPQPT(0.116)EERLPS(0.429)S(0.429)PVY(0.025)EDAASFK;TQTPPVS(0.002)PAPQPT(0.03)EERLPS(0.449)S(0.449)PVY(0.067)EDAAS(0.001)FK;TQTPPVS(0.001)PAPQPT(0.058)EERLPS(0.446)S(0.446)PVY(0.05)EDAASFK;TQTPPVSPAPQPT(0.001)EERLPS(0.469)S(0.469)PVY(0.06)EDAASFK 86.376 1.1839e-06 814954900.0 452938.0 455861.0 457546.0 542430.0 485919.0 316951.0 320262.0 307989.0 257988.0 483272.0 True False 427765.5192144741 490824.072875858 428107.9884984182 468550.0982560568 424873.51104902313 360608.1232552884 335154.8175871136 308885.19699967606 309592.8087870012 469318.68166854896 0.9114606682471222 1.0458225765291334 0.9121903841040034 0.9983623421727862 0.9052985266610062 0.7683651585597094 0.7141305698625756 0.6581566195096038 0.6596643621479522 1.0 18.840208363769833 -6.716703039011328 2.628891935437964 0.729993042825453 0.9684023968786619 0.4933710930424985 0.09841550363820768 0.20051737856867138 2.8341652332540828 0.03454356613311981 0.032884255714836746 1.9199811326815174e-07 6.716703039011328 0.23840935405320896 TQTPPVSPAPQPTEERLPSS(ph)PVYEDAASFK ddPTM_A459_Selumetinib_30min_R1 1 TQTPPVSPAPQPTEERLPSSPVYEDAASFK 30 1 Q14247-3;Q14247;Q14247-2;H0YEV2;H0YCD9 Q14247-3 CTTN Src substrate cortactin 1 TQTPPVSPAPQPT(0.003)EERLPS(0.17)S(0.754)PVY(0.073)EDAASFK 108.22 3.6062e-11 339980000.0 2731.6 2460.1 3270.3 3850.1 3041.1 2464.8 2583.9 2560.8 1402.6 2040.6 True False 2795.2409652316524 2172.0703483305374 2826.2112224720477 3177.7523103279063 2766.033041949814 2440.006349859341 2388.9943426901755 2492.879265349301 2380.1097581491495 2302.5308871272214 1.2139863056165845 0.9433403740527214 1.2274368340822572 1.3801127828919875 1.2013011670826645 1.0597062404247017 1.0375514856483994 1.082669196442168 1.0336928687713371 1.0 11.169004794032505 -6.785373414063691 6.720157902572965 1.046813761701531 1.1917809913187856 0.35483403972547367 0.10143779471511151 0.228936332426695 36.959643952730175 0.03887118583601832 0.035190482503341176 1.6391797714044423e-07 6.785373414063691 0.1449672296172546 TQTPQLHFLDT(ph)DDEVSPTSWGDSR ddPTM_A459_Selumetinib_30min_R2 1 TQTPQLHFLDTDDEVSPTSWGDSR 24 0 Q86US8 Q86US8 SMG6 Telomerase-binding protein EST1A 1 T(0.009)QT(0.007)PQLHFLDT(0.958)DDEVS(0.02)PT(0.003)S(0.001)WGDS(0.001)R 66.47399999999999 0.027981 0.0 4492.4 3326.2 5705.0 4529.4 7061.2 3365.3 3358.1 3190.7 4273.2 5564.4 True False 4242.730392502071 3581.3088445813005 5337.946511134347 3912.487906349186 6174.108928071062 3828.83952784822 3514.258303948912 3199.9844087511797 5127.959403183915 5403.74131395254 0.7851468354984495 0.6627461672405206 0.987824213078389 0.7240331612927297 1.1425618972783582 0.708553445732515 0.6503379972825577 0.5921794221512368 0.9489646349175613 1.0 12.399742896777452 -9.77948477513429 16.02948696304623 0.9999999999448594 0.7963317537492135 0.11556323349086706 0.1654497359486093 0.0 0.0 0.16120114147570722 0.03909701960438099 1.6615569251971522e-10 9.77948477513429 -0.20366824619564594 TQVAGGQLS(ph)FK ddPTM_A459_Selumetinib_30min_R2 3 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 1 TQVAGGQLS(1)FK;TQVAGGQLS(1)FK;TQVAGGQLS(1)FK 111.12 0.008431999999999999 13203100.0 73340.0 71111.0 73000.0 68236.0 63567.0 33825.0 39125.0 48862.0 35337.5 58113.0 True False 69264.05640328144 76564.98504209629 68303.25947639049 58942.1390863344 55581.145163809735 38484.08671722165 40944.39002471671 49004.18033046043 42405.98741224649 56435.12669429303 1.227321713628504 1.3566902304808484 1.2102969104045198 1.0444229071305493 0.9848679079767237 0.6819172556427225 0.7255125029932322 0.8683276392009226 0.7514112202132217 1.0 15.784305792758795 -6.081746474124376 1.4346030368078184 0.7969917156987903 1.2930206339133623 0.8054158465414816 0.09651868917627675 0.16219541590492328 0.6730342913993829 0.03423794874629551 0.05610149530918994 8.284256283894378e-07 6.081746474124376 0.49602891821457196 TQVLS(ph)PDSLFTAK ddPTM_A459_Selumetinib_30min_R2 1 TQVLSPDSLFTAK 13 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-1;H0Y8L4;H0Y948 A8MQ02 MLLT4 Afadin 1 T(0.432)QVLS(0.505)PDS(0.062)LFT(0.001)AK 154.81 0.00037465 3640600.0 24827.0 23536.0 22892.0 26180.0 28310.0 15275.0 22251.0 24106.0 17175.0 22832.0 True False 23447.214730355485 25341.135519832074 21419.153642925063 22614.238836980978 24753.444705388854 17378.99259735582 23285.71558952005 24176.144469036866 20610.479909595564 22172.780835339723 1.0574774045925952 1.1428938800244 0.9660111558396183 1.0199099068772486 1.116388823270015 0.7837985107243111 1.0501937380992146 1.090352385141701 0.929539693854994 1.0 14.436502099044896 -5.265266509161019 24.950072465379414 0.9974723565860062 1.1001856434692254 0.1801683947063748 0.08998130936744379 508.96241413851465 3318084.61422993 0.023272134046969862 0.051473718372966805 5.429170627497444e-06 5.265266509161019 0.10271328688321923 TQYNQVPS(ph)EDFER ddPTM_A459_Selumetinib_30min_R1 1 TQYNQVPSEDFER 13 0 P78310-7;P78310-2;P78310-6;P78310 P78310-7 CXADR Coxsackievirus and adenovirus receptor 1 TQYNQVPS(1)EDFER 102.15 0.0095328 5004200.0 524.33 505.07 500.45 601.79 323.05 546.56 704.91 611.92 173.03 446.74 True False 536.5458688314225 445.9361695993271 432.49163877507794 496.69867349737166 293.8301845391099 541.0621026367741 651.7380711737028 595.6898938037114 293.6192723888118 504.08343061610077 1.0643989392304474 0.8846475454555114 0.8579763041337782 0.9853501292242371 0.5828999064301416 1.073358237495482 1.2929170680677513 1.181728772706628 0.5824814992033055 1.0 8.97751872305306 TRDDGDEEGLLTHS(ph)EEELEHSQDTDADDGALQ ddPTM_A459_Selumetinib_30min_R1 4 TRDDGDEEGLLTHSEEELEHSQDTDADDGALQ 32 1 Q9UKM9-2;Q9UKM9 Q9UKM9-2 RALY RNA-binding protein Raly 1 TRDDGDEEGLLT(0.003)HS(0.794)EEELEHS(0.166)QDT(0.037)DADDGALQ;TRDDGDEEGLLT(0.002)HS(0.686)EEELEHS(0.172)QDT(0.139)DADDGALQ;TRDDGDEEGLLTHS(0.704)EEELEHS(0.148)QDT(0.148)DADDGALQ;TRDDGDEEGLLT(0.046)HS(0.698)EEELEHS(0.128)QDT(0.128)DADDGALQ 91.655 4.5925e-08 278401900.0 2421.64 2495.4200000000005 2681.43 2581.63 2233.1099999999997 2167.2200000000003 2638.82 2560.27 1406.6999999999998 2333.44 True False 2478.0595003088247 2203.255066310716 2317.3065340406774 2130.796783697002 2031.125594787591 2145.4197344783192 2439.77168287383 2492.363322670984 2387.0671586969956 2632.9597536303736 0.9411687728580092 0.8367978520267266 0.8801146811475308 0.8092781443996704 0.7714229554732226 0.8148319515785134 0.9266270323767112 0.946601374834715 0.9066098163504639 1.0 11.362469753755278 -7.35140265110313 5.105673935364399 0.9429059884273873 0.8391809312864846 0.5263937325458103 0.0478039809413543 0.19924247108239718 8.538152289677114 0.0214798483877512 0.014280421362964322 4.452432548447298e-08 7.35140265110313 -0.10372505714090263 TRDDGDEEGLLTHS(ph)EEELEHSQDTDADDGALQ ddPTM_A459_Selumetinib_30min_R2 3 TRDDGDEEGLLTHSEEELEHSQDTDADDGALQ 32 1 Q9UKM9-2;Q9UKM9 Q9UKM9-2 RALY RNA-binding protein Raly 1 TRDDGDEEGLLT(0.073)HS(0.679)EEELEHS(0.191)QDT(0.057)DADDGALQ;TRDDGDEEGLLT(0.188)HS(0.406)EEELEHS(0.203)QDT(0.203)DADDGALQ;TRDDGDEEGLLT(0.071)HS(0.786)EEELEHS(0.071)QDT(0.071)DADDGALQ 60.172 0.00042423 180858000.0 35605.6 26796.8 35612.3 38015.100000000006 37959.5 28413.6 34788.0 37227.6 35346.2 35106.100000000006 True False 33626.783292509965 28852.028394707522 33321.04338974051 32837.377800294744 33190.68824776435 32327.31548701992 36405.71093111426 37335.926152639055 42416.42765534479 34092.495676398066 0.986339739152317 0.846286780192555 0.9773717860381917 0.9631849223354971 0.9735482131553652 0.9482237907681201 1.0678511563563127 1.0951361996794615 1.2441573083401258 1.0 15.057166592643503 -7.424723172598972 2.059068657572093 1.129215639648884 0.9450380995449443 0.5597304120605374 0.0667785092933369 0.2271980101174224 1.8855822266235043 0.035576976015690306 0.019959909156588587 3.760770464262248e-08 7.424723172598972 -0.1841775401039396 TRDDGDEEGLLTHSEEELEHS(ph)QDTDADDGALQ ddPTM_A459_Selumetinib_30min_R2 1 TRDDGDEEGLLTHSEEELEHSQDTDADDGALQ 32 1 Q9UKM9-2;Q9UKM9 Q9UKM9-2 RALY RNA-binding protein Raly 1 TRDDGDEEGLLT(0.002)HS(0.307)EEELEHS(0.385)QDT(0.307)DADDGALQ 85.98200000000001 1.6644000000000005e-07 113890000.0 50451.0 37554.0 45680.0 54135.0 44666.0 37285.0 41045.0 50446.0 44898.0 42605.0 True False 47647.135391354714 40434.271044857865 42740.99853262348 46761.71961191618 39054.65776089364 42420.670310468886 42953.673829124535 50592.78950821515 53878.854554935766 41374.88294891594 1.15159565406343 0.9772661132305942 1.0330179927129761 1.1301958163761132 0.9439218911897106 1.0252758989758144 1.0381581956898311 1.2227899126791544 1.3022116490687847 1.0 15.336467610037102 -7.755792030295863 24.827579207366696 1.1968755986559447 1.0387681481271995 0.29360378630921125 0.0919837477078438 123.45826507855008 542770.218729511 0.042538911196005266 0.023677910849760696 1.7547205801128533e-08 7.755792030295863 -0.1581074505287452 TRDDGDEEGLLTHSEEELEHSQDT(ph)DADDGALQ ddPTM_A459_Selumetinib_30min_R2 1 TRDDGDEEGLLTHSEEELEHSQDTDADDGALQ 32 1 Q9UKM9-2;Q9UKM9 Q9UKM9-2 RALY RNA-binding protein Raly 1 TRDDGDEEGLLT(0.001)HS(0.095)EEELEHS(0.317)QDT(0.587)DADDGALQ 65.765 0.0001412 238920000.0 11430.0 7582.2 7737.2 11017.0 11763.0 7764.2 10278.0 10045.0 9284.3 9134.4 True False 10794.7663579153 8163.730359384383 7239.396975626405 9516.46559461496 10285.226777445745 8833.648073609826 10755.947365470636 10074.229286960734 11141.419425016484 8870.666137978596 1.2169059448307855 0.9203063481819521 0.8161052240070082 1.072801686659298 1.1594649846431366 0.9958269126813055 1.2125298368992217 1.1356790042891185 1.2559845283000737 1.0 13.11482673167695 -5.990136991761876 24.94423077073296 1.1297617504836097 0.9724304586531352 0.21554744021802508 0.12058169830833611 283.6120856495498 717267.1617879675 0.033841255284339046 0.05012522694061604 1.0229702605657247e-06 5.990136991761876 -0.15733129183047456 TRDELDQFLDK ddPTM_A459_Selumetinib_30min_R2 1 TRDELDQFLDK 11 1 Q14137;Q14137-2;A0A075B729 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 113.61 0.019724 1391900.0 17490.0 13727.0 14810.0 17274.0 15135.0 14287.0 14198.0 15545.0 11426.0 11933.0 False True 16517.975818017367 14779.816760738238 13857.140723908798 14921.25140068792 13233.605991383269 16254.904565526846 14858.235132803266 15590.233376386717 13711.519269114346 11588.463284342553 1.425381037392179 1.2753905671606691 1.1957703436513027 1.2875953467314665 1.1419638365048372 1.4026799038565563 1.2821575016662112 1.3453236200395138 1.1832042724457092 1.0 13.500401646579958 -8.579179379180113 4.194993010417158 1.0001158361335336 1.2878932658020985 0.5566176185563875 0.08091536206606356 0.20706952811399595 10.890592759988769 0.07727623894241278 0.02020734398058531 2.635242711359761e-09 8.579179379180113 0.2877774296685649 TRGVTGY(ph)FT(ph)FNLYLET(ph)PKPSIS(ph)S(ph)SNLNPR ddPTM_A459_Selumetinib_30min_R2 1 TRGVTGYFTFNLYLETPKPSISSSNLNPR 29 2 M0R1G9 M0R1G9 PSG5 5 T(0.068)RGVT(0.068)GY(0.879)FT(0.98)FNLY(0.337)LET(0.36)PKPS(0.36)IS(0.648)S(0.65)S(0.65)NLNPR 40.104 0.036727 49313000.0 9231.0 8451.5 12090.0 8913.9 10725.0 11182.0 10208.0 9673.8 7560.7 10891.0 True False 8717.97797462083 9099.702874144325 11312.142562596708 7699.811442664815 9377.629617283488 12722.21899991049 10682.692226768262 9701.949156416198 9073.05126360868 10576.548531783683 0.8242743791533083 0.8603660113503686 1.0695495348603077 0.7280079526441013 0.8866436521425385 1.2028705736733334 1.0100357592711464 0.9173076762481429 0.8578461334851508 1.0 13.368581285974642 -6.561437431381912 24.999408711477177 0.998946590244592 0.8744470181810248 0.22771137912806338 0.11424022144314541 265.21987141477825 171952.8577470717 0.0392034120236214 0.03920347522235418 2.745127804365866e-07 6.561437431381912 -0.12449957206356721 TRIT(ph)PEEMSLK ddPTM_A459_Selumetinib_30min_R2 2 TRITPEEMSLK 11 1 Q9H7U1-3;Q9H7U1-2;Q9H7U1 Q9H7U1-3 CCSER2 Serine-rich coiled-coil domain-containing protein 2 1 T(0.004)RIT(0.996)PEEMSLK;T(0.027)RIT(0.973)PEEMSLK 93.348 0.032844 7550300.0 40409.0 30544.0 34254.0 40568.0 43173.0 34295.0 41719.0 42805.0 36363.0 36287.0 True False 38163.229550043674 32886.62658556047 32050.134932935292 35042.56841629658 37749.22176848299 39018.82495098646 43659.01616463019 42929.55546325076 43636.616067110546 35239.30002505138 1.0829735415548463 0.9332372255459556 0.9094997604989619 0.9944172668408582 1.0712250737570645 1.1072531214651893 1.2389297214641974 1.2182295174062037 1.2382940647541119 1.0 15.104897647155772 -6.653833344977958 1.6801786247290778 1.1894267713400304 0.9708217594061904 0.5373739847105996 0.07890577168526737 0.2483302127311952 1.445649632668824 0.031518531487201205 0.031209208672179817 2.2190477879996745e-07 6.653833344977958 -0.21860501193383997 TRKS(ph)PSSDSWTCADTSTER ddPTM_A459_Selumetinib_30min_R1 1 TRKSPSSDSWTCADTSTER 19 2 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHH7;H0YIQ0 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 T(0.029)RKS(0.95)PS(0.019)S(0.002)DSWTCADTSTER 77.137 0.0093604 12082000.0 2379.3 3268.4 4578.7 4988.2 3715.6 3368.9 2637.6 2614.0 1590.6 2005.2 True False 2434.733060688121 2885.7342085620635 3956.9376889988 4117.104510110817 3379.5246360424594 3335.0119247164625 2438.643708456056 2544.668228531345 2699.1320271724176 2262.5869523020215 1.0760837536921855 1.2754136169776962 1.7488555235293375 1.8196447680925392 1.4936551422273665 1.4739817717605614 1.077812150368369 1.12467201578367 1.1929406843022066 1.0 11.14375752138585 -7.240100518947853 6.792051183126944 1.108784663259593 1.500987210573906 0.45620890781668066 0.20377059893669636 0.18289543420216836 37.76117624951943 0.08909917588082754 0.06673864310155837 5.75306765201558e-08 7.240100518947853 0.3922025473143129 TRLPPAGS(ph)TPR ddPTM_A459_Selumetinib_30min_R2 2 TRLPPAGSTPR 11 1 J3QSF9 J3QSF9 FDXR 1 TRLPPAGS(0.5)T(0.5)PR;TRLPPAGS(0.995)T(0.005)PR 82.831 0.021581 11561400.0 27004.0 20644.3 26744.0 31164.0 35974.0 23020.0 27171.0 25858.0 22308.5 30714.0 True False 25503.225785576942 22227.651428113095 25023.320156665537 26919.409439101437 31454.624508359546 26190.796045245916 28434.50533831509 25933.242498977663 26770.823351569878 29827.20701544432 0.8550323123573571 0.745213972485046 0.8389427861518726 0.9025119054949649 1.0545615113098776 0.8780840938839665 0.953307673882838 0.8694492409413195 0.8975303432771339 1.0 14.86434127128167 -5.733021683381875 3.267286762095427 0.9358829875902172 0.7997357218344207 0.4923657157433661 0.05869374520705128 0.1980910517162973 4.35319586321236 0.01666182268103973 0.029397909786024298 1.8491762913102666e-06 5.733021683381875 -0.1361472657557965 TRLS(ph)TASEETVQNR ddPTM_A459_Selumetinib_30min_R1 3 TRLSTASEETVQNR 14 1 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 T(0.097)RLS(0.876)T(0.026)AS(0.001)EET(0.001)VQNR;T(0.019)RLS(0.872)T(0.054)AS(0.002)EET(0.054)VQNR;T(0.125)RLS(0.85)T(0.025)ASEETVQNR 199.33 0.00039484 23385600.0 4478.1 5375.6 5988.3 6327.0 6223.7 6058.8 8143.799999999999 9345.0 6083.4 4572.8 True False 4582.431017134233 4746.222252951357 5175.121751377361 5222.108222499329 5660.767433883482 5997.853972950252 7529.506609389006 9097.14024316198 10323.085486043437 5159.763422843948 0.8881087448401845 0.9198526878070205 1.0029765567284377 1.012082879493924 1.0970982523775075 1.1624280962952303 1.4592736124399495 1.7630925098011252 2.000689690604764 1.0 12.333089203699323 -7.20648171134406 1.760716421526969 1.6584612549896858 0.9770294281664592 0.5506459265697672 0.24335705564217625 0.24713404674308032 1.500528513919154 0.12244950323777062 0.07918074692879173 6.216104239538801e-08 7.20648171134406 -0.6814318268232266 TRLS(ph)TASEETVQNR ddPTM_A459_Selumetinib_30min_R2 1 TRLSTASEETVQNR 14 1 O43379;O43379-4;H7C3R4;O43379-3;O43379-2 O43379 WDR62 WD repeat-containing protein 62 1 T(0.171)RLS(0.776)T(0.037)AS(0.001)EET(0.016)VQNR 132.25 0.0039067 5695400.0 12406.0 13143.0 14214.0 15136.0 13205.0 14093.0 13714.0 13626.0 16720.0 28751.0 True False 11716.52418515285 14151.025838594209 13299.48671503305 13074.45068894362 11546.069845802187 16034.18282648351 14351.72817377547 13665.649404094273 20064.467195833353 27920.883925930826 0.4196329964421871 0.5068258539426753 0.47632756721865394 0.46826779279724196 0.41352809160454485 0.5742720348331151 0.5140141054218795 0.48944186152368335 0.7186186242907223 1.0 14.769056994999982 -8.561785016492227 1.8644526234403012 1.0002330771033305 0.48085183269514764 0.9311149343236036 0.04434097217540754 0.09082399448559203 0.7126486710677992 0.04293747768573503 0.01211994359207347 2.7429316359552146e-09 8.561785016492227 -0.5193812444081829 down TRNS(ph)GIWESPELDR ddPTM_A459_Selumetinib_30min_R1 3 TRNSGIWESPELDR 14 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 T(0.014)RNS(0.986)GIWESPELDR;T(0.024)RNS(0.976)GIWESPELDR;T(0.002)RNS(0.998)GIWESPELDR 218.34 5.0373e-08 76021000.0 3924.7200000000003 4884.9 4965.0 4988.0 4588.6 4162.0 5040.0 4745.8 2552.5600000000004 4342.6 True False 4016.158339824269 4312.973637071603 4290.780270792811 4116.939436356354 4173.561940183131 4120.134058793645 4659.828742272723 4619.925967469036 4331.507888393835 4900.01501050606 0.8196216401813616 0.8801960050783948 0.875666760528897 0.8401891478963384 0.8517447255232177 0.8408411096618515 0.9509825443966279 0.9428391459135351 0.8839784937610811 1.0 12.258570453389828 -7.261906686435719 24.99923315863729 0.9396866446762734 0.8532988532479954 0.6836994172781685 0.030929024415050042 26.194247629718664 1401249.9928036926 0.012029533811478746 0.00868056704215979 5.471335086963156e-08 7.261906686435719 -0.08638779142827802 TRNS(ph)GIWESPELDR ddPTM_A459_Selumetinib_30min_R2 2 TRNSGIWESPELDR 14 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 T(0.004)RNS(0.994)GIWES(0.002)PELDR;T(0.031)RNS(0.969)GIWESPELDR 137.52 0.00032242 75475000.0 33807.0 35562.0 41283.0 47976.0 46884.0 32448.0 39063.0 29622.0 23556.3 41520.0 True False 31928.142280143697 38289.49105014739 38626.89672553185 41441.58603678378 40994.012771722046 36917.41746638312 40879.50690186605 29708.195115813905 28268.218218014907 40321.20971808452 0.7918448504739073 0.9496116638825476 0.9579796091337817 1.027786277409151 1.016686083040206 0.9155830820677296 1.0138462409160092 0.7367882889309604 0.7010756476717585 1.0 15.299251302814376 -7.762311740818505 24.99999994342248 0.7891989585048372 0.9572177020437637 0.2936315682280738 0.09788410115555576 24.35520356500896 697888.1082331835 0.04869284957297585 0.025532038773537838 1.7285751256848067e-08 7.762311740818505 0.16801874353892643 TRNS(ph)GIWESPELDRNLAEDASSTEAAGGYK ddPTM_A459_Selumetinib_30min_R1 1 TRNSGIWESPELDRNLAEDASSTEAAGGYK 30 2 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 T(0.175)RNS(0.607)GIWES(0.149)PELDRNLAEDAS(0.027)S(0.03)T(0.01)EAAGGYK 42.32100000000001 0.023124 14812000.0 1240.7 894.07 3633.7 3637.4 2017.7 1584.3 1113.2 1182.0 778.31 551.88 True False 1269.6058960180524 789.3918687581331 3140.2634984853617 3002.19637245441 1835.1993912538678 1568.3633804293058 1029.2304277575383 1150.6495203228956 1320.7352244867125 622.7191737664266 2.0388097066917426 1.2676530641952308 5.042824487789469 4.821107971183961 2.947073847355511 2.5185724906193068 1.6528002848095835 1.8477823853782418 2.1209162655108837 1.0 9.282437890817233 -6.958790460897497 2.442103275847286 1.7290775795133926 3.312983947259374 0.31389304020292896 1.0899609393255048 0.42053664656187956 5.0730169311580955 0.49908996238858433 0.40772495929895386 1.0995362174820717e-07 6.958790460897497 1.5839063677459815 TRPAS(ph)QPTPFALHHAASCEVDPSSGDSISLAR ddPTM_A459_Selumetinib_30min_R2 1 TRPASQPTPFALHHAASCEVDPSSGDSISLAR 32 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 T(0.195)RPAS(0.471)QPT(0.334)PFALHHAASCEVDPSSGDSISLAR 71.289 4.1872e-05 4753900.0 5091.9 6187.5 6367.7 6554.3 8889.7 6162.9 4781.4 4490.1 5913.8 5303.6 True False 4808.91258249072 6662.061354051713 5958.009114627546 5661.5930332018515 7772.896411073661 7011.7835337639435 5003.744574164356 4503.16544762393 7096.725245377948 5150.471287592319 0.9336839900603995 1.293485776748406 1.1567891134507666 1.0992378594247956 1.5091621673144482 1.3613867823427337 0.9715119830331967 0.8743210467889079 1.3778788093575494 1.0 12.330488735047943 -7.271970425258258 24.822062922469424 1.0454547141003319 1.232723274205324 0.1607331987972228 0.18894440518177688 1197.0593056810683 2821501.5883873147 0.07955022438467349 0.05429639666957448 5.346007635923931e-08 7.271970425258258 0.18726856010499215 TRPDGNCFYR ddPTM_A459_Selumetinib_30min_R2 1 TRPDGNCFYR 10 1 J3KR44;F5H6Q1;F5GYJ8;Q96FW1;F5GYN4 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 135.86 0.0054077 3046200.0 14588.0 10126.0 11555.0 10439.0 9703.2 9573.4 9692.5 19529.0 9005.2 13509.0 False True 13777.257360390937 10902.631639778196 10811.563880132755 9017.190191720569 8484.197268291387 10892.048951327419 10143.220455324392 19585.826156799998 10806.491626310919 13118.960069402792 1.0501790757427096 0.8310591374697668 0.82411744703366 0.6873403184411898 0.6467126375419793 0.8302524661791467 0.773172599174329 1.492940450552922 0.8237308116757502 1.0 13.679365742632134 TRPGS(ph)FQSLSDALSDTPAK ddPTM_A459_Selumetinib_30min_R1 1 TRPGSFQSLSDALSDTPAK 19 1 G3V4K3;Q9H9C1-2;Q9H9C1 G3V4K3 VIPAS39 Spermatogenesis-defective protein 39 homolog 1 T(0.337)RPGS(0.659)FQS(0.003)LS(0.001)DALSDTPAK 81.94 0.0029866 50421000.0 2546.0 2588.7 2939.5 3421.0 3254.9 2300.8 2667.6 2524.6 1215.7 1917.6 True False 2605.316846346386 2285.6138005460184 2540.332045517716 2823.586570123312 2960.4948696992687 2277.6560409592544 2466.3807843029194 2457.6394069434723 2062.9541087850566 2163.7426390057635 1.2040788952347516 1.0563242408516083 1.1740453784674663 1.3049549050901663 1.3682287423330584 1.0526464653882468 1.139867902883412 1.1358279689273738 0.9534193538529984 1.0 11.07931319625264 -7.9288110201850746 1.1657680183595485 0.97745178549543 1.1998715341007848 0.43222259959617504 0.09339101498045518 0.5149731180089226 1.2638865153541996 0.09094260281735679 0.032814861253930384 1.1781185109678853e-08 7.9288110201850746 0.22241974860535485 TRPGS(ph)FQSLSDALSDTPAK ddPTM_A459_Selumetinib_30min_R2 1 TRPGSFQSLSDALSDTPAK 19 1 G3V4K3;Q9H9C1-2;Q9H9C1 G3V4K3 VIPAS39 Spermatogenesis-defective protein 39 homolog 1 T(0.025)RPGS(0.804)FQS(0.167)LS(0.005)DALSDTPAK 86.91799999999998 0.0019084 6029700.0 57036.0 37632.0 54749.0 68842.0 66204.0 45585.0 51103.0 59700.0 42152.0 48864.0 True False 53866.16745319832 40518.25339404829 51226.50894620408 59465.60084092613 57886.86164873061 51863.91997057057 53479.39075867344 59873.71711613294 50583.57782528515 47453.169356080965 1.1351437255748977 0.8538576863013263 1.0795171248059023 1.2531428700727196 1.2198734549078671 1.0929495474030837 1.1269930224759632 1.261743270862483 1.065968374961725 1.0 15.534216826365984 -5.520017050697166 24.942803358015237 1.15754735364785 0.9875473697313168 0.2585315932783201 0.10092163902786715 112.65324668709698 981895.4662682535 0.02573730589209137 0.045657890080852456 3.0198331573679746e-06 5.520017050697166 -0.16999998391653315 TRPGSFQSLSDALSDT(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 TRPGSFQSLSDALSDTPAK 19 1 G3V4K3;Q9H9C1-2;Q9H9C1 G3V4K3 VIPAS39 Spermatogenesis-defective protein 39 homolog 1 TRPGS(0.002)FQS(0.003)LS(0.001)DALS(0.019)DT(0.975)PAK 197.15 3.0601e-14 18412000.0 3720.8 3424.4 3658.9 3725.3 3625.6 2903.1 3407.7 3146.6 1602.8 2878.8 True False 3807.4874005835172 3023.469656039632 3162.0414768990536 3074.746287541764 3297.6651201516693 2873.897449803898 3150.6544454449886 3063.1419464027276 2719.834536119673 3248.322021886625 1.1721397616767468 0.9307789177513875 0.9734384262378458 0.9465644929365568 1.015190334558144 0.8847329268588767 0.9699329143528354 0.9429920819930455 0.8373044660578305 1.0 11.665478945618098 -4.759283282656221 24.99935775796011 0.9448642033967958 1.1721400534343198 0.6525590611348011 0.049819987983130906 34.31308809364135 397756.6098542686 0.01192447768143503 0.07651863561674924 1.740671093851554e-05 4.759283282656221 0.22727585003752404 TRPWLQELSMGS(ph)PGPVTNK ddPTM_A459_Selumetinib_30min_R1 2 TRPWLQELSMGSPGPVTNK 19 1 A0A1B0GV70;Q96N21-2;Q96N21 A0A1B0GV70 ENTHD2 AP-4 complex accessory subunit tepsin 1 TRPWLQELS(0.001)MGS(0.999)PGPVTNK;TRPWLQELSMGS(0.997)PGPVT(0.003)NK 164.27 2.0260000000000005e-07 110265000.0 8737.9 10371.3 12484.2 11863.4 9164.7 9528.6 9262.7 8769.8 5362.700000000001 8043.4 True False 8941.47606900632 9157.023374513437 10788.91421080193 9791.679893598624 8335.754503159204 9432.750935276581 8564.007081557445 8537.196415674905 9100.110223888805 9075.848739350724 0.9851944788632498 1.0089440268887206 1.188749892230328 1.078872089520865 0.918454542660826 1.0393243878534923 0.9436039898313802 0.9406499227625567 1.002673191812121 1.0 13.147816849511136 -6.243059451421806 24.120706770927615 0.972884819996985 1.070212542481674 0.35614382198214645 0.0600032535352042 591.4251636394382 776149.4707897628 0.01844650882886798 0.023762305525734488 5.714004111969029e-07 6.243059451421806 0.09732772248468902 TRPWLQELSMGS(ph)PGPVTNK ddPTM_A459_Selumetinib_30min_R2 3 TRPWLQELSMGSPGPVTNK 19 1 A0A1B0GV70;Q96N21-2;Q96N21 A0A1B0GV70 ENTHD2 AP-4 complex accessory subunit tepsin 1 TRPWLQELSMGS(0.999)PGPVT(0.001)NK;TRPWLQELSMGS(1)PGPVTNK;TRPWLQELS(0.002)MGS(0.998)PGPVTNK 141.91 5.3479e-05 13255000.0 131364.0 132491.0 136732.0 139315.0 161177.0 121969.0 125713.0 119584.0 101001.0 135842.0 True False 124063.31477175726 142652.63367428936 127934.81198254558 120340.05666822028 140928.50431933795 138769.12262565573 131558.90359558375 119931.9696418031 121204.02220372966 131919.88850009732 0.9404443574227682 1.0813580521953225 0.969791692800371 0.9122207275677882 1.0682885342132016 1.0519196476242727 0.9972636051423489 0.909127281757175 0.9187698957435083 1.0 17.00930255894623 -7.6786215988181326 6.803615790454996 0.9357853667483385 1.006155053630333 0.19360433443993463 0.05588665965732015 0.3146431991674811 21.140357954286277 0.02712954443077931 0.01545154894628688 2.0959378530810505e-08 7.6786215988181326 0.07036968688199452 TRS(ph)CLVEGDAK ddPTM_A459_Selumetinib_30min_R2 2 TRSCLVEGDAK 11 1 Q05209-2;Q05209-3;Q05209 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 T(0.036)RS(0.964)CLVEGDAK;T(0.152)RS(0.848)CLVEGDAK 116.58 0.0032162 9424700.0 57261.0 57480.0 63903.0 68826.0 67892.0 75962.0 85988.0 80337.0 59369.0 76863.0 True False 54078.6628539447 61888.53117266949 59791.55055232566 59451.78006852767 59362.7999978191 86425.07598561994 89986.61238198954 80570.76736949371 71244.45890845875 74643.76547594245 0.724490016133687 0.8291185576994512 0.8010253792943547 0.7964734856213661 0.7952814226253313 1.1578338181971084 1.2055476007703827 1.0794038437873492 0.9544596049541567 1.0 16.1877341457022 -6.753368536942097 24.95233667515672 1.0922928821924605 0.792543492227257 0.8047196060347297 0.07132200256047663 76.13291160062529 235377.088658641 0.024848984297984315 0.024432172916370256 1.764539818451388e-07 6.753368536942097 -0.2997493899652035 TRS(ph)EGGGTGESSQGGTSK ddPTM_A459_Selumetinib_30min_R1 1 TRSEGGGTGESSQGGTSK 18 1 F5H0R1;Q9H6E5 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 T(0.102)RS(0.568)EGGGT(0.273)GES(0.034)S(0.023)QGGTSK 84.32700000000001 0.0044291 1679900.0 277.13 523.79 661.1 722.01 480.08 410.87 478.21 439.37 319.65 407.45 True False 283.5865897988901 462.464423296635 571.3262511623619 595.9245073062647 436.65684876500796 406.7370208401118 442.13823469092046 427.7164803251025 542.4227036877053 459.7501763990916 0.6168275823622945 1.0059037430258368 1.2426884871196122 1.2961920144843302 0.9497698340978185 0.884691386147591 0.9616923655231339 0.9303236894330589 1.1798205450101857 1.0 8.844706317952005 TRS(ph)EITFGQVK ddPTM_A459_Selumetinib_30min_R2 1 TRSEITFGQVK 11 1 F5H5A3;Q8IVH8-3;Q8IVH8-2;Q8IVH8;H7C1A4 F5H5A3 MAP4K3 Mitogen-activated protein kinase kinase kinase kinase;Mitogen-activated protein kinase kinase kinase kinase 3 1 T(0.259)RS(0.738)EIT(0.003)FGQVK 97.203 0.010709 6248300.0 39936.0 41921.0 32166.0 42563.0 34591.0 54087.0 40915.0 38577.0 35157.0 41667.0 True False 37716.51699647466 45136.20590273969 30096.47457969279 36765.8459747296 30245.369332536422 61536.99329709885 42817.628571534435 38689.25268323386 42189.38236865511 40463.96544613263 0.9321013543935656 1.1154666974700478 0.7437846055834174 0.9086070919982837 0.7474642932067634 1.5207850396921563 1.0581668924301328 0.956140908501384 1.042640826312968 1.0 15.304350089686311 TRS(ph)MDDLLSACDTSSPLTR ddPTM_A459_Selumetinib_30min_R1 1 TRSMDDLLSACDTSSPLTR 19 1 J3QR65;Q9NYA4 J3QR65 MTMR4 Myotubularin-related protein 4 1 T(0.122)RS(0.878)MDDLLSACDTSSPLTR 85.97399999999998 0.028886 0.0 745.69 891.05 1137.3 1039.3 1175.7 853.11 967.29 727.18 377.36 619.43 True False 763.0631261398418 786.7254517620934 982.8609067417245 857.8057650772163 1069.358142586694 844.5284879619038 894.3265365303533 707.8928241864667 640.3523587160719 698.9398742591467 1.0917435880284605 1.1255981819552026 1.4062166760531796 1.227295503760552 1.5299715783423837 1.2082991957742808 1.279547167742161 1.0128093277505592 0.9161766015922677 1.0 9.44902454403201 -7.811793547056347 4.216458440437824 0.9605977773958494 1.2742870978486824 0.544997540779007 0.12203468651696141 0.1665318745281957 6.102682330403569 0.0726371629934796 0.034136197680854914 1.5424335137534474e-08 7.811793547056347 0.31368932045283304 TRS(ph)PDVISSASTALSQDIPEIASEALSR ddPTM_A459_Selumetinib_30min_R2 1 TRSPDVISSASTALSQDIPEIASEALSR 28 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 T(0.135)RS(0.863)PDVIS(0.002)SASTALSQDIPEIASEALSR 117.83 2.2692e-12 313260000.0 24851.0 31856.0 39172.0 41257.0 53792.0 32540.0 28587.0 34919.0 28883.0 29566.0 True False 23469.88090643509 34299.252766815545 36651.716167248844 35637.725427705285 47034.1680534185 37022.089631290226 29916.352144065855 35020.608508848345 34660.40705844827 28712.352758306515 0.8174140623026871 1.1945817556484546 1.276513857146223 1.2411983694855955 1.6381161254649 1.2894133038463627 1.0419331496758315 1.219705288648519 1.2071601150282252 1.0 14.809383932792851 -9.1365971026849 0.8230147316085165 0.9988062752101011 1.2353886021490814 0.09428955099663294 0.1947525087303577 5.670031370775508 5.46379596510353 0.22780354865731267 0.06930655539974817 7.301345458869427e-10 9.1365971026849 0.2365823269389803 TRS(ph)YDNLTTACDNTVPLASR ddPTM_A459_Selumetinib_30min_R1 1 TRSYDNLTTACDNTVPLASR 20 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 T(0.01)RS(0.99)YDNLTTACDNTVPLASR 200.27 4.8553000000000014e-15 8390200.0 566.25 823.09 948.74 1108.6 964.01 855.94 756.87 700.06 299.57 599.76 True False 579.4425232693018 726.7222401558399 819.9063190557849 915.0038209993284 876.8154657097891 847.3300207313389 699.7786865404674 681.4921346846422 508.34841027287933 676.7450381571215 0.8562198325786191 1.0738493807576541 1.2115438944162977 1.3520657993903011 1.2956363420077515 1.2520668389955927 1.0340359324186108 1.0070146011568075 0.7511668081929178 1.0 9.402468594524004 -7.69002166018654 2.1619445816415523 0.8870785264733951 1.1821362853383144 0.38830507773134404 0.14408714924946506 0.3407602670410657 3.1683230963869438 0.10138132149733531 0.045574844902026276 2.041636116707687e-08 7.69002166018654 0.29505775886491925 TRS(ph)YDNLTTACDNTVPLASR ddPTM_A459_Selumetinib_30min_R2 1 TRSYDNLTTACDNTVPLASR 20 1 Q13615-3;Q13615-2;Q13615;G5E953 Q13615-3 MTMR3 Myotubularin-related protein 3 1 T(0.114)RS(0.494)Y(0.39)DNLT(0.001)TACDNTVPLASR 79.695 0.0024156 18264000.0 12615.0 20652.0 22451.0 22744.0 24174.0 14919.0 10300.0 15930.0 10219.0 16238.0 True False 11913.90880184615 22235.941993353696 21006.527102800566 19646.227964411588 21137.046001698007 16973.956828802075 10778.97040906281 15976.353662646536 12263.085542716564 15769.166748609254 0.7555192352124049 1.4100898511530275 1.3321266391360354 1.2458634167302636 1.3404034809614889 1.0764016323373 0.683547240060319 1.0131387356948047 0.7776622403842673 1.0 13.944818808897326 -7.0172370688640875 6.390529123832601 0.8698002511434877 1.2338092563018628 0.425559254551388 0.19021663160750002 0.15018251418036685 25.385525856738443 0.06871803649014498 0.05587347857418027 9.610875051464515e-08 7.0172370688640875 0.3640090051583751 TRSDIVSR ddPTM_A459_Selumetinib_30min_R2 1 TRSDIVSR 8 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 105.1 0.040288 2799000.0 3385.0 3014.0 5326.5 3911.4 3271.9 992.61 2217.3 2382.2 1206.3 3388.0 False True 3196.875251228631 3245.164108462521 4983.798789054708 3378.660572458649 2860.854670842876 1129.3330174835594 2320.4088434965965 2389.131807605559 1447.5937068381447 3290.179636918842 0.9716415527458593 0.9863182155918768 1.5147497519989188 1.0268924330291787 0.8695132140328921 0.3432435739408889 0.7052529343563723 0.726140232830239 0.4399740642106017 1.0 11.683950638901331 -6.382452692951344 3.0114281476258347 0.6293186664219736 1.1477513492806553 0.5109236722769872 0.22003756307358383 0.2057252634328601 3.568360965018046 0.07175531151947812 0.08287947952091029 4.145217348116662e-07 6.382452692951344 0.5184326828586816 TRSEPLPPS(ph)ATAPPPPGPMQPR ddPTM_A459_Selumetinib_30min_R2 1 TRSEPLPPSATAPPPPGPMQPR 22 1 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;Q8WUI4-10 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.014)RS(0.014)EPLPPS(0.856)AT(0.116)APPPPGPMQPR 102.37 5.6787e-05 4679500.0 6311.6 7513.6 7012.3 8534.6 7572.4 5163.6 6038.7 5770.0 4692.7 7109.7 True False 5960.8265393366755 8089.868959968153 6561.136252414964 7372.172756993813 6621.087413885082 5874.83902950616 6319.511515457043 5786.789744725082 5631.371124993255 6904.424487780964 0.8633343082954689 1.1716934516823403 0.9502799638154444 1.067746163353751 0.9589629701364227 0.8508803362109466 0.9152843262520917 0.8381277476444553 0.8156177440942858 1.0 12.753305449583154 -6.565239860489575 4.260056714834075 0.8765295689957509 1.0199744953059084 0.3219966842464811 0.08801011338290761 0.21838739751421726 8.686298592199892 0.02767232729316628 0.028311134218602558 2.721197977539462e-07 6.565239860489575 0.1434449263101576 TRSPDVISS(ph)ASTALSQDIPEIASEALSR ddPTM_A459_Selumetinib_30min_R1 1 TRSPDVISSASTALSQDIPEIASEALSR 28 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 T(0.044)RS(0.044)PDVIS(0.341)S(0.557)AS(0.012)T(0.001)ALSQDIPEIASEALSR 126.86 1.9276e-12 10958000.0 187.5 305.84 276.15 318.39 145.05 391.47 237.04 269.07 170.9 240.56 True False 191.86838518851042 270.0321106188414 238.65034678337042 262.78916342050894 131.93025311065745 387.5321672263211 219.15988195800114 261.9333895374633 290.0048179578564 271.43821925282975 0.7068583993685708 0.994819783898307 0.8792068686579496 0.9681361900467499 0.4860415510896484 1.427699342756726 0.8074024452461713 0.9649834509615861 1.068400827105828 1.0 8.084480060290147 -6.753320314482964 24.999997894985906 1.0361152730313894 0.8304085176071401 0.27221460021564525 0.19881873585231286 295.48897835586104 909860.3570279481 0.06440495931761381 0.06333055162565623 1.764735757329431e-07 6.753320314482964 -0.20570675542424932 TRTDSYSAGQS(ph)VEILDGVELGEPAHK ddPTM_A459_Selumetinib_30min_R1 1 TRTDSYSAGQSVEILDGVELGEPAHK 26 1 B1AKQ2;B1AKP8;P42345 B1AKQ2 MTOR Serine/threonine-protein kinase mTOR 1 T(0.047)RT(0.047)DS(0.208)Y(0.168)S(0.208)AGQS(0.323)VEILDGVELGEPAHK 93.388 7.729299999999999e-06 8372100.0 1050.0 1739.0 1667.7 1625.0 1382.6 1495.0 1503.6 1531.3 924.74 942.05 True False 1074.4629570556585 1535.397071560833 1441.2355000203768 1341.2242550278818 1257.544074117856 1479.9616573513924 1390.1822414446951 1490.6849496365905 1569.2162396626575 1062.9712938440653 1.0108108876299335 1.4444388860289121 1.3558555234435161 1.2617690268733028 1.1830461287154328 1.392287511358231 1.307826701902103 1.4023755469875083 1.4762545787928463 1.0 10.053886921241347 -6.7788635509139015 24.996976627918965 1.3404021856947719 1.2683235670223931 0.022732669148064932 0.15944589270913515 902.8487377762212 1295231.9297405088 0.054062066613476296 0.04779119291309325 1.6639353528328446e-07 6.7788635509139015 -0.07207861867237875 TRTFS(ph)ATVR ddPTM_A459_Selumetinib_30min_R1 1 TRTFSATVR 9 1 H3BTK3;I3L3X8;H3BSW7;H3BUY4;H3BPY5;H3BNU9;Q9Y2V2 H3BTK3 CARHSP1 Calcium-regulated heat stable protein 1 1 T(0.001)RT(0.078)FS(0.922)ATVR 115.91 0.038049 127190000.0 2673.2 1993.6 9377.4 9413.3 5852.9 3768.6 2941.6 3372.6 2727.2 1946.0 True False 2735.480358858273 1760.1883852005035 8104.00058637109 7769.4438645255095 5323.50622841342 3730.691305615025 2719.712743704253 3283.147692251268 4627.859213192896 2195.78805564519 1.245785244083817 0.8016203479544414 3.6907025546187726 3.5383396154974567 2.4244171538902055 1.6990215863610905 1.2386043984127229 1.495202455360191 2.1076074265433093 1.0 11.100523092271981 -6.835442698419574 4.505529357084044 1.5009750062816816 2.396926303450626 0.18800394828090983 0.8684924107768113 0.4139431724017213 15.856518723753817 0.34872211367238326 0.31077747224373636 1.4606874624096564e-07 6.835442698419574 0.8959512971689445 TRVYSGS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 TRVYSGSR 8 1 H0Y5R1;Q8WYA1-6;Q8WYA1-8;Q8WYA1-7;Q8WYA1-4;Q8WYA1-3;Q8WYA1-5;Q8WYA1-2;Q8WYA1;Q8WYA1-9 H0Y5R1 ARNTL2 Aryl hydrocarbon receptor nuclear translocator-like protein 2 1 TRVYS(0.136)GS(0.864)R 78.098 0.028486 19133000.0 204.58 291.3 188.64 187.83 375.44 136.67 459.39 241.63 0.0 0.0 True False 209.34631595661583 257.19446057830396 163.02372412534854 155.0290165057766 341.4815182893155 135.29522388643133 424.73784244298906 235.22118747514494 0.0 0.0 0.0 TS(ph)DDEVGSPKEESR ddPTM_A459_Selumetinib_30min_R1 1 TSDDEVGSPKEESR 14 1 Q6ULP2-7;Q6ULP2-8;Q6ULP2-6;Q6ULP2;Q6ULP2-9;B8ZZI9 Q6ULP2-7 AFTPH Aftiphilin 1 T(0.098)S(0.548)DDEVGS(0.355)PKEESR 165.78 0.0011625 19400000.0 1851.8 2331.0 2975.0 2746.2 1877.8 2152.2 2135.0 1992.3 1365.7 2253.6 True False 1894.9433370244462 2058.0854363475005 2571.011340505258 2266.627722558504 1707.9533215525173 2130.5508220412507 1973.955231101638 1939.4577320975527 2317.493153218518 2542.8715119229178 0.7451982249749974 0.8093548677932129 1.0110661621912076 0.8913654158028935 0.67166324116037 0.8378523303484294 0.77627014257159 0.7627037870391399 0.911368562018311 1.0 11.312242850978437 -8.515361762897955 4.673698652356563 0.9997626493398147 0.8175867882909669 0.32635100574378173 0.08642257899646717 0.20259036731611135 14.817962894116874 0.08883998162695084 0.023154986477639188 3.0523774544852754e-09 8.515361762897955 -0.18217586104884786 TS(ph)DSDQQAYLVQR ddPTM_A459_Selumetinib_30min_R1 1 TSDSDQQAYLVQR 13 0 Q96CV9-3;Q96CV9-2;Q96CV9 Q96CV9-3 OPTN Optineurin 1 T(0.128)S(0.872)DSDQQAYLVQR 177.63 0.00010452 23154000.0 2078.1 2573.8 2626.5 3292.9 2762.8 2470.2 2851.3 2613.2 1926.7 1921.9 True False 2126.5156867212977 2272.458299472841 2269.835726331785 2717.8568303884977 2512.905227811956 2445.352030762148 2636.224145405201 2543.8894471301123 3269.469179399661 2168.5945858913096 0.9805962352558779 1.0478944816413636 1.0466851393520675 1.2532802802656804 1.1587713278271108 1.1276206473406318 1.2156371516171114 1.1730590234248663 1.5076442598679103 1.0 11.082544654134896 -5.1399822697651265 0.6654957093235748 1.2240831155295069 0.885999759898797 0.28683496702382116 0.12419432989258125 2.768722274892291 1.2717558832356965 0.0586162462980667 0.6614169148493422 7.244655360480932e-06 5.1399822697651265 -0.3380833556307099 TS(ph)DSDQQAYLVQR ddPTM_A459_Selumetinib_30min_R2 2 TSDSDQQAYLVQR 13 0 Q96CV9-3;Q96CV9-2;Q96CV9 Q96CV9-3 OPTN Optineurin 1 T(0.246)S(0.735)DS(0.019)DQQAYLVQR;T(0.1)S(0.79)DS(0.11)DQQAYLVQR 137.73 0.0010257 68142000.0 54732.0 49879.0 58055.0 59339.0 56452.0 41206.0 42704.0 57228.0 40337.0 64607.0 True False 51690.214549555574 53704.55891373658 54319.80450550473 51256.925834515445 49359.99507271678 46881.752469174746 44689.8206163707 57394.524005394574 48405.52710994796 62741.62804085469 0.8238583563036824 0.8559637451353104 0.8657697640573493 0.8169524354889087 0.7867184294385164 0.7472192535177337 0.7122834075531254 0.914775816273395 0.7715057549738481 1.0 15.937135344752544 -10.775760034129341 3.1810564886366968 1.000788919615801 0.8113183446544893 0.5026140439421178 0.056530897328288726 15303358.095304042 21861569.43470549 118644.8059886322 0.01449689491313347 1.675868607768574e-11 10.775760034129341 -0.1894705749613118 TS(ph)DTETEPSK ddPTM_A459_Selumetinib_30min_R1 1 TSDTETEPSK 10 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 T(0.037)S(0.933)DT(0.029)ET(0.001)EPSK 143.0 0.0011383 13420000.0 2859.6 9954.5 3372.1 3492.3 3364.8 3695.0 4000.6 3695.1 2102.2 4009.3 True False 2926.2231161870104 8789.022512278498 2914.1873416194207 2882.435363590074 3060.4544341036913 3657.831654791569 3698.8315210984633 3597.0939446236307 3567.279861386811 4523.932708889137 0.6468317069432167 1.9427836525969602 0.6441712397475087 0.6371525725673013 0.6765030850459298 0.8085512960005452 0.817614177556306 0.7951254309233318 0.7885351288221892 1.0 12.143361754822282 TS(ph)DTETEPSK ddPTM_A459_Selumetinib_30min_R2 1 TSDTETEPSK 10 0 P46013;P46013-2 P46013;P46013-2 MKI67 Antigen KI-67 1 T(0.167)S(0.833)DTETEPSK 110.08 0.0096796 7446400.0 33670.0 30808.0 31314.0 23956.0 24248.0 19112.0 31629.0 38618.0 23647.0 41320.0 True False 31798.756191689256 33170.87453666666 29299.29133210534 20693.15147359497 21201.74946012959 21744.50451853779 33099.81117167452 38730.37198644594 28377.060752384637 40126.98423774692 0.7924531782225636 0.8266475830860787 0.7301642993779703 0.5156916690023567 0.5283663814482572 0.5418923183886574 0.8248766210678242 0.9651951852891252 0.7071814962284336 1.0 15.292285113321554 -7.437161223069311 6.09563448863454 0.8806845646448173 0.655608999109224 0.4326599363851935 0.12404002370663939 0.2537356640256245 14.530474236445277 0.058311157082550774 0.03869948732617138 3.654590971070593e-08 7.437161223069311 -0.22507556553559327 TS(ph)DVGGYYYEK ddPTM_A459_Selumetinib_30min_R2 1 TSDVGGYYYEK 11 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.217)S(0.783)DVGGYYYEK 92.781 0.024525 58665000.0 149900.0 131270.0 129760.0 158060.0 153270.0 150270.0 163520.0 145010.0 127340.0 149930.0 True False 141569.1580972444 141337.9869004228 121411.38287200584 136531.9553312917 134014.85234881504 170968.3284847566 171124.0040087329 145431.95509230215 152811.55817687893 145601.13133507728 0.972308091284305 0.970720389357116 0.8338629086102176 0.937712187256881 0.9204245263754283 1.1742239014015685 1.1752930931210892 0.9988380842839345 1.0495217775829504 1.0 17.151662039899 -6.741156467827324 24.967313096749873 1.0854851020368483 0.9248543727627644 0.5638083526616201 0.06698415788456062 180.5729091320708 222276.31953239636 0.023320101037872656 0.02329316970754112 1.8148616857211473e-07 6.741156467827324 -0.16063072927408395 TS(ph)FSVGSDDELGPIR ddPTM_A459_Selumetinib_30min_R1 1 TSFSVGSDDELGPIR 15 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 T(0.027)S(0.746)FS(0.222)VGS(0.005)DDELGPIR 143.58 0.00037681 5338000.0 801.74 1209.3 1182.6 1449.0 1090.4 987.86 983.5 1070.2 815.59 928.57 True False 820.4189820855274 1067.7145938116826 1022.0094155568133 1195.959351098708 991.7735125257557 977.9230253051151 909.3138031796074 1041.8148195004762 1383.9966616632425 1047.7610045377457 0.7830211074208495 1.0190440273951025 0.9754222681800478 1.1414428919564008 0.9465646347120059 0.9333455063414562 0.8678637582821486 0.994324865106148 1.3209087336418273 1.0 10.033093958703905 -8.030983498438369 21.984405772130213 1.159509070274742 0.9599328894595454 0.3419930850936883 0.1135046371692871 174.34095038293256 123700.58818388167 0.07418462053578172 0.028164743242306254 9.311432547474146e-09 8.030983498438369 -0.19957618081519657 TS(ph)FYLPK ddPTM_A459_Selumetinib_30min_R2 1 TSFYLPK 7 0 Q9NS23-3;Q9NS23-4;Q9NS23-2;Q9NS23-5;Q9NS23 Q9NS23-3 RASSF1 Ras association domain-containing protein 1 1 T(0.025)S(0.975)FYLPK 85.676 0.035905 1535000.0 31054.0 31675.0 27468.0 41819.0 31887.0 21729.0 27133.0 25272.0 21440.0 27418.0 True False 29328.142999011496 34104.3706488223 25700.73878489714 36123.18005820122 27881.069986603117 24721.972513777066 28394.738263019528 25345.537335995177 25728.59908365235 26626.371099480766 1.101469775563348 1.2808493700250188 0.9652362572757174 1.3566692931319375 1.0471224141823374 0.9284769757550312 1.0664141259404758 0.9518960447632848 0.9662825995899259 1.0 14.700568197000262 -6.510195291712175 24.183484529590096 0.9851732413645501 1.1726594769678345 0.44257915172489537 0.10254542400862172 356.9048037631121 680510.3067472887 0.03031143387276094 0.03272683996885151 3.0889061138832384e-07 6.510195291712175 0.18748623560328437 TS(ph)PAIESTPEGTPQPAGGR ddPTM_A459_Selumetinib_30min_R2 1 TSPAIESTPEGTPQPAGGR 19 0 Q8NFU5 Q8NFU5 IPMK Inositol polyphosphate multikinase 1 T(0.052)S(0.948)PAIESTPEGTPQPAGGR 123.92 0.0010494000000000002 0.0 9474.2 9543.7 9376.8 11326.0 12515.0 7605.7 8152.5 8015.9 9438.6 9946.4 True False 8947.661892227565 10275.671102167806 8773.506896687913 9783.379261560218 10942.753814480448 8653.316137329566 8531.607403872285 8039.224941896318 11326.583736518702 9659.221588149225 0.9263336398872283 1.0638197921429708 0.9083037195721876 1.012853796993675 1.132881538602031 0.8958606093006717 0.8832603461897598 0.8322849691904305 1.1726186870394548 1.0 13.237691215320863 TS(ph)PCQSPTISEGPVPSLPIRPSR ddPTM_A459_Selumetinib_30min_R2 1 TSPCQSPTISEGPVPSLPIRPSR 23 1 J3KQV8;O43426;A0A0D9SGJ6;C9JFZ1;O43426-2;J3KPK1;O43426-4 J3KQV8 SYNJ1 Synaptojanin-1 1 T(0.469)S(0.503)PCQS(0.008)PT(0.009)IS(0.01)EGPVPSLPIRPSR 55.049 0.010969 3964600.0 8277.0 7570.3 8027.9 8795.3 8892.6 6306.6 7713.9 7280.4 5710.1 6046.1 True False 7816.997475456249 8150.9176676489105 7511.393654116632 7597.364967261219 7775.432087147329 7175.276904385223 8072.611634802868 7301.584758664897 6852.279553524405 5871.533383345638 1.3313383344849643 1.3882093714682184 1.27928995097301 1.293932005702434 1.3242591976402658 1.222044811111455 1.3748728156260677 1.2435567137156267 1.1670340788592999 1.0 12.519521604975042 -8.515906113541604 1.4131293402784042 1.0011673393092941 1.3145759451603962 0.8187820799245176 0.04629515340452538 0.1749571209394083 0.7702602063806405 0.043870519904229036 0.013139661370832589 3.0485539595461517e-09 8.515906113541604 0.3134086058511021 TS(ph)PDTLR ddPTM_A459_Selumetinib_30min_R1 1 TSPDTLR 7 0 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 T(0.228)S(0.769)PDT(0.004)LR 127.46 0.0053382 353650000.0 8198.9 10398.0 7275.8 7692.0 7495.0 7306.6 9030.9 8441.4 4468.7 8823.1 True False 8389.918417717749 9180.597326100948 6287.786323108628 6348.736596722749 6817.078573349721 7233.102237862005 8349.691942180696 8217.506650468438 7583.057519065381 9955.630829271873 0.8427309691967921 0.9221512411958721 0.6315809044084952 0.637703095423746 0.6847460186355969 0.7265337939806887 0.8386903939457716 0.8254129538740081 0.7616852863576887 1.0 13.281297018531314 -9.29458625592148 0.6080226338875236 1.0093670040641995 0.7465611962497682 0.3887897148222005 0.08985104188127317 3.3521204534987197 1.721130748054023 0.18478974834997605 0.04158663758734109 5.074739388087575e-10 9.29458625592148 -0.2628058078144313 TS(ph)PDTLR ddPTM_A459_Selumetinib_30min_R2 2 TSPDTLR 7 0 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 T(0.212)S(0.726)PDT(0.062)LR;T(0.236)S(0.764)PDTLR 148.99 0.0026819 1317530000.0 1539540.0 1218380.0 1553200.0 1642290.0 1550050.0 1080410.0 1360320.0 1520630.0 1193690.0 1309290.0 True False 1453978.53006692 1311825.828290832 1453268.802996292 1418607.2688917296 1355318.8613771799 1229226.670514515 1423577.5754229417 1525054.7815461536 1432461.3544853071 1271487.3957560437 1.1435257124215255 1.0317253892326652 1.1429675259440213 1.1157069064363052 1.0659318101783375 0.9667627651028345 1.1196159554349834 1.199425795832868 1.126602874135096 1.0 20.278085729999162 -7.497755464270781 24.983741238284942 1.1297128050479197 1.076773780541151 0.030821372336377606 0.06804229168591584 1655.0674906717652 1645879.8136926237 0.028459865614953277 0.019089606066002424 3.17866335879824e-08 7.497755464270781 -0.052939024506768684 TS(ph)PHWK ddPTM_A459_Selumetinib_30min_R2 1 TSPHWK 6 0 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 T(0.37)S(0.63)PHWK 81.78399999999998 0.039755 18555000.0 102270.0 87375.0 86620.0 97682.0 98545.0 77445.0 101720.0 103500.0 95658.0 105770.0 True False 96586.24281924724 94076.38154509391 81046.96350472531 84377.54308915125 86164.89609652235 88112.34577428622 106450.18155435617 103801.16786465267 114792.2729078368 102716.14527653647 0.9403219188104649 0.9158869941216911 0.7890382109504545 0.8214632944215994 0.8388641908683957 0.8578237193098192 1.0363529634778132 1.0105633110081678 1.1175679597281274 1.0 16.648303441678927 -7.266321746751184 6.175316256021433 1.042858325899127 0.8567036023858083 0.7568979342952888 0.05010666726741923 0.07885493677836163 14.49255512594025 0.021662107227887722 0.01541913167763982 5.415994981399484e-08 7.266321746751184 -0.18615472351331874 TS(ph)PINEDIR ddPTM_A459_Selumetinib_30min_R2 2 TSPINEDIR 9 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 T(0.206)S(0.794)PINEDIR;T(0.225)S(0.775)PINEDIR 121.29 0.0063098 53138000.0 228624.0 187274.0 245163.0 237134.0 261662.0 201573.0 234157.0 252075.0 200538.0 197236.0 True False 215917.9933343853 201637.31361918032 229389.47949329132 204835.94012103317 228789.68027204025 229337.85105249117 245045.7644732933 252808.49651673742 240651.20349988187 191541.28419932816 1.1272660838469133 1.0527094169909903 1.1975981076464763 1.0694088273307694 1.1944666719157495 1.1973285655421932 1.279336543542673 1.3198642661999243 1.2563933906251108 1.0 17.54729585400446 -6.557736865181934 2.2021068900450183 1.2374293707207138 1.113346825936745 0.18621215857345264 0.08956895460678413 0.40299753025054436 3.951222252341429 0.031354450510438135 0.03300288425563463 2.76861861652046e-07 6.557736865181934 -0.12408254478396885 TS(ph)PITR ddPTM_A459_Selumetinib_30min_R2 3 TSPITR 6 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(0.155)S(0.845)PITR;T(0.222)S(0.778)PITR;T(0.225)S(0.775)PITR 109.01 0.025559 104028000.0 468550.0 346478.0 361880.0 411600.0 437340.0 377946.0 722520.0 1155790.0 535960.0 819920.0 True False 442509.86675426137 373051.74849763745 338597.0347851534 355539.36995039607 382397.4393307939 430004.63084780675 756118.6116462196 1159153.1575486644 643166.9759736162 796246.7791919991 0.5557446238003041 0.4685127252586141 0.4252413242145215 0.44651906826070165 0.48024990407978324 0.5400393974392701 0.9496033533893851 1.4557712355520342 0.8077482920888893 1.0 19.60285610613463 -7.309759923610688 3.391626830202469 1.1136248883637474 0.47468656624901384 0.7656067296756162 0.15473196230884287 0.10514253937576445 2.4636407775199753 0.06483771375939422 0.04311467401253049 4.9004964214308014e-08 7.309759923610688 -0.6389383221147336 TS(ph)PKPAVVETVTTAK ddPTM_A459_Selumetinib_30min_R2 1 TSPKPAVVETVTTAK 15 1 P56192;H0YI94;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 T(0.47)S(0.53)PKPAVVETVTTAK 97.083 0.005365699999999999 6027400.0 50750.0 32804.0 39789.0 49578.0 41395.0 29412.0 44804.0 36886.0 34550.0 34128.0 True False 47929.51816834657 35319.96131851513 37229.01905898762 42825.39087317964 36194.59002400467 33463.2360244471 46887.474777441756 36993.33215319397 41460.96540765805 33142.63596480706 1.4461589059856663 1.065695599952282 1.123296864453381 1.2921540374354756 1.092085435281562 1.0096733422163666 1.414717731783007 1.116185574149136 1.2509857529643664 1.0 15.016400729909705 -11.147805737208365 2.626774345630768 0.980122750006951 1.1925490690742329 0.15346952665870228 0.14045226641557973 26184646.530057725 24153139.86451677 3569557.3668880905 0.03392879953951337 7.115317153193339e-12 11.147805737208365 0.21242631906728182 TS(ph)PLNSSGSSQGR ddPTM_A459_Selumetinib_30min_R2 1 TSPLNSSGSSQGR 13 0 P51003;G3XAH6;H0YJL4 P51003 PAPOLA Poly(A) polymerase alpha 1 T(0.217)S(0.783)PLNSSGSSQGR 106.29 0.0092823 0.0 8708.1 8060.2 9053.5 11441.0 11596.0 8991.9 12663.0 10301.0 11713.0 9068.6 True False 8224.138663286281 8678.391422372137 8471.007666705491 9882.716063174152 10139.206810444695 10230.452604658843 13251.854591258481 10330.974204577653 14055.927288564353 8806.765954947521 0.9338432184252691 0.9854231924372573 0.9618749618237095 1.1221731239061914 1.1512974072790736 1.1616582814843075 1.5047356383774193 1.1730724147124465 1.5960373377094148 1.0 13.104396610579908 -6.368969465340904 1.0200067055914182 1.3276956008846958 0.9518622069982869 0.43607128252866245 0.1605561060001249 0.45477115148230496 1.0057891854346965 0.07127576923038646 0.09786965937414341 4.275929485780784e-07 6.368969465340904 -0.3758333938864089 TS(ph)PLVSQNNEQGSTLR ddPTM_A459_Selumetinib_30min_R1 1 TSPLVSQNNEQGSTLR 16 0 A0A1W2PNZ9;Q15652-3;Q15652;H7BXU7 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 T(0.418)S(0.582)PLVSQNNEQGSTLR 184.01 8.421200000000002e-07 16835000.0 2616.6 4277.2 2779.6 2670.0 2941.9 3013.4 3478.2 3582.5 1747.8 3541.0 True False 2677.561688982702 3776.4234355836647 2402.1455872498877 2203.73462210735 2675.8056644346293 2983.087931948285 3215.8365736851124 3487.4804623999794 2965.8889457386854 3995.5218422608505 0.6701406711538872 0.9451640072744015 0.6012094745277736 0.5515511387770002 0.6697011729813332 0.7466078399061676 0.804860216172775 0.8728473025757763 0.7423032742227355 1.0 11.964168225881785 -7.268576360064621 2.012300545487826 0.8559178669139262 0.6907405547210232 0.3337964929154168 0.11310284327063597 0.47050254051328294 3.720426187461228 0.06056601868681464 0.03838397927447801 5.3879510310102255e-08 7.268576360064621 -0.165177312192903 TS(ph)PPCS(ph)PANLSR ddPTM_A459_Selumetinib_30min_R2 1 TSPPCSPANLSR 12 0 P49585;C9JEJ2 P49585 PCYT1A Choline-phosphate cytidylyltransferase A 2 T(0.096)S(0.904)PPCS(1)PANLSR 154.23 0.008147399999999999 8498900.0 47362.0 42301.0 42797.0 41333.0 53522.0 39156.0 40078.0 34718.0 32855.0 41625.0 True False 44729.809645107984 45545.35068084708 40043.48761385043 35703.374096597996 46798.08786724912 44549.383577221924 41941.70641305042 34819.02363212568 39426.918045401006 40423.178095261734 1.1065386679814535 1.12671375252867 0.9906071096014144 0.883240155251005 1.1577043189668117 1.1020752369404585 1.0375657825371896 0.8613628436158771 0.9753542374250503 1.0 15.302895131302481 -7.611367916339114 7.884948413127452 0.9393809021106361 1.058240115344871 0.2910824099541779 0.08068930036810415 0.32292567242486564 25.069863996143237 0.0404571356012386 0.023238367231129185 2.4469893752377345e-08 7.611367916339114 0.11885921323423498 TS(ph)PPLLDR ddPTM_A459_Selumetinib_30min_R1 1 TSPPLLDR 8 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 T(0.224)S(0.776)PPLLDR 96.665 0.020894 6141900.0 3897.2 4362.3 3690.9 3895.4 3572.3 3919.2 3940.8 3550.7 2124.5 3452.5 True False 3987.9971773688676 3851.559888021749 3189.696052662472 3215.1415157142214 3249.1860957407916 3879.7764063488808 3643.5422832437202 3456.523901700935 3605.121332659253 3895.6620051978502 1.0237020491120168 0.9886791725983267 0.8187815186241949 0.8253132616290547 0.8340523616796098 0.995922233800629 0.9352819311280766 0.8872751016615434 0.9254194352202684 1.0 11.927652796636282 -6.765673584946622 24.997323585156327 0.9408908071349404 0.8946866173173076 0.10911113565343089 0.07028383504402612 318.0044971263876 1877377.1161860616 0.027014888565780933 0.024667784902310707 1.71524599936891e-07 6.765673584946622 -0.04620418981763286 TS(ph)PSGGTWSSVVSGVPR ddPTM_A459_Selumetinib_30min_R1 1 TSPSGGTWSSVVSGVPR 17 0 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4 Q99700 ATXN2 Ataxin-2 1 T(0.373)S(0.626)PSGGTWSSVVSGVPR 221.78 4.636e-12 29127000.0 2192.8 3074.1 2561.3 2597.8 2438.6 2354.8 2897.3 2474.4 1313.9 2245.4 True False 2243.8879735539504 2714.182942889683 2213.489528213822 2144.1429967454965 2218.0290605697987 2331.112849987331 2678.754328370389 2408.770874016052 2229.5923365408285 2533.6189620481528 0.885645397814679 1.071267220346174 0.8736473642526178 0.846276819388892 0.875439082906439 0.9200723885105764 1.057283817533837 0.9507234158323575 0.8800030193721189 1.0 11.30698385456365 -7.032549646526152 24.833560486371503 0.9708650316011004 0.9121765011069365 0.14751151169546062 0.07083028986422026 1349.1465355033404 1029319.1454366894 0.02849170476593124 0.022089893489177885 9.27791423262672e-08 7.032549646526152 -0.05868853049416389 TS(ph)PSSPAPLPHQEATPR ddPTM_A459_Selumetinib_30min_R2 2 TSPSSPAPLPHQEATPR 17 0 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 T(0.048)S(0.841)PS(0.106)S(0.005)PAPLPHQEATPR;T(0.227)S(0.752)PS(0.02)S(0.001)PAPLPHQEATPR 163.34 1.1393e-05 10877500.0 38012.0 27963.0 31411.0 34277.0 38791.0 29164.1 42354.0 33660.0 30877.0 29507.0 True False 35899.44521409241 30107.6721847835 29390.05045771094 29608.413468876908 33917.727784060015 33181.19004965925 44323.544922858855 33757.94502728702 37053.2627754633 28655.056241606933 1.2528136364976552 1.050693180670411 1.0256497216374958 1.0332701223557785 1.1836559488168696 1.1579523617015417 1.5467966473051757 1.1780798733268836 1.2930793945419738 1.0 14.80650210740002 -6.736484145572561 2.4827106493472324 1.272719712077692 1.0878070903350443 0.16916680005673146 0.14325270584281716 0.40119838691220283 5.0687161005850525 0.052571642452430366 0.04939606835024065 1.834492136173959e-07 6.736484145572561 -0.18491262174264778 TS(ph)PTVATQTGASATSTR ddPTM_A459_Selumetinib_30min_R2 1 TSPTVATQTGASATSTR 17 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.033)S(0.966)PTVATQTGASATSTR 157.37 4.1534e-05 78934000.0 60628.0 65150.0 67924.0 71840.0 68210.0 50329.0 58074.0 64008.0 45104.0 54908.0 True False 57258.53847311363 70146.79550973237 63553.843790059545 62055.26806908764 59640.849994863056 57261.36290882624 60774.55607144786 64194.2526829052 54126.060311056644 53322.66337188308 1.0738124251930359 1.3155156001963815 1.1918730192980447 1.1637691020101828 1.1184897044417241 1.0738653939596727 1.1397509469396487 1.2038830887947485 1.0150667068816595 1.0 15.702461221818886 -8.439137913486181 0.19968660497086574 0.9420321988471962 1.2408926299310354 0.35965653476101267 0.07223556607243987 4.164168066593736 0.6906799701452108 0.47402171661132225 0.3262791479935904 3.6379949051167173e-09 8.439137913486181 0.2988604310838392 TS(ph)PYILR ddPTM_A459_Selumetinib_30min_R1 2 TSPYILR 7 0 P49454 P49454 CENPF Centromere protein F 1 T(0.202)S(0.798)PYILR;T(0.225)S(0.775)PYILR 115.49 0.013004 3695700.0 6087.5 7499.4 6943.4 7061.7 6221.5 6271.9 6391.3 6234.8 3497.8 5537.2 True False 6229.326905786973 6621.366761623527 6000.524417366124 5828.506659526392 5658.766423495038 6208.810380429569 5909.199095334851 6069.432850515394 5935.511130795728 6247.953556895451 0.9970187596724498 1.0597656818873062 0.9603983708783725 0.9328665148437053 0.9056991816544209 0.993735040424127 0.9457815333491494 0.971427331404691 0.9499928379341263 1.0 12.6091680141526 -5.332528623275731 7.441629486058175 0.9543959107437315 1.028159957862876 0.4743128823966999 0.029733779166755934 0.1976540558583605 18.281579628416804 0.007596605491941449 0.015960879327635544 4.650197268559335e-06 5.332528623275731 0.07376404711914442 TS(ph)PYILR ddPTM_A459_Selumetinib_30min_R2 3 TSPYILR 7 0 P49454 P49454 CENPF Centromere protein F 1 T(0.18)S(0.82)PYILR;T(0.228)S(0.772)PYILR;T(0.157)S(0.843)PYILR 136.8 0.0028505 51233900.0 290249.0 269544.0 284807.0 321657.0 344282.0 231492.0 269953.0 280413.0 214612.0 314490.0 True False 274118.1225388063 290217.1580794368 266482.8276944151 277846.76171072584 301030.2172398692 263377.9217248507 282506.3494017213 281228.955405129 257540.39676029832 305409.8565568492 0.8975418332243045 0.9502547211517897 0.8725416746489707 0.9097504738161823 0.9856597970793887 0.8623753165472097 0.9250073084957406 0.920824751943724 0.8432615753262683 1.0 18.22038709772489 -6.026781398199575 24.969348076322806 0.9188638060464955 0.9077967665160795 0.01999333193453212 0.04810798699347281 5220.124592001083 4866931.082531891 0.013761495488863615 0.017813615875046374 9.401964386497044e-07 6.026781398199575 -0.01106703953041599 TS(ph)SEDNLYLAVLR ddPTM_A459_Selumetinib_30min_R2 3 TSSEDNLYLAVLR 13 0 Q15149-4 Q15149-4 PLEC Plectin 1 T(0.198)S(0.754)S(0.048)EDNLYLAVLR;T(0.023)S(0.718)S(0.259)EDNLYLAVLR;T(0.001)S(0.59)S(0.408)EDNLYLAVLR 211.13 6.2224e-06 45005300.0 90753.0 80861.0 83097.0 89832.0 99070.0 64755.0 71676.0 81664.0 62996.6 79152.0 True False 85709.31157304351 87062.77869090498 77750.6294891727 77596.72663115647 86623.94090296277 73674.41346263682 75009.07602329963 81901.62871979701 75597.68027207136 76866.67609840633 1.115038608711487 1.1326465916055142 1.0114998258755812 1.009497620683058 1.1269375144056573 0.9584701355931833 0.9758334798719726 1.0655024111481655 0.9834909496449362 1.0 16.23007066372776 -4.395339520931477 0.5781580167669036 1.0078547210732545 1.2799283889435296 0.39455874151124326 0.049013343735989215 6.079327524640349 1.1173535516428665 0.025471034494296534 1.2190886421387153 4.0240232291236486e-05 4.395339520931477 0.2720736678702751 TS(ph)SFTEQLDEGTPNR ddPTM_A459_Selumetinib_30min_R2 1 TSSFTEQLDEGTPNR 15 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71;C9J0Y3;C9JHJ5 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 T(0.007)S(0.474)S(0.26)FT(0.26)EQLDEGTPNR 249.36 5.5707e-28 28547000.0 26468.0 26608.0 33465.0 34407.0 37612.0 22323.0 27863.0 35679.0 24713.0 30022.0 True False 24997.014519798962 28648.748041795214 31311.898333937042 29720.707244614394 32886.84430445374 25397.790621981945 29158.684709487068 35782.8199830236 29656.290538913265 29155.18685347622 0.8573779562938567 0.9826295467003455 1.0739735091151945 1.0193969050509015 1.1279929183692605 0.8711242616836025 1.0001199737126854 1.2273226085929596 1.0171874626616326 1.0 14.831464948467938 -4.833238591999998 2.694367928362296 1.0447578818468186 0.8321117680708785 0.2902740445410754 0.08767816591910278 0.5282755932360639 5.623092036621058 0.023294056604753744 0.2427018501859768 1.4681195029340224e-05 4.833238591999998 -0.21264611377594012 TS(ph)SIADEGTYTLDSILR ddPTM_A459_Selumetinib_30min_R1 2 TSSIADEGTYTLDSILR 17 0 A0A087WY00;G3V394;F8WE88;F8W6H6;Q9Y4I1-2;Q9Y4I1;Q9Y4I1-3;E7ERV5 A0A087WY00 MYO5A Unconventional myosin-Va 1 T(0.001)S(0.499)S(0.499)IADEGTYTLDSILR;T(0.001)S(0.5)S(0.5)IADEGTYTLDSILR 251.28 1.2875e-30 72815070.0 2775.3 3567.09 2661.1 2776.5699999999997 3336.86 3415.52 3371.87 4457.87 2581.87 3925.8399999999997 True False 2839.9590902062546 3149.453444504848 2299.7372363759796 2291.6941721740086 3035.041602170482 3381.1629698440347 3117.5271311918887 4339.632806397487 4381.244817676131 4429.759804919892 0.6411090477303233 0.7109761213253418 0.5191561930337142 0.5173405044735719 0.6851481199498959 0.7632835907014104 0.7037688878140574 0.9796542019225724 0.9890479417891059 1.0 12.1130127582402 -7.5737091036818045 1.0629513928836143 1.0250249775378861 0.6097398533614896 0.8266872058781428 0.07207007942617882 0.21895241520833708 0.45504872665681106 0.06276215273272634 0.028116381304446703 2.668645560903472e-08 7.5737091036818045 -0.4152851241763965 TS(ph)SLDTLAAPYLAGHWPR ddPTM_A459_Selumetinib_30min_R2 1 TSSLDTLAAPYLAGHWPR 18 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.093)S(0.74)S(0.156)LDT(0.011)LAAPYLAGHWPR 114.9 0.00071079 11329000.0 12476.0 15059.0 17613.0 17254.0 14129.0 14952.0 17315.0 15777.0 13976.0 11746.0 True False 11782.633865385056 16213.976877683182 16479.798755584437 14903.975435189845 12353.98870513738 17011.502279257897 18120.181809021607 15822.908457977052 16771.590522067403 11406.862460226897 1.032942573513829 1.4214230191884567 1.4447266996552033 1.3065797441808888 1.083031267205412 1.4913393002302857 1.5885333826196737 1.3871394095570004 1.470307070024389 1.0 13.47761440206656 -6.812422197106328 24.999997358769374 1.4242269088513362 1.2799326763665333 0.08306330794387173 0.19042829436867206 233.75770877806895 114623.9199946608 0.06567763262727135 0.057922312335223165 1.5402024251954865e-07 6.812422197106328 -0.1442942324848029 TS(ph)STLDSEGTFNSYR ddPTM_A459_Selumetinib_30min_R2 1 TSSTLDSEGTFNSYR 15 0 Q92609;Q92609-2;C9JNM0;C9JED7;F2Z3C3;C9K0P2;C9J397;C9JWX0;C9JW04;C9JDR8 Q92609 TBC1D5 TBC1 domain family member 5 1 T(0.012)S(0.61)S(0.366)T(0.012)LDSEGTFNSYR 168.0 6.9032e-05 5071700.0 17404.0 18193.0 21572.0 17033.0 23228.0 22989.0 21285.0 22283.0 14992.0 21443.0 True False 16436.755353732085 19588.3446002849 20184.081005817723 14713.076016436098 20309.890979045296 26155.526076635884 22274.79467542736 22347.83984085078 17990.818911479277 20823.884874395153 0.7893222351580785 0.9406671578544185 0.969275479938706 0.7065480867370312 0.9753170986849885 1.2560348961973213 1.06967526999807 1.0731830287983135 0.8639511320772145 1.0 14.345951620434159 -6.518902925651062 24.999289211908494 1.064596853117046 0.8630779080793672 0.4086731266467848 0.11332210555782038 170.37954216738925 1071326.8732806118 0.0373775028865197 0.03820116726012147 3.0275900853105836e-07 6.518902925651062 -0.20151894503767875 TS(ph)TGSASSSAAVAASSK ddPTM_A459_Selumetinib_30min_R1 1 TSTGSASSSAAVAASSK 17 0 Q9UDT6-2;Q9UDT6 Q9UDT6-2 CLIP2 CAP-Gly domain-containing linker protein 2 1 T(0.178)S(0.756)T(0.058)GS(0.006)ASSSAAVAASSK 109.67 0.002212 5712800.0 1774.9 1844.4 2204.8 2384.0 1801.0 1393.1 1786.5 1759.5 1093.4 1713.6 True False 1816.2517166457988 1628.4567905617034 1905.4002700994945 1967.6791532224433 1638.0998679923764 1379.0866788335957 1651.7428666805974 1712.832344338525 1855.4199412236414 1933.5572518774898 0.9393317497489215 0.8422076920559074 0.9854377305090631 1.017647215416984 0.847194913107319 0.7132380887581676 0.8542508193521295 0.885845165782063 0.9595888300809419 1.0 10.917041767353762 -4.354730252689665 17.792108014329724 0.89415823650816 45.28464310852106 0.012307196524984132 0.08852306922718942 867131.299401782 5958212.621966074 0.023737430645455058 1677639538.2160478 4.4184479907651225e-05 4.354730252689665 44.3904848720129 TS(ph)VAGTVR ddPTM_A459_Selumetinib_30min_R2 1 TSVAGTVR 8 0 Q96EB6;B0QZ35;E9PC49 Q96EB6 SIRT1 NAD-dependent protein deacetylase sirtuin-1;SirtT1 75 kDa fragment 1 T(0.223)S(0.777)VAGTVR 99.013 0.018995 5687500.0 26067.0 32771.0 29608.0 29140.0 32430.0 27931.0 26453.0 30033.0 20889.0 34619.0 True False 24618.300494468764 35284.430324626854 27703.053514752966 25171.08173069616 28355.853472121547 31778.24171762657 27683.116915625098 30120.391057769182 25067.383687425998 33619.45951903584 0.7322634226326428 1.0495240205943313 0.8240184081206625 0.748705722542741 0.8434357326912422 0.945233569255724 0.8234254003979602 0.8959213351039914 0.7456212576300483 1.0 15.03700891092084 TS(ph)VQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R1 1 TSVQTEDDQLIAGQSAR 17 0 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 T(0.195)S(0.805)VQTEDDQLIAGQSAR 188.1 6.6604e-08 8277900.0 1975.2 1419.9 1562.8 1699.1 1897.0 1201.2 1488.0 1687.5 907.94 1855.9 True False 2021.2183169298455 1253.6574479063988 1350.5803438459225 1402.3840810571535 1725.4166849425528 1189.1170186023367 1375.7589620043268 1642.7420182274846 1540.70786668611 2094.1228429968696 0.965186127303453 0.5986551610851575 0.6449384516111414 0.6696761299113768 0.8239328894733479 0.5678353696293232 0.6569619192136301 0.7844535117512875 0.7357294591568586 1.0 11.032130359110468 -9.058979578597206 1.0924913891246664 1.0000828732823952 0.7002252771600831 0.3674878303041731 0.11180207689624709 2.2475369531431286 3.6117751264961173 0.10566822724193323 0.03251897568077068 8.730124182283198e-10 9.058979578597206 -0.2998575961223121 TS(ph)VQTEDDQLIAGQSAR ddPTM_A459_Selumetinib_30min_R2 1 TSVQTEDDQLIAGQSAR 17 0 G3XAM7;P35221-3;P35221;P35221-2;A0A0A0MTJ6;A0A0A0MRI5;P26232-4;P26232-3;P26232-2;P26232-5;P26232;P26232-6 G3XAM7;P26232-6 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 1 T(0.352)S(0.648)VQTEDDQLIAGQSAR 321.6 1.1328999999999997e-118 12955000.0 24502.0 21256.0 22077.0 26873.0 24598.0 21575.0 31227.0 26726.0 23978.0 18049.0 True False 23140.276929277377 22886.266851187578 20656.58985562016 23212.851041489295 21507.779331089892 24546.76041164987 32679.11737512662 26803.768235272513 28774.270001297376 17527.87847306618 1.3201983893735552 1.3057066139724351 1.178499148505716 1.3243388854594582 1.2270611850794915 1.400441043071419 1.8644080300614962 1.5292077861253957 1.6416287941243266 1.0 14.097363766313787 -7.005320944177776 21.90241105680357 1.5642707739623292 1.2751727610544314 0.20796886870471532 0.20802283469010507 55.572901638261975 228756.29503603288 0.0699213277968948 0.059660106479201336 9.878228225244572e-08 7.005320944177776 -0.2890980129078977 TSADAQEPASPVVSPQQS(ph)PPT(ph)SPHTWR ddPTM_A459_Selumetinib_30min_R2 1 TSADAQEPASPVVSPQQSPPTSPHTWR 27 0 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;F2Z3L2;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 2 TSADAQEPASPVVS(0.007)PQQS(0.985)PPT(0.53)S(0.452)PHT(0.026)WR 83.874 0.0002362 5584600.0 29965.0 23947.0 29895.0 33941.0 35542.0 25761.0 27275.0 26473.0 22403.0 31057.0 True False 28299.66525939912 25783.65789825879 27971.588247214953 29318.177248509226 31076.896210488543 29309.34391492527 28543.34154438718 26550.03204715894 26884.225992120475 30160.303714223275 0.9383083647812639 0.854887210107884 0.9274305893021844 0.9720783161305862 1.030390691849466 0.9717854366666506 0.9463877358412159 0.8802972376779559 0.8913778271881978 1.0 14.880363336166557 -5.515111910185399 10.285921413599452 0.9540680415664333 0.8952119470149285 0.20906076951403751 0.04635492327476898 0.3475969309217993 408.9273147942319 0.01365606915222309 0.025647501637822492 3.0541340142347163e-06 5.515111910185399 -0.05885609455150487 TSADAQEPASPVVSPQQS(ph)PPTS(ph)PHTWR ddPTM_A459_Selumetinib_30min_R2 2 TSADAQEPASPVVSPQQSPPTSPHTWR 27 0 E9PMG1;H0YDT0;Q96D71-4;Q96D71-2;F2Z3L2;Q96D71;Q96D71-3 E9PMG1;Q96D71 REPS1 RalBP1-associated Eps domain-containing protein 1 2 TSADAQEPASPVVSPQQS(0.962)PPT(0.331)S(0.646)PHT(0.061)WR;TSADAQEPASPVVS(0.005)PQQS(0.834)PPT(0.398)S(0.709)PHT(0.054)WR 105.72 8.7439e-06 0.0 31460.0 24878.0 30816.0 29648.0 29132.0 22014.0 24850.0 21439.0 18885.9 30117.0 True False 29711.579144358282 26786.062604621962 28833.33210992391 25609.891254347298 25472.177716615628 25046.22867680466 26005.574239340833 21501.38394058249 22663.607716135713 29247.443956636613 1.015869256418093 0.9158428560231113 0.9858410927352599 0.8756283555006553 0.8709197889012681 0.8563561559067919 0.8891571611487725 0.7351542915155688 0.7748919102037652 1.0 14.836022927246649 -5.910796250533736 0.8677348048708866 0.8313667097540509 0.9898182589660856 0.3343247386125814 0.07144882669294872 0.7737188856046902 1.1346120512540638 0.03210284696328973 0.08466500871001846 1.2280152199695973e-06 5.910796250533736 0.15845154921203464 TSASCSPAPES(ph)PMSSSESVK ddPTM_A459_Selumetinib_30min_R2 1 TSASCSPAPESPMSSSESVK 20 0 A0A2R8YDI1;A0A2R8Y852;P39880-6;P39880-4;P39880-5;P39880-2;P39880;P39880-3 A0A2R8YDI1 CUX1 Homeobox protein cut-like 1 1 TSASCSPAPES(0.999)PMS(0.001)SSESVK 147.6 2.1114e-05 7059800.0 24426.0 21356.0 29361.0 29570.0 30087.0 24847.0 25196.0 22911.0 19516.0 27682.0 True False 23068.50070502529 22993.936529636903 27471.945225839718 25542.514988904797 26307.202078807288 28269.44871139117 26367.66392492684 22977.66721687978 23419.745322600687 26882.748733526394 0.8581154008353236 0.8553417196121905 1.0219172711151563 0.9501452117896655 0.9785904834202716 1.0515832659677162 0.9808395780615554 0.8547365243280926 0.8711812008045562 1.0 14.714393039298633 -5.238890022410755 23.950312179050858 0.9622455575201484 0.856728494869936 0.35232146096097516 0.057949468099561245 577.0780448394717 612926.4453655803 0.016245605297163474 0.04289812096461589 5.769125380489071e-06 5.238890022410755 -0.10551706265021243 TSASEGNPYVSSTLSVPAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 5 TSASEGNPYVSSTLSVPASPR 21 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLSVPAS(1)PR 389.78 3.375599999999996e-295 393594000.0 6977.389999999999 8489.67 8644.189999999999 9765.57 8138.450000000001 7801.160000000001 8046.83 7788.23 4599.49 6401.879999999999 True False 7139.9496113624555 7495.695489659493 7470.356477136851 8060.196521952384 7402.328634460052 7722.687413286556 7439.851134559997 7581.660840663616 7804.998596541725 7223.623657591888 0.9884166105273918 1.0376641758989842 1.0341563779123033 1.1158106933604264 1.0247389655578676 1.0690877292825411 1.0299333806988766 1.0495647614055084 1.080482451260985 1.0 12.81850701670164 -4.691109236104 1.8667923401204585 1.053474398334598 0.9574542448690953 0.26549325014807645 0.03074496989944411 1.3830284674655848 4.186244632804651 0.007900519977809713 0.25220730793539653 2.0365297742633875e-05 4.691109236104 -0.09602015346550274 TSASEGNPYVSSTLSVPAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 TSASEGNPYVSSTLSVPASPR 21 0 E9PFQ4;Q86SQ0-2;Q86SQ0-3;Q86SQ0;G5E9V3;A0A1W2PQ63;E9PDY7 E9PFQ4 PHLDB2 Pleckstrin homology-like domain family B member 2 1 TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVS(0.001)S(0.006)T(0.006)LS(0.047)VPAS(0.939)PR;TSASEGNPYVSSTLSVPAS(1)PR;TSASEGNPYVSSTLS(0.001)VPAS(0.998)PR 354.95 6.682499999999993e-196 342219000.0 519639.3 453716.7 611088.9 607534.7 569027.1 440330.9 455808.6 439514.5 362026.44 531344.0 True False 490759.82798693323 488515.31196086784 571772.1054772871 524787.4258041853 497540.8285311822 500982.4845490687 477004.60306760634 440793.414429458 434441.8438638963 516002.7181224931 0.951079927975171 0.9467301136287811 1.108079638723056 1.0170245376102978 0.9642213326734292 0.9708911735425029 0.9244226557627763 0.854246303262338 0.8419371228210561 1.0 18.977019139720056 -7.17035960778015 1.686467128445254 0.8870968761666439 1.0032299409854775 0.35415950953527686 0.05878917437125602 0.3843513436999427 2.150374620533635 0.031552921946078366 0.020810843618035157 6.75523391793959e-08 7.17035960778015 0.11613306481883356 TSAVEQTFFLNTGES(ph)GNFTSRYK ddPTM_A459_Selumetinib_30min_R1 1 TSAVEQTFFLNTGESGNFTSRYK 23 1 A0A087WX88 A0A087WX88 PNLIPRP2 Triacylglycerol lipase 1 TSAVEQTFFLNT(0.018)GES(0.948)GNFT(0.014)S(0.014)RY(0.004)K 55.337 0.010703 5511900.0 2184.8 2308.1 2437.3 2670.4 2386.1 1946.0 2169.5 2067.4 1209.5 1742.0 True False 2235.701589119241 2037.8665789934214 2106.328047130578 2204.0647696162805 2170.2776763001707 1926.4250068266306 2005.8528683255295 2012.565836138371 2052.433161615139 1965.6026685169163 1.137412776716527 1.0367642513077322 1.0715940107671107 1.1213175505501771 1.1041283729725935 0.9800683717427765 1.0204772818297925 1.0238925029832653 1.044174997566389 1.0 10.940756006089734 -6.750665437986213 24.99999872126877 1.0156380764433655 1.0912959386539667 0.6428671509151831 0.029950412216516415 149.44886883607458 346782.62492784444 0.010172319044238008 0.010077794498265708 1.7755567676553678e-07 6.750665437986213 0.07565786221060122 TSAVS(ph)SPLLDQQR ddPTM_A459_Selumetinib_30min_R1 1 TSAVSSPLLDQQR 13 0 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 TSAVS(0.5)S(0.5)PLLDQQR 267.77 4.3204e-38 126960000.0 7516.7 7938.1 7944.8 7694.3 6988.0 6924.4 7408.0 6487.5 3659.3 6190.1 True False 7691.824485047876 7008.703561677428 6865.939797662581 6350.634944899095 6355.936633831607 6854.746822852164 6849.20859578498 6315.430425630107 6209.56483530242 6984.659631680005 1.101245427931866 1.0034423910777797 0.9830027746121012 0.9092261154852567 0.9099851630569473 0.9814002663438885 0.9806073533947645 0.9041858528059827 0.8890289810455441 1.0 12.76997409827081 -4.712816609057612 1.2775211289424873 0.9384379625555676 1.1901014381761017 0.6351537598985699 0.037084828442405335 1.0647443586556542 1.3576300671349197 0.011513965521815342 0.36828185856888324 1.9372398358135056e-05 4.712816609057612 0.25166347562053415 TSAVS(ph)SPLLDQQR ddPTM_A459_Selumetinib_30min_R2 1 TSAVSSPLLDQQR 13 0 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 TSAVS(0.5)S(0.5)PLLDQQR 209.22 8.706900000000001e-06 98483000.0 261720.0 249120.0 256630.0 310060.0 300200.0 221880.0 254710.0 261050.0 213170.0 236370.0 True False 247174.65014817083 268226.70295294776 240118.705197617 267829.2931166668 262486.1921779489 252441.9559738994 266554.5196982897 261809.6122808462 255809.95646745214 229545.38393698563 1.0768007873163101 1.1685127287359474 1.0460620077794025 1.1667814378275225 1.1435045552909315 1.0997474732194976 1.161227967761982 1.1405570776048264 1.1144199551304268 1.0 17.808419894776442 -8.580562283502971 16.878493857633988 0.9999999995353701 1.1265748826479174 0.48670876098645743 0.038389836426514265 392.4645860003556 114838.25015821776 0.03482551117146113 0.008991908318398717 2.6268647727241416e-09 8.580562283502971 0.12657488311254728 TSAVSS(ph)PLLDQQR ddPTM_A459_Selumetinib_30min_R1 3 TSAVSSPLLDQQR 13 0 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 T(0.156)S(0.004)AVS(0.412)S(0.428)PLLDQQR;TSAVS(0.026)S(0.974)PLLDQQR;T(0.01)S(0.001)AVS(0.024)S(0.965)PLLDQQR 206.46 1.228e-05 161777000.0 10409.099999999999 11724.699999999999 11299.599999999999 11894.7 10321.400000000001 9742.3 10554.0 9259.6 5476.9 8350.9 True False 10651.611777417194 10351.966673334853 9765.176384259898 9817.513936172398 9387.83119239117 9644.301307300655 9757.90328292585 9014.005328580284 9293.899283050814 9422.819359654372 1.130406025082486 1.098606083616418 1.0363327589692948 1.0418870999700989 0.9962868685127287 1.023504849153174 1.0355608985465863 0.9566144679771211 0.9863183117830366 1.0 13.201943071424292 -1.5228795839319735 0.36656653671127576 0.9868766634200041 2.997433320323494 0.8279389506804031 0.020477018477157646 25.491364229720695 0.35348851661839675 0.016955458563841355 35.976022272230864 0.02999994206805328 1.5228795839319735 2.01055665690349 TSAVSS(ph)PLLDQQR ddPTM_A459_Selumetinib_30min_R2 3 TSAVSSPLLDQQR 13 0 Q5T200;A0A087WX14;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 T(0.021)S(0.006)AVS(0.021)S(0.952)PLLDQQR;TSAVS(0.003)S(0.997)PLLDQQR;TSAVS(0.133)S(0.867)PLLDQQR 236.05 8.529700000000003e-15 243427000.0 512566.0 456789.0 521030.0 521011.0 578919.0 426178.0 441540.0 468275.0 406383.0 462348.0 True False 484079.63368427084 491823.2474918657 487507.49705457187 450048.40300589416 506190.01961847395 484880.15104130347 462072.48489491176 469637.6027229008 487670.9552897338 448998.8119156287 1.078131212906715 1.0953776144607796 1.0857656726855198 1.0023376255402268 1.127374964443318 1.079914107060972 1.029117388804449 1.0459662481493388 1.086129723170341 1.0 18.77635210192952 -14.522878734123909 0.15564370840667555 0.7480518428643108 1.088949238641787 0.2889046461004857 0.03356982532223178 178.8341961340516 1.6171720397341605 13.918277717803917 0.15570950272011602 3.000000077065881e-15 14.522878734123909 0.34089739577747613 TSCSGSGERES(ph)PER ddPTM_A459_Selumetinib_30min_R2 1 TSCSGSGERESPER 14 1 Q9H8Y5;C9JQZ3;C9K022 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 1 TSCSGSGERES(1)PER 178.03 0.00033729 2685300.0 4056.3 2352.8 3551.1 4490.1 4399.5 3040.3 2862.2 3513.5 3087.3 4146.5 True False 3830.8670846554505 2533.252194555613 3322.626092145343 3878.540634145467 3846.795477970974 3459.0737279044774 2995.2979713417053 3523.723703308762 3704.8462663693977 4026.779771099168 0.951347553732684 0.6291012517588279 0.825132309442983 0.9631866788400903 0.9553031694407601 0.8590173599089759 0.7438444964980281 0.875072366410272 0.9200518719597387 1.0 11.97541085656551 -14.52287873775725 0.13929570689780338 1.5039340778882473 0.8006065938197747 0.16778864873975463 0.09911369631021219 267.79922331919073 2.282069895072821 37.43715125468016 0.6555421669886976 3.000000051967652e-15 14.52287873775725 -0.7033274840684726 TSDDEVGS(ph)PKEESR ddPTM_A459_Selumetinib_30min_R1 2 TSDDEVGSPKEESR 14 1 Q6ULP2-7;Q6ULP2-8;Q6ULP2-6;Q6ULP2;Q6ULP2-9;B8ZZI9 Q6ULP2-7 AFTPH Aftiphilin 1 TSDDEVGS(0.999)PKEES(0.001)R;TSDDEVGS(1)PKEESR 244.0 2.8006999999999997e-19 30111300.0 4814.2 5279.7 6087.9 6316.1 4272.8 5267.6 4325.8 4349.3 3193.8 4386.3 True False 4926.361493197478 4661.550269534057 5261.196618440998 5213.111702880988 3886.3259944241113 5214.612726598127 3999.5014232784397 4233.942435482549 5419.645334077249 4949.324331180111 0.9953604095334853 0.9418558893315774 1.0630131036869277 1.0532976531845064 0.7852235445433944 1.0536009316962183 0.8080903888399659 0.855458675199209 1.0950273151294967 1.0 12.273015870341164 TSDDGGDS(ph)PEHDTDIPEVDLFQLQVNTLR ddPTM_A459_Selumetinib_30min_R1 2 TSDDGGDSPEHDTDIPEVDLFQLQVNTLR 29 0 Q9HAJ7 Q9HAJ7 SAP30L Histone deacetylase complex subunit SAP30L 1 T(0.014)S(0.014)DDGGDS(0.792)PEHDT(0.181)DIPEVDLFQLQVNTLR;T(0.014)S(0.014)DDGGDS(0.799)PEHDT(0.174)DIPEVDLFQLQVNTLR 96.351 1.1008e-07 5997900.0 1006.22 1392.9 845.3299999999999 931.9300000000001 1121.27 916.05 1035.25 1058.24 355.28999999999996 973.72 True False 1029.6629682367097 1229.818620458358 730.5388290653143 769.1859199926977 1019.8513264762965 906.8353687068517 957.1602590154439 1030.172037552032 602.9011806450956 1098.7064468359881 0.9371593032896939 1.1193332158921445 0.6649081118701828 0.7000831952954942 0.9282291274554951 0.8253663854602117 0.8711701490164516 0.9376226384387578 0.5487372740747147 1.0 10.101590262154453 -5.252577561405209 24.998897744736496 0.8103865036050192 1.028246261410408 0.2889781391841052 0.1372344867675783 794.1630624119954 2240295.8510460574 0.03399981800763844 0.08708220647934606 5.590136834313055e-06 5.252577561405209 0.2178597578053888 TSDIFGS(ph)PVTATSR ddPTM_A459_Selumetinib_30min_R1 6 TSDIFGSPVTATSR 14 0 A6NGP5;Q9H910;Q9H910-3;H3BMV3;H3BTV5;Q9H910-2;H3BU16;H3BMT0 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 TSDIFGS(0.995)PVT(0.005)ATSR;T(0.002)S(0.008)DIFGS(0.99)PVTATSR;TSDIFGS(1)PVTATSR;TSDIFGS(1)PVTATSR;TS(0.012)DIFGS(0.986)PVT(0.001)ATSR;TSDIFGS(0.998)PVT(0.002)ATSR 233.28 1.2699e-13 1100940000.0 17796.4 19905.2 21844.100000000002 22915.6 20637.6 16975.6 18430.2 17031.600000000002 10240.119999999999 15420.2 True False 18211.02149423365 17574.68993032358 18877.7912010524 18913.820639087324 18770.932723864204 16804.840876611568 17039.995175760847 16579.86664156637 17376.735731226465 17399.532875467597 1.0466385290096039 1.0100667676603516 1.0849596558807086 1.0870303688298892 1.0788181992132793 0.9658213813490066 0.9793363590689449 0.9528914804915876 0.99868978412212 1.0 14.086760954169854 -6.764254976173925 24.999579077994984 0.9764027929981199 1.0613665244080512 0.7341244926564028 0.024688672899284093 40.37138223334786 358452.839268236 0.00914714134139076 0.00842281286939112 1.7208579551762993e-07 6.764254976173925 0.0849637314099313 TSDIFGS(ph)PVTATSR ddPTM_A459_Selumetinib_30min_R2 3 TSDIFGSPVTATSR 14 0 A6NGP5;Q9H910;Q9H910-3;H3BMV3;H3BTV5;Q9H910-2;H3BU16;H3BMT0 A6NGP5;Q9H910-2 HN1L Hematological and neurological expressed 1-like protein 1 TSDIFGS(1)PVTATSR;TSDIFGS(0.999)PVT(0.001)ATSR;T(0.002)SDIFGS(0.998)PVTATSR 225.31 1.0095e-09 517299000.0 991450.0 978540.0 996640.0 1035340.0 1131460.0 883710.0 795610.0 841040.0 757620.0 873310.0 True False 936349.1780888129 1053590.8714979808 932517.267459587 894324.9059388821 989315.8794192604 1005433.0309793323 832607.4414713073 843487.2871583325 909165.1696714874 848095.2711681214 1.1040613123560226 1.2423024951510704 1.099543057438803 1.0545099546505978 1.166515028502198 1.1855189683990364 0.9817381015749777 0.994566667016735 1.0720082997506302 1.0 19.693866814132598 -7.265136610348861 24.999606830187023 1.0116254851466733 1.1418283184193756 0.5879968813513269 0.05330830525608048 245.5760875372146 1660501.7830633882 0.02257540158770516 0.015868964720470266 5.4307947519695806e-08 7.265136610348861 0.13020283327270232 TSDISEPS(ph)PESSILSSR ddPTM_A459_Selumetinib_30min_R1 1 TSDISEPSPESSILSSR 17 0 Q96JQ2 Q96JQ2 CLMN Calmin 1 TSDISEPS(1)PESSILSSR 187.0 3.5979000000000005e-14 0.0 415.06 701.78 783.12 391.34 590.87 497.37 629.13 534.78 508.67 537.97 True False 424.73009043383 619.6152713513289 676.7766053702445 322.999815361607 537.4259128265716 492.36690937582745 581.6742175845313 520.5958971897447 863.1758382131234 607.0236897715528 0.699692775736105 1.020743146918228 1.1149097090839115 0.5321041349855138 0.8853458635672462 0.8111164649292761 0.9582397316378848 0.8576203959777348 1.4219804807584542 1.0 9.245609010125584 -8.237400577646818 24.37395945418292 1.2109902091693938 0.8653924883800057 0.376570682770362 0.18055166009492477 503.7367502101634 510761.9246800188 0.1190338211727441 0.04493226816418716 5.788944985886017e-09 8.237400577646818 -0.3455977207893881 TSDPDVILCNS(ph)VELIR ddPTM_A459_Selumetinib_30min_R1 2 TSDPDVILCNSVELIR 16 0 Q96CW6;A0A087X0P9 Q96CW6 SLC7A6OS Probable RNA polymerase II nuclear localization protein SLC7A6OS 1 TSDPDVILCNS(1)VELIR;TSDPDVILCNS(1)VELIR 235.75 2.0499e-16 25172000.0 3462.6000000000004 4418.0 4675.5 4615.4 4336.9 3664.3 4339.3 3803.3 1896.6999999999998 3096.61 True False 3543.2718429532606 3900.7385061275236 4040.5927806831373 3809.4070317881133 3944.6281607418823 3627.4404689182015 4011.9831074095287 3702.4241291405006 3218.561370512967 3494.0900570356894 1.0140757064399468 1.1163817882349678 1.1564077384173346 1.0902429444019346 1.1289428996825628 1.0381645606454815 1.1482197201331463 1.0596247001949222 0.9211443660509212 1.0 11.770701077565993 -8.091628128170626 4.829840859078615 0.9635374821814032 1.1006040487886444 0.5832365151219184 0.04603740289734283 0.14918935437747427 5.678210303538512 0.031552205766190645 0.011429847774000022 8.097889976132212e-09 8.091628128170626 0.13706656660724115 TSDPDVILCNS(ph)VELIR ddPTM_A459_Selumetinib_30min_R2 1 TSDPDVILCNSVELIR 16 0 Q96CW6;A0A087X0P9 Q96CW6 SLC7A6OS Probable RNA polymerase II nuclear localization protein SLC7A6OS 1 TSDPDVILCNS(1)VELIR 87.85 0.030888 0.0 4212.7 4401.6 3670.0 3147.9 3758.3 1124.2 2397.7 3745.6 2386.0 3238.9 True False 3978.574998774256 4739.188566625294 3433.876195593873 2719.150589569612 3286.148754371704 1279.0483455284725 2509.197800952416 3756.4990758825397 2863.266670410189 3145.384541327168 1.264893035016803 1.5067119788875272 1.0917190411780235 0.8644890803787983 1.0447526244231944 0.4066429171769214 0.7977395984446727 1.194289291667186 0.9103073512283678 1.0 11.619020690304671 -5.500722974245074 3.3459230639410324 0.8801367047604483 1.3832152859563567 0.48994421457351234 0.20121861510096262 0.20401578034221948 4.695449150118837 0.058605334708270826 0.12515252988834452 3.157017765126203e-06 5.500722974245074 0.5030785811959084 TSDS(ph)TPDPQRVPLR ddPTM_A459_Selumetinib_30min_R1 1 TSDSTPDPQRVPLR 14 1 P52948-6;P52948-2;P52948-5;P52948;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 TS(0.052)DS(0.474)T(0.474)PDPQRVPLR 78.508 0.020874 10669000.0 3001.0 2952.9 4419.4 4735.8 3987.6 3524.3 3000.9 2985.1 1856.7 2908.6 True False 3070.9174610705063 2607.1730952340326 3819.269754026534 3908.781431976023 3626.922284067958 3488.84874180837 2774.539696961549 2905.925451028662 3150.684291997379 3281.9471421632047 0.9356998537905751 0.7943982588079059 1.163720678179225 1.1909946329603767 1.1051129487958093 1.0630423314827648 0.8453943883851791 0.8854272555752685 0.9600045812805786 1.0 11.6803362881837 -7.247078055334266 24.340916846839413 0.9131588268573415 1.0460514913728693 0.20727471785010676 0.11368170946981064 930.2471904396588 1576672.419501354 0.04871184702680943 0.03754283721148055 5.66137528534199e-08 7.247078055334266 0.13289266451552784 TSDS(ph)TPDPQRVPLR ddPTM_A459_Selumetinib_30min_R2 1 TSDSTPDPQRVPLR 14 1 P52948-6;P52948-2;P52948-5;P52948;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 T(0.017)S(0.017)DS(0.525)T(0.442)PDPQRVPLR 63.128 0.043682 10651000.0 42476.0 53882.0 52314.0 59916.0 61308.0 41625.0 36369.0 48280.0 31526.0 69537.0 True False 40115.35396490025 58014.57614206288 48948.17419517652 51755.33743913495 53605.94093952597 47358.46591587141 38060.23056380634 48420.48680681574 37832.08091003841 67529.28613117627 0.594043803261533 0.8591024645124935 0.7248436493182268 0.7664132172017889 0.7938176754215339 0.7013026292603945 0.5636107346059307 0.7170294487159021 0.56023220557299 1.0 16.043225686056374 -10.790022500752718 5.250517882594234 1.0000418855066566 0.7049208030353715 0.4781127352292497 0.09445084472661597 4.692888596230228e-05 6.5500686290290335e-06 0.09267405531279135 0.022473575551329172 1.6217260737201988e-11 10.790022500752718 -0.2951210824712851 TSDST(ph)PDPQRVPLR ddPTM_A459_Selumetinib_30min_R1 1 TSDSTPDPQRVPLR 14 1 P52948-6;P52948-2;P52948-5;P52948;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 TSDS(0.028)T(0.972)PDPQRVPLR 147.52 0.004943199999999999 7240300.0 1170.7 1263.0 1934.4 1784.2 1422.3 1320.3 1514.8 1126.6 660.16 1129.1 True False 1197.9750322143423 1115.1273728472302 1671.719104898613 1472.6229635819975 1293.6532161274606 1307.0189807364843 1400.537416427524 1096.718908287458 1120.2433038212896 1274.0309833653562 0.9403029030344993 0.8752749245560876 1.3121494898677917 1.1558768843219653 1.0154016919669193 1.0258926178419854 1.0992961982196074 0.8608259317135852 0.8792904713056224 1.0 10.315184647816753 -7.760110953184683 24.995448547372046 0.9025436328013274 1.0637376900631634 0.24662473062626267 0.1173730319944774 49.60854719879586 933488.7374677543 0.06262841789301223 0.03360897184227742 1.7373569135803395e-08 7.760110953184683 0.161194057261836 TSDVNETQPPQS(ph)E ddPTM_A459_Selumetinib_30min_R2 2 TSDVNETQPPQSE 13 0 P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35580 MYH10 Myosin-10 1 TSDVNETQPPQS(1)E;TSDVNETQPPQS(1)E 95.428 0.015005 12841300.0 20522.7 18372.199999999997 25947.0 27448.0 26090.0 15311.2 22975.0 20980.8 15199.2 21216.0 True False 19382.130492877357 19781.288664066058 24277.598268957572 23709.53504955899 22812.34095244068 17420.17881876494 24043.38302409882 21041.850654441587 18239.464701131008 20603.438954211975 0.9407230771499461 0.9600964532196289 1.1783274783841116 1.1507561966839537 1.1072103546955272 0.8454986013489617 1.1669597040344382 1.0212785691361483 0.8852631224168673 1.0 14.33059753968172 TSEIEPKNS(ph)PEDLGLSLTGDSCK ddPTM_A459_Selumetinib_30min_R1 1 TSEIEPKNSPEDLGLSLTGDSCK 23 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.004)S(0.004)EIEPKNS(0.991)PEDLGLSLTGDSCK 90.397 9.327e-05 13360000.0 4607.5 3992.1 13758.0 15596.0 7342.6 6716.5 4925.0 4509.3 3270.0 3290.6 True False 4714.845785365664 3524.703076123061 11889.73916728448 12872.451373178357 6678.463126441318 6648.938108094069 4553.503284859751 4389.698715729301 5548.951168649447 3712.9805631583044 1.2698277583643371 0.9492920892440405 3.2022088360115006 3.466878200468925 1.7986797972248312 1.790727959652556 1.2263741238080945 1.1822573916183854 1.494473529893581 1.0 11.85836204760359 -6.9635909519281975 2.212067110898212 1.243123975644859 2.2128355125764725 0.2589443621065445 0.7281756384765895 0.49524596359369133 4.895133006971221 0.3463232068717698 0.2791292438931639 1.0874493751818616e-07 6.9635909519281975 0.9697115369316134 TSES(ph)PSKPGEK ddPTM_A459_Selumetinib_30min_R1 1 TSESPSKPGEK 11 1 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;H0YA91;H0Y944;P20810-5;F8W7E0;E9PSG1;D6RGF7;D6RBR1;E7EN75 P20810-6;P20810-5 CAST Calpastatin 1 T(0.005)S(0.002)ES(0.961)PS(0.031)KPGEK 160.18 0.0028291 19791000.0 2987.9 3472.1 3575.8 2885.0 2470.5 3624.4 2495.2 3028.9 2370.2 2639.7 True False 3057.512256558669 3065.584917864502 3090.226000463429 2381.1889081571935 2247.043711202201 3587.9418266919015 2306.9850551029554 2948.56373274621 4022.0562874412612 2978.531207855399 1.0265167772944497 1.029227059894324 1.037499957131036 0.7994507164730016 0.7544133515458838 1.20460105209886 0.774537815490619 0.9899388413221408 1.3503488823060614 1.0 11.540385359802775 -8.02674020009677 22.9636707982735 1.1734979061554527 0.9453003360433608 0.2549183031442489 0.15415090619058483 357.30431168649477 306837.2354774241 0.10074306257498644 0.03842264923826225 9.40285631923897e-09 8.02674020009677 -0.22819757011209185 TSETDDGVVGKS(ph)SDGEDEQQVPK ddPTM_A459_Selumetinib_30min_R1 1 TSETDDGVVGKSSDGEDEQQVPK 23 1 Q16649 Q16649 NFIL3 Nuclear factor interleukin-3-regulated protein 1 T(0.009)S(0.009)ET(0.015)DDGVVGKS(0.554)S(0.413)DGEDEQQVPK 53.359 0.013891999999999998 6607400.0 621.6 665.04 907.14 940.72 956.63 713.6 740.43 700.26 420.27 606.84 True False 636.0820705769496 587.176807631292 783.9553705633409 776.4409115014327 870.1029854067447 706.4218318969596 684.5787689763872 681.6868300349499 713.1674946936704 684.7338251221619 0.9289479316484294 0.8575256341784124 1.144905278227605 1.1339310006525667 1.2707171071204368 1.031673631386515 0.9997735526710003 0.9955501028641774 1.041525142366723 1.0 9.419399471564585 -5.256316032304651 24.975001461381343 1.0816383165803773 0.893236768305886 0.43589261313528105 0.0836193616967684 409.1377264885993 1994423.97652133 0.023750568544376353 0.058896152896222326 5.542222634776164e-06 5.256316032304651 -0.1884015482744913 TSEVYS(ph)DDEEEEEDDKSSEK ddPTM_A459_Selumetinib_30min_R2 1 TSEVYSDDEEEEEDDKSSEK 20 1 Q92541 Q92541 RTF1 RNA polymerase-associated protein RTF1 homolog 1 T(0.019)S(0.006)EVY(0.05)S(0.925)DDEEEEEDDKSSEK 64.749 0.0097194 4821800.0 11603.0 12490.0 11011.0 10976.0 9358.3 5454.4 12055.0 9205.3 5557.2 10273.0 True False 10958.151710489166 13447.942838320132 10302.56424787034 9481.049865343903 8182.626689736508 6205.694089886586 12615.581386529331 9232.085898980553 6668.795281141456 9976.391797540511 1.0984083156387954 1.3479766143141516 1.0326944307069255 0.9503485887233574 0.8201990114054841 0.6220379287245396 1.264543498546184 0.9253932770820555 0.6684576364358024 1.0 13.284302409138943 -5.564150642502578 2.7846892161552392 0.889487156321076 1.2227464095655576 0.3508791871034881 0.17792092719180622 0.29252184461895725 4.566119203060944 0.0511521899327033 0.10796301292545323 2.7280313541300454e-06 5.564150642502578 0.3332592532444816 TSFS(ph)VGSDDELGPIR ddPTM_A459_Selumetinib_30min_R2 1 TSFSVGSDDELGPIR 15 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 TSFS(0.625)VGS(0.375)DDELGPIR 244.23 1.4402999999999998e-20 16907000.0 100980.0 90012.0 97594.0 111810.0 108130.0 79849.0 88828.0 95610.0 67631.0 88762.0 True False 95367.93585496818 96915.63096580243 91314.90829231298 96581.28511699157 94545.74270553507 90847.47495294693 92958.67800934278 95888.20927091237 81159.08976802681 86199.21042862759 1.106366698496992 1.1243215626209009 1.059347386574047 1.1204428049484314 1.096828407538818 1.053924676353829 1.0784168155033391 1.1124024082599597 0.9415293871540278 1.0 16.39538703406196 -8.258643363244945 24.999360151841923 0.97076468613008 1.0929811330775443 0.7791553123695117 0.026240601171956177 100.68186966585817 900222.7968405826 0.01943168706696685 0.006604690027779556 5.51260198005129e-09 8.258643363244945 0.12221644694746425 TSFSQEQSCDS(ph)AGEGSER ddPTM_A459_Selumetinib_30min_R1 4 TSFSQEQSCDSAGEGSER 18 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 TSFSQEQS(0.026)CDS(0.973)AGEGS(0.002)ER;TSFSQEQSCDS(1)AGEGSER;TSFSQEQS(0.001)CDS(0.999)AGEGSER;TSFSQEQS(0.002)CDS(0.998)AGEGSER 327.02 2.1833999999999993e-128 50619700.0 6715.899999999999 7702.900000000001 8125.9 8992.800000000001 7758.000000000001 8339.6 8020.4 7195.300000000001 4761.950000000001 6873.4 True False 6872.367403133428 6801.040887018947 7022.447412373672 7422.376295762913 7056.290269786149 8255.711195750957 7415.414770738917 7004.457270371689 8080.6813509328 7755.667842585628 0.8861090421379211 0.8769123465648031 0.9054600525584768 0.9570260674402993 0.9098236815971845 1.0644745705095362 0.9561284625962945 0.9031404403255754 1.041906579155254 1.0 12.921035302119696 -5.872672700133313 1.146645902216621 0.9812692297351824 0.8766521649421378 0.44021923201265034 0.04693672478539216 0.5255883069293312 1.381114650599752 0.017674032405212304 0.041343090600008736 1.3406866962715352e-06 5.872672700133313 -0.10461706479304456 TSFSQEQSCDS(ph)AGEGSER ddPTM_A459_Selumetinib_30min_R2 4 TSFSQEQSCDSAGEGSER 18 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 TSFSQEQS(0.001)CDS(0.999)AGEGSER;TSFSQEQSCDS(1)AGEGSER;TSFSQEQSCDS(0.786)AGEGS(0.214)ER;TSFSQEQS(0.006)CDS(0.994)AGEGSER 332.37 2.4451999999999986e-144 90244000.0 136643.0 127990.0 150039.0 142655.0 149885.0 102980.0 111135.0 108947.0 102223.0 124230.0 True False 129048.92908526844 137806.4214472854 140385.6540901114 123225.14290639856 131055.10631109898 117164.56024063523 116302.9977098246 109264.01773285316 122670.45634926285 120643.15711169639 1.069674668458731 1.1422647147711706 1.1636437362140366 1.02140184206479 1.08630368641433 0.9711662314354014 0.9640248190964242 0.9056793634113209 1.0168040963623781 1.0 16.88038656254753 -6.502489061944145 1.2740049855081115 0.961272079898862 1.1191002894118485 0.644984391012244 0.045944091658412 0.2559244643280893 0.8628495127112198 0.01968628886647333 0.022537924235706577 3.1442056086089025e-07 6.502489061944145 0.15782820951298648 TSFSVGS(ph)DDELGPIR ddPTM_A459_Selumetinib_30min_R1 5 TSFSVGSDDELGPIR 15 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 T(0.064)S(0.001)FS(0.033)VGS(0.903)DDELGPIR;T(0.045)S(0.011)FS(0.039)VGS(0.904)DDELGPIR;T(0.001)S(0.004)FS(0.237)VGS(0.758)DDELGPIR;TSFS(0.161)VGS(0.839)DDELGPIR;TSFS(0.129)VGS(0.87)DDELGPIR 300.71 1.3141999999999996e-80 274591000.0 6724.470000000001 6673.459999999999 6817.320000000001 7400.299999999999 6547.88 6076.99 6887.0 6152.67 3213.61 5686.59 True False 6881.137067459111 5892.128200792611 5891.565388858257 6107.9765258355865 5955.625410122107 6015.860998065449 6367.508045244491 5989.481204911227 5453.2614572120965 6416.519218577278 1.0724096403446683 0.9182748465450807 0.918187133578723 0.9519143195506389 0.9281707429285369 0.9375583229998233 0.9923617195455616 0.9334470919326979 0.8498784576883474 1.0 12.647575172676644 -4.756907769995311 24.998619164187556 0.935969284547098 1.0724098444962682 0.5145850655481439 0.039553659351150156 111.16705959636195 613177.4621504978 0.009640112545065315 0.07481219117594652 1.7502183385374522e-05 4.756907769995311 0.13644055994917015 TSFSVGS(ph)DDELGPIR ddPTM_A459_Selumetinib_30min_R2 3 TSFSVGSDDELGPIR 15 0 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 TSFSVGS(1)DDELGPIR;TSFS(0.001)VGS(0.999)DDELGPIR;T(0.007)S(0.001)FS(0.422)VGS(0.57)DDELGPIR 229.23 8.265700000000002e-14 33045300.0 84434.1 68731.8 89868.0 99192.0 102727.0 75692.0 79873.0 73959.0 64950.0 95384.0 True False 79741.59073848258 74003.30805243016 84085.99072088028 85681.87848425563 89821.51586896795 86117.88593643572 83587.252765347 74174.20844542849 77941.81485462777 92630.01608260529 0.8608612425088094 0.7989128274190921 0.9077618063446556 0.9249904308323399 0.9696804520563531 0.9296974088791887 0.9023776125743715 0.8007578059716806 0.8414315159474989 1.0 16.4991921436244 -5.276222400793348 23.559090260815548 0.9056283940568074 0.829887038991718 0.24450785322255641 0.05569189846026799 517.0060438955608 823932.4223831473 0.01570671370048626 0.032955825908114515 5.293922744011221e-06 5.276222400793348 -0.07574135506508939 TSFSVGS(ph)DDELGPIRK ddPTM_A459_Selumetinib_30min_R1 1 TSFSVGSDDELGPIRK 16 1 Q9NRY4 Q9NRY4 ARHGAP35 Rho GTPase-activating protein 35 1 TSFS(0.004)VGS(0.996)DDELGPIRK 144.4 0.0014844 0.0 1535.7 2038.6 1614.7 2062.3 1800.4 1311.0 1407.7 1355.6 788.1 1164.1 True False 1571.478822047975 1799.919764280571 1395.432608912215 1702.1580191655385 1637.554137886437 1297.8125302927608 1301.5160556542282 1319.6450843906248 1337.3481394534028 1313.5235742942264 1.1963841782530256 1.3702987898391483 1.0623582524295383 1.2958716938751027 1.246688045752294 0.988039008732746 0.9908585434818329 1.0046603732252675 1.0181379045077115 1.0 10.35922637794838 -6.7612843761236565 24.999834456495453 1.0000378721631735 1.2357406714132242 0.7169567320605092 0.07350448526194785 2.20199225931013 355164.6436693661 0.024215633361079087 0.02276667249837346 1.7326690741242105e-07 6.7612843761236565 0.23570279925005067 TSGAPGS(ph)PQTPPER ddPTM_A459_Selumetinib_30min_R1 3 TSGAPGSPQTPPER 14 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7;K7EIM4 Q96MH2 HEXIM2 Protein HEXIM2 1 TSGAPGS(0.847)PQT(0.153)PPER;TSGAPGS(0.966)PQT(0.034)PPER;T(0.019)S(0.01)GAPGS(0.898)PQT(0.073)PPER 182.7 7.6255e-05 96644000.0 15270.5 17589.07 15771.95 17843.65 16097.02 15469.71 17290.05 15510.119999999999 8693.070000000002 14372.14 True False 15626.272938779466 15529.733507463203 13630.205819119969 14727.59149429431 14641.047383159712 15314.098762772857 15985.847608200878 15098.74123362992 14751.5048732879 16216.944165498688 0.9635769093923462 0.9576239116924682 0.8404916290035722 0.9081607079604459 0.9028240606703405 0.9443270326695321 0.9857496853328592 0.9310472478379911 0.909635300136971 1.0 13.985214370952676 -6.8601315724145495 5.5605096739645985 0.9526422948989903 0.912572393731831 0.20167224343936485 0.03951432938203503 0.38620028163419445 18.03316541707554 0.014771276605870529 0.013056237508788529 1.379966131309752e-07 6.8601315724145495 -0.04006990116715936 TSGAPGS(ph)PQTPPER ddPTM_A459_Selumetinib_30min_R2 4 TSGAPGSPQTPPER 14 0 Q96MH2;K7ESM2;K7ELS4;K7EJA3;K7ERG7;K7EIM4 Q96MH2 HEXIM2 Protein HEXIM2 1 T(0.023)S(0.002)GAPGS(0.949)PQT(0.025)PPER;T(0.007)S(0.004)GAPGS(0.828)PQT(0.161)PPER;TSGAPGS(0.915)PQT(0.085)PPER;TSGAPGS(0.5)PQT(0.5)PPER 142.54 0.00054529 109229800.0 54954.4 41612.899999999994 54432.0 52347.6 51932.799999999996 40001.5 42194.2 45027.600000000006 35578.1 49405.8 True False 51900.254447893305 44804.47562343729 50929.904381080545 45217.76657535315 45408.53737887736 45511.34352753711 44156.31390622112 45158.62286127956 42694.71413517219 47979.32618231552 1.081721203225713 0.9338287797787282 1.0614968661200699 0.9424427180059014 0.9464188222721286 0.9485615399140792 0.9203195922017032 0.9412100263701572 0.889856476369375 1.0 15.550125276233361 -5.833431496544088 9.363366958300135 0.9382692375743921 1.016389916588151 0.4253843073793113 0.04448578686848267 0.30209778338552884 36.49231315308018 0.011664245423086314 0.017343484915446343 1.4674675396989587e-06 5.833431496544088 0.07812067901375885 TSGGDHAPDS(ph)PSGENSPAPQGR ddPTM_A459_Selumetinib_30min_R1 5 TSGGDHAPDSPSGENSPAPQGR 22 0 E9PL60;E9PII7;H0YDE3;H0YDU2;E9PRI1;Q96NY9 E9PL60 MUS81 Crossover junction endonuclease MUS81 1 TSGGDHAPDS(0.985)PS(0.015)GENSPAPQGR;TSGGDHAPDS(0.986)PS(0.014)GENSPAPQGR;TSGGDHAPDS(0.769)PS(0.231)GENSPAPQGR;TSGGDHAPDS(0.978)PS(0.022)GENSPAPQGR;TSGGDHAPDS(0.721)PS(0.277)GENS(0.001)PAPQGR 252.58 1.078e-44 29988900.0 6935.74 8584.66 8266.11 9729.33 8710.19 7533.21 8589.49 7431.84 3117.1400000000003 5822.16 True False 7097.329247399249 7579.564016299843 7143.6176644920715 8030.285157643338 7922.3548524089465 7457.432747007421 7941.577853861928 7234.723461181478 5289.558913102122 6569.490948640902 1.080346910116003 1.1537521058413065 1.0873928772167567 1.222360335134436 1.2059313140613923 1.1351614311227898 1.2088574161906538 1.1012608918622835 0.805170287082354 1.0 12.681565869163403 -8.111786456866145 5.3178422724540155 0.9067684524347812 1.157039637822386 0.7138748921184224 0.06320966474639136 0.11177890147496804 4.419564875209049 0.042803785559515084 0.01559880924341312 7.73060606515832e-09 8.111786456866145 0.25027118538760473 TSGGDHAPDS(ph)PSGENSPAPQGR ddPTM_A459_Selumetinib_30min_R2 2 TSGGDHAPDSPSGENSPAPQGR 22 0 E9PL60;E9PII7;H0YDE3;H0YDU2;E9PRI1;Q96NY9 E9PL60 MUS81 Crossover junction endonuclease MUS81 1 TSGGDHAPDS(0.542)PS(0.442)GENS(0.016)PAPQGR;TSGGDHAPDS(0.983)PS(0.017)GENSPAPQGR 176.86 3.1129e-16 28414000.0 48139.6 42064.2 60163.0 61400.0 87183.0 52777.9 46386.1 63706.1 57920.7 64173.0 True False 45464.193750087434 45290.38888227912 56292.178080521604 53037.21407909213 76230.29211409097 60047.57665492548 48543.145562313395 63891.47420388742 69506.45843957577 62320.15874852212 0.7295262827161137 0.7267373798747448 0.9032739840679006 0.8510442711340153 1.2232043955744694 0.9635337563441214 0.7789316737493799 1.025213598407314 1.1153126024606617 1.0 15.927411287939627 -5.526428163424078 1.6102557975314138 1.0005014886178982 0.7166578625237305 0.46828996230848463 0.11451839713745189 0.4013439237640442 1.9845855888237176 0.03704915866746787 0.11216686537986618 2.975581408588077e-06 5.526428163424078 -0.2838436260941677 TSGLPANPS(ph)PGPAPQATSVK ddPTM_A459_Selumetinib_30min_R2 1 TSGLPANPSPGPAPQATSVK 20 0 A0A590UJ53;Q9P2N6-6;Q9P2N6-5;Q9P2N6-4;Q9P2N6-3;Q9P2N6 A0A590UJ53 KANSL3 KAT8 regulatory NSL complex subunit 3 1 TSGLPANPS(0.999)PGPAPQAT(0.001)SVK 147.75 4.1534e-06 0.0 8717.6 9727.0 10931.0 12985.0 10739.0 6096.8 8138.4 9723.5 8544.1 8090.9 True False 8233.110691317797 10473.02962276541 10227.71136077292 11216.420599625595 9389.870812121899 6936.578858759997 8516.85172593366 9751.793775187924 10253.158742100464 7857.294694317193 1.047830202585174 1.3329052848609655 1.3016835639587423 1.4275168535727567 1.1950513729506855 0.8828202490326467 1.0839420000491382 1.2411134053863262 1.3049222589953366 1.0 12.939816955553745 -6.522017051696507 24.998799223629423 1.1078511571114154 1.2866853120558102 0.25418239443802515 0.14095559419127915 47.246542487080816 1370741.9815810006 0.04848778980923923 0.049066638988701824 3.005958277424936e-07 6.522017051696507 0.1788341549443948 TSGPLS(ph)PPTGPPGPAPAGPAVR ddPTM_A459_Selumetinib_30min_R2 2 TSGPLSPPTGPPGPAPAGPAVR 22 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4;A0A2R8YHA2 P49815 TSC2 Tuberin 1 TSGPLS(0.999)PPTGPPGPAPAGPAVR;T(0.164)S(0.108)GPLS(0.728)PPTGPPGPAPAGPAVR 190.37 9.5687e-22 6838800.0 15700.0 14091.5 18062.4 18641.3 20727.8 16803.4 18542.9 17727.7 13263.7 15399.7 True False 14827.456852079624 15172.272738686015 16900.284848854157 16102.322781963856 18123.788455116897 19117.91582392202 19405.181592059285 17779.28467202127 15916.81061874252 14955.070647774239 0.9914668543733287 1.0145236419156671 1.13007054576298 1.0767132540667979 1.2118825033978866 1.2783567710372092 1.2975653575362651 1.1888465852662058 1.0643086210436201 1.0 13.868347105316163 -5.490465931447609 1.2094476392982874 1.1892745523251258 0.9822110789054322 0.315452770665375 0.08934967599731307 0.664666603768736 1.6826926348622986 0.030811079987174146 0.1264531438574055 3.2324667667008447e-06 5.490465931447609 -0.20706347341969356 TSGVPGNRPGS(ph)VIR ddPTM_A459_Selumetinib_30min_R1 2 TSGVPGNRPGSVIR 14 1 A0A087X2D8;O60271-4;O60271-2;O60271-9;O60271 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 TSGVPGNRPGS(1)VIR;TSGVPGNRPGS(1)VIR 107.13 0.025174 50078000.0 7933.400000000001 7201.9 7596.5 8965.0 7061.799999999999 7729.3 7285.200000000001 6776.200000000001 4085.6000000000004 5730.0 True False 8118.232784290823 6358.698199927527 6564.937024587628 7399.43104389228 6423.061436862052 7651.5502596428905 6735.671498651832 6596.473163800344 6932.964799582319 6465.501314926482 1.2556230969358535 0.9834810775225756 1.0153794276449353 1.1444481538979345 0.9934359493568654 1.1834426886555964 1.0417864246816602 1.0202570291914559 1.0723011970590175 1.0 12.658546521135136 -6.804054292565019 0.011139790005988782 3.4697025638899895e-07 2.1392147228955043 0.12664686044223827 0.08219861860583463 4888.879733565715 22.018677312662156 2051.3258346000835 2174.5552466204867 1.570166500444881e-07 6.804054292565019 2.1392143759252478 TSGVPGNRPGS(ph)VIR ddPTM_A459_Selumetinib_30min_R2 1 TSGVPGNRPGSVIR 14 1 A0A087X2D8;O60271-4;O60271-2;O60271-9;O60271 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 TSGVPGNRPGS(1)VIR 63.145 0.043647000000000005 20711000.0 29870.0 22674.0 26418.0 32283.0 26246.0 23156.0 29045.0 30064.0 20970.0 25541.0 True False 28209.944979083983 24413.02289159896 24718.294641743592 27885.999708718755 22948.742837782982 26345.52881076083 30395.65005157564 30151.481262636855 25164.585950755114 24803.56496651243 1.1373342911460729 0.9842545990690957 0.9965621746356235 1.1242738592765982 0.9252195347227843 1.0621670250357247 1.225454892980632 1.215610792373786 1.0145552054605902 1.0 14.598259870721387 -7.013836387716321 24.80897235497397 1.133578250966335 1.029770529779854 0.13516834995495997 0.09043590940704856 896.361612138261 1607196.1386772871 0.032739816099918745 0.026470764390761774 9.686427054659552e-08 7.013836387716321 -0.10380772118648096 TSIDAYDNFDNISLAQR ddPTM_A459_Selumetinib_30min_R2 1 TSIDAYDNFDNISLAQR 17 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 203.32 3.852e-07 2291500.0 5456.5 6481.4 6215.1 5705.4 7410.5 6503.9 4213.9 6087.9 3188.1 7038.0 False True 5153.2495741001585 6978.502539014259 5815.227232489232 4928.314677636034 6479.526739289447 7399.753188474145 4409.854699684439 6105.614781093903 3825.8090829567163 6834.794653079936 0.7539728456623009 1.0210259259024796 0.850826912534781 0.7210625816556474 0.9480206894540135 1.0826591820340385 0.6452066116861673 0.8933135655132747 0.5597547954469572 1.0 12.738682278318798 -7.281880627252822 24.976547415816015 0.7656782329563888 0.8942564159757781 0.13069770021398264 0.15301430993407297 1663.614737056347 2032712.4823261641 0.06175580301376325 0.041692471477318076 5.2253979763768427e-08 7.281880627252822 0.12857818301938928 TSIS(ph)DPPESPPLLPPR ddPTM_A459_Selumetinib_30min_R2 1 TSISDPPESPPLLPPR 16 0 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 T(0.006)S(0.027)IS(0.649)DPPES(0.318)PPLLPPR 84.75299999999999 0.016843 2812100.0 24696.0 17392.0 21570.0 20795.0 26225.0 20438.0 25770.0 28240.0 21326.0 23145.0 True False 23323.49518592093 18725.910475905825 20182.209683640292 17962.68512662413 22930.381045525344 23253.148982308234 26968.356062286268 28322.173724616325 25591.795898226195 22476.743712068073 1.0376723374479828 0.8331238152549484 0.8979151936854708 0.7991675910323129 1.0201825201758965 1.034542604577695 1.1998337663033718 1.2600656966787303 1.1385900122394335 1.0 14.456145421748387 -6.795581684753147 1.872288887828214 1.1673962784325425 0.8914781135502925 0.5999604788335091 0.09022840351246612 0.20655767951672357 1.4933063371585116 0.036524453642122076 0.03262845233608171 1.6010994754741052e-07 6.795581684753147 -0.27591816488224996 TSISDPPES(ph)PPLLPPREPVR ddPTM_A459_Selumetinib_30min_R1 2 TSISDPPESPPLLPPREPVR 20 1 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 TSIS(0.001)DPPES(0.999)PPLLPPREPVR;T(0.001)S(0.002)IS(0.035)DPPES(0.961)PPLLPPREPVR 107.25 0.0002489 47566000.0 6150.3 6821.7 7679.299999999999 8896.0 7304.1 6667.2 7230.0 6656.0 3716.8999999999996 5149.2 True False 6293.590023599442 6023.012192677712 6636.493239375472 7342.480598601863 6643.445444643591 6600.134021333249 6684.635279093608 6479.461258264974 6307.307828364872 5810.1499774553995 1.0832061217042404 1.036636268607224 1.1422240845978946 1.2637334022516162 1.143420646699578 1.1359662051656416 1.150509936065574 1.1151969025595971 1.0855671287038284 1.0 12.504359689073048 -10.264208671973883 9.48560517173966 0.999999999987276 1.1310902804415504 0.31751657092468144 0.05640080209647092 0.0 0.0 0.05988147579001156 0.014523391158828497 5.442410903415851e-11 10.264208671973883 0.1310902804542744 TSISDPPES(ph)PPLLPPREPVR ddPTM_A459_Selumetinib_30min_R2 3 TSISDPPESPPLLPPREPVR 20 1 G5E9C8;Q07889 G5E9C8 SOS1 Son of sevenless homolog 1 1 TSISDPPES(1)PPLLPPREPVR;T(0.001)S(0.001)IS(0.003)DPPES(0.995)PPLLPPREPVR;T(0.006)S(0.006)IS(0.006)DPPES(0.981)PPLLPPREPVR 89.87700000000002 0.00097418 31183000.0 167936.0 126692.0 169923.0 177486.0 187443.0 126718.0 133555.0 135644.0 106947.0 162032.0 True False 158602.7894210727 136408.8690210131 158990.3391781738 153312.1006195728 163894.73457831892 144172.2542685262 139765.5721342118 136038.70158292702 128339.38834885127 157353.715150305 1.0079380030498457 0.8668932213689057 1.0104009239712293 0.9743150994123548 1.041568890964957 0.9162303802665998 0.8882254352921193 0.8645407669782834 0.8156107927052175 1.0 17.263651715771893 -6.988625954701356 23.190448863205678 0.8838662386647778 0.9756378906908109 0.3205396872654427 0.06079814824285018 105.44889536280837 214996.23475428871 0.021068715782612615 0.018559197203277197 1.0265356711610057e-07 6.988625954701356 0.0917716520260331 TSKEPPSS(ph)PLQPQK ddPTM_A459_Selumetinib_30min_R1 2 TSKEPPSSPLQPQK 14 1 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 T(0.003)S(0.001)KEPPS(0.008)S(0.988)PLQPQK;TSKEPPS(0.078)S(0.922)PLQPQK 117.13 0.0014021 68316000.0 11325.2 11951.5 16572.2 18071.0 13627.400000000001 12945.3 14262.2 13205.4 8048.2 9508.3 True False 11589.0551249969 10552.212823898393 14321.786264578577 14915.239084682371 12394.804076112887 12815.08203539197 13186.39077143691 12855.149894815539 13657.207582729196 10728.782923685076 1.0801835778979803 0.9835423923624288 1.3348938427080592 1.3902079285950684 1.1552851953738266 1.1944581343985567 1.229066788398372 1.1981927480736192 1.2729503131785127 1.0 13.389198805172928 -11.860081715883453 2.034954099006984 0.000124179053934358 1.2059408870973065 0.23292297248593585 0.11119450592023253 4966571.138793329 541372.6888706983 22853624.536970563 0.03141472228438286 1.3801245590044543e-12 11.860081715883453 1.2058167080433722 TSKEPPSS(ph)PLQPQK ddPTM_A459_Selumetinib_30min_R2 3 TSKEPPSSPLQPQK 14 1 Q92615;H0Y4V9;A0A087X183 Q92615 LARP4B La-related protein 4B 1 TSKEPPS(0.014)S(0.986)PLQPQK;TSKEPPS(0.004)S(0.996)PLQPQK;TSKEPPS(0.017)S(0.983)PLQPQK 211.45 1.9679e-06 70551000.0 412007.0 464181.0 449306.0 480645.0 455242.0 311129.0 311068.0 304523.0 232558.0 478977.0 True False 389109.3003346985 499782.19012284186 420398.1411273847 415180.3218411281 398050.43004488305 353984.1956021418 325533.2783695481 305409.11151350336 279076.0982134343 465147.68947829923 0.836528502960245 1.074459147982414 0.9037949680001532 0.8925774140827969 0.8557506337209345 0.7610146274168613 0.6998492860077624 0.6565852489905827 0.5999730935489344 1.0 18.82732933484713 -6.5690030285925225 1.4001172712999013 0.7098871874848275 0.9464478380480755 0.35747140878793293 0.11431226830314495 0.3788637148510839 1.5370232458229514 0.04669703597391768 0.04989854562822688 2.697720619576406e-07 6.5690030285925225 0.23656065056324804 TSLAGDTSNS(ph)SSPASTGAK ddPTM_A459_Selumetinib_30min_R2 1 TSLAGDTSNSSSPASTGAK 19 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 TSLAGDTS(0.001)NS(0.63)S(0.184)S(0.184)PAS(0.001)TGAK 329.64 1.4617999999999992e-154 4457100.0 25091.0 25925.0 26595.0 30367.0 28556.0 21839.0 22573.0 23082.0 18499.0 25842.0 True False 23696.542667231202 27913.36413798637 24883.906654446615 26230.96221400312 24968.539986120948 24847.12401529648 23622.68922755095 23149.164798569196 22199.316905246487 25095.87431442052 0.9442405699973866 1.1122690442367602 0.9915536849874921 1.0452300599437718 0.9949260851921624 0.9900880002821378 0.9412977181662465 0.9224291016339403 0.884580334883586 1.0 14.615162588532147 -7.03723593113324 1.509930001078292 0.9271486454995859 1.0262119372891987 0.37980035218572106 0.04837573159854785 0.3634755813022088 1.6696486081275306 0.023377969062055942 0.01683222003821274 9.178338463991526e-08 7.03723593113324 0.09906329178961282 TSLAGDTSNSS(ph)SPASTGAK ddPTM_A459_Selumetinib_30min_R1 1 TSLAGDTSNSSSPASTGAK 19 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 TSLAGDTSNS(0.006)S(0.911)S(0.083)PAS(0.001)TGAK 241.64 6.336699999999999e-30 6182500.0 3534.7 4144.2 4867.4 4894.3 4012.0 2981.5 3988.3 3480.0 2046.4 3484.5 True False 3617.0516326710804 3658.9951374136867 4206.433814714383 4039.602382389512 3649.1153083761324 2951.508816985405 3687.459320001249 3387.6990953669024 3472.5913368575643 3931.769516904245 0.919955154319177 0.9306229985461273 1.0698576802707398 1.0274260393498782 0.9281101785562786 0.7506820540460705 0.93786253343371 0.8616219950843591 0.8832133526463108 1.0 11.940963037020833 -6.520420101145142 24.997588517149204 0.8765786994521864 0.9874751668523439 0.2987733778938567 0.07161025384227554 112.57535934505049 1144596.0624710654 0.023379271823009074 0.023772250453587315 3.017031877265039e-07 6.520420101145142 0.11089646740015757 TSLAGDTSNSS(ph)SPASTGAK ddPTM_A459_Selumetinib_30min_R2 1 TSLAGDTSNSSSPASTGAK 19 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 TSLAGDT(0.001)S(0.005)NS(0.158)S(0.56)S(0.275)PAS(0.001)TGAK 137.91 0.0001543 8270000.0 27193.0 25774.0 29602.0 33322.0 35528.0 29452.0 29932.0 27299.0 24361.0 32957.0 True False 25681.72192220389 27750.7829235279 27697.439548220656 28783.486116343796 31064.655015650143 33508.74566136327 31323.897309132815 27378.435570407255 29233.880703211507 32005.445777430443 0.8024172542634633 0.8670644088668548 0.8653977120278793 0.8993308925145888 0.9706052911019373 1.046970127970938 0.9787052343205218 0.8554305339410064 0.9134033284993835 1.0 14.966029782401106 -5.893615350495084 2.0884307897360115 0.958196291778802 0.8410579009144494 0.5183824646825332 0.05041697551212501 0.304554519361594 2.7021347014020556 0.01770482922546713 0.030459380438175303 1.2775698364177887e-06 5.893615350495084 -0.11713839086435252 TSLAGDTSNSSS(ph)PASTGAK ddPTM_A459_Selumetinib_30min_R1 1 TSLAGDTSNSSSPASTGAK 19 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 TSLAGDTSNSS(0.002)S(0.99)PAS(0.008)TGAK 281.61 2.275699999999999e-131 0.0 1598.8 1720.9 2016.1 2187.3 1512.4 1266.0 1854.1 1653.2 807.93 1440.6 True False 1636.0489292767486 1519.416227975295 1742.3246936445878 1805.3291157061446 1375.6036870359064 1253.2651894360297 1714.2437442555256 1609.351765649588 1370.9982011275074 1625.5150426323025 1.0064803378425757 0.9347291093134427 1.0718600861565253 1.1106197533445508 0.8462571252544681 0.7709957500033562 1.054584977250988 0.9900565195899139 0.8434238780758132 1.0 10.66668119155508 -6.2656761074714 24.860220129124784 0.9165796022175636 1.0269755030256342 0.27575679386331153 0.08990851943739231 512.6421224705953 3008069.5313864793 0.029357085928979443 0.03447703636031606 5.424052600729676e-07 6.2656761074714 0.1103959008080706 TSLAGDTSNSSS(ph)PASTGAK ddPTM_A459_Selumetinib_30min_R2 1 TSLAGDTSNSSSPASTGAK 19 0 H3BQK9;H3BPE1;Q9UPN3;A0A590UJG2;Q9UPN3-2;Q9UPN3-3;Q9UPN3-4;Q9UPN3-5;H0Y390;H0Y4F5;H0Y314;H0Y6T5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 1 TSLAGDTSNSS(0.023)S(0.977)PASTGAK 301.38 2.570299999999998e-100 4787800.0 21315.0 23929.0 24542.0 23768.0 24913.0 18996.0 25499.0 22150.0 17405.0 25738.0 True False 20130.39763070557 25764.277356137925 22962.994439309226 20530.757397913072 21783.206214954167 21612.526571480925 26684.754025309947 22214.452832870105 20886.486336332506 24994.87706464498 0.8053809418082648 1.0307823194930315 0.9187080368476853 0.8213986147966951 0.8715068355253608 0.8646782504904431 1.067608932674259 0.8887602357641614 0.8356306887332623 1.0 14.609344810805204 TSLDIEEYS(ph)DTEVQK ddPTM_A459_Selumetinib_30min_R1 4 TSLDIEEYSDTEVQK 15 0 P51580 P51580 TPMT Thiopurine S-methyltransferase 1 TSLDIEEYS(0.963)DT(0.037)EVQK;TSLDIEEYS(0.952)DT(0.048)EVQK;TSLDIEEYS(0.996)DT(0.004)EVQK;TSLDIEEYS(0.99)DT(0.01)EVQK 297.72 1.9328999999999997e-80 33816500.0 8510.2 10413.7 10147.900000000001 10520.3 9483.7 8699.4 9774.400000000001 8822.7 4944.139999999999 8662.0 True False 8708.471102033396 9194.459162802212 8769.870918424644 8683.127095489119 8625.901009483228 8611.891934423218 9037.109138585409 8588.693335831487 8389.844474301675 9773.852075024986 0.890996818366635 0.9407201062820164 0.897278867237432 0.8884037766109654 0.8825487579789442 0.8811154361982916 0.924621026511935 0.8787418992945554 0.8583969155559608 1.0 13.254711554558437 -10.5601852732273 4.482960779389375 1.0000044146892182 0.89476178480407 0.6712982048176959 0.022313892266123292 6875655.213286438 8098241.013522622 269.7239640352026 0.005617398154286737 2.7530539796617548e-11 10.5601852732273 -0.10524262988514821 TSLDIEEYS(ph)DTEVQK ddPTM_A459_Selumetinib_30min_R2 2 TSLDIEEYSDTEVQK 15 0 P51580 P51580 TPMT Thiopurine S-methyltransferase 1 TSLDIEEYS(0.999)DT(0.001)EVQK;TSLDIEEYS(0.992)DT(0.008)EVQK 252.12 3.3910999999999997e-28 16121200.0 122394.0 101871.0 113489.0 113525.0 119942.0 83505.0 97465.0 102675.0 75962.0 110898.0 True False 115591.83146200201 109684.17813310731 106187.24129748056 98062.69915845193 104873.8136649153 95007.05576708345 101997.31562323358 102973.76725123868 91156.52255561581 107696.08659239231 1.0733150583223463 1.0184602022563691 0.9859897853055476 0.9105502554572777 0.973794099518595 0.882177419562753 0.9470846977873261 0.956151430469088 0.8464237229029931 1.0 16.716606301326124 -5.125446428574625 1.1759299284105005 0.9277500765538622 1.0960906679475984 0.5463096924785404 0.042760950385689826 0.6650853709840104 1.1601729780243268 0.012899863633210683 0.11878974215025173 7.491237592990894e-06 5.125446428574625 0.16834059139373614 TSLEASMEAS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TSLEASMEASPK 12 0 A0A0A0MRP0;Q8IWC1-2;Q8IWC1-4;Q8IWC1;Q8IWC1-3 A0A0A0MRP0 MAP7D3 MAP7 domain-containing protein 3 1 TSLEAS(0.001)MEAS(0.999)PK 179.67 8.4695e-09 0.0 2429.8 2927.9 3227.7 3457.2 2053.8 2296.9 2687.6 2029.4 1521.8 2190.7 True False 2486.4096124322273 2585.100106856217 2789.396068487 2853.464919681472 1868.03415262784 2273.795271418339 2484.872168200827 1975.573719579768 2582.3834521256044 2471.897684225033 1.0058707641096172 1.045795755768376 1.1284431739582725 1.1543620668005377 0.7557085248912675 0.9198581664318354 1.0052487949070845 0.7992133866168218 1.0446967399199656 1.0 11.271403313698864 -6.241096290100857 24.952275395296393 0.9149248434763882 1.0841181593592562 0.4259153560799722 0.0924610520469468 754.9271699056271 925973.1007471738 0.026821416016994195 0.03458446724335063 5.739891854253759e-07 6.241096290100857 0.1691933158828679 TSLITEEEDS(ph)TSEVLDEELK ddPTM_A459_Selumetinib_30min_R1 2 TSLITEEEDSTSEVLDEELK 20 0 D6RB01;Q9Y6X4 D6RB01 FAM169A Soluble lamin-associated protein of 75 kDa 1 TSLITEEEDS(0.569)T(0.431)SEVLDEELK;TSLITEEEDS(0.535)T(0.445)S(0.019)EVLDEELK 180.63 1.5917999999999998e-13 6058300.0 2388.1099999999997 2874.1000000000004 2410.8599999999997 2230.69 2447.12 2384.47 2577.26 2905.7 1614.88 2896.7 True False 2443.748316546845 2537.599035867161 2083.4784539060515 1841.14186673732 2225.7784280741275 2360.484396725537 2382.8552032360703 2828.631396956209 2740.3334138313817 3268.519661247389 0.7476621130723807 0.7763756375565808 0.6374379443417263 0.5632953316960227 0.6809744651267257 0.7221876082656599 0.729031931943981 0.8654166687425394 0.8384019977978557 1.0 11.674421660160084 -8.123442431444854 0.8736636794982511 0.9860448086588263 0.6779324525283681 0.7329552054490327 0.06059022871675368 0.31249021404624255 0.48044322879516177 0.06281704418349898 0.023904018166679294 7.525884840549828e-09 8.123442431444854 -0.3081123561304582 TSLPLS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 TSLPLSPVK 9 0 Q86XL3;Q86XL3-2 Q86XL3 ANKLE2 Ankyrin repeat and LEM domain-containing protein 2 1 T(0.146)S(0.007)LPLS(0.846)PVK;T(0.001)S(0.001)LPLS(0.998)PVK 128.08 0.0044095 36453000.0 450480.0 285910.0 391300.0 422680.0 381190.0 308560.0 453630.0 391300.0 354940.0 417020.0 True False 425444.12501432013 307838.3776544524 366124.1840152266 365110.2548363301 333301.5043181622 351061.3391712025 474724.69385079195 392438.61821679794 425937.91785221745 404979.5490519181 1.05053236888211 0.760133143451616 0.9040559822646494 0.9015523270028709 0.8230082360910358 0.8668618946143295 1.172218930467357 0.9690331749727135 1.0517516720273017 1.0 18.627489530023368 -7.23179001675554 24.78861510119616 1.0456703855226184 0.8775991374973725 0.4709434317354475 0.08490224295973348 517.4586515226957 432626.507699653 0.03061730948252509 0.02371271587454625 5.8642163335388564e-08 7.23179001675554 -0.16807124802524587 TSLPTVGPSGLYS(ph)PSTNR ddPTM_A459_Selumetinib_30min_R2 1 TSLPTVGPSGLYSPSTNR 18 0 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 TSLPTVGPS(0.165)GLY(0.011)S(0.669)PS(0.056)T(0.1)NR 97.214 0.003569699999999999 4936800.0 35012.0 29346.0 32001.0 25507.0 28763.0 21459.0 26591.0 25911.0 20087.0 26594.0 True False 33066.173204140905 31596.743837737613 29942.09050005437 22032.902597970748 25149.534795517462 24414.782464593038 27827.534189066908 25986.396720203044 24104.96127767372 25826.16212048989 1.28033631361382 1.2234393825271264 1.1593705003616854 0.8531233752494082 0.973800701714189 0.9453507784349772 1.0774939791378904 1.0062043519654833 0.9333543700846434 1.0 14.656545648203997 -5.584687335225596 5.463893182000692 0.9742246983335013 1.2387598269383495 0.8117895476558886 0.05642663054153372 0.08133766135949573 4.774961497415953 0.016283339910984164 0.028976068525844625 2.602032188892842e-06 5.584687335225596 0.2645351286048482 TSLQGLTGTPLVAGS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 1 TSLQGLTGTPLVAGSPIR 18 0 Q96A47 Q96A47 ISL2 Insulin gene enhancer protein ISL-2 1 TSLQGLTGT(0.002)PLVAGS(0.997)PIR 141.93 0.00030566 4571900.0 15275.0 10401.0 13297.0 17271.0 15496.0 13882.0 15679.0 15464.0 14458.0 12068.0 True False 14426.076650669824 11198.72325551383 12441.485496678955 14918.660005863203 13549.253944002316 15794.119491750804 16408.1045673491 15508.99767979698 17350.003990272642 11719.565483570426 1.2309395489870025 0.9555578891737274 1.0615995545330228 1.2729704037899328 1.1561225510448248 1.3476710816533655 1.4000608290769399 1.323342380017325 1.480430653729909 1.0 13.516631460715836 -6.190884824334106 1.2784618869570852 1.330970136719706 1.0740680349317102 0.26901844996841984 0.1424423173167143 0.4931311026385623 1.6384439064313068 0.05321718687836389 0.08165640978578691 6.443401230003015e-07 6.190884824334106 -0.2569021017879958 TSLS(ph)PTSK ddPTM_A459_Selumetinib_30min_R1 2 TSLSPTSK 8 0 Q8NDI1-3;Q8NDI1-2;Q8NDI1;H7C0Q4 Q8NDI1-3 EHBP1 EH domain-binding protein 1 1 TSLS(0.997)PT(0.003)SK;T(0.001)SLS(0.536)PT(0.426)S(0.037)K 167.93 0.00022492 160022000.0 15781.7 19013.0 20034.8 21791.0 17483.800000000003 15869.2 19213.0 17826.800000000003 10170.6 14807.5 True False 16149.382904157419 16786.949121096106 17314.184203278914 17985.610917730814 15902.393377015598 15709.570256080759 17763.747941524965 17353.97535439273 17258.765368766388 16708.186862264207 0.9665550808885878 1.004713991977776 1.036269485492969 1.0764549777900614 0.9517725357101129 0.9402318986245692 1.0631762792673074 1.0386510216489768 1.0329526184403452 1.0 14.02826756317323 -7.31276532125513 24.999511709246512 1.0369158820651663 0.9998726927889031 0.16776549521734285 0.040329695872917466 737.6956014614874 359309.37069582875 0.01827790230350981 0.01232299241300992 4.866701155007707e-08 7.31276532125513 -0.037043189276263155 TSMPS(ph)GDESIDEK ddPTM_A459_Selumetinib_30min_R2 2 TSMPSGDESIDEK 13 0 Q03468 Q03468 ERCC6 DNA excision repair protein ERCC-6 1 T(0.007)S(0.005)MPS(0.988)GDESIDEK;T(0.067)S(0.015)MPS(0.904)GDES(0.014)IDEK 115.12 0.0040667 13510700.0 50399.0 49006.0 47173.0 42637.0 46150.0 35920.0 33596.0 39747.0 28171.0 49502.0 True False 47598.02534318225 52764.60262087401 44137.94053807895 36829.767047072506 40352.22441376532 40867.65395070517 35158.28056921108 39862.65718952995 33805.98716350608 48072.748638357916 0.9901248980218103 1.0975990371969786 0.9181488845191736 0.7661256759861141 0.8393991514262555 0.8501210167561815 0.7313557382312397 0.8292152689127282 0.7032255928992546 1.0 15.552931673841995 -5.509882965136902 4.02037501662308 0.8093747283441803 1.0410008123493433 0.5570609640099323 0.0804739034499247 0.1353143391803102 4.975974499961257 0.02046746986062134 0.04161223110998298 3.0911283259869057e-06 5.509882965136902 0.23162608400516294 TSNRYS(ph)PESQAQSVHHQRPGSR ddPTM_A459_Selumetinib_30min_R2 1 TSNRYSPESQAQSVHHQRPGSR 22 2 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 T(0.141)S(0.141)NRY(0.185)S(0.475)PES(0.058)QAQSVHHQRPGSR 55.051 0.010645 3890500.0 2772.6 2811.8 5317.7 9942.3 7665.8 3990.4 3212.6 3823.6 5152.4 6594.5 True False 2618.509991597194 3027.4560186379945 4975.564971473992 8588.141588575865 6702.7536708784855 4540.041378755395 3361.9922656461345 3834.7260429689445 6183.023970084437 6404.099650431322 0.4088802695974344 0.4727371814762584 0.7769343456638567 1.3410380939336954 1.0466348178119074 0.7089273475701803 0.5249750080668563 0.598792375554411 0.9654790380515089 1.0 12.644780041620654 -5.285892565051137 4.2449203573541014 0.8644332104667886 0.43107984624255247 0.37470801397056064 0.22415306973909696 0.24133449803217435 10.513666019631952 0.06745461254205537 0.16447498382321374 5.1773489239029e-06 5.285892565051137 -0.4333533642242361 TSNS(ph)LTEDSK ddPTM_A459_Selumetinib_30min_R1 1 TSNSLTEDSK 10 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.004)S(0.003)NS(0.729)LT(0.218)EDS(0.047)K 122.52 0.0044393 11835000.0 3954.7 4612.5 4810.7 5187.7 3944.5 4033.0 4507.3 4060.3 2619.4 3871.3 True False 4046.8368154933446 4072.4663557069266 4157.43336328358 4281.765580189623 3587.720671458037 3992.4316816710157 4167.310732151949 3952.6076542868495 4444.930486593384 4368.219064655305 0.9264271675927679 0.9322944420664679 0.9517456202970079 0.9802085281928267 0.821323431438561 0.913972404446263 0.95400680929009 0.9048556392852858 1.017561257986985 1.0 12.09282949338482 -8.265533073907058 24.936756446548365 1.0087806419126946 0.9236017782125217 0.4223038617936957 0.040079438799309315 361.5059799643587 2202067.7010432114 0.035274060007688596 0.010393201432517684 5.4258392901311225e-09 8.265533073907058 -0.08517886370017291 TSNS(ph)LTEDSK ddPTM_A459_Selumetinib_30min_R2 1 TSNSLTEDSK 10 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.001)SNS(0.934)LT(0.045)EDS(0.02)K 101.32 0.016483 12458000.0 24609.0 25262.0 26352.0 27284.0 23468.0 19275.0 23961.0 22716.0 17510.0 23853.0 True False 23241.33029763234 27199.514169867372 24656.541009888217 23567.872132474753 20519.740033418075 21929.95628897109 25075.23397782077 22782.09979916376 21012.48927027762 23164.30191246315 1.0033253056992728 1.1741996056109572 1.0644197741448964 1.0174220756376202 0.8858345963094958 0.9467134546874498 1.0824946969081541 0.983500382841507 0.9071065188876776 1.0 14.499615585011377 -5.825821363314519 3.227304140487877 0.9705076349356195 1.092929285077015 0.3809775306415303 0.06390245250792306 0.24712584891468453 5.188924758289934 0.018983314807008683 0.031233951973554015 1.4934085612843424e-06 5.825821363314519 0.12242165014139539 TSNSLT(ph)EDSK ddPTM_A459_Selumetinib_30min_R2 1 TSNSLTEDSK 10 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.003)SNS(0.122)LT(0.867)EDS(0.008)K 97.957 0.046948 8335500.0 52169.0 56459.0 54455.0 66700.0 58251.0 45576.0 50062.0 59743.0 45986.0 62648.0 True False 49269.65582905363 60789.223755701874 50951.424586121066 57615.34493608213 50932.98860945269 51853.68030226443 52389.98219597105 59916.84223901392 55184.48495619574 60839.18946094791 0.8098341918358288 0.9991787250012903 0.8374770446083325 0.9470103965317431 0.8371740166286417 0.8523072177933733 0.8611222907497753 0.9848395872774399 0.9070549007168829 1.0 15.892713312222964 -7.758990635382699 24.99998757285524 0.9594604397723171 0.8809791905668731 0.31636983822056197 0.057839843238522724 81.17314306360089 828750.2912977703 0.02729531270746608 0.014803989782108352 1.7418444320789142e-08 7.758990635382699 -0.07848124920544397 TSNSLTEDS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 TSNSLTEDSK 10 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.182)S(0.002)NS(0.093)LT(0.142)EDS(0.582)K 110.31 0.0095397 13784000.0 4030.2 5269.8 5302.1 6221.9 4374.7 4907.5 4561.0 4680.2 3061.3 4275.8 True False 4124.095818595917 4652.809366136444 4582.103942350567 5135.361964527986 3979.0091574160137 4858.135005653485 4216.960097917836 4556.065892567866 5194.802511494362 4824.6405798189635 0.8547985596785465 0.9643846601959793 0.9497295946805022 1.064403011906989 0.8247265452394216 1.0069423670593465 0.8740464762405307 0.9443327056580089 1.0767232139993501 1.0 12.23620575491289 -8.216271107046666 9.512403431760418 1.0382485662925267 0.937743514832803 0.25903489335410057 0.069555619091042 0.603397603304516 124.87011369690677 0.045033387081255385 0.016864722358972004 6.0775549326736105e-09 8.216271107046666 -0.10050505145972366 TSPADHGGSVGSESGGSAVDSVAGEHSVS(ph)GR ddPTM_A459_Selumetinib_30min_R1 1 TSPADHGGSVGSESGGSAVDSVAGEHSVSGR 31 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;X6RE05;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 TSPADHGGSVGSESGGSAVDS(0.055)VAGEHS(0.219)VS(0.725)GR 85.331 8.9654e-07 8105000.0 1407.8 1585.9 1559.0 1618.9 1565.0 1212.7 1178.0 1528.1 701.54 1142.9 True False 1440.5990008980527 1400.2220907350918 1347.2963629740166 1336.1895055167004 1423.4460263231906 1200.5013390435017 1089.1425115867585 1487.5698240316553 1190.4621415456677 1289.602347788739 1.117087762261154 1.0857781804879858 1.044737833553269 1.036125211626548 1.1037867826186507 0.9309081525029654 0.8445568616204011 1.1535104806395304 0.9231234291616593 1.0 10.332710560145015 -6.757563815714428 24.998721940573052 0.9721477544797695 1.0738438132253114 0.3255132367075517 0.07696143670827099 132.05058743504776 851770.8542737062 0.026117323514401426 0.025197811001039468 1.747576452722168e-07 6.757563815714428 0.10169605874554188 TSPASLDFPESQKS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 TSPASLDFPESQKSSR 16 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 TSPASLDFPES(0.004)QKS(0.581)S(0.415)R 70.094 0.023914 6520600.0 1608.1 1995.2 2280.7 2354.6 2225.8 2345.8 2000.1 1821.1 1263.5 1968.4 True False 1645.5656011820993 1761.6010564566839 1970.9934669883496 1943.4133113160924 2024.4767829969073 2322.203381815986 1849.2308467102519 1772.7985122335256 2144.0672176111866 2221.063313839665 0.7408909016363546 0.7931341017970868 0.8874098521671554 0.8749923062555182 0.9114899023283993 1.0455367784187453 0.8325880830084904 0.7981755860749411 0.9653336779061145 1.0 11.117034803733645 -5.085482132193911 1.3307860788598644 0.9135403087632721 0.710088305259603 0.43343551815491943 0.06970163143803192 0.8484126275946904 1.9457288324531183 0.02205569164274387 0.20187632016838244 8.213303434306572e-06 5.085482132193911 -0.2034520035036691 TSPASLDFPESQKS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 TSPASLDFPESQKSSR 16 1 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 TSPASLDFPES(0.008)QKS(0.599)S(0.393)R 65.765 0.030172000000000008 6995800.0 27382.0 26368.0 25253.0 25555.0 27236.0 19563.0 18051.0 16902.0 12649.0 24913.0 True False 25860.218058830855 28390.34081351685 23628.249473387492 22074.36491516612 23814.370187070683 22257.62567476741 18890.40726737793 16951.182021723263 15179.153442589472 24193.69695825239 1.0688824491541802 1.173460214141973 0.9766283141497304 0.9124014801564515 0.9843212564067304 0.9199762117039912 0.7807987055460938 0.7006445542809558 0.6274011561268198 1.0 14.562343619136522 -6.411723225043078 0.7165040457716019 0.7512360111321189 1.1104913451517182 0.5421920500606308 0.1076243037650806 0.5408090471163691 0.6130157689141931 0.07002625780288106 0.1047875513817753 3.8750452206036644e-07 6.411723225043078 0.3592553340195993 TSPAVDLEEEEEES(ph)SVDGK ddPTM_A459_Selumetinib_30min_R2 1 TSPAVDLEEEEEESSVDGK 19 0 A0A5F9ZHW8;O94827-5;O94827-3;O94827;O94827-7;O94827-2;O94827-6;Q5SY18;O94827-4 A0A5F9ZHW8 PLEKHG5 Pleckstrin homology domain-containing family G member 5 1 TSPAVDLEEEEEES(0.551)S(0.449)VDGK 54.412 0.040371 20245000.0 18326.0 24988.0 57966.0 60459.0 84548.0 50553.0 23711.0 43583.0 54033.0 59579.0 True False 17307.514284790523 26904.499250916237 54236.53066860884 52224.3799024077 73926.32437129 57516.21687555675 24813.608482455165 43709.819314445966 64841.10980816169 57858.79946516757 0.29913365719262935 0.4650027221375966 0.9373946775591252 0.9026177588397435 1.277702355642472 0.994078988973543 0.4288649040738146 0.755456727731801 1.120678451809178 1.0 15.820248768084538 -5.164116212097822 3.3695083212907413 0.9162344104464627 0.3267155126246866 0.5166101116164181 0.2128968834317998 0.22015366521535934 4.632369881597642 0.06119692632358128 0.20021986914438392 6.8530482240129265e-06 5.164116212097822 -0.589518897821776 TSPDTLRR ddPTM_A459_Selumetinib_30min_R1 2 TSPDTLRR 8 1 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 0 ; 95.741 0.031279 0.0 2039.31 2358.8599999999997 3580.0 3584.4 3096.7 2515.5 2468.6 2335.27 1680.1599999999999 2102.8 False True 2086.8219551935 2082.6835745957374 3093.8556635323766 2958.4518275211917 2816.60403176679 2490.196353891258 2282.391514518737 2273.3310535739843 2851.1088059688245 2372.7148630065285 0.8795081059800138 0.8777639517783081 1.3039306626216653 1.246863613343097 1.1870807047576706 1.049513530983603 0.9619324892779825 0.9581138842336021 1.2016230228170404 1.0 11.212323022175383 -6.984997862078075 23.661855922366478 1.0238977003146674 1.1075297054772058 0.04668431379297966 0.14471571266714262 420.7755186138379 663655.2747016181 0.056252814137215515 0.04958522543554187 1.0351472624350429e-07 6.984997862078075 0.08363200516253833 TSPDTLRR ddPTM_A459_Selumetinib_30min_R2 1 TSPDTLRR 8 1 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 0 93.429 0.035474 0.0 3524.6 3418.6 3339.5 3790.8 2899.5 2085.9 927.7 2763.3 1191.0 3760.1 False True 3328.716842091711 3680.7956274684734 3124.6402057726823 3274.4865005052534 2535.2388881411152 2373.213791085076 970.8398882026762 2771.3407455110596 1429.2332793204253 3651.536143086935 0.9115935627239008 1.0080129247623448 0.8557056765515606 0.8967421852593436 0.6942937954868154 0.6499220322871593 0.2658716359800146 0.7589520237278068 0.3914060338759731 1.0 11.834287795172868 -6.382210462233171 1.8636579038182837 0.5753424079507139 0.9333916463944819 0.36259320367996795 0.18953748380640217 0.33371366760412813 2.294091161562722 0.0647149163479173 0.07785951627053747 4.147530016342201e-07 6.382210462233171 0.358049238443768 TSPPLLDR ddPTM_A459_Selumetinib_30min_R2 1 TSPPLLDR 8 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 153.04 0.012693 8430600.0 22770.0 24526.0 21471.0 28485.0 26438.0 21282.0 26716.0 22044.0 18975.0 28503.0 False True 21504.534555532035 26407.065336480366 20089.579235857243 24605.29386063419 23116.622081281184 24213.402321239053 27958.346936749705 22108.144390419355 22770.530205797728 27680.04433031221 0.7768966804718076 0.9540109481530774 0.7257784343162087 0.8889181522621016 0.8351367434757445 0.874760243599868 1.0100542688124503 0.7987033592359132 0.8226334442991441 1.0 14.756558633039635 -6.920908788797968 5.4734411098308895 0.8977786622586492 0.8400938150442683 0.13320168377336816 0.0842800712839494 0.524864423984416 26.911666190922706 0.029608472988707155 0.025984685705519914 1.1997512503134249e-07 6.920908788797968 -0.05768484721438094 TSPS(ph)SPAPLPHQEATPR ddPTM_A459_Selumetinib_30min_R1 2 TSPSSPAPLPHQEATPR 17 0 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 T(0.034)S(0.034)PS(0.466)S(0.466)PAPLPHQEATPR;TSPS(0.5)S(0.5)PAPLPHQEATPR 219.85 6.7265e-12 29682000.0 11585.099999999999 13393.5 12802.5 13122.5 13999.3 11232.7 12287.400000000001 12568.099999999999 5992.299999999999 11105.400000000001 True False 11855.010289319527 11825.382793530776 11063.990819098684 10830.901714832848 12733.06578677715 11119.709236475586 11360.551525357514 12234.753161057697 10168.495439724184 12530.88626575646 0.9460631944059759 0.9436988368369733 0.8829376138648384 0.8643364471698053 1.0161344949377755 0.8873841004257423 0.9066039930793118 0.9763677445937711 0.81147456166065 1.0 13.613200834591892 -1.9166362410394893 10.06162319616316 0.9217351722309302 0.9281497809537953 0.0 0.06120604848862408 0.0 0.0 0.013123550886583242 0.0 0.012116125383165338 1.9166362410394893 0.006414608722865145 TSPS(ph)SPAPLPHQEATPR ddPTM_A459_Selumetinib_30min_R2 1 TSPSSPAPLPHQEATPR 17 0 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 T(0.001)S(0.001)PS(0.499)S(0.499)PAPLPHQEATPR 139.81 0.00033436 42429000.0 14103.0 6780.3 9183.2 15325.0 9167.1 8465.7 16111.0 12667.0 7013.2 8767.2 True False 13319.211718782097 7300.327207899279 8592.362909912172 13237.708562900447 8015.446943086196 9631.773331026858 16860.193423340857 12703.858872865268 8416.035965180534 8514.068156078769 1.5643769200123927 0.857442890292942 1.0091959275399391 1.5548041570995825 0.9414356094111634 1.1312774521484283 1.9802746600405383 1.492102087977194 0.9884858578647573 1.0 13.055632923764945 TSPSGGTWSSVVSGVPRLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 TSPSGGTWSSVVSGVPRLSPK 21 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4 Q99700 ATXN2 Ataxin-2 1 TSPSGGTWSSVVS(0.001)GVPRLS(0.999)PK;TSPSGGTWSSVVSGVPRLS(1)PK 77.675 0.0014069 109764000.0 2746.8 2405.3 4521.8 4494.5 3168.6000000000004 2725.3999999999996 2826.1000000000004 3077.9 1752.41 2358.8999999999996 True False 2810.7950956576037 2123.686357806367 3907.7643964694707 3709.6199472140383 2882.0006894617663 2697.9849504652075 2612.925001693836 2996.264093571778 2973.7117790376064 2661.687792631776 1.0560198320173366 0.7978720733833875 1.468152804129451 1.3937096444906887 1.0827718778437772 1.0136368953315678 0.9816797480632672 1.1257008060322453 1.1172278684485804 1.0 11.378125642374236 -6.503024338194741 24.619819000159076 1.0510291511377805 1.180610587574386 0.11139872383126648 0.17574782558248397 1655.5497076796623 2052914.7194052045 0.0601402153192935 0.06722328202159203 3.1403327022998047e-07 6.503024338194741 0.12958143643660547 TSPSGGTWSSVVSGVPRLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 TSPSGGTWSSVVSGVPRLSPK 21 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;A0A5F9ZHX3;A0A5F9ZHH4 Q99700 ATXN2 Ataxin-2 1 TSPSGGTWSSVVSGVPRLS(1)PK;TSPSGGTWSSVVS(0.001)GVPRLS(0.998)PK 121.5 4.0254e-05 14847300.0 32774.0 44891.0 38208.0 34272.0 36353.0 21989.6 21099.9 23286.2 14567.5 33158.0 True False 30952.552284717032 48333.99535268448 35749.73887772501 29604.094477502396 31786.011140056555 25018.4677982858 22081.087158658673 23353.95898676207 17481.40704995827 32200.64238516971 0.9612402111261141 1.5010258110547858 1.1102181891312164 0.9193634749080913 0.9871235101413965 0.776955549489543 0.6857343681077714 0.7252637604993228 0.542890009486565 1.0 14.9748018491519 -6.174028067724781 1.0244590284437918 0.7166898803706556 1.2421110694155018 0.5364580506586607 0.1724885926330231 0.3769251393168328 0.8241504862297788 0.0732737062493435 0.12507393629504 6.698413172954577e-07 6.174028067724781 0.5254211890448461 TSPSS(ph)PAPLPHQEATPR ddPTM_A459_Selumetinib_30min_R2 1 TSPSSPAPLPHQEATPR 17 0 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 T(0.004)S(0.004)PS(0.137)S(0.854)PAPLPHQEATPR 143.33 0.00032849 39060000.0 31095.0 13880.0 22538.0 21369.0 15585.0 11293.0 30119.0 21828.0 15114.0 17698.0 True False 29366.864383147502 14944.551368765704 21087.929617519003 18458.50533641889 13627.072968332222 12848.508242352826 31519.593179666263 21891.515866180085 18137.2223204441 17187.012755073687 1.708666002733853 0.8695258205562222 1.2269688699273087 1.0739798474269389 0.7928703587137006 0.747570763195011 1.833919228945794 1.2737243044005775 1.0552864874723449 1.0 14.069031193827394 TSPTT(ph)PEASAT(ph)NSPCTSKPATPAPSEK ddPTM_A459_Selumetinib_30min_R2 1 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 2 T(0.013)S(0.017)PT(0.21)T(0.749)PEAS(0.237)AT(0.623)NS(0.137)PCT(0.01)S(0.002)KPAT(0.001)PAPSEK 73.27600000000002 0.00048864 11428000.0 66232.0 48033.0 62412.0 60200.0 57429.0 40834.0 52231.0 56276.0 40214.0 51768.0 True False 62551.09058770301 51716.97664956214 58396.47986904766 52000.656149207614 50214.255598225944 46458.51284585454 54659.844993763065 56439.75384300665 48257.923673040816 50273.32333058286 1.2442203229013744 1.0287160908278576 1.1615798598602536 1.034358834948434 0.9988250680789789 0.9241185934806173 1.0872534651098298 1.1226581038192984 0.9599111512026098 1.0 15.617505441450744 -1.5228787851280559 0.7737323365637554 1.0260570766248915 42.11712996379021 0.44860093801604295 0.06895735609639385 438.3636289255452 1.7094340221272137 0.02584963105266645 31486.14383797844 0.02999999724741726 1.5228787851280559 41.09107288716532 TSPTT(ph)PEASATNS(ph)PCTSKPATPAPSEK ddPTM_A459_Selumetinib_30min_R2 1 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 2 T(0.041)S(0.017)PT(0.127)T(0.467)PEAS(0.356)AT(0.363)NS(0.541)PCT(0.076)S(0.01)KPAT(0.002)PAPSEK 69.095 0.0027148000000000003 9072900.0 34237.0 22656.0 23675.0 31848.0 27042.0 19763.0 24725.0 24505.0 18622.0 23144.0 True False 32334.244601570066 24393.642349478057 22151.776275391003 27510.2474591356 23644.7422014527 22485.173859348164 25874.76149165804 24576.30549297885 22346.92034215363 22475.77258466639 1.438626613602124 1.085330537919755 0.9855846419492416 1.2239956315407763 1.0520102084314475 1.0004182848285352 1.1512290131156842 1.093457650917215 0.9942670605859099 1.0 14.456083087498733 -4.762557150115033 6.0932187275451515 1.0699464554399911 1.4513539112430582 0.7000894494988879 0.07334158400361851 0.07126005542591717 10.60372758195519 0.01782640027789437 0.11355297066272547 1.7275986256580178e-05 4.762557150115033 0.3814074558030671 TSPTTPEAS(ph)ATNSPCTSKPAT(ph)PAPSEK ddPTM_A459_Selumetinib_30min_R2 1 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 2 T(0.016)S(0.011)PT(0.042)T(0.165)PEAS(0.561)AT(0.119)NS(0.087)PCT(0.019)S(0.173)KPAT(0.807)PAPS(0.002)EK 79.17699999999998 0.0003781 6011200.0 47606.0 39003.0 42352.0 50819.0 39573.0 41013.0 47551.0 47259.0 32156.0 44021.0 True False 44960.249101917376 41994.404685588495 39627.11842937107 43897.36453233523 34601.485952891315 46662.16847105432 49762.21572051895 47396.51586585138 38588.09851370916 42749.99934970613 1.0517017493762006 0.9823252707459321 0.9269501527990894 1.026838952048709 0.8093914965902607 1.0915127293768037 1.164028455613556 1.1086904464754617 0.9026455929986914 1.0 15.383636777602353 TSPTTPEASATNS(ph)PCTSKPATPAPSEK ddPTM_A459_Selumetinib_30min_R1 2 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 TSPTT(0.002)PEAS(0.165)AT(0.165)NS(0.658)PCT(0.004)S(0.006)KPATPAPSEK;TSPTTPEAS(0.068)AT(0.068)NS(0.858)PCT(0.006)SKPATPAPSEK 112.6 2.9044e-10 30471000.0 4917.4 5048.799999999999 4273.5 4152.7 3983.6000000000004 4423.0 5001.299999999999 4351.2 2525.4 4910.7 True False 5031.96585240523 4457.68414887656 3693.1821726552002 3427.5089008334066 3623.284083361702 4378.508635762686 4624.047914430269 4235.792041310477 4285.419352081748 5541.036179268671 0.9081272328146701 0.8044856602009959 0.6665147191193114 0.6185682226109889 0.653900094880795 0.7901967238807273 0.8345096052126066 0.7644404231032352 0.7733967462828145 1.0 12.435940071570242 -9.567934786374648 0.5594833914991579 1.020148404669434 0.7388066438867551 0.4358424191247873 0.08350354921255736 4.868683027408171 1.7558989707601995 0.3165813729504172 0.04134863781981814 2.70436442077075e-10 9.567934786374648 -0.2813417607826789 TSPTTPEASATNS(ph)PCTSKPATPAPSEK ddPTM_A459_Selumetinib_30min_R2 3 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 TSPTTPEAS(0.023)AT(0.089)NS(0.809)PCT(0.039)S(0.039)KPATPAPSEK;TSPTTPEAS(0.013)AT(0.059)NS(0.639)PCT(0.214)S(0.073)KPAT(0.002)PAPSEK;TSPTTPEAS(0.062)AT(0.265)NS(0.62)PCT(0.026)S(0.026)KPAT(0.001)PAPSEK 103.71 1.2804e-07 45514000.0 153239.0 120495.0 145011.0 160285.0 158959.0 128377.0 144562.0 158317.0 119882.0 146505.0 True False 144722.58984432032 129736.57904750886 135681.15013603878 138453.9064929527 138989.1493085095 146059.76645962364 151284.41944416883 158777.67625920966 143861.7497829481 142275.0199842963 1.0172030892021255 0.9118718033694786 0.9536540578311968 0.9731427660894698 0.9769047955421165 1.0266016232206123 1.0633238319760345 1.1159912420095592 1.0111525536867045 1.0 17.118322856551835 -6.8117213164107975 2.2038202343704714 1.056940858957437 0.9601264665440826 0.501646109710604 0.03835065239483341 0.2233623990376329 2.2260498486441325 0.014894181806696726 0.013284567340248781 1.5426900683226446e-07 6.8117213164107975 -0.09681439241335432 TSPTTPEASATNS(ph)PCTSKPATPAPSEKGEGIR ddPTM_A459_Selumetinib_30min_R1 1 TSPTTPEASATNSPCTSKPATPAPSEKGEGIR 32 2 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 TSPTTPEAS(0.032)AT(0.156)NS(0.665)PCT(0.073)S(0.073)KPATPAPSEKGEGIR 112.8 8.9804e-13 5179200.0 3449.6 3820.9 6360.7 6894.6 5695.0 5009.5 4339.2 4515.8 3197.7 3855.5 True False 3529.968968246859 3373.547251711782 5496.9518768241305 5690.587537670915 5179.888255533915 4959.108978262075 4011.8906504900397 4396.026314614329 5426.263349232522 4350.390980750269 0.811414188716914 0.7754584051500538 1.2635535291304152 1.308063473570717 1.1906718909757834 1.1399225955104446 0.9221908256618693 1.0104899385057546 1.2473047533526995 1.0 12.086929350138789 -5.249951228680718 24.94902228868132 1.1363546333241394 0.7934362362685237 0.5685327360069903 0.11911489524982166 559.4208267824528 1214898.3907496608 0.033456711886296786 0.08687271548717311 5.624044797306332e-06 5.249951228680718 -0.3429183970556158 TSPTTPEASATNSPCT(ph)SKPATPAPSEK ddPTM_A459_Selumetinib_30min_R2 1 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 TSPTTPEAS(0.01)AT(0.036)NS(0.346)PCT(0.484)S(0.119)KPAT(0.004)PAPSEK 69.649 0.0010162 13839000.0 19864.0 16747.0 17705.0 17427.0 21027.0 14589.0 20323.0 19031.0 12923.0 14910.0 True False 18760.038401892332 18031.441049907713 16565.87957574646 15053.412536748192 18385.40027623495 16598.502324243815 21268.05976926052 19086.377059248345 15507.961098789136 14479.509559167633 1.2956266457253383 1.2453074447187469 1.1440912075131615 1.0396355259986825 1.2697529706449429 1.146344236068034 1.468838407982869 1.3181646091848391 1.0710280645500416 1.0 13.821725116739938 -8.439166404170646 4.8994842056981724 1.0017389806651664 1.2359219083387274 0.3648760820525576 0.11004063187306003 0.23455945024463665 9.037599777890094 0.11409659206668195 0.02972019998137652 3.6377562523833407e-09 8.439166404170646 0.23418292767356097 TSPTTPEASATNSPCTSKPAT(ph)PAPSEK ddPTM_A459_Selumetinib_30min_R2 2 TSPTTPEASATNSPCTSKPATPAPSEK 27 1 Q12873-2;Q12873;Q12873-3 Q12873-2 CHD3 Chromodomain-helicase-DNA-binding protein 3 1 TSPTTPEASATNSPCTSKPAT(0.999)PAPS(0.001)EK;TSPTTPEASATNSPCTSKPAT(0.998)PAPS(0.001)EK 139.55 3.7547e-12 7556600.0 39699.0 27765.0 35292.0 37660.0 35086.0 26778.0 37633.0 39325.0 26926.0 31005.0 True False 37492.68850768848 29894.48622145387 33021.35114302426 32530.643032876385 30678.183007180258 30466.42643351844 39383.00906837479 39439.42923939577 32311.952375299577 30109.805089335496 1.2451986453066715 0.9928488787209755 1.0966976054826736 1.0804003193098821 1.0188768381647901 1.0118440269913689 1.3079795419308027 1.3098533558214467 1.073137214918208 1.0 14.877945748603098 -7.24656524846889 24.849413833823373 1.1985636503480925 1.0693828451060907 0.1424865511593968 0.1109117944913019 1077.26231199216 1799726.2980151062 0.041227089022553995 0.031806397326512116 5.668064080450729e-08 7.24656524846889 -0.12918080524200182 TSPVTASDPAGPSYAAATLQASSAASS(ph)ASPVSR ddPTM_A459_Selumetinib_30min_R1 1 TSPVTASDPAGPSYAAATLQASSAASSASPVSR 33 0 F5H8D7;P18887;M0QYS5;M0R1U8 F5H8D7 XRCC1 DNA repair protein XRCC1 1 TSPVTASDPAGPSYAAATLQASSAAS(0.042)S(0.509)AS(0.34)PVS(0.109)R 220.03 4.031999999999998e-70 18082000.0 2793.7 3326.0 3731.1 3946.2 3444.9 3007.9 2970.8 3291.3 1695.6 2719.5 True False 2858.7877744060884 2936.5903737845492 3224.4371134652674 3257.0702493483213 3133.309403246493 2977.643256954685 2746.7101641951967 3204.0040323508847 2877.3093582758406 3068.5743151732236 0.9316338731867106 0.956988513937547 1.0507932291296798 1.0614278537244606 1.0210961447970064 0.970367001454418 0.8951095466756335 1.0441344100770185 0.9376697654178905 1.0 11.583352807956183 -6.799935301877546 10.151582078693203 0.9675141868753925 1.0074924265569005 0.10175005078214405 0.05132365026883105 1.0350230469283632 264.62668936350855 0.019043354902178834 0.016860370018605818 1.5851293162349783e-07 6.799935301877546 0.03997823968150804 TSPVTASDPAGPSYAAATLQASSAASS(ph)ASPVSR ddPTM_A459_Selumetinib_30min_R2 1 TSPVTASDPAGPSYAAATLQASSAASSASPVSR 33 0 F5H8D7;P18887;M0QYS5;M0R1U8 F5H8D7 XRCC1 DNA repair protein XRCC1 1 TSPVTASDPAGPSYAAATLQASSAAS(0.016)S(0.467)AS(0.237)PVS(0.28)R 156.68 3.1385e-30 8100800.0 36917.0 31201.0 41657.0 39169.0 42089.0 30377.0 31617.0 31556.0 28174.0 31499.0 True False 34865.3009304601 33594.01637297252 38976.833972712244 33834.114629706186 36801.40353956593 34561.15601504929 33087.25314789697 31647.822735622973 33809.587247333075 30589.542025769366 1.139778454384467 1.098219003889372 1.2741882156940179 1.1060680346637264 1.2030714127254192 1.1298356799828562 1.0816524523323516 1.0345961606408518 1.1052662121862127 1.0 14.900750887161571 -7.251620469067218 2.4248700442863265 1.0530606654357715 1.1636737656296101 0.487909679460688 0.05313725213707276 0.2657346578267963 3.0744330082520657 0.024207634751902067 0.016127811232503793 5.6024698873983924e-08 7.251620469067218 0.11061310019383863 TSPVTASDPAGPSYAAATLQASSAASSAS(ph)PVSR ddPTM_A459_Selumetinib_30min_R1 1 TSPVTASDPAGPSYAAATLQASSAASSASPVSR 33 0 F5H8D7;P18887;M0QYS5;M0R1U8 F5H8D7 XRCC1 DNA repair protein XRCC1 1 TSPVTASDPAGPSYAAAT(0.001)LQAS(0.001)S(0.001)AAS(0.018)S(0.114)AS(0.648)PVS(0.217)R 64.61399999999999 0.00013565 21355000.0 2594.7 3200.3 3375.0 3370.0 3423.3 2966.1 2964.7 2772.0 1745.9 2372.6 True False 2655.151461592682 2825.6073882208943 2916.693537547981 2781.4927627347442 3113.6631194327033 2936.2637270033238 2741.0702921063375 2698.477555275016 2962.6647845091957 2677.146321081076 0.9917842146635033 1.0554549693346111 1.0894785670027074 1.038976742074946 1.1630530221356576 1.096788660329037 1.0238776530523919 1.0079679000082917 1.106650301920301 1.0 11.38648027718173 -10.325724620584966 10.393297714273737 0.9999999999999765 1.0646380472206467 0.1320352785308163 0.049014975177068834 0.0 0.0 0.0491347922432479 0.011916937547746496 4.723624640577107e-11 10.325724620584966 0.06463804722067024 TSPVTASDPAGPSYAAATLQASSAASSAS(ph)PVSR ddPTM_A459_Selumetinib_30min_R2 2 TSPVTASDPAGPSYAAATLQASSAASSASPVSR 33 0 F5H8D7;P18887;M0QYS5;M0R1U8 F5H8D7 XRCC1 DNA repair protein XRCC1 1 TSPVTASDPAGPSYAAATLQASSAAS(0.016)S(0.101)AS(0.666)PVS(0.217)R;TSPVTASDPAGPSYAAATLQASSAAS(0.005)S(0.063)AS(0.827)PVS(0.105)R 174.28 7.454e-36 10465900.0 80809.0 73127.0 89359.0 86171.0 100450.0 64169.0 61443.0 81576.0 59387.7 82272.0 True False 76317.95928405748 78735.6057596348 83609.7392267229 74434.3611467338 87830.57296560617 73007.69728181507 64300.22124699471 81813.37265436625 71266.89943098051 79896.59359167259 0.955209175426121 0.9854688694492878 1.0464743923129824 0.931633725552123 1.0993030993847093 0.9137773464402676 0.8047930250395126 1.0239907482475379 0.8919892103936766 1.0 16.285846374402787 TSQCSSPSLSAS(ph)PGS(ph)PTRPQIR ddPTM_A459_Selumetinib_30min_R2 1 TSQCSSPSLSASPGSPTRPQIR 22 1 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMD3;H0YND9 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 2 T(0.067)S(0.077)QCS(0.091)S(0.105)PS(0.18)LS(0.031)AS(0.451)PGS(0.977)PT(0.021)RPQIR 57.662 0.04111 5104100.0 19454.0 19331.0 17265.0 18416.0 21271.0 18049.0 13100.0 17315.0 16795.0 18751.0 True False 18372.824560532295 20813.625541038145 16154.188696710697 15907.709030628026 18598.74681484728 20535.085917491026 13709.175957157551 17365.38378334745 20154.469291508445 18209.60990905112 1.0089631053216603 1.1430022743481558 0.8871243688027182 0.8735886770820428 1.0213698650185108 1.1277059761331858 0.7528539065706937 0.9536384288339946 1.1068040112979372 1.0 14.152412396410854 -5.2594748613082585 24.998461329693225 0.9606575917544419 1.0759826859903736 0.13941700123156875 0.10940784878473733 325.5752608554579 4142861.033027405 0.028720295255631623 0.06862568809600314 5.502057676869113e-06 5.2594748613082585 0.11532509423593174 TSQCSSPSLSASPGS(ph)PTRPQIR ddPTM_A459_Selumetinib_30min_R1 1 TSQCSSPSLSASPGSPTRPQIR 22 1 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMD3;H0YND9 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 TSQCSSPSLSAS(0.037)PGS(0.727)PT(0.236)RPQIR 92.363 0.00017677 18184000.0 1324.9 1602.5 1763.4 1741.4 1607.4 1469.5 1391.3 1148.6 845.45 1280.3 True False 1355.7675921933728 1414.8785550179614 1523.9399656628482 1437.297180126493 1462.0109538095198 1454.7181641992454 1286.353120857943 1118.1353968213857 1434.6669007751307 1444.6389761780752 0.9384819422359628 0.9793994059063479 1.0548932922290184 0.9949179025537539 1.0120251342500837 1.0069769597715241 0.8904322409056885 0.7739894985939777 0.9930971851324913 1.0 10.496493284409826 -7.262039758645179 24.966152473573356 0.895545518007039 1.0000599860838357 0.26321408739726604 0.06532375954286411 58.61414783977717 2437323.4623923646 0.02549697328856536 0.018365150307782428 5.469658871527516e-08 7.262039758645179 0.10451446807679676 TSQCSSPSLSASPGS(ph)PTRPQIR ddPTM_A459_Selumetinib_30min_R2 1 TSQCSSPSLSASPGSPTRPQIR 22 1 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMD3;H0YND9 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 TSQCSSPSLS(0.001)AS(0.023)PGS(0.884)PT(0.091)RPQIR 74.277 0.0010876 1714800.0 3294.9 1084.4 2788.6 3740.6 2788.1 2312.8 5197.0 3900.3 2290.1 3417.0 True False 3111.782648529757 1167.5699931044328 2609.1845119981135 3231.1238271050834 2437.8339520697514 2631.36720649195 5438.670797660137 3911.649227270577 2748.183990740308 3318.342331567792 0.9377521477898746 0.35185338836117 0.7862915429721116 0.9737162427055858 0.7346541461013055 0.7929764151996723 1.6389721897953096 1.1787961688155513 0.8281797705428103 1.0 11.6962470119984 -7.038380931715038 24.82746333741242 1.1820422314718573 0.7496146089004185 0.3831472182743082 0.247498245721216 518.3681493368315 335315.08322027035 0.09565303225036875 0.07411010197803652 9.154172001068061e-08 7.038380931715038 -0.43242762257143874 TSQCSSPSLSASPGSPT(ph)RPQIR ddPTM_A459_Selumetinib_30min_R1 2 TSQCSSPSLSASPGSPTRPQIR 22 1 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMD3;H0YND9 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 TSQCSSPSLSAS(0.009)PGS(0.382)PT(0.609)RPQIR;TSQCSSPSLSASPGS(0.259)PT(0.741)RPQIR 118.44 4.5843e-05 33995000.0 1907.99 1909.45 2092.9 2289.4 1936.1 1793.7199999999998 1900.84 1670.5 1077.65 1511.27 True False 1952.4424546977398 1685.8907063207782 1808.6956754767912 1889.5992673605124 1760.9800968462184 1775.676805367453 1757.4581084249362 1626.1929134512668 1828.6933415581282 1705.2562255163948 1.1449554767680092 0.988643630848055 1.0606591833019534 1.1081028405501312 1.03267771171042 1.0412961869291713 1.0306123397337157 0.9536355235758277 1.0723862573815577 1.0 10.73577281423936 -6.91443415538148 1.542656573439905 1.0100715631494728 1.0670354715362773 0.23130241926397943 0.047100827365903854 0.613272034126573 2.996526432341847 0.021809436227711355 0.017447763340779583 1.217771608658316e-07 6.91443415538148 0.05696390838680454 TSQCSSPSLSASPGSPT(ph)RPQIR ddPTM_A459_Selumetinib_30min_R2 2 TSQCSSPSLSASPGSPTRPQIR 22 1 P37275-3;P37275-4;P37275-5;P37275;P37275-2;H0YMD3;H0YND9 P37275-3 ZEB1 Zinc finger E-box-binding homeobox 1 1 TSQCSSPSLSAS(0.001)PGS(0.194)PT(0.806)RPQIR;TSQCSSPSLSASPGS(0.159)PT(0.841)RPQIR 134.29 2.6351e-05 121617000.0 51519.0 55271.0 58708.0 55133.0 54141.0 40422.0 44853.0 38764.0 35403.0 44907.0 True False 48655.78022689745 59510.107975723986 54930.79119643739 47623.79029027017 47339.32355331888 45989.763585618144 46938.753374533386 38876.79682227434 42484.58924246939 43610.41822760168 1.1156916673663653 1.3645846656443932 1.2595795552740396 1.0920278278855937 1.0855049200917115 1.0545591043314173 1.0763197254738812 0.89145663816791 0.9741844029273781 1.0 15.412385205602853 -6.338749644918321 0.8181791424347683 0.9693087198797767 1.2674109299514063 0.6570650338537629 0.07572118985898292 0.3890449516865888 0.5677656658990103 0.04283686759400762 0.06599957456511278 4.584060651010273e-07 6.338749644918321 0.2981022100716295 TSQEELLAEVVQGQS(ph)RTPR ddPTM_A459_Selumetinib_30min_R1 1 TSQEELLAEVVQGQSRTPR 19 1 Q6PJT7-5;Q6PJT7;G3V256;Q6PJT7-10;Q6PJT7-4;G3V5I6;A0A087WTC9;Q6PJT7-9;Q6PJT7-2;H0YJA2;Q6PJT7-3;Q6PJT7-11 Q6PJT7-5;Q6PJT7-9 ZC3H14 Zinc finger CCCH domain-containing protein 14 1 TSQEELLAEVVQGQS(0.5)RT(0.5)PR 102.92 0.00057541 6599900.0 4350.7 5817.4 4475.8 4316.3 4344.9 4609.4 5731.3 4909.2 3205.1 5606.4 True False 4452.062845011478 5136.296103564114 3868.0109438095596 3562.5392319857515 3951.904562154397 4563.033621000341 5298.9834267039 4778.992068671032 5438.820608757906 6326.036050960532 0.7037681747538392 0.8119296289473769 0.6114430763040386 0.5631550631844444 0.6247047171908463 0.7213100880617808 0.8376467323323764 0.755448124255536 0.8597517568576117 1.0 12.62708606220468 -8.222919570513119 0.7015863387299672 0.9926243324964121 0.666746656723764 0.6688575418952549 0.07252700625473721 0.44984167441518147 0.4937523602090015 0.07894844556530038 0.03353167940854644 5.985224285996462e-09 8.222919570513119 -0.32587767577264815 TSQLGDS(ph)PFYPGK ddPTM_A459_Selumetinib_30min_R1 2 TSQLGDSPFYPGK 13 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 T(0.056)S(0.041)QLGDS(0.902)PFY(0.001)PGK;T(0.074)S(0.002)QLGDS(0.924)PFYPGK 122.96 0.0025464000000000003 29826000.0 7459.0 7319.200000000001 8603.5 8615.9 7440.7 6360.1 7633.700000000001 6247.9 4219.3 5370.299999999999 True False 7632.780187312531 6462.264661396232 7435.191955642688 7111.294805473675 6767.689998762282 6296.123168508757 7057.883863072873 6082.1853959605905 7159.8439345206725 6059.630316151778 1.2596115256350813 1.0664453645251664 1.2270042177035765 1.173552582328119 1.1168486600120127 1.0390276039986488 1.1647383577609145 1.003722187432572 1.1815644785188142 1.0 12.56501406560072 -6.39077401704388 3.5596291553297656 1.0830326599673354 1.1767250340304092 0.3073587510420135 0.07295864607079706 0.326925045147174 7.5307837514896505 0.02202382963042481 0.025148490317417102 4.0665487494727104e-07 6.39077401704388 0.09369237406307374 TSQLGDS(ph)PFYPGK ddPTM_A459_Selumetinib_30min_R2 2 TSQLGDSPFYPGK 13 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 T(0.057)S(0.04)QLGDS(0.903)PFYPGK;TSQLGDS(1)PFYPGK 164.63 0.00036265 36232000.0 196187.0 200821.0 195559.0 226778.0 215583.0 176765.0 198334.0 171349.0 148117.0 195648.0 True False 185283.7119387864 216223.32495870977 182976.94684854045 195890.44518612922 188499.5362035267 201112.77423709366 207556.9239913651 171847.59722164617 177744.5387347633 189999.1338854475 0.9751818766210584 1.1380226874564234 0.9630409523806525 1.0310070429280676 0.9921073446428186 1.0584931105967395 1.0924098428601436 0.9044651610109703 0.9355018367711475 1.0 17.5356333164561 -7.769165722323415 24.99998411337289 0.9399876168566256 1.0359022981211279 0.35570246804181327 0.05472951710299861 181.4831863898238 587210.5302575611 0.02815924043397596 0.013920428108208078 1.7015091060632822e-08 7.769165722323415 0.09591468126450231 TSQLT(ph)PQR ddPTM_A459_Selumetinib_30min_R2 1 TSQLTPQR 8 0 E9PIM8;E9PKW0;E9PMR8;E9PRT0;E9PSB9;E9PR06;A0A5F9ZH13;Q9NQC8;Q9NQC8-2 E9PIM8 IFT46 Intraflagellar transport protein 46 homolog 1 T(0.055)S(0.001)QLT(0.944)PQR 97.163 0.047922 12300000.0 52504.0 41690.0 51360.0 54184.0 58629.0 45440.0 51493.0 58050.0 45764.0 48619.0 True False 49586.03787016486 44887.48894552172 48055.5535165399 46804.04572738646 51263.50087008983 51698.947536749525 53887.52653144378 58218.91588930517 54918.07875299743 47215.2431426674 1.050212485835004 0.9506990954147573 1.0177974382411499 0.9912910029068694 1.0857404824791448 1.0949630690354382 1.1413162983957352 1.2330533957728154 1.1631429830204378 1.0 15.526965079307981 -6.615622813111601 1.4797335476719566 1.1509962719737914 0.997524405346122 0.4705302208128138 0.06069804176052448 0.29916888269666125 1.355834040412301 0.024953803490396012 0.025551128403613333 2.423132635698486e-07 6.615622813111601 -0.15347186662766943 TSQVGAASAPAKES(ph)PR ddPTM_A459_Selumetinib_30min_R1 7 TSQVGAASAPAKESPR 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 TSQVGAASAPAKES(1)PR;TSQVGAASAPAKES(1)PR;TSQVGAASAPAKES(1)PR;T(0.001)S(0.003)QVGAAS(0.001)APAKES(0.995)PR;TSQVGAASAPAKES(1)PR;TSQVGAASAPAKES(1)PR;TSQVGAAS(0.011)APAKES(0.989)PR 263.19 1.1153999999999998e-38 1791944600.0 30924.190000000002 36426.50000000001 37762.21 41750.0 32127.0 31860.260000000002 32410.0 31148.67 18571.77 27535.56 True False 31644.663459000985 32161.66844577959 32634.309294971776 34459.14624456248 29221.118522482524 31539.774711201524 29965.287606559305 30322.50608646039 31514.937261586772 31070.01734506754 1.018495197719118 1.035135194441253 1.0503473149863745 1.109080367154445 0.9404925075499343 1.0151193145763904 0.9644438647639308 0.9759410736625862 1.0143199120740067 1.0 14.92323542640463 -6.268483718155277 24.99981284938838 0.9843227149521835 1.051761195507128 0.549333249703565 0.030250765982282383 433.5392955349891 1538594.9302182705 0.009285377978754925 0.01073509792755733 5.38910048911727e-07 6.268483718155277 0.0674384805549445 TSQVGAASAPAKES(ph)PR ddPTM_A459_Selumetinib_30min_R2 6 TSQVGAASAPAKESPR 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 TSQVGAASAPAKES(0.999)PR;TSQVGAASAPAKES(1)PR;TSQVGAAS(0.008)APAKES(0.992)PR;T(0.001)S(0.003)QVGAAS(0.076)APAKES(0.92)PR;T(0.005)S(0.002)QVGAAS(0.001)APAKES(0.992)PR;TSQVGAASAPAKES(1)PR 126.43 0.0015432 1085998700.0 653764.0 626201.0 684226.0 687346.0 706262.0 573097.0 582496.0 591241.0 471558.0 741845.0 True False 617430.4141046487 674228.6031464312 640203.6440889407 593728.2890620152 617535.0534976098 652035.9096934097 609583.2181939271 592961.4134247829 565882.7764313868 720426.0073052126 0.8570351539836496 0.935874880014972 0.8886459367057731 0.8241350021258725 0.8571804005348569 0.9050699212433776 0.8461427155775537 0.8230705268994702 0.7854835481968482 1.0 19.45849073776457 -5.543013529506304 21.70355441530921 0.8564419000385772 0.9004063566401519 0.048542665328029644 0.05780292419415408 114.47136325035976 123388.43025726003 0.015036911057451474 0.026054397494173185 2.8640887440197237e-06 5.543013529506304 0.043964456601574664 TSQVGAASAPAKES(ph)PRK ddPTM_A459_Selumetinib_30min_R2 2 TSQVGAASAPAKESPRK 17 2 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 TSQVGAASAPAKES(0.999)PRK;TSQVGAASAPAKES(1)PRK 66.868 0.020512 41278400.0 187430.0 168220.0 193394.0 199842.0 178373.0 151361.0 167900.0 154260.0 127041.0 199217.0 True False 177013.39094173774 181121.93308744684 180951.24059146646 172623.1748533216 155964.18906514774 172209.6038316449 175707.68268753836 154708.87106088237 152452.74982212103 193465.08758207268 0.9149629690506526 0.9361995766321943 0.9353172856818545 0.8922704194889457 0.8061619334753816 0.8901327158502917 0.9082139050695583 0.7996733312166777 0.7880116858678535 1.0 17.561713717723293 -5.9767118396462715 5.175655331475628 0.8578421300836735 0.9281560781151392 0.18036236597337874 0.059196287170683065 0.2755852864424931 20.523461607203433 0.01678145600346548 0.024529607811331025 1.055086728727408e-06 5.9767118396462715 0.07031394803146573 TSQVGAASAPAKESPR ddPTM_A459_Selumetinib_30min_R1 1 TSQVGAASAPAKESPR 16 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 0 115.58 0.0056037 3555400.0 527.07 766.2 802.91 658.49 776.25 672.01 643.09 790.23 371.41 615.1 False True 539.3497055003103 676.4929478032838 693.8792320689333 543.4970828881908 706.0383245580687 665.2501895362607 594.5812035452706 769.270533371203 630.2556432868785 694.0540765813752 0.7771004071569251 0.9746977514135637 0.9997480822916522 0.7830759896480024 1.0172670233935128 0.958499073750866 0.8566784975515639 1.1083726172466462 0.9080785842959939 1.0 9.438904263207117 -4.757457187198629 24.990341018466037 0.9544654479461401 0.7771001493450526 0.28259581781070886 0.08559752608650827 154.7498534485632 971002.0761481399 0.02050059956630193 0.152436207625988 1.7480055725209043e-05 4.757457187198629 -0.17736529860108752 TSRPENAIIYNNNEDFQVGQAK ddPTM_A459_Selumetinib_30min_R2 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 173.03 8.6107e-12 7364700.0 29812.0 22042.0 26974.0 29629.0 31221.0 22724.0 25002.0 26849.0 17916.0 24057.0 False True 28155.168386891575 23732.550523799233 25238.522207070604 25593.479087124113 27298.73886071866 25854.024732066362 26164.642540523146 26927.126144908772 21499.70061486545 23362.4119024075 1.2051481886589877 1.0158433394179471 1.0803046497296698 1.0954981529320054 1.1684897507481031 1.1066504965355097 1.119946118997537 1.1525833144879158 0.9202688791155977 1.0 14.511901603254524 -8.261148900469747 24.999928365051296 0.9601344289216033 1.1140041529256133 0.5943423395703609 0.05210168639754402 17.517241673545684 1507985.4714864583 0.03997114246280517 0.012939496270795046 5.480890170940448e-09 8.261148900469747 0.15386972400401 TSS(ph)AELSTSAPDEPLLQK ddPTM_A459_Selumetinib_30min_R1 4 TSSAELSTSAPDEPLLQK 18 0 Q15139 Q15139 PRKD1 Serine/threonine-protein kinase D1 1 T(0.004)S(0.03)S(0.966)AELSTSAPDEPLLQK;T(0.059)S(0.286)S(0.656)AELSTSAPDEPLLQK;T(0.264)S(0.038)S(0.422)AELS(0.078)T(0.184)S(0.013)APDEPLLQK;T(0.087)S(0.015)S(0.896)AELS(0.001)T(0.001)SAPDEPLLQK 228.49 9.9245e-19 20311100.0 4338.469999999999 5491.12 5649.27 5963.63 6082.7 4193.96 5460.110000000001 5238.700000000001 2506.31 4305.83 True False 4439.547909806918 4848.217117647568 4882.130163218868 4922.193971699647 5532.520858987911 4151.772570211002 5048.249506740222 5099.7526583041945 4253.025016360184 4858.525222835929 0.9137645079910787 0.9978783468819075 1.0048584579271076 1.013104542210559 1.1387243258477044 0.8545335013795824 1.0390497682326636 1.0496503412876101 0.8753736620261254 1.0 12.246302743228364 -4.761529487935479 6.213836416502325 1.0007914824936672 0.9109030170463179 0.09230794801836684 0.07756685776374003 0.31147090655761217 50.47605050307566 0.018604764071992942 0.1190008291768195 1.731691447540044e-05 4.761529487935479 -0.0898884654473493 TSS(ph)AELSTSAPDEPLLQK ddPTM_A459_Selumetinib_30min_R2 2 TSSAELSTSAPDEPLLQK 18 0 Q15139 Q15139 PRKD1 Serine/threonine-protein kinase D1 1 T(0.318)S(0.047)S(0.635)AELSTSAPDEPLLQK;T(0.098)S(0.02)S(0.499)AELS(0.362)T(0.021)SAPDEPLLQK 328.34 4.384599999999997e-144 11392700.0 72385.0 48790.0 66583.0 61298.0 66319.0 39564.0 55805.0 65518.0 39497.0 48003.0 True False 68362.13148011363 52532.03611542353 62299.12227008905 52949.10665505196 57987.41432061753 45013.581873766685 58400.043075509675 65708.64653291121 47397.50363838697 46617.028663227655 1.4664626519630348 1.1268851237801378 1.336402684953443 1.1358318660240816 1.2439105619436237 0.9656038397246499 1.252762021736848 1.4095417150588014 1.0167422720310564 1.0 15.508569430574786 -1.522878749230029 0.02331243810598894 4.133327700342857e-08 2.799798210110588 0.24664784486330948 0.14419761317941282 3914.8941077954546 7.04944052842672 298.8318705636342 594.4427749436966 0.029999999727164977 1.522878749230029 2.7997981687773112 TSS(ph)DPNLNNHCQEVR ddPTM_A459_Selumetinib_30min_R1 2 TSSDPNLNNHCQEVR 15 0 J3QR65;Q9NYA4 J3QR65 MTMR4 Myotubularin-related protein 4 1 T(0.026)S(0.026)S(0.948)DPNLNNHCQEVR;T(0.102)S(0.102)S(0.796)DPNLNNHCQEVR 176.85 1.2793e-05 11398800.0 4320.3 4377.4 5173.5 5383.799999999999 5204.8 4570.6 4625.9 5314.0 2192.5 3894.0 True False 4420.954584159584 3864.891973001952 4470.9671160013295 4443.6203964425285 4734.026758982076 4524.623913772761 4276.964638666541 5173.055457695322 3720.512366135754 4393.8328307720285 1.00617268667975 0.8796174369526166 1.017555125149299 1.0113312380302262 1.0774253234732813 1.0297669683936863 0.9734017663833258 1.177344623005691 0.8467578329515173 1.0 12.101264266211164 -5.401524764909713 8.583353496903161 1.0244201907569543 0.9431018563762656 0.10692156818629772 0.0831687203523268 0.5479308968494134 36.111785422323734 0.02016506427022495 0.04208666838840256 3.967119064598668e-06 5.401524764909713 -0.0813183343806887 TSS(ph)DPNLNNHCQEVR ddPTM_A459_Selumetinib_30min_R2 1 TSSDPNLNNHCQEVR 15 0 J3QR65;Q9NYA4 J3QR65 MTMR4 Myotubularin-related protein 4 1 T(0.175)S(0.175)S(0.65)DPNLNNHCQEVR 90.755 0.01008 9732200.0 24661.0 16534.0 25469.0 24059.0 36562.0 21985.0 19612.0 19964.0 18654.0 24024.0 True False 23290.44034580481 17802.104634810654 23830.35226855051 20782.122695910068 31968.754691572838 25013.23419004043 20523.99686044074 20022.09193478189 22385.321236308348 23330.364698151778 0.9982887386089542 0.7630444215139478 1.0214307653081112 0.8907757321751777 1.3702638216412188 1.0721321553975525 0.8797117887345604 0.8581988406022659 0.9594929837544162 1.0 14.509921239126282 -4.395620355902214 21.682433027672587 0.9793823224384751 11.860221337120556 0.0013111738747146884 0.15596553807715846 13207.628050136665 2265989.832047877 0.040068705599569376 49814.71146886306 4.021421950064308e-05 4.395620355902214 10.880839014682081 TSS(ph)DPVLLK ddPTM_A459_Selumetinib_30min_R1 1 TSSDPVLLK 9 0 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 T(0.122)S(0.017)S(0.861)DPVLLK 164.66 0.00097838 17304000.0 5746.7 6705.0 7123.5 7424.3 6155.2 5818.3 5975.9 6082.1 3235.7 5253.8 True False 5880.586928868335 5919.9754829300655 6156.167826584611 6127.785376371388 5598.463246788819 5759.773184593719 5525.133051775307 5920.782950554898 5490.746573822332 5928.176406345682 0.9919723243346122 0.9986166195380356 1.038458946666108 1.0336712264183028 0.9443820262831704 0.9715927445121741 0.9320122535255619 0.9987528279720438 0.9262117382244035 1.0 12.533372663610395 -6.262010552909365 24.999812742266066 0.9610606292310518 1.0160880663061262 0.4923343257054471 0.026609728284743735 43.87056386342236 1920168.7774740786 0.007808228867576727 0.00937912986849075 5.470026711300089e-07 6.262010552909365 0.055027437075074404 TSS(ph)DPVLLK ddPTM_A459_Selumetinib_30min_R2 1 TSSDPVLLK 9 0 Q9BRG2;Q9BRG2-2 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 T(0.001)S(0.005)S(0.995)DPVLLK 160.77 0.00091312 31321000.0 189800.0 198330.0 200190.0 220100.0 208850.0 162180.0 179000.0 199450.0 138560.0 192630.0 True False 179251.67582959952 213541.27326853762 187309.99335039183 190122.00030632186 182612.39585731053 184518.8228765413 187323.85468177107 200030.36647927508 166275.87168987285 187068.27138715336 0.9582152788412913 1.1415151895352482 1.001292159068163 1.0163241414298876 0.9761804848208544 0.9863715610792395 1.0013662567827377 1.0692907193507744 0.8888512758304752 1.0 17.513205358541384 -5.485844395645449 24.913466676853385 0.9948453017361695 1.055249859464384 0.13093654007757727 0.05880891491569783 945.5319592033774 636069.4354878095 0.014287882613064823 0.029727294915946872 3.267048670322535e-06 5.485844395645449 0.060404557728214514 TSS(ph)EASMDAAYLDK ddPTM_A459_Selumetinib_30min_R1 2 TSSEASMDAAYLDK 14 0 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 T(0.009)S(0.004)S(0.987)EASMDAAYLDK;T(0.007)S(0.001)S(0.992)EASMDAAYLDK 312.67 4.0362999999999987e-94 35729000.0 4883.4 6527.3 4700.6 4455.1 4809.2 4777.1 4992.5 4984.700000000001 3296.6000000000004 4664.0 True False 4997.1737185577185 5763.080681540554 4062.2843385475717 3677.100417584442 4374.208709133223 4729.046711259757 4615.911705515192 4852.4895634124705 5594.0894258623175 5262.669831207176 0.949551060361969 1.0950868791665374 0.7719056047291012 0.6987138725252258 0.8311767314746871 0.8986022043824449 0.8771045597698788 0.922058521444311 1.0629755628388184 1.0 12.361579170691366 -8.08036230414816 3.395217924668266 1.030273255070461 0.8722409344653062 0.2744993158291328 0.10027690072126637 0.3744740460233322 7.948852759354243 0.08609137314047545 0.02958339377765786 8.310701730651212e-09 8.08036230414816 -0.15803232060515482 TSS(ph)EASMDAAYLDK ddPTM_A459_Selumetinib_30min_R2 1 TSSEASMDAAYLDK 14 0 Q5W0B1 Q5W0B1 RNF219 RING finger protein 219 1 T(0.031)S(0.004)S(0.965)EASMDAAYLDK 295.44 2.9230999999999993e-67 7976300.0 36574.0 39395.0 45134.0 44168.0 52013.0 40116.0 39494.0 42797.0 31145.0 45536.0 True False 34541.3634973223 42416.469825109816 42230.12757818361 38152.24220595018 45478.66193788029 45641.614863209565 41330.549255876336 42921.53218457527 37374.870264008976 44221.25736326341 0.7811031516715164 0.959187331031141 0.954973469688496 0.8627579693752662 1.0284343921812922 1.0321193377266136 0.9346308024749085 0.9706085883535307 0.8451788233198897 1.0 15.432452426095615 -4.760516871172135 24.898601309329045 0.9545999073883354 0.7811029398110539 0.4379766644967734 0.0588269543716572 21.047610762158595 567754.598599547 0.014723700301000129 0.08683962828126536 1.7357338329723737e-05 4.760516871172135 -0.1734969675772815 TSS(ph)EDNLYLAVLR ddPTM_A459_Selumetinib_30min_R1 9 TSSEDNLYLAVLR 13 0 Q15149-4 Q15149-4 PLEC Plectin 1 T(0.223)S(0.03)S(0.747)EDNLYLAVLR;T(0.006)S(0.006)S(0.987)EDNLYLAVLR;T(0.06)S(0.181)S(0.76)EDNLYLAVLR;T(0.068)S(0.068)S(0.864)EDNLYLAVLR;T(0.065)S(0.438)S(0.496)EDNLYLAVLR;T(0.302)S(0.042)S(0.656)EDNLYLAVLR;T(0.148)S(0.027)S(0.824)EDNLYLAVLR;T(0.143)S(0.025)S(0.831)EDNLYLAVLR;T(0.058)S(0.008)S(0.934)EDNLYLAVLR 293.53 6.872599999999998e-61 5215342100.0 39704.700000000004 47111.6 47124.6 48034.09999999999 41255.259999999995 39045.5 41948.9 38904.19 25220.390000000003 36581.200000000004 True False 40629.742258102655 41595.751970411366 40725.338156898855 39645.84614672907 37523.72901720772 38652.73772047746 38784.66069974685 37872.32450258107 42797.159805594725 41276.75335106257 0.9843250488366411 1.0077282875577853 0.9866410231087247 0.9604884814834518 0.9090765617650439 0.9364287300343702 0.9396247900090337 0.917521884060829 1.0368344487174403 1.0 15.333041878689366 -5.766334677380923 3.5778881561938842 0.9495034246509304 0.9958234629382917 0.15206373159024789 0.03664026977877866 0.33453446666713993 9.094130611671527 0.010270887262551 0.01739255852779759 1.7126370011267716e-06 5.766334677380923 0.04632003828736131 TSS(ph)EDNLYLAVLR ddPTM_A459_Selumetinib_30min_R2 9 TSSEDNLYLAVLR 13 0 Q15149-4 Q15149-4 PLEC Plectin 1 T(0.127)S(0.019)S(0.853)EDNLYLAVLR;T(0.012)S(0.002)S(0.986)EDNLYLAVLR;T(0.224)S(0.224)S(0.553)EDNLYLAVLR;T(0.026)S(0.028)S(0.946)EDNLYLAVLR;TS(0.002)S(0.998)EDNLYLAVLR;T(0.057)S(0.304)S(0.64)EDNLYLAVLR;T(0.046)S(0.06)S(0.894)EDNLYLAVLR;T(0.029)S(0.011)S(0.959)EDNLYLAVLR;TS(0.002)S(0.998)EDNLYLAVLR 260.73 9.7872e-30 470515700.0 2041914.9 1851568.7 1848319.8 2084928.8 2003098.0 1564145.3 1777660.8 1802505.5999999999 1481873.0 1832548.3 True False 1928433.4442909868 1993578.0655582608 1729400.9163664386 1800957.9007372127 1751450.9213166723 1779592.1171776683 1860325.5495680494 1807750.5928751354 1778289.0069910954 1779637.8690467032 1.0836100297888067 1.120215578816694 0.9717712498963764 1.0119799831534997 0.9841614138357655 0.9999742914725346 1.045339381637551 1.0157968788579956 0.9992420581293145 1.0 20.76315227249232 -5.2560139684074665 24.99790160489668 1.0050731323653974 1.1019128121776183 0.7910219199667401 0.020214132876279895 192.09687727869843 885089.346122188 0.005326759876753977 0.013273716982283013 5.546078745701688e-06 5.2560139684074665 0.09683967981222086 TSS(ph)EEEDSRREEPSLLLVLK ddPTM_A459_Selumetinib_30min_R1 1 TSSEEEDSRREEPSLLLVLK 20 2 A0A087WZV0;O43314;O43314-2;D6RBU4 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 T(0.147)S(0.147)S(0.676)EEEDS(0.029)RREEPS(0.002)LLLVLK 56.29 0.016438 4750700.0 1819.0 2399.9 2376.6 2689.5 2040.2 1979.8 1648.7 1547.9 1150.6 1540.8 True False 1861.379160842135 2118.9185923167593 2053.870773729343 2219.829313167685 1855.664270226566 1959.8850095145735 1524.3372316240157 1506.8446637121915 1952.4841635009345 1738.5766886629533 1.0706339116243544 1.2187662506543249 1.1813518420685059 1.276808395995944 1.0673468028917714 1.1272928150335528 0.8767730762548658 0.8667116461057726 1.123035973180157 1.0 10.763690990446966 -6.9501829837285936 2.1528431819116656 0.9587613256135532 1.1792933479312575 0.5027308079146174 0.09079603429717319 0.24267743633352856 2.2770897473542524 0.03804504971383117 0.030855268963744527 1.121545807555335e-07 6.9501829837285936 0.2205320223177043 TSS(ph)FAEPGGGGGGGGGGPGGSASGPGGTGGGK ddPTM_A459_Selumetinib_30min_R1 4 TSSFAEPGGGGGGGGGGPGGSASGPGGTGGGK 32 0 P49840 P49840 GSK3A Glycogen synthase kinase-3 alpha 1 T(0.154)S(0.154)S(0.691)FAEPGGGGGGGGGGPGGSASGPGGTGGGK;T(0.154)S(0.154)S(0.692)FAEPGGGGGGGGGGPGGSASGPGGTGGGK;T(0.176)S(0.176)S(0.648)FAEPGGGGGGGGGGPGGSASGPGGTGGGK;T(0.176)S(0.176)S(0.649)FAEPGGGGGGGGGGPGGSASGPGGTGGGK 193.73 3.0168e-41 92886000.0 27593.100000000002 33883.7 33750.4 36066.8 27959.5 32157.5 31017.4 27441.699999999997 17078.1 24152.199999999997 True False 28235.96554317379 29916.58065189524 29167.281057676846 29768.410437685903 25430.568161650644 31834.02474667388 28677.73254574801 26713.856972795937 28980.288364927244 27252.370132350323 1.0360921052387981 1.0977606904135773 1.0702658490262247 1.092323724252845 0.933150696183409 1.1681194917019286 1.0523023284387911 0.9802397678829726 1.0634043286578503 1.0 14.734094085750664 -7.539209095111019 23.861596271387523 1.0163473875612858 1.066960849248823 0.13433730885045714 0.05871906761452375 294.6568351049632 430538.25090196833 0.02674589322093799 0.015448371105891869 2.889288472674703e-08 7.539209095111019 0.05061346168753711 TSS(ph)FHLLR ddPTM_A459_Selumetinib_30min_R2 1 TSSFHLLR 8 0 Q9ULL5;Q9ULL5-2;A0A3Q5ADB5 Q9ULL5 PRR12 Proline-rich protein 12 1 TS(0.379)S(0.62)FHLLR 109.29 0.0082772 2506000.0 11784.0 12378.0 18815.0 19927.0 22972.0 13652.0 9069.7 12100.0 11007.0 22287.0 True False 11129.092455089569 13327.352798456895 17604.463384223087 17212.908224007635 20086.051987714345 15532.43907948292 9491.459021269604 12135.208996737172 13208.70756127618 21643.516401419794 0.514199830040534 0.615766521080772 0.8133827728228233 0.7952916663245388 0.9280401398359057 0.7176485923730954 0.43853590355802685 0.560685646993162 0.6102847299069065 1.0 14.401647291041227 -7.025200453192486 24.516091759338963 0.6103849131989888 0.743508633818727 0.024414803715095412 0.17155709090642718 1354.9427299630531 1318142.6428837425 0.06573384535283806 0.051160709271538436 9.436252355898211e-08 7.025200453192486 0.1331237206197382 TSS(ph)FTEQLDEGTPNR ddPTM_A459_Selumetinib_30min_R1 3 TSSFTEQLDEGTPNR 15 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71;C9J0Y3;C9JHJ5 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 T(0.001)S(0.002)S(0.93)FT(0.068)EQLDEGTPNR;T(0.203)S(0.032)S(0.383)FT(0.383)EQLDEGTPNR;TS(0.016)S(0.635)FT(0.349)EQLDEGTPNR 312.38 1.1036999999999996e-94 317542000.0 10502.3 12654.4 9322.900000000001 10437.5 11074.1 10284.900000000001 12077.4 10428.0 6325.1 10431.3 True False 10746.98315608156 11172.816965129037 8056.901387024023 8614.78656114062 10072.449610291156 10181.443243942034 11166.391994429474 10151.415565082201 10733.232732973891 11770.25896446643 0.9130625917854428 0.9492413887289118 0.6845135193156949 0.731911386754365 0.8557542905979522 0.865014378585814 0.9486955238741996 0.8624632300553964 0.9118943572419904 1.0 13.52285844186646 -6.904974757992021 2.4163219532973925 0.9188675746485833 0.8189818480443118 0.2681523349053039 0.07965127383606119 0.475851448611629 5.64722964772716 0.034949293762889924 0.029540784555914128 1.2445869473915882e-07 6.904974757992021 -0.09988572660427142 TSS(ph)GLGGSTTDFLEEWK ddPTM_A459_Selumetinib_30min_R1 1 TSSGLGGSTTDFLEEWK 17 0 Q96IZ0;A0A0B4J260;F8W1M8 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 T(0.219)S(0.219)S(0.56)GLGGSTTDFLEEWK 95.662 0.0063045 5210200.0 1275.8 1351.6 1452.1 1409.4 1101.3 1545.1 1292.7 1001.7 771.21 1123.9 True False 1305.5236577253424 1193.3540436582077 1254.9127958143488 1163.2747477146443 1001.6876094503073 1529.5576968385533 1195.1905982412588 975.1316620198347 1308.6870430501958 1268.1635127130664 1.0294600377930359 0.9410096030165591 0.9895512552081163 0.9172908194038585 0.7898725987686954 1.2061202530313058 0.9424578031616035 0.7689321229039864 1.0319544995033287 1.0 10.30852505835045 -7.521927059552624 24.99962591198732 0.9114049952143201 0.975259000056963 0.02089462095412331 0.11748198386306942 121.01931768529656 3179306.306453857 0.05400655034322699 0.03169208952214709 3.006581220312988e-08 7.521927059552624 0.06385400484264292 TSS(ph)GLGGSTTDFLEEWK ddPTM_A459_Selumetinib_30min_R2 3 TSSGLGGSTTDFLEEWK 17 0 Q96IZ0;A0A0B4J260;F8W1M8 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 T(0.211)S(0.043)S(0.746)GLGGSTTDFLEEWK;T(0.156)S(0.152)S(0.692)GLGGSTTDFLEEWK;T(0.145)S(0.262)S(0.593)GLGGSTTDFLEEWK 148.52 0.00038789 0.0 13293.900000000001 13155.8 12373.3 17298.0 15332.699999999999 11389.9 14252.1 11554.2 9726.2 14615.8 True False 12555.078257698178 14164.807557435714 11577.215349030434 14941.982559285592 13406.469149922843 12958.7553377822 14914.850890000389 11587.820809099216 11671.711772734106 14193.803877591025 0.8845464095442348 0.9979571142165005 0.815652762914977 1.0527116401034526 0.9445296881330583 0.9129867827919829 1.0508001250847028 0.8163999523337012 0.8223103456545034 1.0 13.792973656750101 -10.388517031098456 4.2520164967920495 1.0000010369443126 0.9260212512436992 0.06721339477509758 0.08601255546436705 40781139.15529185 64449656.52596997 626.7744457089963 0.021211455414397277 4.0877372150908434e-11 10.388517031098456 -0.07397978570061348 TSS(ph)GTSLSAMHSSGSSGK ddPTM_A459_Selumetinib_30min_R1 1 TSSGTSLSAMHSSGSSGK 18 0 A6NNK5;Q12888;Q12888-3;Q12888-2;M0R142 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.001)S(0.006)S(0.983)GT(0.009)SLSAMHSSGSSGK 178.22 1.8502e-09 1804900.0 518.89 764.33 452.02 642.38 1349.8 590.0 857.95 585.58 124.2 173.27 True False 530.9791274158198 674.8418882726229 390.63816676813 530.2003919660373 1227.7108283265454 584.0651356771386 793.234140760492 570.0485161680892 210.75832879090555 195.5108922927245 2.7158544528599595 3.451684355581736 1.9980378698454069 2.7118713732440343 6.279500921556747 2.98737900905623 4.057237586399223 2.915686739921356 1.0779876574618266 1.0 7.611105174897907 -6.088085876871429 22.91321627128058 3.313848890183805 2.7193829725018577 0.0 1.4499171066122802 144.70326346454902 37632.26370515992 0.4328823194773936 0.558849254527629 8.164209173005163e-07 6.088085876871429 -0.5944659176819473 TSS(ph)GTSLSAMHSSGSSGK ddPTM_A459_Selumetinib_30min_R2 2 TSSGTSLSAMHSSGSSGK 18 0 A6NNK5;Q12888;Q12888-3;Q12888-2;M0R142 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.172)S(0.172)S(0.554)GT(0.045)S(0.045)LS(0.013)AMHSSGSSGK;T(0.103)S(0.103)S(0.481)GT(0.156)S(0.156)LS(0.001)AMHSSGSSGK 95.622 0.0026171 9636000.0 25929.0 26965.0 59261.0 91231.0 119870.0 49548.0 35297.0 46088.0 53430.0 69002.0 True False 24487.969982010985 29033.128793859283 55448.21177849821 78805.18041774692 104810.8589486034 56372.787248038374 36938.380439678636 46222.108449720865 64117.49295893398 67009.73297127322 0.36543900260741036 0.43326734052657184 0.82746504604441 1.176025883456816 1.5641139622737397 0.8412626755609539 0.5512390335223983 0.6897820122568774 0.956838508615172 1.0 16.032083037650914 -5.306533051193282 3.4515192817268274 0.959722359695933 0.38157480247909215 0.42823791259212896 0.259001835128614 0.25377569283395607 6.1640916858582955 0.08000746455132214 0.204421416995605 4.937043443469216e-06 5.306533051193282 -0.5781475572168409 TSS(ph)IADEGTYTLDSILR ddPTM_A459_Selumetinib_30min_R1 3 TSSIADEGTYTLDSILR 17 0 A0A087WY00;G3V394;F8WE88;F8W6H6;Q9Y4I1-2;Q9Y4I1;Q9Y4I1-3;E7ERV5 A0A087WY00 MYO5A Unconventional myosin-Va 1 T(0.007)S(0.001)S(0.992)IADEGTYTLDSILR;T(0.047)S(0.035)S(0.918)IADEGTYTLDSILR;T(0.033)S(0.033)S(0.933)IADEGTYTLDSILR 381.02 9.237499999999992e-248 72817300.0 2343.64 3218.0299999999997 2604.0 2353.23 2558.6400000000003 2697.68 3459.267 3696.6699999999996 2089.1 2411.9 True False 2398.2422520704017 2841.2615515784387 2250.391102748131 1942.2825560980077 2327.211463764583 2670.543788497462 3198.331705118162 3598.622303123554 3545.0501181729537 2721.490858895495 0.8812237028948603 1.0440092210089407 0.8268964400128253 0.7136832922842425 0.8551237481315928 0.9812797201829627 1.1752130986088232 1.3222981408741674 1.302613274112446 1.0 11.410181474923776 -7.1767021591959805 2.4960798561159394 1.2362551826801382 0.8655009341174267 0.6637114568115341 0.1122124479604587 0.1751757971138659 2.1340859893398028 0.052258662735015816 0.03699410287185932 6.657295595409388e-08 7.1767021591959805 -0.37075424856271155 TSS(ph)IADEGTYTLDSILR ddPTM_A459_Selumetinib_30min_R2 3 TSSIADEGTYTLDSILR 17 0 A0A087WY00;G3V394;F8WE88;F8W6H6;Q9Y4I1-2;Q9Y4I1;Q9Y4I1-3;E7ERV5 A0A087WY00 MYO5A Unconventional myosin-Va 1 T(0.002)S(0.066)S(0.933)IADEGTYTLDSILR;TS(0.083)S(0.917)IADEGTYTLDSILR;T(0.007)S(0.023)S(0.97)IADEGTYTLDSILR 246.75 2.4202e-30 20736100.0 42988.0 28024.6 42726.0 45734.0 43523.0 33410.0 43776.0 48972.0 39730.0 51652.0 True False 40598.89905459867 30173.9967067083 39977.05567655144 39504.95030444952 38055.25163944326 38011.92423421659 45811.67074049837 49114.50041224897 47677.11014895092 50160.67255198703 0.8093770874487689 0.6015468926465383 0.796980057137767 0.7875681942562909 0.7586670932293105 0.7578033208151395 0.9132985745559669 0.9791435782952512 0.9504878567873641 1.0 15.614269071407735 -7.354267942735524 2.5481932564707614 0.9736777812102942 0.7464260624359581 0.7767730060991977 0.055523923075542596 0.13712247697175745 1.7371841539189008 0.027361571655791454 0.016994778650915053 4.4231539683685526e-08 7.354267942735524 -0.22725171877433614 TSS(ph)LDTITGPYLTGQWPR ddPTM_A459_Selumetinib_30min_R2 1 TSSLDTITGPYLTGQWPR 18 0 Q86VQ1;H7C2L5;H7C0Q2 Q86VQ1 GLCCI1 Glucocorticoid-induced transcript 1 protein 1 T(0.11)S(0.11)S(0.768)LDT(0.011)IT(0.001)GPYLTGQWPR 82.59 0.0094689 3829200.0 7328.7 7249.7 10273.0 8823.4 8466.3 6098.7 7845.8 6888.2 5472.0 8520.2 True False 6921.4001931105695 7805.728678540389 9612.046364396687 7621.637698786021 7402.687704317687 6938.740566513516 8210.64524615776 6908.2435215971045 6566.552900454549 8274.199687861843 0.8365038860814763 0.9433817133989774 1.161688952044202 0.9211329175396719 0.8946711444706061 0.8385996021696901 0.9923189620626007 0.8349138022051147 0.7936178903305424 1.0 13.014404060365623 -5.987719643356252 24.997630821090592 0.8883636405678574 0.9875772560096764 0.14168428134783229 0.09628632505766087 408.83289582073905 832203.9880598072 0.027580012324996305 0.040877835766467 1.0286801431849501e-06 5.987719643356252 0.09921361544181895 TSS(ph)LDTLAAPYLAGHWPR ddPTM_A459_Selumetinib_30min_R1 1 TSSLDTLAAPYLAGHWPR 18 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.231)S(0.231)S(0.536)LDT(0.001)LAAPYLAGHWPR 266.83 5.3845e-54 43885000.0 1101.3 1212.8 1232.4 1030.1 1065.8 932.31 1186.6 1143.6 692.38 788.43 True False 1126.958147243235 1070.8048121845761 1065.0468490886321 850.2123723718278 969.3985781822728 922.9318078697511 1097.0938066628587 1113.268013063675 1174.9182905655973 889.6326704585489 1.2667679421691653 1.2036482558949242 1.1971759631305676 0.9556892418683293 1.0896616214449608 1.0374302096999637 1.2331986482661172 1.2513794176307131 1.3206779939410296 1.0 9.797065959674125 -10.235444316156638 13.038847066797075 0.999999999775157 1.1657373894139085 0.1870363658185048 0.10718928995216616 0.0 0.0 0.11372423790092695 0.027582179121081952 5.8150798661482244e-11 10.235444316156638 0.1657373896387515 TSS(ph)LDTLAAPYLAGHWPR ddPTM_A459_Selumetinib_30min_R2 1 TSSLDTLAAPYLAGHWPR 18 0 Q6P1L5;Q6P1L5-2 Q6P1L5 FAM117B Protein FAM117B 1 T(0.005)S(0.118)S(0.877)LDTLAAPYLAGHWPR 142.57 0.00030036 3092500.0 10101.0 8000.8 11420.0 12710.0 10347.0 7683.7 9228.0 11209.0 5758.3 11415.0 True False 9539.626857506768 8614.435633373238 10685.24963315587 10978.876074027048 9047.117356646364 8742.059929316069 9657.120284935105 11241.616334250151 6910.120900344927 11085.419290268173 0.8605562503063418 0.7770960581469212 0.9639012610498541 0.9903888871091544 0.816127664615156 0.7886088654301667 0.8711551662653875 1.014090314483558 0.6233522358880266 1.0 13.436375718681196 TSS(ph)LTQFPPSQSEER ddPTM_A459_Selumetinib_30min_R1 7 TSSLTQFPPSQSEER 15 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3 Q9H6Z4 RANBP3 Ran-binding protein 3 1 T(0.327)S(0.05)S(0.623)LTQFPPSQSEER;T(0.003)S(0.096)S(0.883)LT(0.018)QFPPSQSEER;TS(0.008)S(0.992)LTQFPPSQSEER;T(0.008)S(0.008)S(0.982)LT(0.003)QFPPSQSEER;T(0.017)S(0.003)S(0.952)LT(0.028)QFPPSQSEER;TS(0.007)S(0.91)LT(0.083)QFPPSQSEER;TS(0.008)S(0.966)LT(0.026)QFPPSQSEER 265.64 3.221199999999999e-37 85871200.0 21669.5 24898.8 25105.0 26083.5 24266.9 21743.899999999998 24996.399999999998 23588.6 13011.990000000002 19121.06 True False 22174.35718849295 21983.636920861907 21695.878891893946 21528.50637293524 22071.963179669165 21525.176107881576 23110.901423282892 22962.953701428643 22080.39667185167 21575.43430589671 1.0277594821084344 1.0189197866971156 1.0055824872069583 0.9978249368102572 1.0230136212663283 0.9976705823251308 1.0711673793267062 1.0643101490268827 1.023404505271857 1.0 14.397101980189232 -7.248303830006 24.999426881674218 1.045079688880887 1.0117115236017662 0.2845334477817748 0.02101702832458888 824.9087518524093 1569958.7489229091 0.007881369374321611 0.006065224954320614 5.645418862612849e-08 7.248303830006 -0.0333681652791209 TSS(ph)LTQFPPSQSEER ddPTM_A459_Selumetinib_30min_R2 8 TSSLTQFPPSQSEER 15 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3 Q9H6Z4 RANBP3 Ran-binding protein 3 1 T(0.343)S(0.053)S(0.584)LT(0.019)QFPPSQSEER;T(0.107)S(0.202)S(0.692)LTQFPPSQSEER;TS(0.004)S(0.996)LTQFPPSQSEER;TS(0.005)S(0.995)LTQFPPSQSEER;T(0.038)S(0.002)S(0.958)LT(0.002)QFPPSQSEER;TS(0.036)S(0.927)LT(0.036)QFPPSQSEER;T(0.031)S(0.005)S(0.964)LTQFPPSQSEER;TSS(0.999)LT(0.001)QFPPSQSEER 261.61 1.739e-36 89905600.0 360620.0 369745.0 364989.0 408851.0 400710.0 330891.0 319460.0 323427.0 299613.0 396593.0 True False 340578.1840762392 398103.252582441 341506.00510997605 353164.7884926854 350369.22740714834 376468.23172056774 334315.5229979807 324368.1190237775 359543.9718866751 385142.329617637 0.8842917484929783 1.0336522941471311 0.8867007826665473 0.9169721459682234 0.9097136317241192 0.9774782016152814 0.8680311076943521 0.8422032430083831 0.9335353302858829 1.0 18.555032167744137 -7.273781285553856 24.60962213104872 0.8977926956981529 0.9351575142072878 0.019946691643970116 0.05753742483166157 1646.5732956724871 3283234.874127298 0.02314602048115321 0.015729057031505317 5.323763010631126e-08 7.273781285553856 0.03736481850913487 TSS(ph)NASTISGR ddPTM_A459_Selumetinib_30min_R2 2 TSSNASTISGR 11 0 Q12778 Q12778 FOXO1 Forkhead box protein O1 1 T(0.002)S(0.01)S(0.968)NAS(0.02)TISGR;T(0.013)S(0.06)S(0.918)NAS(0.009)TISGR 96.23 0.020334 1204800.0 18333.9 16326.3 18596.5 19169.5 21444.3 17603.800000000003 21881.0 21376.6 17381.9 16478.9 True False 17314.97523441674 17578.474712671414 17400.02143633827 16558.58103076803 18750.275319525623 20028.563658614235 22898.509856378965 21438.80236691337 20858.76569086457 16003.1113396759 1.0819755525594816 1.0984410680871648 1.0872899067570108 1.0347101060101342 1.171664367105838 1.2515418554239628 1.4308786191849812 1.3396646384482103 1.3034193943992773 1.0 13.966064802033504 -6.645167093546456 2.649150468540789 1.2999200760562606 1.0792416384274675 0.39694189970551896 0.10625594930367917 0.23584646215580696 3.3600160706974465 0.036787790304133 0.0365118341892772 2.2637731598388731e-07 6.645167093546456 -0.22067843762879313 TSS(ph)PIPAQHAPRPYASSLEK ddPTM_A459_Selumetinib_30min_R2 1 TSSPIPAQHAPRPYASSLEK 20 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 T(0.13)S(0.13)S(0.741)PIPAQHAPRPYASSLEK 87.088 0.00093189 7401500.0 50603.0 38910.0 41762.0 58843.0 53469.0 35688.0 38691.0 39755.0 27912.0 46264.0 True False 47790.687839858925 41894.27188463061 39075.07838702762 50828.48189016321 46751.746201075155 40603.698056591486 40490.20816476205 39870.68046820544 33495.17992644141 44928.23811169227 1.063711595390199 0.9324708389516817 0.8697220284909992 1.1313259550441939 1.0405871266273476 0.9037456121838138 0.9012195863123497 0.8874303142955737 0.7455262288089707 1.0 15.455334866352622 -6.884095355526292 5.109085862468803 0.8779254508440467 1.0022205095133443 0.31651845251171296 0.08805809772874032 0.27511872331393233 11.194350247186554 0.032450024889772014 0.028595556244614347 1.305884131230184e-07 6.884095355526292 0.12429505866929758 TSS(ph)PLFNK ddPTM_A459_Selumetinib_30min_R1 2 TSSPLFNK 8 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 T(0.04)S(0.006)S(0.953)PLFNK;T(0.328)S(0.045)S(0.627)PLFNK 137.05 0.0025561 74954000.0 14140.8 16267.1 17471.5 18489.6 16006.0 13892.7 15342.0 14854.7 8058.5 12446.2 True False 14470.253126793003 14362.540369630387 15098.96626407987 15260.738452777547 14558.260126088811 13752.952051562348 14184.74058808494 14460.705101134121 13674.685930446965 14043.791006254442 1.0303665954832733 1.0226968176352091 1.0751346454355168 1.0866537707646842 1.0366332081989293 0.9792905665882832 1.0100364340203956 1.0296867202519608 0.9737175613306197 1.0 13.777644811464365 -6.576809831261777 6.388041673177429 1.0014605924593478 1.0540866499470884 0.5699040779282483 0.022785158543424992 0.16442016353745245 14.370922999943327 0.008048272437435585 0.008077304634752489 2.6496601170045385e-07 6.576809831261777 0.05262605748774063 TSS(ph)PLFNK ddPTM_A459_Selumetinib_30min_R2 1 TSSPLFNK 8 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 TSS(1)PLFNK 204.79 0.001036 15338000.0 176930.0 158740.0 165810.0 161100.0 160610.0 117150.0 119740.0 121090.0 88894.0 116220.0 True False 167096.93890690766 170914.84757045156 155141.9651202781 139157.90208699895 140432.7359283823 133286.34911818223 125308.14726030883 121442.35185247139 106675.28390588594 112864.42662417603 1.4805102360845626 1.5143376233113373 1.3745869248676628 1.232965126827577 1.24426039389723 1.1809420656697134 1.110253700021609 1.0760020272539792 0.9451630340629901 1.0 16.784231313780907 -5.863579829796363 0.3918322535692672 0.9654249762594072 1.681585256308593 0.9449535981118633 0.043084929902717464 0.5500226103808705 0.12251766724637513 0.04250881740390587 0.17189139790135052 1.3690527129747972e-06 5.863579829796363 0.7161602800491857 TSS(ph)PSSTGSVSLGR ddPTM_A459_Selumetinib_30min_R2 1 TSSPSSTGSVSLGR 14 0 D6RAL0;F5GYR0;Q6H8Q1-4;Q6H8Q1-6;Q6H8Q1-8;Q6H8Q1-3;Q6H8Q1-7;Q6H8Q1-2;Q6H8Q1-5;Q6H8Q1;Q6H8Q1-9 D6RAL0 ABLIM2 Actin-binding LIM protein 2 1 T(0.01)S(0.153)S(0.633)PS(0.114)S(0.038)T(0.038)GS(0.013)VS(0.001)LGR 75.483 0.044195 1778500.0 12494.0 12428.0 10900.0 12745.0 11651.0 10001.0 12106.0 13797.0 11052.0 13648.0 True False 11799.633497444773 13381.187637681558 10198.70586702267 11009.109013648691 10187.29721873845 11378.546969961095 12668.952987583918 13837.14698578369 13262.708818681238 13253.946778237421 0.8902731914405612 1.0096002241123423 0.7694844439671839 0.8306287325466942 0.7686236703066955 0.8585025396845809 0.95586267242192 1.0440020031243724 1.0006610891525687 1.0 13.694134410887424 -7.40978681349075 3.127796137278608 1.0154951155947547 0.8524957691445788 0.5586126030300709 0.06485557009277644 0.2129144384904817 3.950724959957063 0.03343253752494822 0.02070876103468165 3.892361663859512e-08 7.40978681349075 -0.16299934645017589 TSS(ph)TCS(ph)NESLSVGGTSVTPR ddPTM_A459_Selumetinib_30min_R2 2 TSSTCSNESLSVGGTSVTPR 20 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 2 T(0.206)S(0.097)S(0.553)T(0.387)CS(0.75)NES(0.006)LSVGGTSVTPR;T(0.341)S(0.114)S(0.544)T(0.003)CS(0.788)NES(0.19)LS(0.019)VGGTSVTPR 130.47 0.014699 0.0 27647.0 27696.0 28716.0 29645.0 30427.0 21116.0 25616.0 26418.0 22719.9 27392.0 True False 26110.49041970991 29820.194143323813 26868.443823616817 25607.299859522594 26604.488239168735 24024.53732803702 26807.194757141046 26494.87200626467 27264.51484704631 26601.121787036867 0.9815559895836404 1.121012654355639 1.0100492768207323 0.9626398489706334 1.0001265530137722 0.9031400074167001 1.0077467774387094 0.9960058157839053 1.0249385370030795 1.0 14.69919946597028 -5.5136103692760035 24.00174595329065 0.9832115642446291 1.0548459902662006 0.25970807439385546 0.04433833505720871 287.8607048605993 745452.1772210018 0.011446329881053941 0.02132437581364716 3.06471173100905e-06 5.5136103692760035 0.07163442602157155 TSS(ph)TDEVLSLEEK ddPTM_A459_Selumetinib_30min_R1 4 TSSTDEVLSLEEK 13 0 K7ENH8;A0A0A0MRB7;P15923-2;K7EMM4 K7ENH8 TCF3 Transcription factor E2-alpha 1 TSS(1)TDEVLSLEEK;TS(0.001)S(0.994)T(0.005)DEVLSLEEK;TS(0.018)S(0.978)T(0.004)DEVLSLEEK;TSS(0.945)T(0.055)DEVLSLEEK 311.54 4.318399999999998e-94 23429600.0 12237.0 13980.8 14206.8 14148.0 12439.8 13659.4 14957.100000000002 14480.2 9087.5 11704.5 True False 12522.09829094295 12343.921436502407 12277.594592366415 11677.317390851975 11314.622286425076 13521.998837742894 13828.873904969716 14096.138057681555 15420.82377526051 13206.886586484648 0.9481491499864562 0.9346579419508787 0.9296358011380798 0.884183968294392 0.8567213939736537 1.0238596923805432 1.0470956810609384 1.0673324076324642 1.1676350572315437 1.0 13.689002782876173 -6.934779009589421 4.386372199095651 1.071940461197007 0.911952178698897 0.7322483867938023 0.046077015951234875 0.1140982911850184 4.376290063176074 0.017459916853881836 0.015120820592778961 1.162039766458503e-07 6.934779009589421 -0.15998828249810992 TSS(ph)TLDSEGTFNSYR ddPTM_A459_Selumetinib_30min_R1 3 TSSTLDSEGTFNSYR 15 0 Q92609;Q92609-2;C9JNM0;C9JED7;F2Z3C3;C9K0P2;C9J397;C9JWX0;C9JW04;C9JDR8 Q92609 TBC1D5 TBC1 domain family member 5 1 T(0.004)S(0.007)S(0.964)T(0.025)LDSEGTFNSYR;TSS(0.993)T(0.007)LDSEGTFNSYR;T(0.07)S(0.014)S(0.81)T(0.102)LDSEGT(0.003)FNSYR 249.36 5.5661e-28 31953100.0 4911.9 6203.0 4929.8 5507.3 5415.0 5371.6 5717.4 5275.5 3564.64 5911.3 True False 5026.337713106373 5476.749876303533 4260.360237453051 4545.553439824645 4925.2142060959 5317.56658102257 5286.131914894852 5135.576602760943 6048.933728995281 6670.072935938031 0.7535656298486194 0.8210929518918855 0.6387276838456197 0.6814848178546028 0.7384048500518013 0.7972276513457264 0.7925148593823358 0.7699430953881635 0.9068766994141725 1.0 12.70348682174523 -8.431363205607624 0.7521794922875746 1.003761478284874 0.7298416548411296 0.7377891323380268 0.0506494849745225 0.3712071912705966 0.4777036617908 0.052754463206759826 0.020443311393629267 3.7037084670846998e-09 8.431363205607624 -0.27391982344374444 TSS(ph)TLDSEGTFNSYR ddPTM_A459_Selumetinib_30min_R2 2 TSSTLDSEGTFNSYR 15 0 Q92609;Q92609-2;C9JNM0;C9JED7;F2Z3C3;C9K0P2;C9J397;C9JWX0;C9JW04;C9JDR8 Q92609 TBC1D5 TBC1 domain family member 5 1 TS(0.028)S(0.97)T(0.002)LDSEGTFNSYR;T(0.005)S(0.001)S(0.906)T(0.077)LDS(0.012)EGTFNSYR 249.36 5.5661e-28 15302800.0 30654.0 29069.0 30040.0 32956.0 35199.0 35775.0 29631.0 32795.0 26160.0 31769.0 True False 28950.373397684645 31298.498828433 28107.259105079003 28467.335947729003 30776.986936947465 40702.6815168841 31008.900212712615 32890.42802049549 31392.730971471316 30851.74642422514 0.9383706516838374 1.0144806196078762 0.9110427240841337 0.9227139221323344 0.9975768150609791 1.319299107324566 1.0050938376818783 1.0660799414152307 1.0175349732169907 1.0 14.913064537846518 -6.534459976436517 24.999948818465416 1.0895596184203218 0.9503523256064618 0.33608575539190855 0.08957655697715027 252.9397201924894 546007.2998691082 0.02949569038660876 0.02951782528316166 2.921056945577922e-07 6.534459976436517 -0.13920729281386002 TSS(ph)TNEDEDLNPEQK ddPTM_A459_Selumetinib_30min_R1 1 TSSTNEDEDLNPEQK 15 0 Q99081;Q99081-3;B4DGI9;Q99081-4;Q99081-2;B4DZP2;F5GY10 Q99081 TCF12 Transcription factor 12 1 T(0.107)S(0.022)S(0.821)T(0.049)NEDEDLNPEQK 158.14 0.00014873 19024000.0 5325.7 5984.3 5137.7 5695.2 4738.3 5498.6 6400.0 5801.8 3658.6 6239.2 True False 5449.778447991731 5283.655373974404 4440.028559366006 4700.640232144487 4309.72160161481 5443.289076329347 5917.242847330442 5647.917417097614 6208.376986428399 7040.062094954503 0.7741094289349376 0.7505126095068271 0.6306803121165795 0.6676986891228358 0.6121709643304876 0.7731876513178007 0.8405100363491442 0.8022539206217206 0.881863952716815 1.0 12.78137243848032 -8.036867619374455 0.7258110915238494 0.9882761465656168 0.688851202553791 0.745821032771077 0.0567062077895328 0.35199005375012404 0.3846581181825847 0.05944050143591175 0.025958077003527993 9.186125631393561e-09 8.036867619374455 -0.29942494401182584 TSS(ph)TNEDEDLNPEQK ddPTM_A459_Selumetinib_30min_R2 3 TSSTNEDEDLNPEQK 15 0 Q99081;Q99081-3;B4DGI9;Q99081-4;Q99081-2;B4DZP2;F5GY10 Q99081 TCF12 Transcription factor 12 1 T(0.08)S(0.08)S(0.42)T(0.42)NEDEDLNPEQK;TSS(0.929)T(0.071)NEDEDLNPEQK;T(0.111)S(0.111)S(0.434)T(0.343)NEDEDLNPEQK 306.37 1.435899999999999e-81 159107000.0 453638.0 402260.0 406590.0 424791.0 404589.0 328823.0 422754.0 397793.0 358723.0 444816.0 True False 428426.6160167958 433112.04853023763 380430.4420617197 366933.7329946512 353760.91274844797 374115.383492002 442412.8986711584 398950.5117718234 430477.6235580699 431973.0063092358 0.9917902502224843 1.00263683657165 0.8806810529947364 0.8494367185804543 0.8189421736579571 0.8660619483805999 1.0241679276469629 0.9235542636806044 0.9965382495449371 1.0 18.720581636639082 -7.25644552122232 24.832590210447083 0.9796946322098112 0.8991065328601386 0.32311261546891534 0.059547701439093104 563.2847842891134 2801016.815233134 0.02637453092480762 0.019773443120322587 5.540570416147935e-08 7.25644552122232 -0.08058809934967259 TSS(ph)VLGMSVESAPAVEEEKGEELEQK ddPTM_A459_Selumetinib_30min_R1 1 TSSVLGMSVESAPAVEEEKGEELEQK 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.168)S(0.054)S(0.761)VLGMS(0.01)VES(0.007)APAVEEEKGEELEQK 83.318 6.0895e-05 6929200.0 1062.2 1244.8 1092.0 1364.9 921.34 1003.7 982.31 1015.3 690.94 1029.8 True False 1086.9471933185903 1099.0582373081797 943.712397926636 1126.5458373461875 838.0049596757882 993.6036892866846 908.2135658376818 988.3709458408089 1172.4747157390368 1161.9848611014465 0.9354228524873138 0.9458455734667501 0.8121555017783021 0.9695013033804362 0.7211840599037087 0.8550917680156751 0.781605334321469 0.8505884877914254 1.0090275312430894 1.0 10.182375557400963 -8.261809775116198 24.568505946446077 1.0045137894438505 0.8566522699671906 0.39018729030988875 0.0727590195281015 26.446877110596887 1753772.3485164575 0.058370090135784584 0.018608877344508695 5.4725561327956354e-09 8.261809775116198 -0.14786151947665993 TSS(ph)VLGMSVESAPAVEEEKGEELEQK ddPTM_A459_Selumetinib_30min_R2 2 TSSVLGMSVESAPAVEEEKGEELEQK 26 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.304)S(0.094)S(0.599)VLGMS(0.003)VESAPAVEEEKGEELEQK;T(0.138)S(0.118)S(0.744)VLGMSVESAPAVEEEKGEELEQK 134.97 2.7413000000000004e-09 1791100.0 13325.5 10170.5 11651.2 12119.5 10525.5 9715.7 9158.8 11421.6 5974.6 10438.4 True False 12584.922056202993 10950.544646688146 10901.574476867392 10468.803192696367 9203.192590836119 11053.949484656623 9584.702347817905 11454.834965052332 7169.686944271887 10137.016269779706 1.2414818839465553 1.0802532377632377 1.0754224109679071 1.032730234823217 0.9078798283349425 1.0904539551357397 0.9455151390445777 1.1300006491260435 0.7072778373303031 1.0 13.307345451393655 -1.5228787781103246 0.4424828758276487 0.9596059350108737 6.742220412552647 0.38166941337466187 0.10818513184535876 91.72920361055411 1.1233803783771759 0.06505458849068903 476.89953622035574 0.029999997732184924 1.5228787781103246 5.782614477541773 TSS(ph)VPEYVYNLHLVENDFVGGR ddPTM_A459_Selumetinib_30min_R1 3 TSSVPEYVYNLHLVENDFVGGR 22 0 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 T(0.038)S(0.038)S(0.924)VPEYVYNLHLVENDFVGGR;T(0.046)S(0.046)S(0.906)VPEY(0.002)VYNLHLVENDFVGGR;T(0.048)S(0.048)S(0.9)VPEY(0.004)VYNLHLVENDFVGGR 176.77 3.1476e-16 23954800.0 2888.31 2597.51 3438.1 2955.24 3191.36 2693.4300000000003 2610.4500000000003 2532.4500000000003 1683.8999999999999 2413.69 True False 2955.602003327075 2293.392321650362 2971.2249041314712 2439.162810725289 2902.7020514803703 2666.3365396387712 2413.5416548146486 2465.281199443079 2857.4553128100324 2723.5106228315694 1.0852177254422477 0.8420721044465678 1.0909540352893352 0.8955951154651085 1.0657942829914502 0.9790072112392366 0.8861877147023376 0.9051850867686297 1.0491808950020558 1.0 11.411251778966031 -7.016565067475847 24.511813422278127 0.9494315076347845 0.9906161246443642 0.02938956309888241 0.08615559680525631 1992.9320161421915 2948996.0428246576 0.030501559064257524 0.024274607712197287 9.625757857923742e-08 7.016565067475847 0.04118461700957976 TSS(ph)VPEYVYNLHLVENDFVGGR ddPTM_A459_Selumetinib_30min_R2 1 TSSVPEYVYNLHLVENDFVGGR 22 0 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 T(0.169)S(0.169)S(0.635)VPEY(0.025)VY(0.002)NLHLVENDFVGGR 69.05199999999999 0.0032246 1290800.0 1210.5 821.54 1987.0 1128.2 1151.0 1192.0 831.72 863.7 1116.2 1083.7 True False 1143.2252560154393 884.5494763325477 1859.1585832820233 974.5372137464461 1006.4010899294444 1356.187180101352 870.3966280219137 866.2132240067675 1339.4711892338028 1052.4107652092528 1.0862918679743168 0.8404983164122909 1.7665712331556809 0.9260046038703121 0.956281637549897 1.2886481447495444 0.827050289483547 0.8230752218070828 1.2727646214902346 1.0 10.039482195818026 TSS(ph)VVTLEVAK ddPTM_A459_Selumetinib_30min_R2 2 TSSVVTLEVAK 11 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 TS(0.001)S(0.998)VVT(0.001)LEVAK;T(0.009)S(0.174)S(0.817)VVTLEVAK 186.58 1.9173e-05 10428700.0 67985.0 62991.0 65707.0 67817.0 73058.0 52869.0 54717.0 61485.0 41969.0 67861.0 True False 64206.66586551807 67822.20715201156 61479.483156372415 58580.207609149664 63879.80089319322 60151.22485300196 57261.448919678594 61663.911170610285 50363.97271183794 65901.67660594727 0.9742797023122135 1.0291423624553273 0.9328971025120205 0.8889031452025776 0.9693198137455036 0.9127419505981679 0.8688921415773367 0.9356956354740973 0.7642290045666738 1.0 16.008027548884698 -5.414331345971922 0.6996650752044213 0.8925383262101994 1.0288463349678056 0.2358399613481943 0.06268461169047597 2.068534999433813 1.3377833164236297 0.029451066258929032 0.1969238376823399 3.851843682321152e-06 5.414331345971922 0.1363080087576063 TSSAELSTSAPDEPLLQKS(ph)PSESFIGR ddPTM_A459_Selumetinib_30min_R1 1 TSSAELSTSAPDEPLLQKSPSESFIGR 27 1 Q15139 Q15139 PRKD1 Serine/threonine-protein kinase D1 1 TSSAELSTSAPDEPLLQKS(0.563)PS(0.14)ES(0.297)FIGR 53.728 0.0064221 4743700.0 738.53 640.19 978.92 1230.5 858.87 760.32 607.81 576.7 363.61 593.03 True False 755.7363120707763 565.2362571837434 845.9880408226579 1015.6162743457285 781.185360145814 752.6718711153253 561.9624023493614 561.4040426143945 617.0196129763382 669.1511771013703 1.12939547583922 0.8447063631154836 1.2642704216516658 1.5177680456980978 1.1674273122103043 1.124815881480998 0.8398138142469846 0.8389793843691422 0.9220929949628787 1.0 9.386188376449132 -7.153398214654426 4.095587593995161 0.887173624716718 1.1853115149400233 0.4161743099708195 0.1598918490139037 0.25485398328409353 7.389978659879153 0.0707987592027896 0.05378359696854688 7.024279520767313e-08 7.153398214654426 0.2981378902233053 TSSAFVGKT(ph)PEAS(ph)PEPK ddPTM_A459_Selumetinib_30min_R2 1 TSSAFVGKTPEASPEPK 17 1 A0A087WW66;Q99460-2;Q99460 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 2 T(0.003)S(0.001)S(0.006)AFVGKT(0.99)PEAS(1)PEPK 110.44 0.040044 0.0 21303.0 17418.0 16906.0 17441.0 14018.0 14718.0 18374.0 13677.0 10007.0 13205.0 True False 20119.064542665743 18753.904592302646 15818.28636586105 15065.505712596834 12256.933517489966 16745.27090329841 19228.427407390296 13716.797805650756 12008.67961894165 12823.737339289646 1.5688924383240848 1.4624367371315399 1.2335160918647825 1.1748139652267213 0.9558004186452654 1.3058027048007201 1.4994402098737487 1.0696412007461298 0.9364414835719689 1.0 13.646529160623588 -5.2241957634428635 2.0275141622071096 1.1525473782855862 1.5726629897903937 0.46873591407786597 0.1612428699659436 0.37968844019537795 2.775572897407155 0.04869200586971333 0.20718059234429473 5.967662264183707e-06 5.2241957634428635 0.4201156115048075 TSSAFVGKTPEAS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 1 TSSAFVGKTPEASPEPK 17 1 A0A087WW66;Q99460-2;Q99460 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 TSSAFVGKT(0.196)PEAS(0.804)PEPK 104.2 0.023064 0.0 820.73 1127.5 1235.1 1028.2 937.76 993.38 684.96 915.15 491.57 843.91 True False 839.8514121374199 995.491775839471 1067.3802039186703 848.6441717044105 852.9397735749751 983.3874991168744 633.2929157355405 890.8772491738566 834.1583871477094 952.2340688795131 0.8819800084717269 1.045427598500922 1.120922091324299 0.8912138301279263 0.895724907825051 1.0327161474846405 0.6650601322012473 0.9355654017106796 0.8760014101672056 1.0 9.895172436106755 -5.79981863215165 24.558075724626633 0.892412877781387 1.0190416638541042 0.19696974137618273 0.10721702071904803 191.9218336935916 122805.8098963601 0.029917809773841182 0.044376402170735456 1.5855552057031444e-06 5.79981863215165 0.12662878607271721 TSSAFVGKTPEAS(ph)PEPK ddPTM_A459_Selumetinib_30min_R2 1 TSSAFVGKTPEASPEPK 17 1 A0A087WW66;Q99460-2;Q99460 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 T(0.001)S(0.001)S(0.002)AFVGKT(0.326)PEAS(0.67)PEPK 62.468 0.028823 8609800.0 72847.0 72752.0 74423.0 73838.0 67845.0 54589.0 63110.0 59652.0 49185.0 73624.0 True False 68798.45536964614 78331.84446544985 69634.70520563575 63781.13702234534 59321.70455800451 62108.13924039652 66044.74005009256 59825.57744407978 59023.37434372389 71498.28382187507 0.9622392551553396 1.0955765688110688 0.9739353377924135 0.8920652862276304 0.8296941043479269 0.8686661542132622 0.9237248297404029 0.8367414467335229 0.8255215536469359 1.0 16.12562099274978 -5.664882925206379 3.17689520037567 0.8734435900914761 1.0302657369917376 0.5174049967809733 0.057854149144440516 0.16818971388441065 3.36027481440912 0.015575952734576976 0.02902076763890126 2.1633016164592003e-06 5.664882925206379 0.15682214690026153 TSSAVST(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 TSSAVSTPSK 10 0 Q9P2N5;U3KPZ7 Q9P2N5 RBM27 RNA-binding protein 27 1 TSSAVS(0.021)T(0.973)PS(0.006)K;TSS(0.002)AVS(0.225)T(0.759)PS(0.013)K 145.46 0.0021056 26168900.0 16029.6 19923.9 15124.1 16507.3 14786.5 15698.3 16049.0 14794.5 8743.6 14236.400000000001 True False 16403.058491827993 17591.200525630185 13070.330290734644 13624.609935397993 13449.063685768602 15540.389354915967 14838.411008875966 14402.101800691282 14837.250592722732 16063.780614279129 1.0211206742482077 1.095084709386116 0.813652190886895 0.8481571220716901 0.837229043940858 0.9674179278259118 0.9237184798008304 0.8965574260824518 0.9236462417529451 1.0 13.971523850959436 -5.251275998976809 24.998987819161364 0.8965791170714728 1.0581027059758508 0.54524913824192 0.05715114745990622 507.64183115469547 1248646.5893437446 0.014823311199905088 0.038264553114488814 5.606915370718754e-06 5.251275998976809 0.161523588904378 TSSAVST(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 TSSAVSTPSK 10 0 Q9P2N5;U3KPZ7 Q9P2N5 RBM27 RNA-binding protein 27 1 TSSAVS(0.044)T(0.808)PS(0.148)K;TSSAVS(0.054)T(0.94)PS(0.005)K 114.71 0.016076 19918700.0 99538.0 93777.0 81577.0 98387.0 95856.0 76967.0 93757.0 87689.0 75243.0 105323.0 True False 94006.07644218492 100969.3943594193 76328.42463432184 84986.52087295814 83813.71231648722 87568.5056131382 98116.88627597105 87944.1604723045 90293.70246507703 102282.05132798191 0.9190867334166098 0.987166301892466 0.7462543392834772 0.8309035629373211 0.8194371468726869 0.8561473345146096 0.9592776543104843 0.8598200694108008 0.8827912746444384 1.0 16.642193474534857 -7.222089570806426 23.34711873442455 0.9137905927097875 0.8573066773970804 0.16741532773921763 0.06965658633233449 546.3720326709166 324174.30026732676 0.027978110025570137 0.021671086959053155 5.996673854583823e-08 7.222089570806426 -0.05648391531270702 TSSAVWNS(ph)PPLQGAR ddPTM_A459_Selumetinib_30min_R1 2 TSSAVWNSPPLQGAR 15 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 TSSAVWNS(1)PPLQGAR;T(0.083)S(0.012)S(0.009)AVWNS(0.896)PPLQGAR 93.738 0.012164 12498200.0 3314.5 3860.8 3882.9 4501.9 3511.5 3343.7 3100.07 3502.4 2057.99 2459.5 True False 3391.721401105694 3408.7757411627745 3355.623507242981 3715.7276761292446 3193.885445005677 3310.0654138366926 2866.2292240193246 3409.5049746014492 3492.2587203574553 2775.200782558758 1.2221535185567722 1.2282987820505928 1.2091462096479622 1.3389040892037054 1.150866440034976 1.1927300664656 1.0328006687057207 1.2285615498630185 1.2583805619777766 1.0 11.438376437214197 -6.358053002934105 24.999938884519246 1.1522048232596258 1.2452146898352898 0.28198445882373935 0.0818950593410973 72.5419054435352 18763.38649369898 0.025155326590557008 0.028523460157849165 4.384771811028965e-07 6.358053002934105 0.09300986657566401 TSSAVWNS(ph)PPLQGAR ddPTM_A459_Selumetinib_30min_R2 3 TSSAVWNSPPLQGAR 15 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 TSSAVWNS(1)PPLQGAR;T(0.245)S(0.011)S(0.007)AVWNS(0.737)PPLQGAR;T(0.008)SSAVWNS(0.992)PPLQGAR 171.87 4.2902e-05 20108600.0 94777.0 65038.0 75761.0 88969.0 91873.0 72082.0 86435.0 83953.0 78008.0 78564.0 True False 89509.67376239169 70026.20546986903 70886.61974233988 76851.26871991454 80331.09238495913 82010.64120475309 90454.39876770333 84197.28933083269 93611.77972563195 76295.6531862137 1.1731949334508835 0.9178269343727496 0.9291043038759748 1.0072824009035581 1.0528921246521894 1.0749058141568157 1.1855773558545017 1.103566006903874 1.226960853158371 1.0 16.21931324387881 -6.735006398709092 1.83205507993517 1.1366738906362455 0.9964059493643684 0.27455212125942074 0.08595615380223076 0.3935698325432797 2.7276283258722636 0.03429580207690634 0.03198666750318626 1.84074488052162e-07 6.735006398709092 -0.14026794127187703 TSSEEEDSRREEPS(ph)LLLVLK ddPTM_A459_Selumetinib_30min_R1 1 TSSEEEDSRREEPSLLLVLK 20 2 A0A087WZV0;O43314;O43314-2;D6RBU4 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 T(0.183)S(0.183)S(0.183)EEEDS(0.202)RREEPS(0.25)LLLVLK 46.621 0.038606 6206000.0 1327.0 1386.1 1907.2 2054.3 1197.8 1729.0 1278.7 1232.6 776.35 1129.8 True False 1357.916518107484 1223.8147676195915 1648.2127154997063 1695.55506898694 1089.4592014887662 1711.6078298063937 1182.2466295127238 1199.9074439509316 1317.409247639449 1274.8208351839328 1.0651822441477137 0.9599896188102526 1.292897535097079 1.3300340112046436 0.8545978944026105 1.3426261813170326 0.9273825755618025 0.9412361414518358 1.0334073708870404 1.0 10.31607878793889 TSSESIYSRPGSSIPGS(ph)PGHTIYAK ddPTM_A459_Selumetinib_30min_R1 1 TSSESIYSRPGSSIPGSPGHTIYAK 25 1 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 TSSES(0.001)IY(0.001)S(0.003)RPGS(0.002)S(0.218)IPGS(0.377)PGHT(0.377)IY(0.021)AK 105.68 1.7537e-07 13290000.0 435.93 575.77 827.46 708.93 1115.3 698.89 825.21 609.85 177.51 329.74 True False 446.08632082787904 508.35858073178895 715.0954769124304 585.1286837642556 1014.421311922208 691.859801141348 762.9637453196173 593.6747969280186 301.2215051825578 372.0653409395911 1.1989461842948335 1.3663153344195167 1.9219620809252802 1.5726503368645068 2.726460114130626 1.8595115562072175 2.0506176237562874 1.5956197248278716 0.8095930258429107 1.0 8.539412194902628 -5.110131847379348 4.448779286205129 1.7637778460949762 1.2327036986613369 0.08349084517552441 0.5104456178270849 0.45773663234608614 14.416632346105125 0.13333179147080418 0.40146375030000636 7.760114916823335e-06 5.110131847379348 -0.5310741474336393 TSSESIYSRPGSSIPGS(ph)PGHTIYAK ddPTM_A459_Selumetinib_30min_R2 1 TSSESIYSRPGSSIPGSPGHTIYAK 25 1 F8W8M4;A0A0A0MRL6;A0A3B3IS55;O14639-2;O14639-6;O14639;O14639-3;O14639-5;A0A494C1P1;A0A494C1G0;H0Y7N6;F6XFR5 F8W8M4 ABLIM1 Actin-binding LIM protein 1 1 TSSESIYSRPGSSIPGS(0.927)PGHT(0.072)IY(0.001)AK 84.03 6.3036e-05 4311800.0 5961.2 3133.2 7376.8 6282.6 6339.4 3964.4 4615.2 3450.3 3774.6 5749.3 True False 5629.900368574333 3373.5063651741107 6902.184719252559 5426.899041910494 5542.987897044937 4510.4601147599005 4829.815944845303 3460.3398017720847 4529.625471135918 5583.302770524645 1.0083458841414952 0.6042134026804914 1.236218955506148 0.9719872385499426 0.9927793861202481 0.8078480247518561 0.865046396971852 0.6197657451141464 0.8112806446837708 1.0 12.446903077156934 -6.771892744973444 22.712119083245685 0.799789505772175 0.9585030031603534 0.1449804806291184 0.16835573362366538 126.63965167289666 275146.7747576807 0.05865943116249173 0.05239903220576743 1.6908584609573765e-07 6.771892744973444 0.15871349738817842 TSSFT(ph)EQLDEGTPNR ddPTM_A459_Selumetinib_30min_R1 1 TSSFTEQLDEGTPNR 15 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71;C9J0Y3;C9JHJ5 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 TSS(0.07)FT(0.93)EQLDEGTPNR 287.88 1.0629e-66 55566000.0 3186.4 3498.3 3022.8 2491.4 3058.9 2899.7 3374.5 2796.3 1713.2 2367.1 True False 3260.636920344905 3088.7174096844537 2612.3203630518624 2056.323759370132 2782.2230350926584 2870.531650716945 3119.958748174462 2722.1330403374914 2907.1752728227025 2670.940342506541 1.2207823845608485 1.1564157239041326 0.9780526811019422 0.7698875660548739 1.041664237427963 1.0747269809939288 1.168112480283457 1.0191665448367553 1.0884463522290682 1.0 11.38313203729885 -6.68237046507512 5.453574956567012 1.0773017329635501 1.0214883282877623 0.018309265325931245 0.11875626899301826 0.8622358992448683 43.74442049735578 0.044068580223709894 0.0436651633106745 2.077923405366692e-07 6.68237046507512 -0.05581340467578788 TSSFT(ph)EQLDEGTPNR ddPTM_A459_Selumetinib_30min_R2 2 TSSFTEQLDEGTPNR 15 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71;C9J0Y3;C9JHJ5 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 TSS(0.068)FT(0.932)EQLDEGTPNR;T(0.054)S(0.006)S(0.129)FT(0.811)EQLDEGTPNR 301.75 2.5677999999999996e-80 200962000.0 208413.0 184993.0 200000.0 206904.0 237406.0 161569.0 180820.0 197033.0 160400.0 213171.0 True False 196830.23980334212 199181.36825375116 187132.21774353518 178723.3182706922 207580.9358434317 183823.66317264686 189228.4882880328 197606.3334094311 192484.48195045846 207016.19934522588 0.9507963165486515 0.9621535362147716 0.9039496345475282 0.8633301105709524 1.0027279821578796 0.8879675298554656 0.9140757529437114 0.9545452676381976 0.9298039600730282 1.0 17.65938413974886 -9.341685095921395 0.8810709693445685 1.0007742141080704 0.9275064968586951 0.23417872665792472 0.038065937042150846 6.0517278826823935 5.306163349822563 0.050345763536456874 0.01227911075607806 4.553180886427179e-10 9.341685095921395 -0.07326771724937531 TSSGDPPS(ph)PLVK ddPTM_A459_Selumetinib_30min_R1 2 TSSGDPPSPLVK 12 0 F5GX58;F8WDL1;Q99618 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 TSSGDPPS(1)PLVK;TSSGDPPS(1)PLVK 105.19 0.0094261 69697000.0 11354.9 11685.900000000001 13362.8 12704.3 10930.4 11305.6 10845.400000000001 11595.3 6878.5 9762.7 True False 11619.44707721076 10317.709395372474 11548.20515660627 10485.732494246597 9941.747249918859 11191.875928663489 10027.322746318367 11287.75497715743 11672.312114237078 11015.83764175092 1.0547946924319318 0.9366250421363798 1.0483274656152912 0.9518779084492692 0.9024958040629455 1.015980472174478 0.9102642098058887 1.0246842177825788 1.0595936953535032 1.0 13.427291580957139 -7.9701382653217125 24.984549080531636 1.0339109506771265 0.9732625471451783 0.18461252939630668 0.05166521242410142 285.9313462255813 239231.3026661131 0.02708484917816265 0.01301097931496938 1.0711782224322307e-08 7.9701382653217125 -0.060648403531948114 TSSGDPPS(ph)PLVK ddPTM_A459_Selumetinib_30min_R2 4 TSSGDPPSPLVK 12 0 F5GX58;F8WDL1;Q99618 F5GX58 CDCA3 Cell division cycle-associated protein 3 1 TSSGDPPS(1)PLVK;TSS(0.001)GDPPS(0.999)PLVK;TSSGDPPS(1)PLVK;TSSGDPPS(1)PLVK 187.74 0.00011883 33160000.0 757740.0 688930.0 717150.0 789120.0 671180.0 564167.0 809580.0 704720.0 557230.0 807520.0 True False 715627.8442735554 741768.7157409047 671009.3497738816 681640.4946920731 586860.3679746691 641875.8832518782 847227.074152336 706770.6185273229 668691.5703070713 784204.7994110709 0.9125522373887331 0.9458864779939689 0.8556557550754627 0.8692123475959055 0.7483509007027178 0.8185054257942822 1.0803645613857429 0.9012577059692822 0.852700175782208 1.0 19.580870945754924 TSSIS(ph)GPLSPAYTGQVPYNYNQLEGR ddPTM_A459_Selumetinib_30min_R1 1 TSSISGPLSPAYTGQVPYNYNQLEGR 26 0 Q01082-3 Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 T(0.049)S(0.049)S(0.05)IS(0.852)GPLSPAYTGQVPYNYNQLEGR 118.98 5.1227e-09 16141000.0 546.96 705.24 975.67 992.07 842.37 773.43 831.92 811.28 495.51 493.3 True False 559.7031038011079 622.6701729428188 843.179372971686 818.8235979603136 766.1777822325028 765.6499964182525 769.1676046173654 789.762218991167 840.8442793814952 556.6198601489062 1.0055392268097958 1.1186632341437528 1.5148208559179324 1.4710642874676856 1.3764830130702412 1.3755348151131848 1.3818544031317868 1.418853827421628 1.5106257242717742 1.0 9.120548574597999 -5.112407342220027 4.6696279988174005 1.3981478010585489 1.0298309719006469 0.4606969545279217 0.13909290826441306 0.16136306883859486 5.3914278019393835 0.03306917760318879 0.09756370191051032 7.71956196741786e-06 5.112407342220027 -0.368316829157902 TSSIS(ph)GPLSPAYTGQVPYNYNQLEGR ddPTM_A459_Selumetinib_30min_R2 2 TSSISGPLSPAYTGQVPYNYNQLEGR 26 0 Q01082-3 Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 T(0.134)S(0.134)S(0.312)IS(0.421)GPLSPAYTGQVPYNYNQLEGR;T(0.083)S(0.083)S(0.358)IS(0.477)GPLSPAYTGQVPYNYNQLEGR 188.94 9.6431e-28 37893000.0 64560.0 52305.0 54216.0 69065.0 56208.0 43018.0 45718.0 46379.0 34886.0 40574.0 True False 60972.01365415674 56316.625312917145 50727.80158591755 59658.227856229656 49146.64853410447 48943.33902147645 47843.97758849837 46513.95521154325 41864.174796282416 39402.52319608771 1.547413939729897 1.4292644415855287 1.2874252070982684 1.5140712578059756 1.2472969888127432 1.242137179335156 1.2142363916747547 1.180481640225559 1.0624744661133558 1.0 15.266000397198809 -6.5370312182649055 0.2751783371193107 0.9620919168507509 1.6396726024769746 0.8320743702770868 0.06984659371962429 1.312147552300932 0.18855737145897822 0.10854445568006228 0.29852253087030856 2.903813912944622e-07 6.5370312182649055 0.6775806856262236 TSSISGPLS(ph)PAYTGQVPYNYNQLEGR ddPTM_A459_Selumetinib_30min_R1 3 TSSISGPLSPAYTGQVPYNYNQLEGR 26 0 Q01082-3 Q01082-3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 1 T(0.01)S(0.003)S(0.003)IS(0.041)GPLS(0.799)PAY(0.13)T(0.013)GQVPYNYNQLEGR;T(0.001)S(0.001)S(0.001)IS(0.007)GPLS(0.988)PAY(0.003)TGQVPYNYNQLEGR;TSSIS(0.001)GPLS(0.999)PAYTGQVPYNYNQLEGR 129.05 4.2405e-09 25268400.0 5036.9 5440.6 6588.700000000001 6975.3 6125.9 6271.2 8866.4 10839.1 7402.1 4588.7 True False 5154.249969898713 4803.612022733683 5693.990729138483 5757.194797597524 5571.813426615486 6208.117421794021 8197.600309620402 10551.6118576412 12560.823072006135 5177.704342723065 0.9954701212599527 0.927749385591098 1.0997133772500987 1.111920344715877 1.0761165678465818 1.1990096403474904 1.5832499824254371 2.0378938539568834 2.425944441895292 1.0 12.338096871478859 -7.355085449018038 2.2907502353447478 1.9165845169185072 1.049212251655645 0.5037617818368498 0.3399395592271063 0.22483481221957996 2.3039495052921595 0.16532428356718815 0.10054368574425054 4.414835753090988e-08 7.355085449018038 -0.8673722652628622 TSSLAPVVGTTTTTPS(ph)PSAIK ddPTM_A459_Selumetinib_30min_R2 1 TSSLAPVVGTTTTTPSPSAIK 21 0 Q92733 Q92733 PRCC Proline-rich protein PRCC 1 TSSLAPVVGTTTTT(0.009)PS(0.976)PS(0.014)AIK 201.61 8.486e-17 3472500.0 30256.0 30286.0 28677.0 35035.0 32367.0 22555.0 26644.0 27849.0 25903.0 30974.0 True False 28574.49264436441 32608.838815161227 26831.9530411568 30263.172561253963 28300.76809534868 25661.746516095616 27882.99879408442 27930.03597934987 31084.323790291364 30079.70013988319 0.9499593583540084 1.084081246272951 0.8920286078776383 1.0060995428982853 0.9408593823654581 0.8531250776024282 0.9269706368220697 0.9285343886230087 1.0333987255769257 1.0 14.876502564621523 -2.8925756590348133 18.460157488407237 0.9576908272677825 0.499003966159159 0.0 0.06574353044354864 0.0 0.0 0.01512982683835684 0.0 0.0012806319744565722 2.8925756590348133 -0.45868686110862356 TSSLT(ph)QFPPSQSEER ddPTM_A459_Selumetinib_30min_R1 2 TSSLTQFPPSQSEER 15 0 Q9H6Z4;Q9H6Z4-3;Q9H6Z4-2;B7Z7F3 Q9H6Z4 RANBP3 Ran-binding protein 3 1 TS(0.004)S(0.361)LT(0.635)QFPPSQSEER;T(0.001)S(0.01)S(0.177)LT(0.812)QFPPS(0.001)QSEER 209.53 3.2276e-06 8625000.0 4884.8 6072.0 5829.9 6546.4 5851.6 5544.299999999999 5650.700000000001 5639.0 3273.7 4360.9 True False 4998.606335833791 5361.087417203784 5038.231601348439 5403.194131147397 5322.323813183887 5488.529375821625 5224.463149595331 5489.435401946542 5555.22979841214 4920.663993763155 1.0158398017359904 1.0895048765774002 1.0238926306966496 1.0980619969166434 1.0816271584342738 1.1154042183693558 1.061739463661253 1.1155883451713617 1.1289593854514928 1.0 12.264637290444934 -5.775565841294061 24.897802973690037 1.0907708761438362 1.0477216779132956 0.192158305812845 0.039025798293331936 326.22823096671726 574975.8356585446 0.010303808854132297 0.015372194840325948 1.676618132482343e-06 5.775565841294061 -0.04304919823054054 TSSPRS(ph)PPSSSEIFTPAHEENVR ddPTM_A459_Selumetinib_30min_R1 1 TSSPRSPPSSSEIFTPAHEENVR 23 1 I3L2L5;I3L3A7;I3L317;I3L4Q0;C9JLW8 I3L2L5 FAM195B Protein FAM195B 1 T(0.071)S(0.071)S(0.071)PRS(0.779)PPS(0.003)S(0.003)S(0.001)EIFTPAHEENVR 92.289 5.528e-05 40922000.0 1519.4 1797.3 2334.9 2211.1 1993.4 1752.3 1720.4 1391.1 787.37 1406.6 True False 1554.7990637622543 1586.8712804578981 2017.8334046876405 1824.9728924874762 1813.097321963354 1734.673452961102 1590.6288428980142 1354.2035090703728 1336.1093827704942 1587.150811444256 0.9796164627527975 0.99982387874905 1.2713558095033686 1.1498421443812323 1.1423598242144954 1.0929480931825282 1.00219136797126 0.8532292579292394 0.8418288754517775 1.0 10.632223504571414 -7.4798000343950815 2.6796557941191823 0.8864354175801051 1.112936745345554 0.5337995321081415 0.08660131577077836 0.2196409560330676 3.1291050001504597 0.04773393082359788 0.027255562086952026 3.31283621880412e-08 7.4798000343950815 0.22650132776544896 TSSS(ph)SPANSDVEIDGIGR ddPTM_A459_Selumetinib_30min_R1 1 TSSSSPANSDVEIDGIGR 18 0 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 TSS(0.003)S(0.902)S(0.093)PANS(0.002)DVEIDGIGR 240.34 4.8576e-25 16134000.0 2163.4 4363.8 4155.9 4581.9 3693.8 3873.5 3834.9 2728.9 1462.2 2443.3 True False 2213.8030107563927 3852.884267324419 3591.5516067246385 3781.75717791523 3359.6964421933562 3834.536106856603 3545.6304055042956 2656.5207072835474 2481.246605137376 2756.9213547573963 0.8029982454654399 1.3975314387099973 1.3027399568460625 1.3717319761005722 1.2186406537842653 1.3908761308115134 1.286083260730629 0.9635823316829131 0.9000063062574089 1.0 11.428842397596044 -7.771638598225809 9.105527142447126 0.9480854114632595 1.2690724047645285 0.40821288408317724 0.16379925218623115 0.14803947646667842 96.85421468811856 0.08314914297720513 0.04226139658664308 1.6918482316261434e-08 7.771638598225809 0.320986993301269 TSSS(ph)SPANSDVEIDGIGR ddPTM_A459_Selumetinib_30min_R2 1 TSSSSPANSDVEIDGIGR 18 0 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 TSSS(0.5)S(0.5)PANSDVEIDGIGR 289.81 1.0095999999999996e-80 20732000.0 24558.0 22566.0 24821.0 24152.0 24823.0 19414.0 19927.0 16720.0 17656.0 18380.0 True False 23193.16467346316 24296.739638873663 23224.043883061448 20862.455935476115 21704.512819564377 22088.10227725474 20853.6449846014 16768.652431854993 21187.69334985847 17849.32164302489 1.299386337324843 1.3612136149929417 1.3011163307787037 1.1688094568920881 1.2159853048558855 1.2374757270333727 1.168315827439332 0.9394560066324874 1.18703073279752 1.0 14.12358162574553 -6.709876779068966 0.3620963122112837 0.9980288433907695 1.3890108775536159 0.6448184751309184 0.0745108902867605 1.1087842520945812 0.29407611759330043 0.0845629515627914 0.16516582788497589 1.950397901180266e-07 6.709876779068966 0.3909820341628464 TSSSS(ph)PANSDVEIDGIGR ddPTM_A459_Selumetinib_30min_R1 2 TSSSSPANSDVEIDGIGR 18 0 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 T(0.002)S(0.001)S(0.002)S(0.024)S(0.971)PANSDVEIDGIGR;T(0.177)S(0.005)S(0.005)S(0.033)S(0.694)PANS(0.086)DVEIDGIGR 275.69 8.177299999999996e-55 23089300.0 3146.9 4400.1 3931.2 4457.9 4021.7 3439.2 3777.6000000000004 3737.2 2048.44 2902.5 True False 3220.2166471985242 3884.9342464490055 3397.3646325358905 3679.411450146949 3657.9379450888036 3404.6047705437522 3492.6525906367942 3638.0773158635593 3476.053067861857 3275.064147744175 0.983252999614243 1.1862162300316779 1.0373429280388156 1.1234624068909562 1.1169057398794304 1.039553613900602 1.066437917877881 1.1108415443921682 1.0613694605817479 1.0 11.677307449243798 -8.545838020292717 17.691829616851273 0.9999999967030666 1.0854428575485187 0.1792337873302252 0.05334711404544069 132.85992608130348 102380.74678606183 0.04743501551383904 0.012247668339123751 2.845522209833395e-09 8.545838020292717 0.08544286084545205 TSSSS(ph)PANSDVEIDGIGR ddPTM_A459_Selumetinib_30min_R2 1 TSSSSPANSDVEIDGIGR 18 0 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 TSSS(0.006)S(0.993)PANSDVEIDGIGR 357.28 6.772299999999995e-185 15382000.0 26275.0 23459.0 29414.0 27764.0 32286.0 19718.0 22538.0 25600.0 20348.0 24616.0 True False 24814.740687158734 25258.2298674261 27521.535263541737 23982.495304428565 28229.94403949786 22433.975517817493 23586.06165819976 25674.491761691865 24418.16857062303 23905.27211995107 1.038044685818432 1.0565966260783899 1.151274711513222 1.0032303829920868 1.1809087090850334 0.9384530494047106 0.9866468593141469 1.0740096005961892 1.0214553696815651 1.0 14.545041207902678 -6.775083565487658 24.999999414764574 1.007646968753513 1.083403747830611 0.3342959045470473 0.0576190092202726 304.6397436161345 558182.0632595904 0.019946793336334877 0.017681114702650807 1.6784810193599822e-07 6.775083565487658 0.0757567790770981 TSSSS(ph)PLSSPSK ddPTM_A459_Selumetinib_30min_R2 1 TSSSSPLSSPSK 12 0 A0A087WVA8;Q8IWB9;Q8IWB9-2 A0A087WVA8 TEX2 Testis-expressed sequence 2 protein 1 TSS(0.001)S(0.129)S(0.87)PLSSPSK 132.5 0.0027143 0.0 30675.0 20470.0 29892.0 34569.0 25213.0 22305.0 35178.0 26736.0 18134.0 22097.0 True False 28970.206301754322 22039.983178575912 27968.781263948786 29860.642565148813 22045.517532920134 25377.311285369666 36813.846703884585 26813.797333616927 21761.306706294377 21459.002195099067 1.3500257858387614 1.0270739980449572 1.303358889181551 1.391520551312892 1.027331901664795 1.1825951204369365 1.715543265673944 1.2495360730118579 1.0140875381085683 1.0 14.389295374485936 -8.249121846405593 5.588611043717031 1.0031144793743967 1.2804300425412818 0.25882448043824435 0.1858217339508135 0.22919244369863312 26.908076703188478 0.15206429349183123 0.04929300446689398 5.634795428586432e-09 8.249121846405593 0.2773155631668851 TSSSSPANS(ph)DVEIDGIGR ddPTM_A459_Selumetinib_30min_R1 1 TSSSSPANSDVEIDGIGR 18 0 O60293-2;O60293 O60293-2 ZFC3H1 Zinc finger C3H1 domain-containing protein 1 T(0.034)S(0.034)S(0.01)S(0.013)S(0.063)PANS(0.847)DVEIDGIGR 91.202 0.0054581000000000005 4275900.0 1267.7 1442.8 1701.3 1792.6 1769.3 1495.7 1709.9 1538.4 802.31 1297.4 True False 1297.2349434851988 1273.876305260478 1470.2728045719646 1479.5560612695267 1609.2671273952865 1480.6546159869415 1580.920866351612 1497.59663457254 1361.461471596066 1463.9339277461816 0.8861294344631889 0.8701733603658539 1.0043300293173354 1.0106713378433658 1.0992757916833409 1.0114217506158236 1.0799127176357879 1.02299468998453 0.9300019938004455 1.0 10.51563472608186 -5.321745078533755 3.756480626448706 1.0269870788126354 0.8759719967782512 0.6279551537988242 0.043572608221451564 0.13528934103349358 3.81842309225051 0.011836826380567551 0.028559949733928554 4.767107235802304e-06 5.321745078533755 -0.15101508203438418 TSSSSSGESCAGDKS(ph)PPGQASSK ddPTM_A459_Selumetinib_30min_R1 1 TSSSSSGESCAGDKSPPGQASSK 23 1 O43365 O43365 HOXA3 Homeobox protein Hox-A3 1 TSSSSS(0.002)GES(0.002)CAGDKS(0.991)PPGQAS(0.002)S(0.002)K 85.182 0.0051795 0.0 514.56 524.01 706.32 628.4 472.53 554.78 408.7 475.02 354.72 536.8 True False 526.5482468405326 462.6586655943602 610.4056235380415 518.6617365289358 429.7897449319471 549.1994168999369 377.87142995374245 462.42092651758213 601.9339322762487 605.7035088747881 0.8693168177590685 0.7638368588186628 1.0077630632716468 0.8562964039822893 0.7095711658173568 0.9067132827415536 0.6238554415108343 0.7634443580764767 0.9937765316804221 1.0 9.24246795880369 -8.272015188091515 23.793238087523402 0.9968883742766972 0.812347613691359 0.34508778292353326 0.10155075253304961 484.148638963712 1089205.3101650802 0.09608689284024519 0.025966202383304868 5.345456650069142e-09 8.272015188091515 -0.1845407605853382 TSSSSSGESCAGDKS(ph)PPGQASSK ddPTM_A459_Selumetinib_30min_R2 4 TSSSSSGESCAGDKSPPGQASSK 23 1 O43365 O43365 HOXA3 Homeobox protein Hox-A3 1 T(0.012)S(0.012)S(0.012)S(0.042)S(0.038)S(0.035)GES(0.038)CAGDKS(0.809)PPGQAS(0.001)SK;T(0.002)S(0.002)S(0.002)S(0.003)S(0.007)S(0.018)GES(0.006)CAGDKS(0.94)PPGQAS(0.012)S(0.007)K;T(0.002)S(0.002)S(0.003)S(0.008)S(0.037)S(0.127)GES(0.146)CAGDKS(0.59)PPGQAS(0.065)S(0.021)K;T(0.001)S(0.001)S(0.002)S(0.007)S(0.006)S(0.057)GES(0.162)CAGDKS(0.76)PPGQAS(0.002)S(0.001)K 57.845 0.0083853 22341400.0 107165.2 88087.5 94844.8 92530.7 79275.5 68012.2 87807.7 84307.5 57681.3 81609.0 True False 101209.38720028546 94843.52800404541 88742.58882721045 79927.85903563933 69316.20295803797 77380.26319671911 91890.93203765678 84552.82086714197 69219.17175018063 79252.73612435357 1.2770459690057923 1.1967224431876864 1.1197416413228507 1.0085186069819272 0.8746222067245172 0.9763733970686336 1.1594669980033612 1.066875732018541 0.8733978804412568 1.0 16.274173123317524 -5.409426003032296 1.8792705148644715 0.9980077435531081 1.2581226964744983 0.60186899285816 0.08019057716270765 0.28647254859647464 1.8922322255025548 0.025445868452241147 0.08197023429552949 3.89559676907967e-06 5.409426003032296 0.2601149529213902 TSST(ph)CSNESLSVGGTSVTPR ddPTM_A459_Selumetinib_30min_R2 1 TSSTCSNESLSVGGTSVTPR 20 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 TSS(0.04)T(0.951)CS(0.008)NESLSVGGTSVTPR 191.89 1.9155000000000003e-18 0.0 5582.8 5238.0 6088.1 7088.3 7622.8 4440.5 5298.1 5611.2 4334.5 4705.3 True False 5272.53032571912 5639.737757175414 5696.398274222091 6122.861312000471 6665.15571530336 5052.138568154406 5544.472147985983 5627.527663015832 5201.52111604902 4569.445763162404 1.1538664860024792 1.2342279675669654 1.246627833980406 1.3399571040674714 1.4586354802667723 1.1056348690870428 1.2133795727884484 1.2315558504673345 1.1383264810761584 1.0 12.15780347330926 -8.62891043615838 0.7492834264050713 0.9992174887769142 1.2664654829191238 0.43124914844972395 0.09060669548916456 0.8405514372801949 1.033074612221514 0.094825134105475 0.03539759626963471 2.3501174317555673e-09 8.62891043615838 0.26724799414220957 TSST(ph)LDSEGTFNSYR ddPTM_A459_Selumetinib_30min_R2 1 TSSTLDSEGTFNSYR 15 0 Q92609;Q92609-2;C9JNM0;C9JED7;F2Z3C3;C9K0P2;C9J397;C9JWX0;C9JW04;C9JDR8 Q92609 TBC1D5 TBC1 domain family member 5 1 TS(0.006)S(0.379)T(0.615)LDSEGTFNSYR 89.624 0.038363 7314300.0 10208.0 12629.0 11466.0 12890.0 14077.0 14773.0 16036.0 14880.0 9839.2 15491.0 True False 9640.680225861708 13597.60369136469 10728.290043236877 11134.359763509736 12308.521410023273 16807.84665405811 16781.70577473118 14923.298336483398 11807.314930217912 15043.73457954835 0.6408435468522568 0.9038715499441444 0.7131400774526937 0.740132691429339 0.8181825692907702 1.11726556761431 1.1155279087112828 0.9919942589768446 0.7848659432126458 1.0 13.87687513742775 -6.613865807336279 5.887293508259733 1.007553547206227 0.7604146321176538 0.5659949898297019 0.10554783241008893 0.16350980219298097 8.556379989864576 0.036212477849679375 0.036183123356179625 2.432955651975525e-07 6.613865807336279 -0.2471389150885731 TSSTCS(ph)NESLSVGGTSVTPR ddPTM_A459_Selumetinib_30min_R2 1 TSSTCSNESLSVGGTSVTPR 20 0 A0A3B3IRT3;O60343-2;O60343-3;O60343;Q5JU47 A0A3B3IRT3 TBC1D4 TBC1 domain family member 4 1 TSST(0.007)CS(0.983)NES(0.002)LS(0.008)VGGTSVTPR 167.63 2.9417e-09 3762600.0 9297.0 7409.6 11086.0 9911.3 13412.0 7587.8 8193.2 9298.5 7240.8 7931.5 True False 8780.309958839765 7977.892494380861 10372.738829524167 8561.363842053845 11727.064655198701 8632.950574809594 8574.200034517804 9325.557095550459 8689.162324855875 7702.496986488132 1.1399303335324056 1.0357540559088607 1.34667223469483 1.1115049907935508 1.5225016868906982 1.1207989551899444 1.1131714883574546 1.2107186944583723 1.1280968158895188 1.0 12.911110497489261 -8.786633768050395 0.8395284015327595 0.99986605833303 1.2097294269953338 0.17691297521867588 0.13324331195234212 1.8234755178950175 2.5146239940656536 0.1312718370545927 0.04532540901512136 1.634429649125325e-09 8.786633768050395 0.20986336866230382 TSSVSNPQDSVGS(ph)PCSR ddPTM_A459_Selumetinib_30min_R1 4 TSSVSNPQDSVGSPCSR 17 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 TSSVSNPQDSVGS(0.999)PCSR;TSSVSNPQDSVGS(1)PCSR;TSSVSNPQDS(0.001)VGS(0.999)PCSR;TSSVSNPQDSVGS(1)PCSR 295.16 2.5188999999999996e-76 166423700.0 6185.1900000000005 6414.42 7317.57 7800.5 6832.300000000001 6441.74 6704.88 6466.77 3932.28 4593.73 True False 6329.292892715322 5663.416724417043 6323.884186534814 6438.2891085199935 6214.319671340539 6376.941944231952 6199.125503470144 6295.250252570642 6672.791957632063 5183.379992219412 1.221074453776493 1.092610754549772 1.2200309828774607 1.2421024733251818 1.1988933245620876 1.2302671140846617 1.1959620002344864 1.2145068009716091 1.2873437733001158 1.0 12.339677445854381 -4.443416925034757 22.89389032291241 1.1958999908916277 2.8812763537238513 0.005127859261271461 0.0785243202478053 4734.902993018375 1511760.4060134862 0.01772239363097312 44827.95758241444 3.602326516914001e-05 4.443416925034757 1.6853763628322236 TSSVSNPQDSVGS(ph)PCSR ddPTM_A459_Selumetinib_30min_R2 5 TSSVSNPQDSVGSPCSR 17 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 TSSVSNPQDS(0.001)VGS(0.985)PCS(0.014)R;TSSVSNPQDS(0.001)VGS(0.952)PCS(0.047)R;TSSVSNPQDSVGS(0.999)PCS(0.001)R;TSSVSNPQDS(0.001)VGS(0.989)PCS(0.01)R;TSSVSNPQDS(0.002)VGS(0.871)PCS(0.127)R 196.01 9.141e-08 188852000.0 176048.7 159659.9 178951.0 189963.1 181424.8 138450.1 155200.9 138597.1 130866.6 184070.5 True False 166264.6180327842 171905.30094250652 167437.4874871172 164089.7980753747 158632.59466570953 157520.34455012612 162418.04937474887 139000.39461501504 157043.57671831577 178755.9063924058 0.9301209755150655 0.9616762008699126 0.9366822661487764 0.9179545525906373 0.8874257520614649 0.8812035793901921 0.9086024213275952 0.7775988912493931 0.8785364348944811 1.0 17.44763138615864 -6.110460105300851 1.4602206884517774 0.8755885450012131 0.9472755117473928 0.1590206753686777 0.05168977616947279 0.5844404657859855 2.505374479337925 0.01822361079159902 0.028865925421155948 7.754251713728037e-07 6.110460105300851 0.07168696674617969 TSSVSSISQVS(ph)PER ddPTM_A459_Selumetinib_30min_R2 4 TSSVSSISQVSPER 14 0 P42356 P42356 PI4KA Phosphatidylinositol 4-kinase alpha 1 TSSVSSISQVS(1)PER;TSSVSSISQVS(1)PER;TS(0.001)SVS(0.001)S(0.016)IS(0.016)QVS(0.965)PER;T(0.001)SSVSSIS(0.004)QVS(0.995)PER 221.78 5.875100000000001e-09 29324500.0 42577.600000000006 37582.1 47509.0 48461.8 56721.7 33666.7 42081.2 43452.4 27300.9 42085.2 True False 40211.30744363733 40464.526224502115 44452.32266388811 41861.219238732025 49595.81294756817 38303.98232912599 44038.05918231588 43578.83929006794 32761.84285088078 40870.090925518554 0.9838810370380191 0.990076736023036 1.0876492236070088 1.0242506999805725 1.2134989627977908 0.9372130441043298 1.077513119864857 1.0662770329893758 0.8016092479604657 1.0 15.31875783253975 -8.239623257806926 24.786056887420248 0.9008046078852011 1.04904272025216 0.3291967564691439 0.08376569102068966 679.9677696953097 772537.8397494188 0.0542178700663366 0.02045126881752788 5.759393371036585e-09 8.239623257806926 0.14823811236695883 TSSVVT(ph)LEVAK ddPTM_A459_Selumetinib_30min_R1 1 TSSVVTLEVAK 11 0 A8MQ02;J3KN01;P55196;P55196-5;P55196-3;P55196-1;Q5TIG5;P55196-2;P55196-6 A8MQ02 MLLT4 Afadin 1 T(0.063)SS(0.21)VVT(0.726)LEVAK 187.62 4.5243e-05 6162800.0 3643.1 4454.6 4326.3 5311.1 4646.4 3956.1 4340.4 3944.5 2212.3 3171.1 True False 3727.9771417614015 3933.0533611126425 3738.8122226648406 4383.616086694513 4226.1339403885495 3916.3052258514035 4013.000133523914 3839.8790464582603 3754.1115200009685 3578.141574129733 1.0418752485130809 1.0991888609296379 1.0449033793678737 1.225109738079798 1.1810974643775574 1.094508181053154 1.1215319602047737 1.0731489984132858 1.0491791457172945 1.0 11.804994755409691 -8.282640504565395 1.335219119376155 1.0027422419134857 1.118859626901584 0.33501375176512427 0.05282256922991022 0.5095943921139234 1.7994634656466495 0.0532745086428132 0.016692521304335014 5.216263184515369e-09 8.282640504565395 0.11611738498809832 TST(ph)FCGTPEFLAPEVLTDTSYTR ddPTM_A459_Selumetinib_30min_R1 1 TSTFCGTPEFLAPEVLTDTSYTR 23 0 Q16512;Q16512-2 Q16512 PKN1 Serine/threonine-protein kinase N1 1 T(0.168)S(0.168)T(0.664)FCGT(0.001)PEFLAPEVLTDTSYTR 159.75 1.6965e-09 3285700.0 668.12 645.91 624.74 562.16 401.73 620.98 504.17 740.18 484.04 445.02 True False 683.6858960647876 570.2865569245872 539.9037394511779 463.989309050138 365.3935924311922 614.7335050047278 466.1400509904041 720.5480219565152 821.3805271171499 502.14265186188163 1.3615371917318047 1.1357062675517338 1.0751999206784824 0.9240189163970122 0.7276689026043871 1.2242208518343811 0.9283020457673046 1.434946860787097 1.635751362828022 1.0 8.971953462114145 -7.76993655215746 24.99999993265772 1.401511964320365 1.046799117590549 0.2768521022512662 0.22077322881431477 218.31181001730963 642295.6788090048 0.11792674871774565 0.0580772105027372 1.6984917738898067e-08 7.76993655215746 -0.35471284672981596 TST(ph)PVIMEGVQEETDTR ddPTM_A459_Selumetinib_30min_R1 2 TSTPVIMEGVQEETDTR 17 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.002)S(0.101)T(0.896)PVIMEGVQEETDTR;T(0.076)S(0.418)T(0.506)PVIMEGVQEETDTR 197.29 1.8209e-07 16077800.0 1724.37 2708.6000000000004 2126.1000000000004 2245.4 1898.9499999999998 2007.8 2068.3 1593.76 785.27 1624.88 True False 1764.5444659600614 2391.4758528060233 1837.387297831337 1853.2830413782178 1727.1903077868524 1987.6033549365397 1912.2864658021174 1551.488307537919 1332.545836148425 1833.449175671508 0.9624179875691345 1.3043589560807627 1.0021479309119035 1.0108177886629695 0.9420442795499155 1.0840787851174396 1.0429994412589783 0.8462128801414307 0.726797259411554 1.0 10.84034455888022 -7.758800305801457 5.999835474691969 0.8380078397607379 1.0541212265325668 0.3744788482793596 0.11299766504641096 0.14849700492372556 19.916149705401875 0.058139137963562064 0.030261519805282855 1.7426079627961986e-08 7.758800305801457 0.2161133867718289 TST(ph)SPPPEK ddPTM_A459_Selumetinib_30min_R2 1 TSTSPPPEK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 TST(0.996)S(0.004)PPPEK 172.98 0.0010696 42091000.0 364780.0 275270.0 283690.0 357830.0 354090.0 280290.0 428620.0 473380.0 400290.0 307250.0 True False 344506.98793003854 296382.32386744505 265437.6942583171 309092.9367088192 309606.04859523644 318897.4032807113 448551.6792944179 474757.45742772234 480359.18503708846 298378.8941686281 1.1545956991694637 0.9933086074779315 0.8895994302744002 1.0359075080361952 1.0376271735234173 1.068766623622136 1.5032956018696149 1.5911227861827733 1.6098966596666004 1.0 18.186785964603878 -7.2239592630360425 5.0612578786630085 1.4766575867200036 1.0190897603158982 0.5530664647703323 0.17217526879353215 0.1290203023649135 8.549342498563162 0.06555597967209777 0.04896610458241443 5.970912913149075e-08 7.2239592630360425 -0.4575678264041054 TSTPS(ph)PQPSK ddPTM_A459_Selumetinib_30min_R2 2 TSTPSPQPSK 10 0 Q8IY18 Q8IY18 SMC5 Structural maintenance of chromosomes protein 5 1 T(0.391)S(0.002)T(0.1)PS(0.503)PQPS(0.005)K;T(0.008)S(0.002)T(0.079)PS(0.898)PQPS(0.013)K 100.38 0.017491 36514000.0 86963.0 76935.0 85895.0 92286.0 94624.0 78268.0 90913.0 88351.0 73764.0 78920.0 True False 82129.94460047137 82835.6671149848 80368.60921540472 79716.48759777016 82736.48717070694 89048.70655383613 95140.63464069198 88608.08678270449 88518.86113836447 76641.37454121465 1.0716136694065317 1.0808217834146372 1.0486321480597365 1.0401234069060419 1.0795277050545926 1.161888171850954 1.2413743256852623 1.1561390608287514 1.154974864011117 1.0 16.225835815180055 -6.7015355488921085 4.6038769175014185 1.1589978489189439 1.0611420062867563 0.30230120636606483 0.057679390479749494 0.21109033622971674 8.97321592822955 0.018955238121940676 0.018539144571173775 1.9882200592771945e-07 6.7015355488921085 -0.0978558426321876 TSTS(ph)PPPEK ddPTM_A459_Selumetinib_30min_R1 1 TSTSPPPEK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 T(0.001)S(0.005)T(0.47)S(0.524)PPPEK 115.7 0.0080838 326780000.0 9586.0 10722.0 7515.3 6797.4 9142.8 7642.8 10307.0 11060.0 5630.3 10300.0 True False 9809.335148890987 9466.663255477431 6494.763538587953 5610.361693000935 8315.835354292441 7565.92037110718 9529.534691786697 10766.65287205688 9554.207879158104 11622.105330496124 0.8440239414412747 0.8145394475678288 0.5588284870853691 0.4827319606439533 0.715518842569073 0.6509939598683886 0.8199490901860464 0.9263943636619298 0.8220720435296773 1.0 13.504583814448813 -7.438014347895194 3.0197568184737964 0.9049072667512166 0.6710530015702396 0.49532496557872896 0.10863715063564479 0.25495320598799165 4.500822972720253 0.05785934287849824 0.03495904281051891 3.647418966574791e-08 7.438014347895194 -0.23385426518097696 TSTS(ph)PPPEK ddPTM_A459_Selumetinib_30min_R2 2 TSTSPPPEK 9 0 Q9H1E3;Q9H1E3-2 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 TST(0.476)S(0.523)PPPEK;T(0.001)ST(0.044)S(0.955)PPPEK 109.83 0.011204 477053000.0 152694.0 103385.0 122358.0 145502.0 142461.0 113756.0 177160.0 184049.0 156249.0 120674.0 True False 144207.87876251244 111314.29706483027 114485.61949331775 125684.37659504963 124563.77556250105 129424.85642584693 185398.29103588016 184584.55211904796 187503.16596182776 117189.82807129415 1.2305494524215999 0.9498631314409864 0.976924545223061 1.0724853740598348 1.0629231018815117 1.1044035011904738 1.5820339878226495 1.5750902203453465 1.5999952303689486 1.0 16.83848782552831 -7.196516339986383 5.671744569186761 1.486674261786742 1.0536610744632517 0.5066706351555168 0.1779256614185201 0.15249395606447166 9.729469422721634 0.06559193817953021 0.050183445178325195 6.360388739275061e-08 7.196516339986383 -0.43301318732349015 TSTS(ph)SSSVQAR ddPTM_A459_Selumetinib_30min_R2 1 TSTSSSSVQAR 11 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 T(0.02)ST(0.026)S(0.483)S(0.087)S(0.087)S(0.296)VQAR 130.69 0.0023466 1572100.0 5325.1 6354.1 6137.4 5844.4 6028.2 4179.8 5147.1 4623.9 3881.4 6575.3 True False 5029.152260064282 6841.439038348275 5742.526365895867 5048.382637847659 5270.883623208232 4755.529509553378 5386.45034878516 4637.354783472148 4657.7884553772465 6385.454004318908 0.7875950960828676 1.071409962975374 0.8993137155183974 0.7906066873918599 0.8254516624257543 0.7447441491766907 0.8435500976347092 0.726237285608133 0.7294373199191277 1.0 12.640573483524161 -5.666305072883569 4.4177301242382345 0.7966275161139774 0.9413798826543286 0.20279952695791303 0.09873482637591119 0.25814215826168624 8.911777151045985 0.025588101891424592 0.045423575504439345 2.156229220294072e-06 5.666305072883569 0.14475236654035117 TSTSSSS(ph)VQAR ddPTM_A459_Selumetinib_30min_R2 1 TSTSSSSVQAR 11 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 TSTS(0.002)S(0.002)S(0.17)S(0.826)VQAR 89.35600000000002 0.031577999999999995 0.0 3769.3 3026.1 2497.7 3081.6 2450.7 2101.0 3251.4 4526.9 3363.5 5138.9 True False 3559.8173957034214 3258.192139554888 2337.0007012901406 2661.880763943491 2142.821156464021 2390.3936790209227 3402.5965425268723 4540.072529531359 4036.293984042196 4990.52660453431 0.713314982124137 0.6528754173145873 0.46828739459414576 0.5333867495115546 0.42937776436600683 0.47898626105891323 0.6818111217832863 0.9097381677930189 0.8087911965793121 1.0 12.284976342642477 -7.5990524501821595 3.2040023702506284 0.8966285443149138 0.5423668991459085 0.7548380001416082 0.09151730802717914 0.13319534731389518 2.7481377258486126 0.05215539909993265 0.02794614099637178 2.5173728837397872e-08 7.5990524501821595 -0.35426164516900527 TSTTGVATTQS(ph)PTPR ddPTM_A459_Selumetinib_30min_R1 3 TSTTGVATTQSPTPR 15 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 TSTTGVATTQS(0.961)PT(0.039)PR;TSTTGVATTQS(0.874)PT(0.126)PR;TSTTGVATT(0.001)QS(0.993)PT(0.006)PR 196.18 2.1129e-05 104294600.0 7594.999999999999 8772.5 9926.1 11096.4 8653.7 7996.099999999999 9163.0 8428.8 4884.1 7844.6 True False 7771.948722702597 7745.411621775394 8578.19014016445 9158.62204522546 7870.974362934823 7915.666493877912 8471.827532826377 8205.24084339901 8287.960979449781 8851.530822874749 0.8780344189298623 0.8750363950334056 0.9691193887046168 1.0346935720493797 0.889221821675647 0.8942709066121862 0.957103093504785 0.9269855133074212 0.9363308048401582 1.0 13.111711267494341 -14.52287814338359 0.008597550584133497 2.019185579738313 0.003053309435115105 0.18424086538885254 0.046464954612074054 38593.413834567305 25.117959657477073 3352.79514080014 2583.8683630634478 3.0000041577583175e-15 14.52287814338359 -2.016132270303198 TSTTGVATTQS(ph)PTPR ddPTM_A459_Selumetinib_30min_R2 2 TSTTGVATTQSPTPR 15 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 TSTTGVATT(0.001)QS(0.685)PT(0.313)PR;TSTTGVATTQS(0.906)PT(0.094)PR 224.36 6.2513e-10 89823000.0 180944.0 158431.0 193388.0 208779.0 212225.0 185441.0 228303.0 395650.0 184393.0 340850.0 True False 170887.85685622285 170582.14826404344 180945.6266249344 180342.94003613645 185563.3981844278 210983.814484207 238919.54187381212 396801.2759966165 221276.75237089113 331008.7748653441 0.5162638269204217 0.5153402604913935 0.5466490327893692 0.5448282756537218 0.5605996344354189 0.637396439324112 0.7217921699236091 1.1987636163362652 0.6684921040564786 1.0 18.336509937049115 -7.42459390350493 2.76425022044016 0.9515909970737919 0.5479530122069299 0.659729873794381 0.1275646030506901 0.15528097798893867 2.303536004775924 0.058605240824515306 0.03513616292302447 3.7618900358213736e-08 7.42459390350493 -0.403637984866862 TSTTGVATTQSPT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 TSTTGVATTQSPTPR 15 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;Q8WWI1-3 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 TSTTGVATT(0.03)QS(0.33)PT(0.639)PR 143.93 0.0008779 7656900.0 627.75 770.25 889.46 855.59 973.25 563.12 806.66 848.37 529.23 611.56 True False 642.3753536111326 680.0687719204897 768.6762174540527 706.1772679134187 885.2197093412431 557.4555240720513 745.8129867543078 825.8684717058674 898.0646565701369 690.059683098855 0.9308982532154522 0.985521670917653 1.1139271519271405 1.0233567982731355 1.2828161549244288 0.807836680979075 1.0807949008194206 1.1968073080246264 1.30143041039174 1.0 9.430577335414888 -7.650120277808417 4.919640511716613 1.1856700759720322 1.0313750890199391 0.17532060213407674 0.13445472314476578 0.3355131940871631 12.993702641279839 0.06502563866022402 0.036198443628066755 2.2381012108466467e-08 7.650120277808417 -0.1542949869520931 TSVATSTEGKDKDVT(ph)LSPVK ddPTM_A459_Selumetinib_30min_R1 1 TSVATSTEGKDKDVTLSPVK 20 2 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 TSVATSTEGKDKDVT(0.506)LS(0.494)PVK 71.143 0.032882 45841000.0 2009.3 2069.2 4230.6 4235.8 2523.1 2670.0 2040.5 2470.2 1641.9 1863.1 True False 2056.1127805827946 1826.937102055018 3656.107757022369 3496.0970458135994 2294.8860504894856 2643.1422241660334 1886.5834421840254 2404.682271659575 2786.184380368663 2102.2470331308064 0.9780547900313573 0.8690401619139029 1.7391427836040037 1.6630286501615268 1.09163481471147 1.2572938301307481 0.8974128218292213 1.1438628447382617 1.3253363360533759 1.0 11.037716493701566 TSVATSTEGKDKDVTLS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 TSVATSTEGKDKDVTLSPVK 20 2 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 TSVATSTEGKDKDVT(0.119)LS(0.88)PVK 65.105 0.019502 6391100.0 12631.0 18730.0 11976.0 17351.0 13470.0 9399.9 4342.3 4874.2 2069.8 13643.0 True False 11929.019585899227 20166.530773557748 11205.477198482893 14987.763867855505 11777.778176672131 10694.650901203608 4544.225554104214 4888.383115032751 2483.8178350440107 13249.09114122898 0.9003651238218213 1.5221067285742218 0.8457544052673395 1.1312295845875844 0.8889498948363056 0.8071988325239625 0.3429839455148237 0.36895988282705006 0.18747080902136604 1.0 13.693605776884628 -6.881988769167461 1.6207467601459065 0.420220805407338 1.109644314756247 0.5094955590926783 0.2677108495841736 0.2700333506534916 1.4596295609752323 0.11673286756599352 0.09643410968068548 1.3122338328785763e-07 6.881988769167461 0.689423509348909 TSVLGGGEDGIEPVS(ph)PPEGMTEPGHSR ddPTM_A459_Selumetinib_30min_R1 11 TSVLGGGEDGIEPVSPPEGMTEPGHSR 27 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 TSVLGGGEDGIEPVS(0.999)PPEGMT(0.001)EPGHSR;TSVLGGGEDGIEPVS(0.999)PPEGMT(0.001)EPGHSR;TSVLGGGEDGIEPVS(0.991)PPEGMT(0.008)EPGHS(0.001)R;TSVLGGGEDGIEPVS(1)PPEGMTEPGHSR;TSVLGGGEDGIEPVS(0.998)PPEGMT(0.001)EPGHSR;TSVLGGGEDGIEPVS(0.995)PPEGMT(0.005)EPGHSR;TSVLGGGEDGIEPVS(0.997)PPEGMT(0.003)EPGHSR;TSVLGGGEDGIEPVS(1)PPEGMTEPGHSR;TSVLGGGEDGIEPVS(0.986)PPEGMT(0.01)EPGHS(0.004)R;TSVLGGGEDGIEPVS(0.989)PPEGMT(0.011)EPGHSR;TSVLGGGEDGIEPVS(0.952)PPEGMT(0.047)EPGHS(0.001)R 170.33 7.976699999999998e-22 367409300.0 10875.119999999999 13955.11 11539.32 12112.35 13634.2 11715.769999999999 13302.47 12704.210000000001 6551.93 11304.070000000002 True False 11128.489136700131 12321.239233645374 9972.34372494761 9997.155449468899 12400.989017313514 11597.919990868042 12299.053978019956 12367.25308171011 11118.146675966163 12755.05749546614 0.8724765953156869 0.9659885294931073 0.7818344784797981 0.7837797244757576 0.9722409343683097 0.9092801028133813 0.9642491993777156 0.969596027780049 0.8716657435623613 1.0 13.638781781683635 -6.279565783011965 24.949608235541213 0.9452110699826497 0.8542900650864306 0.3943791006146671 0.05866710230695971 929.9446544781083 1279994.4771202186 0.018947786148312506 0.021523375776606707 5.253324364628962e-07 6.279565783011965 -0.09092100489621913 TSVLGGGEDGIEPVS(ph)PPEGMTEPGHSR ddPTM_A459_Selumetinib_30min_R2 8 TSVLGGGEDGIEPVSPPEGMTEPGHSR 27 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 TSVLGGGEDGIEPVS(0.999)PPEGMT(0.001)EPGHSR;TSVLGGGEDGIEPVS(0.983)PPEGMT(0.016)EPGHS(0.001)R;TSVLGGGEDGIEPVS(0.999)PPEGMTEPGHSR;TSVLGGGEDGIEPVS(0.996)PPEGMT(0.003)EPGHSR;TSVLGGGEDGIEPVS(0.993)PPEGMT(0.006)EPGHSR;TSVLGGGEDGIEPVS(0.995)PPEGMT(0.004)EPGHSR;TSVLGGGEDGIEPVS(1)PPEGMTEPGHSR;TSVLGGGEDGIEPVS(0.996)PPEGMT(0.004)EPGHS(0.001)R 142.79 7.8276e-13 186747000.0 85629.1 70155.2 96991.4 109667.1 107539.79999999999 74716.6 86542.9 85300.4 79329.1 99524.79999999999 True False 80870.1774224467 75535.87825547771 90751.07892025184 94730.25179370021 94029.68890599004 85008.13344023538 90567.31633150304 85548.61004175867 95197.13664025023 96651.2604275148 0.8367213946795511 0.7815301934125016 0.9389539103663536 0.9801243292087713 0.9728759717159524 0.8795346596021748 0.9370526150502246 0.8851266880882247 0.9849549423273676 1.0 16.560500926271196 -5.269903251174002 24.424547094473088 0.9425208504072317 0.809125793012168 0.6512363645712593 0.040332332145554456 243.8609996539179 703722.089319912 0.010497405554496991 0.022441967247107196 5.371514455616016e-06 5.269903251174002 -0.13339505739506363 TSVLGGGEDGIEPVSPPEGMT(ph)EPGHSR ddPTM_A459_Selumetinib_30min_R1 1 TSVLGGGEDGIEPVSPPEGMTEPGHSR 27 0 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 TSVLGGGEDGIEPVS(0.238)PPEGMT(0.753)EPGHS(0.009)R 81.96700000000001 0.00012037 4331500.0 441.86 612.23 535.06 541.12 901.51 486.1 584.29 767.68 233.21 583.79 True False 452.1544782901077 540.5498269819944 462.4017908741994 446.62355008042283 819.968579674518 481.21027534348656 540.2165348854222 747.3186326239261 395.74033701551616 658.7251330961483 0.6864084207093867 0.8205999738332364 0.7019647006647713 0.6780120078024002 1.244781075561048 0.7305175575762471 0.820094008477086 1.1344923627118484 0.6007670227420235 1.0 9.363532785748852 TSVPENHAQSR ddPTM_A459_Selumetinib_30min_R1 1 TSVPENHAQSR 11 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 105.25 0.017822 0.0 230.86 244.17 285.79 333.37 538.91 324.75 452.62 406.93 126.3 205.45 False True 236.23858882463742 215.58246288844663 246.9812877321001 275.15318762993525 490.1656856522881 321.4833098494079 418.4785089935476 396.1368945050731 214.321875412974 231.8215087524687 1.0190537974493348 0.9299502192380191 1.065394186506734 1.186918285152456 2.1144098677041687 1.3867708461542154 1.8051755044023334 1.708801295603916 0.9245124689522222 1.0 7.856870617771163 -6.01408797284418 23.42197297222927 1.5464130114683783 1.0187878228460903 0.29205525572512314 0.3371684801716347 315.12478817735916 523914.0375962155 0.09513892975730097 0.12824171283816554 9.68081736960536e-07 6.01408797284418 -0.527625188622288 TSVPENHAQSR ddPTM_A459_Selumetinib_30min_R2 2 TSVPENHAQSR 11 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 ; 114.72 0.008971 1645650.0 7837.6 6233.84 9924.0 11904.599999999999 14360.5 8375.699999999999 8851.0 9839.1 9585.5 13035.7 False True 7402.017568398684 6711.955483045123 9285.500644434229 10283.172943419542 12556.405605501119 9529.37664796551 9262.58903792377 9867.730152049311 11502.867841247646 12659.325470183865 0.5847086865593618 0.5301985085108676 0.7334909483371839 0.8123002262355286 0.9918700356567062 0.7527554821471151 0.7316810883596975 0.7794830913614224 0.9086477686619252 1.0 13.627912914904467 -5.468616557539654 2.620539904256926 0.8410260169846319 0.5550828472001172 0.6342112569856353 0.08901096267630591 0.18856702471543887 2.52706017570841 0.025599050652067832 0.06155165847678085 3.3992526317662895e-06 5.468616557539654 -0.2859431697845146 TSVPS(ph)PEQPQPYR ddPTM_A459_Selumetinib_30min_R2 2 TSVPSPEQPQPYR 13 0 Q8TEH3 Q8TEH3 DENND1A DENN domain-containing protein 1A 1 T(0.429)S(0.031)VPS(0.54)PEQPQPYR;T(0.139)S(0.058)VPS(0.803)PEQPQPYR 141.59 0.0012955 0.0 258690.0 212196.0 297300.0 290040.0 291870.0 166734.0 221984.0 229520.0 161996.0 182969.0 True False 244313.0454181199 228470.75088232002 278172.04167576495 250536.05165309235 255202.68124909358 189700.09503944503 232306.69585295138 230187.86520091863 194399.72654642427 177686.209559446 1.3749690874934415 1.285810257581547 1.5655240908422936 1.4099915366210454 1.4362548555785022 1.067612931300556 1.3073985675586814 1.2954740031409577 1.0940619816721717 1.0 17.43897219084993 -6.746909827631992 24.985862625311423 1.1810321889196038 1.4154986858407304 0.5746693925692656 0.11121885850798509 193.67396562002816 333052.4578851429 0.03681270876983908 0.03665518894440912 1.790977675322875e-07 6.746909827631992 0.23446649692112653 TSVS(ph)PAPDK ddPTM_A459_Selumetinib_30min_R1 2 TSVSPAPDK 9 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 T(0.055)S(0.004)VS(0.941)PAPDK;T(0.456)S(0.008)VS(0.536)PAPDK 105.2 0.013882 53191000.0 12569.6 15883.2 13862.7 14630.7 12528.0 12107.7 12657.7 11382.3 7097.2 10394.7 True False 12862.447223816003 14023.58756010065 11980.221482360414 12075.722897253183 11394.844611998049 11985.907530912016 11702.919498227266 11080.404429078937 12043.430041021056 11728.960997952236 1.0966399518304872 1.1956376666738882 1.0214222286570862 1.0295645879768454 0.9715135564000494 1.0219070157198613 0.9977797266331164 0.9447046870574017 1.026811329931417 1.0 13.517787598415262 -5.376624044562874 5.0305152169766645 0.9984127929079003 1.1451107106557383 0.7531165099797128 0.033203909007057754 0.09387040213063566 3.466178573641996 0.008469268826899131 0.01826109986990231 4.201225138182121e-06 5.376624044562874 0.14669791774783802 TSVS(ph)PAPDK ddPTM_A459_Selumetinib_30min_R2 3 TSVSPAPDK 9 0 O75362 O75362 ZNF217 Zinc finger protein 217 1 T(0.145)S(0.003)VS(0.852)PAPDK;T(0.483)S(0.007)VS(0.51)PAPDK;T(0.098)S(0.001)VS(0.901)PAPDK 103.21 0.01544 57960000.0 592560.0 577110.0 587440.0 637870.0 633130.0 500360.0 523670.0 607710.0 483910.0 596770.0 True False 559627.8874056243 621372.4812988741 549644.7499563111 550991.0056128757 553590.5491459849 569280.0481841542 548021.6926324198 609478.3354881938 580705.5215751036 579539.6995053303 0.9656420222519667 1.0721827716535217 0.948416045398553 0.9507390194031184 0.9552245508262946 0.9822968964336123 0.9456154480878308 1.0516593358633028 1.0020116345278303 1.0 19.14454796624272 -7.760335885798379 24.999988926774236 1.0201266098264745 0.9757388303333683 0.22206671296126534 0.03724744023527446 45.910294196522266 1040201.4420386506 0.019234715798797784 0.010300331531008613 1.736457323404881e-08 7.760335885798379 -0.04438777949310624 TSVS(ph)PAPDKTK ddPTM_A459_Selumetinib_30min_R1 1 TSVSPAPDKTK 11 1 O75362 O75362 ZNF217 Zinc finger protein 217 1 T(0.147)S(0.003)VS(0.85)PAPDKTK 151.16 0.0028518000000000003 7626800.0 2210.1 2612.8 3708.8 3366.1 3032.2 2821.6 2231.2 2671.4 1666.0 1942.1 True False 2261.5910298940094 2306.8921613422353 3205.165330980137 2778.2738245226765 2757.9380453783906 2793.217265807819 2062.898787650575 2600.545794069868 2827.080320174307 2191.387452655972 1.0320361317908207 1.0527084831786688 1.4626191854368158 1.2678149731830377 1.2585351084472791 1.2746341421378617 0.9413665233641507 1.1867120033556795 1.2900869340781669 1.0 11.097628870134448 TSVS(ph)PAPDKTK ddPTM_A459_Selumetinib_30min_R2 1 TSVSPAPDKTK 11 1 O75362 O75362 ZNF217 Zinc finger protein 217 1 T(0.004)S(0.122)VS(0.874)PAPDKTK 124.48 0.015688 0.0 11980.0 11935.0 13347.0 15016.0 14986.0 10122.0 7432.1 7453.3 7142.3 12115.0 True False 11314.199559739736 12850.376122926407 12488.26855111483 12970.79489595517 13103.324703460179 11516.213621632456 7777.707376426764 7474.987869039758 8570.959572535914 11765.208471449761 0.9616658801410555 1.092235310076314 1.061457481303429 1.10247046853704 1.1137350209524617 0.9788363418785538 0.6610768857433056 0.635346826805412 0.7285004420733194 1.0 13.522239263907842 -7.123319851534693 4.1837603159439825 0.7272461487250279 1.06786834264954 0.6710411117917456 0.10179671370651483 0.12276468467284012 3.58617227696011 0.038682567984841626 0.029673788528108442 7.528009326421974e-08 7.123319851534693 0.340622193924512 TSVSQNVIPSS(ph)AQK ddPTM_A459_Selumetinib_30min_R1 2 TSVSQNVIPSSAQK 14 0 Q03188;H0Y8J2;Q03188-2 Q03188 CENPC Centromere protein C 1 TSVSQNVIPS(0.16)S(0.84)AQK;TSVSQNVIPS(0.218)S(0.782)AQK 235.22 4.1692e-14 19691300.0 5495.5 7442.8 6735.1 7175.5 5278.2 6648.0 6721.6 5711.0 3635.8 5429.4 True False 5623.534457618447 6571.393515936151 5820.510413256122 5922.433625816961 4800.787741941896 6581.1271559010465 6214.584300408791 5559.52572805758 6169.6870516745175 6126.3163768345285 0.9179307942506442 1.0726500415134606 0.9500832237892982 0.9667201726981468 0.783633662814924 1.0742388657540274 1.0144079930164938 0.9074826349288526 1.0070794050082015 1.0 12.580804157557878 TSVSQNVIPSS(ph)AQK ddPTM_A459_Selumetinib_30min_R2 2 TSVSQNVIPSSAQK 14 0 Q03188;H0Y8J2;Q03188-2 Q03188 CENPC Centromere protein C 1 TSVSQNVIPS(0.012)S(0.988)AQK;TSVSQNVIPS(0.062)S(0.938)AQK 264.85 2.3247999999999998e-36 53021000.0 100374.0 87804.0 97614.0 99714.0 94099.0 81373.0 83831.0 88868.0 68189.0 96750.0 True False 94795.61490895806 94538.28446564158 91333.62151408714 86132.78118375574 82277.44236426656 92581.39211945246 87729.30760797512 89126.59116711059 81828.70535984948 93956.57611331096 1.0089300699360864 1.0061912468120282 0.9720833313885282 0.9167296717994514 0.875696473496869 0.9853636216777414 0.9337218451018713 0.9485934338393148 0.870920469272578 1.0 16.519706520375628 -5.519558724770047 3.3152292490357027 0.9308693435517851 1.0063805508500736 0.37486647012694885 0.038720808735930944 0.24110136617885142 5.499066177415545 0.010494214403614458 0.021992597803250167 3.0230217735570133e-06 5.519558724770047 0.07551120729828853 TSVTT(ph)SPQSDMMR ddPTM_A459_Selumetinib_30min_R2 2 TSVTTSPQSDMMR 13 0 O60318;O60318-2 O60318 MCM3AP Germinal-center associated nuclear protein 1 T(0.01)S(0.002)VT(0.181)T(0.732)S(0.075)PQSDMMR;TSVT(0.016)T(0.701)S(0.283)PQSDMMR 166.64 0.00076406 10773600.0 67176.0 66358.0 74576.0 81083.0 84143.0 64658.0 63128.0 64599.0 59647.0 69899.0 True False 63442.62684683448 71447.44522540015 69777.86135220948 70039.35552402312 73572.20409203581 73564.05259311522 66063.5770857589 64786.97239505988 71578.06667642771 67880.83425058737 0.9346176656083968 1.0525422383827276 1.027946431751547 1.0317986851114322 1.0838435458886422 1.0837234604623127 0.9732287149253361 0.9544221592194011 1.0544665142474785 1.0 16.050716675157624 -9.997106694225195 8.647522437806318 0.9999998861279211 1.0234492244762987 0.016403682679678733 0.04935256106838978 0.0 0.0 0.04952298488904758 0.01201108809373003 1.0066843237829092e-10 9.997106694225195 0.02344933834837759 TSYAQHQQVR ddPTM_A459_Selumetinib_30min_R1 4 TSYAQHQQVR 10 0 D6RAT0;P61247;D6RG13;D6R9B6;D6RB09;H0Y9Y4;D6RAS7;H0Y8L7;E9PFI5 D6RAT0 RPS3A 40S ribosomal protein S3a 0 ;;; 185.33 0.00016875 9837900.0 12639.8 13691.1 12036.0 12882.1 15603.0 11863.3 14090.9 13408.100000000002 5478.97 9189.5 False True 12934.282747230583 12088.13964718029 10401.577309015565 10632.483061965951 14191.711404933394 11743.965973014576 13028.012068351321 13052.473632353149 9297.411921863992 10369.061838310105 1.2473918035133007 1.1657891365368065 1.0031358160663415 1.0254045378225634 1.3686591541483453 1.1325967726052781 1.2564311286308771 1.2587902199723378 0.8966492887054895 1.0 13.33999774887463 -11.2831380357166 6.812838725351565 0.9963904258947713 1.155157362934231 0.09968039147875407 0.13508557923804226 0.007544553828988302 0.000265489150824673 0.13323909140412823 0.031681435658864075 5.2102908143115595e-12 11.2831380357166 0.15876693703945977 TSYAQHQQVR ddPTM_A459_Selumetinib_30min_R2 2 TSYAQHQQVR 10 0 D6RAT0;P61247;D6RG13;D6R9B6;D6RB09;H0Y9Y4;D6RAS7;H0Y8L7;E9PFI5 D6RAT0 RPS3A 40S ribosomal protein S3a 0 ; 160.75 0.00061375 13192700.0 16459.8 13977.099999999999 18967.6 23182.3 24000.0 18750.6 17403.5 17617.300000000003 18441.9 18942.4 False True 15545.03020980001 15049.098626539979 17747.24526636141 20024.83074830191 20984.905437277732 21333.32494900033 18212.79723438101 17668.563426298977 22130.795309739195 18395.483693734197 0.8450460161096445 0.8180865954433124 0.9647610012237086 1.0885732107779635 1.140763993306984 1.1597044853061846 0.9900689504883521 0.9604837644099121 1.2030559064493263 1.0 14.167063990808813 -5.492090469898401 2.824516676733187 1.0780984655209636 0.831200652651366 0.6369762786859863 0.07415912972037461 0.1716199426979613 2.7135401262354435 0.021503822147359932 0.04883835884152004 3.2203978653838905e-06 5.492090469898401 -0.24689781286959755 TT(ph)HSPYEER ddPTM_A459_Selumetinib_30min_R2 1 TTHSPYEER 9 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 T(0.203)T(0.797)HSPYEER 143.4 0.0047632 37967000.0 25563.0 19117.0 29411.0 30274.0 27130.0 23078.0 24645.0 23670.0 22848.0 27204.0 True False 24142.310796796908 20583.2124291566 27518.728280275605 26150.62897443706 23721.686854722695 26256.785018774313 25791.041333141056 23738.875781220566 27418.23842645934 26418.54983551954 0.9138393646549726 0.7791196926896655 1.041644164861649 0.989858608335789 0.897917826769926 0.9938768472246824 0.9762474281788622 0.898568465302506 1.0378404036998172 1.0 14.689263656031075 -5.261286948922754 24.999999938421364 0.9737260858754297 0.8464795294462677 0.47854671417031247 0.05527817245965901 10.958483163443718 1796915.5660889302 0.01374591393744852 0.0319979824128997 5.479148246510448e-06 5.261286948922754 -0.12724655642916205 TT(ph)KSPSDSGYSYETIGK ddPTM_A459_Selumetinib_30min_R1 1 TTKSPSDSGYSYETIGK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.277)T(0.352)KS(0.173)PS(0.109)DS(0.067)GYS(0.023)YETIGK 106.0 0.003594 973740000.0 9470.7 9989.6 12046.0 13250.0 11038.0 9415.4 9112.6 8925.8 5442.0 7286.1 True False 9691.348883225744 8820.012987960956 10410.219363941627 10936.13623330426 10039.614848917181 9320.689624499204 8425.229245403647 8689.058788915489 9234.676532045962 8221.341907624059 1.1788037758457017 1.0728191440112373 1.2662433311875416 1.3302130426132306 1.2211649827635738 1.1337187686909926 1.0247997638427508 1.0568905765684908 1.123256596770679 1.0 13.005158178017902 -6.9794743871663885 3.4563273312521288 1.0568776711529009 1.2148008544549531 0.5576080999813484 0.06809564386911518 0.20841550326937092 5.269397849899069 0.029085922659307706 0.024101142441490808 1.0483966217127073e-07 6.9794743871663885 0.15792318330205224 TT(ph)PDQELVPASEPVWERPWSVEEIR ddPTM_A459_Selumetinib_30min_R2 1 TTPDQELVPASEPVWERPWSVEEIR 25 1 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 T(0.472)T(0.528)PDQELVPASEPVWERPWSVEEIR 85.0 0.008960899999999999 0.0 3199.0 1003.7 1024.1 1256.9 3285.6 2225.7 2772.2 2096.1 2037.3 763.25 True False 3021.212386611639 1080.6805625958307 958.2105209557731 1085.7080517265629 2872.8335543633207 2532.2699721070285 2901.1127930100865 2102.1993039719655 2444.8169269181394 741.2129893383427 4.076038102500847 1.4579892394499452 1.2927600227447946 1.4647720255088081 3.875854303265527 3.416386394371617 3.914006951766749 2.8361609067975615 3.298400003891661 1.0 9.533744353775912 -6.256973526091146 24.984145064427143 3.2094489984492043 1.9732448151841888 0.15804497807961615 1.06869430069771 565.6733288920663 3164647.935909964 0.3117682643356991 0.3887386691810686 5.533838415965879e-07 6.256973526091146 -1.2362041832650155 TT(ph)PNSGDVQVTEDAVRR ddPTM_A459_Selumetinib_30min_R1 1 TTPNSGDVQVTEDAVRR 17 1 P35269;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 T(0.426)T(0.531)PNS(0.043)GDVQVTEDAVRR 98.443 0.0064744 3962100.0 1202.4 1176.3 1525.2 1740.7 1746.0 1587.0 1415.8 1242.4 672.43 933.23 True False 1230.4135805368799 1038.578249152966 1318.086217323906 1436.7194219858663 1588.0746082813378 1571.03622088071 1309.0050661328803 1209.4475161160467 1141.0645976559476 1053.0191609299898 1.1684626701856227 0.9862861832786879 1.2517210191691273 1.3643810818380606 1.5081155853601047 1.4919350750400646 1.2430971008892304 1.1485522400636137 1.0836123785707747 1.0 10.040315972808406 -7.979473225826315 2.080430515896391 1.0365856361107733 1.2950634657985753 0.33157351509796185 0.14360380110500756 0.47518214638150913 3.800996528127196 0.13901781409949163 0.04759009233642235 1.0483994252174461e-08 7.979473225826315 0.2584778296878021 TT(ph)PPPGRPPAPSSEEEDGEAVAH ddPTM_A459_Selumetinib_30min_R1 1 TTPPPGRPPAPSSEEEDGEAVAH 23 1 Q96KN1 Q96KN1 FAM84B Protein FAM84B 1 T(0.461)T(0.533)PPPGRPPAPS(0.003)S(0.003)EEEDGEAVAH 81.312 0.00069873 9937000.0 984.76 1130.9 1491.9 1532.8 1151.7 1262.0 1243.5 1089.5 845.54 899.14 True False 1007.7029919906004 998.4937022588538 1289.3081744200986 1265.1252542195305 1047.5289383491502 1249.3054258043203 1149.7017938524064 1060.6029208052419 1434.8196242017896 1014.5533773652702 0.9932478807645786 0.9841706947463698 1.2708135453339566 1.2469775198077595 1.0325025392646323 1.2313846207369454 1.1332097645154047 1.0453889804788383 1.4142376894234228 1.0 9.9866290543741 -5.240868088765444 24.059697879654955 1.1718931190962139 0.9887091942930945 0.27112747490341116 0.12008785571457213 638.7559231657186 747068.7793711742 0.029004202758263424 0.07650311635733024 5.742908690142094e-06 5.240868088765444 -0.1831839248031194 TT(ph)SPLEEEER ddPTM_A459_Selumetinib_30min_R1 1 TTSPLEEEER 10 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 T(0.003)T(0.498)S(0.498)PLEEEER 160.91 0.0010154 59174000.0 3088.4 3702.0 2645.1 2701.5 3016.3 3124.2 3864.4 2953.2 1812.1 2925.0 True False 3160.3537110197103 3268.5681189868906 2285.909948494272 2229.7337384355837 2743.4761975710194 3092.7733845466378 3572.9051967537116 2874.871542654463 3075.0013494524965 3300.4522419127343 0.9575517169696018 0.990339468476185 0.6926050677132364 0.6755843063323257 0.8312425075362015 0.9370756362631871 1.082550188541156 0.8710538229113622 0.9316909090223403 1.0 11.688448006848999 -6.798872425974216 4.61684025710015 0.9661841512879066 0.8215747381413118 0.29458119575652464 0.10491109992202267 0.29040840745199437 13.936679765207733 0.04140344033617839 0.037542569541604634 1.5890134528284832e-07 6.798872425974216 -0.1446094131465948 TT(ph)SPPEVSGYSYEK ddPTM_A459_Selumetinib_30min_R2 2 TTSPPEVSGYSYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.306)T(0.476)S(0.219)PPEVSGYSYEK;T(0.148)T(0.754)S(0.098)PPEVSGYSYEK 158.52 0.00071365 449650000.0 92981.0 103206.0 106787.0 113551.0 121832.0 93343.0 94754.0 88763.0 87918.0 116510.0 True False 87813.48825243418 111121.56834040576 99916.44068089442 98085.15791359903 106526.37496810088 106200.15096661117 99160.24875148895 89021.28563449427 105504.05663416714 113146.05357066545 0.7761073893539752 0.9821073279502825 0.8830749065277079 0.8668897837637782 0.9414943924806866 0.9386111809925725 0.8763915808124793 0.7867820646426343 0.9324590059013813 1.0 16.78782674005513 -4.736404390203787 24.88481364164571 0.9036460762254013 0.7761067650279495 0.3129794213538656 0.05924499426971694 3071.2555509048975 3052664.4613457783 0.014675946023533684 1.0401040472565921 1.834829059709141e-05 4.736404390203787 -0.12753931119745177 TTAGS(ph)VDWTDQLGLR ddPTM_A459_Selumetinib_30min_R1 2 TTAGSVDWTDQLGLR 15 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 TTAGS(0.98)VDWT(0.019)DQLGLR;T(0.385)T(0.039)AGS(0.422)VDWT(0.153)DQLGLR 165.89 8.3283e-05 24134000.0 3372.2 3809.8 4478.5 4559.5 3913.7000000000003 3751.9 4052.2999999999997 3816.5 2142.8999999999996 3244.0 True False 3450.765698841038 3363.7468448720315 3870.3442986395976 3763.268917415152 3559.706526019854 3714.1592924526376 3746.6317484745546 3715.274022260859 3636.3447887764232 3660.398999235865 0.9427293853925243 0.9189563338789672 1.0573558509461838 1.0281034712884474 0.9724913941794238 1.0146870035829414 1.0235582922125952 1.0149915413692467 0.9934285277467119 1.0 11.837785201708142 -5.247008083191023 24.997309452766004 1.0131314270229617 0.9308428470391346 0.6931704495913146 0.0218846824287887 444.4011492265556 769770.7656121294 0.00570898697594211 0.01495980083425181 5.662287501575289e-06 5.247008083191023 -0.0822885799838271 TTAGS(ph)VDWTDQLGLR ddPTM_A459_Selumetinib_30min_R2 2 TTAGSVDWTDQLGLR 15 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 T(0.002)T(0.001)AGS(0.995)VDWT(0.002)DQLGLR;TTAGS(0.923)VDWT(0.077)DQLGLR 145.7 0.00036164 3103300.0 12709.400000000001 11865.1 15898.8 14689.7 15152.2 12859.900000000001 12207.2 9885.099999999999 13068.4 15350.099999999999 True False 12003.062427759287 12775.115017690336 14875.888517304595 12688.937518854065 13248.64517361332 14631.234494450813 12774.858988107906 9913.864004433597 15682.445161604575 14906.9027286505 0.8052016335150465 0.8569932500556974 0.9979194731521057 0.8512122034892204 0.8887590812644083 0.9815073433282782 0.8569760748190242 0.6650519014509652 1.0520257257373467 1.0 13.863692913348183 -5.001846508213938 20.013673216005934 0.8992924873402339 0.8181485964389307 0.08646149315989726 0.10450149813887423 15.756472841544081 171111.34868869322 0.02552077282608128 0.0908710690856334 9.957572835723271e-06 5.001846508213938 -0.08114389090130325 TTAGSVDWT(ph)DQLGLR ddPTM_A459_Selumetinib_30min_R2 1 TTAGSVDWTDQLGLR 15 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 T(0.001)TAGS(0.234)VDWT(0.765)DQLGLR 165.78 1.3073e-05 0.0 6219.6 7505.3 8316.9 8723.0 8281.8 6808.8 6311.3 7621.9 4517.6 7497.3 True False 5873.939531031494 8080.932376656856 7781.799708756041 7534.91235198568 7241.3662437686135 7746.650395867522 6604.787955603696 7644.078467126534 5421.246232290474 7280.833468675215 0.8067674609374478 1.1098911149971986 1.068806166524226 1.0348969502466447 0.994579298499766 1.0639785169096945 0.9071472358240149 1.0498905791506055 0.7445914338811127 1.0 12.829887896115936 -8.235236612697959 24.939931228533215 0.8722956118365983 1.0095723790991307 0.21185048852459154 0.10161777985355482 881.4035153513439 838927.4208529931 0.06440839683699656 0.024326062428445885 5.817861621657745e-09 8.235236612697959 0.13727676726253235 TTAPTEGKS(ph)PLKK ddPTM_A459_Selumetinib_30min_R1 1 TTAPTEGKSPLKK 13 2 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 1 TTAPTEGKS(1)PLKK 174.59 0.0039025 24564000.0 2618.1 3779.9 3288.1 3203.1 2812.2 3171.5 2855.6 3345.7 1739.7 2803.9 True False 2679.096636064208 3337.3475507721623 2841.594080240451 2643.738714633728 2557.837006534234 3139.5975894915996 2640.1997929432505 3256.9611676347813 2952.143837339279 3163.8078772988433 0.8467949824916466 1.0548515207634799 0.8981563326362636 0.8356192338995205 0.8084678671190466 0.9923477376799776 0.8345006698691728 1.0294434093183527 0.9330983270260151 1.0 11.627446279263006 -7.770572808167049 24.99987331054605 0.9859531447199833 0.90006375597577 0.23500756455393945 0.0755252126220332 327.2730725387168 895791.4269278797 0.040968806996817694 0.020114128967309474 1.6960052482331855e-08 7.770572808167049 -0.08588938874421326 TTATPLS(ph)PLKPPR ddPTM_A459_Selumetinib_30min_R2 1 TTATPLSPLKPPR 13 1 E5RIF5;Q9H898 E5RIF5 ZMAT4 Zinc finger matrin-type protein 4 1 TTAT(0.004)PLS(0.996)PLKPPR 79.471 0.021457 8657000.0 66789.0 53036.0 59865.0 62970.0 48638.0 52035.0 59358.0 46537.0 35646.0 61585.0 True False 63077.134757550724 57103.69066238164 56013.351076083745 54393.37737069106 42527.65961076308 59202.34892330022 62118.26461564565 46672.414965384916 42776.196032456704 59806.881032953635 1.0546802252201577 0.9548013485424439 0.9365703428878083 0.9094835983959817 0.7110830539270274 0.989891930506787 1.0386474523126936 0.7803853696979848 0.7152387032001717 1.0 15.86802386164861 -4.787922496463353 1.0590816261542104 0.8741945195823646 1.1386583219478195 0.19915443470993288 0.10922545125597354 3.149967581597323 2.8843362892416056 0.03712098381213568 0.9441661250291362 1.6295868202924263e-05 4.787922496463353 0.26446380236545486 TTCMSSQGS(ph)DDEQIKR ddPTM_A459_Selumetinib_30min_R1 2 TTCMSSQGSDDEQIKR 16 1 E7EW69;E7EX04;B5ME97;Q9P0V9;Q9P0V9-2;C9JEW2;C9JNR7 E7EW69 SEPT10 Septin-10 1 TTCMS(0.01)S(0.232)QGS(0.758)DDEQIKR;TTCMS(0.014)S(0.048)QGS(0.938)DDEQIKR 208.38 1.1364e-07 13440100.0 3495.9 3881.9 3762.3 4209.0 3513.1 3473.7 3847.7 3465.8 2472.1099999999997 2959.2 True False 3577.347668162739 3427.4053433536524 3251.400324834599 3473.977162715293 3195.340725288182 3438.7577318672456 3557.4648911989575 3373.8757254950046 4194.990114229351 3339.0421450489407 1.0713694265486144 1.0264636367156177 0.9737524067061282 1.0404112951573345 0.9569632806300945 1.0298635304637174 1.0654147916263619 1.0104322074813326 1.2563453625314647 1.0 11.7052185877275 TTCMSSQGS(ph)DDEQIKR ddPTM_A459_Selumetinib_30min_R2 3 TTCMSSQGSDDEQIKR 16 1 E7EW69;E7EX04;B5ME97;Q9P0V9;Q9P0V9-2;C9JEW2;C9JNR7 E7EW69 SEPT10 Septin-10 1 T(0.001)T(0.001)CMS(0.064)S(0.046)QGS(0.89)DDEQIKR;TTCMS(0.053)S(0.378)QGS(0.569)DDEQIKR;TTCMS(0.073)S(0.278)QGS(0.649)DDEQIKR 222.51 1.7416e-50 16530000.0 64783.0 60281.0 66618.0 71931.0 66559.0 45695.0 55707.0 52465.0 44054.0 60548.0 True False 61182.62020689643 64904.35886603492 62331.87040819416 62133.87371210383 58197.263374990376 51989.071472090014 58297.485881326356 52617.66446395171 52866.03097160538 58799.8219174032 1.0405239031648832 1.1038189700167262 1.0600690338102123 1.0567017328621167 0.9897523747051608 0.8841705599911455 0.9914568442608129 0.894860949372676 0.899084882363537 1.0 15.843524165235777 -6.404677155406668 2.7850052026441334 0.9308298906760991 1.0692588045921712 0.7092960041586454 0.03941603184090346 0.1403374516917425 2.107227614446832 0.012720370749748182 0.014577693911852256 3.938427403551705e-07 6.404677155406668 0.13842891391607204 TTDEELS(ph)ELEDR ddPTM_A459_Selumetinib_30min_R1 1 TTDEELSELEDR 12 0 H7C3K9;H7C052;Q9BV36-5;H7C190;Q9BV36;Q9BV36-4;Q9BV36-2;H7C2D8 H7C3K9;Q9BV36;Q9BV36-2 MLPH Melanophilin 1 TTDEELS(1)ELEDR 123.95 0.0031725 9141500.0 654.62 862.84 965.22 796.57 666.9 730.27 811.49 574.74 514.78 561.34 True False 669.8713723312142 761.8182916765663 834.148425573945 657.4640029708062 606.5790127507582 722.9241468321081 750.2786559656527 559.496028181372 873.5440619563801 633.3934569146298 1.057591241302483 1.2027568067840744 1.3169514406372742 1.0380025176979695 0.9576654228566088 1.1413508285254443 1.1845380588874268 0.8833309249937233 1.3791491724773506 1.0 9.30695815387974 -5.7928479232162085 24.999679338503054 1.079958154585902 1.1934658364481998 0.11066895451649317 0.14134696101118693 404.696369618662 322117.0557574452 0.03843508395306701 0.0570144037407309 1.6112097332933614e-06 5.7928479232162085 0.11350768186229776 TTDEELS(ph)ELEDR ddPTM_A459_Selumetinib_30min_R2 2 TTDEELSELEDR 12 0 H7C3K9;H7C052;Q9BV36-5;H7C190;Q9BV36;Q9BV36-4;Q9BV36-2;H7C2D8 H7C3K9;Q9BV36;Q9BV36-2 MLPH Melanophilin 1 TTDEELS(1)ELEDR;TTDEELS(1)ELEDR 145.83 0.00067258 12891500.0 45770.0 38171.0 45911.0 52796.0 56101.0 51672.0 42100.0 47263.0 55419.0 44693.0 True False 43226.286631827024 41098.59296089018 42957.13624411723 45605.093721820034 49053.090830696565 58789.34896828609 44057.733419567376 47400.52750518913 66504.34853623727 43402.59696364044 0.9959377930320364 0.9469155266289621 0.9897365422650543 1.0507457367130517 1.1301879210543484 1.3545122430700531 1.0150944068272172 1.09211270341491 1.5322665736326748 1.0 15.405493747437518 -6.174032674772055 2.224094448813371 1.1956877218433517 0.9760353464348496 0.29557804218656647 0.14955190742748622 0.40208085875584854 3.9025207403786952 0.048584641001952644 0.06639327132765295 6.698342115771609e-07 6.174032674772055 -0.21965237540850213 TTDGSLQNT(ph)SSEGSR ddPTM_A459_Selumetinib_30min_R2 2 TTDGSLQNTSSEGSR 15 0 A8MQB8;Q06787-6;G3V0J0;Q06787-2;Q06787-4;Q06787-7 A8MQB8 FMR1 1 TTDGS(0.003)LQNT(0.495)S(0.495)S(0.007)EGSR;TTDGS(0.002)LQNT(0.728)S(0.263)S(0.007)EGSR 118.31 0.0047699 4980900.0 25584.0 21751.3 25722.7 28316.0 28789.0 22575.6 20796.7 25225.9 20521.9 28755.0 True False 24162.143700866578 23419.554768547056 24067.729486758184 24459.311952175445 25172.268443074543 25685.18397910745 21763.78775787927 25299.303192627456 24626.85342979502 27924.76843553758 0.8652585161679403 0.8386660330813306 0.8618774956833355 0.8759002606821288 0.9014315911404245 0.9197993544118349 0.77937218380591 0.9059807694029467 0.8819000052460392 1.0 14.769257696845802 -8.991667631247896 1.4212649007196199 0.9998975325824492 0.8672392462056622 0.5255463909082396 0.03736592178086496 1.7878005462876372 4.572829198933049 0.03601406227001902 0.010516437287575661 1.0193712218819263e-09 8.991667631247896 -0.132658286376787 TTDGSLQNTS(ph)SEGSR ddPTM_A459_Selumetinib_30min_R1 1 TTDGSLQNTSSEGSR 15 0 A8MQB8;Q06787-6;G3V0J0;Q06787-2;Q06787-4;Q06787-7 A8MQB8 FMR1 1 TTDGS(0.024)LQNT(0.384)S(0.566)S(0.026)EGSR 132.15 0.00064858 1841500.0 629.42 736.03 627.91 835.69 692.55 696.01 741.71 620.75 279.57 460.23 True False 644.0842613618785 649.8552654289359 542.6432708627417 689.752429344154 629.9089747796332 689.0087713265167 685.7622175458532 604.2856935198288 474.4098710150843 519.3050035198281 1.2402812547468283 1.2513941922843868 1.0449413488888568 1.328222190560538 1.212984605405563 1.3267901650406666 1.3205384367525537 1.163643118059724 0.9135476604299084 1.0 9.020438315678899 -8.123809545398647 4.118840129769275 0.9600033474062821 1.2438543512840112 0.6657787507494817 0.08072819894404135 0.14039636689348917 3.871394775725747 0.06162919800630631 0.021387729239393652 7.519525814481955e-09 8.123809545398647 0.2838510038777291 TTDLSIQS(ph)PSADLEVQAGQVNVK ddPTM_A459_Selumetinib_30min_R1 1 TTDLSIQSPSADLEVQAGQVNVK 23 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 T(0.005)T(0.001)DLS(0.007)IQS(0.823)PS(0.164)ADLEVQAGQVNVK 175.07 9.147599999999999e-14 5515500.0 3829.8 4142.7 4327.4 4699.9 4909.7 3970.5 3925.2 4132.0 2460.4 3160.1 True False 3919.0268885064397 3657.67075811102 3739.7628487067072 3879.1506930495616 4465.618501877937 3930.5603749255583 3629.1190038033515 4022.4059373724263 4175.119099493916 3565.7296169806564 1.0990813408406843 1.0257846642921333 1.048807186865003 1.0878981610317104 1.2523715989602366 1.1023158784130773 1.0177773958296847 1.128073737901212 1.1709017642872404 1.0 11.799981594739318 -5.999696064591208 24.691050666360276 1.1183071695131233 1.0569591049759082 0.10479029359179293 0.06928634347524353 19.357953547068558 1572119.9633175852 0.02000875063234304 0.029352467244587694 1.0007000820846663e-06 5.999696064591208 -0.061348064537215086 TTDLSIQSPS(ph)ADLEVQAGQVNVK ddPTM_A459_Selumetinib_30min_R1 1 TTDLSIQSPSADLEVQAGQVNVK 23 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 TTDLS(0.001)IQS(0.464)PS(0.535)ADLEVQAGQVNVK 170.68 1.2856e-12 7305400.0 3371.5 3481.0 3689.4 3597.7 3625.5 3524.7 3633.2 3331.7 1952.0 3032.9 True False 3450.0493902030003 3073.4429017270054 3188.3997444235633 2969.429232193112 3297.574165134011 3489.24471817154 3359.1447988938967 3243.3324931131906 3312.401431560772 3422.2022579477366 1.008137196505727 0.8980892039882298 0.9316806851549497 0.86769542194559 0.9635824877023884 1.0195904435712717 0.9815740116156504 0.9477325560115162 0.9679151557649864 1.0 11.740709312728798 -6.508627814112314 24.83647962988945 0.9812731132734689 0.9236159539837828 0.3374051771315706 0.03756329303036173 707.7398557425693 1233449.3043317224 0.011838246439156557 0.012911573822644741 3.100074893326595e-07 6.508627814112314 -0.057657159289686066 TTDLSIQSPS(ph)ADLEVQAGQVNVK ddPTM_A459_Selumetinib_30min_R2 1 TTDLSIQSPSADLEVQAGQVNVK 23 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 TTDLS(0.002)IQS(0.347)PS(0.65)ADLEVQAGQVNVK 112.8 8.594e-06 2839600.0 22760.0 25513.0 24556.0 23615.0 23710.0 15733.0 20535.0 22902.0 19666.0 18278.0 True False 21495.09031549886 27469.765062775157 22976.093694551277 20398.596261852785 20731.33782991063 17900.077940045783 21489.91818933055 22968.641028369806 23599.74951395089 17750.26664805271 1.2109728119412209 1.5475691496605612 1.2944083686242462 1.1491994270458246 1.1679451492738537 1.008439945999882 1.2106814289287364 1.293988506414329 1.3295433799322611 1.0 14.11555307678276 -5.569559377745369 4.852752953996047 1.1747081825091852 1.389334918608905 0.3272202581308076 0.12475728485484716 0.21308199554542806 11.122315989750376 0.03441811873380786 0.06279969962041292 2.694266940763858e-06 5.569559377745369 0.21462673609971983 TTEEQVQAS(ph)TPCPR ddPTM_A459_Selumetinib_30min_R2 2 TTEEQVQASTPCPR 14 0 Q14137 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 TTEEQVQAS(0.922)T(0.078)PCPR;TTEEQVQAS(0.5)T(0.5)PCPR 227.74 3.7126e-13 23921700.0 58642.0 58108.0 63019.0 65279.0 71718.0 65329.0 61304.0 67467.0 56112.0 75488.0 True False 55382.91240252569 62564.69675333117 58964.42614989931 56387.88758744394 62708.14367294519 74327.47675238359 64154.75747157149 67663.31780023682 67335.96790027514 73308.46529862139 0.7554777224829886 0.8534443668746089 0.8043331136412177 0.7691865783541966 0.8554011247883053 1.0139003244660936 0.87513436831937 0.9229946026643838 0.9185292261402918 1.0 16.161692182808594 -6.545786748049101 7.674616822067398 0.9369310698224532 0.8017100568996062 0.7139544753701949 0.044877287599213146 0.10357481512045169 25.934314276712087 0.014297200291972236 0.014478364015874528 2.8458581683282376e-07 6.545786748049101 -0.13522101292284705 TTEEQVQAST(ph)PCPR ddPTM_A459_Selumetinib_30min_R1 3 TTEEQVQASTPCPR 14 0 Q14137 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 TTEEQVQAS(0.002)T(0.998)PCPR;TTEEQVQAS(0.001)T(0.999)PCPR;TTEEQVQAS(0.028)T(0.972)PCPR 244.0 1.376e-19 31010000.0 7229.5 9395.3 9123.9 9735.0 7906.200000000001 7889.700000000001 8570.9 8153.200000000001 5153.5 6674.0 True False 7397.933283841793 8295.293908243533 7884.92449399527 8034.9649985824135 7191.085605952981 7810.336781274439 7924.390112528825 7936.9506506739735 8745.113103252275 7530.672910265152 0.9823734707369352 1.1015342197290388 1.047041159263103 1.0669650766042242 0.9549061141867846 1.0371366376340785 1.0522818089372854 1.0539497260404207 1.1612658267671812 1.0 12.878563068673188 -8.013815574938102 23.687536176012586 1.0896245283542023 1.0371617782305045 0.10055451757716194 0.053189332184996614 619.4434709933352 1062058.7568416086 0.0319631491013483 0.013197628312564396 9.686891270294784e-09 8.013815574938102 -0.05246275012369783 TTEEQVQAST(ph)PCPR ddPTM_A459_Selumetinib_30min_R2 2 TTEEQVQASTPCPR 14 0 Q14137 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 TTEEQVQAS(0.002)T(0.998)PCPR;TTEEQVQAS(0.029)T(0.971)PCPR 249.58 4.6486e-27 22552600.0 72419.0 68417.0 73610.0 80696.0 80460.0 62270.0 69967.0 70036.0 57909.0 85443.0 True False 68394.24189622642 73664.36390467154 68874.01274050811 69705.06559163543 70351.89547847367 70847.12726922067 73220.6041369803 70239.79316491603 69492.41811265032 82976.0385824251 0.824264969317453 0.8877787511089276 0.830047010162957 0.8400625865308475 0.8478579681601562 0.8538263392611103 0.8824307039464876 0.8465069478478732 0.8374998288646827 1.0 16.340407161681732 -11.108188188114111 3.0480982526421343 1.0080976419688148 0.8511569299601951 0.8405636905761489 0.0195888876035896 8819587.006205505 10207801.913203726 579847.4106199872 0.004849109948097941 7.794922684075765e-12 11.108188188114111 -0.1569407120086197 TTEINRLPSANQGS(ph)PFK ddPTM_A459_Selumetinib_30min_R1 2 TTEINRLPSANQGSPFK 17 1 E5RFE4;Q56NI9;E5RFP7;E5RIE3 E5RFE4 ESCO2 N-acetyltransferase ESCO2 1 TTEINRLPS(0.009)ANQGS(0.99)PFK;TTEINRLPSANQGS(1)PFK 101.53 0.018736000000000003 38989900.0 3646.2 3801.7 6301.200000000001 6591.8 4679.8 4690.4 3539.2 3526.8 2688.3 3322.2 True False 3731.1493657298497 3356.5951966376206 5445.531650014031 5440.66587341095 4256.512916285795 4643.218834542459 3272.2352945737316 3433.2578073390787 4561.8487543364845 3748.6367309683687 0.9953350066988215 0.8954175711153869 1.4526698746312798 1.451371862326464 1.1354829026567823 1.2386419831464963 0.8729134161069881 0.9158683686194848 1.2169354039163038 1.0 11.872150309855058 -7.245994456537793 24.397568290775006 0.9944183230081602 1.2018954572010874 0.20893645672722627 0.18383734720927475 988.5308711300396 1561534.1878902577 0.07665784199158408 0.05913940148602003 5.675518497606661e-08 7.245994456537793 0.20747713419292713 TTEINRLPSANQGS(ph)PFK ddPTM_A459_Selumetinib_30min_R2 2 TTEINRLPSANQGSPFK 17 1 E5RFE4;Q56NI9;E5RFP7;E5RIE3 E5RFE4 ESCO2 N-acetyltransferase ESCO2 1 TTEINRLPS(0.001)ANQGS(0.999)PFK;TTEINRLPSANQGS(1)PFK 105.52 0.0014554 20932400.0 91088.0 116217.0 91338.0 110228.0 90281.0 56711.0 53180.0 46315.0 29011.0 92058.0 True False 86025.69361415465 125130.47020344672 85461.41252129532 95214.756246094 78939.09365761957 64522.425478798425 55652.975374170856 46449.76898213899 34814.01063506705 89400.0463445911 0.9622555818659191 1.39966896349397 0.9559437160903208 1.065041464062448 0.8829871670686842 0.7217269802086872 0.622516180356969 0.5195720906351554 0.38941826160667725 1.0 16.447987958845005 -6.543764261505598 1.1809048142333687 0.5868607675670949 1.1430647181720177 0.5626454190998516 0.18532252413261055 0.30476734545179235 0.8949092803027305 0.08208991498537191 0.0913050196916547 2.859142087276971e-07 6.543764261505598 0.5562039506049228 TTFDEAMADLHTLS(ph)EDSYK ddPTM_A459_Selumetinib_30min_R1 1 TTFDEAMADLHTLSEDSYK 19 0 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 1 TTFDEAMADLHT(0.058)LS(0.702)EDS(0.239)Y(0.001)K 91.238 0.0016643 2863500.0 611.91 1124.3 515.39 561.28 694.42 686.63 953.8 907.5 398.91 747.73 True False 626.1663124304077 992.6664333271101 445.4028688346238 463.26298453049196 631.609833609809 679.7231256101587 881.8540980912147 883.4301520245582 676.921134766346 843.7084290069768 0.7421596026572704 1.1765515185091289 0.5279108913950896 0.5490794788855442 0.748611501195025 0.805637471715407 1.0452119094378782 1.0470799172462137 0.8023164300528144 1.0 9.720600704463513 -7.112424812567262 4.563498486443468 0.9764094795179417 0.7513928465066269 0.26623450201873655 0.17684658328704583 0.34915105603329505 11.61600243824738 0.07362177825028639 0.05676978829294372 7.719251439144626e-08 7.112424812567262 -0.2250166330113148 TTFDEAMADLHTLSEDS(ph)YK ddPTM_A459_Selumetinib_30min_R1 1 TTFDEAMADLHTLSEDSYK 19 0 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 1 TTFDEAMADLHT(0.048)LS(0.326)EDS(0.625)Y(0.001)K 94.384 0.0012052 2931200.0 569.44 1080.2 568.21 560.6 323.77 661.42 891.48 777.37 404.47 569.07 True False 582.7068440626417 953.7296818286446 491.05020295411504 462.7017337653108 294.48506066623617 654.7667153213098 824.2349458653342 756.7516223463707 686.3560486800127 642.1156777112066 0.9074795465821283 1.4852926270670928 0.7647379124964557 0.7205893732646289 0.4586168363244383 1.0197021160660604 1.2836237682332938 1.1785284935633078 1.0688978209136692 1.0 9.326689413332453 -6.997695122002637 24.9996142823743 1.1482146537910538 0.8729544029748398 0.19891781287477595 0.2510507751802687 129.70052538454146 1406761.5063170427 0.09731158579213517 0.08530394312080267 1.005321285732435e-07 6.997695122002637 -0.27526025081621397 TTFDEAMADLHTLSEDSYK ddPTM_A459_Selumetinib_30min_R1 2 TTFDEAMADLHTLSEDSYK 19 0 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 0 ; 101.92 0.0015977 25271000.0 4436.9 4568.1 4015.5 4395.4 4364.7 4191.3 4592.1 4572.299999999999 2627.9 3845.3 False True 4540.271137295478 4033.264728347927 3470.2171555626455 3627.825901876645 3969.9136556503736 4149.139327395915 4245.71419987908 4451.027751076463 4459.354365777947 4338.881711393859 1.046415053301124 0.929563190846299 0.7997952897517097 0.8361200288890133 0.9149624073008076 0.9562692885819674 0.9785272985732425 1.0258467612491275 1.0277658305520816 1.0 12.083107539931358 -7.117568216582942 1.6852678473551064 1.0170112166015766 0.8968393757354862 0.3848528914844447 0.06155800277767633 0.41142716195382467 2.3145002092729254 0.03421119305116871 0.023545464337188484 7.628370595107617e-08 7.117568216582942 -0.12017184086609034 TTFS(ph)PPVVAATVK ddPTM_A459_Selumetinib_30min_R1 1 TTFSPPVVAATVK 13 0 A0A1B0GV05;Q684P5-3;Q684P5-2;Q684P5 A0A1B0GV05 RAP1GAP2 Rap1 GTPase-activating protein 2 1 T(0.006)T(0.001)FS(0.992)PPVVAATVK 95.264 0.015138 7265100.0 1437.0 1378.8 1398.5 1721.1 1418.4 1416.0 1244.9 1289.7 916.92 1331.3 True False 1470.4793040847435 1217.3694550132705 1208.5913814106232 1420.5421940482986 1290.105970438859 1401.7563256251317 1150.9961907252602 1255.492966463992 1555.9462708128588 1502.1853229601434 0.9788934039024417 0.8103989810087968 0.8045554452822263 0.9456504283033719 0.858819448386455 0.9331447353399044 0.7662145097098642 0.8357776815379677 1.0357884922925331 1.0 10.55284709220312 -8.26376818840263 24.994629284443427 1.0178942661778976 0.8639715800953585 0.4646570825814136 0.06487062742177489 182.00888479558392 1953397.6570794918 0.05282715905889089 0.016181559980468156 5.447933673863374e-09 8.26376818840263 -0.15392268608253912 TTGIVMDSGDGVT(ph)HTVPIYEGYALPHAILR ddPTM_A459_Selumetinib_30min_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 T(0.015)T(0.015)GIVMDS(0.098)GDGVT(0.843)HT(0.029)VPIYEGYALPHAILR;T(0.001)T(0.001)GIVMDS(0.015)GDGVT(0.775)HT(0.208)VPIYEGYALPHAILR 110.27 3.4916e-11 763610000.0 4229.09 5108.6 5697.7 6710.9 7031.0 5288.2 5976.9 5108.3 1362.13 2541.19 True False 4327.61956862335 4510.4827370762905 4923.983635225817 5538.967294194837 6395.047291423872 5235.005509301432 5526.057620970199 4972.811289903089 2311.435123960999 2867.3764897867404 1.5092610210196757 1.573034707211314 1.7172434986352405 1.9317195749926774 2.2302782052521817 1.8257126428803154 1.9272173154287098 1.7342721849103742 0.8061149738076114 1.0 11.48551562917354 -8.226617818698394 5.888651790837663 0.8998707225238465 1.8216383842336998 0.7722378771372053 0.1961816583359293 0.0849820708955204 8.95873082158541 0.16029145850156867 0.05587588206538019 5.934473314618613e-09 8.226617818698394 0.9217676617098534 TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_A459_Selumetinib_30min_R1 4 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ;;; 166.85 1.0068999999999998e-27 283786000.0 7620.5 10355.7 9866.7 11911.3 9190.0 9255.6 8912.2 7482.699999999999 4503.25 5386.700000000001 False True 7798.042823088232 9143.24982976568 8526.856333903606 9831.215057792984 8358.76612262628 9162.497067412414 8239.94557874662 7284.2344887649215 7641.686345633221 6078.135415901304 1.2829662864514986 1.504285311881269 1.402873702286409 1.61747219913414 1.3752188048917942 1.5074519470958088 1.3556699571368054 1.1984324123000423 1.257241871518926 1.0 12.56941310194957 -8.203334212907102 0.8372394774519898 1.018240419975118 1.4591941424676511 0.6821491045173063 0.09470378847322805 0.31309576703183345 0.46149888911293135 0.08634080873568707 0.03298993201840614 6.261318371775616e-09 8.203334212907102 0.44095372249253306 TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_A459_Selumetinib_30min_R2 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ; 120.92 3.8117999999999996e-16 30887300.0 73342.0 63843.0 83098.0 76514.0 110834.0 61346.0 43489.0 51309.0 40537.0 86007.0 False True 69265.94525128823 68739.5528123998 77751.56515026142 66092.66120598798 96910.04205146823 69795.85465645754 45511.324671818664 51458.30069533778 48645.532698414885 83523.75443697727 0.8292963566856032 0.822994048528639 0.9308916448305584 0.7913037632408887 1.160269227655368 0.8356407722203377 0.5448907915910218 0.6160918057648566 0.5824155418578592 1.0 16.349898942820623 -7.071395488307723 6.72959991766968 0.6569007224515746 0.9068095140952653 0.3161229489659104 0.15127207606446436 0.2634083139749582 20.7863409160954 0.05605121920152673 0.043551918519989755 8.48407524668771e-08 7.071395488307723 0.24990879164369073 TTGT(ph)PPDSSLVTYELHSRPEQDK ddPTM_A459_Selumetinib_30min_R1 1 TTGTPPDSSLVTYELHSRPEQDK 23 1 Q13561;Q13561-3;Q13561-2;H0YI98;F8VW18;F8W1I6 Q13561 DCTN2 Dynactin subunit 2 1 T(0.202)T(0.202)GT(0.596)PPDSSLVTYELHSRPEQDK 96.181 4.1658e-05 14025000.0 4167.2 5160.9 3408.4 3617.3 3705.2 4147.0 4542.5 4429.5 2221.6 4461.8 True False 4264.287652040325 4556.65942876268 2945.5580010010503 2985.6064601306784 3370.065314206189 4105.284945174735 4199.855567812268 4312.015270956235 3769.8929407558426 5034.5154916123865 0.8470105334157223 0.9050840018973375 0.5850727852379072 0.5930275644408611 0.6693921827871604 0.815428009311766 0.8342124629091558 0.8564906152618157 0.7488094826675114 1.0 12.297637228438964 -6.89902926647791 5.320973565639063 0.8448849971727852 0.7161140957561692 0.26414803865230685 0.11000369322475402 0.346631393219278 15.236728860136658 0.04273305674672288 0.0376010828742641 1.26174250472055e-07 6.89902926647791 -0.12877090141661596 TTGT(ph)PPDSSLVTYELHSRPEQDK ddPTM_A459_Selumetinib_30min_R2 1 TTGTPPDSSLVTYELHSRPEQDK 23 1 Q13561;Q13561-3;Q13561-2;H0YI98;F8VW18;F8W1I6 Q13561 DCTN2 Dynactin subunit 2 1 T(0.209)T(0.209)GT(0.582)PPDSSLVTYELHSRPEQDK 105.65 1.2016e-05 18328000.0 101050.0 80597.0 96192.0 92006.0 97082.0 73630.0 86304.0 81284.0 67418.0 98584.0 True False 95434.04553520033 86778.53073979876 90003.11144593095 79474.62408079731 84885.69123590812 83771.86415340813 90317.3070081317 81520.52298270934 80903.48381630956 95737.62376800683 0.9968290602914677 0.9064203530900463 0.9401017897000258 0.8301294825677069 0.8866492387737206 0.8750150761669795 0.9433836296897263 0.8514993351020637 0.845054228757091 1.0 16.546798377996346 -4.020065844570909 1.166336255841222 0.8881201253332004 1.4120543736561737 0.2594276765790954 0.049733946986294145 9.865252697059388 3.097741381304857 0.014247332320864952 9.681948930040654 9.548478079661695e-05 4.020065844570909 0.5239342483229733 TTGTPPDS(ph)SLVTYELHSRPEQDK ddPTM_A459_Selumetinib_30min_R1 1 TTGTPPDSSLVTYELHSRPEQDK 23 1 Q13561;Q13561-3;Q13561-2;H0YI98;F8VW18;F8W1I6 Q13561 DCTN2 Dynactin subunit 2 1 T(0.001)TGT(0.003)PPDS(0.492)S(0.492)LVT(0.011)Y(0.001)ELHSRPEQDK 70.072 0.0014122 13521000.0 1208.3 1716.9 1451.9 1395.8 1512.1 1586.6 1601.5 1580.1 826.38 1263.3 True False 1236.4510390574776 1515.8845498348435 1254.7399547158263 1152.0497324110258 1375.3308219829382 1570.640244517539 1480.6975656249526 1538.1906151118508 1402.3065035928225 1425.4568605840532 0.8674068456556909 1.0634376891726764 0.880237059016799 0.8081968414947303 0.9648351065632552 1.1018504227998873 1.0387529826881368 1.0790860513881895 0.983759342263262 1.0 10.477208663493757 -6.544198252508559 8.506702390012382 1.0444116507137187 0.9109092868785914 0.46688733562837104 0.06843695186068557 0.19382882292237125 65.46560970623281 0.023040935268802132 0.02329184892580836 2.8562863702168174e-07 6.544198252508559 -0.13350236383512726 TTHFVEGGDAGNR ddPTM_A459_Selumetinib_30min_R2 2 TTHFVEGGDAGNR 13 0 A8MUD9;P18124 A8MUD9 RPL7 60S ribosomal protein L7 0 ; 108.68 0.008699600000000002 10703500.0 74059.0 48841.0 75725.0 75609.0 99026.0 68841.0 82653.0 84040.0 78798.0 63834.0 False True 69943.0972616666 52586.94765143267 70852.93594314618 65310.92376719991 86585.46857632766 78323.22287362171 86496.52827381238 84284.54248642901 94559.80180007622 61990.946559349875 1.1282792269465247 0.8483004465996683 1.1429561875670324 1.0535558398785136 1.3967437727931948 1.2634622831357378 1.3953090422808911 1.3596266417021934 1.5253808345956625 1.0 15.919769912667473 -6.251770977981283 21.524284689296945 1.3419982855744677 1.0364663525313111 0.46010216047001673 0.1477761520317599 84.06494241131733 187147.3064036926 0.04152248306460223 0.0527013470177339 5.60052863417605e-07 6.251770977981283 -0.3055319330431565 TTHFVEGGDAGNREDQINR ddPTM_A459_Selumetinib_30min_R1 1 TTHFVEGGDAGNREDQINR 19 1 A8MUD9;P18124 A8MUD9 RPL7 60S ribosomal protein L7 0 71.697 0.011117 81330000.0 979.36 1044.0 1208.7 1363.0 1246.7 876.22 992.71 1331.5 683.93 869.86 False True 1002.1771824971713 921.7679946575678 1044.56517891385 1124.9776366787714 1133.9362051227617 867.4060223441054 917.8290854645934 1296.1842946784568 1160.5792577291797 981.5150041539182 1.0210513117535724 0.939127767539475 1.0642376066520574 1.1461644823743884 1.1552917686675948 0.8837419893461775 0.9351146763729576 1.320595496954006 1.1824365932435417 1.0 9.93886651172292 -7.752125340250627 24.99986956518419 1.1886370523004521 1.0239520219130596 0.26564367233555164 0.11027190695162058 238.49326350070146 640145.4384381097 0.05485380605724925 0.031119250757224607 1.7695981669147772e-08 7.752125340250627 -0.16468503038739257 TTHLAGALS(ph)PGEAWPFESV ddPTM_A459_Selumetinib_30min_R1 4 TTHLAGALSPGEAWPFESV 19 0 Q9Y3X0 Q9Y3X0 CCDC9 Coiled-coil domain-containing protein 9 1 T(0.001)T(0.001)HLAGALS(0.999)PGEAWPFESV;TTHLAGALS(1)PGEAWPFESV;TTHLAGALS(0.987)PGEAWPFES(0.012)V;T(0.004)T(0.004)HLAGALS(0.945)PGEAWPFES(0.048)V 153.94 9.5377e-06 151647000.0 7948.200000000001 9953.099999999999 10484.0 10918.1 9331.8 7700.6 9296.0 8543.5 4422.53 7038.6 True False 8133.377595495029 8787.786424929338 9060.330384489787 9011.45879311994 8487.740337663106 7623.138955585379 8594.795235747464 8316.898626800903 7504.7104011887595 7942.0728717698985 1.024087505467889 1.1064852421797247 1.1408017189938833 1.1346482132078106 1.068705925355178 0.9598424842816325 1.0821853909572736 1.0471949528898585 0.9449309421302663 1.0 12.955299882902803 -6.538973984790853 11.358512020974112 1.0144371420259304 1.1043033699875513 0.47135633031426627 0.04730260532216375 0.4570594536885962 316.4626644130123 0.015849183934740548 0.015974516131409752 2.8908530457310473e-07 6.538973984790853 0.08986622796162091 TTHLAGALS(ph)PGEAWPFESV ddPTM_A459_Selumetinib_30min_R2 2 TTHLAGALSPGEAWPFESV 19 0 Q9Y3X0 Q9Y3X0 CCDC9 Coiled-coil domain-containing protein 9 1 TTHLAGALS(1)PGEAWPFESV;T(0.016)T(0.016)HLAGALS(0.968)PGEAWPFESV 81.52600000000002 0.0056763 177141000.0 176582.0 175783.0 199414.0 220590.0 228540.0 169535.0 178846.0 217790.0 195956.0 202627.0 True False 166768.27935375305 189264.99086856883 186583.9203455468 190545.2614610246 199828.76202647726 192886.90736449865 187162.69337662577 218423.73284292463 235152.6754681053 196776.63202182864 0.8475004254329004 0.9618265589969721 0.9482016153465257 0.9683327715451864 1.0155106324022765 0.9802327917834344 0.9511428844653852 1.1100084933799184 1.1950233777861365 1.0 17.586199379728242 -7.76410395928848 22.100102578883185 1.114387212120856 0.9573979373953594 0.5602107221769558 0.05987040987387381 11.16172754221229 92557.82631106307 0.03027748617606967 0.015632929975304855 1.721456451838003e-08 7.76410395928848 -0.15698927472549662 TTHLAGALS(ph)PGGGQSAPAFPESGPSLR ddPTM_A459_Selumetinib_30min_R1 4 TTHLAGALSPGGGQSAPAFPESGPSLR 27 0 A0A2R8Y4Z8 A0A2R8Y4Z8 1 TTHLAGALS(1)PGGGQSAPAFPESGPSLR;TTHLAGALS(1)PGGGQSAPAFPESGPSLR;TTHLAGALS(1)PGGGQSAPAFPESGPSLR;TTHLAGALS(0.999)PGGGQS(0.001)APAFPESGPSLR 124.2 5.0389e-12 123834000.0 5948.2 6693.5 7424.0 7482.4 7094.299999999999 5729.1 6976.6 6026.030000000001 3292.08 5355.15 True False 6086.78148681759 5909.821908276272 6415.861577112956 6175.739302043457 6452.6218176003895 5671.470455606599 6450.349445107119 5866.200109095925 5586.419315990056 6042.535666078278 1.0073223929794408 0.9780367439869593 1.0617829884117131 1.0220443276343343 1.0678665669818488 0.9385911426961411 1.067490504246129 0.9708176224805308 0.9245157372179401 1.0 12.560938368188303 -7.974648819200167 21.94341503509907 0.9573941384225995 1.0191441599056303 0.26559748867045374 0.04213351841193267 64.09167554841733 55475.829892407724 0.0219579621805808 0.010546723589833482 1.060110609218588e-08 7.974648819200167 0.06175002148303088 TTHLAGALS(ph)PGGGQSAPAFPESGPSLR ddPTM_A459_Selumetinib_30min_R2 2 TTHLAGALSPGGGQSAPAFPESGPSLR 27 0 A0A2R8Y4Z8 A0A2R8Y4Z8 1 TTHLAGALS(1)PGGGQSAPAFPESGPSLR;TTHLAGALS(1)PGGGQSAPAFPESGPSLR 132.13 3.7301e-12 81691000.0 95226.0 85000.0 110369.0 116761.0 122131.0 80345.0 106565.0 92490.0 80126.0 108558.0 True False 89933.72013988109 91519.22668192265 103267.97870068107 100857.95037604027 106787.81191500698 91411.79445070737 111520.4836545414 92759.13058745615 96153.43890749654 105423.64847244283 0.853069699664106 0.8681090818616971 0.9795523129487854 0.9566918982357548 1.0129398238661864 0.867090029374215 1.0578317604298455 0.8798702371954323 0.9120670769863417 1.0 16.685839000871475 -5.212362907113933 6.826439228624071 0.956134380963368 0.8592758081343417 0.32368649498618507 0.05642055639384887 0.27884469115546107 31.580921785301655 0.013801886010858173 0.03680516201827555 6.132493448151603e-06 5.212362907113933 -0.09685857282902632 TTHS(ph)PYEER ddPTM_A459_Selumetinib_30min_R2 1 TTHSPYEER 9 0 Q8NDT2;Q8NDT2-2 Q8NDT2 RBM15B Putative RNA-binding protein 15B 1 T(0.003)T(0.002)HS(0.995)PYEER 117.02 0.0076638 56626000.0 23393.0 22891.0 20629.0 25208.0 24430.0 19283.0 21211.0 22265.0 20311.0 20657.0 True False 22092.91070959864 24646.66609383396 19301.752599156956 21774.626913774504 21360.884993028954 21939.058216354326 22197.35352879913 22329.787463830828 24373.76753675666 20060.578736668387 1.1013097378499548 1.2286119168029157 0.9621732679065542 1.0854436055712111 1.0648189802213313 1.0936403432993833 1.1065161090405118 1.1131178096579335 1.2150081937668262 1.0 14.292075607058743 -7.498747886783504 2.617912822685181 1.1222802266414977 1.0886776685229134 0.006993802765567714 0.07743506407226235 1.2556977345649512 17.163482860290042 0.040668694267618 0.02274375947563594 3.17140796958198e-08 7.498747886783504 -0.03360255811858437 TTIACSLGELPNLKEEDILNKS(ph)LDAK ddPTM_A459_Selumetinib_30min_R1 1 TTIACSLGELPNLKEEDILNKSLDAK 26 2 Q7Z4H7;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 T(0.018)T(0.018)IACS(0.016)LGELPNLKEEDILNKS(0.947)LDAK 42.322 0.0324 10763000.0 1240.3 1058.1 1277.6 1574.3 1170.9 979.68 1092.2 1134.9 804.93 886.14 True False 1269.1965767963181 934.2171601026548 1104.1089373544603 1299.3780582710112 1064.992301739186 969.82530867827 1009.8144746647354 1104.798765325258 1365.9074202388383 999.8847007345464 1.269342931103883 0.9343248870758296 1.1042362549835472 1.2995278928824971 1.065115108728846 0.9699371417182462 1.00993091895785 1.1049261625001747 1.3660649265214282 1.0 9.965617933393325 -11.661309418922471 2.371799497315353 0.7582979207124705 1.1134769696987155 0.06384416183562969 0.137341959584066 12218933.658340579 4215110.364381143 15828311.298838554 0.03493535468733167 2.1811753505220604e-12 11.661309418922471 0.35517904898624497 TTIFS(ph)PEGR ddPTM_A459_Selumetinib_30min_R1 1 TTIFSPEGR 9 0 H0YLS6;H0YLC2;H0YMI6;H0YMA1;H0YMZ1;H0YL69;P25789 H0YLS6 PSMA4 Proteasome subunit alpha type;Proteasome subunit alpha type-4 1 T(0.004)T(0.002)IFS(0.994)PEGR 150.15 0.0013502 13662000.0 3553.2 3896.9 3929.2 4422.3 4485.3 3125.2 4005.4 3707.6 2230.7 3341.8 True False 3635.982646676349 3440.649136380341 3395.636221550675 3650.0283218521863 4079.605406944033 3093.7633254545644 3703.2694532339583 3609.2624040179103 3785.3349761181394 3770.752581888538 0.9642591413025855 0.9124568800685225 0.9005194978478301 0.9679840410065069 1.08190747558961 0.820463092782685 0.9821035384345527 0.9571729583515269 1.0038672370867403 1.0 11.880636775742888 -8.09525457027997 2.003667678899602 1.003083267235348 0.9450016312191347 0.10549933599807049 0.06289578786427015 0.8330481486422002 5.967253009528897 0.0558494519448593 0.01757896495312052 8.030552575108918e-09 8.09525457027997 -0.0580816360162133 TTIPEEEEEEEEAAGVVVEEELFHQQGT(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 TTIPEEEEEEEEAAGVVVEEELFHQQGTPR 30 0 P20700 P20700 LMNB1 Lamin-B1 1 TTIPEEEEEEEEAAGVVVEEELFHQQGT(1)PR;TTIPEEEEEEEEAAGVVVEEELFHQQGT(1)PR;TTIPEEEEEEEEAAGVVVEEELFHQQGT(1)PR 141.82 3.0334e-18 54675900.0 5899.1 5959.3 6784.8 6775.2 6668.3 5500.9 5951.2 6455.699999999999 3673.88 5117.9 True False 6036.537552349561 5261.582385596589 5863.461426238683 5592.038506255324 6065.1534423839885 5445.56594041758 5502.296192661391 6284.473864931068 6234.306030421359 5774.8323175675805 1.0453182396285081 0.9111229722792752 1.015347477432632 0.9683464728913114 1.050273515983005 0.9429825215619957 0.9528062271042729 1.0882521810742645 1.0795648579190804 1.0 12.495563340606216 -7.763359491363883 24.999996578216404 1.0629313981879533 0.9825640460043784 0.32672392825511853 0.04715272025964882 52.3224809404183 681204.1470662582 0.02315199100745751 0.011994948871488702 1.724409904453013e-08 7.763359491363883 -0.08036735218357494 TTIPEEEEEEEEAAGVVVEEELFHQQGT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 TTIPEEEEEEEEAAGVVVEEELFHQQGTPR 30 0 P20700 P20700 LMNB1 Lamin-B1 1 TTIPEEEEEEEEAAGVVVEEELFHQQGT(1)PR 111.22 4.7364e-11 1213900.0 6409.5 6787.3 7602.7 7535.6 9297.1 7496.9 5765.3 6308.4 6758.2 6263.9 True False 6053.285649261426 7307.864085390733 7113.550559193877 6509.238280364934 8129.115180871454 8529.529924917633 6033.397873725222 6326.756399588162 8110.028839885225 6083.044931433276 0.9951078312740922 1.201349680589794 1.169406216685267 1.070062502206644 1.3363562611325455 1.4021809835469883 0.9918384529018501 1.0400640585269296 1.3332186316720753 1.0 12.570577945146304 -10.974007453560185 3.233150125522116 0.9971228333327683 1.1714709415234432 0.11718573813911104 0.14085340900512308 30458401.80652117 45320815.48981631 811658.8361431969 0.03597825576608555 1.0616773360511914e-11 10.974007453560185 0.17434810819067492 TTIPEEEEEEEEAAGVVVEEELFHQQGTPR ddPTM_A459_Selumetinib_30min_R1 2 TTIPEEEEEEEEAAGVVVEEELFHQQGTPR 30 0 P20700 P20700 LMNB1 Lamin-B1 0 ; 188.96 1.8394e-39 3050600.0 342.105 348.54999999999995 349.03999999999996 405.68 644.89 547.25 555.18 405.39 412.93 527.03 False True 350.0753808795486 307.74160396350106 301.64228513948086 334.835603556745 586.5598133645768 541.7451618632441 513.3023256220179 394.63774030769764 700.7120507860601 594.6794342069293 0.5886791450025723 0.5174915866628355 0.5072351048119802 0.5630522669802518 0.9863462222244479 0.9109868791506488 0.8631580244683645 0.6636142392144276 1.1783021414226929 1.0 9.215968373643019 -6.250371857217379 21.03460605081909 0.9122490660624362 0.5395782902190682 0.7030185288159181 0.1235724434242875 49.76075618820117 94572.30437558192 0.03585756192680859 0.04565072994266245 5.618600361320318e-07 6.250371857217379 -0.37267077584336794 TTKPPYPGS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 TTKPPYPGSPVK 12 1 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 T(0.015)T(0.003)KPPYPGS(0.983)PVK;TTKPPY(0.006)PGS(0.994)PVK 112.12 0.030906 37383000.0 9346.0 11891.9 9057.3 9916.1 8572.5 8838.3 9763.3 8561.7 5293.3 10071.0 True False 9563.743615849697 10499.59081960568 7827.36840818766 8184.439283250441 7797.118888597804 8749.39472653433 9026.846420522075 8334.615903678965 8982.343492664262 11363.71094984723 0.8416039142546361 0.9239579276474675 0.6888038988965034 0.7202259296608094 0.6861419586444714 0.7699416823561457 0.7943572711732367 0.7334413855177312 0.7904410392262765 1.0 13.472146419909576 -8.57523542311899 18.60707526154198 1.0000000011404817 0.7682103928660309 0.5011663443476349 0.06847084926464511 1028.1763279440345 365405.227714021 0.0715228354784119 0.018467116713998557 2.6592831201239027e-09 8.57523542311899 -0.23178960827445083 TTKPPYPGS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 TTKPPYPGSPVK 12 1 Q96T17-5;Q96T17;Q96T17-2;Q96T17-4 Q96T17-5 MAP7D2 MAP7 domain-containing protein 2 1 TTKPPYPGS(1)PVK;T(0.005)TKPPYPGS(0.994)PVK 90.453 0.013412 154916000.0 415599.0 351026.0 396890.0 417520.0 420863.0 308844.0 377172.0 393138.0 283827.0 342022.0 True False 392501.67135461426 377948.5654735124 371354.52950115805 360653.0557378266 367990.42737704277 351384.4575933065 394711.2453521398 394281.9664925001 340600.33078898315 332146.9361801231 1.1817109495833518 1.1378956850246273 1.118042917306251 1.0858238220877179 1.1079145621788355 1.0579187080104537 1.1883633487381864 1.187070912129929 1.0254507679826248 1.0 18.341462081076443 -14.522878691087515 0.2490950826681702 0.25378884014855724 1.1332254641344577 0.36480197513780943 0.050786855119572205 216.40641073445428 2.142918241231862 82.0210812870287 0.07639447269936994 3.0000003743507814e-15 14.522878691087515 0.8794366239859004 TTKS(ph)PSDSGYSYETIGK ddPTM_A459_Selumetinib_30min_R1 1 TTKSPSDSGYSYETIGK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.025)T(0.031)KS(0.826)PS(0.115)DS(0.002)GYSYETIGK 115.42 0.00091387 921620000.0 5641.1 6372.7 7441.8 7867.3 6984.7 6015.3 5509.0 5656.7 3191.1 4756.7 True False 5772.5266543301705 5626.581321412144 6431.244434881358 6493.42374251129 6352.93511824894 5954.791543455409 5093.451694678655 5506.665940448839 5415.063631277447 5367.268779181638 1.0755054184579746 1.048313686699708 1.1982340925102595 1.209818999133738 1.183643931321358 1.1094640101782554 0.948983906756253 1.0259717124299588 1.0089048739800761 1.0 12.389972421083685 -7.1128487254457475 5.024328435404111 0.9989896120274562 1.1447962768559636 0.650812049467705 0.05117448603005063 0.16297116376865717 6.121600561856666 0.02235309302799302 0.01726405026832428 7.711720388856581e-08 7.1128487254457475 0.14580666482850746 TTKS(ph)PSDSGYSYETIGK ddPTM_A459_Selumetinib_30min_R2 4 TTKSPSDSGYSYETIGK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.114)T(0.114)KS(0.59)PS(0.179)DS(0.003)GYSYETIGK;T(0.002)TKS(0.82)PS(0.178)DSGYSYETIGK;T(0.001)TKS(0.931)PS(0.045)DS(0.014)GYS(0.01)YETIGK;T(0.122)T(0.122)KS(0.718)PS(0.036)DS(0.002)GYSYETIGK 195.45 4.4471e-07 1295640000.0 555748.0 518789.0 610730.0 589570.0 606540.0 430467.0 456535.0 446664.0 365864.0 582090.0 True False 524861.7509955133 558578.4481304456 571436.2967125479 509269.5489350212 530341.0226636012 489759.9218596374 477764.7821069408 447963.71829079435 439047.023094281 565283.5492485515 0.9284928805963447 0.9881385171618399 1.0108843561291947 0.9009099055014225 0.9381858420762458 0.8663969126833606 0.8451772260877713 0.7924584376925281 0.7766845924986132 1.0 19.108615187062775 -6.633509730951645 1.3218213593986514 0.8355600608687441 0.9693210120024739 0.3651876019494502 0.06324876942288675 0.3935273216640115 1.438191914914384 0.02769523351009343 0.02805252492092619 2.3253603824645426e-07 6.633509730951645 0.13376095113372977 TTKSPS(ph)DSGYSYETIGK ddPTM_A459_Selumetinib_30min_R2 1 TTKSPSDSGYSYETIGK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.022)T(0.005)KS(0.23)PS(0.742)DS(0.001)GYSYETIGK 144.08 0.0023483 92216000.0 141930.0 156930.0 148780.0 165200.0 157410.0 99054.0 121060.0 118690.0 98385.0 163420.0 True False 134042.09879080657 168966.02639051885 139207.6567794156 142699.47501410492 137634.74853674546 112697.78937731497 126689.52987583911 119035.36824981272 118064.74910658268 158701.63998384838 0.8446169731103503 1.064677254801621 0.8771658364310745 0.8991682444404981 0.8672547337932552 0.7101236596470245 0.79828746501128 0.7500575813956766 0.7439415819433154 1.0 17.275957511143872 -6.301102701040115 1.8452529996816218 0.7856897003180888 0.9389820953031025 0.2577348725706404 0.09248679405980727 0.38659114576926323 2.593732836326866 0.031018598660012792 0.03967495392137629 4.999163018485293e-07 6.301102701040115 0.15329239498501368 TTKT(ph)PEDGDYSYEIIEK ddPTM_A459_Selumetinib_30min_R1 1 TTKTPEDGDYSYEIIEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.176)T(0.041)KT(0.781)PEDGDYS(0.002)YEIIEK 107.06 0.0034404 76597000.0 11657.0 13475.0 15924.0 16283.0 12336.0 13518.0 12168.0 11036.0 7324.0 11408.0 True False 11928.585419426488 11897.34073564246 13761.608264270828 13439.479719765533 11220.210978097699 13382.021193361963 11250.157963487003 10743.28943001987 12428.293076204449 12872.327923330076 0.9266843954314488 0.9242571201188459 1.0690846555679336 1.0440597691275049 0.8716536002599774 1.0395960445591281 0.8739800625415223 0.8346034605402265 0.9655046973810503 1.0 13.651985363934758 -7.276399547337408 24.89421876844165 0.9047390107477381 0.9788664527315829 0.1347229876412981 0.07204828628045701 1344.3801563156028 2237084.1458672546 0.03030527194753737 0.02052709411761163 5.291763819774995e-08 7.276399547337408 0.0741274419838448 TTKT(ph)PEDGDYSYEIIEK ddPTM_A459_Selumetinib_30min_R2 2 TTKTPEDGDYSYEIIEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.217)T(0.062)KT(0.721)PEDGDYSYEIIEK;T(0.181)T(0.051)KT(0.768)PEDGDYSYEIIEK 79.029 0.025106 229670000.0 341830.0 353010.0 351160.0 347860.0 345040.0 257540.0 309850.0 293240.0 212845.0 350790.0 True False 322832.4570539095 380084.73189394583 328566.747914099 300480.8679080295 301692.9905032625 293013.79728464904 324258.6389561275 294093.27985150483 255419.94738619347 340661.78123812244 0.9476626813861745 1.1157246067126818 0.9644954791228283 0.8820504220225207 0.8856085628589466 0.860131113680265 0.9518491853639163 0.863299894642228 0.7497757642723504 1.0 18.37798057534605 -5.5887601902047574 3.731654050915447 0.8810200983923515 1.0342587577810136 0.40482778391854746 0.07188530266741414 0.19627442825639962 5.476666357384381 0.01925217672191585 0.036460680006294335 2.577744149195481e-06 5.5887601902047574 0.1532386593886621 TTNESLLT(ph)SFPK ddPTM_A459_Selumetinib_30min_R2 1 TTNESLLTSFPK 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 TTNESLLT(0.923)S(0.077)FPK 200.76 0.00021017 6362600.0 68656.0 56778.0 60374.0 62674.0 61519.0 49712.0 54585.0 58504.0 48373.0 47573.0 True False 64840.37437174386 61132.69002995524 56489.602570241 54137.693081319536 53790.433233162046 56559.37675939461 57123.31065812556 58674.236954141394 58048.951654548226 46199.44388050178 1.4034882008419454 1.3232343269776015 1.2227333886605964 1.171825644078111 1.1643091066700915 1.224243670674685 1.2364501790514872 1.2700204163908677 1.2564859396294046 1.0 15.495587865050716 -14.522878743396856 0.18851830803334657 2.557843759390397e-11 1.2909099990975574 0.5784485887679236 0.06549167020645572 118.22207275816989 1.150549267313795 44.808381469233055 0.20620736465424847 3.0000000130106327e-15 14.522878743396856 1.290909999071979 TTNESLLTS(ph)FPK ddPTM_A459_Selumetinib_30min_R2 1 TTNESLLTSFPK 12 0 Q8TDY2-2;Q8TDY2 Q8TDY2-2 RB1CC1 RB1-inducible coiled-coil protein 1 1 TTNESLLT(0.023)S(0.977)FPK 150.26 0.00055394 6049200.0 33077.0 26709.0 35283.0 32375.0 32274.0 27664.0 30822.0 30407.0 18847.0 27726.0 True False 31238.71275772215 28757.494417029025 33012.9301932258 27965.46915000992 28219.45158677924 31474.464891211228 32255.28407263435 30495.47933585015 22616.92662917889 26925.478339200665 1.1601915614714213 1.0680402425817312 1.2260851888065605 1.038624784960464 1.0480575769639973 1.1689472883156813 1.1979465570226862 1.1325882107524878 0.8399823521891169 1.0 14.716684354456824 -8.247942380567983 24.66527868130075 0.9199911837120358 1.1289715396610356 0.595270118909623 0.06928167385868174 382.5080592391236 699023.5406984729 0.0470943220145005 0.017568393481279677 5.6501193203239006e-09 8.247942380567983 0.20898035594899977 TTNSS(ph)LEEIMDK ddPTM_A459_Selumetinib_30min_R1 1 TTNSSLEEIMDK 12 0 Q709C8-4;Q709C8-2;Q709C8-3;Q709C8 Q709C8-4 VPS13C Vacuolar protein sorting-associated protein 13C 1 TTNS(0.03)S(0.97)LEEIMDK 94.717 0.020766 0.0 1024.5 924.63 676.93 1256.1 977.87 878.31 818.88 843.43 528.65 745.13 True False 1048.3688566700205 816.3738897511746 585.0066241103276 1036.7457149172437 889.4218311569706 869.474998841674 757.1112223159297 821.0594965532486 897.0804389316609 840.7746936808328 1.24690819615462 0.9709781893852755 0.6957947575101523 1.2330838721827702 1.0578598973562885 1.034135548294388 0.9004924006470363 0.9765511530309351 1.0669688867588614 1.0 9.715575436321958 -10.110651474422037 8.039956837758513 0.9999999914414869 1.0122710153638403 0.0 0.14999795731215165 0.0 0.0 0.1451740400083183 0.03520987627013307 7.750835604371834e-11 10.110651474422037 0.012271023922353463 TTNSS(ph)LEEIMDK ddPTM_A459_Selumetinib_30min_R2 1 TTNSSLEEIMDK 12 0 Q709C8-4;Q709C8-2;Q709C8-3;Q709C8 Q709C8-4 VPS13C Vacuolar protein sorting-associated protein 13C 1 T(0.009)T(0.009)NS(0.376)S(0.606)LEEIMDK 90.149 0.024805 3989300.0 24461.0 20502.0 23322.0 21782.0 22654.0 18621.0 20952.0 19085.0 19456.0 20080.0 True False 23101.555545141382 22074.437475679715 21821.48791107366 18815.254023954156 19808.001990670404 21185.87372539201 21926.309515600387 19140.534190308168 23347.743646060622 19500.23822589443 1.1846806832577434 1.1320086052265248 1.1190369911531046 0.9648730341647477 1.0157825643569467 1.0864417900935806 1.1244123923821796 0.9815538645518386 1.1973055598396267 1.0 14.251204128407267 -5.535729652799953 24.945272196982454 1.0539695364295791 1.1501392047217156 0.2916544569217032 0.06755506135382669 269.62982507729976 523384.60538238724 0.01799521218084738 0.031193336789561696 2.9125295960730217e-06 5.535729652799953 0.09616966829213647 TTPATGEQS(ph)PGAR ddPTM_A459_Selumetinib_30min_R1 2 TTPATGEQSPGAR 13 0 O00308-4;O00308-2;O00308 O00308-4 WWP2 NEDD4-like E3 ubiquitin-protein ligase WWP2 1 TTPAT(0.001)GEQS(0.999)PGAR;TTPATGEQS(1)PGAR 176.43 0.0001012 88796000.0 7595.0 8439.2 9996.6 9854.599999999999 8684.0 7610.8 7942.200000000001 7971.3 4624.7 5858.4 True False 7771.948722702597 7451.134540722359 8639.116627393227 8133.679103752463 7898.533733284726 7534.242262053502 7343.113459698097 7759.875229568442 7847.778125276177 6610.382705648393 1.175718421879217 1.12718655976689 1.3069011299468842 1.2304399708662033 1.1948678442680243 1.139758860801765 1.110845436138456 1.1738919779845483 1.1871896794372379 1.0 12.690518083105816 -6.7267703286078095 3.6342813021387914 1.1315069651450156 1.2111310212397173 0.3045001290144964 0.0636335486184648 0.3372101323673417 9.320449429405405 0.02278165773144218 0.021739999535195946 1.8759863385061328e-07 6.7267703286078095 0.07962405609470169 TTPATGEQS(ph)PGAR ddPTM_A459_Selumetinib_30min_R2 4 TTPATGEQSPGAR 13 0 O00308-4;O00308-2;O00308 O00308-4 WWP2 NEDD4-like E3 ubiquitin-protein ligase WWP2 1 TTPATGEQS(1)PGAR;TTPATGEQS(1)PGAR;TTPAT(0.059)GEQS(0.941)PGAR;TTPATGEQS(1)PGAR 146.84 0.00058932 230653000.0 107072.0 87238.7 107292.0 110066.0 107416.0 78004.0 76712.0 84968.0 77790.3 87046.0 True False 101121.36688317647 93929.62777336738 100388.9495306969 95074.82092555964 93921.44176877604 88748.34295018938 80279.26000194426 85215.24281279038 93350.53364258597 84532.75580733121 1.196238853417418 1.1111624940686153 1.1875745510947904 1.1247098242278546 1.111065655813277 1.0498692737814728 0.9496822768314616 1.0080736396079966 1.1043119646466089 1.0 16.3672228627646 -6.662187392933151 2.026308313823586 1.0146987043349562 1.1543224069497775 0.689035895598859 0.04279393425296022 0.19005872599888293 1.6002055983390169 0.01671997577476312 0.016440235766058565 2.1767703190351734e-07 6.662187392933151 0.13962370261482127 TTPDQELVPAS(ph)EPVWERPWSVEEIRR ddPTM_A459_Selumetinib_30min_R1 1 TTPDQELVPASEPVWERPWSVEEIRR 26 2 A0A0A0MR88;A0A096LPC5;Q9Y4E1-6;Q9Y4E1;J3KP36;Q9Y4E1-3;Q9Y4E1-2;Q9Y4E1-1;Q9Y4E1-5;A0A0A0MT65 A0A0A0MR88 FAM21C WASH complex subunit FAM21C 1 T(0.016)T(0.008)PDQELVPAS(0.964)EPVWERPWS(0.011)VEEIRR 56.335 0.011196 17095000.0 332.6 340.94 404.03 322.71 375.93 182.71 304.47 298.3 210.81 285.48 True False 340.3489328730592 301.02258630129415 349.1649451779293 266.3547565169525 341.9271978758321 180.87210328740673 281.50358276979665 290.38811498504214 357.72917304678566 322.1241388106827 1.0565769275462076 0.9344924829685295 1.0839452965775374 0.8268699064291274 1.0614764827568168 0.5614981353313234 0.8738978202910792 0.901478902069204 1.1105320277069597 1.0 8.331472964862435 -5.762268843275757 24.999561848231814 0.8919004663892319 1.0159536578516553 0.11786429450417069 0.14661544316639422 47.10346146290506 1419753.0604893581 0.0409787964662842 0.06505007994004147 1.7287458745446911e-06 5.762268843275757 0.12405319146242333 TTPES(ph)PPYSSGSYDSIK ddPTM_A459_Selumetinib_30min_R1 2 TTPESPPYSSGSYDSIK 17 0 A0A087WTU5;A0A087X0N3;Q96MY1-2;Q96MY1 A0A087WTU5 NOL4L Nucleolar protein 4-like 1 T(0.189)T(0.117)PES(0.694)PPYSSGSYDSIK;T(0.004)TPES(0.996)PPYSSGSYDSIK 328.34 1.2881999999999992e-135 128998000.0 10660.3 12269.7 11595.099999999999 11698.8 11592.0 10785.2 12993.7 11381.1 5792.1 9782.2 True False 10908.664248667084 10833.157819971226 10020.549107325218 9655.82419367396 10543.505646733827 10676.710680178096 12013.57474771211 11079.236256977083 9828.770661753657 11037.840656697002 0.9882969493719278 0.9814562609579267 0.9078359997202385 0.8747928597624274 0.9552145183701989 0.9672825521086139 1.0883990013411815 1.0037503350127603 0.8904613653568404 1.0 13.430170343461098 -6.870236622088449 3.689945728139733 0.999190877526976 0.9378912053573919 0.17226105070553654 0.054454398656641104 0.4001167768277602 10.403964871735393 0.02134019181210589 0.01879077424885848 1.3482281104767262e-07 6.870236622088449 -0.061299672169584096 TTPES(ph)PPYSSGSYDSIK ddPTM_A459_Selumetinib_30min_R2 1 TTPESPPYSSGSYDSIK 17 0 A0A087WTU5;A0A087X0N3;Q96MY1-2;Q96MY1 A0A087WTU5 NOL4L Nucleolar protein 4-like 1 T(0.016)T(0.016)PES(0.969)PPYSSGSYDSIK 194.32 8.9552e-08 69412000.0 31282.0 27809.0 28530.0 29862.0 31163.0 20803.0 22163.0 25204.0 19493.0 27224.0 True False 29543.471671767813 29941.860879971555 26694.410861115306 25794.74408517671 27248.025339245258 23668.424419168132 23193.623415151345 25277.339467253176 23392.144679927005 26437.97238355331 1.1174635952848786 1.1325324213818289 1.0096996272574035 0.9756702863198108 1.0306397534553697 0.895243556343675 0.8772845011964597 0.9560997757520108 0.8847934456001977 1.0 14.690323915534142 -5.46131354778332 0.7806218425804827 0.922366786373305 1.1740141871926966 0.7062679853484412 0.0462318147309156 0.6447106333291561 0.5595700035753469 0.020433181183446125 0.12044637539699761 3.4568970995447066e-06 5.46131354778332 0.2516474008193915 TTPIEAASSGT(ph)RGLKAKFESMAEEK ddPTM_A459_Selumetinib_30min_R1 1 TTPIEAASSGTRGLKAKFESMAEEK 25 3 E7EVW7;P14317 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 1 T(0.007)T(0.007)PIEAAS(0.021)S(0.195)GT(0.762)RGLKAKFES(0.008)MAEEK 40.137 0.037099 16406000.0 5688.9 6824.0 5270.4 5259.0 5153.1 5313.1 5927.2 5526.3 3153.3 5318.5 True False 5821.440301327556 6025.04290760847 4554.708628234931 4340.614373656388 4687.0030148537 5259.6550379088185 5480.106531983902 5379.724572047734 5350.919792080216 6001.181281577046 0.9700490667060375 1.0039761548454929 0.7589686787528609 0.7232933267624472 0.7810134030182146 0.8764366199127112 0.9131713032577793 0.8964442698244902 0.8916444181592947 1.0 12.551030795605007 -8.63623763293972 0.766885361966096 0.9971155452881388 0.8514467215565678 0.1956034979479242 0.08431610894448051 1.5291265203323945 1.9568585935084273 0.094425234615477 0.034809061661147125 2.3108000435822807e-09 8.63623763293972 -0.14566882373157108 TTPPEAAQNGQS(ph)PMAALILVADNAGGSHASK ddPTM_A459_Selumetinib_30min_R2 1 TTPPEAAQNGQSPMAALILVADNAGGSHASK 31 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 1 T(0.003)T(0.003)PPEAAQNGQS(0.995)PMAALILVADNAGGSHASK 74.973 0.00058933 0.0 1263.1 2663.6 2994.6 2937.1 3694.3 2424.8 2338.7 2511.7 2462.0 3072.5 True False 1192.9019585899216 2867.889555176102 2801.930696273953 2537.061913219894 3230.189006538965 2758.7941898571785 2447.4541840461334 2519.00863116568 2954.468794027615 2983.788941686287 0.399794349367001 0.9611569756523447 0.939051236878183 0.8502819612254727 1.0825795891291912 0.9245942805519103 0.8202504372386861 0.8442315057787108 0.9901735182240798 1.0 11.542929774829156 -4.7592582543031146 24.982714218980416 0.9280608857468542 0.3997936641134204 0.8137785328874165 0.07670557605923047 24.28540502701538 278099.8587629451 0.01951921816624076 0.12561382275630045 1.7407714114654652e-05 4.7592582543031146 -0.5282672216334339 TTPPESAPQNGPSPMAALMSVADT(ph)LGTAHSPK ddPTM_A459_Selumetinib_30min_R1 1 TTPPESAPQNGPSPMAALMSVADTLGTAHSPK 32 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 TTPPESAPQNGPS(0.001)PMAALMS(0.168)VADT(0.502)LGT(0.082)AHS(0.246)PK 83.162 3.4042e-06 9396700.0 674.39 1032.0 877.96 949.4 937.23 939.84 1155.0 926.91 504.38 863.76 True False 690.1019748654908 911.172960236216 758.7378542890749 783.6051124452126 852.4577119813962 930.3860629064433 1067.8774201041651 902.325335771993 855.8960215423263 974.6320097348855 0.7080641390520396 0.9348892208907326 0.7784864920406862 0.8040010020380564 0.874645715990056 0.9546024074866186 1.095672427580789 0.9258113080212079 0.878173518818803 1.0 9.928713795362027 -6.630875514768151 2.85422993278263 0.975196842905494 0.8148474446090672 0.5254756479482191 0.07383448761825667 0.2272079731691486 3.737983749326629 0.026525678641593692 0.026522275987443146 2.3395077340016515e-07 6.630875514768151 -0.1603493982964268 TTPPESAPQNGPSPMAALMSVADTLGTAHS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TTPPESAPQNGPSPMAALMSVADTLGTAHSPK 32 0 Q9H1B7 Q9H1B7 IRF2BPL Interferon regulatory factor 2-binding protein-like 1 TTPPESAPQNGPSPMAALMSVADTLGT(0.01)AHS(0.99)PK 169.04 1.0661e-28 6044600.0 1037.2 1052.8 1184.0 1225.1 884.65 1039.3 983.47 992.8 446.05 932.92 True False 1061.3647419601227 929.5376865665588 1023.219303246462 1011.1592829751737 804.6335636976432 1028.8455856088979 909.28606610376 966.4677189311099 756.9142717969681 1052.6693694103342 1.0082603073695013 0.8830291006636308 0.9720234415290634 0.9605668335743323 0.7643744437518579 0.9773682178908829 0.8637907518987732 0.9181113719234452 0.7190427438968449 1.0 10.039836659283996 TTPPPGAQCEVPAS(ph)PQRPSRPGALPEQTRPLR ddPTM_A459_Selumetinib_30min_R1 1 TTPPPGAQCEVPASPQRPSRPGALPEQTRPLR 32 3 D6R9H8;Q9H074 D6R9H8 PAIP1 Polyadenylate-binding protein-interacting protein 1 1 TTPPPGAQCEVPAS(0.947)PQRPS(0.05)RPGALPEQT(0.003)RPLR 48.788 0.009884100000000002 71471000.0 454.06 613.26 466.72 885.93 561.02 386.86 498.3 459.23 283.9 595.55 True False 464.6387145530404 541.4592341031605 403.3419875094503 731.2189564657544 510.2758400561257 382.96853964077593 460.7128298163682 447.04972861073065 481.757564764397 671.9946436482485 0.6914321698020152 0.805749330327377 0.6002160751158861 1.0881321203633083 0.7593451002612849 0.5698982027023991 0.685590032853782 0.6652578749492774 0.7169068523358202 1.0 9.392305923354792 -10.595790266847642 4.429411092393384 1.000019713283344 0.7329932945387031 0.25957114165771444 0.13607442816340157 40383218.01236937 32200828.231103607 7170.219498790551 0.03379786500844951 2.5363532118563798e-11 10.595790266847642 -0.26702641874464084 TTPPPGAQCEVPAS(ph)PQRPSRPGALPEQTRPLR ddPTM_A459_Selumetinib_30min_R2 1 TTPPPGAQCEVPASPQRPSRPGALPEQTRPLR 32 3 D6R9H8;Q9H074 D6R9H8 PAIP1 Polyadenylate-binding protein-interacting protein 1 1 TTPPPGAQCEVPAS(0.895)PQRPS(0.099)RPGALPEQT(0.005)RPLR 49.959 0.0079519 11258000.0 7029.8 4234.0 4063.9 8227.6 5028.1 4054.5 5040.1 5121.2 3961.2 4583.0 True False 6639.11185851907 4558.73418554423 3802.4330984397643 7106.986686598345 4396.425126215674 4612.9705719135345 5274.474636768683 5136.101844139698 4753.5506851755445 4450.676881935965 1.491708347884193 1.0242788471225217 0.8543493943298291 1.59683276839161 0.9878104483521409 1.036464945508912 1.1850949364974752 1.1540046560076465 1.06805117766892 1.0 12.119809049943445 TTPPPGAQCEVPASPQRPS(ph)RPGALPEQTRPLR ddPTM_A459_Selumetinib_30min_R2 1 TTPPPGAQCEVPASPQRPSRPGALPEQTRPLR 32 3 D6R9H8;Q9H074 D6R9H8 PAIP1 Polyadenylate-binding protein-interacting protein 1 1 TTPPPGAQCEVPAS(0.204)PQRPS(0.628)RPGALPEQT(0.168)RPLR 50.865 0.005606399999999999 44861000.0 9671.8 10506.0 14690.0 12234.0 14459.0 10121.0 10516.0 10873.0 7802.3 11023.0 True False 9134.280075283039 11311.776417885616 13744.86139326267 10567.708095172851 12642.531154899947 11515.075880709543 11005.014837058687 10904.638629877954 9362.978014476712 10704.737348806493 0.8532932455649134 1.0567075164293316 1.2839980043784196 0.9871991951629789 1.1810220786322707 1.07569905785623 1.0280508973240405 1.0186740948944206 0.8746574259031794 1.0 13.385961777774229 -7.814575673376625 1.9670270563143855 0.9414499772792742 1.0808199854773746 0.16926261100844098 0.1108799051824085 0.5778352793880499 4.310929671923737 0.08309436619331592 0.03243291300522947 1.5325841389093045e-08 7.814575673376625 0.13937000819810041 TTPPPGAQCEVPASPQRPSRPGALPEQT(ph)R ddPTM_A459_Selumetinib_30min_R2 2 TTPPPGAQCEVPASPQRPSRPGALPEQTR 29 2 D6R9H8;Q9H074 D6R9H8 PAIP1 Polyadenylate-binding protein-interacting protein 1 1 TTPPPGAQCEVPAS(0.4)PQRPS(0.1)RPGALPEQT(0.5)R;TTPPPGAQCEVPAS(0.01)PQRPS(0.076)RPGALPEQT(0.914)R 61.807 0.0030448 30631000.0 13704.9 12727.3 14972.7 13719.6 13487.4 12873.9 9393.0 12348.5 6317.4 13027.3 True False 12943.236523061529 13703.442985280373 14009.37278304316 11850.966812369912 11792.99223311415 14647.16286737146 9829.793111876403 12384.432090595772 7581.056522904162 12651.168000009699 1.0230862891909749 1.0831761134837405 1.107358054452555 0.9367488292275328 0.9321662816512364 1.1577715881537762 0.7769870032449863 0.9789161040772107 0.5992376769400541 1.0 13.626982965262211 -7.272722486154819 24.994626255375994 0.8370281986974728 1.0354713994806155 0.39320834827166873 0.12239833948324869 781.4008387301833 1730971.9897694746 0.04870062475098528 0.03316868750476585 5.3367580499096684e-08 7.272722486154819 0.1984432007831427 TTPPTQKPPS(ph)PPMSGK ddPTM_A459_Selumetinib_30min_R1 2 TTPPTQKPPSPPMSGK 16 1 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;E9PEZ7;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 TTPPTQKPPS(1)PPMSGK;T(0.003)T(0.001)PPT(0.008)QKPPS(0.987)PPMSGK 110.64 0.0015181 185896000.0 16162.9 17838.9 20615.3 22475.6 15602.8 17470.7 15868.7 15477.2 10713.2 15272.400000000001 True False 16539.464122471338 15750.313294920394 17815.855491737155 18550.6583792644 14191.529494898085 17294.960620126407 14671.711183036341 15066.694378969149 18179.517938830362 17232.761305773693 0.9597686539608674 0.9139750162757365 1.0338363757042293 1.0764762564806813 0.8235203426245642 1.00360936435253 0.8513848084300167 0.874305290465619 1.0549393458342318 1.0 14.07286627106945 -6.250133719048945 24.97500707669136 0.9276288418793958 0.9928557237501867 0.121973917032695 0.07918488361253521 1565.9983448524615 3459400.398063797 0.023367280776416 0.029893485183140268 5.621682072366526e-07 6.250133719048945 0.06522688187079095 TTPPTQKPPS(ph)PPMSGK ddPTM_A459_Selumetinib_30min_R2 2 TTPPTQKPPSPPMSGK 16 1 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9;E9PEZ7;H7C3Q7 H0Y6B5;H7C3Q7 ABI2 Abl interactor 2 1 TTPPTQKPPS(0.996)PPMS(0.004)GK;TTPPTQKPPS(0.998)PPMS(0.002)GK 122.29 0.0040922 134651900.0 273566.0 231738.0 214815.0 247359.0 206073.0 159958.0 207755.0 217110.0 134012.0 211944.0 True False 258362.296891466 249511.55944488602 200994.03677288815 213668.2774819247 180184.26742400552 181990.76254584888 217416.01915872275 217741.7541555046 160818.14460813487 205824.62602335517 1.2552545430698332 1.2122531898421798 0.9765305573788877 1.0381084207954763 0.8754261863862675 0.8842030521906459 1.0563168429323528 1.057899428082999 0.7813357794702692 1.0 17.651056079196927 -5.231944196181649 2.4634547330436907 0.9568398917704957 1.2617138236086125 0.6291279288521112 0.08473296636551902 0.20027845453164742 2.2925235507915134 0.023401805435861796 0.08312079228412125 5.8621348402771665e-06 5.231944196181649 0.30487393183811684 TTPS(ph)YVAFTDTER ddPTM_A459_Selumetinib_30min_R1 2 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 1 T(0.012)T(0.021)PS(0.962)YVAFT(0.005)DTER;TT(0.001)PS(0.971)YVAFT(0.025)DT(0.002)ER 212.55 4.379e-06 28410800.0 2248.0699999999997 3866.6 3228.23 3708.8 3853.5 3318.2 3612.8 4160.7 1326.87 2321.24 True False 2300.44565701725 3413.8966744664262 2789.85409739808 3061.1277027984056 3504.9516053906823 3284.8219206845424 3340.2835873180347 4050.344720141685 2251.6014792495093 2619.193764792312 0.8783029678599068 1.303415089160893 1.0651575820391053 1.1687289974291524 1.3381795774351983 1.2541347512504526 1.2753098423716283 1.5464089654561528 0.8596544133221276 1.0 11.354907077135845 -4.752860426392669 24.727523814585698 1.2212777321051254 0.8783022219394274 0.21119786911862282 0.18357345456759167 411.74850000313864 1186698.1970513435 0.043317762218408044 0.48955635280986165 1.7666054813235632e-05 4.752860426392669 -0.34297551016569794 TTPS(ph)YVAFTDTER ddPTM_A459_Selumetinib_30min_R2 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 1 T(0.001)T(0.001)PS(0.442)Y(0.323)VAFT(0.219)DT(0.014)ER 75.89 0.046231 7304600.0 29213.0 24762.0 28984.0 32943.0 31113.0 21890.0 19470.0 27904.0 19071.0 30940.0 True False 27589.458408904593 26661.165777620754 27119.200995393152 28456.106570155258 27204.306786250934 24905.148802364576 20375.393579073083 27985.196020244133 22885.73288826183 30046.681808225778 0.9182198082635374 0.8873247950567978 0.9025689148799393 0.9470631982518923 0.9054013671088068 0.8288818366474789 0.6781245832441631 0.9313905674796583 0.7616725545380016 1.0 14.87491805590553 -6.753425453108521 6.067476290003634 0.8252917692587454 0.9125767993606949 0.14689268762577457 0.08334303748597996 0.25225318406273817 34.40007348203808 0.027180057781038148 0.025790798144184703 1.7643085830443228e-07 6.753425453108521 0.08728503010194955 TTPSVVAFT(ph)ADGER ddPTM_A459_Selumetinib_30min_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 1 T(0.001)T(0.005)PS(0.083)VVAFT(0.911)ADGER 116.98 0.006013800000000001 8109600.0 848.8 1421.4 1413.4 1490.5 1460.9 1364.3 1420.8 1585.7 589.11 923.03 True False 868.5753885227073 1254.9818272090674 1221.4680432504654 1230.2121551501891 1328.761852942843 1350.5763806852876 1313.6279121073574 1543.6420849204883 999.6766431079748 1041.5098915735764 0.8339578870541602 1.2049639061161144 1.172785830583901 1.1811814415814235 1.2758033924529213 1.2967484914087133 1.261272622310527 1.4821194665643167 0.959834036331237 1.0 10.024460825871063 -4.342420420687051 1.7669065396084687 1.2307160702711242 9.050385588676462e-10 0.361023000091663 0.14305198927894225 3.833512778731579 4.21692081048876 0.03677350083370191 11.67325269669408 4.545478200759354e-05 4.342420420687051 -1.2307160693660857 TTPSYVAFT(ph)DTER ddPTM_A459_Selumetinib_30min_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 1 TTPSYVAFT(0.997)DT(0.003)ER 194.86 0.00046205 7503000.0 524.14 820.5 700.07 972.27 879.78 709.32 739.03 861.65 321.46 524.03 True False 536.3514422010978 724.4354785598989 605.0043392092491 802.481296268282 800.2040543377747 702.18488481103 683.2843721035333 838.7962429663484 545.4941414905353 591.2943549844543 0.90708026836346 1.225168940736708 1.0231863945752624 1.3571604218839193 1.3533091388278393 1.187538624192499 1.1555739816279786 1.4185764431801502 0.9225424475849712 1.0 9.207732693708316 -4.229313877207158 1.6835329193221364 1.205946856695597 2.2114170196496934e-15 0.19254820309407938 0.15886158267247932 8.465144232579386 6.355954289696412 0.041463112319198886 26.336925850652733 5.897746788530752e-05 4.229313877207158 -1.2059468566955949 TTPSYVAFT(ph)DTER ddPTM_A459_Selumetinib_30min_R2 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 1 TTPSYVAFT(0.985)DT(0.015)ER 154.13 0.00091908 2990500.0 13486.0 14760.0 14829.0 13878.0 11301.0 11288.0 9515.8 13341.0 8255.5 14956.0 True False 12736.502108735396 15892.044539119708 13874.91828459443 11987.792459114675 9881.267347778148 12842.819537738305 9958.303555199978 13379.82010127856 9906.830677942717 14524.181419645272 0.8769170351664791 1.094178327848775 0.9552977812455128 0.8253678546661568 0.6803321345472068 0.8842370641533868 0.6856361310476657 0.9212099267213186 0.682092187621867 1.0 13.826169235427301 -5.742142463308787 3.9846989251717546 0.7987990397274114 0.9930229020570623 0.30672739660567006 0.1128428708997296 0.214990294594148 7.502520599581381 0.029279773744604123 0.05000492164095511 1.8107460091259807e-06 5.742142463308787 0.19422386232965094 TTPSYVAFTDTER ddPTM_A459_Selumetinib_30min_R1 3 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 0 ;; 296.65 8.069499999999997e-61 75436000.0 4424.4 5441.1 5658.4 5637.200000000001 5003.0 4843.6 4914.7 4576.6 3296.5099999999998 4541.8 False True 4527.479911616245 4804.053482501235 4890.02035936637 4652.768843349646 4550.479533351393 4794.8777816369275 4543.980222152332 4455.213701108091 5593.9367024356525 5124.784270878377 0.8834479018646075 0.9374157483662878 0.9541904792273784 0.9078955517774744 0.8879358218470824 0.9356252923433 0.8866676101808874 0.8693465842893865 1.0915457913464255 1.0 12.323275559936848 -8.260106571226595 24.99999927433909 1.0457729017089372 0.90991018131764 0.7354402237796289 0.03307823554488037 57.159782915288744 1072223.1628306073 0.025155146713392185 0.00832542312426112 5.4940603894174074e-09 8.260106571226595 -0.1358627203912972 TTPSYVAFTDTER ddPTM_A459_Selumetinib_30min_R2 2 TTPSYVAFTDTER 13 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PNE6;E9PI65;E9PPY6;E9PN25;P54652;A0A0G2JIW1;P0DMV9;P0DMV8;P0DMV8-2;P17066;P48741;Q53FA3;P34931 P11142;P54652;A0A0G2JIW1;P17066;Q53FA3 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA6;HSPA7;HSPA1L Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7;Heat shock 70 kDa protein 1-like 0 ; 296.65 8.069499999999997e-61 68193000.0 99950.0 107594.0 102824.0 104720.0 104513.0 84935.0 87550.0 95325.0 69759.0 87337.0 False True 94395.17913155154 115846.11383076181 96208.41578630633 90456.95534792403 91383.14258192535 96634.02528683591 91621.24847703386 95602.37996809673 83712.74922931448 84815.35388122227 1.1129491868152213 1.3658625299494225 1.1343278237220966 1.0665162757512325 1.0774363178381687 1.1393458951095674 1.0802436620773022 1.1271824686598715 0.9869999404417753 1.0 16.372037834941857 -3.2849138706350787 0.18573781018949548 0.9866174608690803 1.6347250701523657 0.3945263630669241 0.07714007139672548 29.68706288738106 0.6045179480318019 0.18095108189791836 4.832901384992116 0.000518902937655265 3.2849138706350787 0.6481076092832854 TTPTPSTNSVLSTS(ph)TNR ddPTM_A459_Selumetinib_30min_R1 1 TTPTPSTNSVLSTSTNR 17 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 TTPTPST(0.001)NS(0.001)VLS(0.018)T(0.186)S(0.608)T(0.186)NR 94.639 0.012819999999999998 0.0 655.69 742.46 835.6 818.49 795.07 713.1 625.65 646.53 347.96 690.01 True False 670.9663012493572 655.53243803971 722.1301096222501 675.5560864601664 723.1560588810091 705.9268614429961 578.456716786295 629.3819241745872 590.4627060071139 778.579504766566 0.8617826402334167 0.8419595353158597 0.9274969418039837 0.8676777160512489 0.928814661128058 0.9066856462586277 0.7429642229790369 0.8083720677482883 0.7583845996359058 1.0 9.604700557628671 -7.233657813271795 24.651392246715815 0.8114612079172197 0.8895091095368671 0.13972510350570877 0.07060789736430799 898.9444697473077 797660.5927649054 0.025430107190913754 0.019693114168827557 5.8390499002571485e-08 7.233657813271795 0.07804790161964748 TTPVDLCLLEESVGS(ph)LEGSR ddPTM_A459_Selumetinib_30min_R1 1 TTPVDLCLLEESVGSLEGSR 20 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 TTPVDLCLLEES(0.001)VGS(0.995)LEGS(0.003)R 170.98 1.6735e-09 7186800.0 1679.4 1484.8 1568.4 1820.5 1954.4 1346.4 1386.0 1543.7 746.41 1514.1 True False 1718.5267524564495 1310.9589257352065 1355.41989460452 1502.5838500173902 1777.6248650773464 1332.856438433388 1281.4529041249987 1502.7560613557152 1266.6032543705307 1708.4494835829291 1.0058984880561914 0.7673384190358894 0.7933625826395277 0.8795014804102951 1.0404901532993203 0.7801556038040678 0.7500677757457358 0.8796022801939467 0.7413758888054645 1.0 10.73847187462309 TTQPSINESES(ph)DPFEVVRDDFK ddPTM_A459_Selumetinib_30min_R1 1 TTQPSINESESDPFEVVRDDFK 22 1 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 TTQPS(0.001)INES(0.033)ES(0.966)DPFEVVRDDFK 80.98100000000002 0.00060745 6024700.0 755.7 1006.7 903.75 860.73 869.06 1156.5 771.24 1067.1 498.52 584.24 True False 773.3063396637722 888.8350959978673 781.0257139434043 710.4196634031681 790.4536764450049 1144.8666600179845 713.0647458711134 1038.7970415706957 845.9520295397926 659.2328949795194 1.1730396731610255 1.3482869298041946 1.1847493046712554 1.0776459561005962 1.199050718592497 1.7366649460863939 1.0816583203016081 1.5757663937612947 1.283236980408986 1.0 9.364644422950843 -6.597843313293733 24.999999184233495 1.368061894424179 1.197474334948772 0.08859975106832929 0.21013422172157992 76.93135954777205 25653.195698656586 0.06513631389907591 0.06513631233415398 2.5243913694187675e-07 6.597843313293733 -0.17058755947540694 TTQS(ph)MQDFPVVDSEEEAEEEFQK ddPTM_A459_Selumetinib_30min_R2 1 TTQSMQDFPVVDSEEEAEEEFQK 23 0 Q9UBB9 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 T(0.061)T(0.061)QS(0.792)MQDFPVVDS(0.085)EEEAEEEFQK 81.226 0.00095547 2541600.0 13176.0 10968.0 13381.0 10335.0 14613.0 10309.0 9559.8 10897.0 10503.0 12749.0 True False 12443.730667707081 11809.210332321483 12520.081028131232 8927.355171130572 12777.184298122484 11728.971174215461 10004.349642384335 10928.708465904538 12603.893478339578 12380.903244119923 1.0050745428139094 0.9538246200195487 1.011241327168711 0.7210584716725293 1.032007442929559 0.9473437392207967 0.8080468318929568 0.882706879330062 1.0180108211673133 1.0 13.595828949212901 TTQSMQDFPVVDS(ph)EEEAEEEFQK ddPTM_A459_Selumetinib_30min_R1 1 TTQSMQDFPVVDSEEEAEEEFQK 23 0 Q9UBB9 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 T(0.013)T(0.013)QS(0.029)MQDFPVVDS(0.946)EEEAEEEFQK 66.77 0.0071896999999999985 2578700.0 444.53 397.54 457.57 509.33 547.43 302.3 414.5 388.25 365.18 408.69 True False 454.8866840951925 350.99583198866804 395.434507252098 420.38507680821596 497.9150531566163 299.2591364664391 383.23393128413545 377.9523487862644 619.6837883080751 461.1493424777144 0.9864194572004088 0.7611326736427697 0.8574977145743363 0.9116028975548882 1.0797262563172334 0.6489419129571916 0.8310408277393471 0.8195877429978757 1.3437811381852336 1.0 8.84909023058279 -8.245589040434748 24.727863739778524 1.1718905786296607 0.859259678391574 0.4565369164183841 0.13521961668005977 519.284939921578 810131.8514068099 0.08930989870901321 0.03350208177881036 5.680819096612426e-09 8.245589040434748 -0.3126309002380867 TTQSMQDFPVVDS(ph)EEEAEEEFQK ddPTM_A459_Selumetinib_30min_R2 1 TTQSMQDFPVVDSEEEAEEEFQK 23 0 Q9UBB9 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 TTQSMQDFPVVDS(1)EEEAEEEFQK 110.08 3.101e-05 0.0 7981.3 6714.1 6016.5 8260.3 9073.4 6055.4 6279.6 6184.7 4865.2 6580.8 True False 7537.731297675354 7229.049880765832 5629.404940269903 7135.232890187703 7933.518374774828 6889.47638455178 6571.6138427913365 6202.696453067796 5838.37594504596 6390.795205028197 1.1794668825789882 1.1311659423976075 0.8808614201626673 1.1164859240949845 1.2413976853041442 1.0780311625588044 1.028293605406237 0.9705672383598825 0.9135601686081881 1.0 12.641779741182154 -7.517757862543633 2.3230678856035976 0.9550124470844553 1.1022687719258881 0.3446956934389491 0.08924243299306685 0.39093360117980197 4.195665333088306 0.05384635723244028 0.02879782246405998 3.035583177883673e-08 7.517757862543633 0.1472563248414328 TTRT(ph)PDTSTYCYETAEK ddPTM_A459_Selumetinib_30min_R1 4 TTRTPDTSTYCYETAEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.293)T(0.293)RT(0.413)PDT(0.001)STYCYETAEK;T(0.152)T(0.029)RT(0.819)PDTSTYCYETAEK;T(0.001)TRT(0.999)PDTSTYCYETAEK;T(0.319)T(0.319)RT(0.361)PDTSTYCYETAEK 209.23 4.3303e-08 607011000.0 14968.099999999999 17199.8 26709.4 29466.1 20608.7 18132.5 16195.999999999998 14873.2 9570.2 11283.2 True False 15316.827607147425 15186.039420029905 23082.410184232303 24320.398782201264 18744.646723761496 17950.103512992744 14974.322680525587 14478.714421037648 16239.930420247374 12731.508627675132 1.2030646214112013 1.1927918257086387 1.813014534197219 1.9102527040145714 1.4723036579510538 1.409896033371386 1.1761624736266632 1.1372347806107224 1.2755699968616292 1.0 13.636115761923689 -7.117527125783136 2.3212024840838335 1.151388030772922 1.5371155838507107 0.3873348041429837 0.22081136863941808 0.37379818457964686 3.9491075042554504 0.11066011957848101 0.08070507265428489 7.629092388018475e-08 7.117527125783136 0.3857275530777886 TTRT(ph)PDTSTYCYETAEK ddPTM_A459_Selumetinib_30min_R2 4 TTRTPDTSTYCYETAEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.054)T(0.011)RT(0.921)PDT(0.015)STYCYETAEK;T(0.001)TRT(0.997)PDT(0.001)STYCYETAEK;T(0.174)T(0.04)RT(0.786)PDTSTYCYETAEK;T(0.08)T(0.017)RT(0.903)PDTSTYCYETAEK 197.94 7.727600000000002e-07 138654400.0 242429.0 314962.0 330082.0 317101.0 332926.0 208230.0 167814.0 162972.0 121167.0 358629.0 True False 228955.76670017903 339118.57263754844 308844.88348610833 273911.2967702633 291100.85948379675 236911.79237626193 175617.68351713262 163446.2215385329 145403.7856888481 348274.4489399552 0.6574004133724219 0.9737107435521768 0.8867859368556641 0.7864811719721861 0.835837542403188 0.6802445401818928 0.5042508402544634 0.46930293633660186 0.41749771231112237 1.0 18.409865108315273 -6.940480466365131 2.9655928701230727 0.5547216904043979 0.8382726242055583 0.2809190296931908 0.1684945128351256 0.2726169084748344 4.874251785929907 0.0626669071003367 0.0526589980956606 1.1468841046510535e-07 6.940480466365131 0.28355093380116037 TTRT(ph)PEEGGYSYDISEK ddPTM_A459_Selumetinib_30min_R1 6 TTRTPEEGGYSYDISEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.014)T(0.003)RT(0.983)PEEGGYSYDISEK;TTRT(0.999)PEEGGYSYDISEK;TTRT(1)PEEGGYSYDISEK;T(0.01)T(0.002)RT(0.989)PEEGGYSYDISEK;T(0.002)TRT(0.998)PEEGGYSYDISEK;T(0.038)T(0.007)RT(0.954)PEEGGYSYDISEK 226.08 3.7817e-15 855768300.0 21135.800000000003 23620.7 31973.200000000004 34070.1 26734.6 23425.300000000003 23954.5 22059.3 13842.599999999999 17996.7 True False 21628.22301689236 20855.177463034495 27631.415056216054 28120.396609984884 24316.460150376985 23189.66275047064 22147.59277912142 21474.215705295148 23489.881176497496 20306.75174770286 1.0650754628612125 1.027007062584181 1.3607008840959398 1.3847806364780089 1.1974569075592167 1.1419681019685437 1.0906516736053957 1.0574914182286368 1.1567522698037966 1.0 14.309671865256183 -6.9724737879142555 2.616360319158011 1.081576635330325 1.2152758361404505 0.23769349642394355 0.11001280310886838 0.48269629093660543 6.6873126284771915 0.04994608311922229 0.040697300010792005 1.0654331665401885e-07 6.9724737879142555 0.13369920081012543 TTRT(ph)PEEGGYSYDISEK ddPTM_A459_Selumetinib_30min_R2 1 TTRTPEEGGYSYDISEK 17 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.047)T(0.009)RT(0.944)PEEGGYSYDISEK 191.61 8.245100000000002e-07 138490000.0 71672.0 76249.0 74779.0 71486.0 74579.0 53443.0 46944.0 47315.0 41854.0 67332.0 True False 67688.75716574851 82097.05312082241 69967.80055321904 61749.48347977172 65209.719275280724 60804.288142748745 49126.98901777127 47452.678816580075 50225.969498469436 65387.95021045447 1.0351870176062832 1.2555379524299024 1.0700411976216426 0.9443556998044416 0.9972742541309201 0.9299005083818506 0.7513156301681508 0.7257098389512318 0.7681227097166156 1.0 15.996737177760371 -6.346953432189645 0.8891965966275991 0.7939865976998888 1.14537658245293 0.5986255934006364 0.09875947456230592 0.37860479368584726 0.6479722733381754 0.051526194865854864 0.07603365081264885 4.4982808572936603e-07 6.346953432189645 0.3513899847530413 TTRTS(ph)DVGGYYYEK ddPTM_A459_Selumetinib_30min_R1 1 TTRTSDVGGYYYEK 14 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 TTRT(0.029)S(0.97)DVGGYYYEK 159.18 0.0014251 8054400.0 2479.0 2332.7 4599.5 5585.7 2946.2 2925.8 2420.5 2338.9 1535.5 1751.6 True False 2536.7558767056944 2059.5863995571904 3974.9131632450226 4610.262351574916 2679.716730193856 2896.369108413849 2237.9197362442706 2276.8647741820837 2605.6313515171946 1976.4349220288339 1.283500837002862 1.0420714472313617 2.0111530710885877 2.332615306575552 1.355833526480647 1.4654512911766868 1.1323012517644748 1.1520059420144504 1.318349176325261 1.0 10.948684737056157 -6.939820762397089 2.0811766522059902 1.1665710571866879 1.644841418080426 0.2745457386349227 0.35016184934079714 0.496312229916316 4.360608187790515 0.16606223594458672 0.13514399366016508 1.148627573581388e-07 6.939820762397089 0.4782703608937382 TTRTS(ph)DVGGYYYEK ddPTM_A459_Selumetinib_30min_R2 2 TTRTSDVGGYYYEK 14 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.002)TRT(0.21)S(0.787)DVGGYYYEK;TTRT(0.137)S(0.854)DVGGY(0.008)YYEK 181.81 0.00035732 19405800.0 71952.0 116454.0 94648.0 100719.0 93357.0 62220.0 44945.0 40667.0 24138.2 111557.0 True False 67953.19588667728 125385.64734137197 88558.45072495086 87000.89845003406 81628.65903783073 70790.24022307555 47035.03155682791 40785.33423721573 28966.514477659348 108336.05955010488 0.6272444850668514 1.1573768499802388 0.8174420510835824 0.8030650072683932 0.7534763529042505 0.6534319276245729 0.4341585964281306 0.37647053443320705 0.26737648201301323 1.0 16.725153996933017 -6.791111274146702 1.5424308937080173 0.4683644334848096 0.8740971395378305 0.3005459050585404 0.22051747660517992 0.39297696691300465 1.9415882542699354 0.09489688192339499 0.08404992731468205 1.617665509209361e-07 6.791111274146702 0.4057327060530209 TTS(ph)ATPLKDNTQQFR ddPTM_A459_Selumetinib_30min_R2 1 TTSATPLKDNTQQFR 15 1 Q14207 Q14207 NPAT Protein NPAT 1 T(0.104)T(0.104)S(0.396)AT(0.396)PLKDNTQQFR 65.565 0.036115 15950000.0 16399.0 16163.0 14788.0 18951.0 14146.0 12845.0 17747.0 13664.0 12371.0 15486.0 True False 15487.609230398331 17402.650127763685 13836.55617995701 16369.841107701555 12368.853013155458 14614.282154699542 18572.27066501335 13703.759977803027 14845.545674620478 15038.878942539899 1.0298380144938282 1.1571773530630316 0.9200523677877395 1.088501421565195 0.8224584465646677 0.9717667261328026 1.2349504731019998 0.9112221748816481 0.9871444361871584 1.0 13.876409406384258 -5.257764624324724 24.992765527027178 0.9941852640156092 1.0935076782632 0.12283848870597414 0.10836314901911653 676.9753501976934 4604202.503242093 0.0279247175171759 0.06822459385083478 5.523767311790571e-06 5.257764624324724 0.0993224142475908 TTS(ph)FAESCKPVQQPSAFGSMK ddPTM_A459_Selumetinib_30min_R1 1 TTSFAESCKPVQQPSAFGSMK 21 1 P49841;P49841-2;A0A3B3ITW1 P49841 GSK3B Glycogen synthase kinase-3 beta 1 T(0.128)T(0.038)S(0.669)FAES(0.164)CKPVQQPSAFGSMK 88.709 0.00047448 151880000.0 1632.8 1910.5 1710.5 2228.1 1869.2 2140.5 2076.8 1839.6 1135.4 1634.5 True False 1670.8410631242662 1686.8177718326456 1478.2234951039475 1839.0041616169974 1700.1311900340636 2118.968513418499 1920.1453039587288 1790.807832137056 1926.6908736650105 1844.3039963782442 0.9059466695324544 0.9146094001559057 0.8015075052739743 0.9971263767949025 0.9218280681344831 1.1489258373780178 1.0411219125097697 0.9709938468136265 1.0446709856122167 1.0 10.848860759258136 -6.2144211167627335 1.870349978512656 1.0346465277153778 0.8834892448721745 0.5047312949067155 0.06370743762972242 0.281593558662296 1.9394278499159154 0.02178232565708324 0.029686594629303394 6.103499077061287e-07 6.2144211167627335 -0.1511572828432033 TTS(ph)FAESCKPVQQPSAFGSMK ddPTM_A459_Selumetinib_30min_R2 3 TTSFAESCKPVQQPSAFGSMK 21 1 P49841;P49841-2;A0A3B3ITW1 P49841 GSK3B Glycogen synthase kinase-3 beta 1 T(0.145)T(0.041)S(0.812)FAES(0.002)CKPVQQPSAFGSMK;T(0.125)T(0.029)S(0.845)FAES(0.001)CKPVQQPSAFGSMK;T(0.173)T(0.059)S(0.733)FAES(0.036)CKPVQQPSAFGSMK 104.81 8.3283e-05 143237000.0 386632.0 377196.0 348338.0 411066.0 356797.0 402537.0 335514.0 392751.0 292966.0 384567.0 True False 365144.54125052557 406125.72032369906 325926.3123217387 355078.1016715971 311972.9710543495 457982.817882934 351116.06580837874 393893.84038657194 351567.38615397725 373463.55148493766 0.9777247064637642 1.0874574472097547 0.872712507086207 0.9507704306344281 0.8353505176446431 1.226311954839869 0.9401615349404178 1.0547049071332422 0.9413700072098106 1.0 18.51060792318669 TTS(ph)FFSR ddPTM_A459_Selumetinib_30min_R2 4 TTSFFSR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 1 T(0.005)T(0.337)S(0.658)FFSR;T(0.022)T(0.035)S(0.943)FFSR;T(0.012)T(0.043)S(0.945)FFSR;T(0.05)T(0.196)S(0.755)FFSR 104.01 0.018263 21778900.0 177995.0 168608.0 180641.0 184518.0 152160.0 117147.0 155747.0 148178.0 148004.0 139378.0 True False 168102.75047044022 181539.6914398305 169018.75472704988 159386.33008869612 133044.30047234095 133282.93589541366 162989.5441068256 148609.1734478117 177608.9355772797 135353.79499246555 1.2419507741160685 1.3412235057756294 1.2487182552691505 1.1775534634811557 0.9829373493351025 0.984700398705724 1.2041741726997635 1.097931339539346 1.3121829024976084 1.0 17.046375812230224 -5.839917947856876 3.0586137290065536 1.100653697668438 1.2885674272248024 0.39347558488898604 0.09984835009743025 0.26268235124286016 4.941558668503182 0.03009778555778144 0.049523422793710976 1.445712886432171e-06 5.839917947856876 0.18791372955636443 TTS(ph)FKGTSPSSK ddPTM_A459_Selumetinib_30min_R1 1 TTSFKGTSPSSK 12 1 F5GWA4;Q9H3F6-2;Q9H3F6;F8W8I7;F5H6V0;F5H497 F5GWA4 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 TT(0.001)S(0.996)FKGT(0.003)SPSSK 142.39 0.0043316000000000006 7809400.0 4660.8 4436.9 4405.3 5328.8 3899.9 4220.0 3407.3 3145.6 2296.3 2915.8 True False 4769.387571661917 3917.425685341151 3807.0844565807784 4398.22511396466 3547.15473358327 4177.5506314534305 3150.2846177670335 3062.1684696511875 3896.653384883708 3290.071332297144 1.4496304456511302 1.1906810794299663 1.1571434391735977 1.336817554923284 1.07813915727676 1.2697446983730423 0.9575125581145042 0.930730115055945 1.1843674471832941 1.0 11.683903148147142 -6.848393255735517 1.0746644012002529 1.0159931462049343 1.2707263913960338 0.44822958315104555 0.11847797446600304 0.48191281365067495 1.1759856327459262 0.06665565191244095 0.05533790623371285 1.4177731398944604e-07 6.848393255735517 0.2547332451910995 TTS(ph)GDDACNLTSFRPATLTVTNFFK ddPTM_A459_Selumetinib_30min_R1 2 TTSGDDACNLTSFRPATLTVTNFFK 25 1 Q96N67-2;Q96N67-6;Q96N67;Q96N67-4;Q96N67-3;Q96N67-5;A0A1B0GUE9;Q96N67-7;A0A0U1RQT6 Q96N67-2 DOCK7 Dedicator of cytokinesis protein 7 1 T(0.158)T(0.05)S(0.792)GDDACNLTSFRPATLTVTNFFK;T(0.172)T(0.05)S(0.775)GDDACNLT(0.003)SFRPATLTVTNFFK 119.29 4.2607e-08 66083000.0 1745.23 1829.8600000000001 1995.55 2387.83 2287.12 1712.3 2214.29 1837.4299999999998 881.26 1682.24 True False 1785.8904633735676 1615.6191405211653 1724.565270771518 1970.8403156204465 2080.250399823832 1695.0758166440066 2047.264322564893 1788.6953875862098 1495.4338553162124 1898.1718904052213 0.9408475978391588 0.8511448034225516 0.9085400955986964 1.0382833744312334 1.095923088071724 0.8930043823808508 1.0785452744892579 0.9423252955265076 0.787828469526523 1.0 10.89039492728802 -5.603157968294521 8.122122515060118 0.9797453585117297 0.8920195303069375 0.13736107150150523 0.08770030310848968 0.4589421576226311 40.54239404634692 0.02433128803877259 0.04227146757892641 2.493687519433766e-06 5.603157968294521 -0.08772582820479224 TTS(ph)PEPR ddPTM_A459_Selumetinib_30min_R2 1 TTSPEPR 7 0 Q96JM3 Q96JM3 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 1 T(0.029)T(0.029)S(0.942)PEPR 82.279 0.041457 13000000.0 30113.0 28525.0 34433.0 28901.0 29818.0 49005.0 85513.0 307750.0 50402.0 119780.0 True False 28439.440011890056 30712.77577766869 32217.618267815757 24964.63394299417 26071.99626369782 55754.993926901654 89489.5239407949 308645.5015492449 60483.80834954505 116321.64017418498 0.24448967508800276 0.26403320767896726 0.2769701168206683 0.21461727934381825 0.224137110039512 0.4793174670113983 0.7693282505885359 2.653379896355192 0.5199703877883257 1.0 16.82775999143488 -7.53064780499941 24.99964379564536 1.4942761011037238 0.30579566567359373 0.4841156112885958 0.5087756841991934 137.89088069035137 443704.38177276397 0.22175238491645177 0.128331971802306 2.94681040736711e-08 7.53064780499941 -1.18848043543013 TTS(ph)PLEEEER ddPTM_A459_Selumetinib_30min_R1 1 TTSPLEEEER 10 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 TT(0.065)S(0.935)PLEEEER 175.49 5.5605e-05 48246000.0 3023.1 3717.7 3190.1 2742.8 3253.3 3041.2 3335.2 3369.7 1743.7 3006.1 True False 3093.532348071391 3282.429955688161 2756.901941964983 2263.8214687326 2959.0395894167655 3010.6082891886676 3083.6231788150762 3280.3246096717958 2958.9315451908383 3391.962216893628 0.91201851620401 0.9677082897150379 0.812774956110733 0.6674076313284575 0.8723680867314215 0.8875712925675788 0.9090971483871864 0.9670876029615476 0.8723362337156689 1.0 11.727904384455952 -7.085487426719769 2.0166000032208102 0.9371821075453447 0.8423056161608695 0.23091154655746005 0.07891350032792646 0.5849934372235017 4.708180613658711 0.04017053512553169 0.029308870284576686 8.213203305743667e-08 7.085487426719769 -0.09487649138447518 TTS(ph)PLEEEER ddPTM_A459_Selumetinib_30min_R2 1 TTSPLEEEER 10 0 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 T(0.002)T(0.023)S(0.976)PLEEEER 202.31 0.00021485 71350000.0 197620.0 157880.0 183990.0 177770.0 222970.0 185200.0 160870.0 178930.0 135070.0 171530.0 True False 186637.07153553973 169988.88833578708 172152.28371316535 153557.4193296451 194958.5152229092 210709.61892178742 168350.77375785747 179450.65667654408 162087.77417112503 166577.48321153788 1.1204219678269964 1.0204793892816655 1.0334667110713156 0.9218377920540527 1.1703773611186696 1.2649345809493702 1.0106454396604592 1.077280393585119 0.9730473233605569 1.0 17.345833874813195 -8.256389511783212 23.591459477877468 0.9865236521673325 1.0760024114138866 0.14188502335178954 0.08937018870760191 387.5463247907787 1810546.6576347135 0.06959719055476819 0.024389677109413633 5.541285010198411e-09 8.256389511783212 0.08947875924655413 TTS(ph)PLEEEEREIK ddPTM_A459_Selumetinib_30min_R1 2 TTSPLEEEEREIK 13 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 T(0.261)T(0.062)S(0.678)PLEEEEREIK;T(0.041)T(0.187)S(0.772)PLEEEEREIK 105.99 0.024906 15990000.0 3858.8999999999996 3691.8999999999996 8552.9 8534.6 5257.5 5420.7 4163.6 3689.4 2640.38 2870.1 True False 3948.804861887696 3259.650631682254 7391.463157716785 7044.19232428367 4781.960053287014 5366.172679601806 3849.536299866411 3591.545127139842 4480.532014274809 3238.505292141446 1.219329445429613 1.006529351547493 2.2823687136324597 2.175136888421057 1.4765947935582857 1.6569905544460142 1.1886768594165007 1.1090132030523718 1.3835185093404863 1.0 11.661112386298079 -7.264713061195669 7.522613297073439 1.1784422297362382 1.6545817093400934 0.27242826287347 0.3721536863073011 0.19796181344398237 95.80426201609222 0.16551022020057166 0.11847311586032384 5.436093761345275e-08 7.264713061195669 0.47613947960385516 TTS(ph)PLEEEEREIK ddPTM_A459_Selumetinib_30min_R2 1 TTSPLEEEEREIK 13 1 S4R3H4;E7EQT4;Q9UKV3;Q9UKV3-5 S4R3H4;Q9UKV3-5 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 1 T(0.155)T(0.155)S(0.691)PLEEEEREIK 85.006 0.015608000000000004 13839000.0 29683.0 45184.0 40355.0 37008.0 38221.0 20249.0 10794.0 15203.0 12041.0 39550.0 True False 28033.337690463675 48649.46751054102 37758.60323520185 31967.446557639134 33419.336279924675 23038.115947879414 11295.942387905237 15247.238213007864 14449.536453650077 38408.08873675922 0.7298810904806574 1.2666464047189123 0.9830898770826947 0.8323102661196483 0.8701119316030959 0.5998245865806472 0.29410321521920024 0.3969798736279005 0.3762107652032386 1.0 15.22912255381665 -6.731443769425831 2.0810999385609827 0.4624229360986804 0.9765251993972175 0.44678483593160756 0.22286512747725326 0.2512909984339437 2.23888721108032 0.08452012490893619 0.07932362377459244 1.8559070887138425e-07 6.731443769425831 0.514102263298537 TTS(ph)PPEVSGYSYEK ddPTM_A459_Selumetinib_30min_R1 6 TTSPPEVSGYSYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.341)T(0.07)S(0.584)PPEVS(0.005)GYSYEK;T(0.338)T(0.055)S(0.607)PPEVSGYSYEK;TT(0.002)S(0.997)PPEVSGYSYEK;T(0.2)T(0.004)S(0.753)PPEVS(0.043)GYSYEK;T(0.009)T(0.009)S(0.982)PPEVSGYSYEK;T(0.007)T(0.041)S(0.952)PPEVSGYSYEK 203.74 3.1855e-05 3317871000.0 24453.5 28505.800000000003 30262.1 31160.600000000006 28568.699999999997 25266.0 26687.5 23554.6 14202.4 22596.300000000003 True False 25023.21897177196 25168.327684013108 26152.67303781652 25718.986166905717 25984.66612921366 25011.846979692502 24674.440388770483 22929.855491876227 24100.43549774524 25496.755211600932 0.9814275881029161 0.9871188500316154 1.0257255411824775 1.0087160485112894 1.0191361964910237 0.9809815708750343 0.9677482559641041 0.8993244552719879 0.9452353955525928 1.0 14.638026036908355 -7.252223994687261 2.4549296081603704 0.9417356737483281 1.0042173565502572 0.43688349059722087 0.02678896000560589 0.23904929757727822 2.837403132274472 0.01235938618547676 0.008247900984154224 5.5946897153193e-08 7.252223994687261 0.06248168280192912 TTS(ph)PPEVSGYSYEK ddPTM_A459_Selumetinib_30min_R2 1 TTSPPEVSGYSYEK 14 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 T(0.162)T(0.029)S(0.81)PPEVSGYSYEK 131.42 0.00089127 1002800000.0 297790.0 307810.0 375240.0 371170.0 436380.0 309400.0 318160.0 313410.0 302780.0 381590.0 True False 281240.0239478214 331418.03723485436 351097.4669304215 320616.0056960367 381558.0431133021 352017.0415464411 332955.07042207994 314321.9712121816 363344.4603800492 370572.50521011336 0.7589338658256884 0.8943406015698371 0.9474460786866807 0.8651910252063857 1.0296447732865663 0.9499275758379554 0.8984883274955748 0.8482064016971851 0.9804949241283676 1.0 18.499396318380178 -4.744421682146876 2.519747376508627 0.9340385030832405 0.7101607705789261 0.4988435169279022 0.05432028564856883 0.5211486702337847 3.863043459551304 0.014157513367484954 0.2639254063197532 1.801267934143947e-05 4.744421682146876 -0.22387773250431442 TTS(ph)PSSDTDLLDR ddPTM_A459_Selumetinib_30min_R2 1 TTSPSSDTDLLDR 13 0 Q96QT6;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7ERZ4;K7EJ43;K7ENU0 Q96QT6;K7ENU0 PHF12 PHD finger protein 12 1 T(0.099)T(0.011)S(0.878)PS(0.009)S(0.001)DT(0.003)DLLDR 213.18 3.5641000000000007e-06 19229000.0 43493.0 43282.0 41863.0 43527.0 49207.0 33234.0 33081.0 41217.0 33580.0 47640.0 True False 41075.833176273816 46601.59022643496 39169.58015698809 37598.54751173687 43025.17674383856 37811.68183178549 34619.33204875791 41336.93464615835 40296.93830359356 46264.50941641491 0.8878475897487822 1.0072859480035996 0.8466442344483286 0.8126866141240587 0.9299823403849383 0.8172934784945475 0.7482913465515918 0.8934912564206672 0.8710119011722618 1.0 15.49761827232061 -5.283431504227723 24.50396138755024 0.8557124412940125 0.9475667742288285 0.1698835408695365 0.0707656389409671 800.8712113254943 892342.0300522551 0.017933881836077352 0.03738374127567978 5.2067712213890765e-06 5.283431504227723 0.09185433293481604 TTS(ph)SANNPNLMYQDECDR ddPTM_A459_Selumetinib_30min_R2 1 TTSSANNPNLMYQDECDR 18 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 TT(0.003)S(0.779)S(0.218)ANNPNLMYQDECDR 259.55 1.4587999999999997e-42 3944500.0 5920.1 6041.9 6715.4 9000.3 8018.6 7535.2 8174.8 5546.5 6248.1 9879.0 True False 5591.084542037999 6505.294302229497 6283.338475174689 7774.443613616502 7011.231780806472 8573.105402264851 8554.944398058891 5562.639396727498 7497.894586500382 9593.767601275456 0.5827829872900699 0.6780750350221785 0.6549396166673187 0.8103639713539568 0.7308110923881828 0.8936119529438141 0.8917189527210918 0.5798180264433302 0.7815380670158785 1.0 13.227881776885637 -5.583815405895115 1.4244611372658065 0.8027636922501327 0.6105906408994228 0.34630552595163244 0.10795214971687862 0.6043391375167766 2.3373959099072343 0.03518108147761601 0.10733553475481371 2.6072615144249043e-06 5.583815405895115 -0.19217305135070983 TTS(ph)SSDLTTSSSSSGPR ddPTM_A459_Selumetinib_30min_R2 1 TTSSSDLTTSSSSSGPR 17 0 Q5QP82;A0A0A0MQT4 Q5QP82 DCAF10 DDB1- and CUL4-associated factor 10 1 T(0.043)T(0.173)S(0.707)S(0.058)S(0.019)DLTTSSSSSGPR 98.552 0.0051438000000000005 2394400.0 12347.0 10569.0 13125.0 15131.0 12470.0 11005.0 11473.0 13893.0 11720.0 10145.0 True False 11660.803168957147 11379.608315308687 12280.551789419513 13070.131697569106 10903.407116785556 12520.838856556524 12006.517233318204 13933.426329890037 14064.327484160698 9852.087490124455 1.1835870500181525 1.1550453979134259 1.246492360297176 1.3266357724360809 1.1067103421193654 1.2708818175952228 1.2186774879286555 1.4142613272422355 1.4275479687181536 1.0 13.266213724213154 -7.587875528266104 24.941373798841443 1.315837590725539 1.2163541184460591 0.03246060222023506 0.12442574036605056 127.07546355787572 48760.57719697666 0.0558712801545057 0.0322573007044855 2.5830003899266387e-08 7.587875528266104 -0.09948347227947996 TTSAT(ph)PLKDNTQQFR ddPTM_A459_Selumetinib_30min_R1 2 TTSATPLKDNTQQFR 15 1 Q14207 Q14207 NPAT Protein NPAT 1 T(0.004)T(0.001)S(0.073)AT(0.922)PLKDNTQQFR;TTSAT(0.977)PLKDNT(0.023)QQFR 136.14 0.004217 5214400.0 1104.27 1529.15 1832.73 1727.01 1467.92 1670.42 1532.45 6338.299999999999 1137.94 5015.3 True False 1129.9973424646214 1350.1164071174521 1583.8553324652783 1425.420123492739 1335.146895182325 1653.6170914200095 1416.8560627174274 6170.18769430001 1931.0010681507508 5659.062608158949 0.19967924384428062 0.2385759799106875 0.2798794503849023 0.2518827272625754 0.23593075172156214 0.29220689112644 0.25036939168594396 1.0903197440162875 0.3412227787278288 1.0 12.466347383203246 -7.739213871959372 24.997797600817027 0.7868283618499582 0.2516940343748986 0.6584030272177265 0.18484512660780913 126.76871401722384 142581.40645386715 0.07896712189052339 0.045546478540676824 1.8229977307118e-08 7.739213871959372 -0.5351343274750595 TTSESS(ph)SSPSASLK ddPTM_A459_Selumetinib_30min_R2 1 TTSESSSSPSASLK 14 0 Q96CB8;A0A087WXN4 Q96CB8 INTS12 Integrator complex subunit 12 1 TTSES(0.069)S(0.574)S(0.246)S(0.089)PS(0.022)ASLK 197.19 0.00010802 15215000.0 44902.0 35478.0 40401.0 43597.0 43241.0 36892.0 44957.0 47150.0 39151.0 39356.0 True False 42406.52659694775 38199.04852024995 37801.64364528288 37659.01339098012 37808.67900055528 41973.538127767686 47047.58958060546 47287.1986938973 46982.29397033918 38219.69002083174 1.109546586427937 0.9994599249609157 0.9890620155390846 0.9853301628153965 0.9892460922615429 1.0982176491983557 1.2309777906351949 1.237247049050458 1.2292693620678599 1.0 15.222028456995579 -7.006068379912643 3.7163863835807525 1.192982500506591 1.0114275522982308 0.5067089969071439 0.07329181716482909 0.16302634025403379 4.9271746553049445 0.02736947015794813 0.022317884286887833 9.861242075911017e-08 7.006068379912643 -0.18155494820836027 TTSESSS(ph)SPSASLK ddPTM_A459_Selumetinib_30min_R2 1 TTSESSSSPSASLK 14 0 Q96CB8;A0A087WXN4 Q96CB8 INTS12 Integrator complex subunit 12 1 TTSES(0.001)S(0.07)S(0.464)S(0.464)PSASLK 228.17 3.5218e-13 10845000.0 55778.0 34719.0 43617.0 51581.0 42724.0 46307.0 56614.0 46224.0 46477.0 43701.0 True False 52678.08205702529 37381.83566081962 40810.729706598926 44555.57881781195 37356.62916259392 52685.3689169071 59246.663178512805 46358.50418720483 55773.698675881955 42439.23858116597 1.2412588872507058 0.8808319119422005 0.9616272834053683 1.0498675355025144 0.8802379687172887 1.2414305882549044 1.39603501757465 1.092350045313447 1.3142012095531248 1.0 15.373111152083228 -6.777838561770912 24.94040156686358 1.2262772994621576 0.9963220856959697 0.3466104766756293 0.14028338168820345 237.87943839182492 361772.33858732483 0.0469986908703267 0.041566933639898024 1.6678670856583045e-07 6.777838561770912 -0.22995521376618788 TTSFFLNS(ph)PEKEHQEMDEGSQSLEK ddPTM_A459_Selumetinib_30min_R1 1 TTSFFLNSPEKEHQEMDEGSQSLEK 25 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 T(0.107)T(0.054)S(0.049)FFLNS(0.79)PEKEHQEMDEGS(0.001)QSLEK 59.912 0.0032215000000000004 17806000.0 1105.1 1889.8 1702.9 1950.0 1486.6 1623.7 1581.5 1468.9 787.57 1494.6 True False 1130.8466798497218 1668.541337455814 1471.6555333601355 1609.4691060334567 1352.1372924805464 1607.3670522016428 1462.2061817270458 1429.9400003403566 1336.4487681630728 1686.4464686368449 0.670550000181023 0.9893829234938577 0.872636968162811 0.9543552884512195 0.8017670988237648 0.9531088487504011 0.8670338542728531 0.8479012093969265 0.7924643877035271 1.0 10.7197708095655 -4.744941779322873 24.996223430451955 0.891648587863418 0.6705493622204205 0.4806395273856304 0.070568327593652 861.248652582673 1304844.789525847 0.016737067611131164 0.45051668931629746 1.7991120844447043e-05 4.744941779322873 -0.22109922564299755 TTSFFLNS(ph)PEKEHQEMDEGSQSLEK ddPTM_A459_Selumetinib_30min_R2 4 TTSFFLNSPEKEHQEMDEGSQSLEK 25 1 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 TTSFFLNS(0.998)PEKEHQEMDEGS(0.001)QSLEK;T(0.004)T(0.001)S(0.006)FFLNS(0.893)PEKEHQEMDEGS(0.08)QS(0.016)LEK;T(0.039)T(0.039)S(0.035)FFLNS(0.882)PEKEHQEMDEGS(0.004)QSLEK;T(0.1)T(0.1)S(0.11)FFLNS(0.686)PEKEHQEMDEGS(0.005)QS(0.001)LEK 92.39 1.5643e-05 29864900.0 136961.0 121742.0 129535.0 122595.0 118802.0 96161.0 111595.0 113481.0 84546.0 121462.0 True False 129349.25591832347 131079.21993777208 121200.85912704414 105897.34951182884 103877.03065664454 109406.30488735414 116784.38862129736 113811.21092220917 101457.56241261527 117955.07646382395 1.0965976183144102 1.1112639139187301 1.0275171087207564 0.8977769561643824 0.8806490892191735 0.9275251915156728 0.9900751381150973 0.9648691208056173 0.8601373120531327 1.0 16.847877983998366 -5.543580424560187 3.5731065659952375 0.9305980595498585 1.100643711559054 0.7247395027437951 0.04306483554889116 0.1179799536325848 3.204904189892759 0.012387689582575453 0.02477620628124768 2.8603526189141332e-06 5.543580424560187 0.1700456520091954 TTSIS(ph)PALAR ddPTM_A459_Selumetinib_30min_R1 1 TTSISPALAR 10 0 Q9UKE5-8;Q9UKE5-5;Q9UKE5-7;Q9UKE5-3;Q9UKE5-6;Q9UKE5-2;Q9UKE5-4;Q9UKE5 Q9UKE5-8 TNIK TRAF2 and NCK-interacting protein kinase 1 T(0.008)T(0.001)S(0.149)IS(0.842)PALAR 113.67 0.007486 7200300.0 2845.5 3246.8 2844.6 2856.1 3238.9 2763.1 3455.9 3043.7 1831.9 2872.1 True False 2911.7946136208357 2866.6631466036292 2458.318944269331 2357.3357506370053 2945.942066874241 2735.305722694069 3195.2186806389477 2962.971188669035 3108.6005033177153 3240.7620116230983 0.8984907263099202 0.8845645364646489 0.7585620096299852 0.7274016858326356 0.9090275855828117 0.8440316545564921 0.9859467215362289 0.9142822515328934 0.9592190022496618 1.0 11.662117363553646 -7.039154328903857 1.6578728150732536 0.9600849685100638 0.8236890601597082 0.5165440151882228 0.059384307154401135 0.3385678648629583 1.8675633726257526 0.030871762996908192 0.022557611745325657 9.137884640722394e-08 7.039154328903857 -0.13639590835035553 TTSIS(ph)PALAR ddPTM_A459_Selumetinib_30min_R2 1 TTSISPALAR 10 0 Q9UKE5-8;Q9UKE5-5;Q9UKE5-7;Q9UKE5-3;Q9UKE5-6;Q9UKE5-2;Q9UKE5-4;Q9UKE5 Q9UKE5-8 TNIK TRAF2 and NCK-interacting protein kinase 1 T(0.03)T(0.002)S(0.002)IS(0.966)PALAR 147.3 0.00082982 30367000.0 93338.0 72119.0 84496.0 83390.0 84687.0 85297.0 67203.0 74031.0 65104.0 80243.0 True False 88150.64762161831 77650.29540086549 79059.61935228869 72032.1381442262 74047.86194861408 97045.88750092694 70328.07266021827 74246.41795350818 78126.6191577473 77926.17609364765 1.1312071506714692 0.996459717304098 1.0145450901796969 0.9243638242644129 0.9502309193207067 1.245356725630964 0.9024961339781594 0.9527789207092964 1.002572217374798 1.0 16.249820403306657 -4.760855459590093 24.3433800878308 0.9986306855114995 1.1312073447583522 0.16422710735600932 0.08963898270086969 19.635086049232854 817597.864903502 0.02246623311634383 0.12943537979856165 1.7343811325286105e-05 4.760855459590093 0.1325766592468527 TTSPS(ph)SDTDLLDR ddPTM_A459_Selumetinib_30min_R1 1 TTSPSSDTDLLDR 13 0 Q96QT6;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7ERZ4;K7EJ43;K7ENU0 Q96QT6;K7ENU0 PHF12 PHD finger protein 12 1 T(0.001)T(0.28)S(0.28)PS(0.299)S(0.07)DT(0.07)DLLDR 139.48 0.00093275 27717000.0 2731.7 2824.7 3363.6 3181.6 2823.4 2458.6 3175.8 2791.2 1755.2 2530.5 True False 2795.3432950370866 2493.9828108325964 2906.8415949322634 2625.993286028743 2568.0239685117554 2433.8687162301917 2936.2468491487502 2717.1683089046264 2978.446205264069 2855.3143241573243 0.978996697977223 0.8734529819474898 1.0180460940285956 0.9196862369272568 0.8993839826267269 0.852399574939438 1.0283445238608926 0.951617930788244 1.0431237570116152 1.0 11.479433856499591 -7.284808194187641 24.99745306805775 1.001739717119485 0.9243848101438273 0.39083971241573745 0.05011348880427276 907.5928158706109 970841.2747570175 0.020790161196516995 0.014026108026276346 5.190292171578044e-08 7.284808194187641 -0.07735490697565772 TTSQAHSLPLS(ph)PASTR ddPTM_A459_Selumetinib_30min_R1 2 TTSQAHSLPLSPASTR 16 0 P19838-3;P19838;P19838-2 P19838-3 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 1 TTSQAHSLPLS(0.998)PAS(0.002)T(0.001)R;TTSQAHSLPLS(0.995)PAS(0.004)T(0.001)R 153.58 9.1844e-05 36713000.0 9777.0 10615.7 9817.3 12053.3 15885.5 10152.3 14104.8 11060.1 3604.2000000000003 7181.3 True False 10004.78507726969 9372.808908894958 8484.164582568827 9948.41742346312 14448.659329812823 10050.177079550864 13040.863580160365 10766.75021973203 6116.064159647196 8103.08980678561 1.234687670484854 1.1566956719455426 1.0470283293002751 1.2277313544189297 1.783104923471707 1.2402894845290673 1.6093692518673326 1.3287215712105085 0.7547817320900901 1.0 12.984256414750826 -8.251191377378547 24.033978627830074 0.8773908826666217 1.331570155822718 0.419059425162832 0.21240907191349387 368.85735034043984 865065.7898860623 0.15636719083307254 0.05750323354549207 5.608007975822574e-09 8.251191377378547 0.4541792731560963 TTSQAHSLPLS(ph)PASTR ddPTM_A459_Selumetinib_30min_R2 3 TTSQAHSLPLSPASTR 16 0 P19838-3;P19838;P19838-2 P19838-3 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 1 TTSQAHSLPLS(0.847)PAS(0.076)T(0.076)R;TTSQAHS(0.005)LPLS(0.972)PAS(0.011)T(0.011)R;TTSQAHSLPLS(0.959)PAS(0.009)T(0.032)R 135.23 0.00027316 51909000.0 103954.0 85775.0 135134.0 175189.0 191163.0 111787.0 97919.0 106082.0 116290.0 154673.0 True False 98176.65284083337 92353.66668990479 126439.62556277472 151327.95598211873 167147.39492109694 127184.64454864923 102472.42752281752 106390.68105717949 139551.24941408285 150207.18860128365 0.6536082177893473 0.6148418564377254 0.841768138663466 1.0074614763199523 1.112778932070822 0.8467280809459363 0.6822072130970023 0.7082928723177653 0.9290583940327491 1.0 17.196594333302663 -5.322379695369785 4.6841063315694 0.8859495797597544 0.6332069959085547 0.4040879342296687 0.1253595865722806 0.22867425683757103 10.26891381938954 0.037789352335086644 0.08485294116001882 4.760146343253028e-06 5.322379695369785 -0.25274258385119974 TTSSANNPNLMYQDECDRR ddPTM_A459_Selumetinib_30min_R1 1 TTSSANNPNLMYQDECDRR 19 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 103.66 0.0048669 25743000.0 1876.2 2849.1 2641.9 3013.9 2318.4 2224.1 2614.3 2096.2 1472.2 1691.5 False True 1919.9118095503102 2515.5260474893444 2283.14449091793 2487.578942909865 2108.701129346764 2201.727573321227 2417.101246214994 2040.6019665827862 2498.215874766274 1908.620501605261 1.0059159523517391 1.3179812568154017 1.1962275837431655 1.3033386892877166 1.1048299688561574 1.153570115939468 1.2664127018346867 1.0691501871988283 1.3089117887317718 1.0 10.898314559284858 -6.28894624152169 24.947123203904255 1.159887876333146 1.213185719188695 0.0474677931214027 0.11523125439687283 2511.0822136113948 2277395.848253116 0.03368976547017696 0.03821114272510288 5.141072856280911e-07 6.28894624152169 0.05329784285554906 TTSVSLTIGSS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 TTSVSLTIGSSSPK 14 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;D6RBB1;H0Y952;Q8WX93-6;D6RBH5;D6R9Z5 Q8WX93 PALLD Palladin 1 TTSVSLTIGS(0.05)S(0.475)S(0.475)PK 128.36 0.0011406 9189900.0 2032.7 2089.6 3055.7 2789.5 1882.0 2203.5 2398.8 1915.2 1512.4 2184.3 True False 2080.0579550543207 1844.9486605713146 2640.7527237586282 2302.366190400169 1711.7734322940864 2181.3347906179238 2217.8565847150408 1864.4026745536466 2566.4323386744404 2464.6761818837545 0.8439477649613712 0.7485562095874269 1.0714400306089291 0.9341455106043458 0.6945226496187326 0.8850391003294913 0.899857190578249 0.7564493414013852 1.0412858117178354 1.0 11.267182397196953 -8.280566458432267 24.705826577832795 1.0206429647315243 0.8578478012583871 0.2984471961056968 0.1019284171303507 1066.8341349053526 1377979.7048614419 0.09944825584833811 0.025842522450735688 5.241233902630931e-09 8.280566458432267 -0.16279516347313716 TTSVSLTIGSSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 TTSVSLTIGSSSPK 14 0 Q8WX93;Q8WX93-3;Q8WX93-5;Q8WX93-9;Q8WX93-2;Q8WX93-8;D6RBB1;H0Y952;Q8WX93-6;D6RBH5;D6R9Z5 Q8WX93 PALLD Palladin 1 TTSVSLTIGSS(0.063)S(0.937)PK;TTSVSLTIGS(0.001)S(0.146)S(0.853)PK 281.6 1.0998e-54 8309400.0 93342.0 87402.0 79716.0 76649.0 77566.0 59782.0 89377.0 72905.0 51442.0 70579.0 True False 88154.42531763163 94105.45235827526 74587.15934821843 66209.2739731 67821.46563116182 68016.42785303609 93533.2075971656 73117.14147992746 61731.83740957293 68541.20088373512 1.286152331459234 1.3729764163003826 1.0882091119870942 0.9659777348431535 0.9894992319467211 0.9923436849087429 1.3646274998277876 1.0667618970370014 0.9006529884745854 1.0 16.064683848526933 -5.320344957036394 5.396074959919495 1.0511953593128935 1.3295072772989 0.4747114406566102 0.11950274638728518 0.17784552478622404 10.962039921452211 0.033429573265257494 0.07295794672566737 4.782500707685501e-06 5.320344957036394 0.2783119179860065 TTT(ph)SPFFSEDTFR ddPTM_A459_Selumetinib_30min_R2 1 TTTSPFFSEDTFR 13 0 A0A5F9ZHK5;A0A5F9ZGT0;H0Y9K9;G5E9Z1;A0A590UJE4;A0A494C0H4;H0Y9M2;Q17R98-3;Q17R98-2;Q17R98 A0A5F9ZHK5 ZNF827 Zinc finger protein 827 1 T(0.143)T(0.002)T(0.417)S(0.417)PFFS(0.022)EDTFR 176.99 0.00024031 4149900.0 20696.0 18462.0 21999.0 26362.0 25465.0 18100.0 19880.0 17774.0 17291.0 23177.0 True False 19545.79917265222 19877.97603531356 20583.60829070017 22771.450123013474 22265.859040011557 20593.110704559127 20804.459391472676 17825.7193973559 20749.68315090638 22507.819788922083 0.8684003762226801 0.8831586631547992 0.9145092009680577 1.0117128329871001 0.9892499250847204 0.9149313837448912 0.9243213952562492 0.7919789461851555 0.9218877414825837 1.0 14.458138697023736 -10.30438731736309 14.944405252379886 0.9999999292216883 0.9144209924613739 0.16845159204044668 0.057711692953730444 0.0 0.0 0.061375284837666085 0.014885693069886317 4.961496423579361e-11 10.30438731736309 -0.08557893676031447 TTTAAAVASTGPS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 TTTAAAVASTGPSSR 15 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 TTTAAAVAS(0.002)T(0.002)GPS(0.868)S(0.127)R 113.52 0.0027419 3954900.0 3015.4 3940.7 3932.6 4489.2 3518.0 3262.1 3918.2 3212.2 1831.0 3142.1 True False 3085.6529530529815 3479.3210120182716 3398.5745202255375 3705.245492720715 3199.7975211533458 3229.2862357498207 3622.647019439084 3127.0020213038983 3107.073269051112 3545.4191416458116 0.870321062129934 0.9813567516316684 0.9585818726775115 1.0450796773779223 0.902516005390543 0.9108334182036262 1.0217824394543722 0.8819837363015757 0.8763627500495708 1.0 11.791740478510182 TTTAAAVASTGPS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 TTTAAAVASTGPSSR 15 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 TTTAAAVAS(0.001)T(0.008)GPS(0.892)S(0.099)R 112.17 0.0030735 2950900.0 7652.7 9033.6 8416.0 7166.7 9102.3 5626.4 4806.7 5778.8 5655.2 9046.3 True False 7227.393570185337 9726.448072397823 7874.523722647966 6190.583096752924 7958.7876984055465 6401.385528626043 5030.221074295357 5795.615351268158 6786.39801949024 8785.10981388988 0.8226867646842976 1.1071515642319714 0.8963489232881059 0.7046676965796346 0.9059406048427694 0.7286631202384062 0.5725848829279541 0.6597089249931606 0.7724886954469783 1.0 13.100844604699287 -5.609656846665468 4.684708988504969 0.7465088365535191 0.9734493226362939 0.2824403261821996 0.13090152457629778 0.22364135697585738 8.662236879797687 0.035779711340981804 0.06423106778894726 2.4566492452454436e-06 5.609656846665468 0.22694048608277484 TTTAAAVASTGPSS(ph)RSPSTLLPK ddPTM_A459_Selumetinib_30min_R2 1 TTTAAAVASTGPSSRSPSTLLPK 23 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 TTTAAAVAS(0.001)T(0.004)GPS(0.086)S(0.428)RS(0.428)PS(0.027)T(0.027)LLPK 80.236 0.00031861 29963000.0 44166.0 79646.0 58660.0 70800.0 55606.0 31833.0 16586.0 12743.0 10995.0 62634.0 True False 41711.430530506266 85754.59209774602 54885.879464178885 61156.91786318776 48620.27715605273 36217.70679879723 17357.281864535504 12780.080020282781 13194.307225968165 60825.59367732431 0.6857545978389065 1.4098438981568906 0.9023484383127404 1.0054471179947886 0.7993391303992862 0.595435319397452 0.28536148708411657 0.21011023892475672 0.21692031969244852 1.0 15.892390875948696 -6.72926426569034 1.7271751260246853 0.3645083592505543 1.0270955755270894 0.4655113727388972 0.27288138915968413 0.2702699619686527 1.6678678723821265 0.10843303912592496 0.10137937587492953 1.865244355002389e-07 6.72926426569034 0.6625872162765352 TTTAAAVASTGPSSRS(ph)PSTLLPK ddPTM_A459_Selumetinib_30min_R1 2 TTTAAAVASTGPSSRSPSTLLPK 23 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 TTTAAAVASTGPS(0.001)S(0.005)RS(0.587)PS(0.203)T(0.203)LLPK;TTTAAAVAS(0.001)T(0.002)GPS(0.001)S(0.002)RS(0.992)PS(0.002)T(0.001)LLPK 131.78 3.9982e-06 326650000.0 2894.3999999999996 2455.32 7845.799999999999 8582.9 4770.9 4162.2 3518.0 3047.3199999999997 1968.6200000000001 2417.19 True False 2961.833888477998 2167.849992952699 6780.383453894503 7084.0576359869565 4339.3729373708065 4120.332046975229 3252.6344276419504 2966.4951745096187 3340.604357683999 2727.459881924459 1.085931238844902 0.7948237872606556 2.485970004116195 2.59730956372071 1.5909942309798535 1.5106847489422937 1.192550786612097 1.0876402597777166 1.2248042142885391 1.0 11.413342260835426 -7.093631318769953 2.194910698563518 1.120842707328718 1.749460393488183 0.2233948754452305 0.5157557004211453 0.5587242074774347 5.306346734911391 0.26232901469552367 0.192890796842579 8.060624332745197e-08 7.093631318769953 0.628617686159465 TTTAAAVASTGPSSRS(ph)PSTLLPK ddPTM_A459_Selumetinib_30min_R2 1 TTTAAAVASTGPSSRSPSTLLPK 23 1 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 TTT(0.001)AAAVAS(0.011)T(0.051)GPS(0.056)S(0.051)RS(0.714)PS(0.05)T(0.066)LLPK 65.184 0.0024507 32839000.0 53501.0 102450.0 81357.0 94507.0 82387.0 44432.0 29923.0 26765.0 17829.0 91967.0 True False 50527.62860147211 110307.58557132877 76122.57919480401 81634.98356633165 72036.80851087507 50552.10468646247 31314.478791299636 26842.88171881572 21395.298183882336 89311.67375103763 0.5657449522480266 1.2350858621104637 0.8523250768651015 0.9140460606963288 0.8065777460590715 0.5660190047202553 0.35062022103169715 0.3005528906964848 0.23955768921678913 1.0 16.446561139017028 -6.795303584477176 2.280027674054683 0.4154256372040422 0.911502361969125 0.36929466662461685 0.24904897232798096 0.26884122744395844 2.8676821514257047 0.09272706068542365 0.08373569112050576 1.602125067135959e-07 6.795303584477176 0.49607672476508285 TTTLSGTAPAAGVVPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 TTTLSGTAPAAGVVPSR 17 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 T(0.234)T(0.008)TLSGT(0.047)APAAGVVPS(0.71)R 96.666 0.005901399999999999 2151200.0 8932.6 9449.0 10054.0 9478.2 9928.2 7573.2 8292.1 8106.8 4828.8 8654.3 True False 8436.161852030991 10173.707916676301 9407.13658596752 8187.252809193014 8680.930756765869 8616.3395573352 8677.699080484435 8130.389445847012 5794.694927944981 8404.427872428203 1.0037758643520394 1.210517607040504 1.1193071948215334 0.9741594470757897 1.032899667715011 1.0252142903864048 1.0325151470396614 0.9673935655417772 0.6894811896661301 1.0 13.036933896663149 -7.9880852934639845 4.053070980613372 0.8375523295174486 1.058483923251859 0.44329413150550845 0.09413895033588404 0.17875136697412014 6.688635283299954 0.061313398576758354 0.0247814159521412 1.0278144202186522e-08 7.9880852934639845 0.2209315937344104 TTTPPPSQIPDPPFS(ph)SPITPHR ddPTM_A459_Selumetinib_30min_R2 1 TTTPPPSQIPDPPFSSPITPHR 22 0 Q6ZS30-1;Q6ZS30 Q6ZS30-1 NBEAL1 Neurobeachin-like protein 1 1 TTTPPPSQIPDPPFS(0.529)S(0.357)PIT(0.114)PHR 94.087 0.00016239 3765700.0 9249.9 8715.2 11308.0 12750.0 12126.0 6687.9 7689.6 6688.8 4893.3 7997.2 True False 8735.827588283528 9383.627816215183 10580.455591219488 11013.428005023203 10602.623472184576 7609.097518288442 8047.18163665333 6708.263300609553 5872.096730225559 7766.300056779037 1.1248377637248526 1.2082494556754109 1.3623547266866203 1.4181048793511162 1.3652090950219948 0.9797583743428281 1.0361667174614402 0.8637656608121976 0.7560996468453381 1.0 12.923011732581214 -6.844909382025023 4.707966810534437 0.9168376134526498 1.3011992619288992 0.75197989503295 0.10611206648555117 0.11620298547459575 4.601541184322968 0.04222476447126055 0.037492059440176605 1.4291921363421358e-07 6.844909382025023 0.38436164847624943 TTTPPPSQIPDPPFSS(ph)PITPHR ddPTM_A459_Selumetinib_30min_R2 2 TTTPPPSQIPDPPFSSPITPHR 22 0 Q6ZS30-1;Q6ZS30 Q6ZS30-1 NBEAL1 Neurobeachin-like protein 1 1 TTTPPPSQIPDPPFS(0.241)S(0.672)PIT(0.087)PHR;TTTPPPSQIPDPPFS(0.244)S(0.666)PIT(0.09)PHR 103.74 5.3607e-05 12780300.0 26210.0 22436.0 27475.1 33942.8 36634.0 20085.8 19712.7 25846.0 19939.4 21520.2 True False 24753.353126943133 24156.769056889567 25707.38197862705 29319.73208540406 32031.709407884682 22852.4366292615 20629.379609974014 25921.20758096436 23927.837153385142 20898.85590980545 1.18443580039849 1.1558895453963847 1.2300856127997661 1.402934792791583 1.5327015768770316 1.0934778787837596 0.9871056912878661 1.2403170629451774 1.1449352661529446 1.0 14.351136344897292 TTTS(ph)PFFSEDTFR ddPTM_A459_Selumetinib_30min_R2 1 TTTSPFFSEDTFR 13 0 A0A5F9ZHK5;A0A5F9ZGT0;H0Y9K9;G5E9Z1;A0A590UJE4;A0A494C0H4;H0Y9M2;Q17R98-3;Q17R98-2;Q17R98 A0A5F9ZHK5 ZNF827 Zinc finger protein 827 1 TTT(0.286)S(0.703)PFFS(0.006)EDT(0.006)FR 119.25 0.0032645000000000005 4574800.0 21128.0 19156.0 19626.0 20360.0 23753.0 16172.0 19957.0 19063.0 16887.0 17988.0 True False 19953.790342085256 20625.203603751834 18363.28452717312 17586.932877040974 20768.935785485737 18399.546205200542 20885.04004404529 19118.470173950456 20264.871862203217 17468.639701563203 1.1422635467316706 1.1806988956275835 1.051214338431278 1.0067717451100204 1.1889269078935323 1.0532901542158453 1.1955733474871753 1.0944452745361515 1.1600715458336341 1.0 14.092479648238148 -12.044284935448465 1.78444687455738 5.625518040693114e-05 1.1173732087585455 0.246956056181024 0.06239396520046504 1278533.0380898395 76632.19255045861 5162712.633368343 0.015592319875180753 9.030567944876332e-13 12.044284935448465 1.1173169535781386 TTWGDGGENS(ph)PCNVVSK ddPTM_A459_Selumetinib_30min_R2 2 TTWGDGGENSPCNVVSK 17 0 H3BM38;H3BV99;H3BP15;H3BQY9;O00161 H3BM38 SNAP23 Synaptosomal-associated protein;Synaptosomal-associated protein 23 1 T(0.003)T(0.001)WGDGGENS(0.956)PCNVVS(0.041)K;TTWGDGGENS(1)PCNVVSK 161.31 2.165e-05 23097000.0 195842.0 71767.0 133710.0 144822.0 93619.0 80865.0 222296.0 147783.0 93028.0 96970.0 True False 184957.88565764204 77271.29813272398 125107.24417244032 125096.99376811514 81857.74425552093 92003.41973061733 232633.20447116747 148213.02406320718 111636.1994194966 94170.22414168245 1.9640803379565743 0.8205491580487965 1.3285223149114738 1.3284134651724122 0.8692529406361297 0.9769905569322519 2.470347783405108 1.5738841593943262 1.1854723766138218 1.0 16.52298334306245 TTYDS(ph)AEEENKENLYAGK ddPTM_A459_Selumetinib_30min_R1 1 TTYDSAEEENKENLYAGK 18 1 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 T(0.166)T(0.045)Y(0.013)DS(0.775)AEEENKENLYAGK 73.44800000000002 0.0098116 19952000.0 4397.6 4747.7 4658.8 4744.5 3824.9 3996.8 4626.2 4249.8 2673.1 4055.6 True False 4500.055523759968 4191.837076854148 4026.160548956605 3915.9621402952525 3478.938470340942 3956.5958208040474 4277.242009425015 4137.0814987041 4536.055464500562 4576.175764889325 0.9833659708367434 0.9160131280393526 0.8798089837036619 0.8557280885800854 0.7602283323628152 0.864607485394464 0.9346760765270692 0.9040477707272145 0.9912327885881076 1.0 12.159926749860642 -8.09845525579737 1.406069378216557 1.0027820423177454 0.8759803972321513 0.3901293361217203 0.05472181969346809 0.4704467107423568 1.6855615670609858 0.05532421040554735 0.017943946411967296 7.971586154865769e-09 8.09845525579737 -0.1268016450855941 TTYDS(ph)AEEENKENLYAGK ddPTM_A459_Selumetinib_30min_R2 2 TTYDSAEEENKENLYAGK 18 1 E7ESG2;Q9HAW4-2;Q9HAW4-3;Q9HAW4 E7ESG2 CLSPN Claspin 1 T(0.007)T(0.002)Y(0.042)DS(0.948)AEEENKENLYAGK;T(0.004)T(0.002)Y(0.008)DS(0.986)AEEENKENLYAGK 86.772 0.0039216 62613000.0 60148.0 51881.0 48655.0 61720.0 55356.0 49374.0 53955.0 57649.0 43572.0 58334.0 True False 56805.21495152137 55860.10587629202 45524.59027155857 53313.62952706137 48401.68439108112 56174.820327453155 56464.01440980426 57816.74904569429 52287.617503400164 56649.745850066014 1.002744391861295 0.9860610147155131 0.8036150840296403 0.9411097742285678 0.8544024984540106 0.9916164580178376 0.9967214073518824 1.0206003253521554 0.9229982715507493 1.0 15.7897818631915 -6.8012092697778685 24.956831437370386 0.9883207831698956 0.9163657538718099 0.2522061569785956 0.059169219387310484 222.4390993467166 139585.85815534898 0.021325010258 0.018807136142423773 1.5804862803101545e-07 6.8012092697778685 -0.07195502929808573 TTYLVLDEADR ddPTM_A459_Selumetinib_30min_R2 1 TTYLVLDEADR 11 0 P17844-2;P17844;J3KTA4;J3QSF1;J3KRZ1 P17844-2 DDX5 Probable ATP-dependent RNA helicase DDX5 0 137.46 0.018441 2300800.0 12675.0 13577.0 13181.0 13891.0 14539.0 8758.2 14997.0 13347.0 12216.0 10633.0 False True 11970.574242045173 14618.312243064252 12332.948810387697 11999.021836688422 12712.48083969088 9964.562550976229 15694.39021599173 13385.837560285201 14659.541343558625 10325.997662148187 1.1592656355061437 1.4156803750450497 1.1943590550670327 1.1620205842843647 1.231114053636752 0.964997560236057 1.5198909325267773 1.2963238999514217 1.4196731224621353 1.0 13.33399355612882 -7.274467162242772 24.990405326098177 1.3336656134062486 1.199340254081318 0.10923743927696383 0.1614177844979852 1610.6719614783349 3089640.63231362 0.06477686625667121 0.04398272389879175 5.3153618835816336e-08 7.274467162242772 -0.1343253593249305 TVAISDAAQLPHDY(ph)CTTPGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R2 1 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 1 TVAISDAAQLPHDY(0.728)CT(0.07)T(0.195)PGGT(0.004)LFS(0.001)T(0.001)TPGGTR 80.733 8.7395e-05 3530200.0 5902.0 5940.6 6532.0 7395.5 7097.5 6085.0 5039.4 5898.2 6451.1 7529.0 True False 5573.990467577958 6396.224917960336 6111.738231503866 6388.220142050911 6205.8485975449485 6923.153515869735 5273.742085381657 5915.362785500423 7741.500258794293 7311.618207308726 0.7623470358457958 0.8748029145677548 0.8358940604139512 0.8737081123389646 0.8487654061780133 0.9468702166299275 0.7212824761705967 0.8090360598406794 1.058794378931856 1.0 12.835975023438403 -8.261237057995727 24.999997850604416 1.0293972085152467 0.8373147317367837 0.6255944985033485 0.06039627597348632 11.580369574937773 1431457.17959975 0.0473833090690289 0.015293944558331144 5.479777716832675e-09 8.261237057995727 -0.19208247677846302 TVAISDAAQLPHDYCT(ph)T(ph)PGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R1 3 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 2 TVAISDAAQLPHDY(0.565)CT(0.503)T(0.511)PGGT(0.134)LFS(0.107)T(0.101)T(0.07)PGGT(0.009)R;TVAISDAAQLPHDY(0.012)CT(0.683)T(0.683)PGGT(0.152)LFS(0.152)T(0.152)T(0.152)PGGT(0.013)R;TVAISDAAQLPHDY(0.055)CT(0.552)T(0.542)PGGT(0.192)LFS(0.201)T(0.201)T(0.201)PGGT(0.057)R 97.839 1.5819000000000002e-07 136527000.0 3290.92 4469.84 3955.59 4285.9400000000005 4112.16 3977.2200000000003 4635.9400000000005 3703.99 2133.2999999999997 3694.5 True False 3367.592032984389 3946.5090548277612 3418.442604500571 3537.4810360579695 3740.215854060813 3937.212777826827 4286.247313383294 3605.7481529448437 3620.0542899326806 4168.725062477467 0.8078230112357264 0.946694491884374 0.8200211223498141 0.8485762392676599 0.8972085704874978 0.9444644870599711 1.0281914132365408 0.8649522573220392 0.8683840348495633 1.0 12.025390510710986 -6.538456240613695 3.6231256286971205 0.9377613211291473 0.8603036209435959 0.31923219185432994 0.05851404202824598 0.3258731530860321 9.245878334290706 0.020249520019262383 0.021241951116316597 2.894301431347873e-07 6.538456240613695 -0.07745770018555143 TVAISDAAQLPHDYCT(ph)TPGGTLFS(ph)TTPGGTR ddPTM_A459_Selumetinib_30min_R1 2 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 2 TVAISDAAQLPHDY(0.211)CT(0.397)T(0.397)PGGT(0.078)LFS(0.248)T(0.248)T(0.306)PGGT(0.115)R;TVAISDAAQLPHDY(0.374)CT(0.363)T(0.363)PGGT(0.029)LFS(0.276)T(0.276)T(0.276)PGGT(0.044)R 82.139 2.8043e-05 13509000.0 2170.3900000000003 2249.02 2524.19 2921.04 2830.34 2260.29 2436.29 2342.9300000000003 1487.6399999999999 1832.21 True False 2220.955864156221 1985.7036928589682 2181.418862383183 2410.9351987117802 2574.3362467371144 2237.553534779118 2252.5186838316695 2280.7878854907967 2524.4164270732927 2067.392000736727 1.074279025634602 0.9604872671227089 1.0551549302724503 1.1661722585037717 1.245209542176682 1.0823073388993247 1.089545999514834 1.1032198463948903 1.2210632652993252 1.0 11.013596250541742 -5.595407109495179 5.077586939575209 1.1346193875163664 1.0149826305532028 0.2961967423581152 0.07152553201531055 0.22148891940257204 10.482177953697411 0.019409093104995938 0.034677728053582865 2.5385919029853197e-06 5.595407109495179 -0.11963675696316356 TVAISDAAQLPHDYCT(ph)TPGGTLFSTTPGGTR ddPTM_A459_Selumetinib_30min_R2 1 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 1 TVAISDAAQLPHDY(0.019)CT(0.309)T(0.309)PGGT(0.122)LFS(0.101)T(0.101)T(0.029)PGGT(0.01)R 53.545 0.0068920000000000006 3033200.0 6303.8 6524.9 3922.2 3489.2 6609.1 3635.5 4453.3 4319.5 3113.4 4654.6 True False 5953.460032110798 7025.33884913972 3669.849922168469 3013.9649407942734 5778.805771896347 4136.257125216832 4660.387274046542 4332.0690298682775 3736.1669956643295 4520.209603896828 1.3170760990769939 1.554206433941303 0.8118760508372725 0.6667754827554819 1.2784375677876743 0.9150587002981023 1.0310113208088554 0.9583779093194358 0.8265472894096364 1.0 12.14217395719001 -5.2607847447867835 24.999188110772124 0.9397826361912671 1.435641291792011 0.6061694718409215 0.16106636422252857 36.93816246625391 1410518.965764589 0.041989233801868704 0.09847362669322485 5.4854878216129105e-06 5.2607847447867835 0.4958586556007438 TVAISDAAQLPHDYCTTPGGT(ph)LFSTTPGGTR ddPTM_A459_Selumetinib_30min_R2 1 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 1 TVAISDAAQLPHDYCT(0.001)T(0.013)PGGT(0.492)LFS(0.118)T(0.118)T(0.173)PGGT(0.084)R 75.018 4.4308e-05 8557800.0 13128.0 10159.0 15207.0 15911.0 13494.0 7096.4 9769.8 9632.8 8936.2 12568.0 True False 12398.398315547862 10938.162633666478 14228.598176129708 13743.89435199406 11798.7630821094 8073.864685294657 10224.11505849144 9660.829853204114 10723.689698289832 12205.129184414402 1.0158350745996412 0.8961939253895155 1.165788412489662 1.126075287227981 0.9667053010119779 0.6615140702979817 0.8376900321175903 0.7915385168999862 0.8786215644471568 1.0 13.575199944863328 -6.533531263123816 24.03005246930585 0.8203077263853771 1.0479025775804687 0.49735394438958436 0.10299851289812399 107.95868792330731 243531.52216766315 0.03401523076566199 0.034053826619487276 2.927310138428627e-07 6.533531263123816 0.2275948511950916 TVAISDAAQLPHDYCTTPGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R1 2 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 1 TVAISDAAQLPHDYCT(0.009)T(0.009)PGGT(0.126)LFS(0.198)T(0.145)T(0.367)PGGT(0.145)R;TVAISDAAQLPHDYCT(0.001)T(0.001)PGGT(0.055)LFS(0.169)T(0.169)T(0.525)PGGT(0.08)R 129.23 5.9475e-18 93868000.0 4526.1 5048.8 5563.8 6697.5 5932.6 5065.4 5443.1 4757.700000000001 2606.7 4295.1 True False 4631.549323742492 4457.68414887656 4808.266519765767 5527.9073526456805 5395.997377485599 5014.446675015215 5032.522584735048 4631.510340812387 4423.379514164684 4846.417922816881 0.9556644510448035 0.9197894650995394 0.9921279172249059 1.1406171404699448 1.1133991049515775 1.0346707103832824 1.0384004567666334 0.9556564073864303 0.9127111166660768 1.0 12.242703103231388 -10.536092152479073 10.635887262073194 0.9999913217012433 1.0112873974194676 0.0 0.07285591278890069 0.0 0.0 0.07959760937384916 0.019305255940884385 2.910099561653153e-11 10.536092152479073 0.01129607571822433 TVAISDAAQLPHDYCTTPGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R2 2 TVAISDAAQLPHDYCTTPGGTLFSTTPGGTR 31 0 Q13542 Q13542 EIF4EBP2 Eukaryotic translation initiation factor 4E-binding protein 2 1 TVAISDAAQLPHDY(0.002)CT(0.005)T(0.005)PGGT(0.185)LFS(0.148)T(0.148)T(0.36)PGGT(0.148)R;TVAISDAAQLPHDYCT(0.003)T(0.012)PGGT(0.079)LFS(0.194)T(0.194)T(0.498)PGGT(0.02)R 117.94 8.9526e-16 22155200.0 41580.0 40081.0 46751.0 55054.0 46896.0 29193.0 37644.0 36155.0 30285.0 37631.0 True False 39269.15005792807 43155.083819272164 43743.09155864011 47555.55022655277 41004.50522444067 33214.07076233119 39394.52059017087 36260.20506421752 36342.846233601274 36544.49525292002 1.07455718805667 1.1808915000905351 1.196981686459191 1.301305433210298 1.1220432773979625 0.9088665894127318 1.0779878150601387 0.9922207110336327 0.9944820959238002 1.0 15.15736648697433 -6.558048533053383 7.373214449097054 1.0004754943709775 1.1914389956793223 0.6770366104743053 0.06356388782157546 0.1197470047261581 19.7889131495368 0.021094092273118755 0.021231965183789957 2.766632452849758e-07 6.558048533053383 0.19096350130834483 TVANLLSGKS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 TVANLLSGKSPR 12 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 TVANLLS(0.029)GKS(0.971)PR;TVANLLSGKS(1)PR 173.33 0.00089312 1061210000.0 3968.3 4715.5 5792.6 6232.9 4899.799999999999 3965.9 4459.7 3668.6000000000004 2795.0 3380.4 True False 4060.7536690323514 4163.407067823523 5005.996736474208 5144.441021023556 4456.613955129949 3926.0066467490897 4123.301238474932 3571.2968107077627 4742.9108612768205 3814.307267884377 1.0646110509300073 1.0915237749403381 1.3124261851224186 1.3487222343985263 1.1683940600836362 1.0292843158717697 1.0810091974477818 0.9362897532606488 1.243452749916369 1.0 11.897205351699593 -6.647735756638039 5.043558593411315 1.0560044854501622 1.2099226656607138 0.29122420176847175 0.10916304651553528 0.2797162933961596 11.224425406543956 0.03828325786554526 0.038084332966125144 2.2504234433638321e-07 6.647735756638039 0.1539181802105516 TVANLLSGKS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 TVANLLSGKSPR 12 1 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;A0A2R8Y857;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8 E7ETY2;Q13428 TCOF1 Treacle protein 1 TVANLLS(0.023)GKS(0.977)PR;TVANLLS(0.001)GKS(0.999)PR 111.7 0.0036782 1177000000.0 961960.0 1048920.0 1015320.0 1060410.0 1159500.0 725710.0 671850.0 735110.0 585910.0 890720.0 True False 908498.1142309881 1129368.791190611 949995.4165968332 915980.3286907193 1013833.2439384797 825669.9651605292 703092.3562455183 737249.0483959878 703108.3716932243 865002.5992315096 1.0502836812723118 1.3056247370747451 1.098257297077296 1.0589336141931824 1.1720580317783957 0.9545288833745419 0.812821090792286 0.8523084775132221 0.812839605705097 1.0 19.72234494232233 -6.9125315793829865 3.6597617384052796 0.8588325122360189 1.1399064811942832 0.6975537263443308 0.08362651517069628 0.12382896507881504 3.245488186702409 0.030564179804399263 0.026447657855790386 1.223118177736328e-07 6.9125315793829865 0.2810739689582643 TVART(ph)PLGQR ddPTM_A459_Selumetinib_30min_R1 1 TVARTPLGQR 10 1 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 TVART(1)PLGQR 132.17 0.025758 82806000.0 4441.3 4753.5 7289.8 8544.1 6532.1 5474.5 5529.8 4313.0 2698.6 3557.3 True False 4544.773648734568 4196.958010157801 6299.885200005119 7052.033327620753 5941.272708335922 5419.431500448297 5112.68273393248 4198.605229401568 4579.3271020542525 4013.9141060362977 1.1322548337294864 1.0456023470572613 1.5695117119051152 1.7568969193973534 1.4801693686970478 1.3501613032272717 1.2737399453176654 1.0460127243598771 1.1408632524466984 1.0 11.970794029384207 -7.554612228111906 2.1714866842528053 1.062571008303155 1.4043330485644625 0.36052281332522096 0.19350685692680467 0.409462227257027 3.8406834617987338 0.1307561413276279 0.06652959557768229 2.788609945204295e-08 7.554612228111906 0.3417620402613075 TVAS(ph)DLQK ddPTM_A459_Selumetinib_30min_R1 1 TVASDLQK 8 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 T(0.048)VAS(0.952)DLQK 121.36 0.006932600000000001 62111000.0 3828.4 5508.4 5353.0 6179.8 5024.0 5072.8 5417.0 5221.2 2987.8 4657.6 True False 3917.594271230366 4863.473967214313 4626.092001924252 5100.613939213111 4569.580087059245 5021.772237733877 5008.391328748283 5082.716815152204 5070.078379721965 5255.448328865895 0.7454348375404477 0.9254156187782046 0.8802468814154519 0.9705383099663741 0.8694938663863416 0.9555364116418885 0.9529903093594061 0.9671328680438257 0.9647280426817683 1.0 12.359598126726272 -3.9485004936744983 1.0477973646216079 0.9483227047472771 2.9834129769457834e-40 0.7060487602920997 0.0383610059153365 4.81392349130763 1.1917942652150795 0.011608807549492789 7.744228573344383 0.00011258991890535964 3.9485004936744983 -0.9483227047472771 TVAS(ph)DLQK ddPTM_A459_Selumetinib_30min_R2 1 TVASDLQK 8 0 Q7L8J4;Q7L8J4-2 Q7L8J4 SH3BP5L SH3 domain-binding protein 5-like 1 T(0.364)VAS(0.636)DLQK 122.69 0.006279 40746000.0 256040.0 252060.0 214620.0 228750.0 243420.0 165010.0 210630.0 191610.0 162100.0 224440.0 True False 241810.3218093291 271392.19149935734 200811.58286058737 197593.8553842403 212839.40339758917 187738.62968835904 220424.712355427 192167.5533772571 194524.52945242735 217959.83403484765 1.109426068707082 1.2451477250435365 0.9213238014692258 0.9065608636527444 0.9765074576243262 0.8613450754341425 1.011308864917677 0.8816649830378067 0.892478792314214 1.0 17.733702771926573 -5.270186647173661 24.799939128803178 0.9282484462279581 1.1772868986692446 0.7511020825111636 0.05659531213185018 213.85651982666337 606319.7199048352 0.013741649160392874 0.029342463585492713 5.368010452668623e-06 5.270186647173661 0.24903845244128653 TVAT(ph)PLNQVANPNSAIFGGAR ddPTM_A459_Selumetinib_30min_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 1 TVAT(1)PLNQVANPNSAIFGGAR 150.13 1.6446e-06 0.0 878.35 822.11 763.85 1022.8 836.82 875.25 897.8 857.05 383.23 548.51 True False 898.8138460284167 725.8569790114303 660.1233655277111 844.1871803338562 761.1297787525709 866.4457796634164 830.0782231770731 834.3182499092537 650.3133199882348 618.9166014398472 1.452237416054791 1.172786409869758 1.0665788637629052 1.363975660646264 1.2297776097488402 1.3999394710817539 1.3411794436374458 1.348030167502853 1.0507285124931958 1.0 9.273601210207458 -10.373353971167429 5.555542247143374 0.9999998888321782 1.2705284791374307 0.2769229311907596 0.13062059761404882 1.7883950709104865e-07 3.676609552550618e-08 0.12575555528780025 0.030500189932394284 4.232978170623477e-11 10.373353971167429 0.27052859030525256 TVAT(ph)PLNQVANPNSAIFGGAR ddPTM_A459_Selumetinib_30min_R2 2 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 1 TVAT(1)PLNQVANPNSAIFGGAR;T(0.007)VAT(0.993)PLNQVANPNSAIFGGAR 199.75 2.7153999999999997e-16 17050800.0 47433.0 44226.0 45882.0 62706.0 50772.0 51229.0 54321.0 47654.0 55009.0 48070.0 True False 44796.863749343516 47617.9919909965 42930.00207254442 54165.33462611647 44393.56745256104 58285.32973943969 56847.0341350195 47792.665250455604 66012.3370798801 46682.0941991407 0.9596155553400197 1.0200483249072623 0.9196245971615954 1.160302157719255 0.9509763478729755 1.2485585905979464 1.2177481561241936 1.0237900863354015 1.414082598742865 1.0 15.51058166259439 -6.759951291245498 24.9999480534551 1.1846297900298732 1.0073153267943555 0.3401638783018991 0.12429643499764342 45.94614759004971 771902.1510402891 0.03976017507498803 0.03774486334666918 1.7379957445598054e-07 6.759951291245498 -0.1773144632355177 TVAT(ph)PLNQVANPNSAIFGGARPR ddPTM_A459_Selumetinib_30min_R2 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 1 T(0.212)VAT(0.788)PLNQVANPNSAIFGGARPR 96.455 9.927e-05 15133000.0 33805.0 40714.0 39251.0 35530.0 33614.0 37499.0 32326.0 34456.0 35438.0 32898.0 True False 31926.25343213705 43836.632883856364 36725.63339325755 30690.75270733133 29391.108807027238 42664.14686797029 33829.22305275381 34556.261255502126 42526.59022045108 31948.149260730825 0.9993146448510967 1.3721180693786952 1.1495386819917919 0.9606425854863202 0.919962798694991 1.335418415626694 1.0588789596752985 1.081635777192799 1.3311127938394471 1.0 14.963444738587087 -6.76062588569264 24.999982594272517 1.1601032511417562 1.093723908946187 0.060917419052786914 0.15474221865737595 91.49802189486697 2811914.4812536407 0.05448248448827745 0.051486744420381855 1.7352981920586085e-07 6.76062588569264 -0.06637934219556918 TVCGSPLAAQPSPSAELPQAAPPPPGS(ph)PSLPGR ddPTM_A459_Selumetinib_30min_R2 1 TVCGSPLAAQPSPSAELPQAAPPPPGSPSLPGR 33 0 W0Z7M9;A0A499FIJ6;B0QY83;Q969V6;A0A087WU73 W0Z7M9 mkl1;MKL1 MKL/myocardin-like protein 1 1 TVCGSPLAAQPSPSAELPQAAPPPPGS(0.735)PS(0.265)LPGR 98.762 3.8825e-11 2824600.0 15064.0 11740.0 15514.0 16856.0 15541.0 11881.0 14698.0 17673.0 14604.0 15477.0 True False 14226.80318596991 12640.420249950228 14515.846130366032 14560.183721778123 13588.600641697223 13517.49990502026 15381.486123534474 17724.425504077353 17525.208069853492 15030.138795924713 0.9465516838625189 0.8410048916765536 0.9657825737645133 0.9687324860716513 0.9040901635174288 0.8993596192661514 1.02337618649969 1.1792589373082285 1.166004406732777 1.0 13.875570711442963 -7.511803500208252 3.7916944750819805 1.1282556287857395 0.9217831684663769 0.6962246622963899 0.057471112152074615 0.11552507770464644 3.673620495775272 0.027262260520242027 0.016133734751764935 3.077488932701714e-08 7.511803500208252 -0.20647246031936262 TVCSTY(ph)LQSR ddPTM_A459_Selumetinib_30min_R1 2 TVCSTYLQSR 10 0 Q9H422-2;Q9H422 Q9H422-2 HIPK3 Homeodomain-interacting protein kinase 3 1 TVCS(0.104)T(0.186)Y(0.708)LQS(0.002)R;TVCST(0.11)Y(0.889)LQSR 191.45 0.0024847 19257900.0 1622.9 1655.71 1886.69 1978.2400000000002 1816.39 1769.65 1523.6100000000001 1448.75 867.47 1490.52 True False 1660.7104123863119 1461.8587034813045 1630.487860846341 1632.7775201639124 1652.0978452097017 1751.8489277136403 1408.6828710345512 1410.324443796781 1472.0332324979624 1681.8427608942782 0.9874350034382943 0.8692005801446012 0.9694651002804623 0.9708264994378687 0.9823140923894929 1.0416246800516227 0.8375829796868282 0.8385590357132292 0.8752502116875928 1.0 10.71582711589011 -7.277092355566884 24.977210350950063 0.8743946425905516 0.9661092824729731 0.3105540118682695 0.058533325007923985 924.3034843123481 1474891.124769855 0.024360125929192428 0.01648446959893156 5.2833288637829084e-08 7.277092355566884 0.09171463988242157 TVCSTY(ph)LQSR ddPTM_A459_Selumetinib_30min_R2 2 TVCSTYLQSR 10 0 Q9H422-2;Q9H422 Q9H422-2 HIPK3 Homeodomain-interacting protein kinase 3 1 TVCS(0.126)T(0.198)Y(0.675)LQSR;TVCS(0.094)T(0.184)Y(0.722)LQSR 159.34 0.006438200000000001 8447100.0 17752.6 19990.8 21225.1 25762.1 24899.0 16425.3 15504.8 16870.7 16224.1 19814.5 True False 16765.98156128846 21524.030079446773 19859.500174141558 22253.25753789868 21770.96502011577 18687.7359809721 16225.80392217835 16919.79094390527 19469.373339229656 19242.40390074627 0.8713038998541254 1.1185728243970607 1.0320696040150865 1.1564697245044129 1.1314056773993522 0.9711747075555014 0.843231646413423 0.879297151810075 1.0117952746265024 1.0 14.232001421851093 -6.950637565567231 6.4172974236941975 0.9211685157239289 1.0679213295439631 0.32437267190562435 0.08756650545210638 0.20856980974435843 19.676367994539838 0.031196743382242608 0.02732350369914026 1.120372484742352e-07 6.950637565567231 0.14675281382003424 TVDGS(ph)PMMK ddPTM_A459_Selumetinib_30min_R2 1 TVDGSPMMK 9 0 A0A087WWY4;A0A087WTK8;O75781-2;O75781 A0A087WWY4 PALM Paralemmin-1 1 TVDGS(1)PMMK 99.752 0.018527 3133600.0 24076.0 7397.6 14093.0 13291.0 11278.0 6698.0 22689.0 13339.0 11601.0 10345.0 True False 22737.95230386427 7964.972132966935 13186.271723298214 11480.74287174615 9861.156813400763 7620.5887016097795 23744.08345740057 13377.81428160967 13921.524159022894 10046.312970462051 2.263313154857697 0.7928254033480114 1.3125483709365018 1.1427817255446429 0.9815697403011752 0.7585458191493404 2.3634624490808123 1.3316143266632072 1.3857346670320398 1.0 13.294378504316505 TVDLGIS(ph)DLEDDC ddPTM_A459_Selumetinib_30min_R1 1 TVDLGISDLEDDC 13 0 F5H5U2;Q8NHQ9-2;Q8NHQ9 F5H5U2 DDX55 ATP-dependent RNA helicase DDX55 1 TVDLGIS(1)DLEDDC 138.45 0.00098729 691950.0 432.59 337.9 399.26 518.4 262.92 454.68 538.77 251.47 0.0 334.41 True False 442.6685053263876 298.33851091455193 345.04268497819476 427.87117157320233 239.13893242229625 450.106332016409 498.1301451337844 244.80019871032036 0.0 377.33478092924327 1.17314524846146 0.7906467306826283 0.9144205687280552 1.1339298500909607 0.6337579902742623 1.1928567276728503 1.320127828945597 0.6487612886028246 0.0 1.0 8.559701276833609 -7.984938636680014 15.538499604139156 0.44146074217225895 1.003984624745499 0.3511614612669366 0.2964079165127593 2.5653086466578268 2646.420218509544 0.15527813891773357 0.0741845553127348 1.0352884366651532e-08 7.984938636680014 0.5625238825732402 TVDLGIS(ph)DLEDDC ddPTM_A459_Selumetinib_30min_R2 2 TVDLGISDLEDDC 13 0 F5H5U2;Q8NHQ9-2;Q8NHQ9 F5H5U2 DDX55 ATP-dependent RNA helicase DDX55 1 TVDLGIS(1)DLEDDC;TVDLGIS(1)DLEDDC 122.7 0.0019417 0.0 8804.2 7503.3 10571.9 8903.7 9699.1 7917.099999999999 5245.5 10516.5 7249.0 10547.6 True False 8314.897810005064 8078.778983087866 9891.71546381441 7691.00070026079 8480.612346945858 9007.608660721817 5489.42614376106 10547.1012738997 8699.002553983015 10243.06338204403 0.8117588947639416 0.7887073116475947 0.9656989413103183 0.7508496641486202 0.8279371151614927 0.8793862075003899 0.5359164479430987 1.0296823206608918 0.8492579055238751 1.0 13.322359624686767 TVDSQGPT(ph)PVCTPT(ph)FLER ddPTM_A459_Selumetinib_30min_R2 2 TVDSQGPTPVCTPTFLER 18 0 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 2 T(0.002)VDS(0.001)QGPT(0.997)PVCT(0.221)PT(0.779)FLER;TVDS(0.001)QGPT(0.999)PVCT(0.339)PT(0.661)FLER 187.73 1.6432e-09 6292600.0 30041.9 33806.1 33223.3 35853.0 39168.0 35724.0 33502.7 27630.9 28308.5 34847.5 True False 28372.291465254217 36398.91916625577 31085.749048793976 30969.759550125265 34247.36567363725 40644.65672981601 35060.64193434064 27711.301344458247 33970.99100557706 33841.36213032155 0.8383909417119149 1.0755748845476487 0.918572631003568 0.9151451833074015 1.0119972577271625 1.2010348925464431 1.0360292768158592 0.8188589229281991 1.0038304863367 1.0 15.046500018311997 -4.741376938343381 24.5413099333669 0.9951490156968341 0.8383902516420865 0.19498273376755304 0.09708451869219785 2190.124662295604 2678886.6163586993 0.025876755615959635 1.007461520110628 1.813940601147189e-05 4.741376938343381 -0.15675876405474765 TVDSQGPTPVCT(ph)PTFLER ddPTM_A459_Selumetinib_30min_R1 4 TVDSQGPTPVCTPTFLER 18 0 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 T(0.002)VDS(0.012)QGPT(0.393)PVCT(0.583)PT(0.009)FLER;TVDS(0.132)QGPT(0.172)PVCT(0.684)PT(0.012)FLER;TVDSQGPT(0.144)PVCT(0.844)PT(0.012)FLER;TVDSQGPT(0.08)PVCT(0.906)PT(0.014)FLER 185.71 4.1672e-10 35452500.0 7348.7 9615.4 8539.6 8712.0 9232.9 7949.8 7407.1 7249.5 3786.91 6757.5 True False 7519.910411918967 8489.62449792181 7379.969224665108 7190.612744494093 8397.785825200892 7869.832229840876 6848.376483509581 7057.219710305273 6426.109685036783 7624.890948624033 0.9862318638505891 1.1134093005558099 0.9678786587756875 0.9430446668606706 1.1013647122017312 1.03212390614728 0.8981605808730183 0.9255502482404421 0.8427805365788767 1.0 12.896500988912926 -7.259762717345653 24.76338753253647 0.9104186916741793 1.0253571243658517 0.4188927754768018 0.06177781697199479 126.11546695337803 1862674.822762047 0.024358821153216654 0.017865634127002247 5.4984120497186446e-08 7.259762717345653 0.11493843269167237 TVDSQGPTPVCT(ph)PTFLER ddPTM_A459_Selumetinib_30min_R2 1 TVDSQGPTPVCTPTFLER 18 0 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 TVDSQGPT(0.049)PVCT(0.907)PT(0.044)FLER 145.99 0.00059812 18374000.0 45972.0 48388.0 56638.0 54898.0 60033.0 40355.0 45437.0 42783.0 47357.0 52938.0 True False 43417.06028049709 52099.20400805725 52993.97274279178 47420.79769566773 52491.11783817058 45913.5349437836 47549.91053170743 42907.491446893095 56829.72326513633 51409.54239055777 0.8445331014747831 1.0134150506974002 1.0308197715551932 0.9224123672491075 1.0210384181091536 0.8930936322089572 0.924923823878284 0.8346211510875806 1.1054314164752042 1.0 15.64974854989851 -6.766403234183738 24.999851437608942 0.9396097042318127 0.9701835149145656 0.0 0.08411177235464966 575.2884115769481 2897350.553318635 0.02824281776068473 0.02567932332913542 1.7123666692315214e-07 6.766403234183738 0.03057381068275289 TVDSQGPTPVCTPT(ph)FLER ddPTM_A459_Selumetinib_30min_R2 1 TVDSQGPTPVCTPTFLER 18 0 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 TVDSQGPT(0.193)PVCT(0.186)PT(0.621)FLER 215.64 1.4269e-12 15647000.0 20627.0 24074.0 19567.0 21566.0 29000.0 21803.0 20878.0 23522.0 21517.0 25078.0 True False 19480.633916423347 25920.398389889448 18308.080522938773 18628.673596574936 25356.760736710607 24806.165342071967 21848.86836897216 23590.445125723283 25821.001235212094 24353.932979530906 0.7998968352584575 1.0643208393352783 0.7517504683258521 0.7649143820931116 1.0411772405722952 1.018569171678396 0.8971392171989545 0.9686503262348088 1.0602394798784343 1.0 14.571867155219644 -6.271871333467123 24.990237697770407 0.9920842524275766 0.8541942037912177 0.399745842341127 0.09107694494563585 840.1089023663066 2012516.606193211 0.029123112761681252 0.03336869542813913 5.347227559118978e-07 6.271871333467123 -0.1378900486363589 TVDVPASLPT(ph)PPHNNQEELR ddPTM_A459_Selumetinib_30min_R1 1 TVDVPASLPTPPHNNQEELR 20 0 Q8NEZ4;Q8NEZ4-3;H7BY37;Q8NEZ4-2;H0Y765;H7C2V8 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 1 TVDVPAS(0.003)LPT(0.997)PPHNNQEELR 107.17 0.00061603 3708700.0 1507.0 1758.9 1618.5 1884.2 1805.3 1465.0 1781.8 1637.0 774.84 1267.8 True False 1542.1101678884543 1552.9671703095744 1398.7165897841205 1555.159840814482 1642.0109337516024 1450.2634301135727 1647.3973914645896 1593.5814422746023 1314.8468879254858 1430.5344794177656 1.0779958051176093 1.085585277847787 0.9777580407243346 1.087118040976852 1.1478303790481923 1.0137913143511486 1.151595725350911 1.1139762551708627 0.9191298125583347 1.0 10.482338555259604 -8.259296237877875 24.990914049685124 0.9595649015547566 1.0810210442486192 0.4519902042387014 0.053898571135312844 163.27021408310267 1903931.6599238205 0.040947062977152 0.013786309000347233 5.504321114686145e-09 8.259296237877875 0.12145614269386262 TVDVPASLPT(ph)PPHNNQEELR ddPTM_A459_Selumetinib_30min_R2 2 TVDVPASLPTPPHNNQEELR 20 0 Q8NEZ4;Q8NEZ4-3;H7BY37;Q8NEZ4-2;H0Y765;H7C2V8 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 1 TVDVPASLPT(1)PPHNNQEELR;TVDVPASLPT(1)PPHNNQEELR 114.39 0.00037991 12173900.0 69150.0 67159.0 83874.0 76768.0 80684.0 57635.0 64034.0 65291.0 52670.0 61525.0 True False 65306.91982938253 72309.87934977919 78477.63815510635 66312.06596781337 70547.75459588811 65573.6980915615 67011.70788096373 65480.9860004931 63205.47172275973 59748.61338885233 1.0930282081084621 1.2102352715564524 1.3134637559597058 1.1098511280294518 1.1807429594516856 1.0974932198810825 1.1215608878626548 1.0959415170747762 1.0578567122789893 1.0 15.866617611802017 -7.688791044748896 0.5071059801581529 1.0035828969156053 1.200135263265466 0.5057480368010565 0.058312399843302574 0.7418320712614186 0.43477287222611566 0.06047634279040102 0.04211086271391765 2.0474294943687297e-08 7.688791044748896 0.19655236634986073 TVEDEDQDS(ph)EEEKDNDSYIK ddPTM_A459_Selumetinib_30min_R1 2 TVEDEDQDSEEEKDNDSYIK 20 1 Q9Y5T5-4;Q9Y5T5-3;Q9Y5T5-2;Q9Y5T5 Q9Y5T5-4 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 TVEDEDQDS(0.993)EEEKDNDS(0.006)Y(0.001)IK;T(0.002)VEDEDQDS(0.619)EEEKDNDS(0.2)Y(0.179)IK 75.564 0.0033152 38176000.0 2827.25 3845.6000000000004 3376.77 3747.7200000000003 2886.4900000000002 3076.6099999999997 2924.3599999999997 3100.31 2136.0 3213.33 True False 2893.1194241291523 3395.355364229064 2918.2231812698956 3093.2510554172864 2625.4074891511996 3045.662096738375 2703.7731707842563 3018.0797075738396 3624.6359927324847 3625.7922059847647 0.7979275313554218 0.9364451053275089 0.8048511926450309 0.853124194572303 0.7240920990501548 0.8399990743295157 0.7457054947388834 0.8323918018777167 0.9996811143092063 1.0 11.82408053131464 -8.247190234423902 5.164140449288055 1.00290589072487 0.8162107086409787 0.6390558754877469 0.05511539741141637 0.1060120943245504 9.042806310209 0.04422400845300408 0.014192650734812061 5.6599131301986224e-09 8.247190234423902 -0.18669518208389135 TVEDEDQDS(ph)EEEKDNDSYIK ddPTM_A459_Selumetinib_30min_R2 4 TVEDEDQDSEEEKDNDSYIK 20 1 Q9Y5T5-4;Q9Y5T5-3;Q9Y5T5-2;Q9Y5T5 Q9Y5T5-4 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 TVEDEDQDS(0.999)EEEKDNDS(0.001)Y(0.001)IK;T(0.001)VEDEDQDS(0.904)EEEKDNDS(0.048)Y(0.048)IK;TVEDEDQDS(1)EEEKDNDSYIK;TVEDEDQDS(1)EEEKDNDSYIK 94.389 0.00061433 98082700.0 140741.0 117695.0 122818.0 113913.0 103328.0 86585.0 119332.0 109571.0 81120.2 98596.0 True False 132919.17865086248 126721.82805092755 114916.02359412765 98397.85288911448 90347.01287595982 98511.29780962708 124881.17445187204 109889.83346954438 97346.5066877658 95749.2772968271 1.3882003332391428 1.3234755564586054 1.2001764069496081 1.0276615726725193 0.9435790580004064 1.028846384962652 1.3042518750792733 1.1476831634862465 1.01668137281065 1.0 16.546973977352387 -5.391765833301669 2.470682113697121 1.0770858641483545 1.3686828049035507 0.5921323492418054 0.09563730161314715 0.23459294684289034 2.734064529672276 0.029684818072102617 0.08088012818622033 4.057272400444916e-06 5.391765833301669 0.29159694075519615 TVEVAEGEAVRT(ph)PQSVTAK ddPTM_A459_Selumetinib_30min_R2 1 TVEVAEGEAVRTPQSVTAK 19 1 E5RJU9;Q86UE4;H0YB56 E5RJU9 MTDH Protein LYRIC 1 TVEVAEGEAVRT(0.983)PQS(0.009)VT(0.008)AK 72.513 0.017511000000000002 6275300.0 35312.0 9272.7 23684.0 31351.0 18433.0 19953.0 42489.0 25133.0 24488.0 21217.0 True False 33349.50040513604 9983.886273570151 22160.197225189466 27080.939716508437 16117.281746889186 22701.344634699883 44464.82269035626 25206.13286900787 29386.284251887995 20604.41008161367 1.618561282416692 0.484550940018383 1.0755074829812332 1.3143273507584714 0.7822248578362081 1.101771152135892 2.158024544950909 1.2233367890255953 1.4262133269280455 1.0 14.330665538411067 -7.029285544965421 24.992873586545254 1.4932754988824293 1.0291947624820865 0.18622469199553837 0.3938280890162189 1004.3717890369009 857148.1971160634 0.14357423943001368 0.11141227086975837 9.347908549335838e-08 7.029285544965421 -0.46408073640034275 TVFAEHISDECK ddPTM_A459_Selumetinib_30min_R2 2 TVFAEHISDECK 12 0 H7C422;H7C3M2;F8WCR1;P39023;B5MCW2;G5E9G0 H7C422;P39023 RPL3 60S ribosomal protein L3 0 ; 143.42 0.0011617 11385600.0 100541.0 91436.0 159463.0 209790.0 240850.0 154380.0 122006.0 138930.0 146354.0 209064.0 False True 94953.33371751198 98448.84718692086 149203.32419018677 181216.2400920644 210592.26977368098 175644.44367789166 127679.52075030252 139334.26329890048 175628.88947242795 203027.77910649328 0.467686412841597 0.48490333500265453 0.7348911801469581 0.8925686962128065 1.0372584022761728 0.8651251786868123 0.6288770990462903 0.686281768495414 0.865048567468721 1.0 17.631317610898087 -5.351082712430253 3.0324433171294167 0.838468780193468 0.4662517275602437 0.6147978295132652 0.11745222011553866 0.1921033231323079 3.3698679095198334 0.035638147179001274 0.09134250627548053 4.45571380173387e-06 5.351082712430253 -0.37221705263322435 TVFPGAVPVLPAS(ph)PPPK ddPTM_A459_Selumetinib_30min_R1 2 TVFPGAVPVLPASPPPK 17 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 TVFPGAVPVLPAS(1)PPPK;TVFPGAVPVLPAS(1)PPPK 144.68 0.0004932 88463000.0 13121.9 23413.7 11791.3 12242.2 13486.0 14662.3 17755.8 16427.3 7951.799999999999 16630.8 True False 13427.614739227285 20672.413119266177 10190.106224974676 10104.329584555277 12266.193681146677 14514.810574303223 16416.46571072341 15991.5946406094 13493.623823506628 18765.525177710184 0.7155469730832098 1.1016165507491902 0.5430227040529914 0.5384517347032348 0.6536557631606571 0.7734827795570577 0.8748204782578106 0.8521794348502606 0.7190645449952259 1.0 14.195797046042697 -7.032156310490882 4.845247819165672 0.8474465953443554 0.7129518676104972 0.1635913108918755 0.15954578735504046 0.4599027178946953 26.9950199539581 0.06510983412769905 0.052099522214260605 9.286320950268537e-08 7.032156310490882 -0.13449472773385818 TVFPGAVPVLPAS(ph)PPPK ddPTM_A459_Selumetinib_30min_R2 4 TVFPGAVPVLPASPPPK 17 0 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 TVFPGAVPVLPAS(1)PPPK;TVFPGAVPVLPAS(1)PPPK;TVFPGAVPVLPAS(1)PPPK;TVFPGAVPVLPAS(1)PPPK 136.35 0.0005142 71139400.0 217255.0 189616.0 209450.0 221593.0 234474.0 205799.0 247044.0 265772.0 227876.0 208008.0 True False 205180.8368406725 204158.93748846342 195974.21503191703 191411.65113075386 205017.27989584414 234145.94419268306 258532.0355083992 266545.3525190771 273457.5673874234 202002.26857031113 1.0157353097708157 1.0106764589002704 0.9701584859365284 0.9475717895917046 1.0149256310182653 1.1591253199772042 1.2798471885399232 1.3195166292219158 1.3537351304163239 1.0 17.62401196957606 -6.8922176710280985 2.5336206115340882 1.26372480572874 0.9856617729827134 0.6153196506032419 0.09205953324577938 0.16823489822808066 2.1939737656841576 0.034968289504553135 0.02990421487506474 1.2816880318299674e-07 6.8922176710280985 -0.2780630327460266 TVFPGAVPVLPAS(ph)PPPKDSLR ddPTM_A459_Selumetinib_30min_R1 2 TVFPGAVPVLPASPPPKDSLR 21 1 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 TVFPGAVPVLPAS(1)PPPKDSLR;TVFPGAVPVLPAS(0.999)PPPKDS(0.001)LR 189.84 8.2803e-17 457400000.0 7942.4 9046.5 11843.2 11763.9 10353.2 7979.5 9526.4 9117.4 4769.3 6450.5 True False 8127.442466779872 7987.331574396253 10234.958490040968 9709.555700752306 9416.754888005924 7899.233474806318 8807.815978251363 8875.576934510978 8093.153764110038 7278.484508190799 1.1166393852502816 1.0973893762372864 1.4061936215599715 1.334007881699235 1.2937796154417633 1.0852854692370317 1.2101167445420185 1.219426506235316 1.1119284179285476 1.0 12.829422375179186 -6.755113609537679 24.99036800557987 1.1443634143784804 1.2545344771979612 0.2501574026793907 0.10483671006441361 267.4050219407593 1056400.6222934648 0.037570337990052584 0.036691328395607584 1.7574638089712417e-07 6.755113609537679 0.11017106281948075 TVFPGAVPVLPAS(ph)PPPKDSLR ddPTM_A459_Selumetinib_30min_R2 2 TVFPGAVPVLPASPPPKDSLR 21 1 M0R165;Q9UBC2-4;Q9UBC2-3;Q9UBC2;Q9UBC2-2;M0R2S2 M0R165 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 TVFPGAVPVLPAS(0.998)PPPKDS(0.002)LR;TVFPGAVPVLPAS(0.996)PPPKDS(0.004)LR 147.91 1.4608e-06 156052000.0 135995.0 131150.0 135154.0 143071.0 135993.0 102739.0 88687.0 100177.0 88276.0 128497.0 True False 128436.94233111899 141208.78328628402 126458.33878454872 123584.48298875913 118908.34354715461 116890.36467821528 92811.12122995668 100468.49848480496 105933.66663752282 124786.95773469895 1.0292497281981985 1.1315988934236092 1.0133938760924293 0.9903637786530839 0.9528907964881838 0.9367194040159863 0.7437565825370636 0.8051201849026899 0.8489161732970618 1.0 16.929107631435635 -6.417350811136745 1.1111450361962563 0.8383802118080568 1.0689937655019528 0.5854357459847022 0.07085621933891273 0.3138423006056698 0.815337333493894 0.03208773809951421 0.040908498809856315 3.825156328814385e-07 6.417350811136745 0.23061355369389602 TVFS(ph)PTLPAAR ddPTM_A459_Selumetinib_30min_R1 3 TVFSPTLPAAR 11 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 T(0.055)VFS(0.733)PT(0.212)LPAAR;T(0.137)VFS(0.798)PT(0.065)LPAAR;T(0.167)VFS(0.662)PT(0.171)LPAAR 193.3 2.0288e-05 592008000.0 10665.3 13019.3 13115.099999999999 14236.3 13784.7 10638.4 12453.1 12603.5 6754.6 10818.900000000001 True False 10913.780738938778 11494.994303491634 11334.141456087567 11750.197453448256 12537.876318886452 10531.387354894354 11513.752640951674 12269.21423806229 11462.062863535039 12207.61120001015 0.8940144439503205 0.9416251971951791 0.9284487579419424 0.9625304460416045 1.027054033214625 0.862690266125579 0.9431618071963254 1.0050462811309135 0.9389275817963066 1.0 13.575493299197774 -1.5228787453354924 0.07182545538413262 1.0440702739435432 0.7269062901914498 0.18299258652588368 0.04342836857374715 469.90370938566093 2.4963237480584533 1.8763329568882785 15.008740813899037 0.02999999999619004 1.5228787453354924 -0.3171639837520934 TVFS(ph)PTLPAAR ddPTM_A459_Selumetinib_30min_R2 2 TVFSPTLPAAR 11 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 T(0.068)VFS(0.78)PT(0.152)LPAAR;T(0.295)VFS(0.561)PT(0.144)LPAAR 178.53 5.8569e-05 260192000.0 224011.0 272255.0 256374.0 246529.0 247476.0 193166.0 243547.0 274539.0 171171.0 149175.0 True False 211561.36540708315 293136.08306219784 239879.17595890517 212951.32491375445 216385.85241648927 219772.86311363906 254872.4180792249 275337.8630376219 205409.9829173435 144867.93014680297 1.4603740468487119 2.0234711903811027 1.655847334298363 1.4699687135583333 1.4936767039966201 1.5170566935755252 1.759343270943045 1.9006129428273482 1.417912043812525 1.0 17.144378730898758 -8.537444466179219 16.432471340745327 0.9999999916117406 1.6587181017812318 0.5603347469359866 0.17999025251439837 14.316964611840465 16153.218203929722 0.1807458968714011 0.04666862527245627 2.901052136423473e-09 8.537444466179219 0.6587181101694912 TVFSNGYSSPSMRPDVS(ph)SPPSSSSTATTGPPPK ddPTM_A459_Selumetinib_30min_R2 2 TVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPK 33 1 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;P04150-12;P04150-13;P04150-11;P04150-14;P04150-15;P04150-16 P04150-3 NR3C1 Glucocorticoid receptor 1 TVFS(0.001)NGY(0.002)S(0.005)S(0.005)PS(0.004)MRPDVS(0.484)S(0.484)PPS(0.004)S(0.002)S(0.002)S(0.002)T(0.002)AT(0.001)TGPPPK;TVFSNGYSSPSMRPDVS(0.496)S(0.496)PPS(0.005)S(0.001)S(0.001)S(0.001)T(0.001)ATTGPPPK 82.508 1.3024e-06 13247400.0 30386.8 26567.0 39876.0 48984.0 40939.0 31031.5 32634.9 40357.0 31119.0 37047.0 True False 28698.023303998278 28604.603473630996 37310.42157370609 42312.294697886784 35795.8768206964 35305.80744908984 34152.48751482757 40474.43218853898 37343.66953750826 35977.35685033425 0.7976690289779211 0.7950724004719442 1.0370528810361859 1.1760812467104205 0.9949557153297058 0.981334109561243 0.9492772817331153 1.1249973797939787 1.0379770168458422 1.0 15.13480157950777 -5.263179438979456 9.341995846543327 1.0404846045267455 0.7960962682843 0.6939335584785031 0.06409127427259548 0.0529489733461698 95.69910290421775 0.017555725354311925 0.04060972797602613 5.45532414972564e-06 5.263179438979456 -0.2443883362424455 TVFSPT(ph)LPAAR ddPTM_A459_Selumetinib_30min_R1 1 TVFSPTLPAAR 11 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 T(0.074)VFS(0.462)PT(0.464)LPAAR 158.08 0.0013298 65935000.0 4043.3 4186.9 4739.0 5337.4 4869.4 3796.8 4484.4 4427.8 2107.4 3460.8 True False 4137.501023107758 3696.695801562997 4095.4698294636687 4405.323285406655 4428.963629762395 3758.607639218576 4146.13809758885 4310.360360478611 3576.103881593836 3905.0273910466963 1.0595318825660656 0.9466504153181219 1.0487685281935824 1.1281158476652478 1.1341696705935944 0.9625048079908924 1.0617436658946269 1.103797727606533 0.9157692183652786 1.0 11.931116952565485 -9.70809073763133 9.27475953855153 1.000002957330919 1.0432031163483915 0.02559790730986733 0.07202234837114148 0.0 0.0 0.07020658525853571 0.017027598037345562 1.958435452650759e-10 9.70809073763133 0.04320015901747243 TVFSPT(ph)LPAAR ddPTM_A459_Selumetinib_30min_R2 2 TVFSPTLPAAR 11 0 C9J6P4;Q7Z2W4-3;Q7Z2W4-2;Q7Z2W4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 T(0.024)VFS(0.283)PT(0.693)LPAAR;T(0.123)VFS(0.064)PT(0.813)LPAAR 158.3 0.0013364000000000002 43041000.0 113974.0 103303.0 112936.0 118963.0 122986.0 85586.0 98462.0 102103.0 77499.0 100395.0 True False 107639.78135407162 111226.00792850187 105669.82071541932 102760.03417737872 107535.39917121 97374.69462764614 103040.67809875155 102400.10282593835 93000.96550298364 97496.33549246372 1.1040392524536675 1.1408224459584886 1.0838337685377661 1.0539886823266489 1.1029686257236024 0.9987523544941134 1.0568671897080315 1.0502969399691302 0.9538919081750763 1.0 16.573060374142948 -6.301781332896377 0.3786613071171484 0.9876987000374133 1.1501808888558094 0.6329245251831801 0.032817069745173885 1.3368912486457492 0.33439063547926795 0.03346010057495766 0.088866098922904 4.991357388536267e-07 6.301781332896377 0.16248218881839604 TVGGCGALPHGAS(ph)CPYSQERPGAIGLDGCYSE ddPTM_A459_Selumetinib_30min_R2 1 TVGGCGALPHGASCPYSQERPGAIGLDGCYSE 32 1 Q8NB46 Q8NB46 ANKRD52 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 1 TVGGCGALPHGAS(0.812)CPY(0.148)S(0.03)QERPGAIGLDGCY(0.007)S(0.004)E 60.218 0.00054039 7415100.0 18090.0 15057.0 19487.0 27488.0 27833.0 16398.0 16386.0 17362.0 18552.0 22609.0 True False 17084.63022000768 16211.823484114202 18233.227635841373 23744.086980555116 24336.36970982298 18656.67565377682 17147.981468243015 17412.520545566163 22262.91838619022 21956.219424763305 0.7781225851996538 0.7383704439494583 0.8304356630393774 1.081428752427905 1.1084043768653187 0.84972167989608 0.781007929302377 0.7930564096079066 1.013968659881446 1.0 14.422342041966726 -5.5312241131694 24.54237499449882 0.9356468741459539 0.7647856144849137 0.34256401064480424 0.10671324031217853 189.67393154677276 557798.310520683 0.032678200362411654 0.0567293229492525 2.9429025874877703e-06 5.5312241131694 -0.17086125966104027 TVGGCGALPHGASCPYSQERPGAIGLDGCYS(ph)E ddPTM_A459_Selumetinib_30min_R1 2 TVGGCGALPHGASCPYSQERPGAIGLDGCYSE 32 1 Q8NB46 Q8NB46 ANKRD52 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C 1 TVGGCGALPHGASCPYSQERPGAIGLDGCY(0.01)S(0.99)E;TVGGCGALPHGASCPYSQERPGAIGLDGCY(0.017)S(0.983)E 100.23 1.2908000000000002e-06 4119100.0 1725.79 1589.19 1934.68 2508.29 2393.2 1584.06 1660.34 1837.1 803.47 1075.5700000000002 True False 1765.9975491972234 1403.1268960056123 1671.9610824365423 2070.264237934698 2176.735482553777 1568.1257946114026 1535.0992170525965 1788.3741402582004 1363.4299068730186 1213.6298864390012 1.4551368328436307 1.1561406913953214 1.3776531882733736 1.7058448057910054 1.7935743894217149 1.292095565652683 1.264882510068075 1.4735745718207367 1.1234313872028616 1.0 10.24511280311712 -8.402014067738772 1.045556114028141 0.9918710724529926 1.4581158611108254 0.39692365140094565 0.1854806561294079 0.5980755453645678 1.4174251129581923 0.19494151165720638 0.06483408181033477 3.962651981596301e-09 8.402014067738772 0.4662447886578328 TVGT(ph)PIASVPGSTNTGTVPGSEK ddPTM_A459_Selumetinib_30min_R2 1 TVGTPIASVPGSTNTGTVPGSEK 23 0 A0A087WW66;Q99460-2;Q99460;H7BZR6 A0A087WW66 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 T(0.443)VGT(0.551)PIAS(0.006)VPGSTNTGTVPGSEK 135.34 7.6422e-06 7076300.0 57494.0 46730.0 62895.0 64922.0 69352.0 55327.0 71621.0 77539.0 62582.0 50266.0 True False 54298.71364671759 50314.04073936753 58848.40417489831 56079.51160330328 60639.38174525353 62947.79204149958 74951.51841431907 77764.62565272761 75100.1486871796 48814.68997324751 1.1123437161329008 1.0307151549449916 1.205547022979142 1.1488244959465521 1.2422363386613016 1.2895255931359517 1.5354295695700544 1.5930578621997986 1.538474355329054 1.0 15.575027747877998 -6.785842811231821 1.6688043724669521 1.4621295665078413 1.1233436681892173 0.3677975735239588 0.16331730046735904 0.32933164219857847 1.8991429169715466 0.06817669852402465 0.06092775336977837 1.6374090588667288e-07 6.785842811231821 -0.33878589831862405 TVHPNS(ph)PGIPYR ddPTM_A459_Selumetinib_30min_R2 1 TVHPNSPGIPYR 12 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;F8VWY3;C9J102;C9JNI4 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.071)VHPNS(0.929)PGIPYR 118.2 0.0030293000000000004 4856100.0 31699.0 31713.0 34688.0 30767.0 33752.0 26381.0 30885.0 21211.0 21660.0 32240.0 True False 29937.296481151076 34145.28512663304 32456.211845438753 26576.481523964616 29511.772013291586 30014.74328712564 32321.21369746646 21272.72049832991 25992.605230965943 31309.147430420144 0.9561837015103078 1.0905849545253758 1.0366367183126843 0.8488407927116776 0.942592642577606 0.9586573174446502 1.0323249385597446 0.6794410657653748 0.8301920481460119 1.0 14.934296602984462 -6.236701228707841 0.6176673872175418 0.8616323634651173 1.0412943663899317 0.17778415476344644 0.10455455964756613 1.5262913305284582 1.2097952712827869 0.07564173025893706 0.1523607557641573 5.798274494129401e-07 6.236701228707841 0.17966200292481438 TVIESSPES(ph)PVTITEPYR ddPTM_A459_Selumetinib_30min_R1 2 TVIESSPESPVTITEPYR 18 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 1 TVIES(0.01)S(0.057)PES(0.891)PVT(0.04)IT(0.001)EPYR;TVIESS(0.006)PES(0.965)PVT(0.029)ITEPYR 181.72 1.049e-09 11604700.0 2003.9699999999998 2544.0 2427.2 2586.9 2387.9 1932.63 2197.4 1884.2600000000002 1210.6999999999998 1485.85 True False 2050.6586019531705 2246.1472973264854 2097.5995716552484 2135.146477127156 2171.914866617987 1913.1894968876406 2031.6483488631104 1834.2833038609317 2054.469473970606 1676.5733209046257 1.2231249157935427 1.3397250626143422 1.251123076754824 1.2735181041620647 1.295448782070617 1.1411308250183443 1.2117861614110008 1.0940668570767969 1.2253979282350023 1.0 10.711299861973595 -8.592112895154639 0.24282233620980093 0.9434685964564928 1.3276309511745201 0.6637108935371161 0.05572882283747005 1.7388473961024826 0.3317181075303488 0.23671521192336234 0.13578593913155912 2.557920867152891e-09 8.592112895154639 0.3841623547180273 TVIIEQSWGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;C9JL19;C9JCQ4;C9JL25;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 TVIIEQS(0.029)WGS(0.971)PK 183.28 0.0001043 128200000.0 6904.3 11044.0 10669.0 12164.0 5976.9 9247.3 7725.2 7825.4 4742.1 6937.9 True False 7065.156756570839 9750.963345783686 9220.208400622047 10039.785746559479 5436.290450307397 9154.28055787661 7142.481944405802 7617.844971518441 8046.997350719428 7828.447045868832 0.9024978664573339 1.2455808014859588 1.1777825597591114 1.2824747600301643 0.694427696636997 1.169360986187859 0.9123753284088417 0.973097847744716 1.0279174533046025 1.0 12.934510428521873 -6.223277364601615 24.999461208509317 0.9693183242995775 1.16059792626346 0.2869391098228743 0.1456712278365844 708.9257275839038 464408.2432910366 0.04100007218824229 0.05292984068061856 5.980295381601978e-07 6.223277364601615 0.1912796019638825 TVIIEQSWGSPK ddPTM_A459_Selumetinib_30min_R2 2 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;C9JL19;C9JCQ4;C9JL25;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 ; 197.3 0.0015316 4936600.0 47847.0 37568.0 42699.0 47343.0 38284.0 32862.0 52191.0 38447.0 38073.0 40781.0 False True 45187.85528671683 40449.34479984075 39951.79282715607 40894.80172876971 33474.42165669752 37388.44220846529 54617.984914504515 38558.874404756534 45688.66384850258 39603.5465682371 1.1410052685270988 1.02135662850665 1.008793309920336 1.032604533493175 0.8452379788517408 0.9440680304741098 1.3791185297104003 0.973621752241795 1.1536508168474457 1.0 15.273342011553828 TVKEPEGPPPS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 TVKEPEGPPPSPGK 14 1 P58012 P58012 FOXL2 Forkhead box protein L2 1 TVKEPEGPPPS(1)PGK 66.12 0.038534 5923000.0 2399.1 3689.5 3609.3 3765.6 3188.5 3304.1 3319.6 2926.3 1980.9 2706.2 True False 2454.994362164028 3257.5316247979827 3119.176884465756 3108.008649066454 2900.100737975397 3270.863753882768 3069.199899374707 2848.685018037978 3361.442620788283 3053.567130620251 0.8039758934873527 1.0667954839218816 1.0214862654197414 1.0178288264568607 0.949741929330474 1.0711615674283141 1.0051195104236272 0.9329040090431361 1.1008248638389997 1.0 11.576279846872346 -4.752836120826211 24.984636352762774 1.0154946721481926 0.8039754923473865 0.6273027444017891 0.04954346552225656 210.22141848522895 610455.5032657163 0.011769566783276172 0.13538085141238873 1.766704353287816e-05 4.752836120826211 -0.21151917980080603 TVLEGSTAST(ph)SPADHSALPNQSLTVR ddPTM_A459_Selumetinib_30min_R1 2 TVLEGSTASTSPADHSALPNQSLTVR 26 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 TVLEGS(0.028)T(0.036)AS(0.148)T(0.753)S(0.036)PADHSALPNQSLTVR;TVLEGS(0.012)T(0.036)AS(0.116)T(0.457)S(0.379)PADHSALPNQSLTVR 117.33 1.0530999999999998e-08 31385000.0 2339.54 2209.9 2675.5 2647.5 2738.88 2139.1000000000004 2836.1 2178.7200000000003 1230.5900000000001 2071.89 True False 2394.0467300476153 1951.1638806453636 2312.18179546952 2185.1638247300402 2491.1487875885373 2117.582596147403 2622.17069364279 2120.9332681200503 2088.2213512624844 2337.837263417632 1.0240433615759088 0.8346020962096398 0.9890259821119426 0.9346945824345353 1.065578355931748 0.9057869977877571 1.1216224220027604 0.9072202335501768 0.8932278494910121 1.0 11.190958792191347 TVLEGSTAST(ph)SPADHSALPNQSLTVR ddPTM_A459_Selumetinib_30min_R2 1 TVLEGSTASTSPADHSALPNQSLTVR 26 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 TVLEGS(0.003)T(0.009)AS(0.084)T(0.819)S(0.084)PADHSALPNQSLTVR 107.49 3.9777e-08 14907000.0 3371.3 3555.9 7756.7 11915.0 8559.6 7287.9 5751.7 3300.7 6306.9 9094.1 True False 3183.9366423831893 3828.6260959793904 7257.642366856398 10292.156445478555 7484.266524205105 8291.742072030738 6019.165446777337 3310.3044905396982 7568.456229509655 8831.529703690569 0.3605192700708087 0.43351788698388943 0.8217876868854933 1.165387740379519 0.847448491406595 0.9388794863664149 0.6815541190176844 0.37482798581953136 0.8569813479024938 1.0 13.108447632478054 -5.237876469049154 5.096796226669388 0.8247208809264134 0.3866856479598424 0.4444375737453936 0.19636760994709535 0.1873954435248171 14.375465779420407 0.05594483767204831 0.1461763069773754 5.7826050473754276e-06 5.237876469049154 -0.438035232966571 TVLEGSTASTS(ph)PADHSALPNQSLTVR ddPTM_A459_Selumetinib_30min_R1 1 TVLEGSTASTSPADHSALPNQSLTVR 26 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.001)VLEGS(0.025)T(0.088)AS(0.088)T(0.369)S(0.429)PADHSALPNQSLTVR 81.847 0.0011149 0.0 481.77 622.83 713.09 800.24 587.51 523.84 646.57 665.34 305.09 581.33 True False 492.99430363876616 549.9087740541885 616.2562947229894 660.4931063652383 534.3698242333152 518.5706452086649 597.7987043435065 647.6930218710964 517.7154471080305 655.9493681337196 0.751573715272283 0.8383402755898164 0.9394875956300357 1.0069269648729846 0.8146510236814197 0.7905650502935629 0.9113488531048349 0.9874131348184483 0.7892612940248931 1.0 9.357440649188973 TVLEGSTASTS(ph)PADHSALPNQSLTVR ddPTM_A459_Selumetinib_30min_R2 1 TVLEGSTASTSPADHSALPNQSLTVR 26 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 T(0.026)VLEGS(0.036)T(0.036)AS(0.102)T(0.09)S(0.708)PADHS(0.001)ALPNQSLTVR 66.429 0.0009753 16451000.0 5105.3 2794.9 3662.6 10506.0 8863.7 0.0 4412.9 4262.9 5093.8 5071.5 True False 4821.567864135167 3009.259842980059 3426.9523035373622 9075.06467613912 7750.162763516611 0.0 4618.108593995463 4275.3043332389125 6112.7023326636345 4925.07261766054 0.9789841162637437 0.6110082178665395 0.6958176192669417 1.842625557153687 1.5736139068743351 0.0 0.9376731984490234 0.8680692986958892 1.241139533810007 1.0 12.265929281183666 TVLPT(ph)VPESPEEEVK ddPTM_A459_Selumetinib_30min_R1 1 TVLPTVPESPEEEVK 15 0 O75152;E9PBY7;E9PQ61;A0A1W2PPR9 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 TVLPT(0.646)VPES(0.354)PEEEVK 227.92 2.2977e-13 21015000.0 3591.0 3785.9 3696.3 4321.2 3059.7 3598.9 3721.3 3443.4 2061.2 3051.1 True False 3674.6633131303543 3342.6450679828395 3194.362762322548 3566.5835389701415 2782.95067523391 3562.698333539751 3440.5993449641824 3352.069846260457 3497.7058559083293 3442.738405230748 1.0673664044724482 0.9709262437436922 0.9278552089433142 1.0359728562446768 0.808353800859692 1.0348443344190024 0.9993786747598029 0.9736638256242376 1.0159662002184269 1.0 11.749340847267769 TVLPTVPES(ph)PEEEVK ddPTM_A459_Selumetinib_30min_R1 3 TVLPTVPESPEEEVK 15 0 O75152;E9PBY7;E9PQ61;A0A1W2PPR9 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 TVLPT(0.002)VPES(0.998)PEEEVK;TVLPTVPES(1)PEEEVK;TVLPT(0.016)VPES(0.984)PEEEVK 240.5 4.0399e-20 43039400.0 9185.3 10312.4 10082.7 11009.699999999999 8724.3 8855.3 9479.8 9548.2 5177.9 8272.900000000001 True False 9399.299618517467 9105.019413895308 8713.524720306676 9087.062572664905 7935.188605400269 8766.223721969092 8764.731053769237 9294.95071907536 8786.518121146784 9334.807299870035 1.006908800211476 0.9753837568797027 0.9334445201057326 0.9734601133963869 0.8500645327205358 0.9390899501579578 0.9389300466750143 0.9957303263458657 0.9412640067319992 1.0 13.188404525604048 -10.161340477659614 10.248527170863074 0.9999984510984455 0.9490862178221713 0.11342241262151831 0.041375099076892165 0.0 0.0 0.04149952293233019 0.010065112733102339 6.896988825416029e-11 10.161340477659614 -0.050912233276274255 TVLPTVPES(ph)PEEEVK ddPTM_A459_Selumetinib_30min_R2 2 TVLPTVPESPEEEVK 15 0 O75152;E9PBY7;E9PQ61;A0A1W2PPR9 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 TVLPTVPES(1)PEEEVK;TVLPT(0.007)VPES(0.993)PEEEVK 169.94 5.5927e-05 9976400.0 68572.0 64118.0 69754.0 79923.0 70326.0 58938.0 67313.0 60125.0 50894.0 65340.0 True False 64761.04275546525 69035.64442813538 65266.10358241287 69037.34952513492 61491.01915758307 67056.17451410537 70443.18787817903 60299.953795770416 61074.22209717359 63453.464426291925 1.0206068863378173 1.0879728168085725 1.0285664332516709 1.0879996884225176 0.9690726852118776 1.0567772007468306 1.1101551115464534 0.9503019943980419 0.9625041382589585 1.0 15.953411313894557 -7.781089378432337 24.99994058158002 0.9673022613518043 1.050532365046889 0.4629364381814792 0.03974211831094491 215.94295621657966 274731.9255475271 0.021251240585881834 0.010231045376996234 1.6554292386789424e-08 7.781089378432337 0.08323010369508466 TVMDGGLES(ph)DGPNMTENGLEDESRPQR ddPTM_A459_Selumetinib_30min_R1 1 TVMDGGLESDGPNMTENGLEDESRPQR 27 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 T(0.001)VMDGGLES(0.999)DGPNMTENGLEDESRPQR 121.76 1.4671e-11 9353400.0 946.95 823.85 657.66 932.79 927.95 855.2 986.27 911.03 334.13 832.61 True False 969.0120925560528 727.3932590025258 568.3533842677946 769.8957371368969 844.0170863428793 846.5974644594723 911.8748598494677 886.8665249575024 566.9942061103488 939.4836038081919 1.0314305525164753 0.7742479549978745 0.60496360124219 0.8194882103488857 0.8983840515381647 0.9011306435022324 0.9706128517338544 0.9439936166662127 0.6035168722605065 1.0 9.875724173228438 -6.1492448766114185 5.0540331001655945 0.8880909453393873 0.7879468472751969 0.06632373418286419 0.14035625274654967 0.5867408403128069 22.311772769090556 0.042507223222620114 0.0555275719692904 7.091777858570957e-07 6.1492448766114185 -0.10014409806419033 TVMDGGLES(ph)DGPNMTENGLEDESRPQR ddPTM_A459_Selumetinib_30min_R2 3 TVMDGGLESDGPNMTENGLEDESRPQR 27 1 P51116 P51116 FXR2 Fragile X mental retardation syndrome-related protein 2 1 TVMDGGLES(0.985)DGPNMT(0.015)ENGLEDESRPQR;TVMDGGLES(0.999)DGPNMTENGLEDESRPQR;T(0.001)VMDGGLES(0.959)DGPNMT(0.041)ENGLEDESRPQR 86.191 3.1256e-05 124475000.0 139814.0 123040.0 150020.0 151958.0 171403.0 142190.0 144989.0 134389.0 124151.0 153803.0 True False 132043.69759978738 132476.77236404433 140367.87652942596 131261.05825782884 149869.822777738 161775.38182769375 151731.2757902531 134780.04974070346 148984.6690687741 149362.30776181468 0.8840496613801324 0.8869491530306468 0.9397811176918077 0.8788097895966394 1.00339787877898 1.0831071389555254 1.0158605478446154 0.9023698934515307 0.9974716600278913 1.0 17.188456598026825 -6.267829423326102 24.37175126751672 1.0003979528896518 0.8996785298910732 0.5703067394818331 0.04376887581687091 302.97517241759095 1155551.554003934 0.01480631781945799 0.017199922925301658 5.397225662687411e-07 6.267829423326102 -0.10071942299857861 TVNS(ph)NCEINNR ddPTM_A459_Selumetinib_30min_R2 1 TVNSNCEINNR 11 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 TVNS(1)NCEINNR 146.67 0.00068001 3241700.0 35773.0 31983.0 28573.0 33214.0 37439.0 26323.0 35470.0 47401.0 27797.0 50325.0 True False 33784.879870665245 34435.993258446186 26734.644287930187 28690.195902654195 32735.578111093397 29948.754313597212 37119.42528247164 47538.92906234199 33357.17671307295 48871.98648994709 0.6912933624585682 0.7046161969603921 0.5470341233915154 0.5870478767740643 0.6698229489367507 0.6128000203093368 0.7595235624421991 0.9727234859201127 0.6825418631169101 1.0 15.576720126265197 -7.484898474830314 4.080525093360692 0.8719225638332714 0.6353011097661001 0.6011097228312787 0.09104866620423861 0.1510579545580872 5.472443819631168 0.04075973123829025 0.025064317304986868 3.27417226370171e-08 7.484898474830314 -0.23662145406717128 TVNVS(ph)SIR ddPTM_A459_Selumetinib_30min_R2 1 TVNVSSIR 8 0 Q92674 Q92674 CENPI Centromere protein I 1 TVNVS(0.774)S(0.226)IR 86.882 0.03325 3975200.0 51039.0 53219.0 53416.0 68921.0 73792.0 59254.0 43802.0 50517.0 43798.0 64530.0 True False 48202.45670530525 57300.72617394394 49979.27271494343 59533.84090464342 64521.58925114991 67415.70064574294 45838.879792016414 50663.99610646043 52558.82381836778 62666.85123092471 0.7691858735279554 0.9143705970289329 0.7975392369846686 0.9500053016109541 1.0295967961337418 1.0757792887553728 0.7314693317381158 0.8084656419031768 0.8387021652753978 1.0 15.935414884600712 -3.902428456693215 1.256467968421431 0.9052795850742401 1.9707501236766984e-15 0.12495012762315627 0.10576246156910221 28.466654590221946 7.346441608526172 0.03379160891486715 56.3798986288387 0.000125190548813525 3.902428456693215 -0.9052795850742381 TVPLFPHPPVPSLSTSES(ph)KPPPQPSPPTSPVR ddPTM_A459_Selumetinib_30min_R1 1 TVPLFPHPPVPSLSTSESKPPPQPSPPTSPVR 32 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 TVPLFPHPPVPS(0.129)LS(0.129)T(0.129)S(0.129)ES(0.147)KPPPQPS(0.113)PPT(0.113)S(0.113)PVR 52.971 0.0018132 16925000.0 1290.9 1388.3 1538.5 1514.5 1795.8 1127.5 1126.1 1291.3 735.09 1173.6 True False 1320.9754583458573 1225.7571905968405 1329.5801503755763 1250.0210056859855 1633.37020707424 1116.1583736880912 1041.1573703716892 1257.0505292664607 1247.3940411506187 1324.2429918320624 0.9975325272579434 0.9256286030262701 1.0040303468294214 0.9439513845994439 1.2334369274739423 0.8428652298502327 0.7862283408661048 0.949259718208784 0.9419676364870734 1.0 10.370952158276896 TVPLFPHPPVPSLSTSESKPPPQPS(ph)PPTSPVR ddPTM_A459_Selumetinib_30min_R1 1 TVPLFPHPPVPSLSTSESKPPPQPSPPTSPVR 32 1 E9PKC0;Q6IQ23;Q6IQ23-2;H0YDE2;Q6IQ23-3;A0A1B0GUM1;A0A1B0GUN0 E9PKC0 PLEKHA7 Pleckstrin homology domain-containing family A member 7 1 TVPLFPHPPVPS(0.029)LS(0.016)T(0.016)S(0.017)ES(0.017)KPPPQPS(0.53)PPT(0.253)S(0.122)PVR 53.56399999999999 0.001218 18911000.0 1537.3 1875.5 2148.3 1844.0 1568.2 1756.8 1734.1 1355.2 674.02 1355.6 True False 1573.1160989349187 1655.9155881037045 1856.5726597672096 1521.9800161670241 1426.3565868881965 1739.1281870467753 1603.29544086808 1319.2556936900078 1143.7627115269422 1529.6044646621885 1.0284463305893525 1.0825776377878262 1.2137599638722496 0.9950154117150487 0.9325002769282619 1.1369790211947766 1.0481764913141556 0.8624815919201464 0.7477506361617092 1.0 10.578942924087501 -7.755309207894292 5.3954103365051616 0.8513765315895665 1.065314371238574 0.4774986522344362 0.09180399525550585 0.13723158439729435 12.203640944706704 0.04845307472026204 0.025122110738960868 1.756672457370389e-08 7.755309207894292 0.21393783964900748 TVPPAVTGITFLS(ph)GGQSEEEASINLNAINK ddPTM_A459_Selumetinib_30min_R1 1 TVPPAVTGITFLSGGQSEEEASINLNAINK 30 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 TVPPAVTGIT(0.001)FLS(0.986)GGQS(0.013)EEEASINLNAINK 119.75 5.809e-16 6059600.0 1351.5 1293.5 2143.4 1925.9 1736.1 1511.8 1437.6 1417.3 1016.1 1395.6 True False 1382.9873204387825 1142.0564186681638 1852.3380528534362 1589.5777186204286 1579.07006153335 1496.5926646045723 1329.1606745816005 1379.7085999607793 1724.2474869922648 1574.738854295183 0.8782328045482665 0.725235435420384 1.1762826882699229 1.0094230635668713 1.0027504288894336 0.9503751434865134 0.8440514888905197 0.8761507320388721 1.0949418580034964 1.0 10.620896884797881 -5.235236280821613 24.997192126340913 0.9837384949635222 0.8017341159420017 0.38168312298469154 0.097277890539521 856.5145047231412 817093.7699404426 0.025743629219034593 0.06806494240814355 5.817866067515279e-06 5.235236280821613 -0.18200437902152045 TVPPAVTGITFLSGGQS(ph)EEEASINLNAINK ddPTM_A459_Selumetinib_30min_R1 1 TVPPAVTGITFLSGGQSEEEASINLNAINK 30 0 P04075;P04075-2;H3BQN4;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 TVPPAVTGIT(0.002)FLS(0.388)GGQS(0.609)EEEASINLNAINK 125.05 5.8624999999999994e-18 6598900.0 952.32 941.84 1213.9 1070.5 1194.6 1009.9 1115.3 1059.4 604.52 958.11 True False 974.5072031078527 831.5689349504626 1049.059047475406 883.5572707737522 1086.54864092376 999.7413229158337 1031.1720230668188 1031.3012705838214 1025.8262876061053 1081.0927512817125 0.9014094322180081 0.7691929614407074 0.9703691438423501 0.817281652962923 1.0050466434407033 0.924750741072465 0.9538238248700595 0.9539433775327235 0.9488790729471779 1.0 10.078274587636475 -6.010038359151456 1.1045258042192343 0.9606405530529807 0.8490485006536027 0.35261113370531016 0.05844467007988128 0.5611777434146628 1.394224117410169 0.02171671595370846 0.04348394671993802 9.77150910084504e-07 6.010038359151456 -0.11159205239937797 TVPS(ph)TPTLVVPHR ddPTM_A459_Selumetinib_30min_R2 2 TVPSTPTLVVPHR 13 0 P12270 P12270 TPR Nucleoprotein TPR 1 T(0.001)VPS(0.5)T(0.5)PTLVVPHR;TVPS(0.657)T(0.343)PTLVVPHR 141.0 0.00056336 20660100.0 60085.0 59884.0 62575.0 75102.0 71688.0 52154.0 72194.0 73630.0 71122.0 90311.0 True False 56745.716239312416 64476.91024259114 58548.99262650864 64872.97804182375 62681.91254114862 59337.74009312573 75551.16404969702 73844.2511098973 85348.38731471653 87703.4867738423 0.6470177905884229 0.7351692916024574 0.6675788475489776 0.7396852785238661 0.7147026286740927 0.6765721897253383 0.8614385451346761 0.8419762295234249 0.973147025896487 1.0 16.420346579703327 -7.796284679857187 0.9894623579212437 1.0007839440318282 0.6941049964535615 0.8913262210359829 0.03966444193429853 0.15763581765819198 0.2801118059803118 0.03351606606507266 0.013480623981716486 1.598509862547784e-08 7.796284679857187 -0.30667894757826675 TVPST(ph)PTLVVPHR ddPTM_A459_Selumetinib_30min_R1 2 TVPSTPTLVVPHR 13 0 P12270 P12270 TPR Nucleoprotein TPR 1 TVPS(0.233)T(0.766)PTLVVPHR;TVPS(0.024)T(0.974)PT(0.001)LVVPHR 141.34 0.0011303 16442500.0 5455.700000000001 8486.9 5793.8 5868.1 6201.0 7059.799999999999 11391.5 11954.9 9761.099999999999 5390.5 True False 5582.807195055766 7493.24980254723 5007.033783065331 4843.346492879453 5640.120644875469 6988.784821785533 10532.22998365073 11637.817217012003 16563.873777463035 6082.423182916437 0.9178590550450466 1.23195140772075 0.8231972081667175 0.7962856820753362 0.9272818538369292 1.1490132487681508 1.7315845456515362 1.9133521077091238 2.723235999755099 1.0 12.570430479632561 -7.285144262792163 2.223041582085973 1.9795914287810175 0.9422690636918911 0.5272750100282063 0.4048346952950308 0.22781819546438278 2.203523358264983 0.19176686828640813 0.12246740327108642 5.186277339239019e-08 7.285144262792163 -1.0373223650891263 TVPST(ph)PTLVVPHR ddPTM_A459_Selumetinib_30min_R2 1 TVPSTPTLVVPHR 13 0 P12270 P12270 TPR Nucleoprotein TPR 1 TVPS(0.031)T(0.968)PTLVVPHR 171.11 0.00028519 12147000.0 24545.0 25583.0 29732.0 32967.0 31932.0 23274.0 31521.0 30724.0 32213.0 41328.0 True False 23180.887161420018 27545.133837689693 27819.075489753974 28476.837728752944 27920.416684298016 26479.78223966348 32986.788957676574 30813.401753367994 38656.50010642222 40134.753256960415 0.5775764214371953 0.686316262151497 0.6931418093352653 0.709530654055144 0.6956668328204032 0.6597718956966852 0.8219008784352201 0.7677486281300147 0.9631677528681001 1.0 15.292564407687133 -8.029714328420384 0.8297135214463892 1.0103095095759622 0.6671707134188946 0.8567836780479166 0.04825876818690528 0.2038512164436163 0.2773594725124497 0.043813451161368734 0.017597255251435195 9.338683816672638e-09 8.029714328420384 -0.34313879615706766 TVQS(ph)LEIDLDSMR ddPTM_A459_Selumetinib_30min_R1 2 TVQSLEIDLDSMR 13 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 T(0.009)VQS(0.991)LEIDLDSMR;TVQS(1)LEIDLDSMR 262.42 6.9536e-30 49694000.0 3169.1 3540.6000000000004 3922.3 4117.4 4057.4 2685.1000000000004 4128.5 3803.8 1676.47 3208.2 True False 3242.9338640048436 3126.064906019717 3389.673203651691 3398.3733831703353 3690.4088863921497 2658.0903318757382 3817.083921125579 3702.91086751627 2844.8471454757596 3620.0037205143344 0.8958371632679106 0.8635529539112081 0.9363728507909053 0.9387762128287234 1.019448920861278 0.7342783425366407 1.0544419884141012 1.0229025032576917 0.7858685695139452 1.0 11.821775464723281 -6.3780141499148595 0.01089622879556816 1.8417899591693399 3.536555899728356e-05 0.04344655623628091 0.0985649943020762 9731.000385815516 32.39254613671788 2629.799670051051 2844.3598703043212 4.1877992046664784e-07 6.3780141499148595 -1.8417545936103425 TVQS(ph)LEIDLDSMR ddPTM_A459_Selumetinib_30min_R2 2 TVQSLEIDLDSMR 13 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 T(0.014)VQS(0.986)LEIDLDSMR;TVQS(1)LEIDLDSMR 125.61 0.0018519000000000003 1119000.0 20417.6 18525.8 16964.2 20836.7 19669.0 16984.7 17008.7 16400.2 14804.5 16899.2 True False 19282.871530128727 19946.66929016422 15872.741841224422 17998.705514687612 17198.00437690898 19324.18825324448 17799.638252099656 16447.92186680073 17765.813672291566 16411.276186605344 1.1749769677185213 1.2154246301969138 0.9671851025320952 1.0967279637507963 1.0479382700868658 1.1774945490842823 1.0845980562210922 1.002232957375082 1.082536998968537 1.0 14.002399810753209 -5.23820262630305 24.808593157665943 1.063754763395432 1.1952008343282903 0.47644203544398955 0.05749318637752563 641.51232136373 684904.33140485 0.014630753026250335 0.038659062283096304 5.778263913360633e-06 5.23820262630305 0.1314460709328582 TVQSLEIDLDSMR ddPTM_A459_Selumetinib_30min_R1 2 TVQSLEIDLDSMR 13 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ; 297.88 1.0859e-72 69005000.0 2939.4 3253.0 3197.1000000000004 3459.8 2989.0 2664.5 3208.8 3347.1 1775.3899999999999 2224.24 False True 3007.882300923242 2872.137247721328 2762.9513804132325 2855.610878489518 2718.64547775081 2637.6975491724343 2966.7576325802975 3258.32403508694 3012.7071606448144 2509.742869932298 1.1984822576682452 1.1443950223469728 1.1008902200757182 1.1378101369271147 1.0832366575561374 1.050983182688985 1.1820962490314109 1.2982700634885498 1.200404709477702 1.0 11.293323848329832 -7.497242845074685 23.835938384631763 1.1976390460954798 1.1186168140848383 0.05200053496021806 0.07921308449217472 697.1386036678965 648193.3112993422 0.03236633811266459 0.02170780154018452 3.182417507097452e-08 7.497242845074685 -0.07902223201064151 TVQSLEIDLDSMR ddPTM_A459_Selumetinib_30min_R2 3 TVQSLEIDLDSMR 13 0 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 0 ;; 238.07 1.5968e-16 43085400.0 27412.5 26836.4 29238.0 31899.0 34222.1 25118.8 27505.199999999997 27884.5 22914.699999999997 31892.7 False True 25889.022990932026 28894.665587373453 27356.85891192744 27554.301171155712 29922.813848544247 28578.686694236436 28784.246300519837 27965.63927847252 27498.280290213057 30971.874883813925 0.8358881432929258 0.932932400630159 0.8832806865762036 0.8896555754057932 0.9661285912071819 0.9227302771125366 0.9293672536292804 0.9029365959723517 0.887846809189579 1.0 14.918671098813519 TVQSPNS(ph)SVPSPGLAGPVTMTSVHPPIR ddPTM_A459_Selumetinib_30min_R2 1 TVQSPNSSVPSPGLAGPVTMTSVHPPIR 28 0 O15164-2;O15164 O15164-2 TRIM24 Transcription intermediary factor 1-alpha 1 T(0.029)VQS(0.047)PNS(0.461)S(0.461)VPS(0.001)PGLAGPVTMTSVHPPIR 74.171 7.3192e-05 5663800.0 41739.0 38427.0 48732.0 60889.0 52886.0 43850.0 35487.0 39500.0 41856.0 47893.0 True False 39419.313474455514 41374.227337720404 45596.6361753898 52595.81316061634 46241.98787316127 49889.93946933243 37137.215816156466 39614.938460422956 50228.369554354125 46510.20464904196 0.8475411744993793 0.8895731087386787 0.9803576767604918 1.130844586849173 0.9942331628530855 1.0726665222351388 0.7984745734057189 0.8517472404034878 1.0799429917234036 1.0 15.505259667412584 -5.17066833165127 3.652248523433584 0.9848644314638308 0.8576063328218384 0.20599407403129888 0.09541709035304018 0.424163223274318 10.437517257436578 0.026883009289567307 0.08386865402714448 6.750433578596414e-06 5.17066833165127 -0.12725809864199245 TVS(ph)ASESEDR ddPTM_A459_Selumetinib_30min_R2 1 TVSASESEDR 10 0 H3BNE2;Q9ULG6-3;Q9ULG6-4;Q9ULG6-2;Q9ULG6;Q9ULG6-5 H3BNE2 CCPG1 Cell cycle progression protein 1 1 T(0.051)VS(0.807)AS(0.139)ES(0.003)EDR 96.229 0.021921 2687200.0 21834.0 10554.0 16808.0 17068.0 17077.0 15773.0 25445.0 21545.0 15595.0 13928.0 True False 20620.553688427182 11363.457863541289 15726.59157916671 14743.308956057728 14931.634589682999 17945.587576961938 26628.24291831099 21607.692383033245 18714.435760707016 13525.862450710043 1.524527826862878 0.8401281548552759 1.1627052719541104 1.09000878944202 1.1039321628543664 1.326761058110559 1.9686909441337055 1.5975093981455464 1.3836038795237489 1.0 13.723432967220234 -7.005907082481298 10.962741412008047 1.553038777590741 1.134214146859023 0.2456505243636704 0.274193571999823 0.24658393549428012 420.67336121197883 0.09597169883777794 0.0803357903642457 9.864905231888222e-08 7.005907082481298 -0.41882463073171805 TVS(ph)ASSTGDLPK ddPTM_A459_Selumetinib_30min_R2 3 TVSASSTGDLPK 12 0 P78362;H7C5L6;P78362-2 P78362 SRPK2 SRSF protein kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal 1 T(0.036)VS(0.962)AS(0.001)S(0.001)TGDLPK;TVS(0.661)AS(0.339)STGDLPK;T(0.136)VS(0.852)AS(0.011)S(0.001)TGDLPK 184.96 0.00010448 24465500.0 142964.0 145648.0 141106.0 161459.0 149865.0 97045.0 141812.0 133904.0 104891.0 153532.0 True False 135018.6332102364 156818.73326786642 132027.3935845962 139468.0056676896 131037.61888990103 110412.0678632012 148406.53899514693 134293.63847099934 125872.13089941101 149099.13223595766 0.9055628371905071 1.0517749561391951 0.8855007511087021 0.9354045431127912 0.8788623845410899 0.740527903867797 0.9953548137375161 0.9007003357905008 0.8442177295855174 1.0 17.185912335528833 -5.297689268829471 24.267897414730818 0.8925912458996266 0.9786689484914187 0.14601031422203914 0.07770890406531049 625.5856224681476 418804.29582978156 0.01987240894885638 0.04137007231048798 5.038609848078799e-06 5.297689268829471 0.08607770259179215 TVS(ph)DNSLSNSR ddPTM_A459_Selumetinib_30min_R1 2 TVSDNSLSNSR 11 0 H0Y7W6;B7ZL14;Q96RU3-4;Q96RU3-3;Q96RU3-5;Q96RU3-2;Q96RU3 H0Y7W6;Q96RU3-5 FNBP1 Formin-binding protein 1 1 T(0.053)VS(0.728)DNS(0.219)LSNSR;T(0.336)VS(0.448)DNS(0.215)LSNSR 139.19 0.0011888 114931000.0 4837.6 4836.2 6648.3 6063.5 5141.7 4518.9 4670.4 4360.4 2893.1 3244.3 True False 4950.306667669002 4269.975455711616 5745.497376497852 5004.623550991728 4676.634142840866 4473.4439688329185 4318.107967839386 4244.748027424665 4909.379396336306 3660.7375071581146 1.3522703165658003 1.166424920487255 1.5694917664168082 1.3671080052054572 1.2775114669370018 1.2220062105206009 1.1795732306388715 1.1595335691577424 1.3410902548288777 1.0 11.83791861369975 -6.60818064345468 2.2851047183640834 1.1866626401371012 1.362716199732686 0.3463713853704301 0.11906603471147852 0.38201179290116544 4.058043079543074 0.04378217540953416 0.04454353412087876 2.46501380905032e-07 6.60818064345468 0.17605355959558477 TVS(ph)DSIKK ddPTM_A459_Selumetinib_30min_R1 2 TVSDSIKK 8 1 Q9Y490 Q9Y490 TLN1 Talin-1 1 T(0.067)VS(0.657)DS(0.276)IKK;T(0.186)VS(0.814)DS(0.001)IKK 117.7 0.015681 148445000.0 9975.0 11359.0 14497.7 15393.2 10661.3 12027.3 10184.1 11607.2 8440.4 10838.8 True False 10207.398092028754 10029.08299934417 12528.991970165742 12705.066586150888 9696.987297405392 11906.316281914653 9415.90513773405 11299.339350500784 14322.74233757456 12230.06555885256 0.8346151574502618 0.8200350972023007 1.0244419304111423 1.0388387964898933 0.7928810561760533 0.9735284103441648 0.7698981736789202 0.923898510284102 1.1711092036793904 1.0 13.578144516953422 -8.147127179459789 6.398817877121041 1.0832614131711504 0.8970635082232262 0.37878578583991906 0.09688835641178349 0.24340872430112548 11.737967783117822 0.06754785716568838 0.024994943677436234 7.126443077185498e-09 8.147127179459789 -0.1861979049479242 TVS(ph)EPNLK ddPTM_A459_Selumetinib_30min_R1 1 TVSEPNLK 8 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;F8VWY3;C9JEB6;H0YI41;C9JAH2;C9JF80 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.207)VS(0.793)EPNLK 121.6 0.0068133 49080000.0 4080.4 4253.3 4742.9 5019.7 5095.2 4124.7 4477.4 4204.9 2125.4 3306.7 True False 4175.465380923724 3755.321658694475 4098.840230884838 4143.1036264390505 4634.340059630626 4083.209262927954 4139.666113224579 4093.3723925598506 3606.6485669258514 3731.1471549855814 1.1190835438758941 1.00647910755184 1.0985469242101435 1.1104101377784068 1.2420684221575642 1.0943576045967378 1.1094888358110273 1.0970814665109796 0.9666326245285248 1.0 11.86540354526743 -8.216166396283189 5.5530726971639774 0.983061661694394 1.1103994303967388 0.4664549977189223 0.05411805814624217 0.173467094420729 13.382960766400075 0.04242421648034558 0.014849169042661604 6.079020440912268e-09 8.216166396283189 0.1273377687023448 TVS(ph)EPNLK ddPTM_A459_Selumetinib_30min_R2 2 TVSEPNLK 8 0 J3KPH8;Q8WUI4-8;Q8WUI4-5;Q8WUI4-6;Q8WUI4-7;Q8WUI4;Q8WUI4-4;Q8WUI4-3;F8VWY3;C9JEB6;H0YI41;C9JAH2;C9JF80 J3KPH8 HDAC7 Histone deacetylase;Histone deacetylase 7 1 T(0.14)VS(0.86)EPNLK;T(0.385)VS(0.615)EPNLK 104.22 0.014781 51993000.0 163399.0 142074.0 177479.0 197296.0 192975.0 127207.0 143588.0 158138.0 124844.0 162148.0 True False 154317.93771802276 152970.61896008736 166060.1943645248 170423.94444541656 168731.75528161137 144728.60957982598 150265.12651422413 158598.15539884492 149816.28843281194 157466.36592890124 0.9800057098396489 0.9714494778469468 1.0545756446776946 1.0822879123429183 1.0715415592800093 0.919108082072418 0.9542680789500877 1.0071874997766488 0.9514177046573651 1.0 17.264684183116493 -6.757191858432011 24.99999965473677 0.9660874803572331 1.0326607718870398 0.3962532595303382 0.04046659850408017 126.57627735520116 745001.2515148754 0.015068240685891836 0.014567110795867947 1.7490738289392506e-07 6.757191858432011 0.06657329152980662 TVS(ph)FEALPIMR ddPTM_A459_Selumetinib_30min_R2 1 TVSFEALPIMR 11 0 O15084-2;O15084;O15084-4;O15084-1 O15084-2 ANKRD28 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 1 T(0.039)VS(0.961)FEALPIMR 119.39 0.0050348 2356700.0 9967.8 6076.6 7506.4 11117.0 10876.0 8508.1 8032.9 7943.5 8439.4 10376.0 True False 9413.829580264919 6542.655680651416 7023.44639635037 9602.845422105338 9509.65964732636 9680.013546157978 8406.44576688938 7966.614269882781 10127.515816538034 10076.417919914378 0.934243662289953 0.649303724066559 0.697018171752254 0.9530018999238705 0.943753993026836 0.9606601892749037 0.8342692645047428 0.7906196758808586 1.005071037845966 1.0 13.298695243820832 -5.764646330616841 24.998628221791222 0.9163096476309944 0.7491000288130384 0.3925227531869042 0.09403603353698145 83.0231024850124 647184.7100039567 0.026372535700849457 0.04104711588133487 1.7193079422549694e-06 5.764646330616841 -0.16720961881795604 TVS(ph)PGS(ph)VSPIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R1 1 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 2 T(0.071)VS(0.753)PGS(0.698)VS(0.479)PIHGQGQVVENLK 127.3 0.00025124 20933000.0 4935.5 5945.4 5860.5 5967.6 5956.2 4927.3 4922.8 5191.5 3107.1 4170.8 True False 5050.487547188764 5249.309804058529 5064.6762894222065 4925.470685725773 5417.4627616525195 4877.735835630451 4551.469232630981 5053.8045556314 5272.521766394711 4706.16280703235 1.073164646926769 1.1154118587258737 1.0761795749722332 1.0466001470169528 1.1511422328095586 1.0364570958619879 0.9671295744018433 1.0738694692158914 1.1203441067776192 1.0 12.20033551530406 TVS(ph)PGSVS(ph)PIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R1 1 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 2 T(0.092)VS(0.836)PGS(0.417)VS(0.656)PIHGQGQVVENLK 111.33 0.00040945 32171000.0 3244.8 2911.8 3516.5 3640.0 3743.9 3134.9 3251.5 2794.9 1479.6 2014.4 True False 3320.3975267182855 2570.8851023409056 3038.978614751844 3004.342331262453 3405.26490603923 3103.3657522614617 3006.236737202332 2720.770172885331 2510.7731342916563 2272.9678619176107 1.4608202704269655 1.1310697108457812 1.3370090557232872 1.3217707041083333 1.4981579647880927 1.3653363975165396 1.3226041544934524 1.1970121612673958 1.104623244507038 1.0 11.150361570322524 -8.139818034721014 1.514182711555371 1.0123076630337893 1.3475907102958495 0.6324392998091524 0.09238891692361977 0.26647452936685573 1.1079672976997061 0.08768016667971236 0.02767731816598637 7.247395554856154e-09 8.139818034721014 0.33528304726206026 TVS(ph)PGSVS(ph)PIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R2 1 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 2 T(0.143)VS(0.695)PGS(0.416)VS(0.746)PIHGQGQVVENLK 76.90899999999998 0.010852 4027700.0 25108.0 25934.0 24763.0 25551.0 27017.0 23947.0 24995.0 21048.0 18526.0 25720.0 True False 23712.597875287596 27923.054409046792 23169.775539915827 22070.90972206649 23622.88292495552 27245.48188077773 26157.31702665291 21109.246195316035 22231.71765968952 24977.396771414577 0.949362261099424 1.1179329321061744 0.9276297186595729 0.8836353093179663 0.9457704155939408 1.090805504277326 1.047239520837043 0.8451339580542095 0.8900734477314564 1.0 14.608335501784442 -7.760447841189619 24.999969989057476 0.9007027807260098 0.9943423395699812 0.18603655218043613 0.0784396485782501 42.39437490006957 1068997.5340463538 0.04151206562860265 0.02219548669613231 1.73600974529453e-08 7.760447841189619 0.09363955884397135 TVS(ph)PPTVCTIPTVVGR ddPTM_A459_Selumetinib_30min_R2 1 TVSPPTVCTIPTVVGR 16 0 Q9BWT3-2;Q9BWT3;A0A0C4DH56 Q9BWT3-2 PAPOLG Poly(A) polymerase gamma 1 T(0.063)VS(0.872)PPT(0.063)VCT(0.001)IPT(0.001)VVGR 71.316 0.040272 7680500.0 10548.0 9211.1 9344.6 11165.0 11759.0 9137.7 11786.0 7446.6 8253.0 12555.0 True False 9961.784386989551 9917.561751645364 8743.378609631207 9644.307739300717 10281.729293206203 10396.335231218216 12334.072353515943 7468.268373149002 9903.830608086875 12192.504528192469 0.8170416803172088 0.8134146457533148 0.7171109585741042 0.791003006560333 0.8432827947229364 0.8526824990861387 1.0116110537417584 0.6125294729955019 0.812288450267659 1.0 13.573706887727996 -6.229423178062854 5.025881169357317 0.8438699090694185 0.7811527384673794 0.08997573510039303 0.10657142508190758 0.6147991081254999 41.876112897634705 0.03276886201084965 0.04150632713490625 5.896262662699067e-07 6.229423178062854 -0.06271717060203907 TVS(ph)PQSNSSRPTCAR ddPTM_A459_Selumetinib_30min_R1 1 TVSPQSNSSRPTCAR 15 1 Q9H7N4;M0R3G4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 TVS(0.639)PQS(0.228)NS(0.066)S(0.066)RPT(0.001)CAR 111.07 0.015875 793600.0 246.51 163.65 322.27 400.63 289.64 193.52 210.58 251.51 128.29 186.4 True False 252.25320337503842 144.48978192117903 278.50750410239664 330.6674912565048 263.4421131400953 191.57336450210138 194.69578106106943 244.839137780382 217.69876006912466 210.32625568975502 1.199342433724149 0.6869792905661332 1.324168983035639 1.57216458863919 1.252540308275585 0.9108390384921065 0.9256846246921185 1.164092124292536 1.0350527058792154 1.0 7.716485147257787 -6.7514181462692795 24.895217901796933 1.012298883363705 1.2049388903104943 0.17783709806722647 0.21474549366888643 417.75542834242003 1037806.0846832681 0.07894916363857955 0.07804322742485734 1.7724820825350903e-07 6.7514181462692795 0.1926400069467893 TVS(ph)PSTIR ddPTM_A459_Selumetinib_30min_R1 2 TVSPSTIR 8 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 T(0.075)VS(0.878)PS(0.047)TIR;T(0.02)VS(0.835)PS(0.144)T(0.001)IR 96.665 0.020894 23586000.0 7919.2 9666.4 9181.3 9911.5 10317.099999999999 8766.7 9287.599999999999 8563.1 4647.0 7313.5 True False 8103.701951919208 8534.653394212553 7934.529889270897 8180.642586897755 9383.920126631945 8678.514957526728 8587.02885451034 8335.97877113113 7885.6195965486195 8252.258964522654 0.9819980185738101 1.0342202578595683 0.9614979272199637 0.9913216032200655 1.1371335008964725 1.0516532497146047 1.0405670606590143 1.0101450774834375 0.9555710297567906 1.0 13.010573379877087 -1.5960576697488404 17.146088668773288 1.0199683848112167 0.00510876055271825 0.0 0.05067785585320421 0.0 0.0 0.012246932834461799 0.0 0.025347920143745345 1.5960576697488404 -1.0148596242584984 TVS(ph)PSTIR ddPTM_A459_Selumetinib_30min_R2 1 TVSPSTIR 8 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 1 T(0.007)VS(0.907)PS(0.039)T(0.047)IR 87.806 0.031954 63844000.0 77089.0 59552.0 61833.0 72435.0 72414.0 54361.0 51266.0 67420.0 46328.0 56436.0 True False 72804.70199171755 64119.44691013936 57854.732098680106 62569.22804265538 63316.70593062632 61848.734309974454 53649.970581651796 67616.1810380182 55594.8945124741 54806.54604166228 1.328394274953463 1.1699231486216572 1.0556171894996025 1.1416378619278824 1.1552763402111652 1.1284917364243117 0.9788971292018422 1.2337245442655411 1.0143842027595122 1.0 15.74206059714827 -4.8245738312331214 2.839139079442103 1.0987577615896476 1.358064324375643 0.4780798388187313 0.07585429307828208 0.3198568395863173 3.850096237022191 0.018371585587894434 0.1861628367478975 1.4977046175771602e-05 4.8245738312331214 0.2593065627859954 TVS(ph)SPIPYTPSPSSSR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSR 16 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 T(0.001)VS(0.424)S(0.424)PIPYT(0.151)PSPSSSR 175.6 1.2506e-06 4355500.0 1694.8 2444.7 1605.1 1632.5 1930.4 1727.5 1978.3 1883.2 987.52 1747.6 True False 1734.285542493267 2158.473387489804 1387.1362361831898 1347.4145208203179 1755.795660839801 1710.1229184445024 1829.0752382615328 1833.2514185042953 1675.749314392876 1971.9214830655346 0.8794901609353936 1.094604123960482 0.7034439495160618 0.6833002897892452 0.8903983631793767 0.8672368211060604 0.9275598719164345 0.9296776946992514 0.8498052933566951 1.0 10.945386393047723 -7.039670632472908 2.340553808186458 0.920871758517923 0.8465580190128161 0.09601202284717791 0.11094680453137648 0.9256531484630093 10.088381014363828 0.05175251714588928 0.03985065871409396 9.127027677647033e-08 7.039670632472908 -0.07431373950510689 TVS(ph)SPPTSPR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPPTSPR 10 0 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 1 TVS(0.499)S(0.499)PPT(0.002)SPR 131.09 0.002669 21760000.0 199820.0 180670.0 207440.0 196980.0 205720.0 206870.0 250170.0 217670.0 249700.0 166350.0 True False 188714.8043428377 194526.80805438777 194093.53624359443 170150.98419054676 179875.61443986563 235364.46472111283 261803.40070245098 218303.38366279178 299646.97720093204 161547.043270794 1.1681724439023227 1.2041496032106962 1.2014675868641198 1.0532596619879346 1.1134565560469483 1.4569407149506415 1.620601624157254 1.3513301094397605 1.8548589385114735 1.0 17.301594820226725 -6.793549200277953 6.563046319538478 1.4910929623304972 1.1486780866063875 0.3525285442244559 0.20669076017408589 0.18032126013022465 23.451930092517866 0.0677682522026257 0.060925061080792674 1.6086101316202157e-07 6.793549200277953 -0.34241487572410967 TVS(ph)TSSQPEENVDR ddPTM_A459_Selumetinib_30min_R2 1 TVSTSSQPEENVDR 14 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 TVS(0.453)T(0.453)S(0.087)S(0.006)QPEENVDR 238.02 2.124e-19 14765000.0 22133.0 16821.0 27281.0 23994.0 34163.0 20288.0 26400.0 31844.0 15294.0 30513.0 True False 20902.936465419018 18111.116611960213 25525.77016130695 20725.975808041312 29871.13851890498 23082.487843872674 27627.65231060757 31936.66076794201 18353.227350064302 29632.010407705027 0.7054174245289735 0.6112010748771501 0.8614255263176354 0.6994454821955673 1.0080699253243302 0.7789713733993113 0.9323583493148249 1.0777757002824795 0.619371655771693 1.0 14.854868889980734 -5.655992322144254 1.0271036568724596 0.9021056158945501 0.6476573594358015 0.28028391486295345 0.13702259713963924 0.843782242898588 1.6053333849629035 0.04931435164781684 0.17288883006318675 2.2080437684945675e-06 5.655992322144254 -0.2544482564587486 TVSAS(ph)STGDLPK ddPTM_A459_Selumetinib_30min_R2 1 TVSASSTGDLPK 12 0 P78362;H7C5L6;P78362-2 P78362 SRPK2 SRSF protein kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal 1 TVSAS(0.499)S(0.499)T(0.002)GDLPK 234.49 1.6225e-10 28511000.0 290100.0 291950.0 251190.0 293480.0 285860.0 219160.0 241780.0 244970.0 188200.0 205540.0 True False 273977.40336231224 314341.6262327907 235028.7088749936 253507.51771876102 249947.71117917553 249347.3006636011 253023.24907798122 245682.82214303364 225845.2587473581 199605.52614294566 1.3725942796098032 1.574814246413588 1.1774659420334883 1.2700425815726863 1.2522083732299965 1.24920038779404 1.2676164531475995 1.2308417852474192 1.1314579466383166 1.0 17.606792137139344 -1.5228787453639798 0.08359035089058109 0.8040089808761429 2.512384435886763 0.6292270224046721 0.08683399594889177 120.9130142093442 0.7361233252996536 2.157630460072224 23.775524016141933 0.029999999994222197 1.5228787453639798 1.70837545501062 TVSASS(ph)TGDLPK ddPTM_A459_Selumetinib_30min_R1 2 TVSASSTGDLPK 12 0 P78362;H7C5L6;P78362-2 P78362 SRPK2 SRSF protein kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal 1 TVSAS(0.023)S(0.97)T(0.007)GDLPK;TVSAS(0.006)S(0.991)T(0.003)GDLPK 231.74 4.267e-10 98385000.0 16878.4 18211.7 19355.8 19902.2 17032.4 15463.7 16651.7 15427.599999999999 8483.5 13240.2 True False 17271.63388035069 16079.46569761036 16727.388673798887 16426.65438056364 15491.822427314459 15308.149217916221 15395.648862639426 15018.40993209265 14395.8798896751 14939.708640469395 1.156089070811225 1.076290447462512 1.1196596316802951 1.0995297683427596 1.036956128136895 1.0246618315198448 1.0305186823346044 1.0052679268061537 0.9635984366307422 1.0 13.8668643919973 -6.442103878125239 0.6389380556962686 0.986128626324856 1.1334724399756204 0.8442518105136856 0.022461694834733877 0.32268837920099236 0.28869852690059716 0.01606577056226847 0.02466437674333685 3.6132342799440244e-07 6.442103878125239 0.14734381365076443 TVSASS(ph)TGDLPK ddPTM_A459_Selumetinib_30min_R2 3 TVSASSTGDLPK 12 0 P78362;H7C5L6;P78362-2 P78362 SRPK2 SRSF protein kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal 1 TVSAS(0.021)S(0.973)T(0.006)GDLPK;TVSAS(0.006)S(0.992)T(0.002)GDLPK;TVSAS(0.004)S(0.99)T(0.007)GDLPK 237.07 3.7473e-13 96744000.0 498840.0 487030.0 476240.0 491870.0 485670.0 364320.0 409313.0 418797.0 324147.0 435090.0 True False 471116.46981473855 524383.6349517255 445599.23689090635 424876.4574769231 424655.7926551113 414501.7730323195 428346.8655383226 420015.6299344241 388985.45742391195 422527.82120041957 1.1149951462989502 1.2410629753608395 1.0546033054697792 1.005558536405558 1.0050362871932221 0.9810046871107855 1.0137719791358848 0.9940543766825621 0.9206150172994234 1.0 18.688686812722587 -5.477134493463992 3.613451493141309 0.9907666850908358 1.1772599613905383 0.7933565084544684 0.03812097487540414 0.09187773873884596 2.432119851705261 0.010014874595954851 0.021558325654964988 3.333231723764231e-06 5.477134493463992 0.18649327629970258 TVSDNS(ph)LSNSR ddPTM_A459_Selumetinib_30min_R1 2 TVSDNSLSNSR 11 0 H0Y7W6;B7ZL14;Q96RU3-4;Q96RU3-3;Q96RU3-5;Q96RU3-2;Q96RU3 H0Y7W6;Q96RU3-5 FNBP1 Formin-binding protein 1 1 T(0.246)VS(0.096)DNS(0.658)LSNSR;T(0.428)VS(0.064)DNS(0.508)LSNSR 159.66 0.0005891 96601000.0 5807.1 5647.9 5353.7 6590.0 6624.4 5376.6 6317.0 6370.0 2995.8 4146.3 True False 5942.394131350393 4986.641242362524 4626.6969457690775 5439.180209620765 6025.224189632812 5322.516285562206 5840.503604154124 6201.046907323903 5083.653795425084 4678.517993382139 1.2701445499955397 1.065859156556891 0.9889236190421061 1.1625861474327124 1.2878488867961215 1.1376500620690175 1.24836617330865 1.3254297442257168 1.0865949009100784 1.0 12.19183588665003 -5.991274880288169 24.95722699169356 1.2008886578538287 1.0993458974011696 0.059865180545233154 0.1119069858911824 377.31816637057216 1079263.5889734381 0.03058695110831118 0.045292747032558124 1.0202934995709788e-06 5.991274880288169 -0.10154276045265909 TVSGPGT(ph)PEPR ddPTM_A459_Selumetinib_30min_R1 1 TVSGPGTPEPR 11 0 Q9H3U1 Q9H3U1 UNC45A Protein unc-45 homolog A 1 T(0.001)VS(0.019)GPGT(0.98)PEPR 125.36 0.0063437 0.0 2418.1 3299.2 2106.5 2424.4 2566.5 1959.0 2733.6 2491.8 1396.4 2531.5 True False 2474.437025196464 2912.9281302435306 1820.4488701762432 2001.0240516243666 2334.3605281523774 1939.294238629686 2527.4023511660134 2425.7093694928876 2369.588810979232 2856.4426838981462 0.8662652463306687 1.0197747522342369 0.637313284960405 0.7005300904177773 0.817226454887836 0.678919359930289 0.8848076544343273 0.8492063863793539 0.829559376190769 1.0 11.48000386640068 -8.958702071952676 0.794796101536933 1.0001593156751554 0.7955378797237028 0.2353794469970848 0.10582173015163743 2.315769395765053 2.4971809881226754 0.11523854029379263 0.03866137900809026 1.099760021238876e-09 8.958702071952676 -0.20462143595145255 TVSGPGT(ph)PEPR ddPTM_A459_Selumetinib_30min_R2 1 TVSGPGTPEPR 11 0 Q9H3U1 Q9H3U1 UNC45A Protein unc-45 homolog A 1 TVSGPGT(1)PEPR 112.5 0.017861000000000002 10032000.0 39282.0 29653.0 40478.0 43337.0 54813.0 35319.0 36365.0 52241.0 40885.0 40570.0 True False 37098.863698305235 31927.289750577012 37873.689549114126 37434.42583950514 47926.900905562674 40183.871656039955 38056.04455588049 52393.01266103685 49063.14242234731 39398.63868648095 0.9416280596272265 0.8103653023304175 0.9612943698511572 0.9501451595166459 1.216460834775189 1.019930459420377 0.9659228294336691 1.3298178416254451 1.2453004483929693 1.0 15.265858161662768 -6.111104240423973 4.391880695814532 1.131969057439132 0.9026013350043594 0.45810921449741226 0.11434528326531225 0.22151319742834671 7.021507404043056 0.036338702751234436 0.048169884534463185 7.742759318941097e-07 6.111104240423973 -0.22936772243477255 TVSGPGTPEPRPAT(ph)PGASSVEQLR ddPTM_A459_Selumetinib_30min_R2 2 TVSGPGTPEPRPATPGASSVEQLR 24 1 Q9H3U1 Q9H3U1 UNC45A Protein unc-45 homolog A 1 TVSGPGTPEPRPAT(0.414)PGAS(0.171)S(0.414)VEQLR;TVSGPGTPEPRPAT(0.826)PGAS(0.125)S(0.049)VEQLR 71.042 0.0018068 42001000.0 51716.0 59774.0 68131.0 63296.0 77754.0 46271.0 43376.0 35373.0 20115.3 67338.0 True False 48841.83175555097 64358.47359629689 63747.52563542401 54674.97560830969 67985.84739042062 52644.41024368259 45393.06994791342 35475.92957368462 24138.922068441774 65393.776974864544 0.7468880681769512 0.9841681666595646 0.9748255657404021 0.8360883579078962 1.0396378758876765 0.8050370031986005 0.6941496889736342 0.5424970267021054 0.3691317918174396 1.0 15.996865731562272 -7.244147648274418 2.430863219876078 0.5982454563279753 0.9182732180860566 0.3445316762769073 0.167730119210505 0.2856021529527293 3.3204361294681264 0.07508302639906966 0.05033340306706813 5.69970464931188e-08 7.244147648274418 0.32002776175808123 TVSGPGTPEPRPAT(ph)PGASSVEQLRK ddPTM_A459_Selumetinib_30min_R1 1 TVSGPGTPEPRPATPGASSVEQLRK 25 2 Q9H3U1 Q9H3U1 UNC45A Protein unc-45 homolog A 1 TVSGPGT(0.009)PEPRPAT(0.72)PGAS(0.135)S(0.135)VEQLRK 65.744 0.007002899999999999 11634000.0 853.39 766.44 1790.5 2028.3 1345.1 828.4 920.73 581.01 495.79 633.26 True False 873.2723265921226 676.7048484917108 1547.3599345124928 1674.0954809064924 1223.435942496693 820.067048127019 851.2785948160245 565.599727413541 841.3194189311042 714.5450894747545 1.2221374682373716 0.9470428926873471 2.1655175541825096 2.3428829132911417 1.7121885805639117 1.147677116821041 1.1913574207637192 0.791552185782006 1.1774196356867257 1.0 9.480881241416553 -6.813102855671183 4.4343004864454345 1.0437576759051919 1.70329692205041 0.38344338794619925 0.39159353667040825 0.2523344129554012 10.324358441141843 0.15856412287574367 0.14273972811196906 1.5377903962210157e-07 6.813102855671183 0.6595392461452181 TVSLGAGAKDELHIVEAEAMNYEGS(ph)PIK ddPTM_A459_Selumetinib_30min_R1 7 TVSLGAGAKDELHIVEAEAMNYEGSPIK 28 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 TVSLGAGAKDELHIVEAEAMNY(0.002)EGS(0.998)PIK;TVSLGAGAKDELHIVEAEAMNY(0.001)EGS(0.999)PIK;TVSLGAGAKDELHIVEAEAMNYEGS(1)PIK;TVSLGAGAKDELHIVEAEAMNYEGS(1)PIK;T(0.001)VS(0.001)LGAGAKDELHIVEAEAMNY(0.049)EGS(0.949)PIK;TVSLGAGAKDELHIVEAEAMNYEGS(1)PIK;TVSLGAGAKDELHIVEAEAMNY(0.021)EGS(0.979)PIK 173.03 1.5519e-22 280850400.0 22209.6 30768.899999999998 25594.399999999998 25668.9 24169.0 25176.899999999998 25864.9 23854.13 13201.27 21702.34 True False 22727.040467641276 27166.462883926448 22118.821059975722 21186.308479929336 21982.918217383518 24923.643244796185 23913.889769049554 23221.44098326567 22401.59100738743 24488.046737693112 0.928087107603351 1.10937647150561 0.9032497077821005 0.8651693908815687 0.8976999453184812 1.0177881278882315 0.9765535824562198 0.948276570687942 0.914796972063349 1.0 14.57979008304601 -5.290948459547479 24.997535227197417 0.9384318033755552 1.0187318812268493 0.20944669285674478 0.060740460582343586 923.8134005954471 782572.7805471487 0.016159736113259826 0.03364425414864024 5.11742563639317e-06 5.290948459547479 0.08030007785129412 TVSLGAGAKDELHIVEAEAMNYEGS(ph)PIK ddPTM_A459_Selumetinib_30min_R2 3 TVSLGAGAKDELHIVEAEAMNYEGSPIK 28 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 TVSLGAGAKDELHIVEAEAMNY(0.002)EGS(0.998)PIK;TVSLGAGAKDELHIVEAEAMNY(0.05)EGS(0.95)PIK;TVSLGAGAKDELHIVEAEAMNY(0.089)EGS(0.911)PIK 128.62 1.8013e-12 76042000.0 383462.0 362328.0 395715.0 409829.0 361317.0 290381.0 321193.0 307488.0 219681.0 420087.0 True False 362150.71716000966 390117.3925318535 370255.1277219153 354009.5832055416 315925.1282450369 330378.3469337341 336129.11093185504 308382.7391726216 263623.3383999918 407957.9967928948 0.8877156962408074 0.9562685266588896 0.9075814927826508 0.8677598821166366 0.7744060190721556 0.8098342219810805 0.8239306829974836 0.7559178680082992 0.6462021592233272 1.0 18.638061094922676 -6.016503444641329 2.4744676894102224 0.790725851893141 0.9222993206250717 0.272519464893073 0.08389219561811088 0.34202209829494307 4.194240704241226 0.025293429902408723 0.03803774932837088 9.62712377113018e-07 6.016503444641329 0.13157346873193065 TVSLGAGAKDELHIVEAEAMNYEGS(ph)PIKVTLATLK ddPTM_A459_Selumetinib_30min_R1 4 TVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLK 35 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 TVSLGAGAKDELHIVEAEAMNY(0.331)EGS(0.664)PIKVT(0.004)LAT(0.001)LK;TVSLGAGAKDELHIVEAEAMNY(0.24)EGS(0.755)PIKVT(0.004)LAT(0.001)LK;TVSLGAGAKDELHIVEAEAMNY(0.24)EGS(0.646)PIKVT(0.05)LAT(0.063)LK;TVSLGAGAKDELHIVEAEAMNY(0.189)EGS(0.761)PIKVT(0.027)LAT(0.022)LK 79.911 1.3258e-05 259886000.0 13456.210000000001 14280.460000000001 25696.170000000002 24287.41 17811.9 16923.04 13346.07 13150.5 8217.42 9994.76 True False 13769.713511773265 12608.497104394257 22206.77125295832 20046.069774650292 16200.816789946372 16752.809582490918 12339.365194917405 12801.706021155871 13944.36156338941 11277.684803206741 1.2209698845154753 1.1180040340202724 1.9690895463441183 1.777498673216183 1.4365374695823887 1.4854830468153675 1.0941399241277592 1.1351360003886422 1.2364560463176286 1.0 13.461183306704958 -7.232053461372732 5.854711223957335 1.1270035723115097 1.516489289193663 0.3890768205348346 0.235692364584317 0.22138080263143728 24.689911182687133 0.10216791750684334 0.07658354534160677 5.860660157219886e-08 7.232053461372732 0.3894857168821533 TVSLPLS(ph)SPNIK ddPTM_A459_Selumetinib_30min_R1 1 TVSLPLSSPNIK 12 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 TVSLPLS(0.5)S(0.5)PNIK 244.71 6.429400000000002e-14 81349000.0 6173.5 7017.8 7429.8 7532.8 6200.6 5300.3 5880.6 5748.7 3472.8 5115.2 True False 6317.330538460104 6196.152713513295 6420.873968970071 6217.337888168628 5639.756824804846 5246.983794287349 5437.021607501779 5596.2258015907255 5893.08795672349 5771.78574626735 1.0945192382696398 1.0735243797849539 1.1124588214527003 1.0771948512103762 0.9771251173784667 0.9090745957922306 0.9419999020264975 0.9695830801082386 1.0210164090956748 1.0 12.494802031384026 -6.259116605482499 4.094688610124457 0.9627315673540722 1.0916950750595482 0.7931621743113831 0.02994475198276616 0.09569184001536017 3.8913318875390264 0.009801909354839895 0.012063229395992683 5.506598276703831e-07 6.259116605482499 0.12896350770547604 TVSLPLS(ph)SPNIK ddPTM_A459_Selumetinib_30min_R2 1 TVSLPLSSPNIK 12 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 TVSLPLS(0.813)S(0.187)PNIK 112.64 0.0062904 41027000.0 129920.0 119250.0 131420.0 142020.0 154930.0 116340.0 133310.0 114940.0 92827.0 116980.0 True False 122699.56651096733 128396.09155081488 122964.58027927708 122676.63100183517 135466.30830822673 132364.77897063017 139509.17914875378 115274.45637065877 111394.9938030874 113602.4834494586 1.0800782059096092 1.1302225765859943 1.0824110225898684 1.079876313235825 1.1924590395816064 1.1651574415582109 1.2280469133478142 1.014717749739547 0.9805682976345029 1.0 16.79363484819715 -7.901512941379111 7.713152456623068 0.9928319059547561 1.1353696130339523 0.6492016354760859 0.046837480663528205 0.1530550969735081 10.386280584707723 0.027957962930042077 0.013354806175004045 1.2545473535128297e-08 7.901512941379111 0.14253770707919622 TVSLPLSS(ph)PNIK ddPTM_A459_Selumetinib_30min_R1 1 TVSLPLSSPNIK 12 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 TVSLPLS(0.061)S(0.939)PNIK 260.5 3.7955e-25 72353000.0 4473.9 5419.4 5933.5 5616.2 4982.6 4374.7 4648.9 4372.3 2478.4 4647.4 True False 4578.1331653060115 4784.894128589294 5127.763290382503 4635.436099130823 4531.924709749478 4330.69448990979 4298.229730149139 4256.332400768019 4205.663784825932 5243.939059509485 0.8730332510260422 0.912461810537682 0.9778457057169065 0.8839607109325217 0.8642214675495089 0.8258476005849849 0.8196566896319335 0.811667022149978 0.8020047024000557 1.0 12.35643520457448 -6.217949809812996 2.5922800341160497 0.8394011824731616 0.9205391483396567 0.1813718318459857 0.05904090535598243 0.37620886983809393 4.990732538082395 0.018319160031984732 0.023867510317749804 6.054108363321273e-07 6.217949809812996 0.08113796586649502 TVSLPLSS(ph)PNIK ddPTM_A459_Selumetinib_30min_R2 1 TVSLPLSSPNIK 12 0 A0A0A0MQZ8;Q8IWZ3-6;Q8IWZ3;Q8IWZ3-4;H0Y785;H0Y472;H0Y4P6;H0Y7Y3 A0A0A0MQZ8;Q8IWZ3-6 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 TVSLPLS(0.329)S(0.671)PNIK 124.39 0.003065 48996000.0 102720.0 91794.0 100600.0 107690.0 119440.0 91780.0 86641.0 90530.0 71346.0 96075.0 True False 97011.23362074012 98834.30463576909 94127.50552499828 93022.43622438806 104434.87939285215 104421.86190411235 90669.97817588453 90793.42731195163 85617.19357379944 93301.06511717151 1.0397655535755055 1.059305212771673 1.0088577810637949 0.9970136579637806 1.119332124040581 1.119192602710107 0.9718000331723678 0.9731231599331617 0.917644331994256 1.0 16.509605930406657 -7.398095218764577 7.47875035507893 0.9617271346418457 1.0551060604530007 0.5343516260080395 0.041891872060166355 0.2322199749599389 13.099731277274914 0.019131582963700197 0.012833717962516807 3.998570717635404e-08 7.398095218764577 0.09337892581115503 TVSLTPS(ph)PTTQVETPDLVDHDNT(ph)SPLFR ddPTM_A459_Selumetinib_30min_R1 1 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 2 T(0.001)VS(0.003)LT(0.076)PS(0.495)PT(0.192)T(0.233)QVETPDLVDHDNT(0.548)S(0.452)PLFR 135.78 7.2962e-12 8922900.0 1205.9 1476.3 1386.1 1486.5 1370.3 1125.0 1448.8 1059.2 774.33 1304.7 True False 1233.9951237270648 1303.4541096867492 1197.875233302298 1226.9106800608893 1246.3566069461137 1113.6835214182722 1339.515849564429 1031.1065752335126 1313.9814551744118 1472.170953854202 0.8382145568735863 0.8853958884830968 0.8136794372733772 0.8334023143499663 0.8466113284487122 0.7564906225751871 0.9098915082229568 0.7003986680582405 0.8925467872697503 1.0 10.52372949678873 -8.531065519576497 24.39827925012737 1.0000000048810633 0.8247084215861247 0.4851119263752579 0.056484586479158085 630.7032802419333 1879627.4201810465 0.05065383694840054 0.013078764462367281 2.9439774589011454e-09 8.531065519576497 -0.17529158329493866 TVSLTPS(ph)PTTQVETPDLVDHDNT(ph)SPLFR ddPTM_A459_Selumetinib_30min_R2 2 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 2 T(0.002)VS(0.019)LT(0.278)PS(0.34)PT(0.138)T(0.158)QVET(0.067)PDLVDHDNT(0.526)S(0.474)PLFR;T(0.002)VS(0.017)LT(0.171)PS(0.751)PT(0.04)T(0.043)QVET(0.039)PDLVDHDNT(0.496)S(0.442)PLFR 68.72800000000001 0.0033772 4631300.0 14277.0 12997.7 12211.4 12869.400000000001 13858.0 10841.9 11351.4 13183.3 9326.0 10880.8 True False 13483.541495359284 13994.581795807337 11425.731818767032 11116.565519046722 12117.034147908113 12335.273312030902 11879.262592372379 13221.661220387197 11191.460590211827 10566.643032286469 1.2760477905953866 1.3244113341433765 1.0813019597478224 1.0520432539530256 1.1467250394363102 1.1673786342871968 1.1242229491499987 1.2512641129248236 1.0591311314308833 1.0 13.36722949232472 -5.258422702876616 24.978261013408467 1.1209941139128987 1.300229577491902 0.5539103514169363 0.0676462248863322 192.93137663383285 1597461.744257881 0.01727860935688571 0.041803837781200504 5.515403585665809e-06 5.258422702876616 0.17923546357900322 TVSLTPSPT(ph)TQVETPDLVDHDNTSPLFR ddPTM_A459_Selumetinib_30min_R2 4 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 TVSLT(0.006)PS(0.138)PT(0.428)T(0.428)QVETPDLVDHDNTSPLFR;TVSLT(0.003)PS(0.021)PT(0.488)T(0.488)QVETPDLVDHDNTSPLFR;TVSLT(0.001)PS(0.032)PT(0.462)T(0.462)QVET(0.042)PDLVDHDNTSPLFR;TVSLT(0.004)PS(0.114)PT(0.788)T(0.093)QVETPDLVDHDNTSPLFR 167.62 1.253e-21 86974000.0 176821.0 173076.0 195558.0 215944.0 229212.0 154925.0 159076.0 175303.0 153796.0 179749.0 True False 166993.99669054578 186350.37267294625 182976.01118745172 186532.05467582197 200416.33937872105 176264.51248087425 166473.34920311396 175813.1027070259 184559.4974192818 174559.17932601093 0.9566612156136675 1.0675484004477003 1.0482176411113924 1.068589205082422 1.1481283319075342 1.009769369685672 0.953678573913345 1.0071833711974156 1.0572889843540914 1.0 17.413356698528354 -6.967871526712937 24.999212626240208 1.0017916055658815 1.0604843793188454 0.2191847173181417 0.04914659404688812 286.1177901402297 222627.91619172637 0.017763922888759658 0.015666204273481144 1.0767837014019445e-07 6.967871526712937 0.05869277375296389 TVSLTPSPTT(ph)QVET(ph)PDLVDHDNTSPLFR ddPTM_A459_Selumetinib_30min_R2 1 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 2 TVS(0.003)LT(0.026)PS(0.067)PT(0.435)T(0.468)QVET(0.417)PDLVDHDNT(0.302)S(0.281)PLFR 63.776 0.008564299999999999 0.0 8293.1 6755.4 8432.4 8090.2 8614.8 7581.1 6354.9 7349.7 6390.7 7756.3 True False 7832.2027019096495 7273.5174579653985 7889.868564502937 6988.300803626565 7532.531806710839 8625.327710626143 6650.415441995461 7371.086410191662 7669.018571077287 7532.355465712398 1.0398078977502017 0.9656365118553896 1.0474636520299598 0.9277709788707672 1.0000234111360309 1.1451036465138962 0.8829131169218494 0.9785898240922326 1.0181434753029095 1.0 12.878885369654009 -8.741111010494697 0.0032290822197790867 0.2807507743320696 1.7068985673756931 0.002822025078119572 0.0675686010530372 193982.8785077371 334.3529080538958 74269.52841350289 73390.03521515233 1.8150516561040457e-09 8.741111010494697 1.4261477930436235 TVSLTPSPTT(ph)QVETPDLVDHDNT(ph)SPLFR ddPTM_A459_Selumetinib_30min_R2 3 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 2 TVSLT(0.001)PS(0.014)PT(0.531)T(0.578)QVET(0.265)PDLVDHDNT(0.349)S(0.262)PLFR;TVS(0.002)LT(0.053)PS(0.099)PT(0.394)T(0.443)QVET(0.158)PDLVDHDNT(0.455)S(0.395)PLFR;TVS(0.003)LT(0.026)PS(0.099)PT(0.405)T(0.466)QVET(0.004)PDLVDHDNT(0.533)S(0.464)PLFR 96.957 4.5331e-06 7090900.0 29014.5 24685.8 28139.0 32369.4 31502.4 22579.2 24579.6 25664.5 22385.0 29112.3 True False 27401.990244246146 26579.12148264237 26328.56737542669 27960.631879670447 27544.786876970746 25689.27984642989 25722.600103553406 25739.17944601329 26862.62548915848 28271.7522561607 0.9692356524620781 0.940129965833671 0.9312676178283017 0.9889953628034337 0.974286511405336 0.9086553820105698 0.9098339526496166 0.9104203804843566 0.9501577845534792 1.0 14.787073682348222 -6.755536180060467 24.999949392338436 0.9285910516608301 0.9595632373109884 0.1254173426413583 0.02999778615889418 239.52816578971684 1014395.5995763256 0.009958029575389802 0.009709167922556952 1.755754620283547e-07 6.755536180060467 0.030972185650158246 TVSLTPSPTT(ph)QVETPDLVDHDNTSPLFR ddPTM_A459_Selumetinib_30min_R1 2 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 TVSLTPSPT(0.2)T(0.797)QVET(0.003)PDLVDHDNTSPLFR;TVSLTPS(0.002)PT(0.153)T(0.587)QVET(0.257)PDLVDHDNTSPLFR 141.69 1.1529e-12 142882000.0 9360.8 12465.8 11149.199999999999 14575.5 22514.3 9792.0 15202.9 11734.5 4996.200000000001 8729.6 True False 9578.888427053915 11006.2983408068 9635.19987817184 12030.162541020845 20477.885540222498 9693.50137042464 14056.133013074983 11423.262940972107 8478.186491989718 9850.129193504745 0.9724632275250066 1.1173760388913927 0.9781800511332753 1.2213202796318279 2.0789458836464583 0.9840989067246563 1.4269998633463317 1.159706915164595 0.8607183038350709 1.0 13.265926931627678 -8.099710075092858 4.700566272173007 0.9378610511441187 1.260601663954828 0.14324319407568642 0.3113791502911577 0.46527758849705064 16.360598651483038 0.23186477580806428 0.08337917448717938 7.948586868400155e-09 8.099710075092858 0.3227406128107094 TVSLTPSPTTQVET(ph)PDLVDHDNTSPLFR ddPTM_A459_Selumetinib_30min_R1 1 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 TVSLTPSPTTQVET(0.998)PDLVDHDNT(0.001)S(0.001)PLFR 86.039 4.137e-05 3496100.0 642.76 834.08 772.67 803.63 905.62 868.85 974.76 664.89 588.13 786.16 True False 657.735057406757 736.4255258467275 667.7456579725034 663.2911065034189 823.7068309001975 860.110157852681 901.2330684162214 647.2549573329024 998.0136546843427 887.0712938468762 0.7414680893960858 0.8301762563560616 0.7527530905399447 0.7477314519185809 0.9285689173055165 0.9696065736979546 1.0159646407989726 0.7296538190589108 1.125065889976389 1.0 9.792906248242426 -6.32062984967547 5.059447628582254 0.9529896224473735 0.7713061122495058 0.4948711898733228 0.09565200011603957 0.19220700054654966 10.360213401768577 0.028715747410869366 0.03307766903278584 4.779364466011188e-07 6.32062984967547 -0.18168351019786766 TVSLTPSPTTQVETPDLVDHDNT(ph)SPLFR ddPTM_A459_Selumetinib_30min_R1 1 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 TVSLTPSPTTQVET(0.005)PDLVDHDNT(0.619)S(0.376)PLFR 183.91 6.8685e-27 56593000.0 8737.8 11470.0 10140.0 10496.0 11339.0 9628.2 12100.0 10182.0 4789.5 8670.8 True False 8941.373739200888 10127.087067741668 8763.04369503305 8663.070634321626 10313.389452063044 9531.349049706141 11187.287258234117 9911.940284202812 8127.4316887604045 9783.781640744251 0.9138975160652418 1.0350892364122 0.8956704081108708 0.8854521648607263 1.0541311969916884 0.9741988731650691 1.1434522630436692 1.0130990907365356 0.8307045258363055 1.0 13.256176490108455 -6.264609797491365 24.967759392240836 1.0088754024062088 0.9372205453141749 0.14470233058564141 0.08229919881936829 576.0473020860594 4536491.52693139 0.025852593045257378 0.030577930626482345 5.437386473881667e-07 6.264609797491365 -0.0716548570920339 TVSLTPSPTTQVETPDLVDHDNT(ph)SPLFR ddPTM_A459_Selumetinib_30min_R2 3 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 TVSLTPSPTTQVETPDLVDHDNT(0.5)S(0.5)PLFR;TVSLTPSPTTQVETPDLVDHDNT(0.591)S(0.408)PLFR;TVSLTPSPTTQVETPDLVDHDNT(0.5)S(0.5)PLFR 133.57 3.5654e-12 33630300.0 111998.0 86872.0 110118.0 126426.0 117118.0 85467.0 91199.0 103205.0 92707.0 100485.0 True False 105773.5995235169 93534.80306249388 103033.1277674129 109206.5607029856 102404.58979179563 97239.30345782054 95439.93420739028 103505.3094634925 111250.99045000735 97583.73695861558 1.0839265109141554 0.9585081077819472 1.0558432273515856 1.1191061554580468 1.0494022158141425 0.9964703800906793 0.9780311472173435 1.0606819608413665 1.1400566725292343 1.0 16.57435311172128 -10.951077487177239 5.358110314119687 0.999960789082394 1.045415362604351 0.06250092310322186 0.05542313430385426 2.7030819923488856e-05 2.8845848178349396e-06 0.05587312315835734 0.013539535483570987 1.1192381702599576e-11 10.951077487177239 0.04545457352195692 TVSLTPSPTTQVETPDLVDHDNTS(ph)PLFR ddPTM_A459_Selumetinib_30min_R2 1 TVSLTPSPTTQVETPDLVDHDNTSPLFR 28 0 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 TVSLTPSPTTQVETPDLVDHDNT(0.251)S(0.749)PLFR 106.55 1.7948e-06 0.0 7458.4 5764.2 7721.6 7733.7 7243.1 5073.5 5370.9 7262.5 5965.7 6228.2 True False 7043.891986340806 6206.29560517574 7224.800662642412 6680.3567186233695 6333.157023864428 5772.328572352521 5620.657492236451 7283.632672628406 7159.00669558511 6048.375683193015 1.164592339380322 1.0261094763709118 1.194502630304265 1.1044877283642414 1.0470839371738683 0.9543601248831877 0.9292837923171521 1.2042295409770716 1.1836246738902598 1.0 12.562332037224815 -4.740101279119326 23.855834424644254 1.0739060529041828 1.164592944391645 0.08074463740960958 0.09390103119656792 2906.7124167690695 3249381.316748829 0.02511635049359536 1.0678157511220157 1.8192765469498434e-05 4.740101279119326 0.09068689148746212 TVSPGS(ph)VS(ph)PIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R2 1 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 2 T(0.026)VS(0.306)PGS(0.873)VS(0.795)PIHGQGQVVENLK 83.31700000000002 0.0055255 40162000.0 255340.0 233670.0 288700.0 258380.0 286480.0 228540.0 233640.0 252470.0 193070.0 231530.0 True False 241149.22500700701 251591.73763252754 270125.3563127928 223188.19826963858 250489.82123630546 260019.3105204387 244504.72294887697 253204.64590134175 231689.3948265273 224845.12731281528 1.0725125684912384 1.1189557035963742 1.2013840795268003 0.9926307985279508 1.1140549240714124 1.1564373826019696 1.0874361649328086 1.1261291224206578 1.0304399192257787 1.0 17.778572093699204 -8.395858871288965 3.8686910582925123 1.0013023229779605 1.1092564414449746 0.3493841379071758 0.051637551514236206 0.24572373339863546 6.019035559426677 0.04887759524617716 0.012911317147758741 4.019213983556392e-09 8.395858871288965 0.10795411846701408 TVSPGSVS(ph)PIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R1 4 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 1 TVSPGS(0.016)VS(0.984)PIHGQGQVVENLK;T(0.001)VS(0.002)PGS(0.03)VS(0.967)PIHGQGQVVENLK;T(0.006)VS(0.006)PGS(0.209)VS(0.779)PIHGQGQVVENLK;TVSPGS(0.024)VS(0.976)PIHGQGQVVENLK 135.86 2.3318000000000006e-05 198507000.0 10034.7 11438.0 12444.7 12329.3 11949.8 9761.6 11081.7 10899.800000000001 6084.099999999999 9092.0 True False 10268.488985872775 10098.833642618058 10754.77809384396 10176.219204624771 10868.942699908548 9663.407166823654 10245.798447072144 10610.701896459816 10324.273334917467 10259.046763579685 1.0009203800811797 0.9843832351432109 1.048321383232617 0.9919263884000453 1.059449571717914 0.9419400641714012 0.9987086211016628 1.0342775640840756 1.0063579563326819 1.0 13.324609066308717 -10.88418091141493 2.892559773385223 0.9998932544475371 1.0075841859711496 0.004685129265468491 0.03206144255218728 12569688.883323995 9089159.17816893 10401.118662225444 0.007789332784322729 1.3056268977683734e-11 10.88418091141493 0.007690931523612554 TVSPGSVS(ph)PIHGQGQVVENLK ddPTM_A459_Selumetinib_30min_R2 4 TVSPGSVSPIHGQGQVVENLK 21 0 A0A087WVF7;Q9NZM3-2;Q9NZM3;Q9NZM3-4;Q9NZM3-3 A0A087WVF7 ITSN2 Intersectin-2 1 T(0.001)VS(0.005)PGS(0.036)VS(0.959)PIHGQGQVVENLK;T(0.001)VS(0.003)PGS(0.196)VS(0.8)PIHGQGQVVENLK;TVS(0.002)PGS(0.133)VS(0.864)PIHGQGQVVENLK;TVSPGS(0.042)VS(0.958)PIHGQGQVVENLK 127.53 4.1118e-05 330843000.0 499145.0 414075.0 522331.0 606060.0 630020.0 436008.0 416659.0 470946.0 373498.0 506055.0 True False 471404.5191357509 445833.2210390235 488724.79213099164 523513.58248818433 550871.2551497386 496064.1443134476 436034.46909414517 472316.3748906928 448208.0364060622 491443.87726120575 0.9592235063805591 0.9071905087588671 0.9944671502565716 1.0652560886620495 1.1209240375924896 1.0094014133983933 0.8872518089433636 0.9610789690226489 0.9120228313839315 1.0 18.90666714508197 -9.790767769824775 9.12114153164887 0.9999462200468209 0.9822359584595518 0.006525386558603019 0.06897475969227693 0.0 0.0 0.07512288254184935 0.018219975271818463 1.618945504535093e-10 9.790767769824775 -0.01771026158726907 TVSQQS(ph)FDGVSLDSSGPEDR ddPTM_A459_Selumetinib_30min_R1 2 TVSQQSFDGVSLDSSGPEDR 20 0 H7C1J4;Q6BDS2 H7C1J4 UHRF1BP1 UHRF1-binding protein 1 1 TVSQQS(0.611)FDGVS(0.389)LDSSGPEDR;TVS(0.001)QQS(0.996)FDGVS(0.002)LDSSGPEDR 254.54 1.7166999999999996e-38 12790500.0 2321.24 2721.63 2852.09 2864.0 2819.0 2557.46 2843.31 3051.9 1475.74 2229.29 True False 2375.320375653216 2402.9802943485406 2464.7918434089556 2363.8561639383706 2564.021947734872 2531.7342743878876 2628.8368375379855 2970.95369803168 2504.2229962149027 2515.441086623466 0.9442957691534183 0.9552918202406067 0.9798646672808791 0.939738233786834 1.0193130586002381 1.0064772686790657 1.0450798675101285 1.181086575165892 0.995540308827657 1.0 11.296595685761762 -6.781826662735742 1.3749542910526151 1.068656605266671 0.9567052869929529 0.407664199357497 0.05102464483058308 0.369480687789157 1.4595664862144815 0.02358490919047324 0.02092795732152045 1.6526212670967072e-07 6.781826662735742 -0.11195131827371818 TVSQQS(ph)FDGVSLDSSGPEDR ddPTM_A459_Selumetinib_30min_R2 1 TVSQQSFDGVSLDSSGPEDR 20 0 H7C1J4;Q6BDS2 H7C1J4 UHRF1BP1 UHRF1-binding protein 1 1 TVS(0.001)QQS(0.997)FDGVS(0.001)LDSSGPEDR 199.36 1.1689e-15 3587900.0 23521.0 24313.0 25301.0 33768.0 30329.0 20457.0 21511.0 20777.0 24775.0 23100.0 True False 22213.796982023254 26177.72892138331 23673.161205645934 29168.740146950888 26518.799875299843 23274.766059843423 22511.30412323785 20837.4576301825 29730.692271337997 22433.042978992096 0.9902266492702679 1.166927239692716 1.055280874191485 1.3002578461721213 1.1821311937098298 1.0375215739407078 1.0034886548525335 0.9288734323602992 1.325308042211658 1.0 14.453337710759914 -6.770501639335471 24.780235723426244 1.0511210581145485 1.1448298552669391 0.0918270075093246 0.12375332921347552 398.1465769067968 1088702.1196447427 0.04289947849314156 0.038378363782786945 1.6962831992718297e-07 6.770501639335471 0.09370879715239067 TVSQQSFDGVS(ph)LDSSGPEDR ddPTM_A459_Selumetinib_30min_R2 1 TVSQQSFDGVSLDSSGPEDR 20 0 H7C1J4;Q6BDS2 H7C1J4 UHRF1BP1 UHRF1-binding protein 1 1 TVSQQS(0.242)FDGVS(0.747)LDS(0.01)SGPEDR 166.21 3.4766e-09 4280200.0 14219.0 13138.0 15258.0 21728.0 19662.0 12023.0 12502.0 15547.0 12266.0 15295.0 True False 13428.764903166899 14145.642354671736 14276.316891654316 18768.60891710936 17191.88377948979 13679.059116072609 13083.367772243024 15592.239196055596 14719.542740675359 14853.3936088175 0.9040873255519943 0.9523508719431216 0.9611484935792309 1.2635906252405276 1.1574381068905413 0.9209383038198244 0.8808335735798636 1.0497425441415282 0.990988532878932 1.0 13.858504966014698 -10.200654739428341 14.970009989722985 0.9999999920320688 1.0126293427079802 0.0 0.1138592862311565 0.0 0.0 0.12085605280519011 0.029311898306530856 6.300068341197289e-11 10.200654739428341 0.012629350675911422 TVSS(ph)DGCSTPSR ddPTM_A459_Selumetinib_30min_R2 1 TVSSDGCSTPSR 12 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.004)VS(0.062)S(0.921)DGCS(0.012)TPSR 85.973 0.030525 10018000.0 6484.8 7510.7 9779.5 11321.0 9616.5 7489.0 8807.2 9583.8 10371.0 8914.9 True False 6124.400776711205 8086.746539293116 9150.297617114516 9779.060270185708 8408.38929739922 8520.541771626697 9216.752251135722 9611.687271316501 12445.489789951422 8657.50367330808 0.7074095498906139 0.9340737058218453 1.0569210204698807 1.1295473428830871 0.9712256112952163 0.9841799776414014 1.0645969784052023 1.1102146339192742 1.4375379161919468 1.0 13.07973537920844 -4.247144573517899 0.9474935138371334 1.1014321939375524 5.4255951367513744e-21 0.48528828232832877 0.12491541392130415 4.570272781187679 1.6098454237758384 0.04289441389445892 6.5828531338928435 5.660508234116461e-05 4.247144573517899 -1.1014321939375524 TVSS(ph)PIPYT(ph)PSPSSS(ph)RPISPGLSYASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 3 T(0.061)VS(0.192)S(0.535)PIPY(0.453)T(0.471)PS(0.164)PS(0.169)S(0.168)S(0.378)RPIS(0.153)PGLS(0.101)Y(0.101)AS(0.036)HT(0.01)VGFT(0.002)PPT(0.002)S(0.002)LT(0.002)R 54.919 0.0031873 7577100.0 542.53 503.83 405.29 405.66 482.41 396.76 370.11 353.97 222.44 355.08 True False 555.1698934203869 444.8413493757878 350.25384409861374 334.8190961812986 438.77610067640285 392.7689546292567 342.19230472272966 344.5815657433972 377.4644336251935 400.6579767720932 1.3856454272871868 1.1102770321950373 0.8741966075914397 0.8356731067200347 1.0951388119398218 0.9803098338228667 0.8540758566186724 0.8600391998170699 0.9421113655748007 1.0 8.646227389631221 -4.885839369913841 2.632989571311212 0.9275215598867016 1.4268753014833668 0.7695976262227404 0.0769495431659678 0.181542116559805 1.9729219597171184 0.021383396791571217 0.18318959238684313 1.3006505534709875e-05 4.885839369913841 0.49935374159666523 TVSS(ph)PIPYTPSPS(ph)SSRPISPGLSYASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 2 T(0.004)VS(0.031)S(0.228)PIPY(0.192)T(0.22)PS(0.199)PS(0.213)S(0.231)S(0.146)RPIS(0.27)PGLS(0.109)Y(0.113)AS(0.044)HTVGFTPPTSLTR 71.42 3.5211e-06 19147000.0 1235.3 1180.1 1384.2 1644.2 1622.9 1398.2 1345.3 1140.6 631.99 1110.9 True False 1264.0800865246238 1041.9333433863947 1196.2332428663462 1357.071335456519 1476.108981546266 1384.1353774640263 1243.8229378927565 1110.3475828090488 1072.4408712766867 1253.494836082344 1.0084445903864772 0.8312226850832822 0.9543184450643911 1.082630176361868 1.1775947846420154 1.1042210447312129 0.9922840542209046 0.8858014814638682 0.8555606616047012 1.0 10.291740337496293 -7.647896761845038 4.810306671508756 0.9037709436023034 1.0253793865525818 0.22085524189166073 0.09369531752406594 0.34914290157220584 13.128193356880471 0.05313605778880168 0.02951792591978355 2.2495893025843032e-08 7.647896761845038 0.1216084429502784 TVSS(ph)PIPYTPSPSS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPIPYTPSPSSSR 16 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 2 T(0.002)VS(0.138)S(0.86)PIPYTPS(0.039)PS(0.039)S(0.753)S(0.169)R 124.04 0.023999 2680300.0 17080.0 20645.0 17650.0 19204.0 19859.0 18886.0 26465.0 24182.0 16324.0 12992.0 True False 16130.76197665732 22228.405115862242 16514.418215866983 16588.382071252207 17364.134878287434 21487.37506996152 27695.674939402634 24252.365616454386 19589.25613066888 12616.88720273011 1.2785056819059823 1.761797879198947 1.308913835125157 1.3147761254188532 1.376261402616811 1.7030646881991596 2.1951274109361694 1.9222146656907997 1.5526219594346578 1.0 13.62306839675431 -6.826372966314954 5.494328791697247 1.7701010483099717 1.417146941871798 0.1176723904548782 0.3174470027814402 0.3159852873195061 18.147515069777153 0.11021320754485947 0.09805340621651948 1.4915129679498015e-07 6.826372966314954 -0.3529541064381738 TVSS(ph)PIPYTPSPSSSR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSR 16 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 T(0.009)VS(0.042)S(0.943)PIPYT(0.005)PSPSSSR 151.3 0.00020504 4016000.0 1134.3 1901.9 1231.3 948.05 1317.5 1232.6 1503.5 1472.4 845.67 1577.2 True False 1160.726983036412 1679.2246638306774 1064.0962230467646 782.4908646025742 1198.3323576235177 1220.201163111255 1390.0897845252061 1433.3471689707558 1435.0402247069662 1779.6489832289788 0.652222429240175 0.9435707151552479 0.5979247779054037 0.4396883160536692 0.673353211176102 0.6856414802077054 0.781103351068164 0.8054100457327849 0.8063613882459238 1.0 10.797376997711323 -8.317519232202903 0.7597363316370163 0.9890668798854686 0.6650662733891948 0.42337935567958573 0.11882521291439256 0.6893593595992735 0.8893093738283878 0.12465776084698403 0.04916666443340843 4.8137193655741715e-09 8.317519232202903 -0.3240006064962738 TVSS(ph)PIPYTPSPSSSR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPIPYTPSPSSSR 16 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 TVS(0.005)S(0.926)PIPYT(0.021)PS(0.043)PS(0.005)SSR 183.28 8.7762e-07 40311000.0 46751.0 33005.0 52016.0 51443.0 55662.0 35633.0 49776.0 61398.0 54530.0 37614.0 True False 44152.766579081195 35536.37737219826 48669.34719073864 44436.37465587519 48669.24193540637 40541.122305831756 52090.68262927283 61576.658015013934 65437.52369550198 36527.986087091296 1.2087380474196041 0.9728534523494176 1.3323851765246375 1.2165021786289678 1.3323822950262703 1.1098646996079171 1.4260485783441883 1.6857391992047064 1.7914352994847171 1.0 15.15671459472601 -7.45483788103928 4.594674636912621 1.555722229173655 1.2003805463728687 0.2724285412097519 0.21850045574657564 0.23637652448526186 9.634073044089218 0.09322920518499349 0.059780813800570376 3.508828315086426e-08 7.45483788103928 -0.35534168280078626 TVSS(ph)PIPYTPSPSSSRPISPGLSY(ph)ASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 2 T(0.052)VS(0.252)S(0.455)PIPY(0.095)T(0.101)PS(0.094)PS(0.145)S(0.159)S(0.087)RPIS(0.122)PGLS(0.111)Y(0.236)AS(0.087)HT(0.003)VGFTPPTSLTR 57.841 0.00041431 54263000.0 1120.1 1330.3 1431.4 1851.4 1739.6 1298.2 1495.6 1812.2 476.65 1128.0 True False 1146.1961506648024 1174.5478575603086 1237.0237421173867 1528.087745082227 1582.2534871513246 1285.1412866712906 1382.7856878855318 1764.1345691448 808.8402368613941 1272.7897876504487 0.9005384563783024 0.9228137033755642 0.9718994873465433 1.200581399936477 1.2431381069391996 1.009704272567776 1.0864211052778274 1.3860376522987088 0.6354861146038117 1.0 10.313778449889663 -5.581092905186765 6.508023443244007 1.1001882002838903 0.919961639097995 0.11633667321440178 0.18629025290258883 0.36160408093814544 30.65700675193123 0.048554933078378625 0.08525822580331724 2.6236572250890864e-06 5.581092905186765 -0.1802265611858953 TVSS(ph)PIPYTPSPSSSRPISPGLSYAS(ph)HTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 2 T(0.088)VS(0.231)S(0.609)PIPY(0.029)T(0.03)PS(0.018)PS(0.028)S(0.028)S(0.027)RPIS(0.079)PGLS(0.268)Y(0.214)AS(0.29)HT(0.05)VGFT(0.007)PPT(0.002)S(0.001)LT(0.001)R 41.86600000000001 0.025087 31693000.0 11730.0 8652.2 11231.0 16309.0 14729.0 8019.1 7918.5 13052.0 10294.0 12327.0 True False 11078.093558910448 9315.795918792115 10508.409687388223 14087.686065405762 12878.61134106932 9123.658234858012 8286.725940210075 13089.979159125085 12353.08763839165 11971.087480607603 0.9254041102661936 0.7781912824447328 0.8778157961347435 1.1768092153889038 1.075809642351361 0.7621411379407056 0.6922283337778662 1.0934661684103484 1.0319102302445673 1.0 13.547266595457945 -5.540959096909265 24.986938945176178 0.9682832440827865 0.8458490222029335 0.12002328779789029 0.14331000689640327 537.671239820335 743055.5042032761 0.04290948442388034 0.07433758942895954 2.877669429072529e-06 5.540959096909265 -0.12243422187985309 TVSS(ph)PPT(ph)SPRPGSAATVSASTSNIIPPR ddPTM_A459_Selumetinib_30min_R1 4 TVSSPPTSPRPGSAATVSASTSNIIPPR 28 1 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 2 T(0.037)VS(0.142)S(0.735)PPT(0.806)S(0.274)PRPGS(0.004)AATVSAST(0.001)SNIIPPR;T(0.011)VS(0.192)S(0.732)PPT(0.827)S(0.237)PRPGSAATVSASTSNIIPPR;T(0.008)VS(0.054)S(0.861)PPT(0.541)S(0.536)PRPGSAATVSASTSNIIPPR;T(0.002)VS(0.052)S(0.922)PPT(0.514)S(0.51)PRPGSAATVSASTSNIIPPR 106.99 3.498699999999999e-09 317115000.0 36658.0 37535.5 43651.9 41720.3 43112.0 34808.8 37526.8 37197.3 21071.7 30806.8 True False 37512.06007594889 33140.826210219464 37724.2117427232 34434.63279202443 39212.52721204181 34458.65507586166 34696.123263 36210.70677014118 35757.135883923715 34761.15286364348 1.0791373986673085 0.95338685515466 1.085240523831382 0.9906067536683871 1.1280560045249246 0.9912978206169277 0.9981292449966038 1.0417003979178658 1.0286521860821805 1.0 15.085188309891642 -8.575973898604186 17.876585008897035 0.999999998587118 1.0318667088973703 0.03743775021630946 0.050077826245991615 3030.5505383546465 1020361.2107609732 0.045180218472550535 0.011665482262328705 2.65476511038241e-09 8.575973898604186 0.031866710310252344 TVSS(ph)PPT(ph)SPRPGSAATVSASTSNIIPPR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPPTSPRPGSAATVSASTSNIIPPR 28 1 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 2 T(0.022)VS(0.13)S(0.806)PPT(0.519)S(0.519)PRPGS(0.003)AATVSASTSNIIPPR 84.93299999999998 0.00011576 100130000.0 230080.0 230220.0 240830.0 283110.0 292620.0 211480.0 189650.0 202460.0 209520.0 269060.0 True False 217293.0746832154 247877.1337260263 225335.25999587812 244549.92960800987 255858.45954400869 240609.4503756998 198469.10078434565 203049.12508094293 251429.85447793055 261291.53869816472 0.8316116004591527 0.9486611581876202 0.8623901911197281 0.9359274732983444 0.9792068308785454 0.9208466970438098 0.7595695665201411 0.777097972986789 0.9622579274117787 1.0 17.995300881621176 TVSS(ph)PPTSPR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPPTSPR 10 0 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 1 TVS(0.033)S(0.944)PPT(0.022)SPR 108.9 0.010396 20085000.0 220610.0 177220.0 225140.0 205550.0 235490.0 248660.0 235780.0 262010.0 215090.0 174770.0 True False 208349.37937180186 190812.20414788552 210654.73751389736 177553.73540647252 205905.64089268888 282910.65788926324 246744.2371892064 262772.4057219098 258114.01011673434 169723.93599300648 1.2275780558163991 1.1242504071773824 1.2411610435582725 1.0461325585437087 1.2131797420793569 1.6668872085368127 1.4537975197521555 1.5482342203797193 1.52078732210977 1.0 17.37283051547098 -6.617177627939881 7.522362521300638 1.4722904443158666 1.1590651014552475 0.3724721682383183 0.17174346364783202 0.20874597555156446 14.453527015988685 0.05279487109898764 0.05274799686965182 2.414473104645055e-07 6.617177627939881 -0.3132253428606191 TVSS(ph)PPTSPRPGSAATVSASTSNIIPPR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPPTSPRPGSAATVSASTSNIIPPR 28 1 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 1 T(0.029)VS(0.219)S(0.561)PPT(0.137)S(0.046)PRPGS(0.002)AATVSAS(0.001)T(0.003)S(0.001)NIIPPR 50.88 0.013350999999999998 62133000.0 46835.0 34844.0 41773.0 48458.0 42829.0 30009.0 42209.0 45667.0 37074.0 45375.0 True False 44232.09819535981 37516.422758881265 39085.3706590035 41857.93680528743 37448.438123882 34142.46735542067 44171.80213554678 45799.88340942117 44489.83593411041 44064.90585159164 1.0037942290023554 0.8513900582298909 0.8869954423740525 0.94991549389128 0.8498472287676373 0.774822201377458 1.0024258824996735 1.0393732273858214 1.0096432767597396 1.0 15.42734250222697 -7.438518588240786 10.096361291058225 1.0188898462643314 0.8858912977339836 0.5344175424172256 0.058043334064703425 0.3990051937982051 45.90121806831396 0.02465963664370434 0.016601578461043223 3.6431865652973495e-08 7.438518588240786 -0.13299854853034787 TVSSDGCST(ph)PSR ddPTM_A459_Selumetinib_30min_R2 3 TVSSDGCSTPSR 12 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 TVSSDGCS(0.031)T(0.943)PS(0.027)R;TVSS(0.001)DGCS(0.092)T(0.778)PS(0.129)R;TVSSDGCS(0.001)T(0.753)PS(0.246)R 168.98 0.00085625 17871700.0 106486.0 75834.0 92587.0 106097.0 125436.0 91175.0 120954.0 134628.0 109932.0 82103.0 True False 100567.93441723267 81650.2239552578 86630.05322110334 91646.40557246622 109677.60826793198 103733.5286457556 126578.600665804 135019.74519113472 131921.47175671987 79732.47306078757 1.2613171341187457 1.0240523192226603 1.0865090457567659 1.1494238426869756 1.3755701291782887 1.3010198312382681 1.5875413844156223 1.693409723892503 1.6545513602236284 1.0 16.282879797395097 -6.609669231039691 1.3630750866525165 1.5281826369001912 1.1122098358906383 0.3571599890957048 0.1968814798982028 0.38410259590297613 1.4860945260730367 0.08402869323155386 0.08680638107139754 2.456579192248981e-07 6.609669231039691 -0.4159728010095529 TVSSDGCSTPSREEGGCSLAS(ph)TPATTLHLLQLSGQR ddPTM_A459_Selumetinib_30min_R2 1 TVSSDGCSTPSREEGGCSLASTPATTLHLLQLSGQR 36 1 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 T(0.041)VS(0.041)S(0.096)DGCS(0.087)T(0.087)PS(0.087)REEGGCS(0.087)LAS(0.233)T(0.233)PAT(0.006)T(0.003)LHLLQLSGQR 44.287 0.0090939 3355000.0 932.71 1211.1 1070.5 1204.4 2445.6 1255.3 786.31 863.94 1145.4 2140.0 True False 880.8737121339616 1303.9874756997215 1001.625195472273 1040.3586422941137 2138.361864058602 1428.2061805211627 822.8749730437064 866.453922367034 1374.5120051499716 2078.212639612257 0.4238612042597868 0.6274562337100467 0.48196473083675956 0.500602595934658 1.02894276711625 0.6872281273333177 0.39595321352546214 0.416922650671922 0.6613914182556514 1.0 11.021127560857643 -8.551122630318929 21.496270592764702 1.0000000078019382 0.5777892565658704 0.34364546167080146 0.1776962422131855 1652.7733297537875 1257916.7191389275 0.18365064331382466 0.04741839222771251 2.8111069552033764e-09 8.551122630318929 -0.42221075123606777 TVSSPIPYTPSPSSSRPIS(ph)PGLSYASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 TVSSPIPYT(0.001)PS(0.002)PS(0.002)S(0.008)S(0.026)RPIS(0.299)PGLS(0.299)Y(0.266)AS(0.086)HT(0.01)VGFT(0.001)PPTSLTR 61.382 3.1795e-05 134960000.0 3364.0 3672.0 4562.2 4586.5 4430.6 4061.4 4192.4 3976.1 1377.1 2193.5 True False 3442.3746547954606 3242.0805329335117 3942.678298370785 3785.553874267927 4029.8530122859634 4020.546003456154 3876.1638926793935 3870.640911806992 2336.8381205954593 2475.0570914993427 1.3908263638113234 1.3099013126075087 1.592964587326907 1.5294814359109228 1.6281858815001131 1.6244255606324551 1.5660906998841335 1.5638592439345433 0.9441552393362559 1.0 11.2732460885101 -8.261875831542978 24.999968133451652 0.9720775440970715 1.528941833593178 0.838735188401177 0.09709735472578422 15.685588653268836 898319.7545823372 0.0860602289164341 0.027397085402902532 5.471723817332377e-09 8.261875831542978 0.5568642894961064 TVSSPIPYTPSPSSSRPISPGLS(ph)YASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R1 1 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 TVSSPIPYTPS(0.001)PS(0.001)S(0.018)S(0.064)RPIS(0.236)PGLS(0.305)Y(0.268)AS(0.081)HT(0.006)VGFT(0.012)PPT(0.003)S(0.003)LT(0.003)R 74.622 3.8035e-07 102270000.0 2319.2 2474.1 2558.4 2974.9 3701.7 2615.3 2739.6 2896.5 847.07 1427.0 True False 2373.232847622364 2184.431221822114 2210.9833322852605 2455.389560789197 3366.8818885882174 2588.992456502406 2532.9497663353873 2819.6754108420214 1437.415922455012 1610.1693501570828 1.473902634769963 1.3566468779256096 1.37313713745052 1.5249262821638339 2.0910110407080817 1.607900719418012 1.5730952561531997 1.7511669878494105 0.8927110196916755 1.0 10.652996716966632 -8.267141849123224 24.912262455229335 0.9463553911022858 1.592735940855938 0.6251130779309338 0.2006068096571114 335.4675245373063 1465524.9559389695 0.19238886866474447 0.05514431742815998 5.405777307843133e-09 8.267141849123224 0.6463805497536522 TVSSPIPYTPSPSSSRPISPGLS(ph)YASHTVGFTPPTSLTR ddPTM_A459_Selumetinib_30min_R2 2 TVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTR 39 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 TVSSPIPY(0.001)T(0.001)PS(0.002)PS(0.002)S(0.008)S(0.008)RPIS(0.035)PGLS(0.349)Y(0.31)AS(0.209)HT(0.047)VGFT(0.015)PPT(0.004)S(0.004)LT(0.004)R;TVSSPIPYTPSPS(0.001)S(0.013)S(0.013)RPIS(0.134)PGLS(0.417)Y(0.357)AS(0.059)HT(0.004)VGFT(0.001)PPTSLTR 71.891 1.6977e-06 49248000.0 72346.0 53285.0 80149.0 116075.0 117387.0 79299.0 72663.0 75934.0 79464.0 95906.0 True False 68325.29894398418 57371.78816172046 74992.30059963324 100265.38475945649 102639.79560690516 90221.71744534998 76041.97347900296 76154.95536844963 95359.02040967105 93136.94458628626 0.7336003907738732 0.615993883163825 0.8051831733663647 1.0765371916035544 1.1020309509060073 0.9686995621996651 0.8164533828845357 0.8176664556340073 1.0238581567524598 1.0 16.507065934001915 -5.539176738650516 5.388745443847097 0.962942793331252 0.6809991944824973 0.625776881539016 0.09337369815392028 0.11915010927721058 10.607283435397203 0.028622007315929412 0.053140384052886104 2.889503742807965e-06 5.539176738650516 -0.28194359884875464 TVSSPPT(ph)S(ph)PRPGSAATVSASTSNIIPPR ddPTM_A459_Selumetinib_30min_R2 1 TVSSPPTSPRPGSAATVSASTSNIIPPR 28 1 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 2 TVS(0.006)S(0.09)PPT(0.952)S(0.952)PRPGSAATVSASTSNIIPPR 105.61 4.125600000000001e-09 98138000.0 215180.0 215350.0 248470.0 227950.0 287530.0 207120.0 211120.0 212110.0 187870.0 198790.0 True False 203221.15703378932 231866.6525406119 232483.7107136816 196902.8167643166 251407.91084918595 235648.89995183883 220937.49832634363 212727.20498329928 225449.24952638813 193050.4161815519 1.0526843767209104 1.2010678719415748 1.2042642295836603 1.019955411953848 1.3022914729836814 1.2206598908868744 1.1444549185460737 1.101925648185304 1.167825762749805 1.0 17.558618138907796 -9.444147264522133 0.778476469089479 0.9963997850976645 1.1646289450267904 0.2599293165776577 0.07910744325083024 6.287675110469178 4.199906528248947 0.1474069911512393 0.027123468905465593 3.596273687597424e-10 9.444147264522133 0.1682291599291259 TVSSPPT(ph)SPRPGSAATVSASTSNIIPPR ddPTM_A459_Selumetinib_30min_R1 2 TVSSPPTSPRPGSAATVSASTSNIIPPR 28 1 O76094-2;O76094 O76094-2 SRP72 Signal recognition particle subunit SRP72 1 T(0.023)VS(0.08)S(0.255)PPT(0.297)S(0.297)PRPGS(0.032)AAT(0.001)VS(0.002)AS(0.003)T(0.007)S(0.003)NIIPPR;T(0.064)VS(0.072)S(0.213)PPT(0.492)S(0.147)PRPGS(0.001)AATVSAS(0.001)T(0.007)S(0.003)NIIPPR 62.532 0.0032101 223340000.0 1630.53 1336.06 1851.95 1893.62 1922.61 1707.27 1971.6 1805.73 882.9599999999999 1490.72 True False 1668.5181765409172 1179.6334740825564 1600.4653620331815 1562.9348146497823 1748.710264964365 1690.0964138771317 1822.880624655733 1757.83617456232 1498.318631153124 1682.068432842444 0.9919442895205941 0.7012993354195182 0.9514864739056035 0.9291743332990657 1.0396189779326077 1.004772683963352 1.0837137116801707 1.0450443871607766 0.8907596158981413 1.0 10.71602068568564 -5.785403895048305 1.9399162140697825 1.0144684919160623 0.8490305089257085 0.3271197370236272 0.08449486438623624 0.3323530322194377 2.5537166114854357 0.025005230360460276 0.04880726677131099 1.6390647295096936e-06 5.785403895048305 -0.16543798299035373 TVSTSS(ph)QPEENVDR ddPTM_A459_Selumetinib_30min_R1 1 TVSTSSQPEENVDR 14 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 TVST(0.031)S(0.331)S(0.637)QPEENVDR 212.39 1.7409e-39 0.0 1647.8 1917.8 1750.9 2060.0 1810.4 1741.2 1813.2 1892.3 1065.8 1497.8 True False 1686.1905339393475 1693.263084438969 1513.137397005263 1700.2596709891907 1646.649639652081 1723.6851088831081 1676.4288641843048 1842.1100569433313 1808.5847570478836 1690.057219807485 0.9977120976598781 1.0018968970955013 0.8953172586533047 1.0060367489704685 0.9743159109368211 1.0198974855297822 0.9919361572712121 1.089969046819117 1.0701322628910164 1.0 10.722856376929922 -7.25649468187257 1.355642659313696 1.0557863293463186 0.9734691522896136 0.3738434668794477 0.03949723958944418 0.4294900326597858 1.5405350359831178 0.024253903873187044 0.014188019868371165 5.539943278018822e-08 7.25649468187257 -0.08231717705670494 TVSTSS(ph)QPEENVDR ddPTM_A459_Selumetinib_30min_R2 1 TVSTSSQPEENVDR 14 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 TVSTS(0.227)S(0.773)QPEENVDR 165.78 0.00024489 13624000.0 37689.0 28686.0 42444.0 47559.0 52219.0 29089.0 31087.0 37510.0 29459.0 29224.0 True False 35594.39626102095 30886.123959972112 39713.199249533056 41081.3821561489 45658.78237621692 33095.745706349175 32532.60709772188 37619.14788988519 35351.62315323295 28380.22718692922 1.254197016344333 1.088297276710914 1.3993263333643553 1.4475353521859515 1.608823709390371 1.1661550659323732 1.1463124267273335 1.3255407591384978 1.2456427117508935 1.0 14.79259851793115 TVT(ph)NAVVTVPAYFNDSQR ddPTM_A459_Selumetinib_30min_R2 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 T(0.255)VT(0.605)NAVVT(0.14)VPAYFNDSQR 129.36 0.0015152000000000002 0.0 5664.7 5886.3 5012.7 5344.5 5222.9 3903.4 4795.7 6039.1 4479.6 4643.4 True False 5349.878651590795 6337.76028256236 4690.188339415099 4616.5698802232555 4566.752608681579 4441.057918462768 5018.709552499271 6056.672781173173 5375.645170481762 4509.332976997921 1.1864013322769669 1.4054762233996103 1.0401068990335645 1.02378110105693 1.012733508919513 0.9848591667806693 1.1129605150250994 1.3431416158594236 1.1921153744695487 1.0 12.138698329684535 -5.271404227410609 24.96181262867173 1.0930917986547335 1.2959387825129776 0.34324461094521663 0.11453011875339174 740.3696283189563 1854617.8307692206 0.03307069662500338 0.0701893922208352 5.352981871408697e-06 5.271404227410609 0.20284698385824407 TVT(ph)PASSAKTS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 TVTPASSAKTSPAK 14 1 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 2 T(0.04)VT(0.96)PASSAKT(0.316)S(0.684)PAK;T(0.047)VT(0.953)PASS(0.001)AKT(0.124)S(0.875)PAK 151.11 0.029236 10943000.0 3388.1 2170.6000000000004 13365.5 12816.2 5912.3 4527.9 3476.0 3223.2 3081.6000000000004 2167.5 True False 3467.0361379050246 1916.4651429154371 11550.538511436307 10578.091259869743 5377.533508901345 4482.353437004265 3213.8025214563454 3137.710265570861 5229.25012884102 2445.719738237897 1.4175933913028684 0.7835996549204858 4.72275638571666 4.325144494066639 2.198752958004818 1.832733884804696 1.3140518397139975 1.2829394212729919 2.1381232064670717 1.0 11.256043375600067 -6.676840134829783 3.2967368476629666 1.499605852462958 2.8391900522231754 0.22189932424642433 1.1367332153640737 0.42083850196850614 9.115883054360548 0.44486050736013083 0.4346645619238019 2.1045529898019392e-07 6.676840134829783 1.3395841997602174 TVT(ph)PASSAKTS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 TVTPASSAKTSPAK 14 1 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 2 T(0.009)VT(0.991)PASS(0.001)AKT(0.262)S(0.737)PAK 173.51 0.0098697 6085200.0 26494.0 66031.0 39821.0 61176.0 38551.0 15125.0 7927.9 12095.0 4672.3 41446.0 True False 25021.56954388521 71095.36537687072 37258.960213826605 52843.72326551367 33707.87872968725 17208.331458920253 8296.563058835825 12130.194447564965 5606.89055496963 40249.346290359616 0.6216639983014653 1.7663731694916802 0.925703487083733 1.3129088578059867 0.8374764272323311 0.42754312914249576 0.20612913807305708 0.3013761853436697 0.13930389116189382 1.0 15.296677731439685 -6.612036196754848 2.621662623005489 0.34877659237232966 1.182955456010256 0.4934236490183712 0.3516619316170184 0.2038430116916329 2.8438516020542646 0.11820049320978519 0.1196296641682286 2.443226910753425e-07 6.612036196754848 0.8341788636379264 TVTAMDVVYALKR ddPTM_A459_Selumetinib_30min_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 0 109.16 0.010568 0.0 1089.1 1023.5 1471.7 1855.7 1177.2 1087.0 910.01 1405.9 657.81 910.22 False True 1114.4739109803031 903.668144187759 1271.8512234694422 1531.636830803225 1070.722467851541 1076.0657669170325 841.3672130467455 1368.610964993197 1116.2555254584993 1027.0556032936088 1.0851154576308792 0.879862922016914 1.2383469983424575 1.491289104398537 1.0425165535516279 1.047719094726961 0.8192031768763159 1.3325578095326807 1.0868501392513124 1.0 10.004298573839566 TVTCVTVVEPEAPPS(ph)PDVLQAATHR ddPTM_A459_Selumetinib_30min_R1 4 TVTCVTVVEPEAPPSPDVLQAATHR 25 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 TVTCVTVVEPEAPPS(1)PDVLQAATHR;TVTCVTVVEPEAPPS(1)PDVLQAATHR;TVTCVTVVEPEAPPS(1)PDVLQAATHR;TVTCVTVVEPEAPPS(1)PDVLQAATHR 218.22 9.9732e-35 785083000.0 8183.0 9386.8 10205.5 10149.5 8720.599999999999 8261.8 9255.9 8396.4 4446.62 6296.2 True False 8373.64797865377 8287.789092195067 8819.649154798792 8377.080354711063 7931.823269746978 8178.693793114208 8557.720011032152 8173.700196649038 7545.589371724769 7104.378600181524 1.178660154519329 1.1665748066950297 1.2414385059058424 1.1791432898152443 1.1164696754117682 1.1512187417637392 1.204569814285164 1.1505158517931733 1.062104062349939 1.0 12.794492751210774 -8.371268304712144 2.2359016748890608 1.001715475980934 1.1761654711687506 0.785452815832323 0.030861600030163888 0.13729408805970464 1.3539550858029703 0.03165694187704994 0.008882855603499794 4.2533556200679395e-09 8.371268304712144 0.17444999518781668 TVTCVTVVEPEAPPS(ph)PDVLQAATHR ddPTM_A459_Selumetinib_30min_R2 5 TVTCVTVVEPEAPPSPDVLQAATHR 25 0 A0A0J9YX88;E9PJ24;B7ZM65;F8WEF5;A0A0J9YYB5;A0A0J9YWD5;Q9P1Y6-2;Q9P1Y6-3;Q9P1Y6 A0A0J9YX88 PHRF1 PHD and RING finger domain-containing protein 1 1 TVTCVTVVEPEAPPS(1)PDVLQAATHR;TVTCVTVVEPEAPPS(1)PDVLQAATHR;TVTCVTVVEPEAPPS(1)PDVLQAATHR;TVTCVTVVEPEAPPS(0.886)PDVLQAAT(0.114)HR;TVTCVTVVEPEAPPS(1)PDVLQAATHR 205.73 4.973099999999998e-32 342123000.0 140847.7 135787.09999999998 156303.1 158240.3 167178.1 119758.7 114044.7 129932.6 109815.09999999999 148213.6 True False 133019.94869201625 146201.53394565755 146246.72871594806 136687.69816025646 146175.6924868232 136254.3738637617 119348.00452528583 130310.68235450018 131781.18849026077 143934.28826282042 0.9241713722106656 1.0157519497973768 1.016065945655042 0.9496534829190119 1.015572413293975 0.9466429125974806 0.829183969752637 0.905348433144409 0.915564943424958 1.0 17.13505078864253 -7.002536836010983 23.394760242113314 0.9022476656608405 0.9853666338763376 0.32529866484911085 0.04783218650032555 43.35028886416209 399785.1617478972 0.016347447903148397 0.014145220083707133 9.941757463288174e-08 7.002536836010983 0.08311896821549714 TVTLELLDNGAGADAT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 TVTLELLDNGAGADATK 17 0 A8K7I4 A8K7I4 CLCA1 Calcium-activated chloride channel regulator 1 1 TVTLELLDNGAGADAT(1)K 112.24 0.0045447 9293400.0 33156.0 25887.0 33565.0 38242.0 38054.0 24466.0 26544.0 25721.0 25738.0 33660.0 True False 31313.322253984225 27872.449660175622 31405.4644428088 33033.37362887038 33273.31631292361 27835.96941976482 27778.348595938176 25795.84385165923 30886.319179806156 32688.148340817068 0.9579411451361983 0.8526775322226443 0.960759970719828 1.0105611760095397 1.0179015331797139 0.8515615240587542 0.8497987804727343 0.7891497426744252 0.9448782126713184 1.0 14.996480035786444 -6.7796577892158805 24.99953933405522 0.8715695656438123 0.9568623858198363 0.20376433214143153 0.06856824408422835 347.0039490447184 476160.4197081508 0.02461236749841775 0.021747860494720526 1.6608951265711993e-07 6.7796577892158805 0.08529282017602402 TVTNAVVT(ph)VPAYFNDSQR ddPTM_A459_Selumetinib_30min_R2 2 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 T(0.016)VT(0.02)NAVVT(0.816)VPAY(0.014)FNDS(0.134)QR;TVTNAVVT(0.998)VPAYFNDS(0.002)QR 127.91 0.0016132000000000002 2441100.0 15718.8 14408.2 21432.6 16462.7 20780.3 14773.7 14411.9 15023.2 15293.2 14475.5 True False 14845.212023341985 15513.262610335014 20053.649850050464 14220.451860258481 18169.692935760933 16808.643072704133 15082.08190663808 15066.915024775355 18352.26732771044 14057.55470313421 1.056030891349273 1.1035534229062076 1.4265389872948095 1.0115878728957002 1.2925215885313182 1.1957017722973222 1.0728808975059827 1.0718019842680109 1.3055092237072141 1.0 13.779058040498015 -10.410240863082747 5.422748740055449 0.9999998425596386 1.1700872484702196 0.1397155726507957 0.12705101322362117 2.3370637218240176e-07 4.803509432354181e-08 0.11891599709850247 0.028841339037489387 3.8882943736627443e-11 10.410240863082747 0.17008740591058102 TVTNAVVTVPAYFNDSQR ddPTM_A459_Selumetinib_30min_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 127.3 0.010179 18425000.0 2467.7 2844.6 2811.3 2956.2 2808.2 2571.5 2701.6 2823.0 1371.1 2228.5 False True 2525.192608691666 2511.5529095813386 2429.5409013655244 2439.9551647467215 2554.1988058279785 2545.63304473519 2497.816136929363 2748.1248696036673 2326.6565588181224 2514.549682428213 1.0042325376737735 0.9988082268297118 0.9661932386316588 0.970334840388018 1.015767882287964 1.0123614031268457 0.9933453112436851 1.0928894699546754 0.9252776252849183 1.0 11.296084343103523 -6.274860550038074 23.95166168818622 1.010876064335349 0.9845505708359538 0.06134805226776163 0.03954084390143266 1141.971664668156 2037978.5158903007 0.011691783430235445 0.013344732654512479 5.310549361564687e-07 6.274860550038074 -0.02632549349939517 TVTNAVVTVPAYFNDSQR ddPTM_A459_Selumetinib_30min_R2 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PN89;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 141.65 0.0042668 5684100.0 18287.0 16150.0 15655.0 20305.0 20202.0 17569.0 16708.0 16593.0 17021.0 13867.0 False True 17270.68174866115 17388.653069565273 14647.774343875228 17539.42397192128 17664.044151828526 19988.97027449719 17484.955106273923 16641.282882880983 20425.67560647605 13466.623679207074 1.2824804613295664 1.2912407358953637 1.0877094877531843 1.3024366307200481 1.3116906340155932 1.48433421402878 1.2983919000626185 1.2357427725982788 1.5167629313065298 1.0 13.717100566516223 -5.978645518594934 24.87895824809846 1.3260620156922587 1.2221398860936417 0.06337689092839549 0.14260103369447547 529.7694606977303 617201.2363239239 0.03823672505337614 0.056709264589406144 1.0503994396595148e-06 5.978645518594934 -0.10392212959861702 TVTPAS(ph)SAK ddPTM_A459_Selumetinib_30min_R2 1 TVTPASSAK 9 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 T(0.042)VT(0.439)PAS(0.462)S(0.057)AK 89.9 0.029256 10641000.0 71474.0 50238.0 43370.0 62633.0 65656.0 55554.0 106090.0 148070.0 85106.0 91541.0 True False 67501.76121309174 54091.09305936965 40579.62141768567 54102.27735204853 57407.70630791274 63206.059230998704 111023.39521334686 148500.85918569184 102129.5780603226 88897.97347791844 0.7593172101933083 0.6084626110493447 0.45647408855462074 0.6085884214839511 0.6457706971483705 0.7109955014519943 1.2488855580147078 1.6704639417070435 1.1488403398272153 1.0 16.439862911240255 -7.248100827818687 3.6209607406200393 1.335023436122096 0.6127241987574592 0.7579060889414131 0.17548401046631865 0.10247795605083303 2.9441534217721017 0.07259288899218186 0.05122366185623638 5.6480583165128124e-08 7.248100827818687 -0.7222992373646369 TVTPASS(ph)AK ddPTM_A459_Selumetinib_30min_R2 1 TVTPASSAK 9 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 1 T(0.009)VT(0.05)PAS(0.243)S(0.697)AK 90.913 0.027914 11125000.0 75753.0 56201.0 49605.0 62949.0 65193.0 65187.0 121870.0 169180.0 98780.0 102870.0 True False 71542.95152328581 60511.43598530263 46413.46830584035 54375.23760691811 57002.8725071853 74165.91754133119 127537.19648082356 169672.28579074336 118538.76014380476 99899.87581164138 0.71614655115466 0.6057208329207072 0.46459985989724095 0.5442973493724979 0.5706000337243935 0.7424024998906815 1.2766502004596245 1.698423390542107 1.1865756506775496 1.0 16.608195264113284 -7.2107025944667305 3.1802619219123853 1.3608287225272389 0.579059862276239 0.7836894010178179 0.1763383359679201 0.10458529642952902 2.1224712761492346 0.07333501952292226 0.052519379062512986 6.15598291061775e-08 7.2107025944667305 -0.7817688602509999 TVVLT(ph)PTYSGEADALLPSLR ddPTM_A459_Selumetinib_30min_R1 1 TVVLTPTYSGEADALLPSLR 20 0 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 T(0.189)VVLT(0.733)PT(0.074)YS(0.003)GEADALLPSLR 117.65 0.00061241 6510000.0 1254.8 1520.9 1555.5 1775.9 1556.1 1287.5 1469.5 1425.1 961.96 1005.9 True False 1284.0343985842287 1342.8323209527719 1344.271643749892 1465.7724027717009 1415.351029751769 1274.548918956468 1358.6544318987624 1387.3017186228087 1632.375861221413 1135.0170632957324 1.1312908326292441 1.1830943907165672 1.1843624974646199 1.291410015031456 1.246986565683898 1.1229337074947392 1.197034367002076 1.2222738877550625 1.4381949963655234 1.0 10.148498271118447 -5.007504572292069 1.803466958789797 1.2220038076605868 1.1258600420627747 0.05002255633881891 0.10630802500727014 1.720001654812273 8.02150889221688 0.028892815605212528 0.24399866536081738 9.828685252157377e-06 5.007504572292069 -0.09614376559781213 TVVLT(ph)PTYSGEADALLPSLR ddPTM_A459_Selumetinib_30min_R2 2 TVVLTPTYSGEADALLPSLR 20 0 Q96Q42-3;Q96Q42 Q96Q42-3 ALS2 Alsin 1 T(0.001)VVLT(0.98)PT(0.018)YS(0.001)GEADALLPSLR;T(0.301)VVLT(0.582)PT(0.11)YS(0.007)GEADALLPSLR 139.9 0.00016902 3230900.0 30312.0 24493.0 25821.0 31953.0 33626.0 25915.0 22385.0 23862.0 23505.0 29204.0 True False 28627.380388550184 26371.534342592087 24159.704971779116 27600.946278000527 29401.601259745894 29484.55601705247 23425.946855036018 23931.434469433232 28206.656784573122 28360.80463889547 1.0093994424011905 0.929858467641105 0.851869517786715 0.9732074470181697 1.0366984164977824 1.0396233954736187 0.8259972575992596 0.8438207157427553 0.9945647573725415 1.0 14.791610844146502 -8.482253774445203 24.97296457403485 1.0000006462018725 0.9383457450405307 0.09021268769456803 0.07436512098196647 1152.2567945769356 708315.9454759428 0.07778042147068451 0.02008281843206026 3.294171652048484e-09 8.482253774445203 -0.06165490116134176 TWSAPYDGERPS(ph)PEPSPFGSR ddPTM_A459_Selumetinib_30min_R2 2 TWSAPYDGERPSPEPSPFGSR 21 1 Q8N612;Q8N612-2;E9PJK5;Q8N612-3 Q8N612 FAM160A2 FTS and Hook-interacting protein 1 TWSAPY(0.001)DGERPS(0.99)PEPS(0.009)PFGSR;TWSAPYDGERPS(0.997)PEPS(0.002)PFGSR 80.835 0.0010452 17903600.0 57306.0 50149.0 56747.0 67374.0 70464.0 41312.6 47118.0 46949.0 40213.0 48744.0 True False 54121.16193409398 53995.26704554979 53095.95980146199 58197.54497336735 61611.682363847365 47003.0356515563 49309.08036254576 47085.613817174635 48256.723645098464 47336.634067878396 1.143325101157106 1.140665535452378 1.1216674114455414 1.2294398644803293 1.3015644981326566 0.9929526375736025 1.0416684948878911 0.9946971250565934 1.0194371567674352 1.0 15.530669504586442 -6.784425708384839 24.999978091809588 1.0114144240229839 1.1834311286445356 0.7586309544799443 0.05005471841776292 129.56302383440936 140911.97738424334 0.019266299379127255 0.01700240077483085 1.6427606508205468e-07 6.784425708384839 0.17201670462155172 TWTTPEVT(ph)SPPPSPR ddPTM_A459_Selumetinib_30min_R1 1 TWTTPEVTSPPPSPR 15 0 Q5T1S5;Q7Z6M1-2;Q7Z6M1 Q5T1S5 RABEPK Rab9 effector protein with kelch motifs 1 TWT(0.002)T(0.013)PEVT(0.673)S(0.304)PPPS(0.009)PR 115.12 0.0056396 10258000.0 3770.1 3904.3 4387.1 4774.6 4555.0 3963.0 4406.0 3505.4 2222.4 3544.6 True False 3857.935994662415 3447.1827409401717 3791.355916615336 3940.805740342231 4143.001054250566 3923.135818116103 4073.6518727090483 3412.4254048560733 3771.250482326156 3999.5839373278186 0.9645843305491318 0.861885334813922 0.9479375795144325 0.9853039221312458 1.0358580090254503 0.980885982039724 1.0185189101021133 0.8531950968719925 0.9429106980677057 1.0 11.965634213968636 -5.513458179400925 19.5716405452806 0.9719892298327776 0.9111539007920958 0.1744076589027186 0.052464347944171895 42.999624717177056 89327.68437872734 0.01479453832544444 0.027729431329249384 3.0657858865600817e-06 5.513458179400925 -0.060835329040681785 TWTTPEVT(ph)SPPPSPR ddPTM_A459_Selumetinib_30min_R2 1 TWTTPEVTSPPPSPR 15 0 Q5T1S5;Q7Z6M1-2;Q7Z6M1 Q5T1S5 RABEPK Rab9 effector protein with kelch motifs 1 T(0.002)WT(0.023)T(0.088)PEVT(0.799)S(0.087)PPPSPR 160.87 0.00029306 4608600.0 17279.0 18991.0 20784.0 24160.0 24969.0 17702.0 13456.0 18467.0 16252.0 19442.0 True False 16318.70235331745 20447.548634310464 19446.780067908185 20869.36632167536 21832.170994307824 20140.289817243385 14081.73066255816 18520.735912623564 19502.8541188208 18880.6589436175 0.8643078825823446 1.0829891422419153 1.0299841825426361 1.105330401020253 1.1563246314392044 1.0667154084710424 0.745828347655123 0.9809369454705601 1.03295410277053 1.0 14.204621495843476 TWTTPEVTS(ph)PPPSPR ddPTM_A459_Selumetinib_30min_R1 1 TWTTPEVTSPPPSPR 15 0 Q5T1S5;Q7Z6M1-2;Q7Z6M1 Q5T1S5 RABEPK Rab9 effector protein with kelch motifs 1 TWT(0.002)T(0.004)PEVT(0.227)S(0.754)PPPS(0.013)PR 137.73 0.00040048 12852000.0 3256.4 3662.3 4127.9 3791.1 3458.2 3135.7 3356.8 3019.4 1988.7 2736.2 True False 3332.2677841486156 3233.5162134429215 3567.353852931649 3129.0555527607385 3145.4064205947984 3104.157704987803 3103.593873424814 2939.3157036065586 3374.6786510988245 3087.4179228449966 1.0793057070414342 1.0473205423590009 1.1554489680633844 1.0134862305513124 1.018782198976278 1.0054219359222287 1.0052393135571718 0.9520303946729815 1.0930423853953413 1.0 11.592185068686224 -5.874474071998597 10.85194566560223 1.0099510372172071 1.0892863170099016 0.4526879056973627 0.04088837662023822 0.3048235928855999 27.751560980276928 0.01103529730093148 0.0163812087065457 1.3351372967882572e-06 5.874474071998597 0.0793352797926945 TWTTPEVTS(ph)PPPSPR ddPTM_A459_Selumetinib_30min_R2 1 TWTTPEVTSPPPSPR 15 0 Q5T1S5;Q7Z6M1-2;Q7Z6M1 Q5T1S5 RABEPK Rab9 effector protein with kelch motifs 1 T(0.001)WT(0.001)T(0.014)PEVT(0.222)S(0.76)PPPS(0.002)PR 91.845 0.014115 5034600.0 23215.0 26880.0 22613.0 29575.0 31630.0 19594.0 19214.0 18317.0 18153.0 25428.0 True False 21924.803237008196 28941.609567177384 21158.10419917283 25546.83398027931 27656.35662421228 22292.89564337742 20107.489071818716 18370.29943745741 21784.107237198743 24693.827570121703 0.8878657297962229 1.1720179662303662 0.8568175240995478 1.0345433047078414 1.1199704276576017 0.9027719813817242 0.8142718667132742 0.7439227226031396 0.8821681116602768 1.0 14.591862852662459 -6.966605086879263 7.701791993970731 0.8413822225863757 1.015423324805449 0.31695345798793617 0.10691840826147343 0.21829812694811865 41.32869779318242 0.03647222649806174 0.03192783448182981 1.0799282774189587e-07 6.966605086879263 0.1740411022190732 TYAGGTAS(ph)ATK ddPTM_A459_Selumetinib_30min_R2 2 TYAGGTASATK 11 0 P20810-6;P20810-7;P20810-10;P20810-9;A0A0C4DGB5;H0YA91;H0Y944;P20810-5;F8W7E0;E9PSG1;D6RGF7;D6RBR1;E7EN75 P20810-6;P20810-5 CAST Calpastatin 1 T(0.014)YAGGT(0.054)AS(0.818)AT(0.115)K;T(0.005)YAGGT(0.014)AS(0.904)AT(0.077)K 105.95 0.0114 9111400.0 30613.0 27766.0 33244.0 30046.0 31529.0 23944.0 24208.0 24540.0 20877.3 27589.0 True False 28911.652013548646 29895.562918238345 31105.11723333045 25953.682967758985 27568.045147163743 27242.068658009037 25333.719967241985 24611.407337184297 25053.343360500683 26792.43388516941 1.079097633961217 1.1158210951035186 1.1609664641385293 0.9686944858759284 1.0289488915161107 1.016782154796639 0.9455550054101328 0.9185954304363372 0.9350902373363185 1.0 14.709538024356823 -6.219388265932682 0.869750725599676 0.9470338723035531 1.1215447957759046 0.6536661034146071 0.045054134871640984 0.3834621103882315 0.6172604824215836 0.023344061346202316 0.040584968475577514 6.034089313170061e-07 6.219388265932682 0.17451092347235153 TYDATTHFETTCDDIK ddPTM_A459_Selumetinib_30min_R2 2 TYDATTHFETTCDDIK 16 0 P50395-2;P50395 P50395-2 GDI2 Rab GDP dissociation inhibitor beta 0 ; 116.86 0.0026517 14620000.0 174303.0 213830.0 217095.0 246948.0 228948.0 148558.0 156120.0 141879.0 110139.0 212883.0 False True 164615.9370501935 230230.07342818167 203127.34405516373 213313.25639093883 200185.5054189112 169020.51602474548 163379.88934591136 142291.84440066724 132169.87754078262 206736.5146535398 0.7962596125124086 1.1136401027850045 0.9825421715925485 1.0318121921926597 0.9683122778498654 0.8175648907886406 0.7902807572223619 0.6882763049339764 0.639315593388425 1.0 17.657433700438062 -6.852611402370155 2.4035720684166058 0.7546713900041044 0.993193603444948 0.40115896298476306 0.11579760354576106 0.25497335578669456 3.006591609543424 0.04398503520520835 0.038413889731076484 1.4040694746941916e-07 6.852611402370155 0.23852221344084357 TYGGDT(ph)GSPEISFTK ddPTM_A459_Selumetinib_30min_R1 3 TYGGDTGSPEISFTK 15 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 T(0.002)YGGDT(0.848)GS(0.113)PEIS(0.036)FT(0.001)K;T(0.001)YGGDT(0.995)GS(0.003)PEISFTK;T(0.003)YGGDT(0.545)GS(0.45)PEIS(0.002)FTK 214.89 5.255600000000001e-07 28330500.0 8075.4 10778.8 10495.900000000001 10995.599999999999 10480.4 9437.4 10062.1 9084.3 5290.23 7524.9 True False 8263.54110800692 9516.813085071824 9070.614429851812 9075.424872975123 9532.4496704649 9342.468324473599 9303.10769595682 8843.35485403493 8977.133926888182 8490.794213733036 0.9732353534892466 1.120838975190248 1.0682881013864374 1.0688546494621791 1.1226805679787983 1.1003055885352944 1.0956699057562773 1.0415226928632495 1.0572784713553107 1.0 13.051683791870785 -8.556978489941265 1.2165620874460026 1.001782081663434 1.0806701883308352 0.2298495818285966 0.041081922505191694 0.7246763799191244 2.339987981546439 0.03783624808692638 0.011751169888765926 2.7734574671055488e-09 8.556978489941265 0.0788881066674012 TYGGDTGS(ph)PEISFTK ddPTM_A459_Selumetinib_30min_R2 1 TYGGDTGSPEISFTK 15 0 H0Y9X0;A0A286YEZ9;A0A2C9F2R7;O94915 H0Y9X0 FRYL Protein furry homolog-like 1 T(0.003)YGGDT(0.12)GS(0.433)PEIS(0.252)FT(0.193)K 173.51 3.1841e-05 5904500.0 57110.0 52233.0 63098.0 66587.0 68657.0 47859.0 49972.0 59468.0 48272.0 60414.0 True False 53936.05482944376 56239.10314443361 59038.343375907985 57517.735731018096 60031.69385863237 54451.14282925388 52295.79701763946 59641.042034542654 57927.748832372476 58669.69084557701 0.9193171815308772 0.9585716633902012 1.0062835260424552 0.9803654135899412 1.023214763763461 0.9280966380506986 0.8913596827241835 1.0165562690882812 0.987353913025426 1.0 15.840327769432802 TYQVPPVQPAS(ph)PGSHNALK ddPTM_A459_Selumetinib_30min_R2 1 TYQVPPVQPASPGSHNALK 19 0 A2RRE0;Q9Y4E6-2;Q9Y4E6;K7EPQ4 A2RRE0 WDR7 WD repeat-containing protein 7 1 TYQVPPVQPAS(1)PGSHNALK 143.48 4.9525e-05 4630300.0 27970.0 27741.0 26342.0 30418.0 27733.0 23592.0 22172.0 23529.0 19914.0 27889.0 True False 26415.539372781343 29868.645498626025 24647.18439900105 26275.015926023218 24248.932603834313 26841.583853146883 23203.041932984524 23597.46549456436 23897.35644364985 27083.772105675784 0.9753271911206783 1.1028244286683624 0.9100351421815386 0.9701387171440908 0.8953306987379579 0.9910578093928746 0.8567138226702921 0.8712769182406161 0.8823496354350812 1.0 14.725141064517237 -5.278981295738188 24.557380568141706 0.9184009281200959 1.0390758085867973 0.4152345637990791 0.05538040774234741 508.122504629123 711333.6871338581 0.014189567744719933 0.02965170476818053 5.260399214714179e-06 5.278981295738188 0.12067488046670138 TYS(ph)APAINAIQGGSFESPK ddPTM_A459_Selumetinib_30min_R1 2 TYSAPAINAIQGGSFESPK 19 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 T(0.014)YS(0.986)APAINAIQGGSFESPK;T(0.168)YS(0.832)APAINAIQGGSFESPK 181.54 3.8055e-13 24886000.0 4502.2 6158.1 4054.3 4802.3 4031.6000000000004 5349.3 4520.6 4386.6 2190.8 4305.4 True False 4607.092500243798 5437.106789176978 3503.7483286757883 3963.6684553356267 3666.94249183679 5295.4908987757935 4179.607502444059 4270.25311831507 3717.627590298839 4858.040028147376 0.948343873980125 1.1191976100803003 0.7212267310222124 0.8158986818491037 0.754819324375799 1.090046781849025 0.8603485105572424 0.8790073967224064 0.7652525645649249 1.0 12.246158661867607 -5.2506064511884185 24.960139258809185 0.8592828788056648 1.03377073683124 0.2709219207036063 0.11346145858956194 922.6443685520186 2125854.1280489773 0.028805791080664542 0.07457953270690554 5.615566167031722e-06 5.2506064511884185 0.17448785802557532 TYS(ph)APAINAIQGGSFESPK ddPTM_A459_Selumetinib_30min_R2 3 TYSAPAINAIQGGSFESPK 19 0 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 T(0.092)YS(0.908)APAINAIQGGSFESPK;T(0.135)YS(0.864)APAINAIQGGS(0.001)FESPK;T(0.127)YS(0.873)APAINAIQGGSFESPK 228.68 1.4807999999999998e-23 13762500.0 127064.0 95263.0 106715.0 117537.0 112635.0 103958.4 127231.0 126399.0 110083.0 107067.0 True False 120002.29155749326 102569.36578117633 99849.0730825069 101528.25783736553 98484.78433032412 118277.72595960431 133147.49360344379 126766.80016351919 132102.6759760119 103975.69751652564 1.1541378843688006 0.9864744188407507 0.9603116446190432 0.9764614257214179 0.9471904174018279 1.1375516470164149 1.280563600761434 1.2191964390849235 1.2705149292700424 1.0 16.665886837711604 -6.933288596357997 4.7904617905418325 1.211037412331716 1.0008253749193734 0.48927237758626296 0.09061830358525197 0.15424664511189534 6.903591212283513 0.03178956844857887 0.027676606600637973 1.1660345090158004e-07 6.933288596357997 -0.21021203741234262 TYS(ph)DEANQMR ddPTM_A459_Selumetinib_30min_R1 2 TYSDEANQMR 10 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 T(0.493)YS(0.507)DEANQMR;T(0.288)YS(0.712)DEANQMR 130.56 0.0027575 71433000.0 6290.2 7117.0 8069.3 8234.2 7322.9 6931.4 7541.4 7154.7 3815.96 5599.700000000001 True False 6436.749421401432 6283.738331396461 6973.5333814921305 6796.251545077277 6660.544987962998 6861.676409207658 6972.546126384031 6964.934114259075 6475.405413308727 6318.476040697003 1.0187186561985258 0.9945022013098099 1.1036733124531826 1.0756156233406513 1.0541378878487069 1.0859701556216923 1.1035170635251592 1.1023123407287243 1.0248365858477502 1.0 12.625360920018597 -5.252153265597238 24.97293785352126 1.0739907851642057 1.0066104220421186 0.345746407905256 0.03358457749891421 631.1412909321047 1697302.771296305 0.008186655172756581 0.021046289575107385 5.595600939277148e-06 5.252153265597238 -0.06738036312208706 TYS(ph)DEANQMR ddPTM_A459_Selumetinib_30min_R2 1 TYSDEANQMR 10 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 T(0.1)YS(0.9)DEANQMR 144.28 0.00099767 142170000.0 24729.0 24285.0 29186.0 36302.0 38349.0 19387.0 22283.0 21581.0 30061.0 26315.0 True False 23354.661178030387 26147.5814114175 27308.204535314097 31357.604975557064 33531.25577559017 22057.383272336327 23319.203652926855 21643.797137073132 36074.03997451834 25555.217575418927 0.913890132576871 1.0231797610116362 1.0685960491129347 1.2270529445900449 1.3121099703664134 0.8631264127272742 0.912502645853313 0.8469423933956988 1.411611537567861 1.0 14.641330253949269 -9.24929304947419 15.585643947915733 1.0000027742933923 1.0585454623136474 0.009856144347837215 0.185449525297783 0.0 0.0 0.18354819797204744 0.04451697691944312 5.632574575714535e-10 9.24929304947419 0.058542688020255085 TYS(ph)FEQPWPNAR ddPTM_A459_Selumetinib_30min_R1 2 TYSFEQPWPNAR 12 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 T(0.13)YS(0.87)FEQPWPNAR;T(0.028)YS(0.972)FEQPWPNAR 174.72 0.00013142 64051000.0 3789.0 4198.3 3952.2 4719.1 4302.0 3635.5 3893.6 3613.5 2387.1000000000004 3825.2 True False 3877.276327889421 3706.7610842632794 3415.5129478806316 3894.997773478201 3912.884859579791 3598.930170769893 3599.9026172446547 3517.6582416977863 4050.7343531140955 4316.201680603274 0.8983074969164775 0.8588016405538275 0.7913237611740251 0.9024132933783109 0.9065574662935788 0.8338188150343502 0.8340441164791672 0.814989312827042 0.9384951521885153 1.0 12.075546563020973 -8.488029626291075 4.359506370727551 0.9995730480545716 0.8553105296750402 0.6280122977489712 0.036646906703413674 0.11652235409812754 5.4148786643998825 0.036906814657914525 0.009644711160809994 3.2506512164339245e-09 8.488029626291075 -0.1442625183795314 TYS(ph)GPMNK ddPTM_A459_Selumetinib_30min_R1 1 TYSGPMNK 8 0 Q8WVV4-3;Q8WVV4;Q8WVV4-1 Q8WVV4-3 POF1B Protein POF1B 1 T(0.001)YS(0.999)GPMNK 84.615 0.036427 13966000.0 2619.6 3153.3 2699.5 3512.3 2995.9 2616.7 2965.4 2662.2 1697.4 2394.2 True False 2680.631583145716 2784.1101700706017 2332.922727292081 2898.9427390365704 2724.9213739691045 2590.3783737735057 2741.717490542763 2591.5898079556814 2880.363826809043 2701.518891482894 0.9922683093562552 1.03057216399563 0.8635596569941117 1.0730788328655025 1.0086627128760757 0.9588599887049533 1.0148799992428716 0.959308415767964 1.066201623053607 1.0 11.399555055301647 -8.25834059585642 24.979593615119537 1.0331008093418597 0.9884394537217197 0.10040212019763628 0.05437976408294195 596.6129518933925 4809482.534105001 0.038636334139231655 0.013274528600752343 5.516446417622071e-09 8.25834059585642 -0.04466135562013995 TYS(ph)LGSALRPSTSR ddPTM_A459_Selumetinib_30min_R2 1 TYSLGSALRPSTSR 14 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 TYS(0.572)LGS(0.168)ALRPS(0.236)T(0.024)SR 176.43 0.00032885 31750000.0 106350.0 103310.0 117510.0 115670.0 100590.0 89779.0 65276.0 69376.0 66403.0 100740.0 True False 100439.49275278146 111233.54480599286 109949.53453521417 99915.54645812047 87952.9849139902 102145.24231738196 68311.46334194003 69577.87267418498 79685.45545483989 97831.37444604615 1.026659323979688 1.1369925592462977 1.1238678303129757 1.0213037179930835 0.8990263646198301 1.0440949326917093 0.6982572178786438 0.7112020358311236 0.8145184089055837 1.0 16.578009590114682 -6.676986376517321 1.1433670131424458 0.7939838610906125 1.093160470313382 0.5304834659802808 0.10364745458093226 0.3395138735262331 0.9431924377549286 0.052013120990627146 0.050972608247485035 2.1038444347073912e-07 6.676986376517321 0.29917660922276945 TYS(ph)LTTPAR ddPTM_A459_Selumetinib_30min_R1 4 TYSLTTPAR 9 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 T(0.002)YS(0.92)LT(0.076)T(0.001)PAR;T(0.05)YS(0.948)LT(0.002)TPAR;T(0.031)YS(0.968)LT(0.001)TPAR;T(0.009)YS(0.99)LTTPAR 117.02 0.0076638 164527000.0 14662.899999999998 16400.7 16403.5 17275.1 16991.1 13351.999999999998 16905.1 14950.5 7826.799999999999 12293.900000000001 True False 15004.517040963248 14480.498419521424 14175.994797975804 14258.328078789016 15454.258005022353 13217.691002646021 15629.934696625907 14553.964173931869 13281.507953145412 13871.941817726825 1.081645038460954 1.0438696045435347 1.021918559365671 1.027853797697481 1.1140659475138153 0.9528363927936359 1.126730121997236 1.0491656009783354 0.957436826628922 1.0 13.759882132223204 -8.24896440429662 23.35559863231973 0.9787184199346158 1.0513843287829716 0.2765404053152244 0.047563120189972635 349.2051192282112 653787.698375966 0.030979616810570054 0.011498034632811795 5.6368385466539495e-09 8.24896440429662 0.07266590884835578 TYS(ph)LTTPAR ddPTM_A459_Selumetinib_30min_R2 3 TYSLTTPAR 9 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 T(0.008)YS(0.852)LT(0.14)TPAR;T(0.001)YS(0.996)LT(0.002)TPAR;T(0.008)YS(0.991)LT(0.001)TPAR 115.23 0.0082322 169218000.0 160465.0 146485.0 171615.0 182800.0 182993.0 129550.0 142090.0 152495.0 128283.0 163566.0 True False 151546.99769229032 157719.9284764872 160573.47774028374 157902.32465241087 160003.78336182336 147394.33656218968 148697.46654599346 152938.73520309362 153943.18452650064 158843.42458449467 0.9540652884355114 0.9929270216192686 1.010891562935731 0.9940752981463 1.0073050475986902 0.9279221783825569 0.9361260432086429 0.9628269826286695 0.9691505010622117 1.0 17.277245844527975 -6.748609153322834 24.999915123294077 0.9554393802616523 0.9930936978437177 0.32376784394890334 0.02324082562043176 247.4886165511374 482235.1606119554 0.007763895894049618 0.007715689977694036 1.783983555014256e-07 6.748609153322834 0.03765431758206539 TYS(ph)MICLAIDDDDKTDK ddPTM_A459_Selumetinib_30min_R1 2 TYSMICLAIDDDDKTDK 17 1 Q8IUC4-2;Q8IUC4 Q8IUC4-2 RHPN2 Rhophilin-2 1 T(0.344)YS(0.656)MICLAIDDDDKTDK;T(0.185)YS(0.815)MICLAIDDDDKTDK 216.16 5.9061e-12 67514000.0 4698.7 4004.2 4243.5 3802.7 2926.6000000000004 4359.7 2916.1000000000004 3560.1000000000004 3415.6 3878.2 True False 4808.170567921354 3535.386402497923 3667.256007876994 3138.629830519709 2661.8895467331954 4315.845376290883 2696.136229234421 3465.6745831654343 5796.023734446194 4376.004746866994 1.09875807867068 0.8079027805052286 0.8380374839635562 0.7172363861732132 0.6082921981835094 0.9862524439400616 0.6161182140318114 0.7919723089072718 1.3245012447931792 1.0 12.095398587755481 -8.245136969183125 24.33612640030334 1.1622505969891297 0.7989182807279394 0.4389001080023607 0.15991683073244653 431.59954741156986 644292.1807544691 0.10562058511656489 0.03963318952192409 5.686735524745501e-09 8.245136969183125 -0.36333231626119034 TYS(ph)SPGSFK ddPTM_A459_Selumetinib_30min_R2 1 TYSSPGSFK 9 0 Q8N3Z6 Q8N3Z6 ZCCHC7 Zinc finger CCHC domain-containing protein 7 1 TYS(0.7)S(0.298)PGS(0.002)FK 137.46 0.0025514 21214000.0 82890.0 88497.0 91348.0 89082.0 96737.0 72264.0 73570.0 80050.0 63715.0 88913.0 True False 78283.30563496053 95284.43533729526 85470.76913218222 76948.8779249785 84584.03322024728 82217.7100527215 76991.15077618937 80282.93224700903 76459.78034584466 86345.85066628232 0.9066249858087254 1.1035207204751463 0.9898653898554756 0.8911705349036153 0.9795958064870508 0.9521906312613022 0.891660110845999 0.9297833263267526 0.8855061332518885 1.0 16.397839230528795 -5.5773034397323435 7.424520302728064 0.9313801262527295 1.0152850047082846 0.224936373562603 0.0568937983168289 0.2561846271889205 29.21683617829811 0.014635918450927848 0.025551841869068576 2.6466502889884626e-06 5.5773034397323435 0.08390487845555517 TYS(ph)SSGSSGGSHPSSR ddPTM_A459_Selumetinib_30min_R1 6 TYSSSGSSGGSHPSSR 16 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9 H0Y6B5 ABI2 Abl interactor 2 1 T(0.011)YS(0.452)S(0.056)S(0.056)GS(0.213)S(0.213)GGSHPSSR;T(0.055)YS(0.781)S(0.146)S(0.003)GS(0.007)S(0.007)GGSHPSSR;T(0.029)YS(0.636)S(0.156)S(0.156)GS(0.008)S(0.008)GGS(0.006)HPSSR;T(0.051)YS(0.931)S(0.014)S(0.002)GS(0.001)S(0.001)GGSHPSSR;T(0.012)YS(0.89)S(0.096)S(0.002)GSSGGSHPSSR;T(0.021)YS(0.574)S(0.118)S(0.274)GS(0.002)S(0.002)GGS(0.009)HPS(0.001)SR 164.66 2.2971e-05 4631710.0 823.98 755.4839999999999 913.06 959.77 964.231 648.6279999999999 1196.21 798.752 53.971 376.44 True False 843.1771308140208 667.0315820650171 789.0714670795737 792.1641866142219 877.0164762988098 642.1033912271029 1105.9789166258045 777.5665022478461 91.58484511412213 424.7597408361126 1.9850683804314413 1.570373832397599 1.857688926747946 1.8649700300101346 2.0647354068265944 1.5116860886183872 2.6037752882341323 1.8306031092241835 0.21561564411411302 1.0 8.730503222280904 -8.245900589983941 21.2473983604437 0.6078086507592417 1.9113317103075336 0.7112044713403425 0.3322033028369944 48.61934464013429 66482.74747516803 0.2178014718413294 0.08124405929752763 5.676745312501303e-09 8.245900589983941 1.3035230595482918 TYS(ph)SSGSSGGSHPSSR ddPTM_A459_Selumetinib_30min_R2 2 TYSSSGSSGGSHPSSR 16 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9 H0Y6B5 ABI2 Abl interactor 2 1 T(0.008)YS(0.483)S(0.483)S(0.027)GSSGGSHPSSR;T(0.317)YS(0.682)S(0.001)SGSSGGSHPSSR 253.79 8.843699999999999e-30 7224600.0 3451.55 3555.9 6641.3 11472.5 12457.5 9055.6 6224.1 10817.5 11752.9 15461.1 True False 3259.7266686493917 3828.6260959793904 6214.005988500709 9909.925708833627 10892.477478536972 10302.926701447825 6513.532982820173 10848.977134066465 14103.808403463505 15014.697870237882 0.2171023817342884 0.2549918838905503 0.4138615403522774 0.6600149929408218 0.725454323002265 0.6861894119008731 0.43381045953187586 0.7225571388666632 0.9393334801241695 1.0 13.874087824441519 -5.910885979184749 0.2780048836446785 0.9706996319329657 2.304974017308821e-18 0.74969088975489 0.127019392693491 2.8249770277826105 0.3034530722789778 0.2028835899989646 0.9084370771849181 1.227761528588249e-06 5.910885979184749 -0.9706996319329657 down TYSAPAINAIQGGSFES(ph)PKK ddPTM_A459_Selumetinib_30min_R1 1 TYSAPAINAIQGGSFESPKK 20 1 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 TYSAPAINAIQGGS(0.01)FES(0.99)PKK 113.52 0.00015456 20276000.0 1839.4 2634.6 2615.2 2675.1 1552.2 2072.8 2212.5 2286.2 1377.9 2331.6 True False 1882.254441150647 2326.1398072076904 2260.0702042653274 2207.9440028462054 1411.8037840631678 2051.949513951818 2045.6093437060306 2225.562549375809 2338.195662165773 2630.8835717072584 0.7154457389876802 0.8841667613965103 0.8590536763277217 0.839240484296082 0.5366272378017117 0.7799469106191754 0.7775370091267756 0.8459373015627504 0.8887491971560141 1.0 11.361331688910008 -8.38651044670098 1.3380342838772163 0.9955418537489974 0.7719085623962008 0.38715904585804206 0.09193433802920618 0.47697754998162983 1.799868104753708 0.09299460444152564 0.02864974818944947 4.106667614060962e-09 8.38651044670098 -0.22363329135279664 TYSAPAINAIQGGSFES(ph)PKK ddPTM_A459_Selumetinib_30min_R2 2 TYSAPAINAIQGGSFESPKK 20 1 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 TYSAPAINAIQGGS(0.04)FES(0.96)PKK;TYSAPAINAIQGGS(0.028)FES(0.972)PKK 109.42 0.00020542 21590000.0 85305.0 69448.0 78734.0 67436.0 58016.0 70267.0 84683.0 70708.0 47901.0 72264.0 True False 80564.08960297158 74774.43828948402 73668.3401590974 58251.100466411306 50727.51141037939 79945.64142968261 88620.9272961812 70913.74857366043 57482.53846576635 70177.55055557951 1.1480037271914485 1.0655036788476089 1.0497422548362276 0.8300532008491427 0.722845283267674 1.139191105941592 1.2628102091707352 1.010490506041499 0.819101521935296 1.0 16.098721973014968 -5.225946430494662 2.494228018226681 0.9785694577486301 1.1264551327506858 0.11796010569698778 0.15009582687948908 0.8028467161899532 9.431568866476884 0.045803669428945364 0.16305431125709807 5.943654680906545e-06 5.225946430494662 0.14788567500205563 TYSAPAINAIQGGSFES(ph)PKKEK ddPTM_A459_Selumetinib_30min_R1 1 TYSAPAINAIQGGSFESPKKEK 22 2 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 TYSAPAINAIQGGS(0.218)FES(0.781)PKKEK 53.033 0.013452 17401000.0 4212.1 4314.0 5958.7 6619.6 4298.2 4974.5 3557.7 4052.8 2868.7 3928.7 True False 4310.233734680134 3808.9148744758086 5149.541268796198 5463.611125281579 3909.4285689088433 4924.461046484618 3289.3398246792963 3945.3065786502843 4867.974378441796 4432.986913778648 0.9723091492291639 0.8592208703880687 1.1616414325046505 1.232489793348935 0.8818949040335589 1.1108674900840256 0.7420143322452277 0.8899883206033044 1.0981251407061718 1.0 12.114063388321476 -7.199577036651191 24.999992842668245 0.923359811446048 1.0359325958735603 0.11885180852178112 0.13764879966798496 498.65689496575027 201518.4695383078 0.0544525347790715 0.042178745704565306 6.315721389092125e-08 7.199577036651191 0.1125727844275124 TYSAPAINAIQGGSFES(ph)PKKEK ddPTM_A459_Selumetinib_30min_R2 1 TYSAPAINAIQGGSFESPKKEK 22 2 Q9H4L5;Q9H4L5-5;Q9H4L5-3;Q9H4L5-7 Q9H4L5 OSBPL3 Oxysterol-binding protein-related protein 3 1 TYSAPAINAIQGGS(0.046)FES(0.954)PKKEK 62.362 0.004352 4458400.0 32188.0 26012.0 23306.0 24790.0 20418.0 21121.0 24177.0 20384.0 14244.0 26066.0 True False 30399.11981877318 28007.036758237264 21806.517333654163 21413.55923486473 17852.90830076404 24030.226032651553 25301.278405816633 20443.314065247134 17093.198010613043 25313.40685239863 1.2009098576113881 1.1064111963097292 0.8614611798722713 0.845937465459559 0.705274813653633 0.9493082528468314 0.9995208686585445 0.8076081652877151 0.6752626428470389 1.0 14.627614067886832 -5.175572582369412 2.93052988738296 0.8493337800576057 1.1895828992194095 0.5732111798632673 0.10423129498797636 0.1975551510612705 3.2054153654252473 0.028721441866565472 0.10033284768143216 6.674633404418621e-06 5.175572582369412 0.3402491191618038 TYSLGS(ph)ALRPSTSR ddPTM_A459_Selumetinib_30min_R1 1 TYSLGSALRPSTSR 14 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 TYS(0.018)LGS(0.982)ALRPSTSR 71.286 0.030345 70521000.0 1074.2 1309.5 1269.2 1564.8 1183.2 1220.4 1186.9 1150.2 676.82 1058.4 True False 1099.226769970656 1156.1831312299666 1096.8496112165626 1291.5370549339254 1076.1797689109271 1208.1238840345422 1097.3711774213286 1119.6929596238533 1148.5141070230331 1194.2559496890376 0.9204281295453245 0.9681200512595441 0.9184376360043776 1.0814575010241465 0.9011299204254705 1.0116121961536935 0.9188743650027986 0.9375653183184064 0.9616984594651466 1.0 10.221896348882183 -5.994141012175515 0.0027557911289457027 1.9171101943480031 5.9534804075862455e-08 0.028630699620794786 0.052152871314826314 370549.9583759344 254.11903773805676 87298.8641660315 89485.73626318359 1.0135822297204745e-06 5.994141012175515 -1.9171101348131991 TYSLGSALRPS(ph)TSR ddPTM_A459_Selumetinib_30min_R1 1 TYSLGSALRPSTSR 14 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 TYSLGSALRPS(0.888)T(0.095)S(0.017)R 108.25 0.0027192 40268000.0 859.27 1550.2 1562.9 1853.4 1669.3 1421.0 1536.2 1187.1 716.9 1203.1 True False 879.2893191516338 1368.701863331572 1350.6667643951819 1529.738482626877 1518.312109738852 1406.706030164769 1420.3231971982852 1155.6142517557612 1216.526939695654 1357.5296041863955 0.647712813363371 1.0082298456775625 0.9949446113218822 1.1268546025879789 1.118437568548509 1.0362249381720454 1.0462557816921596 0.8512626525359293 0.8961328990130949 1.0 10.40676794445762 -4.761358593629395 7.769980084691671 1.0131037007426587 0.642585137361963 0.6394518291651361 0.0812676666719608 0.06912352420217158 33.374678077806465 0.022807977837383604 0.13456124000460795 1.732372999927893e-05 4.761358593629395 -0.37051856338069566 TYSLGSALRPS(ph)TSR ddPTM_A459_Selumetinib_30min_R2 4 TYSLGSALRPSTSR 14 1 P08670;B0YJC4;A0A1B0GTT5;A0A1B0GVG8 P08670 VIM Vimentin 1 TYSLGSALRPS(0.685)T(0.302)S(0.013)R;TYSLGSALRPS(0.661)T(0.218)S(0.12)R;TYS(0.108)LGS(0.108)ALRPS(0.532)T(0.227)S(0.024)R;TYSLGSALRPS(0.709)T(0.242)S(0.049)R 161.04 0.0013584 99960000.0 311169.0 312754.0 367233.0 336128.0 316294.0 253771.0 221241.0 243566.0 205444.0 323257.0 True False 293875.4726882014 336741.22613738856 343605.62859305786 290346.7865468576 276558.32001576375 288725.6517462252 231529.14488072458 244274.7367354783 246538.54058497483 313923.73048744857 0.9361365330103685 1.0726848384940821 1.094551304100268 0.9248959487580579 0.8809729662244226 0.9197318447315315 0.7375331088261952 0.7781340275110071 0.7853453455148465 1.0 18.260054565359162 -6.291055836842126 1.3615012481217876 0.8191427396422453 1.0362724048909715 0.4805401833056262 0.08313495639073766 0.3283227574322439 1.2309515608669508 0.03231600257400182 0.04425855546150829 5.116160533061672e-07 6.291055836842126 0.21712966524872623 TYSS(ph)PGSFK ddPTM_A459_Selumetinib_30min_R2 2 TYSSPGSFK 9 0 Q8N3Z6 Q8N3Z6 ZCCHC7 Zinc finger CCHC domain-containing protein 7 1 T(0.014)YS(0.043)S(0.938)PGS(0.005)FK;TYS(0.065)S(0.93)PGS(0.005)FK 164.66 0.00097838 23999000.0 192171.0 181037.0 185051.0 195190.0 192459.0 151736.0 151670.0 155573.0 132524.0 174957.0 True False 181490.90514146443 194921.9557742968 173145.02012829442 168604.78527846874 168280.57981470978 172636.25667773368 158722.9555284033 156025.69167350332 159032.50302994106 169905.53681712225 1.068187114683685 1.1472372203155508 1.0190663787175986 0.9923442663316289 0.9904361150739809 1.0160719886577365 0.934183538110619 0.9183084589023223 0.9360054181231046 1.0 17.374373341723214 -5.622747709690705 0.7481093500191237 0.949397138387078 1.1328810949245334 0.6728790928326294 0.03713376548743266 0.6402280887234981 0.5677819142038201 0.018222477102124622 0.08238760409322911 2.3837038082152683e-06 5.622747709690705 0.18348395653745542 TYSS(ph)SGSSGGSHPSSR ddPTM_A459_Selumetinib_30min_R1 1 TYSSSGSSGGSHPSSR 16 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9 H0Y6B5 ABI2 Abl interactor 2 1 T(0.015)Y(0.001)S(0.164)S(0.442)S(0.353)GS(0.019)S(0.006)GGSHPSSR 71.969 0.025503 1218900.0 142.23 119.05 157.05 51.44600000000001 259.96 0.0 0.0 139.09 0.0 0.0 True False 145.5436822685965 105.1115706551565 135.72347261389945 42.46192186102425 236.44666389966574 0.0 0.0 135.4008813720064 0.0 0.0 0.0 TYSSS(ph)GSSGGSHPSSR ddPTM_A459_Selumetinib_30min_R1 1 TYSSSGSSGGSHPSSR 16 0 H0Y6B5;B7Z836;E7EW77;E7EP65;A0A0C4DG21;F8WAL6;Q9NYB9-3;Q9NYB9-2;Q9NYB9-4;Q9NYB9 H0Y6B5 ABI2 Abl interactor 2 1 T(0.01)YS(0.137)S(0.332)S(0.522)GSSGGSHPSSR 214.34 8.828899999999999e-09 845280.0 0.0 69.527 66.242 0.0 0.0 0.0 0.0 160.29 0.0 0.0 True False 0.0 61.3867465177746 57.246700241260285 0.0 0.0 0.0 0.0 156.0385885047014 0.0 0.0 0.0 TYSTS(ph)FTPMYHAVTK ddPTM_A459_Selumetinib_30min_R2 1 TYSTSFTPMYHAVTK 15 0 P00390-5;P00390-4;P00390-2;P00390-3;P00390 P00390-5 GSR Glutathione reductase, mitochondrial 1 T(0.01)Y(0.001)S(0.01)T(0.033)S(0.473)FT(0.473)PMYHAVTK 86.213 0.013175999999999998 3749000.0 42886.0 38048.0 47064.0 46736.0 52726.0 38016.0 43816.0 39680.0 41754.0 38400.0 True False 40502.56780626033 40966.159256397514 44035.95347940876 40370.476175903124 46102.088503579405 43252.35892511158 45853.530819756896 39795.4622306224 50105.96670423601 37291.29222481806 1.086113282481134 1.0985449098793567 1.1808642407436338 1.0825711249833228 1.2362695351409032 1.1598514383560652 1.2296042342356939 1.067151601792382 1.3436371794831379 1.0 15.186551170065014 -5.06969657359632 0.9343518338729285 1.1733212147859948 1.0558981362749318 0.07585681514242282 0.09267690256827027 3.474840825829752 3.2514884557952075 0.03069451274406527 0.3774311763742277 8.51732906439455e-06 5.06969657359632 -0.11742307851106304 TYSTSFT(ph)PMYHAVTK ddPTM_A459_Selumetinib_30min_R2 1 TYSTSFTPMYHAVTK 15 0 P00390-5;P00390-4;P00390-2;P00390-3;P00390 P00390-5 GSR Glutathione reductase, mitochondrial 1 T(0.059)Y(0.003)S(0.059)T(0.059)S(0.213)FT(0.607)PMYHAVTK 80.459 0.039509 4397300.0 41374.0 34028.0 39424.0 52210.0 51079.0 39570.0 37642.0 31886.0 30212.0 35510.0 True False 39074.59871324475 36637.83818273481 36887.5027616057 45098.90793272639 44661.99936794622 45020.4083193041 39392.42758620795 31978.782980988537 36255.24419381085 34484.73403393983 1.133098450890982 1.0624364435194977 1.06967630155712 1.3077934105085487 1.2951237879343926 1.3055170521250092 1.1423149602208902 0.9273315824189063 1.0513418534163115 1.0 15.073670219477467 -7.619011706492739 5.5252612170779365 0.9940619326432617 1.1957575426515539 0.5060280945508673 0.08951278136410917 0.19666843774814888 9.197057776420579 0.04957195725968667 0.028042729169611584 2.4042979908106665e-08 7.619011706492739 0.20169561000829217 TYSYLT(ph)PDLWK ddPTM_A459_Selumetinib_30min_R1 1 TYSYLTPDLWK 11 0 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 T(0.088)YS(0.254)YLT(0.657)PDLWK 121.36 0.010438 8738500.0 949.36 2065.8 2045.9 2166.4 1553.1 1725.5 2057.4 1710.6 719.34 1186.5 True False 971.478240867009 1823.9351756356343 1768.078017324272 1788.0789083645557 1412.6223792220756 1708.1430366286481 1902.2086615777569 1665.2293311881099 1220.6674414851045 1338.798832488703 0.7256342157552684 1.3623668704917435 1.3206450247925439 1.3355844544924518 1.0551416276604764 1.2758772977515735 1.420832327767815 1.2438234115371931 0.9117631505668382 1.0 10.386723482684816 -8.257093964371691 24.128927952985354 0.955881554004102 1.2330054538025808 0.22757457756710486 0.19108256790087744 292.3713937527849 1623499.097628948 0.1372313149300436 0.04768678104420884 5.532303988048416e-09 8.257093964371691 0.27712389979847873 TYT(ph)HEVVTLWYR ddPTM_A459_Selumetinib_30min_R1 1 TYTHEVVTLWYR 12 0 G3V5T9;P24941;Q00526;K7EJ83 G3V5T9 CDK2;CDK3 Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 T(0.13)YT(0.869)HEVVTLWYR 108.36 0.010974 48299000.0 2083.7 3267.5 2263.4 2908.4 1659.3 2315.6 2074.8 1581.1 1429.8 1829.7 True False 2132.2461558255945 2884.939580980463 1956.0427119662534 2400.502537429595 1509.2166079732083 2292.3071663965784 1918.296165568937 1539.164091863393 2426.2661715397494 2064.5598177872566 1.0327848762022707 1.3973630389031153 0.9474381391684213 1.1627188114134632 0.7310113250149123 1.1103127875720336 0.9291550426593688 0.7455168305624733 1.1751978076082874 1.0 11.011618503890551 -5.609965901802508 1.8125512081059938 0.9513825922091593 1.2034251272317733 0.19312574140168626 0.17228183877563322 0.4993297841184724 3.261144863407714 0.049073437563133725 0.12125208607461664 2.4549016522700486e-06 5.609965901802508 0.252042535022614 TYT(ph)HEVVTLWYR ddPTM_A459_Selumetinib_30min_R2 1 TYTHEVVTLWYR 12 0 G3V5T9;P24941;Q00526;K7EJ83 G3V5T9 CDK2;CDK3 Cyclin-dependent kinase 2;Cyclin-dependent kinase 3 1 T(0.006)YT(0.994)HEVVTLWYR 132.51 0.00254 4701200.0 36012.0 36310.0 38905.0 39105.0 39471.0 31516.0 28073.0 32912.0 25849.0 38609.0 True False 34010.597207458064 39094.860244948286 36401.894656561235 33778.83154011234 34512.30010478288 35857.04292623674 29378.450125594183 33007.768471125084 31019.52228140529 37494.25785177084 0.9070881557894807 1.042689267234072 0.970865853658762 0.9009067914786578 0.9204689486380346 0.9563342490467037 0.7835453162385144 0.8803419606708162 0.8273139424185256 1.0 15.194382047075532 -6.288355347482342 1.0135206917848993 0.8719969920960786 0.9790740412420327 0.2058714973870296 0.06588650262493703 0.7008742757675169 1.5204071845320295 0.029719036448420517 0.044702866091364535 5.148072477463235e-07 6.288355347482342 0.10707704914595406 VAAAAGSGPS(ph)PPGS(ph)PGHDR ddPTM_A459_Selumetinib_30min_R2 1 VAAAAGSGPSPPGSPGHDR 19 0 Q9BTU6 Q9BTU6 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 2 VAAAAGS(0.007)GPS(0.993)PPGS(1)PGHDR 99.957 0.0052534 7028800.0 36082.0 17713.0 29480.0 36096.0 28723.0 24400.0 40220.0 31997.0 28707.0 25808.0 True False 34076.706887690256 19071.530143728156 27583.28889539711 31179.66253092688 25114.559953122 27760.878518853155 42090.30969441804 32090.105972611495 34449.20214059738 25062.855982763132 1.3596497905556477 0.760948000373322 1.100564473353212 1.2440586400995381 1.002062972009033 1.1076502429709358 1.6793899994224708 1.2803850444929867 1.3745122329350519 1.0 14.613263202724776 -7.039437563882514 24.78947061996294 1.3621634595794854 1.080856697981178 0.22573954894185344 0.21258742560773528 611.4879934872157 384364.24035151006 0.0772786658586925 0.059871279115087564 9.131927105257217e-08 7.039437563882514 -0.28130676159830736 VAAAAGSGPS(ph)PPGSPGHDR ddPTM_A459_Selumetinib_30min_R2 6 VAAAAGSGPSPPGSPGHDR 19 0 Q9BTU6 Q9BTU6 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 1 VAAAAGSGPS(1)PPGSPGHDR;VAAAAGS(0.039)GPS(0.961)PPGSPGHDR;VAAAAGSGPS(0.999)PPGSPGHDR;VAAAAGS(0.001)GPS(0.996)PPGS(0.003)PGHDR;VAAAAGS(0.001)GPS(0.841)PPGS(0.158)PGHDR;VAAAAGS(0.141)GPS(0.789)PPGS(0.07)PGHDR 139.16 9.0274e-05 46501500.0 108174.2 49931.1 98222.70000000001 144353.3 117225.2 82308.2 121092.6 96779.2 112489.7 92332.40000000001 True False 102162.31101963254 53760.6548162087 91903.15841878997 124692.13151666799 102498.32236941528 93645.40743055198 126723.6458404347 97060.81144934102 134990.78322482872 89666.52370361418 1.1393584450460268 0.599562162060731 1.0249439213520624 1.3906207842831988 1.1431057894941443 1.0443742387079675 1.4132771139796834 1.082464307082631 1.505475819170044 1.0 16.452281846286574 -5.5279091155278675 14.015385102836536 1.2245077742433632 0.8551513457855389 0.34564445698212254 0.19948043700026172 0.5718522275122815 1586.915082753381 0.05007089732072521 0.08858821762417464 2.965451902433299e-06 5.5279091155278675 -0.36935642845782435 VAAETQS(ph)PSLFGSTK ddPTM_A459_Selumetinib_30min_R1 1 VAAETQSPSLFGSTK 15 0 Q9UKX7-2;Q9UKX7 Q9UKX7-2 NUP50 Nuclear pore complex protein Nup50 1 VAAET(0.002)QS(0.499)PS(0.499)LFGSTK 197.15 2.9228e-05 4673500.0 1589.7 2066.3 1299.4 1417.3 1577.6 1359.6 1694.1 1791.6 918.04 1423.5 True False 1626.736916982266 1824.3766354031914 1122.9486170932882 1169.7951610160105 1434.9063585479012 1345.9236584180294 1566.3126730722645 1744.08094806303 1557.8468290112958 1606.2200910641973 1.0127733590385333 1.1358198328813425 0.699124997464875 0.7282907040721708 0.8933435501962919 0.837944728686771 0.9751544522360618 1.0858293690670333 0.9698837896985513 1.0 10.649453875233135 -7.449660369837788 5.017857221197364 1.0229517609333652 0.8815416674031155 0.20239720373374592 0.12169843772580466 0.3763500154302884 17.481137889073327 0.05870273423090388 0.038162637833107874 3.5509097153194794e-08 7.449660369837788 -0.1414100935302497 VAAETQSPS(ph)LFGSTK ddPTM_A459_Selumetinib_30min_R2 1 VAAETQSPSLFGSTK 15 0 Q9UKX7-2;Q9UKX7 Q9UKX7-2 NUP50 Nuclear pore complex protein Nup50 1 VAAETQS(0.044)PS(0.92)LFGS(0.018)T(0.018)K 120.32 0.0018057 12762000.0 23664.0 21764.0 24130.0 28243.0 25843.0 21351.0 25623.0 27393.0 24882.0 27694.0 True False 22348.8496144976 23433.22881771014 22577.502070757546 24396.254678107478 22596.371300648698 24291.906444919416 26814.520271011294 27472.709094844733 29859.095261167793 26894.402262346634 0.8309851766360686 0.8713050615189805 0.8394870371358675 0.9071127307507899 0.8401886414960271 0.9032328068852146 0.9970297911604015 1.0215028698855952 1.110234574834625 1.0 14.715018304422934 -7.324774054318935 1.7255191569467208 1.0525147041555565 0.8589544103180399 0.8653099436634598 0.03302071982337558 0.12024755804704132 0.6968620035057818 0.0177631048881671 0.010365667668409361 4.733974842815585e-08 7.324774054318935 -0.1935602938375166 VAALAASPAS(ph)VAVDSGSELNSR ddPTM_A459_Selumetinib_30min_R1 1 VAALAASPASVAVDSGSELNSR 22 0 O15119;O15119-2 O15119 TBX3 T-box transcription factor TBX3 1 VAALAAS(0.404)PAS(0.593)VAVDSGS(0.003)ELNSR 159.4 3.5201e-11 0.0 853.19 848.15 863.14 794.92 969.4 748.13 685.64 581.89 296.1 989.79 True False 873.067666981255 748.8482037057627 745.9303288886415 656.1021444964699 881.7179411614708 740.604491447691 633.9216227880693 566.4563869548981 502.4600737116519 1116.8391878710438 0.7817308673109203 0.6705067406644659 0.667894122080869 0.5874633981523819 0.7894761848769213 0.6631254521606249 0.5676033126993617 0.5071960163169921 0.44989473790712703 1.0 10.125205753775129 -7.117085879850658 5.111089271732663 0.5909961190758005 0.6929525571734516 0.0156583408181048 0.14978891784011247 0.5773642754280798 21.90399092430542 0.055312621599090096 0.042705096691544056 7.636847532968291e-08 7.117085879850658 0.10195643809765109 VAASGAQDPEKS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 1 VAASGAQDPEKSPDR 15 1 Q1MSJ5;Q1MSJ5-1;Q1MSJ5-2 Q1MSJ5 CSPP1 Centrosome and spindle pole-associated protein 1 1 VAAS(0.015)GAQDPEKS(0.985)PDR 69.92 0.029259 8189000.0 46864.0 30618.0 42824.0 44235.0 40997.0 33805.0 48309.0 38744.0 30690.0 33101.0 True False 44259.48649145602 32966.30214761299 40068.7504632458 38210.116690368726 35846.590342169824 38461.33189876357 50555.46422246747 38856.73862558552 36828.857550246736 32145.288123273487 1.3768576695198989 1.0255407268770156 1.2464890751511308 1.1886692862679382 1.1151429162713449 1.1964842794772528 1.5727177192686241 1.2087848917880093 1.1457000294728203 1.0 14.972319661445587 -7.027311019216669 24.994270294167464 1.2685424510219563 1.1815211863222894 0.0 0.15951899895511534 2299.92738773652 2104821.925678391 0.05932048757154675 0.04607507230544126 9.390505703156766e-08 7.027311019216669 -0.08702126469966687 VAASGAQDPEKS(ph)PDRLK ddPTM_A459_Selumetinib_30min_R1 2 VAASGAQDPEKSPDRLK 17 2 Q1MSJ5;Q1MSJ5-1;Q1MSJ5-2 Q1MSJ5 CSPP1 Centrosome and spindle pole-associated protein 1 1 VAAS(0.006)GAQDPEKS(0.994)PDRLK;VAAS(0.001)GAQDPEKS(0.999)PDRLK 73.294 0.028765 26073000.0 6592.9 7782.9 10240.5 10667.7 6298.0 8031.1 7679.200000000001 7314.7 4815.7 7079.2 True False 6746.501742449765 6871.6744498279495 8849.896347040029 8804.786452529803 5728.34701200221 7950.314425655364 7099.951761440616 7120.69039450583 8171.891175188119 7987.88427724739 0.8445918228518199 0.8602621434315415 1.1079149421640953 1.1022676527261754 0.7171294441907198 0.9952966454835808 0.8888400876893081 0.8914363487698906 1.0230357490862572 1.0 12.963597716861768 -8.27379688619233 24.018375510436552 1.0115179029538706 0.9298309390840406 0.08393529496666607 0.11247277991960741 1505.329914413408 2925750.80200307 0.10830002124202547 0.028872448209745626 5.323571774928626e-09 8.27379688619233 -0.08168696386982999 VAASMPLS(ph)PGGQMEEVAGAVK ddPTM_A459_Selumetinib_30min_R1 1 VAASMPLSPGGQMEEVAGAVK 21 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 VAASMPLS(1)PGGQMEEVAGAVK 267.92 8.224799999999997e-60 9036200.0 3039.3 3775.6 3842.0 3672.9 3542.8 3090.1 3272.7 2820.7 1538.3 2577.4 True False 3110.10977655168 3333.5509967711787 3320.2775025953615 3031.496963871943 3222.3543655321414 3059.016399586314 3025.837604134115 2745.88587307512 2610.3827470132865 2908.2343960020085 1.0694150997000766 1.146245640087972 1.1416815326714362 1.0423839866688138 1.1080105406778622 1.0518465787323015 1.0404380088117302 0.9441762592622962 0.8975833414946942 1.0 11.505927836011017 -7.469437763948901 1.4732498568826364 0.9367990858132283 1.102347416728055 0.7306437248304412 0.039578055591434486 0.20713254462485525 0.8648289699732976 0.02662197514991135 0.013194250441021967 3.392831066174984e-08 7.469437763948901 0.16554833091482657 VAASMPLS(ph)PGGQMEEVAGAVK ddPTM_A459_Selumetinib_30min_R2 2 VAASMPLSPGGQMEEVAGAVK 21 0 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 VAAS(0.067)MPLS(0.933)PGGQMEEVAGAVK;VAAS(0.001)MPLS(0.999)PGGQMEEVAGAVK 231.52 4.9732e-25 10897700.0 61857.0 58446.0 64507.0 74022.0 73455.0 57849.0 56045.0 52564.0 49781.0 60220.0 True False 58419.235573190395 62928.62026648992 60356.68984991121 63940.07590492772 64226.926203968214 65817.17464906297 58651.20355106069 52716.952537561374 59738.59099735529 58481.29212964958 0.9989388648198537 1.0760470224731162 1.032068335906532 1.093342393379003 1.098247385874801 1.1254398159183996 1.0029053978669695 0.901432759397501 1.0214991636114734 1.0 15.835687567181173 -7.511330356873665 24.312371578242733 0.9673133884755596 1.0708459177136096 0.5037020329974282 0.04391306443563046 294.9049184295691 620856.9757322912 0.019189383800601794 0.012100369020706152 3.080843538613361e-08 7.511330356873665 0.10353252923805001 VACIGAWHPAR ddPTM_A459_Selumetinib_30min_R2 2 VACIGAWHPAR 11 0 H7C422;Q92901;P39023;B5MCW2;G5E9G0 H7C422;P39023 RPL3;RPL3L 60S ribosomal protein L3-like;60S ribosomal protein L3 0 ; 148.94 0.00089911 7328000.0 66304.0 58357.0 60846.0 76867.0 72172.0 58746.0 65192.0 62480.0 59301.0 57919.0 False True 62619.08911594192 62832.79425266999 56931.23460411579 66397.581997029 63105.10813413371 66837.72825690766 68223.55717549729 62661.80645587917 71162.85700838003 56246.72797836553 1.1132930103956877 1.1170924338361103 1.0121697145834605 1.1804701248145109 1.121933851128303 1.188295402403066 1.2129337941531189 1.114052473949793 1.2651910531711599 1.0 15.779481552915819 -5.791178836128 24.993713986702627 1.1619102527975722 1.0844756844608772 0.17652562980876652 0.07178916601012252 304.053065237327 255531.85107237683 0.018949539571833474 0.028111194379345117 1.6174138730714506e-06 5.791178836128 -0.07743456833669504 VADAKGDS(ph)ES(ph)EEDEDLEVPVPSR ddPTM_A459_Selumetinib_30min_R2 1 VADAKGDSESEEDEDLEVPVPSR 23 1 P13861;P13861-2 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 2 VADAKGDS(1)ES(1)EEDEDLEVPVPSR 65.223 0.0087615 4523700.0 26734.0 23279.0 20667.0 22037.0 19263.0 17335.0 16409.0 16329.0 15511.0 21906.0 True False 25248.23130468133 25064.424446217334 19337.307720528217 19035.52258405462 16843.00972659504 19722.738898537682 17172.05101381665 16376.514686588527 18613.6334135509 21273.51686137668 1.1868386157871704 1.1781984431414474 0.9089849998255923 0.8947990455971447 0.7917360273032482 0.9271028869864707 0.8072032060196647 0.7698075872128624 0.8749673847931108 1.0 14.376770933725174 -5.305971510333459 2.9037076446430854 0.8551535244946229 1.196765607904265 0.7861688003970191 0.0648849178640391 0.10562739831574502 1.7470325594252636 0.017090908618987957 0.047769932677302285 4.943431147729352e-06 5.305971510333459 0.3416120834096421 VADAKGDS(ph)ESEEDEDLEVPVPSR ddPTM_A459_Selumetinib_30min_R1 1 VADAKGDSESEEDEDLEVPVPSR 23 1 P13861;P13861-2 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 VADAKGDS(0.773)ES(0.227)EEDEDLEVPVPSR 80.355 0.00031406 5478900.0 509.42 393.67 632.23 523.49 472.29 513.29 251.52 304.08 296.01 363.99 True False 521.288494841232 347.5789333877821 546.376638590803 432.07229862433576 429.571452889572 508.12676863003134 232.54764390008629 296.01481060895605 502.3073502849917 410.71166206284295 1.269232269234833 0.8462845482449415 1.3303168355302315 1.0520088386441397 1.0459197840450982 1.2371861224439322 0.5662065760005232 0.720736316865682 1.2230170133521403 1.0 8.68198210266598 -7.235017067877054 24.997910074491518 0.8542178983514117 1.1189716002803394 0.2619710872578247 0.20577456450664344 980.4082111235974 927556.601779738 0.07693539041071763 0.05957638338555314 5.8208034142465666e-08 7.235017067877054 0.26475370192892766 VADAKGDS(ph)ESEEDEDLEVPVPSR ddPTM_A459_Selumetinib_30min_R2 1 VADAKGDSESEEDEDLEVPVPSR 23 1 P13861;P13861-2 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 VADAKGDS(0.996)ES(0.004)EEDEDLEVPVPSR 99.569 2.8967e-05 5511100.0 20556.0 21105.0 19690.0 20679.0 18637.0 14764.0 15285.0 15457.0 10862.0 19878.0 True False 19413.579812187832 22723.685636729108 18423.166836851058 17862.48452673529 16295.653443106046 16797.606985751983 15995.782786652902 15501.977310955892 13034.703509637675 19304.070490753467 1.0056728616633897 1.1771447709753036 0.9543669479281918 0.9253221767549653 0.8441563374373071 0.8701588089308903 0.8286222739558885 0.8030418930754135 0.6752308284349261 1.0 14.236617468371303 -5.758399614555874 1.2994213863056499 0.8233553592387279 1.0968415204809807 0.549823814854979 0.08745513750633441 0.32679031024347993 1.0942446703418176 0.02914172979570443 0.07345954607115167 1.7442164795838364e-06 5.758399614555874 0.2734861612422528 VADAKGDSES(ph)EEDEDLEVPVPSR ddPTM_A459_Selumetinib_30min_R1 1 VADAKGDSESEEDEDLEVPVPSR 23 1 P13861;P13861-2 P13861 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 VADAKGDS(0.372)ES(0.628)EEDEDLEVPVPSR 61.022 0.0054507 6920900.0 950.71 1027.8 1331.5 1270.9 943.85 938.77 999.95 1215.1 655.09 902.42 True False 972.8596932403672 907.4646981887428 1150.6896134059666 1048.961172747652 858.4789341502521 929.3268261349612 924.522966435636 1182.871600798943 1111.6398841194398 1018.2543973151759 0.9554190935050213 0.8911964442102568 1.1300610303672458 1.0301562905237045 0.8430888552151579 0.912666646552483 0.9079489063571139 1.161666086508256 1.0917113513582586 1.0 9.99188232927211 -7.75645042030453 24.999840496037034 1.0950165449102545 0.9545684981626731 0.33829571377346557 0.08388445027458963 139.64055373562582 699754.565186772 0.04355348795997594 0.024132496710707364 1.7520624408115768e-08 7.75645042030453 -0.14044804674758138 VADNS(ph)FDAK ddPTM_A459_Selumetinib_30min_R1 2 VADNSFDAK 9 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 VADNS(1)FDAK;VADNS(1)FDAK 155.88 0.00083125 239200000.0 12222.8 15193.1 15171.1 15623.900000000001 12166.9 12373.099999999999 13429.199999999999 12348.3 7948.7 10981.0 True False 12507.567458571337 13414.284788919435 13110.947948887171 12895.479161926221 11066.406043240657 12248.637847875942 12416.22463208905 12020.782971068715 13488.363349921672 12390.518313997854 1.0094466705594753 1.082624991866967 1.0581436237478 1.0407538115139139 0.8931350378408853 0.9885492711017886 1.002074676574438 0.9701598162756887 1.0886036409537088 1.0 13.59694891839148 -6.026297023001274 24.74926933114087 0.987374540308122 1.0526807183849223 0.2584299123828595 0.04753664201250312 815.9950648896125 767967.6565821227 0.013966880093423761 0.018101666254830763 9.412456389307644e-07 6.026297023001274 0.06530617807680028 VADNS(ph)FDAK ddPTM_A459_Selumetinib_30min_R2 2 VADNSFDAK 9 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 VADNS(1)FDAK;VADNS(1)FDAK 110.64 0.010737 79096000.0 201967.0 188987.0 195664.0 206709.0 183258.0 155379.0 192209.0 211734.0 162162.0 189234.0 True False 190742.4826779598 203481.69521101774 183075.19126285572 178554.8776070858 160235.49169269335 176781.04685987244 201147.09935490822 212350.11088554922 194598.93118485223 183770.32273102156 1.0379395314941204 1.1072609123555115 0.9962173899580985 0.9716197640270272 0.8719334510133318 0.9619673309200252 1.0945570338325001 1.1555190616732982 1.0589246854057068 1.0 17.487544277485213 -7.270193138143893 24.364546524254255 1.0902101276371874 0.9903566663590762 0.2775436892522911 0.0667435122272336 605.5695439498991 1685487.8949054398 0.03052689621062116 0.02095193671497698 5.3679302229233285e-08 7.270193138143893 -0.09985346127811123 VADNS(ph)FDAKR ddPTM_A459_Selumetinib_30min_R1 1 VADNSFDAKR 10 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 VADNS(1)FDAKR 78.40100000000002 0.027014 77731000.0 4367.5 4374.7 5884.4 6568.5 5628.2 4732.2 5056.2 4776.6 2934.5 4324.4 True False 4469.254252324369 3862.5080902571435 5085.330800695512 5421.434781015779 5119.1303037394155 4684.598364493823 4674.806763230024 4649.909051416537 4979.632172599941 4879.47886322305 0.9159286017220875 0.7915820927864077 1.0421872792654112 1.1110684015617909 1.0491141466607496 0.9600612064952153 0.9580545165313343 0.9529519815042554 1.0205254110498876 1.0 12.252511358353674 -5.268412773836981 24.991320626214236 1.0111835414896106 0.8537553447457553 0.5780764621628132 0.05398835634991811 367.198003035619 1315971.52851137 0.015590629660092262 0.033604316291394015 5.389980899312573e-06 5.268412773836981 -0.15742819674385533 VADPDHDHTGFLTEY(ph)VATR ddPTM_A459_Selumetinib_30min_R1 3 VADPDHDHTGFLTEYVATR 19 0 P28482-2;P28482 P28482-2 MAPK1 Mitogen-activated protein kinase 1 1 VADPDHDHTGFLT(0.016)EY(0.983)VAT(0.001)R;VADPDHDHTGFLT(0.001)EY(0.996)VAT(0.003)R;VADPDHDHTGFLT(0.001)EY(0.999)VATR 191.44 1.9303e-14 26268400.0 2281.1 3404.9 3024.98 3422.7 3764.42 8981.099999999999 19685.2 24307.9 16754.1 4092.1000000000004 True False 2334.245191752059 3006.252725104936 2614.2043310257473 2824.989697036263 3423.928875662333 8890.758288186353 18200.329515354566 23663.175528812975 28430.484028950967 4617.360895429431 0.5055366571113488 0.6510759702757312 0.5661685084251178 0.6118191237407118 0.741533736089714 1.9255064721033637 3.941716908758519 5.124826944377761 6.15730168657454 1.0 12.172852783282456 -7.140171857846868 2.1976718173915355 4.50204708484097 0.6073661582016159 0.6248986872315608 1.2445505508424748 0.18441710004835932 1.7465398101131915 0.5454314797772961 0.38803801406063715 7.241493449340567e-08 7.140171857846868 -3.894680926639354 VADPDHDHTGFLTEY(ph)VATR ddPTM_A459_Selumetinib_30min_R2 4 VADPDHDHTGFLTEYVATR 19 0 P28482-2;P28482 P28482-2 MAPK1 Mitogen-activated protein kinase 1 1 VADPDHDHTGFLTEY(1)VATR;VADPDHDHTGFLT(0.001)EY(0.998)VAT(0.001)R;VADPDHDHTGFLTEY(1)VATR;VADPDHDHTGFLTEY(0.999)VAT(0.001)R 155.63 2.7135000000000004e-06 12308500.0 10613.400000000001 11208.4 10512.7 15987.5 19938.899999999998 22136.6 46732.6 88120.0 145852.0 251523.0 True False 10023.549716806498 12068.048239313654 9836.324327362325 13809.974920024204 17433.99712597238 25185.715713952657 48905.75849889015 88376.41461094873 175026.4754453761 244260.8774547636 0.04103624707015486 0.049406390270372386 0.04026974941651875 0.056537809345181655 0.07137449643036309 0.10310990436287522 0.2002193679499385 0.36181158248445167 0.7165555011067644 1.0 17.89806328433005 -8.23365845670277 1.0668875803633435 1.0061551805665319 0.05108321894890094 0.9978365985151054 0.01479639695211458 0.019782900933730908 0.04531608975227396 0.014327513197436992 0.004863185621169594 5.839041249392482e-09 8.23365845670277 -0.955071961617631 down VADPDHDHTGFLTEYVAT(ph)R ddPTM_A459_Selumetinib_30min_R2 1 VADPDHDHTGFLTEYVATR 19 0 P28482-2;P28482 P28482-2 MAPK1 Mitogen-activated protein kinase 1 1 VADPDHDHTGFLT(0.08)EY(0.383)VAT(0.536)R 119.96 0.00059619 4365300.0 6105.8 1799.1 8689.8 13040.0 10084.0 13078.0 20772.0 37485.0 48080.0 88943.0 True False 5766.464079454 1937.0851849817268 8130.707728738863 11263.929504745309 8817.157767896193 14879.375789736136 21737.939158937133 37594.07514402419 57697.34346744423 86374.98448833315 0.06676081175138027 0.022426460582963957 0.09413266788878086 0.1304073114625769 0.10207999249003795 0.17226487365385199 0.25166938422864 0.43524262686382414 0.6679867302926987 1.0 16.398325925963725 -8.23611734974668 0.7799203937183788 1.005870536276573 0.07021277266409388 0.9937754374698311 0.023718613224165172 0.04455926641855086 0.05879232922627256 0.024425669182798176 0.009653459740834303 5.806075116584241e-09 8.23611734974668 -0.9356577636124791 down VADPDHDHTGFLTEYVATR ddPTM_A459_Selumetinib_30min_R1 2 VADPDHDHTGFLTEYVATR 19 0 P28482-2;P28482 P28482-2 MAPK1 Mitogen-activated protein kinase 1 0 ; 89.374 0.0016514 10180900.0 4658.6 5370.200000000001 6163.700000000001 5833.4 5894.9 5125.4 5412.6 5066.6 3207.8999999999996 4366.200000000001 False True 4767.136315942373 4741.454487461755 5326.703394780591 4814.70619647978 5361.707335829126 5073.843129490858 5004.323224290738 4932.217309363781 5443.572004253992 4926.64430038953 0.9676234015038297 0.9624105574430991 1.0812031618275 0.9772790367875961 1.0883081888832928 1.02987811177878 1.0157671062014901 1.0011311977553992 1.1049249087910793 1.0 12.266389598693205 -5.236545441654136 24.19719231517383 1.0359942416955867 0.9650169381532417 0.34357174399083146 0.03993827404157467 554.9053389180352 539371.1028017016 0.009521698852504859 0.025163844666503832 5.800354783354888e-06 5.236545441654136 -0.070977303542345 VAEFHTELER ddPTM_A459_Selumetinib_30min_R2 1 VAEFHTELER 10 0 K7EJC1;K7EJR3;R4GMR5;P48556;K7ERW6 K7EJC1 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 147.3 0.0011659 5339800.0 39330.0 44989.0 43815.0 47437.0 48277.0 37327.0 34563.0 35704.0 32335.0 39762.0 False True 37144.19605046444 48439.511637564814 40995.990602165 40975.99876661064 42212.01165814403 42468.45542923081 36170.24798528523 35807.8927288846 38802.90351538705 38613.96774591707 0.9619367865761984 1.2544556922070427 1.0616881143093564 1.0611703784556903 1.0931798549142209 1.0998210727443647 0.936714098465309 0.927330052288419 1.0048929385012488 1.0 15.23683518436672 -7.25647414939357 24.673853783509472 0.9611784411967679 1.0939659024140933 0.4100444549087088 0.07106564121233881 315.12893910555437 1565982.211327428 0.02664616348111035 0.01997369373936042 5.54020520043021e-08 7.25647414939357 0.13278746121732543 VAEIEHAEK ddPTM_A459_Selumetinib_30min_R1 2 VAEIEHAEK 9 0 F8VQ14;F5GWF6;P78371-2;P78371 F8VQ14 CCT2 T-complex protein 1 subunit beta 0 ; 137.98 0.0035218000000000007 19439200.0 20567.0 20163.7 18674.1 18010.9 19670.5 17488.9 19600.3 19682.9 11837.1 16739.5 False True 21046.171083584515 17802.92463015018 16138.259789488813 14865.634421465653 17891.306748108833 17312.977544650697 18121.83359070793 19160.845552930234 20086.69415242213 18888.17788153784 1.1142509995183811 0.9425432533411053 0.8544106207969949 0.7870338004385271 0.9472224827783207 0.9166039018286241 0.9594273044421628 1.0144358906985365 1.0634532498794271 1.0 14.205195913035297 -7.654341751610339 2.251457120031946 1.0342312653607526 0.9189184148976831 0.2336223245729021 0.0795038652069737 0.45782166614632824 4.637710850357188 0.05297207083051815 0.02489567003103409 2.2164515806641137e-08 7.654341751610339 -0.1153128504630695 VAEIEHAEK ddPTM_A459_Selumetinib_30min_R2 2 VAEIEHAEK 9 0 F8VQ14;F5GWF6;P78371-2;P78371 F8VQ14 CCT2 T-complex protein 1 subunit beta 0 ; 118.03 0.010317 12354300.0 223820.0 192588.0 207978.0 237680.0 223630.0 171032.0 194339.0 209896.0 173578.0 193508.0 False True 211380.98042244985 207358.8803319774 194596.92190932512 205307.57397913112 195535.60012243435 194590.10552608588 203376.14857542288 210506.7626098466 208298.45017454293 187920.92124583616 1.1248400604950393 1.1034369082339304 1.0355255850132592 1.0925211127001124 1.0405206553166944 1.0354893123981932 1.0822432501241752 1.120188008946933 1.108436723243013 1.0 17.51976616544927 VAELALSLSST(ph)SDDEPPSSVSHGAK ddPTM_A459_Selumetinib_30min_R1 1 VAELALSLSSTSDDEPPSSVSHGAK 25 0 Q5T7F5;Q8N1G2 Q5T7F5 CMTR1 Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 1 VAELALSLS(0.004)S(0.1)T(0.511)S(0.385)DDEPPSSVSHGAK 149.09 9.4024e-10 20983000.0 2014.3 2234.6 2359.9 2252.9 3589.6 2713.2 3570.8 2116.3 594.62 1065.0 True False 2061.2292708544883 1972.971993162643 2039.4385420028104 1859.4733071706544 3264.9213137953548 2685.9076713884942 3301.451681132427 2060.1688492887874 1009.0267106734973 1201.7031239784824 1.7152566467750954 1.6418131515134273 1.69712344197861 1.5473649606688964 2.716911730233478 2.2350842049043287 2.747310558869399 1.7143742145465843 0.839663882484477 1.0 10.23086481260407 VAELALSLSST(ph)SDDEPPSSVSHGAK ddPTM_A459_Selumetinib_30min_R2 1 VAELALSLSSTSDDEPPSSVSHGAK 25 0 Q5T7F5;Q8N1G2 Q5T7F5 CMTR1 Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 1 1 VAELALS(0.004)LS(0.028)S(0.12)T(0.707)S(0.139)DDEPPS(0.001)S(0.001)VSHGAK 91.583 0.0012297 0.0 4839.3 3959.6 6648.9 7655.8 7554.5 4175.6 4819.7 4322.1 5359.5 5593.7 True False 4570.351079252799 4263.288587879296 6221.11701277496 6613.066833008367 6605.436171913109 4750.750997677186 5043.8256000543715 4334.67659543783 6431.54975694192 5432.195346822 0.8413451261333217 0.7848187179743913 1.1452307245199684 1.2173838403799697 1.2159791300173863 0.8745545206610658 0.9285059314012268 0.7979603675287097 1.183968790942795 1.0 12.407319645839712 -5.248877059605439 24.334601806250493 1.0401833470397226 0.8130818732974654 0.305593740138699 0.1399294261263035 741.279494490958 1435930.4349925984 0.039228088118916336 0.10216112887974697 5.6379723336489284e-06 5.248877059605439 -0.2271014737422572 VAEPGAEATSSTGEES(ph)GSEHPPAVPMHNK ddPTM_A459_Selumetinib_30min_R1 1 VAEPGAEATSSTGEESGSEHPPAVPMHNK 29 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VAEPGAEAT(0.058)S(0.169)S(0.045)T(0.045)GEES(0.341)GS(0.341)EHPPAVPMHNK 58.924 0.0023302 28596000.0 4506.8 5289.2 3513.0 3736.4 7361.5 3964.8 6524.7 5016.0 1063.3 2851.9 True False 4611.799671293755 4669.938005117629 3035.953895527723 3083.9078809145685 6695.653624778389 3924.917711750369 6032.5366259338925 4882.959385735744 1804.3424396406588 3217.9691448584335 1.4331398045448442 1.451206582443186 0.9434378512853274 0.9583397919902172 2.0807078388170646 1.2196878015507 1.8746409161730104 1.5174040414705585 0.5607084339275218 1.0 11.65193477766778 -8.25415929086178 24.953869814088932 0.7803542013350196 1.432123836804333 0.35797328453753363 0.35057431444335624 553.645958242567 1897742.3825949677 0.2538582225244733 0.09158137200753057 5.569814213913624e-09 8.25415929086178 0.6517696354693133 VAEPGAEATSSTGEES(ph)GSEHPPAVPMHNK ddPTM_A459_Selumetinib_30min_R2 2 VAEPGAEATSSTGEESGSEHPPAVPMHNK 29 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VAEPGAEAT(0.007)S(0.068)S(0.018)T(0.018)GEES(0.662)GS(0.227)EHPPAVPMHNK;VAEPGAEAT(0.032)S(0.032)S(0.037)T(0.037)GEES(0.589)GS(0.272)EHPPAVPMHNK 71.42699999999998 0.00013019 67635000.0 130201.0 85140.0 142167.0 207299.0 232285.0 155178.0 162061.0 181713.0 200948.0 171894.0 True False 122964.94965589949 91669.96423175166 133020.12999972602 179064.51858927883 203103.2816457522 176552.3609343686 169597.15761777922 182241.75474579335 241143.2149562391 166930.97358575193 0.7366215329279966 0.5491489222319852 0.7968570909424068 1.0726860015423916 1.2166902120259826 1.0576369210694994 1.0159717754875353 1.0917192347900393 1.4445684331455995 1.0 17.348892142095238 -5.682482460513366 2.8486030384569334 1.1335275490683208 0.644845311772887 0.7178827324640235 0.12744628338371955 0.1339953803789268 2.188553087163666 0.03654879322739898 0.06893705731421637 2.077387621588259e-06 5.682482460513366 -0.4886822372954338 VAEPGAEATSSTGEES(ph)GSEHPPAVPMHNKR ddPTM_A459_Selumetinib_30min_R2 1 VAEPGAEATSSTGEESGSEHPPAVPMHNKR 30 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VAEPGAEAT(0.005)S(0.029)S(0.029)T(0.059)GEES(0.439)GS(0.439)EHPPAVPMHNKR 45.328 0.026603 5641100.0 7795.9 7624.4 12035.0 14964.0 13939.0 8777.4 6257.5 7016.5 6972.1 14534.0 True False 7362.63508746035 8209.16696369 11260.681202717244 12925.877385660182 12187.858203758924 9986.407176695971 6548.486149001016 7036.916853355899 8366.714816750584 14114.365656132948 0.5216412318368095 0.5816178469290945 0.7978170239499409 0.9157958423759309 0.8635073300983299 0.7075349626043376 0.4639589414459856 0.4985641597217818 0.5927800809889812 1.0 13.784876670553414 -7.01975057092352 23.8834104345037 0.5954262266007948 0.7453705420648894 0.04060085210070219 0.17691080064060696 931.383637066112 1126274.4913430016 0.06874051269708965 0.05409033588466963 9.555412260469091e-08 7.01975057092352 0.1499443154640946 VAESAQS(ph)PAAAHTTDTAGYNAMEESVSR ddPTM_A459_Selumetinib_30min_R1 2 VAESAQSPAAAHTTDTAGYNAMEESVSR 28 0 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;K7EPC7 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 VAES(0.017)AQS(0.965)PAAAHT(0.017)TDTAGYNAMEESVSR;VAES(0.012)AQS(0.987)PAAAHT(0.001)TDTAGYNAMEESVSR 155.3 2.6571e-17 11519800.0 1411.8600000000001 1357.4099999999999 1438.6399999999999 1601.85 2063.16 1570.3600000000001 1966.28 1436.22 403.72 945.74 True False 1444.7535909986682 1198.4838061572111 1243.2805898838596 1322.1169679485613 1876.547542280482 1554.5636041727996 1817.9619165388906 1398.126780099957 685.0833534578454 1067.1349412877087 1.3538621359874958 1.1230855253516525 1.165064081196326 1.2389407532220496 1.7584913300805778 1.4567638487189936 1.7035914074232834 1.3101686825218575 0.6419838081875169 1.0 10.05952690395216 -8.167873169303137 5.78933801771155 0.8266930253124011 1.396752467894225 0.5354048920984196 0.21236861240839675 0.17828407166147414 8.650560881441432 0.16259858621157738 0.059268675456530584 6.794020151744434e-09 8.167873169303137 0.5700594425818238 VAESAQS(ph)PAAAHTTDTAGYNAMEESVSR ddPTM_A459_Selumetinib_30min_R2 2 VAESAQSPAAAHTTDTAGYNAMEESVSR 28 0 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;K7EPC7 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 VAES(0.27)AQS(0.728)PAAAHT(0.002)TDTAGYNAMEESVSR;VAES(0.069)AQS(0.931)PAAAHTTDTAGYNAMEESVSR 155.3 2.6571e-17 17024600.0 16997.5 17891.4 21289.5 35658.0 33530.0 26108.0 19127.2 22887.0 26522.0 26862.0 True False 16052.846996383665 19263.61285008175 19919.75674825498 30801.318886519006 29317.661637996775 29704.140015172892 20016.65269982777 22953.597380853193 31827.14108659641 26086.424264142242 0.6153716904178973 0.73845355940795 0.7636062553669414 1.1807413148937296 1.1238666266076225 1.1386819333458236 0.7673206759633273 0.8799058525013964 1.220065301565505 1.0 14.671011583193833 -5.6272093186714125 5.788095022402913 1.0342704903835087 0.6946988348723075 0.5750684498126963 0.1341873570102363 0.16281410950920722 7.749700576623989 0.03952130552182139 0.06935227224262247 2.3593408180450504e-06 5.6272093186714125 -0.33957165551120116 VAFISLS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 VAFISLSPVR 10 0 Q6ZU65-2;Q6ZU65 Q6ZU65-2 UBN2 Ubinuclein-2 1 VAFISLS(1)PVR;VAFISLS(1)PVR 163.46 0.00039167 26598000.0 5376.200000000001 5490.6 5366.0 5452.1 5525.0 4263.9 4810.4 4801.0 2636.2 4253.8 True False 5501.454999735837 4847.757999489309 4637.326673328141 4499.993083592315 5025.264725517978 4221.0090373114435 4447.54765512474 4673.661884154166 4473.438859569927 4799.816665520816 1.1461802362692717 1.0099881594046867 0.966146625274271 0.9375343679098693 1.0469701398423514 0.8794104715775498 0.9266078196430755 0.9737167500015417 0.9320020265991817 1.0 12.22876358616354 -4.4994070640569435 1.444101035364475 0.9537768388047141 1.356835769001099 0.6386154749182311 0.042793133369739805 1.4883675606642153 1.694190646341452 0.012040846614495714 1.05278423703482 3.166598020481087e-05 4.4994070640569435 0.40305893019638495 VAFISLS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 2 VAFISLSPVR 10 0 Q6ZU65-2;Q6ZU65 Q6ZU65-2 UBN2 Ubinuclein-2 1 VAFIS(0.049)LS(0.951)PVR;VAFIS(0.008)LS(0.992)PVR 108.98 0.010346 13486400.0 21722.8 17854.7 25917.0 25313.2 29167.0 20392.4 19737.5 21650.0 16373.400000000001 19233.1 True False 20515.533739258295 19224.09807809084 24249.52843629604 21865.49849229438 25502.78070371164 23201.267996223836 20655.33285911427 21712.99791564956 19648.53751102021 18677.790429404908 1.0983919011619374 1.0292490512060712 1.2983081980681939 1.1706683708085184 1.3654067273162023 1.2421848335816803 1.105876679427566 1.162503562598403 1.0519733362082826 1.0 14.189036174795836 -8.241792095133254 1.3033976665714406 1.0006083639207946 1.1972345451936306 0.33196628509894066 0.09272929652716538 0.5352967651036321 1.7671048739609203 0.09336112611047004 0.02967368604865091 5.73070304771499e-09 8.241792095133254 0.19662618127283604 VAFISLS(ph)PVRR ddPTM_A459_Selumetinib_30min_R2 1 VAFISLSPVRR 11 1 Q6ZU65-2;Q6ZU65 Q6ZU65-2 UBN2 Ubinuclein-2 1 VAFIS(0.018)LS(0.982)PVRR 81.23899999999998 0.021697 3998400.0 19885.0 19746.0 27974.0 26044.0 23774.0 19632.0 16543.0 18852.0 15016.0 21314.0 True False 18779.871305962006 21260.454706602843 26174.183295788294 22496.762271594063 20787.29757774338 22336.129798447768 17312.282279332627 18906.856198883383 18019.619582095307 20698.6094395774 0.9073011093225125 1.027144106886289 1.2645382469868316 1.086873122432005 1.0042847389543184 1.079112578245923 0.8363983256880124 0.9134360573388064 0.8705715055254074 1.0 14.337246228336257 -7.250600083057253 24.373791521645998 0.8978878103999065 1.0677546434656315 0.40446474452351144 0.0926483021633471 511.2809995293127 1149694.0100308545 0.03734130467828582 0.028617563462229177 5.6156485096024746e-08 7.250600083057253 0.16986683306572503 VAFSEITS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 2 VAFSEITSPSK 11 0 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 VAFSEIT(0.123)S(0.877)PSK;VAFSEIT(0.035)S(0.748)PS(0.216)K 150.09 0.00064275 2230000.0 93002.0 81170.0 86762.0 87263.0 79038.0 81373.0 91339.0 98059.0 86388.0 87147.0 True False 87833.3211565038 87395.4779973134 81179.82737932296 75377.62886292874 69108.53983131482 92581.39211945246 95586.44448479479 98344.33545545876 103668.01388239561 84630.83967490162 1.0378405968073114 1.0326670316994582 0.959222757226145 0.8906638425482024 0.8165881385176644 1.0939439154224613 1.1294516851301215 1.1620389899620014 1.2249436999635455 1.0 16.368895860134856 -6.941507275166296 8.685349204707755 1.1382811457400135 0.9497014595438918 0.5487522732418555 0.07951930930053645 0.22807479380339196 31.017741516964346 0.029753866750388033 0.02622076781853855 1.1441757127802166e-07 6.941507275166296 -0.18857968619612164 VAFSEITS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 1 VAFSEITSPSKR 12 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 VAFS(0.027)EIT(0.126)S(0.846)PS(0.001)KR 116.24 0.0090873 27051000.0 4177.5 4660.9 5869.3 5991.3 4466.6 4312.7 4182.0 3625.2 2752.7 3455.9 True False 4274.82762200001 4115.199661206378 5072.281297757145 4945.031925629875 4062.5968186422815 4269.318153618296 3866.548373052483 3529.047919690831 4671.130850746583 3899.4984283166536 1.0962506334039939 1.0553151224073807 1.3007522354475627 1.2681199945410826 1.0418254791799044 1.0948377674975207 0.991550181165634 0.9050004723849217 1.1978799162545193 1.0 11.929072854402207 -6.3513459957391944 8.132245637273249 1.0336344659447878 1.1796255662021125 0.3353715744067114 0.09753005866834989 0.38518315072284276 31.53713917471334 0.03167631987456049 0.03592330047724781 4.4530134230644423e-07 6.3513459957391944 0.14599110025732465 VAFT(ph)GSTEVGK ddPTM_A459_Selumetinib_30min_R1 1 VAFTGSTEVGK 11 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 VAFT(0.788)GS(0.106)T(0.106)EVGK 122.33 0.0097851 12172000.0 2388.3 6491.8 3305.8 3660.2 3777.3 4148.8 4885.8 4702.5 1047.5 3742.0 True False 2443.9427431771715 5731.737038044056 2856.890517459591 3021.0147804634144 3435.643881936478 4107.066838809003 4517.260172419853 4577.774424127258 1777.5309936270014 4222.322150166648 0.5788148455419758 1.357484539122112 0.6766159510938394 0.7154865671119339 0.8136858723110171 0.9727033354494052 1.0698520889131031 1.08418407248878 0.42098421920668594 1.0 12.043820940731653 -10.792193403041747 3.709078914628858 1.0002037271565545 0.8752778507779425 0.021602154619998926 0.26202716550607447 365806356.4109353 378470130.8476217 912189.6237169183 0.06313520691251044 1.6136397994895155e-11 10.792193403041747 -0.12492587637861197 VAFTGSTEVGK ddPTM_A459_Selumetinib_30min_R1 1 VAFTGSTEVGK 11 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 185.6 0.00026331 18373000.0 2451.9 2617.9 2029.0 2374.8 2217.6 2161.6 2537.3 2243.7 1397.3 1991.9 False True 2509.024499433114 2311.3950509713095 1753.472944499217 1960.0857605170538 2017.0184715490782 2139.8562665757663 2345.9094182080494 2184.1897874352653 2371.1160452458334 2247.5797677490496 1.116322782147973 1.0283928891592449 0.7801604951513332 0.872087295250962 0.8974179695384612 0.9520713334765563 1.0437491260020892 0.97179633789938 1.0549641348749572 1.0 11.134156603291162 -7.10893382457778 5.130643621844438 1.0147356057027495 0.9307339002930949 0.15398954609551907 0.08704905600187594 0.46609497637760644 18.196214006698508 0.03682522274228748 0.028465233628066564 7.781551130346227e-08 7.10893382457778 -0.08400170540965457 VAFTGSTEVGK ddPTM_A459_Selumetinib_30min_R2 2 VAFTGSTEVGK 11 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ; 196.52 0.00027083 57395000.0 111090.0 103904.0 107137.0 116609.0 117200.0 75299.0 84577.0 97918.0 78843.0 97692.0 False True 104916.0625285049 111873.10269598194 100243.92206194576 100726.65303825478 102476.28821870622 85670.75375373467 88509.99808614604 98202.9251688024 94613.80305748153 94871.37812570136 1.1058768682530855 1.17920815430502 1.0566297659250397 1.0617180337023815 1.0801602152645935 0.9030200198022191 0.932947321255029 1.035116460927624 0.9972850076249704 1.0 16.533685283821114 -6.047277861608437 1.143684606083888 0.9782666748433172 1.1349389897891715 0.5944886684114314 0.04912892564227079 0.3595874040528349 0.9605723163519133 0.020511875141598353 0.038552297070278616 8.968548031996642e-07 6.047277861608437 0.15667231494585432 VAGAAT(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 VAGAATPK 8 0 P16402 P16402 HIST1H1D Histone H1.3 1 VAGAAT(1)PK 110.54 0.005017 4580900.0 2802.3 4418.4 2532.4 2485.1 2121.4 2822.8 1975.4 1907.6 1984.1 2689.9 True False 2867.5881376734005 3901.091673941567 2188.513989477485 2051.1239361044836 1929.519744563589 2794.4051948973315 1826.3939875963365 1857.0042512419266 3366.8727870695297 3035.1748668448063 0.9447851486245274 1.2852938776463045 0.7210503794638161 0.6757844361819965 0.6357194656693396 0.9206735418846674 0.6017425906978964 0.6118277637071902 1.109284616134667 1.0 11.56756392215205 -5.275049467884094 24.80455394043188 0.7597855638015556 1.1150395153009467 0.3368280794759275 0.18290126629443496 608.0687884110863 1108213.2083126325 0.0458230129171886 0.0962513387856518 5.308239778063676e-06 5.275049467884094 0.3552539514993911 VAGGAAPSKPAS(ph)AK ddPTM_A459_Selumetinib_30min_R1 1 VAGGAAPSKPASAK 14 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 VAGGAAPSKPAS(1)AK 153.41 0.0017271 34460000.0 3705.2 3496.3 4554.3 4236.5 3063.8 2663.3 2751.2 3018.3 2213.0 2969.0 True False 3791.523950935832 3086.9515706142265 3935.851074979193 3496.6748039542254 2786.679830957823 2636.509620082919 2543.6747689961735 2938.244879179862 3755.299368874991 3350.1000705090282 1.1317643864768887 0.9214505553994339 1.1748458231521315 1.0437523448136659 0.8318198777072361 0.7869942881086285 0.7592832200411485 0.8770618242258694 1.1209514014022857 1.0 11.709988475477525 -6.19945961142375 6.247231934233272 0.877743325313461 1.066855320355194 0.3373020733559411 0.11654608242452229 0.26236654039378354 20.79644681367204 0.03551761668041801 0.045876705766875595 6.317429274689077e-07 6.19945961142375 0.18911199504173304 VAGGAAPSKPAS(ph)AK ddPTM_A459_Selumetinib_30min_R2 1 VAGGAAPSKPASAK 14 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 VAGGAAPS(0.001)KPAS(0.999)AK 142.4 0.002594 9237100.0 31626.0 33631.0 36840.0 43001.0 37916.0 29233.0 40569.0 39604.0 25601.0 35073.0 True False 29868.353528908923 36210.389559291 34469.75450835922 37144.18961913748 33152.65310665927 33259.580399247345 42455.53888594846 39719.241083204826 30721.91535170632 34060.35135940216 0.8769244102546212 1.0631243693643029 1.0120199332249122 1.090540412434238 0.9733502968549876 0.97648964475718 1.2464797687481537 1.1661430225452025 0.9019846867559022 1.0 15.055805697180482 VAGGAAPSKPAS(ph)AKK ddPTM_A459_Selumetinib_30min_R1 1 VAGGAAPSKPASAKK 15 2 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 1 VAGGAAPS(0.01)KPAS(0.99)AKK 88.637 0.019693 26926000.0 4195.3 5107.9 6318.1 6967.0 4761.7 4230.6 4927.1 4548.6 2917.4 4720.1 True False 4293.042327367241 4509.864693401715 5460.136722839082 5750.344236787229 4331.005075746414 4188.044005077461 4555.444880169034 4427.95635206491 4950.614721534527 5325.970812667447 0.806058177629615 0.8467685708444589 1.0251908834822248 1.0796800130992907 0.8131860327595907 0.7863437770099103 0.8553266700850536 0.8313895264940858 0.9295234419535005 1.0 12.378828806989189 VAGS(ph)PVTPLPEQEASPAR ddPTM_A459_Selumetinib_30min_R2 2 VAGSPVTPLPEQEASPAR 18 0 O15047 O15047 SETD1A Histone-lysine N-methyltransferase SETD1A 1 VAGS(0.995)PVT(0.005)PLPEQEASPAR;VAGS(0.999)PVT(0.001)PLPEQEASPAR 208.59 1.5332e-11 10689300.0 25336.0 18950.3 21509.7 27019.0 27071.0 22746.4 25380.0 27433.0 25456.0 18530.8 True False 23927.926548043913 20403.727075181596 20125.789319990603 23338.96558962525 23670.098962189393 25879.51012873943 26560.220289515906 27512.825488222385 30547.911300067797 17995.767655199437 1.3296418917217196 1.1338069854045063 1.1183623675078818 1.2969141431919982 1.3153147682116522 1.438088700887521 1.4759148261086812 1.52884978375864 1.697505318215293 1.0 14.135370024947825 -6.475653634173852 1.5568870587823784 1.4694878009974714 1.1947351058828344 0.2268426945297456 0.17606743995106405 0.46535021849953606 2.2862304503311663 0.06655776901734467 0.07612879272724962 3.3446167917803864e-07 6.475653634173852 -0.27475269511463707 VAHEPVAPPEDKESES(ph)EAK ddPTM_A459_Selumetinib_30min_R2 1 VAHEPVAPPEDKESESEAK 19 1 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 VAHEPVAPPEDKES(0.382)ES(0.618)EAK 66.568 0.0094955 5619000.0 36298.0 9709.6 19009.0 26935.0 14227.0 16075.0 56552.0 31948.0 25031.0 15793.0 True False 34280.70247240678 10454.295098715229 17785.981635434317 23266.406534533333 12439.67706900626 18289.18533567889 59181.78005566211 32040.963390723897 30037.89942457562 15337.015054858111 2.2351612976703783 0.681638184569934 1.1596768714001149 1.517010086468131 0.8110885347971215 1.1924866259999958 3.858754773596955 2.0891264223265327 1.9585231752811572 1.0 13.904730107202125 VAHEPVAPPEDKESESEAKVDGETAS(ph)DSESR ddPTM_A459_Selumetinib_30min_R2 1 VAHEPVAPPEDKESESEAKVDGETASDSESR 31 2 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 VAHEPVAPPEDKES(0.132)ES(0.132)EAKVDGET(0.132)AS(0.573)DS(0.025)ES(0.006)R 74.206 1.3865e-05 5634400.0 21017.0 6545.8 14705.0 15300.0 8857.6 6686.8 20130.0 14547.0 9370.1 13316.0 True False 19848.95927771705 7047.841811935626 13758.896309593436 13216.113606027848 7744.829100051301 7607.846003273256 21066.084886838285 14589.329361614506 11244.38182246879 12931.532480877007 1.5349270712554333 0.54501211069592 1.0639803387525744 1.0220067594905458 0.5989103852543587 0.5883174337243978 1.6290478269292952 1.1281980216334784 0.8695320403128434 1.0 13.658605634709396 -7.237566335162835 24.993317388123195 1.1673778332339957 0.8767896696899071 0.13205977460759544 0.3303308303718896 1512.5638031967171 1583545.1408595573 0.12484658626596402 0.09665156182810726 5.7867359362980905e-08 7.237566335162835 -0.29058816354408856 VAHSFNCTPIEGMLSHQLK ddPTM_A459_Selumetinib_30min_R1 1 VAHSFNCTPIEGMLSHQLK 19 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 124.29 0.00021958 10239000.0 2342.4 2575.7 2678.0 2746.1 2770.0 2152.6 2372.4 2072.3 1216.0 1799.4 False True 2396.9733624830246 2274.135846589557 2314.3423092010366 2266.5451856812697 2519.45398908322 2130.9467984044218 2193.4479579698022 2017.33587222093 2063.4631868739225 2030.3705176402643 1.1805595784895622 1.1200595294461828 1.1398620542869238 1.1163209699850705 1.240883852082022 1.049535924546939 1.0803190545334895 0.9935801641591587 1.0162988326249531 1.0 10.987527310193403 -7.212780052564003 1.7344290328747005 1.0088270916341227 1.1519320489154392 0.691665796190923 0.04282102760785967 0.2108615894560944 1.2419250679749296 0.021901229123291215 0.014041939700587128 6.126605937084298e-08 7.212780052564003 0.14310495728131656 VAIEHLDK ddPTM_A459_Selumetinib_30min_R2 2 VAIEHLDK 8 0 E7ENZ3;B7ZAR1;E9PCA1;P48643-2;P48643 E7ENZ3 CCT5 T-complex protein 1 subunit epsilon 0 ; 109.71 0.015757 2558600.0 109328.0 103533.0 109289.0 117614.0 120254.0 92699.0 94983.0 97595.0 85179.0 117440.0 False True 103251.98743466006 111473.64818893524 102257.46472486603 101594.77030453343 105146.61743559991 105467.44581226114 99399.89770524383 97878.98529227797 102217.18010011273 114049.20205423505 0.9053284510097627 0.9774171689156139 0.8966083311677923 0.8907977300553227 0.9219408425637069 0.9247539124570733 0.8715527677078803 0.858217186348507 0.8962551097157548 1.0 16.799296827299706 -5.297971826286093 24.865357736784386 0.9017014262500078 0.9413728425834018 0.08814159651961384 0.04021985426027359 909.3702776293211 618950.1999730901 0.010135612172320844 0.02110028038073539 5.035332731270292e-06 5.297971826286093 0.039671416333393994 VALEFGS(ph)EEPR ddPTM_A459_Selumetinib_30min_R1 1 VALEFGSEEPR 11 0 Q9UNY4 Q9UNY4 TTF2 Transcription termination factor 2 1 VALEFGS(1)EEPR 75.509 0.035152 5552700.0 634.5 1070.4 856.67 1077.8 809.71 825.92 744.71 589.18 398.16 742.66 True False 649.2826154779193 945.0770703845408 740.3389193514759 889.5824628117238 736.4718734659112 817.6119946753591 688.5359251305397 573.5530324736412 675.6484395441786 837.9876451209944 0.7748116804086908 1.127793561023306 0.8834723562595969 1.0615699026007475 0.8788576749954045 0.9756850228469737 0.821654029315819 0.6844409172534133 0.8062749414958544 1.0 9.710785163467767 -7.311791382867279 5.465981248802482 0.7997157668801034 0.9572673407998821 0.19007398832552092 0.11785072028558075 0.26746346879474303 18.72492380358388 0.046640567671515774 0.03146747379846839 4.877627349113411e-08 7.311791382867279 0.1575515739197787 VALHLDEEDKLR ddPTM_A459_Selumetinib_30min_R1 2 VALHLDEEDKLR 12 1 Q16719;B8ZZA3;A0A087X297;Q16719-2;F8WEP1 Q16719 KYNU Kynureninase 0 ; 108.43 0.0064217 30953000.0 19945.1 24348.0 25353.0 26675.0 22139.0 21329.0 20675.0 20868.1 12352.4 16416.7 False True 20409.782023591237 21497.324840921894 21910.201854060433 22016.712001765387 20136.531358957924 21114.449625182508 19115.468104462 20314.61019885805 20961.12061639921 18523.943357199565 1.10180546496104 1.160515578480577 1.1828044078716509 1.1885542714752642 1.087054250310672 1.139846371694724 1.03193298186331 1.0966676914914295 1.131569029995571 1.0 14.177103630215234 -6.687065073096399 1.5923190877042623 1.0762761930456577 1.1579903169683081 0.4045528131658931 0.045194005380253054 0.4020637996692857 2.112414775593282 0.018946383368577176 0.018278791624807667 2.055582571935432e-07 6.687065073096399 0.08171412392265043 VALS(ph)DDETK ddPTM_A459_Selumetinib_30min_R1 2 VALSDDETK 9 0 Q15054-2;H0YD46;Q15054-3;Q15054 Q15054-2 POLD3 DNA polymerase delta subunit 3 1 VALS(1)DDETK;VALS(1)DDETK 125.72 0.0049764 22633000.0 7426.4 9382.1 5135.8 4878.2 5335.1 6602.6 7834.3 7269.9 4068.8 7571.700000000001 True False 7599.420670741084 8283.63937038004 4438.38656893005 4026.3139451550855 4852.541146988406 6536.18383868114 7243.352443568881 7077.078636036734 6904.456426605769 8543.60144960364 0.8894867949503473 0.9695723073276481 0.5194983163845919 0.4712665927718195 0.5679737257890848 0.7650384767169084 0.847810198813162 0.8283484052694262 0.8081435524975342 1.0 13.060628632987713 -7.05960478865377 3.9417250499429493 0.8548246302939407 0.6773854858374937 0.24505236558789967 0.1531404626664814 0.4114127401950044 12.756663968411553 0.06798102083430607 0.053389244598344154 8.717565343147874e-08 7.05960478865377 -0.17743914445644704 VALS(ph)DDETK ddPTM_A459_Selumetinib_30min_R2 4 VALSDDETK 9 0 Q15054-2;H0YD46;Q15054-3;Q15054 Q15054-2 POLD3 DNA polymerase delta subunit 3 1 VALS(1)DDETK;VALS(1)DDETK;VALS(1)DDETK;VALS(0.989)DDET(0.011)K 130.01 0.003947099999999999 60225700.0 239138.0 172893.0 197728.0 201180.0 190761.0 164097.0 247340.0 240729.0 178584.0 163463.0 True False 225847.6673052624 186153.3371613839 185006.39574996912 173778.93694514225 166795.89775502248 186699.87222574803 258841.80009491183 241429.48153516886 214305.7900538693 158743.3984621204 1.422721634368654 1.1726682114960774 1.1654430832543605 1.0947159921526415 1.0507265144309201 1.1761110952295672 1.6305673344688854 1.5208788766909203 1.3500138722619528 1.0 17.27633707133584 -7.149466127166627 10.797394672638845 1.4186528584553575 1.1690328929374822 0.20633329715427473 0.17867682328967108 0.5908380356738681 53.42101960654262 0.06681987714271938 0.05175776320614963 7.088165885026541e-08 7.149466127166627 -0.24961996551787524 VALS(ph)DDETKETENMR ddPTM_A459_Selumetinib_30min_R1 3 VALSDDETKETENMR 15 1 Q15054-2;H0YD46;Q15054-3;Q15054 Q15054-2 POLD3 DNA polymerase delta subunit 3 1 VALS(0.993)DDET(0.007)KETENMR;VALS(0.998)DDET(0.001)KETENMR;VALS(1)DDETKETENMR 128.85 0.0044371 191394000.0 8340.699999999999 10084.2 9340.400000000001 10665.7 8824.9 8338.7 9518.0 8674.6 5512.1900000000005 8476.5 True False 8535.022081822979 8903.53717598261 8072.024983144646 8803.13571498515 8026.689353162644 8254.820248933822 8800.049597014235 8444.52142892808 9353.783835571192 9564.541343101977 0.8923608331703752 0.930890134361112 0.8439531696902806 0.9203928760613327 0.839213200636281 0.8630649346178282 0.9200702136502238 0.8828987325166758 0.9779647031707606 1.0 13.223480072062792 -8.329694681858935 3.504498592314552 0.9992484018384267 0.8860948987163237 0.6531132506768593 0.029974674521125597 0.14136177074331827 3.211780741375794 0.027739441196251404 0.0075525904088664855 4.680640845275263e-09 8.329694681858935 -0.11315350312210293 VALS(ph)DDETKETENMR ddPTM_A459_Selumetinib_30min_R2 2 VALSDDETKETENMR 15 1 Q15054-2;H0YD46;Q15054-3;Q15054 Q15054-2 POLD3 DNA polymerase delta subunit 3 1 VALS(1)DDETKETENMR;VALS(1)DDETKETENMR 106.19 0.0024995 307651000.0 132302.0 111043.0 111613.0 122995.0 119246.0 89156.0 100635.0 90289.0 77640.0 96733.0 True False 124949.18448686879 119559.6410404792 104431.94109504607 106242.86882179049 104265.25140723416 101436.42972241277 105314.72690446944 90551.7260418514 93170.1694428528 93940.06694748247 1.3300946927866475 1.2727225445487433 1.1116868923824499 1.1309643720095062 1.1099124664827418 1.0797994191245486 1.1210842223834694 0.9639308229626308 0.9918043756019455 1.0 16.519453001298935 -1.522878745336643 0.2775044380073545 0.9869850934305977 3.6400267054769904 0.86559015448793 0.04079036831922322 18.52835333334608 0.2606193833617164 0.0488363911876671 23.76184860023528 0.029999999996110558 1.522878745336643 2.6530416120463927 VALSS(ph)ETEVALAR ddPTM_A459_Selumetinib_30min_R2 2 VALSSETEVALAR 13 0 E7EVA0;P27816;P27816-6;P27816-2 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VALS(0.036)S(0.954)ET(0.009)EVALAR;VALS(0.042)S(0.917)ET(0.042)EVALAR 187.62 0.00013374 4531300.0 50959.0 50486.0 57799.0 63125.0 66972.0 45500.0 43303.0 49263.0 41297.0 49810.0 True False 48126.90278503988 54358.11386192395 54080.27526679302 54527.266103301175 58558.378622723554 51767.21199212374 45316.67530326666 49406.3471740713 49557.553934589116 48371.855878077775 0.9949360410389193 1.1237549784927554 1.1180111716842833 1.1272518929341524 1.2105878006897464 1.0701928022485643 0.9368397073184094 1.0213862229847244 1.0245121473011065 1.0 15.561880270129082 -7.006909137317582 24.74281220812233 0.998330914572261 1.1186712182628258 0.522266671076029 0.05372142875425326 227.30478512314514 814019.3023997556 0.01973400169325545 0.01674738002370726 9.842170011756593e-08 7.006909137317582 0.12034030369056481 VANPSGNLTETYVQDR ddPTM_A459_Selumetinib_30min_R1 1 VANPSGNLTETYVQDR 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 160.87 0.00070601 7009900.0 992.25 1154.2 1430.5 1362.1 1272.3 1105.2 1077.1 1262.9 775.28 925.76 False True 1015.3674944175976 1019.0657274269776 1236.2459571740403 1124.2348047836776 1157.2206896428097 1094.0826914413105 995.8534798218149 1229.4037895226613 1315.5935357891565 1044.590313666028 0.9720246120741138 0.9755649790112729 1.1834744597960036 1.0762447153450374 1.1078225353071687 1.047379702001627 0.9533435901074275 1.176924363014648 1.259434936910369 1.0 10.028721515645744 -7.7957982142498805 24.96074415245473 1.1636349047380101 1.0514634180747355 0.20081009937306404 0.08891755586230936 272.3269934945339 197834.59675640997 0.04877874482684596 0.023434293739842852 1.6003014021213532e-08 7.7957982142498805 -0.11217148666327459 VANPSGNLTETYVQDR ddPTM_A459_Selumetinib_30min_R2 2 VANPSGNLTETYVQDR 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 209.56 7.4008e-07 10243000.0 31009.0 31358.5 33794.9 33136.9 36756.4 27146.9 26294.1 26728.2 25043.1 31636.1 False True 29285.643918862246 33763.59611653019 31620.572927105022 28623.597055659084 32138.732425614817 30886.13905997765 27516.827750770695 26805.974636908286 30052.419762677884 30722.683592540776 0.9532254508513237 1.0989793913943027 1.0292256153945565 0.9316763286462602 1.0460913132411989 1.0053203512298827 0.8956518289779726 0.8725141004093979 0.978183421775511 1.0 14.907016618933882 -7.193961213418989 6.880944905934892 0.9261140870527068 1.0140236882003466 0.2911114792251587 0.05565814985323493 0.28269134823533665 24.499319011680175 0.021260590572655384 0.016390690754975207 6.397919723704324e-08 7.193961213418989 0.0879096011476398 VANS(ph)PTMVNLLLGK ddPTM_A459_Selumetinib_30min_R1 2 VANSPTMVNLLLGK 14 0 Q6UB99;A0A2R8Y438;A0A087WTN8 Q6UB99 ANKRD11 Ankyrin repeat domain-containing protein 11 1 VANS(0.5)PT(0.5)MVNLLLGK;VANS(0.5)PT(0.5)MVNLLLGK 128.82 0.0011033 23763500.0 4952.9 6845.0 6548.0 7293.6 6333.799999999999 5526.7 6598.7 5306.4 3546.8999999999996 4496.2 True False 5068.292933334255 6043.584217845833 5658.817565589386 6019.909677828525 5760.908908323217 5471.106415842101 6100.9547463561485 5165.657034383598 6018.830244673616 5073.3310666967645 0.9990069377897332 1.1912457788371376 1.1154047491077357 1.1865793102574076 1.1355278874150299 1.0784051629818685 1.2025540352383246 1.0181982934827367 1.1863665441002778 1.0 12.30871759311008 -11.030519075445872 3.1861860754809896 0.9966283932582489 1.1255229798144013 0.2239022144858911 0.06901488799356827 46851188.34530594 51974109.96017604 1362653.6075271745 0.015822851372378488 9.321395272296444e-12 11.030519075445872 0.12889458655615238 VAPEEHPVLLT(ph)EAPLNPK ddPTM_A459_Selumetinib_30min_R1 2 VAPEEHPVLLTEAPLNPK 18 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 VAPEEHPVLLT(1)EAPLNPK;VAPEEHPVLLT(1)EAPLNPK 163.62 6.129600000000001e-06 33408000.0 16990.3 20641.3 20227.9 22864.0 19878.6 17192.699999999997 18719.0 23472.8 10031.5 14870.7 True False 17386.140932631202 18224.60700011997 17481.06228390128 18871.23161043537 18080.58413985188 17019.757047722615 17307.010759246645 22850.225093600053 17022.722828228412 16779.49919788434 1.036153744971325 1.086123416747613 1.041810728541016 1.1246600025354017 1.0775401534112286 1.0143185351961261 1.0314378608766117 1.3617942242567733 1.0144952854358573 1.0 14.03441203719187 VAPEEHPVLLT(ph)EAPLNPK ddPTM_A459_Selumetinib_30min_R2 2 VAPEEHPVLLTEAPLNPK 18 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 VAPEEHPVLLT(1)EAPLNPK;VAPEEHPVLLT(1)EAPLNPK 182.22 1.2673000000000002e-09 27790000.0 113175.0 101197.0 108710.0 103205.0 95285.0 78886.0 88932.0 83457.0 82386.0 92564.0 True False 106885.18657542125 108958.48450035902 101715.71695449858 89148.30096144481 83314.44644129204 89751.83044419053 93067.51421541482 83699.84605294986 98865.50205717275 89891.4368098453 1.1890474818143604 1.2121119471129136 1.131539561100421 0.9917329628408043 0.9268340722769166 0.9984469447746165 1.0353323688916902 0.9311214618808127 1.0998322595100023 1.0 16.455896068588558 -5.63300634821812 3.245400657981158 0.992895569139753 1.1970517685723923 0.7621236075737643 0.046981610069268306 0.10698408677766202 2.215928497639156 0.012936300590100038 0.02452556206721492 2.3280572274764905e-06 5.63300634821812 0.2041561994326393 VAPEEHPVLLTEAPLNPK ddPTM_A459_Selumetinib_30min_R1 2 VAPEEHPVLLTEAPLNPK 18 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ; 246.34 1.3622e-32 703960000.0 14435.8 12848.7 13744.2 15234.7 15778.5 14830.7 13243.4 13227.8 9153.2 12745.4 False True 14772.126052822925 11344.368230801427 11877.813131486519 12574.245635737394 14351.337460920437 14681.516623198208 12244.439675677497 12876.955774050082 15532.311876722353 14381.396240709239 1.0271691152634854 0.7888224509584866 0.8259151568235177 0.8743410879775104 0.9979098844586651 1.0208686540211875 0.851408268761646 0.895389818799335 1.0800280874505934 1.0 13.811916128467187 -6.242700541497943 19.433876468878346 0.9652239937729088 0.8688197622173254 0.23012729758687966 0.08350464493425676 72.42766391473036 75111.24808846095 0.024995329622324036 0.0321258891299419 5.718728234693978e-07 6.242700541497943 -0.09640423155558342 VAPEEHPVLLTEAPLNPK ddPTM_A459_Selumetinib_30min_R2 6 VAPEEHPVLLTEAPLNPK 18 0 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;K7EM38;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 ;;;;; 259.08 2.1891e-42 339898300.0 961519.0 817122.0 992522.0 1042088.0 1086833.0 766337.0 850170.0 866223.0 747536.0 881784.0 False True 908081.6232455254 879792.6299386574 928664.2150962446 900153.8166979306 950295.322129704 871892.9656353437 889704.5895798965 868743.5655190636 897064.0879009872 856324.6047700255 1.0604408867702684 1.0274055247716893 1.084476855999772 1.0511829412395266 1.109737261823646 1.0181804432321542 1.0389805275054962 1.014502632155914 1.0475748132238976 1.0 19.707798253447613 -6.831662957470697 24.99999270129756 1.0256997168182678 1.064602695593786 0.45181253975753655 0.023474405152266783 48.23525717135583 17171.0178662829 0.00802604315625959 0.007078305363032327 1.4734555621661166e-07 6.831662957470697 0.03890297877551818 VAPGPSSGSTPGQVPGSSALS(ph)SPRR ddPTM_A459_Selumetinib_30min_R2 2 VAPGPSSGSTPGQVPGSSALSSPRR 25 1 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-5 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 VAPGPSSGSTPGQVPGS(0.065)S(0.195)ALS(0.37)S(0.37)PRR;VAPGPSSGSTPGQVPGS(0.041)S(0.118)ALS(0.493)S(0.348)PRR 100.14 2.0041e-06 12799700.0 11339.900000000001 13739.2 12544.2 14345.5 13697.9 9398.0 9508.8 9578.0 7780.4 10860.3 True False 10709.673755216412 14792.95246150906 11737.119829092284 12391.618152632193 11977.04734122028 10692.489193450092 9950.978041329749 9605.870394276735 9336.697402539587 10546.73492055186 1.015449220625337 1.4026096771127547 1.1128676237250246 1.1749245852842387 1.1356166084994936 1.0138198479431022 0.9435126715794105 0.9107909193354512 0.8852689929985499 1.0 13.364508815164573 -6.831227198369406 1.49233584071677 0.921431490114899 1.1928207562211512 0.5799551235491496 0.09462835615883995 0.2578192734036241 1.191280278707991 0.04184230976466092 0.03576022962389679 1.4749347287790756e-07 6.831227198369406 0.27138926610625225 VAPGPSSGSTPGQVPGSSALSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 VAPGPSSGSTPGQVPGSSALSSPR 24 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-5 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 VAPGPSSGSTPGQVPGS(0.015)S(0.018)ALS(0.357)S(0.611)PR;VAPGPSSGSTPGQVPGSS(0.001)ALS(0.097)S(0.901)PR 146.34 1.9525e-09 11399000.0 19215.2 13652.9 17841.9 19498.9 18741.6 13943.5 16664.4 19153.2 18256.4 15317.5 True False 18147.296108540155 14700.033529007282 16693.971578791916 16843.116182521328 16387.112655970188 15864.090558509388 17439.32761988215 19208.932641017043 21908.19012643612 14875.243975355483 1.2199662834845355 0.9882213396540938 1.1222653965507796 1.1322917600831361 1.10163656361667 1.0664759909008668 1.172372543857076 1.2913356360972221 1.472795347944037 1.0 13.860625710433824 -7.6008642876921835 3.6177019177884775 1.2856547155524254 1.1023718699518488 0.22217190145806387 0.12098579838480794 0.27653699965093975 7.1722135815634145 0.058606485463098365 0.03197848943333018 2.5068925073224612e-08 7.6008642876921835 -0.18328284560057662 VAPPYPHLFS(ph)SCSPPGMVLDGSPK ddPTM_A459_Selumetinib_30min_R2 1 VAPPYPHLFSSCSPPGMVLDGSPK 24 0 Q9BUK6-2;Q9BUK6;V9GYF2;Q9BUK6-6;Q9BUK6-5 Q9BUK6-2 MSTO1 Protein misato homolog 1 1 VAPPYPHLFS(0.756)S(0.142)CS(0.099)PPGMVLDGS(0.003)PK 89.859 3.9783e-05 2955600.0 45142.0 38975.0 45075.0 49661.0 48418.0 34902.0 40727.0 42301.0 37861.0 45812.0 True False 42633.18835774383 41964.25717562267 42174.92357394926 42897.08612999664 42335.29797758805 39709.43369118907 42620.88619901949 42424.08890669245 45434.25792472764 44489.28852612927 0.9582798415107195 0.9432440608929133 0.9479792770607975 0.9642115563345658 0.9515840639421297 0.8925616706112773 0.9580033219454064 0.9535798461190519 1.02124038009831 1.0 15.441170406630638 -8.1891224778552 4.670827300916388 1.010591399004811 0.9449309933073619 0.6377752577301229 0.019457225102304087 0.13245048628510145 5.3312185762271875 0.015026661855018606 0.005180157772211548 6.469601371135404e-09 8.1891224778552 -0.06566040569744913 VAPPYPHLFSSCSPPGMVLDGS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 VAPPYPHLFSSCSPPGMVLDGSPK 24 0 Q9BUK6-2;Q9BUK6;V9GYF2;Q9BUK6-6;Q9BUK6-5 Q9BUK6-2 MSTO1 Protein misato homolog 1 1 VAPPYPHLFS(0.008)S(0.008)CS(0.001)PPGMVLDGS(0.983)PK 62.683 0.0033493000000000004 11168000.0 1535.5 2146.1 2258.3 2779.3 2074.2 1916.4 2015.8 2058.9 555.05 1676.5 True False 1571.2741624371083 1894.833614305178 1951.6352639539582 2293.9474289224554 1886.5889762297525 1897.1227559519807 1863.7465830701087 2004.2912837502624 941.8793107519493 1891.6951054928866 0.8306170259015965 1.0016590986587521 1.0316859510219296 1.2126412032581544 0.9973007651982037 1.002869199398642 0.9852256728150196 1.059521313942417 0.49790228246456236 1.0 10.885463865284652 -8.225092697092068 24.99900889768655 0.7489508015486812 1.0198647820916802 0.35799917999212905 0.14250272151787136 503.93547580726766 346604.49340464815 0.09115131277128757 0.0344497570974048 5.955350172160336e-09 8.225092697092068 0.270913980542999 VAPVINNGS(ph)PTILGK ddPTM_A459_Selumetinib_30min_R1 2 VAPVINNGSPTILGK 15 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 VAPVINNGS(0.994)PT(0.006)ILGK;VAPVINNGS(0.997)PT(0.003)ILGK 161.48 0.00012007 284720000.0 11493.8 14287.3 14355.099999999999 16477.7 13610.4 12266.0 13029.2 11718.7 6080.2 11180.0 True False 11761.583176958402 12614.536274014425 12405.75626692001 13600.179019737176 12379.341723111283 12142.615176636922 12046.396954130905 11407.88200829774 10317.655319762187 12615.061902421998 0.9323444679015223 0.9999583332676732 0.9834082751934969 1.0780905496092763 0.9813143858401949 0.9625489966327974 0.9549217472978144 0.9043064629042773 0.8178838438978467 1.0 13.622859665221421 -7.411875660898251 1.685215617740934 0.8969864642763299 0.9969535474050667 0.31520188758184253 0.053768991299714845 0.4061542028289781 2.2423450815842823 0.03213092838639137 0.017300950555241196 3.873685331858396e-08 7.411875660898251 0.09996708312873681 VAPVINNGS(ph)PTILGK ddPTM_A459_Selumetinib_30min_R2 2 VAPVINNGSPTILGK 15 0 H0Y4T7;E7ESY4;Q13330-3;Q13330;F8W9Y9 H0Y4T7 MTA1 Metastasis-associated protein MTA1 1 VAPVINNGS(0.998)PT(0.002)ILGK;VAPVINNGS(0.961)PT(0.039)ILGK 198.61 2.4648e-05 245560000.0 104595.0 114839.0 123381.0 115978.0 120203.0 83210.0 95732.0 105406.0 72172.0 99253.0 True False 98782.02862695987 123646.78203441523 115442.80078707595 100181.59632679084 105102.02451154574 94671.42219482684 100183.72768935925 105712.71400909741 86608.41665416787 96387.30799973593 1.024844771338883 1.2828118618558575 1.1976971157591851 1.0393650202064497 1.090413527389246 0.9821980109153604 1.0393871326879853 1.0967493148515677 0.8985458609800073 1.0 16.556555568625683 -5.790765699667206 6.920375380638497 1.0265074898620412 1.180027906115609 0.41597044930107396 0.07957334571582662 0.157435041983792 25.10045453263709 0.021591457772523838 0.03304542533049727 1.6189532216036197e-06 5.790765699667206 0.15352041625356772 VAQGATEKS(ph)PEDK ddPTM_A459_Selumetinib_30min_R1 3 VAQGATEKSPEDK 13 1 P49321-4;P49321;P49321-3 P49321-4 NASP Nuclear autoantigenic sperm protein 1 VAQGATEKS(1)PEDK;VAQGAT(0.002)EKS(0.998)PEDK;VAQGAT(0.019)EKS(0.981)PEDK 144.41 0.0044925 3952200.0 2280.21 2681.81 1875.71 1859.37 1636.9 2033.9299999999998 2026.79 2103.24 1367.13 2440.6 True False 2333.3344564836984 2367.822438460355 1620.9988845375183 1534.6659341976556 1488.8426840181683 2013.4705108606804 1873.90759852201 2047.4552429136445 2319.919758775449 2753.874783457166 0.8472914129939022 0.85981485167159 0.5886247603830936 0.55727513226693 0.5406355775367176 0.7311409084232235 0.6804621654473118 0.7434816046150454 0.8424202046917553 1.0 11.42724724740573 -8.478480833774436 1.345173114353833 0.9987900308959077 0.6788147180511673 0.47904235229311465 0.10299729015778629 0.42455045654632456 1.6819534500858278 0.1098674825218302 0.03343588023979259 3.322914495289737e-09 8.478480833774436 -0.31997531284474034 VAQGATEKS(ph)PEDKVQIAANEETQER ddPTM_A459_Selumetinib_30min_R2 2 VAQGATEKSPEDKVQIAANEETQER 25 2 P49321-4;P49321;P49321-3 P49321-4 NASP Nuclear autoantigenic sperm protein 1 VAQGAT(0.043)EKS(0.957)PEDKVQIAANEETQER;VAQGAT(0.013)EKS(0.987)PEDKVQIAANEETQER 97.049 7.2525e-06 14225600.0 21479.2 16326.2 15084.900000000001 16962.8 15223.9 14480.1 14309.3 15480.099999999999 9835.8 15010.5 True False 20285.472052050245 17578.367042992977 14114.353957197276 14652.437377537846 13311.33757860719 16474.60233773959 14974.71080334004 15525.144528131485 11803.234835213982 14577.107863037274 1.391597856217247 1.2058885211082169 0.968254751889887 1.005167658441465 0.9131672553758309 1.1301694748046514 1.0272758453898085 1.0650359916385141 0.8097103311654216 1.0 13.831416893072937 -4.993728515357042 2.49306112400274 0.9958534656062689 1.40527379619045 0.7126032831812202 0.08231931982513728 0.186122520611342 1.9830129600451551 0.021670302420004634 0.13410056107535612 1.0145453966098594e-05 4.993728515357042 0.40942033058418115 VAQQPLSLVGCEVVPDPSPDHLY(ph)SFR ddPTM_A459_Selumetinib_30min_R2 1 VAQQPLSLVGCEVVPDPSPDHLYSFR 26 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 VAQQPLSLVGCEVVPDPS(0.001)PDHLY(0.735)S(0.264)FR 149.07 4.5360000000000007e-10 2503800.0 8658.7 7327.0 13069.0 14488.0 14810.0 10611.0 8285.2 8895.7 9731.4 13912.0 True False 8177.484117522409 7888.957339981721 12228.154768451315 12514.709406805978 12949.43539692014 12072.568932932412 8670.478216812347 8921.585014237586 11677.951918034247 13510.324412283037 0.6052766660501337 0.5839206446300729 0.9050970498779419 0.9263070985496183 0.9584844154554159 0.8935809803320877 0.6417668408413274 0.6603531300940816 0.8643724282014374 1.0 13.72177469687572 -5.2541279335256315 24.386226472880704 0.8439420832103708 0.5945986050507229 0.4628995201576397 0.11211027969501033 405.8392724730125 1353603.249181014 0.03195674678552789 0.08084403726998123 5.570216385364811e-06 5.2541279335256315 -0.24934347815964786 VAQQPLSLVGCEVVPDPSPDHLYS(ph)FR ddPTM_A459_Selumetinib_30min_R2 1 VAQQPLSLVGCEVVPDPSPDHLYSFR 26 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 VAQQPLSLVGCEVVPDPSPDHLY(0.42)S(0.58)FR 165.0 1.6528999999999999e-15 3567400.0 6933.9 6201.4 13136.0 12363.0 14132.0 8679.7 8571.3 6753.1 7888.7 9529.5 True False 6548.541596600949 6677.0274393561685 12290.844061395404 10679.138072635447 12356.611818317038 9875.249888528273 8969.882433708743 6772.750402964116 9466.660428694413 9254.358574385515 0.7076170156974676 0.7215008350591732 1.328114094845467 1.1539576715984918 1.3352207739732531 1.0670917718556183 0.9692603070877162 0.7318443897030242 1.0229407422029781 1.0 13.175917284091078 -7.430424116148315 4.480586465191126 0.8986431591505372 1.0660522282584803 0.07054362938135372 0.21221293821670703 0.5776426229751217 19.89159374347514 0.10279798112585911 0.06647137556723133 3.711725784502581e-08 7.430424116148315 0.16740906910794318 VAQRS(ph)PVDSGTILR ddPTM_A459_Selumetinib_30min_R1 2 VAQRSPVDSGTILR 14 1 P49454 P49454 CENPF Centromere protein F 1 VAQRS(0.858)PVDS(0.139)GT(0.003)ILR;VAQRS(0.985)PVDS(0.011)GT(0.003)ILR 148.18 0.0022043 17807000.0 3067.7 3030.6000000000004 3191.8 3483.6000000000004 3171.3 2593.4 3177.2 2778.6000000000004 1615.8200000000002 2496.0 True False 3139.171441294897 2675.7759431122836 2758.371091302413 2875.2546552708473 2884.4564749384917 2567.312750618799 2937.541246021605 2704.902501835195 2741.9285251764977 2816.385913098866 1.114609836207024 0.9500743242136624 0.9794009686220099 1.0209022285966514 1.024169472487074 0.911562843244727 1.0430180155209738 0.9604161451223118 0.9735627892555241 1.0 11.459629316353118 -4.751738387787808 24.998705706206795 0.9852746887620988 1.1146100947033533 0.5236601819213664 0.03714212734811972 314.82057053611925 811211.9770060282 0.008943837942323021 0.11473683375231052 1.7711755655262102e-05 4.751738387787808 0.12933540594125448 VAS(ph)DTEEADR ddPTM_A459_Selumetinib_30min_R2 2 VASDTEEADR 10 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 VAS(0.879)DT(0.121)EEADR;VAS(0.944)DT(0.056)EEADR 143.0 0.0011383 17665100.0 37541.0 36700.0 45621.0 41687.0 50349.0 38038.0 33947.0 39026.0 37455.0 40394.0 True False 35454.62150853002 39514.77199090063 42685.794528389124 36009.15868591393 44023.70849422904 43277.38922541547 35525.60276470435 39139.55919889789 44947.046580139824 39227.72026378388 0.903815497564428 1.0073175735216446 1.08815384226643 0.9179518576091862 1.122260182294431 1.1032348791721747 0.9056249643317299 0.9977525825030577 1.145798080487389 1.0 15.259585874543824 -4.791337863796793 3.9029690000373005 1.0326157190415157 0.8929940278615667 0.20237963103429957 0.07780647056042782 0.386249040286659 10.725537162061695 0.01951984551348181 0.15052928979880964 1.616821725389136e-05 4.791337863796793 -0.13962169117994905 VAS(ph)DTEEADRTSSK ddPTM_A459_Selumetinib_30min_R1 2 VASDTEEADRTSSK 14 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 VAS(0.995)DT(0.005)EEADRTSSK;VAS(0.944)DT(0.056)EEADRTSSK 201.08 0.00029793 14097800.0 2816.3 2238.7 4368.4 4597.5 3486.8 3257.7 2809.7 2556.1000000000004 1789.8600000000001 2113.58 True False 2881.9143104341438 1976.5919632566054 3775.1952739035864 3794.6329307634965 3171.41955564454 3224.9304957549402 2597.762066897552 2488.3039246170506 3037.2616937978296 2384.87858101262 1.2084113352263335 0.8288019268542149 1.5829716883534748 1.5911220642320056 1.32980336227346 1.3522409574350884 1.0892638675946937 1.0433671317390574 1.2735498226111819 1.0 11.219700102242966 -7.264369625569826 24.44080656813549 1.1051591205692908 1.318761504417817 0.1993786133584705 0.2099886725646421 365.31491782715074 3047011.1877254453 0.09277813657935832 0.06564234845383747 5.440394268759706e-08 7.264369625569826 0.21360238384852615 VAS(ph)DTEEADRTSSK ddPTM_A459_Selumetinib_30min_R2 1 VASDTEEADRTSSK 14 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 VAS(0.842)DT(0.131)EEADRT(0.011)S(0.011)S(0.004)K 67.415 0.036481 8418600.0 25805.0 37366.0 32244.0 36523.0 32460.0 18389.0 13775.0 15478.0 10827.0 31166.0 True False 24370.861405599655 40231.85204937313 30169.456144612755 31548.504394310785 28382.08460391813 20921.91783127832 14415.564794644664 15523.03841747916 12992.70253165597 30266.156601007282 0.8052182418427245 1.329268614437625 0.9968049971567481 1.0423690331814652 0.937749876142964 0.6912644412400225 0.47629320711850487 0.5128843619662808 0.4292815471398031 1.0 14.885417863280674 -6.748926873493557 2.216437136213598 0.56318773766976 1.0592697859870739 0.5283077569281871 0.19035467782579996 0.20895804203742804 2.10913319857288 0.07012212547004874 0.06517403626297996 1.7826789096597034e-07 6.748926873493557 0.49608204831731384 VAS(ph)LPGDFK ddPTM_A459_Selumetinib_30min_R2 1 VASLPGDFK 9 0 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2;A8MXE8;Q7Z5J4-4 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 VAS(1)LPGDFK 82.417 0.041393 1353800.0 20329.0 18022.0 20045.0 20217.0 24105.0 16780.0 22916.0 22624.0 17677.0 16904.0 True False 19199.195563434812 19404.229450136558 18755.326523345822 17463.409723729736 21076.71439856582 19091.292686326073 23981.639407192546 22689.832094395184 21212.89393664749 16415.93759813345 1.169546085848781 1.1820360143390707 1.1425071770179225 1.0638082424067807 1.2839177946779181 1.1629730298497736 1.4608754001306234 1.382183135063519 1.2922133633755695 1.0 14.002809531504074 -6.7114217122396305 1.8853716170215713 1.3071137164933622 1.1480748022294978 0.1370550679174164 0.12439073593017597 0.48778387325714906 3.5743516143053453 0.04832087781791604 0.045877425232265096 1.9434719987369346e-07 6.7114217122396305 -0.1590389142638644 VAS(ph)LTLHNK ddPTM_A459_Selumetinib_30min_R1 1 VASLTLHNK 9 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 VAS(0.994)LT(0.006)LHNK 76.332 0.037582 7266200.0 1715.0 1980.5 2723.9 2181.4 2019.6 2549.0 1790.3 2095.2 1326.7 1594.8 True False 1754.956163190909 1748.6221392905281 2354.0093413116883 1800.4594399494279 1836.927536589339 2523.3593743068227 1655.2562296212018 2039.6284898312447 2251.313001665816 1799.508114667496 0.9752421502779279 0.9717222862391091 1.3081404424489913 1.0005286585118331 1.0207942501713905 1.4022495112632911 0.9198381580663512 1.1334366726143477 1.25107132516699 1.0 10.813386892600837 -5.113798243369175 21.316881032073553 1.1288358817936714 0.9732937802208897 0.1562553925614033 0.14501403745055014 11.490963230563013 2117.204541340584 0.0355261347583655 0.09399397546814461 7.69487831925325e-06 5.113798243369175 -0.1555421015727817 VAS(ph)LTLHNK ddPTM_A459_Selumetinib_30min_R2 1 VASLTLHNK 9 0 Q9P0K7;Q9P0K7-3;Q9P0K7-2;Q9P0K7-4 Q9P0K7;Q9P0K7-4 RAI14 Ankycorbin 1 VAS(0.982)LT(0.018)LHNK 81.017 0.029728 6956500.0 52395.0 47447.0 50424.0 54268.0 63975.0 42111.0 45469.0 45910.0 40137.0 57899.0 True False 49483.09565380333 51086.03233384911 47179.77473750013 46876.604782478375 55937.88855624343 47911.40800440268 47583.398595114224 46043.59049919035 48165.52152148105 56227.305430331755 0.880054544230564 0.9085626981920213 0.8390900893509482 0.8336982258657347 0.9948527344166096 0.8521021528190985 0.8462685208003123 0.81888310575794 0.8566215498475269 1.0 15.778983290105122 -5.169499878573554 22.4588410517665 0.8739222543173053 0.8943081705656495 0.00012091331759445101 0.061908761359824684 152.52250025184733 37241.7289834123 0.01555917143113935 0.04116568638146328 6.768619821667585e-06 5.169499878573554 0.020385916248344182 VAS(ph)PLDQNGSFNVVIK ddPTM_A459_Selumetinib_30min_R2 2 VASPLDQNGSFNVVIK 16 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 VAS(1)PLDQNGSFNVVIK;VAS(1)PLDQNGSFNVVIK 179.66 1.0536e-06 16208400.0 89303.0 78419.0 95583.0 92026.0 99108.0 78743.0 80277.0 94749.0 83186.0 83031.0 True False 84339.8967682335 84433.48514317283 89433.29384290158 79491.90004629525 86657.16700323834 89589.13349221535 84010.03956585778 95024.70390345858 99825.52441104023 80633.67928955391 1.0459636408921718 1.0471243019926437 1.1091307581506784 0.985839921316767 1.0747018834655206 1.1110634449719525 1.0418728291459878 1.1784741157876077 1.2380127670048242 1.0 16.299094932883676 -7.760134364651948 24.99925229484976 1.1561825936279868 1.0605750197454429 0.2229020775024939 0.06559110491339494 41.08815765403559 787150.1385150702 0.031242130943815713 0.01676699972298205 1.737263260586998e-08 7.760134364651948 -0.09560757388254393 VAS(ph)PSQGQVGSSS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 1 VASPSQGQVGSSSPKR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 2 VAS(0.975)PS(0.025)QGQVGS(0.001)S(0.025)S(0.974)PKR 123.54 0.0045661 4576200.0 33932.0 27492.0 27450.0 31223.0 26360.0 17926.0 29250.0 23502.0 20128.0 27537.0 True False 32046.195280558324 29600.547999287206 25683.89688530024 26970.373537320746 23048.421138610054 20395.143783973846 30610.182957775443 23570.38692903446 24154.162423309415 26741.935260281633 1.1983498938521038 1.1068962553077195 0.9604352353454075 1.0085423240620286 0.8618830654654468 0.7626652142212633 1.1446510007538278 0.8814016898785293 0.9032316542619225 1.0 14.706816253708588 -5.043645737916242 1.3512522741331765 0.9282556076298839 1.2505927304091873 0.45514753158654087 0.09601768784197515 0.7608944277712129 1.7354595995588984 0.029214306064548445 0.2959617458848679 9.043868981241471e-06 5.043645737916242 0.3223371227793034 VAS(ph)PTSGVK ddPTM_A459_Selumetinib_30min_R1 2 VASPTSGVK 9 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 VAS(0.526)PT(0.366)S(0.109)GVK;VAS(0.46)PT(0.46)S(0.079)GVK 83.86200000000002 0.037731 89293000.0 15565.8 18189.4 15092.099999999999 16564.300000000003 14602.1 12799.8 16452.6 14259.2 7068.3 12099.7 True False 15928.452854225678 16059.776591977363 13042.675714971221 13671.655955420523 13281.342633210135 12671.045633288535 15211.56713593575 13880.999695590732 11994.388851793548 13652.814356058632 1.166679077208517 1.1762978806527613 0.9553104125511929 1.0013800524104783 0.9727915642034896 0.928090377766367 1.114170803119827 1.016713428717416 0.8785286710113996 1.0 13.736910754798226 -5.256338494664866 24.914655887895034 0.9869322184550955 1.1714885041499026 0.6249663912404284 0.058237390777718 257.23323567191267 1256413.3777484398 0.015190656855663252 0.03767558832603284 5.5419359901444375e-06 5.256338494664866 0.1845562856948071 VAS(ph)PTSGVK ddPTM_A459_Selumetinib_30min_R2 2 VASPTSGVK 9 0 Q9Y4H2 Q9Y4H2 IRS2 Insulin receptor substrate 2 1 VAS(0.985)PT(0.011)S(0.003)GVK;VAS(0.719)PT(0.216)S(0.065)GVK 91.469 0.027177 166975000.0 920990.0 770670.0 829940.0 888720.0 823760.0 656820.0 760700.0 776530.0 588967.0 687360.0 True False 869805.0628150839 829777.9109053792 776542.5639703497 767674.8028724897 720271.9042921627 747290.992981686 796074.0572984548 778789.5737385376 706776.8571129421 667514.1308242435 1.3030511604916175 1.243086659275322 1.1633350188579203 1.1500502647405655 1.0790361896950018 1.1195133682921954 1.1925950635913372 1.1667012543642958 1.0588193185366985 1.0 19.34843885244191 -1.5228787452803376 0.4299080252162994 1.1013170713680862 5.289038178077621 0.6420752767275453 0.05044056328110231 56.8499190115313 0.714630014541255 0.034478823761506475 206.19156600725947 0.029999999999999995 1.5228787452803376 4.187721106709534 VAS(ph)SPAPPEGPSHPR ddPTM_A459_Selumetinib_30min_R1 2 VASSPAPPEGPSHPR 15 0 H7BYJ3;O14578;O14578-4;O14578-3 H7BYJ3 CIT Citron Rho-interacting kinase 1 VAS(0.567)S(0.433)PAPPEGPSHPR;VAS(0.579)S(0.421)PAPPEGPSHPR 128.99 0.00060999 34442000.0 3653.8 4267.0 3315.4 3686.7 4207.4 3021.5 3737.2 3753.8 1845.31 3617.4 True False 3738.9264309428218 3767.417656325517 2865.186890188615 3042.887052930024 3826.8414128768036 2991.106453302498 3455.299995163018 3654.23702993916 3131.356293890063 4081.7285264598695 0.9160154593097439 0.9229956455710302 0.7019542999038265 0.7454898171704611 0.9375541239622488 0.7328038682417518 0.8465286147189803 0.895267043423028 0.7671642720947747 1.0 11.99496451736243 -11.147112346060297 2.7289839071443818 1.0161305140585608 0.8288209654363466 0.2745839492878215 0.083116397642564 65788071.56774882 60825574.87564665 7522478.45285424 0.02074934157244195 7.126686486178257e-12 11.147112346060297 -0.18730954862221416 VAS(ph)SPAPPEGPSHPR ddPTM_A459_Selumetinib_30min_R2 2 VASSPAPPEGPSHPR 15 0 H7BYJ3;O14578;O14578-4;O14578-3 H7BYJ3 CIT Citron Rho-interacting kinase 1 VAS(0.556)S(0.444)PAPPEGPSHPR;VAS(0.571)S(0.429)PAPPEGPSHPR 89.87700000000002 0.010678 40045000.0 43092.0 43409.0 56270.0 54530.0 64387.0 49592.0 46463.0 46234.0 43539.0 51908.0 True False 40697.11915094367 46738.33071806555 52649.649462143694 47102.91993050319 56298.12943291676 56422.847848646175 48623.6215646879 46368.53328554925 52248.01658130311 50409.28116681912 0.8073338521980693 0.9271770919207255 1.0444435676023733 0.9344096729851351 1.116820714951473 1.1192948310833157 0.9645767691822077 0.9198411921824903 1.0364761284414883 1.0 15.621401761302808 -4.873234780731402 2.2227414249276616 1.0170028017385706 0.7745987653079395 0.5074921716156265 0.06428538016242037 0.44763359677114295 3.0608912353219457 0.018391799495690482 0.20182360155826368 1.3389526504349211e-05 4.873234780731402 -0.24240403643063113 VASDT(ph)EEADR ddPTM_A459_Selumetinib_30min_R1 2 VASDTEEADR 10 0 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 VAS(0.333)DT(0.667)EEADR;VAS(0.085)DT(0.915)EEADR 133.91 0.0051231 7187200.0 2758.6 3597.4 2378.6000000000004 2605.2 3162.3 2183.8 2725.8 2441.3 1340.23 2605.3999999999996 True False 2822.8700126987997 3176.214735614113 2055.5991847145565 2150.2507256607005 2876.2705233494125 2161.8329547317558 2520.190711445831 2376.548793540007 2274.2724234737157 2939.8284687451046 0.9602158910665186 1.0804081834644972 0.6992241916726556 0.731420471813635 0.9783803898521936 0.7353602353726971 0.8572577407965573 0.8083970948667154 0.7736071841104769 1.0 11.521516264720262 -5.25142471936929 24.997864050005752 0.8164913508946172 1.020312049085846 0.38685172470574425 0.09911809402684185 647.0532358189495 1615119.6370937936 0.02411304346962308 0.06220491749466644 5.6049956597137965e-06 5.25142471936929 0.20382069819122872 VASEAPLEHKPQVEAS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 VASEAPLEHKPQVEASSPR 19 1 Q8TD19 Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 1 VASEAPLEHKPQVEAS(0.636)S(0.364)PR 110.34 0.00036284 54113000.0 2104.0 2419.4 2504.4 2646.5 2838.6 2213.0 2484.2 2380.7 1096.3 1488.6 True False 2153.0191063286716 2136.135523251456 2164.316235684493 2184.3384559577166 2581.849131195536 2190.739229243232 2296.8147939591067 2317.556102396547 1860.341029416021 1679.6763101918946 1.2818059606274377 1.2717542721117578 1.2885317382592787 1.300452023228313 1.537111118094279 1.3042627415474777 1.3674151263684293 1.379763522491889 1.107559247057242 1.0 10.713967523217093 -8.407740845360125 3.592567927565901 1.0039266753034852 1.3419602970579596 0.7106516800258852 0.07469756426619117 0.12410346165823553 2.777580362335025 0.07535327945076388 0.019980125088115894 3.910741901640143e-09 8.407740845360125 0.3380336217544744 VASEAPLEHKPQVEAS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 6 VASEAPLEHKPQVEASSPR 19 1 Q8TD19 Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 1 VASEAPLEHKPQVEAS(0.5)S(0.5)PR;VASEAPLEHKPQVEAS(0.5)S(0.5)PR;VASEAPLEHKPQVEAS(0.5)S(0.5)PR;VASEAPLEHKPQVEAS(0.5)S(0.5)PR;VASEAPLEHKPQVEAS(0.737)S(0.263)PR;VASEAPLEHKPQVEAS(0.5)S(0.5)PR 95.361 0.00095315 217101700.0 261352.0 218107.0 259641.0 329781.0 317545.0 224080.0 238396.0 248838.0 185950.0 271780.0 True False 246827.10211495 234835.10557545995 242935.98073574642 284864.25889604335 277652.1582116815 254944.98600428738 249481.88637271247 249562.07738265124 223145.1958771064 263933.0052307569 0.9351884653423652 0.8897527058813406 0.9204456279476955 1.079305176883756 1.051979679346772 0.9659458307663671 0.9452470188584039 0.9455508497865164 0.8454615052104238 1.0 18.00981224762981 -10.55092125587264 13.815593226879793 0.9999836823305943 0.956907582647785 0.04110240769191831 0.06564884524251083 0.0 0.0 0.06971370497948047 0.01690805701079682 2.812410716572968e-11 10.55092125587264 -0.04307609968280934 VASETHS(ph)EGSEYEELPK ddPTM_A459_Selumetinib_30min_R1 2 VASETHSEGSEYEELPK 17 0 Q5JSZ5;A0A494C0D3 Q5JSZ5 PRRC2B Protein PRRC2B 1 VASETHS(1)EGSEYEELPK;VASETHS(1)EGSEYEELPK 169.58 6.5714e-07 13131900.0 5365.1 6328.799999999999 7579.3 8088.1 8376.5 5633.9 6993.4 6657.5 1600.56 4578.6 True False 5490.096391332683 5587.821153820699 6550.072690114792 6675.665167440617 7618.847053991186 5577.228081171913 6465.882207581361 6480.921473392289 2716.0334197227994 5166.307909340734 1.0626730902752692 1.081588873887649 1.267844039700421 1.2921539491231155 1.4747179586830739 1.0795384593876474 1.251547976049005 1.2544590038225791 0.5257203920835196 1.0 12.334917914575808 -8.244381877230543 24.619538494296325 0.762860204759246 1.2246987360715107 0.571904131988602 0.15836753725280772 398.00101961508403 574447.8719589479 0.10613082353648526 0.03987540994653429 5.696631444431997e-09 8.244381877230543 0.4618385313122647 VASETHS(ph)EGSEYEELPK ddPTM_A459_Selumetinib_30min_R2 4 VASETHSEGSEYEELPK 17 0 Q5JSZ5;A0A494C0D3 Q5JSZ5 PRRC2B Protein PRRC2B 1 VASET(0.006)HS(0.993)EGSEYEELPK;VASETHS(0.999)EGS(0.001)EYEELPK;VASETHS(0.999)EGS(0.001)EYEELPK;VAS(0.011)ET(0.041)HS(0.948)EGSEYEELPK 136.85 0.00033931 22961400.0 197368.0 168649.0 250594.0 267381.0 263701.0 154836.0 165671.0 186465.0 151114.0 173344.0 True False 186399.0766867039 181583.83600799486 234471.0548661178 230963.24654204806 230572.52286314924 176163.25353873582 173375.0297708586 187007.5822790575 181341.02247794007 168339.10831819937 1.1072832602532683 1.0786788514096197 1.3928495713718165 1.372011820957699 1.3696907698198952 1.0464784760873689 1.0299153387645381 1.1108980209492998 1.0772364442798645 1.0 17.361010855040185 -6.777666707482839 24.97785198756271 1.0583998225278128 1.266949055813623 0.5125713053278331 0.10288768417739555 231.35237607180434 356106.0454823189 0.04072863909053531 0.03602689984570029 1.6685272064774874e-07 6.777666707482839 0.2085492332858101 VASGPSPGEGIS(ph)PQSAQAPQAPGDNHVVPVLR ddPTM_A459_Selumetinib_30min_R1 5 VASGPSPGEGISPQSAQAPQAPGDNHVVPVLR 32 0 Q14764 Q14764 MVP Major vault protein 1 VASGPS(0.001)PGEGIS(0.851)PQS(0.148)AQAPQAPGDNHVVPVLR;VASGPS(0.001)PGEGIS(0.948)PQS(0.051)AQAPQAPGDNHVVPVLR;VAS(0.001)GPS(0.004)PGEGIS(0.976)PQS(0.019)AQAPQAPGDNHVVPVLR;VAS(0.002)GPS(0.005)PGEGIS(0.931)PQS(0.062)AQAPQAPGDNHVVPVLR;VAS(0.033)GPS(0.37)PGEGIS(0.578)PQS(0.019)AQAPQAPGDNHVVPVLR 151.1 6.2631999999999984e-21 88024800.0 5296.889999999999 6004.86 5632.789999999999 5972.16 6501.39 5327.1 5563.01 5599.030000000001 2921.72 4475.39 True False 5420.297231046235 5301.808199616325 4867.888056700711 4929.2343673275755 5913.340422413635 5273.5142106198045 5143.387676894953 5450.525536187396 4957.94544601421 5049.849900490196 1.0733580874394066 1.0498942154897852 0.9639668807241535 0.9761150260820798 1.1709933045415108 1.0442912788571987 1.018522882510959 1.079344068357023 0.9818005571874394 1.0 12.302024791133116 -4.998593050795938 23.861852150808165 1.0336076617892531 1.0674921934138277 0.05022697103768248 0.05771605083504333 109.71854576444962 1860202.2126344831 0.014765468273350742 0.0553587192387138 1.0032448735049043e-05 4.998593050795938 0.03388453162457461 VASGPSPGEGIS(ph)PQSAQAPQAPGDNHVVPVLR ddPTM_A459_Selumetinib_30min_R2 2 VASGPSPGEGISPQSAQAPQAPGDNHVVPVLR 32 0 Q14764 Q14764 MVP Major vault protein 1 VASGPS(0.005)PGEGIS(0.883)PQS(0.111)AQAPQAPGDNHVVPVLR;VAS(0.001)GPS(0.006)PGEGIS(0.878)PQS(0.115)AQAPQAPGDNHVVPVLR 131.67 5.915799999999999e-19 75516000.0 67642.0 67448.0 86319.0 78323.0 86140.0 57543.0 58730.0 69118.0 50911.0 65200.0 True False 63882.7284323803 72621.04472049768 80765.32951702113 67655.27228528878 75318.32309862929 65469.02592665439 61461.06137128722 69319.12193689919 61094.62257219326 63317.50659005566 1.0089267861728057 1.1469346888638092 1.2755608024796377 1.0685081572039412 1.1895339402145444 1.0339798493729164 0.9706803802179411 1.0947860342274771 0.9648930582144636 1.0 15.950316823574935 -6.861022542422504 6.187388302908812 1.014022500561692 1.1418534014360224 0.41944213173195755 0.07372719098051127 0.2157593748285764 11.41045984378263 0.02598856426528497 0.022956462895782945 1.377137985526537e-07 6.861022542422504 0.12783090087433036 VASGSDLHLTDIDS(ph)DSNR ddPTM_A459_Selumetinib_30min_R2 3 VASGSDLHLTDIDSDSNR 18 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4 Q92614 MYO18A Unconventional myosin-XVIIIa 1 VASGSDLHLT(0.001)DIDS(0.959)DS(0.04)NR;VASGSDLHLTDIDS(0.987)DS(0.013)NR;VASGSDLHLT(0.001)DIDS(0.987)DS(0.013)NR 121.0 0.00062247 18711900.0 110113.3 97032.3 153577.0 196319.0 244657.0 130841.0 131268.0 139818.0 141883.0 167924.0 True False 103993.64360446499 104474.36540198 143696.02302199477 169580.01353083545 213921.0003986693 148863.1600936585 137372.2221026075 140224.84723188417 170263.56454225004 163075.5978010506 0.6377020535674223 0.6406498998669127 0.8811620190857826 1.0398858922946896 1.311790379941757 0.9128475510803827 0.8423836794404963 0.8598763341830948 1.0440775127494466 1.0 17.315181391586144 -5.3816915382827695 3.0207434776500985 0.9971135822609832 0.6324519154554487 0.5704259526938817 0.12409889030537802 0.20745469300011576 3.5621855264542295 0.03789258176354056 0.0940084671900552 4.1524887231410804e-06 5.3816915382827695 -0.3646616668055346 VASGVLS(ph)PPPAAPPPSSSSVPEAGGPPIKK ddPTM_A459_Selumetinib_30min_R1 2 VASGVLSPPPAAPPPSSSSVPEAGGPPIKK 30 1 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 VAS(0.145)GVLS(0.854)PPPAAPPPSSSSVPEAGGPPIKK;VAS(0.105)GVLS(0.895)PPPAAPPPSSSSVPEAGGPPIKK 79.801 1.2408e-05 136966000.0 4246.4 5081.1 4753.4 4816.5 4099.0 4050.9 4246.4 4011.9 2502.0 3460.8 True False 4345.332857943951 4486.202449860697 4107.914388557208 3975.3886919026418 3728.2461737372287 4010.1516239229154 3926.0906292037466 3905.491379512204 4245.71126115013 3905.0273910466963 1.1127534900028542 1.1488273962294087 1.05195533275277 1.0180181324764244 0.9547298393566239 1.026920229322141 1.0053938771864555 1.0001188182358391 1.0872423765540136 1.0 11.931116952565485 -5.449789690787185 3.068259748535389 1.0114219393564998 1.13086454492357 0.6738694251267529 0.03221462919367893 0.14245927610820563 2.5873884815953443 0.00885806928955018 0.02043355958393286 3.5498525095019573e-06 5.449789690787185 0.11944260556707009 VASGVLS(ph)PPPAAPPPSSSSVPEAGGPPIKK ddPTM_A459_Selumetinib_30min_R2 2 VASGVLSPPPAAPPPSSSSVPEAGGPPIKK 30 1 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 VAS(0.155)GVLS(0.845)PPPAAPPPSSSSVPEAGGPPIKK;VAS(0.073)GVLS(0.917)PPPAAPPPS(0.003)S(0.003)S(0.003)S(0.002)VPEAGGPPIKK 76.972 1.9416e-05 61395000.0 172234.0 172668.0 180342.0 222743.0 195059.0 176319.0 168904.0 166966.0 143862.0 189733.0 True False 162661.9237873301 185911.08038487312 168738.99206152317 192405.01914689297 170553.94457041493 200605.34178547835 176758.3706769265 167451.84341729057 172638.41984012994 184254.91530446333 0.8828091425324914 1.0089884445018638 0.9157909941381938 1.0442327621434815 0.9256412198751448 1.0887380749327502 0.9593142760118529 0.908805299118304 0.936954216688666 1.0 17.49134358054569 -4.748087676058608 24.89371029762177 0.9752474511142143 0.8828089052457114 0.20010699515234465 0.05614346566878135 1083.390499662448 2019813.0591179323 0.013739283756882504 0.2591258692125124 1.7861269523106e-05 4.748087676058608 -0.09243854586850286 VASPSQGQVGSS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 4 VASPSQGQVGSSSPK 15 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.001)S(0.573)S(0.426)PK;VASPSQGQVGSS(0.921)S(0.079)PK;VASPSQGQVGS(0.001)S(0.499)S(0.499)PK;VASPSQGQVGSS(0.731)S(0.269)PK 215.23 1.5218e-07 21090600.0 12005.3 12751.0 16418.8 15237.1 11731.900000000001 12479.7 11911.899999999998 11775.8 6863.45 12615.099999999999 True False 12285.000131752658 11258.106992220928 14189.21714201269 12576.226520790973 10670.751716435181 12354.165548660985 11013.375792674284 11463.467530810789 11646.773363445582 14234.370966479766 0.8630518454719466 0.7909100457429709 0.9968278314107868 0.8835112243741909 0.7496468752685679 0.867910888212311 0.7737170696625415 0.8053371348692456 0.8182148259921238 1.0 13.797091119655148 -6.0608906893486925 24.99692498990851 0.8238455761355236 0.8853019125400008 0.0679778268747161 0.07950322979634694 507.8638767886744 208487.63190242078 0.022568181255663476 0.029135451446172172 8.691791716129393e-07 6.0608906893486925 0.06145633640447723 VASPSQGQVGSS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 VASPSQGQVGSSSPK 15 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.005)S(0.973)S(0.022)PK 192.78 1.1707e-20 0.0 8183.1 8035.0 6058.4 6507.3 7402.8 5984.7 10305.0 8072.8 4696.9 4815.1 True False 7728.316061544762 8651.258663402907 5668.609139887174 5620.994514281373 6472.794082128314 6809.0381013024835 10784.20291897012 8096.29051147602 5636.411242351058 4676.075551867744 1.6527354992067815 1.8501109675072236 1.2122578168402318 1.2020752128430012 1.3842364201200543 1.4561437311642194 2.3062507864447643 1.7314285070184878 1.2053721501783117 1.0 12.19108252450265 -7.061777875832593 24.999935314011204 1.6587837409504609 1.4504456341679188 0.0 0.37249529699405215 745.4076059898324 301644.7178992071 0.14576673403384655 0.11291054743400862 8.67405405317008e-08 7.061777875832593 -0.20833810678254205 VASPSQGQVGSS(ph)SPKR ddPTM_A459_Selumetinib_30min_R1 1 VASPSQGQVGSSSPKR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.061)S(0.649)S(0.291)PKR 152.68 0.00029617 3258400.0 2173.4 2040.3 3132.0 3193.4 2924.2 2194.9 2491.9 2426.9 1462.1 2024.8 True False 2224.035991299779 1801.4207274902642 2706.691602844528 2635.732637542178 2659.706626309443 2172.821298809748 2303.9339767598008 2362.5307283177976 2481.076912441089 2284.702803222187 0.973446519242307 0.7884704850668826 1.1847018347538232 1.1536435434074501 1.1641368070098117 0.9510301715152408 1.0084173633045364 1.0340647917032568 1.0859517084418813 1.0 11.15779079471419 -5.258045620424033 24.999912072948263 1.0734689762761758 0.880958503047195 0.4550958733460533 0.08393963730975795 266.3604629069019 1962103.771567449 0.0227910053066298 0.055454593321170816 5.520194494025895e-06 5.258045620424033 -0.19251047322898074 VASPSQGQVGSS(ph)SPKR ddPTM_A459_Selumetinib_30min_R2 1 VASPSQGQVGSSSPKR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.115)S(0.577)S(0.308)PKR 82.36 0.010351 15481000.0 10856.0 10407.0 10534.0 10936.0 11353.0 7592.0 9444.8 8565.4 7207.6 12062.0 True False 10252.666980011241 11205.183436220786 9856.253908552011 9446.497934347753 9926.73464289225 8637.729086685795 9884.00191451615 8590.323895921694 8649.321397170359 11713.738719160301 0.8752685394323191 0.9565847168754358 0.8414268189566172 0.8064460170087289 0.8474437479687824 0.7374015499045543 0.843795661785487 0.7333545763548917 0.738391183595598 1.0 13.515913999429161 -5.467924110437252 4.091850450443276 0.8041955344686419 0.9152952696548099 0.20038799537056862 0.07682826387649166 0.2863596343743612 9.719702313387733 0.01955663567091177 0.041614823330869945 3.4046767856621783e-06 5.467924110437252 0.111099735186168 VASPSQGQVGSSS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 VASPSQGQVGSSSPK 15 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.001)S(0.025)S(0.974)PK;VASPSQGQVGSS(0.108)S(0.892)PK 254.72 1.3475999999999999e-28 19814300.0 71532.0 57093.0 56115.0 54162.0 46732.0 35894.0 68561.0 49900.0 35434.0 44011.0 True False 67556.53780528413 61471.84951707057 52504.62199339242 46785.0421653386 40861.10837061928 40838.07268670967 71749.22235104424 50045.2007386103 42521.79010868176 42740.28807568927 1.5806289767080528 1.438264744687948 1.2284573725944798 1.0946356300286613 0.9560325915037791 0.9554936226538542 1.6787257545850585 1.1709139781646927 0.9948877750514791 1.0 15.383309011552033 -5.190668483337016 2.139144565080384 1.138679861636874 1.575314057338545 0.37351654544462054 0.2008616075982443 0.43480021381391065 3.547909137621698 0.059347097916039725 0.2582843026924851 6.446611768385507e-06 5.190668483337016 0.43663419570167084 VASPSQGQVGSSS(ph)PKR ddPTM_A459_Selumetinib_30min_R1 3 VASPSQGQVGSSSPKR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.024)S(0.079)S(0.897)PKR;VASPSQGQVGS(0.035)S(0.101)S(0.864)PKR;VASPSQGQVGS(0.003)S(0.028)S(0.969)PKR 245.04 6.9113e-22 35439100.0 6574.4 6709.9 8242.099999999999 8099.2 7260.299999999999 7367.2 7008.8 6578.299999999999 3732.91 6411.1 True False 6727.570728444497 5924.301788652122 7122.86809061458 6684.826760813422 6603.607146910075 7293.0926568824 6480.120573182751 6403.822114670142 6334.475629040737 7234.027134402298 0.9299897005432444 0.8189493457217465 0.9846338641364659 0.9240809630120012 0.912853521865548 1.0081649572752096 0.8957832826429069 0.8852361203092515 0.8756499680401205 1.0 12.820583294128571 -5.262963394845906 24.998511218269254 0.9316188156430729 0.8744695275725411 0.18162273843106302 0.05146638182982042 225.77523403404322 3703464.1156121125 0.013252466665552291 0.030133261939981077 5.458038630401282e-06 5.262963394845906 -0.05714928807053177 VASPSQGQVGSSS(ph)PKR ddPTM_A459_Selumetinib_30min_R2 3 VASPSQGQVGSSSPKR 16 1 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VASPSQGQVGS(0.024)S(0.181)S(0.796)PKR;VASPSQGQVGS(0.18)S(0.18)S(0.64)PKR;VASPSQGQVGS(0.042)S(0.226)S(0.732)PKR 151.96 9.5397e-05 96156000.0 35980.0 33404.8 37689.7 40307.1 34638.1 25465.1 35340.6 25894.0 26446.1 26456.3 True False 33980.37563935191 35966.84074663865 35264.785735442616 34817.20344637417 30286.552209457073 28972.686375838028 36984.00792607037 25969.347253017528 31736.058965773213 25692.437877277425 1.3225827693604892 1.3998998817643529 1.3725745257763586 1.3551537465102428 1.17881192723415 1.1276736958255595 1.439490020477165 1.0107778552219446 1.2352295690025121 1.0 14.649056169227224 -7.148509298668904 0.1596427377053877 0.8913918940063781 1.5740598817725295 0.4738713773163131 0.10985341214629615 5.766576690047044 0.5616435768272793 0.7789518731232963 1.315094804191327 7.103799599115666e-08 7.148509298668904 0.6826679877661515 VASS(ph)PVMVSNPATR ddPTM_A459_Selumetinib_30min_R2 1 VASSPVMVSNPATR 14 0 P51610;A6NEM2;P51610-2;P51610-4 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 VAS(0.286)S(0.714)PVMVSNPATR 108.66 0.0048152 18517000.0 48629.0 55659.0 64862.0 65604.0 65282.0 47370.0 59850.0 53345.0 43023.0 69861.0 True False 45926.394857310836 59927.86632810732 60688.84953640594 56668.6220267877 57080.69153151524 53894.78751795387 62633.14359052512 53500.22511825986 51628.802163058484 67843.93140932337 0.6769418266789807 0.8833194816872273 0.8945361549031023 0.8352791598247516 0.841352945588159 0.794393638434512 0.9231944890198069 0.7885779023546925 0.7609936672385035 1.0 16.049932152935177 -11.335124485309885 2.551789313579247 1.0570080312761772 0.828130045573229 0.37576458328185924 0.06840068632579956 27276223.174090266 18223597.169371277 9587922.643443698 0.016700809269465287 4.622485044124486e-12 11.335124485309885 -0.22887798570294815 VATLNS(ph)EEESDPPTYK ddPTM_A459_Selumetinib_30min_R1 1 VATLNSEEESDPPTYK 16 0 Q00341;Q00341-2;A0A024R4E5;C9JHZ8;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JK79;C9JQ82;C9JHS7;C9JT62;C9JHN6;C9JEJ8;C9JBS3;C9JMQ6 Q00341 HDLBP Vigilin 1 VATLNS(0.54)EEES(0.362)DPPT(0.081)Y(0.017)K 89.866 0.024896 0.0 2463.7 2672.8 1333.6 2114.9 4200.4 1759.6 3763.2 2834.3 618.63 1137.0 True False 2521.0994164743097 2359.867333448991 1152.5044449404409 1745.5724165898257 3820.474561640851 1741.9000215889698 3479.3387942302975 2759.1251568960947 1049.7699270524795 1282.945025317873 1.96508764344728 1.839414228107156 0.8983272254046014 1.3605979852155616 2.977894209219338 1.3577355126010815 2.7119936751523923 2.150618383833299 0.8182501247801947 1.0 10.325243636383117 -8.267290340377379 24.555121414366663 0.9091248451911008 1.8976989868791583 0.3131854504827195 0.5913630712847896 512.4239967330097 2150480.862070886 0.5357274612004362 0.1532409979268168 5.403929314206783e-09 8.267290340377379 0.9885741416880575 VATLNS(ph)EEESDPPTYK ddPTM_A459_Selumetinib_30min_R2 3 VATLNSEEESDPPTYK 16 0 Q00341;Q00341-2;A0A024R4E5;C9JHZ8;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JK79;C9JQ82;C9JHS7;C9JT62;C9JHN6;C9JEJ8;C9JBS3;C9JMQ6 Q00341 HDLBP Vigilin 1 VATLNS(0.868)EEES(0.132)DPPTYK;VATLNS(0.567)EEES(0.433)DPPTYK;VATLNS(0.988)EEES(0.012)DPPTYK 211.06 7.5621e-21 44870000.0 177709.0 159538.0 177281.0 193525.0 189679.0 141129.0 150109.0 166151.0 131218.0 161871.0 True False 167832.64520549148 171774.05160447696 165874.9334689586 167166.56115075407 165849.82826822507 160568.23870849286 157089.36593534064 166634.47190222103 157465.26653725244 157197.36363863305 1.0676555975283843 1.0927285778109674 1.0552017516672458 1.0634183505458674 1.0550420466941317 1.0214435852601753 0.9993129801875006 1.0600335021220975 1.0017042454938063 1.0 17.26221749675748 -6.605324803719891 2.1060719286348304 1.0184726498782322 1.0709959809102407 0.6471219342247293 0.01877681110593963 0.21210268886834416 1.9159198711573635 0.006980065360386446 0.0071283048147545705 2.481276693618952e-07 6.605324803719891 0.05252333103200857 VATLNS(ph)EEESDPPTYKDAFPPLPEK ddPTM_A459_Selumetinib_30min_R1 2 VATLNSEEESDPPTYKDAFPPLPEK 25 1 Q00341;Q00341-2;A0A024R4E5;C9JHZ8;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JK79;C9JQ82;C9JHS7;C9JT62;C9JHN6;C9JEJ8;C9JBS3 Q00341 HDLBP Vigilin 1 VAT(0.074)LNS(0.729)EEES(0.06)DPPT(0.085)Y(0.052)KDAFPPLPEK;VAT(0.105)LNS(0.793)EEES(0.055)DPPT(0.022)Y(0.025)KDAFPPLPEK 71.15899999999998 0.00053844 47042000.0 3571.7 2539.6400000000003 10561.400000000001 10122.1 6405.1 4817.5 3458.2 3686.8500000000004 2805.79 1940.5900000000001 True False 3654.9136606816155 2242.2977681533966 9127.21988961756 8354.465250349365 5825.759835912253 4769.040323940024 3197.3451897872064 3589.0627614234086 4761.220703206399 2189.683629447328 1.6691514753682062 1.0240281920175602 4.168282470980182 3.815375489863811 2.660548655324543 2.177958614571056 1.4601859130646242 1.6390782271726083 2.174387495607355 1.0 11.09650672563073 -6.981130593718907 3.091018151620686 1.6276228791316318 2.7204127062515293 0.24837786182715238 0.8950736159869528 0.4278776941698062 8.418562422343749 0.390916441353184 0.32101822474008573 1.0444061157879124e-07 6.981130593718907 1.0927898271198975 VATLNSEEES(ph)DPPTYK ddPTM_A459_Selumetinib_30min_R1 2 VATLNSEEESDPPTYK 16 0 Q00341;Q00341-2;A0A024R4E5;C9JHZ8;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JK79;C9JQ82;C9JHS7;C9JT62;C9JHN6;C9JEJ8;C9JBS3;C9JMQ6 Q00341 HDLBP Vigilin 1 VATLNSEEES(1)DPPTYK;VAT(0.002)LNS(0.278)EEES(0.72)DPPTYK 192.23 1.1005e-06 188383000.0 7650.0 8397.7 6638.9 7795.5 7833.2 6626.6 8013.4 7536.0 3724.4 5980.3 True False 7828.230115691226 7414.493380015189 5737.373844867348 6434.16226465837 7124.688443063786 6559.942420471397 7408.942786374646 7336.120799622124 6320.034780586549 6747.929758054948 1.1600935985361633 1.0987804624321362 0.8502420817316144 0.9535016657483673 1.0558332256732672 0.9721414797836103 1.0979578999811983 1.0871661476418093 0.936588703082212 1.0 12.720229240766342 -7.222686559719877 24.991632632414255 1.0376921979301057 1.0104606948220562 0.002777949598969154 0.08964039367151225 3238.8007682470134 2088696.3794616112 0.03640367811897638 0.028197658690995293 5.988436383110107e-08 7.222686559719877 -0.02723150310804945 VATLNSEEES(ph)DPPTYK ddPTM_A459_Selumetinib_30min_R2 3 VATLNSEEESDPPTYK 16 0 Q00341;Q00341-2;A0A024R4E5;C9JHZ8;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JK79;C9JQ82;C9JHS7;C9JT62;C9JHN6;C9JEJ8;C9JBS3;C9JMQ6 Q00341 HDLBP Vigilin 1 VATLNSEEES(1)DPPTYK;VATLNS(0.003)EEES(0.97)DPPT(0.025)Y(0.003)K;VATLNS(0.205)EEES(0.795)DPPTYK 210.57 4.4924e-08 32847100.0 170098.0 153246.0 179081.0 174629.0 186259.0 142268.0 148788.0 152726.0 125815.0 172373.0 True False 160644.63411624456 164999.4754364457 167559.12342865008 150844.22894817224 162859.47924341323 161864.12561968024 155706.9368178288 153170.40737484957 150981.51556481863 167396.1436111603 0.959667472922204 0.9856826559859003 1.0009736175157558 0.9011212904555553 0.972898632729048 0.9669525362284914 0.9301703937667523 0.9150175390577976 0.9019414205594202 1.0 17.352906766619334 -5.743955824759873 24.98303510332898 0.9395560144176001 0.982465389707004 0.2600004799837934 0.031576484469983145 326.2719075316548 466220.931348796 0.008615662855956056 0.014879376011030452 1.8032011481924659e-06 5.743955824759873 0.04290937528940397 VATTPGS(ph)PSLGR ddPTM_A459_Selumetinib_30min_R1 1 VATTPGSPSLGR 12 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 VAT(0.019)T(0.063)PGS(0.459)PS(0.459)LGR 104.94 0.0095334 13488000.0 2451.7 2914.3 2707.0 2782.1 3049.7 2107.0 2908.9 2859.6 1385.9 2567.6 True False 2508.8198398222457 2573.092401178686 2339.404268486633 2296.2584614849666 2773.8551734682646 2085.8054930029325 2689.4793310311757 2783.7541187101133 2351.7710778688906 2897.176470541925 0.8659534085450321 0.8881379603008379 0.8074773118839533 0.7925849477354913 0.9574339712034895 0.7199442333634501 0.9283104976094538 0.9608507272563221 0.8117458849267077 1.0 11.500431848256165 -10.016132907269759 0.3319272256936695 1.047701227922194 0.8424142022531369 0.24831997592072608 0.07369519848396126 12.216657442447254 1.4141204978566082 0.7309145482348411 0.06881635854104692 9.635341078694363e-11 10.016132907269759 -0.2052870256690571 VATTPGS(ph)PSLGR ddPTM_A459_Selumetinib_30min_R2 1 VATTPGSPSLGR 12 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;A0A087WWW7;H0Y4U1 E9PGF5 TNS1 Tensin-1 1 VATT(0.051)PGS(0.726)PS(0.223)LGR 147.52 0.00062738 55159000.0 178810.0 133230.0 174250.0 173570.0 178160.0 89577.0 122560.0 120350.0 75765.0 120500.0 True False 168872.4560331438 143448.31259802973 163038.94470905492 149929.46657504953 155777.94802939158 101915.41865095522 128259.28284803269 120700.19857498481 90920.11705097563 117020.85190340049 1.4430971342829249 1.225835483717422 1.3932469475067735 1.2812200914313525 1.3311982052393934 0.870916738284262 1.0960378493391025 1.031441803847246 0.7769565472487695 1.0 16.836406100461183 -6.7523578281678756 24.9996579402529 0.9658461526042811 1.3291165273985683 0.787419790738954 0.09857978598314433 88.94932967889079 244859.0164522194 0.03184960076730971 0.03141406932126996 1.7686511134515965e-07 6.7523578281678756 0.36327037479428725 VAVAT(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 VAVATPAK 8 0 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 VAVAT(1)PAK;VAVAT(1)PAK 99.788 0.042955 79813000.0 21337.6 27903.0 24760.0 26063.0 20283.4 21195.1 22339.8 19215.5 11247.4 16642.8 True False 21834.724564257915 24636.10378824724 21397.727996944606 21511.586313102573 18448.77005132512 20981.896537611043 20654.690900123824 18705.842519259404 19086.016322406052 18779.065494600065 1.1627162475436548 1.3118918934135126 1.1394458368068177 1.1455088816473986 0.982411507997034 1.1173024847080066 1.0998785272921645 0.9961008190017914 1.0163453728778065 1.0 14.19683765128176 -5.804398407747806 1.7422302255634146 1.0426572610619949 1.2339644753467085 0.6337364625460038 0.058768804802986484 0.22611227605193726 1.3998644145766903 0.018423449638902703 0.03696630492934549 1.5689228647331933e-06 5.804398407747806 0.19130721428471364 VAVAT(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 VAVATPAK 8 0 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 VAVAT(1)PAK 106.18 0.032362 3285900.0 55485.0 59495.0 50855.0 62346.0 52463.0 50762.0 55517.0 48950.0 54199.0 58071.0 True False 52401.36582405336 64058.07519342325 47583.04466673743 53854.367247151094 45872.12891482924 57754.00472844362 58098.65050484853 49092.43639589128 65040.314446589204 56394.33934342214 0.9291954907911423 1.135895480632047 0.8437556893250054 0.9549605133096162 0.8134172586983197 1.0241099621141332 1.030221316204233 0.8705206403241151 1.1533128183400827 1.0 15.783262737013482 VAVEEVDEEGKFVR ddPTM_A459_Selumetinib_30min_R1 2 VAVEEVDEEGKFVR 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 199.96 0.00021349 24886000.0 3269.6 3813.8999999999996 4866.8 4479.5 3970.6 3763.5 3530.9100000000003 3591.21 2151.37 3092.21 False True 3345.775318465888 3367.366814965991 4205.915291418822 3697.239415629168 3611.459931066365 3725.6426069845934 3264.5706159480524 3495.9594449059136 3650.7177601520975 3489.1252741760572 0.9589152167246214 0.965103442942782 1.20543544897855 1.0596465088236926 1.035061698069639 1.067786999383216 0.9356415603962421 1.0019587060345576 1.0463131797450866 1.0 11.768649681904316 -7.22322289031082 24.968081712147665 0.9961415256106635 1.0518679617586395 0.12409613743931158 0.06824500916584657 1211.1774498695372 791303.2245842876 0.027564979246154114 0.021351361016221374 5.98104554720429e-08 7.22322289031082 0.05572643614797601 VAVEEVDEEGKFVR ddPTM_A459_Selumetinib_30min_R2 2 VAVEEVDEEGKFVR 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 ; 166.7 0.0006425 17410600.0 84472.0 80944.0 77730.0 81616.0 70787.0 53455.0 56356.0 54579.0 39148.0 72426.0 False True 79777.38440820832 87152.14452401799 72728.93642602503 70499.76000454696 61894.10421619083 60817.9410338236 58976.66566729546 54737.81585396017 46978.69388651223 70334.87319465278 1.1342507746821873 1.2391028883044 1.034038068494794 1.0023443109001966 0.879991694090327 0.8646911307497358 0.8385124332857853 0.7782457459256729 0.6679288914973659 1.0 16.101952558325422 -5.902143341458825 0.9116261894466001 0.804944394313065 1.210627021008633 0.7270394874132563 0.08474945769485973 0.32701692285675416 0.531729093334108 0.03594586693551118 0.09321251193964178 1.252727636544349e-06 5.902143341458825 0.405682626695568 VAVEYLDPS(ph)PEVQK ddPTM_A459_Selumetinib_30min_R1 1 VAVEYLDPSPEVQK 14 0 J3QT28;O43684-2;O43684 J3QT28 BUB3 Mitotic checkpoint protein BUB3 1 VAVEYLDPS(1)PEVQK 111.66 0.0038605 3875500.0 1148.4 721.93 1157.7 1442.5 1038.5 925.78 893.41 1009.1 710.01 682.31 True False 1175.155485602589 637.4060999838482 1000.4906987909029 1190.5944540785968 944.5678583620662 916.467493740985 826.0193644114828 982.335389981248 1204.8351129213431 769.8911347622142 1.5263917618242782 0.8279171836167657 1.299522300772967 1.5464452054592361 1.2268849655656862 1.1903858251648032 1.072904112172436 1.2759406435880687 1.5649421827586887 1.0 9.588510647994577 -11.67331427009485 2.6662599997701295 0.3308747948381336 1.2657059634151464 0.12720210974988522 0.21761755001096245 3533547.075677885 7680920.961789912 14328827.457253024 0.05406723536786555 2.121708566670754e-12 11.67331427009485 0.9348311685770128 VAVNALAVGEPGT(ph)ASKPASPIGGPTQEEK ddPTM_A459_Selumetinib_30min_R2 1 VAVNALAVGEPGTASKPASPIGGPTQEEK 29 1 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4 Q96L91-3 EP400 E1A-binding protein p400 1 VAVNALAVGEPGT(0.626)AS(0.233)KPAS(0.137)PIGGPT(0.004)QEEK 59.555 0.0055474 10247000.0 43649.0 35668.0 37785.0 43915.0 45538.0 29588.0 39455.0 35033.0 29589.0 41354.0 True False 41223.163320791326 38403.620909303674 35353.95423719741 37933.70124239954 39817.109325114725 33663.47842687819 41289.735678599296 35134.94022997465 35507.62678573644 40160.00256940431 1.026473124585828 0.9562653997079491 0.8803274894243069 0.9445642135316779 0.9914618221526008 0.8382339709441288 1.0281308027120415 0.8748739537367964 0.8841539968622348 1.0 15.293471741140593 -4.831614604093518 3.658846035121685 0.9281360411577404 1.0322031957655098 0.19350807582249008 0.05888607369715251 0.37798101893309716 8.544298489041301 0.014095160947778174 0.09771912922784297 1.4736196225488421e-05 4.831614604093518 0.10406715460776939 VAVNALAVGEPGTASKPAS(ph)PIGGPTQEEK ddPTM_A459_Selumetinib_30min_R2 1 VAVNALAVGEPGTASKPASPIGGPTQEEK 29 1 Q96L91-3;Q96L91-5;Q96L91-2;Q96L91;Q96L91-4 Q96L91-3 EP400 E1A-binding protein p400 1 VAVNALAVGEPGT(0.037)AS(0.037)KPAS(0.891)PIGGPT(0.034)QEEK 86.641 2.1279e-06 10080000.0 41963.0 41791.0 35520.0 39514.0 39973.0 33975.0 35348.0 33903.0 21625.0 36062.0 True False 39630.86445119854 44996.23532075555 33234.68187125189 34132.12503454801 34951.23437684593 38654.74785565723 36991.752040733205 34001.65211705619 25950.604252984238 35020.79635967159 1.1316380142867253 1.2848432930717484 0.9489984616547293 0.9746244683873911 0.9980136950024996 1.1037655300200522 1.0562795791626052 0.9708988844186021 0.7410055438621553 1.0 15.095924270033828 -1.5228787554429695 0.30512357946226304 0.9348896012563154 3.384157550375808 0.34145851166853625 0.10862061545672051 64.64489705024296 0.9223850214888759 0.11310508130505732 86.92295028044256 0.029999999297990267 1.5228787554429695 2.4492679491194926 VAVPTGPTPLDS(ph)TPPGGAPHPLTGQEEAR ddPTM_A459_Selumetinib_30min_R1 1 VAVPTGPTPLDSTPPGGAPHPLTGQEEAR 29 0 O94966-2;O94966-7;O94966-6;O94966-5;A0A0A0MR08;E7ESU0;O94966-4;O94966-3;O94966 O94966-2 USP19 Ubiquitin carboxyl-terminal hydrolase 19;Ubiquitin carboxyl-terminal hydrolase 1 VAVPT(0.098)GPT(0.085)PLDS(0.436)T(0.382)PPGGAPHPLTGQEEAR 61.526 0.0016939 4110900.0 981.09 1338.7 1284.7 1133.6 1124.3 1074.0 1205.0 1115.1 682.41 968.07 True False 1003.947488131177 1181.9643816552548 1110.244796351969 935.63804030745 1022.6072635112868 1063.1965351139775 1114.1058798489348 1085.5239256447217 1157.9999287455867 1092.331214300328 0.9190870635096119 1.0820567664655996 1.0163994050679173 0.8565515917319594 0.9361695886044037 0.9733279807397868 1.019934123701257 0.99376810937334 1.060117951025799 1.0 10.093194658114212 -7.216555855173236 4.581872775525256 1.0182019874777886 0.9650039167913399 0.1752436432767982 0.058100713327632315 0.4502705665625146 21.644303753778356 0.02519350733544206 0.018758064476298474 6.073571448548211e-08 7.216555855173236 -0.05319807068644866 VAVPTGPTPLDS(ph)TPPGGAPHPLTGQEEAR ddPTM_A459_Selumetinib_30min_R2 2 VAVPTGPTPLDSTPPGGAPHPLTGQEEAR 29 0 O94966-2;O94966-7;O94966-6;O94966-5;A0A0A0MR08;E7ESU0;O94966-4;O94966-3;O94966 O94966-2 USP19 Ubiquitin carboxyl-terminal hydrolase 19;Ubiquitin carboxyl-terminal hydrolase 1 VAVPT(0.029)GPT(0.078)PLDS(0.481)T(0.412)PPGGAPHPLTGQEEAR;VAVPT(0.001)GPT(0.003)PLDS(0.964)T(0.032)PPGGAPHPLTGQEEAR 97.388 9.6104e-08 12781900.0 54486.0 50419.0 55771.0 53614.0 59936.0 49714.0 49793.0 51618.0 36937.0 44782.0 True False 51457.88624473954 54285.97517736297 52182.754578873544 46311.680710691304 52406.303845361566 56561.65224124045 52108.47316295767 51768.19983418007 44325.432106010536 43489.02730239068 1.1832383807285292 1.2482683229472635 1.199906224989423 1.0649049561093646 1.2050465852217551 1.300595937636231 1.1981981753841886 1.1903738263498542 1.0192325479667346 1.0 15.408363820664361 -8.271936975308455 4.211590265048976 1.0013093526798338 1.2005641195906598 0.6496233962818244 0.05570113922102138 0.1350872709704064 5.728972025698032 0.052612779067406884 0.015334761691873946 5.3464194085374966e-09 8.271936975308455 0.199254766910826 VAVVAGYGDVGK ddPTM_A459_Selumetinib_30min_R2 1 VAVVAGYGDVGK 12 0 P23526-2;P23526 P23526-2 AHCY Adenosylhomocysteinase 0 127.76 0.035272000000000005 2460800.0 18840.0 23150.0 22175.0 21551.0 23262.0 19686.0 14652.0 17494.0 12819.0 14089.0 False True 17792.948222495554 24925.53056101771 20748.284642314484 18615.71662245139 20339.61959508145 22397.56780828458 15333.347032387206 17544.904643712394 15383.158192786352 13682.213962381808 1.300443646870009 1.8217468773364116 1.5164420538489087 1.3605778036824938 1.486573711754813 1.636984180328196 1.120677331500959 1.28231474028624 1.124317909008086 1.0 13.74001407571723 -7.67789632506035 0.8240057937339251 1.0251740406772933 1.541293080168264 0.5647108629335595 0.15919042182990434 0.4567959438084191 0.575138583537769 0.14108319491799587 0.06512942356805246 2.0994410031416556e-08 7.67789632506035 0.5161190394909707 VCAKPWAPDMTLPGIS(ph)PPPEK ddPTM_A459_Selumetinib_30min_R2 1 VCAKPWAPDMTLPGISPPPEK 21 1 Q96FF9;B5MBX0 Q96FF9 CDCA5 Sororin 1 VCAKPWAPDMTLPGIS(1)PPPEK 68.303 0.0043122 8842700.0 55350.0 61173.0 57255.0 63898.0 66198.0 53744.0 53022.0 52992.0 43672.0 64472.0 True False 52273.868583605574 65864.7723978029 53571.275634530575 55194.98216980182 57881.615422371375 61146.74816054278 55487.62806109981 53146.19794670211 52407.620297633606 62610.52584162678 0.8349054393159424 1.0519760297878302 0.8556273073003575 0.8815607508139675 0.9244709997929553 0.9766209010161226 0.8862348193889262 0.8488380704729317 0.8370416889677399 1.0 15.934117597457725 -7.492985111018263 24.170588820214146 0.879271195256143 0.9229989671126003 0.021622549270639557 0.0712839728889131 1235.7025232178394 999134.472527315 0.02878275917851654 0.019368759421662017 3.213770714926833e-08 7.492985111018263 0.043727771856457376 VDATEESDLAQQYGVR ddPTM_A459_Selumetinib_30min_R1 1 VDATEESDLAQQYGVR 16 0 P07237;H7BZ94;I3NI03;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 178.22 1.5562e-05 3484800.0 681.67 874.63 654.6 864.98 813.35 665.77 760.65 520.77 414.41 556.37 False True 697.5515847010766 772.2279129955442 565.7089154604174 713.9274806855489 739.7826361086055 659.0729582707938 703.2735580971718 506.95748790063857 703.2235026911368 627.7855090027306 1.1111304334010084 1.2300824117814821 0.9011181483928723 1.1372156101845345 1.1784003063144737 1.0498378009995244 1.120244969041031 0.8075329561301383 1.1201652357478644 1.0 9.294127917753082 -7.650957968328104 20.1964253744649 0.9709511472644099 1.103124785906988 0.22740649644690458 0.1080630363271183 3.3943832091232986 601.1868265019982 0.048796037199402745 0.028172221315687265 2.2337884017640574e-08 7.650957968328104 0.13217363864257803 VDCTAHSDVCSAQGVR ddPTM_A459_Selumetinib_30min_R1 1 VDCTAHSDVCSAQGVR 16 0 Q8NBS9-2;Q8NBS9 Q8NBS9-2 TXNDC5 Thioredoxin domain-containing protein 5 0 130.66 0.0010792 3197400.0 1684.8 1859.6 1730.0 1879.4 2296.3 1998.0 1876.1 1400.5 782.49 1362.6 False True 1724.0525619498803 1641.8771674954146 1495.0755022097808 1551.1980707073235 2088.600070444693 1977.9019340388506 1734.5842665432244 1363.354190534869 1327.8283791915921 1537.5029828479614 1.1213328241850742 1.067885516848961 0.9724049441780002 1.0089073569366314 1.3584364347546944 1.2864377865304206 1.1281827000622813 0.8867327125502472 0.8636265386178419 1.0 10.58637349403155 -7.757141065900045 23.952177508296984 0.906384665865358 1.1355706157780228 0.4317889263111393 0.11441746176620902 64.71475807524902 360631.24874481634 0.06367175442077852 0.03505097817391151 1.7492784023044855e-08 7.757141065900045 0.22918594991266472 VDCTANTNTCNK ddPTM_A459_Selumetinib_30min_R1 1 VDCTANTNTCNK 12 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 196.24 0.0022278000000000003 1102300.0 0.0 265.19 339.74 213.04 292.02 263.13 273.72 225.37 199.51 386.97 False True 0.0 234.1414315165137 293.6051740582374 175.83656325608607 265.60684256031846 260.4831511029245 253.07308002676373 219.3924554950686 338.5538983661317 436.6413689069986 0.0 0.5362328175697528 0.6724172168871456 0.4027024825802476 0.6082951856467149 0.5965608612737872 0.5795902496830676 0.5024545797029085 0.7753591905723464 1.0 8.77030501247542 -8.76761262558957 0.11040509602795905 1.4561188376546013 1.5652131668917763e-12 0.5805276449387251 0.1584266594483567 12.61774073911267 0.77676714079297 5.6812669714583865 3.825106709692563 1.7076048294681533e-09 8.76761262558957 -1.456118837653036 VDCTANTNTCNK ddPTM_A459_Selumetinib_30min_R2 1 VDCTANTNTCNK 12 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 140.78 0.014494 1716500.0 3732.7 2965.7 4086.2 5407.0 4570.2 3354.1 3067.7 3667.2 2824.4 3804.5 False True 3525.2514771820142 3193.159653771499 3823.2983407181705 4670.5572724047415 3996.050617893614 3816.096829511698 3210.3541285322276 3677.870944862357 3389.35892032965 3694.654199721884 0.9541492347098081 0.8642648218639419 1.0348189936167693 1.264139218429784 1.081576353801776 1.0328698230537936 0.8689187011801774 0.9954574220069661 0.9173683752554663 1.0 11.851223626654047 -7.107743136207325 8.646372818777936 0.9452471637929195 1.04369263794344 0.16880745241352246 0.10121727524687646 0.668053754059777 48.902537527456396 0.043419461103360445 0.033632473486648114 7.802914780437897e-08 7.107743136207325 0.0984454741505204 VDDDS(ph)LGEFPVTNSR ddPTM_A459_Selumetinib_30min_R1 3 VDDDSLGEFPVTNSR 15 0 J3KMZ8;Q92785-2;Q92785 J3KMZ8 DPF2 Zinc finger protein ubi-d4 1 VDDDS(1)LGEFPVTNSR;VDDDS(1)LGEFPVTNSR;VDDDS(1)LGEFPVTNSR 201.75 1.4827e-05 31648400.0 6804.799999999999 6906.8 7838.6 8476.1 7144.08 7022.35 7476.8 6471.87 3624.9700000000003 5184.679999999999 True False 6963.338600164136 6098.1486451157925 6774.161174347734 6995.908251102658 6497.8992253897695 6951.711534783649 6912.818956393786 6300.214984003503 6151.309332666418 5850.184181059863 1.1902768160202788 1.042385753402213 1.1579398126095368 1.1958441024390496 1.1107170345895951 1.1882893460499948 1.1816412513599543 1.0769259204523214 1.0514727643244903 1.0 12.514266330369901 -8.121029474227518 2.136278780162929 1.0147045118005609 1.1494400285013018 0.5560345249579113 0.04599603043756994 0.2523658414796169 2.052697690480734 0.04102040062582731 0.012736731131656392 7.567815328486892e-09 8.121029474227518 0.1347355167007409 VDDDS(ph)LGEFPVTNSR ddPTM_A459_Selumetinib_30min_R2 4 VDDDSLGEFPVTNSR 15 0 J3KMZ8;Q92785-2;Q92785 J3KMZ8 DPF2 Zinc finger protein ubi-d4 1 VDDDS(1)LGEFPVTNSR;VDDDS(0.998)LGEFPVT(0.002)NSR;VDDDS(1)LGEFPVTNSR;VDDDS(0.995)LGEFPVT(0.005)NSR 189.04 1.9661e-14 23894700.0 54934.0 55521.5 64650.0 68682.0 63420.0 52525.1 48565.3 51488.4 44771.6 57985.0 True False 51880.98819822559 59779.820520239526 60490.48938559778 59327.393116941465 55452.612618006424 59759.95574961534 50823.68268031631 51638.2227196365 53727.1710230247 56310.82238687692 0.9213324543865357 1.061604465825934 1.0742249326426978 1.0535699995524759 0.9847594168848349 1.0612516957937774 0.9025562143478947 0.9170212852666603 0.9541180317683597 1.0 15.78112460031695 -7.260693484873892 24.998380238175255 0.9365089887423387 1.029290351229038 0.40057754466089435 0.04917927513434023 62.15947580563621 2083309.2950870912 0.019418820514629394 0.014147371192484525 5.4866406286650905e-08 7.260693484873892 0.09278136248669921 VDDDSLGEFPVT(ph)NSR ddPTM_A459_Selumetinib_30min_R2 2 VDDDSLGEFPVTNSR 15 0 J3KMZ8;Q92785-2;Q92785 J3KMZ8 DPF2 Zinc finger protein ubi-d4 1 VDDDS(0.391)LGEFPVT(0.603)NS(0.006)R;VDDDS(0.118)LGEFPVT(0.818)NS(0.064)R 132.15 0.0015358 0.0 8032.700000000001 8723.2 10823.0 9277.5 12725.5 8266.0 7818.5 9944.6 8291.0 10686.7 True False 7586.274691445862 9392.24139049113 10126.659963191414 8013.8884954198265 11126.808922586575 9404.566468722964 8182.075742063838 9973.537139582839 9949.43166989559 10378.147203618837 0.7309854584448894 0.9050017509113839 0.9757676167534288 0.7721887479708711 1.0721382829014683 0.9061893500068694 0.7883946509460539 0.9610132660389601 0.9586905518574881 1.0 13.341261283867402 -4.766549734201477 4.787524121450511 0.9226697210100671 0.7180675842870149 0.31604608820070945 0.0865268994542301 0.22293766984087482 12.476462375098585 0.021052810586035035 0.1542411473112539 1.711789136126252e-05 4.766549734201477 -0.20460213672305216 VDDFLANEAK ddPTM_A459_Selumetinib_30min_R2 1 VDDFLANEAK 10 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 133.81 0.030587 6986500.0 56716.0 54130.0 61484.0 53806.0 71199.0 48407.0 58766.0 51946.0 34609.0 54568.0 False True 53563.95177213682 58281.59694461719 57528.18637871762 46477.529979472856 62254.34509286398 55074.62485500513 61498.73544261988 52097.154259876785 41531.767056255776 52992.48005530914 1.0107840153212535 1.0998088197379647 1.0855915088079382 0.877058970083368 1.17477696888102 1.0392913258168484 1.160518159905568 0.9831046632560339 0.7837294463838713 1.0 15.69350002683577 -8.002878158466432 24.64159262016337 0.8890488090176395 1.0629871441741683 0.359052335854961 0.09226826992376343 89.25140436939714 764125.5830030068 0.04949436274864991 0.023058305540023465 9.933947067108186e-09 8.002878158466432 0.1739383351565288 VDDKPS(ph)SPGDSSK ddPTM_A459_Selumetinib_30min_R1 3 VDDKPSSPGDSSK 13 1 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 VDDKPS(0.734)S(0.266)PGDSSK;VDDKPS(0.39)S(0.39)PGDS(0.193)S(0.027)K;VDDKPS(0.869)S(0.128)PGDS(0.001)S(0.001)K 173.33 0.00072312 351411000.0 14383.8 18675.1 20462.4 22104.3 14375.699999999999 16934.4 17234.7 16244.1 9748.470000000001 14302.699999999999 True False 14718.914553997321 16488.61061018155 17683.718471917582 18244.19895410017 13075.420473235976 16764.055311204967 15934.672703263434 15813.253699726858 16542.441589921742 16138.590865095812 0.9120322013882306 1.0216883709371896 1.0957411721839692 1.1304703803823617 0.8101959199867448 1.0387558276517126 0.9873645621518662 0.9798410426233317 1.0250239149255198 1.0 13.978226995297184 VDDKPS(ph)SPGDSSK ddPTM_A459_Selumetinib_30min_R2 5 VDDKPSSPGDSSK 13 1 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 VDDKPS(0.824)S(0.175)PGDS(0.001)SK;VDDKPS(0.777)S(0.201)PGDS(0.011)S(0.011)K;VDDKPS(0.479)S(0.479)PGDS(0.026)S(0.015)K;VDDKPS(0.585)S(0.382)PGDS(0.028)S(0.005)K;VDDKPS(0.475)S(0.475)PGDS(0.028)S(0.021)K 91.592 0.010769 661236100.0 797555.0 732484.0 711227.0 646145.0 582208.0 475739.0 622994.0 588887.0 394827.0 603245.0 True False 753230.0859656279 788663.1674927226 665467.4291454061 558138.9363377045 509065.8260344415 541267.7289213402 651964.4554391919 590600.5636745094 473803.4323881158 585827.7494312583 1.285753511500419 1.3462372997154606 1.1359438500335035 0.9527355726654549 0.8689684408576754 0.9239366510835676 1.1128944575809891 1.0081471289946315 0.8087760145334536 1.0 19.160117006709548 -5.529478544453378 2.8181965427359983 0.9556250710661134 1.314959976025605 0.7721465580258304 0.0791468403234669 0.12672726117663405 2.0223973159868933 0.02363396773852883 0.05154449666655171 2.9547548592833168e-06 5.529478544453378 0.3593349049594916 VDDKPSS(ph)PGDSSK ddPTM_A459_Selumetinib_30min_R1 2 VDDKPSSPGDSSK 13 1 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 VDDKPS(0.07)S(0.928)PGDS(0.002)SK;VDDKPS(0.053)S(0.539)PGDS(0.354)S(0.053)K 140.49 0.0041734 10454000.0 3832.9 4826.1 5930.1 5568.4 4098.1 4885.5 4201.0 4350.799999999999 2424.16 3713.4 True False 3922.1991124748893 4261.05796840698 5124.824991707639 4595.983471813694 3727.42757857832 4836.356305679087 3884.115187755497 4235.402650609861 4113.622466358788 4190.051061579057 0.9360742995329452 1.0169465492864813 1.2230936846331186 1.0968800628605366 0.8895900130566922 1.154247581855593 0.9269851681214917 1.0108236363624916 0.9817595074386836 1.0 12.032752109932304 -7.0232391290774645 1.1180796061199254 0.9859774505568607 1.058782114292928 0.0679488871795908 0.09640048847697857 1.4157884044516382 3.6209637022634045 0.060745561307307516 0.04267813427983595 9.478963935651032e-08 7.0232391290774645 0.0728046637360672 VDDKPSS(ph)PGDSSK ddPTM_A459_Selumetinib_30min_R2 1 VDDKPSSPGDSSK 13 1 Q9HC52;C9JM54;C9J6K3 Q9HC52 CBX8 Chromobox protein homolog 8 1 VDDKPS(0.168)S(0.832)PGDSSK 104.16 0.037508 51680000.0 15966.0 13426.0 14014.0 13687.0 12673.0 9739.1 13910.0 12663.0 7671.6 13412.0 True False 15078.67363696199 14455.731028605776 13112.354497289527 11822.806988608043 11080.904441942526 11080.572622252583 14556.842562142092 12699.847233527506 9206.134362413586 13024.760711439048 1.1576929489168337 1.1098653824718616 1.0067251742885033 0.9077177884907026 0.8507568536142608 0.8507313775462321 1.1176284067435869 0.9750541691237224 0.706817926745346 1.0 13.668969247362917 -5.372985181485791 2.1328982609506193 0.9176570946957624 1.1496538899120834 0.4214412096461214 0.10216779245793194 0.34517791774697937 2.9585732034379526 0.030085434515919315 0.09309050420480647 4.236574213711633e-06 5.372985181485791 0.231996795216321 VDDLSS(ph)SPTSSPER ddPTM_A459_Selumetinib_30min_R1 1 VDDLSSSPTSSPER 14 0 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 VDDLS(0.063)S(0.462)S(0.462)PT(0.013)SSPER 116.9 0.0025831 4247900.0 1707.8 1998.8 2121.7 2186.2 1824.5 1565.2 1740.1 1887.5 1146.9 1732.0 True False 1747.5884171996702 1764.77956678309 1833.584793663867 1804.4212100565876 1659.4742971416385 1549.4555090878941 1608.842856037453 1837.4373685359278 1946.2055337382433 1954.319071108667 0.8942185761960966 0.9030150669214659 0.9382218189293375 0.9232991872882642 0.849131711230876 0.7928365086305496 0.8232242522838256 0.9401931320731403 0.9958484070025367 1.0 10.932450312217593 -7.997062194131116 4.661107838362928 0.9912911006562862 0.8760024273627064 0.5806934652334677 0.04219197646871918 0.16276445181055743 9.341168981720058 0.03199935164017516 0.013177759782911667 1.006787479231936e-08 7.997062194131116 -0.11528867329357984 VDDLSSSPT(ph)SSPER ddPTM_A459_Selumetinib_30min_R1 1 VDDLSSSPTSSPER 14 0 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 VDDLS(0.021)S(0.181)S(0.181)PT(0.613)S(0.002)SPER 150.9 0.00025476 0.0 1307.6 1988.3 1692.0 1778.4 1447.9 1099.4 1641.9 1250.6 759.53 1049.0 True False 1338.064535853313 1755.5089116644078 1462.2356934907216 1467.835824702514 1316.9377006475067 1088.3410341753329 1518.0501610987264 1217.4300254786913 1288.8669361236439 1183.6493681252846 1.13045684971099 1.4831325550782486 1.235362205115417 1.2400934467842755 1.1126079530911506 0.9194792507675603 1.2825167671935485 1.028539412315076 1.0888925139756611 1.0 10.209026060068137 -6.147148725926076 2.3213775807469332 1.0739862075068138 1.301092939002722 0.40864276014303946 0.11908388413595279 0.2948941959214917 3.115096582170704 0.03735241023581633 0.051715718389317 7.126089524785047e-07 6.147148725926076 0.2271067314959081 VDDS(ph)PSTSGGSSDGDQR ddPTM_A459_Selumetinib_30min_R1 1 VDDSPSTSGGSSDGDQR 17 0 F8WF15;F8W8F0;C9J180;Q96LR5 F8WF15 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 1 VDDS(0.963)PS(0.03)T(0.003)S(0.003)GGSSDGDQR 208.38 4.709e-09 6096600.0 873.37 887.22 557.65 818.24 1002.3 756.19 976.27 1038.4 346.27 725.88 True False 893.7178217178098 783.3438699426122 481.9241929521874 675.3497442670853 911.6421419704375 748.5834151655856 902.6291679005133 1010.858258801435 587.5948994398302 819.0537686699537 1.0911589152066312 0.9564010323945763 0.5883913991810028 0.824548729399992 1.1130430953890076 0.9139612609086659 1.102038965483641 1.2341781424715854 0.7174069907449602 1.0 9.677814353786616 -6.248162373683444 24.18717091040322 1.024603187425996 0.8518780330277262 0.14476864335842554 0.17415755687229506 926.2874487749448 1687446.8384897907 0.052500778515441396 0.06733685445428875 5.647257960952472e-07 6.248162373683444 -0.17272515439826974 VDDS(ph)PSTSGGSSDGDQR ddPTM_A459_Selumetinib_30min_R2 1 VDDSPSTSGGSSDGDQR 17 0 F8WF15;F8W8F0;C9J180;Q96LR5 F8WF15 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 1 VDDS(0.821)PS(0.157)T(0.021)S(0.001)GGSSDGDQR 142.74 0.00049809 8559400.0 15956.0 14387.0 15980.0 15949.0 17587.0 17421.0 15901.0 16986.0 13194.0 11919.0 True False 15069.229396928822 15490.436638503741 14951.864197708466 13776.71868644041 15377.56383022515 19820.584617907414 16640.42800723375 17035.426447816324 15833.168671161804 11574.867500718909 1.3018921725015755 1.3382819835770594 1.2917525143834099 1.190226901999936 1.328530441430112 1.7123811237300444 1.437634427020458 1.4717599529116219 1.367892001370937 1.0 13.498708058378387 -6.538134492307449 24.984272424506504 1.4399615682589393 1.282203217919022 0.07156254339811507 0.16913677474674743 426.06269877035817 697756.1576976029 0.05312135384159178 0.053139226733851914 2.8964464773062316e-07 6.538134492307449 -0.15775835033991736 VDDSPSTSGGS(ph)SDGDQRESVQQEPER ddPTM_A459_Selumetinib_30min_R1 2 VDDSPSTSGGSSDGDQRESVQQEPER 26 1 F8WF15;F8W8F0;C9J180;Q96LR5 F8WF15 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 1 VDDSPS(0.008)T(0.031)S(0.031)GGS(0.465)S(0.465)DGDQRESVQQEPER;VDDSPS(0.005)T(0.015)S(0.008)GGS(0.505)S(0.466)DGDQRESVQQEPER 110.91 1.0465e-08 13576800.0 1029.59 1022.65 1443.56 1296.42 1424.73 1106.43 1041.1100000000001 905.6700000000001 691.72 804.9000000000001 True False 1053.5774437666053 902.9176625829127 1247.532480907486 1070.0245838173826 1295.863423056512 1095.3003187580614 962.57823449753 881.648689569236 1173.7983187700902 908.2167553899351 1.16005065697589 0.994165387529382 1.3736065465692366 1.178159924343145 1.4268217530298084 1.2059899933114575 1.0598551819100226 0.9707469988160565 1.292420902613859 1.0 9.826892842585185 -7.215087439159903 6.102014985102674 1.0783231918001512 1.2275603923147578 0.20682804274659683 0.13663310381796165 0.3487963625882267 33.27130628590103 0.05388708814431298 0.041061682242461844 6.094141878080668e-08 7.215087439159903 0.14923720051460654 VDDSPSTSGGSS(ph)DGDQR ddPTM_A459_Selumetinib_30min_R1 1 VDDSPSTSGGSSDGDQR 17 0 F8WF15;F8W8F0;C9J180;Q96LR5 F8WF15 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 1 VDDSPSTSGGS(0.046)S(0.954)DGDQR 244.54 4.0084e-23 17640000.0 3901.2 5023.0 3188.9 3344.7 3537.5 3635.0 4529.6 4264.1 1883.4 3466.6 True False 3992.0903695862226 4434.904824870651 2755.8648953738552 2760.6109327949257 3217.5337495963527 3598.4352003159274 4187.928625198121 4151.002216251153 3195.992241906537 3911.5718775434802 1.0205846893687427 1.133790957627968 0.7045415453555657 0.7057548778903243 0.8225679727549854 0.9199460761477284 1.070651072332639 1.0612107731120202 0.8170608496944362 1.0 11.933532760283354 -7.008790452055364 21.05639645826672 0.9927555007352925 0.8724160081659059 0.12246467306849229 0.13798128647448504 117.71391404392497 281970.8004387132 0.055472028396393605 0.046374059541196 9.799627052947344e-08 7.008790452055364 -0.12033949256938659 VDDSPSTSGGSS(ph)DGDQR ddPTM_A459_Selumetinib_30min_R2 2 VDDSPSTSGGSSDGDQR 17 0 F8WF15;F8W8F0;C9J180;Q96LR5 F8WF15 UBE2E2 Ubiquitin-conjugating enzyme E2 E2 1 VDDSPST(0.001)SGGS(0.188)S(0.811)DGDQR;VDDSPSTSGGS(0.024)S(0.976)DGDQR 286.85 1.429399999999999e-75 27889000.0 35580.5 33926.7 41056.6 42768.7 50426.1 41344.2 39761.8 45589.0 38208.1 39968.1 True False 33603.07825002671 36528.76879846565 38415.06305504614 36943.52927987734 44091.12250294629 47038.988264720065 41610.802486511995 45721.65644233479 45850.78762351195 38814.11710340496 0.865743723102203 0.9411206933072599 0.9897188425722606 0.9518065084787533 1.1359558272440622 1.211904115695925 1.0720533041021225 1.17796461324954 1.1812915260022672 1.0 15.244293850797877 -6.252037786006491 5.08599660345025 1.140741778383834 0.9394997312503004 0.6857579716189723 0.06371941965825309 0.10130044804544759 8.334234781397312 0.018941583182201262 0.023383983331027983 5.597089016263703e-07 6.252037786006491 -0.20124204713353366 VDDSS(ph)EDKTEFTVK ddPTM_A459_Selumetinib_30min_R1 1 VDDSSEDKTEFTVK 14 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 VDDS(0.055)S(0.945)EDKTEFTVK 161.04 3.989e-05 0.0 627.36 812.82 859.17 906.4 596.96 748.76 877.45 622.64 559.96 697.59 True False 641.9762673699412 717.6546565302336 742.4994330829923 748.1142552352441 542.965073401848 741.2281542196849 811.2632400609522 606.1255645802436 950.2112221397379 787.1324716020184 0.8155885959873479 0.9117330086378225 0.943296662087658 0.9504299240922406 0.6898013904784965 0.94168158596112 1.030656553159116 0.7700426376091702 1.2071808195205211 1.0 9.620462646397328 -8.263686091629365 24.989027911570197 1.1035904078957968 0.8875763400771912 0.4151878788489023 0.10517200584843084 199.11341484905495 2214556.353610906 0.08457313061940204 0.025911550035763446 5.4489636202949455e-09 8.263686091629365 -0.21601406781860555 VDDSTGTVIS(ph)DVEEDAGELSR ddPTM_A459_Selumetinib_30min_R1 5 VDDSTGTVISDVEEDAGELSR 21 0 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 1 VDDSTGTVIS(1)DVEEDAGELSR;VDDST(0.001)GT(0.001)VIS(0.998)DVEEDAGELSR;VDDSTGTVIS(1)DVEEDAGELSR;VDDS(0.001)T(0.181)GT(0.367)VIS(0.451)DVEEDAGELSR;VDDSTGT(0.001)VIS(0.998)DVEEDAGELSR 254.8 1.5492e-39 22198200.0 2060.12 2726.46 2634.5600000000004 2592.66 2783.9700000000003 1969.53 2493.39 2065.97 958.512 1658.05 True False 2108.11678770429 2407.2447957031327 2276.8012226021974 2139.900601255745 2532.160405049824 1949.7183163901593 2305.3115848601947 2011.1737643836664 1626.5248570533704 1870.8768682746684 1.126806805649591 1.286693334298962 1.216970107018253 1.143795531145335 1.3534618167495942 1.0421414415092956 1.2322091442533918 1.0749899143487622 0.8693917192708462 1.0 10.8694988954187 -7.999672090106796 3.6677145261418875 0.9379109762688481 1.2013394296579993 0.6003984327288154 0.08668512175996337 0.145538876983889 4.184167690526333 0.05679084328660054 0.021925993237064206 1.0007553255467166e-08 7.999672090106796 0.2634284533891512 VDDSTGTVIS(ph)DVEEDAGELSR ddPTM_A459_Selumetinib_30min_R2 2 VDDSTGTVISDVEEDAGELSR 21 0 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 1 VDDS(0.001)T(0.002)GT(0.027)VIS(0.97)DVEEDAGELSR;VDDST(0.002)GT(0.006)VIS(0.992)DVEEDAGELSR 174.15 5.2197e-11 2402000.0 9445.3 8060.900000000001 8602.6 8306.1 9608.8 7462.6 7756.2 8192.4 8230.8 7450.2 True False 8920.368038531702 8679.14511012128 8049.1180818026905 7174.794851178295 8401.6566402381 8490.50541126204 8116.878668618727 8216.23852767517 9877.189987767051 7235.093368055718 1.2329306043121413 1.1995899249125546 1.1125106024672802 0.9916658274040178 1.1612367958280918 1.1735170479968096 1.1218761466792198 1.1356091911614286 1.3651779576717946 1.0 12.820795919354374 VDEDSAEDT(ph)QSNDGKEVVEVGQK ddPTM_A459_Selumetinib_30min_R2 1 VDEDSAEDTQSNDGKEVVEVGQK 23 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 VDEDS(0.018)AEDT(0.828)QS(0.154)NDGKEVVEVGQK 88.071 0.00030367 12580000.0 67443.0 51170.0 62660.0 55400.0 54461.0 49513.0 73379.0 70300.0 52569.0 57032.0 True False 63694.78805572007 55094.574462517354 58628.523819049595 47854.42442966944 47619.122292482585 56332.96631573674 76791.26889773007 70504.56136120857 63084.268900583935 55385.33797306829 1.1500297802045072 0.9947501717748419 1.0585567582445436 0.8640269461376071 0.8597784907557645 1.0171097329609011 1.3864909325834691 1.2729824163119159 1.1390066614969352 1.0 15.757216485189147 -7.10071128595147 7.59573717688085 1.2214896163099531 0.9789288963997645 0.4095622738227498 0.12209122697888643 0.2556806177888487 17.09172378352631 0.047450116881153026 0.03675683187598853 7.930283515408083e-08 7.10071128595147 -0.24256071991018857 VDEDSAEDTQS(ph)NDGK ddPTM_A459_Selumetinib_30min_R2 2 VDEDSAEDTQSNDGK 15 0 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 VDEDSAEDT(0.036)QS(0.964)NDGK;VDEDSAEDT(0.006)QS(0.994)NDGK 212.59 7.2112e-07 15474300.0 79886.0 48587.0 67925.0 72215.0 66479.0 74004.0 123113.0 110881.0 94654.0 50545.0 True False 75446.2559289957 52313.46666817136 63554.779451148184 62379.1924221766 58127.31369019947 84197.37925857419 128837.99844378153 111203.64535266237 113587.4448537328 49085.63451831842 1.537033322872493 1.0657592018831565 1.2947735131636118 1.2708237967036389 1.1842021451002485 1.7153161018454863 2.6247597633825044 2.2655028593174635 2.3140669560122067 1.0 15.583013244382826 -6.979089400226856 4.503964643807398 2.1622287118062142 1.2675862449960593 0.43082495400075493 0.4154605877276231 0.15731082886925787 7.835264656297871 0.1451766194018774 0.1224763138083373 1.0493264008685756e-07 6.979089400226856 -0.8946424668101549 VDEDSAEDTQS(ph)NDGKEVVEVGQK ddPTM_A459_Selumetinib_30min_R1 1 VDEDSAEDTQSNDGKEVVEVGQK 23 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 VDEDSAEDT(0.333)QS(0.667)NDGKEVVEVGQK 99.569 2.8967e-05 12440000.0 1057.2 1117.4 901.99 826.82 792.93 1017.3 1103.9 1117.9 578.4 1156.5 True False 1081.8307030468968 986.574288534833 779.5047122764157 682.4314083336324 721.2096215031613 1007.0668856344963 1020.6319342450116 1088.2496605490405 981.5025553354251 1304.9480402639579 0.8290220527309807 0.7560257252352164 0.5973454024412663 0.5229567670721923 0.552673056129713 0.7717294900345552 0.7821245771889612 0.833940989963796 0.7521391848957388 1.0 10.34977664812706 -6.9405712978594645 5.92570089657492 0.8216136949078294 0.6473747772329351 0.42009246299681724 0.10499111055847012 0.22925689676586564 16.157780689232712 0.04032020063942581 0.03532368999142487 1.1466442620825117e-07 6.9405712978594645 -0.1742389176748943 VDEDSAEDTQS(ph)NDGKEVVEVGQK ddPTM_A459_Selumetinib_30min_R2 1 VDEDSAEDTQSNDGKEVVEVGQK 23 1 Q9H2G2-2;Q9H2G2 Q9H2G2-2 SLK STE20-like serine/threonine-protein kinase 1 VDEDSAEDT(0.27)QS(0.73)NDGKEVVEVGQK 94.234 4.8121e-05 15588000.0 66674.0 41755.0 48612.0 52245.0 44486.0 49614.0 64821.0 61953.0 47554.0 41474.0 True False 62968.52599716926 44957.474236513815 45484.35684474367 45129.14087234805 38897.27097011406 56447.87814895001 67835.30494037482 62133.272973128755 57066.12876977625 40276.537857606876 1.563404635715893 1.116219929216753 1.129301555301214 1.1204821286252806 0.9657550782450802 1.4015077052678924 1.6842387292621532 1.5426666808550895 1.416857848396182 1.0 15.297652055189811 -6.940698232550375 9.239312916120141 1.4684740849338955 1.1702604855949186 0.1990402917135755 0.21855674262100164 0.41596663123567007 60.740341134155635 0.07529407766942232 0.06637452740926958 1.146309172246566e-07 6.940698232550375 -0.29821359933897695 VDEFPLCGHMVSDEYEQLSSEALEAAR ddPTM_A459_Selumetinib_30min_R1 1 VDEFPLCGHMVSDEYEQLSSEALEAAR 27 0 X1WI28;P27635;B8A6G2;A6QRI9 X1WI28 RPL10 60S ribosomal protein L10 0 121.35 1.5815e-10 3464900.0 1401.3 1134.3 1456.7 1515.2 1813.3 1108.4 1684.1 1350.9 624.33 951.24 False True 1433.947563544851 1001.4956286782359 1258.8881410803397 1250.5987638266133 1649.2873351641174 1097.2505023466783 1557.0669811233115 1315.0697436583755 1059.4424107409511 1073.3409198622458 1.3359665480087035 0.9330638664244436 1.172868860009462 1.1651458923108207 1.5365922463626835 1.0222758510758176 1.4506732691446702 1.2252115980327607 0.987051169983272 1.0 10.067892669494139 -8.260098755638259 22.535629932600308 0.9935255117150485 1.2268671627178387 0.23414572609223927 0.17114653655849618 43.50840405061911 731522.8757053029 0.12975621728198358 0.042770402918078786 5.49415926173207e-09 8.260098755638259 0.23334165100279014 VDEGAGDSAAVASGGAQTLALAGS(ph)PAPSGHPK ddPTM_A459_Selumetinib_30min_R1 2 VDEGAGDSAAVASGGAQTLALAGSPAPSGHPK 32 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 VDEGAGDSAAVASGGAQT(0.001)LALAGS(0.99)PAPS(0.009)GHPK;VDEGAGDSAAVASGGAQTLALAGS(0.987)PAPS(0.013)GHPK 162.12 3.2691e-24 15506300.0 2878.2 2884.0 2696.4700000000003 3204.6 3146.3999999999996 2480.77 2985.0 2565.8 987.9300000000001 2119.12 True False 2945.2564599977086 2546.3399392647743 2330.304184649485 2644.976767792215 2861.808675542037 2455.815706158941 2759.8390467627128 2497.7466491070118 1676.4450544476595 2391.1296939767894 1.2317426643217029 1.0649108434724208 0.9745620200022931 1.1061619846279613 1.196843769181939 1.027052490019715 1.1541988097570346 1.0445885287606056 0.7011100479704605 1.0 11.223476668071184 -8.079226101540453 6.787313884369462 0.8532430457296519 1.1013244245902285 0.5151793250047731 0.09829745171768135 0.19683706772112475 14.133568582376734 0.06420730348445813 0.024026745746036922 8.332472681203682e-09 8.079226101540453 0.24808137886057657 VDEGAGDSAAVASGGAQTLALAGS(ph)PAPSGHPK ddPTM_A459_Selumetinib_30min_R2 2 VDEGAGDSAAVASGGAQTLALAGSPAPSGHPK 32 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 VDEGAGDSAAVASGGAQT(0.005)LALAGS(0.944)PAPS(0.051)GHPK;VDEGAGDSAAVASGGAQTLALAGS(0.972)PAPS(0.028)GHPK 130.49 6.128100000000001e-19 16728100.0 57992.0 41997.0 73315.0 79504.0 87298.0 50039.0 54638.0 60472.0 53603.0 66590.0 True False 54769.036800369555 45218.03485836115 68597.99271933647 68675.41804795004 76330.84478597791 56931.41804118416 57178.77526314306 60647.96350832151 64325.09779295783 64667.373678401855 0.846934608365915 0.6992403168131667 1.0607821041330985 1.061979389939054 1.1803609833542925 0.8803731279440932 0.8841981978037265 0.9378448521804933 0.9947071318042665 1.0 15.980750399273651 -5.263157976526525 24.99867088775017 0.9980533562131253 0.7730874557703221 0.4992662700804953 0.09089334852458042 127.32972222398188 1852168.3659923233 0.025883058137993395 0.058761870118159934 5.455593753728973e-06 5.263157976526525 -0.22496590044280318 VDENENCSSLGS(ph)PSEPPQTLDLVR ddPTM_A459_Selumetinib_30min_R1 1 VDENENCSSLGSPSEPPQTLDLVR 24 0 A0A0C4DGQ6;Q96P16-3;Q96P16 A0A0C4DGQ6 RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1A 1 VDENENCSSLGS(0.98)PS(0.02)EPPQTLDLVR 170.87 3.4924e-16 9707100.0 932.72 950.92 822.94 895.19 935.91 892.69 940.3 924.51 561.04 761.08 True False 954.4505612428131 839.5858443292854 711.189268085848 738.8618712974828 851.2571057483309 883.710349097669 869.3724139601269 899.9889915682921 952.043903259659 858.7720315469893 1.1114131878788238 0.977658579328507 0.8281467513616085 0.8603702078728616 0.9912492192076621 1.029039508314862 1.0123436511946506 1.0479952286604568 1.1086107468412194 1.0 9.746131396102395 -6.582346509638663 3.756990654737337 1.040563165815384 0.9371341902609734 0.25546163216926254 0.07571822356970558 0.3282477392433817 9.48176357036044 0.02792891534360015 0.028450527061281938 2.6160948771028135e-07 6.582346509638663 -0.10342897555441055 VDENENCSSLGS(ph)PSEPPQTLDLVR ddPTM_A459_Selumetinib_30min_R2 2 VDENENCSSLGSPSEPPQTLDLVR 24 0 A0A0C4DGQ6;Q96P16-3;Q96P16 A0A0C4DGQ6 RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1A 1 VDENENCSSLGS(0.899)PS(0.101)EPPQTLDLVR;VDENENCSSLGS(0.987)PS(0.013)EPPQTLDLVR 177.43 2.7728e-20 8370300.0 22842.2 17348.9 23575.4 23072.1 25565.6 23605.8 24460.0 27258.0 21225.4 23233.7 True False 21572.72196857154 18679.504844494186 22058.58443095471 19929.64017840753 22353.820768636153 26857.28467788296 25597.438466570504 27337.316267195176 25471.073087227338 22562.882712597795 0.9561155036508961 0.8278864488385893 0.9776492087439911 0.8832931692402932 0.9907342538351753 1.1903303766627045 1.1344932645631487 1.211605654091869 1.128892677929216 1.0 14.461663782812824 -6.598060756400765 4.029489384186901 1.1457504699568921 0.911920668804501 0.7197910932857668 0.06534796987416491 0.10542901336795514 3.351830674474361 0.020868791626772923 0.021052023338238853 2.5231277703317916e-07 6.598060756400765 -0.23382980115239116 VDENENCSSLGSPS(ph)EPPQTLDLVR ddPTM_A459_Selumetinib_30min_R1 1 VDENENCSSLGSPSEPPQTLDLVR 24 0 A0A0C4DGQ6;Q96P16-3;Q96P16 A0A0C4DGQ6 RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1A 1 VDENENCSSLGS(0.263)PS(0.737)EPPQTLDLVR 213.05 2.6068e-32 8410200.0 715.72 1040.6 743.83 649.72 884.63 973.83 770.34 890.15 399.21 1012.7 True False 732.3948834513102 918.7660682381851 642.821971565723 536.2585987549019 804.6153726941119 964.0341543668944 712.232633595708 866.5403303853012 677.4302128552132 1142.6899095333424 0.6409393111298317 0.8040379639069322 0.5625515428137822 0.46929494544491246 0.7041414875385614 0.8436533361536304 0.6232947605939508 0.7583337554273 0.5928381857610571 1.0 10.158218238806269 -6.510303783555522 24.880731840318372 0.7435435301700187 0.6231560741114662 0.20329957335445292 0.13174337556659088 1101.7423949531542 2179904.9246098055 0.04164835421753249 0.04495256872934752 3.088134565367009e-07 6.510303783555522 -0.1203874560585525 VDENMTASTYS(ph)LNKIPER ddPTM_A459_Selumetinib_30min_R1 2 VDENMTASTYSLNKIPER 18 1 Q9HCD6;Q9HCD6-2;Q9HCD6-3;Q9HCD6-4;J3KRP9 Q9HCD6 TANC2 Protein TANC2 1 VDENMTAS(0.002)T(0.006)YS(0.991)LNKIPER;VDENMTAS(0.005)T(0.351)YS(0.643)LNKIPER 139.16 0.00018078 8070100.0 2954.6 3310.4 3334.8 3977.6 3276.4 3142.5 3216.7 3089.3 2180.8599999999997 3129.1 True False 3023.43643134919 2922.816829036792 2881.9524767451876 3282.9868287993236 2980.0501984954017 3110.8893031617067 2974.0617292199736 3007.3617285393602 3700.760136287718 3530.750465015089 0.8563155230898678 0.8278174450440244 0.8162436018351898 0.929826919610784 0.8440274179734948 0.8810844419582656 0.8423313283362447 0.8517627508197491 1.0481511432079929 1.0 11.785759147219096 -8.25737783239645 24.996984737285963 1.0240755828925698 0.8563186439100626 0.8190921035078186 0.031562450492487515 124.10501417768161 763822.1317567565 0.0230295052235765 0.008007749232476548 5.5286890881642725e-09 8.25737783239645 -0.1677569389825072 VDFGS(ph)SER ddPTM_A459_Selumetinib_30min_R1 1 VDFGSSER 8 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 VDFGS(0.714)S(0.286)ER 97.565 0.020166 6753000.0 1873.9 2340.2 1710.8 1813.9 2177.8 1999.2 2041.6 2027.0 1154.6 2073.7 True False 1917.558224025331 2066.2082960705366 1478.4827567517289 1497.136416120046 1980.8183745218182 1979.089863128364 1887.6004682984105 1973.2373753760653 1959.2718713524928 2339.879594548523 0.8195114947336943 0.8830404354499313 0.6318627506288418 0.6398348101364236 0.846547138210338 0.8458084201166886 0.8067083762327611 0.8433072282750511 0.8373387570528098 1.0 11.192218578224184 -6.470951256017061 23.947478035390176 0.852325577569867 0.7452519804210844 0.31671928443191866 0.08526846069383497 312.4992281581323 144115.28708848704 0.0278430037628033 0.031570562398674215 3.381027817753745e-07 6.470951256017061 -0.10707359714878262 VDFGS(ph)SER ddPTM_A459_Selumetinib_30min_R2 1 VDFGSSER 8 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 VDFGS(0.975)S(0.025)ER 103.26 0.015562 7122700.0 20256.0 16390.0 24522.0 24601.0 24030.0 23644.0 20331.0 18054.0 21377.0 20592.0 True False 19130.252611192675 17647.06029784365 22944.281217534866 21250.30136090792 21011.13656907433 26900.746381137884 21276.431785112214 18106.534150999414 25652.997323285246 19997.455455558673 0.9566343404893075 0.8824652884994083 1.1473600363068726 1.0626502660867783 1.050690504887905 1.345208466193148 1.0639569535432083 0.905441904408211 1.2828130749082134 1.0 14.287528817789834 -5.2608746472823755 24.998904897831377 1.1072254204867658 0.9195498034308843 0.2717377541631104 0.12292170428824448 62.683724698896526 2774621.1463824566 0.03150103447840397 0.07371178985941326 5.484352398473077e-06 5.2608746472823755 -0.18767561705588143 VDFGSS(ph)ER ddPTM_A459_Selumetinib_30min_R1 1 VDFGSSER 8 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 VDFGS(0.24)S(0.76)ER 104.01 0.014949 7585700.0 1603.0 1948.1 1938.3 1910.4 1957.9 1604.4 2158.0 2247.3 1012.0 1448.3 True False 1640.3467811049711 1720.01554635288 1675.0895063197786 1576.784502649393 1780.808290695321 1588.2611926786449 1995.2203225842316 2187.694303740817 1717.2900864444164 1634.2034126366525 1.0037592434459592 1.0525100688523081 1.0250189746068146 0.964864282167531 1.0897102997858348 0.9718870860244481 1.2209130804378312 1.33869155260859 1.050842308347472 1.0 10.67437185452112 -7.263336493872299 24.993806552297617 1.1808360351360958 1.0206978846965824 0.31474746984300683 0.09365083339922002 168.51355722285683 2220077.7334214 0.03627482977822214 0.025855205633467892 5.4533516852262795e-08 7.263336493872299 -0.1601381504395134 VDFGSS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 VDFGSSER 8 0 A0A0C4DGE6;E9PNT2;E9PIR1;A0A0G2JRG8;A0A0G2JNY3;Q6ZUM4-2;Q6ZUM4-3;Q6ZUM4 A0A0C4DGE6 ARHGAP27 Rho GTPase-activating protein 27 1 VDFGS(0.265)S(0.735)ER 96.665 0.020894 8315700.0 28250.0 31208.0 33872.0 25346.0 33080.0 26697.0 33231.0 29697.0 23100.0 27097.0 True False 26679.978093710157 33601.553250463985 31692.71239704513 21893.831075711223 28924.194661047815 30374.269418763255 34776.30734597729 29783.41335339701 27720.645467927643 26314.63920353892 1.0138834846773086 1.2769148378042394 1.20437571466999 0.8320019479030832 1.0991674420205597 1.154272691478832 1.3215574447739493 1.131819179545946 1.0534305735113265 1.0 14.683577993919048 -6.728557420399938 6.563832461613374 1.152341052207148 1.088076708427471 0.018792432925783475 0.1350517582865075 0.7086241419023085 91.06270515573837 0.04773183275195288 0.046761802929064476 1.868282645268708e-07 6.728557420399938 -0.06426434377967705 VDGETAS(ph)DSESR ddPTM_A459_Selumetinib_30min_R2 2 VDGETASDSESR 12 0 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 VDGET(0.238)AS(0.752)DS(0.01)ESR;VDGET(0.009)AS(0.985)DS(0.006)ESR 143.55 0.00081657 9935800.0 18206.8 3255.8999999999996 15836.4 16508.2 7839.0 10696.2 35381.0 24437.0 26788.0 8314.3 True False 17194.93894359511 3505.617060631429 14817.503265368621 14259.754681766603 6854.194738450839 12169.50445956382 37026.286606121444 24508.107624236854 32146.348519257397 8074.24455585429 2.1296034352994413 0.4341727620932234 1.8351566097443854 1.766079115281127 0.8488961030392812 1.5072003795996283 4.585727661577362 3.035343734599551 3.9813444213736937 1.0 12.979111569049866 -7.157288866816157 8.09788807294634 3.3167233692855342 1.374622703610922 0.4242422737063908 0.9798586348078115 0.24800572220346342 17.302962112970622 0.3490663940089866 0.27021744867129077 6.961633137190152e-08 7.157288866816157 -1.9421006656746123 VDGETAS(ph)DSESRAESAPLPVSADDTPEVLNR ddPTM_A459_Selumetinib_30min_R1 1 VDGETASDSESRAESAPLPVSADDTPEVLNR 31 1 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 VDGET(0.064)AS(0.687)DS(0.131)ES(0.114)RAES(0.003)APLPVS(0.001)ADDTPEVLNR 81.569 5.8111e-06 8016900.0 513.75 1001.7 794.41 665.22 959.1 937.86 940.36 1125.8 547.05 796.48 True False 525.7193754165186 884.4204983223036 686.5334853817758 549.0518147259369 872.3495743428585 928.4259799087476 869.4278881118202 1095.9401268862243 928.3038950488315 898.7159663721897 0.5849672144344655 0.984093452676053 0.7639048498860855 0.6109291870514687 0.970662152430914 1.0330582905481107 0.967411196244131 1.219451047821217 1.0329224468950722 1.0 9.81172142269718 -6.45200128897246 5.045779999049883 1.0543347822532803 0.7563610885140136 0.6094082398398484 0.11900094110454043 0.15793724886726226 7.55345604062723 0.037950763697003724 0.04253869709226398 3.531821215568937e-07 6.45200128897246 -0.29797369373926663 VDGETAS(ph)DSESRAESAPLPVSADDTPEVLNR ddPTM_A459_Selumetinib_30min_R2 1 VDGETASDSESRAESAPLPVSADDTPEVLNR 31 1 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 VDGET(0.087)AS(0.706)DS(0.189)ES(0.017)RAES(0.001)APLPVSADDTPEVLNR 73.389 3.5762e-05 5840400.0 11003.0 3848.2 9131.9 8226.4 5656.7 3717.4 9455.2 5897.7 5062.2 9394.4 True False 10391.497308498858 4143.344566086752 8544.363496060952 7105.950128668458 4946.054774460375 4229.438106802657 9894.885535123363 5914.861330583202 6074.781449685859 9123.159262417463 1.1390239948244978 0.45415677255083287 0.9365575290633323 0.7788913822803875 0.5421427635090703 0.46359358476023543 1.0845898060647696 0.6483347665483894 0.6658637950902282 1.0 13.155317787008377 -9.704200146845459 13.607973786463955 0.999992232658451 0.736696056996836 0.09768051945988165 0.23015477451714203 0.0 0.0 0.21292325619360034 0.051641475025686126 1.976058753395665e-10 9.704200146845459 -0.263296175661615 VDGETASDS(ph)ESRAESAPLPVSADDTPEVLNR ddPTM_A459_Selumetinib_30min_R2 1 VDGETASDSESRAESAPLPVSADDTPEVLNR 31 1 O95674 O95674 CDS2 Phosphatidate cytidylyltransferase 2 1 VDGET(0.038)AS(0.096)DS(0.287)ES(0.287)RAES(0.287)APLPVS(0.004)ADDTPEVLNR 54.363 0.0021534 5748300.0 21625.0 4450.1 16814.0 19603.0 10168.0 7469.2 18047.0 9507.9 11329.0 11574.0 True False 20423.169071733893 4791.408360673215 15732.20554569902 16933.03758293882 8890.604936926666 8498.014501353198 18886.22125945207 9535.56641488242 13595.116558707889 11239.828547136563 1.8170356412542306 0.42628838514568484 1.3996837656128593 1.5065209857896498 0.7909911525466835 0.7560626450585971 1.6802944262226747 0.8483729422466753 1.2095483931711177 1.0 13.456332408339392 -4.70686249716933 24.239494852689734 1.0886005123401703 1.8170608977138065 0.2720065502131668 0.3659958907067055 25362.758439735244 11262720.018853126 0.08883777471249264 156.3899916543037 1.9639819986145593e-05 4.70686249716933 0.7284603853736362 VDGIPNDS(ph)SDSEMEDK ddPTM_A459_Selumetinib_30min_R1 1 VDGIPNDSSDSEMEDK 16 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 VDGIPNDS(0.72)S(0.277)DS(0.002)EMEDK 207.21 7.3113e-08 3963000.0 2616.8 3271.1 2026.3 1910.5 2370.2 2630.1 3303.9 3279.2 1655.5 3276.2 True False 2677.76634859357 2888.1180913068665 1751.1395896691788 1576.8670395266254 2155.815828492798 2603.643581939732 3054.6841630148497 3192.224963657224 2809.2625870639645 3696.7321828904273 0.7243603853660449 0.7812624632841766 0.4736993385060384 0.4265570134684989 0.5831679769691062 0.7043094963682158 0.8263201151419174 0.8635261646574744 0.7599313253110584 1.0 11.852034813063769 -7.1022740378797415 2.371012892920533 0.8562261071290987 0.5924010385292586 0.5532004025826676 0.11206713906700971 0.26773554165222935 2.9542302096972244 0.05434697237961478 0.04017540783112277 7.901798706878747e-08 7.1022740378797415 -0.2638250685998401 VDGIPNDS(ph)SDSEMEDK ddPTM_A459_Selumetinib_30min_R2 2 VDGIPNDSSDSEMEDK 16 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 VDGIPNDS(0.498)S(0.498)DS(0.005)EMEDK;VDGIPNDS(0.481)S(0.481)DS(0.037)EMEDK 152.59 0.00016745 17750200.0 108321.0 69753.0 97684.0 95929.0 99626.0 83659.0 102360.0 98937.0 89501.0 84975.0 True False 102300.95246331964 75102.8308087546 91399.1177902976 82863.30471324462 87110.0912122596 95182.26786921066 107119.94282249223 99224.89029009803 107403.70086688269 82521.55095843544 1.2396877091518397 0.9100996035154804 1.1075787685611196 1.0041413879264256 1.0556041446207831 1.1534231575113292 1.298084458888158 1.2024118443929361 1.3015230520931425 1.0 16.332483315885533 -6.9053922558946255 3.724254936420158 1.2185586696440656 1.0541210362193218 0.24863240087277727 0.11051623319508623 0.26326159155396284 7.049011465655527 0.03815093247808651 0.03314407345734432 1.2433910704377498e-07 6.9053922558946255 -0.1644376334247437 VDGIPNDSS(ph)DSEMEDK ddPTM_A459_Selumetinib_30min_R1 3 VDGIPNDSSDSEMEDK 16 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 VDGIPNDS(0.161)S(0.77)DS(0.069)EMEDK;VDGIPNDS(0.216)S(0.78)DS(0.004)EMEDK;VDGIPNDS(0.083)S(0.912)DS(0.005)EMEDK 173.28 4.854e-06 15601300.0 4685.6 8114.0 4159.2 4679.2 5687.7 5295.6 6149.0 6273.3 3189.56 6113.1 True False 4794.765363409515 7164.009107903742 3594.40348485024 3862.0655594624372 5173.248539244997 5242.331072020091 5685.175979411697 6106.911705449766 5412.450363754593 6897.7759316364845 0.6951175873107791 1.038596959209154 0.5210960055058609 0.5599001182031973 0.7499879077715494 0.7600030972267836 0.8242042124529986 0.8853450396149519 0.7846660166113136 1.0 12.751915549505032 -7.331997310230019 1.4868639278020017 0.8841661280620193 0.7127723591379423 0.24278391454191584 0.13821673976403132 0.7129086525733506 3.0569153694861955 0.08927019759454688 0.04992021152932121 4.655889771040963e-08 7.331997310230019 -0.17139376892407698 VDGIPNDSS(ph)DSEMEDK ddPTM_A459_Selumetinib_30min_R2 1 VDGIPNDSSDSEMEDK 16 0 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 VDGIPNDS(0.155)S(0.84)DS(0.005)EMEDK 155.79 8.8443e-05 4150000.0 31651.0 21321.0 26100.0 25328.0 27105.0 21494.0 29970.0 27725.0 23722.0 23554.0 True False 29891.96412899186 22956.252142179626 24420.754415531348 21878.28270676295 23699.827578225555 24454.603396894676 31363.66438442838 27805.675159879167 28467.06284805972 22873.934819358452 1.3068133823522998 1.0035987390657206 1.0676236777095214 0.9564721977019507 1.036106282779478 1.069103483507284 1.3711530015327742 1.2156052458603201 1.244519715251079 1.0 14.481416941892164 -7.125440350423344 10.95075464680272 1.225714612140155 1.0622555523553934 0.21921733217717743 0.12153570523604654 0.5877087537901655 49.3472398313911 0.04482531775990588 0.03472212806217072 7.491342437044635e-08 7.125440350423344 -0.1634590597847616 VDHGAEIITQS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 VDHGAEIITQSPGR 14 0 A0A669KB77;P11137-2;P11137-4;P11137-3;P11137 A0A669KB77 MAP2 Microtubule-associated protein 2 1 VDHGAEIIT(0.055)QS(0.945)PGR 96.561 0.0077464 4541200.0 4020.1 4330.9 3954.4 4492.1 4628.5 3710.1 4507.8 3795.7 2268.3 3830.0 True False 4113.7605082471 3823.836214619215 3417.41419996437 3707.6390621604583 4209.852992228048 3672.779762501273 4167.773016749402 3695.02570582878 3849.1394299227973 4321.617807359235 0.951902896466648 0.8848159150278506 0.7907719637180534 0.8579284951683513 0.9741382000646 0.8498622335938494 0.9644011114662079 0.8550098297763772 0.8906709481269123 1.0 12.077355774303188 VDHGAEIITQS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 VDHGAEIITQSPGR 14 0 A0A669KB77;P11137-2;P11137-4;P11137-3;P11137 A0A669KB77 MAP2 Microtubule-associated protein 2 1 VDHGAEIIT(0.055)QS(0.945)PGR;VDHGAEIIT(0.009)QS(0.991)PGR 134.33 0.00043219 51017000.0 174876.0 139813.0 189849.0 198660.0 216319.0 118446.0 125200.0 164704.0 135467.0 142760.0 True False 165157.09200409421 150536.20753034865 177634.32203196184 171602.1652923853 189143.07330360348 134760.8613542658 131022.04807909338 165183.26137178487 162564.1852642318 138638.14786497442 1.1912817254666999 1.0858209652148718 1.281280259203747 1.237770180394475 1.3642931344395768 0.9720330473941062 0.9450649052719697 1.19147048568958 1.1725790323061729 1.0 17.080964760505516 -6.771811198900258 24.999967139237448 1.0612486232579919 1.227011689438563 0.4410028958988145 0.09883330260911997 234.9283681437525 566262.0771938185 0.03747725854351484 0.03340257445372542 1.6911759778019875e-07 6.771811198900258 0.16576306618057113 VDIDAPDVDVHGPDWHLK ddPTM_A459_Selumetinib_30min_R1 3 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 ;; 138.05 0.00019063 72855300.0 17471.1 17291.0 19831.299999999996 18881.600000000002 18720.600000000002 16094.8 15116.5 15361.7 10181.300000000001 12950.499999999998 False True 17878.142637157252 15266.561681632193 17138.31838553341 15584.283011528898 17027.325035390382 15932.900924909167 13976.250234636036 14954.257814166021 17276.9224872693 14612.822823552418 1.223455786266149 1.0447373423994508 1.1728273580317754 1.0664799812949703 1.165231744817049 1.0903369675590053 0.9564373977154929 1.0233654369683653 1.1823124591248027 1.0 13.834947276388068 -7.00534283768282 24.213305431341517 1.0397489746968538 1.1278905141093996 0.27064623271206256 0.07235031406441715 222.02609947059963 1006207.8167648768 0.025140470482290733 0.02151921108965522 9.877730259929944e-08 7.00534283768282 0.08814153941254577 VDIDAPDVDVHGPDWHLK ddPTM_A459_Selumetinib_30min_R2 2 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 ; 117.48 0.0005742000000000001 12018700.0 96688.0 100520.0 96076.0 105106.0 86916.0 84442.0 85756.0 88553.0 77024.0 90798.0 False True 91314.46803273099 108229.56077725696 89894.57475963936 90790.38148203674 75996.8350411014 96073.11901184426 89743.82392229029 88810.67456926176 92430.95223037497 88176.42581846452 1.0355882219667987 1.2274205919854062 1.0194853547898632 1.0296446089678637 0.8618724827604357 1.0895556053682338 1.0177757046656972 1.0071929514596454 1.0482501572548377 1.0 16.42810537886099 -5.408935824007099 8.418874116332042 1.0072318495166002 1.131192144551984 0.33060737528420225 0.06975917435408077 0.3134155685839533 21.130832878128754 0.017622776000461277 0.03678821464974937 3.899996129284927e-06 5.408935824007099 0.12396029503538375 VDIDAPDVEVHDPDWHLK ddPTM_A459_Selumetinib_30min_R1 2 VDIDAPDVEVHDPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 ; 146.78 0.00013314 11720300.0 7954.2 7820.1 10183.2 9913.5 8748.7 9012.9 7687.5 7748.1 5188.6 7033.0 False True 8139.517383821063 6904.519056534143 8800.377372313662 8182.293324442398 7957.381629708435 8922.238409058442 7107.625685758242 7542.595218624224 8804.675239649698 7935.754057221277 1.0256766181424646 0.870052046314522 1.108952887004557 1.0310668986769793 1.002725333009467 1.1243088362774418 0.8956459127271635 0.950457280333771 1.1094944697331857 1.0 12.954151599458775 -5.258174123081718 24.999906366279998 1.0240056817004306 0.9478643435487264 0.14496135710336322 0.07723935445205826 560.0109961636825 4287583.411051761 0.019706007402853744 0.04775015369210599 5.518561374661713e-06 5.258174123081718 -0.07614133815170421 VDIDAPDVEVHDPDWHLK ddPTM_A459_Selumetinib_30min_R2 1 VDIDAPDVEVHDPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 123.42 0.00050094 1238000.0 15384.0 16266.0 14508.0 18141.0 15264.0 10938.0 17953.0 14213.0 11381.0 16998.0 False True 14529.018867031404 17513.549896566485 13574.571075116053 15670.164505029496 13346.399858108633 12444.610214721963 18787.85007319461 14254.357476911184 13657.51801170929 16507.223573892108 0.8801612701248294 1.0609627850601107 0.8223412625600861 0.9492913472022934 0.808518755341592 0.7538887541575683 1.1381593027497097 0.8635224096350118 0.8273661497691275 1.0 14.010809866668387 -10.297390497670456 18.293651772928254 0.9999999969030313 0.9032153243845037 0.06471613989023672 0.11308073532991762 0.0 0.0 0.1083535373920125 0.026279592916269436 5.042077332239024e-11 10.297390497670456 -0.09678467251852763 VDIDT(ph)PDIDIHGPEGK ddPTM_A459_Selumetinib_30min_R1 2 VDIDTPDIDIHGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDIDT(1)PDIDIHGPEGK;VDIDT(1)PDIDIHGPEGK 128.38 0.0012996 20638000.0 9765.1 9936.1 6953.1 6131.4 8730.7 6827.1 7135.1 8714.9 4850.6 7975.9 True False 9992.607830423063 8772.77679283243 6008.90721064441 5060.666090632586 7941.009726530276 6758.4255725108305 6596.893662498037 8483.752542015238 8231.113926192975 8999.684456845049 1.1103286874489038 0.9747871533606898 0.6676797658249128 0.5623159472867414 0.8823653500974072 0.7509625037320564 0.7330138844457509 0.942672221753575 0.9146002802278796 1.0 13.135658703823808 -7.783882601029917 22.099165545870015 0.9464778361808743 0.8031719974630263 0.15836777391706203 0.14764201779226507 134.026257116074 131964.33871102103 0.08739416282654804 0.042071352524518185 1.6448162917037115e-08 7.783882601029917 -0.14330583871784808 VDIDT(ph)PDIDIHGPEGK ddPTM_A459_Selumetinib_30min_R2 2 VDIDTPDIDIHGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDIDT(1)PDIDIHGPEGK;VDIDT(1)PDIDIHGPEGK 132.62 0.00081924 15363400.0 106936.0 111619.0 105573.0 124679.0 141011.0 88901.0 118433.0 113488.0 93726.0 105998.0 True False 100992.92521872518 120179.8183883472 98780.54811919143 107697.50511672859 123295.93752566537 101146.30578707231 123940.36917053726 113818.23129105014 112473.8189232463 102937.56232412161 0.98110857629139 1.1675020825724873 0.959616158464673 1.0462410677418146 1.197774017004997 0.9825986112687501 1.2040344299225163 1.105701638170412 1.0926411737738426 1.0 16.65140999787647 -6.043436276633103 24.973384999446232 1.1038454331629624 1.041503178924442 0.10089184702671539 0.08408494308552268 1000.5279303709324 575244.6720701809 0.02345245704924976 0.03027900895535795 9.048231913252451e-07 6.043436276633103 -0.062342254238520356 VDIDT(ph)PDINIEGSEGK ddPTM_A459_Selumetinib_30min_R1 2 VDIDTPDINIEGSEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDIDT(1)PDINIEGSEGK;VDIDT(1)PDINIEGSEGK 139.49 0.00094005 15143300.0 4542.299999999999 3736.9 3958.7 3809.3 4345.200000000001 2693.8 3125.0 3472.0 2289.3 3059.3 True False 4648.126752222778 3299.3820107623214 3421.130283582577 3144.07726441705 3952.1774272073667 2666.702817774705 2889.2787340480672 3379.911281354563 3884.7748961434822 3451.9909551055116 1.3465060635075465 0.9557910358607745 0.9910600369687262 0.9108011305090311 1.144897967175168 0.7725115310139034 0.836989080106021 0.9791193908998104 1.1253722697036275 1.0 11.753212969039465 -4.760874482746064 24.96105639430213 0.9620314275463888 1.3465065105285097 0.5230606243304606 0.10812656657686076 10.92821199912371 482457.4799352514 0.027368666239396804 0.1576057208973631 1.7343051640749785e-05 4.760874482746064 0.38447508298212085 VDIDT(ph)PDINIEGSEGK ddPTM_A459_Selumetinib_30min_R2 2 VDIDTPDINIEGSEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDIDT(1)PDINIEGSEGK;VDIDT(1)PDINIEGSEGK 125.45 0.0028158 1571100.0 21467.2 16779.2 17043.3 24121.4 24421.0 14356.4 20263.5 21374.4 12504.0 17161.1 True False 20274.13896401042 18066.1106863684 15946.75263334198 20836.023708264067 21353.015653489972 16333.863785576375 21205.792901363515 21436.595965277585 15005.149390950963 16665.61445310742 1.2165251404955049 1.0840350793666564 0.9568655676159961 1.250240353686992 1.2812618288735556 0.9800937032076134 1.2724279060355645 1.2862769642004157 0.9003658060836244 1.0 14.02458688944339 -8.274669246739858 24.9439048654044 0.9501828738068703 1.160270137239843 0.34820546840225886 0.1178845188423851 1026.2423335277851 1934880.557314426 0.11388613805844089 0.03009964523550002 5.312889132013125e-09 8.274669246739858 0.21008726343297268 VDIDTPDIDIHGPEGK ddPTM_A459_Selumetinib_30min_R2 1 VDIDTPDIDIHGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 77.726 0.03839 1471500.0 12473.0 9787.4 12049.0 10071.0 10682.0 9133.3 10947.0 9873.3 8852.4 8230.5 False True 11779.800593375114 10538.062108548806 11273.780457959288 8699.312426555982 9340.031661708363 10391.329171157447 11456.057191068989 9902.029668387197 10623.127356722196 7992.864079592841 1.4737896799034746 1.3184337933950727 1.4104806919891446 1.0883848818056128 1.1685462893776803 1.3000758010746487 1.4332856254015724 1.2388587582352093 1.3290764425539112 1.0 12.964496840760162 -5.709326967026591 24.999934099442548 1.2423097734056474 1.3926551251833477 0.301909064956554 0.12149341416100246 149.69184095232856 71810.44444018774 0.0334016971865654 0.05785336856637329 1.9528686471322145e-06 5.709326967026591 0.15034535177770025 VDIDVPDVNIEGPEGK ddPTM_A459_Selumetinib_30min_R2 2 VDIDVPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 ; 187.97 1.2314e-05 4143900.0 39059.0 34628.0 42673.0 40672.0 32252.0 28360.0 42943.0 37687.0 30047.0 35277.0 False True 36888.25714556548 37283.85625343072 39927.465638849426 35132.40343688657 28200.21542346173 32266.33257355228 44939.93458994019 37796.66293058127 36057.23958332565 34258.46134934652 1.0767633948705966 1.0883108810180673 1.165477492748256 1.0255102550762023 0.8231605948642421 0.9418500219411564 1.3117908049538662 1.1032796407624488 1.0525061010661367 1.0 15.064172736648077 -10.11327817710616 15.367930269773687 1.0000018138801228 1.065450801566681 0.025268740055196748 0.12186665861032725 0.0 0.0 0.1284457260594476 0.031152664453073735 7.704098431031619e-11 10.11327817710616 0.06544898768655827 VDIEGPDVNIEGPEGK ddPTM_A459_Selumetinib_30min_R2 1 VDIEGPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 174.95 2.8105e-05 2629100.0 14126.0 13617.0 15649.0 18647.0 14791.0 12234.0 14865.0 13272.0 12998.0 13748.0 False True 13340.933470858397 14661.380114443984 14642.160377342929 16107.246432130809 12932.822346782288 13919.122450805311 15556.251954438705 13310.619322702127 15597.963194464235 13351.059518406219 0.999241554759466 1.0981435663762351 1.0967039999452295 1.2064395645847297 0.9686738591010448 1.042548153696412 1.1651698453588897 0.9969710122519985 1.168294034863702 1.0 13.70466661594143 -6.274693099347635 24.91542770466783 1.061482999730606 1.0997452703116846 0.06704117863373193 0.07782677548178137 2609.5517924991454 4905635.984111457 0.023802421485745934 0.027105227148299056 5.312597342027526e-07 6.274693099347635 0.03826227058107867 VDINT(ph)PDVDVHGPDWHLK ddPTM_A459_Selumetinib_30min_R1 1 VDINTPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDINT(1)PDVDVHGPDWHLK 144.4 0.00022305 13250000.0 7778.9 7041.9 7934.1 7051.4 7664.1 5853.5 6136.3 6337.4 3741.8 5867.1 True False 7960.1332348954875 6217.431074309503 6856.692798891686 5820.005361171448 6970.883508206753 5794.61910455276 5673.433950636528 6169.311565223625 6349.561309740829 6620.19943539357 1.2024008207876986 0.9391606906990224 1.035722996838094 0.8791284036030631 1.0529718290567383 0.8752937371603928 0.8569883741424239 0.9318921016549194 0.9591193394860843 1.0 12.692658963948258 -2.3668991250506615 1.3372113194743938 0.9383244317475503 199.99999785087263 0.5681671440458701 0.06522834577228115 803.2277860318844 2.4756655325716386 0.01853547091296487 489333.77448376856 0.004296362081335671 2.3668991250506615 199.06167341912507 VDINT(ph)PDVDVHGPDWHLK ddPTM_A459_Selumetinib_30min_R2 2 VDINTPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDINT(1)PDVDVHGPDWHLK;VDINT(1)PDVDVHGPDWHLK 96.341 0.0029583 62412000.0 160163.0 134701.0 141600.0 172290.0 174819.0 120563.0 163857.0 130432.0 119103.0 126390.0 True False 151261.78164328844 145032.13356801932 132489.61016242334 148823.8047831722 152856.67431831063 137169.45888805317 171476.67517648573 130811.53552582001 142926.9280158699 122740.7922993424 1.2323676490077444 1.1816131446692344 1.0794260626842407 1.2125048404463457 1.2453616393930478 1.1175539632620415 1.3970634535117339 1.0657543680082702 1.164461507363397 1.0 16.905255275739904 -8.687663839161369 1.3561203988035615 1.0028733655866808 1.196672340129666 0.296753713771324 0.08946662570732944 0.8348934240809354 3.072181723216091 0.08286437519343193 0.024756132218843145 2.0527504728371863e-09 8.687663839161369 0.19379897454298511 VDIQTEDLEDGTCK ddPTM_A459_Selumetinib_30min_R2 2 VDIQTEDLEDGTCK 14 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4;H7C5L4 O75369-8 FLNB Filamin-B 0 ; 132.31 0.011336 13463400.0 46676.0 34784.0 36025.0 36213.0 46502.0 31030.0 38930.0 39003.0 35597.0 37059.0 False True 44081.93477883241 37451.82095181165 33707.19072105429 31280.726929090633 40660.0030268454 35304.100837705475 40740.32213833157 39116.49227270575 42717.39466328227 35989.01037915447 1.224872101633712 1.0406460349213844 0.9365967656776178 0.8691744118423728 1.1297894162268063 0.980968925396023 1.1320211839425613 1.0869010250796665 1.1869566351850844 1.0 15.135268811328187 -7.269724028924803 24.444963147024293 1.1087114650733838 1.0237431632522684 0.10067409549466944 0.10210755389963459 1009.9179530706067 2979882.9417896583 0.04329109857460755 0.02974780641773347 5.3737315999952296e-08 7.269724028924803 -0.08496830182111537 VDKETNTETPAPS(ph)PTVVRPK ddPTM_A459_Selumetinib_30min_R2 1 VDKETNTETPAPSPTVVRPK 20 2 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 VDKETNTETPAPS(0.972)PT(0.028)VVRPK 57.147 0.015418 13099000.0 64511.0 53015.0 73659.0 64441.0 70249.0 65162.0 73841.0 72583.0 49652.0 69895.0 True False 60925.73687799419 57081.08002990727 68919.86013385539 55664.024633074514 61423.692585971796 74137.47401825865 77274.75281316564 72794.20451323746 59583.78739279408 67876.9497409805 0.8975909658652569 0.8409493981053887 1.0153647209672008 0.8200725702243442 0.9049271191526072 1.0922334356680494 1.1384535266839082 1.0724436615231132 0.8778206389675249 1.0 16.05063411395807 -6.744246689394175 19.11035166099151 1.0471091421425283 0.8951710787946403 0.42816278532698604 0.08063934070327101 14.497710860809232 16113.687608494112 0.027080399100594132 0.02692419066834573 1.8019938755506692e-07 6.744246689394175 -0.15193806334788795 VDLKS(ph)PQVDIK ddPTM_A459_Selumetinib_30min_R2 1 VDLKSPQVDIK 11 1 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 VDLKS(1)PQVDIK 114.31 0.031314 6413400.0 36721.0 28596.0 27460.0 37537.0 34345.0 21785.0 30795.0 26677.0 21504.0 25833.0 True False 34680.19382580993 30789.221249367696 25693.25349618741 32424.39584506321 30030.274051804325 24785.686005459673 32227.028519134856 26754.625653384894 25805.400871961738 25087.134167805325 1.3823896182735578 1.2272912897671644 1.0241605647073044 1.2924710980608496 1.1970388427364733 0.987983953833495 1.2846038253541234 1.0664679940891568 1.0286308790534622 1.0 14.614660053244318 -1.5228787452803376 0.16896852036902713 0.9981116899181759 2.214408373335805 0.3928397580251606 0.10652403986825697 71.14284507446743 0.7666852770738399 0.28524151789918806 21.83312422288225 0.029999999999999995 1.5228787452803376 1.2162966834176292 VDLTLLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 VDLTLLSPK 9 0 E7EVA0;P27816-4;B5MEG9 E7EVA0 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VDLT(0.004)LLS(0.996)PK 120.57 0.0065363 15597000.0 4174.9 5745.2 6506.3 6412.2 4013.0 5472.9 4896.6 4860.4 3056.7 4223.8 True False 4272.167047058734 5072.5493131289795 5622.7801965476865 5292.429641901403 3650.024858552693 5417.84759499561 4527.2455197247245 4731.486403195772 5186.996647465064 4765.965873296071 0.8963906080393663 1.064327661587069 1.1797776874677988 1.1104631847145892 0.7658520760721248 1.1367785122743037 0.9499114429440405 0.992765481118216 1.088341122316475 1.0 12.218552905807814 VDLTLLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 VDLTLLSPK 9 0 E7EVA0;P27816-4;B5MEG9 E7EVA0 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VDLTLLS(1)PK;VDLT(0.001)LLS(0.999)PK 114.24 0.0086507 7270400.0 54311.0 53948.0 56989.0 48125.0 47893.0 34953.0 42131.0 40167.0 33117.0 46364.0 True False 51292.612044159025 58085.63812983944 53322.389784931656 41570.29197974445 41876.25317114761 39767.45847825715 44090.17498099271 40283.87931999517 39741.32536629264 45025.35085186106 1.1391940556536255 1.2900651972918173 1.184274831313783 0.9232641432715498 0.9300594527053355 0.8832237334273524 0.9792300147988809 0.8946932907315721 0.8826433245805566 1.0 15.45844989766363 -5.735477986687957 4.982186434121512 0.9226407546773682 1.2185475782595556 0.8662922152248517 0.04987522687255066 0.055312951933662355 3.456302961259765 0.013060181334273049 0.022142703075792886 1.8387471530427295e-06 5.735477986687957 0.29590682358218745 VDLYQQAS(ph)PPDALR ddPTM_A459_Selumetinib_30min_R1 2 VDLYQQASPPDALR 14 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 VDLYQQAS(1)PPDALR;VDLYQQAS(1)PPDALR 133.28 0.00073942 25508000.0 2241.1800000000003 2727.8 2599.25 2563.3 2435.63 2226.3 2288.76 2258.29 1122.29 2197.29 True False 2293.3951334228586 2408.427907880184 2246.2861266582495 2115.667774100288 2215.327696545404 2203.905443318668 2116.1169905087518 2198.3928132402652 1904.4441611815253 2479.333574917071 0.9250046692484969 0.9714013201957875 0.9060039961477888 0.8533211486764355 0.8935174028043008 0.888910417547338 0.8535023330128266 0.8866869853580703 0.768127443781027 1.0 11.275736672465573 -5.5002657414303755 4.802598873285033 0.8732968786514601 0.9472219447182287 0.20521684142627838 0.05462721732919912 0.25826677972623285 15.548539383965196 0.013775739969694528 0.027741771200591507 3.1603432788330863e-06 5.5002657414303755 0.07392506606676863 VDLYQQAS(ph)PPDALR ddPTM_A459_Selumetinib_30min_R2 3 VDLYQQASPPDALR 14 0 P48634;P48634-4;P48634-2;P48634-3 P48634;P48634-2 PRRC2A Protein PRRC2A 1 VDLYQQAS(1)PPDALR;VDLYQQAS(1)PPDALR;VDLYQQAS(1)PPDALR 106.19 0.0056002 10331900.0 44566.0 37714.0 45960.0 47220.0 48401.0 35081.0 32719.8 32256.6 29698.7 40772.0 True False 42089.20013183318 40606.54253037675 43002.9836374644 40788.554540956524 42320.43366957 39913.08931638885 34241.335533053716 32350.461365632407 35639.26985101051 39594.80642162193 1.0629980024059196 1.0255522428366346 1.0860763702075162 1.0301491086134649 1.0688379990780725 1.0080385010947575 0.8647936087485254 0.8170379978917253 0.9000996108304907 1.0 15.273023586592865 -7.141771682650087 3.745685644399387 0.8803172848709692 1.0524871245964689 0.7166829094955425 0.046894055584508536 0.11573244152321409 2.893921712876469 0.018067888611947275 0.013693786482586233 7.214866795658933e-08 7.141771682650087 0.1721698397254997 VDNDENEHQLS(ph)LR ddPTM_A459_Selumetinib_30min_R1 2 VDNDENEHQLSLR 13 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 1 VDNDENEHQLS(1)LR;VDNDENEHQLS(1)LR 109.1 0.0060494 5315800.0 2741.5 4427.5 3754.6 4231.0 3996.1 3312.1 4253.700000000001 4159.2 2164.4 3434.1000000000004 True False 2805.3716159696064 3909.1262417110897 3244.7459425415254 3492.1352757064406 3634.653460568759 3278.783281146185 3932.839984326484 4048.8845050143714 3672.82871847855 3874.900185966673 0.7239855173894626 1.0088327580329346 0.8373753611235427 0.9012194142067317 0.9379992480146997 0.8461594167046204 1.0149525911840633 1.0449003356725934 0.947851181245921 1.0 11.91994343296753 -7.269888888646104 24.79184983566273 1.0056677308585469 0.8841882692602249 0.41512665139973737 0.07281811532683141 566.342002115643 1661706.211869932 0.028228152402044047 0.01938055213784023 5.371692099599851e-08 7.269888888646104 -0.12147946159832201 VDNDENEHQLS(ph)LR ddPTM_A459_Selumetinib_30min_R2 2 VDNDENEHQLSLR 13 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 1 VDNDENEHQLS(1)LR;VDNDENEHQLS(1)LR 104.16 0.0079013 5871200.0 36140.0 34162.0 40430.0 40128.0 47914.0 31647.9 33795.0 39739.0 39194.0 40270.0 True False 34131.483479882634 36782.11555185689 37828.77781685568 34662.49717533893 41894.61496340523 36007.11095396778 35366.534463522075 39854.63391085438 47033.89517185962 39107.30046597458 0.8727650099392269 0.9405434564285325 0.9673073151589362 0.886343387611148 1.0712735081230105 0.9207260671264147 0.9043460950287998 1.019109819291414 1.2026883628232432 1.0 15.25515033140225 -8.003874847724083 6.334001358709323 1.105432956598012 0.9424005666288395 0.4755865344774727 0.06910136660702154 0.11480168947556231 21.140249557926378 0.040401263151520775 0.01723075680035806 9.911175178100274e-09 8.003874847724083 -0.16303238996917258 VDNDENEHQLSLR ddPTM_A459_Selumetinib_30min_R1 6 VDNDENEHQLSLR 13 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 0 ;;;;; 265.77 1.8456e-30 158826500.0 18437.1 21390.500000000004 18954.1 19569.3 18670.9 18605.3 20796.1 19259.399999999998 11648.5 17356.5 False True 18866.648557648467 18886.09031582635 16380.237327418732 16151.889116256689 16982.12039161513 18418.147574260784 19227.43343396384 18748.578148652094 19766.65372722113 19584.37584162678 0.9633520470714835 0.9643447648550423 0.836393125820348 0.8247334123319718 0.8671259441171196 0.940451088316679 0.9817741238960368 0.9573232407438693 1.0093073114542113 1.0 14.257415529561943 -7.008578154863773 3.3351461299441314 0.982886122308103 0.8887893331622282 0.49838784650300216 0.04513566539667264 0.24516693154376926 5.696267275185011 0.0201258209742158 0.01629299374103479 9.80441859869131e-08 7.008578154863773 -0.09409678914587483 VDNDENEHQLSLR ddPTM_A459_Selumetinib_30min_R2 3 VDNDENEHQLSLR 13 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 0 ;; 231.07 5.2266e-13 812240000.0 771995.0 655350.0 772599.0 823971.0 860780.0 667809.0 688031.0 642121.0 629581.0 748372.0 False True 729090.6084408417 705613.237717622 722890.8214821867 711744.7283707429 752641.1209291639 759793.6279834762 720025.8048075621 643989.465801146 755514.7919629166 726764.5558560283 1.0032005586486996 0.9708966019765602 0.9946698908984645 0.9793332966443387 1.0356051555687888 1.0454467294274472 0.9907277384482119 0.886104668440545 1.0395592160834322 1.0 19.471128535811758 -11.889462411361484 5.703463275890609 1.9446390395358797 0.9923357544062885 0.0005016450225620028 0.04354640599103585 0.4401414665360784 0.02828962827958071 0.035479091337862735 0.010472613431123207 1.2898451905087403e-12 11.889462411361484 -0.9523032851295912 VDNLTYRT(ph)SPDTLR ddPTM_A459_Selumetinib_30min_R1 1 VDNLTYRTSPDTLR 14 1 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 1 VDNLTYRT(0.497)S(0.497)PDT(0.005)LR 189.04 0.00098958 132120000.0 2481.2 1625.5 4610.0 4962.5 3770.2 2302.9 1906.9 1770.2 1192.3 913.1 True False 2539.0071324252376 1435.185704325551 3983.987320917392 4095.892532662069 3429.186075682871 2279.734916865903 1763.0609977460012 1723.2485455800258 2023.2460178534361 1030.3052793471845 2.4643250726949466 1.3929713193694437 3.8668027824158107 3.975416427311022 3.328320396315595 2.2126790598514394 1.7112025271413738 1.672561113801047 1.9637344954064415 1.0 10.008856155803477 -6.983886130002768 3.497502842490123 1.6588606022961834 3.0136723393338842 0.45925971355085815 0.7236955591619096 0.2578639366234695 6.7161097796300275 0.3111014811344662 0.25716871356085974 1.0378004866188977e-07 6.983886130002768 1.3548117370377009 VDS(ph)EGDFSENDDAAGDFR ddPTM_A459_Selumetinib_30min_R2 1 VDSEGDFSENDDAAGDFR 18 0 O43823;M0QYL4 O43823 AKAP8 A-kinase anchor protein 8 1 VDS(0.506)EGDFS(0.494)ENDDAAGDFR 111.73 0.0012863 15926000.0 14866.0 12849.0 15033.0 17028.0 17024.0 12928.0 18638.0 16037.0 15387.0 13264.0 True False 14039.80723331311 13834.476983953198 14065.793146692842 14708.757025061588 14885.292923509 14708.714651300572 19504.70393049637 16083.665014931725 18464.829948701412 12881.033855989235 1.089959656210754 1.074019146182171 1.0919770341378876 1.1418925832744804 1.1555976864844473 1.1418892936502554 1.5142188234702416 1.2486315302597684 1.433489745865073 1.0 13.652960771064883 -7.034421011491329 23.143437286678132 1.3209830039876445 1.1132856510710105 0.3270169237103332 0.12783245128393247 254.62706306730212 171200.83160131992 0.04522240796438834 0.03505758009507036 9.238021922168807e-08 7.034421011491329 -0.20769735291663394 VDS(ph)LVSLSEEDLESDQR ddPTM_A459_Selumetinib_30min_R1 2 VDSLVSLSEEDLESDQR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 VDS(0.967)LVS(0.031)LS(0.002)EEDLESDQR;VDS(0.812)LVS(0.173)LS(0.015)EEDLESDQR 225.6 4.781e-13 14804100.0 1194.87 1356.6 1241.8 1067.5900000000001 1151.26 1111.18 1568.03 1273.53 623.31 1333.08 True False 1222.708146187709 1197.7686413337697 1073.1703807191361 881.155447646287 1047.128736271461 1100.0025380707168 1449.752234671804 1239.7518473915545 1057.7115452388034 1504.1938032988114 0.8128660971120989 0.7962861159958058 0.7134522016814534 0.5857991474993754 0.6961395094003366 0.7312904332263087 0.9638068123219143 0.8241968851837339 0.7031750449437842 1.0 10.554774743330086 -7.117122543643364 8.242324320901634 0.8578799136981735 0.7168658305845084 0.3725064500326435 0.09468057708566156 0.37077422656615744 23.982661626558148 0.037773325725832994 0.02925473959798755 7.636202846038013e-08 7.117122543643364 -0.14101408311366515 VDS(ph)LVSLSEEDLESDQR ddPTM_A459_Selumetinib_30min_R2 3 VDSLVSLSEEDLESDQR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 VDS(0.765)LVS(0.235)LSEEDLESDQR;VDS(0.986)LVS(0.014)LSEEDLESDQR;VDS(0.987)LVS(0.013)LSEEDLESDQR 254.68 4.3521e-31 6906600.0 24209.7 20179.7 23300.5 26624.4 25927.6 20375.6 27144.1 28041.2 22359.9 22648.8 True False 22864.221793107772 21727.41810203755 21801.37119766623 22998.110790348233 22670.3430923151 23182.153948719042 28406.35443501374 28122.79524952945 26832.504787805858 21994.870295350505 1.0395251931965719 0.9878402468520358 0.9912025351781603 1.045612476069468 1.0307104696638008 1.0539800252252234 1.2914990656261591 1.2786070057196166 1.2199437608630945 1.0 14.424879473190924 -7.140371238429278 5.197063808914251 1.219853798569839 1.0196054206288538 0.5385535749517598 0.07761161983578173 0.15286708620000367 5.870483404981464 0.028847404098274104 0.022216632449971924 7.238169709639357e-08 7.140371238429278 -0.20024837794098516 VDS(ph)PMLNR ddPTM_A459_Selumetinib_30min_R1 2 VDSPMLNR 8 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 VDS(1)PMLNR;VDS(1)PMLNR 110.38 0.012048 17610900.0 8441.7 8955.7 8957.3 9199.400000000001 7890.6 7235.0 8020.3 7335.2 4320.2 7655.1 True False 8638.375185311192 7907.162480608027 7740.94785892697 7592.89748412523 7176.896623198579 7162.2224688544 7415.322313819423 7140.64666791244 7331.063865076255 8637.706651988425 1.0000773970857892 0.915423827085836 0.8961809159315433 0.8790409063472101 0.8308798749893221 0.8291810265639938 0.8584827677740589 0.8266831643638468 0.8487280432692887 1.0 13.07643260619569 -4.457074765471929 0.9412120269555673 0.8564448354246207 1.159167082234449 0.39118230348854066 0.04866400390936873 3.0873738090334863 1.4360259633932486 0.01524441835390068 1.1024269677710399 3.490802147986294e-05 4.457074765471929 0.3027222468098284 VDS(ph)PMLNR ddPTM_A459_Selumetinib_30min_R2 2 VDSPMLNR 8 0 Q8IWQ3-6;Q8IWQ3-3;Q8IWQ3-2;Q8IWQ3-4;Q8IWQ3;Q8IWQ3-5 Q8IWQ3-6 BRSK2 Serine/threonine-protein kinase BRSK2 1 VDS(1)PMLNR;VDS(1)PMLNR 110.38 0.012048 16808000.0 96345.0 75008.0 89817.0 94037.0 94799.0 67190.0 76795.0 80326.0 49056.0 75684.0 True False 90990.53059959317 80760.8724112663 84038.27200535555 81228.99837712687 82889.50210618712 76444.81260990753 80366.1196664056 80559.73536131493 58868.57073916273 73498.80626935227 1.2379865091432738 1.0988052256971443 1.1433964205810245 1.1051743899002338 1.1277666442965157 1.0400823699062403 1.0934343528231818 1.0960686227485976 0.8009459435766361 1.0 16.16543319816143 -8.170346276013051 6.788586973992894 0.9020670356603347 1.1155767023116119 0.6404776217504895 0.06519790879913276 0.1370223844615305 8.49415478431066 0.04287578513208551 0.015905914506372857 6.755441290106077e-09 8.170346276013051 0.21350966665127713 VDS(ph)PSHGLVTSSLCIPSPAR ddPTM_A459_Selumetinib_30min_R1 2 VDSPSHGLVTSSLCIPSPAR 20 0 Q9UER7-3;Q9UER7 Q9UER7-3 DAXX Death domain-associated protein 6 1 VDS(0.891)PS(0.108)HGLVTSSLCIPSPAR;VDS(0.857)PS(0.143)HGLVTSSLCIPSPAR 177.12 4.1193000000000004e-13 57836000.0 619.55 665.38 833.1500000000001 674.88 547.81 771.9300000000001 698.4200000000001 631.29 299.93 531.16 True False 633.984309565555 587.4770002732305 720.012806165363 557.024877066595 498.26068222371066 764.1650850563619 645.7376170988324 614.5461384810837 508.95930397951963 599.3395599365356 1.0578048771429138 0.9802072807198623 1.2013437027944653 0.9293978143634948 0.8313495646382357 1.275011923353232 1.0774153088896885 1.025372225631424 0.8492002497439242 1.0 9.227229793185224 -8.093367402467708 6.844106333519691 0.9259824009098157 1.0492103149407046 0.13840506183932322 0.12368406543292562 0.5269246554119702 32.79289210547573 0.08603342805616476 0.03212813755931535 8.065524180119895e-09 8.093367402467708 0.12322791403088895 VDS(ph)PSHGLVTSSLCIPSPAR ddPTM_A459_Selumetinib_30min_R2 3 VDSPSHGLVTSSLCIPSPAR 20 0 Q9UER7-3;Q9UER7 Q9UER7-3 DAXX Death domain-associated protein 6 1 VDS(0.654)PS(0.346)HGLVTSSLCIPSPAR;VDS(0.965)PS(0.035)HGLVTSSLCIPSPAR;VDS(0.813)PS(0.187)HGLVTSSLCIPSPAR 255.93 4.4718e-39 32549300.0 41635.4 38694.9 40150.9 50330.3 48579.6 28650.5 36488.2 37540.4 28566.0 37694.7 True False 39321.47114771186 41662.67440628615 37567.63480699458 43475.22631538976 42476.59634086572 32596.84631165586 38184.97359999666 37649.636348852226 34279.9982007282 36606.3560684075 1.0741705914194393 1.1381267867369738 1.0262598860370236 1.187641464071053 1.1603612296588142 0.8904695744843072 1.0431241374759932 1.0284999763017961 0.936449346027997 1.0 15.159806549157933 -6.746972540231594 24.999999971833798 0.9854533114503768 1.1173171213909459 0.5797186195585233 0.058479294239715714 181.6101589901683 313838.0378800312 0.0193586506321138 0.019275406192573685 1.7907190748534242e-07 6.746972540231594 0.131863809940569 VDS(ph)PTVTTTLK ddPTM_A459_Selumetinib_30min_R1 3 VDSPTVTTTLK 11 0 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9 Q07866-6 KLC1 Kinesin light chain 1 1 VDS(0.795)PT(0.138)VT(0.012)T(0.018)T(0.038)LK;VDS(1)PTVTTTLK;VDS(0.988)PT(0.012)VTTTLK 179.67 5.2145e-05 69625800.0 17833.8 20742.8 15839.9 15997.7 14869.9 16401.3 18466.0 16826.7 9704.6 16785.3 True False 18249.292841465907 18314.22333293389 13688.928582342609 13204.002009021255 13524.920170494075 16236.317813188902 17073.094752938116 16380.401255175353 16467.997404059766 18939.85675766762 0.9635391162120512 0.966967362386178 0.7227577672571772 0.6971542698534792 0.7140983347204376 0.857256631923353 0.901437374705922 0.8648640517592037 0.8694890154009667 1.0 14.209137799279505 -8.683027133827474 0.7394384708735932 0.9974532177609965 0.8193792569716787 0.23203380610861524 0.09193688788077242 1.5061693429838483 1.7593678981025176 0.10428111098183923 0.03870656910469573 2.074783885168467e-09 8.683027133827474 -0.1780739607893178 VDS(ph)PTVTTTLK ddPTM_A459_Selumetinib_30min_R2 3 VDSPTVTTTLK 11 0 Q07866-6;Q07866-4;Q07866-7;G3V5R9;Q07866-9;H0YG16;G3V3H3;Q07866-3;G3V2E7;Q07866-10;Q07866-5;Q07866;Q07866-2;Q07866-8;G5E9S8;F8W6L3;E7EVH7;H0YJT3;H0YJL0;H0YJU9 Q07866-6 KLC1 Kinesin light chain 1 1 VDS(0.983)PT(0.017)VTTTLK;VDS(0.997)PT(0.003)VTTTLK;VDS(0.996)PT(0.003)VTTTLK 152.4 0.00057895 85980800.0 200678.0 176325.0 174771.0 191400.0 179533.0 152811.0 194365.0 178078.0 138917.0 160551.0 True False 189525.12013768367 189848.5605257649 163526.42413627717 165330.9898165835 156978.4594946159 173859.32816985543 203403.35762694108 178596.17749759994 166704.28166528605 155915.475468405 1.215563237506141 1.2176376973191232 1.0488145813942278 1.0603885811840819 1.0068176941577958 1.1150870537228141 1.3045745267804356 1.145467933577838 1.0691965064049547 1.0 17.250404604996426 -8.89906271605213 0.011139222040462651 5.178899577186787e-06 2.188061175538807 0.13622282714308254 0.08904323514522772 5213.711972158943 27.042020476209014 2719.1780449961066 2588.9019831453065 1.2616453284356922e-09 8.89906271605213 2.1880559966392297 VDS(ph)TTCLFPVEEK ddPTM_A459_Selumetinib_30min_R1 5 VDSTTCLFPVEEK 13 0 A0A6I8PRN4;A0A6I8PTT9;Q06210-2;Q06210 A0A6I8PRN4 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 VDS(0.436)T(0.436)T(0.127)CLFPVEEK;VDS(0.939)T(0.061)TCLFPVEEK;VDS(0.333)T(0.333)T(0.333)CLFPVEEK;VDS(0.755)T(0.111)T(0.134)CLFPVEEK;VDS(0.333)T(0.333)T(0.333)CLFPVEEK 283.82 6.9225e-49 623045000.0 11370.8 15320.7 15169.0 16245.0 12840.1 12814.63 13488.34 13968.6 7313.84 11209.95 True False 11635.717516274743 13526.945321599811 13109.133117352692 13408.115706417193 11678.71522210377 12685.7264569531 12470.903654275173 13598.107351592565 12411.052298261495 12648.856276659708 0.9199027375894484 1.0694204302534764 1.0363888110217767 1.0600259354008559 0.9233020730620451 1.0029149023031771 0.9859313270312904 1.0750463958298317 0.9811995667278613 1.0 13.626719320311855 VDS(ph)TTCLFPVEEK ddPTM_A459_Selumetinib_30min_R2 5 VDSTTCLFPVEEK 13 0 A0A6I8PRN4;A0A6I8PTT9;Q06210-2;Q06210 A0A6I8PRN4 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 VDS(0.968)T(0.028)T(0.004)CLFPVEEK;VDS(0.81)T(0.19)T(0.001)CLFPVEEK;VDS(0.977)T(0.02)T(0.003)CLFPVEEK;VDS(0.333)T(0.333)T(0.333)CLFPVEEK;VDS(0.48)T(0.48)T(0.04)CLFPVEEK 238.88 1.0395e-17 154256500.0 630198.0 586130.8 651327.9 647247.0 587701.0 502872.1 443224.2 508085.4 331177.2 575077.8 True False 595174.1180424758 631085.1476524314 609422.1720261977 559090.8420366483 513868.7462663985 572138.1671565815 463835.00353209075 509563.8443959342 397421.8938641122 558473.8096824355 1.0657153616226143 1.1300174452429288 1.0912278453536306 1.001104854593922 0.9201304293187881 1.0244673201092742 0.830540296591242 0.9124220967240829 0.7116213633905194 1.0 19.09113009976987 -6.36553961415087 0.783117387620654 0.8581227052945546 1.114969487959942 0.5540447293175228 0.08077105008772681 0.48129220779179416 0.6475046717427808 0.04546600993070581 0.06907968506365425 4.309832440955468e-07 6.36553961415087 0.2568467826653875 VDSEGDFS(ph)ENDDAAGDFR ddPTM_A459_Selumetinib_30min_R2 1 VDSEGDFSENDDAAGDFR 18 0 O43823;M0QYL4 O43823 AKAP8 A-kinase anchor protein 8 1 VDSEGDFS(1)ENDDAAGDFR 332.61 2.3296999999999985e-144 18742000.0 32972.0 33784.0 38034.0 40882.0 37583.0 36520.0 34435.0 44228.0 36382.0 30885.0 True False 31139.54823737385 36375.12416731846 35586.933848288114 35313.801074616356 32861.48754371703 41550.298504447426 36036.29573165802 44356.69615766047 43659.416598014905 29993.269801132938 1.038217855000178 1.212776213080458 1.1864973070373237 1.1773908383034133 1.0956287114276466 1.3853207329491612 1.2014793975646103 1.4788883123368224 1.4556404449229392 1.0 14.872351189809905 -6.760906000801276 24.999980635515506 1.3277721565992386 1.1504553880348334 0.25049828934567875 0.13689206447553903 18.635946061904296 873494.7528794729 0.04497521212406392 0.04240771014437048 1.7341793049062547e-07 6.760906000801276 -0.17731676856440526 VDSLVS(ph)LSEEDLESDQR ddPTM_A459_Selumetinib_30min_R1 2 VDSLVSLSEEDLESDQR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 VDS(0.333)LVS(0.664)LS(0.004)EEDLESDQR;VDSLVS(0.972)LS(0.027)EEDLESDQR 239.19 1.6195e-22 9842000.0 2674.73 3269.77 2813.04 2865.5 3464.95 3267.62 3331.4 2946.23 1533.0 2690.35 True False 2737.046004881412 2886.9438083251675 2431.044618922661 2365.0942170968583 3151.5458842866065 3234.7507095615774 3080.1098158744726 2868.0864096962164 2601.38903410997 3035.682628728177 0.9016245568556417 0.9510031717428495 0.8008230491278879 0.7790979843264225 1.038167117491782 1.065576051643054 1.014634990735151 0.9447912580037472 0.8569370887100416 1.0 11.567805253974889 -6.270479907711938 24.962190439592888 0.9892660917774287 0.8606766061796374 0.449263073547739 0.06966738617278787 672.4531823258551 1856735.869298937 0.023859185922511215 0.02743332834872517 5.36438688774596e-07 6.270479907711938 -0.12858948559779138 VDSLVS(ph)LSEEDLESDQR ddPTM_A459_Selumetinib_30min_R2 1 VDSLVSLSEEDLESDQR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 VDS(0.403)LVS(0.596)LS(0.001)EEDLESDQR 137.27 0.00051189 1962800.0 8393.6 5097.3 4720.4 4535.1 6463.7 3711.8 5444.3 4700.6 6185.3 3213.2 True False 7927.117314243024 5488.246519597219 4416.694603182923 3917.4115565161387 5651.672219788835 4223.066757634396 5697.4707376757915 4714.277967773782 7422.532831721771 3120.426567103785 2.540395405491165 1.7588129063684774 1.4154137289256146 1.2554089872885785 1.8111857780503446 1.3533620057446258 1.8258627835500973 1.5107799739537935 2.378691717975909 1.0 11.607527545858531 -4.778384464102073 3.541661398475212 1.5856320184586512 2.6564572054205016 0.3967463840039669 0.35769349723784777 0.28589675409449744 5.957057206048493 0.08600034528278283 0.8275651276301396 1.6657719162069458e-05 4.778384464102073 1.0708251869618504 VDSLVSLS(ph)EEDLESDQR ddPTM_A459_Selumetinib_30min_R1 3 VDSLVSLSEEDLESDQR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 VDSLVS(0.363)LS(0.637)EEDLESDQR;VDSLVS(0.079)LS(0.921)EEDLESDQR;VDSLVS(0.206)LS(0.794)EEDLES(0.001)DQR 303.44 2.0142e-89 41189700.0 5910.799999999999 7699.0 5783.91 6951.48 6862.25 6435.6 7211.08 6959.18 3859.0 6983.97 True False 6048.510139585323 6797.597500832005 4998.486790743455 5737.534513440748 6241.560699128635 6370.863707057272 6667.142429926182 6774.5999397975365 6548.441149791506 7880.430579128642 0.7675354891907594 0.8625921429769934 0.6342910759193756 0.7280737335135767 0.7920329525723426 0.8084410671582508 0.846037835493931 0.8596738302270052 0.8309750443249997 1.0 12.944058743963353 -8.580551940352867 0.41184351894959786 1.0099457605583242 0.746188468862121 0.605492942037586 0.057118315019243034 1.0253662402212091 0.4422598456762506 0.09397001933650398 0.04677334414355362 2.6269273348365363e-09 8.580551940352867 -0.2637572916962032 VDSLVSLS(ph)EEDLESDQR ddPTM_A459_Selumetinib_30min_R2 1 VDSLVSLSEEDLESDQR 17 0 Q12802-4;Q12802;Q12802-2;A0A087WTD7;A8MYJ1;H0YMW2;A0A087WY36;H0YLH1 Q12802-4 AKAP13 A-kinase anchor protein 13 1 VDSLVS(0.003)LS(0.997)EEDLESDQR 157.83 3.9189e-05 1976500.0 6131.1 3151.9 5587.3 5693.7 5142.0 4385.7 4251.7 5399.5 4859.2 4847.1 True False 5790.358006737927 3393.6405950441344 5227.819200992275 4918.2082378196565 4496.0159899367545 4989.790365579273 4449.412474583723 5415.211651064653 5831.175777391952 4707.151628721759 1.2301192873003575 0.7209541698926931 1.1106120247101334 1.0448374358306385 0.9551457748892743 1.0600445363036384 0.9452451982712047 1.1504221827107723 1.2387907246946759 1.0 12.200638611129152 -7.775524611143365 24.534877534274855 1.1459549460816796 1.003556511836557 0.13779849976945036 0.13536461015183243 317.2092897878384 552532.477602389 0.06851577930935154 0.03318629545199904 1.6767773113404108e-08 7.775524611143365 -0.14239843424512255 VDSSTNSSPS(ph)PQQSESLS(ph)PAHTSDFR ddPTM_A459_Selumetinib_30min_R2 2 VDSSTNSSPSPQQSESLSPAHTSDFR 26 0 F2Z3H6;Q9BQE9-2;Q9BQE9-3;Q9BQE9 F2Z3H6 BCL7B B-cell CLL/lymphoma 7 protein family member B 2 VDS(0.001)S(0.005)T(0.02)NS(0.05)S(0.042)PS(0.844)PQQS(0.038)ES(0.362)LS(0.637)PAHTSDFR;VDS(0.007)S(0.026)T(0.029)NS(0.067)S(0.061)PS(0.81)PQQS(0.01)ES(0.338)LS(0.649)PAHT(0.002)S(0.001)DFR 96.307 1.5042e-05 5274900.0 15200.900000000001 14082.1 29006.0 35216.0 42279.0 23862.2 17435.6 20206.6 26359.0 29388.0 True False 14356.094832024035 15162.151788911773 27139.78553934492 30419.520049011564 36967.534040944374 27149.001450515494 18246.38994798597 20265.39786061729 31631.53653199589 28539.492080806078 0.5030255896417676 0.5312691531433704 0.9509554501706596 1.0658746120247136 1.2953115611264323 0.951278368011821 0.6393382859205605 0.7100826392858813 1.1083426587423164 1.0 14.800672038854268 -5.257187884332175 6.011275466295748 0.9588275761263972 0.5126632014491846 0.506500297067598 0.17688427808325133 0.13397575990791669 22.263643275551203 0.051951721555129324 0.1263449401374502 5.531107708532324e-06 5.257187884332175 -0.4461643746772126 VDST(ph)TCLFPVEEK ddPTM_A459_Selumetinib_30min_R1 1 VDSTTCLFPVEEK 13 0 A0A6I8PRN4;A0A6I8PTT9;Q06210-2;Q06210 A0A6I8PRN4 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 VDS(0.052)T(0.896)T(0.052)CLFPVEEK 300.33 1.3459999999999992e-73 168730000.0 3837.0 4458.9 4260.4 4974.4 3557.6 4186.8 3642.3 3911.3 1880.2 3435.7 True False 3926.394634497678 3936.8499151136257 3681.8610807020505 4105.714421052734 3235.815708145293 4144.684593310243 3367.558378567445 3807.5596183070616 3190.562075625286 3876.705561551993 1.0128173450773477 1.0155142949617135 0.9497396751555363 1.0590730598093345 0.83468183403897 1.0691254539462542 0.8686649850238518 0.9821637361550745 0.8230086151675606 1.0 11.920615450233582 -6.139000430484449 0.6973342616898811 0.9253353069689417 1.0175524536339458 0.1307741100187495 0.07943004689300179 1.734540587652188 1.738808331562682 0.044562262619347474 0.09576651525901976 7.261052376996267e-07 6.139000430484449 0.09221714666500402 VDST(ph)TCLFPVEEK ddPTM_A459_Selumetinib_30min_R2 1 VDSTTCLFPVEEK 13 0 A0A6I8PRN4;A0A6I8PTT9;Q06210-2;Q06210 A0A6I8PRN4 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 VDS(0.059)T(0.909)T(0.032)CLFPVEEK 106.58 0.016163 4298900.0 31107.0 29625.0 36352.0 30545.0 26814.0 32322.0 25984.0 25854.0 20497.0 31972.0 True False 29378.197471187315 31897.1422406112 34013.15189706497 26384.718306935985 23445.385599798556 36774.06211009723 27192.30748631922 25929.230859639905 24596.97273403086 31048.88528676778 0.9461916973781835 1.0273200453416897 1.0954709511442744 0.8497798894629064 0.7551119914050622 1.184392346792861 0.875790136591727 0.8351098797962406 0.7922014754105663 1.0 14.922253853466371 -5.768355439581953 24.999069865175525 0.8969817269914055 1.023426816947286 0.18533943391133956 0.11916357883326177 273.00100801072966 986803.8428914427 0.0344810487931019 0.052416989048806505 1.7046866514279133e-06 5.768355439581953 0.12644508995588044 VDSTT(ph)CLFPVEEK ddPTM_A459_Selumetinib_30min_R1 1 VDSTTCLFPVEEK 13 0 A0A6I8PRN4;A0A6I8PTT9;Q06210-2;Q06210 A0A6I8PRN4 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 VDS(0.182)T(0.182)T(0.637)CLFPVEEK 266.89 1.1103e-37 183810000.0 8145.2 10802.0 10277.0 11975.0 9492.3 9310.3 9268.8 9531.2 4983.5 7985.4 True False 8334.967312199757 9537.296818286442 8881.439847520176 9883.791048590081 8633.723141001674 9216.646835076037 8569.646953646303 9278.401614299148 8456.63551956101 9010.403874382884 0.9250381479454618 1.058476062921169 0.985687209068468 1.096930968509668 0.9581949112789343 1.0228894246660256 0.9510835555341 1.0297431439980396 0.9385412282798699 1.0 13.137376058238154 VDSTT(ph)CLFPVEEK ddPTM_A459_Selumetinib_30min_R2 1 VDSTTCLFPVEEK 13 0 A0A6I8PRN4;A0A6I8PTT9;Q06210-2;Q06210 A0A6I8PRN4 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 VDS(0.187)T(0.187)T(0.627)CLFPVEEK 214.48 4.4031e-06 78467000.0 321580.0 288880.0 352400.0 326990.0 307380.0 254950.0 221050.0 261480.0 171630.0 299280.0 True False 303707.87098673667 311036.16710439755 329726.9676641088 282453.39791078767 268764.17638793425 290067.0482943282 231329.2630022651 262240.863509656 205960.79574287523 290639.0087771753 1.0449659605726942 1.070180387736115 1.134489719915406 0.9718358148108629 0.9247353874441134 0.9980320587891711 0.795933291871425 0.9022906615770516 0.7086481495014303 1.0 18.14886882500732 -6.475363902729574 0.9495362978466572 0.847687015415438 1.0830314184257566 0.521873831465022 0.08395633047544067 0.41498684791878937 0.811130040598417 0.0421737861534042 0.052601288588477714 3.346848834794061e-07 6.475363902729574 0.23534440301031856 VDT(ph)TPNQGK ddPTM_A459_Selumetinib_30min_R2 2 VDTTPNQGK 9 0 Q9P2E9;A2A2S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 VDT(0.5)T(0.5)PNQGK;VDT(0.864)T(0.136)PNQGK 108.43 0.028095 10609600.0 145308.0 86136.0 109084.0 148687.0 129165.0 98059.0 182552.0 240410.0 165685.0 162439.0 True False 137232.36307401178 92742.35422910667 102065.65420167882 128435.5741006184 112938.13795024918 111565.73715902564 191041.02971992537 241109.55329798168 198826.62962569634 157748.96400279255 0.869941453761829 0.5879110193551883 0.6470131505895151 0.8141769736018347 0.7159358456911951 0.7072359420189324 1.2110445918145203 1.5284382678653499 1.260398956548308 1.0 17.26727100495087 -7.307428333631799 4.420766081743017 1.3061597287325903 0.7160970579121018 0.7648419795830191 0.14225731724240454 0.09200705323508122 4.021845551660752 0.05879327765504264 0.039677229225023466 4.9268763892677405e-08 7.307428333631799 -0.5900626708204886 VDTFPQPLAAPQCHTLLAPEMEDNEMSCS(ph)P ddPTM_A459_Selumetinib_30min_R1 1 VDTFPQPLAAPQCHTLLAPEMEDNEMSCSP 30 0 B7Z4K4;Q9UET6-2;Q9UET6 B7Z4K4 FTSJ1 Putative tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase 1 VDTFPQPLAAPQCHT(0.004)LLAPEMEDNEMS(0.188)CS(0.808)P 72.881 0.0010784 0.0 458.1 469.87 518.12 472.42 567.12 399.34 425.79 371.73 165.0 289.85 True False 468.7728386925689 414.8574019633634 447.76214982944026 389.9207154217057 515.8240961331683 395.323002171709 393.67231749450417 361.87051285078684 279.992948876807 327.0550708780876 1.4333146935590788 1.2684634451609063 1.3690726415807424 1.192217305711954 1.5771781025998703 1.2087352784665089 1.203688163089967 1.106451313777908 0.8561033715975517 1.0 8.35338977287802 -7.714553366724726 1.4068091184011269 0.9336218786549023 1.347173864375698 0.6856004306940158 0.11108728857468428 0.24369062091176527 0.8991133363228252 0.08487855429372235 0.03409564218506873 1.9295082209020337e-08 7.714553366724726 0.41355198572079577 VDVADQAQDKDRDDR ddPTM_A459_Selumetinib_30min_R2 2 VDVADQAQDKDRDDR 15 2 E7EX17;P23588;P23588-2;F8VP89;F8W0K0;F8VSC7 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 ; 85.45 0.013133 89053000.0 523220.0 438236.0 479530.0 621220.0 565080.0 438506.0 521010.0 532620.0 401379.0 465190.0 False True 494141.5270156121 471847.2920491654 448677.5618727875 536608.7643357257 494089.59852070466 498906.2211388615 545237.9973617299 534169.8360200127 481666.0154662912 451758.7559912263 1.0938172652157936 1.0444673972369654 0.9931795586082705 1.1878215025590944 1.0937023178147331 1.1043642530938589 1.2069229209855514 1.1824227620070455 1.0662018368840331 1.0 18.785193038122593 -5.758409800911914 24.999999919556505 1.1296549586100728 1.0438860119402824 0.22533891470646017 0.06322315862202318 103.03851531059603 850253.5341320737 0.017041094639646943 0.027968316367086 1.7441755695505523e-06 5.758409800911914 -0.0857689466697904 VDVEVPDVS(ph)LEGPEGK ddPTM_A459_Selumetinib_30min_R1 2 VDVEVPDVSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VDVEVPDVS(1)LEGPEGK;VDVEVPDVS(1)LEGPEGK 165.66 1.7746e-05 3114700.0 1991.08 2645.3 2762.3 2859.8 2262.27 2314.6 2261.87 2373.6 1216.97 1920.64 True False 2037.4682900327439 2335.5870462333933 2387.194832227791 2360.3896150946066 2057.6480779362087 2291.3172254886513 2091.2553248580157 2310.644417460597 2065.1092060279266 2167.17285261787 0.9401503380644293 1.0777114725353285 1.1015248872945884 1.0891561382578863 0.9494619109180151 1.057284019925231 0.9649693250503076 1.0662021788753115 0.9529047041786934 1.0 11.081598511314432 -6.24657972086178 24.942708444759962 1.003046093931507 1.0574903452929503 0.17759738849142848 0.05558266288896487 1400.4863018941458 2350786.548559214 0.016067197921603698 0.02063777447695629 5.667875201505819e-07 6.24657972086178 0.054444251361443374 VDVEVPDVSLEGPEGK ddPTM_A459_Selumetinib_30min_R2 2 VDVEVPDVSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 ; 201.48 1.7865e-20 0.0 29818.0 26413.0 29070.0 32830.0 31242.0 28006.0 33339.0 30871.0 24910.0 25560.0 False True 28160.834930911496 28438.79216881904 27199.66784902287 28358.497365091127 27317.10065297628 31863.572286844344 34889.329559975246 30960.82949903084 29892.69604355314 24822.01638714452 1.134510367396912 1.1457083794186709 1.095788006292259 1.1424735574575713 1.100519000024671 1.2836818649167718 1.405579990594344 1.2473132325811231 1.2042815368953974 1.0 14.59933269540349 -6.760108334801736 24.999740010097128 1.2547164524876444 1.1244982044638099 0.20253045363601352 0.09661795002834452 45.02052179382688 845583.0352739973 0.031924638595956886 0.030282301969796362 1.7373673882228184e-07 6.760108334801736 -0.13021824802383453 VDVGKDQEFTVK ddPTM_A459_Selumetinib_30min_R2 1 VDVGKDQEFTVK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 120.03 0.011641 4806300.0 32426.0 44127.0 40711.0 43097.0 33456.0 23672.0 32782.0 29811.0 20212.0 38821.0 False True 30623.89273156268 47511.39900933172 38091.69858278535 37227.114253528256 29252.958179565154 26932.603126979193 34306.427956300686 29897.74507452328 24254.96477046552 37700.13686092871 0.8123018981212337 1.2602447355720638 1.0103862148644465 0.9874530267848795 0.7759377184087106 0.7143900624639731 0.909981522954492 0.7930407569821957 0.6433654302088924 1.0 15.20228214039683 -6.141240604083854 3.369105023429558 0.7961180121394392 1.0458929265454038 0.3621513453030172 0.1368663858960501 0.24593754414716645 5.193781196329415 0.04045684877154333 0.054132726989266994 7.223694918070538e-07 6.141240604083854 0.24977491440596455 VDVS(ph)CEPLEGVEK ddPTM_A459_Selumetinib_30min_R1 2 VDVSCEPLEGVEK 13 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 VDVS(1)CEPLEGVEK;VDVS(1)CEPLEGVEK 139.3 0.00094237 21661000.0 8017.9 10703.2 11161.5 12808.8 9596.7 9085.6 10936.4 9515.8 5389.0 8874.3 True False 8204.701469882444 9450.06436821732 9645.829605730905 10571.983530954541 8728.680179435 8994.207113064758 10111.45854305385 9263.410072325389 9144.739403012805 10013.402848002108 0.8193719552109562 0.9437415543610944 0.9632918751147077 1.0557833027824186 0.8716996920958354 0.8982168449219337 1.009792444840198 0.925101108278455 0.9132499253075971 1.0 13.289644707138514 VDVS(ph)CEPLEGVEK ddPTM_A459_Selumetinib_30min_R2 2 VDVSCEPLEGVEK 13 0 A6NNK5;Q12888;Q12888-3;Q12888-2;C9JXV0;H7C3N7 A6NNK5 TP53BP1 Tumor suppressor p53-binding protein 1 1 VDVS(1)CEPLEGVEK;VDVS(1)CEPLEGVEK 164.2 0.00036279 14094700.0 73547.0 68549.0 77815.0 88847.0 77542.0 70029.0 76630.0 79098.0 59923.0 82551.0 True False 69459.55217196823 73806.48788022468 72808.467618566 76745.88533037604 67800.48072572461 79674.85909003147 80193.44683946432 79328.16208462119 71909.27438851203 80167.53813674375 0.866429901508131 0.9206530423116042 0.9082038604500341 0.9573187241881955 0.8457348485627145 0.9938543822329694 1.0003231819676983 0.9895297264749378 0.8969874348125123 1.0 16.29073055077199 -6.7843662594645755 24.999791656567055 0.9769960857725976 0.9045109110161985 0.47720457574732866 0.03985434060242658 221.20385401764224 241202.11303351773 0.01383614747597673 0.012209994356779308 1.6429855374711832e-07 6.7843662594645755 -0.07248517475639904 VEAAGPGGESEPTGS(ph)GGTLAHTPR ddPTM_A459_Selumetinib_30min_R2 1 VEAAGPGGESEPTGSGGTLAHTPR 24 0 Q9UMN6;A0A669KBI7;A0A669KAX8 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 VEAAGPGGESEPT(0.035)GS(0.624)GGT(0.02)LAHT(0.32)PR 115.92 9.9883e-08 3642800.0 21927.0 17793.0 26301.0 26732.0 29147.0 22504.0 21995.0 22428.0 20072.0 25649.0 True False 20708.385120735675 19157.665886487597 24608.822294363603 23091.055484727865 25485.293282513907 25603.72172902753 23017.811082265664 22493.261766844727 24086.960858538692 24908.44672589475 0.8313800273706868 0.7691232655856995 0.9879709708586661 0.9270371508441941 1.0231586723558908 1.0279132219999079 0.9240966060856943 0.9030375123094607 0.9670197874481653 1.0 14.604347438433784 -5.263629984030167 24.977298389197117 0.9673551791057007 0.8002516380158564 0.7207804643200013 0.04224178158863333 96.26757309878249 1097658.0539253987 0.011686000532213862 0.026371228611614155 5.449667631120203e-06 5.263629984030167 -0.16710354108984427 VEAAGPGGESEPTGSGGTLAHT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VEAAGPGGESEPTGSGGTLAHTPR 24 0 Q9UMN6;A0A669KBI7;A0A669KAX8 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 VEAAGPGGESEPTGSGGT(0.001)LAHT(0.999)PR 151.06 1.2301e-09 4367200.0 17172.0 15268.0 17278.0 21163.0 22412.0 17594.0 17297.0 17870.0 16893.0 18055.0 True False 16217.648984962498 16439.00650564227 16166.35229086401 18280.56289178872 19596.40419417785 20017.413797569792 18101.34477335527 17921.998741462237 20272.07202985722 17533.705237476293 0.9249413495499584 0.9375660354153651 0.9220157446419412 1.0425955406570941 1.1176419318543562 1.1416533771073587 1.032374191774692 1.022145547602569 1.1561773028172038 1.0 14.097843279405135 -5.850559259423388 3.956709210227743 1.0802853418984364 0.9283871076654758 0.6581462753786111 0.048368269532472 0.13271256990565367 3.922924788553403 0.014006559315126465 0.021984311214921715 1.4107197308080109e-06 5.850559259423388 -0.15189823423296056 VEANS(ph)PLPK ddPTM_A459_Selumetinib_30min_R1 2 VEANSPLPK 9 0 Q9H7C4-2;Q9H7C4 Q9H7C4-2 SYNC Syncoilin 1 VEANS(1)PLPK;VEANS(1)PLPK 102.05 0.01648 29032000.0 8939.4 10132.8 11236.1 11427.3 9495.3 9450.599999999999 9217.5 8436.0 5158.1 8343.7 True False 9147.67062695557 8946.447065389075 9710.29933547937 9431.736571987758 8636.451791531375 9355.535544458247 8522.216553948172 8212.249876010117 8752.918967281561 9414.695169520439 0.9716374733587397 0.9502641247857614 1.031398166444723 1.0018100854207674 0.9173373790679294 0.9937162463577454 0.9052036630499076 0.8722799547028168 0.92970816470178 1.0 13.200698668451066 -6.86095617060623 1.4050636531334049 0.9198120248631292 0.9844305704110142 0.2057284256479054 0.04290545022014304 0.5478973910510309 2.2444483071294847 0.02100798855806468 0.017415602731358382 1.3773484651387533e-07 6.86095617060623 0.06461854554788504 VEANS(ph)PLPK ddPTM_A459_Selumetinib_30min_R2 2 VEANSPLPK 9 0 Q9H7C4-2;Q9H7C4 Q9H7C4-2 SYNC Syncoilin 1 VEANS(1)PLPK;VEANS(1)PLPK 117.86 0.007398 19408900.0 150578.0 145119.0 145262.0 156598.0 159822.0 106493.0 130342.0 137553.0 99148.0 143526.0 True False 142209.47757149325 156249.16066886982 135916.00106930727 135269.082253382 139743.7315331919 121161.44410279646 136403.1612677733 137953.2564568749 118980.37042658417 139382.0314546677 1.0202855855042199 1.121013656051411 0.9751328750974064 0.9704915392725969 1.0025950265952452 0.8692759234335219 0.9786280185773929 0.9897492167183867 0.8536277537702632 1.0 17.088685061452892 -5.406331778070944 5.203742898589985 0.9528126889814855 1.0696995483457468 0.42882345524223386 0.053878078895525164 0.19382540563889092 7.442189485629554 0.013748080922446228 0.02935485565263132 3.923450899324098e-06 5.406331778070944 0.11688685936426124 VEAPEYIPISDDPKAS(ph)AK ddPTM_A459_Selumetinib_30min_R2 2 VEAPEYIPISDDPKASAK 18 1 Q1ED39;H3BPL4 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 VEAPEYIPIS(0.001)DDPKAS(0.999)AK;VEAPEYIPISDDPKAS(1)AK 99.055 0.0017170000000000002 9656800.0 124828.0 122466.0 108799.0 114706.0 102738.0 99504.0 120960.0 114855.0 82659.0 117998.0 True False 117890.5594860761 131858.7484097447 101798.99079139456 99082.84492111314 89831.13395062658 113209.77279262154 126584.87967769278 115189.20903473125 99193.10968542975 114591.09114437697 1.0287934106285979 1.1506893519637722 0.8883674094972599 0.864664468516802 0.7839277299266264 0.9879456741535425 1.1046659772024026 1.0052195845626488 0.8656267140388181 1.0 16.806135360927513 -5.264169602966724 24.90075559145803 0.9374170027557126 1.0897413837096868 0.30897788475512855 0.09103851083913052 277.87200506694114 2534337.552616648 0.026226393317039333 0.058834317371801 5.442900523164064e-06 5.264169602966724 0.15232438095397416 VEAPSLDVHMDS(ph)PDINIEGPDVK ddPTM_A459_Selumetinib_30min_R1 1 VEAPSLDVHMDSPDINIEGPDVK 23 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VEAPS(0.001)LDVHMDS(0.999)PDINIEGPDVK 51.621 0.02424 7091000.0 1247.4 1595.3 1217.1 1548.7 1525.2 1287.0 1219.9 1186.1 746.26 1087.2 True False 1276.4619929821229 1408.5215343651505 1051.8245050517473 1278.248617699496 1387.245929295931 1274.0539485025033 1127.8819608528747 1154.6407750042192 1266.3487153260965 1226.752710224794 1.0405210294976401 1.1481707133192707 0.8574054870920217 1.0419774148819818 1.1308276865691438 1.0385580874478293 0.9194044989280667 0.9412172195589763 1.0322770879340846 1.0 10.260628743370898 -7.163351235919715 8.485299701904529 0.9684442391520196 1.043500794312996 0.15850318738683833 0.07839104614045682 0.618383775275085 48.58753464690323 0.03090066308960346 0.023923532712787014 6.865129976434834e-08 7.163351235919715 0.07505655516097631 VEDLAWHR ddPTM_A459_Selumetinib_30min_R1 2 VEDLAWHR 8 0 B4DEY6;Q9NZU5-2;Q9NZU5 B4DEY6 LMCD1 LIM and cysteine-rich domains protein 1 0 ; 101.64 0.024703 0.0 3120.0 4284.4 3833.7 4238.9 3944.5 3621.6 3887.4 3650.5 2157.15 3409.8999999999996 False True 3192.689929536813 3782.780456236476 3313.104597006724 3498.6556890078086 3587.720671458037 3585.1699921497025 3594.1702882363065 3553.676881504849 3660.5259979976013 3847.593880238709 0.8297887014361128 0.983154816745313 0.8610847974425968 0.9093100254101527 0.9324582539453075 0.9317953255314135 0.9341345266962843 0.9236101813542689 0.9513805541686998 1.0 11.909740813009583 -14.522878184181625 0.047613912877386685 1.3552128002780628 0.737402955343408 0.41720025078739587 0.036835852650623675 622.6088762724966 2.189709767796048 28.52886361397333 6.817550477839124 3.0000038759350975e-15 14.522878184181625 -0.6178098449346547 VEDLAWHR ddPTM_A459_Selumetinib_30min_R2 2 VEDLAWHR 8 0 B4DEY6;Q9NZU5-2;Q9NZU5 B4DEY6 LMCD1 LIM and cysteine-rich domains protein 1 0 ; 127.46 0.00643 4703600.0 71319.0 61643.0 71576.0 69324.0 75988.0 54455.0 56600.0 51864.0 48533.0 63155.0 False True 67355.37549257744 66370.81988651458 66970.87808605652 59881.95160942978 66441.70809866082 61955.68195672741 59232.01215077233 52014.91565345262 58240.956125321776 61331.55105360375 1.0982173829862687 1.0821643794481328 1.0919482213571283 0.976364539633002 1.0833201991025923 1.0101763430469608 0.9657673926916275 0.8480939216422492 0.9496084009748784 1.0 15.90434181624543 -7.1782413316580795 2.1937844620877 0.9232363819300234 1.0637120227361831 0.5924344517883844 0.04867286187316477 0.20935194135286295 1.9725880460279368 0.022653890988377248 0.015668631403004542 6.633743396786955e-08 7.1782413316580795 0.1404756408061597 VEDVSAVEIVGGATR ddPTM_A459_Selumetinib_30min_R2 1 VEDVSAVEIVGGATR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 111.12 0.04615 1045800.0 5992.6 4734.3 5935.2 7972.0 9617.9 6041.7 6261.6 7362.8 5001.7 7003.8 False True 5659.5552822784975 5097.405586826187 5553.335693757154 6886.199847532938 8409.613416883063 6873.8893339080005 6552.776807125016 7384.22452902284 6002.179759174624 6801.582095942206 0.8320939455623072 0.7494441021107834 0.8164770512834433 1.0124408924860606 1.2364201884588295 1.0106309439400771 0.9634194978010151 1.0856627803446255 0.8824681779192959 1.0 12.731654651096939 -5.75824549563283 4.690551536790268 1.037714138879292 0.7901945653520178 0.5861718282086645 0.08783183244692343 0.12717451542523212 7.119416106938267 0.025146426586752098 0.041641097206417226 1.7448355629017151e-06 5.75824549563283 -0.24751957352727427 VEEAS(ph)PGRPSSVDTLLSPTALIDSILR ddPTM_A459_Selumetinib_30min_R2 1 VEEASPGRPSSVDTLLSPTALIDSILR 27 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 1 VEEAS(0.749)PGRPS(0.071)S(0.179)VDT(0.001)LLSPTALIDSILR 64.545 0.036546 0.0 0.0 0.0 0.0 419.09 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 362.00921902942565 0.0 0.0 0.0 0.0 0.0 0.0 0.0 VEEASPGRPS(ph)SVDTLLSPTALIDSILR ddPTM_A459_Selumetinib_30min_R2 1 VEEASPGRPSSVDTLLSPTALIDSILR 27 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 1 VEEAS(0.134)PGRPS(0.637)S(0.217)VDT(0.007)LLS(0.003)PT(0.003)ALIDSILR 72.158 0.00022498 56114000.0 79941.0 79175.0 94804.0 94721.0 102080.0 92846.0 80762.0 79396.0 71709.0 87869.0 True False 75498.19924917823 85247.4679122497 88704.4138547907 81819.83639716086 89255.79779322124 105634.6937279279 84517.59302686705 79627.02921528471 86052.80371686678 85331.99365892024 0.8847584125474839 0.9990094483552278 1.0395211696254318 0.9588412609249728 1.0459828015970751 1.237926001707629 0.9904560927603728 0.9331438983315121 1.0084471254805984 1.0 16.380799134447138 -4.730666617325078 2.5181225248101273 1.0290773801409852 0.8409741289217961 0.22787106347603103 0.07806715001141526 1.040969916645109 7.434014015655281 0.021910794440516374 0.4485541518651427 1.8592311312956944e-05 4.730666617325078 -0.18810325121918903 VEEASPGRPSSVDTLLSPTALIDSILR ddPTM_A459_Selumetinib_30min_R1 1 VEEASPGRPSSVDTLLSPTALIDSILR 27 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 0 254.61 1.5537999999999993e-62 17795000.0 1084.0 1012.1 946.0 942.09 995.17 779.79 1246.8 1039.2 577.38 920.25 False True 1109.2550909031745 893.6028614874753 817.5383960060412 777.571666719518 905.1570492115337 771.9460205926705 1152.7528721955616 1011.6370402026681 979.7716898332775 1038.373051494083 1.0682625953236184 0.8605797889320198 0.7873262839686666 0.7488365242151596 0.8717069919227306 0.7434187737075236 1.1101529171398477 0.9742520173718441 0.9435642502697024 1.0 10.02010913187493 -7.259862985230734 24.996971255519117 1.0048466292724918 0.8413110225920457 0.40679364361030435 0.09468657647667637 149.89346409093642 2376893.101444201 0.03858260542657536 0.028285639898822868 5.4971427485117974e-08 7.259862985230734 -0.1635356066804461 VEEEGS(ph)PGDPDHEASTQGR ddPTM_A459_Selumetinib_30min_R2 1 VEEEGSPGDPDHEASTQGR 19 0 Q9NZT2-2;Q9NZT2;A0A0A0MRN5 Q9NZT2-2 OGFR Opioid growth factor receptor 1 VEEEGS(1)PGDPDHEASTQGR 110.16 0.00044124 3859400.0 7255.7 7172.3 8943.9 10141.0 11495.0 9753.7 9938.1 10828.0 11281.0 8347.8 True False 6852.457240868422 7722.39234742062 8368.459211382027 8759.778305799247 10050.895333396142 11097.183639726982 10400.24134197156 10859.507687328101 13537.515217475835 8106.777323810831 0.8452751281007458 0.9525847373084723 1.032279397486668 1.0805500084565607 1.2398139151886092 1.3688773228213478 1.2829069957829577 1.3395591433641683 1.669900957771975 1.0 12.984912800466315 -5.9818681837397945 0.912109895524967 1.3644280825460695 0.8684418149901951 0.5576147896969306 0.1550116799425224 0.4596909053506412 0.7686034597277852 0.06693620561599366 0.15500137191624674 1.042633839672897e-06 5.9818681837397945 -0.4959862675558744 VEEESTGDPFGFDS(ph)DDESLPVSSK ddPTM_A459_Selumetinib_30min_R1 1 VEEESTGDPFGFDSDDESLPVSSK 24 0 Q7Z5K2;Q7Z5K2-2;Q7Z5K2-3 Q7Z5K2 WAPAL Wings apart-like protein homolog 1 VEEESTGDPFGFDS(0.715)DDES(0.264)LPVS(0.009)S(0.011)K 56.681 0.0089169 4155400.0 3213.4 3753.9 3409.6 3568.7 3227.5 3145.7 4058.0 3330.5 1586.2 2872.1 True False 3288.2659678120517 3314.391642859235 2946.5950475921786 2945.493537795694 2935.5731948614048 3114.0571140670754 3751.9017928854573 3242.1643210113434 2691.6655485357037 3240.7620116230983 1.014658267413213 1.0227198513720113 0.9092290754532791 0.9088891832327044 0.905828068933441 0.9609027453723564 1.1577220972811764 1.0004327097711019 0.8305656320587436 1.0 11.662117363553646 -7.024078727790583 24.955880934690985 1.006087051161119 0.9495770886158148 0.05823247456110514 0.08285701397899681 2073.303317902775 2148824.0186181245 0.033296230637330476 0.025944839636280394 9.460656454648374e-08 7.024078727790583 -0.05650996254530427 VEEGGRHPS(ph)PCQFTIATPK ddPTM_A459_Selumetinib_30min_R2 2 VEEGGRHPSPCQFTIATPK 19 1 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 VEEGGRHPS(0.781)PCQFT(0.194)IAT(0.025)PK;VEEGGRHPS(0.993)PCQFT(0.006)IAT(0.001)PK 89.374 0.0016101 16857200.0 55738.0 50419.0 56715.0 62291.0 57748.0 42061.0 33093.0 38311.0 37134.0 53474.0 True False 52640.305096892625 54285.97517736297 53066.01864662303 53806.858342031446 50493.179966329786 47854.52095825751 34631.890072535454 38422.4786672725 44561.837610650444 51930.06667786249 1.0136768247080434 1.0453669453982195 1.0218746487619048 1.0361407520581718 0.9723303511153542 0.9215185733365838 0.6668947738381943 0.7398888760459035 0.8581124666579124 1.0 15.664282457387246 -6.919883922838853 2.906182639641716 0.7943129291867962 1.022792317892469 0.5516802353926888 0.08396534330985748 0.17374085789609695 2.9688243786501873 0.0317028914400481 0.026929384526987257 1.2025858158460812e-07 6.919883922838853 0.22847938870567275 VEENPDADS(ph)DFDAK ddPTM_A459_Selumetinib_30min_R1 2 VEENPDADSDFDAK 14 0 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 VEENPDADS(1)DFDAK;VEENPDADS(1)DFDAK 143.28 0.00053922 16134200.0 9647.1 10185.3 6799.799999999999 7237.0 6709.0 7424.900000000001 8526.1 8377.4 5399.5 10187.0 True False 9871.858660011085 8992.800340982494 5876.42450862778 5973.193805314942 6102.172134570157 7350.212247269809 7882.969412597506 8155.20413836974 9162.557136123143 11494.600679782909 0.8588257160924296 0.7823499564277456 0.5112334627651253 0.5196521368350618 0.5308729119492479 0.6394491163314278 0.6857975872500154 0.7094812917436434 0.7971183507260551 1.0 13.488668727527807 -8.55649341785355 1.0735454046997286 0.9982470313444323 0.6337999341600058 0.5137757629323301 0.10621799814054646 0.5143716098916497 1.2941709694464352 0.11293101356628765 0.036517162969195244 2.77655692715095e-09 8.55649341785355 -0.36444709718442647 VEENPDADS(ph)DFDAK ddPTM_A459_Selumetinib_30min_R2 1 VEENPDADSDFDAK 14 0 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 VEENPDADS(1)DFDAK 88.427 0.020803 8608900.0 22048.0 18497.0 21528.0 16593.0 16680.0 14753.0 16666.0 15590.0 11236.0 16062.0 True False 20822.660425137045 19915.66042277083 20142.911917914138 14333.004775478445 14584.509278908028 16785.091835600026 17441.002023052486 15635.364318936563 13483.513960070777 15598.248325912184 1.3349358203604147 1.276788265364801 1.2913573048104543 0.9188855361193419 0.9350094301729953 1.0760882558662839 1.1181385023906227 1.0023794975082376 0.8644248814574673 1.0 13.929096403931068 -5.75166039238215 24.969636950927786 0.9948497513038609 1.2986033743070502 0.8040961646311096 0.07077681630574076 92.66054874842445 236596.7973814931 0.021032491180257393 0.03585798071435852 1.7714936813851429e-06 5.75166039238215 0.3037536230031893 VEEPSQCLASGTAISELIIEDNNAS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 VEEPSQCLASGTAISELIIEDNNASPQK 28 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 VEEPSQCLASGTAISELIIEDNNAS(1)PQK 232.39 1.6999e-49 11631000.0 2560.9 4799.6 2476.9 1878.3 2224.2 3302.3 3798.9 3318.6 1264.1 3515.1 True False 2620.5639873560335 4237.660600726497 2140.550584637807 1550.2901650577653 2023.0215027144038 3269.0818602484974 3512.345914488062 3230.579947667988 2145.08537378892 3966.297324973484 0.6607079027726578 1.0684172802791145 0.5396848519549948 0.3908658474231075 0.5100529125682549 0.8242150278712028 0.8855478111468971 0.8145077594982332 0.540828182567796 1.0 11.953577114822581 -6.78949825928894 24.893740733904377 0.8059595821411958 0.6393418657485136 0.17067194951750586 0.19688491840397102 454.247785933606 403003.73531752074 0.0750609888851048 0.06621115337247424 1.6236848584180583e-07 6.78949825928894 -0.1666177163926822 VEEPSQCLASGTAISELIIEDNNAS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 3 VEEPSQCLASGTAISELIIEDNNASPQK 28 0 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 VEEPSQCLASGTAISELIIEDNNAS(1)PQK;VEEPSQCLASGTAISELIIEDNNAS(1)PQK;VEEPSQCLASGTAISELIIEDNNAS(1)PQK 147.71 3.1532999999999995e-14 11169300.0 119367.0 88427.3 123590.5 128628.0 137223.0 106044.5 116435.6 133398.0 109306.4 110634.0 True False 112733.06000396116 95209.38957141583 115638.82178516198 111108.64450432359 119983.81995081512 120651.16729887403 121850.08611276434 133786.1660947723 131170.73427599485 107439.70895834692 1.0492681067077947 0.886165743508551 1.0763136172492218 1.0341487852261315 1.1167548861969776 1.1229662521298251 1.1341252437681506 1.2452208535546163 1.2208776024034853 1.0 16.71316777622733 -6.145242890990554 0.9517457550574129 1.1673208795481762 0.9726824713688142 0.4136580094957696 0.07640670920314935 0.5025593826599282 0.950329397114486 0.033979975036183274 0.06212805484884097 7.157429995309224e-07 6.145242890990554 -0.19463840817936195 VEEPSQCLASGTAISELIIEDNNAS(ph)PQKLR ddPTM_A459_Selumetinib_30min_R1 2 VEEPSQCLASGTAISELIIEDNNASPQKLR 30 1 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 VEEPSQCLASGTAIS(0.001)ELIIEDNNAS(0.999)PQKLR;VEEPSQCLASGTAIS(0.001)ELIIEDNNAS(0.999)PQKLR 137.84 2.6279e-18 30577000.0 1906.78 1991.29 3398.2 3588.7 2411.9900000000002 2522.19 2111.42 2200.8599999999997 1072.96 1215.81 True False 1951.204264051988 1758.148841074395 2936.7431049764614 2962.000913242191 2193.825930371422 2496.8190585652924 1952.153889486005 2142.486043399195 1820.7347541021752 1371.8710564922799 1.422294212577819 1.281570037325362 2.1406844987934823 2.159095710361945 1.5991487829627287 1.8200100124201017 1.4229864244511747 1.5617255231532408 1.3271908795551015 1.0 10.421929172221457 -8.339953066543208 0.8339792149687705 1.0102102429970132 1.7432067404986948 0.41487702860507425 0.27006537196531233 0.6427489017393777 0.9847463025522727 0.28156749455529123 0.1048283637575558 4.571375890176144e-09 8.339953066543208 0.7329964975016816 VEEPSQCLASGTAISELIIEDNNAS(ph)PQKLR ddPTM_A459_Selumetinib_30min_R2 2 VEEPSQCLASGTAISELIIEDNNASPQKLR 30 1 Q5UIP0;Q5UIP0-2;H7C2B5 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 VEEPSQCLASGTAISELIIEDNNAS(1)PQKLR;VEEPSQCLASGT(0.001)AIS(0.077)ELIIEDNNAS(0.922)PQKLR 90.833 5.5839e-07 5243000.0 18194.5 22331.7 19244.3 23428.1 24642.3 12836.599999999999 8438.4 6379.8 4580.3 21717.6 True False 17183.322528354318 24044.469582266935 18006.14268960959 20237.152364273268 21546.513969042888 14604.725130947163 8830.80232037238 6398.364161767257 5496.487984274853 21090.556458898667 0.8147401213354054 1.1400585674031343 0.8537537985164123 0.9595361982843594 1.0216190365120423 0.6924769936444726 0.41870883480869137 0.3033757868947842 0.26061370144436086 1.0 14.364309539636142 -7.004063953638766 3.073596333551081 0.4401354379446926 0.9617309775836381 0.5142569850110223 0.20899235029536253 0.1808930256657957 3.503721530768638 0.0790350166180387 0.06386962727200621 9.906860470159653e-08 7.004063953638766 0.5215955396389456 VEESSEIS(ph)PEPK ddPTM_A459_Selumetinib_30min_R1 1 VEESSEISPEPK 12 0 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 VEES(0.003)S(0.053)EIS(0.944)PEPK 129.76 0.0022633 7675800.0 3497.9 3779.3 2609.7 2152.1 2306.9 2235.9 3243.0 3249.2 2075.1 3267.2 True False 3579.394264271416 3336.8177990510953 2255.3170740559904 1776.2761349203095 2098.2413023162762 2213.4088760347695 2998.37789904572 3163.020661110961 3521.2931406924986 3686.5769452229993 0.9709262325066974 0.9051263132795545 0.6117645467778423 0.4818226124974759 0.5691570618199465 0.600396766139078 0.8133230212191731 0.8579830851515379 0.9551660505161373 1.0 11.848066153481307 -7.7873974017296925 1.8063445064135528 0.9697716027149105 0.6834469098406579 0.3831762276890486 0.14314453755981182 0.44233743907083695 2.7650635175500877 0.12425938717895499 0.04873662754623013 1.6315583050726594e-08 7.7873974017296925 -0.28632469287425255 VEET(ph)SPLGNAR ddPTM_A459_Selumetinib_30min_R1 1 VEETSPLGNAR 11 0 P30414;A0A087WYW3 P30414 NKTR NK-tumor recognition protein;Putative peptidyl-prolyl cis-trans isomerase 1 VEET(0.847)S(0.153)PLGNAR 111.5 0.019208000000000003 6172400.0 3846.9 3961.6 3268.1 2795.2 3635.2 3390.9 4252.4 4079.3 2117.2 3797.4 True False 3936.5252852356316 3497.774030302125 2824.3099703883145 2307.0707924024196 3306.3968018466867 3356.7906246908606 3931.6380443731177 3971.1037125661514 3592.733765830155 4284.833279808347 0.9187114242661282 0.8163150820324506 0.6591411581163412 0.5384272016542989 0.7716512139288128 0.7834121902733644 0.9175708335958811 0.9267813829022007 0.838476909419181 1.0 12.065023355727279 -7.114683036893054 2.4780241761472497 0.9168714097884133 0.7299515589792815 0.4206204010589969 0.0998755930961019 0.32560717468012146 3.9083864343627726 0.047746935498965554 0.035217129676281364 7.679217406904864e-08 7.114683036893054 -0.18691985080913176 VEET(ph)SPLGNAR ddPTM_A459_Selumetinib_30min_R2 2 VEETSPLGNAR 11 0 P30414;A0A087WYW3 P30414 NKTR NK-tumor recognition protein;Putative peptidyl-prolyl cis-trans isomerase 1 VEET(0.628)S(0.372)PLGNAR;VEET(0.872)S(0.128)PLGNAR 145.28 0.001648 26662000.0 109242.0 89969.0 103640.0 133693.0 133113.0 100390.0 137024.0 151139.0 116267.0 103193.0 True False 103170.76697037459 96869.33300406935 96971.91523470017 115483.78276671103 116390.15489468115 114217.81125031436 143395.88750790487 151578.7894675917 139523.64877140895 100213.54996238652 1.0295091532941205 0.9666290939740947 0.9676527303054023 1.1523769271725823 1.1614213341246393 1.139744189215771 1.4309031818723728 1.512557828003142 1.3922633099393926 1.0 16.612718064226392 -6.6339715131257675 1.1302926679852312 1.3660091770912428 0.9995547988217194 0.4599467258922615 0.14074062299886675 0.37792017334218736 1.0268865254867872 0.06917439383558442 0.07079080041676464 2.3228891576784578e-07 6.6339715131257675 -0.36645437826952343 VEETVKHDWDR ddPTM_A459_Selumetinib_30min_R1 5 VEETVKHDWDR 11 1 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 ;;;; 147.74 0.0076126000000000015 232246400.0 16051.199999999997 17132.6 26188.800000000003 27716.400000000005 22907.299999999996 18676.600000000002 18442.7 16987.6 10668.77 12598.0 False True 16425.161729801694 15126.707227270354 22632.5048047812 22876.25104126448 20835.338759612303 18488.730360996 17051.55229069705 16537.0336644985 18104.123473869164 14215.076014911663 1.1554747728799792 1.0641312935226224 1.5921479970307317 1.6092950201087364 1.4657212341148202 1.3006423842968733 1.1995400005465968 1.1633447226839375 1.2735861176456515 1.0 13.795134193376207 -7.160686129454989 2.8967241457177617 1.1688945730309188 1.3843943252877813 0.261539596829085 0.17215984875431903 0.45354738830044383 7.357064122221632 0.08233496766860146 0.06019460930802875 6.907388298647536e-08 7.160686129454989 0.21549975225686246 VEETVKHDWDR ddPTM_A459_Selumetinib_30min_R2 4 VEETVKHDWDR 11 1 Q16881;A0A087WSW9;Q16881-6;Q16881-3;Q16881-4;Q16881-2;Q16881-5;A0A087WSY9;E9PIR7;F8W809;A0A182DWI3;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 ;;; 86.014 0.027128 92651500.0 220205.0 278025.0 264339.0 260963.0 262532.0 147124.0 121870.0 151647.0 110722.0 275913.0 False True 207966.88765045837 299348.6235087242 247331.71653054142 225419.38921371583 229550.38309414178 167388.9955413015 127537.19648082356 152088.2676634875 132869.49383116362 267946.6747819327 0.7761502837074256 1.1171947692664888 0.9230632055121837 0.8412845182615998 0.8567017421692595 0.6247101057608956 0.4759797694247155 0.5676064753827003 0.4958803610431027 1.0 18.03158638675255 -6.685818823409161 2.559869037009341 0.5906150481491378 0.9267622470462412 0.40714394348530547 0.16024378908260634 0.2382608924279821 3.1851612734888826 0.05654403360491454 0.05480060940057522 2.0614897348946986e-07 6.685818823409161 0.3361471988971034 VEEVEDVS(ph)PGPWGLVK ddPTM_A459_Selumetinib_30min_R1 1 VEEVEDVSPGPWGLVK 16 0 O15061;A0A075B7B1;O15061-2;H0YL34 O15061 SYNM Synemin 1 VEEVEDVS(1)PGPWGLVK 127.75 0.0010113 2245600.0 1133.3 1143.2 475.35 632.92 700.9 722.48 1598.2 1284.9 662.14 1457.7 True False 1159.7036849820736 1009.3536125407389 410.80008091064684 522.3924033798438 637.5037187539457 715.2125071593546 1477.646487281799 1250.8202780565903 1123.6032192078117 1644.8099942004076 0.705068481509222 0.6136597030050371 0.24975534095678287 0.31760045550659166 0.38758502258727806 0.43482986465378404 0.8983691079771972 0.7604649062608914 0.6831203744928784 1.0 10.683705220441949 -7.254101785422217 24.67437479413622 0.8155273428180128 0.44064075981519846 0.6198271655859415 0.14688050428706761 350.70840486767105 1179341.4989400513 0.06123399489365809 0.04642734759139963 5.570551768347841e-08 7.254101785422217 -0.3748865830028143 VEFMDDTS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 VEFMDDTSR 9 0 P62857 P62857 RPS28 40S ribosomal protein S28 1 VEFMDDT(0.007)S(0.993)R 93.442 0.024562 4459600.0 2546.5 5066.1 4513.1 4677.0 4711.7 4162.2 4717.2 3844.7 1368.7 3026.2 True False 2605.828495373557 4472.958656834007 3900.2458086837933 3860.249748163325 4285.527566918197 4120.332046975229 4361.377806160492 3742.726066654346 2322.583934107186 3414.6422476842095 0.7631336773686365 1.309934784490979 1.142212134032172 1.1304990298123687 1.2550443812450975 1.2066658080417103 1.2772576128929327 1.0960814618845185 0.6801836812282016 1.0 11.73751871983096 -8.09779593607984 6.087798892478288 0.8454518333884411 1.166784035241904 0.3718042193497205 0.16076638560147496 0.2251505751050706 11.485387628302602 0.10473789503041474 0.038796332938025556 7.98369732760303e-09 8.09779593607984 0.321332201853463 VEFMDDTSR ddPTM_A459_Selumetinib_30min_R1 2 VEFMDDTSR 9 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 ; 158.76 0.011444 27892000.0 7116.299999999999 7360.1 7813.3 7976.700000000001 7600.5 5921.6 7577.5 7088.3 3911.3 5151.299999999999 False True 7282.095944090653 6498.376070382339 6752.296775384784 6583.719086203633 6913.036116977261 5862.034080382617 7005.923074319752 6900.295257956672 6637.190429950641 5812.519532911128 1.2528295006767065 1.1179964271238685 1.1616815629009989 1.1326790471715213 1.189335550243726 1.0085186031962785 1.2053160483421073 1.1871435818643596 1.1418783872243585 1.0 12.504947943939868 -12.022229473888629 1.633932362612877 1.2777848967845029e-05 1.152788646852368 0.36340413732116383 0.06157115579403797 1445272.3585039636 98870.69208700937 5323833.830408019 0.015046197223837406 9.501026427717891e-13 12.022229473888629 1.1527758690034002 VEFMDDTSR ddPTM_A459_Selumetinib_30min_R2 1 VEFMDDTSR 9 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 155.58 0.011444 12621000.0 37001.0 37825.0 40220.0 39108.0 41924.0 30794.0 26244.0 32027.0 32311.0 38088.0 False True 34944.63254673876 40726.05587345548 37632.288988224944 33781.422934937065 36657.13231468466 35035.59397990018 27464.398001499427 32120.193267644736 38774.10284477101 36988.30047549141 0.9447482608694933 1.1010523692604024 1.017410600229125 0.913300219276654 0.9910466780968707 0.9472074555876094 0.7425158130662814 0.8683879187400811 1.0482801952596574 1.0 15.174781393125471 -5.9800386253145605 1.3170540910473323 0.9099779520007891 1.0308520486682562 0.14633469626334505 0.08850094840945873 0.7178995534431012 2.5280686442644593 0.033336679531141354 0.0630770096467914 1.0470354225963695e-06 5.9800386253145605 0.12087409666746707 VEGFLEEDRR ddPTM_A459_Selumetinib_30min_R2 2 VEGFLEEDRR 10 1 Q9NX02;A0A0G2JMG8;A0A0G2JLX3;J3KN39;A0A0G2JNC8;A0A0G2JP37;A0A0G2JPQ2;A0A0G2JPB6;A0A0G2JLQ8;Q9NX02-5;Q9NX02-2;Q9NX02-4;Q9NX02-3;Q8WX94;K7ERG0;Q8WX94-3;A0A0G2JM25;A0A0G2JNK1;A0A0G2JMB6;A0A0G2JPH3;Q8WX94-2;A0A0G2JNK3 Q9NX02 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 ; 150.81 0.00094152 4947300.0 16940.8 15951.599999999999 20590.0 20853.0 23079.0 15468.2 15490.0 15320.199999999999 13058.5 19957.1 False True 15999.298155395572 17175.036427521823 19265.261816696955 18012.78542656853 20179.6096911222 17598.804143660844 16210.3156928527 15364.77924560436 15670.564884975465 19380.886668226998 0.825519411432543 0.8861842454132172 0.9940340783417511 0.9294097703021332 1.041211892756415 0.9080494842639115 0.8364073311169954 0.7927799954990378 0.8085576864068748 1.0 14.242346954564171 -7.145645023756716 4.539674345272943 0.8425861262893294 0.938561515899493 0.1644084610180534 0.07609848094899231 0.3333337766880461 10.966208978074006 0.030155038941571115 0.02309151046020194 7.150805676766888e-08 7.145645023756716 0.09597538961016361 VEGIYTYSLS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 VEGIYTYSLSPSK 13 0 O95197-7;O95197-2;O95197 O95197-7 RTN3 Reticulon-3 1 VEGIYT(0.005)YS(0.213)LS(0.518)PS(0.265)K 78.505 0.040963 3465100.0 17575.0 7531.3 11272.0 15672.0 15241.0 11428.0 18996.0 14158.0 13576.0 10542.0 True False 16598.251858299325 8108.92649305368 10546.771792025647 13537.44656429206 13326.289323731244 13002.10326694483 19879.351639859895 14199.197436016917 16291.579345133581 10237.625068594576 1.621299055893042 0.7920710554178242 1.0301971132327774 1.3223229482998136 1.3016973403930958 1.2700312015557884 1.941793287668127 1.3869620484124827 1.5913436208081504 1.0 13.321593456298665 -6.555584181294254 1.5481825342325595 1.5026349137253399 1.1408477160169217 0.1281258066768023 0.2986687584248419 0.6083882643166307 2.9882833618741422 0.11847198517738626 0.12713421935864813 2.7823760008593044e-07 6.555584181294254 -0.36178719770841816 VEGNAVACPVSSAQS(ph)PPHSAGAPAAK ddPTM_A459_Selumetinib_30min_R2 2 VEGNAVACPVSSAQSPPHSAGAPAAK 26 0 Q8NEZ4;Q8NEZ4-3;H7BY37;Q8NEZ4-2;H0Y765 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 1 VEGNAVACPVS(0.002)S(0.005)AQS(0.993)PPHS(0.001)AGAPAAK;VEGNAVACPVSS(0.001)AQS(0.999)PPHSAGAPAAK 126.23 4.7834e-09 21628000.0 135855.0 110881.0 143400.0 146121.0 157304.0 119850.0 124159.0 133362.0 119111.0 132550.0 True False 128304.72297065456 119385.21616139136 134173.80012211466 126219.06772721506 137542.06520439743 136358.2496100225 129932.63951639111 133750.06134073244 142936.52823940822 128722.93709374052 0.9967510520461369 0.9274587642018368 1.0423457011737125 0.980548382261492 1.0685124835539956 1.0593158662214308 1.0093977223481907 1.0390538342310431 1.1104200344288047 1.0 16.973909624211117 -5.684721945565081 1.2392520514011125 1.0470685318852897 0.9641686095914843 0.3450747412811588 0.03964315526545132 0.5511956014435323 1.6278580915305714 0.01328034853414915 0.03858473941286111 2.0667029264593717e-06 5.684721945565081 -0.08289992229380538 VEGNFNPFAS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 1 VEGNFNPFASPQK 13 0 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 VEGNFNPFAS(1)PQK 93.716 0.016744 6120500.0 22427.0 30361.0 33229.0 32519.0 30968.0 31213.0 31196.0 30105.0 27063.0 30412.0 True False 21180.59712239427 32689.591073998236 31091.082316999695 28089.85610159605 27077.522982567374 35512.307426596904 32646.67581370127 30192.600565848974 32476.356203399413 29533.92654013454 0.7171615698851055 1.1068487974186354 1.0527243058842544 0.9511046918676358 0.9168277352410596 1.2024241808260125 1.1053957139541442 1.0223022842837826 1.0996288000942345 1.0 14.850085555303242 -6.740595740377185 24.995702443740115 1.088559484922832 0.9635932758815294 0.28119330280414956 0.10823218518960036 356.96872960536246 428076.1964856484 0.03553862651884962 0.03550242635194688 1.8172064081191224e-07 6.740595740377185 -0.12496620904130251 VEGVHT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 VEGVHTPR 8 0 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 VEGVHT(1)PR 94.409 0.030801 9444900.0 7439.7 9417.9 5765.0 5350.1 6936.3 5324.8 6757.8 5845.9 3449.8 6890.7 True False 7613.03053486379 8315.24788973707 4982.1446648782585 4415.805468815182 6308.912889703231 5271.237346531569 6248.053705264006 5690.847741840625 5854.0586365770205 7775.188466101907 0.979144179984178 1.0694593354218618 0.6407747782062521 0.5679354896755381 0.8114160727046924 0.677956215404037 0.803588714602113 0.7319240898984578 0.7529153360203955 1.0 12.924661930428186 -5.255630607006597 24.996850526583984 0.7340125940640913 1.0243017850494749 0.489408596548924 0.11199944589309704 347.67712295104224 1496145.4548495042 0.02753540545654264 0.06878733353301525 5.55097655417764e-06 5.255630607006597 0.29028919098538364 VEGVHT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VEGVHTPR 8 0 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 VEGVHT(1)PR 90.913 0.037419 17263000.0 245710.0 188080.0 189220.0 195490.0 236990.0 174550.0 222890.0 206450.0 163770.0 164280.0 True False 232054.42185506297 202505.1312274819 177045.7912071592 168863.92476093996 207217.19748251897 198592.6780928613 233254.8266481559 207050.73532036264 196528.57611612594 159536.8095492999 1.4545509748541996 1.2693317097137007 1.1097488517372456 1.058463719050103 1.2988676285298593 1.244807882606505 1.4620752872463312 1.297824219409252 1.2318697902467133 1.0 17.283529806435553 -8.653652661820724 6.210963110304582 1.0000004945282437 1.26756433314331 0.31682188082393525 0.11993551067141944 4.662048526943839 221.3411421485301 0.12547814726707465 0.032505870420660214 2.2199711890393446e-09 8.653652661820724 0.2675638386150663 VEHS(ph)PGPPLADAECQEGLSENSACR ddPTM_A459_Selumetinib_30min_R1 2 VEHSPGPPLADAECQEGLSENSACR 25 0 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2 Q3T8J9-3 GON4L GON-4-like protein 1 VEHS(1)PGPPLADAECQEGLSENSACR;VEHS(1)PGPPLADAECQEGLSENSACR 170.55 1.9295e-16 7291400.0 1368.82 1714.05 1716.9 1674.73 1656.55 1476.44 1546.65 1403.9299999999998 1035.56 1407.0700000000002 True False 1400.7108427399305 1513.3682291597731 1483.7544102566303 1382.269844075596 1506.7153449876566 1461.5883541002624 1429.9849452849405 1366.6932157926597 1757.2696856900984 1587.681140522445 0.8822368717430317 0.9531940580095205 0.934541812198124 0.8706218199585994 0.9490037429630577 0.9205805352196283 0.9006751474130298 0.8608108901154632 1.1068152419520763 1.0 10.632705484814673 -8.260762596742689 24.99985315199496 1.0534076259743503 0.9114537241528636 0.6943342417423317 0.03830811617333263 31.515722777784784 1164293.9105823815 0.028643934647737717 0.009301917857788635 5.485767576316689e-09 8.260762596742689 -0.1419539018214867 VEHS(ph)PGPPLADAECQEGLSENSACR ddPTM_A459_Selumetinib_30min_R2 2 VEHSPGPPLADAECQEGLSENSACR 25 0 Q3T8J9-3;Q3T8J9;A0A087WUE6;Q3T8J9-2 Q3T8J9-3 GON4L GON-4-like protein 1 VEHS(1)PGPPLADAECQEGLSENSACR;VEHS(1)PGPPLADAECQEGLSENSACR 132.37 3.6024e-08 14788900.0 46148.0 45833.0 46606.0 55847.0 55958.0 44152.0 38442.0 45319.0 38816.0 50149.0 True False 43583.27890508093 49348.24372367707 43607.42070077602 48240.54225855147 48928.055769132814 50233.5372280494 40229.62917137791 45450.87078703567 46580.284609657116 48701.068067250024 0.8949142315502799 1.0132887364099157 0.8954099454360976 0.9905438252799174 1.0046608362175826 1.0314668491188577 0.8260522975764283 0.9332622997974861 0.956453040112706 1.0 15.571665792071196 -10.129721140849531 13.734837441604878 1.0000121649280125 0.9509659003025602 0.0578662477451416 0.06081881707860374 0.0 0.0 0.05938183202032944 0.014402209744853135 7.417863871753233e-11 10.129721140849531 -0.04904626462545225 VEHS(ph)PGPPPVDK ddPTM_A459_Selumetinib_30min_R2 1 VEHSPGPPPVDK 12 0 Q9H869-7;Q9H869-5;Q9H869-6;Q9H869-4;Q9H869-3;Q9H869-2;Q9H869;Q9H869-8;Q9H869-9 Q9H869-7 YY1AP1 YY1-associated protein 1 1 VEHS(1)PGPPPVDK 73.80199999999998 0.035143 10229000.0 63195.0 50336.0 63148.0 62355.0 63200.0 52260.0 57268.0 53552.0 43310.0 67500.0 True False 59682.8748896288 54196.60934425002 59085.12643034385 53862.14143162528 55260.25098483136 59458.34063095353 59931.075474389174 53707.82745398918 51973.21018250855 65551.09961393785 0.9104786226490499 0.8267841373133339 0.9013598059883778 0.8216817375886216 0.8430102822116747 0.9070532909612877 0.9142649906310082 0.819327635543882 0.7928655734015743 1.0 16.000332361282048 -6.726010747228524 24.99464106774862 0.8771330714935646 0.8588760956360698 0.03376866167438153 0.05911471075088171 980.7403305620373 691903.6411262096 0.01937803258654581 0.019377466026984112 1.8792703110376285e-07 6.726010747228524 -0.01825697585749475 VEILANDQGNR ddPTM_A459_Selumetinib_30min_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 161.51 0.0084938 32112000.0 2578.9 2253.5 2239.9 2419.0 2875.2 2138.0 2221.6 2753.4 1336.7 2162.1 False True 2638.983352334131 1989.659172376271 1935.7338828899938 1996.5670602538116 2615.13866765779 2116.49366114868 2054.0229233795776 2680.370887696329 2268.282271294713 2439.626595637441 1.0817160941978503 0.8155588957483063 0.7934549846076805 0.8183904306602036 1.0719421866994732 0.8675481997668866 0.8419415196787071 1.0986807950402693 0.9297661680483698 1.0 11.252444633332692 -7.750324826412316 24.999817243615052 1.0106676294523604 0.893790447704296 0.1936467479361642 0.10329995156204055 332.93105940776155 748861.5269709087 0.04964995787875584 0.028319396349529565 1.776949860202234e-08 7.750324826412316 -0.11687718174806438 VEKEEAGGGIS(ph)EEEAAQYDR ddPTM_A459_Selumetinib_30min_R1 1 VEKEEAGGGISEEEAAQYDR 20 1 A0A590UK93;A0A590UKC5;M0QZS6;B3KNJ4;Q9UBE0-2;Q9UBE0-3;Q9UBE0;M0R375 A0A590UK93 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 VEKEEAGGGIS(1)EEEAAQYDR 58.054 0.020148 6629600.0 648.17 938.73 787.94 893.14 742.57 619.66 934.33 656.4 356.92 703.38 True False 663.2710998807297 828.8230551962623 680.9420758446093 737.1698653142164 675.4046746113817 613.4267830062635 863.8527358666015 638.9901397123086 605.6671715946055 793.6656745013944 0.835705916470959 1.0442974691036688 0.8579709287193231 0.9288166151034938 0.8509939339832128 0.7729032547509849 1.0884340391932672 0.8051124802817536 0.7631263276884245 1.0 9.632387601030304 VEKEEAGGGIS(ph)EEEAAQYDR ddPTM_A459_Selumetinib_30min_R2 1 VEKEEAGGGISEEEAAQYDR 20 1 A0A590UK93;A0A590UKC5;M0QZS6;B3KNJ4;Q9UBE0-2;Q9UBE0-3;Q9UBE0;M0R375 A0A590UK93 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 VEKEEAGGGIS(1)EEEAAQYDR 64.589 0.009823299999999998 4224400.0 11281.0 11132.0 10539.0 13856.0 11862.0 10462.0 12299.0 8554.7 8550.7 12371.0 True False 10654.047181421034 11985.788604978361 9860.932213995598 11968.788897066785 10371.789512374515 11903.045535419746 12870.927870006151 8579.592760693173 10261.078926519876 12013.817086281879 0.8868161638307683 0.9976669795201458 0.8207992633128585 0.9962519664739602 0.8633217434463578 0.9907796539545605 1.071343751745894 0.7141437812042173 0.8541064719752236 1.0 13.552406983259038 -7.762478146130797 24.99996146345805 0.838093888595809 0.9442214574766653 0.1516729320383624 0.09528808390792962 43.85758713568098 1055415.2679731785 0.04666389387871266 0.02441905701073299 1.7279129275786046e-08 7.762478146130797 0.10612756888085628 VELQELNDR ddPTM_A459_Selumetinib_30min_R1 2 VELQELNDR 9 0 P08670;B0YJC4;A0A1B0GTT5;P17661 P08670 VIM;DES Vimentin;Desmin 0 ; 179.1 0.0087309 68645000.0 7051.3 7470.1 5005.200000000001 4808.9 6703.1 5411.6 6616.2 6363.9 3461.0 5357.200000000001 False True 7215.581570558632 6595.497219244725 4325.521331595602 3969.1158892329736 6096.805788528424 5357.1642173396685 6117.13470726682 6195.108699139493 5873.064218561387 6044.848803546975 1.193674449942354 1.0910938277520923 0.7155714679013124 0.6566112765143091 1.0085952497192257 0.8862362635433015 1.011958264973878 1.024857510994212 0.9715816572806933 1.0 12.561490539256264 -7.27038202320866 23.099071281194096 1.004170834624092 0.9148736105252286 0.05623006342343895 0.15045801124600902 775.6078588052545 2003395.788395658 0.06873588285476186 0.04722491045210603 5.365596089213177e-08 7.27038202320866 -0.08929722409886343 VELQELNDR ddPTM_A459_Selumetinib_30min_R2 3 VELQELNDR 9 0 P08670;B0YJC4;A0A1B0GTT5;P17661 P08670 VIM;DES Vimentin;Desmin 0 ;; 150.81 0.017731 105729000.0 156966.0 131403.0 158778.0 164317.0 170637.0 142086.0 145518.0 138331.0 134671.0 149813.0 False True 148242.4581046835 141481.18757276057 148562.3963444151 141936.7411373647 149200.05454586487 161657.05677171194 152284.87533844655 138733.52030807006 161608.96302213342 145487.50942907992 1.018935980734116 0.9724627779247792 1.0211350577613267 0.9755939990611627 1.0255179646098396 1.1111404505176035 1.0467213023031376 0.9535768455483652 1.1108098809053581 1.0 17.15053577287454 -6.51618470448303 24.880639932207444 1.0446501074695085 0.997443322974654 0.19072414342483457 0.04605973897343677 501.8554410308942 1865322.2212655272 0.01473302923360015 0.015269995273914585 3.046599002236897e-07 6.51618470448303 -0.04720678449485449 VELS(ph)PGPPKPAGR ddPTM_A459_Selumetinib_30min_R1 2 VELSPGPPKPAGR 13 1 A0A087WXE2;Q8IZ73-2;Q8IZ73 A0A087WXE2 RPUSD2 RNA pseudouridylate synthase domain-containing protein 2 1 VELS(1)PGPPKPAGR;VELS(1)PGPPKPAGR 83.85600000000002 0.016600999999999998 75769000.0 11546.5 12672.3 12158.3 11855.3 11424.3 10028.900000000001 10928.7 10033.3 5915.799999999999 10081.4 True False 11815.510984422059 11188.621224807563 10507.269640761371 9784.994406542799 10390.974082123977 9928.018371512633 10104.339360253149 9767.184291248488 10038.680527063116 11375.445891151807 1.0386855247241384 0.983576497296729 0.9236798048447726 0.8601855698820463 0.9134564202187816 0.8727586124105228 0.8882587510800464 0.8586199068333421 0.8824867722215205 1.0 13.473635476275788 -5.140277285422965 1.8686315276636678 0.889820328211956 1.0425291683906814 0.5822639254607215 0.03906351443487957 0.27559270537621955 1.5789577012091986 0.010179956839508003 0.05696955783444717 7.2397357469644285e-06 5.140277285422965 0.15270884017872544 VELS(ph)PGPPKPAGR ddPTM_A459_Selumetinib_30min_R2 1 VELSPGPPKPAGR 13 1 A0A087WXE2;Q8IZ73-2;Q8IZ73 A0A087WXE2 RPUSD2 RNA pseudouridylate synthase domain-containing protein 2 1 VELS(1)PGPPKPAGR 89.624 0.012215 66488000.0 228510.0 198390.0 264410.0 218450.0 265650.0 197240.0 196530.0 184590.0 182130.0 220300.0 True False 215810.32899800752 213605.87507560704 247398.14846784077 188696.7331527306 232276.67205886796 224408.01963354906 205669.03441680718 185127.1263394806 218561.08913738764 213939.3665918601 1.0087452928180194 0.9984411867644291 1.1563937596385017 0.8820103385307025 1.085712628578501 1.048932803758648 0.9613426350334553 0.8653252054010908 1.0216029551697448 1.0 17.706842449044743 -7.3275757082310395 6.16927248471127 0.9498992494604043 1.0300728324159572 0.15467345004329858 0.07593826848483866 0.38599082846003513 28.277420767320077 0.031003569291088207 0.020812441605683924 4.703534043888844e-08 7.3275757082310395 0.08017358295555288 VENMSSNQDGNDS(ph)DEFM ddPTM_A459_Selumetinib_30min_R1 3 VENMSSNQDGNDSDEFM 17 0 Q86WR0-2;Q86WR0 Q86WR0-2 CCDC25 Coiled-coil domain-containing protein 25 1 VENMSSNQDGNDS(1)DEFM;VENMSSNQDGNDS(1)DEFM;VENMSSNQDGNDS(1)DEFM 138.24 0.00050945 7226100.0 3292.76 4571.6 4285.53 4624.6 4111.17 3550.7400000000002 4168.8 3643.26 2171.64 3332.87 True False 3369.474901404373 4036.354946720819 3703.57856473126 3817.0004244935 3739.3153993860174 3515.0227794139723 3854.3440596798637 3546.6289098236857 3685.114469689871 3760.6763294029683 0.8959757783619999 1.0733055953692288 0.9848171553012187 1.0149771185172625 0.994319923294132 0.9346783587653248 1.0249071502230997 0.943082732777148 0.9799073748723561 1.0 11.87677642777003 -6.550092507004977 24.99456015255395 0.9747063893061333 0.9984154533122709 0.02141312813433116 0.04727669099590619 702.174822099916 644910.1095886843 0.014611434721318026 0.014611691461663408 2.817782664833952e-07 6.550092507004977 0.023709064006137592 VENMSSNQDGNDS(ph)DEFM ddPTM_A459_Selumetinib_30min_R2 2 VENMSSNQDGNDSDEFM 17 0 Q86WR0-2;Q86WR0 Q86WR0-2 CCDC25 Coiled-coil domain-containing protein 25 1 VENMSSNQDGNDS(1)DEFM;VENMSSNQDGNDS(1)DEFM 126.71 0.0011484000000000002 4329900.0 22479.7 22475.2 24732.0 33162.0 27968.0 21013.3 22346.8 20911.2 17805.2 24320.3 True False 21230.368267369064 24198.975570841685 23140.77004616557 28645.27839235918 24454.409802907667 23907.691335254807 23385.97047934413 20972.048129964496 21366.737518854774 23618.109747271938 0.8989020922735498 1.0245940860545304 0.9797892504432323 1.2128522857621118 1.0354092713000593 1.0122609976446704 0.9901711326430507 0.8879647166677647 0.9046760196938617 1.0 14.52760588419296 -7.493649839554718 2.807343110220469 0.9228655470423726 1.0340083863312428 0.22330959947176088 0.0785270819784465 0.38274762508166826 6.036893135223157 0.041915324379534116 0.023902094749397595 3.208855499251796e-08 7.493649839554718 0.11114283928887025 VEPADSVESSPPSITHS(ph)PQNELK ddPTM_A459_Selumetinib_30min_R2 2 VEPADSVESSPPSITHSPQNELK 23 0 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 VEPADSVESSPPSIT(0.004)HS(0.996)PQNELK;VEPADSVESSPPSIT(0.004)HS(0.996)PQNELK 135.69 3.5974e-06 14202600.0 25489.0 22365.6 33323.0 41861.0 39882.0 31136.3 28593.0 30223.0 26029.3 40062.0 True False 24072.423420551426 24080.969603261226 31179.03445933915 36159.45958574718 34871.666610396285 35425.04269781014 29922.631155954638 30310.94392631301 31235.88731940818 38905.30596642346 0.6187439687873605 0.6189636350384671 0.8014082831336082 0.9294223162504869 0.8963216133164886 0.9105452795663167 0.7691144025901978 0.7790953746122017 0.8028695969224805 1.0 15.247679305183269 -5.334563992740223 3.574296430159171 0.8593583304561859 0.6146213905433372 0.6732522866885742 0.06851735925443955 0.14150748991810178 3.4885550328956505 0.019328747333877957 0.046860995222883894 4.628454590623511e-06 5.334563992740223 -0.24473693991284873 VEPAS(ph)PPYYSEK ddPTM_A459_Selumetinib_30min_R2 1 VEPASPPYYSEK 12 0 E7EU07;E7EUD1;A0A499FIV4;E9PFX5;A0A494C0D9;E9PFV2;P37231-3;P37231-2;P37231 E7EU07 PPARG Peroxisome proliferator-activated receptor gamma 1 VEPAS(0.999)PPYYS(0.001)EK 136.3 0.0014186 3024200.0 22427.0 15869.0 20273.0 18465.0 28547.0 17394.0 14969.0 16846.0 15332.0 19184.0 True False 21180.59712239427 17086.10127312268 18968.65725157346 15950.035146098307 24960.67064658198 19789.865612989022 15665.088160510793 16895.019070994567 18398.82841187302 18630.108073982014 1.1369014628516383 0.9171230357479447 1.0181721531752275 0.856142921058704 1.3398027830789103 1.0622517880412445 0.8408479488311699 0.9068664016280938 0.987585704753265 1.0 14.185348422983356 -7.23676964096232 23.97136103667305 0.9260638736336698 1.0510192609533466 0.17495574380837398 0.1283602572897416 838.263356496188 814533.4940230489 0.05039097034092223 0.0390112025103151 5.797361192659007e-08 7.23676964096232 0.12495538731967681 VEPEVLSTDTQT(ph)SPEPGTR ddPTM_A459_Selumetinib_30min_R1 1 VEPEVLSTDTQTSPEPGTR 19 0 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 VEPEVLSTDTQT(0.5)S(0.5)PEPGTR 202.79 2.8114e-15 5872600.0 1917.0 2296.2 2173.7 2467.5 2038.7 1968.4 2049.2 1828.1 1194.8 1543.6 True False 1961.6623701673318 2027.3598365255802 1878.5234792794222 2036.5974457115663 1854.2999449617196 1948.5996831642015 1894.6271941796144 1779.61284949432 2027.4883352606598 1741.7360959372622 1.1262684253619506 1.1639879550378258 1.078535079832833 1.1692916340552921 1.0646273848759416 1.1187686169618147 1.0877808633575332 1.0217465514123572 1.1640617312748684 1.0 10.76631033114476 -14.522878744993019 0.08239304395625421 0.6564989499085506 1.20847439212137 0.3657403491791308 0.04506861675986575 246.66901144513142 1.4274721197196403 15.373275916743856 1.331849226326884 3.0000000019847277e-15 14.522878744993019 0.5519754422128195 VEPEVLSTDTQTS(ph)PEPGTR ddPTM_A459_Selumetinib_30min_R2 2 VEPEVLSTDTQTSPEPGTR 19 0 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 VEPEVLSTDTQT(0.299)S(0.699)PEPGT(0.001)R;VEPEVLS(0.002)T(0.002)DT(0.071)QT(0.223)S(0.702)PEPGT(0.001)R 130.95 0.0002773 12980900.0 53121.0 40909.0 55519.0 65458.0 58577.0 46540.0 54296.0 56897.0 44283.0 52382.0 True False 50168.74748021157 44046.58875683254 51946.96798451672 56542.50747865166 51218.03357497577 52950.4625519437 56820.87158548294 57062.56085019457 53140.83737040004 50869.59555521922 0.9862226528959351 0.8658725959206759 1.021179103500597 1.1115187148927588 1.0068496322007972 1.0409059080185863 1.1169908265498905 1.1217419802021593 1.0446483167477787 1.0 15.634516003476763 -5.465075963545384 5.658951096116729 1.0673652409536762 0.9278653506936638 0.5481078282848865 0.04907984445736232 0.14466080659021846 9.79365064796262 0.012843986094722747 0.02676114914388019 3.4270783740973926e-06 5.465075963545384 -0.13949989026001242 VEPGLGADNS(ph)VVR ddPTM_A459_Selumetinib_30min_R1 1 VEPGLGADNSVVR 13 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 VEPGLGADNS(1)VVR 90.853 0.02057 2157000.0 1149.4 1334.2 1329.4 1392.0 1354.4 1275.8 1303.6 1477.9 645.16 1275.8 True False 1176.178783656928 1177.9912437472472 1148.874781871492 1148.9133310761918 1231.894759138742 1262.9666103337179 1205.268402465618 1438.7012911042366 1094.7893993779446 1439.5613573443643 0.8170397028624663 0.8182987392217519 0.7980728129510801 0.7980995913891809 0.8557431420716127 0.8773273913545303 0.8372469824343166 0.9994025497866139 0.7605020750192691 1.0 10.49141356578292 -14.522878733346388 0.08864099823498685 1.5129317840925478 0.7104426673676699 0.41409847584469384 0.05972103723640376 199.21381550247878 1.2256621443700626 19.34252059681202 1.4010526506349812 3.000000082436801e-15 14.522878733346388 -0.8024891167248779 VEPGLGADNSVVR ddPTM_A459_Selumetinib_30min_R2 1 VEPGLGADNSVVR 13 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 144.17 0.0094664 3803200.0 23019.0 17919.0 15353.0 20422.0 15907.0 16854.0 16678.0 19959.0 12905.0 18438.0 False True 21739.696132358033 19293.329681333744 14365.204695082493 17640.488370085008 13908.620449615697 19175.485514620967 17453.56004683005 20017.077385609668 15486.360595827126 17905.647032322784 1.214125135668883 1.0774997209822104 0.8022723037682369 0.9851913387011864 0.7767728485046218 1.0709183242585931 0.9747517090738671 1.1179198020309116 0.8648869581686477 1.0 14.12812703188325 -4.993279641357082 5.179556636487817 0.9524676831819658 1.1903427403504527 0.39611787110538776 0.1035296536023395 0.16189012505897862 13.727835064954657 0.02589409383623161 0.09616763985858279 1.0155945429748354e-05 4.993279641357082 0.2378750571684869 VEPGSLES(ph)SPGLGR ddPTM_A459_Selumetinib_30min_R1 3 VEPGSLESSPGLGR 14 0 Q92615;H0Y4V9 Q92615 LARP4B La-related protein 4B 1 VEPGS(0.002)LES(0.899)S(0.099)PGLGR;VEPGSLES(0.5)S(0.5)PGLGR;VEPGS(0.085)LES(0.458)S(0.458)PGLGR 171.36 0.00014246 24567100.0 5109.9 6411.5 6331.6 6606.1 7314.5 5333.2 6574.900000000001 5139.3 2952.41 4990.6 True False 5228.950727865439 5660.838599374514 5471.803496989275 5452.468646855193 6652.904766479864 5279.552850158158 6078.949999517641 5002.989069200895 5010.024134505295 5631.192122560576 0.928569051465388 1.0052646892822505 0.9716954026603475 0.9682618756711652 1.181438072380081 0.9375550922878969 1.079513869747613 0.8884422623687667 0.8896915653851235 1.0 12.459224657632847 -7.777381370529256 24.999250012187435 0.9168001654509343 1.0108119035926284 0.20232668008580557 0.07602391289205225 362.63597475839197 568655.1814447661 0.04041835820911607 0.019514501646716063 1.6696238101037113e-08 7.777381370529256 0.09401173814169406 VEPGSLES(ph)SPGLGR ddPTM_A459_Selumetinib_30min_R2 2 VEPGSLESSPGLGR 14 0 Q92615;H0Y4V9 Q92615 LARP4B La-related protein 4B 1 VEPGSLES(0.852)S(0.148)PGLGR;VEPGS(0.002)LES(0.612)S(0.386)PGLGR 157.09 0.00031595 31512000.0 53425.0 55010.0 67536.0 69654.0 71187.0 48386.0 55243.0 62798.0 47759.0 62895.0 True False 50455.85237722003 59229.09011497125 63190.80728763697 60167.005040147895 62243.852640145466 55050.732295624155 57811.908961927795 62980.73178323147 57312.13449795485 61079.057929164905 0.8260745022579604 0.9697119131022107 1.0345740329020974 0.9850676660718188 1.0190702795765352 0.9013029041716398 0.9465095062365547 1.0311346297493977 0.9383270869112182 1.0 15.898390190024042 -4.7657575859267975 5.192418333426475 0.9817174531761986 0.8176366293692214 0.5661023306042687 0.04071146531147388 0.11933267451068005 9.097483825626464 0.010325599925523116 0.07076393543761975 1.7149142695912372e-05 4.7657575859267975 -0.1640808238069772 VEPGSLESS(ph)PGLGR ddPTM_A459_Selumetinib_30min_R1 1 VEPGSLESSPGLGR 14 0 Q92615;H0Y4V9 Q92615 LARP4B La-related protein 4B 1 VEPGSLES(0.144)S(0.855)PGLGR 185.66 7.9994e-05 15453000.0 3178.4 3848.9 4040.2 4151.4 4064.7 3030.3 3550.9 3310.8 1526.5 2796.4 True False 3252.450535910195 3398.268998694935 3491.563031230033 3426.435921429384 3697.048602681072 2999.8179332922587 3283.052754154011 3222.986829005958 2590.3590088511855 3155.3451792426567 1.0307748760124067 1.0769880332111825 1.1065550147093812 1.0859147658297703 1.1716780233750637 0.9507099106070773 1.0404734086626954 1.0214371632645074 0.8209431493871999 1.0 11.623582122244512 -7.523384768452275 1.1261019982493687 0.9291872534630176 1.086404767987083 0.42788776603533607 0.06863505320408728 0.478746443704012 1.129396825365666 0.05285827200882406 0.02439194629277826 2.996506551373754e-08 7.523384768452275 0.1572175145240654 VEPSS(ph)QSPGRSPR ddPTM_A459_Selumetinib_30min_R1 1 VEPSSQSPGRSPR 13 1 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 VEPS(0.238)S(0.517)QS(0.048)PGRS(0.198)PR 137.39 0.004952399999999999 14087000.0 3634.1 3635.2 4686.1 5402.5 4201.3 3859.2 4480.3 3294.9 2020.2 2504.3 True False 3718.767459272353 3209.5890940413688 4049.753358904769 4459.054792485003 3821.2931567997616 3820.379951873242 4142.347363889775 3207.50854865644 3428.1318504298515 2825.751298947712 1.316027868644064 1.135835660851185 1.4331598681075954 1.578006809780295 1.3523105017142811 1.3519873292798 1.4659277925245415 1.1350993804199583 1.2131753603745883 1.0 11.464418780920017 -7.77591152421626 24.73072346551138 1.1306028388588543 1.3750410552882497 0.5052454146530212 0.11767700800464084 203.71355904972015 348110.19737656345 0.06822730870985746 0.03301298455612158 1.6752841352086867e-08 7.77591152421626 0.24443821642939545 VEPSSQS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 VEPSSQSPGR 10 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 VEPSSQS(1)PGR 147.33 0.00082892 25427000.0 2962.0 3348.0 2137.4 2551.1 2765.7 2525.9 2542.1 2453.3 1636.3 2539.3 True False 3031.0088369512946 2956.0146035570256 1847.1528198977944 2105.5982750779244 2515.542923323994 2500.491739333701 2350.3473503435494 2388.230514558511 2776.6815893764797 2865.2438898765836 1.0578536953382531 1.0316799257477351 0.6446755986197593 0.7348757578778469 0.8779507155435718 0.8726976953579355 0.8202957377023802 0.8335173571075587 0.969090833484364 1.0 11.484442231232372 -8.351140429730073 4.441911675273215 0.996152982643485 0.8534731377152416 0.1580735513148266 0.11570624562829619 0.44068536972164213 14.41570307819582 0.1189405112739523 0.03145016547965736 4.455121681198284e-09 8.351140429730073 -0.14267984492824337 VEPSSQS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 2 VEPSSQSPGR 10 0 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 VEPSS(0.001)QS(0.999)PGR;VEPS(0.001)S(0.006)QS(0.993)PGR 109.16 0.01024 81055000.0 95870.0 94281.0 112758.0 120982.0 123451.0 116523.0 88026.0 106460.0 94756.0 100055.0 True False 90541.9291980174 101512.04953880406 105503.27304162772 104504.04289440904 107941.98171405718 132572.98555952174 92119.38342020994 106769.78097459828 113709.84770385076 97166.1521758899 0.9318258176377989 1.0447264532514082 1.085802727380271 1.0755190007445814 1.1109010627349007 1.3643947258458735 0.9480604238959229 1.0988371833570596 1.1702619189655004 1.0 16.568166218150786 -4.422709008932828 1.0281438811873158 1.1181419249364524 0.6996914818121297 0.21175189854576226 0.1040345694364065 5.427640621572041 2.835814920070299 0.03329953839713592 2.9761618629270843 3.7782526103293544e-05 4.422709008932828 -0.41845044312432267 VEPSSQSPGRS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 VEPSSQSPGRSPR 13 1 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 VEPSS(0.05)QS(0.012)PGRS(0.938)PR;VEPS(0.007)S(0.074)QS(0.103)PGRS(0.816)PR;VEPS(0.019)S(0.164)QS(0.067)PGRS(0.749)PR 179.55 0.00052125 110090000.0 11112.3 11166.800000000001 15092.7 15602.6 14330.2 10928.1 10674.5 10709.7 6898.1 8899.6 True False 11371.194969228178 9859.385864695521 13043.194238266795 12877.8988070757 13034.035940202299 10818.173235920913 9869.313870910752 10425.64396599164 11705.571882709708 10041.950349444982 1.1323691686900905 0.9818198180237417 1.2988706162033246 1.282410125418262 1.2979586122851812 1.0772980207494087 0.9828084712105979 1.0382090732571552 1.1656671737434625 1.0 13.293751876548308 -6.927496155413362 8.379494074505685 1.0470588405533126 1.1965392422328192 0.3529485105923481 0.09942609579215092 0.34285509416341425 35.388291348625614 0.03839629868834937 0.03385128870379938 1.1816907734017328e-07 6.927496155413362 0.1494804016795066 VEPSSQSPGRS(ph)PR ddPTM_A459_Selumetinib_30min_R2 5 VEPSSQSPGRSPR 13 1 X6RM00;G8JLD3;X6RLX0;Q8IUD2-5;Q8IUD2-4;Q8IUD2-2;Q8IUD2-3;Q8IUD2;K7EKH8;K7EIZ7 X6RM00 ERC1 ELKS/Rab6-interacting/CAST family member 1 1 VEPSSQSPGRS(1)PR;VEPSSQSPGRS(1)PR;VEPSSQSPGRS(1)PR;VEPSSQS(0.001)PGRS(0.999)PR;VEPSSQSPGRS(1)PR 142.57 0.00042263 321863000.0 326061.0 298185.1 353926.0 353569.6 357721.0 262193.9 229583.2 243383.0 217186.3 337772.8 True False 307939.83494560124 321054.93835378427 331154.78648549283 305412.8105384201 312780.8899136848 298308.7297657513 240259.27371048022 244091.20423577508 260629.62869225023 328020.42162486986 0.9387825106138264 0.9787650926226433 1.0095553954997578 0.9310786475596198 0.953540905667717 0.9094212131307562 0.7324521824596796 0.7441341701429864 0.7945530567920281 1.0 18.32342611019417 -7.059538400067689 4.300125285583672 0.7970572111941514 0.9622699390525895 0.45919543708187005 0.07246943132655967 0.1708105895218103 6.3649713100211605 0.027108667831380467 0.021290989184616825 8.718898058848271e-08 7.059538400067689 0.1652127278584381 VEPVGEDLGS(ph)PPPPADFAPEDYSSFQHIR ddPTM_A459_Selumetinib_30min_R1 1 VEPVGEDLGSPPPPADFAPEDYSSFQHIR 29 0 K7ER53;O95644-8;O95644-11;O95644-3;O95644-10;O95644-2;O95644-5;O95644-4;O95644-6;O95644 K7ER53 NFATC1 Nuclear factor of activated T-cells, cytoplasmic 1 1 VEPVGEDLGS(1)PPPPADFAPEDYSSFQHIR 63.932 0.00052576 5706100.0 444.31 724.71 355.04 451.42 524.3 530.36 636.0 476.04 232.03 337.37 True False 454.66155852323783 639.8606162914617 306.8275180951215 372.5879712028839 476.877157572683 525.0250599283514 588.0260079534622 463.4138728041551 393.7379631993061 380.6747257620851 1.194357092168481 1.6808592033802718 0.8060096910318213 0.9787567862746548 1.2527155739536087 1.3791960022491294 1.5446941132650032 1.217348674452794 1.0343160093202124 1.0 8.572414977620461 -8.245701594076872 4.371055530848044 1.0092438699906343 1.26168784008727 0.14219475527865955 0.2372374656483919 0.4202184706633235 19.922752092295806 0.2086114310215209 0.06473707207739741 5.679347021651927e-09 8.245701594076872 0.25244397009663566 VEQALSEVASS(ph)LQSSAPK ddPTM_A459_Selumetinib_30min_R2 1 VEQALSEVASSLQSSAPK 18 0 Q86TV6;Q86TV6-2;H0YK02;H0YJS2;A0A0C4DGK5 Q86TV6 TTC7B Tetratricopeptide repeat protein 7B 1 VEQALSEVAS(0.418)S(0.582)LQSSAPK 211.16 1.8959999999999997e-30 0.0 13779.0 14450.0 13597.0 15078.0 15113.0 9399.0 12898.0 15118.0 10148.0 11806.0 True False 13013.218341707337 15558.268535926822 12722.183823294245 13024.350388999203 13214.369828065772 10693.626934372987 13497.78255690214 15161.990877080378 12177.88355881081 11465.13010432818 1.1350257889175406 1.357007586861439 1.109641470051135 1.1359967371048327 1.1525704207296557 0.9327087296057858 1.1772899595623967 1.3224438570790054 1.0621670620391443 1.0 13.4849651060167 -5.299695369761197 24.710472195314573 1.1214094219432011 1.2460167845586438 0.1857378951886519 0.1110655601364778 740.8558718317156 478535.53715172876 0.029279048788648825 0.060951639786136935 5.01538908244677e-06 5.299695369761197 0.1246073626154427 VEQAT(ph)KPSFESGR ddPTM_A459_Selumetinib_30min_R1 1 VEQATKPSFESGR 13 1 H3BT71;H0Y6E7;P38159;P38159-2 H3BT71;P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 VEQAT(0.97)KPS(0.029)FESGR 159.12 0.0037763000000000007 17717000.0 2095.6 2640.9 2212.4 2033.2 2034.6 2049.7 2155.8 1996.8 1209.9 1599.7 True False 2144.4234026722256 2331.702200278899 1911.968231843305 1678.1397878908851 1850.5707892378048 2029.0818789786958 1993.186270355464 1943.8383774794904 2053.111932400296 1805.0370773975376 1.1880218027233034 1.2917752380137784 1.0592404199253005 0.9296982366203745 1.0252259149745093 1.124121994161018 1.1042356388762915 1.076896647620155 1.1374347696837492 1.0 10.817812756582383 -5.272156404153266 24.29342906673861 1.058240678031072 1.2398985180343398 0.5752635243154627 0.0628204866736425 318.2931122244179 721510.3736825349 0.017642667297361088 0.03735310722128007 5.3437187932587635e-06 5.272156404153266 0.1816578400032678 VEQATKPS(ph)FESGR ddPTM_A459_Selumetinib_30min_R1 3 VEQATKPSFESGR 13 1 H3BT71;H0Y6E7;P38159;P38159-2 H3BT71;P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 VEQATKPS(1)FESGR;VEQATKPS(0.997)FES(0.003)GR;VEQATKPS(0.951)FES(0.049)GR 193.98 0.00048207 90977000.0 8949.8 10814.3 7949.0 8455.4 8127.900000000001 8527.3 9086.0 8661.1 4255.2 7867.799999999999 True False 9158.312926720691 9548.156728568325 6869.5694607315245 6978.823117515541 7392.7328800972955 8441.52310416892 8400.635704819433 8431.37949278227 7220.763612488417 8877.708768861881 1.0316077227992673 1.0755203822475012 0.7737998215064449 0.786106336580156 0.8327298261942243 0.9508673154245766 0.9462616902104564 0.9497247220313095 0.8133589195688513 1.0 13.115971666831488 -5.2430587930348596 24.74887152684593 0.8794369909030734 1.0535640923908083 0.4558729059665084 0.07511691016590309 676.8088988832362 911297.5774679066 0.020328221975917094 0.0535467464614276 5.7140127743599405e-06 5.2430587930348596 0.17412710148773491 VEQATKPS(ph)FESGR ddPTM_A459_Selumetinib_30min_R2 2 VEQATKPSFESGR 13 1 H3BT71;H0Y6E7;P38159;P38159-2 H3BT71;P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 VEQAT(0.01)KPS(0.99)FESGR;VEQAT(0.007)KPS(0.876)FES(0.116)GR 115.1 0.019318 182290000.0 593320.0 516630.0 545490.0 601680.0 542570.0 564420.0 472940.0 559060.0 485020.0 547530.0 True False 560345.6496481459 556253.8597727255 510393.76728460565 519730.14604410593 474407.50596265704 642163.7317053735 494932.64711283165 560686.7720426344 582037.5525910949 531721.3862462133 1.0538331993828778 1.0461378348907568 0.9598894843929938 0.9774482642371002 0.892210691978793 1.2077071720564947 0.9308120002599506 1.0544747428740975 1.0946288181111126 1.0 19.020310968337093 VEQFPDASGSLK ddPTM_A459_Selumetinib_30min_R1 2 VEQFPDASGSLK 12 0 Q96L96 Q96L96 ALPK3 Alpha-protein kinase 3 0 ; 105.2 0.013237 26988000.0 3964.3 4622.1 5076.6 6058.6 5210.8 4626.5 5193.6 4535.7 2755.3 4088.2 False True 4056.660476814998 4080.942383244009 4387.22560376773 5000.57924400734 4739.48406004146 4579.961610525897 4801.842570608649 4415.398501970019 4675.542860850097 4612.960292440216 0.8794050283639142 0.8846688730297363 0.95106511342783 1.0840282436860251 1.0274278900272766 0.9928465280812416 1.0409460013080918 0.9571724493718353 1.0135666826598186 1.0 12.171477158651145 -5.478086657657063 4.003452987543092 1.0156814484615957 0.8852243805289297 0.7435698885957451 0.03160220507592363 0.10990899168111318 3.6861691261865226 0.008866989719725406 0.018739412614265684 3.3259318214997735e-06 5.478086657657063 -0.13045706793266598 VEQMPQAS(ph)PGLAPR ddPTM_A459_Selumetinib_30min_R1 1 VEQMPQASPGLAPR 14 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 VEQMPQAS(1)PGLAPR 137.91 0.00058312 40179000.0 2065.8 2657.5 2685.7 2984.5 2760.6 2544.7 2809.2 2441.5 1578.7 2009.6 True False 2113.929120652932 2346.358664561768 2320.9966914941083 2463.313101003515 2510.904217423516 2519.1026284027366 2597.2997823001047 2376.7434888903144 2678.9385963140326 2267.55173516165 0.9322517708740319 1.0347541924526367 1.023569454007914 1.0863315984399842 1.1073194840445473 1.110935018302087 1.145420297153638 1.0481540297561855 1.1814233628160442 1.0 11.146919751495133 -4.466586703874615 0.7420309004187168 1.1051259151707684 0.7630667335868888 0.5092373043615628 0.0490878153872472 3.1677683974953084 0.9610384515288809 0.018143239084188835 1.0050339976601272 3.415177622322007e-05 4.466586703874615 -0.3420591815838796 VEQMPQAS(ph)PGLAPR ddPTM_A459_Selumetinib_30min_R2 4 VEQMPQASPGLAPR 14 0 Q8N3F8;H0Y6J8 Q8N3F8 MICALL1 MICAL-like protein 1 1 VEQMPQAS(1)PGLAPR;VEQMPQAS(1)PGLAPR;VEQMPQAS(1)PGLAPR;VEQMPQAS(1)PGLAPR 199.61 7.7435e-05 186624800.0 344992.0 336682.0 358871.0 390393.0 397242.0 302669.0 287752.0 290247.0 256536.3 312675.0 True False 325818.7257523983 362504.426796741 335781.63056920207 337220.7999345112 347336.90857146145 344358.9073943756 301133.03816977114 291091.57071702246 307850.72822311416 303647.2603227857 1.073017175936459 1.193834011251702 1.1058279604178105 1.1105675696729023 1.1438828995270116 1.1340754631815622 0.9917199247892378 0.9586504103728247 1.013843259760882 1.0 18.2120368268734 -7.266133465557183 12.139825465450246 0.9875876281690649 1.1289939650159992 0.8130896973978695 0.03187344403819002 0.14847715707652595 373.65555255879804 0.012291017762079583 0.00873604065289605 5.418343505545639e-08 7.266133465557183 0.14140633684693438 VERLS(ph)SGPEQITLEASSTEGHPGAPSPQHTDQTEAFQK ddPTM_A459_Selumetinib_30min_R1 1 VERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQK 38 1 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 VERLS(0.5)S(0.5)GPEQIT(0.001)LEASSTEGHPGAPSPQHTDQTEAFQK 93.191 1.2015000000000002e-10 8542700.0 950.08 931.47 671.02 703.33 1591.4 660.93 1280.1 884.46 122.2 442.12 True False 972.2150154661334 822.4130593713451 579.8991696490212 580.5066186392365 1447.4581509844897 654.2816442764254 1183.5410263855774 861.0012476690258 207.3644748651262 498.8704086134895 1.9488328004224797 1.6485504956228567 1.1624244686325151 1.1636421175043006 2.901471255846604 1.3115262660995874 2.3724418324891086 1.7259016225516495 0.4156680197597895 1.0 8.962521285633985 -8.248786429196587 22.765857127022855 0.7078342773208915 1.7754811463478484 0.3953824555599389 0.5299997907528612 204.81747880055528 368523.77991882333 0.3638505244758419 0.1349192166802468 5.639149012327962e-09 8.248786429196587 1.067646869026957 VERLS(ph)SGPEQITLEASSTEGHPGAPSPQHTDQTEAFQK ddPTM_A459_Selumetinib_30min_R2 1 VERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQK 38 1 Q6P996-4;H3BND4;Q6P996-3;Q6P996-5;Q6P996 Q6P996-4 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 VERLS(0.483)S(0.483)GPEQIT(0.009)LEAS(0.008)S(0.008)T(0.008)EGHPGAPS(0.001)PQHTDQTEAFQK 52.276 0.001177 7319200.0 3840.6 2606.7 6256.3 8241.2 10998.0 7658.5 4484.6 6694.4 7086.9 7546.9 True False 3627.1548271399392 2806.62550813844 5853.776469344398 7118.734343137043 9616.332916632524 8713.388858058897 4693.142786066314 6713.879595682417 8504.478024530583 7329.0013877989395 0.4949043717167659 0.3829478751103541 0.7987140620671128 0.9713102735917144 1.3120932044905125 1.1888916916518308 0.6403522850847445 0.916070176608159 1.1603870124364466 1.0 12.839400922173084 -5.472449761307941 2.6377216352858435 1.0258895636147278 0.4346266815910346 0.6439051723848124 0.17333542972847463 0.18855874943025777 2.5649094298196973 0.053302660624588556 0.12722889649752683 3.369381901140689e-06 5.472449761307941 -0.5912628820236931 VERPPS(ph)PFSMAPQASLPPVPPR ddPTM_A459_Selumetinib_30min_R1 1 VERPPSPFSMAPQASLPPVPPR 22 1 A0A1B0GW38;A0A0U1RQX8;P22681 A0A1B0GW38 CBL E3 ubiquitin-protein ligase CBL 1 VERPPS(0.996)PFS(0.004)MAPQASLPPVPPR 85.177 0.00035081 42741000.0 880.96 879.57 1160.4 1240.6 951.77 1146.0 1008.3 734.77 551.6 572.38 True False 901.4846539502412 776.5895354990007 1002.8240536209422 1023.952498946209 865.6825715486416 1134.4722804847474 932.2431192130122 715.2815127306724 936.0249127299799 645.850548453337 1.3958099998662057 1.2024291647018857 1.5527184362117126 1.585432576310942 1.3403759950684437 1.7565554185895589 1.4434347411262858 1.1075031436353295 1.449290265327704 1.0 9.335056549817743 -10.625766692813288 5.0589145266301925 0.9999876647168222 1.4261499617111453 0.3440961315141944 0.17642477421274866 2.5510203508437547e-05 4.5235859688779955e-06 0.17753803281870656 0.04305805262096549 2.367191033835375e-11 10.625766692813288 0.42616229699432306 VERPPS(ph)PFSMAPQASLPPVPPR ddPTM_A459_Selumetinib_30min_R2 2 VERPPSPFSMAPQASLPPVPPR 22 1 A0A1B0GW38;A0A0U1RQX8;P22681 A0A1B0GW38 CBL E3 ubiquitin-protein ligase CBL 1 VERPPS(0.988)PFS(0.012)MAPQASLPPVPPR;VERPPS(0.807)PFS(0.185)MAPQAS(0.008)LPPVPPR 85.177 0.00035081 33696700.0 93126.0 85007.0 99663.0 94207.0 111873.0 70476.0 77002.0 89839.0 70512.0 98008.0 True False 87950.42973291509 91526.76355941384 93250.79108486982 81375.84408386057 97818.51358269043 80183.42928256952 80582.74557656834 90100.41661635296 84616.37026989255 95178.25438463475 0.9240601259347482 0.9616352406457835 0.9797489110067552 0.8549835738214339 1.0277401515201765 0.8424553465598551 0.8466508037741165 0.9466491815687098 0.8890304914391529 1.0 16.538344374563458 -6.7816176590600294 24.999319229293974 0.8979786249481688 0.9467151511601251 0.1173459673317443 0.059482329965946934 495.3120782758147 613649.0992843619 0.02021913794999799 0.017853021634126047 1.6534167804170853e-07 6.7816176590600294 0.04873652621195623 VES(ph)VEPSENEASK ddPTM_A459_Selumetinib_30min_R1 2 VESVEPSENEASK 13 0 Q9H307 Q9H307 PNN Pinin 1 VES(1)VEPSENEASK;VES(0.956)VEPS(0.044)ENEASK 139.77 0.0013791 0.0 1721.9499999999998 1852.8200000000002 1315.6 992.2 1234.26 1464.96 1914.48 2074.68 1084.15 1947.28 True False 1762.0680846685636 1635.8909730473508 1136.9487460735181 818.9308959007167 1122.6214009263012 1450.223832477255 1770.0692322433085 2019.6527468896002 1839.723366816912 2197.232356113444 0.8019489062073448 0.744523431259215 0.5174458417700531 0.3727101931765085 0.5109252090716708 0.6600229731927265 0.8055903725058375 0.9191803230415039 0.8372912230689572 1.0 11.1014717266979 -7.325150350692371 2.226318813957673 0.9076751498310034 0.5827262328990296 0.5963299102034542 0.119764554199423 0.25522300714232954 2.4722520244574766 0.0686296913455686 0.042479973733331865 4.729874845875494e-08 7.325150350692371 -0.3249489169319738 VES(ph)VEPSENEASK ddPTM_A459_Selumetinib_30min_R2 1 VESVEPSENEASK 13 0 Q9H307 Q9H307 PNN Pinin 1 VES(0.999)VEPS(0.001)ENEASK 134.37 0.0012283 7442500.0 29299.0 19682.0 24713.0 28406.0 27192.0 27310.0 46054.0 38195.0 35900.0 21880.0 True False 27670.67887318986 21191.546112395266 23122.992485479954 24537.0537969168 23775.89786043566 31071.704604503295 48195.60225426974 38306.141126477356 43081.003129809666 21248.26754893279 1.3022557631800735 0.9973305382941504 1.0882295430547384 1.1547790303567216 1.1189570069974868 1.462317082225553 2.2682132622473685 1.8027889115318163 2.0275066205090893 1.0 14.375057597249052 -6.986633214918906 4.425676550692035 1.8478327824002658 1.1303521807008643 0.47518426112059686 0.3138389614084033 0.14917212470428987 7.215750405175724 0.10997232370700907 0.09204148674890732 1.0312567045928425e-07 6.986633214918906 -0.7174806016994015 VESEES(ph)GDEEGKK ddPTM_A459_Selumetinib_30min_R1 1 VESEESGDEEGKK 13 1 B5MBZ8;Q15435-3;Q15435;H7C118;C9JRC4;C9JD73;H7C003 B5MBZ8 PPP1R7 Protein phosphatase 1 regulatory subunit 7 1 VESEES(1)GDEEGKK 148.52 0.0009772 6755500.0 2029.6 2405.6 1984.0 1865.7 1674.2 2274.3 2102.5 2190.1 1722.7 2187.4 True False 2076.8857310858707 2123.9512336669 1714.5836973319097 1539.8905185264732 1522.7689056040172 2251.422606899179 1943.9067322675396 2132.0114335526005 2923.2960789701556 2468.1740970803116 0.8414664644372901 0.8605354201631867 0.6946769676256428 0.6238986627191586 0.6169617076061826 0.9121814419665389 0.7875889851396844 0.8638010730582703 1.1843962232762362 1.0 11.26922844581711 -8.063874341455724 3.468510740595854 1.089436416838842 0.7599190219645959 0.6205688362377195 0.10134690411650835 0.17147951803207168 3.91538899918675 0.08252634812282113 0.028936468517365505 8.632282776672201e-09 8.063874341455724 -0.32951739487424603 VESEES(ph)GDEEGKK ddPTM_A459_Selumetinib_30min_R2 1 VESEESGDEEGKK 13 1 B5MBZ8;Q15435-3;Q15435;H7C118;C9JRC4;C9JD73;H7C003 B5MBZ8 PPP1R7 Protein phosphatase 1 regulatory subunit 7 1 VESEES(1)GDEEGKK 201.76 0.00015966 4158800.0 81899.0 57177.0 48250.0 59360.0 52797.0 52448.0 92692.0 92343.0 54369.0 65637.0 True False 77347.38144767321 61562.29204696804 45145.64753062788 51275.06559828845 46164.16884883136 59672.235924459455 97002.36166571346 92611.7028417934 65244.319196786084 63741.88926459325 1.2134466414480345 0.9658058893018109 0.708257129675398 0.8044170982357475 0.7242359676099874 0.936154177620299 1.5217992874835515 1.4529174442470831 1.0235705271608162 1.0 15.95995415976133 -7.118955011733422 6.593110425854719 1.2854898391263478 0.8697747236996948 0.42260030893692735 0.20331115860780402 0.22037317530010914 11.085771650211665 0.08013265823375944 0.0620137915832793 7.604050426956669e-08 7.118955011733422 -0.41571511542665307 VESGYFS(ph)LEK ddPTM_A459_Selumetinib_30min_R1 2 VESGYFSLEK 10 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 VESGYFS(1)LEK;VESGYFS(1)LEK 166.29 0.00033071 54789000.0 4833.5 5670.1 5981.7 6136.3 5556.5 4822.8 6059.8 5145.2 3225.7 5306.2 True False 4946.111145646217 5006.242056042023 5169.417995126149 5064.710397616977 5053.915556079755 4774.287010752042 5602.704407227033 5008.732582034996 5473.777304193434 5987.3024567649045 0.8261000978926208 0.8361431700156712 0.8633968356292662 0.8459085596877584 0.8441056039134054 0.7974020095406561 0.9357643859960133 0.8365591379763608 0.9142309652335584 1.0 12.547690436455023 -8.937122724207391 0.5356250639906458 1.0067041513326027 0.8378743567435181 0.6785491521384017 0.03302941916961056 0.9434400983486322 0.5166950388971914 0.04459759459946885 0.015553011510979611 1.1557855907619589e-09 8.937122724207391 -0.16882979458908465 VESGYFS(ph)LEK ddPTM_A459_Selumetinib_30min_R2 4 VESGYFSLEK 10 0 A0A494BZV2;Q6WCQ1-2;Q6WCQ1;J3KSW8;Q6WCQ1-3;A0A1W2PPU9 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 1 VESGYFS(1)LEK;VESGYFS(1)LEK;VESGYFS(1)LEK;VESGYFS(1)LEK 147.26 0.00083152 44774500.0 151324.0 114573.0 114898.0 117863.0 108443.0 77654.0 100506.0 91308.0 68043.5 89799.0 True False 142914.01787796797 123360.38068973996 107505.58777148351 101809.85607498416 94819.42084727965 88350.13362717311 105179.7281488607 91573.69116314691 81654.1012942398 87206.26954417786 1.6388043958877188 1.4145815585798769 1.232773610583379 1.167460282467515 1.0873005042285984 1.0131167642988763 1.2061028260769444 1.0500815095267497 0.9363329233212367 1.0 16.412144238349214 -1.522878745280343 0.4445084388610113 1.0227012401864202 15.031370869920119 0.9080423270580028 0.06169856971973186 24.36318733017963 0.2970624419017546 0.04075025157844401 308.6655955439162 0.029999999999999628 1.522878745280343 14.0086696297337 VESVEPS(ph)ENEASK ddPTM_A459_Selumetinib_30min_R2 1 VESVEPSENEASK 13 0 Q9H307 Q9H307 PNN Pinin 1 VESVEPS(0.978)ENEAS(0.022)K 158.52 0.00036458 2752500.0 16434.0 10351.0 12841.0 18088.0 17999.0 18011.0 24609.0 22505.0 18495.0 12540.0 True False 15520.66407051443 11144.888416289175 12014.82404022368 15624.383196459597 15737.804706898414 20491.851762420672 25753.367261808417 22570.485824096697 22194.516793477138 12177.937617167145 1.274490357762637 0.9151704308764328 0.9866058127351939 1.2830073274832698 1.2923210154002556 1.6827029671701936 2.114756050770378 1.8533914800383982 1.8225185159587038 1.0 13.571982207258534 -6.612219073257201 2.039108445121208 1.784614441824431 1.0854318015081905 0.46508922796240015 0.2904226756280235 0.24570726998419395 2.08378844504278 0.10639511301114049 0.10823272943060622 2.442198312070637e-07 6.612219073257201 -0.6991826403162404 VET(ph)GVLKPGMVVTFAPVNVTTEVK ddPTM_A459_Selumetinib_30min_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 VET(1)GVLKPGMVVTFAPVNVTTEVK;VET(0.959)GVLKPGMVVT(0.041)FAPVNVT(0.001)TEVK 109.44 5.815e-07 99808000.0 3471.0 6245.0 6943.8 7205.1 4960.700000000001 5906.9 5533.200000000001 5268.6 2720.3999999999996 4798.6 True False 3551.867546609704 5513.832496778263 6000.870099563162 5946.86454147778 4512.0055608827215 5847.481949036085 5115.826269195125 5128.859613175303 4616.320109845244 5414.547052322203 0.6559860893786805 1.0183367959492526 1.1082866288860662 1.0983124689861685 0.8333117280692209 1.0799577310032247 0.9448299589530833 0.9472370566944517 0.8525773375383978 1.0 12.40262494055659 -10.13364360080877 14.044418693923351 0.9999999975036561 0.9601994045563855 0.006564510080785291 0.13392536459250787 0.0 0.0 0.1287889924294106 0.031235918776666666 7.351168866213618e-11 10.13364360080877 -0.03980059294727056 VET(ph)PSHPGGVSEEFWER ddPTM_A459_Selumetinib_30min_R1 2 VETPSHPGGVSEEFWER 17 0 Q92620;H3BQT9 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 1 VET(0.969)PS(0.031)HPGGVSEEFWER;VET(0.98)PS(0.02)HPGGVSEEFWER 98.292 0.0071152 7665700.0 1872.3400000000001 2079.75 2209.97 2168.34 2344.8999999999996 1559.8600000000001 2257.6000000000004 1853.08 997.31 1559.9 True False 1915.9618790605634 1836.2519031504553 1909.8682124962709 1789.680123782866 2132.8042090257204 1544.169224639561 2087.307414395814 1803.9302987478457 1692.3622293595658 1760.128359712709 1.088535315329667 1.043248859106032 1.0850732572753972 1.0167895505501545 1.211732199675392 0.8773048943382759 1.1858836333598464 1.0248856504092043 0.9614993247627667 1.0 10.781464927824898 -7.997758365956927 24.986339872986626 0.984897242803817 1.0703793251967897 0.15392485003222534 0.08690722051547879 119.23372411141001 1329036.2096222723 0.04442323900734929 0.021114630315214742 1.0051748968951957e-08 7.997758365956927 0.08548208239297272 VETGVLKPGMVVTFAPVNVTTEVK ddPTM_A459_Selumetinib_30min_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 ; 119.41 4.2277e-07 34230000.0 4338.0 4569.4 4900.2 5349.5 4688.7 4902.0 4296.1 4718.5 3354.1 3925.0 False True 4439.0669597213755 4034.412523743569 4234.779754871886 4415.310247551788 4264.607912857216 4852.690330659884 3972.0417181900475 4593.350052151934 5691.662726228476 4428.811982737598 1.0023155141883984 0.9109468948938679 0.956188650901867 0.9969513866837346 0.9629236755770153 1.0957092668585748 0.8968639295757131 1.0371517395761356 1.2851443566385645 1.0 12.11270403615722 -8.010657610174462 24.385617285663887 1.1487641721077129 0.9758011869118116 0.3976768138220954 0.08200382517254368 313.8040423358752 718008.1417844667 0.04582241954478864 0.019716352966809778 9.757586047934816e-09 8.010657610174462 -0.17296298519590125 VETGVLKPGMVVTFAPVNVTTEVK ddPTM_A459_Selumetinib_30min_R2 1 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;A0A087WVQ9;Q5VTE0 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 208.46 2.8746999999999997e-31 113480000.0 351630.0 329040.0 324340.0 322810.0 388820.0 278260.0 211990.0 291360.0 209490.0 245860.0 False True 332087.8122864176 354276.3099696439 303472.3175146906 278842.7211216889 339972.9555050968 316587.7892072168 221847.95505021614 292207.80936275516 251393.85363966075 238761.3829790048 1.3908774029660371 1.4838090881756902 1.2710276416072532 1.1678719466380734 1.423902606289527 1.3259589354743166 0.9291617944335835 1.223848704999544 1.0529083493446123 1.0 17.86520998989259 -6.787305431036809 0.3534210366818982 0.9822898044177634 1.481320393937992 0.5532258272320086 0.11907471595326588 1.4574723158644232 0.37945302560010546 0.14453966004959373 0.2723850065321473 1.6319038573277084e-07 6.787305431036809 0.4990305895202286 VETLSPESALQGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 VETLSPESALQGSPR 15 0 Q99958 Q99958 FOXC2 Forkhead box protein C2 1 VETLS(0.006)PES(0.001)ALQGS(0.993)PR 100.68 0.0074319 4102300.0 730.91 810.79 982.03 885.96 944.44 766.33 719.86 728.41 424.78 818.43 True False 747.9387808967151 715.8623298739554 848.6757199046651 731.2437175289241 859.015568754425 758.6214159719684 665.5603806373889 709.0902005908639 720.8206352963032 923.4834626832949 0.8099103136329988 0.7751761225847286 0.9189939551691954 0.7918319570165399 0.9301905269190739 0.8214780736492027 0.7207063337155181 0.7678428788865531 0.7805452554633411 1.0 9.85094231609514 -9.8969348995624 15.072062185844608 1.0000000671695963 0.8140052861693533 0.449485700535317 0.062087711054281826 0.0 0.0 0.06332430393329615 0.015358399634452704 1.2678419002242422e-10 9.8969348995624 -0.18599478100024303 VETLSPESALQGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VETLSPESALQGSPR 15 0 Q99958 Q99958 FOXC2 Forkhead box protein C2 1 VETLSPES(0.009)ALQGS(0.991)PR 138.81 0.00039609 3748800.0 8436.8 10138.0 8518.5 10219.0 10778.0 9016.6 6960.0 7752.2 5983.3 9570.0 True False 7967.916431186334 10915.552001192118 7970.42898424153 8827.154571241734 9423.971283457475 10258.55480545457 7283.653790978361 7774.757618554207 7180.127187370196 9293.689234153879 0.8573469835751134 1.1745122659231997 0.857617334023885 0.9498009185418368 1.0140183350251066 1.1038194356397086 0.7837203942876926 0.8365631153215595 0.7725809424510947 1.0 13.182035688942522 -7.2749383697834595 24.9966525519902 0.8345963678743216 0.9939679423657141 0.29522209580392755 0.10865985672537984 924.1606141314321 1711300.633583055 0.04343151853053548 0.029460098394682374 5.3095978676066044e-08 7.2749383697834595 0.1593715744913925 VETVSQPSES(ph)PKDTIDK ddPTM_A459_Selumetinib_30min_R2 1 VETVSQPSESPKDTIDK 17 1 F8VXG7;A0A0A0MTP7;Q99590-2;Q99590 F8VXG7 SCAF11 Protein SCAF11 1 VET(0.004)VS(0.151)QPS(0.075)ES(0.766)PKDT(0.003)IDK 74.444 0.012755 12149000.0 46159.0 27462.0 34826.0 33798.0 27497.0 28680.0 62580.0 47364.0 38662.0 19306.0 True False 43593.667569117424 29568.247095752413 32585.333075681814 29194.65409519798 24042.581033701066 32630.40966888152 65490.09399991748 47501.821398467706 46395.480306537596 18748.585616987955 2.325171000078935 1.5770921444314627 1.7380155357509466 1.5571656812738408 1.2823677222838752 1.7404198020844488 3.493068508622719 2.5336215951899144 2.4746122856595107 1.0 14.194494143140718 -7.041047626220055 24.94712578065486 2.519358650152996 1.6667245215881934 0.20522297067162631 0.6217048086104655 603.0357654502797 366499.4987769809 0.22585212071995414 0.17496576335778594 9.09813493898066e-08 7.041047626220055 -0.8526341285648025 VEVAAPAHRGT(ph)PDTDLEVQR ddPTM_A459_Selumetinib_30min_R2 1 VEVAAPAHRGTPDTDLEVQR 20 1 P0C7T5 P0C7T5 ATXN1L Ataxin-1-like 1 VEVAAPAHRGT(0.992)PDT(0.008)DLEVQR 68.634 0.007427 4013600.0 52276.0 62926.0 67328.0 69006.0 74226.0 37906.0 25976.0 23193.0 18485.0 55322.0 True False 49370.70919740856 67752.22186101935 62996.189781183726 59607.26375801025 64901.06629114079 43127.20742359217 27183.935470467528 23260.487790192168 22182.516514053797 53724.71011618189 0.9189572003393296 1.261099812628163 1.17257384255684 1.1094943765933236 1.208030088031924 0.8027443485563313 0.5059857077252005 0.43295697156653634 0.41289225136968066 1.0 15.71329817283629 -6.9704853076922975 3.185155647984429 0.5446592990080922 1.1415847620469364 0.6773355172242357 0.17699179662415124 0.13064281780060746 2.73928797708095 0.0659542000433631 0.054670542929408324 1.0703225916211799e-07 6.9704853076922975 0.5969254630388442 VEVAHIS(ph)GGE ddPTM_A459_Selumetinib_30min_R2 1 VEVAHISGGE 10 0 O95625 O95625 ZBTB11 Zinc finger and BTB domain-containing protein 11 1 VEVAHIS(1)GGE 88.134 0.032676 5714200.0 31319.0 36012.0 37883.0 43495.0 38834.0 29485.0 32465.0 32246.0 25997.0 32417.0 True False 29578.415359890576 38774.00460316933 35445.64902389176 37570.90596693996 33955.32573963513 33546.291111819104 33974.6868281771 32339.830521387317 31197.126416870804 31481.03698051892 0.9395629304776166 1.2316622424846881 1.1259365136487156 1.1934456285601256 1.0785961644353506 1.065603116332483 1.079211172402018 1.0272797094136332 0.9909815371131578 1.0 14.94219544333043 -7.454337469885253 0.9406486846274199 0.9945017178073147 1.1261814484756196 0.2788778708619989 0.07332542398207331 0.7053874503978792 1.165790055540463 0.05796652150753347 0.028870823343198043 3.512873654992576e-08 7.454337469885253 0.13167973066830496 VEVERDNLAEDIMR ddPTM_A459_Selumetinib_30min_R1 2 VEVERDNLAEDIMR 14 1 P08670;B0YJC4 P08670 VIM Vimentin 0 ; 144.51 0.0014913 21035000.0 2923.1 2513.7 11089.7 10897.2 7316.5 5339.799999999999 4037.0 3281.9 2747.0 2325.9 False True 2991.2025426375176 2219.394835412573 9583.779651361738 8994.208585778362 6654.723866832994 5286.086460150478 3732.4858397926528 3194.8533508863893 4661.458367058113 2624.451921184556 1.1397436998150179 0.8456603138726355 3.6517261276541366 3.4270807223318434 2.535662327481069 2.0141677648888243 1.4221963106521616 1.2173411618241345 1.776164512457194 1.0 11.35780045290845 -7.1339937799578665 3.0220430371685167 1.3635596166141564 2.3686985079401848 0.2290309138015817 0.8342296196428242 0.46206834319946577 8.048436141401181 0.39296169134065645 0.29328353892327647 7.345243880695592e-08 7.1339937799578665 1.0051388913260284 VEVKEEEESSSNGTASQSTS(ph)PSQPR ddPTM_A459_Selumetinib_30min_R1 2 VEVKEEEESSSNGTASQSTSPSQPR 25 1 Q92793-2;Q92793;I3L466 Q92793-2 CREBBP CREB-binding protein 1 VEVKEEEESSSNGT(0.001)AS(0.003)QS(0.019)T(0.122)S(0.828)PS(0.028)QPR;VEVKEEEESSSNGTAS(0.002)QS(0.037)T(0.037)S(0.602)PS(0.321)QPR 144.44 2.0704e-09 14089400.0 1419.52 1741.52 2131.63 2219.1 1910.3 1503.1599999999999 1505.48 1589.78 965.01 1167.01 True False 1452.592054094904 1537.6220287893168 1842.166354205454 1831.5758426660757 1737.5137022908589 1488.0395751600804 1391.9204315310978 1547.6138700667793 1637.5514884582265 1316.807101140026 1.1031168140248653 1.167689654360248 1.3989644744553686 1.3909219057828506 1.319489924368274 1.130036110734678 1.0570420149815736 1.1752775852491473 1.243577352400755 1.0 10.362828305570622 -6.770347889031132 24.493551383480746 1.1281323743723795 1.2832291305794727 0.35265297834009146 0.1044617906016638 190.81463891893145 524632.3104119989 0.039673031264416854 0.0355146622771343 1.6968838291204433e-07 6.770347889031132 0.1550967562070933 VEVKEEEESSSNGTASQSTS(ph)PSQPR ddPTM_A459_Selumetinib_30min_R2 1 VEVKEEEESSSNGTASQSTSPSQPR 25 1 Q92793-2;Q92793;I3L466 Q92793-2 CREBBP CREB-binding protein 1 VEVKEEEESSSNGT(0.001)AS(0.004)QS(0.018)T(0.105)S(0.653)PS(0.219)QPR 92.098 1.7246e-05 5304400.0 21773.0 17638.0 23072.0 23451.0 23602.0 16339.0 15637.0 17456.0 12164.0 18623.0 True False 20562.943824224814 18990.777884891166 21587.572638894235 20256.933344768553 20636.90575544288 18589.54893932548 16364.151484127677 17506.794070003627 14597.139890557233 18085.30560163506 1.1369973102564412 1.0500667394403467 1.1936526323858492 1.1200769171927711 1.1410869249329763 1.027881383306281 0.9048313500794934 0.9680120676766927 0.807127079413993 1.0 14.142530356102071 -7.0264153118062564 2.705963912161241 0.9165410959656539 1.1274418789435803 0.7440481313235623 0.05744476615062434 0.13516098303832622 1.9815231643664957 0.022646007722808423 0.017858173135835764 9.409893067295518e-08 7.0264153118062564 0.21090078297792636 VEVKVPPAPVPCPPPSPGPSAVPSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 VEVKVPPAPVPCPPPSPGPSAVPSSPK 27 1 O95817 O95817 BAG3 BAG family molecular chaperone regulator 3 1 VEVKVPPAPVPCPPPS(0.009)PGPS(0.05)AVPS(0.117)S(0.824)PK 91.213 1.3076e-05 12072000.0 713.31 479.85 3616.9 3264.1 1687.9 954.31 736.89 811.65 928.65 655.95 True False 729.9287351403544 423.6689389237873 3125.7448462095676 2694.0862097455424 1535.2297430229482 944.710507844152 681.3057940264573 790.122405389237 1575.8512240875566 740.1475719940709 0.9861935143201439 0.5724114419268557 4.223137337042575 3.6399311592514745 2.0742211433414615 1.2763812833959007 0.9204999378582236 1.0675200936760845 2.129104091825867 1.0 9.53166913640587 -6.680307991742794 4.405558957132283 1.2584705891209702 2.411994923515429 0.18997634624241744 1.0585280688925447 0.39293347570788784 14.134226741447575 0.40003769341781836 0.3937100289107076 2.087814974946001e-07 6.680307991742794 1.1535243343944588 VEVS(ph)EDEPASK ddPTM_A459_Selumetinib_30min_R1 2 VEVSEDEPASK 11 0 O75683 O75683 SURF6 Surfeit locus protein 6 1 VEVS(1)EDEPASK;VEVS(1)EDEPASK 163.71 0.00064187 21462000.0 4245.5 3640.7000000000003 4128.4 4051.5 4224.6 3806.5 4472.0 4107.1 2481.3999999999996 3124.3 True False 4344.411889695048 3214.44515148449 3567.785955677951 3343.9815810741293 3842.4856759137074 3768.2100660254728 4134.673439572146 3998.166366259025 4210.754565714597 3525.3343382591297 1.2323403889800684 0.9118128503726083 1.012041869889647 0.9485572885337862 1.089963477850215 1.0688943812025158 1.1728457623721211 1.13412402417224 1.1944270136358017 1.0 11.783544372038783 -6.765555378534347 2.0167898044187975 1.1337197787087412 1.0191474354821444 0.14888158604234292 0.0943240912472777 0.485760180239903 4.069197846718892 0.03636995459015011 0.03331447997421597 1.715712919119004e-07 6.765555378534347 -0.11457234322659682 VEVS(ph)EDEPASK ddPTM_A459_Selumetinib_30min_R2 2 VEVSEDEPASK 11 0 O75683 O75683 SURF6 Surfeit locus protein 6 1 VEVS(1)EDEPASK;VEVS(1)EDEPASK 163.99 0.0005985000000000001 30542000.0 168686.0 135550.0 146179.0 171518.0 158104.0 139436.0 155710.0 152346.0 129998.0 144721.0 True False 159311.10742356072 145946.2491380539 136774.00228766116 148156.95251494634 138241.56205230646 158642.04332601666 162950.8235335116 152789.301637762 156001.23244760427 140542.52869968477 1.1335437671253317 1.0384490053535038 0.9731858644718404 1.0541787876289908 0.983627968923947 1.1287831860846012 1.1594413807774122 1.0871392670345819 1.1099930668029467 1.0 17.1006472359145 -6.775735664097105 24.995581030673154 1.1064157157789687 1.0341538734539295 0.2154832977998663 0.05620363095345371 316.2525363949288 552931.4031416673 0.019518369770033565 0.017288763405482518 1.6759626502203993e-07 6.775735664097105 -0.07226184232503918 VEVT(ph)PTVPR ddPTM_A459_Selumetinib_30min_R1 1 VEVTPTVPR 9 0 Q8IXS8 Q8IXS8 FAM126B Protein FAM126B 1 VEVT(0.991)PT(0.009)VPR 110.54 0.025239 5929700.0 1547.1 1968.6 1677.2 1722.0 1851.9 1432.4 1556.1 1700.8 966.36 1049.1 True False 1583.1444198674367 1738.1153968226884 1449.445452200141 1421.2850259433915 1684.3959719794998 1417.991356515142 1438.7221241767027 1655.6892590229959 1639.8423398581276 1183.7622040993667 1.3373838211635833 1.4682977635234487 1.224439711946127 1.200650790354248 1.4229175134553538 1.1978684161435802 1.2153810277050663 1.398667108384899 1.3852801974749287 1.0 10.20916358402238 -10.690295307412107 4.232199781158846 0.9999070534197134 1.314143570072317 0.4937164165132598 0.09619843455790056 71249757.95034482 61476149.1644975 75345.39802022337 0.024828689563009897 2.0403500951125972e-11 10.690295307412107 0.31423651665260355 VEVTEFEDIK ddPTM_A459_Selumetinib_30min_R1 2 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 ; 161.76 0.0058172 13154500.0 3730.5 4132.1 3639.2 3568.3 3682.3 3905.5 3774.4 3249.3 3066.3 3742.8 False True 3817.4133917106033 3648.3118110388286 3145.0166286946996 2945.1633902867634 3349.236615162867 3866.214215910278 3489.6939692131277 3163.1180087861144 5203.2871463088095 4223.224837959308 0.9039095805174332 0.8638687143168343 0.7446955228209904 0.6973730983524635 0.793051931561674 0.9154649265082604 0.8263102494205287 0.7489816739936004 1.2320649138877187 1.0 12.044129340698815 -8.25519455683023 24.99856921438519 1.1160324660534158 0.8107243796315191 0.6761154449682532 0.08425033873058457 261.5100575579573 1046858.3288418762 0.06135597962553104 0.02190534575110247 5.556552770219801e-09 8.25519455683023 -0.30530808642189666 VEVTEFEDIK ddPTM_A459_Selumetinib_30min_R2 3 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 ;; 166.19 0.0046237 14001900.0 95633.0 77180.0 90421.0 92142.0 80959.0 60438.0 71528.0 82727.0 57803.5 78430.0 False True 90318.10070923122 83099.45782718582 84603.41130294111 79592.10064618429 70788.20663735703 68762.78589846088 74854.19373004309 82967.72187380781 69365.81516473393 76165.52211438755 1.1858134520969859 1.0910377231102635 1.1107835796868994 1.0449885779900596 0.9293996111658669 0.9028072543793629 0.982783176062588 1.0893081222394105 0.9107246066082021 1.0 16.21685045953768 -5.909349056194792 2.6277899670459157 0.9713180757111046 1.1292124929108136 0.6295824399022911 0.05499573182689611 0.19355723100246175 2.7078795768039714 0.017371317804558445 0.027995460409415744 1.2321141460963465e-06 5.909349056194792 0.15789441719970898 VEYISS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 VEYISSPLK 9 0 Q15697 Q15697 ZNF174 Zinc finger protein 174 1 VEYIS(0.028)S(0.972)PLK 130.41 0.0036857 0.0 83397.0 58516.0 51730.0 73621.0 47147.0 54663.0 78162.0 72075.0 57496.0 54423.0 True False 78762.12860464235 63003.98904140444 48401.74811936544 63593.69279669119 41223.97236047222 62192.332068691416 81796.68787506469 72284.72631734141 68996.80657246624 52851.66658206441 1.4902487224758743 1.1920908670604777 0.9158036302263156 1.2032485805901183 0.7799938020206512 1.1767336035113192 1.547665251918905 1.3676905761354317 1.305480243756037 1.0 15.689661344662998 -7.013283699560582 24.865128403457984 1.3396141397166028 1.1006013765661395 0.13624104493116396 0.2163903167351034 954.4944916772125 1786671.4840309564 0.08028098889036772 0.0651646800713187 9.69876196031205e-08 7.013283699560582 -0.23901276315046327 VFCVEEEDS(ph)ESSLQK ddPTM_A459_Selumetinib_30min_R1 4 VFCVEEEDSESSLQK 15 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VFCVEEEDS(0.851)ES(0.043)S(0.105)LQK;VFCVEEEDS(1)ESSLQK;VFCVEEEDS(0.729)ES(0.22)S(0.051)LQK;VFCVEEEDS(0.975)ES(0.024)SLQK 312.25 5.8817999999999954e-198 12027600.0 1754.68 2255.73 2123.2799999999997 1836.4599999999998 2202.35 2121.36 2118.54 2058.85 1007.27 2005.5900000000001 True False 1795.5606299870701 1991.6280829395732 1834.9502383421855 1515.756735623694 2003.1478313564728 2100.02104444077 1958.736822153661 2004.2426099126849 1709.2636219099481 2263.0270126009414 0.7934331406514662 0.8800726071097825 0.8108388579212058 0.6697917113599122 0.8851630228903966 0.9279699414754994 0.8655384187846906 0.8856467902295031 0.7552996992048531 1.0 11.144038090085642 VFCVEEEDS(ph)ESSLQK ddPTM_A459_Selumetinib_30min_R2 2 VFCVEEEDSESSLQK 15 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VFCVEEEDS(1)ESSLQK;VFCVEEEDS(0.998)ES(0.002)SLQK 204.35 3.5121e-29 0.0 13871.9 11508.6 13946.7 16197.400000000001 17152.3 11336.3 14803.199999999999 13859.099999999999 12047.5 13369.6 True False 13100.955331615502 12391.272614018504 13049.384506018827 13991.286177926502 14997.47473049246 12897.77242431455 15491.578131984315 13899.427686502486 14457.336635275266 12983.584909607487 1.0090399086866342 0.954379911271602 1.0050679066582489 1.077613484668117 1.1551104594690755 0.9933906940270835 1.1931664667222213 1.0705385133051581 1.1135088448936197 1.0 13.664401161748879 -5.733873312217281 3.581291094009851 1.0936154397720919 0.9817137721294471 0.360770886531539 0.05918120682405476 0.2155059542369178 5.788289970406146 0.01574073387194912 0.027390461994404317 1.8455537060281551e-06 5.733873312217281 -0.11190166764264475 VFDDES(ph)DEKEDEEYADEK ddPTM_A459_Selumetinib_30min_R2 2 VFDDESDEKEDEEYADEK 18 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 VFDDES(0.89)DEKEDEEY(0.11)ADEK;VFDDES(0.969)DEKEDEEY(0.031)ADEK 58.688 0.030597000000000006 290650000.0 77148.0 43027.0 46721.0 47870.0 43846.0 44764.0 76756.0 67277.0 48485.0 40488.0 True False 72860.42300791324 46327.032546389164 43715.0217259786 41350.023419643985 38337.673491786656 50929.8346728665 80325.30608912864 67472.76493169302 58183.354784089715 39319.00623954255 1.853058608959414 1.1782350821419985 1.11180382992526 1.0516548451842325 0.9750417713566478 1.295298115180925 2.042912926124431 1.7160343402534077 1.479776839465886 1.0 15.262939238577856 -7.023393273683815 24.343910142067855 1.6264584780471958 1.206070775518858 0.166745810450043 0.3317976627546624 764.9038353793235 795985.0466899731 0.1250719252644311 0.09758107882010039 9.475600153803481e-08 7.023393273683815 -0.4203877025283378 VFDKDGNGYISAAELR ddPTM_A459_Selumetinib_30min_R1 2 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 ; 139.64 0.0011317 74661000.0 6483.5 7590.9 8974.6 9771.5 7803.3 6944.4 7034.200000000001 6938.4 4136.1 6013.4 False True 6634.552935305105 6702.153899086333 7755.898613949074 8065.090958772272 7097.492892784515 6874.545641010714 6503.604630733093 6754.371092900489 7018.6596112082525 6785.278465476251 0.9777863899119185 0.9877492770837838 1.1430479461397753 1.1886160604620362 1.0460135024519366 1.0131560076699369 0.9584875055347654 0.9954449367504931 1.0343952200222075 1.0 12.72819230922558 -6.702307901371925 3.7337740335205174 0.9965009052906962 1.077132653746108 0.24068341635878154 0.0616275421516031 0.35453219588023654 9.987873813734785 0.02415325330088138 0.023392768839650885 1.984687336437865e-07 6.702307901371925 0.08063174845541166 VFDLQFSTDS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 VFDLQFSTDSPR 12 0 C9J470;E9PHA2;Q15003;C9JZP1 C9J470 NCAPH Condensin complex subunit 2 1 VFDLQFS(0.001)T(0.016)DS(0.983)PR;VFDLQFST(0.005)DS(0.994)PR 129.17 0.0023473 15572700.0 1902.48 2279.7 2322.8 2588.5 2421.2 1712.5 1953.38 1797.3600000000001 1321.97 2023.41 True False 1946.8040824183333 2012.7916641962236 2007.3765182270974 2136.4670671628737 2202.2028874975776 1695.2738048255917 1806.03497392474 1749.6881741519119 2243.2865371313496 2283.134383182442 0.8526892226574502 0.8815914117988141 0.8792196083653351 0.9357605416921934 0.9645524607394969 0.7425203778248759 0.7910331460241612 0.7663535650989742 0.9825468678740019 1.0 11.156800062422317 -4.496219472608329 16.596068428339517 0.87189593438163 0.7995385969092812 0.0 0.08711019239323654 6697005.023892642 119958760.19262575 0.02219490767177437 13213944.786489187 3.189925405006174e-05 4.496219472608329 -0.07235733747234885 VFDMLNRR ddPTM_A459_Selumetinib_30min_R1 1 VFDMLNRR 8 1 P60842;P60842-2;J3KT12;J3QS69;J3QL43;J3KTB5;J3KSZ0;J3QR64;Q14240-2;Q14240;E7EQG2;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 101.72 0.022735 6721300.0 3731.5 2535.2 6000.9 5989.6 4696.5 3447.3 3058.3 3438.5 2257.1 2350.6 False True 3818.4366897649415 2238.377605417495 5186.010740584205 4943.628798716921 4271.702404234422 3412.623291897967 2827.6099687485453 3347.2998101779026 3830.13384793843 2652.322406782929 1.4396578183707398 0.8439311901498737 1.9552716243401391 1.8638868284166015 1.6105517162280738 1.2866547758940161 1.066088331311964 1.262025989607323 1.4440679753499872 1.0 11.37304043959814 -6.867467444229538 5.091089911239512 1.2106139071104394 1.5436570087551136 0.2361096134561843 0.3000746119337559 0.36800726938669737 15.092434288162394 0.1162468419953089 0.1026812157884417 1.3568522394310343e-07 6.867467444229538 0.3330431016446742 VFGS(ph)LER ddPTM_A459_Selumetinib_30min_R1 2 VFGSLER 7 0 Q14680-3;Q14680-4;Q14680-5;Q14680-2;Q14680-8;Q14680-6;Q14680;Q14680-7 Q14680-3 MELK Maternal embryonic leucine zipper kinase 1 VFGS(1)LER;VFGS(1)LER 96.034 0.023406 94686000.0 5764.5 7156.5 7421.5 8360.099999999999 7642.5 6481.6 7166.8 6106.9 3280.8 5609.3 True False 5898.801634235564 6318.613653033415 6413.701063381438 6900.165473512977 6951.237224392962 6416.4009888219325 6626.202505976216 5944.925173993142 5567.277979848655 6329.308294208917 0.9319820365888559 0.9983102985858207 1.0133336480464599 1.0901926644695714 1.0982617533029775 1.0137602231657292 1.0469078448965659 0.9392693320741745 0.8796029077841743 1.0 12.627832126331183 -7.787572649649286 8.75330334364188 0.9316730982769416 1.0304685660546837 0.37033685663882665 0.05212906382999381 0.25921664773239367 76.19026141986716 0.02959475409126769 0.014501864431527794 1.6309000661836225e-08 7.787572649649286 0.09879546777774217 VFIDQNLS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 VFIDQNLSPGK 11 0 F5H452;Q5JSB6;Q5JSB5;Q14186 F5H452 TFDP1 Transcription factor Dp-1 1 VFIDQNLS(1)PGK 129.54 0.0025661 28938000.0 4246.7 5607.5 3490.2 3778.5 3609.4 3387.5 4555.1 3873.5 2431.8 4467.5 True False 4345.639847360253 4950.971293143976 3016.2500102962877 3118.6559062294473 3282.930407291327 3353.424825603909 4211.505139667953 3770.7621970987634 4126.586988355266 5040.947142135086 0.8620681242691355 0.9821510032828868 0.598349858716979 0.6186646712007666 0.6512526941317711 0.6652370538810234 0.8354590954675584 0.7480265296933192 0.818613421645095 1.0 12.299479111419721 -8.83208375587688 1.0152850746348598 0.9999062874985044 0.735196214621552 0.31493785757481874 0.11418474167251394 1.4422170009676138 2.6782526763817196 0.12150838414700436 0.039063917345066035 1.4720285869338055e-09 8.83208375587688 -0.26471007287695236 VFIDQNLS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 3 VFIDQNLSPGK 11 0 F5H452;Q5JSB6;Q5JSB5;Q14186 F5H452 TFDP1 Transcription factor Dp-1 1 VFIDQNLS(1)PGK;VFIDQNLS(1)PGK;VFIDQNLS(1)PGK 138.55 0.0012417 53543300.0 248354.0 220735.0 229641.0 232276.0 222673.0 194927.0 246298.0 247773.0 190378.0 201288.0 True False 234551.4789198331 237664.66472510766 214866.14807421574 200639.60810155066 194698.82701812265 221776.4248788727 257751.3450302283 248493.97840897177 228458.9196057637 195476.29243096785 1.1998973174850072 1.2158234728594444 1.0991928760368492 1.0264140249764877 0.9960227125081178 1.1345438473424736 1.3185811017018996 1.2712230998381915 1.16872955162296 1.0 17.576634121016674 -7.016973570578991 24.72256117021074 1.2142821048455161 1.104202407903444 0.1104095301507424 0.10075126078795164 1080.9699448008496 1574465.5373167607 0.0393139299918621 0.031239346416781597 9.616708000323395e-08 7.016973570578991 -0.11007969694207209 VFLENVIR ddPTM_A459_Selumetinib_30min_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 143.89 0.029408 36769000.0 3960.3 2230.0 1006.2 1127.0 4735.9 3503.8 924.08 989.99 3954.7 5913.3 False True 4052.567284597641 1968.9105633011252 869.5635666609722 930.1906064101063 4307.538681191054 3468.5549531958586 854.3759016189235 963.732249259276 6710.83706014005 6672.3296554196795 0.607369163977966 0.2950859242546348 0.13032383164022163 0.13941016922845648 0.6455824132868202 0.5198416643545907 0.12804761541194934 0.1444371454993194 1.0057712083648465 1.0 12.703974853494175 -8.27069282843268 24.808129695366194 1.0028858007691086 0.32295284644664307 0.6672866770913599 0.19109963622972306 410.47357225048705 1100448.914548406 0.18652796026276935 0.050867938498368036 5.3617575446933245e-09 8.27069282843268 -0.6799329543224655 VFLTDTDPNENFS(ph)AQGEDEWPPLRK ddPTM_A459_Selumetinib_30min_R1 1 VFLTDTDPNENFSAQGEDEWPPLRK 25 1 J3QRV5;Q6P1M3;Q6P1M3-2 J3QRV5 LLGL2 Lethal(2) giant larvae protein homolog 2 1 VFLT(0.001)DT(0.011)DPNENFS(0.988)AQGEDEWPPLRK 76.04899999999998 0.00015002 6538500.0 867.7 1138.1 1429.2 1638.6 1521.8 990.81 1055.5 1013.4 410.17 910.33 True False 887.9157217497092 1004.8507229116645 1235.122490033652 1352.4492703314993 1384.1534586956116 980.8433509835013 975.8827852120751 986.5213400128793 696.028532368484 1027.1797228650996 0.8644209985698091 0.9782618372847616 1.2024404907337347 1.3166627418998589 1.3475280205442624 0.9548897132116736 0.9500604066541124 0.9604174596254563 0.6776112464789125 1.0 10.004472912863148 -6.9759121186619595 23.2373184135049 0.9021167345542221 1.1463864944241398 0.3601760775424262 0.15685847881131268 125.70335071021582 121263.44224636395 0.06056256211764234 0.053407088393096845 1.0570313823758966e-07 6.9759121186619595 0.2442697598699176 VFPLS(ph)PASNLR ddPTM_A459_Selumetinib_30min_R1 1 VFPLSPASNLR 11 0 A0A2R8YH03;Q5VWN6;J3KPH3 A0A2R8YH03 FAM208B Protein FAM208B 1 VFPLS(0.942)PAS(0.058)NLR 142.76 0.00089481 16040000.0 1823.1 2261.3 2272.0 2862.4 1962.6 1727.7 1683.5 1598.5 1206.2 1664.4 True False 1865.5746828649249 1996.5459447501498 1963.4748792026703 2362.535573902652 1785.0831765251735 1710.320906626089 1556.5122396063737 1556.1025873402284 2046.833302637603 1878.0419526289074 0.9933615594973634 1.0630997576786605 1.0454904249898 1.257978060924328 0.9505022899123158 0.910693663808713 0.8287952446576328 0.8285771173332821 1.0898762403962379 1.0 10.875013575648266 -6.497970177267296 24.140981931329936 0.9162441450827624 1.0873037781167745 0.3801863813272722 0.09634096527166497 485.3371212572291 470381.2833609251 0.03011835067760543 0.033976916735538966 3.177092232112184e-07 6.497970177267296 0.17105963303401206 VFPLS(ph)PASNLR ddPTM_A459_Selumetinib_30min_R2 4 VFPLSPASNLR 11 0 A0A2R8YH03;Q5VWN6;J3KPH3 A0A2R8YH03 FAM208B Protein FAM208B 1 VFPLS(0.989)PAS(0.011)NLR;VFPLS(0.855)PAS(0.145)NLR;VFPLS(0.991)PAS(0.009)NLR;VFPLS(0.999)PAS(0.001)NLR 143.55 0.00083027 24933400.0 73112.0 67771.5 71816.90000000001 81228.59999999999 79480.2 62974.5 59882.5 66449.3 54188.0 61445.8 True False 69048.72773052526 72969.35613028145 67196.27884232847 70165.12455284932 69495.18671399669 71648.66574940644 62667.15490492267 66642.65646172613 65027.114139223566 59671.70009863869 1.1571436311750147 1.2228469443582373 1.1260996206116378 1.17585261416827 1.1646255528017393 1.2007143357901577 1.0501989184375913 1.116821815895379 1.0897479715129994 1.0 15.864759260664394 -8.20318802631407 0.4574701068324327 0.9975839557246401 1.18483745977656 0.6718268774148981 0.03744923276121033 0.579439764313384 0.3246464937595486 0.04343290401978782 0.026107003086840327 6.263426330563527e-09 8.20318802631407 0.18725350405191998 VFSGLVS(ph)TGLK ddPTM_A459_Selumetinib_30min_R1 2 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 1 VFS(0.001)GLVS(0.837)T(0.163)GLK;VFSGLVS(0.5)T(0.5)GLK 161.25 0.00054439 28739000.0 4270.8 3536.8 6725.700000000001 5843.6 6208.5 4044.6 6071.5 5989.700000000001 2607.8 5054.4 True False 4370.301330469816 3122.709811786289 5812.386881625619 4823.1249579574915 5646.942271199703 4003.914996202972 5613.521866807304 5830.833698712399 4425.246133823863 5703.181474025204 0.7662918233224894 0.5475382163461714 1.01914815583158 0.8456902484909735 0.9901389771513253 0.7020493762014345 0.9842790190657181 1.0223826341961202 0.7759258852236036 1.0 12.47755122435038 -5.261874479858587 24.999997722158867 0.9129779702525521 0.6569150160423177 0.448077193549689 0.11557697379618885 31.83485599997784 1829305.13187935 0.028460245187419464 0.0657479406918325 5.471740847378795e-06 5.261874479858587 -0.2560629542102344 VFSGLVS(ph)TGLK ddPTM_A459_Selumetinib_30min_R2 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 1 VFSGLVS(0.975)T(0.025)GLK 143.42 0.0008404 6198600.0 29981.0 25829.0 30663.0 33662.0 38242.0 20791.0 26697.0 25376.0 18219.0 22306.0 True False 28314.776043452173 27810.001246675 28690.17596335012 29077.17752981107 33437.69807218229 23654.77152809329 27938.463399101925 25449.839958777065 21863.309081392817 21661.967822051854 1.3071192920260812 1.2838169401380264 1.3244492005081625 1.342314685751243 1.5436131355593077 1.091995506706125 1.2897472486622663 1.1748627902987263 1.0092946892449908 1.0 14.40287668612277 -7.918224986525486 0.9869751490960286 0.9848750025844455 1.3358152882887615 0.603176512664696 0.10070091896168999 0.3713502789713799 0.6650846938455233 0.09199585275857067 0.03519231652576985 1.2071882884474188e-08 7.918224986525486 0.350940285704316 VFSGLVST(ph)GLK ddPTM_A459_Selumetinib_30min_R1 2 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 1 VFSGLVS(0.043)T(0.957)GLK;VFSGLVS(0.029)T(0.971)GLK 171.49 0.00070757 11666400.0 5910.1 5576.0 7441.200000000001 7231.9 6680.8 5851.200000000001 5795.1 6504.5 3079.9 4921.0 True False 6047.793830947287 4923.1593277879265 6430.725911585792 5968.984424576086 6076.522819591039 5792.342240464527 5357.970941338221 6331.979530406326 5226.365353004106 5552.658284599167 1.0891709017501447 0.8866310648798222 1.1581346414602949 1.0749778067797977 1.094344817948704 1.0431656233069748 0.9649379930688459 1.1403510185326335 0.9412366266982309 1.0 12.438962898621009 -10.252106213243994 8.90795753465312 0.9999959397504782 1.0453351308603949 0.023763512545006304 0.08333417465093483 0.0 0.0 0.07663325996399606 0.01858629560393958 5.59620721097982e-11 10.252106213243994 0.04533919110991669 VFSGLVST(ph)GLK ddPTM_A459_Selumetinib_30min_R2 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 1 VFSGLVS(0.31)T(0.69)GLK 99.539 0.040123 7606900.0 31071.0 26166.0 28736.0 31378.0 32031.0 22964.0 23959.0 27603.0 24328.0 29816.0 True False 29344.198207067904 28172.84806304922 26887.157045391144 27104.262269930823 28006.979419226787 26127.08255356329 25073.14097385783 27683.32016007735 29194.279781114466 28955.134608728513 1.0134367739468946 0.9729828040432085 0.9285799361224873 0.9360779231798236 0.9672543332188169 0.9023298598545383 0.8659307343126473 0.9560763758885177 1.0082591628606645 1.0 14.821531583297983 -8.176206783846741 4.683198648762543 1.003957433857582 0.939324616671818 0.2973743722410511 0.037965847155510844 0.28162432190996745 10.499754982919114 0.03051605721380132 0.01062645669756803 6.664893531430692e-09 8.176206783846741 -0.06463281718576408 VFVGGLS(ph)PDTSEEQIK ddPTM_A459_Selumetinib_30min_R1 1 VFVGGLSPDTSEEQIK 16 0 O14979-3;O14979-2;A0A087WUK2;O14979 O14979-3 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 VFVGGLS(0.871)PDT(0.1)S(0.03)EEQIK 166.79 1.5833e-05 4279400.0 960.04 1509.8 975.17 977.59 1036.6 1109.3 1306.9 1484.9 807.72 1760.7 True False 982.4070640873465 1333.0319141130228 842.7472702253824 806.87225813705 942.8397130265945 1098.1414491638127 1208.319480808774 1445.5156283650326 1370.6418464653004 1986.70299567034 0.49449115757530193 0.6709769487528457 0.4241938891026982 0.40613632731992766 0.47457506989285425 0.552745655267553 0.6082033819056436 0.7275952326619896 0.6899077765787672 1.0 10.956160496101976 -8.432501535142071 0.6556671785547996 0.9946464058102087 0.4927764542687745 0.7994134739668308 0.07584973658581863 0.3496787391961809 0.3512182239879392 0.08164581742019306 0.034395820687483855 3.69401338597879e-09 8.432501535142071 -0.5018699515414342 down VFVGGLS(ph)PDTSEEQIK ddPTM_A459_Selumetinib_30min_R2 1 VFVGGLSPDTSEEQIK 16 0 O14979-3;O14979-2;A0A087WUK2;O14979 O14979-3 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 VFVGGLS(0.929)PDT(0.035)S(0.035)EEQIK 114.63 0.002313 0.0 7055.3 6118.9 9683.8 11041.0 10863.0 5900.3 9030.0 9831.6 8791.1 7358.1 True False 6663.1946706036515 6588.199954635479 9060.754850924237 9537.19675321265 9498.292823547838 6713.012767409401 9449.912892605551 9860.208328291 10549.565643857093 7145.652534360249 0.932482322441978 0.9219871695350104 1.2680094375363367 1.334685209972432 1.3292407905191015 0.9394541275453184 1.3224702498708332 1.3798891397080486 1.4763614090006403 1.0 12.802850047571699 -5.261804307464109 24.75636971958433 1.2662882443974552 0.9272347103053412 0.4114519736091109 0.15704187048240803 25.546047703934207 1733204.9532275144 0.041417668718159446 0.09571981223503706 5.472625031256418e-06 5.261804307464109 -0.33905353409211403 VGAEDADGIDMAYR ddPTM_A459_Selumetinib_30min_R2 2 VGAEDADGIDMAYR 14 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 ; 173.04 0.0015461 7328400.0 24566.0 19509.1 26091.0 28447.0 29915.0 22558.8 21375.6 25743.7 20379.1 23557.9 False True 23200.72006548969 21005.385238356397 24412.333465732907 24572.46952618785 26156.81025650681 25666.06993160267 22369.607754947847 25818.609904901034 24455.48943962962 22877.72221622504 1.014118444406829 0.9181589425654986 1.0670788479291662 1.0740784984599947 1.143331054083532 1.1218804778300924 0.9777899890349733 1.1285480984899054 1.0689652233947318 1.0 14.481655799194558 -5.354702240240926 6.385353304686458 1.078926735515154 0.9667679513420444 0.37640445228300345 0.05450673759136437 0.20935922042484043 11.82353203363092 0.014026152269477524 0.029640310971442138 4.418732994477547e-06 5.354702240240926 -0.11215878417310954 VGALDVPASQFLGSAT(ph)SPGPR ddPTM_A459_Selumetinib_30min_R1 1 VGALDVPASQFLGSATSPGPR 21 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4 P49815 TSC2 Tuberin 1 VGALDVPASQFLGS(0.003)AT(0.498)S(0.498)PGPR 188.04 3.2742e-16 10150000.0 880.1 1074.8 1228.0 1231.8 1143.8 1078.1 1047.9 870.99 576.6 844.49 True False 900.6046176235101 948.9619163390361 1061.2443449211614 1016.6892537497497 1040.3434919542915 1067.2552928364798 968.8560593308697 847.8885158257524 978.4480868022235 952.8885175291915 0.9451311470923672 0.9958792648689513 1.1137130161594695 1.0669550897580247 1.091778810234662 1.1200211495924388 1.0167569883653143 0.8898087239253332 1.0268232524611662 1.0 9.896163626768482 -7.526370096985592 24.99223923554524 0.9656461492913819 1.0585641593251853 0.2805353540612361 0.05955045185858734 130.8799031287971 936854.0542381186 0.028910065592046282 0.01679792446482438 2.9759792790958224e-08 7.526370096985592 0.0929180100338034 VGALDVPASQFLGSATS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 3 VGALDVPASQFLGSATSPGPR 21 0 P49815;X5D2U8;A0A2R8YGD6;A0A2R8Y7C8;A0A2R8YDR3;A0A2R8Y7X5;A0A2R8YDZ2;H3BMQ0;A0A2R8YGU4;A0A2R8Y5F1;A0A2R8Y6C9;P49815-5;P49815-3;P49815-2;P49815-6;P49815-7;P49815-4 P49815 TSC2 Tuberin 1 VGALDVPASQFLGSAT(0.218)S(0.782)PGPR;VGALDVPASQFLGS(0.01)AT(0.229)S(0.761)PGPR;VGALDVPASQFLGSAT(0.239)S(0.761)PGPR 175.77 5.0995e-14 6404200.0 70284.0 73282.0 68436.0 84276.0 84008.0 64100.0 82373.0 75413.0 72362.0 64957.0 True False 66377.89664914426 78902.49376123093 64032.90226748299 72797.463415791 73454.16399895119 72929.19315813473 86203.50771900304 75632.43934470572 86836.4219632111 63081.52263144551 1.05225577760635 1.2508019855864865 1.0150817481308423 1.1540219763100994 1.1644323239961716 1.156110222389912 1.3665413281579772 1.198963439525534 1.3765746028445422 1.0 15.944929863176984 -7.02758303014904 22.30217147271752 1.2534181631215269 1.1325114247620096 0.16005775779949183 0.11439206428907517 293.78624742230704 237538.34976071733 0.040311019505122864 0.03134791756485327 9.384626005017403e-08 7.02758303014904 -0.12090673835951726 VGDDVEFEVSSDRR ddPTM_A459_Selumetinib_30min_R1 1 VGDDVEFEVSSDRR 14 1 O75534;O75534-4;O75534-2;O75534-3;E9PLD4 O75534 CSDE1 Cold shock domain-containing protein E1 0 207.95 8.6256e-06 9455400.0 2498.4 2552.5 2565.9 2737.5 2950.6 2397.8 2494.6 2357.0 1451.8 2259.2 False True 2556.607858959864 2253.652113374943 2217.464873479812 2259.4470142392784 2683.71875097074 2373.680309028209 2306.4303135860173 2294.4847033849974 2463.598564723324 2549.1903264715356 1.002909760174163 0.8840658502318804 0.8698702683958158 0.8863390821691585 1.0527730013338832 0.9311506812101163 0.9047697575325673 0.9000837166053861 0.9664239421986653 1.0 11.315823375874686 -8.510227855170857 5.413163017296068 0.9999426012411442 0.9276425301995767 0.15067017924561998 0.05437577336691148 0.27749660324277764 31.60924872472299 0.054425536522071404 0.014133097953100663 3.088674515969973e-09 8.510227855170857 -0.07230007104156755 VGDDVEFEVSSDRR ddPTM_A459_Selumetinib_30min_R2 2 VGDDVEFEVSSDRR 14 1 O75534;O75534-4;O75534-2;O75534-3;E9PLD4 O75534 CSDE1 Cold shock domain-containing protein E1 0 ; 116.71 0.0035322 10213900.0 24090.0 30067.0 27122.0 30012.0 29902.0 27116.0 24171.0 20807.3 24607.9 26272.0 False True 22751.174239910724 32373.042219357216 25377.00004820083 25924.31382641228 26145.44343272828 30850.982865459926 25294.999393927854 20867.84579816604 29530.167602173886 25513.459097146355 0.8917322481942643 1.2688613525940156 0.9946514877333592 1.0161034506415432 1.0247706253070408 1.2092042379667196 0.9914374721833412 0.817915192083855 1.1574348852397203 1.0 14.638970891346938 -7.496711260908752 24.906316484870782 0.9735402703110123 1.071708288191467 0.07352541335365848 0.12654451639782816 1508.5897790673737 1435886.7927407832 0.05067337670918294 0.03402543416361897 3.186315227650252e-08 7.496711260908752 0.0981680178804547 VGDGDLS(ph)AEEIPENEVSLR ddPTM_A459_Selumetinib_30min_R1 2 VGDGDLSAEEIPENEVSLR 19 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VGDGDLS(1)AEEIPENEVSLR;VGDGDLS(1)AEEIPENEVSLR 161.14 1.4993e-06 62190100.0 2567.36 3234.23 2725.9700000000003 2758.78 2859.49 2319.51 2918.74 2836.5699999999997 1531.4 2288.4700000000003 True False 2627.174492787063 2855.564848047264 2355.798246681385 2277.0108617143505 2600.849634383962 2296.177835346577 2698.577091908943 2761.3349491220947 2598.6739509693475 2582.2174160854825 1.017410260042988 1.1058576362544108 0.9123159932259546 0.8818044706576992 1.007215588502507 0.8892271506817858 1.0450619204636364 1.0693657830362502 1.0063730245103886 1.0 11.334394761644552 VGDGDLS(ph)AEEIPENEVSLR ddPTM_A459_Selumetinib_30min_R2 3 VGDGDLSAEEIPENEVSLR 19 0 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VGDGDLS(1)AEEIPENEVSLR;VGDGDLS(1)AEEIPENEVSLR;VGDGDLS(1)AEEIPENEVSLR 135.43 0.00018955 50065000.0 93485.5 72877.1 89236.6 105099.2 97599.8 76579.4 82545.4 91691.9 83831.9 75188.7 True False 88289.95016210768 78466.53923318982 83495.21430946366 90784.50765376762 85338.44057071749 87127.51723142063 86383.92466060705 91958.70824858872 100600.62245899407 73017.80686729618 1.209156422933482 1.0746219668826298 1.1434911275986321 1.2433201098296605 1.1687346447670366 1.193236567482336 1.183052851992702 1.2594011268472642 1.3777546433547008 1.0 16.155960716780314 -5.678403973775136 7.0605180959411475 1.211592690325586 1.1343797377070348 0.07650679442901154 0.09373495115892624 0.48380233706228054 34.32409792705206 0.02471128921127871 0.04292908939798202 2.0969883911066295e-06 5.678403973775136 -0.07721295261855121 VGDGDLS(ph)AEEIPENEVSLRR ddPTM_A459_Selumetinib_30min_R1 3 VGDGDLSAEEIPENEVSLRR 20 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VGDGDLS(1)AEEIPENEVSLRR;VGDGDLS(0.985)AEEIPENEVS(0.015)LRR;VGDGDLS(0.996)AEEIPENEVS(0.004)LRR 101.05 0.00037112 125232000.0 3393.3 2833.22 4175.76 4272.9 3531.27 3155.86 3315.92 3224.34 1752.1599999999999 1894.7400000000002 True False 3472.3572877875886 2501.5052852717563 3608.7147278078096 3526.718227266851 3211.8672519963557 3124.1149136916156 3065.797484737491 3138.8200290676186 2973.287547296884 2137.948335330506 1.6241539752880867 1.1700494553274825 1.6879335520752599 1.6495806605736592 1.5023128477516892 1.461267731340504 1.4339904449859162 1.468145874807769 1.3907200179546166 1.0 11.062011274641414 -9.38819138578719 0.5994344220093593 0.973404783152834 1.514216046765998 0.5547677390560734 0.13566163711728954 2.660933026522792 1.2365777932027653 0.30239871740723817 0.057154333872139286 4.090803456326731e-10 9.38819138578719 0.540811263613164 VGDGDLS(ph)AEEIPENEVSLRR ddPTM_A459_Selumetinib_30min_R2 5 VGDGDLSAEEIPENEVSLRR 20 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 VGDGDLS(0.994)AEEIPENEVS(0.006)LRR;VGDGDLS(1)AEEIPENEVSLRR;VGDGDLS(1)AEEIPENEVSLRR;VGDGDLS(0.999)AEEIPENEVS(0.001)LRR;VGDGDLS(0.999)AEEIPENEVS(0.001)LRR 125.96 0.00039312 70685200.0 81950.0 88883.4 87724.9 92121.0 95662.0 67367.5 53478.3 58154.3 52338.0 85750.6 True False 77395.5470718423 95700.47097482329 82080.7754416494 79573.96088241127 83644.08433086923 76646.761623723 55965.14691524108 58323.519385037354 62807.06244590466 83274.7573711844 0.9293998507478511 1.1492134470984188 0.985662138597258 0.9555592041862409 1.0044350409577132 0.9204081049684945 0.672054157609671 0.7003745339667488 0.7542148957090545 1.0 16.345591625027893 -7.051648708644231 4.050629787980101 0.7576924654032775 1.0068561960297842 0.5209337652245101 0.09964835606729201 0.1598379942482431 5.4051673737589825 0.03771210940201341 0.02976304907800779 8.878739035350396e-08 7.051648708644231 0.24916373062650665 VGDPPQPLPEEPMEVQGAERAS(ph)PEPQR ddPTM_A459_Selumetinib_30min_R1 2 VGDPPQPLPEEPMEVQGAERASPEPQR 27 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 VGDPPQPLPEEPMEVQGAERAS(1)PEPQR;VGDPPQPLPEEPMEVQGAERAS(1)PEPQR 102.49 3.2177e-07 82814000.0 4287.1 5496.0 4086.4 4511.4 4257.4 4592.0 4656.700000000001 4709.2 2500.2 4455.8 True False 4386.981088755538 4852.525764978917 3531.4893249884667 3723.5686794663266 3872.318921705021 4545.808649202406 4305.441369869324 4584.296718362592 4242.656792616925 5027.745333167436 0.8725543554911477 0.9651494742518846 0.7024001994873632 0.7406040745346405 0.7701899489935966 0.9041445713676564 0.8563364061952067 0.9117997063456126 0.843848785384698 1.0 12.295695860458444 -6.773840645035684 24.982057169053242 0.8947828013086669 0.8089359943222929 0.2570948023863412 0.07841595067841262 382.09070452559416 769707.7691838378 0.029403533157198854 0.026110352665879254 1.683291595201542e-07 6.773840645035684 -0.08584680698637404 VGDPPQPLPEEPMEVQGAERAS(ph)PEPQR ddPTM_A459_Selumetinib_30min_R2 3 VGDPPQPLPEEPMEVQGAERASPEPQR 27 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 VGDPPQPLPEEPMEVQGAERAS(1)PEPQR;VGDPPQPLPEEPMEVQGAERAS(1)PEPQR;VGDPPQPLPEEPMEVQGAERAS(1)PEPQR 82.94200000000002 4.4326e-05 112708000.0 183087.0 150695.0 188832.0 189095.0 206724.0 135466.0 132436.0 144174.0 131112.0 151851.0 True False 172911.75749533137 162252.82193920386 176682.75470473632 163339.93479293076 180753.48298399156 154125.21186208868 138594.53641695555 144593.5224707094 157338.06357536506 147466.66707372008 1.1725480810445865 1.1002677768399827 1.1981199427014297 1.107639699426281 1.2257243387322985 1.045152880447484 0.9398363655135078 0.9805166505758596 1.0669398495099247 1.0 17.170029363270558 -6.938848898317725 5.966105767056489 0.9946759213281365 1.155927539459318 0.7455014974230818 0.04571600080294374 0.09722318045302208 6.801202333122363 0.015729663009270332 0.01378875638684806 1.1512008502337495e-07 6.938848898317725 0.1612516181311815 VGDPPQPLPEEPMEVQGAERAS(ph)PEPQRENASPAPGTTAEEAMSR ddPTM_A459_Selumetinib_30min_R1 1 VGDPPQPLPEEPMEVQGAERASPEPQRENASPAPGTTAEEAMSR 44 2 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;H0Y710 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 VGDPPQPLPEEPMEVQGAERAS(0.917)PEPQRENAS(0.023)PAPGT(0.026)T(0.027)AEEAMS(0.007)R 41.56399999999999 0.0096129 6220300.0 70.244 206.21 161.74 122.79 240.95 0.0 225.02 0.0 0.0 125.25 True False 71.88054852896921 182.06683733557185 139.77659637422542 101.34703155376835 219.15611504317766 0.0 208.04656023535873 0.0 0.0 141.3270575383144 0.508611371247732 1.2882659591650574 0.9890292687678109 0.7171098961449242 1.5507017471425348 0.0 1.4720929159581235 0.0 0.0 1.0 7.142893890686077 -7.77759738970572 24.99996042804558 0.24999992400775684 0.9277900886371517 0.2206653743856679 0.5085636901359021 320.93370195810746 496547.2159345524 0.2573656369197932 0.12423464069026639 1.668793541493164e-08 7.77759738970572 0.6777901646293949 VGDQELPDQDEMDLS(ph)DWLVTPQESHK ddPTM_A459_Selumetinib_30min_R1 1 VGDQELPDQDEMDLSDWLVTPQESHK 26 0 B4DZ85;B4DF87;Q13772;Q13772-3;Q13772-4 B4DZ85 NCOA4 Nuclear receptor coactivator 4 1 VGDQELPDQDEMDLS(0.999)DWLVT(0.001)PQESHK 84.152 6.7369e-05 2797900.0 1487.9 1212.7 1427.5 1412.3 1622.3 1209.6 1447.9 1820.7 1033.8 1324.7 True False 1522.5651750505845 1070.7165202310657 1233.6533406962208 1165.6683171543864 1475.5632514403287 1197.4325222289265 1338.683737289022 1772.409121532907 1754.2830942354128 1494.738148670699 1.0186166563050743 0.7163238064026637 0.8253307388945239 0.7798478403665812 0.9871717348972306 0.8010985223691705 0.8955974920955491 1.1857656293238694 1.1736390723656396 1.0 10.545677056910412 -7.687926242336447 5.381180309213193 1.1341970320663604 0.8502427581983945 0.5948136231250432 0.09800690421311278 0.12344620504220685 6.339114785830759 0.04636084506866284 0.0258000521515439 2.0515105640431066e-08 7.687926242336447 -0.2839542738679659 VGDSTPVS(ph)EKPVSAAVDANASESP ddPTM_A459_Selumetinib_30min_R1 1 VGDSTPVSEKPVSAAVDANASESP 24 1 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 VGDS(0.024)T(0.129)PVS(0.844)EKPVS(0.002)AAVDANASESP 55.127 0.0086118 15293000.0 2728.0 3347.0 3164.4 2939.6 3068.3 2889.1 2711.1 3112.4 1724.0 2325.5 True False 2791.5570922360357 2955.131684021916 2734.6918608049896 2426.25404312613 2790.772806752364 2860.0382770929155 2506.599544280868 3029.8490414999856 2925.502084021912 2624.000577288227 1.0638553651238027 1.1261932293764572 1.0421841688888487 0.9246392947190363 1.0635564759046234 1.0899533719038361 0.955258762508091 1.1546678258093916 1.1149014635679966 1.0 11.357552322015481 -7.781149180294437 24.999959914800797 1.1010884323933068 1.0401326031307967 0.10477412926708651 0.0669529071449538 514.5461433292094 652642.7740247933 0.037070594777467304 0.01784586664529973 1.6552013036266982e-08 7.781149180294437 -0.060955829262510086 VGDSTPVSEKPVSAAVDANASES(ph)P ddPTM_A459_Selumetinib_30min_R1 2 VGDSTPVSEKPVSAAVDANASESP 24 1 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 VGDSTPVSEKPVSAAVDANAS(0.111)ES(0.889)P;VGDSTPVSEKPVSAAVDANAS(0.003)ES(0.997)P 109.26 2.3605e-07 101079000.0 7449.0 8228.5 9045.5 9469.1 8613.099999999999 6596.9 8878.4 7240.4 3951.1 6267.4 True False 7622.54720676914 7265.1033946741345 7817.1707833749 7815.499442021243 7834.046625766307 6530.5411755059595 8208.695139959153 7048.361071866243 6704.728123073653 7071.881839645764 1.0778668789453303 1.0273225089742237 1.1053876408894394 1.1051513047357036 1.1077739706916145 0.9234516814032457 1.1607511728971893 0.9966740440079668 0.9480826002332496 1.0 12.78787845436015 -7.979949660873298 24.82778747365645 0.9734869343298957 1.0696295842560088 0.32372673750792325 0.060722823666615605 236.10415602731587 292361.0943333169 0.032209657283372085 0.01547024747061636 1.0472499278838672e-08 7.979949660873298 0.0961426499261131 VGDSTPVSEKPVSAAVDANASES(ph)P ddPTM_A459_Selumetinib_30min_R2 4 VGDSTPVSEKPVSAAVDANASESP 24 1 Q9H8Y8-2;Q9H8Y8;Q9H8Y8-3 Q9H8Y8-2 GORASP2 Golgi reassembly-stacking protein 2 1 VGDSTPVSEKPVSAAVDANASES(1)P;VGDSTPVSEKPVSAAVDANAS(0.019)ES(0.981)P;VGDSTPVSEKPVSAAVDANAS(0.001)ES(0.999)P;VGDSTPVSEKPVSAAVDANASES(1)P 134.91 5.0074e-08 38607900.0 300450.0 295229.0 301939.0 348961.0 349908.0 263637.0 272608.0 289690.0 252510.0 316112.0 True False 283752.1917966449 317872.11498914525 282512.5734663259 301431.9098086976 305949.42882279103 299950.6036915937 285284.8121625039 290532.94993923913 303019.0557188928 306985.02520238765 0.9243193266823815 1.0354645630664883 0.9202812849912543 0.9819107938896073 0.9966265573413104 0.9770854571614483 0.9293118189541091 0.9464075641725453 0.987080902461349 1.0 18.22780875676461 -5.292239383817685 24.997901962741206 0.9659805581736716 0.9798920954664686 0.01805584423894724 0.03593267531238266 2951.2318285715396 2395269.9705889532 0.009098287179772051 0.01894079572188492 5.102236863348416e-06 5.292239383817685 0.013911537292797038 VGDVT(ph)PQVK ddPTM_A459_Selumetinib_30min_R1 4 VGDVTPQVK 9 0 E7ETY2;Q13428-6;Q13428-7;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 VGDVT(1)PQVK;VGDVT(1)PQVK;VGDVT(1)PQVK;VGDVT(1)PQVK 143.0 0.0048446 103438100.0 21569.399999999998 22772.1 23895.6 25052.1 21281.5 18780.1 21269.2 18635.199999999997 11973.4 18596.699999999997 True False 22071.925053253624 20105.931945537934 20650.708769135283 20677.221021159385 19356.59208255398 18591.189244966477 19664.847120068833 18140.93396033946 20317.985297463994 20983.76759219778 1.051857106035641 0.9581659660114495 0.9841277872717988 0.9853912520860947 0.9224555122194158 0.885979563168584 0.9371456786140088 0.8645222494307768 0.9682715560106882 1.0 14.356986113641247 -6.240728919448821 4.675186246418331 0.9208510367828314 0.9923561716390242 0.35157762642811474 0.04237022290669237 0.20168831803044626 11.868117908779798 0.012249014456015768 0.015333093756966511 5.744749295496749e-07 6.240728919448821 0.07150513485619281 VGDVT(ph)PQVK ddPTM_A459_Selumetinib_30min_R2 3 VGDVTPQVK 9 0 E7ETY2;Q13428-6;Q13428-7;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 VGDVT(1)PQVK;VGDVT(1)PQVK;VGDVT(1)PQVK 123.01 0.013479 76916000.0 543740.0 513240.0 504910.0 553640.0 535530.0 520710.0 514400.0 481820.0 432330.0 570910.0 True False 513521.10756368004 552603.857673292 472424.6403044423 478233.27691772976 468251.933701056 592433.0759652469 538320.619264263 483222.0164304056 518808.08030948834 554426.3448976789 0.9262206103471723 0.9967128415863369 0.8520963057620029 0.8625731466746753 0.844570136340605 1.068551452176361 0.9709506487531931 0.871571166986276 0.9357565438295252 1.0 19.08063628665618 -6.718203441938366 24.999932218444382 0.961439236488868 0.8976612583021989 0.2518819136152781 0.06207998641433177 251.25939569808125 145282.68982337238 0.0222101646970021 0.022210039342314632 1.9133594164277335e-07 6.718203441938366 -0.06377797818666908 VGEDEDGS(ph)DEEVVHNEDIHFEPIVSLPEVEVK ddPTM_A459_Selumetinib_30min_R1 7 VGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVK 32 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 VGEDEDGS(0.986)DEEVVHNEDIHFEPIVS(0.014)LPEVEVK;VGEDEDGS(0.995)DEEVVHNEDIHFEPIVS(0.005)LPEVEVK;VGEDEDGS(1)DEEVVHNEDIHFEPIVSLPEVEVK;VGEDEDGS(1)DEEVVHNEDIHFEPIVSLPEVEVK;VGEDEDGS(1)DEEVVHNEDIHFEPIVSLPEVEVK;VGEDEDGS(0.991)DEEVVHNEDIHFEPIVS(0.009)LPEVEVK;VGEDEDGS(0.991)DEEVVHNEDIHFEPIVS(0.009)LPEVEVK 72.053 4.0087e-05 249924000.0 29433.26 31765.010000000002 36929.380000000005 37642.68 26106.820000000003 28691.769999999997 27874.840000000004 28166.989999999998 17787.43 27144.51 True False 30118.997690845725 28045.947862047495 31914.57303456405 31069.09257861719 23745.46274053342 28403.15684384278 25772.218376637564 27419.909925922006 30183.969567513825 30628.77226841797 0.9833563496079832 0.9156732635661767 1.0419801601865675 1.0143760352631974 0.775266554350855 0.9273357937735534 0.8414381794601636 0.8952337261717572 0.9854776189849832 1.0 14.902599918286388 VGEDEDGS(ph)DEEVVHNEDIHFEPIVSLPEVEVK ddPTM_A459_Selumetinib_30min_R2 4 VGEDEDGSDEEVVHNEDIHFEPIVSLPEVEVK 32 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 VGEDEDGS(1)DEEVVHNEDIHFEPIVSLPEVEVK;VGEDEDGS(0.911)DEEVVHNEDIHFEPIVS(0.089)LPEVEVK;VGEDEDGS(1)DEEVVHNEDIHFEPIVSLPEVEVK;VGEDEDGS(0.957)DEEVVHNEDIHFEPIVS(0.043)LPEVEVK 75.083 9.618e-06 21819900.0 80914.7 69541.2 67649.7 72501.1 63897.4 52495.8 60439.8 68187.2 48407.3 59451.0 True False 76417.78490120806 74874.78642979878 63297.19195342424 62626.32510862647 55870.037361996234 59726.61994057426 63250.37045919169 68385.61346300143 58090.11261297033 57734.495157751495 1.3236070514240588 1.2968812877849512 1.0963496221881468 1.0847297605618398 0.9677063462551999 1.0345049311919947 1.0955386426497509 1.1844844797923189 1.0061595317365668 1.0 15.81714593625364 -5.278176822175845 2.8380826026220594 1.0592306853708766 1.3252344308913349 0.757234756303816 0.05744996600977427 0.13593064917217132 2.157356385850818 0.016492794654798085 0.04893517165496593 5.2701524447661276e-06 5.278176822175845 0.26600374552045825 VGEEEHVY(ph)SFPNK ddPTM_A459_Selumetinib_30min_R1 4 VGEEEHVYSFPNK 13 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 VGEEEHVY(0.596)S(0.404)FPNK;VGEEEHVY(0.969)S(0.031)FPNK;VGEEEHVY(0.952)S(0.048)FPNK;VGEEEHVY(0.989)S(0.011)FPNK 175.65 0.0013847999999999998 188010000.0 37687.4 38359.2 40923.0 41097.9 32700.0 35741.8 32782.8 29501.7 18900.4 25081.1 True False 38565.44309308515 33868.087031291725 35365.88137394848 33920.92326812945 29742.290773653887 35382.26994295788 30309.967002416313 28719.21908097292 32072.598369401214 28300.503495602523 1.3627122605460942 1.1967309004433198 1.2496555539884233 1.1985978720626034 1.0509456405351727 1.2502346450640272 1.071004514358765 1.0147953404940466 1.1332872001512206 1.0 14.78854009989096 -1.5228787453099633 0.18668608701433587 0.9950223231647621 2.4665303316615073 0.6510046883974325 0.06652360812176723 34.53148116614673 0.3988926774304627 0.13785936015539826 14.562682801197205 0.029999999997953528 1.5228787453099633 1.4715080084967451 VGEEEHVY(ph)SFPNK ddPTM_A459_Selumetinib_30min_R2 1 VGEEEHVYSFPNK 13 0 A0A1B0GTU4;F5GZ78;P49023;P49023-2;P49023-3;A0A1B0GU60;F5H836 A0A1B0GTU4 PXN Paxillin 1 VGEEEHVY(0.99)S(0.01)FPNK 173.19 0.0010189 58632000.0 165370.0 177050.0 181570.0 195200.0 178690.0 202100.0 181350.0 185180.0 145610.0 209170.0 True False 156179.397428561 190629.16569452191 169887.98387846898 168613.42326121792 156241.36469113163 229937.44051886155 189783.13433820757 185718.84314180055 174736.06868333064 203130.7186110729 0.7688615414569182 0.9384556260026469 0.8363480670973621 0.8300734837848726 0.7691666024688337 1.1319678386956062 0.934290665812976 0.9142824109109255 0.8602148895947713 1.0 17.632048903321035 -6.719168739642951 24.999998527919473 0.9606786697567525 0.8351996357216379 0.4323749470956808 0.07954795187493056 158.4441253909251 93707.61703402146 0.026655974326672723 0.026655768078991796 1.909111353310937e-07 6.719168739642951 -0.12547903403511462 VGEFCHNR ddPTM_A459_Selumetinib_30min_R1 4 VGEFCHNR 8 0 P22314;Q5JRR9;P22314-2;Q5JRS2;Q5JRS0 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 ;;; 153.04 0.0012876 24757000.0 23151.0 25827.0 27183.100000000002 29336.4 26005.9 21849.4 23057.699999999997 22771.9 14158.1 20648.100000000002 False True 23690.373255995768 22803.16283335344 23491.784326080167 24213.348452430728 23653.67093671456 21629.614873667917 21318.439125139234 22167.91523844413 24025.26163328923 23298.48476452592 1.0168203424141355 0.9787401654580278 1.008296658066303 1.039267089561883 1.0152450331332037 0.9283700245863623 0.9150139736811773 0.9514745470571035 1.0311941688959056 1.0 14.507948510661299 -6.741865074718446 24.992196220078245 0.9590404158075942 1.0111895596381808 0.30759424290313975 0.03423146123028901 288.01112531935235 367727.6141014698 0.011860265368383832 0.011843776784259782 1.8119029216449247e-07 6.741865074718446 0.05214914383058655 VGEFCHNR ddPTM_A459_Selumetinib_30min_R2 3 VGEFCHNR 8 0 P22314;Q5JRR9;P22314-2;Q5JRS2;Q5JRS0 P22314 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 ;; 162.25 0.00052817 16050500.0 98598.0 88201.0 95804.0 107260.0 104684.0 70425.0 82513.0 86992.0 72038.0 88542.0 False True 93118.31787906658 94965.7330890851 89640.0749435084 92651.00296617976 91532.66003316599 80125.40449550132 86350.01799640777 87245.13231769924 86447.61290989498 85985.56240025614 1.082952943258172 1.1044381223795101 1.0425014670049 1.0775181365319972 1.0645119654749542 0.9318471875839315 1.004238567335934 1.0146486210275616 1.0053735824566459 1.0 16.39180682073477 -6.615436198396999 8.779141198114393 0.9930663415812754 1.0756945662634798 0.7270690418737918 0.025546439991362427 0.15149968225341412 12.883832352618633 0.008629408192236915 0.008624559364570747 2.42417407046376e-07 6.615436198396999 0.08262822468220443 VGETFHAS(ph)QPS(ph)MTVDGFTDPS(ph)NSER ddPTM_A459_Selumetinib_30min_R2 2 VGETFHASQPSMTVDGFTDPSNSER 25 0 P84022;P84022-2;H0YNV1;H0YKE2;H3BVD1;P84022-4;P84022-3 P84022 SMAD3 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog 3 VGET(0.454)FHAS(0.581)QPS(0.947)MT(0.016)VDGFT(0.117)DPS(0.804)NS(0.08)ER;VGET(0.136)FHAS(0.871)QPS(0.976)MT(0.026)VDGFT(0.046)DPS(0.825)NS(0.12)ER 44.955 0.032787000000000004 222890000.0 12042.4 11064.0 27338.9 42274.8 43816.0 32702.3 19571.9 33331.8 40023.3 32851.6 True False 11373.13161754673 11912.573223632831 25579.944938343706 36516.89931190238 38311.44235999006 37206.74498307754 20482.03213098412 33428.79001962344 48029.0783444376 31903.088949292534 0.356489982384572 0.3733987402463421 0.8018015114148046 1.144619549848077 1.2008693710155498 1.166242712177957 0.6420078056873649 1.0478229889511919 1.505467963330324 1.0 14.961408496206603 -5.424449193339805 2.6036565148693533 1.0901083709982886 0.34790104158320584 0.6762190393876439 0.20221394023264586 0.1737567428485996 2.2615165980390444 0.05937013696326729 0.15077069705122853 3.7631437345382404e-06 5.424449193339805 -0.7422073294150828 VGFQY(ph)EGTYK ddPTM_A459_Selumetinib_30min_R2 1 VGFQYEGTYK 10 0 P11413-3;P11413;P11413-2 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 1 VGFQY(1)EGTYK 152.54 0.008806399999999999 3992700.0 13893.0 13130.0 18298.0 20371.0 16765.0 13545.0 13915.0 14347.0 13733.0 11732.0 True False 13120.882678085494 14137.028780395796 17120.72660135604 17596.434658064925 14658.830818998387 15410.700800732226 14562.075072049416 14388.747394726297 16479.9837320801 11393.266676603263 1.1516348252455102 1.2408231266478655 1.5027056846228701 1.5444591228782723 1.2866222862228924 1.352614771352539 1.2781299240500958 1.2629167562868011 1.4464669527943823 1.0 13.475893835326088 -10.99534831780943 2.902520038659762 0.9899163263817559 1.3431585900142107 0.4311718516365626 0.11736990865286612 22245046.8227079 25376029.37920455 1812659.7975946958 0.03316523623696927 1.0107684610429032e-11 10.99534831780943 0.3532422636324548 VGFQYEGTYK ddPTM_A459_Selumetinib_30min_R1 1 VGFQYEGTYK 10 0 P11413-3;P11413;P11413-2 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 0 133.23 0.031949 7850600.0 779.19 907.93 829.26 1018.5 711.27 700.79 757.23 843.43 375.1 588.19 False True 797.343610960189 801.6291335147944 716.6510467991228 840.6380946128601 646.9357540849181 693.7406888664096 700.1115314506291 821.0594965532486 636.5173037799414 663.689915955778 1.2013797283810417 1.2078368440484295 1.07979800441457 1.266612727424462 0.9747560397286853 1.0452783328301072 1.0548774580104934 1.2371131108280333 0.9590582717582722 1.0 9.374365543994742 -1.522878745318711 0.20986121232412575 1.0204484885583105 2.02606384244663 0.29188833774249 0.09194424614401961 73.0755887980768 0.9093008785794876 0.155429599165791 24.52073424155361 0.02999999999734926 1.522878745318711 1.0056153538883195 VGGPLAVLGPS(ph)RSSEDLAGPLPSSVSSSSTTSSKPK ddPTM_A459_Selumetinib_30min_R1 1 VGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPK 36 2 Q9NRF2-2;Q9NRF2-3;Q9NRF2 Q9NRF2-2 SH2B1 SH2B adapter protein 1 1 VGGPLAVLGPS(0.333)RS(0.333)S(0.333)EDLAGPLPSSVSSSSTTSSKPK 57.95 0.00015877 17792000.0 623.31 595.94 1569.9 1858.5 1175.5 1024.4 627.85 956.28 424.09 386.65 True False 637.8319102498691 526.1670677550103 1356.71620284343 1533.9478633657345 1069.1762325513819 1014.095466080781 580.4907690150653 930.9163479647876 719.6497556919097 436.2802937899346 1.4619773556790074 1.2060298740157065 3.109735237082878 3.5159687136919318 2.4506635934974903 2.3244127239197736 1.3305454710603246 2.1337574976811036 1.6495124027729182 1.0 8.76911150031334 -7.193695849425428 7.133785619701773 1.6241218668226696 2.389005215625184 0.24467162913324003 0.6921979228947793 0.47339944379701865 43.285378348731534 0.29594594403170227 0.22834957176901655 6.401830195505145e-08 7.193695849425428 0.7648833488025144 VGGS(ph)DEEASGIPSR ddPTM_A459_Selumetinib_30min_R1 10 VGGSDEEASGIPSR 14 0 H7C446;A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3 H7C446 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 1 VGGS(0.971)DEEAS(0.029)GIPSR;VGGS(0.88)DEEAS(0.12)GIPSR;VGGS(0.998)DEEAS(0.002)GIPSR;VGGS(1)DEEASGIPSR;VGGS(0.981)DEEAS(0.019)GIPSR;VGGS(1)DEEASGIPSR;VGGS(1)DEEASGIPSR;VGGS(0.985)DEEAS(0.015)GIPSR;VGGS(0.994)DEEAS(0.003)GIPS(0.003)R;VGGS(1)DEEASGIPSR 201.76 5.4917e-05 1096185300.0 8834.25 10366.099999999999 10208.83 11804.930000000002 11077.789999999999 9389.58 10402.15 9195.99 5637.04 7445.799999999999 True False 9040.070836541854 9152.432192930846 8822.526959089178 9743.420581480794 10075.80585044267 9295.129350256515 9617.50745068099 8952.082472414675 9565.645166887974 8401.540958233789 1.0760015194215395 1.0893754179655768 1.050108188836812 1.1597182742925176 1.199280691546001 1.106360059001674 1.144731365173613 1.0655286353917417 1.13855841618118 1.0 13.036438246947897 -10.666653287773494 14.659303931967615 1.0000000083724956 1.1148261863404851 0.37716081411108704 0.04410310746335364 0.0 0.0 0.045208292841041615 0.010964621561027607 2.1545010606553818e-11 10.666653287773494 0.11482617796798955 VGGS(ph)DEEASGIPSR ddPTM_A459_Selumetinib_30min_R2 6 VGGSDEEASGIPSR 14 0 H7C446;A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3 H7C446 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 1 VGGS(1)DEEASGIPSR;VGGS(0.995)DEEAS(0.005)GIPSR;VGGS(1)DEEASGIPSR;VGGS(1)DEEASGIPSR;VGGS(1)DEEASGIPSR;VGGS(0.999)DEEAS(0.001)GIPSR 244.23 5.3012e-20 1187483300.0 394617.0 323662.7 382614.0 436304.0 414334.0 322886.8 336628.0 329409.9 288618.3 397119.0 True False 372685.7669170131 348486.5883503886 357997.03179862513 376878.64253361966 362281.65872704267 367361.5258254607 352281.8690157275 330368.42827225535 346350.02466909046 385653.14263092575 0.9663755476606538 0.9036269897167519 0.9282876041314466 0.977247689368103 0.9393976573237733 0.952569771166184 0.913468166271019 0.8566465348071117 0.898086872328566 1.0 18.55694434168784 -7.376420759307337 5.34503369106089 0.90399684682252 0.9431124097688947 0.07302899531583873 0.03886715176195143 0.4024310275908921 16.20006703943753 0.0161439898437608 0.010714877097377718 4.203192114679498e-08 7.376420759307337 0.03911556294637464 VGGS(ph)SVDLHR ddPTM_A459_Selumetinib_30min_R1 4 VGGSSVDLHR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 VGGS(0.726)S(0.274)VDLHR;VGGS(0.947)S(0.053)VDLHR;VGGS(0.693)S(0.307)VDLHR;VGGS(0.693)S(0.307)VDLHR 148.28 0.00079251 203594000.0 16658.7 19295.7 18325.6 18523.5 17704.4 16151.900000000001 19410.7 15097.7 7613.0 13064.7 True False 17046.815297812478 17036.550473672436 15837.084175315338 15288.718454159369 16103.04014596569 15989.426550751814 17946.535271355766 14697.259951758879 12918.704968479593 14741.68150595463 1.1563684435134982 1.1556721305361832 1.0743064940670601 1.0371081784655145 1.0923475818861752 1.0846406187986886 1.2174008279928308 0.9969866697921939 0.8763386295695861 1.0 13.847613473992057 -7.968577266351802 9.068457326057702 0.937552270830109 1.1113085735162287 0.6415634419304115 0.05554279287018468 0.1658344436199839 44.745467431891534 0.031276572956832935 0.014870486788792643 1.0750353213175897e-08 7.968577266351802 0.17375630268611975 VGGS(ph)SVDLHR ddPTM_A459_Selumetinib_30min_R2 7 VGGSSVDLHR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 VGGS(0.838)S(0.162)VDLHR;VGGS(0.84)S(0.16)VDLHR;VGGS(0.955)S(0.045)VDLHR;VGGS(0.5)S(0.5)VDLHR;VGGS(0.709)S(0.291)VDLHR;VGGS(0.988)S(0.012)VDLHR;VGGS(0.862)S(0.138)VDLHR 116.71 0.0041339 141348900.0 462459.0 380612.0 458808.0 444414.0 512481.0 522863.0 391349.0 415459.0 385736.0 461898.0 True False 436757.3801500572 409803.71653952793 429288.7927923795 383884.0465430892 448098.5551417308 594882.6321722594 409547.503943332 416667.9169070604 462893.97836435284 448561.8045848698 0.973683839519646 0.9135947652047385 0.9570337652571046 0.8558108216511259 0.9989672561542156 1.3261999262795123 0.9130235783725626 0.9288974510272309 1.0319513913868503 1.0 18.774947253394174 -6.514100601353206 24.99271933368572 1.042628045343865 0.9266109982426621 0.19640931732348443 0.10972675300773996 746.9211181505151 2126604.4653501976 0.03696954730020201 0.038876196877807294 3.0612542328993363e-07 6.514100601353206 -0.11601704710120286 VGGSS(ph)VDLHR ddPTM_A459_Selumetinib_30min_R1 2 VGGSSVDLHR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 VGGS(0.182)S(0.818)VDLHR;VGGS(0.182)S(0.818)VDLHR 182.71 6.9706e-05 35253000.0 7490.9 8059.200000000001 9294.4 10371.7 8910.099999999999 7667.6 7501.9 7615.9 3956.5 7017.6 True False 7665.423395245932 7115.625117379568 8032.271530484726 8560.477295921648 8104.18302820592 7590.470905623776 6936.025643185661 7413.901592070338 6713.891528673251 7918.377317212579 0.9680548284284473 0.8986216281853572 1.0143835294416406 1.081089843661946 1.0234651246776842 0.9585891908843475 0.8759402798485579 0.9362905169919553 0.8478872955547248 1.0 12.9509890992771 -7.018839708756198 5.4750526903677645 0.9101922480380883 0.9969979220695528 0.3144633231663375 0.05693041560999865 0.2238093359192099 21.246995777970437 0.022677213914333357 0.018404133185954283 9.575474217342153e-08 7.018839708756198 0.08680567403146455 VGGSS(ph)VDLHR ddPTM_A459_Selumetinib_30min_R2 1 VGGSSVDLHR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 1 VGGS(0.226)S(0.774)VDLHR 113.67 0.007486 10270000.0 47233.0 36481.0 39969.0 43170.0 37867.0 28726.0 39747.0 40940.0 34487.0 36798.0 True False 44607.97894868009 39278.97539509663 37397.43805495682 37290.171527596205 33109.80892472485 32682.7457513351 41595.31425718636 41059.12862201813 41385.363647290964 35735.54612731394 1.2482803198181611 1.0991569921768827 1.0465052897672842 1.0435036138735267 0.9265230985071712 0.9145724437762133 1.1639758941697995 1.1489716282979985 1.158100774501909 1.0 15.125072215930981 -10.777592982769045 14.838434445971092 1.0000100349915382 1.0762346801595855 0.05461471622517433 0.1001597583785282 0.0 0.0 0.10594792085261438 0.025696145205288772 1.668810475405707e-11 10.777592982769045 0.07622464516804728 VGGSSVDLHR ddPTM_A459_Selumetinib_30min_R2 2 VGGSSVDLHR 10 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6;O60716-19;O60716-11;O60716-13;O60716-21;O60716-24;O60716-9;O60716-17;O60716-16;O60716-10;O60716-23;O60716-15;O60716-18;O60716-12;O60716-22;O60716-20;O60716-14 O60716-5 CTNND1 Catenin delta-1 0 ; 151.22 0.00095595 2496600.0 41075.0 34237.0 45789.0 53102.0 58229.0 39150.0 39373.0 41735.0 44834.0 47349.0 False True 38792.215936252906 36862.867810693875 42842.98559129371 45869.41599394059 50913.75244613519 44542.557131684516 41203.92251611941 41856.441940398814 53802.05276662633 45981.9113425237 0.843640788380586 0.8016819382756583 0.9317356399596392 0.9975534868973774 1.1072561135372065 0.968697381887471 0.8960898169105544 0.9102806020525361 1.1700699513304187 1.0 15.488778815746235 -5.4678940074483995 2.9940349438826686 1.0008514812069291 0.8226867148807148 0.4650121414174151 0.07836403866534569 0.24385791002301085 4.282727875874411 0.02253986696327319 0.051471416612864376 3.4049127879687775e-06 5.4678940074483995 -0.17816476632621436 VGGTSDVEVNEK ddPTM_A459_Selumetinib_30min_R1 2 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 ; 174.77 0.0017921 15339600.0 3245.3 3991.6 3531.8999999999996 3394.8999999999996 4132.7 3899.1000000000004 3438.3 3275.5 2080.23 2810.5 False True 3320.909175745456 3524.2616163555044 3052.287379337991 2802.0444451656326 3758.898014687445 3859.878594099546 3178.946262808789 3188.623099676519 3529.9983760121204 3171.2550515882835 1.0471908193200103 1.1113144666779236 0.9624856183703329 0.8835758712508045 1.1853029647693736 1.2171454302189835 1.002425289387132 1.0054767112091905 1.1131234538338897 1.0 11.630838197065787 -4.42533015331089 15.333502338739011 1.0546311338056427 0.8146376724591505 0.0002288724342689452 0.097978182776261 8990519.535436733 17662503.036356922 0.025982236364395613 72900127.24085903 3.755517989772842e-05 4.42533015331089 -0.23999346134649213 VGGTSDVEVNEK ddPTM_A459_Selumetinib_30min_R2 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 157.68 0.0061905 5338800.0 18961.0 13390.0 17950.0 23452.0 15763.0 12127.0 24258.0 19042.0 17379.0 16763.0 False True 17907.223526896927 14416.969944364024 16795.1165424823 20257.797143043466 13782.711016992038 13797.384172054606 25386.045066315088 19097.409067427197 20855.285609831808 16279.008634495434 1.100019290422347 0.8856171937776527 1.0317038905485454 1.2444122119400396 0.8466554276398804 0.8475567819785885 1.55943433880376 1.173130962469025 1.2811152127310248 1.0 13.990725224015657 -7.240965646434156 24.999077187134173 1.2678477656050946 0.994376510365889 0.3540423356931286 0.1721017912959308 872.4184288301808 1065252.0234352208 0.06495027204192375 0.05024921672788318 5.741618777688678e-08 7.240965646434156 -0.27347125523920557 VGGVSPEEHPAPEVS(ph)TPFPPLPPEPEGGGEEK ddPTM_A459_Selumetinib_30min_R1 1 VGGVSPEEHPAPEVSTPFPPLPPEPEGGGEEK 32 0 Q8TE77;Q8TE77-3 Q8TE77 SSH3 Protein phosphatase Slingshot homolog 3 1 VGGVS(0.187)PEEHPAPEVS(0.407)T(0.407)PFPPLPPEPEGGGEEK 67.911 0.00012575 8693200.0 1519.8 2217.9 1370.2 1665.4 1403.3 1655.1 1504.2 1635.4 914.25 1364.1 True False 1555.208382983991 1958.2272369262644 1184.1343659698507 1374.569153429806 1276.3717627727374 1638.4511967105627 1390.7369829616325 1592.0238794721358 1551.4154758219447 1539.195522459199 1.0104033959890995 1.2722407311824628 0.7693203031658635 0.8930438877795287 0.8292460211510078 1.0644854229388487 0.9035479655889515 1.0343220573618432 1.0079391819846393 1.0 10.587960792069202 -5.255161216833625 24.999377321159113 0.9367985668969405 1.1413220507436432 0.3723169571588384 0.10572899192819929 519.4754323032179 2068514.9315282344 0.026893338429913496 0.06755913214048477 5.5569793530322816e-06 5.255161216833625 0.2045234838467027 VGIDT(ph)PDIDIHGPEGK ddPTM_A459_Selumetinib_30min_R1 2 VGIDTPDIDIHGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VGIDT(1)PDIDIHGPEGK;VGIDT(1)PDIDIHGPEGK 157.42 0.00010362 29610100.0 12693.9 12098.4 13515.4 12860.099999999999 11624.8 10813.5 9717.6 10628.6 8683.400000000001 11601.5 True False 12989.643171970305 10681.913703606439 11680.082914778077 10614.324948974798 10573.338892525138 10704.726007872438 8984.593608315356 10346.695001441572 14735.095589556764 13090.665533179681 0.9922828704962843 0.8159947006920308 0.8922451563042129 0.8108315747638395 0.8077006372002927 0.8177373396898862 0.6863358922083029 0.7903872400694049 1.125618522007846 1.0 13.676250825725653 -8.256961180743764 24.998067191859484 1.0628092725717668 0.822379713354631 0.5911952369766516 0.07847348372835991 238.53388518651593 1331555.4811136315 0.05848285300258785 0.020392097525170027 5.533995724270403e-09 8.256961180743764 -0.24042955921713582 VGIDT(ph)PDIDIHGPEGK ddPTM_A459_Selumetinib_30min_R2 4 VGIDTPDIDIHGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VGIDT(1)PDIDIHGPEGK;VGIDT(1)PDIDIHGPEGK;VGIDT(1)PDIDIHGPEGK;VGIDT(1)PDIDIHGPEGK 187.75 1.1904e-06 30362400.0 140041.7 121874.6 138842.4 161989.1 152566.6 111051.9 157978.0 130282.8 104446.1 126450.4 True False 132258.7429453425 131221.98993139554 129909.43114417524 139925.9051332158 133399.8197452907 126348.29119622262 165324.29002746832 130661.9013785215 125338.2384678669 122799.44839440427 1.0770304319328625 1.0685877798892056 1.0578991424044129 1.1394668865596627 1.0863226300238777 1.0288995011640465 1.346295054164118 1.064026777700701 1.0206742791328232 1.0 16.905944554685256 -5.739440812518083 24.428627007496914 1.107608317610634 1.0679139710645706 0.014376630501204968 0.09265785364795091 791.582537055989 879014.1248500029 0.025434675158885332 0.04400131497834992 1.82204537219247e-06 5.739440812518083 -0.0396943465460633 VGINYQPPTVVPGGDLAK ddPTM_A459_Selumetinib_30min_R1 2 VGINYQPPTVVPGGDLAK 18 0 Q9BQE3;F5H5D3;A0A1W2PQM2;Q9NY65;Q9NY65-2;C9J2C0;V9GZ17;P68363;P68363-2;P68366-2;P68366 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA8;TUBA1B;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 218.16 4.1391999999999997e-13 28358000.0 4249.8 5183.6 5049.2 5051.8 5021.5 4528.1 4647.6 4472.5 3333.6 4010.0 False True 4348.812071328704 4576.70170220974 4363.546373270304 4169.597964030676 4567.3062116178335 4482.5514251858485 4297.027790195775 4353.874771272547 5656.875723489234 4524.7225607077135 0.9611223700417347 1.0114878074411475 0.964378769023973 0.9215146140095068 1.0094113286149107 0.9906798405966202 0.9496776283060492 0.9622412673610548 1.2502149353007932 1.0 12.143613618833152 -8.227182369250038 24.870467027878185 1.1251075252714637 0.9719563425691795 0.4994103773289076 0.06158720135671441 370.5323056880727 269005.8360784392 0.037952974574194484 0.014343127518127427 5.9267639522179234e-09 8.227182369250038 -0.15315118270228423 VGINYQPPTVVPGGDLAK ddPTM_A459_Selumetinib_30min_R2 2 VGINYQPPTVVPGGDLAK 18 0 Q9BQE3;F5H5D3;A0A1W2PQM2;Q9NY65;Q9NY65-2;C9J2C0;V9GZ17;P68363;P68363-2;P68366-2;P68366 Q9BQE3;P68363;P68366-2 TUBA1C;TUBA8;TUBA1B;TUBA4A Tubulin alpha-1C chain;Tubulin alpha-8 chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 ; 152.0 0.0014606 21975200.0 194917.0 162536.0 214625.0 198942.0 216273.0 162206.0 182988.0 180468.0 152544.0 198664.0 False True 184084.29345457355 175001.9885643879 200816.26116603092 171845.75640590824 189102.85223484848 184548.4041405366 191497.3045838433 180993.13200191443 183057.06243547867 192928.05412893902 0.9541603178744811 0.9070841944398057 1.0408867806846795 0.8907245614526288 0.9801729099929963 0.9565659332115479 0.9925840254204839 0.9381379645334101 0.9488358925402145 1.0 17.557703418808153 VGLVEDSPSTAGDGDDSPVVSLTVPSTS(ph)PPSSSGLSR ddPTM_A459_Selumetinib_30min_R1 1 VGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSR 37 0 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 VGLVEDSPSTAGDGDDSPVVSLTVPS(0.008)T(0.102)S(0.884)PPS(0.005)SSGLSR 181.44 7.8175e-51 4406600.0 3277.3 3716.9 3719.9 3830.5 4047.4 3318.8 3399.7 2977.9 1982.6 2789.4 True False 3353.6547134842967 3281.7236200600696 3214.7580119480717 3161.5750823903377 3681.3133846265096 3285.4158852293012 3143.2578918858258 2898.916418417559 3364.3273966251986 3147.446661056881 1.0655159799779332 1.0426621873103006 1.0213860179821406 1.0044888517121724 1.169618989949892 1.043835285877757 0.9986691532463814 0.921037504554289 1.0689068819661875 1.0 11.619966213843627 -7.239547488061557 4.716056131850471 0.9900259246313472 1.0587652039934474 0.23824288502055968 0.05306755423709543 0.2793400784099738 16.8139156678141 0.02180124216663142 0.015924154538886424 5.7603982786674145e-08 7.239547488061557 0.06873927936210023 VGLVEDSPSTAGDGDDSPVVSLTVPSTS(ph)PPSSSGLSR ddPTM_A459_Selumetinib_30min_R2 1 VGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSR 37 0 Q6VY07-2;Q6VY07;B4DF77 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 VGLVEDSPSTAGDGDDS(0.007)PVVS(0.021)LT(0.002)VPS(0.131)T(0.131)S(0.656)PPS(0.03)S(0.01)S(0.01)GLS(0.002)R 84.789 2.2999e-09 4346900.0 7058.9 5360.0 6142.3 8303.7 7891.6 5528.8 6542.3 6009.0 5695.4 5761.4 True False 6666.594597015597 5771.094764883585 5747.111105230589 7172.721735318526 6900.186656200872 6290.342014550635 6846.529913321518 6026.485195156497 6834.639142772082 5595.053412085068 1.191515809771547 1.0314637483921558 1.027177165604368 1.2819755607383059 1.2332655558384436 1.1242684477263032 1.223675523549662 1.0771095021433674 1.2215502944099808 1.0 12.449936188336043 -10.604402820296697 4.229950663714113 0.9999844121756546 1.1539688331252738 0.23621103719931835 0.08448836431382055 62278518.9738376 34016372.65741858 13197.448540708869 0.021878228909865488 2.4865499036672387e-11 10.604402820296697 0.15398442094961917 VGMADANS(ph)PPKPLSKPR ddPTM_A459_Selumetinib_30min_R1 1 VGMADANSPPKPLSKPR 17 2 P26358;P26358-2;K7EJL0 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 VGMADANS(0.979)PPKPLS(0.021)KPR 54.834 0.031601 22508000.0 3878.3 7349.7 5751.9 6256.1 4510.3 4987.3 5197.8 4297.6 2922.3 4359.2 True False 3968.6568441418663 6489.193707217166 4970.823572925107 5163.5895765414925 4102.344161358143 4937.1322901060885 4805.7257612272115 4183.6136874278145 4958.929663652689 4918.745782203753 0.806843252298309 1.3192781238451812 1.0105876158328357 1.049777688292734 0.8340223998159472 1.0037380480139588 0.9770225935673575 0.8505448081021629 1.0081695381766471 1.0 12.264074778180033 -6.069458465251775 11.816838261823365 0.9424684968546655 1.0658382448873729 0.12199144286555219 0.1292856934218206 1.7910431746792805 302.09409100674503 0.03606837108528371 0.046592031153936786 8.522000095832818e-07 6.069458465251775 0.1233697480327074 VGNES(ph)PVQELK ddPTM_A459_Selumetinib_30min_R1 4 VGNESPVQELK 11 0 Q5JSH3-2;Q5JSH3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 VGNES(1)PVQELK;VGNES(1)PVQELK;VGNES(1)PVQELK;VGNES(1)PVQELK 228.62 4.1113e-07 273412000.0 19277.699999999997 21684.7 19139.899999999998 20321.2 17215.3 17552.4 20531.8 18356.100000000002 11295.2 17320.899999999998 True False 19726.83290212558 19145.84524305646 16540.806707945074 16772.483896167752 15658.17915460807 17375.83879230408 18983.069795752977 17869.23659898402 19167.129431232173 19544.206234853416 1.0093442867455258 0.9796174381803978 0.8463278840379639 0.8581818926090322 0.8011673109898243 0.889053184534941 0.9712888601175443 0.9142984055866948 0.9807064661982129 1.0 14.25445337198965 -8.044665229097207 1.1597496377388772 0.9959348588747765 0.8968861651101537 0.23179267956619298 0.060953159639005806 0.784224589142396 1.9395726190043883 0.0625612477741899 0.021648946045318897 9.022663712626083e-09 8.044665229097207 -0.09904869376462277 VGNES(ph)PVQELK ddPTM_A459_Selumetinib_30min_R2 4 VGNESPVQELK 11 0 Q5JSH3-2;Q5JSH3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 VGNES(1)PVQELK;VGNES(1)PVQELK;VGNES(1)PVQELK;VGNES(1)PVQELK 183.81 2.8748000000000007e-05 267246000.0 963070.0 881710.0 866440.0 877210.0 916420.0 668360.0 760870.0 801070.0 589656.0 822170.0 True False 909546.4248746694 949334.3218555022 810694.193708544 757732.4847283447 801291.1267012533 760420.5232319958 796251.9626353016 803400.9810757233 707603.6763652099 798431.8158457997 1.1391660587963457 1.1889986133003072 1.0153580776960327 0.949025915163036 1.0035811584642638 0.9523925626967437 0.9972698317286005 1.0062236563364644 0.8862418334565322 1.0 19.606809684651594 -5.366286933663672 4.040647071454884 0.973228034974212 1.16410099591728 0.8101293492768616 0.03678772619912768 0.0833928759929903 2.3543569331506404 0.009352964448566422 0.021157441955851664 4.302422601638345e-06 5.366286933663672 0.19087296094306794 VGPAT(ph)PSAQVGK ddPTM_A459_Selumetinib_30min_R1 1 VGPATPSAQVGK 12 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 VGPAT(0.5)PS(0.5)AQVGK 125.84 0.0065943 26437000.0 4131.5 5012.8 3434.5 3278.3 4321.4 3437.6 5209.9 4581.6 2501.5 4509.0 True False 4227.755911500431 4425.899045612506 2968.1137643580887 2705.8064463125547 3930.530133005137 3403.0208650910695 4816.913048485447 4460.081084865806 4244.862797668685 5087.774071379317 0.8309637676883455 0.8699087230523633 0.583381597279421 0.5318251967070934 0.7725441573980021 0.6688624175028464 0.9467623720916446 0.876627189472794 0.8343261194610956 1.0 12.312818892128389 -7.260463296043581 24.97679802914732 0.904147857657679 0.705914417156386 0.4760238952879774 0.1050244236627433 89.3100561060607 2285380.024156886 0.045335682832908876 0.033059250381747736 5.4895494801570493e-08 7.260463296043581 -0.198233440501293 VGPAT(ph)PSAQVGK ddPTM_A459_Selumetinib_30min_R2 3 VGPATPSAQVGK 12 0 E7ETY2;Q13428-6;Q13428-7;A0A3B3IS06;H0Y8Y7;Q13428-5;Q13428;Q13428-3;Q13428-4;Q13428-2;Q13428-8;A0A6I8PRA0 E7ETY2;Q13428 TCOF1 Treacle protein 1 VGPAT(0.921)PS(0.079)AQVGK;VGPAT(0.867)PS(0.133)AQVGK;VGPAT(0.768)PS(0.232)AQVGK 120.6 0.0093345 187029000.0 555396.0 433968.0 569521.0 682040.0 675228.0 509940.0 549893.0 622470.0 557161.0 543578.0 True False 524529.3137463449 467251.950172948 532878.6389075802 589144.9754153754 590399.8220250907 580179.6062255733 575464.1140923076 624281.2846445448 668608.76837905 527883.4907547445 0.9936459899444782 0.8851421920865375 1.0094625958953438 1.1160511471443102 1.1184282751123038 1.0990675336257594 1.0901347061821056 1.1826118747376908 1.266583971821325 1.0 19.00986002171321 -5.648718606456949 2.8721801160853264 1.1311504046605605 0.9389831233647304 0.549941153198875 0.06882049775488343 0.1852645271063014 3.0572206249552893 0.019720904887426286 0.038131082938835714 2.245336279092446e-06 5.648718606456949 -0.19216728129583005 VGPCS(ph)SPPAAR ddPTM_A459_Selumetinib_30min_R2 1 VGPCSSPPAAR 11 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1 Q8TDM6-4 DLG5 Disks large homolog 5 1 VGPCS(0.5)S(0.5)PPAAR 104.43 0.011365 0.0 31180.0 23212.0 31010.0 26432.0 28850.0 27577.0 23368.0 24455.0 22338.0 31892.0 True False 29447.140423429475 24992.285761656283 29014.850361135163 22831.91600225675 25225.60507772761 31375.48143091862 24454.65830281357 24526.160001256798 26806.22417586874 30971.195094632756 0.9507912217611714 0.8069525791721028 0.9368334115774363 0.7371984171903483 0.8144860087139213 1.013053624022275 0.7895936281468038 0.7919022797253029 0.8655211429188344 1.0 14.91863943333485 VGPCSS(ph)PPAAR ddPTM_A459_Selumetinib_30min_R1 2 VGPCSSPPAAR 11 0 Q8TDM6-4;Q8TDM6;Q8TDM6-2;A0A0J9YYG8;A0A0A0MSL1 Q8TDM6-4 DLG5 Disks large homolog 5 1 VGPCS(0.16)S(0.84)PPAAR;VGPCS(0.261)S(0.739)PPAAR 105.2 0.01183 84616000.0 5783.1 6488.9 6395.799999999999 7353.2 6516.5 6062.0 6214.9 5927.9 3479.9 5102.8 True False 5917.834978046262 5729.176571392228 5527.285489614628 6069.101656659089 5927.0837255815195 6001.021783855613 5746.105089355306 5770.672835467086 5905.136138160005 5757.794085481124 1.027795522067852 0.9950297781296038 0.959965814608107 1.0540671594982807 1.0294018225707788 1.0422432089031826 0.9979698829183049 1.002236750706045 1.0255900177205746 1.0 12.49130047975183 -5.764265773051906 24.999996974017943 1.0219324200772057 0.9943403176738579 0.23032909914894695 0.022932138539813747 112.58787520162674 995875.3981848278 0.006634285652944617 0.010363633123536782 1.7208151739225972e-06 5.764265773051906 -0.027592102403347862 VGQQAIVLCIS(ph)PSKPNPVFK ddPTM_A459_Selumetinib_30min_R1 1 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 1 VGQQAIVLCIS(0.982)PS(0.018)KPNPVFK 76.21 0.0031745 32031000.0 2004.9 2322.9 2503.0 2912.7 2033.0 2298.8 1794.8 2194.2 1082.2 1429.5 True False 2051.610269143705 2050.9337881130878 2163.1063479948443 2404.0516231505912 1849.1155089553015 2275.6761591434006 1659.416790998231 2136.0026882339234 1836.414359239275 1612.9902495091467 1.271929740287045 1.2715103446764249 1.3410535796190368 1.490431590570479 1.146389762441534 1.4108430970589672 1.0287829027504738 1.324250217187572 1.1385154744724086 1.0 10.655522002121968 -8.46332297124837 0.4526565624535627 0.9916847457365556 1.332185448841186 0.39820880712698603 0.11827207137564501 1.1672636567353134 0.6184663291839027 0.14744323787850952 0.0768968516627715 3.4409394366636252e-09 8.46332297124837 0.3405007031046303 VGQQAIVLCISPS(ph)KPNPVFK ddPTM_A459_Selumetinib_30min_R1 1 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 1 VGQQAIVLCIS(0.206)PS(0.794)KPNPVFK 78.531 0.0026691 31486000.0 3569.2 3852.8 4624.5 4579.7 3760.6 3943.7 3880.9 3938.5 2361.9 3372.0 True False 3652.355415545769 3401.712384881874 3996.5183005601884 3779.9413666161167 3420.454393987856 3904.0299585931025 3588.1605884694827 3834.0381859490067 4007.971793649277 3804.8290460614485 0.9599262861301189 0.8940513078775881 1.0503805170161762 0.9934589230832607 0.8989771557617086 1.0260723704877992 0.9430543514652125 1.0076768599939578 1.0533907687122266 1.0 11.893615918432952 -7.946851387080086 5.97160036303832 1.0280858179674968 0.9679141333203035 0.21357605479546293 0.048130269083302014 0.2830961081694701 21.68406134424506 0.02707580148427298 0.012599703645525012 1.1301825900914987e-08 7.946851387080086 -0.060171684647193246 VGQQAIVLCISPS(ph)KPNPVFK ddPTM_A459_Selumetinib_30min_R2 2 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 1 VGQQAIVLCIS(0.182)PS(0.818)KPNPVFK;VGQQAIVLCIS(0.207)PS(0.793)KPNPVFK 96.579 0.00054312 17779900.0 51533.0 44631.0 45029.0 46172.0 41544.0 35153.0 38807.0 39139.0 36136.0 41228.0 True False 48669.00216294393 48054.05418871626 42131.88316386827 39883.29394885738 36324.87131192774 39995.00666283793 40611.60239461169 39252.88801018973 43364.20972420059 40037.640516791645 1.2155811764814743 1.2002219303748072 1.0523068447602026 0.9961449634408519 0.9072680318585011 0.9989351556834165 1.0143355570011507 0.9803996315349104 1.0830860451432895 1.0 15.289069335865618 -5.342921883677341 2.562375948270017 0.9938427334198938 1.2182937411038566 0.8097168417014873 0.04029093324208854 0.11850312472184715 1.4869578187437396 0.01156248850680213 0.03297558078819827 4.540232742364081e-06 5.342921883677341 0.22445100768396276 VGS(ph)AQPSPPDDLDAGGLAQR ddPTM_A459_Selumetinib_30min_R1 2 VGSAQPSPPDDLDAGGLAQR 20 0 Q8N3D4;E9PIH6;H0YDZ9;A0A0U1RQH4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 VGS(0.929)AQPS(0.071)PPDDLDAGGLAQR;VGS(0.947)AQPS(0.053)PPDDLDAGGLAQR 178.1 3.6406e-13 3023500.0 2462.14 2959.4 2856.7 2975.3999999999996 3282.2000000000003 2667.86 2788.1099999999997 2424.34 1463.28 2135.09 True False 2519.5030715095413 2612.912072212266 2468.775830729873 2455.80224517536 2985.3255895194743 2641.023750623068 2577.80061797976 2360.0386278338506 2483.079286257299 2409.1495990377616 1.0458059858615072 1.084578588750109 1.0247499083145053 1.0193647775780432 1.2391615658537116 1.096247303064085 1.0700043778972295 0.9796148104611161 1.0306870471012117 1.0 11.23430826690131 -7.650957977050962 5.404406819512078 1.0043721987060843 1.0859386893383451 0.27780443983596903 0.05895309962527016 0.2973046970397624 12.8866527422079 0.0305888733633694 0.01719280046133632 2.2337883568981436e-08 7.650957977050962 0.08156649063226085 VGS(ph)AQPSPPDDLDAGGLAQR ddPTM_A459_Selumetinib_30min_R2 2 VGSAQPSPPDDLDAGGLAQR 20 0 Q8N3D4;E9PIH6;H0YDZ9;A0A0U1RQH4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 VGS(0.997)AQPS(0.003)PPDDLDAGGLAQR;VGS(0.597)AQPS(0.403)PPDDLDAGGLAQR 161.96 6.2243e-07 6964300.0 32875.0 27702.0 41113.0 33306.0 34556.0 23847.8 25669.0 27715.0 21414.0 33233.0 True False 31047.939109052077 29826.654324030802 38467.83434044984 28769.665343945333 30214.766345440374 27132.617981225685 26862.659362158563 27795.646061534753 25697.398357151647 32273.47694029632 0.962026470419924 0.9241847223095309 1.19193337648784 0.8914337118732886 0.9362104492594827 0.8407094789141911 0.8323447582624149 0.8612535337594631 0.7962389179415047 1.0 14.978061392586834 -5.968017932861092 24.999059416092997 0.8710100654676707 1.0201655770703795 0.3862265217863914 0.0843120372893486 194.1975435271107 151795.00233618647 0.023441250668602188 0.034768699590631 1.0764207652119884e-06 5.968017932861092 0.1491555116027088 VGS(ph)GSLDNLGR ddPTM_A459_Selumetinib_30min_R2 2 VGSGSLDNLGR 11 0 A0A2R8Y7R9;Q13136-2;Q13136;H0YDW2 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VGS(0.933)GS(0.067)LDNLGR;VGS(0.604)GS(0.396)LDNLGR 96.371 0.020298 11757400.0 28320.0 42278.0 36253.0 34416.0 34153.0 26491.0 30542.0 25627.0 18332.5 42915.0 True False 26746.087773942367 45520.586654803745 33920.521449281936 29728.48142908854 29862.39480830612 30139.894788645066 31962.263517824857 25701.57032722176 21999.51225284777 41675.93244343924 0.641763392102648 1.0922511863791482 0.8139115182441902 0.7133249260693745 0.716538132622085 0.7231966514378441 0.7669237769593433 0.616700546822865 0.5278709068526433 1.0 15.346926857500835 -5.629893741555299 4.301911053381883 0.7093664042639521 0.8852281596883567 0.12179713495362354 0.15248094190630632 0.3366720950605383 10.992486498033289 0.04011469106467332 0.07230213156253318 2.3448024458715925e-06 5.629893741555299 0.17586175542440452 VGS(ph)LDNVGHLPAGGAVK ddPTM_A459_Selumetinib_30min_R1 3 VGSLDNVGHLPAGGAVK 17 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VGS(1)LDNVGHLPAGGAVK;VGS(1)LDNVGHLPAGGAVK;VGS(1)LDNVGHLPAGGAVK 149.95 0.00027808 330152000.0 21706.6 29037.8 32692.0 34428.2 19979.3 25660.7 21775.7 21545.8 17406.5 24489.1 True False 22212.321546308904 25638.040876693027 28252.60596430182 28415.96116735441 18172.175842631903 25402.57665605143 20133.141417283347 20974.33539337822 29537.559179540247 27632.514529034215 0.8038472764745976 0.9278214926750318 1.022440644502912 1.0283523469243816 0.6576374301201549 0.919300218927245 0.7286033052159955 0.759045485033218 1.0689421387439912 1.0 14.754079231367045 -4.74322674736784 23.347234708477536 0.889119011829576 0.8038466523031392 0.038415523935375284 0.13433855028548913 2245.283346339488 2877925.978090858 0.034133633208062515 0.9754888185195162 1.8062308374360902e-05 4.74322674736784 -0.08527235952643675 VGS(ph)LDNVGHLPAGGAVK ddPTM_A459_Selumetinib_30min_R2 4 VGSLDNVGHLPAGGAVK 17 0 E7EVA0;P27816-4;H0Y2V1;H7C4C5;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VGS(1)LDNVGHLPAGGAVK;VGS(1)LDNVGHLPAGGAVK;VGS(1)LDNVGHLPAGGAVK;VGS(1)LDNVGHLPAGGAVK 110.38 0.001414 202671000.0 1133030.0 1086760.0 905870.0 798840.0 761320.0 615400.0 787200.0 723190.0 499952.0 755310.0 True False 1070060.7284784573 1170110.9975158372 847587.3104366827 690036.6139241375 665676.1753128455 700165.7639550101 823806.359807207 725294.3631694502 599956.3698260346 733502.2377689399 1.4588377149785008 1.595238483627412 1.1555347302207968 0.9407423432312766 0.9075312126348819 0.9545516399304685 1.1231136285458938 0.9888100210512578 0.8179339324865517 1.0 19.484441841716837 -5.432592408984357 3.241633903214333 0.9672698717377486 1.5273604222106607 0.8833779802441435 0.08101520407322563 0.07750696053878987 1.5376055290802686 0.023100627566242832 0.053196127999013985 3.6932405139169195e-06 5.432592408984357 0.5600905504729121 VGS(ph)LTPPSS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 VGSLTPPSSPK 11 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 2 VGS(0.985)LT(0.015)PPS(0.185)S(0.815)PK 147.33 0.012165 54234000.0 8635.5 9980.7 10129.0 11014.0 7060.4 8530.4 7250.7 7657.8 5893.6 8039.2 True False 8836.690348242038 8812.155004098453 8753.537434614373 9090.611658385902 6421.788066614866 8444.591920983497 6703.7738614279415 7454.6902679599625 10001.008748486964 9071.109628439262 0.974157595950303 0.9714528172464206 0.9649908107350776 1.0021499056615408 0.7079385355989543 0.9309326275264561 0.73902467680587 0.8218057738590671 1.1025121686471886 1.0 13.147063324669446 VGS(ph)PATVTFQQNK ddPTM_A459_Selumetinib_30min_R2 2 VGSPATVTFQQNK 13 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;J3QQK4 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 VGS(0.999)PAT(0.001)VTFQQNK;VGS(0.996)PAT(0.003)VT(0.001)FQQNK 155.14 0.00012184 0.0 37346.0 36940.0 34852.0 38966.0 34630.0 30970.0 32108.0 32103.0 27470.0 37875.0 True False 35270.45882788319 39773.17921917902 32609.66026398848 33658.76357990073 30279.469803872013 35235.83638233127 33601.085620795006 32196.41441506226 32964.76757592953 36781.450338931885 0.9589197408714096 1.0813379802231589 0.8865789674822118 0.9151015870702114 0.8232266407347795 0.9579784390675689 0.9135334607844277 0.8753437974408387 0.8962334892226224 1.0 15.166690747704171 -5.2754096660047445 24.975611154904517 0.9031847486864989 1.0201288624302558 0.4165455383256952 0.05254546123241402 575.6904795632006 1029200.1417705622 0.01290575590303262 0.02706966241744769 5.303839019155708e-06 5.2754096660047445 0.1169441137437569 VGS(ph)PLDYSLVDLPSTNGQS(ph)PGK ddPTM_A459_Selumetinib_30min_R1 1 VGSPLDYSLVDLPSTNGQSPGK 22 0 Q96T23-3;Q96T23-2;Q96T23 Q96T23-3 RSF1 Remodeling and spacing factor 1 2 VGS(0.801)PLDY(0.003)S(0.196)LVDLPS(0.095)T(0.261)NGQS(0.644)PGK 76.762 0.0082633 0.0 492.5 586.99 380.24 391.89 323.82 366.55 436.19 361.07 314.1 344.11 True False 503.97429176182095 518.2649379157526 328.6054965088132 323.4537681863857 294.53053817506435 362.86283980077144 403.2878371214161 351.49325067934706 533.0047590436668 388.2798704152448 1.297966570409244 1.334771584634289 0.8463109255635297 0.8330428457196841 0.7585521697534294 0.934539406878623 1.0386524459537938 0.9052574636522971 1.3727334318764617 1.0 8.600953105352636 -5.253354336114779 24.62679182053482 0.9477610846589964 1.3163691438239207 0.44159481572615866 0.15921770080242847 442.79762721971366 1348737.9041062342 0.0417676556928837 0.10634088225589068 5.580147308462219e-06 5.253354336114779 0.36860805916492423 VGS(ph)PLTLTDAQTR ddPTM_A459_Selumetinib_30min_R1 4 VGSPLTLTDAQTR 13 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VGS(0.989)PLT(0.005)LT(0.005)DAQTR;VGS(0.997)PLT(0.003)LTDAQTR;VGS(0.999)PLT(0.001)LTDAQTR;VGS(1)PLTLTDAQTR 219.84 1.3254e-08 215977000.0 8073.900000000001 8368.7 10864.5 9366.300000000001 7414.0 7617.599999999999 7110.799999999999 7457.099999999999 4870.370000000001 7631.300000000001 True False 8262.006160925412 7388.888713496924 9389.16057442668 7730.651532226242 6743.4050090480105 7540.973860227411 6574.426631062073 7259.313483925435 8264.662172249304 8610.851690156796 0.9594876857964985 0.858090346851901 1.090386980553803 0.8977801279591512 0.7831286905982257 0.8757523798543203 0.7635048038949975 0.8430424474995515 0.9597961351136465 1.0 13.07194022476939 -5.991815692991063 24.981173238309346 0.8563128014913131 0.9641793833027359 0.19819919568728261 0.0854887727391471 265.71879283516176 811050.8540257355 0.023414892080487172 0.03466531206001586 1.019023752223917e-06 5.991815692991063 0.10786658181142283 VGS(ph)PLTLTDAQTR ddPTM_A459_Selumetinib_30min_R2 4 VGSPLTLTDAQTR 13 0 Q99569-2;Q99569;A0A0D9SF60 Q99569-2 PKP4 Plakophilin-4 1 VGS(0.998)PLT(0.002)LTDAQTR;VGS(0.994)PLT(0.006)LTDAQTR;VGS(0.995)PLT(0.005)LTDAQTR;VGS(0.984)PLT(0.011)LT(0.004)DAQTR 176.43 0.0001012 160061000.0 333105.0 265978.0 292832.0 277920.0 255020.0 166633.0 297452.0 232528.0 159758.0 207580.0 True False 314592.35762496735 286377.6573459334 273991.5079313749 240066.81656125822 222982.10769227368 189585.1832062318 311284.1073899563 233204.61798291738 191714.0640114797 201586.62604238832 1.5605814919429075 1.4206183364848606 1.3591750271853935 1.1908866241492555 1.106135422125605 0.9404650840595301 1.5441704318445288 1.156845682480348 0.9510257092708487 1.0 17.621040403044766 -1.5228787452815131 0.37854714273172796 1.0967810363200794 8.065303872190357 0.47190469785864286 0.16205582894134188 66.26555252610943 0.9062679409091322 0.13091272984863372 338.3080465019196 0.029999999999918796 1.5228787452815131 6.968522835870278 VGS(ph)PQPSSSGGEK ddPTM_A459_Selumetinib_30min_R2 2 VGSPQPSSSGGEK 13 0 V9GYB6;O94761 V9GYB6 RECQL4 ATP-dependent DNA helicase Q4 1 VGS(0.99)PQPS(0.008)S(0.002)SGGEK;VGS(1)PQPSSSGGEK 176.43 0.0001012 26375000.0 84373.0 74318.0 82939.0 77792.0 81374.0 57326.0 75159.0 74626.0 50022.0 62635.0 True False 79683.88643187983 80017.95162996612 77602.79503715549 67196.59540131489 71151.07062720986 65222.13614638427 78654.04242473308 74843.14930500065 60027.79773145792 60826.56480472602 1.310017862881 1.3155099566587558 1.2758043346075334 1.1047244837356645 1.1697367894377897 1.0722640076053864 1.293087036515038 1.230435247252128 0.9868681212586571 1.0 15.892413909501146 -1.5228787452805579 0.10406408625925817 0.9218902409982599 2.086085701737871 0.5043317475237282 0.08526831189840108 114.90734670825458 0.8455775622436857 1.020557801118933 19.130387862130092 0.029999999999984782 1.5228787452805579 1.1641954607396112 VGS(ph)PSGDAASSTPPSTR ddPTM_A459_Selumetinib_30min_R1 3 VGSPSGDAASSTPPSTR 17 0 F8WEJ1;C9JF34;C9J222;F8WB78;F8WDE4;Q9H980;Q6PIY2;Q9NP87-2;Q9NP87;Q9NP87-3 F8WEJ1 POLM DNA-directed DNA/RNA polymerase mu 1 VGS(0.496)PS(0.496)GDAAS(0.007)S(0.001)TPPSTR;VGS(0.936)PS(0.062)GDAAS(0.001)STPPSTR;VGS(0.678)PS(0.322)GDAASSTPPSTR 171.15 7.5137e-07 24845200.0 4317.0 3985.3 4648.9 4511.25 3929.0899999999997 3530.0700000000006 3921.65 3887.7200000000003 2511.11 3910.61 True False 4417.577700580265 3518.6992232842954 4017.6049145797983 3723.4448741504807 3573.7045032371807 3494.560700847111 3625.836783161472 3784.6050365056954 4261.170265782054 4412.574886067129 1.0011337630844368 0.7974253840755701 0.9104899108376691 0.8438258772462758 0.8098909583430044 0.7919549902442036 0.8217054388380326 0.8576863020400465 0.9656879205012155 1.0 12.107405047315801 -8.319989408810809 3.2899607683185934 0.9972266650240702 0.8484540763974818 0.43190104938189733 0.059365434125656695 0.21865240223631852 4.430140657627155 0.05445187813355573 0.014981006151962071 4.7864176487175985e-09 8.319989408810809 -0.14877258862658838 VGS(ph)PSGDAASSTPPSTR ddPTM_A459_Selumetinib_30min_R2 2 VGSPSGDAASSTPPSTR 17 0 F8WEJ1;C9JF34;C9J222;F8WB78;F8WDE4;Q9H980;Q6PIY2;Q9NP87-2;Q9NP87;Q9NP87-3 F8WEJ1 POLM DNA-directed DNA/RNA polymerase mu 1 VGS(0.976)PS(0.024)GDAASSTPPSTR;VGS(0.822)PS(0.177)GDAASS(0.001)TPPSTR 159.54 9.6588e-05 2933100.0 19692.6 16550.7 15271.900000000001 20408.3 18567.9 12877.3 15542.1 12415.2 10784.4 15849.7 True False 18598.164127723765 17820.085471111695 14289.322580787495 17628.654333718823 16235.234402867878 14651.031186509346 16264.838446086891 12451.326176552997 12941.581341312505 15392.077978533822 1.2082945625445265 1.1577439703699548 0.928355651570616 1.1453069792333554 1.0547785962044853 0.9518553119950433 1.0567019260667885 0.8089438082316065 0.8407949439550111 1.0 13.909900392694098 VGS(ph)TENIK ddPTM_A459_Selumetinib_30min_R1 1 VGSTENIK 8 0 E7EVA0;H0Y2V1;H7C4C5;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VGS(0.5)T(0.5)ENIK 150.15 0.0013247 66221000.0 4474.9 5287.3 4895.5 5469.8 3341.4 4373.7 3632.8 3812.2 3101.3 5271.0 True False 4579.156463360346 4668.260458000916 4230.717989056638 4514.602110862465 3039.170959972085 4329.704549001865 3358.77497121594 3711.0880722292272 5262.679590009948 5947.584193887866 0.769918729030552 0.7849002730887494 0.7113338544083841 0.7590648511545195 0.5109925073604406 0.7279770084551908 0.5647292853235505 0.6239656222173348 0.8848432268379199 1.0 12.5380880742204 -8.44520983967661 3.880018153049683 0.997348303382917 0.6812997798865223 0.6066159089828497 0.0862401039445848 0.14299018016212528 3.9807922468857764 0.08711231677352872 0.02291423563938951 3.587485548914258e-09 8.44520983967661 -0.3160485234963947 VGS(ph)TENIK ddPTM_A459_Selumetinib_30min_R2 1 VGSTENIK 8 0 E7EVA0;H0Y2V1;H7C4C5;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VGS(0.5)T(0.5)ENIK 105.98 0.013925 69217000.0 126240.0 94306.0 95279.0 93134.0 67734.0 70343.0 95120.0 99966.0 59645.0 66464.0 True False 119224.08617876007 101538.96695841647 89148.8528719313 80448.98853488875 59224.6493703571 80032.10973982325 99543.26847670415 100256.88450973784 71575.66662054308 64545.011625789215 1.8471464048993 1.573149719874652 1.381188888597419 1.2464013330930293 0.9175712867436167 1.2399426032149958 1.5422302354490744 1.5532863343645258 1.1089263882314453 1.0 15.97801798041378 -5.020176278629405 1.6360449769592065 1.2563578012244188 1.913828012311836 0.5075618426656419 0.1941986182220322 0.5976360705643353 2.1869965795810367 0.06027075771742246 0.5424022278219283 9.546050364887841e-06 5.020176278629405 0.6574702110874173 VGSGQGGS(ph)PCWK ddPTM_A459_Selumetinib_30min_R2 2 VGSGQGGSPCWK 12 0 Q9UMN6;A0A669KBI7;Q9UMN6-2 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 VGS(0.01)GQGGS(0.99)PCWK;VGS(0.005)GQGGS(0.995)PCWK 123.72 0.003228 54134000.0 64115.0 57664.0 65387.0 72710.0 80748.0 49852.0 56214.0 62216.0 45291.0 57871.0 True False 60551.74497268063 62086.64338101618 61180.07160798274 62806.77256825388 70603.71434372097 56718.66048860116 58828.062385927784 62397.03825958672 54350.46553627326 56200.1138630845 1.0774310016559332 1.1047423059012393 1.0886111682447919 1.1175559665459862 1.2562913042440933 1.0092267895894296 1.0467605551342036 1.1102653352553564 0.9670881747443185 1.0 15.77828543294122 -8.259063938798834 24.92156341268007 0.9835440774392886 1.1018613813798606 0.37441062998404884 0.06091397487450603 210.01968493520795 2203454.707253217 0.04782740816406516 0.016067609018169615 5.5072660997300394e-09 8.259063938798834 0.11831730394057194 VGSPQPS(ph)SSGGEK ddPTM_A459_Selumetinib_30min_R2 1 VGSPQPSSSGGEK 13 0 V9GYB6;O94761 V9GYB6 RECQL4 ATP-dependent DNA helicase Q4 1 VGS(0.043)PQPS(0.447)S(0.447)S(0.064)GGEK 96.707 0.017636000000000002 0.0 30520.0 24308.0 32634.0 33903.0 41795.0 27526.0 27634.0 33735.0 31393.0 29359.0 True False 28823.820581240132 26172.345437460837 30534.363969212667 29285.352914062867 36544.33844795928 31317.45664385049 28919.035755732195 33833.16326487012 37672.477193707935 28511.329386157107 1.010960246393658 0.9179629993039925 1.0709554632004563 1.027147928369891 1.2817479659753213 1.0984214807975885 1.0142998021612082 1.18665681303857 1.321316052418053 1.0 14.799247688348396 -5.786853987371427 1.9347561240727518 1.148638570437266 0.9732848525627346 0.3049958232146158 0.10331734513576496 0.40570745402542024 3.100858069198963 0.03231626829288186 0.0630549013714127 1.6336010828834279e-06 5.786853987371427 -0.17535371787453136 VGSPS(ph)GDAASSTPPSTR ddPTM_A459_Selumetinib_30min_R2 1 VGSPSGDAASSTPPSTR 17 0 F8WEJ1;C9JF34;C9J222;F8WB78;F8WDE4;Q9H980;Q6PIY2;Q9NP87-2;Q9NP87;Q9NP87-3 F8WEJ1 POLM DNA-directed DNA/RNA polymerase mu 1 VGS(0.434)PS(0.564)GDAAS(0.002)STPPSTR 118.31 0.0015986 0.0 12719.0 9749.4 10634.0 12579.0 9688.3 7271.6 10224.0 8970.5 7318.7 8744.5 True False 12012.128898191131 10497.147630738065 9949.82001742378 10865.718500014656 8471.169139499076 8273.196894987412 10699.436258471667 8996.60266985378 8782.644501563725 8492.023564060457 1.4145190257158846 1.2361185236418326 1.1716665577251741 1.2795205310074786 0.9975442337854972 0.9742315047264879 1.2599395394701116 1.0594180058483091 1.034222813362556 1.0 13.051892659167978 -1.5228787484768873 0.3896043519985794 1.0506333894496387 6.407838883583103 0.5873374922148666 0.09184913437811373 53.91238935264632 0.7264464373502756 0.07094250013952565 219.82844657090803 0.029999999779190167 1.5228787484768873 5.3572054941334635 VGST(ph)ENIK ddPTM_A459_Selumetinib_30min_R2 1 VGSTENIK 8 0 E7EVA0;H0Y2V1;H7C4C5;F8W9U4;P27816;P27816-6;P27816-2;P27816-5 E7EVA0;P27816 MAP4 Microtubule-associated protein;Microtubule-associated protein 4 1 VGS(0.393)T(0.607)ENIK 115.57 0.022862 79862000.0 181980.0 155590.0 140560.0 136900.0 134640.0 108500.0 141740.0 136860.0 70461.0 110610.0 True False 171866.28012365918 167523.2526992976 131516.5226301564 118253.98383432785 117725.31950312821 123444.89013506439 148331.19085248158 137258.23994160732 84555.16884483323 107416.40190070645 1.6000003452222211 1.559568648130224 1.224361645921892 1.1008931759196277 1.095971540844862 1.1492182567162728 1.3808988965167157 1.277814537750818 0.7871718596848395 1.0 16.71285477627147 -5.300033621973814 3.062544027768408 1.1373419138522975 1.5990646951342786 0.5991863216588331 0.14971390735299742 0.18139800828379665 3.388382914481388 0.041358108062372216 0.11328454311368373 5.011484344886999e-06 5.300033621973814 0.4617227812819811 VGT(ph)PSQGPFLR ddPTM_A459_Selumetinib_30min_R1 1 VGTPSQGPFLR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 VGT(0.983)PS(0.017)QGPFLR 112.02 0.0185 7185300.0 2901.9 4236.2 3952.3 3744.0 2472.9 2930.2 2833.6 2797.8 2490.9 4071.3 True False 2969.5086238855383 3740.2237346440493 3415.5993684298937 3090.1806835842394 2249.226631625956 2900.72484840873 2619.859270655553 2723.593255464804 4226.875371862049 4593.891012820277 0.6464038035727149 0.8141733715941717 0.7435090120549013 0.6726717449239439 0.48961253659457477 0.6314309243109187 0.5702919950308467 0.5928728495874216 0.9201078911245415 1.0 12.165500914749964 -8.364097582497912 4.354960585638463 0.9919221953156915 0.6470602580767214 0.6873739570275441 0.08545784368461373 0.14159456075119692 4.260362746623297 0.09204891708692636 0.02427105895718237 4.324166595523468e-09 8.364097582497912 -0.3448619372389701 VGT(ph)PSQGPFLR ddPTM_A459_Selumetinib_30min_R2 1 VGTPSQGPFLR 11 0 H3BLZ3;Q8IX03-2;H0YBE8;Q8IX03;H0YAU4 H3BLZ3 WWC1 Protein KIBRA 1 VGT(0.998)PS(0.002)QGPFLR 107.53 0.02454 2771900.0 12401.0 18714.0 13080.0 12640.0 12616.0 9458.6 15278.0 14997.0 9038.4 10073.0 True False 11711.802065136277 20149.303625005843 12238.44704042721 10918.410194783793 11031.065291528997 10761.436293378056 15988.45727278268 15040.638787112992 10846.332553996415 9782.166317202922 1.1972605745355092 2.0597997387931617 1.2510978288014458 1.1161546267704192 1.1276710018853147 1.1001076800803304 1.6344495436215771 1.5375570501865745 1.1087863569567458 1.0 13.255938278367035 -5.406171453597733 20.748631826425644 1.255022235767802 1.635343998107141 0.24824178370053995 0.272364064569296 7.613503928652559 1333.8843466743183 0.07078131721918439 0.14734321543334294 3.924899550745686e-06 5.406171453597733 0.3803217623393389 VGT(ph)TPVSSPSQTPR ddPTM_A459_Selumetinib_30min_R1 1 VGTTPVSSPSQTPR 14 0 H7C3Y7;H0Y764;A0A494C1V1;Q6ZNJ1-2;Q6ZNJ1-3;Q6ZNJ1;H7C354 H7C3Y7 NBEAL2 Neurobeachin-like protein 2 1 VGT(0.438)T(0.332)PVS(0.006)S(0.01)PS(0.166)QT(0.048)PR 93.478 0.033642 3551300.0 1412.0 1733.7 1358.8 1915.0 1654.7 1793.8 1689.2 1508.2 931.79 1492.2 True False 1444.8968527262764 1530.717598024736 1174.2824233541326 1580.5811990020873 1505.032677161013 1775.7560006400856 1561.7822840172787 1468.197636675966 1581.179574751031 1683.7384052588652 0.8581480639827371 0.909118419609486 0.6974256925461015 0.9387332343702655 0.893863721621069 1.0546507670632324 0.9275682488083198 0.8719867837487729 0.9390886195934538 1.0 10.71745229554157 -5.943927120547208 24.99999813507415 0.9431041502854586 0.8282790602144173 0.4046843528950407 0.06925989971963402 92.30978215239648 41155.3193084959 0.019580816144329036 0.029043049891078834 1.1378182083759796e-06 5.943927120547208 -0.11482509007104125 VGTEGLVDS(ph)FSQGLER ddPTM_A459_Selumetinib_30min_R1 2 VGTEGLVDSFSQGLER 16 0 T1ECW5;O75170-6;O75170-2;O75170-4;O75170-3;O75170-5;O75170 T1ECW5 PPP6R2 Serine/threonine-protein phosphatase 6 regulatory subunit 2 1 VGTEGLVDS(0.997)FS(0.003)QGLER;VGTEGLVDS(0.999)FS(0.001)QGLER 150.92 0.00038723 2864000.0 2075.35 2461.1 2268.5 2200.1 2109.8 1975.17 2477.8999999999996 1904.25 1431.65 1836.1399999999999 True False 2123.7016170718666 2172.9532678656515 1960.4501599785465 1815.8938359919016 1918.9689625154435 1955.301583110871 2290.990008031266 1853.7431041242598 2429.4054864210952 2071.8264545181696 1.0250383725145364 1.048810465339386 0.9462424594990871 0.8764700499078295 0.9262208995983329 0.9437574169626104 1.1057827758860554 0.8947386013349135 1.1725912086522157 1.0 11.016687446136407 -7.227545952367181 24.48206006776931 1.0345064074513688 0.9589710296924538 0.1949084224259181 0.08098267888445218 899.5710336341342 649783.1567935371 0.03095481909405697 0.02397594253734559 5.9218042540292414e-08 7.227545952367181 -0.07553537775891495 VGTGEPCCDWVGDEGAGHFVK ddPTM_A459_Selumetinib_30min_R1 2 VGTGEPCCDWVGDEGAGHFVK 21 0 P52209-2;P52209;K7EM49;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 ; 218.11 3.1074e-20 40315000.0 6684.1 8318.4 7828.900000000001 8927.8 7950.799999999999 7142.900000000001 7640.4 6958.3 3831.1 6009.9 False True 6839.826525005457 7344.477860880752 6765.778381069448 7368.727325561798 7231.651543827748 7071.048911234292 7064.078476678666 6773.743280256185 6501.096887526879 6781.3292063833605 1.008626231943884 1.0830439929044133 0.9977068175219581 1.0866199090622988 1.0664062049989393 1.0427231440966196 1.0416952579192218 0.9988813511486753 0.9586759010913827 1.0 12.72735236798054 -7.825259347681244 2.9584480202680385 0.9787105561503183 1.0490878779403514 0.49795522512020873 0.028407805275151986 0.2008025688321203 3.4952337060259393 0.017223050994783072 0.007471040980107428 1.495342415625773e-08 7.825259347681244 0.07037732179003309 VGVAAPPFLGS(ph)PVPFGGFR ddPTM_A459_Selumetinib_30min_R1 2 VGVAAPPFLGSPVPFGGFR 19 0 Q9BRQ0;Q5T171 Q9BRQ0 PYGO2 Pygopus homolog 2 1 VGVAAPPFLGS(1)PVPFGGFR;VGVAAPPFLGS(1)PVPFGGFR 133.32 0.00022923 22334600.0 6273.1 7975.0 8591.0 9239.5 8293.400000000001 6923.6 7114.1 6992.7 3615.4 6329.200000000001 True False 6419.251024672238 7041.283292523087 7424.389386985097 7625.994771895457 7543.26343431869 6853.954870125827 6577.477709405232 6807.230880509234 6135.069741631564 7141.614471628742 0.8988515202233033 0.9859511907980699 1.0395953767148487 1.0678250418292667 1.056240639183978 0.9597206482307761 0.9210071105819788 0.9531781514603033 0.8590592177726977 1.0 12.802034539157077 -6.960093822961077 6.340459548871149 0.930765215059847 1.0131669284615548 0.3046318695085748 0.05467682767082371 0.23077191430059502 24.610111697796214 0.020431659874088678 0.017824976183271196 1.0962413436757822e-07 6.960093822961077 0.08240171340170777 VGVEASEETPQT(ph)SSSSARPGTPSDHQSQEASQFER ddPTM_A459_Selumetinib_30min_R1 1 VGVEASEETPQTSSSSARPGTPSDHQSQEASQFER 35 1 Q6Y7W6;I1E4Y6;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 VGVEASEET(0.003)PQT(0.372)S(0.153)S(0.153)S(0.153)S(0.153)ARPGT(0.014)PS(0.001)DHQSQEASQFER 81.368 1.1415e-06 16133000.0 1620.1 2115.8 2213.5 1968.6 1966.3 1898.7 2268.9 1963.4 479.71 1503.7 True False 1657.8451778341637 1868.0811523912662 1912.9188578851717 1624.8209651986992 1788.44851217846 1879.6008018816663 2097.7550462981303 1911.3242539779817 814.032833367837 1696.7145422783515 0.9770913942942966 1.1009990813674546 1.1274252740926596 0.9576277710314703 1.0540656472342884 1.107788467091073 1.2363629791734212 1.126485455480008 0.47977005741622997 1.0 10.728528148846864 -8.235275809596867 24.99788690151437 0.7398849600979739 1.088260271018519 0.5002932200248331 0.13834210742963496 491.5485511305818 469649.792461956 0.08852084396033552 0.033434677571695874 5.817336558934681e-09 8.235275809596867 0.3483753109205451 VGVEASEETPQT(ph)SSSSARPGTPSDHQSQEASQFER ddPTM_A459_Selumetinib_30min_R2 1 VGVEASEETPQTSSSSARPGTPSDHQSQEASQFER 35 1 Q6Y7W6;I1E4Y6;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 VGVEASEET(0.004)PQT(0.164)S(0.164)S(0.164)S(0.164)S(0.164)ARPGT(0.164)PS(0.013)DHQSQEASQFER 63.657 7.775100000000001e-05 21668000.0 2346.8 2011.3 12888.0 17383.0 18861.0 12702.0 3986.1 7216.3 11687.0 19919.0 True False 2216.374250984744 2165.5602426511846 12058.800111393415 15015.40541265242 16491.51256052065 14451.58520272431 4171.461548307307 7237.2982382772225 14024.726562063666 19343.886714222685 0.11457750366968103 0.11195062681270493 0.6233907533446794 0.7762351814029325 0.8525438968992299 0.7470879775210177 0.21564753815685964 0.37413878323408317 0.7250211278249432 1.0 14.23959008025679 -5.265526509751079 6.942693461712401 0.640216641690942 0.11084055847264598 0.5097798385897558 0.21513308428346983 0.11056547433824612 36.42840471188859 0.06034555638004887 0.14058877149926205 5.425921299749162e-06 5.265526509751079 -0.529376083218296 VGVEASEETPQTSSS(ph)SARPGTPSDHQSQEASQFER ddPTM_A459_Selumetinib_30min_R1 1 VGVEASEETPQTSSSSARPGTPSDHQSQEASQFER 35 1 Q6Y7W6;I1E4Y6;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 VGVEASEET(0.001)PQT(0.032)S(0.116)S(0.116)S(0.306)S(0.306)ARPGT(0.116)PS(0.007)DHQSQEASQFER 82.234 6.0419e-07 18217000.0 885.33 1107.5 889.91 1211.2 1230.8 1030.0 1150.7 1117.5 314.51 570.41 True False 905.9564664477009 977.8333851372189 769.0651099257256 999.6866570398581 1119.4743573153896 1019.6391351651736 1063.9017725661156 1087.8602698484233 533.7004990984516 643.6276797639118 1.4075784726660816 1.5192531581238031 1.1948912921330936 1.553206439795367 1.739319784577976 1.58420647095101 1.6529770331760187 1.6902011893700093 0.8292068782595203 1.0 9.330082561515745 -8.26491107741866 24.999941522470657 0.914603356001067 1.542291861658042 0.7339794527779224 0.1512531664605589 169.5029118177794 1220573.6101696468 0.13794218589613697 0.04120184029091654 5.433615743694132e-09 8.26491107741866 0.6276885056569751 VGVEASEETPQTSSSSARPGT(ph)PSDHQSQEASQFER ddPTM_A459_Selumetinib_30min_R2 1 VGVEASEETPQTSSSSARPGTPSDHQSQEASQFER 35 1 Q6Y7W6;I1E4Y6;Q6Y7W6-5;Q6Y7W6-4;E7ESB6;C9JHW1 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 VGVEASEETPQT(0.014)S(0.046)S(0.165)S(0.165)S(0.165)ARPGT(0.412)PS(0.033)DHQSQEASQFER 86.191 6.238e-09 22215000.0 13435.0 11219.0 22154.0 41286.0 44690.0 27375.0 14704.0 20963.0 25211.0 33485.0 True False 12688.336484566235 12079.461225229283 20728.635759451412 35662.77557767749 39075.64266633091 31145.657764492033 15387.765135423257 21023.99885938852 30253.904454195843 32518.20104552166 0.390191833392138 0.3714676961471349 0.6374471862829607 1.0967019832294471 1.2016545014784061 0.9577915371422845 0.47320468662710446 0.6465301948886224 0.9303683316258465 1.0 14.98895982716865 -5.493816201511699 4.11537724838478 0.8837713828406994 0.3938946616909463 0.5233056780178909 0.19902195487717503 0.19712296539897856 7.453184005149629 0.06234016483711902 0.12892538694904696 3.2076265422413073e-06 5.493816201511699 -0.48987672114975317 VGVNGFGR ddPTM_A459_Selumetinib_30min_R1 2 VGVNGFGR 8 0 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 143.02 0.030168 40382000.0 3894.7999999999997 4051.0 4683.3 4420.2 4178.6 4022.3 4314.8 3937.7 2969.1099999999997 3427.2 False True 3985.5412620384564 3576.7070367411916 4047.33358352547 3648.2950474303007 3800.6463677917504 3981.839313956192 3989.331162134593 3833.2594045477717 5038.362814785552 3867.1145037549795 1.0306240630238603 0.924903318292799 1.0466029851444785 0.9434153149299809 0.9828119555553143 1.029666773530966 1.0316040960930795 0.9912453848536591 1.3028739671125038 1.0 11.917041767353762 -8.200016038907508 24.999857122977186 1.1514379014520872 0.9967207748689383 0.38672991818198954 0.07747834817730369 183.46531883533413 74672.00801001042 0.04747105279659634 0.017942366284236462 6.309340430567456e-09 8.200016038907508 -0.15471712658314896 VGVSSKPDSS(ph)PVLSPGNK ddPTM_A459_Selumetinib_30min_R1 2 VGVSSKPDSSPVLSPGNK 18 1 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 VGVSSKPDS(0.165)S(0.82)PVLS(0.015)PGNK;VGVSSKPDS(0.05)S(0.926)PVLS(0.023)PGNK 108.28 0.00084174 466750000.0 20473.1 20664.4 25942.0 25476.0 22711.8 19536.9 20663.1 21725.2 11159.6 17516.1 True False 20950.083396282087 18245.002441381075 22419.21888920585 21027.094843747884 20657.521700093963 19340.376524085903 19104.46573104276 21148.977122604883 18937.026135064345 19764.46205626243 1.0599875340216502 0.9231216306036567 1.1343197110746688 1.06388399461069 1.04518512273642 0.97854302682414 0.9666069168317917 1.07005073360465 0.9581351660954562 1.0 14.27062106836121 -6.746860740197941 24.00860802342826 0.9972915772098387 1.0444899838228052 0.16804253011758585 0.056164005555490504 307.421208831411 506270.0192519746 0.018715455995449975 0.01862357840895417 1.7911801173772283e-07 6.746860740197941 0.04719840661296648 VGVSSKPDSS(ph)PVLSPGNK ddPTM_A459_Selumetinib_30min_R2 2 VGVSSKPDSSPVLSPGNK 18 1 Q8N4C8;Q8N4C8-2;Q8N4C8-3;Q8N4C8-4;Q8N4C8-5 Q8N4C8;Q8N4C8-4 MINK1 Misshapen-like kinase 1 1 VGVSS(0.001)KPDS(0.233)S(0.765)PVLS(0.001)PGNK;VGVSSKPDS(0.132)S(0.625)PVLS(0.243)PGNK 106.54 0.0039238 169157600.0 336500.0 287473.0 307790.0 315120.0 280645.0 227320.0 293160.0 274000.0 221850.0 281820.0 True False 317798.67711622885 309521.2547286157 287987.1264964135 272200.11238767987 245387.86610186708 258631.2665944958 306792.5208855195 274797.2946368582 266226.1990069151 273683.12434370344 1.1611920825528252 1.1309475345652118 1.0522648306760283 0.9945812809628659 0.8966130691847046 0.9450026091842446 1.1209771213377255 1.004071022997222 0.9727534339040078 1.0 18.062146953435438 -5.380856620051258 2.17630414316551 0.9906381787009771 1.1561360777074299 0.5727275402204284 0.053603486800728746 0.2630967105073633 2.357384075781898 0.016781386375560203 0.05053332189313611 4.1604794377679904e-06 5.380856620051258 0.16549789900645273 VHAPGLNLS(ph)GVGGK ddPTM_A459_Selumetinib_30min_R1 1 VHAPGLNLSGVGGK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VHAPGLNLS(1)GVGGK 133.23 0.0004917 11198000.0 5043.0 5917.8 6534.2 7398.2 6040.3 5605.8 5195.7 5409.1 3615.4 4815.7 True False 5160.492088030177 5224.941224889417 5646.891529791413 6106.243251413703 5493.955931501582 5549.410741659156 4803.78416591793 5265.633096766989 6135.069741631564 5433.842003890307 0.9496949091150557 0.9615556030426852 1.0392078985271518 1.12374324594679 1.011062877346864 1.0212683286864264 0.8840492900748139 0.9690442035298615 1.1290482382887137 1.0 12.407756902574251 -5.18651990643017 6.153497519673842 1.019268846791221 0.9539348126713604 0.1361285296142173 0.066831631541719 0.5295103872912198 34.43567106129262 0.018289430780997123 0.04976843732469838 6.508487776898227e-06 5.18651990643017 -0.0653340341198606 VHAYFAPVT(ph)PPPSVGGSR ddPTM_A459_Selumetinib_30min_R2 1 VHAYFAPVTPPPSVGGSR 18 0 J3KTA1;Q96IG2-2;Q96IG2 J3KTA1 FBXL20 F-box/LRR-repeat protein 20 1 VHAYFAPVT(1)PPPSVGGSR 98.804 0.0043156 10348000.0 22034.0 9316.1 22142.0 30471.0 14491.0 15561.0 26538.0 24590.0 14203.0 16690.0 True False 20809.438489090615 10030.614914017156 20717.40782638679 26320.797234593098 12670.51102881632 17704.386501306315 27772.0695840494 24661.552828906366 17043.996864977336 16208.116334172213 1.2838900005435705 0.6188637042830951 1.2782119401936582 1.6239269691753087 0.7817386528811235 1.0923161048628123 1.7134668218969065 1.5215557638188615 1.051571725768207 1.0 13.984428813819093 VHDRS(ph)EEEEEEEEEEEEEQPR ddPTM_A459_Selumetinib_30min_R1 1 VHDRSEEEEEEEEEEEEEQPR 21 1 Q5TAQ8;V9GY54;Q5TAQ9-2;Q5TAQ9;V9GYQ9 Q5TAQ8 DCAF8 DDB1- and CUL4-associated factor 8 1 VHDRS(1)EEEEEEEEEEEEEQPR 117.84 4.1582e-05 16047000.0 284.98 303.05 331.21 341.86 286.93 251.48 216.27 210.9 0.0 184.09 True False 291.61947952544915 267.5687651158772 286.2335012063013 282.1605685069734 260.97723216160585 248.95033952557085 199.95657978002404 205.30624690025275 0.0 207.7197446884495 1.4039083283239997 1.2881238878720598 1.3779792654550553 1.3583714390279782 1.2563910693855085 1.1984914573189056 0.9626267357488373 0.9883809900122077 0.0 1.0 7.6984945470753745 -7.640080097820237 1.4536238938153339 0.546358297054753 1.3274033978097037 0.5913261826132356 0.2520500461867113 0.2731755735537963 1.0934075561381928 0.17762154794476057 0.07594674611147892 2.2904451823172346e-08 7.640080097820237 0.7810451007549507 VHDRS(ph)EEEEEEEEEEEEEQPR ddPTM_A459_Selumetinib_30min_R2 2 VHDRSEEEEEEEEEEEEEQPR 21 1 Q5TAQ8;V9GY54;Q5TAQ9-2;Q5TAQ9;V9GYQ9 Q5TAQ8 DCAF8 DDB1- and CUL4-associated factor 8 1 VHDRS(1)EEEEEEEEEEEEEQPR;VHDRS(1)EEEEEEEEEEEEEQPR 133.35 2.3934e-05 141573000.0 24785.0 27295.0 25248.0 33870.0 27533.0 21387.0 23985.0 26460.0 20621.0 23543.0 True False 23407.54892221615 29388.43873274203 23623.571167943897 29256.84757099105 24074.05839185698 24332.865118143953 25100.350025375858 26536.994219311193 24745.77619888037 22863.25241793989 1.0238066087154412 1.2854006156045448 1.0332550564593959 1.2796450407044606 1.0529586058791451 1.0642783744560733 1.0978468665149586 1.160683254255141 1.0823384069128912 1.0 14.480743028660394 VHDYDMR ddPTM_A459_Selumetinib_30min_R1 2 VHDYDMR 7 0 J3QR07;Q96MU7;Q96MU7-2 J3QR07 YTHDC1 YTH domain-containing protein 1 0 ; 147.69 0.0040935 4429900.0 1362.27 1332.3000000000002 1300.08 1462.37 1581.3 1081.77 1242.64 1329.66 777.04 927.65 False True 1394.008240484012 1176.3136966305342 1123.5362768282612 1206.994531584691 1438.27169420119 1070.8883759685723 1148.906664344797 1294.39309745562 1318.580127243843 1046.722913576187 1.3317834380077775 1.123806196820124 1.073384619994261 1.1531175212940807 1.3740710894416697 1.0230867807315143 1.0976225412124527 1.2366148487504243 1.2597222341668635 1.0 10.03166387008693 VHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGS(ph)SPR ddPTM_A459_Selumetinib_30min_R1 1 VHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 40 2 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 VHEPPREDAAPTKPAPPAPPPPQNLQPES(0.01)DAPQQPGS(0.556)S(0.434)PR 56.655 3.6866e-05 28837000.0 1259.0 1214.3 1563.2 1538.0 1645.9 1313.5 1255.8 1038.6 824.22 996.07 True False 1288.3322504124515 1072.1291914872454 1350.9260260429646 1269.4171718356197 1497.0286356072472 1300.287382562579 1161.0739949496194 1011.0529541517427 1398.641141352981 1123.9252870434236 1.1462792636346084 0.9539150011541853 1.2019713780056367 1.1294497832457566 1.3319645468119168 1.156916209246515 1.0330526489033078 0.8995730995708792 1.2444253701526902 1.0 10.134330420225847 -10.713136419279278 5.257831828647102 0.9999934982021977 1.1176318990916303 0.07944912396944748 0.12374906830868289 9.776674993749873e-06 1.5055956628617122e-06 0.12420288343577733 0.030121959269064767 1.9358137964136398e-11 10.713136419279278 0.11763840088943256 VHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 VHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 40 2 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 VHEPPREDAAPTKPAPPAPPPPQNLQPES(0.001)DAPQQPGS(0.164)S(0.835)PR 60.496 1.764e-05 36805000.0 3430.2 3945.0 4515.1 5278.0 4432.4 3230.7 4420.5 4096.8 2264.9 3497.6 True False 3510.116985992684 3483.1175660192584 3901.9742196690077 4356.296380330561 4031.4902026037776 3198.2020912408993 4087.0581260350336 3988.13955571814 3843.3698782489696 3946.55102950905 0.8894138096142499 0.8825725399153289 0.988704869262621 1.1038236545676905 1.0215223805443343 0.810379003673685 1.0356025034201732 1.01053794209124 0.9738553611777533 1.0 11.94637668827541 -5.269604457836474 8.314708552081877 0.9934650574780585 0.8858200918770862 0.2722558548858697 0.0700173291978676 0.17985260527449343 123.58254608790598 0.019233103062867088 0.04348466253880922 5.375211313470751e-06 5.269604457836474 -0.10764496560097225 VHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 VHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR 40 2 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 VHEPPREDAAPTKPAPPAPPPPQNLQPES(0.004)DAPQQPGS(0.338)S(0.658)PR;VHEPPREDAAPTKPAPPAPPPPQNLQPES(0.001)DAPQQPGS(0.112)S(0.886)PR 73.817 1.0583e-08 33666000.0 61295.0 60463.0 64883.0 68863.0 67807.0 45929.0 52333.0 53651.0 42190.0 68722.0 True False 57888.46928332613 65100.317680812674 60708.49841926905 59483.740604699036 59288.47845772873 52255.30284804949 54766.58819587218 53807.11552759883 50629.178887093825 66737.81729880076 0.8674012969909694 0.9754636923371854 0.9096566366182305 0.8913048555120775 0.888379045905568 0.7829938850725418 0.8206230052545681 0.8062462589492826 0.7586280303476992 1.0 16.026216882616133 -6.598674570343935 4.988031908663204 0.8210053059879281 0.9127973563164724 0.22410384088923763 0.06642683432532086 0.2526730360974073 11.479095735829214 0.02100249036844928 0.021070498446057448 2.5195642042966966e-07 6.598674570343935 0.09179205032854432 VHFEESSK ddPTM_A459_Selumetinib_30min_R2 1 VHFEESSK 8 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 96.034 0.035685 0.0 34606.0 29181.0 30658.0 43859.0 41464.0 37573.0 45104.0 43934.0 46295.0 34119.0 False True 32682.737058794108 31419.08886829623 28685.497657906544 37885.32853900492 36254.92162713682 42748.33969626515 47201.42537188044 44061.84066633477 55555.29359037712 33133.895818191835 0.9863837696033914 0.9482461416760383 0.865744789423677 1.1434009676038264 1.0941943508867864 1.2901694364836689 1.424566118964042 1.3298116499220431 1.6766906582676897 1.0 15.016020222182089 -6.544647912364472 1.207329428090563 1.39085350872755 0.9449911403331325 0.5228738479817556 0.16519945608773465 0.32939769256584284 1.0080881944832158 0.07170336247311825 0.07945987137911069 2.85333055866131e-07 6.544647912364472 -0.4458623683944175 VHFTAER ddPTM_A459_Selumetinib_30min_R2 1 VHFTAER 7 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 99.375 0.031391 0.0 2244.4 2695.3 3313.2 2444.8 3815.9 3632.4 2624.9 2478.2 2970.8 4374.8 False True 2119.6652330450656 2902.0208432445374 3100.032319139406 2111.814022484763 3336.512527421169 4132.730128355828 2746.963051140676 2485.4111517119027 3565.0430110874213 4248.488156904531 0.49892224122132517 0.6830714211897354 0.7296789362826197 0.4970742401747545 0.7853411388234087 0.9727531243412846 0.6465742517550352 0.5850107285041334 0.8391321522913057 1.0 12.052733827895374 -6.294976681467779 23.064670097322935 0.784538704821453 0.6170707942150719 0.3348398356241963 0.13750267898131083 359.98367406754176 247570.76955709615 0.04373534482610282 0.04959623016653035 5.070179308093004e-07 6.294976681467779 -0.1674679106063811 VHGLPT(ph)TSPSGMNMAELAQQVVK ddPTM_A459_Selumetinib_30min_R2 1 VHGLPTTSPSGMNMAELAQQVVK 23 0 B1AKB5;B0QYS6;B0QYS7;P19484-2;P19484 B1AKB5 TFEB Transcription factor EB 1 VHGLPT(0.45)T(0.362)S(0.094)PS(0.094)GMNMAELAQQVVK 94.45 0.0015313 0.0 8106.8 10400.0 9513.7 9515.2 11572.0 6782.8 8061.6 6039.3 6679.0 7773.3 True False 7656.256510091663 11197.646558729333 8901.598899733359 8219.213345364456 10118.221905007418 7717.069131872016 8436.48037375735 6056.873363140063 8014.986626852332 7548.864631541094 1.014226229213577 1.4833550613615047 1.1791970493867638 1.0888012630432493 1.340363405475691 1.022282092545165 1.117582681044189 0.8023555407038154 1.0617472981782798 1.0 12.882043960408673 -7.105067289873599 1.7468327207037 0.9626373589930715 1.2251014302412715 0.34542590525955186 0.14556001342484026 0.3782188581070163 2.287533985985326 0.0691107629728491 0.048386168119088274 7.851139791076363e-08 7.105067289873599 0.26246407124820004 VHGPGIQSGTTNKPNK ddPTM_A459_Selumetinib_30min_R2 1 VHGPGIQSGTTNKPNK 16 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 116.98 0.0014956 5746100.0 108820.0 93994.0 127420.0 134490.0 161620.0 112500.0 101840.0 128110.0 113750.0 128690.0 False True 102772.22004097472 101203.03756165429 119221.93592440645 116172.2299918095 141315.85069886775 127995.8538266796 106575.76179213169 128482.77889024782 136503.1784405528 124974.38532322485 0.8223462733997208 0.8097902406153865 0.9539709726601922 0.9295683246718911 1.1307585177024757 1.024176702254948 0.8527808439824827 1.0280729011624992 1.0922492484160709 1.0 16.931272905692566 -5.447163618772913 1.7063062920283572 1.0117285110951941 0.80468351024661 0.5249079911708926 0.07254692125967925 0.3455148208657646 1.876469620544264 0.022870821609485965 0.07497884997250409 3.5713826233862063e-06 5.447163618772913 -0.20704500084858413 VHGS(ph)PLELK ddPTM_A459_Selumetinib_30min_R2 2 VHGSPLELK 9 0 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9;D6RD46 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 VHGS(1)PLELK;VHGS(1)PLELK 93.839 0.015899 8870600.0 109603.0 84082.0 99423.0 93759.0 97860.0 91621.0 103337.0 100039.0 81008.0 92259.0 True False 103511.70403557214 90530.81903375789 93026.23242357769 80988.86245670344 85565.95192049987 104240.96109737076 108142.37525838098 100330.09692765192 97211.86355263561 89595.24295233058 1.1553258925883583 1.0104422517379086 1.0382943263301667 0.9039415463139467 0.955027846355922 1.1634653544366467 1.207010235084897 1.1198149993413473 1.0850114397742912 1.0 16.451134514161872 -6.766577505850751 24.998449952441828 1.1282957156238125 1.0078763150464354 0.2890797278852286 0.07880784074482106 150.31227810832635 731307.0887829013 0.028257014669516495 0.02567265950259226 1.711679676555503e-07 6.766577505850751 -0.1204194005773771 VHHEPQLSDK ddPTM_A459_Selumetinib_30min_R1 1 VHHEPQLSDK 10 0 O43852-5;O43852;O43852-3;O43852-13;O43852-14;O43852-9;O43852-11;O43852-10;O43852-6;O43852-2;O43852-4;O43852-12;O43852-7;O43852-8 O43852-5 CALU Calumenin 0 93.556 0.035202 1612100.0 2770.5 2638.8 3504.3 3646.4 4412.6 2991.6 3178.7 3460.6 1734.3 2666.3 False True 2835.0472595454316 2329.848069255161 3028.435307742044 3009.6246914053336 4013.4811091078072 2961.5072201554717 2938.9280998139466 3368.813646386984 2942.980431739676 3008.5455769613386 0.9423314977361447 0.7744100960598813 1.0066110784337177 1.0003586830966626 1.3340270261624103 0.9843650841901567 0.9768600889145557 1.1197482505116376 0.9782070294285241 1.0 11.55485049722445 -5.480036589390316 3.3153955780697157 1.065083465032988 0.8589747063402473 0.3285662005975537 0.10995435411105235 0.2635935217109477 5.80471162428999 0.03028401494192046 0.06627773880900201 3.3110322479961183e-06 5.480036589390316 -0.2061087586927406 VHHEPQLSDK ddPTM_A459_Selumetinib_30min_R2 1 VHHEPQLSDK 10 0 O43852-5;O43852;O43852-3;O43852-13;O43852-14;O43852-9;O43852-11;O43852-10;O43852-6;O43852-2;O43852-4;O43852-12;O43852-7;O43852-8 O43852-5 CALU Calumenin 0 71.45100000000002 0.040078 2106200.0 10669.0 8132.8 12111.0 11081.0 11350.0 9423.1 10093.0 11155.0 8314.4 9277.7 False True 10076.059691390921 8756.559608926344 11331.79144545978 9571.7486842088 9924.111529712593 10721.046490614977 10562.34449890009 11187.459203190336 9977.512323746216 9009.828694640484 1.1183408733824969 0.9718896891053214 1.2577144171676116 1.062367444333606 1.1014761618737514 1.1899278947437053 1.1723135763039672 1.2416949958044396 1.1074031107474174 1.0 13.13728396076282 -6.739613570964222 23.511525731962468 1.159251692592369 1.1015186886998056 0.031116044770419737 0.08886760430240682 308.0202813722924 331808.2469021986 0.028227864550391075 0.02819715952038989 1.8213207230393551e-07 6.739613570964222 -0.05773300389256342 VHIDIGADGR ddPTM_A459_Selumetinib_30min_R1 3 VHIDIGADGR 10 0 P31942;P31942-4;P31942-3;P31942-2;P31942-5;P31942-6 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 ;; 164.66 0.00052224 20508400.0 10937.400000000001 12186.1 14114.8 14274.6 13281.5 10981.900000000001 11929.6 11089.7 7065.299999999999 10759.0 False True 11192.220139524337 10759.345746835806 12198.0876870466 11781.809077428305 12080.190670039281 10871.432056767402 11029.74066742394 10795.565131577687 11989.298070904873 12140.02245153473 0.9219274662963598 0.8862706629900523 1.0047829594832858 0.9704931868506437 0.9950715262896498 0.895503455629363 0.9085436795077401 0.8892541323276483 0.9875845056109593 1.0 13.567483469239244 -7.895599653769343 0.004121797717352092 1.894837189314799 9.731252859964811e-08 0.07383884598226809 0.045576913971307295 26537.44435285078 111.75120648016363 25672.065831088734 25694.170724309857 1.2717459001559869e-08 7.895599653769343 -1.8948370920022704 VHIDIGADGR ddPTM_A459_Selumetinib_30min_R2 1 VHIDIGADGR 10 0 P31942;P31942-4;P31942-3;P31942-2;P31942-5;P31942-6 P31942 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 151.83 0.00092321 6043200.0 42192.0 41864.0 42676.0 53719.0 53559.0 33893.0 33711.0 40028.0 36425.0 43400.0 False True 39847.137547958206 45074.83418602359 39930.27262211555 46402.37952955618 46830.43959646491 38561.45309997914 35278.62829707925 40144.47485300788 43711.01779953529 42146.9292332579 0.9454339443670563 1.0694689982409276 0.9474064504468526 1.100967030664249 1.1111234068153957 0.9149291253596363 0.837039113854138 0.9524887241685477 1.0371103801565495 1.0 15.363139901788337 -6.782215104955942 24.985049972100963 0.938389346447384 1.035613463002792 0.2611804251716693 0.07182940965268314 317.6538495096927 382010.4539608956 0.026171978734850002 0.023105532123286823 1.6511437883339445e-07 6.782215104955942 0.09722411655540797 VHIEIGPDGR ddPTM_A459_Selumetinib_30min_R1 4 VHIEIGPDGR 10 0 P52597;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P55795 P52597;P31943;P55795 HNRNPF;HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 0 ;;; 157.75 0.00068418 86512000.0 24922.6 28533.699999999997 28905.300000000003 31435.5 28941.0 24291.8 27100.2 24380.5 14075.3 20994.7 False True 25503.24808906225 25192.961139042764 24980.11902544761 25945.880042417815 26323.29165994855 24047.446547189687 25056.01009550381 23733.849940974935 23884.756080761945 23689.574250695816 1.0765600014239667 1.0634619631588689 1.0544773308753697 1.095244674633852 1.1111762238266218 1.0151067424305171 1.057680894994044 1.0018689947658228 1.0082391446971823 1.0 14.531964650228513 -7.390837476747708 1.2251322320461695 1.0020061790633459 1.07624563629252 0.6338451489581483 0.0230475367110821 0.3208438222988969 0.9196353580317546 0.016621307005653976 0.008537036994709955 4.065954583217479e-08 7.390837476747708 0.07423945722917402 VHIEIGPDGR ddPTM_A459_Selumetinib_30min_R2 4 VHIEIGPDGR 10 0 P52597;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P55795 P52597;P31943;P55795 HNRNPF;HNRNPH1;HNRNPH2 Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein H2 0 ;;; 144.77 0.001327 53815400.0 205729.0 187569.0 204382.0 222952.0 222309.0 165764.0 174921.0 187204.0 160162.0 196756.0 False True 194295.40577843876 201954.93917060609 191232.28463429626 192585.55298634752 194380.55595232395 188596.48634422838 183055.17309938584 187748.7326467093 192198.87530018296 191075.1430465186 1.016853383860276 1.0569398821354734 1.0008224072753378 1.0079047955466462 1.0172990209668487 0.9870278432727025 0.9580271414729217 0.9825910877429019 1.0058811012031574 1.0 17.54378058485058 -5.974763001055041 0.8990834025350624 0.9851080947433348 1.0355150376860325 0.4472283689363221 0.018279873596802162 0.5888689119647298 0.9532903070907442 0.008555915814048165 0.020174599140816003 1.0598319285308552e-06 5.974763001055041 0.05040694294269765 VHISGS(ph)VDGLDK ddPTM_A459_Selumetinib_30min_R1 1 VHISGSVDGLDK 12 0 J3KP75 J3KP75 PHACTR2 Phosphatase and actin regulator 1 VHIS(0.204)GS(0.796)VDGLDK 84.84200000000001 0.026495 0.0 4329.6 4914.6 3983.4 4758.0 7823.3 4812.2 7143.4 5107.1 1991.5 3093.2 True False 4430.471256064931 4339.196347264445 3442.476159249964 3927.104618721639 7115.6838963158 4763.793637128008 6604.567586815667 4971.643117801241 3379.430046594914 3490.242350319477 1.2693878565937953 1.2432364035887822 0.9863143626501637 1.125166743324335 2.038736334645779 1.3648890704371741 1.89229483912804 1.424440660215519 0.968250828280042 1.0 11.76911150031334 VHISGS(ph)VDGLDK ddPTM_A459_Selumetinib_30min_R2 4 VHISGSVDGLDK 12 0 J3KP75 J3KP75 PHACTR2 Phosphatase and actin regulator 1 VHIS(0.007)GS(0.993)VDGLDK;VHIS(0.004)GS(0.996)VDGLDK;VHIS(0.011)GS(0.989)VDGLDK;VHIS(0.004)GS(0.996)VDGLDK 125.36 0.0019106 8973300.0 114065.0 95027.0 162170.0 206013.0 211848.0 156648.0 122299.0 150293.0 150889.0 157715.0 True False 107725.72393837337 102315.26534003607 151736.1587573453 177953.67400775262 185233.76029485068 178224.84009103733 127986.14583087101 150730.32774765452 181071.016190915 153161.35815721826 0.7033479281882199 0.6680227086717964 0.9906947847876225 1.1618705667593086 1.2094027013309094 1.1636410269233295 0.8356294784190592 0.9841276517862403 1.1822238870789314 1.0 17.22469283288192 -5.339381292516606 3.8446753164833956 1.0750326489414452 0.6818159676382253 0.6665669467635937 0.1087333506171902 0.13905894117464965 3.8895815009703414 0.03185845927635597 0.07473445659950351 4.5773983368576525e-06 5.339381292516606 -0.39321668130321996 VHLENMGSHDIVDGNHR ddPTM_A459_Selumetinib_30min_R1 2 VHLENMGSHDIVDGNHR 17 0 A0A087WUZ3;Q01082;Q01082-2;F8W6C1;O15020-2;O15020;A4QPE4;P11277-3;P11277;P11277-2;Q01082-3 A0A087WUZ3;Q01082-3 SPTBN1;SPTBN2;SPTB Spectrin beta chain, non-erythrocytic 1;Spectrin beta chain, non-erythrocytic 2;Spectrin beta chain, erythrocytic 0 ; 100.68 0.0015771 11390300.0 1943.8400000000001 3158.1 2471.94 2793.7 2752.6000000000004 1902.31 2044.27 2061.87 1220.58 1612.6100000000001 False True 1989.1276899457825 2788.3481838391403 2136.264125394477 2305.8327392439337 2503.627816011001 1883.1744885592843 1890.0690680487796 2007.1825097023439 2071.2351123639573 1819.6042016515862 1.0931650345390092 1.5323926935914205 1.1740268149828796 1.2672166491762418 1.375918902439636 1.034936326729735 1.038725381230289 1.1030874230123782 1.1382888160425082 1.0 10.829408955738051 -6.7689725276319965 24.99979071314831 1.0679328816355265 1.2945442513238274 0.4905350235898637 0.11478725192182448 144.886005981038 480821.2258956372 0.03816119024887632 0.03430301340399788 1.702266186032949e-07 6.7689725276319965 0.22661136968830098 VHLVGIDIFT(ph)GK ddPTM_A459_Selumetinib_30min_R1 2 VHLVGIDIFTGK 12 0 P63241;P63241-2;I3L397;I3L504;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 P63241 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 VHLVGIDIFT(1)GK;VHLVGIDIFT(1)GK 117.08 0.0065807 7534600.0 6256.5 9733.1 11054.3 10862.3 11382.400000000001 8736.4 10048.8 8965.5 3867.9 8565.3 True False 6402.264276970212 8593.54412720457 9553.186776923456 8965.403215624214 10352.863929725938 8648.519748016526 9290.810925664702 8727.70581595171 6563.5437997612225 9664.739688087218 0.6624352526392054 0.8891645718918838 0.9884577428090212 0.9276404233292482 1.0711994594626177 0.8948528389933474 0.9613100016668403 0.9030461344664565 0.6791226677166963 1.0 13.238515159802873 -4.774004323056743 3.8552488961950457 0.9303833817592437 0.6341614107586279 0.39970149761192597 0.09707528048331625 0.25586870919073423 6.874407658952958 0.024561898467592033 0.2174047643328408 1.6826573114695768e-05 4.774004323056743 -0.29622197100061587 VHPAVVIR ddPTM_A459_Selumetinib_30min_R2 1 VHPAVVIR 8 0 C9JD32;J3KT29;P62829;J3QQT9;J3KTJ3 C9JD32 RPL23 60S ribosomal protein L23 0 119.56 0.010986 5834100.0 38692.0 38982.0 37069.0 35675.0 33273.0 32094.0 26992.0 26527.0 27986.0 39407.0 False True 36541.65353634807 41971.79405311412 34684.02089767556 30816.003457192382 29092.948275605926 36514.65717967517 28247.18148363334 26604.18917821875 33583.98199417416 38269.21751831781 0.9548576089609664 1.0967507771232596 0.9063164377759704 0.805242580213251 0.7602180071144751 0.9541521762810329 0.7381175606768715 0.6951850835592466 0.8775716926560875 1.0 15.223896782411531 -5.503741438899836 4.0603110148935215 0.8193538659372381 1.0246139297690537 0.387047149156896 0.09504954864625928 0.18863988368756068 7.052957230748928 0.025218322613547867 0.051602608793205516 3.135151709377365e-06 5.503741438899836 0.2052600638318156 VHPVS(ph)TMIK ddPTM_A459_Selumetinib_30min_R2 2 VHPVSTMIK 9 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 VHPVS(0.787)T(0.213)MIK;VHPVS(0.824)T(0.176)MIK 93.839 0.015899 6577100.0 70461.0 59720.0 65467.0 66157.0 67657.0 55482.0 55473.0 63245.0 46520.0 61667.0 True False 66545.05969773135 64300.33196993422 61254.92449508017 57146.3024728095 59157.32279874589 63124.14188454967 58052.60441766414 63429.03247922664 55825.299877402394 59886.51347989205 1.1111860723044935 1.0737030465385864 1.0228500698349654 0.9542432703482959 0.9878237913885068 1.0540627299290801 0.969376927196744 1.0591538694354623 0.9321848381797468 1.0 15.869943522356872 -5.206234612797446 2.447305954325375 0.9972088836865628 1.1059805070482507 0.5196572444378632 0.03783943930723724 0.24518471913375386 2.739090084037308 0.00988918489751855 0.037124073150208825 6.2196419942946084e-06 5.206234612797446 0.10877162336168789 VHS(ph)PCPTSGSEK ddPTM_A459_Selumetinib_30min_R1 2 VHSPCPTSGSEK 12 0 X6RLP6;Q96LT9-2;Q96LT9 X6RLP6 RNPC3 RNA-binding protein 40 1 VHS(0.975)PCPT(0.024)S(0.001)GSEK;VHS(0.763)PCPT(0.217)S(0.013)GS(0.007)EK 152.4 0.00049681 10885300.0 3820.4 4177.9 2776.8 2946.5 3295.6000000000004 2935.7 4514.1 3831.5 1783.5900000000001 3889.7 True False 3909.4078867956537 3688.7495257469814 2399.7258118705886 2431.949087655171 2997.513561885439 2906.1695234023314 4173.597802677238 3729.8761735339913 3026.6219617405095 4388.980883886478 0.8907324935381904 0.8404569587645512 0.5467615091878941 0.5541033675001246 0.682963458075287 0.6621513285856225 0.9509264025277511 0.849827390961693 0.6895956126973174 1.0 12.099670271245554 -7.247415576693843 24.380060107578796 0.8600729693537079 0.68889965652927 0.3156727994147551 0.12642450302306615 785.3606777184939 1365333.5205073277 0.05197838372310435 0.04004350335228079 5.656977134244368e-08 7.247415576693843 -0.17117331282443793 VHS(ph)PCPTSGSEK ddPTM_A459_Selumetinib_30min_R2 4 VHSPCPTSGSEK 12 0 X6RLP6;Q96LT9-2;Q96LT9 X6RLP6 RNPC3 RNA-binding protein 40 1 VHS(1)PCPTSGSEK;VHS(1)PCPTSGSEK;VHS(0.998)PCPT(0.002)SGSEK;VHS(0.939)PCPT(0.047)S(0.014)GSEK 170.95 0.00028576 25762500.0 184504.0 131154.0 156468.0 174105.0 184927.0 145446.0 191307.0 204193.0 149338.0 148759.0 True False 174250.00630803185 141213.09007342157 146401.0192294774 150391.59865212286 161694.8169916443 165479.86627266888 200203.15456762916 204787.16782402934 179209.77285235454 144463.9411477005 1.206183390288916 0.9774971453190852 1.0134087306935398 1.0410320904810557 1.1192745795736452 1.1454752304139453 1.3858347832483724 1.4175659766519462 1.240515601530833 1.0 17.14034990889767 -6.97536502536688 2.822158521498711 1.294524056712081 1.0600501889842067 0.3286055057171213 0.12211150781410364 0.2524279780939012 4.0896529727849265 0.047379612348555186 0.03878351948025439 1.0583637943829853e-07 6.97536502536688 -0.23447386772787437 VHS(ph)PPASLVPR ddPTM_A459_Selumetinib_30min_R1 1 VHSPPASLVPR 11 0 Q9BTE3;Q9BTE3-2;Q9BTE3-3 Q9BTE3 MCMBP Mini-chromosome maintenance complex-binding protein 1 VHS(1)PPASLVPR 109.6 0.006154 7312200.0 1262.0 1655.9 1312.1 1311.4 1398.1 1403.9 1425.3 1470.3 845.27 1158.0 True False 1291.402144575468 1462.0264581929755 1133.9240268493952 1082.3886080268087 1271.6421018546027 1389.7780406392121 1317.788473484386 1431.3028677925165 1434.361453921809 1306.640579875194 0.9883376993379606 1.118920138185685 0.8678163255558036 0.828375166589572 0.9732149157468123 1.0636268779988138 1.0085317215620664 1.0954067169176929 1.0977475183411298 1.0 10.351646635480105 -6.696057023109743 5.029614711272509 1.056347911121452 0.9508251047076234 0.2847104363931745 0.0777559498604248 0.29405011087838906 14.323933926344106 0.02885068916696122 0.028394757442179657 2.0134598640931404e-07 6.696057023109743 -0.10552280641382861 VHS(ph)PPASLVPR ddPTM_A459_Selumetinib_30min_R2 3 VHSPPASLVPR 11 0 Q9BTE3;Q9BTE3-2;Q9BTE3-3 Q9BTE3 MCMBP Mini-chromosome maintenance complex-binding protein 1 VHS(1)PPASLVPR;VHS(1)PPASLVPR;VHS(1)PPASLVPR 133.15 0.0012408 23566000.0 38867.7 32214.8 44294.0 41982.2 54133.0 37321.5 37269.5 44280.0 40562.0 45913.0 True False 36707.5888337309 34685.57157309172 41444.17226366077 36264.15193666551 47332.3285848398 42462.19785415484 39002.605598113216 44408.847469051354 48675.5333969732 44587.37239369979 0.8232732018744772 0.7779236521682269 0.9295047014144489 0.8133278547221511 1.0615635334350375 0.9523368517709457 0.8747455502361986 0.9959960653641553 1.0916887626204022 1.0 15.444347561343529 -5.27171437263028 0.39701018924125403 1.020520661499647 0.680256615445472 0.5177358571399016 0.0709391528127222 3.3420893834782013 0.5561175891290608 0.06393981915654437 0.5220901253625279 5.349160480292919e-06 5.27171437263028 -0.34026404605417493 VHSAVITVPAYFNDSQR ddPTM_A459_Selumetinib_30min_R1 1 VHSAVITVPAYFNDSQR 17 0 P54652 P54652 HSPA2 Heat shock-related 70 kDa protein 2 0 132.03 0.010229 11530000.0 2865.3 3227.7 3385.8 3659.5 3847.5 2959.0 2962.5 2940.4 1743.8 2635.9 False True 2932.05591509674 2849.79938348298 2926.0269568681374 3020.4370223227897 3499.4943043312974 2929.2351465570387 2739.036239877566 2862.411040234723 2959.101237887128 2974.243440840265 0.9858157119339208 0.9581594244611907 0.9837886558611673 1.0155312039519786 1.176599822421611 0.9848673132584901 0.9209186451475372 0.9623997151443837 0.994908889183308 1.0 11.538307020996386 -10.165342982218997 12.264652410838348 0.9999977013013877 0.9985656751874168 3.239994842918481e-05 0.06444814105705483 0.0 0.0 0.06812966023380232 0.01652386972831825 6.833717441894363e-11 10.165342982218997 -0.0014320261139708634 VHSEAIS(ph)PAPEEK ddPTM_A459_Selumetinib_30min_R1 2 VHSEAISPAPEEK 13 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 VHS(0.001)EAIS(0.999)PAPEEK;VHS(0.045)EAIS(0.955)PAPEEK 174.47 0.00012262 19831100.0 6545.4 7170.5 7910.599999999999 8698.8 6759.7 6050.2 6593.7 6719.4 4243.0 5188.0 True False 6697.895084868675 6330.974526524986 6836.383969815423 7179.717876699402 6148.286328521965 5989.340481142072 6096.331900381676 6541.179684312746 7200.06110354116 5853.930335399404 1.1441706171946937 1.0814912654906124 1.1678280365714309 1.226478189069454 1.05028348071424 1.0231314925160329 1.0414083446665638 1.1173996459707531 1.2299533289628586 1.0 12.515189861742568 -6.289040679828843 24.951729980415628 1.0784234168173261 1.150658856046994 0.236863280913711 0.06835164442065148 1229.6206171607455 1111580.8553823184 0.022524410189855952 0.02554379370234035 5.139955040021492e-07 6.289040679828843 0.0722354392296678 VHSEAIS(ph)PAPEEK ddPTM_A459_Selumetinib_30min_R2 1 VHSEAISPAPEEK 13 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 VHSEAIS(1)PAPEEK 170.74 0.00021987 6216000.0 32627.0 28122.0 36017.0 35714.0 40437.0 28033.0 34502.0 36287.0 30946.0 31049.0 True False 30813.721956229427 30278.86697351794 33699.70543234458 30849.691589913637 35356.94254863331 31894.29129176275 36106.41136441601 36392.58916236377 37136.06470348436 30152.534695009792 1.0219280822626517 1.004189773091582 1.1176408807158038 1.0231210046503727 1.1726026652905186 1.0577648484404603 1.1974585795068027 1.206949582530012 1.2316067315438768 1.0 14.879991663207715 -6.152343831806558 0.8138832326723321 1.1669034362305322 1.0173786138813594 0.28899633400233005 0.07384589532105261 0.7882115790871002 1.0959561566762348 0.03729130818765745 0.07290921906253663 7.041353828502358e-07 6.152343831806558 -0.14952482234917275 VHVGDEDFVHLR ddPTM_A459_Selumetinib_30min_R1 3 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 ;; 212.82 1.9275e-06 71346200.0 16130.4 12255.8 12858.3 12064.599999999999 14061.3 9394.5 11937.599999999999 12101.1 6528.199999999999 10775.7 False True 16506.20693570533 10820.885238433157 11112.213485586135 9957.74409059038 12789.45789772415 9299.999859523525 11037.137220983104 11780.139518087482 11077.878599136791 12158.866059206506 1.3575449269142235 0.8899584209367739 0.9139185703235984 0.8189697988366711 1.0518627177441575 0.764873945829982 0.9077439596125787 0.9688518206159317 0.911094714358564 1.0 13.569721068278247 -4.759912588060257 24.997000428445983 0.9096263090669019 1.3575454773463254 0.7419152270686868 0.07841497117143484 18.35095642692514 300346.64154151175 0.018412988639299018 0.11307817485465396 1.7381506370841747e-05 4.759912588060257 0.44791916827942346 VHVGDEDFVHLR ddPTM_A459_Selumetinib_30min_R2 4 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 ;;; 172.61 0.00012275 37460800.0 101963.0 69258.1 94407.0 105830.0 103150.0 77071.1 77983.0 89675.0 71148.5 74935.0 False True 96296.30465022894 74569.97357010888 88332.95640256975 91415.77143306706 90191.37482729994 87686.94444321259 81609.36402038294 89935.93940350451 85380.18805518816 72771.43184548791 1.3232707150065461 1.0247149421003523 1.2138411209239757 1.2562041053028306 1.2393788680535922 1.2049638466561174 1.1214478257575058 1.2358687622700784 1.173265193358732 1.0 16.151084576899606 -8.567196887389594 19.15726084720964 0.9999999982571252 1.1977736104147112 0.3831959756065101 0.07643996133057242 1028.893253527774 444757.30107988993 0.0713386113072328 0.01841955022831599 2.7089632450661025e-09 8.567196887389594 0.19777361215758604 VHVQFFDDS(ph)PTR ddPTM_A459_Selumetinib_30min_R1 3 VHVQFFDDSPTR 12 0 P52701-2;P52701;A0A087WWJ1;F8WAX8;A0A494C0M1;C9J7Y7;C9JH55;C9J8Y8 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 VHVQFFDDS(1)PTR;VHVQFFDDS(0.985)PT(0.015)R;VHVQFFDDS(0.934)PT(0.066)R 171.81 0.00016568 79571000.0 15819.4 17833.7 16963.300000000003 17980.600000000002 16191.8 14744.4 16066.099999999999 16233.5 8216.0 12629.0 True False 16187.961240805984 15745.722113337808 14659.77703273709 14840.625747664199 14727.254548894467 14596.084722844062 14854.22114210868 15802.934846160519 13941.951927102094 14250.055166877224 1.135992882219377 1.1049586776293405 1.028752300328789 1.0414433890866397 1.0334875462886939 1.0242826818503235 1.0423974481611675 1.1089735907053049 0.9783788037192106 1.0 13.79867988400761 -5.128187171455055 3.280528107142899 1.0364325834850099 1.1318104151103339 0.5506175310591999 0.03217661805947158 0.18736059435765542 3.6541910763005077 0.008130451055548299 0.028382355648366053 7.444110798128681e-06 5.128187171455055 0.09537783162532398 VHVQFFDDS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 6 VHVQFFDDSPTR 12 0 P52701-2;P52701;A0A087WWJ1;F8WAX8;A0A494C0M1;C9J7Y7;C9JH55;C9J8Y8 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 VHVQFFDDS(0.777)PT(0.223)R;VHVQFFDDS(0.999)PT(0.001)R;VHVQFFDDS(0.989)PT(0.011)R;VHVQFFDDS(0.999)PT(0.001)R;VHVQFFDDS(0.991)PT(0.009)R;VHVQFFDDS(0.764)PT(0.236)R 183.28 0.0001043 79050900.0 139956.0 113788.0 137472.0 146282.0 157417.0 123061.4 119481.90000000001 126519.2 110504.8 133611.9 True False 132177.80580825836 122515.1737139127 128627.20118819628 126358.13924947468 137640.8691341645 140011.99080983593 125038.0450988934 126887.34992561892 132608.84776208908 129754.17728159293 1.01867861657668 0.9442098611440454 0.991314529389286 0.9738271391082219 1.0607817953749255 1.0790557479007512 0.9636533306171364 0.9779057027986667 1.0220006056090274 1.0 16.985421459620575 VHVQFFDDSPT(ph)R ddPTM_A459_Selumetinib_30min_R1 1 VHVQFFDDSPTR 12 0 P52701-2;P52701;A0A087WWJ1;F8WAX8;A0A494C0M1;C9J7Y7;C9JH55;C9J8Y8 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 VHVQFFDDS(0.295)PT(0.705)R 153.14 0.00064671 14524000.0 4303.9 4837.0 5413.5 5593.0 4939.7 4178.2 4368.5 4487.4 2536.9 3880.1 True False 4404.172496068427 4270.681791339706 4678.376434226966 4616.287543612885 4492.905007174868 4136.171101502066 4038.9805279004713 4368.379574870531 4304.9340121549785 4378.148630374564 1.0059440343147137 0.9754538166454017 1.0685741461058431 1.0543926059490465 1.026211165149614 0.9447306271893753 0.9225316152765979 0.9977686788803244 0.9832772652550806 1.0 12.096105216948086 -6.747437196743711 24.598004001491077 0.9665765568650417 1.0272304591219121 0.43286934894562035 0.03219976038084825 192.73247655420784 338577.3353801426 0.011517457609197618 0.011460306273861248 1.7888041890955894e-07 6.747437196743711 0.060653902256870396 VIAHTQMR ddPTM_A459_Selumetinib_30min_R1 3 VIAHTQMR 8 0 H7C422;H7C3M2;P39023;B5MCW2;G5E9G0 H7C422;P39023 RPL3 60S ribosomal protein L3 0 ;; 152.47 0.0014 32355500.0 8386.8 8995.8 8705.5 9160.7 8489.3 7453.9 7972.0 8108.299999999999 5567.1 6913.0 False True 8582.196122128 7942.567553966042 7523.340915888581 7560.955712636252 7721.444313907651 7378.9205335997 7370.665621705975 7893.241544529725 9446.96209510347 7800.350888322296 1.1002320594290425 1.018232085668948 0.9644874985241472 0.9693096914339538 0.9898842275758679 0.9459728977893151 0.9449146233588555 1.0119085227751092 1.2110945046390507 1.0 12.929323307798049 -8.024831805209743 23.723048324878064 1.107532096023172 0.9872788801755429 0.3374184403058287 0.06352549636278594 414.15606725308277 395659.5652710033 0.04110102803835671 0.015723954042502222 9.444265656493213e-09 8.024831805209743 -0.12025321584762916 VIAHTQMR ddPTM_A459_Selumetinib_30min_R2 2 VIAHTQMR 8 0 H7C422;H7C3M2;P39023;B5MCW2;G5E9G0 H7C422;P39023 RPL3 60S ribosomal protein L3 0 ; 176.41 0.00021899 18365500.0 91889.0 77514.0 78947.0 102796.0 112534.0 78547.0 85115.0 93899.0 74755.0 79455.0 False True 86782.17724081181 83459.07455320636 73867.6359709946 88795.00746700914 98396.47285327547 89366.13627132613 89073.01615217298 94172.23054418371 89708.08882921789 77160.92770111754 1.124690692897863 1.081623524233465 0.9573191791721388 1.1507768259468854 1.2752111176580678 1.1581786136305334 1.154379798247072 1.2204652451686346 1.1626102938614438 1.0 16.235582868475035 -5.9761673362642505 23.997656429402483 1.1759794057338147 1.0567181781068897 0.2750783141392563 0.07673168721136378 162.3251584154812 163446.78901428796 0.020736609033563166 0.03075514834399072 1.05641038953744e-06 5.9761673362642505 -0.11926122762692493 VIAIDSDAES(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 VIAIDSDAESPAK 13 0 P28749 P28749 RBL1 Retinoblastoma-like protein 1 1 VIAIDSDAES(1)PAK 164.92 0.00036256 9831800.0 3502.6 4226.5 3842.7 3921.4 2948.1 3436.1 3337.1 3210.8 1962.3 3001.1 True False 3584.203765126809 3731.6594151534587 3320.8824464401873 3236.601103794666 2681.4448755293306 3401.53595372918 3085.379860285377 3125.6391538517396 3329.8797792785367 3386.3204181895035 1.0584360965590798 1.101980602635527 0.980675788564538 0.9557870207465823 0.7918461764947115 1.0044932356247056 0.9111305131411562 0.9230193153200968 0.9833327529764172 1.0 11.725502774098304 -5.4571816627563505 2.8068977454146204 0.9312206337924889 1.0807266822819193 0.4701723347819544 0.05878537729740074 0.21680226056512758 3.318613733719237 0.016019661180899977 0.03789008709420682 3.489943027355235e-06 5.4571816627563505 0.1495060484894304 VIAIDSDAES(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 VIAIDSDAESPAK 13 0 P28749 P28749 RBL1 Retinoblastoma-like protein 1 1 VIAIDSDAES(1)PAK 139.3 0.00094237 3416400.0 21961.0 15211.0 23960.0 23822.0 22723.0 18249.0 20347.0 21788.0 13188.0 22210.0 True False 20740.495536848448 16377.634788926143 22418.439685675523 20577.402504757876 19868.33359380259 20762.634102071777 21293.175816815634 21851.399472802437 15825.968503507795 21568.73959148981 0.9615997934822229 0.7593227559475995 1.03939498136094 0.9540382467632426 0.9211634045432058 0.9626262125332492 0.9872239277819042 1.01310507181533 0.7337456338780273 1.0 14.396654252003476 -5.266883744826611 24.999158882556067 0.9525731862081224 0.8604612764885919 0.13590100098524738 0.09169809263357671 772.4281143970536 3546811.6827118886 0.022750295616385505 0.04971768495240456 5.408990954561607e-06 5.266883744826611 -0.09211190971953043 VIAIDSDAES(ph)PAKR ddPTM_A459_Selumetinib_30min_R1 3 VIAIDSDAESPAKR 14 1 P28749 P28749 RBL1 Retinoblastoma-like protein 1 1 VIAIDSDAES(1)PAKR;VIAIDSDAES(1)PAKR;VIAIDSDAES(1)PAKR 161.49 0.00050776 62364000.0 10037.8 11056.3 13752.8 13301.7 9607.1 11893.1 10096.2 9786.6 6832.3 8922.3 True False 10271.661209841222 9761.823256065582 11885.245298722935 10978.807798833453 8738.13950127127 11773.466212070813 9334.635505502752 9527.027576643028 11593.91408855157 10067.564115561703 1.0202727384635217 0.969631098845099 1.1805482599660422 1.0905128264207642 0.8679497245778145 1.1694453670150708 0.9271990124278381 0.9463091038990104 1.1516106533287975 1.0 13.297427039705813 VIAIDSDAES(ph)PAKR ddPTM_A459_Selumetinib_30min_R2 1 VIAIDSDAESPAKR 14 1 P28749 P28749 RBL1 Retinoblastoma-like protein 1 1 VIAIDSDAES(1)PAKR 105.63 0.0029674 10731000.0 28448.0 26408.0 32352.0 30730.0 29175.0 17080.0 22388.0 31278.0 18204.0 29196.0 True False 26866.974046366944 28433.408684896574 30270.50754219428 26544.5209877932 25509.775672190735 19432.61496319721 23429.086360980393 31369.013801648347 21845.308662257787 28353.035619681974 0.9475872145315035 1.0028347252228191 1.0676284524956208 0.9362144266967538 0.8997193815283215 0.6853804024323791 0.8263343183160431 1.1063723201431297 0.7704751249666302 1.0 14.791215585228718 -6.062275052227422 3.3716195088807326 0.8748029095387742 1.0056753662203626 0.19380367168389012 0.11258408121646697 0.4061062797887514 9.102078222967497 0.03519948445771955 0.04909734533972389 8.664129756250575e-07 6.062275052227422 0.13087245668158842 VIDGPHSGR ddPTM_A459_Selumetinib_30min_R2 1 VIDGPHSGR 9 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 0 86.898 0.046697 757400.0 2607.7 2353.9 2921.0 2826.9 2216.3 693.96 1849.2 2924.3 2369.0 3627.6 False True 2462.774473450194 2534.4365610185564 2733.066040144335 2441.8713433254998 1937.86858002661 789.5466908583338 1935.1914641202845 2932.809228856073 2842.8661953905016 3522.861762363282 0.6990834837067414 0.7194254932439788 0.7758084831324408 0.6931499184593014 0.5500836282393912 0.2241208267930085 0.5493237017685524 0.8325076107694395 0.8069763695420704 1.0 11.782532149030635 -7.837012452920622 5.309294784118296 0.8743438830893099 0.6000777881195213 0.41447764182738334 0.15199807965821976 0.24940255420673 12.326859173976786 0.09772928431286722 0.04615904894312523 1.4554173474784979e-08 7.837012452920622 -0.2742660949697886 VIEDNEYT(ph)AR ddPTM_A459_Selumetinib_30min_R2 1 VIEDNEYTAR 10 0 H0Y3C5;J3KPD6;P08631-3;P08631-2;P08631-4;P08631;P07948;P07948-2 H0Y3C5;P07948 HCK;LYN Non-specific protein-tyrosine kinase;Tyrosine-protein kinase HCK;Tyrosine-protein kinase Lyn 1 VIEDNEY(0.173)T(0.827)AR 96.668 0.039047000000000005 0.0 8520.6 5853.2 8354.5 10287.0 11112.0 7462.0 6609.8 7315.9 8464.2 8807.9 True False 8047.059162664309 6302.121618995629 7816.98056569183 8885.89285393519 9716.011217459585 8489.822766708294 6917.1687970702305 7337.188057787558 10157.276509507936 8553.593041327476 0.9407811575538138 0.7367806240659739 0.9138826839111195 1.0388491492408132 1.135898232534068 0.9925446213876356 0.808685749210804 0.8577901733619141 1.1874865288110055 1.0 13.062314853669031 -5.526251677930345 6.872072006376487 0.9931182742250999 0.8350450458853369 0.24674932741831923 0.11553717970719897 0.19159558012750635 50.386034893936426 0.03277642561099177 0.060664773902267675 2.9767908498614894e-06 5.526251677930345 -0.158073228339763 VIEEEWQQVDR ddPTM_A459_Selumetinib_30min_R1 1 VIEEEWQQVDR 11 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 192.12 0.00027829 4738800.0 382.32 520.53 381.72 482.86 515.83 422.34 518.81 398.4 304.15 436.18 False True 391.2273121347804 459.5861056121681 329.8845206378713 398.5375654047769 469.17326757718337 418.0916430540384 479.67574400367266 387.8331378144176 516.1203357629144 492.1679517529902 0.7949061102847469 0.9337993340997256 0.6702681868311371 0.8097592782814826 0.9532787860446724 0.8494897759289104 0.9746179983787585 0.7880097361744995 1.0486670940775629 1.0 8.943006907399413 -7.51701650245893 0.44932265714112457 1.0059597801005506 0.8010359367126039 0.33806028012328704 0.09116952956468055 1.2899903782036803 0.6174437599463451 0.09595065328441908 0.0840745563454432 3.0407694793616606e-08 7.51701650245893 -0.20492384338794678 VIET(ph)PENDFK ddPTM_A459_Selumetinib_30min_R1 3 VIETPENDFK 10 0 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 VIET(1)PENDFK;VIET(1)PENDFK;VIET(1)PENDFK 134.56 0.0048656 43811800.0 18200.5 18465.2 18519.4 19602.8 14853.3 15147.900000000001 15932.900000000001 14738.699999999999 9654.099999999999 14720.4 True False 18624.53623799191 16303.285799761416 16004.567199782541 16179.538970129579 13509.821637563098 14995.525879192759 14731.068525348624 14347.781797955224 16382.302592433824 16609.90672883835 1.121290838175252 0.9815398765277488 0.9635555130478362 0.9740896944375034 0.8133592715549185 0.9028061459946263 0.886884482004486 0.8638086915349384 0.9862970852202706 1.0 14.019756351572184 -3.967507647533903 0.8368620015878285 0.9059358265344265 1.7320400573706538 0.5410130295193258 0.055546918250690525 5.768051427691351 1.1566919797681898 0.019271578193317786 6.078827546620065 0.00010776862764444522 3.967507647533903 0.8261042308362273 VIET(ph)PENDFK ddPTM_A459_Selumetinib_30min_R2 2 VIETPENDFK 10 0 Q9H0G5;A0A024QZ33 Q9H0G5 NSRP1;CCDC55 Nuclear speckle splicing regulatory protein 1 1 VIET(1)PENDFK;VIET(1)PENDFK 122.46 0.010426 27220000.0 186328.0 185021.0 181771.0 187661.0 194736.0 154750.0 189601.0 157697.0 127372.0 183978.0 True False 175972.6356900824 199211.51576371767 170076.051757301 162101.2480667183 170271.52271807138 176065.407819366 198417.8221872542 158155.87216185645 152849.95907103366 178666.07710774912 0.9849247184397384 1.1149935062579233 0.9519213412556896 0.9072860986865404 0.9530153987507366 0.9854439671453987 1.1105511768056187 0.8852036979939764 0.855506325237407 1.0 17.446906213828946 -5.289234743512521 24.012515853648836 0.9567244269015637 1.049959117751763 0.21105480951172884 0.07256755345576968 623.4193164240129 538573.3480092288 0.01985299645755319 0.04134773544847271 5.137658773725187e-06 5.289234743512521 0.09323469085019942 VIGQDHDFSES(ph)SEEEAPAEASSGALR ddPTM_A459_Selumetinib_30min_R2 1 VIGQDHDFSESSEEEAPAEASSGALR 26 0 P23497-5;P23497-2;P23497-3;P23497;P23497-4;E9PHV6;P23497-7;P23497-6;H7C4B4;H7C1G8 P23497-5 SP100 Nuclear autoantigen Sp-100 1 VIGQDHDFS(0.257)ES(0.54)S(0.195)EEEAPAEAS(0.004)S(0.003)GALR 58.929 0.0047531000000000006 2256500.0 4690.6 4802.8 5365.3 6288.8 5864.7 5575.8 4852.8 4623.8 5082.6 5284.5 True False 4429.915229959536 5171.159316563968 5020.102439296954 5432.254591214899 5127.923954916779 6343.815837927108 5078.464815640777 4637.254492488702 6099.262019709484 5131.922754220076 0.8632076985797836 1.007645587087535 0.9782108343639486 1.0585222832412773 0.9992207990075437 1.2361479589127622 0.9895832534627806 0.903609565961491 1.1884945101120135 1.0 12.325283739785252 -3.7406947714905026 0.8740579980761932 1.0511696515343614 2.2543745793297145e-10 0.2601048085421903 0.093565187510409 16.93110028156527 2.5474492082986413 0.03179656867360705 26.11544248521519 0.0001816792082206951 3.7406947714905026 -1.051169651308924 VIGSGCNLDS(ph)AR ddPTM_A459_Selumetinib_30min_R2 4 VIGSGCNLDSAR 12 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;F5H5G7;F5H155;A0A087WUM2;G3XAP5;F5H245;Q6ZMR3;P07864;P00338;P00338-3;P00338-5;P00338-4;P00338-2 A0A5F9ZHM4;P00338 LDHB;LDHC;LDHAL6A;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase C chain;L-lactate dehydrogenase A chain 1 VIGSGCNLDS(1)AR;VIGSGCNLDS(1)AR;VIGSGCNLDS(1)AR;VIGSGCNLDS(1)AR 123.68 0.0032385 39214600.0 53938.1 49378.0 63991.0 68123.0 79009.0 25816.4 52024.2 55924.0 47346.0 60441.0 True False 50940.436333322046 53165.13382470551 59873.88872813286 58844.52988127027 69083.18307057822 29372.37476205415 54443.42838399663 56086.72958128344 56816.52295777068 58695.9112854226 0.8678702692869399 0.9057723555253723 1.0200691567251094 1.0025320093443133 1.1769675528955514 0.5004160276041053 0.9275506111363145 0.955547470905573 0.9679809328027474 1.0 15.840972389295482 -3.52339090283975 15.341792584330404 0.9295269236099472 0.3353851642563992 0.0 0.16443315576591658 0.0 0.0 0.03787896765696991 0.0 0.00029964642261699965 3.52339090283975 -0.594141759353548 VIGSGCNLDSAR ddPTM_A459_Selumetinib_30min_R1 2 VIGSGCNLDSAR 12 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;F5H5G7;F5H155;A0A087WUM2;G3XAP5;F5H245;Q6ZMR3;P07864;P00338;P00338-3;P00338-5;P00338-4;P00338-2 A0A5F9ZHM4;P00338 LDHB;LDHC;LDHAL6A;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase C chain;L-lactate dehydrogenase A chain 0 ; 183.85 0.0014455 57153000.0 4249.7 5876.4 5324.3 5938.1 5247.9 4745.0 5074.0 4360.1 2739.1 3885.8 False True 4348.709741523268 5188.388356135758 4601.289304286437 4901.12230694219 4773.228371592 4697.269608115293 4691.264094899162 4244.455984399204 4648.052644051286 4384.580280897265 0.9918189342933742 1.1833261164678688 1.0494252606876262 1.117808773691611 1.0886397478882979 1.0713156806776585 1.069945991258971 0.9680415712517445 1.0600906691803358 1.0 12.098223030262647 -7.60330573204544 6.477607996855608 1.0108816844689883 1.0870602717671858 0.3040536634579851 0.05034186635839683 0.24120532213044107 15.605618909019853 0.022216086054149237 0.012692381888961836 2.492839214979153e-08 7.60330573204544 0.07617858729819749 VIGSGCNLDSAR ddPTM_A459_Selumetinib_30min_R2 3 VIGSGCNLDSAR 12 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;F5H5G7;F5H155;A0A087WUM2;G3XAP5;F5H245;Q6ZMR3;P07864;P00338;P00338-3;P00338-5;P00338-4;P00338-2 A0A5F9ZHM4;P00338 LDHB;LDHC;LDHAL6A;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase C chain;L-lactate dehydrogenase A chain 0 ;; 218.55 5.792100000000001e-07 73660000.0 68436.0 71850.0 66796.0 68936.0 68339.0 61862.0 66850.0 57206.0 43682.4 58163.0 False True 64632.60109101417 77360.66396583673 62498.41808198589 59546.79787876703 59753.64386158847 70382.92897267599 69958.65746076204 57372.45998903687 52420.100588233894 56483.683064377416 1.1442703022277958 1.3696108286293005 1.106486239765087 1.0542300828878035 1.0578921313166514 1.2460754177884765 1.2385640182320705 1.0157351092641476 0.9280574095794701 1.0 15.785546543326248 -7.894833844661612 5.305186096674798 0.966675378254609 1.1719984662514045 0.48617640663359574 0.09156539554456436 0.19015442242517788 8.089579376907047 0.05627636861665728 0.02624499243735297 1.2739903997068657e-08 7.894833844661612 0.20532308799679544 VIHDNFGIVEGLMT(ph)TVHAITATQK ddPTM_A459_Selumetinib_30min_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VIHDNFGIVEGLMT(0.837)T(0.16)VHAIT(0.001)AT(0.002)QK;VIHDNFGIVEGLMT(0.492)T(0.492)VHAIT(0.005)AT(0.011)QK 112.57 2.2534e-06 14185800.0 1521.71 1453.65 2571.74 2246.28 2584.1 2252.74 2202.9 1856.11 1081.73 1811.11 True False 1557.1628822677776 1283.4559822164497 2222.5118335566367 1854.009365897864 2350.368611259911 2230.0794809242666 2036.7334794350359 1806.879933305017 1835.616803566718 2043.5836102053236 0.7619765956682956 0.628041826038866 1.0875561060764898 0.9072344075570206 1.1501210909710537 1.0912592319627212 0.9966479811562007 0.8841722571475681 0.8982342559413508 1.0 10.996885554965106 -5.259415028742312 24.999675061596758 1.0026825368255405 0.6950091919078291 0.6535961916579561 0.08936713949421629 107.48255709400627 1327330.4689786504 0.024384979417479035 0.0582421468690417 5.502815745231887e-06 5.259415028742312 -0.3076733449177115 VIHDNFGIVEGLMTTVHAIT(ph)ATQK ddPTM_A459_Selumetinib_30min_R1 1 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VIHDNFGIVEGLMTT(0.004)VHAIT(0.674)AT(0.322)QK 82.508 0.0015600999999999998 2890900.0 451.3 450.79 445.67 501.88 286.55 325.57 430.35 366.83 197.38 294.32 True False 461.8144119230655 398.01129723341455 385.150461890077 414.2360794543959 260.63160309451166 322.2950613939084 397.88835302322724 357.1004767682303 334.9394439351767 332.0988389195745 1.3905932746573217 1.1984724142013705 1.1597464873502619 1.2473276955801487 0.7848013077746101 0.970479338146556 1.1981022105277073 1.0752837255619268 1.0085534927639122 1.0 8.375468868689119 -5.055543023607362 0.9094461206529264 1.0296672588828726 1.4609524740138533 0.4801634455666808 0.11715440959219653 1.4864478728204826 1.2858772953260722 0.04538914241935292 0.5840435056532742 8.799479348722204e-06 5.055543023607362 0.4312852151309807 VIHDNFGIVEGLMTTVHAITAT(ph)QK ddPTM_A459_Selumetinib_30min_R1 1 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VIHDNFGIVEGLMT(0.037)T(0.043)VHAIT(0.079)AT(0.84)QK 71.501 0.010297 10669000.0 1208.8 938.28 1803.3 1556.3 1673.3 1427.3 1332.8 1393.5 766.23 1130.8 True False 1236.9626880846474 828.4257414054623 1558.4217648178594 1284.5214203691635 1521.9503104451085 1412.9426578847113 1232.2658229565636 1356.5398532740744 1300.2363467750051 1275.9491949247588 0.9694450946830917 0.6492623254128184 1.2213823019103498 1.0067183125147159 1.1927985193288642 1.1073659229574817 0.965764019334037 1.0631613379826366 1.0190345759430324 1.0 10.317355170434682 -5.263075476286837 24.999999999919893 1.073731537495518 0.8093537137654575 0.49399851474559997 0.1063273719164375 104.04978866687678 1589938.4105888274 0.026119544105895547 0.059363968224773245 5.456630217612315e-06 5.263075476286837 -0.2643778237300606 VIHDNFGIVEGLMTTVHAITATQK ddPTM_A459_Selumetinib_30min_R1 4 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ;;; 122.65 8.056900000000001e-08 26815670.0 9549.02 10928.009999999998 12488.750000000002 12482.869999999999 11189.21 9790.84 10029.96 10226.39 6416.99 7961.55 False True 9771.493586841552 9648.553508905974 10792.846345793296 10302.971086990703 10177.147931115478 9692.353038971447 9273.39204203288 9955.152917203775 10889.163351593832 8983.492494564209 1.0877165637700652 1.0740314543307277 1.2014087341113606 1.1468781315535015 1.1328720914804051 1.0789070113695938 1.032270249865972 1.1081606539135538 1.2121302887693979 1.0 13.133060712372052 -6.753879577937884 24.23416073980379 1.0896772196301105 1.1306133014355313 0.10583409857340254 0.06092062855480722 312.5444538684898 1001907.3735870031 0.020953606702932757 0.02055243272789375 1.7624646784745075e-07 6.753879577937884 0.04093608180542074 VIISAPS(ph)ADAPMFVMGVNHEK ddPTM_A459_Selumetinib_30min_R1 1 VIISAPSADAPMFVMGVNHEK 21 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VIIS(0.037)APS(0.963)ADAPMFVMGVNHEK 146.39 2.0969e-06 14746000.0 1924.5 2199.1 2272.9 2318.9 2682.0 1960.5 2738.3 4840.9 1055.1 2300.6 True False 1969.3371055748723 1941.6283496661456 1964.2526641460183 1913.9476461440943 2439.4135735455593 1940.7791499915754 2531.747826382024 4712.503606540698 1790.4276385449637 2595.904419741687 0.7586323635794098 0.7479583357924068 0.7566737238890625 0.7372951144073892 0.9397162526455038 0.747631205229312 0.97528545624725 1.8153609858292197 0.6897124658862153 1.0 11.342021549469388 -7.52847950299057 24.999552400295876 1.2305866719533198 0.7903450039672282 0.2884485819648239 0.2680602029135294 158.66580475210029 708206.2562398644 0.11627107399099751 0.06738920005848173 2.961559736190255e-08 7.52847950299057 -0.44024166798609166 VIISAPSADAPMFVMGVNHEK ddPTM_A459_Selumetinib_30min_R1 2 VIISAPSADAPMFVMGVNHEK 21 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 227.64 1.2818e-24 81074000.0 9094.5 10308.3 8885.2 9560.9 9594.4 8065.9 9015.4 9833.8 6412.3 8255.9 False True 9306.38415518351 9101.399443801347 7678.638642910021 7891.268295320658 8726.588214028901 7984.764369251239 8335.361119659818 9572.975679315818 10881.204764137876 9315.62518427601 0.9990080076312969 0.9770036110044167 0.8242751818601414 0.8471002363470412 0.9367689276248089 0.8571367150675886 0.8947720582113162 1.0276256815778928 1.168059528898225 1.0 13.185436878304406 -7.882119014098776 3.9466090774404 1.088117545798686 0.9019359706332921 0.5692782201205042 0.06475388476501803 0.15717906286742903 4.4557435381676775 0.040026680039823986 0.017843359780489815 1.3118403529084496e-08 7.882119014098776 -0.1861815751653939 VIISAPSADAPMFVMGVNHEK ddPTM_A459_Selumetinib_30min_R2 2 VIISAPSADAPMFVMGVNHEK 21 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 151.87 1.852e-06 104155000.0 240848.0 181818.0 261360.0 233700.0 268180.0 234192.0 211176.0 193521.0 209888.0 245380.0 False True 227462.6323509348 195762.85596298557 244544.38214725215 201869.65684501312 234488.8308403808 266449.8222166912 220996.10243730547 194084.11407087388 251871.46476071014 238295.24182619466 0.9545412262861679 0.8215139104865933 1.0262243604747066 0.8471409470787954 0.9840264918567273 1.1181499897972433 0.9274045958437279 0.8144691122806093 1.0569722787180853 1.0 17.862390619157246 -6.3253451450511795 24.96905123399565 0.97815461481042 0.913999556047992 0.1260711316769373 0.09107845407857554 517.2056874315242 202079.1438825527 0.02884635048864054 0.03270869056583198 4.7277538280416673e-07 6.3253451450511795 -0.064155058762428 VIKDFMIQGGDFTR ddPTM_A459_Selumetinib_30min_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 127.78 0.0031856 6994400.0 2489.4 2488.9 3665.7 3804.6 3647.5 2482.5 2974.6 3186.1 1922.7 2048.0 False True 2547.398176470817 2197.4984309417805 3167.9180742487824 3140.1980311871234 3317.5842690184277 2457.528303929656 2750.2235271357995 3101.5942780886476 3262.6814715481005 2310.880749209325 1.1023494731791836 0.9509354525081666 1.3708704247645385 1.358874979707002 1.43563629155401 1.0634595942566516 1.1901191907357387 1.342169767587474 1.4118779052811083 1.0 11.174227097490869 -5.259714299437921 24.99387328727689 1.282474440179924 1.0266424521437287 0.3166819625683508 0.1432376227192576 167.06667064044038 2420502.352953591 0.03707742937604676 0.08808650016473542 5.4990250817947575e-06 5.259714299437921 -0.2558319880361952 VIKSYAKFS(ph)AT(ph)PRYMT(ph)Y(ph)N ddPTM_A459_Selumetinib_30min_R1 1 VIKSYAKFSATPRYMTYN 18 3 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 4 VIKS(0.004)Y(0.017)AKFS(0.977)AT(0.95)PRY(0.581)MT(0.614)Y(0.857)N 42.277 0.047958 0.0 624.82 648.12 691.48 793.87 504.27 637.75 708.93 733.66 491.08 686.94 True False 639.3770903119207 572.2378090971863 597.5808140277564 655.2355072855291 458.65886753609965 631.3348140306698 655.4548393371821 714.2009535364606 833.3268929358932 775.1154403622335 0.8248798269495465 0.738261398624395 0.7709571799375974 0.8453392529238212 0.5917297523085792 0.8145042417625291 0.8456222198732997 0.9214123682050434 1.0751003651100741 1.0 9.598267381239594 -7.783261650512717 1.6382491277351545 1.0355818538190817 0.7598879378959311 0.7083810620870961 0.06939117624804712 0.20923286184191947 1.0597999428852152 0.053897251797757895 0.020848887395497957 1.6471697179527763e-08 7.783261650512717 -0.2756939159231506 VILAS(ph)PETSSAK ddPTM_A459_Selumetinib_30min_R2 2 VILASPETSSAK 12 0 P49116;P49116-2;C9JKS0 P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 1 VILAS(0.759)PET(0.224)S(0.012)S(0.004)AK;VILAS(0.945)PET(0.038)S(0.013)S(0.004)AK 131.79 0.0019749000000000004 13469800.0 256874.0 248247.0 274913.0 260130.0 275775.0 190285.0 247607.0 251544.0 190363.0 233113.0 True False 242597.97142809548 267286.7466600854 257225.39688264232 224699.84525072074 241129.67904021943 216495.03151475292 259121.2161239627 252275.9513946488 228440.91918662845 226382.4219896883 1.0716290129590795 1.1806868409255746 1.1362427993387176 0.9925675468785107 1.0651431189794536 0.9563243895527112 1.1446172094393692 1.1143795935098704 1.0090930081003988 1.0 17.788402415412094 -5.736877320483108 24.616942773316435 1.0469516253078008 1.1346363714038226 0.31614013762542403 0.05942881438740452 241.94820674486743 242486.36553175715 0.016304220793484897 0.02822217754867113 1.8328320877099856e-06 5.736877320483108 0.08768474609602173 VILHLK ddPTM_A459_Selumetinib_30min_R1 1 VILHLK 6 0 P07900;P07900-2;G3V2J8;Q14568;P08238;Q58FF7;Q58FF6 P07900;P08238;Q58FF6 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB3P;HSP90AB4P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4 0 105.82 0.036548 16134000.0 14528.0 16633.0 12718.0 13059.0 13312.0 12263.0 14705.0 14021.0 8851.6 12873.0 False True 14866.47413343295 14685.600627528085 10990.96545497341 10778.490797790215 12107.931950424492 12139.645353913136 13595.790010936578 13649.117533373366 15020.518704714827 14525.374943638493 1.0234829869189603 1.0110307434067143 0.7566734420020594 0.7420456160073681 0.8335710435982419 0.8357543540884494 0.9360026893413148 0.9396740246867851 1.0340881913890412 1.0 13.82628778396041 -7.7720119888903625 1.7151427116107496 1.0113337794567712 0.8626992248258053 0.29252595896642897 0.08869533823809862 0.5404805998548228 3.030869859454148 0.07642691415557189 0.030067477798408328 1.690394266921266e-08 7.7720119888903625 -0.14863455463096586 VINAAHSFYNGTTTLPISDEDRT(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 VINAAHSFYNGTTTLPISDEDRTPR 25 1 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 1 VINAAHS(0.009)FY(0.122)NGT(0.007)T(0.007)T(0.01)LPIS(0.231)DEDRT(0.614)PR;VINAAHSFYNGTTTLPIS(0.252)DEDRT(0.748)PR 95.713 1.0387e-05 107093000.0 2961.0 2946.2 2834.1 3363.6 3247.8 2565.5 3009.1 2568.7 1625.96 2664.6 True False 3029.9855388969563 2601.257534348778 2449.2447865969593 2776.2104025918647 2954.0370634456626 2539.693399287626 2782.1211643596907 2500.5697316864826 2759.1353645802014 3006.6273654019387 1.0077688953954873 0.8651745687816657 0.8146153443493102 0.9233636447730293 0.9825085401132688 0.844698424724179 0.9253295557588211 0.8316859483357346 0.9176845113332986 1.0 11.553930359291776 -12.374705285283488 1.6097886559708428 3.402483363805835 0.8978193926622278 0.19226262836974517 0.06020724146959229 4057237.334695709 84957.55867579006 35730896.11891465 0.016694491228397796 4.2198276620372186e-13 12.374705285283488 -2.504663971143607 VINAAHSFYNGTTTLPISDEDRT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VINAAHSFYNGTTTLPISDEDRTPR 25 1 P49915-2;P49915 P49915-2 GMPS GMP synthase [glutamine-hydrolyzing] 1 VINAAHSFY(0.002)NGT(0.003)T(0.004)T(0.009)LPIS(0.243)DEDRT(0.739)PR 50.255 0.020701 2089600.0 8692.1 9142.5 8373.1 11945.0 11776.0 9492.5 8877.9 9183.6 6189.0 11694.0 True False 8209.02787923321 9843.700352229132 7834.383861941979 10318.070393725664 10296.59360122427 10800.00571066449 9290.739941225114 9210.322755573172 7426.972935108407 11356.363835339129 0.7228570692397219 0.8668003680541797 0.6898672828324389 0.9085716646042576 0.9066804965496941 0.951009131730762 0.8181086900644964 0.8110274458548227 0.6539921618218054 1.0 13.47121335554818 -5.774425637786616 24.99981558541403 0.8597914345035402 0.7705374303909147 0.18742513483455048 0.09852593243704127 443.5713549927039 853917.3777817094 0.02828538033004092 0.04224618747435205 1.6810257352440951e-06 5.774425637786616 -0.08925400411262552 VIPAKS(ph)PPPPTHSTQLGAPSR ddPTM_A459_Selumetinib_30min_R1 2 VIPAKSPPPPTHSTQLGAPSR 21 1 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 VIPAKS(1)PPPPTHSTQLGAPSR;VIPAKS(0.981)PPPPTHS(0.007)T(0.011)QLGAPS(0.001)R 105.2 8.1668e-05 74383000.0 4338.799999999999 4201.0 3492.1 5491.6 8096.200000000001 4287.1 6695.799999999999 4094.0 948.6600000000001 2408.8 True False 4439.885598164847 3709.1449670080865 3017.8920007322395 4532.595150099149 7363.900139500211 4243.975666375358 6190.730415180495 3985.4138208138215 1609.80673261498 2717.992943698937 1.6335162342704883 1.3646632069472129 1.1103384236992049 1.667625797413111 2.7093154000166844 1.561437337876124 2.2776845059632436 1.4663076407365658 0.5922777453661017 1.0 11.408325995328184 -8.102901371134397 4.77211497192849 0.8181123384855697 1.7534600990328166 0.43082401383554614 0.4364994485816502 0.23171506351875604 8.219295946222312 0.33467819317926695 0.12047038923849597 7.89039289164985e-09 8.102901371134397 0.9353477605472469 VIPAKS(ph)PPPPTHSTQLGAPSR ddPTM_A459_Selumetinib_30min_R2 3 VIPAKSPPPPTHSTQLGAPSR 21 1 Q14814-4;Q14814;Q14814-6;Q14814-3;Q14814-5;Q14814-2 Q14814-4 MEF2D Myocyte-specific enhancer factor 2D 1 VIPAKS(0.96)PPPPT(0.004)HS(0.026)T(0.009)QLGAPSR;VIPAKS(0.954)PPPPT(0.029)HS(0.011)T(0.005)QLGAPS(0.001)R;VIPAKS(0.993)PPPPTHS(0.003)T(0.003)QLGAPSR 94.325 0.00024821 175412000.0 133624.0 109804.0 242656.0 359720.0 364515.0 211908.0 153867.0 187892.0 204062.0 289730.0 True False 126197.71301925414 118225.61372449218 227043.77714387653 310725.51544838795 318721.3668945537 241096.40349070262 161022.12038167636 188438.73461280487 244880.10196866916 281364.7420910551 0.4485199960783079 0.42018631348711094 0.8069375553472893 1.1043512884348214 1.1327693886798698 0.8568820730661383 0.5722896166200045 0.6697311582551535 0.8703297369413159 1.0 18.102082029744388 -5.302666092979044 4.74047372930975 0.8737740574749695 0.4305156473086645 0.5381776115042616 0.16462296699049772 0.1659125397468221 8.943061760120903 0.05035882222367005 0.11538448646952443 4.981199169538849e-06 5.302666092979044 -0.443258410166305 VIPEDAS(ph)ESEEK ddPTM_A459_Selumetinib_30min_R2 2 VIPEDASESEEK 12 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 VIPEDAS(0.948)ES(0.052)EEK;VIPEDAS(0.777)ES(0.223)EEK 137.09 0.0013528 6349300.0 54483.0 45727.0 54580.0 56278.0 56869.0 49617.0 60028.0 62116.0 45540.0 49099.0 True False 51455.05297272954 49234.113864520834 51068.38222221079 48612.83931503495 49724.60780468946 56451.29137171875 62819.420943225465 62296.74727614263 54649.2724939145 47681.38429547766 1.0791434379058034 1.0325646914825508 1.0710339680103282 1.0195349827468334 1.0428515979433421 1.1839272748856176 1.3174831618549205 1.3065213646083502 1.1461343520409852 1.0 15.541138500568277 -6.827252793559426 4.480548331385242 1.221709986311079 1.0472822588971125 0.3859806767692373 0.08609425709975319 0.18124423894986133 7.113565653179192 0.029862811052880127 0.026699156220784705 1.4884944046388958e-07 6.827252793559426 -0.1744277274139665 VIPEDAS(ph)ESEEKLDQK ddPTM_A459_Selumetinib_30min_R1 2 VIPEDASESEEKLDQK 16 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 VIPEDAS(0.817)ES(0.183)EEKLDQK;VIPEDAS(0.971)ES(0.029)EEKLDQK 103.73 0.0023369 81160000.0 12734.0 18744.6 12935.5 13003.1 9975.5 14178.5 15418.8 15903.8 9629.7 16548.5 True False 13030.677423949295 16549.973517871877 11178.930149615388 10732.352683417254 9073.217786317568 14035.877163047986 14255.747502252905 15481.97956117705 16340.897574539333 18672.661171040287 0.6978479020525885 0.886321096188447 0.5986790017350585 0.5747628891837989 0.4859091965096736 0.7516806005571632 0.7634555873783198 0.8291255016820145 0.8751241949317153 1.0 14.18863993028818 -7.976164825298049 1.0391450865264067 0.9770872954101979 0.6604520097313906 0.5451746915668936 0.10208231445099154 0.4439377225199403 0.8835390508223183 0.10377013281981565 0.03811334268653698 1.0564164974171427e-08 7.976164825298049 -0.3166352856788073 VIPEDAS(ph)ESEEKLDQK ddPTM_A459_Selumetinib_30min_R2 1 VIPEDASESEEKLDQK 16 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 VIPEDAS(0.964)ES(0.036)EEKLDQK 150.12 0.0011359000000000002 4755400.0 98270.0 77184.0 82579.0 92578.0 77723.0 74434.0 102990.0 100110.0 65979.0 80060.0 True False 92808.54680597874 83103.76461432355 77265.9570452172 79968.71669404235 67958.74188756404 84686.60785542277 107779.2390708133 100401.30352589724 79176.64360729016 77748.4597791388 1.1937027057464722 1.0688798832851178 0.9937940541164129 1.0285569247443702 0.8740847353197151 1.0892383990112895 1.3862556168570206 1.2913606753253855 1.0183692877287656 1.0 16.246526474844032 -7.010554517752831 24.869456297381323 1.2039151111924993 1.0265804421984304 0.19436186531539945 0.1307502580894402 636.0526034451176 1498720.950100674 0.048315215486160246 0.03997162548498615 9.75990256960403e-08 7.010554517752831 -0.1773346689940689 VIQAEGS(ph)NSSMLAEIEVLR ddPTM_A459_Selumetinib_30min_R1 1 VIQAEGSNSSMLAEIEVLR 19 0 Q86V48-2;Q86V48-3;Q86V48;E5RFK8 Q86V48-2 LUZP1 Leucine zipper protein 1 1 VIQAEGS(0.781)NS(0.159)S(0.06)MLAEIEVLR 134.58 0.00020352 1859100.0 613.61 802.2 606.27 770.1 801.98 726.45 777.12 682.17 442.87 763.86 True False 627.9059191227838 708.2780510673374 523.9418640027302 635.616491567367 729.4410506010692 719.1425725638262 718.5012127370986 664.0766355995515 751.5180440549788 861.908871626482 0.7285061562690284 0.8217551464933497 0.6078854519898553 0.7374520816428244 0.8463087857821479 0.8343603323246391 0.8336162167367379 0.7704719808097493 0.8719228549496328 1.0 9.75139153310023 -11.170421322907432 0.12914692156690463 1.316970979412057 0.6437635182216704 0.5998083089176074 0.062186134707497315 35.04537359159233 0.7261882574655807 4.117683112245014 0.6696085086614348 6.754274038138719e-12 11.170421322907432 -0.6732074611903865 VIQLMPS(ph)PIMHPLILNPR ddPTM_A459_Selumetinib_30min_R2 2 VIQLMPSPIMHPLILNPR 18 0 P41212 P41212 ETV6 Transcription factor ETV6 1 VIQLMPS(1)PIMHPLILNPR;VIQLMPS(1)PIMHPLILNPR 82.03399999999998 0.0065704 21753000.0 42125.0 31807.0 37903.0 43446.0 53151.0 42264.0 38153.0 47853.0 39696.0 57297.0 True False 39783.86113973595 34246.49462437538 35464.3622456661 37528.579851469665 46473.6962040312 48085.48236560697 39927.19009873526 47992.24430750941 47636.30919891155 55642.68673451563 0.7149881408414753 0.6154716214149305 0.6373589114212787 0.6744566456779373 0.8352166103295507 0.8641833309565755 0.7175640221910435 0.8625076739462946 0.8561108744837503 1.0 15.763904462351595 -6.959239121215801 0.20285881188952845 1.0502267063411814 0.5055355338134515 0.732311036572799 0.06072791072457263 2.5801177919883367 0.2971336191725219 0.21959711450014469 0.4556076876337097 1.0984008967277655e-07 6.959239121215801 -0.5446911725277299 VIQPMGMS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 VIQPMGMSPR 10 0 H0YE35;Q9NPQ8-2;Q9NPQ8-4;Q9NPQ8;Q9NPQ8-3 H0YE35 RIC8A Synembryn-A 1 VIQPMGMS(1)PR;VIQPMGMS(1)PR 106.79 0.011689 39407000.0 6931.0 7537.5 7762.4 8249.0 7061.1 6322.0 6484.5 6267.2 3607.9 5132.5 True False 7092.478814621684 6655.005995911317 6708.308715811098 6808.467002907691 6422.424751738462 6258.406419916725 5995.368944299102 6100.973497265356 6122.342789409894 5791.306369783623 1.2246768452152663 1.1491372707605458 1.1583411906529366 1.175635783738043 1.1089768597371612 1.0806553859022578 1.0352360178318631 1.0534710318724345 1.057160923371878 1.0 12.499673104486833 -6.526096234429169 0.5343441209912805 1.0169109429425447 1.208826393018236 0.8912996772044779 0.02225032944793568 0.3373906136688066 0.2041991373564823 0.01928732320584403 0.030542274371045838 2.9778564991626975e-07 6.526096234429169 0.19191545007569122 VIQPMGMS(ph)PR ddPTM_A459_Selumetinib_30min_R2 4 VIQPMGMSPR 10 0 H0YE35;Q9NPQ8-2;Q9NPQ8-4;Q9NPQ8;Q9NPQ8-3 H0YE35 RIC8A Synembryn-A 1 VIQPMGMS(1)PR;VIQPMGMS(1)PR;VIQPMGMS(1)PR;VIQPMGMS(1)PR 128.68 0.0030775 67509000.0 188984.0 182535.0 206347.0 234189.0 245599.0 194648.0 168012.0 187293.0 166741.0 197231.0 True False 178481.02584289268 196534.84755746767 193070.85867362656 202292.05420144156 214744.6579370823 221458.99516138266 175824.89090946194 187837.9916219748 200093.8591328021 191536.42856232048 0.9318385394495338 1.0260964404143145 1.008011165932369 1.0561544648182761 1.1211687486759758 1.1562238934058762 0.9179710211222486 0.9806906865283733 1.0446778225672997 1.0 17.547259280728603 -4.281055107160242 1.5058591543198228 1.039406387144708 0.6820937851663914 0.1864886165885863 0.06430660974345007 8.41694436238589 6.3166850951658065 0.01973327657657187 6.510070180142888 5.2353400170387554e-05 4.281055107160242 -0.3573126019783165 VIS(ph)DCECVPQK ddPTM_A459_Selumetinib_30min_R2 2 VISDCECVPQK 11 0 Q7Z4H7;Q5VY60;Q7Z4H7-3 Q7Z4H7 HAUS6 HAUS augmin-like complex subunit 6 1 VIS(1)DCECVPQK;VIS(1)DCECVPQK 98.182 0.018501 17645200.0 93639.0 76652.0 94640.0 94598.0 101346.0 72362.0 76491.0 92396.0 74242.0 85858.0 True False 88434.91924661676 82530.96192497325 88550.96543624092 81713.58920934785 88614.00943526458 82329.20866316603 80047.98306404102 92664.85706301889 89092.47449480038 83379.05645412586 1.0606370833096745 0.989828446552172 1.0620288739410306 0.9800253527011986 1.0627849870670931 0.9874087350516201 0.960049039510089 1.1113685019211264 1.0685234192331976 1.0 16.34739742575841 -7.768874867452261 24.999998564838535 1.067459449941742 1.0150139971010534 0.18118617074797694 0.04323837692695855 252.9198761685492 850363.3559583696 0.022013072094444718 0.010900773157243544 1.702649019160443e-08 7.768874867452261 -0.05244545284068858 VIS(ph)DGEQGGQQGHR ddPTM_A459_Selumetinib_30min_R2 1 VISDGEQGGQQGHR 14 0 Q9HBR0 Q9HBR0 SLC38A10 Putative sodium-coupled neutral amino acid transporter 10 1 VIS(1)DGEQGGQQGHR 82.925 0.028844 28288000.0 34943.0 37374.0 47528.0 49662.0 46518.0 45655.0 34995.0 42713.0 40225.0 40824.0 True False 33001.007947911996 40240.465623649055 44470.10022457372 42897.94992827158 40673.99296380356 51943.56183517383 36622.336841276985 42837.28775848221 48271.123980406504 39645.30504650971 0.8324064579449448 1.0150121326205244 1.1216990302484449 1.0820436336142714 1.0259472821835285 1.3102071424153876 0.9237496545508643 1.0805135112020916 1.2175747903510252 1.0 15.274862405953675 -4.802057752469411 2.475163504404987 1.09658617629084 0.7800774434013557 0.37469760710546074 0.10288553218438205 0.5235681597537323 4.205232016864799 0.02593960895876488 0.35101490475751956 1.5774014929402727e-05 4.802057752469411 -0.31650873288948433 VISDSESDIGGS(ph)DVEFKPDTK ddPTM_A459_Selumetinib_30min_R2 1 VISDSESDIGGSDVEFKPDTK 21 1 P52701-2;P52701;P52701-3;A0A087WWJ1;A0A494C0M1 P52701-2 MSH6 DNA mismatch repair protein Msh6 1 VIS(0.059)DS(0.071)ES(0.299)DIGGS(0.57)DVEFKPDT(0.002)K 76.61399999999998 0.035196 0.0 6974.9 7325.8 6483.3 9207.7 9564.6 4184.5 7805.4 9228.0 6731.8 7829.7 True False 6587.262980736955 7887.665303840329 6066.17153648331 7953.59537583154 8363.009439391113 4760.87689189103 8168.366566106683 9254.851952222361 8078.34810220759 7603.636216996297 0.8663306334951352 1.0373543760824784 0.7977987588259003 1.0460252369850342 1.0998697466216756 0.6261315975702667 1.0742710899093322 1.2171613275678717 1.062432219488641 1.0 12.892473795016523 -7.498977722726713 24.995467560231987 1.1130213704978982 0.9209159072694645 0.27545157311825563 0.13872567702731664 933.1042893321973 975834.9287992704 0.05717959777525243 0.03830326321166088 3.1697300511824435e-08 7.498977722726713 -0.1921054632284337 VISFIENTST(ph)PVDR ddPTM_A459_Selumetinib_30min_R1 1 VISFIENTSTPVDR 14 0 E9PGE5;Q9NUY8-2;Q9NUY8 E9PGE5 TBC1D23 TBC1 domain family member 23 1 VISFIENT(0.053)S(0.199)T(0.748)PVDR 153.14 0.00086328 4240700.0 1162.5 1077.2 1244.2 1232.1 1328.9 1143.5 935.8 1120.1 775.31 902.88 True False 1189.5839881687648 951.080923223306 1075.2444739013918 1016.9368643814473 1208.7012296363512 1131.9974282149278 865.2118525830978 1090.3913094024326 1315.6444435980434 1018.7734427959547 1.1676629348562837 0.9335548840114332 1.055430411446981 0.9981972651255346 1.1864278934471952 1.1111375509634778 0.849268165264087 1.070298128708506 1.2914004118396984 1.0 9.992617541960495 VISGTTLGYLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 VISGTTLGYLSPK 13 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3;E5RJ67;E5RJN7 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 VISGTTLGYLS(1)PK;VISGTTLGYLS(1)PK 151.3 0.00046924 38111000.0 5345.3 6048.5 6131.9 5790.799999999999 4842.2 5317.1 5827.6 6526.1 4566.6 5458.5 True False 5469.83508985677 5340.338808128638 5299.221660115697 4779.545486778741 4404.223864959847 5263.61480154053 5388.019440172325 6353.006628239635 7749.186668732282 6159.151645292533 0.8880825485174388 0.8670575292963086 0.8603817482178597 0.7760071129977403 0.7150698860168534 0.8546006178567682 0.8747989577899761 1.0314742994021369 1.2581581222561746 1.0 12.588515934053692 -7.819477033181104 2.7448350639107972 1.134171528750729 0.8256565757965671 0.7254503133130923 0.0757593837600008 0.13610455984269473 2.038886648144309 0.049635404392302795 0.02119848933915566 1.515384939764611e-08 7.819477033181104 -0.30851495295416187 VISGTTLGYLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 VISGTTLGYLSPK 13 0 H0YBY0;E7EPX0;E7EVJ4;Q9NUL3-4;Q9NUL3-6;Q9NUL3-8;Q9NUL3-3;Q9NUL3-7;Q9NUL3-2;Q9NUL3;E5RJ67;E5RJN7 H0YBY0 STAU2 Double-stranded RNA-binding protein Staufen homolog 2 1 VISGTTLGYLS(1)PK;VISGTTLGYLS(1)PK 146.59 0.00059626 16521100.0 164772.0 142723.0 148596.0 180533.0 163749.0 146871.0 172907.0 177383.0 146722.0 178633.0 True False 155614.63187457735 153669.39517322351 139035.49513909195 155944.09396320407 143177.38668536636 167101.1470878068 180947.51810872077 177899.1551626635 176070.49975520675 173475.4011457274 0.8970414874201894 0.8858281586801697 0.8014709533503005 0.898940673624405 0.8253469122408352 0.9632555738979619 1.0430730634640035 1.0255007568088568 1.0149594616432063 1.0 17.404371577234002 -6.942758728719049 4.157047406865542 1.021445203895982 0.8622547259170266 0.8582786707519916 0.030652388600015297 0.0743736052356268 2.6503566011315436 0.011191429670822742 0.009623134683708354 1.1408834266486894e-07 6.942758728719049 -0.15919047797895547 VISHDRDS(ph)PPPPPPPPPPPQPQPSLK ddPTM_A459_Selumetinib_30min_R1 4 VISHDRDSPPPPPPPPPPPQPQPSLK 26 1 Q69YN4-3;Q69YN4;Q69YN4-4;Q69YN4-2 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 VIS(0.029)HDRDS(0.971)PPPPPPPPPPPQPQPSLK;VIS(0.103)HDRDS(0.897)PPPPPPPPPPPQPQPSLK;VIS(0.388)HDRDS(0.612)PPPPPPPPPPPQPQPSLK;VIS(0.173)HDRDS(0.827)PPPPPPPPPPPQPQPSLK 236.65 4.4601999999999994e-46 42894000.0 5890.23 8185.4 6756.74 7876.299999999999 7434.0 5810.860000000001 6531.5599999999995 6436.68 3264.8099999999995 5863.539999999999 True False 6027.460898607572 7227.049562710777 5839.211820116133 6500.852061462216 6761.5960125793035 5752.408024238742 6038.879170610874 6265.958337116731 5540.144117712046 6616.182474716229 0.9110179354395893 1.092329238247128 0.8825651109882031 0.9825684352427175 1.021978465439666 0.8694451893099374 0.912743745156437 0.9470655262399607 0.8373626542018349 1.0 12.691783309337215 -6.7624734068384456 24.998964642036817 0.9099787909613167 0.979380017175295 0.18795672908040728 0.06710573621804063 44.42204705571875 1073947.5117132154 0.021812239049801025 0.020340677853001317 1.7279317837454343e-07 6.7624734068384456 0.06940122621397826 VISHDRDS(ph)PPPPPPPPPPPQPQPSLK ddPTM_A459_Selumetinib_30min_R2 1 VISHDRDSPPPPPPPPPPPQPQPSLK 26 1 Q69YN4-3;Q69YN4;Q69YN4-4;Q69YN4-2 Q69YN4-3 KIAA1429 Protein virilizer homolog 1 VIS(0.075)HDRDS(0.925)PPPPPPPPPPPQPQPSLK 181.22 2.9481e-22 0.0 8698.5 8118.1 10284.0 9379.9 10630.0 7715.0 6718.2 7527.5 6870.7 10027.0 True False 8215.072192854432 8740.732166194295 9622.338636372588 8102.341438769975 9294.564366594264 8777.671220202961 7030.609611860747 7549.403778755293 8245.031983397863 9737.494456725279 0.8436535937826004 0.8976366769746851 0.9881739783406852 0.8320766162977405 0.9545129301896443 0.9014301634996662 0.7220142350894998 0.7752922286431945 0.8467303391072398 1.0 13.249334886551955 -7.050548863849397 24.921424028530275 0.8164890117226354 0.9060996378284418 0.12588157065922767 0.07983987797164052 523.443301100397 258064.51723562603 0.02920935997357982 0.022625768437133226 8.901252815576553e-08 7.050548863849397 0.08961062610580639 VISRPPPSVS(ph)PPK ddPTM_A459_Selumetinib_30min_R1 2 VISRPPPSVSPPK 13 1 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;A0A0C4DGG3 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 VISRPPPS(0.006)VS(0.994)PPK;VISRPPPS(0.005)VS(0.995)PPK 82.837 0.017730000000000003 98094000.0 7199.8 8909.5 9356.0 10092.1 7268.2 8311.8 7182.9 7883.2 4679.200000000001 8123.7 True False 7367.541331627929 7866.371598085817 8085.506588829313 8329.704187179617 6610.792593304936 8228.190838510573 6641.088070014031 7674.111927757575 7940.2606447536655 9166.456026538966 0.803750250947283 0.8581693486894924 0.8820755333817061 0.9087158835501132 0.7211939460752547 0.8976414455802871 0.724498983116984 0.8371950845058639 0.8662301571910466 1.0 13.162148345506402 -8.727197473932767 2.5908331709589603 0.9999024480520194 0.8301475302850863 0.408344160633325 0.0616413627146074 0.9401281997570109 10.208418425462213 0.05824616037783348 0.015672570447376397 1.874142140864242e-09 8.727197473932767 -0.1697549177669332 VISRPPPSVS(ph)PPK ddPTM_A459_Selumetinib_30min_R2 1 VISRPPPSVSPPK 13 1 Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5;A0A0C4DGG3 Q8NHM5-4 KDM2B Lysine-specific demethylase 2B 1 VISRPPPS(0.285)VS(0.715)PPK 62.813 0.046465 43098000.0 97281.0 95255.0 86540.0 80214.0 76908.0 55323.0 83403.0 73747.0 58671.0 78774.0 True False 91874.51146669788 102560.75220690038 80972.11061762771 69288.71482313184 67246.12947375653 62943.24107780798 87281.40475990917 73961.591560527 70406.83940470922 76499.58994056833 1.2009804436608633 1.340670613876214 1.0584646359612389 0.9057396892841055 0.879039084078742 0.822791875442834 1.1409395112799574 0.9668233727525458 0.9203557752323573 1.0 16.223164394122136 -5.448612130754123 3.934287726461557 0.9476849005923562 1.2677024605495735 0.6869517864648422 0.08605038015423754 0.12811021365737194 3.7436007519314076 0.024193659090935064 0.05258720257195971 3.5594907546432924e-06 5.448612130754123 0.32001755995721726 VIVGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VIVGSPR 7 0 A0A1C7CYW6;A0A1B0GWB1;A0A1B0GTQ2;P0DI83 A0A1C7CYW6 RAB34 Ras-related protein Rab-34, isoform NARR 1 VIVGS(1)PR 84.916 0.036904 4040400.0 29751.0 27802.0 27846.0 30809.0 37363.0 25228.0 22053.0 32397.0 30068.0 28799.0 True False 28097.558522689247 29934.324002480116 26054.41867643242 26612.7610515106 32669.12591054199 28702.928003017543 23078.508197190495 32491.269906387915 36082.44017011466 27967.49804121185 1.0046504153244507 1.0703254169668672 0.9315963350757944 0.9515603080509755 1.1681104209751618 1.0262958796214803 0.8251903035152761 1.161751038956363 1.2901561704570406 1.0 14.771463576338661 -7.952391136975944 24.99301147829861 1.1720373878923391 1.002428994863193 0.2949641929631013 0.10733227582023516 126.23169849471375 66267.03619182421 0.05799877471654636 0.027861694451767692 1.115857824334451e-08 7.952391136975944 -0.1696083930291461 VIY(ph)T(ph)AFT(ph)LRK ddPTM_A459_Selumetinib_30min_R1 1 VIYTAFTLRK 10 1 F8VZA0;Q9H0K6 F8VZA0 PUS7L Pseudouridylate synthase 7 homolog-like protein 3 VIY(1)T(1)AFT(1)LRK 61.999 0.043991 0.0 937.95 943.56 1321.1 1461.3 887.55 1143.0 1087.5 1123.5 513.53 1047.8 True False 959.8024100670052 833.087556550857 1141.7018762828563 1206.1113869983028 807.2712592096797 1131.5024577609645 1005.4689994487264 1093.7011303576774 871.4229032527677 1182.295336436294 0.8118127345068171 0.7046357461427292 0.965665549966732 1.0201439097559124 0.6828000029527124 0.9570387557913991 0.8504380999077927 0.9250659261283566 0.7370602559250836 1.0 10.207374749272565 VIYINS(ph)PLPQK ddPTM_A459_Selumetinib_30min_R2 2 VIYINSPLPQK 11 0 Q659A1;H0YK97;H0YNU9 Q659A1 ICE2 Little elongation complex subunit 2 1 VIYINS(1)PLPQK;VIY(0.001)INS(0.999)PLPQK 98.368 0.018317 5915500.0 77885.0 70165.0 80166.0 88719.0 85276.0 74275.0 96251.0 101030.0 86602.0 72242.0 True False 73556.46349835806 75546.4298839656 75008.20683814138 76635.3191511886 74562.8665028874 84505.70704868117 100726.86221773834 101323.98057358323 103924.81986205484 70156.1857527422 1.0484672550129759 1.0768320579773354 1.06916027479743 1.0923529882494096 1.0628124334706004 1.2045367937548985 1.4357516894196494 1.4442629610835533 1.4813350917954191 1.0 16.098282693107627 -7.019162738155133 3.3232347197346637 1.3759862420976627 1.0724906092664603 0.4900704893035296 0.12761298105481514 0.1801296211163245 4.121866631422548 0.04763061518311431 0.03826278004999941 9.56835460209323e-08 7.019162738155133 -0.3034956328312024 VIYINS(ph)PLPQKK ddPTM_A459_Selumetinib_30min_R2 1 VIYINSPLPQKK 12 1 Q659A1;H0YK97;H0YNU9 Q659A1 ICE2 Little elongation complex subunit 2 1 VIY(0.001)INS(0.999)PLPQKK 70.47 0.032425 3955400.0 37717.0 37994.0 46011.0 43757.0 34471.0 33851.0 30715.0 28602.0 26257.0 38329.0 True False 35620.84013311384 40908.01763003483 43050.70235298904 37797.22111496472 30140.44480535003 38513.66798121717 32143.308360617866 28685.227084684007 31509.133681877756 37222.34217929819 0.9569747105523345 1.0990178273302342 1.1565823060143805 1.015444458946118 0.8097406837045609 1.034692223173349 0.8635487849148539 0.7706454082472479 0.8465113111394176 1.0 15.183881217970276 -6.074243017881666 5.35367771405194 0.8831418277231232 1.07587026224029 0.4768625353924997 0.08817784313174352 0.18478882299548696 9.566881787835614 0.026787694888836214 0.035361566458589 8.428629854876086e-07 6.074243017881666 0.1927284345171668 VKADRDESSPYAAMLAAQDVAQR ddPTM_A459_Selumetinib_30min_R1 2 VKADRDESSPYAAMLAAQDVAQR 23 2 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 ; 126.25 1.5027e-05 44348000.0 6144.2 5474.1 10875.4 11207.5 9109.4 7377.3 7050.8 6428.400000000001 4230.9800000000005 5076.5 False True 6287.347905467977 4833.189827159954 9398.580414296095 9250.32051583076 8285.456378395196 7303.091060052467 6518.952479368351 6257.897949613968 7179.664041447232 5728.118224297434 1.0976288650605033 0.8437657251309186 1.6407797545849103 1.6148969266369029 1.4464534518945662 1.274954666451251 1.1380617899463685 1.092487568267939 1.2534070981622998 1.0 12.483845553773941 -7.1777267464230565 3.670629381491612 1.1272940820496862 1.3365284764282934 0.15699930437987453 0.22717849704061716 0.5389550420912533 13.79032920664919 0.10401388811754972 0.07745447988397933 6.641608220561443e-08 7.1777267464230565 0.20923439437860725 VKAPVHFVEPLS(ph)PTGVAGHR ddPTM_A459_Selumetinib_30min_R1 2 VKAPVHFVEPLSPTGVAGHR 20 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 VKAPVHFVEPLS(0.987)PT(0.013)GVAGHR;VKAPVHFVEPLS(0.975)PT(0.025)GVAGHR 128.51 8.115e-05 62815000.0 12891.3 14847.1 18979.3 20254.6 17400.0 14837.6 16853.4 16260.9 9483.0 10976.8 True False 13191.642207896766 13108.794629770477 16402.015305832425 16717.51433593091 15826.1730722195 14688.347215462894 15582.134469249808 15829.608109152776 16091.95838908339 12385.779203086387 1.0650635694046255 1.058374641984892 1.3242618842862337 1.3497345675082846 1.277769675425492 1.185904170793125 1.2580665466220267 1.2780470125939454 1.2992285850754925 1.0 13.596397012531545 -5.250158679464659 24.674579586275872 1.2595914029023274 1.0617190614226615 0.37910764100541405 0.09348391999754618 558.5978423320266 1221829.5666144304 0.02260798040992178 0.0585890340176631 5.621358984012573e-06 5.250158679464659 -0.19787234147966593 VKAPVHFVEPLS(ph)PTGVAGHR ddPTM_A459_Selumetinib_30min_R2 1 VKAPVHFVEPLSPTGVAGHR 20 1 Q5T5Y3-2;Q5T5Y3;Q5T5Y3-3 Q5T5Y3-2 CAMSAP1 Calmodulin-regulated spectrin-associated protein 1 1 VKAPVHFVEPLS(0.938)PT(0.062)GVAGHR 76.156 0.0024807 3183200.0 16513.0 16739.0 19134.0 22354.0 20014.0 15000.0 12458.0 13751.0 11296.0 19839.0 True False 15595.273566776485 18022.827475631777 17902.939271524032 19309.34663719912 17499.66239256986 17066.11384355727 13037.321685058678 13791.013133399401 13555.51563661086 19266.196522087645 0.8094630172020385 0.9354636995926823 0.9292409765985356 1.002239680004406 0.9083091399232562 0.8858060709591485 0.6766941087781441 0.7158139966852698 0.7035906449449013 1.0 14.23378416652682 -7.109707690140408 5.238359061989938 0.7511379716138245 0.9211302095733085 0.3267099124698807 0.09520346504804131 0.22167649172449727 8.855883078861375 0.03537883852518466 0.027350225201689476 7.767697598430124e-08 7.109707690140408 0.16999223795948404 VKAQT(ph)PPGPSLSGSK ddPTM_A459_Selumetinib_30min_R1 2 VKAQTPPGPSLSGSK 15 1 Q9UQ35;Q9UQ35-2;I3L4D8 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 VKAQT(0.98)PPGPS(0.019)LS(0.001)GSK;VKAQT(0.935)PPGPS(0.026)LS(0.008)GS(0.031)K 142.39 0.0039548000000000005 101712000.0 11106.3 15477.8 18023.0 19113.0 16405.2 14827.4 16252.8 15668.099999999999 8014.8 13830.4 True False 11365.055180902158 13665.651980565994 15575.575593252534 15775.273345444857 14921.352556573296 14678.249818202043 15026.838210795657 15252.53109083855 13600.53022216869 15605.666559504221 0.7282646426903546 0.8756852473080227 0.9980717923110204 1.0108682820624115 0.9561496460070037 0.9405717956508971 0.9629090916109543 0.9773713306433167 0.8715122914045376 1.0 13.929782359463013 -4.870853747113632 2.7529435731375256 0.9638705566791318 0.7068208121426345 0.7854868672114751 0.03797263547430451 0.15908949049364365 1.8940229650354403 0.009950330817715437 0.08579552864990656 1.346313661930132e-05 4.870853747113632 -0.2570497445364973 VKAS(ph)PITNDGEDEFVPSDGLDKDEYTFSPGK ddPTM_A459_Selumetinib_30min_R1 1 VKASPITNDGEDEFVPSDGLDKDEYTFSPGK 31 2 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 VKAS(0.524)PIT(0.459)NDGEDEFVPS(0.016)DGLDKDEYTFSPGK 49.972 0.006278 50958000.0 3857.3 4560.7 5737.9 5461.6 3893.8 4059.7 4122.9 4054.0 2387.1 3825.4 True False 3947.1675850007523 4026.7311237880945 4958.724696028614 4507.834086929402 3541.606477506226 4018.8631039126785 3811.9063336341674 3946.4747507521306 4050.7343531140955 4316.427352551442 0.9144524539878055 0.932885183717477 1.1488030009580747 1.0443437868275065 0.8204948649055291 0.931062375354731 0.8831160638857847 0.9142919429466055 0.9384460856777087 1.0 12.0756219921398 -6.239194280624363 24.93827581324358 0.9095352105146894 1.014510110049361 0.2875265594274804 0.07330123937539487 997.3413031509257 1118087.78671827 0.02252057300223458 0.029051575228205166 5.765085059616266e-07 6.239194280624363 0.10497489953467154 VKEDPDGEHAR ddPTM_A459_Selumetinib_30min_R1 2 VKEDPDGEHAR 11 1 A0A087X0X3;P52272-2;P52272;M0R2T0;M0R019;M0QYQ7;M0R0N3 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 ; 89.9 0.022766 20060100.0 18342.5 22713.0 19213.1 17103.7 18548.2 21641.0 15666.8 19544.0 19288.0 18767.9 False True 18769.844561708018 20053.751401012763 16604.06655000388 14116.859871212535 16870.51858495069 21423.311188455864 14485.040662586958 19025.629632141023 32730.327260217302 21176.942779827004 0.8863340075503264 0.9469615897586414 0.7840634374202866 0.6666146297878346 0.7966456140695349 1.0116338043309796 0.6840005572657682 0.8984124776624837 1.5455643243932247 1.0 14.370206708504861 -8.106479352587135 6.9757991226976905 1.2677138878152407 0.8257566966449812 0.5549347955768682 0.15815502895786177 0.17449611505672216 9.922561703885012 0.10287272180689527 0.038410083841303344 7.825654092395496e-09 8.106479352587135 -0.44195719117025956 VKEDPDGEHAR ddPTM_A459_Selumetinib_30min_R2 1 VKEDPDGEHAR 11 1 A0A087X0X3;P52272-2;P52272;M0R2T0;M0R019;M0QYQ7;M0R0N3 A0A087X0X3 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 90.653 0.021921 7764600.0 59825.0 47538.0 42921.0 50687.0 54560.0 44386.0 64599.0 84108.0 59527.0 79349.0 False True 56500.1659984499 51184.011741238035 40159.50958885139 43783.34316004794 47705.68502741138 50499.76860400888 67602.98150049015 84352.7403551711 71434.0633233475 77057.98819653878 0.7332162092571698 0.6642272000495475 0.5211595907023074 0.5681869483586461 0.61908811979021 0.6553476126992527 0.8773001097312151 1.094665748864697 0.9270169776707992 1.0 16.23365690065249 -7.359169937603832 2.6957470663758856 1.0079753660960777 0.6164148043777502 0.8742631841526807 0.06590370289155555 0.09416885727353742 1.3313498607974505 0.033072883079126834 0.020667022820007923 4.373509380896784e-08 7.359169937603832 -0.39156056171832754 VKEEASS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 1 VKEEASSPLK 10 1 Q9P2R6;A0A590UJ84;B1AKN3;Q9P2R6-2;D6RA28 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 VKEEAS(0.001)S(0.999)PLK 164.81 0.0017527 16411000.0 69456.0 54306.0 53820.0 55514.0 59824.0 41860.0 58198.0 51294.0 38975.0 47543.0 True False 65595.91357439762 58471.09557868804 50357.27979478538 47952.89743300849 52308.37428665427 47625.83503275386 60904.3223171492 51443.2570478212 46771.08905248831 46170.31005845116 1.4207379913921703 1.2664219821063407 1.0906853285376155 1.0386089539424923 1.1329439681135425 1.0315251288644156 1.3191230953408135 1.1142064452825753 1.0130122365060266 1.0 15.49467780044199 -4.988456405458289 2.49145624594746 1.101873524414308 1.4316384234380923 0.5926568209616809 0.08744672185564922 0.2550595936859619 2.7026794905187073 0.02363096016559291 0.14883639829692033 1.026936510527092e-05 4.988456405458289 0.32976489902378425 VKEEPPS(ph)PPQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VKEEPPSPPQSPR 13 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 2 VKEEPPS(1)PPQS(1)PR 178.02 2.6436e-09 0.0 42133.0 35922.0 42983.0 43144.0 48465.0 36097.0 41651.0 46129.0 37394.0 42009.0 True False 39791.416531762465 38677.10189256492 40217.52057635189 37267.71277244873 42376.393417402745 41069.03409405914 43587.85402989077 46263.227752932944 44873.84487565745 40796.09101750994 0.9753732659014741 0.9480590156533493 0.9858179931770982 0.9135118547620945 1.0387366132508755 1.0066904222865876 1.0684321204005203 1.1340112888040297 1.099954523986068 1.0 15.316143302828944 -6.871353752663525 1.3532904890287467 1.0875700808577236 0.9594713938017801 0.5896400703702206 0.04164046888585815 0.2677001127281507 1.0180883496231106 0.020193089357458085 0.016534746665790856 1.3447645357709379e-07 6.871353752663525 -0.1280986870559434 VKEEPPS(ph)PPQSPR ddPTM_A459_Selumetinib_30min_R1 1 VKEEPPSPPQSPR 13 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 1 VKEEPPS(1)PPQSPR 134.88 0.0055875 17389000.0 2110.6 2795.0 2777.1 2983.4 2511.4 2464.7 2275.4 2003.1 1167.0 1840.4 True False 2159.7728734873076 2467.7601006397517 2399.98507351837 2462.405195353958 2284.2443134236837 2439.9073557685465 2103.7647460649514 1949.9712810142062 1980.3137656923266 2076.6332670140832 1.0400357674096052 1.188346608830001 1.1557096342625883 1.185767961280213 1.0999748244947058 1.1749341564179034 1.0130651278113634 0.9390060883585863 0.953617471677967 1.0 11.020030743706752 -7.406862145308236 3.8473138629557813 0.9615101691144878 1.1436087712257328 0.7682773318994823 0.044680669845570814 0.10554109189461769 2.7472290097982968 0.01951683547625881 0.012491641306183616 3.918662443973161e-08 7.406862145308236 0.18209860211124496 VKEEPPS(ph)PPQSPR ddPTM_A459_Selumetinib_30min_R2 1 VKEEPPSPPQSPR 13 1 E9PMQ6;Q00613-2;Q00613 E9PMQ6 HSF1 Heat shock factor protein 1 1 VKEEPPS(0.928)PPQS(0.072)PR 69.289 0.035379 33192000.0 183720.0 135530.0 159420.0 178360.0 180610.0 123390.0 130050.0 140290.0 109780.0 146130.0 True False 173509.57788943112 145924.71520236417 149163.0907633723 154067.0603118384 157920.15712611369 140385.85247710228 136097.58268918633 140698.2206737401 131739.0675094851 141910.8472086629 1.2226660702990948 1.0282844340136972 1.0511042228086052 1.0856609155838612 1.1128124469154288 0.989253853658429 0.959035798645266 0.9914550116585538 0.9283227469974764 1.0 17.114625343018098 -6.832288547627358 5.2538661644143785 0.97010865479816 1.0925329455087824 0.5998026142826138 0.051577901997618136 0.15147925176101923 7.671485487966951 0.01810046674208615 0.01609337434739573 1.471334614852265e-07 6.832288547627358 0.12242429071062244 VKEGMNIVEAMER ddPTM_A459_Selumetinib_30min_R1 4 VKEGMNIVEAMER 13 1 P62937;P62937-2 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 ;;; 147.7 0.001596 124320000.0 11994.5 13712.8 16799.0 18647.6 15405.400000000001 14203.7 13445.4 13147.7 7972.200000000001 10700.4 False True 12273.9485127658 12107.299001092231 14517.788070301798 15391.146718804877 14011.984290044284 14060.823673927745 12431.202653046352 12798.980286251563 13528.241133549584 12073.90057072239 1.0165686259276063 1.0027661674182433 1.2024107690190453 1.2747451934568992 1.160518442898353 1.1645634806719696 1.029592928998469 1.0600534774393782 1.12045324990946 1.0 13.559604205183573 -7.259554912660643 24.91579611801363 1.057529369973762 1.1411435738436944 0.20563281884198925 0.08077748780495167 315.7711903374662 4175056.4676654274 0.03596313917171365 0.026404686889889242 5.501043603271468e-08 7.259554912660643 0.08361420386993235 VKELQAEQEDR ddPTM_A459_Selumetinib_30min_R2 1 VKELQAEQEDR 11 1 Q00341;Q00341-2;A0A024R4E5;H0Y394 Q00341 HDLBP Vigilin 0 93.766 0.030541 0.0 26623.0 28169.0 24544.0 29221.0 32805.0 23373.0 23151.0 22830.0 19949.0 29764.0 False True 25143.400240313105 30329.471722389106 22964.865761486657 25241.04939096338 28683.742619579007 26592.418591030957 24227.56737283622 22896.431520290032 23939.357421631546 28904.635983840748 0.8698743085493145 1.0492943671508237 0.7945045830822868 0.8732526299613145 0.9923578569062336 0.9200053100788937 0.8381896726317791 0.7921369960545559 0.8282186094651024 1.0 14.819013283157842 -7.25737854269764 22.996729780930295 0.8473143995083134 0.9185125799907389 0.07048654712027647 0.08316051130417425 233.15205054206447 1320363.226520658 0.03211182325857712 0.023901501298488188 5.5286800458407163e-08 7.25737854269764 0.07119818048242543 VKEPS(ph)VQEATSTSDILK ddPTM_A459_Selumetinib_30min_R2 2 VKEPSVQEATSTSDILK 17 1 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 VKEPS(0.852)VQEAT(0.043)S(0.017)T(0.064)S(0.025)DILK;VKEPS(0.344)VQEAT(0.264)S(0.264)T(0.094)S(0.034)DILK 66.809 0.022163 27699000.0 168426.0 149696.0 152760.0 151486.0 134201.0 112865.0 135463.0 143827.0 89909.0 122322.0 True False 159065.55718269822 161177.20185149516 142931.58791251233 130853.34547207427 117341.47060783797 128411.12926353962 141762.29791484206 144245.5127581582 107893.31226735523 118790.24602927614 1.339045607696579 1.3568218539742114 1.2032266342582243 1.1015495787408771 0.9878039193463652 1.080990515264127 1.1933833176833761 1.2142875158504896 0.9082674367116359 1.0 16.8580568544904 -5.5021599187308885 2.362696500316819 1.0797461347314359 1.351687107347607 0.6203832640338807 0.0872210269750694 0.21054632691870112 2.309455697516986 0.025726472842754085 0.06248454071557355 3.1465894431779015e-06 5.5021599187308885 0.27194097261617123 VKESSIIAPAPAEDVDT(ph)PPR ddPTM_A459_Selumetinib_30min_R1 5 VKESSIIAPAPAEDVDTPPR 20 1 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR 126.5 0.00029439 109540000.0 31105.6 30453.2 45783.7 43614.1 39005.2 30394.4 30927.7 32648.7 20939.0 27361.3 True False 31830.299959038573 26887.725186691398 39566.5250118624 35997.71617305323 35477.18654692736 30088.659931907136 28594.798688965875 31782.750418076263 35531.95367594827 30873.389376631403 1.0309946721668166 0.8709029273942684 1.2815737374727953 1.165978757107262 1.1491186184365183 0.9745823357730122 0.9261956418238215 1.0294545257195884 1.1508925451133984 1.0 14.914076254742113 -6.765586948092319 24.947318647875075 1.0124390818224207 1.1007867535739784 0.12147045078140273 0.11201433255016714 246.9446540318869 1485343.8188626466 0.041852648880197206 0.03824212399490133 1.7155882057456504e-07 6.765586948092319 0.08834767175155767 VKESSIIAPAPAEDVDT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 4 VKESSIIAPAPAEDVDTPPR 20 1 Q15910-5;Q15910-3;Q15910-4;Q15910;Q15910-2 Q15910-5 EZH2 Histone-lysine N-methyltransferase EZH2 1 VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR;VKESSIIAPAPAEDVDT(1)PPR 141.21 8.4232e-05 96984000.0 471117.0 472810.0 475227.0 500880.0 503641.0 371145.0 379510.0 370451.0 336717.0 454763.0 True False 444934.20317077666 509073.0066762328 444651.4122080346 432659.27993380476 440369.11497233366 422266.8548311374 397157.9669847981 371528.95107853593 404069.80865905585 441632.8105738272 1.0074754241938226 1.1527064893905379 1.006835093684016 0.9796810145777828 0.9971385830689264 0.95614919163835 0.899294521321363 0.8412621122868947 0.9149451738742768 1.0 18.752487833812253 -6.203935025056861 0.8511665610571126 0.9041335294017423 1.078620439241809 0.5200920425247654 0.05470598909295305 0.46899875544390573 0.7216400917005085 0.02784212442257684 0.049846869963629796 6.252662320690392e-07 6.203935025056861 0.17448690984006676 VKGDVDVSLPK ddPTM_A459_Selumetinib_30min_R2 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 106.49 0.012719 0.0 48064.0 43565.0 40615.0 48470.0 44911.0 34583.0 40248.0 43998.0 38298.0 43002.0 False True 45392.79529543665 46906.2954164465 38001.87511826843 41868.30238458627 39268.87867056586 39346.49433678275 42119.61174989901 44126.026895738985 45958.67013552784 41760.42052738611 1.0869812784971469 1.1232237325217014 0.9099974243158576 1.0025833517919058 0.9403372421696203 0.9421958361501575 1.0086012357628762 1.0566470916355244 1.1005317847646807 1.0 15.349848619467778 -10.316688180729528 10.875467541950698 1.0000013649883654 1.0146140796638348 0.0031372949071919454 0.06933158167156515 0.0 0.0 0.07214056494393153 0.01749665700915061 4.8229395577324476e-11 10.316688180729528 0.014612714675469318 VKPAS(ph)PVAQPK ddPTM_A459_Selumetinib_30min_R1 2 VKPASPVAQPK 11 1 Q96EV2;H0Y3K4 Q96EV2 RBM33 RNA-binding protein 33 1 VKPAS(1)PVAQPK;VKPAS(1)PVAQPK 148.85 0.0030454 349460000.0 11276.0 13716.0 14133.199999999999 14806.7 12155.0 11604.900000000001 13262.2 11963.2 6987.5 10786.7 True False 11538.70886072343 12110.124343604588 12213.989068110552 12220.987801182357 11055.58239613955 11488.165242406138 12261.821576541526 11645.89707404981 11857.277153192046 12171.278016355585 0.9480277128842083 0.994975575065427 1.0035091673772936 1.0040841877705835 0.9083337330133467 0.9438750168198039 1.0074391169164216 0.9568343651669302 0.9742014879011399 1.0 13.57119304234667 -10.831048079060093 2.2828967620044383 1.0007400393024088 0.9718497598680746 0.07261057217480937 0.030754082894208876 1348798.6833477258 1280003.9365644148 6768.254153648799 0.008493717418707466 1.475543172563609e-11 10.831048079060093 -0.0288902794343342 VKPAS(ph)PVAQPK ddPTM_A459_Selumetinib_30min_R2 2 VKPASPVAQPK 11 1 Q96EV2;H0Y3K4 Q96EV2 RBM33 RNA-binding protein 33 1 VKPAS(1)PVAQPK;VKPAS(1)PVAQPK 118.52 0.0029062 599340000.0 1020130.0 890940.0 976810.0 959940.0 888540.0 634510.0 796090.0 863430.0 549270.0 769120.0 True False 963435.258503949 959272.2331763769 913963.1080703143 829194.5160111354 776913.6615516151 721907.9929917014 833109.7624224081 865942.4383514682 659139.3478860862 746913.5071862512 1.2898886540871 1.2843150163264776 1.2236532065317267 1.1101613614337362 1.0401654998560403 0.9665215397044433 1.1154032621004173 1.1593610639250842 0.882484171921291 1.0 19.51058166259439 -5.77535184701982 1.8503188893817784 1.0363171660933739 1.2889104042697266 0.6923625427930337 0.07175735215228347 0.20452717958656808 1.428392251551389 0.022630376584736246 0.04555666297035954 1.677444472913073e-06 5.77535184701982 0.2525932381763527 VKPPGGHS(ph)PQVNHLK ddPTM_A459_Selumetinib_30min_R1 1 VKPPGGHSPQVNHLK 15 1 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 VKPPGGHS(1)PQVNHLK 84.40299999999998 0.0093273 28161000.0 4492.0 5526.8 5433.5 5983.5 4806.2 4746.5 5016.8 4380.4 2911.1 4535.4 True False 4596.654860089541 4879.7196866603845 4695.660544079097 4938.59404920574 4371.480058603527 4698.754519477181 4638.37873695115 4264.217562455512 4939.924081668321 5117.562768537095 0.8982117206944469 0.953524149554359 0.9175579775881083 0.9650285248220776 0.8542113221316009 0.9181625574512232 0.9063647964355259 0.83325163858703 0.9652884205034279 1.0 12.321241177133409 -6.234469778320641 24.977102222737216 0.9044807411184053 0.9338606524428745 0.025085619295211914 0.04848459512914989 2010.47320253563 1861939.7625458324 0.01343229862806442 0.01733659314119173 5.828143302621064e-07 6.234469778320641 0.029379911324469266 VKPPGGHS(ph)PQVNHLK ddPTM_A459_Selumetinib_30min_R2 1 VKPPGGHSPQVNHLK 15 1 Q92610 Q92610 ZNF592 Zinc finger protein 592 1 VKPPGGHS(1)PQVNHLK 80.488 0.012457 14751000.0 123400.0 109250.0 125600.0 120720.0 126900.0 91408.0 99786.0 113750.0 89675.0 109720.0 True False 116541.92200933925 117629.12370588293 117519.03274294002 104277.7277463846 110957.68749960592 103998.62228079236 104426.24672220794 114080.99366767386 107612.50572884882 106552.09851320383 1.0937552956303107 1.1039587708477316 1.1029255583209108 0.978654847735942 1.0413468063780662 0.976035420530971 0.9800487102491702 1.0706592855469388 1.009952006862761 1.0 16.70119948130477 -5.749950950169796 24.999505756725835 1.0099242280230232 1.1005878020063107 0.6937059192020577 0.028030170258471414 125.89028386633622 273942.1835922632 0.007759449250086536 0.013294494897071312 1.7784802627611082e-06 5.749950950169796 0.0906635739832875 VKPPPQIS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 VKPPPQISPSK 11 1 K7ESE9;Q9H6U6-6;Q9H6U6-2;Q9H6U6;Q9H6U6-8;Q9H6U6-3;Q9H6U6-7 K7ESE9;Q9H6U6-8 BCAS3 Breast carcinoma-amplified sequence 3 1 VKPPPQIS(0.5)PS(0.5)K 113.99 0.026258 0.0 3449.2 4124.3 4478.7 4772.0 3676.6 3810.8 3579.5 3877.6 2188.3 3990.4 True False 3529.559649025119 3641.42503866495 3870.517139738119 3938.6597815341834 3344.0521791564515 3772.466811929557 3309.4954331280173 3774.7534517800864 3713.3852728916177 4502.606709787543 0.7838925041693598 0.8087370879516084 0.8596169706149509 0.8747510132236334 0.742692487862046 0.8378406232392351 0.7350176567573624 0.838348471247714 0.824718993293295 1.0 12.136544752433176 -9.079428969611191 1.6547453190448873 0.9999792584729862 0.8102049638307046 0.6283352583038344 0.04360460919990055 2.8352542259000115 7.739699206909167 0.042102969876509695 0.01193369551198864 8.328581317209304e-10 9.079428969611191 -0.18977429464228157 VKPPPS(ph)PTTEGPSLQPDLAPEEAAGTQRPK ddPTM_A459_Selumetinib_30min_R1 2 VKPPPSPTTEGPSLQPDLAPEEAAGTQRPK 30 2 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5 Q9Y2D5-5 AKAP2 A-kinase anchor protein 2 1 VKPPPS(0.916)PT(0.049)T(0.035)EGPSLQPDLAPEEAAGTQRPK;VKPPPS(0.458)PT(0.458)T(0.084)EGPSLQPDLAPEEAAGTQRPK 167.65 6.337999999999999e-28 193883000.0 12766.3 15183.300000000001 16512.7 17327.9 15379.4 13745.6 13722.5 14013.6 8795.5 11637.3 True False 13063.729951104428 13405.63217747534 14270.366037768472 14301.907549967764 13988.335985453607 13607.331744006227 12687.400776951867 13641.913805411963 14925.321102096694 13131.060811901212 0.9948723974581124 1.020910067321086 1.086764142074086 1.0891661956972558 1.0652860561559057 1.036270560233287 0.9662129327321949 1.0389041678222786 1.1366424476969348 1.0 13.680695850711597 -10.650631839263285 4.416386451842742 0.9999934457662829 1.0473117948120245 0.08750931776338589 0.04672031923013667 3.220425988127225e-06 6.361133952058309e-07 0.04762606142957779 0.011549393327706967 2.2354664726409244e-11 10.650631839263285 0.047318349045741614 VKPPPS(ph)PTTEGPSLQPDLAPEEAAGTQRPK ddPTM_A459_Selumetinib_30min_R2 3 VKPPPSPTTEGPSLQPDLAPEEAAGTQRPK 30 2 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5 Q9Y2D5-5 AKAP2 A-kinase anchor protein 2 1 VKPPPS(0.792)PT(0.17)T(0.038)EGPSLQPDLAPEEAAGTQRPK;VKPPPS(0.453)PT(0.453)T(0.093)EGPSLQPDLAPEEAAGTQRPK;VKPPPS(0.745)PT(0.121)T(0.121)EGPS(0.012)LQPDLAPEEAAGTQRPK 104.26 1.0906e-09 109867800.0 136095.0 121461.0 142495.0 145423.0 141979.0 116352.0 106643.0 124946.0 106719.0 145775.0 True False 128531.38473145073 130776.66814132905 133327.02683682524 125616.13653133257 124142.32871163549 132378.43186170515 111602.11080909555 125309.57217407611 128065.78197799878 141566.09698106357 0.9079249020239895 0.9237852206861523 0.9418005417968087 0.8873320605012899 0.8769213205633638 0.9350998203998843 0.7883392506330373 0.8851665394917118 0.9046359595202328 1.0 17.111116276767007 -5.7789366142434355 24.352456812778023 0.8882504790175538 0.9244317179056742 0.04125495668151291 0.05064269714501486 415.8695087846898 578801.21427162 0.013841115282066604 0.020586087911405995 1.6636554449908464e-06 5.7789366142434355 0.036181238888120415 VKPPPSPTT(ph)EGPSLQPDLAPEEAAGTQRPK ddPTM_A459_Selumetinib_30min_R2 1 VKPPPSPTTEGPSLQPDLAPEEAAGTQRPK 30 2 Q9Y2D5-5;Q9Y2D5-7;Q9Y2D5-6;Q9Y2D5-4;Q9Y2D5 Q9Y2D5-5 AKAP2 A-kinase anchor protein 2 1 VKPPPS(0.015)PT(0.179)T(0.538)EGPS(0.268)LQPDLAPEEAAGTQRPK 83.435 2.1548e-05 5464300.0 18425.0 14761.0 16917.0 18530.0 20586.0 13604.0 16449.0 13557.0 15859.0 19371.0 True False 17401.012261118918 15893.121235904217 15828.578637836938 16006.182033967056 17999.802638824982 15477.827515183542 17213.911093075145 13596.448625517834 19031.243137483332 18811.708898097677 0.9250096498611344 0.8448526033438355 0.8414216232868452 0.8508627323903397 0.9568403772527653 0.822776261265064 0.9150636545739814 0.7227652043293509 1.0116700848697406 1.0 14.19934329203764 -8.319630840932415 24.997386640145994 1.0058355878026497 0.8623530283761923 0.4747214286367262 0.06134144422753608 254.7683596223383 109438.66397866073 0.05553340126643903 0.014338677844966818 4.790371105154787e-09 8.319630840932415 -0.14348255942645738 VKVDGPRS(ph)PSYGR ddPTM_A459_Selumetinib_30min_R2 1 VKVDGPRSPSYGR 13 2 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 VKVDGPRS(0.685)PS(0.312)Y(0.003)GR 55.011 0.044011 123270000.0 145080.0 318360.0 275370.0 316840.0 221420.0 98901.0 43145.0 31379.0 25498.0 261810.0 True False 137017.03440125549 342777.1883112564 257652.99400018717 273685.84542051447 193603.24008008465 112523.71501611054 45151.3279901956 31470.30769492691 30598.312473645845 254250.86503592803 0.5389048897902223 1.3481849442786311 1.0133809926812969 1.0764401740849145 0.7614654135108909 0.4425696447491334 0.17758573991012888 0.12377660028995323 0.1203469355721642 1.0 17.955893156999117 -6.685527787204829 2.248635541323434 0.2844954536596495 1.0192860465691234 0.47699309562786674 0.3043615073956077 0.22471871386544917 2.3275701238057525 0.10990613198414659 0.1064371911609192 2.0628716756000257e-07 6.685527787204829 0.7347905929094738 VKVEPADSVESSPPS(ph)ITHSPQNELK ddPTM_A459_Selumetinib_30min_R2 1 VKVEPADSVESSPPSITHSPQNELK 25 1 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 VKVEPADSVES(0.015)S(0.015)PPS(0.772)IT(0.187)HS(0.01)PQNELK 59.429 0.0034744 7212000.0 19122.0 19717.0 23973.0 26011.0 24976.0 17682.0 15884.0 18563.0 15922.0 22771.0 True False 18059.27579143099 21229.230499852536 22430.603279828865 22468.25692852225 21838.291591727022 20117.534998785322 16622.637473548897 18617.01525672993 19106.844897850395 22113.542063836758 0.8166613805829015 0.960010406228391 1.0143378756364234 1.016040617267985 0.9875528546573339 0.9097382473016119 0.7516949308963318 0.8418830055803294 0.8640336696262085 1.0 14.432642508667868 -7.004987742727546 10.557457456757986 0.8482833609083973 0.9636214113370621 0.2376620042053974 0.07754962557162501 0.19977247304804946 356.0975324832675 0.028299931280949802 0.0237384752638938 9.885809953927622e-08 7.004987742727546 0.11533805042866485 VKVEPADSVESSPPSIT(ph)HSPQNELK ddPTM_A459_Selumetinib_30min_R2 1 VKVEPADSVESSPPSITHSPQNELK 25 1 Q2TB10 Q2TB10 ZNF800 Zinc finger protein 800 1 VKVEPADSVES(0.001)S(0.001)PPS(0.373)IT(0.492)HS(0.133)PQNELK 57.692 0.005810899999999999 7237900.0 41482.0 31204.0 49425.0 52382.0 62553.0 34137.0 37884.0 41660.0 34072.0 53725.0 True False 39176.59650560298 33597.24646332599 46245.049309871174 45247.48123600982 54694.532909084744 38839.06188516766 39645.68106572189 41781.223702815754 40887.352051222115 52173.819655686166 0.7508861103929798 0.6439483765046593 0.8863650316396023 0.867244942666921 1.0483137571685124 0.7444166852548006 0.7598769138881919 0.8008082210301086 0.7836756503750825 1.0 15.67103843677164 -12.15771590918975 1.9194545172239967 4.11061795515383 0.8119876639659873 0.2376092364031731 0.1022809487559374 3403714.292584714 103036.30470658447 46370021.074979946 0.02760752805291398 6.954791117990432e-13 12.15771590918975 -3.298630291187843 VLAET(ph)PDSFEK ddPTM_A459_Selumetinib_30min_R1 2 VLAETPDSFEK 11 0 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 VLAET(0.907)PDS(0.093)FEK;VLAET(0.955)PDS(0.045)FEK 166.24 0.0014180999999999998 18894300.0 7620.4 9129.1 9028.0 8905.4 7979.4 7132.799999999999 8603.8 7750.799999999999 4386.2 6704.0 True False 7797.940493282802 8060.260727996548 7802.047187254276 7350.239065061716 7257.66467887749 7061.050508064224 7954.808439040879 7545.223605853387 7443.061044626975 7564.523702489902 1.0308567730068807 1.0655344665445985 1.0313996616450805 0.9716724217074431 0.959434455402472 0.9334428426392588 1.0515940926224494 0.9974486038519303 0.9839431188743653 1.0 12.88503353119022 -5.633689819944365 4.739534917342268 0.9849231502698758 1.0482291341501762 0.4399226159757499 0.029909924081706868 0.19856691553943573 7.343699555904563 0.008763850997012816 0.015598859833773963 2.3243963246366523e-06 5.633689819944365 0.0633059838803004 VLAET(ph)PDSFEK ddPTM_A459_Selumetinib_30min_R2 2 VLAETPDSFEK 11 0 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 VLAET(0.567)PDS(0.433)FEK;VLAET(1)PDSFEK 114.24 0.015522 6903900.0 59551.0 53172.0 59288.0 60438.0 60937.0 46873.0 53587.0 53697.0 42102.0 59131.0 True False 56241.393821540994 57250.12142507273 55473.47462789364 52206.2401386347 53281.54927630804 53329.33027927065 56078.901680626055 53853.249379983106 50523.57642816842 57423.73438921137 0.9794102459506271 0.996976634034946 0.9660373923420046 0.9091404572330126 0.9278663229244535 0.9286984005221721 0.976580542472731 0.937822138403122 0.8798378748014803 1.0 15.809359534713302 -5.547060494598667 6.426777039313267 0.9354605339160376 0.9867740340482892 0.30277667495543426 0.03148634112794833 0.18074274761317288 26.29873770637728 0.008374539763077532 0.015042805494750806 2.8375237509893314e-06 5.547060494598667 0.051313500132251666 VLAGDKNFITAEELR ddPTM_A459_Selumetinib_30min_R1 2 VLAGDKNFITAEELR 15 1 O43707;O43707-2;F5GXS2;O43707-3;H7C144 O43707 ACTN4 Alpha-actinin-4 0 ; 155.86 0.00047443 40528000.0 3842.4 4655.1 5108.3 5626.9 5203.5 4788.799999999999 4605.4 4043.2 2876.2 4123.1 False True 3931.9204439911077 4110.078727902722 4414.620917883366 4644.267544994697 4732.844343752539 4740.629019882507 4258.01097017119 3935.961201835476 4880.701330663469 4652.340047395007 0.8451489796393354 0.8834433179930786 0.9489033202453145 0.998264851167784 1.0173040438870347 1.0189773257302928 0.9152407018389349 0.8460175227387658 1.049085251925282 1.0 12.183740834345354 -5.204643067618856 2.442144972071516 0.9722936501580614 0.8493326291823161 0.3974976700194346 0.05561169811384422 0.355328546086832 3.9481836225984224 0.016138594335092016 0.060877543251097156 6.242476733861966e-06 5.204643067618856 -0.12296102097574524 VLAGETLS(ph)VNDPPDVLDR ddPTM_A459_Selumetinib_30min_R1 2 VLAGETLSVNDPPDVLDR 18 0 Q12906-7;Q12906-4;Q12906-6;Q12906;Q12906-5;Q12906-2;Q12906-3;K7EKJ9;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 VLAGET(0.002)LS(0.998)VNDPPDVLDR;VLAGET(0.015)LS(0.985)VNDPPDVLDR 186.75 1.8945e-10 12605700.0 3412.6000000000004 3232.7 3761.3 4429.7 3697.5 3182.5 3538.3 3570.7 2375.46 2649.6000000000004 True False 3492.106940236325 2854.213981158544 3250.5361193419913 3656.1360507673867 3363.0617778466444 3150.486939478803 3271.4031822983256 3475.9934367317805 4030.9821232660584 2989.7019692895637 1.1680451684172877 0.9546817744635544 1.0872441978269858 1.2229098713930293 1.1248819489006796 1.0537795980471747 1.094223844350513 1.1626554995907412 1.3482889480866656 1.0 11.545785960102831 -7.884916031699933 4.8224159535560265 1.1983836806766657 1.0987844854165072 0.0765889012570089 0.10290734505934039 0.4089832387340922 15.27651827917912 0.057918195295331036 0.02674625263089563 1.3034187624922664e-08 7.884916031699933 -0.09959919526015848 VLAPILPDNFST(ph)PTGSR ddPTM_A459_Selumetinib_30min_R1 2 VLAPILPDNFSTPTGSR 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 VLAPILPDNFS(0.076)T(0.897)PT(0.027)GSR;VLAPILPDNFS(0.206)T(0.786)PT(0.008)GSR 254.89 8.9566e-31 109303000.0 5729.4 6418.0 6522.5 6506.799999999999 6104.8 4882.3 6518.8 5089.4 3348.6000000000004 4749.0 True False 5862.883872528273 5666.577576352744 5636.780325527918 5370.5095277633345 5552.621917889977 4833.18849477372 6027.081667684009 4954.412579298942 5682.32962793258 5358.580409177285 1.0941113923544565 1.057477380883932 1.0519167195614305 1.002226171425107 1.0362113645584883 0.9019531528343288 1.124753424873839 0.9245755780418724 1.0604169750258539 1.0 12.387635138349205 -5.361817512023589 1.2689625788833208 1.0044896444909348 1.092319694103014 0.18492577073527616 0.06005881453849779 1.0381740772948382 2.6976249535932557 0.018023381009673007 0.09070062140979464 4.346928411662138e-06 5.361817512023589 0.08783004961207919 VLAPILPDNFST(ph)PTGSR ddPTM_A459_Selumetinib_30min_R2 2 VLAPILPDNFSTPTGSR 17 0 Q9NQS7-2;Q9NQS7 Q9NQS7-2 INCENP Inner centromere protein 1 VLAPILPDNFS(0.078)T(0.915)PT(0.007)GSR;VLAPILPDNFS(0.027)T(0.97)PT(0.003)GSR 286.84 3.3436999999999985e-75 43767000.0 189043.0 186321.0 199130.0 213917.0 215257.0 197925.0 181726.0 185827.0 174615.0 211050.0 True False 178536.7468590884 200611.22158355868 186318.1925963511 184781.1355725923 188214.4912380038 225187.37216573843 190176.61908323778 186367.72580468422 209542.8791507439 204956.43812624653 0.871096065541086 0.978799316662542 0.9090624051613597 0.901562972414524 0.9183146085026603 1.0987084583653346 0.9278879981613222 0.9093040819234365 1.022377638226091 1.0 17.64495778330155 VLAVNQENEHLMEDYEK ddPTM_A459_Selumetinib_30min_R1 2 VLAVNQENEHLMEDYEK 17 0 O43707;O43707-2;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 ; 236.31 3.1964e-22 23915000.0 9906.6 11554.3 13603.4 12752.7 10752.2 10392.7 11854.7 11137.5 6753.9 9700.3 False True 10137.40450511199 10201.517184551658 11756.132998127474 10525.68034282711 9779.665408455094 10288.158873816601 10960.490434726276 10842.097320301396 11460.875014661013 10945.42799392345 0.9261770769256307 0.9320345618476694 1.0740679126164918 0.9616508690816504 0.8934931931290809 0.9399503500025999 1.0013761399564447 0.9905594670505878 1.0470924500187406 1.0 13.418040748196999 -7.391403325563957 4.51183987712378 1.0110652066204757 0.9566567825872442 0.25468715722614643 0.04635238921566612 0.39162265413245106 12.589102876226708 0.02200085441854995 0.014399867363290967 4.0606604394604414e-08 7.391403325563957 -0.05440842403323154 VLAVNQENEHLMEDYEK ddPTM_A459_Selumetinib_30min_R2 2 VLAVNQENEHLMEDYEK 17 0 O43707;O43707-2;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 ; 199.65 5.4175e-21 12521000.0 109433.0 102177.0 117496.0 115928.0 127087.0 83705.0 93232.0 89813.0 81677.0 108244.0 False True 103351.15195500835 110013.6473491625 109936.43527997218 100138.40641304565 111121.1948878048 95234.6039516641 97567.47273570314 90074.34096065756 98014.68224605733 105118.71446831286 0.9831850824827455 1.0465657604890628 1.0458312379106538 0.9526220608722487 1.0571019199564256 0.9059719235852315 0.9281646301440837 0.8568820634484614 0.9324189583349882 1.0 16.681660012120552 -6.772260046993694 24.992288968244576 0.9159599429854762 1.016718736388359 0.5157066416397582 0.04435608623462925 156.89733044414345 362380.4104159919 0.014911336095355962 0.013275581697284523 1.6894290318454923e-07 6.772260046993694 0.10075879340288274 VLCPINYPLS(ph)PTR ddPTM_A459_Selumetinib_30min_R2 1 VLCPINYPLSPTR 13 0 Q96LD4-2;Q96LD4 Q96LD4-2 TRIM47 Tripartite motif-containing protein 47 1 VLCPINYPLS(0.79)PT(0.21)R 149.32 0.0005225 3642000.0 13815.0 11263.0 12926.0 16922.0 16515.0 16237.0 12885.0 15115.0 10737.0 14467.0 True False 13047.217605826756 12126.83588374697 12094.355232764687 14617.194407921777 14440.238054026737 18473.499365189306 13484.178031143134 15158.982147577042 12884.700016845849 14049.300120219865 0.9286738481050096 0.8631629889017696 0.8608510836321586 1.0404215357948396 1.027826150090155 1.314905312514614 0.9597757835450178 1.0789848617270346 0.9171061836953776 1.0 13.778210642505435 -5.803429321343991 5.883749825206751 1.0594033396677889 0.8819103174193889 0.3504726143763519 0.10177396246847992 0.19289714322713059 16.37838743592231 0.029004563362948377 0.044515214954973875 1.5724276742122614e-06 5.803429321343991 -0.17749302224840002 VLDDVSIRS(ph)PETK ddPTM_A459_Selumetinib_30min_R1 1 VLDDVSIRSPETK 13 1 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 VLDDVS(0.024)IRS(0.976)PETK 85.976 0.014895 37985000.0 6842.6 9184.3 10791.0 11241.0 8930.6 9150.7 8888.7 7657.0 4421.8 7589.7 True False 7002.019266618141 8108.997886334764 9325.641470720078 9277.970369703638 8122.8288068254915 9058.652266170831 8218.218202666574 7453.911486558727 7503.471644505852 8563.911924938484 0.8176192525086527 0.9468801124309802 1.0889464478918103 1.0833799379330122 0.948495136103801 1.0577703677441663 0.9596336667983197 0.8703862851336214 0.8761733785065463 1.0 13.064054243147318 -7.547593807336839 7.329794480684525 0.9063959098471451 0.9964435027011467 0.137931079555782 0.08221102175250668 0.3187194288668882 66.76682174042683 0.0402265861171439 0.023455328411110702 2.83404141619696e-08 7.547593807336839 0.09004759285400155 VLDEEGS(ph)ER ddPTM_A459_Selumetinib_30min_R2 2 VLDEEGSER 9 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 VLDEEGS(1)ER;VLDEEGS(1)ER 104.79 0.014119 110323000.0 171289.0 70846.0 119609.0 215268.0 205727.0 184985.0 369160.0 462190.0 400600.0 100548.0 True False 161769.44310419538 76279.66039420552 111913.48716043276 185948.12704198717 179881.73503728482 210465.00462336268 386326.6714766624 463534.8963803262 480731.19369921304 97644.91798492217 1.656711341896718 0.7811943721022352 1.1461271049222845 1.9043297990244648 1.8422027356821709 2.155411760967034 3.9564442210532347 4.747148197225204 4.923258717606226 1.0 16.575257339291397 -7.106279404922329 2.3785358794288918 3.9949351931768953 1.425430543844672 0.4738516205668871 1.066528192255814 0.22931438544472507 2.5444865650924764 0.45442428497423804 0.3351661634762634 7.829257825756053e-08 7.106279404922329 -2.5695046493322233 VLDNYLTSPLPEEVDET(ph)SAEDEGVSQR ddPTM_A459_Selumetinib_30min_R1 1 VLDNYLTSPLPEEVDETSAEDEGVSQR 27 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 VLDNYLTSPLPEEVDET(0.493)S(0.493)AEDEGVS(0.014)QR 62.401 0.0040084000000000005 3454400.0 352.26 537.59 379.94 656.69 525.08 358.31 501.52 421.65 293.05 359.74 True False 360.46697262135814 474.6487128811895 328.3462348610313 542.011419098006 477.58660671040354 354.7057267194501 463.68994262393124 410.46647228777425 497.28444647483786 405.91613316433705 0.8880331259842323 1.169327045912279 0.8089016622753912 1.3352793220430341 1.176564732688391 0.8738399332747039 1.1423294240837778 1.0112100474744987 1.2250916035246866 1.0 8.665037870962434 -5.742458262225313 24.99998889771398 1.10403715936595 0.9768114213388678 0.17911173570222472 0.14846640269242878 509.42789907250915 670961.2660393713 0.03956886025701677 0.06839395498226139 1.8094297967466046e-06 5.742458262225313 -0.12722573802708215 VLDPFTIKPLDR ddPTM_A459_Selumetinib_30min_R1 2 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 ; 153.74 0.0012989000000000002 50957000.0 21442.7 22981.2 21049.0 23785.0 20543.0 19520.8 19481.6 19634.0 12942.7 19334.4 False True 21942.273189768923 20290.55042032996 18190.661413880738 19631.39624974656 18684.889277161223 19324.43847546829 18012.087227273867 19113.242539779807 21962.816602593015 21816.158573004283 1.005780789332944 0.9300698082309441 0.8338159696175934 0.899855773602545 0.8564701807898596 0.8857855708557558 0.8256305603481612 0.8761048594242841 1.0067224497428346 1.0 14.413109471331447 -8.263317532732831 24.678703404818126 1.003361246211931 0.8857389450014038 0.46532168888957537 0.04884223887791325 126.48543758345075 1661920.1967640999 0.041619599806765405 0.01284960224072809 5.453589781779325e-09 8.263317532732831 -0.11762230121052719 VLDPFTIKPLDR ddPTM_A459_Selumetinib_30min_R2 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 105.25 0.026491000000000004 12133000.0 45176.0 34256.0 40234.0 40971.0 35023.0 38407.0 36457.0 37322.0 28718.0 34664.0 False True 42665.29877385666 36883.32504959926 37645.38824346702 35390.6791210828 30623.097630407407 43697.21562596696 38152.32273817501 37430.60084101029 34462.40244796304 33663.160252111804 1.2674181049647626 1.0956584222446983 1.1182963204147003 1.051317786447653 0.9096917045536839 1.298072293234135 1.1333553490653507 1.1119158320455709 1.02374233999023 1.0 15.038883000841002 -2.8054776582065877 0.013551925531228299 4.989785263458022e-07 2.3542265689328947 0.1449525713822435 0.10266245399663662 13822.107291652881 18.141381783959353 1340.5615712867284 1846.7155405328708 0.0015650288283099655 2.8054776582065877 2.3542260699543682 VLDS(ph)PSRLDEEHR ddPTM_A459_Selumetinib_30min_R2 1 VLDSPSRLDEEHR 13 1 E7EVB6;O60941-6;O60941-3;O60941-4;O60941-7;O60941 E7EVB6 DTNB Dystrobrevin;Dystrobrevin beta 1 VLDS(0.5)PS(0.5)RLDEEHR 71.545 0.031646 6203700.0 22900.0 21588.0 30244.0 29060.0 32338.0 18543.0 19142.0 21685.0 19046.0 26667.0 True False 21627.309675963283 23243.730183639327 28298.13396717742 25101.977868703867 28275.411334611978 21097.12993340552 20032.140929153415 21748.09975985501 22855.732189703474 25897.05442081309 0.8351262396306248 0.8975433964782759 1.0927163185182411 0.9692985719846876 1.0918388970093618 0.8146536509746861 0.7735297074193068 0.8397904798924304 0.8825610750284655 1.0 14.660500391972727 -6.786238263558116 24.99948904659673 0.8465577727398285 0.9788405261407622 0.2748072041565587 0.09183025901555278 281.62327561297974 283899.3452327146 0.033067877992324926 0.02917531224508028 1.635918773967058e-07 6.786238263558116 0.13228275340093376 VLDSVEAGDT(ph)TPPTK ddPTM_A459_Selumetinib_30min_R2 1 VLDSVEAGDTTPPTK 15 0 Q8IZ21-3 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 VLDS(0.005)VEAGDT(0.608)T(0.386)PPT(0.001)K 125.73 0.0028166 8153900.0 61875.0 59717.0 66131.0 71337.0 71606.0 57899.0 56572.0 60396.0 49942.0 63621.0 True False 58436.23520525012 64297.10187958078 61876.203457988624 61620.777536810965 62610.21411423787 65874.06169520816 59202.71009529135 60571.74236090398 59931.79549607111 61784.09642279033 0.9458135440772542 1.0406739857388847 1.001490788739031 0.9973566193335293 1.0133710410814198 1.0661977031181307 0.958219242864143 0.980377570732925 0.9700197780017065 1.0 15.914947907571026 VLDSVEAGDTT(ph)PPTK ddPTM_A459_Selumetinib_30min_R1 3 VLDSVEAGDTTPPTK 15 0 Q8IZ21-3 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 VLDSVEAGDT(0.028)T(0.97)PPT(0.002)K;VLDSVEAGDT(0.03)T(0.97)PPTK;VLDSVEAGDT(0.154)T(0.834)PPT(0.012)K 151.3 0.0005825 23830900.0 13653.0 14877.3 15005.9 15920.8 14764.6 12336.3 13990.400000000001 13748.6 7573.900000000001 12826.900000000001 True False 13971.08833588657 13135.458799730875 12968.18120150852 13140.531150429471 13429.144536901855 12212.20802246421 12935.092864264338 13383.942466253282 12852.355124230597 14473.357559586466 0.9652969795272407 0.9075612721963446 0.8960036500251465 0.9079117334267616 0.9278527447148589 0.8437715970317767 0.8937174951293002 0.9247296220764195 0.8880009404395461 1.0 13.821112019640816 -10.559417936327039 4.352571479433066 1.0000057999094079 0.9048848887822653 0.47348453137676916 0.029682942236319787 21101492.312923163 1.7428988619882677 1288.227536976528 0.007222188869287801 2.757922536267052e-11 10.559417936327039 -0.0951209111271426 VLDSVEAGDTT(ph)PPTK ddPTM_A459_Selumetinib_30min_R2 1 VLDSVEAGDTTPPTK 15 0 Q8IZ21-3 Q8IZ21-3 PHACTR4 Phosphatase and actin regulator 4 1 VLDSVEAGDT(0.08)T(0.92)PPTK 209.11 3.4392e-06 8455100.0 56107.0 52796.0 56809.0 67288.0 63054.0 50122.0 48158.0 57676.0 42495.0 48579.0 True False 52988.797554116674 56845.283434103316 53153.97078896248 58123.25832172563 55132.59281008791 57025.85053778521 50397.44242326663 57843.827611224224 50995.187409505896 47176.39804659987 1.1232056652942313 1.2049517510419665 1.1267068489726173 1.2320410359500673 1.1686477792481968 1.2087792391749845 1.068276606736383 1.2261179319813118 1.08094703116448 1.0 15.525777651482443 -8.513713031931957 4.897469490109581 1.0001603215959636 1.1691655654985786 0.5534394293387704 0.04919292215621369 0.10372704763870744 8.72364861347825 0.04404111142322946 0.011463436125780041 3.0639873509529123e-09 8.513713031931957 0.16900524390261507 VLDTSSLT(ph)QSAPAS(ph)PTNK ddPTM_A459_Selumetinib_30min_R1 1 VLDTSSLTQSAPASPTNK 18 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 2 VLDT(0.003)S(0.016)S(0.1)LT(0.441)QS(0.441)APAS(0.999)PT(0.001)NK 142.4 0.00095909 0.0 1511.5 1482.6 1540.0 1440.2 1489.8 1478.2 1360.5 1499.8 842.15 1135.1 True False 1546.7150091329793 1309.0165027579599 1330.8764586144866 1188.6961059022485 1355.0478530455532 1463.330650098213 1257.8763896551661 1460.0204319630122 1429.0670417975946 1280.8011418103047 1.207615264104799 1.0220294626750372 1.0390968708330512 0.9280879498765332 1.0579689608414207 1.1425119812353683 0.9821012400701514 1.139927490929151 1.115760280926771 1.0 10.322830783765161 -6.527312219782765 24.790161144788943 1.081300700523049 1.0398544918848174 0.017172701747535712 0.0811020734910669 392.116340671368 2192529.731316809 0.02671098560136656 0.026797938647571316 2.9695304312797566e-07 6.527312219782765 -0.041446208638231674 VLDTSSLTQS(ph)APAS(ph)PTNK ddPTM_A459_Selumetinib_30min_R2 2 VLDTSSLTQSAPASPTNK 18 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 2 VLDTSS(0.001)LT(0.187)QS(0.819)APAS(0.976)PT(0.017)NK;VLDT(0.004)S(0.001)S(0.004)LT(0.019)QS(0.971)APAS(0.999)PT(0.001)NK 173.09 7.201000000000002e-07 12426700.0 63885.0 54105.0 69055.0 70512.0 69094.0 53429.0 56301.0 56997.0 50118.0 63054.0 True False 60334.52745191767 58254.67952500487 64612.0764813992 60908.14396001542 60413.794011802864 60788.35976982809 58919.10805831501 57162.8518336387 60143.000413921975 61233.467186033246 0.9853194702925361 0.9513536012589565 1.0551758613488504 0.9946871663329228 0.986613967624271 0.9927309780637951 0.9622043429177873 0.9335230301425261 0.9821916539725192 1.0 15.902032753813508 -7.242899131766643 6.700409176074119 0.9638969310421871 0.9948721357372765 0.1409303786663545 0.02873507112172233 0.28225294221220354 59.475808311882155 0.011434860743135131 0.008523353758108643 5.71611382395192e-08 7.242899131766643 0.03097520469508941 VLDTSSLTQS(ph)APASPTNK ddPTM_A459_Selumetinib_30min_R1 1 VLDTSSLTQSAPASPTNK 18 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 VLDTSS(0.005)LT(0.247)QS(0.684)APAS(0.016)PT(0.048)NK 91.518 0.0053387 71901000.0 926.33 1373.3 941.12 1210.6 761.37 1060.4 748.05 809.84 579.07 583.99 True False 947.9116866755886 1212.5133975701508 813.3210732021206 999.191435776463 692.5042179307914 1049.733338766166 691.6239862414898 788.360412468946 982.639496400561 658.950805044313 1.4385166228180624 1.8400666457773154 1.234266757056965 1.5163369224645982 1.0509194504804071 1.593037493437122 1.0495836425831204 1.1963873576509714 1.4912182956275175 1.0 9.364026952477172 -1.5228787455505333 0.16328010687311345 1.0511990171041175 3.2855379506863924 0.2799784479148666 0.22338786194060634 77.401779921447 0.8136982359973933 0.6080307747493624 41.79324413507267 0.029999999981335543 1.5228787455505333 2.2343389335822748 VLDTSSLTQSAPAS(ph)PTNK ddPTM_A459_Selumetinib_30min_R2 3 VLDTSSLTQSAPASPTNK 18 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 VLDTSSLTQS(0.06)APAS(0.938)PT(0.001)NK;VLDTSSLTQS(0.062)APAS(0.855)PT(0.083)NK;VLDTSSLT(0.001)QS(0.004)APAS(0.992)PT(0.002)NK 274.16 2.0853999999999998e-54 78081000.0 148598.0 136096.0 152539.0 162301.0 159385.0 117013.0 146250.0 124175.0 114168.0 150461.0 True False 140339.51804492553 146534.12558238738 142724.80681190573 140195.32381515863 139361.63138002122 133130.4786117446 153050.91478887715 124536.32869172224 137004.79012044874 146116.7999853733 0.9604612067809718 1.0028561096126924 0.9767857414492576 0.9594743645439304 0.9537687069109897 0.9111236943669128 1.0474559722372647 0.8523067074024936 0.937638862431721 1.0 17.156762538014057 -5.909014334370922 2.1997380524678474 0.9459801636827315 0.9832232195707212 0.06373736319779932 0.049236520908595593 0.7848210606533123 7.711932718355697 0.015022950491955435 0.025157631392150867 1.2330641339082854e-06 5.909014334370922 0.03724305588798971 VLDTSSLTQSAPASPT(ph)NK ddPTM_A459_Selumetinib_30min_R2 1 VLDTSSLTQSAPASPTNK 18 0 Q8N122;Q8N122-3;I3L436 Q8N122 RPTOR Regulatory-associated protein of mTOR 1 VLDTSSLTQS(0.003)APAS(0.198)PT(0.799)NK 169.49 2.2736e-07 26735000.0 117270.0 110240.0 124050.0 106910.0 128630.0 99741.0 97361.0 91439.0 87961.0 117070.0 True False 110752.60286900488 118695.0535225308 116068.75805542775 92348.67356996342 112470.34943320983 113479.41739134965 101888.47941716142 91705.07235145867 105555.65783568774 113689.88491561041 0.9741640863759709 1.0440247486452785 1.0209242285853586 0.8122857511775289 0.989273139969261 0.9981487576980398 0.8961965217291853 0.8066247267250679 0.9284524996576385 1.0 16.7947443765892 -5.6763249972316245 24.9999999996072 0.9159584050284697 1.0161390358939861 0.2924605867136766 0.06708528044631906 30.839080781666016 9053.911617136688 0.018753084205713883 0.032481297781046234 2.1070507825298095e-06 5.6763249972316245 0.10018063086551643 VLEDDPEATY(ph)TTSGGK ddPTM_A459_Selumetinib_30min_R1 2 VLEDDPEATYTTSGGK 16 0 P29317 P29317 EPHA2 Ephrin type-A receptor 2 1 VLEDDPEAT(0.206)Y(0.711)T(0.06)T(0.017)S(0.005)GGK;VLEDDPEAT(0.233)Y(0.528)T(0.233)T(0.005)S(0.001)GGK 184.98 7.5917e-13 2637400.0 3308.4 2702.3 2771.6 2526.1 3179.0 2933.3 3119.6 3543.7 1442.6 2964.2 True False 3385.4792829742273 2385.913459734814 2395.231943309033 2084.964055769805 2891.460011298036 2903.7936652233066 2884.286060395631 3449.709564440143 2447.9868366647383 3344.683943753066 1.0121970685144572 0.7133449676735623 0.7161310257080212 0.6233665395093412 0.8644942421834728 0.8681817816140089 0.8623493606272337 1.0314007608650841 0.7319037845823647 1.0 11.707654174356025 -6.498896703008127 22.86936270872725 0.8948852352507188 0.757028427738604 0.21307615918819722 0.12024042212562268 389.32990950158023 371266.3708617591 0.036851256920727604 0.04149069237022694 3.1703214346873275e-07 6.498896703008127 -0.13785680751211482 VLENGEDHGVAGSPAS(ph)PASIEEER ddPTM_A459_Selumetinib_30min_R1 1 VLENGEDHGVAGSPASPASIEEER 24 0 H0Y7I6;E9PI60;Q9ULD4 H0Y7I6 BRPF3 Bromodomain and PHD finger-containing protein 3 1 VLENGEDHGVAGS(0.015)PAS(0.624)PAS(0.361)IEEER 58.581 0.0071543000000000015 3201000.0 594.48 922.28 765.6 801.59 823.92 579.06 608.16 665.22 394.37 658.49 True False 608.3302273432836 814.2990288436599 661.6357251397735 661.6073542078769 749.3965814748908 573.2351821444132 562.2860015675747 647.5762046609112 669.2170863548266 743.0136057357662 0.8187336310495782 1.0959409391128223 0.8904759213454664 0.8904377377487226 1.0085906579500707 0.7715002494157148 0.7567640716494999 0.8715536292496979 0.9006794508051265 1.0 9.53724481877251 -6.758112996841465 24.99999895279232 0.8456131217312035 0.9438550636531502 0.14503746881241453 0.09466062918174678 142.0384750500301 1067515.8898246507 0.03120599791198592 0.029989273793960367 1.745367975545838e-07 6.758112996841465 0.09824194192194668 VLENGEDHGVAGSPAS(ph)PASIEEER ddPTM_A459_Selumetinib_30min_R2 1 VLENGEDHGVAGSPASPASIEEER 24 0 H0Y7I6;E9PI60;Q9ULD4 H0Y7I6 BRPF3 Bromodomain and PHD finger-containing protein 3 1 VLENGEDHGVAGS(0.262)PAS(0.648)PAS(0.09)IEEER 93.553 1.4128e-05 2506400.0 6297.2 5700.2 8319.2 7756.5 10782.0 7973.7 5502.8 6496.6 5446.1 6727.7 True False 5947.226833688906 6137.3870109681675 7783.951729260092 6700.051319291178 9427.46876769702 9072.004796958177 5758.691103591339 6515.504030429975 6535.472176748086 6533.453820336153 0.9102730343294774 0.9393786471505806 1.1913992113989718 1.025499146934577 1.4429533026395476 1.3885465553794047 0.8814160567978192 0.9972526338442452 1.0003089264066811 1.0 12.673630138944079 -7.303469024493885 24.999874925156465 0.9695154595574722 1.14969937961064 0.2220763241618099 0.16497839323465868 888.9155687854235 528737.353758702 0.07664816612143635 0.051676767886372724 4.971998346116764e-08 7.303469024493885 0.18018392005316786 VLEQLTGQTPVFS(ph)K ddPTM_A459_Selumetinib_30min_R1 2 VLEQLTGQTPVFSK 14 0 P62913;Q5VVC8;P62913-2 P62913 RPL11 60S ribosomal protein L11 1 VLEQLTGQTPVFS(1)K;VLEQLTGQT(0.058)PVFS(0.942)K 216.77 1.2773e-08 33288000.0 3701.3999999999996 6230.3 7845.5 7232.7 6147.5 5908.3 6138.6 6529.1 2873.71 5606.5 True False 3787.635418329345 5500.8535796121105 6780.124192246722 5969.64471959394 5591.45971042928 5848.8678663071805 5675.560459784785 6355.927058494262 4876.475982525875 6326.148886934614 0.5987268851910746 0.8695422251242008 1.0717617168716502 0.9436459410436954 0.8838647035287635 0.9245542542299058 0.8971588499136516 1.0047071562955385 0.7708443272015386 1.0 12.627111794977486 -4.791398397467529 3.895906028429071 0.9356480201598868 0.5703432236995879 0.6322227020313271 0.07706702494886887 0.1419381421053249 3.9204691325969176 0.018707117416376966 0.14456592119108475 1.6165963821313777e-05 4.791398397467529 -0.3653047964602989 VLETAEDIQER ddPTM_A459_Selumetinib_30min_R1 1 VLETAEDIQER 11 0 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2;A0A0D9SFF6;A0A1B0GTB7 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 137.46 0.018441 2380100.0 832.81 946.45 825.31 932.04 1111.2 721.67 765.34 932.2 546.31 659.19 False True 852.2128526338314 835.6391940073322 713.237435103326 769.276710557653 1010.692156198294 714.4106550239333 707.6097876212307 907.4750277876508 927.048169096293 743.8034575543429 1.145750055311578 1.1234677461099052 0.9589057806325353 1.0342472903891402 1.3588161575928839 0.9604831058098944 0.95133973959718 1.2200467994212703 1.2463617366669233 1.0 9.538777644077019 -7.804604530706128 24.99951868146504 1.174903206290543 1.0782667594571944 0.06647737173660961 0.1300802893143728 360.64159742929064 208864.5256289293 0.07227715108894989 0.03472121208825097 1.5681784060659763e-08 7.804604530706128 -0.09663644683334849 VLGAGGAGPAPAT(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 VLGAGGAGPAPATPSR 16 0 B7WPE2;Q32P44;H7C355;G3V195 B7WPE2 EML3 Echinoderm microtubule-associated protein-like 3 1 VLGAGGAGPAPAT(0.986)PS(0.014)R 103.88 0.012568 0.0 42808.0 40603.0 34012.0 30327.0 26099.0 17653.0 27428.0 24263.0 17985.0 27975.0 True False 40428.90273400159 43717.119540777625 31823.70494946562 26196.410283006957 22820.21029197966 20084.540512021118 28703.45634755094 24333.60131304411 21582.502542886545 27167.28906222096 1.4881463749072532 1.609182257407162 1.171397885029313 0.9642629495718027 0.8399884964493428 0.7392913023460568 1.0565447395878076 0.8956948651487867 0.7944297457672852 1.0 14.729582990320251 -5.50830131284942 2.231342352085076 0.8867624711429822 1.559399580646692 0.8805963752387745 0.095180319588407 0.09498999920058958 0.9279214813982681 0.027567074731642726 0.06851594596252836 3.1024063964462445e-06 5.50830131284942 0.6726371095037098 VLGDHLLLDPTHELPPYTPPPMLS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 VLGDHLLLDPTHELPPYTPPPMLSPVR 27 0 Q05GC8;Q96PN7-2;Q96PN7-3;Q96PN7-4;Q96PN7-5;Q96PN7 Q05GC8 BCAR2;TRERF1 Transcriptional-regulating factor 1 1 VLGDHLLLDPTHELPPYT(0.002)PPPMLS(0.998)PVR 133.51 2.7508e-12 16456000.0 655.9 929.68 973.55 1300.9 904.83 797.33 886.12 1236.2 456.16 788.34 True False 671.181193840768 820.8326334034937 841.3472573273591 1073.722235917398 822.9882862607113 789.309584117717 819.2792549806956 1203.411960256484 774.0702033917838 889.531118081875 0.7545336865651849 0.9227700040145665 0.9458322932440899 1.207065401188775 0.9251933625833663 0.8873321776755051 0.9210237149964289 1.3528610026048786 0.8702002523092578 1.0 9.79690126532578 -4.826680304260881 1.6819026056333066 1.0235958551318187 0.6794632148697803 0.23335729656647886 0.14476769864702138 1.302453790203582 3.936956076186935 0.040627231251616144 0.7142978247584869 1.490457839709885e-05 4.826680304260881 -0.3441326402620384 VLGS(ph)EGEEEDEALS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 3 VLGSEGEEEDEALSPAK 17 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 2 VLGS(1)EGEEEDEALS(1)PAK;VLGS(1)EGEEEDEALS(1)PAK;VLGS(1)EGEEEDEALS(1)PAK 216.53 1.881e-10 60125900.0 19856.0 22333.2 22018.4 21447.0 17454.4 18982.9 20059.5 19532.8 13193.099999999999 19417.4 True False 20318.60616694967 19718.41856157699 19028.422218413765 17701.68406005105 15875.652601824613 18791.949261094152 18546.395765003905 19014.726692523753 22387.727114100628 21909.81243149275 0.9273747199106136 0.8999811670333656 0.868488595140261 0.8079340759032233 0.724590986411424 0.8576955790859696 0.8464881122553868 0.8678635087351246 1.0218128148792789 1.0 14.419289513110193 -8.211053650864946 4.366569354499271 1.0127884514987813 0.8454344066737792 0.6075897221978686 0.05178955856676428 0.1495290469152975 5.9945150656931405 0.04516313463327854 0.014903946433598545 6.151008811093732e-09 8.211053650864946 -0.16735404482500205 VLGS(ph)EGEEEDEALS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 2 VLGSEGEEEDEALSPAK 17 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 2 VLGS(1)EGEEEDEALS(1)PAK;VLGS(1)EGEEEDEALS(1)PAK 208.4 8.542400000000001e-08 15666300.0 97319.0 79051.0 85544.0 85961.0 85752.0 66547.5 74301.0 77924.0 58418.0 82475.0 True False 91910.399578824 85113.95751097261 80040.19217326478 74252.96350900394 74979.06712739338 75713.81406694186 77756.1437246383 78150.7459389873 70103.23233529863 80093.7324542154 1.1475354782768235 1.0626793745643828 0.9993315297051336 0.9270758302024411 0.9361415035846189 0.945315092041974 0.9708143364287168 0.9757410916473548 0.8752648951073954 1.0 16.28940173190879 -5.063682926519889 1.5026591422924254 0.9465582332235156 1.170647153644823 0.7975750703618649 0.03260516133938086 0.280944007246744 0.8621774765790242 0.009299721231910134 0.08032311802006434 8.63608828678494e-06 5.063682926519889 0.22408892042130746 VLGS(ph)EGEEEDEALSPAK ddPTM_A459_Selumetinib_30min_R1 6 VLGSEGEEEDEALSPAK 17 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK 346.09 2.3905999999999983e-155 271604600.0 21013.100000000002 23737.899999999998 26433.83 26277.5 22157.96 19739.61 23049.54 21337.94 11950.9 17131.55 True False 21502.66434562502 20958.65563254967 22844.26107663466 21688.627914766235 20153.77643030556 19541.047445531873 21310.89464050887 20771.988515802645 20279.804440798987 19330.551317928228 1.1123668431371772 1.084224411805133 1.1817697643960947 1.1219870327573636 1.0425867373794884 1.010889297679183 1.1024462929178829 1.0745678265543077 1.049106365734658 1.0 14.23859516413939 -6.253361586862509 18.826734840344248 1.0513346251914857 1.1262172433294337 0.5382433653005687 0.03544566576747395 18.34567372634716 42754.899174272294 0.010870436785697707 0.013670601130355413 5.580054146093452e-07 6.253361586862509 0.07488261813794805 VLGS(ph)EGEEEDEALSPAK ddPTM_A459_Selumetinib_30min_R2 5 VLGSEGEEEDEALSPAK 17 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK;VLGS(1)EGEEEDEALSPAK 292.38 6.455699999999999e-76 128688700.0 310690.0 265233.0 302672.0 334680.0 324085.0 225718.0 235466.0 258991.0 201169.0 254135.0 True False 293423.09359061264 285575.5182414866 283198.4130443565 289096.0066447972 283370.5449433401 256808.60563600424 246415.63556702755 259744.62093173197 241408.42113149507 246797.4622279721 1.1889226531817878 1.1571250192908968 1.1474932136164353 1.171389705692164 1.1481906758084273 1.0405642072558454 0.9984528744440984 1.0524606638450775 0.9781641146232732 1.0 17.912968034037824 -6.791108759231048 3.1919647677655534 1.0120630754324689 1.1643051560217217 0.931564066416427 0.020334265643116158 0.05801421617668113 1.218589129985384 0.007169293136585306 0.00655641089960701 1.6176748768257138e-07 6.791108759231048 0.15224208058925282 VLGSEGEEEDEALS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 5 VLGSEGEEEDEALSPAK 17 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK 302.34 2.6277999999999988e-89 334394900.0 14288.31 15242.199999999999 14647.499999999998 14827.5 11360.24 12390.35 13480.8 13248.490000000002 7177.810000000001 12253.56 True False 14621.199822788505 13457.636138093458 12658.449952958244 12238.155471646718 10332.70829781327 12265.714328537686 12463.932402545648 12897.0970080395 12180.2193234996 13826.42378578195 1.0574824010402344 0.9733273293656943 0.9155259631181881 0.8851280462147785 0.7473160419427217 0.8871212483122947 0.9014574264216185 0.9327861786864873 0.880937797959355 1.0 13.755140430202752 -4.992552849115387 1.685814508439743 0.8833665193061454 1.0789813340270493 0.4344830560863868 0.059346500994502394 0.5867965570743171 2.252687760645729 0.017278975017491288 0.16438286071463185 1.0172955643727394e-05 4.992552849115387 0.19561481472090392 VLGSEGEEEDEALS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 5 VLGSEGEEEDEALSPAK 17 0 P18858-3;P18858;M0R0Q7;P18858-2;B4E135;F5GZ28;M0QY71;M0R1G7 P18858-3 LIG1 DNA ligase 1;DNA ligase 1 VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK;VLGSEGEEEDEALS(1)PAK 170.47 8.564700000000002e-07 201568900.0 221463.0 175326.0 194931.0 200420.0 184759.0 152104.0 176015.0 178594.0 140573.0 171380.0 True False 209154.97304663097 188772.94043805622 182389.35168482564 173122.45025621544 161547.92265358326 173054.94533736244 184200.04626710562 179113.67897217162 168691.52793779183 166431.8141012841 1.2567006745437934 1.1342359119103043 1.0958803319528223 1.040200464022219 0.9706553012470999 1.039794862970416 1.1067598299145405 1.0761985617916163 1.0135774151637411 1.0 17.34457171115546 -4.749981297247369 1.213953999321642 1.0399597056550007 1.3649379116350855 0.7699083864674903 0.03736586199068007 0.8349919712995594 0.9984457610107947 0.012472278023210132 0.3504915090370625 1.7783559927206033e-05 4.749981297247369 0.32497820598008476 VLGT(ph)SPEAIDSAENR ddPTM_A459_Selumetinib_30min_R1 2 VLGTSPEAIDSAENR 15 0 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 VLGT(0.607)S(0.383)PEAIDS(0.01)AENR;VLGT(0.637)S(0.363)PEAIDSAENR 204.17 1.6937e-05 11501000.0 3178.0 3316.9 3595.3 4569.4 3689.7 3010.3 3246.4 2871.9 1851.35 2492.8 True False 3252.0412166884607 2928.5558060150256 3107.078007569261 3771.4400682611677 3355.967286469443 2980.0191151337117 3001.5214343083635 2795.7278827540827 3141.60573274592 2812.775161928226 1.1561682073653932 1.0411624240906012 1.1046307751947309 1.3408252886006549 1.1931160840345467 1.0594586995324702 1.0671032206679283 0.9939393381295157 1.116906098741384 1.0 11.457778520665176 -6.810229929257315 6.95425656667537 1.0475318297053653 1.1662804434861735 0.3694871979564366 0.078216236227993 0.26464371190475156 29.392493970125653 0.03010325421534661 0.02675844569797545 1.5479968433541205e-07 6.810229929257315 0.11874861378080825 VLGT(ph)SPEAIDSAENR ddPTM_A459_Selumetinib_30min_R2 1 VLGTSPEAIDSAENR 15 0 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 VLGT(0.64)S(0.36)PEAIDSAENR 217.39 7.5266e-09 4477800.0 19726.0 20854.0 23257.0 25902.0 26742.0 18715.0 17574.0 18123.0 15413.0 22108.0 True False 18629.707889434576 22453.4347438213 21760.669940307012 22374.10291655773 23382.430883486708 21292.821372144965 18391.225822220356 18175.73492957584 18496.030675202113 21469.684596517644 0.8677215450317464 1.045820428468857 1.0135533124616356 1.0421253659304703 1.0890905629456387 0.9917621880481018 0.8566136935799882 0.8465767090273847 0.8614952209499224 1.0 14.390013376783294 -7.181331931793243 5.014087671521168 0.8785963602780366 1.017174836372405 0.41357549050596976 0.0676326880502529 0.19168284109538813 8.533925461358661 0.026080675692082472 0.019909738938387055 6.586702803270875e-08 7.181331931793243 0.13857847609436835 VLGTS(ph)PEAIDSAENR ddPTM_A459_Selumetinib_30min_R1 2 VLGTSPEAIDSAENR 15 0 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 VLGT(0.172)S(0.82)PEAIDS(0.008)AENR;VLGT(0.037)S(0.963)PEAIDSAENR 139.64 0.00039276 12311800.0 3164.8 3887.6 3902.1 3960.3 3477.3 3353.2 3325.7 3910.4 1815.62 3067.9 True False 3238.533682371188 3432.437984703793 3372.2162527010305 3268.707949038103 3162.778828967176 3319.4698524620017 3074.8397714635703 3806.6834892306697 3080.9745323618667 3461.694848876605 0.9355341310405111 0.9915483988479497 0.9741517955562685 0.9442507476067307 0.9136503842889463 0.958914634991366 0.8882469153690489 1.0996588825459357 0.8900190995638191 1.0 11.757262840269116 -10.944879673463463 3.2078025047441487 1.0005913528476902 0.9575984332225129 0.049742688921855405 0.05795044627204645 80484638.47914492 92998862.13419424 425632.8432246687 0.013697206757456303 1.1353253277079768e-11 10.944879673463463 -0.04299291962517726 VLGTS(ph)PEAIDSAENR ddPTM_A459_Selumetinib_30min_R2 1 VLGTSPEAIDSAENR 15 0 P27708;F8VPD4 P27708 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 VLGT(0.157)S(0.843)PEAIDSAENR 154.13 0.00019416 4855800.0 15768.0 11387.0 12396.0 16595.0 16073.0 14557.0 13277.0 16095.0 11694.0 14583.0 True False 14891.677684305196 12260.346285024138 11598.454855744323 14334.732372028244 14053.766045556875 16562.09461471088 13894.406807876392 16141.833785329305 14033.12675766001 14161.950898815663 1.0515272783180287 0.8657243887245398 0.8189870829670988 1.0122004005272345 0.9923608792297228 1.1694783249175038 0.9811082461130659 1.139802976345527 0.9909035031913275 1.0 13.78973239907887 -5.940339790432546 6.36450827584338 1.051077667858497 0.9072702262805272 0.34654952326656163 0.08176720612092764 0.20652097492126462 16.551249726787844 0.022629544152431968 0.03371797659916259 1.1472556615804209e-06 5.940339790432546 -0.14380744157796976 VLIAAHGNSLR ddPTM_A459_Selumetinib_30min_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 108.9 0.013634 10511000.0 2651.0 3390.9 3078.6 3163.7 3377.8 2666.6 3158.5 2609.2 1316.3 1740.6 False True 2712.7631420519538 2993.891851613356 2660.5430295393226 2611.2191850041277 3072.278586399027 2639.776425079079 2920.251802077062 2539.9955401239426 2233.664961251763 1964.0229648797622 1.3812278117725725 1.5243670288736377 1.3546394706755385 1.3295257905316737 1.5642783416165973 1.34406596678501 1.4868725337210302 1.293261629595783 1.1372906535176428 1.0 10.93959608352266 -8.27433761224215 1.787101844727789 1.0070973406574093 1.4266784398859382 0.7779350448388845 0.07696557093940844 0.14709183431081327 0.883810833503658 0.06913138351533868 0.020455129933083658 5.316947692012682e-09 8.27433761224215 0.41958109922852893 VLIAAHGNSLR ddPTM_A459_Selumetinib_30min_R2 2 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 ; 172.56 1.2044e-07 5481600.0 77940.0 53617.0 81819.0 112116.0 111715.0 90870.0 70110.0 84965.0 76612.0 85367.0 False True 73608.40681854055 57729.25149417218 76554.85461779167 96845.60738911248 97680.36295522848 103386.51766426994 73370.25392032947 85212.2340832871 91936.54071813326 82902.23289989702 0.8878941404077909 0.6963533969450405 0.9234353761041673 1.1681905782447601 1.1782597348514823 1.24708966270073 0.8850214445842823 1.0278641612244555 1.108975446163736 1.0 16.339123339536158 -5.550107305025978 4.827321021530508 1.0898872302649778 0.7938180975325936 0.5637705812559961 0.10569818124365768 0.13305141265019815 7.817245004767835 0.030427193180812988 0.05664927184465322 2.817686654181269e-06 5.550107305025978 -0.2960691327323842 VLIGGDET(ph)PEGQR ddPTM_A459_Selumetinib_30min_R2 1 VLIGGDETPEGQR 13 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 1 VLIGGDET(1)PEGQR 104.9 0.017499 2590100.0 22452.0 19423.0 22186.0 22926.0 22213.0 14504.0 21856.0 16100.0 16069.0 19250.0 True False 21204.207722477182 20912.681645211527 20758.576914290385 19803.43925044407 19422.404353260437 16501.79434579699 22872.347306842385 16146.848334501512 19283.249005373575 18694.20248249343 1.134266505475925 1.118672040960059 1.1104285905606393 1.0593358699837239 1.0389533531290756 0.8827225639205755 1.2234994955394145 0.8637356073158274 1.0315095829004617 1.0 14.190303304926122 -5.982663113186219 1.7894667777249385 1.0035951249440263 1.1254540487885951 0.24125122685824385 0.09183885893797986 0.5132061608324876 3.315342061764699 0.029134857002895732 0.048546589410143316 1.0407271558333724e-06 5.982663113186219 0.12185892384456887 VLIGGDETPEGQR ddPTM_A459_Selumetinib_30min_R2 1 VLIGGDETPEGQR 13 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 0 144.17 0.0094664 1815900.0 6498.3 7967.7 7386.2 8416.2 11548.0 5774.6 5344.1 6396.5 6228.2 6786.8 False True 6137.150500755988 8578.796969806514 6910.979933486502 7269.899041245202 10097.23699957014 6569.998733400388 5592.611239133255 6415.112756002423 7474.014030447923 6590.847449775916 0.931162577729613 1.3016227480880604 1.0485722793844166 1.1030294809042156 1.5320089072784469 0.9968367168965143 0.8485420549861763 0.9733365557141719 1.1339989413200624 1.0 12.68624826324658 -6.960254431901592 24.99996090152534 0.9775951078713302 1.1865629534538256 0.2580922913793434 0.1629285876011984 205.84746249057932 129477.46251291425 0.05707478357652963 0.050335168312241975 1.0958360113124094e-07 6.960254431901592 0.20896784558249537 VLISVGS(ph)YK ddPTM_A459_Selumetinib_30min_R1 1 VLISVGSYK 9 0 Q8TEV9-2;Q8TEV9 Q8TEV9-2 SMCR8 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 1 VLIS(0.082)VGS(0.918)YK 128.51 0.004305600000000001 27683000.0 3862.9 4309.7 5068.6 5080.9 3475.1 4156.7 3924.0 3801.6 2116.6 3522.3 True False 3952.898054105049 3805.1183204748245 4380.311959826876 4193.616195305331 3160.777818578735 4114.88737198163 3628.0095207694762 3700.769218662877 3591.7156096524227 3974.421515107427 0.9945845047082793 0.9574018020008565 1.1021256661319372 1.0551513419914593 0.7952799688115871 1.0353424659010801 0.912839643952917 0.9311466346978163 0.9037077713070251 1.0 11.956529173230154 VLISVGS(ph)YK ddPTM_A459_Selumetinib_30min_R2 2 VLISVGSYK 9 0 Q8TEV9-2;Q8TEV9 Q8TEV9-2 SMCR8 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 1 VLISVGS(1)YK;VLISVGS(1)YK 141.89 0.0021677 13623200.0 161761.0 137311.0 138542.0 136171.0 145758.0 118427.0 132319.0 128332.0 100890.0 141095.0 True False 152770.97120058932 147842.3121755468 129628.3585531246 117624.27489192261 127446.57694694694 134739.24427673052 138472.09568512448 128705.42487349382 121070.81910213095 137021.22074116438 1.1149438778477716 1.0789738361390289 0.9460458595533533 0.8584383809725141 0.9301229127690803 0.9833458171508737 1.0105886879135375 0.9393101606985442 0.8835917418283403 1.0 17.06403981789424 -5.219160161281655 4.093676279607656 0.941503968922702 1.1047225710163016 0.6485452743318256 0.045313026015462526 0.1377558659353907 5.073348924394964 0.012726792144519748 0.03588798105505398 6.037259432575791e-06 5.219160161281655 0.1632186020935995 VLLPEYGGTK ddPTM_A459_Selumetinib_30min_R2 1 VLLPEYGGTK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 138.08 0.023215 5650900.0 104110.0 72300.0 74907.0 89073.0 75033.0 64356.0 98730.0 78159.0 79350.0 76073.0 False True 98323.98298535096 77845.17751885895 70087.56517257493 76941.10374050429 65606.68373646912 73220.45483439816 103321.14062978367 78386.42975008105 95222.21722424481 73876.57482860892 1.330922328403275 1.0537193650281844 0.9487116225295453 1.0414817405788637 0.8880580060550226 0.9911187004035726 1.3985643063377682 1.0610458041934785 1.2889365464649254 1.0 16.172829359130084 VLLQAS(ph)QDENFGNTTPR ddPTM_A459_Selumetinib_30min_R1 1 VLLQASQDENFGNTTPR 17 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 VLLQAS(0.821)QDENFGNT(0.171)T(0.008)PR 144.08 0.0004947 16034000.0 2595.5 3035.9 3237.5 3653.0 2844.2 2681.9 3030.2 2422.0 1460.7 2309.0 True False 2655.970100036155 2680.4554166483804 2797.865282314545 3015.0721253026754 2586.9426121842944 2654.9225209703704 2801.6295743719847 2357.7606922352415 2478.7012146930433 2605.3826415646163 1.0194165178137364 1.0288144911561552 1.0738788374802162 1.157247337570357 0.9929223335236286 1.0190144351986639 1.075323650997197 0.9049575500431408 0.951377035814019 1.0 11.347279555264985 -7.755315416056878 24.999967617393697 0.9461254638956369 1.0527588627495363 0.47835893203082724 0.047856098681920436 120.47541764130695 491824.8539595892 0.024055618486463096 0.013433967214256276 1.7566473462286775e-08 7.755315416056878 0.10663339885389944 VLLQAS(ph)QDENFGNTTPR ddPTM_A459_Selumetinib_30min_R2 1 VLLQASQDENFGNTTPR 17 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 VLLQAS(1)QDENFGNTTPR 134.4 0.00055588 6757800.0 17388.0 16280.0 16619.0 17029.0 17587.0 15429.0 17605.0 12387.0 15530.0 18002.0 True False 16421.64456967902 17528.623651549387 15549.751633399077 14709.620823336492 15377.56383022515 17554.20469948302 18423.6673836457 12423.044119221753 18636.433944455257 17482.235485186844 0.9393332210628046 1.0026534459166763 0.8894601406424704 0.8414038831475722 0.8796108394292573 1.0041167054612186 1.0538507732181366 0.710609585927848 1.0660212168087082 1.0 14.093602056217655 -6.745380234464297 24.998132559481633 0.9542659673233838 0.9106056785982299 0.06567967988550705 0.1009189150605179 971.9912569617514 1513028.2804006343 0.033653866648506954 0.033552870605606286 1.7972966529421855e-07 6.745380234464297 -0.04366028872515382 VLLQASQDENFGNT(ph)TPR ddPTM_A459_Selumetinib_30min_R1 1 VLLQASQDENFGNTTPR 17 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 VLLQAS(0.002)QDENFGNT(0.998)TPR 220.78 1.3367000000000003e-11 17495000.0 2126.9 2414.2 2549.8 2886.0 2237.1 2323.4 2433.2 2325.5 1123.7 1713.4 True False 2176.452631773029 2131.5443416688686 2203.551165048843 2382.014276929517 2034.7546999920837 2300.0287054784117 2249.661765019442 2263.8201857114186 1906.836828199199 1933.331579929326 1.1257523822440176 1.102523935261425 1.1397688776849106 1.2320774675478032 1.052460282093186 1.189671099027147 1.1636192096451865 1.170942537334529 0.9862958056418365 1.0 10.916873375752651 -8.265344371172834 24.77932191522888 0.9931478724758055 1.14701894294414 0.6390260590173573 0.046283849944009706 189.48637548267016 1202366.1975107894 0.03856317953596985 0.01144474064299574 5.428197351820632e-09 8.265344371172834 0.15387107046833448 VLLQASQDENFGNTT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VLLQASQDENFGNTTPR 17 0 P57740;G3V1T4 P57740 NUP107 Nuclear pore complex protein Nup107 1 VLLQASQDENFGNT(0.259)T(0.741)PR 102.39 0.0084252 7526900.0 18542.0 19848.0 17580.0 19411.0 22560.0 19217.0 18543.0 18888.0 17063.0 20019.0 True False 17511.509869507034 21370.277778621155 16448.921939656753 16767.188314157283 19725.811111041065 21863.96731544267 19405.286242257447 18942.960952923277 20476.076780054093 19440.99945439147 0.9007515231194254 1.0992376101216281 0.8460944602280288 0.8624653456471238 1.0146500521908743 1.1246318568515716 0.9981629950549711 0.9743820525978313 1.0532419811075513 1.0 14.246814768803306 -6.447955693708477 9.431091781450464 1.0312367807902436 0.9340342328404936 0.302457373362627 0.07467641815741226 0.6497643762673077 78.40512451037773 0.02406016443372995 0.027257476336092868 3.5648750007171497e-07 6.447955693708477 -0.09720254794975003 VLLS(ph)DSNLHDA ddPTM_A459_Selumetinib_30min_R2 2 VLLSDSNLHDA 11 0 H3BV90;Q6FI81-3;Q6FI81;Q6FI81-2 H3BV90 CIAPIN1 Anamorsin 1 VLLS(0.595)DS(0.405)NLHDA;VLLS(0.991)DS(0.009)NLHDA 82.505 0.039861 12135900.0 63636.0 66006.0 72550.0 75273.0 92099.0 47229.0 54191.0 66520.0 64873.0 64497.0 True False 60099.365875091644 71068.44795725857 67882.21198646746 65020.68754683228 80528.70024449346 53734.36604782447 56710.98887742935 66713.56218702123 77849.4127030679 62634.80402666899 0.9595202988022794 1.1346478856547337 1.0837778299356409 1.0380919770922794 1.2856861531841866 0.8578994838867087 0.9054229474923021 1.0651196762524484 1.2429098152829015 1.0 15.934676915998987 -6.7759862657844865 24.999995339017882 1.0115374849224246 1.0978717349295035 0.10893980553648841 0.12285863858194218 607.5431089197368 1044105.6412045857 0.0447343000285813 0.039624002724092035 1.6749958455923345e-07 6.7759862657844865 0.08633425000707895 VLMKS(ph)PSPALHPPQK ddPTM_A459_Selumetinib_30min_R1 1 VLMKSPSPALHPPQK 15 1 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 VLMKS(0.992)PS(0.008)PALHPPQK 85.36200000000002 0.011437 23048000.0 6287.9 6967.3 8790.4 8863.1 8009.4 7621.1 8094.7 6917.2 3504.1 5636.7 True False 6434.395835876454 6151.565276990103 7596.7119622109 7315.3259659923815 7284.951184174418 7544.438653405149 7484.1102619196445 6733.733385767801 5946.201770661939 6360.225351107518 1.011661612706226 0.9671929746827161 1.194409245403242 1.1501677318270729 1.1453919919529072 1.1861904629041835 1.1767052028457485 1.058725597607205 0.9349042592691336 1.0 12.634862167650589 -8.042748893418672 4.717338699882208 0.9719978500150553 1.120843610139476 0.40903987615025605 0.07217724680351069 0.22737356371764403 11.460930496689615 0.05504661591925073 0.020770727747542742 9.062564417253126e-09 8.042748893418672 0.14884576012442075 VLMKS(ph)PSPALHPPQK ddPTM_A459_Selumetinib_30min_R2 2 VLMKSPSPALHPPQK 15 1 Q9H6S0 Q9H6S0 YTHDC2 Probable ATP-dependent RNA helicase YTHDC2 1 VLMKS(0.835)PS(0.165)PALHPPQK;VLMKS(0.994)PS(0.006)PALHPPQK 82.774 0.013609 24494600.0 155235.0 118789.0 174648.0 199619.0 229387.0 158861.0 142055.0 150176.0 111546.0 174376.0 True False 146607.6601549413 127899.73433316327 163411.33782236517 172430.54783801813 200569.35431420113 180742.6607534237 148660.83897664232 150612.987297025 133858.31685564763 169341.31179674107 0.8657524770500964 0.7552778053749828 0.9649821185896233 1.0182426603910157 1.1844088851451844 1.0673276286554787 0.8778769775627974 0.8894048693670479 0.790464626944172 1.0 17.36957444444399 -5.319357763388163 7.246040709721177 0.9795744191459602 0.8108960657296669 0.2754362114383042 0.10586919385125901 0.3361306554924765 36.82335676219348 0.03127888708860832 0.06603058547527266 4.793384162395908e-06 5.319357763388163 -0.16867835341629334 VLNT(ph)GSDVEEAVADALKKPAR ddPTM_A459_Selumetinib_30min_R1 2 VLNTGSDVEEAVADALKKPAR 21 2 E3W994;J3KR49;O75122 E3W994 CLASP2 CLIP-associating protein 2 1 VLNT(0.592)GS(0.408)DVEEAVADALKKPAR;VLNT(0.599)GS(0.401)DVEEAVADALKKPAR 106.99 0.00017471 21746000.0 10110.5 7155.6 22872.5 23148.2 15673.800000000001 11506.8 10202.1 11166.7 7173.2 6398.799999999999 True False 10346.05497839166 6317.819025451814 19766.540129649256 19105.801415530088 14256.107557434138 11391.052039338472 9432.547383242172 10870.522841446438 12172.396490200685 7220.14830959015 1.4329421688817012 0.8750262120045624 2.737691704115604 2.64617852657581 1.9744895736419272 1.5776756308742752 1.3064201701665057 1.5055816550205325 1.6858928609586479 1.0 12.817812756582383 -6.874214394468521 4.000404602396515 1.419947381721601 1.9583025826501224 0.1977823557653695 0.5291641802309 0.44464595668787915 13.098755217952593 0.21445311227207373 0.18884820313753112 1.3359358536276693e-07 6.874214394468521 0.5383552009285213 VLNTGS(ph)DVEEAVADALK ddPTM_A459_Selumetinib_30min_R1 1 VLNTGSDVEEAVADALK 17 0 E3W994;J3KR49;O75122 E3W994 CLASP2 CLIP-associating protein 2 1 VLNT(0.062)GS(0.938)DVEEAVADALK 221.51 4.9256e-12 5931200.0 1800.4 2440.1 1999.7 2311.8 2434.7 2410.0 2590.1 2406.5 1560.0 2275.9 True False 1842.345817031436 2154.411957628287 1728.1517235658362 1908.0875278605874 2214.4818148811974 2385.7575881049224 2394.7266716985264 2342.6718025863374 2647.2060621079927 2568.033934143313 0.7174149034934914 0.8389343804940766 0.6729473861654174 0.743014919893229 0.8623257603564107 0.9290210524031889 0.9325136400494639 0.9122433202456276 1.0308298605061428 1.0 11.326448551100814 -6.539673756275382 1.9695649029276958 0.9586522051211527 0.7435733343052936 0.8071935102020241 0.050225173653413786 0.14789956575709085 1.1588970432454544 0.01882272488865896 0.02015651304203505 2.8861988128900446e-07 6.539673756275382 -0.21507887081585908 VLNTGS(ph)DVEEAVADALK ddPTM_A459_Selumetinib_30min_R2 5 VLNTGSDVEEAVADALK 17 0 E3W994;J3KR49;O75122 E3W994 CLASP2 CLIP-associating protein 2 1 VLNT(0.003)GS(0.997)DVEEAVADALK;VLNT(0.083)GS(0.917)DVEEAVADALK;VLNT(0.104)GS(0.896)DVEEAVADALK;VLNT(0.008)GS(0.992)DVEEAVADALK;VLNT(0.006)GS(0.994)DVEEAVADALK 205.68 3.173e-29 41258150.0 143592.3 113769.76 124873.58 145982.09 153213.94 105663.59 130614.08 128751.48 99614.0 146515.06 True False 135612.01481152067 122495.53476456345 116839.34981487399 126099.07750884851 133965.83510719775 120217.79040393056 136687.8935268894 129126.125490845 119539.58344771186 142284.7895259573 0.9531026841543079 0.8609179883013168 0.8211654260735912 0.8862442565292195 0.9415330728851947 0.8449096407595906 0.9606641298924868 0.9075188284077846 0.8401430950277647 1.0 17.118421918111764 -6.010217420959592 24.69087319024269 0.910235285456379 0.8728238347655212 0.08479102967019492 0.05479333171750295 1072.2150767384146 2591070.4223669316 0.015400785823508931 0.021373034451850095 9.767481088737205e-07 6.010217420959592 -0.03741145069085783 VLPCGPS(ph)PQHHR ddPTM_A459_Selumetinib_30min_R2 2 VLPCGPSPQHHR 12 0 P98174 P98174 FGD1 FYVE, RhoGEF and PH domain-containing protein 1 1 VLPCGPS(1)PQHHR;VLPCGPS(1)PQHHR 106.3 0.0059267 6687900.0 44488.0 43106.0 45057.0 43512.0 53827.0 35586.0 41651.0 39516.0 33484.0 42275.0 True False 42015.53505957443 46412.09159236412 42158.08167435236 37585.59053761332 47064.771040514555 40487.64848245526 43587.85402989077 39630.98501777404 40181.7356211294 41054.41090635891 1.023410983911272 1.1305019501613494 1.026883122754113 0.9155067557379492 1.1463998630467427 0.9861948469995981 1.0617094014406976 0.9653283080390175 0.9787434464174873 1.0 15.32524961375384 -7.765114863319858 24.993423431550244 0.9790268966930126 1.0414348979965942 0.16128740239394557 0.06279746995039413 173.4487080663987 1179420.4773862313 0.03233409199408502 0.01649145744377982 1.717454090415134e-08 7.765114863319858 0.062408001303581595 VLPEAGAGEDS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 1 VLPEAGAGEDSPGR 14 0 R4GNH0;Q8WTV1-3;Q8WTV1 R4GNH0 THAP3 THAP domain-containing protein 3 1 VLPEAGAGEDS(1)PGR 135.86 0.00059989 3171000.0 830.6 1346.4 899.48 1152.8 2952.7 1010.6 1579.4 936.87 491.36 609.82 True False 849.951363933743 1188.762862075621 777.3355564899732 951.485120736087 2685.6288063415245 1000.4342815513833 1460.2645864177657 912.0211642173532 833.802032485502 688.0963371498201 1.2352214625271025 1.727611088586263 1.1296900078116867 1.382778935689813 3.9029837267637992 1.4539160107948044 2.1221804383763496 1.3254265645346368 1.2117518833761167 1.0 9.426466753827848 VLPEAGAGEDS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 VLPEAGAGEDSPGR 14 0 R4GNH0;Q8WTV1-3;Q8WTV1 R4GNH0 THAP3 THAP domain-containing protein 3 1 VLPEAGAGEDS(1)PGR 102.63 0.011463 0.0 7451.3 5891.8 30340.0 18368.0 49910.0 22983.0 9327.2 10026.0 40626.0 17313.0 True False 7037.186575917258 6343.682114877067 28387.957431694325 15866.246713432643 43639.85959893881 26148.699631098454 9760.93328149617 10055.174000106346 48752.33518528262 16813.12870542382 0.41855306642880225 0.3773052729222629 1.688439904854623 0.9436819875359832 2.595582319242036 1.5552548302721927 0.5805542473690426 0.5980548996132173 2.899658715486749 1.0 14.03730059596151 -5.254158828001806 23.760772520032873 1.459171754274252 0.3979288468717745 0.2573806384530307 0.7361479328980222 398.45048568096325 1300362.5292826737 0.1893453825030698 0.4781040496294193 5.569820150082618e-06 5.254158828001806 -1.0612429074024774 VLPEGAT(ph)CDEEEDEVQLRS(ph)T(ph)RR ddPTM_A459_Selumetinib_30min_R2 1 VLPEGATCDEEEDEVQLRSTRR 22 2 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 3 VLPEGAT(1)CDEEEDEVQLRS(1)T(1)RR 64.705 0.009715 12301000.0 13575.0 14863.0 12609.0 15748.0 15198.0 10904.0 11234.0 12135.0 11528.0 13730.0 True False 12820.55584503064 16002.94430792252 11797.750667641192 13603.095233184735 13288.691368156125 12405.927023343243 11756.403259748698 12170.310840942611 13833.922119232477 13333.579225175834 0.9615239560600107 1.2001986891641607 0.884814982414117 1.0202133278287357 0.9966334728086399 0.9304273679132575 0.8817139840104459 0.912756480117747 1.0375250250219326 1.0 13.702776484603596 -5.27581313048418 24.99593959065469 0.954785664336615 1.0808613420624988 0.300563178320404 0.07483323568434916 795.6398790165229 1383617.3263198817 0.01888958651559255 0.03960587147058212 5.2989139808575934e-06 5.27581313048418 0.1260756777258838 VLPITVPKS(ph)PAFALK ddPTM_A459_Selumetinib_30min_R1 2 VLPITVPKSPAFALK 15 1 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 1 VLPIT(0.008)VPKS(0.992)PAFALK;VLPIT(0.124)VPKS(0.876)PAFALK 87.15700000000002 0.010419 50378000.0 8040.1 5671.700000000001 26807.0 29781.0 13397.8 13589.599999999999 8225.1 7006.8 7982.6 4122.5 True False 8227.41868668876 5007.654727298203 23166.756640310738 24580.30740860635 12185.971355573709 13452.900962369553 7604.674084933999 6820.9569027059815 13545.889173963627 4651.66303155051 1.7687047902836515 1.0765299836495321 4.980317035687924 5.284197767956797 2.6197020878169317 2.892062660412739 1.6348290994756731 1.4663480257365922 2.912052975911383 1.0 12.183530875815698 -7.081233490876094 2.526956513288038 1.7895134106538242 3.2464094210908168 0.20830559226485534 1.284150656357392 0.5333670798458955 6.692602402634043 0.6081055994830125 0.45958923316390243 8.294047325920429e-08 7.081233490876094 1.4568960104369926 VLPPPAGYVPIRT(ph)PAR ddPTM_A459_Selumetinib_30min_R1 3 VLPPPAGYVPIRTPAR 16 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 VLPPPAGYVPIRT(1)PAR;VLPPPAGYVPIRT(1)PAR;VLPPPAGYVPIRT(1)PAR 115.53 0.0027589000000000003 170222000.0 11476.6 12729.7 14545.0 14750.3 13226.599999999999 12254.8 13263.400000000001 13071.4 7118.400000000001 9982.3 True False 11743.98245042378 11239.300806123021 12569.868889966045 12174.437002423243 12030.2563653459 12131.527838468122 12262.931059575392 12724.704010108888 12079.404892634324 11263.625440836056 1.0426467492292668 0.9978404258166428 1.1159700716249163 1.0808630903407936 1.0680625371055432 1.0770535563518921 1.0887197132032083 1.1297165443708488 1.0724260102649255 1.0 13.45938364423806 -5.255975464161571 24.99978572772315 1.083673214882457 1.0202435855857703 0.3163774204720322 0.034081467169401664 452.60580969068843 2070850.9194695246 0.008232495948580621 0.020489518251019734 5.54657047897358e-06 5.255975464161571 -0.06342962929668672 VLPPPAGYVPIRT(ph)PAR ddPTM_A459_Selumetinib_30min_R2 2 VLPPPAGYVPIRTPAR 16 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 VLPPPAGYVPIRT(1)PAR;VLPPPAGYVPIRT(1)PAR 136.33 0.00056774 74795000.0 176905.0 136056.0 202506.0 199611.0 172198.0 150060.0 146385.0 152361.0 138067.0 159524.0 True False 167073.32830682464 146491.0577110079 189476.9844318617 172423.63745181882 150564.94777034796 170729.40289094718 153192.1925563745 152804.3452852788 165684.25791430162 154918.12762687192 1.0784620939211784 0.9456030740562457 1.2230781983644066 1.1129984598517082 0.9719001260652413 1.1020621376354194 0.9888590502807107 0.9863554874179459 1.0694956132787794 1.0 17.241146444304874 -6.247219847419596 24.77023118001436 1.0216646940026903 1.089221911419126 0.18169401877256675 0.07296940772866449 1378.805832411237 2401861.5892806128 0.02199979825276699 0.02824819193639801 5.65952721401501e-07 6.247219847419596 0.06755721741643561 VLPPPAGYVPIRT(ph)PARK ddPTM_A459_Selumetinib_30min_R1 1 VLPPPAGYVPIRTPARK 17 2 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 VLPPPAGYVPIRT(1)PARK 77.795 0.025214 18209000.0 10269.0 10241.0 13318.0 14507.0 12097.0 10972.0 11276.0 11139.0 7022.2 9837.8 True False 10508.247720004345 9041.978959088265 11509.488750537495 11973.624780116603 11002.828485898819 10861.631641778915 10425.442241640312 10843.55753542871 11916.160518804334 11100.577458286863 0.9466397364904355 0.8145503234462994 1.036836938779736 1.0786488203078108 0.9911942443755417 0.9784744696926042 0.9391801715556207 0.976846256528188 1.073472129137626 1.0 13.438347107884951 -5.271619316887692 24.999188124717325 1.0067251113261806 0.8805950272819235 0.5063556316680273 0.05079204485269448 512.3935672913482 1258302.136689203 0.013772402756598894 0.029198325811461475 5.350331400238177e-06 5.271619316887692 -0.12613008404425707 VLPQPTNLAT(ph)PNTK ddPTM_A459_Selumetinib_30min_R2 2 VLPQPTNLATPNTK 14 0 A0A2R8Y6S3;C9J167;P54278 A0A2R8Y6S3 PMS2 Mismatch repair endonuclease PMS2 1 VLPQPT(0.004)NLAT(0.988)PNT(0.008)K;VLPQPTNLAT(0.998)PNT(0.002)K 133.25 0.0020492 3538400.0 32066.0 36565.0 37223.0 41719.0 45471.0 39208.0 38481.0 37574.0 33298.0 35755.0 True False 30283.900090368486 39369.41792499408 34828.11270533809 36036.800230710825 39758.52646410234 44608.5461052129 40270.44274865494 37683.33411928944 39958.530423855205 34722.66024735338 0.8721653201291447 1.1338249328979593 1.0030369924779237 1.0378467540792071 1.1450311174568717 1.2847099210554596 1.1597741204671788 1.085266331866428 1.1507911588341193 1.0 15.083589862430943 -6.2275157722550025 4.4417805337521115 1.1507975097295238 1.0176459722165758 0.31736385636897146 0.08944776276882208 0.25300045247741393 11.972078870383122 0.026915818174840817 0.03411808029484676 5.922215787986337e-07 6.2275157722550025 -0.13315153751294795 VLPSFWIPSLT(ph)PEAK ddPTM_A459_Selumetinib_30min_R1 2 VLPSFWIPSLTPEAK 15 0 A0A075B797;M0R3B2;Q9Y314;A0A075B6F9 A0A075B797 NOSIP Nitric oxide synthase-interacting protein 1 VLPSFWIPS(0.006)LT(0.994)PEAK;VLPS(0.165)FWIPS(0.179)LT(0.657)PEAK 162.7 0.00025612 34694000.0 9701.2 11429.2 12511.3 12776.5 10225.9 10137.900000000001 10228.7 9751.4 6100.0 8374.5 True False 9927.21908475082 10091.063950709067 10812.33417965158 10545.324119608442 9300.969150529281 10035.921930476716 9457.140923826386 9492.761194988734 10351.254473627403 9449.448649537833 1.0505606679217578 1.0678997606069445 1.144229105915127 1.115972424499519 0.9842869669421598 1.062064285726085 1.0008140447738112 1.0045836055686719 1.0954347557763253 1.0 13.206014438992332 -6.250558093508337 24.994848914377506 1.0254506449906255 1.0962939123504498 0.43672943725891167 0.038994486957402916 718.9453946604184 1651451.7849000515 0.011698645761193957 0.014939332403592007 5.616191482071655e-07 6.250558093508337 0.07084326735982427 VLPSFWIPSLT(ph)PEAK ddPTM_A459_Selumetinib_30min_R2 1 VLPSFWIPSLTPEAK 15 0 A0A075B797;M0R3B2;Q9Y314;A0A075B6F9 A0A075B797 NOSIP Nitric oxide synthase-interacting protein 1 VLPS(0.009)FWIPS(0.204)LT(0.787)PEAK 109.48 0.008739100000000001 34813000.0 45635.0 46874.0 51583.0 56450.0 50987.0 31801.0 41698.0 37585.0 47635.0 40447.0 True False 43098.78939137922 50469.0850763345 48264.20593932389 48761.412618318456 44581.55723043665 36181.29908926432 43637.03962301949 37694.36612746828 57163.331033105365 39279.190016073335 1.0972423151735786 1.2848810032916202 1.2287474848532727 1.241405757052651 1.1349917656701562 0.9211314967151478 1.1109455058814321 0.9596523276585762 1.4553082945374818 1.0 15.261477559409727 -6.515579063986723 24.321634016969227 1.0815463437223711 1.2154285036108765 0.1398576482263889 0.14403021380490785 440.6813504875169 1468304.049842331 0.04508059774555303 0.04694739326609925 3.0508505664846767e-07 6.515579063986723 0.13388215988850538 VLPSISLS(ph)PGPQPPK ddPTM_A459_Selumetinib_30min_R1 2 VLPSISLSPGPQPPK 15 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 1 VLPSIS(0.026)LS(0.974)PGPQPPK;VLPS(0.003)IS(0.185)LS(0.811)PGPQPPK 115.91 0.0023189 16463500.0 8908.8 10164.400000000001 6824.799999999999 6325.2 8226.0 7069.2 10325.8 9942.7 5125.1 9847.6 True False 9116.357706492805 8974.347322698643 5898.029645942952 5220.622558709142 7481.959752418259 6998.090266320042 9546.916592650725 9678.98729755876 8696.920377506205 11111.635383746945 0.8204334818101893 0.8076531503027424 0.5307976226946787 0.46983386139050043 0.6733446062640037 0.629798407222414 0.8591819532357097 0.8710677558513369 0.7826859033034185 1.0 13.439783544286417 -7.266588543868191 21.30764485246919 0.8674896931180144 0.6489641924192486 0.48394945067724215 0.11244071253359768 56.35414586700818 233190.42310062403 0.050019072467553986 0.03503778320645482 5.412668832534922e-08 7.266588543868191 -0.21852550069876575 VLPSISLS(ph)PGPQPPK ddPTM_A459_Selumetinib_30min_R2 2 VLPSISLSPGPQPPK 15 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 1 VLPS(0.008)IS(0.202)LS(0.791)PGPQPPK;VLPSIS(0.058)LS(0.942)PGPQPPK 134.02 0.00048692 13209100.0 75749.0 53365.0 69925.0 78836.0 82885.0 73523.0 93979.0 113814.0 90404.0 57658.0 True False 71539.1738272726 57457.92390447993 65426.1016285835 68098.40080031448 72472.24529869854 83650.12587465737 98349.2097158557 114145.17989707808 108487.32609881094 55993.263726525 1.277638934866789 1.0261577925714143 1.1684637985763633 1.2161891675561514 1.294302929949896 1.4939319537294773 1.7564471718633885 2.038552002515358 1.9375067441803462 1.0 15.772965653632214 -6.8883070158581985 1.8564826330368898 1.769465735073013 1.1661098862814736 0.4101397918266053 0.2706083320331217 0.28410373411957796 2.004899435401601 0.11304266114529242 0.09428913843625418 1.2932812587158103e-07 6.8883070158581985 -0.6033558487915394 VLS(ph)PEELEDR ddPTM_A459_Selumetinib_30min_R1 2 VLSPEELEDR 10 0 A0A494C179;A0A0A0MRH8;A0A494C1P7;A0A0A0MSH9;A0A494C1F7;Q86WJ1-5;Q86WJ1-3;Q86WJ1-4;Q86WJ1-2;Q86WJ1 A0A494C179 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 1 VLS(1)PEELEDR;VLS(1)PEELEDR 107.09 0.011501 9011400.0 2489.9 2831.8 3052.2 3534.6000000000004 3072.4 2767.0 2761.7 2549.3 1770.96 2156.12 True False 2547.909825497984 2500.2515395318974 2637.728004534505 2917.3484626594172 2794.5019624762785 2739.1664922349873 2553.3827455425735 2481.6842827065648 3005.189774199214 2432.8790043873087 1.0472817681862665 1.0276925136938964 1.0842002416798304 1.199134218100631 1.1486399271960672 1.1258950762842452 1.0495313334275793 1.020060709238414 1.2352401285801038 1.0 11.248448856434088 -5.516820084188648 24.85756426378934 1.113960214894458 1.042101932031487 0.14599548350881786 0.0703549161015331 455.86568488298303 1870332.6322851118 0.019013314548547006 0.0343801843992227 3.0421450385470784e-06 5.516820084188648 -0.07185828286297102 VLS(ph)PEELEDR ddPTM_A459_Selumetinib_30min_R2 2 VLSPEELEDR 10 0 A0A494C179;A0A0A0MRH8;A0A494C1P7;A0A0A0MSH9;A0A494C1F7;Q86WJ1-5;Q86WJ1-3;Q86WJ1-4;Q86WJ1-2;Q86WJ1 A0A494C179 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 1 VLS(1)PEELEDR;VLS(1)PEELEDR 110.08 0.0096793 5970000.0 24581.5 20196.0 25792.2 25980.0 29044.7 20756.6 19122.6 19850.7 14987.0 22149.6 True False 23215.358637541107 21744.968259624788 24132.75793242406 22441.479182000236 25395.84512308753 23615.633240345407 20011.838790713045 19908.462250539713 17984.81877176761 21510.083496427866 1.079277941501084 1.010919751345267 1.1219276734296144 1.043300421670936 1.1806483748566092 1.09788663741204 0.9303468670419791 0.9255409098642443 0.836111062737358 1.0 14.392725504480048 -7.286440688931169 5.809772797212884 0.9153799736132786 1.0892460414146015 0.6766438147080077 0.05615218420404095 0.10711505582072779 12.347657193590774 0.023404673468631135 0.016137264191591408 5.170818703885386e-08 7.286440688931169 0.17386606780132285 VLS(ph)PESLSCTEIPIPLNER ddPTM_A459_Selumetinib_30min_R1 2 VLSPESLSCTEIPIPLNER 19 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 VLS(0.915)PES(0.069)LS(0.011)CT(0.006)EIPIPLNER;VLS(0.922)PES(0.076)LS(0.001)CTEIPIPLNER 178.99 6.2212e-13 8688700.0 1427.38 1977.01 1813.05 1461.42 1740.8600000000001 1371.25 1566.37 1387.45 981.21 1296.28 True False 1460.6351768020063 1745.5407501129869 1566.8477683707752 1206.210431250983 1583.399520373796 1357.456469995383 1448.2174498082782 1350.6503189272444 1665.0417052570415 1462.670164836457 0.9986087170687056 1.1933932831043683 1.071224262338028 0.8246633179845102 1.0825403829515028 0.9280673815802909 0.9901189513701507 0.9234141444857203 1.138357604664215 1.0 10.514388760082793 -5.540088406019744 24.99861690563469 0.9800582118423551 1.105078007322662 0.21097151702764105 0.09233344686345606 288.6877211529352 419344.01643109444 0.02340159918499404 0.040544556387912954 2.8834444825503054e-06 5.540088406019744 0.12501979548030695 VLS(ph)PESLSCTEIPIPLNER ddPTM_A459_Selumetinib_30min_R2 2 VLSPESLSCTEIPIPLNER 19 0 Q9P266 Q9P266 KIAA1462 Junctional protein associated with coronary artery disease 1 VLS(0.948)PES(0.052)LSCTEIPIPLNER;VLS(0.994)PES(0.006)LSCTEIPIPLNER 251.04 9.5063e-38 4667400.0 19010.8 14164.9 18131.0 20430.3 20459.7 13993.8 13942.3 15150.6 18462.5 15208.1 True False 17954.255842262133 15251.302282667813 16964.471199540203 17647.657895766708 17889.369573961303 15921.318926931453 14590.644576143333 15194.685737683147 22155.51588535128 14769.00263761082 1.2156715170826586 1.0326562095553269 1.148653813381981 1.1949119604613712 1.2112781081373865 1.078022620592276 0.9879234863826702 1.02882273844195 1.5001362264591873 1.0 13.850284782608385 -6.781787065872613 24.62162802986415 1.112591365190407 1.1547632010253548 0.018505312499081605 0.14494317261483264 1218.0375432802236 1473869.03326916 0.051278111161031176 0.04528303983385317 1.6527719519525457e-07 6.781787065872613 0.04217183583494788 VLS(ph)PLIIK ddPTM_A459_Selumetinib_30min_R1 2 VLSPLIIK 8 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 VLS(1)PLIIK;VLS(1)PLIIK 105.2 0.014257 237970000.0 14557.1 17580.6 18736.1 19715.6 16185.5 14027.7 16198.699999999999 14910.4 8303.3 11970.0 True False 14896.252106814214 15522.255179000796 16191.840530030451 16272.640567647819 14721.524382782114 13886.594074132543 14976.819017351801 14514.927756195011 14090.093650962364 13506.466097673647 1.102897826795711 1.1492462252338789 1.1988213950960371 1.2048037177134452 1.0899612286679303 1.028144147677857 1.1088628890077625 1.074665101235849 1.0432109738452786 1.0 13.721362629321733 -6.439740737589749 5.169086215313292 1.0591157467878982 1.1647370844212905 0.6623661006667114 0.03783270826464013 0.14841607378989494 6.747878426673446 0.0123627238936283 0.01391737473219474 3.6329486755133236e-07 6.439740737589749 0.10562133763339232 VLS(ph)PLIIK ddPTM_A459_Selumetinib_30min_R2 2 VLSPLIIK 8 0 Q8NCN4 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 VLS(1)PLIIK;VLS(1)PLIIK 106.2 0.013829 133688000.0 170935.0 181397.0 187126.0 197547.0 191897.0 137666.0 156526.0 168010.0 139606.0 174623.0 True False 161435.11700702098 195309.5666167143 175086.51688738356 170640.7578124169 167789.18327905363 156628.24189247697 163804.76915038485 168498.88128444733 167531.1009175543 169581.18026495812 0.9519636362642981 1.1517172265905773 1.032464313633292 1.0062482024585704 0.989432807442992 0.9236180668618821 0.9659371924080958 0.9936178119599134 0.9879109265296967 1.0 17.371616546195554 -5.8938226805477125 2.2807100422677857 0.9737618662867833 1.0579553714004315 0.2753385766788573 0.04942558194628078 0.33424072232073077 3.533438046682249 0.01470917307564489 0.024716037295352225 1.2769600764124487e-06 5.8938226805477125 0.0841935051136482 VLS(ph)PLRS(ph)PPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R1 3 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VLS(1)PLRS(0.997)PPLIGS(0.002)ESAYESFLSADDK;VLS(0.991)PLRS(0.522)PPLIGS(0.483)ES(0.005)AYESFLSADDK;VLS(1)PLRS(0.987)PPLIGS(0.009)ES(0.004)AYESFLSADDK 119.69 1.5258e-08 217603200.0 4518.0 5835.6 4765.1 5584.6 4698.23 4706.1 4718.38 4218.46 2580.76 3822.27 True False 4623.260609502347 5152.36523910316 4118.025592820705 4609.354445925358 4273.275926039878 4658.760906796919 4362.468797810467 4106.572737310765 4379.3612287473225 4312.895586562662 1.071962099872453 1.1946417750422629 0.9548168997299407 1.0687377779991587 0.9908136750061318 1.0801932978187185 1.011494183026887 0.9521614087077088 1.0154109091793786 1.0 12.074441074100681 -5.262745904353251 24.999939899790927 1.0115815998121862 1.1333019376683238 0.5185835310957989 0.047783527726594624 83.88360684747 1605124.8181769706 0.011931553075984137 0.027243547078872846 5.460772648093765e-06 5.262745904353251 0.12172033785613756 VLS(ph)PLRS(ph)PPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R2 6 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VLS(0.989)PLRS(0.886)PPLIGS(0.072)ES(0.017)AY(0.03)ES(0.005)FLS(0.001)ADDK;VLS(1)PLRS(0.998)PPLIGS(0.002)ES(0.001)AYESFLSADDK;VLS(1)PLRS(0.997)PPLIGS(0.003)ESAYESFLSADDK;VLS(1)PLRS(0.999)PPLIGSESAYESFLSADDK;VLS(0.998)PLRS(0.976)PPLIGS(0.024)ES(0.001)AYESFLSADDK;VLS(0.937)PLRS(0.873)PPLIGS(0.117)ES(0.041)AY(0.028)ES(0.003)FLSADDK 100.14 6.5009000000000016e-06 40236600.0 114922.59999999999 104824.8 120331.09999999999 114231.2 116379.9 93411.2 100482.5 97106.2 97737.79999999999 108101.2 True False 108535.66196361835 112864.52509514338 112589.12803259546 98672.71350018893 101759.21651249331 106277.74489755328 105155.13535229633 97388.76296520322 117288.09102230394 104980.0374753516 1.0338695296151097 1.0751046371234436 1.0724813092111003 0.9399188252657694 0.9693196817193507 1.0123614684601954 1.0016679159310249 0.9276883996928393 1.1172418475259371 1.0 16.679755492105706 -5.737287566483327 24.998444861099703 0.9923179849985323 1.061947146770744 0.2629642390101721 0.049677131065613056 290.42404323502063 300602.26062562177 0.012955389650857515 0.02242520755081745 1.8311015637493542e-06 5.737287566483327 0.06962916177221168 VLS(ph)PLRS(ph)PPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 2 VLSPLRSPPLIGSESAYESFLSADDKASGR 30 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VLS(0.842)PLRS(0.436)PPLIGS(0.296)ES(0.412)AY(0.01)ES(0.003)FLSADDKASGR;VLS(0.997)PLRS(0.976)PPLIGS(0.024)ES(0.003)AYESFLSADDKASGR 74.277 0.00014121 62251000.0 2389.0 2101.08 5001.9 4802.299999999999 3790.6 3077.6000000000004 2954.0 2401.0 2105.83 1924.82 True False 2444.6590518152093 1855.0845768344088 4322.669453470001 3963.6684553356267 3447.7408992847845 3046.642138237224 2731.177401720956 2337.317680452855 3573.4397062621015 2171.8893963345186 1.1255909513352946 0.8541339996250367 1.9902806564484075 1.8249863285050705 1.5874385247718006 1.4027611826730308 1.2575121948338361 1.0761679137057016 1.645313850830972 1.0 11.084734920298553 -7.123861637710955 3.661919412152277 1.2515578380914767 1.4900311649612419 0.09242356645299021 0.34046969181855086 0.6959627674725187 16.74515196997581 0.1487866623112608 0.1133654556670017 7.518623924146682e-08 7.123861637710955 0.2384733268697652 VLS(ph)PLRS(ph)PPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R2 2 VLSPLRSPPLIGSESAYESFLSADDKASGR 30 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VLS(0.999)PLRS(0.989)PPLIGS(0.009)ES(0.002)AYESFLS(0.001)ADDKASGR;VLS(1)PLRS(1)PPLIGSESAYESFLSADDKASGR 73.21300000000002 0.00027738 7031200.0 17400.699999999997 23098.0 20844.0 28038.0 25679.0 11907.2 7824.5 10252.7 5702.9 23819.0 True False 16433.63875452114 24869.54232822407 19502.919733231265 24219.1760317522 22452.974446827295 13547.308717200343 8188.354753952616 10282.53365957414 6843.639352339598 23131.28358080575 0.7104507926294981 1.0751475265670394 0.8431404018328975 1.0470312184425934 0.9706756811999264 0.5856704263675989 0.3539948280581922 0.4445293156194128 0.2958607691800737 1.0 14.497557704506796 -6.8494856319767665 4.2720092203312845 0.47701373871658737 0.9395807906240383 0.47553455156401525 0.20429040091187853 0.1630652937743104 5.476811282698519 0.06922247740869122 0.06144806869140454 1.4142115114986832e-07 6.8494856319767665 0.46256705190745095 VLS(ph)PLRSPPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R1 2 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VLS(0.96)PLRS(0.04)PPLIGSESAYESFLSADDK;VLS(0.751)PLRS(0.248)PPLIGSESAYESFLSADDK 111.89 8.8449e-09 5922521000.0 4744.299999999999 5211.6 6067.599999999999 6530.7 5528.1 4901.8 4346.6 4591.299999999999 2722.1800000000003 3699.1000000000004 True False 4854.8329591992015 4601.42344919289 5243.653246941079 5390.235841421902 5028.084331065328 4852.492342478298 4018.732462532262 4469.523809355763 4619.340639839188 4173.915517285264 1.1631363737704037 1.1024237146480815 1.2562911791639657 1.2914099049440604 1.2046444903455111 1.1625756013467143 0.9628207485009342 1.070822777999772 1.1067163723629054 1.0 12.027185684386698 -7.083668042569906 5.360158270134632 1.0416412085875202 1.2040013932568172 0.6425467199019157 0.05959085057634507 0.16226137566681653 7.782079185814498 0.02503258055402805 0.01943868714229696 8.247682942234621e-08 7.083668042569906 0.16236018466929703 VLS(ph)PLRSPPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 2 VLSPLRSPPLIGSESAYESFLSADDKASGR 30 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VLS(0.478)PLRS(0.478)PPLIGS(0.027)ES(0.011)AY(0.005)ES(0.001)FLSADDKASGR;VLS(0.862)PLRS(0.134)PPLIGS(0.002)ES(0.002)AY(0.001)ESFLSADDKASGR 71.882 6.667e-05 65534000.0 1954.12 1112.87 5012.5 5374.0 3163.1 2484.0 1780.4 1737.49 1270.88 1054.73 True False 1999.6471939443848 982.5746630407729 4331.830031691632 4435.531782473743 2876.9981634906635 2459.013215291547 1646.102994591737 1691.4061210370803 2156.590538597313 1190.1148694402114 1.6802136039901336 0.8256132985742307 3.6398419538520463 3.726977871102529 2.4174121653012395 2.0661982119828326 1.3831463137386113 1.4212124934063373 1.8120860380575683 1.0 10.216885113299334 -7.050478276663011 2.8134813272056176 1.4382487586878863 2.498396135895216 0.27023497419252074 0.814123587998844 0.4378924297337336 6.875548284812487 0.3763219111932543 0.29310990070975146 8.902699680506757e-08 7.050478276663011 1.0601473772073298 VLS(ph)PPGRR ddPTM_A459_Selumetinib_30min_R1 1 VLSPPGRR 8 1 Q86VQ6;H0YBI6;H0YBQ0 Q86VQ6 TXNRD3 Thioredoxin reductase 3 1 VLS(1)PPGRR 70.399 0.036686 3436800.0 1240.1 1569.8 1608.2 1867.4 1597.0 1618.6 1672.6 1528.9 1113.1 1228.5 True False 1268.9919171854492 1386.0070862197797 1389.8152732102706 1541.293645439425 1452.5516319732503 1602.3183535712137 1546.4344353820143 1488.3486054328894 1888.849402392569 1386.1899416033475 0.9154531273814177 0.9998680877864715 1.0026153209586341 1.1118921001956454 1.0478734467609432 1.155915438051642 1.1156006756139918 1.0736974499406475 1.3626194691672746 1.0 10.436909239853033 -5.167841658751372 0.5635289633871676 1.150322014890544 0.8352031775972797 0.39262095463219704 0.09050394402077315 2.728538897632222 0.894234856787209 0.05094126794527475 0.5318812995455309 6.7945131146976365e-06 5.167841658751372 -0.3151188372932643 VLS(ph)PPGRR ddPTM_A459_Selumetinib_30min_R2 2 VLSPPGRR 8 1 Q86VQ6;H0YBI6;H0YBQ0 Q86VQ6 TXNRD3 Thioredoxin reductase 3 1 VLS(1)PPGRR;VLS(1)PPGRR 77.533 0.027292 6914100.0 21830.0 20179.0 22828.4 22603.3 22921.7 17272.3 15564.1 18503.6 14420.7 20885.0 True False 20616.775992413903 21726.664414288407 21359.645597682607 19524.69154713264 20042.07112340203 19651.402542671618 16287.861489679071 18557.442412564105 17305.242948023566 20281.995784253253 1.0165062754041478 1.0712291159806266 1.053133322030667 0.9626612565559954 0.98817055957395 0.9689087184373039 0.8030699573621256 0.9149712193004165 0.853231759443476 1.0 14.307912002619288 -6.5291147170217485 1.1363405165482556 0.8887824571001961 1.0440743491167155 0.5280630790110953 0.055245549367152626 0.34569033768299 0.9440431024910289 0.025461080624876536 0.028887297746972497 2.9572312234511103e-07 6.5291147170217485 0.15529189201651938 VLS(ph)PTAAKPSPFEGK ddPTM_A459_Selumetinib_30min_R1 1 VLSPTAAKPSPFEGK 15 1 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 1 VLS(0.907)PT(0.093)AAKPSPFEGK 180.7 9.6159e-05 48684000.0 2789.9 2920.8 3628.7 3192.8 3175.5 2855.2 2998.8 2528.5 1500.0 2089.6 True False 2854.8992417996033 2578.8313781569177 3135.942471022328 2635.237416278782 2888.276585680062 2826.479280314178 2772.598101652268 2461.4359662744855 2545.3904443346087 2357.820514427639 1.2108212751268856 1.0937352365783997 1.3300174681801757 1.1176581932991136 1.2249772906828709 1.1987677870384066 1.1759156749576913 1.0439454365643261 1.0795522512248996 1.0 11.203238184149937 -7.728831088259038 4.459689188968768 1.0444199499835232 1.1945355604107848 0.5557673456552407 0.062395468844696926 0.1485185090335886 6.659685983296643 0.03091360628934796 0.016147808892532763 1.8671057298941105e-08 7.728831088259038 0.15011561042726163 VLS(ph)STSEEDEPGVVK ddPTM_A459_Selumetinib_30min_R2 1 VLSSTSEEDEPGVVK 15 0 Q8NI08-2;Q8NI08;Q8NI08-7;Q8NI08-4;Q8NI08-3 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 VLS(0.989)S(0.011)TSEEDEPGVVK 111.81 0.0031633000000000004 4136800.0 23014.0 17620.0 24858.0 26049.0 29849.0 19205.0 28459.0 29761.0 17235.0 18541.0 True False 21734.974012341438 18971.397342770288 23258.66334334402 22501.08126296859 26099.101766554308 21850.314424367836 29782.399890438668 29847.59958280123 20682.481586135622 18005.673154696662 1.2071181024782742 1.0536344395333936 1.2917408387632066 1.2496662062922834 1.4494932537274525 1.2135238842024811 1.6540564540165568 1.6576775178780627 1.148664724081184 1.0 14.136163916250023 -5.767697151933571 1.3287182493127407 1.3971995287949075 1.1308694246552817 0.11032295691134708 0.20391788257198973 0.7739320125379343 2.7235272537941793 0.06910628857634324 0.16941023819695775 1.7072725122179661e-06 5.767697151933571 -0.26633010413962577 VLS(ph)TSTDLEAAVADALKKPVR ddPTM_A459_Selumetinib_30min_R1 1 VLSTSTDLEAAVADALKKPVR 21 2 Q7Z460 Q7Z460 CLASP1 CLIP-associating protein 1 1 VLS(0.25)T(0.25)S(0.25)T(0.25)DLEAAVADALKKPVR 124.08 2.7981e-05 31142000.0 2469.3 2171.6 4688.3 4539.0 3942.7 2231.3 2498.5 2751.4 1671.9 1942.5 True False 2526.8298855786065 1917.3480624505494 4051.654610988507 3746.3488575824954 3586.0834811402196 2208.8551478583026 2310.036133446109 2678.4239341932453 2837.0921892553565 2191.838796552302 1.152835641723851 0.8747669150972606 1.8485185212350657 1.7092264556478296 1.6361073117151788 1.0077635049314606 1.0539261085622391 1.2219985969800002 1.294389073556878 1.0 11.097925980785941 -6.7688826430864655 24.999748429788507 1.1256347721681401 1.4498264751565353 0.2636556487110544 0.27430373280235665 280.22965612064746 941203.9692248784 0.10656372662082089 0.09582745628049515 1.70261853510415e-07 6.7688826430864655 0.32419170298839517 VLSANHGDPSIQTSGSEQT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 VLSANHGDPSIQTSGSEQTSPK 22 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 VLSANHGDPSIQTS(0.145)GS(0.006)EQT(0.544)S(0.305)PK 165.32 1.7617000000000003e-11 8367700.0 1977.1 2052.1 2094.5 2718.2 2826.6 2338.9 2618.3 1977.9 744.17 1311.5 True False 2023.162583233088 1811.839178004591 1810.0784042649632 2243.517396933408 2570.934529076762 2315.3727895512875 2420.7995229945777 1925.4396668753436 1262.8021379736572 1479.843800091812 1.3671460346744486 1.2243448787582727 1.223155041196012 1.5160501377200866 1.7373012806603352 1.56460620330851 1.635848001555561 1.3011100676678755 0.8533347491777922 1.0 10.531229189755853 -8.11474109851224 4.072673377814581 0.9336418783167493 1.4648091387984021 0.6384135489583831 0.16005576980083022 0.16959993625308695 4.6464044410316925 0.13835797536897726 0.04813097925935677 7.678190826986869e-09 8.11474109851224 0.5311672604816529 VLSANHGDPSIQTSGSEQT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 2 VLSANHGDPSIQTSGSEQTSPK 22 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 VLSANHGDPSIQT(0.002)S(0.043)GS(0.017)EQT(0.469)S(0.469)PK;VLSANHGDPS(0.015)IQT(0.083)S(0.067)GS(0.054)EQT(0.442)S(0.34)PK 156.58 8.343399999999999e-09 36923000.0 68702.0 56601.0 85302.0 102933.0 116322.0 79503.0 80583.0 85195.0 75023.0 107029.0 True False 64883.81787589648 60942.114699099904 79813.76218979512 88913.3478306709 101708.59042812584 90453.81659362224 84330.26917218516 85442.90334520854 90029.69631776339 103938.794675262 0.6242502434111753 0.5863269329753393 0.7678919352409156 0.8554394738602136 0.9785431007343885 0.8702603958053281 0.811345459947461 0.8220501653127638 0.8661799148147226 1.0 16.66537470845997 -5.477781446053742 2.478145367895956 0.8793513807351168 0.6018672738666776 0.7837543181130069 0.05866188975964267 0.13528023482342183 1.6236288659659202 0.017212210974120148 0.04203513721446452 3.328270027044695e-06 5.477781446053742 -0.27748410686843916 VLSANHGDPSIQTSGSEQTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 VLSANHGDPSIQTSGSEQTSPK 22 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 VLSANHGDPSIQTSGSEQT(0.242)S(0.757)PK;VLSANHGDPSIQTS(0.001)GS(0.001)EQT(0.24)S(0.759)PK 202.15 9.800599999999999e-23 61471000.0 9523.6 10175.7 10741.099999999999 11882.8 12632.900000000001 10540.400000000001 13115.9 9018.7 2648.1 6157.9 True False 9745.481350300255 8984.324313445413 9282.517616638997 9807.692047781731 11490.256425519641 10434.373145917478 12126.557103328336 8779.494779133762 4493.632290428318 6948.3264480254375 1.4025652685143641 1.2930198920055866 1.3359357373424627 1.4115186039609384 1.653672508260593 1.501710264186378 1.7452486140420818 1.2635409180621764 0.646721526980833 1.0 12.762449821364932 -8.077469426559178 4.953903176374943 0.8398861135554626 1.472903642837476 0.7408866776754747 0.15270677177586334 0.11534411139896009 5.002789799543139 0.11317932291393423 0.04142812386062719 8.366244903310252e-09 8.077469426559178 0.6330175292820134 VLSANHGDPSIQTSGSEQTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 VLSANHGDPSIQTSGSEQTSPK 22 0 Q9H694;Q9H694-2;A6NGY7 Q9H694 BICC1 Protein bicaudal C homolog 1 1 VLSANHGDPSIQTS(0.002)GSEQT(0.249)S(0.749)PK;VLSANHGDPSIQTS(0.002)GS(0.001)EQT(0.242)S(0.755)PK 158.12 3.3544000000000003e-09 84564000.0 307350.0 243402.0 357900.0 504570.0 525640.0 350970.0 305410.0 370700.0 347100.0 460360.0 True False 290268.71741953364 262070.15073921526 334873.1036520565 435846.6955682014 459604.40391877835 399312.931711553 319612.1701584341 371778.67562731134 416529.69878431555 447068.2106410735 0.6492716558918442 0.5861972390374608 0.749042530158575 0.9748997696419054 1.028040896174945 0.8931812242676753 0.7149069483158423 0.8315927341248425 0.9316916051513319 1.0 18.77013543928183 -5.532687421602157 4.168366095355038 0.8989853501968795 0.6238753033970907 0.651836588983532 0.0865206188397121 0.13956701663642598 5.702406765855303 0.026454961728680747 0.05180114349015108 2.9330034808635027e-06 5.532687421602157 -0.2751100467997888 VLSAPPHFHFGQTNR ddPTM_A459_Selumetinib_30min_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 104.7 0.0027715 6295900.0 2796.3 4153.5 3812.8 3609.9 3506.3 3934.6 3544.2 2970.3 1518.8 2047.8 False True 2861.4483493473695 3667.206289090235 3295.0427022112435 2979.498731215478 3189.1557840875425 3895.021496330964 3276.8581405482087 2891.5179951058353 2577.292671236937 2310.6550772611595 1.2383710478930807 1.5870851193580169 1.4260210165668203 1.2894606211616426 1.38019551921513 1.685678461775337 1.4181511437147505 1.251384520156586 1.115394805827889 1.0 11.174086202423528 -8.115312391739943 1.9165335299767638 1.024648132532054 1.4400678564157021 0.5993097383696175 0.12379072128013002 0.24186533099680416 1.5813648342020408 0.11374730719579419 0.03542489049424468 7.668097181418419e-09 8.115312391739943 0.4154197238836481 VLSEDEEDVDFDIIHNANDTFTVK ddPTM_A459_Selumetinib_30min_R1 1 VLSEDEEDVDFDIIHNANDTFTVK 24 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 158.02 1.3905e-11 0.0 467.69 806.45 487.84 529.37 621.74 670.12 827.34 430.64 316.1 452.81 False True 478.5862670336773 712.0304590915663 421.59400751330566 436.92546700560604 565.5037267771122 663.3792012202782 764.9330777047447 419.21802828413854 536.3986129694466 510.93257424290766 0.9366916324386625 1.3935898687740598 0.8251460736047558 0.8551528891126892 1.1068069551350632 1.298369363517806 1.4971311602870716 0.8204957941961905 1.0498422688439353 1.0 8.996989106723161 -3.9751937065543896 17.894427758808643 1.087399189694138 1.0495587868603826 0.0 0.23070164007213548 0.0 0.0 0.05452087964769538 0.0 0.00010587813760089004 3.9751937065543896 -0.03784040283375534 VLSKPPEGVVSEVEMLS(ph)SQER ddPTM_A459_Selumetinib_30min_R1 1 VLSKPPEGVVSEVEMLSSQER 21 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 VLSKPPEGVVSEVEMLS(0.917)S(0.083)QER 162.98 2.6238e-08 3458000.0 1392.2 1493.1 1889.9 1746.9 1719.4 1291.9 1842.7 1610.8 850.87 1402.4 True False 1424.6355512503685 1318.287157876641 1633.2619604776085 1441.8367083742812 1563.8805735847257 1278.9046589513487 1703.7036554337199 1568.0763513841976 1443.8642449139923 1582.4117005327912 0.9002938683850099 0.8330873422085917 1.0321346587159943 0.9111640844723412 0.9882893137469685 0.8081996982964338 1.0766500619655999 0.9909408220731893 0.9124453796871252 1.0 10.627909283363044 -1.522878745320314 0.31418074377766253 0.978339544761187 7.615734578443083e-09 0.12699544968237741 0.076693201950138 116.64955422746104 1.6656331385970513 0.07298335493759545 65.16172774341631 0.02999999999723852 1.522878745320314 -0.9783395371454524 VLSKPPEGVVSEVEMLS(ph)SQER ddPTM_A459_Selumetinib_30min_R2 2 VLSKPPEGVVSEVEMLSSQER 21 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 VLS(0.017)KPPEGVVS(0.293)EVEMLS(0.396)S(0.293)QER;VLSKPPEGVVS(0.098)EVEMLS(0.521)S(0.381)QER 50.536 0.032909 11404200.0 31301.0 33076.0 34095.0 34295.0 38028.0 27300.0 26273.0 24302.0 20559.0 30130.0 True False 29561.415727830867 35612.82284389725 31901.36481982919 29623.961837825173 33250.58266536655 31060.327195274254 27494.746558961862 24372.714796587337 24671.374466455603 29260.068612858544 1.0102989203121655 1.2171134427294865 1.0902696518561787 1.0124365130438113 1.1363808849974586 1.0615261230667303 0.9396678771586715 0.8329684772467203 0.8431755507098706 1.0 14.836645532050959 -7.313645743824996 2.7972246157149763 0.8793366177652424 1.0957359713708652 0.6261437107837835 0.070248141826201 0.16635265664211832 2.5742531214274513 0.0321377518388834 0.020870230421037774 4.8568451390539406e-08 7.313645743824996 0.2163993536056228 VLSKPPEGVVSEVEMLSS(ph)QER ddPTM_A459_Selumetinib_30min_R1 1 VLSKPPEGVVSEVEMLSSQER 21 1 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 VLSKPPEGVVSEVEMLS(0.269)S(0.731)QER 94.72 0.00024057 3487600.0 1504.1 1544.3 1893.2 1695.7 2060.7 1395.9 1540.2 1390.6 1053.4 1291.3 True False 1539.142603530873 1363.4926380744078 1636.1138386032121 1399.5778272312477 1874.3100488461337 1381.8585133757922 1424.0214739778658 1353.7167706946025 1787.5428627080507 1457.05093332715 1.0563409749968506 0.9357892760556397 1.1228940603106956 0.9605551839120247 1.2863723607562434 0.9483941033003855 0.977331293921303 0.9290799242023847 1.226822495920735 1.0 10.50883559444211 -5.254737102319086 24.89223523319865 1.0520028974387217 0.9960651417310774 0.038875245107166556 0.11843585974251732 2072.103170900774 7695739.998130594 0.02954074386998572 0.0745363264353584 5.5624087260716175e-06 5.254737102319086 -0.055937755707644254 VLSPLRS(ph)PPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R1 3 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VLS(0.158)PLRS(0.816)PPLIGS(0.006)ES(0.006)AY(0.012)ESFLSADDK;VLS(0.019)PLRS(0.37)PPLIGS(0.004)ES(0.215)AY(0.347)ES(0.016)FLS(0.028)ADDK;VLS(0.404)PLRS(0.581)PPLIGS(0.011)ES(0.003)AYESFLSADDK 106.58 1.7635000000000002e-08 27577100.0 4107.91 4897.79 4574.14 4796.92 3838.35 4158.87 4313.46 4235.88 2254.4100000000003 3710.18 True False 4203.616310398581 4324.354469879204 3952.996911952511 3959.2279713405223 3491.1719202157337 4117.035543751833 3988.092239413433 4123.530702322629 3825.5691144082575 4186.417743213601 1.0041081822789566 1.032948629383488 0.9442433016534297 0.9457317005114062 0.8339282255993452 0.9834268332217346 0.9526264419928795 0.9849783168454903 0.9138049160549498 1.0 12.031500563286885 -5.269568942581006 23.60529992744672 0.9420325194322127 1.0185284077144852 0.3018384724015962 0.044663278496099926 294.87517018624584 856215.7681435575 0.01172985940790921 0.025184332462573695 5.375650899550813e-06 5.269568942581006 0.0764958882822725 VLSPLRS(ph)PPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R2 2 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VLS(0.091)PLRS(0.9)PPLIGS(0.005)ESAY(0.003)ES(0.001)FLSADDK;VLS(0.008)PLRS(0.992)PPLIGSESAYESFLSADDK 91.503 1.7567e-05 60983600.0 36439.0 32672.0 37172.0 38210.0 38019.0 29905.0 33052.0 37623.0 37917.0 37331.0 True False 34413.86625687448 35177.83734296202 34780.39398981349 33005.732084073476 33242.71332582758 34024.142299438674 34588.98349129551 37732.47670117708 45501.45948949842 36253.15703241362 0.9492653626304973 0.9703385917951872 0.9593755919992474 0.9104236647463102 0.9169605090145824 0.9385152931375879 0.9540957622082351 1.0408052646957289 1.255103367930577 1.0 15.145819014309732 -7.9354832316742066 3.6875391024795285 1.134195505396249 0.9422711325756968 0.6033465668659999 0.060260468231920675 0.1328941154269299 3.5894383456984937 0.03582582549170365 0.015061932604521242 1.160157009522044e-08 7.9354832316742066 -0.19192437282055208 VLSPLRS(ph)PPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 4 VLSPLRSPPLIGSESAYESFLSADDKASGR 30 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VLS(0.01)PLRS(0.961)PPLIGS(0.023)ES(0.006)AYESFLSADDKASGR;VLS(0.052)PLRS(0.948)PPLIGSESAYESFLSADDKASGR;VLS(0.017)PLRS(0.842)PPLIGS(0.035)ES(0.074)AY(0.031)ES(0.001)FLSADDKASGR;VLS(0.025)PLRS(0.973)PPLIGS(0.002)ESAYESFLSADDKASGR 128.19 3.193e-18 1499757000.0 6829.7 5799.7699999999995 15799.65 16927.929999999997 10744.82 8841.16 7461.950000000001 7042.650000000001 5116.11 5489.700000000001 True False 6988.818721717174 5120.730232160079 13654.144311265183 13971.784802100996 9772.952928152048 8752.225957530998 6899.089103849588 6855.85604424877 8681.665004109824 6194.356469206265 1.128255817446152 0.8266767109087995 2.2042877866560375 2.2555668004510756 1.5777188440374565 1.4129354681217587 1.113770112867532 1.1067906857364425 1.4015443004077353 1.0 12.596738693434784 -7.001355785562854 2.9963378630567172 1.1668745852377689 1.623824350265529 0.20146101381322767 0.41348131055262016 0.49108976201081445 9.005631731385428 0.18565384171763216 0.15004421279385 9.96883056160835e-08 7.001355785562854 0.4569497650277601 VLSPLRSPPLIGSES(ph)AYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 1 VLSPLRSPPLIGSESAYESFLSADDKASGR 30 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VLS(0.017)PLRS(0.33)PPLIGS(0.195)ES(0.455)AY(0.002)ESFLSADDKASGR 59.083 0.00128 1824900.0 201.15 169.27 388.58 449.47 421.95 345.46 402.21 325.63 0.0 164.76 True False 205.836403630234 149.4517897085119 335.8129703171539 370.9785020968506 383.7846970013232 341.9849860525837 371.8709758788712 316.99323460469077 0.0 185.90855089830484 1.1071916952482193 0.8038994924459639 1.8063341825565051 1.9954891816664324 2.0643735597253943 1.83953338563569 2.000289788081297 1.7051030362669628 0.0 1.0 7.538449318584401 -5.260539237915994 24.932280597924468 1.6370770882260859 0.9555455671548879 0.12247716658445773 0.6040787064831857 134.22922909853938 3717757.631076107 0.1582170646809241 0.3723084458358396 5.488589647055843e-06 5.260539237915994 -0.681531521071198 VLSPLRSPPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R1 1 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 100.92 4.6996e-06 3911600.0 1534.5 2000.8 1373.3 1562.6 1691.8 1450.7 1776.2 1490.9 1048.3 1548.7 False True 1570.25086438277 1766.5454058533144 1186.8134029969315 1289.7212436348107 1538.7769887115496 1436.1072751302106 1642.2198039731768 1451.3564888742853 1778.8885351973124 1747.4907306154707 0.8985746458464611 1.0109040207790587 0.6791529031910417 0.7380418225054433 0.8805637487814246 0.8218110974611064 0.9397588068434461 0.8305374463205958 1.0179673654525099 1.0 10.771069087655897 -8.179699390378076 1.2284919752549333 1.0142059855827497 0.8403145965540618 0.29304672293108003 0.09240502377247134 0.6144963338657435 1.7675038141113706 0.09070706910886478 0.029714493091350717 6.611509246021481e-09 8.179699390378076 -0.17389138902868784 VLSPLRSPPLIGSESAYESFLSADDK ddPTM_A459_Selumetinib_30min_R2 1 VLSPLRSPPLIGSESAYESFLSADDK 26 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 92.886 0.0008326000000000001 0.0 0.0 0.0 657.94 670.76 0.0 490.84 0.0 608.76 0.0 722.63 False True 0.0 0.0 615.6088567109083 579.4013308744601 0.0 558.4487545981101 0.0 610.5313908143567 0.0 701.7657942817781 0.0 0.0 0.8772283598418371 0.8256334742952927 0.0 0.7957765384812667 0.0 0.8699930885619821 0.0 1.0 9.454845818873157 -11.953233434423037 2.332371309382765 7.089879790722069 0.396309586108595 0.18004260810627226 0.3981027841668738 21316481.261582576 1678052.8872119638 688315415.179195 0.09710371956902995 1.1136957582935525e-12 11.953233434423037 -6.693570204613474 VLSPLRSPPLIGSESAYESFLSADDKASGR ddPTM_A459_Selumetinib_30min_R1 1 VLSPLRSPPLIGSESAYESFLSADDKASGR 30 2 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 0 135.68 3.9031999999999986e-18 4651700.0 475.79 343.08 580.54 633.37 474.17 289.75 211.11 201.93 216.13 151.3 False True 486.8749812738206 302.91203410643516 501.7058566779569 522.7638193273904 431.28140722151284 286.83537807195063 195.1858027343639 196.5741604389192 366.75682448935953 170.72082878680223 2.851878032304041 1.7743121109417441 2.9387501234807845 3.062097478335363 2.5262377782859824 1.6801428396891942 1.1433039783219057 1.1514363059026784 2.1482839973051493 1.0 7.415495274820244 -6.819236885156236 3.4753848440719652 1.3781738332417914 2.635668721629194 0.6604853721834889 0.43733931874660115 0.1529352656732915 3.7443155899437848 0.16316012403385655 0.14694419036413836 1.5162231206530042e-07 6.819236885156236 1.2574948883874026 VLSQSTPGT(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 VLSQSTPGTPSK 12 0 Q6MZP7-3;Q6MZP7 Q6MZP7-3 LIN54 Protein lin-54 homolog 1 VLSQST(0.007)PGT(0.962)PS(0.03)K;VLSQS(0.001)TPGT(0.945)PS(0.054)K 173.33 0.00044 33830000.0 7343.8 9259.4 10063.0 9381.2 8206.5 7896.1 8701.3 7563.099999999999 4600.3 6940.7 True False 7514.896251452711 8175.305143421727 8696.499872102326 7742.949526933886 7464.223523975253 7816.672403085174 8044.953935543176 7362.502019588912 7806.373107381665 7831.606453143144 0.959559995310627 1.0438861033601405 1.11043627180884 0.9886795989124714 0.9530897100912872 0.9980931051442228 1.0272418543598303 0.9401011227567543 0.9967780115213334 1.0 12.93509255440911 -5.9573858143548355 24.99886239056103 0.9842324586861484 1.0403875013615345 0.24916274076519385 0.0410091863935887 185.84619146372782 109022.26555153317 0.011694157339773317 0.017345227915849654 1.1030982246981428e-06 5.9573858143548355 0.05615504267538607 VLSQSTPGT(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 VLSQSTPGTPSK 12 0 Q6MZP7-3;Q6MZP7 Q6MZP7-3 LIN54 Protein lin-54 homolog 1 VLSQS(0.005)T(0.005)PGT(0.978)PS(0.012)K 171.81 7.2699e-08 0.0 69456.0 65083.0 63858.0 74993.0 73763.0 54627.0 58358.0 55451.0 44338.0 64719.0 True False 65595.91357439762 70074.65682517135 59749.445803333365 64778.82402985924 64496.2324904133 62151.37339546692 61071.76263418321 55612.35322959276 53206.838907228404 62850.394309843716 1.0436834055649495 1.1149437898466161 0.9506614311562931 1.0306828579389435 1.0261866007149585 0.9888780186337301 0.9717005486569885 0.884836982174393 0.8465633269526692 1.0 15.939634175381734 -7.338633531791851 1.6180349719820766 0.9009443653286335 1.0326589520290854 0.48696165332512276 0.05307106182545406 0.31428365486759885 1.5988574286768455 0.031172587570402973 0.017691147800258603 4.585286410941697e-08 7.338633531791851 0.13171458670045189 VLSSAAS(ph)LPGSELPSSRPEGSQGGELSR ddPTM_A459_Selumetinib_30min_R1 1 VLSSAASLPGSELPSSRPEGSQGGELSR 28 1 O15027;O15027-5;A0A0C4DH09;Q8N9G1 O15027 SEC16A Protein transport protein Sec16A 1 VLS(0.005)S(0.015)AAS(0.541)LPGS(0.271)ELPS(0.074)S(0.074)RPEGS(0.02)QGGELS(0.001)R 53.987 0.0051887 9748300.0 443.12 532.3 643.85 619.31 582.75 496.88 365.97 443.53 218.84 449.29 True False 453.4438338385744 469.97806854044364 556.4187064148941 511.15913438850265 530.0403653928691 491.8818383309435 338.36458825586254 431.76614361151803 371.3554965587904 506.9607479552038 0.8944357835740011 0.9270502113547694 1.0975577668669145 1.0082814822453865 1.0455254524748823 0.9702562581322515 0.6674374487978332 0.8516756876208291 0.7325133120397009 1.0 8.985730238931172 -7.109120322109667 7.40364468138451 0.801134528532555 0.9982990926818032 0.4487536601678239 0.09632265488649235 0.22735203725794131 13.732099615204811 0.035734920674142745 0.027674652339723896 7.77821024395533e-08 7.109120322109667 0.1971645641492482 VLSSAAS(ph)LPGSELPSSRPEGSQGGELSR ddPTM_A459_Selumetinib_30min_R2 1 VLSSAASLPGSELPSSRPEGSQGGELSR 28 1 O15027;O15027-5;A0A0C4DH09;Q8N9G1 O15027 SEC16A Protein transport protein Sec16A 1 VLS(0.021)S(0.046)AAS(0.658)LPGS(0.112)ELPS(0.061)S(0.061)RPEGS(0.035)QGGELS(0.005)R 43.312 0.034988 23872000.0 15018.0 15757.0 15444.0 15769.0 16836.0 10671.0 11424.0 13093.0 8789.9 12015.0 True False 14183.359681817314 16965.51123325944 14450.349854155793 13621.234996957717 14720.911164250327 12140.833388306639 11955.238636226544 13131.098462337166 10548.125610326293 11668.095731280959 1.2155676477519115 1.454008573804949 1.2384497168133355 1.1673914330716875 1.2616378459070305 1.0405154078191456 1.0246092345793654 1.1253848755400633 0.9040143184673964 1.0 13.510281507586361 -6.523868121249154 0.66147611999728 0.9863143548811469 1.3431738303343885 0.677891443914473 0.08572869330348148 0.4547823391711427 0.4411401781357838 0.059626587901028434 0.08154599434963081 2.9931734117825395e-07 6.523868121249154 0.3568594754532416 VLSSAASLPGSELPS(ph)SRPEGSQGGELSR ddPTM_A459_Selumetinib_30min_R2 1 VLSSAASLPGSELPSSRPEGSQGGELSR 28 1 O15027;O15027-5;A0A0C4DH09;Q8N9G1 O15027 SEC16A Protein transport protein Sec16A 1 VLSSAAS(0.002)LPGS(0.04)ELPS(0.446)S(0.446)RPEGS(0.036)QGGELS(0.03)R 44.158 0.031595 5487300.0 5767.7 7185.5 6873.5 7906.6 6533.7 5504.8 5026.7 3826.1 5402.7 5040.4 True False 5447.154323932464 7736.60474497593 6431.266493300955 6829.707440354232 5712.878193980896 6263.03623240094 5260.451510217087 3837.2333175550452 6483.390964050769 4894.870555468041 1.1128290855102325 1.580553491109872 1.3138787676655947 1.395278457920566 1.1671152749073337 1.2795100833472555 1.0746865418822276 0.7839294776178477 1.3245275621861334 1.0 12.257054993019436 -6.930113555743495 1.3068138753795249 1.0268413161973062 1.3575527622211891 0.3584290049077591 0.17088253637539674 0.43676062829631657 1.5396713935942177 0.08615512425642637 0.06672066532835262 1.1745903925643336e-07 6.930113555743495 0.3307114460238829 VLSSAASLPGSELPSSRPEGS(ph)QGGELSR ddPTM_A459_Selumetinib_30min_R1 2 VLSSAASLPGSELPSSRPEGSQGGELSR 28 1 O15027;O15027-5;A0A0C4DH09;Q8N9G1 O15027 SEC16A Protein transport protein Sec16A 1 VLS(0.001)S(0.003)AAS(0.104)LPGS(0.039)ELPS(0.256)S(0.256)RPEGS(0.334)QGGELS(0.007)R;VLSSAASLPGS(0.001)ELPS(0.105)S(0.105)RPEGS(0.476)QGGELS(0.313)R 55.09 0.0046835 40628000.0 1560.8000000000002 1487.01 1769.37 2094.25 1634.48 1801.58 1486.06 1537.5 729.54 1452.3899999999999 True False 1597.163603211879 1312.9101779078062 1529.0992724537102 1728.528551441318 1486.6415725908823 1783.4577409037602 1373.9652977662304 1496.7205054961535 1237.9760965065802 1638.8184039766265 0.9745824182449555 0.8011321905599808 0.9330498539333701 1.0547407493392849 0.9071423465733092 1.088258306457972 0.8383877642771618 0.9132924684420985 0.7554077337077774 1.0 10.678440284189671 -10.641669273299653 4.673554195190539 1.0000059703975106 0.9215877992402945 0.05688489864299684 0.09888057024379036 6.140751410784435e-06 1.1579426007042307e-06 0.0955772847244099 0.023179131833183632 2.2820792739996464e-11 10.641669273299653 -0.07841817115721605 VLSSAASLPGSELPSSRPEGSQGGELS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 VLSSAASLPGSELPSSRPEGSQGGELSR 28 1 O15027;O15027-5;A0A0C4DH09;Q8N9G1 O15027 SEC16A Protein transport protein Sec16A 1 VLSSAASLPGS(0.001)ELPS(0.209)S(0.209)RPEGS(0.137)QGGELS(0.443)R 48.798 0.019001 9796700.0 13734.0 9632.6 9281.7 10843.0 12264.0 10362.0 9515.3 9333.2 6642.2 8826.3 True False 12970.719261558062 10371.38944630926 8684.52552715086 9366.164694781695 10723.286678448922 11789.271443129366 9957.780304209255 9360.35806680556 7970.825598574414 8571.461785518526 1.5132447167263905 1.209990746716238 1.0131907187433717 1.0927149801456058 1.251045264713879 1.3754096720173594 1.1617365337885437 1.0920375428401108 0.9299260497248104 1.0 13.065325548612504 -1.5228787452827715 0.11772353087627946 0.9163920089818132 2.168267106643065 0.3444284398485816 0.13813262351350591 145.92596693022753 1.1896640917954173 1.143399688361908 29.87551979498155 0.029999999999831873 1.5228787452827715 1.251875097661252 VLSST(ph)SEEDEPGVVK ddPTM_A459_Selumetinib_30min_R1 2 VLSSTSEEDEPGVVK 15 0 Q8NI08-2;Q8NI08;Q8NI08-7;Q8NI08-4;Q8NI08-3 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 VLSST(0.5)S(0.5)EEDEPGVVK;VLSS(0.001)T(0.5)S(0.5)EEDEPGVVK 311.95 2.8134999999999996e-94 53945000.0 6335.7 7880.3 7876.5 8352.1 7491.9 6541.0 6517.9 6698.0 3521.0 5707.4 True False 6483.309482873846 6957.670812547921 6806.914562517535 6893.562523334377 6814.25896780238 6475.203478752819 6026.249555408604 6520.347281829748 5974.879836334775 6440.0003847838425 1.0067250148295537 1.080383601992821 1.0569742477967272 1.0704288992935764 1.058114683331824 1.0054663186126749 0.9357529806437851 1.0124762255039217 0.9277763166679253 1.0 12.652845059201626 -6.919865792521813 3.605892726589121 0.969797879131178 1.0569438120771104 0.6432213639842772 0.030011583042131165 0.13756157540572356 3.544653918286537 0.010501410314004185 0.009048408808689862 1.2026360207603263e-07 6.919865792521813 0.08714593294593243 VLSST(ph)SEEDEPGVVK ddPTM_A459_Selumetinib_30min_R2 1 VLSSTSEEDEPGVVK 15 0 Q8NI08-2;Q8NI08;Q8NI08-7;Q8NI08-4;Q8NI08-3 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 VLS(0.192)S(0.192)T(0.588)S(0.028)EEDEPGVVK 209.53 3.2276e-06 4174800.0 27447.0 18928.0 22847.0 29372.0 26471.0 16421.0 20456.0 23901.0 19605.0 27304.0 True False 25921.60561904645 20379.716736887403 21377.048893932762 25371.482930473852 23145.47632625744 18682.843695003594 21407.24453279503 23970.547952976453 23526.54780946848 26515.66257568832 0.9775959980277262 0.768591645738212 0.8062045906985161 0.9568489136581659 0.8728982826730894 0.7045965244758213 0.8073433757006285 0.9040146699918624 0.8872698444669266 1.0 14.694557178667997 -8.610424633197901 1.4167797199561072 0.9977116190570482 0.8411546040392888 0.25152531418491475 0.07886564042763611 0.7535961267492507 3.2397920244624956 0.07738966838798315 0.022991230937555517 2.4523099870206757e-09 8.610424633197901 -0.15655701501775943 VLSSTINNQAVETDEGIEEEIPDS(ph)PGIEK ddPTM_A459_Selumetinib_30min_R1 2 VLSSTINNQAVETDEGIEEEIPDSPGIEK 29 0 Q1RLN5;Q8IWW6-3;Q8IWW6-2;Q8IWW6-4;Q8IWW6 Q1RLN5 ARHGAP12 Rho GTPase-activating protein 12 1 VLSSTINNQAVET(0.001)DEGIEEEIPDS(0.999)PGIEK;VLSSTINNQAVETDEGIEEEIPDS(1)PGIEK 132.33 6.3223e-14 8014300.0 2070.3 1961.93 2153.1000000000004 1901.02 2264.4 1900.3 1772.73 1549.88 1052.65 1551.4099999999999 True False 2118.533961897457 1732.2263235234884 1860.720846131721 1569.0425435649859 2059.5854198122897 1881.18470733435 1639.0115488668894 1508.7721476802458 1786.2701674858838 1750.5485855131055 1.21021146138397 0.9895334170435226 1.0629358485279188 0.8963147647256428 1.1765371363335237 1.0746258189588913 0.9362845238519767 0.8618853313562889 1.0204059357554522 1.0 10.773591388191484 -7.2632580074955495 24.793993087648893 0.943134386174769 1.0616271157958979 0.2650546442188607 0.09155921357062044 197.54940393789877 2693217.9858961715 0.03641732827401346 0.026012341962356657 5.454337312515469e-08 7.2632580074955495 0.11849272962112889 VLSSTS(ph)EEDEPGVVK ddPTM_A459_Selumetinib_30min_R1 1 VLSSTSEEDEPGVVK 15 0 Q8NI08-2;Q8NI08;Q8NI08-7;Q8NI08-4;Q8NI08-3 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 VLS(0.002)S(0.012)T(0.056)S(0.93)EEDEPGVVK 135.86 0.00040804 36398000.0 2671.4 3088.2 3156.1 3046.3 2928.1 2894.1 2626.9 2803.0 1394.5 2158.6 True False 2733.638422360462 2726.6321083347693 2727.518955216353 2514.3208911331903 2663.2538719980416 2864.9879816325542 2428.7508180706777 2728.6553345728253 2366.364649749741 2435.6773365445565 1.1223319203021433 1.1194553841039487 1.119819490986366 1.0322881661740153 1.0934345990903471 1.176259243639 0.9971562249358918 1.1202860467733013 0.9715427467526763 1.0 11.250107311256377 -8.107109022833958 1.218683779111067 0.9881052342409519 1.1026868926946705 0.39393194206458637 0.051098062601935744 0.4760719101663561 1.3122537490118564 0.04583259795163269 0.015337168797830534 7.81431613785036e-09 8.107109022833958 0.1145816584537186 VLSTS(ph)PTISK ddPTM_A459_Selumetinib_30min_R2 1 VLSTSPTISK 10 0 A0A087WX19;A0A087WX45;Q6IPM2-2;Q6IPM2-3;Q6IPM2-4;Q6IPM2;H7C427 A0A087WX19 IQCE IQ domain-containing protein E 1 VLS(0.001)T(0.047)S(0.906)PT(0.047)ISK 92.112 0.027084 6360900.0 44275.0 36032.0 38754.0 48929.0 48757.0 33559.0 31576.0 34346.0 37977.0 35538.0 True False 41814.37274686788 38795.53853885919 36260.60983216483 42264.785792767085 42631.70976688962 38181.44763172923 33044.34656665701 34445.941173713596 45573.461166038454 34511.92560118706 1.2115919937376558 1.1241197894076589 1.0506689847209691 1.22464293303047 1.2352747354503821 1.1063262036707668 0.9574761764530586 0.9980880687958137 1.3205134275228887 1.0 15.074807351085287 -6.994731443292696 24.682959913896095 1.0635802458872012 1.163996412076034 0.16769139507202813 0.10538576583710499 230.2704120981044 1078796.5329538612 0.03781768859002692 0.03323868710359156 1.0122051828193845e-07 6.994731443292696 0.10041616618883276 VLSTS(ph)TDLEAAVADALK ddPTM_A459_Selumetinib_30min_R1 1 VLSTSTDLEAAVADALK 17 0 Q7Z460 Q7Z460 CLASP1 CLIP-associating protein 1 1 VLS(0.002)T(0.023)S(0.937)T(0.038)DLEAAVADALK 227.63 3.0895e-16 129850000.0 2456.8 3307.8 2816.5 2553.8 3192.7 2613.1 2872.3 3239.7 1447.0 3316.4 True False 2514.038659899374 2920.5212382455006 2434.0347699270787 2107.8267707632035 2903.9208487169653 2586.8145865049655 2655.6400984980028 3153.7726319713083 2455.453315301453 3742.092244471585 0.6718270143162591 0.780451428625299 0.6504475600576182 0.5632749363346724 0.7760153034728365 0.6912749385926069 0.7096671928441468 0.8427832415490462 0.6561712418845473 1.0 11.86962940684352 -14.522878745280295 0.22730195652403884 2.566021940056603 0.6731181311140674 0.5927365337312244 0.07414361463822695 111.08898925577506 1.10919553967811 79.7800080137872 0.13129002801870757 3.0000000000002957e-15 14.522878745280295 -1.8929038089425356 VLSTS(ph)TDLEAAVADALK ddPTM_A459_Selumetinib_30min_R2 1 VLSTSTDLEAAVADALK 17 0 Q7Z460 Q7Z460 CLASP1 CLIP-associating protein 1 1 VLST(0.048)S(0.903)T(0.048)DLEAAVADALK 142.74 0.00049809 32507000.0 3595.4 3773.7 4470.1 3812.1 5114.0 2883.0 2362.9 4417.4 3072.0 3455.2 True False 3395.5820615265648 4063.1306556420104 4182.498632676885 3292.885403760702 4471.5336002599315 3280.107080731707 2472.7795319975253 4430.253902660064 3686.4858388516777 3355.439398312274 1.0119634594606244 1.2109086689766153 1.2464831386257809 0.9813574357554973 1.3326223690730439 0.977549194415951 0.7369465630168404 1.3203200465752423 1.0986596392430494 1.0 11.712285985888792 VLSTS(ph)TDLEAAVADALKKPVR ddPTM_A459_Selumetinib_30min_R1 1 VLSTSTDLEAAVADALKKPVR 21 2 Q7Z460 Q7Z460 CLASP1 CLIP-associating protein 1 1 VLS(0.048)T(0.174)S(0.643)T(0.135)DLEAAVADALKKPVR 87.323 0.0010901 13527000.0 1736.5 1670.9 3106.2 3471.7 2850.6 1797.3 1520.9 2069.5 1426.0 1489.0 True False 1776.9570713591922 1475.2702512196647 2684.3951011352715 2865.4327668801834 2592.763733314305 1779.2207938178317 1406.1772885163846 2014.6101373166111 2419.8178490807695 1680.1276540882257 1.0576321787427003 0.8780703344950695 1.5977328238145352 1.705485151623911 1.543194487041135 1.0589795302091984 0.8369466957434798 1.1990815890771722 1.4402583298909868 1.0 10.71435513607297 -6.781791398436784 24.980073627425718 1.102614099363221 1.3626463214531137 0.17342517474444097 0.2719506931849337 489.13064737440897 600354.9067021597 0.10784797336711538 0.09522227198429847 1.6527554638203613e-07 6.781791398436784 0.26003222208989274 VLT(ph)PEEQLADK ddPTM_A459_Selumetinib_30min_R1 1 VLTPEEQLADK 11 0 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 VLT(1)PEEQLADK 131.66 0.0050505 20456000.0 2920.0 4023.7 1718.4 1100.6 1767.7 2275.6 2912.9 3020.0 1350.5 3082.6 True False 2988.030318669069 3552.6033334326194 1485.050718495542 908.4008708207293 1607.8118471127832 2252.7095300794854 2693.177607810756 2939.899789657486 2291.6998633825924 3478.281737066732 0.8590535628056695 1.0213673307638855 0.42694952012366294 0.2611636835338107 0.46224313286038354 0.647650104381486 0.7742839170014842 0.8452161187312939 0.6588597579548586 1.0 11.764159078780747 -7.249017294242205 3.38462316296572 0.8118198788244259 0.5971643394356079 0.18066286782014507 0.2166917994587597 0.5203701380730741 12.62224187011423 0.10579863313993126 0.07404219911387146 5.6361521139605504e-08 7.249017294242205 -0.21465553938881798 VLT(ph)PEEQLADK ddPTM_A459_Selumetinib_30min_R2 4 VLTPEEQLADK 11 0 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 VLT(1)PEEQLADK;VLT(1)PEEQLADK;VLT(1)PEEQLADK;VLT(1)PEEQLADK 135.81 0.0034302 52327400.0 264698.0 176581.0 235176.0 248268.0 231932.0 196157.0 311034.0 296252.0 226707.0 203510.0 True False 249987.1448300494 190124.19490259467 220045.0322002685 214453.47011381193 202794.6286616126 223175.8462140444 325497.6973021789 297114.0442728411 272054.7347228345 197634.13751751842 1.264898604917839 0.962000782307874 1.1133958685693335 1.0851033774203236 1.0261113348580113 1.129237332261295 1.6469710212555084 1.5033538638865198 1.3765574011661794 1.0 17.592472640860855 -7.11574440292287 7.248886622077626 1.4226457595234938 1.0836320360117353 0.3948944661965411 0.17018138387747667 0.22247918241350478 12.591187064686402 0.06174995590484374 0.047811520676840545 7.660473191764652e-08 7.11574440292287 -0.3390137235117585 VLT(ph)PEEQLADKLR ddPTM_A459_Selumetinib_30min_R1 1 VLTPEEQLADKLR 13 1 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 VLT(1)PEEQLADKLR 91.592 0.027107 10161000.0 3670.3 3783.7 3819.6 3282.0 3478.6 3013.4 3982.4 3611.7 2418.4 3167.7 True False 3755.810848839412 3340.70264500559 3300.9192995609683 2708.8603107701592 3163.96124419671 2983.087931948285 3682.004361751366 3515.905983545011 4103.848167052548 3574.3051510109253 1.050780694473484 0.9346439388536076 0.9235135670012296 0.7578704660971682 0.8851961739477792 0.8345924049334664 1.0301315098152657 0.9836613929145369 1.148152716029814 1.0 11.803447092252805 -7.318886715872836 8.150518905811154 1.0397136807073872 0.8937546557714283 0.42573522537360775 0.08112711281051121 0.35839857280078635 47.11707352425716 0.035532776987514655 0.02393950632980132 4.798586016742784e-08 7.318886715872836 -0.14595902493595891 VLT(ph)PEEQLADKLR ddPTM_A459_Selumetinib_30min_R2 2 VLTPEEQLADKLR 13 1 O75822-2;O75822-3;O75822 O75822-2 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 VLT(1)PEEQLADKLR;VLT(1)PEEQLADKLR 119.0 0.004587399999999999 15873500.0 54554.0 55568.0 58198.0 57263.0 60463.0 41240.0 48624.0 45120.0 28350.0 53461.0 True False 51522.10707696507 59829.88692071848 54453.60404119132 49463.680615815225 52867.0973939218 46920.43566055348 50885.112346628164 45251.29172998188 34020.792165183935 51917.44202164056 0.9923853154300109 1.1524043672217095 1.048849903246266 0.9527372437801819 1.0182916441046035 0.9037509136331446 0.9801159372493333 0.8716009488895841 0.6552863708308889 1.0 15.663931682886401 -6.834395272081901 0.7638628596129815 0.8391532773837377 1.0675671670192666 0.4002231378048883 0.09647647340686931 0.6392333763644831 0.808030952347483 0.06858094279606435 0.06219291105226458 1.4642145829235446e-07 6.834395272081901 0.2284138896355289 VLT(ph)PPQAAGDGILATTANQR ddPTM_A459_Selumetinib_30min_R1 2 VLTPPQAAGDGILATTANQR 20 0 Q96QT6;Q96QT6-4;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7EPF7 Q96QT6 PHF12 PHD finger protein 12 1 VLT(1)PPQAAGDGILATTANQR;VLT(1)PPQAAGDGILATTANQR 201.48 1.9393e-15 23135000.0 4737.8 5245.4 5901.200000000001 5821.6 5088.4 4709.6 4501.1 4764.9 2629.3 4006.8 True False 4848.181521846001 4631.266129479698 5099.849452971304 4804.966844966349 4628.155118429983 4662.225699974662 4161.5784031436 4638.51937342349 4461.730063525989 4521.111809537071 1.0723427612692504 1.0243644317113019 1.1280078148506334 1.0627843431853419 1.023676324188026 1.031212209824123 0.9204767717456018 1.0259687370789532 0.9868656762954149 1.0 12.142461881387778 -6.61281256833616 1.8036272821497603 0.9868737356879781 1.0720272406950213 0.5250843579973397 0.03598054974164445 0.2815135056004439 1.8749410621620217 0.014082015905483867 0.014362173313822005 2.4388631493787915e-07 6.61281256833616 0.08515350500704322 VLT(ph)PPQAAGDGILATTANQR ddPTM_A459_Selumetinib_30min_R2 4 VLTPPQAAGDGILATTANQR 20 0 Q96QT6;Q96QT6-4;Q96QT6-5;Q96QT6-3;C9J9G2;Q96QT6-2;K7EPF7 Q96QT6 PHF12 PHD finger protein 12 1 VLT(1)PPQAAGDGILATTANQR;VLT(1)PPQAAGDGILATTANQR;VLT(1)PPQAAGDGILATTANQR;VLT(1)PPQAAGDGILATTANQR 166.34 8.013600000000001e-09 28307000.0 117740.0 105144.6 110671.0 124662.0 111020.0 80978.9 94474.9 94234.7 72335.1 106986.0 True False 111196.48215056391 113208.85272682435 103550.54834947415 107682.82054605518 97072.67506860736 92133.00842173613 98868.1700484629 94508.9073756056 86804.14121156272 103897.03619698928 1.0702565368634274 1.0896254298551868 0.9966650843931852 1.0364378473885245 0.9343161135468494 0.8867722487006414 0.9515975976543581 0.9096400709296101 0.8354823620471872 1.0 16.66479497444513 -6.039447475288957 1.1452291769198988 0.9093586258680241 1.0753193073741354 0.6577742839213894 0.04555954718117339 0.2908267470856659 0.7784919670917114 0.017500398922206353 0.0331752119314935 9.131718700103308e-07 6.039447475288957 0.16596068150611132 VLTANSNPS(ph)SPSAAK ddPTM_A459_Selumetinib_30min_R1 1 VLTANSNPSSPSAAK 15 0 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANS(0.062)NPS(0.73)S(0.208)PSAAK 257.48 3.1925999999999986e-36 23853000.0 2548.2 2930.2 2551.0 2701.7 2253.4 2357.1 2631.5 2311.0 1294.7 2265.0 True False 2607.5681020659335 2587.1308217869764 2204.588211639972 2229.8988121900484 2049.580367870083 2333.3897140755635 2433.0038363671956 2249.704772814056 2197.011338853346 2555.7348129683223 1.0202811687795614 1.01228453306632 0.8626044456777908 0.8725078990492615 0.801953456778885 0.9130014985261639 0.9519782036937617 0.8802575139637309 0.8596397903668487 1.0 11.319522432424467 -5.25325571562425 24.055681451365444 0.8873402493591023 1.016282890369063 0.4771627632014106 0.05147912404126667 290.60244083810494 854209.5809249483 0.013159148168599328 0.033489276897890316 5.581414603756077e-06 5.25325571562425 0.12894264100996078 VLTANSNPS(ph)SPSAAK ddPTM_A459_Selumetinib_30min_R2 2 VLTANSNPSSPSAAK 15 0 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.983)S(0.017)PSAAK;VLTANSNPS(0.951)S(0.049)PSAAK 358.02 4.683199999999996e-189 120075000.0 310380.0 266380.0 304680.0 339560.0 330140.0 225792.0 283130.0 260990.0 238514.0 275930.0 True False 293130.3221495845 286810.4894533 285077.2205105013 293311.3422263283 288664.861710953 256892.7984642988 296296.1060114518 261749.4376907796 286223.4646379778 267963.1839477617 1.0939201342178744 1.0703354290237592 1.063867119022126 1.0945956750667216 1.0772556791504126 0.9586869161637479 1.1057343835308864 0.9768111941146607 1.068144736979151 1.0 18.031675273684897 -6.576553752274772 24.999518763862028 1.0248121065867108 1.0796385110463687 0.33777699355626833 0.04059724926098188 110.55941591825419 51492.9835089344 0.01234272264000613 0.01234272446806072 2.6512229329956563e-07 6.576553752274772 0.05482640445965781 VLTANSNPS(ph)SPSAAKR ddPTM_A459_Selumetinib_30min_R1 1 VLTANSNPSSPSAAKR 16 1 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANS(0.045)NPS(0.483)S(0.472)PSAAKR 257.48 1.1379999999999999e-38 18726000.0 2684.0 3171.6 4356.5 4575.1 4025.5 3256.1 2890.1 3229.9 1914.6 2528.1 True False 2746.53197784513 2800.2675975631605 3764.9112285415667 3776.14467026342 3661.3942357597484 3223.3465903022543 2672.0974301671417 3144.2325598061966 3248.9363631486954 2852.6062607793424 0.9628149582391954 0.981652335292189 1.3198145430393116 1.3237525003649693 1.2835259762626483 1.1299654756494941 0.9367214350280206 1.1022315287729827 1.1389361398446465 1.0 11.478064913172217 -7.007292640325314 24.68558761603611 1.0501846886669282 1.1826695926115327 0.18502467307675663 0.12790904540552445 555.5751427569448 1880625.1860839098 0.05176852569101454 0.04381344427790513 9.833482736379967e-08 7.007292640325314 0.13248490394460455 VLTANSNPS(ph)SPSAAKR ddPTM_A459_Selumetinib_30min_R2 1 VLTANSNPSSPSAAKR 16 1 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.49)S(0.49)PS(0.021)AAKR 92.133 0.005663800000000001 31429000.0 49743.0 58009.0 67279.0 72293.0 60041.0 45191.0 39231.0 42207.0 32541.0 54047.0 True False 46978.48319700617 62458.1037716664 62950.342387836645 62446.56868761899 52498.112806649675 51415.65004694649 41055.31923475173 42329.81538225499 39050.10927150797 52486.522679029746 0.8950580225002364 1.1899836488238276 1.1993620299976087 1.1897638765192695 1.0002208210227759 0.9795971884319342 0.7822068816754517 0.8064892323142465 0.7440025987301669 1.0 15.679659399275724 -6.855745541357606 1.7895472615420003 0.8181328371538812 1.1245953915140279 0.5666264299701005 0.10799976069072262 0.23559279524889135 1.5518118722364784 0.04645333184966507 0.0395570457222122 1.3939733103545267e-07 6.855745541357606 0.3064625543601467 VLTANSNPSS(ph)PSAAK ddPTM_A459_Selumetinib_30min_R1 2 VLTANSNPSSPSAAK 15 0 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.421)S(0.579)PSAAK;VLTANSNPS(0.062)S(0.929)PS(0.009)AAK 280.62 3.3627e-55 149121000.0 10536.9 13640.5 11688.8 11564.5 10606.7 10109.3 11789.599999999999 10663.400000000001 5856.6 9247.9 True False 10782.38926876168 12043.463918703597 10101.52516198248 9544.977167550733 9647.325857764981 10007.609620509991 10900.30098013858 10380.571992395244 9938.222450860045 10434.958047174276 1.0332949322859508 1.1541458877225572 0.9680465523977753 0.914711599644184 0.9245198508850181 0.9590464643238304 1.044594614646325 0.9947880907107471 0.9523969723626494 1.0 13.34913717983107 -5.280272460230625 24.10945612510129 0.9682847390578524 1.0937203993919338 0.5517690743792901 0.04467351819095198 334.53965517068394 428265.909837807 0.012298062674975341 0.025680364188079702 5.244783187940484e-06 5.280272460230625 0.12543566033408138 VLTANSNPSS(ph)PSAAK ddPTM_A459_Selumetinib_30min_R2 2 VLTANSNPSSPSAAK 15 0 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.034)S(0.941)PS(0.025)AAK;VLTANSNPS(0.068)S(0.931)PS(0.001)AAK 296.44 2.494799999999999e-68 121250000.0 133672.0 118669.0 131499.0 140281.0 126936.0 93001.0 104008.0 115698.0 89265.0 109832.0 True False 126243.04537141323 127770.53071902451 123038.49750528575 121174.48580177731 110989.16485776192 105811.04357097801 108844.57808794215 116034.66202516499 107120.49427249166 106660.86478219286 1.1835929291329883 1.19791388322173 1.1535486587000479 1.1360725984101294 1.0405800204639974 0.9920324927708938 1.0204734258456327 1.0878841294050439 1.0043092608637423 1.0 16.702671404663207 -6.1220244229666925 2.0416267699204447 1.0245369906852106 1.1824759022063522 0.8785901466111355 0.02657946338259416 0.11238759141686246 0.9241426973337573 0.009234060624344233 0.013288392120715014 7.550497655238138e-07 6.1220244229666925 0.1579389115211416 VLTANSNPSS(ph)PSAAKR ddPTM_A459_Selumetinib_30min_R1 1 VLTANSNPSSPSAAKR 16 1 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.098)S(0.902)PSAAKR 117.27 0.00095211 31185000.0 2583.0 2464.9 4434.7 4053.4 3420.7 3189.1 2783.3 2885.7 1619.0 2088.3 True False 2643.178874356919 2176.3083620990797 3832.4920980634156 3345.549781741547 3111.2982889736354 3157.020549471121 2573.3534401523134 2809.161861925365 2747.3247529184896 2356.3536467645686 1.1217241851562396 0.9235915691548664 1.6264503010087998 1.4197995221707111 1.3203868159797052 1.339790635334353 1.0920913521133384 1.192164794865377 1.1659220833387003 1.0 11.202340362941348 -7.262649503391114 24.645046183573818 1.1285582873607352 1.2975207870068317 0.1922556554268574 0.17874080005003604 181.97304684981233 3705954.0566669963 0.07757122269305196 0.05559988975141917 5.461984918083502e-08 7.262649503391114 0.16896249964609655 VLTANSNPSS(ph)PSAAKR ddPTM_A459_Selumetinib_30min_R2 1 VLTANSNPSSPSAAKR 16 1 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.466)S(0.534)PS(0.001)AAKR 82.859 0.009954799999999998 33200000.0 58637.0 67433.0 71814.0 77370.0 78852.0 54681.0 46198.0 42435.0 39784.0 69327.0 True False 55378.19028250912 72604.89426873029 67193.56542517117 66832.07252930549 68945.90681417602 62212.81140530366 48346.298539600335 42558.47882450758 47741.91165783699 67325.34937682204 0.822545902770674 1.0784183809037289 0.9980425805009452 0.9926732374643069 1.0240705388439009 0.9240622140272404 0.7180994823956223 0.6321315703288293 0.7091223751491292 1.0 16.038862190988624 -7.1524273154979 3.7688920701722917 0.7340376817818323 0.9886152046559282 0.46170670457945484 0.10938160244330529 0.18115624671643124 4.624430311554759 0.042103785235715 0.031794982865328565 7.04000041109046e-08 7.1524273154979 0.25457752287409596 VLTANSNPSSPS(ph)AAK ddPTM_A459_Selumetinib_30min_R1 1 VLTANSNPSSPSAAK 15 0 Q9NV56 Q9NV56 MRGBP MRG/MORF4L-binding protein 1 VLTANSNPS(0.408)S(0.134)PS(0.458)AAK 204.67 5.667e-06 20767000.0 4190.0 4801.4 4202.9 4922.2 4112.5 4248.8 4902.2 4141.2 2334.9 3970.2 True False 4287.618847679246 4239.249855889695 3632.1692648771577 4062.630171137378 3740.5251011208475 4206.0609296017365 4532.423107216136 4031.361923486615 3962.1547656512544 4479.81384302288 0.9570975486753831 0.9463004500716357 0.8107857585497904 0.906874775045564 0.8349733342037319 0.9388918997499188 1.011743627310584 0.8998949654493545 0.8844462972099035 1.0 12.12922306754145 -6.9654889973516845 24.86709968664466 0.9456275409166477 0.8902960506478418 0.20435766693139168 0.05515305134615458 303.24684198988587 218505.2719190986 0.02008832738616072 0.017716149245351854 1.0827071446608037e-07 6.9654889973516845 -0.055331490268805905 VLTLS(ph)DDLER ddPTM_A459_Selumetinib_30min_R1 2 VLTLSDDLER 10 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 1 VLT(0.147)LS(0.853)DDLER;VLT(0.017)LS(0.983)DDLER 118.9 0.005566300000000001 8869400.0 2831.3 2704.4 3526.4 3624.5 3456.9 2781.2 3334.1000000000004 2802.4 2055.0 2445.7 True False 2897.263781249225 2387.767590758548 3047.5342491286515 2991.54911529142 3144.224005365264 2753.2236531275566 3082.606152700692 2728.0712485218996 3487.1849087384135 2759.629418135373 1.0498742194185076 0.8652493610435258 1.104327352470322 1.0840401597518665 1.1393645772517362 0.9976787589791153 1.1170362703205086 0.9885643451232679 1.2636424607672996 1.0 11.430258829740147 -5.2843544360166606 24.901303515959682 1.0860945028276048 0.9575617742574505 0.25661988441616235 0.08799996799210612 818.1202999471375 889032.6813861678 0.02122407031012092 0.04422678014108459 5.195717909995244e-06 5.2843544360166606 -0.1285327285701543 VLTLS(ph)DDLER ddPTM_A459_Selumetinib_30min_R2 1 VLTLSDDLER 10 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 1 VLT(0.146)LS(0.854)DDLER 84.507 0.04633 0.0 7578.5 8123.2 9558.9 9693.8 10162.0 7987.6 7007.7 8997.5 8378.2 10298.0 True False 7157.317309139204 8746.22331979521 8943.890780943404 8373.487717262266 8885.35871056735 9087.819395786537 7333.571935494117 9023.681235383685 10054.074106467158 10000.66998258272 0.7156837813470965 0.8745637377323451 0.8943291595983255 0.837292674575366 0.8884763446891251 0.9087210568505896 0.7333080631864014 0.9023076704960198 1.0053400546140856 1.0 13.28780903436659 -14.522877517769812 0.03882192775809099 1.7473955279232778 0.4289141079651771 0.3980628964670312 0.0702223518914145 1052.7868540486863 3.0447171468904943 91.67903073344884 28.451642177404025 3.000008479354295e-15 14.522877517769812 -1.3184814199581008 VLTLSERPLDFLDLERPPT(ph)TPQNEEIR ddPTM_A459_Selumetinib_30min_R1 1 VLTLSERPLDFLDLERPPTTPQNEEIR 27 2 A0A0A0MS29;Q9GZY8-2;C9JHF5;Q9GZY8-4;Q9GZY8-3;Q9GZY8;Q9GZY8-5 A0A0A0MS29;Q9GZY8-5 MFF Mitochondrial fission factor 1 VLTLSERPLDFLDLERPPT(0.5)T(0.5)PQNEEIR 78.352 0.00015408 75045000.0 1375.4 1319.1 1365.0 1417.4 1141.5 1378.5 1264.0 1822.8 723.18 969.41 True False 1407.4441439374784 1164.6591587670473 1179.6404974082946 1169.8776978932422 1038.2515265481936 1364.6335415778572 1168.6554623477612 1774.4534227111458 1227.183641022601 1093.8432163530326 1.2866964139797092 1.0647404868954813 1.0784365435307242 1.0695113160675027 0.949177643583889 1.2475586273942099 1.0683939387987968 1.6222191591838235 1.1219008562434907 1.0 10.095190252043475 VLVQNAAGS(ph)QEK ddPTM_A459_Selumetinib_30min_R2 1 VLVQNAAGSQEK 12 0 Q9Y490 Q9Y490 TLN1 Talin-1 1 VLVQNAAGS(1)QEK 91.62 0.022789 2292900.0 15145.0 17199.0 17012.0 17697.0 17700.0 17012.0 13712.0 15425.0 12305.0 17219.0 True False 14303.30153023859 18518.10799649864 15917.466441265124 15286.638070972202 15476.367759992327 19355.24858043977 14349.635169812544 15469.884196253786 14766.343830426398 16721.84272966516 0.8553663469674913 1.1074202942745561 0.9518966718319242 0.9141718600099704 0.9255180789696511 1.1574829935520712 0.8581371922817912 0.9251303487509571 0.8830572126019559 1.0 14.029446219220784 VMATTSAS(ph)LKR ddPTM_A459_Selumetinib_30min_R2 1 VMATTSASLKR 11 1 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0;F5H0N7 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 VMATTS(0.001)AS(0.999)LKR 106.54 0.0056779 8192500.0 39196.0 30756.0 38709.0 52704.0 52071.0 50615.0 58131.0 63687.0 54166.0 33670.0 True False 37017.643234019924 33114.88630387304 36218.50508317254 45525.62428052887 45529.375459353694 57586.756812776766 60834.206684391225 63872.31862604961 65000.71352449216 32697.859614833967 1.1321121220187211 1.0127539445685882 1.1076720467275285 1.3923120600797785 1.3924267825377317 1.7611781777499438 1.8604950721848688 1.953409776004812 1.987919524096416 1.0 14.996908580284142 -6.317578480606739 1.2657348771475971 1.7877135084348876 1.0710157311121946 0.47687463775228034 0.27309501918804757 0.33471827327205683 1.09700839581525 0.10657013227869325 0.145094535133076 4.813062701151278e-07 6.317578480606739 -0.716697777322693 VMDS(ph)DEDDDY ddPTM_A459_Selumetinib_30min_R2 2 VMDSDEDDDY 10 0 O14737;K7EQA1 O14737 PDCD5 Programmed cell death protein 5 1 VMDS(1)DEDDDY;VMDS(1)DEDDDY 172.88 0.0004963999999999999 5735500.0 35581.0 31752.0 39308.0 41794.0 43618.0 31256.0 29428.0 27729.0 28824.0 35418.0 True False 33603.550462028375 34187.27630122828 36778.966075314434 36101.58510132861 38138.31689013249 35561.230286281745 30796.46031047576 27809.68679921692 34589.60540985053 34395.390312984535 0.9769783147174453 0.9939493632762268 1.069299279369715 1.0496053329477693 1.108820587383623 1.0338952389459322 0.8953659205562162 0.8085294728787695 1.005646544350819 1.0 15.069927606737856 -7.248188091046766 12.244281135395504 0.9114256647757891 1.0418001131829775 0.42120140418345553 0.06279442055739244 0.8544195533643149 787.6556429255949 0.024533034216956826 0.018538443582134755 5.64692356046889e-08 7.248188091046766 0.13037444840718837 VMEQRLAQLFMMS(ph)QQQGRRFK ddPTM_A459_Selumetinib_30min_R1 1 VMEQRLAQLFMMSQQQGRRFK 21 3 H0YDE5;A0A5F9UK30;A0A590UJI0;Q6ZVL6-2;Q6ZVL6 H0YDE5 KIAA1549L UPF0606 protein KIAA1549L 1 VMEQRLAQLFMMS(1)QQQGRRFK 46.621 0.041886 0.0 1015.5 1140.9 998.63 1079.2 974.14 907.62 848.17 1051.3 578.11 984.66 True False 1039.1591741809723 1007.3228976099792 863.0215310819384 890.737979092978 886.0292089983856 898.4901668530243 784.1918540344151 1023.4161088963282 981.0104465161875 1111.0507024006124 0.9352941066827046 0.9066398999014971 0.7767616088241831 0.8017077683029121 0.7974696448001608 0.8086851166303075 0.7058110420523891 0.9211245775598406 0.8829574063510773 1.0 10.1177089397625 -8.458552028144942 1.5590978058845677 0.9934758314744427 0.8216068675415861 0.38147169795967995 0.06670972754359221 0.41162379003884947 2.181349313920897 0.06651250421036405 0.019593117631859985 3.4789482761972308e-09 8.458552028144942 -0.17186896393285667 VMGSLMHPS(ph)DLRAK ddPTM_A459_Selumetinib_30min_R2 1 VMGSLMHPSDLRAK 14 1 Q9Y2G1-2;Q9Y2G1 Q9Y2G1-2 MYRF Myelin regulatory factor;Myelin regulatory factor, N-terminal;Myelin regulatory factor, C-terminal 1 VMGSLMHPS(1)DLRAK 73.84100000000002 0.043794 10859000.0 66479.0 63408.0 60103.0 65526.0 65141.0 43770.0 54700.0 54180.0 37596.0 51526.0 True False 62784.36331652243 68271.18971114514 56236.03841519851 56601.24576134511 56957.405212071215 49798.92019550012 57243.65838599371 54337.654830018175 45116.250520009 50038.31049937438 1.254725882827467 1.3643783938708067 1.1238596558111535 1.131158210508582 1.1382759458432024 0.9952158595786872 1.1439966260793202 1.0859210530438983 0.9016341692946065 1.0 15.61074545851516 -4.401311688924288 0.31966034865443854 0.9858394745798692 1.6747404700481003 0.6578088842057624 0.0733823087644942 5.6891874334577945 0.39076817689910603 0.07601079768678462 1.5955827805714535 3.969065912268856e-05 4.401311688924288 0.6889009954682311 VMIYQDEVKLPAKLS(ph)ISK ddPTM_A459_Selumetinib_30min_R1 1 VMIYQDEVKLPAKLSISK 18 2 Q6NZI2 Q6NZI2 PTRF Polymerase I and transcript release factor 1 VMIY(0.001)QDEVKLPAKLS(0.935)IS(0.064)K 52.172 0.032636 44639000.0 5252.1 3270.0 10201.0 9649.3 6741.1 5409.6 4905.1 4749.6 3960.7 3050.0 True False 5374.463711192406 2887.1468798182427 8815.760230082062 7964.230894794173 6131.368695237871 5355.184335523813 4535.104357881334 4623.625179124896 6721.018621917392 3441.4972095158387 1.5616644105745194 0.8389217552858095 2.5616060956569227 2.314176188425446 1.7815992058004466 1.5560623791054007 1.317770749702089 1.343492351625461 1.9529344970362266 1.0 11.748820624828479 -6.8453800166726335 3.604273551281618 1.4338305643843885 1.8289320212559337 0.138130189819602 0.4801703982465462 0.5555579900466625 14.14064863263848 0.18908665174798187 0.16816269967983083 1.4276441935477348e-07 6.8453800166726335 0.3951014568715452 VMLADS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VMLADSPR 8 0 H7BZE0;H7C476;Q8IUH3-3;Q8IUH3 H7BZE0 RBM45 RNA-binding protein 45 1 VMLADS(1)PR 90.149 0.028672000000000007 6430800.0 34801.0 24954.0 30490.0 33931.0 34590.0 25249.0 33703.0 32471.0 31413.0 26046.0 True False 32866.89973944095 26867.89156024344 28528.306595001977 29309.53926576018 30244.494961476543 28726.820562398505 35270.256281227565 32565.485234136584 37696.477752554594 25293.98430436487 1.2993959094759642 1.0622245683771918 1.1278692297630222 1.1587553353823488 1.1957188949570663 1.1357174977546438 1.3944128317949946 1.2874794592371477 1.490333721210125 1.0 14.62650668754317 -7.24888112514017 24.89787541460419 1.31701312572075 1.1583460088656907 0.18316138941717985 0.13014319054402915 960.6961479381807 1904670.3504522913 0.046545746654688254 0.03580493134724961 5.637919555485713e-08 7.24888112514017 -0.1586671168550593 VMLGET(ph)NPADSKPGTIR ddPTM_A459_Selumetinib_30min_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 VMLGET(1)NPADSKPGTIR;VMLGET(0.958)NPADS(0.025)KPGT(0.017)IR 192.4 1.0788e-19 10518000.0 2807.9 4395.1 3015.1 3994.4 2545.0 2835.2 2848.2 2118.32 1713.85 1906.8899999999999 True False 2873.318606777698 3880.5196487734443 2605.66598075879 3296.8530241743792 2314.8051993562435 2806.6804621556325 2633.357980901024 2062.135272326902 2908.2782753485785 2151.6579061815282 1.3353975083691978 1.803502144846095 1.2110038372145198 1.5322384728087137 1.0758239926086797 1.3044269045243115 1.2238739129187837 0.958393649103124 1.3516452903564944 1.0 11.071233005545809 -6.034122365160728 0.856953019502418 1.1354574818231935 1.5578267815389522 0.37560110593621154 0.18995875651052782 0.687242743924582 1.0258114490163408 0.0853695238730224 0.19046401461771403 9.244376712000686e-07 6.034122365160728 0.42236929971575865 VMLGET(ph)NPADSKPGTIR ddPTM_A459_Selumetinib_30min_R2 1 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 VMLGET(1)NPADSKPGTIR 94.313 0.0094904 7784500.0 38063.0 39785.0 45659.0 32387.0 43542.0 28236.0 15780.0 28933.0 19555.0 31418.0 True False 35947.61083826159 42836.38157106219 42721.34964976042 27975.834729308765 38071.86468958111 32125.252699112232 16513.80126747681 29017.190239884003 23466.546412351745 30510.880706232656 1.1781898786985308 1.4039706681528772 1.4002004747451768 0.9169133791537508 1.2478127083956618 1.052911353442177 0.5412430216772939 0.9510440068665889 0.7691205848265822 1.0 14.897036203916237 -7.01646279685282 5.602298569752487 0.8075437281422998 1.2255790111648068 0.566505949502778 0.17056173134028366 0.12973473474900113 13.599002193514131 0.06479894955597676 0.0527596805696019 9.628024863869637e-08 7.01646279685282 0.41803528302250703 VMLGETNPADS(ph)KPGTIR ddPTM_A459_Selumetinib_30min_R2 1 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 VMLGETNPADS(0.867)KPGT(0.133)IR 73.296 0.013992 9905300.0 18902.0 19735.0 17339.0 16423.0 15495.0 13227.0 14135.0 15853.0 11982.0 17900.0 True False 17851.502510701222 21248.61104197341 16223.427617275798 14186.159068744786 13548.379572942433 15048.89918724881 14792.305507971134 15899.129605394566 14378.734805052336 17383.18049021467 1.0269411009538894 1.2223661287952838 0.9332830448609954 0.8160853577244079 0.7793958982689664 0.8657160981398155 0.8509550663814376 0.9146271946232449 0.8271636374682071 1.0 14.085404446608115 -5.4383175692762356 4.929638090278214 0.8580442360510914 1.1216288323555967 0.6679034599311315 0.07203104093873068 0.11192323999241176 4.632846717709859 0.018129501678593743 0.03857832096761081 3.6448732528712437e-06 5.4383175692762356 0.26358459630450537 VMLGETNPADSKPGTIR ddPTM_A459_Selumetinib_30min_R1 1 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 188.9 1.9596e-07 34260000.0 1894.7 1823.9 2419.0 2245.1 2181.2 1698.7 2033.6 1864.6 1375.9 1614.0 False True 1938.8428235555773 1610.3569400918948 2090.5130866158715 1853.0354307465202 1983.9108451221375 1681.6126202961962 1880.2039147392477 1815.1447509256104 2334.8018082399935 1821.1726216913344 1.0646123274986212 0.8842417906526325 1.1478939787017 1.017495765462142 1.0893590324675906 0.9233680543332965 1.0324138922059407 0.9966901156464093 1.2820321261318153 1.0 10.83065196076865 -8.187450133518452 24.999984155708553 1.1410321230739593 1.0187664726589827 0.2053337867703272 0.09560502979978405 171.267958028229 57868.70575763281 0.05991279090947489 0.02264489680140278 6.494561990360138e-09 8.187450133518452 -0.12226565041497661 VMLGETNPADSKPGTIR ddPTM_A459_Selumetinib_30min_R2 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 ; 178.85 2.365e-07 48979000.0 195031.0 158286.0 190754.0 213350.0 203050.0 154340.0 173973.0 170361.0 136866.0 178320.0 False True 184191.95779095186 170426.02723029157 178481.0953172517 184291.3619507219 177541.0437099685 175598.93404097532 182063.08922095934 170856.72230521814 164243.02435555772 173171.43826899864 1.0636393601168475 0.9841462826309588 1.0306612747536648 1.0642133817959631 1.0252328298745332 1.014017876136167 1.0513459438856696 0.9866333848877267 0.9484417638226702 1.0 17.401841475716246 -7.896930771008121 5.502967187868017 0.9721887181989184 1.031300240606466 0.49734936092477033 0.025402547191578327 0.16435149801055848 7.346934077866051 0.014022040167682888 0.006563036077234542 1.2678539528272571e-08 7.896930771008121 0.05911152240754758 VMPT(ph)KSPPPPGGGNLGMNSR ddPTM_A459_Selumetinib_30min_R1 1 VMPTKSPPPPGGGNLGMNSR 20 1 Q02078-3;Q02078-5;Q02078;Q02078-8;Q02078-7;Q02078-4;Q02078-6;Q02078-2 Q02078-3 MEF2A Myocyte-specific enhancer factor 2A 1 VMPT(0.5)KS(0.5)PPPPGGGNLGMNSR 81.60600000000002 0.0050331 28425000.0 1948.4 2293.9 2736.0 3041.3 2701.1 2292.7 2377.1 2114.1 1259.3 1854.7 True False 1993.7939290735658 2025.329121594821 2364.46622777223 2510.194047271567 2456.7859819179366 2269.637519605044 2197.7934331858114 2058.027200435394 2136.9401243670495 2092.768811307878 0.9527062513071104 0.9677748973758308 1.1298267706381548 1.1994607496576837 1.173940460428864 1.084514212626588 1.0501845312824105 0.9833992122375085 1.0211066376852045 1.0 11.031197230177453 -7.513162477236035 3.1847987266788365 1.0020387610212855 1.090288751186428 0.19722434532081412 0.07435266361067058 0.4654667514009586 9.737645352719365 0.043207827006100645 0.024838330824782876 3.0678740278108766e-08 7.513162477236035 0.08824999016514257 VMPT(ph)KSPPPPGGGNLGMNSR ddPTM_A459_Selumetinib_30min_R2 1 VMPTKSPPPPGGGNLGMNSR 20 1 Q02078-3;Q02078-5;Q02078;Q02078-8;Q02078-7;Q02078-4;Q02078-6;Q02078-2 Q02078-3 MEF2A Myocyte-specific enhancer factor 2A 1 VMPT(0.943)KS(0.057)PPPPGGGNLGMNSR 74.744 0.0087947 13106000.0 16493.0 21835.0 23612.0 20476.0 24480.0 14758.0 14826.0 10382.0 9725.2 20663.0 True False 15576.385086710145 23509.674289409144 22092.829626801795 17687.133476929823 21404.603546023296 16790.780540214546 15515.438377161663 10412.209901167382 11670.511744791782 20066.405501078516 0.7762419176604876 1.1715937011312545 1.100985905303985 0.8814300835283722 1.0666884781568307 0.8367607511625381 0.7732046666916877 0.5188876453537109 0.5815945334187791 1.0 14.29249458916456 -7.113417170834052 2.0757957554030195 0.6675469645453538 1.008450281289632 0.3926918913886177 0.1607979167402467 0.28748148202207413 2.4397671325781825 0.07231650474137931 0.051947401735773564 7.701633168246997e-08 7.113417170834052 0.3409033167442783 VMS(ph)GYSGTSPHEKTS(ph)ARNHRHY(ph)QDT(ph)ASR ddPTM_A459_Selumetinib_30min_R2 1 VMSGYSGTSPHEKTSARNHRHYQDTASR 28 3 Q05469 Q05469 LIPE Hormone-sensitive lipase 4 VMS(0.312)GY(0.296)S(0.309)GT(0.143)S(0.143)PHEKT(0.142)S(0.673)ARNHRHY(0.881)QDT(0.876)AS(0.226)R 40.142 0.028789 17309000.0 23103.0 25571.0 30024.0 22741.0 27629.0 22359.0 23406.0 19707.0 17871.0 20133.0 True False 21819.027748636676 27532.213476275774 28092.28852765954 19643.636569586877 24157.998013606106 25438.749295206468 24494.42537810914 19764.344107330522 21445.699357460395 19551.707978183913 1.1159653045648326 1.4081743399091593 1.436820177500878 1.0047018189666876 1.2355952758992699 1.3011011275123074 1.2528023334554907 1.0108755782044143 1.096870891350762 1.0 14.255007022070565 -7.756106757995778 24.813899182306134 1.0404049025062463 1.2558413324350801 0.3971202648585148 0.12114272057563515 122.83382876682165 571582.6246035546 0.060891774373052904 0.033813029123523373 1.75344941702905e-08 7.756106757995778 0.21543642992883383 VMS(ph)PENFPTASVEGK ddPTM_A459_Selumetinib_30min_R1 4 VMSPENFPTASVEGK 15 0 H3BRU9;H3BSP3;H3BTW3;Q3L8U1-2;Q3L8U1-3;Q3L8U1 H3BRU9 CHD9 Chromodomain-helicase-DNA-binding protein 9 1 VMS(1)PENFPTASVEGK;VMS(1)PENFPTASVEGK;VMS(0.995)PENFPT(0.005)ASVEGK;VMS(1)PENFPTASVEGK 261.64 1.7287e-36 47485200.0 7231.1 7583.9 7820.799999999999 8360.1 7550.1 6656.099999999999 7630.799999999999 7208.700000000001 3819.85 6184.0 True False 7399.570560728735 6695.973462340539 6758.7783165793335 6900.165473512977 6867.194788078421 6589.145677255259 7055.202612407672 7017.5018588423545 6482.006459194372 6977.776637260974 1.060448183625627 0.9596141880759524 0.9686148852182799 0.9888773791735382 0.9841522801701545 0.9443044711505316 1.0110960810544216 1.0056931059342384 0.9289501221034772 1.0 12.768551701415717 -4.753881103780423 24.99002609380655 0.9773951786276498 1.0604483321201739 0.49342704096360457 0.02541688120700444 230.08463572228146 760669.0698294671 0.006155696257832651 0.06322031068152623 1.762458486273205e-05 4.753881103780423 0.08305315349252407 VMS(ph)PENFPTASVEGK ddPTM_A459_Selumetinib_30min_R2 6 VMSPENFPTASVEGK 15 0 H3BRU9;H3BSP3;H3BTW3;Q3L8U1-2;Q3L8U1-3;Q3L8U1 H3BRU9 CHD9 Chromodomain-helicase-DNA-binding protein 9 1 VMS(1)PENFPTASVEGK;VMS(0.97)PENFPT(0.009)AS(0.021)VEGK;VMS(0.963)PENFPT(0.034)AS(0.003)VEGK;VMS(1)PENFPTASVEGK;VMS(1)PENFPTASVEGK;VMS(1)PENFPTASVEGK 259.29 2.5545e-36 37662600.0 170670.0 151452.0 193635.0 185881.0 195015.0 137725.0 151025.0 158522.0 138517.0 163263.0 True False 161184.8446461421 163067.88140506519 181176.73491384726 160563.68713738988 170515.47224378 156695.36860692847 158047.96175036006 158983.2727752702 166224.27048835196 158549.1729817829 1.0166236859820268 1.028500359467668 1.142716366831281 1.01270592660763 1.0754737412813375 0.9883077007593888 0.9968387647693348 1.002737950538141 1.0484083099408592 1.0 17.274570826566723 -6.761988745588622 24.999999305555853 1.0067784291057804 1.0562212731606675 0.28620036138200844 0.03783827485630464 19.83633721822473 902639.9026919749 0.012973332557632219 0.012136603766060941 1.729861186671998e-07 6.761988745588622 0.04944284405488708 VMTIPYQPMPAS(ph)SPVICAGGQDR ddPTM_A459_Selumetinib_30min_R2 3 VMTIPYQPMPASSPVICAGGQDR 23 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 VMTIPYQPMPAS(0.833)S(0.167)PVICAGGQDR;VMTIPYQPMPAS(0.599)S(0.401)PVICAGGQDR;VMTIPYQPMPAS(0.962)S(0.038)PVICAGGQDR 122.22 1.9664e-05 12343500.0 83440.0 73573.0 82809.0 89064.0 87890.0 70955.0 73710.0 70772.0 66435.0 78008.0 True False 78802.73883678504 79215.81252551872 77481.15909562216 76933.32955603026 76848.47245343085 80728.40718464044 77137.66105359406 70977.93480306477 79723.85634899451 75755.70635087526 1.0402218213344474 1.0456745285776545 1.022776538268354 1.0155450098993288 1.0144248685042188 1.0656412707807552 1.018242252224777 0.9369318592888377 1.0523808725344082 1.0 16.20906694422799 -7.532521391977025 24.98688054772456 0.9923112298421722 1.0331315284640827 0.24095464962379443 0.02960622717773132 264.0303155508452 684168.4713498579 0.01317156897136942 0.007615663909444902 2.9341249746503177e-08 7.532521391977025 0.0408202986219105 VMTIPYQPMPASS(ph)PVICAGGQDR ddPTM_A459_Selumetinib_30min_R1 2 VMTIPYQPMPASSPVICAGGQDR 23 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 VMTIPYQPMPAS(0.034)S(0.966)PVICAGGQDR;VMTIPYQPMPAS(0.163)S(0.837)PVICAGGQDR 158.33 1.0397e-09 99141000.0 8654.2 10283.1 11517.4 12082.7 10282.0 8884.5 9985.3 7879.799999999999 4882.4 8493.6 True False 8855.826021858169 9079.149871516502 9953.400340549666 9972.683265369462 9351.994915434543 8795.129996480566 9232.100781788846 7670.802106802335 8285.076203612864 9583.836294670076 0.9240376973867155 0.9473398326477833 1.0385611809839779 1.0405732066725344 0.9758091256875424 0.9177045314694974 0.963299090044261 0.8003895174073821 0.8644843201485505 1.0 13.226387549749893 -7.126456637624442 1.6180150500799622 0.8831165664738201 0.9884296572070186 0.26306028460096753 0.061144811317682936 0.450369284791329 2.3353845821115233 0.032534159431768184 0.022045946827490493 7.473832533651528e-08 7.126456637624442 0.1053130907331985 VMTIPYQPMPASS(ph)PVICAGGQDR ddPTM_A459_Selumetinib_30min_R2 3 VMTIPYQPMPASSPVICAGGQDR 23 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 VMTIPYQPMPAS(0.415)S(0.585)PVICAGGQDR;VMTIPYQPMPAS(0.286)S(0.714)PVICAGGQDR;VMTIPYQPMPAS(0.335)S(0.665)PVICAGGQDR 137.11 3.0685000000000008e-06 54989100.0 304416.0 271428.0 356797.0 334605.0 386774.0 287980.0 256478.0 313490.0 262827.0 295716.0 True False 287497.77739380056 292245.65482142114 333841.0694712007 289031.2217741792 338183.99231656897 327646.6309778414 268404.73520151566 314402.203998937 315399.7439999576 287177.9107175604 1.001113827576226 1.0176467058040717 1.1624886769217202 1.0064535292842964 1.1776114377027176 1.1409186387600752 0.9346287621177516 1.09479939878855 1.0982729946460033 1.0 18.131585257985577 -5.028322163337006 24.601196189320493 1.0793355879771562 1.0052469787223561 0.12096192687775464 0.07316138611904953 993.7099605935841 863159.8047670884 0.018404252040900886 0.04895770333387165 9.368667733593618e-06 5.028322163337006 -0.0740886092548001 VNASASS(ph)LK ddPTM_A459_Selumetinib_30min_R2 4 VNASASSLK 9 0 Q16658 Q16658 FSCN1 Fascin 1 VNASAS(0.05)S(0.949)LK;VNAS(0.002)AS(0.226)S(0.772)LK;VNAS(0.005)AS(0.059)S(0.936)LK;VNAS(0.016)AS(0.081)S(0.902)LK 116.84 0.007722700000000002 38753700.0 328040.0 292015.0 303964.0 327498.0 291215.0 212739.0 251451.0 281480.0 197918.0 269626.0 True False 309808.850048166 314411.61152378394 284407.2871709792 282892.20743443887 254629.96820486835 242041.86619763565 263143.96974070405 282299.06019847747 237507.1302909653 261841.19680752108 1.1831936831388143 1.2007721296618854 1.0861823526572345 1.0803960984122463 0.972459533906142 0.9243842036650946 1.0049754314793353 1.0781308046265727 0.9070655541860981 1.0 17.998332576128313 -5.680316394201607 1.3750511010055915 0.9843109774332128 1.1984376046714011 0.741216007710692 0.048221847305098424 0.23764790867635605 0.880633320742734 0.016333510079756572 0.04423401666567002 2.087774581594565e-06 5.680316394201607 0.21412662723818832 VNASASS(ph)LKK ddPTM_A459_Selumetinib_30min_R1 2 VNASASSLKK 10 1 Q16658 Q16658 FSCN1 Fascin 1 VNASAS(0.035)S(0.965)LKK;VNASAS(0.006)S(0.994)LKK 151.13 0.0012279 44721000.0 5577.6 5483.1 6353.3 6335.0 5044.9 5640.9 5618.3 5390.0 3584.0 4749.5 True False 5707.547227879661 4841.136102975968 5490.556756178844 5228.711172677923 4588.589685749438 5584.157667527407 5194.507107680723 5247.0396908125285 6081.786234996824 5359.144589047701 1.065010867507471 0.9033411998007352 1.0245211087231543 0.9756615231773481 0.8562168102586709 1.0419867526880238 0.9692791491941751 0.9790815686398391 1.1348427223676631 1.0 12.387787024967327 -8.149022218919853 8.590109488546052 1.067027820370394 0.973556980875319 0.23087128697303771 0.06592846121581801 0.3936655667765434 26.85383248979139 0.042238384559366904 0.015884090242163185 7.095414662167243e-09 8.149022218919853 -0.09347083949507506 VNASASS(ph)LKK ddPTM_A459_Selumetinib_30min_R2 1 VNASASSLKK 10 1 Q16658 Q16658 FSCN1 Fascin 1 VNASAS(0.358)S(0.642)LKK 139.48 0.0027354 7924900.0 17948.0 18213.0 16001.0 17528.0 17839.0 15545.0 15646.0 15093.0 13358.0 16112.0 True False 16950.522011536636 19609.878535974753 14971.513080571536 15140.656162513465 15597.905337316555 17686.182646539863 16373.570001960847 15136.918131219343 16029.973253704664 15646.804695996567 1.0833216328106685 1.2532832688192361 0.9568415642333791 0.9676516360166107 0.9968748022596253 1.1303383016639235 1.0464481611475749 0.9674127353997277 1.0244886138194167 1.0 13.933580447575917 -5.267862840789685 24.997943096405347 1.013531894855459 1.1683024530364416 0.514505518059137 0.06098942369220618 375.07043527254103 1459652.385754537 0.016370911925516447 0.035427477510276494 5.396810380751712e-06 5.267862840789685 0.15477055818098262 VNDAEPGS(ph)PEAPQGK ddPTM_A459_Selumetinib_30min_R1 6 VNDAEPGSPEAPQGK 15 0 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 1 VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK 248.1 6.5607999999999986e-28 460489600.0 39515.509999999995 42801.2 41033.31 43467.6 39767.1 34549.39 39152.13 37833.59 20139.640000000003 33006.06 True False 40436.144499202324 37790.01560626196 35461.21188183794 35876.799647907654 36170.172826451744 34201.8545049362 36198.8533125393 36830.12029237999 34175.4981388927 37242.709307249956 1.085746586415256 1.0146956628342143 0.9521652033767259 0.9633241059861237 0.9712014377914922 0.9183503332900166 0.9719715344525848 0.9889216165379877 0.9176426413273813 1.0 15.184670408460024 -4.890151595820318 2.185324390745145 0.9592372269785581 1.1037405925680408 0.7037294400080529 0.02536965387672637 0.25864496478322063 1.734891798086608 0.0065064975658529105 0.0678271807578726 1.2877999508464454e-05 4.890151595820318 0.14450336558948274 VNDAEPGS(ph)PEAPQGK ddPTM_A459_Selumetinib_30min_R2 6 VNDAEPGSPEAPQGK 15 0 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 1 VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK;VNDAEPGS(1)PEAPQGK 241.51 3.3405000000000004e-20 554190700.0 824542.0 694118.0 822687.0 831830.0 838652.0 661140.0 731076.0 779188.0 644936.0 666765.0 True False 778717.2565431491 747354.6186588558 769756.2140938776 718533.3190132127 733293.0381159944 752206.033768631 765072.4825996115 781455.3080784818 773941.2210174614 647513.7619864807 1.2026265729922938 1.1541910960565185 1.1887874193320223 1.1096803824043122 1.1324748309076167 1.1616834698014282 1.181554010917818 1.206855134138134 1.1952506131192009 1.0 19.30455132999841 -2.663933479852504 1.3045536157278108 1.154120126664474 14.008273563383678 0.06624203043739763 0.05718987852224415 1291.7907752625697 10.951226180315496 0.015912742018417796 49119.052709878924 0.00216803615380139 2.663933479852504 12.854153436719205 VNFPENGFLS(ph)PDKLSLLEK ddPTM_A459_Selumetinib_30min_R1 2 VNFPENGFLSPDKLSLLEK 19 1 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 VNFPENGFLS(1)PDKLSLLEK;VNFPENGFLS(0.999)PDKLS(0.001)LLEK 105.32 0.00047765 549610000.0 14470.4 16671.6 20368.1 20448.6 15050.6 15896.0 14471.5 14159.0 10679.1 14535.5 True False 14807.532165503044 14719.681321583435 17602.223893964765 16877.635877761935 13689.275887399248 15736.100672413206 13379.903103928515 13783.457325086198 18121.652729395813 16401.27301275983 0.9028282227838723 0.8974718797822491 1.073223028497277 1.0290442616638054 0.8346471567633373 0.9594438590328241 0.8157844268258473 0.8403894816190774 1.1048930601482925 1.0 14.001520175973267 -3.6533683826035457 15.216379667292625 0.9395327840844999 0.2307679239556727 0.0 0.09825605921934408 0.0 0.0 0.022775946088095463 0.0 0.0002221424807015701 3.6533683826035457 -0.7087648601288272 VNFPENGFLS(ph)PDKLSLLEK ddPTM_A459_Selumetinib_30min_R2 1 VNFPENGFLSPDKLSLLEK 19 1 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 VNFPENGFLS(0.999)PDKLS(0.001)LLEK 52.227 0.040557 81685000.0 56840.0 57186.0 48977.0 47621.0 42200.0 42252.0 47245.0 37509.0 30471.0 42201.0 True False 53681.060348548126 61571.98231802846 45825.87314212563 41134.93764919297 36898.45872721333 48071.82947453216 49441.986114191466 37618.14498005076 36566.051430875465 40982.54747863404 1.3098517210657625 1.5023951927373127 1.1181802001453576 1.0037184162511708 0.9003456592455624 1.172982950842528 1.2064156368016823 0.9179064576125413 0.8922347116156923 1.0 15.322722044732267 -5.408248798389414 4.2670900928435636 1.0220687852585004 1.4030948392069835 0.6648615834097511 0.1095871307727665 0.13847822122167008 4.143092174027701 0.03123289218213716 0.06843556966582276 3.906170551930117e-06 5.408248798389414 0.3810260539484831 VNFS(ph)EEGETEEDDQDSSHSSVTTVK ddPTM_A459_Selumetinib_30min_R2 1 VNFSEEGETEEDDQDSSHSSVTTVK 25 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;H0YD16;Q5JTV8-2 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 VNFS(0.547)EEGET(0.453)EEDDQDSSHSSVTTVK 81.406 0.00011446 7279600.0 17789.0 9804.1 34248.0 45698.0 33920.0 23873.0 26517.0 24074.0 27921.0 32770.0 True False 16800.358595009213 10556.042944849836 32044.52096640298 39473.853566552985 29658.666351352545 27161.289052482854 27750.093042438686 24144.051354334766 33505.98017792241 31823.844953314783 0.5279173091640921 0.3317023119090553 1.0069342976441698 1.240386057198955 0.9319636390530895 0.8534886055512196 0.8719905807468505 0.7586780098304845 1.0528576992213008 1.0 14.957820531999255 -5.264654914632794 24.909631997470125 0.9573358531159577 0.429809785769428 0.7278001975133976 0.13074748139155148 131.81627610154405 1021143.8815533593 0.036808535978237876 0.08211040760220294 5.436821634578888e-06 5.264654914632794 -0.5275260673465296 VNFSEEGET(ph)EEDDQDSSHSSVTTVK ddPTM_A459_Selumetinib_30min_R2 1 VNFSEEGETEEDDQDSSHSSVTTVK 25 0 A0A0A0MSK5;J3KN66;Q5JTV8;Q5JTV8-3;H0YD16;Q5JTV8-2 A0A0A0MSK5 TOR1AIP1 Torsin-1A-interacting protein 1 1 VNFS(0.114)EEGET(0.877)EEDDQDS(0.008)S(0.001)HSSVTTVK 84.646 0.00014339 7348400.0 19480.0 7622.5 27239.0 40788.0 27313.0 17687.0 26210.0 27480.0 28858.0 32596.0 True False 18397.379584618553 8207.121239799464 25486.472395580786 35232.60403677543 23881.696758681956 20123.22370339983 27428.816934129733 27559.962250441116 34630.40635988987 31654.86878542106 0.5811864111435406 0.2592688440894542 0.8051359355916463 1.1130232216600477 0.7544399226725239 0.6357070642057998 0.866495992135097 0.8706389667024654 1.0939993652995088 1.0 14.95013979491763 -5.373629926545595 5.633631187020643 0.8853866886842393 0.42426451678570964 0.598559271947116 0.15560547754114037 0.14825277802349107 6.319771738186821 0.04192394716544547 0.08927915810078789 4.230289345176018e-06 5.373629926545595 -0.46112217189852966 VNGDAS(ph)PAAAESGAK ddPTM_A459_Selumetinib_30min_R1 3 VNGDASPAAAESGAK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 VNGDAS(0.997)PAAAES(0.003)GAK;VNGDAS(0.994)PAAAES(0.006)GAK;VNGDAS(1)PAAAESGAK 191.4 2.8635e-05 153561000.0 14824.499999999998 15063.3 12200.1 11448.2 12963.3 12208.1 16195.3 14680.900000000001 7693.3 13296.400000000001 True False 15169.88200654439 13299.681833261819 10543.393430352338 9448.986779329352 11790.771803856496 12085.297598067922 14973.67548208917 14291.514841716076 13054.968203599627 15003.122457903743 1.0111149895035882 0.8864609264223835 0.7027466089099346 0.6298013500750682 0.7858878601397432 0.8055188266294067 0.9980372768470566 0.9525693655981068 0.8701500797737063 1.0 13.872975165986247 -7.219111073633636 8.409107371756008 0.9511642906436911 0.7938276447102681 0.3476135530648463 0.10116134614907649 0.4340041997831422 81.34241684374364 0.04284572108104594 0.03298387354661334 6.037941853438313e-08 7.219111073633636 -0.157336645933423 VNGDAS(ph)PAAAESGAK ddPTM_A459_Selumetinib_30min_R2 4 VNGDASPAAAESGAK 15 0 P29966 P29966 MARCKS Myristoylated alanine-rich C-kinase substrate 1 VNGDAS(1)PAAAESGAK;VNGDAS(0.999)PAAAES(0.001)GAK;VNGDAS(1)PAAAESGAK;VNGDAS(1)PAAAESGAK 222.96 1.1474e-09 255928000.0 220424.0 163059.0 200545.0 223090.0 211270.0 163741.0 214998.0 210553.0 160066.0 185636.0 True False 208173.71650718478 175565.1009826774 187642.15303688688 192704.75714828406 184728.3738222363 186294.83645719427 224995.83301045484 211165.67437107422 192083.67261771858 180276.2063397479 1.154748708849915 0.9738672925688708 1.0408592284400369 1.0689417148323686 1.0246963677175336 1.0333856044546648 1.248061724720502 1.171345229958479 1.0654965317814507 1.0 17.45984947042578 VNGDDHHEEDMDMS(ph)D ddPTM_A459_Selumetinib_30min_R1 1 VNGDDHHEEDMDMSD 15 0 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 VNGDDHHEEDMDMS(1)D 136.83 0.00056719 0.0 2350.7 2838.9 2631.9 2633.0 2846.7 2166.3 2418.0 2585.7 1196.0 2113.6 True False 2405.4667363340345 2506.5202682311974 2274.502435991862 2173.1959775313294 2589.216487625704 2144.5089888430252 2235.6083132570316 2517.1188364626996 2029.5246476161278 2384.9011482074357 1.0086232455135746 1.0509954553525938 0.953709313151804 0.9112310500436338 1.0856703597848647 0.8992024639909724 0.9374008289347266 1.0554394836677583 0.850989001846714 1.0 11.219713753850334 -5.2677563092495445 24.37226118442262 0.9632097014454302 1.0298093511392068 0.1388773205172652 0.0677515480799814 627.5855987816353 2421391.6823453633 0.01683895695862153 0.03653554345509294 5.398134369579728e-06 5.2677563092495445 0.06659964969377663 VNGDDHHEEDMDMS(ph)D ddPTM_A459_Selumetinib_30min_R2 1 VNGDDHHEEDMDMSD 15 0 Q5T757;Q05519-2;Q05519 Q5T757 SRSF11 Serine/arginine-rich splicing factor 11 1 VNGDDHHEEDMDMS(1)D 148.57 0.00030202 44042000.0 220680.0 176210.0 207850.0 228990.0 275650.0 179710.0 153980.0 199420.0 154610.0 185600.0 True False 208415.489052034 189724.74039554762 194477.1572899689 197801.1669702163 241020.38265773343 204463.4212550453 161140.37510558157 200000.27918424198 185536.320164342 180241.2457532874 1.156314073291034 1.0526155631172298 1.078982540745238 1.0974245442187232 1.3372099246786164 1.1343875282293212 0.8940260839416804 1.1096254819388043 1.029377706467378 1.0 17.45956966447143 -7.045128066854883 24.69140494118706 1.016937559046328 1.143413006231195 0.36147789554213317 0.08739222063159653 489.87882753932996 268031.12282411236 0.035178658708571245 0.027250570290680422 9.013053171485828e-08 7.045128066854883 0.1264754471848668 VNHEPEPAGGATPGATLPKS(ph)PSQLR ddPTM_A459_Selumetinib_30min_R1 5 VNHEPEPAGGATPGATLPKSPSQLR 25 1 O00499-6;O00499-11;O00499-2;O00499 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 VNHEPEPAGGATPGATLPKS(0.651)PS(0.349)QLR;VNHEPEPAGGATPGAT(0.005)LPKS(0.715)PS(0.28)QLR;VNHEPEPAGGATPGAT(0.002)LPKS(0.749)PS(0.249)QLR;VNHEPEPAGGAT(0.004)PGAT(0.104)LPKS(0.652)PS(0.24)QLR;VNHEPEPAGGATPGAT(0.057)LPKS(0.559)PS(0.384)QLR 164.91 1.8401e-14 128833200.0 15705.769999999999 15908.16 25265.3 26195.600000000002 19930.8 18010.760000000002 15445.42 16172.560000000001 9724.519999999999 12356.6 True False 16071.68388289147 14045.625231697064 21834.41103235881 21621.030212312853 18128.06265906853 17829.588106861655 14280.359534221023 15743.611172921532 16501.800189160527 13942.689973476534 1.1526960660722547 1.007382740232792 1.5660113703951577 1.5507072346471866 1.3001840171124739 1.278776774121726 1.024218394110953 1.1291659789374164 1.1835449415107302 1.0 13.76722130782944 -7.1337863278866465 4.736251768713303 1.0958984891045576 1.3222071035581493 0.31544133881536396 0.162347197536932 0.3307956317236365 11.308865317690552 0.07045376318053281 0.05416292402796729 7.348753365886359e-08 7.1337863278866465 0.22630861445359174 VNHEPEPAGGATPGATLPKS(ph)PSQLR ddPTM_A459_Selumetinib_30min_R2 4 VNHEPEPAGGATPGATLPKSPSQLR 25 1 O00499-6;O00499-11;O00499-2;O00499 O00499-6 BIN1 Myc box-dependent-interacting protein 1 1 VNHEPEPAGGATPGAT(0.008)LPKS(0.729)PS(0.263)QLR;VNHEPEPAGGATPGATLPKS(0.742)PS(0.258)QLR;VNHEPEPAGGATPGATLPKS(0.754)PS(0.246)QLR;VNHEPEPAGGATPGATLPKS(0.912)PS(0.087)QLR 174.77 2.1053000000000003e-17 83002100.0 192206.0 238753.0 223072.0 244415.0 247003.0 141464.0 112388.4 115906.0 86043.7 240877.0 True False 181523.95998158064 257064.5873881062 208719.79038242946 211125.25536060717 215972.2749051629 160949.3819176656 117614.68329338967 116243.2672707288 103254.84426184949 233922.255136393 0.7760012397099177 1.0989317251503907 0.8922613637626367 0.9025445451417455 0.9232651881679064 0.6880464700710963 0.5027939014388011 0.49693120136410646 0.4414066724931525 1.0 17.835669599263227 -6.879134857244561 3.178133538684779 0.5696374169727286 0.9285007614496765 0.4417910949734568 0.16330379845601367 0.19792510249262618 3.9751020858287345 0.05829165944237882 0.05088219149207866 1.3208854087899008e-07 6.879134857244561 0.3588633444769479 VNIS(ph)PTISSESK ddPTM_A459_Selumetinib_30min_R1 2 VNISPTISSESK 12 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 VNIS(0.482)PT(0.482)IS(0.035)SESK;VNIS(0.756)PT(0.22)IS(0.019)S(0.005)ESK 196.37 0.00015879 21294800.0 5148.9 5410.0 6316.799999999999 6361.3 5359.2 4739.6 4992.5 4958.7 2701.19 4166.7 True False 5268.859351984645 4776.594684959234 5459.0132556986955 5250.41837139007 4874.461306243608 4691.923927212484 4615.911705515192 4827.179167872373 4583.722142888134 4701.536532094968 1.1206675341171672 1.0159646005836354 1.1611125891360887 1.116745203519779 1.0367804807998773 0.9979554333318771 0.9817879057207661 1.0267237391264978 0.9749413009124622 1.0 12.198916612720685 -6.469866635627082 3.3188108319045657 0.9976619396513763 1.101032637783507 0.658796569278423 0.03634368260971805 0.16211716746811083 3.563385539292322 0.012218779746667794 0.01344939275499854 3.389482253353127e-07 6.469866635627082 0.10337069813213062 VNIS(ph)PTISSESK ddPTM_A459_Selumetinib_30min_R2 2 VNISPTISSESK 12 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 VNIS(0.957)PT(0.039)IS(0.003)S(0.001)ESK;VNIS(0.5)PT(0.5)IS(0.001)SESK 111.07 0.0069518 23361000.0 121097.0 118258.0 126123.0 129060.0 133691.0 110763.0 114108.0 105103.0 89678.0 120537.0 True False 114366.91352969971 127328.00834059721 118008.3834923396 111481.80535908183 116895.54136729577 126019.59784359571 119414.24810071234 105408.83232926157 107616.10581267586 117056.78361726271 0.977020809863032 1.0877456598920232 1.0081293868297998 0.9523737276396622 0.9986225296391693 1.0765680890023295 1.020139494787058 0.9004931544498427 0.9193495881840152 1.0 16.8368490176642 -7.748585545073859 24.957173044889323 0.9324410332882934 1.018663034082699 0.3758287324142089 0.04530428394782588 207.47268580801526 402833.4029713085 0.021964618733846246 0.012576540976047098 1.7840805350000527e-08 7.748585545073859 0.08622200079440556 VNISPT(ph)ISSESK ddPTM_A459_Selumetinib_30min_R1 1 VNISPTISSESK 12 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 VNIS(0.129)PT(0.38)IS(0.38)S(0.111)ESK 174.94 0.00028613 20126000.0 2820.3 2891.2 3417.7 3730.5 2561.7 2616.4 2679.2 2626.8 1333.0 2345.9 True False 2886.0075026515005 2552.696959917586 2953.595112082292 3079.0382051578526 2329.994687304869 2590.0813915011286 2477.1057869637043 2557.1287309510867 2262.003641532022 2647.0191160010527 1.090285855967484 0.9643666509571859 1.1158193358816368 1.163209659705619 0.8802334192527012 0.9784898703013744 0.9358095572448897 0.9660409006846288 0.8545475277675034 1.0 11.370152898256388 -6.268930826806112 24.998745700588287 0.9362852070703217 1.077230750622854 0.5761130386975906 0.0619188915248579 446.28515491962844 1489238.4558276217 0.01926434956961919 0.022276090586237408 5.383555234294003e-07 6.268930826806112 0.1409455435525323 VNISPT(ph)ISSESK ddPTM_A459_Selumetinib_30min_R2 1 VNISPTISSESK 12 0 Q8TAT5 Q8TAT5 NEIL3 Endonuclease 8-like 3 1 VNIS(0.224)PT(0.767)IS(0.007)S(0.002)ESK 180.95 0.00024331 11270000.0 72509.0 65147.0 71927.0 84283.0 81891.0 71499.0 71078.0 64210.0 56880.0 81003.0 True False 68479.24005652487 70143.56541937878 67299.29512819639 72803.51000371548 71603.12046517128 81347.33824670014 74383.26783838501 64396.840469462244 68257.58935998802 78664.23291893053 0.8705257461430779 0.8916830790388187 0.8555259821519321 0.9254969800410439 0.9102373188964257 1.03410832634108 0.9455792687261392 0.818629230591088 0.8677080653711154 1.0 16.263420199276027 -5.776335705412299 22.83099159383967 0.9255763559001708 0.8744887638591122 0.16408824351426898 0.057802113391217526 179.46567803922954 275059.8464120886 0.017718439379123607 0.02644329664576167 1.6736486617390428e-06 5.776335705412299 -0.051087592041058616 VNLEESSGVENS(ph)PAGARPK ddPTM_A459_Selumetinib_30min_R2 1 VNLEESSGVENSPAGARPK 19 1 Q8WVM8-2;Q8WVM8-3;Q8WVM8 Q8WVM8-2 SCFD1 Sec1 family domain-containing protein 1 1 VNLEESS(0.009)GVENS(0.991)PAGARPK 178.1 3.3513e-12 9203300.0 40349.0 41171.0 31296.0 48792.0 51835.0 37570.0 40937.0 41004.0 35497.0 42396.0 True False 38106.564109844636 44328.68331436979 29282.4494325084 42146.44542910525 45323.02388922048 42744.92647349644 42840.65161512661 41123.3148514224 42597.39186904881 41171.91732196317 0.925547474795804 1.0766727953843103 0.71122384715583 1.0236697285560277 1.100823737082628 1.0382058756028383 1.0405308861405211 0.9988195237506017 1.0346224961042858 1.0 15.329373014180941 -5.964717131481124 24.99999848326461 1.038230136735884 0.9126581866129622 0.31935658092684105 0.08636765971646022 213.59728709179294 151345.00771078095 0.023792358835606042 0.035289608831626844 1.0846331368418426e-06 5.964717131481124 -0.12557195012292177 VNLFPGLSPS(ph)ALK ddPTM_A459_Selumetinib_30min_R1 2 VNLFPGLSPSALK 13 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VNLFPGLS(0.284)PS(0.716)ALK;VNLFPGLS(0.152)PS(0.848)ALK 154.13 0.000393 165077000.0 12861.4 15132.2 15804.0 15483.1 14542.2 12965.8 13770.6 12346.4 6789.0 11755.3 True False 13161.045596072036 13360.514989231082 13657.903605158015 12779.267238782884 13226.860577633932 12835.37582400447 12731.872555226342 12018.933365240779 11520.437151058439 13264.20726131855 0.9922225532808615 1.007260722485345 1.0296811061590974 0.9634399543838658 0.9971844013781713 0.9676700289081994 0.9598668284048443 0.9061177293490223 0.8685356707788077 1.0 13.69525083466073 -7.266630673615092 1.5162479572462826 0.9175978477359306 0.9989794894399044 0.43102342188681775 0.035059943146824465 0.34343213887237195 1.539941903498898 0.019948679677268138 0.011850523828756392 5.412143789465461e-08 7.266630673615092 0.08138164170397388 VNLS(ph)PNR ddPTM_A459_Selumetinib_30min_R2 1 VNLSPNR 7 0 P35568 P35568 IRS1 Insulin receptor substrate 1 1 VNLS(1)PNR 81.525 0.042863 35517000.0 156590.0 152970.0 177270.0 203070.0 169330.0 118470.0 134470.0 146920.0 131460.0 167060.0 True False 147887.35467943625 164702.30712392594 165864.64119698232 175411.51568471047 148057.2515705933 134788.16713641537 140723.1214472501 147347.51287608477 157755.67329929743 162236.54372599235 0.9115539032266922 1.0151985695781225 1.0223630101311676 1.0812084112255858 0.9126011203779896 0.8308126149683291 0.8673947201742839 0.9082264050505523 0.972380634326981 1.0 17.307739297161383 -6.382651973996483 7.984704639254995 0.9032568095848795 1.0089693064829954 0.3556056129136852 0.05969917660440388 0.2901141473548715 17.765907515712914 0.018994607819054286 0.021532197746365195 4.1433157035309686e-07 6.382651973996483 0.1057124968981159 VNNGNTAPEDS(ph)SPAK ddPTM_A459_Selumetinib_30min_R1 2 VNNGNTAPEDSSPAK 15 0 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 VNNGNTAPEDS(0.856)S(0.144)PAK;VNNGNTAPEDS(0.97)S(0.03)PAK 184.0 2.1012e-05 12855300.0 6774.5 6831.700000000001 8412.2 7538.2 6160.700000000001 6790.9 6971.6 7453.0 4530.5 7828.2 True False 6932.332669117674 6031.841388028839 7269.869444907006 6221.794879539187 5603.465772759929 6722.589711643863 6445.726599132639 7255.322229244114 7687.927605371965 8833.02572312521 0.7848197080382721 0.6828737487129964 0.8230327492281836 0.7043786664461172 0.6343767071899081 0.7610743953845688 0.7297303099953023 0.8213858372731094 0.8703617363237907 1.0 13.108691997509887 -8.381263228053427 1.1443427082607798 0.9967947099577023 0.726819978947738 0.7383803451278447 0.05099048820375456 0.23345322042453634 0.6519480536642921 0.04823806951157321 0.015579035515586618 4.1565860137653284e-09 8.381263228053427 -0.2699747310099643 VNNGNTAPEDS(ph)SPAK ddPTM_A459_Selumetinib_30min_R2 2 VNNGNTAPEDSSPAK 15 0 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 VNNGNTAPEDS(0.726)S(0.274)PAK;VNNGNTAPEDS(0.5)S(0.5)PAK 276.63 5.093399999999999e-47 21512000.0 106712.0 79683.0 86999.0 100213.0 99074.0 85447.0 104051.0 98350.0 72533.0 84875.0 True False 100781.37424198221 85794.42987877216 81401.57905734923 86563.81652293245 86627.43838720223 97216.54863936259 108889.57767314516 98636.18221728093 87041.6267413503 82424.4382182665 1.2227122977181242 1.0408858311121474 0.9875903411290634 1.0502202792538853 1.0509921603324228 1.1794626780703727 1.32108364978839 1.1966861327715022 1.0560172276923152 1.0 16.330784528475952 -6.763406579766426 24.984662516978503 1.173594943488967 1.0631055014666349 0.11813688651155307 0.09912801030489302 82.26967770212609 1044866.1180982135 0.03452353953116526 0.03198818939043855 1.7242229453521488e-07 6.763406579766426 -0.11048944202233213 VNNGNTAPEDS(ph)SPAKK ddPTM_A459_Selumetinib_30min_R2 1 VNNGNTAPEDSSPAKK 16 1 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 VNNGNTAPEDS(0.5)S(0.5)PAKK 113.81 0.0011335000000000002 12744000.0 69603.0 59169.0 53133.0 59602.0 62221.0 52627.0 84749.0 66511.0 43494.0 61566.0 True False 65734.74390288522 63707.07204167847 49714.48062683631 51484.104780815156 54404.24171720242 59875.891549659274 88689.99642695762 66704.5359985112 52194.015323898086 59788.42961232154 1.0994559370286292 1.0655418189567125 0.8315067137436717 0.8611048176820657 0.9099459890478623 1.0014628572435311 1.4833973228940585 1.1156763345522684 0.8729785288279531 1.0 15.867578697484381 -7.0172731757800895 24.95295710721604 1.144049500407581 0.9486113701004428 0.17678955179648648 0.16415981041594674 1132.1300914188078 1635481.003583106 0.06442218899388398 0.0511031644533649 9.610076043769054e-08 7.0172731757800895 -0.1954381303071382 VNNGNTAPEDSS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 1 VNNGNTAPEDSSPAK 15 0 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 VNNGNTAPEDS(0.448)S(0.552)PAK 176.56 1.9311e-05 8508700.0 3304.2 3169.5 3623.7 3889.4 2849.1 3260.7 3397.3 3466.9 2056.6 3249.1 True False 3381.181431146005 2798.413466539426 3131.621443559295 3210.1893030802707 2591.39940804946 3227.9003184787193 3141.03892581808 3374.9465499216985 3489.8999918790355 3666.153633914072 0.9222694324286066 0.7633104735853019 0.8541980932249973 0.8756286898028867 0.7068441933468077 0.8804596426671123 0.8567668568937283 0.9205687723235226 0.9519240982143827 1.0 11.840051529416511 -7.979171724252682 1.1836855210508468 0.9933536487345455 0.8269960480015481 0.5035575868852169 0.05783065330253543 0.37751344270353226 0.9584898837775297 0.050824532560914855 0.017896887305131583 1.0491275114274809e-08 7.979171724252682 -0.16635760073299732 VNNGNTAPEDSS(ph)PAKK ddPTM_A459_Selumetinib_30min_R1 2 VNNGNTAPEDSSPAKK 16 1 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 VNNGNTAPEDS(0.405)S(0.595)PAKK;VNNGNTAPEDS(0.162)S(0.838)PAKK 136.85 0.00020986 29879000.0 8780.8 8136.1 11626.1 10476.599999999999 8844.3 8833.8 9070.8 9220.2 5803.200000000001 9896.7 True False 8985.37555553745 7183.52162962973 10047.339477596026 8647.05848013852 8044.334626587991 8744.93999244865 8386.58225305702 8975.650344569516 9847.60655104174 11167.037847021447 0.8046337514593536 0.6432790618280004 0.8997318371474782 0.7743377069725724 0.7203642305854309 0.7831029241815602 0.7510122530205223 0.8037628659925753 0.8818459009403612 1.0 13.4469589288307 -8.500441988434105 1.6063442207662253 0.9991339530752947 0.7668992017507816 0.5873073016984179 0.06112799587060472 0.2663731532985152 1.524706027058657 0.05655251014803228 0.016487327946158304 3.1590609967640615e-09 8.500441988434105 -0.2322347513245131 VNNGNTAPEDSS(ph)PAKK ddPTM_A459_Selumetinib_30min_R2 3 VNNGNTAPEDSSPAKK 16 1 E9PJ27;G3V167;Q9UGN5-2;Q9UGN5 E9PJ27 PARP2 Poly [ADP-ribose] polymerase 2 1 VNNGNTAPEDS(0.375)S(0.625)PAKK;VNNGNTAPEDS(0.196)S(0.804)PAKK;VNNGNTAPEDS(0.317)S(0.683)PAKK 115.63 0.0010187999999999998 61823000.0 202283.0 149605.0 170146.0 191551.0 172487.0 138406.0 200987.0 191153.0 128594.0 148298.0 True False 191040.9206630078 161079.2224441057 159198.9916009582 165461.42335609428 150817.64100665503 157470.170175426 210333.29374818527 191709.22358291724 154316.3932165668 144016.25141552291 1.3265233526444662 1.118479483119942 1.1054237979131207 1.1489079998249412 1.0472265423122866 1.0934194483446535 1.4604830474397024 1.3311638214342087 1.0715206908929007 1.0 17.135872095227093 VNPHKVS(ph)PASSVDSNIPSSQGYKK ddPTM_A459_Selumetinib_30min_R1 1 VNPHKVSPASSVDSNIPSSQGYKK 24 2 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 VNPHKVS(0.866)PAS(0.083)S(0.025)VDS(0.022)NIPS(0.001)S(0.001)QGY(0.001)KK 45.363 0.027678 12396000.0 1199.8 1000.3 1988.6 2291.4 1451.5 1322.1 1276.0 1505.4 861.12 1112.2 True False 1227.7530055955995 883.1844109731463 1718.5590425979021 1891.2500049051612 1320.212081283138 1308.800874370753 1179.750292686506 1465.4719017716482 1461.257746283613 1254.9617037454166 0.9783191008390032 0.7037540734010401 1.3694115425744748 1.5070181020351063 1.0519939192909096 1.042901046673101 0.940068759999255 1.1677423282303887 1.1643843329421995 1.0 10.293427624408205 -5.25321722003635 24.919602280122756 1.1585815820758687 0.8410365871651576 0.3441111552079559 0.17358191292594044 699.8526560850801 2121090.58668119 0.047990841431012725 0.1223869466561748 5.581909358739706e-06 5.25321722003635 -0.3175449949107111 VNPHKVS(ph)PASSVDSNIPSSQGYKK ddPTM_A459_Selumetinib_30min_R2 1 VNPHKVSPASSVDSNIPSSQGYKK 24 2 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 VNPHKVS(0.901)PAS(0.047)S(0.047)VDS(0.002)NIPS(0.001)S(0.001)QGY(0.001)KK 45.784 0.026644 9571300.0 61399.0 59587.0 61545.0 80513.0 63087.0 48843.0 39912.0 43438.0 32884.0 66705.0 True False 57986.68937967112 64157.13129759665 57585.26170512939 69546.99050732798 55161.44705506419 55570.67989739123 41767.98708412763 43564.397388451966 39461.71885572869 64779.053329596114 0.8951456743993246 0.9903993343521844 0.8889487997321499 1.0736030697063845 0.8515321576930509 0.8578495214285915 0.6447761264989768 0.6725074719260887 0.6091740590117501 1.0 15.983239764529161 -6.902980523206872 2.0764906378307235 0.7066799414659916 0.954475292974076 0.4103566169771875 0.11580042771827952 0.26805669703380086 2.3562993770044445 0.04591855697273862 0.03833472552147749 1.2503151018086477e-07 6.902980523206872 0.2477953515080844 VNPHKVSPAS(ph)SVDSNIPSSQGYK ddPTM_A459_Selumetinib_30min_R1 2 VNPHKVSPASSVDSNIPSSQGYK 23 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 VNPHKVS(0.111)PAS(0.674)S(0.209)VDS(0.006)NIPSSQGYK;VNPHKVS(0.068)PAS(0.684)S(0.245)VDS(0.002)NIPSSQGYK 121.14 5.8107e-06 36486000.0 6353.2 8918.8 7035.4 7131.1 7048.299999999999 7051.6 7257.3 6883.6 3332.3 6662.4 True False 6501.217198824768 7874.582749762363 6080.03132268595 5885.787252325741 6410.782509478435 6980.667306340527 6709.876018114251 6701.024566915979 5654.669718437475 7517.583937271587 0.8648014113407164 1.0474885036827861 0.8087746506615823 0.7829360205935942 0.8527716568210542 0.9285785652130772 0.8925575123740509 0.8913800794019511 0.752192428527744 1.0 12.876053355902924 -5.27701954294292 24.834664324553398 0.8598498792853989 0.9561449774369374 0.17661028890146035 0.07954971831895616 1035.406447680686 1650429.687140928 0.02030501003100048 0.04250672472114073 5.284214726495793e-06 5.27701954294292 0.09629509815153847 VNPHKVSPAS(ph)SVDSNIPSSQGYK ddPTM_A459_Selumetinib_30min_R2 1 VNPHKVSPASSVDSNIPSSQGYK 23 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 VNPHKVS(0.017)PAS(0.361)S(0.361)VDS(0.261)NIPSSQGYK 68.639 0.0013364000000000002 20595000.0 124960.0 94252.0 122860.0 129510.0 141280.0 95025.0 115870.0 114740.0 90881.0 125680.0 True False 118015.22345451414 101480.82533205365 114955.32135985361 111870.51458278862 123531.14334077483 108113.83119893537 121258.18459204937 115073.87440377043 109059.7394273045 122051.29184414397 0.966931375091189 0.8314604769742362 0.9418607506969143 0.9165860753497315 1.0121248327180394 0.8858065290860965 0.9935018528676667 0.942832088583843 0.8935566168899768 1.0 16.89712803975069 -5.485335408030808 24.966264774516826 0.9471514076094142 0.8960620780358874 0.1293076666602021 0.05093839353068571 980.5160257891745 652040.0715279699 0.012405346723719266 0.02581275276980014 3.2708798544640397e-06 5.485335408030808 -0.05108932957352674 VNPHKVSPASSVDS(ph)NIPSSQGYK ddPTM_A459_Selumetinib_30min_R2 1 VNPHKVSPASSVDSNIPSSQGYK 23 1 Q9UHB7;Q9UHB7-2 Q9UHB7 AFF4 AF4/FMR2 family member 4 1 VNPHKVS(0.035)PAS(0.035)S(0.035)VDS(0.894)NIPSSQGYK 56.74800000000001 0.007317399999999998 20244000.0 63258.0 52446.0 65449.0 72623.0 74206.0 56907.0 54281.0 52715.0 48716.0 58252.0 True False 59742.3736018378 56468.43955953064 61238.08259548321 62731.6221183373 64883.57886994299 64745.42269968756 56805.17405576096 52868.39192256196 58460.561238769 56570.11340312761 1.0560766102076578 0.998202693304282 1.0825165252735294 1.1089180902166804 1.146958614128494 1.1445164028274328 1.0041552091465378 0.9345640081329413 1.033417784089803 1.0 15.787752442628818 -7.4142518947012865 6.432464958907981 0.9845018539135197 1.0882481725581457 0.5117073746262942 0.0462338340537771 0.21571975974012597 11.041632346820801 0.021898876942379776 0.014612823588971806 3.852548415820506e-08 7.4142518947012865 0.10374631864462591 VNPSVNPSIS(ph)PAHGVAR ddPTM_A459_Selumetinib_30min_R2 1 VNPSVNPSISPAHGVAR 17 0 Q15788-2;Q15788-3;Q15788;B5MCN7 Q15788-2 NCOA1 Nuclear receptor coactivator 1 1 VNPS(0.004)VNPS(0.078)IS(0.918)PAHGVAR 136.85 0.00051295 5027000.0 12747.0 14928.0 14829.0 17215.0 15964.0 11289.0 14000.0 14417.0 11941.0 12600.0 True False 12038.57277028402 16072.929598914581 13874.91828459443 14870.287302468589 13958.459600029235 12843.957278661212 14651.02774047371 14458.951083137166 14329.533659416635 12236.205261268422 0.9838485472608102 1.3135550814753527 1.133923302881578 1.2152695206526074 1.1407506904295166 1.049668341157738 1.197350602383975 1.181653198390228 1.1710766004207431 1.0 13.578868592843774 -6.500906066021148 23.899639630783163 1.131592733941715 1.171455501986361 0.029872641233799624 0.09546432370630648 1782.5338508591283 1938859.8509281515 0.02847943640322094 0.031971842253082375 3.1556870962184213e-07 6.500906066021148 0.03986276804464617 VNPVTSLSENYT(ph)CSDSEESSEKDK ddPTM_A459_Selumetinib_30min_R1 1 VNPVTSLSENYTCSDSEESSEKDK 24 1 Q14432 Q14432 PDE3A cGMP-inhibited 3,5-cyclic phosphodiesterase A 1 VNPVTSLS(0.002)ENY(0.038)T(0.479)CS(0.479)DS(0.001)EESSEKDK 79.455 0.00039257 10755000.0 1912.3 2371.4 1448.4 1890.3 2098.8 1852.0 2432.9 2103.4 1300.3 2271.3 True False 1956.852869311939 2093.7553855660485 1251.7152354917025 1560.1945903256642 1908.9639105732372 1833.3705614814576 2249.3843942609724 2047.6109991938927 2206.514129845528 2562.843479335518 0.7635475537582586 0.8169657657395868 0.48840877157907486 0.60877482487935 0.7448616842836552 0.7153657943858535 0.8776908977852139 0.7989606137495324 0.8609632806829164 1.0 11.323529656197623 -7.886685362191173 0.6393454426982088 0.9793875614050664 0.6705679502945977 0.540022423171139 0.09217307566908432 0.6105316052723336 0.5229715265223359 0.09568301342326432 0.048571151623332504 1.298119392356659e-08 7.886685362191173 -0.30881961111046874 VNPVTSLSENYTCS(ph)DSEESSEKDK ddPTM_A459_Selumetinib_30min_R1 1 VNPVTSLSENYTCSDSEESSEKDK 24 1 Q14432 Q14432 PDE3A cGMP-inhibited 3,5-cyclic phosphodiesterase A 1 VNPVTSLS(0.003)ENY(0.251)T(0.202)CS(0.536)DS(0.005)EES(0.002)S(0.001)EKDK 79.455 0.00015596 5233000.0 856.08 1092.9 1020.1 1046.6 1348.5 959.11 1224.5 900.33 531.61 675.36 True False 876.0249983582934 964.9427599245747 881.5760230082067 863.830957115188 1226.5284130970122 949.4622242022039 1132.134979149395 876.450323716001 902.1033427418142 762.0490345634815 1.1495651311468424 1.2662475984597437 1.1568494716526907 1.1335634820533687 1.6095137680997058 1.24593324200729 1.4856458414095448 1.1501232649918007 1.1837864780690377 1.0 9.573740021673833 -8.490991948559104 1.6643762996597595 1.0078439345642274 1.2871588185329494 0.24956847139142257 0.14823933894017582 0.5375077010058742 3.3014616816295264 0.14355442351660047 0.041594195470288066 3.228553975732525e-09 8.490991948559104 0.27931488396872206 VNPVTSLSENYTCS(ph)DSEESSEKDK ddPTM_A459_Selumetinib_30min_R2 2 VNPVTSLSENYTCSDSEESSEKDK 24 1 Q14432 Q14432 PDE3A cGMP-inhibited 3,5-cyclic phosphodiesterase A 1 VNPVTSLS(0.014)ENY(0.025)T(0.1)CS(0.861)DSEESSEKDK;VNPVTSLS(0.001)ENY(0.019)T(0.261)CS(0.713)DS(0.006)EESSEKDK 106.42 3.1692e-07 20899000.0 119569.0 94852.0 106930.0 112170.0 107693.0 85901.0 108372.0 117890.0 71399.0 97560.0 True False 112923.8336526312 102126.8434027493 100050.24021658141 96892.25249595688 94163.64255236457 97733.08301836083 113411.5127350442 118233.04038225979 85680.79505474315 94743.18930867848 1.191893944848312 1.0779333495942856 1.0560151177792028 1.0226830361418027 0.9938829718469185 1.0315578748351093 1.1970413236305917 1.2479318169990044 0.9043478025168695 1.0 16.53173461725268 VNQIGSVTESLQACK ddPTM_A459_Selumetinib_30min_R1 2 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 0 ; 277.82 6.765599999999998e-54 30392000.0 3609.5 3929.2 4301.9 4316.0 4189.9 3774.7999999999997 3544.3999999999996 3599.9 2591.3 2985.6 False True 3693.5943271356186 3469.1674373644764 3717.7256086452335 3562.291621354051 3810.9242847869236 3736.8289392441748 3277.043054387189 3504.418957876812 4397.246838936182 3368.830842206718 1.096402431627041 1.0297838033007423 1.103565534388772 1.057426682492793 1.1312305257483979 1.109236145794843 0.9727538151605724 1.0402478254388334 1.3052738605467678 1.0 11.718032273455265 VNQIGSVTESLQACK ddPTM_A459_Selumetinib_30min_R2 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 0 206.66 2.7694e-05 10220000.0 25324.0 20471.0 21543.0 19946.0 21979.0 19893.0 21173.0 20985.0 16987.0 23435.0 False True 23916.593460004107 22041.05987536042 20156.946834244904 17229.32039123082 19217.80152524697 22633.080179325665 22157.586453503583 21046.062875746233 20384.874656436674 22758.37065855758 1.0508921670546312 0.9684814526505906 0.8856937579872621 0.7570542131385961 0.8444278289325037 0.9944947517943337 0.9736016161232488 0.9247614071982132 0.8957088783845594 1.0 14.47410965393552 -6.768278396730917 24.99904048111506 0.9540039290502426 0.8961598705960931 0.11492330224288627 0.07726660788671173 418.91339584124967 1531266.8682637564 0.030157158857439827 0.027174411742863877 1.70498908577852e-07 6.768278396730917 -0.057844058454149416 VNQSALEAVTPS(ph)PSFQQR ddPTM_A459_Selumetinib_30min_R1 3 VNQSALEAVTPSPSFQQR 18 0 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 VNQSALEAVT(0.011)PS(0.98)PS(0.01)FQQR;VNQSALEAVT(0.011)PS(0.987)PS(0.003)FQQR;VNQSALEAVT(0.001)PS(0.998)PS(0.001)FQQR 215.64 6.1014e-13 99190000.0 6896.5 9187.9 8946.8 9628.1 8895.3 7743.1 8445.4 7800.5 4710.51 7728.200000000001 True False 7057.175031746996 8112.176396661177 7731.8737012546035 7946.733076820892 8090.72168559277 7665.211444172288 7808.356678569453 7593.605400405036 7993.3914279617475 8720.189749042735 0.8092914529207008 0.9302752153474295 0.8866634699208668 0.9113027704119914 0.9278148662396865 0.879018882016156 0.8954342627035864 0.8708073584337577 0.9166533823233867 1.0 13.090143812671695 -8.605746946577902 6.408519942184473 0.9999991961062039 0.8921375774453396 0.5111979376547711 0.03259854278749154 1.0030358076169532 77.22478369178371 0.029791397465987697 0.007714734694920577 2.47886601521796e-09 8.605746946577902 -0.1078616186608643 VNQSALEAVTPS(ph)PSFQQR ddPTM_A459_Selumetinib_30min_R2 4 VNQSALEAVTPSPSFQQR 18 0 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 VNQSALEAVT(0.048)PS(0.806)PS(0.146)FQQR;VNQSALEAVTPS(0.875)PS(0.125)FQQR;VNQSALEAVT(0.002)PS(0.926)PS(0.072)FQQR;VNQS(0.002)ALEAVT(0.184)PS(0.788)PS(0.026)FQQR 172.3 5.2168e-08 129271000.0 145293.0 121578.0 148161.0 153540.0 149974.0 104299.0 107166.0 124387.0 94560.0 123611.0 True False 137218.196713962 130902.64166511495 138628.48256549996 132627.58712872665 131132.9253354288 118665.2405179455 112149.43134540056 124748.94557662349 113474.64222715296 120042.02925005156 1.1430846143739533 1.090473415710429 1.154832881712889 1.1048429284085073 1.0923917744032343 0.9885307775892545 0.9342513788382363 1.039210569464527 0.9452909363168251 1.0 16.873180086724915 -6.701414230715992 3.2269025348006153 0.9793761640547606 1.1212527232017304 0.8231755925634854 0.03170539383002653 0.09665304679589606 2.040969638415679 0.010836079988260007 0.010449977458793266 1.9887755370338038e-07 6.701414230715992 0.14187655914696984 VNS(ph)GDTEVGSSLLR ddPTM_A459_Selumetinib_30min_R2 1 VNSGDTEVGSSLLR 14 0 A0A499FJI4;O75592-2;O75592 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 VNS(0.998)GDT(0.001)EVGSSLLR 145.33 0.00051905 4511500.0 9717.7 9777.3 9515.4 10612.0 8389.4 8533.6 11750.0 11718.0 11444.0 15624.0 True False 9177.629137035296 10527.187471025412 8903.189523584178 9166.627293278923 7335.448569812411 9709.02593969203 12296.398282183298 11752.097439980676 13733.11977207636 15172.894523972835 0.6048700280974633 0.6938153728276889 0.5867825357592342 0.604144929551567 0.48345742852311835 0.6398927985923837 0.8104187544937628 0.7745455174299555 0.9051087615733661 1.0 13.889208713455924 -7.835624151195115 0.9815966885558854 0.9774135380097273 0.5973754369091026 0.8372157653139362 0.06123577046376263 0.22616462761505593 0.3967992803786433 0.0596711023847026 0.02365040640932439 1.4600772993899712e-08 7.835624151195115 -0.38003810110062475 VNS(ph)PGTLAR ddPTM_A459_Selumetinib_30min_R2 1 VNSPGTLAR 9 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6;P53814-2 A0A087WVP4 SMTN Smoothelin 1 VNS(0.904)PGT(0.096)LAR 81.92 0.042653 9048300.0 33843.0 36133.0 40011.0 38438.0 43097.0 26597.0 35338.0 29664.0 24860.0 38220.0 True False 31962.1415442631 38904.28491409301 37436.735820682945 33202.67809075151 37682.76956793162 30260.495326472876 36981.28702091858 29750.317328860434 29832.69464643644 37116.489292514234 0.8611305151295471 1.0481671530809178 1.008628147065442 0.8945533029560511 1.0152568383004799 0.8152844167989752 0.9963573529131452 0.8015390974722538 0.8037585239090268 1.0 15.179772637433953 -6.7551990381283575 24.999979559431353 0.8780446628521889 0.9685864682477964 0.18959678373171884 0.08445332167665658 236.24567072746356 946443.81692821 0.027499835779815796 0.02684717090519542 1.75711813824076e-07 6.7551990381283575 0.09054180539560752 VNSGDT(ph)EVGSSLLR ddPTM_A459_Selumetinib_30min_R1 2 VNSGDTEVGSSLLR 14 0 A0A499FJI4;O75592-2;O75592 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 VNS(0.16)GDT(0.537)EVGS(0.282)S(0.02)LLR;VNS(0.093)GDT(0.907)EVGSSLLR 195.89 0.00028803 36233000.0 2228.2 2763.2 2169.2799999999997 2342.2200000000003 2240.19 2242.1099999999997 2434.22 3041.83 1664.45 1904.1100000000001 True False 2280.1127246775404 2439.6832594231723 1874.7036910021004 1933.1952459147105 2037.565210037669 2219.5564090729986 2250.604825598235 2961.1507871436497 2824.4500833818274 2148.521066102036 1.0612475533294374 1.1355174952272535 0.8725554152481688 0.8997795164382627 0.9483571011637 1.033062437269856 1.0475135017788795 1.3782274858100092 1.3146019966683866 1.0 11.069128207369443 -7.620703153549826 5.806965884322034 1.2580008954489788 0.9909026051713026 0.45167890665482013 0.11678152829992924 0.17195701448633932 8.48122749195133 0.05708309052363546 0.032386622648298447 2.3949521809324892e-08 7.620703153549826 -0.2670982902776762 VNSPGT(ph)LAR ddPTM_A459_Selumetinib_30min_R2 3 VNSPGTLAR 9 0 A0A087WVP4;A0A087X1R1;P53814-5;P53814;P53814-6;P53814-2 A0A087WVP4 SMTN Smoothelin 1 VNS(0.122)PGT(0.878)LAR;VNS(0.082)PGT(0.918)LAR;VNS(0.323)PGT(0.677)LAR 115.91 0.018745 25317900.0 135147.0 140238.0 166202.0 158697.0 169027.0 122878.0 133646.0 129899.0 106541.0 146190.0 True False 127636.07077630595 150993.80366375783 155508.74426705498 137082.194832405 147792.31713944755 139803.3291245753 139860.80381452493 130276.98458406287 127852.17700426307 141969.11485276415 0.8990411112211063 1.0635679726562581 1.0953702460449426 0.9655775833678517 1.0410173881320781 0.9847446697795152 0.9851495091701759 0.9176431417437013 0.900563317147242 1.0 17.115217582369965 -7.426698951849512 1.9665201952927216 0.9330436945862493 1.0162125319610003 0.2146572633240963 0.05684756748501814 0.45823476808822705 3.466157444122103 0.0319620704859562 0.017693071906145923 3.74370007513379e-08 7.426698951849512 0.083168837374751 VNVALVYPPTPTVIS(ph)PCSK ddPTM_A459_Selumetinib_30min_R2 2 VNVALVYPPTPTVISPCSK 19 0 Q9Y4C4 Q9Y4C4 MFHAS1 Malignant fibrous histiocytoma-amplified sequence 1 1 VNVALVYPPT(0.039)PT(0.266)VIS(0.52)PCS(0.175)K;VNVALVYPPT(0.001)PT(0.004)VIS(0.851)PCS(0.143)K 122.19 0.00043338 9019000.0 112862.0 82778.0 106042.0 118786.0 112622.0 109558.0 101856.0 116253.0 94939.0 105277.0 True False 106589.58186238291 89126.80642677848 99219.37316979964 102607.14188272055 98473.41750654562 124648.62003149657 106592.50582383497 116591.27698327985 113929.45281729805 102237.37946750423 1.0425695808866269 0.8717634087550836 0.9704804024377028 1.0036167047428466 0.963184091957727 1.2192078932453043 1.04259818061666 1.1403977448418263 1.1143620211188032 1.0 16.641563237374967 -6.726947904574046 24.997587287335655 1.1082933492160354 0.9667056087765933 0.49137986495063146 0.06750653086249814 141.3697169930835 102456.91426626449 0.02104263272978598 0.021041720619977927 1.8752194349323526e-07 6.726947904574046 -0.1415877404394421 VNVGAGSHPNK ddPTM_A459_Selumetinib_30min_R2 2 VNVGAGSHPNK 11 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 100.09 0.023343 13998700.0 249990.0 183463.0 261300.0 287830.0 336600.0 219889.0 247950.0 247570.0 208742.0 220000.0 False True 236096.5565892603 197534.02217347687 244488.24248192873 248627.05746555523 294313.2987578204 250176.713796398 259480.1663036039 248290.38771258 250496.23273879435 213648.02837135372 1.1050724801395664 0.9245768551167335 1.1443505673591796 1.16372268614341 1.3775615015096596 1.170976000590802 1.2145216985227065 1.16214687121293 1.1724715395144798 1.0 17.70487647775588 -5.454672424712422 4.857504707852862 1.193875001074087 1.0152444403567038 0.3102309741833743 0.09548374387002108 0.2185448455823644 9.852669336910399 0.024559202492815332 0.05190534779571445 3.5101653535994696e-06 5.454672424712422 -0.17863056071738326 VNVTVDYIRPAS(ph)PATETVPAFSER ddPTM_A459_Selumetinib_30min_R1 4 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 VNVTVDY(0.003)IRPAS(0.529)PAT(0.159)ET(0.308)VPAFS(0.001)ER;VNVTVDYIRPAS(0.722)PAT(0.115)ET(0.162)VPAFSER;VNVT(0.003)VDY(0.024)IRPAS(0.781)PAT(0.08)ET(0.105)VPAFS(0.007)ER;VNVT(0.004)VDY(0.05)IRPAS(0.507)PAT(0.179)ET(0.238)VPAFS(0.022)ER 93.384 1.2724e-05 85160000.0 4788.56 5289.13 4665.7 5920.5 4785.76 4480.219999999999 5328.200000000001 5070.79 2691.41 4615.57 True False 4900.124131084232 4669.876200750175 4032.1235668555905 4886.595816549276 4352.8888529945525 4435.153054514286 4926.289584241569 4936.296176952738 4567.126197191074 5208.023368959024 0.9408798278997864 0.8966695941849404 0.7742138007459687 0.9382822369182273 0.8358044011358967 0.8516000678777256 0.9459038939040384 0.9478252740519868 0.8769404193560576 1.0 12.346520206707428 -7.26752189275246 24.77840578464441 0.9383195069767498 0.8707872641657391 0.28688160744134383 0.05364380311812354 619.9493383331237 2525481.284162748 0.021741423889307526 0.015075760740227725 5.401048874312614e-08 7.26752189275246 -0.06753224281101067 VNVTVDYIRPASPAT(ph)ETVPAFSER ddPTM_A459_Selumetinib_30min_R2 2 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 VNVT(0.002)VDY(0.004)IRPAS(0.276)PAT(0.513)ET(0.202)VPAFS(0.004)ER;VNVT(0.013)VDY(0.06)IRPAS(0.251)PAT(0.406)ET(0.266)VPAFS(0.005)ER 67.758 0.0030436 43167000.0 46825.0 40926.0 50935.0 48693.0 62539.0 42597.0 41893.0 47493.0 43243.0 46225.0 True False 44222.65395532665 44064.892602168926 47657.897553834846 42060.92939988981 54682.29171424634 48464.350092933935 43841.107509404676 47631.19676711058 51892.80831037211 44890.36414302643 0.9851257569314347 0.9816113868395576 1.0616509458909866 0.9369701093508245 1.2181298316053213 1.079615882342151 0.976626239201832 1.0610561459325993 1.1559899167900487 1.0 15.454118178748054 -6.197461001989696 24.999781314201005 1.079580315276944 0.9956669817653062 0.27968874686684375 0.07100570953746088 317.69194995434435 124138.6488284328 0.021252430148068522 0.027436792633561722 6.346568882230928e-07 6.197461001989696 -0.08391333351163788 VPAAFPTKVPVPGPGS(ph)GGNGPER ddPTM_A459_Selumetinib_30min_R1 2 VPAAFPTKVPVPGPGSGGNGPER 23 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 VPAAFPTKVPVPGPGS(1)GGNGPER;VPAAFPTKVPVPGPGS(1)GGNGPER 113.87 6.4733e-06 86953000.0 2446.3999999999996 2879.2 3874.8 4222.1 3896.5 2947.4 2800.5 3120.2 1403.69 2222.79 True False 2503.396360134249 2542.101925496235 3348.6234427528652 3484.789493632752 3544.062262982948 2917.7518320250797 2589.2560303045148 3037.4421601620156 2381.9594085386984 2508.1067483081038 0.9981219347314334 1.0135541189429291 1.335119984431185 1.3894103574273664 1.4130428321576305 1.1633284085668645 1.032354795923719 1.2110497937183042 0.9497041583838085 1.0 11.292383037099226 -7.003781327592294 24.909929979102447 1.0704327830089482 1.2381101657867764 0.25153498970841925 0.14549333813436102 260.16894358226904 1713903.0590373836 0.057702706111616035 0.049805378834206174 9.913309661158318e-08 7.003781327592294 0.16767738277782818 VPAAFPTKVPVPGPGS(ph)GGNGPER ddPTM_A459_Selumetinib_30min_R2 2 VPAAFPTKVPVPGPGSGGNGPER 23 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 VPAAFPT(0.026)KVPVPGPGS(0.974)GGNGPER;VPAAFPTKVPVPGPGS(1)GGNGPER 96.312 3.9919e-05 31687000.0 104130.0 111300.0 127394.0 132892.0 125653.0 64451.0 66817.0 62636.0 49481.0 101318.0 True False 98342.87146541732 119836.35211409362 119197.60873609952 114791.88034851324 109867.34678792741 73328.54022207389 69924.12289537376 62818.260390052026 59378.58261465493 98392.68608422187 0.9994937162426696 1.2179396343699416 1.2114478573546523 1.166670866676554 1.116621073784727 0.7452641363943083 0.7106638275483232 0.6384444097428242 0.6034857363669107 1.0 16.586263457896592 -6.758495618871131 4.215980387877986 0.7098985381623037 1.1568347381180808 0.7530899557781382 0.11496919589923948 0.0926090783432481 3.81034402005005 0.03907591579360537 0.03661998393312584 1.7438309490077436e-07 6.758495618871131 0.44693619995577705 VPADTEVVCAPPTAYIDFAR ddPTM_A459_Selumetinib_30min_R1 1 VPADTEVVCAPPTAYIDFAR 20 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 135.91 0.001483 14063000.0 330.05 348.66 566.82 549.33 390.04 318.01 340.53 369.4 315.35 553.28 False True 337.73952283449523 307.83872511236353 489.84895731939207 453.39982770121014 354.76095086715486 314.8111081299778 314.8435479377241 359.6023120196935 535.1259177472791 624.2988774035814 0.5409901171681295 0.4930951123805394 0.7846385362034322 0.7262544337527415 0.568254987647235 0.5042634538111886 0.5043154157943356 0.5760098648827565 0.8571630305869412 1.0 9.286093061358425 -8.411464514754208 3.1624611192293175 0.9952883871881439 0.5887271605481307 0.6975930718865904 0.09204780033461941 0.14461203750180796 2.697807956698581 0.09865360364595448 0.026425429662401165 3.877354282241654e-09 8.411464514754208 -0.40656122664001326 VPAINVNDS(ph)VTK ddPTM_A459_Selumetinib_30min_R2 2 VPAINVNDSVTK 12 0 P23526-2;P23526 P23526-2 AHCY Adenosylhomocysteinase 1 VPAINVNDS(0.997)VT(0.003)K;VPAINVNDS(0.791)VT(0.209)K 155.09 0.00057981 3044300.0 40337.0 35448.0 42298.0 40331.0 38806.0 31701.0 31798.0 31687.0 27944.2 43328.0 True False 38095.23102180484 38166.747616715154 39576.59273058028 34837.84822514439 33930.84334995831 36067.52499697396 33276.67000654164 31779.203923934758 33533.820826184594 42077.00806033636 0.9053692925879652 0.9070689522882881 0.9405752584363745 0.827954501308378 0.8063986702976398 0.8571789359465602 0.7908516204104752 0.7552629188454878 0.7969630535065313 1.0 15.36074450314413 -5.786458760507027 11.696328072154637 0.8213664219994066 0.916602557175121 0.25629798685672367 0.06336239755620691 0.7482627341053973 347.3629197508063 0.0170238370976846 0.02550568843706067 1.6350884075705737e-06 5.786458760507027 0.09523613517571439 VPAPFS(ph)PPPSKPR ddPTM_A459_Selumetinib_30min_R1 1 VPAPFSPPPSKPR 13 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 VPAPFS(0.998)PPPS(0.002)KPR 95.755 0.0081054 17429000.0 4342.8 4679.5 4533.1 4832.4 4676.9 3873.0 4449.1 4759.3 2632.7 4494.7 True False 4443.978790382202 4131.621964559471 3917.5299185359295 3988.512055382606 4253.87522077376 3834.0411364026395 4113.500805009042 4633.067903614854 4467.499615199815 5071.638527085525 0.8762412318324241 0.8146522948144245 0.7724387094257648 0.7864346076877544 0.8387575727362213 0.7559768141847275 0.8110792563469447 0.9135248655580545 0.8808789489512602 1.0 12.308236208024846 -8.338003420214257 1.0127352973642467 0.9928339466642137 0.8043146086885556 0.6951790737510426 0.03892824758353605 0.28036649218536297 0.6122137850688045 0.03727709730844214 0.012675589044679756 4.591943965132188e-09 8.338003420214257 -0.188519337975658 VPAPFS(ph)PPPSKPR ddPTM_A459_Selumetinib_30min_R2 2 VPAPFSPPPSKPR 13 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 VPAPFS(1)PPPSKPR;VPAPFS(1)PPPSKPR 83.292 0.017225999999999998 38913000.0 141787.0 115327.0 185362.0 187304.0 193258.0 117857.0 147102.0 144148.0 139164.0 165662.0 True False 133907.04615833214 124172.21006524794 173436.0107268856 161792.87208257752 168979.20229155908 134090.73195067522 153942.5344770831 144567.446815014 167000.6885670428 160878.9076184327 0.8323468137658446 0.7718364818821091 1.0780531350836582 1.0056810707983703 1.0503502590428968 0.8334885780596373 0.9568845087026506 0.8986103209868525 1.0380521041523325 1.0 17.29561566520303 -5.246158535542717 24.94832091343957 0.9760133823042285 0.8020916221062412 0.510149701425995 0.0705291745767148 673.0103723743478 1098788.2892834025 0.018498733207205652 0.04854599863321681 5.673374658401384e-06 5.246158535542717 -0.17392176019798733 VPAQANGT(ph)PTTK ddPTM_A459_Selumetinib_30min_R2 1 VPAQANGTPTTK 12 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 1 VPAQANGT(0.726)PT(0.193)T(0.081)K 143.56 0.0019068 16076000.0 46611.0 30520.0 41192.0 43833.0 45348.0 33461.0 54696.0 56637.0 48624.0 39186.0 True False 44020.54721861679 32860.78586273263 38541.75156645856 37862.86978385742 39650.9788237363 38069.94902128468 57239.472378067854 56801.8042932399 58350.15866807425 38054.5983625448 1.1567734022373488 0.8635168225839384 1.012801428076383 0.9949617500397512 1.0419497387932686 1.0004033851203378 1.5041407567293037 1.4926397002562248 1.5333274079567039 1.0 15.215783173199652 -7.255040102715901 24.727080297420837 1.4235802796665327 1.005656767986505 0.5663987984426858 0.15724951710792562 273.3857234173513 1056376.8980265125 0.05724024760544703 0.0432258719905073 5.558529274880126e-08 7.255040102715901 -0.4179235116800277 VPAQCTVPSHPQSTPVHS(ph)PDR ddPTM_A459_Selumetinib_30min_R2 1 VPAQCTVPSHPQSTPVHSPDR 21 0 Q9NXL9-4;Q9NXL9 Q9NXL9-4 MCM9 DNA helicase MCM9 1 VPAQCTVPSHPQS(0.009)T(0.014)PVHS(0.976)PDR 103.59 0.00011919 2753200.0 2270.8 3674.5 5422.9 5935.1 4559.4 3032.8 1957.8 3527.7 3523.9 3656.5 True False 2144.5980267326386 3956.322334620284 5073.99651800709 5126.729141381433 3986.607410446839 3450.540670982701 2048.8415793071017 3537.965022957828 4228.778465992651 3550.927344272061 0.6039543529923393 1.1141659490730382 1.4289215255817231 1.4437719064151708 1.1226947284284952 0.9717294488012288 0.5769877501470292 0.9963495954556372 1.1908941118758793 1.0 11.793980126257033 -6.755705822803192 4.303778424992921 0.9207168163216608 1.1770073009324962 0.11772072286482271 0.25925920412475006 0.3984088202082272 17.32322081340238 0.0975575955416773 0.0916700075557232 1.7550689268738838e-07 6.755705822803192 0.25629048461083537 VPAS(ph)PLPGLER ddPTM_A459_Selumetinib_30min_R1 6 VPASPLPGLER 11 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 VPAS(1)PLPGLER;VPAS(1)PLPGLER;VPAS(1)PLPGLER;VPAS(1)PLPGLER;VPAS(1)PLPGLER;VPAS(1)PLPGLER 129.74 0.002527 594434900.0 8811.400000000001 10046.1 10993.099999999999 11837.5 10288.199999999999 8565.869999999999 10479.999999999998 8643.54 4933.2 8057.900000000001 True False 9016.688476000223 8869.897941694811 9500.29740077592 9770.302842395415 9357.63412652924 8479.705124987675 9689.48516250359 8414.285241025187 8371.28009332766 9092.209955592689 0.9916938258177802 0.9755491772645294 1.0448831964039957 1.0745795455796339 1.0291924815015172 0.9326341083634725 1.0656908727172003 0.9254389507195108 0.9207090612968545 1.0 13.150415283643527 -7.778629613504407 24.99729287157063 0.942305478567561 1.0153657025345388 0.31942658864617024 0.04491230045294779 289.6036260312454 421123.0763010297 0.024965646067392957 0.012038491232272372 1.6648318910108033e-08 7.778629613504407 0.07306022396697787 VPAS(ph)PLPGLER ddPTM_A459_Selumetinib_30min_R2 4 VPASPLPGLER 11 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 VPAS(1)PLPGLER;VPAS(1)PLPGLER;VPAS(1)PLPGLER;VPAS(1)PLPGLER 116.71 0.0058083 261837000.0 103734.0 94068.0 102863.0 116506.0 120959.0 94891.0 82063.0 97605.0 84065.0 97523.0 True False 97968.87956010379 101282.7131237071 96244.90656876638 100637.68181593974 105763.04903282001 107961.37391526625 85879.09210474954 97889.01439062241 100880.34897235219 94707.25759481579 1.0344389864950174 1.06942926757549 1.016235809303328 1.062618476891137 1.116736475311153 1.139948264336354 0.9067846993539226 1.0335957019199 1.0651807636954986 1.0 16.53118736590681 -10.497186862249587 5.22498451392645 0.9999997838964286 1.0494192361570744 0.058399854881187485 0.059557288149019866 1.559918275072774e-07 3.0637579681015834e-08 0.06001563646242476 0.014555866132785674 3.182827763763219e-11 10.497186862249587 0.04941945226064581 VPASETS(ph)PGPPPMGPPPPSSK ddPTM_A459_Selumetinib_30min_R1 1 VPASETSPGPPPMGPPPPSSK 21 0 Q9HD15 Q9HD15 SRA1 Steroid receptor RNA activator 1 1 VPAS(0.003)ET(0.161)S(0.835)PGPPPMGPPPPSSK 161.86 1.4122e-07 5701000.0 3165.9 3817.8 3683.6 3647.5 3190.8 2858.1 3417.5 3124.1 1564.6 2650.1 True False 3239.659310230961 3370.8102011529336 3183.3873525664444 3010.5325970548897 2902.192703381496 2829.3501089471674 3159.7152235549656 3041.2387194930284 2655.011926137285 2990.2661491599774 1.083401660130167 1.127260930302093 1.0645832824816341 1.0067774729351786 0.9705466198039854 0.9461867164372595 1.0566668871406613 1.0170461650536926 0.8878848215176861 1.0 11.546058182123922 -5.6988093742069355 2.448980774296677 0.9830655689865387 1.105037882885298 0.5829568607364657 0.04314316077326476 0.2064388833029419 2.5116876100994423 0.01287686514898165 0.02503255129672229 2.000739865898072e-06 5.6988093742069355 0.12197231389875929 VPASETS(ph)PGPPPMGPPPPSSK ddPTM_A459_Selumetinib_30min_R2 1 VPASETSPGPPPMGPPPPSSK 21 0 Q9HD15 Q9HD15 SRA1 Steroid receptor RNA activator 1 1 VPAS(0.014)ET(0.264)S(0.722)PGPPPMGPPPPSSK 94.958 0.00043055 10208000.0 29492.0 26380.0 31262.0 30905.0 33177.0 22230.0 25509.0 25122.0 23102.0 31658.0 True False 27852.952705830074 28403.261174930773 29250.636955492027 26695.685685901353 29009.008653856814 25291.980716151873 26695.21904512457 25195.100860829025 27723.04552381233 30743.951282637743 0.9059652889041518 0.9238650202705452 0.9514273779119262 0.8683231846316841 0.9435680009758305 0.8226652613268743 0.8683080063362043 0.8195140770684749 0.9017398339252694 1.0 14.908014974946727 -6.744096113880165 24.99839883979811 0.8702814592292288 0.9179478962950104 0.08546851100355624 0.05204184354082442 430.86398137645267 621041.7645523746 0.01613799339754141 0.016100908334622993 1.8026187584554182e-07 6.744096113880165 0.04766643706578155 VPCNVEGIS(ph)PELEK ddPTM_A459_Selumetinib_30min_R2 2 VPCNVEGISPELEK 14 0 Q86VQ1;H7C2L5;H7C0B2 Q86VQ1 GLCCI1 Glucocorticoid-induced transcript 1 protein 1 VPCNVEGIS(1)PELEK;VPCNVEGIS(1)PELEK 130.64 0.00095474 9177100.0 37726.0 34038.0 37788.0 30819.0 40387.0 28146.0 32880.0 32841.0 27844.0 31376.0 True False 35629.3399491437 36648.60515057973 35356.76122046356 26621.399034259637 35313.223995639 32022.85601605087 34408.985150483975 32936.561872879785 33413.57802636268 30470.093355361765 1.169321653649416 1.202772985404416 1.160375874406105 0.8736894476752602 1.158947023358069 1.0509602199960397 1.129270749163264 1.0809471926702843 1.0966024172184874 1.0 14.895106299761283 -5.54689747892767 24.999691614233306 1.062516980285946 1.1849292966939111 0.36001457155354455 0.07450910881220442 233.29058112495215 242817.2692173948 0.019639071883516785 0.03401786769554487 2.8385890365989966e-06 5.54689747892767 0.12241231640796513 VPDEEENEES(ph)DNEK ddPTM_A459_Selumetinib_30min_R1 2 VPDEEENEESDNEK 14 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 VPDEEENEES(1)DNEK;VPDEEENEES(1)DNEK 202.32 1.8034999999999998e-21 6271900.0 1664.81 2760.6000000000004 1898.1200000000001 1642.94 1773.33 1508.57 1997.3000000000002 1982.7400000000002 1005.89 2620.1 True False 1703.5968338436478 2437.387668631878 1640.3657296268375 1356.031370803389 1612.932614606841 1493.3951554719672 1846.6420529645445 1930.151294352808 1706.9218627011605 2956.4153569352293 0.5762373104466901 0.8244402001613867 0.5548495497355703 0.4586741736482929 0.5455703681227286 0.50513712559662 0.6246219931961345 0.6528687824006235 0.5773619930288288 1.0 11.529633257561072 -10.230380566085012 0.7563648269979232 1.0433096714552044 0.5882242302248499 0.6304708657855904 0.09389874721556828 18.824193921164046 6.60037749457653 2.2730511372917053 0.03500680398178236 5.883278860390345e-11 10.230380566085012 -0.45508544123035444 VPDEEENEES(ph)DNEK ddPTM_A459_Selumetinib_30min_R2 2 VPDEEENEESDNEK 14 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 VPDEEENEES(1)DNEK;VPDEEENEES(1)DNEK 244.18 5.4237e-20 30924000.0 57031.0 36159.0 42378.0 43894.0 43651.0 50083.0 62575.0 73512.0 50240.0 37607.0 True False 53861.445333181735 38932.279030489815 39651.4456176777 37915.56147862655 38167.17113510874 56981.47864179197 65484.86149001022 73725.90774943336 60289.40382288683 36521.18819527951 1.4747999173844928 1.0660189592495775 1.085710722380133 1.0381798444204855 1.0450692603709422 1.5602306895687754 1.7930649227473483 2.018716021921836 1.6508061977753354 1.0 15.156446082865882 -6.8695840035057865 4.464773431529121 1.6972090287709276 1.1295802622846556 0.40485258383561895 0.2729198183526385 0.1815914641895257 6.27179525766678 0.09538220308410181 0.08419886114865129 1.3502556291022778e-07 6.8695840035057865 -0.567628766486272 VPDEEENEES(ph)DNEKETEK ddPTM_A459_Selumetinib_30min_R1 3 VPDEEENEESDNEKETEK 18 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 VPDEEENEES(0.999)DNEKET(0.001)EK;VPDEEENEES(1)DNEKETEK;VPDEEENEES(1)DNEKETEK 113.33 0.00064512 587150000.0 5774.83 11912.1 5765.84 5466.43 5137.85 7170.67 7856.04 7853.33 4367.34 8864.61 True False 5909.372303136883 10517.425794214949 4982.870597492049 4511.820618099733 4673.132374661094 7098.539570247433 7263.45257786591 7645.03417718901 7411.057002106875 10002.469042113513 0.5907913614385192 1.0514829638495562 0.4981640609446138 0.45107069055685767 0.46719788434093124 0.7096787343565243 0.7261659643518525 0.7643147051993895 0.7409227632601526 1.0 13.288068543063414 -8.625187253990774 0.7518921526435716 0.9949635671522398 0.6325779564869152 0.3049875670282952 0.16441704404013938 1.1329702198010327 1.4037794931968408 0.17454164517838422 0.06509616932452457 2.370351465010895e-09 8.625187253990774 -0.3623856106653246 VPDEEENEES(ph)DNEKETEK ddPTM_A459_Selumetinib_30min_R2 4 VPDEEENEESDNEKETEK 18 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 VPDEEENEES(1)DNEKETEK;VPDEEENEES(1)DNEKETEK;VPDEEENEES(1)DNEKETEK;VPDEEENEES(1)DNEKETEK 113.71 0.00063016 1171670000.0 306193.0 223063.0 253025.0 224411.0 212501.0 231877.0 362151.0 364143.0 248521.0 209385.0 True False 289176.0188476956 240171.21483940774 236745.64697279045 193845.83466943237 185804.72459695663 263815.95198016893 378991.73908859235 365202.59584288107 298232.1442569198 203339.51100243587 1.4221339346303015 1.1811340238569308 1.1642874806065329 0.9533112070241491 0.913765965507465 1.297416083473362 1.8638371717341855 1.7960237734539757 1.4666709031937584 1.0 17.633531047656057 -7.024944289610578 9.211205065236921 1.5959732023276147 1.1205501531686677 0.34789377598544846 0.2551373782650489 0.3422809061462661 120.36690772496786 0.09510140634156922 0.07576581423188948 9.441819862118291e-08 7.024944289610578 -0.47542304915894706 VPDS(ph)PENELK ddPTM_A459_Selumetinib_30min_R2 3 VPDSPENELK 10 0 A0A0U1RR46;A0A0X1KG69;A0A087WUZ6;A0A2R8Y549;Q8NI35-4;Q8NI35-3;Q8NI35-2;Q8NI35 A0A0U1RR46 INADL InaD-like protein 1 VPDS(1)PENELK;VPDS(1)PENELK;VPDS(1)PENELK 136.27 0.0018735 22628100.0 178925.0 169169.0 154278.0 153859.0 145065.0 126824.0 165546.0 145321.0 115488.0 131889.0 True False 168981.06479352523 182143.7183359309 144351.9214451856 132903.13877842086 126840.63780244568 144292.85480635383 173244.21702317562 145743.86005081344 138588.82700433052 128081.02188122441 1.3193294549931789 1.4220976352362442 1.1270359911638586 1.0376489570927083 0.9903156294308066 1.1265748249585597 1.3526142630547808 1.137903632483262 1.0820402973740364 1.0 16.96669719784314 -5.271140935062964 22.802744882048376 1.1145520355112184 1.3707135431395738 0.5302321317815122 0.0991604371660904 153.455295617061 360687.9059166416 0.02817487022852632 0.06008282073505718 5.356228116837042e-06 5.271140935062964 0.25616150762835543 VPEASSEPFDTSS(ph)PQAGR ddPTM_A459_Selumetinib_30min_R1 2 VPEASSEPFDTSSPQAGR 18 0 H0Y6F5;Q9H4I2 H0Y6F5 ZHX3 Zinc fingers and homeoboxes protein 3 1 VPEASSEPFDT(0.002)S(0.232)S(0.767)PQAGR;VPEASSEPFDTS(0.028)S(0.971)PQAGR 223.86 1.3299e-51 12707000.0 2322.08 2619.16 2365.79 2823.2 2728.7799999999997 2536.7799999999997 2742.77 2411.0 1472.03 1938.25 True False 2376.179946018859 2312.5075295855495 2044.5287123542648 2330.1811180275163 2481.9623308052396 2511.262296411951 2535.880650683205 2347.052447968277 2497.927397182582 2187.0432676537957 1.0864805379767197 1.0573670689498287 0.9348368834730842 1.0654481109225036 1.1348482983913828 1.1482453655825333 1.1595018206492245 1.0731623295620187 1.1421481385973193 1.0 11.094766047074655 -6.003697991626014 24.982697278203702 1.1161329053477225 1.0244754605506274 0.3012863398058683 0.05677500799880763 172.08602576527542 1162589.6060369834 0.01590679082108612 0.023033239129183623 9.915212090366894e-07 6.003697991626014 -0.09165744479709503 VPEEAAQDRPMS(ph)PGDCPPETTETPK ddPTM_A459_Selumetinib_30min_R1 1 VPEEAAQDRPMSPGDCPPETTETPK 25 1 P13994 P13994 CCDC130 Coiled-coil domain-containing protein 130 1 VPEEAAQDRPMS(0.999)PGDCPPET(0.001)TETPK 69.071 0.00078791 11400000.0 1288.0 1424.9 1428.7 1801.7 1494.2 1411.5 1422.0 1345.9 938.15 1149.9 True False 1318.007893988275 1258.0720455819612 1234.6903872873486 1487.0669170976832 1359.049873822436 1397.3015915394587 1314.7373951412328 1310.2023599006652 1591.9720302350086 1297.5008659745135 1.015805020675928 0.9696117194010976 0.9515911855365199 1.146100905282088 1.0474365832516765 1.076917656228297 1.0132844066765023 1.0097891988045895 1.2269525762815785 1.0 10.34151978612518 -5.741411816604119 24.99075502720124 1.0712030084939645 0.97806352626709 0.2977661531040343 0.06697601957028682 308.42465823372385 384854.8101925695 0.017699890342377487 0.030607179447467096 1.8137949291309433e-06 5.741411816604119 -0.09313948222687451 VPEEAAQDRPMS(ph)PGDCPPETTETPK ddPTM_A459_Selumetinib_30min_R2 1 VPEEAAQDRPMSPGDCPPETTETPK 25 1 P13994 P13994 CCDC130 Coiled-coil domain-containing protein 130 1 VPEEAAQDRPMS(0.999)PGDCPPETTETPK 50.18899999999999 0.020274 22697000.0 27607.0 28834.0 26755.0 28744.0 28173.0 20656.0 13058.0 23598.0 15436.0 19719.0 True False 26072.713459577215 31045.47508407709 25033.61242864144 24829.017613834287 24633.6558701844 23501.176503501276 13665.222873936133 23666.666273140803 18523.63131787582 19149.661233885072 1.3615234829032847 1.6212023129235589 1.3072613725586328 1.2965773812175678 1.2863755431138109 1.2272371932050816 0.7136012855285242 1.2358791095094126 0.9673085644511821 1.0 14.225031250001667 -6.515458606354705 0.9650128124041524 0.9960090504376877 1.4588508490517251 0.5954576883586004 0.15112037044576995 0.3826589215979282 0.7721509909348998 0.07874377261827377 0.09359285400778193 3.051696879804991e-07 6.515458606354705 0.4628417986140374 VPEPEGQTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 1 VPEPEGQTSPK 11 0 Q504Q3-2;Q504Q3-3;Q504Q3 Q504Q3-2 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 1 VPEPEGQT(0.018)S(0.982)PK 132.14 0.002068 17353000.0 3110.0 3635.5 3680.4 3582.8 2526.1 2961.3 3157.4 3160.6 1927.5 3068.3 True False 3182.456948993427 3209.853969901903 3180.6218949901026 2957.1312374854715 2297.6147010191794 2931.5120106452728 2919.2347759626778 3076.7706209243206 3270.8267209699725 3462.146192772937 0.9192150682824002 0.9271283738977626 0.9186850346266421 0.8541324002026085 0.6636388451231029 0.8467325893876644 0.8431864552850019 0.8886888217912146 0.9447396322540237 1.0 11.75745092997192 -9.91054571516288 10.857253930566406 0.9999999997445576 0.8635480642546811 0.21264662225322095 0.07625955084801482 0.0 0.0 0.08090150041112976 0.01962149596859051 1.2287238405487208e-10 9.91054571516288 -0.13645193548987644 VPFAPGPS(ph)PPPLLGNMDQER ddPTM_A459_Selumetinib_30min_R1 2 VPFAPGPSPPPLLGNMDQER 20 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 VPFAPGPS(1)PPPLLGNMDQER;VPFAPGPS(1)PPPLLGNMDQER 107.69 0.0011975 8643300.0 1186.44 1106.81 616.88 666.62 1118.88 825.6400000000001 1358.08 1267.1399999999999 702.38 1400.1399999999999 True False 1214.0817435896333 977.2241706579908 533.1110842792889 550.2073310071918 1017.6775015543083 817.3348112211401 1255.6389322035193 1233.5313309491996 1191.8875601944956 1579.8616075185275 0.7684734775576825 0.6185504894905997 0.3374416352307219 0.3482629923967814 0.6441561062761465 0.5173458278443258 0.7947777996679966 0.7807844212928844 0.7544252955590086 1.0 10.625582471614292 -7.735597171219791 0.8207113655790738 0.9351643144601757 0.5162568674073102 0.5338229033676356 0.13525974668945706 0.5212996851739538 0.6536082640817427 0.1314818355870083 0.05921107366457385 1.8382426102509058e-08 7.735597171219791 -0.4189074470528654 VPFAPGPS(ph)PPPLLGNMDQER ddPTM_A459_Selumetinib_30min_R2 2 VPFAPGPSPPPLLGNMDQER 20 0 O75420 O75420 GIGYF1 PERQ amino acid-rich with GYF domain-containing protein 1 1 VPFAPGPS(1)PPPLLGNMDQER;VPFAPGPS(1)PPPLLGNMDQER 119.62 0.00025381 10416100.0 30955.3 18616.1 27072.7 34627.4 35162.2 23828.9 32040.8 33749.5 26765.5 19369.3 True False 29234.928349884096 20043.89500980396 25330.87195652704 29911.088384403174 30744.810081943637 27111.114677782793 33530.76068764074 33847.705457469514 32119.347890554876 18810.05798151479 1.554217875277904 1.0655945361519725 1.3466663410299133 1.5901646030967953 1.63448778904124 1.441309468818528 1.7825974125434607 1.799447162296505 1.7075624074162623 1.0 14.199216675487374 -5.726797763031592 4.377873705236954 1.6067196603641065 1.2878144464328982 0.1575607529796772 0.2440198131764316 0.28006579148792693 11.900695199056925 0.06510073746880622 0.11190307342088987 1.8758678360134133e-06 5.726797763031592 -0.3189052139312083 VPGEDGTLPPT(ph)QGSPLR ddPTM_A459_Selumetinib_30min_R1 1 VPGEDGTLPPTQGSPLR 17 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 VPGEDGTLPPT(0.572)QGS(0.427)PLR 94.61 0.023796 0.0 533.09 658.82 554.31 677.96 683.43 874.54 612.42 722.0 399.74 566.35 True False 545.5099597874296 581.6850481228915 479.03774660688043 559.5670128853557 621.6138771693668 865.7429216187875 566.2246663378291 702.8502146134778 678.3295841455447 639.0465392161628 0.8536310367262724 0.9102389457211844 0.7496132397406535 0.8756279528118647 0.9727208255158091 1.354741585300946 0.8860460570404544 1.0998419856487678 1.061471336622158 1.0 9.319777190511106 -6.397879725643501 3.892946291628824 1.0814607080143255 0.8453279779904893 0.461927857736959 0.11722518056913044 0.21103265307264185 5.572208396190541 0.03688880632589752 0.041919502227387 4.0005552657479123e-07 6.397879725643501 -0.23613273002383617 VPGEDGTLPPTQGS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 4 VPGEDGTLPPTQGSPLR 17 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 VPGEDGTLPPT(0.101)QGS(0.899)PLR;VPGEDGTLPPT(0.065)QGS(0.935)PLR;VPGEDGTLPPTQGS(1)PLR;VPGEDGTLPPT(0.002)QGS(0.998)PLR 182.28 7.015e-08 56520400.0 4086.7200000000003 4284.17 4669.63 4940.36 5031.15 4398.8099999999995 4484.43 3823.96 2224.34 3680.75 True False 4181.932624627144 3782.577384743401 4035.5198944415374 4077.618868042797 4576.083370821678 4354.561965199918 4146.165834664694 3722.536158827364 3774.542520634164 4153.210116041127 1.0069157369320374 0.9107599372672684 0.9716628298806677 0.98179932007139 1.1018184110520364 1.048481016739582 0.9983038947754592 0.8963033544702321 0.9088253219011438 1.0 12.020011145999192 -7.7209789403305225 10.987911982059748 0.9269580725627519 1.0028806997074362 0.24960095588819553 0.05330458851247918 0.776888110803627 208.14882886998888 0.02768676362782819 0.015918529270212152 1.9011704686399856e-08 7.7209789403305225 0.07592262714468434 VPGEDGTLPPTQGS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 5 VPGEDGTLPPTQGSPLR 17 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 VPGEDGTLPPT(0.233)QGS(0.767)PLR;VPGEDGTLPPT(0.081)QGS(0.919)PLR;VPGEDGTLPPT(0.031)QGS(0.969)PLR;VPGEDGTLPPT(0.119)QGS(0.881)PLR;VPGEDGTLPPT(0.095)QGS(0.905)PLR 158.92 3.3702e-05 38377100.0 73082.79999999999 64909.3 70426.1 90201.09999999999 83520.2 61870.7 68451.5 69737.4 68754.0 73079.9 True False 69021.15054962841 69887.63459370474 65894.96140013983 77915.55457442327 73027.64579593841 70392.82731870527 71634.63038407403 69940.32428835191 82506.72114726814 70969.89340261671 0.9725412740592273 0.9847504518180372 0.9284917623634226 1.097867713178085 1.0289947228981724 0.9918688607768127 1.009366464420148 0.9854928750079419 1.1625594627739155 1.0 16.11491951895149 -5.747534694543345 24.99964104071052 1.035173892389756 0.9642100972155899 0.306655677023137 0.05311277328883095 317.59383257117327 571006.8824276499 0.0142582837461295 0.024534029843236025 1.7884026530307607e-06 5.747534694543345 -0.07096379517416607 VPGEQGS(ph)DEEHCK ddPTM_A459_Selumetinib_30min_R2 3 VPGEQGSDEEHCK 13 0 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 1 VPGEQGS(1)DEEHCK;VPGEQGS(1)DEEHCK;VPGEQGS(1)DEEHCK 170.42 0.0002282 27396900.0 46285.9 44513.3 47460.2 49587.4 52752.9 49080.1 51428.399999999994 49091.3 51010.5 50073.3 True False 43713.514975138394 47927.32697718144 44406.66240275867 42833.510576963745 46125.609085090386 55840.43827021169 53819.92250344131 49234.14755549776 61214.025352455574 48627.553722942204 0.8989453844254273 0.9856002062174392 0.9131995957634994 0.8808485580214399 0.9485488278496021 1.1483291672117673 1.106778325927783 1.0124742822970625 1.2588341519547825 1.0 15.56948639616102 -6.692393385972758 5.974420217377728 1.1059093106290476 0.9235504155923651 0.6103034598473251 0.07199113949847787 0.1364630444813529 8.725517741443225 0.02294757406656742 0.022752476631474883 2.030516925955666e-07 6.692393385972758 -0.18235889503668257 VPGGS(ph)PLGVSLVYSDK ddPTM_A459_Selumetinib_30min_R2 1 VPGGSPLGVSLVYSDK 16 0 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 VPGGS(0.998)PLGVS(0.002)LVYSDK 138.05 0.00040569 2967400.0 6600.3 6408.0 7494.3 10369.0 11017.0 7865.8 8010.2 10085.0 4690.9 6646.2 True False 6233.481749094345 6899.4729950324645 7012.124897176886 8956.724312477303 9632.94596677037 8949.242551376856 8382.690171910184 10114.345680338374 5629.2110746970475 6454.3069370985895 0.9657863826191829 1.0689719380054756 1.0864256945810906 1.3877127939167435 1.4924834007198111 1.3865536049947784 1.2987746405005125 1.5670692111344002 0.8721635226767743 1.0 12.65604647204701 -5.6627065853388165 4.9798874565435804 1.3228609083754546 1.0322209921682766 0.22542889864482185 0.2027846435547501 0.26112845722607264 10.536821394465903 0.05340482085149701 0.094059432276323 2.174169578319712e-06 5.6627065853388165 -0.290639916207178 VPGGS(ph)PLGVSLVYSDKK ddPTM_A459_Selumetinib_30min_R1 1 VPGGSPLGVSLVYSDKK 17 1 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 VPGGS(1)PLGVSLVYSDKK 98.292 0.0026943 23441000.0 1559.4 1606.3 1739.8 1851.9 2050.6 1315.4 1654.8 1526.6 844.24 1466.3 True False 1595.7309859358036 1418.2336492513903 1503.5447160373271 1528.5004294683893 1865.1235920628346 1302.1682702876415 1529.977103712876 1486.1096089043424 1432.613619150034 1654.5138879715 0.9644711945526389 0.857190537693341 0.9087531552126968 0.9238365664868439 1.1272940079998666 0.7870397944402581 0.9247290789373118 0.8982152520498767 0.8658818941111914 1.0 10.692191686329776 -10.12401505214809 15.101330384733176 0.9996175392292898 0.9176262599197722 0.0803940821285003 0.08371527745978766 0.0 0.0 0.08002738304733889 0.01940949136740838 7.515968440831376e-11 10.12401505214809 -0.08199127930951755 VPGGS(ph)PLGVSLVYSDKK ddPTM_A459_Selumetinib_30min_R2 1 VPGGSPLGVSLVYSDKK 17 1 I3L2J0;A0A0A0MQR4;Q96RK0 I3L2J0 CIC Protein capicua homolog 1 VPGGS(1)PLGVSLVYSDKK 92.474 0.0040378 9263900.0 20626.0 19364.0 22644.0 28157.0 25831.0 16420.0 19253.0 17449.0 15301.0 20295.0 True False 19479.689492420017 20849.15653492644 21187.10969292308 24321.96802646575 22585.87884793005 18681.705954080695 20148.302649095745 17499.773701162554 18361.62754566064 19709.030617257355 0.9883636527188443 1.0578478941866771 1.0749950164657773 1.2340519682976838 1.1459659932819684 0.9478754342044033 1.0222878557737771 0.8879063633824608 0.9316352438756212 1.0 14.266569199154189 -6.769782542175681 24.900045910214505 0.9549567744194287 1.1039204715672164 0.5197928719848784 0.06831321347302069 152.9530981438359 456483.1278947142 0.026033649592536377 0.023338630376520186 1.6990942017014775e-07 6.769782542175681 0.14896369714778768 VPGPAEGPAEPAAEAS(ph)DEAERR ddPTM_A459_Selumetinib_30min_R1 2 VPGPAEGPAEPAAEASDEAERR 22 1 Q24JP5;Q24JP5-2;H0YFQ2;Q24JP5-4 Q24JP5 TMEM132A Transmembrane protein 132A 1 VPGPAEGPAEPAAEAS(1)DEAERR;VPGPAEGPAEPAAEAS(1)DEAERR 124.66 1.6497e-05 14500500.0 2426.14 2340.6 2149.99 2284.18 2786.4 2396.18 2394.2 2206.59 1027.77 1794.01 True False 2482.6643415533467 2066.5614638845805 1858.0331670497133 1885.2908423689764 2534.370611978876 2372.0766047573647 2213.603566418522 2148.0640651855333 1744.0506246491866 2024.288658637218 1.2264379049698941 1.020882795083099 0.9178696719570466 0.9313349824516544 1.2519808383874722 1.1718074863662393 1.0935216956206006 1.0611451365990672 0.8615622170324799 1.0 10.983199314166095 -8.143521560735158 6.10727519226767 0.9325023776275778 1.0816803916330864 0.23886626235819375 0.11002473943235544 0.36549514972054614 16.5012394960047 0.0826618902096398 0.0304611251817562 7.1858548301150105e-09 8.143521560735158 0.14917801400550856 VPGS(ph)SGHLHK ddPTM_A459_Selumetinib_30min_R2 1 VPGSSGHLHK 10 0 Q9UEW8-2;Q9UEW8 Q9UEW8-2 STK39 STE20/SPS1-related proline-alanine-rich protein kinase 1 VPGS(0.5)S(0.5)GHLHK 79.82 0.035593 0.0 25052.0 18223.0 25858.0 26132.0 24056.0 24270.0 24114.0 24857.0 23754.0 25531.0 True False 23659.710131101845 19620.64550381968 24194.32443206169 22572.776519785595 21033.870216631392 27612.97219887569 25235.348780984514 24929.329754702136 28505.46374221445 24793.853692495573 0.9542570680838935 0.7913511851430468 0.9758194402584806 0.9104182350893585 0.8483501789396206 1.1137023127321828 1.0178066344169228 1.0054640986385899 1.1496987961513334 1.0 14.597694905550913 -6.75895739334567 24.999999997749764 1.0552053967274875 0.895454279171532 0.6048900844970557 0.06516741953373095 44.93241160946785 452586.1960398024 0.021264205930326383 0.02031739012639884 1.741977762516168e-07 6.75895739334567 -0.1597511175559555 VPKPEPIPEPKEPS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 VPKPEPIPEPKEPSPEK 17 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 VPKPEPIPEPKEPS(1)PEK;VPKPEPIPEPKEPS(1)PEK 111.4 0.0022953 484980000.0 12268.0 17533.7 19156.0 22008.5 11123.2 15159.4 12983.400000000001 12983.2 10781.0 13910.6 True False 12553.820530627445 15480.846252804015 16554.720416376033 18165.128625711455 10117.108523960467 15006.910199633918 12004.051685004692 12638.84336062286 18294.569586914273 15696.16101071837 0.7998019720908107 0.9862823299425048 1.0546986874734134 1.1572975464068642 0.6445594255214279 0.9560879370048647 0.76477628362805 0.8052187634920556 1.1655442101047218 1.0 13.938124125414799 -4.748055604507661 24.35355803749666 0.9370635652115157 0.7998015041586178 0.06862396667149018 0.15934694307005923 1609.1658644111299 2927850.5360946795 0.040281630256617476 0.7415867799331805 1.7862588581466696e-05 4.748055604507661 -0.13726206105289784 VPKPEPIPEPKEPS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 2 VPKPEPIPEPKEPSPEK 17 2 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 VPKPEPIPEPKEPS(1)PEK;VPKPEPIPEPKEPS(1)PEK 74.14699999999998 0.010405 257649000.0 264023.0 369271.0 248067.0 240965.0 170467.0 120758.0 134277.0 114588.0 65464.0 222397.0 True False 249349.65862781034 397592.89830659004 232106.6392949274 208145.15131218947 149051.41146568433 137391.31836801945 140521.14656482774 114921.4321089353 78558.62921698784 215975.820753199 1.1545258064454746 1.8409139361990408 1.0746880761257136 0.9637428420750959 0.6901300846820678 0.6361421287294006 0.650633696284941 0.5321032313161523 0.36373807467438113 1.0 17.720510281121705 -5.795038848932862 1.4948547801561527 0.6139463439383135 1.5004821849543388 0.6723621107588482 0.22842743888098757 0.21464183311689888 0.9711228236723711 0.07186102023239065 0.157956179425852 1.6031019820365566e-06 5.795038848932862 0.8865358410160253 VPKPEPIPEPKEPS(ph)PEKNSK ddPTM_A459_Selumetinib_30min_R1 1 VPKPEPIPEPKEPSPEKNSK 20 3 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 VPKPEPIPEPKEPS(0.944)PEKNS(0.056)K 64.454 0.012696 23362000.0 2341.7 1734.9 8085.2 8880.7 3033.3 3530.7 2242.0 2706.7 2364.7 1848.4 True False 2396.2570538449845 1531.7771014668708 6987.274248824572 7329.852456385298 2758.938550572612 3495.1843636191047 2072.884134955443 2634.90952339931 4012.723189145367 2085.6601449406808 1.1489201918432101 0.7344327431209733 3.3501499588866626 3.5144040481215457 1.3228130945806993 1.6758168257170742 0.993874356751636 1.263345578996165 1.9239583202849642 1.0 11.02628837677004 VPLAPITDPQQLQLS(ph)PLK ddPTM_A459_Selumetinib_30min_R1 2 VPLAPITDPQQLQLSPLK 18 0 P31350-2;P31350;A0A286YFD6 P31350-2 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 VPLAPIT(0.001)DPQQLQLS(0.999)PLK;VPLAPIT(0.001)DPQQLQLS(0.999)PLK 99.747 0.0029542 2049230000.0 4311.3 5942.1 5476.8 6060.200000000001 4817.6 5570.3 4986.3 5096.7 3077.66 4542.8 True False 4411.744901670535 5246.396169592657 4733.080641908973 5001.89983404306 4381.848930616362 5514.267839427734 4610.1793765068405 4961.518959585198 5222.564236607235 5125.912630619198 0.8606750094251229 1.0235047976147233 0.9233635028494873 0.9758066893619375 0.8548426878058288 1.0757631346443028 0.8993870377283316 0.9679288971778394 1.0188554922709172 1.0 12.323593173270778 -8.110109446119198 4.7674030539026395 1.0079557676677844 0.9487820627907619 0.13133762275686556 0.06507501437436812 0.4741828640670298 16.37753145430007 0.04342296421089317 0.015587161360703532 7.760515200141857e-09 8.110109446119198 -0.05917370487702245 VPLAPITDPQQLQLS(ph)PLK ddPTM_A459_Selumetinib_30min_R2 2 VPLAPITDPQQLQLSPLK 18 0 P31350-2;P31350;A0A286YFD6 P31350-2 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 VPLAPITDPQQLQLS(1)PLK;VPLAPITDPQQLQLS(1)PLK 181.51 1.0957e-09 2070100000.0 4417200.0 4289200.0 3719250.0 4490300.0 4299500.0 2860070.0 4330400.0 3797100.0 3159160.0 4375100.0 True False 4171709.707452622 4618167.848048267 3479957.504213215 3878713.3938004426 3759358.3719823183 3254018.681369524 4531772.180524813 3808148.9323562565 3791080.2743055574 4248779.49512503 0.9818607231180538 1.0869398737559965 0.8190487428698178 0.9129006102224899 0.8848090083977612 0.7658713955626842 1.0666056418612646 0.8962924380344179 0.8922751295178701 1.0 22.018617041348058 -5.2534998249777995 24.971315580677743 0.9014245705993824 1.0344003006990556 0.28223653997712017 0.08258389303168456 717.2542281565126 2255879.158863154 0.020588480152993124 0.05241541839998422 5.578278269477275e-06 5.2534998249777995 0.13297573009967323 VPLS(ph)PLSLLAGPADAR ddPTM_A459_Selumetinib_30min_R2 1 VPLSPLSLLAGPADAR 16 0 Q53ET0;H0YDQ8;Q5T4K5 Q53ET0 CRTC2 CREB-regulated transcription coactivator 2 1 VPLS(0.988)PLS(0.012)LLAGPADAR 110.6 0.0027679 104170000.0 128770.0 114870.0 145270.0 163200.0 140220.0 139730.0 102300.0 115970.0 122280.0 107660.0 True False 121613.47890715231 123680.15963473436 135923.4863580166 140971.87846429687 122604.31001729523 158976.53915735046 107057.15270360444 116307.45350013308 146739.41678866633 104551.57606572693 1.1631912543403393 1.1829583473421974 1.3000615722193185 1.3483477128615844 1.1726682143961116 1.5205561230125213 1.0239649819941725 1.1124409394557166 1.4035122406611813 1.0 16.673855284475927 -10.704374256922208 4.38453288332199 0.999951776138213 1.2454147661834412 0.21860528660637335 0.14034053559330031 8.556139691184184e-05 1.5972821124023023e-05 0.13397530588981066 0.03248542404643888 1.9752667037633775e-11 10.704374256922208 0.2454629900452282 VPLSNENSQVPQS(ph)PEDWR ddPTM_A459_Selumetinib_30min_R1 1 VPLSNENSQVPQSPEDWR 18 0 Q8IZT6-2;Q8IZT6 Q8IZT6-2 ASPM Abnormal spindle-like microcephaly-associated protein 1 VPLSNENSQVPQS(1)PEDWR 162.81 6.6802999999999985e-06 5872900.0 423.06 441.47 503.03 388.71 412.55 276.45 414.74 345.0 187.89 431.95 True False 432.9164748685401 389.7824871661649 434.72128894600314 320.82909549039255 375.2349253416183 273.6691639965167 383.4558278909103 335.84947928206367 318.8356070573531 487.3949900493007 0.8882251227587505 0.79972608484699 0.8919281031223371 0.6582527560612395 0.7698785030672202 0.5614935926379437 0.7867455261534864 0.689070438020079 0.6541626679935763 1.0 8.928947611397783 -5.756647811782978 24.998933189141834 0.7152499355672826 0.8539364181792085 0.20646736885117933 0.1122689104923126 162.75084921900697 849103.1254373721 0.02846196339871159 0.047334941854267745 1.7512662906707082e-06 5.756647811782978 0.13868648261192595 VPLSNENSQVPQS(ph)PEDWR ddPTM_A459_Selumetinib_30min_R2 1 VPLSNENSQVPQSPEDWR 18 0 Q8IZT6-2;Q8IZT6 Q8IZT6-2 ASPM Abnormal spindle-like microcephaly-associated protein 1 VPLS(0.026)NENS(0.026)QVPQS(0.948)PEDWR 99.413 0.0030354 2579900.0 7024.4 4950.9 6538.8 5480.9 4637.8 4472.5 6694.6 5376.2 4313.4 8065.9 True False 6634.011968901158 5330.61811034741 6118.1007269071415 4734.391964920131 4055.158101541944 5088.5462776873255 7005.912165098235 5391.843851922176 5176.200526465764 7833.0165092749985 0.8469293995545508 0.6805319641590794 0.7810657260408883 0.6044149095452797 0.5177006963716048 0.6496279270779051 0.8944079406449102 0.688348332412902 0.6608182837782449 1.0 12.935352283736675 -10.630500283481075 3.679273423549578 1.0001533035356125 0.6996362660640228 0.4131191544527768 0.10626840995182142 92054960.69769904 167267353.33383176 175753.9835670643 0.028030027440066406 2.3415299467601945e-11 10.630500283481075 -0.30051703747158964 VPLSNENSQVPQS(ph)PEDWRK ddPTM_A459_Selumetinib_30min_R2 2 VPLSNENSQVPQSPEDWRK 19 1 Q8IZT6-2;Q8IZT6 Q8IZT6-2 ASPM Abnormal spindle-like microcephaly-associated protein 1 VPLSNENSQVPQS(1)PEDWRK;VPLSNENSQVPQS(1)PEDWRK 134.47 0.00010572 19346500.0 14896.4 14199.8 16842.8 17752.5 19495.0 16556.4 17165.3 15535.9 15989.7 19419.3 True False 14068.517723013949 15288.879000446614 15759.152585054091 15334.578875229376 17045.863812488733 18836.89381596478 17963.52046239667 15581.1068968933 19188.086789546433 18858.614351599208 0.7459995448616266 0.8107106235591545 0.8356474283444753 0.8131339126688809 0.9038767904516403 0.9988482432892751 0.952536603564056 0.8262063482713948 1.0174706599225454 1.0 14.202936056542532 -6.338395388055816 2.9189413612121142 0.9482495269419824 0.8019476638165325 0.6491756002985221 0.054367374567692965 0.1868845962965361 3.1163181612952124 0.01799482669418284 0.021357434549274523 4.587801424883263e-07 6.338395388055816 -0.1463018631254499 VPLT(ph)PTR ddPTM_A459_Selumetinib_30min_R2 2 VPLTPTR 7 0 Q68CZ2;Q68CZ2-2;E9PCX8 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 VPLT(1)PTR;VPLT(0.997)PT(0.003)R 109.44 0.037049 153162000.0 470530.0 397120.0 412260.0 499950.0 512720.0 420060.0 435653.0 419960.0 374400.0 435600.0 True False 444379.82628083025 427577.82705794164 385735.64043474954 431855.94753814535 448307.5298250428 477919.45207497844 455911.7277300429 421182.01407187915 449290.46161004907 423023.09617527935 1.0504859670751918 1.0107670974087313 0.9118547992351704 1.020880305219094 1.059770811282812 1.129771533507364 1.0777466569842706 0.9956477976733513 1.0620944002165922 1.0 18.690376908060763 -6.002044134503124 24.98055656972977 1.057223219412812 0.988568818514057 0.2589213381399471 0.047950239856116364 107.17134228395815 1309743.195219791 0.014302058646559873 0.02083522526683888 9.953042659596461e-07 6.002044134503124 -0.06865440089875496 VPPAPVPCPPPS(ph)PGPSAVPSSPK ddPTM_A459_Selumetinib_30min_R2 1 VPPAPVPCPPPSPGPSAVPSSPK 23 0 O95817 O95817 BAG3 BAG family molecular chaperone regulator 3 1 VPPAPVPCPPPS(0.999)PGPSAVPSSPK 108.13 1.2127e-05 10763000.0 83172.0 70128.0 82675.0 95060.0 87140.0 72091.0 74070.0 94211.0 74647.0 118460.0 True False 78549.63320389605 75506.59210293958 77355.78050973399 82112.66401235359 76192.69415851597 82020.88087305921 77514.40176692055 94485.13841252924 89578.48581144592 115039.75200395669 0.6828042640529546 0.6563521807691536 0.6724265235470379 0.713776434510476 0.6623162240118128 0.7129785960442455 0.6738053622043145 0.8213259918126345 0.7786741908863377 1.0 16.81177294525149 -8.757507280267593 0.5801044996287861 1.0068385297578308 0.6707907869239084 0.9035029244865899 0.031421209421406214 0.3114973321411898 0.2229050397409754 0.03407981927082546 0.01347835575381735 1.7478039629734092e-09 8.757507280267593 -0.33604774283392247 VPPAVIIPPAAPLS(ph)GR ddPTM_A459_Selumetinib_30min_R2 2 VPPAVIIPPAAPLSGR 16 0 F5GWT4;Q9H4A3-2;Q9H4A3;Q9H4A3-5;Q9H4A3-6;Q9H4A3-7;Q9H4A3-4 F5GWT4 WNK1 Serine/threonine-protein kinase WNK1 1 VPPAVIIPPAAPLS(1)GR;VPPAVIIPPAAPLS(1)GR 123.76 0.0013412 2387300.0 6690.6 2422.2 4919.9 6310.6 9787.8 2664.52 5649.6 3885.9 2373.97 4996.4 True False 6318.763236593879 2607.974951399443 4603.358990382099 5451.085393607803 8558.16905995779 3031.5334438956843 5912.317594470025 3897.207325654623 2848.830334263904 4852.140949793775 1.302262918982689 0.5374895285163319 0.948727384058732 1.1234392096213701 1.7637923441448107 0.6247826423971732 1.2184966709842404 0.8031933461908731 0.587128519913459 1.0 12.244405744562997 -7.87541856856262 7.167758237941788 0.7624683454435147 1.059287206840528 0.12107269888602812 0.33846957729287597 0.47932613478971364 28.006857986229925 0.18813104742528378 0.08973388161859965 1.3322368170475586e-08 7.87541856856262 0.2968188613970132 VPPELLGGS(ph)PPWK ddPTM_A459_Selumetinib_30min_R1 2 VPPELLGGSPPWK 13 0 E7EVA0 E7EVA0 MAP4 Microtubule-associated protein 1 VPPELLGGS(1)PPWK;VPPELLGGS(1)PPWK 98.421 0.012569 101070000.0 8266.2 11781.2 12532.900000000001 13311.7 10419.9 10591.900000000001 9731.6 8677.8 5274.5 8000.9 True False 8458.786376774746 10401.851627068716 10831.001018291881 10987.06148655671 9477.421884782765 10485.35510267573 8997.53757704389 8447.636554533023 8950.441265761925 9027.89345036567 0.93696125494615 1.1521903403332032 1.1997262792078232 1.2170127557400099 1.0497932808897836 1.161439837579278 0.9966375463458145 0.9357262135377613 0.9914207910151391 1.0 13.140173676216186 -7.348660955351644 5.120750026867312 0.972176819766184 1.125746085414902 0.43391342554944556 0.07739091297246607 0.21231284502027956 9.305657521309852 0.03395025570959742 0.022586449165037627 4.4806296108669926e-08 7.348660955351644 0.15356926564871798 VPPELLGGS(ph)PPWK ddPTM_A459_Selumetinib_30min_R2 2 VPPELLGGSPPWK 13 0 E7EVA0 E7EVA0 MAP4 Microtubule-associated protein 1 VPPELLGGS(1)PPWK;VPPELLGGS(1)PPWK 141.59 0.00082077 5701300.0 61715.0 56491.0 61565.0 65960.0 62447.0 49303.0 52787.0 51930.0 41682.0 51916.0 True False 58285.12736471938 60823.678052805684 57603.974926903786 56976.13421265332 54601.8495767368 56094.040721926984 55241.700095456166 52081.107702525725 50019.56469238791 50417.050186032626 1.1560598478025694 1.2064108833891292 1.1425494889993029 1.1300965447684561 1.0830036540270165 1.1126006086224198 1.095694807443537 1.0330058484253428 0.9921160501818721 1.0 15.621624090636102 -7.000943054416534 0.4231791606249536 0.9843594536894059 1.1949945073780177 0.866260436059096 0.024131138802941998 0.4423046879599897 0.17346184703918283 0.026430938506081088 0.03486043655137399 9.978308928789038e-08 7.000943054416534 0.2106350536886118 VPQALNFS(ph)PEESDSTFSK ddPTM_A459_Selumetinib_30min_R1 1 VPQALNFSPEESDSTFSK 18 0 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 VPQALNFS(0.998)PEES(0.002)DSTFSK 142.58 0.00030030000000000004 8985200.0 2687.3 2843.5 2515.9 2912.2 2653.1 2295.8 2960.1 2553.7 1496.3 2630.3 True False 2749.908861424449 2510.5816980927143 2174.254598849472 2403.6389387644285 2413.1275734428496 2272.7063364196188 2736.8172738098165 2485.9675804133512 2539.1118145719183 2967.9246262916436 0.9265426881343679 0.8459048035965896 0.7325841699578993 0.8098719615287948 0.81306902205869 0.7657560829835882 0.9221316638453212 0.8376114266484971 0.8555176206561831 1.0 11.5352387382596 -9.263663791975898 0.5736430951300846 1.0081986942631331 0.8188976916374638 0.4488417564401874 0.056350112469103784 2.582990446723087 1.233529732556817 0.10996114186898419 0.02564885336969979 5.449243414593943e-10 9.263663791975898 -0.1893010026256693 VPS(ph)GIFDVNSR ddPTM_A459_Selumetinib_30min_R2 2 VPSGIFDVNSR 11 0 Q5VZ89-3;Q5VZ89;Q5VZ89-7;X6RAE7;Q5VZ89-5 Q5VZ89-3 DENND4C DENN domain-containing protein 4C 1 VPS(1)GIFDVNSR;VPS(1)GIFDVNSR 102.33 0.014387 5955900.0 7967.1 6062.799999999999 5969.8 7621.799999999999 10077.0 6238.8 5992.9 9965.3 5674.8 6819.8 True False 7524.320476828259 6527.797265025405 5585.709567426785 6583.697691661633 8811.037170476993 7098.138069812347 6271.581724706069 9994.297373155772 6809.918567159995 6622.8946540316165 1.1361075284880018 0.985641114048474 0.8433939929916511 0.9940815965801113 1.3303906570691666 1.0717576589401783 0.9469547761700106 1.509052747362039 1.0282389986400478 1.0 12.693246195087847 -6.041543775057938 23.466390170960818 1.1596101993721057 0.976545376962292 0.168030687325321 0.1703591408672242 382.6059201686866 216117.70252949247 0.04966720256709442 0.06413067018140402 9.087746937804416e-07 6.041543775057938 -0.1830648224098137 VPS(ph)PGMEEAGCSR ddPTM_A459_Selumetinib_30min_R1 4 VPSPGMEEAGCSR 13 0 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 VPS(1)PGMEEAGCSR;VPS(1)PGMEEAGCSR;VPS(1)PGMEEAGCSR;VPS(1)PGMEEAGCSR 160.46 0.00036396 300130000.0 2613.02 2991.86 2711.49 2730.04 2520.5099999999998 2483.9 3013.7400000000002 2510.73 1272.21 2100.2799999999997 True False 2673.8982819481685 2641.571640322021 2343.2845511484375 2253.2897631977344 2292.530315532184 2458.9142212007514 2786.411165424006 2444.1372843995805 2158.847451457955 2369.8713964596477 1.1282883476051513 1.1146476742443772 0.9887813130489155 0.9508067680651049 0.9673648616363725 1.0375728509463107 1.1757647143159866 1.0313375181669684 0.910955528929991 1.0 11.210593056560322 -5.248660795207082 19.584957354456815 1.0125213526689285 1.1214686082083687 0.3147377883624721 0.06678835653825592 59.103478866376925 90572.87798882947 0.01874791233738066 0.04835831945821142 5.640780557975468e-06 5.248660795207082 0.10894725553944018 VPS(ph)PGMEEAGCSR ddPTM_A459_Selumetinib_30min_R2 3 VPSPGMEEAGCSR 13 0 Q96RL1-2;Q96RL1-3;Q96RL1;Q96RL1-4 Q96RL1-2 UIMC1 BRCA1-A complex subunit RAP80 1 VPS(1)PGMEEAGCSR;VPS(1)PGMEEAGCSR;VPS(1)PGMEEAGCSR 160.46 0.00036396 336310000.0 37254.3 29776.699999999997 41866.6 33250.5 35557.9 26198.5 28373.1 28464.6 18868.9 24110.100000000002 True False 35183.855146779 32060.477142818832 39172.948536907475 28721.724539688166 31090.798710340736 29807.10556869567 29692.50537023104 28547.42727343178 22643.207241116022 23413.97876743714 1.5026858739494011 1.3692878712014023 1.6730581728974245 1.2266913208118537 1.3278733622830516 1.2730474331064883 1.2681529126320779 1.2192471667025664 0.9670807113145133 1.0 14.515082493850183 -7.255964645544163 0.4185929637427063 0.9670681735133169 1.5250867963339685 0.6982227290236138 0.10949904260751732 0.6693535252627668 0.2723152059992607 0.11657292428134508 0.13038621629058467 5.546708650131278e-08 7.255964645544163 0.5580186228206516 VPS(ph)PGPPTLTSYSVLR ddPTM_A459_Selumetinib_30min_R2 1 VPSPGPPTLTSYSVLR 16 0 F8W1U0;F8W130;Q12815 F8W1U0 TROAP Tastin 1 VPS(1)PGPPTLTSYSVLR 167.92 1.3927e-05 8846200.0 4826.0 6132.9 5675.7 3433.6 3300.4 5016.2 3075.1 1619.8 3610.2 3886.1 True False 4557.790240008678 6603.27370961838 5310.531641234917 2965.9377567096235 2885.7742460496434 5707.136017470133 3218.0982431950524 1624.5133498276741 4332.3408774161235 3773.898195699619 1.2077141469269914 1.749722267851012 1.4071740587189927 0.7859082579623712 0.7646666911518709 1.5122654935348947 0.8527252396108872 0.4304603000893923 1.1479750254929646 1.0 11.88183979012819 -5.684866366669945 5.791412607667714 0.9191017626939726 1.498174709832474 0.40756171089042303 0.2909520348387279 0.1955054551449355 11.045096948703025 0.08129739134409718 0.14163870063118209 2.0660157754358285e-06 5.684866366669945 0.5790729471385014 VPS(ph)PPDEHQEAENAVSSGNR ddPTM_A459_Selumetinib_30min_R1 1 VPSPPDEHQEAENAVSSGNR 20 0 Q9BXS6-4;Q9BXS6-6;Q9BXS6-3;Q9BXS6-5;Q9BXS6-2;Q9BXS6;Q9BXS6-7 Q9BXS6-4 NUSAP1 Nucleolar and spindle-associated protein 1 1 VPS(1)PPDEHQEAENAVSSGNR 69.122 0.008273299999999999 3855800.0 770.28 890.18 906.17 913.33 1195.6 981.66 968.28 986.93 615.88 842.1 True False 788.2260252960311 785.9573117665451 783.1170912355129 753.8340608274558 1087.4581911003245 971.7853916759657 895.2418600332996 960.7534103995566 1045.1033779045322 950.1917377486192 0.8295441793291647 0.8271565417194529 0.8241674391855139 0.793349416627835 1.1444618469078083 1.0227255753438884 0.942169695302216 1.0111153067653085 1.0998868295579967 1.0 9.892074851837187 -6.246427392306463 24.991803000228035 1.0318544179013032 0.8195697497281315 0.8043811438164558 0.052674518415819015 367.7792068612424 612274.9677455642 0.01622025225616475 0.020855055447723633 5.669863554362583e-07 6.246427392306463 -0.2122846681731717 VPS(ph)PPPGHK ddPTM_A459_Selumetinib_30min_R2 1 VPSPPPGHK 9 0 P11387 P11387 TOP1 DNA topoisomerase 1 1 VPS(1)PPPGHK 73.84100000000002 0.041839 3868400.0 58686.0 49642.0 57665.0 43216.0 38226.0 41768.0 45476.0 55585.0 39746.0 55733.0 True False 55424.46705867163 53449.38177581171 53954.896680904836 37329.90624824179 33423.7081352241 47521.162867846695 47590.724108984454 55746.74314740789 47696.31059602828 54123.84347827565 1.0240305103409373 0.9875385475398719 0.9968785144122547 0.6897127744304661 0.6175412902566645 0.8780079132207388 0.8792931368240048 1.0299849302051811 0.8812439681075629 1.0 15.723976672118924 -9.978223268070426 18.30802562994012 0.999999999883718 0.8832838695580321 0.061389217387334716 0.13162082262731406 0.0 0.0 0.1422171944719985 0.034492736152179876 1.0514212058078763e-10 9.978223268070426 -0.11671613032568595 VPS(ph)PYVR ddPTM_A459_Selumetinib_30min_R2 2 VPSPYVR 7 0 A0A087WVB5;Q75MD7;A0A2R8Y8C6;Q8WXX7-2;Q8WXX7;A0A2R8Y568;A0A024RDL5;A0A2R8Y522;Q8WXX7-5 A0A087WVB5 AUTS2 Autism susceptibility gene 2 protein 1 VPS(0.98)PY(0.02)VR;VPS(0.997)PY(0.003)VR 85.86200000000002 0.04446 0.0 77985.0 76296.0 72911.0 78854.0 76340.0 61165.0 69069.0 67767.0 49900.0 63577.0 True False 73650.90589868977 82147.65786969353 68219.98563949451 68113.94916926259 66749.48671174093 69589.92354941211 72280.84535762708 67964.1907505692 59881.394322493084 61741.36681711604 1.1928939979066377 1.3305124603577845 1.1049315743457506 1.1032141444329013 1.0811144966948891 1.1271199057763697 1.1707036802688546 1.100788567766661 0.9698747761750663 1.0 15.913949800928924 -1.5228787452808645 0.16577663449041202 0.9850419567242262 2.0573854752663756 0.5343996107239827 0.06528574617297755 51.560392125988436 0.5480574275889767 0.18894349306559333 13.618880468176249 0.029999999999963597 1.5228787452808645 1.0723435185421493 VPS(ph)SDEEVVEEPQSR ddPTM_A459_Selumetinib_30min_R2 2 VPSSDEEVVEEPQSR 15 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VPS(0.5)S(0.5)DEEVVEEPQSR;VPS(0.98)S(0.02)DEEVVEEPQSR 173.19 3.3961e-05 21174100.0 9979.0 10179.2 13703.6 15979.1 13803.3 8964.0 8807.2 11392.3 6826.4 8338.8 True False 9424.407129102074 10959.911908713246 12821.92529535156 13802.719014515009 12069.206050932318 10198.709632909831 9216.752251135722 11425.44970690321 8191.8707455524345 8098.037177195644 1.1637890667681217 1.3534035061702039 1.583337420512041 1.704452413899006 1.490386594534244 1.2594051385229195 1.1381464482640828 1.410891239061939 1.0115871990092895 1.0 12.983356550945496 -6.874049061413971 3.910718937291426 1.177035163581609 1.4737191012489739 0.43185758173215816 0.17080529198087005 0.2506361419256671 7.134757359917363 0.06610446052934833 0.05819211580168818 1.336444532444951e-07 6.874049061413971 0.2966839376673649 VPS(ph)TPPPK ddPTM_A459_Selumetinib_30min_R2 1 VPSTPPPK 8 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 VPS(0.904)T(0.096)PPPK 91.265 0.027107 24129000.0 193830.0 183840.0 189780.0 202790.0 194480.0 154210.0 176100.0 166820.0 133880.0 173790.0 True False 183057.70456296782 197939.9368612313 177569.76141684066 175169.65216773763 170047.68372674062 175451.0277209977 184288.9989355299 167305.4185814622 160659.74091974698 168772.2311393525 1.084643506382398 1.1728228958340636 1.0521266455867624 1.0379056494376904 1.0075572419631937 1.039572840487785 1.0919391045044933 0.9913089223980267 0.9519323163245549 1.0 17.36471802484946 -4.634541729911634 0.33524517199995585 0.9897644418993904 1.2538883036930295 0.49656178273738527 0.042081199803676875 6.727113488270999 0.5652875699640476 0.044517120343460254 0.7400956039422768 2.3198412690319734e-05 4.634541729911634 0.2641238617936391 VPS(ph)VESLFR ddPTM_A459_Selumetinib_30min_R1 2 VPSVESLFR 9 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 VPS(0.974)VES(0.026)LFR;VPS(1)VESLFR 128.51 0.004305600000000001 140828000.0 2079.73 2514.2 2577.5 2842.6000000000004 2821.8 2196.5 2366.6 2112.9 1092.31 1870.84 True False 2128.183662549871 2219.8362951801296 2227.4896571940517 2346.19327221062 2566.568688229255 2174.4052042624317 2188.085456639408 2056.8590283335434 1853.5702908340904 2110.980537524791 1.008149352738823 1.051566443044035 1.0551919440270503 1.1114234501477807 1.2158182619905435 1.0300451215016926 1.0365256418730537 0.9743619099138132 0.8780612885268357 1.0 11.043697562283251 -7.644937900953418 1.9302987898792106 0.9370130960212636 1.0839332643154498 0.47995299045095186 0.06011282786288044 0.30529644168462877 2.2437605304478963 0.04226793414759825 0.019177129084447252 2.2649681484730944e-08 7.644937900953418 0.1469201682941862 VPS(ph)VESLFR ddPTM_A459_Selumetinib_30min_R2 3 VPSVESLFR 9 0 Q13439-3;Q13439-4;Q13439;Q13439-5;E7EVX2;Q86W71 Q13439-3 GOLGA4 Golgin subfamily A member 4 1 VPS(0.797)VES(0.203)LFR;VPS(1)VESLFR;VPS(0.977)VES(0.023)LFR 126.03 0.0049031000000000005 49026000.0 7233.700000000001 3453.21 4234.99 7278.099999999999 6530.2 3489.6000000000004 3270.3999999999996 5680.53 3731.6499999999996 6654.200000000001 True False 6831.679912795436 3718.060103179784 3962.5153541084755 6286.810224577203 5709.8178952712915 3970.2607245651657 3422.4800801746615 5697.0594018376305 4478.084271012649 6462.075956312093 1.0571958545492364 0.5753662024891582 0.6131954159774197 0.9728777976427696 0.8835887931174806 0.6143940045593326 0.5296254800025395 0.8816144286067696 0.6929792068814202 1.0 12.657781993041711 -10.604665983981345 4.119614372351662 1.0000332188925336 0.7509756963900818 0.14917505641436846 0.17277158602373027 20654747.553986702 11815385.3288423 7021.07882408725 0.042041474518782755 2.4850436183190426e-11 10.604665983981345 -0.24905752250245183 VPS(ph)WGLEDNVVCSQPAR ddPTM_A459_Selumetinib_30min_R1 4 VPSWGLEDNVVCSQPAR 17 0 H7C3L5;B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 H7C3L5 TAX1BP1 Tax1-binding protein 1 1 VPS(1)WGLEDNVVCSQPAR;VPS(1)WGLEDNVVCSQPAR;VPS(1)WGLEDNVVCSQPAR;VPS(1)WGLEDNVVCSQPAR 232.62 1.2839e-16 48494700.0 921.1800000000001 1089.96 1142.7 1062.4 1607.0 1053.92 1167.02 1034.9 459.15 968.38 True False 942.641701695744 962.3469764913428 987.5276164018011 876.8717837179204 1461.6471337388941 1043.3185216827965 1078.9907418268076 1007.4510901710364 779.1440150108233 1092.681005819984 0.8626870025880559 0.880720879529855 0.9037657021050968 0.8024956771897822 1.3376704875015428 0.9548244328635106 0.9874709417293268 0.9219992704229464 0.7130571601966558 1.0 10.093656570858148 VPS(ph)WGLEDNVVCSQPAR ddPTM_A459_Selumetinib_30min_R2 2 VPSWGLEDNVVCSQPAR 17 0 H7C3L5;B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 H7C3L5 TAX1BP1 Tax1-binding protein 1 1 VPS(1)WGLEDNVVCSQPAR;VPS(1)WGLEDNVVCSQPAR 140.75 0.00050311 11579400.0 3468.0 3174.0 4545.7 5563.6 4767.8 5205.6 5202.8 5135.8 3746.8 4844.0 True False 3275.2624435039565 3417.4355939814354 4253.234610983944 4805.828082254675 4168.826339327201 5922.624148268116 5444.740509152616 5150.7443277225375 4496.264694339021 4704.1411337765285 0.6962508883900227 0.7264738656422679 0.9041468973889836 1.0216164748434133 0.8862035004422641 1.2590234816176482 1.1574356198751052 1.0949383067483505 0.9558099058837926 1.0 12.199715629263462 -5.447987119095092 1.0043000136677174 1.0858186565534538 0.6372609830504733 0.6680747074386506 0.09703013570507064 0.49505955732460055 0.7784255566961238 0.036818327756853016 0.1906726620554684 3.5646170570251095e-06 5.447987119095092 -0.4485576735029805 VPSAPGQES(ph)PIPDPK ddPTM_A459_Selumetinib_30min_R1 1 VPSAPGQESPIPDPK 15 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 VPSAPGQES(1)PIPDPK 138.98 0.00039539 14192000.0 3294.4 3939.3 3883.7 4674.5 3408.6 2987.3 3854.8 3591.5 1831.1 3244.2 True False 3371.153110213488 3478.084924669116 3356.3148716370674 3858.186326232511 3100.2927318372076 2957.250474251383 3564.0293324827153 3496.241753163859 3107.242961747402 3660.6246711840295 0.9209229060686761 0.950134263162284 0.916869434350249 1.0539693830410044 0.8469299669650147 0.8078540522142249 0.973612334675636 0.9550942987096788 0.8488286128340943 1.0 11.837874144406662 -2.2322149080542397 20.07253378929016 0.9257530413661305 0.24928061756386188 0.0 0.0719935910622578 0.0 0.0 0.0165608161349976 0.0 0.005858481892642368 2.2322149080542397 -0.6764724238022686 VPSAPGQES(ph)PIPDPK ddPTM_A459_Selumetinib_30min_R2 1 VPSAPGQESPIPDPK 15 0 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 VPSAPGQES(1)PIPDPK 125.61 0.0012149 4537100.0 50700.0 42334.0 47778.0 49392.0 49950.0 34642.0 38394.0 33878.0 32691.0 40690.0 True False 47882.29696818069 45580.88167473537 44704.01549675318 42664.72439404756 43674.83444133427 39413.621051234084 40179.39707626771 33976.57937119519 39230.11346285814 39515.173974683494 1.2117445566317848 1.153503251787226 1.1313126325951155 1.0797048349421898 1.1052674213029097 0.997430027170968 1.0168093174032278 0.8598362591788977 0.992786049429822 1.0 15.270119139530205 -6.422544437140514 0.7104862661066547 0.9445292697533926 1.188604706695518 0.7706570083516946 0.04618062295234101 0.3343675177102687 0.3730288698888825 0.02947942662341642 0.04372188111131992 3.7796846147782666e-07 6.422544437140514 0.24407543694212552 VPSPLEGSEGDGDT(ph)D ddPTM_A459_Selumetinib_30min_R1 2 VPSPLEGSEGDGDTD 15 0 F5H1S9;Q9Y606-2;Q9Y606;F5H168 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 1 VPSPLEGSEGDGDT(1)D;VPSPLEGSEGDGDT(1)D 161.48 2.999e-05 2226200.0 1111.75 1159.8600000000001 1554.1100000000001 1457.3400000000001 943.91 1032.24 1103.44 986.94 682.75 697.02 True False 1137.651611911075 1024.0630519957149 1343.0703981151694 1202.8429266598969 858.5335071608453 1021.8566027989307 1020.2066324153599 960.7631451670723 1158.5768839129692 786.4893065497479 1.4464934264673501 1.3020686275928912 1.7076778882183263 1.5293824297963463 1.0916022633888671 1.2992631867834494 1.2971652938180522 1.2215844985634283 1.4730993470153246 1.0 9.619283340040573 -6.242181224230481 24.84323682469927 1.2483078336777385 1.4976152834436873 0.4235438703915738 0.1511389058103517 805.185628364083 1038698.4519782253 0.04423380791433507 0.057010848256425266 5.725570621080723e-07 6.242181224230481 0.24930744976594887 VPSS(ph)DEEVVEEPQSR ddPTM_A459_Selumetinib_30min_R1 2 VPSSDEEVVEEPQSR 15 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VPS(0.046)S(0.954)DEEVVEEPQSR;VPS(0.043)S(0.957)DEEVVEEPQSR 214.89 2.2473000000000005e-07 21778000.0 1693.8500000000001 1985.85 2493.75 2212.66 2041.46 1997.02 1785.08 2193.26 1283.6000000000001 2082.55 True False 1733.3134093416445 1753.345758803381 2155.112447188231 1826.2604677723034 1856.8103034490357 1976.9317919490836 1650.4299784238463 2135.0876200874764 2178.175449565269 2349.865578254826 0.7376223667350896 0.746147258391494 0.9171215864989042 0.7771765690225617 0.7901772427459586 0.8412956937806166 0.70235080410411 0.9085998960302833 0.926936191466294 1.0 11.198362515864353 -7.93336455811245 6.584541666011195 0.9489784095764738 0.7927434338347014 0.6076950059608104 0.05882379976374761 0.1437771931954818 11.038486376972818 0.03291260001435008 0.015548005170069849 1.1658305776166494e-08 7.93336455811245 -0.15623497574177247 VPSS(ph)DEEVVEEPQSR ddPTM_A459_Selumetinib_30min_R2 2 VPSSDEEVVEEPQSR 15 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VPS(0.049)S(0.951)DEEVVEEPQSR;VPS(0.347)S(0.653)DEEVVEEPQSR 236.03 1.6526e-15 56222000.0 20562.0 20746.6 20423.4 33704.0 37098.0 18916.5 23105.0 24910.0 23371.2 27462.0 True False 19419.24635620772 22337.797509166725 19109.380679316593 29113.457057357013 32437.41757967204 21522.076168110092 24179.42828168894 24982.48397592749 28046.093045888796 26669.100705155033 0.7281552749341134 0.8375909542704946 0.7165363725827779 1.091654997265412 1.2162921404170939 0.8070041958313937 0.906645805158895 0.9367576451911809 1.0516324999465616 1.0 14.70288155689095 -5.7546177110837595 24.999282423505516 0.9956942386477751 0.7684438381682969 0.5085995294520833 0.10822456046825506 149.24493139439366 546929.4700509366 0.03184807504257687 0.05362578082741835 1.759471712330284e-06 5.7546177110837595 -0.2272504004794782 VPT(ph)ANVSVVDLTCR ddPTM_A459_Selumetinib_30min_R1 2 VPTANVSVVDLTCR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VPT(1)ANVSVVDLTCR;VPT(1)ANVSVVDLTCR 164.93 0.00060071 51431000.0 441.2 1484.96 1013.07 1124.6100000000001 811.91 856.1299999999999 910.88 1020.54 251.0 740.2 True False 451.47910157424445 1311.100192860825 875.5006583951804 928.2179750442501 738.4728838543525 847.5181095038454 842.1715882463047 993.4719640188898 425.92866768532457 835.2118801585658 0.5405563693472974 1.569781541675283 1.0482377935392462 1.1113562882606831 0.8841743052243853 1.0147342604165823 1.0083328652921193 1.1894849530041145 0.5099648098928641 1.0 9.705998422903727 -8.24774642890166 24.965476753645795 0.7549823587009733 1.0578864057415234 0.15999723939128696 0.2654238439240071 1118.0992797011213 2038568.1210653102 0.16955408915845802 0.06332905286771243 5.652669203295027e-09 8.24774642890166 0.3029040470405501 VPT(ph)ANVSVVDLTCR ddPTM_A459_Selumetinib_30min_R2 1 VPTANVSVVDLTCR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VPT(1)ANVSVVDLTCR 128.99 0.0025476 11977000.0 9259.7 6749.6 7783.6 9031.0 7709.8 6632.7 9159.3 11020.0 5931.5 9294.0 True False 8745.082943516029 7267.27261661534 7282.811650142912 7800.9622206560425 6741.225997513498 7546.294219344159 9585.225598808636 11052.06637554079 7117.965739957263 9025.658071287995 0.968913609893497 0.805179252218035 0.8069009032494434 0.8643095228116499 0.7468957880155436 0.8360935191363031 1.0619974214734227 1.224516405147134 0.7886367601937643 1.0 13.139816409079858 -7.256319976043169 23.621644984115076 1.037497355086573 0.8321892205060311 0.3762688814849573 0.11282666012964948 185.85295166580434 857555.6930245733 0.04258667283805431 0.03189264054146799 5.542172307225271e-08 7.256319976043169 -0.20530813458054187 VPTANVSVVDLT(ph)CR ddPTM_A459_Selumetinib_30min_R1 2 VPTANVSVVDLTCR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VPTANVS(0.002)VVDLT(0.998)CR;VPTANVSVVDLT(1)CR 124.2 0.0035486 20915200.0 1462.6 1498.96 1728.5 1479.5900000000001 1729.71 1645.68 1491.92 1938.64 1047.08 1267.6100000000001 True False 1496.6757342758153 1323.4610663524018 1493.7791939708711 1221.2073818441256 1573.2580359051042 1629.1259533578864 1379.3832732483165 1887.2209696097966 1776.818284302589 1430.3200910670084 1.046392163280952 0.9252901323403137 1.044367063918205 0.8538000615883915 1.0999342355119022 1.138993966128638 0.9643878191064956 1.3194396005455977 1.2422522031254526 1.0 10.48212232825231 -6.898092967212829 1.1097902471573697 1.17525115499481 0.9729701065578694 0.2870355090738115 0.11393534744227661 0.5719786827077926 1.4748280890489316 0.06479147055424993 0.05122646878794575 1.264465640763574e-07 6.898092967212829 -0.2022810484369405 VPTANVSVVDLT(ph)CR ddPTM_A459_Selumetinib_30min_R2 3 VPTANVSVVDLTCR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 VPTANVSVVDLT(1)CR;VPTANVSVVDLT(1)CR;VPTANVSVVDLT(1)CR 183.31 0.00016198 14520700.0 18819.1 23013.1 24256.5 22372.9 22709.3 19766.199999999997 16245.699999999999 19997.1 15689.2 23430.7 True False 17773.20976082622 24778.130771220596 22695.86319848031 19325.672424594806 19856.354710282125 22488.814630301444 17001.15724024384 20055.288250301877 18827.478392874928 22754.19481073031 0.7810959653226146 1.0889478171970228 0.9974364457747152 0.8493235021210814 0.8726458956446291 0.9883370876167537 0.7471658470738994 0.8813886150277795 0.8274289004503187 1.0 14.473844914960395 -5.762579760435442 24.99555408933355 0.8745169539086084 0.9691388574357126 0.10038551961955533 0.09916507354299318 54.72707665533724 1199595.7131747578 0.0265546343179739 0.04204457991139778 1.7275086854370485e-06 5.762579760435442 0.0946219035271042 VPTANVSVVDLTCR ddPTM_A459_Selumetinib_30min_R1 2 VPTANVSVVDLTCR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 237.41 3.1587e-18 152441000.0 622.73 544.56 686.85 806.37 766.62 526.81 843.56 480.86 287.65 388.09000000000003 False True 637.2383973783527 480.80266204092436 593.5795425969869 665.5526169395897 697.2793563577543 521.5107697052088 779.929590045948 468.10603074658854 488.12104087523363 437.90513181672213 1.4551973728525707 1.0979607844425907 1.3554980279277014 1.5198557143608575 1.5923068849752346 1.1909218043223992 1.781046928612781 1.0689667618293783 1.1146730316910936 1.0 8.774474546628896 -7.902863732727546 24.98681461514351 1.0685451642785249 1.4137538676539239 0.45236140380337597 0.18421743912723165 12.709290641378578 3255.215337050281 0.1000432572951801 0.04805921160024506 1.2506513817808866e-08 7.902863732727546 0.345208703375399 VPTANVSVVDLTCR ddPTM_A459_Selumetinib_30min_R2 1 VPTANVSVVDLTCR 14 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 123.26 0.022919 64599000.0 3606.9 3806.4 6469.6 7700.4 8121.5 3342.9 1596.8 8060.4 2885.5 7066.7 False True 3406.442937564715 4098.338640494937 6053.352979567884 6651.592236069071 7101.204562868794 3803.354131175176 1671.0543639991738 8083.854429528942 3462.680627606287 6862.666009508378 0.49637311984074584 0.5971933698677157 0.8820701708608327 0.9692431814185829 1.0347588754909411 0.5542094174342076 0.24349929920586116 1.1779466490615427 0.5045678491141293 1.0 12.744553428335138 -11.940182799814991 2.1827389506404793 3.1956443586130097 0.7305443302349119 0.08411153612070776 0.27652187283896607 34387273.94266489 2559545.673583506 374139320.5402013 0.07474100523050639 1.147670451404848e-12 11.940182799814991 -2.4651000283780977 VPTT(ph)PASPVK ddPTM_A459_Selumetinib_30min_R2 1 VPTTPASPVK 10 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 VPTT(0.597)PAS(0.403)PVK 136.81 0.0042453000000000005 39187000.0 92977.0 74507.0 91594.0 91691.0 94080.0 71349.0 91565.0 92000.0 67246.0 74824.0 True False 87809.71055642082 80221.4473222353 85700.94176000677 79202.5276242027 82260.82931412873 81176.67710826456 95822.95393260544 92267.70476858017 80697.07901022777 72663.63670390054 1.2084409002846845 1.1040109050573994 1.179419936126131 1.0899884896615855 1.1320769651171756 1.117156817226945 1.3187194899572334 1.2697920026293879 1.1105565681919138 1.0 16.148945951790417 VPTTPAS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 2 VPTTPASPVK 10 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 VPT(0.006)T(0.152)PAS(0.842)PVK;VPT(0.002)T(0.111)PAS(0.887)PVK 100.04 0.017854 16500000.0 6619.1 9336.1 5825.7 7000.5 6059.799999999999 6506.0 7041.5 6600.7 3848.3999999999996 6880.700000000001 True False 6773.312151473435 8243.025071764861 5034.601938279489 5777.994090660114 5511.692159944587 6440.55554697536 6510.353985855823 6425.627993904691 6530.4537239848705 7763.904868693651 0.8724105029655145 1.0617112408220204 0.6484626001254196 0.7442123761663653 0.7099123769753222 0.8295510643034248 0.8385411846179989 0.8276283780620127 0.8411300543258304 1.0 12.922566725446181 -9.19155296317719 0.9497558942088816 1.000988240364904 0.8118114579168051 0.216825602863992 0.10425649945486412 4.850969962909164 5.491779988865793 0.11735988219593381 0.034881745542233535 6.433496022943445e-10 9.19155296317719 -0.18917678244809888 VPTTPAS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 3 VPTTPASPVK 10 0 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 VPT(0.002)T(0.028)PAS(0.97)PVK;VPT(0.009)T(0.202)PAS(0.788)PVK;VPTT(0.04)PAS(0.96)PVK 129.74 0.0028969 58656000.0 193831.0 168488.0 182553.0 172142.0 194387.0 152892.0 177858.0 189787.0 157163.0 174807.0 True False 183058.64898697112 181410.4878256912 170807.73872867823 148695.96263848653 169966.36721817128 173951.48518461062 186128.74941894092 190339.2487490707 188599.99150112167 169759.86770686888 1.0783387820675365 1.0686300023450768 1.0061726663431356 0.8759194069074426 1.001216421254869 1.0246914511324876 1.0964237421552239 1.1212264201203141 1.1109810230695087 1.0 17.373135911516556 -7.158047038811397 3.6009761124090067 1.092482443128137 1.0030819958238149 0.2586687782741005 0.059954437999546306 0.327075487588361 7.816380202881217 0.026440182085094095 0.019838458772376246 6.949490429797302e-08 7.158047038811397 -0.08940044730432217 VPTTPAS(ph)PVKNWGGFR ddPTM_A459_Selumetinib_30min_R2 1 VPTTPASPVKNWGGFR 16 1 Q6IE81-2;Q6IE81 Q6IE81-2 JADE1 Protein Jade-1 1 VPTT(0.001)PAS(0.999)PVKNWGGFR 109.95 0.0015838 8363700.0 19817.0 26527.0 24742.0 30885.0 24455.0 16053.0 15589.0 14705.0 10347.0 22066.0 True False 18715.65047373643 28561.53560225127 23150.12665705276 26678.40972040326 21382.744269526116 18264.155035375003 16313.919389017472 14747.7891154562 12416.68911933539 21428.89724564675 0.873383742485325 1.332851395703692 1.0803228179068185 1.244973524049304 0.9978462271953817 0.8523142757187536 0.7613046626714132 0.6882196944806478 0.579436682018615 1.0 14.38726998881861 -6.760775116142362 1.9380239057368849 0.7329189370684271 1.1438166533700993 0.5600553477644892 0.1499994419909018 0.21935086125318828 1.6986734464073636 0.05784009815995218 0.05306772654932819 1.7347020185997526e-07 6.760775116142362 0.41089771630167216 VPVAS(ph)PSAHNISSSGGAPDR ddPTM_A459_Selumetinib_30min_R1 1 VPVASPSAHNISSSGGAPDR 20 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 VPVAS(0.983)PS(0.017)AHNISSSGGAPDR 138.28 0.00010961 0.0 1104.6 1225.3 1522.6 1593.4 1232.4 1434.4 1136.8 946.05 733.57 978.52 True False 1130.3350308225527 1081.8413063734843 1315.8392830431278 1315.1426018224156 1120.9296375978922 1419.971238330995 1051.0502607570695 920.9576807965105 1244.8147121670256 1104.1225735919472 1.0237405319459512 0.9798199332652197 1.1917510922382655 1.1911201104638003 1.015222099799362 1.2860630443516108 0.951932589637922 0.8341081894562105 1.127424383795883 1.0 10.10868462570678 VPVAS(ph)PSAHNISSSGGAPDR ddPTM_A459_Selumetinib_30min_R2 2 VPVASPSAHNISSSGGAPDR 20 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 VPVAS(0.944)PS(0.056)AHNISSSGGAPDR;VPVAS(0.997)PS(0.003)AHNISSSGGAPDR 130.81 0.00010782 22107500.0 37178.0 24909.0 41970.0 58998.0 57516.0 43986.0 34232.0 33868.0 41801.0 48305.0 True False 35111.795595325864 26819.440204941267 39269.69589348089 50962.37062277329 50290.32588043612 50044.67223484734 35823.855829421154 33966.55027285076 50162.368017525725 46910.30913853737 0.7484878322083175 0.5717174049255792 0.8371229398106945 1.086378912410686 1.0720527492563894 1.0668160827304174 0.7636670166385972 0.7240743217560006 1.0693250361958657 1.0 15.517617387762693 -5.48823398661682 5.475575732062334 0.9580404974126496 0.6663367031339784 0.4790226038354354 0.12804133634789724 0.1786524380324072 14.566970379337745 0.03738103563824169 0.07605852338892492 3.2491219594500876e-06 5.48823398661682 -0.2917037942786712 VPVASPS(ph)AHNISSSGGAPDR ddPTM_A459_Selumetinib_30min_R1 3 VPVASPSAHNISSSGGAPDR 20 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 VPVAS(0.058)PS(0.942)AHNISSSGGAPDR;VPVAS(0.084)PS(0.91)AHNIS(0.005)SSGGAPDR;VPVASPS(0.998)AHNIS(0.002)SSGGAPDR 231.4 4.8582e-24 28823300.0 1805.02 2369.85 2039.9 2133.86 2187.6 1881.94 2471.88 1763.17 774.49 1448.53 True False 1847.0734540424812 2092.3868602866246 1762.8927843686315 1761.2214085131047 1989.7319662521497 1863.0093922648039 2285.4241014779955 1716.4050040166849 1314.2529634884747 1634.4629353770422 1.1300797430541878 1.2801678245484027 1.078576177049841 1.0775535929218374 1.2173613259655554 1.1398296969242927 1.3982722104070153 1.050133941165659 0.8040885694268126 1.0 10.67460094622488 -8.00049044057541 24.995805539355597 0.9103998950734236 1.185979171262786 0.5636720110240423 0.10139081937465895 11.62608906793609 592513.8811269284 0.05544437552192603 0.026149847909250307 9.988713562400718e-09 8.00049044057541 0.2755792761893625 VPVASPS(ph)AHNISSSGGAPDR ddPTM_A459_Selumetinib_30min_R2 2 VPVASPSAHNISSSGGAPDR 20 0 Q7KZI7-14;E9PC69;Q7KZI7-13;E7ETY4;Q7KZI7-15;Q7KZI7-16;Q7KZI7-3;Q7KZI7-9;Q7KZI7-8;Q7KZI7-11;Q7KZI7-6;Q7KZI7;Q7KZI7-12;Q7KZI7-4;Q7KZI7-5;Q7KZI7-2;Q7KZI7-7;Q7KZI7-10 Q7KZI7-14 MARK2 Serine/threonine-protein kinase MARK2 1 VPVAS(0.002)PS(0.998)AHNISSSGGAPDR;VPVAS(0.003)PS(0.997)AHNISSSGGAPDR 214.52 1.9626e-17 3815600.0 53710.9 55229.4 58974.9 61762.5 67233.5 49309.7 58129.4 59064.3 49189.9 65194.6 True False 50725.86319976841 59465.317389489064 55180.519141016084 53350.34095374479 58787.026654883906 56101.663586110415 60832.53228122093 59236.16733437873 59029.25448064136 63312.262502086516 0.801201239619208 0.9392385462062635 0.8715613209873452 0.8426541533243513 0.928525128176339 0.8861105474513966 0.9608333342883795 0.9356191832889648 0.9323510509310261 1.0 15.95019733161399 -1.5228787621886903 0.06980313533478653 1.112423560873652 0.4354609790922926 0.5749931438673146 0.036565129682500044 189.72427434465217 0.981971818859642 1.6701610539922398 12.632246353261872 0.029999998832012393 1.5228787621886903 -0.6769625817813594 VPVHDVTDASK ddPTM_A459_Selumetinib_30min_R2 2 VPVHDVTDASK 11 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 113.69 0.0097715 17989000.0 149178.0 139336.0 174134.0 177483.0 208176.0 134526.0 134068.0 133883.0 124596.0 146233.0 False True 140887.2839668492 150022.62316414496 162930.40802276385 153309.50922474745 182023.069762947 153055.735394559 140302.42765070204 134272.57736447614 149518.68150311316 142010.8733310368 0.9920880046870184 1.056416453509389 1.147309386957731 1.0795617661428838 1.2817544564960115 1.0777747633293957 0.9879696135918251 0.9455091304979009 1.0528678402996308 1.0 17.11564187106959 -7.168084335180961 4.651585515895196 0.9922601645604602 1.1143146865378928 0.3453819620024807 0.07416429488805346 0.25962023673709483 9.50349647725428 0.03048261737624254 0.02324984833909093 6.7907175159551e-08 7.168084335180961 0.1220545219774326 VPVLIS(ph)PTLK ddPTM_A459_Selumetinib_30min_R1 2 VPVLISPTLK 10 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 VPVLIS(0.984)PT(0.016)LK;VPVLIS(0.501)PT(0.499)LK 184.03 0.00017154 42015000.0 7472.799999999999 9307.8 7198.8 7995.299999999999 7821.0 7867.0 9271.5 8914.4 4701.299999999999 6612.9 True False 7646.901700462401 8218.03844892118 6221.242500177902 6599.070945368874 7113.5919309097 7787.865122664488 8572.143290472532 8677.96115394791 7977.762730633533 7461.730130100756 1.0248161709326178 1.1013583050624496 0.8337533509931291 0.8843888522245131 0.9533435016918315 1.0437076906933551 1.1488144359298589 1.1629958471616195 1.0691572318397167 1.0 12.865294467517677 -6.936920994841949 3.5534485601172823 1.1082087341859377 0.9565324354361533 0.3873281729828034 0.08002784750836434 0.24314361996665512 6.239210501915369 0.03238889617865554 0.027636153185705073 1.1563225767524746e-07 6.936920994841949 -0.1516762987497844 VPVLIS(ph)PTLK ddPTM_A459_Selumetinib_30min_R2 1 VPVLISPTLK 10 0 P42684-2;P42684-6;P42684-3;P42684;P42684-4;P42684-7;P42684-10;P42684-5 P42684-2 ABL2 Abelson tyrosine-protein kinase 2 1 VPVLIS(0.774)PT(0.226)LK 127.52 0.0032732 13567000.0 118160.0 87816.0 111070.0 102370.0 105700.0 78989.0 82996.0 99324.0 96774.0 96447.0 True False 111593.14023195734 94551.20482705513 103923.87712387247 88427.02940189997 92421.02103001079 89869.0177592497 86855.47845345408 99613.01639602665 116131.50409148207 93662.32451059963 1.1914410710501693 1.0094902653879245 1.109559021376963 0.9441045784838792 0.9867470352986129 0.9595001856811631 0.9273256766505381 1.0635334636047131 1.2398956004806354 1.0 16.51518122282132 -10.829580269929007 12.410707905298045 1.0000011124400283 1.038089732966226 0.01171254389522014 0.10036418096011886 2.736180920563719e-10 0.0 0.09942745611657072 0.02411470021500505 1.4805385844854706e-11 10.829580269929007 0.03808862052619766 VPVPGPGS(ph)GGNGPER ddPTM_A459_Selumetinib_30min_R2 4 VPVPGPGSGGNGPER 15 0 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 VPVPGPGS(1)GGNGPER;VPVPGPGS(1)GGNGPER;VPVPGPGS(1)GGNGPER;VPVPGPGS(1)GGNGPER 137.39 0.00040182 94268000.0 78018.0 56291.0 81753.0 71509.0 78469.0 67840.0 69921.0 66075.0 61004.0 62916.0 True False 73682.07189079921 60608.338695907005 76493.10098593617 61769.350840094456 68611.02269823942 77184.34420979508 73172.46504583304 66267.26731069495 73206.50459417573 61099.45160460034 1.2059367139270933 0.9919620733771634 1.2519441496947379 1.0109640793477053 1.1229400738692312 1.2632575609563026 1.1975961015061498 1.0845803942650365 1.198153218590653 1.0 15.898871810806645 -4.4564142419537305 22.85767808248977 1.1321580535623257 3.644634505977225 0.0545249256098842 0.09712390940089717 1717.9145512502375 631549.0996678045 0.022492548622274747 15206.02322419566 3.4961153889501476e-05 4.4564142419537305 2.5124764524148993 VQAEDEANGLQTT(ph)PASR ddPTM_A459_Selumetinib_30min_R2 2 VQAEDEANGLQTTPASR 17 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 VQAEDEANGLQT(0.084)T(0.852)PAS(0.064)R;VQAEDEANGLQT(0.055)T(0.927)PAS(0.018)R 139.49 0.00066882 0.0 16538.3 14101.2 16314.8 18446.2 17147.5 14710.6 18579.8 18966.8 18896.9 15992.099999999999 True False 15619.167494060408 15182.716697495602 15265.123530211149 15933.795738530125 14993.277749405 16736.85162046891 19443.79751517525 19021.99024787722 22676.80802350139 15530.366520534182 1.005717892968515 0.9776148346158527 0.9829210089811898 1.0259767995470377 0.9654168644108273 1.077685552259151 1.2519857460844048 1.2248255842981186 1.4601592302099384 1.0 13.922804257640237 -7.13444226873825 2.769457271192983 1.2563649523201859 0.9924895059357645 0.5368772968088159 0.10542387599778313 0.19618327634766164 2.9091677312721225 0.0425023610735367 0.03140031834487479 7.337662483214368e-08 7.13444226873825 -0.2638754463844214 VQAEDEANGLQTTPAS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 VQAEDEANGLQTTPASR 17 0 J3KP58;P30622-2;P30622-1;P30622;F5H1T5;F5H6A0 J3KP58 CLIP1 CAP-Gly domain-containing linker protein 1 1 VQAEDEANGLQT(0.001)T(0.266)PAS(0.733)R 182.98 6.7373e-08 4826500.0 650.38 1462.0 880.49 847.01 850.3 1026.5 1098.2 935.19 517.41 478.68 True False 665.532588580818 1290.8283603346392 760.9242941853695 699.095603846871 773.3905151326583 1016.1743419874285 1015.3618898341074 910.3857232747628 878.0069798687798 540.1232407380464 1.2321865425961067 2.389877463096753 1.4087975424749573 1.2943260928591005 1.4318778693467549 1.8813749628675234 1.8798707651362594 1.685514813305894 1.6255678586780218 1.0 9.077144816524463 -8.787895112262996 4.608068770816907 1.0000005654755417 1.6629489604908452 0.2617178102741694 0.32605714480868336 12.616433735985561 218.83283623816678 0.31505086815836447 0.08210039679375385 1.6296895762351693e-09 8.787895112262996 0.6629483950153034 VQAGPGS(ph)PR ddPTM_A459_Selumetinib_30min_R1 3 VQAGPGSPR 9 0 I3L0U5;Q6PK04;I3L4F6 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 VQAGPGS(1)PR;VQAGPGS(1)PR;VQAGPGS(1)PR 115.0 0.0083044 271602000.0 14444.2 20018.1 18653.6 19291.0 16511.9 15019.1 14522.5 13732.4 8293.3 11640.099999999999 True False 14780.72175647937 17674.37154583779 16120.543576890379 15922.188986918682 15018.401560412713 14868.021490251711 13427.05613286817 13368.172142878295 14073.12438133347 13134.220219175526 1.125359671897385 1.345673458408577 1.2273696731043782 1.2122675515728611 1.1434558968705537 1.1320064108979149 1.02229564517771 1.0178123953914833 1.071485337270893 1.0 13.681042929520569 -6.73801721647632 1.09518415053488 1.024010078182289 1.2437362888888606 0.721492294181407 0.05471203113539064 0.24610554414755387 0.629046941190351 0.02812148074276671 0.026018331393033948 1.828027747296005e-07 6.73801721647632 0.2197262107065716 VQAGPGS(ph)PR ddPTM_A459_Selumetinib_30min_R2 3 VQAGPGSPR 9 0 I3L0U5;Q6PK04;I3L4F6 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 VQAGPGS(1)PR;VQAGPGS(1)PR;VQAGPGS(1)PR 126.71 0.004739 575740000.0 1058960.0 1095610.0 1091470.0 1186910.0 1144000.0 831385.0 947480.0 859580.0 710801.0 1053610.0 True False 1000107.2425527548 1179639.7640586016 1021246.0085026823 1025250.8104660453 1000280.4925102383 945900.7371883902 991539.6973960036 862081.2354888709 852981.0614393266 1023189.5416924615 0.9774408374996424 1.1529044385142515 0.9981005149968946 1.0020145522306398 0.9776101609245055 0.9244628669911661 0.9690674669679425 0.8425430483416584 0.8336491204048153 1.0 19.964641992540713 -6.4244912834624905 0.8520803534590751 0.8929027512580489 1.061697619053859 0.4467188247077034 0.06361536497317842 0.5146025415000373 0.8192773387574152 0.034741770308927084 0.047544732606759954 3.7627790430374453e-07 6.4244912834624905 0.1687948677958101 VQAGPGS(ph)PRR ddPTM_A459_Selumetinib_30min_R2 3 VQAGPGSPRR 10 1 I3L0U5;Q6PK04;I3L4F6 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 VQAGPGS(1)PRR;VQAGPGS(1)PRR;VQAGPGS(1)PRR 77.64399999999998 0.027976 8652400.0 39931.7 52031.2 50149.3 49785.7 48988.1 27303.5 20620.2 21240.4 16649.199999999997 52748.7 True False 37712.45597326036 56021.82573332288 46922.74863642936 43004.80177487716 42833.77691882937 31064.309288504395 21579.080158151162 21302.2060474625 19979.505217516056 51225.707973418255 0.7362017523082334 1.0936271639699622 0.9160000025920234 0.8395160062442272 0.8361773533917075 0.6064203017872218 0.4212548935262906 0.4158499099420259 0.39002887432778294 1.0 15.644580397930557 -6.767203531348717 2.3889526372527987 0.5065005539520017 0.908672207163486 0.4179259040747211 0.18495394987291885 0.23983361779016982 2.80819207904648 0.06785169945749404 0.062486842681438524 1.7092141071632396e-07 6.767203531348717 0.4021716532114843 VQAYEEPSVAS(ph)SPNGK ddPTM_A459_Selumetinib_30min_R1 4 VQAYEEPSVASSPNGK 16 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 1 VQAYEEPSVAS(0.5)S(0.5)PNGK;VQAYEEPSVAS(0.5)S(0.5)PNGK;VQAYEEPSVAS(0.919)S(0.081)PNGK;VQAYEEPSVAS(0.993)S(0.007)PNGK 303.07 3.0001e-88 598280000.0 34242.1 39107.8 41248.8 40484.8 37913.1 33637.1 36569.2 35790.0 19075.5 30397.4 True False 35039.87430647197 34529.04059527704 35647.439523439774 33414.88967381711 34483.866799101466 33298.74131404316 33810.75580196817 34840.73293769583 32369.73028060323 34299.20238574978 1.0215944357070506 1.0067009782601462 1.0393081192538212 0.9742176887384393 1.0053839273367013 0.9708313604364667 0.9857592436614636 1.0157884298840443 0.9437458608090497 1.0 15.065887407040746 -5.7680208223612714 24.999937095631537 0.986039269393648 1.0209511589973952 0.413464851726945 0.020382426590250285 148.99021345854095 565949.3207145076 0.005391710151015052 0.008218914087007527 1.706000592402575e-06 5.7680208223612714 0.03491188960374714 VQAYEEPSVAS(ph)SPNGK ddPTM_A459_Selumetinib_30min_R2 3 VQAYEEPSVASSPNGK 16 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 1 VQAYEEPSVAS(0.715)S(0.285)PNGK;VQAYEEPSVAS(0.5)S(0.5)PNGK;VQAYEEPSVAS(0.5)S(0.5)PNGK 297.73 7.016899999999996e-88 287585000.0 421228.0 372366.0 434694.0 454626.0 448559.0 333942.0 378374.0 403692.0 308258.0 375567.0 True False 397817.83406928665 400925.27485459653 406726.26129904244 392705.1545264056 392207.00825166085 379939.4792763468 395969.14073385735 404866.6768851921 369918.21344815765 364723.4048697461 1.0907384301573944 1.0992584229624067 1.1151635893624563 1.0767204662027452 1.0753546468774877 1.0417194899023132 1.0856696758335813 1.1100649738389625 1.0142431456524341 1.0 18.476443257072397 -14.522878745235685 0.1052381388186326 0.7237591639677143 1.1331982494256816 0.5629177250380446 0.024782023007080507 136.81574117160022 0.9644830326912361 8.072008545177429 0.36502912431672063 3.000000000308448e-15 14.522878745235685 0.40943908545796726 VQAYEEPSVASS(ph)PNGK ddPTM_A459_Selumetinib_30min_R2 3 VQAYEEPSVASSPNGK 16 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 1 VQAYEEPSVAS(0.025)S(0.975)PNGK;VQAYEEPSVAS(0.188)S(0.812)PNGK;VQAYEEPSVAS(0.081)S(0.919)PNGK 260.07 4.5255e-39 317349000.0 282811.0 233847.0 287103.0 281485.0 285659.0 215634.0 251256.0 235301.0 208556.0 250952.0 True False 267093.4968021329 251782.31296338237 268631.1055541112 243146.25741129086 249771.96259613827 245335.6261694417 262939.90185431915 235985.6869538224 250273.0275415209 243706.36370839912 1.0959643923033422 1.033138031900744 1.102273660262459 0.9977017165715933 1.0248889638967196 1.0066853505023448 1.078920951645454 0.9683197572804677 1.026944983024649 1.0 17.894784397925974 -1.5228787459049116 0.28277059340793986 1.0043092407436718 1.64683113485205 0.3389758058365424 0.03466918461954788 61.343941077274906 0.86648272162079 0.03680579175654402 19.538731377775385 0.029999999956855955 1.5228787459049116 0.6425218941083781 VQDDEVGDGTTSVTVLAAELLR ddPTM_A459_Selumetinib_30min_R1 2 VQDDEVGDGTTSVTVLAAELLR 22 0 F8VQ14;F5GWF6;P78371-2;P78371 F8VQ14 CCT2 T-complex protein 1 subunit beta 0 ; 164.97 3.1485e-09 4619400.0 1020.0799999999999 923.2199999999999 1299.1999999999998 1179.09 1282.73 1075.05 1080.08 1104.88 577.93 1001.3 False True 1043.845879269844 815.1289732066663 1122.7757759947663 973.1840657605072 1166.7072979843754 1064.2359730673008 998.6086960226036 1075.5749932439612 980.704999662867 1129.8266084879378 0.9238991818991031 0.7214637777893763 0.9937593676408384 0.8613570068622588 1.032642787149256 0.9419462819092057 0.8838601326260629 0.9519823530120411 0.8680137220129358 1.0 10.141885667684306 -5.275987118784469 24.995166192054626 0.9383026249795025 0.8226814644974142 0.30974645287450153 0.0709208677400617 793.4105574460068 1363196.1512895306 0.017329354166659695 0.03632357143813798 5.2967915399262845e-06 5.275987118784469 -0.11562116048208826 VQDT(ph)SNTGLGEDIIHQLSK ddPTM_A459_Selumetinib_30min_R2 1 VQDTSNTGLGEDIIHQLSK 19 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 1 VQDT(0.488)S(0.488)NT(0.024)GLGEDIIHQLSK 109.18 0.00095961 1726000.0 11305.0 10554.0 10574.0 11916.0 13521.0 11007.0 9414.9 10844.0 8887.8 10533.0 True False 10676.71335750065 11363.457863541289 9893.680352100717 10293.02024375345 11822.37110072635 12523.11433840233 9852.711505270425 10875.55424467916 10665.608345880844 10228.884921979388 1.0437807677901418 1.1109185361078782 0.9672296078765733 1.0062700208540083 1.1557829803445092 1.2242892977995286 0.9632243964441658 1.0632199235432043 1.0426951155705197 1.0 13.320361261171044 VQDTS(ph)NTGLGEDIIHQLSK ddPTM_A459_Selumetinib_30min_R1 3 VQDTSNTGLGEDIIHQLSK 19 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 1 VQDT(0.129)S(0.723)NT(0.148)GLGEDIIHQLSK;VQDT(0.215)S(0.652)NT(0.133)GLGEDIIHQLSK;VQDT(0.124)S(0.753)NT(0.124)GLGEDIIHQLSK 183.69 1.1709e-13 169876000.0 17041.800000000003 22229.9 20577.800000000003 21884.8 19359.399999999998 18388.1 19353.8 18011.8 9219.900000000001 16278.400000000001 True False 17438.84078242964 19627.212973599864 17783.447785764416 18063.030508574873 17608.345688179674 18203.13240905896 17893.927284166224 17534.068553428035 15645.496905147107 18367.891205043506 0.9494198646843702 1.0685610424462102 0.9681812455902062 0.9834025205688869 0.95864819165222 0.9910300646848721 0.974196062270494 0.9546043341444379 0.851785146726649 1.0 14.164898381466136 -7.902509061735942 3.5491356615855363 0.92008016802314 0.9866788734313091 0.20668952184252243 0.04543450530754059 0.3031904404291059 7.304846714372785 0.02719297271435472 0.011633120362555292 1.2516731560755338e-08 7.902509061735942 0.06659870540816915 VQDTS(ph)NTGLGEDIIHQLSK ddPTM_A459_Selumetinib_30min_R2 1 VQDTSNTGLGEDIIHQLSK 19 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 1 VQDT(0.119)S(0.795)NT(0.086)GLGEDIIHQLSK 157.55 1.8492e-06 49454000.0 78105.0 71700.0 90148.0 107530.0 99610.0 84597.0 87895.0 88277.0 72952.0 96425.0 True False 73764.23677908789 77199.15944816274 84347.9758257212 92884.22850040374 87096.10127530141 96249.46885489435 91982.29166063834 88533.87145495585 87544.43844918883 93640.95970776267 0.7877347371203092 0.8244165767746084 0.9007594122161575 0.9919188012412458 0.9301068842856093 1.0278564973626114 0.9822869388321014 0.9454609578036667 0.9348947161840285 1.0 16.51485209997262 -5.367167906006391 1.9477859035478198 0.9724704726674938 0.7905652955782563 0.8345023745746204 0.02975152478437438 0.14030919331278455 0.9872136457504717 0.00869632461700541 0.029188685597050814 4.293703924056196e-06 5.367167906006391 -0.18190517708923748 VQDTSNT(ph)GLGEDIIHQLSK ddPTM_A459_Selumetinib_30min_R1 1 VQDTSNTGLGEDIIHQLSK 19 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 1 VQDT(0.048)S(0.436)NT(0.516)GLGEDIIHQLSK 165.0 1.4225e-07 131130000.0 2702.1 3813.1 3998.5 3981.5 3261.1 2875.8 3465.3 2975.3 1702.6 2421.5 True False 2765.053672628662 3366.6604793379015 3455.5256621883295 3286.2057670113923 2966.1340807939687 2846.872063017482 3203.9096310709656 2896.3853788635474 2889.1878470160696 2732.323112407413 1.0119790225660428 1.2321604513207014 1.2646841241055535 1.2027149176057588 1.085572225087445 1.041923647349724 1.1725954432409877 1.0600449726136456 1.057410755666611 1.0 11.415912385092494 -6.290174104319841 7.273400710386437 1.076089871050187 1.1879909529345924 0.3293596201470673 0.07482332274620705 0.2580202816289679 52.80310608767871 0.023374517486874087 0.026998845607743464 5.12655824191431e-07 6.290174104319841 0.1119010818844055 VQDTSNT(ph)GLGEDIIHQLSK ddPTM_A459_Selumetinib_30min_R2 1 VQDTSNTGLGEDIIHQLSK 19 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 1 VQDT(0.098)S(0.411)NT(0.49)GLGEDIIHQLSK 176.9 1.1108e-12 46997000.0 48554.0 47289.0 54266.0 60793.0 67866.0 54137.0 49757.0 50937.0 45143.0 56040.0 True False 45855.56305706208 50915.9142418992 50774.58464035346 52512.888526225564 59340.066350262125 61593.88034324402 52070.79909162507 51085.21823692572 54172.86140080769 54421.97959059386 0.8425927061460223 0.9355762988581062 0.9329793774927143 0.9649205876241544 1.0903694940291788 1.1317831656731894 0.9567972257412121 0.9386872477118628 0.9954224710004995 1.0 15.731901814887314 -5.434661732276649 1.3890683189549238 1.0160607075250785 0.8672823228148983 0.4494946013550244 0.058130727514591786 0.5642778530707027 1.910430513198478 0.0207602450711146 0.08343525648169339 3.6756848452740586e-06 5.434661732276649 -0.14877838471018023 VQEHEDS(ph)GDS(ph)EVENEAK ddPTM_A459_Selumetinib_30min_R1 1 VQEHEDSGDSEVENEAK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 2 VQEHEDS(1)GDS(1)EVENEAK 164.58 9.414e-05 12617000.0 3076.0 3816.5 3807.2 3999.3 3524.1 3359.8 3227.7 2970.2 1746.6 2593.7 True False 3147.664815145911 3369.6624057572876 3290.2031514526457 3300.8973311587747 3205.34577723039 3326.00346245432 2984.231990363822 2891.420647430681 2963.8526333832183 2926.626659777455 1.0755265980476183 1.1513810258304424 1.1242305677974098 1.1278846654837005 1.0952356244421448 1.1364631875208961 1.019683183843732 0.9879704463741026 1.012719754834938 1.0 11.51502300224308 -7.334024478479364 4.710634804132251 1.0013913000059618 1.119607753447499 0.87639974132364 0.020901070368282752 0.0689526119295543 2.90516770547725 0.008623702903158576 0.005744799678592001 4.634207988514253e-08 7.334024478479364 0.1182164534415373 VQEHEDS(ph)GDS(ph)EVENEAK ddPTM_A459_Selumetinib_30min_R2 4 VQEHEDSGDSEVENEAK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 2 VQEHEDS(1)GDS(1)EVENEAK;VQEHEDS(1)GDS(1)EVENEAK;VQEHEDS(1)GDS(1)EVENEAK;VQEHEDS(1)GDS(1)EVENEAK 173.49 7.1252e-06 64420000.0 260163.0 244105.9 241896.0 249777.0 226993.0 195273.7 227120.5 232614.9 176465.9 236600.6 True False 245704.1819750057 262828.03760581964 226332.6747164512 215756.9417106417 198476.10999683282 222170.87965684364 237682.0532807331 233291.7708475301 211764.01086921117 229769.32591581438 1.069351537659251 1.1438778285928284 0.9850430374652257 0.939015427105763 0.8638059462713176 0.9669301103239745 1.0344377010872978 1.0153303532474405 0.921637429300723 1.0 17.80982668624631 -5.353268116842695 5.253772703625442 0.9628660181134147 1.1058451066955117 0.5679443411911466 0.04931595827119981 0.15682265824124034 6.828260658566669 0.014143005992082697 0.030500127779614767 4.43334861400621e-06 5.353268116842695 0.14297908858209707 VQEHEDS(ph)GDSEVENEAK ddPTM_A459_Selumetinib_30min_R1 2 VQEHEDSGDSEVENEAK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 VQEHEDS(0.982)GDS(0.018)EVENEAK;VQEHEDS(0.993)GDS(0.007)EVENEAK 265.54 5.2606e-41 38425000.0 5515.799999999999 4720.1 6144.4 5962.6 6055.0 3749.2 4066.7999999999997 4684.2 1870.0500000000002 4277.8 True False 5644.307408121524 4167.46849768504 5310.024228773281 4921.34384186415 5507.326319097076 3711.4864520012306 3760.0380018005367 4559.959799574037 3173.3382669519556 4826.89729930061 1.1693448312934587 0.8633845386121811 1.1000905756877557 1.019566718889425 1.1409661274324308 0.7689176342200204 0.7789761763411343 0.9446979118935779 0.6574281718013255 1.0 12.236880415905771 -6.767466583675629 24.999991837170835 0.8233583396571121 1.0479500168318021 0.4824654671584895 0.11805481273616449 125.83114786561606 521926.3443350305 0.03867058972539182 0.034978564824672424 1.708179149020795e-07 6.767466583675629 0.22459167717468997 VQEHEDS(ph)GDSEVENEAK ddPTM_A459_Selumetinib_30min_R2 2 VQEHEDSGDSEVENEAK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 VQEHEDS(1)GDSEVENEAK;VQEHEDS(0.994)GDS(0.006)EVENEAK 162.11 1.1647e-05 131161000.0 299000.0 299030.0 303690.0 323100.0 312360.0 202763.0 259950.0 276740.0 220270.0 265500.0 True False 282382.77699183486 321964.6394670034 284150.9160326708 279093.22262141097 273118.5442661696 230691.7627507468 272038.1900811532 277545.2675832265 264330.1548580265 257834.3251481556 1.0952101774252647 1.2487268298431464 1.1020678331692 1.0824517738708361 1.0592792255617303 0.8947286697307961 1.0550891155583564 1.0764480928741536 1.0251938127560722 1.0 17.97608481503537 -5.846179634537911 1.710975296524881 1.0183949321406902 1.1701995213968717 0.5016588620547787 0.059649855727913065 0.30015715215993927 1.7920588753405131 0.01955703732230796 0.0378431689929942 1.4250180502919042e-06 5.846179634537911 0.15180458925618145 VQEKPDSPGGS(ph)TQIQR ddPTM_A459_Selumetinib_30min_R1 2 VQEKPDSPGGSTQIQR 16 1 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 VQEKPDS(0.05)PGGS(0.94)T(0.011)QIQR;VQEKPDS(0.371)PGGS(0.622)T(0.007)QIQR 180.93 4.7076e-06 52193000.0 4995.6 6667.2 7587.3 7128.8 5957.2 5942.2 5138.9 5554.299999999999 3441.6 4622.4 True False 5111.987760254522 5886.601124502809 6556.986334055643 5883.888904149389 5418.372311829086 5882.426863085917 4751.268635647874 5406.981921090916 5840.143835481325 5215.730065988859 0.9801097249240662 1.1286245741298269 1.2571559975492124 1.1281045663228457 1.0388521344617954 1.127824252532643 0.9109498719326599 1.0366682808892254 1.1197174243284163 1.0 12.348653491168122 -6.631048078996887 1.7190387630211001 1.0268707818323646 1.1296372782221074 0.18462368079205316 0.0846762944102234 0.5941083003104107 3.6088951683610997 0.03543148462329949 0.03568779359773978 2.3385783297188862e-07 6.631048078996887 0.10276649638974278 VQEKPDSPGGS(ph)TQIQR ddPTM_A459_Selumetinib_30min_R2 3 VQEKPDSPGGSTQIQR 16 1 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 VQEKPDS(0.116)PGGS(0.724)T(0.16)QIQR;VQEKPDS(0.073)PGGS(0.464)T(0.464)QIQR;VQEKPDS(0.001)PGGS(0.499)T(0.499)QIQR 79.462 0.013551 209743000.0 306544.0 247765.0 271647.0 287746.0 273170.0 212991.0 282715.0 280293.0 169523.0 258839.0 True False 289507.51167286007 266767.77880995907 254169.52776689024 248554.4984104635 238851.94242921492 242328.57691020696 295861.80768914486 281108.606224996 203432.3368683764 251365.6455255121 1.1517385801373434 1.0612738198660634 1.0111545960686723 0.9888165023141029 0.9502171306260421 0.964048115658717 1.1770176750709422 1.1183254801478635 0.8093084337084928 1.0 17.939427962633005 -4.8255626997018055 2.1142276998069423 1.009032574986042 1.1828468673293449 0.19651888199330458 0.09277380900897006 1.128257996546767 6.22120795675479 0.02561472420189863 0.3672793428385885 1.4942982928581701e-05 4.8255626997018055 0.1738142923433028 VQGEAVSNIQENTQTPTVQEES(ph)EEEEVDETGVEVK ddPTM_A459_Selumetinib_30min_R1 3 VQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVK 35 0 E9PAV3;F8VZJ2;F8W0W4;H0YHX9;Q13765;E9PAV3-2 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alpha 1 VQGEAVSNIQENT(0.002)QT(0.031)PT(0.138)VQEES(0.829)EEEEVDETGVEVK;VQGEAVSNIQENT(0.004)QT(0.157)PT(0.157)VQEES(0.681)EEEEVDETGVEVK;VQGEAVSNIQENTQT(0.005)PT(0.161)VQEES(0.834)EEEEVDETGVEVK 132.13 7.366300000000001e-26 31040700.0 5582.5199999999995 6867.96 6040.860000000001 6414.46 5624.030000000001 5621.83 6836.14 6083.4400000000005 3475.67 5799.51 True False 5712.581854307007 6063.85605037202 5220.544392068769 5294.294975326856 5115.337479503144 5565.27949441323 6320.484455992112 5922.087409401963 5897.95813710698 6543.933600511217 0.8729584074417772 0.926637771798037 0.7977685457659498 0.8090386147734233 0.7816915316963989 0.8504486497201723 0.9658540018649259 0.9049736398516215 0.901286366451858 1.0 12.675942394387473 -7.177124345465384 5.98343146489441 0.9348453983078552 0.8369360870611315 0.5354301877758196 0.04692432820654033 0.2125497551216574 12.052243688037159 0.019455821704341087 0.014979412424579758 6.650827051086876e-08 7.177124345465384 -0.09790931124672364 VQGEAVSNIQENTQTPTVQEES(ph)EEEEVDETGVEVK ddPTM_A459_Selumetinib_30min_R2 1 VQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVK 35 0 E9PAV3;F8VZJ2;F8W0W4;H0YHX9;Q13765;E9PAV3-2 E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Nascent polypeptide-associated complex subunit alpha 1 VQGEAVSNIQENTQT(0.001)PT(0.162)VQEES(0.837)EEEEVDETGVEVK 132.13 7.366300000000001e-26 3978900.0 55390.0 58656.0 50615.0 57674.0 55326.0 43722.0 50771.0 50256.0 41473.0 53564.0 True False 52311.64554373822 63154.7265912335 47358.4860054452 49818.70170680068 48375.453259284484 49744.30863120078 53131.9521008279 50402.23663967134 49768.758852440005 52017.468144014456 1.0056553579061038 1.2141061232812151 0.9104342770841807 0.9577302295619942 0.9299847721414128 0.9563000739190102 1.0214251865109603 0.968948286758763 0.9567701125831668 1.0 15.66670855997285 -5.274358511764782 24.999916002850693 0.9621131187733363 1.1098807500882366 0.5318157943001748 0.055236232073353896 474.19684000044424 917622.2712856984 0.013609846926701516 0.028624694841665726 5.316691831071435e-06 5.274358511764782 0.14776763131490034 VQGGVPAGS(ph)DEYEDECPHLIALSSLNR ddPTM_A459_Selumetinib_30min_R1 3 VQGGVPAGSDEYEDECPHLIALSSLNR 27 0 Q9BVS4-2;Q9BVS4;H0Y919;H0Y8R4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 VQGGVPAGS(0.913)DEY(0.087)EDECPHLIALSSLNR;VQGGVPAGS(0.999)DEY(0.001)EDECPHLIALSSLNR;VQGGVPAGS(0.999)DEY(0.001)EDECPHLIALSSLNR 118.59 5.4102e-12 44917000.0 5355.1 6046.1 6654.299999999999 6955.3 6931.6 5391.3 6025.6 4987.2 2720.27 4351.4 True False 5479.86341078929 5338.219801244369 5750.68260945349 5740.687422151027 6304.63800387338 5337.06841690874 5571.084140761606 4854.923255291328 4616.09950934007 4909.944576225319 1.1160743926364471 1.0872260813478063 1.1712316748541622 1.1691959721802743 1.284054820985429 1.086991580872749 1.1346531624282732 0.9887939018292768 0.9401530786501968 1.0 12.261491024058232 -7.754167287297945 2.922065803474398 0.9649663480046446 1.1549783717538402 0.6808216667265514 0.0545999482652644 0.15719164765971974 2.7201951106460482 0.03496889638850638 0.01615990145436869 1.7612974758509456e-08 7.754167287297945 0.19001202374919557 VQGGVPAGS(ph)DEYEDECPHLIALSSLNR ddPTM_A459_Selumetinib_30min_R2 1 VQGGVPAGSDEYEDECPHLIALSSLNR 27 0 Q9BVS4-2;Q9BVS4;H0Y919;H0Y8R4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 VQGGVPAGS(0.931)DEY(0.069)EDECPHLIALSSLNR 80.583 6.642e-05 3864000.0 28321.0 22292.0 27605.0 29295.0 33106.0 22686.0 21696.0 24948.0 25830.0 27817.0 True False 26747.03219794567 24001.724719922546 25828.924354051473 25304.970463306265 28946.92830860486 25810.79057699603 22704.90698980841 25020.59454963627 30996.72175050094 27013.85093275426 0.9901228915687444 0.8884969706714597 0.9561363323706631 0.9367405826847153 1.071558748904872 0.955465055361673 0.8404913111547061 0.9262135417834423 1.147438098613236 1.0 14.721411696018816 -8.245386974572154 24.723578884543382 1.0737190552249944 0.9448188385000794 0.37517513292010374 0.06610120569919796 648.7454603202409 999188.8763404632 0.046004049905559084 0.01725998341527558 5.683462848131476e-09 8.245386974572154 -0.12890021672491503 VQGGVPAGSDEY(ph)EDECPHLIALSSLNR ddPTM_A459_Selumetinib_30min_R2 1 VQGGVPAGSDEYEDECPHLIALSSLNR 27 0 Q9BVS4-2;Q9BVS4;H0Y919;H0Y8R4 Q9BVS4-2 RIOK2 Serine/threonine-protein kinase RIO2 1 VQGGVPAGS(0.39)DEY(0.61)EDECPHLIALSSLNR 75.82 0.00091654 5615900.0 23504.0 24398.0 23418.0 29746.0 38468.0 25643.0 22119.0 22503.0 22898.0 29674.0 True False 22197.74177396686 26269.24814806524 21911.311375590558 25694.543485287875 33635.30593171668 29175.090486022626 23147.577327966996 22568.480004427805 27478.239823576096 28817.234517688838 0.770293962813859 0.9115811627219269 0.7603544109043764 0.8916380740669558 1.1671940939048253 1.012418123193401 0.80325463964137 0.7831591192615874 0.9535349343362276 1.0 14.814644271653004 -5.9962895664477776 24.82351381173184 0.9461975763623857 0.8241884867924774 0.24557512785928415 0.10853767531027714 181.4255327660052 1213742.0102433984 0.03394111004690452 0.05007960402764174 1.0085801896015583e-06 5.9962895664477776 -0.1220090895699083 VQGLLENGDSVTS(ph)PEK ddPTM_A459_Selumetinib_30min_R1 2 VQGLLENGDSVTSPEK 16 0 P41229-4;P41229-3;P41229-2;P41229-5;P41229 P41229-4 KDM5C Lysine-specific demethylase 5C 1 VQGLLENGDSVT(0.276)S(0.724)PEK;VQGLLENGDSVT(0.074)S(0.926)PEK 156.5 8.323e-05 23990400.0 5103.4 6344.799999999999 4746.0 4604.4 4486.5 4770.200000000001 4915.4 5330.2 3278.5 5843.9 True False 5222.299290512233 5601.947866382502 4101.519267911917 3800.3279752925414 4080.6968671559084 4722.216118995061 4544.627420588758 5188.825781070306 5563.37504783401 6594.02148940643 0.7919748667640943 0.8495495314023869 0.6220057478582953 0.5763293282252607 0.618847978234787 0.7161359917588224 0.6892042174703086 0.7868985245811484 0.8436998661244588 1.0 12.686942873309691 -8.43061354163249 1.1858139280164954 0.9966268501262565 0.689400108020227 0.6023855792348471 0.07797081599902747 0.35667045559711524 1.0861669914237366 0.08348883464213985 0.026482732556582417 3.710107200404788e-09 8.43061354163249 -0.3072267421060295 VQGLLENGDSVTS(ph)PEK ddPTM_A459_Selumetinib_30min_R2 4 VQGLLENGDSVTSPEK 16 0 P41229-4;P41229-3;P41229-2;P41229-5;P41229 P41229-4 KDM5C Lysine-specific demethylase 5C 1 VQGLLENGDSVT(0.091)S(0.909)PEK;VQGLLENGDSVT(0.098)S(0.902)PEK;VQGLLENGDSVT(0.005)S(0.995)PEK;VQGLLENGDSVT(0.027)S(0.973)PEK 283.1 8.168299999999997e-63 46380900.0 296793.0 212766.0 245351.0 257866.0 247206.0 220060.0 302584.0 307462.0 225085.0 236017.0 True False 280298.433216514 229084.468049481 229565.3837779703 222744.20595633853 216149.7722303202 250371.26749421438 316654.7555588214 308356.663516926 270108.2894003676 229202.57596418977 1.2229288088817438 0.9994847007534189 1.0015829133344347 0.9718224370704268 0.9430512345729093 1.092358000083437 1.3815497239799563 1.3453455408158377 1.1784696933012169 1.0 17.806263732798115 -7.054968104037516 6.682131360977633 1.2539582790834911 1.021068875659287 0.3690175107962167 0.1204100758100746 0.21817608271330682 21.57989510122868 0.0452195598425789 0.03531570973866833 8.811135824043859e-08 7.054968104037516 -0.23288940342420417 VQGS(ph)DSDEEVVVATTR ddPTM_A459_Selumetinib_30min_R1 1 VQGSDSDEEVVVATTR 16 0 A0A140T936;P26640-2;P26640 A0A140T936 VARS Valine--tRNA ligase 1 VQGS(0.754)DS(0.246)DEEVVVATTR 111.73 0.0027422 0.0 544.23 824.82 706.1 685.85 723.49 658.55 621.16 723.81 380.68 505.46 True False 556.9095001127629 728.2496909515851 610.2154983296685 566.0791724989986 658.0504572425343 651.9255849155583 574.3054011012148 704.6122075337689 645.9861562328659 570.3407145973366 0.9764505423849037 1.2768677955346972 1.0699139702142495 0.9925280766579206 1.1537848173913399 1.1430458465091713 1.006951435172706 1.235423299617017 1.1326320209998253 1.0 9.155680215031959 VQIPVSRPDPEPVS(ph)DNEEDS(ph)YDEEIHDPR ddPTM_A459_Selumetinib_30min_R2 1 VQIPVSRPDPEPVSDNEEDSYDEEIHDPR 29 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 2 VQIPVS(0.005)RPDPEPVS(0.89)DNEEDS(0.572)Y(0.533)DEEIHDPR 57.299 0.011173 7324300.0 9848.5 7348.6 8132.3 10564.0 9521.5 8885.9 7666.1 8166.9 6068.9 10343.0 True False 9301.15979666918 7912.213990526768 7609.076671778763 9125.164976083546 8325.324046709997 10109.852066831036 8022.588840088972 8190.664326896922 7282.849579234033 10044.370715658672 0.9260072193640899 0.7877262015222141 0.7575463796767868 0.9084854825059245 0.8288547169740791 1.0065192089207025 0.7987149287094867 0.8154482305325594 0.7250677802921426 1.0 13.294099560958928 -4.730718098175761 23.520763894429585 0.8437705645375956 0.926008285273549 0.0612413403957901 0.09099635252917473 5613.517460073109 4297307.91890982 0.022283435966855756 2.510832699105935 1.8590107528854286e-05 4.730718098175761 0.08223772073595337 VQIPVSRPDPEPVS(ph)DNEEDSYDEEIHD ddPTM_A459_Selumetinib_30min_R2 1 VQIPVSRPDPEPVSDNEEDSYDEEIHD 27 1 H0YLT6 H0YLT6 TJP1 1 VQIPVSRPDPEPVS(0.383)DNEEDS(0.331)Y(0.286)DEEIHD 49.593 0.018492 3278600.0 15018.0 17326.0 16857.0 21787.0 21623.0 12457.0 14263.0 15535.0 13194.0 16762.0 True False 14183.359681817314 18654.84848812927 15772.438972513884 18819.57301532868 18906.52542792736 14172.838676612864 14926.257761598332 15580.204278042313 15833.168671161804 16278.037507093753 0.871318773877772 1.1460133618686978 0.9689398347706512 1.1561327959299368 1.1614744971369029 0.8706724425740221 0.9169568355579514 0.9571303832696457 0.9726706099713751 1.0 13.990639157197384 -6.76905095770599 24.999990004947954 0.9391486332025717 1.065706880114796 0.29601359282667883 0.09015513101743837 212.5778956413637 698200.4366600326 0.031006256997766476 0.02785812119482741 1.7019587982720984e-07 6.76905095770599 0.12655824691222428 VQIPVSRPDPEPVS(ph)DNEEDSYDEEIHDPR ddPTM_A459_Selumetinib_30min_R1 1 VQIPVSRPDPEPVSDNEEDSYDEEIHDPR 29 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 VQIPVS(0.004)RPDPEPVS(0.631)DNEEDS(0.229)Y(0.137)DEEIHDPR 43.985 0.02286 20533000.0 1278.0 1412.6 1126.7 1247.3 1513.3 1164.9 1410.8 1291.0 744.44 957.5 True False 1307.774913444888 1247.212135300077 973.7003285200925 1029.4824697207853 1376.4222821948156 1153.1821636445738 1304.382220158403 1256.7584862409974 1263.2603082536375 1080.4044518398086 1.2104493934821285 1.1543937394706338 0.9012368718603382 0.9528676672589521 1.2739879772347489 1.06736154380041 1.2073091867931358 1.163229644325213 1.1692475962149598 1.0 10.077355774303188 -6.253947318145693 24.986970511104733 1.1540654115530031 1.0508909822458643 0.14599676967448494 0.10814858261220028 1092.3495355181988 3643123.8906046054 0.03322715041111877 0.042012048700741926 5.572533421436842e-07 6.253947318145693 -0.10317442930713883 VQIPVSRPDPEPVSDNEEDS(ph)YDEEIHDPR ddPTM_A459_Selumetinib_30min_R2 1 VQIPVSRPDPEPVSDNEEDSYDEEIHDPR 29 1 A0A087X0K9;G5E9E7;Q07157-2;H0YKB1;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 VQIPVS(0.001)RPDPEPVS(0.167)DNEEDS(0.433)Y(0.399)DEEIHDPR 50.499 0.010101 6417300.0 19770.0 19455.0 27019.0 20390.0 28135.0 16196.0 15572.0 19688.0 18479.0 20509.0 True False 18671.262545580532 20947.135942315304 25280.6269560629 17612.846825288103 24600.429769908722 18426.851987350237 16296.128855332614 19745.28882047615 22175.316346399803 19916.851881218576 0.9374605312593289 1.0517292625983867 1.269308377992323 0.8843188135518982 1.2351565356122731 0.9251889855508041 0.8182080658389455 0.9913860352145206 1.1133946508539805 1.0 14.281702008166354 VQIS(ph)PDSGGLPER ddPTM_A459_Selumetinib_30min_R1 3 VQISPDSGGLPER 13 0 A0A087WTP3;Q92945;M0QXW7;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 VQIS(0.969)PDS(0.031)GGLPER;VQIS(0.935)PDS(0.065)GGLPER;VQIS(0.952)PDS(0.048)GGLPER 118.16 0.003476 87129000.0 7735.1 8107.9 9113.7 9270.9 10115.5 7514.700000000001 9295.099999999999 7740.700000000001 3902.2799999999997 6042.780000000001 True False 7915.312780115448 7158.6232987395515 7876.1095979706815 7651.911351346449 9200.554811036582 7439.108940801681 8593.963123472058 7535.391490662812 6621.884148745369 6818.429674661684 1.1608703407956158 1.0498932511311334 1.1551207497584812 1.1222395355608212 1.349365653095644 1.0910296498982068 1.2604021062809412 1.10515057721655 0.9711743707430601 1.0 12.73522380082688 -8.111568661793017 4.041341944062284 0.9881947512106376 1.1676535353179045 0.4495756157367622 0.08036191331066662 0.21876423841345163 5.953314475480676 0.06013669080716642 0.02092315782973553 7.734483872111419e-09 8.111568661793017 0.1794587841072669 VQIS(ph)PDSGGLPER ddPTM_A459_Selumetinib_30min_R2 1 VQISPDSGGLPER 13 0 A0A087WTP3;Q92945;M0QXW7;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 VQIS(0.891)PDS(0.109)GGLPER 115.1 0.0040696 5580500.0 17527.0 18296.0 18977.0 25362.0 22516.0 16233.0 22878.0 18166.0 15681.0 16254.0 True False 16552.91950614011 19699.24436908768 17756.040480595348 21907.651848109675 19687.33878440606 18468.948401497688 23941.872331896968 18218.86005245681 18817.638163747783 15784.704787036257 1.0486682981701867 1.247995742388947 1.1248889808302351 1.3879038058476776 1.247241494220087 1.1700534568543823 1.51677669331897 1.1542097428023923 1.1921438137507918 1.0 13.946239658492303 -4.760231826678822 24.6258795780552 1.2413973672021725 1.0486680271497995 0.12627180545609018 0.13577188452280292 47.99649836281625 978305.7436305342 0.03224725825420829 0.19377115724265842 1.7368734370722148e-05 4.760231826678822 -0.19272934005237308 VQISPDS(ph)GGLPER ddPTM_A459_Selumetinib_30min_R1 1 VQISPDSGGLPER 13 0 A0A087WTP3;Q92945;M0QXW7;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 VQIS(0.328)PDS(0.672)GGLPER 126.07 0.0020652 50375000.0 1833.3 1898.4 1865.5 2187.9 2050.7 1469.3 1911.5 1815.3 1076.3 1399.5 True False 1876.0123230191787 1676.1344454577838 1612.1753464580033 1805.8243369695392 1865.214547080491 1454.5201760176606 1767.3140160425216 1767.1523470745792 1826.402490158227 1579.1394572844004 1.1879966106636977 1.0614226867208947 1.020920184738094 1.1435496267536511 1.181158851092256 0.9210840558179428 1.1191627236531214 1.1190603457616715 1.1565808717736923 1.0 10.624922869063784 VQISPDS(ph)GGLPER ddPTM_A459_Selumetinib_30min_R2 1 VQISPDSGGLPER 13 0 A0A087WTP3;Q92945;M0QXW7;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 VQIS(0.234)PDS(0.766)GGLPER 120.54 0.0030147 70813000.0 48599.0 45734.0 64016.0 61646.0 62558.0 46530.0 43445.0 51730.0 43881.0 51645.0 True False 45898.06213721131 49241.65074201227 59897.280255350786 53249.70845471846 54698.9047643842 52939.085142714684 45465.2785846343 51880.52573563751 52658.42613758152 50153.874660175214 0.915144890563296 0.9818114966322374 1.1942702465401411 1.0617267123531235 1.0906217143741035 1.0555333062781502 0.9065157755545475 1.0344270724278326 1.0499373476999785 1.0 15.614073540747567 -7.088695089763442 24.99999992987405 0.9977938867355173 1.0557477473497037 0.09805986883370743 0.07620608005954208 172.50410877374497 48617.45517631225 0.030775520458751537 0.02383861746643492 8.15276473881373e-08 7.088695089763442 0.05795386061418639 VQISSQNPPPS(ph)PMPGR ddPTM_A459_Selumetinib_30min_R2 2 VQISSQNPPPSPMPGR 16 0 Q9C0D5;Q9C0D5-2 Q9C0D5 TANC1 Protein TANC1 1 VQISSQNPPPS(1)PMPGR;VQISSQNPPPS(1)PMPGR 149.12 0.00077095 3826600.0 13159.0 13396.2 12193.400000000001 15197.5 15711.1 11275.2 17199.3 14598.5 9800.8 8994.0 True False 12427.675459650693 14423.645464427886 11408.889919170115 13127.574282850213 13737.331158983921 12828.25645392514 17999.101529766405 14640.97921808823 11761.233857232266 8734.319850781601 1.4228555482243517 1.6513759183134527 1.3062138911880101 1.502987583134533 1.5727991868484894 1.4687184203332315 2.06073304358733 1.6762586518717957 1.346554060094307 1.0 13.092479648238148 -8.561394571582719 3.8900909905360024 1.0006976714270983 1.5832079220060968 0.4734677126636351 0.19084546151099002 0.20863558480065966 9.6800794868456 0.19473268060258045 0.05108829639260747 2.7453987298258193e-09 8.561394571582719 0.5825102505789985 VQMPS(ph)FK ddPTM_A459_Selumetinib_30min_R2 1 VQMPSFK 7 0 Q8IVF2;Q8IVF2-3 Q8IVF2 AHNAK2 Protein AHNAK2 1 VQMPS(1)FK 93.667 0.025408 11453000.0 107290.0 80163.0 122050.0 96276.0 82222.0 35763.0 59428.0 76049.0 61585.0 78394.0 True False 101327.25131589963 86311.24433532887 114197.43587799229 83163.04271463637 71892.53728599373 40689.02862580925 62191.519754348024 76270.2899994104 73903.72082867207 76130.5615279267 1.3309668191364925 1.133726621780763 1.500020932278316 1.0923739566025659 0.9443321557482754 0.5344637923218712 0.8169060953469329 1.0018353794938508 0.9707497139839464 1.0 16.216188098899202 -6.114882156856349 2.9878978834161902 0.8561143563420988 1.3022654657084545 0.6173072080162147 0.1552227709046502 0.18040885238220689 3.086740019490917 0.05022470081848178 0.0688937562160409 7.675697364468786e-07 6.114882156856349 0.4461511093663557 VQMT(ph)SPSSTGSPMFK ddPTM_A459_Selumetinib_30min_R2 2 VQMTSPSSTGSPMFK 15 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 VQMT(0.93)S(0.067)PS(0.001)S(0.002)T(0.001)GSPMFK;VQMT(0.845)S(0.151)PS(0.002)S(0.001)T(0.001)GSPMFK 117.48 0.0049957000000000005 28851000.0 173413.0 165812.0 175972.0 201813.0 194787.0 141117.0 155041.0 172031.0 169778.0 215990.0 True False 163775.3996872409 178529.247230387 164650.15310382663 174325.7212531567 170316.11564212557 160554.58581741815 162250.71370791306 172531.581728735 203738.34399367237 209753.80749058508 0.7807982207645601 0.8511370990888945 0.7849686023516739 0.831096814588128 0.8119810442524162 0.7654430102520295 0.7735292896420761 0.822543265330138 0.9713213144072118 1.0 17.678337473411467 -8.272276491203716 3.4665435220459524 0.9979287062633684 0.801193978456641 0.8965823692441232 0.025043205016476205 0.06883288713502574 1.6673158556458645 0.023177729399139466 0.0066535912172829914 5.3422414023564986e-09 8.272276491203716 -0.1967347278067274 VQMTSPS(ph)STGSPMFK ddPTM_A459_Selumetinib_30min_R1 1 VQMTSPSSTGSPMFK 15 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 VQMTSPS(0.309)S(0.309)T(0.309)GS(0.072)PMFK 125.39 0.0012338 9439400.0 1698.5 2038.8 1903.1 2217.8 2022.4 1615.6 1915.7 1592.2 870.58 1507.0 True False 1738.071745294319 1800.0963481875942 1644.6694729800195 1830.5028632620524 1839.4742770837202 1599.348530847432 1771.1972066610824 1549.9696838055127 1477.31067535255 1700.4381294230725 1.0221317172439641 1.0586073771459912 0.9672033604292476 1.0764889539868814 1.0817648965021855 0.9405508516737752 1.0416122621656438 0.9115119550579526 0.8687823742542015 1.0 10.731690799088693 -7.764313007946532 24.99785034182508 0.917610341226841 1.0265266856007171 0.43575032910974953 0.051907679153806445 65.09786245445655 566267.1188431848 0.026389370829461717 0.013545348897109543 1.7206280241734794e-08 7.764313007946532 0.1089163443738761 VQMTSPSSTGS(ph)PMFK ddPTM_A459_Selumetinib_30min_R2 2 VQMTSPSSTGSPMFK 15 0 P49790-3;P49790;P49790-2 P49790-3 NUP153 Nuclear pore complex protein Nup153 1 VQMTSPSSTGS(1)PMFK;VQMT(0.001)SPS(0.002)S(0.002)T(0.002)GS(0.993)PMFK 145.69 0.00035804 13263900.0 58315.0 50508.0 59052.0 66792.0 64743.0 52613.0 49593.0 54631.0 48053.0 70845.0 True False 55074.085753440966 54381.801191182814 55252.65861095626 57694.8143773733 56609.40553023637 59859.963176738594 51899.17276666519 54789.96716535108 57664.94271300123 68799.52077258441 0.8005010083643951 0.7904386626607602 0.8030965621634625 0.8385932595095028 0.8228168582359425 0.8700636647543613 0.7543536958377514 0.7963713489583502 0.8381590753169875 1.0 16.07011089532822 -8.712656373332145 4.017386435641098 0.9999952816926876 0.8104926555349145 0.7934135878212645 0.028992650039706996 0.8494063037764384 17.594853585330608 0.02913273679582686 0.007627186904602181 1.937954724708669e-09 8.712656373332145 -0.18950262615777314 VQNHLPASGPTQPPVVS(ph)STNEGSPSPPEPTGK ddPTM_A459_Selumetinib_30min_R1 1 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGK 32 0 O43294-2;O43294;H3BQC4 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 VQNHLPASGPTQPPVVS(0.232)S(0.232)T(0.232)NEGS(0.232)PS(0.072)PPEPT(0.002)GK 61.112 0.00054263 7067100.0 1028.9 985.14 1235.7 1005.9 1295.8 1257.3 1087.7 1119.3 656.3 865.08 True False 1052.8713681091112 869.7993508208394 1067.8987272142344 830.2384480815666 1178.5951187920705 1244.6527035370607 1005.6539132877058 1089.6125280012 1113.6931657445357 976.1214445927748 1.0786274330325316 0.8910769819053699 1.094022401751196 0.8505483131025068 1.2074267247389132 1.275100255641155 1.030254912294496 1.1162673804956433 1.140937095393037 1.0 9.930916842288322 -6.275317946774532 24.98337420380151 1.1365790816295975 0.9805660476898691 0.34365183046956416 0.10099457400188738 860.9882333398899 1549896.3806359447 0.0304819331470103 0.03473904784467417 5.304959262272742e-07 6.275317946774532 -0.15601303393972843 VQNHLPASGPTQPPVVSS(ph)TNEGSPSPPEPTGK ddPTM_A459_Selumetinib_30min_R2 1 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGK 32 0 O43294-2;O43294;H3BQC4 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 VQNHLPASGPTQPPVVS(0.102)S(0.264)T(0.264)NEGS(0.264)PS(0.102)PPEPT(0.003)GK 72.578 4.1393e-05 29152000.0 23359.0 22765.0 28201.0 27222.0 32344.0 24495.0 23467.0 24681.0 22468.0 29699.0 True False 22060.80029348585 24511.002298987813 26386.578362927186 23514.31663943071 28280.65756097128 27868.963906529025 24558.26199897834 24752.81762384048 26962.227808372245 28841.512702731026 0.7648974768024873 0.8498514814955197 0.914881914651745 0.8152941519327495 0.9805538930103816 0.9662795496815286 0.8514900814010667 0.8582357617288436 0.934840973366115 1.0 14.815859213736232 -3.568794298226985 0.7467096976650787 0.9158607901946769 1.0731830826161008e-09 0.426588651515696 0.055620726872770566 15.115463372428183 1.5945762565373813 0.021536807677444977 17.558303310092672 0.00026990175081478314 3.568794298226985 -0.9158607891214938 VQNHLPASGPTQPPVVSSTNEGS(ph)PSPPEPTGK ddPTM_A459_Selumetinib_30min_R1 1 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGK 32 0 O43294-2;O43294;H3BQC4 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 VQNHLPASGPTQPPVVS(0.041)S(0.103)T(0.103)NEGS(0.682)PS(0.07)PPEPTGK 96.913 6.6835e-09 12367000.0 1188.7 1221.7 1242.6 1446.9 1301.2 1425.5 1335.8 1180.3 659.95 904.54 True False 1216.3943971924389 1078.662796047079 1073.861745113222 1194.2260766768256 1183.506689745519 1411.1607642504416 1235.0395305412494 1148.9946098452742 1119.886949159083 1020.6465199657242 1.191788119978392 1.056842672704457 1.0521387415785093 1.1700682394105755 1.1595656935030396 1.3826145846240987 1.2100560834545588 1.1257517537843174 1.0972329080166674 1.0 9.995267589477127 -3.701156042652879 15.601186815251811 1.1526448377370082 45.13660545491553 0.0 0.10219564664416729 0.0 0.0 0.02466865194013933 0.0 0.00019899582155777156 3.701156042652879 43.983960617178525 VQNHLPASGPTQPPVVSSTNEGS(ph)PSPPEPTGK ddPTM_A459_Selumetinib_30min_R2 1 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGK 32 0 O43294-2;O43294;H3BQC4 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 VQNHLPASGPTQPPVVS(0.075)S(0.123)T(0.123)NEGS(0.502)PS(0.171)PPEPT(0.007)GK 62.242 0.00040693 20818000.0 37215.0 36300.0 35185.0 47557.0 50466.0 41652.0 31124.0 34728.0 34143.0 38193.0 True False 35146.739283448616 39084.093277103384 32921.23540653146 41079.6545595991 44126.00990823577 47389.18492078982 32571.327671035986 34829.05273047011 40972.55403512787 37090.268852668654 0.9476000139837164 1.0537559981663835 0.8875976482484507 1.1075588241966439 1.1896923714280625 1.2776716477583623 0.8781636984195781 0.939034787502333 1.1046712602133075 1.0 15.17875310495322 -4.759960257877907 22.611603874060062 1.0498174439030945 0.9475996071715975 0.05829127417340707 0.12180964742621335 40.68584633801721 621179.3724030786 0.03254678071952853 0.1974673703477453 1.7379598615155953e-05 4.759960257877907 -0.10221783673149698 VQNHLPASGPTQPPVVSSTNEGSPS(ph)PPEPTGK ddPTM_A459_Selumetinib_30min_R1 1 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGK 32 0 O43294-2;O43294;H3BQC4 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 VQNHLPASGPTQPPVVS(0.016)S(0.016)T(0.03)NEGS(0.178)PS(0.76)PPEPT(0.001)GK 101.75 2.4285e-09 10492000.0 1494.1 1525.2 1708.5 1821.3 1665.4 1351.1 1319.3 1407.6 906.29 1077.0 True False 1528.9096229874854 1346.6288749537568 1476.4950841187333 1503.2441450352499 1514.7648640502516 1337.5091607006468 1219.784138825476 1370.2658754708189 1537.9079371973423 1215.2434408683803 1.2581097511581447 1.108114497611682 1.2149788548240752 1.2369901325787631 1.2464703063674563 1.1006100635646292 1.0037364513186355 1.127564921882371 1.2655142874899161 1.0 10.247029632035076 -6.774268659566658 24.430365193295984 1.1014736173090613 1.208559669205053 0.3398687851024743 0.07891226466442365 228.59202179619817 435296.47313451837 0.028348871965498037 0.025167781869581032 1.6816334614198425e-07 6.774268659566658 0.10708605189599174 VQNHLPASGPTQPPVVSSTNEGSPS(ph)PPEPTGK ddPTM_A459_Selumetinib_30min_R2 1 VQNHLPASGPTQPPVVSSTNEGSPSPPEPTGK 32 0 O43294-2;O43294;H3BQC4 O43294-2 TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein 1 VQNHLPASGPTQPPVVSS(0.001)T(0.002)NEGS(0.113)PS(0.881)PPEPT(0.004)GK 120.34 6.289e-17 4705700.0 12708.0 14311.0 15981.0 18154.0 16587.0 14861.0 14617.0 13493.0 13743.0 15028.0 True False 12001.740234154644 15408.607682882262 14952.799858797189 15681.393882603243 14503.192770338579 16907.967855273644 15296.719463036012 13532.262396113601 16491.98401150345 14594.102592566813 0.8223691835815563 1.0558105635580703 1.0245782338417349 1.0745020999503059 0.9937707836674702 1.158547964702218 1.048143890041383 0.9272418300667534 1.130044407108888 1.0 13.833097880210904 -4.759876747303794 24.99456626569282 1.045772015663391 0.8223689078652676 0.5288177222343946 0.06328495707201216 30.889871737282 493928.28971540905 0.015139869718083012 0.093107486015452 1.738294086303322e-05 4.759876747303794 -0.22340310779812333 VQNS(ph)PPVGR ddPTM_A459_Selumetinib_30min_R1 2 VQNSPPVGR 9 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y8P9;H0YA73 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 VQNS(1)PPVGR;VQNS(1)PPVGR 121.29 0.0063098 161739000.0 8038.4 9288.3 9309.9 9182.3 8626.1 7833.6 8521.1 8279.3 4582.9 7158.5 True False 8225.679079996384 8200.821517986475 8045.66671562014 7578.783678118468 7845.87077806165 7754.8010963397155 7878.3465666230295 8059.706069043448 7776.8465782273815 8077.363204694799 1.018361917316703 1.0152844820968208 0.996075886614058 0.9382744697816062 0.9713405946016395 0.9600659150541107 0.9753611874285788 0.9978139975628324 0.9627952069441735 1.0 12.979668697397594 -5.528410587075154 24.99618749905251 0.9713802336331124 1.0140374518098052 0.5323763859074868 0.016886825165119888 103.77759629199119 468929.0668407753 0.004611129136403947 0.008022816144177576 2.962029727874031e-06 5.528410587075154 0.04265721817669277 VQNS(ph)PPVGR ddPTM_A459_Selumetinib_30min_R2 1 VQNSPPVGR 9 0 E7EMZ9;E9PBC6;O95359-5;O95359-3;O95359;E9PGB3;D6RAA5;Q4VXL8;O95359-6;O95359-1;H0Y8P9;H0YA73 E7EMZ9 TACC2 Transforming acidic coiled-coil-containing protein 2 1 VQNS(1)PPVGR 115.91 0.008015399999999999 116790000.0 42972.0 45789.0 50419.0 55960.0 52912.0 29867.0 43561.0 39441.0 37368.0 44251.0 True False 40583.78827054559 49300.869065159415 47175.09643205657 48338.15146361558 46264.72152071833 33980.90814436836 45586.67281448397 39555.766780190956 44842.64414915675 42973.35865209436 0.9443941442675133 1.1472426315171593 1.0977754104346098 1.124839970153456 1.0765907755842483 0.7907435958048455 1.0608124252876439 0.9204718462996645 1.0434987060749856 1.0 15.391154917223584 -6.565007261453788 24.999994281710475 0.9608442591586867 1.0868258003817104 0.30592141900322056 0.08626973542367446 160.4472101125978 95211.91076653067 0.026971376730469877 0.026971399039287077 2.722655784578842e-07 6.565007261453788 0.12598154122302374 VQPNEAVY(ph)TK ddPTM_A459_Selumetinib_30min_R1 1 VQPNEAVYTK 10 0 P11413-3;P11413;P11413-2 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 1 VQPNEAVY(0.881)T(0.119)K 126.71 0.029874 0.0 2139.2 1920.4 2025.9 2240.6 2353.9 1889.5 1881.4 2073.1 1386.1 1520.8 True False 2189.039197841394 1695.5586752302618 1750.793907472136 1849.321271271059 2140.9901606147982 1870.493345528733 1739.4844832761705 2018.1146536221631 2352.110463261466 1716.0094938464567 1.275656810577799 0.9880823394686739 1.0202705251634183 1.0776870861744374 1.2476563610471303 1.0900250565257648 1.013679988085086 1.1760509839013384 1.3706861597771123 1.0 10.74484181925206 -7.9875423809426 24.377813018983616 1.2146849085049023 1.0983080774237306 0.07298087599426384 0.12250665426902563 303.6795735636292 594258.2439159822 0.06502399307943839 0.031201275125849148 1.0291000968134718e-08 7.9875423809426 -0.1163768310811717 VQPNEAVY(ph)TK ddPTM_A459_Selumetinib_30min_R2 1 VQPNEAVYTK 10 0 P11413-3;P11413;P11413-2 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 1 VQPNEAVY(0.51)T(0.49)K 132.32 0.034401999999999995 20124000.0 80683.0 70398.0 66227.0 63526.0 73907.0 57302.0 65742.0 71444.0 38194.0 63844.0 True False 76198.96185963959 75797.30023475281 61966.026922505574 54873.649211537595 64622.14192303688 65194.83036423462 68799.13326530159 71651.89021180909 45833.867229525036 62000.65783336679 1.2290024738839418 1.222524129315949 0.9994414428480051 0.8850494676849434 1.0422815528299005 1.0515183651672293 1.1096516661195177 1.1556633867398793 0.7392480794753552 1.0 15.919995902273175 -5.259578839372987 22.746694596716505 1.0068830757412186 1.2257633756476953 0.40223163929992667 0.11069687678927442 46.11669681885457 563766.2891807568 0.02863651634219871 0.06813852862831045 5.500740541022923e-06 5.259578839372987 0.21888029990647673 VQPNEAVYT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 VQPNEAVYTK 10 0 P11413-3;P11413;P11413-2 P11413-3 G6PD Glucose-6-phosphate 1-dehydrogenase 1 VQPNEAVYT(1)K 100.19 0.026748 0.0 19746.0 16503.0 18798.0 17058.0 18507.0 14433.0 14408.0 17092.0 10607.0 16006.0 True False 18648.596369500916 17768.72703449138 17588.557145714884 14734.67097330869 16181.985205320798 16421.014740270806 15078.000548910386 17141.734890267086 12728.69638434237 15543.86519141764 1.1997399707118868 1.1431344016224594 1.1315433406760498 0.9479412483224741 1.04105285307386 1.0564305941959322 0.9700290348140387 1.1027974496157937 0.8188887530606201 1.0 13.92405767345741 -2.3927720987638676 0.3611904610680088 0.9719833524575332 2.597807788043741 0.496688040050994 0.07528005725890533 28.637714050913168 0.7229206762151097 0.059911409155295844 28.824608955258455 0.004047882534618862 2.3927720987638676 1.6258244355862077 VQPQWS(ph)PPAGTQPCR ddPTM_A459_Selumetinib_30min_R1 3 VQPQWSPPAGTQPCR 15 0 P49589-3;B4DKY1;P49589-2;P49589;E9PLP0;C9JLN0;E9PRS8 P49589-3 CARS Cysteine--tRNA ligase, cytoplasmic 1 VQPQWS(1)PPAGTQPCR;VQPQWS(0.997)PPAGT(0.003)QPCR;VQPQWS(0.999)PPAGT(0.001)QPCR 146.67 0.00033901 23869000.0 4232.36 4975.0 4742.3099999999995 4733.02 5187.8 3443.2400000000002 4106.85 3864.0 2377.03 3441.68 True False 4330.9657532610345 4392.524687185246 4098.330349644198 3906.486906788963 4718.564405980483 3408.6041318117823 3797.0669980560942 3761.514167959114 4033.6462985977987 3883.453152802122 1.1152357406799172 1.1310873375711514 1.0553314764945807 1.0059312557871907 1.2150434729915005 0.8777250549172428 0.9777553246178095 0.9686003718739281 1.0386751532427536 1.0 11.923124347086386 -6.768109466018495 24.99999992894799 0.9709139801383114 1.0977909966723907 0.5224841707211647 0.06290953575457343 136.04211646693574 509893.37917558866 0.021847155852430904 0.019706062863041104 1.7056524169001527e-07 6.768109466018495 0.12687701653407923 VQPQWS(ph)PPAGTQPCR ddPTM_A459_Selumetinib_30min_R2 4 VQPQWSPPAGTQPCR 15 0 P49589-3;B4DKY1;P49589-2;P49589;E9PLP0;C9JLN0;E9PRS8 P49589-3 CARS Cysteine--tRNA ligase, cytoplasmic 1 VQPQWS(0.992)PPAGT(0.008)QPCR;VQPQWS(0.999)PPAGT(0.001)QPCR;VQPQWS(0.997)PPAGT(0.003)QPCR;VQPQWS(0.996)PPAGT(0.004)QPCR 207.05 1.9151e-06 72231300.0 65012.9 67902.8 75136.9 77630.2 87242.3 60941.8 66653.6 70356.1 61304.3 68712.8 True False 61399.74328525908 73110.72641808513 70302.67365687113 67056.83284043547 76282.14231794239 69335.97977542006 69753.12447160286 70560.82460292068 73566.87298525864 66728.88292670515 0.9201374366284599 1.0956383984187146 1.053556879321529 1.004914662127501 1.1431652827416656 1.0390699909000205 1.0453213273211772 1.0574255331147162 1.1024742174399103 1.0 16.026023732200137 -4.752880206551041 24.99668196587779 1.0615047678833267 0.9201371709318088 0.5041589505690497 0.04164415353047004 260.65970649987105 761187.9055643968 0.009857273767064582 0.11190779239012652 1.7665250222297788e-05 4.752880206551041 -0.1413675969515179 VQPS(ph)PTVHTK ddPTM_A459_Selumetinib_30min_R2 1 VQPSPTVHTK 10 0 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 VQPS(0.99)PT(0.01)VHTK 83.243 0.026875 7549100.0 67831.0 75626.0 79817.0 104780.0 100140.0 67433.0 90634.0 81030.0 71075.0 99273.0 True False 64061.22456900726 81426.27102408305 74681.66111817866 90508.78324441794 87559.5179370413 76721.28365417324 94848.66058786391 81265.78388476132 85291.98600142678 96406.73054776978 0.6644891306345542 0.8446118913215932 0.7746519428036583 0.9388222453988376 0.9082303428354033 0.7958083758079282 0.98383857692245 0.8429472031985766 0.8847098694957234 1.0 16.556846249956244 -3.8338116310977712 0.7276742239238367 0.9007641144824967 3.5583718176884663e-17 0.5324485408417527 0.06632900944936797 7.905717536074102 1.1409003319572533 0.024648291854328805 8.036993923670275 0.0001466183638847474 3.8338116310977712 -0.9007641144824967 VQQEIDS(ph)DESPVAR ddPTM_A459_Selumetinib_30min_R2 4 VQQEIDSDESPVAR 14 0 A0A087WU78;A0A087WWC4;Q6T4R5-4;Q6T4R5-3;Q6T4R5-2;Q6T4R5 A0A087WU78 NHS Nance-Horan syndrome protein 1 VQQEIDS(1)DESPVAR;VQQEIDS(0.987)DES(0.013)PVAR;VQQEIDS(0.98)DES(0.02)PVAR;VQQEIDS(0.939)DES(0.061)PVAR 220.97 6.984199999999998e-09 25079800.0 96688.0 81734.0 97550.0 106333.0 98398.0 74325.0 101035.0 87184.0 69961.0 86924.0 True False 91314.46803273099 88002.7349837677 91273.7392044092 91850.2619653436 86036.36355071883 84562.5940948263 105733.32769705435 87437.69100591175 83955.15487366628 84414.278264325 1.0817419743470358 1.042510068121488 1.0812594869152976 1.0880891699119246 1.0192157691772785 1.0017569993317585 1.2525526471478365 1.0358163666591995 0.9945610695240316 1.0 16.36519942396663 -7.99494711146808 24.999966035338115 1.0032498786689017 1.0793778053471836 0.2176792992350648 0.06415940384113497 211.5735629929536 1046793.8626440933 0.035967634605631606 0.01718623276233184 1.0117026522564199e-08 7.99494711146808 0.07612792667828194 VQQSSESSTSS(ph)PSQHEATPGAR ddPTM_A459_Selumetinib_30min_R1 2 VQQSSESSTSSPSQHEATPGAR 22 0 O75152;E9PBY7;E9PQ61;A0A1B0GTU1;A0A494C0C4 O75152 ZC3H11A Zinc finger CCCH domain-containing protein 11A 1 VQQSSESSTS(0.035)S(0.965)PS(0.001)QHEATPGAR;VQQSSESSTS(0.15)S(0.849)PS(0.001)QHEATPGAR 158.91 2.9838000000000004e-09 11652100.0 665.87 883.24 808.96 950.51 1329.38 698.21 1509.1799999999998 797.27 178.44 474.01 True False 681.3834754425253 779.8298501928635 699.1076752992049 784.5212717824929 1209.137813721102 691.1866413239574 1395.3413375522111 776.1238097020602 302.799647258045 534.8538007483947 1.2739621079425794 1.4580243219767455 1.3071005091877026 1.46679573125357 2.260688457348933 1.292290791159778 2.6088275629709994 1.4510952499843286 0.566135356679437 1.0 9.06300078267231 -6.006674240122565 24.5114352956319 1.6189458714168379 1.3624316734170105 0.006187957527155397 0.5511902585010094 938.0777968467299 3445168.907691407 0.15897720168524215 0.22616289851131327 9.847494793803818e-07 6.006674240122565 -0.25651419799982733 VQRPEDASGGSS(ph)PSGTSK ddPTM_A459_Selumetinib_30min_R1 1 VQRPEDASGGSSPSGTSK 18 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314;H0YJL6 Q9UI08-4 EVL Ena/VASP-like protein 1 VQRPEDAS(0.004)GGS(0.043)S(0.952)PS(0.001)GTSK 161.1 5.3112e-05 2727700.0 1440.7 1561.7 1569.1 1512.6 1415.0 1290.0 1374.9 1509.9 797.48 1399.9 True False 1474.2655068857982 1378.8554379853674 1356.0248384493448 1248.4528050185684 1287.01349983854 1277.0237712262851 1271.1901860616595 1469.8525471535872 1353.265314365309 1579.59080118073 0.9333211524046594 0.8729193896005758 0.8584658997986873 0.7903646970375878 0.8147765224237244 0.8084522714817794 0.8047591725093968 0.9305274163757383 0.856718913122155 1.0 10.6253351559969 -8.882458842706901 0.9566622015282649 0.9989446010753681 0.8421714088670006 0.47326608196620723 0.047168435044150525 1.1055945136894143 1.7590658178521847 0.048448964699422406 0.01578250993540324 1.3108142599480918e-09 8.882458842706901 -0.1567731922083675 VQRPEDASGGSS(ph)PSGTSK ddPTM_A459_Selumetinib_30min_R2 2 VQRPEDASGGSSPSGTSK 18 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314;H0YJL6 Q9UI08-4 EVL Ena/VASP-like protein 1 VQRPEDAS(0.003)GGS(0.224)S(0.771)PS(0.001)GTSK;VQRPEDASGGS(0.117)S(0.752)PS(0.13)GT(0.001)S(0.001)K 148.69 0.00010349 13923600.0 44752.0 47625.0 58287.0 56139.0 61089.0 43772.0 44651.0 55285.0 42587.0 51357.0 True False 42264.86299645017 51277.6843614889 54536.877878087216 48492.77135482338 53414.45367741082 49801.195677345946 46727.359974278 55445.870197075565 51105.589980200624 49874.1899684891 0.8474295627288069 1.028140695495737 1.0934889952607558 0.9723019338351457 1.0709838838717678 0.9985364315452687 0.9369046395299995 1.111714701173226 1.0246901255436835 1.0 15.606005789547414 -4.761397791379478 22.662981094481108 1.0279442357121076 0.8474291845229401 0.5233414348910719 0.05119240070147551 0.2470133410553353 128608.93396950833 0.012470651082571713 0.06959928852490584 1.7322166496577523e-05 4.761397791379478 -0.18051505118916744 VQRPEDASGGSSPS(ph)GTSK ddPTM_A459_Selumetinib_30min_R1 1 VQRPEDASGGSSPSGTSK 18 1 Q9UI08-4;Q9UI08-3;Q9UI08;Q9UI08-2;H0YJN0;Q9UI08-5;G3V314;H0YJL6 Q9UI08-4 EVL Ena/VASP-like protein 1 VQRPEDAS(0.057)GGS(0.178)S(0.178)PS(0.565)GT(0.015)S(0.008)K 132.5 0.0030599 0.0 1155.6 1147.1 1569.3 1408.0 1326.3 1037.2 966.56 931.18 896.92 1070.4 True False 1182.5232315938274 1012.7969987276779 1356.1976795478663 1162.1192314333882 1206.3363991772837 1026.7667097022506 893.6516010180793 906.482081501078 1522.007731555065 1207.7962665789369 0.9790750843627833 0.8385495358388619 1.1228695741784944 0.9621815065922268 0.9987912966432756 0.8501158168095274 0.7399026025716513 0.7505256528641818 1.260152704285241 1.0 10.238161403244968 -6.751553442219897 24.846522656694166 0.8932824098917261 0.9793334311363229 0.022809897142452407 0.15259301227605526 584.7951923633036 1469774.9778542062 0.05086277850098713 0.05026762675585464 1.7719299864155775e-07 6.751553442219897 0.08605102124459674 VQRPHS(ph)SPPR ddPTM_A459_Selumetinib_30min_R2 2 VQRPHSSPPR 10 1 R4GNF5;E9PP52;E9PMB0;E9PJ55;Q9NUJ3 R4GNF5 TCP11L1 T-complex protein 11-like protein 1 1 VQRPHS(0.5)S(0.5)PPR;VQRPHS(0.5)S(0.5)PPR 76.1 0.032072 4046600.0 4777.0 6032.4 8806.0 10160.5 11847.5 7351.6 5887.0 5887.3 7462.1 9933.1 True False 4511.5134638461395 6495.065682776815 8239.431547247865 8776.622372159869 10359.111132006168 8364.216168819716 6160.757164869194 5904.431068305018 8954.728508494505 9646.305593706775 0.46769340034068996 0.6733215757765522 0.854154107726304 0.9098428706100411 1.073894148529197 0.8670901090129789 0.6386649380969701 0.6120924752951071 0.9283065336781936 1.0 13.235760799877148 -4.9320463205720255 2.322685290183893 0.8484786099164072 0.43499785867195107 0.4538997626110437 0.13600761221045093 0.4452782783750273 3.7172158547828196 0.0402912487758678 0.3333226740094607 1.1693746623064548e-05 4.9320463205720255 -0.41348075124445616 VQRPHSS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 VQRPHSSPPR 10 1 R4GNF5;E9PP52;E9PMB0;E9PJ55;Q9NUJ3 R4GNF5 TCP11L1 T-complex protein 11-like protein 1 1 VQRPHS(0.313)S(0.687)PPR;VQRPHS(0.331)S(0.669)PPR 85.92399999999998 0.019678 26710300.0 4162.8 5568.700000000001 5209.0 5480.6 5321.7 4744.9 4736.4 5071.9 2277.9 3296.6 True False 4259.785140601233 4916.714015181604 4501.64641098887 4523.516093603575 4840.353174622447 4697.170614024498 4379.129534702481 4937.376736146949 3865.4299287665394 3719.7507216032504 1.1451802713180796 1.3217858892066967 1.210201098918966 1.216080439834929 1.301257405909234 1.2627648908688078 1.1772642476469581 1.3273407563232864 1.0391637015666737 1.0 11.860990227297307 -8.35663096540266 5.689789309724869 1.006383214829863 1.2455314873194228 0.7109804893972351 0.0576499790277567 0.11519178651053376 5.338119493081813 0.05136256223968626 0.013383041126286783 4.39915267430473e-09 8.35663096540266 0.23914827248955972 VQS(ph)LPSVPLSCAAYR ddPTM_A459_Selumetinib_30min_R1 2 VQSLPSVPLSCAAYR 15 0 Q96AD5-2;Q96AD5 Q96AD5-2 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 VQS(0.5)LPS(0.499)VPLSCAAYR;VQS(0.611)LPS(0.277)VPLS(0.111)CAAYR 116.58 0.0022404 36168000.0 3574.4 3558.7 3554.4 4465.8 3799.1 2948.8 3087.5 3983.5 1925.21 2610.2 True False 3657.67656542833 3142.045749605253 3071.732002921644 3685.931863448314 3455.4720757855835 2919.1377492961788 2854.6073892394907 3877.844639768408 3266.9407582249555 2945.2445955010635 1.2418922934331242 1.0668199695213119 1.042946316789374 1.2514858253466177 1.1732377273737826 0.9911359327355141 0.9692259154299023 1.3166460421290356 1.1092256185497433 1.0 11.524171736056777 VQS(ph)LPSVPLSCAAYR ddPTM_A459_Selumetinib_30min_R2 2 VQSLPSVPLSCAAYR 15 0 Q96AD5-2;Q96AD5 Q96AD5-2 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 VQS(0.839)LPS(0.161)VPLSCAAYR;VQS(0.952)LPS(0.048)VPLSCAAYR 158.65 0.00014432 24039000.0 58372.0 43672.3 50992.0 52896.0 64689.0 46125.2 54758.0 57665.0 54717.3 40409.6 True False 55127.91792163003 47021.82498142261 47711.23023589176 45691.4735493104 56562.1894930025 52478.5276171232 57304.35550091857 57832.79560304536 65662.2889291012 39242.86985125018 1.4047881342672444 1.1982259493166147 1.215793605736299 1.1643254869611628 1.4413367245413264 1.337275480005481 1.4602488482144738 1.4737147365180008 1.6732285171291916 1.0 15.260142929994755 -6.273090235436516 23.825868746537935 1.4214326144640916 1.2402442202856439 0.15252471164443893 0.16968414194614231 619.278959436811 1266415.8358431582 0.050379303541778865 0.05765641037394264 5.332240934631853e-07 6.273090235436516 -0.1811883941784478 VQS(ph)PEPPAPER ddPTM_A459_Selumetinib_30min_R1 1 VQSPEPPAPER 11 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 VQS(1)PEPPAPER 106.32 0.011186 15169000.0 5218.1 5609.0 5099.4 4617.3 5453.0 4583.0 4790.8 5277.4 2991.3 3869.4 True False 5339.671577344889 4952.295672446645 4406.929488999163 3810.975232455529 4959.777112805342 4536.899181031059 4429.4260989047925 5137.426208588878 5076.01762409208 4366.075181147737 1.2229912119702018 1.1342671545900418 1.0093572158417774 0.8728606527232806 1.1359806936493326 1.0391252996789708 1.0145098091829932 1.1766692041336704 1.1626042643538987 1.0 12.092121257532057 -7.757932994947918 24.986480749192662 1.1272275473084172 1.0568795075839086 0.04761173628926341 0.09897146397619293 234.29961128378108 1669660.5668075646 0.0508026609022703 0.027827023363255703 1.746091527581377e-08 7.757932994947918 -0.07034803972450865 VQS(ph)PEPPAPER ddPTM_A459_Selumetinib_30min_R2 3 VQSPEPPAPER 11 0 A0A0G2JMS7;A0A0G2JNZ2;A0A669KB89;Q14160-2;Q14160;A0A0G2JPP5;Q14160-3;H0YCG0 A0A0G2JMS7 SCRIB Protein scribble homolog 1 VQS(1)PEPPAPER;VQS(1)PEPPAPER;VQS(1)PEPPAPER 120.6 0.0046828 69403000.0 161738.0 95183.0 161012.0 166469.0 153199.0 97608.0 191672.0 145482.0 124571.0 124804.0 True False 152749.2494485131 102483.23003841685 150652.66321661067 143795.63502495777 133952.77200356295 111052.6160027959 200585.12779086287 145905.32853415827 149488.6808045548 121200.58424026529 1.2603012634469355 0.8455671289113295 1.2430027805638317 1.1864269130906213 1.1052155634664105 0.9162712927410293 1.6549848257598119 1.203833541304709 1.2333990115774676 1.0 16.88703712769076 VQS(ph)PSQTR ddPTM_A459_Selumetinib_30min_R2 1 VQSPSQTR 8 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;J3KSK9 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 VQS(0.926)PS(0.065)QT(0.008)R 87.789 0.031979 22659000.0 18124.0 15453.0 12987.0 12911.0 14209.0 12717.0 15019.0 25889.0 14014.0 25802.0 True False 17116.74063612046 16638.19541077351 12151.430559176464 11152.499527282716 12423.9383899283 14468.651316567864 15717.41325958391 25964.33270384534 16817.19158387612 25057.02921835301 0.6831113332295319 0.6640130905297772 0.48495096738268373 0.4450846678629433 0.4958264717522216 0.5774288400466208 0.627265631636479 1.0362095393506494 0.671156641808055 1.0 14.61292775725745 -7.6207689264144145 5.816610752399134 0.8880007725451375 0.5558162702572892 0.6436667399632496 0.11463020404173796 0.13467935955218027 6.653891556303547 0.05558881745421067 0.03154172183716477 2.3945894985949816e-08 7.6207689264144145 -0.33218450228784835 VQSLEGEKLS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 VQSLEGEKLSPK 12 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VQSLEGEKLS(1)PK;VQSLEGEKLS(1)PK 167.92 0.0019454 1127260000.0 5974.4 6360.0 6929.5 6677.400000000001 4629.0 5214.7 4812.3 4786.9 3602.6 5566.0 True False 6113.591895841266 5615.3682433162185 5988.511961018886 5511.317440321955 4210.307767316325 5162.244852568772 4449.3043365950425 4659.935861957421 6113.349076506572 6280.4503174312 0.9734320927391426 0.894102804655732 0.953516333756825 0.8775353934455081 0.6703831022483759 0.821954571990024 0.7084371520695152 0.741974799008267 0.9733934300123601 1.0 12.616652290822476 -6.0074064642992555 21.37270972853089 0.798577915107985 0.9323592385499939 0.20630628228954695 0.10150818953760825 67.5835868844274 195034.8357819598 0.028040625024029688 0.03955119739034432 9.83090582263668e-07 6.0074064642992555 0.13378132344200888 VQSLEGEKLS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 VQSLEGEKLSPK 12 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VQSLEGEKLS(1)PK 125.61 0.013543 41465000.0 43103.0 38805.0 39534.0 33056.0 27449.0 24709.0 38563.0 38498.0 28332.0 26621.0 True False 40707.50781498011 41781.21872225886 36990.425481364655 28553.71577521939 24000.611222826505 28112.44046403044 40356.25591113484 38610.02280631302 33999.19166222193 25852.382560335456 1.5746133927878831 1.616145770114146 1.4308323573285646 1.1044906870219577 0.9283713470823355 1.0874216486012598 1.5610265636813005 1.493480251431496 1.3151279802885898 1.0 14.658009625257328 -5.535682603887156 4.4950179335387626 1.231329881825046 1.5845191858643706 0.39430803028577877 0.19198860465918383 0.23103613157207242 11.684790080913825 0.05986925009440629 0.11509115752254373 2.9128451395108225e-06 5.535682603887156 0.3531893040393246 VQSLPS(ph)VPLSCAAYR ddPTM_A459_Selumetinib_30min_R2 1 VQSLPSVPLSCAAYR 15 0 Q96AD5-2;Q96AD5 Q96AD5-2 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 VQS(0.261)LPS(0.708)VPLS(0.004)CAAY(0.028)R 74.783 0.03992 15888000.0 24039.0 16073.0 20946.0 27992.0 25900.0 14748.0 26942.0 24398.0 17952.0 15661.0 True False 22703.008615741546 17305.747417159295 19598.35716428045 24179.441311106642 22646.210451062216 16779.403130985513 28194.8563845602 24468.994140693674 21542.9016207895 15208.826237835303 1.4927521861787607 1.1378752802177092 1.288617336920138 1.5898295458827032 1.4890176333742826 1.1032674624977339 1.85384828149455 1.6088680190073883 1.4164736504909754 1.0 13.892621194926322 -5.73123525248962 23.56467376313977 1.4682881091790625 1.2895605324253907 0.045014408756347324 0.24558830045276894 267.9086738110245 209013.0916937517 0.06526980107150421 0.11302394467021577 1.8567983756008046e-06 5.73123525248962 -0.1787275767536718 VQSLPSVPLS(ph)CAAYR ddPTM_A459_Selumetinib_30min_R2 1 VQSLPSVPLSCAAYR 15 0 Q96AD5-2;Q96AD5 Q96AD5-2 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 VQS(0.006)LPS(0.03)VPLS(0.889)CAAY(0.075)R 87.083 0.019023 3769600.0 11461.0 8288.4 9538.3 12035.0 12403.0 10806.0 10497.0 11160.0 9549.7 8587.9 True False 10824.043502018125 8924.09362859348 8924.616162515817 10395.812238467008 10844.824255773157 12294.428412898667 10985.131299410901 11192.473752362548 11459.906840912065 8339.945012956121 1.2978554996709153 1.0700422622367274 1.0701049165973406 1.2465084868445886 1.3003472131921376 1.4741618072780154 1.317170710639636 1.342032079944774 1.3740986089367588 1.0 13.025822156365955 -6.019659721242811 3.4250033909875657 1.3265390485815274 1.1389606271755266 0.2062278505684504 0.1293271113585276 0.2938829093351631 7.219350568876426 0.03711450237663598 0.05330010722304338 9.55741135784333e-07 6.019659721242811 -0.18757842140600078 VQSPS(ph)QTR ddPTM_A459_Selumetinib_30min_R1 1 VQSPSQTR 8 0 Q12830-4;Q12830;E7ETD6;E9PE19;A0A2R8Y7Q1;Q12830-2;F5GXF5;J3KSK9 Q12830-4 BPTF Nucleosome-remodeling factor subunit BPTF 1 VQS(0.292)PS(0.708)QT(0.001)R 91.636 0.026587 5950000.0 3104.4 4638.5 3558.9 3614.3 3909.8 3921.3 3608.1 3764.3 2623.3 3192.5 True False 3176.7264798891297 4095.422263619852 3075.6209276383734 2983.1303538137045 3556.159280331254 3881.855282255531 3335.938112102026 3664.4585358303552 4451.5485017486535 3602.288472583386 0.8818634332221972 1.136894586535657 0.8537963994406832 0.8281208949582953 0.987194475788595 1.0776081126761214 0.9260607909365053 1.0172584910176234 1.235755696865726 1.0 11.814698002080956 -8.019865662766907 13.220361398999296 1.1207846694008028 0.9607637736431687 0.2730931449015851 0.1047121024080154 2.4970164794544867 1655.0255524631261 0.06654905853894857 0.026772958321061035 9.552880327993826e-09 8.019865662766907 -0.16002089575763412 VQT(ph)LNEQDWER ddPTM_A459_Selumetinib_30min_R1 1 VQTLNEQDWER 11 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VQT(1)LNEQDWER 132.31 0.0047618 2341500.0 531.22 674.44 445.62 565.94 453.56 588.0 576.1 351.58 476.31 321.49 True False 543.5963924258162 595.4762512613504 385.1072516154464 467.10920300952546 412.5355780825221 582.0852538612834 532.6443131792292 342.2549563072112 808.2632816940119 362.75637307778595 1.4985164500728225 1.64153215616604 1.0616140203079705 1.2876664275981256 1.1372248944446854 1.6046175810024064 1.4683251700308906 0.9434843374449038 2.228116007546188 1.0 8.502857150247173 -6.770552042576422 24.99625865485028 1.446589864532086 1.326137455889217 0.027991887152850836 0.36402129486959406 988.1553819626632 2710518.4264831245 0.123134209959401 0.1100914858281467 1.696086343881754e-07 6.770552042576422 -0.1204524086428691 VQT(ph)PEVDVK ddPTM_A459_Selumetinib_30min_R1 2 VQTPEVDVK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VQT(1)PEVDVK;VQT(1)PEVDVK 126.19 0.011372 17050400.0 9439.9 8759.099999999999 11117.8 11710.0 9300.1 8071.599999999999 9256.4 8068.3 5780.4 7828.1 True False 9659.831303152105 7733.580500004881 9608.063825703988 9665.068323923995 8458.907597066018 7990.407032426423 8558.182295629604 7854.30247446804 9808.916616287852 8832.912887151133 1.0936178615781273 0.8755413529838606 1.0877571134750388 1.094210760074784 0.9576577630886449 0.9046174387216851 0.9688969431679589 0.8892086421336005 1.1104962475693008 1.0 13.108673567931495 -6.311068580899796 24.52778045291401 0.9627676714891147 1.0297629194353695 0.12569768742015486 0.08212468475033338 625.7837253496673 309273.8429407779 0.025156331416815468 0.028524660579289277 4.885752007004527e-07 6.311068580899796 0.06699524794625478 VQT(ph)PEVDVK ddPTM_A459_Selumetinib_30min_R2 2 VQTPEVDVK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VQT(1)PEVDVK;VQT(1)PEVDVK 142.97 0.0048502 31005000.0 253370.0 244430.0 221910.0 263560.0 219950.0 175312.0 280230.0 208616.0 170323.0 191552.0 True False 239288.70972047214 263176.995033674 207632.55219733983 227662.67333363998 192317.91462205144 199459.6366761143 293261.250265211 209223.03802176198 204392.35922224412 186021.39604813434 1.2863504672255792 1.4147673365787186 1.1161756475777305 1.223852084599616 1.0338483567357373 1.0722402955437595 1.5764920406754048 1.1247256631039586 1.098757258919593 1.0 17.505109043067236 -14.522878745280336 0.10470367980229732 0.32987849376498946 1.3495398388229123 0.1734803540914911 0.15811819694461643 364.76441152334706 2.561510417972369 53.30462398713275 2.4471318971115767 3.0000000000000132e-15 14.522878745280336 1.0196613450579228 VQT(ph)TPPPAVQGQK ddPTM_A459_Selumetinib_30min_R1 2 VQTTPPPAVQGQK 13 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 VQT(0.782)T(0.218)PPPAVQGQK;VQT(0.973)T(0.027)PPPAVQGQK 171.49 0.0004686 80911000.0 7374.6 8780.6 9521.3 9165.7 8669.6 7087.400000000001 7668.8 7437.200000000001 4368.9 5988.0 True False 7546.413831526339 7752.5632700098095 8228.359756757218 7565.082556497877 7885.436210742195 7016.107190844326 7090.336241813698 7239.941296569751 7413.7042081689815 6756.618128059295 1.1168921623951387 1.1474029052810448 1.2178222301162744 1.1196551903801018 1.1670685039894553 1.038405169252856 1.0493912941991672 1.0715332965915718 1.0972507351541594 1.0 12.722085603549285 -6.759595439758562 24.9993084570027 1.0556666222733744 1.1550779715552546 0.6805420048499029 0.03502792787419976 30.135039583716946 408559.8965848635 0.011836621860650137 0.0112679297122979 1.7394204041969415e-07 6.759595439758562 0.09941134928188022 VQT(ph)TPPPAVQGQK ddPTM_A459_Selumetinib_30min_R2 2 VQTTPPPAVQGQK 13 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 VQT(0.81)T(0.19)PPPAVQGQK;VQT(0.716)T(0.284)PPPAVQGQK 131.79 0.0034802 20478000.0 72041.0 70100.0 80376.0 82518.0 87627.0 61342.0 71245.0 67910.0 58944.0 78755.0 True False 68037.24962297243 75476.44459297367 75204.69566677202 71278.90604851008 76618.51286468068 69791.30369276594 74558.03366928919 68107.60685689434 70734.44703296652 76481.13851993604 0.8895951464587237 0.9868635071809179 0.9833103575879524 0.93198019051364 1.0017961859277087 0.9125296124425988 0.9748551749115821 0.8905150756763512 0.9248613240051133 1.0 16.22281637939583 -6.795531752447665 24.999966933473164 0.9358533880004181 0.9601551490598421 0.03947743624916922 0.041367065537854214 521.7741220275889 382613.64260093606 0.013971574061002627 0.012322415865676306 1.6012835698789147e-07 6.795531752447665 0.024301761059424054 VQT(ph)TPSKPGGDR ddPTM_A459_Selumetinib_30min_R1 1 VQTTPSKPGGDR 12 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 VQT(0.478)T(0.478)PS(0.044)KPGGDR 182.37 0.0010798 89400000.0 8751.8 9342.5 10266.0 9866.4 9002.1 7715.5 8538.6 7439.2 4829.0 6163.4 True False 8955.699911961625 8248.67575678958 8871.933587101506 8143.418455265898 8187.861644449841 7637.889075113493 7894.526527533698 7241.88825007283 8194.460303794545 6954.532426599979 1.2877501121006352 1.1860863176422485 1.2757052585113808 1.1709512524693422 1.177341788375675 1.0982606171911407 1.1351628036614498 1.0413192154189634 1.178290616986994 1.0 12.763737806115229 -1.5228787454827293 0.11401993253319656 0.9429896796863103 1.9779287000251335 0.6980877928228186 0.04759013504316067 54.225332498616346 0.4306261728292161 0.3702116339655117 8.85721345352058 0.029999999986019276 1.5228787454827293 1.0349390203388231 VQTT(ph)PPPAVQGQK ddPTM_A459_Selumetinib_30min_R1 1 VQTTPPPAVQGQK 13 0 Q2M2I8-2;Q2M2I8;E9PG46 Q2M2I8-2 AAK1 AP2-associated protein kinase 1 1 VQT(0.306)T(0.694)PPPAVQGQK 97.957 0.030278 37353000.0 2772.3 3325.2 3401.3 3638.5 3262.2 2772.1 2995.0 3051.7 1508.0 2480.5 True False 2836.889196043239 2935.8840381564587 2939.422142003542 3003.1042781039664 2967.1345859881894 2744.2151908654173 2769.084738711665 2970.7590026813737 2558.9658600377256 2798.89633711608 1.0135742286784033 1.0489434707615959 1.050207577545461 1.0729601658624834 1.0601087816798025 0.9804633185139665 0.9893488022371232 1.06140372663547 0.9142767547705704 1.0 11.450642339383547 -6.75968347019249 24.999104451074526 0.9929518921582068 1.050527443340556 0.4062661240843791 0.036134798491017014 49.88982097522621 710287.2194990821 0.01187814462861657 0.01129452517111633 1.7390678636474487e-07 6.75968347019249 0.05757555118234925 VQTTPS(ph)KPGGDR ddPTM_A459_Selumetinib_30min_R1 1 VQTTPSKPGGDR 12 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 VQT(0.015)T(0.028)PS(0.957)KPGGDR 66.215 0.04178 77075000.0 3254.9 3695.6 4285.4 4680.0 3904.7 3726.2 3509.5 3737.7 2319.3 2878.0 True False 3330.732837067107 3262.9174339621713 3703.466218017223 3862.7258544802976 3551.5205744307746 3688.717811118902 3244.775589485339 3638.5640542393307 3935.6827050301713 3247.4193340939646 1.0256552956060991 1.0047724356708403 1.140433629600994 1.1894755364440806 1.0936439705042449 1.1358920520032132 0.999185893678445 1.1204478633353017 1.2119416373827292 1.0 11.665077974231167 -5.255987328458175 24.672538608536566 1.1147038241763885 1.0152138536576591 0.2533128226922824 0.06584290803346064 488.17878242981874 2209167.974088509 0.016862941120486526 0.04186953943783769 5.546418956766454e-06 5.255987328458175 -0.09948997051872932 VQTTPS(ph)KPGGDR ddPTM_A459_Selumetinib_30min_R2 1 VQTTPSKPGGDR 12 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 VQT(0.011)T(0.035)PS(0.954)KPGGDR 72.209 0.031854 259540000.0 62268.0 64210.0 71289.0 72917.0 64842.0 61838.0 65027.0 65078.0 50325.0 63878.0 True False 58807.39383855378 69134.7005323087 66702.3433535946 62985.57881115895 56695.968265165124 70355.6231905264 68050.88434855593 65267.36620575715 60391.40619798525 62033.676165024146 0.9479914374591036 1.1144704748497278 1.0752602050562132 1.0153449336712292 0.9139546738184681 1.134152085447329 1.0969990585037166 1.052127976941599 0.9735261543637995 1.0 15.920764002248886 VQVQDNEGCPVEALVK ddPTM_A459_Selumetinib_30min_R2 1 VQVQDNEGCPVEALVK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 201.76 7.7069e-06 3689100.0 14009.0 13767.0 14430.0 16289.0 14192.0 12712.0 12660.0 14122.0 11114.0 13851.0 False True 13230.435862470287 14822.88463211797 13501.589510196067 14070.410099907687 12409.07408191023 14462.962611953346 13248.715085314085 14163.092681977048 13337.110551105967 13451.085640780082 0.9835961360887597 1.1019842582206867 1.0037546314672825 1.0460427117681848 0.9225332745105159 1.0752264165284566 0.9849550764250237 1.0529330538970292 0.9915266995751947 1.0 13.715434997339656 VRAS(ph)LSDLSSLDDVEGMSVR ddPTM_A459_Selumetinib_30min_R1 1 VRASLSDLSSLDDVEGMSVR 20 1 H7BYJ1;A0A087WTM5;Q969K3;Q969K3-2 H7BYJ1 RNF34 E3 ubiquitin-protein ligase RNF34 1 VRAS(0.986)LS(0.014)DLSSLDDVEGMSVR 56.304 0.023074 3510600.0 820.96 669.66 1159.8 1099.5 1016.4 1102.5 730.79 736.4 461.43 805.59 True False 840.0867706899176 591.2558958835119 1002.3055303253776 907.4929651711732 924.4667994599948 1091.4098509899072 675.6659219375955 716.8682798356858 783.0130084862124 908.9953236111037 0.9241926210935412 0.6504498763917398 1.102652020632611 0.9983472319373854 1.0170204130285607 1.2006770801131714 0.7433106688089699 0.7886380283980253 0.8614048809135674 1.0 9.828129062169438 -10.758409352657862 9.896346953694716 1.0000000021109472 0.9223874642136229 0.02182458711389834 0.1588380615260699 7.742059526355825e-09 6.098886897891392e-10 0.16201877893100683 0.03929532493733632 1.7441773697902557e-11 10.758409352657862 -0.07761253789732425 VREEEIEVDSR ddPTM_A459_Selumetinib_30min_R1 2 VREEEIEVDSR 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 ; 166.11 0.0017300999999999998 33354000.0 13563.2 14402.5 15715.3 16554.9 14863.5 14152.8 14488.5 13821.3 8113.8 11760.8 False True 13879.196170606965 12716.248604459395 13581.248577963797 13663.897488960654 13519.099049364062 14010.435681714247 13395.620780241725 13454.7142260904 13768.52599149476 13270.413239893085 1.0458752052184612 0.9582405893911594 1.0234231845272375 1.0296512431040723 1.0187398692848075 1.055764837796952 1.0094350897809456 1.013888112062952 1.0375355870685523 1.0 13.695925676396355 -5.473658351389752 24.99902242580956 1.0248441536773665 0.9992513848790429 0.10600023078993648 0.02451102532507842 640.4627213036753 325289.7737386525 0.005966354601233857 0.012419509713781097 3.3600183454375746e-06 5.473658351389752 -0.025592768798323617 VREEEIEVDSR ddPTM_A459_Selumetinib_30min_R2 2 VREEEIEVDSR 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 ; 145.14 0.0019927 25869000.0 107627.0 109048.0 117722.0 123289.0 130582.0 86960.0 96412.0 106537.0 85788.0 127251.0 False True 101645.52220501755 117411.63095541511 110147.89468602247 106496.82551461224 114177.12174210827 98937.9506557161 100895.3490367537 106847.00503185026 102947.99711699453 123576.93299219578 0.8225282805120009 0.9501096047013076 0.8913305421892822 0.8617856337423248 0.9239355515427694 0.8006182728451781 0.8164577853953174 0.8646193301997384 0.8330680704261852 1.0 16.915049947747953 -6.743798174746112 24.99923211124308 0.8515854448445165 0.8917941342675056 0.03072693010819083 0.06041814153705153 595.098878867324 843308.7786943794 0.01882356629817373 0.01878200713525893 1.8038558336654343e-07 6.743798174746112 0.04020868942298916 VREEYPDR ddPTM_A459_Selumetinib_30min_R1 4 VREEYPDR 8 1 A0A0B4J269;Q13509;Q13509-2;G3V2A3 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 ;;; 134.77 0.0076765 130969000.0 16241.400000000001 17470.7 20469.8 21467.800000000003 20158.9 16112.2 16830.9 16880.1 9760.3 14513.100000000002 False True 16619.793019736935 15425.222322091917 17690.113592562862 17718.851730515427 18335.53105434287 15950.125896707104 15561.331662364675 16432.384913707712 16562.51623589273 16375.997754565366 1.0148873533585825 0.9419409158010914 1.0802464593420662 1.0820013532046129 1.1196588647083332 0.9739941428766052 0.9502524301474349 1.0034432808301177 1.0113897476125 1.0 13.999295189204796 VREEYPDR ddPTM_A459_Selumetinib_30min_R2 2 VREEYPDR 8 1 A0A0B4J269;Q13509;Q13509-2;G3V2A3 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 ; 122.28 0.018261000000000003 20613400.0 30202.0 25518.0 28797.0 31521.0 31786.0 27793.0 23225.0 25561.3 22142.8 24971.0 False True 28523.49374818529 27475.148546697634 26944.23237180294 27227.785423242083 27792.758509554573 31621.233470265845 24305.008519464416 25635.67915109899 26571.97872152505 24250.022347550293 1.176225462368149 1.1329947722490712 1.111101341913807 1.122794240475931 1.1460920782352253 1.3039671888574644 1.0022674689171855 1.0571404340865969 1.095750690069336 1.0 14.565698456362004 -7.3129793990751075 24.999982141766186 1.0435513223641246 1.1587507583108005 0.541815083913805 0.056824901691166003 314.239170496177 152423.55642535145 0.02439551981128416 0.01644747216026609 4.8643027915058805e-08 7.3129793990751075 0.11519943594667592 VRELELELDR ddPTM_A459_Selumetinib_30min_R1 1 VRELELELDR 10 1 O94992 O94992 HEXIM1 Protein HEXIM1 0 184.36 0.00049595 3405800.0 1852.1 1678.1 2474.4 2255.1 2185.2 2045.7 1786.8 1629.9 927.71 1305.3 False True 1895.250326440748 1481.6272718724758 2138.3900709062887 1861.28911846977 1987.5490458283946 2025.1221153469858 1652.020237439066 1586.669757338654 1574.2561127424403 1472.8479696986972 1.2867929110351168 1.005960766049448 1.4518742700536447 1.2637347212764511 1.3494597451459913 1.3749702325089725 1.1216502119882898 1.0772800655475947 1.0688517383532046 1.0 10.524392804865192 -7.44020237266739 4.66536241926344 1.0613527423026967 1.2844481063278994 0.49647053949710107 0.11085151047771437 0.20773538113941922 7.991278929154885 0.050133838547838934 0.03244979401621862 3.629089069667095e-08 7.44020237266739 0.2230953640252027 VRGEVAPDAK ddPTM_A459_Selumetinib_30min_R1 1 VRGEVAPDAK 10 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 105.2 0.035659 16818000.0 6767.7 7210.7 8117.0 8170.3 6698.8 6512.6 6599.4 6855.6 3995.1 4970.5 False True 6925.37424234817 6366.467891836512 7014.7559834894755 6743.510480525722 6092.894722769199 6447.089156967683 6101.60194479258 6673.7672178728 6779.392909440801 5608.512091769998 1.2347970600813276 1.1351438291768592 1.25073386108644 1.2023706769610492 1.0863656212331236 1.1495186337260865 1.0879181224813883 1.1899354247030993 1.208768528713519 1.0 12.453402366986351 -14.522878745280336 0.21901772037647196 0.17889368953963727 1.1891642423421773 0.4708180110389326 0.054216206774232056 146.96162856796875 1.4661809178431475 53.50558917454299 0.10949576889333261 3.0000000000000132e-15 14.522878745280336 1.01027055280254 VRGEVAPDAK ddPTM_A459_Selumetinib_30min_R2 1 VRGEVAPDAK 10 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 105.13 0.035779000000000005 9771300.0 142780.0 127520.0 131880.0 140270.0 146770.0 91191.0 100350.0 110400.0 93927.0 127830.0 False True 134844.85919362595 137300.37395857356 123394.98438008704 121164.98402075312 128331.44045955222 103751.73250052218 105016.4738397527 110721.24572229611 112715.02453965538 124139.21575777321 1.0862390129541508 1.1060193438508672 0.9940048648354735 0.9760411589612137 1.0337703494918085 0.8357691956341006 0.8459572843175215 0.8919119155572971 0.9079727453699297 1.0 16.92159941135587 -5.863510421610603 0.8753655994222536 0.8931697470039993 1.1067680190899711 0.5979149874049214 0.057031096763491086 0.48727231154313394 0.7139611197214089 0.02606114491973903 0.07332625813091169 1.3692715300738477e-06 5.863510421610603 0.21359827208597182 VRGGAPDPSPGATATPGAPAQPS(ph)SPDAR ddPTM_A459_Selumetinib_30min_R1 3 VRGGAPDPSPGATATPGAPAQPSSPDAR 28 1 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 VRGGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR;VRGGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR;VRGGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR 200.5 1.3962e-40 75979500.0 7026.8 6549.17 11193.1 11699.900000000001 8862.9 7215.07 6372.93 5826.199999999999 4197.5 4603.78 True False 7190.510768227334 5782.390131773468 9673.138499297278 9656.73209932351 8061.2522598720825 7142.492946559407 5892.214759224622 5671.670249835245 7122.850926729685 5194.720007614702 1.3841960216695208 1.1131283540397419 1.8621096969842201 1.8589514131980451 1.5518165075414 1.3749524394172457 1.1342699415151336 1.0918144272494772 1.3711712885946932 1.0 12.342830275464005 -7.017239856244041 2.874751596272256 1.1580223432206236 1.5625659965845244 0.4260457435783238 0.22090035931797766 0.2989071540571751 4.9879090983635255 0.09843654543622214 0.0784766441390587 9.610813367340949e-08 7.017239856244041 0.40454365336390086 VRGGAPDPSPGATATPGAPAQPS(ph)SPDAR ddPTM_A459_Selumetinib_30min_R2 2 VRGGAPDPSPGATATPGAPAQPSSPDAR 28 1 O95365 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1 VRGGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR;VRGGAPDPSPGATATPGAPAQPS(0.5)S(0.5)PDAR 136.88 1.0926e-12 33417000.0 40054.0 51405.0 39183.0 47833.0 39978.0 25354.0 21743.0 21334.0 16704.0 39293.0 True False 37827.95902886609 55347.59820687327 36662.00843922472 41318.06288347257 34955.60623214539 28846.28335930341 22754.09258293714 21396.078407966175 20045.266748756003 38158.50899452542 0.9913374506926684 1.4504654313095398 0.9607819960807326 1.0828007690080461 0.9160632098376916 0.7559593946252451 0.5963045512653982 0.5607157871665231 0.525315775614605 1.0 15.219717180132157 -6.491030764578038 1.2026260065953618 0.6307062232667644 1.173391337268883 0.5790177382833359 0.1746593306467945 0.2907747334985295 0.879532157937185 0.07487634104143397 0.08738464997705143 3.228265429556415e-07 6.491030764578038 0.5426851140021185 VRGPVS(ph)GSPDSMNASR ddPTM_A459_Selumetinib_30min_R1 2 VRGPVSGSPDSMNASR 16 1 A0A499FJS7;O14920-4;O14920-2;O14920 A0A499FJS7 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta 1 VRGPVS(0.499)GS(0.499)PDS(0.003)MNASR;VRGPVS(0.803)GS(0.195)PDS(0.001)MNASR 166.77 7.5297e-05 5059300.0 1322.43 1034.82 2588.2 2746.8999999999996 1987.45 1499.35 1106.8899999999999 1187.75 973.35 802.73 True False 1353.2400459991566 913.6627933252335 2236.7366559649436 2267.20548069913 1807.6854984127972 1484.267900300878 1023.3963961377478 1156.2470116442641 1651.7038593287277 905.7682147523446 1.494024656594027 1.0087158927022488 2.469436020755611 2.503074676029595 1.9957484364883074 1.6386840210623939 1.129865653783805 1.276537410799302 1.8235392150301244 1.0 9.822998102949729 -7.005639192912144 4.484037289200913 1.332688532650305 1.9069182231919557 0.2699142975737381 0.4533029853046708 0.3162248485008279 16.13941297634355 0.1892288735698521 0.15548873552745374 9.870992162648971e-08 7.005639192912144 0.5742296905416506 VRMADNEVMDAFR ddPTM_A459_Selumetinib_30min_R2 1 VRMADNEVMDAFR 13 1 O75528 O75528 TADA3 Transcriptional adapter 3 0 98.368 0.033809 8547100.0 67536.0 54875.0 64013.0 67690.0 79684.0 60938.0 52764.0 53361.0 44431.0 60023.0 False True 63782.6194880286 59083.73604906465 59894.47327208464 58470.505228236965 69673.38353600167 69331.65635991293 55217.630549882495 53516.27167561087 53318.4415058655 58289.98003151703 1.094229564901922 1.013617366434479 1.0275260557594987 1.003097019361172 1.1952891989039918 1.189426661707994 0.9472919791708054 0.9181041346501569 0.9147102379694855 1.0 15.830960286967816 -7.385879075286407 8.395453470208707 0.9365568136424233 1.0820983014662 0.5268751591911832 0.06576456666397026 0.2699481175507788 17.2370445106737 0.030637656282274942 0.020596858814259895 4.112642173432069e-08 7.385879075286407 0.14554148782377674 VRPAS(ph)TGGLSLLPPPPGGK ddPTM_A459_Selumetinib_30min_R1 2 VRPASTGGLSLLPPPPGGK 19 1 D6RB24;Q9NVZ3-4;Q9NVZ3;Q9NVZ3-2 D6RB24 NECAP2 Adaptin ear-binding coat-associated protein 2 1 VRPAS(0.84)T(0.158)GGLS(0.002)LLPPPPGGK;VRPAS(0.759)T(0.153)GGLS(0.088)LLPPPPGGK 124.21 0.00022383 76135000.0 8611.6 9234.4 9820.5 9746.7 8225.2 8448.9 8086.700000000001 7473.5 4649.2 6395.799999999999 True False 8812.233524743346 8153.232155043905 8486.930040145176 8044.621813218617 7481.232112277004 8363.911736987415 7476.713708360479 7275.278502650734 7889.352835866972 7216.763230367672 1.2210783759209445 1.1297630107546874 1.1760022837430395 1.1147132802372357 1.0366464678786278 1.1589560956901865 1.036020369477961 1.0081082433239368 1.0931982363878985 1.0 12.817136207850576 -1.5228787452803387 0.18322528907613048 0.994471579266734 1.9253890055036935 0.6380878428071465 0.04319190734866372 35.64649304281314 0.4065888497503445 0.09347278193012534 9.283967315630113 0.02999999999999992 1.5228787452803387 0.9309174262369595 VRPAS(ph)TGGLSLLPPPPGGK ddPTM_A459_Selumetinib_30min_R2 2 VRPASTGGLSLLPPPPGGK 19 1 D6RB24;Q9NVZ3-4;Q9NVZ3;Q9NVZ3-2 D6RB24 NECAP2 Adaptin ear-binding coat-associated protein 2 1 VRPAS(0.682)T(0.257)GGLS(0.062)LLPPPPGGK;VRPAS(0.476)T(0.476)GGLS(0.048)LLPPPPGGK 106.47 0.0004513999999999999 34749000.0 181339.0 204607.0 185528.0 216736.0 212814.0 215270.0 211191.0 187808.0 176024.0 234292.0 True False 171260.90433753293 220299.6989848015 173591.3304676135 187216.18290954584 186078.40273870112 244921.48847350501 221011.79996702753 188354.4901867117 211233.7185214933 227527.38119627736 0.7527045907050373 0.9682337915837881 0.7629469893026382 0.8228292433429939 0.8178286136831148 1.076448413310847 0.971363529105848 0.8278321896749076 0.9283881237101381 1.0 17.79568064761215 -6.700762357247641 24.999956699302377 0.9507074523137014 0.8293129281442161 0.4158258444223131 0.08000625626034462 82.18773440817981 33862.123616475394 0.026883494815802118 0.02688348347859374 1.991762918902704e-07 6.700762357247641 -0.12139452416948526 VRQS(ph)PLATR ddPTM_A459_Selumetinib_30min_R1 1 VRQSPLATR 9 1 K7EK59;O75381-2;O75381 K7EK59 PEX14 Peroxisomal membrane protein PEX14 1 VRQS(1)PLATR 87.21600000000002 0.018046 7173700.0 882.09 1048.9 818.06 1153.2 1006.6 701.23 975.19 879.72 559.79 837.27 True False 902.6409807516441 926.0943003796193 706.9719452819265 951.815268245017 915.5532077296639 694.1762628658981 901.6306331700267 856.3869678667163 949.9227445560471 944.7417602004355 0.9554367328487106 0.9802618444464021 0.7483229545520842 1.0074872397331953 0.9691042000042647 0.734778848686251 0.9543672897223657 0.9064773083440559 1.0054840217442198 1.0 9.883776220492235 -8.259953869495678 22.75453383803105 1.0027420554300779 0.9054343794322385 0.15667506294854006 0.08876141176374239 67.63186524732686 1036135.7684758418 0.06728043544185983 0.022286494990860876 5.4959924886611125e-09 8.259953869495678 -0.0973076759978394 VRS(ph)LETENR ddPTM_A459_Selumetinib_30min_R2 1 VRSLETENR 9 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 VRS(1)LETENR 88.338 0.017228 40731000.0 39816.0 45685.0 42238.0 46327.0 37018.0 26531.0 33022.0 34115.0 21399.0 29303.0 True False 37603.1861160766 49188.89259957213 39520.45306525723 40017.18268146744 32367.467894881145 30185.4044255612 34557.58843185164 34214.269001957706 25679.397938016613 28456.94625166259 1.3214062318397795 1.7285372845197078 1.388780535892823 1.4062360144890615 1.137418878632843 1.0607394116927646 1.2143814774163486 1.20231695626718 0.9023947162466985 1.0 14.796493232420149 -6.140748356850144 1.7725377378350289 1.0915390514120946 1.5138580703889761 0.6692093753708941 0.13004282028284977 0.21129225929120488 1.315318490593968 0.043448489831005056 0.06343798110239351 7.231887192944528e-07 6.140748356850144 0.4223190189768815 VRS(ph)PDEALPGGLSGCSSGSGHSPYALER ddPTM_A459_Selumetinib_30min_R1 1 VRSPDEALPGGLSGCSSGSGHSPYALER 28 1 Q5JSZ5-5 Q5JSZ5-5 PRRC2B Protein PRRC2B 1 VRS(1)PDEALPGGLSGCSSGSGHSPYALER 88.194 1.2664e-05 6307400.0 1003.3 1003.9 1110.0 1234.8 1881.6 956.23 1152.1 1036.9 420.99 777.26 True False 1026.6749379180399 886.3629212995515 959.2680967935589 1019.1653600667244 1711.409612223461 946.6111943873736 1065.1961694389681 1009.3980436741213 714.3892821069514 877.0288921535354 1.1706284104244846 1.0106427840969943 1.0937702342257916 1.1620658899436875 1.9513719873254258 1.0793386658710635 1.214550830615614 1.1509290659690297 0.8145561548750988 1.0 9.776480560244094 -8.090117741430767 3.8623440756204075 0.9107588537441204 1.241764388258977 0.21222033117349837 0.2521927865208684 0.39802404346703024 10.537505014685337 0.1989717355827226 0.06956942303107083 8.126101798255376e-09 8.090117741430767 0.3310055345148567 VRS(ph)PDEALPGGLSGCSSGSGHSPYALER ddPTM_A459_Selumetinib_30min_R2 2 VRSPDEALPGGLSGCSSGSGHSPYALER 28 1 Q5JSZ5-5 Q5JSZ5-5 PRRC2B Protein PRRC2B 1 VRS(1)PDEALPGGLSGCSSGSGHSPYALER;VRS(0.999)PDEALPGGLSGCSSGSGHSPYALER 125.16 1.5959e-12 12674100.0 10705.4 11595.599999999999 18609.5 19712.1 29135.0 15711.0 11567.099999999999 11997.0 16962.0 20116.1 True False 10110.436725111671 12484.945234269415 17412.18503049161 17027.277974730812 25474.800829795277 17875.04763974189 12104.993069773813 12031.90928378973 20354.873957878306 19535.29592509536 0.5175471497272606 0.6390968062188938 0.8913192355649773 0.8716160758464525 1.304039668888247 0.9150128929851178 0.6196472843917118 0.6159061695263772 1.0419537045113354 1.0 14.2537954895084 -5.1361419873312375 2.670673008382846 0.8988163551764806 0.5250342145055142 0.3358238965964271 0.18833805778230828 0.3920807645044028 5.134506782655663 0.05547130837622525 0.22307304519012902 7.309000854687462e-06 5.1361419873312375 -0.3737821406709664 VRT(ph)PVMNSEAK ddPTM_A459_Selumetinib_30min_R2 1 VRTPVMNSEAK 11 1 Q15061 Q15061 WDR43 WD repeat-containing protein 43 1 VRT(1)PVMNSEAK 104.82 0.016678 2450500.0 13434.0 11877.0 14773.0 14540.0 13420.0 11561.0 10420.0 12196.0 10388.0 14298.0 True False 12687.392060562916 12787.92770942581 13822.521263626237 12559.626917100968 11734.059623677806 13153.422809691046 10904.550646838297 12231.488340843507 12465.890264971109 13885.17958933459 0.9137362595085401 0.9209767599439913 0.9954873953696298 0.9045347117258895 0.8450779875177782 0.9472994371491157 0.7853373862887768 0.8809024227701522 0.897783869828111 1.0 13.76125821648056 -5.989801960383703 24.868762450840823 0.8832888720761236 0.9426333558649526 0.12253680363584274 0.05752113090529607 337.35560697016155 822660.3993519231 0.015529216119190592 0.02300484243361082 1.0237597234323425e-06 5.989801960383703 0.05934448378882895 VRVS(ph)PQDANPLMANGTLTR ddPTM_A459_Selumetinib_30min_R1 2 VRVSPQDANPLMANGTLTR 19 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6 O60716-5 CTNND1 Catenin delta-1 1 VRVS(1)PQDANPLMANGTLTR;VRVS(0.928)PQDANPLMANGT(0.056)LT(0.016)R 163.53 3.0224e-06 52009000.0 3277.2 3731.5 4107.799999999999 4129.3 4315.2 3478.2 3598.3999999999996 3431.5 2118.02 3558.7999999999997 True False 3353.552383678861 3294.6142452727127 3549.983322530252 3408.1952715610023 3924.8909219104353 3443.212465952918 3326.96979091154 3340.485472917107 3594.1252459397274 4015.606645647533 0.835129702585221 0.8204524337172578 0.8840465802042726 0.8487373321924108 0.9774092106766924 0.8574576072297754 0.8285098826892325 0.8318756710241574 0.8950391716866382 1.0 11.97140223966607 VRVS(ph)PQDANPLMANGTLTR ddPTM_A459_Selumetinib_30min_R2 5 VRVSPQDANPLMANGTLTR 19 1 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6 O60716-5 CTNND1 Catenin delta-1 1 VRVS(1)PQDANPLMANGTLTR;VRVS(1)PQDANPLMANGTLTR;VRVS(1)PQDANPLMANGTLTR;VRVS(0.999)PQDANPLMANGT(0.001)LTR;VRVS(1)PQDANPLMANGTLTR 129.89 0.00071443 90524000.0 166971.0 147200.0 177942.0 196733.0 196819.0 129581.0 163375.0 168198.0 138020.0 169402.0 True False 157691.42025787177 158489.76667740024 166493.40544860048 169937.6260166459 172092.8376358152 147429.6065307996 170972.2612214211 168687.42833332217 165627.85660101162 164510.9241007451 0.9585468024074978 0.9633996498636312 1.0120507580800004 1.0329868788079843 1.046087599206646 0.8961690984150995 1.039276036871078 1.025387397556769 1.006789412352839 1.0 17.327823861574807 -5.2524897242336674 14.135465442323426 1.0077197026648634 0.9609683524105436 0.17734857908773183 0.039941212994741 3.303806953918809 5195.449987466774 0.01042124997272586 0.025852102427590458 5.591267568151675e-06 5.2524897242336674 -0.04675135025431987 VRYDS(ph)SNQVK ddPTM_A459_Selumetinib_30min_R1 3 VRYDSSNQVK 10 1 A0A087WZ12;A0A087WT34;A0A087X1H1;A0A0A0MTS6;K7EIE8;O95983-2;O95983 A0A087WZ12 MBD3 Methyl-CpG-binding domain protein 3 1 VRYDS(0.792)S(0.208)NQVK;VRYDS(0.777)S(0.223)NQVK;VRYDS(0.677)S(0.323)NQVK 128.36 0.01486 29209200.0 6945.0 9186.8 9872.8 9955.2 9002.9 8550.9 9245.5 9194.1 4454.1 6067.9 True False 7106.804987382428 8111.205185172545 8532.12798740851 8216.71120224835 8188.589284591095 8464.885709596007 8548.104491405242 8950.242601354264 7558.28238540719 6846.774071351199 1.037978603254819 1.1846754545490372 1.2461529909551563 1.2000850497797713 1.1959777260439222 1.2363319749391812 1.2484864262095168 1.3072203797120399 1.1039187662162155 1.0 12.74120869207988 -4.771231999123123 4.068994004981713 1.2077258196198353 1.0216821555803173 0.22113753708319772 0.08246383623465992 0.2910292716926783 9.27506334355143 0.019147079087866916 0.16160326163763458 1.6934329307643794e-05 4.771231999123123 -0.186043664039518 VRYDS(ph)SNQVK ddPTM_A459_Selumetinib_30min_R2 1 VRYDSSNQVK 10 1 A0A087WZ12;A0A087WT34;A0A087X1H1;A0A0A0MTS6;K7EIE8;O95983-2;O95983 A0A087WZ12 MBD3 Methyl-CpG-binding domain protein 3 1 VRYDS(0.789)S(0.211)NQVK 110.98 0.04334 8077900.0 38532.0 38985.0 41395.0 48463.0 48426.0 38545.0 35389.0 42981.0 33075.0 43430.0 True False 36390.54569581735 41975.024143467635 38731.69076746824 41862.25579666195 42342.292946067166 43854.223873327675 37034.65862197317 43106.06759411239 39690.924192714585 42176.06305530854 0.8628246227746715 0.9952333409693249 0.9183334802178323 0.992559588640716 1.003941332564413 1.0397894136258863 0.8780966249364461 1.0220505298843154 0.9410770308424706 1.0 15.364136811910388 -4.755430558430812 24.99855941701972 0.9758754708298248 0.8628244384900292 0.3435254448557601 0.04724681869622627 226.02826648849228 940255.6647331604 0.011276815832111584 0.09976171620950001 1.756181676634195e-05 4.755430558430812 -0.11305103233979563 VRYDSS(ph)NQVK ddPTM_A459_Selumetinib_30min_R2 1 VRYDSSNQVK 10 1 A0A087WZ12;A0A087WT34;A0A087X1H1;A0A0A0MTS6;K7EIE8;O95983-2;O95983 A0A087WZ12 MBD3 Methyl-CpG-binding domain protein 3 1 VRYDS(0.092)S(0.908)NQVK 124.21 0.018578 4235400.0 13909.0 15448.0 17282.0 17017.0 16543.0 16053.0 12681.0 14514.0 12783.0 15443.0 True False 13135.993462138564 16632.811926851045 16170.09493521888 14699.255244037646 14464.72044370357 18264.155035375003 13270.69162692479 14556.233337077947 15339.957186862312 14997.120464267316 0.8759010433660821 1.1090670350005514 1.0782133125986642 0.9801385058592165 0.9644998503657911 1.2178441240698066 0.8848826452080599 0.9706018813251622 1.022860169951415 1.0 13.872397900889247 VRYPPS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 VRYPPSPAK 9 1 P30838;A8MYB8;I3L3I9 P30838 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 1 VRY(0.002)PPS(0.998)PAK 67.252 0.045553 15906000.0 76655.0 67035.0 76782.0 81411.0 72886.0 57361.0 61381.0 71898.0 48347.0 62875.0 True False 72394.82197427798 72176.36894850204 71841.92971392076 70322.68135819181 63729.40907089267 65261.95707868592 64235.338124144095 72107.21127664536 58017.75092804751 61059.63538113109 1.1856412427357819 1.1820635432553908 1.1765862875774995 1.1517049015972871 1.0437240359051767 1.0688232360269456 1.0520098543528869 1.1809309182171803 0.950181745532932 1.0 15.897931354036746 -3.9355750696282774 0.19296847084324847 0.9857014751883706 1.4836028354251256 0.5549022695254517 0.055030544371838866 17.318034146834812 0.4596424701567785 0.12413799943922092 2.1770088592771537 0.00011599117032011433 3.9355750696282774 0.497901360236755 VRYS(ph)LDPENPTK ddPTM_A459_Selumetinib_30min_R2 1 VRYSLDPENPTK 12 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;J3KSJ0;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 VRY(0.007)S(0.993)LDPENPTK 84.046 0.018299 2214200.0 31701.0 31549.0 31643.0 32816.0 32637.0 22922.0 28255.0 27584.0 22202.0 27106.0 True False 29939.18532915773 33968.70685397616 29607.123830293436 28346.404189242476 28536.84828151806 26079.297434801316 29568.913486220343 27664.26487322299 26643.020375711258 26323.37935015413 1.1373610101843716 1.2904386781850357 1.124746311499708 1.0768527783677782 1.0840875672504022 0.9907275615297705 1.1232947370812103 1.0509389583013782 1.0121428567854172 1.0 14.684057091219469 -5.5865998627849045 2.7592055824440638 1.0513687210938882 1.2145982091549274 0.614481325297331 0.05212468795293375 0.16371217523037557 2.505165895115166 0.014083533249466595 0.029154052791106107 2.590598663973919e-06 5.5865998627849045 0.1632294880610392 VS(ph)CHDSDDDIMR ddPTM_A459_Selumetinib_30min_R1 1 VSCHDSDDDIMR 12 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 VS(0.516)CHDS(0.484)DDDIMR 111.12 0.0045864 4457200.0 1770.8 2263.8 1402.4 1884.2 2655.9 1824.7 2630.3 1902.0 402.05 988.45 True False 1812.0561946230093 1998.7532435879327 1211.9617828317892 1555.159840814482 2415.6743139372293 1806.3451746950425 2431.8943533333204 1851.55278143329 682.2494854298194 1115.3271858183382 1.6246857582812948 1.7920779382073493 1.0866423756563848 1.3943530298451658 2.165888489631677 1.61956526987163 2.180431342708633 1.6600983146257375 0.6117034481942077 1.0 10.123251277421943 -8.251831590898206 23.717867409708678 0.8058517321805772 1.6936729392395846 0.5524041799090497 0.31850414923460374 227.90299102893383 562609.9875242737 0.23249601898583505 0.08511290019362865 5.599747043105558e-09 8.251831590898206 0.8878212070590075 VS(ph)CHDSDDDIMR ddPTM_A459_Selumetinib_30min_R2 1 VSCHDSDDDIMR 12 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 VS(0.684)CHDS(0.316)DDDIMR 124.07 0.0020789000000000003 38634000.0 28629.0 22871.0 35771.0 63298.0 64429.0 36888.0 27918.0 43593.0 42912.0 43913.0 True False 27037.914790967367 24625.132158144108 33469.53280452 54676.7032048595 56334.85301743199 41968.987164076054 29216.24231846753 43719.84841279035 51495.59906145938 42645.117590323825 0.6340213444997574 0.577443176372705 0.7848385629053638 1.2821327808289509 1.3210153049317506 0.9841451855580957 0.6851016943870896 1.0252017319495066 1.2075379778796467 1.0 15.380092957401725 -5.5585870493280005 5.9186109139254945 1.0634482998037265 0.6217206760220992 0.5566517927494372 0.17101977420959125 0.14259808035476176 13.62213212470145 0.052484584408631 0.09401961088972668 2.763204011234203e-06 5.5585870493280005 -0.4417276237816272 VS(ph)DFGGR ddPTM_A459_Selumetinib_30min_R2 3 VSDFGGR 7 0 I3L4R8;P27694 I3L4R8 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 VS(1)DFGGR;VS(1)DFGGR;VS(1)DFGGR 83.99799999999998 0.038249 15959200.0 137316.0 132492.0 254435.0 406450.0 422770.0 320638.0 219878.0 339036.0 359908.0 282803.0 True False 129684.52643950093 142653.71037107386 238064.92910788168 351090.8088346412 369657.852988246 364802.9740380343 230102.76267999117 340022.53862956876 431899.6566697369 274637.7425795631 0.47220212787006527 0.5194250033924117 0.8668325295417609 1.2783778570890687 1.3459834380962965 1.3283060463998322 0.8378410065518578 1.2380765128487885 1.5726158124264902 1.0 18.06717037847492 -5.484632490763302 2.506939388088574 1.2318782203471232 0.48437099252792126 0.7085598125217349 0.18871485696073265 0.15916707822149487 1.9606894242925113 0.05526241427548144 0.1331161352512843 3.2761781477975727e-06 5.484632490763302 -0.747507227819202 down VS(ph)DSESEGPQK ddPTM_A459_Selumetinib_30min_R2 2 VSDSESEGPQK 11 0 Q96ST2;Q96ST2-3 Q96ST2 IWS1 Protein IWS1 homolog 1 VS(0.913)DS(0.087)ESEGPQK;VS(0.926)DS(0.074)ESEGPQK 175.48 7.5794e-05 48919000.0 186858.0 137599.0 167786.0 182868.0 178869.0 136425.0 172617.0 179095.0 164617.0 120674.0 True False 176473.18041184038 148152.40084948068 156990.83143158376 157961.0629351044 156397.87711085143 155216.30540715338 180644.0325340965 179616.1367992267 197544.99978328327 117189.82807129415 1.5058745568299694 1.264208705548659 1.3396284815442863 1.347907625899122 1.3345687051926085 1.3244861602896565 1.5414651212236532 1.5326939185366377 1.6856838433375283 1.0 16.83848782552831 -7.25232663176761 24.47892124176948 1.4843518815577836 1.347106186828317 0.031405985820309734 0.17706919175842134 1030.0129628766483 2766856.3416869994 0.06389054014920106 0.048732782247134114 5.593367675104849e-08 7.25232663176761 -0.13724569472946668 VS(ph)EGGPAEIAGLQIGDK ddPTM_A459_Selumetinib_30min_R1 2 VSEGGPAEIAGLQIGDK 17 0 O14907 O14907 TAX1BP3 Tax1-binding protein 3 1 VS(1)EGGPAEIAGLQIGDK;VS(1)EGGPAEIAGLQIGDK 266.99 1.9994e-51 18925900.0 4489.9 4997.3 3839.7 4047.8 4032.1 4109.5 4527.9 4563.799999999999 2549.0 4000.2 True False 4594.50593417543 4412.213792818258 3318.289829962365 3340.9277166165302 3667.397266925074 4068.162161127461 4186.356857566798 4442.7531986883505 4325.4668284059435 4513.664635247628 1.0179103467937127 0.977523619801717 0.7351653474760907 0.7401807592276383 0.8125099145129273 0.9012991637346742 0.9274851358860706 0.984289608934274 0.9583048759599837 1.0 12.140083515101692 -7.310505684416304 2.010058189800876 0.977095594993329 0.8516776133060303 0.27656122023264673 0.08558192736542584 0.5082563321995986 4.006605206524832 0.05066549049463804 0.031035593488318195 4.892088619100024e-08 7.310505684416304 -0.12541798168729867 VS(ph)EGGPAEIAGLQIGDK ddPTM_A459_Selumetinib_30min_R2 2 VSEGGPAEIAGLQIGDK 17 0 O14907 O14907 TAX1BP3 Tax1-binding protein 3 1 VS(1)EGGPAEIAGLQIGDK;VS(1)EGGPAEIAGLQIGDK 194.1 8.8729e-08 5727400.0 38364.0 27163.3 34796.0 39651.0 40681.0 29652.0 32064.0 36517.0 31524.0 37713.0 True False 36231.88246326006 29246.637766224292 32557.26324302026 34250.46539820981 35570.289087245656 33736.29384594402 33555.039533610645 36623.2584242852 37829.680854153754 36624.12769985843 0.989289977366481 0.7985620300886332 0.888956687510297 0.9351885641863957 0.97122556416226 0.9211494161012994 0.9162003750260065 0.9999762649480597 1.0329169110640684 1.0 15.160506777908223 -7.374677310003707 0.6070766287060818 1.0212710761131916 0.8924939161861962 0.3823842440439076 0.0512361189514267 0.8191830518080645 0.611937991370791 0.047944532378576564 0.03285073575419786 4.220099492941416e-08 7.374677310003707 -0.12877715992699534 VS(ph)FRDPLVSEGGPR ddPTM_A459_Selumetinib_30min_R1 1 VSFRDPLVSEGGPR 14 1 H0Y413;O43900-2;O43900 H0Y413 PRICKLE3 Prickle-like protein 3 1 VS(1)FRDPLVSEGGPR 86.699 0.012648 3924900.0 1258.7 1622.9 1587.8 1544.8 1222.7 1570.4 1342.6 1748.5 895.23 1237.1 True False 1288.0252609961497 1432.8901135342583 1372.1854811610917 1275.0296794874278 1112.1070008852187 1554.6032018091164 1241.326601066539 1702.1241000715595 1519.1399249877818 1395.8938353744422 0.9227243708334328 1.026503647499734 0.9830156465967981 0.9134145070175819 0.796698841059715 1.1136973044888483 0.8892700645343554 1.2193793374085447 1.0882918790025886 1.0 10.446973506293412 -7.752581595062462 24.99999478475604 1.11537671820951 0.9526655007707895 0.35654395752974366 0.09378065735716538 187.65906518919988 529648.2065994228 0.043888403365115576 0.024856316840306605 1.7677400642817924e-08 7.752581595062462 -0.16271121743872052 VS(ph)FRDPLVSEGGPR ddPTM_A459_Selumetinib_30min_R2 1 VSFRDPLVSEGGPR 14 1 H0Y413;O43900-2;O43900 H0Y413 PRICKLE3 Prickle-like protein 3 1 VS(1)FRDPLVSEGGPR 67.01899999999999 0.037108 1842900.0 4965.4 4769.4 6307.2 7843.2 6305.5 4457.8 4776.8 4820.4 6410.7 5991.7 True False 4689.4429460710935 5135.197643961894 5901.401618760133 6774.942629725335 5513.346718114784 5071.821486120641 4998.930665049635 4834.426565939819 7693.019129923977 5818.704052693812 0.8059256672282691 0.8825328797371155 1.0142123684788602 1.1643387545356987 0.9475214185472004 0.8716410802457987 0.8591140947846184 0.8308424903826627 1.3221189908021593 1.0 12.506482155159512 -5.0533647497145715 3.5212948530014643 0.9888717476212932 0.8151225177693214 0.16920473262929148 0.141505840072441 0.45245396744881256 10.940889221569998 0.037616838160211795 0.14229561959120055 8.843725422955785e-06 5.0533647497145715 -0.17374922985197172 VS(ph)GAQEMVSSAK ddPTM_A459_Selumetinib_30min_R2 1 VSGAQEMVSSAK 12 0 K7EL96;K7ER39;O60664-3;O60664;K7ERZ3;O60664-4 K7EL96;O60664-3 PLIN3 Perilipin-3 1 VS(1)GAQEMVSSAK 154.81 0.0004322 5906400.0 23078.0 12060.0 15068.0 19960.0 21709.0 13519.0 22217.0 25976.0 10241.0 14292.0 True False 21795.417148553726 12984.963220988066 14098.541284797946 17241.413567079475 18981.721339077587 15381.119536736715 23250.134522150318 26051.585859441715 12289.486157447927 13879.352824924461 1.5703482304602592 0.9355597040281117 1.0157924121274493 1.242234690951688 1.367622941682866 1.108201494028986 1.6751598446577323 1.8770029257169996 0.8854509509534579 1.0 13.760652678154402 -6.583166969696543 1.5221683792405885 1.4015116494996966 1.162423333042225 0.006192128357979332 0.3240297288464781 1.036567131107716 4.944220820128773 0.13416806139291806 0.14093089948459803 2.6111572708206686e-07 6.583166969696543 -0.23908831645747175 VS(ph)GRTSPPLLDR ddPTM_A459_Selumetinib_30min_R1 1 VSGRTSPPLLDR 12 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 VS(0.694)GRT(0.229)S(0.076)PPLLDR 69.21600000000001 0.036811 374740000.0 3426.2 2758.0 8135.1 8808.2 6141.2 4389.8 3494.9 3265.9 2399.4 2000.4 True False 3506.023793775329 2435.0920778405866 7030.398102905653 7270.0132203917465 5585.729544316919 4345.642597619496 3231.2768792398656 3179.2777228617156 4071.6065547576404 2257.1708255460608 1.5532824339633853 1.0788248945453576 3.1146947423462468 3.2208520232991074 2.4746596407764594 1.925260839116236 1.431560625659844 1.4085233101896824 1.8038539700567973 1.0 11.140299892311079 -7.05815339733879 3.26287117273835 1.4475859357859537 2.315306671480618 0.3009508318294474 0.6271111969796679 0.3795129670507276 7.99504286569746 0.28399048344951017 0.2221868802745506 8.746747764098064e-08 7.05815339733879 0.8677207356946641 VS(ph)GRTSPPLLDR ddPTM_A459_Selumetinib_30min_R2 1 VSGRTSPPLLDR 12 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 VS(0.934)GRT(0.063)S(0.003)PPLLDR 90.689 0.013234 90864000.0 52693.0 101700.0 85756.0 131200.0 74604.0 40292.0 19956.0 20568.0 13515.0 80364.0 True False 49764.53400679181 109500.06298295905 80238.552324073 113330.33366737596 65231.5785517778 45841.85726564065 20883.993542063814 20627.849474784303 16218.377640651184 78043.68250925191 0.637649741872346 1.4030612019105844 1.0281236064759103 1.4521397507599785 0.8358341950874081 0.5873871630827542 0.26759364589937257 0.26431158566023477 0.20781153732371008 1.0 16.251994233002442 -6.708870670492886 2.461746107320947 0.3831542647624309 1.1421373823996455 0.5176946826258115 0.29991414606851224 0.2006683189577119 2.4888692476264658 0.10649364109842575 0.10174374598700861 1.9549215294762275e-07 6.708870670492886 0.7589831176372146 VS(ph)GSPEQAVEENLSSYSLDR ddPTM_A459_Selumetinib_30min_R2 1 VSGSPEQAVEENLSSYSLDR 20 0 A0A494BZT8;Q9Y6A5;E7EMT0;C9JA91 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 VS(0.899)GS(0.101)PEQAVEENLSSYSLDR 158.15 2.2421e-07 0.0 7060.0 7558.5 8453.4 10990.0 11390.0 8544.8 11811.0 10806.0 9556.8 8647.1 True False 6667.633463419245 8138.212645591897 7909.517447366009 9493.143041192552 9959.08637210806 9721.768638028541 12360.234903052497 10837.443670970402 11468.427039302642 8397.435755136044 0.7940082732209274 0.9691306826151541 0.9418967501511858 1.130481175207128 1.1859675575388449 1.1577068192611664 1.4719058607257247 1.2905658330689818 1.365705838510085 1.0 13.035733137777273 -5.830825227976989 0.8795212155799165 1.294624335272711 0.8232323955555065 0.6171243954025953 0.12269517393889617 0.45733865685625447 0.6672106745760071 0.052210473354701775 0.1538970431664785 1.4763005176099823e-06 5.830825227976989 -0.4713919397172044 VS(ph)GVDGYETEGIR ddPTM_A459_Selumetinib_30min_R2 1 VSGVDGYETEGIR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 VS(0.999)GVDGY(0.001)ETEGIR 81.904 0.034119 3039900.0 2217.7 2090.0 5554.2 4431.6 6522.7 6811.6 5299.7 2995.0 5602.4 4107.9 True False 2094.449112156496 2250.2962795908 5196.848818955718 3828.008435063597 5703.260112322143 7749.836070451647 5546.146551156325 3003.7149541510576 6723.036544134972 3989.2942533940104 0.5250174539956739 0.5640838044664902 1.3026987955411775 0.9595703379881806 1.42964137264879 1.9426584198090286 1.3902575741154657 0.7529439453095138 1.6852696535020322 1.0 11.961917826301136 -5.235043955982926 1.4158366521126087 1.3529091578786419 0.38574333674202566 0.44340829984490593 0.3356487946968262 0.5773449140724751 1.7795059782893525 0.10510404120434964 0.6241679503527396 5.820443046937898e-06 5.235043955982926 -0.9671658211366162 VS(ph)LERLDLDLTADSQPPVFK ddPTM_A459_Selumetinib_30min_R1 2 VSLERLDLDLTADSQPPVFK 20 1 Q13263-2;Q13263;M0R0K9 Q13263-2 TRIM28 Transcription intermediary factor 1-beta 1 VS(0.998)LERLDLDLT(0.002)ADSQPPVFK;VS(0.999)LERLDLDLT(0.001)ADSQPPVFK 118.24 0.00014269 32496000.0 8148.3 8349.4 13341.0 13849.900000000001 10921.8 9338.1 9435.3 9263.8 5653.2 7072.200000000001 True False 8338.139536168213 7371.848366469244 11529.365476867448 11431.274959821947 9933.925118400408 9244.167192316418 8723.58772459639 9018.09393093676 9593.067506608271 7979.985759061617 1.0448815057971623 0.9237921706938128 1.4447852195444533 1.4324931528657483 1.2448549932711357 1.1584190086829753 1.0931833699941609 1.1300889754967705 1.20214093060441 1.0 12.962170456504506 -6.939902639607076 4.372075109409233 1.11789497105431 1.225717581159063 0.10222279574165061 0.1538888357062313 0.6080584102055814 23.702897684235694 0.06303400266622498 0.0544544279912771 1.1484110441059644e-07 6.939902639607076 0.10782261010475302 VS(ph)LPPIPAVSNIK ddPTM_A459_Selumetinib_30min_R2 1 VSLPPIPAVSNIK 13 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 1 VS(1)LPPIPAVSNIK 137.93 0.0010146 2257700.0 22906.0 9283.6 16504.0 20200.0 24092.0 14160.0 19513.0 28759.0 13482.0 12304.0 True False 21632.97621998317 9995.622268521123 15442.150608196533 17448.72515305637 21065.347574787298 16110.411468318074 20420.393164275963 28842.68392869125 16178.776718554149 11948.751550368786 1.8104800429393388 0.8365411420921727 1.2923651933929388 1.4602969255409644 1.762974774894967 1.348292447157029 1.708998055419916 2.413865901145216 1.35401398634444 1.0 13.54457226753096 -5.9743141234885915 3.159373062533366 1.6613283043519005 1.2670736447703546 0.07236008139217587 0.41129186355228237 0.4809903265160717 9.930752681128451 0.12110065288792886 0.18168694287905968 1.0609279146328472e-06 5.9743141234885915 -0.39425465958154593 VS(ph)LSEIGFGK ddPTM_A459_Selumetinib_30min_R2 1 VSLSEIGFGK 10 0 E5RJM2;E5RGN0;Q00536;Q00536-3;Q00536-2;A0A087WZU2;H0YBX5 E5RJM2 CDK16 Cyclin-dependent kinase 16 1 VS(1)LSEIGFGK 85.288 0.036675 2979500.0 12717.0 15637.0 14740.0 15486.0 21016.0 15034.0 13490.0 14906.0 14735.0 15681.0 True False 12010.240050184502 16836.307619120256 13791.644447698554 13376.780085159946 18375.782194576208 17104.797034936008 14117.31172992789 14949.373992178855 17682.411730299307 15228.248785869066 0.788681628404266 1.105597094968883 0.9056618815222144 0.87841880397783 1.206690437815008 1.1232281055723408 0.9270476158117366 0.9816870082954653 1.1611585796199733 1.0 13.894462424250182 -6.2308289439102245 24.988730817506404 1.0615699483466625 0.9318812265891979 0.3036319336426856 0.10829451462448975 1022.437602858632 834663.5043668757 0.032530813942258735 0.04199273812196146 5.877207932433688e-07 6.2308289439102245 -0.1296887217574646 VS(ph)NGSPSLER ddPTM_A459_Selumetinib_30min_R1 1 VSNGSPSLER 10 0 P46527;E7ES52 P46527 CDKN1B Cyclin-dependent kinase inhibitor 1B 1 VS(0.619)NGS(0.381)PSLER 103.43 0.01423 21008000.0 1363.1 1279.9 1276.5 1408.1 1436.8 1173.2 1304.7 1312.1 668.8 1078.6 True False 1394.8575778691115 1130.0487129906323 1103.1583113125926 1162.201768310621 1306.841693687643 1161.3986731803714 1206.2854285800033 1277.2988456985386 1134.9047527806572 1217.0488164536994 1.1460982986151045 0.9285155186161123 0.9064207584762566 0.954934389318175 1.0737791911220018 0.9542745183915594 0.9911561576428306 1.0495050226665508 0.9325055309511759 1.0 10.249171321114066 VS(ph)PAAAQLADTLFSK ddPTM_A459_Selumetinib_30min_R2 1 VSPAAAQLADTLFSK 15 0 O14686;O14686-3 O14686 KMT2D Histone-lysine N-methyltransferase 2D 1 VS(1)PAAAQLADTLFSK 166.77 7.731e-05 34683000.0 8607.8 6810.1 9807.9 6305.2 6157.9 8921.9 12173.0 10531.0 8475.5 7597.4 True False 8129.412935753568 7332.412772077178 9176.870392034101 5446.420882923321 5384.289549675521 10150.810740055578 12739.068620341888 10561.643466499094 10170.836825256312 7378.043321584184 1.1018386015667976 0.9938153589619736 1.2438081469632358 0.738193128656486 0.7297720161013405 1.3758133827108021 1.7266188425695779 1.4314965372460486 1.3785276640355197 1.0 12.849022544777927 -6.8675597891893485 7.125310838365329 1.4373844944881795 0.9677533582420048 0.4710382506354016 0.21991593596279238 0.18733985289942426 11.270831719612417 0.07877097944620196 0.0695256057456174 1.3565637597232693e-07 6.8675597891893485 -0.4696311362461747 VS(ph)PAHS(ph)PPENGLDK ddPTM_A459_Selumetinib_30min_R2 1 VSPAHSPPENGLDK 14 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 2 VS(1)PAHS(1)PPENGLDK 114.06 0.012362 9180200.0 49062.0 33818.0 40211.0 51329.0 42723.0 32448.0 54439.0 44931.0 42170.0 36310.0 True False 46335.33045074716 36411.73185799123 37623.86803842648 44337.901652536144 37355.75479153405 36917.41746638312 56970.52136883201 45061.74177127254 50605.178328247166 35261.63595529018 1.3140436963701236 1.0326160676197587 1.0669915623350965 1.257397748327791 1.0593880226912642 1.046957024716391 1.6156516799466567 1.2779254436296816 1.4351341608883876 1.0 15.105811789256702 -7.224048208096894 24.973071836208995 1.3553385480404252 1.1249352474415222 0.25449130816432297 0.1679149479433174 658.8767251769391 440055.670052751 0.06035343871508052 0.04674846424040043 5.969690174076002e-08 7.224048208096894 -0.23040330059890302 VS(ph)PAHSPPENGLDK ddPTM_A459_Selumetinib_30min_R2 1 VSPAHSPPENGLDK 14 0 H0YKH0;H0YLW9;H0YLI3;H0YNT2;H0YKT5;H0YKN8;H0YL70;Q04726-2;Q04726-7;Q04726-3;Q04726-6;Q04726-5;Q04726-4;Q04726;A0A0D9SES8 H0YKH0 TLE3 Transducin-like enhancer protein 3 1 VS(1)PAHSPPENGLDK 110.57 0.0027829 4570700.0 43288.0 29159.0 35691.0 39896.0 33889.0 31733.0 40539.0 47197.0 36207.0 27573.0 True False 40882.22625559383 31395.40153903738 33394.67991742261 34462.09597556122 29631.560848496043 36103.932706506865 42424.14382650456 47334.33545611604 43449.411708106345 26776.895846742413 1.5267724268557226 1.172480997003125 1.2471453042412792 1.2870086276170718 1.106609258148977 1.3483240519419337 1.5843563073673357 1.7677304989732248 1.6226455806075915 1.0 14.70870110324078 -7.135783520795066 4.255335113291908 1.5563955152852165 1.260067740714503 0.17164055212856733 0.21540755819701438 0.29517657097510935 8.819343006502141 0.08137876236813235 0.06227044029760044 7.315036192258955e-08 7.135783520795066 -0.2963277745707136 VS(ph)PDFTQESR ddPTM_A459_Selumetinib_30min_R2 1 VSPDFTQESR 10 0 E7EPB1;E7EQS8;Q6N021-2;Q6N021-3;Q6N021;D6RE87 E7EPB1 TET2 Methylcytosine dioxygenase TET2 1 VS(0.967)PDFT(0.033)QESR 87.719 0.033258 5293500.0 9642.3 10993.0 13594.0 15840.0 16294.0 10565.0 10429.0 11741.0 13612.0 13546.0 True False 9106.419567185185 11836.12775193381 12719.376840028102 13682.56467447589 14247.002049791814 12020.232850478838 10913.96916467145 11775.164366172818 16334.780351057638 13154.89178326524 0.692245874555179 0.899751054356139 0.9668933085568084 1.0401122943391994 1.0830193272981448 0.9137462358884747 0.8296510031770432 0.8951167793833456 1.2417266991004545 1.0 13.683311759988733 -4.7296040711576754 1.9129837875152154 0.9888023660670936 0.5737818118059818 0.4247144486771264 0.10755633181899273 0.9881835193210149 3.459223291592995 0.030250839581635814 0.7702166883590346 1.8637855007905433e-05 4.7296040711576754 -0.41502055426111184 VS(ph)PENLVDK ddPTM_A459_Selumetinib_30min_R1 4 VSPENLVDK 9 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 VS(1)PENLVDK;VS(1)PENLVDK;VS(1)PENLVDK;VS(1)PENLVDK 147.96 0.0015832 204427700.0 13177.3 14594.0 12595.3 12116.599999999999 12018.2 12076.2 13593.400000000001 13308.5 7787.999999999999 11490.2 True False 13484.305451437642 12885.32769543347 10884.927441030542 10000.663266751277 10931.155931985551 11954.724392312299 12568.038893890875 12955.515347899554 13215.667186985293 12965.07909402587 1.0400480670920877 0.9938487534079797 0.8395573495611119 0.771353818532387 0.8431229653679844 0.92207107304273 0.9693761837274139 0.9992623457167552 1.0193279262812125 1.0 13.66234338699101 -7.338624641356027 2.335624062853281 1.005475105672524 0.8926077735814884 0.3029051835896833 0.07250549914365653 0.4367589161281848 4.6569087529992395 0.04172133413505461 0.025800634045280466 4.585380277231794e-08 7.338624641356027 -0.11286733209103561 VS(ph)PENLVDK ddPTM_A459_Selumetinib_30min_R2 4 VSPENLVDK 9 0 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 VS(1)PENLVDK;VS(1)PENLVDK;VS(1)PENLVDK;VS(1)PENLVDK 155.88 0.00083125 143933000.0 203526.0 169049.0 194574.0 177104.0 180733.0 149362.0 178686.0 162584.0 133098.0 183590.0 True False 192214.83969913126 182014.51472179184 182055.3206761531 152982.12967855931 158027.70476648005 169935.25972676012 186995.25305959178 163057.09252276982 159721.3190688414 178289.27967589424 1.0781065471157425 1.020894330004976 1.0211232049795984 0.8580556831945257 0.8863556185416925 0.9531434533566988 1.0488306049557428 0.9145647613764861 0.8958548677699137 1.0 17.44386043245639 -5.58918852601102 8.947156041232523 0.9364067055619518 1.0424563837092438 0.43692471819797196 0.05428467860660989 0.29217630597393174 36.218069687996596 0.01574860900433764 0.02733476878032612 2.5752030259531355e-06 5.58918852601102 0.10604967814729194 VS(ph)PGLPSPNLENGAPAVGPVQPR ddPTM_A459_Selumetinib_30min_R1 1 VSPGLPSPNLENGAPAVGPVQPR 23 0 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 VS(1)PGLPSPNLENGAPAVGPVQPR 307.25 1.1249999999999995e-123 23133000.0 2915.4 3209.0 2600.5 2661.1 2946.8 2426.2 3013.7 2449.8 1490.9 2418.3 True False 2983.323147619112 2833.288788176372 2247.366383524009 2196.3888400336577 2680.262460299795 2401.794630813346 2786.3741826562086 2384.8233459281137 2529.9484089723114 2728.712361236773 1.0933080342212904 1.0383244597067753 0.8235995905795667 0.8049176861712742 0.9822444088921785 0.8801934073127248 1.0211315132509242 0.8739738859273559 0.9271583347926151 1.0 11.414004610058985 -5.082197449799592 5.728759845153294 0.9111055192835664 1.0810819944076215 0.44792295794139425 0.06843614121683604 0.17421088724635672 9.236906809490891 0.01760199558501996 0.04966761097537226 8.275658295318652e-06 5.082197449799592 0.16997647512405512 VS(ph)PGLPSPNLENGAPAVGPVQPR ddPTM_A459_Selumetinib_30min_R2 1 VSPGLPSPNLENGAPAVGPVQPR 23 0 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 VS(0.582)PGLPS(0.418)PNLENGAPAVGPVQPR 138.28 3.9725e-06 20067000.0 17775.0 18997.0 21529.0 21461.0 20829.0 18009.0 18672.0 18044.0 16688.0 25827.0 True False 16787.136658962758 20454.008815017416 20143.847579002864 18537.974777710035 18212.274806377405 20489.57628057486 19540.284997866096 18096.505052654997 20026.06630167865 25081.307403395196 0.6693086763367975 0.8155080788272069 0.803141848031257 0.7391151696980753 0.7261294043990727 0.8169261654119847 0.7790776088179907 0.7215136261280111 0.7984458696506295 1.0 14.614324932443534 -8.562334654131798 19.091882792118522 1.0000000009656251 0.7628755855005593 0.7215558340422026 0.04467207109624778 351.3882183724785 170029.8572562984 0.04225021136447665 0.010908957667284553 2.739462411906763e-09 8.562334654131798 -0.2371244154650658 VS(ph)PGQAAPAMAR ddPTM_A459_Selumetinib_30min_R1 2 VSPGQAAPAMAR 12 0 Q96HA7-2;Q96HA7 Q96HA7-2 TONSL Tonsoku-like protein 1 VS(1)PGQAAPAMAR;VS(1)PGQAAPAMAR 138.31 0.0012519 13245200.0 1963.05 1547.34 1922.49 1914.84 2057.5 1715.3000000000002 1818.28 1717.6399999999999 1095.26 1959.46 True False 2008.7852455696284 1366.1767134611503 1661.4264174816658 1580.4491399985159 1871.3994882811282 1698.04563936779 1681.1256756943744 1672.0826075189682 1858.5762253746166 2210.9757777566906 0.9085514485408748 0.6179066850055256 0.7514448752429975 0.714819744249789 0.8464133832257065 0.7680073461006742 0.7603546328309779 0.7562645526652958 0.8406135626055447 1.0 11.110467504523724 -8.64952443519809 2.226867604855777 0.9998619564832076 0.7606894168481918 0.4937978046637984 0.07211585192468985 0.40054845587355004 4.137914224957184 0.06612820535425379 0.01811517317598345 2.2411739445486916e-09 8.64952443519809 -0.23917253963501584 VS(ph)PGQAAPAMARPR ddPTM_A459_Selumetinib_30min_R1 1 VSPGQAAPAMARPR 14 1 Q96HA7-2;Q96HA7 Q96HA7-2 TONSL Tonsoku-like protein 1 VS(1)PGQAAPAMARPR 63.374 0.043178 3881700.0 565.58 600.31 758.52 826.63 597.31 489.89 653.48 667.3 302.72 541.41 True False 578.7569135728945 530.0254261234525 655.5171502521173 682.2745882668906 543.2834159636454 484.962151384531 604.1874774802338 649.6010363041191 513.693730205982 610.9052472799908 0.9473759083749332 0.8676066026333059 1.0730258958664336 1.1168255491414854 0.8893088058787735 0.7938418495237816 0.9890035814397284 1.0633417198434918 0.8408730036174419 1.0 9.254804822061125 -3.5976831464772085 12.939986413074863 0.9593489653693783 0.3766809225792217 0.0 0.10293809444608773 0.0 0.0 0.02456500982233629 0.0 0.0002525322530905167 3.5976831464772085 -0.5826680427901566 VS(ph)PGQAAPAMARPR ddPTM_A459_Selumetinib_30min_R2 4 VSPGQAAPAMARPR 14 1 Q96HA7-2;Q96HA7 Q96HA7-2 TONSL Tonsoku-like protein 1 VS(1)PGQAAPAMARPR;VS(1)PGQAAPAMARPR;VS(1)PGQAAPAMARPR;VS(1)PGQAAPAMARPR 122.52 0.0009691 9956800.0 25031.199999999997 29765.4 29667.699999999997 36683.299999999996 31279.5 24941.2 18790.100000000002 18655.5 16026.8 29951.7 True False 23640.06611183283 32048.310469154047 27758.912481749412 31686.971257777855 27349.889567722053 28376.623906328718 19663.8768818768 18709.784416415714 19232.60782620705 29086.916597137577 0.8127388144730072 1.1018118872148828 0.9543435925580763 1.0893891469024306 0.9402814999790503 0.9755803373507538 0.6760385486790274 0.6432371184457871 0.6612116400161755 1.0 14.82808274900965 -7.254383279976983 23.185000545215107 0.7153915778738703 0.9867392164813374 0.46248990255399147 0.12168793519143525 151.04004264221638 496290.4510325572 0.04445639963590583 0.0336102384788975 5.5669423006306266e-08 7.254383279976983 0.27134763860746713 VS(ph)PLTFGR ddPTM_A459_Selumetinib_30min_R1 4 VSPLTFGR 8 0 O95810 O95810 SDPR Serum deprivation-response protein 1 VS(0.993)PLT(0.007)FGR;VS(1)PLTFGR;VS(1)PLTFGR;VS(1)PLTFGR 128.35 0.0043517 46673600.0 7024.1 9619.7 7748.8 7710.5 7967.5 7298.1 8996.7 8185.9 4870.110000000001 8624.300000000001 True False 7187.747863480621 8493.421051922796 6696.555521111642 6364.005919010753 7246.84103177638 7224.6877401446145 8318.071675715273 7968.783340449402 8264.22097123895 9731.31291279589 0.7386205672237005 0.8727929240415889 0.6881451229778268 0.6539719743923351 0.7446930436536853 0.7424165479916626 0.8547738368147305 0.8188805983179409 0.8492400815076215 1.0 13.248418745886285 -8.476017279467623 0.6378926942863041 0.9978253228390976 0.7390595293180778 0.6394870527618655 0.058499284182509347 0.5614288666819108 0.5346428040358279 0.06423844609093632 0.02720143398314848 3.341817435240045e-09 8.476017279467623 -0.2587657935210198 VS(ph)PLTFGR ddPTM_A459_Selumetinib_30min_R2 4 VSPLTFGR 8 0 O95810 O95810 SDPR Serum deprivation-response protein 1 VS(1)PLTFGR;VS(1)PLTFGR;VS(0.99)PLT(0.01)FGR;VS(0.994)PLT(0.006)FGR 139.38 0.0024082 52645400.0 68252.2 49932.0 59083.1 71832.4 69198.9 55081.5 68612.5 74020.0 66151.3 56533.8 True False 64459.01595920438 53761.62384331474 55281.75767081538 62048.70320219828 60505.5155359849 62668.47664492667 71803.11720308954 74235.3859453293 79383.40842175408 54901.52230154737 1.1740843105435645 0.9792373979728336 1.006925770968236 1.1301818346929422 1.1020735491387201 1.141470655416788 1.3078529372775847 1.3521553289103792 1.4459236300541836 1.0 15.744558532176 -7.100734663043791 2.360865646106988 1.3084047613920105 1.0707966742871229 0.36573066265026055 0.11995704422532738 0.27967426410411744 3.060935894086145 0.05102734707988905 0.037738190504464024 7.929856657623329e-08 7.100734663043791 -0.23760808710488757 VS(ph)PPAPGSAPETPEDK ddPTM_A459_Selumetinib_30min_R2 1 VSPPAPGSAPETPEDK 16 0 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 VS(1)PPAPGSAPETPEDK 162.79 2.1369e-05 0.0 10835.0 8498.1 8777.5 9054.5 12089.0 10377.0 14106.0 8180.5 6715.4 9673.6 True False 10232.834075941575 9149.87694430171 8212.765206219405 7821.261480116279 10570.27174296877 11806.337556972918 14761.956950508738 8204.303900645325 8058.66764395331 9394.298032968753 1.0892601065060985 0.9739819741922962 0.8742287265527636 0.8325541144924302 1.1251795190947746 1.2567556953738588 1.5713741355343946 0.8733280413132295 0.8578254187456983 1.0 13.197569648309479 -6.340619301511228 8.21146147483217 1.1384099588097407 0.9401186082971472 0.1409775847678819 0.202246725486529 0.6429140047004483 61.19039150367481 0.06832285143840466 0.07750401148546339 4.5643684891793625e-07 6.340619301511228 -0.1982913505125935 VS(ph)PPASPTLEVELGSAELPLQGAVGPELPPGGGHGR ddPTM_A459_Selumetinib_30min_R1 2 VSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGR 36 0 Q7Z6J0 Q7Z6J0 SH3RF1 E3 ubiquitin-protein ligase SH3RF1 1 VS(0.989)PPAS(0.008)PT(0.003)LEVELGSAELPLQGAVGPELPPGGGHGR;VS(0.986)PPAS(0.012)PT(0.002)LEVELGSAELPLQGAVGPELPPGGGHGR 140.8 6.3605e-35 33880000.0 1194.3600000000001 1488.73 1560.76 1418.0 1347.8600000000001 1268.1200000000001 1141.88 1365.39 815.12 1141.08 True False 1222.1862641799962 1314.4287995081995 1348.8173646410032 1170.3729191566376 1225.946300984011 1255.3638641608359 1055.7470722671376 1329.175421788223 1383.1991059906843 1287.5487330604376 0.9492349553829484 1.020876931301753 1.0475854855100772 0.9089931037986585 0.9521552617818195 0.9750029897329789 0.8199666895385627 1.0323301849933408 1.074288739893278 1.0 10.330411323260128 -7.965130419500278 24.999994262116775 1.04253334064787 0.9563698767161273 0.2777771895313409 0.06046915651717555 224.16099694199627 160713.64865308214 0.034207291570615306 0.016432544670193543 1.0836014574742008e-08 7.965130419500278 -0.08616346393174279 VS(ph)PPASPTLEVELGSAELPLQGAVGPELPPGGGHGR ddPTM_A459_Selumetinib_30min_R2 2 VSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGR 36 0 Q7Z6J0 Q7Z6J0 SH3RF1 E3 ubiquitin-protein ligase SH3RF1 1 VS(0.965)PPAS(0.031)PT(0.004)LEVELGSAELPLQGAVGPELPPGGGHGR;VS(0.903)PPAS(0.074)PT(0.022)LEVELGSAELPLQGAVGPELPPGGGHGR 140.19 7.1953e-35 9917800.0 10525.0 9452.0 12271.7 13212.5 14387.0 12264.7 10682.6 11733.3 5980.2 12031.2 True False 9940.06263491325 10176.938007029785 11482.152182416712 11412.934707166203 12579.576438588108 13954.051097138461 11179.362067170323 11767.441960447626 7176.407100748957 11683.827995188307 0.8507539343275866 0.8710277155073579 0.9827388923514921 0.9768146802457496 1.0766656650344983 1.194304734962299 0.9568235745831131 1.0071563844738003 0.6142171130646892 1.0 13.512225404185271 -12.139820512084448 2.2047578775844814 1.9061044266322988 0.9605011919813369 0.004738780731225134 0.14528310069172062 26732368.122030903 2693405.9749837792 124948010.21129249 0.03751429766246739 7.247354213364881e-13 12.139820512084448 -0.945603234650962 VS(ph)PPQPPPPQPPR ddPTM_A459_Selumetinib_30min_R2 1 VSPPQPPPPQPPR 13 0 Q15637-5 Q15637-5 SF1 Splicing factor 1 1 VS(1)PPQPPPPQPPR 101.53 0.012376 0.0 7681.5 7522.2 8742.4 10714.0 11119.0 7310.5 6335.1 6067.6 6382.7 8777.6 True False 7254.592981480867 8099.128552314796 8179.9235020054175 9254.73471731911 9722.1318148788 8317.455016888365 6629.694702762499 6085.255711454748 7659.418347538607 8524.167881056324 0.8510617203590164 0.9501371471476865 0.9596154857747536 1.0857053552272662 1.140537346347292 0.9757497896507473 0.7777527138450656 0.7138826682400647 0.8985532024258354 1.0 13.057343291530048 -7.1839120056878665 5.899197081018645 0.8241451054145954 1.0025757329881602 0.31921175318293915 0.10228265132185796 0.24420774202129633 14.51354337766133 0.04140060671370371 0.031826470683427824 6.547688262154269e-08 7.1839120056878665 0.17843062757356476 VS(ph)PQDANPLMANGTLTR ddPTM_A459_Selumetinib_30min_R2 2 VSPQDANPLMANGTLTR 17 0 O60716-5;O60716-3;A0A669KB05;O60716;O60716-2;O60716-8;O60716-7;A0A669KB62;C9JZR2;O60716-4;O60716-6 O60716-5 CTNND1 Catenin delta-1 1 VS(1)PQDANPLMANGTLTR;VS(0.998)PQDANPLMANGT(0.002)LTR 166.34 1.4907e-06 9293000.0 13503.1 14583.2 13579.3 17138.2 17675.9 14473.2 15550.6 17085.5 14750.7 13744.599999999999 True False 12752.651759192126 15701.684547621311 12705.622622023948 14803.94759495598 15455.295417449062 16466.751925371544 16273.733712929336 17135.21597634321 17701.252168993957 13347.757685240478 0.955415288464039 1.176353730558334 0.9518919148549885 1.109096220058423 1.157894515461502 1.2336717757155533 1.2192110537730474 1.2837524009962198 1.3261592386088514 1.0 13.70430978078113 -6.333542265291501 1.9024505663481364 1.2308396474410306 1.0421801607768537 0.37524372398309935 0.10060460082960766 0.33453824184863395 2.3857822458402724 0.033893326537673615 0.0421410171637061 4.639356378331648e-07 6.333542265291501 -0.18865948666417687 VS(ph)PQPMISR ddPTM_A459_Selumetinib_30min_R2 4 VSPQPMISR 9 0 Q9P270;D6RIF6 Q9P270 SLAIN2 SLAIN motif-containing protein 2 1 VS(1)PQPMISR;VS(1)PQPMISR;VS(1)PQPMISR;VS(1)PQPMISR 107.34 0.012643 56158100.0 75984.0 65650.0 65411.2 76933.0 81164.0 65288.0 74190.0 80078.0 49383.8 70229.0 True False 71761.11346805209 70685.14390197895 61202.71460632969 66454.59268317268 70967.45270463372 74280.8293745445 77639.982004696 80311.01372237346 59261.93989865997 68201.30629314441 1.0521955863954693 1.0364192087195288 0.8973833190711448 0.9743888540424143 1.0405585546939495 1.0891408597845462 1.1383943537823462 1.177558291584311 0.868926756973524 1.0 16.05751175171082 -6.44489486395369 4.046844670823443 1.070802119958831 0.9873705040240343 0.09537656714721887 0.0877543713716492 0.4472184457812228 13.730189994687588 0.02871482878773981 0.03209835710393706 3.5900883466951267e-07 6.44489486395369 -0.08343161593479664 VS(ph)PSDTTPLVSR ddPTM_A459_Selumetinib_30min_R1 1 VSPSDTTPLVSR 12 0 Q9HCK8-2;Q9HCK8;H0YJG4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 VS(0.999)PS(0.001)DTTPLVSR 196.7 0.00015367 58820000.0 1436.2 1533.2 912.45 1195.2 1365.4 934.45 1337.1 1255.1 690.18 1235.3 True False 1469.6606656412732 1353.6922312346578 788.5443017290835 986.4807566826603 1241.8998110809491 925.0502814127148 1236.2414704946143 1221.810670860631 1171.1850512472395 1393.8627878409568 1.054379726944088 0.9711804081745221 0.5657259154974 0.7077316112374902 0.8909770903666976 0.6636595004057639 0.8869176229387025 0.876564523795898 0.840244148465548 1.0 10.444872833641405 -8.85834430207438 0.8406027034577653 0.9987561899929412 0.8102909495001634 0.12191396265631593 0.13847989846585804 2.593060527073568 3.3743958694411926 0.14484844936292288 0.049311893422209756 1.3856568655744984e-09 8.85834430207438 -0.1884652404927778 VS(ph)PSDTTPLVSR ddPTM_A459_Selumetinib_30min_R2 4 VSPSDTTPLVSR 12 0 Q9HCK8-2;Q9HCK8;H0YJG4 Q9HCK8-2 CHD8 Chromodomain-helicase-DNA-binding protein 8 1 VS(0.829)PS(0.167)DT(0.003)T(0.001)PLVSR;VS(0.999)PS(0.001)DTTPLVSR;VS(0.998)PS(0.002)DTTPLVSR;VS(0.927)PS(0.068)DT(0.004)T(0.001)PLVSR 190.34 0.00013561 194524000.0 150537.0 133191.0 166696.0 156645.0 154415.0 122775.0 144605.0 147934.0 123477.0 139740.0 True False 142170.75618735724 143406.32142343445 155970.96084488207 135309.68077230308 135016.00721238504 139686.1418095163 151329.4190293714 148364.463448208 148175.8502356405 135705.34311187707 1.047643025154507 1.0567477899909115 1.1493354444879726 0.9970844011702045 0.9949203481330596 1.0293341338399433 1.1151323563185989 1.0932838755353547 1.0918940023863513 1.0 17.05011799938852 -7.245859173506071 24.66092469205839 1.0828512184997732 1.0465128828588057 0.06953266733944263 0.04916868266419539 1639.3627871135677 2594845.454072799 0.019677906179435052 0.01519952731962449 5.677286700931115e-08 7.245859173506071 -0.036338335640967445 VS(ph)PSFSAELK ddPTM_A459_Selumetinib_30min_R1 1 VSPSFSAELK 10 0 Q13416 Q13416 ORC2 Origin recognition complex subunit 2 1 VS(0.965)PS(0.034)FS(0.001)AELK 119.74 0.0053049 3213300.0 1096.9 1505.4 1294.7 1595.9 1257.8 1519.6 1390.9 1183.7 1046.9 1239.3 True False 1122.4556358041445 1329.1470681585272 1118.8868512780364 1317.2060237532276 1144.0322120826263 1504.3142036864053 1285.9832931799856 1152.3044308005185 1776.5128374492688 1398.3762268042558 0.8026850101487498 0.9504931810776419 0.8001329183313253 0.9419539595316716 0.8181147463419853 1.0757578503206195 0.9196261124367621 0.8240303351222644 1.2704112122309015 1.0 10.449536848180783 -7.507526332848923 0.6590832313145295 1.0671670187031208 0.8651441110486788 0.2754222330441698 0.11991438145502106 1.0536454396442791 0.8996740471904571 0.10543971432154285 0.062060842065901844 3.107947450904816e-08 7.507526332848923 -0.20202290765444197 VS(ph)PSFSAELK ddPTM_A459_Selumetinib_30min_R2 2 VSPSFSAELK 10 0 Q13416 Q13416 ORC2 Origin recognition complex subunit 2 1 VS(0.993)PS(0.007)FSAELK;VS(0.997)PS(0.003)FSAELK 139.76 0.0014922000000000002 10483100.0 35022.0 33265.0 37414.0 40211.0 31584.0 26565.7 32332.0 34756.0 30101.0 31211.0 True False 33075.61744417405 35816.318536166495 35006.82397328317 34734.19243215592 27616.13555545749 30224.884035585954 33835.502064642584 34857.13420583445 36122.04109221172 30309.85733408323 1.091249525842563 1.1816722903506143 1.1549649867179757 1.145970172320724 0.911127203637588 0.9971965127529081 1.1163200701243416 1.1500263370305555 1.191758862275895 1.0 14.887499441045 -6.07226330606809 24.999756504728396 1.0645421314154921 1.1471961755850564 0.20475069525261635 0.07923941356145714 266.26243164207483 92113.08041234722 0.025762878874840058 0.03325974315210238 8.467139088645e-07 6.07226330606809 0.08265404416956423 VS(ph)PSKSPSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R2 1 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.647)PS(0.044)KS(0.302)PS(0.007)LS(0.001)PSPPS(1)PLEK 132.53 0.00048356 8893500.0 48918.0 48378.0 46941.0 48396.0 44620.0 36072.0 45266.0 42524.0 31099.0 42046.0 True False 46199.33339426948 52088.4370402123 43920.867165496486 41804.38131224338 39014.43669213884 41040.59057098652 47370.95869287737 42647.737799772854 37319.66897866155 40832.022731372395 1.1314485617871002 1.275676137400641 1.075647597828918 1.0238136275361125 0.9554862601054283 1.0051079477738896 1.160142347209288 1.0444679187300068 0.9139804124861 1.0 15.31741341691997 -5.452377347584103 4.576630319661279 1.0212356651637837 1.2022199333647112 0.5402762849777926 0.06857248502924389 0.16847718052549923 6.669957972618856 0.018940936919987366 0.040286352785015835 3.5287643107092926e-06 5.452377347584103 0.1809842682009275 VS(ph)PSPSQESLSSSK ddPTM_A459_Selumetinib_30min_R1 2 VSPSPSQESLSSSK 14 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83;Q5JSH3-3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 VS(0.938)PS(0.061)PSQESLSSSK;VS(0.971)PS(0.028)PSQESLSSSK 116.78 0.0034005000000000003 16850000.0 1549.88 1614.6599999999999 1242.75 914.33 2480.5 3299.6 2855.7 3029.8999999999996 2187.52 2128.8199999999997 True False 1585.9891884584993 1425.614856564931 1073.9913759371125 754.6594295997801 2256.1392129678447 3266.4090197970936 2640.2922498627395 2949.5372094977533 3712.061669860563 2402.074783462789 0.6602580399983071 0.5934931195230273 0.4471098832272263 0.3141698313454988 0.9392460336790321 1.3598281961431256 1.0991715445497248 1.2279123155548688 1.545356412471605 1.0 11.23006535163046 -6.488918623294111 4.051798651342571 1.2475156328346768 0.509895054980452 0.8237878222275196 0.16164998384627757 0.08879299246952659 3.1944545943561904 0.05358906904464647 0.05837735724998734 3.244003967598319e-07 6.488918623294111 -0.7376205778542249 VS(ph)PSPSQESLSSSK ddPTM_A459_Selumetinib_30min_R2 2 VSPSPSQESLSSSK 14 0 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83;Q5JSH3-3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 VS(0.608)PS(0.39)PS(0.001)QESLSSSK;VS(0.997)PS(0.003)PSQESLSSSK 133.48 0.0010871 0.0 11543.8 4721.5 13139.4 11829.6 19168.8 14428.5 14886.1 14782.1 8512.099999999999 5358.5 True False 10902.241809492789 5083.623867984672 12294.02530909705 10218.388072801765 16760.643972753718 16415.894906117737 15578.333146247554 14825.113463691605 10214.757847945755 5203.786181944987 2.095059525566042 0.9769086757681879 2.362515460714411 1.9636448761587089 3.220855620645273 3.1546059603821135 2.993653582519975 2.8489090337971024 1.9629472639338628 1.0 12.345345969126525 -5.683266943973079 1.9121386882349485 2.6511908535740623 1.5732626407540165 0.16380300448032414 0.7116353056030639 0.4530011856419632 3.3505198392053073 0.2085095371555725 0.4570306275585715 2.0736385404748327e-06 5.683266943973079 -1.0779282128200458 VS(ph)PSTSYTPSR ddPTM_A459_Selumetinib_30min_R2 1 VSPSTSYTPSR 11 0 Q9BTE3;Q9BTE3-2 Q9BTE3 MCMBP Mini-chromosome maintenance complex-binding protein 1 VS(1)PSTSYTPSR 142.76 0.00089481 57054000.0 34606.0 30048.0 33833.0 35743.0 47858.0 26733.0 27611.0 33448.0 36239.0 30703.0 True False 32682.737058794108 32352.584980451837 31656.22161458516 30874.74173988582 41845.650184051585 30415.228091987792 28894.966210158553 33545.32814238551 43487.812602261074 29816.52461402575 1.0961283208513204 1.0850555321002475 1.0617005846380236 1.0354909614570666 1.4034382184289618 1.0200795862600436 0.9690923601661579 1.125058288201896 1.4585137994856825 1.0 14.863824487797636 VS(ph)RLSTSTTIENIEITIK ddPTM_A459_Selumetinib_30min_R1 1 VSRLSTSTTIENIEITIK 18 1 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 VS(0.632)RLS(0.252)T(0.043)S(0.06)T(0.011)T(0.003)IENIEITIK 99.923 0.0016010000000000002 9089000.0 2431.6 2934.3 3543.9 2908.7 2593.1 2661.8 3525.9 3017.1 1791.1 2730.7 True False 2488.2515489300367 2590.7507918809392 3062.6578452492736 2400.750148061292 2358.5545628489895 2635.0247087210296 3259.938524281624 2937.076707078011 3039.3658832318124 3081.2119442704598 0.8075561155593214 0.8408220008034379 0.993978311340871 0.7791577442523899 0.7654632675414432 0.8551909950955762 1.0580052859860898 0.9532212519620828 0.9864189605273793 1.0 11.589282207685672 -7.1863185688678675 7.034636056773954 0.9952156075520887 0.8404359719952365 0.6029781720466016 0.06322936346649626 0.20043315369594 16.16719316267595 0.02568593869317187 0.019830828792876246 6.511505790974423e-08 7.1863185688678675 -0.15477963555685226 VS(ph)SPAGPTEDNDLSR ddPTM_A459_Selumetinib_30min_R1 1 VSSPAGPTEDNDLSR 15 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 VS(0.605)S(0.395)PAGPTEDNDLSR 141.06 0.00038699 4981900.0 888.11 940.94 1188.8 1061.8 813.81 743.39 832.88 816.57 507.51 885.78 True False 908.8012350387626 830.7743073688621 1027.3674896109749 876.3765624545255 740.2010291898249 735.9121715441153 770.055191044465 794.911911006825 861.2074029361712 999.4784912278495 0.9092754301518877 0.8312077895225779 1.0279035503293963 0.8768338389932788 0.7405872519382535 0.7362961564486039 0.7704569911239008 0.7953266808476124 0.8616567644974394 1.0 9.965031710288596 -6.009716137432413 24.809930709732132 0.8014760122611398 0.9200921217016542 0.22848037608151595 0.08463455251835246 533.373763858657 1361964.3717832484 0.023705794089776473 0.032991688149214646 9.778761693079675e-07 6.009716137432413 0.11861610944051437 VS(ph)SPSPATDGK ddPTM_A459_Selumetinib_30min_R2 1 VSSPSPATDGK 11 0 A0A0A0MQS0;F8W9L8;A8MW92-4;A8MW92 A0A0A0MQS0 PHF20L1 PHD finger protein 20-like protein 1 1 VS(0.5)S(0.5)PSPATDGK 142.89 0.00088397 9129700.0 110200.0 95299.0 97957.0 104700.0 107700.0 81469.0 86680.0 104650.0 102460.0 111830.0 True False 104075.52516555248 102608.12686541778 91654.55326751749 90439.67938242582 94169.76314978386 92690.61524805125 90710.79175316152 104954.51417426 122954.86297159587 108601.17733076592 0.9583277798966241 0.9448159714963758 0.8439554295840256 0.8327688668325782 0.8671154904975994 0.8534954917269822 0.8352652704388668 0.9664215135955727 1.1321687848476358 1.0 16.728680217726883 -8.002391125849627 4.704850475218372 1.0641127343450278 0.8756995730466124 0.6930160980472735 0.050577376218487784 0.10539110165150038 6.246429936563029 0.03412258155921997 0.01392328071261035 9.945093582405846e-09 8.002391125849627 -0.18841316129841545 VS(ph)SPTVNTTLR ddPTM_A459_Selumetinib_30min_R2 1 VSSPTVNTTLR 11 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 VS(0.914)S(0.085)PT(0.001)VNTTLR 155.47 0.00053471 14531000.0 39664.0 34578.0 34815.0 39651.0 45616.0 27690.0 31695.0 33433.0 27091.0 37749.0 True False 37459.6336675724 37230.02141420606 32575.04080370593 34250.46539820981 39885.31026778586 31504.04615520675 33168.88030245102 33530.28449486888 32509.95698578475 36659.08828631919 1.0218375693088901 1.0155741223957262 0.8885938610716245 0.9342967051090506 1.08800606158748 0.85937887786925 0.9047928318181694 0.9146513473817638 0.8868184809145171 1.0 15.161883285962928 -6.7967055483381715 24.999819644093154 0.9072730777789042 0.9824108580430005 0.2813590675748723 0.06024316942421032 250.64597472115307 177678.6085266358 0.021445974811648207 0.01891424332008461 1.596961520192917e-07 6.7967055483381715 0.07513778026409634 VS(ph)SPVFGATSSIK ddPTM_A459_Selumetinib_30min_R2 1 VSSPVFGATSSIK 13 0 F6Q6H0;I6L8A6;Q99708-3;Q99708;Q99708-2 F6Q6H0 RBBP8 DNA endonuclease RBBP8 1 VS(0.897)S(0.103)PVFGATSSIK 237.59 1.2197e-17 40048000.0 104660.0 83485.0 98844.0 111800.0 99788.0 73941.0 88192.0 81389.0 72349.0 94825.0 True False 98843.41618717542 89888.03105341509 92484.48465321018 96572.64713424277 87251.73932396123 84125.70158043125 92293.10274913271 81625.8285153257 86820.82159996103 92087.15586506162 1.0733681071876513 0.9761190929289968 1.0043147036567268 1.0487091954034706 0.9474908688874495 0.9135443568666998 1.0022364344097332 0.8863975409875265 0.9428114136479844 1.0 16.490712325638093 -6.278882674630234 21.884094774331746 0.9439809686101819 1.0205690643126344 0.45646525114259495 0.040752138528136 144.13820775134752 180832.63146661985 0.012204983500949274 0.013888256967329501 5.261593900184125e-07 6.278882674630234 0.07658809570245251 VS(ph)SSSPQSGCPSPTIPAGK ddPTM_A459_Selumetinib_30min_R2 1 VSSSSPQSGCPSPTIPAGK 19 0 E7EWD6;Q76L83;A0A5F9ZHC8 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 VS(0.675)S(0.108)S(0.108)S(0.108)PQSGCPSPTIPAGK 236.27 1.3648e-29 5388100.0 54722.0 41578.0 55210.0 54762.0 59457.0 46155.0 49334.0 50734.0 48073.0 45329.0 True False 51680.77030952235 44766.89890565848 51657.848708102945 47303.32113028087 51987.48010767593 52512.43229662571 51628.12875346643 50881.62754053416 57688.94327184787 44020.23399111401 1.1740230712984103 1.0169618570109191 1.1735023652652705 1.0745813195774832 1.1809905444430442 1.1929157920247755 1.1728272222244016 1.1558690839945376 1.310509691599846 1.0 15.425879193495925 -6.278284234203209 23.63429688645161 1.1780474656861775 1.1076907204475304 0.10346441730811906 0.08249552478618657 759.1838157510426 1065174.8167219567 0.023868829131331464 0.027151307531212046 5.268849163731528e-07 6.278284234203209 -0.0703567452386471 VSAEAEVAPVS(ph)PEVT(ph)QEVVEEHCASPEDK ddPTM_A459_Selumetinib_30min_R2 2 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VSAEAEVAPVS(0.991)PEVT(0.936)QEVVEEHCAS(0.073)PEDK;VSAEAEVAPVS(0.993)PEVT(0.882)QEVVEEHCAS(0.124)PEDK 77.641 9.206e-05 14659300.0 47237.0 43940.0 46000.0 46636.0 47963.0 34177.0 45786.0 41754.0 36229.0 47829.0 True False 44611.75664469335 47310.056710631485 43040.410081013106 40284.09634841274 41937.459145339686 38884.57152208382 47915.13972323783 41875.4972272532 43475.81232283769 46448.05249533392 0.960465600773573 1.0185584576529696 0.926635408133352 0.8672935501969562 0.9028895054222702 0.8371625812727043 1.0315855487816479 0.9015555007706714 0.9360093693315815 1.0 15.503330487153598 -10.461623264056259 15.008706709231616 0.9999984038823453 0.930357268212875 0.11299602756723581 0.05764132787469589 0.0 0.0 0.05780146778387574 0.01401891511697977 3.454432698884902e-11 10.461623264056259 -0.06964113566947028 VSAEAEVAPVS(ph)PEVTQEVVEEHCAS(ph)PEDK ddPTM_A459_Selumetinib_30min_R1 4 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VSAEAEVAPVS(0.965)PEVT(0.035)QEVVEEHCAS(1)PEDK;VSAEAEVAPVS(0.999)PEVT(0.026)QEVVEEHCAS(0.974)PEDK;VSAEAEVAPVS(1)PEVT(0.001)QEVVEEHCAS(1)PEDK;VSAEAEVAPVS(1)PEVTQEVVEEHCAS(1)PEDK 164.49 4.3026e-19 442980000.0 16005.0 23162.300000000003 16641.4 16248.4 15260.9 17233.5 18285.9 18138.5 10939.3 17301.3 True False 16377.885359691245 20450.44714813887 14381.589284666965 13410.921960243093 13880.554289530726 17060.146636766047 16906.579840937462 17657.408057848435 18563.19312513973 19522.090383933257 0.8389411706222966 1.0475541679168565 0.7366828552593455 0.6869613702475389 0.7110178273200941 0.8738893377323261 0.8660230287045301 0.9044834702937622 0.950881425096633 1.0 14.2528199214393 -7.92900602060916 1.177326845264983 0.9891269794929792 0.8125885119622573 0.3126221776373945 0.0956164757776603 0.6783543509566495 1.6970037609868527 0.09572101937962305 0.034451116776894414 1.1775896485236844e-08 7.92900602060916 -0.1765384675307219 VSAEAEVAPVS(ph)PEVTQEVVEEHCAS(ph)PEDK ddPTM_A459_Selumetinib_30min_R2 5 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VSAEAEVAPVS(0.997)PEVT(0.003)QEVVEEHCAS(1)PEDK;VSAEAEVAPVS(0.988)PEVT(0.056)QEVVEEHCAS(0.955)PEDK;VSAEAEVAPVS(0.533)PEVT(0.517)QEVVEEHCAS(0.949)PEDK;VSAEAEVAPVS(0.991)PEVT(0.061)QEVVEEHCAS(0.948)PEDK;VSAEAEVAPVS(0.99)PEVT(0.022)QEVVEEHCAS(0.989)PEDK 126.52 4.8525e-13 129241400.0 152858.6 138913.5 140941.0 151374.5 151368.5 127247.0 151195.8 148021.6 116432.5 159246.2 True False 144363.33095345838 149567.7187726966 131873.0095049582 130757.03196442222 132352.2357784406 144774.11921674223 158226.70428879384 148452.31834970514 139722.25339586532 154648.3484346831 0.933494165406049 0.9671472103426157 0.8527282110656084 0.8455119843691602 0.855827023812935 0.9361504386054835 1.0231386619406548 0.9599347154515853 0.9034836440873991 1.0 17.238631900700618 -6.985679179459558 9.218197445362167 0.9699323842889027 0.8909951727400018 0.4134299872626337 0.04541585639245686 0.2256360782314548 125.4635401018166 0.017677550105211413 0.015346750187007102 1.0335246056089127e-07 6.985679179459558 -0.07893721154890088 VSAEAEVAPVS(ph)PEVTQEVVEEHCASPEDK ddPTM_A459_Selumetinib_30min_R1 5 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VSAEAEVAPVS(0.819)PEVT(0.181)QEVVEEHCASPEDK;VSAEAEVAPVS(1)PEVTQEVVEEHCASPEDK;VSAEAEVAPVS(1)PEVTQEVVEEHCASPEDK;VSAEAEVAPVS(0.991)PEVT(0.009)QEVVEEHCASPEDK;VSAEAEVAPVS(0.521)PEVT(0.477)QEVVEEHCAS(0.002)PEDK 162.87 2.1914e-19 2338513000.0 19542.69 23126.299999999996 21609.2 23350.7 21017.699999999997 20493.269999999997 20820.46 19319.89 11828.07 17642.7 True False 19997.996653544804 20418.662044874807 18674.789330839078 19272.93859192588 19116.652745976317 20287.126310200398 19249.955939551477 18807.463757352885 20071.370901947244 19907.31239945087 1.0045553238063634 1.0256865233821337 0.9380869178179073 0.9681336287492784 0.9602829534389401 1.0190791154088688 0.9669791458179193 0.944751525468183 1.0082411175956076 1.0 14.28101084170746 VSAEAEVAPVS(ph)PEVTQEVVEEHCASPEDK ddPTM_A459_Selumetinib_30min_R2 4 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VSAEAEVAPVS(0.973)PEVT(0.027)QEVVEEHCASPEDK;VSAEAEVAPVS(0.947)PEVT(0.053)QEVVEEHCASPEDK;VSAEAEVAPVS(0.802)PEVT(0.198)QEVVEEHCASPEDK;VSAEAEVAPVS(0.999)PEVT(0.001)QEVVEEHCASPEDK 126.16 8.146200000000001e-14 512600000.0 54227.4 55551.5 63817.1 61499.0 59226.8 45897.6 49784.2 50759.0 43386.0 57635.2 True False 51213.65819748169 59812.12142377434 59711.177264804865 53122.73010830759 51786.19988969003 52219.57778307028 52099.26394552083 50906.70028639516 52064.41230612594 55971.12202176652 0.915001456957845 1.068624663277504 1.0668211589823746 0.9491096156273011 0.9252306907399673 0.9329735745294278 0.9308240046583313 0.9095172375961685 0.930201332856588 1.0 15.772395048473175 -5.893788603523836 6.586138225982351 0.9333881019518303 1.0215166152106592 0.37349633087236644 0.04553852297637803 0.19615697178107483 10.803501908887407 0.012580294265202411 0.0188101263218941 1.2770602773315916e-06 5.893788603523836 0.08812851325882887 VSAEAEVAPVSPEVT(ph)QEVVEEHCASPEDK ddPTM_A459_Selumetinib_30min_R1 3 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VSAEAEVAPVS(0.011)PEVT(0.689)QEVVEEHCAS(0.3)PEDK;VSAEAEVAPVS(0.034)PEVT(0.966)QEVVEEHCASPEDK;VSAEAEVAPVS(0.089)PEVT(0.911)QEVVEEHCASPEDK 120.54 1.8662999999999998e-13 281757800.0 4191.76 5036.0199999999995 3685.47 4738.639999999999 4317.47 4508.01 4248.68 4039.6099999999997 2522.25 3914.0900000000006 True False 4289.419852254884 4446.400437217818 3185.0034168376196 3911.125479289428 3926.9556008112395 4462.663512345589 3928.1986469681074 3932.4664202974423 4280.074032148647 4416.501577965202 0.9712257035422892 1.006769806084025 0.7211598050203877 0.8855709457464715 0.8891552581807275 1.0104521494140741 0.8894367131139872 0.8904030375347975 0.969109589703937 1.0 12.108688311613044 -6.627139680607078 19.167476302833947 0.9421022305939226 0.890789424381371 0.10766759159535777 0.07932666986420366 6.327918665891859 1137.3499934875408 0.02737731117915778 0.027377182710988816 2.3597191629418243e-07 6.627139680607078 -0.05131280621255163 VSAEAEVAPVSPEVT(ph)QEVVEEHCASPEDK ddPTM_A459_Selumetinib_30min_R2 4 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VSAEAEVAPVS(0.013)PEVT(0.987)QEVVEEHCASPEDK;VSAEAEVAPVS(0.018)PEVT(0.967)QEVVEEHCAS(0.015)PEDK;VSAEAEVAPVS(0.496)PEVT(0.504)QEVVEEHCASPEDK;VSAEAEVAPVS(0.006)PEVT(0.988)QEVVEEHCAS(0.006)PEDK 143.84 1.5913999999999995e-14 662741700.0 442679.0 409098.0 412255.0 405473.0 439450.0 333284.0 381853.0 380412.0 291491.0 418181.0 True False 418076.6733644429 440474.5011426014 385730.96212930663 350246.8779200607 384242.3622671541 379190.8457490759 399609.9211273646 381518.93593940284 349797.34493903484 406107.0279652768 1.0294741153807108 1.0846266398035918 0.949825872410875 0.8624496839537772 0.9461603365800599 0.9337214567522768 0.9840014912559758 0.9394541578138453 0.8613427516672857 1.0 18.631500468758688 -5.335631880476838 5.575236946574061 0.9311399633086449 1.0566178181141153 0.5573166243507041 0.0437225970023457 0.14031771337396676 7.793112962799416 0.01138347618756214 0.024501035635775433 4.6170876534212475e-06 5.335631880476838 0.12547785480547036 VSAEAEVAPVSPEVTQEVVEEHCAS(ph)PEDK ddPTM_A459_Selumetinib_30min_R1 1 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VSAEAEVAPVS(0.002)PEVT(0.345)QEVVEEHCAS(0.652)PEDK 127.28 7.8151e-14 62407000.0 1662.9 2258.5 1743.9 1873.6 1629.2 1951.5 1654.2 2058.8 1238.0 1808.4 True False 1701.6423345598605 1994.073770051835 1507.0879585570156 1546.4109318278386 1481.8391476586226 1931.8696818202307 1529.4223621959386 2004.1939360751085 2100.795580057496 2040.5257553076876 0.8339234778750796 0.977235285986945 0.738578258390943 0.7578492590967849 0.7262045792875466 0.9467509423956901 0.7495236745812696 0.982194873483917 1.029536419519841 1.0 10.994725204922487 -7.860847950616199 6.132795601767215 1.0107820688040434 0.8209770499890799 0.5235195028238553 0.08123510056974885 0.1759699613564132 9.12808758849329 0.04646007730273188 0.022030361673350027 1.3776917234952733e-08 7.860847950616199 -0.18980501881496348 VSAEAEVAPVSPEVTQEVVEEHCAS(ph)PEDK ddPTM_A459_Selumetinib_30min_R2 4 VSAEAEVAPVSPEVTQEVVEEHCASPEDK 29 0 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VSAEAEVAPVSPEVT(0.008)QEVVEEHCAS(0.991)PEDK;VSAEAEVAPVS(0.026)PEVT(0.029)QEVVEEHCAS(0.945)PEDK;VSAEAEVAPVSPEVTQEVVEEHCAS(1)PEDK;VSAEAEVAPVSPEVTQEVVEEHCAS(1)PEDK 151.5 5.302e-16 34430600.0 218991.0 196971.0 199186.0 201847.0 198838.0 159426.0 195590.0 194759.0 148978.0 200784.0 True False 206820.3569104312 212078.04233841103 186370.58961731874 174355.0903945036 173858.19280572634 181385.484374864 204685.32255423252 195325.71644591202 178777.76279311356 194986.84422051703 1.0606887748618121 1.0876530833975906 0.955811097729989 0.8941889956294677 0.8916406309397181 0.930244730612334 1.0497391420046123 1.0017379235340194 0.91687089715103 1.0 17.57301726293432 -5.266359686355808 23.68553049534318 0.9531518374490535 1.0741709395387211 0.4926916706288301 0.048328420836471396 160.45146624630013 772396.0663648477 0.014007977644880468 0.030781251886866083 5.415521865249609e-06 5.266359686355808 0.1210191020896676 VSAGEPGSHPS(ph)PAPR ddPTM_A459_Selumetinib_30min_R1 4 VSAGEPGSHPSPAPR 15 0 C9JME2;Q9Y4F1;Q9Y4F1-2;A0A1B0GV68 C9JME2 FARP1 FERM, RhoGEF and pleckstrin domain-containing protein 1 1 VSAGEPGS(0.002)HPS(0.998)PAPR;VSAGEPGSHPS(1)PAPR;VSAGEPGS(0.003)HPS(0.997)PAPR;VSAGEPGSHPS(1)PAPR 217.79 3.0723e-09 74178200.0 10087.05 9811.42 10966.400000000001 9850.32 11908.100000000002 9701.4 9510.11 10249.96 3300.54 7359.37 True False 10322.058639017407 8662.694385194583 9477.223114123319 8130.146525406916 10831.014457545809 9603.81272416643 8792.754746066512 9978.097764237618 5600.775318096097 8304.016825834295 1.2430199571495162 1.0431932601875784 1.1412817812024547 0.9790619041273547 1.3043102735353176 1.156526163854629 1.0588556033161836 1.2015989338069688 0.6744657959593421 1.0 13.019593651590432 -8.249749579153487 24.993260517536964 0.8372328869063198 1.1355590929301251 0.5187136591069901 0.1169405680820248 484.7025438838251 1036318.9675664767 0.07550264665802663 0.028016774206687675 5.6266567330992065e-09 8.249749579153487 0.29832620602380533 VSAGEPGSHPS(ph)PAPR ddPTM_A459_Selumetinib_30min_R2 4 VSAGEPGSHPSPAPR 15 0 C9JME2;Q9Y4F1;Q9Y4F1-2;A0A1B0GV68 C9JME2 FARP1 FERM, RhoGEF and pleckstrin domain-containing protein 1 1 VSAGEPGS(0.002)HPS(0.998)PAPR;VSAGEPGSHPS(1)PAPR;VSAGEPGS(0.013)HPS(0.987)PAPR;VSAGEPGS(0.001)HPS(0.999)PAPR 98.582 0.0058132 56918200.0 102494.9 57116.6 83597.3 104796.9 69450.7 62335.0 128361.0 96949.5 76314.59999999999 71618.8 True False 96798.64377759343 61497.25956118466 78218.74073185811 90523.38143526424 60725.68216886436 70921.08042920961 134330.04084249627 97231.60699414629 91579.65240808297 69550.97915601054 1.3917653633669682 0.8842040803370936 1.1246245801429313 1.3015400003529825 0.8731103847244184 1.019699237736478 1.9313896435761044 1.397990483729137 1.3167270039816361 1.0 16.085783205080112 VSALVQS(ph)PQMK ddPTM_A459_Selumetinib_30min_R2 2 VSALVQSPQMK 11 0 Q5VV67-2;Q5VV67;E7EVG6;X6R7H2 Q5VV67-2 PPRC1 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 1 VSALVQS(1)PQMK;VS(0.001)ALVQS(0.999)PQMK 127.02 0.0034354 0.0 52685.0 58908.0 60401.0 62442.0 64444.0 60842.0 52634.0 50887.0 47677.0 58353.0 True False 49756.97861476531 63426.05418092575 56514.86541963639 53937.29188154186 56347.968583330265 69222.43323131409 55081.58529229241 51035.072745203644 57213.73220668341 56668.19727069812 0.878040612039966 1.1192530773115306 0.997294216889779 0.9518088536307057 0.9943490581527032 1.2215393565573593 0.9720017213389262 0.9005946051435937 1.0096268270786757 1.0 15.790251687696701 -7.494736347410062 24.988825077936593 0.960325965490945 1.0309625656949504 0.07996916470597826 0.09154873441123286 1593.9128934388038 1415307.297203323 0.038429539787869026 0.025845284940014153 3.200837692600832e-08 7.494736347410062 0.07063660020400542 VSAS(ph)SPSLAVASQSDSK ddPTM_A459_Selumetinib_30min_R2 1 VSASSPSLAVASQSDSK 17 0 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;D6RDA9;Q3MSN4 P04150-3 NR3C1 Glucocorticoid receptor 1 VSAS(0.499)S(0.499)PS(0.003)LAVASQSDSK 273.77 6.0049e-52 15657000.0 99147.0 86000.0 94909.0 112370.0 99911.0 68375.0 82710.0 83835.0 59661.0 79473.0 True False 93636.80665688771 92595.92346641557 88802.65826910583 97065.01215093797 87359.28696432736 77793.03560354853 86556.17888675588 84078.94597036872 71594.86706762048 77178.40799434797 1.2132513366140572 1.1997646216438758 1.1506153155635075 1.2576705671105104 1.1319135653941574 1.0079637248962892 1.1215077006135534 1.0894102140138222 0.9276541059626885 1.0 16.235909664393276 -6.998146918218115 0.5985337088672716 0.9862354600528719 1.2183795590750197 0.6768769017125462 0.056551190045267985 0.525176128473513 0.39866311214672956 0.0504989961762075 0.04618116322119069 1.0042759945742126e-07 6.998146918218115 0.23214409902214783 VSAS(ph)SPTTK ddPTM_A459_Selumetinib_30min_R1 2 VSASSPTTK 9 0 Q5JWZ0;Q5JXL1;Q9BVI0 Q5JWZ0 PHF20 PHD finger protein 20 1 VS(0.001)AS(0.966)S(0.033)PTTK;VS(0.004)AS(0.671)S(0.325)PTTK 166.66 0.00089327 61090000.0 18192.6 20529.6 19082.6 19629.3 17504.199999999997 16670.4 18569.6 18163.8 10652.7 14627.2 True False 18616.452183362646 18125.9848880479 16491.287733218713 16201.411242596172 15920.948200617511 16502.710911512146 17168.880121529273 17682.03701966246 18076.853857575534 16504.743600993468 1.1279455551337416 1.0982288078050995 0.9991847272456904 0.9816215043547215 0.9646286295328564 0.9998768421048844 1.0402391298278533 1.0713306093769386 1.095252025392714 1.0 14.01059310620754 -5.141806946004066 4.284174410620193 1.0185011230405288 1.121229895182029 0.4967993562231914 0.03825126619767594 0.20802308297236816 6.174210905881668 0.011365552290163212 0.03402777170333796 7.2142809948174825e-06 5.141806946004066 0.10272877214150022 VSAS(ph)SPTTK ddPTM_A459_Selumetinib_30min_R2 2 VSASSPTTK 9 0 Q5JWZ0;Q5JXL1;Q9BVI0 Q5JWZ0 PHF20 PHD finger protein 20 1 VS(0.001)AS(0.843)S(0.147)PT(0.008)T(0.001)K;VSAS(0.498)S(0.498)PT(0.003)TK 150.15 0.0013502 30577000.0 178515.0 154549.0 155944.0 185847.0 188948.0 135603.0 157891.0 166048.0 138661.0 184878.0 True False 168593.8509521654 166402.41134664064 145910.7328189892 160534.3179960428 165210.66302344788 154281.08236852652 165233.24435508103 166531.1721892736 166397.07451204816 179540.0917692685 0.9390317744118657 0.9268259234293396 0.8126916466462697 0.894141895629359 0.920188139570321 0.8593127075305109 0.9203139127690011 0.9275430938471783 0.9267961983994596 1.0 17.453946512013218 -8.685431972368054 0.7292647715056697 0.9998207207466989 0.8913897865394407 0.4433318138260568 0.03518844555393285 0.8738026137573379 0.9934038707697759 0.036457684735424795 0.013607916703877662 2.063326840300675e-09 8.685431972368054 -0.10843093420725824 VSASS(ph)PSLAVASQSDSK ddPTM_A459_Selumetinib_30min_R2 1 VSASSPSLAVASQSDSK 17 0 P04150-3;A0A494C0P1;P04150;P04150-10;P04150-7;P04150-5;P04150-6;P04150-2;P04150-9;P04150-8;D6RDA9;Q3MSN4 P04150-3 NR3C1 Glucocorticoid receptor 1 VSAS(0.205)S(0.795)PSLAVASQSDSK 303.45 2.0105e-89 15688000.0 76397.0 59947.0 63410.0 74283.0 74941.0 55149.0 62960.0 61017.0 46942.0 64624.0 True False 72151.1605814222 64544.74214001416 59330.26963558789 64165.527254677516 65526.241598959576 62745.274157222666 65887.76475287322 61194.5493680919 56331.71166906756 62758.13720668334 1.149670206810067 1.028468100119781 0.9453797113224321 1.022425618583279 1.0441074976964333 0.999795037742782 1.0498680758462122 0.9750854963485925 0.8976001228900177 1.0 15.937514910272219 -4.79441958107524 3.6410646789367616 0.9957078809564252 1.1645379267762037 0.543649675081509 0.043241401532901416 0.20938975271890747 4.760482196614 0.011322950556475054 0.09443937232967475 1.60538950282506e-05 4.79441958107524 0.16883004581977856 VSASS(ph)PTTK ddPTM_A459_Selumetinib_30min_R1 1 VSASSPTTK 9 0 Q5JWZ0;Q5JXL1;Q9BVI0 Q5JWZ0 PHF20 PHD finger protein 20 1 VSAS(0.263)S(0.734)PT(0.003)TK 99.973 0.018330000000000003 2680900.0 2914.2 3698.7 3646.7 4239.0 3320.4 3716.9 3018.3 3348.1 1790.2 2944.3 True False 2982.0951899539036 3265.6544845210187 3151.4981698892516 3498.7382258850407 3020.070406264235 3679.5113606751797 2790.6272009527283 3259.2975118384825 3037.8386489652107 3322.229584910653 0.8976186364417386 0.9829707433084713 0.9486093869620413 1.05312957351776 0.9090492782260428 1.1075427710918224 0.8399862591157373 0.9810572775108608 0.9143975668517531 1.0 11.69793605981884 -10.065108709002724 11.346519141432841 0.9999999996842805 0.9625126402591778 0.024944603042603042 0.07389062364224172 0.0 0.0 0.06658149786239775 0.01614838519991191 8.607782623206531e-11 10.065108709002724 -0.03748735942510273 VSASS(ph)PTTK ddPTM_A459_Selumetinib_30min_R2 2 VSASSPTTK 9 0 Q5JWZ0;Q5JXL1;Q9BVI0 Q5JWZ0 PHF20 PHD finger protein 20 1 VS(0.001)AS(0.436)S(0.552)PT(0.009)T(0.001)K;VSAS(0.018)S(0.859)PT(0.122)TK 146.71 0.0017163 30318000.0 182264.0 159141.0 183314.0 195951.0 192846.0 159230.0 172884.0 186505.0 142099.0 196873.0 True False 172134.49654060128 171346.60298103344 171519.77681719186 169262.13576567062 168618.96141488585 181162.48715397497 180923.44856314678 187047.6986724353 170522.77057779484 191188.76495251592 0.9003379282425565 0.8962169038729314 0.897122677997271 0.8853142380396095 0.881950157776083 0.9475582270692993 0.9463079517673612 0.978340430824431 0.8919079037941705 1.0 17.544638221481797 -6.770628488114181 22.720006113126047 0.9510620500488638 0.8923044189333851 0.5696401414647811 0.026329182214292896 46.932218895016106 116037.67661505193 0.008654949185235104 0.0077570146011695 1.6957878210421998e-07 6.770628488114181 -0.058757631115478715 VSCHDS(ph)DDDIMR ddPTM_A459_Selumetinib_30min_R1 2 VSCHDSDDDIMR 12 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 VSCHDS(1)DDDIMR;VSCHDS(1)DDDIMR 208.82 7.7532e-06 9848200.0 2500.9 2827.9 2146.05 2449.2 3094.6 2548.6 3163.5 2490.7 798.4300000000001 1892.6399999999999 True False 2559.166104095711 2496.808153344956 1854.6281974088436 2021.493197178023 2814.6939763960045 2522.963397943653 2924.8746480515397 2424.638545066189 1354.8773949800545 2135.578779874775 1.1983477866575234 1.169148231324607 0.8684428853135515 0.9465786119566885 1.3180005359301477 1.1813956112129909 1.3695934215187542 1.1353542973527597 0.6344310065955521 1.0 11.060411403545118 -8.229788973262563 18.585261309683432 0.817218568120002 1.1471260694740744 0.39579355869199206 0.16365065872183626 27.289463745318077 16025.02609663269 0.1168449314133924 0.04410692917114805 5.8912984814722996e-09 8.229788973262563 0.3299075013540723 VSCHDS(ph)DDDIMR ddPTM_A459_Selumetinib_30min_R2 4 VSCHDSDDDIMR 12 0 Q76FK4-2;Q76FK4-4;Q76FK4;F8WE42;F5H101;F5GWN9 Q76FK4-2 NOL8 Nucleolar protein 8 1 VSCHDS(1)DDDIMR;VS(0.003)CHDS(0.997)DDDIMR;VSCHDS(1)DDDIMR;VS(0.011)CHDS(0.989)DDDIMR 269.14 1.0962e-33 103220000.0 194659.0 152282.0 268202.0 317260.0 324255.0 246416.0 200532.0 225259.0 211902.0 269708.0 True False 183840.6320617177 163961.53973619465 250946.1753162585 274048.64069597336 283519.1880235208 280357.56725826714 209857.1353466196 225914.46639636526 254288.3210365719 261920.82925445845 0.7018938989503385 0.6259965662253785 0.9580993463962426 1.0463033485196118 1.0824614019073655 1.0703904995119622 0.8012235450840814 0.8625295935394558 0.9708594836095624 1.0 17.998771269013474 -5.26801054957249 22.75446177419102 0.9728039717178438 0.6639452026401125 0.6799400737761496 0.08508240705478713 85.38313224645547 295667.1323041467 0.025188956009526066 0.054710675449979124 5.3949751726619894e-06 5.26801054957249 -0.30885876907773135 VSDEVGFGLEHVS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 VSDEVGFGLEHVSR 14 0 Q6VY07-2;Q6VY07 Q6VY07-2 PACS1 Phosphofurin acidic cluster sorting protein 1 1 VSDEVGFGLEHVS(1)R 116.61 0.0017369 3832700.0 3548.3 3857.1 2891.4 2542.7 2875.7 2543.1 2727.7 2741.3 1423.6 2073.1 True False 3630.968486210089 3405.5089388828583 2498.763761323329 2098.665177390396 2615.593442746072 2517.5187229500534 2521.947392916131 2668.5918190026687 2415.7452243698335 2339.20257870403 1.5522248988891443 1.4558418197237049 1.0682117846790762 0.8971711969269043 1.1181560188751025 1.0762294577944653 1.0781226969719506 1.1408126184954563 1.0327216831764137 1.0 11.191801091472678 -5.223502562219491 4.02320181472555 1.053435253968908 1.5261511159568282 0.8875958223534499 0.06477246169459235 0.06586207398536008 2.3626622641327155 0.01760112968519901 0.049507818975210345 5.9771951829547635e-06 5.223502562219491 0.47271586198792015 VSDQNS(ph)PVLPK ddPTM_A459_Selumetinib_30min_R1 3 VSDQNSPVLPK 11 0 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 VSDQNS(1)PVLPK;VSDQNS(1)PVLPK;VSDQNS(1)PVLPK 118.73 0.0052246 329330000.0 26581.6 33887.0 30455.6 34511.0 25877.5 26980.9 27178.800000000003 25321.0 13105.0 22277.8 True False 27200.89956121017 29919.4942863611 26319.896800635936 28484.301701702916 23536.884694043696 26709.496642697126 25128.68123422258 24649.404825800375 22238.227848670045 25137.3726341482 1.082090000299345 1.1902395179405727 1.0470424727237133 1.133145540556933 0.9363303411459041 1.0625413018070653 0.9996542439000242 0.980587955016232 0.8846679472961397 1.0 14.617546246262144 -6.248140355675774 0.6623353201660692 0.9573708070704163 1.145556150805454 0.526170436778662 0.05941793128342456 0.6677390189252885 0.6203443887635763 0.037304265778523416 0.07129796979418157 5.647544274793152e-07 6.248140355675774 0.1881853437350376 VSDQNS(ph)PVLPK ddPTM_A459_Selumetinib_30min_R2 5 VSDQNSPVLPK 11 0 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 VSDQNS(1)PVLPK;VS(0.001)DQNS(0.999)PVLPK;VSDQNS(1)PVLPK;VS(0.005)DQNS(0.995)PVLPK;VSDQNS(1)PVLPK 146.67 0.00068001 573206000.0 1877340.0 1582410.0 1965250.0 1950500.0 2159990.0 1426388.0 1492562.0 1580570.0 1318370.0 1678960.0 True False 1773004.9583874608 1703775.7587498915 1838807.954602414 1684838.5351998215 1888632.7456443983 1622859.999538933 1561969.090455494 1585169.1970225514 1582080.8383355741 1630484.062338031 1.0874101742798161 1.0449508818300033 1.1277681254765883 1.0333364024324463 1.1583264070279813 0.9953240494800265 0.9579787540000299 0.9722077226253286 0.9703135865473907 1.0 20.636868908418364 -6.916619765892779 7.533857913478867 0.9733517902693173 1.0865009779030648 0.7153074892197402 0.03519999381355814 0.11924653371928495 9.221369500439282 0.011571592846048273 0.010201082437710925 1.2116585022276239e-07 6.916619765892779 0.11314918763374748 VSDQNS(ph)PVLPKK ddPTM_A459_Selumetinib_30min_R2 1 VSDQNSPVLPKK 12 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 VS(0.006)DQNS(0.994)PVLPKK 71.692 0.030536 3904400.0 26532.0 33598.0 36269.0 37535.0 34614.0 19639.0 13876.0 17249.0 11952.0 30889.0 True False 25057.45765601126 36174.858565402734 33935.4920267014 32422.668248513433 30265.479866913814 22344.093984908086 14521.261494772372 17299.191734274336 14342.733966782314 29997.15431073971 0.8353278246476894 1.2059430101491746 1.1312903775859724 1.0808581344966224 1.0089450336986812 0.7448737888083057 0.48408796862352405 0.5766944275804458 0.47813648648822893 1.0 14.872538025053588 -6.824872097918113 2.7803679560274754 0.5994468046262693 1.0754842925645025 0.5953629053953913 0.16401333527828357 0.16251872835806191 2.5580744479023467 0.05922593949757844 0.05296255757552115 1.4966763705086064e-07 6.824872097918113 0.4760374879382332 VSDS(ph)PSHIATK ddPTM_A459_Selumetinib_30min_R1 2 VSDSPSHIATK 11 0 Q9P2D3 Q9P2D3 HEATR5B HEAT repeat-containing protein 5B 1 VS(0.026)DS(0.801)PS(0.12)HIAT(0.053)K;VS(0.062)DS(0.733)PS(0.024)HIAT(0.181)K 173.19 0.00020433 30667000.0 5477.6 7018.9 7373.0 8023.0 7564.1 6274.0 6236.7 5986.8 1847.49 4275.1 True False 5605.217422445787 6197.123925001919 6371.787096990004 6621.93366036227 6879.928490550323 6210.8892563362115 5766.260697804022 5828.010616132924 3135.055594669164 4823.850728000387 1.161979865983394 1.284684015827909 1.3208922614467544 1.3727484604622573 1.4262316308038483 1.2875376139408006 1.1953646625782488 1.208165622187233 0.6499072569703513 1.0 12.235969549009212 -8.1222983690567 4.866238811167995 0.830574748470483 1.2956121168543648 0.7467446893386287 0.10719849116934227 0.1072305932127242 3.6975540900210646 0.0776300511101085 0.02785061322699933 7.545736422555408e-09 8.1222983690567 0.4650373683838819 VSDS(ph)PSHIATK ddPTM_A459_Selumetinib_30min_R2 1 VSDSPSHIATK 11 0 Q9P2D3 Q9P2D3 HEATR5B HEAT repeat-containing protein 5B 1 VS(0.027)DS(0.662)PS(0.31)HIATK 127.78 0.0029026 7179500.0 27364.0 21778.0 34611.0 40795.0 51629.0 25981.0 31410.0 35895.0 30420.0 39379.0 True False 25843.218426771145 23448.302572693017 32384.165941607505 35238.650624699745 45142.903450883816 29559.64691796409 32870.62723773424 35999.44850726286 36504.85000581642 38242.02595107059 0.6757805786711377 0.6131553438799071 0.8468213996570678 0.9214640110800206 1.1804527173493025 0.772962367521655 0.8595419939255081 0.9413582992000207 0.9545741654096248 1.0 15.222871334670929 -5.428632089067164 2.9733741705389347 0.942364366117049 0.6427010837371148 0.5895295135686291 0.09956138852732697 0.18771809560939173 3.161670676707705 0.028395392163563862 0.06763939291143925 3.7270731014686756e-06 5.428632089067164 -0.2996632823799342 VSEEQTQPPS(ph)PAGAGMSTAMGR ddPTM_A459_Selumetinib_30min_R1 1 VSEEQTQPPSPAGAGMSTAMGR 22 0 Q16666-3;Q16666-2;Q16666;H3BM18;X6RHM1 Q16666-3 IFI16 Gamma-interferon-inducible protein 16 1 VSEEQTQPPS(0.999)PAGAGMS(0.001)TAMGR 200.2 2.1154e-22 6312800.0 669.95 1130.1 879.72 1114.0 1068.2 605.81 831.91 594.23 436.65 712.17 True False 685.5585315042272 997.7873666307634 760.2588559560628 919.4608123698829 971.5814986060278 599.7161014314697 769.1583589254169 578.4690900689295 740.9631583458046 803.583956623245 0.8531262052381252 1.241671586903731 0.9460851597271313 1.1442000612276608 1.2090603484528593 0.7463017354795731 0.9571599240949402 0.7198614224451733 0.9220731103933677 1.0 9.650304951044621 -6.763607949464232 24.99992988004095 0.8570756214661044 1.0841326046911324 0.37455487745133 0.13498972212356944 56.036994729037275 646005.249193916 0.043575600581511977 0.04031166998211787 1.7234236587260264e-07 6.763607949464232 0.227056983225028 VSEEQTQPPS(ph)PAGAGMSTAMGR ddPTM_A459_Selumetinib_30min_R2 4 VSEEQTQPPSPAGAGMSTAMGR 22 0 Q16666-3;Q16666-2;Q16666;H3BM18;X6RHM1 Q16666-3 IFI16 Gamma-interferon-inducible protein 16 1 VSEEQTQPPS(0.999)PAGAGMSTAMGR;VSEEQT(0.001)QPPS(0.989)PAGAGMS(0.009)T(0.001)AMGR;VSEEQT(0.009)QPPS(0.991)PAGAGMSTAMGR;VSEEQTQPPS(1)PAGAGMSTAMGR 219.22 4.6745e-26 29688000.0 134129.0 106477.0 121361.0 110943.0 119577.0 87225.0 86702.0 96060.0 82902.0 99280.0 True False 126674.6471409292 114643.44352248283 113552.76538786582 95832.37201265011 104554.66822805675 99239.45200028546 90733.81479675365 96339.51869641097 99484.71647541727 96413.52843958187 1.3138679725875881 1.189080468041628 1.177767967065165 0.9939722522727094 1.0844398075688784 1.0293104464325715 0.9410900758975184 0.9992323718012532 1.0318543267271871 1.0 16.556947974586855 -4.8660607808715906 0.6668229118306827 0.9951739729694278 1.485924524631364 0.8570992708926892 0.04150048371891603 1.0287402552945795 0.3733300410456718 0.01913637079365564 0.37849445222064115 1.3612541573554678e-05 4.8660607808715906 0.49075055166193615 VSEFNVS(ph)SEGSGEK ddPTM_A459_Selumetinib_30min_R2 2 VSEFNVSSEGSGEK 14 0 Q9BVJ6-3;Q9BVJ6 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 1 VSEFNVS(0.797)S(0.203)EGSGEK;VSEFNVS(0.953)S(0.047)EGSGEK 137.73 0.00058461 8591700.0 24805.0 30392.0 24388.0 31203.0 28746.0 25410.0 25173.0 28157.0 19684.1 28951.0 True False 23426.43740228249 32722.96867431752 22818.902631646695 26953.09757182267 25134.670487499403 28909.99685098604 26343.594379353202 28238.93220835771 23621.470019707143 28115.10940626842 0.8332330158764893 1.1638926315905336 0.8116241805041347 0.9586694891471177 0.893991558926514 1.0282726072031716 0.9369906408217551 1.0044041373021184 0.8401699484207095 1.0 14.779058040498015 -10.116029312913941 6.156772175848192 0.9999995403128052 0.9473998466525572 0.026223121113616576 0.10134799846658225 1.3285440999090338e-10 3.6188603239589647e-26 0.09019156840479764 0.021874668416064773 7.655449343456542e-11 10.116029312913941 -0.05259969366024808 VSESEGKLEGQATAVT(ph)PNK ddPTM_A459_Selumetinib_30min_R2 1 VSESEGKLEGQATAVTPNK 19 1 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 1 VSESEGKLEGQAT(0.06)AVT(0.94)PNK 92.427 0.0031195 5597800.0 39340.0 36504.0 36745.0 37335.0 40679.0 34427.0 36362.0 32542.0 23591.0 40495.0 True False 37153.6402904976 39303.739421139995 34380.86670493102 32249.908593532673 35568.54034512587 39169.00675280976 38052.905049936075 32636.6918323819 28309.859187613907 39325.80413135435 0.9447649224513913 0.9994389253900402 0.8742571821314457 0.8200699084451757 0.9044580557417559 0.9960128627498407 0.9676319630447583 0.8299052633067651 0.7198799824424325 1.0 15.26318864562159 -7.776446687980271 24.7925149423686 0.8311693984216076 0.9274668581687021 0.15311452311875118 0.08220491480294091 356.1461973145246 588354.5960115361 0.045291481213497894 0.02189853699271811 1.6732210208116374e-08 7.776446687980271 0.09629745974709447 VSESPSPVTTNTPAQFASVSPT(ph)VPEFLK ddPTM_A459_Selumetinib_30min_R2 1 VSESPSPVTTNTPAQFASVSPTVPEFLK 28 0 Q9ULH7-4;Q9ULH7;Q9ULH7-5;I3L2S3;Q9ULH7-2;Q9ULH7-3 Q9ULH7-4 MKL2 MKL/myocardin-like protein 2;Phosphatase and actin regulator 1 VSESPS(0.001)PVT(0.001)T(0.001)NT(0.007)PAQFAS(0.297)VS(0.326)PT(0.365)VPEFLK 54.152 0.012604 3288900.0 18372.0 16882.0 18873.0 18582.0 20612.0 17226.0 16704.0 15795.0 13686.0 19795.0 True False 17350.957788943117 18176.795115814297 17658.7317273687 16051.099544262048 18022.536286382034 19598.72513794117 17480.76909834807 15840.960834996979 16423.582418790393 19223.46691641337 0.902592537776239 0.9455523915040838 0.918602862020239 0.8349742330067064 0.9375278853053317 1.0195208399795666 0.9093452900227196 0.8240428692636944 0.8543507001209869 1.0 14.230580926486592 -10.646756885182846 4.186559792290349 1.0000190283939732 0.9067380940539144 0.21161044356136183 0.05483817607216983 85325505.31769738 1.1154306089458805 16478.41813069234 0.014481954812026559 2.2555014717468205e-11 10.646756885182846 -0.0932809343400588 VSFELFADK ddPTM_A459_Selumetinib_30min_R2 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 120.99 0.041632 0.0 9228.2 7600.4 8276.5 10511.0 10273.0 8150.4 8402.7 8929.9 8130.7 8109.3 False True 8715.333587411544 8183.326240862158 7743.999000771852 9079.383667513639 8982.413898214752 9273.043618035284 8793.442199634183 8955.88453057547 9757.067190739368 7875.163438508259 1.1066860587038727 1.039130972297925 0.9833445440516149 1.152913680891617 1.140600314946128 1.1775049102716548 1.1166044067905552 1.1372315762721394 1.2389669455022239 1.0 12.943094149683091 -5.780496779715676 24.96919006128685 1.1443086359359906 1.0426615673076405 0.3193901462679499 0.06278749733711998 240.6761381106694 315335.3081757438 0.016852542538168078 0.02504062127045698 1.657689628536561e-06 5.780496779715676 -0.10164706862835016 VSFELFADKVPK ddPTM_A459_Selumetinib_30min_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 118.87 0.012447 11917000.0 4618.9 4768.6 6495.3 6678.9 5037.4 4700.6 4734.9 5009.5 3533.1 3783.8 False True 4726.511383185123 4210.2900951380025 5613.273936129013 5512.555493480444 4581.768059425203 4653.31623180332 4377.742680910137 4876.631786850716 5995.412652585741 4269.487587333127 1.1070441795422739 0.9861347548191138 1.3147418329034803 1.2911515447041695 1.073142377323818 1.0899004006028616 1.0253555236694412 1.14220540219367 1.4042464183226935 1.0 12.05984721643447 -8.030850533307492 24.99044457974098 1.2258241066487785 1.1280372428522283 0.04103272024155091 0.134120972681981 1905.1212442253614 1543229.558763898 0.09079544029806796 0.03441257962820955 9.31428380496916e-09 8.030850533307492 -0.09778686379655022 VSFELFADKVPK ddPTM_A459_Selumetinib_30min_R2 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 116.74 0.0060899 0.0 14817.0 13142.0 20992.0 20649.0 17725.0 13990.0 16030.0 12130.0 13863.0 18412.0 False True 13993.530457150564 14149.949141809715 19641.397574361472 17836.570578488172 15498.227036489501 15916.99551142442 16775.42676284241 12165.296291770403 16635.9873645836 17880.3977198789 0.7826185231659007 0.7913665771583044 1.0984877340018417 0.997548872118096 0.8667719409428476 0.8901924756253253 0.938202104094809 0.680370564590148 0.9304036534986132 1.0 14.126091206793019 VSFPSYLAS(ph)PAGSR ddPTM_A459_Selumetinib_30min_R2 1 VSFPSYLASPAGSR 14 0 Q96PE2 Q96PE2 ARHGEF17 Rho guanine nucleotide exchange factor 17 1 VSFPSYLAS(0.989)PAGS(0.01)R 121.92 0.0018495 3133300.0 8697.7 8036.2 13076.0 12324.0 10452.0 8387.9 8024.1 7286.9 6465.0 10897.0 True False 8214.316653651782 8652.550699544301 12234.704396072348 10645.449939914193 9138.926317934453 9543.257087224942 8397.236549452507 7308.103672588764 7758.18064719274 10582.375296193812 0.7762261707545228 0.8176378608171632 1.1561397185065656 1.0059603484052457 0.8635987726896694 0.9018067135322055 0.7935115051601659 0.6905919954679067 0.7331228037228223 1.0 13.369375867438213 -7.113422276393716 2.122023701714898 0.7767120243590098 0.9363155360426465 0.15666398697868922 0.12540319153060073 0.5085060906779767 4.506797836485186 0.060328772004393294 0.04349896077275967 7.701542628490771e-08 7.113422276393716 0.15960351168363673 VSGAGFS(ph)PSSK ddPTM_A459_Selumetinib_30min_R1 3 VSGAGFSPSSK 11 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VSGAGFS(0.98)PS(0.019)S(0.001)K;VSGAGFS(0.994)PS(0.006)SK;VSGAGFS(0.936)PS(0.062)S(0.002)K 183.06 3.2938e-05 121670000.0 18634.1 20616.0 22952.699999999997 23078.699999999997 18420.8 16820.6 18860.8 17598.4 10484.2 15353.2 True False 19068.23827435318 18202.26913588161 19835.849410156312 19048.438285853506 16754.641892456395 16651.400035882845 17438.114671082796 17131.633264340493 17790.921664328613 17323.932772832322 1.1006876166280388 1.0507007487599298 1.14499690516366 1.0995446897442123 0.9671384732415552 0.961178980213768 1.0065909917654228 0.988899777492014 1.0269562862901795 1.0 14.080478858563204 -6.2540370352768075 24.81791009019152 0.9904481632833181 1.0988205462241443 0.7852315399701081 0.027457017844154878 238.2322172990326 798723.6912333794 0.008403068887937614 0.010635469960700143 5.57138235897657e-07 6.2540370352768075 0.10837238294082618 VSGAGFS(ph)PSSK ddPTM_A459_Selumetinib_30min_R2 5 VSGAGFSPSSK 11 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VS(0.001)GAGFS(0.968)PS(0.024)S(0.007)K;VSGAGFS(0.996)PS(0.003)S(0.001)K;VSGAGFS(0.785)PS(0.206)S(0.009)K;VS(0.005)GAGFS(0.959)PS(0.018)S(0.018)K;VS(0.001)GAGFS(0.989)PS(0.01)SK 156.52 0.00054829 272399600.0 1305878.0 1177454.0 1421732.0 1337614.0 1428119.0 1092049.0 1147895.0 1279031.0 1026892.0 1396217.0 True False 1233302.5286038232 1267760.9356886623 1330259.3109847587 1155428.6656871447 1248705.9236741513 1242468.8371161923 1201274.3920107915 1282752.7684550206 1232299.0937597929 1355904.587402574 0.9095791400532007 0.9349927328715929 0.9810862234289343 0.8521459964233404 0.9209393752891 0.9163394302664881 0.8859579082271575 0.9460494347263136 0.9088390917833202 1.0 20.370824231482672 -10.603741591090936 4.957607779751635 1.0000022810503508 0.917802914718615 0.3675183250349404 0.03253156624505177 8.108537554419613e-07 1.5032217918765155e-07 0.0311399224164106 0.0075523309999464255 2.4903386502056467e-11 10.603741591090936 -0.08219936633173586 VSGAGFSPS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 VSGAGFSPSSK 11 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 VSGAGFS(0.017)PS(0.902)S(0.081)K 168.83 0.00045652 70887000.0 4192.1 5186.8 5571.2 6099.2 5448.2 4781.1 5557.2 5281.3 3025.5 4299.7 True False 4289.767773593356 4579.5270447221 4814.661640411057 5034.089216163725 4955.411271957835 4733.0064748914665 5138.015929872614 5141.2227679198895 5134.052526222908 4851.608377624677 0.8841949802415018 0.9439193538049362 0.992384641476007 1.0376124419647386 1.0213955633376945 0.9755541062876808 1.0590335266071416 1.0596945111297311 1.0582166008907163 1.0 12.244247385313985 -3.7533913354605364 0.6194854793369912 1.0381771433724722 0.4103875645716455 0.7689580139896519 0.026071116589541105 5.273597773331378 0.586118512057398 0.012456210658132029 3.142817861454453 0.00017644471904320046 3.7533913354605364 -0.6277895788008268 VSGEEELHTGPPAPQGPLSVPQGLPTQSLAS(ph)PPAR ddPTM_A459_Selumetinib_30min_R1 2 VSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPAR 35 0 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 VSGEEELHTGPPAPQGPLSVPQGLPT(0.01)QS(0.023)LAS(0.967)PPAR;VSGEEELHTGPPAPQGPLS(0.008)VPQGLPT(0.034)QS(0.034)LAS(0.924)PPAR 120.59 1.7596e-19 54520000.0 2369.39 2395.06 2976.0600000000004 3234.58 2736.7400000000002 2268.3199999999997 2191.45 2509.13 1501.54 1932.73 True False 2424.592176969626 2114.6452617668147 2571.9273983274206 2669.7213235865133 2489.2023502106917 2245.5027602697733 2026.1471621534827 2442.5797215971147 2548.0037118574583 2180.8147218844433 1.11178274460406 0.9696583760859558 1.1793424597322126 1.2241852995561244 1.141409366523246 1.0296623265315419 0.9290780834433692 1.1200308293436685 1.168372391422471 1.0 11.090651491058525 -6.759845943186011 24.9662226527839 1.0494087342212084 1.1251289424632371 0.1630628031917556 0.08591622941262607 90.42502813647641 1416802.7140160187 0.03182491825477241 0.030232693003704847 1.738417386315315e-07 6.759845943186011 0.07572020824202874 VSGEEELHTGPPAPQGPLSVPQGLPTQSLAS(ph)PPAR ddPTM_A459_Selumetinib_30min_R2 2 VSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPAR 35 0 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 VSGEEELHTGPPAPQGPLSVPQGLPT(0.016)QS(0.003)LAS(0.981)PPAR;VSGEEELHTGPPAPQGPLSVPQGLPT(0.042)QS(0.059)LAS(0.899)PPAR 115.41 3.9423999999999996e-19 24449000.0 25475.2 26101.0 31719.0 38183.0 33236.0 29217.0 30728.0 30029.0 26354.0 38181.0 True False 24059.39036930567 28102.86277205715 29678.23407303598 32982.40953065106 29060.596546390127 33241.376544480874 32156.912886376896 30116.379418431443 31625.5363922842 37078.61532384839 0.6488751038615793 0.757926436211382 0.8004137644791552 0.8895264626949886 0.783756251213049 0.896510731432318 0.8672630465165745 0.8122304232612768 0.8529319694401627 1.0 15.178299748035077 -3.78129755956171 0.6471010909356879 0.8698674616145513 1.1597377195256435e-18 0.6334396297852969 0.05418725452822675 6.905862036542703 0.8279543117454857 0.022340126017521632 5.967452407364753 0.00016546358909477318 3.78129755956171 -0.8698674616145513 VSGS(ph)PEQAVEENLSSYSLDR ddPTM_A459_Selumetinib_30min_R2 2 VSGSPEQAVEENLSSYSLDR 20 0 A0A494BZT8;Q9Y6A5;E7EMT0;C9JA91 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 VS(0.29)GS(0.71)PEQAVEENLSSYSLDR;VS(0.026)GS(0.974)PEQAVEENLSSYSLDR 118.23 0.00098857 3410900.0 10884.8 8003.5 12531.7 10952.5 12842.4 11587.8 12096.599999999999 13311.2 12644.2 9908.3 True False 10279.866391306772 8617.342714691375 11725.42406548331 9460.75060588366 11229.02289948731 13183.914266424872 12659.11586895816 13349.933388212217 15173.393308466266 9622.221634144913 1.0683464569999277 0.8955668495633402 1.21857763324377 0.9832189452290035 1.1669885943637577 1.370152836600762 1.3156125841080903 1.3874065570095935 1.5769116411352193 1.0 13.232154314886548 -6.593160635650758 3.2353259097196423 1.35397872152986 1.0443195248628752 0.43581521050261995 0.15355140459161407 0.2152903385663379 4.5621066724798975 0.05097065225340347 0.051883447447017284 2.5517572911059593e-07 6.593160635650758 -0.3096591966669848 VSGS(ph)PEQAVEENLSSYSLDRR ddPTM_A459_Selumetinib_30min_R1 2 VSGSPEQAVEENLSSYSLDRR 21 1 A0A494BZT8;Q9Y6A5;E7EMT0;C9JA91 A0A494BZT8 TACC3 Transforming acidic coiled-coil-containing protein 3 1 VS(0.046)GS(0.954)PEQAVEENLSSYSLDRR;VS(0.049)GS(0.951)PEQAVEENLSSYSLDRR 170.68 1.0079e-10 45584000.0 1552.19 1616.7 2203.1000000000004 1874.52 2069.37 1838.6799999999998 2077.63 2044.6000000000001 1054.1399999999999 1428.1799999999998 True False 1588.3530069640208 1427.4160124165612 1903.9311207620628 1547.1702710983786 1882.1958488769467 1820.1845485878664 1920.9126963904898 1990.3705662032096 1788.7985886605895 1611.5008146512564 0.9856358696956383 0.885768098556914 1.1814645723117994 0.9600803530671503 1.167976976346904 1.1294965115992022 1.1920023117122611 1.2351036674058053 1.1100202819616334 1.0 10.65418920237573 -5.453246249677918 0.841861005421626 1.1524584358064882 0.9089968634126105 0.3298884312765149 0.09158597547866203 1.1047037808743803 1.1400782749819525 0.036329118311159016 0.20924890375806654 3.5217112957291676e-06 5.453246249677918 -0.24346157239387767 VSGTLDT(ph)PEK ddPTM_A459_Selumetinib_30min_R1 1 VSGTLDTPEK 10 0 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 VS(0.001)GT(0.136)LDT(0.863)PEK 142.76 0.0027216 43712000.0 4367.8 6405.8 3330.0 3357.5 3575.5 3986.7 4235.0 4052.1 2216.5 4584.0 True False 4469.561241740672 5655.80595802437 2877.8042903806763 2771.1756530806842 3252.0966563057946 3946.59741763398 3915.5505403819366 3944.6251449242004 3761.238613245105 5172.401051941188 0.8641173019758895 1.0934585120582947 0.5563768666585984 0.5357619460000438 0.6287402356561836 0.7630107135936092 0.7570083025391934 0.7626294065971149 0.7271745898036122 1.0 12.336618426247774 -9.639337668696754 16.291756980897684 0.9999999996946299 0.7400534673014428 0.2052126968928315 0.15153869330581132 0.0 0.0 0.1601631641031602 0.03884527311355674 2.2943640613509123e-10 9.639337668696754 -0.2599465323931871 VSGTLDT(ph)PEK ddPTM_A459_Selumetinib_30min_R2 4 VSGTLDTPEK 10 0 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 VSGT(0.001)LDT(0.999)PEK;VSGTLDT(1)PEK;VSGT(0.002)LDT(0.998)PEK;VSGTLDT(1)PEK 174.46 0.00019385 225995000.0 1413935.0 1219636.0 1225892.0 1257152.0 1266575.0 1268065.0 1469066.0 1418005.0 1191856.0 1267696.0 True False 1335354.1531302677 1313178.1594521531 1147019.443370288 1085925.7288918404 1107456.5251758364 1442729.4434020321 1537380.4798990532 1422131.159786636 1430260.5032390645 1231094.3226102348 1.084688742856823 1.066675505957886 0.9317071992812975 0.8820816642135105 0.8995708166598846 1.1719081283252746 1.2487917876506922 1.155176442347126 1.161779789713063 1.0 20.231509870178982 -6.773207075289068 24.998569356392306 1.1635585905672243 0.9708131214685557 0.5140690806627792 0.08413948916516094 178.42271135519735 379027.9369011499 0.03129966080814872 0.027822823797660184 1.6857490543001786e-07 6.773207075289068 -0.19274546909866863 VSGTLDT(ph)PEKTVDSQGPTPVCTPTFLER ddPTM_A459_Selumetinib_30min_R1 1 VSGTLDTPEKTVDSQGPTPVCTPTFLER 28 1 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 VSGT(0.001)LDT(0.696)PEKT(0.303)VDSQGPTPVCTPTFLER 142.56 8.937200000000001e-13 133420000.0 1271.5 1461.7 1847.6 1688.9 1408.0 1403.3 1333.3 1545.2 789.74 1135.2 True False 1301.1234760916861 1290.5634844741055 1596.7060681403402 1393.9653195794397 1280.6466486025893 1389.1840760944547 1232.728107554011 1504.2162764830284 1340.1310996725422 1280.9139777843873 1.015777404773313 1.0075332979864964 1.246536532376813 1.0882583403380441 0.999791298099299 1.0845256591682633 0.9623816500826045 1.1743304410534188 1.0462303659068375 1.0 10.322957876664058 -6.029294062193867 23.509426425619928 1.0505029735153735 1.0959891342185921 0.0640169341527338 0.08143678998463164 1051.9062758184068 844187.4333044031 0.024511489117284242 0.031714086849844864 9.347725223285869e-07 6.029294062193867 0.04548616070321865 VSGTLDT(ph)PEKTVDSQGPTPVCTPTFLER ddPTM_A459_Selumetinib_30min_R2 2 VSGTLDTPEKTVDSQGPTPVCTPTFLER 28 1 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 VSGT(0.002)LDT(0.499)PEKT(0.499)VDSQGPTPVCTPTFLER;VS(0.001)GT(0.012)LDT(0.785)PEKT(0.202)VDSQGPTPVCTPTFLER 87.792 3.3812e-05 89932000.0 66486.0 75933.0 73054.0 77030.0 76941.0 56110.0 54150.0 52239.0 43830.0 75576.0 True False 62790.974284545635 81756.81693692262 68353.78517518112 66538.38111583819 67274.98371873278 63838.64318413322 56668.0822961894 52391.006841368006 52597.22471252249 73393.9245099702 0.8555336794398534 1.113945295646595 0.9313275673914345 0.9065924946798462 0.9166287832120737 0.8698082792324461 0.7721086271724211 0.7138330208006652 0.7166427611508555 1.0 16.163373022425702 -6.781982725269759 1.3405121161703615 0.7770631012193315 0.9670237160100531 0.3119017869150019 0.09830826118556879 0.4268560301597548 1.6052197850891872 0.04585519399580902 0.040642238409500236 1.6520275088543734e-07 6.781982725269759 0.18996061479072157 VSGTLDTPEKT(ph)VDSQGPTPVCTPTFLER ddPTM_A459_Selumetinib_30min_R1 2 VSGTLDTPEKTVDSQGPTPVCTPTFLER 28 1 H7BZL0;Q9BYG3;C9J808 H7BZL0 NIFK MKI67 FHA domain-interacting nucleolar phosphoprotein 1 VSGT(0.001)LDT(0.199)PEKT(0.795)VDS(0.006)QGPTPVCTPTFLER;VSGTLDT(0.055)PEKT(0.859)VDS(0.083)QGPT(0.003)PVCTPTFLER 148.58 5.8253e-14 89958900.0 2077.51 2888.9 3160.1000000000004 2818.5 2298.55 2541.56 2258.29 2096.35 1458.1799999999998 1992.25 True False 2125.9119408692395 2550.6662449868263 2730.9757771867808 2326.3018847975914 2090.646558341964 2515.9942139518434 2087.9453671402907 2040.7479880955186 2474.4249587465597 2247.9746936583397 0.9457010111664309 1.134650782405334 1.2148605519853108 1.0348434487986973 0.9300133868231671 1.119227107426788 0.9288117757866667 0.9078162640587463 1.1007352376906416 1.0 11.134410079322743 -5.990122977355873 24.92162450983151 0.9945692332083815 1.105832670929583 0.19790983654142846 0.09012080135098915 296.32669936034563 747681.2112698643 0.02529909169356445 0.03747412969560792 1.0230032716963565e-06 5.990122977355873 0.1112634377212014 VSHEQFR ddPTM_A459_Selumetinib_30min_R2 2 VSHEQFR 7 0 O96013;O96013-2;O96013-4;O96013-3;Q9P286 O96013 PAK4;PAK7 Serine/threonine-protein kinase PAK 4;Serine/threonine-protein kinase PAK 7 0 ; 192.28 2.0016e-29 4500900.0 17177.9 14533.3 13523.4 17960.5 19758.8 11641.599999999999 17120.3 16033.7 16531.4 19197.6 False True 16223.22108658208 15647.957378075098 12653.319167164636 15514.248916409355 17276.522898086805 13245.124728077091 17916.42787323086 16080.355412478073 19838.14192590905 18643.315406644964 0.8701897024603092 0.839333403783844 0.6787054175275425 0.8321614786863324 0.9266872614260981 0.7104489968214658 0.9610108225088 0.8625265979647919 1.0640887360001547 1.0 14.186370821912908 -7.858037340074111 1.2459651445358417 1.0244807305672945 0.8122468473405674 0.48115433990747813 0.0822356163846621 0.4059365905053475 1.1372242093213951 0.07041816070299643 0.025924182267509064 1.3866366025367886e-08 7.858037340074111 -0.2122338832267271 VSHYIINSSGPRPPVPPS(ph)PAQPPPGVSPSR ddPTM_A459_Selumetinib_30min_R2 2 VSHYIINSSGPRPPVPPSPAQPPPGVSPSR 30 1 P46108-2;I3L297;P46108 P46108-2;P46108 CRK Adapter molecule crk 1 VS(0.001)HY(0.001)IINS(0.031)S(0.031)GPRPPVPPS(0.816)PAQPPPGVS(0.081)PS(0.039)R;VSHYIINS(0.002)S(0.003)GPRPPVPPS(0.94)PAQPPPGVS(0.042)PS(0.013)R 86.99700000000001 8.539399999999998e-07 15756700.0 17673.9 20711.7 20925.1 24271.0 25049.0 19557.7 18821.5 17752.9 20594.0 20373.8 True False 16691.6553922274 22300.22079138794 19578.801847526254 20965.247930189675 21902.120679098738 22251.595647876005 19696.737044094716 17804.5579998492 24713.37544443733 19785.55545651037 0.8436283443705427 1.1270960191340056 0.9895502752278766 1.0596239249523385 1.1069752743227594 1.1246384109248848 0.9955109467302607 0.8998765811242702 1.2490614933080122 1.0 14.272159947417773 -4.749649851309011 24.988197666952683 1.057286690975991 0.8436278638671272 0.33311096280493246 0.09226363208745743 638.3014088448228 1352811.2709715194 0.022104837919009135 0.35256843603712706 1.7797137208830255e-05 4.749649851309011 -0.21365882710886386 VSHYIINSSGPRPPVPPSPAQPPPGVS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 VSHYIINSSGPRPPVPPSPAQPPPGVSPSR 30 1 P46108-2;I3L297;P46108 P46108-2;P46108 CRK Adapter molecule crk 1 VSHY(0.001)IINS(0.002)S(0.002)GPRPPVPPS(0.279)PAQPPPGVS(0.551)PS(0.166)R 50.604 0.0079515 28921000.0 1639.3 1805.0 1668.9 1442.3 1617.4 1633.4 1590.2 1337.8 704.7 1282.8 True False 1677.4925004774684 1593.6697608782663 1442.2725466115044 1190.4293803241314 1471.1064555751634 1616.9694790085384 1470.2499337226357 1302.317198213173 1195.8244307484 1447.4598755301374 1.1589215900462047 1.1010113563905037 0.996416253737788 0.8224265145091724 1.0163366048653786 1.117108326347435 1.0157448635211055 0.8997259407527235 0.8261537683802288 1.0 10.499307641045153 -5.222325693090652 3.1286148755945864 0.9611159947655865 1.1448073067570883 0.39030651732385424 0.0859968853045461 0.2904175740008286 5.678244170873758 0.025135009844057157 0.07808765446493386 5.993414399220245e-06 5.222325693090652 0.1836913119915018 VSIGNITLS(ph)PAISR ddPTM_A459_Selumetinib_30min_R1 2 VSIGNITLSPAISR 14 0 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 VSIGNIT(0.001)LS(0.999)PAISR;VSIGNITLS(1)PAISR 252.01 1.2815999999999999e-27 283300000.0 4201.1 5009.200000000001 3613.0 4456.9 4137.4 3588.2 4763.8 4808.5 2397.8 4466.0 True False 4298.977456082406 4422.720535286099 3122.374444788401 3678.5860813746217 3763.172900517296 3552.105965824931 4404.462730642617 4680.962959790735 4068.891471617019 5039.254602523849 0.8530978875187842 0.8776537174904864 0.6196103771428016 0.7299861530179973 0.7467717345800621 0.7048871799503645 0.8740306013585216 0.9288998728991252 0.8074391537151475 1.0 12.298994633313342 -7.378347528372387 5.241194279369224 0.9008290334271741 0.7535375806653208 0.444241873552944 0.08108247075244623 0.23871434586499846 9.340006765100608 0.03615868383037631 0.023968651896109146 4.1845857484049664e-08 7.378347528372387 -0.1472914527618533 VSIGNITLS(ph)PAISR ddPTM_A459_Selumetinib_30min_R2 2 VSIGNITLSPAISR 14 0 Q0JRZ9-3;Q0JRZ9 Q0JRZ9-3 FCHO2 F-BAR domain only protein 2 1 VSIGNIT(0.01)LS(0.99)PAISR;VSIGNIT(0.002)LS(0.99)PAIS(0.008)R 170.0 0.00016738 173989000.0 76063.0 51932.0 70761.0 67118.0 84480.0 53272.0 68049.0 56813.0 53471.0 52220.0 True False 71835.72296431425 55915.01741230119 66208.31429875168 57976.41261499195 73866.86713921763 60609.73444493225 71213.41333653551 56978.316424101555 64166.69410456972 50712.2729161458 1.4165352652028964 1.1025933999203363 1.305567873248928 1.1432422425801663 1.4565875850478764 1.1951689593000927 1.4042638840954522 1.1235606914783103 1.265308975810869 1.0 15.630047316769337 -9.15564490809813 0.869695880674103 0.9985513917606184 1.2735078261133388 0.3122251716230333 0.12057761891681103 2.851459514210363 2.9371081073159626 0.12098487734975892 0.03652666367988995 6.988035328168243e-10 9.15564490809813 0.27495643435272044 VSISEGDDKIEYR ddPTM_A459_Selumetinib_30min_R2 2 VSISEGDDKIEYR 13 1 M0R2U2;M0R1H0;M0R2B0;M0R0P1;M0QXL5;M0R2Q4;P22087;M0R299 M0R2U2 FBL rRNA 2-O-methyltransferase fibrillarin 0 ; 113.95 0.012385 13201000.0 108707.0 100755.0 110618.0 113801.0 107987.0 83146.0 97198.0 90330.0 73639.0 100289.0 False True 102665.50012860003 108482.58452161292 103500.95831177215 98301.10748232524 94420.7076439713 94598.60677576085 101717.89959418324 90592.8453450634 88368.85764557245 97393.39598788467 1.0541320495834359 1.1138597583670633 1.0627102306263891 1.0093200517882495 0.9694775162755064 0.9713041199172121 1.0444024316272587 0.9301744171271404 0.9073393195629524 1.0 16.5715363294901 -5.849191902769945 2.1712887622275088 0.9706366787364743 1.0856195996856173 0.6223565418738752 0.03723275456176422 0.20777885846244062 1.9974496754005295 0.011969899102890902 0.0211562995524715 1.4151683178777982e-06 5.849191902769945 0.11498292094914297 VSITEAMHR ddPTM_A459_Selumetinib_30min_R2 1 VSITEAMHR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-6;Q15149-3;Q15149-2;H0YDN1;Q15149-4 Q15149;Q15149-3;Q15149-4 PLEC Plectin 0 161.27 0.0012947000000000002 1673600.0 12453.0 9103.1 12007.0 15792.0 16634.0 14454.0 9124.7 8380.7 9585.8 12365.0 False True 11760.912113308761 9801.278498920099 11234.482692233138 13641.102357280504 14544.28821015325 16444.907299651783 9549.01663025004 8405.086449500426 11503.227849630342 12007.990321871755 0.9794238501247825 0.8162297133990625 0.9355839229625522 1.1360021112303984 1.2112175160286227 1.369497048119574 0.7952218792895879 0.6999577967839564 0.9579644504441329 1.0 13.551707098846434 VSKS(ph)PSPASTSTVPNMTDAPTAPK ddPTM_A459_Selumetinib_30min_R1 1 VSKSPSPASTSTVPNMTDAPTAPK 24 1 Q659A1 Q659A1 ICE2 Little elongation complex subunit 2 1 VS(0.202)KS(0.683)PS(0.088)PAS(0.008)T(0.008)S(0.008)T(0.002)VPNMTDAPTAPK 97.366 5.0313e-06 19158000.0 3830.9 3858.7 5293.8 5398.8 4649.9 4154.8 4391.6 3847.0 2283.6 3447.8 True False 3920.1525163662122 3406.9216101390366 4574.931036761931 4456.000928027401 4229.317366006522 4113.006484256565 4060.338076302558 3744.965063182895 3875.10241245501 3890.3587144159733 1.0076583688388003 0.8757345685153584 1.1759663754936611 1.1453959018008812 1.0871278656989949 1.0572306530540632 1.043692464979313 0.9626271863583394 0.9960784331006727 1.0 11.92568747114586 -7.639484130156061 5.080230655953901 0.9849923200411992 1.0597484580618817 0.14927765526884484 0.07685771038311429 0.4409738244032856 17.704731512838926 0.04128356436686975 0.023115470594891427 2.2935904405323063e-08 7.639484130156061 0.07475613802068248 VSKSPS(ph)PASTSTVPNMTDAPTAPK ddPTM_A459_Selumetinib_30min_R2 1 VSKSPSPASTSTVPNMTDAPTAPK 24 1 Q659A1 Q659A1 ICE2 Little elongation complex subunit 2 1 VS(0.206)KS(0.206)PS(0.278)PAS(0.098)T(0.098)S(0.098)T(0.015)VPNMTDAPTAPK 88.39399999999998 4.153e-05 17624000.0 103540.0 88502.0 103620.0 108530.0 98215.0 76377.0 88225.0 79779.0 68702.0 88221.0 True False 97785.66130346009 95289.81882121769 96953.20201292586 93748.02677530752 85876.35364675974 86897.23846862496 92327.63731452095 80011.14368187556 82444.31969426683 85673.8305043143 1.1413714167774471 1.1122395048791376 1.1316548056998987 1.0942434372720924 1.002363885695939 1.0142798326759657 1.077664401965447 0.9339041246421965 0.9623045824957617 1.0 16.38656697283441 -6.264673962578652 0.6808663851530801 0.9763524822041856 1.1496411828630662 0.7321124130052734 0.036133073673814596 0.45462774233382636 0.4503616462538973 0.02428417985487644 0.044789179282082786 5.436583183441628e-07 6.264673962578652 0.17328870065888058 VSKSPSPAS(ph)TSTVPNMTDAPTAPK ddPTM_A459_Selumetinib_30min_R2 1 VSKSPSPASTSTVPNMTDAPTAPK 24 1 Q659A1 Q659A1 ICE2 Little elongation complex subunit 2 1 VS(0.079)KS(0.079)PS(0.037)PAS(0.259)T(0.259)S(0.259)T(0.029)VPNMTDAPTAPK 108.19 2.6653000000000004e-07 20434000.0 112110.0 108800.0 135470.0 143390.0 130330.0 101990.0 99122.0 103200.0 84041.0 119090.0 True False 105879.37501188843 117144.6101528605 126754.0076885835 123860.03463845311 113956.78023501707 116038.1967269605 103731.36940651694 103500.2949143202 100851.5483017364 115651.56226702026 0.9155031971589846 1.0129098808228205 1.0959990959389683 1.0709758883540272 0.9853457921468435 1.0033430975973119 0.8969301181337994 0.8949320950404042 0.8720292776407716 1.0 16.819425229037456 -7.168470347047355 3.3096815609268027 0.9066151243284712 1.0218218785802684 0.42099727254336416 0.05564255883617145 0.2354974635026989 4.920550642887518 0.0240282999033296 0.017774563244598345 6.7846844368829e-08 7.168470347047355 0.11520675425179716 VSLEPHQGPGT(ph)PESK ddPTM_A459_Selumetinib_30min_R1 4 VSLEPHQGPGTPESK 15 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 VSLEPHQGPGT(1)PESK;VSLEPHQGPGT(0.996)PES(0.004)K;VSLEPHQGPGT(0.985)PES(0.015)K;VSLEPHQGPGT(0.99)PES(0.01)K 194.32 4.9258e-05 167054800.0 10526.0 12199.3 11330.400000000001 12842.099999999999 13365.9 10801.900000000001 13816.900000000001 10193.6 3390.51 7498.6 True False 10771.235319969393 10771.000284699294 9791.793913432199 10599.46831107296 12156.9567049413 10693.242693340484 12774.680108949993 9923.232614520708 5753.44783694729 8461.118352549334 1.2730273790253768 1.2729996007506492 1.1572694655053408 1.252726633693682 1.4368025831098805 1.2638096109503787 1.5098098828863424 1.1728039014524407 0.6799866870097351 1.0 13.046632649549093 -8.085113761138436 5.346133734989305 0.850892126846224 1.3058351807314124 0.7095847165926832 0.11837624481178512 0.11792787755783003 5.491442320876553 0.08168552170397245 0.030019175908261038 8.220272960481882e-09 8.085113761138436 0.4549430538851884 VSLEPHQGPGT(ph)PESK ddPTM_A459_Selumetinib_30min_R2 4 VSLEPHQGPGTPESK 15 0 A0A087WY61;Q14980-2;Q14980;Q14980-5;H0YFY6 A0A087WY61 NUMA1 Nuclear mitotic apparatus protein 1 1 VSLEPHQGPGT(0.983)PES(0.017)K;VSLEPHQGPGT(1)PESK;VSLEPHQGPGT(0.975)PES(0.025)K;VSLEPHQGPGT(0.974)PES(0.026)K 165.24 0.00020508 371082000.0 316454.0 265628.0 364214.0 422536.0 413860.0 295175.0 262158.0 296349.0 268675.0 365208.0 True False 298866.7535457328 286000.81347136066 340780.86776621983 364985.8678847438 361867.2068446569 335832.6769181343 274348.86645622214 297211.32652678236 322417.50740673055 354663.49611566035 0.8426769510225223 0.8064004799019183 0.9608569009737805 1.0291046918618239 1.020311396035659 0.9469051103263668 0.7735469521417943 0.8380093519121514 0.9090800461223278 1.0 18.436091322378232 -10.230914143318294 15.145465409751447 1.0000000393374577 0.9045826624720155 0.10914005460639697 0.08303704154868483 0.0 0.0 0.09154927485305915 0.022203960598109748 5.876055061411283e-11 10.230914143318294 -0.09541737686544227 VSLLGPVT(ph)TPEHQLLK ddPTM_A459_Selumetinib_30min_R1 2 VSLLGPVTTPEHQLLK 16 0 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 VSLLGPVT(0.919)T(0.081)PEHQLLK;VSLLGPVT(0.942)T(0.058)PEHQLLK 171.25 1.1226e-05 41669000.0 11934.400000000001 16044.7 17163.1 18892.7 16555.4 13710.6 14382.9 12003.2 7122.9 10735.5 True False 12212.448299700054 14166.179065021335 14832.44529015994 15593.444604901704 15057.966993093265 13572.683812228774 13297.986273260778 11684.836144111498 12087.04106396733 12113.50599762535 1.008167932726834 1.1694532588499462 1.224455190187514 1.287277573310199 1.243072566773412 1.1204587519822478 1.0977817880197216 0.9646122391322639 0.9978152540095981 1.0 13.564328862528761 -7.4255404845836255 1.869269931223386 0.9849896108658137 1.1902423020154786 0.5755250808752789 0.07202277685598488 0.26518905412766125 1.8096201981920066 0.04487960728408006 0.02454134157663694 3.753699611540704e-08 7.4255404845836255 0.20525269114966493 VSLLGPVT(ph)TPEHQLLK ddPTM_A459_Selumetinib_30min_R2 2 VSLLGPVTTPEHQLLK 16 0 Q9H0H5 Q9H0H5 RACGAP1 Rac GTPase-activating protein 1 1 VSLLGPVT(0.693)T(0.307)PEHQLLK;VSLLGPVT(0.945)T(0.055)PEHQLLK 127.88 0.0013566 7061700.0 72994.0 74788.0 80905.0 79964.0 87147.0 69078.0 60962.0 71454.0 59848.0 87808.0 True False 68937.28569813377 80523.99911867779 75699.6603827036 69072.76525440591 76198.8147559351 78592.86747234987 63796.85379391134 71661.91931015348 71819.2722928371 85272.75488741742 0.8084327261286351 0.9443109844989851 0.887735601865416 0.8100215050586816 0.8935892226835838 0.9216644586669356 0.7481504951744558 0.8403847090992446 0.842229999343372 1.0 16.379797245741948 VSLPS(ph)SPVPASPASSSGADQR ddPTM_A459_Selumetinib_30min_R1 1 VSLPSSPVPASPASSSGADQR 21 0 Q5T6S3-2 Q5T6S3-2 1 VSLPS(0.816)S(0.184)PVPASPASSSGADQR 244.27 1.4905e-31 5898500.0 1153.1 1651.0 1547.8 1184.2 1534.6 1103.5 1580.0 1370.8 790.42 902.76 True False 1179.9649864579799 1457.7001524709233 1337.6172614568202 977.401700187087 1395.7957009556353 1092.3997918978343 1460.8193279347026 1334.4419310140663 1341.2850100073072 1018.6380396270562 1.1583751446097466 1.4310285849963118 1.3131428529279632 0.9595181626487593 1.3702568004103441 1.0724121320835258 1.4340906888471767 1.3100256215668447 1.316743492613312 1.0 9.992425783464714 -5.595114960489999 24.999999920480594 1.2249460939252133 1.31413884809798 0.05538277844788142 0.16210088738620643 131.1221853578894 45376.36747294665 0.042834200135451396 0.07419100090903712 2.540300183053598e-06 5.595114960489999 0.08919275417276684 VSLPSS(ph)PVPASPASSSGADQR ddPTM_A459_Selumetinib_30min_R1 1 VSLPSSPVPASPASSSGADQR 21 0 Q5T6S3-2 Q5T6S3-2 1 VSLPS(0.136)S(0.863)PVPASPASSSGADQR 250.1 6.0361e-39 6707900.0 776.22 943.31 1100.5 869.54 869.01 909.29 1074.1 797.01 479.28 674.14 True False 794.3044157388036 832.866826667079 951.0581446137943 717.6911622873502 790.4081989361771 900.1433681692632 993.0797722371284 775.870705746659 813.3031547737944 760.6724356796748 1.0442134859653198 1.094908646088769 1.2502860627045154 0.9434956870049852 1.0390914168329668 1.1833521578377801 1.3055288001198484 1.0199800457517623 1.0691897282265699 1.0 9.571131517147144 VSLPSS(ph)PVPASPASSSGADQR ddPTM_A459_Selumetinib_30min_R2 2 VSLPSSPVPASPASSSGADQR 21 0 Q5T6S3-2 Q5T6S3-2 1 VSLPS(0.026)S(0.974)PVPASPASSSGADQR;VS(0.001)LPS(0.063)S(0.934)PVPAS(0.001)PASSSGADQR 305.63 3.5173999999999975e-102 8603400.0 26386.0 28208.0 25722.0 34639.0 35077.0 21009.8 23302.3 26055.0 22986.0 29108.0 True False 24919.571751526957 30371.462896984347 24067.074523996074 29921.10844439208 30670.313667641305 23903.70924202466 24385.903122631476 26130.815736362554 27583.842282501508 28267.576408333425 0.8815602509234057 1.0744275511370223 0.8514021215098221 1.0584957129742183 1.084999761726992 0.8456228753653505 0.862681072136145 0.9244094845237265 0.9758120711887295 1.0 14.786860574937675 -6.773737179937977 24.99396702464408 0.9132917141728986 0.9909434369982351 0.1388047830748591 0.08396858118605949 420.96540957482824 855562.076321569 0.02926445894185967 0.025992839931981215 1.68369266563692e-07 6.773737179937977 0.0776517228253365 VSMPDVELNLKS(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 VSMPDVELNLKSPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VSMPDVELNLKS(1)PK;VSMPDVELNLKS(1)PK 116.04 0.0014898 333150000.0 9451.0 9852.099999999999 12674.8 13526.7 8854.2 10967.599999999999 12184.0 15530.0 13433.5 8959.900000000001 True False 9671.189911555268 8698.611551882974 10953.631777692794 11164.51577260655 8053.339173335979 10857.275901784033 11264.951070605324 15118.09395145057 22795.668355979324 10109.990441816712 0.9565973348059275 0.8603976039288797 1.083446304003081 1.1043052747535878 0.7965723825045314 1.0739155456444762 1.1142395371623193 1.495361844153626 2.2547665586005303 1.0 13.30349401283883 -7.777852477037748 3.1510353205487607 1.6930226102819363 0.9853270410454572 0.4492707936239628 0.29835397438212546 0.19396275247796063 3.9305535935166334 0.16781788306189688 0.07729374033032628 1.6678136462417377e-08 7.777852477037748 -0.7076955692364791 VSMPDVELNLKS(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 VSMPDVELNLKSPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VSMPDVELNLKS(1)PK;VSMPDVELNLKS(1)PK 89.46 0.010719 67472000.0 88008.0 96049.0 77136.0 79986.0 73953.0 43448.0 83852.0 80752.0 71629.0 104972.0 True False 83116.86768393786 103415.64945378812 72173.15373932672 69091.76881645391 64662.36299179173 49432.56761832512 87751.28414958592 80986.97495078681 85956.80148148026 101941.18560998961 0.8153413871595477 1.0144638679153641 0.7079881728612561 0.6777610874645679 0.6343104860402489 0.4849126221412225 0.8608030564340114 0.7944480385055536 0.8431999389367217 1.0 16.637377511914828 -9.806986316713687 12.611734520063003 0.9999999945117986 0.7551286265810525 0.21745905800736964 0.1368106983749107 0.0 0.0 0.14440996255737668 0.035024560530326806 1.5596016403142706e-10 9.806986316713687 -0.24487136793074604 VSNGS(ph)PSLER ddPTM_A459_Selumetinib_30min_R1 1 VSNGSPSLER 10 0 P46527;E7ES52 P46527 CDKN1B Cyclin-dependent kinase inhibitor 1B 1 VS(0.04)NGS(0.96)PSLER 145.81 0.0008868999999999998 18893000.0 1037.5 916.47 1141.2 1159.5 1487.2 810.61 1129.0 1080.8 515.77 829.94 True False 1061.671731376424 809.1692663446564 986.2313081628914 957.0150915106641 1352.6830225864865 802.455999374992 1043.8386210368856 1052.1336730668238 875.2240196496405 936.4708833001893 1.1336943308210696 0.8640623865347388 1.05313611533478 1.0219379038652816 1.4444474961352096 0.8568936991901772 1.1146514426143446 1.12350922151368 0.9345982189700223 1.0 9.871090328747638 -5.715846834570825 3.3119797421943957 1.085583776479018 0.995082081462484 0.021838143149266465 0.15960797435600488 0.7956171508975659 17.78315277358116 0.0444657633387703 0.07931853667537891 1.9237700776551053e-06 5.715846834570825 -0.09050169501653393 VSNGS(ph)PSLER ddPTM_A459_Selumetinib_30min_R2 2 VSNGSPSLER 10 0 P46527;E7ES52 P46527 CDKN1B Cyclin-dependent kinase inhibitor 1B 1 VS(0.025)NGS(0.965)PS(0.009)LER;VS(0.121)NGS(0.878)PS(0.001)LER 110.92 0.0091632 54156000.0 46822.0 47822.0 58025.0 69457.0 63670.0 39753.0 41276.0 41296.0 44712.0 56112.0 True False 44219.82068331668 51489.79362803407 54291.734672843195 59996.83677999198 55671.205382978056 45228.614908195486 43195.415786842386 41416.16452307916 53655.649357661554 54491.90076351535 0.8114934524898008 0.9449072780832172 0.9963266818028457 1.1010230133165482 1.021641833060305 0.8300061894423395 0.7926942386227709 0.7600425740848639 0.984653656889618 1.0 15.733754194821945 -6.765975821283656 24.99664507676536 0.8534329101499244 0.9815796569259782 0.1939434454722675 0.09900702703385633 159.99734865884236 881609.5078600333 0.035505150517522 0.03236478728457506 1.7140527322556961e-07 6.765975821283656 0.12814674677605375 VSNLQVS(ph)PK ddPTM_A459_Selumetinib_30min_R2 4 VSNLQVSPK 9 0 O00443;A0A0C4DGF9;O00443-2 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 VSNLQVS(1)PK;VSNLQVS(1)PK;VSNLQVS(1)PK;VSNLQVS(1)PK 104.17 0.014582 78666000.0 643878.0 590741.0 516335.0 486066.0 436324.0 343742.0 460246.0 456737.0 338611.0 493402.0 True False 608093.8384078556 636048.9351683023 483114.56824304233 419862.9722893817 381509.0783339492 391089.340320804 481648.3509601474 458066.02905311936 406342.66158183746 479156.2022476467 1.269093117349588 1.32743546297574 1.008261118142325 0.8762549046007758 0.7962102473981342 0.8162042742768749 1.0052011195948427 0.9559847642676926 0.8480379877704758 1.0 18.870136517605538 -5.387016436472516 3.2546603308503017 0.895935893196614 1.3018793843270393 0.8342902661536729 0.06984943552783753 0.0950173558385788 1.8609079959268522 0.020264544941192862 0.04847164028723503 4.1018857854141755e-06 5.387016436472516 0.40594349113042527 VSNQDSKS(ph)PLGFYCDQNPVESSMCQSNSR ddPTM_A459_Selumetinib_30min_R2 4 VSNQDSKSPLGFYCDQNPVESSMCQSNSR 29 1 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 VS(0.001)NQDS(0.24)KS(0.63)PLGFY(0.129)CDQNPVESSMCQSNSR;VS(0.003)NQDS(0.111)KS(0.648)PLGFY(0.238)CDQNPVESSMCQSNSR;VS(0.001)NQDS(0.077)KS(0.741)PLGFY(0.178)CDQNPVES(0.002)S(0.001)MCQSNSR;VS(0.032)NQDS(0.112)KS(0.774)PLGFY(0.079)CDQNPVES(0.002)S(0.001)MCQSNSR 105.44 9.5641e-11 69782500.0 142433.0 140644.0 137497.0 166648.0 161808.0 109735.0 103047.0 99559.0 81286.3 150873.0 True False 134517.1440644749 151430.9425582625 128650.59271541455 143950.25491616558 141480.23245812644 124850.00017485044 107838.88968375673 99848.70020712017 97545.83132898745 146516.90447486885 0.918099822997201 1.0335390520363916 0.878059724074236 0.9824822291468523 0.9656239528483465 0.8521201060200204 0.7360167079031735 0.6814824580480173 0.6657650301758791 1.0 17.160707600484457 -7.00614877122869 2.871665562924339 0.7449431250008277 0.9570390307635755 0.44779550652954014 0.09496760036059466 0.21168947286922862 3.5388115688599053 0.03646333383758902 0.0292831285557055 9.859416851568962e-08 7.00614877122869 0.21209590576274784 VSNQDSKSPLGFY(ph)CDQNPVESSMCQSNSR ddPTM_A459_Selumetinib_30min_R1 1 VSNQDSKSPLGFYCDQNPVESSMCQSNSR 29 1 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 VS(0.038)NQDS(0.226)KS(0.226)PLGFY(0.509)CDQNPVESSMCQSNSR 79.78399999999998 0.00030174 7700800.0 511.79 344.57 505.15 693.67 542.93 384.18 274.92 336.46 0.0 247.58 True False 523.7137112300148 304.2275842137531 436.55340459032954 572.5335562985787 493.82207736207687 380.31549800753044 254.18256306063805 327.53598782389304 0.0 279.35930463342044 1.874695786192767 1.0890189772378094 1.562695057403517 2.0494522530755366 1.7676951122500744 1.3613847532538295 0.9098768462148784 1.1724541921153862 0.0 1.0 8.125978062778096 -7.408491059777361 1.434179206867949 0.6315050635230353 1.6483581945460333 0.5801532319807916 0.3649275053950898 0.3163464219392656 1.253447103684035 0.24038919307295212 0.12484417311118058 3.903992190362305e-08 7.408491059777361 1.016853131022998 VSNS(ph)PEPQK ddPTM_A459_Selumetinib_30min_R1 4 VSNSPEPQK 9 0 O60271;O60271-3;D6RHI8 O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 VS(0.006)NS(0.994)PEPQK;VS(0.001)NS(0.999)PEPQK;VSNS(1)PEPQK;VS(0.002)NS(0.998)PEPQK 165.63 0.00096401 210209000.0 26926.499999999996 33054.4 25269.600000000002 24004.199999999997 25200.299999999996 27359.7 26811.5 27998.6 17261.3 22417.8 True False 27553.8350601516 29184.375481426323 21838.12711597703 19812.31708464017 22920.93731447432 27084.486258620018 24789.086968937507 27255.986175729795 29291.16538452866 25295.342997863678 1.0892848957406374 1.1537449989862203 0.8633259931609297 0.7832397088394264 0.9061326947181586 1.0707301443157913 0.9799861963141229 1.0775100451506707 1.1579667208704167 1.0 14.626584181373502 -7.4752690985213555 1.5583691583451342 1.0864228416077288 0.9635854858945049 0.14019408802506783 0.1104093063581047 0.8311151684001714 3.9018035933133772 0.08118231928410234 0.04055099725764988 3.347579514094651e-08 7.4752690985213555 -0.12283735571322396 VSNS(ph)PEPQK ddPTM_A459_Selumetinib_30min_R2 5 VSNSPEPQK 9 0 O60271;O60271-3;D6RHI8 O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 VS(0.024)NS(0.976)PEPQK;VS(0.316)NS(0.684)PEPQK;VS(0.045)NS(0.955)PEPQK;VS(0.446)NS(0.554)PEPQK;VS(0.015)NS(0.985)PEPQK 117.98 0.007361199999999998 207929000.0 334622.0 276288.0 261930.0 321234.0 329879.0 245203.0 383721.0 427023.0 312851.0 381063.0 True False 316025.048837999 297478.4011940585 245077.7089678206 277481.37504044076 288436.65086432226 278977.4875187851 401564.7868287367 428265.56623253704 375429.94178729964 370060.7210694221 0.853981605842231 0.8038637560192522 0.6622635016750261 0.7498266074782528 0.7794306027150949 0.7538694912353314 1.085132152551269 1.157284580203247 1.01450902625483 1.0 18.497402487876492 -7.261683950392305 24.99774137169935 1.077338482991547 0.7638677818344414 0.8509208775156597 0.06079789086539039 7.83450347437607 800707.4441651088 0.02492852043000903 0.017999107952551777 5.4741418831368874e-08 7.261683950392305 -0.31347070115710574 VSNS(ph)PEPQKAVEQEDELSDVSQGGSK ddPTM_A459_Selumetinib_30min_R1 1 VSNSPEPQKAVEQEDELSDVSQGGSK 26 1 O60271;O60271-3;D6RHI8 O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 VS(0.266)NS(0.734)PEPQKAVEQEDELSDVSQGGSK 136.77 2.1181e-09 27599000.0 1893.5 1351.9 4369.0 4143.6 2192.5 2259.4 1578.4 1871.8 1303.3 1054.8 True False 1937.614865890371 1193.6189195187408 3775.713797199152 3419.998045005249 1994.1887621173148 2236.6724873710614 1459.34001722287 1822.1537835367158 2211.6049107341983 1190.1938546220679 1.6279825831445232 1.0028777370034065 3.1723519513534084 2.8734798383673636 1.675515929084129 1.879250576437643 1.2261364075739296 1.5309722667954115 1.8581888170112149 1.0 10.216980858468066 -6.799548048612781 2.224110533260077 1.4671836880222235 2.144729248149559 0.20564098670733433 0.6152470697596726 0.5662833972783584 5.75011871526843 0.2642859655887008 0.23772144485599203 1.5865433803968942e-07 6.799548048612781 0.6775455601273355 VSNS(ph)PEPQKAVEQEDELSDVSQGGSK ddPTM_A459_Selumetinib_30min_R2 2 VSNSPEPQKAVEQEDELSDVSQGGSK 26 1 O60271;O60271-3;D6RHI8 O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 VS(0.102)NS(0.898)PEPQKAVEQEDELSDVSQGGSK;VS(0.059)NS(0.941)PEPQKAVEQEDELSDVSQGGSK 80.93 7.6457e-05 9675900.0 32916.1 50927.0 43871.4 53121.0 34857.4 21738.0 11654.5 13195.900000000001 7650.700000000001 43539.0 True False 31086.75493558842 54832.937143885516 41048.7618875687 45885.828161163736 30478.30178289019 24732.21218208321 12196.45734295363 13234.297884301159 9181.053778418798 42281.91594209251 0.7352257872647847 1.2968413545635524 0.9708349532643532 1.0852353101502539 0.7208353998109253 0.5849359384743913 0.2884556451901889 0.31300137634316955 0.2171390196932602 1.0 15.36775313132985 -6.612754818364651 1.8525757879533873 0.40399698238725956 1.0417180081653505 0.5153748987777296 0.24421557405972666 0.23785694928376375 1.6697103050047806 0.09012100501828463 0.09185441783282958 2.439187476875466e-07 6.612754818364651 0.637721025778091 VSNS(ph)PPLGR ddPTM_A459_Selumetinib_30min_R2 3 VSNSPPLGR 9 0 H0Y9Y2 H0Y9Y2 BOD1L1 1 VS(0.016)NS(0.984)PPLGR;VS(0.001)NS(0.999)PPLGR;VS(0.002)NS(0.998)PPLGR 119.03 0.007026999999999999 29567900.0 54022.0 57348.0 83305.0 74248.0 87217.0 63685.0 66588.0 64732.0 55797.0 78571.0 True False 51019.67350720038 61746.40719711639 77945.24699562625 64135.29431505586 76260.02073012723 72457.03067512962 69684.4739416189 64920.35940304054 66957.9590984397 76302.45107802564 0.6686505189070335 0.8092322897199662 1.0215300543349612 0.8405404205098491 0.9994439189397072 0.949602924302343 0.9132665197132487 0.8508292785595319 0.8775335281165422 1.0 16.2194417813185 -4.9484918521676855 3.58644115293285 0.9255563225190871 0.6737165433179639 0.6486002070496614 0.060752477729644594 0.146673956250417 3.6886775390292854 0.015310476702499064 0.07850565892875684 1.1259215921987348e-05 4.9484918521676855 -0.2518397792011232 VSPAS(ph)PAGS(ph)PSADFAVHGESLGDR ddPTM_A459_Selumetinib_30min_R1 3 VSPASPAGSPSADFAVHGESLGDR 24 0 Q96C92-4;A0A0A0MRP9;Q96C92-3;Q96C92-2;Q96C92 Q96C92-4 SDCCAG3 Serologically defined colon cancer antigen 3 2 VS(0.14)PAS(0.866)PAGS(0.991)PS(0.004)ADFAVHGESLGDR;VS(0.159)PAS(0.842)PAGS(0.989)PS(0.009)ADFAVHGESLGDR;VS(0.07)PAS(0.933)PAGS(0.963)PS(0.034)ADFAVHGESLGDR 91.1 0.00018869 7774600.0 2151.38 2565.59 2727.6099999999997 2253.85 2612.17 2216.71 2606.27 2343.4300000000003 1029.26 2097.33 True False 2201.5029681432416 2265.209530089568 2357.215543689258 1860.2574075043633 2375.8996847160715 2194.411910011643 2409.6769555799856 2281.2746238665704 1746.579045823893 2366.5427352242145 0.9302612352506973 0.9571809105213366 0.9960587267679014 0.7860654193206936 1.0039538476751702 0.9272648565983901 1.0182266813583167 0.963969333792924 0.738029793346798 1.0 11.208565259279824 VSPAS(ph)PAGS(ph)PSADFAVHGESLGDR ddPTM_A459_Selumetinib_30min_R2 3 VSPASPAGSPSADFAVHGESLGDR 24 0 Q96C92-4;A0A0A0MRP9;Q96C92-3;Q96C92-2;Q96C92 Q96C92-4 SDCCAG3 Serologically defined colon cancer antigen 3 2 VS(0.143)PAS(0.885)PAGS(0.961)PS(0.01)ADFAVHGESLGDR;VS(0.019)PAS(0.981)PAGS(0.994)PS(0.006)ADFAVHGESLGDR;VS(0.038)PAS(0.963)PAGS(0.984)PS(0.016)ADFAVHGESLGDR 121.91 5.9625e-07 11076000.0 25350.199999999997 21931.0 25953.1 29430.7 29645.300000000003 22410.5 22001.2 18934.5 16620.8 25988.1 True False 23941.33736889102 23613.037180720487 24283.305801598726 25422.187889210694 25920.99238165541 25497.342952736017 23024.29939455075 18989.59626022478 19945.42442395376 25237.756027807132 0.9486317778217799 0.9356234823216248 0.9621816525543402 1.0073077757467959 1.0270719929733643 1.0102856579104287 0.9122958225439068 0.7524280779678634 0.7903010236717462 1.0 14.623296020794127 -7.533579820252818 5.949208182557936 0.8281337924242047 0.9807559360714035 0.44662819653574715 0.06624709353598786 0.12576036274711472 16.856528152100957 0.03043395917115203 0.01809222179570526 2.926982863190229e-08 7.533579820252818 0.15262214364719884 VSPAS(ph)PAGSPSADFAVHGESLGDR ddPTM_A459_Selumetinib_30min_R1 2 VSPASPAGSPSADFAVHGESLGDR 24 0 Q96C92-4;A0A0A0MRP9;Q96C92-3;Q96C92-2;Q96C92 Q96C92-4 SDCCAG3 Serologically defined colon cancer antigen 3 1 VS(0.064)PAS(0.927)PAGS(0.008)PSADFAVHGESLGDR;VS(0.021)PAS(0.975)PAGS(0.004)PSADFAVHGESLGDR 166.35 6.9794e-16 25339000.0 3832.2000000000003 4518.3 4532.1 4847.2 4622.0 4101.5 4712.3 4018.9 2028.3899999999999 3263.5 True False 3921.48280383685 3989.295335499315 3916.665713043323 4000.727513213013 4203.94091608038 4060.242633864042 4356.847417105506 3912.3057167730026 3442.029682255919 3682.4020141819497 1.0649252278089503 1.083340526139035 1.0636170895950956 1.0864450697683479 1.141630082725851 1.1026071075963253 1.1831536590318168 1.0624330808275768 0.9347240385486728 1.0 11.846431421454902 -8.096187805608704 4.9738415443721875 0.9708257671883687 1.1034113072327503 0.6747209799689349 0.037276036174411296 0.1351400875865081 5.2469056107523 0.0275706970414545 0.010007139607578125 8.013314619599394e-09 8.096187805608704 0.1325855400443816 VSPGLPS(ph)PNLENGAPAVGPVQPR ddPTM_A459_Selumetinib_30min_R1 1 VSPGLPSPNLENGAPAVGPVQPR 23 0 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 VSPGLPS(1)PNLENGAPAVGPVQPR 127.3 9.2583e-06 20985000.0 1337.7 1608.1 1566.4 1862.3 1455.9 1582.4 1877.5 1228.3 798.17 1297.4 True False 1368.8658072889089 1419.8229044145921 1353.6914836193068 1537.0842647005684 1324.2141020600222 1566.4824927042437 1735.8786634160776 1195.7214939193013 1354.4361939697035 1463.9339277461816 0.9350598284147728 0.969868159692493 0.9246943854244843 1.049968332291476 0.9045586532028349 1.0700499954365714 1.1857629845962872 0.8167865169708785 0.9252030903163391 1.0 10.51563472608186 -5.727144857928422 24.994549865070717 0.9930895512835828 0.9458735285526818 0.05429938516191157 0.09539350834349758 711.2577671514895 518374.0863461022 0.027220866076287546 0.04714455318994942 1.874369212238184e-06 5.727144857928422 -0.047216022730900975 VSPGLPS(ph)PNLENGAPAVGPVQPR ddPTM_A459_Selumetinib_30min_R2 3 VSPGLPSPNLENGAPAVGPVQPR 23 0 Q9UGP4;C9JRJ5 Q9UGP4 LIMD1 LIM domain-containing protein 1 1 VSPGLPS(1)PNLENGAPAVGPVQPR;VSPGLPS(1)PNLENGAPAVGPVQPR;VS(0.018)PGLPS(0.982)PNLENGAPAVGPVQPR 175.6 1.7209999999999998e-16 78961000.0 63162.6 61194.1 67129.0 69911.0 73829.0 65948.0 59090.5 62816.7 57713.0 69792.0 True False 59652.27555192131 65887.49069995576 62809.99322452895 60389.00119679823 64553.94098036574 75031.73838366102 61838.325335604415 62999.486197135455 69257.21263595273 67776.92361860687 0.8801266325924669 0.9721227695537894 0.9267164968710037 0.8909964922075567 0.9524471978637236 1.1070395995822755 0.9123802325933228 0.9295123300615571 1.0218406050070332 1.0 16.048506534209885 -6.5263656690196745 24.99986675838268 0.9896498632689898 0.9220106229219921 0.30287998444032715 0.05455305265552515 151.80305492968603 1088352.6482813528 0.01829205614312347 0.01837658222182274 2.976009621645742e-07 6.5263656690196745 -0.06763924034699775 VSPLNLSSVT(ph)P ddPTM_A459_Selumetinib_30min_R2 1 VSPLNLSSVTP 11 0 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 VSPLNLSS(0.002)VT(0.998)P 95.094 0.04058 0.0 7269.9 6531.2 7611.0 6646.2 6345.9 7612.0 6210.2 5539.6 5380.3 8631.1 True False 6865.868061715518 7032.122038882026 7121.316546230234 5740.9760946655115 5548.671308934199 8660.483905143867 6498.986605277847 5555.719318869851 6456.510338142477 8381.897716709038 0.8191304992935711 0.8389653842785174 0.8496067104271773 0.6849255727877787 0.6619827032574145 1.0332366485312123 0.775359808116285 0.662823564142844 0.7702921887571637 1.0 13.033061201203754 -10.666759984827229 6.227283959816117 1.0000009881158827 0.7881138126563854 0.26769544212636576 0.10495203152781388 1.4931941124860097e-06 2.0527190391576827e-07 0.10538568912841144 0.025559664965953754 2.153971809907068e-11 10.666759984827229 -0.2118871754594973 VSPPAPGS(ph)APETPEDK ddPTM_A459_Selumetinib_30min_R1 2 VSPPAPGSAPETPEDK 16 0 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 VSPPAPGS(0.927)APET(0.073)PEDK;VSPPAPGS(1)APETPEDK 156.29 8.479100000000001e-05 30559000.0 3392.5 4100.799999999999 4217.0 5087.1 3957.7 4198.1 3753.5 4464.3 2305.7 3319.1 True False 3471.538649344115 3620.6764295897997 3644.3545623229134 4198.733481693747 3599.726733788687 4155.870925569822 3470.370473039812 4345.892261909903 3912.6044983348734 3745.1388157718143 0.9269452535976789 0.9667669498236303 0.9730893143334313 1.1211155816205585 0.9611731128975095 1.1096707305129256 0.9266333355722686 1.1604088595082644 1.044715480734069 1.0 11.870803478676956 -5.570421905555569 11.707760485824851 1.0470890068142007 0.9526091450220959 0.2720310002730787 0.06871035134523375 0.8708713421638343 212.1953015131958 0.017536309583433392 0.030393770700848397 2.688921319015383e-06 5.570421905555569 -0.09447986179210477 VSPPAPGS(ph)APETPEDK ddPTM_A459_Selumetinib_30min_R2 4 VSPPAPGSAPETPEDK 16 0 M0R300;M0R0P8;Q13459-2;Q13459 M0R300 MYO9B Unconventional myosin-IXb 1 VSPPAPGS(1)APETPEDK;VSPPAPGS(1)APETPEDK;VSPPAPGS(1)APETPEDK;VSPPAPGS(0.971)APET(0.029)PEDK 188.16 8.983799999999998e-07 39857900.0 139561.0 133315.0 135676.0 147411.0 141725.0 105264.0 130643.0 131111.0 94142.0 126236.0 True False 131804.758326948 143539.83182471155 126946.75387285934 127333.36750184103 123920.23846242431 119763.16050854765 136718.15836419346 131492.5113034056 112973.03054725715 122591.23867948276 1.07515642836071 1.1708816500337296 1.0355287640478466 1.0386824447932748 1.0108409034549055 0.9769308296302546 1.1152359649586852 1.072609370129585 0.9215424508649218 1.0 16.903496350975097 -5.366291118522515 6.522711560988938 1.0253627854051512 1.12243634496817 0.36126661348349 0.0539340381159114 0.2485827183429418 13.11994308170466 0.01415872667469311 0.029844315592131895 4.30238114372149e-06 5.366291118522515 0.09707355956301877 VSPS(ph)KSPS(ph)LSPSPPSPLEK ddPTM_A459_Selumetinib_30min_R2 1 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.058)PS(0.491)KS(0.491)PS(0.945)LS(0.012)PS(0.001)PPS(0.001)PLEK 74.14699999999998 0.019838 6785200.0 20415.0 23993.0 25655.0 25342.0 23901.0 19313.0 20731.0 18163.0 14192.0 20178.0 True False 19280.416027720108 25833.185950345483 24004.385231051994 21890.375882611614 20898.342702348968 21973.190444041447 21695.03257769718 18215.85132295348 17030.796557611655 19595.408711259868 0.9839251791998215 1.3183285090400425 1.2250004878570688 1.1171175965333664 1.0664917997010397 1.1213438192496217 1.1071487661918902 0.929597927318879 0.8691217829932508 1.0 14.258228043816873 -7.716101056377023 3.640638835503246 0.9202902915994812 1.1444709166776161 0.5193038363776177 0.08883447787838422 0.17839407149396921 4.846778613250506 0.04982321256424082 0.025220734785254655 1.922644295009884e-08 7.716101056377023 0.22418062507813497 VSPS(ph)KSPSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R1 1 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.02)PS(0.451)KS(0.154)PS(0.367)LS(0.008)PS(0.001)PPS(0.999)PLEK 102.65 0.0021136 149590000.0 6709.4 7543.9 8321.2 8297.8 6857.0 6611.9 6851.2 6567.2 4013.0 5791.5 True False 6865.715965780219 6660.656680936041 7191.226745079785 6848.7449989971365 6236.785560701677 6545.390289124868 6334.408468067231 6393.0165227280195 6809.767902076521 6534.895438987207 1.050623690903964 1.019244568352011 1.1004348596271187 1.0480267148786349 0.9543818441979951 1.0016059706288565 0.9693205541248802 0.9782890303932428 1.0420622587852628 1.0 12.673948437153882 -6.14910383413048 6.807913242893398 0.9894511175694118 1.056245998339941 0.5442580029694933 0.028564228780707974 0.19033558540063455 10.2316803912997 0.008392565697151301 0.01088373271297766 7.094081374786693e-07 6.14910383413048 0.0667948807705292 VSPS(ph)KSPSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R2 2 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.062)PS(0.651)KS(0.282)PS(0.003)LS(0.001)PS(0.029)PPS(0.97)PLEK;VS(0.108)PS(0.569)KS(0.264)PS(0.057)LS(0.002)PS(0.024)PPS(0.976)PLEK 101.71 0.0022824 46159400.0 363611.0 311806.0 330468.0 322001.0 338586.0 253619.0 271797.0 282103.0 204876.0 321029.0 True False 343402.9562701607 335720.51758568827 309206.0486663532 278143.9083172919 296049.79968275473 288552.7151259433 284436.0990555379 282923.8730253343 245856.92471372904 311760.058636487 1.1014975996991627 1.076855447917205 0.991807770433121 0.8921730048864546 0.9496078521974797 0.9255602413854961 0.9123558043308913 0.9075051957031618 0.7886094382616178 1.0 18.25007658240154 -5.423678898032487 2.032811474926237 0.9083243403406276 1.1003699173256103 0.6649434608978811 0.050558874487995266 0.19965704175750973 1.567363554828994 0.014336984233894966 0.042508219388127697 3.7698242342880004e-06 5.423678898032487 0.1920455769849827 VSPS(ph)KSPSLSPSPPSPLEK ddPTM_A459_Selumetinib_30min_R2 2 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VS(0.03)PS(0.542)KS(0.386)PS(0.035)LS(0.007)PSPPSPLEK;VS(0.025)PS(0.595)KS(0.218)PS(0.113)LS(0.006)PS(0.042)PPS(0.001)PLEK 78.428 0.0041325 60132000.0 239516.0 219869.0 237486.0 267311.0 272787.0 201641.0 196102.0 202744.0 154818.0 207617.0 True False 226204.65957851594 236732.24530973658 222206.40931520652 230902.780662805 238517.05831327848 229415.21743524892 205221.1315687412 203333.95147392395 185785.92597634695 201622.5577562513 1.1219213866534856 1.174135711520586 1.1020910149539902 1.1452229514018544 1.1829879601152082 1.1378449910976587 1.017848071428795 1.0084881063741966 0.9214540676591861 1.0 17.62129753263219 -7.383094819356176 2.368300685052958 0.9738199830356509 1.146906576509205 0.8665866885091074 0.03051877220506392 0.10328300982364497 1.1303633448550512 0.015541225598423422 0.009312781584890784 4.139092962879142e-08 7.383094819356176 0.17308659347355415 VSPSKS(ph)PSLS(ph)PSPPSPLEK ddPTM_A459_Selumetinib_30min_R2 2 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.066)PS(0.398)KS(0.526)PS(0.269)LS(0.73)PS(0.009)PPS(0.002)PLEK;VS(0.08)PS(0.422)KS(0.499)PS(0.431)LS(0.464)PS(0.094)PPS(0.011)PLEK 70.994 0.029762 14495800.0 132239.0 118586.0 131084.0 137969.0 133303.0 106125.0 103219.0 111720.0 80316.0 106203.0 True False 124889.68577465958 127681.16488591109 122650.19815346813 119177.38419019965 116556.2853960598 120742.75544316787 108018.88802456825 112045.08670375837 96381.44421653992 103136.64344146736 1.2109147787569567 1.237980611210926 1.1892009867770732 1.1555290167828258 1.1301151705815249 1.170706660738794 1.0473376330680346 1.0863751520801312 0.9345024328936865 1.0 16.654197473669598 -7.300756210894228 0.6125297445921223 0.970582175864919 1.2166752143219013 0.8330233227190247 0.03789235313028859 0.2994642350330021 0.22824683589620332 0.03329926970459641 0.023729508187761872 5.00315305740695e-08 7.300756210894228 0.24609303845698227 VSPSKS(ph)PSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R1 1 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.038)PS(0.182)KS(0.765)PS(0.014)LS(0.009)PS(0.074)PPS(0.917)PLEK 89.71 0.0056301 172060000.0 1959.6 2244.2 3119.4 2755.3 2334.8 1957.3 2171.9 1926.3 1197.0 1688.9 True False 2005.254867282159 1981.4480206997243 2695.802613637683 2274.1385783866585 2123.6177522424205 1937.6113390862092 2008.071834393278 1875.208266495766 2031.2215745790193 1905.6867662791162 1.052247883946558 1.0397553552667698 1.4146095052658 1.193343323061927 1.114358240724323 1.0167522666221933 1.053726073941349 0.9840065532685311 1.0658737891878274 1.0 10.896095290650388 -6.571870624372686 3.2037231762550493 1.0248311744399001 1.1810692227550854 0.3448190122998106 0.0981624188037109 0.30630282974720063 6.450749788570774 0.03622613896544948 0.03733806469235552 2.679966563642941e-07 6.571870624372686 0.15623804831518529 VSPSKS(ph)PSLSPSPPS(ph)PLEK ddPTM_A459_Selumetinib_30min_R2 2 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 2 VS(0.056)PS(0.337)KS(0.593)PS(0.014)LS(0.001)PS(0.037)PPS(0.962)PLEK;VS(0.057)PS(0.332)KS(0.576)PS(0.03)LS(0.005)PSPPS(1)PLEK 105.79 0.0016753 59477000.0 256725.0 252358.0 242894.0 237765.0 238121.0 174774.0 203790.0 195981.0 147233.0 236341.0 True False 242457.25225160163 271713.0471411364 227266.46448299094 205380.9968324976 208206.11115125052 198847.5320595919 213266.63880222428 196551.27226359904 176683.71403373955 229517.22124233612 1.056379346783755 1.1838460123837409 0.990193516864825 0.8948391572571618 0.907148099930226 0.8663730372094319 0.929196674863218 0.8563682986387765 0.7698059129392638 1.0 17.808242881098998 -5.533909572837962 3.0319873607869523 0.8844247173828339 1.1195350726544082 0.6822353523780951 0.06263175763307881 0.13175728763702418 2.4641844704703444 0.01695515679297269 0.03589815970094899 2.9247612972341733e-06 5.533909572837962 0.2351103552715743 VSPSKS(ph)PSLSPSPPSPLEK ddPTM_A459_Selumetinib_30min_R1 2 VSPSKSPSLSPSPPSPLEK 19 1 P46821 P46821 MAP1B Microtubule-associated protein 1B;MAP1B heavy chain;MAP1 light chain LC1 1 VS(0.001)PS(0.035)KS(0.481)PS(0.481)LS(0.001)PSPPSPLEK;VS(0.015)PS(0.224)KS(0.626)PS(0.132)LS(0.004)PSPPSPLEK 146.17 2.6055e-05 112750000.0 4980.2 6072.7 6299.700000000001 6925.5 5990.700000000001 5455.2 5364.2 4761.0 2664.59 4560.0 True False 5096.228970217704 5361.705460878363 5444.2353417751165 5716.091432735752 5448.842242743986 5400.325640925295 4959.574075257805 4634.722814092478 4521.614616046371 5145.320418161391 0.9904590105272337 1.0420547264565292 1.0580945207141323 1.1109301206120645 1.0589898781640998 1.0495606108151816 0.963899946396349 0.9007646633110231 0.8787819316531715 1.0 12.329045206542974 -7.385327298094352 2.8815300973370497 0.9182798816805172 1.0553929173134644 0.6696918431097831 0.040244761778005754 0.1546221329920932 2.468973468859838 0.019665390402143886 0.01220357069342237 4.1178706633629825e-08 7.385327298094352 0.1371130356329472 VSPSTSYT(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 VSPSTSYTPSR 11 0 Q9BTE3;Q9BTE3-2 Q9BTE3 MCMBP Mini-chromosome maintenance complex-binding protein 1 VSPS(0.007)T(0.023)S(0.023)YT(0.911)PS(0.035)R 108.68 0.022986000000000003 16397000.0 54009.0 47260.0 55619.0 63357.0 70454.0 52855.0 43513.0 48329.0 50309.0 51817.0 True False 51007.39599515723 50884.69003514891 52040.53409338843 54727.667303078844 61602.93865324862 60135.29648008131 45536.440719373764 48469.62938870335 60372.20575090788 50320.90857326552 1.0136421905199149 1.0112037218299137 1.034173181066856 1.0875731153263506 1.22420163705027 1.1950359837506983 0.9049208770361183 0.9632105373879176 1.1997439526158 1.0 15.618870350699696 -5.642312405235371 4.077335788911023 1.083683117129583 1.0146711419002943 0.07840204831328146 0.09957499412855171 0.6568072425783352 19.722953559305573 0.030042966862069812 0.054285949512152765 2.2787023213994783e-06 5.642312405235371 -0.06901197522928881 VSPTEIVLES(ph)FHK ddPTM_A459_Selumetinib_30min_R1 1 VSPTEIVLESFHK 13 0 Q14207;H0YET3 Q14207 NPAT Protein NPAT 1 VSPTEIVLES(1)FHK 84.41 0.028904000000000006 0.0 1632.8 2222.1 1316.4 1167.5 1570.6 1471.1 2341.3 2145.9 1071.9 1924.5 True False 1670.8410631242662 1961.9354989737371 1137.6401104676047 963.6180416892628 1428.539507311951 1456.3020696519302 2164.693856008556 2088.9837611344365 1818.9360115215113 2171.5283212174554 0.7694309334116897 0.9034814235689033 0.5238891426614197 0.44375108179524714 0.6578498163501032 0.6706346196007531 0.9968526934960407 0.9619878040380607 0.8376294215226882 1.0 11.084495053301708 -7.2524817197944715 22.250325142489494 0.9459497993351623 0.6561854933051667 0.5623767163971595 0.12422766057757861 121.29143075821572 301282.0212900124 0.05347890351979131 0.04066769974191327 5.5913706212080274e-08 7.2524817197944715 -0.2897643060299956 VSQGS(ph)AESLSPSFR ddPTM_A459_Selumetinib_30min_R1 1 VSQGSAESLSPSFR 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 VS(0.004)QGS(0.988)AES(0.008)LSPSFR 102.39 0.007622399999999999 6551100.0 2164.1 2564.3 2561.2 2933.5 2605.4 2015.9 2199.8 2164.5 1059.4 1790.2 True False 2214.5193193944287 2264.0705638892714 2213.4031076645615 2421.219293614947 2369.74203002073 1995.6218762907506 2033.8673149308602 2107.09042871312 1797.724424485391 2019.9896080246745 1.0963023327431782 1.1208327779979428 1.0957497498361013 1.1986295790811672 1.1731456541195153 0.9879367044082208 1.006870187277724 1.0431194399923773 0.8899671648525785 1.0 10.980132155614488 -6.769665492327041 24.999269786626954 0.9896043491896868 1.1371773567137746 0.7228687223738643 0.046823770408250934 103.47049098771386 314446.3261342729 0.016731633955839795 0.015001704073583621 1.6995521985917264e-07 6.769665492327041 0.14757300752408786 VSQGSAESLS(ph)PSFR ddPTM_A459_Selumetinib_30min_R1 2 VSQGSAESLSPSFR 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 VSQGSAES(0.007)LS(0.496)PS(0.496)FR;VSQGSAES(0.005)LS(0.547)PS(0.448)FR 203.92 2.9759e-05 162746000.0 3505.7 4213.4 4764.1 4836.9 4282.9 3698.3 4223.8 4027.0 2440.84 3216.6 True False 3587.375989095258 3720.09316924348 4117.161387328099 3992.2262148580676 3895.5124512074112 3661.0984597877305 3905.1953653991127 3920.190878460492 4141.927208099793 3629.4819423372646 0.9883989081882876 1.0249653334403601 1.1343661306871762 1.0999438152011325 1.0732971022026443 1.0087110276212328 1.0759649524208124 1.080096537396194 1.1411896446666243 1.0 11.82554792308731 -5.0331806735477675 8.145765860527709 1.0780000516769406 0.9971496070457561 0.3111106760105212 0.043179862715384223 0.2719078959586211 63.14286227786532 0.011060149739807285 0.031044554833346442 9.264443273335572e-06 5.0331806735477675 -0.08085044463118451 VSQGSAESLS(ph)PSFR ddPTM_A459_Selumetinib_30min_R2 2 VSQGSAESLSPSFR 14 0 Q86YV5 Q86YV5 SGK223 Tyrosine-protein kinase SgK223 1 VSQGSAES(0.175)LS(0.732)PS(0.093)FR;VSQGSAES(0.159)LS(0.819)PS(0.021)FR 184.22 7.4938e-05 132293000.0 170725.0 137584.0 163744.0 177091.0 173599.0 127224.0 144642.0 148079.0 137063.0 166415.0 True False 161236.78796632457 148136.2503977129 153208.889310987 152970.9003009855 151789.9416252491 144747.9511755153 151368.1396026856 148509.88537420184 164479.42986019753 161610.16655190327 0.9976896342999635 0.9166270511214216 0.9480151687225811 0.9465425570974636 0.9392351042253256 0.8956611719661063 0.9366251073942907 0.9189390032990647 1.0177542253034728 1.0 17.302158432258338 -8.26537136917181 24.992583253084643 1.0088771228843212 0.9360236846552914 0.555605656970305 0.02553950295317098 251.54085092367004 1598813.6548367555 0.021044376230406777 0.0062553602453671395 5.427859917389438e-09 8.26537136917181 -0.07285343822902979 VSQSALNPHQS(ph)PDFKR ddPTM_A459_Selumetinib_30min_R1 1 VSQSALNPHQSPDFKR 16 1 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 VSQS(0.002)ALNPHQS(0.998)PDFKR 68.676 0.024237 35397000.0 3090.2 3441.7 4040.7 3930.7 3421.0 3279.7 3254.1 3431.3 1447.4 2797.5 True False 3162.1956475175193 3038.7441639970775 3491.995133976336 3244.27703337729 3111.571154026605 3246.709195729341 3008.640617109058 3340.290777566797 2456.1320860866076 3156.586374957563 1.0017770058834623 0.9626678326006303 1.1062567974314603 1.0277802182495026 0.9857392716105977 1.0285507222253627 0.9531310915417311 1.0581971727644246 0.7780975377616992 1.0 11.624149513354626 -8.240630775416829 24.99936469800618 0.889048719180026 1.0145475441388199 0.3742968633795458 0.06539413016634203 686.0527767651204 824223.5845192758 0.041371022639699315 0.01560041395498359 5.746047669281265e-09 8.240630775416829 0.12549882495879383 VSQSALNPHQS(ph)PDFKR ddPTM_A459_Selumetinib_30min_R2 1 VSQSALNPHQSPDFKR 16 1 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 VSQSALNPHQS(1)PDFKR 84.37100000000002 0.0088017 31061000.0 50463.0 34414.0 54707.0 56442.0 51037.0 39673.0 37320.0 45599.0 35785.0 42400.0 True False 47658.468479394534 37053.44314154919 51187.21118047795 48754.50223211919 44625.27578343096 45137.59563436318 39055.45394817708 45731.68554067918 42942.99991644118 41175.80183156994 1.1574387470180183 0.8998839486627778 1.2431381759087483 1.1840571418997499 1.0837742994288522 1.096216555029068 0.9485050007753058 1.110644687084544 1.0429183648226203 1.0 15.329509123907057 -7.027573761846477 23.32657922996615 1.0329692895525695 1.1105973852081403 0.1707018777373751 0.09199499014374593 671.7369819707235 568266.5559308283 0.03553834617559074 0.02762070510766208 9.384826284977203e-08 7.027573761846477 0.07762809565557083 VSRLS(ph)TSTTIENIEITIK ddPTM_A459_Selumetinib_30min_R1 1 VSRLSTSTTIENIEITIK 18 1 Q9UEY8-2;Q9UEY8 Q9UEY8-2 ADD3 Gamma-adducin 1 VS(0.213)RLS(0.456)T(0.129)S(0.037)T(0.129)T(0.037)IENIEITIK 120.25 0.00052657 8316600.0 2186.7 3272.3 2627.0 2697.1 2573.1 2449.1 2841.8 2681.2 1704.7 2174.9 True False 2237.645855422483 2889.1775947490037 2270.2678290780896 2226.102115837354 2340.3635593177014 2424.4642776048795 2627.440738053694 2610.0858662349815 2892.7513936381374 2454.0696003200005 0.9118102661516622 1.1773005926043283 0.9251032769331627 0.9071063492034128 0.9536663340813674 0.9879362334665404 1.0706463817126812 1.0635745073793494 1.1787568670672317 1.0 11.260960450782951 -7.304234281067571 3.0266051595002184 1.0879487641283143 0.9785354978610221 0.261934458166025 0.0831323750057998 0.3832826323984464 7.044550300687441 0.03851287253718067 0.02543592272923037 4.963245059261019e-08 7.304234281067571 -0.1094132662672922 VSRPENEQLR ddPTM_A459_Selumetinib_30min_R1 1 VSRPENEQLR 10 1 Q8ND56-3;Q8ND56-2;Q8ND56;A0A140TA76;K7EMZ9 Q8ND56-3;A0A140TA76 LSM14A Protein LSM14 homolog A 0 126.39 0.0097645 4806300.0 1823.5 2664.0 2667.8 2817.1 2954.3 2352.9 2133.5 2220.0 1463.4 1926.0 False True 1865.9840020866611 2352.0976415399987 2305.5274131764468 2325.1463685163344 2687.084086624028 2329.2319622622704 1972.568377309295 2161.1183884237144 2483.282917492844 2173.2208608286905 0.8586260309387633 1.082309526811324 1.0608803986435622 1.0699079925220816 1.2364523712511168 1.071787964235761 0.9076704594843237 0.9944310895302371 1.142673974032221 1.0 11.085619085334327 -4.758283423875198 24.995204867622018 1.0637334959168117 0.858625749072133 0.3499821040503216 0.08351052462586116 109.89229967962437 870201.5721664407 0.0222723778249503 0.1543678513730964 1.7446831878217253e-05 4.758283423875198 -0.2051077468446787 VSS(ph)GYVPPPVATPFSSK ddPTM_A459_Selumetinib_30min_R1 2 VSSGYVPPPVATPFSSK 17 0 Q15942;Q15942-2;H7C3R3 Q15942 ZYX Zyxin 1 VS(0.336)S(0.662)GY(0.002)VPPPVATPFSSK;VS(0.135)S(0.86)GY(0.004)VPPPVATPFSSK 121.45 0.0014273 21044000.0 4634.2 4478.200000000001 5224.0 4891.0 3786.3 4415.7 3051.2 3637.5 2762.6 2410.41 True False 4742.167843416505 3953.8902621413035 4514.609493377975 4036.878665440842 3443.8298335255604 4371.282067134815 2821.0455274647866 3541.0216837348003 4687.9304276791945 2719.8096028816644 1.7435661078599518 1.4537378858991155 1.6598990931551616 1.4842504641368022 1.266202542220893 1.6072014976722635 1.0372216953995095 1.301937341490027 1.7236244855935088 1.0 11.409289945478621 -1.5228787452893604 0.038971971198148755 1.0240784112127326e-13 3.729699961654338 0.35508009407681573 0.20547492219063515 939.3419599178175 2.800295715655734 74.6703626141695 234.7550921596989 0.029999999999376723 1.5228787452893604 3.7296999616542355 VSS(ph)GYVPPPVATPFSSK ddPTM_A459_Selumetinib_30min_R2 2 VSSGYVPPPVATPFSSK 17 0 Q15942;Q15942-2;H7C3R3 Q15942 ZYX Zyxin 1 VS(0.193)S(0.807)GYVPPPVATPFSSK;VS(0.044)S(0.952)GY(0.005)VPPPVATPFSSK 162.79 1.1063e-05 0.0 38635.0 53655.0 36916.0 47429.0 46807.0 49267.0 44278.0 42369.0 34377.0 59416.0 True False 36487.82136815899 57770.16597198298 34540.86475110175 40969.08838041141 40926.686200110795 56053.08204870245 46337.01473519253 42492.28677543446 41253.36057363417 57700.50569869245 0.6323657119869202 1.0012072731849924 0.5986232587192816 0.7100299708697322 0.7092951041681812 0.9714487138363619 0.8030608081177109 0.7364283252095897 0.7149566554764011 1.0 15.816296342541502 VSS(ph)PAGPTEDNDLSR ddPTM_A459_Selumetinib_30min_R1 1 VSSPAGPTEDNDLSR 15 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 VS(0.004)S(0.996)PAGPTEDNDLSR 149.35 0.00028702 4917100.0 1432.8 1370.1 1733.4 1667.9 1431.6 1204.6 1374.0 1334.6 864.04 1274.5 True False 1466.1814522565207 1209.6880550577907 1498.0138008846434 1376.6325753606177 1302.1120327695085 1192.4828176892904 1270.3580737862533 1299.2020726082383 1466.2127730152497 1438.094489681291 1.0195306795045536 0.841174250883807 1.0416657678847179 0.9572615605151965 0.9054426132027537 0.8292103378781231 0.8833620342066596 0.903419129918345 1.019552458851428 1.0 10.48994275551307 -4.303984361195802 8.024729308891319 0.9271172385203243 6.29610496118724 0.12552356195004466 0.06914222758643707 14621.036071509647 8244.314703944312 0.01745428476674618 1403604.1256103092 4.966102039016088e-05 4.303984361195802 5.368987722666915 VSS(ph)PAGPTEDNDLSR ddPTM_A459_Selumetinib_30min_R2 1 VSSPAGPTEDNDLSR 15 0 Q86YC2;H3BN63 Q86YC2 PALB2 Partner and localizer of BRCA2 1 VS(0.045)S(0.955)PAGPTEDNDLSR 155.06 0.00017606 4812900.0 14880.0 14946.0 15812.0 12899.0 13723.0 14778.0 14628.0 12457.0 14776.0 14857.0 True False 14053.029169359552 16092.310141035448 14794.673134803912 11142.133947983868 11998.994054823424 16813.53535867263 15308.230984832113 12493.247807632633 17731.612875935032 14428.039806878178 0.9740082060669218 1.1153497187721837 1.0254111669244876 0.772255559114285 0.831644091327169 1.1653374667470235 1.0610055967224548 0.8659005640999697 1.2289689461129685 1.0 13.816587688180315 -6.7636933035265665 24.99971490762569 1.0556589723047705 0.9482790480462405 0.18269070470355542 0.12661456370418805 131.14145563776648 1454557.5425087055 0.0462792318307932 0.042780735513165066 1.7230849789541114e-07 6.7636933035265665 -0.10737992425852994 VSS(ph)PIEK ddPTM_A459_Selumetinib_30min_R2 2 VSSPIEK 7 0 Q06190 Q06190 PPP2R3A Serine/threonine-protein phosphatase 2A regulatory subunit B subunit alpha 1 VS(0.048)S(0.952)PIEK;VS(0.244)S(0.756)PIEK 95.502 0.023749 13265200.0 275310.0 215070.0 241910.0 240960.0 246880.0 196837.0 234740.0 220450.0 203467.0 251410.0 True False 260009.372353251 231565.1774409532 226345.77397169304 208140.83232081466 215864.72726479676 223949.51004161895 245655.8751284858 221091.47300253803 244166.08534298043 244151.14005837243 1.064952521995544 0.9484501173559536 0.9270723614789493 0.8525081319343899 0.8841438430850134 0.9172576871362402 1.0061631294031788 0.9055516715984975 1.0000612132493194 1.0 17.897414989060643 -8.344105285791882 1.2531259231064673 1.004090947744349 0.9327758683657921 0.12053482345482247 0.0584062238611428 0.9688377143800277 3.1536335305356924 0.05815070700148066 0.018353834869133927 4.52787797479874e-09 8.344105285791882 -0.07131507937855686 VSS(ph)PPNAMMSSR ddPTM_A459_Selumetinib_30min_R1 1 VSSPPNAMMSSR 12 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 VS(0.014)S(0.985)PPNAMMS(0.001)SR 87.641 0.028241 56848000.0 3640.1 4427.1 3942.2 4978.9 4145.6 3781.5 3734.0 3338.8 2119.0 3037.5 True False 3724.9072475983835 3908.7730738970486 3406.8708929545646 4109.428580528197 3770.631211965126 3743.4615433272857 3452.3413737393535 3250.244178049141 3595.788234363358 3427.39271275553 1.0868049155078177 1.1404508912416116 0.9940124107387548 1.1989955411979414 1.1001456582235778 1.0922184462245779 1.0072791953168874 0.94831390810656 1.0491322517495938 1.0 11.742895790871374 -7.256564029206687 3.8894657067585623 0.995174039333311 1.1043636433091204 0.46780550644867047 0.05283631292947933 0.1930264644635313 6.764768528043186 0.021672794059764394 0.01527224922000928 5.539058740815307e-08 7.256564029206687 0.10918960397580946 VSS(ph)PPNAMMSSR ddPTM_A459_Selumetinib_30min_R2 4 VSSPPNAMMSSR 12 0 Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9;Q9Y6Q9-4 Q9Y6Q9-2 NCOA3 Nuclear receptor coactivator 3 1 VS(0.047)S(0.95)PPNAMMS(0.002)SR;VS(0.172)S(0.826)PPNAMMS(0.001)SR;VS(0.191)S(0.809)PPNAMMSSR;VS(0.037)S(0.963)PPNAMMSSR 105.36 0.023218 127295200.0 255221.0 237508.0 281355.0 301618.0 343621.0 209863.0 223403.0 230225.0 203476.0 243709.0 True False 241036.83855061218 255724.0998914128 263252.92561616184 260537.10807992917 300452.2579692835 238769.72330336383 233791.68216464628 230894.91663419927 244176.88559446073 236672.487937974 1.018440464502921 1.0804977888195935 1.1123089460451099 1.1008339429304919 1.269485357537732 1.0088613399202508 0.987827880636119 0.9755883273374433 1.0317079425744384 1.0 17.852532483752533 -6.9618354919837975 24.99999985453421 0.9969747061246129 1.1158344117512151 0.4791451719915988 0.06028010097325851 145.89426697077445 95568.93158815427 0.021861102252507793 0.019279645090511173 1.0918538454908111e-07 6.9618354919837975 0.1188597056266022 VSS(ph)PSPATDGK ddPTM_A459_Selumetinib_30min_R2 1 VSSPSPATDGK 11 0 A0A0A0MQS0;F8W9L8;A8MW92-4;A8MW92 A0A0A0MQS0 PHF20L1 PHD finger protein 20-like protein 1 1 VS(0.025)S(0.974)PS(0.002)PATDGK 152.96 0.00056908 9213100.0 107240.0 98198.0 111560.0 112140.0 94324.0 74744.0 95056.0 104300.0 96440.0 121290.0 True False 101280.03011573375 105729.47084366386 104382.35105734383 96866.33854770983 82474.175852741 85039.30754152295 99476.29234989062 104603.49573220554 115730.69475874213 117788.04255073392 0.8598498448780163 0.8976248229791562 0.8861880102335857 0.8223783709283339 0.7001914121903974 0.7219689341971587 0.8445364248840791 0.888065490070017 0.9825334749823553 1.0 16.845833563449347 -8.079638461062611 2.070931576879277 0.9985867954598102 0.8159502066773411 0.5662693141310933 0.06026958234277573 0.2907966997782195 2.234887446683713 0.062111783747635006 0.019758049120819503 8.324564812474453e-09 8.079638461062611 -0.18263658878246913 VSS(ph)PSPELGTTPASIFR ddPTM_A459_Selumetinib_30min_R1 4 VSSPSPELGTTPASIFR 17 0 A0A5E8;Q99501 A0A5E8 GAS2L1 GAS2-like protein 1 1 VS(0.099)S(0.896)PS(0.005)PELGTTPASIFR;VS(0.004)S(0.996)PSPELGTTPASIFR;VS(0.005)S(0.984)PS(0.011)PELGTTPASIFR;VS(0.078)S(0.887)PS(0.036)PELGTTPASIFR 180.56 7.7055e-08 60508000.0 6589.8 7157.2 7662.3 8655.2 7589.1 6572.2 6934.2 6804.93 3721.8999999999996 5266.24 True False 6743.329518481315 6319.231696707987 6621.801746001155 7143.731798226047 6902.66724496443 6506.08963508015 6411.147711243553 6624.4411508721505 6315.792463179318 5942.213201521541 1.1348178346671647 1.0634474870558175 1.1143662338311255 1.20220051956346 1.1616323768384746 1.0948933359399198 1.078915800194099 1.1148104125876737 1.0628687071615202 1.0 12.53678465342677 -8.571321608050768 0.7114164744134959 0.9997678062637841 1.1289160295478833 0.5329491504368253 0.03679572381394837 0.7208417730293405 0.8209991637354058 0.040734274078666616 0.0158073642327378 2.6833566039143075e-09 8.571321608050768 0.12914822328409914 VSS(ph)PSPELGTTPASIFR ddPTM_A459_Selumetinib_30min_R2 2 VSSPSPELGTTPASIFR 17 0 A0A5E8;Q99501 A0A5E8 GAS2L1 GAS2-like protein 1 1 VS(0.231)S(0.769)PSPELGTTPASIFR;VS(0.122)S(0.869)PS(0.009)PELGTTPASIFR 223.68 2.5676e-12 23334000.0 25986.0 23021.0 25247.0 32060.0 28908.0 19203.1 17749.9 21375.5 18728.0 22946.0 True False 24541.802150200067 24786.63667581808 23622.63550685519 27693.372693415226 25276.31859920102 21848.152716614306 18575.305520759597 21437.69916609548 22474.12330404108 22283.48935913215 1.1013446662087696 1.112331927749013 1.0600958910043519 1.2427754130914876 1.1343070284835062 0.9804637130432432 0.8335905217262181 0.9620440865698598 1.0085549413665238 1.0 14.443687540726195 -6.8161294644585135 4.7042376685743195 0.9433836949065453 1.1319957783338555 0.6585923484591643 0.06241359778428582 0.1259818113325926 5.752168484708705 0.02310740207573423 0.020733569679231432 1.5271107541840212e-07 6.8161294644585135 0.18861208342731017 VSS(ph)PTVNTTLR ddPTM_A459_Selumetinib_30min_R2 1 VSSPTVNTTLR 11 0 Q9NSK0-5;Q9NSK0;Q9NSK0-3 Q9NSK0-5 KLC4 Kinesin light chain 4 1 VS(0.036)S(0.959)PT(0.003)VNT(0.001)T(0.001)LR 113.95 0.006805599999999999 14392000.0 53482.0 42144.0 52402.0 51030.0 61123.0 50436.0 53887.0 49989.0 44387.0 50683.0 True False 50509.684545409094 45376.30928568166 49030.512370983706 44079.62596833994 53444.18229344697 57383.10118757702 56392.85227506476 50134.45971387557 53265.640276402824 49219.65009975138 1.0262097443407918 0.9219145035309966 0.996157271976043 0.8955696734740216 1.0858301955648588 1.165857560370322 1.1457385853165505 1.018586268132142 1.0822027415565045 1.0 15.586946781328704 -6.286060067239626 20.8282586752484 1.0912415945113085 0.9598304523505234 0.5172929112033438 0.0579182100752216 72.71540035020205 61514.0794201732 0.018044176499260114 0.02048319511858158 5.175352467361802e-07 6.286060067239626 -0.1314111421607851 VSS(ph)PVFGATSSIK ddPTM_A459_Selumetinib_30min_R1 2 VSSPVFGATSSIK 13 0 F6Q6H0;I6L8A6;Q99708-3;Q99708;Q99708-2 F6Q6H0 RBBP8 DNA endonuclease RBBP8 1 VS(0.084)S(0.916)PVFGATSSIK;VS(0.226)S(0.774)PVFGATSSIK 198.48 0.00015051 96585000.0 6479.6 6589.8 7436.5 7698.5 7104.700000000001 6310.6 6518.6 6376.2 3260.4 5499.4 True False 6630.5620728931835 5818.263152485097 6426.664145770542 6354.101493742858 6462.081139436667 6247.121093566359 6026.896753845029 6207.082463183459 5532.660669805705 6205.3015586922675 1.0685318046477885 0.9376277844764829 1.0356731393284495 1.0239794849038648 1.0413806772024976 1.0067393235410955 0.9712496156456196 1.000286997251358 0.8916022239170085 1.0 12.599285607291446 -7.516180518657131 1.5744402841987575 0.9549074445538536 1.0177745934119973 0.2809033654023362 0.04215863958425073 0.5293697911566219 2.5366519875369313 0.027107778284363317 0.013095671011967394 3.046628366170807e-08 7.516180518657131 0.0628671488581437 VSS(ph)PVFGATSSIK ddPTM_A459_Selumetinib_30min_R2 1 VSSPVFGATSSIK 13 0 F6Q6H0;I6L8A6;Q99708-3;Q99708;Q99708-2 F6Q6H0 RBBP8 DNA endonuclease RBBP8 1 VS(0.126)S(0.871)PVFGAT(0.002)S(0.001)SIK 83.869 0.030161 38719000.0 77549.0 65107.0 81456.0 86781.0 85259.0 55429.0 69178.0 76855.0 61695.0 77941.0 True False 73239.13703324345 70100.49754799926 76215.20964258704 74961.27809442492 74548.00219486932 63063.841615635734 72394.91407360644 77078.63532596987 74035.72390232884 75690.64081496198 0.9676115335354125 0.9261448548093452 1.006930431847016 0.9903638981955497 0.984903832127858 0.8331788572091166 0.9564579358046066 1.0183377296857754 0.9781357788120878 1.0 16.207827300835767 -7.688192334577743 7.770069424002189 0.9985182994852636 0.9512710595603246 0.17561899617364185 0.0462895367048983 0.4491708105384831 41.01863980472841 0.02346153611054684 0.013433020913789217 2.0502539884539854e-08 7.688192334577743 -0.047247239924938955 VSS(ph)QAEDTSSSFDNLFIDR ddPTM_A459_Selumetinib_30min_R1 2 VSSQAEDTSSSFDNLFIDR 19 0 H8Y6P7;P0CAP2-3;P0CAP2;Q9BZD3 H8Y6P7 GCOM1;POLR2M;GCOM2 DNA-directed RNA polymerase II subunit GRINL1A;Putative GRINL1B complex locus protein 2 1 VS(0.003)S(0.997)QAEDTSSSFDNLFIDR;VS(0.002)S(0.998)QAEDTSSSFDNLFIDR 187.75 4.365100000000001e-15 4868500.0 1086.15 1176.92 1175.96 1190.7199999999998 1111.4099999999999 834.6500000000001 1865.35 2131.54 1430.31 914.25 True False 1111.455181720004 1039.1256592647362 1016.2710910859039 982.7831045826457 1010.8831617353727 826.2541788015654 1724.6451476980994 2075.0046349822883 2427.1316042908215 1031.6028930491339 1.077406034055264 1.007292308180105 0.9851378839022897 0.9526757933741439 0.9799150124012164 0.8009420915439524 1.6718110809097517 2.0114373941402457 2.3527770430314416 1.0 10.010672008832238 -7.379555107362019 4.31925452422067 1.8785312353920751 0.9711402497505649 0.5816566986411446 0.3264011855837559 0.14644174558160442 4.494866841017645 0.1362472676119624 0.08911050315046194 4.172966445889401e-08 7.379555107362019 -0.9073909856415102 VSS(ph)QAEDTSSSFDNLFIDR ddPTM_A459_Selumetinib_30min_R2 4 VSSQAEDTSSSFDNLFIDR 19 0 H8Y6P7;P0CAP2-3;P0CAP2;Q9BZD3 H8Y6P7 GCOM1;POLR2M;GCOM2 DNA-directed RNA polymerase II subunit GRINL1A;Putative GRINL1B complex locus protein 2 1 VS(0.259)S(0.741)QAEDTSSSFDNLFIDR;VS(0.045)S(0.955)QAEDTSSSFDNLFIDR;VS(0.043)S(0.957)QAEDTSSSFDNLFIDR;VS(0.174)S(0.826)QAEDTSSSFDNLFIDR 102.79 0.0026226999999999995 1194800.0 11388.0 10241.2 14990.0 12652.5 14637.900000000001 12060.6 13306.099999999999 17293.3 17399.3 21128.8 True False 10755.10054977598 11026.667109351814 14025.559719877967 10929.207673220088 12798.956137513662 13721.838174773799 13924.860015536942 17343.620639940058 20879.646177061193 20518.756644784782 0.5241594671629183 0.5373945069012963 0.6835482267607487 0.5326447339097394 0.6237686015330149 0.6687460849759361 0.6786405363931347 0.8452569003175081 1.0175882748903373 1.0 14.324655691549484 -7.844397159991449 1.2027460600016424 1.0300320380031471 0.5850438331619624 0.9150747764563811 0.05077694525430356 0.12640615004352 0.3299238926761601 0.044814125300918384 0.016716015997257454 1.4308787697520727e-08 7.844397159991449 -0.44498820484118473 VSS(ph)SAGNAAVIK ddPTM_A459_Selumetinib_30min_R2 1 VSSSAGNAAVIK 12 0 Q9ULD2-2 Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VS(0.027)S(0.947)S(0.027)AGNAAVIK 182.72 0.00010424 5058700.0 61482.0 43928.0 50708.0 60044.0 59204.0 33889.0 53484.0 61421.0 46270.0 41232.0 True False 58065.07657194647 47297.13634921751 47445.50248669594 51865.90361832259 51766.264229524604 38556.9021362875 55971.11197653543 61599.7249412061 55525.292891818724 40041.52502639836 1.4501215059532733 1.1812021724456225 1.184907479308451 1.2953029032767538 1.292814501830198 0.9629229184170162 1.397826679669046 1.5383960750894219 1.3866927609578383 1.0 15.289209301428752 VSS(ph)SGLTDSLFILK ddPTM_A459_Selumetinib_30min_R1 1 VSSSGLTDSLFILK 14 0 Q6P3S1 Q6P3S1 DENND1B DENN domain-containing protein 1B 1 VS(0.032)S(0.936)S(0.032)GLTDSLFILK 160.48 0.00029039 6211500.0 1873.5 2682.9 2386.0 2292.1 2219.0 1796.8 2217.5 2489.6 1303.2 1804.4 True False 1917.1489048035962 2368.784820753629 2061.9943053598467 1891.8277630457894 2018.2918417962694 1778.7258233638672 2050.2321896805065 2423.5677206394935 2211.435218037909 2036.0123163443889 0.9416195026981914 1.1634432668888395 1.012761214068738 0.9291828678337863 0.9912964796893095 0.8736321529515728 1.0069841784462528 1.1903502258723813 1.0861600395465623 1.0 10.99153057332286 -10.087404745242088 5.285892983383209 1.0000000176535144 1.0221747086270025 0.004630658700754742 0.09529337771039359 68928788.78006575 16.025691373732496 0.5186043121681814 0.024695444841074728 8.177023667239126e-11 10.087404745242088 0.02217469097348812 VSS(ph)SPGVK ddPTM_A459_Selumetinib_30min_R1 1 VSSSPGVK 8 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 VS(0.013)S(0.493)S(0.493)PGVK 112.3 0.011233 16124000.0 9188.2 9263.1 9111.1 9413.9 8445.1 9024.6 9254.8 9027.8 6144.0 8743.7 True False 9402.267182875044 8178.571945701644 7873.862663689905 7769.93908578891 7681.242196103508 8933.820717681196 8556.70298491777 8788.353417572787 10425.919259994556 9866.039065850378 0.9529931029180088 0.8289620475972352 0.7980773855785698 0.78754392050638 0.7785537990307403 0.9055124004732661 0.8672885772908955 0.8907681551750776 1.0567482239232264 1.0 13.268255284542336 -8.096487783396688 2.741691486470253 1.0293179802786288 0.8405576819671242 0.6409344045176883 0.053465294801260756 0.18274703391393032 2.494438477212878 0.046591644538760725 0.015125653482352142 8.007781538941105e-09 8.096487783396688 -0.18876029831150454 VSS(ph)SPGVK ddPTM_A459_Selumetinib_30min_R2 1 VSSSPGVK 8 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 VS(0.017)S(0.491)S(0.491)PGVK 125.57 0.005056399999999999 22651000.0 170800.0 129000.0 140580.0 159520.0 144210.0 124000.0 187160.0 203970.0 159790.0 180870.0 True False 161307.61976657313 138893.88519962385 131535.23585193127 137793.10081265107 126093.05054624252 141079.87444007344 195863.31085050417 204563.51893094854 191752.46490563493 175647.813143303 0.9183582583801919 0.790752146093084 0.7488578052754787 0.7844851487005534 0.7178742979473873 0.8031974433121626 1.1150910867914323 1.1646232040706055 1.091687174887813 1.0 17.422326089215417 -7.251320755518031 7.087144406865399 1.1071007685722434 0.7873065849786299 0.8463078751209544 0.06226010289691525 0.051227437976684165 16.317708397702795 0.02477210113082185 0.0182414328229968 5.6063375756532044e-08 7.251320755518031 -0.31979418359361345 VSSGYSS(ph)PTTSEMSIK ddPTM_A459_Selumetinib_30min_R1 2 VSSGYSSPTTSEMSIK 16 0 Q96AY4;A0A087WW06 Q96AY4 TTC28 Tetratricopeptide repeat protein 28 1 VSSGYS(0.005)S(0.433)PT(0.433)T(0.127)S(0.001)EMSIK;VSSGYS(0.099)S(0.701)PT(0.099)T(0.099)S(0.002)EMSIK 181.75 1.1044e-10 0.0 1793.9699999999998 2365.2799999999997 2411.49 2458.8900000000003 2442.81 2059.26 2333.9300000000003 2346.1 1045.0900000000001 1575.6399999999999 True False 1835.7660105420387 2088.351918011159 2084.022903366395 2029.4910205818521 2221.8582668131357 2038.5457140584817 2157.8797810421784 2283.8738067931854 1773.4413996464384 1777.8887420332903 1.0325539316046046 1.1746246368728372 1.1721897181164402 1.1415174485332618 1.2497172709874398 1.146610395725376 1.2137316188718927 1.2845988350099022 0.9974985260428807 1.0 10.795949329673965 -8.285533118824947 24.222302004861703 0.9987491037608496 1.1781674186600244 0.5515057225308038 0.0642694422209709 448.249521823567 450634.94719537033 0.061453372257232866 0.01590526588287994 5.181635759096603e-09 8.285533118824947 0.1794183148991748 VSSPLSPLS(ph)PGIK ddPTM_A459_Selumetinib_30min_R1 1 VSSPLSPLSPGIK 13 0 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 VSSPLS(0.005)PLS(0.995)PGIK 104.7 0.0075540999999999985 12916000.0 1213.7 1316.6 1182.0 1059.1 1138.1 971.86 1351.2 1440.8 676.5 822.69 True False 1241.9768485509073 1162.451859929266 1021.4908922612483 874.1480667692491 1035.159055947875 962.0839707782777 1249.2778961426395 1402.5853036220205 1147.9710903949078 928.2902751792093 1.3379186249808983 1.2522503908649167 1.1004002945781657 0.941675346755617 1.1151243136184255 1.0364042331398382 1.3457836730019201 1.5109339622794682 1.2366509927870228 1.0 9.858432194566099 -7.272728442356516 24.746426274444403 1.315920000327081 1.1254895428943148 0.14293572991661874 0.15769163161671104 974.8390071670672 2136906.8224829226 0.06704214236858783 0.04567867825170091 5.33668485858281e-08 7.272728442356516 -0.1904304574327662 VSSPLSPLS(ph)PGIK ddPTM_A459_Selumetinib_30min_R2 1 VSSPLSPLSPGIK 13 0 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 VSS(0.002)PLS(0.399)PLS(0.599)PGIK 155.09 0.00036711 6981800.0 30657.0 34994.0 33102.0 37040.0 36044.0 28694.0 33596.0 35590.0 32133.0 43759.0 True False 28953.20666969458 37677.92727655522 30972.253358732527 31995.088102436053 31515.83048255162 32646.33804180218 35158.28056921108 35693.561007758304 38560.497871035484 42495.56397046389 0.6813230362072195 0.8866320094667501 0.728834976287395 0.7529041884153818 0.7416263613881293 0.7682293159938456 0.8273400158578313 0.8399361644562889 0.9074005441564811 1.0 15.375024628521325 -8.273318933621914 0.8800423091966347 0.9985998523658053 0.7617326681251264 0.7106230973267884 0.049701546574161884 0.2991952638216155 0.49419776541347205 0.045465703533571995 0.016670459927174298 5.329433731576421e-09 8.273318933621914 -0.23686718424067887 VSSPLSPLSPGIKS(ph)PTIPR ddPTM_A459_Selumetinib_30min_R1 2 VSSPLSPLSPGIKSPTIPR 19 1 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 VSSPLSPLSPGIKS(0.995)PT(0.005)IPR;VSSPLS(0.001)PLS(0.005)PGIKS(0.985)PT(0.009)IPR 195.36 1.861e-15 368590000.0 3824.7000000000003 4852.1 5816.7 6022.0 4827.0 4075.9 4456.8 4404.700000000001 2353.4 3663.7 True False 3913.808068429311 4284.0138763199075 5026.82408884603 4970.370746940245 4390.398702276066 4034.9001466211016 4120.619987809733 4287.873047517986 3993.5479144647134 4133.971582460061 0.9467428574098388 1.0362949504772743 1.2159793526821117 1.2023233947782623 1.0620292410581615 0.976034804820791 0.9967702742062919 1.0372284767778548 0.9660317771435227 1.0 12.013312756157703 -6.564240149679694 5.7091373198039115 0.9988819665387588 1.1073935261397756 0.30977027451080097 0.07402864980312215 0.2505692021130459 20.321890385534317 0.027001688102580225 0.027301825151930553 2.7274691705537625e-07 6.564240149679694 0.10851155960101677 VSSPLSPLSPGIKS(ph)PTIPR ddPTM_A459_Selumetinib_30min_R2 3 VSSPLSPLSPGIKSPTIPR 19 1 Q9P2B4 Q9P2B4 CTTNBP2NL CTTNBP2 N-terminal-like protein 1 VSSPLSPLS(0.007)PGIKS(0.497)PT(0.497)IPR;VSSPLSPLS(0.002)PGIKS(0.946)PT(0.051)IPR;VSSPLSPLSPGIKS(0.96)PT(0.04)IPR 115.99 0.00025867 208552000.0 151985.0 171490.0 186592.0 203237.0 185206.0 121970.0 122384.0 131291.0 96959.0 124389.0 True False 143538.2821441605 184642.7315727402 174586.873866009 175555.76999661958 161938.76651735243 138770.26036657856 128075.09849929529 131673.03507360484 116353.5092608138 120797.56636856464 1.1882547509791035 1.528530227251251 1.445284695002283 1.4533055199223348 1.3405797102175232 1.1487835768410892 1.060245684987777 1.09003052819672 0.963210706628049 1.0 16.88223186433681 -6.84314694614169 1.8632220256645124 1.031131794692897 1.4177967679014485 0.7963465748506633 0.08770580073933497 0.14543665536298653 1.0384237053206167 0.0365738548597542 0.031548249587089086 1.4350038090592282e-07 6.84314694614169 0.3866649732085514 VSSS(ph)AGNAAVIK ddPTM_A459_Selumetinib_30min_R2 1 VSSSAGNAAVIK 12 0 Q9ULD2-2 Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VS(0.011)S(0.268)S(0.721)AGNAAVIK 165.51 0.00050849 4787300.0 44363.0 31777.0 45558.0 48647.0 47665.0 35415.0 47879.0 57651.0 32363.0 35418.0 True False 41897.4820591598 34214.193720840594 42626.84787979992 42021.19467924425 41676.896569493474 40293.09478463872 50105.46837043867 57818.754865363146 38836.50429777243 34395.390312984535 1.218113290121414 0.994731951273263 1.2393186264761746 1.2217100691943859 1.2117000618469538 1.17146787456073 1.4567495212148662 1.6810030163703682 1.1291194530538977 1.0 15.069927606737856 -7.24573173236542 23.64806367287131 1.3734682411750803 1.1744811692029655 0.09147032354652018 0.18513255040301893 622.9491216429469 937858.6512590931 0.06878461239376285 0.053049754229436766 5.678952911509004e-08 7.24573173236542 -0.19898707197211474 VSSS(ph)PGVK ddPTM_A459_Selumetinib_30min_R1 2 VSSSPGVK 8 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 VS(0.027)S(0.032)S(0.941)PGVK;VS(0.008)S(0.143)S(0.849)PGVK 154.85 0.0006596 18760400.0 12184.9 13606.9 12444.2 12808.9 12902.8 13218.3 13073.900000000001 12900.2 8464.9 12669.4 True False 12468.784462311894 12013.7978223238 10754.345991097665 10572.066067831773 11735.744018174366 13085.335903256127 12087.725197142723 12558.044790244869 14364.31704816536 14295.640900406555 0.8722088466811792 0.8403818972524791 0.7522814867846759 0.7395307521701326 0.8209316462223538 0.9153374790551707 0.8455532201287288 0.8784527309921256 1.004803992226529 1.0 13.80328767969416 -7.9201958738750005 0.8013085073084143 1.0108094383186992 0.8057909994830018 0.6647917785580975 0.04908411574735571 0.402235044238448 0.49940543584273195 0.049920739409974185 0.02119759275450575 1.2017223160642825e-08 7.9201958738750005 -0.20501843883569737 VSSS(ph)PGVK ddPTM_A459_Selumetinib_30min_R2 1 VSSSPGVK 8 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 VS(0.026)S(0.015)S(0.959)PGVK 112.36 0.011207 21084000.0 205370.0 166890.0 177530.0 197160.0 168030.0 138390.0 195710.0 250570.0 173830.0 224330.0 True False 193956.3575612478 179689.92636407117 166107.91308004883 170306.4678800297 146920.56919274066 157451.96632065927 204810.90279200778 251299.11721590374 208600.85721601106 217853.01002066204 0.8903083668334544 0.8248218665742956 0.7624770163345207 0.7817494367595709 0.674402291613075 0.7227440479510744 0.9401334540779708 1.1535260274442365 0.9575302962131509 1.0 17.732995521184876 -7.4555657416371295 4.428664688985558 1.043647688961219 0.7747233392899722 0.7342663886812794 0.07135573714655086 0.11166456633722412 4.251198085642825 0.033173033728632687 0.02115230919238769 3.5029525809324974e-08 7.4555657416371295 -0.2689243496712468 VSSS(ph)PQKEGR ddPTM_A459_Selumetinib_30min_R1 2 VSSSPQKEGR 10 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 VS(0.004)S(0.149)S(0.847)PQKEGR;VSS(0.002)S(0.998)PQKEGR 191.33 0.00084493 7121100.0 5316.5 5691.0 10842.0 10198.0 8379.5 7789.700000000001 5333.4 7125.0 5981.6 5229.7 True False 5440.364105891818 5024.695074325879 9369.715950843027 8417.110740168819 7621.575704520884 7711.342690481708 4931.097344055026 6936.021854738267 10150.338321221267 5900.9829365917985 0.9219420161607826 0.8515013732996773 1.587822918914361 1.4263913030445479 1.291577316256881 1.3067895252948334 0.8356399937165477 1.175401103387069 1.7201097563389578 1.0 12.526739571277947 -5.233426532540018 24.52522358462049 1.2881069777144802 0.8867214905854931 0.305853711149324 0.244715204362289 735.6195179301661 644031.0030794644 0.06406711541059494 0.169419679680072 5.842160276840923e-06 5.233426532540018 -0.40138548712898714 VSSS(ph)PQKEGR ddPTM_A459_Selumetinib_30min_R2 1 VSSSPQKEGR 10 1 Q7Z5J4-3;Q7Z5J4;A0A1W2PQJ7;Q7Z5J4-2 Q7Z5J4-3 RAI1 Retinoic acid-induced protein 1 1 VS(0.001)S(0.142)S(0.857)PQKEGR 112.94 0.03766 2533700.0 11039.0 13079.0 10970.0 15744.0 12184.0 7060.0 9961.2 17731.0 7271.5 23420.0 True False 10425.49657261828 14082.117244386636 10264.202143232913 13599.640040085125 10653.336993657997 8032.450915700957 10424.415537743347 17782.59427447493 8726.003182685536 22743.80374753226 0.4583884335420131 0.6191628014691505 0.4512966369728984 0.5979492344837309 0.46840612555030076 0.35317095613667926 0.4583409025798692 0.7818654466012253 0.3836650755321577 1.0 14.47318593495771 -14.462809424975381 0.42881905981835006 9.999999999948567 0.5060973258569947 0.5967086749926712 0.12089787022586411 684.2289230643543 4.555178396051123 5805.660482141574 0.06819070958895487 3.4450106990944285e-15 14.462809424975381 -9.493902674091572 VSSSSPQSGCPS(ph)PTIPAGK ddPTM_A459_Selumetinib_30min_R2 1 VSSSSPQSGCPSPTIPAGK 19 0 E7EWD6;Q76L83;A0A5F9ZHC8 E7EWD6 ASXL2 Putative Polycomb group protein ASXL2 1 VSSSSPQS(0.007)GCPS(0.924)PT(0.069)IPAGK 219.06 1.5746999999999999e-40 0.0 9653.1 9169.1 10339.0 14262.0 9722.3 10659.0 9656.0 11987.0 8418.6 9747.3 True False 9116.619346421012 9872.340486696648 9673.799996252057 12319.490996677725 8500.89775553522 12127.180497231802 10105.02313300102 12021.880185445327 10102.555235337484 9465.870122473152 0.9631042079034049 1.0429406234149026 1.021966271572357 1.3014641905375104 0.8980577216407218 1.2811479917139754 1.0675218445064483 1.2700237833291088 1.067261129154177 1.0 13.208519412215932 -5.562366394508195 24.998117493256252 1.1344851221582635 1.0103794611687114 0.15617045398581864 0.1241149562754671 246.00545335498822 155735.5191511511 0.03109878510250017 0.053864806500105944 2.7392622058383998e-06 5.562366394508195 -0.12410566098955211 VST(ph)PVVK ddPTM_A459_Selumetinib_30min_R1 1 VSTPVVK 7 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 VS(0.009)T(0.991)PVVK 105.57 0.04091 309360000.0 10429.0 11737.0 12005.0 13604.0 10254.0 9761.8 10601.0 9623.6 6213.0 8815.7 True False 10671.975408698529 10362.826583616728 10374.786938744746 11228.316778707258 9326.527510490743 9663.60515500524 9801.358035085934 9368.35086614165 10543.00722043395 9947.280967189765 1.072853520866567 1.0417747943179252 1.0429771686318172 1.1287825100892273 0.9375956647101331 0.9714820750393797 0.9853303699186596 0.9418001659993657 1.059888350918119 1.0 13.280086511702173 -6.269308054067286 24.99591512026548 0.9793451248528511 1.067422568235107 0.5532016827400086 0.03900519985955292 450.7643903947061 1431910.7106622665 0.011742455722404321 0.013555854940183465 5.378881119950628e-07 6.269308054067286 0.08807744338225598 VST(ph)PVVK ddPTM_A459_Selumetinib_30min_R2 1 VSTPVVK 7 0 Q9BTA9-5;Q9BTA9;A0A0A0MRT2;Q9BTA9-2 Q9BTA9-5 WAC WW domain-containing adapter protein with coiled-coil 1 VS(0.14)T(0.86)PVVK 111.95 0.034548 495150000.0 195040.0 192880.0 193990.0 222460.0 207400.0 176270.0 199000.0 171060.0 142920.0 216010.0 True False 184200.45760698157 207673.2757930495 181508.89460034246 192160.56423509502 181344.55782047517 200549.59248025608 208253.89431101907 171557.75627949237 171507.99351845117 209773.23003861832 0.8780932513317885 0.9899894078706696 0.8652624291809183 0.9160394975074709 0.8644790271241495 0.9560304355485959 0.9927572468263965 0.817824830403333 0.8175876087090679 1.0 17.678471056285716 -11.030210094521166 5.564349688522794 1.000176240210126 0.902840414057903 0.19624704853278185 0.06056004576422189 0.0001365322683922911 1.2088631861300729e-05 0.06046442028586607 0.014638297237163457 9.328029384025454e-12 11.030210094521166 -0.09733582615222292 VSTFSGRS(ph)PPAPPPYK ddPTM_A459_Selumetinib_30min_R2 1 VSTFSGRSPPAPPPYK 16 1 Q9UMN6;A0A669KBI7 Q9UMN6 KMT2B Histone-lysine N-methyltransferase 2B 1 VS(0.014)T(0.071)FS(0.369)GRS(0.546)PPAPPPYK 82.01 0.011385 10474000.0 118510.0 128850.0 125880.0 162720.0 139320.0 102550.0 87921.0 76144.0 68017.0 129920.0 True False 111923.68863311819 138732.38068194935 117781.01784778126 140557.25529234298 121817.3760633973 116675.33164378665 92009.5007121564 76365.5664336822 81622.30055376764 126168.87202730135 0.8870943112568948 1.0995769277538554 0.9335188303997435 1.1140406744852895 0.9655105423866955 0.9247552884402389 0.7292567432341529 0.6052647155088907 0.6469289868590218 1.0 16.944996491641675 -7.143047388578336 2.5962137895338295 0.7086407958341991 1.0067566941375181 0.49860715493903796 0.11870219292466298 0.20525790068748212 2.69214673250011 0.04926219940972952 0.0358916632837212 7.193704787234763e-08 7.143047388578336 0.29811589830331897 VSTGDT(ph)SPCGTEEDSSPASPMHER ddPTM_A459_Selumetinib_30min_R1 1 VSTGDTSPCGTEEDSSPASPMHER 24 0 B0QY16;Q6ICG6-3;Q6ICG6;Q6ICG6-2 B0QY16 KIAA0930 Uncharacterized protein KIAA0930 1 VS(0.099)T(0.099)GDT(0.398)S(0.398)PCGT(0.008)EEDSSPASPMHER 74.516 0.00061422 3813100.0 592.43 464.5 634.0 615.29 861.75 509.19 545.26 656.51 303.35 584.11 True False 606.2324663318892 410.1161240598086 547.9062823127174 507.8411519237569 783.8048646543194 504.0680109075289 504.1305992086558 639.0972221549782 514.7627941926024 659.0862082132122 0.9198075438043076 0.622249591857849 0.8313120127306192 0.7705231054682788 1.1892296559796334 0.7647982989570684 0.7648932611947042 0.9696716669092131 0.7810249824345867 1.0 9.364323371286376 -4.346207111882415 0.0279951343780541 1.5843845135470458 3.304786779453555e-10 0.08616546576114303 0.14600624448110996 2258.4209752529882 8.727249598424217 194.76897537103855 309.2186525688497 4.506017645868602e-05 4.346207111882415 -1.584384513216567 VSTGDTSPCGTEEDSSPAS(ph)PMHER ddPTM_A459_Selumetinib_30min_R2 2 VSTGDTSPCGTEEDSSPASPMHER 24 0 B0QY16;Q6ICG6-3;Q6ICG6;Q6ICG6-2 B0QY16 KIAA0930 Uncharacterized protein KIAA0930 1 VSTGDTSPCGTEEDS(0.011)S(0.002)PAS(0.987)PMHER;VSTGDTSPCGTEEDSSPAS(1)PMHER 194.59 2.9826e-27 7946500.0 28472.0 27685.0 37575.0 36570.0 40908.0 31309.0 26617.4 33740.0 29130.0 42828.0 True False 26889.640222446567 29808.35047869441 35157.465408566706 31589.102913231265 35768.77131783991 35621.530555195626 27855.161841377507 33838.17781404232 34956.81396020488 41591.444359492394 0.6465185481424512 0.716694285032476 0.845305229236232 0.759509639535317 0.8600031056549837 0.8564629361583049 0.6697329768260413 0.8135850614266885 0.8404808849160995 1.0 15.343999166339312 -14.522878745280336 0.12298916712524198 1.6965584924510348 0.6822819545269169 0.5270270460450723 0.06869139645651802 137.52084919439267 1.083799031651487 23.907334010891113 0.6575174978274874 3.0000000000000132e-15 14.522878745280336 -1.0142765379241179 VSTLAGPS(ph)SDDENEEESKPEKEDEPQEDAK ddPTM_A459_Selumetinib_30min_R1 1 VSTLAGPSSDDENEEESKPEKEDEPQEDAK 30 2 A0A087X2H1;Q9ULT8;H0YJP0;G3V4V5 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 VS(0.001)T(0.001)LAGPS(0.468)S(0.468)DDENEEES(0.062)KPEKEDEPQEDAK 66.447 0.00017943 23356000.0 3138.3 3786.0 4485.4 3847.1 2877.8 3844.5 3514.9 3351.9 2602.9 3688.6 True False 3211.416283931212 3342.733359936352 3876.3073165385827 3175.2762040109315 2617.503498116855 3805.827820526711 3249.768263137776 3262.9967234943433 4416.931191705705 4162.0677400066015 0.7715915464475641 0.8031424687794846 0.9313417173100682 0.7629083432471705 0.6288949775989718 0.9144079477477881 0.7808061920521797 0.7839845306047729 1.06123481587032 1.0 12.02308473060422 -8.259013254615631 24.983949854236272 1.0306174275974656 0.7984244892172555 0.575767762255208 0.08016036695097205 145.03094875270105 1493553.2583076935 0.061436482638854414 0.020706571583830383 5.5079088607693054e-09 8.259013254615631 -0.23219293838021005 VSTLAGPS(ph)SDDENEEESKPEKEDEPQEDAK ddPTM_A459_Selumetinib_30min_R2 2 VSTLAGPSSDDENEEESKPEKEDEPQEDAK 30 2 A0A087X2H1;Q9ULT8;H0YJP0;G3V4V5 A0A087X2H1 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 VST(0.001)LAGPS(0.498)S(0.498)DDENEEES(0.003)KPEKEDEPQEDAK;VS(0.001)T(0.002)LAGPS(0.413)S(0.413)DDENEEES(0.172)KPEKEDEPQEDAK 76.90899999999998 1.4920999999999997e-05 103525000.0 122748.0 107537.0 111975.0 91915.0 94630.0 78604.0 123554.0 106533.0 74905.0 93143.0 True False 115926.15755917634 115784.74211404585 104770.65040916202 79396.01843778117 82741.73339706642 89430.98750393167 129299.50581760624 106842.99339251244 89888.09302056806 90453.7195754226 1.2816074131977975 1.2800440120928538 1.158279072446563 0.8777529416198165 0.9147410829034429 0.9886933110513145 1.4294548242407328 1.1811896060661613 0.9937467850132696 1.0 16.464892209125452 -5.4432436433377065 4.437398033834471 1.0663940498057007 1.2754345012924535 0.2657789433121024 0.14846469248517458 0.3496689598322019 12.455782253764294 0.04455383812648836 0.09557295455701341 3.603764117032836e-06 5.4432436433377065 0.20904045148675277 VSTNGS(ph)DDPEDAGAGENRR ddPTM_A459_Selumetinib_30min_R1 1 VSTNGSDDPEDAGAGENRR 19 1 A0A590UK95;A0A590UK44;A0A590UJW8;A0A590UJQ1;Q96J02-2;Q96J02;Q96J02-3 A0A590UK95 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 VS(0.002)T(0.011)NGS(0.986)DDPEDAGAGENRR 142.97 0.000112 0.0 444.22 433.54 380.89 624.05 427.68 317.69 517.7 343.18 179.76 325.6 True False 454.5694616983473 382.7809352527219 329.16723007900765 515.0713823693226 388.9964195130367 314.4943270394409 478.6494721973388 334.07775159425677 305.0395908490596 367.3939316125761 1.2372808110986968 1.0418814855558685 0.8959517339718086 1.4019594175346237 1.0587992507269848 0.8560139402930617 1.3028235662370269 0.9093175549414031 0.8302793394277662 1.0 8.521183986869753 -7.947215080710786 24.93430694554141 0.9000251987474612 1.1018173757787977 0.23359035870410438 0.1649064532765956 130.86629442080425 61817.646678190365 0.08891789195609057 0.042714760356965774 1.1292365312193263e-08 7.947215080710786 0.20179217703133645 VSTTTDSPVS(ph)PAQAASPFIPLDELSSK ddPTM_A459_Selumetinib_30min_R1 1 VSTTTDSPVSPAQAASPFIPLDELSSK 27 0 Q96E09 Q96E09 FAM122A Protein FAM122A 1 VS(0.041)T(0.041)T(0.037)T(0.033)DS(0.188)PVS(0.613)PAQAAS(0.044)PFIPLDELS(0.001)SK 59.332 0.0038545 9470900.0 3334.4 4145.7 4635.2 4604.2 4201.2 4010.7 4140.1 4198.8 1814.9 3394.6 True False 3412.085032387036 3660.3195167163576 4005.7652993310853 3800.162901538075 3821.2022017821014 3970.355999424236 3827.8089237863696 4087.434184375448 3079.752744948586 3830.329976204087 0.8908070723892206 0.9556146701344482 1.0458016213268542 0.992124157747916 0.9976169743915819 1.0365571697712888 0.9993418184768991 1.0671232530274466 0.8040437153147484 1.0 11.903252967811538 -3.3245095353460004 14.258863732085763 0.9850353066384491 0.6254809032531952 0.0 0.0749834227930795 0.0 0.0 0.016477493535241014 0.0 0.00047368590783845497 3.3245095353460004 -0.3595544033852539 VSTVTS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 2 VSTVTSPSR 9 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 VST(0.008)VT(0.223)S(0.764)PS(0.005)R;VST(0.002)VT(0.224)S(0.773)PS(0.001)R 105.17 0.010834 16445000.0 13446.7 23219.0 17822.0 22327.0 17420.4 16056.4 16427.2 13173.4 7552.5 11647.8 True False 13759.9819472765 20500.50868577976 15401.870289238566 18428.008579696925 15844.727895821425 15894.887194044755 15188.083078385398 12823.998638766194 12816.040887224759 13142.908589179868 1.046951049983308 1.5598152073169838 1.1718768478629173 1.4021255991134345 1.2055724034226243 1.209388856826601 1.1556104933187512 0.9757352074504861 0.9751297287250245 1.0 13.681996965927429 -7.411157194988326 1.1649291031507563 0.9654029306099783 1.298832490095544 0.48384492153911784 0.13023770258534004 0.38603135793155635 0.9940612617219904 0.08853932804182447 0.04455602273626036 3.880098985112425e-08 7.411157194988326 0.33342955948556563 VSTVTS(ph)PSR ddPTM_A459_Selumetinib_30min_R2 1 VSTVTSPSR 9 0 Q8WYP5;Q8WYP5-3;Q8WYP5-2 Q8WYP5 AHCTF1 Protein ELYS 1 VS(0.001)T(0.011)VT(0.036)S(0.944)PS(0.008)R 82.831 0.040344 28160000.0 136560.0 138630.0 170080.0 182670.0 190540.0 119020.0 120050.0 134850.0 121220.0 153040.0 True False 128970.54189299331 149262.47523429344 159137.23796910208 157790.03087667402 166602.6617507875 135413.92464401256 125632.56287456218 135242.39117438064 145467.3871697915 148621.33755432718 0.8677794455042452 1.004313900618287 1.0707563300655325 1.0616916350856773 1.1209875008014067 0.9111338040172948 0.8453198238014669 0.9099796395315309 0.978778616607573 1.0 17.18128173280261 -6.797411646342342 24.88545168295099 0.9181833365116092 1.0285193935495933 0.2947530322563575 0.07324602626424376 200.61230258460728 138781.3369209941 0.027024870998532582 0.023834481801150005 1.5943672086789303e-07 6.797411646342342 0.1103360570379841 VSVGAPDLSLEASEGS(ph)IKLPK ddPTM_A459_Selumetinib_30min_R1 2 VSVGAPDLSLEASEGSIKLPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VSVGAPDLSLEAS(0.009)EGS(0.991)IKLPK;VSVGAPDLS(0.001)LEAS(0.025)EGS(0.975)IKLPK 101.33 0.00013518 84508000.0 11037.3 8468.6 13371.099999999999 14704.800000000001 8958.1 10742.3 7389.200000000001 9042.6 4934.6 6724.6 True False 11294.447615152785 7477.092375054666 11555.378062194912 12136.882723282451 8147.841436681013 10634.24221522801 6831.826694920955 8802.760873495617 8373.655791075711 7587.7679131508885 1.488507258580958 0.985413953172658 1.5228955595976363 1.5995326770929796 1.0738126850927296 1.4014980870457392 0.9003737031914538 1.1601252139300333 1.1035729989266996 1.0 12.88945983641267 -7.25002571871699 24.790820194898757 1.0543617430957661 1.3362107139117925 0.3778546693113082 0.19074398355937425 777.9519141240484 1689737.8445916406 0.0734247301955549 0.056368298617721094 5.6230802458495744e-08 7.25002571871699 0.28184897081602633 VSVGAPDLSLEASEGS(ph)IKLPK ddPTM_A459_Selumetinib_30min_R2 1 VSVGAPDLSLEASEGSIKLPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 VSVGAPDLSLEAS(0.023)EGS(0.977)IKLPK 84.156 0.00066497 5133700.0 11704.0 14765.0 11552.0 15748.0 9786.1 5171.5 12281.0 8188.6 6296.0 9946.5 True False 11053.538534824203 15897.428023042181 10808.756896866596 13603.095233184735 8556.682629155981 5883.827182797096 12852.090834339842 8212.4274703043 7555.375924938207 9659.318700889396 1.1443393553011594 1.6458125583513878 1.1189978539450576 1.408287235820494 0.8858474281802206 0.6091348018422182 1.3305380257467296 0.8502077345836128 0.7821851787789686 1.0 13.237705719943527 -6.265493384148298 24.59892425397599 0.9081809852155195 1.3369372529719912 0.46760771166512183 0.21933211868348937 245.77697012237715 1491325.374674993 0.06592454628763779 0.07753199694345067 5.426335175071168e-07 6.265493384148298 0.4287562677564717 VSVHVIEGDHR ddPTM_A459_Selumetinib_30min_R1 1 VSVHVIEGDHR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 121.61 0.0024771 5878600.0 4847.7 6793.2 5886.6 6736.3 9479.1 5889.0 7147.0 5697.8 2199.6 3753.9 False True 4960.641978017826 5997.848985926997 5087.232052779246 5559.931661011888 8621.717078671032 5829.7620067841835 6607.896035917288 5546.67583493722 3732.5605475722687 4235.749631082463 1.1711367314101881 1.4160064943201618 1.2010228403134355 1.3126204675112076 2.0354642813172408 1.3763235588819174 1.5600298911502506 1.3094909562725372 0.8812042430889377 1.0 12.048401600935044 -8.137072192369724 3.932072368831278 0.9432645823679893 1.4442527868725812 0.4199894658602715 0.23010871933719193 0.23582290760107938 6.062123054505511 0.1832648329480399 0.06244775483171734 7.2933626328552385e-09 8.137072192369724 0.5009882045045919 VSVQIDLNSLTSEGPSDDSASPR ddPTM_A459_Selumetinib_30min_R1 1 VSVQIDLNSLTSEGPSDDSASPR 23 0 H0YNN7;Q9UPX6 H0YNN7 KIAA1024 UPF0258 protein KIAA1024 0 47.822 0.034708 39094000.0 2048.8 1443.2 4524.8 4712.2 2966.4 2165.1 2460.1 2598.5 1865.3 1418.8 False True 2096.5330537291748 1274.2294730745223 3910.3570129472896 3889.30272894916 2698.089643760458 2143.3210597535117 2274.532676362126 2529.5793388824422 3165.2778638782306 1600.9168002823196 1.3095827674239247 0.7959373484304828 2.442573538023777 2.4294221462747387 1.6853403270455112 1.3388085248249877 1.4207688219406625 1.5800816997087883 1.9771657486010752 1.0 10.644682617538695 -6.539706575839733 21.066193675318992 1.4986366883004272 1.7678634730596918 0.06409054578723017 0.5063028235845676 138.11682763167906 172896.60186036615 0.1821937819314334 0.18230688552144125 2.885980711549653e-07 6.539706575839733 0.26922678475926465 VSVS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 1 VSVSPGR 7 0 A9Z1X7;Q8IYB3;Q8IYB3-2;E9PCT1;M0R088 A9Z1X7 SRRM1 Serine/arginine repetitive matrix protein 1 1 VS(0.092)VS(0.908)PGR 93.598 0.025499 419640000.0 241760.0 203870.0 270010.0 240100.0 297790.0 190910.0 212440.0 208500.0 175410.0 250420.0 True False 228323.94704195968 219506.17345462998 252637.85056466036 207397.96580439815 260378.9579236226 217206.11959156813 222318.88094187423 209106.700480967 210496.9013649003 243189.72393070094 0.9388716897718203 0.9026128649958096 1.0388508464965063 0.8528237231911083 1.0706824026734776 0.8931550070489941 0.9141787627721719 0.8598500672690997 0.8655665953421751 1.0 17.89172274290813 VSVT(ph)PPEESQNSDTPPRPDR ddPTM_A459_Selumetinib_30min_R1 2 VSVTPPEESQNSDTPPRPDR 20 1 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 VS(0.086)VT(0.889)PPEES(0.019)QNS(0.004)DT(0.002)PPRPDR;VS(0.058)VT(0.938)PPEES(0.002)QNS(0.001)DT(0.001)PPRPDR 74.859 0.008731299999999999 15420000.0 5115.5 5839.6 5493.5 5919.200000000001 4900.5 4945.5 5267.1 5841.700000000001 3581.1000000000004 4216.4 True False 5234.681196969731 5155.896917243611 4747.5128736355055 4885.522837145251 4457.250640253545 4895.752760154727 4869.798406433462 5686.759139484145 6076.865146804447 4757.616011213961 1.1002739995475257 1.083714386594227 0.9978764285401255 1.0268846467705268 0.936866411611942 1.0290348671719554 1.0235795396171277 1.1952959478192737 1.2772920581402416 1.0 12.216023120722596 -7.757771582837072 24.982003451800445 1.1772205232687447 1.025733352318665 0.363174576287735 0.07704314820155483 83.33315792077175 567609.1371176912 0.037219000161525684 0.020408083412088208 1.746740609512051e-08 7.757771582837072 -0.1514871709500798 VSVT(ph)PPEESQNSDTPPRPDR ddPTM_A459_Selumetinib_30min_R2 1 VSVTPPEESQNSDTPPRPDR 20 1 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 VS(0.036)VT(0.482)PPEES(0.036)QNS(0.022)DT(0.423)PPRPDR 62.765 0.030877 16470000.0 28732.0 24873.0 32067.0 44861.0 42278.0 32122.0 24870.0 37559.0 25216.0 32540.0 True False 27135.190463309034 26780.679120699493 30003.84413190973 38750.8544104585 36966.659669884495 36546.51392551645 26026.50427897008 37668.290471772816 30259.904593907508 31600.485650926526 0.8586953619338895 0.8474768209745626 0.9494741461680674 1.2262740148527536 1.1698130237058757 1.1565174766371005 0.8236108953030278 1.1920161888609577 0.9575772008117948 1.0 14.947659110129022 -5.540483044867998 10.492380545191928 1.0806510946703405 0.8643173704489797 0.37570711298891557 0.11634067283144205 0.3417221979281407 197.54276377751424 0.03183669524381438 0.05583325661146843 2.8808255168348232e-06 5.540483044867998 -0.21633372422136077 VSVTPPEES(ph)QNSDTPPRPDR ddPTM_A459_Selumetinib_30min_R2 1 VSVTPPEESQNSDTPPRPDR 20 1 Q05209-2;Q05209-3;Q05209;H3BM04 Q05209-2 PTPN12 Tyrosine-protein phosphatase non-receptor type 12 1 VS(0.015)VT(0.356)PPEES(0.443)QNS(0.135)DT(0.052)PPRPDR 59.57899999999999 0.017596 21365000.0 20584.0 20489.0 32569.0 31272.0 32398.0 24998.0 20822.0 26152.0 23515.0 22659.0 True False 19440.02368428071 22060.440417481295 30473.545998446018 27012.69965279103 28327.87359820518 28441.247590749645 21790.264258010273 26228.09799030335 28218.657063996478 22004.775794847723 0.8834456604112488 1.002529660976896 1.3848605540248768 1.2275834984474543 1.2873511578717367 1.2925034027117412 0.9902515917981916 1.1919275267710063 1.282387847396459 1.0 14.42552905183591 -5.05563465463358 6.056816807169421 1.2126690951796348 0.9096059967084157 0.4518516733533786 0.11944320980257235 0.1583181745311582 12.901384498976006 0.030453940667337625 0.08680348655289562 8.797622957950482e-06 5.05563465463358 -0.30306309847121915 VSVTTNT(ph)TDSVSDEEKVSGGK ddPTM_A459_Selumetinib_30min_R1 1 VSVTTNTTDSVSDEEKVSGGK 21 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 VS(0.001)VT(0.004)T(0.011)NT(0.318)T(0.318)DS(0.318)VS(0.032)DEEKVSGGK 62.468 0.020768 7358000.0 916.8 1029.4 1237.3 1101.7 915.61 868.6 979.09 1127.6 406.78 1047.9 True False 938.1596562177405 908.8773694449231 1069.2814560024049 909.3087764702871 832.7932371640753 859.8626726256989 905.2364530301184 1097.6923850389996 690.2759499642883 1182.4081724103767 0.793431302411647 0.7686663460657142 0.904325156872555 0.7690312006357604 0.7043195882741573 0.7272130662568421 0.7655871078637465 0.9283531784132706 0.5837882095800631 1.0 10.207512430719527 -10.905007242570784 5.382369119482901 1.0001055913608403 0.7765188562797354 0.3555048431297342 0.09203274966982215 0.00011257376877254647 1.2923102155564384e-05 0.08602394092771438 0.020854053211883276 1.2444938576278569e-11 10.905007242570784 -0.22358673508110494 VT(ph)NDISPESSPGVGR ddPTM_A459_Selumetinib_30min_R1 2 VTNDISPESSPGVGR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 VT(0.901)NDIS(0.001)PES(0.098)S(0.001)PGVGR;VT(0.804)NDIS(0.012)PES(0.183)S(0.001)PGVGR 191.51 6.342899999999999e-05 430700000.0 5872.2 6462.9 6669.700000000001 6677.8 6013.2 5267.9 6184.6 5609.1 3012.0 4377.799999999999 True False 6009.010834687843 5706.220663479304 5763.991374039639 5511.647587830887 5469.307121716685 5214.909708870507 5718.090642749972 5460.328447075432 5111.144012223895 4939.733273383095 1.2164646352600386 1.1551677687186663 1.1668628759973574 1.115778379680833 1.107206972325228 1.0557067396675348 1.1575707282741199 1.1053893287108183 1.0347004037170218 1.0 12.27021742858615 -1.5228787452850947 0.09754449830786466 0.937428627137998 1.6824864274624205 0.7344529654454222 0.03243989648396648 76.15810524656011 0.5304328483492857 0.47749478815580365 7.588382013770857 0.029999999999671387 1.5228787452850947 0.7450578003244225 VT(ph)NDISPESSPGVGR ddPTM_A459_Selumetinib_30min_R2 2 VTNDISPESSPGVGR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 VT(0.999)NDISPES(0.001)SPGVGR;VT(0.861)NDIS(0.01)PES(0.129)SPGVGR 215.37 2.8293e-07 299760000.0 102939.0 100708.0 110667.0 122199.0 122828.0 85039.0 82602.0 100324.0 87584.0 105956.0 True False 97218.06247746662 108431.97977274156 103546.80570511895 105555.28539496732 107397.24854374799 96752.3503428178 86443.15667275777 100615.92623046767 105103.24730142768 102896.77497325033 0.9448115599613304 1.053793763710575 1.0063173090899846 1.0258366739133282 1.0437377514666288 0.9402855470248715 0.840095879537819 0.9778336226439011 1.021443551838733 1.0 16.65083823992417 -6.771437628156959 24.934714558759552 0.9473065677624883 1.0171910514297322 0.22713358613917034 0.05312671990685381 271.97082042987387 678265.822102893 0.019186747666972724 0.017114635623358694 1.6926313167262976e-07 6.771437628156959 0.06988448366724387 VT(ph)PTKESYTEEIVSEAESHVSGISR ddPTM_A459_Selumetinib_30min_R1 1 VTPTKESYTEEIVSEAESHVSGISR 25 1 Q5QJE6;J3KP30;E9PRB3 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 1 VT(0.942)PT(0.046)KES(0.01)Y(0.002)TEEIVSEAESHVSGISR 102.29 1.2243e-06 2842400.0 616.15 652.97 602.08 755.98 969.87 742.6 1009.9 563.47 188.82 427.13 True False 630.505096180804 576.5199688424825 520.3208429887079 623.96228450214 882.145429744456 735.1301182268527 933.7224299248451 548.524945191491 320.4137491328405 481.95629609852494 1.3082204782566254 1.196207982984055 1.0796017132689149 1.2946449492478156 1.8303432010028593 1.5253045227913615 1.9373591287911442 1.1381217542583106 0.6648190961018989 1.0 8.912758518261919 -7.998459749379173 24.998469470469725 0.855429735287685 1.4470224973243209 0.4753504516572774 0.262890984547512 44.36461545044294 720048.6353361689 0.15974988540228377 0.07584055784781882 1.0035528545976447e-08 7.998459749379173 0.5915927620366359 VT(ph)SPTTYVLDEDEPR ddPTM_A459_Selumetinib_30min_R2 1 VTSPTTYVLDEDEPR 15 0 J3KNS1;Q9UPW5-2;Q9UPW5;Q9UPW5-3 J3KNS1 AGTPBP1 Cytosolic carboxypeptidase 1 1 VT(0.628)S(0.367)PT(0.004)T(0.001)YVLDEDEPR 183.28 4.8752e-05 1969300.0 10464.0 9017.4 10986.0 9707.6 12784.0 8600.3 9483.7 7796.7 8953.6 9449.5 True False 9882.452770710908 9709.005584489032 10279.172720652394 8385.408133455943 11177.95962958994 9784.913259249706 9924.710841595042 7819.387106186829 10744.570184486449 9176.668382250476 1.0769107435358087 1.0580098550001222 1.1201421139434855 0.913774780145157 1.2180847300977296 1.0662816669038295 1.0815156904646823 0.8520943310222583 1.1708574110914383 1.0 13.16375475847452 VTAEADSS(ph)SPTGILATSESK ddPTM_A459_Selumetinib_30min_R1 3 VTAEADSSSPTGILATSESK 20 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 VTAEADSS(0.916)S(0.084)PTGILATSESK;VTAEADSS(0.913)S(0.087)PTGILATSESK;VTAEADS(0.004)S(0.498)S(0.498)PTGILATSESK 292.35 7.057199999999997e-86 54142600.0 10364.400000000001 11253.5 11361.3 11561.5 11183.7 9502.8 10793.3 10929.0 5700.3 9352.4 True False 10605.87035438825 9935.934988389783 9818.497863153749 9542.501061233757 10172.136309642601 9407.210459852047 9979.152691264317 10639.12741760485 9672.992766560377 10552.871640090474 1.0050222078032707 0.941538505087379 0.9304100531132369 0.904256337676059 0.9639211635057272 0.8914360735815219 0.9456338550876907 1.0081736782608717 0.9166218538859672 1.0 13.36534801707764 -10.514130774186926 4.349367745914006 1.0000021419122516 0.9443062014949057 0.16610799477297156 0.03676741168368797 10475679.272811327 12661916.907392196 172.33720584707228 0.00886149005596716 3.0610415580663534e-11 10.514130774186926 -0.055695940417345824 VTAEADSSS(ph)PTGILATSESK ddPTM_A459_Selumetinib_30min_R1 1 VTAEADSSSPTGILATSESK 20 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 VTAEADS(0.006)S(0.072)S(0.921)PT(0.002)GILATSESK 349.02 2.0027999999999983e-194 35040000.0 7310.3 6939.7 7574.1 7380.6 7046.8 6478.6 7339.6 6815.7 4057.1 5444.1 True False 7480.6157666323625 6127.196697820998 6545.578821553239 6091.716761020791 6409.418184213588 6413.431166098156 6785.968062854143 6634.925495486264 6884.602381139962 6142.90326502465 1.217765516384433 0.9974431361644455 1.0655513426072116 0.9916673758652044 1.04338582388337 1.0440390950991836 1.1046841810924908 1.0800960407862843 1.1207408100235379 1.0 12.584704949395134 -7.245395170960763 23.657932781810167 1.0830549310781539 1.0535274786653825 0.0050402933232933655 0.0656343221764226 1506.367744894268 2221207.317003866 0.02418901279759044 0.018664820043002805 5.68335558581868e-08 7.245395170960763 -0.029527452412771327 VTAEADSSS(ph)PTGILATSESK ddPTM_A459_Selumetinib_30min_R2 4 VTAEADSSSPTGILATSESK 20 0 A0MZ66-7;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-7 KIAA1598 Shootin-1 1 VTAEADS(0.008)S(0.037)S(0.929)PT(0.025)GILAT(0.001)SESK;VTAEADSS(0.022)S(0.978)PTGILATSESK;VTAEADS(0.027)S(0.137)S(0.787)PT(0.033)GILAT(0.012)S(0.004)ESK;VTAEADSS(0.02)S(0.979)PT(0.001)GILATSESK 293.35 5.513099999999998e-86 49765200.0 175946.0 155576.0 177846.0 194695.0 193225.0 148427.0 149803.0 153019.0 134336.0 157414.0 True False 166167.62568764354 167508.17894431483 166403.5819840837 168177.2051323919 168950.3480465829 168871.4719638452 156769.13632901307 153464.2599563409 161206.95366145132 152869.04880931036 1.086993259799254 1.0957625513406928 1.0885367788979727 1.1001390172982433 1.1051965676670914 1.104680596099583 1.0255126040887956 1.0038936014298945 1.054542792783003 1.0 17.221936810177766 -7.273391507494863 11.620107351949256 1.0212928946330602 1.09698246182331 0.8633166840249912 0.014794474599696138 0.23044056111167205 221.44087375692263 0.005806611996306805 0.004038036954324579 5.328543217541089e-08 7.273391507494863 0.07568956719024977 VTAQGPGLEPSGNIANK ddPTM_A459_Selumetinib_30min_R2 2 VTAQGPGLEPSGNIANK 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 ; 218.16 1.5773e-38 2935700.0 18026.4 12006.0 13364.3 19697.6 19202.0 15436.0 15912.7 15515.0 13900.7 15558.0 False True 17024.564853396703 12926.821594625424 12504.455487949648 17014.752899744704 16789.673091941953 17562.16888594335 16652.67208041686 15560.146081353478 16681.228418009618 15108.800115461447 1.126797940491302 0.855582276278636 0.8276273027898048 1.1261485207109743 1.1112512551384144 1.162380119647706 1.1021836249839263 1.0298730516283785 1.1040736716702633 1.0 13.883101471143585 -5.7771669377339165 24.99995734236733 1.0963924723481857 0.9285604688119449 0.40056756973393304 0.08607026969318723 211.23514517523645 335771.21580260026 0.024254988557772788 0.03611308323095966 1.6704483900072103e-06 5.7771669377339165 -0.16783200353624084 VTDALPEPEPPGAMAAS(ph)EDEEEEEEALEAMQSR ddPTM_A459_Selumetinib_30min_R1 5 VTDALPEPEPPGAMAASEDEEEEEEALEAMQSR 33 0 Q9Y3E7-2;Q9Y3E7-4;Q9Y3E7;Q9Y3E7-3 Q9Y3E7-2 CHMP3 Charged multivesicular body protein 3 1 VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR 157.08 2.9904e-30 21681200.0 18532.809999999998 22326.56 21753.01 24072.469999999998 22824.0 19246.059999999998 19524.6 19493.4 10661.060000000001 16075.46 True False 18964.58841442921 19712.55597586385 18799.070722730845 19868.66501072678 20759.573229904487 19052.462110424323 18051.843702654347 18976.371708512983 18091.040166985276 18138.9018792405 1.0455202051748065 1.086755753303035 1.0363951934844462 1.0953620645286113 1.1444779495534554 1.0503646933682005 0.9952004714968005 1.0461698196973515 0.997361377630583 1.0 14.14679949796671 -7.002040286402876 24.98371100169412 1.0148521358541733 1.0819444588024179 0.5482723689552949 0.030673405065356298 67.19074323103258 822776.3140344766 0.011246154906122633 0.009765392319407836 9.953130849700659e-08 7.002040286402876 0.06709232294824452 VTDALPEPEPPGAMAAS(ph)EDEEEEEEALEAMQSR ddPTM_A459_Selumetinib_30min_R2 6 VTDALPEPEPPGAMAASEDEEEEEEALEAMQSR 33 0 Q9Y3E7-2;Q9Y3E7-4;Q9Y3E7;Q9Y3E7-3 Q9Y3E7-2 CHMP3 Charged multivesicular body protein 3 1 VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR;VT(0.007)DALPEPEPPGAMAAS(0.99)EDEEEEEEALEAMQS(0.003)R;VTDALPEPEPPGAMAAS(1)EDEEEEEEALEAMQSR 116.57 1.1464e-18 17256300.0 230505.4 221354.2 249442.7 257291.19999999998 269879.3 197379.1 201605.69999999998 209383.4 185287.3 232239.9 True False 217694.83265422645 238331.35537406613 233393.82825467628 222247.69470792392 235974.64958244632 224566.2793959253 210980.76452411604 209992.67102871204 222349.93735972102 225534.53065527361 0.9652394780601024 1.0567399798230999 1.0348474248114825 0.9854264624676317 1.0462905564697331 0.9957068602464769 0.9354698986054477 0.9310887801464109 0.9858797972696243 1.0 17.78298880987434 -7.042499635345524 5.6600963486518925 0.9579715005652877 1.0193227268236775 0.38859064979384284 0.03197988578871671 0.18475689918137456 15.124979656800216 0.011848652241728234 0.009365331925042741 9.067767259568137e-08 7.042499635345524 0.061351226258389846 VTDAPNKS(ph)EISK ddPTM_A459_Selumetinib_30min_R1 2 VTDAPNKSEISK 12 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 VTDAPNKS(0.982)EIS(0.018)K;VTDAPNKS(0.998)EIS(0.002)K 176.56 0.00049159 25958000.0 4807.5 5497.1 6275.3 6441.8 4444.3 5257.5 4792.3 4574.8 3114.3999999999996 4153.4 True False 4919.505396233407 4853.496976467544 5423.148727755512 5316.8605575622205 4042.3138497048944 5204.614323428058 4430.812952697134 4453.461442955316 5284.9093332238035 4686.529347541996 1.0497118510126482 1.0356271382389017 1.1571780150272313 1.1344985090834485 0.8625388960436189 1.1105476862441477 0.9454358703676996 0.9502685490044098 1.1276808361385058 1.0 12.194304201718996 VTDAPNKS(ph)EISK ddPTM_A459_Selumetinib_30min_R2 1 VTDAPNKSEISK 12 1 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 VTDAPNKS(0.992)EIS(0.008)K 115.1 0.02508 0.0 8161.7 9506.9 6790.2 8804.4 8386.9 9270.3 7972.5 6608.5 6030.1 9654.9 True False 7708.105387873778 10236.04866049846 6353.32592461077 7605.225531562846 7333.262642162696 10547.199677595265 8343.23704720905 6627.72964090393 7236.288495071452 9376.137950557186 0.8220981206249975 1.0917126768479524 0.6776058498833433 0.8111256011448614 0.7821197470464808 1.1248980905798733 0.8898372753478148 0.7068720272519103 0.7717770934291159 1.0 13.194778080864296 -10.611818160642803 4.691094656430959 1.0000059390315323 0.8564209033697286 0.08856568223732952 0.14100124699959876 33645034.81405065 76109099.15386364 1557.2201999634815 0.03504681240902759 2.4444538327248574e-11 10.611818160642803 -0.1435850356618037 VTENLASLT(ph)PK ddPTM_A459_Selumetinib_30min_R2 2 VTENLASLTPK 11 0 Q96DF8 Q96DF8 DGCR14 Protein DGCR14 1 VTENLAS(0.011)LT(0.989)PK;VT(0.004)ENLAS(0.046)LT(0.951)PK 104.9 0.028066000000000004 13825600.0 128156.0 106888.0 110357.0 110662.0 105285.0 85878.0 96831.0 100513.0 68211.0 93157.0 True False 121033.60256911584 115085.96590090952 103256.75076761651 95589.6446974021 92058.15704015779 97706.91497713405 101333.83336698642 100805.47618917716 81855.10597458071 90467.31535904628 1.3378710541896621 1.2721275683284825 1.1413707852146555 1.0566207731270276 1.017584711945942 1.0800244772308683 1.1201154026159963 1.1142750924917009 0.9048030844036273 1.0 16.465109039298405 -5.299942947484891 1.7048409513470875 1.049078696826172 1.3438816363926271 0.7608921030644933 0.05898417806115454 0.22065823328659082 1.1151451430030297 0.01754994757305632 0.07528357378001231 5.012530780523441e-06 5.299942947484891 0.2948029395664551 VTFFEPGS(ph)GDENGTSNKEDEFR ddPTM_A459_Selumetinib_30min_R1 1 VTFFEPGSGDENGTSNKEDEFR 22 1 O95793-2;O95793-3;O95793;Q5JW30 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 VTFFEPGS(1)GDENGTSNKEDEFR 145.83 2.527e-07 32027000.0 1978.6 2504.2 2941.0 2892.9 2238.0 2219.3 2261.8 2325.5 1585.4 2487.4 True False 2024.6975303145953 2211.0070998290043 2541.628353756628 2387.709321458559 2035.5732951509908 2196.975856963176 2091.1906050143734 2263.8201857114186 2690.308006965393 2806.6820193277717 0.7213847227337604 0.7877654414013606 0.9055633435687072 0.8507231332284798 0.7252596771324067 0.7827662135696346 0.7450757123941081 0.8065823524439103 0.9585368019743642 1.0 11.454649908852838 -8.302591665926446 3.447132481677626 0.9958772425536737 0.7912473609089681 0.6728015326177774 0.05307013335074129 0.152116829035367 3.5071037157415086 0.053435681317660036 0.01486136948422735 4.982052893814028e-09 8.302591665926446 -0.20462988164470564 VTFFEPGS(ph)GDENGTSNKEDEFR ddPTM_A459_Selumetinib_30min_R2 1 VTFFEPGSGDENGTSNKEDEFR 22 1 O95793-2;O95793-3;O95793;Q5JW30 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 VT(0.001)FFEPGS(0.876)GDENGT(0.062)S(0.062)NKEDEFR 54.658 0.014874 10614000.0 19767.0 16210.0 19166.0 21826.0 19454.0 12275.0 16567.0 15693.0 11783.0 17653.0 True False 18668.429273570582 17453.254876634866 17932.880426362997 18853.26114804992 17010.014599033373 13965.76982864437 17337.39832688771 15738.66403188399 14139.92924452777 17143.312021997743 1.0889628124143023 1.0180795201206987 1.0460569348182023 1.0997443856740183 0.9922245233130373 0.8146482902909279 1.011321400709555 0.9180643747070956 0.8248073199848355 1.0 14.065358239064807 -6.5262280676136015 24.978484038898085 0.9134879137306827 1.057164777816865 0.5587147098222245 0.0625982225497355 75.05317446694765 559721.0737654489 0.019933135912467537 0.02003106851224989 2.9769526867907305e-07 6.5262280676136015 0.1436768640861822 VTFFEPGSGDENGT(ph)SNKEDEFR ddPTM_A459_Selumetinib_30min_R2 1 VTFFEPGSGDENGTSNKEDEFR 22 1 O95793-2;O95793-3;O95793;Q5JW30 O95793-2 STAU1 Double-stranded RNA-binding protein Staufen homolog 1 1 VTFFEPGS(0.133)GDENGT(0.433)S(0.433)NKEDEFR 57.989 0.027909 8179700.0 17040.0 22096.0 17949.0 20207.0 14692.0 13950.0 14556.0 14861.0 13339.0 16435.0 True False 16092.985016524644 23790.69215016186 16794.180881393586 17454.771740980697 12846.25961185352 15871.485874508267 15232.882842166804 14904.243049629009 16007.172722800298 15960.478846741787 1.0083021425018153 1.4906001491940546 1.0522354023746594 1.0936245653145902 0.8048793357146667 0.9944241665248228 0.9544126456629767 0.9338217977508613 1.0029255936809216 1.0 13.962216315536805 -5.673695575693317 2.329335466290956 0.9525980007875734 1.2476417112060112 0.4052813368612064 0.1303233537103161 0.24559538294370498 2.6974135425420895 0.0354567713016383 0.07184185131030622 2.1198465482995243e-06 5.673695575693317 0.2950437104184378 VTFGEDLS(ph)PEVFDESLPANTPLRK ddPTM_A459_Selumetinib_30min_R1 1 VTFGEDLSPEVFDESLPANTPLRK 24 1 E9PEI0;Q69YH5 E9PEI0 CDCA2 Cell division cycle-associated protein 2 1 VT(0.02)FGEDLS(0.98)PEVFDESLPANTPLRK 114.05 9.3305e-08 13049000.0 1090.7 1259.5 1401.2 1372.6 1366.4 1149.2 1288.2 1084.4 522.77 867.61 True False 1116.1111878672443 1112.037154474336 1210.9247362406618 1132.9011768930889 1242.8093612575142 1137.640091390114 1191.0300368642302 1055.6381893723767 887.1025083898691 978.9761947370619 1.1400800079383082 1.135918483465282 1.2369297054928876 1.1572305669775442 1.2694990623253244 1.1620712510743603 1.2166077615238875 1.0783083337954966 0.9061532988839748 1.0 9.935129968753497 -8.006634510550619 3.6302230210284994 0.9567768973129535 1.1885396956980876 0.804734966162375 0.046341425867505046 0.09259846221650903 2.5843474690620125 0.031711932618420105 0.012083642382027426 9.848395690925606e-09 8.006634510550619 0.23176279838513414 VTFSVS(ph)PIEATEK ddPTM_A459_Selumetinib_30min_R1 4 VTFSVSPIEATEK 13 0 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTFS(0.035)VS(0.965)PIEATEK;VT(0.01)FS(0.412)VS(0.578)PIEATEK;VTFS(0.046)VS(0.951)PIEAT(0.002)EK;VT(0.002)FS(0.037)VS(0.96)PIEATEK 163.33 0.00036306 220206000.0 11552.5 16307.9 14848.900000000001 16407.7 14177.499999999998 12829.1 14777.2 14702.3 6972.900000000001 14010.300000000001 True False 11821.65077274809 14398.563486662979 12832.500939169257 13542.403205674445 12895.147628240928 12700.05090189081 13662.54390680803 14312.347244199089 11832.502019533862 15808.658476878623 0.7477959492918492 0.9108023623713538 0.8117387669508943 0.8566446814877587 0.8157015756334461 0.8033604445605306 0.8642443586715818 0.905348626838387 0.7484823609061961 1.0 13.948427325305724 -11.075163657085863 3.177582893418127 1.0062521101755055 0.8341234763806175 0.47328428187033256 0.05379664921526223 17483983.2143863 23254480.688495614 946417.0446685088 0.012359312007910508 8.410781347735031e-12 11.075163657085863 -0.17212863379488808 VTFSVS(ph)PIEATEK ddPTM_A459_Selumetinib_30min_R2 4 VTFSVSPIEATEK 13 0 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTFS(0.226)VS(0.773)PIEAT(0.001)EK;VTFS(0.018)VS(0.982)PIEAT(0.001)EK;VTFS(0.007)VS(0.862)PIEAT(0.131)EK;VTFS(0.01)VS(0.99)PIEATEK 195.94 9.893e-05 82383000.0 456857.0 385742.0 465617.0 504015.0 479245.0 391423.0 413576.0 405483.0 332130.0 445142.0 True False 431466.71688347403 415327.1710439782 435659.7091454581 435367.28752562904 419037.9585953406 445337.9652657811 432808.10348529695 406662.8883986753 398565.28048756724 432289.59384218574 0.9980964682693423 0.9607614362227744 1.0077959667576515 1.0071195183212458 0.969345467863187 1.0301843292308324 1.0011994497450256 0.9407186621918411 0.9219867564822065 1.0 18.72163858225756 -7.759462814453454 24.966271646053034 0.9485145247015017 0.9961044123717102 0.3468797263944814 0.026133912762741913 49.721517852798854 628067.4772916386 0.012709386262665715 0.006865611216249319 1.739951671342559e-08 7.759462814453454 0.04758988767020855 VTGTEGSSSTLVDYTS(ph)TSSTGGSPVRK ddPTM_A459_Selumetinib_30min_R2 1 VTGTEGSSSTLVDYTSTSSTGGSPVRK 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDYT(0.005)S(0.359)T(0.319)S(0.201)S(0.033)T(0.033)GGS(0.05)PVRK 80.93 5.0053e-05 14236000.0 14463.0 11995.0 15900.0 14461.0 13493.0 13590.0 9643.8 8887.7 9319.5 12675.0 True False 13659.204359976286 12914.977929995997 14877.01131061106 12491.38685338357 11797.88871104952 15461.899142262899 10092.255808827174 8913.561735562065 11183.660408586658 12309.039816395018 1.10968885987215 1.0492270820989547 1.2086248425970347 1.0148140748351204 0.9584735192208356 1.2561417765233347 0.8199060169896275 0.7241476076541448 0.9085729330155053 1.0 13.587430606347198 -7.2841214663307605 24.903273139860804 0.8401689008114284 1.0919113654374184 0.5433929839601369 0.10515604470102798 556.317869006271 610793.6255298943 0.04291140105982334 0.028953618896296402 5.198505809770631e-08 7.2841214663307605 0.25174246462599004 VTGTEGSSSTLVDYTST(ph)SSTGGSPVRK ddPTM_A459_Selumetinib_30min_R1 2 VTGTEGSSSTLVDYTSTSSTGGSPVRK 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDYT(0.001)S(0.014)T(0.699)S(0.145)S(0.058)T(0.058)GGS(0.024)PVRK;VTGTEGSSSTLVDYT(0.001)S(0.02)T(0.3)S(0.244)S(0.163)T(0.163)GGS(0.11)PVRK 138.54 3.9826e-12 70596000.0 2656.95 3286.05 3036.53 2997.0099999999998 2610.83 2592.02 2378.53 2324.0 1603.6 2150.13 True False 2718.85176547527 2901.3177383567995 2624.1859044653547 2473.6384643453 2374.6808874794756 2565.9466321658597 2199.11556713451 2262.3599705841043 2721.1920776899874 2426.1201295397696 1.1206583434889645 1.1958673039439205 1.0816388984675536 1.0195861425932542 0.9787977349373661 1.057633791881779 0.9064330905789394 0.9325012158459234 1.121622975118793 1.0 11.244435272053932 -5.60980033307509 2.420602129645472 0.9950013066870039 1.1583734136190813 0.5242150737255532 0.059594142223157065 0.21608289530586067 2.543446583364254 0.017196668920304185 0.03656942404276252 2.455837727783173e-06 5.60980033307509 0.16337210693207738 VTGTEGSSSTLVDYTSTS(ph)STGGSPVRK ddPTM_A459_Selumetinib_30min_R1 1 VTGTEGSSSTLVDYTSTSSTGGSPVRK 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDYT(0.001)S(0.01)T(0.115)S(0.358)S(0.244)T(0.244)GGS(0.027)PVRK 112.06 3.4234000000000003e-10 23694000.0 1051.4 1455.6 1261.2 1272.3 983.35 1173.6 1123.6 1097.9 998.82 1217.6 True False 1075.895574331733 1285.1776753099186 1089.935967275708 1050.1166890289073 894.4061661245436 1161.794649543542 1038.84594738445 1068.7801255181964 1694.9245890735301 1373.8908204283573 0.7831012176035108 0.9354292613362252 0.7933206562482769 0.7643378013847546 0.6510023597404064 0.8456237076984857 0.7561342807869947 0.7779221679237712 1.2336675985250993 1.0 10.424051646107053 -8.249697270570259 24.76634633978204 1.1168337938224973 0.7888820670883866 0.7032216894726406 0.08535506776908106 303.45226964102716 640042.3828092045 0.05845208393697961 0.021695797751881643 5.6273344763813015e-09 8.249697270570259 -0.32795172673411066 VTGTEGSSSTLVDYTSTS(ph)STGGSPVRK ddPTM_A459_Selumetinib_30min_R2 1 VTGTEGSSSTLVDYTSTSSTGGSPVRK 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDYT(0.001)S(0.011)T(0.042)S(0.319)S(0.23)T(0.23)GGS(0.167)PVRK 100.41 6.0917e-07 60978000.0 25874.0 21314.0 22995.0 24828.0 23097.0 20174.0 23217.0 14317.0 19861.0 17198.0 True False 24436.02666182855 22948.71526468819 21515.526735062962 21446.383569311085 20195.348370200158 22952.78537866164 24296.636503612728 14358.660099693052 23833.75496270611 16701.449054229714 1.463108175972313 1.3740553403584064 1.2882431138281418 1.2841031637239702 1.2091973759058707 1.3742990386123861 1.454762184090817 0.8597254078415825 1.4270471313787056 1.0 14.027685659054676 -12.373766353579697 0.05180619085296072 9.742161398020819e-10 1.939991616664651 0.2906991374307357 0.16048983430687644 428.3036914477939 2.4824636399382247 76.75727748606771 26.947642960957033 4.228960672548063e-13 12.373766353579697 1.9399916156904349 VTGTEGSSSTLVDYTSTSS(ph)TGGSPVR ddPTM_A459_Selumetinib_30min_R1 1 VTGTEGSSSTLVDYTSTSSTGGSPVR 26 0 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDY(0.002)T(0.004)S(0.026)T(0.13)S(0.13)S(0.307)T(0.095)GGS(0.307)PVR 69.913 0.0050739 0.0 1102.1 1681.5 1397.1 1785.8 1937.8 1352.3 1288.0 1365.8 830.17 1103.0 True False 1127.7767856867063 1484.6291982918588 1207.3814937209731 1473.943553617718 1762.526332146377 1338.6970897901595 1190.8451230252515 1329.5745472563542 1408.7378567821743 1244.580794129827 0.9061499189172476 1.1928749063895578 0.9701109798702443 1.1842891683446348 1.4161606385535475 1.075620880624416 0.9568242806268389 1.068291069191657 1.131897473773184 1.0 10.281444173082251 -10.333053722589668 9.580460117110803 0.9999999528652002 1.105024408013967 0.04369306379403792 0.13908932625522152 0.0 0.0 0.13945676282226555 0.033823233136641824 4.644578178495759e-11 10.333053722589668 0.1050244551487669 VTGTEGSSSTLVDYTSTSSTGGS(ph)PVRK ddPTM_A459_Selumetinib_30min_R1 1 VTGTEGSSSTLVDYTSTSSTGGSPVRK 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDYT(0.001)S(0.019)T(0.057)S(0.204)S(0.143)T(0.143)GGS(0.433)PVRK 103.92 8.8206e-08 39682000.0 1804.9 1885.6 2018.1 2581.8 1931.6 1592.2 2206.9 1801.0 917.21 1780.3 True False 1846.950658275959 1664.833075408341 1744.0531046298017 2130.937096388299 1756.887121051678 1576.1839136019325 2040.4317562146161 1753.2316295275273 1556.438379632098 2008.8188465905087 0.9194212118283924 0.8287621744658552 0.8681982985125395 1.0607910713328168 0.8745871356362348 0.7846321813821735 1.0157370634379317 0.8727674137980238 0.7748027564923444 1.0 10.972131753706279 VTGTEGSSSTLVDYTSTSSTGGS(ph)PVRK ddPTM_A459_Selumetinib_30min_R2 1 VTGTEGSSSTLVDYTSTSSTGGSPVRK 27 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 VTGTEGSSSTLVDY(0.001)T(0.02)S(0.04)T(0.094)S(0.221)S(0.082)T(0.082)GGS(0.459)PVRK 61.438 0.0019804 71704000.0 22263.0 14202.0 21740.0 23764.0 24829.0 15494.0 17366.0 18218.0 16237.0 17738.0 True False 21025.71158585024 15291.2477333725 20341.2720687223 20527.302204813437 21709.759045923714 17628.157859471765 18173.553410076183 18271.011363847752 19484.85369968578 17225.85785114121 1.2205901016684224 0.8876915080522076 1.1808568400194186 1.1916563100776725 1.2603006035188806 1.0233544251791156 1.0550158701601144 1.0606735247520518 1.1311398171322373 1.0 14.072288210767546 VTIPPPSSSVAISNHVT(ph)PPPIPK ddPTM_A459_Selumetinib_30min_R1 2 VTIPPPSSSVAISNHVTPPPIPK 23 0 F5H2U7;A0A1W2PRW5;A0A1W2PNT6;F5GYH1;A0A1W2PRM0;A0A1W2PRL5;A0A1W2PR09;Q8NC96 F5H2U7 NECAP1 Adaptin ear-binding coat-associated protein 1 1 VTIPPPSSSVAIS(0.001)NHVT(0.999)PPPIPK;VTIPPPSSS(0.001)VAIS(0.36)NHVT(0.638)PPPIPK 114.21 1.5429e-05 26077000.0 3099.7 4146.1 4158.6 4563.7 6098.700000000001 3892.8999999999996 5582.8 3992.2 1375.27 2019.44 True False 3171.9169790337373 3660.672684530402 3593.8849615546787 3766.7354662589187 5547.073661812936 3853.7409604703953 5161.684901261936 3886.3138875068216 2333.732744253371 2278.6547950113677 1.3920129481560692 1.6065060370463617 1.5771958830371011 1.6530522633377327 2.434363324342537 1.6912350957711302 2.2652333791684254 1.705529901244841 1.0241712563757288 1.0 11.153966664619622 -8.239636058746497 4.616057362227347 0.994582315272975 1.8114582632134617 0.517597323583378 0.30148453252248925 0.15451163651986324 8.551052623789147 0.2543005545360617 0.0810408422837938 5.759223613963798e-09 8.239636058746497 0.8168759479404867 VTIPPPSSSVAISNHVT(ph)PPPIPK ddPTM_A459_Selumetinib_30min_R2 2 VTIPPPSSSVAISNHVTPPPIPK 23 0 F5H2U7;A0A1W2PRW5;A0A1W2PNT6;F5GYH1;A0A1W2PRM0;A0A1W2PRL5;A0A1W2PR09;Q8NC96 F5H2U7 NECAP1 Adaptin ear-binding coat-associated protein 1 1 VTIPPPSSSVAIS(0.019)NHVT(0.981)PPPIPK;VTIPPPSSSVAIS(0.005)NHVT(0.995)PPPIPK 98.766 7.8067e-05 14952400.0 91897.0 70903.0 117737.0 156948.0 165982.0 97017.0 78484.0 97358.0 96165.0 117941.0 True False 86789.73263283834 76341.03211092192 110161.92960235295 135571.41164959874 145129.85726209308 110380.21111735974 82133.66151309566 97641.29566151544 115400.68707460006 114535.73688248068 0.757752427278561 0.6665258738349201 0.9618127285057285 1.1836603608592635 1.267114188220603 0.9637185224609441 0.7171007385875454 0.852496332753333 1.0075517931403966 1.0 16.8054382856756 -5.309482355580453 6.088413401445312 0.9956137916925355 0.7121973702957517 0.3744534453775886 0.1460238472691201 0.22950955947732446 21.284286708045737 0.04461243649582885 0.09639231370167958 4.903629447437761e-06 5.309482355580453 -0.2834164213967838 VTKNEEPS(ph)EEEIDAPKPK ddPTM_A459_Selumetinib_30min_R1 2 VTKNEEPSEEEIDAPKPK 18 2 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 VT(0.023)KNEEPS(0.977)EEEIDAPKPK;VTKNEEPS(1)EEEIDAPKPK 122.47 0.0010274 465620000.0 6411.5 9868.1 18443.1 20614.3 10707.9 12513.4 9556.1 8847.0 5194.9 6557.1 True False 6560.875475392717 8712.73826444477 15938.628320696656 17014.399483336158 9739.37233563329 12387.526557258148 8835.275683339756 8612.34882089396 8815.365879515912 7398.767656562724 0.8867524674292488 1.177593170764938 2.154227441722549 2.2996261368262245 1.3163506123880568 1.6742688961546701 1.1941550395224056 1.164024770159499 1.1914640773584317 1.0 12.85306927921163 -7.311718354751463 5.132362646117284 1.1440698541131813 1.612851517650522 0.22958553007944615 0.39977771254788175 0.36007726623994296 21.80327881991803 0.18752012108168326 0.12646659342003777 4.8784476079468547e-08 7.311718354751463 0.46878166353734074 VTKNEEPS(ph)EEEIDAPKPK ddPTM_A459_Selumetinib_30min_R2 1 VTKNEEPSEEEIDAPKPK 18 2 Q9NR30;Q9NR30-2 Q9NR30 DDX21 Nucleolar RNA helicase 2 1 VTKNEEPS(1)EEEIDAPKPK 138.04 0.00038211 15724000.0 60466.0 61276.0 56557.0 55821.0 47388.0 31545.0 30173.0 30977.0 18860.0 56836.0 True False 57105.54178457625 65975.67216660571 52918.18419460566 48218.08350340398 41434.69578590491 35890.03741300094 31576.104286665246 31067.137941481604 22632.526992429255 55194.99700233745 1.0346144557659436 1.1953197889260092 0.9587496524796375 0.8735951829359099 0.7506965854921632 0.6502407711242567 0.5720827249130574 0.5628614843509447 0.41004671114432334 1.0 15.75224988338213 -6.0433770765625985 1.0789441521666978 0.6007621181173985 1.1240488364114292 0.6104233305224472 0.14862837163465573 0.3159137747645366 0.7521500687136696 0.05775580176193445 0.11239328338707211 9.049465390765233e-07 6.0433770765625985 0.5232867182940306 VTKS(ph)PAPVHR ddPTM_A459_Selumetinib_30min_R2 1 VTKSPAPVHR 10 1 Q9NRA8;Q9NRA8-3;B1AKL4;Q9NRA8-2;B0QYZ7 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 1 VT(0.004)KS(0.996)PAPVHR 81.565 0.024629 49125000.0 144410.0 113330.0 121450.0 151910.0 148720.0 106570.0 99888.0 105020.0 100000.0 128820.0 True False 136384.27031903292 122022.0465866153 113636.0392247621 131219.59594063347 130036.46402633097 121249.05015385992 104532.9899243169 105325.59081300304 120002.79423345295 125100.63188544422 1.0901964943224365 0.9753911291059824 0.9083570363483028 1.0489123353173184 1.039454893764298 0.9692121320769088 0.8355912224331425 0.8419269289498924 0.9592501046944398 1.0 16.932729551036424 -7.043134990946215 6.8027678780130865 0.896407992710038 1.0065404803510443 0.35337337016002435 0.06468699161383805 0.24360168182566416 30.5880647522075 0.024905512725532323 0.019579720068501914 9.054511174668755e-08 7.043134990946215 0.11013248764100625 VTLELGGK ddPTM_A459_Selumetinib_30min_R2 1 VTLELGGK 8 0 P00352;H0Y2X5;H0YMG7;O94788-4;P05091-2;O94788-2;O94788-3;P47895;P30837;P05091;O94788 P00352 ALDH1A1;ALDH1A3;ALDH1A2;ALDH2;ALDH1B1 Retinal dehydrogenase 1;Retinal dehydrogenase 2;Aldehyde dehydrogenase, mitochondrial;Aldehyde dehydrogenase family 1 member A3;Aldehyde dehydrogenase X, mitochondrial 0 132.08 0.047149 33765000.0 229820.0 206300.0 265740.0 277130.0 272650.0 210220.0 218510.0 210170.0 172450.0 256250.0 False True 217047.52444235308 222122.54664094863 248642.5777158353 239384.41592408446 238397.26947807422 239175.89681284057 228671.14796935066 210781.55990448353 206944.81865558965 248851.39668254182 0.8721973327689989 0.8925911190456728 0.999160868817735 0.9619572930485324 0.9579904820956104 0.9611193668241925 0.9189064277628508 0.8470177893892886 0.8315999886453838 1.0 17.924924958624025 -7.553443754759568 6.971309537587988 0.8797322805130593 0.9428352025139968 0.12179577077934511 0.05428737327730437 0.2977864774588616 47.62499119620557 0.025701855233834402 0.014917778416832093 2.7961228284682954e-08 7.553443754759568 0.06310292200093748 VTLLEGDHVR ddPTM_A459_Selumetinib_30min_R1 1 VTLLEGDHVR 10 0 O75534;O75534-4;O75534-2;O75534-3;E9PLT0 O75534 CSDE1 Cold shock domain-containing protein E1 0 107.45 0.014151 0.0 1300.7 1539.5 1176.7 1858.2 1611.8 1255.1 1285.4 1120.2 855.34 1167.5 False True 1331.003779278376 1359.2546243058673 1016.9106031504331 1533.7002527340362 1466.0129745864026 1242.4748335396202 1188.4412431185233 1090.488657077588 1451.44950843811 1317.3599974130314 1.0103569122275897 1.0318019576843889 0.7719306834482552 1.1642225782973854 1.1128415751694973 0.9431551253867834 0.9021385539657554 0.827783338813261 1.1017865361696098 1.0 10.363433932087894 -6.942256054201025 24.997170323497954 0.940584278408844 1.0148707940280586 0.06199386209225377 0.11616784749170554 219.01824048017522 94811.01441473178 0.041898662051312374 0.036951142529595075 1.1422047076541051e-07 6.942256054201025 0.07428651561921462 VTLLEGDHVR ddPTM_A459_Selumetinib_30min_R2 2 VTLLEGDHVR 10 0 O75534;O75534-4;O75534-2;O75534-3;E9PLT0 O75534 CSDE1 Cold shock domain-containing protein E1 0 ; 147.74 0.0027853 0.0 23842.0 19482.5 25045.0 25820.0 26254.0 22073.0 20568.9 21190.0 21591.7 22923.0 False True 22516.957087088056 20976.74510388889 23433.63196693422 22303.271458015613 22955.737806262056 25113.355391255973 21525.394606502126 21251.65939180665 25910.643322504486 22261.153428893333 1.0114910334278866 0.9423027055131216 1.0526692627040204 1.0018919967133246 1.031201634703582 1.1281246262226778 0.9669487556095703 0.9546522133135997 1.1639398383048016 1.0 14.44224072528564 -5.27200951124265 24.69282128440005 1.0350394367762477 0.976896867540273 0.12313165268891535 0.0643616200909428 1139.0818771571671 2661006.99238137 0.016552234393272813 0.03503160523112138 5.34552652327526e-06 5.27200951124265 -0.058142569235974606 VTLSFPS(ph)T(ph)LQTGT(ph)GT(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 VTLSFPSTLQTGTGTLK 17 0 E9PJY4;E9PPD4;E9PP11;E9PLK3;P55786-2;P55786;A6NEC2-3;A6NEC2 E9PJY4 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 4 VT(0.052)LS(0.062)FPS(0.943)T(0.943)LQT(0.207)GT(0.793)GT(1)LK 67.095 0.017106 18021000.0 10615.0 16694.0 33096.0 17359.0 30292.0 59763.0 24842.0 20070.0 29294.0 17124.0 True False 10025.060795211797 17974.376120329584 30966.639392200243 14994.674254054726 26486.44814608404 67994.81077550087 25997.202223489145 20128.400377232625 35153.618542747754 16629.58562650479 0.6028448946577188 1.0808673483530113 1.8621413718718627 0.9016865838289867 1.5927304949721086 4.088785631984026 1.563310283694257 1.210396989396495 2.113920294364926 1.0 14.021464599766052 -4.964173786331946 0.8717017651857646 1.9341984674182795 0.12916286335063756 0.17774204879761923 0.8502285590489889 3.282767445235655 2.343596975818987 0.3307337493897018 5.379375840540507 1.0859909688818999e-05 4.964173786331946 -1.8050356040676419 VTLT(ph)PDSK ddPTM_A459_Selumetinib_30min_R2 2 VTLTPDSK 8 0 C9J5X9;Q8NB91 C9J5X9 FANCB Fanconi anemia group B protein 1 VTLT(0.999)PDSK;VT(0.002)LT(0.998)PDSK 107.45 0.020456 0.0 118271.0 111411.0 125059.0 128082.0 129497.0 113491.0 131448.0 126206.0 106498.0 118756.0 True False 111697.97129632556 119955.86545717278 117012.84009394396 110637.01064622586 113228.42914213156 129123.3550812774 137560.59245927067 126573.23856547209 127800.57580274306 115327.20571485648 0.9685309776124802 1.0401350202983375 1.0146161035346262 0.9593314080614508 0.9818015483882087 1.1196261478885698 1.192785272187949 1.0975141362431093 1.1081563540065877 1.0 16.81537335967328 -6.7639559872964545 24.99937625399632 1.1152840894852525 0.9948515302751557 0.5526389400693107 0.04924253611150301 46.846000417524394 465353.2978875567 0.01674078315877435 0.015449298388845244 1.7220430831469813e-07 6.7639559872964545 -0.12043255921009677 VTLTSEEEAR ddPTM_A459_Selumetinib_30min_R1 3 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 ;; 220.39 0.0029862 78696000.0 5274.2 6104.799999999999 6342.9 7528.799999999999 6507.700000000001 5860.4 5956.3 6457.8 3692.14 4907.8 False True 5397.07859819329 5390.047177955474 5481.569019055733 6214.0364130793305 5919.079684027752 5801.44969681746 5507.011495555356 6286.5181661093075 6265.291916763726 5537.763936020275 0.9745952807934084 0.9733255588769358 0.989852417399192 1.1221201345655518 1.0688573497196614 1.0476159265442946 0.9944467765653769 1.135208766343176 1.1313757663108859 1.0 12.435087840426942 -5.645485261202371 6.819430561846454 1.0725187277633816 0.9760737036434939 0.4502826529352909 0.04678764007519107 0.20018551630843817 11.113950431589519 0.013216054223592712 0.023013860939212902 2.262115308633591e-06 5.645485261202371 -0.09644502411988776 VTLTSEEEAR ddPTM_A459_Selumetinib_30min_R2 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 132.88 0.032774 11141000.0 27912.0 31082.0 26918.0 39304.0 41447.0 26867.0 26401.0 32352.0 27247.0 29249.0 False True 26360.762780588946 33465.88945561783 25186.125186102418 33950.72739681822 36240.057319118765 30567.685375656907 27628.69881258904 32446.138963838086 32697.161344788947 28404.505371971423 0.9280486470502256 1.178189481470105 0.8866947287508554 1.1952585321313012 1.275855954699327 1.0761562285756272 0.972687200526015 1.142288469344543 1.1511258836090619 1.0 14.793832160064097 -4.744024597356532 24.74335460035299 1.099490948462093 0.9280480555698963 0.1738497722921225 0.11080238762444747 1800.6665229679074 2558276.959879968 0.028004148693120696 0.819934220935218 1.8029156253224043e-05 4.744024597356532 -0.1714428928921966 VTLYNTDQDGSDS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 VTLYNTDQDGSDSPR 15 0 C9JXI1;C9JVP0;Q9UPW0-2;Q9UPW0 C9JXI1 FOXJ3 Forkhead box protein J3 1 VTLYNTDQDGS(0.211)DS(0.789)PR;VTLYNTDQDGSDS(1)PR 247.44 7.0793e-28 29037000.0 3923.8 4216.4 4195.6 4336.3 4219.0 3816.64 3958.3 3661.2000000000003 2456.62 2945.9700000000003 True False 4015.21690561428 3722.7419278488173 3625.86056478113 3579.046607432247 3837.3921949249484 3778.248066831853 3659.722244154389 3564.093082746352 4168.704715574193 3324.113945677829 1.2079059175558815 1.119920071539456 1.0907750528514963 1.076691914272642 1.154410545978578 1.1366180969050446 1.100961731144305 1.0721934148438428 1.2540799694891749 1.0 11.698754121056385 -11.010506496264734 3.4671677658432336 0.9978495128214009 1.1291835578923073 0.3425859771523464 0.055541644762304436 19897024.84658044 875.2444614668253 343294.5342093209 0.013061897349561574 9.760981816469116e-12 11.010506496264734 0.1313340450709064 VTLYNTDQDGSDS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VTLYNTDQDGSDSPR 15 0 C9JXI1;C9JVP0;Q9UPW0-2;Q9UPW0 C9JXI1 FOXJ3 Forkhead box protein J3 1 VT(0.005)LYNT(0.006)DQDGS(0.37)DS(0.619)PR 90.872 0.015118 14579000.0 67892.0 73110.0 80371.0 82859.0 76368.0 87156.0 61944.0 65019.0 66625.0 81867.0 True False 64118.834433209486 78717.30191429835 75200.01736132827 71573.46126025254 66773.96910141772 99160.94787660512 64824.51873970739 65208.194525525105 79951.86165803812 79503.28699398885 0.8064928741632712 0.9901138039770617 0.9458730601542809 0.9002578882765455 0.8398894137102335 1.2472559516199948 0.8153690393280053 0.8201949503101101 1.0056422153222822 1.0 16.278726888146394 -4.749672583881837 24.39766903269856 0.9457071626760204 0.806492447796805 0.11360469208986168 0.1206018060367276 963.8234030607149 1998252.1965442235 0.029802810697807058 0.4620596093612867 1.7796205665496674e-05 4.749672583881837 -0.13921471487921544 VTMILQS(ph)PSFR ddPTM_A459_Selumetinib_30min_R2 1 VTMILQSPSFR 11 0 P35612;A0A1C7CYY0;P35612-5;P35612-6;P35612-4;P35612-3;C9J299;C9J080;C9JTM0;P35612-7;P35612-2;P35612-8;P35612-9 P35612 ADD2 Beta-adducin 1 VT(0.006)MILQS(0.992)PS(0.002)FR 98.0 0.018683 2095100.0 17404.0 11695.0 12329.0 13494.0 12846.0 11855.0 12350.0 11301.0 10529.0 8854.5 True False 16436.755353732085 12591.96889464804 11535.765562800241 11656.093921551614 11232.170635302908 13487.91864102477 12924.299471060747 11333.88403901873 12635.094204840267 8598.847578246134 1.911506769269262 1.4643786600548587 1.3415478595043473 1.355541404296999 1.3062413925929688 1.5685728254036382 1.5030269293012466 1.3180701176390022 1.4693939030626924 1.0 13.069927606737856 -13.398454198445895 0.12403100219689576 6.592413850568847e-32 1.668033650562726 0.4664741387128851 0.16083521077808627 113.61896712887264 1.1854081444895386 31.48523041528492 1.5819586477278151 3.9952669396104695e-14 13.398454198445895 1.668033650562726 VTNDIS(ph)PESS(ph)PGVGR ddPTM_A459_Selumetinib_30min_R2 2 VTNDISPESSPGVGR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 2 VTNDIS(0.996)PES(0.021)S(0.983)PGVGR;VTNDIS(0.991)PES(0.033)S(0.976)PGVGR 163.9 0.0018063 49914000.0 93363.0 81824.0 103070.0 111006.0 106662.0 72917.0 76455.0 82162.0 67122.0 80283.0 True False 88174.25822170128 88099.63769437208 96438.58841413082 95886.7913039691 93262.1659896216 82960.65487537767 80010.30899270833 82401.07781734876 80548.2755453783 77965.0211897153 1.1309463766724752 1.1299892740360555 1.2369468633820166 1.2298693675801622 1.1962052285304092 1.064075320052903 1.026233402771945 1.0568980365802638 1.0331335041823058 1.0 16.250539387182542 -6.8305487632519375 4.365440246297937 1.0355226760144485 1.1874564061665518 0.8133721681868578 0.03580849898579043 0.10086011224338014 3.724389764270252 0.01430536703723632 0.012780255387927146 1.4772406054316804e-07 6.8305487632519375 0.15193373015210332 VTNDISPES(ph)SPGVGR ddPTM_A459_Selumetinib_30min_R1 2 VTNDISPESSPGVGR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 VT(0.001)NDIS(0.022)PES(0.896)S(0.081)PGVGR;VT(0.023)NDIS(0.071)PES(0.855)S(0.052)PGVGR 170.47 5.2361e-05 140360400.0 10454.6 11041.9 11969.3 11946.400000000001 11591.5 9760.7 11115.800000000001 10825.9 5381.0 8726.0 True False 10698.171838889602 9749.109214759957 10343.934802658681 9860.185501701588 10543.050871645544 9662.516220006519 10277.326256618075 10538.761964520842 9131.163987309685 9846.067098437774 1.0865426501701403 0.990152628180525 1.050565134204692 1.0014339129647059 1.0707880381313222 0.9813579496669916 1.04380014414575 1.070352442163732 0.9273920130768234 1.0 13.265331855867368 -8.261412675082832 24.999999999992212 0.9636960069505379 1.0341025501585241 0.3747682586772191 0.037671866194009224 2.3872411905798914 2240485.662680398 0.027235105193122954 0.008798813268250131 5.477562289066237e-09 8.261412675082832 0.07040654320798623 VTNDISPES(ph)SPGVGR ddPTM_A459_Selumetinib_30min_R2 3 VTNDISPESSPGVGR 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 VT(0.053)NDIS(0.021)PES(0.849)S(0.077)PGVGR;VT(0.039)NDIS(0.02)PES(0.931)S(0.01)PGVGR;VTNDIS(0.205)PES(0.702)S(0.094)PGVGR 179.66 2.002e-05 659118000.0 204932.0 218414.0 237077.0 236750.0 246121.0 160917.0 160179.0 195436.0 183390.0 216949.0 True False 193542.6998477948 235165.651488299 221823.7239299208 204504.24158346985 215201.07963034287 183081.85609091396 167627.64088866717 196004.68640382838 220073.12434472915 210685.11866880383 0.9186348854189516 1.1161948835027995 1.052868495561031 0.9706629631727797 1.0214346461205839 0.8689833304207779 0.7956311387714913 0.9303205069359786 1.0445594151843407 1.0 17.6847288902488 -6.744693337401965 24.115135588921362 0.9152771861152367 1.0210619403780212 0.22476408904861334 0.07979341299112866 216.0103642768533 311064.52216733375 0.02730894972485406 0.027228449833610224 1.8001415765361814e-07 6.744693337401965 0.10578475426278455 VTNGAFTGEIS(ph)PGMIK ddPTM_A459_Selumetinib_30min_R1 2 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 1 VTNGAFT(0.248)GEIS(0.752)PGMIK;VTNGAFT(0.008)GEIS(0.992)PGMIK 146.67 0.00033974 64473000.0 7261.3 7747.1 8979.8 8593.0 7539.0 7144.5 8171.5 7862.0 4246.5 6398.7 True False 7430.474161969764 6840.0659304709225 7760.392482510629 7092.393860587435 6857.098781118553 7072.632816686978 7555.117176087607 7653.474220624878 7206.000347911278 7220.035473616068 1.029146489532177 0.947372898023333 1.0748413232690017 0.9823211930889993 0.9497320070207713 0.9795842198466007 1.046409980075031 1.0600327724971312 0.9980560863231105 1.0 12.817790210068752 -7.259616265736623 24.819574184868493 1.0311274408446638 0.9928755368766429 0.13479463194557506 0.03922446521290034 269.50411613083344 3668979.744740743 0.015574039116832012 0.011467310069691145 5.500266522001726e-08 7.259616265736623 -0.03825190396802092 VTNGAFTGEIS(ph)PGMIK ddPTM_A459_Selumetinib_30min_R2 1 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 1 VTNGAFT(0.022)GEIS(0.978)PGMIK 102.84 0.0047247 11390000.0 65469.0 48338.0 69887.0 62043.0 58620.0 40291.0 47660.0 49505.0 46238.0 54340.0 True False 61830.49507317205 52045.36916883257 65390.54650721221 53592.636369855296 51255.631530550876 45840.71952471774 49876.2844364984 49649.05135400608 55486.891997663995 52771.06300772431 1.171674238666022 0.9862482618781904 1.2391364278115968 1.015568633931265 0.9712829078892798 0.8686715201853684 0.9451445848115245 0.9408385680375388 1.0514643601085345 1.0 15.68745942467847 -5.989482515467822 24.256458973165543 0.957895990536219 1.11934424299183 0.5129117426921164 0.07343343465593706 121.18572330353946 279486.24882736366 0.020179499229728462 0.029892055787459737 1.0245130259884479e-06 5.989482515467822 0.16144825245561112 VTNVLIT(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 VTNVLITPGK 10 0 Q96HE9 Q96HE9 PRR11 Proline-rich protein 11 1 VTNVLIT(1)PGK 102.52 0.035551 4131900.0 73172.0 56467.0 59882.0 74996.0 63657.0 56583.0 76658.0 71630.0 59993.0 55758.0 True False 69105.39317072427 60797.83732997787 56029.257314591916 64781.415424683895 55659.838559199554 64376.79464066678 80222.74889494525 71838.43144101505 71993.27634447544 54148.121663317856 1.276228815477806 1.122806026550775 1.0347405522756743 1.1963741942422625 1.0279181779431104 1.188901713727925 1.4815425989059083 1.3267021871541915 1.3295618413527837 1.0 15.724623672802867 -7.012820788278797 24.247942105796735 1.3150404748868207 1.127247185573857 0.21806826974730997 0.13142977058795885 489.46566794087187 925725.0904243343 0.04615779685613839 0.03758537922428333 9.709105310548853e-08 7.012820788278797 -0.18779328931296368 VTPDIEES(ph)LLEPENEK ddPTM_A459_Selumetinib_30min_R1 1 VTPDIEESLLEPENEK 16 0 Q14151 Q14151 SAFB2 Scaffold attachment factor B2 1 VTPDIEES(1)LLEPENEK 142.74 0.00039359 3358700.0 2070.6 2341.0 1940.2 2133.1 1522.8 2079.2 2302.4 2283.9 1210.9 1549.1 True False 2118.840951313759 2066.9146316986253 1676.731496755732 1760.594128246138 1385.0630088721766 2058.285135762553 2128.7281143271266 2223.3235528472605 2054.808859363185 1747.942074511799 1.2121917437713443 1.1824846268294762 0.9592603331686742 1.0072382568729417 0.7923964009270875 1.177547680656084 1.2178482029627218 1.271966379931804 1.175558898275902 1.0 10.771441660462122 -6.9572895108337605 24.999930753269837 1.190249701136812 1.0289819813212535 0.21829739835662298 0.12739135578515864 199.4702648571921 116756.28650736419 0.04708465145011616 0.04152472753368417 1.1033428606002118e-07 6.9572895108337605 -0.16126771981555854 VTPDTDWAR ddPTM_A459_Selumetinib_30min_R1 1 VTPDTDWAR 9 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 140.35 0.031865 10069000.0 1342.0 1968.6 1989.9 1936.6 1864.6 1673.4 1822.1 1752.2 765.8 1555.7 False True 1373.265988922565 1738.1153968226884 1719.6825097382912 1598.4091644843036 1695.947259221867 1656.5671153256335 1684.6575300188745 1705.7259640522673 1299.5066681809617 1755.3892488012445 0.7823142302257852 0.9901595318586163 0.979658791298091 0.9105724930102297 0.9661374309886137 0.9437035782558787 0.959705963318009 0.9717081070293142 0.7402954467611073 1.0 10.777575261088362 -10.59646904973524 4.675813173767122 1.0000025434490467 0.9251297827746832 0.07675567202786293 0.08207671727694242 111541269.42364782 0.5348221210342378 4188.813987469107 0.019021294313741804 2.532392101339017e-11 10.59646904973524 -0.07487276067436355 VTPFNYNPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 VTPFNYNPSPR 11 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 1 VTPFNYNPS(1)PR;VTPFNYNPS(1)PR 88.78 0.030163 10450800.0 22616.5 24469.0 20591.5 25814.0 24814.0 21167.9 18531.1 19684.7 16008.9 23554.0 True False 21359.565471022866 26345.693619764243 19266.66530833004 22298.088668366203 21696.64348002541 24083.586081935755 19392.832868678022 19741.97921802248 19211.127326039274 22873.934819358452 0.9337949784199805 1.151777944102018 0.8422978145423611 0.9748252255005595 0.9485313152883217 1.0528833920412137 0.8478135931499492 0.8630775323061004 0.839869811545528 1.0 14.481416941892164 -7.2757750938396955 24.655762348960764 0.8762800230066746 0.9831711069442156 0.22603114297895 0.08628899732367992 937.0406793686011 1611594.0884355297 0.034854164613673466 0.023620560123601957 5.299378093901085e-08 7.2757750938396955 0.10689108393754099 VTPLPSLAS(ph)PAVPAPGYCSR ddPTM_A459_Selumetinib_30min_R1 1 VTPLPSLASPAVPAPGYCSR 20 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3;H7C3V8 C9JWC4 HJURP Holliday junction recognition protein 1 VT(0.001)PLPS(0.393)LAS(0.602)PAVPAPGY(0.001)CS(0.003)R 147.84 2.0506e-05 19394000.0 1437.3 1485.4 2208.0 2104.2 1667.1 1247.0 1530.0 1570.9 1007.1 981.87 True False 1470.7862935010462 1311.488677456274 1908.1657276758342 1736.7409707259492 1516.3110993504104 1234.45631218541 1414.5908681899336 1529.2346289976622 1708.975144326256 1107.9025787237113 1.3275411771271188 1.1837581233605314 1.7223226701701653 1.5675935809506385 1.3686321599658882 1.1142282145488704 1.27681882446697 1.3802970210244656 1.54253196729172 1.0 10.113615311020796 -6.5233025885951905 24.99892001618819 1.2823113445640903 1.4528720848477459 0.17590460636780747 0.18952376294878576 30.8323043999778 1818346.1376110292 0.06511062068498666 0.06570761291236712 2.9970736223142723e-07 6.5233025885951905 0.17056074028365553 VTPLPSLAS(ph)PAVPAPGYCSR ddPTM_A459_Selumetinib_30min_R2 2 VTPLPSLASPAVPAPGYCSR 20 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3;H7C3V8 C9JWC4 HJURP Holliday junction recognition protein 1 VT(0.006)PLPS(0.001)LAS(0.993)PAVPAPGYCSR;VTPLPSLAS(1)PAVPAPGYCSR 145.17 2.7311e-05 21417000.0 48773.0 47070.0 56990.0 62629.0 51297.0 45513.0 50706.0 45989.0 48467.0 57697.0 True False 46062.39191378854 50680.11764609518 53323.32544602042 54098.82215894888 44852.61225900147 51782.00262412146 53063.92947203285 46122.82037611118 58161.75428112772 56031.13769519077 0.8220856082624597 0.904499171903217 0.9516730810660878 0.9655135409394383 0.800494405503589 0.9241647547086301 0.9470435842423988 0.8231640882792562 1.0380255813745474 1.0 15.773941165898494 -8.27845715741107 24.67806598977506 1.0190128275724246 0.8969767736546469 0.442908233624821 0.05663943724838423 756.4091942648578 1096882.708912605 0.05360820680692285 0.013992958429771059 5.266751681554389e-09 8.27845715741107 -0.12203605391777772 VTPLPSLASPAVPAPGYCS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 VTPLPSLASPAVPAPGYCSR 20 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3;H7C3V8 C9JWC4 HJURP Holliday junction recognition protein 1 VTPLPSLAS(0.013)PAVPAPGYCS(0.987)R 191.47 1.5250999999999999e-15 13549000.0 824.36 629.64 811.42 601.02 539.72 632.77 706.82 678.62 315.8 424.33 True False 843.5659840746695 555.9214560883053 701.2336208110178 496.06313954268137 490.90242129530515 626.4049083091912 653.5039983359536 660.6207931315772 535.8895348805794 478.79688882421505 1.7618451660081178 1.1610799256726283 1.464574305261344 1.0360617437612578 1.0252832312691458 1.3082894290467473 1.364887729201349 1.3797516411476032 1.1192418902231531 1.0 8.903269967594028 VTPRPQQTSAS(ph)SPSSVNSR ddPTM_A459_Selumetinib_30min_R2 1 VTPRPQQTSASSPSSVNSR 19 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTPRPQQT(0.004)S(0.004)AS(0.464)S(0.359)PS(0.129)S(0.033)VNS(0.006)R 68.676 0.010339 32220000.0 10336.0 9399.4 12483.0 13851.0 11733.0 12169.0 10717.0 7963.3 8217.1 9309.8 True False 9761.566498286304 10120.303756165433 11679.857370462758 11964.469905692276 10258.995645649156 13845.169290816566 11215.361735332628 7986.471884604721 9860.749604957071 9041.001884234664 1.0796996420615874 1.1193785695159308 1.291876444670322 1.323356643311339 1.1347188925530898 1.5313755563926181 1.2404998781041652 0.8833613781821249 1.0906700088351768 1.0 13.14226693930772 -7.743236385907356 23.32464979750691 0.9902619034946432 1.2524395118536693 0.4475185555800768 0.12943691775630395 97.0039345606825 124297.78123236731 0.06299280515456299 0.036249672776133376 1.8061907511931348e-08 7.743236385907356 0.26217760835902615 VTPRPQQTSASS(ph)PSSVNSR ddPTM_A459_Selumetinib_30min_R1 3 VTPRPQQTSASSPSSVNSR 19 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTPRPQQTS(0.003)AS(0.224)S(0.632)PS(0.08)S(0.056)VNS(0.005)R;VTPRPQQT(0.001)S(0.016)AS(0.139)S(0.832)PS(0.01)S(0.001)VNSR;VTPRPQQTSAS(0.073)S(0.678)PS(0.246)S(0.003)VNSR 230.48 5.3368e-23 52337400.0 2096.48 2594.59 2949.0599999999995 3023.1800000000003 2209.92 2282.73 2549.5299999999997 2366.3 1534.54 2351.37 True False 2145.3239049600456 2290.8141966078324 2548.5938500270386 2495.2383651170394 2010.0331261930664 2259.767808753008 2357.2168994616204 2303.5380371743395 2604.002301632821 2653.1912437833635 0.8085824608334242 0.8634184218628759 0.9605767605326586 0.9404668325223746 0.7575907431862414 0.8517168952851862 0.8884459064097869 0.8682140959765757 0.9814604611462532 1.0 11.373512954391478 -8.29837967600515 4.12365390071428 0.9980830217428353 0.8688762942499626 0.44611091632589595 0.05507422413600718 0.2193296423077991 8.028589094876068 0.05398538950166618 0.01501423780285602 5.030606226277459e-09 8.29837967600515 -0.12920672749287265 VTPRPQQTSASS(ph)PSSVNSR ddPTM_A459_Selumetinib_30min_R2 2 VTPRPQQTSASSPSSVNSR 19 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTPRPQQTS(0.001)AS(0.195)S(0.789)PS(0.011)S(0.004)VNSR;VTPRPQQTS(0.001)AS(0.023)S(0.906)PS(0.044)S(0.014)VNS(0.012)R 98.135 0.00081459 58928000.0 14156.3 9004.2 11866.1 10802.7 15123.0 9871.0 11196.5 9517.7 10377.7 11469.9 True False 13369.549518158898 9694.793186933719 11102.648044832828 9331.353624303074 13223.113538664635 11230.640649983592 11717.159435443851 9545.394931259942 12453.529977165063 11138.734184620846 1.2002754798312827 0.8703675863204668 0.9967603015576185 0.837739142494916 1.1871289250192965 1.0082510690927198 1.0519291726722084 0.8569550878087374 1.1180381693962627 1.0 13.443297672431083 -4.738287542312914 24.762264901000734 0.9912585124141464 1.200276459772115 0.25403088879621194 0.10711437754596914 2535.6540100060092 2711874.903305855 0.02565284902471957 1.4473698984990564 1.826890248692845e-05 4.738287542312914 0.20901794735796853 VTPRPQQTSASSPS(ph)SVNSR ddPTM_A459_Selumetinib_30min_R1 1 VTPRPQQTSASSPSSVNSR 19 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTPRPQQTS(0.001)AS(0.142)S(0.1)PS(0.538)S(0.199)VNS(0.02)R 83.359 0.0025234000000000003 33282000.0 652.45 924.68 854.94 1055.7 1030.1 645.54 936.38 795.75 350.76 739.71 True False 667.6508155532994 816.4180357279309 738.8438438492658 871.3418129433438 936.9276368789259 639.0464537034233 865.7481027161365 774.6441250397166 595.2141015032049 834.6589838855615 0.7999084996907428 0.9781456277236554 0.8852044465031089 1.0439494808850123 1.122527469263287 0.7656377826648323 1.0372476896921983 0.9280965519996447 0.713122500320219 1.0 9.705043066705217 -8.022025046774145 24.588865095225344 0.8445773207167792 0.9520954362974096 0.07691199094023915 0.1221687627543497 1387.5781965750682 1549087.7666452792 0.07780147991685175 0.03000384180915442 9.5054997164496e-09 8.022025046774145 0.1075181155806304 VTPRPQQTSASSPSS(ph)VNSR ddPTM_A459_Selumetinib_30min_R1 1 VTPRPQQTSASSPSSVNSR 19 1 Q9ULD2;Q9ULD2-5;H0YC63;Q9ULD2-2 Q9ULD2;Q9ULD2-2 MTUS1 Microtubule-associated tumor suppressor 1 1 VTPRPQQT(0.058)S(0.058)AS(0.195)S(0.195)PS(0.198)S(0.247)VNS(0.05)R 50.539 0.046638 2320300.0 266.38 321.41 339.25 442.39 187.05 261.27 450.6 193.03 178.25 170.26 True False 272.58613571474876 283.779167780545 293.1817133668602 365.1348911887906 170.13136052635974 258.64186101417965 416.610879219859 187.91021735019348 302.4772311350962 192.1145294728417 1.4188730881663114 1.4771353762738777 1.5260777733539717 1.900610496200955 0.885572585234426 1.3462899538306008 2.168554769714871 0.9781155952431877 1.5744630661985195 1.0 7.585822822811172 -9.589273312809864 0.7229580262232987 0.9812578361424253 1.4870405241056768 0.1336540813220184 0.35950562854182583 12.315315677654594 6.528742716562689 1.031378919860642 0.12697468005724089 2.5747003211802596e-10 9.589273312809864 0.5057826879632514 VTPTEEHVEGPLPS(ph)PVTNGTSPAQLNGGSACSSR ddPTM_A459_Selumetinib_30min_R2 2 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSR 34 0 H3BN50;Q15599-3;H3BUQ9;H3BQS0;Q15599;Q15599-2 H3BN50;Q15599-2 SLC9A3R2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 1 VTPTEEHVEGPLPS(0.439)PVT(0.439)NGT(0.104)S(0.016)PAQLNGGS(0.002)ACSSR;VTPTEEHVEGPLPS(0.996)PVT(0.004)NGTSPAQLNGGSACSSR 114.13 2.381e-15 21312000.0 17426.6 14207.2 19983.9 21202.6 18239.699999999997 14926.9 16473.7 15036.7 14628.5 13765.3 True False 16458.09933620705 15296.846556651868 18698.157630825182 18314.769303474906 15948.265821013105 16982.94498209301 17239.759692017276 15080.454307540302 17554.608754440687 13367.860022455417 1.2311693351486797 1.1443003241323688 1.3987397832873696 1.370059925276719 1.1930305818749676 1.2704310902092744 1.2896424456164126 1.1281128230104187 1.3131951355678726 1.0 13.706480911391028 -11.59114234313037 0.35921414535961654 0.7130932101240103 1.271923681234548 0.4567830369405844 0.084693708514566 39.453902727509245 2.0961787303963866 9.346247640135593 0.06562737800205709 2.56364364621669e-12 11.59114234313037 0.5588304711105377 VTQGAAS(ph)PGHGIQEK ddPTM_A459_Selumetinib_30min_R2 2 VTQGAASPGHGIQEK 15 0 Q9HB58-7;G5E9C0;Q9HB58-2;Q9HB58-5;Q9HB58-3;Q9HB58;Q9HB58-6;Q9HB58-4 Q9HB58-7 SP110 Sp110 nuclear body protein 1 VTQGAAS(1)PGHGIQEK;VTQGAAS(1)PGHGIQEK 91.475 0.014497 8391000.0 40907.0 41369.0 47543.0 47351.0 46526.0 34330.0 32529.0 30886.0 30015.0 40368.0 True False 38633.55270369561 44541.86927769944 44484.13514090451 40901.71211496892 40680.987932282675 39058.645883288096 34041.66295499067 30975.873146547437 36018.83868917091 39202.47095133996 0.9854876941723771 1.1362005556483163 1.1347278388681268 1.0433452566226793 1.0377148925836315 0.9963312244212773 0.8683550329581231 0.7901510388209003 0.9187900103000974 1.0 15.258656970545433 -6.977227345386237 2.001955055116042 0.8766289924591425 1.0782817400056035 0.6042924867566317 0.06519102288925892 0.20321950327596097 1.6431965438973537 0.028579410401561957 0.022539703408230815 1.0538350881708229e-07 6.977227345386237 0.201652747546461 VTQHES(ph)DNENEIQIQNK ddPTM_A459_Selumetinib_30min_R1 3 VTQHESDNENEIQIQNK 17 0 Q5VZL5-2;Q5VZL5-4;Q5VZL5 Q5VZL5-2 ZMYM4 Zinc finger MYM-type protein 4 1 VT(0.106)QHES(0.894)DNENEIQIQNK;VTQHES(1)DNENEIQIQNK;VT(0.124)QHES(0.876)DNENEIQIQNK 239.55 1.5363999999999995e-22 38117600.0 8611.6 10314.900000000001 8796.4 9069.9 9624.7 8879.0 9564.3 8668.0 4670.719999999999 7870.6 True False 8812.233524743346 9107.226712733087 7601.897195166536 7486.012228109154 8754.147584378803 8789.68532148697 8842.857150737891 8438.096482367906 7925.870704108364 8880.86817613619 0.992271628175129 1.0254883342605114 0.855985816295936 0.8429369831459544 0.9857310581303416 0.989732664325067 0.9957198975770817 0.9501431971529476 0.8924657529999148 1.0 13.116485003149933 VTQHES(ph)DNENEIQIQNK ddPTM_A459_Selumetinib_30min_R2 6 VTQHESDNENEIQIQNK 17 0 Q5VZL5-2;Q5VZL5-4;Q5VZL5 Q5VZL5-2 ZMYM4 Zinc finger MYM-type protein 4 1 VT(0.009)QHES(0.991)DNENEIQIQNK;VT(0.03)QHES(0.97)DNENEIQIQNK;VT(0.145)QHES(0.855)DNENEIQIQNK;VT(0.008)QHES(0.992)DNENEIQIQNK;VTQHES(1)DNENEIQIQNK;VT(0.001)QHES(0.999)DNENEIQIQNK 203.89 2.2821e-08 127988300.0 411393.0 361080.0 444547.0 466595.0 487273.0 402879.0 407075.0 437647.0 347418.0 420189.0 True False 388529.4239966619 388773.67494480626 415945.33000617696 403043.95607872977 426057.4094641092 458371.9252785674 426004.79410381 438920.48031363916 416911.30766997754 408057.0517878674 0.9521448588974339 0.9527434294822926 1.0193313120891987 0.9877147185983598 1.044112355361523 1.1233035264805489 1.0439834141753122 1.0756350818851097 1.0216985733816288 1.0 18.63841134863668 -5.725026125028628 1.1615856111576544 1.0574922534541298 0.9498780630390281 0.5243646093336605 0.03479500766211806 0.41173631078170564 1.068684868012347 0.012569388634678502 0.03602393197053644 1.8835357817957349e-06 5.725026125028628 -0.10761419041510167 VTQVDGNS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 1 VTQVDGNSPVR 11 0 B0YIW6;P48444-2;P48444 B0YIW6 ARCN1 Coatomer subunit delta 1 VTQVDGNS(1)PVR 103.13 0.013591 5707300.0 2057.0 2225.5 1828.8 1824.7 1825.4 1818.4 2119.3 2202.8 1572.0 2210.2 True False 2104.9240977747518 1964.9374253931187 1580.4590048793332 1506.0503988611547 1660.292892300545 1800.1085469750988 1959.4394947417811 2144.3745882971866 2667.5691856626695 2493.9006991711176 0.8440288334152007 0.7878972190216686 0.6337297252471281 0.6038934907719908 0.6657413796998278 0.7218044197082064 0.7856926682738523 0.8598476230468596 1.0696372901091342 1.0 11.284188306499482 -7.917309384461186 1.7010725350982159 1.0370288436054784 0.7044493939002973 0.7590266882521812 0.07092343155762561 0.19770869527257717 1.049833513976803 0.0656270259296723 0.023013518348444024 1.209736029862119e-08 7.917309384461186 -0.33257944970518116 VTQVDGNS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 VTQVDGNSPVR 11 0 B0YIW6;P48444-2;P48444 B0YIW6 ARCN1 Coatomer subunit delta 1 VTQVDGNS(1)PVR 89.74700000000001 0.030544 0.0 16721.0 17833.0 23654.0 23424.0 25633.0 22999.0 30797.0 32288.0 23905.0 23108.0 True False 15791.713759466453 19200.73375786734 22132.127392527927 20233.610791346167 22412.753378072495 26166.903485864907 32229.121523097783 32381.952734433864 28686.66796150696 22440.811998205612 0.703705095908703 0.8556167111690365 0.9862444992764804 0.9016434339793081 0.9987496611024878 1.1660408495003316 1.4361833932602284 1.4429938068650614 1.2783257559397037 1.0 14.453837258909259 -6.749035816973561 1.9011922217516146 1.325699784163746 0.8691197254069124 0.6706969074253041 0.13468022468891946 0.18793926280372766 1.401367097086088 0.05440226504508837 0.050292712687408994 1.7822317778282544e-07 6.749035816973561 -0.4565800587568335 VTRS(ph)PPTQVAISSDSAR ddPTM_A459_Selumetinib_30min_R1 2 VTRSPPTQVAISSDSAR 17 1 Q6ZUT6;H0YM82;Q6ZUT6-3;Q6ZUT6-4 Q6ZUT6 C15orf52 Uncharacterized protein C15orf52 1 VT(0.288)RS(0.674)PPT(0.017)QVAIS(0.003)S(0.017)DSAR;VT(0.024)RS(0.921)PPT(0.03)QVAIS(0.003)S(0.023)DSAR 180.02 3.7607e-07 23543000.0 5241.200000000001 7233.1 9480.8 10007.6 8761.9 6672.700000000001 6578.0 6021.5 3460.8999999999996 4278.3 True False 5363.309762400112 6386.245289423037 8193.359434306642 8259.960525918166 7969.3876920390885 6605.578696326851 6081.81616402182 5861.790259411434 5872.894525865096 4827.461479171022 1.1110000122302595 1.322899274696997 1.697239733482786 1.7110360303354668 1.6508443881788575 1.3683337971370348 1.2598373265665495 1.2142593544667764 1.2165595833762297 1.0 12.237049031868947 -7.2492448256032525 2.1137488656573993 1.1681708371783062 1.5099081110557957 0.4188659992744699 0.18139599472105178 0.37061760005119987 3.2380258554142047 0.09939574329023856 0.06463549853592965 5.6332000490783414e-08 7.2492448256032525 0.34173727387748953 VTRS(ph)PPTQVAISSDSAR ddPTM_A459_Selumetinib_30min_R2 3 VTRSPPTQVAISSDSAR 17 1 Q6ZUT6;H0YM82;Q6ZUT6-3;Q6ZUT6-4 Q6ZUT6 C15orf52 Uncharacterized protein C15orf52 1 VT(0.005)RS(0.944)PPT(0.039)QVAIS(0.006)S(0.006)DSAR;VT(0.005)RS(0.995)PPTQVAISSDSAR;VT(0.433)RS(0.566)PPT(0.001)QVAISSDSAR 130.87 0.0039294 12096700.0 33262.2 33441.4 38426.7 37003.4 39024.3 25035.5 27496.8 29840.300000000003 24903.7 33227.4 True False 31413.620083136484 36006.247848951076 35954.36795782755 31963.473085574566 34121.71855233154 28483.91287535854 28775.455683875538 29927.130332672412 29885.13586751644 32268.038626846857 0.9735212123181388 1.115848665775243 1.114240886271708 0.9905613866155815 1.0574463154368 0.8827283617932717 0.8917633952481541 0.927454273832844 0.9261528478105933 1.0 14.977818267590653 -6.752788435076974 24.998931895250376 0.918969642764862 1.0541948233495066 0.590841011350077 0.05168933017356223 125.00790753916952 361239.2036943517 0.017199875678646878 0.016943037422322223 1.7668983489511417e-07 6.752788435076974 0.1352251805846446 VTS(ph)PTTYVLDEDEPR ddPTM_A459_Selumetinib_30min_R1 4 VTSPTTYVLDEDEPR 15 0 J3KNS1;Q9UPW5-2;Q9UPW5;Q9UPW5-3 J3KNS1 AGTPBP1 Cytosolic carboxypeptidase 1 1 VT(0.064)S(0.936)PTTYVLDEDEPR;VT(0.07)S(0.929)PT(0.001)TYVLDEDEPR;VT(0.005)S(0.994)PT(0.001)TYVLDEDEPR;VT(0.062)S(0.937)PT(0.001)TYVLDEDEPR 290.17 3.3950999999999985e-67 29375300.0 4882.8 5817.5 5918.299999999999 6249.6 5587.2 4675.75 5189.4 4811.429999999999 2626.66 3872.43 True False 4996.559739725116 5136.384395517623 5114.627366894882 5158.224679521382 5081.838746500277 4628.7162002413215 4797.9593799900895 4683.815246672749 4457.250176343961 4369.494111162433 1.1435098921316231 1.1755100853428477 1.1705307838335128 1.180508440632529 1.1630267983467624 1.0593254236037697 1.0980583238991184 1.0719353608252593 1.020083804428834 1.0 12.09325054251948 -7.393795356270299 0.6484794057258619 1.0047685986835095 1.1758783553653458 0.8574089656906305 0.024230657213579563 0.277898054842746 0.23195408902197712 0.02284698723210071 0.014576021111886247 4.038356393717714e-08 7.393795356270299 0.17110975668183626 VTS(ph)PTTYVLDEDEPR ddPTM_A459_Selumetinib_30min_R2 3 VTSPTTYVLDEDEPR 15 0 J3KNS1;Q9UPW5-2;Q9UPW5;Q9UPW5-3 J3KNS1 AGTPBP1 Cytosolic carboxypeptidase 1 1 VT(0.003)S(0.995)PT(0.002)TYVLDEDEPR;VT(0.06)S(0.94)PTTYVLDEDEPR;VT(0.003)S(0.997)PTTYVLDEDEPR 312.67 1.0386999999999995e-94 12726300.0 53044.0 44097.0 54979.0 58226.0 68569.0 43772.0 46599.0 48921.0 41440.0 48587.0 True False 50096.026831956144 47479.09810579691 51441.71099660913 50295.518354547574 59954.74920536241 49801.195677345946 48765.94583416674 49063.35201069245 49729.15793034295 47184.16706581337 1.0617126453049655 1.0062506357179553 1.0902324698210155 1.0659405788470193 1.2706539700433068 1.055464126512656 1.0335235072847015 1.0398265999325145 1.053937390925642 1.0 15.526015215246582 -10.397988461852327 6.286587046044646 0.9999999936141181 1.0763093429802575 0.09719695951457785 0.06876709271883136 6.554086254151836e-09 1.1674310224174901e-09 0.07036034783771883 0.017064889542018267 3.9995537546111516e-11 10.397988461852327 0.07630934936613942 VTSFSTPPT(ph)PER ddPTM_A459_Selumetinib_30min_R1 1 VTSFSTPPTPER 12 0 B0QY16;Q6ICG6-3;Q6ICG6;Q6ICG6-2 B0QY16 KIAA0930 Uncharacterized protein KIAA0930 1 VTSFSTPPT(1)PER 120.59 0.0093425 9067400.0 808.91 685.74 721.5 1087.5 896.16 831.85 808.49 911.92 396.33 905.74 True False 827.7560291351358 605.4532420081231 623.524262915813 897.5885399032741 815.1024862298983 823.4823442593689 747.504948380967 887.7329192663751 672.54306320209 1022.0005516547137 0.8099369690113396 0.592419682188858 0.6101016891881998 0.8782661990250347 0.7975558182529078 0.8057552835231592 0.731413449014961 0.8686227398107106 0.6580652643613356 1.0 9.99718025967471 -14.522878745279954 0.14613691580136184 1.831510645298956 0.67386058459674 0.3588519207562392 0.09768404222825368 153.21822755809174 1.3413426083577624 37.403417293440945 0.5426916816787237 3.0000000000026516e-15 14.522878745279954 -1.157650060702216 VTSGGVSES(ph)PSGFSK ddPTM_A459_Selumetinib_30min_R2 1 VTSGGVSESPSGFSK 15 0 E7EPP6;O14757-2;O14757-3;O14757 E7EPP6 CHEK1 Serine/threonine-protein kinase Chk1 1 VTSGGVS(0.105)ES(0.636)PS(0.258)GFS(0.001)K 79.337 0.031273 8197900.0 16527.0 12931.0 14661.0 14583.0 17538.0 14321.0 11862.0 12524.0 11016.0 16907.0 True False 15608.49550282293 13922.766120281649 13717.727221689856 12596.770242921833 15334.719648290707 16293.587756905588 12413.606504107081 12560.44276654019 13219.507812757181 16418.850980338502 0.9506448119612043 0.8479744494273136 0.8354864319139489 0.7672138725180225 0.9339703287796426 0.9923707679920528 0.7560581747755868 0.7650013257067296 0.8051420789790638 1.0 14.0030655478972 -10.51786644906679 4.621025256802181 1.0000027239782445 0.8488135905652351 0.2431401198126112 0.07912144212398846 25842075.565722775 29409436.08960642 709.7046470677393 0.02038006891485399 3.034824286780092e-11 10.51786644906679 -0.15118913341300944 VTSLANLIS(ph)PVR ddPTM_A459_Selumetinib_30min_R1 2 VTSLANLISPVR 12 0 Q7Z628;Q7Z628-2 Q7Z628 NET1 Neuroepithelial cell-transforming gene 1 protein 1 VTSLANLIS(1)PVR;VTSLANLIS(1)PVR 139.77 0.0011302 27501000.0 2547.43 2670.7 3716.4 3780.9 3083.8999999999996 2682.8999999999996 2875.7 2515.0 1568.51 2185.92 True False 2606.780162564092 2358.0132024252534 3211.7332927239463 3120.6367912830274 2804.961789506766 2655.912461878297 2658.783633760648 2448.2940301286676 2661.6469105621854 2466.50412466389 1.0568724116442811 0.956014295231142 1.3021398426250792 1.2652063947828494 1.1372216091019096 1.0767922239903889 1.0779562892978987 0.9926170427395075 1.0791171536860444 1.0 11.268251984573922 -7.042029843331142 2.0330738324431277 1.033664649479346 1.1478889213796615 0.22159507345399643 0.09453434716624526 0.5780290421251142 4.7625349565763555 0.04723962188681253 0.03562491667925512 9.077581497911473e-08 7.042029843331142 0.11422427190031548 VTSLANLIS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 VTSLANLISPVR 12 0 Q7Z628;Q7Z628-2 Q7Z628 NET1 Neuroepithelial cell-transforming gene 1 protein 1 VTSLANLIS(1)PVR 88.706 0.026781 7203600.0 16787.0 13885.0 17831.0 17939.0 19696.0 16796.0 14645.0 17574.0 12774.0 16065.0 True False 15854.045743685398 14949.934852688159 16683.772872924896 15495.677253498934 17221.612395525928 19109.496541092532 15326.021518516976 17625.137430467676 15329.1569353813 15601.16170811724 1.0162093080181704 0.9582577972324811 1.0693929840009526 0.993238679491193 1.1038673092251567 1.224876512314459 0.9823641216758167 1.1297323725128345 0.9825650949701766 1.0 13.929365839927907 -6.258059176947857 24.965626331559537 1.0803594625092248 1.0099247901253843 0.13091781171724348 0.07484905910919794 538.3358276864985 3976064.966319052 0.022084117404900933 0.027295729158059685 5.520022183569936e-07 6.258059176947857 -0.07043467238384049 VTSLRS(ph)PGASVSSSLTSLCSSSSDPAPSDR ddPTM_A459_Selumetinib_30min_R1 2 VTSLRSPGASVSSSLTSLCSSSSDPAPSDR 30 1 Q9P206-2;Q9P206;Q9P206-3 Q9P206-2 KIAA1522 Uncharacterized protein KIAA1522 1 VT(0.035)S(0.113)LRS(0.757)PGAS(0.004)VS(0.041)S(0.041)S(0.006)LT(0.001)S(0.001)LCSSSSDPAPSDR;VT(0.184)S(0.184)LRS(0.436)PGAS(0.011)VS(0.121)S(0.046)S(0.018)LT(0.001)SLCSSSSDPAPSDR 68.961 0.00017883 11464000.0 868.4300000000001 818.77 1349.15 1594.5 1259.6 992.95 1462.6399999999999 1017.47 776.23 874.4000000000001 True False 888.6627293293767 722.908027764154 1165.9428403504776 1316.050507471974 1145.6694024004426 982.9618245264658 1352.3118872217806 990.4833903916557 1317.2056164039025 986.6377573772625 0.9006980755446369 0.7326985232004803 1.181733449416992 1.333874056239623 1.161185444033611 0.9962742832176135 1.3706265314805854 1.003897715230984 1.335044809054718 1.0 9.94637668827541 -5.269458998830873 24.729382453210135 1.1790631180141888 0.8166982954777285 0.50882211197523 0.13985357112057703 335.68004203681306 1035109.4142733035 0.03438001451968401 0.07366858427559306 5.377011943865054e-06 5.269458998830873 -0.3623648225364603 VTSSITIYPSDS(ph)SSPR ddPTM_A459_Selumetinib_30min_R2 1 VTSSITIYPSDSSSPR 16 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 VTSSITIYPSDS(0.379)S(0.379)S(0.242)PR 150.12 0.00023929 5310400.0 23844.0 23897.0 27445.0 23847.0 27811.0 21077.0 22005.0 22031.0 20872.0 27924.0 True False 22518.845935094683 25729.823059034123 25679.218579856635 20598.997461630475 24317.133546505473 23980.165432043792 23028.2761020803 22095.10656257161 25046.983212406314 27117.761564734883 0.830409467290957 0.9488181020255855 0.9469520011286997 0.7596127509439535 0.8967234809722839 0.8842973773775135 0.8491953160332847 0.8147835694265064 0.9236375632485279 1.0 14.726950475695638 -8.532648193240568 15.083061244870112 1.0000000048068858 0.8692617500289924 0.36558833247755984 0.05499831091436232 5.641544309365381 8712.413321751008 0.053874895013318706 0.013910649293828585 2.9332684211802487e-09 8.532648193240568 -0.13073825477789336 VTSSITIYPSDSS(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 VTSSITIYPSDSSSPR 16 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 VTSSITIYPSDS(0.134)S(0.732)S(0.134)PR 180.56 1.0095e-06 4672700.0 21013.0 22006.0 20890.0 25953.0 26808.0 18261.0 20017.0 18677.0 18265.0 22509.0 True False 19845.181581703782 23693.789439557477 19545.960143312277 22418.15662857783 23440.139373439222 20776.28699314663 20947.830162933024 18731.3469778562 21918.510366740207 21859.10668459452 0.9078679137281452 1.083932192721122 0.8941792738990353 1.0255751505333615 1.072328330322801 0.9504636805578601 0.9583113557744914 0.856912738847528 1.0027175713537988 1.0 14.415946823192415 -6.964322768345711 24.99769383047658 0.9442507914204268 0.9989063839591776 0.08238591340152535 0.06851214317846668 363.3645901171645 254594.94954910918 0.02322973176006375 0.020486625445221274 1.0856184903441165e-07 6.964322768345711 0.05465559253875085 VTSSITIYPSDSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VTSSITIYPSDSSSPR 16 0 Q86V48-2;Q86V48-3;Q86V48 Q86V48-2 LUZP1 Leucine zipper protein 1 1 VTSSITIYPSDS(0.007)S(0.018)S(0.975)PR 244.05 6.8685e-22 8301400.0 37222.0 39626.0 41714.0 46299.0 42118.0 31488.0 35721.0 31843.0 28854.0 44497.0 True False 35153.35025147186 42665.18678232774 39030.16665476918 39992.99632977017 36826.760300302645 35825.18618039543 37382.09727981869 31935.657858107574 34625.60624812052 43212.25599290961 0.8135041655135968 0.9873399525664286 0.9032198333077857 0.9255012359533447 0.8522295227156222 0.829051512290257 0.8650808994085487 0.739041670570212 0.8012913339632625 1.0 15.399152931579197 -6.390642986865967 3.8045449995029696 0.8323064874891972 0.9127405040321892 0.11791463615404807 0.07389593647583295 0.38753156299218844 9.889237259544219 0.022896651200980455 0.026094007788352226 4.0677758454124375e-07 6.390642986865967 0.08043401654299198 VTSSMS(ph)SPSMQPK ddPTM_A459_Selumetinib_30min_R1 3 VTSSMSSPSMQPK 13 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VTSSMS(0.929)S(0.07)PSMQPK;VTSSMS(0.5)S(0.5)PS(0.001)MQPK;VTS(0.011)S(0.078)MS(0.451)S(0.23)PS(0.23)MQPK 240.73 7.8018e-18 64723900.0 10905.9 13908.400000000001 14071.9 15519.4 13293.4 10727.599999999999 12462.2 11688.7 6506.6 11556.5 True False 11159.986250812675 12279.998062160268 12161.013271413758 12809.228125218271 12091.014317140385 10619.690083881467 11522.166220625222 11378.677705751466 11041.224976738376 13039.889344842553 0.8558344289345212 0.9417256341225908 0.9326009561748005 0.9823111060589244 0.9272328926566037 0.8144003221991829 0.8836092021886972 0.8726053883464803 0.8467268919812825 1.0 13.670644006608912 -6.562573226367401 24.935212630016444 0.874992897379736 0.9325804922483072 0.13601918886541076 0.053501280419183526 231.56551087059105 145462.98295727308 0.016859717152847245 0.0168597371487656 2.7379579484121867e-07 6.562573226367401 0.057587594868571235 VTSSMS(ph)SPSMQPK ddPTM_A459_Selumetinib_30min_R2 7 VTSSMSSPSMQPK 13 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VTSS(0.001)MS(0.5)S(0.5)PSMQPK;VTSSMS(0.945)S(0.055)PSMQPK;VTSSMS(0.5)S(0.5)PSMQPK;VTSS(0.002)MS(0.794)S(0.107)PS(0.097)MQPK;VTS(0.001)S(0.005)MS(0.975)S(0.009)PS(0.009)MQPK;VTSS(0.001)MS(0.513)S(0.24)PS(0.246)MQPK;VTS(0.002)S(0.01)MS(0.915)S(0.055)PS(0.017)MQPK 298.91 6.9600999999999966e-74 167482300.0 650013.0 560536.0 612225.0 643773.0 647167.0 490957.0 560688.0 531667.0 431897.0 516877.0 True False 613887.8796682053 603527.3087926846 572835.1100401805 556090.0068296314 565864.0957136136 558581.8702860894 586761.102982194 533214.0629477896 518288.46821045765 501953.41800227284 1.2229977078578746 1.2023572051659022 1.1412116931487588 1.1078518182878743 1.1273239217409838 1.1128161503694753 1.1689552893522426 1.062277980036337 1.0325429604069571 1.0 18.937193960654064 -1.5228787452888772 0.09928881308570998 0.9220576520067245 1.772231760083327 0.7914167552994333 0.030916289991302654 64.41639627795519 0.4555039890569916 0.448829043485725 7.457927857650432 0.0299999999994101 1.5228787452888772 0.8501741080766025 VTSSMSS(ph)PSMQPK ddPTM_A459_Selumetinib_30min_R1 1 VTSSMSSPSMQPK 13 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VTSSMS(0.299)S(0.659)PS(0.042)MQPK 92.792 0.017979 50245000.0 3460.6 3961.0 4626.9 4676.8 4554.0 3663.5 4379.5 3762.3 2178.7 3439.5 True False 3541.2252468445836 3497.2442785810563 3998.5923937424445 3860.084674408857 4142.091504074003 3626.64851619186 4049.1507890443227 3662.5115823272686 3697.094774047873 3880.993328567125 0.9124533198185154 0.9011209199558841 1.0303012799093725 0.9946125508631092 1.0672761206737957 0.9344639913438939 1.0433284590415108 0.9437046838932546 0.9526155963305539 1.0 11.922210237792818 -5.249479067077191 24.408763806317662 0.9957962088274722 0.9067870985230181 0.4273587986956975 0.04120960128312371 508.53175263586724 1037811.440706606 0.010346698739556568 0.02688477600677037 5.630162540313643e-06 5.249479067077191 -0.08900911030445413 VTSSMSS(ph)PSMQPK ddPTM_A459_Selumetinib_30min_R2 3 VTSSMSSPSMQPK 13 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VTSSMS(0.097)S(0.903)PSMQPK;VTSS(0.001)MS(0.4)S(0.56)PS(0.038)MQPK;VTSS(0.004)MS(0.119)S(0.438)PS(0.439)MQPK 270.21 3.1407999999999997e-38 110619300.0 247377.0 209365.0 224101.0 233423.0 235299.0 184486.0 201161.0 202155.0 154519.0 173801.0 True False 233628.77666859244 225422.62228542016 209682.58564271958 201630.38472286536 205738.63602025073 209897.27190283392 210515.38509295927 202743.2375814381 185427.11762158942 168782.91354077103 1.3841968465140715 1.3355772664213863 1.2423211641744107 1.1946137229948914 1.218954168429808 1.2435931309606842 1.2472553096561365 1.2012071206038497 1.098613086666488 1.0 17.364809337026443 -1.5228787452805956 0.028662102875551643 4.4051992679451925e-16 2.9628709975360086 0.8375170686376023 0.04152756180770457 662.9517507971353 1.4636010228536749 49.26343919774071 114.6474958807885 0.029999999999982173 1.5228787452805956 2.962870997536008 VTSSMSSPS(ph)MQPK ddPTM_A459_Selumetinib_30min_R2 2 VTSSMSSPSMQPK 13 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 1 VTSSMS(0.005)S(0.313)PS(0.682)MQPK;VTSSMS(0.017)S(0.315)PS(0.668)MQPK 101.38 0.025877 6999200.0 76646.0 62394.0 66857.0 72130.0 77804.0 55810.0 61105.0 57643.0 48426.0 57737.0 True False 72386.32215824812 67179.41917166917 62555.49340839765 62305.76956880975 68029.56594341478 63497.320907262125 63946.50357726047 57810.73158668766 58112.55313549201 56069.98279125831 1.290999542977096 1.1981351844135557 1.115668139961521 1.1112143515500355 1.2132974286202394 1.1324654966215146 1.1404766043058276 1.0310460019563399 1.0364289454455147 1.0 15.774941006568406 -1.5228787452927932 0.12072017512168033 0.9357485865283509 1.9307556206964993 0.7122599436645998 0.04599783576215183 57.79346790770969 0.48090716728622945 0.3451557326106335 9.67451385125161 0.029999999999139593 1.5228787452927932 0.9950070341681484 VTSSVPLPSGSTS(ph)SPGR ddPTM_A459_Selumetinib_30min_R1 1 VTSSVPLPSGSTSSPGR 17 0 Q15036-2;Q15036 Q15036-2 SNX17 Sorting nexin-17 1 VTSSVPLPSGST(0.003)S(0.64)S(0.357)PGR 265.6 4.958299999999999e-41 38409000.0 3094.0 4859.5 3693.9 4289.6 4223.4 3380.8 3588.0 2976.0 1760.3 2871.6 True False 3166.0841801240067 4290.54748087974 3192.288669140293 3540.5018857646774 3841.39421570183 3346.792221520798 3317.3542712846265 2897.066812589626 2987.1005327748094 3240.1978317526837 0.9771268127821111 1.324162197392405 0.9852141242294223 1.092680777410913 1.1855431103797598 1.0328974943207265 1.0238122619476624 0.8941018305115488 0.9218883191335977 1.0 11.661866184863161 -7.3082044064493195 1.9043315850324765 0.9342555605980095 1.1147501161319002 0.35284301971382714 0.09808807256255367 0.3561078560303272 2.5177216936217155 0.0501688772714279 0.030405769866730405 4.9180800524855275e-08 7.3082044064493195 0.1804945555338907 VTSSVPLPSGSTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R1 3 VTSSVPLPSGSTSSPGR 17 0 Q15036-2;Q15036 Q15036-2 SNX17 Sorting nexin-17 1 VTSSVPLPSGS(0.002)T(0.002)S(0.332)S(0.664)PGR;VTSSVPLPS(0.229)GS(0.229)T(0.229)S(0.072)S(0.242)PGR;VTSSVPLPS(0.039)GS(0.039)T(0.039)S(0.039)S(0.846)PGR 235.02 4.1678999999999995e-17 379052000.0 11224.0 16519.2 13696.5 16770.3 15240.1 13958.8 15192.9 11825.0 6954.7 11532.699999999999 True False 11485.497361897817 14585.124384432276 11836.59052948917 13841.681922519425 13861.635645858189 13818.387145576344 14046.887321126032 11511.36258698667 11801.617948809264 13013.034383010936 0.8826148478399947 1.1208088717166358 0.9095949631042501 1.0636782717327116 1.0652116361081114 1.061888160659656 1.0794474914678498 0.8846024876423317 0.9069074592023497 1.0 13.667669788867798 -7.765512192185806 24.99959964716895 0.9218162205408172 1.0296505639596587 0.2458757696107614 0.07616036651126061 130.02781381015126 798108.8522866364 0.03786409385410662 0.019236575383035498 1.7158835385105963e-08 7.765512192185806 0.10783434341884146 VTSSVPLPSGSTSS(ph)PGR ddPTM_A459_Selumetinib_30min_R2 4 VTSSVPLPSGSTSSPGR 17 0 Q15036-2;Q15036 Q15036-2 SNX17 Sorting nexin-17 1 VTSSVPLPS(0.002)GS(0.002)T(0.013)S(0.226)S(0.758)PGR;VTSSVPLPS(0.001)GS(0.001)T(0.001)S(0.207)S(0.791)PGR;VTSSVPLPSGSTS(0.013)S(0.987)PGR;VTSSVPLPSGST(0.004)S(0.039)S(0.958)PGR 310.98 3.7701999999999985e-103 461171000.0 288709.0 322269.0 360491.0 351271.0 410438.0 278519.0 256841.0 265891.0 243708.0 325848.0 True False 272663.70957369806 346985.9960418404 337297.4015329236 303427.2838237255 358875.10907772504 316882.4641062484 268784.61542078655 266664.69878937554 292456.40977046423 316439.92158522236 0.8616602741138821 1.0965304071104427 1.0659129222482886 0.9588780148335602 1.134101877158613 1.001398504078781 0.8494017255291176 0.8427024550300252 0.9242083246177932 1.0 18.271572093968892 -7.145901266171458 5.465466635855975 0.8916908934021711 1.029776614106849 0.3194023736477254 0.08192302924141051 0.2369688038241773 9.77069954892657 0.030722361184963274 0.02367669659235307 7.146587803093413e-08 7.145901266171458 0.13808572070467784 VTTEIQLPSQS(ph)PVEEQSPASLSSLR ddPTM_A459_Selumetinib_30min_R1 3 VTTEIQLPSQSPVEEQSPASLSSLR 25 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 VT(0.001)T(0.003)EIQLPS(0.229)QS(0.765)PVEEQS(0.001)PASLSSLR;VTTEIQLPS(0.046)QS(0.954)PVEEQSPASLSSLR;VTTEIQLPSQS(1)PVEEQSPASLSSLR 151.53 2.7404e-10 63575100.0 10476.2 11475.6 11988.099999999999 12174.2 12124.099999999999 10673.6 10813.6 10444.5 5906.16 7951.4 True False 10720.275076863329 10132.031417138302 10360.181865919692 10048.204508037186 11027.477295683702 10566.233274853395 9997.921445920698 10167.477931482643 10022.322151140863 8972.039643194832 1.1948537348466253 1.1292896398226804 1.1547186902788316 1.1199465124586927 1.229093688194734 1.177684639731584 1.1143420942755178 1.1332404153156561 1.1170617328627894 1.0 13.13122027968661 -8.951713165113379 0.701844047654084 0.9980791817123912 1.163279564869136 0.692386145484907 0.0322648560335886 0.872091512668619 0.7633833573755785 0.03669694601319566 0.012558144238019885 1.1176011368648548e-09 8.951713165113379 0.1652003831567449 VTTEIQLPSQS(ph)PVEEQSPASLSSLR ddPTM_A459_Selumetinib_30min_R2 1 VTTEIQLPSQSPVEEQSPASLSSLR 25 0 E9PMS6;F8WD26;J3KP06;Q8WWI1-4;Q8WWI1-2;Q8WWI1;A0A0A0MTE2;E9PMT2;Q8WWI1-5;H0Y424;Q8WWI1-3;E9PMP7 E9PMS6;Q8WWI1-3 LMO7 LIM domain only protein 7 1 VT(0.055)T(0.055)EIQLPS(0.117)QS(0.748)PVEEQS(0.02)PAS(0.002)LS(0.001)S(0.001)LR 48.76 0.030027 4458100.0 22727.0 19004.0 19511.0 25562.0 26901.0 23069.0 18831.0 20452.0 19318.0 22154.0 True False 21463.924323389398 20461.545692508887 18255.683501970598 22080.411503090436 23521.45588200867 26246.54535046819 19706.678812918606 20511.51193398914 23182.139790018457 21514.35645699529 0.9976558846318875 0.9510647336074937 0.8485349556451571 1.026310572999319 1.0932911671806378 1.2199549358091188 0.915978075026784 0.9533871940343314 1.0775195547381058 1.0 14.393012066213215 -5.932362589422852 10.2900460482823 1.0449633828331382 0.9344851461299432 0.25539964123569736 0.08527407865499934 0.6289662406796854 91.54819194748671 0.025718828777401868 0.03818033017884715 1.1685233916490925e-06 5.932362589422852 -0.11047823670319501 VTTHPLAK ddPTM_A459_Selumetinib_30min_R2 1 VTTHPLAK 8 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 87.181 0.046128 5522600.0 129810.0 107560.0 102550.0 122310.0 137450.0 108490.0 122880.0 139630.0 111050.0 137170.0 False True 122595.67987060225 115809.50614008927 95952.04464799768 105651.16700348159 120182.30218140947 123433.5127258354 128594.16348210082 140036.30018300907 133263.10299624954 133209.54568953876 0.9203220327492638 0.8693784333594049 0.7203090750840464 0.7931200910309734 0.9022048799829189 0.9266116184609803 0.9653524664201268 1.051248237940702 1.000402053069347 1.0 17.02333794292346 -6.921849613111837 1.4129511114942503 1.0147678896036756 0.8245733148326765 0.6886384906198032 0.05316662289058609 0.25112002214030427 1.0321990715618228 0.0290823493273982 0.022879405691864686 1.1971550087093923e-07 6.921849613111837 -0.1901945747709991 VTVAGLAGKDPVQCSR ddPTM_A459_Selumetinib_30min_R2 2 VTVAGLAGKDPVQCSR 16 1 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 ; 116.79 0.0053353 5327400.0 20004.0 18681.9 13132.9 18111.2 21220.7 16268.5 16708.9 12315.6 12152.599999999999 23589.5 False True 18892.257762356752 20114.74165822361 12287.943512020382 15644.423316437365 18554.765950534987 18509.338204260766 17485.896958057234 12351.436357042667 14583.45957201462 22908.40984211838 0.8246865623829678 0.8780505411266715 0.5363944331669986 0.6829117963340356 0.8099543389703558 0.8079713228384068 0.7632959720280734 0.5391660286404457 0.6365985100023015 1.0 14.483589698841987 -5.148653330844672 20.486028456250427 0.7115118794994246 0.8513944179814807 0.1299983882315625 0.13157967464283724 11.364416385429367 2044.7427011366688 0.03340082789312462 0.08837131790361602 7.10144404060036e-06 5.148653330844672 0.13988253848205612 VTVDTGVIPASEEKAET(ph)PTAAEDDNEGDKK ddPTM_A459_Selumetinib_30min_R2 1 VTVDTGVIPASEEKAETPTAAEDDNEGDKK 30 2 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 VTVDT(0.009)GVIPAS(0.32)EEKAET(0.623)PT(0.049)AAEDDNEGDKK 70.112 0.00034165 9802700.0 34064.0 27634.0 22577.0 24006.0 21196.0 18206.0 24895.0 21631.0 15103.0 19649.0 True False 32170.85924899622 29753.438942685254 21124.420399978986 20736.34138734016 18533.16898535579 20713.71124238692 26052.666828506648 21693.942628795165 18124.02201307842 19081.682315766928 1.6859550807223056 1.5592670735378715 1.1070523054733057 1.0867145277964307 0.9712544564292475 1.0855285660673362 1.3653233712511654 1.1368988472714359 0.9498125853454122 1.0 14.219900750139262 -5.2052338640486155 3.4677832141384277 1.095571176664998 1.6615857106319918 0.791322195960183 0.11056009957923447 0.11064004811143222 2.658390939629482 0.03124609327182593 0.09521069714901685 6.233990497602032e-06 5.2052338640486155 0.5660145339669937 VTVEST(ph)PDLEK ddPTM_A459_Selumetinib_30min_R2 1 VTVESTPDLEK 11 0 Q14244-5;Q14244-3;Q14244-6;Q14244;Q14244-7;A0A087WZ40;Q14244-2;Q14244-4 Q14244-5 MAP7 Ensconsin 1 VTVES(0.36)T(0.64)PDLEK 198.52 4.6102e-05 2640200.0 35910.0 30037.0 31312.0 35793.0 35556.0 31913.0 37187.0 31747.0 29887.0 31611.0 True False 33914.265959119715 32340.7413158224 29297.42000992789 30917.931653631047 31089.137405326954 36308.72607262958 38916.26918464258 31839.378514001215 35865.23511255212 30698.308294758437 1.1047600940573779 1.0535023951578595 0.9543659451400538 1.0071542495685375 1.0127312914710433 1.182759835623551 1.2677007739637338 1.0371704593063067 1.1683130799320272 1.0 14.905871534102252 -6.752330827401964 24.99392665215969 1.1420439810202576 1.022920230381224 0.30137397778978725 0.0787385150721276 223.86732226691677 614292.8606254146 0.026253593724822222 0.025900577608276548 1.7687610766705938e-07 6.752330827401964 -0.11912375063903369 VTVPTS(ph)GNTIESPLHENISNSTSFK ddPTM_A459_Selumetinib_30min_R2 1 VTVPTSGNTIESPLHENISNSTSFK 25 0 Q8N302;A0A2R8YFF1 Q8N302 AGGF1 Angiogenic factor with G patch and FHA domains 1 1 VT(0.003)VPT(0.166)S(0.466)GNT(0.054)IES(0.305)PLHENIS(0.004)NS(0.001)T(0.001)S(0.001)FK 46.92 0.037292 2624400.0 6823.8 5250.1 5672.8 7065.3 8939.7 6997.6 5694.2 7523.1 5767.4 8475.2 True False 6444.5605138357305 5652.76578826778 5307.818224077634 6102.993951677683 7816.614964067994 7961.455882111763 5958.991582843242 7544.990975483754 6921.041154620169 8230.49895478589 0.7830096995624224 0.6868071813533002 0.6448962879694228 0.7415095956155733 0.9497133778897779 0.9673114504780196 0.7240134061833753 0.9167112488479784 0.8409017718902335 1.0 13.006764177979157 -6.1329545157175405 5.145289162892946 0.8895893168904371 0.701897026200119 0.5691165596802458 0.07919534447963139 0.1751375643630517 6.600991741774648 0.02372749120815696 0.031040675841835667 7.362842055551383e-07 6.1329545157175405 -0.18769229069031812 VTVPTSGNTIES(ph)PLHENISNSTSFK ddPTM_A459_Selumetinib_30min_R2 1 VTVPTSGNTIESPLHENISNSTSFK 25 0 Q8N302;A0A2R8YFF1 Q8N302 AGGF1 Angiogenic factor with G patch and FHA domains 1 1 VTVPT(0.006)S(0.006)GNT(0.001)IES(0.987)PLHENISNSTSFK 101.0 2.1167e-06 5094000.0 30825.0 18851.0 29971.0 37242.0 35206.0 28975.0 36822.0 38432.0 43178.0 28119.0 True False 29111.869902251896 20296.811084481425 28042.698489957485 32169.575353966622 30783.107534366663 32966.043241138155 38534.29596140882 38543.83075723991 51814.80649412037 27307.131408064033 1.066090372775476 0.7432787714379842 1.0269368126187077 1.1780649850488019 1.1272918811705042 1.2072320138102457 1.4111440482550761 1.4114932169644734 1.8974825923611665 1.0 14.736990147672204 -6.651158484645596 0.8505540657555143 1.4810372703482504 0.927762536383525 0.42436643859122913 0.22476296483667765 0.5320304195673768 0.84698570117334 0.13423918510451627 0.14217745303482662 2.232757286570628e-07 6.651158484645596 -0.5532747339647254 VTVTS(ph)SPIR ddPTM_A459_Selumetinib_30min_R2 1 VTVTSSPIR 9 0 Q5T534;Q5T532;Q9H2G9-2;Q9H2G9 Q5T534 BLZF1 Golgin-45 1 VTVT(0.123)S(0.754)S(0.123)PIR 106.88 0.012912 6128200.0 79781.0 62731.0 86521.0 79133.0 80043.0 74726.0 81475.0 79006.0 70332.0 61317.0 True False 75347.09140864751 67542.26598804323 80954.33305694217 68354.94888796091 69987.28274650083 85018.82820491071 85263.74893964975 79235.89437985262 84400.36524027212 59546.61888930127 1.265346258344571 1.1342754172761023 1.3595118340377712 1.147923260177619 1.1753359645256942 1.4277691964839 1.4318822887015181 1.3306531228440397 1.4173829986413606 1.0 15.86173197243949 -6.751243886606872 24.996635847194195 1.349099894664519 1.216049364518344 0.11914507208629921 0.1326321262743784 337.2022197982136 826729.0397722741 0.04141048482551172 0.040951792272079006 1.7731934295993606e-07 6.751243886606872 -0.13305053014617507 VTVTSS(ph)PIR ddPTM_A459_Selumetinib_30min_R2 1 VTVTSSPIR 9 0 Q5T534;Q5T532;Q9H2G9-2;Q9H2G9 Q5T534 BLZF1 Golgin-45 1 VTVT(0.011)S(0.075)S(0.913)PIR 117.01 0.0076664 8665300.0 81102.0 65714.0 74891.0 81240.0 84294.0 76063.0 74279.0 90412.0 70581.0 65496.0 True False 76594.67551702942 70754.05249618652 70072.59459515559 70174.9718531832 73704.23412207878 86539.98781883322 77733.12068104623 90675.0839514876 84699.17219791359 63604.96030095531 1.204224877346225 1.1123983437990421 1.101684432528498 1.1032940123088044 1.158781229849644 1.3605855173772263 1.2221235625844533 1.4255976817286955 1.3316441327397772 1.0 15.95685165956443 -6.636279193038662 6.024010343728221 1.2911279273932332 1.1276823606324538 0.2534822917209798 0.11026546853376236 0.23980247129445992 11.779716895550157 0.03476437743056227 0.034679531943114975 2.3105789206174945e-07 6.636279193038662 -0.16344556676077948 VTVVDVNES(ph)R ddPTM_A459_Selumetinib_30min_R1 1 VTVVDVNESR 10 0 O60701;O60701-2;E7ER83;E7ETF4;E7EV97;E7ER95;D6RHF4;E9PBD2 O60701 UGDH UDP-glucose 6-dehydrogenase 1 VTVVDVNES(1)R 102.97 0.014721 3225400.0 1883.4 2573.7 2035.4 2276.3 2460.9 2431.7 2476.3 2589.6 1356.1 2189.3 True False 1927.2795555415507 2272.3700075193296 1759.0038596519005 1878.7869364430574 2238.3120295071826 2407.239305806944 2289.510697319433 2520.9153957937156 2301.2026543747766 2470.3179805878794 0.7801746862899416 0.9198694359900005 0.71205564363552 0.7605445741021359 0.9060825558070525 0.9744653622421822 0.926808093253882 1.020482146672387 0.9315410697966675 1.0 11.270481042865061 -6.464196488444082 3.652072583107815 0.9680292507156072 0.7971921654310077 0.6919007621441366 0.05574852131229804 0.14419115129044813 3.8271724048862157 0.018639134576475255 0.02059677184283604 3.4340254666632793e-07 6.464196488444082 -0.1708370852845995 VVAPVESHVPESNQAQGES(ph)PAANEGTTVQHPEAPQEEK ddPTM_A459_Selumetinib_30min_R1 1 VVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEK 38 0 Q96T58 Q96T58 SPEN Msx2-interacting protein 1 VVAPVES(0.002)HVPES(0.257)NQAQGES(0.717)PAANEGT(0.012)T(0.012)VQHPEAPQEEK 58.326 0.0001157 6439800.0 743.18 853.37 934.28 916.83 1067.3 1053.0 903.07 742.01 518.56 711.36 True False 760.494648023452 753.4570436790497 807.4099076326902 756.7228515305919 970.7629034471194 1042.4077760475031 834.9507028341715 722.3294844118376 879.9584458761033 802.6699852331762 0.947456192475576 0.9386884492263278 1.0059051945216775 0.9427571298941287 1.209417221655687 1.2986754148340092 1.0402166745921335 0.8999084277481739 1.0962892123348484 1.0 9.648663140743134 -6.228449257244207 24.81234524733784 1.0936160918395668 0.9606438684232431 0.2796571434805618 0.10374439394265111 904.7435073641626 680470.3515196402 0.034241786427801506 0.044202254889301455 5.909500078524343e-07 6.228449257244207 -0.13297222341632364 VVASGGT(ph)VTGDT(ph)MVNIT(ph)VK ddPTM_A459_Selumetinib_30min_R2 1 VVASGGTVTGDTMVNITVK 19 0 Q6V0I7-3;Q6V0I7 Q6V0I7-3 FAT4 Protocadherin Fat 4 3 VVAS(0.07)GGT(0.634)VT(0.452)GDT(0.844)MVNIT(1)VK 100.39 0.0012239 0.0 8674.3 11400.0 9094.9 10284.0 9370.2 6542.9 5810.0 4669.6 4455.0 9456.2 True False 8192.217131974161 12274.343343222547 8509.7440357784 8883.301459110484 8193.031705349162 7444.125084467394 6080.17651229659 4683.187762906106 5346.124483100333 9183.174935841782 0.892089847923954 1.3366121661600918 0.9266668766773687 0.9673453376608457 0.8921785507288871 0.8106265138664729 0.6620996065931142 0.5099747958222707 0.5821651575246047 1.0 13.16477731327848 -6.548339342678217 1.0619625885229722 0.6492333581447709 1.0813785361826644 0.45637641455061306 0.16586374184902627 0.395739139202855 0.9544072300916281 0.08006007856289493 0.09007882538184118 2.829180508184346e-07 6.548339342678217 0.43214517803789354 VVASGPGLEHGK ddPTM_A459_Selumetinib_30min_R2 1 VVASGPGLEHGK 12 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 125.36 0.0040577 7797200.0 77962.0 72819.0 89702.0 92657.0 102730.0 74937.0 65405.0 84271.0 74765.0 76064.0 False True 73629.18414661346 78403.98315001074 83930.670980153 80036.95675775962 89824.13898214747 85258.89153964345 68446.46209754876 84516.21465818488 89720.08910864104 73867.83468199387 0.9967692225390413 1.0614089811559428 1.1362275791822019 1.0835156750204502 1.2160115342333586 1.154208620121178 0.9266071273405468 1.1441544891904984 1.2146029390856279 1.0 16.17265866751157 -4.922932332949075 2.852459968533126 1.1124251189316492 0.9917235410362365 0.14369015677621066 0.08523139938202598 0.6322481537817654 8.833091318545705 0.02251012017034763 0.15377039677612916 1.1941741532209524e-05 4.922932332949075 -0.12070157789541269 VVDES(ph)DETENQEEK ddPTM_A459_Selumetinib_30min_R2 2 VVDESDETENQEEK 14 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 1 VVDES(0.993)DET(0.007)ENQEEK;VVDES(1)DETENQEEK 210.37 2.9032999999999998e-30 0.0 25642.0 23864.0 26210.0 26071.3 26892.0 23349.7 25568.0 28067.0 22989.8 22787.5 True False 24216.92029305898 25694.29206514587 24523.67713529032 22520.34396449895 23513.586542469704 26565.909227527278 26756.96266203085 28148.670323258015 27588.402388682403 22129.565665964623 1.0943242474164199 1.1610843363574828 1.1081861029476892 1.017658651978667 1.062541709918587 1.2004713345271738 1.2091047364378773 1.2719937999755144 1.2466761799628765 1.0 14.433687515382992 -6.7714094029980965 24.26136856877833 1.2041148391195242 1.0899063483681628 0.26773424291194914 0.07714181264765943 166.1534770247598 404319.9458148145 0.026660742018245222 0.02380309560972686 1.6927413258152829e-07 6.7714094029980965 -0.11420849075136141 VVDLMAHMASK ddPTM_A459_Selumetinib_30min_R1 2 VVDLMAHMASK 11 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 148.18 0.00091797 38618000.0 26050.0 27989.0 22714.0 24727.0 25746.0 22279.0 26820.0 25670.0 14963.0 22365.0 False True 26656.914315523714 24712.034868266914 19629.56355907108 20408.89363327658 23417.278845825476 22054.893487713518 24796.945807094115 24989.148212088625 25391.11814571917 25235.765603548123 1.0563148641615128 0.9792464891492108 0.7778469600427412 0.8087289267898062 0.9279400995281487 0.8739538096126801 0.9826111954220913 0.990227465441951 1.0061560463277248 1.0 14.62318223538283 -7.346235782482883 5.189509982934126 0.995970119862346 0.8985557158630046 0.26084185252511116 0.07466258365278894 0.3468831792192848 15.786686997321372 0.03520815497857029 0.023446646048311162 4.5057201841858965e-08 7.346235782482883 -0.09741440399934131 VVDLMAHMASK ddPTM_A459_Selumetinib_30min_R2 2 VVDLMAHMASK 11 0 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 107.85 0.014487 5077900.0 48771.0 31870.0 37072.0 41821.0 52191.0 41430.0 41226.0 43799.0 40535.0 38618.0 False True 46060.503065781886 34314.32652179849 34686.827880941695 36124.907654751005 45634.29998654006 47136.6064359052 43143.09068776922 43926.447838685235 48643.13264253017 37502.99799838603 1.2281818927586572 0.9149755580413925 0.9249081335426695 0.9632538618994051 1.2168173858661637 1.2568756886565111 1.150390448508301 1.171278302619317 1.2970465093116972 1.0 15.194718309145191 -6.2628478730556845 24.963156345711845 1.1927884768778443 0.9952744261182569 0.3703086116002632 0.11029619583681875 119.40609311849025 2116266.9302904527 0.032712226131876146 0.0391378707119137 5.459490654975578e-07 6.2628478730556845 -0.1975140507595874 VVDLMAHMASKE ddPTM_A459_Selumetinib_30min_R1 2 VVDLMAHMASKE 12 1 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 ; 139.78 0.0015281 99649000.0 22933.0 24120.0 38680.0 38892.0 33340.0 27859.0 27471.0 26849.0 15172.1 16837.4 False True 23467.294280149927 21296.019186916223 33427.46845403138 32100.242293258085 30324.402886655083 27578.763753948122 25398.840352971012 26136.877302156885 25745.945573659425 18998.644300164604 1.235208886980773 1.1209230959038332 1.7594659874621563 1.689606994378013 1.596135092986206 1.4516174584998773 1.3368764608509964 1.3757232826307735 1.355146460289083 1.0 14.21360885435774 -8.898359346840326 0.742159909134949 0.998327637985538 1.4761159975708755 0.3527180872239166 0.18438122111204824 1.6309132550599132 1.6466995820776134 0.2141681749087056 0.07452466046685947 1.2636903036988751e-09 8.898359346840326 0.4777883595853375 VVDLMAHMASKE ddPTM_A459_Selumetinib_30min_R2 1 VVDLMAHMASKE 12 1 P04406;P04406-2;E7EUT5 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 87.21600000000002 0.038997 39897000.0 432340.0 408380.0 437120.0 510900.0 506010.0 326860.0 255820.0 283740.0 210040.0 476890.0 False True 408312.2735941469 439701.4328513354 408996.175100271 441314.5386483419 442440.50001320435 371881.9980603424 267716.1368977134 284565.6364243145 252053.86900794503 463120.94659097685 0.8816536513835632 0.9494311066859921 0.8831303747128756 0.9529142266115332 0.9553454735096721 0.8029910994045025 0.5780695925510734 0.6144520961943007 0.544250634447239 1.0 18.821029484899952 -7.0161560457594305 3.967071309606654 0.6534844195170786 0.9236942722021875 0.4598972919029818 0.12073417156921787 0.1689165611001788 5.988387430544052 0.043778065437142556 0.035486270820269096 9.634827737378044e-08 7.0161560457594305 0.2702098526851089 VVDNS(ph)PPPALPPK ddPTM_A459_Selumetinib_30min_R1 2 VVDNSPPPALPPK 13 0 Q13905-2;Q13905;Q13905-4;Q13905-3 Q13905-2 RAPGEF1 Rap guanine nucleotide exchange factor 1 1 VVDNS(1)PPPALPPK;VVDNS(1)PPPALPPK 138.19 0.0010013 17492700.0 14269.0 16331.2 17073.9 18068.9 16782.9 14383.4 15583.2 14902.9 8262.0 13580.4 True False 14601.43993735923 14419.135511831106 14755.358160219403 14913.505810260478 15264.889658261665 14238.716055082301 14407.746677893705 14507.626680558451 14020.010567395018 15323.576624298012 0.9528741425945091 0.9409771533995028 0.9629186789735755 0.973239223185839 0.9961701522121612 0.9292031752237602 0.9402339304420543 0.9467519911476973 0.914930692170392 1.0 13.903465450696423 VVDNS(ph)PPPALPPK ddPTM_A459_Selumetinib_30min_R2 1 VVDNSPPPALPPK 13 0 Q13905-2;Q13905;Q13905-4;Q13905-3 Q13905-2 RAPGEF1 Rap guanine nucleotide exchange factor 1 1 VVDNS(1)PPPALPPK 97.631 0.013213 4873500.0 59572.0 51257.0 60484.0 67774.0 68966.0 52643.0 58746.0 58898.0 48935.0 53929.0 True False 56261.22672561067 55188.247082768255 56592.52528999995 58543.06428332892 60301.87451613727 59894.095404425745 61477.805402990656 59069.383428911206 58723.36735814026 52371.92964563054 1.0742630089495782 1.0537753230823086 1.0805888893712272 1.1178328673290205 1.151415938350256 1.1436297232065573 1.1738693956662305 1.1278825093632854 1.1212756099591155 1.0 15.676506141466653 -5.73340430843899 2.9710053612693996 1.130293527344399 1.064561624669455 0.1911037925997482 0.04454417514956628 0.3157289279184533 5.690630067273826 0.012118117446271542 0.021749732167670777 1.8475478349892538e-06 5.73340430843899 -0.06573190267494411 VVDRDSEEAEIIR ddPTM_A459_Selumetinib_30min_R1 1 VVDRDSEEAEIIR 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 113.07 0.01323 5777000.0 2496.4 3164.9 2984.2 3068.9 3319.5 2662.6 2741.5 2345.9 1687.2 2510.1 False True 2554.561262851185 2794.3520366779076 2578.9620310372416 2532.9742253877325 3019.251811105323 2635.8166614473703 2534.7064478056864 2283.6791114428784 2863.0551717875674 2832.2957854444962 0.9019401419793011 0.9866031828449606 0.9105553326353953 0.8943183965477713 1.0660086515757345 0.9306290236327521 0.8949299931284872 0.8062996538634757 1.0108602309480341 1.0 11.467756223074131 -9.795077850403688 13.000925404614732 0.9999841581694155 0.9322287663440092 0.07745019378459472 0.06863874707637499 0.0 0.0 0.06690970355615071 0.016227986772986768 1.6029580232011491e-10 9.795077850403688 -0.06775539182540635 VVDRDSEEAEIIR ddPTM_A459_Selumetinib_30min_R2 2 VVDRDSEEAEIIR 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 ; 132.14 0.0040946 8623300.0 369810.0 298280.0 274460.0 266810.0 248230.0 216252.0 303350.0 287170.0 195542.0 246260.0 False True 349257.4406667237 321157.1168786327 256801.5424094536 230470.01772707744 217045.12819564366 246038.75005979635 317456.3760766215 288005.61715644697 234655.86389997855 239149.8339396799 1.4604126413686573 1.3429117285510526 1.0738102476551414 0.9637055310906394 0.907569637913227 1.0288058578449777 1.3274371587341043 1.204289429818671 0.9812085588115655 1.0 17.867555263986063 -5.160487838624479 3.1748870968491967 1.0663387643353692 1.4413919201680758 0.5827940395438738 0.1170799899256416 0.20705808250371766 3.8836707283786054 0.03499661549060765 0.11907552972415648 6.910542804519647e-06 5.160487838624479 0.3750531558327066 VVDVEEQQLEES(ph)GPHDLTETSYLPR ddPTM_A459_Selumetinib_30min_R1 2 VVDVEEQQLEESGPHDLTETSYLPR 25 0 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;K7EPC7 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 VVDVEEQQLEES(1)GPHDLTETSYLPR;VVDVEEQQLEES(1)GPHDLTETSYLPR 167.06 3.3215e-16 23305000.0 2189.77 3186.4 2944.6 2991.1 3272.0 2447.3 2315.5 2310.2 1168.95 2423.0 True False 2240.787380449305 2813.3348066828285 2544.7394935300103 2468.7605349008604 2976.04817771852 2422.6823839706108 2140.839970780255 2248.9259914128197 1983.6227732699608 2734.015652018649 0.8195956664676844 1.029011960705351 0.9307699067674001 0.9029796640257204 1.0885263862776966 0.8861260110862327 0.7830386666585376 0.8225724639697417 0.7255345344513158 1.0 11.416805786942215 -6.998575213632848 24.999788161335456 0.8203695687530356 0.9575032395178433 0.2689998566206534 0.09361932323045197 54.42663499912571 954965.3019639943 0.03143010785941535 0.027511489644067477 1.0032860792090224e-07 6.998575213632848 0.13713367076480776 VVDVEEQQLEES(ph)GPHDLTETSYLPR ddPTM_A459_Selumetinib_30min_R2 2 VVDVEEQQLEESGPHDLTETSYLPR 25 0 P38398-8;P38398-4;P38398;P38398-7;H0Y8B8;B7ZA85;E7EUM2;A0A2R8Y7V5;P38398-6;P38398-5;P38398-3;K7EPC7 P38398-8 BRCA1 Breast cancer type 1 susceptibility protein 1 VVDVEEQQLEES(1)GPHDLTETSYLPR;VVDVEEQQLEES(1)GPHDLTETSYLPR 141.7 1.0717e-08 11194200.0 35403.0 38328.0 42298.0 43814.0 42103.0 37689.0 35368.0 35111.0 26971.0 40320.0 True False 33435.4429894379 41267.63435605559 39576.59273058028 37846.45761663423 36813.64473440433 42880.317643322 37012.68208036244 35213.16719706105 32365.953632704626 39155.85683605897 0.8539065593540252 1.05393260908166 1.0107451586689287 0.966559301079605 0.9401823305396889 1.0951188687520468 0.9452655380606342 0.8993077930715319 0.826592909669098 1.0 15.256940497956412 -7.52164368051181 10.819047946367542 0.9021413314888789 0.9905428216231452 0.18878383575205993 0.07241237485832584 0.13276201255140427 488.02207115065966 0.03179400015429367 0.019264460695753043 3.008543667836192e-08 7.52164368051181 0.08840149013426635 VVDYSQFQES(ph)DDADEDYGR ddPTM_A459_Selumetinib_30min_R1 13 VVDYSQFQESDDADEDYGR 19 0 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 VVDYSQFQES(1)DDADEDYGR;VVDYS(0.001)QFQES(0.999)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR 368.58 1.5543999999999987e-240 400131300.0 44094.69 57390.56 38807.590000000004 45129.58 45926.16999999999 42355.27 50670.24 44601.650000000016 23995.97 42948.51 True False 45122.01048366914 50671.246555052465 33537.732432833094 37248.54604013612 41772.156032423845 41929.2144393082 46848.14300195573 43418.669355422775 40719.40849369332 48461.369612414164 0.9310923493196198 1.045600794206035 0.6920508582622036 0.7686234693332791 0.8619681277378349 0.8652090267908431 0.9667110809421866 0.895943917860307 0.8402446901389758 1.0 15.564547558278365 -7.080578964587318 9.60150402053925 0.9170525227776163 0.8565613584861311 0.09642926765025106 0.09581670116659256 1.4217638519708349 162.0379497304072 0.039316974544360936 0.030465638572879015 8.306556729285921e-08 7.080578964587318 -0.060491164291485156 VVDYSQFQES(ph)DDADEDYGR ddPTM_A459_Selumetinib_30min_R2 18 VVDYSQFQESDDADEDYGR 19 0 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(0.983)DDADEDY(0.017)GR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(0.98)DDADEDY(0.02)GR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYS(0.001)QFQES(0.999)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR;VVDY(0.02)S(0.121)QFQES(0.858)DDADEDYGR;VVDYSQFQES(1)DDADEDYGR 271.73 8.583699999999997e-59 1197174900.0 611980.2 553258.6 656343.9 681029.7999999999 731149.0000000001 593756.2000000001 581494.6 604027.6 545042.3 598744.3 True False 577968.7904348446 595691.7556132114 614115.4480472072 588272.3663980679 639295.5260650081 675540.7269678651 608535.2511096908 605785.2203138475 654065.9897542804 581456.9963344812 0.9940009219570384 1.0244811901283613 1.0561665813957106 1.0117211936678911 1.099471723782055 1.1618068597101592 1.046569660260194 1.0418401087831637 1.1248742278062318 1.0 19.149312970573547 -6.259547271100832 24.96811115128898 1.0836952190708589 1.024268386633052 0.2773319061282562 0.04502463426865568 223.93612355006618 2955052.9840960535 0.01366209559852652 0.016768771044524008 5.50114039686497e-07 6.259547271100832 -0.05942683243780689 VVDYSQFQES(ph)DDADEDYGRDSGPPTK ddPTM_A459_Selumetinib_30min_R1 6 VVDYSQFQESDDADEDYGRDSGPPTK 26 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 VVDYS(0.006)QFQES(0.858)DDADEDY(0.115)GRDS(0.021)GPPTK;VVDYS(0.004)QFQES(0.996)DDADEDYGRDSGPPTK;VVDYS(0.001)QFQES(0.999)DDADEDYGRDSGPPTK;VVDY(0.026)S(0.141)QFQES(0.776)DDADEDY(0.036)GRDS(0.022)GPPTK;VVDYS(0.001)QFQES(0.996)DDADEDY(0.002)GRDSGPPTK;VVDY(0.001)S(0.013)QFQES(0.983)DDADEDY(0.002)GRDSGPPTK 142.55 6.776699999999999e-10 191297000.0 15370.42 14012.730000000001 26244.100000000002 26413.5 23118.81 17404.49 17081.699999999997 16672.64 10220.97 11897.980000000001 True False 15728.520880368991 12372.11305725856 22680.29536852236 21800.878067802427 21027.717717457428 17229.41663261255 15793.213616444427 16230.427426832759 17344.239579887144 13425.201629139434 1.1715668274381963 0.9215588263795501 1.6893821035279442 1.6238771431546746 1.566286920549239 1.2833637146436636 1.1763855808441057 1.2089522284421097 1.29191650591239 1.0 13.712656135333706 -6.9953980865774525 24.06700667326763 1.1928902866713509 1.4001242356126486 0.18390090536692105 0.22139378976814877 170.37941086047528 891035.3216248683 0.08672423478073746 0.07616273617628994 1.0106526368248011e-07 6.9953980865774525 0.20723394894129776 VVDYSQFQES(ph)DDADEDYGRDSGPPTK ddPTM_A459_Selumetinib_30min_R2 4 VVDYSQFQESDDADEDYGRDSGPPTK 26 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 VVDY(0.015)S(0.045)QFQES(0.806)DDADEDY(0.048)GRDS(0.085)GPPT(0.001)K;VVDYS(0.001)QFQES(0.999)DDADEDYGRDSGPPTK;VVDYS(0.002)QFQES(0.998)DDADEDYGRDSGPPTK;VVDY(0.003)S(0.015)QFQES(0.973)DDADEDY(0.008)GRDSGPPTK 112.37 8.0479e-09 191886000.0 122400.0 162963.0 154005.0 154353.0 152650.0 82237.0 69652.0 73937.0 52771.7 140950.0 True False 115597.49800602192 175461.73809136634 144096.48596796594 133329.85512622315 133472.74229168522 93564.4002768414 72890.95601281968 74152.14442907071 63327.514564495104 136880.40726791954 0.8445145679597517 1.2818616016237485 1.0527181270429902 0.9740609177561343 0.9751048010138923 0.6835485234472265 0.5325156278220909 0.5417294257747993 0.4626484960739672 1.0 17.06255643191428 -6.751687795534589 2.3839599105355265 0.5934448398503327 1.054504300557526 0.5534283420097863 0.17069525178345946 0.19391767590017747 2.261152431356929 0.06252072422903321 0.058133989688523575 1.771381907043268e-07 6.751687795534589 0.4610594607071934 VVDYSQFQES(ph)DDADEDYGRDSGPPTKK ddPTM_A459_Selumetinib_30min_R1 1 VVDYSQFQESDDADEDYGRDSGPPTKK 27 2 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 VVDY(0.003)S(0.057)QFQES(0.941)DDADEDYGRDSGPPTKK 87.46799999999998 0.0013675999999999998 0.0 577.8 522.12 1276.8 1259.1 806.42 688.05 628.92 482.13 293.49 482.4 True False 591.2616157969137 460.9899476729974 1103.4175729603742 1039.2218212342182 733.4794533850151 681.1288416994157 581.480058053603 469.3423462210472 498.03109433850966 544.3207389739152 1.0862375314074666 0.8469086600337835 2.0271459342894 1.9092085728595019 1.3475133333476839 1.2513372960644378 1.06826732185464 0.8622532867400793 0.9149588811871012 1.0 9.088313194503591 -7.144049907746444 1.8464379763747092 0.9243676899989357 1.4672124086383187 0.33094214879382555 0.3263632112757045 0.4623638280071362 3.103472631971029 0.1804506912914016 0.12389029929210248 7.177118093640431e-08 7.144049907746444 0.542844718639383 VVDYSQFQES(ph)DDADEDYGRDSGPPTKK ddPTM_A459_Selumetinib_30min_R2 2 VVDYSQFQESDDADEDYGRDSGPPTKK 27 2 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 1 VVDY(0.002)S(0.026)QFQES(0.967)DDADEDY(0.004)GRDSGPPTKK;VVDYS(0.004)QFQES(0.996)DDADEDYGRDSGPPTKK 98.76 1.8825e-06 19640400.0 60895.0 114702.0 94780.0 104451.0 84512.0 37257.0 22332.3 25809.4 18199.9 85227.0 True False 57510.69968199928 123499.2745749396 88681.95798866144 90224.59361197497 73894.84701313403 42388.81356462754 23370.79620061295 25884.501081023827 21840.388547694212 82766.2750636608 0.6948566869508643 1.4921448921067 1.0714745579700249 1.090113014540977 0.8928134914407687 0.512150794898328 0.2823710041636764 0.3127421290992547 0.2638802885703795 1.0 16.336755409233014 -6.668343121203149 2.2786623304271747 0.40294635081920926 1.1146171110283372 0.5368961365865442 0.26854386750979903 0.20260449301685787 2.1514730453654254 0.09593251685842899 0.0939320425126402 2.1461342169642078e-07 6.668343121203149 0.7116707602091279 VVDYSQFQESDDADEDYGR ddPTM_A459_Selumetinib_30min_R1 1 VVDYSQFQESDDADEDYGR 19 0 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 0 128.06 0.0088434 0.0 168.87 345.7 202.68 285.56 352.81 189.9 364.17 274.76 59.922 257.88 False True 172.8043424361801 305.2252832884301 175.15716924154816 235.6923066250843 320.89839779366446 187.9897784154044 336.7003637050511 267.47247225373854 101.68325747027893 290.9814099639164 0.5938672936446661 1.0489511454572993 0.6019531256765468 0.8099909429070115 1.1028140864169225 0.6460542563138875 1.1571198440024197 0.9192081112223178 0.3494493255871168 1.0 8.184783175865084 -4.721686942461125 23.35397957092795 0.8482425496525803 0.5938615178074487 0.09129211915962732 0.24090635313748873 8925.151180986231 5242611.157739859 0.05765986064414744 16.670091511901813 1.8980736386789628e-05 4.721686942461125 -0.2543810318451316 VVEHNIR ddPTM_A459_Selumetinib_30min_R1 1 VVEHNIR 7 0 O00232-2;O00232 O00232-2 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 100.45 0.028886 1817900.0 1254.6 1784.0 1402.0 1278.1 1394.0 1501.4 1374.7 1281.6 871.47 1124.6 False True 1283.8297389733611 1575.1284506409008 1211.616100634747 1054.903827908391 1267.912946130689 1486.2972791621285 1271.00527222268 1247.6078047765 1478.8209403495205 1268.9533645316446 1.0117233421318106 1.2412815905352532 0.954815310397116 0.8313180431951833 0.9991800972123671 1.1712780947711998 1.0016170079597786 0.9831786097489698 1.1653863583042987 1.0 10.309423334144311 VVESPDFS(ph)KDEDYLGK ddPTM_A459_Selumetinib_30min_R1 1 VVESPDFSKDEDYLGK 16 1 Q9Y6Y8 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 VVES(0.398)PDFS(0.601)KDEDY(0.001)LGK 58.32 0.044435 10200000.0 2776.0 3677.4 3284.5 3215.1 2938.5 2991.5 3324.9 3321.3 2112.8 3484.8 True False 2840.6753988442924 3246.84829842312 2838.482940467066 2653.6431399016265 2672.7131938343127 2961.408226064679 3074.1001161076547 3233.2083348971523 3585.26728719344 3932.108024826494 0.7224306608335458 0.8257271361628954 0.7218730824650513 0.674865268997466 0.679715098608525 0.753135012407334 0.7817944208802099 0.8222582682071201 0.9117926731811092 1.0 11.941087241320414 -8.214158146444248 1.0774567376480757 0.9983774444384392 0.7285919499587261 0.8392846789659922 0.03954407902089609 0.20010546731209536 0.4622450808130504 0.04135675007377848 0.014041523493403903 6.1071959352899975e-09 8.214158146444248 -0.2697854944797131 VVFPPGS(ph)PIPLR ddPTM_A459_Selumetinib_30min_R2 2 VVFPPGSPIPLR 12 0 A0A1B0GTU4;A0A1B0GV30 A0A1B0GTU4 1 VVFPPGS(1)PIPLR;VVFPPGS(1)PIPLR 105.66 0.0092291 2510300.0 23953.4 23413.5 22683.3 26915.0 29489.0 21243.1 24076.0 23212.6 22097.0 24069.0 True False 22622.165921057604 25209.24016373167 21223.881173709677 23249.13056903525 25784.328184995124 24169.1441993381 25195.581705688935 23280.144822947193 26517.01744176611 23374.06543122774 0.9678318899045436 1.0785132880672155 0.9080098297900109 0.9946549793590644 1.1031169678573447 1.0340154249353704 1.077928945643647 0.9959818454108087 1.1344632160710644 1.0 14.512621062210158 -6.136172848986444 7.790323716363821 1.0570958171963887 0.9872723022125961 0.27725566230399756 0.05573175141183229 0.37447738204783454 22.0824597220884 0.0156826270258486 0.02030392776451033 7.308481483939582e-07 6.136172848986444 -0.06982351498379258 VVFPPGS(ph)PIPLRR ddPTM_A459_Selumetinib_30min_R1 2 VVFPPGSPIPLRR 13 1 A0A1B0GTU4;A0A1B0GV30 A0A1B0GTU4 1 VVFPPGS(1)PIPLRR;VVFPPGS(1)PIPLRR 104.16 0.0040563000000000005 26372000.0 2714.1000000000004 2373.73 2894.6000000000004 3418.8 2885.2 2458.8199999999997 2297.3 2210.77 1705.49 1931.13 True False 2777.3332492807262 2095.8125880828625 2501.5292188996727 2821.7707588241983 2624.234169423433 2434.0865032299353 2124.0128114331583 2152.1331980069795 2894.0919659388214 2179.009346299124 1.2745852852801243 0.9618189989145459 1.1480121566014958 1.2949787313288739 1.2043244210404551 1.1170610660133422 0.9747607622888939 0.9876658866389024 1.3281686794295806 1.0 11.089456669197816 -6.998755170861057 18.647625092342125 1.0679480775007448 1.1688681737139075 0.1303288284410189 0.12613574788042992 3.8073418603662463 56974.10389818159 0.04561893520586728 0.039623845283008115 1.0028704368558933e-07 6.998755170861057 0.10092009621316267 VVFPPGS(ph)PIPLRR ddPTM_A459_Selumetinib_30min_R2 2 VVFPPGSPIPLRR 13 1 A0A1B0GTU4;A0A1B0GV30 A0A1B0GTU4 1 VVFPPGS(1)PIPLRR;VVFPPGS(1)PIPLRR 69.729 0.032347 10123500.0 17376.9 15999.7 15050.9 15417.099999999999 14225.400000000001 13641.7 10854.3 12319.4 10565.0 15004.6 True False 16411.1614632422 17226.825542855942 14082.541480180887 13317.264384019083 12438.278075310447 15520.720347977021 11359.04645738741 12355.247414413541 12678.295210764312 14571.378211367322 1.1262600712978295 1.1822372113996102 0.9664522652493442 0.9139330673353953 0.8536102690414819 1.065151156111582 0.7795450981106283 0.8479120667374519 0.8700820901672711 1.0 13.830849718494084 -5.397634873766452 3.1257083778101764 0.898441388392564 1.156370000225968 0.6146014247000275 0.07763320629224112 0.15953547936904028 2.910234277446988 0.021154719121005614 0.050912313341043805 4.002811383862026e-06 5.397634873766452 0.257928611833404 VVGQT(ph)TPESFEK ddPTM_A459_Selumetinib_30min_R2 2 VVGQTTPESFEK 12 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 VVGQT(0.91)T(0.087)PES(0.003)FEK;VVGQT(0.911)T(0.082)PES(0.007)FEK 172.33 0.00053561 34537000.0 188824.0 170783.0 200311.0 209940.0 210605.0 152384.0 187494.0 183250.0 150799.0 180517.0 True False 178329.91800236198 183881.50694610324 187423.20834212622 181345.80983329972 184146.91706741147 173373.51279577546 196212.8425123129 183783.2271613295 180963.01367610478 175305.00517050692 1.0172551424239882 1.0489233137824818 1.0691263957913397 1.0344588259583194 1.050437304333123 0.9889821036606865 1.1192654900039527 1.0483626921123923 1.0322752251146208 1.0 17.41950766181541 VVGQTT(ph)PESFEK ddPTM_A459_Selumetinib_30min_R1 3 VVGQTTPESFEK 12 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 VVGQT(0.029)T(0.873)PES(0.098)FEK;VVGQT(0.127)T(0.437)PES(0.437)FEK;VVGQT(0.079)T(0.918)PES(0.002)FEK 203.74 0.00010082 79565200.0 14603.7 16294.4 14913.7 15819.3 15559.5 13226.099999999999 15225.3 14872.900000000001 7505.700000000001 12474.099999999999 True False 14943.937796146403 14386.644072938952 12888.50145509017 13056.756220038495 14152.145972252843 13093.057442337966 14076.84336304065 14478.42237801218 12736.624705361512 14075.27224302346 1.0617157194635085 1.0221219046096834 0.9156839905159544 0.9276379166669545 1.0054616157969865 0.9302169944760863 1.0001116227089653 1.0286424395939158 0.9048936663853545 1.0 13.780875206640847 -5.039543748466026 5.888994091637272 0.9653342417088785 1.0533043968155655 0.3806442452451999 0.04109496641531984 0.1706804391422306 16.651525482540656 0.010444940758306135 0.030953034165018888 9.129694630784904e-06 5.039543748466026 0.08797015510668704 VVGQTTPES(ph)FEK ddPTM_A459_Selumetinib_30min_R2 1 VVGQTTPESFEK 12 0 Q02952-3;Q02952-2;Q02952 Q02952-3 AKAP12 A-kinase anchor protein 12 1 VVGQT(0.193)T(0.193)PES(0.613)FEK 182.37 0.0001042 13965000.0 128300.0 123280.0 137760.0 142630.0 149080.0 108500.0 137720.0 120440.0 112830.0 128250.0 True False 121169.59962559336 132735.17959232224 128896.67158174737 123203.5479495261 130351.23760789029 123444.89013506439 144124.2528870027 120790.4604600847 135399.15273360477 124547.08926648195 0.9728818259761808 1.0657429280287793 1.0349231952419138 0.9892125835708516 1.046602039241477 0.9911503421082825 1.1571868418268152 0.9698376828513467 1.0871322126517438 1.0 16.92633177983827 VVGS(ph)SPGHPAVQVESHSGGQK ddPTM_A459_Selumetinib_30min_R2 1 VVGSSPGHPAVQVESHSGGQK 21 0 Q6AI39 Q6AI39 GLTSCR1L GLTSCR1-like protein 1 VVGS(0.5)S(0.5)PGHPAVQVESHSGGQK 78.531 0.0012407 5186500.0 23415.0 26776.0 22458.0 32533.0 34961.0 21732.0 23173.0 23926.0 17530.0 28497.0 True False 22113.688037671633 28829.63310159009 21013.076730421595 28101.949277444688 30568.886624694438 24725.38573654578 24250.590416428393 23995.620698837483 21036.48982912432 27674.217565902083 0.799071843133817 1.0417506125669698 0.7593015658123682 1.0154559640403211 1.1045980451624016 0.8934447984903605 0.8762882043071019 0.8670749459020997 0.7601475914912141 1.0 14.756254907766747 -11.014833140569701 7.687357857178605 1.000011299179694 0.9090974955588702 0.06063864619043924 0.112670904871012 2.2015714249515362e-05 1.4549418957799313e-06 0.11007575082150371 0.026693973902732822 9.664221148128364e-12 11.014833140569701 -0.09091380362082369 VVIGMDVAASEFFR ddPTM_A459_Selumetinib_30min_R1 1 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 0 147.62 0.006579300000000001 628550.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 65.961 False True 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 74.42773686454898 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 6.217768463259507 VVITQS(ph)PGK ddPTM_A459_Selumetinib_30min_R2 1 VVITQSPGK 9 0 B3KY49;H0YAP3;B7Z4G6;Q9H7F4;Q8NFB2 B3KY49 FAM11A;TMEM185A;TMEM185B Transmembrane protein 185B;Transmembrane protein 185A 1 VVIT(0.042)QS(0.958)PGK 82.417 0.041393 4439300.0 64199.0 34825.0 44891.0 49337.0 40637.0 37118.0 71281.0 56259.0 52509.0 46370.0 True False 60631.07658895924 37495.96551997587 42002.7619336252 42617.21548892783 35531.81676061065 42230.667576343934 74595.70774062198 56422.70437582115 63012.26722404383 45031.17761627118 1.3464244063440018 0.8326667767717315 0.9327484679958332 0.9463935376526527 0.7890492463553048 0.9378095313475583 1.6565346875065554 1.252969772556733 1.3993031175199717 1.0 15.458636585831021 -7.227374104559098 24.497657086458375 1.3482827172848866 0.948005994559689 0.4236907401256049 0.20631402690427642 414.4503261303825 298047.5028498632 0.0752368560478067 0.05827458494552699 5.924147941294092e-08 7.227374104559098 -0.40027672272519754 VVKPKS(ph)PEPEATLTFPFLDK ddPTM_A459_Selumetinib_30min_R1 3 VVKPKSPEPEATLTFPFLDK 20 2 Q9UPQ0-8;Q9UPQ0-10;Q9UPQ0-6;Q9UPQ0;Q9UPQ0-2;H0Y8P3;G5EA03;Q9UPQ0-5;Q9UPQ0-3;Q9UPQ0-9;E7EPK0;Q9UPQ0-4;E9PDJ9 Q9UPQ0-8 LIMCH1 LIM and calponin homology domains-containing protein 1 1 VVKPKS(0.993)PEPEAT(0.006)LT(0.001)FPFLDK;VVKPKS(0.995)PEPEAT(0.004)LT(0.002)FPFLDK;VVKPKS(0.954)PEPEAT(0.018)LT(0.028)FPFLDK 69.122 0.013991 152680000.0 13481.300000000001 14571.0 21171.6 21970.8 14420.499999999998 17381.3 13431.3 12956.800000000001 9152.050000000001 9808.77 True False 13795.388059956615 12865.020546125883 18296.613007274333 18134.012222994817 13116.168321146064 17206.459902957697 12418.166227398337 12613.14357438215 15530.360410715044 11067.821175010726 1.2464411777002935 1.162380593496842 1.653135944099368 1.6384446347884947 1.1850723022847678 1.5546384090309466 1.1220064031605843 1.1396230003119765 1.4031994342102292 1.0 13.434083618887385 -7.276287917888449 24.720398841782178 1.1778424459436463 1.407244215690708 0.278693567315235 0.18915859000204693 1068.359466075789 1778637.0731826008 0.08153959381696983 0.0552408790747673 5.2931241700169676e-08 7.276287917888449 0.2294017697470616 VVLASAS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 VVLASASPR 9 0 O95671;O95671-2 O95671 ASMTL N-acetylserotonin O-methyltransferase-like protein 1 VVLASAS(1)PR 156.16 0.00083589 8486100.0 2418.1 2844.9 3082.3 3788.3 3137.2 2232.1 2623.0 2553.3 1509.1 2171.9 True False 2474.437025196464 2511.817785441871 2663.740589861969 3126.7445201982287 2853.440813917647 2209.647100584645 2425.1449982105855 2485.578189712734 2560.832479696905 2450.684521097526 1.0096921916690855 1.0249453831442028 1.0869373707346985 1.2758657808790226 1.1643444063700816 0.9016448594513774 0.9895786166407486 1.014238335581269 1.0449457927575474 1.0 11.258969061342508 -6.749801531468094 24.999175414409553 0.9909399757757252 1.1151724434249775 0.38427626640017776 0.07734435412630715 267.498724507746 574611.1889681276 0.02878637346316754 0.02855436869023741 1.779092252877728e-07 6.749801531468094 0.12423246764925222 VVLASAS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 VVLASASPR 9 0 O95671;O95671-2 O95671 ASMTL N-acetylserotonin O-methyltransferase-like protein 1 VVLAS(0.003)AS(0.997)PR;VVLASAS(1)PR 136.99 0.0025921 14843500.0 82672.0 71050.0 80913.0 93989.0 89345.0 74284.0 67653.0 74342.0 68712.0 73506.0 True False 78077.42120223732 76499.30653824228 75707.14567141347 81187.53605993144 78120.68234556582 84515.94671698724 70798.9985518763 74558.32291201942 82456.31997369016 71383.69078847597 1.093771144918749 1.0716636488427713 1.0605664239994084 1.1373401285807176 1.0943771817158192 1.1839671749030847 0.9918091621469639 1.0444727932736135 1.1551142713820246 1.0 16.123306875284612 -10.63721706437234 4.730637804580097 0.9999941424057812 1.0906894794932598 0.21384258505201015 0.053135055368045726 3.2946313033328136e-06 6.168384964131044e-07 0.051625010888322 0.012520095527532435 2.3055945433561888e-11 10.63721706437234 0.09069533708747857 VVLDDKDYFLFR ddPTM_A459_Selumetinib_30min_R1 2 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 ; 204.17 0.00010239 107351000.0 7732.0 8300.3 8616.5 9236.0 7845.1 8064.799999999999 8632.400000000001 8030.900000000001 4196.0 6293.200000000001 False True 7912.140556146998 7328.497017295217 7446.426627046573 7623.105981192318 7135.5120901649 7983.675434252521 7981.251118014886 7817.894443960363 7120.305536285347 7100.993520959044 1.1142300767904942 1.0320382627676932 1.048645743031304 1.0735266774560805 1.0048610900860524 1.124304002065089 1.1239625968475684 1.1009578337010644 1.0027196215951053 1.0 12.793805175122223 -5.853571568874829 16.24805867907602 1.0685439746507535 1.0615504181909892 0.0 0.04914820190255544 17.951574203607873 3114.1772383880825 0.01416859145563043 0.0210164018516468 1.400968695487327e-06 5.853571568874829 -0.006993556459764294 VVLGDGVQLPPGDY(ph)STTPGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R2 1 VVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 31 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 VVLGDGVQLPPGDY(0.609)S(0.176)T(0.109)T(0.107)PGGT(0.088)LFS(0.129)T(0.26)T(0.442)PGGT(0.08)R 59.167 0.0024782 3259500.0 7741.7 8515.3 10835.0 7142.7 11959.0 9526.8 6041.5 6890.9 7434.5 7649.3 True False 7311.4473064805625 9168.396128994991 10137.887896256025 6169.851938155234 10456.603505183517 10839.030224320095 6322.4417210051415 6910.951378150089 8921.607737286067 7428.444833731786 0.9842500644657209 1.2342282044503137 1.3647389356949846 0.8305711459468051 1.4076436911399248 1.4591250883497444 0.8511124283101086 0.9303362322579534 1.201006124023966 1.0 12.858844494685476 -7.279773723856741 24.99141962820275 0.9898083953061042 1.2126751745782227 0.2266645131937648 0.19697757349989045 1324.7433041708587 1805741.581642554 0.08376505649644368 0.05659801116102215 5.250809667167334e-08 7.279773723856741 0.2228667792721185 VVLGDGVQLPPGDYST(ph)TPGGT(ph)LFSTTPGGTR ddPTM_A459_Selumetinib_30min_R1 1 VVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 31 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 VVLGDGVQLPPGDY(0.053)S(0.07)T(0.445)T(0.458)PGGT(0.585)LFS(0.125)T(0.119)T(0.114)PGGT(0.03)R 69.42699999999999 0.00087847 50315000.0 6866.5 7651.0 6873.9 7659.6 7631.2 6230.9 6917.9 6240.6 4003.7 5936.3 True False 7026.476090116834 6755.2173631466 5940.462135629945 6321.9946484994225 6940.959307397792 6168.222803204547 6396.077233366754 6075.079015674338 6793.986481321649 6698.281929458649 1.048996767247853 1.008500005566734 0.8868635566837136 0.943823313959907 1.0362297945196757 0.9208664054698962 0.954883252261626 0.9069607818322036 1.0142879253024715 1.0 12.709575384754489 -5.0143663692440015 17.107001010613857 0.9549955048672216 1.038875882586411 0.2970948075933447 0.04525633737837125 10.800546823618395 12873.18953536621 0.011187646378867941 0.03293243439432589 9.674613650293991e-06 5.0143663692440015 0.08388037771918944 VVLGDGVQLPPGDYSTT(ph)PGGTLFST(ph)TPGGTR ddPTM_A459_Selumetinib_30min_R1 1 VVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 31 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 VVLGDGVQLPPGDY(0.004)S(0.051)T(0.227)T(0.719)PGGT(0.038)LFS(0.116)T(0.69)T(0.153)PGGT(0.002)R 114.33 6.8279e-12 29689000.0 3992.7 4698.2 3830.9 4235.6 4206.1 3523.1 4236.2 3797.9 2063.3 3097.2 True False 4085.722141558217 4148.132559866073 3310.684821627427 3495.931972059135 3825.6589976472706 3487.6608127188565 3916.6600234158136 3697.167354682171 3501.269402530401 3494.755789282775 1.1691009008663023 1.1869592068741919 0.9473293761412941 1.0003365564998754 1.0946856456692233 0.9979698219298538 1.1207249546382827 1.0579186580132791 1.001863825011064 1.0 11.770975929418633 -5.240647360610165 24.825823355377235 1.0333615053648333 1.178030098429217 0.5995441361085476 0.048995286109224184 524.5673269318808 626334.7057901584 0.012730203707890367 0.03360407749361375 5.745828238697126e-06 5.240647360610165 0.14466859306438362 VVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R1 2 VVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 31 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 VVLGDGVQLPPGDY(0.022)S(0.174)T(0.086)T(0.72)PGGT(0.016)LFS(0.048)T(0.298)T(0.627)PGGT(0.008)R;VVLGDGVQLPPGDY(0.004)S(0.028)T(0.081)T(0.887)PGGT(0.031)LFS(0.327)T(0.197)T(0.436)PGGT(0.008)R 106.26 1.8665e-10 90427000.0 16746.3 18647.8 17460.5 17824.2 17918.5 14985.8 18143.0 16060.4 9229.5 14760.7 True False 17136.45620737254 16464.50690687297 15089.46000366119 14711.538071672598 16297.774838768126 14835.05645801773 16774.458902986895 15634.42602046856 15661.787403990847 16655.379626393602 1.0288841558565607 0.988539875775743 0.9059811509639254 0.8832904684057384 0.9785291722165982 0.8907065939529096 1.0071495984639456 0.9387012707709678 0.9403440663202766 1.0 14.02370061731276 -10.4771612903848 4.692526926182467 1.0000006268659476 0.9493905055487399 0.08723318162208005 0.04683009139157637 66721375.37985014 21.60736462589044 451.9411398634356 0.01150765986760946 3.3330260624107415e-11 10.4771612903848 -0.05061012131720766 VVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR ddPTM_A459_Selumetinib_30min_R2 3 VVLGDGVQLPPGDYSTTPGGTLFSTTPGGTR 31 0 Q13541 Q13541 EIF4EBP1 Eukaryotic translation initiation factor 4E-binding protein 1 2 VVLGDGVQLPPGDY(0.009)S(0.006)T(0.039)T(0.945)PGGT(0.014)LFS(0.322)T(0.201)T(0.435)PGGT(0.029)R;VVLGDGVQLPPGDY(0.039)S(0.085)T(0.086)T(0.787)PGGT(0.076)LFS(0.192)T(0.192)T(0.512)PGGT(0.031)R;VVLGDGVQLPPGDY(0.005)S(0.021)T(0.162)T(0.81)PGGT(0.016)LFS(0.177)T(0.174)T(0.624)PGGT(0.012)R 95.145 2.22e-07 60731900.0 70039.0 68431.0 83233.0 83596.0 94384.0 67221.0 69020.0 65783.0 60567.0 71931.0 True False 66146.51276833152 73679.43765965453 77877.87939723856 72210.0805888564 82526.6381163343 76480.08257851755 72229.56676053547 65974.41763903807 72682.09238337564 69854.16513081742 0.9469229593461965 1.0547608366898873 1.114863791606341 1.033726198768921 1.1814132766712604 1.0948535772389754 1.034005153812512 0.9444593248732748 1.040483301851254 1.0 16.092058520014888 -7.520280916898813 7.255360021615036 0.9931285081015381 1.0748463468569711 0.24142293100130474 0.060398066478311856 0.17802600713301225 63.24947770348168 0.02807361499708591 0.017159974578774453 3.0179989413700086e-08 7.520280916898813 0.08171783875543304 VVLIGGKPDR ddPTM_A459_Selumetinib_30min_R1 1 VVLIGGKPDR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 131.11 0.0075127 18368000.0 3467.3 3767.7 4103.6 4440.0 3752.5 3542.9 3216.3 3466.0 2262.4 3062.6 False True 3548.081343808652 3326.5759324437886 3546.3536594613047 3664.6373491223358 3413.0870375576847 3507.261642695819 2973.691901542013 3374.0704208453126 3839.127560841744 3455.714542250232 1.026728712811526 0.9626304174642986 1.0262287628514744 1.060457194689484 0.9876646337041514 1.0149164810389752 0.8605143350774731 0.9763741708388459 1.1109504312071585 1.0 11.754768333908562 VVNANQNAS(ph)PNVPGK ddPTM_A459_Selumetinib_30min_R2 1 VVNANQNASPNVPGK 15 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 VVNANQNAS(1)PNVPGK 162.76 0.00010901 4812200.0 28017.0 26503.0 27133.0 30005.0 30637.0 27935.0 26591.0 26371.0 24458.0 29079.0 True False 26459.92730093727 28535.694879423434 25387.29232017673 25918.267238487937 26788.10616174492 31782.792681318173 27827.534189066908 26447.73524404593 29350.283413617948 28239.413713684473 0.9369857168144788 1.0104917605139723 0.8990021031447392 0.9178047214885436 0.9486070225588193 1.1254763644727024 0.9854147281953671 0.9365539777913194 1.0393375624294623 1.0 14.785422516276808 -6.5622313070502125 24.9999931342215 1.0142444724218949 0.941797119665353 0.3392200463092405 0.0521739599551602 201.2688197009095 127861.29434735599 0.017764238837106105 0.017764261604217218 2.740114386881579e-07 6.5622313070502125 -0.0724473527565419 VVNANQNAS(ph)PNVPGKR ddPTM_A459_Selumetinib_30min_R1 1 VVNANQNASPNVPGKR 16 1 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 VVNANQNAS(1)PNVPGKR 93.215 0.01599 0.0 795.72 855.45 1152.5 1207.7 1084.4 1029.6 1001.7 979.32 552.01 805.96 True False 814.258727798408 755.2935163120846 995.996830229348 996.7978663367212 986.3162114663703 1019.243158802003 926.140962526703 953.3452523203198 936.7206527847645 909.4128167152089 0.8953675523724235 0.8305287790425014 1.0952087016179075 1.0960895294363084 1.0845637903245477 1.1207706116167355 1.018394446948654 1.0483085731777946 1.0300279868148232 1.0 9.82879152647338 -5.261990120894678 24.998971979691973 1.066007784225777 0.8629481528195405 0.8033010571295496 0.03928715248031749 18.33594574504217 832344.1841386603 0.01035060817545258 0.023852889710800865 5.4702840627052785e-06 5.261990120894678 -0.2030596314062364 VVNANQNAS(ph)PNVPGKR ddPTM_A459_Selumetinib_30min_R2 2 VVNANQNASPNVPGKR 16 1 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 VVNANQNAS(1)PNVPGKR;VVNANQNAS(1)PNVPGKR 80.98 0.011446 26402000.0 61322.0 53356.0 63776.0 75473.0 74485.0 54825.0 50310.0 55307.0 43233.0 66923.0 True False 57913.968731415756 57448.23363341946 59672.72159405852 65193.447201812975 65127.52839565138 62376.64609820185 52649.51468737374 55467.93421343326 51880.80803094873 64990.75910316399 0.8911108214551735 0.8839446473032914 0.9181724050851013 1.0031187218220863 1.0021044421449254 0.9597771584601344 0.810107704755376 0.8534741704645342 0.7982797669526371 1.0 15.987946978555103 -7.250248459721983 24.57779681694858 0.8532549240496754 0.9446374948738506 0.25400332712732643 0.06373300572021968 720.5496508650581 1582492.6698651386 0.0250329705744337 0.01919835054042649 5.6201970192292744e-08 7.250248459721983 0.09138257082417522 VVNGAAASQPPS(ph)KR ddPTM_A459_Selumetinib_30min_R1 4 VVNGAAASQPPSKR 14 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 VVNGAAASQPPS(1)KR;VVNGAAASQPPS(1)KR;VVNGAAASQPPS(1)KR;VVNGAAAS(0.003)QPPS(0.997)KR 202.01 9.3254e-05 47409500.0 6131.92 6756.8 7434.500000000001 7110.2 6316.499999999999 5977.0 5817.55 5979.400000000001 4026.4 6206.8 True False 6274.781805360698 5965.710714848904 6424.935734785325 5868.537044984151 5745.173690268649 5916.8768066817875 5378.727519763622 5820.8068881715135 6832.506723379244 7003.503239351776 0.895949011646559 0.8518180846020531 0.917388843155586 0.8379430756895496 0.8203285547134844 0.8448453016249959 0.7680052876310887 0.8311278926045403 0.9755841455156722 1.0 12.77386104125765 -8.305208952038518 5.3620524036771595 0.9932999250920225 0.8446769970788299 0.6843633369218045 0.03857936453915377 0.1277751117603506 8.987995676107467 0.0385686101257335 0.010469826344329846 4.952118722649595e-09 8.305208952038518 -0.14862292801319255 VVNGAAASQPPS(ph)KR ddPTM_A459_Selumetinib_30min_R2 3 VVNGAAASQPPSKR 14 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 VVNGAAAS(0.001)QPPS(0.999)KR;VVNGAAASQPPS(1)KR;VVNGAAAS(0.005)QPPS(0.995)KR 128.44 0.00058238 48691700.0 183084.0 157329.0 168035.0 182730.0 166876.0 155294.0 142436.0 171824.0 115272.0 146249.0 True False 172908.92422332132 169395.62840753177 157223.8110426745 157841.85877316786 145911.54498963177 176684.33888142553 149059.55623157974 172323.97939300572 138329.6209687858 142026.41136946375 1.2174420416321061 1.1927051227596708 1.1070040390845097 1.1113556785051917 1.027355008006654 1.244024524578063 1.049519978673686 1.2133234778757218 0.9739711060426556 1.0 17.115799714086783 -1.5228787456541766 0.01909429409329643 0.09301080900573377 2.4164224273123147 0.31400250704818977 0.07769240003043867 4445.5046145040305 6.568669307687492 300.6062713249632 528.1921505372541 0.029999999974176114 1.5228787456541766 2.323411618306581 VVNGGVPWPSPCPS(ph)PSSRPPSR ddPTM_A459_Selumetinib_30min_R1 2 VVNGGVPWPSPCPSPSSRPPSR 22 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 VVNGGVPWPS(0.002)PCPS(0.563)PS(0.192)S(0.192)RPPS(0.052)R;VVNGGVPWPS(0.001)PCPS(0.486)PS(0.432)S(0.077)RPPS(0.003)R 128.52 1.4822e-05 22808400.0 2520.3999999999996 2807.8 3269.1 3063.5 2943.9 2467.3 2520.0 2420.0 1750.6799999999998 2424.7 True False 2579.120416155316 2479.0614706891947 2825.174175880922 2528.5172340171794 2677.62476478776 2442.48120212916 2329.9143711363613 2355.8137387321553 2970.7760953918087 2735.9338635780514 0.9426837579993053 0.9061116219553205 1.032617861670882 0.9241879957984025 0.9786876797109287 0.892741317560537 0.8515974754189788 0.8610638473735709 1.0858362239453518 1.0 11.417817640674933 -8.267759967485448 24.99653684832836 1.042918116790049 0.9251672871268398 0.43642890711343085 0.054164665778409275 551.5769069760591 2181333.3398905643 0.050818589691188264 0.014372190224363911 5.398088899129113e-09 8.267759967485448 -0.11775082966320916 VVNGGVPWPSPCPS(ph)PSSRPPSR ddPTM_A459_Selumetinib_30min_R2 2 VVNGGVPWPSPCPSPSSRPPSR 22 1 Q99700;A0A2R8Y5A6;Q99700-4;Q99700-2;Q99700-5;H0YH87;A0A5F9ZHW5;A0A2R8Y7P6;A0A2R8YDM9;F8VQP2;V9GY86;A0A5F9ZI57;A0A2R8Y7E6;F8WB06 Q99700;F8WB06 ATXN2 Ataxin-2 1 VVNGGVPWPSPCPS(0.451)PS(0.451)S(0.073)RPPS(0.024)R;VVNGGVPWPS(0.001)PCPS(0.444)PS(0.444)S(0.085)RPPS(0.026)R 136.33 8.633999999999999e-06 8869300.0 63814.0 48434.0 62083.0 70359.0 79772.0 59211.0 47374.0 51806.0 48207.0 64840.0 True False 60267.4733476821 52148.73206014392 58088.64737085949 60775.982823955106 69750.3281892717 67366.77778605804 49576.984869800144 51956.74688305504 57849.74701612072 62967.90072544799 0.9571142225379203 0.8281796194464589 0.9225120529924768 0.9651899161915837 1.107712459613294 1.0698590394459868 0.7873374258729892 0.8251306822121375 0.918718050778866 1.0 15.942328949974037 -10.989909561470508 3.453859608055776 1.0009967188068858 0.9309171061699217 0.04277779854980479 0.0974693374235507 160198932.078146 156196229.67878723 1452043.8540396164 0.027151571227770826 1.023506107468479e-11 10.989909561470508 -0.07007961263696405 VVNTDHGS(ph)PEQLQIPVTDSGR ddPTM_A459_Selumetinib_30min_R1 2 VVNTDHGSPEQLQIPVTDSGR 21 0 Q6IQ49-3;Q6IQ49-2;Q6IQ49 Q6IQ49-3 SDE2 Protein SDE2 homolog 1 VVNTDHGS(1)PEQLQIPVTDSGR;VVNTDHGS(1)PEQLQIPVTDSGR 149.44 1.4145e-06 37885000.0 7958.299999999999 9418.0 10312.400000000001 10097.7 9755.8 9158.4 10007.8 8587.6 4996.0 7490.400000000001 True False 8143.712905843852 8315.336181690585 8912.032721958465 8334.326252304636 8873.389612526387 9066.274811161871 9252.903588673997 8359.828951543912 8477.847106597137 8451.865802674572 0.9635402520549716 0.9838462152415172 1.0544456017200692 0.9860930647605951 1.0498734622263435 1.0726950738253405 1.0947764440067111 0.9891104694182986 1.003074031761643 1.0 13.045054145243872 -5.110636059897709 4.522967251036398 1.0335518584726342 0.9676604957590615 0.30513098285012386 0.035101573444125504 0.26352457524418876 8.477312124164639 0.009578168669103042 0.02863617925166906 7.751110711630318e-06 5.110636059897709 -0.06589136271357265 VVNTDHGS(ph)PEQLQIPVTDSGR ddPTM_A459_Selumetinib_30min_R2 2 VVNTDHGSPEQLQIPVTDSGR 21 0 Q6IQ49-3;Q6IQ49-2;Q6IQ49 Q6IQ49-3 SDE2 Protein SDE2 homolog 1 VVNTDHGS(1)PEQLQIPVTDSGR;VVNT(0.242)DHGS(0.758)PEQLQIPVTDSGR 144.74 3.0286e-06 117800000.0 101876.0 90680.0 119375.0 104866.0 98529.0 86600.0 90356.0 70301.0 73772.0 99599.0 True False 96214.1397619404 97634.86441784412 111694.54246567267 90583.06989605984 86150.90615956415 98528.36392347068 94557.73303701746 70505.56427104287 88528.46136190288 96723.31808072004 0.9947357232063244 1.0094242666113187 1.1547840239771185 0.9365173951173192 0.890694280025291 1.0186619512085415 0.9776105174359786 0.7289407111964743 0.915275273001096 1.0 16.561576116449253 -6.435323682978971 0.8883718269371541 0.8920372414405302 1.0433972055910414 0.2301042358047023 0.09102280002144261 0.8260308880266521 1.4233179065046975 0.05129464732585718 0.06831199773491761 3.67008664191634e-07 6.435323682978971 0.15135996415051123 VVPEDGS(ph)PEKR ddPTM_A459_Selumetinib_30min_R1 4 VVPEDGSPEKR 11 1 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 1 VVPEDGS(1)PEKR;VVPEDGS(1)PEKR;VVPEDGS(1)PEKR;VVPEDGS(1)PEKR 193.15 3.6387e-05 482120000.0 24536.300000000003 29224.1 31888.800000000003 33524.3 26251.0 24807.800000000003 25744.7 25240.4 15305.099999999999 23615.2 True False 25107.948050671188 25802.528786084506 27558.476112640037 27669.910334049968 23876.601684990485 24558.2560556802 23802.756551823117 24570.942599626076 25971.636859723756 26646.44095152736 0.9422627245546658 0.9683292726793039 1.0342272787113207 1.0384092338779654 0.8960521867976478 0.9216336283090945 0.8932808923759388 0.9221097348168624 0.9746756389331266 1.0 14.701655230940244 -6.266469526768027 24.997967563769823 0.9280140250826382 0.9965887201598537 0.3446608129043055 0.040716502917655384 452.35882664097744 2248052.4858983443 0.012911058192884841 0.01509592292240197 5.414152361463023e-07 6.266469526768027 0.06857469507721548 VVPEDGS(ph)PEKR ddPTM_A459_Selumetinib_30min_R2 5 VVPEDGSPEKR 11 1 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 1 VVPEDGS(1)PEKR;VVPEDGS(1)PEKR;VVPEDGS(1)PEKR;VVPEDGS(1)PEKR;VVPEDGS(1)PEKR 157.56 0.0010089 217390000.0 273474.0 244244.0 247579.0 241269.0 216820.0 187793.0 215045.0 212518.0 161152.0 211892.0 True False 258275.40988316102 262976.7294317591 231650.03668363378 208407.74598776028 189581.1332046065 213659.78113487654 225045.01860358356 213136.39219575093 193386.90296309427 205774.12739846713 1.2551403480527406 1.2779873386245646 1.1257490900936238 1.0127985895145766 0.9213069475809074 1.0383218912703218 1.0936507006432334 1.0357783793830762 0.939801837130934 1.0 17.65070207367355 -5.491650020428297 2.6081956427856907 1.0087920223341578 1.2684814770299906 0.8307796452518961 0.04701276650884419 0.11592995117615912 1.553135350080576 0.01445329502020464 0.033913454699822876 3.2236655606877956e-06 5.491650020428297 0.2596894546958328 VVPGQFDDADS(ph)SDSENR ddPTM_A459_Selumetinib_30min_R2 2 VVPGQFDDADSSDSENR 17 0 Q9BRS2;E9PFQ8 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 1 VVPGQFDDADS(0.493)S(0.493)DS(0.015)ENR;VVPGQFDDADS(0.5)S(0.5)DSENR 203.92 2.2543e-08 43572000.0 144091.0 109809.0 131675.0 174641.0 167107.0 133158.0 136604.0 170850.0 149659.0 124193.0 True False 136082.99906197487 118230.99720841453 123203.17385689988 150854.5945274709 146113.52470446526 151499.30581202664 142956.3566756909 171347.1452142601 179594.98182184357 120607.225397834 1.1283154770627764 0.9802977957449791 1.0215239878912967 1.2507923470576758 1.2114823487771682 1.2561378915093375 1.1853050777359007 1.4207038147926527 1.489089739270869 1.0 16.879956813958167 -5.790975159705632 5.806032703865812 1.2727493318383736 1.0363187847613928 0.36620962874458884 0.12918236163090988 0.17453877446599556 16.66532023546057 0.03682149369016499 0.057245403347673605 1.6181725894382566e-06 5.790975159705632 -0.23643054707698075 VVPGQFDDADSS(ph)DSENR ddPTM_A459_Selumetinib_30min_R1 3 VVPGQFDDADSSDSENR 17 0 Q9BRS2;E9PFQ8 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 1 VVPGQFDDADS(0.022)S(0.978)DSENR;VVPGQFDDADS(0.447)S(0.553)DSENR;VVPGQFDDADS(0.214)S(0.786)DSENR 319.45 1.5573999999999992e-118 50950000.0 4724.0 5961.7 3724.9 4678.9 4834.3 4342.7 5181.5 4928.9 2804.98 4201.599999999999 True False 4834.060008696124 5263.701392480862 3219.079039411103 3861.8179488307396 4397.038418564987 4299.016380856117 4790.655283350416 4798.169560676417 4759.846192366459 4740.916287049757 1.0196467762784165 1.110270899922688 0.6789993420057447 0.8145720605486425 0.9274659480016336 0.9067901900312543 1.0104914310418274 1.0120764152244268 1.0039928790492274 1.0 12.210950203496393 -7.259291927454642 19.12806894911489 1.0076465944855186 0.9047519239936477 0.16310269663995403 0.10731035885477756 14.838931706399004 132193.34705351153 0.04630190412187985 0.03394506575302803 5.5043757459843604e-08 7.259291927454642 -0.10289467049187095 VVPGQFDDADSS(ph)DSENR ddPTM_A459_Selumetinib_30min_R2 2 VVPGQFDDADSSDSENR 17 0 Q9BRS2;E9PFQ8 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 1 VVPGQFDDADS(0.22)S(0.762)DS(0.019)ENR;VVPGQFDDADS(0.071)S(0.929)DSENR 320.5 1.3507999999999993e-118 39498900.0 109042.0 87012.0 115181.0 114409.0 125100.0 102888.0 112873.0 129892.0 105307.0 88723.0 True False 102981.88216971135 93685.54061232286 107770.37985959089 98826.29683346661 109383.81959181016 117059.88807572819 118121.8181536065 130269.96421522196 126371.34252342263 86161.33645996157 1.195221504224997 1.0873269201883575 1.250797449151347 1.146991224763445 1.2695232465740578 1.3586127245150719 1.3709376270932923 1.5119306357992401 1.4666827107788225 1.0 16.394753007439988 -6.566350319795174 2.161816267368239 1.378989157266673 1.1681917374992699 0.24044277863488706 0.1357008895269299 0.36391758603483904 3.443816071076022 0.047866774826240896 0.0501312539929844 2.7142489606906463e-07 6.566350319795174 -0.21079741976740318 VVPGQFDDADSS(ph)DSENRDLK ddPTM_A459_Selumetinib_30min_R1 3 VVPGQFDDADSSDSENRDLK 20 1 Q9BRS2;E9PFQ8 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 1 VVPGQFDDADS(0.092)S(0.809)DS(0.099)ENRDLK;VVPGQFDDADS(0.222)S(0.778)DSENRDLK;VVPGQFDDADS(0.33)S(0.67)DSENRDLK 140.4 3.7371e-05 109914000.0 7348.2 7597.0 12537.4 13027.3 8727.0 8221.0 7859.200000000001 6862.799999999999 4881.0 5891.5 True False 7519.3987628917985 6707.539708250521 10834.889943008613 10752.326607707524 7937.644390876994 8138.3042040707705 7266.374216521778 6680.776250483901 8282.700505864816 6647.731413069695 1.1311225282219393 1.0089967977742362 1.6298627711863936 1.6174429951498999 1.194038070682471 1.2242227759187971 1.0930607398240861 1.0049708442415768 1.2459439154808072 1.0 12.69864637903567 -6.868659032107777 2.095855797859508 1.090820183684432 1.340101897811246 0.24544142409864722 0.1923302476950869 0.5108078289837471 4.590456895603687 0.0874319669967325 0.07480423357206142 1.353134502433952e-07 6.868659032107777 0.249281714126814 VVPGQFDDADSS(ph)DSENRDLK ddPTM_A459_Selumetinib_30min_R2 3 VVPGQFDDADSSDSENRDLK 20 1 Q9BRS2;E9PFQ8 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 1 VVPGQFDDADS(0.099)S(0.891)DS(0.01)ENRDLK;VVPGQFDDADS(0.202)S(0.798)DSENRDLK;VVPGQFDDADS(0.068)S(0.919)DS(0.013)ENRDLK 125.31 0.00012452 66781300.0 178595.0 200360.0 193005.0 199515.0 194771.0 118890.3 91992.1 103898.2 72857.3 173791.0 True False 168669.40487243052 215726.96774105902 180587.2684279555 172340.7128174278 170302.1257051675 135266.35964631187 96269.914928888 104200.52656072711 87430.79580304965 168773.20226675432 0.9993849888908326 1.2782062841948805 1.0699996563585283 1.0211378969099303 1.0090590414703198 0.8014682297282999 0.5704099562958382 0.6173997125209076 0.5180371920944001 1.0 17.36472632619528 -6.788364105607005 1.8548752603080705 0.6426960667120156 1.1051150882806497 0.6429627219040013 0.1415470780206147 0.19207490200207775 1.3636081868124057 0.05656447109482843 0.05076875043742452 1.627930629128063e-07 6.788364105607005 0.4624190215686341 VVPQQITHT(ph)SPR ddPTM_A459_Selumetinib_30min_R2 1 VVPQQITHTSPR 12 0 H7BXF5;A0A2R8YDB8;Q9H0E3;Q9H0E3-3 H7BXF5 SAP130 Histone deacetylase complex subunit SAP130 1 VVPQQIT(0.313)HT(0.537)S(0.15)PR 122.12 0.0049089 4483900.0 27961.0 26679.0 34450.0 37640.0 32415.0 26929.0 26469.0 32299.0 26177.0 35226.0 True False 26407.03955675148 28725.193513494232 32233.524506323974 32513.367067378327 28342.737906223243 30638.225312876923 27699.86094732849 32392.98474261271 31413.131446490996 34208.93385186043 0.7719340120655456 0.8396985897861308 0.9422545772957779 0.9504349714076258 0.8285185977721385 0.8956205839548749 0.8097259349642681 0.9469159396457204 0.9182727407560706 1.0 15.062085521638249 -14.522878745279515 0.07521544477485473 1.3982897125240825 0.749573748258577 0.3754826688294227 0.05545708729017798 351.06333291767214 1.878075282235563 23.695515705064512 2.52458261396006 3.0000000000056824e-15 14.522878745279515 -0.6487159642655055 VVPQQITHTS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 VVPQQITHTSPR 12 0 H7BXF5;A0A2R8YDB8;Q9H0E3;Q9H0E3-3 H7BXF5 SAP130 Histone deacetylase complex subunit SAP130 1 VVPQQIT(0.158)HT(0.272)S(0.57)PR 133.23 0.0011716 3605900.0 30769.0 28613.0 32710.0 33010.0 35934.0 22471.0 23006.0 27968.0 20250.0 31074.0 True False 29058.982158066112 30807.52509470408 30605.474211955192 28513.981054573793 31419.64966596408 25566.17627857171 24075.82458552416 28049.382249648366 24300.565832274235 30176.812880051988 0.9629572968348554 1.0209005575624925 1.0142049902223627 0.9448970362745832 1.0411851573210256 0.8472126059234015 0.7978252932548482 0.9295011491485261 0.8052727744598179 1.0 14.881152823421138 -6.768361319521645 24.999873135740543 0.8666726009939619 0.9962465417864717 0.49170032593193647 0.0610794330442682 125.2096130472375 452215.0351330392 0.019993064486671423 0.018012916256011924 1.7046635717267686e-07 6.768361319521645 0.12957394079250972 VVPS(ph)PLQFCAATPK ddPTM_A459_Selumetinib_30min_R1 2 VVPSPLQFCAATPK 14 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 VVPS(1)PLQFCAATPK;VVPS(1)PLQFCAATPK 115.26 0.0028232 64146000.0 8597.4 9091.7 10703.099999999999 11146.4 9572.1 8467.7 8849.8 7965.1 4539.200000000001 7291.6 True False 8797.702692371733 8027.239537383342 9249.677807919947 9199.89048384171 8706.305245091515 8382.522626056452 8182.252460985139 7753.839673708883 7702.690869949109 8227.547886198588 1.0692982665138369 0.975653943120616 1.1242326311386097 1.1181813355683035 1.0581895560518126 1.0188360787444128 0.9944946628278601 0.9424241318261625 0.9362073580720316 1.0 13.00624680284917 -7.153520778210208 1.7219978291654494 0.9567995485455447 1.0697322622220822 0.5697793628517116 0.04164379930931991 0.28471593673719164 1.6632299398313646 0.022715069917019107 0.015255752256361615 7.022297457350309e-08 7.153520778210208 0.11293271367653746 VVPS(ph)PLQFCAATPK ddPTM_A459_Selumetinib_30min_R2 1 VVPSPLQFCAATPK 14 0 Q9Y2F5 Q9Y2F5 ICE1 Little elongation complex subunit 1 1 VVPS(1)PLQFCAATPK 136.01 0.0005986 18768000.0 64036.0 71151.0 83426.0 84980.0 94774.0 74650.0 69869.0 74347.0 64644.0 76785.0 True False 60477.13547641855 76608.05291347626 78058.46198736099 73405.57740132313 82867.64282969003 84932.35989476998 73118.04694279697 74563.33746119165 77574.6063042735 74568.01753861095 0.8110331677398261 1.0273580476215423 1.046808867446995 0.9844110092281062 1.1113027483502773 1.138991791632283 0.980555060417649 0.9999372374702482 1.0403200844665845 1.0 16.186269366169036 -4.761227056775152 5.249898349671703 1.0399301142203419 0.7981942351682558 0.6494460286584283 0.04975612115111397 0.10637639012537083 8.459926111575081 0.0131687853348182 0.09434600240826427 1.7328977715193902e-05 4.761227056775152 -0.24173587905208604 VVPSFLPVDQGGS(ph)LVGR ddPTM_A459_Selumetinib_30min_R1 1 VVPSFLPVDQGGSLVGR 17 0 Q14126 Q14126 DSG2 Desmoglein-2 1 VVPSFLPVDQGGS(1)LVGR 112.44 0.0019219 27482000.0 1693.0 1877.8 1928.5 1438.4 1983.3 1737.1 1772.3 1944.3 830.9 1793.2 True False 1732.4436059954571 1657.9463030344643 1666.620292492232 1187.210442112065 1803.910865180055 1719.6263511606048 1638.6139841130837 1892.7308480235242 1409.9766134650838 2023.374687247149 0.8562149249541563 0.8193965820982673 0.8236834744432381 0.5867476990765828 0.8915357479510234 0.8498803321001306 0.8098420892783127 0.9354327006030856 0.6968440508581194 1.0 10.982547786654195 VVPSFLPVDQGGS(ph)LVGR ddPTM_A459_Selumetinib_30min_R2 2 VVPSFLPVDQGGSLVGR 17 0 Q14126 Q14126 DSG2 Desmoglein-2 1 VVPSFLPVDQGGS(1)LVGR;VVPSFLPVDQGGS(1)LVGR 207.16 5.4734e-09 10656700.0 58018.0 19863.6 38209.2 44320.0 27592.8 31338.8 41302.0 37613.7 27103.4 37478.6 True False 54793.59182445577 21387.07424845925 35750.86167103144 38283.53954373557 24126.345781238197 35655.43523469819 43222.6248383604 37723.14963971674 32524.837332269733 36396.495436902755 1.505463401536732 0.5876135598147367 0.9822611007427736 1.051846862841622 0.6628755184153324 0.9796392429186136 1.1875490845895171 1.0364500534155516 0.8936255247062191 1.0 15.151511921753336 -7.003948333554335 24.933727959796546 1.0397508946899807 0.9317209075463682 0.012788400199138517 0.2411722773385924 616.9527982964106 3896076.5401232867 0.08286290517592748 0.07142732337012724 9.909498276018682e-08 7.003948333554335 -0.10802998714361256 VVQGS(ph)PEVPGITVR ddPTM_A459_Selumetinib_30min_R2 1 VVQGSPEVPGITVR 14 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 1 VVQGS(0.952)PEVPGIT(0.048)VR 90.561 0.018092 2561100.0 13323.0 13902.0 16777.0 16956.0 18632.0 14942.0 13502.0 15128.0 11159.0 18071.0 True False 12582.560996194707 14968.238698024537 15697.586085416455 14646.563549268514 16291.281587806616 17000.124870028845 14129.869753705427 15172.019975424782 13391.111808511021 17549.24327590331 0.716985957649336 0.8529278706038155 0.8944879182893688 0.8345980119484447 0.9283181805437737 0.9687098527702072 0.8051555005284478 0.8645398400885655 0.7630592156015195 1.0 14.099121202350577 -4.764564397422192 3.48566195576102 0.8777342902043473 0.6939628381686105 0.342459356150176 0.06821407354883964 0.369123754701579 7.195787698799063 0.016991061236404648 0.18521935230195946 1.719632334313783e-05 4.764564397422192 -0.18377145203573686 VVS(ph)ETNDTK ddPTM_A459_Selumetinib_30min_R1 1 VVSETNDTK 9 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 VVS(0.48)ET(0.48)NDT(0.041)K 124.39 0.005326300000000001 79228000.0 5081.4 5985.6 6076.4 7345.4 5798.5 5506.2 6067.5 6270.7 2964.8 4690.9 True False 5199.786733316783 5284.803169370051 5251.25825527602 6062.663780234952 5274.026698808323 5450.812627229596 5609.823590027729 6104.380665895758 5031.049059575502 5293.022708235361 0.9823851171517717 0.9984470992628615 0.992109526963797 1.1454067202096287 0.9964111226280057 1.0298109280258199 1.0598525453706178 1.1532882064529997 0.9505058521188172 1.0 12.369876128128219 -5.601597541020487 24.999999998445805 1.0531812081224925 0.9915966980647664 0.15563066552915095 0.059868812296394465 51.93597178346464 16490.991507760402 0.01561100539861547 0.02703906134927346 2.502663495795629e-06 5.601597541020487 -0.06158451005772614 VVS(ph)ETNDTK ddPTM_A459_Selumetinib_30min_R2 1 VVSETNDTK 9 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 VVS(0.996)ET(0.004)NDT(0.001)K 113.38 0.0091489 18738000.0 91159.0 89629.0 95224.0 106720.0 89174.0 60621.0 88019.0 81173.0 59554.0 91137.0 True False 86092.74771839031 96503.25609734161 89097.391512052 92184.55189773133 77971.16489432522 68970.99248735244 92112.05790633966 81409.19999108637 71466.4640777905 88505.6380076364 0.972737439743241 1.090362809305043 1.0066860543320928 1.041567000395811 0.8809739882062401 0.779283603168891 1.0407479114312705 0.9198193677114926 0.8074792260310497 1.0 16.433481740582117 -6.258889640770078 24.999999680393593 0.9012381565229515 1.0307934893081552 0.3719360465156174 0.07826408467372385 240.83842648170761 2361400.9568704967 0.023522028213810775 0.028966566117597698 5.509476807701605e-07 6.258889640770078 0.1295553327852037 VVSAPVGKET(ph)PSK ddPTM_A459_Selumetinib_30min_R1 1 VVSAPVGKETPSK 13 1 Q13416 Q13416 ORC2 Origin recognition complex subunit 2 1 VVSAPVGKET(0.5)PS(0.5)K 182.02 0.0012083 7881500.0 938.84 1128.4 770.72 749.02 770.78 808.45 672.33 672.82 598.92 854.21 True False 960.7131453353662 996.2864034210722 666.06045726192 618.2177178467595 701.0630850922614 800.3177270138692 621.6156068040119 654.9746279726323 1016.3234966139224 963.8561742100081 0.9967391100884756 1.0336463365373412 0.6910371848868777 0.6414003814972297 0.7273523829080245 0.8303289935034367 0.6449256885380207 0.6795356459789864 1.054434804494475 1.0 9.912674074575971 -5.254013200970707 24.50120128793533 0.7618067252308833 1.015192767674262 0.3026998122894393 0.1374286873566111 459.2933985679116 1515333.8920025427 0.03421552784280788 0.0866490970947554 5.571688127716304e-06 5.254013200970707 0.2533860424433787 VVSAPVGKETPS(ph)KR ddPTM_A459_Selumetinib_30min_R2 1 VVSAPVGKETPSKR 14 2 Q13416 Q13416 ORC2 Origin recognition complex subunit 2 1 VVSAPVGKET(0.007)PS(0.993)KR 96.23 0.0135 100910000.0 253760.0 213080.0 191100.0 212540.0 227820.0 179610.0 181530.0 168360.0 110760.0 213930.0 True False 239657.03508176605 229422.5508398124 178804.83405394803 183591.68534804942 199199.21486335903 204349.64716275467 189971.50469487096 168849.89972650146 132915.09489297235 207753.2850431071 1.1535655623064596 1.1043028792166107 0.860659478943245 0.8837005167449248 0.9588258246892549 0.9836169238929424 0.9144091495614783 0.8127423818663877 0.6397737338564516 1.0 17.66451176384124 -1.5228787722865702 0.48499467847020067 0.8559499768980611 10.18339230610865 0.45766630963486477 0.10260782428105748 94.87139421036929 1.0495831161593934 0.0616638543271427 894.5390895521729 0.029999998134475597 1.5228787722865702 9.327442329210589 VVSET(ph)NDTK ddPTM_A459_Selumetinib_30min_R1 1 VVSETNDTK 9 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 VVS(0.044)ET(0.956)NDTK 152.69 0.0025254 66299000.0 5034.2 6219.4 6325.4 6794.1 6208.2 5533.0 6530.1 5172.5 3372.1 4926.9 True False 5151.487065151994 5491.229756679381 5466.445422935113 5607.637976052264 5646.669406146735 5477.343043562048 6037.529299586329 5035.308497352099 5722.207411560486 5559.315607070031 0.9266405128358997 0.987752835923893 0.9832946731758113 1.0086921434934868 1.0157130490964774 0.9852549181766664 1.0860202453532468 0.9057425145909097 1.0293006938270062 1.0 12.440691572096501 -3.531933643818058 1.095487649589912 1.002732270354931 1.272326626380042e-07 0.22296153163752985 0.042257266513448986 33.66272366799988 3.7108778713795756 0.012331199132951902 71.36166043654511 0.0002938098531962344 3.531933643818058 -1.0027321431222684 VVSET(ph)NDTK ddPTM_A459_Selumetinib_30min_R2 1 VVSETNDTK 9 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 VVS(0.026)ET(0.948)NDT(0.026)K 101.56 0.039567000000000005 5857600.0 38796.0 35989.0 37858.0 34557.0 28203.0 24158.0 39258.0 52417.0 27727.0 46952.0 True False 36639.87363269307 38749.240577125995 35422.257496673796 29850.27698584995 24659.887001981002 27485.545215510432 41083.57478825121 52569.52479189853 33273.17475710954 45596.373764053584 0.8035699027798242 0.8498316286650496 0.7768656709406864 0.6546633980218566 0.5408300039294331 0.6028011209342917 0.901027239596845 1.1529321402602921 0.7297329153692661 1.0 15.476631472346448 -7.422828167769813 5.698161003426544 0.9690339454136033 0.7061076023946433 0.45707560573932837 0.12971217447509192 0.2155316048256739 10.014059237500579 0.05859817564707989 0.03881965113215911 3.777216100660977e-08 7.422828167769813 -0.26292634301896 VVSETNDT(ph)K ddPTM_A459_Selumetinib_30min_R2 1 VVSETNDTK 9 0 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 VVS(0.306)ET(0.08)NDT(0.614)K 118.03 0.017172 62461000.0 102820.0 83268.0 97077.0 85405.0 90343.0 58776.0 81090.0 78973.0 60942.0 86324.0 True False 97105.6760210718 89654.38785118016 90831.17150944592 73772.69166815755 78993.30466333269 66871.86048459486 84860.84567678669 79202.79835531606 73132.10286175102 83831.60182331216 1.158342127658932 1.0694581267830288 1.0834955975299914 0.8800105218512312 0.9422855217513687 0.7976927439074523 1.0122775162479158 0.9447845040853209 0.8723691456580782 1.0 16.35520657573391 -5.709284061446217 6.423032115226009 0.9186227413807732 1.1028894296623701 0.6399286750184774 0.06273083088757339 0.12395701171745419 11.098275960585406 0.016797462589713534 0.029017655703180854 1.953061587879196e-06 5.709284061446217 0.18426668828159698 VVSISSEHLEPIT(ph)PTK ddPTM_A459_Selumetinib_30min_R2 2 VVSISSEHLEPITPTK 16 0 O00267-2;O00267 O00267-2 SUPT5H Transcription elongation factor SPT5 1 VVSISSEHLEPIT(0.929)PT(0.071)K;VVSISSEHLEPIT(0.942)PT(0.058)K 171.04 1.1720999999999997e-05 36861000.0 148495.0 119018.0 174688.0 240526.0 265620.0 177464.0 161627.0 175699.0 166323.0 206981.0 True False 140242.24237258383 128146.29789681266 163448.7642659137 207765.94386950642 232250.44092707138 201908.05514220335 169142.9757578247 176210.25500146477 199592.24745290657 201004.9207287775 0.6977055181739419 0.6375281631524068 0.8131580245563264 1.0336361075948572 1.1554465437214567 1.0044930960403924 0.841486741441792 0.876646473939964 0.9929719468023517 1.0 17.61687129436892 -5.538775372401765 3.6469554368139008 0.9821969682523074 0.6730175876062257 0.7117178016839236 0.08208328323464488 0.13606685252064554 3.8964901441893667 0.026294906135014957 0.05261509318255778 2.89217539856228e-06 5.538775372401765 -0.30917938064608175 VVSQSQPGS(ph)R ddPTM_A459_Selumetinib_30min_R1 5 VVSQSQPGSR 10 0 Q7Z460-4 Q7Z460-4 CLASP1 CLIP-associating protein 1 1 VVS(0.001)QS(0.055)QPGS(0.945)R;VVSQSQPGS(1)R;VVSQSQPGS(1)R;VVSQSQPGS(1)R;VVSQSQPGS(1)R 118.76 0.005612300000000001 44025700.0 8997.699999999999 10140.199999999999 9206.300000000001 11054.199999999997 11505.800000000001 8636.13 9635.4 8809.4 4038.1399999999994 7264.889999999999 True False 9207.328903523518 8952.980669948915 7956.135026586075 9123.791483033352 10465.102421513979 8549.258373178649 8908.59402049496 8575.746095035973 6852.428645923572 8197.409397521158 1.123199837537424 1.0921719577231601 0.9705669975433894 1.1130091277120215 1.276635326360369 1.0429219718810052 1.0867572410362791 1.0461532026970888 0.8359261217325196 1.0 13.000952335873986 -8.067194768113325 4.780235132355613 0.9193137450069315 1.0987679646344009 0.4407389747002284 0.08115356405091277 0.20981766990473974 9.155775156949204 0.05902680265119925 0.0216832078697815 8.56653575508842e-09 8.067194768113325 0.17945421962746932 VVSQSQPGS(ph)R ddPTM_A459_Selumetinib_30min_R2 4 VVSQSQPGSR 10 0 Q7Z460-4 Q7Z460-4 CLASP1 CLIP-associating protein 1 1 VVSQSQPGS(1)R;VVSQSQPGS(1)R;VVSQSQPGS(1)R;VVSQSQPGS(1)R 112.02 0.0084914 84723600.0 45050.6 46213.299999999996 46381.0 59852.9 53068.0 28805.899999999998 42173.0 45965.7 41265.5 40923.5 True False 42546.868003840675 49757.71151081984 43396.89695581456 51700.83176798853 46401.12340606064 32773.6512510751 44134.128064214136 46099.452576968746 49519.75305440559 39741.93222297764 1.0705787470303547 1.2520204410708389 1.0919674642976651 1.3009138931120365 1.167560830855447 0.8246617468721442 1.1105179239044913 1.1599700869681262 1.2460328495496427 1.0 15.27837439659453 -6.552590963587571 24.999984219746352 1.071458834589163 1.1849318284513108 0.16742927852645706 0.1206328437919373 388.66949759286155 327025.55456174345 0.040822817174916995 0.04082333563128164 2.801618757236044e-07 6.552590963587571 0.11347299386214793 VVSS(ph)TSEEEEAFTEK ddPTM_A459_Selumetinib_30min_R2 1 VVSSTSEEEEAFTEK 15 0 Q8N573-5;Q8N573-8;Q8N573-3;Q8N573-2;Q8N573 Q8N573-5 OXR1 Oxidation resistance protein 1 1 VVS(0.006)S(0.989)T(0.005)SEEEEAFTEK 107.11 0.0043208 3397500.0 22784.0 22030.0 22567.0 24748.0 22083.0 17983.0 21988.0 32702.0 25552.0 44118.0 True False 21517.756491578497 23719.630162385336 21115.063789091804 21377.279707318772 19308.736115475163 20459.995016579363 23010.485568395437 32797.15740589246 30663.113982531926 42844.19870766984 0.5022326742156215 0.5536252486416351 0.4928336723756219 0.49895389229188397 0.4506732929519947 0.4775441164433932 0.5370735423341263 0.7654982096799305 0.7156888191969548 1.0 15.386812249878284 -8.28983746533672 0.9166057335052744 0.9847197316632977 0.4908273568679301 0.9020298572675292 0.051945834170690715 0.15321182496088176 0.2738603927769904 0.049974173385276544 0.017904018004318928 5.130533582302538e-09 8.28983746533672 -0.49389237479536763 VVSSVSSS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 VVSSVSSSPR 10 0 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 VVS(0.002)S(0.072)VS(0.193)S(0.079)S(0.654)PR;VVSS(0.009)VS(0.03)S(0.1)S(0.861)PR 100.82 0.017018000000000002 17324200.0 7451.6 10913.8 11046.0 12226.1 9873.2 9144.1 9809.5 8834.900000000001 4485.6 6974.1 True False 7625.207781710424 9636.007222312033 9546.013871334813 10091.04114732085 8980.170803255032 9052.11865617851 9069.561517326241 8600.569752200305 7611.735584738219 7869.293668486695 0.9689824910520577 1.2245072592601676 1.213071245461673 1.282331245017751 1.1411660539772388 1.1503089143093677 1.1525254869628425 1.092927791809584 0.9672704953457396 1.0 12.942018432884975 -8.017995138449997 2.123633938422927 0.9809880452569166 1.1714081078392375 0.448247003021118 0.07777117663634245 0.297819413639231 2.4561155695002372 0.06577337602950922 0.021902598037357043 9.594113712338963e-09 8.017995138449997 0.19042006258232091 VVSSVSSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 VVSSVSSSPR 10 0 P29375;P29375-2 P29375 KDM5A Lysine-specific demethylase 5A 1 VVSS(0.029)VS(0.12)S(0.056)S(0.795)PR;VVSSVSS(0.001)S(0.999)PR 166.29 0.00033071 52802000.0 388870.0 357680.0 435270.0 412580.0 444240.0 332190.0 331730.0 379210.0 274230.0 406940.0 True False 367258.16216994973 385112.90587752993 407265.2020861425 356385.8922598014 388430.599644011 377946.1571794194 347156.10231052473 380313.43831840483 329083.66262639844 395190.58484290214 0.9293191089457351 0.9744991926632606 1.0305539091930551 0.9018076490903078 0.9828943667734938 0.9563642750488658 0.8784523610260799 0.9623545016124022 0.8327214140418279 1.0 18.592189050503485 -7.078544548160249 8.629433813174279 0.9153652413557376 0.9651638701104299 0.1454349811065302 0.05247896793621765 0.6529824654026852 66.93761181978083 0.018928277039436288 0.014672000909486407 8.345559385353604e-08 7.078544548160249 0.04979862875469232 VVT(ph)DTDETELAR ddPTM_A459_Selumetinib_30min_R2 1 VVTDTDETELAR 12 0 P05198 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 1 VVT(0.999)DT(0.001)DETELAR 102.97 0.026015 3899000.0 12131.0 13521.0 18439.0 22527.0 21004.0 15724.0 14254.0 10918.0 22966.0 16855.0 True False 11456.807584240634 14558.017223132641 17252.654814865247 19458.78373875747 18365.289741857567 17889.838271739634 14916.839243765167 10949.769572427798 27559.841723654812 16368.352355450725 0.6999365199042451 0.8894002833635705 1.054025135835987 1.1888052820586807 1.1219999021918572 1.0929529059033392 0.9113219779141547 0.6689597911045385 1.683727300413183 1.0 13.998621486440705 -4.975069579760323 2.1897338180833046 1.077737347777697 0.673800462397029 0.21142111941873043 0.24150462014679144 0.7057542345580908 5.295567725569894 0.06337110920460975 0.4806978195539782 1.0590840322163272e-05 4.975069579760323 -0.4039368853806681 VVTDTDETELAR ddPTM_A459_Selumetinib_30min_R2 1 VVTDTDETELAR 12 0 P05198 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 132.25 0.026459 6180500.0 20526.0 19593.0 16511.0 20255.0 23198.0 16269.0 16454.0 21961.0 12031.0 15765.0 False True 19385.247092088302 21095.72009857538 15448.70023581756 17496.234058176087 20283.6598472487 18509.907074722214 17219.143602982458 22024.902874160733 14437.536174226741 15309.82348761085 1.2661966421608584 1.3779205302821842 1.009071087483085 1.142810958750409 1.3248787527604626 1.2090215860229194 1.1247120920052855 1.438612462905527 0.9430243389749079 1.0 13.90217002913983 -8.292064947651907 24.81318263177455 0.9715119847247076 1.2289362602440794 0.4351365899209938 0.12057960044293577 693.603603861383 561958.8032948863 0.11546726960757192 0.029829387186583203 5.104286609397189e-09 8.292064947651907 0.25742427551937186 VVTS(ph)ENEAGK ddPTM_A459_Selumetinib_30min_R1 2 VVTSENEAGK 10 0 P49321-4;P49321;P49321-3;E9PPR5 P49321-4 NASP Nuclear autoantigenic sperm protein 1 VVT(0.04)S(0.96)ENEAGK;VVT(0.02)S(0.98)ENEAGK 125.72 0.003578 13550900.0 6603.700000000001 7761.9 7371.900000000001 8318.7 7310.6 7698.799999999999 7488.0 6561.9 3763.2 6121.1 True False 6757.553361436626 6853.133139590588 6370.8364709481375 6865.99520633873 6649.357520791262 7621.357061951105 6923.174131376615 6387.85709594485 6385.875546746665 6906.802809563083 0.9783909498733903 0.9922294480597904 0.9224002257784379 0.9940916797034003 0.9627258377182326 1.1034565879597225 1.0023703184041775 0.9248645534081692 0.9245776552220156 1.0 12.753802319702043 -10.790168685230537 4.208471995050796 1.000015340580178 0.9799253065191633 0.015240285856168656 0.05081160695360569 8.399572085313338e-06 1.4623633166608726e-06 0.052345871358995905 0.012685274405504885 1.6211802890181933e-11 10.790168685230537 -0.020090034061014617 VVVHHVTVS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 1 VVVHHVTVSPLR 12 0 F5H212;P15822 F5H212 HIVEP1 Zinc finger protein 40 1 VVVHHVT(0.063)VS(0.937)PLR 101.45 0.00828 2185300.0 10676.0 8562.2 10557.0 12604.0 13116.0 9069.9 12080.0 9960.7 12133.0 10036.0 True False 10082.67065941415 9218.893208187723 9877.774113592515 10887.313456887252 11468.250821472287 10319.196396645339 12641.7439360659 9989.683987917351 14559.939024344867 9746.234603340466 1.0345195934395395 0.9458928071593926 1.0134964440735876 1.1170789438164854 1.1766852829031644 1.058788015743895 1.2970900507292338 1.024978814330351 1.4939040169784679 1.0 13.250629234978305 -5.962776903792793 1.0356662112433723 1.1911337081197628 0.973528468722253 0.24703090983535658 0.13730698495420676 0.757753549998571 1.6400019628345357 0.05257865904098655 0.11602532928613775 1.0894896182467372e-06 5.962776903792793 -0.21760523939750986 VVVS(ph)PTK ddPTM_A459_Selumetinib_30min_R1 2 VVVSPTK 7 0 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 VVVS(0.999)PT(0.001)K;VVVS(0.991)PT(0.009)K 99.013 0.021486 1023310000.0 20532.6 21455.0 21018.0 20096.8 16177.0 16050.699999999999 17931.300000000003 16387.2 9208.8 14912.9 True False 21010.969630515247 18943.038625841113 18163.871043609917 16587.27114365804 14713.793206281325 15889.244530869568 16578.727604427542 15952.55822287256 15626.661015859037 16827.11597894715 1.2486375952244357 1.125744818633285 1.079440533145146 0.9857465274745127 0.8744096864067581 0.9442642786053785 0.9852388029635992 0.9480268777389559 0.9286594943191672 1.0 14.038500312045615 -5.263116949627686 1.2104884236118716 0.9447254164656667 1.2611868719520503 0.8734794118391428 0.03723630953873916 0.25107495656692935 0.5363122136437547 0.012460406079551543 0.08078241227398648 5.456109156698374e-06 5.263116949627686 0.3164614554863836 VVVS(ph)PTK ddPTM_A459_Selumetinib_30min_R2 5 VVVSPTK 7 0 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 VVVS(0.996)PT(0.004)K;VVVS(0.998)PT(0.002)K;VVVS(0.989)PT(0.011)K;VVVS(0.994)PT(0.006)K;VVVS(0.813)PT(0.187)K 118.33 0.010946 915993500.0 1438422.0 1275889.0 1308847.0 1417472.0 1351046.0 1132026.0 1308072.0 1208973.0 985485.0 1170401.0 True False 1358480.2636994957 1373745.5836702485 1224637.2089848628 1224409.86832441 1181315.522975514 1287952.305991117 1368899.9398954948 1212490.9112737463 1182609.5367515471 1136608.4820629999 1.1952051081246444 1.2086356958878517 1.0774485922910644 1.077248575606304 1.0393337209936782 1.1331538751614985 1.204372447943442 1.0667621528505717 1.0404722078134179 1.0 20.11630395613308 -1.522878745280382 0.07230105139089257 0.902020761739411 1.5996748836192611 0.40636773238267954 0.05557668182192501 295.27377988168286 1.5780620738861144 2.573829165598669 20.860125569973544 0.02999999999999693 1.522878745280382 0.6976541218798501 VVVS(ph)PTKK ddPTM_A459_Selumetinib_30min_R1 1 VVVSPTKK 8 1 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 VVVS(0.912)PT(0.088)KK 99.973 0.032715 2834600000.0 3953.4 4498.4 4445.3 4656.3 3204.4 3722.1 3683.2 3287.3 1829.5 3552.2 True False 4045.506528022704 3971.725236750578 3841.652676285051 3843.1646145761993 2914.5625857827686 3684.6590533964 3405.3732586386686 3200.110125344716 3104.527878606779 4008.1594713580876 1.0093177571729606 0.9909099837798708 0.9584580413372078 0.9588352564410361 0.7271573415703505 0.9192895341930905 0.8496102220914936 0.7983989030906548 0.7745519859654859 1.0 11.968724194382979 -6.082794487269906 8.47980030637977 0.838720954213523 0.982135078322943 0.4558753543137469 0.07224492311495566 0.2928926577196986 27.712183743213544 0.020445297782323776 0.02647123256462012 8.264289319497695e-07 6.082794487269906 0.14341412410942 VVVS(ph)PTKK ddPTM_A459_Selumetinib_30min_R2 1 VVVSPTKK 8 1 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 VVVS(0.774)PT(0.226)KK 95.483 0.039238 1688900000.0 5011800.0 4362400.0 4390900.0 4515800.0 4362900.0 3897900.0 5003400.0 4356000.0 2807100.0 4202700.0 True False 4733264.219825011 4696982.052673172 4108394.2744504497 3900740.249810485 3814793.49717913 4434800.3433867935 5236068.014049017 4368675.238825379 3368598.4369272566 4081357.131074028 1.1597280188463759 1.1508382878116672 1.0066245473032904 0.9557458768093611 0.9346875009135134 1.0865994327283375 1.2829232644659845 1.0703976884462796 0.8253623313872546 1.0 21.9606175256165 -5.2528573935565355 22.019273431398812 1.0291919884811345 1.1552832844373233 0.1838153749068322 0.11253711478759486 241.8367149428852 620470.5030358561 0.031277484922946824 0.0794215515607571 5.586536060595024e-06 5.2528573935565355 0.12609129595618884 VVYAFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 VVYAFSPK 8 0 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 1 VVY(0.001)AFS(0.999)PK 82.26100000000002 0.041744 12988000.0 185530.0 146310.0 163500.0 163480.0 132960.0 112050.0 143810.0 122400.0 96100.0 132720.0 True False 175218.98533543534 157531.5065392007 152980.5880053398 141213.74198127023 116256.37612251878 127483.87041137277 150497.44995410883 122756.16373558903 115322.68525834866 128888.02875202722 1.3594667172119304 1.2222353624655227 1.1869262761374466 1.095631171867458 0.9019951445311419 0.9891055953431023 1.1676604213076827 0.952424867725803 0.8947509429306467 1.0 16.975758745412357 -5.498202035490751 1.1722857296777718 0.9897841084750363 1.3434093688380442 0.7238426653587161 0.07697297621089036 0.3637914985468833 0.8596481789660323 0.027994209708275316 0.11634930469386731 3.1753965201206702e-06 5.498202035490751 0.3536252603630079 VWDIRDS(ph)AK ddPTM_A459_Selumetinib_30min_R1 2 VWDIRDSAK 9 1 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;Q7Z4S6-3;H0YHT2;H0YI78;O75037-3;O75037-4;O75037-2;O75037 A0A1B0GV47;O75037-3 KIF21A;KIF21B Kinesin-like protein KIF21A;Kinesin-like protein KIF21B 1 VWDIRDS(1)AK;VWDIRDS(1)AK 132.88 0.015466 8293600.0 7565.7 8540.2 9160.9 10194.8 9202.0 8363.0 8383.2 8039.299999999999 4748.6 6629.799999999999 True False 7741.966089710473 7540.3094137687385 7916.900097221717 8414.469560097377 8369.68072474505 8278.875812996452 7750.848474646958 7826.071648673316 8058.027375978221 7480.799409720692 1.0349116004434522 1.0079550327162519 1.0582960006833424 1.124808873923749 1.1188217015776856 1.1066833047600133 1.0360989581641982 1.0461544575709343 1.0771612677526774 1.0 12.868976731621997 -5.453637623713974 5.575385736619272 1.0775993329768678 1.0229776893697597 0.2204758774998422 0.0372772023974371 0.3056260593303003 17.74381949172889 0.010342191338197974 0.02170276809894876 3.5185390576234836e-06 5.453637623713974 -0.054621643607108084 VWDMLDYICLQS(ph)FCGK ddPTM_A459_Selumetinib_30min_R1 1 VWDMLDYICLQSFCGK 16 0 A0A096LNH2 A0A096LNH2 EFCAB8 1 VWDMLDY(0.499)ICLQS(0.501)FCGK 52.52 0.032843000000000004 5067400.0 279.44 213.6 323.09 356.05 748.86 267.16 415.54 345.22 0.0 221.59 True False 285.9504083044127 188.591612700054 279.2161526063342 293.8725513862629 681.1257452219713 264.4726129618717 384.1954832468267 336.06364416740297 0.0 250.033234969382 1.1436495965803464 0.7542661787467898 1.1167161543165485 1.1753339567927812 2.7241408339390527 1.0577498347140046 1.5365776605413022 1.3440758953846912 0.0 1.0 7.96597606361688 -5.714636689778563 3.5506418699471576 1.343372873362488 0.9575506846010058 0.026936529533157394 0.6365790390006094 0.7456387405507202 19.222781151618552 0.18461549186397824 0.3263538373206411 1.9291380640101702e-06 5.714636689778563 -0.3858221887614821 VWEDRPSS(ph)AGSTPFPYNPLIMR ddPTM_A459_Selumetinib_30min_R1 1 VWEDRPSSAGSTPFPYNPLIMR 22 1 C9J0Q5;C9JE98;Q9Y618;Q9Y618-4;Q9Y618-5 C9J0Q5;Q9Y618 NCOR2 Nuclear receptor corepressor 2 1 VWEDRPS(0.258)S(0.734)AGS(0.006)T(0.002)PFPYNPLIMR 86.51899999999998 0.00031832 24599000.0 646.24 719.71 878.75 844.7 807.59 529.54 585.97 533.16 352.06 637.92 True False 661.2961346358561 635.4460186158987 759.420576628234 697.1890019828005 734.5436270915953 524.2133083838506 541.7698111328466 519.0188648522467 597.4201065549614 719.8032458669987 0.91871791136386 0.8828051585826175 1.0550391110191737 0.9685827425563225 1.020478347811341 0.7282730543295047 0.752663751162011 0.7210565773805195 0.8299769554878464 1.0 9.491458797713475 -6.760317416154054 24.999756079452574 0.7856019501937765 0.9690720560351712 0.45572851701344796 0.08745515355857061 24.376538885378043 543165.2514224831 0.028905371153537595 0.02737139701478162 1.7365311729066997e-07 6.760317416154054 0.18347010584139467 VWS(ph)PLVTEEGK ddPTM_A459_Selumetinib_30min_R1 2 VWSPLVTEEGK 11 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 VWS(1)PLVTEEGK;VWS(1)PLVTEEGK 115.57 0.0061379 29674000.0 8724.7 12324.2 9520.8 9516.7 8645.400000000001 8323.6 11102.0 9858.5 4827.4 8654.1 True False 8927.968534689056 10881.27693463486 8227.927654010906 7854.7869955839005 7863.425096469342 8239.872141224121 10264.567201728525 9597.02055507891 8191.7452206539265 9764.938033072478 0.9142882939401435 1.1143211454882251 0.8425990647502387 0.8043867732678729 0.8052713770263592 0.8438222662874898 1.0511656261375006 0.982804040596586 0.8388937229206813 1.0 13.253395173662767 -9.409665119257866 14.100980653807492 0.9999934488365695 0.9128537419058259 0.06456809472137848 0.10155027893140721 0.0 0.0 0.10597207590119252 0.02570200366509345 3.893452500509976e-10 9.409665119257866 -0.08713970693074358 VWS(ph)PLVTEEGK ddPTM_A459_Selumetinib_30min_R2 4 VWSPLVTEEGK 11 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 VWS(1)PLVTEEGK;VWS(0.988)PLVT(0.012)EEGK;VWS(1)PLVTEEGK;VWS(1)PLVTEEGK 121.21 0.0045076 50511600.0 224608.0 210789.0 227394.0 236712.0 221174.0 172973.0 235126.0 226016.0 169621.0 216818.0 True False 212125.18653706368 226955.83850653828 212763.71760786755 204471.41724902386 193388.14479935286 196798.46065744234 246059.82489333014 226673.66914103698 203549.93960672533 210557.90097918277 1.0074434896557782 1.0778785191678784 1.010476057267036 0.9710935391079879 0.9184558921798549 0.9346524625399795 1.1686088422664194 1.0765384157369973 0.9667171768911664 1.0 17.68385748667913 -7.224806905593591 24.997513960442074 1.0593444832267478 0.9880865500792907 0.2008970095165259 0.06423932392404962 964.7764354642342 658350.910500449 0.026386294452099477 0.020438096894624672 5.95927043513413e-08 7.224806905593591 -0.0712579331474571 VWS(ph)PLVTEEGKR ddPTM_A459_Selumetinib_30min_R1 1 VWSPLVTEEGKR 12 1 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 VWS(1)PLVTEEGKR 91.712 0.011635 55300000.0 3147.7 4083.0 3192.4 3904.5 3173.5 3037.0 3704.4 4005.8 1968.0 3112.0 True False 3221.0352856419945 3604.960461864795 2758.889614597978 3222.6523715423773 2886.457485326933 3006.450537375371 3424.974125570448 3899.5531713277996 3339.5522629670068 3511.4555134469842 0.9172934907781584 1.0266285442204057 0.7856826333219703 0.9177540080463368 0.8220116912412402 0.8561835756888515 0.9753716407497236 1.110523301917 0.9510450154297326 1.0 11.777853442477062 -7.455082335989076 4.990425029843192 1.0268925788855867 0.8885785712713943 0.42159373749291873 0.07101329971765771 0.20289530493144933 9.731625096189733 0.0313557385598179 0.020316354560907617 3.5068538274379356e-08 7.455082335989076 -0.13831400761419244 VWS(ph)PLVTEEGKR ddPTM_A459_Selumetinib_30min_R2 3 VWSPLVTEEGKR 12 1 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 1 VWS(1)PLVTEEGKR;VWS(1)PLVTEEGKR;VWS(1)PLVTEEGKR 106.55 0.0045457 77715000.0 128138.0 123935.0 155210.0 154058.0 144899.0 117719.0 146716.0 156279.0 127004.0 140933.0 True False 121016.6029370561 133440.41598616552 145223.9575798705 133075.03463512668 126695.49220650432 133933.7237033147 153538.58471223855 156733.74601661888 152408.3487882544 136863.8981020904 0.8842112829987249 0.9749862296529709 1.061083014540066 0.972316560323764 0.9257042504517795 0.9785905966481386 1.1218340763442969 1.1451796141280957 1.113575975123615 1.0 17.06238241776142 -7.241792138421878 8.183714749856609 1.1072978628135155 0.9691508951568222 0.5599645948699363 0.05557075209385453 0.16301944779374716 58.81638506130674 0.022004989530562437 0.016588922664831123 5.730702476502959e-08 7.241792138421878 -0.13814696765669332 VYEDSGIPLPAES(ph)PK ddPTM_A459_Selumetinib_30min_R1 8 VYEDSGIPLPAESPK 15 0 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK 219.53 2.4228000000000004e-09 950959000.0 32775.0 43568.8 38567.799999999996 40164.7 26563.0 36940.700000000004 33215.7 32106.600000000002 25640.2 38022.899999999994 True False 33538.593730951616 38467.744641414385 33330.50459776089 33150.689129795916 24160.381340078562 36569.110097471974 30710.213006886497 31255.028671065233 43509.54671388549 42903.50958940976 0.7817214501079005 0.8966106738016069 0.7768712843479859 0.7726801244711874 0.5631329830891567 0.8523570786502426 0.7157972226697967 0.7284958496444351 1.0141255839038705 1.0 15.388808047324128 -8.265122671481704 24.84055996251408 1.0070628395779566 0.7613483098766127 0.5809302549874336 0.08360993587814072 220.44312865545643 1486657.6285537402 0.07276952435540461 0.021661247659919874 5.4309690584472636e-09 8.265122671481704 -0.2457145297013439 VYEDSGIPLPAES(ph)PK ddPTM_A459_Selumetinib_30min_R2 6 VYEDSGIPLPAESPK 15 0 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK;VYEDSGIPLPAES(1)PK 269.87 6.7221e-45 242545200.0 592259.0 576083.0 497592.0 466963.0 422423.0 339301.0 486570.0 433037.0 303743.4 434023.0 True False 559343.6157806253 620266.713701199 465577.4724572068 403361.83384389506 369354.44623046555 386036.632882188 509196.469120164 434297.0659768658 364500.5672996934 421491.6282628186 1.3270574746311445 1.4715991305868485 1.1045948276033106 0.9569865847783368 0.876303161115591 0.9158820887457275 1.2080820471306195 1.0303812385712734 0.8647872053876506 1.0 18.685144450838663 -5.415311850069052 3.7513734208477216 0.9846706854278553 1.3974059320668752 0.7399051898100196 0.09809134921886174 0.12038622214728453 3.0075267763723814 0.028177552595734023 0.06316580249933437 3.8431572068893455e-06 5.415311850069052 0.41273524663901995 VYEDSGIPLPAES(ph)PKKGPK ddPTM_A459_Selumetinib_30min_R1 2 VYEDSGIPLPAESPKKGPK 19 2 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 VYEDSGIPLPAES(1)PKKGPK;VYEDSGIPLPAES(1)PKKGPK 100.94 0.0011824 107446000.0 7187.0 4335.2 24660.9 25913.0 10460.6 11296.6 6193.299999999999 6606.8 6198.7 4629.1 True False 7354.443116532397 3827.632768620196 21312.085232627258 21387.780997253834 9514.440576968937 11182.966460492133 5726.134394745562 6431.566202089096 10518.741164864628 5223.290076252389 1.408009704452231 0.7328011105533794 4.08020326681115 4.094695237106027 1.8215416793002175 2.140981315844457 1.0962696521066957 1.2313247221957129 2.0138152412189263 1.0 12.350743110897643 -6.91316388032995 2.2197477304840305 1.372614024065449 2.5415529389980893 0.2007353219789939 1.0238836030727378 0.563733543540907 5.649362546070791 0.46910765681730615 0.391435897787296 1.221338702988347e-07 6.91316388032995 1.1689389149326403 VYEDSGIPLPAES(ph)PKKGPK ddPTM_A459_Selumetinib_30min_R2 1 VYEDSGIPLPAESPKKGPK 19 2 H0YIS7;Q8IXM2;Q8IXM2-3;F8W038;F8W1H0;Q8IXM2-2 H0YIS7;Q8IXM2-2 RNASEK-C17orf49;BAP18;C17orf49 Chromatin complexes subunit BAP18 1 VYEDSGIPLPAES(1)PKKGPK 75.018 0.0037331 5355700.0 70113.0 137330.0 94113.0 117490.0 77759.0 34058.0 18502.0 15093.0 10043.0 94419.0 True False 66216.40014457704 147862.76941445182 88057.8720424866 101487.65931844544 67990.21924572001 38749.18035225827 19362.379661017483 15136.918131219343 12051.880624865697 91692.87813997628 0.7221542336526134 1.6125872850095058 0.9603567237584084 1.1068216133811033 0.7414994558457166 0.4225974921749609 0.21116557854645276 0.16508281164554203 0.13143747769011643 1.0 16.484522062430315 -6.543556207978062 1.822743923940082 0.3048812531642509 1.143498622631391 0.5320260512038315 0.3122226582583659 0.23564507232093376 1.5867879128405002 0.11322262462937366 0.12141569901529183 2.8605121187425727e-07 6.543556207978062 0.8386173694671402 VYFQS(ph)PPGAAGEGPGGADDEGPVRR ddPTM_A459_Selumetinib_30min_R1 2 VYFQSPPGAAGEGPGGADDEGPVRR 25 1 Q96C90 Q96C90 PPP1R14B Protein phosphatase 1 regulatory subunit 14B 1 VY(0.01)FQS(0.99)PPGAAGEGPGGADDEGPVRR;VY(0.01)FQS(0.99)PPGAAGEGPGGADDEGPVRR 69.57600000000001 0.00067916 51186000.0 1184.59 1368.25 1416.63 1630.71 1314.06 1328.52 1408.1399999999999 1251.82 659.13 1164.77 True False 1212.1886421891068 1208.0546539178317 1224.2594269915853 1345.9371107178563 1195.2035050161358 1315.1562949996478 1301.922866099982 1218.6176671155736 1118.4954690495138 1314.279575320579 0.9223217532642778 0.919176312713498 0.931506088948361 1.0240873677045126 0.9093982189631166 1.0006670724368938 0.9905981121120422 0.9272134255136153 0.8510331363680292 1.0 10.360056484999493 -5.5401006858752595 24.99939238753721 0.9574023926151823 0.9218970331124278 0.09149205133468274 0.048757569847789305 584.246450794829 848089.9027916498 0.013455820326966213 0.023312083271428648 2.8833629531214937e-06 5.5401006858752595 -0.035505359502754574 VYFQS(ph)PPGAAGEGPGGADDEGPVRR ddPTM_A459_Selumetinib_30min_R2 2 VYFQSPPGAAGEGPGGADDEGPVRR 25 1 Q96C90 Q96C90 PPP1R14B Protein phosphatase 1 regulatory subunit 14B 1 VY(0.002)FQS(0.998)PPGAAGEGPGGADDEGPVRR;VY(0.042)FQS(0.958)PPGAAGEGPGGADDEGPVRR 51.306 0.015504 15712900.0 25123.7 25527.2 29844.0 32453.0 33567.0 24112.1 20858.4 25681.0 22089.2 31567.0 True False 23727.425332139665 27485.054157114962 27923.86953169034 28032.845415452393 29350.013367212556 27433.322907149173 21828.356930135502 25755.727458281573 26507.657223815917 30655.57868908414 0.7740002422654817 0.8965759360106896 0.9108903085764775 0.9144451553098343 0.9574118193914091 0.8948884372852387 0.7120517003291201 0.8401644516158715 0.8646927690604902 1.0 14.903862018382783 -9.252442378230562 15.789300231637235 1.000000021673182 0.8653467725897548 0.26311946043400414 0.06876550958974235 0.0 0.0 0.07198275560840009 0.017458382623320924 5.591877151310289e-10 9.252442378230562 -0.13465324908342713 VYISSPHS(ph)SPAHNK ddPTM_A459_Selumetinib_30min_R2 1 VYISSPHSSPAHNK 14 0 Q9BZH6 Q9BZH6 WDR11 WD repeat-containing protein 11 1 VYISSPHS(0.5)S(0.5)PAHNK 66.059 0.036615 4350500.0 13714.0 13382.0 16918.0 17172.0 19305.0 11959.0 11300.0 12121.0 9462.4 14454.0 True False 12951.830781491723 14408.35637008808 15829.51429892565 14833.143976647716 16879.73331111028 13606.243697006765 11825.472390525218 12156.270103260433 11355.144401546257 14036.675463997912 0.922713559539888 1.0264792690436904 1.127725317830858 1.0567419624890975 1.2025449583417678 0.9693352056122446 0.8424696019264591 0.8660362729365331 0.8089625232606251 1.0 13.776913658528759 -6.999840523998633 7.975468604374909 0.8732168243277874 1.0697193025688758 0.5435214104397545 0.08115951049305457 0.08766647231511564 49.93779468999301 0.029842128763730363 0.025174531637355023 1.0003672744922054e-07 6.999840523998633 0.19650247824108846 VYLDLT(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 VYLDLTPVK 9 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4;Q8N4X5-3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 VYLDLT(1)PVK 104.82 0.03298 13311000.0 3160.9 4414.9 3321.6 3350.4 3441.4 3530.2 4025.7 3635.9 2228.1 3502.4 True False 3234.542819959269 3898.0014555686707 2870.5449642427775 2765.3155347971765 3130.1259776285165 3494.6893931651443 3722.0382078903335 3539.4641209323318 3780.9229660146257 3951.9671562650115 0.8184639932625914 0.9863445978768347 0.7263585072290222 0.6997314060197467 0.7920425079106138 0.8842911023754463 0.9418191145616749 0.8956208341259256 0.9567192277953952 1.0 11.948355241784453 -6.9627959837230184 3.234387321479956 0.9387557168494343 0.8048260856195575 0.44654075972312657 0.07525741373245268 0.2797362569726584 6.044988196686202 0.03184187921903942 0.026558857905903864 1.0894417545732571e-07 6.9627959837230184 -0.13392963122987678 VYLDLT(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 VYLDLTPVK 9 0 Q8N4X5-2;Q8N4X5;Q8N4X5-4;Q8N4X5-3 Q8N4X5-2 AFAP1L2 Actin filament-associated protein 1-like 2 1 VYLDLT(1)PVK 103.21 0.036108 5354300.0 41657.0 38033.0 41025.0 43535.0 45949.0 38995.0 49969.0 40469.0 36849.0 40548.0 True False 39341.87070618349 40950.00880463008 38385.496164642675 37605.457897936096 40176.47583072809 44366.20728863442 52292.6575116951 40586.75808999639 44219.82964708512 39377.273883643815 0.9991009236046928 1.0399401676620263 0.9748134489469293 0.9550040972632268 1.0202960202233868 1.126695753995882 1.3279908016541482 1.0307152854188557 1.1229784412641313 1.0 15.26507561545409 -6.726723169751559 4.4736450357930995 1.1373084565511111 0.9943259215931155 0.34707361455974683 0.08422966373258277 0.21614409559739134 9.70975093975113 0.02920800018119788 0.028118415968496503 1.876190057819294e-07 6.726723169751559 -0.14298253495799562 VYQWDDPDPR ddPTM_A459_Selumetinib_30min_R2 1 VYQWDDPDPR 10 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 136.57 0.025507 8008500.0 51059.0 37693.0 46829.0 51809.0 54688.0 45099.0 39785.0 41425.0 37417.0 45657.0 False True 48221.345185371545 40583.93189790242 43816.07312356009 44752.52482448997 47817.604523076894 51310.97788203933 41635.08133248192 41545.539891722095 44901.445518331144 44338.76377886765 1.0875662981013101 0.9153149172202489 0.9882114292154288 1.0093318128508473 1.0784604812520122 1.157248725696198 0.9390221509135909 0.9370026665362998 1.0126905148341478 1.0 15.436280926142585 VYS(ph)PYNHR ddPTM_A459_Selumetinib_30min_R1 2 VYSPYNHR 8 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 VYS(1)PYNHR;VYS(1)PYNHR 121.6 0.0045069 29818000.0 3786.3 4061.4 3915.2 4461.9 3610.8 3326.5 3992.8 4208.4 2020.67 3406.1000000000004 True False 3874.5134231427064 3585.8893999063653 3383.53734465418 3682.712925236247 3284.203777538516 3293.0384302203393 3691.6198813782757 4096.779561190249 3428.929406102411 3843.3061132235766 1.0081199126480598 0.9330220633658288 0.8803715460011159 0.9582148329442767 0.8545256820003565 0.8568243936880428 0.9605323574608337 1.0659519279753835 0.8921822267304108 1.0 11.908132174006246 -10.555883700402248 4.971348824631234 1.00000103660639 0.9334905185843474 0.08592445134339477 0.0641088792639719 7.718594995269173e-07 1.5023381698058957e-07 0.0650492684491251 0.015776519195104477 2.7804577460746056e-11 10.555883700402248 -0.06651051802204266 VYS(ph)PYNHR ddPTM_A459_Selumetinib_30min_R2 1 VYSPYNHR 8 0 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 VYS(1)PYNHR 92.239 0.017028 32515000.0 161100.0 143010.0 151310.0 140380.0 183410.0 126560.0 148210.0 176740.0 149690.0 209240.0 True False 152146.7069343967 153978.40715037312 141574.8793338714 121260.0018309925 160368.39609379604 143992.49120270734 155102.05867254335 177254.28413911784 179632.18268805565 203198.69752919071 0.7487582783966413 0.757772608893092 0.6967312342813285 0.5967558025984531 0.7892196064433836 0.7086290067485396 0.7633024254511376 0.87231998184267 0.8840223134907171 1.0 17.63253162913449 -8.071025684087784 0.9235549149842401 0.9918908219474769 0.7086591535191977 0.7806056048212948 0.05026318844469443 0.24993914959088523 0.4146988684746289 0.04824425451657623 0.01809861265263162 8.491302561598256e-09 8.071025684087784 -0.2832316684282792 VYS(ph)SMER ddPTM_A459_Selumetinib_30min_R2 1 VYSSMER 7 0 Q6P0Q8;Q6P0Q8-2;A0A669KBJ4;E7ERL6;V9GXZ1 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 1 VYS(0.5)S(0.5)MER 81.548 0.042821 9697000.0 84541.0 64506.0 74253.0 88057.0 87074.0 69043.0 64687.0 87979.0 77811.0 67153.0 True False 79842.5496644371 69453.40278051869 69475.6428205535 76063.48469320219 76134.98566856336 78553.04654004838 67695.07367485881 88235.00432429246 93375.37422099225 65214.11840555219 1.22431386970401 1.0650056226874576 1.0653466537491136 1.1663652986946813 1.1674617020059477 1.2045404961475419 1.0380432233075376 1.3530046327633913 1.4318275935329132 1.0 15.99289671131701 -7.7694279246984905 24.999974436650874 1.2943120978172482 1.1331519345498755 0.18066812245891584 0.1195613840037417 237.81378216069706 744219.2618102654 0.06075103790594572 0.03001187920757901 1.7004821414170016e-08 7.7694279246984905 -0.1611601632673727 VYS(ph)SSEFLAVQPTPTFAER ddPTM_A459_Selumetinib_30min_R1 1 VYSSSEFLAVQPTPTFAER 19 0 O60307;V9GYV0 O60307 MAST3 Microtubule-associated serine/threonine-protein kinase 3 1 VYS(0.498)S(0.492)S(0.01)EFLAVQPTPTFAER 216.77 4.779600000000002e-19 6641200.0 691.8 915.73 1005.9 809.25 1015.5 648.85 828.15 774.65 386.03 843.96 True False 707.9175939915281 808.5159058886728 869.3043050131896 667.9296790038845 923.6482043010866 642.323158108663 765.6819787526098 754.1037655821757 655.064715484326 952.290486866554 0.7433840868461071 0.8490223487888012 0.9128562313728191 0.7013927874063521 0.9699227463043205 0.6745033862746891 0.804042452710027 0.7918841739808847 0.6878832924602357 1.0 9.895257910405208 -6.785458317625336 24.99986392081233 0.7794292576931018 0.8329449554922618 0.03228125326679665 0.10933291975539047 768.2947422498055 799665.6831347854 0.03604396744425501 0.0318042270496387 1.6388593468917363e-07 6.785458317625336 0.05351569779915999 VYSS(ph)SEFLAVQPTPTFAER ddPTM_A459_Selumetinib_30min_R1 1 VYSSSEFLAVQPTPTFAER 19 0 O60307;V9GYV0 O60307 MAST3 Microtubule-associated serine/threonine-protein kinase 3 1 VYS(0.007)S(0.988)S(0.004)EFLAVQPTPTFAER 314.41 3.644199999999999e-117 6450300.0 1393.0 1530.3 1836.7 1587.8 2005.0 1271.7 1334.9 1913.6 1020.7 1447.5 True False 1425.4541896938406 1351.131764582831 1587.286228270927 1310.5205366973967 1823.6481040115016 1258.9078526112146 1234.2074182658437 1862.84511175118 1732.053351021558 1633.3007248439937 0.8727444787180844 0.8272400446720463 0.9718272967903925 0.8023755311947053 1.1165415384149107 0.770775297813855 0.7556522809868527 1.1405401855369355 1.0604619986236745 1.0 10.673574730367468 -7.771919133432751 24.999188744082634 1.0753758435438674 0.8784703449293124 0.41329677964214273 0.10520174679617642 211.12582386293144 503627.25654951826 0.056346348651061834 0.02752163971080534 1.6907557246896832e-08 7.771919133432751 -0.19690549861455497 VYSS(ph)SEFLAVQPTPTFAER ddPTM_A459_Selumetinib_30min_R2 2 VYSSSEFLAVQPTPTFAER 19 0 O60307;V9GYV0 O60307 MAST3 Microtubule-associated serine/threonine-protein kinase 3 1 VYS(0.004)S(0.994)S(0.002)EFLAVQPTPTFAER;VYS(0.021)S(0.489)S(0.489)EFLAVQPTPTFAER 242.09 5.73e-30 4167900.0 14419.6 8575.2 15166.4 14082.8 16290.9 10931.8 10025.5 11000.7 11215.5 13450.3 True False 13618.216358232325 9232.890266386135 14190.610335927777 12164.69834581497 14244.291499506162 12437.55622099996 10491.705615151372 11032.710215736073 13458.913387252924 13061.95489092371 1.042586387103139 0.7068536328204398 1.0864078504656551 0.9313076371338405 1.090517584730293 0.9521971500332144 0.8032262936722961 0.8446446422351614 1.0303904354014457 1.0 13.673083210613157 -10.007522052641963 15.940115381360245 1.0000081522666227 0.9376338127015682 0.017837473652235314 0.1205611735884214 0.0 0.0 0.11494085824294999 0.027877252896166427 9.828289655605348e-11 10.007522052641963 -0.06237433956505445 VYSYFECR ddPTM_A459_Selumetinib_30min_R2 2 VYSYFECR 8 0 A0A0C4DFS8;P43490;C9JF35;C9JG65 A0A0C4DFS8 NAMPT Nicotinamide phosphoribosyltransferase 0 ; 138.83 0.033844 15765000.0 69834.0 56375.0 64084.0 60055.0 65778.0 50907.0 52721.0 58026.0 54928.0 50565.0 False True 65952.90584765152 60698.781225804436 59960.90520938363 51875.405399346535 57514.37957721892 57918.977162264695 55172.63096467963 58194.84605327857 65915.13481655106 49105.05706635223 1.343098038935867 1.2361004110795843 1.2210739339608678 1.0564167623153544 1.1712516594676543 1.1794910875269493 1.1235631167300897 1.1851090199252583 1.342328850722738 1.0 15.583583987161862 -4.905696918565917 1.6600400275166316 1.1609500461367293 1.376949437223494 0.31008857407021406 0.08648126085165847 0.9595711365651569 3.1634666697948113 0.023869850588826277 0.3110366105132382 1.2425191228991633e-05 4.905696918565917 0.2159993910867648 VYT(ph)HEVVTLWYR ddPTM_A459_Selumetinib_30min_R1 2 VYTHEVVTLWYR 12 0 A0A087WZZ9;P06493;E5RIU6 A0A087WZZ9 CDK1 Cyclin-dependent kinase 1 1 VYT(1)HEVVTLWYR;VYT(1)HEVVTLWYR 168.0 0.00055101 229830000.0 12492.900000000001 16891.1 14496.599999999999 16890.4 10877.3 14189.1 11688.0 10455.1 8829.1 9508.9 True False 12783.960263048231 14913.482159540648 12528.041344123882 13940.808712075646 9893.450135543286 14046.370536672015 10806.36474993721 10177.796785049 14982.337848049792 10729.459939529559 1.1914821747877045 1.3899564603989323 1.1676301896582861 1.2993019956871092 0.9220827694312703 1.3091404987610111 1.0071676310682065 0.9485842570278754 1.3963739025532633 1.0 13.3892898403437 -6.2138705780076 24.99872267425738 1.100746740816984 1.2644785671328802 0.21596939309188978 0.15377583544234252 633.6841769140805 333018.22901572223 0.04326705689336604 0.055857368089527105 6.111241159062737e-07 6.2138705780076 0.16373182631589622 VYT(ph)YIQSR ddPTM_A459_Selumetinib_30min_R2 1 VYTYIQSR 8 0 Q92630;A0A0A0MTH5;Q9NR20-5;Q9NR20-2;Q9NR20;Q92630-2;Q9NR20-3;Q9NR20-4 Q92630 DYRK2;DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 2;Dual specificity tyrosine-phosphorylation-regulated kinase 4 1 VY(0.07)T(0.482)Y(0.448)IQSR 107.01 0.031536 8407100.0 80527.0 64073.0 72691.0 75597.0 82270.0 57621.0 64975.0 70821.0 60003.0 79759.0 True False 76051.63171512204 68987.19307283306 68014.14019997674 65300.55818790112 71934.50709686833 65557.76971864088 67996.46624552006 71027.07738495221 72005.2766238988 77456.15043123097 0.981866918142854 0.8906612669071771 0.878098638020524 0.8430648544285437 0.9287126547908549 0.846385591765834 0.8778704578907567 0.9169972557313344 0.9296263269348546 1.0 16.241092180789437 -8.609296127590207 1.4343336008572436 0.9992215481764614 0.8902569649837916 0.41212561127330716 0.038333231495302614 0.5054333747181086 2.2298515995772186 0.036516266200869126 0.01081808006356496 2.458690552236769e-09 8.609296127590207 -0.10896458319266977 VYTDVNTHRPR ddPTM_A459_Selumetinib_30min_R1 1 VYTDVNTHRPR 11 1 P68400;E7EU96;A0A2R8YD58;A0A2R8YFU2;A0A2R8Y5A0;A0A2R8YDP2;Q8NEV1;A0A2R8YF43;A0A2R8Y4H0;A0A2R8Y4D6;A0A2R8Y3W6;A0A2R8YCC9;V9GYA2;A0A2R8YEW1;A0A2R8YDY7;A0A2R8YCK2;A0A2R8YF47;V9GY80;A0A2R8YEL7;A0A2R8Y797;A0A2R8Y7T1 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 107.55 0.008345700000000001 5575200.0 2568.7 2876.1 2636.6 2981.2 2902.6 2510.1 2417.6 2610.3 1585.7 1856.2 False True 2628.545712179875 2539.364874937386 2278.5642018071153 2460.5893840548433 2640.0603424956525 2484.8506729884502 2235.238485579073 2541.0663645506384 2690.8170850542606 2094.461350919115 1.254998432425782 1.212419066039597 1.0878998558780806 1.1748077294312735 1.2604960895254103 1.1863912752068786 1.067214004497233 1.2132314417907684 1.284729882398377 1.0 11.032363547070494 -10.733892565422583 4.7654275159083195 0.9999671298379857 1.1890889057047336 0.42695233733372984 0.06709795155061797 2.4335958608893717e-05 4.02913441896435e-06 0.06747161489104672 0.01636142823504293 1.8454718904899302e-11 10.733892565422583 0.18912177586674783 VYTDVNTHRPR ddPTM_A459_Selumetinib_30min_R2 2 VYTDVNTHRPR 11 1 P68400;E7EU96;A0A2R8YD58;A0A2R8YFU2;A0A2R8Y5A0;A0A2R8YDP2;Q8NEV1;A0A2R8YF43;A0A2R8Y4H0;A0A2R8Y4D6;A0A2R8Y3W6;A0A2R8YCC9;V9GYA2;A0A2R8YEW1;A0A2R8YDY7;A0A2R8YCK2;A0A2R8YF47;V9GY80;A0A2R8YEL7;A0A2R8Y797;A0A2R8Y7T1 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 ; 104.82 0.0095955 5225700.0 13113.8 12794.9 14723.8 14614.0 15446.3 11723.599999999999 10700.900000000001 11998.5 12435.5 14832.3 False True 12384.987494700756 13776.227687912113 13776.486738061332 12623.547989443847 13505.797702325968 13338.419483755197 11198.51305343108 12033.4136485414 14922.947476901054 14404.05296005648 0.8598265730517136 0.9564132904894633 0.9564312750213126 0.876388612597433 0.9376387145880787 0.9260184977619587 0.7774556983708263 0.8354185923858347 1.0360242022355448 1.0 13.814187188624492 VYYS(ph)PPVAR ddPTM_A459_Selumetinib_30min_R1 2 VYYSPPVAR 9 0 O94964-2;H0YDM2;O94964;O94964-3 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 VYYS(1)PPVAR;VYYS(1)PPVAR 105.17 0.013905 97336000.0 7824.1 9056.0 10034.7 9561.900000000001 9251.2 7398.7 8919.4 8273.9 4074.7 7260.6 True False 8006.386306951603 7995.719309979819 8672.042856661548 7892.0936640929895 8414.430593432015 7324.275795482105 8246.602476949864 8054.449294585114 6914.468295686821 8192.568734233022 0.9772742306691371 0.9759721974097503 1.058525492795077 0.9633234605790387 1.027080866379788 0.8940145677237086 1.00659545796559 0.9831408872932894 0.8439927109545508 1.0 13.000100156442468 -6.7409984968871095 24.999847007528057 0.9483104222628389 1.000241657290782 0.21285604801348057 0.05263949733385068 411.57190710163684 503364.44078430533 0.016933555399141306 0.0169143377319028 1.8155219463660243e-07 6.7409984968871095 0.05193123502794306 VYYS(ph)PPVAR ddPTM_A459_Selumetinib_30min_R2 3 VYYSPPVAR 9 0 O94964-2;H0YDM2;O94964;O94964-3 O94964-2 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 1 VYYS(1)PPVAR;VYYS(1)PPVAR;VYYS(1)PPVAR 104.05 0.014695 77407000.0 110545.0 106638.0 105537.0 116722.0 125109.0 86465.0 82922.0 88430.0 73421.0 102572.0 True False 104401.35144669704 114816.79170478643 98746.86431999733 100824.26224331904 109391.68893134907 98374.76889887874 86778.03730682586 88687.31665962552 88107.25155414354 99610.47984593837 1.0480960598540277 1.1526577512965177 0.9913300736300362 1.0121852881268913 1.098194578527668 0.9875945688749734 0.8711737704811814 0.8903412251079699 0.8845178909931345 1.0 16.604009913272556 -7.024863686862609 4.1534076461053475 0.9036553346890367 1.0586800344672167 0.6336199806334109 0.05317847876764768 0.1350140855692592 5.31511164923305 0.02052318353933356 0.01652798266431808 9.443572376333809e-08 7.024863686862609 0.15502469977818 VYYTAGYNS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 VYYTAGYNSPVK 12 0 Q9Y5Z4-2;Q9Y5Z4 Q9Y5Z4-2 HEBP2 Heme-binding protein 2 1 VYYT(0.001)AGYNS(0.999)PVK 120.92 0.003913000000000001 7430400.0 1341.6 1730.4 2017.6 1754.2 1675.8 1524.1 1600.1 1720.8 1124.0 1571.4 True False 1372.8566697008291 1527.803963558865 1743.6210018834993 1447.8619004122518 1524.2241858865195 1508.7689377720794 1479.403168752099 1675.1587940538402 1907.3459062880677 1773.1044967321934 0.7742672088593676 0.861654779159709 0.9833718233172203 0.81656885033039 0.859635847010508 0.8509193567286752 0.8343575753592741 0.94476033259243 1.0757098128188605 1.0 10.792061847675258 -8.00076609955725 3.7840988459918905 1.03484030464466 0.8587375643235994 0.6567093512015932 0.053190531716626965 0.13947622564684978 4.350487188985878 0.03699350770222791 0.014377638190593497 9.982375455298942e-09 8.00076609955725 -0.17610274032106055 VYYTAGYNS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 1 VYYTAGYNSPVK 12 0 Q9Y5Z4-2;Q9Y5Z4 Q9Y5Z4-2 HEBP2 Heme-binding protein 2 1 VYY(0.061)T(0.284)AGYNS(0.655)PVK 147.39 0.00063095 6866500.0 43463.0 35839.0 38828.0 43554.0 46376.0 29109.0 32197.0 33905.0 29609.0 39153.0 True False 41047.50045617434 38587.736059451985 36329.848752729966 37621.87006515926 40549.83227329968 33118.500524807234 33694.224297145156 34003.65793672508 35531.62734458313 38022.551158289105 1.0795567158366695 1.014864465532836 0.9554816193549884 0.9894620144907742 1.0664679522552136 0.8710225778100436 0.8861642175685428 0.8943023784797279 0.9344882513712408 1.0 15.21456771374356 -6.765834948279107 24.999999412959916 0.9086499249478193 1.0154059129925275 0.5449107040547716 0.047039036450846394 86.69920862598696 493101.931719387 0.01641768863997364 0.014971637156266232 1.7146088132898746e-07 6.765834948279107 0.1067559880447082 WADPQISESNFS(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 WADPQISESNFSPK 14 0 D6RAW2;Q9BW91-2;Q9BW91 D6RAW2 NUDT9 ADP-ribose pyrophosphatase, mitochondrial 1 WADPQISES(0.001)NFS(0.999)PK 146.1 0.00028347 0.0 13211.0 11741.0 7979.5 13887.0 11390.0 9556.8 11231.0 9745.7 7476.1 9244.5 True False 12476.78550782318 12641.49694673473 7466.107657422704 11995.566643588812 9959.08637210806 10873.162452007211 11753.263753804302 9774.058373512507 8971.528899687182 8977.587264904441 1.3897704516443912 1.4081174121418343 0.8316385502159943 1.336168203063019 1.1093277155924217 1.211145281150653 1.3091784470590055 1.0887177239392218 0.9993251677718642 1.0 13.132112056058899 WAHDKFS(ph)GEEGEIEDDESGTENR ddPTM_A459_Selumetinib_30min_R1 1 WAHDKFSGEEGEIEDDESGTENR 23 1 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 WAHDKFS(1)GEEGEIEDDESGTENR 67.11 0.0020415 6331300.0 763.03 634.79 598.89 575.57 771.45 420.07 919.15 943.05 583.47 1010.3 True False 780.8071144020752 560.4684916941354 517.5640274672921 475.05750428701407 701.6724837105594 415.8444771930431 849.8177754880898 918.037250541884 990.1059750372762 1139.9818461553612 0.6849294285127272 0.49164685699543376 0.45401076272644125 0.416723745109772 0.6155119803679161 0.3647816661252079 0.7454660601430957 0.8053086578860926 0.8685278439972111 1.0 10.154795134780025 -7.554985013485156 2.4286559108517713 0.8900102233379735 0.5028254096727651 0.7545627189607207 0.09968476800153597 0.14559102982939678 1.720508916037681 0.05481605029591647 0.028706747800423323 2.7862173129936066e-08 7.554985013485156 -0.3871848136652084 WAHDKFS(ph)GEEGEIEDDESGTENR ddPTM_A459_Selumetinib_30min_R2 3 WAHDKFSGEEGEIEDDESGTENR 23 1 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 WAHDKFS(0.998)GEEGEIEDDES(0.001)GTENR;WAHDKFS(0.995)GEEGEIEDDES(0.002)GT(0.003)ENR;WAHDKFS(1)GEEGEIEDDESGTENR 63.726000000000006 0.0022979 163493000.0 150649.0 109899.0 140200.0 160163.0 170778.0 120526.0 183669.0 184201.0 148537.0 109001.0 True False 142276.53167572906 118327.89991901872 131179.6846382182 138348.52310341405 149323.34086530906 137127.36247390573 192209.97243321902 184736.99441388302 178248.55047054397 105853.85791139059 1.3440845188167596 1.1178421103751368 1.2392527511659297 1.3069766736251076 1.4106556323181572 1.2954403852592122 1.8158050752776196 1.7452079504605762 1.6839117060783406 1.0 16.691714324681755 -7.206663826420997 11.175362820489829 1.623251295053127 1.2824485151921232 0.2523419888375278 0.2222696157238797 1.0307012731264331 208.6417490690107 0.08109153420700169 0.06277792707662307 6.213498153050051e-08 7.206663826420997 -0.3408027798610038 WAHDKFS(ph)GEEGEIEDDESGTENREEK ddPTM_A459_Selumetinib_30min_R1 2 WAHDKFSGEEGEIEDDESGTENREEK 26 2 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 WAHDKFS(0.999)GEEGEIEDDES(0.001)GTENREEK;WAHDKFS(0.981)GEEGEIEDDES(0.017)GT(0.002)ENREEK 62.999 0.0011424000000000002 25115000.0 2474.8900000000003 3413.34 2591.95 2885.0499999999997 3102.45 2541.7 2885.54 2789.04 1242.02 2471.04 True False 2532.5501217023616 3013.7045659812848 2239.97742656222 2381.230176595809 2821.833945282036 2516.1328056789544 2667.8813946384166 2715.065599121295 2107.617226448314 2788.2220539678774 0.9083028800013712 1.0808696393791615 0.8033712463376227 0.8540317559023377 1.0120549549725877 0.9024147851130735 0.9568396429695383 0.9737623283115221 0.7559000630702978 1.0 11.445129746658003 WAHDKFS(ph)GEEGEIEDDESGTENREEK ddPTM_A459_Selumetinib_30min_R2 2 WAHDKFSGEEGEIEDDESGTENREEK 26 2 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 WAHDKFS(0.988)GEEGEIEDDES(0.01)GT(0.001)ENREEK;WAHDKFS(0.995)GEEGEIEDDES(0.004)GT(0.001)ENREEK 42.941 0.030222 28956000.0 82357.0 66903.0 64210.0 70136.0 69047.0 47039.0 58031.0 54596.0 40194.0 62780.0 True False 77779.92764119247 72034.24497294889 60078.798506562 60583.35580865163 60372.69857198812 53518.195272472716 60729.55648624504 54754.86532114567 48233.9231141941 60967.37827797075 1.2757630365302517 1.1815211184663474 0.9854253242224488 0.9937011811863021 0.9902459360599158 0.8778169044511853 0.9960991960218234 0.898101031530335 0.7911431404230546 1.0 15.89574988803861 -4.14721022644155 0.5976313185956429 0.908378852016389 1.9283496214040432 0.7863553683277023 0.061716028983869305 3.117742589819343 0.48460406955380547 0.029406727215273386 2.5912331157122988 7.125080469482928e-05 4.14721022644155 1.0199707693876543 WAHDKFSGEEGEIEDDES(ph)GTENR ddPTM_A459_Selumetinib_30min_R2 1 WAHDKFSGEEGEIEDDESGTENR 23 1 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 WAHDKFS(0.001)GEEGEIEDDES(0.936)GT(0.063)ENR 66.36 0.0022008 3819100.0 6964.8 5729.2 7939.4 8302.1 8972.8 5946.8 6792.5 6156.0 4452.7 8393.2 True False 6577.724298303453 6168.611217718472 7428.587647765119 7171.339658078681 7845.55664615023 6765.917720324425 7108.36470908341 6173.912940819335 5343.364418832962 8150.866507847476 0.8069969360890114 0.7568043485658204 0.911386248396172 0.8798254334277554 0.9625426497411901 0.8300856987180869 0.8720992672668154 0.7574547975819781 0.6555578371561462 1.0 12.99273772316206 -10.291003709622782 8.389424386372154 1.0000001609959894 0.831425238074316 0.2780180878341013 0.0837557619521761 0.0 0.0 0.08671182076943589 0.021030705648353618 5.116774649149221e-11 10.291003709622782 -0.16857492292167342 WAHDKFSGEEGEIEDDES(ph)GTENREEKDNIQPTTE ddPTM_A459_Selumetinib_30min_R1 2 WAHDKFSGEEGEIEDDESGTENREEKDNIQPTTE 34 3 Q9Y2W1 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 1 WAHDKFSGEEGEIEDDES(0.798)GT(0.201)ENREEKDNIQPT(0.001)TE;WAHDKFSGEEGEIEDDES(0.49)GT(0.49)ENREEKDNIQPT(0.018)T(0.002)E 78.221 4.3124e-06 56250000.0 3407.7 3297.8 7212.700000000001 7730.5 5094.5 4922.0 3569.9 3492.0 1948.5900000000001 2226.4 True False 3487.092779770062 2911.692042894373 6233.254956525134 6380.513294457256 4633.70337450703 4872.489148818435 3300.6195688570206 3399.380816385411 3306.614910617316 2512.1801269724815 1.388074343209013 1.1590299643056876 2.4812133849801024 2.539831131514698 1.8444948770816336 1.9395460924573298 1.3138466996929539 1.3531596639458043 1.3162332092015379 1.0 11.294724195935114 -7.281290638735349 5.711737857952523 1.2702485406601818 1.9138779725082657 0.37695419030329547 0.40605324269195125 0.22632297736588775 26.30641882670684 0.1884834991476633 0.1308443626927788 5.232501497045878e-08 7.281290638735349 0.643629431848084 WALS(ph)QSNPSALR ddPTM_A459_Selumetinib_30min_R2 1 WALSQSNPSALR 12 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 WALS(0.811)QS(0.039)NPS(0.15)ALR 90.861 0.02383 2561000.0 6331.8 8691.4 9054.4 9973.5 9182.3 6742.9 6796.4 7458.6 5583.8 9866.0 True False 5979.90390420368 9358.002432744248 8471.849761685335 8615.092094752863 8028.737383196469 7671.673269048156 7112.446066811114 7480.303291162298 6700.71602440755 9581.142945053507 0.6241326257731024 0.976710449516416 0.8842212051599886 0.8991716483262165 0.8379728211174947 0.8007054391155743 0.7423379556697965 0.780731832732355 0.699364998814359 1.0 13.225982051563625 -6.728106088619899 3.406025662686239 0.7858465811937325 0.8588715083143356 0.012907111738311827 0.11254961783235173 0.639828035335899 15.386466404084995 0.03839310132252998 0.036530888329161335 1.8702252295430655e-07 6.728106088619899 0.07302492712060304 WCNEHLK ddPTM_A459_Selumetinib_30min_R2 2 WCNEHLK 7 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;Q14315-2;Q14315;O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;Q14315-2;O75369-8 FLNA;FLNC;FLNB Filamin-A;Filamin-C;Filamin-B 0 ; 98.629 0.030536 53952000.0 306790.0 302080.0 350450.0 352370.0 357460.0 242972.0 283000.0 270660.0 255170.0 280930.0 False True 289739.8399776754 325248.5646597073 327902.428541109 304376.5981278459 312552.67906705383 276439.1875197866 296160.0607538615 271447.5757898251 306211.13004550175 272818.82095620123 1.062022916755405 1.1921778839148462 1.201905452827065 1.115673020875312 1.1456419244522413 1.013270222893334 1.0855558268152163 0.9949737882394989 1.1223973806948655 1.0 18.057583649457094 -6.749174468746184 24.888250066925004 1.0455700830506809 1.1478900264873115 0.4856425326374657 0.051455247647465924 179.8304390696885 364915.5532425055 0.016418632082828965 0.01630376880180628 1.7816628777756e-07 6.749174468746184 0.10231994343663064 WDAADDIHR ddPTM_A459_Selumetinib_30min_R1 1 WDAADDIHR 9 0 Q9HD15;R4GMW4 Q9HD15 SRA1 Steroid receptor RNA activator 1 0 117.7 0.010466 2816400.0 3437.3 3733.6 3402.7 3469.3 3691.5 3133.0 3310.6 3097.9 1833.2 2865.8 False True 3517.3824021784912 3296.4683762964482 2940.632029693191 2863.4518818266006 3357.604476787261 3101.4848645363977 3060.87877662065 3015.733628602624 3110.80650836947 3233.653345255901 1.0877425705939845 1.0194254066017012 0.9093838193903492 0.8855160328263313 1.03833160771955 0.9591271955871806 0.9465698545304094 0.9326088193797929 0.9620098929074572 1.0 11.658949311684522 -4.985735677322364 3.774824331808504 0.9523996151055028 1.081836940816344 0.5165607813339375 0.04092855415137214 0.17450717657972764 5.387772752775038 0.010766007446408111 0.047443336123321654 1.0333901619633321e-05 4.985735677322364 0.1294373257108412 WDCES(ph)ICSTYSNLYNHPQLIK ddPTM_A459_Selumetinib_30min_R1 1 WDCESICSTYSNLYNHPQLIK 21 0 Q96GA3 Q96GA3 LTV1 Protein LTV1 homolog 1 WDCES(0.972)ICS(0.027)T(0.001)YSNLYNHPQLIK 103.67 0.00011768 8097900.0 909.58 1215.5 1001.8 1212.2 1101.6 884.49 1130.5 1095.5 489.21 799.33 True False 930.7714442654152 1073.18869492938 865.7610624935016 1000.5120258121833 1001.9604745032764 875.5928336526646 1045.225474829229 1066.4437813144943 830.1536395152897 901.9317916335397 1.0319754253031068 1.189877887534785 0.9598963807733984 1.109298990337284 1.1109049307249377 0.9707971731064373 1.158874190404312 1.1823995907528635 0.920417316714994 1.0 9.816874523928519 -8.277412005995172 24.787857150022923 0.9602086440916947 1.0880574448883151 0.30135537136637003 0.07857684217895218 1030.3237007244984 1598937.0582529712 0.0725229056129574 0.018976015229688406 5.2794416465768245e-09 8.277412005995172 0.12784880079662042 WDCESICST(ph)YSNLYNHPQLIK ddPTM_A459_Selumetinib_30min_R1 1 WDCESICSTYSNLYNHPQLIK 21 0 Q96GA3 Q96GA3 LTV1 Protein LTV1 homolog 1 WDCES(0.232)ICS(0.295)T(0.437)Y(0.006)S(0.029)NLY(0.002)NHPQLIK 81.477 0.0023953000000000004 11908000.0 934.36 1605.2 1229.0 1534.2 1512.2 1559.2 1719.1 1600.8 543.8 964.38 True False 956.1287700519289 1417.2624377627656 1062.1085504137689 1266.2807705007842 1375.421777000595 1543.5158636403291 1589.4269029446505 1558.3415838687756 922.7888824194406 1088.1675668566836 0.8786594998542676 1.302430325006576 0.9760523863818238 1.1636817794143637 1.2639797572479423 1.4184542074700677 1.4606453558765045 1.4320786902060056 0.848020939536949 1.0 10.08768501887794 -6.101588515451374 3.4428426177181106 1.2788009712733912 1.076120725763376 0.11176543169219644 0.20993247126863745 0.4717908540896149 10.433129885424673 0.06342818899948674 0.08630255685862902 7.914281337674204e-07 6.101588515451374 -0.20268024551001518 WDEQTSNTKGDDDEES(ph)DEEAVK ddPTM_A459_Selumetinib_30min_R2 3 WDEQTSNTKGDDDEESDEEAVK 22 1 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 WDEQTSNTKGDDDEES(1)DEEAVK;WDEQT(0.001)S(0.001)NT(0.004)KGDDDEES(0.994)DEEAVK;WDEQTSNTKGDDDEES(1)DEEAVK 79.558 0.00070933 38290000.0 197603.0 167678.0 172083.0 142544.0 131694.0 111926.0 154825.0 158128.0 108895.0 144023.0 True False 186621.0163274833 180538.36343025166 161011.36712980433 123129.26129788462 115149.4223607022 127342.79053693291 162024.66927991732 158588.12630050018 130677.0427805189 139864.6817733066 1.3342969358766326 1.2908073799708004 1.1511938903258823 0.8803456293380281 0.8232916337473744 0.9104713850729719 1.1584387654241959 1.13386828103996 0.9343105144465342 1.0 17.09367217773098 -5.480241921108546 3.2645925678301118 0.9816934045564454 1.3096630950198498 0.6435395309813687 0.10026202802798415 0.1756776517418575 3.7427698867632135 0.031822797101862366 0.06991098907573803 3.3094671826372945e-06 5.480241921108546 0.3279696904634044 WDEQTSNTKGDDDEES(ph)DEEAVKK ddPTM_A459_Selumetinib_30min_R1 1 WDEQTSNTKGDDDEESDEEAVKK 23 2 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 WDEQTSNTKGDDDEES(1)DEEAVKK 112.06 1.5639e-05 11934000.0 976.21 1352.8 1069.4 1448.6 937.06 1157.2 1134.7 859.55 765.24 1031.4 True False 998.9537936260039 1194.4135471003417 924.1813537937221 1195.6292035897782 852.3030884513798 1145.5596186535329 1049.1086654477886 836.7519417881099 1298.5563890817436 1163.790236686766 0.8583624111420279 1.026313427839675 0.7941133416145554 1.027357994507374 0.7323511244413172 0.9843351340657964 0.9014585553102178 0.7189886247630736 1.1157993495276675 1.0 10.184615332802723 -8.28776853053671 24.997895133829786 1.0578997036291273 0.8865256944495281 0.29976819540021016 0.10818524847487421 1048.563434050489 995535.6700959511 0.09667436262740595 0.024993694116315752 5.15503323376576e-09 8.28776853053671 -0.17137400917959922 WDEQTSNTKGDDDEES(ph)DEEAVKK ddPTM_A459_Selumetinib_30min_R2 3 WDEQTSNTKGDDDEESDEEAVKK 23 2 O43395 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 1 WDEQTSNTKGDDDEES(1)DEEAVKK;WDEQT(0.002)S(0.005)NT(0.013)KGDDDEES(0.981)DEEAVKK;WDEQTSNTKGDDDEES(1)DEEAVKK 85.15700000000002 0.00031841 95020000.0 162240.0 141034.0 133917.0 112653.0 106380.0 81198.0 109377.0 114752.0 70218.0 117843.0 True False 153223.3502981781 151850.85430421468 125300.9260178054 97309.46706273562 93015.59335073346 92382.28745794424 114463.24722641373 115085.90932178378 84263.562054846 114440.56639711544 1.3388901778630151 1.3268970880245676 1.0948995619525674 0.8503057099968039 0.8127851537186903 0.8072512253860429 1.0001981887193705 1.0056391098452708 0.7363085023753424 1.0 16.804239017513652 -5.470858634447826 2.625057321213036 0.8861318500568045 1.3386783478584914 0.8029725405977083 0.08819853624694833 0.1189768687553362 1.601552775069227 0.02562948785931054 0.06141844795787855 3.381748963222512e-06 5.470858634447826 0.4525464978016869 WDGS(ph)EEDEDNSK ddPTM_A459_Selumetinib_30min_R1 10 WDGSEEDEDNSK 12 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK 275.35 1.9298e-34 158462600.0 27311.8 30260.0 34376.4 35836.2 26353.5 27912.299999999996 26950.7 25601.0 17106.6 23560.7 True False 27948.111800488306 26717.145132507652 29708.27369604871 29578.080398787788 23969.830578088327 27631.52760434066 24917.78700086695 24921.97831623221 29028.650783369616 26584.945345652428 1.0512758795292692 1.0049727311881362 1.117484851286597 1.112587594754068 0.9016317418161718 1.0393674782882103 0.9372893822759685 0.937447039751309 1.0919206492977358 1.0 14.6983218800256 -6.245484314462957 24.877111891984356 0.9818536338196359 1.070101481135602 0.3421973416346049 0.05898454838383685 901.1098875629341 1405008.6754820952 0.01732182798938681 0.02228493555974273 5.682189137130511e-07 6.245484314462957 0.08824784731596613 WDGS(ph)EEDEDNSK ddPTM_A459_Selumetinib_30min_R2 8 WDGSEEDEDNSK 12 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK;WDGS(1)EEDEDNSK 231.07 9.8225e-14 972304700.0 440461.0 408514.0 397495.0 384169.0 362646.0 287496.6 353712.0 371627.0 260366.0 344630.0 True False 415981.94092508534 439845.71022045735 371920.6044598333 331844.5194715103 317087.1673836262 327096.6470157095 370160.3088670312 372708.37304383825 312446.4752338717 334679.63644372515 1.2429257583319706 1.314229078572623 1.111273480549421 0.9915288632366746 0.9474348984986511 0.9773425431299263 1.1060138369944474 1.1136272795208066 0.9335688258595565 1.0 18.352421247464846 -5.448141627333027 3.404290325200399 1.0155545309930143 1.2774468926286022 0.7643629310713339 0.05897256172576489 0.1200315237370487 2.661168906822628 0.01733534695378365 0.038845316626985864 3.5633491046034624e-06 5.448141627333027 0.26189236163558793 WDGS(ph)EEDEDNSKK ddPTM_A459_Selumetinib_30min_R1 6 WDGSEEDEDNSKK 13 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 WDGS(0.997)EEDEDNS(0.003)KK;WDGS(1)EEDEDNSKK;WDGS(1)EEDEDNSKK;WDGS(0.979)EEDEDNS(0.021)KK;WDGS(1)EEDEDNSKK;WDGS(1)EEDEDNSKK 228.17 1.0478e-12 764287500.0 31114.899999999998 36957.2 43250.899999999994 45107.9 30022.5 32596.500000000004 33986.9 33672.5 21239.7 30180.6 True False 31839.81663094391 32630.233843063823 37377.66534018786 37230.6520451521 27306.970175902883 32268.608805253967 31423.24076998983 32779.39591630516 36042.219613689194 34054.573993938924 0.9349644672287136 0.9581747770173661 1.097581351240523 1.0932643600762253 0.8018591035895211 0.947555791213162 0.9227318707784328 0.9625548662608224 1.0583664802297639 1.0 15.055560964429768 -1.6216538408067378 20.835748644875636 0.9754133700867238 0.025498845062120856 0.0 0.08489445491733426 0.0 0.0 0.020402564241184928 0.0 0.0238971527285513 1.6216538408067378 -0.9499145250246029 WDGS(ph)EEDEDNSKK ddPTM_A459_Selumetinib_30min_R2 4 WDGSEEDEDNSKK 13 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 1 WDGS(1)EEDEDNSKK;WDGS(1)EEDEDNSKK;WDGS(1)EEDEDNSKK;WDGS(1)EEDEDNSKK 231.07 6.6801e-13 187253300.0 341439.0 307413.0 310979.0 290800.0 277204.0 215127.0 288013.0 270032.0 185094.0 261421.0 True False 322463.1872686125 330990.5886114101 290970.9497083349 251192.53834201986 242379.15528479713 244758.79152152952 301406.17518693284 270817.74841379595 222117.97195846788 253873.0964766714 1.270174712263156 1.3037639403505092 1.146127548552875 0.9894413462007076 0.9547256430421707 0.9640989727480659 1.1872316498673552 1.06674457503488 0.8749173309070127 1.0 17.95374799176883 -5.507836355571777 2.9957369469439934 1.0121473148441102 1.285765665696696 0.6797253910870653 0.07757291557541865 0.1579845873718216 2.8549808739629112 0.023068413444703638 0.05045481172616403 3.105729622813747e-06 5.507836355571777 0.2736183508525858 WDKDDFES(ph)EEEDVK ddPTM_A459_Selumetinib_30min_R1 2 WDKDDFESEEEDVK 14 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;Q7Z6E9-4 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 WDKDDFES(1)EEEDVK;WDKDDFES(1)EEEDVK 108.97 0.0025938000000000003 178812000.0 12271.4 15414.9 11866.900000000001 11361.9 8901.0 11542.5 12494.3 11872.4 7338.200000000001 12573.6 True False 12557.299744012194 13610.116341807407 10255.44016021575 9377.757454277717 8095.9061215991915 11426.392929751479 11551.844891781362 11557.505385009772 12452.389439077479 14187.544037235526 0.8850932699172797 0.9593003768719486 0.7228481640867594 0.6609852578899902 0.5706347836067542 0.8053820238205186 0.8142244254159344 0.8146234016738092 0.8776987339313911 1.0 13.792337249993722 -8.492295092683108 1.093218631180124 0.9978883007532098 0.765534178593179 0.3227753904255536 0.10270504552724877 0.715323098843374 1.8776849403908773 0.11098999761261566 0.035907736511214504 3.2188808956984307e-09 8.492295092683108 -0.23235412216003082 WDKDDFES(ph)EEEDVK ddPTM_A459_Selumetinib_30min_R2 1 WDKDDFESEEEDVK 14 1 Q7Z6E9;A0A2R8Y880;Q7Z6E9-2;Q7Z6E9-4 Q7Z6E9 RBBP6 E3 ubiquitin-protein ligase RBBP6 1 WDKDDFES(1)EEEDVK 69.612 0.032999 21184000.0 88583.0 69693.0 61594.0 69198.0 59549.0 57092.0 73694.0 67985.0 50430.0 70582.0 True False 83659.91148584514 75038.22900168483 57631.109098476576 59773.11302679179 52067.922245185495 64955.90477042477 77120.91702189064 68182.82509447739 60517.409131930355 68544.1142659404 1.2205265525973217 1.094743579449408 0.8407885887164129 0.8720385939320989 0.7596264508309223 0.947651092527158 1.1251282162998502 0.9947291000061469 0.8828972374948535 1.0 16.064745169785972 -5.035359239206973 4.024185886285981 0.9279550142731322 1.2031658323425973 0.5012316788517799 0.09537860028204602 0.1827396246065094 6.40901314450981 0.02747799970342205 0.09883361015141005 9.218086111253885e-06 5.035359239206973 0.2752108180694651 WDQTADQT(ph)PGATPK ddPTM_A459_Selumetinib_30min_R1 2 WDQTADQTPGATPK 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 WDQTADQT(0.94)PGAT(0.06)PK;WDQTADQT(0.994)PGAT(0.006)PK 195.38 0.00018471 95503000.0 10924.5 14522.3 14318.3 15152.2 10431.1 12344.099999999999 11896.900000000001 11610.1 7007.3 10261.0 True False 11179.019594623374 12822.022364765893 12373.953504792076 12506.152712020594 9487.608846760288 12219.92956154604 10999.507254750859 11302.162433080248 11890.876307057268 11578.099300603944 0.9655315008431692 1.107437588145151 1.0687378976052329 1.0801559381485215 0.8194444183308558 1.0554348554350899 0.9500270268175274 0.9761673431571534 1.027014538253011 1.0 13.499110814684961 WDQTADQT(ph)PGATPK ddPTM_A459_Selumetinib_30min_R2 2 WDQTADQTPGATPK 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 WDQTADQT(0.999)PGAT(0.001)PK;WDQTADQT(0.999)PGAT(0.001)PK 237.06 5.5459e-19 207210000.0 96984.0 83728.0 90756.0 95452.0 91278.0 68824.0 73280.0 83524.0 63900.0 76443.0 True False 91594.0175377127 90149.66837204708 84916.85776766166 82451.27293611552 79810.84160432662 78303.88127793248 76687.66520156532 83767.04101185735 76681.78551517648 74235.89196723339 1.2338238971809072 1.2143676863455455 1.1438787292424895 1.110665888846709 1.075097765910241 1.0547981468653282 1.0330267902676258 1.1283900387272354 1.0329475875230634 1.0 16.17982925700739 -5.463099222598193 0.9093511194612058 1.054766238424488 1.262866521431866 0.8265803694032718 0.030997501245370665 0.3810037738592281 0.47684423438655876 0.011912129840473969 0.06428140626996483 3.4427126664610054e-06 5.463099222598193 0.20810028300737793 WDQTADQTPGAT(ph)PK ddPTM_A459_Selumetinib_30min_R1 2 WDQTADQTPGATPK 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 WDQTADQT(0.191)PGAT(0.808)PK;WDQTADQT(0.001)PGAT(0.999)PK 195.28 0.00029015 135141000.0 7675.9 8625.5 9659.7 8892.400000000001 6409.1 7513.299999999999 7816.099999999999 7083.1 4703.6 7050.599999999999 True False 7854.733535298602 7615.6224501138395 8347.965796933999 7339.509271021497 5829.398036618508 7437.723023530579 7226.525284221792 6895.233178848654 7981.665662648181 7955.613188659794 0.9873196885055964 0.9572640435773588 1.0493177080094187 0.9225573311537427 0.7327402550098757 0.9349025458065968 0.9083555362549214 0.8667129755224094 1.0032747285935826 1.0 12.957757416996564 -5.962640443501934 11.303587042160807 0.8956174771371722 0.9926707057257401 0.21732063800432733 0.07486468078614271 0.9046138726633499 269.52501225317377 0.02092728930891352 0.03102274193083049 1.089832002126958e-06 5.962640443501934 0.09705322858856791 WDQTADQTPGAT(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 WDQTADQTPGATPK 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 WDQTADQT(0.009)PGAT(0.991)PK;WDQTADQTPGAT(1)PK;WDQTADQTPGAT(1)PK 190.46 0.00023854 27699700.0 174162.0 156634.0 168487.0 168400.0 160276.0 117916.0 146223.0 133822.0 94854.0 141878.0 True False 164482.77326572555 168647.32414230876 157646.72985477498 145463.62949379685 140140.69599438042 134157.8586651266 153022.6592353778 134211.39986457542 113827.45044219971 137781.61349668555 1.193793345072725 1.2240190825343014 1.1441782822391415 1.055755015507175 1.0171218962953401 0.9736992858510392 1.1106174136874867 0.9740878805124749 0.8261439792540819 1.0 17.07202385241382 -5.605158947086083 0.5423960837720773 0.9537610540519998 1.2963113711166108 0.675367469971021 0.06465657805856163 1.1880361824995966 0.49247756669304005 0.04547994826695354 0.2333223096260846 2.482224471704424e-06 5.605158947086083 0.3425503170646109 WDS(ph)YDNFSGHR ddPTM_A459_Selumetinib_30min_R2 2 WDSYDNFSGHR 11 0 E9PGF5;E9PF55;A0A494C067;A0A2R8Y4T1;Q9HBL0;E7ERH1;H7C3Z4;E7EMG1;Q9HBL0-2 E9PGF5 TNS1 Tensin-1 1 WDS(1)YDNFSGHR;WDS(0.999)Y(0.001)DNFSGHR 151.3 0.00039578 6729100.0 39440.0 23378.6 39374.0 46605.0 44638.0 34017.0 44695.0 42869.0 36804.0 28748.0 True False 37248.082690829324 25171.663445952843 36840.71970716979 40257.31860189073 39030.1753712168 38702.53297441918 46773.406061462345 42993.741692654985 44165.82838968006 27917.97054372576 1.3341973633968318 0.9016294148791514 1.3196059380272291 1.4419858541951966 1.3980305377171613 1.3862946417900395 1.6753870410531728 1.540002401869334 1.5819856361158677 1.0 14.768906450290453 -5.510258550941926 4.67978637092478 1.457917199368222 1.1125245684193132 0.28049684975216016 0.19563997843196007 0.20021736635948487 11.528604761231039 0.050538792086199755 0.10044279692996647 3.0884562173285273e-06 5.510258550941926 -0.3453926309489088 WDS(ph)YENLSADGEVLHTQGPVDGSLY(ph)AK ddPTM_A459_Selumetinib_30min_R1 1 WDSYENLSADGEVLHTQGPVDGSLYAK 27 0 Q68CZ2;Q68CZ2-3;E9PCX8;C9JHU5 Q68CZ2;E9PCX8 TNS3 Tensin-3 2 WDS(0.982)Y(0.001)ENLS(0.013)ADGEVLHT(0.023)QGPVDGS(0.056)LY(0.925)AK 76.972 0.0019557000000000003 12840000.0 1993.2 2640.5 2600.5 2583.3 2163.0 2142.8 2240.9 2049.6 1309.2 2117.6 True False 2039.6376819079405 2331.3490324648524 2247.366383524009 2132.1751495467856 1967.357031908666 2121.2453775067315 2071.867108841059 1995.2379499609212 2221.6167798152464 2389.414587170735 0.8536139742592936 0.9756988364356488 0.940551043586403 0.8923420661256855 0.8233636148669284 0.8877678193211592 0.8671023940195833 0.8350321290720203 0.9297745111892971 1.0 11.222441482098905 -2.0167823188859413 19.375118463487823 0.8954888075015733 0.15730014226635036 0.0 0.05661114011031999 0.0 0.0 0.01294967057276149 0.0 0.00962094387435034 2.0167823188859413 -0.738188665235223 WDS(ph)YENLSADGEVLHTQGPVDGSLYAK ddPTM_A459_Selumetinib_30min_R1 9 WDSYENLSADGEVLHTQGPVDGSLYAK 27 0 Q68CZ2;Q68CZ2-3;E9PCX8;C9JHU5 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 WDS(0.904)Y(0.001)ENLS(0.095)ADGEVLHTQGPVDGSLYAK;WDS(0.611)YENLS(0.389)ADGEVLHTQGPVDGSLYAK;WDS(1)YENLSADGEVLHTQGPVDGSLYAK;WDS(0.954)YENLS(0.046)ADGEVLHTQGPVDGSLYAK;WDS(0.799)Y(0.049)ENLS(0.152)ADGEVLHTQGPVDGSLYAK;WDS(0.908)Y(0.054)ENLS(0.038)ADGEVLHTQGPVDGSLYAK;WDS(0.981)Y(0.001)ENLS(0.017)ADGEVLHTQGPVDGSLYAK;WDS(0.981)Y(0.008)ENLS(0.012)ADGEVLHTQGPVDGSLYAK;WDS(0.999)YENLS(0.001)ADGEVLHTQGPVDGSLYAK 171.88 5.5305e-22 208817900.0 11477.45 14097.07 11549.580000000002 12043.029999999999 12084.539999999999 10967.91 12833.710000000001 12387.65 6198.150999999999 11349.999999999998 True False 11744.852253769972 12446.578490849952 9981.210473301762 9939.94088617134 10991.49549069882 10857.5827834655 11865.65292222081 12059.089281241904 10517.809551961993 12806.883058362224 0.917073436233276 0.9718663342305596 0.7793629744112136 0.7761405207554448 0.8582490712696833 0.8477927637807285 0.9265059162442465 0.9416100097336292 0.8212622465615795 1.0 13.644631774556508 -7.261092014747896 24.04086958179682 0.9174787128271235 0.8562306441743044 0.1733035047215583 0.06797277306090498 38.65904994229655 2675725.706135967 0.02874199951114469 0.020876054985631096 5.481608128057249e-08 7.261092014747896 -0.061248068652819065 WDS(ph)YENLSADGEVLHTQGPVDGSLYAK ddPTM_A459_Selumetinib_30min_R2 4 WDSYENLSADGEVLHTQGPVDGSLYAK 27 0 Q68CZ2;Q68CZ2-3;E9PCX8;C9JHU5 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 WDS(0.985)Y(0.014)ENLS(0.001)ADGEVLHTQGPVDGSLYAK;WDS(0.757)Y(0.002)ENLS(0.24)ADGEVLHT(0.001)QGPVDGSLYAK;WDS(0.921)Y(0.014)ENLS(0.065)ADGEVLHTQGPVDGSLYAK;WDS(0.84)Y(0.054)ENLS(0.105)ADGEVLHTQGPVDGSLYAK 146.37 7.448200000000002e-14 101319000.0 240768.0 209667.6 241378.0 278911.9 283364.5 220439.6 240421.4 250968.7 229861.8 255401.8 True False 227387.07843066906 225748.43073240793 225848.00227249495 240923.6180701355 247765.71819922864 250803.15394854872 251601.47148596618 251698.97736689524 275840.5828753112 248027.686420431 0.9167810324417811 0.9101743196110067 0.9105757729387544 0.9713577606886458 0.9989437944409225 1.0111901520679953 1.0144088150686421 1.0148019400553574 1.1121362572714346 1.0 17.920141646790995 -6.191252008132988 0.8303374791091114 1.0404054615092173 0.8998567961349934 0.7566493238778966 0.029179802062594573 0.3219953018404452 0.4705337988822249 0.015006496822537995 0.027624577806272015 6.437955817350152e-07 6.191252008132988 -0.14054866537422395 WDSYENLS(ph)ADGEVLHTQGPVDGSLYAK ddPTM_A459_Selumetinib_30min_R1 3 WDSYENLSADGEVLHTQGPVDGSLYAK 27 0 Q68CZ2;Q68CZ2-3;E9PCX8;C9JHU5 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 WDS(0.111)Y(0.006)ENLS(0.883)ADGEVLHTQGPVDGSLYAK;WDS(0.084)YENLS(0.916)ADGEVLHTQGPVDGSLYAK;WDS(0.394)YENLS(0.606)ADGEVLHTQGPVDGSLYAK 195.97 6.205599999999998e-40 544681000.0 9821.26 11257.42 9512.41 10006.75 10109.6 9787.52 11085.09 10686.64 5605.21 8608.720000000001 True False 10050.076249154723 9939.39603296743 8220.676969927936 8259.258962461698 9195.188464994846 9689.066435157134 10248.932736642835 10403.195592101078 9511.631981659193 9713.733068033838 1.0346255326109104 1.0232313327279097 0.8462943043988636 0.8502662060625739 0.9466173715700064 0.9974606433279624 1.0550972180170612 1.070978121309112 0.9791942927647741 1.0 13.245810126519393 -6.864966182518147 3.269399363931855 1.0315907788505814 0.934055188082591 0.29840929664639904 0.06228580746886341 0.32011450960342863 6.775157042210235 0.025859431437162607 0.022752304046391586 1.3646893975802508e-07 6.864966182518147 -0.09753559076799034 WDSYENLS(ph)ADGEVLHTQGPVDGSLYAK ddPTM_A459_Selumetinib_30min_R2 2 WDSYENLSADGEVLHTQGPVDGSLYAK 27 0 Q68CZ2;Q68CZ2-3;E9PCX8;C9JHU5 Q68CZ2;E9PCX8 TNS3 Tensin-3 1 WDS(0.061)Y(0.038)ENLS(0.901)ADGEVLHT(0.001)QGPVDGSLYAK;WDS(0.175)Y(0.001)ENLS(0.824)ADGEVLHTQGPVDGSLYAK 138.24 2.2057e-12 50397200.0 177430.5 139759.7 183220.4 204325.9 205671.5 171781.0 183571.3 198099.9 157319.0 187194.5 True False 167569.62312056782 150478.8195917352 171432.19893928844 176496.35993816252 179833.20744346132 195442.27347734076 192107.72918963002 198676.33791179617 188787.19586012606 181789.7083952783 0.921777281012021 0.8277631386290493 0.9430247754539063 0.9708820234993387 0.9892375593256202 1.0751008690347679 1.0567580028893413 1.0928910094283228 1.038492209083875 1.0 17.471911001431046 -6.002574881351378 1.1173928246330704 1.0584078415056637 0.8734723289616534 0.7748003375611509 0.03622152576471415 0.2142508566368724 0.5442972318174965 0.013780298807142592 0.02767323314777901 9.940886577297788e-07 6.002574881351378 -0.1849355125440103 WDVDDWDNENSSAR ddPTM_A459_Selumetinib_30min_R2 2 WDVDDWDNENSSAR 14 0 A0A087WUZ3;Q01082;Q01082-2;F8W6C1 A0A087WUZ3 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 ; 224.25 3.4279e-08 7896200.0 34356.0 31084.0 39007.0 33515.0 34764.0 29034.0 32613.0 35083.0 25586.0 31750.0 False True 32446.63105796482 33468.04284918681 36497.33208761042 28950.199183400215 30396.635525896796 33033.16995558946 34129.56912143352 35185.085721696705 30703.914932571315 30833.29500359304 1.0523244776201757 1.0854513877056193 1.1836987283829814 0.9389265461257583 0.9858380533885411 1.0713473844342638 1.1069063205037397 1.1411393338790599 0.9958038843721811 1.0 14.912201451003385 WEADTLDKEGLSES(ph)VR ddPTM_A459_Selumetinib_30min_R1 2 WEADTLDKEGLSESVR 16 1 Q6PHR2-3;Q6PHR2;Q6PHR2-4 Q6PHR2-3 ULK3 Serine/threonine-protein kinase ULK3 1 WEADTLDKEGLS(0.025)ES(0.975)VR;WEADTLDKEGLS(0.019)ES(0.981)VR 70.555 0.023247 27356000.0 5327.4 7109.8 7981.4 8881.0 6560.2 7371.8 6056.200000000001 5616.5 3567.7 5016.3 True False 5451.518054684111 6277.381310743654 6897.569718691991 7330.100067016994 5966.831068297378 7297.64638505886 5599.375958125408 5467.532175036839 6054.126325501718 5660.190967899773 0.9631332380127997 1.1090405511658719 1.2186107779418882 1.295026989122391 1.054174868328053 1.2892933165056566 0.9892556611394809 0.9659624924396465 1.0695975382873197 1.0 12.46663501330127 -7.296761692936184 24.711229636796507 1.0033674117453732 1.157486040480538 0.35367208774220216 0.09839518859904012 611.436564649987 427754.02736514003 0.041887816445693817 0.028242047528375672 5.0493829245744974e-08 7.296761692936184 0.1541186287351648 WEAERDDWLHNR ddPTM_A459_Selumetinib_30min_R1 2 WEAERDDWLHNR 12 1 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 ; 141.71 0.00077186 23503400.0 11871.4 11409.3 17381.4 19658.6 14620.2 13439.599999999999 11213.7 9859.6 6766.7 7452.1 False True 12147.980522276703 10073.493851960331 15021.101349195991 16225.594547625291 13297.805491405965 13304.409826180448 10367.841580798335 9598.091379505611 11482.595679786004 8408.649624600983 1.4447005244142472 1.1979918657198598 1.7863868777751326 1.9296314238322478 1.581443642567874 1.5822290641360603 1.232997216397909 1.141454550731274 1.365569525716906 1.0 13.037658416139445 -7.280525264041669 4.268558556052162 1.1900710583114418 1.5959922481604742 0.4940542364716767 0.19964246418762463 0.20920998251295417 9.38992648112178 0.0930089050650704 0.06426754123481594 5.241731076060046e-08 7.280525264041669 0.40592118984903247 WEGGDSNS(ph)DDYDLESDMSNGWDPNEMFK ddPTM_A459_Selumetinib_30min_R1 1 WEGGDSNSDDYDLESDMSNGWDPNEMFK 28 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 WEGGDS(0.044)NS(0.947)DDY(0.001)DLES(0.004)DMS(0.004)NGWDPNEMFK 106.21 7.5676e-10 1689100.0 604.71 705.04 739.4 699.76 634.9 545.24 634.41 445.22 357.0 608.1 True False 618.7985664391692 622.4935890357959 638.9935412334747 577.5600521220368 577.4734071006993 539.75538063831 586.5559429335788 433.41131932162443 605.8029257516366 686.1555583956008 0.9018342252973529 0.907219334477648 0.9312662900051376 0.8417334014935524 0.8416071254322753 0.7866370446672325 0.8548439719778556 0.6316516918336214 0.8828944374773438 1.0 9.422391876791561 -5.973226710844613 2.3227002189062236 0.8126461258477791 0.9132488619732109 0.11856514554449915 0.08775346572008595 0.4840421616737568 5.265747533597367 0.0262214790166724 0.041217401624860484 1.0635876581772721e-06 5.973226710844613 0.1006027361254318 WEGGDSNSDDY(ph)DLESDMSNGWDPNEMFK ddPTM_A459_Selumetinib_30min_R1 1 WEGGDSNSDDYDLESDMSNGWDPNEMFK 28 0 H3BUF6;Q8WWM7-7;H3BSK9;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7;Q8WWM7-3 H3BUF6;Q8WWM7-6 ATXN2L Ataxin-2-like protein 1 WEGGDS(0.021)NS(0.301)DDY(0.675)DLES(0.003)DMSNGWDPNEMFK 81.15100000000002 0.00025095 3231100.0 638.27 594.79 823.49 778.16 733.23 1006.4 736.75 693.78 544.28 670.13 True False 653.1404491427764 525.151710289631 711.6645811067813 642.268963872305 666.9094759622706 996.2765297380882 681.1763543391723 675.3787006849568 923.6034073616268 756.1477131189671 0.8637736222843219 0.6945094208160453 0.9411713726823279 0.849396159942171 0.8819830628216733 1.317568660795964 0.9008509085208338 0.8931835525880872 1.2214589706975856 1.0 9.562524281585981 -6.546839978351083 24.984092788930745 1.0551540810698188 0.8383506326185878 0.40264885393898053 0.13477216057503902 245.91816302342824 256414.09701442198 0.044266597646442286 0.0442684834946257 2.8389648905846504e-07 6.546839978351083 -0.216803448451231 WERS(ph)IPLR ddPTM_A459_Selumetinib_30min_R1 1 WERSIPLR 8 1 Q9H977;Q9H977-4 Q9H977 WDR54 WD repeat-containing protein 54 1 WERS(1)IPLR 76.332 0.030832 3993100.0 236.04 243.8 225.17 247.67 329.37 181.54 380.33 241.94 0.0 0.0 True False 241.5392727461121 215.255782660455 194.59315077027523 204.41908384169557 299.5785416549964 179.7138724251317 351.6414018945601 235.52296526812304 0.0 0.0 0.0 WES(ph)QQDVSQTTVSR ddPTM_A459_Selumetinib_30min_R1 2 WESQQDVSQTTVSR 14 0 Q9NQT8;H0YBA8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 WES(1)QQDVSQTTVSR;WES(1)QQDVSQTTVSR 298.1 7.200399999999999e-80 24776000.0 2725.8999999999996 3062.0 2932.2 2683.2 2462.8 2297.3 2998.3 2749.5 1408.67 2671.3 True False 2789.4081663219213 2703.4996165148204 2534.0233454216877 2214.6294899020363 2240.0401748426566 2274.191247781508 2772.135817054823 2676.5743283653164 2390.4101048138896 3014.1873756654654 0.9254262654145986 0.8969248688190621 0.8406986791463924 0.7347351753183876 0.7431655354034206 0.7544956448765623 0.9196959152026164 0.8879920173424483 0.7930529216970594 1.0 11.557553388904005 -9.956766451446532 8.592710289800758 0.9999999997113639 0.831360850994953 0.3399978620515617 0.06981045944497095 0.0 0.0 0.07518278880227885 0.018234504809992967 1.1046725148760624e-10 9.956766451446532 -0.16863914871641084 WES(ph)QQDVSQTTVSR ddPTM_A459_Selumetinib_30min_R2 3 WESQQDVSQTTVSR 14 0 Q9NQT8;H0YBA8 Q9NQT8 KIF13B Kinesin-like protein KIF13B 1 WES(0.999)QQDVS(0.001)QTTVSR;WES(1)QQDVSQTTVSR;WES(1)QQDVSQTTVSR 248.1 2.4186999999999995e-27 25678000.0 87962.0 68734.0 75374.0 85721.0 82862.0 77101.0 72624.0 88341.0 66934.0 75227.0 True False 83073.42417978514 74005.67678535602 70524.51890100604 74045.65192302714 72452.13476432116 87720.9628968074 76001.15990172596 88598.05768436016 80322.67029221929 73055.00104678089 1.1371353499343453 1.01301315070773 0.9653619586679022 1.0135603430573066 0.9917477753224084 1.200752332350733 1.0403279558241125 1.2127582836885629 1.0994821592129544 1.0 16.156695416964673 -6.740784924953123 24.999785352416467 1.1195655543106535 1.0196883842658158 0.25265846845717077 0.07339073789617324 292.9131930562386 354536.2665295275 0.023245912966537503 0.02322129593324495 1.8164149807129067e-07 6.740784924953123 -0.09987717004483776 WETTMGEASASIPTTVGSLPS(ph)SK ddPTM_A459_Selumetinib_30min_R1 1 WETTMGEASASIPTTVGSLPSSK 23 0 A0A2R8Y6S1;A0A2R8YFV7;A0A2R8Y5N2;A0A2R8Y5S3;Q92574-2;Q92574 A0A2R8Y6S1 TSC1 Hamartin 1 WETTMGEASASIPT(0.007)T(0.01)VGS(0.403)LPS(0.433)S(0.147)K 139.12 2.3147e-06 8371500.0 1821.1 2088.4 2634.2 2796.2 2191.7 2012.6 2303.1 1510.8 1186.2 1878.8 True False 1863.528086756248 1843.889157129181 2276.490108624857 2307.896161174745 1993.461121976064 1992.35507129459 2129.375312763551 1470.7286762299764 2012.8947633798086 2119.9622810617575 0.8790383222398289 0.8697745113680473 1.0738351945982285 1.088649633907101 0.9403285802696749 0.9398068489674934 1.0044401882929157 0.6937522848252657 0.949495555350954 1.0 11.049822880861294 WGDEHIPGSPYR ddPTM_A459_Selumetinib_30min_R1 1 WGDEHIPGSPYR 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 128.35 0.034127 7968200.0 2209.7 2071.6 2733.0 2917.6 2794.2 2215.4 2242.1 2474.1 1330.5 2128.7 False True 2261.181710672275 1829.0561089392872 2361.873611294411 2408.0959301349817 2541.4651033560767 2193.11508742226 2072.976591874934 2408.478830990589 2257.7613241247973 2401.939380293893 0.9413983255462528 0.7614913698261153 0.9833194087543626 1.0025631578763388 1.058088777846305 0.9130601319147021 0.8630428431633823 1.0027225710816632 0.939974315192145 1.0 11.229984025691909 -5.288361851869986 24.62108576022253 0.9688496922542159 0.8514448216476777 0.34584202221189275 0.06538494777925655 599.5538173797752 548301.9412768048 0.01741745067342403 0.03627488258945278 5.147995375842881e-06 5.288361851869986 -0.11740487060653826 WGDYDSHDIER ddPTM_A459_Selumetinib_30min_R1 4 WGDYDSHDIER 11 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 ;;; 218.55 2.1804e-05 47769000.0 30315.9 39055.4 35897.5 41243.4 36167.5 32822.299999999996 33686.4 30787.0 15770.2 26581.600000000002 False True 31022.201485527265 34482.77561163713 31022.816670852924 34041.014424502704 32896.15601089074 32492.13746226397 31145.407726923757 29970.428749730116 26760.877590163756 29993.60728671024 1.0342937809708797 1.1496708375893145 1.0343142915190036 1.1349423261798128 1.0967722453799875 1.0833020900643984 1.038401531006371 0.9992272174280818 0.8922193764276275 1.0 14.872367422985972 -7.7020595387385855 1.8615830619543425 0.9471861637820128 1.0916727311920722 0.6341146309103977 0.0431593357217369 0.20414747254194704 1.3823372757591577 0.028208891478256212 0.012027560192482764 1.9858226562861583e-08 7.7020595387385855 0.14448656741005939 WGDYDSHDIER ddPTM_A459_Selumetinib_30min_R2 3 WGDYDSHDIER 11 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 ;; 147.62 0.00093184 18484500.0 126501.0 116353.0 140861.0 129520.0 156771.0 103841.0 108824.0 118630.0 97724.0 119780.0 False True 119470.58084362582 125276.9009661378 131798.15661786075 111879.15256553757 137076.02542947783 118144.1551752553 113884.53163066515 118975.19365974615 117271.53063669962 116321.64017418498 1.0270709789229715 1.0769870574257965 1.1330493313239098 0.961808588651303 1.1784223917769243 1.0156678929074694 0.9790485369715352 1.0228122083009457 1.0081660683351115 1.0 16.82775999143488 -6.972623839723003 24.976235904672937 1.0034005664581525 1.0748975271064902 0.29283456235014427 0.054939957979697605 269.56239929522366 245930.36997119954 0.018370277577075392 0.016200712959535103 1.0650651154471102e-07 6.972623839723003 0.07149696064833777 WGEAS(ph)NDEDDPKDK ddPTM_A459_Selumetinib_30min_R1 1 WGEASNDEDDPKDK 14 1 Q5SXM2;A0A1B0GUB4 Q5SXM2 SNAPC4 snRNA-activating protein complex subunit 4 1 WGEAS(1)NDEDDPKDK 116.79 0.015584 0.0 927.93 1479.7 837.99 749.67 961.46 917.66 1361.3 1572.8 622.5 1608.0 True False 949.5489635625311 1306.456036106133 724.19556074958 618.7542075487701 874.4961127595504 908.4291735686154 1258.6160450110824 1531.0842348255937 1056.3370343988627 1814.4024632463836 0.5233397676629966 0.7200475432383301 0.39913722309097144 0.3410236813951831 0.4819747164556179 0.5006767748447754 0.6936807409085681 0.8438503947388452 0.5821955469068492 1.0 10.825278788669797 -7.372629029582661 3.0090980449286264 0.7845710961934038 0.49105380953593214 0.5355693878025021 0.13272746031355334 0.23332509548008823 4.047838603406404 0.06406427102605144 0.04035259398265674 4.240049926363086e-08 7.372629029582661 -0.2935172866574717 WGQPPSPT(ph)PVPRPPDADPNTPSPK ddPTM_A459_Selumetinib_30min_R2 2 WGQPPSPTPVPRPPDADPNTPSPK 24 1 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 WGQPPS(0.264)PT(0.735)PVPRPPDADPNTPSPK;WGQPPS(0.02)PT(0.979)PVPRPPDADPNT(0.001)PSPK 78.419 0.00044177 11466800.0 41135.0 35515.0 34987.0 41995.0 38528.0 37226.0 48824.0 53968.0 42484.0 35599.0 True False 38848.88137645195 38238.88630127619 32735.97451096534 36275.20855458427 33687.76819530984 42353.54359601754 51094.412742920606 54125.037945116615 50981.9871021402 34571.16437269004 1.1237365614199895 1.1060919409322387 0.9469155900582155 1.049290910873698 0.9744470227309426 1.2251118631536546 1.4779488533305907 1.5656122357242162 1.4746968471335062 1.0 15.077281574599473 -7.0150105829445195 3.644936968050712 1.4237598355036343 1.0403722354854632 0.5174088936689609 0.1520359555654969 0.16271637062844793 4.65116182943938 0.057036392865035423 0.046144755691480986 9.660273384229477e-08 7.0150105829445195 -0.38338760001817107 WGQPPSPT(ph)PVPRPPDADPNTPSPKPLEGRPER ddPTM_A459_Selumetinib_30min_R1 1 WGQPPSPTPVPRPPDADPNTPSPKPLEGRPER 32 3 Q14839-2;Q14839;A0A0C4DGG9;A0A2R8Y521;A0A2R8Y212;F5GWX5;A0A2U3TZM0;A0A2R8YFK9;A0A2R8Y5J0;A0A2R8Y425;A0A2R8YER1;A0A2R8Y445;A0A2R8Y8C1;A0A2R8YFD8;A0A2R8YDJ9;A0A2R8YD40;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 Q14839-2 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 WGQPPS(0.054)PT(0.839)PVPRPPDADPNT(0.054)PS(0.054)PKPLEGRPER 40.121 0.022223 25431000.0 2467.2 3442.2 3358.7 3488.0 2454.9 2776.1 2807.7 2446.7 1591.0 2250.2 True False 2524.680959664495 3039.185623764633 2902.606988018492 2878.886277869078 2232.8547284477963 2748.1749544971267 2595.912928507763 2381.805567998334 2699.810797957574 2539.0350888041144 0.994346620413828 1.1969844911422982 1.1431929400336172 1.1338505287160225 0.8794107408336255 1.082369820966719 1.0224013602468323 0.9380750894309872 1.0633215782886973 1.0 11.31006461745526 -6.21145871768666 24.989989183321338 0.9999790204377829 1.1246644479191032 0.39397024166460637 0.07232753171996995 359.3214586694057 179657.92292456902 0.02051309095059817 0.026482248365262546 6.145274434743405e-07 6.21145871768666 0.12468542748132039 WGQS(ph)PPPQQR ddPTM_A459_Selumetinib_30min_R1 1 WGQSPPPQQR 10 0 Q5VV67-2;Q5VV67;E7EVG6 Q5VV67-2 PPRC1 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 1 WGQS(1)PPPQQR 101.35 0.012885 0.0 2499.8 2518.8 2422.1 2678.0 3052.2 2398.1 2845.4 2490.7 1621.4 2606.9 True False 2558.0404762359385 2223.897725041649 2093.1921236429544 2210.3375722859496 2776.129048909678 2373.9772913005863 2630.7691871553184 2424.638545066189 2751.3973776294238 2941.5210083563416 0.8696318907697743 0.7560366622315288 0.7116019629628907 0.7514267503127705 0.9437733203411385 0.8070577380057923 0.8943567561413867 0.8242805467573474 0.9353655370174784 1.0 11.522346624684605 -8.082268371215427 0.3379855949923175 1.0133821389186715 0.762017981931115 0.5037868395504714 0.06345089008619564 1.1733717374036137 0.44046391630666826 0.1090135876041305 0.0869716582820903 8.274306969185251e-09 8.082268371215427 -0.25136415698755643 WGRDDIENIAR ddPTM_A459_Selumetinib_30min_R1 1 WGRDDIENIAR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 109.39 0.026558 2512300.0 1060.7 1653.1 2046.5 2224.2 1372.4 1504.3 1802.4 1229.9 967.62 1438.1 False True 1085.4122462370822 1459.55428349466 1768.5965406198366 1835.7852234049315 1248.266662316899 1489.1681077951166 1666.443516879436 1197.279056721768 1641.980467831369 1622.6941432802398 0.6688951523809321 0.8994635800830609 1.089913677166948 1.1313193130123296 0.7692556650223412 0.9177133682043104 1.026960948728611 0.7378340901024609 1.011885372626133 1.0 10.6641753809399 -4.791191609712721 4.070384211414912 0.9536389899966948 0.6475226216856664 0.3455224824338242 0.11969765081078507 0.25735242635700667 8.084599733464884 0.030861532615659906 0.22509639675873827 1.6173663019643595e-05 4.791191609712721 -0.3061163683110284 WGSDFSPASTVS(ph)APVSR ddPTM_A459_Selumetinib_30min_R1 1 WGSDFSPASTVSAPVSR 17 0 A0A1B0GV45 A0A1B0GV45 1 WGSDFSPAS(0.003)T(0.022)VS(0.974)APVSR 115.8 0.0016469000000000002 2144700.0 517.69 742.25 603.09 668.58 682.07 564.77 577.63 273.37 348.08 456.14 True False 529.7511697506131 655.347024937337 521.1936905362404 551.825053800948 620.3768889292392 559.0889265701314 534.0589040474189 266.1193395690949 590.6663372426607 514.6900121798543 1.0292625798331907 1.2732849082533415 1.0126361075647092 1.072150305508779 1.2053408347711505 1.0862634077592364 1.037632150244245 0.5170478021168626 1.1476156973418343 1.0 9.007559976363464 -7.538151263500137 24.999018089487272 0.8548670086447 1.113505135231467 0.2627453404272141 0.16570282747456525 265.1840271586866 434064.5051143777 0.07228469727034673 0.04175201511284992 2.896334627107648e-08 7.538151263500137 0.2586381265867671 WHQPPPS(ph)PLPLR ddPTM_A459_Selumetinib_30min_R2 4 WHQPPPSPLPLR 12 0 J3QQY0;J3KSZ8;Q68DK7;Q68DK7-2;J3KTC2;Q68DK7-3 J3QQY0 MSL1 Male-specific lethal 1 homolog 1 WHQPPPS(1)PLPLR;WHQPPPS(1)PLPLR;WHQPPPS(1)PLPLR;WHQPPPS(1)PLPLR 91.441 0.015237 27284000.0 59062.0 61496.0 64483.0 72428.0 64890.0 60863.9 55521.7 57792.0 54693.2 64044.0 True False 55779.570483918935 66212.54545919418 60334.23398378196 62563.181454731 56737.9380760397 69247.3497575256 58103.569064161406 57960.16515201934 65633.36825569093 62194.88331370434 0.8968514371603971 1.0645979529413245 0.9700835626535793 1.0059216791061252 0.9122605438434479 1.1133930328038302 0.9342178322144801 0.9319121134076973 1.055285656291744 1.0 15.924508276278605 -4.729762238408654 24.556273930817728 0.9947126768667985 0.8968506213417808 0.19548568941725064 0.06148182635581057 5963.792260753848 4622834.647226416 0.01457366996008621 2.066208461370812 1.8631068457129568e-05 4.729762238408654 -0.0978620555250177 WIDNPTVDDR ddPTM_A459_Selumetinib_30min_R2 2 WIDNPTVDDR 10 0 P18206;P18206-2 P18206 VCL Vinculin 0 ; 201.61 2.0772e-19 0.0 109684.0 88171.0 105061.0 112071.0 118576.0 79118.0 91076.0 95970.0 83236.0 88406.0 False True 103588.20237984086 94933.43218555025 98301.48964176771 96806.73646674145 103679.42279711024 90015.78633830431 95311.2144636704 96249.25681131119 99885.52580815699 85853.48907362664 1.206569511589741 1.1057609097766172 1.1449912019005524 1.1275806902119199 1.2076320242290486 1.0484813990623976 1.110161223406226 1.1210873064083546 1.1634416595753807 1.0 16.389589145890234 -6.764863520627889 24.99994178835241 1.0975477149891595 1.1531075419260264 0.3115708920608671 0.05076277932635777 137.18672973458413 1001605.2212338871 0.017055709946787057 0.015657426763844146 1.7184483339256506e-07 6.764863520627889 0.055559826936866896 WIPFS(ph)YTYR ddPTM_A459_Selumetinib_30min_R1 1 WIPFSYTYR 9 0 Q8NDV1-2;Q8NDV1 Q8NDV1-2 ST6GALNAC3 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 1 WIPFS(0.622)Y(0.377)T(0.002)YR 76.47800000000002 0.037337 21651000.0 2446.9 2676.4 3024.2 3764.8 2725.9 2528.4 2324.0 2657.1 1203.8 1906.7 True False 2503.90800916142 2363.0458437753973 2613.530250741514 3107.3483540485945 2479.3428262967345 2502.9665916035196 2148.698808936866 2586.625076522814 2042.7606779266687 2151.4435178307717 1.1638269786817488 1.098353651486039 1.2147798578401208 1.444308590160726 1.1524089783200875 1.16338940383951 0.9987242477568395 1.2022742196508238 0.9494837586934728 1.0 11.07108925015627 -6.972413498607503 2.365469144158484 1.0542259766106068 1.2225321020320539 0.37889921754850897 0.10600356563614803 0.36723963576706076 4.146241642055731 0.04587935996147979 0.037022901462813965 1.0655810815803809e-07 6.972413498607503 0.16830612542144707 WIS(ph)ENQDSADVDPQEHSFTR ddPTM_A459_Selumetinib_30min_R1 1 WISENQDSADVDPQEHSFTR 20 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 WIS(1)ENQDSADVDPQEHSFTR 147.52 1.4098e-05 6286000.0 1592.6 2166.7 1732.3 1513.1 1607.6 1573.1 1760.8 1777.9 808.31 1295.4 True False 1629.7044813398488 1913.0217567284972 1497.0631748427766 1248.8654894047309 1462.192863844833 1557.2760422605197 1627.9814383717867 1730.744316566902 1371.6430333734047 1461.677208264531 1.11495511603059 1.3087853774499596 1.0242091525941353 0.8544058033767427 1.0003527834855648 1.0654035196385765 1.1137763038015152 1.1840810726068842 0.9384035172868126 1.0 10.513409031347168 -5.281471336183498 24.326813753702517 1.0271398378251833 1.2118702345229433 0.38436197439527453 0.09568673714386447 547.7088484564174 665137.5430022572 0.026631356260355243 0.055566212404055064 5.230324856455215e-06 5.281471336183498 0.18473039669776004 WIS(ph)ENQDSADVDPQEHSFTR ddPTM_A459_Selumetinib_30min_R2 1 WISENQDSADVDPQEHSFTR 20 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 WIS(0.673)ENQDS(0.327)ADVDPQEHSFTR 138.99 5.3097e-05 6704000.0 7803.6 4147.6 7059.4 4973.7 9006.1 8127.5 6593.9 7767.5 6048.3 7573.7 True False 7369.907152285899 4465.707583364021 6605.205889693564 4296.273479888936 7874.673202444455 9246.989350900787 6900.529415564974 7790.102139021156 7258.129003621937 7355.0276021641785 1.0020230447697223 0.607163946203276 0.8980531749126294 0.5841274448276415 1.0706517539277993 1.2572338067337652 0.9382057809728042 1.0591533520185512 0.9868255289057338 1.0 12.844515040340786 -6.2862770521578915 24.42094266357284 1.0595402246966148 0.7699514271691255 0.49030002676158513 0.13930488586611428 454.15913990264187 446537.72486652125 0.041184480796765975 0.046720237364752726 5.172767371321846e-07 6.2862770521578915 -0.28958879752748934 WIS(ph)IMTER ddPTM_A459_Selumetinib_30min_R1 3 WISIMTER 8 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 WIS(0.919)IMT(0.081)ER;WIS(0.99)IMT(0.01)ER;WIS(0.985)IMT(0.015)ER 106.2 0.013829 14417800.0 5753.699999999999 6077.8 6856.599999999999 7679.0 6997.8 5739.5 6296.900000000001 7307.2 3606.2 5130.2 True False 5887.750015248707 5366.208350507434 5925.51138060785 6338.006802682524 6364.850225561938 5681.765841049044 5821.919763336726 7113.389318869264 6119.458013572975 5788.711142379726 1.0171089678570948 0.9270126317447235 1.0236322447023822 1.0948908395655381 1.099528041564251 0.9815251964210608 1.0057367901317231 1.2288381893495148 1.0571365305779068 1.0 12.499026452309609 -5.520700657618284 5.3455925279561125 1.0711234831590615 0.9719840894119451 0.2292493869339034 0.06920361162028214 0.23138213655270298 21.454896355885833 0.01927841139165158 0.03702268114195166 3.0150834885285032e-06 5.520700657618284 -0.09913939374711633 WIS(ph)IMTER ddPTM_A459_Selumetinib_30min_R2 1 WISIMTER 8 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 WIS(0.845)IMT(0.155)ER 101.66 0.01685 1236000.0 5187.7 2818.4 3055.4 5171.8 6301.0 2720.7 4960.3 2816.1 3401.5 4081.7 True False 4899.3884020085 3034.5622174156515 2858.8188904679882 4467.391918147373 5509.41204834529 3095.45172894442 5190.9637786479825 2824.2943847695487 4081.895045850904 3963.850715469789 1.236017386549794 0.7655591583135593 0.7212226432521351 1.1270333417735448 1.389914112265533 0.7809203603111861 1.3095760035535944 0.7125128032060153 1.0297802159704 1.0 11.952686914162527 -4.293135270630824 7.112498880461581 0.9865189809068425 11.983181677747192 0.09925418022763166 0.2292361741198354 6468.18057477841 4201.723097800945 0.057384651211693206 1114557.16194988 5.091722533855848e-05 4.293135270630824 10.99666269684035 WISENQDSADVDPQEHS(ph)FTR ddPTM_A459_Selumetinib_30min_R2 1 WISENQDSADVDPQEHSFTR 20 0 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 WISENQDSADVDPQEHS(0.908)FT(0.092)R 135.12 7.5375e-05 5952300.0 11986.0 11023.0 11787.0 14146.0 16571.0 13827.0 14117.0 13507.0 10631.0 16340.0 True False 11319.86610375964 11868.428655468606 11028.637252715253 12219.29039678889 14489.202833380383 15731.54374099109 14773.468472304823 13546.303133795782 12757.497054958401 15868.22174358144 0.7133670228889024 0.7479369047933354 0.6950140621255335 0.7700478726755561 0.9130955608961755 0.9913866843557543 0.9310097067606561 0.8536749330009297 0.8039651361765662 1.0 13.95385284260218 -6.170578157215727 3.58380977540109 0.9132924670809476 0.7231361549296033 0.7263076634282104 0.05586192978801038 0.1412180499285123 3.4189569762265277 0.01829657040413407 0.024062280778294233 6.751835345744233e-07 6.170578157215727 -0.19015631215134432 WISIMTER ddPTM_A459_Selumetinib_30min_R1 1 WISIMTER 8 0 P07355;H0YN42;P07355-2;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 148.04 0.022485 21490000.0 1746.4 2134.5 2278.5 2075.5 1640.6 1906.2 1624.4 1843.5 1926.0 1948.2 False True 1787.087722097144 1884.5917476978714 1969.0922149046162 1713.0528869602258 1492.208019671455 1887.0253586911217 1501.8702001880572 1794.6043914680702 3268.2813305256363 2198.2704470750027 0.8129517114124996 0.8573065931016317 0.8957461160089156 0.7792730367819835 0.6788100261535028 0.8584136502412518 0.683205381842999 0.8163710674707716 1.486751247952398 1.0 11.10215317261075 -8.201819034508349 10.081482450612231 1.2427954619541401 0.7963355908884707 0.6602721009142841 0.1278578576234974 0.2914324022512851 48.385599518719545 0.08077218126476036 0.030422142651623695 6.283201180054583e-09 8.201819034508349 -0.4464598710656694 WIYEDVER ddPTM_A459_Selumetinib_30min_R2 1 WIYEDVER 8 0 O43852-5;O43852;O43852-3;O43852-13;O43852-14;O43852-11;O43852-10;O43852-6 O43852-5 CALU Calumenin 0 141.52 0.031484 6318800.0 28511.0 28479.0 34840.0 32649.0 35108.0 27488.0 28099.0 34628.0 25489.0 27612.0 False True 26926.472758575932 30663.247725581994 32598.432330923846 28202.149877333548 30697.419170497767 31274.222488780146 29405.65917711221 34728.761747025994 30587.512222164834 26814.769815408225 1.0041657244845532 1.1435208258980605 1.2156894336714474 1.051739398528348 1.1447951775017104 1.1663058345855888 1.0966217267401348 1.2951355535064206 1.140696430837483 1.0 14.710740248514378 -6.503010242404806 24.06966321221353 1.1555076189646234 1.1125681862415384 0.022604294603876363 0.08632809127065871 1655.7115124914653 2005812.2744937083 0.0265103067573082 0.029622540488834552 3.140434628965477e-07 6.503010242404806 -0.04293943272308498 WKEPGSGGPQNLS(ph)GPGGR ddPTM_A459_Selumetinib_30min_R1 2 WKEPGSGGPQNLSGPGGR 18 1 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 WKEPGSGGPQNLS(1)GPGGR;WKEPGSGGPQNLS(1)GPGGR 138.77 0.00018258 168985000.0 6494.0 8092.5 8734.400000000001 8679.3 7844.6 7020.799999999999 7366.9 6823.5 3938.6 5801.0 True False 6645.297564875666 7145.026337898819 7548.316454624919 7163.623185639073 7135.057315076622 6950.1771263763585 6811.208801874782 6642.518614148295 6683.516536037524 6545.614856525048 1.0152289296782024 1.09157451125867 1.1531867700862846 1.0944156267455851 1.0900515034067402 1.0618066107950148 1.0405758589790803 1.0148043781596234 1.021067796155927 1.0 12.676313001476773 -7.2599047110330135 1.3839358770495505 1.0112580291845148 1.0935518719006714 0.5289590161255917 0.03166160039687879 0.35929470257937324 1.3426623094040964 0.020448887715896633 0.011976027475404171 5.496614623742567e-08 7.2599047110330135 0.08229384271615658 WKEPGSGGPQNLS(ph)GPGGR ddPTM_A459_Selumetinib_30min_R2 2 WKEPGSGGPQNLSGPGGR 18 1 Q9H0W8-2;Q9H0W8;M0QZH1;M0QX70;M0QYR7;M0R2N0;M0QZC7 Q9H0W8-2 SMG9 Protein SMG9 1 WKEPGSGGPQNLS(1)GPGGR;WKEPGSGGPQNLS(1)GPGGR 113.51 0.00063803 103455000.0 245022.0 237800.0 266728.0 264540.0 284770.0 256963.0 227152.0 220903.0 176921.0 258659.0 True False 231404.65814078026 256038.49535248423 249567.01087148787 228509.19564304588 248994.64672389944 292357.32077213423 237715.01809314894 221545.79115753956 212310.14358576798 251190.84259320877 0.9212304706327561 1.0192986842562808 0.9935354660824535 0.9097035277400829 0.9912568633209852 1.1638852664927462 0.9463522461211563 0.8819819579025103 0.8452145046131073 1.0 17.93842434477233 -7.519607280409546 24.39502388639616 0.9009923133398511 1.0008651151030812 0.23354130182177257 0.07415429837681685 140.35824845701967 1046676.4097259991 0.03503458612006125 0.020772708002017345 3.0226838080604824e-08 7.519607280409546 0.0998728017632301 WLAES(ph)PVGLPPEEEDKLTR ddPTM_A459_Selumetinib_30min_R1 4 WLAESPVGLPPEEEDKLTR 19 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 WLAES(1)PVGLPPEEEDKLTR;WLAES(1)PVGLPPEEEDKLTR;WLAES(1)PVGLPPEEEDKLTR;WLAES(1)PVGLPPEEEDKLTR 140.63 6.3548e-05 53770000.0 12703.900000000001 14941.400000000001 16464.2 16968.0 14319.900000000001 14175.0 13882.600000000002 13976.1 7687.6 12208.3 True False 12999.876152513696 13192.053941931585 14228.452071377038 14004.857328808059 13024.667573383693 14032.412369870231 12835.424305054627 13605.408427229133 13045.295719911159 13775.354223912203 0.9437053988744348 0.9576562408124442 1.0328919198809652 1.0166604140383895 0.9455050927673847 1.018660728557659 0.9317672777353353 0.9876630543272661 0.9470025603600263 1.0 13.749801796749582 -9.156644802599986 12.386559902990985 0.9999999984089089 0.9775100821612732 0.04019139028176599 0.03461317525892638 3840397.4358186014 258088.72729958026 0.033497711454033026 0.008374427867720736 6.971964986526464e-10 9.156644802599986 -0.022489916247635633 WLAES(ph)PVGLPPEEEDKLTR ddPTM_A459_Selumetinib_30min_R2 3 WLAESPVGLPPEEEDKLTR 19 1 E9PGC8;P78559;P78559-2 E9PGC8 MAP1A Microtubule-associated protein 1A;MAP1A heavy chain;MAP1 light chain LC2 1 WLAES(1)PVGLPPEEEDKLTR;WLAES(1)PVGLPPEEEDKLTR;WLAES(1)PVGLPPEEEDKLTR 83.251 0.0025589 11050000.0 33188.1 29618.9 31813.3 38229.8 31304.5 26758.8 28279.0 29189.5 22506.4 30379.3 True False 31343.638264490706 31890.574390225815 29766.466913702054 33022.83528991658 27371.748844219186 30444.581807798713 29594.02953377545 29274.436612418147 27008.308881357887 29502.170674099354 1.0624180373279455 1.0809568808515944 1.008958535374305 1.1193357822618828 0.927787624395024 1.0319437896319514 1.0031136305423365 0.99228076929671 0.9154685321195404 1.0 14.848533486754384 -6.327795729869075 0.767589255461282 0.9731946417211638 1.0729608757424525 0.37257303959650057 0.04765623105505009 0.770313782264984 0.9904560532587283 0.02714962039028627 0.043602552557315634 4.701151749828588e-07 6.327795729869075 0.0997662340212887 WLDDLLAS(ph)PPPSGGGAR ddPTM_A459_Selumetinib_30min_R1 4 WLDDLLASPPPSGGGAR 17 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 WLDDLLAS(1)PPPSGGGAR;WLDDLLAS(0.997)PPPS(0.003)GGGAR;WLDDLLAS(1)PPPSGGGAR;WLDDLLAS(1)PPPSGGGAR 249.86 1.6428e-30 423245000.0 21025.4 26422.6 29391.399999999998 28619.800000000003 25770.6 23452.399999999998 25284.7 22836.1 13540.2 19799.100000000002 True False 21515.250911693383 23329.029708466518 25400.209315403783 23621.88919018274 23439.653780168966 23216.490149075467 23377.45472217123 22230.412445893144 22976.730462919648 22340.507344565605 0.963060085424919 1.0442479818678503 1.1369575866674513 1.057356882091079 1.0491997078961026 1.0392105152760978 1.0464155697814923 0.9950719606777756 1.0284784543404206 1.0 14.447374328807458 -7.679261074743895 6.113898005832361 1.0090052612043854 1.0517599850249812 0.17103302497671957 0.04005838101927731 0.3722703869894535 21.648967925437965 0.02037515386097687 0.01151795476229507 2.0928539651277956e-08 7.679261074743895 0.042754723820595864 WLDDLLAS(ph)PPPSGGGAR ddPTM_A459_Selumetinib_30min_R2 7 WLDDLLASPPPSGGGAR 17 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 WLDDLLAS(0.992)PPPS(0.008)GGGAR;WLDDLLAS(1)PPPSGGGAR;WLDDLLAS(0.998)PPPS(0.002)GGGAR;WLDDLLAS(0.999)PPPS(0.001)GGGAR;WLDDLLAS(1)PPPSGGGAR;WLDDLLAS(0.984)PPPS(0.016)GGGAR;WLDDLLAS(1)PPPSGGGAR 226.67 3.4353e-16 291037400.0 359707.7 352119.1 424538.14 434031.36 444989.17000000004 303274.4 334716.73 354067.3 309299.4 406732.0 True False 339716.5860580126 379125.50272864144 397223.81827457825 374915.54002214136 389085.6522109463 345047.6957491015 350281.72117361776 355097.5772240033 371167.92254730506 394988.59034335066 0.8600668332285449 0.9598391244645321 1.0056589683496544 0.9491806831590744 0.9850554211521069 0.8735637033190322 0.8868147833564745 0.8990071761701487 0.9396927699219386 1.0 18.59145145458021 -6.754978987637267 24.99800068218082 0.91144107835223 0.9552267658861011 0.08524896935447401 0.048355968222615196 293.1575798872934 1134350.2775251782 0.016073371107795113 0.015709373397343063 1.7580086692006356e-07 6.754978987637267 0.04378568753387113 WLDES(ph)DAEMELR ddPTM_A459_Selumetinib_30min_R1 14 WLDESDAEMELR 12 0 H3BPZ1;H3BS72;Q9P035 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 1 WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR 269.14 1.0962e-33 224223550.0 18408.99 28003.28 19938.559999999998 16475.51 25347.92 25883.860000000004 29715.899999999994 29461.95 13274.580000000002 27126.640000000003 True False 18837.883649340998 24724.64295922832 17231.013066670424 13598.371462125797 23055.205111538755 25623.491869064495 27474.40573859165 28680.523380099097 22525.99272303687 30608.60847984944 0.6154439742578477 0.8077676244415125 0.5629466324159791 0.44426624199783565 0.7532261757902743 0.8371335105264 0.8976038801854997 0.9370084039913261 0.7359365172665854 1.0 14.901649838499525 -6.602049488835415 3.307510144879915 0.8795781266297853 0.6167413800088997 0.5956757168813711 0.10566266898526944 0.18610075885313784 4.08938269103587 0.03786069718997653 0.03833435142998705 2.5000604579379687e-07 6.602049488835415 -0.26283674662088563 WLDES(ph)DAEMELR ddPTM_A459_Selumetinib_30min_R2 18 WLDESDAEMELR 12 0 H3BPZ1;H3BS72;Q9P035 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 1 WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR;WLDES(1)DAEMELR 231.07 9.0132e-20 53088500.0 621649.7999999999 180924.5 490558.50000000006 515726.89999999997 265125.31999999995 292850.6 773197.7 500078.30000000005 505210.29999999993 343999.49999999994 True False 587100.9927773199 194800.8273860412 458996.50018971064 445484.00654147496 231817.90705116684 333188.11191693693 809152.9251121769 501533.4450605806 606266.4767552101 334067.3406169612 1.757433072305278 0.5831184426058523 1.3739640018148083 1.3335155891586037 0.6939256816396407 0.9973681093805803 2.4221252027145774 1.5012944519938412 1.8148031939774387 1.0 18.34977942199133 -7.198876191200456 24.999951920032856 1.7263369425500925 1.1001131598467722 0.2645011955755555 0.45546978303434493 264.02228512388484 105501.86603470499 0.16514197742802975 0.12791840436020152 6.325921652348808e-08 7.198876191200456 -0.6262237827033204 WLHNEDQMAVEK ddPTM_A459_Selumetinib_30min_R1 3 WLHNEDQMAVEK 12 0 P37837 P37837 TALDO1 Transaldolase 0 ;; 249.23 3.7002e-16 60566000.0 14465.099999999999 16269.300000000001 17128.899999999998 18273.7 16365.3 13673.900000000001 15179.4 15088.5 8392.9 12330.199999999999 False True 14802.108685815052 14364.482792607627 14802.889462312785 15082.541334832618 14885.061504528383 13536.352980907843 14034.405636994947 14688.303965644694 14242.138306837294 13912.90127631876 1.0639124357915064 1.032457753226317 1.063968554675859 1.0840687384524685 1.0698747305757386 0.9729353146455626 1.0087332151837374 1.0557326379254737 1.023664153434261 1.0 13.764135677970694 -6.727822589380307 24.987510749284016 1.0154788210706351 1.0624078974181435 0.549645578689266 0.022823405677976968 168.53648623559806 125273.49037581641 0.008147580176930716 0.008147105996752238 1.8714464758284897e-07 6.727822589380307 0.046929076347508314 WLIS(ph)PVK ddPTM_A459_Selumetinib_30min_R1 1 WLISPVK 7 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 WLIS(1)PVK 88.948 0.031607 151330000.0 11988.0 12088.0 14761.0 14333.0 11543.0 11655.0 12095.0 10261.0 6961.8 9737.1 True False 12267.29707541261 10672.731340441254 12756.537276369121 11830.010613732069 10498.937688082175 11537.761281893303 11182.66441225964 9988.844947574647 11813.666130245792 10986.951632385806 1.1165332738202634 0.9714005938627839 1.1610624769446674 1.0767327471308066 0.9555824071469349 1.050133073115922 1.0178132011883023 0.9091552672472791 1.0752451203501354 1.0 13.423503540642347 -6.230528874935013 19.180074113231655 1.0000445328873158 1.0792612037673306 0.2856950886615932 0.0619987249890306 53.89790589300117 33442.23582834584 0.01772896022581121 0.022874947258762945 5.881270100455657e-07 6.230528874935013 0.07921667088001483 WLIS(ph)PVK ddPTM_A459_Selumetinib_30min_R2 2 WLISPVK 7 0 C9JWC4;Q8NCD3-3;Q8NCD3-2;Q8NCD3 C9JWC4 HJURP Holliday junction recognition protein 1 WLIS(1)PVK;WLIS(1)PVK 86.13600000000002 0.035301 145017000.0 682118.0 667184.0 651907.0 665124.0 684605.0 574506.0 637788.0 595342.0 467971.0 631494.0 True False 644208.6122947035 718354.8674653166 609964.0133626751 574532.9637971026 598598.7994536462 653638.9866537817 667446.4057529459 597074.3466558265 561578.2762022337 613261.127401543 1.0504637967586312 1.171368663963861 0.9946236376454544 0.9368488203898786 0.9760912158087979 1.0658412174652654 1.0883559644176244 0.9736054022952643 0.9157245602402759 1.0 19.22614198063735 -5.282119569454771 23.81527813326111 0.9962148092697836 1.1109162200587346 0.4091481077204292 0.05619860370965949 398.96952380098435 459452.69974160695 0.015739503772248833 0.03283720408576523 5.222523832813052e-06 5.282119569454771 0.11470141078895102 WLNSGRGDEASEEGQNGS(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 WLNSGRGDEASEEGQNGSSPK 21 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 WLNSGRGDEASEEGQNGS(0.645)S(0.355)PK 150.95 8.9571e-07 33619000.0 694.19 589.35 2340.5 2406.7 1291.5 1158.4 791.02 718.63 921.02 508.6 True False 710.3632763413975 520.3486280186183 2022.6729554462368 1986.4150243542174 1174.684053032844 1146.7475477430469 731.3527245461444 699.5695979607807 1562.9036713607077 573.8837641835265 1.2378173432943211 0.9067143217737246 3.5245342030610076 3.46135428169905 2.046902397916912 1.9982226703599861 1.274391732595278 1.219009216885704 2.7233801841114555 1.0 9.164614749293612 -6.9357786890760185 2.9586653092622566 1.5776306568195009 2.303035757164906 0.11282107523382734 0.8866375956657344 0.642800801373213 11.4243369260939 0.3770894812695136 0.31771829061678586 1.1593680047841423e-07 6.9357786890760185 0.725405100345405 WLNSGRGDEASEEGQNGS(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 WLNSGRGDEASEEGQNGSSPK 21 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 WLNSGRGDEASEEGQNGS(0.5)S(0.5)PK 110.37 6.0353e-05 9955800.0 23118.0 42162.0 26998.0 30395.0 21072.0 9695.0 6343.3 7867.4 2239.3 21929.0 True False 21833.194108686428 45395.68982780252 25260.978073199847 26255.148565700427 18424.746973929847 11030.398247552515 6638.276019010498 7890.292831481816 2687.222571269715 21295.85279161549 1.0252322047080686 2.1316680891819235 1.1861923690205771 1.2328761295738055 0.8651800495720913 0.5179599218442831 0.3117168438365657 0.3705084228694682 0.1261852529487674 1.0 14.378284883262552 -6.322818575307326 1.2493700521501996 0.3902077579515029 1.5433885008669164 0.6253754211456534 0.3409152801937227 0.26079043704944815 0.8346264224821286 0.13318425444451076 0.18104036541227833 4.7553383671515623e-07 6.322818575307326 1.1531807429154135 WLPS(ph)SPSGVAK ddPTM_A459_Selumetinib_30min_R1 1 WLPSSPSGVAK 11 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 WLPS(0.598)S(0.379)PS(0.022)GVAK 149.23 0.00063496 67755000.0 5247.8 8010.8 8126.7 9561.3 7108.5 6535.5 6910.0 5951.6 3269.0 5241.5 True False 5370.063529558745 7072.891811880114 7023.138776767761 7891.598442829589 6465.537430107604 6469.758803759217 6388.773136727082 5793.744234478634 5547.254241686561 5914.297581533535 0.9079799343079937 1.1958971821039421 1.187484850051578 1.3343255617488483 1.0932046182957094 1.0939183756935096 1.0802251744442184 0.9796166247313444 0.9379396564364618 1.0 12.529991120038108 -7.452652461583408 1.3589445146914183 0.9623281208901724 1.1565765962762304 0.33688690865943305 0.10179699846840161 0.5010906091301374 1.768857055692592 0.07265557059181313 0.03595640216698067 3.526529640282769e-08 7.452652461583408 0.19424847538605805 WLPS(ph)SPSGVAK ddPTM_A459_Selumetinib_30min_R2 1 WLPSSPSGVAK 11 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 WLPS(0.609)S(0.371)PS(0.02)GVAK 122.18 0.0042268 42668000.0 53978.0 46047.0 57101.0 54187.0 51027.0 37255.0 38664.0 40825.0 37123.0 45047.0 True False 50978.118851054394 49578.65683555866 53427.18382686805 46806.63712221117 44616.53207283212 42386.538082781735 40461.95261126254 40943.79399105745 44548.63730328477 43746.376063838004 1.165310671143669 1.1333203180809708 1.2212939364143691 1.069954618730187 1.0198909278273545 0.9689154141803222 0.9249212449556373 0.9359356745644298 1.0183389188232654 1.0 15.416875889036676 -6.16694916849191 1.9014342918575762 0.9648326403627469 1.1693196459159116 0.8513865318849707 0.03645823785921432 0.11867675173033233 0.8458443974536635 0.012338026777663364 0.01738717718269863 6.808490432391576e-07 6.16694916849191 0.2044870055531648 WLPSS(ph)PSGVAK ddPTM_A459_Selumetinib_30min_R1 1 WLPSSPSGVAK 11 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 WLPS(0.381)S(0.612)PS(0.007)GVAK 155.02 0.00053276 68916000.0 4752.1 8596.7 8415.1 9028.2 6928.4 6846.2 7286.0 5360.4 3637.7 4898.2 True False 4862.814684023041 7590.194367502601 7272.375640835565 7451.594350303208 6301.727443308367 6777.333443852247 6736.411154007747 5218.224778966877 6172.911212904007 5526.931682508355 0.8798398394199239 1.3733106909072288 1.315807044232371 1.3482334825823936 1.1401855143699509 1.226237962249681 1.2188338016420857 0.9441449756800009 1.1168785082761288 1.0 12.432263064408742 -7.744797611285547 23.795423737181995 1.0228838731835195 1.2273508509598559 0.29385574360463196 0.13701654913763722 155.01534638778702 221651.38821946684 0.06358977580978319 0.036558951205381156 1.7997094153447803e-08 7.744797611285547 0.20446697777633638 WLPSS(ph)PSGVAK ddPTM_A459_Selumetinib_30min_R2 1 WLPSSPSGVAK 11 0 Q8IWI9;Q8IWI9-3;H3BP52;H3BTF4 Q8IWI9 MGA MAX gene-associated protein 1 WLPS(0.283)S(0.715)PS(0.002)GVAK 166.7 0.00057945 53160000.0 165420.0 157080.0 178170.0 159430.0 176530.0 126120.0 129070.0 148560.0 127110.0 143040.0 True False 156226.61862872704 169127.53090819312 166706.73617682856 137715.3589679099 154352.72320177642 143491.8851966296 135072.01074735317 148992.28500456805 152535.5517501419 138910.06353744757 1.124660191279887 1.2175326005995202 1.2001055354199557 0.9913994383192001 1.1111702008556479 1.0329840872756266 0.9723702322757938 1.0725809290584805 1.098088560797621 1.0 17.083791595639816 -5.752511373927723 24.999999399991182 1.042703573333092 1.1844427989136954 0.6435457009409524 0.048019811542021625 119.34226812056424 334175.9881807966 0.013122487129009826 0.02230624384392524 1.768025913525725e-06 5.752511373927723 0.14173922558060337 WLTS(ph)PVR ddPTM_A459_Selumetinib_30min_R2 1 WLTSPVR 7 0 E7EPJ7;O75962-5;O75962-4;O75962;E7EWP2;O75962-2;C9J1B4;A0A1W2PRD7;O60229-5;H7BXZ5;O60229-6;O60229-4;O60229 E7EPJ7;H7BXZ5 TRIO;KALRN Triple functional domain protein;Kalirin 1 WLT(0.492)S(0.508)PVR 82.426 0.041183 7741800.0 61220.0 54614.0 63357.0 64307.0 72158.0 55472.0 56882.0 60710.0 54890.0 69506.0 True False 57817.637483077364 58802.718188311956 59280.67959788584 55548.275664237444 63092.866939295214 63112.76447532061 59527.125709544714 60886.65604891843 65869.53375474238 67499.18118172405 0.8565679830606887 0.8711619483205415 0.8782429439890237 0.822947400127538 0.9347204786000888 0.9350152604874694 0.8818940417852382 0.9020354763266962 0.9758567822831175 1.0 16.042582380790975 -8.059301917265303 0.25977127115660414 1.0219495051729544 0.8379741790527746 0.6595196718244887 0.03049050962025418 1.2734743111316735 0.3517380690248763 0.0895548788185565 0.07982728073859234 8.723646981528444e-09 8.059301917265303 -0.18397532612017975 WNRVRMPVGS(ph)PLLR ddPTM_A459_Selumetinib_30min_R1 1 WNRVRMPVGSPLLR 14 2 Q5QPA5;Q9NVS2;Q9NVS2-2 Q5QPA5 MRPS18A 28S ribosomal protein S18a, mitochondrial 1 WNRVRMPVGS(1)PLLR 65.234 0.028423 109430000.0 2571.6 2909.4 3128.4 3397.1 1393.6 1963.1 1200.0 1868.8 1977.5 1999.7 True False 2631.513276537457 2568.7660954566354 2703.580463071144 2803.860256464748 1267.5491260600643 1943.3529963521885 1109.4830338744578 1819.2333532820871 3355.6730691144576 2256.3809737274833 1.1662539735877424 1.138445202900776 1.1981932548406924 1.2426360127619953 0.5617620166181891 0.8612698914677601 0.49170908937492963 0.8062616085069891 1.4871925921139868 1.0 11.13979496166488 -6.235261851117038 24.838879771110225 0.83919127973957 1.1838017414006758 0.26786807303586235 0.255163014773287 929.3969626215281 881870.0599006485 0.07687727429280519 0.09921583983280499 5.817523534554555e-07 6.235261851117038 0.34461046166110587 WNS(ph)FQLSHQPR ddPTM_A459_Selumetinib_30min_R2 2 WNSFQLSHQPR 11 0 H3BRG5;Q9Y3M8-5;Q9Y3M8-3;Q9Y3M8-4;Q9Y3M8-2;Q9Y3M8 H3BRG5 STARD13 StAR-related lipid transfer protein 13 1 WNS(1)FQLSHQPR;WNS(1)FQLSHQPR 115.83 0.004012 6076200.0 25889.0 26187.0 32361.0 32153.0 35258.0 27269.0 31385.0 39088.0 28492.0 28395.0 True False 24450.19302187832 28195.45869552358 30278.92849199274 27773.705932981262 30828.57482948076 31025.057226664227 32844.464688197666 39201.73960863326 34191.19613299544 27575.1625709299 0.8866744832051883 1.022494740438905 1.098050769931387 1.0072000794751677 1.1179834298413402 1.1251087694174196 1.1910887054142967 1.4216322209450998 1.239927273141093 1.0 14.751081770881356 -6.688917424007685 1.089705170248539 1.2469408448921457 0.9983289162466431 0.40647967649347083 0.10927636633099296 0.4496290818809254 1.1404193957298456 0.05669724719814425 0.05511496440945694 2.046833781118906e-07 6.688917424007685 -0.24861192864550263 WNSVS(ph)PASAGK ddPTM_A459_Selumetinib_30min_R2 2 WNSVSPASAGK 11 0 E5RJU9;Q86UE4;H0YB56;H0YBE0 E5RJU9 MTDH Protein LYRIC 1 WNS(0.004)VS(0.796)PAS(0.2)AGK;WNS(0.374)VS(0.626)PAS(0.001)AGK 117.48 0.0055868 16703000.0 109573.0 45716.0 102775.0 99749.0 59750.0 53056.0 151006.0 99595.0 105877.0 72771.0 True False 103483.37131547263 49222.27019989136 96162.56839295919 86163.01412337742 52243.67082822266 60363.98240558499 158028.07821271228 99884.80496116004 127055.35845055284 70669.9121482352 1.4643200786553807 0.6965095710978687 1.3607285684925052 1.2192319404988692 0.7392632768332557 0.8541680691348138 2.2361436912676087 1.4133993084871042 1.7978706154897308 1.0 16.108808495098202 -7.233715903800867 24.997534106976197 1.646303539756273 1.0462907887704254 0.3449083086999509 0.37415092967130414 747.1952312576706 673727.3283409794 0.1363427263058319 0.10558766743880607 5.8382689305968316e-08 7.233715903800867 -0.6000127509858477 WPCTS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 WPCTSPR 7 0 Q9Y4B5;Q9Y4B5-2;Q9Y4B5-3;Q9Y4B5-4 Q9Y4B5;Q9Y4B5-4 MTCL1 Microtubule cross-linking factor 1 1 WPCT(0.014)S(0.986)PR;WPCT(0.017)S(0.983)PR 88.37 0.032367 36197000.0 15446.400000000001 17451.0 17434.0 18938.5 17518.3 14798.3 16183.5 15071.6 9251.4 12913.3 True False 15806.271066537643 15407.8288072502 15066.558558107115 15631.246494674173 15933.772858107077 14649.442537781346 14962.7655655894 14671.852208543618 15698.950104478137 14570.847841193736 1.0847873259544445 1.057442159521439 1.0340207187883699 1.0727753570030805 1.0935377976468994 1.0053939686588047 1.0268973863887083 1.0069319485352342 1.0774218683483268 1.0 13.830797206210502 -6.768724686722704 24.99978795594816 1.0239853031092006 1.0662182404321938 0.4452520529200792 0.025146700138634237 174.72676139682153 599578.7436064506 0.008750195506874317 0.007877208613552336 1.7032379036605637e-07 6.768724686722704 0.04223293732299327 WQELS(ph)PETSGK ddPTM_A459_Selumetinib_30min_R2 1 WQELSPETSGK 11 0 Q9NWF9-3;Q9NWF9;Q9NWF9-1 Q9NWF9-3 RNF216 E3 ubiquitin-protein ligase RNF216 1 WQELS(0.883)PET(0.089)S(0.028)GK 93.228 0.023894 2478300.0 27413.0 27554.0 26047.0 29526.0 31882.0 25016.0 21445.0 22814.0 22065.0 35161.0 True False 25889.495202933696 29667.303199925773 24371.164377829333 25504.507864809042 27876.698131303703 28461.72692736194 22442.234992461334 22880.384962938973 26478.61654761142 34145.810570750735 0.7582041477472089 0.8688416735181783 0.7137380536722606 0.7469293432634508 0.8164017097659076 0.8335349623166428 0.6572471005179572 0.6700788348699588 0.77545725537097 1.0 15.059420961298567 WQELSPET(ph)SGK ddPTM_A459_Selumetinib_30min_R2 1 WQELSPETSGK 11 0 Q9NWF9-3;Q9NWF9;Q9NWF9-1 Q9NWF9-3 RNF216 E3 ubiquitin-protein ligase RNF216 1 WQELS(0.285)PET(0.655)S(0.06)GK 118.73 0.012218 2733500.0 23685.0 21519.0 22308.0 22149.0 26363.0 23960.0 22003.0 21598.0 18860.0 21084.0 True False 22368.682518567253 23169.438105509293 20872.727567113932 19132.267990843848 23051.044251789703 27260.27251277548 23026.18309811736 21660.84660425861 22632.526992429255 20475.250137189152 1.092474200251115 1.1315826644494416 1.0194125799324347 0.9344094876816157 1.1258003734920015 1.3313767758696489 1.1245861683660192 1.0579038819611812 1.1053602198159156 1.0 14.321593456298665 -3.8653606400869696 12.616112816688304 1.0970497496472245 1.093119517254131 0.0 0.1006016737007235 0.0 0.0 0.025563212242073845 7956081.331490864 0.00013634504509864827 3.8653606400869696 -0.003930232393093425 WQHWHEECER ddPTM_A459_Selumetinib_30min_R1 2 WQHWHEECER 10 0 J3QLV0;J3QLD4;J3QL54;J3KT10;Q9BW27-2;Q9BW27-3;Q9BW27 J3QLV0 NUP85 Nuclear pore complex protein Nup85 0 ; 100.88 0.0095631 9795000.0 3482.4 3790.2999999999997 3213.9 3937.5 4321.5 3343.5 3349.5 2352.15 1684.0700000000002 2103.98 False True 3563.533144429168 3346.5299139373333 2777.470032689024 3249.8895410290957 3930.621088022792 3309.8674256551076 3096.8445183020776 2289.763341140016 2857.743790393724 2374.0463275007014 1.5010377443563663 1.4096312591593032 1.169930847816702 1.3689242300719742 1.6556631783006477 1.3941882208927239 1.3044583344598455 0.9644981711669397 1.2037439022524212 1.0 11.213132372886804 -7.595492636666858 4.292431557327992 1.064895220504162 1.4100753155129706 0.6128511981192729 0.12770379084020303 0.1592528741106184 5.69353195466194 0.06730376792088195 0.03757015635763747 2.5380920181905823e-08 7.595492636666858 0.34518009500880864 WQHWHEECER ddPTM_A459_Selumetinib_30min_R2 1 WQHWHEECER 10 0 J3QLV0;J3QLD4;J3QL54;J3KT10;Q9BW27-2;Q9BW27-3;Q9BW27 J3QLV0 NUP85 Nuclear pore complex protein Nup85 0 115.7 0.0037032 1477700.0 4125.7 3126.9 2852.1 3432.9 5261.9 3372.0 3438.6 3285.2 3519.3 3836.5 False True 3896.410110485665 3366.7231754318063 2668.598991131685 2965.3330979171888 4600.853080017155 3836.4623920316767 3598.5017134566388 3294.759388105862 4223.258337457912 3725.730276575895 1.045811108491362 0.9036411456295673 0.7162619924231985 0.7959065412116887 1.2348862473870585 1.029720915695902 0.9658513757909001 0.8843257948167644 1.1335384002459958 1.0 11.863307519131796 -6.221502962359291 24.99988784907693 1.031243486173976 0.8574832317326253 0.3439626654170127 0.11836687331471055 661.9550242894538 414378.54374396213 0.036790489738146144 0.04749564903093557 6.00477912983086e-07 6.221502962359291 -0.1737602544413508 WQRPS(ph)SPPPFLPAASEEAEPAEGLR ddPTM_A459_Selumetinib_30min_R1 2 WQRPSSPPPFLPAASEEAEPAEGLR 25 1 H3BLU1;Q4KMQ1;Q4KMQ1-2;Q4KMQ1-4;Q4KMQ1-3 H3BLU1 TPRN Taperin 1 WQRPS(0.498)S(0.498)PPPFLPAAS(0.004)EEAEPAEGLR;WQRPS(0.565)S(0.435)PPPFLPAASEEAEPAEGLR 132.48 2.9775e-08 72736000.0 2595.0 3192.2 2623.0 2640.3 3295.9 2945.2 2825.3 2591.2 1749.33 2401.3 True False 2655.458451008985 2818.455739986481 2266.8110071076617 2179.2211695693027 2997.786426938408 2915.573962027639 2612.1853463379216 2522.472958596183 2968.4852439919064 2709.530245642751 0.9800438490322372 1.040200877815959 0.8366066445476905 0.8042800677622075 1.1063860356455542 1.0760440732175738 0.9640731453500577 0.9309632039179564 1.0955719164846327 1.0 11.403827036231595 -6.272443139998594 24.96721215597896 1.024509772482403 0.9185858411121257 0.3188937750846075 0.08109705676651013 1037.079233020481 2353098.4109227196 0.027317525949695286 0.031266900235309446 5.340191854548539e-07 6.272443139998594 -0.10592393137027734 WQRPS(ph)SPPPFLPAASEEAEPAEGLR ddPTM_A459_Selumetinib_30min_R2 3 WQRPSSPPPFLPAASEEAEPAEGLR 25 1 H3BLU1;Q4KMQ1;Q4KMQ1-2;Q4KMQ1-4;Q4KMQ1-3 H3BLU1 TPRN Taperin 1 WQRPS(0.5)S(0.5)PPPFLPAASEEAEPAEGLR;WQRPS(0.5)S(0.5)PPPFLPAASEEAEPAEGLR;WQRPS(0.5)S(0.5)PPPFLPAASEEAEPAEGLR 124.1 4.2226e-08 40711000.0 46844.7 52161.0 52012.0 53978.0 62814.6 48486.9 40158.4 51495.2 42534.9 50198.0 True False 44241.259108192025 56161.58097595013 48665.60454638377 46626.103282756274 54923.268378351095 55165.53035474513 42025.84517235996 51645.0425065107 51043.068524405026 48748.653309932735 0.9075380775529586 1.1520642553731217 0.9982963885582448 0.956459309477089 1.1266622696048971 1.1316318833264043 0.8620924337164617 1.0594147530222708 1.0470662276532015 1.0 15.573074744259547 -10.165887289170904 7.287169413513744 0.9999999999960355 1.0297146496450738 0.006639520396476528 0.09236684307302749 0.0 0.0 0.08723454889582057 0.021157485683574843 6.825158019422474e-11 10.165887289170904 0.02971464964903825 WQRPS(ph)SPPPFLPAASEEAEPAEGLRVPGLAK ddPTM_A459_Selumetinib_30min_R1 1 WQRPSSPPPFLPAASEEAEPAEGLRVPGLAK 31 2 H3BLU1;Q4KMQ1;Q4KMQ1-2;Q4KMQ1-4;Q4KMQ1-3 H3BLU1 TPRN Taperin 1 WQRPS(0.499)S(0.499)PPPFLPAAS(0.003)EEAEPAEGLRVPGLAK 55.68600000000001 0.0013456 19693000.0 2236.6 2236.2 3960.2 4656.4 3589.4 3454.6 2898.2 2718.5 1827.7 1724.4 True False 2288.7084283339873 1974.3846644188247 3422.4265918214865 3843.2471514534323 3264.739403760039 3419.849860525835 2679.586440645795 2646.396549067507 3101.4734100735745 1945.7435370783987 1.1762641811317858 1.0147198882045019 1.7589299548492288 1.9752074609093657 1.677887831333701 1.757605663519694 1.377152944148686 1.360095253376076 1.5939785233620996 1.0 10.926105849782 -9.85524429631283 0.7207308143577058 0.9667394298100747 1.5393496374612938 0.23714726799004604 0.2782854874924691 17.473966628592315 7.501787121893257 1.9820879548429204 0.11124510433037268 1.3955831065114278e-10 9.85524429631283 0.5726102076512192 WQS(ph)PVTK ddPTM_A459_Selumetinib_30min_R1 1 WQSPVTK 7 0 A9Z1X7;M0R088 A9Z1X7 SRRM1 1 WQS(0.87)PVT(0.13)K 94.409 0.024453 504720000.0 7583.9 8759.0 9153.5 9356.3 8203.0 6817.7 8581.8 7780.6 4115.8 6247.1 True False 7760.590114299433 7733.492208051375 7910.5049765764325 7722.397844502999 7461.040098357282 6749.120127976318 7934.467916753184 7574.233213049346 6984.211993861591 7048.976136907017 1.1009528140784233 1.0971085811399433 1.1222204222197072 1.095534683976313 1.0584572785390465 0.957461054895517 1.125619914530553 1.0745153715859797 0.9908122624069708 1.0 12.783198006077415 -6.307329182520165 3.8056869274292264 1.0377116361645866 1.105519319592105 0.3752771931052681 0.04440091286733852 0.28143566592531577 8.598916601753022 0.014381149048721474 0.01703796169387667 4.928001342633034e-07 6.307329182520165 0.0678076834275183 WQS(ph)PVTK ddPTM_A459_Selumetinib_30min_R2 4 WQSPVTK 7 0 A9Z1X7;M0R088 A9Z1X7 SRRM1 1 WQS(0.983)PVT(0.017)K;WQS(0.996)PVT(0.004)K;WQS(0.998)PVT(0.002)K;WQS(0.999)PVT(0.001)K 110.53 0.015375 941772000.0 813370.0 716750.0 853960.0 870200.0 882080.0 613530.0 652700.0 691170.0 572510.0 766200.0 True False 768166.1515780898 771722.4202855055 799017.1433213464 751677.2588212691 771265.2245047473 698038.1884291797 683051.843300514 693181.1902706474 687027.9972659408 744077.8151733218 1.0323734102987026 1.0371528414749798 1.0738354605226703 1.010213237772957 1.036538395282075 0.9381252527554288 0.9179844222897673 0.9315977121414126 0.9233281563513729 1.0 19.505093979767736 -6.761154136449988 6.9729760086925925 0.9361458243282412 1.0386678633936939 0.7731930565883215 0.025846739943430553 0.05805846426862476 14.860154821590344 0.008527469328130128 0.008006670581703864 1.7331887585877961e-07 6.761154136449988 0.10252203906545265 WREEQMER ddPTM_A459_Selumetinib_30min_R1 4 WREEQMER 8 1 P09496-2;F8WF69;P09496-4;P09496-3;P09496 P09496-2 CLTA Clathrin light chain A 0 ;;; 146.79 0.005076300000000001 142116000.0 11036.3 13266.2 14591.2 15162.1 14840.100000000002 12026.599999999999 12449.099999999999 11789.800000000001 7299.0 10130.7 False True 11293.424317098445 11712.987136710946 12609.795183724485 12514.323862866611 13497.815575232451 11905.623323279104 11510.054364172085 11477.09620533239 12385.869902132206 11431.074026374476 0.9879582873001752 1.0246619967367916 1.1031155213088808 1.0947636096129545 1.1808002943633698 1.0415139728611431 1.0069092665846955 1.0040260590432473 1.0835263487538238 1.0 13.480673340383497 -6.985917315944511 24.999983492395575 1.0239881410332037 1.0809377220157943 0.19810439728017815 0.05222841908356705 404.8070903384658 718622.3941747765 0.01978517210763005 0.017441168102879687 1.0329580489017262e-07 6.985917315944511 0.05694958098259062 WREEQMER ddPTM_A459_Selumetinib_30min_R2 5 WREEQMER 8 1 P09496-2;F8WF69;P09496-4;P09496-3;P09496 P09496-2 CLTA Clathrin light chain A 0 ;;;; 129.42 0.011496 155672000.0 185351.0 166039.0 206204.0 217329.0 226630.0 154470.0 165097.0 183545.0 156181.0 183003.0 False True 175049.9334388415 178773.65740046708 192937.05913793956 187728.41528656363 198158.71330209388 175746.84036095263 172774.33763349915 184079.0855624895 187421.56406174894 177719.22789110334 0.9849802720620785 1.0059331200223864 1.0856285019207987 1.05632022777858 1.1150099831826568 0.9889016649827036 0.9721758286017642 1.0357859852693212 1.0545936209929443 1.0 17.43924025305978 -9.280496122430002 13.691868036239352 0.9999999994309429 1.0340512625353178 0.04902595518511377 0.04381903486675883 0.0 0.0 0.045566247958179915 0.0110514384290977 5.242082813470699e-10 9.280496122430002 0.034051263104374896 WRPEDAEEAEHR ddPTM_A459_Selumetinib_30min_R1 2 WRPEDAEEAEHR 12 1 E7EUV9;F8W8D3;Q14493;H0YAE8 E7EUV9 SLBP Histone RNA hairpin-binding protein 0 ; 173.76 0.00013604 6850700.0 3379.3 4188.6 4573.299999999999 3966.0 4137.9 3829.9 3321.3 3348.6000000000004 2401.46 3027.6000000000004 False True 3458.031115026845 3698.196764772691 3952.2709793387216 3273.412551040357 3763.6276756055804 3791.374683270969 3070.7716670060286 3259.784250214255 4075.102224301194 3416.2219513213636 1.0122384213617355 1.0825399571424983 1.1569128223094578 0.9581966856030039 1.1016929605963814 1.109815093192203 0.8988794378006623 0.9542073953811461 1.1928681105526475 1.0 11.738185994300963 WRPEDAEEAEHR ddPTM_A459_Selumetinib_30min_R2 1 WRPEDAEEAEHR 12 1 E7EUV9;F8W8D3;Q14493;H0YAE8 E7EUV9 SLBP Histone RNA hairpin-binding protein 0 77.64399999999998 0.036206 3623700.0 22090.0 25321.0 29405.0 25829.0 31475.0 21750.0 19269.0 23320.0 23508.0 24391.0 False True 20862.326233276366 27263.03928015245 27513.11431374327 22311.04564248975 27520.829109929873 24745.86507315806 20165.046680799143 23387.857339166174 28210.256868400156 23686.768454571276 0.8807586511130933 1.1509817952769743 1.1615393786835262 0.9419201984128811 1.1618650793463836 1.0447125837624502 0.8513211381904449 0.9873806713660251 1.1909711078784113 1.0 14.53179376712829 -7.012521991991411 24.70387400787877 0.9980309436845399 1.0676107196912494 0.03855368412773186 0.11586025879485809 1546.0511952259185 3050110.7043430735 0.04286149326331894 0.034920277649906 9.715787511072784e-08 7.012521991991411 0.0695797760067095 WRPHS(ph)PDGPR ddPTM_A459_Selumetinib_30min_R1 3 WRPHSPDGPR 10 1 Q6Y7W6;I1E4Y6;Q6Y7W6-3;C9IYH5;C9JH78 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 WRPHS(1)PDGPR;WRPHS(1)PDGPR;WRPHS(1)PDGPR 81.97200000000002 0.018744 136943000.0 7992.7 9896.0 9889.699999999999 10516.1 10131.5 8178.800000000001 9126.4 8591.6 5125.24 6824.9 True False 8178.914358913108 8737.371719474417 8546.733060233564 8679.660546645353 9215.107613861606 8096.528697756243 8437.988300293204 8363.722858550078 8697.15794728101 7700.942395155623 1.062066684729152 1.1345847392613628 1.1098295015958044 1.1270906989390552 1.1966207693825224 1.0513685575481604 1.0957085337505224 1.0860648514669302 1.1293628105505722 1.0 12.910819289641706 -11.25983931453872 7.456812819196409 0.9987852136449101 1.1111576204000582 0.41709709287050156 0.03910602115356988 0.0008007211162789895 2.8245387881710896e-05 0.038389134839073996 0.009214059826235974 5.497442371750163e-12 11.25983931453872 0.11237240675514804 WRPHS(ph)PDGPR ddPTM_A459_Selumetinib_30min_R2 3 WRPHSPDGPR 10 1 Q6Y7W6;I1E4Y6;Q6Y7W6-3;C9IYH5;C9JH78 Q6Y7W6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 WRPHS(1)PDGPR;WRPHS(1)PDGPR;WRPHS(1)PDGPR 80.87100000000002 0.024895 338967300.0 216661.7 197052.80000000002 199488.8 220702.69999999998 251305.4 171660.2 175017.6 160612.3 132894.6 198708.30000000002 True False 204620.51007950443 212166.11613538265 186653.90779498254 190642.61152660707 219734.1689532188 195304.834373854 183156.26519079518 161079.6552022022 159477.2333853706 192971.07507283328 1.0603688143535206 1.0994710790480104 0.9672636571285803 0.9879336136498832 1.138689665641777 1.0120938296070532 0.9491384401608703 0.8347347142125096 0.8264307659848967 1.0 17.55802508889223 -7.395044412248985 2.6863449367206025 0.8746912092441026 1.0463632217096042 0.5445581571607652 0.06495144603741977 0.20564580895786547 2.8763780405172574 0.0321719212462963 0.019589351438007545 4.0267585338612085e-08 7.395044412248985 0.17167201246550157 WRS(ph)LQQLAEER ddPTM_A459_Selumetinib_30min_R1 1 WRSLQQLAEER 11 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 WRS(1)LQQLAEER 77.633 0.027007 4104000.0 1154.7 1269.2 1487.9 1686.3 1432.2 1292.2 1388.5 1558.7 707.01 998.75 True False 1181.6022633449224 1120.601473964928 1285.8513524496714 1391.8193607713943 1302.6577628754478 1279.201641223726 1283.764327112237 1517.3582126288486 1199.7443320326738 1126.9492911488342 1.0484963898778215 0.9943672557108268 1.141001962154703 1.2350328197576188 1.1559151535092524 1.135101331773041 1.1391500373575305 1.3464298922288012 1.0645947794240422 1.0 10.138206885306207 -5.3495623996032124 4.971546672723801 1.1680601297062572 1.021999450662791 0.24607692524389657 0.08890254914585295 0.24180740275947843 9.943020681692545 0.022336609498966552 0.048657151222132024 4.471339027969079e-06 5.3495623996032124 -0.1460606790434662 WRS(ph)LQQLAEER ddPTM_A459_Selumetinib_30min_R2 1 WRSLQQLAEER 11 1 A0A0D9SF54;A0A0D9SGF6;Q13813-3;Q13813;Q13813-2 A0A0D9SF54 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 WRS(1)LQQLAEER 65.565 0.044074 3287000.0 8152.3 8739.9 11955.0 8359.0 9138.3 5497.8 5367.0 5456.9 5739.9 8403.9 True False 7699.227802242591 9410.222226792166 11185.828315619821 7220.4897799207065 7990.265056561462 6255.072045940615 5616.576134508744 5472.778675561575 6888.040386205969 8161.257571045532 0.9433874295988246 1.1530358091108048 1.3706010646330837 0.8847275946218782 0.9790482639476156 0.7664348283936445 0.6881998375391563 0.6705803153398652 0.8439925252014253 1.0 12.994575759373731 -6.289428023604473 1.6542649394385227 0.7716236886526499 1.141706930655634 0.4825625260539014 0.14624299404130778 0.2903459032452795 1.5753870635985396 0.05322946343270802 0.06996972217561538 5.135372798958115e-07 6.289428023604473 0.37008324200298415 WS(ph)DQGPAQTSR ddPTM_A459_Selumetinib_30min_R2 3 WSDQGPAQTSR 11 0 Q9C0C2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 WS(1)DQGPAQTSR;WS(1)DQGPAQTSR;WS(1)DQGPAQTSR 153.0 0.00056833 52715000.0 238191.0 204043.0 229296.0 239820.0 236312.0 199492.0 255103.0 206516.0 138531.0 224818.0 True False 224953.2977741208 219692.44199834767 214543.34499860866 207156.1022874247 206624.37390391564 226970.21219192867 266965.7949770047 207116.92736943564 166241.07087954498 218326.9201926856 1.0303507124801057 1.0062544820604666 0.9826701389332213 0.9488344456313402 0.9463989769175427 1.0395887597902032 1.2227800160483764 0.9486550132555504 0.7614318506065493 1.0 17.736130503226377 -8.000648164006853 24.999998955287435 0.8721583960906594 1.0223505124934091 0.2932230516092116 0.09063324550894478 26.388920838601575 1017808.2923686617 0.05173046953727995 0.02438470197323152 9.98508660373811e-09 8.000648164006853 0.15019211640274976 WS(ph)GNEPTDEFSDLPLR ddPTM_A459_Selumetinib_30min_R1 2 WSGNEPTDEFSDLPLR 16 0 Q96II8-3;Q96II8;Q96II8-2;E9PD99;Q96II8-4 Q96II8-3 LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 1 WS(0.995)GNEPT(0.004)DEFS(0.001)DLPLR;WS(0.996)GNEPT(0.004)DEFSDLPLR 202.94 4.1756e-07 25562000.0 760.8299999999999 1239.56 856.3 1048.07 1065.8200000000002 1038.7 1361.43 1128.71 504.03999999999996 811.39 True False 778.5558586825299 1094.43173894419 740.0191633192111 865.0442492105059 969.4167691858044 1028.2516210641413 1258.7362390064184 1098.7729442332115 855.319066374944 915.5398101078883 0.8503790333167314 1.1953950301901355 0.8082872586742091 0.9448461330245902 1.058847205204072 1.123109677713491 1.3748569151330376 1.2001367194548653 0.9342237846262 1.0 9.83847880938174 -6.549843460086949 2.827980983358664 1.154355280464894 0.9587035333155485 0.23338113297602325 0.14647420659236982 0.37471560105514634 6.103192415422721 0.05164896682134578 0.054178187959577774 2.819398990550331e-07 6.549843460086949 -0.19565174714934552 WS(ph)GNEPTDEFSDLPLR ddPTM_A459_Selumetinib_30min_R2 3 WSGNEPTDEFSDLPLR 16 0 Q96II8-3;Q96II8;Q96II8-2;E9PD99;Q96II8-4 Q96II8-3 LRCH3 Leucine-rich repeat and calponin homology domain-containing protein 3 1 WS(0.986)GNEPT(0.014)DEFSDLPLR;WS(0.56)GNEPT(0.42)DEFS(0.02)DLPLR;WS(0.709)GNEPT(0.291)DEFSDLPLR 138.05 0.00053625 2433500.0 11776.2 10164.5 11491.900000000001 14835.599999999999 13485.4 9098.7 8416.4 11708.300000000001 10830.4 9708.1 True False 11121.725947863706 10944.084465981183 10752.523665434672 12814.965687162527 11791.243490994375 10351.963335224975 8807.779276780211 11742.36921458659 12996.782626659904 9427.801928326979 1.1796732719264207 1.160830970907264 1.1405122580192744 1.3592739627524844 1.2506885041322462 1.0980251191023902 0.9342346544549441 1.2455044456656659 1.378559151482541 1.0 13.202705733532076 -6.759742155939699 24.99859303016878 1.134294324291723 1.2185307850499767 0.1035372625117813 0.12774041181250304 128.2016096495322 1888313.632692209 0.0461999206187473 0.043917131767892977 1.7388328811504109e-07 6.759742155939699 0.08423646075825375 WS(ph)IPADGR ddPTM_A459_Selumetinib_30min_R2 1 WSIPADGR 8 0 P55040;E5RJF9 P55040 GEM GTP-binding protein GEM 1 WS(1)IPADGR 81.525 0.043521 2599200.0 20018.0 20762.0 22589.0 24160.0 25295.0 23120.0 19489.0 20464.0 15856.0 22043.0 True False 18905.479698403182 22354.37863964793 21135.6483330436 20869.36632167536 22117.21595983085 26304.57013753629 20395.277116720863 20523.54685200243 19027.643053656313 21406.561315407915 0.8831628499246856 1.0442769537000696 0.9873443950958476 0.9749051243767071 1.0331979823359776 1.2288087633487828 0.9527582135315141 0.9587502892036232 0.888869668196577 1.0 14.385765443762146 -7.482366600031893 24.998443169460703 0.9454364423897329 1.0281824724756317 0.15695623515519053 0.08510361440518219 930.0649325905615 573907.7282856011 0.03676536487988397 0.024783406925365823 3.293315968655751e-08 7.482366600031893 0.08274603008589876 WS(ph)PPQNYK ddPTM_A459_Selumetinib_30min_R1 1 WSPPQNYK 8 0 H3BRF9;Q96K21-3;Q96K21-2;Q96K21;H3BRM1 H3BRF9 ZFYVE19 Abscission/NoCut checkpoint regulator 1 WS(1)PPQNYK 89.67299999999999 0.029338 67142000.0 3233.7 3882.9 3308.7 3764.0 3562.7 3116.8 3619.5 3716.9 1649.1 2774.8 True False 3309.0389183151246 3428.2882628887633 2859.39671338815 3106.6880590307346 3240.454414045773 3085.447821827975 3346.47820092383 3618.315737807253 2798.4022545014673 3130.9726088408374 1.0568725222863613 1.0949595193545942 0.9132614911143437 0.9922437680414287 1.0349673468543912 0.9854598577821104 1.0688302387170285 1.155652313147141 0.8937804970250136 1.0 11.612395171847599 -8.299906075944426 24.99987771830468 0.9468902829784264 1.033215530370889 0.22628612465773057 0.06680104277073533 1035.1140370222122 672721.6828698965 0.06598187549214178 0.017038612611241274 5.012956361747739e-09 8.299906075944426 0.08632524739246261 WS(ph)PPQNYK ddPTM_A459_Selumetinib_30min_R2 1 WSPPQNYK 8 0 H3BRF9;Q96K21-3;Q96K21-2;Q96K21;H3BRM1 H3BRF9 ZFYVE19 Abscission/NoCut checkpoint regulator 1 WS(1)PPQNYK 112.36 0.011207 24521000.0 64940.0 51641.0 63840.0 72777.0 68791.0 45629.0 49377.0 55279.0 49703.0 61232.0 True False 61330.894775417255 55601.69864801366 59732.6039037365 62864.647052672495 60148.85958065713 51913.98057117832 51673.12833866933 55439.8527380689 59644.98881785318 59464.07306015781 1.0313941110857112 0.9350469247500636 1.0045158501555556 1.0571870344144512 1.0115159706568795 0.8730310236007326 0.8689806412418698 0.9323251819965689 1.0030424380367007 1.0 15.85973066523763 -6.736279271108213 24.875451673331636 0.9270902255345121 1.0064294531507205 0.3314977054866173 0.05073033815625466 248.08083073067877 245273.41902221477 0.017551312405886085 0.017544204015113404 1.8353577452780196e-07 6.736279271108213 0.07933922761620837 WS(ph)TTAGFLK ddPTM_A459_Selumetinib_30min_R1 2 WSTTAGFLK 9 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 WS(0.781)T(0.188)T(0.031)AGFLK;WS(0.604)T(0.114)T(0.283)AGFLK 100.88 0.017523 171729000.0 8519.5 10469.7 6698.0 7103.4 6818.1 8212.4 8913.2 8832.8 4459.2 7310.3 True False 8717.987773938741 9243.902656768523 5788.448389480413 5862.924537332337 6201.404058833323 8129.790712262597 8240.870147941509 8598.525451022058 7566.93671291792 8248.648213352017 1.056898966769732 1.1206566721812061 0.7017450908029634 0.7107739820740654 0.7518085264922758 0.9855906691599448 0.999057049687497 1.0424163121787275 0.9173547613134215 1.0 13.009941994846585 -6.893755620071017 11.43800853278134 0.9930969051158985 0.8644263734201606 0.17242580771190352 0.13179940347400587 0.8037234124839908 80.99232274818013 0.05249767473258382 0.046303387108231404 1.2771572701756608e-07 6.893755620071017 -0.12867053169573794 WS(ph)TTAGFLK ddPTM_A459_Selumetinib_30min_R2 2 WSTTAGFLK 9 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5;Q8TEW0-8;Q8TEW0-9;Q5VWU8;Q8TEW0-10 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 WS(0.992)T(0.008)TAGFLK;WS(0.877)T(0.119)T(0.004)AGFLK 92.538 0.02576 73741000.0 51534.0 45819.0 49691.0 53732.0 48518.0 51586.0 54949.0 51663.0 41009.0 46230.0 True False 48669.946586947226 49333.16996869422 46493.93515947008 46413.60890712996 42422.735083576685 58691.50324891639 57504.23737937784 51813.330776729956 49211.94588719677 44895.21978003486 1.0840785906697132 1.0988512855133175 1.0356099243364474 1.033820730459378 0.9449276624867377 1.3072996086549244 1.280854346211493 1.1540946013983346 1.0961511298599675 1.0 15.454274221692437 -6.755110468345696 24.999997145603793 1.1843842509922389 1.0422303757559315 0.32696748005291976 0.09036282622974266 170.8705361287423 674958.9043535761 0.03089936642279891 0.030187075943142353 1.757476520510121e-07 6.755110468345696 -0.1421538752363074 WSAEASGKPSPSDPGSGTATMMNS(ph)SSR ddPTM_A459_Selumetinib_30min_R2 1 WSAEASGKPSPSDPGSGTATMMNSSSR 27 1 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 WSAEASGKPSPSDPGS(0.013)GT(0.013)AT(0.198)MMNS(0.278)S(0.278)S(0.22)R 64.726 0.0025596 5408400.0 24675.0 12486.0 18726.0 23892.0 19193.0 17213.0 25566.0 24937.0 18323.0 12790.0 True False 23303.662281851266 13443.636051182166 17521.189547327223 20637.86838400112 16781.80375240298 19583.934505943438 26754.86965806794 25009.562541457406 21988.11198739561 12420.719467589133 1.87619262657532 1.0823556627506363 1.4106420801989255 1.6615678695468468 1.3511136610237229 1.576714984751579 2.154051520757925 2.0135357381444647 1.7702768382114913 1.0 13.600461123338132 -7.0139772375486755 23.899539962623145 1.8255639408711026 1.4614004525772328 0.08679137348340749 0.34617684133638593 594.5104705909159 1016546.652701104 0.12256905350485114 0.0990790320112693 9.683286074360756e-08 7.0139772375486755 -0.3641634882938698 WSAEASGKPSPSDPGSGTATMMNSS(ph)SR ddPTM_A459_Selumetinib_30min_R1 1 WSAEASGKPSPSDPGSGTATMMNSSSR 27 1 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 WSAEASGKPSPS(0.001)DPGS(0.032)GT(0.027)AT(0.099)MMNS(0.082)S(0.431)S(0.328)R 67.072 0.00058719 17616000.0 1402.0 1839.6 1196.0 1074.4 1601.3 1422.1 1523.4 1257.8 686.99 1219.0 True False 1434.663872182889 1624.2187767931625 1033.589769157744 886.7762089858187 1456.4626977324765 1407.794965163489 1408.4887115036242 1224.439058089796 1165.771854235622 1375.470524065512 1.0430349811804165 1.18084593480958 0.7514445064971202 0.6447075335098803 1.0588832492226543 1.0235006425309898 1.0240050127286766 0.8901965085160032 0.8475440468109207 1.0 10.425709508111082 -5.245961409991383 24.74676349834393 0.9057906179703101 1.1119404702961713 0.29300612758790145 0.12855425100050882 981.4105711352563 1569109.4966099001 0.03559315631787052 0.09341946020175472 5.675950378344819e-06 5.245961409991383 0.20614985232586114 WSAEASGKPSPSDPGSGTATMMNSS(ph)SR ddPTM_A459_Selumetinib_30min_R2 1 WSAEASGKPSPSDPGSGTATMMNSSSR 27 1 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 WSAEASGKPSPSDPGS(0.004)GT(0.004)AT(0.048)MMNS(0.143)S(0.451)S(0.351)R 76.97 0.00024404 6994700.0 38082.0 14159.0 30892.0 32703.0 24970.0 23803.0 36269.0 35374.0 28913.0 19119.0 True False 35965.55489432462 15244.949771639298 28904.44235266646 28248.794984178356 21833.0453653677 27081.647187879596 37955.58036566007 35476.93248351904 34696.407896718294 18566.984792872307 1.9370703049281035 0.8210783787301691 1.5567655532180222 1.5214530145477798 1.1759068911258657 1.4585915532324878 2.0442511688936627 1.9107535703448364 1.8687152644212819 1.0 14.180451925702434 -7.083041628549892 7.5998403763233595 1.7800529596596375 1.3786827957158034 0.11549178328506393 0.3767334936145738 0.4586080442616285 37.32586240509565 0.13571091409217273 0.10521163422494528 8.259587749262447e-08 7.083041628549892 -0.40137016394383407 WSAEASGKPSPSDPGSGTATMMNSSS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 WSAEASGKPSPSDPGSGTATMMNSSSR 27 1 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 WSAEASGKPSPSDPGSGTAT(0.008)MMNS(0.029)S(0.265)S(0.699)R 91.669 1.1423e-05 15782000.0 2162.6 3285.8 2202.1 1966.4 1919.1 2183.6 2648.4 2917.4 1359.5 2029.2 True False 2212.9843723129206 2901.0970084730207 1903.0669152694559 1623.005153899586 1745.5177438446228 2161.6349665501693 2448.629055760928 2840.0210749492544 2306.9722060486006 2289.6675860818164 0.9665090189357489 1.2670385107899047 0.8311542369021657 0.7088387693328648 0.7623454838838123 0.9440824422244006 1.0694255666828625 1.240363925406844 1.0075576996730764 1.0 11.160922447734645 -7.25622950216688 4.059473608001252 1.1024012962494962 0.9076547333999988 0.2151923970002293 0.15442658022101452 0.3502414398280968 13.87282554219927 0.07203426534304236 0.05096396232022566 5.543326993884371e-08 7.25622950216688 -0.19474656284949743 WSAEASGKPSPSDPGSGTATMMNSSS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 WSAEASGKPSPSDPGSGTATMMNSSSR 27 1 Q5JRA6-4;Q5JRA6-2;Q5JRA6 Q5JRA6-4 MIA3 Melanoma inhibitory activity protein 3 1 WSAEASGKPSPSDPGS(0.02)GT(0.02)AT(0.02)MMNS(0.044)S(0.269)S(0.627)R;WSAEASGKPSPSDPGS(0.024)GT(0.024)AT(0.024)MMNS(0.243)S(0.213)S(0.474)R 57.95 0.0039149 38807000.0 121423.0 40768.0 86399.0 99552.0 77148.0 72095.0 110690.0 109833.0 103135.0 62984.0 True False 114674.79575478114 43894.774510219 80840.18240411836 85992.8458632213 67455.9785281292 82025.4318367507 115837.30432807385 110152.59584616798 123764.8818326721 61165.48826791511 1.8748284204400736 0.7176395669066274 1.3216633218069769 1.405904674324812 1.1028437839433356 1.3410410700469768 1.8938343763510397 1.800894572502734 2.0234430450479053 1.0 15.90043024245589 -7.158199822896589 5.4165319469522135 1.7444190714906438 1.2592343303618634 0.19619366753534384 0.3717241036474435 0.2954680221422373 12.68260258353397 0.13577749122707372 0.10447018208136852 6.947046040473323e-08 7.158199822896589 -0.4851847411287804 WSEPWVPVEALPPS(ph)PLELSR ddPTM_A459_Selumetinib_30min_R2 2 WSEPWVPVEALPPSPLELSR 20 0 O43379;O43379-4 O43379 WDR62 WD repeat-containing protein 62 1 WSEPWVPVEALPPS(1)PLELSR;WSEPWVPVEALPPS(1)PLELSR 256.4 1.6729999999999994e-96 0.0 22427.8 22911.7 24108.1 26065.2 26468.7 19342.7 19013.6 20660.8 19806.0 24911.5 True False 21181.35266159691 24668.953717272983 22557.01109291461 22515.074795022036 23143.465272819718 22006.981349451686 19897.770074733646 20720.919507420444 23767.75342587771 24192.240267149864 0.8755432497236986 1.0197052213792055 0.932406872774999 0.9306734120690254 0.9566482895858861 0.9096710807446181 0.8224856340300328 0.8565109836296123 0.9824535951782623 1.0 14.562256752532262 -6.863786374083728 5.7016921011243475 0.8985294600292654 0.9458259240872208 0.024222452470974765 0.05987022830806629 0.46475832082737667 22.057525259444105 0.020933950375380365 0.018493810208199984 1.3684017657518813e-07 6.863786374083728 0.0472964640579554 WSLQSEAHR ddPTM_A459_Selumetinib_30min_R1 1 WSLQSEAHR 9 0 Q16658 Q16658 FSCN1 Fascin 0 172.88 2.8363e-09 0.0 2993.3 3305.1 3339.5 3417.4 4567.2 3626.3 3796.4 3139.8 1342.2 2086.5 False True 3063.0380660520973 2918.1373555006944 2886.014242560441 2820.615242542942 4154.097566404653 3589.822714416963 3510.034491500825 3056.5223044922404 2277.6153695906078 2354.322599231082 1.3010273388415337 1.2394806711933841 1.2258363588333256 1.198058092575822 1.7644555456254696 1.524779448487388 1.4908893507827672 1.2982597650341101 0.9674185561207598 1.0 11.201096302754264 -8.180093866743837 3.77807974052297 0.9788613077916851 1.3917818092624032 0.4929766973245747 0.16281688107369824 0.21804287031955233 5.631301385100926 0.14556249987505254 0.047557094530696856 6.605506636904288e-09 8.180093866743837 0.4129205014707181 WSLQSEAHR ddPTM_A459_Selumetinib_30min_R2 2 WSLQSEAHR 9 0 Q16658 Q16658 FSCN1 Fascin 0 ; 176.33 0.00064315 7474600.0 76188.0 47049.0 77823.0 104750.0 119802.0 87116.0 69693.0 79411.0 86509.0 95310.0 False True 71953.77596472882 50657.50701362085 72815.95290727568 90482.86929617095 104751.4017165311 99115.43823968912 72933.86259405955 79642.07286280116 103813.21726341765 92558.15265488061 0.7773899316359646 0.547304646436779 0.786704907333045 0.9775786000564669 1.1317360892790844 1.070845035220814 0.7879788057785284 0.8604544340870832 1.1215999270264558 1.0 16.498072449891147 -5.623727910602153 3.4697983864133572 0.9879548803451986 0.6617902731064632 0.5877495981605991 0.1137765815951189 0.1686467126986406 3.946104873483938 0.03375978614410788 0.06342556928349109 2.3783298650040725e-06 5.623727910602153 -0.3261646072387354 WSNS(ph)QPADLAHMGR ddPTM_A459_Selumetinib_30min_R2 2 WSNSQPADLAHMGR 14 0 Q9BRG2;Q9BRG2-2;M0QZQ6 Q9BRG2 SH2D3A SH2 domain-containing protein 3A 1 WS(0.003)NS(0.997)QPADLAHMGR;WS(0.04)NS(0.96)QPADLAHMGR 156.11 0.00021384 13478900.0 48252.0 36023.0 57338.0 57207.0 60216.0 40597.0 50386.0 43094.0 43117.0 45597.0 True False 45570.347008060264 38785.84826779874 53648.93550489417 49415.3079124206 52651.12774212982 46188.868247126324 52729.04883796488 43219.396405404244 51741.604789637946 44280.49613476637 1.029129097139478 0.8759126851188651 1.2115703342983157 1.1159610263179207 1.1890365361284048 1.0430973516320114 1.1907962520899855 0.9760368599725554 1.1684965008559054 1.0 15.43438376623886 -5.256972786807581 24.99669295884395 1.1142825933000857 0.9525208928957314 0.3578453332265069 0.08533858731970402 368.57691079762117 2062673.0306342044 0.020387089111089055 0.05028399091890505 5.53384783602403e-06 5.256972786807581 -0.16176170040435434 WSTELVPEGLQS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 WSTELVPEGLQSPR 14 0 H3BRD5;B2RTY4-5;B2RTY4-2;B2RTY4;B2RTY4-4;H3BMM1;H3BV44 H3BRD5 MYO9A Unconventional myosin-IXa 1 WSTELVPEGLQS(1)PR 73.80199999999998 0.047926 1910900.0 7747.3 7201.2 9800.3 10806.0 11140.0 10413.0 10299.0 10412.0 9999.9 12775.0 True False 7316.73608089914 7753.508884492476 9169.75936775985 9334.20415861026 9740.49360713641 11847.296230197455 10777.923907081335 10442.29719620061 12000.15942055107 12406.152556563822 0.5897667344923964 0.6249728793146482 0.7391299861864372 0.7523850860331182 0.7851341149261404 0.954953292423388 0.8687563576170093 0.8417031105002671 0.9672748554266367 1.0 13.59876815028148 -3.961056793180885 0.26087406510310385 0.99365005500737 8.799547356339108e-21 0.8915643966644565 0.04392664573631808 4.598746036624817 0.18726176990253834 0.05998462541795584 1.5754177368856743 0.0001093813317713572 3.961056793180885 -0.99365005500737 WTDGS(ph)LSPPAKEPLASDSR ddPTM_A459_Selumetinib_30min_R2 1 WTDGSLSPPAKEPLASDSR 19 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 WT(0.015)DGS(0.492)LS(0.492)PPAKEPLAS(0.001)DSR 65.28699999999999 0.013326 38943000.0 76521.0 84355.0 84114.0 81135.0 90292.0 60155.0 77890.0 75387.0 65614.0 73460.0 True False 72268.26915783346 90824.75725592418 78702.19681639853 70084.27303431834 78948.71173927831 68440.8052172792 81512.03933610703 75606.3636890103 78738.633408338 71339.01892799826 1.0130258341619904 1.2731427852630364 1.1032138933089597 0.9824115061780381 1.1066694345623176 0.9593740739041533 1.1426010696667457 1.0598178223521553 1.1037246459445722 1.0 16.122403755188152 -5.522020959337675 24.999553857832115 1.0545339733025123 1.1543578198837492 0.1773873408946981 0.08014809434326901 42.65122319907412 1243036.8843838659 0.020223791131310617 0.03560691115070969 3.005931230907056e-06 5.522020959337675 0.09982384658123689 WTDGSLS(ph)PPAK ddPTM_A459_Selumetinib_30min_R2 1 WTDGSLSPPAK 11 0 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 WTDGS(0.407)LS(0.593)PPAK 108.72 0.0098109 2009100.0 38397.0 25822.0 27857.0 29377.0 28393.0 23966.0 35305.0 35380.0 33872.0 23033.0 True False 36263.04845536953 27802.464369183563 26064.71094840833 25375.801921848368 24826.01750335945 27267.09895831292 36946.75245553031 35482.94994252571 40647.346462755195 22367.977443079024 1.621203729646546 1.2429583515064768 1.1652690107872552 1.1344701140916078 1.1098910291078186 1.2190238937651359 1.6517699264294532 1.5863280456545994 1.817211527783084 1.0 14.449147190494605 -7.253020187586727 23.863575521389738 1.562688048256056 1.2332289235797764 0.21647752147428156 0.23880943969381985 412.06952920433497 1167983.0979404498 0.08955679969446854 0.06812393377751072 5.5844423561477805e-08 7.253020187586727 -0.32945912467627947 WTDGSLS(ph)PPAKEPLASDSR ddPTM_A459_Selumetinib_30min_R1 3 WTDGSLSPPAKEPLASDSR 19 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 WTDGS(0.26)LS(0.739)PPAKEPLAS(0.001)DSR;WT(0.001)DGS(0.086)LS(0.912)PPAKEPLAS(0.001)DSR;WT(0.041)DGS(0.423)LS(0.536)PPAKEPLASDSR 148.52 0.00022679 73842000.0 6524.7 6700.200000000001 7744.2 8314.0 7551.8 6350.9 6915.0 6542.59 3954.9400000000005 5591.8099999999995 True False 6676.712815143861 5915.737469161528 6692.580175845657 6862.115973108801 6868.74102337858 6287.015712155825 6393.395982701561 6369.059259872571 6711.24432261115 6309.573282341891 1.058187696120347 0.9375812284671357 1.0607025033809587 1.0875721171688848 1.0886221169031491 0.9964248659653108 1.0132850030594394 1.009427892326278 1.0636605713722962 1.0 12.623326723425203 WTDGSLS(ph)PPAKEPLASDSR ddPTM_A459_Selumetinib_30min_R2 1 WTDGSLSPPAKEPLASDSR 19 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 1 WT(0.001)DGS(0.218)LS(0.781)PPAKEPLASDSR 59.606 0.023213 7718000.0 26786.0 25171.0 30180.0 33003.0 30913.0 23701.0 23349.0 26510.0 20279.0 26479.0 True False 25297.341352853822 27101.53476247849 28238.25165749949 28507.93446664949 27029.432574273596 26965.597613743394 24434.774765165774 26587.13971103324 24335.36664260194 25714.482469295748 0.9837779695959267 1.0539405097823356 1.0981458285702324 1.1086334131238786 1.0511365572512672 1.0486541055586684 0.9502339700727789 1.0339364108447247 0.9463681282195535 1.0 14.650293497793818 -7.119007006342625 5.419675326742755 0.9857676532151912 1.0625165392560798 0.46843666612019796 0.038950045973435675 0.2155517702318341 8.718761026657283 0.015454940439154229 0.011939562949246736 7.603140109233317e-08 7.119007006342625 0.07674888604088859 WTKPSSFSDS(ph)ER ddPTM_A459_Selumetinib_30min_R2 1 WTKPSSFSDSER 12 1 Q8NC56;H0Y9B7;Q8NC56-2 Q8NC56 LEMD2 LEM domain-containing protein 2 1 WTKPSSFS(0.065)DS(0.935)ER 116.79 0.023385 13316000.0 24617.0 9384.1 20263.0 20188.0 14252.0 15366.0 28318.0 22383.0 23935.0 14819.0 True False 23248.885689658855 10103.830295362695 18959.300640686284 17438.35957375752 12461.536345503426 17482.52702134007 29634.843111052476 22448.13082429487 28722.668799776984 14391.136965614034 1.6155002725086554 0.7020870081012108 1.3174289624223126 1.211743006506329 0.8659174306574132 1.2148120793452635 2.059242656216915 1.5598580485983904 1.995858205533482 1.0 13.812892955634327 -7.1091838073422435 7.0588080429492095 1.6980723342246213 1.1229678425293836 0.3200533153940843 0.3546295000222521 0.2643513146949856 15.096739307718414 0.12625369988620072 0.09776627029004979 7.777073307114745e-08 7.1091838073422435 -0.5751044916952377 WVSELS(ph)YVEEK ddPTM_A459_Selumetinib_30min_R1 2 WVSELSYVEEK 11 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 WVSELS(1)YVEEK;WVSELS(1)YVEEK 150.14 0.00061878 5135200.0 2607.1 3670.7000000000003 2178.32 2064.9 2498.4 2630.5 2921.5 2849.9 2102.14 2918.4 True False 2667.8403574664826 3240.9327375378653 1882.5161086552664 1704.3039779735839 2272.420161128346 2604.039558302904 2701.1289028868555 2774.3113942201544 3567.178045769037 3293.005067623289 0.8101537357766606 0.984186987564217 0.5716711848287448 0.517552795387484 0.6900749055841735 0.7907790922964953 0.8202626013073168 0.8424862207158705 1.083259203224862 1.0 11.685189016768248 -7.898669725621427 1.3667735077699183 1.0409663674644893 0.7206214309413743 0.47147337151791613 0.125781010820181 0.4341155285882328 1.4640548836878555 0.12160028976156033 0.043281249714278346 1.262787500300971e-08 7.898669725621427 -0.320344936523115 WYNHIK ddPTM_A459_Selumetinib_30min_R1 2 WYNHIK 6 0 P24534;C9JZW3;F2Z2G2 P24534 EEF1B2 Elongation factor 1-beta 0 ; 128.0 0.018844 13284100.0 13143.7 15292.099999999999 16799.2 17507.5 15024.2 13730.5 15299.1 12901.5 7778.0 11637.900000000001 False True 13449.922636811862 13501.693822895584 14517.96091140031 14450.143781477314 13665.263762737943 13592.383636296528 14145.076569623929 12559.310310021869 13198.69791735639 13131.7378277457 1.0242302133380914 1.0281726607706265 1.1055628053071314 1.1003984370557558 1.0406287379470043 1.0350788155073842 1.0771671468902748 0.9564088527175464 1.0050991034460963 1.0 13.680770231771671 -7.75604984745169 24.99910783708986 0.9855654795871015 1.059367615922192 0.5520185703166753 0.02953512286070476 99.79092206751447 462882.96034786926 0.015337187561412155 0.008530243291384354 1.7536792064993086e-08 7.75604984745169 0.07380213633509058 WYNHIK ddPTM_A459_Selumetinib_30min_R2 1 WYNHIK 6 0 P24534;C9JZW3;F2Z2G2 P24534 EEF1B2 Elongation factor 1-beta 0 128.0 0.018844 2259300.0 44327.0 47475.0 45851.0 53027.0 52445.0 41689.0 41225.0 41769.0 38949.0 49047.0 False True 41863.48279504038 51116.17984381497 42900.99657879422 45804.63112332276 45856.3902357513 47431.28133493729 43142.04418578777 41890.540874769795 46739.88832598765 47630.88567058989 0.8789146413225181 1.0731729869003277 0.9006970157030656 0.9616581862471064 0.9627448574626387 0.9958093507428554 0.9057577573541994 0.8794827197730544 0.9812937061308439 1.0 15.53960975463577 -7.2673846743083965 24.961601354215304 0.9315904412619047 0.9644210981462261 0.0163671163218998 0.058930109133425536 1468.2025632079958 6164299.911988112 0.022952186311139794 0.015919228011697727 5.4027556439072045e-08 7.2673846743083965 0.03283065688432141 Y(ph)DS(ph)VS(ph)VFNGAVSDDSRR ddPTM_A459_Selumetinib_30min_R1 1 YDSVSVFNGAVSDDSRR 17 1 Q15113 Q15113 PCOLCE Procollagen C-endopeptidase enhancer 1 3 Y(1)DS(1)VS(1)VFNGAVSDDSRR 62.055 0.034312 2866700.0 2483.5 2534.8 2960.9 2753.0 2485.1 2529.0 2434.9 2024.2 1203.5 1958.7 True False 2541.3607179502155 2238.024437603451 2558.8260430595014 2272.240230210311 2260.323143780039 2503.560556148277 2251.233532650764 1970.5116404717485 2042.2515998378005 2210.1182243536637 1.149875463650105 1.012626570353696 1.1577779029480721 1.0281080012698482 1.0227159429179666 1.1327722329788168 1.0186032167166643 0.8915865308734845 0.9240463145065668 1.0 11.109907829449288 -7.560206661499037 5.0140954108430105 0.9326136900992812 1.0788099432390093 0.5788050918129927 0.05540726078801621 0.12997267388312153 7.935432436394084 0.025448032466589807 0.014635801675990493 2.752918399728882e-08 7.560206661499037 0.14619625313972806 Y(ph)DSQVAEENRFHPSMLSNY(ph)LKSLK ddPTM_A459_Selumetinib_30min_R2 1 YDSQVAEENRFHPSMLSNYLKSLK 24 2 O60942-3;O60942-4;O60942-2;O60942 O60942-3 RNGTT mRNA-capping enzyme;Polynucleotide 5-triphosphatase;mRNA guanylyltransferase 2 Y(0.761)DS(0.234)QVAEENRFHPS(0.007)MLS(0.047)NY(0.504)LKS(0.447)LK 42.348 0.027835 6183600.0 4214.5 4431.4 8547.9 17882.0 13800.0 13345.0 7363.4 13422.0 14501.0 10185.0 True False 3980.2749619802285 4771.27413080319 7997.937420249825 15446.440751829401 12066.320626434695 15183.152616151458 7705.8126903003 13461.055797868277 17401.60519179303 9890.932586191975 0.4024165494300109 0.48238870189692984 0.8086130757189847 1.561676881044875 1.2199376066195846 1.5350577393831977 0.7790784764884391 1.360949099649137 1.7593492868494696 1.0 13.271890839422383 -5.539539441767054 3.649693506142567 1.3132867178693706 0.4637022080242984 0.6374202712043939 0.2682616210228469 0.13946354829870722 3.999108551258329 0.07413154822366577 0.14817579402737563 2.887091567328553e-06 5.539539441767054 -0.8495845098450722 Y(ph)EILKALDYCHSMGIMHRDVK ddPTM_A459_Selumetinib_30min_R1 1 YEILKALDYCHSMGIMHRDVK 21 2 P68400-2;V9GYW6 P68400-2 CSNK2A1 Casein kinase II subunit alpha 1 Y(0.952)EILKALDY(0.047)CHS(0.001)MGIMHRDVK 45.608 0.033295 22218000.0 2185.7 1693.9 1802.8 1849.6 1367.5 1878.4 1392.1 1337.1 1097.9 1248.5 True False 2236.6225573681445 1495.5774005272535 1557.9896620715558 1526.6020812920426 1243.8098664517345 1859.505001450741 1287.09277621386 1301.6357644870936 1863.0561125566458 1408.757136419845 1.5876565942744405 1.0616289790929114 1.105932045910315 1.08365171101932 0.8829129125923717 1.319961371181698 0.9136370939598732 0.9239603696312162 1.3224821116373093 1.0 10.460207203419081 -4.761230576914321 24.970627858342695 1.0647673183023314 1.587657175770704 0.5319681422991062 0.14612826525682387 3.6901201055224364 440259.772759638 0.034517984735754605 0.19445285713548005 1.7328837257120985e-05 4.761230576914321 0.5228898574683727 Y(ph)FDSGDYNMAK ddPTM_A459_Selumetinib_30min_R2 1 YFDSGDYNMAK 11 0 A6NMQ3;Q5T5H1;O43768-2;O43768;O43768-9;O43768-3;O43768-4;O43768-6;O43768-5;O43768-7;H3BQ52;H3BTD3;P56211-2;H3BMD8;P56211 A6NMQ3;H3BTD3;P56211 ENSA;ARPP19 Alpha-endosulfine;cAMP-regulated phosphoprotein 19 1 Y(0.923)FDS(0.077)GDYNMAK 150.27 0.0086211 308140000.0 126050.0 98589.0 145940.0 151290.0 149800.0 125990.0 96384.0 123050.0 89631.0 115110.0 True False 119044.64561812977 106150.4592864006 136550.37928745788 130684.04101019278 130980.78477100849 143343.97887665225 100866.04698127274 123408.055127976 107559.70449938647 111786.47520830219 1.064928877990855 0.9495823093858226 1.2215286243976367 1.1690505561310256 1.1717051148355806 1.282301625572736 0.90230993323047 1.1039623075870155 0.9621888900151867 1.0 16.770386124780444 -7.272617402543784 24.987154645952867 1.000778816985033 1.140416273395282 0.3705331785839092 0.09615523561161984 956.4555051540216 2138035.6181960655 0.04210927342288254 0.028668868254215777 5.3380495092381755e-08 7.272617402543784 0.13963745641024916 Y(ph)FT(ph)TTRST(ph)LVNKEPDS(ph)MLAHMFK ddPTM_A459_Selumetinib_30min_R2 2 YFTTTRSTLVNKEPDSMLAHMFK 23 2 Q7L273 Q7L273 KCTD9 BTB/POZ domain-containing protein KCTD9 4 Y(0.973)FT(0.671)T(0.204)T(0.204)RS(0.211)T(0.737)LVNKEPDS(1)MLAHMFK;Y(0.756)FT(0.41)T(0.41)T(0.41)RS(0.238)T(0.777)LVNKEPDS(0.999)MLAHMFK 55.76300000000001 0.007559399999999998 11649000.0 17193.199999999997 21706.0 52783.0 73205.0 87262.0 52639.0 27226.0 61815.0 75776.0 102967.0 True False 16237.670773832835 23370.780404209516 49386.999245785155 63234.35271433126 76299.36742782216 59889.54444073408 28492.062947295515 61994.87141597586 90933.31735834124 99994.07516960514 0.1623863288528973 0.2337216516535517 0.4938992551510407 0.6323809946446945 0.7630388830378884 0.5989309300491285 0.28493751153724506 0.6199854472459807 0.9093870532239487 1.0 16.609554994670233 -6.738944137834859 0.18057895330938611 1.0986711444308712 8.284102141988624e-16 0.5950680309484677 0.16966120865309142 6.173579753545571 0.519695565258829 0.8522065952913895 1.9845494372281383 1.824130320349946e-07 6.738944137834859 -1.0986711444308703 Y(ph)IEPLRRMINKIDK ddPTM_A459_Selumetinib_30min_R2 1 YIEPLRRMINKIDK 14 3 G3V1P5;Q96RN5-3;Q96RN5-2;Q96RN5 G3V1P5 MED15 Mediator of RNA polymerase II transcription subunit 15 1 Y(1)IEPLRRMINKIDK 60.518 0.042274 0.0 5361.6 3661.5 3327.8 3807.5 3107.2 3859.1 1581.1 1899.6 1546.0 4543.0 True False 5063.623736185359 3942.3252764218705 3113.692971034686 3288.911931696144 2716.845757279557 4390.655995578126 1654.624282890213 1905.1275215042906 1855.2431988491853 4411.831785868448 1.1477372624234379 0.8935801426177546 0.7057596758353675 0.7454753697162408 0.615809008399163 0.995200227180431 0.3750424683439077 0.4318223391033653 0.4205153978879523 1.0 12.107162069625875 -1.5228787453011532 0.4857685551030649 0.5892616693434312 16.74949566681987 0.3597871832195173 0.2069470109637288 106.65235203247728 1.177519952394106 0.11887185454410686 1745.7976058065708 0.029999999998562107 1.5228787453011532 16.160233997476436 Y(ph)LKY(ph)ENTQ ddPTM_A459_Selumetinib_30min_R1 1 YLKYENTQ 8 1 Q96Q27;Q96Q27-2 Q96Q27 ASB2 Ankyrin repeat and SOCS box protein 2 2 Y(1)LKY(1)ENTQ 66.07300000000001 0.047028 0.0 1319.0 1833.8 2021.3 2333.5 1901.4 1705.5 1560.7 1373.8 938.44 1089.4 True False 1349.730133672774 1619.097843489508 1746.818562206143 1925.9980302200381 1729.4187057194351 1688.3442184701016 1442.9751424732208 1337.3623612686922 1592.4641390542467 1229.2351016546083 1.0980243989583227 1.3171588098241955 1.4210614062800866 1.5668264171984303 1.4069063789274778 1.3734917073206832 1.1738805217414539 1.0879630426014841 1.2954919176248019 1.0 10.26354515444395 -7.293657730402314 4.424939296105582 1.1424732339470067 1.3764560388560874 0.419700242717133 0.12926358251338288 0.22429542598153066 10.598943707079775 0.05795914179907703 0.039568257577626845 5.0856008334645616e-08 7.293657730402314 0.23398280490908063 Y(ph)LLGDAPVSPSSQK ddPTM_A459_Selumetinib_30min_R2 3 YLLGDAPVSPSSQK 14 0 Q9NYB0;A0A590UJT3;H3BMI8 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 Y(1)LLGDAPVSPSSQK;Y(0.702)LLGDAPVS(0.295)PS(0.002)S(0.001)QK;Y(0.995)LLGDAPVS(0.005)PSSQK 155.0 0.0046608000000000005 267581000.0 382714.0 345324.0 418356.0 419597.0 437635.0 276061.0 328017.0 338829.0 281089.0 381141.0 True False 361444.28800552874 371809.2404083318 391439.430431572 362447.16475480096 382655.3787934599 314085.8969177512 343270.44045335497 339814.9362938397 337314.6542828709 370136.4690067543 0.976516280536877 1.0045193368977294 1.0575543433533674 0.9792257588867499 1.0338224164192726 0.848567820838048 0.9274158835915489 0.9180801265158196 0.9113250990588434 1.0 18.49769776371756 -6.743515571743181 24.99970918897443 0.9163539116272238 1.0109007839063997 0.542911215029892 0.04082959266809954 172.59535548493818 240731.59113785822 0.01283700218571064 0.012811272652573142 1.8050300161440288e-07 6.743515571743181 0.09454687227917591 Y(ph)LTMLQT(ph)QQK ddPTM_A459_Selumetinib_30min_R2 1 YLTMLQTQQK 10 0 F8W9J4;Q03001;E9PHM6;F6QMI7;Q03001-8;Q03001-14 F8W9J4 DST Dystonin 2 Y(0.997)LT(0.004)MLQT(1)QQK 94.309 0.028975 0.0 50668.0 42655.0 59888.0 71813.0 76590.0 55919.0 55090.0 66549.0 44336.0 68283.0 True False 47852.07540007458 45926.50134255769 56034.87128112425 62031.94551566519 66968.07947671264 63621.3346678586 57651.794158764045 66742.64657221992 53204.43885134372 66311.49236945974 0.72162567437727 0.6925873585633474 0.8450250368204884 0.9354629687724306 1.009901558293918 0.9594315011549928 0.869408787206183 1.0065019529398913 0.8023411470655942 1.0 16.01697130339584 -5.470203507949442 2.633912475071075 0.9414306046187735 0.7048474800345929 0.6922678022225801 0.061786774782751595 0.1482898716243048 2.0092874044152804 0.016732691431582323 0.04006815342935511 3.3868541287109967e-06 5.470203507949442 -0.23658312458418063 Y(ph)MEDSTYYK ddPTM_A459_Selumetinib_30min_R1 1 YMEDSTYYK 9 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-4;Q05397-3;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 Y(1)MEDSTYYK 145.16 0.026310000000000004 12377000.0 2356.0 2706.6 3317.2 3788.8 2976.6 2653.8 2772.0 2965.4 1756.6 2509.3 True False 2410.890216022029 2389.7100137357984 2866.7424600753097 3127.1572045843923 2707.3670555614144 2627.1051814576094 2562.9058082499973 2886.747959023279 2980.821903012115 2831.3930976518345 0.8514855171545972 0.8440050290853862 1.012484795012318 1.104458864146361 0.9561961063642915 0.927848974286316 0.9051748449819623 1.0195503977944114 1.0527757185973952 1.0 11.467296344984126 -5.258047531424022 24.745657339582188 0.9945963692310698 0.8477452533459908 0.5404796424956306 0.05511849754570435 208.83475556098244 1523560.5203886416 0.015781129968347987 0.03830953831852598 5.52017020389824e-06 5.258047531424022 -0.14685111588507893 Y(ph)MEDSTYYK ddPTM_A459_Selumetinib_30min_R2 3 YMEDSTYYK 9 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-4;Q05397-3;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 Y(1)MEDSTYYK;Y(0.998)MEDS(0.002)TYYK;Y(1)MEDSTYYK 171.53 0.0077916 24633000.0 120756.0 111600.0 124876.0 140664.0 134417.0 90553.0 101608.0 108538.0 78198.0 115453.0 True False 114044.86494456865 120159.36114944161 116841.61411470837 121505.32054106562 117530.33475677326 103025.85379170935 106332.97333243249 108853.82761056676 93839.78503467573 112119.5719070814 1.0171717837014471 1.0717072773790393 1.04211612769571 1.0837119556767718 1.0482588611217318 0.9188926789436155 0.9483890414829221 0.9708726653075245 0.8369616779525795 1.0 16.7746786154583 -6.754594760932948 23.03895957741299 0.934038107988052 1.0548019284898356 0.6534872409065342 0.042788167549846094 35.42655547557718 119245.04765601503 0.013599644418528864 0.013280166001236682 1.7595646934981002e-07 6.754594760932948 0.12076382050178358 Y(ph)MLVRY(ph)EDLARNPMKK ddPTM_A459_Selumetinib_30min_R2 1 YMLVRYEDLARNPMKK 16 3 O43916 O43916 CHST1 Carbohydrate sulfotransferase 1 2 Y(1)MLVRY(1)EDLARNPMKK 53.94600000000001 0.044566 0.0 50983.0 55558.0 67880.0 64905.0 69079.0 51152.0 50414.0 54191.0 47489.0 63574.0 True False 48149.568961119454 59819.1199528735 63512.67470215584 56064.827032629866 60400.67844590451 58197.723688376136 52758.35089344587 54348.68683819699 56988.12695352451 61738.453434911025 0.7798959365232898 0.9689118632675012 1.028737701845987 0.9081022266250532 0.9783315759534389 0.9426495231166137 0.8545460399176892 0.8803052848658601 0.9230572484878546 1.0 15.913881723051071 -9.494358720273492 15.867343038345732 0.999992332792531 0.9222116593368093 0.11799903069824769 0.06624514661515044 0.0 0.0 0.0654989998770774 0.015885840874441667 3.203622090927e-10 9.494358720273492 -0.0777806734557217 Y(ph)MMTRDY(ph)LS(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 YMMTRDYLSVK 11 1 E5RFR9;A0A590UJJ1;A0A590UJY3;P63151;Q66LE6;P63151-2 E5RFR9 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 3 Y(0.556)MMT(0.444)RDY(1)LS(1)VK 62.408 0.042164 0.0 1099.8 1240.2 1241.2 1321.9 1392.4 1116.4 1457.0 1199.5 709.71 1132.4 True False 1125.4232001617263 1094.9968074466624 1072.6518574235724 1091.0549801362192 1266.457665848186 1105.1700296100976 1347.0973169625702 1167.685363474885 1204.3260348324775 1277.7545705100788 0.880781979682106 0.8569695876803167 0.8394819178736105 0.8538846233206356 0.9911587836016247 0.8649313844120428 1.0542692220031034 0.9138573169092604 0.9425331457446569 1.0 10.319395036509254 -6.249694487933711 24.429303133384185 0.9566653733701029 0.8564146911414122 0.5159516552148835 0.04891703726939257 455.9477927075004 948367.7829713032 0.013846736149560137 0.017717229275123907 5.62737053227747e-07 6.249694487933711 -0.10025068222869071 Y(ph)MT(ph)LNVQSKK ddPTM_A459_Selumetinib_30min_R1 1 YMTLNVQSKK 10 1 Q4KN30;Q4KN05;Q4KMZ4;Q9NZS2-3;Q9NZS2-4;Q9NZS2-2;Q9NZS2 Q4KN30 KLRF1 Killer cell lectin-like receptor subfamily F member 1 2 Y(1)MT(0.984)LNVQS(0.016)KK 68.786 0.02653 11071000.0 2350.7 3522.7 3255.8 3685.4 2914.5 3095.6 2788.0 2882.0 1266.7 2061.0 True False 2405.4667363340345 3110.2606463412008 2813.680242829252 3041.8140735260044 2650.883989596768 3064.461074579916 2577.698915368322 2805.55999794466 2149.497383892432 2325.5494258400477 1.0343649159230914 1.3374304634345475 1.209899136765446 1.3079980325196587 1.1398957855471945 1.317736376844777 1.108425771014173 1.2064073834643272 0.9242965812760479 1.0 11.183355887030125 -8.25493219028845 24.170117434823116 0.9621482749838619 1.213595318488414 0.5262918739011124 0.09308007493022387 209.10372021296766 776700.1075419347 0.06191823428912141 0.022113782340747457 5.559910616207192e-09 8.25493219028845 0.25144704350455216 Y(ph)NLDASEEEDSNK ddPTM_A459_Selumetinib_30min_R2 1 YNLDASEEEDSNK 13 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 Y(0.705)NLDAS(0.293)EEEDS(0.002)NK 141.08 0.011848 71696000.0 47047.0 33586.0 48044.0 40395.0 47444.0 39745.0 56645.0 60020.0 46231.0 31599.0 True False 44432.31608406305 36161.9382039888 44952.90134635206 34893.13131473823 41483.66056525851 45219.51298081227 59279.10473993813 60194.64826315409 55478.4918020677 30686.65476593816 1.4479361280325158 1.1784255559888575 1.4649006771585045 1.1370783678079246 1.3518469472047148 1.473588871961548 1.9317551943047655 1.9615904282264573 1.8079028889016666 1.0 14.9053237618922 -7.029399832698903 3.896270300212392 1.7544084583814181 1.3110788250381746 0.2592223664597242 0.27217133915843494 0.23925194356176174 7.890711319253631 0.10013469807971037 0.08026289977216988 9.345448903253369e-08 7.029399832698903 -0.4433296333432435 Y(ph)NTEGRVSPSPSQESLSSSK ddPTM_A459_Selumetinib_30min_R2 1 YNTEGRVSPSPSQESLSSSK 20 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83;Q5JSH3-3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 Y(0.46)NT(0.46)EGRVS(0.074)PS(0.005)PS(0.001)QESLSSSK 89.507 0.016605 27730000.0 28702.0 20385.0 26612.0 24109.0 27005.0 14779.0 19222.0 21199.0 16085.0 26110.0 True False 27106.857743209515 21948.463951894006 24899.8128929548 20825.31260965526 23612.39047223688 16814.67309959554 20115.861087670422 21260.68558031663 19302.449452450925 25356.1364580729 1.0690452698908401 0.8656075813516158 0.9820034268283482 0.8213125309563826 0.9312298232532644 0.6631401880723858 0.7933330505983267 0.8384828507084187 0.761253572064028 1.0 14.630047316769337 -4.0779311538026 0.6042083846198761 0.8122963110569138 1.451188418429193 0.3218326422516179 0.09625762048432164 8.677313899495672 1.2849125056602309 0.04395406937375761 4.661738819379878 8.357354920543731e-05 4.0779311538026 0.6388921073722792 Y(ph)PPY(ph)ERVVLREAS(ph)FK ddPTM_A459_Selumetinib_30min_R1 1 YPPYERVVLREASFK 15 2 O95049-5;O95049;O95049-4;O95049-3 O95049-5 TJP3 Tight junction protein ZO-3 3 Y(1)PPY(1)ERVVLREAS(1)FK 54.812 0.044979000000000005 0.0 331.73 424.73 437.63 651.08 628.36 597.62 443.52 433.94 232.48 319.55 True False 339.45866356578443 375.00241414837984 378.2022497295179 537.3811002852636 571.5249489459684 591.608485395545 410.0649293199994 422.430501564228 394.5015803326065 360.5673551805859 0.9414570084853372 1.0400342925125996 1.0489087386740816 1.4903764652130604 1.5850712515550025 1.640771070634625 1.1372769149182218 1.1715716786192658 1.0941134150511909 1.0 8.494124974645333 -5.649852652556003 6.783199322105092 1.3282189359529346 1.0048390599473644 0.29645940803025406 0.2047459894426009 0.27538514728524394 15.33117261389757 0.060951155109126555 0.10613175403406641 2.2394808208042203e-06 5.649852652556003 -0.32337987600557017 Y(ph)QNHSS(ph)KSSGRS(ph)GRSSY(ph)K ddPTM_A459_Selumetinib_30min_R2 1 YQNHSSKSSGRSGRSSYK 18 3 F8WBF5;P49759;P49759-3;A0A087WVK0;P49759-2 F8WBF5 CLK1 Dual specificity protein kinase CLK1 4 Y(0.674)QNHS(0.648)S(0.674)KS(0.004)S(0.01)GRS(0.407)GRS(0.338)S(0.352)Y(0.894)K 52.853 0.04615 0.0 4339.9 5061.4 4189.5 4177.8 3331.9 3860.3 2515.4 3770.4 1217.2 4304.0 True False 4098.705731996204 5449.593105033912 3919.952131182708 3608.7764328930157 2913.3169344360695 4392.021284685608 2632.3710841705406 3781.371239776678 1460.6740114095908 4179.73233686502 0.9806144034262276 1.3038138966384967 0.9378476455558973 0.8633989313295966 0.6970104063221385 1.050790081926589 0.6297941762808985 0.9046921991691147 0.34946592118507747 1.0 12.029194842125756 -5.600725064376625 2.55165205855184 0.7779847026544864 1.142235911863973 0.32542116475159477 0.2035857147449748 0.30156557609871537 3.942687641018025 0.05525356458892773 0.1161049153231813 2.5076962795325426e-06 5.600725064376625 0.3642512092094867 Y(ph)RFQLQAT(ph)T(ph)K ddPTM_A459_Selumetinib_30min_R1 1 YRFQLQATTK 10 1 P32004-3;P32004-2;P32004 P32004-3 L1CAM Neural cell adhesion molecule L1 3 Y(1)RFQLQAT(1)T(1)K 98.523 0.019384 25785000.0 4351.0 4949.0 4392.6 3941.9 2127.4 4391.9 3577.7 3210.6 2246.7 2238.4 True False 4452.369834427779 4369.568779272319 3796.1090468246707 3253.5211636273284 1934.977045622976 4347.721473526141 3307.831208577203 3125.444458501429 3812.4858075243787 2525.720443862379 1.762811812862049 1.7300286695982445 1.502980686579703 1.2881556909964205 0.7661089533186709 1.7213787393182456 1.309658484419917 1.2374467119258619 1.5094646823598 1.0 11.30247924976826 -5.4914942335146595 2.611179348123933 1.2732416920165375 1.7498148403088802 0.39070418606461477 0.243406228026779 0.29984585919520074 4.026334973176591 0.06865228068446995 0.16103544138434175 3.2248221376502525e-06 5.4914942335146595 0.47657314829234276 Y(ph)RS(ph)TKKLS(ph)QR ddPTM_A459_Selumetinib_30min_R1 1 YRSTKKLSQR 10 3 Q2M2D7;Q86UD7-2;Q86UD7 Q2M2D7 TBC1D28;TBC1D26 TBC1 domain family member 28;TBC1 domain family member 26 3 Y(0.921)RS(0.598)T(0.48)KKLS(1)QR 67.385 0.034763 24492000.0 1447.7 960.99 1146.5 1283.2 1294.4 867.61 886.13 751.57 713.64 722.87 True False 1481.428593266168 848.4768440478696 990.8115972737069 1059.1132086472476 1177.3217485448815 858.882631126851 819.2885006726444 731.6359221565815 1210.994957796634 815.657405850071 1.8162387574011374 1.0402367929996228 1.2147399020316523 1.2984780142386485 1.4434022668106437 1.0529943392492478 1.004451740150375 0.8969892468444849 1.4846857873307062 1.0 9.671819505370465 -6.773793711009498 24.892821300926066 1.0761752093153218 1.332930105240518 0.24797349441020722 0.23602742007995636 335.4878783325906 675972.3464183866 0.08095151599815598 0.07189973493619448 1.683473517662454e-07 6.773793711009498 0.2567548959251962 Y(ph)S(ph)MYLTPKGGVRTSYQPS(ph)SPGRFTK ddPTM_A459_Selumetinib_30min_R2 1 YSMYLTPKGGVRTSYQPSSPGRFTK 25 3 H0YD78;E9PIQ2;H0YF27;E9PRL4;Q14134-2;Q14134 H0YD78 TRIM29 Tripartite motif-containing protein 29 3 Y(0.856)S(0.518)MY(0.451)LT(0.172)PKGGVRT(0.27)S(0.27)Y(0.101)QPS(0.337)S(0.009)PGRFT(0.015)K 44.848 0.048177 0.0 5809.5 4021.6 7038.8 14047.0 10420.0 10552.0 8645.6 12127.0 11942.0 10387.0 True False 5486.631247271121 4330.043788517877 6585.931271265984 12133.774367573415 9110.946444018085 12005.442218481085 9047.637530931403 12162.287562267074 14330.733687358967 10087.100321332948 0.5439255160045932 0.4292654628764204 0.6529062923402842 1.202900137903061 0.9032275038198619 1.1901777355273333 0.8969512786342362 1.2057268367347718 1.4206990344937156 1.0 13.300223890638202 -5.6451079133719615 4.173712086373032 1.1104257172708631 0.4970202621503871 0.7532269440868463 0.15231514078035405 0.10387129653018085 3.226378036848923 0.04261292460126246 0.07667551091052155 2.264081659312195e-06 5.6451079133719615 -0.6134054551204761 Y(ph)S(ph)Y(ph)GHLPT(ph)HS(ph)ITAHPMVTIRISDRQR ddPTM_A459_Selumetinib_30min_R2 1 YSYGHLPTHSITAHPMVTIRISDRQR 26 2 O43149;I3L141;O43149-2 O43149 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 5 Y(0.954)S(0.956)Y(0.954)GHLPT(0.944)HS(0.813)IT(0.301)AHPMVT(0.039)IRIS(0.039)DRQR 49.577 0.01386 15111000.0 0.0 0.0 1567.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 True False 0.0 0.0 1466.929454891574 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Y(ph)S(ph)Y(ph)GHLPT(ph)HSIT(ph)AHPMVTIRISDRQR ddPTM_A459_Selumetinib_30min_R2 1 YSYGHLPTHSITAHPMVTIRISDRQR 26 2 O43149;I3L141;O43149-2 O43149 ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 5 Y(0.809)S(0.823)Y(0.809)GHLPT(0.957)HS(0.761)IT(0.837)AHPMVT(0.002)IRIS(0.002)DRQR 52.483 0.0060646 9909400.0 0.0 0.0 0.0 0.0 0.0 0.0 1638.7 1135.5 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 0.0 1714.902797022448 1138.8041170078561 0.0 0.0 0.0 Y(ph)SNT(ph)TT(ph)LAS(ph)WVR ddPTM_A459_Selumetinib_30min_R2 1 YSNTTTLASWVR 12 0 O00237 O00237 RNF103 E3 ubiquitin-protein ligase RNF103 4 Y(0.689)S(0.319)NT(0.771)T(0.222)T(1)LAS(1)WVR 70.438 0.047375 0.0 0.0 567.89 1054.2 398.06 787.92 344.34 305.66 1233.4 549.41 463.67 True False 0.0 611.4453369458463 986.3739197261749 343.84354130819906 688.934445505828 391.769709392701 319.87379565379956 1236.9889897996375 659.3073517980147 450.282642340661 0.0 1.3579145173516542 2.190566162174944 0.7636171350528419 1.5300044477055703 0.8700528791343191 0.7103844687217573 2.747138960030785 1.46420778818122 1.0 8.814687054992337 -7.729998573442927 24.999976463014498 1.829258839872691 1.1146067726238447 0.16477586112074194 0.6812948871915867 317.2451404942995 252255.74210543887 0.3159164179891971 0.18237272119856154 1.862093253199109e-08 7.729998573442927 -0.7146520672488463 Y(ph)SPESQAQSVHHQRPGSR ddPTM_A459_Selumetinib_30min_R2 1 YSPESQAQSVHHQRPGSR 18 1 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 Y(0.782)S(0.215)PES(0.003)QAQSVHHQRPGSR 91.355 0.012701 1256500.0 1229.5 992.4 3896.0 3830.3 4706.3 2981.7 2242.2 3165.1 3337.9 3477.8 True False 1161.1693120784646 1068.513888931057 3645.335601644067 3308.606532363951 4115.0525191441775 3392.402109822316 2346.466742835013 3174.309916989489 4005.5732687184272 3377.3868775904216 0.3438070183143764 0.3163729615996443 1.0793361062161797 0.9796350410185931 1.2184131307101067 1.004445813516812 0.6947580564146347 0.9398715729168058 1.185997759183627 1.0 11.721691733303375 -5.258294735722906 24.80373570449332 1.0051605822472633 0.3300899015645355 0.8008389780780957 0.13614263450277442 104.3249178469181 822863.1672445473 0.03760760118027248 0.09116536089751921 5.517028967798185e-06 5.258294735722906 -0.6750706806827278 Y(ph)SPPAISPLVSEK ddPTM_A459_Selumetinib_30min_R2 1 YSPPAISPLVSEK 13 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 Y(0.664)S(0.217)PPAIS(0.119)PLVSEK 177.44 0.0014539000000000002 14587000.0 41890.0 45220.0 49673.0 59234.0 52006.0 44503.0 45867.0 41614.0 33859.0 46902.0 True False 39561.9214989564 48688.22859478277 46477.09325987315 51166.22701565054 45472.54134046109 50632.884291988645 47999.9063837363 41735.08985043142 40631.74609950485 45547.81739396915 0.8685799619499369 1.068947567205041 1.0204022040807392 1.1233518957249817 0.9983473180974414 1.1116423835205065 1.0538354882860277 0.9162917618958716 0.8920679063072906 1.0 15.47509430272408 -7.761840554139669 24.99987124144514 0.9281348508259668 1.040692769437797 0.2818460554827572 0.0716036279522108 12.180023706114397 758829.6446865331 0.035326740472004944 0.018611453443325904 1.730451556542719e-08 7.761840554139669 0.11255791861183018 Y(ph)SYLTEPGMIERS(ph)T(ph)GATR ddPTM_A459_Selumetinib_30min_R1 1 YSYLTEPGMIERSTGATR 18 1 Q12955 Q12955 ANK3 Ankyrin-3 3 Y(0.389)S(0.216)Y(0.389)LT(0.006)EPGMIERS(0.965)T(0.969)GAT(0.066)R 62.648 0.028606 106750000.0 193.02 349.61 394.56 271.37 360.54 284.29 267.74 361.98 198.45 222.54 True False 197.51699044846018 308.6774986707206 340.9809191629427 223.98032374579455 327.9292206585071 281.43030071466734 247.54415624128922 352.37911452325017 336.7551557854686 251.10517672316564 0.7865906749752735 1.229275727003535 1.3579207072216668 0.8919781211548846 1.3059436883694246 1.1207666221271657 0.9858186098417145 1.4033128234219376 1.3410920482803466 1.0 7.97214796094031 -4.757719102200396 24.945495071507995 1.1866895648133549 0.7865900884667835 0.33189256933243183 0.16808445161907276 123.98851259922701 831252.2827530975 0.041314376124185655 0.2995365542576969 1.7469517003780284e-05 4.757719102200396 -0.4000994763465714 Y(ph)VKDDK ddPTM_A459_Selumetinib_30min_R1 2 YVKDDK 6 1 A0A1W2PNZ9;Q15652-3;Q15652;Q15652-2;H7BXU7 A0A1W2PNZ9 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 1 Y(1)VKDDK;Y(1)VKDDK 170.31 0.00013391 207625000.0 6863.8 7454.4 7861.8 7766.4 8121.9 7466.7 8671.9 8459.099999999999 4997.6 7057.9 True False 7023.713185370126 6581.635382543454 6794.210741776215 6410.144033383717 7387.275579037913 7391.591777221166 8017.771601213254 8234.737188970737 8480.562189737757 7963.850214767819 0.8819494334970861 0.8264388712809735 0.8531314073659152 0.8049051477006717 0.9276010195846313 0.9281429933871079 1.0067707685342255 1.0340145742194644 1.064882181487011 1.0 12.959250371561309 -6.9497377095192245 1.2262923503114151 1.0386885474023162 0.8420501447950881 0.8830044715731042 0.02948924714040099 0.13647427050938332 0.42372156934223587 0.015824239750249842 0.011968810275987203 1.1226962976987177e-07 6.9497377095192245 -0.1966384026072281 Y(ph)YKINGT(ph)T(ph)T(ph)R ddPTM_A459_Selumetinib_30min_R2 2 YYKINGTTTR 10 1 Q32MC3;Q9UBL9-7;Q9UBL9-5;Q9UBL9-6;Q9UBL9-2;Q9UBL9-3;Q9UBL9;Q9UBL9-4 Q32MC3 P2RX2 P2X purinoceptor;P2X purinoceptor 2 4 Y(0.5)Y(0.5)KINGT(1)T(1)T(1)R;Y(0.5)Y(0.5)KINGT(1)T(1)T(1)R 54.65 0.038757 81204000.0 163337.0 156615.0 176234.0 92163.0 131287.0 318890.0 165476.0 152727.0 172302.0 168311.0 True False 154259.38342981736 168626.8669034036 164895.29630907066 79610.24040995701 114793.55333932849 362814.20290479844 173170.96188447354 153171.41028468407 206767.21452012466 163451.42410550374 0.943762859663106 1.0316634916228031 1.008833647130752 0.48705749029491857 0.7023099001280781 2.2197065879989584 1.05946438112828 0.9371066120893252 1.2650071154269154 1.0 17.318502421385965 YAALSVDGEDENEGEDYAE ddPTM_A459_Selumetinib_30min_R1 2 YAALSVDGEDENEGEDYAE 19 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 ; 245.58 1.3424e-29 35667000.0 15927.2 18310.6 19682.5 20848.2 19399.7 15913.1 18448.7 15475.9 9354.8 13787.599999999999 False True 16298.272771063697 16166.786439633004 17009.724608233522 17207.45323918295 17645.00056029522 15753.028661938764 17057.099705866425 15065.42885919213 15874.41235244093 15557.372762596919 1.04762372283372 1.0391720174309405 1.0933545700677914 1.1060642115970352 1.13418896812175 1.0125764100614882 1.0963997563184418 0.9683787287923369 1.020378735836827 1.0 13.92531082660899 -7.758435760484436 24.99999955934855 0.9957840430224848 1.0759036632834276 0.5128812059756569 0.03544644123480276 64.09709637980176 533514.8638907928 0.01808868613436828 0.009859007381472593 1.7440713160984036e-08 7.758435760484436 0.08011962026094277 YAALSVDGEDENEGEDYAE ddPTM_A459_Selumetinib_30min_R2 2 YAALSVDGEDENEGEDYAE 19 0 E7EX17;P23588;P23588-2 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 ; 197.07 4.1236000000000003e-14 8890700.0 76847.0 84773.0 88273.0 93478.0 95735.0 72421.0 69037.0 73513.0 64258.0 89252.0 False True 72576.1513829149 91274.81651184238 82593.61128437547 80746.13514145583 83707.91341824103 82396.33537761739 72247.35729422033 73726.91065926765 77111.39551853227 86675.06285545473 0.8373360109810115 1.0530689393794674 0.9529108899766733 0.9315959225332622 0.9657669768043674 0.9506348500147864 0.8335426005367308 0.8506127163959454 0.8896606818402718 1.0 16.40332935719873 -7.178850210571242 9.32463714332586 0.8810665829679835 0.953659118345795 0.13586309070995206 0.06438852517526798 0.6296398314532434 67.3525897570695 0.023380525834146834 0.01810365241776641 6.624449434906308e-08 7.178850210571242 0.07259253537781152 YACGLWGLS(ph)PASR ddPTM_A459_Selumetinib_30min_R1 2 YACGLWGLSPASR 13 0 Q15637-6;H7C0N4;H7C561 Q15637-6 SF1 Splicing factor 1 1 YACGLWGLS(1)PASR;YACGLWGLS(1)PASR 130.19 0.0016502 43095000.0 2259.07 3257.6 3168.33 3459.6 3111.5099999999998 2761.1400000000003 2666.54 2621.67 1673.3 2064.12 True False 2311.701935614977 2876.198677582848 2738.0881883909324 2855.445804735051 2830.0744698817093 2733.3654385145337 2465.40074095633 2552.134795215675 2839.467887003399 2329.069908231421 0.9925429577896904 1.234912987118918 1.1756144281946863 1.2260026178876415 1.215109284560173 1.173586687481663 1.0585344528487906 1.0957742342537233 1.2191424039991778 1.0 11.18553822809457 -7.189226244866868 8.957047948078614 1.1014142929934698 1.1776463838516684 0.165159333754619 0.08204702895919769 0.75344016141806 88.69981987001027 0.030645580277656185 0.02371886175445768 6.468055758575395e-08 7.189226244866868 0.0762320908581986 YACGLWGLS(ph)PASR ddPTM_A459_Selumetinib_30min_R2 2 YACGLWGLSPASR 13 0 Q15637-6;H7C0N4;H7C561 Q15637-6 SF1 Splicing factor 1 1 YACGLWGLS(0.921)PAS(0.079)R;YACGLWGLS(1)PASR 155.88 0.00036541 17445700.0 44387.0 40054.0 50113.0 53255.0 54794.0 44527.0 47071.0 47284.0 39422.0 47848.0 True False 41920.1482352394 43126.01300609088 46888.78413890893 46001.577130000864 47910.28785542482 50660.190074138336 49259.89476941704 47421.588611712396 47307.50154271185 46466.50391596599 0.902158430318997 0.9281096999267184 1.0090878415063598 0.9899943669787179 1.031071499204457 1.090251811622337 1.0601162260561472 1.0205542620007235 1.0180990080137466 1.0 15.503903481836483 -5.193517799988944 1.0525647335069224 1.0396364692191282 0.8726963861624472 0.7518866284308711 0.026430001989111374 0.5114753275455576 0.7236086552177108 0.009624878508959916 0.08216271770801617 6.404455317377617e-06 5.193517799988944 -0.16694008305668107 YADEEIPRS(ph)PFK ddPTM_A459_Selumetinib_30min_R2 2 YADEEIPRSPFK 12 1 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 1 YADEEIPRS(1)PFK;YADEEIPRS(1)PFK 79.639 0.022912 56835000.0 121909.0 115998.0 124753.0 121652.0 132579.0 100896.0 116479.0 106986.0 90292.0 143358.0 True False 115133.78582039346 124894.6736076426 116726.52780079648 105082.78773859472 115923.2407487019 114793.50815730373 121895.50429875973 107297.31154751424 108352.9229692692 139218.88205118402 0.8269983505402978 0.8971101603999729 0.838438910591753 0.7548026976682723 0.8326689529519605 0.8245541586456623 0.8755673260897517 0.7707094753717835 0.7782918622305349 1.0 17.086995369489763 -10.661476474682047 4.439980153619644 1.000025648921699 0.8232728636784439 0.6126642352015609 0.04242032242754302 63792441.67093269 1.2425778197489916 17260.693488447567 0.010812286075133622 2.1803365007362724e-11 10.661476474682047 -0.1767527852432551 YADSPGAS(ph)SPEQPK ddPTM_A459_Selumetinib_30min_R1 3 YADSPGASSPEQPK 14 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 YADSPGAS(0.5)S(0.5)PEQPK;YADSPGAS(0.602)S(0.397)PEQPK;YADS(0.001)PGAS(0.5)S(0.5)PEQPK 180.48 7.3786e-05 57556000.0 19928.9 21106.1 24697.5 25481.6 22129.000000000004 20402.600000000002 22954.1 21405.6 12645.0 19175.4 True False 20393.204595110954 18634.988000040303 21343.71515365667 21031.716908872895 20127.435857192275 20197.368368078623 21222.653756548076 20837.853952812 21457.641445740748 21636.749374213123 0.9425262659563716 0.8612656031524613 0.9864566430248671 0.9720368131609773 0.9302430558806739 0.9334751731306752 0.9808614681205963 0.963076920308868 0.9917220500466749 1.0 14.401196149787946 -1.5228787453410366 0.12846840916439806 1.0171134215034243 0.6698238509216716 0.3582881971898615 0.031427736297327424 95.43696616706401 0.8348969185489575 0.17899424154900673 5.989054911641239 0.029999999995807058 1.5228787453410366 -0.3472895705817527 YADSPGAS(ph)SPEQPK ddPTM_A459_Selumetinib_30min_R2 3 YADSPGASSPEQPK 14 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 YADSPGAS(0.599)S(0.401)PEQPK;YADS(0.003)PGAS(0.499)S(0.499)PEQPK;YADS(0.01)PGAS(0.495)S(0.495)PEQPK 144.8 0.00052681 31998000.0 133572.0 116312.0 125629.0 134841.0 128950.0 93729.0 105032.0 101770.0 86737.0 109418.0 True False 126148.60297108148 125232.75639797364 117546.16691451287 116475.42318630069 112750.14817237339 106639.31896285199 109916.19611695965 102066.13385106948 104086.82363427042 106258.81803789406 1.187182440953694 1.17856342382157 1.1062250558122482 1.096148304084873 1.0610898018098074 1.0035808879863715 1.0344195253307005 0.9605427176375199 0.979559396163723 1.0 16.697223044738067 -5.802458224263566 0.5588371983475796 0.9774770528674406 1.231538433745234 0.9357035289869896 0.01922300351771255 0.33636248366225197 0.17021981977998887 0.012876033832139347 0.0490336155237142 1.5759476093017392e-06 5.802458224263566 0.2540613808777934 YADSPGAS(ph)SPEQPKR ddPTM_A459_Selumetinib_30min_R1 2 YADSPGASSPEQPKR 15 1 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 YADSPGAS(0.671)S(0.329)PEQPKR;YADSPGAS(0.5)S(0.5)PEQPKR 125.61 0.00062368 36811000.0 6154.2 6396.299999999999 7703.4 8112.799999999999 6625.0 6413.5 7488.6 6682.4 4494.9 6274.2 True False 6297.5808860113675 5647.418222440802 6657.320591747294 6696.051776117042 6025.769919738747 6348.986012992083 6923.728872893548 6505.161044505687 7627.517005493088 7079.554685883369 0.8895447758273191 0.7977081148482056 0.9403586647931389 0.9458295151627218 0.8511509815376004 0.8968058436856149 0.9779893199637913 0.9188658514746665 1.0774006761615043 1.0 12.789442900242554 -7.7131140522527035 1.0908477173283568 1.02726279747046 0.8841744391976136 0.5283386859449948 0.051332397718963 0.42516082939710814 0.9178283322102482 0.0441896216414301 0.01805744993214104 1.9359134972282446e-08 7.7131140522527035 -0.14308835827284638 YADSPGAS(ph)SPEQPKR ddPTM_A459_Selumetinib_30min_R2 1 YADSPGASSPEQPKR 15 1 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 YADSPGAS(0.563)S(0.437)PEQPKR 88.19 0.028164 0.0 41084.0 36326.0 38619.0 42424.0 41025.0 29491.0 35711.0 36351.0 27999.0 34184.0 True False 38800.71575228277 39112.08739350018 36134.295585187945 36645.778014517986 35871.072731846616 33553.11755735652 37371.632260004066 36456.77539176801 33599.582357424515 33197.01909930158 1.168801199776973 1.1781807058189464 1.0884801276012208 1.103887608248807 1.0805510164797085 1.0107268202903927 1.1257526511104823 1.0981942469808987 1.012126488131924 1.0 15.018766081250245 -1.5228787452803376 0.22049296126069548 1.0228238957035312 1.8728512958871741 0.6094102678821525 0.03747380027817939 38.01034323421721 0.48653938168135563 0.060940152933648614 11.504180053600596 0.029999999999999995 1.5228787452803376 0.850027400183643 YADSPGASS(ph)PEQPK ddPTM_A459_Selumetinib_30min_R2 1 YADSPGASSPEQPK 14 0 A0A0U1RRL5;P32519-2;P32519 A0A0U1RRL5 ELF1 ETS-related transcription factor Elf-1 1 YADSPGAS(0.358)S(0.642)PEQPK 241.41 1.2543e-19 40574000.0 136520.0 107300.0 122400.0 114690.0 112570.0 78284.0 93677.0 95072.0 65833.0 93959.0 True False 128932.76493286042 115529.56497612102 114524.91725904364 99069.0241487145 98427.95021143138 89066.9104086025 98033.1661174539 95348.64377998305 79001.43952770927 91246.15953520019 1.4130212777133027 1.2661307124005914 1.2551204110115248 1.0857336314576227 1.0787078679564663 0.9761168126121846 1.074381284832437 1.0449606237202809 0.8658056397127898 1.0 16.477476218033637 -4.785066186899006 0.48075023731409267 0.9713662174196775 1.7197489379262425 0.8666483172958552 0.05583942366659298 1.6081409076682387 0.2879763131506509 0.03722841660793857 0.6883892002854004 1.6403397647828946e-05 4.785066186899006 0.748382720506565 YAEEDRR ddPTM_A459_Selumetinib_30min_R2 3 YAEEDRR 7 1 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 ;; 118.69 0.014464 20534600.0 67331.0 44749.0 38293.0 42876.8 24452.2 40673.4 140394.0 227325.0 91006.0 119841.0 False True 63589.01256734862 48181.104409286476 35829.27007026598 37036.90587339444 21380.296030558442 46275.79165363619 146922.5991854334 227986.47811432029 109209.74292009637 116380.87894568818 0.5463871139607384 0.4139950208811475 0.3078621711302467 0.3182387537275652 0.1837096971963586 0.39762366526920506 1.262429021987351 1.9589685193966908 0.9383821802124523 1.0 16.828494521375042 -7.276592533462522 4.7425002848378615 1.3827123680811864 0.3467134891943768 0.7311898835439967 0.27436363613676024 0.09041370367482028 5.712984412115809 0.11028726622986337 0.07683760097420174 5.2894128570785954e-08 7.276592533462522 -1.0359988788868095 YAEYS(ph)FTSLPVPESNLR ddPTM_A459_Selumetinib_30min_R1 1 YAEYSFTSLPVPESNLR 17 0 Q5UIP0;Q5UIP0-2 Q5UIP0 RIF1 Telomere-associated protein RIF1 1 YAEYS(0.997)FT(0.001)S(0.001)LPVPESNLR 90.706 0.017029 0.0 253.79 420.48 219.47 245.81 281.82 310.28 286.75 212.04 146.3 239.72 True False 259.7028132106244 371.25000612415124 189.6671794624165 202.88389792517142 256.32943075936225 307.1588649116993 265.1202166362504 206.41601039701084 248.26041467076885 270.4903970705369 0.9601184220336688 1.3725071579060117 0.7011974603037615 0.7500595219735825 0.9476470645001055 1.135562919195243 0.9801465024546283 0.7631177026339419 0.9178160014532011 1.0 8.079433566286575 -5.262570116243583 24.999926162366403 0.8986848327219603 1.1663127783533727 0.32167923763066264 0.15500864042533238 113.89243977338631 2518163.7485832954 0.041565335402769 0.09507723880468988 5.462983436494701e-06 5.262570116243583 0.26762794563141235 YAHVVLR ddPTM_A459_Selumetinib_30min_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 92.692 0.037497 5622300.0 4422.5 4404.6 4829.7 4960.5 4363.7 3845.0 5007.4 4605.1 2565.0 3980.5 False True 4525.535645313001 3888.907384357012 4173.853267643108 4094.24179511742 3969.004105473809 3806.3227909806724 4629.687786519134 4482.957788527045 4352.617659812183 4491.435948353378 1.007592159245224 0.8658494586308725 0.9292915040173955 0.9115663325040682 0.8836826687752054 0.8474623338168994 1.0307812111216772 0.9981123720957344 0.9690926709993297 1.0 12.132961044633806 -7.271699340805259 24.99762369044036 0.9993392632111066 0.9057601507628747 0.5248442945477901 0.0428269861466074 566.3754976048351 1379926.043081998 0.017484276035716357 0.011936982344327463 5.349345628940331e-08 7.271699340805259 -0.0935791124482318 YALPLVGHR ddPTM_A459_Selumetinib_30min_R2 2 YALPLVGHR 9 0 A0A499FI48;P13667 A0A499FI48 PDIA4 Protein disulfide-isomerase A4 0 ; 132.08 0.0048444 3047000.0 41217.0 33399.0 40754.0 47135.0 47864.0 34043.0 33414.0 34713.0 32258.0 39678.0 False True 38926.32414472397 35960.59590528858 38131.93200960022 40715.131687589725 41850.89641041092 38732.11423841471 34967.8172085849 34814.00908295348 38710.501363827265 38532.39304417529 1.0102233749172302 0.933256231038174 0.9896071589917614 1.0566468488191751 1.0861224311303777 1.0051832024554108 0.9074914492981582 0.9034997915400976 1.0046223010195028 1.0 15.23378416652682 -7.135110019844583 6.994660258646227 0.9461543865079498 1.0147179714225913 0.25979518245816535 0.048777826604956394 0.35012420690116147 18.394339021568577 0.02036873299682254 0.015761059841297463 7.326389101732307e-08 7.135110019844583 0.06856358491464154 YALYDASFETK ddPTM_A459_Selumetinib_30min_R1 1 YALYDASFETK 11 0 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 159.4 0.0081142 6684700.0 914.58 1145.1 1373.9 1312.7 964.72 1093.7 930.78 1031.5 515.54 810.46 False True 935.8879345371084 1011.0311596574521 1187.3319262924954 1083.4615874308306 877.4612463351497 1082.6983710001464 860.5705152247226 1004.1412692157928 874.8337264481755 914.4904355489205 1.0233982753196802 1.105567778902557 1.2983535749937096 1.1847708246182866 0.9595083909307984 1.1839362435215186 0.9410382894908763 1.0980336482284363 0.9566351844052463 1.0 9.836824271002627 -6.768106078101302 1.1467448593268927 1.0113496192778728 1.1487818864993482 0.24683639271766722 0.09851162522766821 0.7166337236878083 1.9964043271640206 0.05268790502330187 0.04723189002334617 1.7056657226913353e-07 6.768106078101302 0.1374322672214754 YALYDASFETK ddPTM_A459_Selumetinib_30min_R2 1 YALYDASFETK 11 0 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 171.85 0.0038995 6027100.0 25364.0 22453.0 24838.0 25715.0 21125.0 17770.0 18866.0 18679.0 16458.0 17948.0 False True 23954.370420136805 24175.072902225947 23239.950121569644 22212.572639150723 18471.088640103826 20217.656200000845 19743.306382269806 18733.352797525095 19750.059874941715 17429.79460549569 1.3743346357382715 1.3869970042333972 1.333346183795074 1.274402432266586 1.0597421861919023 1.1599480462968927 1.1327331634788547 1.0747890736255945 1.133120631766621 1.0 14.089267948245478 -6.036937145809614 2.399002584519086 1.1014449680134804 1.37055010982117 0.8785672439187331 0.04598391678346231 0.09344172638639386 1.0712078121053312 0.01395088751178168 0.020775492883010654 9.184655137352722e-07 6.036937145809614 0.26910514180768974 YALYDATYET(ph)K ddPTM_A459_Selumetinib_30min_R1 1 YALYDATYETK 11 0 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;E9PLJ3;Q9Y281-3;Q9Y281 P23528;Q9Y281 CFL1;CFL2 Cofilin-1;Cofilin-2 1 YALYDAT(0.016)YET(0.984)K 107.34 0.024789 6241000.0 527.45 923.79 994.61 989.91 783.57 630.39 844.75 934.51 375.77 658.67 True False 539.7385587609591 815.6322373416799 859.5474250016591 817.0408014120918 712.6962318505192 624.0488489483243 781.0298273878733 909.7237590837141 637.654244845077 743.2167104891147 0.7262196222764615 1.0974352780697143 1.156523276281001 1.0993305046577775 0.9589346173089814 0.8396593350782366 1.0508776462707272 1.22403566314463 0.8579654303324712 1.0 9.53763912942418 -4.754546501756755 24.82674935926004 1.0369889514588082 0.7262190382233353 0.3819065719693009 0.1163860563644766 243.31610350568715 876290.4534663719 0.030029224422603886 0.2895034102315924 1.7597602287033622e-05 4.754546501756755 -0.31076991323547287 YALYDATYETK ddPTM_A459_Selumetinib_30min_R1 1 YALYDATYETK 11 0 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;E9PLJ3;Q9Y281-3;Q9Y281 P23528;Q9Y281 CFL1;CFL2 Cofilin-1;Cofilin-2 0 185.61 0.00026333 27511000.0 1181.4 1262.1 1205.2 1667.0 1684.0 1049.7 1508.0 1249.0 679.41 1174.3 False True 1208.9243213957664 1114.3327452656276 1041.5404596897267 1375.8897434655257 1531.6824973343469 1039.1409710513435 1394.2503459022341 1215.8724626762244 1152.9091478569183 1325.0328436506393 0.9123730986660084 0.8409849994325385 0.7860487871531895 1.038381614507584 1.1559581369427498 0.7842378972194937 1.0522383294748314 0.9176168488973724 0.8700985438825066 1.0 10.371812404930113 -5.760093731433419 24.999001878159067 0.9735685552136485 0.8459205655427704 0.250946937597074 0.10102571206971292 51.66222679434596 959722.4638292432 0.02826720486932965 0.04573413690108399 1.737425809049004e-06 5.760093731433419 -0.1276479896708781 YALYDATYETK ddPTM_A459_Selumetinib_30min_R2 3 YALYDATYETK 11 0 P23528;G3V1A4;E9PP50;E9PK25;E9PQB7;E9PLJ3;Q9Y281-3;Q9Y281 P23528;Q9Y281 CFL1;CFL2 Cofilin-1;Cofilin-2 0 ;; 182.71 0.00048393 60147200.0 261677.0 204811.0 250126.0 248105.0 251372.0 199156.0 213933.0 237291.0 183956.0 218181.0 False True 247134.03991602833 220519.34512883791 234033.16547659755 214312.6709950021 219792.40206580758 226587.93124183282 223881.30840019736 237981.4775243601 220752.3401600911 211881.54762768274 1.166378302797236 1.0407671059507904 1.1045471778780829 1.0114739739941456 1.0373362122690635 1.0694085151765649 1.0566342888603049 1.1231817031209343 1.041866753531535 1.0 17.692898425973254 -3.0777312506873824 0.0077136108399403144 1.1517431203848123e-07 2.2059177610564427 0.22996209772870158 0.043251507334400856 30821.5259449826 24.32136937258277 3188.465173897414 3789.47765509735 0.0008361202645785146 3.0777312506873824 2.205917645882131 YAPNPGGGSYSLQPS(ph)PCLLR ddPTM_A459_Selumetinib_30min_R2 2 YAPNPGGGSYSLQPSPCLLR 20 0 Q9C0H5;Q9C0H5-2 Q9C0H5 ARHGAP39 Rho GTPase-activating protein 39 1 YAPNPGGGSYS(0.002)LQPS(0.998)PCLLR;Y(0.001)APNPGGGS(0.006)Y(0.009)S(0.012)LQPS(0.972)PCLLR 160.47 9.0001e-07 6639800.0 38005.0 32287.0 34409.0 33729.0 37919.0 28641.0 38928.0 33490.0 25935.0 28942.0 True False 35892.8342460692 34763.30908093212 32195.162401686535 29135.05201422964 33155.27621983895 32586.037772888267 40738.22913436863 33587.45035543204 31122.724684446068 28106.369259653235 1.2770356040825757 1.2368480880536548 1.1454756786356883 1.0365996313886434 1.179635687325628 1.1593826819768431 1.4494305101459142 1.195012064530402 1.1073192840002575 1.0 14.778609480033966 -8.504292178347749 2.933606943943537 1.001923690829746 1.2076705017987535 0.3076029422333728 0.10030615130351955 0.3232664881338106 6.599809798471467 0.10403891095824996 0.02784347672113122 3.131178466678099e-09 8.504292178347749 0.2057468109690075 YAPS(ph)EAGLHEMDIR ddPTM_A459_Selumetinib_30min_R1 3 YAPSEAGLHEMDIR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5F3 P21333-2 FLNA Filamin-A 1 YAPS(1)EAGLHEMDIR;Y(0.18)APS(0.82)EAGLHEMDIR;Y(0.004)APS(0.996)EAGLHEMDIR 95.873 0.0080654 16808600.0 5614.25 6415.4 7230.499999999999 7699.5 6410.499999999999 6322.9 5826.099999999999 5797.4 3544.84 4205.96 True False 5745.051101571174 5664.281985561453 6248.637814293534 6354.926862515183 5830.671406865695 6259.297366733861 5386.632586379982 5643.634119390825 6015.334575130067 4745.835935519752 1.2105456614235002 1.1935267174256237 1.316656938670426 1.339053213987518 1.2285868045346018 1.3189030239934663 1.1350229252689183 1.1891759841825944 1.2674973717715092 1.0 12.212446511805139 -10.685686254843008 0.3526870961034284 0.8677326929851145 1.2637908760498953 0.5851575312307095 0.06210944501262983 12.69591135033596 1.0920166506796734 1.6805200941962548 0.05263281503841404 2.0621191015218997e-11 10.685686254843008 0.3960581830647808 YAPS(ph)EAGLHEMDIR ddPTM_A459_Selumetinib_30min_R2 2 YAPSEAGLHEMDIR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5F3 P21333-2 FLNA Filamin-A 1 Y(0.001)APS(0.999)EAGLHEMDIR;YAPS(1)EAGLHEMDIR 94.569 0.0086704 17725900.0 35116.3 46607.0 43331.0 41111.0 59707.0 41581.0 28144.4 29871.0 33930.0 51920.0 True False 33164.67662768687 50181.60703487486 40543.13063522566 35511.61087956933 52206.07287264754 47308.40531526368 29453.17036707059 29957.91966458975 40716.94808341063 50420.9346956394 0.6577560854014688 0.9952534068991538 0.8040931981915834 0.7043029069955046 1.0354047021893573 0.938269105894919 0.584145663797419 0.5941563726540878 0.8075405251646791 1.0 15.621735242455633 -7.248843582846647 24.864269028536743 0.712640329943303 0.861104198258599 0.0889218232867649 0.1567320733061857 1289.5618884659996 2545615.9422793053 0.059149136124639054 0.04549276817332332 5.6384069427040994e-08 7.248843582846647 0.148463868315296 YAPSEAGLHEMDIR ddPTM_A459_Selumetinib_30min_R1 2 YAPSEAGLHEMDIR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5F3 P21333-2 FLNA Filamin-A 0 ; 251.91 1.8423999999999998e-27 27704000.0 7706.299999999999 7971.900000000001 7788.299999999999 7701.3 9871.7 6586.6 7850.7 7461.5 3322.4 5617.0 False True 7885.841796150495 7038.546241964235 6730.691638069616 6356.412526305366 8978.806477990189 6520.344784154302 7258.51537836517 7263.596781632221 5637.870141504871 6337.996664213274 1.2442167792035832 1.1105317050270047 1.0619588483019635 1.0029056282399256 1.4166631750830552 1.0287706241580459 1.1452381190652077 1.1460398555659133 0.889535043989281 1.0 12.62981118506948 -8.252052102962848 24.263439791160938 0.944767525358201 1.1411680865530034 0.32635081300775237 0.11472598874318785 461.3819151027747 1192552.4119264202 0.07839881196436779 0.028697567044164634 5.5969045056109305e-09 8.252052102962848 0.19640056119480243 YAPSEAGLHEMDIR ddPTM_A459_Selumetinib_30min_R2 3 YAPSEAGLHEMDIR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3;H0Y5F3 P21333-2 FLNA Filamin-A 0 ;; 211.83 4.6024e-06 27402600.0 124243.0 91794.0 127631.0 161886.0 158303.0 117092.0 106378.0 111978.0 114050.0 125091.0 False True 117338.0714441357 98834.30463576909 119419.36041412585 139836.84753107373 138415.56189322393 133220.36014465388 111324.78778400813 112303.83744104403 136863.18682325317 121479.2978045497 0.9659100238867293 0.8135896932396287 0.9830428934999433 1.1511166927887568 1.139416875095239 1.0966507261096832 0.9164095429916022 0.9244689380879676 1.1266379481667312 1.0 16.89035094876587 -5.517201573422622 24.690756595102577 1.0490464607814258 0.8918914424080812 0.3574663973466362 0.08602286312645357 232.17966120229892 1009777.0602067938 0.02506515678403362 0.045281796533964365 3.0394739569199826e-06 5.517201573422622 -0.15715501837334467 YASICQQNGIVPIVEPEILPDGDHDLKR ddPTM_A459_Selumetinib_30min_R1 2 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 ; 147.26 3.4132e-14 62746000.0 4462.2 4096.2 5683.7 5307.9 5171.9 4284.4 4756.700000000001 4268.5 2916.8 4015.1 False True 4566.160578070245 3616.6149997282832 4911.884758329325 4380.9749066230725 4704.102558173106 4241.302825923951 4397.898289358858 4155.285513957936 4949.596565356793 4530.477195385918 1.0078762967222676 0.7982856647886096 1.0841870616481313 0.967000763426178 1.0383238575759786 0.9361713221387632 0.9707362160078666 0.9171849530971931 1.0925110869993404 1.0 12.145447302076738 -5.267255195952199 24.998437797029414 0.9945629571241118 0.9030809824327893 0.22255044141608948 0.07229062728325769 629.3981459891243 2705385.4966188036 0.01770230496444901 0.038528427290389536 5.404366634232597e-06 5.267255195952199 -0.09148197469132247 YASICQQNGIVPIVEPEILPDGDHDLKR ddPTM_A459_Selumetinib_30min_R2 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 94.087 1.7271000000000004e-06 5474900.0 18331.0 17498.0 15094.0 21173.0 20094.0 15542.0 13290.0 11843.0 11816.0 17386.0 False True 17312.236404807107 18840.040335062113 14122.86847310462 18289.200874537764 17569.61207736079 17682.769423771148 13908.011333635412 11877.4611692858 14179.530166624814 16884.021005747054 1.0253621692909702 1.1158503255029866 0.8364635692112334 1.0832254276580449 1.040605912026547 1.0473079497918305 0.8237380970386938 0.70347348923831 0.8398195051876758 1.0 14.04337090884446 -7.266922488362509 23.331303816272523 0.817047189264307 1.0237541528163132 0.451086990839076 0.09740211232089814 149.1024368781654 634442.6146964348 0.038845101647711655 0.027081165553025133 5.408508438442657e-08 7.266922488362509 0.20670696355200624 YATS(ph)PKPNNSYMFK ddPTM_A459_Selumetinib_30min_R1 2 YATSPKPNNSYMFK 14 1 Q6P1L5 Q6P1L5 FAM117B Protein FAM117B 1 YAT(0.028)S(0.971)PKPNNS(0.001)YMFK;YAT(0.033)S(0.966)PKPNNS(0.001)YMFK 113.69 0.015255 42786000.0 4886.6 6247.6 6108.7 6801.299999999999 5272.7 4989.9 5631.4 5386.0 3206.6 5311.8 True False 5000.448272331603 5516.128087569561 5279.172092687218 5613.580631213 4795.785215970794 4939.706136466702 5206.61896413385 5243.145783806363 5441.365999202239 5993.621271313522 0.8342950022992925 0.9203331071268511 0.8807984111298827 0.9365924834257613 0.8001481906980388 0.8241605388229927 0.8686933538916786 0.8747876361325898 0.9078594981043482 1.0 12.549212209477826 -8.704837579460792 1.783051626844345 0.999855239476051 0.8677856972525656 0.5150989188573185 0.03909321474577129 0.5910695447277452 3.569742967842634 0.03938914336193206 0.011120182776581965 1.973160534753312e-09 8.704837579460792 -0.13206954222348544 YCAGWADK ddPTM_A459_Selumetinib_30min_R1 1 YCAGWADK 8 0 P00352;Q5SYQ9;Q5SYQ8;Q5SYQ7 P00352 ALDH1A1 Retinal dehydrogenase 1 0 138.9 0.033783 66051000.0 3383.0 4236.4 4159.9 4715.5 4447.2 4157.7 4178.3 3722.7 2271.7 2982.6 False True 3461.817317827899 3740.4003185510737 3595.0084286950655 3892.026445897829 4044.951545216933 4115.877312889558 3863.127467031371 3623.9619029661994 3854.908981596618 3365.445762984246 1.0286355988569542 1.1114130436124883 1.068211667005817 1.1564668457014882 1.2019066210207316 1.2229813233536948 1.1478798765741556 1.0768148287591832 1.1454378567011432 1.0 11.716581891267271 -5.759007557985399 24.99630869346575 1.1460018664740241 1.0736193812867916 0.18033359979441232 0.062248757228321044 100.2459767389639 1030388.703439391 0.017287916761778547 0.028207249332214593 1.7417765611566788e-06 5.759007557985399 -0.07238248518723256 YCDPDSYHR ddPTM_A459_Selumetinib_30min_R1 4 YCDPDSYHR 9 0 P26368-2;P26368;K7ENG2 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 0 ;;; 166.09 0.0013100999999999998 17707700.0 16449.8 19424.800000000003 15826.2 16635.2 20275.8 15991.0 19649.3 15581.800000000001 6859.81 12144.9 False True 16833.048334261122 17150.53538565548 13677.088967093885 13730.17460137835 18441.857469983235 15830.145058666305 18167.137481257807 15168.520047180464 11640.596549300659 13703.816216343912 1.2283474959467946 1.2515152797511122 0.9980496491759608 1.0019234339266023 1.3457461176390033 1.1551632631928046 1.3256991479198836 1.1068829155114956 0.84944196313852 1.0 13.742290088043488 -8.090500167499675 5.225165535141315 0.9313433504861094 1.1820620879077843 0.4439982630002136 0.11545359053606764 0.22078534770917954 9.544277837337683 0.08459092097646634 0.03094946083910451 8.11894935802145e-09 8.090500167499675 0.25071873742167494 YCDPDSYHR ddPTM_A459_Selumetinib_30min_R2 3 YCDPDSYHR 9 0 P26368-2;P26368;K7ENG2 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 0 ;; 152.11 0.0016041 22508000.0 61331.0 54475.0 73430.0 89590.0 94286.0 71313.0 67653.0 72486.0 70097.0 81158.0 False True 57922.468547445606 58653.05733526735 68705.59374453888 77387.68744862964 82440.94975246527 81135.71843504 70798.9985518763 72696.92225929677 84118.35867382376 78814.75766619247 0.7349190717906807 0.7441887670794239 0.8717351391922137 0.9818933628698453 1.0460090494933825 1.0294483017847698 0.8982962156876043 0.9223770320679431 1.0672919788714426 1.0 16.266178171901252 -5.4817182745684105 2.2805175214073103 0.9895739756773096 0.7333454238376002 0.8104291390950014 0.049033748856990106 0.13756934800508488 1.394580792409373 0.015200050371335086 0.03859841396567214 3.2982359830222547e-06 5.4817182745684105 -0.2562285518397095 YCDPDSYHRR ddPTM_A459_Selumetinib_30min_R1 1 YCDPDSYHRR 10 1 P26368-2;P26368;K7ENG2 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 0 94.692 0.031881 2973200.0 1950.0 1543.8 3042.9 3464.7 3191.8 2069.5 2391.8 1945.6 849.06 1431.8 False True 1995.4312059605074 1363.0511783068503 2629.6908934532617 2859.6551854739096 2903.1022535580573 2048.682708955658 2211.3846003507733 1893.9963678005306 1440.7928071111617 1615.5854769130437 1.2351133595068262 0.8436886799151477 1.6277014933792948 1.7700426417164592 1.796935101883385 1.2680744771673416 1.3687821733679755 1.1723281713447042 0.891808466775856 1.0 10.65784136696223 -7.9096861333395845 1.8827586784753445 0.9416575802957529 1.4349762358405267 0.3369105325474513 0.2659056278400757 0.46903850352321813 3.0998005908570967 0.24289880727230495 0.08662201158972511 1.2311582131906431e-08 7.9096861333395845 0.49331865554477383 YCDPDSYHRR ddPTM_A459_Selumetinib_30min_R2 1 YCDPDSYHRR 10 1 P26368-2;P26368;K7ENG2 P26368-2 U2AF2 Splicing factor U2AF 65 kDa subunit 0 106.42 0.016114 1662500.0 13720.0 17809.0 17949.0 22005.0 19125.0 12145.0 10957.0 11755.0 10653.0 18982.0 False True 12957.497325511624 19174.8930350395 16794.180881393586 19007.881039257703 16722.346520330688 13817.86350866688 11466.522210883613 11789.205103854993 12783.897669689763 18433.940338841043 0.7029152252494635 1.0401950251860823 0.9110467199466618 1.031134998262273 0.9071498666563459 0.7495881648022964 0.6220331627483461 0.6395379873837754 0.6934978325146026 1.0 14.170076866128278 -6.786096456947652 3.894475873035813 0.7064873621113796 0.9334339742331064 0.2997298128220416 0.1314722168591396 0.21944313335882024 7.20272476877855 0.04493692140533255 0.04124113597198242 1.6364530243065216e-07 6.786096456947652 0.22694661212172673 YCHDLGER ddPTM_A459_Selumetinib_30min_R1 2 YCHDLGER 8 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 0 ; 117.4 0.012476 7793800.0 3778.0 4307.9 4296.3 4513.7 4566.6 3979.3 4155.6 4381.9 2418.8 3567.8 False True 3866.0200492916915 3803.5290653116213 3712.886057886638 3725.4670276426755 4153.551836298712 3939.2718549153165 3842.1397463072462 4265.677777582826 4104.5269378377 4025.7618833149563 0.9603200987407313 0.9447973267061834 0.9222815868158886 0.9254067020414513 1.0317430480708236 0.9785158608714282 0.9543882270412604 1.0595951527243122 1.0195652541818707 1.0 11.97504612658849 -6.254503172719113 24.791436894928538 1.0061960938389665 0.9375354295515874 0.5849932690433608 0.02850113399890657 384.9488081170395 1375885.5758479973 0.009055777555628976 0.011416738345187541 5.565405684609192e-07 6.254503172719113 -0.06866066428737905 YCHDLGER ddPTM_A459_Selumetinib_30min_R2 1 YCHDLGER 8 0 Q9BQG0;Q9BQG0-2;I3L1L3 Q9BQG0 MYBBP1A Myb-binding protein 1A 0 127.02 0.0065869 2909600.0 22875.0 15157.0 26326.0 25839.0 26317.0 19460.0 20345.0 26374.0 15964.0 23235.0 False True 21603.69907588035 16319.493162563525 24632.21382158157 22319.683625238784 23010.82318303493 22140.438359708307 21291.082812852692 26450.743973549255 19157.246071428443 22564.145178219977 0.9574348553976378 0.7232488992455121 1.0916528690551857 0.9891659289084366 1.0197959196453898 0.9812221196431296 0.9435802971789019 1.1722466667640845 0.8490127111006164 1.0 14.46174450396722 -5.268599306513061 24.997921751304286 1.0087871589556934 0.8403418747189556 0.32197831076807215 0.09598454436925999 521.0959449194821 1819341.1442540796 0.023080420099893504 0.04967019386602534 5.387666359941266e-06 5.268599306513061 -0.16844528423673777 YCRPESQEHPEADPGSAAPY(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 YCRPESQEHPEADPGSAAPYLK 22 1 G8JLH9;P40763;P40763-3 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 1 YCRPESQEHPEADPGS(0.011)AAPY(0.989)LK 64.249 0.017874 7034400.0 36713.0 29498.0 34562.0 38775.0 42603.0 25686.0 35886.0 39596.0 31313.0 38217.0 True False 34672.63843378338 31760.401748980596 32338.318548260348 33493.7781093941 37250.83026434761 29224.013345707466 37554.77010675998 39711.21780452935 37576.47495832114 37113.57591030913 0.9342306038516831 0.8557623718537568 0.8713339460043151 0.9024670161220021 1.0036982249937374 0.7874211155597604 1.0118876768306309 1.0699916898468051 1.012472499258241 1.0 15.179659391620408 -7.441907312358608 9.239278008030466 1.0329244258210042 0.8954757796730255 0.5793570346862842 0.05475176205286124 0.2840884138114654 30.715976196786293 0.022278593645797054 0.014982836598932812 3.6148700339090045e-08 7.441907312358608 -0.1374486461479787 YDCGEEILITVLSAMTEEAAVAIK ddPTM_A459_Selumetinib_30min_R1 1 YDCGEEILITVLSAMTEEAAVAIK 24 0 P63241;P63241-2;Q6IS14 P63241 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 0 138.46 1.199e-06 1295700.0 519.74 331.72 292.17 191.64 449.88 311.92 433.63 438.23 310.75 427.31 False True 531.8489307620075 292.8820681875557 252.4949187749315 158.1736715283342 409.18843343276507 308.7823680007002 400.92093998248424 426.606716828344 527.3200537179862 482.15940085187356 1.1030562295837083 0.6074382614340716 0.5236751960634314 0.32805265488731494 0.8486580012954549 0.6404155295015449 0.8315111958288937 0.8847835717288106 1.0936633254196089 1.0 8.913366366937547 -7.6810388672892085 1.3230763485967716 1.0434636758709466 0.6499923520303412 0.35773054676671023 0.19438982427895657 0.5030256059310314 1.6344293719298923 0.1594639650085322 0.06548742675490044 2.0843043394314027e-08 7.6810388672892085 -0.39347132384060535 YDDYRDYDS(ph)PER ddPTM_A459_Selumetinib_30min_R1 2 YDDYRDYDSPER 12 1 P52756;C9JR02;C9J9P7;C9JFQ5;P52756-4;P52756-2;P52756-5;F8W910;P52756-3 P52756 RBM5 RNA-binding protein 5 1 YDDYRDYDS(1)PER;YDDYRDYDS(1)PER 188.09 0.00049201 25455000.0 3234.6 4252.1 2684.8 2320.42 2747.9 2521.94 3646.2999999999997 3355.3999999999996 1828.3200000000002 3364.2 True False 3309.959886564032 3754.262155252341 2320.2189065507614 1915.202206678029 2499.3529301811473 2496.5715733383113 3371.2566553470288 3266.4038921247425 3102.525504790569 3796.0278400830152 0.8719535330098228 0.9889975293674977 0.6112228372118632 0.5045279664324447 0.6584126975545282 0.6576799956461103 0.8881011408160017 0.8604794352755089 0.8173084169800819 1.0 11.890274857790978 -7.271414144852798 23.801381381078848 0.8798455612630417 0.7109793052705543 0.290261589266656 0.1342295056706282 583.9025858928986 1393275.777459957 0.06278038815266022 0.042950965403505334 5.352859633424298e-08 7.271414144852798 -0.1688662559924874 YDDYRDYDS(ph)PERER ddPTM_A459_Selumetinib_30min_R2 1 YDDYRDYDSPERER 14 2 P52756;C9JR02;C9J9P7;C9JFQ5;P52756-4;P52756-2;P52756-5;F8W910;P52756-3 P52756 RBM5 RNA-binding protein 5 1 YDDYRDYDS(1)PERER 87.669 0.024604 14662000.0 94306.0 103530.0 108770.0 106160.0 121990.0 73456.0 63816.0 59127.0 54571.0 93247.0 True False 89064.85005682945 111470.41809858166 101771.85661982147 91700.82486378541 106664.52559556306 83573.89723282291 66783.57044900497 59299.049780998226 65486.724841137635 90554.71682519799 0.9835473311539973 1.23097307359216 1.1238714027042507 1.0126565250134878 1.1779013764844806 0.9229104806782127 0.7374941117415278 0.6548421977340613 0.7231729846557825 1.0 16.46650216995836 -7.009609627528146 3.299152904418929 0.7524273369404781 1.1080337771557134 0.6640887017627328 0.1088427514329126 0.13419103789278872 3.0392876530694024 0.041406186864433536 0.03347606266055998 9.781160210083394e-08 7.009609627528146 0.35560644021523524 YDDYS(ph)SSRDGYGGSR ddPTM_A459_Selumetinib_30min_R2 1 YDDYSSSRDGYGGSR 15 1 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 YDDYS(0.718)S(0.141)S(0.141)RDGYGGSR 160.03 0.00062915 15620000.0 66470.0 77007.0 73343.0 84281.0 66320.0 54252.0 42339.0 51884.0 40581.0 48837.0 True False 62775.8635004926 82913.1892834681 68624.19122982072 72801.78240716546 57988.28869167752 61724.72054937793 44307.8473931369 52034.97385014141 48698.33392787755 47426.9489162354 1.3236327643881578 1.748229459793162 1.4469450976284284 1.535029852663443 1.2226864687014836 1.3014693536030537 0.934233561416582 1.0971604760416829 1.0268072275508942 1.0 15.533419439090611 -6.66000702597505 1.1258860056176385 1.0182393449307034 1.5429147093143034 0.7503174772729156 0.1234738802311815 0.2201886749242521 0.5941261063952855 0.05838039268356195 0.05824624328256153 2.1877262308352267e-07 6.66000702597505 0.5246753643836 YDDYSS(ph)SRDGYGGSR ddPTM_A459_Selumetinib_30min_R1 1 YDDYSSSRDGYGGSR 15 1 P38159;P38159-2;H3BUY5;Q96E39 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 YDDYS(0.157)S(0.821)S(0.022)RDGYGGSR 129.29 0.0042533 3597300.0 1945.0 2506.8 2528.6 3223.6 2016.2 2185.4 2025.5 1579.1 995.71 1345.5 True False 1990.3147156888153 2213.302690620297 2185.2300086055784 2660.658774466387 1833.8350659890218 2163.4168601844376 1872.7149042605936 1537.2171383603097 1689.6471462189422 1518.2080312798564 1.310963105636433 1.4578388765039483 1.4393482076125097 1.752499472831427 1.2078944572853367 1.424980513612925 1.2335034894275234 1.0125207525509061 1.112922018199681 1.0 10.568153773131286 -7.412411455228875 1.243191297855835 1.0224006366416694 1.4609227873505704 0.6321836817430783 0.13358356673845828 0.30376416001869316 0.8947849510056076 0.09429794508249893 0.0476514107609733 3.868909266381236e-08 7.412411455228875 0.438522150708901 YDEIFYNLAPADGKLS(ph)GSK ddPTM_A459_Selumetinib_30min_R1 2 YDEIFYNLAPADGKLSGSK 19 1 Q9NZN4;Q9NZN4-2 Q9NZN4 EHD2 EH domain-containing protein 2 1 YDEIFYNLAPADGKLS(0.824)GS(0.176)K;YDEIFYNLAPADGKLS(0.925)GS(0.075)K 134.56 0.00011222 344150000.0 11423.0 11331.8 10411.4 11062.900000000001 9285.900000000001 10030.9 10102.5 10473.5 6585.299999999999 9281.5 True False 11689.133674711227 10005.067587989104 8997.58906572654 9130.972191352581 8445.991984558807 9929.998253328493 9340.460291430589 10195.708757277367 11174.773128717794 10472.870934465998 1.1161346060555883 0.9553318904239178 0.8591330039326336 0.8718690651770321 0.8064638662511561 0.948163909921689 0.891871994783334 0.9735352245890383 1.067020991535554 1.0 13.35436936290284 -7.995813340538654 4.319194808950845 1.0318353741763409 0.9152925068759198 0.24074870896562606 0.07924598673136254 0.28786038172690026 13.023995256503081 0.05438762267900023 0.022051786102819187 1.0096867554854446e-08 7.995813340538654 -0.11654286730042107 YDEIFYNLAPADGKLS(ph)GSK ddPTM_A459_Selumetinib_30min_R2 2 YDEIFYNLAPADGKLSGSK 19 1 Q9NZN4;Q9NZN4-2 Q9NZN4 EHD2 EH domain-containing protein 2 1 YDEIFYNLAPADGKLS(0.713)GS(0.287)K;YDEIFYNLAPADGKLS(0.873)GS(0.127)K 103.92 0.00052574 29047000.0 117006.0 95308.0 101735.0 115394.0 107279.0 94543.0 114510.0 119409.0 82657.0 104287.0 True False 110503.27493212928 102617.8171364783 95189.48086069297 99677.1381342467 93801.65293357162 107565.44007409566 119834.9418972605 119756.46042077587 99190.70962954522 101275.96333983322 1.0911105783445738 1.0132494794657492 0.9399020036105018 0.9842131819549162 0.9261985750638438 1.0621023639455098 1.1832515628131062 1.1824766358324434 0.9794101814337633 1.0 16.62793228248254 -6.978206044703087 10.838977105556745 1.104518675454669 0.9894273778891631 0.25852523350025547 0.07499173999695773 0.5326345577208954 259.25451591332654 0.02670045975980659 0.02342000637100448 1.0514629041796069e-07 6.978206044703087 -0.11509129756550585 YDERPGPS(ph)PLPHR ddPTM_A459_Selumetinib_30min_R1 2 YDERPGPSPLPHR 13 1 P08621;P08621-4 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 YDERPGPS(1)PLPHR;Y(0.181)DERPGPS(0.819)PLPHR 112.57 0.002675 1441790000.0 8428.2 9729.6 10333.0 11357.5 9739.3 8581.400000000001 9936.0 9115.3 4836.1 7645.4 True False 8624.560661577616 8590.453908831672 8929.835355106161 9374.125831679481 8858.382034613074 8495.078907287787 9186.519520480511 8873.532633332736 8206.508485231067 8626.761562502428 0.9997448751876511 0.9957912765517279 1.0351318151554219 1.0866332358628745 1.0268490638616257 0.9847355633674842 1.0648862210833738 1.0286052963261367 0.9512849550521881 1.0 13.074603366135374 -8.242757988511613 23.175776142495096 0.975642489698752 1.028705315860186 0.30826284036170926 0.031227257706447485 342.4833916357216 424881.471613801 0.02212167483973442 0.008318341115852555 5.717971830581774e-09 8.242757988511613 0.053062826161433985 YDERPGPS(ph)PLPHR ddPTM_A459_Selumetinib_30min_R2 3 YDERPGPSPLPHR 13 1 P08621;P08621-4 P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 Y(0.007)DERPGPS(0.993)PLPHR;Y(0.001)DERPGPS(0.999)PLPHR;Y(0.001)DERPGPS(0.999)PLPHR 72.428 0.030186 1672888000.0 206690.0 197583.0 229562.0 219948.0 234258.0 176183.0 192559.0 190890.0 167516.0 206998.0 True False 195202.99724562682 212736.9807705215 214792.23084820696 189990.70296853705 204828.41574690846 200450.60901996354 201513.37504841978 191445.45829645923 201023.88078811148 201021.42989460684 0.9710556598267629 1.0582801091508351 1.0685041438657559 0.9451266119644405 1.0189382089974068 0.9971603978991564 1.0024472274128726 0.952363429097245 1.0000121922001346 1.0 17.61698978258069 -5.754035063958522 24.998513870124427 0.9882938936143892 1.0351799746637982 0.2855654007348919 0.03225340610193911 211.3407250985133 713522.2427813828 0.00867519647052067 0.01464661665646278 1.7618337941759097e-06 5.754035063958522 0.046886081049408945 YDGSTIVPGEQGAEYQHFIQQCTDDVR ddPTM_A459_Selumetinib_30min_R1 2 YDGSTIVPGEQGAEYQHFIQQCTDDVR 27 0 Q14019 Q14019 COTL1 Coactosin-like protein 0 ; 123.85 1.0751e-11 10194300.0 2049.83 1933.4499999999998 1966.46 2309.54 1919.5 1768.73 1850.38 1396.7 1187.34 1244.9 False True 2097.587050725143 1707.0807751634804 1699.4255329915864 1906.2221944351338 1745.8815639152497 1750.9381820783476 1710.8043468505161 1359.6549788790103 2014.829260117504 1404.695041352876 1.4932686376574205 1.215267887269947 1.209818133446853 1.3570363234138223 1.2428901024906969 1.2464899003217107 1.2179186915921787 0.9679360564763672 1.4343535079165664 1.0 10.456041240672533 -1.5239986857295482 0.02722267056332153 1.8160945864600337e-06 2.961511987832796 0.3134370533383585 0.13082102124859982 2041.7321461480694 4.28549246305979 155.14912088313568 346.1016507577501 0.02992273691871634 1.5239986857295482 2.9615101717382095 YDGSTIVPGEQGAEYQHFIQQCTDDVR ddPTM_A459_Selumetinib_30min_R2 1 YDGSTIVPGEQGAEYQHFIQQCTDDVR 27 0 Q14019 Q14019 COTL1 Coactosin-like protein 0 69.528 0.0010533 6093800.0 21706.0 17476.0 23322.0 21565.0 23333.0 19607.0 22400.0 20217.0 16546.0 18676.0 False True 20499.66741600257 18816.35300580327 21821.48791107366 18627.809798300033 20401.6999403334 22307.686275375178 23441.644384757947 20275.828122895473 19855.662333867145 18136.775353924524 1.13028181779661 1.037469596365249 1.2031624963779362 1.0270739662808503 1.1248802249689211 1.229969817680304 1.2924924043725077 1.117940081807767 1.0947735717292588 1.0 14.146630352811322 -6.530696541116563 24.756256597750355 1.1650450150817009 1.0991593651570741 0.04302329399610183 0.08697244689541682 382.33965975403885 1210725.6517338601 0.028570850379894014 0.0286256451156932 2.9464797376365607e-07 6.530696541116563 -0.06588564992462675 YDIPATAATATS(ph)PTPNPVPSVPANPPK ddPTM_A459_Selumetinib_30min_R2 3 YDIPATAATATSPTPNPVPSVPANPPK 27 0 P51610;A6NEM2;P51610-4;P51610-3 P51610 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 YDIPAT(0.001)AAT(0.019)AT(0.19)S(0.699)PT(0.091)PNPVPSVPANPPK;YDIPATAAT(0.003)AT(0.093)S(0.884)PT(0.02)PNPVPSVPANPPK;YDIPAT(0.001)AAT(0.018)AT(0.27)S(0.532)PT(0.179)PNPVPS(0.001)VPANPPK 94.087 3.2114e-06 12913600.0 128574.0 115725.0 127247.0 127796.0 133537.0 110396.0 110606.0 111722.0 100071.0 121406.0 True False 121428.37180250241 124600.73538547604 119060.0665560581 110389.96433960351 116760.88822407313 125602.04692489 115749.39816163125 112047.09252342736 120087.99621735854 117900.69332932966 1.0299207610537027 1.0568278427119278 1.0098334725096991 0.9362961423072672 0.990332498706579 1.0653206811434799 0.9817533289504139 0.9503514301688494 1.0185520782470645 1.0 16.847212676722634 -5.514316891392724 24.884463055288172 0.9908348489518557 1.0408634019228473 0.266005809467898 0.0338690018008401 497.4933227197292 1445929.4522419877 0.00954180249548135 0.017653421373867995 3.0597300276015563e-06 5.514316891392724 0.050028552970991624 YDLANQDHMMDAPPLS(ph)PFPHIK ddPTM_A459_Selumetinib_30min_R1 2 YDLANQDHMMDAPPLSPFPHIK 22 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 YDLANQDHMMDAPPLS(1)PFPHIK;YDLANQDHMMDAPPLS(1)PFPHIK 126.29 1.5648e-05 63748000.0 7971.0 7594.0 8752.1 9185.6 7317.299999999999 7088.0 6464.9 7106.7 3993.4 5788.5 True False 8156.708791133955 6704.89094964518 7563.612891844057 7581.507395067147 6655.451506974244 7016.701155389079 5977.2473880791495 6918.2072301850485 6776.508133603886 6531.5103597647385 1.248824290531747 1.0265452522204506 1.1580189688494185 1.1607586878787755 1.018975878530792 1.0742846246732152 0.9151401527126181 1.059204816209499 1.0375101255826489 1.0 12.67320092675328 -6.267830175274318 23.609992154632362 1.0181988067919154 1.140500418538856 0.4960391661889818 0.06449036038576908 213.56866994389654 789001.6692478688 0.01922929790973677 0.022371541594012636 5.397216317805396e-07 6.267830175274318 0.12230161174694065 YDLANQDHMMDAPPLS(ph)PFPHIK ddPTM_A459_Selumetinib_30min_R2 3 YDLANQDHMMDAPPLSPFPHIK 22 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 YDLANQDHMMDAPPLS(1)PFPHIK;YDLANQDHMMDAPPLS(1)PFPHIK;YDLANQDHMMDAPPLS(1)PFPHIK 105.52 3.3932e-05 11393700.0 40635.4 37824.2 45186.9 44143.0 47621.0 38656.0 36348.2 42074.5 33321.3 37489.7 True False 38377.04714439467 40725.194516027885 42279.624049776794 38130.64724907761 41638.424242858484 43980.513115769994 38038.463322591924 42196.92982919156 39986.49107491157 36407.27495106149 1.0541038074390612 1.118600460231383 1.1612960351086121 1.0473359321820341 1.1436841757266558 1.2080144195051243 1.0448039127818018 1.1590246698197684 1.0983104648359772 1.0 15.151939140059497 -8.555419491988255 21.12409025527664 0.9999999983174306 1.1184893854917042 0.31321203437437684 0.05173287701589915 1751.7202826181883 1137143.6597446902 0.04834130104613514 0.012481670266984218 2.7834313089168335e-09 8.555419491988255 0.1184893871742736 YDSS(ph)NQVK ddPTM_A459_Selumetinib_30min_R1 1 YDSSNQVK 8 0 A0A087WZ12;A0A087WT34;A0A087X1H1;A0A0A0MTS6;K7EIE8;O95983-2;O95983 A0A087WZ12 MBD3 Methyl-CpG-binding domain protein 3 1 Y(0.185)DS(0.23)S(0.585)NQVK 100.82 0.017533 17202000.0 2676.3 2697.1 3577.5 3299.3 2546.4 3094.4 2569.9 3058.9 1923.8 2175.2 True False 2738.652582826722 2381.3222781522286 3091.695149800862 2723.13919053138 2316.0785696034336 3063.2731454904037 2376.0503739616406 2977.7680352924763 3264.548091207281 2454.4081082422495 1.1158097847012238 0.9702226252249623 1.2596499903249638 1.1094891600898373 0.9436403676412713 1.2480700072671287 0.9680746922170471 1.2132326426451698 1.3300754997689532 1.0 11.261159438628267 -7.862112620293093 19.33047680638135 1.2037908082902369 1.0912433101237986 0.09255420789556335 0.12769780831121666 5.327488847723951 1008.6458507901312 0.06614621737251448 0.03177551160973451 1.373685707654625e-08 7.862112620293093 -0.11254749816643828 YEAVS(ph)PERLELER ddPTM_A459_Selumetinib_30min_R1 1 YEAVSPERLELER 13 1 Q92585 Q92585 MAML1 Mastermind-like protein 1 1 Y(0.002)EAVS(0.998)PERLELER 78.508 0.022525 13322000.0 1859.2 2184.7 2419.2 2979.2 2389.0 1823.6 2375.7 1923.3 1345.8 1797.4 True False 1902.5157426265537 1928.9143083605236 2090.6859277143935 2458.9386465101925 2172.9153718122084 1805.2562396963217 2196.4990363129555 1872.2878362411395 2283.7243066570104 2028.113798158613 0.9380714949791803 0.9510878088358968 1.0308523760415178 1.2124263681568257 1.0713971640965438 0.8901158511595204 1.0830255374758677 0.9231670520367483 1.126033612477995 1.0 10.985922889386487 -5.267173438228004 5.197774335992083 1.04289078834987 0.9430530282774341 0.16493006569628677 0.08814559166267583 0.30621174206467644 28.08176801282545 0.02370797140903105 0.05719101420283369 5.4053841242714406e-06 5.267173438228004 -0.09983776007243583 YEAVS(ph)PERLELER ddPTM_A459_Selumetinib_30min_R2 1 YEAVSPERLELER 13 1 Q92585 Q92585 MAML1 Mastermind-like protein 1 1 Y(0.002)EAVS(0.998)PERLELER 64.945 0.042565 8371700.0 14727.0 14897.0 15453.0 16077.0 14531.0 11504.0 8826.0 8185.1 8727.6 13314.0 True False 13908.532296852016 16039.551998595285 14458.770803954261 13887.28486562809 12705.48587121178 13088.57157708552 9236.42648838722 8208.917285883752 10473.36386951885 12929.590226073631 1.075713309831294 1.2405305750719113 1.1182698408180722 1.0740699916091063 0.9826673273519585 1.0122959311340967 0.7143634351041669 0.6348938475505406 0.8100306109004453 1.0 13.6583889324873 -6.833871256393966 1.369020387606878 0.762899497627951 1.1359230980551238 0.6417052336627314 0.10759820540234737 0.24025941965718822 0.9380115996272658 0.05216023886164576 0.04419259403777757 1.465982356914362e-07 6.833871256393966 0.37302360042717286 YEDDGIS(ph)DDEIEGK ddPTM_A459_Selumetinib_30min_R1 1 YEDDGISDDEIEGK 14 0 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 YEDDGIS(1)DDEIEGK 251.68 1.3797e-27 3512000.0 1280.4 1654.1 1026.4 1175.0 1148.1 1006.7 1258.0 1086.6 692.2 1227.1 True False 1310.2308287753008 1460.4372030297716 887.0205176116291 969.8083074816993 1044.254557713518 996.5735120104669 1163.1080471783887 1057.7798382257695 1174.612843712278 1384.6102379661936 0.9462813381329996 1.0547641227721656 0.6406283106172486 0.7004197144361849 0.7541866505677349 0.7197502117811142 0.8400256009133936 0.7639549450244612 0.8483346515172576 1.0 10.43526420542065 -5.249523101161372 24.995793479440295 0.7707227620156433 1.0005227512854968 0.44074505487833804 0.09698626358007431 617.8743017410496 1296058.3643104562 0.02370659104632395 0.06163680885480569 5.629591714541099e-06 5.249523101161372 0.22979998926985357 YEDDGIS(ph)DDEIEGK ddPTM_A459_Selumetinib_30min_R2 2 YEDDGISDDEIEGK 14 0 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 YEDDGIS(1)DDEIEGK;YEDDGIS(1)DDEIEGK 213.99 1.5491e-06 8345300.0 61406.0 50549.0 51693.0 58775.0 58395.0 44114.0 61895.0 64654.0 51840.0 46545.0 True False 57993.300347694385 54425.94575934706 48367.128659082875 50769.7436074697 51058.8980420764 50190.303072979026 64773.24014261579 64842.13243595411 62209.448530622096 45201.12491156655 1.2830056876052311 1.2040838776872997 1.0700425875176875 1.1231964626278184 1.1295935254259768 1.1103773008121705 1.4330006226469139 1.434524750497119 1.3762809808899972 1.0 15.46407105670637 -7.253041180838464 24.937232738905227 1.3471619857328054 1.149446121451449 0.24618671713066242 0.12888281677279173 658.6951442573834 1955903.2130503263 0.0481506727536866 0.03665735293291479 5.584172417717492e-08 7.253041180838464 -0.19771586428135635 YEDDGIS(ph)DDEIEGKR ddPTM_A459_Selumetinib_30min_R1 1 YEDDGISDDEIEGKR 15 1 I3VM54;Q9Y2K7-3;Q9Y2K7 I3VM54 KDM2A Lysine-specific demethylase 2A 1 YEDDGIS(1)DDEIEGKR 123.63 0.0025503 18520000.0 587.68 554.88 716.46 670.82 739.63 593.55 687.02 825.73 457.12 586.51 True False 601.3718005737801 489.9143916432866 619.1686672330746 553.6738798509563 672.7305970922828 587.5794259002804 635.1975282770246 803.828958050952 775.6992532761578 661.794271591192 0.9086990117455467 0.7402820070735212 0.9355908532486538 0.8366253738034399 1.0165252646790004 0.8878581322372701 0.9598111611782024 1.2146206042525232 1.1721153938233664 1.0 9.370238993690593 -7.611696751964561 4.596615187342922 1.1432764683511967 0.8890125797388126 0.6197508879606253 0.0841054686910193 0.13149101689327142 4.942095575215181 0.04135830278192469 0.023088961384344985 2.445137284640062e-08 7.611696751964561 -0.254263888612384 YEDFKEEGSENAVK ddPTM_A459_Selumetinib_30min_R2 1 YEDFKEEGSENAVK 14 1 J3KQ32;Q9NTK5;Q9NTK5-2 J3KQ32 OLA1 Obg-like ATPase 1 0 120.84 0.005658399999999999 2652600.0 18134.0 15219.0 18138.0 18263.0 13733.0 11364.0 15538.0 16332.0 11393.0 18123.0 False True 17126.184876153628 16386.2483632021 16971.02082716122 15775.54789456774 12007.737765422291 12929.28784787899 16260.547787962902 16379.523416091843 13671.918347017307 17599.74190079108 0.9730929562884006 0.9310504924203215 0.9642766878529282 0.8963510932997635 0.6822678328528535 0.7346294008605796 0.9239083095435631 0.9306683875492293 0.77682493437036 1.0 14.103266651526848 -6.003446470205027 22.72347171316299 0.8323964521735794 0.9497450105429855 0.23969940487335095 0.09078200045213553 64.43293035687816 424849.2346953947 0.026926194347476107 0.03889305589704325 9.920956143411012e-07 6.003446470205027 0.11734855836940616 YEDKPEPEVDALGS(ph)PPALLK ddPTM_A459_Selumetinib_30min_R1 2 YEDKPEPEVDALGSPPALLK 20 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 YEDKPEPEVDALGS(1)PPALLK;YEDKPEPEVDALGS(1)PPALLK 159.66 5.7793e-07 54922800.0 8274.7 9429.6 7899.9 8775.7 8503.0 8362.9 9993.0 10124.2 5810.3 8316.3 True False 8467.484410236624 8325.578048297893 6827.136971044537 7243.188735291189 7733.9051513265795 8278.77681890566 9239.21996458954 9855.673327963674 9859.654732478251 9383.778112621834 0.9023534346839754 0.8872309157757483 0.7275467182947946 0.7718840586766003 0.8241781783953245 0.8822434545601766 0.9845948885089414 1.0502884029948563 1.0507126888706297 1.0 13.19595318468614 -7.22623103991488 1.9790307409183103 1.0377850229437147 0.8181697322581927 0.7865094491628803 0.04937397847178541 0.16393168463009172 1.2551774143414591 0.027375261071798506 0.01787892417922209 5.939760857675381e-08 7.22623103991488 -0.219615290685522 YEDKPEPEVDALGS(ph)PPALLK ddPTM_A459_Selumetinib_30min_R2 2 YEDKPEPEVDALGSPPALLK 20 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 YEDKPEPEVDALGS(1)PPALLK;YEDKPEPEVDALGS(1)PPALLK 150.94 6.9298e-06 25193000.0 64973.0 56932.0 58335.0 63235.0 56950.0 49625.0 56232.0 61705.0 47733.0 63678.0 True False 61362.06076752669 61298.50133476717 54581.78961034564 54622.28391354056 49795.43186054029 56460.39329910197 58846.89942159414 61884.551334187374 57280.933771454154 61839.45068468656 0.9922801720928273 0.9912523584228191 0.8826370384279925 0.8832918680350891 0.8052372928479333 0.9130157637878789 0.9516077321198865 1.0007293184043755 0.9262846473770304 1.0 15.916239883514693 -7.366313660133792 3.7310249410400247 0.9728356430171011 0.9075284464384633 0.22164367030685017 0.0544413101151559 0.41819155348140946 10.571955560004819 0.027189869667559385 0.01763336850210638 4.302157838820091e-08 7.366313660133792 -0.06530719657863782 YEDSDKPFVDS(ph)PASR ddPTM_A459_Selumetinib_30min_R1 1 YEDSDKPFVDSPASR 15 1 O94913;E9PKN0;E9PQ01 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 YEDSDKPFVDS(0.998)PAS(0.002)R 145.94 0.0016699000000000002 0.0 729.77 778.46 1005.7 1058.0 837.96 852.85 909.36 653.6 611.45 744.83 True False 746.7722211147693 687.3175413037645 869.1314639146682 873.2401611196916 762.1666659538539 844.2711033258437 840.7662430700639 636.2644048079908 1037.5859914589316 840.436185758585 0.8885531510530169 0.8178105047718593 1.0341433158666087 1.039032083478768 0.9068703595454016 1.004563008628427 1.0003927214428314 0.7570645048245906 1.2345803394012569 1.0 9.71499446969451 -5.258386153000265 24.93416022092112 0.9870664890012125 0.8531818218873883 0.2008071099971137 0.1134307492181878 401.5871346594088 3279515.975094546 0.027567133747982114 0.066661192570631 5.515867777154386e-06 5.258386153000265 -0.13388466711382419 YEDSDKPFVDS(ph)PASR ddPTM_A459_Selumetinib_30min_R2 1 YEDSDKPFVDSPASR 15 1 O94913;E9PKN0;E9PQ01 O94913 PCF11 Pre-mRNA cleavage complex 2 protein Pcf11 1 YEDS(0.004)DKPFVDS(0.985)PAS(0.011)R 62.035 0.042646 6047900.0 33320.0 31903.0 39230.0 36043.0 38965.0 26011.0 38723.0 31588.0 29471.0 48545.0 True False 31468.20779052823 34349.85751568672 36705.98451039446 31133.88122235698 34069.868348480304 29593.779145651228 40523.69622816885 31679.91585032509 35366.02348854097 47143.37971494248 0.6675000388348086 0.7286252645310293 0.7786031619358041 0.6604083417568138 0.7226861662122536 0.6277398719521851 0.8595840279844114 0.6719907660817089 0.7501800613868892 1.0 15.524767568837701 -14.522878745257264 0.3155518396219799 3.5906155011856473 0.7068942519357435 0.6471979206952326 0.06294103071313928 188.1866791162238 1.6842969421731386 324.73745547931816 0.055240814526145085 3.0000000001593845e-15 14.522878745257264 -2.883721249249904 YEESNLGLLES(ph)SVGDSR ddPTM_A459_Selumetinib_30min_R1 1 YEESNLGLLESSVGDSR 17 0 Q86TU7 Q86TU7 SETD3 Histone-lysine N-methyltransferase setd3 1 YEESNLGLLES(0.866)S(0.133)VGDSR 101.5 0.0059719 0.0 146.54 264.26 171.82 271.79 344.18 263.91 234.74 150.37 131.07 180.68 True False 149.95409688279636 233.320316348859 148.487787739702 224.3269786301709 313.0489797699145 261.25530501110785 217.0333728097417 146.38169912940265 222.4162170259581 203.87203797223677 0.7355304747736767 1.1444449109820174 0.7283381733787495 1.100332251844756 1.5355169982287882 1.2814670791032439 1.0645568414796405 0.7180077296786372 1.0909598944424477 1.0 7.67152010615366 -5.8962313505792405 9.208569048319827 1.1257694046095839 0.89770245457631 0.19721427791954427 0.2225045286069218 0.5355654821085594 43.411253591716914 0.06850274803649603 0.10179589873944409 1.2698974450444284e-06 5.8962313505792405 -0.22806695003327382 YEEVSVSGFEEFHR ddPTM_A459_Selumetinib_30min_R1 1 YEEVSVSGFEEFHR 14 0 I3L0K2;I3L3M7;I3L2R6;Q9BRA2 I3L0K2 TXNDC17 Thioredoxin domain-containing protein 17 0 204.35 3.4876e-05 9527600.0 4846.6 5608.7 5513.8 5536.2 5773.9 5288.9 5211.9 4643.7 2338.7 3917.6 False True 4959.51635015805 4952.030796586108 4765.056245135427 4569.406597344836 5251.651764464843 5235.698467936978 4818.762186875236 4520.5339911365745 3968.6030881102324 4420.462120655497 1.1219452208364629 1.1202518337272365 1.0779543213072103 1.0336943225897959 1.1880322964256262 1.1844233306450305 1.0901037166133836 1.0226383277923528 0.897780136960373 1.0 12.109981483312273 -7.88685581790775 2.8185082222680617 0.9503411946190788 1.1186622266770758 0.6587255348820449 0.049120582237504866 0.1709650132968961 2.658259762809346 0.03552484972038761 0.014360447774703104 1.2976099950173856e-08 7.88685581790775 0.16832103205799698 YEGSYALTSEEAERS(ph)DGDPVQPAVLQVHQTS ddPTM_A459_Selumetinib_30min_R2 1 YEGSYALTSEEAERSDGDPVQPAVLQVHQTS 31 1 O95810 O95810 SDPR Serum deprivation-response protein 1 Y(0.006)EGS(0.025)Y(0.034)ALT(0.075)S(0.075)EEAERS(0.78)DGDPVQPAVLQVHQT(0.002)S(0.001) 43.807 0.01922 6087500.0 14748.0 10219.0 15942.0 21184.0 19780.0 13324.0 12591.0 14061.0 9834.9 15013.0 True False 13928.365200921678 11002.764440736066 14916.3090763372 18298.70265556169 17295.059564556403 15159.260056770472 13176.506448593187 14101.915182076144 11802.154810065882 14579.535681541485 0.9553366791067136 0.7546718003280575 1.0230990480185242 1.255095021903124 1.1862558549414521 1.0397628832558057 0.9037672211520006 0.9672403490825818 0.8095014181424225 1.0 13.831657154042547 -10.222661724189443 7.317411688658705 0.9999758984438186 0.9945301266345715 0.0 0.144845230721287 0.0 0.0 0.15624624596916317 0.03789528092571162 5.988778847158903e-11 10.222661724189443 -0.005445771809247102 YEPQS(ph)PGYEPR ddPTM_A459_Selumetinib_30min_R1 2 YEPQSPGYEPR 11 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 YEPQS(1)PGYEPR;Y(0.002)EPQS(0.998)PGYEPR 175.6 7.509999999999998e-05 118566000.0 4258.45 5797.0 5165.8 6004.4 5285.9 4907.1 5154.4 4094.8 2360.3199999999997 3789.45 True False 4357.663599498732 5118.284545047816 4464.312733708257 4955.844256547329 4807.7912783014435 4857.739029290316 4765.59945816875 3986.1926022150546 4005.2906490479095 4275.862819868786 1.0191308241344508 1.197017949515247 1.0440729559806725 1.1590278887149634 1.124402601496224 1.1360839283051147 1.1145351614238628 0.9322545577683851 0.9367210356787874 1.0 12.061999853279499 -7.756994588400093 24.98237611922591 0.9508658269226468 1.1170546065021962 0.6614124555551664 0.05143380437542669 56.38931575879911 316947.3998375583 0.023154222242848126 0.01277498030027581 1.7498684930213752e-08 7.756994588400093 0.16618877957954947 YEPQS(ph)PGYEPR ddPTM_A459_Selumetinib_30min_R2 2 YEPQSPGYEPR 11 0 Q9H5H4;H3BS42 Q9H5H4 ZNF768 Zinc finger protein 768 1 Y(0.078)EPQS(0.921)PGYEPR;Y(0.004)EPQS(0.991)PGY(0.005)EPR 107.37 0.010584 158814000.0 392830.0 400350.0 410820.0 432650.0 467300.0 397010.0 302420.0 425890.0 366050.0 445310.0 True False 370998.08122308494 431055.5576718547 384388.2884669957 373722.32363711996 408593.59628499474 451694.5238020446 316483.1292338617 427129.26939011546 439270.2282915543 432452.74324567046 0.85789276867259 0.9967691601090802 0.888856168611769 0.8641922833746795 0.9448283139988739 1.0444945276840183 0.7318328630744099 0.9876900448923022 1.0157646937205598 1.0 18.722182963694735 -7.974458027212319 24.99962319410784 1.0058310287764274 0.9087593478958222 0.23738506892208822 0.0799225654560953 311.31295538084896 304702.3945288496 0.04272423877899349 0.02052310301526906 1.0605764337994824e-08 7.974458027212319 -0.09707168088060514 YEQGTGCWQGPNR ddPTM_A459_Selumetinib_30min_R1 2 YEQGTGCWQGPNR 13 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 ; 164.48 0.0040042 5160100.0 860.46 957.04 1063.13 941.25 939.2099999999999 1037.5 838.97 798.54 544.75 750.62 False True 880.5070438362974 844.9893118841746 918.7627853550777 776.8783569507648 854.2586213309934 1027.0636919746287 775.6858174413783 777.3601251765185 924.4009630341858 846.969388657961 1.0395972459305496 0.9976621625287736 1.0847650430564848 0.9172449056060258 1.0086062528004494 1.2126337807816532 0.9158368978015453 0.9178137198184463 1.091421927891534 1.0 9.726166018093219 YEQGTGCWQGPNR ddPTM_A459_Selumetinib_30min_R2 2 YEQGTGCWQGPNR 13 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 ; 184.87 1.1732e-13 6434900.0 10340.0 6501.5 9232.6 10731.2 11206.9 7763.9 8355.3 7076.2 7726.0 8819.0 False True 9765.34419429958 7000.144144382573 8638.584567694823 9269.592047647458 9798.989031042825 8833.306751332957 8743.838005712863 7096.790570472026 9271.415882476582 8564.37255548621 1.1402287944659817 0.8173563327646676 1.0086652013008324 1.082343392652798 1.1441572593389504 1.031401505960232 1.0209548859608741 0.8286410387327122 1.0825563486886671 1.0 13.064131839874277 -10.022984566892418 7.214563946364249 0.9999899602763324 1.011836291650461 0.0 0.10762202767850196 0.0 0.0 0.1051574000926255 0.02550441575866067 9.484521669394668e-11 10.022984566892418 0.011846331374128716 YES(ph)ASMSSTCEPCK ddPTM_A459_Selumetinib_30min_R2 1 YESASMSSTCEPCK 14 0 A0A5H1ZRS1;Q15154-5;Q15154;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 YES(0.997)AS(0.003)MSSTCEPCK 113.35 0.0033243 4348800.0 20131.0 22225.0 29223.0 26944.0 23474.0 17775.0 21079.0 21986.0 20502.0 26140.0 True False 19012.199610778014 23929.58603536149 27342.823995596675 23274.180719007458 20524.986259777386 20223.34490461537 22059.215267246112 22049.97562002176 24602.97287374256 25385.27028012355 0.74894611721603 0.9426563424892171 1.0771137629763932 0.9168380112632065 0.8085392053457188 0.796656670638251 0.8689769706536585 0.8686129939410849 0.9691830184296474 1.0 14.63170400025193 -8.381350305948786 3.9395559927873856 0.998003047107978 0.8832485998992847 0.197206313130875 0.08597177360274284 0.4258120809696485 10.72465856264587 0.08994392886820343 0.023785197783620454 4.155752684092662e-09 8.381350305948786 -0.11475444720869332 YES(ph)SEIR ddPTM_A459_Selumetinib_30min_R2 2 YESSEIR 7 0 A6PWM2;Q6UXH1-3;Q6UXH1-2;Q6UXH1-4;Q6UXH1;Q6UXH1-6;Q6UXH1-5 A6PWM2 CRELD2 Cysteine-rich with EGF-like domain protein 2 1 YES(0.805)S(0.195)EIR;YES(0.662)S(0.338)EIR 89.355 0.031073000000000007 62149000.0 174163.0 115755.0 165774.0 182490.0 184430.0 131077.0 142436.0 135002.0 114589.0 128374.0 True False 164483.71768972895 124633.03628901132 155108.28132108395 157634.54718719068 161260.25457488044 149131.66695146367 149059.55623157974 135394.8334692157 137510.00188417174 124667.50906429125 1.3193791945013067 0.9997234822806786 1.2441756676239863 1.2644396953972847 1.2935227132172684 1.1962352345915261 1.1956568102656921 1.086047475283976 1.1030139522019133 1.0 16.927725992374846 -8.055566573333454 1.1795425226217078 1.0178071805254145 1.2172547286443818 0.4217790856669311 0.08425387291608624 0.4814803210062188 1.231817215712055 0.07838317003281718 0.02689405103818717 8.799002207706771e-09 8.055566573333454 0.19944754811896725 YESAS(ph)MSSTCEPCK ddPTM_A459_Selumetinib_30min_R2 1 YESASMSSTCEPCK 14 0 A0A5H1ZRS1;Q15154-5;Q15154;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 YES(0.001)AS(0.985)MS(0.005)S(0.005)T(0.003)CEPCK 105.0 0.009639299999999998 0.0 6341.1 7073.2 8779.8 9958.7 8476.1 7828.5 6520.7 7154.8 5844.0 8370.3 True False 5988.687047434532 7615.691696077338 8214.917226723455 8602.30788028428 7411.256540704571 8906.804814952546 6823.925470521924 7175.619283459097 7012.963295002994 8128.627690348819 0.7367402316315884 0.936897590366884 1.0106155109646722 1.0582730822446038 0.9117475695810269 1.09573290280322 0.8394929292461041 0.8827590039557063 0.862748739658668 1.0 12.988796095579842 -10.307595279720193 13.109702936899579 0.999999999555852 0.9335453314858717 0.040938634988411216 0.10171407124964908 0.0 0.0 0.1008137615416653 0.024450928667771626 4.9249828246388465e-11 10.307595279720193 -0.06645466806998024 YESGPDGGEEDGTGS(ph)LKR ddPTM_A459_Selumetinib_30min_R1 1 YESGPDGGEEDGTGSLKR 18 1 Q07866-6;G3V5R9;G3V3H3 Q07866-6 KLC1 Kinesin light chain 1 1 YESGPDGGEEDGT(0.368)GS(0.632)LKR 107.73 0.0069192 0.0 455.25 694.55 562.76 417.52 563.14 480.55 392.29 383.71 515.97 495.54 True False 465.8564392377031 613.2317631124647 486.34028301940833 344.60796982107144 512.2040864304424 475.71610330448954 362.699249465509 373.53276433426254 875.5634050422191 559.1473859683541 0.8331549979991663 1.0967265134405395 0.8697890667540983 0.6163097216743049 0.9160448555855923 0.8507883882540649 0.6486648396600688 0.6680399009419732 1.5658901874787143 1.0 9.127084803754018 -8.251131805403144 24.995883991551434 1.2829451169700132 0.8165626036473644 0.5078386257332281 0.18523880263787604 494.95551714725104 1200275.1346900605 0.12755275340733802 0.04702729874400066 5.608777276472179e-09 8.251131805403144 -0.4663825133226488 YESGPDGGEEDGTGS(ph)LKR ddPTM_A459_Selumetinib_30min_R2 2 YESGPDGGEEDGTGSLKR 18 1 Q07866-6;G3V5R9;G3V3H3 Q07866-6 KLC1 Kinesin light chain 1 1 YESGPDGGEEDGT(0.012)GS(0.988)LKR;YESGPDGGEEDGT(0.032)GS(0.968)LKR 82.03399999999998 0.0050993 12886500.0 58714.0 49798.0 45957.0 50885.0 47251.0 38252.0 41614.0 40297.0 30914.0 50795.0 True False 55450.91093076452 53617.34647419268 43000.176654198294 43954.37521847886 41314.90695070044 43520.865782916866 43549.13345657664 40414.25759847255 37097.663809329664 49328.41636874043 1.1241169900176227 1.086946438202913 0.8717120844253909 0.8910558751756905 0.8375478069651112 0.8822676458451274 0.8828406963450353 0.8192895814122099 0.7520546277426934 1.0 15.590131351584102 -5.238927625062288 3.6227427758165263 0.859833279680645 1.1178685186728243 0.7197181905844444 0.05961129325821197 0.11029882645219068 3.1374013691641154 0.015341817742429752 0.043400062693440745 5.768625892171365e-06 5.238927625062288 0.2580352389921793 YESLTDPSK ddPTM_A459_Selumetinib_30min_R1 2 YESLTDPSK 9 0 P07900;P07900-2;G3V2J8;P08238;Q58FF7;Q58FF6;Q58FF8 P07900;P08238;Q58FF6;Q58FF8 HSP90AA1;HSP90AB1;HSP90AB3P;HSP90AB4P;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 4;Putative heat shock protein HSP 90-beta 2 0 ; 146.79 0.023661 10876100.0 11348.5 11977.8 11021.5 10614.7 10617.599999999999 9449.900000000001 10742.4 11541.2 8963.099999999999 11440.900000000001 False True 11612.89796966299 10575.433607671845 9524.840836765947 8761.04190759659 9657.239954689529 9354.842585822693 9932.09211924414 11235.089884898993 15209.726061077014 12909.450958803205 0.8995655978493748 0.8192008816966961 0.7378192044852824 0.6786533320088461 0.7480751881321543 0.7246506931763387 0.7693659591674 0.8702995906450667 1.1781853550251264 1.0 13.65614002342804 -8.065973185678818 3.8148629253537023 1.08525911894133 0.7648505897549941 0.7680439618646338 0.06946327623471203 0.11033404008614178 3.056700390914853 0.05324945767656515 0.018967549640126116 8.590665605757073e-09 8.065973185678818 -0.320408529186336 YESLTDPSKLDSGK ddPTM_A459_Selumetinib_30min_R1 2 YESLTDPSKLDSGK 14 1 P07900;P07900-2;G3V2J8;P08238;Q58FF7;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 ; 116.9 0.007279099999999998 84139000.0 8363.0 8013.3 11874.8 12207.099999999999 10321.4 9393.0 8782.7 10392.9 6634.3 7888.1 False True 8557.84162843473 7075.099110717898 10262.267383607345 10075.359140646671 9387.83119239117 9298.514948161632 8120.213868007667 10117.24653110307 11257.922549899402 8900.614471600624 0.9614888562739587 0.7949000749658987 1.1529841469205722 1.1319846705858714 1.0547396724512805 1.0447048322147416 0.9123205924621275 1.1366907940327469 1.2648477906576328 1.0 13.11968922349728 -5.263990045030103 24.996467617854474 1.0848306463934925 0.8781944623200346 0.42309883687797545 0.09762760006241641 205.7147732731191 2016021.6798362946 0.026277521793044878 0.05913952598783981 5.445151341652773e-06 5.263990045030103 -0.20663618407345785 YESLTDPSKLDSGK ddPTM_A459_Selumetinib_30min_R2 1 YESLTDPSKLDSGK 14 1 P07900;P07900-2;G3V2J8;P08238;Q58FF7;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 111.72 0.010829 21446000.0 184270.0 188850.0 192420.0 206630.0 208370.0 128360.0 132440.0 155100.0 108780.0 181080.0 False True 174029.01109125555 203334.18775154147 180039.90669105537 178486.63754336833 182192.69774856503 146040.42486393417 138598.7224248815 155551.31532181293 130539.03956715004 175851.74989765766 0.9896347985876575 1.1562818559944843 1.0238164066939062 1.01498357364794 1.0360584859382842 0.830474675110864 0.7881566291239257 0.8845593826182612 0.7423243706310643 1.0 17.424000165704335 -6.74829923028943 7.061801534770077 0.8377407413864781 1.0482982417159628 0.6233274678259964 0.07553660642175418 0.08879660151012003 20.967414626738968 0.02425306116659381 0.0232919094486344 1.7852571031375607e-07 6.74829923028943 0.21055750032948461 YESQEPLAGQES(ph)PLPLATR ddPTM_A459_Selumetinib_30min_R1 4 YESQEPLAGQESPLPLATR 19 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(0.996)PLPLAT(0.004)R;YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(1)PLPLATR 276.88 1.8879999999999996e-71 498424000.0 26258.0 29141.0 25434.0 26143.6 26971.699999999997 24977.6 28186.6 25241.8 14521.3 22556.2 True False 26869.76031082617 25729.158172716627 21980.2024989616 21578.111036151946 24532.114497240393 24726.348021846257 26060.462068838136 24572.305467078244 24641.58550621076 25451.507985993827 1.0557237050791968 1.0109089876668838 0.863611009259549 0.8478126737333818 0.963876659518195 0.971508172932361 1.0239260511864139 0.9654557789110407 0.9681778195528228 1.0 14.635463517165286 -6.692722005502015 3.6900949681807003 0.9866014185520904 0.9400771698766025 0.09105836834635705 0.059583180605924234 0.596988683320219 16.183878041965496 0.023194565312205942 0.022561338755634743 2.0289810668653972e-07 6.692722005502015 -0.04652424867548788 YESQEPLAGQES(ph)PLPLATR ddPTM_A459_Selumetinib_30min_R2 7 YESQEPLAGQESPLPLATR 19 0 Q9C0C2;Q9C0C2-2 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(0.996)PLPLAT(0.004)R;YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(1)PLPLATR;YESQEPLAGQES(0.993)PLPLAT(0.007)R 268.25 1.4628999999999995e-58 384801900.0 269679.7 274994.0 300720.2 333576.3 342290.8 235675.3 251490.3 265740.5 241281.5 290138.6 True False 254691.98188737422 296085.155554925 281372.18973139743 288142.63248878624 299289.1695854223 268137.43332763406 263185.09726857534 266513.760859292 289544.5419683888 281761.5447473854 0.9039274046986061 1.0508359322787697 0.9986181399724472 1.0226471208025278 1.0622072996290228 0.951646661250505 0.9340703235586502 0.9458840847079971 1.0276226382417846 1.0 18.10411519826316 -6.8043423776563365 24.999975872943402 0.966101573199794 1.010378509431912 0.11762815008216176 0.047456657368036684 255.6547478126638 148970.63249556482 0.01644169753997879 0.01450029211370768 1.5691252908890371e-07 6.8043423776563365 0.044276936232118036 YESS(ph)SYTDQFSR ddPTM_A459_Selumetinib_30min_R1 1 YESSSYTDQFSR 12 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 YES(0.002)S(0.934)S(0.06)YT(0.003)DQFSR 269.14 1.0962e-33 5506400.0 1644.2 2745.6 2169.2 2265.7 2025.5 1875.2 2153.7 1810.1 1161.4 1592.6 True False 1682.5066609437279 2424.1438756051894 1874.6345545626914 1870.0380274564122 1842.2938826310688 1856.337190545372 1991.2446750461816 1762.0902679665608 1970.8109747001436 1797.0257232376807 0.9362729977578589 1.3489756124568084 1.0431873791907573 1.0406295264862353 1.0251906017860606 1.0330053524224632 1.1080780031676891 0.9805592903766691 1.096707158509315 1.0 10.811395344885472 -5.448873430458384 24.999996765933133 1.0416554993761817 1.1559887758649872 0.14083059095105976 0.09938635617919268 205.33842798473503 69364.68336764359 0.023632675969487846 0.049195326331511476 3.557349778476232e-06 5.448873430458384 0.11433327648880542 YESS(ph)SYTDQFSR ddPTM_A459_Selumetinib_30min_R2 1 YESSSYTDQFSR 12 0 A0A087X0K9;G5E9E7;Q07157-2;G3V1L9;Q07157 A0A087X0K9;G3V1L9 TJP1 Tight junction protein ZO-1 1 YES(0.002)S(0.679)S(0.319)YTDQFSR 241.35 5.740899999999999e-63 0.0 21254.0 20225.0 15490.0 22743.0 18843.0 18279.0 19107.0 13885.0 17232.0 21374.0 True False 20072.7877665032 21776.19246637509 14493.390264236808 19645.364166136696 16475.773881442678 20796.766329758888 19995.513359802233 13925.403051214505 20678.881502308628 20756.87708367866 0.9670427630121022 1.0491073574597563 0.6982452228150017 0.9464508599698768 0.7937501298978035 1.0019217363922048 0.9633199290622049 0.6708814141489612 0.9962424221593834 1.0 14.341301783033412 YETPSDAIEVIS(ph)PASSPAPPQEK ddPTM_A459_Selumetinib_30min_R1 1 YETPSDAIEVISPASSPAPPQEK 23 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 YETPSDAIEVIS(0.941)PAS(0.056)S(0.003)PAPPQEK 87.48899999999998 0.0014665999999999998 0.0 1043.8 1615.9 1329.0 1249.8 1265.4 1267.4 1089.7 1520.9 583.48 1042.4 True False 1068.118509118758 1426.709676788471 1148.5290996744495 1031.5458916515977 1150.944793424515 1254.651106707128 1007.5030516774974 1480.5607914205516 990.1229443069047 1176.2021938358405 0.9081079041651853 1.2129799487413582 0.9764725025115425 0.8770140857223804 0.9785263107451314 1.0666967918291745 0.8565730084143272 1.2587638410978765 0.8417965461175578 1.0 10.199920371171642 YETPSDAIEVIS(ph)PASSPAPPQEK ddPTM_A459_Selumetinib_30min_R2 1 YETPSDAIEVISPASSPAPPQEK 23 0 O75376-2;O75376;A0A088AWL3;E7EVK1 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 YETPSDAIEVIS(0.999)PAS(0.001)SPAPPQEK 135.34 3.7288e-06 4307300.0 53493.0 49212.0 64899.0 57773.0 63242.0 46893.0 49584.0 53538.0 43915.0 53524.0 True False 50520.07320944557 52986.402158479665 60723.46899668848 49904.21773601612 55296.974569346574 53352.085097728785 51889.75424883206 53693.78671630697 52699.22708762091 51978.62304794691 0.9719394290772974 1.0193883379635345 1.1682392767633536 0.9600911838311438 1.0638406969407155 1.0264235943402145 0.9982902817753969 1.0329974818066636 1.013863469199815 1.0 15.665630795810303 -6.9994824018463175 24.46790741342796 1.013797501252609 1.039423992047894 0.044873679679404144 0.05407247884970651 50.73097865244654 2397940.6005490934 0.019175172514708037 0.016750632708938253 1.001192524285119e-07 6.9994824018463175 0.025626490795285006 YETSSTSAGDRYDS(ph)LLGR ddPTM_A459_Selumetinib_30min_R1 1 YETSSTSAGDRYDSLLGR 18 1 O14974-5;O14974-4;O14974-3;O14974-2;O14974;H0YIM2;H0YIS3 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 1 YETSS(0.001)T(0.007)S(0.032)AGDRY(0.145)DS(0.815)LLGR 77.668 0.0074654 14223000.0 1304.6 1299.2 1329.3 1463.1 1541.0 1284.1 1422.7 1304.4 933.73 927.84 True False 1334.994641690297 1147.0890600183068 1148.7883613222323 1207.5970507884874 1401.616822085648 1271.1831198695143 1315.3845935776592 1269.803074711663 1584.4716130590366 1046.937301926944 1.275142875541036 1.0956616579684648 1.0972847745589216 1.1534568961921985 1.3387781861491586 1.2141922133539744 1.2564120040012172 1.2128740397104225 1.5134350549385642 1.0 10.031959330648537 -6.1683786814913315 8.348114131441243 1.2644229732309007 1.146295435973983 0.1252943500071294 0.12817718211037626 0.5984159557272194 48.88019824435577 0.035951998460002466 0.046496055246515636 6.786116616050981e-07 6.1683786814913315 -0.11812753725691771 YEWDVAEAR ddPTM_A459_Selumetinib_30min_R1 2 YEWDVAEAR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 ; 185.72 0.007034 49901000.0 12249.8 13402.7 9424.8 9846.4 10872.2 9302.6 11784.4 11864.1 6700.2 11013.0 False True 12535.196506038477 11833.50565325382 8144.963926720662 8126.911079819407 9888.811429642814 9209.024290084993 10895.493220325136 11549.42552797197 11369.750036753832 12426.625825704243 1.0087369396855628 0.9522702155219348 0.6554445302338594 0.653991774903936 0.7957760673205427 0.7410719868169121 0.8767861343171701 0.9294096152860899 0.9149507031293819 1.0 13.601146997311572 -7.545155998837895 3.1658363559393674 0.9417797103129998 0.7946127782613631 0.2681759183971021 0.10834224785225507 0.39265962055837905 8.136760713673848 0.061968874300329484 0.034595939945044465 2.8499943639398208e-08 7.545155998837895 -0.14716693205163667 YEYDPDIS(ph)PPR ddPTM_A459_Selumetinib_30min_R1 4 YEYDPDISPPR 11 0 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 YEYDPDIS(1)PPR;YEYDPDIS(1)PPR;YEYDPDIS(1)PPR;YEYDPDIS(1)PPR 115.92 0.0060378 105259000.0 6308.64 7696.2 5608.610000000001 6126.5 6732.9 6008.29 6962.1 6510.289999999999 3330.16 6058.639999999999 True False 6455.619037523437 6795.125326133684 4846.991567889477 5056.621783648192 6123.910383790045 5947.852057690835 6436.943191781134 6337.615960797757 5651.038294736894 6836.325460151163 0.9443112495379489 0.9939733509971646 0.7090053854431766 0.7396695510070671 0.895789765932916 0.8700364095244989 0.9415793951446546 0.9270500647957187 0.8266192602556316 1.0 12.739005366370275 -6.875674248197617 2.3416293707233486 0.9161682794345882 0.8478700979418169 0.10819276298255809 0.08930564821130117 0.7920643069181095 8.855255658799548 0.038945436378938124 0.03345920718729969 1.3314527279337026e-07 6.875674248197617 -0.06829818149277134 YEYDPDIS(ph)PPR ddPTM_A459_Selumetinib_30min_R2 4 YEYDPDISPPR 11 0 Q9BRD0;H7C462 Q9BRD0 BUD13 BUD13 homolog 1 YEYDPDIS(1)PPR;YEYDPDIS(1)PPR;YEYDPDIS(1)PPR;YEYDPDIS(1)PPR 130.69 0.0023466 107422000.0 54998.0 43027.2 54290.6 51926.0 61993.0 48288.8 48115.4 52566.0 44776.1 51093.0 True False 51941.43133443793 46327.24788574603 50797.60190313588 44853.58922265374 54204.88511554825 54940.14387791793 50352.861438856344 52718.95835723024 53732.57114876517 49617.812334443435 1.0468303395629859 0.9336817909963923 1.0237775410318417 0.903981596776638 1.092448106139508 1.1072665499155807 1.0148142183185827 1.062500660083195 1.0829290656062516 1.0 15.598570507286322 -6.281145572521992 24.99808790856504 1.06322286326467 0.9773052161944433 0.4086031297337247 0.048781273419859175 760.2553301136112 964411.6663839355 0.014409505856233414 0.0163593730998857 5.234249587333824e-07 6.281145572521992 -0.08591764707022675 YFAES(ph)DEEEDDVDFAMFN ddPTM_A459_Selumetinib_30min_R1 3 YFAESDEEEDDVDFAMFN 18 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 1 YFAES(1)DEEEDDVDFAMFN;YFAES(1)DEEEDDVDFAMFN;YFAES(1)DEEEDDVDFAMFN 198.48 2.1244e-10 4932900.0 1916.1 2585.5299999999997 2468.849 2997.62 2117.6 2359.8999999999996 2170.9900000000002 2275.8900000000003 973.3399999999999 1796.19 True False 1960.741401918425 2282.8149456197125 2133.592866216828 2474.141939296416 1926.063453892645 2336.161548617762 2007.230476425923 2215.5260040674093 1651.6868900590994 2026.7484828722163 0.9674320313982675 1.1263434831265349 1.0527171399152582 1.2207444387920172 0.9503218925138234 1.1526647575465603 0.9903697934838794 1.0931430430517288 0.814944184745807 1.0 10.984951347799692 -8.245140475273361 24.72000101034936 0.9074720865314941 1.0718123816819427 0.3378776394130507 0.0905108059861387 625.9624324513519 949380.6112737639 0.056615208039797485 0.021249019942637986 5.686689615510529e-09 8.245140475273361 0.16434029515044857 YFDDEFTAQSIT(ph)ITPPDR ddPTM_A459_Selumetinib_30min_R1 1 YFDDEFTAQSITITPPDR 18 0 P31751-2;P31751;M0R0P9;M0R283 P31751-2 AKT2 RAC-beta serine/threonine-protein kinase 1 YFDDEFTAQSIT(0.5)IT(0.5)PPDR 214.34 7.7765e-12 12782000.0 523.41 810.58 365.89 387.75 332.55 494.7 468.81 499.66 206.82 474.75 True False 535.604434621431 715.6769167715813 316.2041476899055 320.0367414689605 302.47091121647117 489.7237671516615 433.4472842589034 486.4073936755822 350.95843446485566 535.6887869566051 0.9998425348126972 1.3359938348486593 0.5902758381155371 0.597430353708124 0.5646392431226559 0.9141945455567896 0.8091401104761522 0.9080036870642674 0.6551535947928774 1.0 9.065251287640367 -5.2623940202776724 24.99999251569436 0.7467828570474397 1.1679181934436798 0.5051681419645104 0.16337011380455962 63.39371902877557 1660198.7983072062 0.04294733253710591 0.09854731643191005 5.465198994019111e-06 5.2623940202776724 0.42113533639624 YFDDEFTAQSITIT(ph)PPDR ddPTM_A459_Selumetinib_30min_R1 2 YFDDEFTAQSITITPPDR 18 0 P31751-2;P31751;M0R0P9;M0R283 P31751-2 AKT2 RAC-beta serine/threonine-protein kinase 1 YFDDEFTAQSITIT(1)PPDR;YFDDEFTAQSIT(0.259)IT(0.741)PPDR 302.9 1.8523999999999996e-95 36051000.0 3340.8 4959.5 3051.8 2744.75 3268.1 3219.8 3630.7999999999997 4077.1 1831.1399999999999 3577.0 True False 3418.634139934802 4378.839434391004 2637.3823223374607 2265.4309378386324 2972.5009320299187 3187.4117353444926 3356.925832826148 3968.962063712757 3107.3108388259175 4036.142792930544 0.8470052511330046 1.084906966636737 0.6534412823443548 0.5612861224351675 0.736470705951327 0.7897172867440082 0.8317163205191674 0.9833552149504083 0.7698713842008983 1.0 11.978761500486094 -7.5200573484983275 4.337862641339578 0.9087457874576925 0.7768029212049222 0.16218178360220092 0.14027925881109468 0.43985475063142376 20.466629970130935 0.07255501044657511 0.0432387437538208 3.019552962717832e-08 7.5200573484983275 -0.1319428662527703 YFDDEFTAQSITIT(ph)PPDR ddPTM_A459_Selumetinib_30min_R2 4 YFDDEFTAQSITITPPDR 18 0 P31751-2;P31751;M0R0P9;M0R283 P31751-2 AKT2 RAC-beta serine/threonine-protein kinase 1 YFDDEFTAQSIT(0.002)IT(0.998)PPDR;YFDDEFTAQSIT(0.002)IT(0.998)PPDR;YFDDEFTAQSIT(0.03)IT(0.97)PPDR;YFDDEFTAQSIT(0.001)IT(0.999)PPDR 174.19 5.1253e-08 15342200.0 42746.4 31452.8 42406.799999999996 50436.8 50251.7 41633.3 56401.0 54926.1 52007.8 40564.2 True False 40370.726215397226 33865.1286233079 39678.39265703279 43567.22083166704 43938.63219010207 47367.909165531564 59023.7582564613 55085.925857494665 62410.81321934577 39393.00614755116 1.0248196358557633 0.8596736308080185 1.0072445984044143 1.1059633445713908 1.1153917024134876 1.2024446417749755 1.4983308975045173 1.3983681684805627 1.5843120219253817 1.0 15.26565189522392 -6.6705368911153125 1.2344312165314317 1.402421749211672 0.9693676085003616 0.5257232201594648 0.15576601744402654 0.3149401391221444 1.0118356034196416 0.07136839187000053 0.07007808335837827 2.1353206936718544e-07 6.6705368911153125 -0.4330541407113103 YFDNKDDDSDTETS(ph)NDLPK ddPTM_A459_Selumetinib_30min_R2 1 YFDNKDDDSDTETSNDLPK 19 1 C9J3R1;C9IZP0;J3KR59;J3KR68;Q9UID6 C9J3R1 ZNF639 Zinc finger protein 639 1 YFDNKDDDS(0.144)DT(0.246)ET(0.246)S(0.365)NDLPK 58.46100000000001 0.025493 9544900.0 45634.0 40430.0 41851.0 40658.0 40566.0 30519.0 35479.0 33227.0 28243.0 40189.0 True False 43097.84496737591 43530.85099706032 39158.3522239235 35120.3102610379 35469.7364153587 34722.71522610165 37128.8438003048 33323.685068974046 33892.38917535414 39028.639146437825 1.1042620473050617 1.1153566188595487 1.0033235357502215 0.8998599753699933 0.9088130457809224 0.8896727117699368 0.9513230441111493 0.853826466865564 0.8683979230786868 1.0 15.252245539202734 -5.4994311427504075 2.47995814621811 0.9044069269802625 1.1123734018413398 0.7991007479285466 0.03992496220204775 0.1133978192046104 1.3730145638753555 0.010969524798673691 0.026098599710989236 3.166422458891959e-06 5.4994311427504075 0.20796647486107733 YFDS(ph)GDYNMAK ddPTM_A459_Selumetinib_30min_R1 7 YFDSGDYNMAK 11 0 A6NMQ3;Q5T5H1;O43768-2;O43768;O43768-9;O43768-3;O43768-4;O43768-6;O43768-5;O43768-7;H3BQ52;H3BTD3;P56211-2;H3BMD8;P56211 A6NMQ3;H3BTD3;P56211 ENSA;ARPP19 Alpha-endosulfine;cAMP-regulated phosphoprotein 19 1 YFDS(1)GDYNMAK;Y(0.006)FDS(0.994)GDYNMAK;YFDS(1)GDYNMAK;YFDS(1)GDYNMAK;YFDS(1)GDYNMAK;YFDS(1)GDYNMAK;Y(0.105)FDS(0.895)GDYNMAK 178.15 6.071600000000001e-05 1789463800.0 33705.600000000006 37469.1 37556.1 36118.7 34251.3 32895.5 35705.5 33670.700000000004 19935.9 28551.0 True False 34490.87490031926 33082.200353087996 32456.187900890603 29811.247076969572 31153.27596255816 32564.601136724268 33012.20538833703 32777.643658152396 33829.76623947355 32215.79896029076 1.0706198825871978 1.0268936801432478 1.0074618338938652 0.9253610973210679 0.967018573742583 1.0108270534238013 1.024720989506668 1.0174400361311593 1.0500986264898218 1.0 14.97548075396908 -6.997916381074661 24.9404439875035 1.023554791649185 0.9964813717460091 0.07969313716154414 0.03710296668923502 176.52079796337094 2112881.72682879 0.014538971808394054 0.012745883522846382 1.004809237314726e-07 6.997916381074661 -0.0270734199031758 YFDS(ph)GDYNMAK ddPTM_A459_Selumetinib_30min_R2 5 YFDSGDYNMAK 11 0 A6NMQ3;Q5T5H1;O43768-2;O43768;O43768-9;O43768-3;O43768-4;O43768-6;O43768-5;O43768-7;H3BQ52;H3BTD3;P56211-2;H3BMD8;P56211 A6NMQ3;H3BTD3;P56211 ENSA;ARPP19 Alpha-endosulfine;cAMP-regulated phosphoprotein 19 1 Y(0.246)FDS(0.754)GDYNMAK;YFDS(1)GDYNMAK;Y(0.103)FDS(0.897)GDYNMAK;Y(0.073)FDS(0.927)GDYNMAK;YFDS(1)GDYNMAK 156.52 0.00054829 633492800.0 354716.0 278101.0 330045.0 396256.0 351803.0 331995.0 264192.0 313093.0 226261.0 309737.0 True False 335002.3047606548 299430.45246434456 308810.26402582496 342285.24922027235 307606.3619812757 377724.2976994527 276477.4514865165 314004.0487946639 271519.52226055355 300794.088016627 1.1137263600145522 0.9954665480253486 1.0266500450924914 1.1379387523113547 1.0226476325035756 1.2557570535713896 0.9191585290440737 1.0439169561647326 0.902675727607867 1.0 18.198416686156776 YFEADPPGQVAAS(ph)PDPTT ddPTM_A459_Selumetinib_30min_R1 4 YFEADPPGQVAASPDPTT 18 0 O43598;H0Y8X4 O43598 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 1 YFEADPPGQVAAS(0.724)PDPT(0.138)T(0.138);YFEADPPGQVAAS(0.998)PDPT(0.001)T(0.001);YFEADPPGQVAAS(0.996)PDPT(0.002)T(0.002);YFEADPPGQVAAS(0.908)PDPT(0.046)T(0.046) 146.67 0.00023882 24914900.0 7854.9 9081.3 9034.8 9571.1 9974.8 7791.900000000001 9598.3 8923.9 4811.8 7579.4 True False 8037.903887025234 8018.057174218171 7807.923784604004 7899.687056798375 9072.581101193975 7713.520560479141 8874.292503364339 8687.209183087558 8165.2731600328525 8552.289819607988 0.9398540106295964 0.9375333791699888 0.9129629548688396 0.9236926277552734 1.060836488538205 0.9019245983449035 1.0376510490813922 1.0157758175091585 0.9547470130528299 1.0 13.062095028532754 -6.191527455058635 24.99992544470531 0.99340821405699 0.9280445292501218 0.37963805278654295 0.041698449313612225 175.85210167254942 62882.6403802861 0.011796320456982914 0.015228982933750858 6.43387390294323e-07 6.191527455058635 -0.06536368480686816 YFEADPPGQVAAS(ph)PDPTT ddPTM_A459_Selumetinib_30min_R2 4 YFEADPPGQVAASPDPTT 18 0 O43598;H0Y8X4 O43598 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 1 YFEADPPGQVAAS(0.997)PDPT(0.002)T(0.002);YFEADPPGQVAAS(0.999)PDPT(0.001)T(0.001);YFEADPPGQVAAS(0.996)PDPT(0.002)T(0.002);YFEADPPGQVAAS(0.916)PDPT(0.042)T(0.042) 192.23 2.4918e-10 18846000.0 272780.0 247543.0 296195.0 312903.0 320860.0 219691.0 230415.0 247413.0 216022.0 285117.0 True False 257619.97962485842 266528.7521238022 277138.1361727329 270285.07161221764 280550.6982752058 249951.441093663 241129.75405866088 248132.93086857285 259232.4361589897 276884.9313870685 0.9304225344958235 0.9625975338875016 1.0009144765820084 0.9761638896642424 1.0132393152266304 0.9027267747707293 0.870866293989744 0.8961590275987174 0.9362460963850661 1.0 18.07892701602649 -6.776759879314882 24.992708729176684 0.9115637283620249 0.9772049543056592 0.33008233296514866 0.03829562417247776 239.66604232633858 390970.7327681452 0.01333328132202966 0.011801125891822159 1.6720148129577272e-07 6.776759879314882 0.06564122594363431 YFEGEFTGLPPALT(ph)PPAPHSLLTAR ddPTM_A459_Selumetinib_30min_R1 2 YFEGEFTGLPPALTPPAPHSLLTAR 25 0 Q6P5Z2 Q6P5Z2 PKN3 Serine/threonine-protein kinase N3 1 YFEGEFTGLPPALT(0.732)PPAPHS(0.06)LLT(0.208)AR;YFEGEFTGLPPALT(0.995)PPAPHS(0.003)LLT(0.002)AR 83.85 0.00016084 43954000.0 1831.94 2169.96 2671.7 2577.5 2234.0 2036.17 2200.21 2040.31 1233.6100000000001 1893.47 True False 1874.6206376652794 1915.9000744129644 2308.897814597612 2127.3880106673014 2031.9350944447342 2015.6879784944383 2034.246388300767 1986.1943509390926 2093.346070690412 2136.5153184596584 0.8774197036962064 0.8967406214500027 1.0806839504723207 0.99572794647738 0.9510510300996473 0.9434465370216341 0.952132835521805 0.9296419893544497 0.9797945526548485 1.0 11.061043945601803 -5.029279427991946 24.995644590194797 0.9748953877137155 0.8822498614861142 0.45222358612579505 0.040529466761708814 565.5578239650961 482813.95083776134 0.01099693869325495 0.02920326231724435 9.348040214170928e-06 5.029279427991946 -0.09264552622760136 YFGTDAVPDGS(ph)DEEEVAYTG ddPTM_A459_Selumetinib_30min_R1 1 YFGTDAVPDGSDEEEVAYTG 20 0 Q9NWZ5;Q9NWZ5-4 Q9NWZ5 UCKL1 Uridine-cytidine kinase-like 1 1 YFGTDAVPDGS(0.999)DEEEVAYT(0.001)G 67.846 0.014015 2222200.0 2525.3 2770.6 2387.8 2437.6 2677.1 2307.0 2561.7 2256.6 1287.6 2314.1 True False 2584.134576621577 2446.216863983004 2063.549875246539 2011.9189194190549 2434.956777680393 2283.7936745884044 2368.468906563498 2196.747637530158 2184.9631574168293 2611.137276242821 0.989658644198095 0.9368396239599007 0.7902877776750948 0.7705144182668234 0.9325272936948243 0.8746356215612558 0.907064108851259 0.8412991754654392 0.8367860155406246 1.0 11.35046259162293 YFPSS(ph)LSPVTPSESLPR ddPTM_A459_Selumetinib_30min_R2 1 YFPSSLSPVTPSESLPR 17 0 K7EKZ6;K7EQ21;Q9P0U4;Q9P0U4-2 K7EKZ6 CXXC1 CXXC-type zinc finger protein 1 1 YFPS(0.174)S(0.749)LS(0.071)PVT(0.003)PS(0.001)ES(0.001)LPR 67.749 0.038147 2860600.0 4438.5 3732.6 4680.8 5318.0 6085.2 5957.2 6131.6 4943.2 5886.2 5841.2 True False 4191.825938723276 4018.8784177993416 4379.642424069701 4593.679225938307 5320.72277362177 6777.75022592263 6416.731549534899 4957.583893609186 7063.604474169517 5672.549378739769 0.7389668487389253 0.7084783488816783 0.772076562345006 0.8098085920864833 0.9379773393535162 1.1948331822945535 1.131190073652644 0.8739604651463745 1.245225735829344 1.0 12.469781547070573 -6.352830115275199 2.3355448878317446 1.0831661604636265 0.7442703817701026 0.7108882724422367 0.09940317406045193 0.16559636394113 1.770617689073593 0.033375728815872224 0.04001491741636236 4.437822060588609e-07 6.352830115275199 -0.33889577869352383 YFPSSCLDLNSPT(ph)SPTPTR ddPTM_A459_Selumetinib_30min_R1 2 YFPSSCLDLNSPTSPTPTR 19 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 YFPSSCLDLNS(0.088)PT(0.877)S(0.035)PTPTR;YFPSSCLDLNS(0.08)PT(0.791)S(0.126)PT(0.002)PTR 249.41 2.893e-37 15190500.0 2128.88 2327.05 2337.0 2716.8 2777.1 1937.4099999999999 2512.3 2294.9 971.82 1825.07 True False 2178.478761920619 2054.5979041838045 2019.6482362221134 2242.3618806521536 2525.9117953368263 1917.921414427534 2322.7951883356673 2234.031797114225 1649.1075610755067 2059.335512187238 1.0578551911664158 0.9976994482077369 0.9807281155837632 1.0888764202733152 1.2265664241637022 0.9313302291332282 1.1279343140490043 1.0848313856062437 0.8007959612778083 1.0 11.007963181332538 -8.243466662240133 24.83409615480745 0.9003979696292083 1.0613533244047124 0.3420423556909462 0.08963746659531845 724.6140965030495 1001251.4058313005 0.06003010120323496 0.022582774111713402 5.708648958084792e-09 8.243466662240133 0.16095535477550416 YFPSSCLDLNSPTS(ph)PTPTR ddPTM_A459_Selumetinib_30min_R1 2 YFPSSCLDLNSPTSPTPTR 19 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 YFPSSCLDLNS(0.001)PT(0.009)S(0.989)PTPTR;YFPSSCLDLNS(0.002)PT(0.115)S(0.88)PT(0.003)PTR 197.6 2.8144e-15 29090000.0 3752.8999999999996 4092.3 4955.2 5563.0 4920.200000000001 4099.3 4297.5 4027.2000000000003 2234.69 3422.8999999999996 True False 3840.3352681277897 3613.171613541343 4282.311056965263 4591.52648044314 4475.1687787318615 4058.0647638665996 3973.3361150629007 3920.3855738107995 3792.105714700073 3862.2625568694343 0.9943226830339008 0.93550647071234 1.1087571064656723 1.1888178011814952 1.1586909778498382 1.05069624452354 1.0287586761795648 1.015048955394808 0.9818352996109546 1.0 11.915230526790662 -7.398057778466627 2.2329829380690307 0.9995450428279913 1.0780347509671702 0.19210735214159314 0.06928784343498125 0.6318325663316172 6.156628070766385 0.04264094451646382 0.024930942828793427 3.998915447164735e-08 7.398057778466627 0.07848970813917888 YFPSSCLDLNSPTS(ph)PTPTR ddPTM_A459_Selumetinib_30min_R2 3 YFPSSCLDLNSPTSPTPTR 19 0 A0A096LNR9;A0A1B0GUM4;A0A669KBC2;O76039;O76039-1 A0A096LNR9 CDKL5 Cyclin-dependent kinase-like 5 1 YFPSSCLDLNS(0.001)PT(0.241)S(0.747)PT(0.009)PT(0.002)R;YFPSSCLDLNSPT(0.035)S(0.921)PT(0.038)PT(0.005)R;YFPSSCLDLNSPT(0.025)S(0.887)PT(0.062)PT(0.025)R 216.34 5.003100000000001e-19 25900000.0 32581.9 34983.399999999994 41010.9 39893.4 44154.6 33413.9 31834.199999999997 32850.8 24732.4 34361.9 True False 30771.128433679838 37666.514290639614 38372.30334329175 34459.85010004649 38607.504400867656 38016.3614238159 33314.553378270575 32946.39038925729 29679.57108099456 33369.782664061844 0.9221255272609051 1.1287611510639297 1.1499116949484198 1.0326663031329422 1.1569600194743452 1.1392451010703846 0.9983449312107523 0.9873121057135164 0.8894145754493774 1.0 15.026254669890442 -7.473265348445006 3.4685387709963194 0.9567136335322933 1.0932198758005833 0.40504776955829314 0.07162235871560259 0.23767273648362752 5.76058013305716 0.03406264663373994 0.020583681934573276 3.36306027853456e-08 7.473265348445006 0.13650624226829 YFPSSLS(ph)PVTPSESLPR ddPTM_A459_Selumetinib_30min_R2 1 YFPSSLSPVTPSESLPR 17 0 K7EKZ6;K7EQ21;Q9P0U4;Q9P0U4-2 K7EKZ6 CXXC1 CXXC-type zinc finger protein 1 1 YFPS(0.012)S(0.062)LS(0.792)PVT(0.129)PS(0.005)ESLPR 137.17 0.00051215 3394700.0 16489.0 12343.0 16051.0 16076.0 16436.0 11505.0 14847.0 18601.0 13385.0 12979.0 True False 15572.607390696887 13289.668410999644 15018.296135007422 13886.421067353183 14371.162740295696 13089.709318008423 15537.414918772374 18655.125830438676 16062.374008147695 12604.262546508156 1.2355032540171158 1.054378894597159 1.1915251748836382 1.1017241997390979 1.1401827506581919 1.0385144921973046 1.232711145252747 1.4800648400970378 1.2743604751868298 1.0 13.621624090636102 -7.514366024291904 24.964140957534667 1.2976051857050197 1.1268551132516382 0.15689072637438695 0.12339099655215825 497.9488334162918 1460282.077266104 0.05186341428269683 0.031858167390243594 3.059383891719709e-08 7.514366024291904 -0.17075007245338147 YFPSSLS(ph)PVTPSESLPRPR ddPTM_A459_Selumetinib_30min_R1 2 YFPSSLSPVTPSESLPRPR 19 1 K7EKZ6;K7EQ21;Q9P0U4;Q9P0U4-2 K7EKZ6 CXXC1 CXXC-type zinc finger protein 1 1 YFPS(0.012)S(0.043)LS(0.945)PVTPSESLPRPR;YFPS(0.001)S(0.005)LS(0.994)PVTPSESLPRPR 165.03 5.2921e-08 81918000.0 3570.5 3751.7 3701.2 4604.5 4440.2 3195.8999999999996 3604.5 3603.0 1701.12 2939.6 True False 3653.6857030164097 3312.449219881986 3198.5973692363227 3800.4105121697717 4038.58469398098 3163.7521476450274 3332.609663000402 3507.436735806596 2886.6763951109947 3316.9262941287766 1.101527552627179 0.998650234026992 0.9643257297872716 1.1457627258395222 1.2175684160150306 0.9538204551741534 1.0047282838028044 1.0574358381176687 0.8702865662769298 1.0 11.695631238821084 -8.240337455155311 23.51237594907095 0.9351432971812756 1.05387713503938 0.2500370938041985 0.08332480441259223 484.9247696896894 540320.1143182687 0.05936136409337864 0.02236943461277766 5.749929831200393e-09 8.240337455155311 0.11873383785810443 YFPSSLS(ph)PVTPSESLPRPR ddPTM_A459_Selumetinib_30min_R2 2 YFPSSLSPVTPSESLPRPR 19 1 K7EKZ6;K7EQ21;Q9P0U4;Q9P0U4-2 K7EKZ6 CXXC1 CXXC-type zinc finger protein 1 1 YFPS(0.002)S(0.013)LS(0.985)PVTPSESLPRPR;YFPSS(0.001)LS(0.832)PVT(0.053)PS(0.078)ES(0.036)LPRPR 152.68 0.00020419 17279000.0 27403.3 22620.4 31403.2 28618.9 26673.5 28467.3 18697.1 20125.6 19853.1 25815.4 True False 25880.334290101506 24355.311943950117 29382.75230121896 24720.95644964381 23322.53646588449 32388.412174579884 19566.552197600784 20184.162164027573 23824.274741961664 25070.042325535625 1.032321124713082 0.9714906591578625 1.172026433768344 0.9860755769232888 0.9302950574650136 1.2919169323296267 0.7804754353234918 0.8051108132142467 0.9503085169383596 1.0 14.613676811412917 -7.299433661715413 24.999037274973887 0.8677329252638378 1.0551031365035664 0.3636665377236581 0.11552166548055567 598.8122522134614 393997.3656841442 0.047112925405555416 0.03176424156673304 5.0184122920193665e-08 7.299433661715413 0.18737021123972852 YFQINQDEEEEEDED ddPTM_A459_Selumetinib_30min_R1 6 YFQINQDEEEEEDED 15 0 K7ERI7;P35268 K7ERI7 RPL22 60S ribosomal protein L22 0 ;;;;; 257.72 4.305e-35 299533200.0 15818.230000000001 19973.25 18682.48 20585.82 19353.6 16248.45 16825.94 14460.259999999998 9077.93 12894.68 False True 16186.763982082402 17634.772604687987 16145.501831516873 16990.892980700337 17603.070297155602 16085.005345412214 15556.745799157989 14076.72693125581 15404.584184225656 14549.837782819586 1.1125047731594433 1.2120253756719601 1.1096688549051346 1.1677719871738461 1.2098464986284085 1.1055109744526053 1.0692040716445208 0.9674834277449866 1.0587461120986073 1.0 13.828715448062642 -7.27369230181381 2.1726136230013413 1.0113500134326658 1.1616488458114171 0.7279935373250831 0.04029192059321494 0.1573464372343499 1.4528626382197452 0.01894153333448896 0.012150266639553806 5.324853922209753e-08 7.27369230181381 0.1502988323787513 YFQINQDEEEEEDED ddPTM_A459_Selumetinib_30min_R2 3 YFQINQDEEEEEDED 15 0 K7ERI7;P35268 K7ERI7 RPL22 60S ribosomal protein L22 0 ;; 135.99 0.0056444 47076180.0 54431.5 50494.2 58862.4 53335.0 61637.2 42205.399999999994 46104.2 44117.0 38369.5 52887.0 False True 51406.41513655873 54366.94277555683 55075.2572685354 46070.68099199314 53893.78389244066 48018.81074752481 48248.13665373917 44245.37316603747 46044.47213340475 51360.01489307166 1.0009034312700975 1.0585460866540908 1.0723372526896389 0.8970145567112746 1.049333494249255 0.9349454210147129 0.9394104879873726 0.8614750844242076 0.8965042597683521 1.0 15.648358000353854 -6.5413146138380895 0.8650664841427449 0.9105349309749863 1.036187322713012 0.3500304723865937 0.05764344417289727 0.605451413635073 0.9974869589902607 0.03291228914031491 0.03918275283509036 2.875314709839779e-07 6.5413146138380895 0.12565239173802578 YFQISQDEDES(ph)ESED ddPTM_A459_Selumetinib_30min_R1 3 YFQISQDEDESESED 15 0 C9JYQ9;H0Y8C2;Q6P5R6 C9JYQ9 RPL22L1 60S ribosomal protein L22-like 1 1 YFQISQDEDES(0.986)ES(0.014)ED;YFQISQDEDES(0.997)ES(0.003)ED;YFQISQDEDES(0.921)ES(0.079)ED 153.81 0.00020042 10413900.0 5500.960000000001 6001.139999999999 5788.139999999999 6330.0 6162.49 5347.16 5611.0 4617.29 2876.98 4568.66 True False 5629.12166499514 5298.523738945705 5002.142379977176 5224.5843288163 5605.093867575978 5293.3724252328275 5187.757752557984 4494.824470128345 4882.024933694524 5155.092013516931 1.0919536741992728 1.0278233104380463 0.9703303775880793 1.0134803249131454 1.0872926909702325 1.0268240433639821 1.006336596700001 0.871919348547547 0.9470296399935424 1.0 12.331782463227315 -7.5852188262669245 6.9746402329526935 0.9323784851218059 1.0328011020388037 0.4890023646668863 0.04388973131475058 0.1795942083022556 16.237220873203285 0.021127819272506922 0.012121720191476016 2.5988497609165317e-08 7.5852188262669245 0.10042261691699783 YFQISQDEDES(ph)ESED ddPTM_A459_Selumetinib_30min_R2 5 YFQISQDEDESESED 15 0 C9JYQ9;H0Y8C2;Q6P5R6 C9JYQ9 RPL22L1 60S ribosomal protein L22-like 1 1 YFQISQDEDES(0.5)ES(0.5)ED;YFQISQDEDES(0.798)ES(0.202)ED;YFQISQDEDES(0.965)ES(0.035)ED;YFQISQDEDES(0.5)ES(0.5)ED;YFQISQDEDES(0.907)ES(0.093)ED 110.54 0.0034751999999999995 14115100.0 128497.0 133792.0 149072.0 145778.0 155989.0 118615.0 111381.0 122344.0 104096.0 138864.0 True False 121355.65115424688 144053.4161909151 139480.86981732157 125922.78491892347 136392.26726064636 134953.13957023647 116560.4371972646 122700.00078486059 124918.10868525543 134854.63550799817 0.8998997379444871 1.0682125656879726 1.0343053413914645 0.9337668256235436 1.011402142365043 1.0007304462458204 0.8643413462072014 0.9098686175869966 0.9263167574083621 1.0 17.041045588219887 -7.236126298785515 24.60421252834641 0.9176207292913765 0.9951199205239303 0.25569586715189574 0.05455864851423987 744.1156038023337 723277.9697686761 0.02033744961959526 0.015746401121763322 5.805955478277658e-08 7.236126298785515 0.07749919123255378 YFQISQDEDESES(ph)ED ddPTM_A459_Selumetinib_30min_R1 2 YFQISQDEDESESED 15 0 C9JYQ9;H0Y8C2;Q6P5R6 C9JYQ9 RPL22L1 60S ribosomal protein L22-like 1 1 YFQISQDEDES(0.004)ES(0.996)ED;YFQISQDEDES(0.002)ES(0.998)ED 137.62 0.00040089 13973500.0 13036.1 14689.0 12730.5 14582.0 13328.8 11580.4 13346.3 11190.099999999999 7749.3 10701.8 True False 13339.815766165015 12969.205051269171 11001.76802363098 12035.527438040961 12123.212393390764 11463.911690161927 12339.57784583223 10893.302197432518 13149.996113521462 12075.48027435955 1.1047027085531405 1.074011530523329 0.9110832673870177 0.9966914080921964 1.0039528132999038 0.9493545125905927 1.0218705646046602 0.9021009475343844 1.0889832797328554 1.0 13.559792949617336 -5.090048947684527 6.601511949803226 0.9821573334392985 1.0974610585897764 0.404000683894976 0.05158065656794813 0.18890322092177317 11.424314856864937 0.012076979688936201 0.03305670177039557 8.12738910280657e-06 5.090048947684527 0.11530372515047793 YFQS(ph)PSR ddPTM_A459_Selumetinib_30min_R1 1 YFQSPSR 7 0 Q16629;Q16629-4;H7BZZ6 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 1 YFQS(0.999)PS(0.001)R 137.05 0.005298 9605800.0 2458.9 2360.5 2073.6 2334.1 2354.3 2001.8 2663.9 2474.8 1064.2 2189.0 True False 2516.187585813486 2084.131562633322 1792.0165094694805 1926.4932514834322 2141.3539806854237 1981.6637094889766 2462.959878281806 2409.160264716671 1805.8696739072607 2469.9794726656314 1.0187078935915148 0.84378497299174 0.725518786411417 0.7799632639879139 0.8669521363974936 0.8022996674342161 0.99715803533531 0.9753766342505982 0.7311274016210121 1.0 11.270283336671815 -7.24355966983048 24.668187664624117 0.9238635799645942 0.833086332003909 0.1474096725034597 0.10100843614994025 1356.2892041343425 1871240.17809038 0.03931151644850827 0.03038666827823655 5.70742653676333e-08 7.24355966983048 -0.0907772479606852 YFQSPS(ph)R ddPTM_A459_Selumetinib_30min_R2 1 YFQSPSR 7 0 Q16629;Q16629-4;H7BZZ6 Q16629 SRSF7 Serine/arginine-rich splicing factor 7 1 YFQS(0.227)PS(0.773)R 79.48899999999998 0.046662 17039000.0 39126.0 33639.0 39118.0 38163.0 47251.0 32355.0 35758.0 35213.0 37782.0 32109.0 True False 36951.533553787754 36219.00313356696 36601.190468458066 32965.133565152995 41314.90695070044 36811.60756055305 37420.81785313277 35315.464000174026 45339.45571728323 31181.929740799027 1.1850303640906377 1.1615382189184185 1.173794911755201 1.0571870900607152 1.324963121081093 1.1805429576216395 1.2000802440450202 1.1325618489213194 1.4540298209305573 1.0 14.928422593708698 -6.254065086797923 24.899091368975707 1.2194859516512988 1.1477132169081257 0.08171592718133991 0.11585258934191639 1473.8208922212668 4976310.162544764 0.032643418671404204 0.04128063750473627 5.571022509360284e-07 6.254065086797923 -0.07177273474317314 YGDGGSSFQSTTGHCVHMR ddPTM_A459_Selumetinib_30min_R1 1 YGDGGSSFQSTTGHCVHMR 19 0 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 0 110.6 0.00035061 5169800.0 1797.9 2130.3 2267.4 2704.9 2837.2 2224.0 2414.2 2137.0 1097.2 1740.9 False True 1839.7875718955888 1880.8834856503984 1959.4995339366794 2232.5399922614884 2580.575760948344 2201.628579230433 2232.094950316429 2080.31981804571 1861.8682636826215 1964.361472802009 0.9365830054034173 0.9575037546259061 0.997524926581667 1.1365219808943532 1.313696993490385 1.1207858684430319 1.1362954228238444 1.0590310626884243 0.9478236513297174 1.0 10.939844716878017 -5.631823980977878 4.098580685695944 1.1152175639624933 0.9531507055358324 0.3205025059944643 0.09236582102965285 0.2558673530940185 7.77830067123882 0.027563894778985524 0.04998660235034659 2.334404001659562e-06 5.631823980977878 -0.1620668584266609 YGDGGSTFQSTTGHCVHMR ddPTM_A459_Selumetinib_30min_R1 1 YGDGGSTFQSTTGHCVHMR 19 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;D6RIT2;H0YBG7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 114.06 0.00027263 14024000.0 2870.5 3138.1 3461.6 4162.7 5138.7 3516.4 3611.2 3752.9 1366.4 2366.5 False True 2937.3770649793028 2770.689793136888 2991.533733207733 3435.762588556652 4673.905492311169 3481.0282086357465 3338.8042766062013 3653.360900862771 2318.681002092541 2670.2633266620446 1.100032732970633 1.0376091996141747 1.1203141290740384 1.2866755702522858 1.7503537743424622 1.3036273141597599 1.2503651768231654 1.3681650286639127 0.8683342121883544 1.0 11.382766304229232 -8.263685413128416 24.992292607934615 0.9341670709554966 1.2800124675582976 0.3458930943431723 0.18862566575418482 252.57308836143304 2810356.646340678 0.17239505749042341 0.05285899026008929 5.448972133251092e-09 8.263685413128416 0.345845396602801 YGEHEAS(ph)PDNGQNEFSDIIK ddPTM_A459_Selumetinib_30min_R1 1 YGEHEASPDNGQNEFSDIIK 20 0 P46939;Q5SYY2 P46939 UTRN Utrophin 1 Y(0.008)GEHEAS(0.899)PDNGQNEFS(0.093)DIIK 57.238 0.025875 3760000.0 1896.9 2242.6 1971.0 2018.0 1929.6 1881.1 1973.1 2272.8 1252.7 1909.0 True False 1941.0940792751223 1980.0353494435444 1703.3490259280215 1665.594182551548 1755.0680206985496 1862.1778419021439 1824.2674784480753 2212.517960905143 2125.740406411976 2154.0387452346686 0.9011416733191829 0.919219932243063 0.790769910567441 0.7732424434037246 0.8147801540623385 0.8645052676149851 0.8469056011568321 1.0271486368570883 0.9868626602537692 1.0 11.072828484894806 -7.755681902357202 24.923683083326686 1.0052542502602675 0.8420850796168875 0.7402095048891193 0.04350483689464714 71.25899325970228 308478.9473089931 0.0237618769916198 0.013236905993639827 1.755165596735935e-08 7.755681902357202 -0.16316917064338 YGEHEAS(ph)PDNGQNEFSDIIK ddPTM_A459_Selumetinib_30min_R2 1 YGEHEASPDNGQNEFSDIIK 20 0 P46939;Q5SYY2 P46939 UTRN Utrophin 1 YGEHEAS(1)PDNGQNEFSDIIK 78.236 0.0032878 3075100.0 41018.0 32426.0 39314.0 39363.0 40913.0 32930.0 36653.0 38411.0 29573.0 36270.0 True False 38738.383768063824 34912.969933976696 36784.580041846726 34001.69149503752 35773.14317313932 37465.80859122273 38357.43712654167 38522.769650716626 35488.42633865906 35222.79085922266 1.099810174693203 0.9912039643171875 1.044340301961482 0.9653321234803457 1.0156248923066968 1.0636808633638628 1.088994829508186 1.093688737064681 1.0075415795556373 1.0 15.104221604426774 -6.760696038608243 24.993155441117345 1.0590251033935452 1.0194339271497497 0.072007788724189 0.04367500229317319 37.83722918221019 1272183.9944697167 0.01453711418206061 0.01372572499144486 1.7350179066739157e-07 6.760696038608243 -0.03959117624379549 YGGDEIPFS(ph)PYR ddPTM_A459_Selumetinib_30min_R1 2 YGGDEIPFSPYR 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 YGGDEIPFS(1)PYR;YGGDEIPFS(1)PYR 169.58 0.00034175 68453000.0 5015.5 5754.0 6454.4 7210.9 6080.9 5475.5 5322.7 4944.5 3141.8 4393.2 True False 5132.3513915358635 5080.319005037973 5577.92793148139 5951.651680357263 5530.883668670092 5420.421441356222 4921.204453669648 4813.3557980004725 5331.40513200698 4957.110013391803 1.0353515208802389 1.0248550044911888 1.1252378737636297 1.2006293312592764 1.11574761377662 1.0934640197035708 0.9927567555238527 0.9710003984170267 1.0755067201663886 1.0 12.275283561629209 -7.221279020032672 6.393069128899692 1.0073908474991689 1.1027677730628425 0.4128453340355174 0.052120688946150226 0.22583019964159978 26.62611215463055 0.022495546433850773 0.017118726624381266 6.007876270194874e-08 7.221279020032672 0.09537692556367361 YGGDEIPFS(ph)PYR ddPTM_A459_Selumetinib_30min_R2 3 YGGDEIPFSPYR 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 1 YGGDEIPFS(1)PYR;YGGDEIPFS(1)PYR;YGGDEIPFS(1)PYR 174.94 0.00012235 34759600.0 88416.0 87968.0 93887.0 109948.0 124651.0 81307.0 81538.0 82308.0 75801.0 100521.0 True False 83502.19267729117 94714.86273829814 87846.41263643636 94972.89272912084 108991.2269859211 92506.30121854074 85329.67856448192 82547.50265317713 90963.31805689963 97618.69754507665 0.8553913827700169 0.9702532928649491 0.8998933077945666 0.9728965363962772 1.1164994998585496 0.947628922992184 0.8741120370416731 0.8456115962319595 0.9318226973361962 1.0 16.574869882584117 -10.086887863328826 11.132936477727842 1.000008667859819 0.9373300886188022 0.06388385055784018 0.07423695366745624 0.0 0.0 0.07804986448846522 0.018929872667711005 8.18676146488719e-11 10.086887863328826 -0.06267857924101683 YGGDSDHPS(ph)DGETSVQPMMTK ddPTM_A459_Selumetinib_30min_R2 2 YGGDSDHPSDGETSVQPMMTK 21 0 Q8WYQ5-3;Q8WYQ5;Q8WYQ5-2 Q8WYQ5-3 DGCR8 Microprocessor complex subunit DGCR8 1 Y(0.005)GGDS(0.005)DHPS(0.989)DGETSVQPMMTK;Y(0.003)GGDS(0.011)DHPS(0.934)DGET(0.024)S(0.028)VQPMMTK 76.90899999999998 0.0017977999999999996 10610900.0 58780.0 60799.0 74066.0 90728.0 95171.0 59418.0 57402.0 72309.0 71989.0 76715.0 True False 55513.242914983435 65462.08780040244 69300.67419696355 78370.68988547004 83214.768140465 67602.29015709908 60071.30673990517 72519.40721860073 86388.81154072033 74500.03862049265 0.745143813921641 0.8786852867804534 0.9302099096885714 1.0519550236033395 1.116976174527448 0.907412820300254 0.8063258469691775 0.9734143573806536 1.159580761840806 1.0 16.184953553011212 -4.937932271591943 1.6510724122738192 0.9920085377381533 0.704273997532976 0.4083926531116474 0.09565512587994374 0.8177588950991423 2.777021510207317 0.02953429446167547 0.3446165616945782 1.153633153371318e-05 4.937932271591943 -0.2877345402051773 YGGELVPHFPAR ddPTM_A459_Selumetinib_30min_R2 1 YGGELVPHFPAR 12 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-8 FLNB Filamin-B 0 85.288 0.044207 2851300.0 37481.0 27646.0 36354.0 42165.0 40004.0 27401.0 30402.0 27347.0 25475.0 31943.0 False True 35397.956068331 29766.359304099165 34015.0232192424 36422.054261317935 34978.33987970246 31175.239028487544 31815.75324042013 27426.575242460436 30570.71183097218 31020.72259211884 1.141106754145187 0.9595636986116384 1.0965258181279212 1.1741201112630226 1.1275797904394753 1.0049810714727825 1.025629017697456 0.8841372137936098 0.9854932211907601 1.0 14.920944672239528 -7.119215307003984 2.0489333445672564 0.9581676672315061 1.0942403287567593 0.4611424829565687 0.06392858963617779 0.3098312168540395 2.5610181253731703 0.031040478312421883 0.022151996510537588 7.599494289552307e-08 7.119215307003984 0.1360726615252531 YGGPNHIVGS(ph)PFK ddPTM_A459_Selumetinib_30min_R1 1 YGGPNHIVGSPFK 13 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 YGGPNHIVGS(1)PFK 77.74600000000002 0.028108 16374000.0 3992.9 4564.5 5450.6 5110.0 4671.0 4631.8 4258.7 4092.3 2669.8 3704.0 True False 4085.9268011690824 4030.0862180215186 4710.438458002676 4217.634426579982 4248.5088747320315 4585.208297337914 3937.462830300959 3983.7589103361984 4530.455605523024 4179.444480015301 0.977624375848659 0.9642636090255622 1.1270489368925487 1.0091375652308079 1.0165247786032265 1.0970855861976008 0.9421019585565935 0.9531790479297415 1.0839851150520459 1.0 12.029095480751105 -9.40747211443463 10.697893968873123 1.0000032806093841 1.0182998353664432 0.008571354520395813 0.060874013969124605 0.0 0.0 0.05918123117843531 0.014353556894281527 3.913162523012918e-10 9.40747211443463 0.018296554757059047 YGGPNHIVGS(ph)PFK ddPTM_A459_Selumetinib_30min_R2 2 YGGPNHIVGSPFK 13 0 O75369-8;O75369-2;O75369-9;O75369;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-8 FLNB Filamin-B 1 YGGPNHIVGS(1)PFK;YGGPNHIVGS(1)PFK 106.35 0.0046222 40531000.0 374590.0 393450.0 383520.0 407580.0 392830.0 312880.0 356490.0 342490.0 261722.0 382020.0 True False 353771.7874025801 423626.34985885146 358844.7407450036 352066.90088528366 343479.1834552418 355976.3799581467 373067.4913715335 343486.5891977282 314073.71312367765 370990.0899928383 0.9535882411560088 1.141880501085701 0.9672623350988456 0.9489927369544563 0.9258446322969771 0.959530697882034 1.0055996142073103 0.9258645944002413 0.8465824872296202 1.0 18.501021124061488 -5.4977516745751585 22.581910062832694 0.945013011270089 1.0494437365305092 0.32030039846189295 0.059225328152458526 232.07655783755925 208566.97543427962 0.014977214777397063 0.030887062420958792 3.1786910962429355e-06 5.4977516745751585 0.10443072526042019 YGGSVGSQPPPVAPEPGPVPS(ph)SPSQEPPTKR ddPTM_A459_Selumetinib_30min_R1 2 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 E9PS08;A0A087WTZ5;E9PJ81;E9PRQ7;Q04323;Q04323-2 E9PS08 UBXN1 UBX domain-containing protein 1 1 YGGSVGSQPPPVAPEPGPVPS(0.478)S(0.478)PS(0.043)QEPPT(0.001)KR;YGGSVGSQPPPVAPEPGPVPS(0.493)S(0.493)PS(0.014)QEPPTKR 168.91 3.8557999999999997e-28 138296000.0 4628.7 5985.8 6448.799999999999 6950.6 6358.6 5970.0 6276.2 5551.7 3112.6099999999997 4672.4 True False 4736.539704117641 5284.979753277078 5573.088380722794 5736.808188921106 5783.465752702006 5909.947220326299 5802.781181002389 5404.450881536903 5281.871833960229 5272.1480530301 0.8984079461492693 1.0024338656877445 1.0570811602150916 1.0881348799800774 1.0969847004539324 1.1209752004080449 1.1006483738003743 1.0250946724515377 1.0018443679563478 1.0 12.364175169494619 -4.812912613511618 1.8320513175011757 1.068685221036203 0.8502068658032669 0.6056485198318988 0.040122432361740595 0.5499632169426517 2.0291347358733707 0.011815537203388708 0.20562614980725777 1.538464170960574e-05 4.812912613511618 -0.21847835523293613 YGGSVGSQPPPVAPEPGPVPSS(ph)PSQEPPTKR ddPTM_A459_Selumetinib_30min_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 E9PS08;A0A087WTZ5;E9PJ81;E9PRQ7;Q04323;Q04323-2 E9PS08 UBXN1 UBX domain-containing protein 1 1 YGGSVGSQPPPVAPEPGPVPS(0.397)S(0.475)PS(0.115)QEPPT(0.013)KR 48.694 0.010247 10342000.0 829.98 1017.8 1113.2 1301.8 1031.8 850.03 1056.4 1134.6 682.04 977.57 True False 849.3169191400524 898.6355028376171 962.0335543699003 1074.4650678124897 938.4738721790861 841.4794699654877 976.7148974874804 1104.5067222997957 1157.3720657693177 1103.0506318381645 0.7699709284647426 0.8146820072439446 0.8721572034882316 0.9740849937431805 0.8507985445919001 0.762865679668045 0.8854669670601126 1.001320057683304 1.0492465462266496 1.0 10.107283299186426 -7.733203908853519 3.5473394333839456 1.0242530184757714 0.8460460242251887 0.658182998324089 0.05680179219866935 0.1557966842545389 4.081093995305227 0.03474862482365375 0.017199352846676206 1.8484005588249956e-08 7.733203908853519 -0.17820699425058273 YGGSVGSQPPPVAPEPGPVPSS(ph)PSQEPPTKR ddPTM_A459_Selumetinib_30min_R2 4 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 E9PS08;A0A087WTZ5;E9PJ81;E9PRQ7;Q04323;Q04323-2 E9PS08 UBXN1 UBX domain-containing protein 1 1 YGGSVGSQPPPVAPEPGPVPS(0.356)S(0.594)PS(0.048)QEPPT(0.001)KR;YGGSVGSQPPPVAPEPGPVPS(0.37)S(0.576)PS(0.053)QEPPT(0.001)KR;YGGSVGSQPPPVAPEPGPVPS(0.369)S(0.578)PS(0.043)QEPPT(0.01)KR;YGGSVGSQPPPVAPEPGPVPS(0.348)S(0.608)PS(0.042)QEPPT(0.002)KR 144.43 1.6208e-19 152768000.0 452365.0 480849.0 510744.0 586591.0 557436.0 401790.0 369146.0 412182.0 361834.0 506725.0 True False 427224.36426057306 517728.57212677307 477883.2870960215 506696.29387408315 487405.90613893163 457132.92541352566 386312.0204489222 413381.3813795962 434210.9104866732 492094.5326203365 0.8681753930198358 1.0520916974426413 0.9711209034397476 1.029672675239845 0.9904721020645392 0.928953473592472 0.7850361969921982 0.8400446539781625 0.8823729623138853 1.0 18.90857596203808 -6.98912023673595 4.689824788585564 0.8621870919257788 0.9868441746078674 0.33755105857158774 0.06812437700205541 0.1814710310465302 10.518939061659822 0.024252988838728583 0.02031719944355488 1.0253680083673368e-07 6.98912023673595 0.12465708268208864 YGLQDS(ph)DEEEEEHPSK ddPTM_A459_Selumetinib_30min_R1 4 YGLQDSDEEEEEHPSK 16 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 YGLQDS(1)DEEEEEHPSK;YGLQDS(1)DEEEEEHPSK;YGLQDS(1)DEEEEEHPSK;YGLQDS(1)DEEEEEHPSK 246.49 3.335e-29 71230600.0 11065.5 13309.0 11322.400000000001 12898.4 12925.9 11574.0 12537.6 10561.199999999999 4478.77 8346.08 True False 11323.304620285126 11750.776092813758 9784.880269491337 10645.936572954848 11756.75462725299 11457.576068351185 11591.878737920326 10281.082668387617 7600.145573581674 9417.3806657036 1.2023836587091097 1.2477754175965259 1.039023547718115 1.1304562224744112 1.2484102580740915 1.2166414924775855 1.2309026415525344 1.0917136126640248 0.8070339135020879 1.0 13.201110131540524 -8.063146811434024 4.74525656332233 0.9083215299798187 1.184786596860548 0.6974646588869686 0.07400653889800439 0.12230032167936807 5.409939194677091 0.053250921036649926 0.01961659447134539 8.646755694033063e-09 8.063146811434024 0.27646506688072925 YGLQDS(ph)DEEEEEHPSK ddPTM_A459_Selumetinib_30min_R2 3 YGLQDSDEEEEEHPSK 16 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 YGLQDS(0.995)DEEEEEHPS(0.005)K;YGLQDS(1)DEEEEEHPSK;YGLQDS(1)DEEEEEHPSK 223.93 3.0839e-11 131173000.0 300918.0 199441.0 307135.0 379122.0 381900.0 288776.0 269959.0 302938.0 249093.0 318759.0 True False 284194.18223019707 214737.48339610992 287374.26848330384 327484.9295780709 333922.3077706823 328552.2727524727 282512.6284136099 303819.49942591466 298918.5602399358 309555.5994346556 0.9180715281817665 0.6936960073999212 0.9283445978949767 1.057919579475092 1.078715127041888 1.0613675648332994 0.9126393737653767 0.981469887738368 0.9656377102719307 1.0 18.23983903032117 -5.495722246908728 6.605781785432061 1.007778765218852 0.8058218607733428 0.5784184644165582 0.06870554976701197 0.12409677554166954 19.54943599217381 0.018512092371675542 0.0370466634501082 3.193579656390442e-06 5.495722246908728 -0.20195690444550907 YGLQDSDEEEEEHPS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 YGLQDSDEEEEEHPSK 16 0 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 YGLQDS(0.001)DEEEEEHPS(0.999)K 227.63 4.1503e-15 25646000.0 49669.0 46807.0 60122.0 65620.0 74472.0 55462.0 59116.0 60586.0 47081.0 56194.0 True False 46908.59582076073 50396.94639177348 56253.81597588419 56682.442799186036 65116.16157187273 63101.38706609161 61865.011136131754 60762.29522944777 56498.515553052006 54571.53321045376 0.8595799505918021 0.9235024824649678 1.0308271119842418 1.0386815151517113 1.19322580365763 1.1563059227737413 1.1336498627874514 1.113443065547004 1.0353111270516606 1.0 15.735860956960666 -5.313001928903619 1.3645878158058715 1.1122087976415824 0.847536174336275 0.6859976655762872 0.055553564872903305 0.3271172442790158 0.9780246791354767 0.017554577391631996 0.09116546415717325 4.864050453358163e-06 5.313001928903619 -0.2646726233053074 YGMGTS(ph)VER ddPTM_A459_Selumetinib_30min_R1 4 YGMGTSVER 9 0 P08559-3;P08559;P08559-2;P08559-4 P08559-3 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1 YGMGT(0.002)S(0.998)VER;YGMGT(0.028)S(0.972)VER;YGMGT(0.145)S(0.855)VER;YGMGT(0.004)S(0.996)VER 125.71 0.0049782 230649000.0 22474.9 34045.4 30131.7 34644.5 28885.2 30731.199999999997 30140.7 27147.9 14264.100000000002 21020.600000000002 True False 22998.521441457367 30059.348740722944 26039.980641580616 28594.48843280826 26272.538760096264 30422.072029697072 27867.16273258323 26427.849503192843 24205.13589135553 23718.79876798319 0.9696326389219133 1.2673217153517295 1.0978625391742298 1.2055622509604709 1.1076673408756366 1.2826143653936763 1.174897725857842 1.1142153429315511 1.0205042897884367 1.0 14.533743326391342 -8.173924482722251 2.586988619761528 1.0019018173384753 1.1640531895155992 0.3192351720556419 0.08490956190546572 0.3170131482246842 3.802885240502106 0.0701918083059287 0.02132229123891059 6.700011024016006e-09 8.173924482722251 0.16215137217712394 YGMGTS(ph)VER ddPTM_A459_Selumetinib_30min_R2 3 YGMGTSVER 9 0 P08559-3;P08559;P08559-2;P08559-4 P08559-3 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1 YGMGT(0.027)S(0.973)VER;YGMGT(0.034)S(0.966)VER;YGMGT(0.021)S(0.979)VER 93.096 0.025021 122949000.0 1156690.0 849182.0 957905.0 1135450.0 896693.0 674481.0 1001629.0 810738.0 806091.0 714963.0 True False 1092405.8003969414 914311.5288495092 896274.435188104 980799.7512394983 784042.4088028703 767384.6354210904 1048206.7331902104 813097.1133550988 967331.724064382 694320.160493037 1.5733459325467716 1.3168442757016536 1.2908662115639264 1.4126044540360632 1.129223164492475 1.1052316770928419 1.509687882958603 1.1710694282270564 1.3932070233672598 1.0 19.40524153701905 -9.804948192235083 0.03541285242534082 5.125764557481025e-26 2.309806964005496 0.3214307273899669 0.14577991225202752 408.3983867213281 3.7823757384892245 142.031818180928 104.98360625394497 1.566937981791693e-10 9.804948192235083 2.309806964005496 YGPADVEDTTGSGATDS(ph)KDDDDIDLFGSDDEEESEEAKR ddPTM_A459_Selumetinib_30min_R1 1 YGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKR 39 2 P24534;C9JZW3 P24534 EEF1B2 Elongation factor 1-beta 1 Y(0.001)GPADVEDT(0.166)T(0.166)GS(0.139)GAT(0.128)DS(0.364)KDDDDIDLFGS(0.036)DDEEESEEAKR 52.056 0.00093058 3473700.0 535.13 713.4 588.41 707.27 436.01 453.89 543.89 556.66 284.58 424.95 True False 547.5974878182808 629.8747963493375 508.5071539047729 583.7585716021966 396.5729724838178 449.32427869914625 502.86393941164863 541.8955685134886 482.9114750991621 479.4964718635267 1.142026104363364 1.3136171657350821 1.0605023889508474 1.21744080688115 0.827061293991522 0.9370752551168551 1.0487333461647925 1.1301346314550604 1.007122061237204 1.0 8.905376389702761 -6.2282393250739245 24.987407098710236 0.9983161105474295 1.183919957382468 0.49980580191062995 0.09381315827490651 597.0640837614019 449369.1514079956 0.029125611987243956 0.037598692357761865 5.91235734270832e-07 6.2282393250739245 0.1856038468350384 YGPADVEDTTGSGATDSKDDDDIDLFGS(ph)DDEEESEEAKR ddPTM_A459_Selumetinib_30min_R1 1 YGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKR 39 2 P24534;C9JZW3 P24534 EEF1B2 Elongation factor 1-beta 1 YGPADVEDT(0.123)T(0.123)GS(0.092)GAT(0.022)DS(0.061)KDDDDIDLFGS(0.577)DDEEESEEAKR 67.899 3.673e-06 18591000.0 914.42 809.66 1004.4 1137.4 518.05 820.56 712.45 592.65 475.84 866.33 True False 935.724206848414 714.8646307992782 868.0079967742794 938.7744416422851 471.192468969156 812.3059114088688 658.7093229032141 576.9309968014928 807.4657260214535 977.5318942688059 0.9572313827656088 0.7312954543892372 0.8879587478048986 0.9603517257556988 0.4820226037960716 0.8309763764961079 0.6738494434454528 0.5901914814074045 0.8260249417492798 1.0 9.932999964269168 -6.205239394207409 24.999930907973717 0.7152089637954934 0.873554703499322 0.19503521217452768 0.14611124281465723 444.12833361784396 197564.99663774905 0.04077743117143494 0.0526434212675693 6.233911116584525e-07 6.205239394207409 0.1583457397038286 YGPADVEDTTGSGATDSKDDDDIDLFGS(ph)DDEEESEEAKR ddPTM_A459_Selumetinib_30min_R2 3 YGPADVEDTTGSGATDSKDDDDIDLFGSDDEEESEEAKR 39 2 P24534;C9JZW3 P24534 EEF1B2 Elongation factor 1-beta 1 YGPADVEDT(0.008)T(0.008)GS(0.049)GAT(0.049)DS(0.159)KDDDDIDLFGS(0.725)DDEEES(0.002)EEAKR;Y(0.001)GPADVEDT(0.037)T(0.093)GS(0.123)GAT(0.019)DS(0.047)KDDDDIDLFGS(0.677)DDEEES(0.003)EEAKR;YGPADVEDT(0.009)T(0.009)GS(0.008)GAT(0.008)DS(0.067)KDDDDIDLFGS(0.899)DDEEES(0.001)EEAKR 61.099 3.1587e-05 239150200.0 127029.0 113099.8 116441.0 111290.0 96093.6 86562.6 98689.6 91247.7 71554.3 111542.0 True False 119969.23671737713 121774.19098682457 108949.31283137521 96132.11001404194 84021.46288031626 98485.81241295396 103278.86194973243 91513.21570013004 85867.1593941875 108321.49263907928 1.1075293904701575 1.124192328041203 1.00579589679758 0.8874703225734561 0.7756675137432858 0.9091991811920722 0.9534475516678061 0.8448297144967027 0.792706574680352 1.0 16.724959998522927 -5.561115164590801 2.574972005888659 0.8730511155475488 1.1154645941178036 0.6873580247989339 0.06413572298390345 0.1542593080973987 2.0479256874037866 0.01854858480663409 0.04047264081510596 2.7471655733857677e-06 5.561115164590801 0.24241347857025486 YGPS(ph)LMPGGNK ddPTM_A459_Selumetinib_30min_R1 2 YGPSLMPGGNK 11 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 Y(0.096)GPS(0.904)LMPGGNK;Y(0.134)GPS(0.866)LMPGGNK 106.67 0.010988 25159000.0 2949.34 4663.7 4294.7 4820.8 3843.6 3816.4 3687.8 4415.299999999999 1893.37 3518.2 True False 3018.053883583367 4117.671835904689 3711.5033290984666 3978.9377776236365 3495.947058642696 3778.0104810139496 3409.626276935185 4298.191901084334 3212.910603726546 3969.7952401700422 0.760254295497138 1.0372504340370745 0.9349357094144453 1.002303024942214 0.8806366190546772 0.9516890047084953 0.8588922275973955 1.082723828572132 0.8093391244000091 1.0 11.954848880541766 -14.52287874507837 0.0068514253838721844 1.9937996783228693 3.196721287164458e-10 0.036915574745430835 0.09629569408253885 135955.99237652545 70.52965828729549 11380.612538567519 9246.749907589454 3.000000001395148e-15 14.52287874507837 -1.9937996780031972 YGPS(ph)LMPGGNK ddPTM_A459_Selumetinib_30min_R2 1 YGPSLMPGGNK 11 0 P52209-2;P52209;K7EM49;K7EMN2;K7EPF6 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 Y(0.389)GPS(0.611)LMPGGNK 87.831 0.035617 0.0 67452.0 64466.0 67043.0 58456.0 61554.0 56905.0 58704.0 59972.0 49136.0 57548.0 True False 63703.287871750035 69410.33490913906 62729.52637089915 50494.19195777539 53821.03622025806 64743.147217841746 61433.85231976923 60146.50859110094 58964.5729745495 55886.43971233927 1.1398702118017525 1.241988848572399 1.1224462802386923 0.9035142016145766 0.9630428507753879 1.1584768604171252 1.09926222954949 1.0762272368876824 1.0550783567186264 1.0 15.770210649505279 -5.526258616931965 24.976502590370607 1.0419144116313563 1.1887515610620882 0.43708320157577674 0.07112101682924 93.42052205223347 690354.151209291 0.020940075066521478 0.036508607187538865 2.976743288143863e-06 5.526258616931965 0.1468371494307319 YGQFSGLNPGGRPIT(ph)PPR ddPTM_A459_Selumetinib_30min_R2 2 YGQFSGLNPGGRPITPPR 18 1 P62136-3;P62136;P62136-2 P62136-3 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 YGQFSGLNPGGRPIT(1)PPR;YGQFSGLNPGGRPIT(1)PPR 102.15 0.0032821999999999994 13205800.0 64722.0 59125.0 63720.0 74189.0 71390.0 60908.0 55050.0 63842.0 56662.0 56199.0 True False 61125.01034269413 63659.69738316083 59620.32457309037 64084.33021683667 62421.34996530235 69297.52413222578 57609.93407950554 64027.76965038795 67995.98326855918 54576.38884746221 1.1199900109465823 1.1664329342325293 1.09241974106652 1.1742134569575242 1.1437427664876536 1.2697345059950427 1.055583472928594 1.1731771009866885 1.245886448416438 1.0 15.735989318606128 -4.743541640490261 22.85250787542308 1.1522638183139118 1.1199897175404754 0.006275097819992026 0.07737555035269442 2273.932144062999 2902974.7947973246 0.01807204272827572 0.471802915883308 1.804921671551349e-05 4.743541640490261 -0.0322741007734364 YGQSS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 YGQSSPR 7 0 A0A0A0MRJ3;Q8NEY1-7;Q8NEY1-4;Q8NEY1-2;Q8NEY1-3;Q8NEY1;Q8NEY1-6 A0A0A0MRJ3 NAV1 Neuron navigator 1 1 YGQS(0.084)S(0.916)PR 80.165 0.0454 2692600.0 28690.0 18367.0 21068.0 25465.0 23525.0 21533.0 46038.0 91598.0 29320.0 55796.0 True False 27095.524655169724 19775.6898407867 19712.507817104022 21996.623070424776 20569.579183831615 24498.975292887935 48178.85822256638 91864.53501513468 35184.819269248444 54185.024504582 0.500055594749772 0.36496596654882807 0.36379992437646846 0.4059539194000862 0.3796174196081098 0.45213553960497427 0.889154497263211 1.6953860564807242 0.6493458218566117 1.0 15.725606558466747 -7.361808023783922 3.605666383443504 1.151925087412582 0.4027096976129678 0.6311960405333075 0.24487999909162758 0.13908964096259221 3.346988667133594 0.10276255978694236 0.06656239535419498 4.347023382127692e-08 7.361808023783922 -0.7492153897996141 YGRPPDSHHSR ddPTM_A459_Selumetinib_30min_R2 1 YGRPPDSHHSR 11 1 Q01130-2;Q01130;J3QL05;J3KP15 Q01130-2 SRSF2 Serine/arginine-rich splicing factor 2 0 104.43 0.034668 263610.0 0.0 0.0 471.7 0.0 474.35 0.0 0.0 0.0 645.35 843.27 False True 0.0 0.0 441.35133554812785 0.0 414.7579122571956 0.0 0.0 0.0 774.4380325855898 818.9226040214146 0.0 0.0 0.5389414498767293 0.0 0.5064677787870047 0.0 0.0 0.0 0.9456791506091319 1.0 9.677583299674302 -8.268594524012471 24.588948978374418 0.9728398405252416 0.1393878931203585 0.7333273957586377 0.2030861899457272 244.17761827352928 839112.0962659698 0.18106431601089057 0.05074248384465862 5.3877256898671395e-09 8.268594524012471 -0.8334519474048832 YGS(ph)FEEAEASYPILNR ddPTM_A459_Selumetinib_30min_R1 3 YGSFEEAEASYPILNR 16 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 YGS(1)FEEAEASYPILNR;YGS(1)FEEAEASYPILNR;YGS(1)FEEAEASYPILNR 143.93 0.00039053 10713200.0 2333.9300000000003 2327.6499999999996 2179.35 2533.7 2552.1800000000003 2017.03 2147.27 2242.3900000000003 1314.07 2235.7599999999998 True False 2388.3060279627757 2055.127655904872 1883.4062403126513 2091.236858439473 2321.335769623975 1996.7405095167096 1985.2996951230048 2182.914532890743 2229.8808141245204 2522.7415741466016 0.9467105360447778 0.8146405787125005 0.7465712142749992 0.8289540553304201 0.9201639174671474 0.7914962554942518 0.7869611836062107 0.8652945490975167 0.8839117081894721 1.0 11.300776711034747 -8.674621557712186 1.6012629282221644 0.9993410895755868 0.8318575027027245 0.4242361250764235 0.05740276604197784 0.5950608414197357 3.069009807342676 0.05636894416456845 0.016248722403439875 2.1153315274754125e-09 8.674621557712186 -0.16748358687286224 YGS(ph)FEEAEASYPILNR ddPTM_A459_Selumetinib_30min_R2 2 YGSFEEAEASYPILNR 16 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 YGS(1)FEEAEASYPILNR;YGS(1)FEEAEASYPILNR 111.81 0.0025567 5793100.0 21986.0 19713.1 16261.4 19030.0 16615.5 12297.4 14556.099999999999 14670.3 13441.400000000001 15303.599999999999 True False 20764.10613693138 21225.031382393005 15215.15922807363 16438.081171418944 14528.112345545342 13991.255225317413 15232.987492364957 14712.988144201101 16130.055584095357 14861.745304472013 1.397151257240514 1.4281654642544728 1.0237801090222742 1.1060666721608128 0.9775508897446736 0.9414274662012501 1.0249797167349675 0.9899905995410815 1.085340601230846 1.0 13.859315929763257 -5.263396642168763 24.59027197829794 1.0174079697826537 1.4126583978602887 0.9204374922578802 0.046336226971148614 31.61979455294876 397266.3120221521 0.012556183368141592 0.028451939942409576 5.452596467017251e-06 5.263396642168763 0.395250428077635 YGS(ph)PPQR ddPTM_A459_Selumetinib_30min_R2 2 YGSPPQR 7 0 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 Y(0.117)GS(0.883)PPQR;Y(0.001)GS(0.999)PPQR 82.75 0.040577 45768000.0 92214.0 68798.0 91048.0 87185.0 84907.0 82029.0 70126.0 109462.0 86317.0 78730.0 True False 87089.11504188989 74074.5853795636 85190.07080556711 75310.25259748627 74240.2235817891 93327.75016487727 73386.99795203278 109780.51629759044 103582.81189848966 76456.86033489386 1.1390621411921045 0.9688415801421155 1.1142240268881083 0.9850032066137 0.9710080070853614 1.2206589409516175 0.9598484378064365 1.4358491287339472 1.3547876730064454 1.0 16.222358337343252 -7.754570809969147 24.999975444882278 1.2964888112262027 1.0513721018187674 0.340448909742352 0.13306946320572616 143.97542961575118 524042.0217057332 0.06054180749832892 0.03395042888690738 1.7596617346398573e-08 7.754570809969147 -0.24511670940743535 YGS(ph)PPQRDPNWNGER ddPTM_A459_Selumetinib_30min_R1 1 YGSPPQRDPNWNGER 15 1 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 YGS(1)PPQRDPNWNGER 128.85 0.0044371 35771000.0 2063.4 2314.7 2473.8 2808.3 2087.6 1870.4 2180.8 1742.3 1253.3 1643.9 True False 2111.4732053225207 2043.6938479251648 2137.8715476107245 2317.8831233198766 1898.7769485957147 1851.5854741873216 2016.3005002278467 1696.0885442119982 2126.758562589709 1854.9105779419976 1.1383153616306272 1.1017748630193376 1.15254695996325 1.2495929188627204 1.0236487791785556 0.9982074048235979 1.0870068477720956 0.9143775254620572 1.1465558436511392 1.0 10.857133923330688 -6.293032046102683 24.165937724481324 1.0254490136986107 1.15578657777016 0.48618855425085694 0.06649717430518545 374.3177402034061 286322.8600080679 0.019821673059250252 0.022478272497674114 5.092932894900913e-07 6.293032046102683 0.13033756407154917 YGVYEDENYEVGS(ph)DDEEIPFK ddPTM_A459_Selumetinib_30min_R1 2 YGVYEDENYEVGSDDEEIPFK 21 0 O15541 O15541 RNF113A RING finger protein 113A 1 YGVYEDENYEVGS(1)DDEEIPFK;YGVYEDENY(0.001)EVGS(0.999)DDEEIPFK 134.68 2.5967e-05 32571000.0 11133.6 12439.2 13413.9 14258.3 12331.0 11222.5 12748.8 11241.599999999999 6964.2 10129.1 True False 11392.991217785606 10982.81268117281 11592.366057278483 11768.355566439408 11215.66322721487 11109.611839214725 11787.14775188223 10943.43625013694 11817.738754956725 11429.268650789147 0.9968259182532178 0.9609374857431924 1.0142701524894224 1.0296682951473757 0.981310665616428 0.9720317352456012 1.0313125110650343 0.957492258210357 1.033989060545948 1.0 13.48044546922285 -5.26909435563028 24.951435542087495 1.0011442675117364 0.978881701643655 0.11489012599602799 0.02601253763288987 1063.9973439097805 3468113.0558200036 0.006562571360978462 0.014037154708329417 5.38152849720979e-06 5.26909435563028 -0.022262565868081396 YGYEIPVDMLCK ddPTM_A459_Selumetinib_30min_R1 1 YGYEIPVDMLCK 12 0 G3V5Z7;P60900;G3V3I1;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 172.59 0.032282 11456000.0 1928.0 2021.6 2047.6 1646.3 1712.8 1208.0 1573.9 1405.4 1154.6 1636.9 False True 1972.9186487650559 1784.9101321836572 1769.5471666617022 1358.8046098784 1557.8775424193998 1195.8486167762426 1455.17945584584 1368.1242266174268 1959.2718713524928 1847.0120597562238 1.0681677135478205 0.9663770860376715 0.9580593463451745 0.7356771725993714 0.8434582406706185 0.6474503566230507 0.7878559580373831 0.7407229527228952 1.0607791438086687 1.0 10.850977570849086 -5.612314943001154 5.124148899882203 0.8115336715772303 1.0050700096531442 0.28712591469466575 0.1194546810566315 0.23033325798337742 10.01882740686008 0.03203907225008026 0.056888622960397664 2.44165926058299e-06 5.612314943001154 0.19353633807591386 YHAEEVEER ddPTM_A459_Selumetinib_30min_R1 1 YHAEEVEER 9 0 Q6NZY4;Q6NZY4-2;F5H6J5;F5GX80 Q6NZY4 ZCCHC8 Zinc finger CCHC domain-containing protein 8 0 170.5 0.0008828 2506600.0 969.54 1100.0 1527.0 1440.7 1386.6 1020.6 1281.4 1093.6 617.31 927.37 False True 992.1283956035643 971.2114886238736 1319.641787210598 1189.1087902884124 1261.1822748241127 1010.3336906306565 1184.7429663389407 1064.5941754865644 1047.529983461465 1046.4069728487561 0.9481286166342882 0.9281393509638328 1.2611171575223574 1.1363731522651865 1.2052502587885559 0.9655265272937803 1.1322009476997046 1.017380620647333 1.001073206354552 1.0 10.031228344200938 -7.897315425046557 6.936844198375399 1.003469508014622 1.0854958579872571 0.10216426887668273 0.1039301576513427 0.5430978671744625 31.742205236154227 0.06082029692045173 0.028943667501647705 1.2667315134315824e-08 7.897315425046557 0.08202634997263503 YHEEFEK ddPTM_A459_Selumetinib_30min_R1 6 YHEEFEK 7 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 ;;;;; 155.51 0.0021418 89705300.0 39723.2 48044.6 50442.99999999999 53824.799999999996 44465.0 43105.3 44485.799999999996 39079.1 24370.500000000004 33927.49999999999 False True 40648.673272107924 42419.5158966714 43593.11766356531 44425.309096630575 40443.14860093334 42671.69981848096 41130.20029027694 38042.595321193294 41354.95854910442 38282.42510683562 1.0618102996001106 1.1080676257653561 1.1387240369937126 1.1604622479545608 1.056441656662757 1.1146550851832426 1.0743885784532712 0.9937352509676953 1.0802596343803772 1.0 15.224394603803532 -7.542191964187551 4.851421377007109 1.0278158701114097 1.1076361679688076 0.5028111675426734 0.03640568350639406 0.16090775455114834 10.095373686758444 0.017417671723338735 0.010181420345612023 2.8695119375705187e-08 7.542191964187551 0.07982029785739786 YHEEFEK ddPTM_A459_Selumetinib_30min_R2 4 YHEEFEK 7 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 ;;; 152.47 0.002892 82462000.0 830040.0 756130.0 792290.0 806820.0 873780.0 612850.0 661330.0 684910.0 563085.0 763420.0 False True 783909.6997133873 814122.7396588459 741314.923980128 696929.724157867 764007.9447076884 697264.5246016043 692083.155400535 686902.9747070458 675717.7339094375 741378.0809966312 1.0573683250246366 1.0981208650846872 0.9999148113248529 0.9400463029888712 1.0305240528296116 0.9404978950339007 0.9335090598715445 0.9265218278150944 0.9114347338149966 1.0 19.499849936633375 -5.4057754037511385 0.8103924479119965 0.9419129935221785 1.1106765878099947 0.6022751720137377 0.037851332280025636 0.7985822612507519 0.7240917056241223 0.016117105396959062 0.10359850829226473 3.928480450179904e-06 5.4057754037511385 0.16876359428781618 YHGHS(ph)MSDPGVSYR ddPTM_A459_Selumetinib_30min_R1 4 YHGHSMSDPGVSYR 14 0 P08559-3;P08559;P08559-2;P08559-4;Q5JPU3;P29803 P08559-3 PDHA1;PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial 1 YHGHS(1)MSDPGVSYR;Y(0.001)HGHS(0.974)MS(0.025)DPGVSYR;Y(0.048)HGHS(0.914)MS(0.037)DPGVSYR;YHGHS(0.942)MS(0.058)DPGVSYR 203.05 2.6357e-05 534009000.0 6867.77 12361.3 10464.7 11609.199999999999 10254.8 10126.400000000001 10613.599999999999 8649.3 2993.79 6839.2 True False 7027.775678645849 10914.033249387538 9043.651218482482 9581.871151673644 9327.255150631985 10024.537610035553 9813.007606941614 8419.892467114061 5080.242972229669 7717.07793944942 0.9106783336630717 1.4142701855575928 1.1719009823979707 1.2416449887970509 1.208651153171772 1.2990069154012924 1.2715962808640142 1.0910726227179692 0.6583117356194698 1.0 12.91383896113365 -8.052639192459063 5.096436597705805 0.8335585311444945 1.2244432296982022 0.5335992960211606 0.14304648214312998 0.14489499367767544 8.164083862513452 0.0909383611449614 0.034096855063833115 8.858512606294122e-09 8.052639192459063 0.39088469855370767 YHGHS(ph)MSDPGVSYR ddPTM_A459_Selumetinib_30min_R2 3 YHGHSMSDPGVSYR 14 0 P08559-3;P08559;P08559-2;P08559-4;Q5JPU3;P29803 P08559-3 PDHA1;PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial 1 Y(0.008)HGHS(0.989)MS(0.003)DPGVSYR;Y(0.039)HGHS(0.936)MS(0.025)DPGVSYR;YHGHS(0.828)MS(0.172)DPGVSYR 97.291 0.01332 56617000.0 246601.0 185556.0 253452.0 244140.0 232824.0 181075.0 257064.0 218409.0 199350.0 225177.0 True False 232895.90364201818 199787.54854342103 237145.17425767204 210887.71083500926 203574.56764703122 206016.43761480873 269017.98536265263 219044.5340304434 239225.57030438868 218675.55492989207 1.0650294392378938 0.9136254329272123 1.0844612893914978 0.9643863069313824 0.930943413918843 0.9421100482898426 1.2302151717365046 1.0016873358371934 1.0939749089974184 1.0 17.73843242937916 YHGHSMS(ph)DPGVSYR ddPTM_A459_Selumetinib_30min_R2 2 YHGHSMSDPGVSYR 14 0 P08559-3;P08559;P08559-2;P08559-4;Q5JPU3;P29803 P08559-3 PDHA1;PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial 1 YHGHS(0.006)MS(0.994)DPGVSYR;YHGHS(0.405)MS(0.595)DPGVSYR 160.48 0.00029039 15777700.0 87343.0 57648.0 70743.0 71780.0 76042.0 54013.0 72196.0 67705.0 58757.0 62945.0 True False 82488.8257217319 62069.41623246435 66191.47239915472 62003.44017259346 66488.92413589475 61452.80046880395 75553.25705365995 67902.01034083389 70510.04180775005 61127.61429924927 1.3494527255375806 1.0154071436291379 1.082840761216615 1.0143278268485434 1.0877068391774505 1.0053197916078114 1.2359922421279224 1.110823825193319 1.1534891818707214 1.0 15.899536641960475 -7.244590336135398 24.886432989065092 1.13431165251498 1.084793094361502 0.015746928098683277 0.10744804206236426 2806.8214618274833 4145744.6415000847 0.039665322488520866 0.030647784717699994 5.693897749560366e-08 7.244590336135398 -0.04951855815347783 YHGLS(ph)PSSQAR ddPTM_A459_Selumetinib_30min_R2 1 YHGLSPSSQAR 11 0 V9GYB6;O94761 V9GYB6 RECQL4 ATP-dependent DNA helicase Q4 1 Y(0.153)HGLS(0.803)PS(0.042)S(0.002)QAR 87.641 0.031769 3058300.0 16837.0 11150.0 14838.0 14902.0 18171.0 13952.0 13505.0 14686.0 10420.0 16363.0 True False 15901.26694385126 12005.169147099248 13883.33923439288 12872.321892616143 15888.196529198896 15873.76135635408 14133.009259649814 14728.73382860182 12504.291159125813 15890.557673820264 1.000673939219178 0.7554907381808127 0.873684833431977 0.8100610536673188 0.9998514120983144 0.998943000125549 0.8893966813344748 0.9268858985904219 0.7869007127249326 1.0 13.955882136025497 -6.249622684454933 24.94875021659876 0.9310579368861023 0.8534933788361458 0.15446098607812064 0.08377887905422891 1367.7261321693904 2887697.693421337 0.02448861761049756 0.031335046428362844 5.628301002734765e-07 6.249622684454933 -0.07756455804995643 YHGRTHT(ph)GEK ddPTM_A459_Selumetinib_30min_R1 1 YHGRTHTGEK 10 1 Q8N7K0-2;Q8N7K0 Q8N7K0-2 ZNF433 Zinc finger protein 433 1 YHGRT(0.212)HT(0.788)GEK 96.604 0.029791 90466000.0 6015.9 7709.3 8260.4 8671.9 7041.7 6696.4 7417.1 5844.8 3869.1 5690.1 True False 6156.058765096318 6806.691572043667 7138.6830511292865 7157.515456723866 6404.779478313107 6629.040295844725 6857.6221754585295 5689.776917413928 6565.580112116687 6420.479761267567 0.9588160065909085 1.0601531077328483 1.1118613120150898 1.1147944893312443 0.997554655798594 1.0324836371006616 1.0680856307387003 0.8861918624427874 1.0225996119050882 1.0 12.648465389383645 -7.728692755467306 24.999539229786503 0.9657966345584886 1.0518497865471086 0.3009947343767012 0.05532418115413333 212.14023812795 161952.85096357897 0.02634309761284727 0.015207917422238234 1.8677005407829887e-08 7.728692755467306 0.08605315198861996 YHPGYFGK ddPTM_A459_Selumetinib_30min_R2 1 YHPGYFGK 8 0 P46776;E9PLL6 P46776 RPL27A 60S ribosomal protein L27a 0 97.602 0.032382999999999995 0.0 177760.0 154380.0 194270.0 189230.0 207440.0 156600.0 173590.0 173000.0 167320.0 162760.0 False True 167880.8108296607 166220.44959006147 181770.87970518335 163456.5475600424 181379.53266287036 178170.22852673806 181662.2789620595 173503.40135830813 200788.67531141394 158060.69589873435 1.0621287593040705 1.0516241792112244 1.1500068291590944 1.0341378457852992 1.14753090027565 1.1272266486849292 1.1493197466272458 1.0977011101448493 1.2703264032195225 1.0 17.27011913953021 -6.285044655060352 24.10327797204108 1.137528103033013 1.0782374111173394 0.14207800671092874 0.06822327498463743 934.1722199332655 953878.083370035 0.019927922247738775 0.02260952125605432 5.18746697574159e-07 6.285044655060352 -0.05929069191567371 YHS(ph)LGNISR ddPTM_A459_Selumetinib_30min_R2 2 YHSLGNISR 9 0 G5E9A7;Q09019;M0R0L4;R4GMW3 G5E9A7 DMWD Dystrophia myotonica WD repeat-containing protein 1 Y(0.493)HS(0.507)LGNISR;Y(0.305)HS(0.695)LGNISR 94.538 0.015332 10471700.0 14849.5 12168.2 13961.900000000001 19762.7 19602.2 9023.5 12134.4 15743.0 11854.7 13968.0 True False 14024.224237258371 13101.461813070231 13063.606554567325 17070.98616744096 17139.59639010856 10266.405217822601 12698.673643857444 15788.80952360604 14225.971247993162 13564.707546777574 1.0338759010392347 0.9658491912111005 0.9630584743178418 1.258485382642572 1.263543377621896 0.7568467792187296 0.9361553575752641 1.163962397947667 1.0487488358252646 1.0 13.727570323198574 -6.738491641288214 24.99991043420706 0.9885783310601922 1.0912126502266417 0.15239503303940427 0.1356699643362242 593.6519840570156 646739.563569525 0.04961669239064678 0.04958552205892483 1.826031893724657e-07 6.738491641288214 0.1026343191664495 YHSDFNR ddPTM_A459_Selumetinib_30min_R1 2 YHSDFNR 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3;K7EII0 Q15424-2 SAFB Scaffold attachment factor B1 0 ; 173.85 5.1891e-08 5354900.0 1488.84 1502.24 1871.6100000000001 1656.33 1635.29 1489.94 1640.44 1640.3 1082.97 1286.53 False True 1523.5270752216632 1326.3570424275704 1617.4556420178303 1367.083058664819 1487.378308233899 1474.9525563572806 1516.7002900741793 1596.7939155546921 1837.7209930007002 1451.6686573634156 1.0495005643979116 0.913677536330197 1.1142044252408978 0.9417321588714158 1.0245990369009832 1.016039403258974 1.044797848586796 1.0999713381253677 1.265936950335795 1.0 10.50349648115751 -7.7532296912364735 2.7739508102184343 1.144633469915747 1.0094478575743915 0.2820416769207583 0.07939225598395074 0.29378107114098817 4.558839943653428 0.04554377765993362 0.020766330399377968 1.7651040391682722e-08 7.7532296912364735 -0.1351856123413555 YHSDFNR ddPTM_A459_Selumetinib_30min_R2 3 YHSDFNR 7 0 Q15424-2;Q15424;Q15424-4;Q15424-3;K7EII0 Q15424-2 SAFB Scaffold attachment factor B1 0 ;; 143.02 0.0043613 13229000.0 10169.97 7472.97 8614.8 9352.31 10646.35 6424.26 9053.35 8763.900000000001 6679.14 9995.800000000001 False True 9604.763781015554 8046.122769614189 8060.533147085038 8078.509244365378 9308.860333423412 7309.143501374089 9474.34871387269 8789.401498058254 8015.154630764254 9707.195281792609 0.9894478788359001 0.8288823430497967 0.8303668477962787 0.832218680046327 0.9589649804288642 0.7529614156504663 0.9760129923051348 0.9054522179587936 0.8256921178662134 1.0 13.244838799920066 -11.421880476733616 2.4594017934874106 1.0699620037113735 0.8760252316563435 0.19751438028992974 0.07383188955877036 30457063.16780745 16746360.0620902 12340497.037078626 0.018341027891312405 3.78546751176999e-12 11.421880476733616 -0.19393677205503002 YHTINGHNAEVR ddPTM_A459_Selumetinib_30min_R1 5 YHTINGHNAEVR 12 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ;;;; 161.93 0.0002541 104548100.0 9770.029999999999 10731.7 11662.41 11878.199999999999 12128.46 9460.39 10867.12 9906.970000000001 5186.37 7530.86 False True 9997.652689830946 9475.227574968021 10078.718779032577 9803.895351429033 11031.442934453522 9365.22706594686 10047.404389231491 9644.20497322616 8800.891092522459 8497.519237788343 1.1765378118088314 1.1150580904638407 1.1860777830561022 1.1537361760631568 1.2981956999163777 1.1021130760492819 1.182392661678344 1.1349435880460879 1.0357012259984097 1.0 13.05282600759325 -8.255081055437682 2.0945073579639604 0.9993577881172575 1.1735418319475455 0.6069647149661781 0.0497637916904306 0.2108552202199596 1.6911460244846543 0.045647800190154214 0.013323584608257664 5.558005146253182e-09 8.255081055437682 0.17418404383028796 YHTINGHNAEVR ddPTM_A459_Selumetinib_30min_R2 2 YHTINGHNAEVR 12 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 ; 196.16 9.1441e-05 15339000.0 22749.0 14394.8 20530.1 20528.2 26401.0 15524.099999999999 14134.099999999999 18343.9 11342.3 15020.5 False True 21484.70165146238 15498.834873422787 19209.215717482763 17732.223746879805 23084.270352065392 17662.403861251158 14791.363656187817 18397.277712003885 13611.076930340945 14586.819137054159 1.4728846261544355 1.0625232771997482 1.316888592159655 1.215633345438248 1.5825431257610911 1.2108468402397783 1.0140225581198896 1.2612261480140115 0.9331079519430946 1.0 13.832377696971717 -7.003718268500734 24.998744079058326 1.07936894035092 1.3169927003469635 0.4168954883380115 0.15325848655943186 175.52038745502134 1180069.5866131028 0.05358010350928997 0.04625392398663126 9.914749167561279e-08 7.003718268500734 0.23762375999604357 YHTINGHNCEVK ddPTM_A459_Selumetinib_30min_R2 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 107.34 0.0048057 6313900.0 33024.0 26064.0 28779.0 27464.0 32733.0 23778.0 29733.0 30048.0 23811.0 31212.0 False True 31188.658285546342 28063.024991030914 26927.390472206014 23723.355821957426 28620.787903267177 27053.203664807006 31115.643414821785 30135.43470528581 28573.865334927497 30310.82846148494 1.028960931410266 0.9258415693483851 0.8883752717752945 0.7826693306024936 0.9442430100396217 0.892526038975896 1.0265520605733196 0.994213495140128 0.9426949636574747 1.0 14.887545664233281 -7.251726086450658 24.771292510157558 0.9903829216040675 0.9058626170059014 0.29742339802203377 0.06031183748528641 783.5546040833872 1998260.1733587603 0.02444253314367288 0.01868272497585393 5.601107571527648e-08 7.251726086450658 -0.08452030459816606 YHTVNGHNCEVR ddPTM_A459_Selumetinib_30min_R1 2 YHTVNGHNCEVR 12 0 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8VZ49;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 ; 108.68 0.0044876 94079000.0 1216.69 1286.5 1486.96 1743.4299999999998 1579.61 1233.94 1427.51 1367.28 673.89 1154.6399999999999 False True 1245.03650973338 1135.8759819223762 1285.038999286621 1438.9726787343136 1436.7345544027958 1221.5276839278781 1319.831771405106 1331.015292848637 1143.5421110217662 1302.849291146022 0.9556258871954496 0.8718398894190045 0.9863297374604743 1.1044812999579972 1.1027634310174161 0.9375817235571343 1.0130348769995843 1.021618771943944 0.8777240151973948 1.0 10.347454492519521 -5.443454129882781 6.47275713195394 1.012829331676235 0.9157878261672013 0.23642655210544905 0.06647878645865643 0.33226854905761 22.222522466749986 0.018137385389530993 0.03799431780168335 3.602017928443269e-06 5.443454129882781 -0.09704150550903357 YHTVNGHNCEVR ddPTM_A459_Selumetinib_30min_R2 3 YHTVNGHNCEVR 12 0 F8W6I7;P09651-2;P09651;P09651-3;F8VTQ5;F8VZ49;A0A2R8Y4L2;H0YH80 F8W6I7 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 ;; 129.34 0.0013100999999999998 67488000.0 5851.719999999999 4357.41 6488.800000000001 7432.7 6924.700000000001 2658.2000000000003 4184.17 4698.88 3728.5800000000004 4969.950000000001 False True 5526.504828691171 4691.609335718541 6071.31767247126 6420.353437877332 6054.757278396549 3024.3429212629308 4378.742195775565 4712.552962858543 4474.400185229683 4826.454630019125 1.1450443964225707 0.9720612116683153 1.2579249444736214 1.3302421611807198 1.2544937728695809 0.6266179117177253 0.9072378239175977 0.976400551565916 0.9270573388176557 1.0 12.236748101911155 -6.734565369415522 24.999998624171358 0.8872235548206732 1.1910849704677822 0.5790206827144888 0.12981449171707296 173.01999565680507 160954.35485750582 0.045749707022889316 0.04573799262931339 1.8426151201713915e-07 6.734565369415522 0.303861415647109 YHYLGGR ddPTM_A459_Selumetinib_30min_R2 1 YHYLGGR 7 0 Q8NCW5-2;Q8NCW5 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 88.734 0.044803 2757500.0 12072.0 13108.0 13694.0 12367.0 13926.0 9313.5 13381.0 12097.0 10172.0 11155.0 False True 11401.086568044915 14113.341451136948 12812.942948899863 10682.593265735053 12176.491379980402 10596.350085464708 14003.243013948484 12132.200267233846 12206.68422942685 10832.926165829303 1.0524475468140622 1.3028189461546575 1.1827776496175335 0.9861225953363875 1.124026065864748 0.9781613871687932 1.2926556315060493 1.1199375017899496 1.1268132028750313 1.0 13.403135372700635 -12.122742175144642 1.466543960824827 0.0002165756886790946 1.131876524560975 0.12125311443241849 0.10443823440265056 1075693.1208255957 58939.02754957295 3550321.7331370534 0.029547822087891026 7.538029363426988e-13 12.122742175144642 1.1316599488722958 YIASVQGSTPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 YIASVQGSTPSPR 13 0 P49792;F8WBP7 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 YIASVQGSTPS(1)PR;YIASVQGST(0.003)PS(0.997)PR 174.95 0.00011021 21652700.0 42672.0 50400.0 49409.0 52271.0 59335.0 43641.0 37813.0 41375.0 35281.0 45710.0 True False 40300.46106955041 54265.51793845757 46230.07873245169 45151.59962749552 51880.80683836974 49652.151616445524 39571.37942503803 41495.39440000001 42338.18583350456 44390.23353115711 0.907867741701874 1.222465250162946 1.0414470719106088 1.0171516578259048 1.1687437238183274 1.118537742803158 0.8914433711474672 0.934786575765022 0.9537725410655424 1.0 15.43795467806053 -7.257855125930914 24.964214388827756 0.9395661682399818 1.0853839691411704 0.37674296813080865 0.08433868231674245 301.81117879688975 2102115.237935621 0.031933536442622396 0.023742739518881954 5.522616346832769e-08 7.257855125930914 0.14581780090118857 YIDLEPDTPLS(ph)PEELKEK ddPTM_A459_Selumetinib_30min_R1 1 YIDLEPDTPLSPEELKEK 18 1 Q5VTI5;A0A1B0GUN5;Q9Y2H5 Q5VTI5 PLEKHA6 Pleckstrin homology domain-containing family A member 6 1 YIDLEPDT(0.001)PLS(0.999)PEELKEK 100.19 0.0015658 3393000.0 953.8 1237.3 1471.3 1627.2 1200.2 959.73 1177.6 1045.4 895.99 1069.4 True False 976.0216842282736 1092.4363407948351 1271.505541272399 1343.0400663269966 1091.642121912521 950.075987565119 1088.7726839088007 1017.6725960622296 1520.4295894795778 1206.6679068381115 0.8088569180444923 0.9053330536132326 1.0537327909915035 1.1130154856328511 0.9046748618457932 0.7873549815828347 0.9022968769939053 0.8433742128179117 1.2600232266586344 1.0 10.236812964002125 -8.252503606852269 24.98787299771329 1.1300116208535125 0.9207441854938502 0.3701381920619875 0.11206867047372111 658.532242512122 1841523.7695511994 0.08301784517171466 0.03031749006751466 5.591088841048812e-09 8.252503606852269 -0.2092674353596623 YIDQEELNK ddPTM_A459_Selumetinib_30min_R1 4 YIDQEELNK 9 0 P07900;P07900-2;Q14568;P08238;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 ;;; 199.89 0.0053041 89846300.0 13829.400000000001 14746.900000000001 16141.099999999999 16707.4 14396.4 15518.0 14448.199999999999 14679.699999999999 9955.0 13350.3 False True 14151.598112671927 13020.326092352192 13949.227276715772 13789.766226740203 13094.248161890857 15361.90300921666 13358.36064168745 14290.346669614226 16892.90791556736 15063.941047934204 0.9394353089699995 0.8643372973195309 0.9260011860328344 0.9154155730469528 0.8692445171037455 1.0197798146138732 0.8867772782156068 0.9486459502292022 1.1214135704470227 1.0 13.87881163870216 -8.106824965657575 5.550416272539293 1.0583911424533288 0.9175951815820617 0.5645414496828238 0.049595657661576385 0.1548112474344865 6.603070879942634 0.0329212487014807 0.012070422933004367 7.819428886796904e-09 8.106824965657575 -0.1407959608712671 YIDQEELNK ddPTM_A459_Selumetinib_30min_R2 2 YIDQEELNK 9 0 P07900;P07900-2;Q14568;P08238;Q58FF8 P07900;P08238;Q58FF8 HSP90AA1;HSP90AA2P;HSP90AB1;HSP90AB2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 ; 166.33 0.01269 41150900.0 102346.0 91855.0 108642.0 123151.0 111638.0 79900.0 91026.0 103013.0 80287.0 102018.0 False True 96658.0190434995 98899.98313962335 101652.092000466 106377.62135267547 97613.03638361712 90905.49974001512 95258.88936459713 103312.7507752797 96346.6434062126 99072.47526540337 0.9756293943859198 0.9982589298862481 1.026037673209962 1.073735374711316 0.9852689773029635 0.9175656457203689 0.9615071099153413 1.0427997332106334 0.9724864867675045 1.0 16.59619667698376 -6.497797563591085 24.850767912586935 0.977234352236708 1.019017820103367 0.20325126789021464 0.03742206961731307 1177.4677125615465 1166651.998039402 0.012556572870995873 0.01417318887726498 3.178355242792589e-07 6.497797563591085 0.041783467866659096 YIEIDS(ph)DEEPR ddPTM_A459_Selumetinib_30min_R1 2 YIEIDSDEEPR 11 0 E7EW05;Q9NVU7-2;Q9NVU7 E7EW05 SDAD1 Protein SDA1 homolog 1 YIEIDS(1)DEEPR;YIEIDS(1)DEEPR 171.49 0.00030256 8978000.0 2514.1000000000004 3264.1000000000004 2464.3 1790.1100000000001 2283.3 2095.23 2660.6000000000004 2649.8 1255.4299999999998 2657.9 True False 2572.6736384129827 2881.9376545610776 2129.6615954309614 1477.500893026437 2076.775918149356 2074.153888516628 2459.908799938651 2579.518696236556 2130.3730170206645 2999.067355138411 0.8578245613607601 0.9609446248759131 0.7101079579897179 0.4926534545797983 0.6924739167965469 0.6915996351208666 0.8202245927301366 0.8601069568567618 0.7103451722651773 1.0 11.5502982082802 -10.45365719716409 8.44696060982929 1.0001060548748897 0.7534554482831155 0.26567027761539297 0.12209726200193655 5.615898519182088e-10 0.0 0.13132461501158949 0.03185089758449166 3.5183804822796866e-11 10.45365719716409 -0.24665060659177418 YIEIDS(ph)DEEPR ddPTM_A459_Selumetinib_30min_R2 4 YIEIDSDEEPR 11 0 E7EW05;Q9NVU7-2;Q9NVU7 E7EW05 SDAD1 Protein SDA1 homolog 1 YIEIDS(1)DEEPR;YIEIDS(1)DEEPR;YIEIDS(1)DEEPR;YIEIDS(1)DEEPR 161.25 0.00060989 38298600.0 117912.0 103764.3 119966.0 126106.0 135516.0 112090.0 129388.0 147222.0 134620.0 94218.0 True False 111358.92307913463 111722.68815518808 112247.51816910456 108930.14525501635 118491.2685515886 127529.38004828889 135404.79837745792 147650.39164608595 161547.76159707454 91497.68153223727 1.2170682493184233 1.221043924657533 1.2267799171452942 1.1905235567814592 1.2950193553247653 1.3937990330755716 1.4798713596885065 1.6137063712818172 1.765594044480314 1.0 16.48144756683333 -6.870881816007997 1.766016612239695 1.517001995611969 1.216119493288611 0.25888651829800313 0.18474855918984737 0.4011814865223685 2.5705881823368504 0.07769780054964305 0.06532671951711266 1.34622665111979e-07 6.870881816007997 -0.3008825023233579 YIEIDS(ph)DEEPRGELLSLR ddPTM_A459_Selumetinib_30min_R1 6 YIEIDSDEEPRGELLSLR 18 1 E7EW05;Q9NVU7-2;Q9NVU7 E7EW05 SDAD1 Protein SDA1 homolog 1 YIEIDS(1)DEEPRGELLSLR;YIEIDS(1)DEEPRGELLSLR;YIEIDS(1)DEEPRGELLSLR;YIEIDS(1)DEEPRGELLSLR;YIEIDS(1)DEEPRGELLSLR;YIEIDS(1)DEEPRGELLSLR 146.2 0.0005066 59954000.0 12230.12 15203.170000000002 15357.730000000001 16500.63 14835.78 13739.330000000002 13202.259999999998 13289.779999999999 7543.35 10833.34 True False 12515.058000329094 13423.175788638022 13272.234619972383 13619.104725686588 13493.886318469693 13601.12481451353 12206.402898999499 12937.291863110682 12800.514005514311 12223.904714667657 1.0238183536650183 1.0981086732892593 1.085760641118776 1.1141370162469286 1.1038932839748141 1.1126661350847513 0.9985682303587365 1.0583600056688123 1.0471706303596078 1.0 13.577417582272314 -7.254874477280595 24.966016306891824 1.0308880500045197 1.091684178927771 0.522499311800807 0.029654750635506592 439.30930220570065 1670675.9139376658 0.011567540214523712 0.008740991607407078 5.5606495168841715e-08 7.254874477280595 0.06079612892325126 YIEIDS(ph)DEEPRGELLSLR ddPTM_A459_Selumetinib_30min_R2 6 YIEIDSDEEPRGELLSLR 18 1 E7EW05;Q9NVU7-2;Q9NVU7 E7EW05 SDAD1 Protein SDA1 homolog 1 YIEIDS(1)DEEPRGELLSLR;YIEIDS(0.999)DEEPRGELLS(0.001)LR;Y(0.001)IEIDS(0.998)DEEPRGELLS(0.001)LR;Y(0.003)IEIDS(0.996)DEEPRGELLS(0.001)LR;YIEIDS(1)DEEPRGELLSLR;Y(0.001)IEIDS(0.996)DEEPRGELLS(0.003)LR 95.365 0.0022102 17996600.0 30697.210000000003 28734.3 30981.47 30834.0 34046.83 24239.179999999997 24417.7 27406.779999999995 25670.28 27315.2 True False 28991.181958867965 30938.128414663137 28988.155950274053 26634.356008383187 29769.56283287795 27577.907023631775 25553.17143275465 27486.52919236333 30805.05328755125 26526.539202587253 1.0929123372430098 1.1663085100692518 1.0927982624829817 1.0040644882083003 1.1222558135278495 1.0396345642005942 0.9633058891550517 1.0361897940189064 1.1612918312595673 1.0 14.695148845506196 -5.5316470073809025 10.145989237625498 1.0476040068883707 1.1296327547274008 0.2584894139126217 0.05714303510115128 0.2450033498205911 252.6807515352948 0.01556257437037653 0.02770665778147674 2.9400383311269584e-06 5.5316470073809025 0.08202874783903003 YIES(ph)PDVEK ddPTM_A459_Selumetinib_30min_R2 1 YIESPDVEK 9 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 1 YIES(1)PDVEK 103.08 0.015556 2407100.0 24030.0 23345.0 28120.0 28847.0 26741.0 16639.0 20780.0 21770.0 20415.0 21098.0 True False 22694.508799711683 25135.486433993898 26310.789814741074 24917.988836149372 23381.556512426832 18930.871216196636 21746.311174788832 21833.347095782483 24498.57044275945 20488.845920812782 1.1076518847095416 1.2267887869887786 1.2841518705557886 1.216173372207237 1.1411846525077143 0.9239598603729291 1.0613731617113047 1.0656211277182743 1.195702800316027 1.0 14.32255110322456 -6.527230697995306 24.980407014516835 1.0517838539790794 1.2107872887743798 0.5020514049631466 0.0750472919084601 106.49811403436665 611296.6477634148 0.025489301597906595 0.02559037912162432 2.970087896688219e-07 6.527230697995306 0.15900343479530044 YILGNPLT(ph)PGVTQGPQIDK ddPTM_A459_Selumetinib_30min_R2 1 YILGNPLTPGVTQGPQIDK 19 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 YILGNPLT(0.999)PGVT(0.001)QGPQIDK 128.72 0.00075407 5025800.0 27975.0 18690.0 24234.0 30110.0 24303.0 25348.0 26301.0 28131.0 24804.0 22316.0 True False 26420.26149279793 20123.46290217801 22674.810823984164 26008.966057352853 21249.839868423373 28839.456913765986 27524.048614442785 28212.856552662266 29765.493081665692 21671.67909606874 1.21911465076975 0.9285603950193422 1.0462876791165385 1.2001361750539625 0.9805350002749954 1.3307439993884687 1.2700468889572876 1.301830671615108 1.3734742448758932 1.0 14.403523315617209 -6.767652494319539 24.998564362512596 1.275010326852158 1.0721603265661752 0.3357307897784372 0.12523378982966596 151.89406696709293 611143.7921697213 0.04133765028615444 0.037355300029551605 1.7074480765876516e-07 6.767652494319539 -0.20285000028598277 YILGNPLT(ph)PGVTQGPQIDKEQYDK ddPTM_A459_Selumetinib_30min_R2 1 YILGNPLTPGVTQGPQIDKEQYDK 24 1 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 YILGNPLT(0.96)PGVT(0.04)QGPQIDKEQYDK 82.831 0.01193 0.0 7084.9 7630.2 7414.8 5982.5 8073.5 6441.0 5517.2 4777.9 4689.4 8404.1 True False 6691.14962110184 8215.411805040054 6937.739840623827 5167.673179611869 7059.234751994245 7328.1892844234935 5773.760732124399 4791.802897976076 5627.411032783549 8161.451796525872 0.8198479618479272 1.006611569835792 0.8500619759314209 0.6331806286979015 0.8649484096688761 0.8979026608406757 0.7074428515992884 0.5871262879988861 0.6895110297874942 1.0 12.994610092906358 -5.5286537448854975 24.798931172393043 0.7569614634865625 0.9170065347762615 0.17493185127914646 0.12618617924208053 195.01110061669024 837411.0695033505 0.03476671606326007 0.06044669872064497 2.9603717766402465e-06 5.5286537448854975 0.16004507128969903 YILGNPLTPGVT(ph)QGPQIDK ddPTM_A459_Selumetinib_30min_R2 1 YILGNPLTPGVTQGPQIDK 19 0 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 1 YILGNPLT(0.118)PGVT(0.882)QGPQIDK 179.87 1.2586e-12 6276000.0 51445.0 34052.0 41203.0 42210.0 50293.0 40924.0 48026.0 49294.0 44933.0 37808.0 True False 48585.89285065202 36663.67890556262 38552.04383843444 36460.925183688596 43974.743714875396 46560.909528915836 50259.30416171361 49437.43737893901 53920.85553291748 36716.384803018795 1.323275510683103 0.9985645128805862 1.0499956366963643 0.9930423536875778 1.197687189269784 1.268123476173167 1.3688522013088098 1.3464680045208126 1.4685774708539427 1.0 15.16413639354298 -6.6373500616716665 2.6209607992069968 1.32125090999623 1.0823267423117815 0.2875613141352218 0.14319923328666553 0.2975259878431908 4.1501145175932965 0.049858532327455005 0.04971436789866542 2.3048885917193227e-07 6.6373500616716665 -0.23892416768444846 YILGNPLTPGVTQGPQIDKEQYDK ddPTM_A459_Selumetinib_30min_R2 3 YILGNPLTPGVTQGPQIDKEQYDK 24 1 P00352 P00352 ALDH1A1 Retinal dehydrogenase 1 0 ;; 108.69 1.2930000000000002e-06 13437800.0 55706.0 60040.0 59913.0 53167.0 57874.0 42891.0 40215.0 42876.8 32685.7 54938.0 False True 52610.08352878647 64644.87494097208 56058.26280834215 45925.56288180934 50603.350719875474 48798.84592426765 42085.07718451077 43001.56438936366 39223.753314763744 53351.79719393372 0.9860976817247388 1.2116719274889285 1.0507286681378405 0.8608062951444723 0.948484463155615 0.914661707587542 0.7888221090571993 0.8060002971043885 0.7351908534999383 1.0 15.703249249645166 -5.70100024707465 3.858123693523422 0.8579082348349246 1.1059114551126614 0.5564405283522298 0.08949827744295266 0.153992622439177 4.5918027220936946 0.02535579756831846 0.044816639220940466 1.990672206472731e-06 5.70100024707465 0.2480032202777368 YIQHTYR ddPTM_A459_Selumetinib_30min_R1 2 YIQHTYR 7 0 J3KTF8;J3QQX2;P52565;J3KRY1;P52565-2 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 0 ; 120.65 0.013026 28218000.0 10374.7 10698.099999999999 10999.8 10361.2 10214.599999999999 8471.400000000001 8511.8 9278.1 6593.700000000001 7203.9 False True 10616.41032434795 9445.561478588243 9506.087577576376 8551.810923812234 9290.691233534099 8386.185407415787 7869.748073110503 9032.01464848381 11189.027315206076 8128.590736928252 1.3060579217154473 1.1620171053362278 1.1694631806704383 1.052065628665654 1.1429645721153625 1.0316899544858718 0.9681565141861769 1.111141517735823 1.3765027268963408 1.0 12.988789536952751 -4.281568537986363 1.0400100517884787 1.0974516853400174 1.6701178133773193 0.24488945096890313 0.10771660362770215 6.735806343718994 2.8969319493561465 0.03484060677957937 5.496919496188558 5.229154360081211e-05 4.281568537986363 0.572666128037302 YIQHTYR ddPTM_A459_Selumetinib_30min_R2 4 YIQHTYR 7 0 J3KTF8;J3QQX2;P52565;J3KRY1;P52565-2 J3KTF8 ARHGDIA Rho GDP-dissociation inhibitor 1 0 ;;; 124.59 0.0090058 29774200.0 102712.0 74249.0 93948.0 105304.0 100680.0 84558.0 97284.0 97533.0 70827.0 83597.0 False True 97003.6782287136 79943.65955183584 87903.48796284827 90961.4135404679 88031.6783093802 96205.09695890105 101807.89876458902 97816.80488254255 84994.3790717276 81183.33739890932 1.1948717721725102 0.9847298979471354 1.0827774612285062 1.1204443726366187 1.0843564840999365 1.1850350089228228 1.2540491931778697 1.2048877025331148 1.046943643793455 1.0 16.308896029142666 -6.7494067382106335 24.493760089687697 1.1582302203305563 1.0883050743859741 0.03792973519173104 0.08524175065289955 363.30599478807795 739547.071782908 0.02781202616754357 0.027600250348402352 1.7807102632290354e-07 6.7494067382106335 -0.06992514594458221 YIS(ph)PDQLADLYK ddPTM_A459_Selumetinib_30min_R2 2 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733 ENO1 Alpha-enolase 1 Y(0.045)IS(0.954)PDQLADLY(0.001)K;YIS(1)PDQLADLYK 119.62 0.0042332 1975360.0 14337.0 15669.3 17422.1 15124.8 17392.9 12761.3 13061.2 11513.7 10962.099999999999 15932.9 True False 13540.206935558326 16871.08492525938 16301.181053748242 13064.776148264707 15207.848407501162 14519.053239452502 13668.571680276798 11547.20296080435 13154.82630666535 15472.875778354266 0.8750931067707762 1.0903651762564484 1.0535327296140211 0.8443663825273927 0.9828714859054279 0.9383551866786062 0.8833892209875043 0.7462868006061469 0.8501862546501056 1.0 13.917453739593883 -7.239159422027142 2.711471488916081 0.8447875954731817 0.972724901815136 0.19950693536695097 0.09003099538278275 0.3738544531311437 5.464709160403356 0.04084486252897021 0.02797932043823565 5.7655478120843645e-08 7.239159422027142 0.12793730634195433 YISENES(ph)PRPSQK ddPTM_A459_Selumetinib_30min_R1 1 YISENESPRPSQK 13 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 YISENES(0.807)PRPS(0.193)QK 165.78 0.0016573 5878000.0 1411.9 1891.8 1752.8 1918.7 1865.9 1458.7 1552.7 1104.7 665.47 1314.6 True False 1444.7945229208415 1670.30717652604 1514.7793874412157 1583.6350634596893 1697.1296744514016 1444.026802393631 1435.5785889140582 1075.3997674286836 1129.253985994235 1483.3417152883685 0.9740132755856372 1.1260434189308324 1.0211938165217282 1.0676131110839981 1.1441258996221728 0.9734957141098843 0.96780032147547 0.7249845105445719 0.761290520151456 1.0 10.534635272314885 -7.43365674977416 2.293991325629906 0.8109574010800562 1.0618705726219366 0.5530045238436854 0.08742197169192084 0.20014922662030424 2.064665023817632 0.044437186963201494 0.025410140586953595 3.68420044118974e-08 7.43365674977416 0.2509131715418804 YISENESPRPS(ph)QK ddPTM_A459_Selumetinib_30min_R2 1 YISENESPRPSQK 13 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 YISENES(0.397)PRPS(0.603)QK 160.46 0.0017277000000000002 5448300.0 17745.0 19134.0 23405.0 23541.0 23114.0 21424.0 20080.0 20304.0 17464.0 25990.0 True False 16758.803938863246 20601.516274493006 21899.14778143723 20334.67518950991 20210.212678218228 24374.961532291418 21013.759787765146 20363.081278491853 20957.28798493025 25239.60116987035 0.6639884610723954 0.816237789806519 0.8676503100841082 0.8056654719958225 0.8007342327716362 0.9657427377017711 0.8325709921617231 0.8067909291213436 0.8303335636677139 1.0 14.623401492928696 -14.522866810213864 0.023651622984639208 2.106574303804225 5.781905457007665e-09 0.4600870173332373 0.06476228729077108 2472.0658772328106 4.402121324943682 279.06251481595933 136.47459969258483 3.0000824456512946e-15 14.522866810213864 -2.1065742980223194 YKDLDEDELLGNLS(ph)ETELK ddPTM_A459_Selumetinib_30min_R1 3 YKDLDEDELLGNLSETELK 19 1 Q9NYL9;H0YNU8 Q9NYL9 TMOD3 Tropomodulin-3 1 YKDLDEDELLGNLS(0.807)ET(0.193)ELK;YKDLDEDELLGNLS(0.779)ET(0.221)ELK;YKDLDEDELLGNLS(0.746)ET(0.254)ELK 158.05 3.5114e-05 85693000.0 19574.3 24392.199999999997 21035.0 21198.7 19874.0 20658.6 22979.0 22172.1 12967.5 20757.0 True False 20030.343105042462 21536.34988437386 18178.562536984235 17496.744993882807 18076.40020903969 20450.79324050801 21245.67552950097 21584.023882869107 22004.900391272706 23421.36314030174 0.855216794387844 0.9195173549619625 0.7761530542901629 0.7470421294043176 0.7717911250833717 0.8731683599285393 0.9071067043464688 0.9215528470129446 0.9395226169995337 1.0 14.515537423728611 -7.332869922385932 1.6131531884746768 0.9516559867411323 0.8153641344860575 0.5993104508748868 0.049845382470712456 0.32357990706046086 1.6364723481259285 0.03308653224127878 0.018855797751012343 4.6465442524863583e-08 7.332869922385932 -0.13629185225507479 YKDLDEDELLGNLS(ph)ETELK ddPTM_A459_Selumetinib_30min_R2 4 YKDLDEDELLGNLSETELK 19 1 Q9NYL9;H0YNU8 Q9NYL9 TMOD3 Tropomodulin-3 1 YKDLDEDELLGNLS(0.815)ET(0.185)ELK;YKDLDEDELLGNLS(0.682)ET(0.318)ELK;YKDLDEDELLGNLS(0.78)ET(0.22)ELK;YKDLDEDELLGNLS(0.68)ET(0.32)ELK 132.48 0.00013539 57806600.0 380022.8 365000.0 355623.1 374449.8 342037.0 277336.1 317467.6 318907.5 234196.1 338369.7 True False 358902.6541278012 392994.32634002046 332742.69691915455 323449.0912780662 299067.2542104236 315536.63036854536 332230.47245011554 319835.46802702115 281041.8639857725 328600.0875709383 1.092217159103225 1.195965373122978 1.012606841887472 0.9843244220324194 0.9101253028298749 0.9602451195343252 1.0110480338152483 0.9733273974188306 0.8552702041660323 1.0 18.325973339198754 -5.4552702832727356 3.3482607114620566 0.9567421762352579 1.1434815680268506 0.6907475314204272 0.049348405300957195 0.1303075414452506 2.827389436363358 0.013368485396500915 0.029895167557931562 3.505336513539831e-06 5.4552702832727356 0.1867393917915927 YKPVCNQVECHPYFNQR ddPTM_A459_Selumetinib_30min_R1 2 YKPVCNQVECHPYFNQR 17 1 P52895;B4DK69;H0Y804;S4R3P0;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 0 ; 115.26 0.0013285 172197000.0 9098.900000000001 11600.6 12328.9 13707.0 11229.8 9137.900000000001 11298.7 10481.3 5618.9 8588.9 False True 9310.886666622608 10242.39635902737 10654.703097800097 11313.329762256719 10214.066572782216 9045.98102254937 10446.429962364444 10203.301875939404 9534.862911781158 9691.368977970687 0.960740086130974 1.0568575381155352 1.0994012426953457 1.167361369479677 1.0539343405456614 0.9334059040690391 1.0779106632004287 1.0528235896427411 0.9838509846704546 1.0 13.242484756105318 -6.532235505850264 24.994845485126525 1.014558216102441 1.0769147071640375 0.1901102413372674 0.05983595945487924 361.57596832634914 965876.2825904345 0.020665612317130298 0.020690714356989458 2.9360570778886866e-07 6.532235505850264 0.062356491061596575 YKPVCNQVECHPYFNQR ddPTM_A459_Selumetinib_30min_R2 1 YKPVCNQVECHPYFNQR 17 1 P52895;B4DK69;H0Y804;S4R3P0;Q04828 P52895;Q04828 AKR1C2;AKR1C1 Aldo-keto reductase family 1 member C2;Aldo-keto reductase family 1 member C1 0 121.95 0.001121 20770000.0 82897.0 71121.0 82891.0 69605.0 91094.0 82800.0 76239.0 80057.0 65536.0 77476.0 False True 78289.91660298369 76575.7520099414 77557.88330489698 60124.67892467761 79649.9573293075 94204.94841643625 79784.26456471249 80289.95261585028 78645.0312288359 75239.06657317726 1.0405487490576346 1.0177658429010956 1.0308193181724876 0.7991151626821493 1.0586250063567737 1.2520749220727352 1.0604100794779874 1.067131163007725 1.045268566062632 1.0 16.199194330236693 -6.508058509659459 24.891852140082584 1.0951608540602342 0.9731920318434597 0.26559905635915415 0.08849155083661787 851.0124157209008 1429349.9539305253 0.02856069580351291 0.03125686590441028 3.104141359262113e-07 6.508058509659459 -0.12196882221677452 YKPVCNQVECHPYFNR ddPTM_A459_Selumetinib_30min_R1 2 YKPVCNQVECHPYFNR 16 1 A0A0A0MSS8;P42330;S4R3Z2;P42330-2 A0A0A0MSS8;P42330-2 AKR1C3 Aldo-keto reductase family 1 member C3 0 ; 115.26 0.0056762 101855000.0 6318.8 8369.400000000001 8024.799999999999 8600.5 7726.700000000001 7083.299999999999 7342.5 6728.8 3794.2999999999997 6301.1 False True 6466.015745755518 7389.506757171504 6935.076237071121 7098.584126379872 7027.821349259679 7012.0484331218195 6788.649313519332 6550.330365777243 6438.649975292536 7109.907562911564 0.9094373855836225 1.039325292457873 0.9754101830025975 0.998407372187121 0.9884546721704114 0.986236230369545 0.9548154112343095 0.9212961361054363 0.9055884226792755 1.0 12.795615087910999 -7.417446827550005 3.320777023200639 0.9352857377709082 0.9860973385985824 0.18478430926837053 0.037793953094611386 0.33344554347124844 6.897686539745347 0.016688865201903873 0.010393796327212344 3.824310733926205e-08 7.417446827550005 0.05081160082767422 YKPVT(ph)NQVECHPYLTQEK ddPTM_A459_Selumetinib_30min_R2 1 YKPVTNQVECHPYLTQEK 18 1 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 1 Y(0.063)KPVT(0.936)NQVECHPYLTQEK 61.222 0.026306 7176600.0 53875.0 45796.0 42920.0 50644.0 44275.0 38620.0 37897.0 43501.0 34647.0 42576.0 True False 50880.843178712756 49308.405942650876 40158.57392776267 43746.199834227096 38712.778676477996 43939.554442545465 39659.28559148087 43627.5807080218 41577.368118064485 41346.720254267006 1.2305895816116594 1.1925590624703108 0.9712638313462912 1.0580331297187342 0.9362962391795226 1.0627095492056804 0.9591881858486225 1.0551642413165627 1.0055783835423724 1.0 15.335485274591353 -5.202051539819013 5.412001857894662 1.0077373728804262 1.2177875953699262 0.7975103740218861 0.04147578526280278 0.08007476966625116 4.924721364381649 0.009702967273932127 0.026569154490162835 6.27983828523815e-06 5.202051539819013 0.2100502224895 YKPVTNQVECHPYLTQEK ddPTM_A459_Selumetinib_30min_R1 1 YKPVTNQVECHPYLTQEK 18 1 O60218;C9JRZ8;C9JRZ8-2 O60218 AKR1B10;AKR1B15 Aldo-keto reductase family 1 member B10;Aldo-keto reductase family 1 member B15 0 84.035 0.006581 43133000.0 3024.2 4927.8 4363.3 4563.4 3521.2 3918.9 3430.1 3345.6 2066.2 2941.4 False True 3094.657975931165 4350.850885127931 3770.7878258912915 3766.4878556272183 3202.7080817183532 3879.4794240765054 3171.364795410647 3256.8638199596294 3506.19049072278 3318.957341662261 0.932418725930729 1.3109089503840559 1.1361362734486777 1.1348406948011018 0.9649741626731226 1.1688849914935977 0.9555304479515563 0.9812912564668478 1.0564132436142566 1.0 11.696514371334157 -6.184244908845592 7.771876553731144 1.0244566092495369 1.1428002251050469 0.20310350187031623 0.10258814474101019 0.45286616758753245 41.068598254130826 0.029190318287782315 0.03775206694421574 6.542671134436676e-07 6.184244908845592 0.11834361585551001 YKSTTSVS(ph)EEDVSSR ddPTM_A459_Selumetinib_30min_R1 2 YKSTTSVSEEDVSSR 15 1 Q96IZ0 Q96IZ0 PAWR PRKC apoptosis WT1 regulator protein 1 YKS(0.004)T(0.013)T(0.04)S(0.396)VS(0.546)EEDVS(0.001)SR;YKS(0.002)T(0.024)T(0.037)S(0.38)VS(0.556)EEDVSSR 142.4 0.0014955 5005200.0 1559.4 1654.1799999999998 4447.7 4757.1 2588.13 2381.68 1874.28 1642.67 1362.1100000000001 1097.22 True False 1595.7309859358036 1460.5078365925806 3843.7267694673064 3926.3617868265455 2354.0340984714653 2357.7224615924183 1732.9015506085143 1599.1010554558477 2311.401185421743 1238.0588748278599 1.2888974978331904 1.1796755924031885 3.104639728867288 3.171385357075582 1.9013910778667702 1.9043702278861632 1.3996923618430162 1.2916195570086981 1.8669557905661964 1.0 10.273864206970782 -7.028401076585823 2.266374474921213 1.410946380032205 2.1903206786454446 0.22851141724212476 0.6401667772263747 0.5328863076826458 5.4606521926193246 0.3077636559530618 0.237880876084584 9.366965559436075e-08 7.028401076585823 0.7793742986132395 YLAEFATGNDR ddPTM_A459_Selumetinib_30min_R2 1 YLAEFATGNDR 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 153.1 0.007847100000000001 7621400.0 17197.0 16446.0 18420.0 18449.0 21176.0 17943.0 12332.0 16945.0 12257.0 19460.0 False True 16241.259585045444 17707.35531777525 17234.87725417961 15936.214373699862 18515.681564158065 20414.48537966321 12905.462435394413 16994.307144604227 14708.742489194336 18898.1392368479 0.8594105155801779 0.9369893562456754 0.9119880554470022 0.843268968122913 0.9797621518237037 1.0802378543099478 0.6828959334912261 0.8992582249298096 0.7783169710441645 1.0 14.205956569237607 -10.38344274922549 4.303387638317369 1.0000013026451255 0.8897289602645011 0.09906644029127754 0.10270818128581809 143657173.52349368 297107739.93368566 3032.5148561011133 0.0257700927239207 4.135778305607391e-11 10.38344274922549 -0.11027234238062444 YLAEFATGNDRK ddPTM_A459_Selumetinib_30min_R1 1 YLAEFATGNDRK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 124.6 0.004076099999999999 18537000.0 4934.4 5357.7 4305.2 4016.7 2906.0 4918.0 4664.1 3122.7 1895.7 2582.9 False True 5049.36191932899 4730.417993272842 3720.577486770838 3315.2587477972256 2643.1528130959714 4868.529385186722 4312.283181911549 3039.875852040871 3216.86444355008 2914.440374576546 1.732532243025434 1.6230965074933634 1.2766009966189202 1.1375284177082938 0.906916070801417 1.6704851564836336 1.4796264900557805 1.043039301321287 1.1037674579352046 1.0 11.50900317106112 -5.235844491503139 3.0367746619477267 1.2124627747841965 1.7136650929999897 0.44223627040067526 0.21605718678434546 0.2645816043169085 4.8798483747335 0.0618230267095869 0.19043417727298487 5.809724099704327e-06 5.235844491503139 0.5012023182157932 YLAEVAAGDDKK ddPTM_A459_Selumetinib_30min_R1 1 YLAEVAAGDDKK 12 1 E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P63104-2 E7EX29;P63104-2 YWHAZ 14-3-3 protein zeta/delta 0 138.24 0.0017018 20081000.0 2327.4 2898.9 2352.3 3154.7 2229.9 2650.4 2127.0 2065.4 1613.6 1789.0 False True 2381.6238916679413 2559.495440337952 2032.870580258999 2603.7908660532044 2028.2059387208196 2623.7393823706584 1966.5586775424756 2010.6188826352864 2738.1613473188827 2018.6355763356848 1.1798186456176347 1.2679333854722106 1.0070517948312168 1.289876635771831 1.0047410055075454 1.2997588138882326 0.9742019315404411 0.9960286572800076 1.3564416378162285 1.0 10.979164769542777 -7.928245834752499 0.016814591914276127 7.753930782154222e-06 2.2269325253483343 0.07316579084403152 0.1416589504609926 907.9917608005874 15.65365948520562 1033.6768371676374 1034.7615361691392 1.1796526978019332e-08 7.928245834752499 2.226924771417552 YLAEVAAGDDKK ddPTM_A459_Selumetinib_30min_R2 2 YLAEVAAGDDKK 12 1 E7EX29;P63104;B0AZS6;B7Z2E6;H0YB80;P63104-2 E7EX29;P63104-2 YWHAZ 14-3-3 protein zeta/delta 0 ; 138.42 0.0016808 20113300.0 110206.0 117506.0 114242.0 110488.0 110082.0 81460.0 100675.0 90665.0 64418.0 111495.0 False True 104081.19170957257 126518.33235865885 106891.79409728484 95439.34379756915 96252.5150144337 92680.37557974512 105356.58698372796 90928.8201396012 77303.39998930578 108275.84965120046 0.9612595241215788 1.1684815475124386 0.9872173198513406 0.8814462699209215 0.8889564508106036 0.8559653503371752 0.9730386538006711 0.8397885625697611 0.7139486805075255 1.0 16.724351967856045 -5.614542959661286 3.5333615073724296 0.8754897432517833 1.0682247350110539 0.43190266150757617 0.08663768754781866 0.19822231548686553 4.821263422649071 0.023668506602027427 0.04455772325797434 2.4291651413084403e-06 5.614542959661286 0.19273499175927056 YLAEVACGDDR ddPTM_A459_Selumetinib_30min_R1 2 YLAEVACGDDR 11 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 ; 151.22 0.0083082 31548000.0 3551.7 4359.0 3423.7 4520.0 3747.8 3765.8999999999996 3988.9 2972.0 2102.0 2724.6 False True 3634.4476995948385 3848.6462535558785 2958.7803450379342 3730.666850908321 3408.8121517278305 3728.018465163618 3688.014061518184 2893.172905583456 3566.94047599423 3074.328949851428 1.1821921983236305 1.2518654692894429 0.962415015862542 1.2134898092439363 1.1087987679043152 1.2126283575945185 1.1996159557670019 0.941074606126086 1.160233837750709 1.0 11.586055824748996 -7.743863221069295 24.994166027380235 1.0379906163289796 1.159315935185722 0.2904122577382938 0.09142825293333862 303.38166931266164 431424.72095423896 0.0417339861794873 0.024027682884167744 1.8035856819411706e-08 7.743863221069295 0.12132531885674247 YLAEVACGDDR ddPTM_A459_Selumetinib_30min_R2 2 YLAEVACGDDR 11 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 ; 160.75 0.0083573 37424000.0 93602.0 87210.0 77975.0 84917.0 97144.0 75740.0 72736.0 82105.0 53462.0 82769.0 False True 88399.97555849403 93898.72657565237 72958.17339276095 73351.15811000443 84939.90224162114 86172.49750073517 76118.36812364966 82343.91195678547 64155.893853088644 80379.24391031162 1.0997861046955364 1.1681961910518341 0.9076742930571576 0.9125634248544409 1.0567392539347393 1.072073999562471 0.9469903475153821 1.0244424798106593 0.7981649332839553 1.0 16.294535386257202 -5.255287217479576 24.77698819242765 0.9703127029321952 1.1339911621536825 0.4258125654137831 0.07836682651966749 422.1727994121186 1700229.4621695033 0.020317792780707767 0.050921503192368 5.555367355975117e-06 5.255287217479576 0.16367845922148727 YLAEVACGDDRK ddPTM_A459_Selumetinib_30min_R1 1 YLAEVACGDDRK 12 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 90.697 0.032545 10103000.0 967.34 1538.3 1280.9 1426.9 1420.2 1429.8 1085.1 1182.4 760.26 923.09 False True 989.8771398840198 1358.1951208637322 1106.9608154800626 1177.718701230329 1291.743160756675 1415.4175101545297 1003.2500333809785 1151.0389110235135 1290.1056928065525 1041.5775931580258 0.950363320396273 1.303978819999126 1.0627732612063947 1.1307066405485244 1.2401794827787684 1.3589170115142692 0.9632023960300072 1.105091851614823 1.2386073791151733 1.0 10.024554602767997 -11.065698204957219 4.953796285869353 0.999164518286225 1.1537149986265283 0.10754849906820652 0.1296845622078227 0.0011733161734206587 0.00010828411269500541 0.12311863694061928 0.029701926940360748 8.596106649882496e-12 11.065698204957219 0.15455048034030328 YLAEVATGDDK ddPTM_A459_Selumetinib_30min_R1 1 YLAEVATGDDK 11 0 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 0 143.4 0.011671 4106800.0 1257.4 1555.0 1143.5 1350.8 1080.5 1239.6 1248.3 1072.8 887.65 1165.8 False True 1286.694973525509 1372.9398771001127 988.2189807958861 1114.9081376564081 982.7689657777695 1227.1307494667465 1154.1397259879047 1044.3458590544858 1506.2772186090774 1315.4417858536292 0.9781466480407832 1.0437100994242563 0.7512449364337331 0.847554144657881 0.7471018302341836 0.9328658726394532 0.877378032536004 0.793912638541263 1.145073263452407 1.0 10.361331688910008 -8.26213955710735 24.999792205147564 1.0725366392694016 0.8705199164902249 0.41304744469383115 0.09585937347379896 63.79757513649037 2277641.828670896 0.07891222778051903 0.025038214570282137 5.4684021186712925e-09 8.26213955710735 -0.2020167227791767 YLAEVATGDDK ddPTM_A459_Selumetinib_30min_R2 1 YLAEVATGDDK 11 0 P31947;P31947-2 P31947 SFN 14-3-3 protein sigma 0 162.36 0.0086462 2637000.0 26131.0 22571.0 21480.0 22859.0 23933.0 16772.0 16925.0 20969.0 15663.0 18849.0 False True 24678.743630681074 24302.123122796133 20098.000185655685 19745.564766025524 20926.32257626533 19082.190758942837 17712.046036251264 21030.01631839518 18796.037660785754 18304.780394416553 1.3482130404694037 1.3276380595207211 1.0979645618576288 1.0787108252906683 1.1432162596525013 1.0424703464218241 0.9676186031520985 1.1488811045670833 1.0268376487334996 1.0 14.159932845036394 -5.2776219277736915 3.3578790341631226 1.064531838737156 1.3490800221587347 0.80784174203475 0.05387253196804755 0.09661062224990842 2.2809222751425686 0.014485407160411464 0.03934042086087946 5.276890377746136e-06 5.2776219277736915 0.2845481834215786 YLCEGTES(ph)PYQTGQLHPAIR ddPTM_A459_Selumetinib_30min_R1 1 YLCEGTESPYQTGQLHPAIR 20 0 H0Y6V4;A0A0G2JQF6;H0Y6P5;Q5TG12;E9PGC5;Q15262;Q15262-2;Q15262-3;Q15262-4 H0Y6V4 PTPRK Protein-tyrosine-phosphatase;Receptor-type tyrosine-protein phosphatase kappa 1 YLCEGT(0.031)ES(0.969)PYQTGQLHPAIR 135.33 7.4167e-05 8368300.0 1478.3 1317.8 1449.6 1233.6 1682.3 1225.3 1496.1 1825.1 474.2 982.57 True False 1512.7415137289336 1163.5113633714006 1252.7522820828312 1018.1749175399348 1530.1362620341893 1212.974594483386 1383.2479724829795 1776.6924192396943 804.6827658023141 1108.6924305422883 1.3644374869493923 1.049444671325391 1.1299367142518324 0.9183565157398258 1.3801269133638465 1.0940586956926284 1.247639051532443 1.6025115444963136 0.7257944075695766 1.0 10.114643478408311 -6.268311886885868 24.94070448119485 1.2047300388638869 1.1118505401653245 0.005386510865099781 0.24079845812127712 2285.8025544877596 8295291.951996816 0.07123457116683513 0.08245418237846573 5.391233141574812e-07 6.268311886885868 -0.09287949869856238 YLCIPAADS(ph)PSQNLTR ddPTM_A459_Selumetinib_30min_R1 1 YLCIPAADSPSQNLTR 16 0 S4R3A4;Q9NRW4;Q9NRW4-2 S4R3A4 DUSP22 Dual specificity protein phosphatase 22 1 YLCIPAADS(0.936)PS(0.061)QNLT(0.003)R 120.92 0.0015657 2457800.0 563.18 839.79 1022.6 997.87 913.34 761.82 686.51 629.44 429.6 608.82 True False 576.3009982424813 741.4669963922211 883.736536739723 823.610736839798 830.7285582632735 754.1567824772167 634.7259979876284 612.7452064907305 728.9998232574322 686.9679774089951 0.8389051850947824 1.0793326920255837 1.286430468088004 1.1989070290381978 1.2092682418713219 1.0978048573990806 0.9239528171045099 0.891955995972029 1.0611845780744638 1.0 9.424099040040826 -7.153826256772872 4.877956135862377 0.9609496101549129 1.134942648769712 0.2709122480860532 0.11888898739609137 0.29856352165850386 11.00592175505302 0.049425653035277024 0.037908232589373536 7.017359777602678e-08 7.153826256772872 0.1739930386147992 YLDEDTIYHLQPSGR ddPTM_A459_Selumetinib_30min_R2 3 YLDEDTIYHLQPSGR 15 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 ;; 148.85 0.00041671 18552100.0 79262.0 84498.0 102733.0 99402.0 95939.0 85160.0 79215.0 75458.0 71575.0 90392.0 False True 74856.93535092585 90978.72489610674 96123.27062723314 85863.27612198581 83886.28511445789 96890.01699448907 82898.65446154469 75677.57028725569 85891.99997259396 87782.14809337881 0.8527580718496011 1.0364148847135473 1.095020715658284 0.978140521585872 0.9556189605342458 1.1037553659705581 0.9443680322491166 0.8621066120044498 0.9784677390353423 1.0 16.421639953981988 -7.492928902939136 24.616809497768113 0.9328197393762035 1.0074351745980217 0.11280130598738558 0.07540159573250926 979.8821961910938 805401.7355992977 0.031325315841932315 0.02108045071152781 3.2141866805359536e-08 7.492928902939136 0.07461543522181813 YLEES(ph)DEDDLF ddPTM_A459_Selumetinib_30min_R1 5 YLEESDEDDLF 11 0 P11388;P11388-2;P11388-3;P11388-4;J3QR57 P11388 TOP2A DNA topoisomerase 2-alpha 1 YLEES(1)DEDDLF;YLEES(1)DEDDLF;YLEES(1)DEDDLF;YLEES(1)DEDDLF;YLEES(1)DEDDLF 176.6 6.9485e-05 37317200.0 17937.59 25205.64 25459.129999999997 28257.199999999997 22795.22 20614.83 21244.829999999998 20256.4 9835.769999999999 14439.53 True False 18355.500946525735 22254.551951015867 22001.91998299079 23322.61047333776 20733.396375822962 20407.463526968044 19642.315368789226 19719.13446993968 16690.583313782015 16292.98432843287 1.1265892470352143 1.365897830772443 1.3503922632881478 1.4314511082317496 1.2725352187101249 1.2525307282935882 1.2055689106943681 1.210283768304364 1.0244030791004504 1.0 13.991963260975618 -7.989666266751481 0.897466420738364 0.9901530733660732 1.318188986326166 0.659490716027528 0.07879779791426375 0.3403011811332699 0.5230882592206921 0.07407600116851124 0.02886671969132729 1.0240796431771021e-08 7.989666266751481 0.3280359129600928 YLGDAFGS(ph)PQTDHGFETDPDPFLLDEPAPR ddPTM_A459_Selumetinib_30min_R1 2 YLGDAFGSPQTDHGFETDPDPFLLDEPAPR 30 0 Q9H8N7 Q9H8N7 ZNF395 Zinc finger protein 395 1 Y(0.001)LGDAFGS(0.843)PQT(0.156)DHGFETDPDPFLLDEPAPR;Y(0.001)LGDAFGS(0.552)PQT(0.447)DHGFETDPDPFLLDEPAPR 118.74 6.9673e-16 11566100.0 1263.9 1547.26 1309.6999999999998 1784.8 1756.8 1537.06 1471.71 1470.8899999999999 810.97 1190.72 True False 1293.346410878711 1366.1060798983406 1131.8499336671384 1473.1181848453916 1597.8977501882325 1521.5985719388168 1360.6977298194818 1431.8772190759253 1376.1568590946913 1343.5605105949844 0.9626260973582526 1.016780464389633 0.8424257223561209 1.0964286113120678 1.189300919152958 1.1325121272468701 1.0127550780849524 1.0657333315354964 1.0242611689184522 1.0 10.391845582841917 -5.790414153814704 24.998862932841966 1.08180318093718 0.9482276684884383 0.44897526011373634 0.06743194272252019 188.5845404877547 162706.29696156952 0.01986447130854562 0.02946929357716316 1.6202642368802979e-06 5.790414153814704 -0.13357551244874166 YLGPS(ph)NSQVDFLLR ddPTM_A459_Selumetinib_30min_R1 1 YLGPSNSQVDFLLR 14 0 H7BYZ6 H7BYZ6 GPR75-ASB3 1 YLGPS(0.5)NS(0.5)QVDFLLR 81.525 0.031732 251360000.0 9131.9 10508.0 8917.5 8202.3 4381.2 10046.0 8092.2 6327.1 4265.2 4943.3 True False 9344.655502415779 9277.718474963336 7706.552480321224 6769.92228124012 3984.9212335636826 9944.946361038188 7481.798838932404 6159.284754682738 7237.732882117318 5577.8207068195625 1.6753237498277425 1.6633231798971595 1.3816422013886227 1.2137217449393936 0.7144226110910364 1.7829447886123848 1.341348033970507 1.1042457401243222 1.2975915258925965 1.0 12.445485845858807 -5.401990572413332 2.7577171486683434 1.2229692227326103 1.6791881809618499 0.33663022798066233 0.25628228187744667 0.33398551960346556 4.835956594464451 0.07226590542876113 0.1830508595581048 3.9628663668125426e-06 5.401990572413332 0.4562189582292395 YLGPS(ph)NSQVDFLLR ddPTM_A459_Selumetinib_30min_R2 3 YLGPSNSQVDFLLR 14 0 H7BYZ6 H7BYZ6 GPR75-ASB3 1 YLGPS(0.5)NS(0.5)QVDFLLR;YLGPS(0.5)NS(0.5)QVDFLLR;YLGPS(0.921)NS(0.079)QVDFLLR 86.898 0.022745 119517000.0 141654.0 195118.0 203241.0 98617.0 130323.0 288440.0 133507.0 112425.0 121533.0 164268.0 True False 133781.4377658908 210082.92319674563 190164.6953320692 85185.19447618605 113950.65963759774 328169.9918023776 139715.34003910157 112752.13813703922 145842.99591574277 159525.1560204795 0.8386228297981806 1.3169266116860943 1.192067132707623 0.5339922342106981 0.7143115385699356 2.0571676592514843 0.875820112165665 0.7067984821313344 0.9142319591088176 1.0 17.2834244194571 -7.487865493229423 24.999496351767554 0.8445698164054448 1.1103977962274663 0.07684269189656079 0.3945476942241958 1611.1588485850132 1150372.0782997652 0.17256206536159052 0.11627849065741565 3.251879968333401e-08 7.487865493229423 0.26582797982202144 YLGPSNS(ph)QVDFLLR ddPTM_A459_Selumetinib_30min_R2 1 YLGPSNSQVDFLLR 14 0 H7BYZ6 H7BYZ6 GPR75-ASB3 1 YLGPS(0.073)NS(0.927)QVDFLLR 89.663 0.019233 13024000.0 22657.0 30830.0 30088.0 11237.0 19218.0 47109.0 20481.0 23164.0 18552.0 27485.0 True False 21397.814643157213 33194.56186592554 28152.170837337442 9706.50121509379 16803.66302890014 53597.83713707598 21433.40708233157 23231.40340499335 22262.91838619022 26691.436635393853 0.8016733956831272 1.2436408845040696 1.0547266983751111 0.36365600502082385 0.6295525886612581 2.0080536641479694 0.8030068735195042 0.8703691645502375 0.8340846800531054 1.0 14.704089338494256 YLGS(ph)PITTVPK ddPTM_A459_Selumetinib_30min_R1 2 YLGSPITTVPK 11 0 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;A0A3B3IT42 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 YLGS(0.855)PIT(0.141)T(0.004)VPK;YLGS(1)PITTVPK 147.24 0.00066992 29790000.0 7884.0 8758.7 9007.2 9293.8 8517.3 7730.0 8118.900000000001 8788.0 5382.799999999999 6823.2 True False 8067.681860406487 7733.227332190844 7784.071713008052 7670.812296232693 7746.911718851446 7652.243218278442 7506.484836436106 8554.91369255297 9134.218455842887 7699.024183596225 1.0478836886362477 1.00444253034917 1.0110465336104584 0.9963356541438536 1.0062199486731385 0.9939237799229861 0.9749917206948967 1.1111685700092133 1.1864124904691857 1.0 12.91045988700219 -7.77142424411142 24.95704795588587 1.1115929537379508 1.0044807701822118 0.46364803938459187 0.04585682071806229 153.21922263056842 382963.2352564618 0.023230791447849106 0.011373652609912336 1.6926834808790796e-08 7.77142424411142 -0.10711218355573893 YLGS(ph)PITTVPK ddPTM_A459_Selumetinib_30min_R2 2 YLGSPITTVPK 11 0 D6RJC2;P30307-4;P30307-3;P30307-2;P30307;A0A3B3IT42 D6RJC2 CDC25C M-phase inducer phosphatase 3 1 YLGS(0.991)PIT(0.009)TVPK;YLGS(0.993)PIT(0.007)TVPK 147.58 0.00066406 17855200.0 157487.0 155996.0 152849.0 169238.0 180866.0 130370.0 138568.0 144384.0 122242.0 179933.0 True False 148734.5030104116 167960.39159380214 143014.86174940816 146187.49244816575 158143.99611744497 148327.2841189708 145011.68656728283 144804.13353594206 146693.8157268576 174737.86676792163 0.8511864415052838 0.9612134719309524 0.8184537467162374 0.8366102617146225 0.9050356344768943 0.8488559856117044 0.8298812916142574 0.8286934950869229 0.8395078779443338 1.0 17.414832757439726 -3.8851664036838813 13.613149047875456 0.8663071283831907 0.8709165633710828 0.0 0.05962025624905249 0.0 0.0 0.012980627351929917 0.0 0.00013026675544863627 3.8851664036838813 0.004609434987892125 YLHDESGLNR ddPTM_A459_Selumetinib_30min_R1 1 YLHDESGLNR 10 0 B5MCX3;Q15019;Q15019-3;Q15019-2;C9J2Q4;C9IY94;C9J938;H7C310;C9JB25 B5MCX3 SEPT2 Septin-2 0 135.55 0.0051128 0.0 1218.5 1814.5 1105.7 1207.2 1077.3 1158.8 1182.3 986.18 653.33 1186.7 False True 1246.8886792117337 1602.057496461836 955.5520131753491 996.385181950559 979.8584052127627 1147.1435241062177 1093.1181591248092 960.0233028359004 1108.653292664753 1339.0245044368687 0.9311918303811153 1.1964362796598609 0.7136180181984121 0.7441127318051525 0.7317703312866896 0.8567009194418386 0.8163541111478939 0.7169572324142354 0.8279559403067093 1.0 10.386966647195909 -5.268797564072733 24.99897561213099 0.7888679672000577 1.0638140592676322 0.5157194238864986 0.1013585829670787 347.9580355481864 1182168.4069424092 0.024704814056299845 0.05309058256237884 5.385207425141049e-06 5.268797564072733 0.2749460920675745 YLHDESGLNR ddPTM_A459_Selumetinib_30min_R2 1 YLHDESGLNR 10 0 B5MCX3;Q15019;Q15019-3;Q15019-2;C9J2Q4;C9IY94;C9J938;H7C310;C9JB25 B5MCX3 SEPT2 Septin-2 0 114.86 0.0095932 1808600.0 24344.0 21835.0 26060.0 24314.0 30472.0 19019.0 20620.0 21033.0 20344.0 22665.0 False True 22991.05793675327 23509.674289409144 24383.327971982642 21002.391256010527 26643.834936863615 21638.694612707735 21578.87085775486 21094.2025477994 24413.3684588537 22010.602559257844 1.0445446859010699 1.068106801079863 1.1077992029676085 0.9541942888417994 1.210500024482837 0.9831032364721118 0.9803852847580771 0.9583655191178309 1.1091640218902246 1.0 14.42591102034248 YLHDESGLNRR ddPTM_A459_Selumetinib_30min_R1 4 YLHDESGLNRR 11 1 B5MCX3;Q15019;Q15019-3;Q15019-2;C9J2Q4;C9IY94;C9J938;H7C310;C9JB25 B5MCX3 SEPT2 Septin-2 0 ;;; 128.91 0.0018131 32338300.0 7742.7 8048.7 8685.8 10298.7 8405.2 7516.91 6863.700000000001 5616.95 4053.7 5032.599999999999 False True 7923.089845328426 7106.354462260887 7506.316067684224 8500.225375541931 7644.951144058585 7441.2967102081975 6345.965583003431 5467.970239575037 6878.832829466133 5678.583231675219 1.3952582047460917 1.2514308890678116 1.3218642329329409 1.496891923345871 1.3462779063296875 1.3104143069877954 1.1175262075240076 0.962910996720911 1.2113642697171196 1.0 12.471315316576417 -7.260328664858791 2.943080576181981 1.0607471137352722 1.3592193176969827 0.7344509937895184 0.0836275973130091 0.1409733295299056 2.4716327641565536 0.03754917418019748 0.025592289086037282 5.491251502973448e-08 7.260328664858791 0.2984722039617105 YLHDESGLNRR ddPTM_A459_Selumetinib_30min_R2 2 YLHDESGLNRR 11 1 B5MCX3;Q15019;Q15019-3;Q15019-2;C9J2Q4;C9IY94;C9J938;H7C310;C9JB25 B5MCX3 SEPT2 Septin-2 0 ; 102.06 0.0098889 14419800.0 17315.3 21525.1 28710.0 20902.6 23122.4 16550.0 14390.9 13147.0 14390.8 24424.7 False True 16352.984944637858 23176.005955894692 26862.82985708451 18055.62982100376 20217.557395121275 18829.6122740582 15060.105365027364 13185.255593396987 17269.362112547755 23719.49544800816 0.6894322427929678 0.9770868021495327 1.1325211329206546 0.7612147509874615 0.8523603480283574 0.7938453967257306 0.6349251988954947 0.5558826334353674 0.7280661660953646 1.0 14.533785701305272 -6.641314989112168 1.5133116561257225 0.6981959479983203 0.9171441567101741 0.15988488717619642 0.15578741294654203 0.5463617157388773 2.59176220895035 0.06632947714918665 0.0664398465318159 2.2839416841877918e-07 6.641314989112168 0.21894820871185383 YLLGDAPVS(ph)PSSQK ddPTM_A459_Selumetinib_30min_R1 4 YLLGDAPVSPSSQK 14 0 Q9NYB0;A0A590UJT3;H3BMI8 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 Y(0.048)LLGDAPVS(0.945)PS(0.007)SQK;Y(0.001)LLGDAPVS(0.771)PS(0.224)S(0.004)QK;YLLGDAPVS(0.794)PS(0.205)S(0.001)QK;YLLGDAPVS(0.808)PS(0.186)S(0.006)QK 237.05 2.3741e-19 729900000.0 27121.4 31834.6 34195.3 35586.5 30861.1 27213.6 30586.1 27495.6 16541.5 24276.7 True False 27753.27585094222 28107.390232495985 29551.766081337642 29371.985816338285 28069.718953969732 26939.855891971823 28278.965851989626 26766.327369704068 28069.717356640624 27392.85092008301 1.0131576275835885 1.0260848830411118 1.0788130876758004 1.0722500517390205 1.0247096600445658 0.9834630199889464 1.0323484012121193 0.9771282093927797 1.0247096017326687 1.0 14.741511802373571 -6.518970403625353 14.027420321659305 1.003920114162492 1.048299718949459 0.433856861470688 0.023717475680722473 0.5800540435843202 2072.3214562281114 0.007897534653513052 0.008211948704803112 3.0271197137443286e-07 6.518970403625353 0.0443796047869669 YLLGDAPVS(ph)PSSQK ddPTM_A459_Selumetinib_30min_R2 3 YLLGDAPVSPSSQK 14 0 Q9NYB0;A0A590UJT3;H3BMI8 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 Y(0.001)LLGDAPVS(0.772)PS(0.226)SQK;Y(0.257)LLGDAPVS(0.528)PS(0.059)S(0.156)QK;Y(0.077)LLGDAPVS(0.877)PS(0.034)S(0.011)QK 205.33 1.3341e-05 257152100.0 725252.0 701000.0 855916.0 860601.0 874816.0 640731.0 647229.0 670716.0 571571.0 714506.0 True False 684945.3972537866 754764.4459297364 800847.2964108784 743385.6591804672 764913.7931257315 728985.879273086 677326.4309599326 672667.6725169889 685901.1710280883 693876.3552704647 0.9871288912659418 1.087750634816686 1.1541642690774754 1.0713517668298473 1.1023776603939435 1.0505991070828982 0.9761485973908405 0.9694344927703887 0.9885063323143967 1.0 19.40431908028001 -7.1202681420776255 3.3521580681819225 0.9807964971797822 1.0842534022065524 0.5732987916137259 0.039403834474558974 0.18392303215231562 3.8400008027740262 0.016599692158471947 0.012592535797326878 7.581093586581114e-08 7.1202681420776255 0.10345690502677019 YLLSQS(ph)SPAPLTAAEEELR ddPTM_A459_Selumetinib_30min_R1 4 YLLSQSSPAPLTAAEEELR 19 0 F8VS81;Q12792;Q12792-3;Q12792-4 F8VS81 TWF1 Twinfilin-1 1 YLLS(0.001)QS(0.911)S(0.088)PAPLTAAEEELR;YLLSQS(0.5)S(0.5)PAPLTAAEEELR;YLLS(0.01)QS(0.948)S(0.042)PAPLTAAEEELR;YLLS(0.001)QS(0.61)S(0.389)PAPLT(0.001)AAEEELR 284.84 3.7413999999999995e-72 29341600.0 5141.83 6475.53 6797.82 7718.959999999999 6700.51 5962.099999999999 6338.040000000001 6059.450000000001 3464.8700000000003 5064.6900000000005 True False 5261.624634740472 5717.371937207773 5874.71338175242 6370.988538824627 6094.450053571123 5902.126687153673 5859.956540014723 5898.733702132464 5879.631325907768 5714.792295758291 0.9207026891678679 1.0004513972365008 1.027983709243961 1.114824163172717 1.066434218107039 1.0327806124352807 1.0254014908580626 1.0321868926908682 1.0288442731806413 1.0 12.480485349274215 -4.829515914874965 2.045693086382276 1.0448289526680294 0.8936369633911927 0.6124024676224278 0.029219027027347372 0.44470604260285024 2.2622714853492707 0.008433260056555003 0.12277660592224345 1.4807579913726945e-05 4.829515914874965 -0.15119198927683675 YLLSQS(ph)SPAPLTAAEEELR ddPTM_A459_Selumetinib_30min_R2 3 YLLSQSSPAPLTAAEEELR 19 0 F8VS81;Q12792;Q12792-3;Q12792-4 F8VS81 TWF1 Twinfilin-1 1 YLLS(0.093)QS(0.873)S(0.035)PAPLTAAEEELR;YLLS(0.001)QS(0.998)S(0.001)PAPLTAAEEELR;YLLS(0.017)QS(0.889)S(0.094)PAPLTAAEEELR 232.73 6.7947e-24 11345100.0 80705.4 81759.0 92127.3 100032.7 105954.8 70969.0 81955.8 79809.4 76017.2 99563.1 True False 76220.11695731374 88029.65240337997 86199.92981862002 86408.07369396725 92643.81077606973 80744.33555756115 85766.9070923369 80041.63214084256 91222.76409803236 96688.45460699961 0.7883062902092957 0.9104463688160674 0.8915224694508636 0.8936751967458985 0.9581682854755538 0.8350980050902146 0.8870439334349226 0.827830297486708 0.9434711152310468 1.0 16.561056009937737 -8.51220381002449 5.905583510832835 0.9999461613407216 0.8786011853707688 0.44954679356659477 0.04521676663017034 0.12013640212198208 19.509568785764536 0.042532684420570566 0.011027364637626312 3.0746535721757935e-09 8.51220381002449 -0.12134497596995275 YLLSQSS(ph)PAPLTAAEEELR ddPTM_A459_Selumetinib_30min_R1 1 YLLSQSSPAPLTAAEEELR 19 0 F8VS81;Q12792;Q12792-3;Q12792-4 F8VS81 TWF1 Twinfilin-1 1 YLLSQS(0.091)S(0.909)PAPLTAAEEELR 255.22 2.1301999999999997e-38 18032000.0 1640.0 1912.4 2063.0 1662.2 1693.1 1731.4 1837.2 1764.5 815.39 1198.7 True False 1678.208809115504 1688.49531894936 1782.8559312478476 1371.9279733583667 1539.9594039410827 1713.98368798542 1698.6185248617953 1717.6997280962344 1383.6572762706644 1352.5648213267662 1.2407603559209126 1.2483655439841106 1.318129751074701 1.0143158773067946 1.1385475798716223 1.26721001534265 1.2558499955629305 1.2699574179456314 1.022987774377718 1.0 10.401482021165737 -8.274425553824738 21.834826598081065 1.0114934265077602 1.2167276029814287 0.5104454313267788 0.08131434254302418 141.93060135146024 238627.59783529275 0.08104896739077136 0.02168284954243914 5.3158711564444456e-09 8.274425553824738 0.20523417647366848 YLLSQSS(ph)PAPLTAAEEELR ddPTM_A459_Selumetinib_30min_R2 2 YLLSQSSPAPLTAAEEELR 19 0 F8VS81;Q12792;Q12792-3;Q12792-4 F8VS81 TWF1 Twinfilin-1 1 YLLSQS(0.006)S(0.993)PAPLTAAEEELR;YLLSQS(0.035)S(0.965)PAPLTAAEEELR 203.89 8.611499999999999e-16 9663500.0 66299.0 57816.0 76522.0 79061.0 75302.0 60965.0 64604.0 67672.0 55883.0 71291.0 True False 62614.36699592534 62250.30129225915 71598.65783085416 68292.75541216797 65841.8895515786 69362.37536483133 67608.21401039745 67868.91431629736 67061.16150148053 69232.64359373697 0.9044052595095423 0.899146675050417 1.0341748359487928 0.9864242049302011 0.9510237676022368 1.001873852627319 0.9765366523793052 0.9803022215150112 0.9686349967365268 1.0 16.07916481692491 -5.239914573550612 24.98719298370417 0.9854668672155128 0.9017759407505035 0.7246310261635339 0.021080020406294742 411.7375818998063 477966.48268746695 0.005350493955064543 0.014126043628461326 5.75553138466248e-06 5.239914573550612 -0.08369092646500931 YLMDEGAHLHIYDPK ddPTM_A459_Selumetinib_30min_R1 2 YLMDEGAHLHIYDPK 15 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 0 ; 127.79 0.00057855 26684000.0 27325.0 28246.0 30723.0 31792.0 27519.0 25027.0 23741.0 26632.0 18657.1 23185.0 False True 27961.619334805582 24938.945188790854 26550.985349359005 26240.124009751627 25029.911308874074 24775.25110269786 21950.197256011234 25925.632847072222 31659.736039330164 26161.020591024524 1.0688275420110642 0.9532864018824653 1.0149063281754487 1.003023713025716 0.9567635643947883 0.9470292268030972 0.8390420847549822 0.9910023485844791 1.2101873445331934 1.0 14.675131203752757 -8.0278423118929 23.599479899200478 1.1035942132654113 0.9662032344506509 0.35161227639075265 0.07290191810537078 382.8822609511295 324531.7123934641 0.048176304310054534 0.018328352625039866 9.379024883909609e-09 8.0278423118929 -0.13739097881476037 YLMEEDEDAYKK ddPTM_A459_Selumetinib_30min_R1 1 YLMEEDEDAYKK 12 1 A0A2R8Y6J3;P46777 A0A2R8Y6J3 RPL5 60S ribosomal protein L5 0 97.452 0.021904 12528000.0 1754.0 1753.2 2066.6 2213.3 1737.9 1756.2 1544.6 2075.6 1284.6 1937.0 False True 1794.864787310118 1547.934528959432 1785.9670710212329 1826.7887037865903 1580.7072518511666 1738.5342225020172 1428.0895784354059 2020.5483455010167 2179.87237652816 2185.632817977764 0.8212105768849132 0.7082317378413286 0.8171395745574876 0.8358168347219499 0.7232263529579049 0.7954374624144689 0.653398670942694 0.9244683411052137 0.9973644056759116 1.0 11.093835336094122 -7.937209473881021 6.239578566552125 0.987088555913334 0.7674001016532159 0.7618509195248344 0.054487723694908764 0.09015707025007347 6.630491464161128 0.03004873967732149 0.01411246103532802 1.1555547473738108e-08 7.937209473881021 -0.21968845426011807 YLMEEDEDAYKK ddPTM_A459_Selumetinib_30min_R2 2 YLMEEDEDAYKK 12 1 A0A2R8Y6J3;P46777 A0A2R8Y6J3 RPL5 60S ribosomal protein L5 0 ; 146.5 0.0035247 15057000.0 107661.0 103877.0 103167.0 117754.0 97897.0 88279.0 97148.0 100762.0 76998.0 99583.0 False True 101677.63262113024 111844.03188280099 96529.34753973648 101715.70206301958 85598.30364971586 100438.63093302608 101665.57449510992 101055.20073795292 92399.75150387429 96707.78004229315 1.0513904111609595 1.1565153479263852 0.9981549312529082 1.0517840655481525 0.8851232404702208 1.0385786013193699 1.0512657249566537 1.0449541980361716 0.9554531337961141 1.0 16.561344337265353 -5.279017164616731 24.60679661580546 1.0052731196336717 1.1039528791363191 0.35485665882085893 0.054299685779059054 636.816521382309 891466.8984019546 0.014164081801881405 0.029592413927889007 5.259964770260561e-06 5.279017164616731 0.0986797595026474 YLMKLEGS(ph)GS(ph)Y(ph)NK ddPTM_A459_Selumetinib_30min_R1 1 YLMKLEGSGSYNK 13 1 A0A075B6I1 A0A075B6I1 IGLV4-60 3 Y(0.001)LMKLEGS(0.999)GS(1)Y(1)NK 75.509 0.027305 0.0 502.33 609.16 736.87 533.06 627.01 662.56 640.94 581.26 248.46 382.08 True False 514.0333116359704 537.8392640091989 636.8071013371796 439.9710777754845 570.2970562076065 655.8952479563474 592.5933797762455 565.8430966014266 421.6184731995847 431.1236897743648 1.1923105220800965 1.2475289035744832 1.4770867768144738 1.0205216929873424 1.3228154001606365 1.5213621137349707 1.3745321675234046 1.3124843519908853 0.9779524605113795 1.0 8.75195802898095 -8.26023619296488 24.265773633050657 0.988976170337393 1.312325772049771 0.4773564389561411 0.1337224883606198 60.59421433484356 1222164.790430148 0.10628291942651319 0.03501750108946154 5.492420848916067e-09 8.26023619296488 0.3233496017123779 YLPHSAGR ddPTM_A459_Selumetinib_30min_R1 2 YLPHSAGR 8 0 M0R0F0;M0R0R2;P46782 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 ; 152.47 0.0014 39701000.0 15413.5 16246.4 18246.3 20268.1 19462.3 14831.800000000001 15731.2 15281.1 8696.900000000001 12084.3 False True 15772.604560549893 14344.263935253552 15768.552679751634 16728.656814357288 17701.93840134814 14682.605558196929 14544.582918738228 14875.795587991724 14758.004103555777 13635.43761604993 1.1567362195977016 1.0519841268878147 1.1564390614930369 1.2268514796082823 1.2982303098590422 1.0767975309361837 1.0666751833192478 1.0909657619262472 1.082327133100921 1.0 13.735073382433628 -6.957929705695321 24.99986407223541 1.0681670696266699 1.1740514000898918 0.45600963858382315 0.06252035032017665 159.94054786828585 95042.63036795275 0.0242460582735782 0.02138299913907313 1.1017176176017731e-07 6.957929705695321 0.10588433046322199 YLPHSAGR ddPTM_A459_Selumetinib_30min_R2 4 YLPHSAGR 8 0 M0R0F0;M0R0R2;P46782 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 ;;; 161.9 0.0005451000000000001 45404500.0 132161.0 122767.0 133383.0 146144.0 155524.0 118607.0 111068.0 122259.0 105844.0 122069.0 False True 124816.02070240109 132182.83414187745 124801.28299643 126238.93508753846 135985.68471779933 134944.03764285325 116232.88207706685 122614.75344893313 127015.75752845623 118544.55079664853 1.0529039071269555 1.1150477457932593 1.0527795850398411 1.0649071107797177 1.1471272513493205 1.1383402841884855 0.9804995783943953 1.0343347933323956 1.0714601107758992 1.0 16.85506982161492 -7.261075999996822 24.999990874288425 1.0244348540570036 1.0951445152558095 0.47574621122826444 0.03780784641101241 32.69741962633381 2249636.377006871 0.01588305449057414 0.011497499953600549 5.481810267876916e-08 7.261075999996822 0.07070966119880584 YLQAHTQSVYNYHLS(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 YLQAHTQSVYNYHLSPR 17 0 P50548;P50548-2 P50548 ERF ETS domain-containing transcription factor ERF 1 YLQAHTQSVYNYHLS(1)PR 164.74 2.8824e-06 18201000.0 991.02 1293.4 1282.3 1949.6 1695.7 4119.8 4764.4 4271.4 1740.9 1406.2 True False 1014.1088378107612 1141.9681267146527 1108.1707031697122 1609.1389585245272 1542.3242344001499 4078.35855247911 4405.017472159552 4158.10859653741 2954.1801496947473 1586.699467547927 0.639131012867835 0.7197129324555969 0.69841247560401 1.0141422439696648 0.9720329942403306 2.5703409094740377 2.7762141238800764 2.620602503234793 1.861839756119736 1.0 10.631813181747008 -6.707392114076731 5.968789640818338 2.3047009223942103 0.7946730894367456 0.6533687447202459 0.4896471015984661 0.11027963132593803 8.323027589407095 0.15982501237994154 0.1577779535231987 1.961588405918346e-07 6.707392114076731 -1.5100278329574648 YLQDQLS(ph)PLTR ddPTM_A459_Selumetinib_30min_R1 1 YLQDQLSPLTR 11 0 H0YC17;E7EMV7;A0A0A0MRZ4;Q15025-7;Q15025-8;Q15025-5;Q15025-6;Q15025-4;Q15025-3;Q15025-2;Q15025 H0YC17 TNIP1 TNFAIP3-interacting protein 1 1 Y(0.001)LQDQLS(0.998)PLT(0.001)R 81.185 0.042366 6734300.0 1189.6 1863.0 1932.1 1976.4 1805.5 1674.9 1882.8 1521.3 721.45 1374.0 True False 1217.3153654413436 1644.879093914798 1669.7314322656157 1631.2588416228343 1642.1928437869153 1658.052026687524 1740.7788801490226 1480.9501821211695 1224.2479573768023 1550.366283893365 0.7851792044808626 1.060961600496166 1.0769915790947764 1.052176416998909 1.059228945345064 1.0694582589371928 1.1228178129477138 0.9552259988537198 0.7896507877495913 1.0 10.598393386308969 -7.99630709069037 24.014960976459218 0.8873630500223163 1.0384750969029515 0.24220944450964277 0.09852656421810878 75.61009546740608 491693.67378662067 0.05305480164283294 0.02527604419486986 1.0085394931431344e-08 7.99630709069037 0.15111204688063518 YLS(ph)EVASGDNK ddPTM_A459_Selumetinib_30min_R2 1 YLSEVASGDNK 11 0 P31946-2;P31946 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 Y(0.008)LS(0.992)EVASGDNK 144.57 0.00074592 2358800.0 29060.0 23029.0 30622.0 28834.0 30206.0 22459.0 29223.0 22772.0 19148.0 28797.0 True False 27444.961536397062 24795.250250094035 28651.813858712703 24906.759458575616 26411.252234933807 25552.52338749687 30581.927404275964 22838.262749892467 22978.135039821595 27965.55578640848 0.9813844482838981 0.8866353466911878 1.0245394040277844 0.890622723496185 0.9444207880813841 0.9137141268587136 1.0935569326013204 0.8166568518903555 0.8216584435267752 1.0 14.77136338222508 YLS(ph)FTPPEK ddPTM_A459_Selumetinib_30min_R1 2 YLSFTPPEK 9 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 YLS(0.969)FT(0.031)PPEK;YLS(0.965)FT(0.035)PPEK 175.65 0.00033454 689320000.0 16320.6 20947.1 12206.6 12512.2 13471.8 13762.2 17428.8 16359.2 9015.7 15538.2 True False 16700.838225640557 18494.603793957394 10549.01076605428 10327.179153082985 12253.278068639474 13623.764763077821 16114.131583992625 15925.300873829376 15298.984419325028 17532.67932488492 0.9525548215517925 1.0548646588035846 0.6016770495015895 0.5890245844184896 0.6988822325203795 0.777049788604814 0.9190912173429826 0.9083210032379865 0.8725981999574071 1.0 14.097758863573457 -7.2546237848976345 7.116130324801508 0.9176387627991269 0.7709877377991964 0.21067066276294744 0.13764184616930314 0.2632999046533726 91.6380561391007 0.06203528413338598 0.04537942809468042 5.5638602758368766e-08 7.2546237848976345 -0.14665102499993055 YLS(ph)FTPPEK ddPTM_A459_Selumetinib_30min_R2 4 YLSFTPPEK 9 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 Y(0.012)LS(0.976)FT(0.012)PPEK;Y(0.005)LS(0.829)FT(0.166)PPEK;Y(0.011)LS(0.679)FT(0.31)PPEK;Y(0.001)LS(0.969)FT(0.03)PPEK 138.25 0.0024831 479192000.0 591676.0 435837.0 520249.0 586790.0 611461.0 618580.0 629643.0 623776.0 545462.0 513499.0 True False 558793.0165866925 469264.296463165 486776.7457442815 506868.18973078835 534643.8026493038 703783.7800898447 658922.6471139358 625591.0848883243 654569.6414816793 498672.94963937084 1.1205601125763873 0.9410261711659446 0.976144276717451 1.016434097934015 1.0721331546777226 1.4113133279011936 1.3213522963105457 1.2545117703712179 1.3126231169247289 1.0 18.92773442101398 -6.60893545277712 6.117309039089766 1.2788051869799737 1.0102109845172726 0.5411986516261273 0.10829846879029692 0.1431596693967556 8.157855383755479 0.03433022393975426 0.03431378687982514 2.460733304622566e-07 6.60893545277712 -0.26859420246270105 YLS(ph)FTPPEKDGFPSGTPALNAK ddPTM_A459_Selumetinib_30min_R1 1 YLSFTPPEKDGFPSGTPALNAK 22 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 Y(0.013)LS(0.971)FT(0.016)PPEKDGFPSGTPALNAK 91.618 0.0001948 920070000.0 8790.3 11715.0 11593.0 12378.0 9787.9 8778.3 8723.1 9451.9 5299.8 6990.8 True False 8995.096887053673 10343.402353844253 10018.73427579074 10216.414663836991 8902.586173194104 8689.998272058685 8065.109543991898 9201.204907901845 8993.373517923035 7888.137276158467 1.1403321940454738 1.311260439788074 1.2701014098818875 1.2951618748719846 1.128604366470873 1.1016540366664012 1.0224352418876281 1.166461052308517 1.1401137179882879 1.0 12.94546894361799 -6.381232822931553 4.303584726028787 1.09458565409722 1.2590180184633002 0.6118207405813407 0.06321689148367393 0.16037650530011482 4.896177883699675 0.019976277074388562 0.022755629668605733 4.156877028120124e-07 6.381232822931553 0.1644323643660801 YLS(ph)FTPPEKDGFPSGTPALNAK ddPTM_A459_Selumetinib_30min_R2 1 YLSFTPPEKDGFPSGTPALNAK 22 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 Y(0.018)LS(0.674)FT(0.306)PPEKDGFPS(0.001)GT(0.001)PALNAK 66.075 0.0036098 214450000.0 308020.0 313560.0 294950.0 386490.0 339920.0 305010.0 229360.0 263890.0 199850.0 313880.0 True False 290901.48150175554 337609.043745689 275973.2381172784 333849.39526756253 297216.2106766433 347022.35889489343 240025.69446821796 264657.8762106585 239825.5842755555 304817.4688418208 0.9543464900717791 1.1075777416184922 0.9053721204557651 1.0952436437978799 0.975062918165225 1.1384595515914282 0.7874407440630469 0.8682503572260738 0.7867842521847342 1.0 18.21758605931953 -7.271135974483449 24.99926347981586 0.8496396981065356 1.027792902307005 0.46801341809125174 0.08780553327424802 558.5466832917613 1440010.6741052286 0.033547330088791856 0.022936029272672766 5.3562892968619464e-08 7.271135974483449 0.17815320420046932 YLSDSCS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 YLSDSCSPR 9 0 P83436 P83436 COG7 Conserved oligomeric Golgi complex subunit 7 1 YLSDSCS(1)PR;YLSDSCS(1)PR 95.483 0.022335 11766100.0 4569.9 5458.0 6364.200000000001 6538.200000000001 5117.4 5034.4 5502.9 4740.9 2685.6000000000004 3935.3999999999996 True False 4676.369778522527 4818.974822644641 5499.976596048261 5396.426107214337 4654.532073550351 4983.75850686947 5087.8118225897915 4615.155931386481 4557.267051536683 4440.546924042176 1.053106713770673 1.085221011077164 1.2385808978326702 1.2152615881608646 1.048188917529417 1.1223298823589087 1.1457624273809988 1.0393215093390704 1.026285079178548 1.0 12.116521663041453 -7.838695954213237 4.5425359314297475 1.0195036562781337 1.1321718099388713 0.41634713180989025 0.05879753260136484 0.23210224535736623 8.80315934392947 0.0366652069741636 0.01707554606969582 1.4497864812341568e-08 7.838695954213237 0.11266815366073768 YLSDSCS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 YLSDSCSPR 9 0 P83436 P83436 COG7 Conserved oligomeric Golgi complex subunit 7 1 YLSDS(0.001)CS(0.999)PR 89.561 0.029706 6924300.0 77858.0 52764.0 70179.0 67420.0 73302.0 50748.0 49347.0 54609.0 47228.0 63336.0 True False 73530.9640502685 56810.82913699949 65663.75954511773 58237.27969401294 64093.1474318055 57738.07635552297 51641.73327922543 54767.903148993384 56674.919660575215 61507.3251133093 1.1954830406753856 0.923643306424757 1.0675762508636397 0.9468348621359772 1.0420408839716664 0.9387187013767452 0.8396029771102971 0.8904289537563128 0.9214336594246004 1.0 15.908470615616558 -6.884659773333347 4.394777976302429 0.9019292576591754 1.0256342085389876 0.35319291926538543 0.07854407541880465 0.2357338133642754 7.938694885778591 0.026911736171106607 0.023667034501494197 1.3041880804075485e-07 6.884659773333347 0.12370495087981215 YLSEVASGDNK ddPTM_A459_Selumetinib_30min_R1 1 YLSEVASGDNK 11 0 P31946-2;P31946 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 135.55 0.042249 0.0 1441.3 1475.4 1632.9 1735.3 1523.0 1367.1 1190.7 1338.3 1071.1 926.89 False True 1474.8794857184007 1302.6594821051485 1411.1611488776598 1432.2624306153116 1385.2449189074891 1353.3482152274842 1100.8845403619298 1302.8039365889433 1817.5784699511992 1045.8653601731598 1.4102001480135173 1.24553267725539 1.3492761139388145 1.3694520204571814 1.3244964138387179 1.2939985076123142 1.0526063700777513 1.2456707968349225 1.7378704173262511 1.0 10.030481422372182 -6.819609194712906 4.526073791281186 1.2664402025506447 1.337076890156294 0.038068139035571935 0.1883507706716745 1.0020181475327867 41.51999265509005 0.06757912321728629 0.06060497612312681 1.5149238583254197e-07 6.819609194712906 0.07063668760564923 YLSEVASGDNK ddPTM_A459_Selumetinib_30min_R2 2 YLSEVASGDNK 11 0 P31946-2;P31946 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 ; 148.56 0.0089581 6727800.0 39197.0 33558.0 40867.0 38450.0 39144.0 32953.0 37026.0 35628.0 30271.0 36432.0 False True 37018.58765802324 36131.79069402298 38237.661712625304 33213.04367005039 34226.380768200004 37491.97663244954 38747.782365627114 35731.6715814671 36326.045842408574 35380.11349829612 1.04631059648257 1.0212457542218754 1.0807670731318257 0.9387489294416737 0.9673903609678448 1.0596906828536636 1.0951853607675164 1.0099366013392779 1.0267362721761197 1.0 15.110651055705755 -6.806180385363503 24.99993089483873 1.0424855363470447 1.0113413073961748 0.08401187136025978 0.044190522283551685 344.2053058944932 192329.56819782438 0.016570531485736225 0.01461391145602315 1.562498519943558e-07 6.806180385363503 -0.03114422895086988 YLSFT(ph)PPEKDGFPS(ph)GTPALNAK ddPTM_A459_Selumetinib_30min_R1 1 YLSFTPPEKDGFPSGTPALNAK 22 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 2 YLS(0.356)FT(0.643)PPEKDGFPS(0.95)GT(0.05)PALNAK 83.411 0.0026553 20008000.0 6277.7 6748.5 7874.2 8097.5 6434.5 6133.0 6108.5 6011.4 4013.1 4743.1 True False 6423.958195722198 5958.382482707463 6804.926889884541 6683.423633900476 5852.500611103244 6071.307588318461 5647.730927018434 5851.958144220861 6809.937594772811 5351.923086706424 1.2003083922634443 1.1133161643349128 1.271491906673176 1.2487891783238345 1.093532271724943 1.1344160762322812 1.055271317528229 1.0934309124801265 1.2724281504881734 1.0 12.385841667602495 -6.270839836112023 24.59877005650939 1.1115177212462566 1.2061803574420804 0.2952904647599096 0.07576696004851668 741.2565194286415 1939689.8464922626 0.023406309276866807 0.02688675268633884 5.359942909286954e-07 6.270839836112023 0.09466263619582382 YLSFT(ph)PPEKDGFPSGTPALNAK ddPTM_A459_Selumetinib_30min_R1 1 YLSFTPPEKDGFPSGTPALNAK 22 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 Y(0.005)LS(0.177)FT(0.818)PPEKDGFPSGTPALNAK 103.71 0.00011277 1067500000.0 5802.6 7239.9 7786.6 8097.8 6637.0 6222.8 5747.1 6000.2 3663.2 5000.6 True False 5937.789290105871 6392.249142261803 6729.222488732187 6683.671244532172 6036.68452185752 6160.204281850337 5313.591619983246 5841.055204603591 6216.1828504576915 5642.475719968826 1.052337588107278 1.132880221290012 1.1926010536327776 1.184528135562646 1.0698645100932525 1.0917555675160924 0.9417128019139449 1.0351936799536396 1.1016764907748748 1.0 12.462112590058652 -6.700429408860089 2.109352127055936 1.0250519859545448 1.141457242893175 0.45629548047402924 0.054886651608353924 0.29136735558559557 2.6625988669994896 0.022067418554833674 0.021150677164653936 1.9932904734671796e-07 6.700429408860089 0.11640525693863024 YLSFT(ph)PPEKDGFPSGTPALNAK ddPTM_A459_Selumetinib_30min_R2 2 YLSFTPPEKDGFPSGTPALNAK 22 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 Y(0.015)LS(0.059)FT(0.766)PPEKDGFPS(0.106)GT(0.054)PALNAK;Y(0.011)LS(0.375)FT(0.613)PPEKDGFPSGT(0.001)PALNAK 73.984 0.0028748000000000003 169692500.0 91117.0 107062.0 91474.0 103005.0 107352.0 102529.0 75785.0 80398.0 54197.0 108367.0 True False 86053.08191025081 115273.31114141173 85588.66242936067 88975.5413064639 93865.48202094321 116651.43908440547 79309.15266512851 80631.94486939469 65037.914390704565 105238.16313872015 0.8176984407910993 1.0953565484553707 0.8132854078471666 0.8454683990367676 0.8919338690586418 1.108451873401105 0.7536158965506344 0.7661854071237384 0.6180069325704075 1.0 16.68329844700245 YLSPGWGS(ph)ASEEEPSR ddPTM_A459_Selumetinib_30min_R1 3 YLSPGWGSASEEEPSR 16 0 Q9BRS8;H0YMC6;Q9BRS8-2 Q9BRS8 LARP6 La-related protein 6 1 YLS(0.028)PGWGS(0.972)ASEEEPSR;YLSPGWGS(0.995)AS(0.005)EEEPSR;YLSPGWGS(0.964)AS(0.036)EEEPSR 239.51 2.6575e-51 36740000.0 5394.0 6621.45 7042.3 7367.799999999999 6530.27 6156.8 6734.5 5681.01 3490.5599999999995 4593.35 True False 5519.66970510307 5846.2075557714115 6085.994340584935 6081.152040735033 5939.6082315128115 6094.868181927131 6226.511243022944 5530.331160278833 5923.225379584408 5182.9512155179 1.064966555845061 1.127968856482327 1.1742333831665825 1.1732991085325855 1.145989607953372 1.175945504499237 1.201344752074956 1.0670235798710332 1.1428286961008058 1.0 12.339558099094399 -9.050519794924272 0.9247777608081672 0.9999833490838146 1.1493840813275107 0.49470679058958367 0.04293526422593776 1.5955901562411974 2.0122265889885873 0.04395608742340341 0.013955463571483044 8.90184862906748e-10 9.050519794924272 0.1494007322436961 YLST(ph)MLMLGNILGTT(ph)MERK ddPTM_A459_Selumetinib_30min_R1 1 YLSTMLMLGNILGTTMERK 19 1 C9JG08;Q68DN1 C9JG08 C2orf16 Uncharacterized protein C2orf16 2 Y(0.064)LS(0.408)T(0.531)MLMLGNILGT(0.117)T(0.88)MERK 48.96100000000001 0.035707 9072200.0 1565.5 1491.4 1740.2 1527.0 1418.4 1759.3 2324.5 3201.8 1016.9 1335.7 True False 1601.9731040672705 1316.7861946669502 1503.8903982343695 1260.338115340046 1290.105970438859 1741.6030393165931 2149.161093534313 3116.8778630878573 1725.6050285625754 1507.1501058197728 1.0629154308395323 0.8736927991327849 0.9978371712460384 0.8362392773442562 0.8559903658283203 1.1555604399266497 1.425976805651575 2.0680606736198435 1.1449456971135468 1.0 10.557607395119627 -7.104478557486712 2.9071127637680783 1.5002163136376234 0.9245584816427815 0.3956190825730187 0.27297328179490576 0.2303306462359316 3.753306591584514 0.10982088709521515 0.08301940636922153 7.861790063722257e-08 7.104478557486712 -0.5756578319948419 YLSVPPS(ph)PNISTSESR ddPTM_A459_Selumetinib_30min_R1 1 YLSVPPSPNISTSESR 16 0 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 YLSVPPS(0.973)PNIS(0.016)T(0.002)S(0.004)ES(0.004)R 131.61 0.0006886 7286700.0 1059.1 1535.2 1326.3 1152.5 1468.8 1264.5 1413.5 1488.1 908.4 1138.0 True False 1083.7749693501414 1355.458070304882 1146.1957448444116 951.2375101043897 1335.947299337702 1251.7802780741386 1306.8785569846211 1448.6307539699678 1541.4884530890386 1284.073385058697 0.8440132643202478 1.055592371960051 0.8926247971349528 0.7407968432122803 1.0403979358832622 0.9748510425024638 1.017760022278541 1.128152620267687 1.2004675675281398 1.0 10.32651193979745 -7.1887163963461775 1.252990454907717 1.1189955091057304 0.906747312973293 0.44214570712076773 0.09571313365227112 0.4385589391479725 1.3587432234426182 0.0605783584162961 0.037080323259022725 6.475653518326125e-08 7.1887163963461775 -0.2122481961324374 YLSVPPS(ph)PNISTSESR ddPTM_A459_Selumetinib_30min_R2 1 YLSVPPSPNISTSESR 16 0 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 YLSVPPS(0.808)PNIS(0.126)T(0.04)S(0.026)ESR 125.61 0.001191 7724400.0 153820.0 114620.0 130750.0 140980.0 150300.0 126130.0 119890.0 141970.0 129630.0 124760.0 True False 145271.30019024774 123410.9854386115 122337.68734983612 121778.28079593474 131417.9703009518 143503.26260585868 125465.12255752823 142383.1091956012 155559.62216482486 121157.85463459106 1.1990250291933793 1.018596654841866 1.0097379795870718 1.0051208084132464 1.0846838671525258 1.1844321859169658 1.035550876465482 1.1751867811214134 1.2839417026158861 1.0 16.886528411830646 -6.552178618491192 7.675421983335549 1.1401083898137836 1.0509403845699534 0.1412852813840596 0.09012300668935422 0.3561581589617852 74.35467760771193 0.02959011155455648 0.029838756679961095 2.8042800444551354e-07 6.552178618491192 -0.08916800524383017 YLSVPPSPNIS(ph)TSESRSPPEGDTTLFLSR ddPTM_A459_Selumetinib_30min_R2 2 YLSVPPSPNISTSESRSPPEGDTTLFLSR 29 1 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 YLS(0.001)VPPS(0.19)PNIS(0.223)T(0.223)S(0.223)ES(0.068)RS(0.068)PPEGDT(0.001)T(0.001)LFLS(0.004)R;YLSVPPS(0.091)PNIS(0.485)T(0.123)S(0.1)ES(0.087)RS(0.087)PPEGDT(0.017)T(0.007)LFLS(0.004)R 59.661 0.0021609000000000003 5589000.0 25360.0 35365.0 35139.0 33889.0 33129.0 18779.3 19610.0 18374.5 14425.2 30112.0 True False 23950.59272412352 38077.38178360223 32878.19499645043 29273.259738214227 28967.038842982252 21365.97811348769 20521.903856477828 18427.966752937773 17310.643073764062 29242.588319628147 0.8190312178367417 1.3021207756101403 1.1243257483600384 1.001048861278996 0.9905771174003452 0.7306459291480182 0.7017813755803265 0.6301756380630846 0.591966856167272 1.0 14.83578339229767 -6.658183704935333 1.9679567213907312 0.6956886097513307 1.08709441403651 0.5122335177585704 0.15324838077807504 0.23674518470882222 1.880996853963419 0.057558609292746116 0.05675759118979862 2.196930382909487e-07 6.658183704935333 0.39140580428517924 YLSVPPSPNISTSES(ph)RSPPEGDTTLFLSR ddPTM_A459_Selumetinib_30min_R1 1 YLSVPPSPNISTSESRSPPEGDTTLFLSR 29 1 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 YLS(0.001)VPPS(0.042)PNIS(0.129)T(0.129)S(0.129)ES(0.358)RS(0.164)PPEGDT(0.03)T(0.014)LFLS(0.006)R 46.25899999999999 0.023642 38687000.0 3501.3 3855.0 4218.9 5428.7 4426.6 2923.6 3698.6 2613.3 1891.8 2404.3 True False 3582.8734776561696 3403.6548078591213 3645.9965527588674 4480.679454319913 4026.2148115797045 2894.191238416409 3419.611624240057 2543.9867948052674 3210.2464283948075 2712.915324865226 1.3206727997801266 1.2546115157605262 1.343940416916623 1.6516105066944937 1.4840915876280516 1.0668195987872156 1.2604933124515927 0.9377317351147513 1.1833198032283916 1.0 11.405628303788157 -6.766150106400506 24.998622493166486 1.0964573525996288 1.4119412862186478 0.6024250701548169 0.13045416726849154 91.42264919145036 485153.25961750664 0.04826664074953194 0.043944806402974324 1.7133650100780158e-07 6.766150106400506 0.31548393361901894 YLSVPPSPNISTSESRS(ph)PPEGDTTLFLSR ddPTM_A459_Selumetinib_30min_R1 1 YLSVPPSPNISTSESRSPPEGDTTLFLSR 29 1 Q9BTC0;Q9BTC0-1 Q9BTC0 DIDO1 Death-inducer obliterator 1 1 YLSVPPS(0.006)PNIS(0.032)T(0.032)S(0.12)ES(0.12)RS(0.659)PPEGDT(0.012)T(0.015)LFLS(0.004)R 56.15600000000001 0.0035757 45113000.0 2254.7 2567.7 2894.5 3427.6 2589.7 2247.4 2107.0 2006.9 1315.7 1522.0 True False 2307.230123117517 2267.072490308656 2501.442798350411 2829.034004020655 2355.4620922486693 2224.7931964759327 1948.067293644567 1953.670492670069 2232.64680507403 1717.363525535446 1.3434721821043454 1.3200888784462916 1.4565598728262859 1.647312267877943 1.3715570740995415 1.2954701572471552 1.1343360125441067 1.137598687535271 1.3000432185014104 1.0 10.745979740994414 -6.942625977400461 2.375908163022255 1.155231028755362 1.4383354481653754 0.6079261023559348 0.10779847374653233 0.22324309250081523 2.5531774957751923 0.04662405428574887 0.038396723264794944 1.1412322151676407e-07 6.942625977400461 0.2831044194100134 YMACCLLYR ddPTM_A459_Selumetinib_30min_R2 1 YMACCLLYR 9 0 Q9BQE3;F5H5D3;A0A1W2PQM2;P68363;P68363-2;P68366-2;P68366;A6NHL2-2;A6NHL2 Q9BQE3;P68363;P68366-2;A6NHL2-2 TUBA1C;TUBA1B;TUBA4A;TUBAL3 Tubulin alpha-1C chain;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha chain-like 3 0 153.88 0.013201 9313300.0 25427.0 17040.0 17062.0 27104.0 23626.0 23644.0 27734.0 25274.0 16683.0 21511.0 False True 24013.86913234579 18346.913207764228 15964.24949570101 23412.388442992073 20657.89066088016 26900.746381137884 29023.685953878416 25347.543155664047 20020.066161966977 20889.921537709914 1.1495432900021483 0.8782662574698944 0.7642082076221677 1.1207504250663973 0.9888926879686504 1.287738028722482 1.3893630907845036 1.2133862307671839 0.9583600458157443 1.0 14.350519453219698 -5.912505752411347 7.65192534596489 1.1599165893762633 0.9257211924154586 0.26144638383229024 0.15678234572484076 0.3018454061962947 22.802143069858158 0.04663445496792848 0.06944690374390577 1.2231909172693319e-06 5.912505752411347 -0.2341953969608047 YMEDS(ph)TYYK ddPTM_A459_Selumetinib_30min_R2 1 YMEDSTYYK 9 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-4;Q05397-3;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 YMEDS(0.397)T(0.397)Y(0.206)Y(0.001)K 141.39 0.0022108 9537500.0 51097.0 45984.0 46518.0 51255.0 45649.0 44774.0 53724.0 53134.0 36068.0 56739.0 True False 48257.23329749764 49510.824938135556 43525.08252496888 44273.980580193296 39914.16451276214 50941.21208209553 56222.2724520864 53288.61114319277 43282.60782412187 55100.79764437374 0.8757991782433863 0.8985500583436841 0.7899174673637989 0.8035088868575397 0.7243845138208759 0.9245095218199089 1.0203531501476761 0.9671114288966013 0.7855169012882954 1.0 15.749785583087318 -6.930057918516809 10.1497514973099 0.9450468678135473 0.8206248069938065 0.404752651713535 0.07365053908060613 0.4270820103692765 59.017642872047105 0.026913170000222846 0.02373497089482005 1.1747408783311896e-07 6.930057918516809 -0.12442206081974083 YMEDST(ph)YYK ddPTM_A459_Selumetinib_30min_R2 1 YMEDSTYYK 9 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-4;Q05397-3;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 YMEDS(0.132)T(0.637)Y(0.229)Y(0.002)K 133.86 0.0070648 8575600.0 53964.0 50521.0 47662.0 46300.0 53701.0 46315.0 50773.0 51083.0 39154.0 53611.0 True False 50964.89691500795 54395.798249381245 44595.47881046194 39993.86012804505 46954.600286968845 52694.47084429034 53134.04510479085 51231.643072754094 46985.8940541662 52063.11113189375 0.978906096984799 1.0448049889215802 0.8565657687548919 0.7681803729847582 0.9018784945067287 1.0121268149111786 1.0205699188852555 0.9840296125017719 0.9024795682135628 1.0 15.667973904899716 -6.75129000140862 24.860148240388433 0.9851385788085023 0.906697667228654 0.19742188005600436 0.07419536029845843 356.5881448038708 873434.5207062325 0.027735714818082444 0.027430927909786653 1.7730051561450562e-07 6.75129000140862 -0.07844091157984834 YMEDSTY(ph)YK ddPTM_A459_Selumetinib_30min_R1 1 YMEDSTYYK 9 0 E7ESA6;Q05397-5;Q05397;Q05397-7;Q05397-2;H0YBP1;H0YBZ1;H0YB16;Q05397-4;Q05397-3;E9PEI4 E7ESA6;E9PEI4 PTK2 Focal adhesion kinase 1 1 YMEDS(0.001)T(0.037)Y(0.874)Y(0.088)K 204.27 0.036797 61855000.0 1369.1 1605.1 1930.2 1914.1 1620.3 1642.0 1339.2 1630.7 851.38 1203.5 True False 1400.9973661951456 1417.1741458092542 1668.089441829663 1579.838367106996 1473.7441510872002 1625.4829708167147 1238.1830658038944 1587.4485387398872 1444.7296776650662 1357.9809480827255 1.0316767464029248 1.0435891223732565 1.2283599738161026 1.163372998227627 1.0852465589947458 1.1969851072739008 0.9117823542016782 1.1689770323958795 1.0638806676226331 1.0 10.407247523965365 -7.212004067544991 24.99957701576607 1.0502404028859746 1.1258299747635094 0.20479094193027692 0.08380904584247392 718.537240246995 363366.3268221462 0.03231923675887977 0.025034299816599815 6.137562567775063e-08 7.212004067544991 0.07558957187753479 YMEDVTQIVVEPEPTAEEKPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 YMEDVTQIVVEPEPTAEEKPSPR 23 1 O15297-2;O15297 O15297-2 PPM1D Protein phosphatase 1D 1 YMEDVTQIVVEPEPT(0.256)AEEKPS(0.744)PR 89.634 0.0038467 0.0 6120.7 6188.3 6519.9 6754.0 6417.0 5528.1 5910.3 5792.3 4437.7 5537.9 True False 5780.535997103426 6662.922711479302 6100.416732330377 5834.093548700136 5610.839091292136 6289.545595904602 6185.140661037272 5809.154634033116 5325.363999697945 5378.00643780781 1.0748473554188782 1.2389205532813106 1.1343267812853415 1.084805980834459 1.0432934873129742 1.1694938763346583 1.150080560996589 1.0801687765180608 0.9902115330804023 1.0 12.392855766869497 -8.10311732965834 3.158628013329691 0.9946394855854594 1.1288823224520361 0.507899253824911 0.05165721455620836 0.22504142506402292 4.047243211699217 0.043263444162670535 0.014358321748453461 7.886470267540994e-09 8.10311732965834 0.13424283686657668 YMLTHQELAS(ph)DGEIETK ddPTM_A459_Selumetinib_30min_R1 6 YMLTHQELASDGEIETK 17 0 Q02241;H7BYN4;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 YMLTHQELAS(1)DGEIETK;YMLTHQELAS(0.998)DGEIET(0.002)K;YMLTHQELAS(0.991)DGEIET(0.009)K;YMLT(0.001)HQELAS(0.996)DGEIET(0.003)K;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK 221.13 3.9375e-40 169675300.0 20064.0 29085.559999999998 30209.660000000003 32833.21 24322.640000000003 25072.48 25375.809999999998 22812.77 12139.08 19564.64 True False 20531.452162252135 25680.20911369001 26107.354101784225 27099.506229183997 22122.66150651087 24820.273615190406 23461.692221518162 22207.701233279662 20599.132156675576 22075.9521197318 0.9300369945947125 1.1632662081531095 1.1826150899488996 1.2275577552536034 1.0021158492519706 1.1243127127914765 1.062771476141578 1.0059679923580784 0.9331027737763473 1.0 14.43018804115109 -7.691088609180825 1.7170408002532955 0.9645371934108627 1.113864983147507 0.3132049973069033 0.08315451620400965 0.446929217699361 2.54767458434994 0.06132888972074502 0.02589463506577563 2.03662650204267e-08 7.691088609180825 0.14932778973664418 YMLTHQELAS(ph)DGEIETK ddPTM_A459_Selumetinib_30min_R2 10 YMLTHQELASDGEIETK 17 0 Q02241;H7BYN4;A0A2U3TZL8;Q02241-2;Q02241-3 Q02241;Q02241-2 KIF23 Kinesin-like protein KIF23;Kinesin-like protein 1 YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(0.999)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK;YMLTHQELAS(1)DGEIETK 238.05 1.8785e-22 81829100.0 464468.0 398814.0 433616.0 453477.0 430653.0 356825.0 439888.0 422343.0 335021.0 403903.0 True False 438654.72797272145 429401.7514108736 405717.61864540336 391712.6503085423 376550.5200533318 405974.4048151555 460343.6636215353 423571.9482073525 402034.56126885675 392241.270923976 1.1183288462721235 1.094738833573941 1.034357291596782 0.9986523075091297 0.9599971955177421 1.0350119554192483 1.1736237304583863 1.0798760344865623 1.0249675163498513 1.0 18.581381815741544 -5.134662927856892 3.7933094973431714 1.0417284498894184 1.1136465099598187 0.20353530133444298 0.05438859155646128 0.44066613520733483 10.925595794162192 0.01592964924503171 0.050622593460329025 7.333935263674224e-06 5.134662927856892 0.07191806007040036 YMNSDTTS(ph)PELR ddPTM_A459_Selumetinib_30min_R1 2 YMNSDTTSPELR 12 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 YMNSDTT(0.004)S(0.996)PELR;YMNSDT(0.001)T(0.028)S(0.971)PELR 169.58 0.00034175 51940000.0 6294.9 7093.4 7018.4 7726.9 6659.6 5679.5 6996.4 6435.2 3442.8 5339.4 True False 6441.558922256819 6262.901430367805 6065.339829311633 6377.5419668768845 6057.240355847879 5622.369386573405 6468.655915166044 6264.517591524454 5842.180147836793 6024.764000160287 1.0691802902296992 1.0395264329359926 1.0067348412568968 1.0585546532125096 1.0053904776497018 0.9332098960928301 1.0736778926102246 1.039794685959116 0.9696944390985878 1.0 12.556689014391937 -1.5228787456229735 0.5948768027563157 1.0090524530877678 4.701919365195122 0.19766533462610647 0.03843341938871628 306.40031014817765 2.416932832955298 0.01807620755823154 1468.4385463098104 0.029999999976331546 1.5228787456229735 3.6928669121073545 YMNSDTTS(ph)PELR ddPTM_A459_Selumetinib_30min_R2 3 YMNSDTTSPELR 12 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 YMNSDT(0.001)T(0.031)S(0.968)PELR;YMNS(0.002)DT(0.028)T(0.08)S(0.891)PELR;YMNSDTT(0.019)S(0.981)PELR 164.48 0.00051055 101512000.0 237731.0 231068.0 252995.0 260163.0 287569.0 188607.0 188044.0 251123.0 205092.0 222393.0 True False 224518.86273259477 248790.17259927577 236717.57714012824 224728.3505937919 251442.01132052182 214585.90224612068 196788.41860211725 251853.7263543496 246116.13074927352 215971.9362435926 1.0395742457916486 1.1519560222799865 1.0960571139814057 1.0405442230249908 1.1642346486949253 0.9935823421247258 0.9111758778703617 1.1661409844947925 1.139574590245288 1.0 17.7204843327858 -6.771691522977508 24.998821244192598 1.044296157217173 1.0980920135319965 0.11629060549543968 0.07758582593333051 553.7050779277963 1350145.911796632 0.028776950117466303 0.025655604374360184 1.6916420692279435e-07 6.771691522977508 0.05379585631482353 YMPAVTSTPTVNQHETS(ph)TSK ddPTM_A459_Selumetinib_30min_R2 2 YMPAVTSTPTVNQHETSTSK 20 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 YMPAVTSTPTVNQHET(0.185)S(0.569)T(0.185)S(0.06)K;YMPAVTSTPTVNQHET(0.165)S(0.627)T(0.165)S(0.043)K 166.01 2.3509e-09 22813000.0 48493.0 49743.0 56950.0 54837.0 54188.0 43643.0 44632.0 48542.0 38889.0 51468.0 True False 45797.95319285972 53558.12815104553 53285.899002471684 47368.10600089861 47380.41899313359 49654.427098291366 46707.4764366302 48683.24918343932 46667.88664944759 49981.985110076435 0.9162892008390198 1.0715486396367266 1.0661020942869508 0.947703575529839 0.9479499241333982 0.9934464785449462 0.9344862220611143 0.974015919460244 0.9336941409323752 1.0 15.609120580925845 -5.779599223752063 24.999503003692034 0.9601577960850974 1.02333685531069 0.24578938919534155 0.044903818044229465 287.97255150396745 396432.6487802318 0.012333170432821935 0.018333514071225045 1.6611191166433433e-06 5.779599223752063 0.06317905922559264 YMS(ph)FTDK ddPTM_A459_Selumetinib_30min_R1 3 YMSFTDK 7 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 Y(0.001)MS(0.871)FT(0.128)DK;Y(0.001)MS(0.997)FT(0.002)DK;YMS(0.994)FT(0.006)DK 122.28 0.0080859 80699000.0 17249.9 23763.7 15627.8 18261.199999999997 18548.0 21251.0 21906.1 22071.6 13008.7 20160.7 True False 17651.789107537526 20981.4349565556 13505.630597360705 15072.22422517855 16870.33667491536 21037.23423436419 20253.70524029771 21486.189469339108 22074.81378214374 22748.522226847883 0.7759532215549731 0.9223207884595351 0.5936926567221722 0.6625583884033689 0.741601432685809 0.9247736632991472 0.8903305910743607 0.9445092413071577 0.9703845182563539 1.0 14.473485208586297 -6.774155347643076 5.11148262142465 0.9409500736621399 0.7360144331052749 0.6081979260599487 0.08301393287887647 0.14127028253985324 10.18770057632694 0.03136398018538133 0.0289709258517298 1.682072274231187e-07 6.774155347643076 -0.20493564055686497 YMS(ph)FTDK ddPTM_A459_Selumetinib_30min_R2 4 YMSFTDK 7 0 H0YCM0;E9PM17;B3KNX7;Q13153;Q13153-2 H0YCM0 PAK1 Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 1 Y(0.005)MS(0.99)FT(0.006)DK;Y(0.187)MS(0.81)FT(0.002)DK;Y(0.088)MS(0.802)FT(0.11)DK;Y(0.021)MS(0.942)FT(0.037)DK 100.25 0.020692 66040800.0 399119.0 304626.0 331797.0 378002.0 330106.0 352931.0 360557.0 331238.0 275661.0 334808.0 True False 376937.56377994746 327989.8346730267 310449.5422532589 326517.4755101783 288635.1330949167 401544.04166136746 377323.6149301415 332201.8477405968 330800.90261187963 325141.22310434637 1.1593041330812066 1.008761151666598 0.9548144627407871 1.004232783504632 0.8877223575009008 1.2349834875674974 1.1604914668388524 1.0217155627601995 1.0174068346471001 1.0 18.31070695448213 -6.750065904353726 24.999997846351153 1.0928749665423703 1.0006840991075543 0.17130371832843605 0.09179012256869952 393.11976420644055 864113.6216761731 0.031683428321505724 0.03141756141192703 1.778009575932572e-07 6.750065904353726 -0.09219086743481597 YMS(ph)QMSVPEQAELEK ddPTM_A459_Selumetinib_30min_R2 1 YMSQMSVPEQAELEK 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 Y(0.019)MS(0.972)QMS(0.008)VPEQAELEK 96.208 0.039158 3957000.0 32913.0 22855.0 29673.0 44391.0 34221.0 18061.0 27375.0 29874.0 15324.0 23290.0 True False 31083.827221178144 24607.905009592214 27763.871485519627 38344.86922125373 29921.85204037837 20548.738808565857 28647.991742533428 29960.928394093073 18389.22818833434 22617.557185312817 1.3743229194248738 1.0880001234426797 1.2275362568132988 1.6953585618058598 1.3229479998754574 0.9085304235202557 1.2666262544540663 1.3246756998827807 0.8130510310050534 1.0 14.465155498667361 -6.6411367266010854 9.473337929432125 1.095962519488539 1.342824486239996 0.3163826717425946 0.20232566924183792 0.42544952642141964 33.345235977613406 0.06944398404082966 0.06940643505676425 2.284879353826049e-07 6.6411367266010854 0.2468619667514571 YMSQMS(ph)VPEQAELEK ddPTM_A459_Selumetinib_30min_R1 4 YMSQMSVPEQAELEK 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 YMS(0.084)QMS(0.916)VPEQAELEK;YMS(0.08)QMS(0.92)VPEQAELEK;Y(0.001)MS(0.002)QMS(0.997)VPEQAELEK;YMS(0.002)QMS(0.998)VPEQAELEK 216.71 3.4726e-09 52625800.0 6395.1 7125.34 8543.09 7832.67 7004.08 6683.039999999999 6737.280000000001 7087.03 4286.83 6008.12 True False 6544.093387301567 6291.1018803193065 7382.985301834312 6464.84122192568 6370.56220067076 6615.814685314815 6229.081545384754 6899.058942482214 7274.437412324624 6779.3207260446925 0.9653022259531944 0.9279841055683125 1.0890449943562148 0.9536119447910393 0.9397050911305066 0.9758816484221313 0.9188356469777218 1.0176622734454077 1.0730333769838916 1.0 12.72692501019755 -7.984620859633568 22.638458515644714 1.0394604141985364 0.9690650526860194 0.2755550584071832 0.0473830377519959 92.48186346408468 136134.97059927118 0.026014388227431504 0.012485387806636343 1.0360462434240455e-08 7.984620859633568 -0.07039536151251702 YMSQMS(ph)VPEQAELEK ddPTM_A459_Selumetinib_30min_R2 5 YMSQMSVPEQAELEK 15 0 A0A5H1ZRS1;Q15154-5;A0A4W8VX11;Q15154;Q15154-4;Q15154-2;E7EV93;E9PGW9;E5RGQ4;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 YMS(0.264)QMS(0.736)VPEQAELEK;Y(0.002)MS(0.002)QMS(0.996)VPEQAELEK;YMSQMS(1)VPEQAELEK;YMS(0.046)QMS(0.954)VPEQAELEK;YMSQMS(1)VPEQAELEK 249.89 5.1539e-28 74411400.0 294119.0 197261.0 284814.0 313979.0 344205.0 133185.0 217440.0 263031.0 153007.0 193683.0 True False 277773.043431644 212390.2844059142 266489.37732203695 271214.5185560144 300962.89066825726 151530.02481694496 227551.39084918614 263796.37666287407 183612.6753727797 188090.86854113088 1.4768023859217907 1.129189769036925 1.4168118813474575 1.441933468964265 1.6000930454656497 0.8056213786040817 1.2097949922509195 1.4024943300487138 0.9761913313331746 1.0 17.521070284859825 -6.74803814188909 24.99999989482656 1.1121621477044226 1.3990236626804549 0.4447678460171879 0.18447422315270473 265.14882954988497 494634.13269845163 0.06256298117950343 0.062223053163285164 1.7863306835682072e-07 6.74803814188909 0.2868615149760323 YNAPTSHVT(ph)PSVK ddPTM_A459_Selumetinib_30min_R1 2 YNAPTSHVTPSVK 13 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 YNAPTSHVT(0.92)PS(0.079)VK;YNAPTSHVT(0.94)PS(0.06)VK 214.89 3.1588e-06 32629000.0 6691.700000000001 9199.400000000001 8915.5 9605.8 9074.0 7586.7 8267.9 8053.0 3990.1 6117.4 True False 6847.603590218427 8122.329971314973 7704.82406933601 7928.32735319804 8253.258302144814 7510.384686172449 7644.245646475525 7839.408280169443 6770.908274626346 6902.627878522031 0.9920285014241003 1.176701122276651 1.1162160563964434 1.1485955048898897 1.1956690187262384 1.0880471638260396 1.1074399172322595 1.1357135888148142 0.9809174699529234 1.0 12.752929995182875 -8.262058890676743 24.98217853007095 0.9904587174835956 1.1237967154898183 0.4898321529475851 0.05279154585145093 43.41240104533214 1750416.6613831297 0.04064053639265142 0.012876782787005119 5.4694179212378375e-09 8.262058890676743 0.1333379980062227 YNAPTSHVT(ph)PSVK ddPTM_A459_Selumetinib_30min_R2 1 YNAPTSHVTPSVK 13 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 YNAPT(0.03)S(0.03)HVT(0.47)PS(0.47)VK 106.76 0.01602 4685000.0 36877.0 25663.0 34746.0 40379.0 38454.0 30009.0 33084.0 32905.0 25433.0 27907.0 True False 34827.523970327406 27631.26958044914 32510.480188584377 34879.310542339765 33623.06473687827 34142.46735542067 34622.47155470232 33000.74810228399 30520.31065739411 27101.25239890619 1.2850890969058335 1.0195569257738193 1.199593277464052 1.2869999522142932 1.2406461606267059 1.2598114232093076 1.2775229367665566 1.2176835083686357 1.1261586810883293 1.0 14.72607190227037 -8.55349728840886 2.4958542594875333 1.000744253118529 1.2215944920796384 0.47223882201626266 0.07394959897156804 0.2851245714722703 4.265793803668732 0.07480123467183115 0.02029540624696774 2.795778183440857e-09 8.55349728840886 0.22085023896110934 YNAPTSHVTPS(ph)VK ddPTM_A459_Selumetinib_30min_R1 1 YNAPTSHVTPSVK 13 0 A0A087X2D8;O60271-4;O60271-2;O60271-5;O60271-9;O60271;O60271-3 A0A087X2D8;O60271 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 1 YNAPTSHVT(0.251)PS(0.749)VK 79.471 0.025810000000000003 19071000.0 5286.6 7543.1 7069.8 7349.6 7001.4 6384.3 7421.8 6313.8 3809.6 5277.6 True False 5409.76749406709 6659.95034530795 6109.759991631622 6066.130329078716 6368.1246061975635 6320.079738480603 6861.967650674536 6146.337513887223 6464.612957824754 5955.03136817731 0.9084364396426158 1.1183736799267943 1.0259828393652393 1.018656318335299 1.0693687761625832 1.0613008307989864 1.1522974819819998 1.032125128128161 1.0855716046048998 1.0 12.53989339217963 -6.280685216584744 9.99492097260669 1.0724072794847417 1.0256197502738627 0.12876747665062338 0.05994799092862225 0.9715993755780091 492.9670981531262 0.017724886701515855 0.02048106458804283 5.239800879220719e-07 6.280685216584744 -0.04678752921087903 YNDWS(ph)DDDDDSNESK ddPTM_A459_Selumetinib_30min_R1 1 YNDWSDDDDDSNESK 15 0 H3BV87;Q9UH62 H3BV87 ARMCX3 Armadillo repeat-containing X-linked protein 3 1 YNDWS(1)DDDDDSNESK 254.59 1.4439e-28 10571000.0 1077.2 1217.8 1250.1 1013.9 1065.1 932.03 1021.8 1056.1 677.11 912.82 True False 1102.2966641336714 1075.219409860139 1080.3432863077724 836.8413982601654 968.761893058678 922.6546244155309 944.7248033440998 1028.0887973037316 1149.0062158422716 1029.9893386197543 1.070202013557551 1.043913145063225 1.0488878338833052 0.8124757867703578 0.9405552627922104 0.8957904609497626 0.9172180409266042 0.9981547951568415 1.1155515622928747 1.0 10.008413688866684 -10.93251852776577 14.655111843297558 1.0000000000440137 0.9760365297872683 0.0 0.08754737623769676 1.854399279363889e-10 0.0 0.0907010041264982 0.021998224563343716 1.1681038954334671e-11 10.93251852776577 -0.02396347025674539 YNDWS(ph)DDDDDSNESK ddPTM_A459_Selumetinib_30min_R2 1 YNDWSDDDDDSNESK 15 0 H3BV87;Q9UH62 H3BV87 ARMCX3 Armadillo repeat-containing X-linked protein 3 1 YNDWS(1)DDDDDSNESK 99.663 0.0080899 11360000.0 31953.0 20538.0 25342.0 27217.0 24096.0 18184.0 30754.0 24921.0 17389.0 24136.0 True False 30177.18017799367 22113.19855992147 23711.52331028336 23509.997648056196 21068.845059026844 20688.680942083043 32184.121937894917 24993.515984106347 20867.28588925514 23439.130967140853 1.2874700952138045 0.9434308204908195 1.01162126460765 1.0030234346578246 0.8988748383446086 0.8826556313494026 1.3730936519367378 1.066315812610313 0.8902755788390294 1.0 14.516631460715836 -4.752289583490302 24.9972374262521 1.013858053606778 1.287470626505889 0.2772111124018015 0.13519775620424124 534.1130688889102 1459090.850355664 0.035179387616302495 0.4266313432926932 1.7689290596699684e-05 4.752289583490302 0.273612572899111 YNDWSDDDDDS(ph)NESK ddPTM_A459_Selumetinib_30min_R1 1 YNDWSDDDDDSNESK 15 0 H3BV87;Q9UH62 H3BV87 ARMCX3 Armadillo repeat-containing X-linked protein 3 1 YNDWS(0.003)DDDDDS(0.997)NESK 203.52 9.2967e-06 11457000.0 1909.6 2025.9 2533.3 2264.6 2029.2 1856.0 1890.9 2189.6 889.55 1739.6 True False 1954.089964565223 1788.7066861846424 2189.291774420832 1869.1301218068547 1845.659218284357 1837.3303251131686 1748.2678906276767 2131.524695176829 1509.5013798385667 1962.8946051389362 0.9955144608627166 0.9112596679932469 1.1153384235145276 0.9522315242567776 0.9402742324790886 0.9360310636663653 0.8906580547170703 1.0859088865986042 0.7690180491029075 1.0 10.938766996067574 -5.975558743453616 24.954445663863037 0.9395806119174761 1.0037639352747565 0.11300114825733454 0.08811044829468212 521.6002728752113 532548.1880498412 0.02341349421314205 0.03472601681953879 1.0578918139667243e-06 5.975558743453616 0.06418332335728039 YNEWADDRR ddPTM_A459_Selumetinib_30min_R2 1 YNEWADDRR 9 1 Q92620 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 96.665 0.028793 2791300.0 16668.0 17317.0 19822.0 16437.0 17808.0 14932.0 15691.0 14383.0 12679.0 16336.0 False True 15741.659287290642 18645.15821706884 18546.67410056179 14198.252244593448 15570.799834460087 16988.747460799827 16420.662591126642 14424.852148766175 15215.154280859515 15864.33723397468 0.992267061341755 1.1752875611556481 1.169079667623472 0.8949792251129669 0.9814970272514152 1.0708765963709557 1.0350676708990116 0.9092628286969506 0.9590791002775149 1.0 13.953499630446935 -5.75220278155542 24.999961811067653 0.9812079742847585 1.1185190519354649 0.44703270364339975 0.0679075740444712 184.08280430702987 498237.19961515686 0.01923972847522258 0.03274213449970538 1.7692826488060178e-06 5.75220278155542 0.13731107765070638 YNGLIHR ddPTM_A459_Selumetinib_30min_R1 1 YNGLIHR 7 0 P46779;H0YMF4;H0YKD8;P46779-4;P46779-5;P46779-2;P46779-3;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 95.793 0.033104 7226900.0 7959.8 8563.8 9614.7 10241.0 8481.1 7181.6 7994.4 6929.9 5056.4 5963.7 False True 8145.247852925364 7561.14631479739 8309.076549766689 8452.601597378789 7713.986002459816 7109.359624371081 7391.375971671635 6746.09654051238 8580.34149515568 6729.198986357253 1.210433495790361 1.1236324457230087 1.2347794390703073 1.2561081362752915 1.1463453552345704 1.0564941888008608 1.0984035375765937 1.0025110795786223 1.2750910639663688 1.0 12.716219067775961 -6.529774626144365 5.599111122090994 1.0882134451018275 1.202601683080301 0.34124361727987473 0.07835066654709062 0.19627210261776604 21.25893866642168 0.024769993143722552 0.025829337070533604 2.9527411319534445e-07 6.529774626144365 0.11438823797847353 YNGLIHR ddPTM_A459_Selumetinib_30min_R2 2 YNGLIHR 7 0 P46779;H0YMF4;H0YKD8;P46779-4;P46779-5;P46779-2;P46779-3;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 ; 133.47 0.004531100000000001 12363700.0 133436.0 124225.0 145190.0 155601.0 160611.0 123232.0 123914.0 123471.0 117639.0 123377.0 False True 126020.1613066303 133752.65805366836 135848.63347091948 134407.875373303 140433.61029944223 140206.08941128346 129676.24653093291 123830.28016827561 141170.08710829163 119814.78543805645 1.0517914032553353 1.116328486210224 1.133821948386766 1.1217970710533975 1.1720891523195656 1.17019021399299 1.082305877833206 1.0335141837089477 1.1782359463580205 1.0 16.870446425651707 -11.256857954896237 6.292392451131542 0.9975008779916318 1.1179491112606015 0.3585172133826199 0.04726594856078023 0.0017412503509684762 7.36139886942375e-05 0.048088559232573616 0.011436051369521999 5.53531123555905e-12 11.256857954896237 0.1204482332689697 YNLDAS(ph)EEEDSNK ddPTM_A459_Selumetinib_30min_R1 4 YNLDASEEEDSNK 13 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 YNLDAS(1)EEEDSNK;Y(0.009)NLDAS(0.99)EEEDS(0.001)NK;YNLDAS(0.993)EEEDS(0.007)NK;Y(0.152)NLDAS(0.843)EEEDS(0.005)NK 278.85 1.8467e-48 113879000.0 17694.2 27282.3 10019.699999999999 10704.900000000001 12630.8 15090.8 19235.6 18032.5 10314.2 21392.9 True False 18106.440433080228 24088.07563280283 8659.079774272443 8835.49017086029 11488.346370148864 14939.000253350096 17784.6432053296 17554.219522184972 17502.444080637346 24138.88709949228 0.7500942507602625 0.997895036897102 0.3587190966419728 0.36602723789391806 0.4759269274841797 0.6188769263378473 0.7367631793473888 0.7272174334231919 0.7250725358007694 1.0 14.559071543088336 -8.581990099348547 0.7822748527694321 0.9927783207845549 0.5959366222121181 0.29672858258327917 0.1804181982081193 1.0731905793362406 1.4555702713797212 0.19644124558986467 0.07245165010134191 2.6182426958594187e-09 8.581990099348547 -0.3968416985724368 YNLDAS(ph)EEEDSNK ddPTM_A459_Selumetinib_30min_R2 4 YNLDASEEEDSNK 13 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 Y(0.004)NLDAS(0.995)EEEDS(0.001)NK;YNLDAS(1)EEEDSNK;YNLDAS(0.802)EEEDS(0.198)NK;YNLDAS(1)EEEDSNK 203.05 6.4523e-05 173381000.0 299573.9 192382.3 218505.0 240552.8 240474.2 216545.1 310402.7 301167.8 237717.4 191017.1 True False 282924.78192733845 207137.4038034074 204446.62619025607 207789.09366327434 210263.68112937562 246372.22192429972 324837.0406012818 302044.14843698655 285267.52237911394 185501.94000097158 1.5251850300102339 1.1166320082815442 1.1021266202886355 1.1201451244239604 1.1334850790685767 1.328138249783314 1.751124762358714 1.6282533133368016 1.5378142265122394 1.0 17.50107474923516 -7.021881254902325 6.739291989043743 1.5337615110512348 1.1887929065845206 0.253716297945374 0.21790808624774163 0.19330680586982904 36.279360279474645 0.0787134066574926 0.0634799555407384 9.508647442128771e-08 7.021881254902325 -0.3449686044667142 YNLDAS(ph)EEEDSNKK ddPTM_A459_Selumetinib_30min_R1 3 YNLDASEEEDSNKK 14 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 YNLDAS(0.809)EEEDS(0.191)NKK;YNLDAS(0.999)EEEDS(0.001)NKK;YNLDAS(0.982)EEEDS(0.018)NKK 239.51 3.1291e-19 154101000.0 8382.1 11958.099999999999 7241.0 7223.0 6487.9 7696.9 9397.5 8762.3 5561.5 9625.8 True False 8577.386621272602 10558.04009283013 6257.711971965909 5961.638642502389 5901.070590531778 7619.476174226043 8688.639009029348 8529.89534003833 9437.459304111286 10861.365193231999 0.7897153321589258 0.9720730225891973 0.5761441458450594 0.5488848350497636 0.5433083673688544 0.7015210370583929 0.7999582791345112 0.7853428356642986 0.8689017573952871 1.0 13.406917830179852 -8.255069303038551 1.024742712858759 0.9911493243670281 0.6892377472412028 0.38873563255505705 0.1226966566080408 0.5918551950920525 1.273871135792387 0.1306586451459154 0.04486553533510798 5.558155552904393e-09 8.255069303038551 -0.3019115771258253 YNLDAS(ph)EEEDSNKK ddPTM_A459_Selumetinib_30min_R2 1 YNLDASEEEDSNKK 14 1 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 YNLDAS(0.999)EEEDS(0.001)NKK 103.41 0.0035447 179250000.0 141330.0 102780.0 115850.0 112610.0 87979.0 80565.0 125520.0 134030.0 89818.0 77072.0 True False 133475.4443888162 110662.89551021167 108396.33712794271 97272.32373691497 76926.29147776071 91662.09745374609 131356.92871316147 134420.0051101391 107784.1097246027 74846.73110289541 1.7833169521501353 1.4785267690325454 1.4482441053962 1.2996202012241524 1.0277842511519497 1.2246640047343387 1.7550122333676639 1.7959368850103212 1.440064357338822 1.0 16.191651688156114 -7.252424693884539 24.84431881052922 1.5640814472246796 1.3654838358794532 0.021458982535163762 0.2749911642170733 1492.0639381354167 4112111.8490067124 0.10921964813597661 0.0833540942729125 5.592104855570808e-08 7.252424693884539 -0.19859761134522635 YNLDAS(ph)EEEDSNKKK ddPTM_A459_Selumetinib_30min_R1 1 YNLDASEEEDSNKKK 15 2 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 1 YNLDAS(1)EEEDSNKKK 87.66799999999998 0.020821 46101000.0 4755.7 5192.1 5059.1 4822.0 3372.7 4481.1 4553.4 4590.3 2885.5 5079.8 True False 4866.498557018663 4584.206518258197 4372.10200764711 3979.928220150429 3067.6398804985465 4436.024202513266 4209.933372036628 4468.550332604221 4896.482751418342 5731.841811442155 0.8490287619773359 0.7997789661792485 0.7627743666825082 0.694354162427428 0.5351926974632811 0.773926487932357 0.7344817792480898 0.7796011264099969 0.8542599242086143 1.0 12.48478307901492 -8.537121805439911 1.3302166813300984 0.9989398865046989 0.7303821234884922 0.5229621538920897 0.07835927608129119 0.41201588437364606 1.6009326275075464 0.08131126384245253 0.024678839280650577 2.90320828501689e-09 8.537121805439911 -0.2685577630162067 YNLINEGS(ph)PPSK ddPTM_A459_Selumetinib_30min_R1 3 YNLINEGSPPSK 12 0 Q68D06 Q68D06 SLFN13 Schlafen family member 13 1 YNLINEGS(0.964)PPS(0.036)K;YNLINEGS(1)PPSK;YNLINEGS(0.72)PPS(0.28)K 138.42 0.0012423 17920000.0 8049.5 10070.4 11000.5 11268.400000000001 9167.5 9669.6 8638.199999999999 8541.8 4653.02 7143.1 True False 8237.037688399543 8891.352886398048 9506.69252142121 9300.585474065338 8338.301243653585 9572.332603294331 7986.613619345282 8315.243716323277 7895.835096865212 8059.986464686098 1.0219666899552715 1.103147371940944 1.1794923680174512 1.1539207311097583 1.0345304275865588 1.1876363124472236 0.9908966540251289 1.0316696873816797 0.9796337911310278 1.0 12.976561700667608 -7.283287379429515 24.601272478800848 1.003189156069559 1.1142351204211605 0.5241996702418805 0.052666600397266485 563.1735027334018 634141.0326456252 0.022146240957155592 0.01494669114924542 5.208499425210441e-08 7.283287379429515 0.11104596435160152 YNLINEGS(ph)PPSK ddPTM_A459_Selumetinib_30min_R2 2 YNLINEGSPPSK 12 0 Q68D06 Q68D06 SLFN13 Schlafen family member 13 1 YNLINEGS(0.99)PPS(0.01)K;YNLINEGS(0.995)PPS(0.005)K 156.2 0.00043309 12327000.0 152205.0 136207.0 168896.0 166247.0 170284.0 166914.0 136502.0 141160.0 118649.0 155271.0 True False 143746.05542489048 146653.63892546642 158029.4152400606 143603.87180792878 148891.40156172504 189904.88840556785 142849.61347358156 141570.75222970403 142382.11533004965 150787.92278749304 0.9532995266966656 0.9725821286904184 1.0480243531358482 0.9523565889975896 0.9874225920039976 1.2594170998243854 0.9473544752977398 0.9388732838320291 0.94425410668141 1.0 17.202161356409825 YNSYDIS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 YNSYDISR 8 0 G3V1S3;Q6ZUT9;Q6ZUT9-2;H0YGE5;Q6ZUT9-3;Q6ZUT9-4 G3V1S3 DENND5B DENN domain-containing protein 5B 1 Y(0.003)NS(0.05)YDIS(0.946)R;Y(0.022)NS(0.094)YDIS(0.884)R 112.85 0.010999 14006800.0 104278.0 87776.0 108487.0 123016.0 127631.0 79393.0 84022.0 89240.0 73791.0 93035.0 True False 98482.64621790833 94508.13695567568 101507.06453171454 106261.00858556342 111596.85274438302 90328.66509210286 87929.18948643452 89499.67362552279 88551.26189280745 90348.83781604019 1.0900267075756904 1.0460360004641593 1.12350160760666 1.1761192634477722 1.2351775124280628 0.9997767240351403 0.9732188217569292 0.9906012715709039 0.980104050404137 1.0 16.463218422943484 -6.885562200306451 8.673752970542228 0.9854742069411282 1.1308111647887056 0.7037646419128534 0.04720972220108068 0.16577914581964112 11.92469639556336 0.0187495212437915 0.01654018833054132 1.3014809021854132e-07 6.885562200306451 0.14533695784757739 YNTEGRVS(ph)PSPSQESLSSSK ddPTM_A459_Selumetinib_30min_R1 2 YNTEGRVSPSPSQESLSSSK 20 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83;Q5JSH3-3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 Y(0.006)NT(0.028)EGRVS(0.96)PS(0.005)PS(0.001)QESLSSSK;YNTEGRVS(0.999)PS(0.001)PSQESLSSSK 101.3 0.00038965 47562000.0 4970.3 5760.2 5190.1 5588.6 5512.5 4711.1 5400.200000000001 5291.9 2643.3999999999996 4562.0 True False 5086.0983194797545 5085.793106155667 4485.3129271786 4612.655921014661 5013.895348310921 4663.710611336553 4992.858566274039 5151.541621486235 4485.656733702738 5147.57713764304 0.9880567465975972 0.987997453979745 0.8713444805670895 0.8960829138981474 0.9740301532628748 0.9060011121022191 0.9699434185769494 1.0007701650188403 0.8714112705373891 1.0 12.329677828803007 -7.307401638144781 24.972380149918518 0.9605953962957134 0.936363292322334 0.0497773438215382 0.049736143389003076 1579.76418246694 858317.5947075761 0.021196803828418417 0.01429091728896664 4.927179246919855e-08 7.307401638144781 -0.024232103973379493 YNTEGRVS(ph)PSPSQESLSSSK ddPTM_A459_Selumetinib_30min_R2 3 YNTEGRVSPSPSQESLSSSK 20 1 Q5JSH3-2;Q5JSH3;Q5JSH3-4;H7BY83;Q5JSH3-3 Q5JSH3-2 WDR44 WD repeat-containing protein 44 1 YNTEGRVS(0.774)PS(0.086)PS(0.086)QES(0.05)LS(0.001)SSK;Y(0.014)NT(0.006)EGRVS(0.949)PS(0.028)PS(0.002)QESLSSSK;Y(0.001)NT(0.001)EGRVS(0.942)PS(0.032)PS(0.023)QES(0.001)LSSSK 71.426 0.005381 54245000.0 126298.0 103231.0 121211.0 119000.0 113735.0 69375.0 81859.0 93510.0 67868.0 94021.0 True False 119278.86277095227 111148.48576001824 113412.41622455849 102791.99471355 99446.59249619927 78930.77652645233 85665.60570053122 93782.0986185861 81443.4963903599 91306.3694341045 1.3063586199978678 1.21731360527081 1.2421084851742774 1.12579215831963 1.0891528500426197 0.8644607929944734 0.9382215745896654 1.0271145288091683 0.891980448846314 1.0 16.478427884123413 -6.1990454460723985 1.4562548414687184 0.946922496225418 1.2586746754303002 0.8495598370706461 0.05603411623868062 0.14657595760563932 0.6230077781755331 0.02057078280015542 0.030059519359123835 6.323456770814178e-07 6.1990454460723985 0.3117521792048822 YNVSTT(ph)PYLQSVK ddPTM_A459_Selumetinib_30min_R1 1 YNVSTTPYLQSVK 13 0 Q8WWK9-6;Q8WWK9-5;Q8WWK9 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 YNVS(0.004)T(0.014)T(0.982)PYLQSVK 108.23 0.014842 20572000.0 1631.7 2089.8 2034.8 2230.2 1792.5 1760.1 2183.0 1962.6 955.17 1553.8 True False 1669.7154352644943 1845.1252444783377 1758.4853363563368 1840.7374360388799 1630.368691491579 1742.394992042935 2018.334552456618 1910.5454725767486 1620.8537271433916 1753.2453652936754 0.9523569651557644 1.0524056022068948 1.0029887266017576 1.0499029243009288 0.9299147305708041 0.993811263691022 1.1511991375596986 1.0897193914764605 0.9244876725351515 1.0 10.775812198911915 YNVSTT(ph)PYLQSVK ddPTM_A459_Selumetinib_30min_R2 1 YNVSTTPYLQSVK 13 0 Q8WWK9-6;Q8WWK9-5;Q8WWK9 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 YNVS(0.007)T(0.026)T(0.966)PYLQSVK 91.712 0.045422 9800300.0 62276.0 63045.0 66560.0 76427.0 70660.0 64255.0 72976.0 54969.0 48457.0 84132.0 True False 58814.94923058028 67880.34877837425 62277.60206504863 66017.51075607135 61783.059091585164 73105.5430011849 76369.52859920074 55128.95068939218 58149.75400170432 81702.89055881237 0.7198637505761608 0.8308194277350786 0.7622447827622354 0.8080192794225538 0.7561918393463904 0.894773030686854 0.9347224813818245 0.6747490855260326 0.711722114162488 1.0 16.318099499794272 -6.714679065645094 24.99834444926371 0.8285864284438322 0.7795833745899119 0.10273132139239294 0.09497332881195211 419.7085438364791 224377.22764493566 0.03230084953545111 0.03230075388207684 1.9289498394013574e-07 6.714679065645094 -0.04900305385392034 YNVTTS(ph)KQLY(ph)TVAVS(ph)CLLLAS(ph)K ddPTM_A459_Selumetinib_30min_R2 1 YNVTTSKQLYTVAVSCLLLASK 22 1 E5RFJ6;E7EN43;B4DZA8 E5RFJ6 CCNJL 4 Y(0.304)NVT(0.401)T(0.433)S(0.456)KQLY(0.404)T(0.002)VAVS(1)CLLLAS(1)K 71.97399999999998 0.00248 33398000.0 31153.0 37244.0 32550.0 27615.0 26339.0 18843.0 15351.0 19266.0 15820.0 33300.0 True False 29421.6409753399 40100.49504166496 30455.768437760373 23853.789361467916 23030.05934635244 21438.45221027665 16064.85191742942 19322.06087034201 18984.442047732264 32338.542476209397 0.9098010832425306 1.2400217193204 0.9417792548988833 0.7376272254390102 0.7121551431483047 0.662938109410724 0.49677105668098376 0.5974932508030235 0.5870531135315888 1.0 14.98096703641512 -5.742363442820595 2.2387128113291546 0.6485757955728186 1.0816011219227282 0.5460542264015766 0.14655760212392907 0.19759240574907452 2.018258996141212 0.04202954984301557 0.08095325087716373 1.8098248922268203e-06 5.742363442820595 0.43302532634990953 YNVTTSKQLY(ph)T(ph)VAVS(ph)CLLLAS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 YNVTTSKQLYTVAVSCLLLASK 22 1 E5RFJ6;E7EN43;B4DZA8 E5RFJ6 CCNJL 4 Y(0.247)NVT(0.31)T(0.329)S(0.343)KQLY(0.497)T(0.273)VAVS(1)CLLLAS(1)K 54.855 0.02727 92689000.0 2862.2 4248.5 3889.6 4498.3 3209.7 2932.8 2892.4 2382.8 1013.5 2283.1 True False 2928.883691128292 3751.0836449259327 3361.413684043446 3712.7563485488745 2919.3832017185596 2903.2986947693407 2674.2239393154014 2319.600403574787 1719.8354768887498 2576.15812427725 1.1369192222818234 1.4560766319335745 1.3048165220783963 1.441198936338778 1.133231370468613 1.12698776810677 1.038066690904567 0.9004107246815678 0.667597016146381 1.0 11.331005433281288 -7.137356536404811 1.0488823029557657 0.8333771840431908 1.3357726705671833 0.713217448585185 0.12267772515041828 0.26616761712769 0.5855437841405702 0.0802385420629967 0.05076814309482782 7.288589039127346e-08 7.137356536404811 0.5023954865239925 YPDLYPQEDEDEEEEREK ddPTM_A459_Selumetinib_30min_R1 1 YPDLYPQEDEDEEEEREK 18 1 Q8N4Q1;Q8N4Q1-2 Q8N4Q1 CHCHD4 Mitochondrial intermembrane space import and assembly protein 40 0 107.62 0.004443600000000001 3497400.0 845.93 1087.2 1085.2 1131.2 828.96 971.14 983.22 1180.8 470.78 959.48 False True 865.6385231067551 959.9101185744323 937.8358005769102 933.65715525387 753.9807143647746 961.3712133245693 909.0549238050368 1149.481348221046 798.8792755892316 1082.638604126642 0.7995636954079063 0.8866394703787476 0.8662501013747397 0.8623904151349245 0.6964288096608252 0.8879890386876623 0.83966609018008 1.0617405880777044 0.737900230551711 1.0 10.080336021563747 -7.573888045285919 24.999897176797987 0.9300331285109258 0.8348805197971049 0.1918153673320352 0.09317390805792909 177.02874438704637 86760.5256749693 0.041522710685183394 0.023973153208542625 2.6675462299826285e-08 7.573888045285919 -0.09515260871382092 YPDLYPQEDEDEEEEREK ddPTM_A459_Selumetinib_30min_R2 1 YPDLYPQEDEDEEEEREK 18 1 Q8N4Q1;Q8N4Q1-2 Q8N4Q1 CHCHD4 Mitochondrial intermembrane space import and assembly protein 40 0 94.882 0.011656 2462200.0 3263.8 1070.3 1998.3 4167.8 2527.1 3160.8 2093.2 2007.7 2000.9 2280.3 False True 3082.411062026591 1152.3885684430784 1869.7315535845328 3600.138450143979 2209.623105439356 3596.17150911439 2190.5379475971126 2013.5420746073726 2401.1359098171633 2214.4618140690777 1.3919459086822794 0.5203921608047791 0.8443277466812117 1.62573968413965 0.9978149505225242 1.6239483048508379 0.989196532394476 0.9092692688646933 1.084297726229504 1.0 11.112740404428482 -4.4300778312235956 23.230518038606363 1.0790468408773985 46.185769871409875 0.084971345526486 0.31823746979547357 2575.162550569817 644574.7871189984 0.07885449901258047 552.8831934975866 3.7146865111450406e-05 4.4300778312235956 45.10672303053248 YPDVAS(ph)PTLR ddPTM_A459_Selumetinib_30min_R1 2 YPDVASPTLR 10 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;E9PNV5 A0A0A0MTL4 NAV2 Neuron navigator 2 1 YPDVAS(0.5)PT(0.5)LR;YPDVAS(0.723)PT(0.277)LR 126.71 0.0034106 28680000.0 5775.6 7017.9 6421.5 6457.4 6111.3 5425.8 6306.4 5257.0 3037.2 4981.5 True False 5910.160242638723 6196.241005466804 5549.495570774624 5329.736310410488 5558.533994037652 5371.221378232232 5830.703170688229 5117.567282857415 5153.906571688713 5620.924048919067 1.0514570542498751 1.1023527362299752 0.9872923957835404 0.9481957528736621 0.988900391761491 0.9555762240311976 1.0373211094730062 0.910449463169948 0.9169144658127583 1.0 12.456591605714733 -5.371571259725213 4.692394103402385 0.9654254975273204 1.0762304844314885 0.5770431894938808 0.037557475918836666 0.1483770237592486 5.091745596058961 0.01006649470187549 0.021972133324078234 4.2503896001814145e-06 5.371571259725213 0.11080498690416807 YPDVAS(ph)PTLR ddPTM_A459_Selumetinib_30min_R2 4 YPDVASPTLR 10 0 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;E9PNV5 A0A0A0MTL4 NAV2 Neuron navigator 2 1 YPDVAS(0.686)PT(0.314)LR;YPDVAS(0.5)PT(0.5)LR;YPDVAS(0.722)PT(0.278)LR;YPDVAS(0.883)PT(0.117)LR 138.63 0.0016163 40721200.0 139351.0 111680.0 143501.0 134336.0 133364.0 99514.0 108033.0 110108.0 95104.0 95142.0 True False 131606.42928625154 120245.49689220107 134268.30189207525 116039.20505747446 116609.6220307127 113221.15020185064 113056.74856332838 110428.39605063936 114127.45742778298 92395.00325139695 1.4243890324692612 1.3014285693028864 1.4531987355067841 1.2559034685213892 1.2620771462438325 1.2254033899840662 1.2236240552501851 1.1951771434021758 1.2352124401928353 1.0 16.495527211933712 -1.522878745294444 0.03198162576673961 3.642236077665122e-10 3.133888196541858 0.8075541500395119 0.05208519872224428 492.07410042794214 1.2097555943883858 36.7119195322382 94.14856306498042 0.02999999999902557 1.522878745294444 3.1338881961776344 YPDVAS(ph)PTLRR ddPTM_A459_Selumetinib_30min_R2 2 YPDVASPTLRR 11 1 A0A0A0MTL4;A0A0A0MTE8;Q8IVL1-4;Q8IVL1-8;Q8IVL1-9;Q8IVL1-10;Q8IVL1-13;Q8IVL1-12;Q8IVL1-11;Q8IVL1-3;Q8IVL1-2;Q8IVL1;Q8IVL1-5;E9PNV5 A0A0A0MTL4 NAV2 Neuron navigator 2 1 YPDVAS(0.5)PT(0.5)LRR;YPDVAS(0.831)PT(0.169)LRR 75.102 0.027678 9519700.0 59415.0 59868.0 64393.0 56945.0 63935.0 38382.0 35413.0 36956.0 27101.0 51156.0 True False 56112.95215708989 64459.683094039225 60250.024485797374 49188.99276439582 55902.913713848015 43668.77210289436 37059.77466952828 37063.53584160484 32521.957265208093 49678.99336074979 1.1295106515065465 1.2975239378535257 1.2127867416371507 0.9901366641470416 1.1252827388812512 0.8790188598587032 0.7459848149581939 0.7460605244648107 0.6546420340896628 1.0 15.600348320254225 -6.6705863467542414 1.1576479292821533 0.7555781478531887 1.201206704244465 0.7117461251726882 0.11061605540579758 0.23530461952695686 0.6692202076977778 0.05374146967658957 0.05295223235757097 2.1350775461279614e-07 6.6705863467542414 0.4456285563912763 YPGGS(ph)PIPADPR ddPTM_A459_Selumetinib_30min_R2 1 YPGGSPIPADPR 12 0 Q9BY89 Q9BY89 KIAA1671 Uncharacterized protein KIAA1671 1 YPGGS(1)PIPADPR 95.094 0.018353 5436900.0 25274.0 20293.0 20840.0 20913.0 29419.0 17493.0 21991.0 18133.0 18987.0 22195.0 True False 23869.372259838237 21849.407847720624 19499.17708887639 18064.61332306276 25723.122210803078 19902.5019643565 23013.62507433983 18185.764027920246 22784.93054110573 21554.172680464493 1.107413057030582 1.0136973555716067 0.9046590364634761 0.8381028393372539 1.1934172836110333 0.9233711847541717 1.0677108982799466 0.8437235934554247 1.0571006773902636 1.0 14.395679567781588 -9.156491608347332 0.003304784078972379 9.123232670389822e-05 1.961821390517957 0.0 0.11060271529062168 296896.5488822567 374.61815694710805 112210.84007427534 110153.51458858493 6.974424730797737e-10 9.156491608347332 1.961730158191253 YPHVEDYR ddPTM_A459_Selumetinib_30min_R2 2 YPHVEDYR 8 0 A0A087WTV2;K9J957;P61289;P61289-3;P61289-2;B3KQ25;K7ESG5 A0A087WTV2 PSME3 Proteasome activator complex subunit 3 0 ; 103.56 0.021516 6211900.0 20788.7 22630.3 19866.2 22905.8 23938.1 17719.8 22487.5 19884.3 20352.1 22128.3 False True 19633.34727775972 24365.97124211658 18588.03032068311 19785.990525291025 20930.781868670743 20160.541605671082 23533.21330813589 19942.160020976935 24423.0886851866 21489.398482771918 0.9136294481904556 1.1338600874124427 0.8649860690882138 0.9207326366605134 0.9740050139351728 0.938162211559054 1.0951080518611307 0.9279999175856222 1.1365180232832774 1.0 14.391337479901587 -7.240615475097301 24.604140962359654 1.033906501364267 0.9604413707265892 0.18620390050413338 0.08383009805693059 1262.3076128371138 1491461.209315275 0.031090076200376106 0.024053674394376036 5.746250107759539e-08 7.240615475097301 -0.07346513063767779 YPHVEDYRR ddPTM_A459_Selumetinib_30min_R2 1 YPHVEDYRR 9 1 A0A087WTV2;K9J957;P61289;P61289-3;P61289-2;B3KQ25;K7ESG5 A0A087WTV2 PSME3 Proteasome activator complex subunit 3 0 78.77 0.034168000000000004 1579600.0 2247.7 2981.9 2778.6 2781.9 3500.6 2375.4 905.9 1136.6 971.89 3287.4 False True 2122.78183225601 3210.602141680292 2599.8279011109375 2403.0004209548283 3060.823332238935 2702.5897882657296 948.0261450067958 1139.9073178257408 1166.2951568755068 3192.4842203090348 0.6649310335668702 1.005675179615924 0.8143588884706444 0.752705496762711 0.9587591107788296 0.8465475791777342 0.29695562439303963 0.35705965610548795 0.36532526909799684 1.0 11.640463773708907 -7.246396418231735 23.97438447345614 0.45125678795326196 0.8482014348018786 0.37989267180286224 0.2054414422578255 395.4135676634935 630182.2518330897 0.07397889182009729 0.057038582234892665 5.670267945962057e-08 7.246396418231735 0.39694464684861663 YPIEHGIITNWDDMEK ddPTM_A459_Selumetinib_30min_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 ; 170.74 1.285e-05 814130000.0 14382.400000000001 15957.4 16371.0 18056.8 16302.2 15141.900000000001 13806.7 15509.9 9331.6 12640.400000000001 False True 14717.481936721244 14089.100189605997 14147.908119466087 14903.518848115351 14827.668888387174 14989.5862337452 12765.249503162064 15098.527068744566 15835.043646901895 14262.918467922644 1.0318702984821035 0.9878132740709719 0.9919364084766231 1.0449136957231733 1.039595712597997 1.050948041766966 0.8949956162107465 1.0585860883031204 1.11022464879926 1.0 13.79998159473932 -7.963444866041889 24.999867815331335 1.0648774089303479 1.0069645747503642 0.17299851568327818 0.04945187915748139 247.83595687056953 169493.54322461778 0.02674709783788481 0.012848801361561689 1.0878152276940536e-08 7.963444866041889 -0.05791283417998372 YPIEHGIITNWDDMEK ddPTM_A459_Selumetinib_30min_R2 4 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 ;;; 101.2 0.007874899999999999 78488100.0 276643.0 224743.0 265839.0 273812.0 295533.0 247233.0 230289.0 259847.0 189694.0 263593.0 False True 261268.28954967274 241980.06543735703 248735.2081636183 236518.33324795432 258405.50244145826 281287.1015922799 240997.89480899644 260603.1117500132 227638.1004932069 255982.38519313672 1.0206494847391465 0.9452996746427882 0.9716887666936517 0.9239633151691398 1.0094659530830346 1.0988533503195972 0.9414628066191563 1.0180509551600208 0.8892725189721774 1.0 17.96568501251815 -4.711895458506221 22.04126469033219 0.9799268012231609 1.0206522387124561 0.04972608673426926 0.05564976541297114 12363.529820266847 5498393.270185685 0.013879120166559863 8.389877188029292 1.9413531355025482e-05 4.711895458506221 0.040725437489295246 YPPS(ph)PAK ddPTM_A459_Selumetinib_30min_R1 2 YPPSPAK 7 0 P30838;A8MYB8;I3L3I9 P30838 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 1 YPPS(1)PAK;Y(0.005)PPS(0.995)PAK 99.688 0.021051 86576000.0 23452.0 25634.0 30383.0 30444.0 23840.0 23429.0 23459.0 23088.0 14787.2 21853.0 True False 23998.385970351712 22632.7593630767 26257.155481872695 25127.526904657723 21683.67620929385 23193.325531829967 21689.468743050737 22475.631239606617 25092.79838564314 24658.045416245805 0.9732476992900873 0.9178651016744922 1.0648514526854316 1.0190396878782049 0.8793753050275304 0.9405987027888749 0.8796102195821556 0.9114928154361611 1.0176312826932705 1.0 14.589770824868129 -6.246094040195946 24.931720371810155 0.930891333124414 0.9934091697036472 0.1920555906241601 0.05470679434781495 1234.280524796352 2005345.8194855063 0.016462972624100274 0.02118037045575634 5.674217251278313e-07 6.246094040195946 0.06251783657923327 YPPS(ph)PAK ddPTM_A459_Selumetinib_30min_R2 1 YPPSPAK 7 0 P30838;A8MYB8;I3L3I9 P30838 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring 1 Y(0.428)PPS(0.572)PAK 82.645 0.040774 8087200.0 61360.0 56583.0 56447.0 53564.0 50208.0 47317.0 51182.0 41987.0 35931.0 47088.0 True False 57949.85684354175 60922.73415697908 52815.261474846666 46268.49079694614 43900.42217478503 53834.48724903997 53562.064415208995 42109.175218677956 43118.203996022006 45728.44709068314 1.2672605463426865 1.3322720982885 1.1549760561540567 1.0118097976341085 0.9600243386294534 1.1772647153812572 1.171307311376465 0.9208529459828828 0.942918614981943 1.0 15.480804306509528 -5.500967351226437 3.2151782436715934 1.0331352910561353 1.2979073291642929 0.6288740109071053 0.0839209283466814 0.17336123423726096 3.6460132107056165 0.025541597944457255 0.05510678150300971 3.1552418147454243e-06 5.500967351226437 0.2647720381081575 YPPYTT(ph)PPR ddPTM_A459_Selumetinib_30min_R1 2 YPPYTTPPR 9 0 O43896 O43896 KIF1C Kinesin-like protein KIF1C 1 YPPYT(0.037)T(0.963)PPR;YPPYT(0.027)T(0.973)PPR 106.88 0.030195 65994000.0 5416.1 6062.1 6897.599999999999 7135.799999999999 7497.799999999999 5156.6 6357.700000000001 5923.5 2759.8 4992.7 True False 5542.284592103953 5352.346513806169 5960.94380580473 5889.666485555664 6819.625313844106 5104.729285818193 5878.133570386364 5766.389537760304 4683.179032183101 5633.561678016305 0.9837976237539849 0.9500821717622238 1.0581128150359937 1.0454605491475755 1.2105353067236566 0.9061282324711628 1.0434133690813123 1.0235779542917456 0.8312998596355381 1.0 12.459831603157983 -8.14985119197733 8.922708417228202 0.9160601009182744 1.0295768575984152 0.21815648322624726 0.08479325662201884 0.46311786229362073 33.21772930270919 0.057145879297544 0.02151097038313679 7.081883987096024e-09 8.14985119197733 0.11351675668014083 YPSSIS(ph)SSPQK ddPTM_A459_Selumetinib_30min_R1 1 YPSSISSSPQK 11 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 YPS(0.002)S(0.259)IS(0.356)S(0.231)S(0.152)PQK 94.82 0.021836 23474000.0 4949.9 7403.2 3292.8 3510.1 4461.1 4237.2 5988.6 5611.9 2734.2 6192.4 True False 5065.223039171243 6536.42990234569 2845.655846055701 2897.1269277374554 4057.594292671178 4194.577615069779 5536.875080550479 5463.054181979745 4639.737701933123 6987.254859083897 0.7249231839004864 0.9354789590718728 0.4072637829084135 0.4146302068788857 0.5807136528583948 0.6003183939421572 0.7924249497429126 0.7818598708872643 0.6640286915971235 1.0 12.77051004797922 -7.2623511816127095 22.988513497741625 0.7914000649149139 0.6058214020583553 0.2652276842281208 0.16103685614786814 44.60842086390157 1124614.4354497304 0.0696487968400174 0.05006439854785155 5.465738106040208e-08 7.2623511816127095 -0.18557866285655855 YPSSIS(ph)SSPQKDLTQAK ddPTM_A459_Selumetinib_30min_R1 1 YPSSISSSPQKDLTQAK 17 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 Y(0.001)PS(0.022)S(0.019)IS(0.319)S(0.319)S(0.319)PQKDLTQAK 60.032 0.033796 82934000.0 2337.3 2604.2 2590.4 3526.0 2389.1 2238.2 2661.7 2795.1 1408.2 2314.7 True False 2391.7545424058976 2299.2990533402663 2238.637908048679 2910.2502912174214 2173.0063268298627 2215.685740123002 2460.9258260530355 2720.964868235639 2389.61254914133 2611.814292087318 0.9157444882861284 0.8803455361685403 0.8571198629361958 1.11426386632244 0.8319911309977681 0.8483320375554968 0.9422284859641782 1.0417910938304462 0.9149243713003775 1.0 11.350836605202858 -7.527494061543507 24.865490580344225 0.9854166153357821 0.9090696519011022 0.1597227991592708 0.07978918727177521 242.07246400326414 1304157.9236202284 0.03776603683833656 0.021912482657114533 2.9682873309571985e-08 7.527494061543507 -0.07634696343467984 YPSSIS(ph)SSPQKDLTQAK ddPTM_A459_Selumetinib_30min_R2 2 YPSSISSSPQKDLTQAK 17 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 Y(0.001)PS(0.038)S(0.132)IS(0.584)S(0.123)S(0.123)PQKDLTQAK;YPS(0.008)S(0.026)IS(0.769)S(0.02)S(0.176)PQKDLTQAK 72.968 0.014405 264260000.0 180674.0 150919.0 165261.0 176825.0 159513.0 135733.0 136878.0 144719.0 122348.0 145069.0 True False 170632.86237532704 162494.0020189302 154628.28718257192 152741.1299598612 139473.5508756869 154428.98868850412 143243.09821861167 145140.1083304797 146821.018688745 140880.48103547213 1.2111888114036435 1.1534174274860405 1.0975848893051285 1.0841894408452701 0.9900133066735414 1.0961702256654038 1.0167703656729044 1.0302357520623107 1.0421672158528272 1.0 17.10411221479967 -4.741107235439958 0.6738409602435638 1.0281822805640013 1.3418374567161102 0.8179496517890391 0.028615698930800224 1.322608253136899 0.43758239216999123 0.012378026230383797 0.3237362906741398 1.8150674332999837e-05 4.741107235439958 0.3136551761521089 YPSSISS(ph)SPQK ddPTM_A459_Selumetinib_30min_R1 2 YPSSISSSPQK 11 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 YPS(0.001)S(0.016)IS(0.139)S(0.785)S(0.059)PQK;YPSSIS(0.001)S(0.499)S(0.499)PQK 189.24 1.9615e-05 41822000.0 10170.5 15611.8 7769.3 8208.5 8939.3 8989.9 13090.2 11983.2 5583.0 13204.7 True False 10407.452861651973 13783.963198271078 6714.271733710085 6775.0395676285325 8130.7418933616 8899.469768176108 12102.795675019512 11665.366609080658 9473.94323381341 14899.651869670106 0.6985030893800611 0.9251198161434808 0.4506327927954968 0.4547112662021236 0.545700125377602 0.5972938056554171 0.8122871447524284 0.7829288033787424 0.6358499726492719 1.0 13.86299100206454 -7.259214628562463 24.13870192148431 0.7896772219066593 0.6087293869888484 0.2831194274120389 0.15147179455418652 194.77871289462084 2113383.464732124 0.06400537766806735 0.04709009648855277 5.505355542027107e-08 7.259214628562463 -0.18094783491781097 YPSSISS(ph)SPQK ddPTM_A459_Selumetinib_30min_R2 1 YPSSISSSPQK 11 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 YPSSISS(0.5)S(0.5)PQK 201.38 1.8746e-05 95030000.0 72824.0 56180.0 64956.0 69634.0 77783.0 62991.0 87830.0 85710.0 72012.0 59792.0 True False 68776.73361756977 60488.82535282831 60776.801678745396 60149.72907464983 68011.20415115729 71667.43847463437 91914.2690318432 85959.40190994568 86416.41218339422 58065.64960172711 1.1844650682341469 1.0417316566286916 1.0466911520944673 1.035891779170946 1.1712812070070142 1.2342484578438728 1.582937066273849 1.4803830233458524 1.4882536021920925 1.0 15.825397327949878 -6.905565998166235 2.5763510542346224 1.426625509183312 1.0811805895320528 0.42867082471068263 0.1547211972580799 0.2232149615515572 3.0068697267857356 0.05825452317564506 0.049471267034593945 1.242893743412349e-07 6.905565998166235 -0.34544491965125923 YPSSISSS(ph)PQK ddPTM_A459_Selumetinib_30min_R1 1 YPSSISSSPQK 11 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 YPSSISS(0.075)S(0.925)PQK 182.41 3.6628e-05 18661000.0 2162.7 3541.3 1629.7 1235.2 1575.4 1796.4 1985.0 2080.3 1003.5 2170.7 True False 2213.0867021183535 3126.6829496942933 1408.395691301317 1019.4955075756548 1432.905348159461 1778.3298470006976 1835.2698518673324 2025.123686233267 1702.8662072598531 2449.3304894085354 0.9035476068616489 1.2765459635662826 0.5750125176620883 0.41623435954608257 0.5850191937575069 0.7260473238260832 0.7492944948848097 0.8268070376743214 0.6952374188062557 1.0 11.258171735273732 -5.268480762231738 24.99197031823011 0.6794414030851532 1.0900467913499534 0.4577327865469901 0.17042252572425134 414.9102050969071 1472644.2260138926 0.045407697032129046 0.09784806955759288 5.389137168890715e-06 5.268480762231738 0.4106053882648002 YPSSISSS(ph)PQK ddPTM_A459_Selumetinib_30min_R2 2 YPSSISSSPQK 11 0 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 YPSSISS(0.021)S(0.979)PQK;YPS(0.005)S(0.004)IS(0.041)S(0.029)S(0.921)PQK 212.68 1.9668e-05 127005000.0 108375.0 73852.0 87801.0 110579.0 109487.0 90726.0 124736.0 129324.0 106482.0 88397.0 True False 102351.95135949865 79516.21092839228 82151.97925050078 95517.94944058498 95732.26423380118 103222.6829713718 130536.47115969504 129700.31142925915 127781.37535566575 85844.74892701137 1.1922913473312429 0.9262792648622006 0.9569831617813882 1.1126824952542893 1.115179034598803 1.2024344442912385 1.5206110192096007 1.5108706478894303 1.4885170840712758 1.0 16.38944226766555 -6.953226857751312 2.4177681525735384 1.421113786630869 1.044624279572936 0.4576069890416532 0.15991341622000382 0.2261433797990713 2.675332802453414 0.06343918377730018 0.051966751534637715 1.1137126235017645e-07 6.953226857751312 -0.37648950705793305 YPSSISSS(ph)PQKDLTQAK ddPTM_A459_Selumetinib_30min_R1 1 YPSSISSSPQKDLTQAK 17 1 F8W726;Q14157-4;Q14157-1;Q14157-3;Q14157;Q14157-5 F8W726 UBAP2L Ubiquitin-associated protein 2-like 1 YPSSIS(0.022)S(0.138)S(0.84)PQKDLTQAK 85.23100000000002 0.006510800000000001 91496000.0 3397.2 3752.8 3983.4 3759.9 3412.7 3232.0 3845.8 3884.4 1999.5 3441.5 True False 3476.3481501995093 3313.4204313706136 3442.476159249964 3103.3040470642054 3104.0218875611204 3199.4890144212077 3555.7082097286566 3781.3730936905727 3393.0054622980324 3883.2500480487765 0.8952161481196083 0.8532596125339685 0.8864935599446425 0.7991512286527951 0.7993360842474729 0.8239204209960316 0.9156526532498981 0.97376502849478 0.8737540514556671 1.0 11.923048892105573 -7.395341905435703 4.319959352772996 0.9431249790007518 0.8416374210586367 0.567003412043271 0.04246000567938031 0.18330486898516163 5.573333478224996 0.0191518564760004 0.012472222119278427 4.0240011351886565e-08 7.395341905435703 -0.10148755794211506 YQASTSNTVS(ph)K ddPTM_A459_Selumetinib_30min_R1 1 YQASTSNTVSK 11 0 O95810 O95810 SDPR Serum deprivation-response protein 1 YQASTSNT(0.001)VS(0.999)K 78.342 0.031595 6636900.0 4001.2 4814.5 4397.4 4840.8 4366.6 3719.8 4169.6 3923.0 2472.0 3828.7 True False 4094.420175020096 4250.816101799673 3800.257233189186 3995.445153070133 3971.641800985845 3682.3821893081695 3855.0837150357825 3818.949296300105 4194.803452263435 4320.150939696165 0.947749333801762 0.983950829759349 0.8796584393082473 0.9248392495636117 0.9193294068714112 0.852373502849683 0.8923493111346961 0.8839851545947816 0.9709853916720916 1.0 12.076866003566336 -8.442266042351017 4.505198305557465 0.9993672089899809 0.9104022599097001 0.42860557192795534 0.03532646916721802 0.2012330212260484 6.9601070453912 0.03662885897939103 0.009568347724282123 3.611885361217246e-09 8.442266042351017 -0.08896494908028074 YQDEVFGGFVTEPQEES(ph)EEEVEEPEER ddPTM_A459_Selumetinib_30min_R1 13 YQDEVFGGFVTEPQEESEEEVEEPEER 27 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER 174.4 1.5740000000000004e-22 793572900.0 39550.55 46074.12000000001 45223.46000000001 47980.729999999996 45672.4 38735.83 44838.98000000001 39800.82000000001 23107.829999999998 35766.35 True False 40472.00086302637 40679.74061112274 39082.36252668433 39601.7962153501 41541.33948411712 38346.18271951963 41456.73963853008 38745.172962316356 39212.29978087238 40357.309416251446 1.0028419002265978 1.0079894125633027 0.968408526038812 0.9812793961780537 1.0293386770573183 0.9501669777836588 1.0272424063492178 0.9600534208733474 0.9716281969253882 1.0 15.300542374082356 YQDEVFGGFVTEPQEES(ph)EEEVEEPEER ddPTM_A459_Selumetinib_30min_R2 13 YQDEVFGGFVTEPQEESEEEVEEPEER 27 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER;YQDEVFGGFVTEPQEES(1)EEEVEEPEER 185.96 3.3435e-32 145237400.0 558005.5 597787.9 664953.5 694526.9 711078.9 549507.8 484680.2 547503.1 492891.4 613839.7 True False 526993.7881830016 643636.3097389468 622171.11575663 599931.1380942703 621746.8114559775 625197.5115148474 507218.78967559617 549096.2433769822 591483.4525363855 596116.552913922 0.8840448828454163 1.0797155465533375 1.0437071621570457 1.0063990593143268 1.0429953813843456 1.048784014566904 0.8508718424211205 0.9211222884063589 0.9922278615567893 1.0 19.185234908935392 -7.234477529626818 24.99638926289896 0.934482331310444 1.0222616077359732 0.26060133672839525 0.0624867993234306 890.4182090839768 825509.7582202184 0.023315893691437762 0.01805560898296859 5.828039282602574e-08 7.234477529626818 0.08777927642552918 YQEADS(ph)EEEEVVPR ddPTM_A459_Selumetinib_30min_R2 1 YQEADSEEEEVVPR 14 0 A0A669KB44;A0A669KAW0;A0A669KBE2;O60312 A0A669KB44 ATP10A Probable phospholipid-transporting ATPase VA 1 YQEADS(1)EEEEVVPR 126.91 0.0016563 0.0 8871.0 7501.7 8816.7 8993.2 8236.8 5565.3 7501.3 6302.3 5416.9 5835.4 True False 8377.98533342665 8077.056268232679 8249.443120897144 7768.310645864679 7202.019546073719 6331.869558236623 7850.125313543958 6320.638649598068 6500.431360831917 5666.916839809981 1.4784027311944063 1.4252999464349847 1.4557198127463185 1.3708178301280949 1.2708885183349914 1.1173394170451492 1.3852550752813206 1.1153575794858508 1.1470843043198575 1.0 12.468348316177105 -5.703412927340708 0.19083218472503186 0.9408628678221234 1.8167568265206464 0.7752336258747073 0.07648678336062958 5.021447191830986 0.2594821628788377 0.2263548464197056 1.1038994173628744 1.9796438846243226e-06 5.703412927340708 0.875893958698523 YQEDS(ph)DPERS(ph)DYEEQQLQK ddPTM_A459_Selumetinib_30min_R2 1 YQEDSDPERSDYEEQQLQK 19 1 Q6P6C2-3;Q6P6C2;Q6P6C2-1 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 2 Y(0.12)QEDS(0.879)DPERS(0.895)DY(0.105)EEQQLQK 89.98200000000001 0.0055114 3434400.0 20497.0 15911.0 20703.0 23516.0 22044.0 21632.0 23899.0 21581.0 24230.0 17941.0 True False 19357.8587959921 17131.3225380714 19370.991519722058 20313.080232637305 19274.635644139606 24611.611644255387 25010.350854970104 21643.797137073132 29076.677042765685 17422.99671368387 1.1110521980864867 0.9832592417707687 1.111805956119377 1.1658775219009017 1.1062755713545807 1.4125934848467048 1.4354792844176565 1.2422545611843157 1.668867733868601 1.0 14.088705164918315 -6.754511876071217 23.943906618958334 1.3722074539605469 1.0942084629895807 0.37738812009730494 0.16347874891301312 91.73718594908273 317075.19268800935 0.051178881399628 0.05004631948826379 1.7599005374937136e-07 6.754511876071217 -0.27799899097096614 YQEDS(ph)DPERSDYEEQQLQK ddPTM_A459_Selumetinib_30min_R2 2 YQEDSDPERSDYEEQQLQK 19 1 Q6P6C2-3;Q6P6C2;Q6P6C2-1 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 Y(0.045)QEDS(0.947)DPERS(0.008)DYEEQQLQK;Y(0.095)QEDS(0.898)DPERS(0.006)DY(0.001)EEQQLQK 59.9 0.022626 30355600.0 44910.6 31857.8 35071.9 47405.4 42439.0 25716.9 32670.1 43717.5 33409.9 28618.3 True False 42414.648643376284 34301.19082102766 32815.41213739749 40948.70274112368 37107.433410526246 29259.169540225193 34189.32438457501 43844.71068717825 40092.81355060243 27792.015319726823 1.5261451231739316 1.2342102732175961 1.1807496419342087 1.4733981062560157 1.3351832525864837 1.0527904940904729 1.230185144591057 1.577600982972156 1.4426018800495002 1.0 14.762382833963985 -4.751952512783349 24.492049395408912 1.2946895922990869 1.5261457212248208 0.1481182759703935 0.17368114649942043 646.3458315748559 1668502.4476116244 0.04441458068549107 0.5478381341903029 1.7703025185555464e-05 4.751952512783349 0.23145612892573397 YQEDSDPERS(ph)DYEEQQLQKEEEAR ddPTM_A459_Selumetinib_30min_R2 1 YQEDSDPERSDYEEQQLQKEEEAR 24 2 Q6P6C2-3;Q6P6C2;Q6P6C2-1 Q6P6C2-3 ALKBH5 RNA demethylase ALKBH5 1 Y(0.004)QEDS(0.067)DPERS(0.738)DY(0.191)EEQQLQKEEEAR 50.202 0.01581 20385000.0 33887.0 50441.0 49669.0 50119.0 51431.0 31228.0 29104.0 28139.0 21454.0 46895.0 True False 32003.696200409064 54309.66250662176 46473.35061551831 43292.705739902616 44969.77798102631 35529.373540440436 30457.393668481913 28220.879831337763 25745.39947484502 45541.01950215736 0.7027443950588983 1.1925438450943993 1.0204723373247448 0.9506310182153863 0.9874565495595902 0.780162015010607 0.6687903345474971 0.6196804581856339 0.5653233009776036 1.0 15.474878968218608 -6.886156898594464 2.9153746963423766 0.6835079462190294 0.9870795412287097 0.3749138488789493 0.15641361415721283 0.23944517369310203 4.097859650562144 0.05760449538872891 0.04988406333011045 1.299699947532659e-07 6.886156898594464 0.30357159500968023 YQEQGGEAS(ph)PQR ddPTM_A459_Selumetinib_30min_R1 2 YQEQGGEASPQR 12 0 H0Y5J4;Q9UJU6-5;Q9UJU6 H0Y5J4 DBNL Drebrin-like protein 1 YQEQGGEAS(1)PQR;YQEQGGEAS(1)PQR 159.58 0.0004647 50288000.0 3467.8999999999996 4149.8 3066.4 3379.6 3843.2000000000003 2982.6 3785.3 3427.2 1929.6399999999999 2799.8 True False 3548.6953226412543 3663.939486810318 2649.9997225295215 2789.416302949062 3495.5832385720687 2952.597751984125 3499.7717734374855 3336.299522885473 3274.4581446705547 3159.18160236146 1.123295767482514 1.1597748872909224 0.8388247514953462 0.8829553517480597 1.1064837918653208 0.9346084282641696 1.1078096209541854 1.0560644948019509 1.0364893687095817 1.0 11.6253351559969 YQEQGGEAS(ph)PQR ddPTM_A459_Selumetinib_30min_R2 2 YQEQGGEASPQR 12 0 H0Y5J4;Q9UJU6-5;Q9UJU6 H0Y5J4 DBNL Drebrin-like protein 1 YQEQGGEAS(1)PQR;YQEQGGEAS(1)PQR 119.62 0.0042332 109242000.0 25951.0 34963.0 31048.0 35955.0 40109.0 28883.0 26616.0 28697.0 25077.0 31846.0 True False 24508.74731008397 37644.549676235976 29050.40548250644 31057.86697416546 35070.14884099053 32861.37107623101 27853.696738603445 28780.503518955906 30093.10070992303 30926.5232341551 0.7924831098704502 1.2172254020025606 0.9393362862859189 1.004246961063677 1.1339829108969879 1.0625627338523158 0.9006410622918634 0.9306090859631728 0.973051528685525 1.0 14.916557034031358 -7.255079005119735 24.824636160853455 0.9452928427546579 1.0338319903851616 0.09541781476745592 0.1088648777885306 958.5875964772283 3741388.0347424513 0.040269123199061 0.03039709688809714 5.5580313858327135e-08 7.255079005119735 0.08853914763050375 YQEQGGEAS(ph)PQRTWEQQQEVVSR ddPTM_A459_Selumetinib_30min_R1 1 YQEQGGEASPQRTWEQQQEVVSR 23 1 H0Y5J4;Q9UJU6-5;Q9UJU6 H0Y5J4 DBNL Drebrin-like protein 1 Y(0.018)QEQGGEAS(0.956)PQRT(0.025)WEQQQEVVSR 68.705 0.0017027 9960400.0 462.92 517.17 1142.8 1004.5 584.01 603.25 459.97 579.35 160.01 378.29 True False 473.70513531448137 456.61949597418953 987.6140369510617 829.0829318003115 531.1863986153402 597.1818527071756 425.2740925760284 563.9837560059816 271.5252833319872 426.8472063566386 1.1097768200424676 1.0697492900836176 2.3137413628189294 1.9423412393323658 1.2444415488841791 1.3990529721499907 0.9963145740274664 1.3212778427669103 0.6361182158121539 1.0 8.737575926880233 -7.091261943727874 1.3426517290406343 0.969954592597072 1.5928627900709706 0.3218318624525476 0.38323569868120805 0.5863729277187324 2.1193432906198546 0.2338346905401379 0.15756358851667632 8.104720760173143e-08 7.091261943727874 0.6229081974738987 YQEQGGEAS(ph)PQSR ddPTM_A459_Selumetinib_30min_R1 1 YQEQGGEASPQSR 13 0 B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 B4DDD6 DBNL Drebrin-like protein 1 YQEQGGEAS(0.979)PQS(0.021)R 177.63 0.00010452 7662000.0 1003.9 1031.4 1104.8 1183.6 1286.6 916.41 991.77 921.88 425.98 984.21 True False 1027.2889167506432 910.6432085151482 954.774228232003 976.906478923693 1170.2272571676785 907.1917474337063 916.9599904213925 897.4287477117357 722.8569476517712 1110.542940517241 0.9250330439921379 0.8199981966397548 0.8597364346733968 0.8796656511712134 1.0537433668459855 0.816890292428654 0.8256862089405689 0.8080990972701638 0.6509040949961798 1.0 10.117049462214764 -6.961703440400508 24.999913590702654 0.8074812761839844 0.9022282255062855 0.16139497552893156 0.0971930920792496 281.6131185264147 183835.62968026986 0.033792146974413205 0.029801821996590518 1.092185885056338e-07 6.961703440400508 0.0947469493223011 YQEQGGEAS(ph)PQSR ddPTM_A459_Selumetinib_30min_R2 1 YQEQGGEASPQSR 13 0 B4DDD6;Q9UJU6-4;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 B4DDD6 DBNL Drebrin-like protein 1 YQEQGGEAS(0.5)PQS(0.5)R 75.764 0.046485000000000005 25135000.0 14310.0 11707.0 13703.0 14782.0 14390.0 13127.0 11818.0 10357.0 9154.2 14010.0 True False 13514.707487468759 12604.889256061953 12821.363898698328 12768.666099627693 12582.199551767771 14935.125094958417 12367.560416922744 10387.13715530635 10985.295789718757 13605.494897648465 0.9933271512089282 0.9264557703256018 0.9423665949052935 0.9384933216824471 0.9247880835222277 1.0977274408106803 0.9090121682424297 0.7634516225574149 0.807416111825335 1.0 13.731901814887314 -7.526291104886174 24.84696776455494 0.8385066627982444 0.967013269931481 0.3130580089215177 0.07436888958564486 100.55164661084763 732138.9734924119 0.03378137032838558 0.01963066767045977 2.9765206173834416e-08 7.526291104886174 0.12850660713323658 YQEQGGEASPQRT(ph)WEQQQEVVSR ddPTM_A459_Selumetinib_30min_R1 1 YQEQGGEASPQRTWEQQQEVVSR 23 1 H0Y5J4;Q9UJU6-5;Q9UJU6 H0Y5J4 DBNL Drebrin-like protein 1 Y(0.002)QEQGGEAS(0.106)PQRT(0.891)WEQQQEVVSR 61.903 0.01167 8299200.0 364.39 448.88 942.45 987.68 811.99 549.12 569.65 429.9 332.97 362.06 True False 372.8795780204872 396.32492092134936 814.4704665072873 815.2002290498081 738.5456478684786 543.5963513610685 526.6808418721541 418.49765548799735 565.0257708333968 408.533927763051 0.9127260985696071 0.970115072428494 1.9936421705951404 1.9954284666477513 1.8077951368994591 1.3306027098839965 1.289197312830351 1.0243889847276657 1.3830571525043835 1.0 8.674312085484639 -7.101774720758783 3.00615009907599 1.1728944686953457 1.5548989114033092 0.1753804856952853 0.3638417228958233 0.5302536492575678 9.20201184234196 0.169707035464502 0.12886766277088485 7.91088878867136e-08 7.101774720758783 0.3820044427079634 YQES(ph)PGIQMK ddPTM_A459_Selumetinib_30min_R1 2 YQESPGIQMK 10 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 Y(0.242)QES(0.758)PGIQMK;Y(0.006)QES(0.994)PGIQMK 122.46 0.0044582 48297000.0 7203.2 8086.9 5988.1 6889.7 6218.2 5489.6 6242.0 5858.3 3179.6 5525.4 True False 7371.020545012689 7140.081988502182 5174.948910278839 5686.543230686518 5655.764907912378 5434.379608157997 5771.160914536972 5702.918853559751 5395.548971204214 6234.638911953715 1.18226903740651 1.1452278294437317 0.8300318564330766 0.9120886246970406 0.9071519598462296 0.8716430389799519 0.925660811482103 0.9147151798359174 0.8654148295355631 1.0 12.606090291386014 -5.223456365460483 8.492005435285526 0.9004421737755538 1.1650635737961528 0.8534443266318706 0.04315357761061712 0.11022509706861529 22.832807325274015 0.010191482738122733 0.02680122889163765 5.977831022790472e-06 5.223456365460483 0.264621400020599 YQES(ph)PGIQMK ddPTM_A459_Selumetinib_30min_R2 5 YQESPGIQMK 10 0 Q9UHI6;E9PJ60 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 1 YQES(1)PGIQMK;Y(0.025)QES(0.975)PGIQMK;YQES(1)PGIQMK;Y(0.003)QES(0.997)PGIQMK;Y(0.001)QES(0.999)PGIQMK 143.76 0.0010552 93076800.0 298119.0 252794.4 295784.5 336086.3 329694.0 297238.0 302250.0 299522.0 246138.9 275229.7 True False 281550.73944491264 272182.91761788935 276754.0472958142 290310.76615879446 288274.8922182434 338179.8364420854 316305.2238970129 300393.55943146383 295373.5576954842 267283.1034283593 1.053380239280174 1.0183319264356092 1.0354341286298085 1.0861545770573084 1.0785376573402088 1.265249587812904 1.183408976623893 1.1238778492856702 1.1050962590108284 1.0 18.028009113474617 -6.254428664641586 2.2587136619618056 1.1456628534602924 1.0383032319121392 0.2620937725383168 0.06557239353752155 0.3616485894635918 3.6260554177329536 0.0220368496075092 0.028383036472920658 5.566360574132256e-07 6.254428664641586 -0.10735962154815315 YQPLAS(ph)TASDNDFVTPEPR ddPTM_A459_Selumetinib_30min_R1 1 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLAS(0.419)T(0.419)AS(0.161)DNDFVTPEPR 253.09 5.8746e-38 49978000.0 3640.0 4050.5 4379.3 4529.5 4351.1 3385.9 4062.3 3840.4 1989.6 3081.4 True False 3724.804917792948 3576.265576973639 3784.6151137730003 3738.5078542454075 3957.543773249098 3351.8409201512254 3755.8774404235064 3738.5401166227166 3376.205885365426 3476.9277053777396 1.071292023711571 1.0285705887534717 1.088494048328748 1.0752331285068377 1.138230100996346 0.9640237601049215 1.0802287992972408 1.075242407496809 0.9710313735150352 1.0 11.763597354552667 -8.259739844137144 24.996364887612827 0.9855156804921568 1.0646241678358064 0.35620887435011817 0.04282611456037111 156.36922956477014 2299947.088997517 0.03208772022535371 0.010696125865569636 5.498701645010509e-09 8.259739844137144 0.07910848734364961 YQPLAS(ph)TASDNDFVTPEPR ddPTM_A459_Selumetinib_30min_R2 1 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLAS(0.406)T(0.406)AS(0.188)DNDFVTPEPR 101.72 0.0011557 5411100.0 13262.0 11134.0 14331.0 16987.0 16209.0 10138.0 11870.0 12088.0 10729.0 16189.0 True False 12524.95113199236 11987.941998547354 13408.959062413025 14673.34129579053 14172.680509701455 11534.41747639891 12421.97851995879 12123.174078723865 12875.099793307176 15721.581505926546 0.7966724675422027 0.7625150175908367 0.8529014118177783 0.9333247606329641 0.9014793139200911 0.7336677593186661 0.7901227058662064 0.7711167018504981 0.8189443147595339 1.0 13.940458731751164 -11.725007723556693 2.2147315729457087 1.5089580993543157 0.8184517911148131 0.4595402697761787 0.059254644873200576 4112897.600309375 720437.138661647 10508797.524311863 0.017670663377358706 1.8836155906962997e-12 11.725007723556693 -0.6905063082395025 YQPLAST(ph)ASDNDFVTPEPR ddPTM_A459_Selumetinib_30min_R1 2 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLAS(0.003)T(0.996)AS(0.001)DNDFVTPEPR;YQPLAS(0.008)T(0.583)AS(0.408)DNDFVTPEPR 255.72 2.9182e-38 12982700.0 2838.4 3293.3399999999997 3740.46 4422.299999999999 3616.2200000000003 3209.0499999999997 3315.79 3328.17 1729.6999999999998 2893.9300000000003 True False 2904.5291974350303 2907.75422176777 3232.5260768760686 3650.028321852182 3289.133539495498 3176.7698705842713 3065.677290742155 3239.8961201802463 2935.1745677103827 3265.3941047653025 0.8894880998273227 0.8904757369177533 0.9899344376713156 1.1177910551518329 1.0072700059988324 0.9728595595699463 0.9388383736800119 0.9921914526188903 0.8988729916021411 1.0 11.6730414077288 -5.263170389562296 8.046990171613947 0.9922833860352909 0.8897222092005652 0.36172784988623163 0.05291302865319942 0.1204589137292794 89.23002801197376 0.014822946770406204 0.034499909167978064 5.455437823788688e-06 5.263170389562296 -0.10256117683472565 YQPLAST(ph)ASDNDFVTPEPR ddPTM_A459_Selumetinib_30min_R2 2 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLAS(0.023)T(0.823)AS(0.154)DNDFVTPEPR;YQPLAS(0.141)T(0.596)AS(0.263)DNDFVTPEPR 233.31 1.3234e-23 57253000.0 42698.0 34910.0 42015.0 45851.0 50388.0 35002.0 34552.0 39522.0 30294.0 44291.0 True False 40325.0160936367 37587.48474665783 39311.800642473194 39606.01470261328 44057.808965564596 39823.20778347946 36158.73646348911 39637.002476780704 36353.646485082274 43012.2037481619 0.9375249947605852 0.8738795381593092 0.9139685302488869 0.9208087763767702 1.0243095011714527 0.9258583451488761 0.840662261231717 0.9215292178205254 0.8451937663537137 1.0 15.392458429806572 -10.336066185538762 18.08190277808903 0.9999999999839012 0.9127123811880452 0.2219940101241744 0.0496439707473447 0.0 0.0 0.050192205419646245 0.012173397913405925 4.6124727611760486e-11 10.336066185538762 -0.087287618795856 YQPLASTAS(ph)DNDFVTPEPR ddPTM_A459_Selumetinib_30min_R1 1 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLAS(0.001)T(0.08)AS(0.919)DNDFVTPEPR 229.46 1.3259e-23 55342000.0 858.68 1008.8 1065.5 1049.9 972.37 874.77 985.65 911.58 422.1 720.48 True False 878.685573299574 890.6892270216038 920.8109523725554 866.5546740638604 884.4193051858665 865.9706080276113 911.301626948632 887.4019371708504 716.2728710357587 812.9606260694994 1.080846408943372 1.0956117657603006 1.1326636528813094 1.0659245309990932 1.0878993112641326 1.0652060877959175 1.1209664991459567 1.091568162976428 0.8810671120676453 1.0 9.667041670057989 -8.246543657197483 24.666338712642514 0.9405335660196373 1.0930110457967133 0.7689270599530491 0.03334082150895135 241.19482767100527 399404.76200361265 0.02117066425871472 0.007926956750185659 5.668345879453912e-09 8.246543657197483 0.15247747977707593 YQPLASTAS(ph)DNDFVTPEPR ddPTM_A459_Selumetinib_30min_R2 1 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLAS(0.275)T(0.045)AS(0.68)DNDFVTPEPR 133.35 0.00022849 5306600.0 25450.0 21219.0 28589.0 28899.0 31199.0 24423.0 20808.0 25015.0 21666.0 30847.0 True False 24035.59088442208 22846.429070161343 26749.614865349668 24962.90634644437 27279.502697401156 27787.046560079943 21775.613230269777 25087.789508543818 25999.80539861994 29956.366959868825 0.8023533333204744 0.7626568702662663 0.8929525700224231 0.833308871529249 0.9106412247501928 0.9275839956595865 0.7269110189310196 0.8374777068979287 0.8679225165538496 1.0 14.870575047177942 YQPLASTASDNDFVT(ph)PEPR ddPTM_A459_Selumetinib_30min_R1 3 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLASTASDNDFVT(1)PEPR;YQPLASTAS(0.001)DNDFVT(0.999)PEPR;YQPLASTASDNDFVT(1)PEPR 303.05 4.248899999999998e-100 34696000.0 4215.23 5077.5 5292.2 5631.5 5035.700000000001 4217.31 4687.66 4221.4400000000005 2471.33 4265.3 True False 4313.436657590213 4483.023939534292 4573.54830797376 4648.0642413473915 4580.221824125043 4174.887690411105 4334.066032143281 4109.473698030361 4193.666511198299 4812.792802540301 0.89624399689791 0.9314807687478363 0.9502898827391317 0.9657727710393097 0.9516765030290726 0.8674563526207704 0.9005303593904277 0.8538646616703067 0.8713582078548628 1.0 12.232658599263019 -6.75365529614346 24.991635220172974 0.8896264842677631 0.9407741823919892 0.1749427902374956 0.04160409488275189 238.12251017029138 764516.7681911218 0.013350897660818161 0.013114422016615885 1.7633750994994458e-07 6.75365529614346 0.05114769812422604 YQPLASTASDNDFVT(ph)PEPR ddPTM_A459_Selumetinib_30min_R2 4 YQPLASTASDNDFVTPEPR 19 0 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 YQPLASTASDNDFVT(1)PEPR;YQPLASTAS(0.007)DNDFVT(0.993)PEPR;YQPLASTAS(0.002)DNDFVT(0.998)PEPR;YQPLASTASDNDFVT(1)PEPR 287.75 6.421699999999998e-85 27498700.0 125323.0 122521.0 135614.0 153293.0 174281.0 137216.0 121513.0 120048.0 112125.0 158063.0 True False 118358.04936771824 131917.9667328918 126888.7428853587 132414.2289548251 152386.26268809172 156116.25847717052 127163.59527344152 120397.31980498362 134553.1330342592 153499.3104930053 0.7710656744162484 0.8594042951020492 0.8266404746563393 0.8626372882688552 0.9927488416635963 1.0170485976501142 0.8284310520029088 0.7843508835205479 0.876571579390844 1.0 17.227872649572618 -6.008237777574951 12.182117017199406 0.9083038385500798 0.8266412319960322 0.25767477965099506 0.07367332496191675 0.9298586837263112 1368.2868693381295 0.02353261592528795 0.03272603814799803 9.81210580095579e-07 6.008237777574951 -0.08166260655404756 YQQETSVSQLPGRPKS(ph)PLSK ddPTM_A459_Selumetinib_30min_R1 2 YQQETSVSQLPGRPKSPLSK 20 2 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 YQQETSVS(0.001)QLPGRPKS(0.918)PLS(0.081)K;YQQETSVSQLPGRPKS(0.925)PLS(0.075)K 107.95 0.00049245 71829000.0 3297.1000000000004 2680.97 4904.5 5551.4 3948.94 3600.5 3059.25 2788.59 1855.79 2433.51 True False 3373.9160149602 2367.08078605086 4238.495838490095 4581.952202684174 3591.7590742419834 3564.2822389924363 2828.4883094836955 2714.6275345831027 3149.1400884611476 2745.874712894718 1.2287217618182575 0.8620498141939873 1.5435867552827442 1.6686676129712605 1.3080564300239064 1.2980498426437483 1.0300864406525985 0.9886203189952996 1.1468622634793504 1.0 11.423050085234859 -7.233341572498728 5.1003765810002895 1.0393115445373209 1.3250537898938157 0.3118754227967898 0.20146616417114613 0.27000344779526825 19.922353962278542 0.08933384830293963 0.0661587708844757 5.8433032771601144e-08 7.233341572498728 0.28574224535649484 YQQETSVSQLPGRPKS(ph)PLSK ddPTM_A459_Selumetinib_30min_R2 3 YQQETSVSQLPGRPKSPLSK 20 2 Q9HCD6;Q9HCD6-2 Q9HCD6 TANC2 Protein TANC2 1 YQQETSVSQLPGRPKS(0.812)PLS(0.188)K;YQQETSVSQLPGRPKS(0.827)PLS(0.173)K;YQQETSVSQLPGRPKS(0.853)PLS(0.147)K 82.367 0.0013050999999999998 105194000.0 213700.0 215190.0 250839.0 233580.0 207634.0 117910.7 103997.4 97358.6 92962.4 204920.0 True False 201823.4095088801 231694.3810550931 234700.2918328533 201766.0010520252 181549.16064848832 134151.82863823522 108833.48516693863 97641.89740741614 111557.47758647929 199003.4271538991 1.0141705215599135 1.1642733211620144 1.1793781403138754 1.0138820418202632 0.9122916285662129 0.674118182570238 0.5468925169955609 0.4906543510524815 0.5605806853778775 1.0 17.60243375091106 -6.566929637188028 1.7617364657860737 0.6041873719277225 1.1145567838466395 0.681968714714063 0.14074095196188954 0.1814873815538173 1.1473529680309562 0.05283032671590756 0.055787153191181056 2.710630762851465e-07 6.566929637188028 0.5103694119189169 YQQGDFGYCPR ddPTM_A459_Selumetinib_30min_R2 2 YQQGDFGYCPR 11 0 Q5SRQ6;P67870;Q5SRQ3;N0E472;A0A0G2JM12 Q5SRQ6 CSNK2B;CSNK2B-LY6G5B-1181;CSNK2B-LY6G5B--991 Casein kinase II subunit beta 0 ; 192.12 0.00027829 5443700.0 20340.5 19182.300000000003 19284.7 17852.1 21125.7 15599.3 15880.8 15473.300000000001 15816.0 17581.9 False True 19210.056439472977 20653.520729184034 18043.94339759378 15420.61318340978 18471.70069984577 17747.96197865353 16619.288667208202 15518.324741257296 18979.64193596293 17074.26486373773 1.125088347450392 1.2096286952329007 1.056791817486412 0.9031494653781568 1.0818445682587428 1.0394568738561971 0.9733531018664349 0.9088722041682196 1.1115935056314976 1.0 14.059535843846875 -5.446632891184904 5.09899468419277 1.0008178657722209 1.1639517905688546 0.49633161692394434 0.06547982703291917 0.16801918709650984 7.801815993403548 0.017018678601581464 0.03599886707077463 3.5757496830383188e-06 5.446632891184904 0.1631339247966337 YQQIT(ph)PVNQSR ddPTM_A459_Selumetinib_30min_R1 1 YQQITPVNQSR 11 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 Y(0.002)QQIT(0.998)PVNQSR 125.84 0.007654300000000002 7308700.0 2182.6 2641.3 2526.2 2752.6 2619.0 1988.5 2387.8 1854.4 1248.5 2036.2 True False 2233.450333399697 2332.0553680929443 2183.1559154233214 2271.910082701382 2382.1119124220063 1968.4974954135412 2207.6863235711903 1805.2152880598812 2118.6133131678394 2297.5661042675915 0.9720940473709098 1.0150112172012336 0.9502037444616892 0.9888333913359207 1.0367979872254278 0.8567751290189974 0.9608804375510872 0.7857076602526482 0.9221120163779584 1.0 11.165890655176215 -6.764016611910561 24.999805817997828 0.8951883619817727 0.9912705298296789 0.3528477241373198 0.05846704801512591 68.80002085682128 667371.5976524494 0.01913191204106061 0.017654268483827455 1.721802714191276e-07 6.764016611910561 0.09608216784790624 YQQIT(ph)PVNQSR ddPTM_A459_Selumetinib_30min_R2 1 YQQITPVNQSR 11 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 Y(0.061)QQIT(0.939)PVNQSR 118.73 0.012218 5761200.0 24955.0 25060.0 22489.0 22929.0 27454.0 23774.0 23170.0 22894.0 18125.0 20758.0 True False 23568.101002780066 26982.02141939975 21042.082224171838 19806.030645268795 24004.983078125962 27048.652701115392 24247.450910484007 22960.61774969427 21750.506454813367 20158.66260423889 1.169130188121917 1.3384827133187926 1.0438233248542583 0.9825071749107035 1.1908023636983875 1.3417880556931243 1.202830335847049 1.1389950911161237 1.0789657469756824 1.0 14.299112308157408 -8.39614888533579 1.9901459254013871 1.0035405272106808 1.1800286318103919 0.2348133886070376 0.10500946352041939 0.5138629474085445 4.184526754096315 0.10934287185353926 0.03105823699513295 4.016530920669987e-09 8.39614888533579 0.1764881045997111 YQQITPVNQS(ph)R ddPTM_A459_Selumetinib_30min_R2 2 YQQITPVNQSR 11 0 Q9NYL2 Q9NYL2 ZAK Mitogen-activated protein kinase kinase kinase MLT 1 YQQITPVNQS(1)R;YQQITPVNQS(1)R 149.82 0.00062438 39015000.0 99763.0 70550.0 89265.0 92012.0 92836.0 83461.0 65962.0 73740.0 44289.0 81279.0 True False 94218.5718429311 75960.95814599561 83521.78708438325 79479.80687044661 81173.11171562987 94956.99516647552 69029.36370122345 73954.5711916859 53148.037538054035 78932.26408179657 1.193663617013361 0.9623562560840542 1.058145082444748 1.0069368691626865 1.0283895015542837 1.203018768954514 0.8745392584924352 0.9369371581061916 0.6733372994720809 1.0 16.26832751142655 -7.363116359613398 8.61083253086811 0.8645571927985966 1.0641059677993059 0.47146246336337916 0.10545525573116958 0.3026317793809053 23.376780190499897 0.042465755045401093 0.028562997330993538 4.333947442818626e-08 7.363116359613398 0.19954877500070933 YQT(ph)QPVTLGEVEQVQSGK ddPTM_A459_Selumetinib_30min_R1 2 YQTQPVTLGEVEQVQSGK 18 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 YQT(0.985)QPVT(0.008)LGEVEQVQS(0.007)GK;YQT(0.973)QPVT(0.027)LGEVEQVQSGK 211.11 2.3532e-11 22728000.0 17295.9 8151.3 12739.5 10713.8 8509.2 12075.4 7490.7 10615.7 12227.0 7370.200000000001 True False 17698.860818037105 7196.94200656344 11009.54587306445 8842.835952933974 7739.544362421274 11953.932439585966 6925.670468202835 10334.137151346671 20748.325975252847 8316.236961827432 2.128229498423036 0.8654084821774927 1.32386149211472 1.063321787669555 0.9306546215489953 1.4374208544629032 0.8327889765518381 1.2426458263252542 2.4949176016135977 1.0 13.021715151418105 -8.042126291900047 24.982846228333432 1.7879002314431947 1.1943268969728156 0.1497342107499714 0.48931489737610107 745.9992090969995 442407.7788078302 0.3028724432223996 0.11449883153354098 9.075565763035487e-09 8.042126291900047 -0.5935733344703791 YQT(ph)QPVTLGEVEQVQSGK ddPTM_A459_Selumetinib_30min_R2 1 YQTQPVTLGEVEQVQSGK 18 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 YQT(0.981)QPVT(0.019)LGEVEQVQSGK 235.21 2.9007e-19 5890800.0 33402.0 18562.0 26551.0 33405.0 19311.0 33577.0 16122.0 16235.0 14086.0 16745.0 True False 31545.65055880024 19985.64571376289 24842.73756654304 28855.181373160813 16884.979537469608 38201.92696834151 16871.70494513694 16282.241162151066 16903.5935957242 16261.52834126506 1.9398945718251077 1.2290139828399496 1.5277000442512163 1.7744446135446106 1.0383390283570386 2.3492211904462112 1.0375227094936397 1.001273731499975 1.0394836967955738 1.0 13.989175235163211 -7.465951815965416 24.998905731450005 1.016103224131528 1.6055036731453454 0.4428093592985072 0.34117056737744245 261.9852859327273 115048.37600752462 0.13486954885878066 0.09092866893366243 3.4201738649895876e-08 7.465951815965416 0.5894004490138174 YQTQPVT(ph)LGEVEQVQSGK ddPTM_A459_Selumetinib_30min_R2 1 YQTQPVTLGEVEQVQSGK 18 0 O95425-3;O95425;A0A6I8PIX7;O95425-4 O95425-3;O95425-4 SVIL Supervillin 1 YQT(0.018)QPVT(0.859)LGEVEQVQS(0.123)GK 148.19 0.00046938 4325200.0 37160.0 18648.0 25344.0 31711.0 15050.0 33164.0 18645.0 13462.0 12136.0 13442.0 True False 35094.795963266166 20078.24163722931 23713.39463246081 27391.907095473787 13159.284451292913 37732.03996718222 19512.029444366606 13501.17219124592 14563.539108171859 13053.894533489693 2.6884540757726105 1.5381035587286762 1.8165762387327575 2.0983704920550723 1.008073446398149 2.8904814475389613 1.4947285956929255 1.0342639245788863 1.1156470638558618 1.0 13.67219266802516 -7.518251987487586 14.06389165733924 1.0977531027335665 1.956936916681467 0.42079578586187094 0.5035869012883286 0.74210445488328 2260.4487329166086 0.2186578572714042 0.13320867187719085 3.0321313624581185e-08 7.518251987487586 0.8591838139479004 YQVS(ph)DGSLTVTSVSR ddPTM_A459_Selumetinib_30min_R1 1 YQVSDGSLTVTSVSR 15 0 H0YDP1;Q9UPX0;Q9UPX0-2 H0YDP1 IGSF9B Protein turtle homolog B 1 YQVS(0.433)DGS(0.433)LT(0.107)VT(0.027)SVSR 108.97 0.0038616 30768000.0 143.59 185.15 143.71 174.78 266.17 253.93 154.09 176.2 0.0 150.38 True False 146.93536762249715 163.47255192610018 124.19497134252462 144.2579540269373 242.09497049613032 251.3756947499928 142.4668672414293 171.52660362173793 0.0 169.68273782524332 0.8659417540388007 0.9634011922559911 0.7319246078551216 0.8501628148852062 1.4267507325669422 1.4814453018131122 0.8396073110757812 1.0108665490675524 0.0 1.0 7.40669599377938 -8.110970597024343 13.281362510827847 0.5000624418284987 1.0279306900152532 0.2928098360028796 0.324010171547776 1.090557324644326 126.14088789498979 0.22153347582311517 0.08371141200932317 7.745142328510897e-09 8.110970597024343 0.5278682481867545 YQVSDGS(ph)LTVTSVSR ddPTM_A459_Selumetinib_30min_R1 2 YQVSDGSLTVTSVSR 15 0 H0YDP1;Q9UPX0;Q9UPX0-2 H0YDP1 IGSF9B Protein turtle homolog B 1 YQVS(0.253)DGS(0.371)LT(0.371)VT(0.005)SVSR;YQVS(0.02)DGS(0.963)LT(0.007)VT(0.007)S(0.002)VSR 116.79 0.0022169 140221000.0 504.06 929.8299999999999 708.82 850.21 533.83 615.25 486.31 866.46 388.2 609.18 True False 515.8036172699764 820.9650713337601 612.5661372695588 701.7367839183111 485.5451707553414 609.0611436023044 449.6272451695728 843.4786661412663 658.7470469937971 687.3741869156918 0.7503971302507481 1.194349579837297 0.8911683751439616 1.0208948739653223 0.7063767886513532 0.8860692693963605 0.654122970760787 1.2271026206643416 0.9583529022956955 1.0 9.424951864720372 -7.776034900334545 24.998838286527842 1.0695457041418055 0.8849613370106009 0.2227053758885984 0.16110552338618844 390.5055888646614 668838.3528416428 0.08672707030711045 0.04195113225172748 1.674808281366773e-08 7.776034900334545 -0.18458436713120463 YQVSDGSLT(ph)VTSVSR ddPTM_A459_Selumetinib_30min_R1 1 YQVSDGSLTVTSVSR 15 0 H0YDP1;Q9UPX0;Q9UPX0-2 H0YDP1 IGSF9B Protein turtle homolog B 1 YQVS(0.084)DGS(0.084)LT(0.787)VT(0.044)SVSR 140.31 0.00091215 97852000.0 0.0 0.0 0.0 0.0 0.0 65.515 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 0.0 64.85597858286054 0.0 0.0 0.0 0.0 0.0 YQYGGLNSGRPVT(ph)PPR ddPTM_A459_Selumetinib_30min_R1 1 YQYGGLNSGRPVTPPR 16 1 P62140 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit 1 YQYGGLNSGRPVT(1)PPR 101.72 0.0073696 132660000.0 4512.6 5541.3 5356.7 5288.5 4759.0 4541.2 5381.7 5020.9 2722.8 4484.9 True False 4617.73480000892 4892.522019919522 4629.289562246897 4364.962752439971 4328.549290269691 4495.519651079697 4975.7540361684705 4887.729421818301 4620.392734556181 5060.580601625443 0.9124911079423806 0.9667906521137236 0.9147743957995617 0.8625418891733408 0.855346378413452 0.888340687555841 0.9832377799832441 0.9658436070059584 0.9130163311838417 1.0 12.30508719982537 -7.256472089761276 24.963418224839515 0.9626780640262849 0.900014028205684 0.4475654416317615 0.03558121533363054 454.8892779950263 2286081.202634054 0.015454640497875054 0.011582946935208968 5.540231474797211e-08 7.256472089761276 -0.06266403582060087 YREPPPT(ph)PPGYLGISLADLK ddPTM_A459_Selumetinib_30min_R1 1 YREPPPTPPGYLGISLADLK 20 1 E9PCH4;Q8TEU7;A0A5F9ZHG7;Q8TEU7-4 E9PCH4 RAPGEF6 Rap guanine nucleotide exchange factor 6 1 Y(0.003)REPPPT(0.997)PPGYLGISLADLK 93.104 0.0018036 19364000.0 3389.0 3345.5 3922.2 4084.7 3551.2 3213.9 3156.4 3205.6 1910.2 2566.2 True False 3467.9571061539295 2953.8073047192456 3389.586783102426 3371.3838243153164 3229.994587015281 3181.5710839877197 2918.310206767782 3120.5770747437177 3241.4698845119788 2895.5967669047723 1.197665761265847 1.020103122948537 1.1706004171035531 1.1643139897269374 1.1154849404214389 1.0987617890555381 1.0078441308274042 1.0776973888113008 1.1194479568289217 1.0 11.499644995200997 -6.9361996910532016 3.278344527363282 1.0571601606572254 1.1312101361653915 0.3306411832105526 0.054622106093583256 0.3289044707631255 7.181935486980868 0.020622626409774584 0.017502954915097867 1.1582446662648831e-07 6.9361996910532016 0.07404997550816605 YRLS(ph)PTLSSTK ddPTM_A459_Selumetinib_30min_R2 1 YRLSPTLSSTK 11 1 Q8NEM0-2;Q8NEM0-3;Q8NEM0 Q8NEM0-2 MCPH1 Microcephalin 1 YRLS(0.892)PT(0.027)LS(0.039)S(0.039)T(0.003)K 65.219 0.044616 18146000.0 110520.0 108310.0 118580.0 124270.0 118260.0 113620.0 103990.0 102780.0 106740.0 113110.0 True False 104377.74084661392 116617.0287284589 110950.69190014228 107344.21162229302 103403.12154218611 129270.12366033191 108825.74105227596 103079.0727838549 128090.98256478788 109844.22040492628 0.9502342541267906 1.0616583039013392 1.0100730970745402 0.9772404158050618 0.9413615132503476 1.1768495709996811 0.9907279659421695 0.9384114376147189 1.166114904294439 1.0 16.745099436938013 YRNEGS(ph)PSPR ddPTM_A459_Selumetinib_30min_R1 2 YRNEGSPSPR 10 1 Q5T200;Q5T200-2 Q5T200;Q5T200-2 ZC3H13 Zinc finger CCCH domain-containing protein 13 1 YRNEGS(0.793)PS(0.207)PR;YRNEGS(0.958)PS(0.042)PR 85.67200000000003 0.019872 14759600.0 2097.38 2595.63 2677.61 2586.39 3076.8 2372.86 2402.03 2495.48 1216.85 1799.47 True False 2146.24487320895 2291.732432924351 2314.0052690589187 2134.725539053268 2798.5039832531584 2348.9911827845003 2220.8429432145517 2429.291763938562 2064.9055747923785 2030.4495028221215 1.0570294263540583 1.1286823088873041 1.139651720391314 1.0513561337458595 1.3782682008902551 1.1568823452736143 1.093769108824328 1.1964305246508664 1.016969676873208 1.0 10.987583432616761 -8.279180803025344 19.036667832259067 1.008482879357918 1.151827249604168 0.29564858059833876 0.08750443050413777 54.498839687224 58463.9751214337 0.08355152267966355 0.022060922171169714 5.257983234315832e-09 8.279180803025344 0.14334437024625002 YRPAS(ph)ASVSALIGGR ddPTM_A459_Selumetinib_30min_R1 3 YRPASASVSALIGGR 15 1 P46108-2 P46108-2 CRK Adapter molecule crk 1 Y(0.001)RPAS(0.968)AS(0.031)VSALIGGR;YRPAS(0.973)AS(0.026)VSALIGGR;YRPAS(0.811)AS(0.178)VS(0.012)ALIGGR 165.24 0.00041627 446220000.0 6003.1 7427.799999999999 7715.8 7099.0 6039.6 6008.9 6504.200000000001 5172.0 4143.8 4153.900000000001 True False 6142.960550000782 6558.149722909462 6668.036739855619 5859.292914734108 5493.319246377983 5948.455921644674 6013.582957438537 5034.82175897633 7031.725948822503 4687.093527412408 1.3106118992663054 1.3991932707453363 1.4226378673388296 1.2500908890480011 1.172009735724362 1.2691139800934639 1.2830089526202482 1.0741884559226818 1.5002316270621745 1.0 12.1944778676565 -14.522878745280336 0.12053823160449909 0.1377881012628681 1.4202237059048377 0.33491167856159454 0.11986341916275978 177.43396291758478 1.3794388727833096 38.10791859785208 1.1221429331204613 3.0000000000000132e-15 14.522878745280336 1.2824356046419696 YRPGTVALR ddPTM_A459_Selumetinib_30min_R1 1 YRPGTVALR 9 1 K7EK07;Q5TEC6;Q6NXT2;Q71DI3;Q16695;P84243;P68431;K7EMV3;K7EP01;A0A590UJJ6;B4DEB1;K7ES00 K7EK07 H3F3B;HIST2H3PS2;H3F3C;HIST2H3A;HIST3H3;H3F3A;HIST1H3A Histone H3;Histone H3.3C;Histone H3.2;Histone H3.1t;Histone H3.3;Histone H3.1 0 131.62 0.010033 20137000.0 2461.6 2030.4 2751.9 2985.7 2669.7 2946.6 1940.5 2590.6 1514.4 1957.0 False True 2518.9504905602 1792.6798240926491 2378.2070951046785 2464.303543530304 2428.2261063738165 2916.9598792987385 1794.1265226944881 2521.8888725452575 2569.826192600223 2208.2000127942624 1.1407256933092365 0.8118285543455763 1.0769889871050624 1.115978411942842 1.0996404729212605 1.3209672413721298 0.8124837026987404 1.1420563617124757 1.163765137990538 1.0 11.108655138117673 -5.493515784070423 24.723030695360833 1.0974149893311298 0.9683100020542794 0.09533345198461995 0.14198925646016466 1234.9745193063234 1039822.0667154696 0.03584725736444861 0.07441680407308149 3.2098461429120373e-06 5.493515784070423 -0.12910498727685038 YRS(ph)DIHTEAVQAALAK ddPTM_A459_Selumetinib_30min_R1 2 YRSDIHTEAVQAALAK 16 1 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 Y(0.073)RS(0.927)DIHT(0.001)EAVQAALAK;Y(0.143)RS(0.848)DIHT(0.009)EAVQAALAK 137.21 0.00022430000000000006 58044000.0 8201.6 10126.3 10759.8 13035.7 10536.4 8957.9 8845.9 8164.6 4748.6 7858.7 True False 8392.681322464461 8940.708088410845 9298.678259350754 10759.259705395043 9583.3844803525 8867.791659122442 8178.646641125049 7948.04828564155 8058.027375978221 8867.440695220368 0.9464603836581837 1.0082625185449472 1.0486315701398292 1.213344422048899 1.0807384914925942 1.0000395789398697 0.9223232409700146 0.8963181777945942 0.9087207518987493 1.0 13.11430206121837 -7.050100780721419 3.1478505498643723 0.9236316626002254 1.0638950261086726 0.43256725224152826 0.06837377293597088 0.25384029836738103 5.01269114376702 0.030248551345077992 0.023741450454135626 8.910441418346688e-08 7.050100780721419 0.14026336350844715 YRS(ph)DIHTEAVQAALAK ddPTM_A459_Selumetinib_30min_R2 2 YRSDIHTEAVQAALAK 16 1 Q9P265 Q9P265 DIP2B Disco-interacting protein 2 homolog B 1 Y(0.397)RS(0.601)DIHT(0.002)EAVQAALAK;Y(0.158)RS(0.704)DIHT(0.138)EAVQAALAK 134.02 0.00026749 21938000.0 198622.0 196498.0 238120.0 245080.0 249570.0 159881.0 163452.0 181801.0 155641.0 195682.0 True False 187583.38438686373 211568.76475934568 222799.61844545318 211699.68121341837 218216.78541589165 181903.1564947854 171052.84187399357 182330.01081122409 186773.54897288865 190032.15221710538 0.9871139288711311 1.1133314141368849 1.1724311693892309 1.1140203315255754 1.1483150765276091 0.9572230507970415 0.900125793863406 0.9594692723519657 0.9828523583709462 1.0 17.535884008360703 -6.770601511092149 24.872510848603632 0.953662862708731 1.1114121488245379 0.6703838181029425 0.05143680633684056 107.30510209373978 291300.2284645115 0.018521659348356322 0.016563933346507582 1.6958931613773553e-07 6.770601511092149 0.15774928611580685 YRS(ph)DSQDEVEK ddPTM_A459_Selumetinib_30min_R1 1 YRSDSQDEVEK 11 1 H0YBZ4;Q15390-2;Q15390;H7C5V5;H0YF01 H0YBZ4 MTFR1 Mitochondrial fission regulator 1 1 Y(0.005)RS(0.606)DS(0.389)QDEVEK 95.428 0.040522 0.0 2396.3 2963.1 2986.6 3243.0 3055.7 2305.5 3061.5 2923.5 1565.7 2207.3 True False 2452.129127611879 2616.1788744921832 2581.036124219497 2676.670928649488 2779.3124745276527 2282.3087632265133 2830.568590172208 2845.959283133662 2656.8785457964636 2490.628455922726 0.9845423237579675 1.0504091319887146 1.0362991389108165 1.0746969995803075 1.1159081025989384 0.9163585832319439 1.1364876938754565 1.1426671354235747 1.066750257140279 1.0 11.282294105607754 YRS(ph)DVHTEAVQAALAK ddPTM_A459_Selumetinib_30min_R2 1 YRSDVHTEAVQAALAK 16 1 E7EPU2;A0A0U1RQW6;Q9Y2E4 E7EPU2 DIP2C Disco-interacting protein 2 homolog C 1 Y(0.071)RS(0.923)DVHT(0.005)EAVQAALAK 95.307 0.030385 0.0 31613.0 27995.0 30228.0 32045.0 34020.0 27373.0 26999.0 32087.0 19818.0 27058.0 True False 29856.076016865823 30142.126481887302 28283.16338975794 27680.41571929166 29746.103457341193 31143.382282646206 28254.50699750355 32180.3678577112 23782.153761185727 26276.7652348731 1.1362158070066577 1.147101867846515 1.0763563603415713 1.0534179329865045 1.1320306434775227 1.1852060938351117 1.0752658002213187 1.2246700676460418 0.9050639813771043 1.0 14.681500065147135 -8.272198388728963 24.998551061549197 0.9525319730506421 1.1253390815968893 0.6337168831574289 0.05354729979247866 503.47927954726043 1169820.5110559918 0.04863331003514221 0.013080979879386842 5.3432022245907414e-09 8.272198388728963 0.17280710854624726 YRS(ph)PEPDPYLSYR ddPTM_A459_Selumetinib_30min_R1 3 YRSPEPDPYLSYR 13 1 H3BRT8;H3BQR7;H3BV35;H3BRK0;H3BUL5;H3BVF8;H3BQG1;P49761-2;P49761-3;P49761-1;P49761 H3BRT8 CLK3 Dual specificity protein kinase CLK3 1 Y(0.022)RS(0.978)PEPDPYLSYR;YRS(1)PEPDPYLSYR;Y(0.394)RS(0.606)PEPDPYLSYR 154.47 0.00021112 191160200.0 10057.8 11648.8 12670.0 13171.9 10872.1 9977.5 10885.099999999999 9507.099999999999 5879.19 8194.3 True False 10292.127170928 10284.953080619802 10949.483591328271 10871.674932185688 9888.720474625157 9877.135408845174 10064.028143355716 9254.940824586976 9976.556030951728 9246.118224241201 1.1131295232570577 1.1123536203176607 1.1842249175033515 1.1758096390853676 1.0694996791950162 1.068246713842528 1.0884598162470107 1.0009541950613008 1.078999401586223 1.0 13.174632094179058 -6.389058139991538 4.680074174974227 1.0517513554921063 1.1463101948039158 0.6426152077083729 0.035019697029154986 0.1575857524785044 5.316829141890615 0.011416039080961855 0.012964405817665905 4.082647273451082e-07 6.389058139991538 0.09455883931180953 YRS(ph)PEPDPYLSYR ddPTM_A459_Selumetinib_30min_R2 4 YRSPEPDPYLSYR 13 1 H3BRT8;H3BQR7;H3BV35;H3BRK0;H3BUL5;H3BVF8;H3BQG1;P49761-2;P49761-3;P49761-1;P49761 H3BRT8 CLK3 Dual specificity protein kinase CLK3 1 Y(0.402)RS(0.598)PEPDPYLSYR;Y(0.147)RS(0.853)PEPDPYLSYR;YRS(1)PEPDPYLSYR;Y(0.004)RS(0.996)PEPDPYLSYR 170.74 0.0010437 104343000.0 162593.0 160079.0 192631.0 196117.0 209345.0 160185.0 155529.0 158013.0 144475.0 160745.0 True False 153556.73197134925 172356.54456488782 180237.33118077455 169405.52627930464 183045.2095319543 182249.02973534825 162761.40667486688 158472.7916695398 173374.03696878103 156103.87418433288 0.9836830301214954 1.1041144588209466 1.1545987062944 1.0852102624901205 1.1725859495057 1.167485628961023 1.0426480926583062 1.0151752638913343 1.1106325059175337 1.0 17.252146816987526 -7.296495189747709 23.22479352218716 1.0433785093252985 1.1145247009718466 0.2565499284560149 0.0575064343338109 383.8558189565828 254305.56062054876 0.02454790912207691 0.01655128849309424 5.052482410463716e-08 7.296495189747709 0.07114619164654812 YRS(ph)PYSGPK ddPTM_A459_Selumetinib_30min_R1 4 YRSPYSGPK 9 1 G3XAC6;Q14498-2;Q14498;Q5QP23;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 YRS(1)PYSGPK;YRS(0.99)PYS(0.01)GPK;YRS(1)PYSGPK;YRS(1)PYSGPK 152.67 0.0051369 3023980000.0 30017.2 36014.3 38321.4 39352.4 33273.0 29534.1 33911.0 29258.700000000004 15838.899999999998 25205.6 True False 30716.542356696307 31797.729013406162 33117.56436438259 32480.242076036448 30263.46302482528 29237.013768817233 31353.065968097286 28482.664230348168 26877.456472514277 28440.984283335234 1.0800098214144584 1.1180249142093788 1.164431020897809 1.1420224332766142 1.0640793132661697 1.027988816334617 1.1023903271332407 1.0014654889084607 0.9450255379615292 1.0 14.795683774046662 -7.32468512643925 0.7702256675338921 0.9733825575467572 1.1254603311662863 0.6641574960654337 0.03856222629243717 0.42312433156283485 0.48648942140194484 0.034562680578562266 0.020426756888794785 4.7349442897387115e-08 7.32468512643925 0.15207777361952912 YRS(ph)PYSGPK ddPTM_A459_Selumetinib_30min_R2 2 YRSPYSGPK 9 1 G3XAC6;Q14498-2;Q14498;Q5QP23;Q5QP22 G3XAC6 RBM39 RNA-binding protein 39 1 YRS(0.999)PYSGPK;Y(0.003)RS(0.997)PYSGPK 121.29 0.029952 2811130000.0 661690.0 596340.0 709620.0 749330.0 726900.0 534062.0 569530.0 593420.0 479063.0 676320.0 True False 624915.9187549404 642077.3604646771 663963.8217758376 647269.9613336499 635580.3234315492 607624.1927678592 596014.2735022849 595146.7539540298 574888.9861386075 656792.8843096073 0.951465726386219 0.9775948793044575 1.0109181107736391 0.9855008737100319 0.9677028156290765 0.9251382091427008 0.9074615266710596 0.9061406847907962 0.8752972205886583 1.0 19.325078971487287 -6.732360089575821 2.7981289897570614 0.9143813166235905 0.9828362096993445 0.4157523649808579 0.0328541017671836 0.2285148622788959 3.665652679467804 0.01170156034848191 0.011051338426601474 1.8519954289158868e-07 6.732360089575821 0.06845489307575403 YRSDS(ph)QDEVEK ddPTM_A459_Selumetinib_30min_R1 1 YRSDSQDEVEK 11 1 H0YBZ4;Q15390-2;Q15390;H7C5V5;H0YF01 H0YBZ4 MTFR1 Mitochondrial fission regulator 1 1 Y(0.001)RS(0.006)DS(0.993)QDEVEK 138.19 0.006036100000000001 20154000.0 4287.9 5160.5 4883.5 6714.2 5041.8 4257.6 4556.4 4094.3 2460.6 3742.1 True False 4387.799727199005 4556.306260948639 4220.347523145353 5541.691011143507 4585.770080202086 4214.7724095915 4212.707079621316 3985.7058638392864 4175.458484886491 4222.434986140729 1.0391633599098746 1.079070791120236 0.9995056257817521 1.3124396300553978 1.08604871247371 0.99818527068519 0.997696138235084 0.9439354014736859 0.9888745471727974 1.0 12.043859494333047 -6.756309629239344 4.35006073704853 0.981380398498741 1.109140125644947 0.36202056537120175 0.078377706976688 0.2321841129546792 10.405593869929392 0.02855536749384001 0.026823684272327755 1.7526305224608814e-07 6.756309629239344 0.12775972714620587 YRSDS(ph)QDEVEK ddPTM_A459_Selumetinib_30min_R2 3 YRSDSQDEVEK 11 1 H0YBZ4;Q15390-2;Q15390;H7C5V5;H0YF01 H0YBZ4 MTFR1 Mitochondrial fission regulator 1 1 Y(0.382)RS(0.022)DS(0.597)QDEVEK;YRS(0.043)DS(0.957)QDEVEK;Y(0.004)RS(0.02)DS(0.976)QDEVEK 114.69 0.025199 5782100.0 105878.0 113394.0 107715.0 103454.0 104643.0 81117.0 86322.0 87972.0 70252.0 98915.0 True False 99993.72462321559 122090.9551808226 100784.73417122471 89363.38673189556 91496.81081971069 92290.13044318893 90336.14404379805 88227.98395545137 84304.36300488531 96059.0669379656 1.0409608151596035 1.2709987622476933 1.0491954313517424 0.9302962185714955 0.9525057210767913 0.9607643857584977 0.940422876500941 0.9184763788349986 0.8776304589688403 1.0 16.551634174690385 -5.553848644421196 4.082976325118202 0.9390127665907271 1.1587339945907111 0.678498537042187 0.05974282445824645 0.10284983899886051 3.8103100691269787 0.015421983086297783 0.02954867265739463 2.7935172377856753e-06 5.553848644421196 0.21972122799998406 YRTEAHQDVVGR ddPTM_A459_Selumetinib_30min_R2 1 YRTEAHQDVVGR 12 1 A0A087WV29;Q9H0A0-2;Q9H0A0;E9PMU0 A0A087WV29 NAT10 N-acetyltransferase 10 0 80.979 0.03115 681830.0 4904.0 3664.5 4678.2 5489.2 5260.2 3410.3 2962.5 4025.1 4006.7 6820.8 False True 4631.45531226742 3945.555366775353 4377.2097052390345 4741.561490601834 4599.366649215347 3880.037869378893 3100.2621200823837 4036.8123746088213 4808.151956551763 6623.865781433308 0.6992073005539131 0.5956575052946789 0.6608240338305692 0.7158299469008608 0.6943628993974137 0.5857663783367466 0.4680442240802065 0.6094345066477651 0.7258830591086265 1.0 12.693457724645707 -8.660731133828477 3.0991628761801806 0.9998241368485045 0.6277644183438996 0.72622398720782 0.06870708224602641 0.3463481971136355 6.460048899153098 0.07367118020841565 0.019557749943488318 2.18408163044934e-09 8.660731133828477 -0.37205971850460484 YS(ph)CPESPSQELGGPLPSPGPR ddPTM_A459_Selumetinib_30min_R1 1 YSCPESPSQELGGPLPSPGPR 21 0 A0A494BZV2;A0A1W2PPU9 A0A494BZV2 1 Y(0.317)S(0.44)CPES(0.231)PS(0.008)QELGGPLPS(0.005)PGPR 81.789 0.0017019 20716000.0 546.42 694.15 887.67 898.07 663.93 646.44 784.3 655.9 472.99 666.84 True False 559.1505228517644 612.8785952984202 767.1292896222866 741.2389333617778 603.877648726362 639.9374005205581 725.1396195564477 638.5034013365376 802.6294841772174 752.4354095716537 0.7431209586083641 0.8145265194886557 1.0195284271097738 0.9851196846035597 0.8025641019076141 0.850488151381474 0.9637234111154537 0.8485823410411064 1.0667088150917008 1.0 9.55542393338779 -5.052169916827186 5.536291782619301 0.9305730518643551 0.7579685804067088 0.40211410509197965 0.08072773527165661 0.18527311103018004 12.972966600393443 0.020872309722845254 0.06146114158025063 8.868089819558008e-06 5.052169916827186 -0.17260447145764635 YS(ph)DDGNRETDEK ddPTM_A459_Selumetinib_30min_R1 2 YSDDGNRETDEK 12 1 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 YS(1)DDGNRETDEK;YS(1)DDGNRETDEK 164.92 0.00013579 5897900.0 2460.2 3231.1 2121.4300000000003 1987.43 2782.6 2217.21 3335.1 3379.2 1695.6 3414.1 True False 2517.517873284126 2852.801309902363 1833.3514581808631 1640.3626591815764 2530.9143213079296 2194.906880465608 3083.5307218955845 3289.5726388114467 2877.3093582758406 3852.332991150174 0.6535047409109049 0.7405386077621017 0.4759067978787284 0.4258101942251416 0.6569822305398074 0.5697604245292109 0.8004320314415365 0.8539170020786011 0.7469004794979509 1.0 11.911516698102444 -7.33404465858971 3.6348786874368257 0.8473961008426965 0.5838005682488521 0.6136246851762177 0.10278099934874513 0.18439153956741583 4.756283810819367 0.048130650560697895 0.031654401175412204 4.633992658456507e-08 7.33404465858971 -0.2635955325938444 YS(ph)DDGNRETDEK ddPTM_A459_Selumetinib_30min_R2 1 YSDDGNRETDEK 12 1 A0A075B785;A0A2R8Y566;Q9P260;Q9P260-2 A0A075B785 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 YS(1)DDGNRETDEK 164.92 0.0024432 7419800.0 32494.0 20358.0 24748.0 33574.0 26834.0 25628.0 31688.0 29862.0 22646.0 19870.0 True False 30688.113563788225 21919.393138712694 23155.74062358507 29001.163281619545 23462.873020996285 29158.02437217907 33161.554788580775 29948.89347607978 27175.83278210779 19296.301471539977 1.590362464488336 1.1359375355449075 1.2000092690165192 1.502938960836263 1.2159259149014419 1.5110680362858189 1.7185446049073494 1.5520535642672901 1.4083441234678726 1.0 14.236036731706166 -6.780468701788765 24.795407784287516 1.490039377599181 1.3208004465901282 0.03260866205036306 0.21654490084318734 474.80640287330766 618673.3025128377 0.0737054819677075 0.06510938735342581 1.6577968046458529e-07 6.780468701788765 -0.16923893100905274 YS(ph)GAYGASVSDEELK ddPTM_A459_Selumetinib_30min_R1 3 YSGAYGASVSDEELK 15 0 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 YS(1)GAYGASVSDEELK;YS(0.996)GAYGAS(0.004)VSDEELK;Y(0.001)S(0.999)GAYGASVSDEELK 268.18 8.383600000000001e-45 205602000.0 11997.400000000001 10623.600000000002 10166.9 8419.6 8619.5 10647.5 9825.8 12022.79 6874.360000000001 9692.230000000001 True False 12276.916077123386 9379.783973222351 8786.290822784167 6949.274915466303 7839.867746896323 10540.3958171565 9084.631995203039 11703.9065536742 11665.286836610712 10936.322130814991 1.1225817903197124 0.8576726125132302 0.8034045374383463 0.635430708088372 0.716865108134126 0.9637971240310396 0.8306843824219028 1.0701867057021306 1.066655379850392 1.0 13.416840023005182 -7.759431545458596 24.89347162893159 1.051315821262794 0.8372491673334487 0.34206800199882814 0.1254920370176913 56.9623755951724 706261.3026394539 0.06681369419817514 0.03608755903520098 1.7400769515402165e-08 7.759431545458596 -0.21406665392934532 YS(ph)GAYGASVSDEELK ddPTM_A459_Selumetinib_30min_R2 4 YSGAYGASVSDEELK 15 0 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 YS(1)GAYGASVSDEELK;Y(0.035)S(0.965)GAYGASVSDEELK;Y(0.001)S(0.999)GAYGASVSDEELK;Y(0.001)S(0.999)GAYGASVSDEELK 179.81 1.3621e-09 67850000.0 640282.0 521354.0 603704.0 722874.0 634076.0 551393.0 688113.0 671820.0 558058.0 553387.0 True False 604697.6896919259 561340.1753826694 564862.3419032149 624417.3141727952 554417.7041686377 627342.380702705 720111.6179700419 673774.8849742117 669685.1934433222 537409.2794379005 1.1252088730667344 1.0445301130077234 1.0510840871486788 1.1619027397999158 1.0316489226768228 1.1673456427080482 1.3399687082501397 1.2537462800771542 1.2461362672110439 1.0 19.035661706996414 -6.9855598015771 7.59672351151815 1.2343826547096253 1.0846131878646752 0.3000106145929037 0.0893109136006855 0.15246771442393853 48.33198219497858 0.03025943876591461 0.026083967313507518 1.0338087375580519e-07 6.9855598015771 -0.14976946684495007 YS(ph)GAYGASVSDEELKR ddPTM_A459_Selumetinib_30min_R1 2 YSGAYGASVSDEELKR 16 1 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 Y(0.068)S(0.932)GAYGASVSDEELKR;YS(1)GAYGASVSDEELKR 257.48 1.1379999999999999e-38 25299100.0 6875.6 6549.7 6067.2 6257.4 5652.9 6803.3 5918.900000000001 6700.799999999999 3865.1000000000004 6368.6 True False 7035.788102411322 5782.858079127077 5243.307564744034 5164.662555945515 5141.596193100557 6734.864978902163 5472.432607666275 6523.073016734061 6558.792404265134 7186.071845417245 0.9790868020472461 0.8047314587892639 0.7296486421977307 0.7187045533421937 0.7154946824501196 0.9372109163084935 0.7615332445021677 0.9077383523369591 0.9127089939196552 1.0 12.810987643952766 -8.203207591592314 0.9545604500400534 0.9969171938852308 0.7954620976480985 0.3445523380451685 0.086295496067335 0.5962862586855947 1.105331495353237 0.08361249416390569 0.029907817377835943 6.263144165065969e-09 8.203207591592314 -0.20145509623713231 YS(ph)GAYGASVSDEELKR ddPTM_A459_Selumetinib_30min_R2 4 YSGAYGASVSDEELKR 16 1 A0A286YEX5;C9JRZ6;F8WAR4;Q9NX63 A0A286YEX5 CHCHD3 MICOS complex subunit MIC19 1 YS(1)GAYGASVSDEELKR;Y(0.039)S(0.948)GAY(0.013)GASVSDEELKR;Y(0.005)S(0.993)GAYGAS(0.001)VSDEELKR;Y(0.185)S(0.804)GAY(0.006)GAS(0.005)VSDEELKR 239.58 3.6898e-21 43475900.0 118152.0 75699.0 115329.0 141227.0 138547.0 120870.0 160719.0 130787.0 117142.0 109479.0 True False 111585.58483993061 81504.8698893513 107908.85770072116 121991.63896983613 121141.48723410485 137518.74535138454 168192.7519586567 131167.5685170466 140573.6732209518 106318.05680939728 1.0495449991150303 0.7666136151779932 1.0149626595807315 1.147421638720672 1.1394253325310715 1.2934655643483268 1.5819772953543147 1.2337280463298772 1.3221994216181605 1.0 16.698027116057204 -6.030639828112958 1.2803323459073894 1.310235325875485 0.9046893102195016 0.46703095062850586 0.15340311120553923 0.35871427099620157 1.1947960259438355 0.05640928907264127 0.10225326303905051 9.318803881152784e-07 6.030639828112958 -0.40554601565598347 YS(ph)GSYNDYLR ddPTM_A459_Selumetinib_30min_R2 2 YSGSYNDYLR 10 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 Y(0.046)S(0.749)GS(0.205)YNDYLR;Y(0.048)S(0.951)GS(0.001)YNDYLR 108.98 0.010346 15094400.0 42068.0 40230.0 42036.0 51269.0 50664.0 44494.0 33698.0 41340.0 38977.0 47097.0 True False 39730.02897154687 43315.511640161654 39331.44952533625 44286.07375604196 44299.135378093306 50622.6446236825 35265.02377132021 41460.292555794564 46773.48910837301 45737.18723729835 0.8686592108389934 0.9470523715292698 0.8599446511931921 0.9682727870052967 0.9685583669204668 1.1068158686942624 0.7710361283992959 0.9064897747359504 1.0226577525569733 1.0 15.481080024626161 -5.778102753204762 24.98528021285831 0.9576830160501902 0.8974021009115187 0.12856417011380783 0.0840450150626204 590.9704025335094 886106.8297378211 0.02440151675386201 0.03630554851058646 1.666852791860577e-06 5.778102753204762 -0.06028091513867151 YS(ph)PESQAQSVHHQRPGSR ddPTM_A459_Selumetinib_30min_R2 1 YSPESQAQSVHHQRPGSR 18 1 O75376-2;O75376;A0A088AWL3;E7EVK1;J3KS29;J3QKP0 O75376-2 NCOR1 Nuclear receptor corepressor 1 1 Y(0.445)S(0.537)PES(0.018)QAQSVHHQRPGSR 67.646 0.012455 1007100.0 2245.7 1324.5 3462.6 3625.2 5249.3 2818.9 2653.1 3701.4 4608.4 4691.5 True False 2120.892984249376 1426.0848910612503 3239.8200857938277 3131.4415061811856 4589.836004662585 3207.1778875735736 2776.474407017916 3712.1704612002413 5530.208769454448 4556.04420501911 0.4655119416780285 0.31300945005981756 0.7111037426337347 0.6873158743129558 1.0074169165448938 0.7039391505553052 0.60940462429211 0.8147792896984568 1.2138180668576835 1.0 12.15356602952472 -4.986195737930045 0.33193588513172523 0.9909886080759746 1.401384643914845e-27 0.565778935069047 0.167644420447997 5.139302566785614 0.507506383757419 0.18648900018986062 2.0380644746016965 1.0322960417282408e-05 4.986195737930045 -0.9909886080759746 YS(ph)PPAISPLVSEK ddPTM_A459_Selumetinib_30min_R1 2 YSPPAISPLVSEK 13 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 Y(0.151)S(0.849)PPAISPLVSEK;Y(0.004)S(0.996)PPAISPLVSEK 122.78 0.0025804 63694000.0 5919.1 8346.7 4875.4 5267.299999999999 5595.9 5653.0 7113.0 6791.1 3736.89 7033.4 True False 6057.003513436329 7369.464483724446 4213.3474586552375 4347.464934466681 5089.751833036387 5596.135952513328 6576.4606832908485 6610.977967398325 6341.229398353035 7936.205401117612 0.7632115359039666 0.928587922218677 0.5309020174883446 0.5478014636383343 0.6413331782364939 0.705140009572491 0.8286656343804712 0.8330149779726388 0.7990253626071768 1.0 12.954233650021324 -7.294458138926828 2.661176036240915 0.8597761890501102 0.6790535362920569 0.36816851872582546 0.115778889655762 0.37755776648331785 5.293656488185677 0.059306428603850304 0.038802233373501215 5.076236658475104e-08 7.294458138926828 -0.18072265275805333 YS(ph)PPAISPLVSEK ddPTM_A459_Selumetinib_30min_R2 3 YSPPAISPLVSEK 13 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 Y(0.062)S(0.937)PPAISPLVSEK;Y(0.001)S(0.999)PPAISPLVSEK;Y(0.009)S(0.991)PPAISPLVSEK 127.3 0.001941 36372000.0 67073.0 51334.0 63025.0 64267.0 73584.0 62746.0 79861.0 82131.0 77792.0 55628.0 True False 63345.351174492826 55271.15273517419 58970.04011643159 55513.723733241284 64339.72007069352 71388.691948523 83574.69474156947 82369.98761248101 93352.57369008799 54021.87510109837 1.1725870502633644 1.0231254030286412 1.0915955806064315 1.0276156395784304 1.1909938325962581 1.3214774906447395 1.5470528297132404 1.5247524721852217 1.7280513405983189 1.0 15.721256096258722 -6.835595635915295 2.053653629785318 1.4923548961577837 1.0782151039648642 0.45673618851455255 0.17959967220129763 0.24933480307126923 2.1584717617316875 0.06959921877060989 0.060816630221529396 1.460173169545714e-07 6.835595635915295 -0.4141397921929195 YS(ph)PPRDDDKVDNQAK ddPTM_A459_Selumetinib_30min_R2 1 YSPPRDDDKVDNQAK 15 2 Q14669;Q14669-2;Q14669-3;Q14669-4 Q14669 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 Y(0.231)S(0.769)PPRDDDKVDNQAK 91.932 0.015854 74665000.0 43100.0 50186.0 41458.0 41312.0 41958.0 30565.0 38262.0 42235.0 28789.0 40320.0 True False 40704.67454297018 54035.10482657604 38790.63741605742 35685.234332825 36686.86093072081 34775.051308555194 40041.25881471466 42357.89685761935 34547.60443186882 39155.85683605897 1.0395551989424194 1.3800005718892772 0.9906726745495398 0.9113638984388704 0.9369444036003206 0.8881187673699569 1.0226122488485634 1.081776783354964 0.8823100098796365 1.0 15.256940497956412 -5.4036636000850775 7.624684579194294 0.9616542316766127 1.2085094241752092 0.5123809763122826 0.09617080957162764 0.1902862765038102 11.136398433250902 0.024093755319885977 0.05039932949074786 3.947629628973478e-06 5.4036636000850775 0.24685519249859655 YS(ph)PSQNS(ph)PIHHIPSR ddPTM_A459_Selumetinib_30min_R1 2 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 2 Y(0.157)S(0.841)PS(0.198)QNS(0.803)PIHHIPSR;Y(0.044)S(0.951)PS(0.009)QNS(0.997)PIHHIPSR 139.7 0.0015672 61952000.0 6158.4 8990.3 4429.0 4367.9 5878.799999999999 5990.1 8037.299999999999 6820.6 3040.7 6627.4 True False 6301.878737839586 7937.711496522919 3827.5661267555597 3605.1282606377117 5347.063577986435 5929.845032575639 7431.039990132645 6639.695531568822 5159.84581605883 7478.091346342718 0.8427121903133241 1.061462227310848 0.5118373057354392 0.48209203306948883 0.7150305245470829 0.7929623693986737 0.9937081062491856 0.8878863902640174 0.6899950237412299 1.0 12.8684543787668 -6.999595655097731 5.038381095272919 0.8855102640723941 0.7185658635005779 0.1782783693900486 0.17172099391722773 0.36937804344812547 27.659692211014175 0.07025569248009639 0.058370060012365256 1.0009314720953189e-07 6.999595655097731 -0.16694440057181614 YS(ph)PSQNS(ph)PIHHIPSR ddPTM_A459_Selumetinib_30min_R2 2 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 2 Y(0.036)S(0.962)PS(0.006)QNS(0.997)PIHHIPSR;Y(0.191)S(0.807)PS(0.161)QNS(0.841)PIHHIPSR 126.04 0.0047015 65033000.0 80482.0 57981.0 85201.0 96398.0 106412.0 88508.0 99072.0 105527.0 93242.0 83064.0 True False 76009.13263497272 62427.95626170058 79719.26041983473 83268.42610417478 93043.57322464995 100699.17360437122 103679.04430744382 105834.06609906476 111893.00539915632 80665.72649380944 0.9422729570384011 0.7739093041763098 0.9882668127454681 1.0322652472554756 1.153446169381372 1.2483514124440347 1.2852923888982826 1.3120078464450056 1.3871195396441804 1.0 16.299668206455735 -6.095082044978252 1.143852987330411 1.2739786924254868 0.8578199243138526 0.6769134239753681 0.10532521386123006 0.2573517943498347 0.6898967931584247 0.04017580790448889 0.0714353397345094 8.033743379488768e-07 6.095082044978252 -0.4161587681116342 YS(ph)PSQNSPIHHIPS(ph)R ddPTM_A459_Selumetinib_30min_R1 1 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 2 Y(0.329)S(0.671)PS(0.021)QNS(0.444)PIHHIPS(0.536)R 124.82 0.02334 15236000.0 1595.3 2308.6 877.05 919.04 1606.7 1551.9 1813.5 1734.5 777.78 1399.4 True False 1632.4673860865635 2038.3080387609762 757.951427290802 758.5469165174298 1461.3742686859248 1536.2892950124597 1676.7062349427736 1688.4954255499683 1319.8358531963818 1579.026621310317 1.033844118936956 1.2908636315894 0.4800118104796956 0.4803889347273753 0.9254905832260375 0.9729343851958665 1.0618606502982195 1.0693267629324774 0.8358540859185438 1.0 10.624819778918262 -6.513583581157352 24.167749639666734 0.9916411773677034 0.8145050535866744 0.10344653316637675 0.23112803540434387 740.3019098898809 1924818.7555226756 0.08219171607597472 0.08669688110312683 3.0649007741512783e-07 6.513583581157352 -0.17713612378102905 YS(ph)PSQNSPIHHIPSR ddPTM_A459_Selumetinib_30min_R1 3 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 Y(0.002)S(0.96)PS(0.038)QNSPIHHIPSR;Y(0.062)S(0.889)PS(0.05)QNSPIHHIPSR;Y(0.054)S(0.717)PS(0.222)QNS(0.007)PIHHIPSR 131.9 0.00044359 24830300.0 2514.55 2908.9199999999996 2521.23 2568.4 2600.6299999999997 2320.17 2754.9399999999996 2106.15 1118.64 2105.73 True False 2573.1341225374345 2568.342294079782 2178.860814125065 2119.877154839146 2365.4034756785168 2296.8311963458077 2547.132657785082 2050.288060260633 1898.2503777669776 2376.020957047145 1.0829593547589142 1.0809426097283452 0.9170208737690996 0.8921963203025247 0.9955314024747393 0.9666712701053982 1.072016073860977 0.8629082391632924 0.7989198799517627 1.0 11.214331845756426 -5.255383973146167 23.82337413057895 0.9394684090974226 1.081951023902015 0.38211638380227775 0.07312450943246851 274.514214328018 1079985.5436777472 0.0198151392785039 0.049492007718409274 5.554129823787316e-06 5.255383973146167 0.14248261480459234 YS(ph)PSQNSPIHHIPSR ddPTM_A459_Selumetinib_30min_R2 4 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 Y(0.4)S(0.496)PS(0.104)QNSPIHHIPSR;Y(0.007)S(0.991)PS(0.002)QNSPIHHIPSR;Y(0.001)S(0.986)PS(0.013)QNSPIHHIPSR;Y(0.015)S(0.944)PS(0.04)QNSPIHHIPSR 171.85 2.8481e-05 99888000.0 77675.0 65123.3 78356.0 95338.0 106842.0 76673.0 76153.0 76450.0 84319.0 95622.0 True False 73358.13445766148 70118.04770558639 73314.6602675623 82352.79993277663 93419.55278040117 87234.00978180439 79694.26539430686 76672.45684302114 101185.1560697054 92861.14440420723 0.7899766358504825 0.7550848975151072 0.7895084724396382 0.8868380899368444 1.0060133695290605 0.9394027000366378 0.8582089517162592 0.8256678004018586 1.0896393396711255 1.0 16.502787440080354 -5.840852658313915 3.2613290822813727 0.9395486398854564 0.7728829651550114 0.5399468647348784 0.0715110767669809 0.20099967520217368 4.2670697545834875 0.021158093502148513 0.0344023362115209 1.4426046963466083e-06 5.840852658313915 -0.16666567473044502 YS(ph)PSQNSPIHHIPSRR ddPTM_A459_Selumetinib_30min_R2 1 YSPSQNSPIHHIPSRR 16 1 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 Y(0.012)S(0.494)PS(0.494)QNSPIHHIPSRR 84.581 0.01167 3010000.0 5743.2 8376.6 8837.5 15335.0 15170.0 7108.6 4513.2 5682.7 5983.4 12256.0 True False 5424.01593585119 9019.058284985782 8268.904871542463 13246.346545649472 13264.208978479308 8087.745124554083 4723.07274273614 5699.235716178373 7180.247190164429 11902.137435087761 0.45571780408627044 0.7577679500152134 0.6947411686883694 1.1129384631872048 1.1144392383989896 0.679520394438669 0.39682559275550106 0.4788413633484773 0.603273758963403 1.0 13.53893306149409 -6.993406477213188 24.985056548667075 0.5708577961483017 0.8383110708932825 0.1383373040429352 0.23433142041347568 265.5441539560793 1006228.9521642374 0.08575143379130766 0.07544824525365726 1.0152979815390946e-07 6.993406477213188 0.2674532747449808 YS(ph)PVSK ddPTM_A459_Selumetinib_30min_R1 1 YSPVSK 6 0 A0A590UK48;Q12959;Q12959-3;Q12959-5;Q12959-8;A0A590UJ64;Q12959-7;A0A590UKA8;A0A590UJC5;A0A590UJR5;A0A590UJ81;A0A590UJ18;A0A590UJ68;A0A590UJS9;A0A590UJX2;A0A590UJ29;A0A590UK81;A0A590UJR4;E7EQD7;A0A590UK02;A0A590UK70;A0A590UJL2;A0A590UJ25;Q12959-9;Q12959-6;H7C166;A0A590UJ08;A0A0C4DFT3;A0A590UJD9;Q12959-4;Q12959-2 A0A590UK48;A0A590UJ08 DLG1 Disks large homolog 1 1 Y(0.018)S(0.966)PVS(0.016)K 95.815 0.038275 36524000.0 7335.6 8339.8 6119.4 5499.8 6410.7 5903.8 7519.1 7837.1 4122.9 8012.8 True False 7506.505207407134 7363.372338932168 5288.41909145811 4539.3631740322135 5830.8533169010125 5844.413132221506 6951.928233337857 7629.2346495114825 6996.260175298107 9041.320931281487 0.830244304395374 0.8144133357169202 0.5849166434476458 0.5020685814090242 0.6449116629327045 0.646411423357487 0.7689062567489807 0.8438185866310289 0.7738095161617585 1.0 13.142317849536125 -8.32329688281305 0.8051185705953778 0.9839419850529991 0.6666664301267728 0.4818074046220976 0.0998739182869809 0.57693046753781 0.8261642267069891 0.1069967926702799 0.04074390046069394 4.750103987999183e-09 8.32329688281305 -0.3172755549262263 YS(ph)PVSK ddPTM_A459_Selumetinib_30min_R2 1 YSPVSK 6 0 A0A590UK48;Q12959;Q12959-3;Q12959-5;Q12959-8;A0A590UJ64;Q12959-7;A0A590UKA8;A0A590UJC5;A0A590UJR5;A0A590UJ81;A0A590UJ18;A0A590UJ68;A0A590UJS9;A0A590UJX2;A0A590UJ29;A0A590UK81;A0A590UJR4;E7EQD7;A0A590UK02;A0A590UK70;A0A590UJL2;A0A590UJ25;Q12959-9;Q12959-6;H7C166;A0A590UJ08;A0A0C4DFT3;A0A590UJD9;Q12959-4;Q12959-2 A0A590UK48;A0A590UJ08 DLG1 Disks large homolog 1 1 Y(0.261)S(0.739)PVSK 93.162 0.042286 79141000.0 408540.0 288150.0 301460.0 372890.0 328360.0 289570.0 455340.0 375400.0 317010.0 324850.0 True False 385834.982315198 310250.1784517169 282064.3918048305 322101.7387288706 287108.4812243551 329455.6390452588 476514.2122390931 376492.35184918455 380420.85799946997 315470.7364383374 1.2230452392233664 0.9834515300989227 0.894106359877736 1.0210193895173831 0.9100954480463324 1.0443302689967724 1.5104862581516607 1.193430351416365 1.2058831899732412 1.0 18.267146659190274 -7.026075267528186 24.4828747388923 1.248403351071648 0.9974078182800091 0.34850005420540264 0.14324134916585293 564.180877275022 529725.0967111868 0.052972482882030374 0.04119608443457013 9.41726371886625e-08 7.026075267528186 -0.2509955327916388 YS(ph)SPPASTTR ddPTM_A459_Selumetinib_30min_R2 1 YSSPPASTTR 10 0 Q08999;F5H837 Q08999 RBL2 Retinoblastoma-like protein 2 1 YS(0.898)S(0.075)PPAS(0.006)T(0.02)TR 95.483 0.022718 12302000.0 51145.0 49023.0 60300.0 64673.0 64943.0 46109.0 47661.0 50541.0 45416.0 54983.0 True False 48302.56564965685 52782.906466210436 56420.363649675906 55864.42583285219 56784.27974221369 52460.09621417218 49877.33093847982 50688.065942487 54500.46902906503 53395.49792700968 0.9046186949260264 0.9885272825503633 1.0566502016106516 1.04623850327639 1.0634656843136174 0.9824816370452024 0.9341111680737745 0.9492947516244971 1.0206940874222359 1.0 15.704430484904432 -6.983075305592597 24.92370567978847 0.969870532800867 1.015793228719224 0.10770505199726355 0.048130024120727824 454.1249415823547 668752.6077333508 0.018074499643301732 0.015936824325308824 1.0397398618683606e-07 6.983075305592597 0.04592269591835696 YS(ph)SPTAGSAK ddPTM_A459_Selumetinib_30min_R2 2 YSSPTAGSAK 10 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 YS(0.979)S(0.021)PTAGSAK;Y(0.005)S(0.605)S(0.38)PT(0.009)AGSAK 104.07 0.013546 49282100.0 104608.0 97970.0 104253.0 126712.0 125510.0 89132.0 93936.0 104180.0 77112.0 115997.0 True False 98794.30613900296 105483.9839767992 97545.47548208387 109453.60700960805 109742.31172636378 101409.12394026319 98304.21013065276 104483.14655207263 92536.55468930025 112647.86521359954 0.8770188938039095 0.9364046427048005 0.8659327480118779 0.971643863841231 0.9742067594292504 0.9002312094239355 0.8726682032034183 0.9275199876531597 0.8214674509262575 1.0 16.78146044779767 -6.960705742180384 24.99756494409408 0.8975274315951766 0.9262020021724177 0.02858106331939292 0.053224202317123645 484.236277170237 308052.1462489883 0.018169838322666068 0.016024269577532384 1.0946978315846331e-07 6.960705742180384 0.0286745705772411 YS(ph)SSGSPANSFHFK ddPTM_A459_Selumetinib_30min_R2 1 YSSSGSPANSFHFK 14 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 Y(0.001)S(0.71)S(0.263)S(0.019)GS(0.005)PANS(0.002)FHFK 87.088 0.014886000000000003 4902400.0 26940.0 22956.0 37496.0 41406.0 41550.0 24800.0 26915.0 29899.0 30741.0 34373.0 True False 25442.782649364664 24716.65138482602 35083.54818255802 35766.431370665945 36330.11753828706 28215.9748880147 28166.600831060703 29986.001139954085 36890.0589753058 33380.56217822059 0.7622035396984718 0.740450422999544 1.051017295492062 1.0714748055981522 1.0883614645049604 0.8452815964383138 0.8438024704520471 0.8983072537801261 1.1051359404418601 1.0 15.026720631580735 -5.252087569290429 24.674026279729485 0.9806203598053057 0.7513269382177556 0.5126277612273731 0.09205752370224397 502.9195102604491 1326905.8002050503 0.026120903106571135 0.06705718571377514 5.596447457336345e-06 5.252087569290429 -0.22929342158755006 YSCPES(ph)PSQELGGPLPSPGPR ddPTM_A459_Selumetinib_30min_R1 3 YSCPESPSQELGGPLPSPGPR 21 0 A0A494BZV2;A0A1W2PPU9 A0A494BZV2 1 YSCPES(0.857)PS(0.143)QELGGPLPSPGPR;YSCPES(0.896)PS(0.104)QELGGPLPSPGPR;YSCPES(0.998)PS(0.002)QELGGPLPSPGPR 252.66 3.5905e-39 61933000.0 6655.65 6888.950000000001 7209.21 7887.09 7382.84 5693.18 5923.13 5162.2 2407.5299999999997 5484.15 True False 6810.713695359521 6082.388531414032 6230.238879355939 6509.757790515603 6715.0634255462655 5635.911778193852 5476.343535360679 5025.281686811212 4085.4025709659322 6188.094072644686 1.100615733278395 0.9829179162453363 1.00681062799248 1.0519810646209913 1.0851585878810601 0.9107669844755866 0.8849806533435881 0.8120887672063932 0.6602036948704467 1.0 12.595279413754524 -7.1292666322608635 1.8545289597322614 0.8113469996806512 1.0397629481636372 0.5561127721808312 0.0860803186857267 0.24960232759798756 1.6928841917811175 0.04081012902990939 0.028367697197072727 7.425631061526968e-08 7.1292666322608635 0.22841594848298608 YSCPES(ph)PSQELGGPLPSPGPR ddPTM_A459_Selumetinib_30min_R2 1 YSCPESPSQELGGPLPSPGPR 21 0 A0A494BZV2;A0A1W2PPU9 A0A494BZV2 1 YSCPES(0.82)PS(0.18)QELGGPLPSPGPR 164.74 1.1468e-08 27352000.0 103620.0 110320.0 119120.0 137330.0 148150.0 102400.0 104060.0 109610.0 84296.0 98788.0 True False 97861.21522372562 118781.18926529045 111455.9488880495 118625.41709253642 129538.07252219554 116504.6705053509 108898.99619097816 109928.94695308756 101157.55542703165 95935.73375795103 1.0200705346209435 1.2381329105688528 1.1617772077425965 1.236509196790345 1.3502588394124788 1.2144032879270614 1.1351244413862915 1.145860282159741 1.0544304136168432 1.0 16.549780664168082 -8.15978496410837 1.253979398337128 1.0030341179443396 1.20738292987382 0.42288717375624485 0.07897560470954798 0.4314489406033183 1.276943607474187 0.07593458248889483 0.024851893346425083 6.92173607844957e-09 8.15978496410837 0.2043488119294803 YSCPESPSQELGGPLPS(ph)PGPR ddPTM_A459_Selumetinib_30min_R1 1 YSCPESPSQELGGPLPSPGPR 21 0 A0A494BZV2;A0A1W2PPU9 A0A494BZV2 1 YSCPESPSQELGGPLPS(1)PGPR 174.81 2.4883e-11 18822000.0 499.91 675.26 807.4 818.5 805.57 860.68 1092.1 869.0 586.24 636.26 True False 511.55693034447086 596.2002452801431 697.7595147307381 675.5643401478894 732.7063357349348 852.0223406349141 1009.7220177452456 845.9512970901835 994.8064627244802 717.9301686972294 0.7125441340245562 0.8304432259226828 0.9719044346567949 0.9409889284549529 1.0205816215587074 1.1867760651164878 1.4064348620110332 1.1783197502693943 1.3856590878882775 1.0 9.48769971324691 -6.212564188852234 0.8932880426462805 1.265213447349244 0.7805071095044895 0.6840962568792328 0.12009138662812233 0.3396610397501308 0.5749813648603205 0.05800693882009043 0.10048902416551456 6.129651890190744e-07 6.212564188852234 -0.4847063378447545 YSCPESPSQELGGPLPS(ph)PGPR ddPTM_A459_Selumetinib_30min_R2 2 YSCPESPSQELGGPLPSPGPR 21 0 A0A494BZV2;A0A1W2PPU9 A0A494BZV2 1 YSCPESPSQELGGPLPS(1)PGPR;YSCPESPSQELGGPLPS(1)PGPR 205.25 2.3848e-17 31065000.0 36022.0 32411.9 38573.0 37794.0 43603.0 29075.0 37443.0 45306.0 48904.0 66827.0 True False 34020.04144749123 34897.788509315345 36091.25517510696 32646.3920017135 38125.201324234185 33079.81733342853 39184.17369189697 45437.832959187945 58686.16649192788 64897.530872602016 0.524211645498112 0.5377367681032723 0.5561267846377144 0.5030452093131316 0.5874676711364626 0.509723819822457 0.6037852775757833 0.70014732992516 0.9042896656135124 1.0 15.985875969243567 -8.155862960828804 1.403812409444184 1.0027301596721065 0.5372049654871918 0.9783300779919193 0.02435355799525452 0.04848551870434497 0.17605614561020558 0.02107505350367818 0.00671677961462877 6.984527621337282e-09 8.155862960828804 -0.4655251941849148 YSDASDDS(ph)FSEPR ddPTM_A459_Selumetinib_30min_R2 1 YSDASDDSFSEPR 13 0 Q9NRF8 Q9NRF8 CTPS2 CTP synthase 2 1 YSDAS(0.001)DDS(0.997)FS(0.002)EPR 113.69 0.005100899999999999 0.0 11225.0 11625.0 14303.0 16424.0 14033.0 9954.4 14035.0 12608.0 14389.0 11101.0 True False 10601.159437235274 12516.600119733512 13382.76055192893 14187.022867019701 12270.049083388276 11325.528242953773 14687.6553098249 12644.687192633231 17267.202062251567 10780.485286138159 0.9833656979121833 1.1610423638189735 1.2413875810522972 1.315991116398235 1.13817223971962 1.050558295136903 1.3624298832549484 1.1729237466602838 1.601709162801252 1.0 13.396134502365904 -7.273720820951685 24.485304896529062 1.2986760080168105 1.1603702317686926 0.13389368661105838 0.16600566200785322 1202.9658965367532 2398320.990703737 0.0668870894395951 0.04549360553202018 5.3245042625584096e-08 7.273720820951685 -0.1383057762481179 YSDEQLNSGRQSPS(ph)QNER ddPTM_A459_Selumetinib_30min_R1 1 YSDEQLNSGRQSPSQNER 18 1 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7 P25054-2 APC Adenomatous polyposis coli protein 1 YSDEQLNS(0.118)GRQS(0.358)PS(0.524)QNER 130.77 0.0026838 4517000.0 852.16 1106.2 1431.9 1486.6 1433.7 1131.7 895.69 848.91 520.91 522.82 True False 872.0136699852851 976.6855897415718 1237.4558448636903 1226.9932169381216 1304.0220881402931 1120.316125501386 828.1273821758444 826.3941491516998 883.9462242388944 589.9290396980566 1.47816705282318 1.655598426281013 2.0976350740371372 2.079899673299917 2.210472786367206 1.899069294969438 1.4037745668524895 1.400836530398085 1.4983941537974204 1.0 9.204397618431306 -7.274942751144958 4.630706626312242 1.3515533276883984 1.9255460565373805 0.589754490390993 0.23569306680311478 0.16053307096865835 9.43452723861445 0.1068952616070385 0.07456815270516402 5.30954430222345e-08 7.274942751144958 0.5739927288489821 YSDVEVPASVTGYSFAS(ph)DGDSGTCSPLRHSFQK ddPTM_A459_Selumetinib_30min_R1 1 YSDVEVPASVTGYSFASDGDSGTCSPLRHSFQK 33 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 YSDVEVPASVTGY(0.053)S(0.064)FAS(0.727)DGDS(0.031)GT(0.004)CS(0.009)PLRHS(0.112)FQK 85.76 1.2104e-08 39022000.0 3547.4 3888.1 4593.8 4704.2 4973.8 3811.7 4835.4 3807.8 1214.7 2320.7 True False 3630.0475179611853 3432.879444471348 3969.9871919371635 3882.6997787705586 4523.920668195714 3773.3577587466907 4470.6618849971255 3706.804774522438 2061.2571818221663 2618.584450532267 1.3862632985632077 1.310967627480398 1.5160814046421927 1.482747588293874 1.7276206873053714 1.4409914325962252 1.7072819187055035 1.415575798507844 0.7871646764736514 1.0 11.354571417766877 -8.189077757567722 5.157520360641822 0.8956130970258185 1.5096375984820678 0.7726872821361268 0.13166270375810293 0.0923051280332065 4.474236267207835 0.09803760904867097 0.03464902931076302 6.470267594957832e-09 8.189077757567722 0.6140245014562493 YSDVEVPASVTGYSFASDGDSGTCS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 2 YSDVEVPASVTGYSFASDGDSGTCSPLR 28 0 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 YSDVEVPASVTGYSFASDGDS(0.002)GT(0.023)CS(0.975)PLR;YSDVEVPASVTGYSFASDGDS(0.005)GT(0.008)CS(0.987)PLR 196.72 2.8664999999999997e-40 29606000.0 12462.9 14274.800000000001 15607.2 17344.3 16584.2 12995.5 13604.0 12265.2 7312.1 11722.7 True False 12753.261321418067 12603.499779825528 13487.827964213002 14315.443597833888 15084.16203817832 12864.777068969928 12577.839327356762 11939.88705301556 12408.099645346065 13227.422733767657 0.964153151986356 0.9528311019841117 1.0196867701053032 1.082254940056363 1.1403704517336308 0.9725838001780991 0.950891158505685 0.9026616366115519 0.9380587507549766 1.0 13.691244370007928 -6.987842856628368 24.990664208697464 0.9429264976791633 1.0322808216313653 0.34584981475047816 0.05500800177374891 271.6865899745173 558486.5139446747 0.021704440387772604 0.019128319823198327 1.0283883387210629e-07 6.987842856628368 0.089354323952202 YSDVEVPASVTGYSFASDGDSGTCSPLRHS(ph)FQK ddPTM_A459_Selumetinib_30min_R1 1 YSDVEVPASVTGYSFASDGDSGTCSPLRHSFQK 33 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 YSDVEVPASVT(0.005)GY(0.05)S(0.199)FAS(0.199)DGDS(0.032)GT(0.01)CS(0.024)PLRHS(0.482)FQK 70.819 3.431e-05 35353000.0 5979.4 6465.2 7520.1 7912.9 8629.1 6980.0 7484.0 6120.9 2084.3 4160.3 True False 6118.7083861129595 5708.251378410066 6498.91172495247 6531.060558529308 7848.599428591344 6909.787537332926 6919.475854597032 5958.553848514736 3536.9048687510854 4694.315029753687 1.3034294348229993 1.2159923955315757 1.3844217279327908 1.3912701889698265 1.6719370938773923 1.4719479825143917 1.4740118229687922 1.2693127348181796 0.7534442930083175 1.0 12.196698947275799 -8.106748231814647 4.202615677376958 0.8842017848347962 1.4162496262561237 0.7383649449007639 0.12632792398823217 0.12466820999732378 3.6338117930984426 0.10195029046412539 0.035844876300804046 7.820810594056104e-09 8.106748231814647 0.5320478414213275 YSDVEVPASVTGYSFASDGDSGTCSPLRHS(ph)FQK ddPTM_A459_Selumetinib_30min_R2 2 YSDVEVPASVTGYSFASDGDSGTCSPLRHSFQK 33 1 P35611;P35611-3;E7EV99;E7ENY0;P35611-2;P35611-6;P35611-4;H0Y9H2;P35611-5 P35611 ADD1 Alpha-adducin 1 YSDVEVPAS(0.001)VT(0.001)GY(0.002)S(0.004)FAS(0.012)DGDS(0.205)GT(0.154)CS(0.154)PLRHS(0.468)FQK;YSDVEVPASVTGYSFASDGDS(0.026)GT(0.008)CS(0.065)PLRHS(0.901)FQK 84.291 1.416e-08 10647300.0 99223.0 102433.0 118555.0 142515.0 144672.0 93707.0 89088.0 89081.0 88915.0 127457.0 True False 93708.58288113985 110289.28172599262 110927.30037292413 123104.21114791256 126497.00997591014 106614.28866254818 93230.76852452294 89340.21096184649 106700.48449267475 123776.98523694355 0.7570759838895379 0.8910322182663303 0.896186800482969 0.9945646269559473 1.0219752059218417 0.8613417789943647 0.7532156995587939 0.7217837047074986 0.8620381591005821 1.0 16.917383563050358 -6.998295286225854 24.951578287491827 0.8105324104018397 0.9173802597667543 0.10818498826821576 0.09666991255457559 88.80959516791785 1299865.523754574 0.03485921264746698 0.030528361257770108 1.0039329624018177e-07 6.998295286225854 0.10684784936491465 YSEEGLS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 YSEEGLSPSK 10 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 YSEEGLS(1)PSK;YSEEGLS(1)PSK 175.74 5.9036e-05 132440000.0 7667.2 11042.2 10259.4 11567.2 8708.3 8873.9 8864.3 8433.9 5239.6 7783.9 True False 7845.830842225855 9749.374090620488 8866.2298308503 9547.205663236009 7920.635802575232 8784.63662285654 8195.658714311125 8210.205574831874 8891.218514757074 8783.039386606677 0.893293368829704 1.1100228134565104 1.009471714810989 1.087004764864725 0.9018103476404159 1.0001818546154193 0.9331233020324088 0.9347795465145788 1.0123168214770117 1.0 13.100504558043975 -6.26051486089419 24.997540775794807 0.9607360174399707 1.0299194627376211 0.1833348305570056 0.06279070939850341 128.84291718116285 3483710.045215725 0.017853781863167748 0.021734326521329055 5.488897731155745e-07 6.26051486089419 0.06918344529765041 YSEEGLS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 4 YSEEGLSPSK 10 0 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 YSEEGLS(1)PSK;YSEEGLS(0.99)PS(0.01)K;YSEEGLS(0.98)PS(0.02)K;YSEEGLS(1)PSK 181.66 0.00013935 163321000.0 447237.0 399646.0 437193.0 434220.0 429493.0 330384.0 390540.0 425975.0 291995.0 426226.0 True False 422381.357971563 430297.56313557114 409064.47835974756 375078.4869287192 375536.249623864 375891.3970726552 408700.8838403285 427214.5167260425 350402.15902197146 413919.7479118561 1.0204426343570077 1.0395676101619646 0.9882700219629471 0.9061623390063329 0.9072682603774541 0.908126270778221 0.9873916040540328 1.0321191943154582 0.8465461258847435 1.0 18.65899155493269 -5.5287326836213735 4.895535915408851 0.941597246003137 1.0274047917998346 0.32749837702652007 0.05150612360375563 0.210465666087303 14.165329947121247 0.014194579886557224 0.027188031296857276 2.9598337390209367e-06 5.5287326836213735 0.08580754579669758 YSEEGLS(ph)PSKR ddPTM_A459_Selumetinib_30min_R1 2 YSEEGLSPSKR 11 1 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 YSEEGLS(0.85)PS(0.15)KR;YSEEGLS(0.853)PS(0.146)KR 138.2 0.0022806 28457000.0 7678.3 9459.0 10203.1 11100.6 8327.8 8465.7 8769.900000000001 7452.0 5490.5 7157.2 True False 7857.18945062901 8351.535882630205 8817.575061616537 9162.088594069235 7574.551960392502 8380.542744240596 8108.379382313001 7254.348752492577 9316.977489746116 8075.896337031725 0.9729185619434164 1.0341311396401345 1.091838564245045 1.1344980435245082 0.9379208999575284 1.0377229219513289 1.0040222216736892 0.8982716530458703 1.1536772019996664 1.0 12.979406676880496 -6.268619135450038 24.995793525449614 1.0017430787365413 1.059009188241915 0.11020694553706112 0.07346646821308218 1218.3696686548913 4241661.970144309 0.02229999598647225 0.0258441401596954 5.387420376484553e-07 6.268619135450038 0.0572661095053737 YSEWTSPAEDSS(ph)PGISLSSSR ddPTM_A459_Selumetinib_30min_R1 1 YSEWTSPAEDSSPGISLSSSR 21 0 H0YNU5;A0A3B3IT82;P54132 H0YNU5 BLM Bloom syndrome protein 1 YSEWTSPAEDS(0.236)S(0.764)PGISLSSSR 169.6 2.4138e-10 4403200.0 981.41 1081.8 964.95 1007.3 918.53 983.14 820.47 833.27 522.79 884.06 True False 1004.2749435085657 955.1423530848238 833.9150900909412 831.3939643628217 835.4491236796431 973.2505042196985 758.5812873358137 811.1689727575797 887.1364469291265 997.5377124736312 1.0067538609825868 0.9574999933750092 0.8359734972054852 0.8334461484179714 0.8375113173495455 0.9756528420427266 0.7604537431018338 0.8131712341442149 0.8893262237968541 1.0 9.962227574037247 -5.10511477231026 3.7381218544350436 0.8593623843654224 0.9986560385542468 0.30482877228830374 0.06934442143481317 0.25033997709104866 6.141694260653347 0.017459619575526983 0.05777682816032869 7.850281454429115e-06 5.10511477231026 0.13929365418882433 YSGSEGSTQTLTK ddPTM_A459_Selumetinib_30min_R2 1 YSGSEGSTQTLTK 13 0 P25815 P25815 S100P Protein S100-P 0 149.41 0.0072048999999999985 1769300.0 6151.1 5211.0 9143.3 6511.0 9362.7 4646.9 4899.8 6655.4 5967.5 6448.2 False True 5809.246486804265 5610.666943994098 8555.030032472328 5624.190567898516 8186.473922400008 5286.968294641755 5127.650408769507 6674.766112139214 7161.166745881309 6262.023711564372 0.9276947444443652 0.8959830244067292 1.3661765631250093 0.8981426495578514 1.3073208118458037 0.8442906859132557 0.8188487691766536 1.0659119830243713 1.1435866543680515 1.0 12.61241325600861 YSHPGETDGTR ddPTM_A459_Selumetinib_30min_R2 1 YSHPGETDGTR 11 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 0 95.618 0.029568 1099400.0 5782.7 4397.1 6552.2 6367.1 6567.1 5331.4 4470.9 5584.4 4557.6 5675.9 False True 5461.320683982219 4734.343431095077 6130.638585495959 5499.889996139863 5742.082187381109 6065.751956369418 4678.8057089202775 5600.649679452809 5469.24734998386 5512.0220192407505 0.9908016812919924 0.8589122856492517 1.1122304236259961 0.9977989886363773 1.0417378898954486 1.1004585858321627 0.8488365417605418 1.0160789742680068 0.9922397499306829 1.0 12.42836593594558 -5.24691639627169 24.99108823115598 1.011894805657592 0.9248569985274208 0.1868082636380619 0.074047828963134 1374.1185315341 2364568.0681515844 0.018657601807678927 0.04894841601352162 5.663483032544208e-06 5.24691639627169 -0.08703780713017129 YSHS(ph)GSSS(ph)PDTK ddPTM_A459_Selumetinib_30min_R1 1 YSHSGSSSPDTK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 2 YS(0.001)HS(0.999)GS(0.371)S(0.229)S(0.395)PDT(0.005)K 138.89 0.021894 5263600.0 2254.0 3132.6 3023.7 3229.6 3522.6 3234.2 2687.4 3347.6 1302.5 2344.6 True False 2306.5138144794805 2765.8337356937714 2613.098147995209 2665.6109871003364 3203.981451965543 3201.666884418646 2484.6872543618483 3258.810773462712 2210.247369163886 2645.5522483379805 0.8718458748748982 1.0454655497472618 0.9877325800829826 1.0075820610894974 1.211082281205516 1.2102073910768667 0.939194172378492 1.2318073761385737 0.8354578408165756 1.0 11.36935319519651 -3.822428448129469 0.949533923294092 1.0734647373612267 4.280705555117335e-09 0.15123513854755954 0.12372751386325183 18.720887524811925 3.4217069919930276 0.03924169099760844 31.77474794895628 0.00015051214735664815 3.822428448129469 -1.0734647330805211 YSHS(ph)GSSSPDTK ddPTM_A459_Selumetinib_30min_R2 1 YSHSGSSSPDTK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 YS(0.001)HS(0.952)GS(0.009)S(0.009)S(0.029)PDTK 106.54 0.0088575 1493200.0 3580.7 4388.4 4854.4 6222.4 5172.7 3832.7 4763.1 6855.7 4600.4 6999.8 True False 3381.699028677802 4724.976169069982 4542.07318907109 5374.8983857612875 4522.859181475271 4360.619635213463 4984.593587903595 6875.648951977771 5520.608545915772 6797.6975863354555 0.497477121588286 0.6950847855556267 0.6681781781821894 0.7906939544597806 0.6653516317888277 0.6414847939071401 0.7332767491633473 1.011467318846165 0.8121291769456098 1.0 12.730830465841647 -7.628021101159452 5.029333565938477 0.9319949300283664 0.6693437447746727 0.6873311304185532 0.08462802712403386 0.12397804549768963 5.002441455345346 0.04065195231869701 0.022792017223653652 2.3549348613894073e-08 7.628021101159452 -0.2626511852536937 YSHS(ph)YLSDSDTEAK ddPTM_A459_Selumetinib_30min_R1 1 YSHSYLSDSDTEAK 14 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 YSHS(0.995)YLS(0.004)DS(0.001)DTEAK 222.56 4.7968e-09 36865000.0 5395.3 5964.9 6067.2 6872.4 6761.6 4968.9 5670.4 6231.3 2781.6 5619.1 True False 5520.999992573708 5266.526734993223 5243.307564744034 5672.264350925301 6150.014473857442 4918.917377400225 5242.67716273477 6066.025681884995 4720.172039974101 6340.366219669 0.8707698895130908 0.8306344700808407 0.8269723519247696 0.894627243033514 0.9699777995124238 0.7758096625618918 0.8268729251744176 0.9567311211562276 0.7444636281941011 1.0 12.630350457525427 -10.608936231883117 4.455235888467023 1.0000110022988014 0.8580059661891543 0.28957513073984975 0.06791025582228309 14062674.402689658 33486446.138604097 888.0901450695184 0.015977318368570758 2.4607288901746833e-11 10.608936231883117 -0.1420050361096471 YSHSGSSS(ph)PDTK ddPTM_A459_Selumetinib_30min_R1 3 YSHSGSSSPDTK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 YSHSGSSS(0.999)PDTK;YSHSGS(0.003)S(0.007)S(0.99)PDTK;YSHSGS(0.013)S(0.008)S(0.979)PDTK 184.98 8.4977e-09 26615200.0 12023.83 19623.19 17670.739999999998 12223.33 12620.14 15919.349999999999 10549.49 16865.96 13684.85 11443.699999999999 True False 12303.961844699561 17325.697792226467 15271.150566426857 10088.754875821513 11478.650565266678 15759.215792613319 9753.733475856872 16418.61995244091 23222.190948101652 12912.61036607752 0.9528640217490858 1.3417657081748928 1.1826540206421323 0.7813102532951427 0.888948883288698 1.2204515853753368 0.7553649648935993 1.2715182667924343 1.7984118075078173 1.0 13.656493059630085 -7.994113933758961 24.947279922038934 1.4444589674569956 1.0290032428592184 0.2778556695624621 0.25348568099250623 158.38353009216058 671286.8954156004 0.13518844829477705 0.06464806553125547 1.0136454289058874e-08 7.994113933758961 -0.41545572459777724 YSHSGSSS(ph)PDTK ddPTM_A459_Selumetinib_30min_R2 3 YSHSGSSSPDTK 12 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L182 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 YSHSGSS(0.037)S(0.963)PDTK;YSHS(0.003)GS(0.071)S(0.071)S(0.856)PDTK;YSHSGSSS(0.999)PDTK 246.63 3.4058999999999997e-18 17711300.0 41430.0 33420.7 42091.0 34912.1 41778.9 56264.0 97000.0 260358.0 72553.0 168779.0 True False 39127.48645743051 35983.960225512084 39382.91088521574 30157.011753268274 36530.26107389514 64013.855286260405 101510.69220185367 261115.5986754131 87065.62730019739 163905.91172949405 0.23871918983621207 0.2195403438827701 0.2402775499044369 0.1839897745911606 0.2228733587973551 0.390552449333903 0.6193229465047253 1.5930822501774757 0.5311927213698563 1.0 17.32250836468269 -7.4250234391398635 3.083509167234059 1.0542304831193243 0.2402766970318208 0.6636649874836962 0.2499365256364472 0.14081084545139422 2.5639972696003537 0.11097292216172322 0.06790767071067152 3.758171206603195e-08 7.4250234391398635 -0.8139537860875035 YSHSYLS(ph)DSDTEAK ddPTM_A459_Selumetinib_30min_R1 1 YSHSYLSDSDTEAK 14 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 YSHS(0.046)YLS(0.951)DS(0.003)DTEAK 315.32 1.666799999999999e-94 33393000.0 2939.1 3858.9 3395.5 3408.4 3655.8 2920.4 3622.9 3360.4 1290.2 2732.4 True False 3007.57531150694 3407.0981940460606 2934.409750146421 2813.18692359202 3325.133535483913 2891.0234275110433 3349.621736186477 3271.2712758824528 2189.3751675203403 3083.1301558298646 0.9754941113400424 1.105077639230899 0.9517631763283723 0.912445074131103 1.078492754902496 0.9376910092635666 1.0864353974329322 1.0610227627584368 0.7101144151765599 1.0 11.590180079461286 -8.236565719533703 24.991079750006442 0.8550571083472971 1.0132390316910758 0.3251463890386438 0.09133515444835764 726.9111082627252 730344.9471596677 0.058287323963558034 0.02201090826206133 5.80008396216148e-09 8.236565719533703 0.15818192334377867 YSHSYLS(ph)DSDTEAK ddPTM_A459_Selumetinib_30min_R2 2 YSHSYLSDSDTEAK 14 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 YSHSYLS(0.659)DS(0.341)DTEAK;YSHS(0.375)YLS(0.619)DS(0.007)DTEAK 261.45 6.96e-36 34876000.0 125955.0 94813.0 112858.0 118940.0 107180.0 73355.0 83146.0 104001.0 74639.0 83309.0 True False 118954.92533781473 102084.8522281543 105596.83915049977 102740.16681705549 93715.09019864269 83458.98539960968 87012.45375067336 104303.62569170767 89568.88558790684 80903.65270722298 1.470328240534368 1.2618077035110218 1.3052172011644192 1.2699076417334982 1.158354253024671 1.0315848865518351 1.0755071104830969 1.289232589647903 1.107105582884396 1.0 16.30391721970326 -1.522878745284079 0.3080979672326213 1.0833654902362102 4.347410344046576 0.6581548996056988 0.08163451969363651 38.381596193010395 0.5478941212118064 0.08631096881367915 69.67855407541094 0.029999999999741546 1.522878745284079 3.2640448538103657 YSHSYLSDS(ph)DTEAK ddPTM_A459_Selumetinib_30min_R2 1 YSHSYLSDSDTEAK 14 0 Q92614;A0A0D9SFK2;Q92614-3;Q92614-4;Q92614-2;Q92614-5 Q92614 MYO18A Unconventional myosin-XVIIIa 1 YSHSYLS(0.168)DS(0.816)DT(0.016)EAK 120.29 0.0020885 22946000.0 62505.0 45988.0 56508.0 63871.0 56043.0 37782.0 46129.0 51747.0 35366.0 53020.0 True False 59031.22232733995 49515.13172527356 52872.336801258476 55171.65961637937 49002.377309223164 42986.127549152065 48274.089902879416 51897.575202823005 42440.18820860302 51489.17483749616 1.1464783134250467 0.9616610070281213 1.0268631604240634 1.0715195920405682 0.9517025173520158 0.8348575731660028 0.9375580411850879 1.0079317714182794 0.8242545805511071 1.0 15.651981529323754 -6.391279285366483 4.919929688027664 0.9197670195371057 1.0428219554100446 0.435304646727687 0.07032913424679721 0.22902322685108356 8.197020066002072 0.02165102773734031 0.02456666605334985 4.0618203829553735e-07 6.391279285366483 0.12305493587293892 YSISLS(ph)PPEQQK ddPTM_A459_Selumetinib_30min_R2 1 YSISLSPPEQQK 12 0 A0A0U1RQT1;A0A087X1H5;Q15057;H7C3K3 A0A0U1RQT1 ACAP2 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 1 YSISLS(1)PPEQQK 157.33 0.00044373 7239800.0 36405.0 21643.0 30090.0 32156.0 28017.0 26459.0 28441.0 31173.0 26621.0 26122.0 True False 34381.755840761725 23302.94850678646 28154.042159514895 27776.297327805976 24497.253984842107 30103.48707911212 29763.562854772357 31263.708269032024 31945.943852887543 25367.789986893153 1.3553311446730616 0.9186038089572035 1.1098342494187048 1.0949435225597985 0.9656834118186556 1.1866815002278785 1.1732816642738835 1.2324174981417433 1.2593112710801038 1.0 14.630710218469263 -6.888622836679598 21.836184490890506 1.1850948006317061 1.0804307572501577 0.08737768966162895 0.12575824864396754 7.049016645332646 1346.1366457345864 0.04198879343919233 0.037030683236863024 1.2923411208810063e-07 6.888622836679598 -0.10466404338154844 YSLQSANASSLS(ph)SGQLKSPSLSQSQASR ddPTM_A459_Selumetinib_30min_R2 1 YSLQSANASSLSSGQLKSPSLSQSQASR 28 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 YS(0.001)LQS(0.003)ANAS(0.163)S(0.163)LS(0.358)S(0.272)GQLKS(0.018)PS(0.009)LS(0.011)QS(0.003)QASR 46.347 0.025653 6806400.0 4158.7 3741.3 3555.9 4098.9 7101.0 3057.3 4940.4 4525.7 4044.2 5037.5 True False 3927.5761025951288 4028.24567982443 3327.117265371187 3540.622749003108 6208.908896254547 3478.4153235938434 5170.138389216881 4538.869037730031 4853.153004389307 4892.054286003152 0.8028480210925849 0.8234262018207364 0.6801063665402349 0.7237496851033158 1.2691823379840856 0.7110336722031221 1.0568440346235253 0.9278043072245471 0.9920480682879692 1.0 12.256224697871826 YSLQSANASSLSSGQLKS(ph)PSLSQSQASR ddPTM_A459_Selumetinib_30min_R2 1 YSLQSANASSLSSGQLKSPSLSQSQASR 28 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 1 YSLQSANAS(0.036)S(0.036)LS(0.036)S(0.036)GQLKS(0.636)PS(0.186)LS(0.028)QS(0.003)QAS(0.003)R 62.032 0.0015044 10412000.0 3918.2 1240.3 4126.6 6542.9 4320.0 1930.8 1521.0 1419.1 4257.2 2423.2 True False 3700.4421297973518 1335.4270218069237 3861.099048702367 5651.7457328679475 3777.2829787099945 2196.750173942693 1591.7295138043237 1423.2293460553476 5108.758956106563 2353.23591977029 1.5724909256690969 0.5674853976975164 1.6407615642205846 2.4016910864677095 1.6051441961155821 0.9335018879692809 0.6764003134712051 0.6047967116676833 2.1709506102580876 1.0 11.200430247477144 -6.7586077579560015 24.967974692675174 1.0273840655909616 1.554036592832189 0.14526830540796465 0.5763118246821478 147.41675493230355 1299857.1759273193 0.20541611440295623 0.19678884943540267 1.7433807329206377e-07 6.7586077579560015 0.5266525272412275 YSLS(ph)PSK ddPTM_A459_Selumetinib_30min_R1 2 YSLSPSK 7 0 P49792;Q99666;O14715;J3KQ37;F8W705;Q99666-2 P49792;Q99666 RANBP2;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 YSLS(1)PSK;YSLS(0.976)PS(0.024)K 131.62 0.0038767 170072000.0 13129.6 16826.4 15733.7 16895.2 16095.0 16784.2 16160.6 16796.0 9130.5 14524.7 True False 13435.494134245697 14856.357265618864 13597.149959027767 13944.770482182814 14639.21009180304 16615.366186834275 14941.592931026305 16350.515518903014 15493.791634664765 16389.086727558926 0.8197829664085772 0.9064786533002651 0.8296465925806347 0.8508570803237075 0.8932291551784032 1.013806715592935 0.9116794107814074 0.9976465309326203 0.9453724842770717 1.0 14.000447842874463 -6.579279016256627 5.023056749624589 0.9693382072298967 0.8557503331896876 0.7316549501053937 0.03503054376366065 0.10410676888020087 5.477231510539004 0.011021193223495514 0.011120629022549672 2.634638195821636e-07 6.579279016256627 -0.11358787404020909 YSLS(ph)PSK ddPTM_A459_Selumetinib_30min_R2 1 YSLSPSK 7 0 P49792;Q99666;O14715;J3KQ37;F8W705;Q99666-2 P49792;Q99666 RANBP2;RGPD5;RGPD8 E3 SUMO-protein ligase RanBP2;RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 YSLS(0.973)PS(0.027)K 101.46 0.019909 247690000.0 329840.0 320430.0 352720.0 321710.0 362330.0 277630.0 309420.0 281860.0 250970.0 315960.0 True False 311508.81325413624 345005.9506551578 330026.3792124997 277892.5430192954 316810.8661287017 315871.012425787 323808.64310409833 282680.16593556525 301171.01268769725 306837.41383733077 1.0152243475082932 1.124393359794324 1.0755741129647982 0.9056670747675495 1.03250402930543 1.029440994419427 1.055310169169151 0.9212702010499527 0.9815328871444682 1.0 18.227114881223713 -5.589672609813438 24.999894850923372 0.9921897816114357 1.0773535098037932 0.35360010943946774 0.05075449701900919 56.44509013083889 21125.78193884666 0.01392307310614276 0.024115468343133113 2.572334190134937e-06 5.589672609813438 0.08516372819235751 YSPPAIS(ph)PLVSEK ddPTM_A459_Selumetinib_30min_R1 2 YSPPAISPLVSEK 13 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 YS(0.173)PPAIS(0.827)PLVSEK;YSPPAIS(1)PLVSEK 184.01 0.00012208 88278000.0 3957.9 4916.6 4878.700000000001 5418.5 4433.4 3935.4 4552.299999999999 3544.4 2270.5 3188.2 True False 4050.111369267228 4340.962186334669 4216.19933678084 4472.260692842202 4032.399752780345 3895.8134490573057 4208.916345922241 3450.390998166221 3852.872669241155 3597.4365256978354 1.1258326145119635 1.2066820791209385 1.1720010364777669 1.2431798756962549 1.1209092152079416 1.082941539406756 1.1699765418670702 0.9591249139543636 1.0710050453200894 1.0 11.812753516486914 -7.36962838403343 0.861449726186837 1.005057144471425 1.1844709094680492 0.5857939042437312 0.05451333121397721 0.41439717767138406 0.5851993390159256 0.04322183615660518 0.023490570361064778 4.269446894605676e-08 7.36962838403343 0.17941376499662431 YSPPAIS(ph)PLVSEK ddPTM_A459_Selumetinib_30min_R2 3 YSPPAISPLVSEK 13 0 Q14694;Q14694-3;Q14694-2 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 Y(0.001)SPPAIS(0.98)PLVS(0.018)EK;YSPPAIS(1)PLVSEK;YSPPAIS(0.998)PLVS(0.002)EK 153.79 0.00040206 39958000.0 143579.0 134924.0 141629.0 150596.0 166985.0 131093.0 137448.0 133265.0 118882.0 142412.0 True False 135599.45397227653 145272.23695096144 132516.744333996 130084.56500740997 146006.85143515925 149149.8708062302 143839.60434804522 133652.77908679174 142661.72184061387 138300.19552918748 0.9804718890918634 1.050412375738851 0.958181901529048 0.9405956695119521 1.0557241143187344 1.0784501803162887 1.0400535140074236 0.9663961686777591 1.0315366604850962 1.0 17.07744367061278 YSPS(ph)QNSPIHHIPSR ddPTM_A459_Selumetinib_30min_R1 1 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 YS(0.008)PS(0.957)QNS(0.035)PIHHIPSR 128.44 0.00064156 36429000.0 2190.5 2802.5 1877.6 1868.3 2170.8 2141.0 2940.5 1966.1 818.68 1755.7 True False 2241.5343880289724 2474.381997153097 1622.632232918545 1542.0364773345184 1974.451523285868 2119.4634838724637 2718.695717589868 1913.9526412071461 1389.240165978571 1981.061196966217 1.131481648048855 1.2490184558368758 0.8190722403747206 0.7783891177597048 0.9966635691565354 1.0698627014239614 1.372343126882329 0.9661249456292211 0.7012606011899296 1.0 10.95205773187384 -8.005651230510969 24.985418055959975 0.8449844110251337 1.0536416577005445 0.1764235118782297 0.18021779802977758 431.26636540045854 1906718.861048133 0.11151687931181634 0.05092938589066222 9.870718566271687e-09 8.005651230510969 0.20865724667541086 YSPSQNS(ph)PIHHIPSR ddPTM_A459_Selumetinib_30min_R2 4 YSPSQNSPIHHIPSR 15 0 E9PK91;Q9NYF8-3;A0A1W2PQ43;E9PQN2;E9PKI6;E9PK09;E9PJA7;H0YF00;Q9NYF8-2;Q9NYF8;Q9NYF8-4 E9PK91;Q9NYF8-2 BCLAF1 Bcl-2-associated transcription factor 1 1 Y(0.001)S(0.006)PS(0.07)QNS(0.923)PIHHIPSR;Y(0.001)S(0.001)PS(0.001)QNS(0.997)PIHHIPSR;YS(0.007)PS(0.033)QNS(0.96)PIHHIPSR;YS(0.007)PS(0.143)QNS(0.85)PIHHIPSR 108.12 0.0026923000000000003 136420200.0 85878.0 75784.2 96297.0 105738.0 113631.0 89033.0 86126.0 86048.0 73176.0 96995.0 True False 81105.24455687219 81596.6044553901 90101.35586024624 91336.30199177595 99355.6579059711 101296.48758889564 90131.02965543143 86298.38543398674 87813.24470827146 94194.50232672461 0.8610401090665482 0.8662565483106728 0.9565458029357083 0.9696563996374793 1.0547925351454632 1.0753970251632836 0.9568608297626696 0.9161722107161916 0.9322544579478852 1.0 16.52335523877788 -5.347519000446387 2.356050765986835 0.9881074731721416 0.8568142678435672 0.5180055765987026 0.04671514779597844 0.28458550800545 2.99731761280471 0.015121975109783777 0.04530198435063831 4.492426698085754e-06 5.347519000446387 -0.13129320532857447 YSPT(ph)SPTYSPT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 3 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 YS(0.001)PT(0.978)S(0.021)PT(0.003)Y(0.001)S(0.001)PT(0.862)S(0.133)PK;YS(0.011)PT(0.909)S(0.08)PTYSPT(0.715)S(0.285)PK;YS(0.043)PT(0.847)S(0.109)PT(0.002)Y(0.005)S(0.043)PT(0.78)S(0.169)PK 163.62 0.0013022 71479000.0 13876.9 15074.9 17312.6 18301.300000000003 13405.0 14158.599999999999 14184.0 13349.8 9673.3 14058.300000000001 True False 14200.204770253007 13309.923699869118 14961.64401130465 15105.321512948782 12192.520116844978 14016.177338980226 13114.089460396093 12995.719937738237 16414.88359012131 15862.819744438206 0.8951879299537434 0.8390641710806693 0.9431894362003626 0.9522469369448003 0.7686224967108952 0.883586749694647 0.8267186837947984 0.8192566105590888 1.034802377797722 1.0 13.953361624092818 -8.268423456857239 24.993323456205268 1.0174012147331981 0.8665682500648213 0.557602216545227 0.05394644651527295 458.38261587319425 1640352.2277743837 0.04962835540315758 0.013935760485729242 5.389848315157506e-09 8.268423456857239 -0.1508329646683768 YSPT(ph)SPTYSPT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 YS(0.005)PT(0.97)S(0.025)PTYS(0.038)PT(0.958)S(0.003)PK 194.77 0.00099934 19651000.0 42980.0 40004.0 40526.0 38131.0 42111.0 33508.0 40977.0 40474.0 27881.0 36284.0 True False 40591.34366257212 43072.17816686622 37918.60128137257 32937.49202035608 36820.639702883425 38123.42284466117 42882.51169438509 40591.7726391686 33457.97906022907 35236.38664284629 1.1519723652144962 1.2223778392331484 1.0761205927756732 0.9347579351483551 1.044960712802224 1.0819333784442111 1.2169951513201231 1.1519845394649613 0.9495292295250631 1.0 15.10477836851485 -5.314064037839592 7.332316088546033 1.0639697144925042 1.1869538031767686 0.28129044386125046 0.08266123552679704 0.3454400301953255 42.44731841038786 0.02340227713459207 0.04947036212693391 4.852169483986113e-06 5.314064037839592 0.12298408868426436 YSPT(ph)SPTYSPTSPK ddPTM_A459_Selumetinib_30min_R1 1 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YS(0.001)PT(0.32)S(0.32)PT(0.072)Y(0.237)S(0.044)PT(0.002)S(0.002)PK 168.0 0.0004775000000000001 53941000.0 3299.2 4254.9 4435.5 4353.3 4061.7 3690.4 3849.4 3526.7 2219.4 3285.7 True False 3376.064940874312 3756.734329950656 3833.1834624575044 3593.07787656177 3694.3199521513784 3653.277926615104 3559.036658830279 3433.1604596639227 3766.1597014374893 3707.451600428263 0.9106160524076238 1.0132928854733263 1.0339132848058536 0.9691503123457414 0.9964580391891379 0.9853878945292499 0.9599684749543757 0.9260162585176686 1.0158351631623308 1.0 11.856212143551595 -7.132701746992829 6.300270953881164 0.9693827388138926 0.9883881169232721 0.0 0.037739444484313926 0.8437750113964937 39.63273543079626 0.014394940194408401 0.011129821585346332 7.36712863523013e-08 7.132701746992829 0.019005378109379523 YSPTS(ph)PK ddPTM_A459_Selumetinib_30min_R1 3 YSPTSPK 7 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPT(0.169)S(0.831)PK;YSPT(0.131)S(0.869)PK;YSPT(0.116)S(0.884)PK 109.48 0.015825 409690000.0 40809.0 47480.0 53141.0 55477.0 37310.0 41354.0 42094.0 39264.0 26043.1 37853.0 True False 41759.77029950893 41921.019527146855 45924.74408261848 45788.98338226571 33935.3170876155 40938.01630642776 38918.81568992616 38222.591172553475 44193.23858723375 42711.80126944362 0.9777103530724708 0.9814856381891228 1.0752237722990492 1.0720452432668424 0.7945185189811489 0.9584708462228952 0.911195841271368 0.8948953225229168 1.0346844964098942 1.0 15.382347121071911 -6.213697575455708 24.99983897422397 0.9272925354152399 1.0268646059197704 0.31745536950797026 0.06751625715668075 472.57092121502035 247460.01645436187 0.019755572438306307 0.025504288157655302 6.113676075851312e-07 6.213697575455708 0.09957207050453043 YSPTS(ph)PK ddPTM_A459_Selumetinib_30min_R2 3 YSPTSPK 7 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPT(0.202)S(0.798)PK;YSPT(0.133)S(0.867)PK;YSPT(0.084)S(0.916)PK 110.41 0.015429 407896000.0 1966690.0 1726970.0 1620980.0 1635250.0 1489940.0 1277180.0 1548760.0 1538380.0 1122000.0 1498990.0 True False 1857389.2430838542 1859423.0459162297 1516687.9115895806 1412526.129036406 1302760.4169674008 1453099.9519142983 1620780.4088097182 1542856.4311074815 1346431.3512993436 1455710.2638562473 1.2759333290427861 1.2773304496669053 1.0418885881671265 0.970334663502719 0.8949311200955093 0.9982068465087042 1.1133949172798934 1.0598650496702413 0.9249308634621985 1.0 20.47329180776378 -5.302886701919584 3.846021151285876 0.998571051728711 1.2823115144328894 0.783186032066281 0.05849245378723905 0.10274059725453491 3.2475061850949296 0.017293145905694703 0.0424401608603679 4.978669508075037e-06 5.302886701919584 0.2837404627041784 YSPTS(ph)PTYS(ph)PTSPK ddPTM_A459_Selumetinib_30min_R2 2 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 YS(0.003)PT(0.196)S(0.802)PT(0.054)Y(0.013)S(0.795)PT(0.134)S(0.003)PK;YS(0.043)PT(0.247)S(0.71)PT(0.002)Y(0.002)S(0.735)PT(0.237)S(0.024)PK 164.93 0.0046744 72049000.0 174255.0 156519.0 175294.0 171030.0 166572.0 148973.0 175662.0 172283.0 134634.0 142219.0 True False 164570.60469803427 168523.50401209207 164015.7748856767 147735.41895679355 145645.73618742597 169492.67850775045 183830.6310676497 172784.3150070141 161564.56198826752 138112.76794066138 1.1915669141374403 1.2201877243130508 1.187549690960826 1.0696724217435598 1.054542156812041 1.2272049936800276 1.3310183686031873 1.2510379567604422 1.1698017815245145 1.0 17.075487171246472 YSPTS(ph)PTYSPTTPK ddPTM_A459_Selumetinib_30min_R1 2 YSPTSPTYSPTTPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPT(0.067)S(0.918)PT(0.015)YSPTTPK;YS(0.003)PT(0.067)S(0.735)PT(0.19)YS(0.005)PTTPK 219.35 9.2242e-09 124063000.0 6348.299999999999 8599.8 8044.0 8386.0 7412.1 6875.4 7416.9 6844.3 4055.6 7175.0 True False 6496.203038358513 7592.931418061443 6951.668982529175 6921.542524716191 6741.676863712543 6806.239718363722 6857.437261619552 6662.766930580369 6882.056990695625 8095.981140418414 0.8023984895328917 0.9378642670194051 0.8586567658641928 0.854935603809778 0.8327189437306572 0.8406936232082137 0.8470174451598523 0.8229721407473568 0.8500584266850144 1.0 12.982990213941282 -10.581979257257293 7.898688539167315 0.9999999233194278 0.8510825268897887 0.6440578838249468 0.033505729654815734 3.254767421072642e-09 3.964050606144356e-10 0.03232664962607131 0.007840363880313497 2.6183080606792786e-11 10.581979257257293 -0.14891739642963908 YSPTS(ph)PTYSPTTPK ddPTM_A459_Selumetinib_30min_R2 1 YSPTSPTYSPTTPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPT(0.054)S(0.91)PT(0.035)YSPTTPK 134.4 0.00064787 27562000.0 217170.0 181440.0 191580.0 222740.0 220680.0 186730.0 191710.0 191590.0 154740.0 207970.0 True False 205100.56080039067 195355.86457844754 179253.95137653284 192402.42775206818 192956.2054957689 212450.3625338298 200624.8948661585 192147.49518056822 185692.32379684562 201965.3657290468 1.0155234292772255 0.9672740861942316 0.8875479750177404 0.9526506045110323 0.9553925486146746 1.0519148259253988 0.9933628676478784 0.9513883456550165 0.919426571613111 1.0 17.62374838634951 -4.768759506631411 6.2184247290448535 0.9632818860630354 1.0170230392193578 0.11542189975105921 0.04253128368965009 0.293711230323425 47.35898931500642 0.011451332256165903 0.06648382413622779 1.7031013506685984e-05 4.768759506631411 0.05374115315632233 YSPTSPT(ph)YSPT(ph)SPK ddPTM_A459_Selumetinib_30min_R1 1 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 YS(0.005)PT(0.362)S(0.235)PT(0.397)Y(0.001)S(0.008)PT(0.604)S(0.388)PK 178.68 0.0032618 10756000.0 4753.6 6373.8 6040.4 6691.0 4343.4 5292.2 4564.6 5039.7 3453.0 4846.6 True False 4864.349631104548 5627.552532900772 5220.1468575421695 5522.542455625572 3950.5402368895516 5238.965272933143 4220.288547019457 4906.0307847472895 5859.488802858268 5468.708319881793 0.889487854640178 1.0290460203264988 0.9545484147625932 1.0098440312766477 0.7223900061605303 0.9579895226605145 0.7717157873782303 0.8971096093955391 1.0714575472156325 1.0 12.416984400941686 -1.8628630861466369 19.841885182850167 0.9237058276952304 0.11258652388640533 0.0 0.10667783998085452 0.0 0.0 0.02427698941275184 0.0 0.013713140127202421 1.8628630861466369 -0.811119303808825 YSPTSPT(ph)YSPTSPK ddPTM_A459_Selumetinib_30min_R2 2 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPT(0.002)S(0.016)PT(0.801)YS(0.179)PT(0.001)SPK;YSPT(0.001)S(0.071)PT(0.862)Y(0.013)S(0.05)PT(0.003)SPK 147.56 0.0011137 65882000.0 52909.0 46427.0 55803.0 61175.0 57744.0 50213.0 50272.0 57699.0 39091.0 55119.0 True False 49968.52959150832 49987.80161366603 52212.6957337125 52842.859467238784 50489.6824820902 57129.384961769465 52609.74761207816 57866.89453741633 46910.29229379912 53527.57125363922 0.9335101223766261 0.933870161543477 0.9754355467821207 0.9872082410921291 0.9432462803672886 1.0672889433197545 0.9828532544992192 1.081067068468609 0.876376252371245 1.0 15.707994573210716 -5.421846289088256 0.9705684420510048 0.9999333225301339 0.9205077592388398 0.141372352857548 0.05454975494159641 1.6005284783681206 2.2695318221929823 0.019348778526476196 0.10809973657029004 3.7857655153600904e-06 5.421846289088256 -0.07942556329129413 YSPTSPTYS(ph)PTSPK ddPTM_A459_Selumetinib_30min_R1 2 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPTSPT(0.025)YS(0.975)PT(0.001)SPK;YSPT(0.007)S(0.007)PT(0.047)YS(0.891)PT(0.047)S(0.001)PK 230.57 2.4638e-13 85025000.0 15424.1 17581.5 19154.2 19154.3 16982.0 15967.9 17326.7 16195.8 8780.4 14123.8 True False 15783.451519925895 15523.049806582394 16553.16484648935 15809.361075741876 15445.981098415621 15807.277423693178 16019.733069193802 15766.234772627377 14899.697504957061 15936.72730746223 0.9903822293888053 0.9740425061620942 1.0386803091459362 0.9920080058306127 0.9692065880541972 0.9918772605396569 1.0052084571775728 0.9893019105149009 0.9349283085229432 1.0 13.960067774119125 -8.026907282245306 24.59618053418616 0.965681127654036 0.9944478989332382 0.17634527925968513 0.02297479351061939 960.4793616984741 877975.6580219959 0.015068418231240605 0.0057345583471874306 9.399239539996658e-09 8.026907282245306 0.02876677127920213 YSPTSPTYS(ph)PTSPK ddPTM_A459_Selumetinib_30min_R2 1 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPTS(0.001)PT(0.015)YS(0.952)PT(0.026)S(0.005)PK 81.128 0.03255 9983900.0 22658.0 20357.0 23000.0 31441.0 27693.0 23658.0 22890.0 23470.0 18831.0 28721.0 True False 21398.75906716051 21918.316441928182 21520.205040506553 27158.681561249778 24213.95776143884 26916.674754058527 23954.430355674514 23538.29381433234 22597.72618210154 27891.750103880186 0.7672074712939437 0.7858351075244646 0.7715616610774363 0.9737173701936894 0.8681404957113212 0.965040725440674 0.8588356867696901 0.8439159868658722 0.8101939138970644 1.0 14.767550840519272 -5.736443469249167 24.943804541076254 0.8956443920419196 0.7759646783980718 0.4995537455189081 0.05838133407815814 198.06426386878533 197649.77635914867 0.015832727658962167 0.027408405357932944 1.834663964030661e-06 5.736443469249167 -0.11967971364384777 YSPTSPTYSPT(ph)SPK ddPTM_A459_Selumetinib_30min_R2 1 YSPTSPTYSPTSPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPTSPT(0.005)YS(0.134)PT(0.846)S(0.014)PK 152.88 0.00087502 10347000.0 28175.0 24166.0 26020.0 32911.0 30194.0 27734.0 32397.0 27923.0 30181.0 32602.0 True False 26609.146293461385 26019.45449406282 24345.901528433948 28428.465025358328 26400.759782215147 31554.106755814482 33903.52469343762 28004.251307098493 36218.043327598454 31660.695549831198 0.8404473063954293 0.8218219480715592 0.7689629398733708 0.8979103121917957 0.8338654386370834 0.9966334032728702 1.070839541098407 0.8845115630205351 1.143943387806954 1.0 14.950405329758263 -6.783509819314242 4.703091627057632 1.0174900366286754 0.8309871819259925 0.6580332675924061 0.06738292026799113 0.11998369475221358 6.478414498629747 0.022679515087150076 0.02079596148498928 1.6462287449939773e-07 6.783509819314242 -0.1865028547026829 YSPTSPTYSPT(ph)TPK ddPTM_A459_Selumetinib_30min_R1 2 YSPTSPTYSPTTPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPTS(0.006)PT(0.004)YS(0.169)PT(0.794)T(0.027)PK;YSPTS(0.001)PT(0.004)YSPT(0.914)T(0.081)PK 122.64 0.0037644 6775700.0 3298.8 4255.700000000001 4969.200000000001 4668.0 3733.1 3977.1000000000004 4099.2 3545.1000000000004 2420.9300000000003 3400.5 True False 3375.6556216525764 3757.440665578748 4294.409933861757 3852.821429212402 3395.4417641323344 3937.0939849178753 3789.9940437151477 3451.0724318923 4108.141392268659 3836.987298674957 0.8797672128907765 0.9792684658811148 1.1192140081737472 1.004126709135293 0.8849238998797042 1.026089918587296 0.9877525643683945 0.8994224278730537 1.0706684887091862 1.0 11.905758273952811 -8.295844123940476 24.99255033884986 1.0353342223927118 0.9781023374080414 0.10801570546989603 0.07072951216295317 1864.4009918266786 1354335.9069098216 0.06972944371047231 0.0180071621295834 5.060062441086069e-09 8.295844123940476 -0.057231884984670356 YSPTSPTYSPT(ph)TPK ddPTM_A459_Selumetinib_30min_R2 1 YSPTSPTYSPTTPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPTSPTYSPT(0.5)T(0.5)PK 217.46 2.7657e-08 5169700.0 40031.0 32063.0 34321.0 33213.0 35390.0 28329.0 34499.0 39877.0 21535.0 31519.0 True False 37806.23727678976 34522.129001205656 32112.824225879398 28689.332104379257 30943.991809385796 32231.06260494228 36103.2718584716 39993.03546800725 25842.6017381741 30608.96457380311 1.2351361048372895 1.1278437373458772 1.049131346748115 0.9372852856621362 1.0109453959076231 1.0529942143984659 1.1794999393534151 1.3065791680596592 0.8442821277362537 1.0 14.901666622405042 -1.5233680533532423 0.009529503586163768 1.3146777756605505e-07 2.2931739515571845 0.06552090086990947 0.1282665957511541 64234.64644760511 47.505583022929194 4961.597440817052 6575.122136704838 0.029966218829511265 1.5233680533532423 2.293173820089407 YSPTSPTYSPTT(ph)PK ddPTM_A459_Selumetinib_30min_R2 1 YSPTSPTYSPTTPK 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YSPTSPTYSPT(0.007)T(0.993)PK 206.45 1.7706e-05 6098200.0 46325.0 41833.0 44312.0 47549.0 38095.0 29884.0 38017.0 35209.0 25275.0 38265.0 True False 43750.441953668094 45041.45658570427 41461.014163257685 41072.74417339987 33309.16552637897 34000.24974005769 39784.86582925638 35311.45236083626 30330.706242505275 37160.19002559017 1.1773470997736981 1.2120889735678613 1.115737409703927 1.1052888627618789 0.8963669320162462 0.9149643668841196 1.0706313881026641 0.950249509933055 0.8162150468449756 1.0 15.181470258780124 -6.030605048762059 2.457655801765942 0.9441504839891571 1.1758831047026976 0.7063391367269782 0.0671227244247072 0.16746420520559535 2.018332287572572 0.021783498232104716 0.0324582612403217 9.319550183354227e-07 6.030605048762059 0.2317326207135405 YSQANMDAPPLS(ph)PYPFVR ddPTM_A459_Selumetinib_30min_R1 1 YSQANMDAPPLSPYPFVR 18 0 Q08999 Q08999 RBL2 Retinoblastoma-like protein 2 1 YSQANMDAPPLS(1)PYPFVR 122.22 0.00091441 9082000.0 991.85 848.49 1074.6 1648.0 1213.7 1070.0 1034.2 968.18 626.44 740.17 True False 1014.9581751958622 749.1483963477002 928.675222355277 1360.207736791353 1103.9210492961388 1059.2367714822685 956.1894613608038 942.50072130814 1063.022926632648 835.1780293663411 1.2152596686073296 0.8969924614948115 1.111948817738744 1.6286440602650405 1.3217793218694893 1.2682766239503729 1.14489297819086 1.128502772065527 1.2728099749453123 1.0 9.705939949885181 -10.827197699776704 14.324652263938486 0.999994667683391 1.2196575609693328 0.123280244005048 0.17678235848159402 1.2829926314915176e-10 0.0 0.186444729384568 0.045219488976016166 1.4886832442225483e-11 10.827197699776704 0.2196628932859418 YSQANMDAPPLS(ph)PYPFVR ddPTM_A459_Selumetinib_30min_R2 1 YSQANMDAPPLSPYPFVR 18 0 Q08999 Q08999 RBL2 Retinoblastoma-like protein 2 1 YSQANMDAPPLS(1)PYPFVR 139.78 0.00032358 4257400.0 13725.0 13462.0 16029.0 17974.0 17430.0 11813.0 15345.0 15644.0 11468.0 13368.0 True False 12962.219445528215 14494.492112847527 14997.711591055648 15525.910193120564 15240.287573822949 13440.13352226281 16058.572905540652 15689.52144999639 13761.920442692403 12982.031105764781 0.9984739167488385 1.1165041891180745 1.1552669585266813 1.1959538585781198 1.17395247705541 1.0352874224969777 1.236984627036497 1.2085567598917033 1.0600745238224938 1.0 13.66422849763032 -4.769098277563922 3.137532905646535 1.1443713436853857 0.9740661318721383 0.212209330995066 0.07497967413093003 0.516218661637065 7.452797340737794 0.018423350574656005 0.22352004067647638 1.7017733663485775e-05 4.769098277563922 -0.17030521181324743 YSQGDDDGSSSSGGSSVAGS(ph)QSTLFKDSPLR ddPTM_A459_Selumetinib_30min_R1 1 YSQGDDDGSSSSGGSSVAGSQSTLFKDSPLR 31 1 B0QY68;B0QY66;B0QY69;B0QY65;B0QY67;B0QY63;B0QY64;Q9UH99-3;Q9UH99;Q9UH99-2 B0QY68 SUN2 SUN domain-containing protein 2 1 YSQGDDDGSSS(0.001)S(0.001)GGS(0.016)S(0.016)VAGS(0.469)QS(0.337)T(0.144)LFKDS(0.015)PLR 68.32600000000001 0.00014703 3222000.0 269.19 359.91 388.96 494.11 483.27 465.81 299.97 423.13 241.08 440.62 True False 275.46160324744085 317.7715698823805 336.14136840434475 407.82296409343155 439.5583138282485 461.1243743216406 277.34302139276764 411.90721788005686 409.09515221345845 497.1778690022522 0.5540504121799377 0.639150673621277 0.6760988156591139 0.8202757795954593 0.884106757829676 0.9274837096973673 0.5578346074601951 0.8284906540725185 0.8228345984796948 1.0 8.957618268563944 -5.5477734147732924 2.1468881823200645 0.822725662865397 0.5907041218094639 0.4462530460776093 0.10962864223471108 0.3269431541617201 2.981005195886451 0.032584929266691834 0.07877206378853528 2.83286960836882e-06 5.5477734147732924 -0.2320215410559331 YSQSAPGS(ph)PVSAQPVIMAVPPRPSSLVAK ddPTM_A459_Selumetinib_30min_R1 1 YSQSAPGSPVSAQPVIMAVPPRPSSLVAK 29 1 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 Y(0.001)S(0.004)QS(0.046)APGS(0.922)PVS(0.027)AQPVIMAVPPRPSSLVAK 86.771 2.0939e-06 15150000.0 992.77 1631.4 1049.2 1485.3 1099.9 1080.4 1262.2 1039.2 450.23 1152.0 True False 1015.899609405853 1440.3949295827167 906.724402843064 1225.9202375341004 1000.4142392031174 1069.5321569247128 1166.9912377969506 1011.6370402026681 764.007426501847 1299.8704214302452 0.7815391385612578 1.1081065511113428 0.6975498387334614 0.9431095725566417 0.7696261278892425 0.822799056961315 0.8977750540033922 0.778259912314618 0.5877566055093484 1.0 10.344152098933181 -5.275079057992236 24.982153864709737 0.810792800746998 0.9448228754156067 0.13552780177032386 0.1340382462048258 1281.367081604163 2346926.3971138992 0.033241807011268394 0.06981448772665935 5.3078781201453516e-06 5.275079057992236 0.13403007466860872 YSQSAPGS(ph)PVSAQPVIMAVPPRPSSLVAK ddPTM_A459_Selumetinib_30min_R2 2 YSQSAPGSPVSAQPVIMAVPPRPSSLVAK 29 1 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 Y(0.005)S(0.048)QS(0.363)APGS(0.429)PVS(0.155)AQPVIMAVPPRPSSLVAK;YS(0.002)QS(0.021)APGS(0.783)PVS(0.194)AQPVIMAVPPRPSSLVAK 77.169 2.7308000000000007e-05 14310500.0 51271.1 40920.2 48755.2 53867.4 57011.1 47814.6 62697.0 61887.6 60608.3 54259.1 True False 48421.65751647515 44058.64776081887 45618.34351264807 46530.567193551906 49848.85593229936 54400.62713227691 65612.5347317487 62067.68266995631 72731.65353739384 52692.498800927744 0.918947831633724 0.8361464869463192 0.8657464449540373 0.8830586564008738 0.9460332507787936 1.0324169164533736 1.245196872891393 1.1779225522108565 1.3803037470698443 1.0 15.685309976839628 -6.950376406953627 1.8025969950640386 1.2198463585423462 0.8752197741124522 0.7184757011319944 0.09148958499053353 0.16929433735447041 1.1175003852932248 0.03886711972977873 0.030836382975799576 1.1210464120639602e-07 6.950376406953627 -0.344626584429894 YSQSAPGSPVS(ph)AQPVIMAVPPRPSSLVAK ddPTM_A459_Selumetinib_30min_R2 1 YSQSAPGSPVSAQPVIMAVPPRPSSLVAK 29 1 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 1 YSQSAPGS(0.239)PVS(0.761)AQPVIMAVPPRPSSLVAK 86.084 2.2728e-06 13611000.0 35415.0 25066.0 29846.0 39887.0 39910.0 30587.0 37747.0 43115.0 36599.0 32423.0 True False 33446.7760774777 26988.481600106697 27925.740853867766 34454.3217910871 34896.14900007312 34800.08160885911 39502.31029426151 43240.4575119275 43919.82266150147 31486.863744929047 1.062245396951111 0.857134639344739 0.8869013147860813 1.0942443194786575 1.1082764318085867 1.1052254010043683 1.254564780229131 1.373285629912613 1.3948617752879484 1.0 14.942462444264114 -6.596392194208233 1.0090693953338656 1.2846252985790834 0.9361913526081784 0.5074839582895769 0.12147296336823825 0.38768021708101796 0.8516330333320852 0.06375986711524652 0.06884960415823459 2.532840289285217e-07 6.596392194208233 -0.34843394597090493 YSS(ph)DDTLDR ddPTM_A459_Selumetinib_30min_R2 2 YSSDDTLDR 9 0 O95171-3;O95171-2;O95171;F2Z2X8 O95171-3 SCEL Sciellin 1 YS(0.132)S(0.867)DDT(0.001)LDR;YS(0.225)S(0.775)DDTLDR 158.47 0.00087461 16172600.0 58446.0 55023.0 72395.0 84848.0 96507.0 69389.0 45951.0 47712.0 59790.0 75574.0 True False 55197.805297875544 59243.08717316969 67737.18451771604 73291.55602903588 84382.92787647335 78946.70489937306 48087.812550179144 47850.83402085322 71749.6706721816 73391.98225516676 0.7520958502791992 0.807214703197351 0.9229507425240224 0.9986316458140929 1.1497567620274056 1.075685687639473 0.6552188818526398 0.6519899388258388 0.9776227384447088 1.0 16.163334843264842 -10.128553218612694 8.013105779084501 1.000018182159767 0.8892632121675009 0.0416011994230453 0.16128736368993205 0.0 0.0 0.17395192212162683 0.04218953815804029 7.437839137563571e-11 10.128553218612694 -0.11075496999226597 YSS(ph)LVIFPR ddPTM_A459_Selumetinib_30min_R1 1 YSSLVIFPR 9 0 P46934-3;P46934-2;P46934;H0YA37 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 YS(0.208)S(0.792)LVIFPR 131.52 0.0036016 0.0 2799.3 2676.4 3213.6 3410.0 3196.2 2797.2 2714.2 2569.3 1675.9 2467.8 True False 2864.518243510385 2363.0458437753973 2777.2107710412415 2814.5075136277387 2907.1042743349426 2769.0627076543915 2509.465708785044 2501.1538177374096 2843.8798971069155 2784.5661684076053 1.028712578645061 0.8486226222904731 0.9973585122703081 1.0107526068368688 1.0440061749358294 0.994432360441239 0.9012052711320984 0.8982202851253237 1.021300886785258 1.0 11.443236859825046 -4.924036235411983 0.0018368702685638352 1.6505803656341982 0.2844949189875597 0.00045980200270268057 0.06313653558006696 3014657.9405397205 904.8803612349371 332221.2381904223 340777.0801477427 1.191142620754368e-05 4.924036235411983 -1.3660854466466386 YSS(ph)LVIFPR ddPTM_A459_Selumetinib_30min_R2 1 YSSLVIFPR 9 0 P46934-3;P46934-2;P46934;H0YA37 P46934-3 NEDD4 E3 ubiquitin-protein ligase NEDD4 1 YS(0.37)S(0.63)LVIFPR 112.11 0.0098852 2364900.0 13142.0 11970.0 16325.0 14779.0 21291.0 12391.0 7648.1 11308.0 10026.0 15600.0 True False 12411.620251594302 12888.060510383675 15274.667273316069 12766.074704802984 18616.234236045006 14097.747775701217 8003.751804422644 11340.904407859824 12031.480149846 15149.587466332325 0.8192711702003278 0.850720228456745 1.0082563176892911 0.8426681408436805 1.2288277999263533 0.9305697470001303 0.5283148351207435 0.7485949325724727 0.794178731043611 1.0 13.886990888206105 -7.035191071439675 24.809659783660067 0.7443388669061419 0.9555136721611373 0.24203478762425734 0.1530657772501034 703.3482288913124 495857.4764107188 0.05817290976924922 0.045082725982241965 9.221656235202526e-08 7.035191071439675 0.21117480525499532 YSS(ph)PPASTTR ddPTM_A459_Selumetinib_30min_R1 2 YSSPPASTTR 10 0 Q08999;F5H837 Q08999 RBL2 Retinoblastoma-like protein 2 1 YS(0.004)S(0.995)PPAS(0.001)TTR;YS(0.077)S(0.757)PPAS(0.129)T(0.037)TR 190.57 0.0001798 33918000.0 11417.6 14100.3 12645.5 13919.900000000001 13681.6 11994.599999999999 12769.5 12157.8 6373.3 10195.3 True False 11683.607865217802 12449.43032094837 10928.310556759414 11489.050773884688 12444.101695682666 11873.945214225432 11806.286334216577 11835.335649899926 10815.02461258517 11503.96606563175 1.0156156406026557 1.0821859391728568 0.9499602566985907 0.9987034652517255 1.0817227401999718 1.0321610083412016 1.0262796558039242 1.0288048123905846 0.9401127012096462 1.0 13.489843704787612 -8.241813692812904 24.09252900509961 0.970056355959988 1.0272437927416986 0.25996544751684225 0.03837954507976651 604.1515642160823 741661.111535922 0.026257498404310596 0.009889458559944692 5.730418064100799e-09 8.241813692812904 0.05718743678171068 YSS(ph)PPASTTR ddPTM_A459_Selumetinib_30min_R2 1 YSSPPASTTR 10 0 Q08999;F5H837 Q08999 RBL2 Retinoblastoma-like protein 2 1 YS(0.029)S(0.969)PPAS(0.002)TTR 105.4 0.012536 2596900.0 35970.0 28501.0 37749.0 38180.0 43755.0 27512.0 30734.0 31804.0 26689.0 38771.0 True False 33970.93139931875 30686.935054840862 35320.27043800358 32979.81813582634 38258.10572533698 31301.52827092985 32163.19189826565 31896.544374564368 32027.545752966267 37651.5804908443 0.9022444996055193 0.8150238225007042 0.9380820134919005 0.8759212151491491 1.016108891753964 0.8313469942793348 0.8542321857136048 0.8471502114584704 0.8506295176839754 1.0 15.200422805361542 -5.262117265424338 24.999930798312835 0.8951847341110334 0.8586341655953192 0.05931300032643372 0.064551318831943 201.42054770312987 7428461.442880987 0.01670279288432933 0.03816470318372271 5.468682810736725e-06 5.262117265424338 -0.036550568515714144 YSS(ph)PTAGSAK ddPTM_A459_Selumetinib_30min_R1 4 YSSPTAGSAK 10 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 YS(0.062)S(0.933)PT(0.004)AGSAK;YS(0.081)S(0.871)PT(0.047)AGSAK;YS(0.007)S(0.971)PT(0.022)AGSAK;YS(0.006)S(0.771)PT(0.223)AGSAK 184.36 0.00017599 331056000.0 38358.1 46557.7 46961.8 50691.5 42388.2 38670.4 39956.8 37706.4 19829.0 28923.999999999996 True False 39251.76909813014 41106.702839912476 40584.64550270247 41839.18112230515 38554.19479424451 38281.41088591393 36942.826406595785 36706.30378435132 33648.36474714062 32636.677143618417 1.2026888927877635 1.2595247567337056 1.243528724572935 1.281968165392295 1.1813149550913509 1.1729567540670804 1.1319420247357923 1.1246948830858123 1.0309984867353454 1.0 14.994206558413532 -7.679220926887186 0.6389658665613172 0.9978333000979973 1.2502807552061495 0.9060421672062143 0.027139251548597046 0.20647914959415445 0.1695081927560626 0.025842404246673622 0.014319921240189949 2.093047445562062e-08 7.679220926887186 0.25244745510815214 YSS(ph)PTAGSAK ddPTM_A459_Selumetinib_30min_R2 3 YSSPTAGSAK 10 0 P28749;P28749-2 P28749 RBL1 Retinoblastoma-like protein 1 1 YS(0.058)S(0.75)PT(0.191)AGSAK;Y(0.001)S(0.084)S(0.906)PT(0.008)AGSAK;Y(0.001)S(0.202)S(0.791)PT(0.006)AGSAK 155.26 0.00052832 231947000.0 401790.0 370040.0 446630.0 441550.0 478150.0 340714.0 361230.0 369100.0 301694.0 395510.0 True False 379460.1202928076 398420.8781338663 417894.3120539753 381410.1282837647 418080.52228476474 387644.26080625143 378027.91076366586 370174.0198922055 362041.2300346745 384090.59864160855 0.9879443069807557 1.0373096335680665 1.0880097391915304 0.9930212549660843 1.08849454728485 1.0092521456583705 0.9842154744235234 0.9637674579939706 0.9425933134398113 1.0 18.551087125993575 -7.200472716403656 2.714385499924733 0.9673263971008366 1.0394431372756316 0.45109260008211627 0.034121708310969674 0.24343852112977296 3.5284141225712937 0.014716140406925378 0.010378427306522381 6.302709401337512e-08 7.200472716403656 0.07211674017479508 YSS(ph)QDADEQDWEFQKR ddPTM_A459_Selumetinib_30min_R2 1 YSSQDADEQDWEFQKR 16 1 Q9C0C2;Q9C0C2-2;A0A2R8Y5C4 Q9C0C2 TNKS1BP1 182 kDa tankyrase-1-binding protein 1 YS(0.132)S(0.868)QDADEQDWEFQKR 134.33 0.00023645 7309700.0 13082.0 15155.0 19434.0 15974.0 13004.0 9978.5 12721.0 14182.0 9300.6 14471.0 True False 12354.954811395268 16317.339768994536 18183.63759813932 13798.313643313002 11370.32126276498 11352.947799195757 13312.551706183298 14223.267272043517 11160.97988047653 14053.184629826617 0.8791569410660833 1.1611133133739988 1.2939157975300624 0.9818638270806835 0.8090921426188693 0.8078558773859805 0.9472978585884801 1.0121027828707176 0.7941957765778126 1.0 13.778609480033966 -5.992091391649582 24.880025895384552 0.8940838911006139 1.1199543116162054 0.39620484458297833 0.11939637600365018 172.99609494074173 544228.7537759405 0.03415976920797898 0.05056346364545443 1.01837706123925e-06 5.992091391649582 0.22587042051559147 YSS(ph)SQPEPR ddPTM_A459_Selumetinib_30min_R2 3 YSSSQPEPR 9 0 E7EPP6;O14757-2;O14757-3;O14757 E7EPP6 CHEK1 Serine/threonine-protein kinase Chk1 1 YS(0.187)S(0.406)S(0.406)QPEPR;YS(0.022)S(0.489)S(0.489)QPEPR;YS(0.18)S(0.41)S(0.41)QPEPR 91.701 0.02687 6169200.0 48076.0 52996.0 54436.0 58597.0 64738.0 49821.0 56445.0 59179.0 47062.0 56992.0 True False 45404.12838347645 57060.62279100196 50933.647025435435 50615.98751453687 56605.0336749369 56683.39051999117 59069.80434364563 59351.201092389136 56475.715022147684 55346.49287700076 0.8203614361686887 1.0309708858664377 0.920268735701606 0.9145292661456125 1.0227393052841316 1.024155056147125 1.0672727624299405 1.0723570366832138 1.0204027768779578 1.0 15.756204280670751 -6.349018770523433 4.081711068340156 1.0414442611092174 0.9291683965578197 0.5316771896614048 0.05167833205419247 0.187418585171784 5.717967810524879 0.015924878608512882 0.018354236958906582 4.4769395409983496e-07 6.349018770523433 -0.11227586455139771 YSS(ph)YQGSR ddPTM_A459_Selumetinib_30min_R1 1 YSSYQGSR 8 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 YS(0.049)S(0.951)YQGSR 94.409 0.023658 0.0 1988.2 2379.1 2292.6 2381.1 2221.8 2019.8 1756.1 2068.8 1320.8 1765.2 True False 2034.5211916362468 2100.5538659864164 1981.2775123503714 1965.2855837827008 2020.8385822906503 1999.4826458316675 1623.6359631557796 2013.9287035905302 2241.3011325847688 1991.7806145040527 1.0214584763105732 1.0546110604201497 0.9947267775993007 0.9866978167533029 1.0145889399540284 1.003866907465375 0.8151680718913212 1.011119743271521 1.1252751012153244 1.0 10.959843034579492 -5.352797231750607 5.760302346895126 0.988397848093405 1.037743970307171 0.05372028074903079 0.07133789075984494 0.6407307401642717 31.90949176538575 0.01971419945447616 0.042044110197878674 4.43815809238692e-06 5.352797231750607 0.049346122213765886 YSS(ph)YQGSR ddPTM_A459_Selumetinib_30min_R2 3 YSSYQGSR 8 0 Q8TEW0-11;Q8TEW0-2;Q8TEW0;Q5VWV2;Q8TEW0-6;Q8TEW0-4;Q8TEW0-7;Q8TEW0-3;Q8TEW0-5 Q8TEW0-11 PARD3 Partitioning defective 3 homolog 1 YS(0.047)S(0.953)YQGSR;Y(0.001)S(0.159)S(0.84)YQGSR;YS(0.132)S(0.868)YQGSR 131.12 0.0036497 21812600.0 77918.0 75289.0 95135.0 99640.0 101438.0 87179.0 74748.0 76084.0 73548.0 96154.0 True False 73587.62949046762 81063.42420770899 89014.11767515633 86068.86011141278 88694.45157277414 99187.11591783194 78223.93011035206 76305.39184361575 88259.65510282008 93377.78418190498 0.788063564960108 0.8681232363555881 0.953268686497765 0.9217273772929327 0.9498453229516836 1.0622132104206934 0.8377145677173877 0.8171685857844808 0.9451890069578593 1.0 16.510791733949794 -4.917319315318383 2.7276057991179163 0.9302144151304237 0.7798555520647018 0.32135407881563416 0.06711914910082813 0.4549136312110374 5.64414124192925 0.018606513337302247 0.13602184479508608 1.2097083675755746e-05 4.917319315318383 -0.15035886306572188 YSSEVATES(ph)PLDFTK ddPTM_A459_Selumetinib_30min_R1 1 YSSEVATESPLDFTK 15 0 Q8WTT2 Q8WTT2 NOC3L Nucleolar complex protein 3 homolog 1 YS(0.001)S(0.002)EVAT(0.303)ES(0.613)PLDFT(0.082)K 80.738 0.028612 4252700.0 1626.4 2589.1 2405.9 2423.8 2117.6 2178.9 2054.7 2039.8 1096.4 2165.7 True False 1664.291955576498 2285.9669683600655 2079.1919946627245 2000.5288303609707 1926.063453892645 2156.982244282909 1899.71232475154 1985.697877795807 1860.51072211231 2443.688690704413 0.6810572729281454 0.9354575224969089 0.8508415996570252 0.8186512619102485 0.7881787321025091 0.8826747255032479 0.777395390819578 0.8125821776518569 0.7613534118275936 1.0 11.25484479200228 -10.543870189081165 4.623394378726068 1.0000049587024662 0.8173634616085346 0.4202244035839122 0.06597179027371132 88868155.9826853 53359006.22404172 5610.331928189803 0.015699155032224955 2.858444806814037e-11 10.543870189081165 -0.18264149709393163 YSSSFCTHDR ddPTM_A459_Selumetinib_30min_R2 1 YSSSFCTHDR 10 0 K7ERV3;P04183;K7ENW5;K7ES52;K7ERJ1 K7ERV3 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 135.8 0.0050477 0.0 11793.0 11933.0 16695.0 20858.0 28334.0 18747.0 11462.0 15994.0 14694.0 22483.0 False True 11137.592271119425 12848.22272935743 15620.861876141615 18017.10441794305 24774.42961082614 21329.229081677877 11995.005711522124 16040.539892050772 17633.2105846636 21833.85737215064 0.510106486512345 0.5884540926673589 0.7154421506877764 0.8251910833183372 1.1346794654079877 0.976887808605161 0.549376388563475 0.7346635831976572 0.8076085816679824 1.0 14.414279412308767 -5.4117366004330325 2.120022722319524 0.852461053919551 0.5309978436842413 0.4098416882635161 0.1506430763484652 0.38815632572493974 3.3170657666024908 0.048068977663882774 0.14076978479090535 3.874925878901312e-06 5.4117366004330325 -0.32146321023530966 YSTPHAFTFNTSS(ph)PSSEGSLSQR ddPTM_A459_Selumetinib_30min_R2 1 YSTPHAFTFNTSSPSSEGSLSQR 23 0 H7C155;P04049;P04049-2 H7C155 RAF1 RAF proto-oncogene serine/threonine-protein kinase 1 YSTPHAFTFNTS(0.007)S(0.388)PS(0.388)S(0.215)EGS(0.004)LSQR 167.95 2.0284e-12 4914200.0 15830.0 15834.0 19521.0 22159.0 22428.0 18472.0 14140.0 18237.0 18793.0 21879.0 True False 14950.231972510865 17048.416885665425 18265.040112857776 19140.905973592886 19610.394131136043 21016.35032787934 14797.53801787845 18290.066650702134 22552.125120292818 21247.29642153111 0.7036298489892074 0.8023805263237764 0.8596406691229082 0.9008631307179534 0.9229595023329038 0.989130565646096 0.696443336804171 0.860818538407915 1.0614115166878102 1.0 14.374991659040175 -4.825378252199069 1.153973855714724 0.9077970923845251 0.6165054744154663 0.35284167709886205 0.09281211559004258 1.888005892905964 2.218896217002912 0.029806310004306703 0.6571496071367903 1.4949330652001886e-05 4.825378252199069 -0.2912916179690588 YSVGSLS(ph)PVSASVLK ddPTM_A459_Selumetinib_30min_R1 1 YSVGSLSPVSASVLK 15 0 Q9UBU7 Q9UBU7 DBF4 Protein DBF4 homolog A 1 YS(0.01)VGS(0.058)LS(0.906)PVS(0.025)AS(0.001)VLK 119.65 0.0018834 76405000.0 1222.7 1190.7 1560.9 1984.1 1617.0 1171.7 1230.0 1283.0 800.7 1209.4 True False 1251.1865310399567 1051.2922904585873 1348.9383534099695 1637.6141811697341 1470.7426355045372 1159.9137618184795 1137.2201097213183 1248.970672228659 1358.7294191858136 1364.6382705535923 0.916863140979029 0.7703816558157276 0.9884951803841366 1.2000353621223034 1.0777527402246323 0.8499789188441401 0.8333491257430312 0.9152393708861686 0.9956700237013127 1.0 10.414302866255058 -5.280126090304993 24.139363789113695 0.9806399290217195 0.8436224019493488 0.21600690414386103 0.10583015059061465 799.8793804846907 1033278.3226903402 0.03156598038076923 0.06592378969950104 5.246551130976253e-06 5.280126090304993 -0.1370175270723707 YSVGSLS(ph)PVSASVLK ddPTM_A459_Selumetinib_30min_R2 2 YSVGSLSPVSASVLK 15 0 Q9UBU7 Q9UBU7 DBF4 Protein DBF4 homolog A 1 YSVGS(0.078)LS(0.916)PVS(0.006)ASVLK;YSVGS(0.005)LS(0.969)PVS(0.026)ASVLK 181.58 2.0257e-05 37460000.0 114211.0 103540.0 123982.0 134686.0 129951.0 104358.0 110554.0 124590.0 95530.0 115596.0 True False 107863.60984285778 111481.18506642657 116005.13310139491 116341.53445369088 113625.39360331984 118732.36723239657 115694.98005859517 124952.53627301508 114638.66933121762 112258.44312552248 0.9608507550942018 0.9930761728253543 1.0333755740018864 1.036372242608094 1.012176816636134 1.0576698190944553 1.0306127257548914 1.1130791840155723 1.021203092964987 1.0 16.776464430737214 -3.7219796967717924 0.6243141339403364 1.0476092520590796 0.6790888949884226 0.416480489059496 0.02957255631367233 10.116229358096959 1.0973390743087486 0.012865706151821657 3.604644796993888 0.00018967945941161262 3.7219796967717924 -0.368520357070657 YSVLNNDDYFADVS(ph)PLR ddPTM_A459_Selumetinib_30min_R1 3 YSVLNNDDYFADVSPLR 17 0 Q1ED39;H3BMC9 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 YSVLNNDDYFADVS(1)PLR;YSVLNNDDYFADVS(1)PLR;YSVLNNDDYFADVS(1)PLR 292.19 6.717399999999998e-76 38960000.0 3371.25 4330.96 3429.81 3110.99 3265.26 2918.94 3606.89 3145.74 1899.3500000000001 2730.14 True False 3449.793565689417 3823.8891897913186 2964.0606405977605 2567.713997014887 2969.9178095284747 2889.5781137854697 3334.8193833762007 3062.3047563964014 3223.0582269646266 3080.580062815599 1.1198519419541926 1.2412886897334352 0.9621761422063669 0.8335163977747876 0.9640774623510415 0.937998057140071 1.0825296909596407 0.9940675762205335 1.0462504337637 1.0 11.588986315762185 -5.269847981637248 24.893395658586606 0.9740727241824036 1.1805703181523681 0.5849184763382367 0.06834976129506173 365.8885521878831 1083203.4314587929 0.019020077787139426 0.04064323076698749 5.372198093147144e-06 5.269847981637248 0.20649759396996448 YSVLNNDDYFADVS(ph)PLR ddPTM_A459_Selumetinib_30min_R2 7 YSVLNNDDYFADVSPLR 17 0 Q1ED39;H3BMC9 Q1ED39 KNOP1 Lysine-rich nucleolar protein 1 1 YSVLNNDDYFADVS(1)PLR;YSVLNNDDYFADVS(1)PLR;YSVLNNDDYFADVS(1)PLR;YSVLNNDDYFADVS(1)PLR;YSVLNNDDY(0.008)FADVS(0.992)PLR;YSVLNNDDYFADVS(1)PLR;YSVLNNDDYFADVS(1)PLR 195.48 8.859200000000001e-21 7154600.0 60826.0 52056.49999999999 65704.3 67933.20000000001 72662.8 59479.2 60543.600000000006 53335.869999999995 48780.5 60408.4 True False 57445.53442577039 56049.066161970535 61476.95687143288 58680.58096869357 63534.249450325944 67671.9199015808 63358.99736486746 53491.06855147137 58537.96304104955 58664.25253212756 0.9792255410449534 0.9554211251779811 1.047945796935961 1.0002783370768606 1.0830147271633832 1.153546103131889 1.080027352776187 0.9118170988742575 0.9978472496345394 1.0 15.840194034426135 -5.262197792317937 24.973632353207126 1.03757548725613 0.9673233293372341 0.1576557094773522 0.061565768310697204 123.8646516721549 4078913.4047866454 0.017836261270374916 0.0409596371686093 5.467668901436864e-06 5.262197792317937 -0.07025215791889594 YSVQTADHR ddPTM_A459_Selumetinib_30min_R1 3 YSVQTADHR 9 0 Q16658 Q16658 FSCN1 Fascin 0 ;; 150.27 0.0018798 18260400.0 15031.800000000001 14714.699999999999 17248.1 16571.5 18301.5 13528.1 15589.899999999998 15550.2 7988.299999999999 12370.8 False True 15382.011693208802 12991.896083321566 14905.902757031507 13677.598610581254 16646.13255639226 13392.019596532025 14413.941291499503 15137.758181831721 13555.561657652099 13958.71268179625 1.1019649192485133 0.9307374096369557 1.0678565492984535 0.979861031771103 1.192526340777879 0.9594021957337615 1.0326125066172414 1.084466635778891 0.9711183234919717 1.0 13.768878277169733 -8.282741512662477 24.68453257315478 0.9855591502280144 1.040375962745774 0.09219244808664973 0.0723594337830336 2055.019615550395 2381292.039373841 0.06554578873856827 0.016990147961335883 5.215050128458967e-09 8.282741512662477 0.054816812517759606 YSVQTADHR ddPTM_A459_Selumetinib_30min_R2 4 YSVQTADHR 9 0 Q16658 Q16658 FSCN1 Fascin 0 ;;; 182.46 0.0022042 28735700.0 253818.0 208868.0 284088.0 301054.0 308975.0 229748.0 231295.0 232885.0 224165.0 245342.0 False True 239711.81167395844 224887.50398352693 265810.0873716267 260049.92585288337 270158.79822845367 261393.70155530615 242050.67580234795 233562.65679381296 269004.26369341987 238258.33898493001 1.006100406370752 0.9438809358851075 1.1156381283613304 1.0914620111967275 1.1338902108502544 1.0971020056168506 1.015916911171188 0.9802916354948061 1.1290444852401769 1.0 17.86216718343737 -5.256813643474485 24.967033719677158 1.071739248053735 0.9749906681180972 0.33676989892678477 0.05354153089221577 442.3561208930916 2387556.610944859 0.014314759145883775 0.03540936370593231 5.535876036711871e-06 5.256813643474485 -0.0967485799356379 YT(ph)LHYKTDAPLNIRSIFY(ph)VPDMK ddPTM_A459_Selumetinib_30min_R2 1 YTLHYKTDAPLNIRSIFYVPDMK 23 2 I3L239;I3L0K7;Q12931-2;Q12931 I3L239 TRAP1 Heat shock protein 75 kDa, mitochondrial 2 Y(0.305)T(0.336)LHY(0.305)KT(0.055)DAPLNIRS(0.152)IFY(0.848)VPDMK 48.65600000000001 0.045842 0.0 10961.0 9822.1 11855.0 13631.0 15026.0 13997.0 12368.0 14615.0 9772.0 12993.0 True False 10351.831500359536 10575.423486970716 11092.262206748059 11774.43428521344 13138.299545855638 15924.959697884744 12943.136506727073 14657.527230356502 11726.673052493035 12617.85833013179 0.8204111370975754 0.8381314174146587 0.8790923084196811 0.9331563231373242 1.0412463987237057 1.2620968853212993 1.025779190737822 1.161649373995104 0.9293711139939985 1.0 13.623179437357857 -6.08924702549321 2.152098519202736 1.0874197174960598 0.8429591207672508 0.5807369833040167 0.08651657916053195 0.21284380613088966 1.9484652278371584 0.027577100732606843 0.040280480686486764 8.142410142561558e-07 6.08924702549321 -0.24446059672880904 YTEDMTPTEQT(ph)PR ddPTM_A459_Selumetinib_30min_R1 1 YTEDMTPTEQTPR 13 0 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 YTEDMT(0.003)PT(0.007)EQT(0.991)PR 101.61 0.023332 2033300.0 1233.1 1502.7 935.79 1314.5 1447.3 1112.9 1141.2 1088.3 545.56 883.92 True False 1261.8288308050792 1326.7631854137226 808.7148579265262 1084.9472512210157 1316.391970541568 1101.7052364323517 1055.1183652146094 1059.4347487033901 925.7754738741265 997.3797421099151 1.265143833917995 1.3302487802760166 0.8108394664360474 1.0877975613639947 1.3198503187530117 1.104599572176732 1.057890310647929 1.0622180338876748 0.9282076172067494 1.0 9.961999090337038 -5.203686915119374 24.999943436720873 1.0623767829451727 1.2976967623619338 0.38815879705993517 0.12490975023493435 306.76801595688016 132792.62533965718 0.0332078254399512 0.08785956208203446 6.256235451237905e-06 5.203686915119374 0.23531997941676108 YTEDMTPTEQT(ph)PR ddPTM_A459_Selumetinib_30min_R2 1 YTEDMTPTEQTPR 13 0 A0A1X7SBR1;Q7Z3G6 A0A1X7SBR1 PRICKLE2 Prickle-like protein 2 1 YTEDMTPTEQT(0.999)PR 113.43 0.010688 5028500.0 17464.0 14001.0 21699.0 20772.0 18965.0 15777.0 15739.0 16288.0 13496.0 14368.0 True False 16493.420793931127 15074.831679689376 20302.909964084873 17942.817766301327 16582.447150748845 17950.13854065355 16470.89468623685 16335.395383376444 16195.577109746833 13953.158507452747 1.1820564343995348 1.0803884777512929 1.4550762791980438 1.2859323397435498 1.1884368074720664 1.2864570076420985 1.1804420251829946 1.1707310122400805 1.1607104657412408 1.0 13.76830411431028 -8.661485120740945 0.7088928843279926 1.0003200562463466 1.2478625593459114 0.3823873837028916 0.09213924811439654 0.9959623388082102 1.0873674577363148 0.09658668271483999 0.036735736981774146 2.1802930944049895e-09 8.661485120740945 0.24754250309956483 YTGEDFDEDLR ddPTM_A459_Selumetinib_30min_R1 1 YTGEDFDEDLR 11 0 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 192.64 5.2737e-18 0.0 1140.8 1426.9 1418.0 1303.1 1343.7 1330.6 1397.3 1387.3 595.51 1030.9 False True 1167.3784203896141 1259.8378846521873 1225.443388516456 1075.5380472165125 1222.1625722495035 1317.2153720881363 1291.9005360273165 1350.5042974145128 1010.5369756704691 1163.2260568163542 1.0035696961471312 1.0830550753825539 1.0534868793004732 0.9246165359811179 1.0506664333108675 1.132381246421901 1.110618635523978 1.16099900745924 0.868736536418569 1.0 10.183915776448577 -4.725766099456659 22.4883188586555 1.0495765432106317 1.0035684585199667 0.012628209373025112 0.08655111746778307 7937.2057138913615 5002544.426742781 0.021639129367347975 3.462321369035207 1.880329244167439e-05 4.725766099456659 -0.046008084690664974 YTGEDFDEDLR ddPTM_A459_Selumetinib_30min_R2 1 YTGEDFDEDLR 11 0 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 131.52 0.030302 4637000.0 6407.1 4407.5 7437.4 9428.6 10002.0 7083.1 6828.7 9303.3 4971.6 7800.0 False True 6051.019031653464 4745.541077653802 6958.885781228844 8144.408414757784 8745.459340985499 8058.732731020039 7146.24808081235 9330.37106275577 5966.0589181103505 7574.793733166162 0.7988361458819841 0.6264911289762909 0.9186898054740988 1.0751987052924714 1.1545475228841662 1.0638880760191467 0.943424775980707 1.2317656944112985 0.7876199838931611 1.0 12.886990888206105 -5.477537488633342 3.8833193806598527 1.0469786285952978 0.7157631062956021 0.5334146420926816 0.1195406380112518 0.15200503755521275 4.740905309331968 0.03062047977317832 0.06504678446435629 3.3301401504239157e-06 5.477537488633342 -0.33121552229969564 YTGEEDGAGGHS(ph)PAPPQTEECLR ddPTM_A459_Selumetinib_30min_R1 3 YTGEEDGAGGHSPAPPQTEECLR 23 0 J3KS37;O94762-4;O94762;J3KSV9 J3KS37 RECQL5 ATP-dependent DNA helicase Q5 1 YTGEEDGAGGHS(1)PAPPQTEECLR;YTGEEDGAGGHS(1)PAPPQTEECLR;YTGEEDGAGGHS(1)PAPPQTEECLR 117.0 7.1279999999999985e-06 86597000.0 4096.02 5454.82 4383.77 4611.72 4790.58 4122.1 5419.6 4769.43 2682.5 4583.110000000001 True False 4191.449296532493 4816.167138522978 3788.478112324954 3806.369674705957 4357.272884845594 4080.635416567343 5010.795208655009 4642.929223107981 4552.006577951724 5171.396811771854 0.8105062228045102 0.9313087573476759 0.7325831395690023 0.7360428551994633 0.8425717544874842 0.7890779928700176 0.9689442506613956 0.8978095071991185 0.8802276722586462 1.0 12.336338294648955 -7.254978975077276 24.95220371118515 0.9282294842828659 0.807671754614051 0.51565010566315 0.06137192520140198 465.6392248983429 1798456.3410761147 0.0247213053309777 0.018672809248707456 5.5593117017732874e-08 7.254978975077276 -0.12055772966881484 YTGEEDGAGGHS(ph)PAPPQTEECLR ddPTM_A459_Selumetinib_30min_R2 1 YTGEEDGAGGHSPAPPQTEECLR 23 0 J3KS37;O94762-4;O94762;J3KSV9 J3KS37 RECQL5 ATP-dependent DNA helicase Q5 1 YT(0.001)GEEDGAGGHS(0.998)PAPPQT(0.001)EECLR 62.107 0.0053497 29580000.0 9205.9 9316.3 16072.0 20810.0 20477.0 13925.0 16983.0 14696.0 8465.1 15086.0 True False 8694.272932137572 10030.830253374052 15037.945017870494 17975.642100747675 17904.49619329735 15843.042351435675 17772.743151176084 14738.762926946238 10158.356534656035 14650.427981864708 0.5934483922858725 0.6846783087696068 1.0264509020818695 1.2269704422969172 1.222114208230691 1.0814047460625222 1.2131210892389213 1.006029512939204 0.6933829200915316 1.0 13.838655190155675 -5.244851133708504 3.51193877484031 1.080650995803271 0.6149805393157882 0.5610168910435522 0.1490371327105104 0.1692884291315452 4.4762364096605225 0.04179329230203359 0.11832842300000028 5.690479541405182e-06 5.244851133708504 -0.46567045648748284 YTIS(ph)QEAYDQR ddPTM_A459_Selumetinib_30min_R2 2 YTISQEAYDQR 11 0 K7EK42;A0A494C0X0;Q99426;K7EP07;Q99426-2 K7EK42 TBCB Tubulin-folding cofactor B 1 YT(0.01)IS(0.989)QEAYDQR;YTIS(0.995)QEAY(0.004)DQR 141.34 0.0010117 17298700.0 101167.0 134450.0 130844.0 129020.0 90499.0 56142.0 63335.0 91305.0 59298.0 81325.0 True False 95544.54314358858 144761.88267511153 122425.63949217592 111447.2534280858 79129.70654867498 63875.05089366615 66280.20299592163 91570.68243364352 71159.2569245529 78976.935942274 1.2097777914988272 1.8329640286490885 1.5501442038933944 1.411136708437829 1.001934369883793 0.8087810717340801 0.8392349260595183 1.159461067223152 0.901013138526478 1.0 16.269143776384986 -6.196953387403358 2.8838947986914016 0.9400516680419546 1.5544254031474372 0.7255310549142364 0.16676376227052822 0.13596715621969385 2.2295694583626617 0.052397853549892265 0.06866435538370988 6.353991252435591e-07 6.196953387403358 0.6143737351054825 YTISQEAYDQR ddPTM_A459_Selumetinib_30min_R2 1 YTISQEAYDQR 11 0 K7EK42;A0A494C0X0;Q99426;K7EP07;Q99426-2 K7EK42 TBCB Tubulin-folding cofactor B 0 135.8 0.020338 6925900.0 27491.0 28004.0 25931.0 33136.0 32626.0 23736.0 26471.0 25889.0 24713.0 24436.0 False True 25963.16027519243 30151.81675294774 24262.62769153807 28622.819637211687 28527.23019985929 27005.418546045017 27701.95395129139 25964.33270384534 29656.290538913265 23730.469187647246 1.094085416933408 1.2705950529053631 1.0224251151413322 1.2061632414799082 1.20213511053161 1.1380060938745589 1.1673580379823032 1.0941348229794343 1.2497136194151048 1.0 14.534453004649379 -11.024713222115611 4.3181764619168765 0.9988714330780218 1.159843147312608 0.30699266182416585 0.07234331805159822 0.000728556122314491 8.404966035501357e-05 0.06492609056874318 0.015638461548675386 9.446844743267528e-12 11.024713222115611 0.16097171423458623 YTPPT(ph)QPPISPPYQEACTLKR ddPTM_A459_Selumetinib_30min_R1 1 YTPPTQPPISPPYQEACTLKR 21 1 B7Z4K4;Q9UET6-2;Q9UET6 B7Z4K4 FTSJ1 Putative tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase 1 Y(0.002)T(0.097)PPT(0.819)QPPIS(0.082)PPYQEACTLKR 119.68 0.00064486 0.0 2158.6 2208.2 3335.5 3357.3 3092.8 2236.5 2536.3 2640.8 1549.3 2134.0 True False 2208.891180095567 1949.6629174356704 2882.5574205900143 2771.0105793262187 2813.0567860781894 2214.0028405795265 2344.9848490131544 2570.757405472678 2629.0489436050734 2407.9196869202638 0.9173442088181709 0.8096876851940584 1.1971152676926753 1.1507902835706074 1.1682519152771649 0.9194670622138741 0.9738633982483016 1.0676258927724802 1.091834149571506 1.0 11.233571558315294 -5.248736075938296 24.883220701825202 1.0709586611628734 0.8635159293309853 0.47765800576552553 0.0868382174306482 668.6476473178393 1309740.057342566 0.024037675760275445 0.062678700374088 5.639802868179601e-06 5.248736075938296 -0.2074427318318881 YTPPTQPPIS(ph)PPYQEACTLK ddPTM_A459_Selumetinib_30min_R2 2 YTPPTQPPISPPYQEACTLK 20 0 B7Z4K4;Q9UET6-2;Q9UET6 B7Z4K4 FTSJ1 Putative tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase 1 YTPPT(0.002)QPPIS(0.975)PPY(0.022)QEACTLK;YTPPTQPPIS(0.99)PPY(0.009)QEACTLK 76.161 0.0038313 6155500.0 26753.0 24271.0 32749.0 35533.0 36213.0 24256.0 27846.0 38273.0 34625.0 40920.0 True False 25266.17536074435 26132.507656434605 30641.964994415186 30693.34410215604 31663.599191672456 27597.043825955032 29140.894175802212 38384.36809356378 41550.96750333314 39738.533277071736 0.635810465992271 0.657611278056719 0.7710894808514468 0.7723824099936126 0.7967983863647443 0.6944655866772497 0.7333157963486254 0.965923121166395 1.0456089864621938 1.0 15.278251004201824 -7.807093941593782 3.9102997682491107 1.017487396355365 0.7245938612244925 0.8733641353216499 0.04927683282993168 0.0801252471215434 2.5278233896514815 0.03170488210786512 0.014813421829473683 1.5592151948260253e-08 7.807093941593782 -0.29289353513087246 YTPPTQPPIS(ph)PPYQEACTLKR ddPTM_A459_Selumetinib_30min_R1 1 YTPPTQPPISPPYQEACTLKR 21 1 B7Z4K4;Q9UET6-2;Q9UET6 B7Z4K4 FTSJ1 Putative tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase 1 YTPPT(0.002)QPPIS(0.997)PPYQEACTLKR 113.89 4.2753e-05 25176000.0 2023.1 2246.7 3548.1 3595.2 2996.6 2429.3 2511.0 2628.5 1420.2 1701.8 True False 2070.2342937326684 1983.6553195375075 3066.287508318222 2967.3658102623003 2725.5580590926998 2404.8634476279194 2321.5932483823008 2558.7836414287076 2409.9756726960077 1920.2426069357564 1.0781108002994801 1.0330232817315426 1.5968229729113639 1.5453077645212236 1.4193821391360713 1.2523747983414975 1.2090103823323675 1.3325314375311714 1.2550370791645682 1.0 10.907072879833445 -6.926773113225377 7.768169661386124 1.227380673211555 1.3438375312805562 0.09904684715373746 0.18476716381252245 0.7457933525254699 68.40376063598211 0.07187725822642209 0.06334929616127041 1.18365976898854e-07 6.926773113225377 0.11645685806900108 YTPPTQPPIS(ph)PPYQEACTLKR ddPTM_A459_Selumetinib_30min_R2 1 YTPPTQPPISPPYQEACTLKR 21 1 B7Z4K4;Q9UET6-2;Q9UET6 B7Z4K4 FTSJ1 Putative tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase 1 YTPPTQPPIS(0.979)PPY(0.021)QEACTLKR 117.02 3.9096e-05 6661300.0 72007.0 87626.0 72235.0 98136.0 87427.0 56594.0 46473.0 51121.0 49174.0 86416.0 True False 68005.13920685973 94346.63243800154 67587.4787435213 84769.70750595727 76443.63865270343 64389.3097908187 48634.08658450252 51269.75364646286 59010.174036358214 83920.94554426774 0.8103476285427155 1.1242322381631689 0.8053707963510652 1.0101138274382504 0.9109005881300506 0.7672614908378715 0.5795226241683413 0.6109291704705401 0.7031638365565214 1.0 16.356743312521125 -6.829027376582887 3.316987932840186 0.6893213731516428 0.9428695025229674 0.3367267592869312 0.13776828462789065 0.22806151667058272 5.052385276226566 0.048017262655190227 0.04301385907492717 1.4824246347298417e-07 6.829027376582887 0.25354812937132465 YTPSGQAGAAASESLFVS(ph)NHAY ddPTM_A459_Selumetinib_30min_R1 1 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;P04075-2;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 YTPSGQAGAAASESLFVS(0.719)NHAY(0.281) 202.25 1.4513999999999995e-22 6434100.0 633.99 1012.2 772.64 1011.5 1107.0 895.32 677.11 802.09 450.45 471.32 True False 648.7607334702069 893.6911534409861 667.7197318077255 834.8605132065863 1006.8720454567238 886.3138936855186 626.0350475556116 780.8159676444936 764.3807504336828 531.8185130455761 1.2198912176917938 1.6804438572908387 1.255540594071991 1.5698222095082275 1.8932624960546198 1.6665720954500933 1.1771591853214807 1.468200050376168 1.4372962423896976 1.0 9.054790189260947 -9.172822775572014 0.6659865879019102 0.9889749991702943 1.524202568930296 0.3241605731747146 0.21395137124948493 2.841025907049546 1.8804193022392148 0.30773180353275353 0.08579365168794803 6.717029017148985e-10 9.172822775572014 0.5352275697600017 YTPSGQAGAAASESLFVS(ph)NHAY ddPTM_A459_Selumetinib_30min_R2 2 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;P04075-2;J3KPS3;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 YTPSGQAGAAASESLFVS(0.992)NHAY(0.008);YTPSGQAGAAASESLFVS(1)NHAY 157.68 5.3790000000000006e-09 7079000.0 18210.9 13349.8 25276.0 24866.0 23682.0 12420.2 15779.6 14903.2 14224.3 19387.2 True False 17198.81108200872 14373.686733627394 23649.769678427998 21479.207903757404 20706.85544023381 14130.96981065 16513.382666684225 14946.565844642424 17069.557460149063 18827.44116200501 0.9134970033377149 0.7634434552176119 1.2561329749979386 1.140845838737971 1.099823139111521 0.7505517977221041 0.8770911843298864 0.7938713347199596 0.9066318313397006 1.0 14.200549316106013 -6.7535920063370565 24.99983530871294 0.8534625552765307 1.037869425668449 0.26931205439760764 0.13851346630940015 246.32503121929759 784730.950801247 0.04929963737882393 0.04843922195285442 1.763632095168792e-07 6.7535920063370565 0.1844068703919184 YTPTSPSYSPSS(ph)PEYTPTSPK ddPTM_A459_Selumetinib_30min_R2 1 YTPTSPSYSPSSPEYTPTSPK 21 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 YTPTSPSYS(0.001)PS(0.274)S(0.724)PEYTPTSPK 97.623 0.00023371 3628900.0 35486.0 29550.0 32658.0 38047.0 39611.0 31999.0 28259.0 37045.0 28000.0 37929.0 True False 33513.83018171321 31816.38998177422 30556.819835341885 32864.93296526414 34634.712053167015 36406.57179199928 29573.09949414618 37152.79481687011 33600.782385366845 36833.891218623 0.9098639615020856 0.8637803101749956 0.829584353550258 0.8922471093319573 0.9402946826225057 0.9883987433180107 0.8028774184790499 1.0086578851078833 0.9122246190589411 1.0 15.16874619452455 -7.8108344024605 0.18777869656100038 1.0310117760003101 0.8307496719993195 0.26285227747756723 0.057637120727440094 4.320765910279372 0.8263592832405353 0.330968882005477 0.367402392664515 1.5458437611525652e-08 7.8108344024605 -0.20026210400099065 YTQS(ph)NSVCYAK ddPTM_A459_Selumetinib_30min_R2 1 YTQSNSVCYAK 11 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 1 Y(0.001)T(0.001)QS(0.988)NS(0.01)VCYAK 142.39 0.0036578 0.0 12288.0 8900.7 9964.0 10482.0 9885.8 10210.0 9247.8 9479.3 9012.2 9899.6 True False 11605.08215276143 9583.35506973868 9322.92708798293 9054.333517541434 8643.857423826676 11616.334822847983 9677.84102416806 9506.883193617407 10814.89182190726 9613.772825750231 1.20713089055709 0.9968360230096057 0.9697469720744514 0.9418085575404535 0.8991118867167671 1.2083013644480909 1.0066642097310874 0.9888816145263466 1.1249373183584974 1.0 13.230886997537123 -6.726795563346122 24.999930451968424 1.0613694076629938 0.9973498265582954 0.09179634824949734 0.09754441407604975 485.00744842455356 349993.28278680803 0.03275067335650486 0.0327492557116407 1.8758773372386065e-07 6.726795563346122 -0.06401958110469841 YTQVGPDHNR ddPTM_A459_Selumetinib_30min_R2 4 YTQVGPDHNR 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 ;;; 147.28 0.0011671 13739100.0 105146.0 99828.0 123706.0 128514.0 128094.0 93255.0 97034.0 97301.0 89858.0 106259.0 False True 99302.40625278743 107484.48660238783 115746.89064090898 111010.17150098454 112001.6865451105 106100.02976539549 101546.27326922341 97584.12980095235 107832.11084229637 103191.02657596178 0.9623162938464245 1.0416069126249607 1.1216759294055911 1.0757734968288823 1.085382036224467 1.028190466612834 0.9840610820406209 0.9456648803577699 1.0449756574804319 1.0 16.654957994837247 -7.042675122040262 3.9394886215241387 0.989894018877751 1.0610352817890658 0.3083418872753303 0.04449363568827097 0.2711263534003572 8.8645491766017 0.018165284278968723 0.014420347851708218 9.064103959389423e-08 7.042675122040262 0.07114126291131484 YTVQDESHSEWVSCVR ddPTM_A459_Selumetinib_30min_R1 2 YTVQDESHSEWVSCVR 16 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6R9L0;D6R9Z1;D6RFZ9;D6RHH4;D6RFX4;D6RBD0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 ; 154.46 0.00015916 19391700.0 3318.1 3940.7 2868.1 3556.7 3165.1 3335.6 3070.2 2429.3 1886.1 2444.7 False True 3395.4052741013156 3479.3210120182716 2478.6277733455913 2935.589112527796 2878.8172638437923 3302.0468924824786 2838.6123421677985 2364.867072521499 3200.573944706336 2758.501058394549 1.2308877909502944 1.2613085651825853 0.898541534288247 1.064197203620546 1.0436165159636617 1.1970439099284862 1.0290415997954607 0.8573014918101406 1.1602583711057461 1.0 11.42966881867316 -5.238965644537335 24.68972692439705 1.0336143774864712 1.2460982527505695 0.4379461256441616 0.09732817373214138 639.4176590672334 702463.4480851807 0.024802041664672814 0.06551333385380649 5.7681209110177835e-06 5.238965644537335 0.2124838752640983 YTVQDESHSEWVSCVR ddPTM_A459_Selumetinib_30min_R2 2 YTVQDESHSEWVSCVR 16 0 P63244;J3KPE3;H0Y8W2;H0YAM7;H0YAF8;D6R9L0;D6R9Z1;D6RFZ9;D6RHH4;D6RFX4;D6RBD0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 ; 82.837 0.027292 10384800.0 36890.0 37583.0 35717.0 40628.0 57767.0 33881.0 29438.0 31366.0 25792.7 54917.0 False True 34839.801482370545 40465.495251608125 33419.00710572925 35094.3963127908 50509.79301646763 38547.80020890429 30806.925330290374 31457.269867079183 30951.96070825183 53331.40351849823 0.6532699157314735 0.7587554907976966 0.6266290571958738 0.6580437415381006 0.947092888694521 0.7227974076387061 0.5776507516740087 0.5898451529813592 0.5803702634136754 1.0 15.702697675365838 -7.037328104124304 23.374826521863177 0.652420782351322 0.7322345679893167 0.0 0.1432719557235421 813.4450320960453 509375.0604084016 0.05347881538787477 0.04144153094358475 9.176390695425553e-08 7.037328104124304 0.0798137856379948 YVASVLGLTPS(ph)PR ddPTM_A459_Selumetinib_30min_R1 2 YVASVLGLTPSPR 13 0 Q99666;O14715;F8W705;Q99666-2;C9J1W9;C9JF75 Q99666 RGPD5;RGPD8;RGPD6 RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 YVASVLGLT(0.001)PS(0.999)PR;YVASVLGLTPS(1)PR 209.19 8.744e-06 69603000.0 2261.5 2823.7 3055.2 3280.7 2998.8 2498.1 2128.3 2520.6 1395.6100000000001 1789.7600000000002 True False 2314.1885498870192 2493.0998912974824 2640.320621012324 2707.7873313661344 2727.5590694811403 2472.971382093322 1967.7606174958407 2453.7454999373012 2368.24823867855 2019.493129738713 1.1459254383234445 1.2345176393940225 1.3074174812141774 1.3408252256428694 1.3506156714848734 1.224550529871464 0.9743834175610365 1.2150303775753735 1.1726943775168772 1.0 10.979777522701726 -7.0136703072294955 23.945895509279154 1.107163463029797 1.2797915603833256 0.5049670203447378 0.0863240067179705 340.8336875071548 597028.5817219171 0.03307997361292372 0.026787263017873524 9.690131992730915e-08 7.0136703072294955 0.17262809735352858 YVASVLGLTPS(ph)PR ddPTM_A459_Selumetinib_30min_R2 2 YVASVLGLTPSPR 13 0 Q99666;O14715;F8W705;Q99666-2;C9J1W9;C9JF75 Q99666 RGPD5;RGPD8;RGPD6 RANBP2-like and GRIP domain-containing protein 5/6;RANBP2-like and GRIP domain-containing protein 8 1 YVASVLGLTPS(1)PR;YVASVLGLT(0.015)PS(0.985)PR 150.26 0.00049716 16516600.0 40495.0 41293.0 46071.0 43367.0 47524.0 42710.0 37141.0 44464.0 40430.0 41310.0 True False 38244.450014328955 44460.04032207796 43106.84201831209 37460.33978775227 41553.61025004944 48592.91481722208 38868.130093495296 44593.38287858857 48517.12970858509 40117.27296373005 0.9533162946770009 1.1082518086978195 1.0745207446499392 0.9337708428391953 1.035803462703409 1.2112716350673896 0.9688627172798085 1.111575627757783 1.2093825458288088 1.0 15.291935919312616 -6.550859355192484 24.977143557795316 1.1017106304179252 1.0226202950217822 0.17503461293655198 0.08626208672974846 396.6134532181707 354037.71258464485 0.028161721162685973 0.028162168426981153 2.812811602494265e-07 6.550859355192484 -0.07909033539614296 YVASYLLAALGGNS(ph)SPSAK ddPTM_A459_Selumetinib_30min_R1 2 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 YVASYLLAALGGNS(0.5)S(0.5)PSAK;YVASYLLAALGGNS(0.928)S(0.072)PSAK 300.18 3.1139999999999983e-100 308440000.0 12914.5 14546.2 17033.3 18186.1 14082.7 13146.0 14118.1 13122.5 8029.5 11838.2 True False 13215.382722757426 12843.124141655082 14720.271417219574 15010.239030376957 12808.922271502626 13013.763175612981 13053.160350452483 12774.448672112698 13625.475048523163 13357.74828383292 0.9893420988290518 0.9614737355995325 1.1020024561351958 1.123710277468252 0.9589132838358284 0.9742482714218931 0.9771976588487534 0.9563324896287948 1.0200428065420486 1.0 13.705389212695577 -6.332164695548031 24.9998414689231 0.9783990555031766 1.0423643442314137 0.29518951216150446 0.047554874314219675 218.7833788926476 77334.26743530139 0.016074693173143265 0.018226989360376075 4.65409564871634e-07 6.332164695548031 0.06396528872823704 YVDEENS(ph)DGETSNHR ddPTM_A459_Selumetinib_30min_R1 7 YVDEENSDGETSNHR 15 0 A0A494C108;Q8N9T8;H0YFD2;F8WFC1;H0YH26 A0A494C108 KRI1 Protein KRI1 homolog 1 YVDEENS(1)DGETSNHR;YVDEENS(1)DGETSNHR;YVDEENS(0.77)DGET(0.23)SNHR;YVDEENS(1)DGETSNHR;YVDEENS(1)DGETSNHR;YVDEENS(0.972)DGET(0.016)S(0.013)NHR;YVDEENS(0.999)DGET(0.001)SNHR 338.92 7.479199999999994e-146 192857500.0 23787.27 28304.75 26149.1 29037.25 31129.68 23548.38 27417.63 23434.260000000002 10893.24 18286.34 True False 24341.467109029847 24990.81671147871 22598.195846724713 23966.439384189747 28314.005940391402 23311.504677418317 25349.49609503944 22812.70729959562 18485.03266922903 20633.569863035387 1.1797021683890523 1.2111727091999354 1.0952150304930468 1.1615265580933296 1.3722301147275227 1.1297853368156323 1.22855600186047 1.1056112660593993 0.8958717658617369 1.0 14.33270582647166 -8.062131360742669 3.864082844599546 0.9517878564899981 1.1955862467755918 0.6405493482547945 0.07375295200472322 0.14750339528001088 4.24852831346509 0.05441163204503301 0.0195009195968437 8.666996860712057e-09 8.062131360742669 0.2437983902855937 YVDEENS(ph)DGETSNHR ddPTM_A459_Selumetinib_30min_R2 2 YVDEENSDGETSNHR 15 0 A0A494C108;Q8N9T8;H0YFD2;F8WFC1;H0YH26 A0A494C108 KRI1 Protein KRI1 homolog 1 YVDEENS(1)DGETSNHR;YVDEENS(1)DGETSNHR 135.18 0.00040717 0.0 24683.0 19618.3 32740.0 32319.0 38032.0 26153.1 22757.0 26594.0 21813.4 29294.0 True False 23311.217673877807 21122.96052722306 30633.544044616745 27917.096446615305 33254.080149606125 29755.45213079586 23815.245592140032 26671.38413712631 26176.68951732006 28448.206105047408 0.8194266305509446 0.7425058876902375 1.0768181280569957 0.981330645016036 1.1689341685311412 1.0459517911576335 0.8371440190007139 0.9375418625216637 0.9201525544584576 1.0 14.79605006108134 -5.254406350739363 24.994927508900048 0.9955186433357932 0.7809662393723428 0.49149780272778953 0.08748126959898662 490.29438629502175 1742463.3444488288 0.024481594180168553 0.06192898725819012 5.566646579185696e-06 5.254406350739363 -0.21455240396345043 YVDIAIPCNNK ddPTM_A459_Selumetinib_30min_R2 2 YVDIAIPCNNK 11 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 ; 160.82 0.0083696 7424900.0 50359.0 63316.0 55354.0 64131.0 66667.0 48698.0 46688.0 49560.0 38228.0 59710.0 False True 47560.24838304956 68172.13360697178 51792.58390487826 55396.24716785434 58291.69544945804 55405.707463570136 48859.08451051692 49704.21139490033 45874.66817956441 57986.01715478868 0.8202020196712524 1.1756650474025858 0.8931909181936468 0.9553380260620216 1.005271586318015 0.9555011739411137 0.8426011460675391 0.8571758129588246 0.7911332840313198 1.0 15.82341742783239 -7.176261830412686 4.720166376386701 0.8609573821261667 0.9763981074465768 0.17679670998294061 0.09849356382672786 0.3258216250211606 12.725483875043283 0.03659487162945584 0.027873149519275997 6.664048813694945e-08 7.176261830412686 0.11544072532041016 YVEQYVGTEGASSS(ph)PTEGFLLKPVFLQR ddPTM_A459_Selumetinib_30min_R1 1 YVEQYVGTEGASSSPTEGFLLKPVFLQR 28 1 M0QYC5;O75182-2;O75182 M0QYC5 SIN3B Paired amphipathic helix protein Sin3b 1 YVEQYVGTEGAS(0.055)S(0.202)S(0.743)PTEGFLLKPVFLQR 160.36 1.0883e-17 29582000.0 1492.7 1715.4 1698.6 2165.3 1751.8 1545.6 1638.7 1407.7 864.57 1355.8 True False 1527.4770057114113 1514.560170532175 1467.9394497419273 1787.1710027149984 1593.349999305409 1530.0526672925166 1515.0915396750609 1370.363223145974 1467.112144305582 1529.830136610353 0.998461835178541 0.9900185218523596 0.9595440791841393 1.1682153200843826 1.0415208598490528 1.0001454610396527 0.9903658605079199 0.8957616864459801 0.9590032966380598 1.0 10.579155758054235 -7.321125427091433 2.3735778740994418 0.9464713558439506 1.0309073656001342 0.24589032449198667 0.05786229498245165 0.4225855919148654 4.661434911897204 0.030112920894218288 0.01893437286057035 4.773913799884247e-08 7.321125427091433 0.0844360097561836 YVEVS(ph)PATER ddPTM_A459_Selumetinib_30min_R1 1 YVEVSPATER 10 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 YVEVS(0.928)PAT(0.072)ER 97.452 0.020615 4026200.0 2118.0 2163.7 2157.4 2282.6 2523.2 1945.6 2515.5 2278.8 1087.8 1812.6 True False 2167.3452790894144 1910.3729981231595 1864.436929749932 1883.9867597087025 2294.9770055071403 1926.029030463459 2325.7538097593315 2218.358821414397 1845.9171502314573 2045.2648662191514 1.0596892925149295 0.9340467485048276 0.9115870323419306 0.9211456133754523 1.122092812237861 0.9417015186027666 1.1371406452889832 1.0846315594885394 0.9025320782260317 1.0 10.998071972052603 -6.234382136879339 24.934456651193987 1.0363884972177493 0.9517885577178735 0.17381778342877585 0.07908438971192057 1171.7884170624327 1079854.8589742994 0.023005988171571748 0.029692708236949743 5.82931955155533e-07 6.234382136879339 -0.08459993949987576 YVEVS(ph)PATER ddPTM_A459_Selumetinib_30min_R2 1 YVEVSPATER 10 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 YVEVS(0.5)PAT(0.5)ER 84.31 0.03805 3673400.0 16384.0 17969.0 22759.0 24390.0 25990.0 19227.0 17660.0 23133.0 19031.0 18536.0 True False 15473.442870348574 19347.16452055842 21294.710718125607 21068.03992490322 22724.90384645202 21875.344724671726 18481.22499262614 23200.313200125678 22837.731770568447 18000.817517688207 0.8595966741590403 1.074793658762845 1.1829857559080696 1.1703935059727737 1.2624373212006492 1.2152417357254068 1.0266880920528119 1.2888477524605908 1.2687052545323192 1.0 14.135774808433954 -4.744327716463641 1.8230425221313313 1.1873694698147408 0.730603343964929 0.5221837136973657 0.09201807475210033 0.7294367325538695 2.331968294940826 0.024579070052260045 0.5966457133644691 1.8016577058106277e-05 4.744327716463641 -0.4567661258498118 YVGFGNT(ph)PPPQK ddPTM_A459_Selumetinib_30min_R1 1 YVGFGNTPPPQK 12 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHT6;E5RHC5;F8W1U7;Q8N6T3-3 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 YVGFGNT(1)PPPQK 141.58 0.0022915 13541000.0 2772.5 3708.1 2855.0 3253.6 3102.9 2698.9 3507.6 3208.0 1459.7 2748.0 True False 2837.093855654109 3273.9539281510774 2467.3066813924415 2685.4198376361333 2822.2432428614893 2671.7515164051347 3243.018908015037 3122.913418947419 2477.004287730151 3100.73256778673 0.9149753465127747 1.0558646566827241 0.7957173433868818 0.8660598032654448 0.9101859580479642 0.8616517090708672 1.045887975540525 1.0071534228366303 0.7988448644244771 1.0 11.598393386308969 -7.232422111660363 24.950136019870627 0.9635677375346483 0.9018723775029971 0.10982013391763856 0.08675300343988235 1715.888799646467 1475387.571518028 0.03379748062558835 0.026174730443784103 5.8556874545518784e-08 7.232422111660363 -0.061695360031651214 YVGFGNT(ph)PPPQK ddPTM_A459_Selumetinib_30min_R2 4 YVGFGNTPPPQK 12 0 F8VWH9;Q8N6T3-5;Q8N6T3;Q8N6T3-2;Q8N6T3-4;E5RHT6;E5RHC5;F8W1U7;Q8N6T3-3 F8VWH9 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 YVGFGNT(1)PPPQK;Y(0.033)VGFGNT(0.967)PPPQK;Y(0.001)VGFGNT(0.999)PPPQK;Y(0.001)VGFGNT(0.999)PPPQK 124.42 0.0071498 46523500.0 354636.0 306917.0 368796.0 379102.0 401241.0 312025.0 335024.0 324152.0 319088.0 321515.0 True False 334926.7508403896 330456.5470063006 345068.0668747242 327467.65361257276 350833.5184399484 355003.6114690638 350603.27983746206 325095.2286537478 382914.5160636406 312232.0265537079 1.0726854465801505 1.0583685173290762 1.1051655100325464 1.0487958497628498 1.123630789295731 1.136986539745623 1.1228933934397465 1.0411975742591777 1.2263780890451812 1.0 18.252259000799597 -6.273595743430239 24.20951130121307 1.112716834275146 1.0727557133738004 0.08789957465579967 0.05777727328612452 1182.0891077612396 2354136.0484161107 0.016747261634492503 0.019121666512365448 5.326037949340329e-07 6.273595743430239 -0.039961120901345515 YVSGS(ph)SPDLVTR ddPTM_A459_Selumetinib_30min_R1 5 YVSGSSPDLVTR 12 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 YVS(0.017)GS(0.63)S(0.353)PDLVTR;YVS(0.001)GS(0.656)S(0.343)PDLVTR;YVS(0.123)GS(0.848)S(0.028)PDLVTR;YVSGS(0.643)S(0.357)PDLVTR;YVS(0.076)GS(0.876)S(0.048)PDLVTR 235.31 8.2986e-11 178025000.0 15495.2 19722.3 14685.0 15564.6 16091.28 13916.92 16087.8 15354.980000000001 8107.9400000000005 12429.6 True False 15856.208011589379 17413.203947351485 12690.85765893099 12846.534793727355 14635.826565146222 13776.928420352346 14874.284293637906 14947.71605039565 13758.581999492231 14025.060234556744 1.1305625606170886 1.241577836824301 0.9048701001412904 0.9159700264298625 1.0435482144372252 0.9823079680190593 1.0605504749982275 1.0657862283946238 0.9809998509376858 1.0 13.77571934645551 -5.254507063879681 24.999901223202617 0.9975093387141496 1.186070208491564 0.6428564862433044 0.05714739233769907 351.17164175644024 1266416.4657451513 0.015510150332000715 0.03913077962702936 5.565355820309662e-06 5.254507063879681 0.18856086977741437 YVSGS(ph)SPDLVTR ddPTM_A459_Selumetinib_30min_R2 6 YVSGSSPDLVTR 12 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 YVS(0.001)GS(0.499)S(0.499)PDLVTR;YVSGS(0.5)S(0.5)PDLVTR;YVS(0.011)GS(0.494)S(0.494)PDLVTR;YVSGS(0.964)S(0.035)PDLVTR;YVSGS(0.5)S(0.5)PDLVTR;Y(0.001)VS(0.382)GS(0.554)S(0.063)PDLVTR 205.31 1.8494e-05 162974000.0 269462.0 243427.0 326949.0 372616.0 416092.0 312048.0 289764.0 302289.0 293903.0 365654.0 True False 254486.38078185238 262097.06815882734 305913.4572951558 321865.058001548 363818.8030503238 355029.7795102907 303238.6001564729 303168.6109433624 352691.8123359462 355096.61893681216 0.7166679917815187 0.7381007145141709 0.8614935794406753 0.9064154397336642 1.024562847541682 0.9998117711547873 0.8539608207602586 0.8537637216909404 0.993227740077993 1.0 18.437852098196664 -5.413454389103773 1.8854532651744353 0.9441532893775327 0.7123626730142346 0.7055017591555741 0.056787621936433705 0.22680610414565627 1.511004421937572 0.018081500597402638 0.0577139485790324 3.8596294444088306e-06 5.413454389103773 -0.23179061636329812 YVSGSS(ph)PDLVTR ddPTM_A459_Selumetinib_30min_R1 1 YVSGSSPDLVTR 12 0 Q15678 Q15678 PTPN14 Tyrosine-protein phosphatase non-receptor type 14 1 YVS(0.056)GS(0.304)S(0.64)PDLVTR 131.79 0.0019749000000000004 10932000.0 1966.0 2265.7 2079.0 1901.5 2533.6 2022.3 2133.8 2275.5 1186.3 1638.0 True False 2011.8039748299282 2000.4307907046455 1796.6832191295573 1569.4387205757032 2304.436327343412 2001.957498101486 1972.8457480677641 2215.1463481343058 2013.0644560760973 1848.2532554711302 1.0884893446688981 1.0823358675457733 0.9720979599581837 0.8491470072783096 1.2468184868723513 1.083161894710785 1.0674109417785793 1.1985080191673476 1.0891713298040187 1.0 10.851946739131877 -6.269369821525355 24.95681681705974 1.1202146347087711 1.0021888814754694 0.2864951103260307 0.08940546918532888 778.4216300852895 2449661.1076294472 0.02806155086461545 0.03241005024192513 5.378116163906702e-07 6.269369821525355 -0.11802575323330178 YVSQNCVT(ph)SPMNIDR ddPTM_A459_Selumetinib_30min_R1 1 YVSQNCVTSPMNIDR 15 0 A0A0C4DGF8;A0A1B0GV09;Q9H9B1-3;Q9H9B1;A0A1B0GWF6 A0A0C4DGF8 EHMT1 Histone-lysine N-methyltransferase EHMT1 1 YVSQNCVT(0.894)S(0.106)PMNIDR 167.92 8.3716e-06 0.0 885.58 1016.5 928.15 1049.8 963.47 776.48 848.47 773.78 451.21 715.84 True False 906.212290961286 897.4877074419702 802.11232796301 866.4721371866275 876.3243086144438 768.6693161874309 784.4692247928838 753.2568408083334 765.6704149254796 807.7250368720722 1.1219316594055413 1.1111302317896512 0.9930512134045052 1.0727315579346832 1.0849289902019421 0.9516472575421393 0.9712082565011889 0.932565918379022 0.947934482618677 1.0 9.657720448775263 -6.763129229841119 24.999958018942795 0.9571151036652513 1.073790785393801 0.7192133200595341 0.036208309936363474 25.588604071142676 378555.99641954806 0.012992347917312979 0.012061547665559601 1.7253244233957523e-07 6.763129229841119 0.11667568172854959 YVSQNCVTS(ph)PMNIDR ddPTM_A459_Selumetinib_30min_R2 2 YVSQNCVTSPMNIDR 15 0 A0A0C4DGF8;A0A1B0GV09;Q9H9B1-3;Q9H9B1;A0A1B0GWF6 A0A0C4DGF8 EHMT1 Histone-lysine N-methyltransferase EHMT1 1 YVSQNCVT(0.003)S(0.997)PMNIDR;YVSQNCVT(0.08)S(0.92)PMNIDR 218.34 2.8662e-09 13405600.0 41462.0 46087.0 45749.0 55808.0 64142.0 42506.0 43953.0 40096.0 33455.0 48258.0 True False 39157.70802553665 49621.72470693837 42805.559147745 48206.85412583022 56083.90852324452 48360.815668949734 45996.90159121725 40212.672721749856 40146.93481080171 46864.66615065804 0.8355486391315481 1.0588302186431262 0.9133866228799318 1.0286396572389396 1.1967205387305855 1.0319248944072694 0.9814836073588756 0.858059515296157 0.8566567972924307 1.0 15.516212984994006 -7.608115662716853 4.850501958934238 0.8940688763426274 1.0171197370897898 0.19115548310151698 0.09597569104498614 0.3145349764153303 12.981670132816742 0.04834951403328557 0.02714857562917742 2.4653826610771832e-08 7.608115662716853 0.12305086074716232 YWEEETVPTTAGAS(ph)PGPPR ddPTM_A459_Selumetinib_30min_R1 1 YWEEETVPTTAGASPGPPR 19 0 O15213 O15213 WDR46 WD repeat-containing protein 46 1 YWEEET(0.003)VPT(0.39)T(0.189)AGAS(0.418)PGPPR 130.95 0.00055617 0.0 603.38 729.26 551.36 426.52 690.5 657.5 698.43 618.63 257.7 646.62 True False 617.4375800268981 643.8779001762241 476.48834040369024 352.03628877199486 628.0443969176761 650.8861469622344 645.7468627907807 602.2219228065594 437.29807833668576 729.6199756121746 0.8462454437446674 0.8824839254654313 0.6530637267762595 0.4824926681545761 0.8607828978239345 0.8920892638885333 0.885045481723521 0.8253912213701056 0.5993504741557804 1.0 9.511001418074143 YWEEETVPTTAGAS(ph)PGPPR ddPTM_A459_Selumetinib_30min_R2 2 YWEEETVPTTAGASPGPPR 19 0 O15213 O15213 WDR46 WD repeat-containing protein 46 1 YWEEETVPT(0.018)T(0.088)AGAS(0.894)PGPPR;YWEEETVPT(0.006)T(0.014)AGAS(0.98)PGPPR 171.25 3.0381e-09 8121600.0 26863.0 19977.0 28408.0 28731.0 34661.0 32071.0 34890.0 33121.0 36124.0 26870.0 True False 25370.06200110925 21509.17166382078 26580.260208291744 24817.78823626052 30306.575306728497 36488.48913844836 36512.454133223444 33217.376626523284 43349.80938889257 26094.19328335577 0.9722493324708985 0.8242895816035993 1.018627398044377 0.9510847094127487 1.1614298621011443 1.3983375052917468 1.3992559086512546 1.2729796344273672 1.6612818383829222 1.0 14.671441180469662 -6.469133903373491 2.3194030481213166 1.3681348941244675 0.9326837750058423 0.5846736904187115 0.15981096978384757 0.19700310867022752 2.1048480059330106 0.053074143636912874 0.05905535953339524 3.39520574139198e-07 6.469133903373491 -0.4354511191186252 YWGPAS(ph)PTHK ddPTM_A459_Selumetinib_30min_R2 4 YWGPASPTHK 10 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3;Q9H6S3-2 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 1 YWGPAS(1)PTHK;YWGPAS(0.72)PT(0.28)HK;YWGPAS(0.998)PT(0.002)HK;YWGPAS(0.916)PT(0.084)HK 122.34 0.0029728000000000003 629443000.0 588754.0 501408.0 611459.0 582203.0 641700.0 535331.0 613793.0 707405.0 645285.0 717622.0 True False 556033.4096489999 539864.3813191691 572118.393646221 502905.9470438048 561083.9091292132 609067.9859990235 642335.5907077562 709463.4314327976 774360.0307693387 696902.3882541229 0.7978641184484567 0.7746628371752824 0.8209448027283845 0.7216303969106531 0.8051111871417722 0.8739645555310238 0.9217009462644156 1.0180241069486682 1.11114561209822 1.0 19.410597073366212 -7.389877099093841 1.277765421996273 1.0595223894580925 0.7810653683721193 0.8964411816939498 0.03814046338709686 0.13161484587031602 0.41152277972267765 0.026004708622645686 0.013437048314873655 4.074955785788881e-08 7.389877099093841 -0.27845702108597326 YWPQEAGEYAVHVLCNSEDIR ddPTM_A459_Selumetinib_30min_R1 2 YWPQEAGEYAVHVLCNSEDIR 21 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 ; 137.86 3.9838e-05 16353700.0 1097.1799999999998 961.3399999999999 1436.71 1315.2 1423.13 1013.6499999999999 1256.49 1129.33 911.69 812.52 False True 1122.742159259359 848.7858658851591 1241.6126732831294 1085.5250093616423 1294.4081427740093 1003.453601320562 1161.7119476940973 1099.3764998191673 1547.0713427969463 916.8148566150194 1.2246116554051552 0.9257985511043846 1.3542676193831533 1.1840176907358584 1.411853367596055 1.094499717233447 1.2671172803451993 1.1991259651683497 1.6874413973928202 1.0 9.840486612350292 -5.274500032601151 24.834131510316844 1.2768422557306913 1.0752050870127126 0.14960294393928975 0.19028931687328665 1106.6676859803968 2104270.0103214956 0.04694017554603384 0.09867020446884128 5.3149595960887965e-06 5.274500032601151 -0.20163716871797877 YWQQVIDMNDYQR ddPTM_A459_Selumetinib_30min_R1 1 YWQQVIDMNDYQR 13 0 O60701;O60701-2;O60701-3 O60701 UGDH UDP-glucose 6-dehydrogenase 0 169.99 0.035392 50006000.0 725.21 794.57 1125.2 1135.1 877.12 951.54 735.93 784.23 448.29 865.92 False True 742.1059819869853 701.5413750144284 972.4040202811824 936.876093465937 797.7846508681138 941.9683715291939 680.4182075993581 763.4296728619502 760.7153881938409 977.0692667750681 0.7595223872268476 0.7180057738689787 0.9952252653393922 0.9588635374421371 0.8165077727818579 0.9640753256299537 0.6963868691164121 0.7813465215027585 0.7785685355805648 1.0 9.932317031692682 -9.790560043588362 14.264021094770612 0.9999634681042555 0.8334093244455353 0.2019154072548951 0.10126839869868245 0.0 0.0 0.10373977838326044 0.02516059199131474 1.619720043264517e-10 9.790560043588362 -0.16655414365872023 YWSQQIEESTTVVTTQSAEVGAAETTLTELRR ddPTM_A459_Selumetinib_30min_R1 1 YWSQQIEESTTVVTTQSAEVGAAETTLTELRR 32 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 128.25 1.3356e-18 8370600.0 390.54 643.52 411.48 307.5 356.13 421.82 457.13 531.17 274.13 459.36 False True 399.63882214144473 568.1763792356682 355.6032760978501 253.8008974898913 323.9181043798583 417.57687378191616 422.6483160625258 517.0816461166771 465.17858833696425 518.3233305453107 0.7710222530809062 1.0961813712647446 0.6860645761859335 0.4896574831444995 0.624934447845662 0.8056300945253564 0.8154144163602892 0.9976044211104154 0.8974679720620822 1.0 9.017708522923327 -7.534214658580013 2.2672744773001594 0.9626571911071143 0.7405665698131625 0.3021815929921551 0.1480104502873937 0.4572833693444668 4.678934681909975 0.09515514183407957 0.049858997543148244 2.922707415211458e-08 7.534214658580013 -0.22209062129395185 YYDSRPGGYGYGYGR ddPTM_A459_Selumetinib_30min_R1 1 YYDSRPGGYGYGYGR 15 1 P98179 P98179 RBM3 RNA-binding protein 3 0 96.23 0.029048 37933000.0 2914.7 3230.0 4032.7 4374.1 3277.1 3389.1 3663.9 2619.1 1608.5 2489.9 False True 2982.606838981074 2851.8300984137395 3485.0814900354812 3610.2455470261284 2980.6868836189956 3355.008731056592 3387.529073177189 2549.6329599642104 2729.5070198081467 2809.5029186798324 1.0616137179108474 1.0150657183704925 1.240461957474349 1.285012207327608 1.0609303388869948 1.1941645295150962 1.2057396526104935 0.9075032252190244 0.9715266717326368 1.0 11.45609918372296 -7.762375963573384 24.99993816311528 0.954636181724567 1.1532538196120936 0.525407878090781 0.08365177148814408 20.621281211985373 550376.1244207165 0.045500956665864 0.02383371051763021 1.7283195257328288e-08 7.762375963573384 0.19861763788752662 YYGGGS(ph)EGGR ddPTM_A459_Selumetinib_30min_R2 2 YYGGGSEGGR 10 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 YYGGGS(1)EGGR;YYGGGS(1)EGGR 98.754 0.019224 23516000.0 36411.0 31107.0 44368.0 50409.0 49568.0 44815.0 39001.0 40469.0 35595.0 39955.0 True False 34387.42238478159 33492.80687523014 41513.41118422587 43543.20723962469 43340.824696457625 50987.859459934596 40814.62377901538 40586.75808999639 42714.99460739764 38801.39533444284 0.8862419015704032 0.8631856299636621 1.0698948021432533 1.1222072521957138 1.1169913948425785 1.314072832186893 1.0518854651287621 1.0460128492845395 1.1008623334089436 1.0 15.243820913556831 -5.33271041641439 3.664589753696906 1.114967501061041 0.8713499091919851 0.5717866929603814 0.07910846531050625 0.15909118876851386 4.137549458689902 0.02199815804397344 0.052908960091163804 4.648251130437783e-06 5.33271041641439 -0.24361759186905585 YYGGGS(ph)EGGRAPK ddPTM_A459_Selumetinib_30min_R1 3 YYGGGSEGGRAPK 13 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 YYGGGS(1)EGGRAPK;YYGGGS(1)EGGRAPK;YYGGGS(1)EGGRAPK 203.85 0.00023521 15618700.0 3016.6900000000005 3585.65 5941.9 5873.0 3512.89 3878.0700000000006 3348.04 3320.75 2037.8899999999999 2539.01 True False 3086.973007543081 3165.8404310765386 5135.022616520403 4847.390799863845 3195.1497197511017 3839.060136805831 3095.494647277532 3232.6729226838033 3458.150488403372 2864.9166655517442 1.0775088311158858 1.1050375283662364 1.7923811461131862 1.6919831763868438 1.115267944150047 1.3400250635445552 1.080483311957481 1.1283654291079472 1.2070684393667621 1.0 11.484277459265984 -6.307211522779967 24.965096000133325 1.1581251476904737 1.4212968288831092 0.26080802672448744 0.22325369446065702 670.7750168542611 365853.14655872673 0.07567587404603979 0.08580860985462054 4.929336625333584e-07 6.307211522779967 0.26317168119263545 YYGGGS(ph)EGGRAPK ddPTM_A459_Selumetinib_30min_R2 2 YYGGGSEGGRAPK 13 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 YYGGGS(1)EGGRAPK;YYGGGS(1)EGGRAPK 119.25 0.012643 4152000.0 17602.4 20521.6 20219.0 21791.0 20914.5 10263.1 8666.2 10836.5 6448.200000000001 17052.5 True False 16624.12907599022 22095.540732655772 18918.131552782706 18823.028208428295 18287.033531997706 11676.74886585418 9069.195471749517 10868.032420920852 7738.020177761524 16560.15001728412 1.003863434729717 1.3342596962946753 1.1423888994385631 1.136645995886654 1.104279460808701 0.7051112975224834 0.547651770200381 0.6562762058059677 0.4672675168815027 1.0 14.015428121723133 -6.765357739452793 3.6132743914184995 0.6365101589030668 1.1622181816691708 0.7092802203386503 0.1499753768804593 0.11166101214601327 3.1149882420582125 0.050605473328011664 0.04708902033229204 1.716493884819689e-07 6.765357739452793 0.525708022766104 YYLHDDR ddPTM_A459_Selumetinib_30min_R1 2 YYLHDDR 7 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 0 ; 102.77 0.026783 13313400.0 6584.799999999999 7476.0 6937.9 5014.3 7317.3 5704.8 7690.0 6738.5 3795.0 6142.7 False True 6738.213028209619 6600.706444501892 5995.77128715678 4138.646635068494 6655.451506974244 5647.414891543969 7109.937108745479 6559.773090267206 6439.837824166559 6931.175379964905 0.972160226631538 0.9523213715788726 0.8650439439879155 0.5971060329870703 0.9602197523687451 0.8147845901963837 1.025790968916657 0.9464156843049641 0.9291119429442523 1.0 12.758884308173178 -7.257569102858482 24.705621535599978 0.970864289628441 0.8572544929167729 0.22561092734119148 0.10420715101849239 482.7112488619888 3081367.6646637027 0.04290249643961375 0.03195493878984824 5.5262546982978345e-08 7.257569102858482 -0.11360979671166804 YYLHDDR ddPTM_A459_Selumetinib_30min_R2 2 YYLHDDR 7 0 Q9Y2W1;A0A3B3ITZ9 Q9Y2W1 THRAP3 Thyroid hormone receptor-associated protein 3 0 ; 89.14200000000002 0.04405 14984600.0 51086.0 47285.0 58484.0 62045.0 65032.0 48316.0 45854.0 44234.0 45813.0 56442.0 False True 48246.84463346115 50911.60745476122 54721.20311256461 53594.36396640507 56862.0987665436 54971.090431020864 47986.30185797726 44362.7136166671 54976.88012217182 54812.37280607239 0.8802181362255517 0.9288342184142954 0.9983366950044228 0.9777785784976567 1.037395315246125 1.0028956532407387 0.8754647792343173 0.8093558323706135 1.0030012806904285 1.0 15.74221396928905 -9.64187039609206 10.95421537228271 1.0000009779450334 0.9461736040817813 0.0531751360198528 0.06845265323085918 0.0 0.0 0.07186713008003329 0.017430339313528324 2.2810226824133525e-10 9.64187039609206 -0.05382737386325209 YYMSDDISRDS(ph)DGMDEQCR ddPTM_A459_Selumetinib_30min_R1 2 YYMSDDISRDSDGMDEQCR 19 1 P46100-4;P46100;P46100-5;P46100-3;P46100-6;A0A096LNL9;A0A096LNW1;A0A096LNL6;A0A096LNN3 P46100-4 ATRX Transcriptional regulator ATRX 1 YYMSDDIS(0.014)RDS(0.986)DGMDEQCR;YYMS(0.001)DDIS(0.02)RDS(0.979)DGMDEQCR 87.669 0.0018172 14638800.0 1024.77 1632.3000000000002 1351.51 1623.39 1372.48 1293.43 1323.3000000000002 1275.64 696.0999999999999 870.81 True False 1048.6451471446921 1441.189557164317 1167.9823653130297 1339.8954113044392 1248.3394263310242 1280.4192685404764 1223.4824156050586 1241.8058833373088 1181.2308588675469 982.5869459077007 1.0672288610306824 1.4667298025549944 1.1886809306570454 1.3636405581051778 1.2704620507428224 1.3031104004314267 1.245164532971504 1.2638127226391604 1.2021642092714162 1.0 9.940441262163752 -8.948165488635166 0.9497760939009999 0.9990202186342632 1.2835109989008038 0.4051080525261447 0.09866180190736298 1.2977639845891122 1.9041049186545125 0.08719066859159012 0.028188528144010218 1.126768017533087e-09 8.948165488635166 0.2844907802665406 YYMSDDISRDS(ph)DGMDEQCR ddPTM_A459_Selumetinib_30min_R2 2 YYMSDDISRDSDGMDEQCR 19 1 P46100-4;P46100;P46100-5;P46100-3;P46100-6;A0A096LNL9;A0A096LNW1;A0A096LNL6;A0A096LNN3 P46100-4 ATRX Transcriptional regulator ATRX 1 YYMS(0.002)DDIS(0.006)RDS(0.992)DGMDEQCR;YYMS(0.002)DDIS(0.016)RDS(0.983)DGMDEQCR 80.508 0.0034538000000000004 31849000.0 38812.0 46726.0 47581.0 48984.0 56249.0 38937.0 35233.0 34082.0 35473.0 48818.0 True False 36654.984416746134 50309.733952229544 44519.69026227577 42312.294697886784 49182.49774755983 44300.218315106 36871.404312865045 34181.17297742118 42568.5911984328 47408.49749560335 0.773173299156876 1.0611965493505728 0.9390656235499663 0.8925044439936283 1.037419457389912 0.9344362436125379 0.7777383013727548 0.7209925389555139 0.8979105739932087 1.0 15.532858050403442 -7.179853807063458 6.770798867249116 0.826210770456901 0.9481559594240827 0.14251659365212377 0.10169150479261153 0.35727636667985846 25.081761482774198 0.03747488660920776 0.02892960797967855 6.609158891807987e-08 7.179853807063458 0.12194518896718176 YYNSDVHR ddPTM_A459_Selumetinib_30min_R1 1 YYNSDVHR 8 0 K7EL89;P19623 K7EL89 SRM Spermidine synthase 0 141.48 0.0031971 2830500.0 1631.4 1597.4 2048.5 2200.0 2136.3 2125.9 1966.7 1659.3 878.86 1507.7 False True 1669.4084458481923 1410.3756653888868 1770.3249516050482 1815.8112991146697 1943.0720421943988 2104.5153761627603 1818.3502356007466 1615.289973833994 1491.361230605276 1701.227981241649 0.9812961368233356 0.8290338984193745 1.0406159380901838 1.0673532995791613 1.1421585252649318 1.2370566434175212 1.0688457135966076 0.9494847202401804 0.8766380796986416 1.0 10.732360773909916 -5.373599879330899 6.455143378989455 1.0587033509434227 0.9061933619948125 0.24283179167137026 0.09958418192808169 0.3228870196282907 16.106242123342835 0.02894688054699754 0.06101755485446716 4.230582033235979e-06 5.373599879330899 -0.15250998894861023 YYNSDVHR ddPTM_A459_Selumetinib_30min_R2 4 YYNSDVHR 8 0 K7EL89;P19623 K7EL89 SRM Spermidine synthase 0 ;;; 209.19 0.00048524 9653100.0 74462.3 73385.7 93397.0 101085.0 105979.0 83338.8 77117.3 78657.3 74017.0 91339.0 False True 70323.9834622044 79014.1472177829 87387.93870296468 87317.04861864886 92664.97055571913 94817.96322569672 80703.40725503094 78886.17972058304 88822.4682077751 88701.8057427775 0.7928134368102251 0.8907839762238051 0.9851878208249463 0.98438862532129 1.0446796407328418 1.0689518937264388 0.9098282338136298 0.8893413055123323 1.0013603157679507 1.0 16.436675853970186 -4.942058041038549 2.1144835916716365 0.9845162582544302 0.7721836932199881 0.5904281915298994 0.05108869542978279 0.37908397531802673 2.4994814696966583 0.015484042444862525 0.13711471363288977 1.1427256056719196e-05 4.942058041038549 -0.2123325650344421 YYS(ph)DSDDELTVEQR ddPTM_A459_Selumetinib_30min_R2 1 YYSDSDDELTVEQR 14 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 YYS(0.996)DS(0.003)DDELTVEQR 175.6 6.8355e-05 5972200.0 25236.0 24710.0 25650.0 20919.0 25394.0 16773.0 22731.0 22594.0 15382.0 19669.0 True False 23833.484147712195 26605.1775448271 23999.706925608407 18069.796112712193 22203.778694759607 19083.32849986576 23788.03654062201 22659.744799361953 18458.829808989747 19101.104863800672 1.2477542172379807 1.3928606609164123 1.2564564770853275 0.9460079006716016 1.1624342598547242 0.9990693541519369 1.2453748990040752 1.186305449916953 0.9663749788616611 1.0 14.221368469926961 -5.57642963304151 7.793105865261919 1.088283843675853 1.321524831198057 0.5182963326137355 0.10060171144540947 0.17880800395687194 22.486090947262728 0.0267846189354924 0.046686779165158766 2.651980747793724e-06 5.57642963304151 0.2332409875222039 YYS(ph)IDDNQNK ddPTM_A459_Selumetinib_30min_R2 3 YYSIDDNQNK 10 0 Q8NI08-2;Q8NI08;Q8NI08-4;Q8NI08-3;Q5TF97;Q5TF96 Q8NI08-2 NCOA7 Nuclear receptor coactivator 7 1 YYS(1)IDDNQNK;YYS(1)IDDNQNK;YYS(1)IDDNQNK 171.62 0.00016919 41884700.0 246033.0 242850.0 269970.0 277814.0 270735.0 166424.0 258784.0 256345.0 237478.0 204088.0 True False 232359.47080813404 261475.81411417492 252600.42412111172 239975.2539441189 236722.8488983911 189347.39535334505 270817.96877076785 257090.92150980074 284980.2356897194 198195.44915569405 1.1723754092133678 1.319282633521875 1.2745016356186836 1.2108010298238703 1.19439094039153 0.955356927517552 1.3664187039835844 1.2971585503350325 1.437874769091448 1.0 17.59656431104856 -12.438576011417402 13.847479889332257 0.5732682051001692 1.2306220059435151 0.0 0.1447975454957138 0.0 0.0 0.0 0.03293280727347991 3.6427048886371745e-13 12.438576011417402 0.6573538008433459 YYSDS(ph)DDELTVEQR ddPTM_A459_Selumetinib_30min_R2 1 YYSDSDDELTVEQR 14 0 Q8NFC6 Q8NFC6 BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1 1 YYS(0.34)DS(0.66)DDELTVEQR 247.11 2.7061e-27 6146400.0 14964.0 13170.0 12409.0 12928.0 12998.0 8298.9 9350.3 10373.0 9605.4 11509.0 True False 14132.360785638191 14180.096651775511 11610.618449897653 11167.184097956086 11365.075036405671 9441.9981450865 9785.107477267957 10403.183712657408 11526.748397300094 11176.705266026844 1.2644478358569118 1.2687188499886362 1.038822996003102 0.9991481239019786 1.016853783462592 0.8447926218280777 0.8754912332716831 0.9307916300056098 1.0313189909675131 1.0 13.448207344394469 -5.374023349095129 1.3959195233705575 0.9395181386119758 1.3100132981291035 0.8083463868065447 0.05905784061122422 0.22804153386118325 0.7517048603570855 0.01936017000634931 0.08691190822549309 4.22645890826081e-06 5.374023349095129 0.37049515951712775 YYTS(ph)ASGDEMVSLK ddPTM_A459_Selumetinib_30min_R1 1 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 YYT(0.243)S(0.684)AS(0.073)GDEMVSLK 135.81 0.00089129 0.0 749.53 737.88 1074.8 832.83 1406.6 1013.7 928.06 1244.8 488.95 1078.5 True False 766.9925906685024 651.4886665688948 928.848063453799 687.3918746553046 1279.3732783553999 1003.5030983659585 858.0556870146075 1211.7838603197467 829.7124385049385 1216.9359804796172 0.6302653573988471 0.5353516347771482 0.7632678122375202 0.5648545902836981 1.0513069700274413 0.8246145355735633 0.7050951740915999 0.9957663178322331 0.6818045088764105 1.0 10.249037558651322 -6.241361089720396 24.9933680416254 0.8650619391064234 0.6271312461543617 0.4859332931409792 0.1271348388142961 739.4296194156751 920438.8960654169 0.03604694642246449 0.04647778076933267 5.736393173126718e-07 6.241361089720396 -0.2379306929520617 YYTSASGDEMVS(ph)LK ddPTM_A459_Selumetinib_30min_R2 1 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 YYTSASGDEMVS(1)LK 92.38 0.02415 0.0 9227.1 8172.2 9878.7 7490.7 10667.0 7268.1 5888.9 8386.9 6113.6 8949.7 True False 8714.294721007891 8798.981462235379 9243.115197115309 6470.453737821755 9326.916095810067 8269.214801757244 6162.745518633975 8411.304490473965 7336.490828256386 8691.29890688683 1.0026458432010479 1.0123896964656482 1.0634906584321049 0.7444748831149602 1.0731325887802092 0.9514360155309888 0.709070713670971 0.967784514212139 0.8441190329379975 1.0 13.085356087304628 -7.020396595818408 24.738868186535225 0.8708010003840666 0.9766662541141962 0.14677691849660002 0.11210484536441587 1242.189415847813 1506638.1743575751 0.04131066847008616 0.03241583386691985 9.541208890508177e-08 7.020396595818408 0.10586525373012956 YYTSASGDEMVS(ph)LKDYCTR ddPTM_A459_Selumetinib_30min_R1 1 YYTSASGDEMVSLKDYCTR 19 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 YYTSASGDEMVS(1)LKDYCTR 130.52 0.00015723 18633000.0 1506.9 1734.4 1739.6 1948.8 1427.0 1443.8 1224.5 1490.6 1080.1 1265.2 True False 1542.0078380830207 1531.335641699315 1503.3718749388054 1608.4786635066687 1297.928101957312 1429.2766828655135 1132.134979149395 1451.0644458488234 1832.8508126172067 1427.6007440916196 1.0801394188570546 1.072663801862685 1.0530758555294806 1.1267006340278574 0.9091674316709479 1.001173954819532 0.793033335009762 1.0164357589853554 1.283867930303894 1.0 10.4793768431209 -6.246607563475637 24.649387454179596 0.9910839085553987 1.0802484804845793 0.10429119969326306 0.11637634932922518 1608.4180685360038 2673070.5615987326 0.035798378631438206 0.04601247119368832 5.667511845744324e-07 6.246607563475637 0.08916457192918059 YYVTIIDAPGHR ddPTM_A459_Selumetinib_30min_R1 2 YYVTIIDAPGHR 12 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 ; 153.54 0.00065527 160875000.0 11721.0 15844.7 11545.4 13375.0 10535.5 10988.599999999999 11054.0 8796.1 6606.6 8774.9 False True 11994.076494904164 13989.595157998807 9977.59809434266 11039.307329844865 9582.565885193593 10878.064660850516 10220.187880373544 8562.798854240464 11210.917673027358 9901.24388976411 1.2113706750829178 1.4129128939507518 1.0077115769926126 1.1149414611690642 0.9678143465489255 1.0986563690342224 1.0322125173524064 0.8648205164497232 1.132273661556523 1.0 13.273394066507345 -5.271732547227251 24.98718122310784 1.026204867397223 1.3121417851548425 0.6331667684204033 0.08671954254316046 353.27887296156587 857603.1291965977 0.021568651366084778 0.04571380653641108 5.348936630334631e-06 5.271732547227251 0.2859369177576194 YYVTIIDAPGHR ddPTM_A459_Selumetinib_30min_R2 2 YYVTIIDAPGHR 12 0 P68104;A0A087WVQ9;Q5VTE0;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 ; 127.17 0.0036958 46796000.0 226891.0 254241.0 242129.0 263586.0 294972.0 212657.0 177078.0 217093.0 179405.0 247015.0 False True 214281.30653663696 273740.46718633774 226550.68375012203 227685.13208878785 257914.98027686178 241948.57144195712 185312.4778734005 217724.7046883192 215291.012994526 239883.03512795447 0.893274117622943 1.1411414193601628 0.9444214495171744 0.9491506223745243 1.0751697390325623 1.0086105977144273 0.7725118109104887 0.9076286056335083 0.897483279214343 1.0 17.871971606214856 -7.202135236082254 24.9343553312585 0.8867082161359361 1.006599507680205 0.2834897423106857 0.08321429750511314 282.9460193898791 118964.17342981583 0.030462340464281482 0.02359602108304837 6.278628165429456e-08 7.202135236082254 0.11989129154426892